Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	G	C	tCw	wGa	tC	Ga	tC_mutation	tC_mutation_to_G	tC_mutation_to_T	APOBEC_mutation	APOBEC_mutation_to_G	APOBEC_mutation_to_T	[tCw_to_G+tCw_to_T]_per_mut	tCw_to_G+tCw_to_T	BH_Fisher_p-value_tCw	APOBEC_enrich	tCw_to_G_enrich	tCw_to_T_enrich	p-value_GvT_skew	BH_p-value_GvT_skew	APOBEC_MutLoad_MinEstimate	"CONTEXT(+/-20)"	g_counts	c_counts	tcw_counts	wga_counts	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample	x	x1	x2	x3	x4	x5	x6	newbase	end	tum_allele1	tum_allele2	start	effect_idx	newbase_idx	pat_idx	is_coding	is_flank	is_indel	is_ins	is_del	is_missense	is_nonsense	is_splice	is_silent	gene_idx	context_and_effect	context65	categ_idx	trackpos	categ	gene	chr	pos	type	classification	ref_allele	patient	DistBetween_Mutations	Distance_to_LT_end	Distance_to_RT_end	Strain_Mutation_ID	Dataset_Mutation_ID	Complex_ID	Complex_Size	StrainCluster_ID	Dataset_Cluster_ID	Distance_Between_Clusters	Cluster_Size_Mutations	Cluster_Size_Complexes	Cluster_Length	Cluster_Coordination	Content_of_non_coordinated_cluster	Cluster_Pvalue
KIAA0090	23065	broad.mit.edu	37	chr1	19549914	19549914	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	acccagttctctgaatgcacGatatggacagggcctttggc	11	11	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:19549914G>A	uc001bbo.2	-	19	2395	c.2352C>T	c.(2350-2352)ATC>ATT	p.I784I	KIAA0090_uc001bbn.2_5'Flank|KIAA0090_uc001bbp.2_Silent_p.I783I|KIAA0090_uc001bbq.2_Silent_p.I783I|KIAA0090_uc001bbr.2_Silent_p.I762I	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	784	DUF1620.|Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		CTGAATGCACGATATGGACAG	0.537													0	0	0	0.004482	0	8	281										A	19549914	G	A	19549914	2	1	1	1	0	0	0	0	0	0	0	1	8153	1048	37	1		1	KIAA0090	1	19549914	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		19549914	229700707	1	1										
ARID1A	8289	broad.mit.edu	37	chr1	27099309	27099309	+	Frame_Shift_Del	DEL	C	C	-													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcctcactctggagcaggagCaattcagttgggatccagga					rs138311127		TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:27099309delC	uc001bmv.1	+	14	3919	c.3546delC	c.(3544-3546)AGCfs	p.S1182fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.S1181fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.S1182fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.S799fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.S28fs|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1182					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGAGCAGGAGCAATTCAGTTG	0.478			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													29	43	---	---								-	27099309	C	-	27099309	7	5	1	1	0	1	0	1	0	0	0	0	913	709	25	0	3600	0	ARID1A	1	27099309	Frame_Shift_Del	DEL	C	TCGA-BL-A0C8-01A-11D-A10S-08	7549395	27099309	222151312	2	2										
COL9A2	1298	broad.mit.edu	37	chr1	40766912	40766912	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cagaggcataggccgaagctCcaaggcaggcggcaggttca	15	11	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:40766912C>G	uc001cfh.1	-	32	2082	c.2012G>C	c.(2011-2013)GGA>GCA	p.G671A	COL9A2_uc001cfi.1_Missense_Mutation_p.G490A	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	671	Nonhelical region 1 (NC1).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GGCCGAAGCTCCAAGGCAGGC	0.677													0	0	0	0.016522	0	22	34										G	40766912	C	G	40766912	3	3	1	1	0	0	0	0	1	0	0	0	3708	855	30	1	61	1	COL9A2	1	40766912	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	13667603	40766912	208483709	3	3										
SLC6A9	6536	broad.mit.edu	37	chr1	44474107	44474107	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gctgggcaaggcggctggccGagagccattggtgaggttgg	20	8	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:44474107G>A	uc001cll.2	-	5	919	c.727C>T	c.(727-729)CGG>TGG	p.R243W	SLC6A9_uc009vxe.2_Missense_Mutation_p.R99W|SLC6A9_uc010okm.1_Missense_Mutation_p.R170W|SLC6A9_uc001clm.2_Missense_Mutation_p.R189W|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.R174W|SLC6A9_uc001cln.2_Missense_Mutation_p.R170W|SLC6A9_uc010oko.1_Missense_Mutation_p.R59W|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	243	Extracellular (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GCGGCTGGCCGAGAGCCATTG	0.642													0	0	0	0.006122	0	15	111										A	44474107	G	A	44474107	3	1	1	1	0	0	0	0	1	0	0	0	14691	1057	37	1	1433	1	SLC6A9	1	44474107	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	3707195	44474107	204776514	4	4										
HSPB11	51668	broad.mit.edu	37	chr1	54395807	54395807	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttcctgtggtggtccaaaacGtttctggattcctattgtta	9	8	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:54395807G>A	uc001cwh.2	-	3	186	c.110C>T	c.(109-111)ACG>ATG	p.T37M	HSPB11_uc001cwi.1_Missense_Mutation_p.T37M	NM_016126	NP_057210	Q9Y547	HSB11_HUMAN	heat shock protein family B (small), member 11	37					cell adhesion|response to stress						0						GGTCCAAAACGTTTCTGGATT	0.284													0	0	0	0.01441	0	49	76										A	54395807	G	A	54395807	3	1	1	1	0	0	0	0	1	0	0	0	7419	1145	40	2	340	2	HSPB11	1	54395807	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	9921700	54395807	194854814	5	5										
ITGA10	8515	broad.mit.edu	37	chr1	145534100	145534100	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cagcagtccttgctgaccctCcaaggaacacttcagccaga	8	15	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:145534100C>G	uc001eoa.2	+	14	1681	c.1605C>G	c.(1603-1605)CTC>CTG	p.L535L	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.L404L|ITGA10_uc009wiw.2_Silent_p.L392L|ITGA10_uc010oyw.1_Silent_p.L480L	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	535	Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGCTGACCCTCCAAGGAACAC	0.532													0	0	0	0.011902	0	43	175										G	145534100	C	G	145534100	2	3	1	1	0	0	0	0	0	0	0	1	7873	842	30	1		1	ITGA10	1	145534100	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	91138293	145534100	103716521	6	6										
S100A8	6279	broad.mit.edu	37	chr1	153362976	153362976	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tacttgtggtagacgtcgatGatagagttcaaggctttctc	11	7	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:153362976G>A	uc001fbs.2	-	2	91	c.36C>T	c.(34-36)ATC>ATT	p.I12I		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	12	EF-hand 1.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGACGTCGATGATAGAGTTCA	0.493													0	0	0	0.01441	0	64	231										A	153362976	G	A	153362976	2	1	1	1	0	0	0	0	0	0	0	1	13786	1280	45	1		1	S100A8	1	153362976	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	7828876	153362976	95887645	7	7										
CCT3	7203	broad.mit.edu	37	chr1	156281973	156281973	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gttccaacatcatcttctctCagttcctctggtcggctgac	7	14	5	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:156281973C>G	uc001fol.1	-	11	1234	c.1014G>C	c.(1012-1014)CTG>CTC	p.L338L	CCT3_uc001fom.1_Silent_p.L337L|CCT3_uc001fon.1_Silent_p.L300L|CCT3_uc010phj.1_Silent_p.L292L|CCT3_uc010phk.1_Silent_p.L292L|CCT3_uc010phl.1_Silent_p.L292L	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	338					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CATCTTCTCTCAGTTCCTCTG	0.478													0	0	0	0.012213	0	31	78										G	156281973	C	G	156281973	2	3	1	1	0	0	0	0	0	0	0	1	2954	813	29	1		1	CCT3	1	156281973	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	2918997	156281973	92968648	8	8										
NES	10763	broad.mit.edu	37	chr1	156647053	156647053	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctcctcccccatgcagccctCcatcctgctcgtctgaccca	5	22	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:156647053C>G	uc001fpq.2	-	1	137	c.4G>C	c.(4-6)GAG>CAG	p.E2Q		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	2	Head.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATGCAGCCCTCCATCCTGCTC	0.627													0	0	0	0.009096	0	4	33										G	156647053	C	G	156647053	3	3	1	1	0	0	0	0	1	0	0	0	10337	864	30	1	4877	1	NES	1	156647053	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	365080	156647053	92603568	9	9										
PEAR1	375033	broad.mit.edu	37	chr1	156884482	156884483	+	Frame_Shift_Ins	INS	-	-	C													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cccctctgcctccgggcctaINSccccccggccactatgactc							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:156884482_156884483insC	uc001fqj.1	+	23	3122_3123	c.3006_3007insC	c.(3004-3009)CTACCCfs	p.L1002fs	PEAR1_uc001fqk.1_Frame_Shift_Ins_p.L627fs	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	1002_1003	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTCCGGGCCTACCCCCCGGCCA	0.609																		17	139	---	---								C	156884483	-	C	156884482	7	5	1	1	0	1	1	0	0	0	0	0	11712	378	14	0	3092	0	PEAR1	1	156884482	Frame_Shift_Ins	INS	-	TCGA-BL-A0C8-01A-11D-A10S-08	237429	156884482	92366139	10	10										
PVRL4	81607	broad.mit.edu	37	chr1	161047356	161047356	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	taggcaccaagtggaactctGaggtgacggcagcagagcgg	16	9	1	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:161047356G>A	uc001fxo.2	-	3	916	c.617C>T	c.(616-618)TCA>TTA	p.S206L	PVRL4_uc010pjy.1_5'Flank|PVRL4_uc010pjz.1_5'Flank	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	206	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GTGGAACTCTGAGGTGACGGC	0.622													0	0	0	0.01441	0	53	424										A	161047356	G	A	161047356	3	1	1	1	0	0	0	0	1	0	0	0	12842	1294	45	1	943	1	PVRL4	1	161047356	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	4162874	161047356	88203265	11	11										
FMO2	2327	broad.mit.edu	37	chr1	171154946	171154946	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gacttgagcccacttgctttGagagaactgaagatattgga	11	7	0	5			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:171154946G>C	uc001ghk.1	+	2	211	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	FMO2_uc010pmd.1_Intron	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	32					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CACTTGCTTTGAGAGAACTGA	0.463													0	0	0	0.013114	0	43	157										C	171154946	G	C	171154946	3	2	1	1	0	0	0	0	1	0	0	0	5955	1291	45	1	96	1	FMO2	1	171154946	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	10107590	171154946	78095675	12	12										
C1orf9	51430	broad.mit.edu	37	chr1	172558229	172558229	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agattatcttgtgttagctcAaccacccttactacttcctg	5	12	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:172558229A>T	uc001giq.3	+	18	2304	c.1988A>T	c.(1987-1989)CAA>CTA	p.Q663L	C1orf9_uc010pmm.1_Missense_Mutation_p.Q663L|C1orf9_uc009wwd.2_Missense_Mutation_p.Q619L|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	663					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		GTGTTAGCTCAACCACCCTTA	0.398													0	0	0	0.001168	0	5	45										T	172558229	A	T	172558229	3	4	1	1	0	0	0	0	1	0	0	0	2067	130	5	5	2058	5	C1orf9	1	172558229	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	1403283	172558229	76692392	13	13										
LAMC2	3918	broad.mit.edu	37	chr1	183209495	183209495	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gttacaatccaagacacactCaacacattagacggcctcct	5	14	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:183209495C>T	uc001gqa.2	+	22	3611	c.3297C>T	c.(3295-3297)CTC>CTT	p.L1099L	LAMC2_uc001gpz.3_Silent_p.L1099L|LAMC2_uc010poa.1_Silent_p.L799L	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1099	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						AAGACACACTCAACACATTAG	0.498													0	0	0	0.004482	0	9	53										T	183209495	C	T	183209495	2	4	1	1	0	0	0	0	0	0	0	1	8615	813	29	1		1	LAMC2	1	183209495	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	10651266	183209495	66041126	14	14										
NVL	4931	broad.mit.edu	37	chr1	224492852	224492852	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcatatcactctccaaaagaGaagaatcttttgaatcctgg	6	9	4	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:224492852G>C	uc001hok.2	-	7	675	c.632C>G	c.(631-633)TCT>TGT	p.S211C	NVL_uc001hol.2_Missense_Mutation_p.S105C|NVL_uc010pvd.1_Missense_Mutation_p.S120C|NVL_uc010pve.1_5'UTR|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	211						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		CTCCAAAAGAGAAGAATCTTT	0.318													0	0	0	0.007291	0	29	60										C	224492852	G	C	224492852	3	2	1	1	0	0	0	0	1	0	0	0	10780	942	33	1	2006	1	NVL	1	224492852	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	41283357	224492852	24757769	15	15										
SDCCAG8	10806	broad.mit.edu	37	chr1	243471361	243471361	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	taaagcataaagaatttcttCtggctgctaatacttgtaac	6	7	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:243471361C>G	uc001hzw.2	+	8	967	c.811C>G	c.(811-813)CTG>GTG	p.L271V	SDCCAG8_uc010pyk.1_Missense_Mutation_p.L126V|SDCCAG8_uc010pyl.1_Missense_Mutation_p.L83V|SDCCAG8_uc001hzx.2_Missense_Mutation_p.L83V	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	271	Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		AGAATTTCTTCTGGCTGCTAA	0.368													0	0	0	0.01441	0	90	91										G	243471361	C	G	243471361	3	3	1	1	0	0	0	0	1	0	0	0	13959	912	32	1	841	1	SDCCAG8	1	243471361	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	18978509	243471361	5779260	16	16										
OR2T6	254879	broad.mit.edu	37	chr1	248551039	248551039	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tggccatgatagctaatgggGtcatgatcttcctgattaac	10	8	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr1:248551039G>A	uc001iei.1	+	1	130	c.130G>A	c.(130-132)GTC>ATC	p.V44I		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGCTAATGGGGTCATGATCTT	0.468													0	0	0	0.008871	0	20	82										A	248551039	G	A	248551039	3	1	1	1	0	0	0	0	1	0	0	0	11029	1261	44	2	132	2	OR2T6	1	248551039	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	5079678	248551039	699582	17	17										
PXDN	7837	broad.mit.edu	37	chr2	1652125	1652125	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cgtgtgtgccatggagaacaGccgctccgtgagctccgtgt	14	12	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:1652125G>T	uc002qxa.2	-	17	3491	c.3427C>A	c.(3427-3429)CTG>ATG	p.L1143M		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1143					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ATGGAGAACAGCCGCTCCGTG	0.652													1	0	0.00909568	0.009096	0.00943256	3	31										T	1652125	G	T	1652125	3	4	1	1	0	0	0	0	1	0	0	0	12847	962	34	4	1040	4	PXDN	2	1652125	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		1652125	241547248	18	18										
C2orf44	80304	broad.mit.edu	37	chr2	24253912	24253912	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cacctggactgtgagaaaaaGagtctctgaagacatctgac	10	9	2	5			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:24253912G>C	uc002rep.2	-	4	2188	c.2057C>G	c.(2056-2058)TCT>TGT	p.S686C	C2orf44_uc010eya.2_3'UTR	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	686							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGAGAAAAAGAGTCTCTGAA	0.473													0	0	0	0.016723	0	14	64										C	24253912	G	C	24253912	3	2	1	1	0	0	0	0	1	0	0	0	2168	942	33	1	112	1	C2orf44	2	24253912	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	22601787	24253912	218945461	19	19										
USP34	9736	broad.mit.edu	37	chr2	61415533	61415533	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	acagtggaggtctttaaattCtttacaatcgtcatatctac	6	8	4	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:61415533C>G	uc002sbe.2	-	80	10367	c.10345G>C	c.(10345-10347)GAA>CAA	p.E3449Q	USP34_uc002sbd.2_Missense_Mutation_p.E251Q	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3449					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TCTTTAAATTCTTTACAATCG	0.418													0	0	0	0.007291	0	30	118										G	61415533	C	G	61415533	3	3	1	1	0	0	0	0	1	0	0	0	17062	922	32	1	299	1	USP34	2	61415533	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	37161621	61415533	181783840	20	20										
USP34	9736	broad.mit.edu	37	chr2	61607465	61607465	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gttacgagctgcactctgtcGtaactcctgatccgagagct	10	12	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:61607465G>A	uc002sbe.2	-	7	875	c.853C>T	c.(853-855)CGA>TGA	p.R285*		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	285					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GCACTCTGTCGTAACTCCTGA	0.368													0	0	0	0.006214	0	8	74										A	61607465	G	A	61607465	4	1	1	1	0	0	0	0	0	1	0	0	17062	1153	40	2	10083	2	USP34	2	61607465	Nonsense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	191932	61607465	181591908	21	21										
TANC1	85461	broad.mit.edu	37	chr2	160033027	160033027	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgactgtaagagcaaattttCaggtaacaaagaattctcaa	7	6	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:160033027C>A	uc002uag.2	+	13	2174	c.1900C>A	c.(1900-1902)CAG>AAG	p.Q634K	TANC1_uc010fol.1_Missense_Mutation_p.Q528K|TANC1_uc010zcm.1_Missense_Mutation_p.Q626K|TANC1_uc010fom.1_Missense_Mutation_p.Q440K|TANC1_uc002uai.1_RNA	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	634						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AGCAAATTTTCAGGTAACAAA	0.323													1	0	1.67942e-08	0.006122	1.84924e-08	16	55										A	160033027	C	A	160033027	3	1	1	1	0	0	0	0	1	0	0	0	15541	827	29	3	1942	3	TANC1	2	160033027	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	98425562	160033027	83166346	22	22										
FIGN	55137	broad.mit.edu	37	chr2	164467360	164467361	+	Frame_Shift_Ins	INS	-	-	A													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ccataactggagtccatatcINStccttgccctgccatgtaga							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:164467360_164467361insA	uc002uck.1	-	3	1292_1293	c.981_982insT	c.(979-984)GGAGATfs	p.G327fs		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	327_328						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						GAGTCCATATCTCCTTGCCCTG	0.465																		80	89	---	---								A	164467361	-	A	164467360	7	5	1	1	0	1	1	0	0	0	0	0	5891	913	32	0	1301	0	FIGN	2	164467360	Frame_Shift_Ins	INS	-	TCGA-BL-A0C8-01A-11D-A10S-08	4434333	164467360	78732013	23	23										
TTN	7273	broad.mit.edu	37	chr2	179616159	179616159	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctcattgtcttaaaatgtatAgttctcatcattcccttttg	4	9	4	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:179616159A>C	uc002unb.2	-	46	11192	c.10968T>G	c.(10966-10968)ACT>ACG	p.T3656T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAAATGTATAGTTCTCATCA	0.348													0	0	0	0.001168	0	6	121										C	179616159	A	C	179616159	2	2	1	1	0	0	0	0	0	0	0	1	16732	407	15	5		5	TTN	2	179616159	Silent	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	15148799	179616159	63583214	24	24										
ITGA4	3676	broad.mit.edu	37	chr2	182359492	182359492	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	caaatcgttaagtatgtttgGacagtctatatcaggacaaa	8	6	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:182359492G>A	uc002unu.2	+	12	2055	c.1292G>A	c.(1291-1293)GGA>GAA	p.G431E		NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	431	FG-GAP 7.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AGTATGTTTGGACAGTCTATA	0.308													0	0	0	0.00308	0	5	148										A	182359492	G	A	182359492	3	1	1	1	0	0	0	0	1	0	0	0	7878	1174	41	1	1338	1	ITGA4	2	182359492	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	2743333	182359492	60839881	25	25										
PMS1	5378	broad.mit.edu	37	chr2	190719590	190719590	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	accatgtaaagtaagtaataAtaattatccaatccctgaac	4	8	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:190719590A>G	uc002urh.3	+	9	2121	c.1592A>G	c.(1591-1593)AAT>AGT	p.N531S	PMS1_uc010zga.1_Missense_Mutation_p.N492S|PMS1_uc010zgb.1_Missense_Mutation_p.N470S|PMS1_uc002urk.3_Missense_Mutation_p.N492S|PMS1_uc002uri.3_Missense_Mutation_p.N531S|PMS1_uc010zgc.1_Missense_Mutation_p.N355S|PMS1_uc010zgd.1_Missense_Mutation_p.N355S|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.N492S|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.N316S|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Missense_Mutation_p.N199S	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	531					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GTAAGTAATAATAATTATCCA	0.284			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					0	0	0	0.013726	0	33	33										G	190719590	A	G	190719590	3	3	1	1	0	0	0	0	1	0	0	0	12142	101	4	5	1622	5	PMS1	2	190719590	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	8360098	190719590	52479783	26	26										
SF3B1	23451	broad.mit.edu	37	chr2	198265453	198265453	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cattacctctgtagtctgttCttggaaagcataaagaatac	7	8	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:198265453C>T	uc002uue.2	-	18	2752	c.2704G>A	c.(2704-2706)GAA>AAA	p.E902K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	902					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTAGTCTGTTCTTGGAAAGCA	0.318													0	0	0	0.01441	0	87	37										T	198265453	C	T	198265453	3	4	1	1	0	0	0	0	1	0	0	0	14149	922	32	1	1242	1	SF3B1	2	198265453	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	7545863	198265453	44933920	27	27										
SATB2	23314	broad.mit.edu	37	chr2	200137185	200137185	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtgtttggggagatccagctGagccgaaagagtgtggatgg	18	5	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:200137185G>A	uc002uuy.1	-	11	2768	c.1951C>T	c.(1951-1953)CAG>TAG	p.Q651*	SATB2_uc010fsq.1_Nonsense_Mutation_p.Q533*|SATB2_uc002uuz.1_Nonsense_Mutation_p.Q651*|SATB2_uc002uva.1_Nonsense_Mutation_p.Q651*	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	651	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGATCCAGCTGAGCCGAAAGA	0.542													0	0	0	0.007413	0	20	108										A	200137185	G	A	200137185	4	1	1	1	0	0	0	0	0	1	0	0	13854	1299	45	1	254	1	SATB2	2	200137185	Nonsense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	1871732	200137185	43062188	28	28										
VIL1	7429	broad.mit.edu	37	chr2	219290520	219290520	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gaggccttccgaggctacttCaagcaaggccttgtgtaggg	14	10	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:219290520C>T	uc002via.2	+	4	398	c.333C>T	c.(331-333)TTC>TTT	p.F111F	VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Silent_p.F111F|VIL1_uc002vic.1_Silent_p.F111F	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	111	Core.|Necessary for homodimerization.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGGCTACTTCAAGCAAGGCC	0.612													0	0	0	0.006999	0	39	30										T	219290520	C	T	219290520	2	4	1	1	0	0	0	0	0	0	0	1	17161	825	29	1		1	VIL1	2	219290520	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	19153335	219290520	23908853	29	29										
SLC23A3	151295	broad.mit.edu	37	chr2	220034109	220034109	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gataaggaactctaaggatgGagcctggacaagaggcagcc	14	8	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:220034109G>C	uc010zks.1	-	3	451	c.340C>G	c.(340-342)CCA>GCA	p.P114A	NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Missense_Mutation_p.P114A|SLC23A3_uc010fwb.2_Missense_Mutation_p.P114A|SLC23A3_uc002vjs.1_5'Flank|SLC23A3_uc002vjt.1_5'UTR	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	114	Cytoplasmic (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCTAAGGATGGAGCCTGGACA	0.597													0	0	0	0.01441	0	93	60										C	220034109	G	C	220034109	3	2	1	1	0	0	0	0	1	0	0	0	14464	1174	41	1	1556	1	SLC23A3	2	220034109	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	743589	220034109	23165264	30	30										
OBSL1	23363	broad.mit.edu	37	chr2	220422740	220422740	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gaccacgggggcgccagcccGggacagttcacagctcagca	14	15	2	0	rs143517287	by1000genomes	TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:220422740G>A	uc010fwk.2	-	11	3652	c.3595C>T	c.(3595-3597)CGG>TGG	p.R1199W	OBSL1_uc002vmh.1_Missense_Mutation_p.R190W|OBSL1_uc010zli.1_Missense_Mutation_p.R98W|OBSL1_uc010fwl.1_Missense_Mutation_p.R674W	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1199	Ig-like 10.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCGCCAGCCCGGGACAGTTCA	0.667													0	0	0	0.010729	0	11	15										A	220422740	G	A	220422740	3	1	1	1	0	0	0	0	1	0	0	0	10813	1115	39	2	2162	2	OBSL1	2	220422740	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	388631	220422740	22776633	31	31										
CAPN10	11132	broad.mit.edu	37	chr2	241536312	241536312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcactctgcatcagcactgcCggcccagtgacaccgagttc	9	16	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr2:241536312C>T	uc002vzk.1	+	9	1880	c.1696C>T	c.(1696-1698)CGG>TGG	p.R566W	CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.R438W|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_Intron|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	566	Domain III 2.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TCAGCACTGCCGGCCCAGTGA	0.647													0	0	0	0.00632	0	27	25										T	241536312	C	T	241536312	3	4	1	1	0	0	0	0	1	0	0	0	2623	643	23	2	1730	2	CAPN10	2	241536312	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	21113572	241536312	1663061	32	32										
CNTN6	27255	broad.mit.edu	37	chr3	1363500	1363500	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gaggaagaaaccttgcaaagGgtcaactcattttttatggt	10	6	2	1	rs149799168	byFrequency	TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:1363500G>T	uc003boz.2	+	8	1195	c.928G>T	c.(928-930)GGT>TGT	p.G310C	CNTN6_uc011asj.1_Missense_Mutation_p.G238C|CNTN6_uc003bpa.2_Missense_Mutation_p.G310C	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	310					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CCTTGCAAAGGGTCAACTCAT	0.358													1	0	1.22574e-08	0.014323	1.35731e-08	21	98										T	1363500	G	T	1363500	3	4	1	1	0	0	0	0	1	0	0	0	3645	1232	43	4	954	4	CNTN6	3	1363500	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		1363500	196658930	33	33										
EFHB	151651	broad.mit.edu	37	chr3	19938244	19938244	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtaattaactttcttcaggtGatgccgaactgctgcaatca	8	9	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:19938244G>A	uc003cbl.3	-	9	1856	c.1660C>T	c.(1660-1662)CAC>TAC	p.H554Y	EFHB_uc003cbm.2_Missense_Mutation_p.H424Y	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	554					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						TTCTTCAGGTGATGCCGAACT	0.458													0	0	0	0.013726	0	36	72										A	19938244	G	A	19938244	3	1	1	1	0	0	0	0	1	0	0	0	4945	1290	45	1	861	1	EFHB	3	19938244	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	18574744	19938244	178084186	34	34										
RAB5A	5868	broad.mit.edu	37	chr3	20019815	20019815	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	taaacaggaagcacagtcctAtgcagatgacaatagtttat	8	7	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:20019815A>C	uc003cbn.2	+	5	987	c.452A>C	c.(451-453)TAT>TCT	p.Y151S	RAB5A_uc010hey.2_RNA|RAB5A_uc011awg.1_Missense_Mutation_p.Y137S	NM_004162	NP_004153	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	151					blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0						GCACAGTCCTATGCAGATGAC	0.308													0	0	0	0.01441	0	58	102										C	20019815	A	C	20019815	3	2	1	1	0	0	0	0	1	0	0	0	12948	449	16	5	466	5	RAB5A	3	20019815	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	81571	20019815	178002615	35	35										
CCR3	1232	broad.mit.edu	37	chr3	46306948	46306948	+	Frame_Shift_Del	DEL	T	T	-													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgtcagggggcataactgggTttttggccatggcatgtgta							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:46306948delT	uc003cpg.1	+	4	842	c.299delT	c.(298-300)GTTfs	p.V100fs	CCR3_uc003cpi.1_Frame_Shift_Del_p.V100fs|CCR3_uc003cpj.1_Frame_Shift_Del_p.V100fs|CCR3_uc003cpk.1_Frame_Shift_Del_p.V121fs|CCR3_uc010hjb.1_Frame_Shift_Del_p.V118fs|CCR3_uc003cpl.1_Frame_Shift_Del_p.V133fs	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	100	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CATAACTGGGTTTTTGGCCAT	0.488																		9	2458	---	---								-	46306948	T	-	46306948	7	5	1	1	0	1	0	1	0	0	0	0	2942	1725	60	0	368	0	CCR3	3	46306948	Frame_Shift_Del	DEL	T	TCGA-BL-A0C8-01A-11D-A10S-08	26287133	46306948	151715482	36	36										
QARS	5859	broad.mit.edu	37	chr3	49135633	49135633	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcatgaacctaccaggttcaGgtcacttaaaaatccaccag	6	12	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:49135633G>A	uc003cvx.2	-	22	2148	c.2143C>T	c.(2143-2145)CTG>TTG	p.L715L	QARS_uc011bcc.1_Silent_p.L168L|QARS_uc011bcd.1_Silent_p.L570L|QARS_uc003cvy.2_Silent_p.L570L|QARS_uc011bce.1_Silent_p.L704L	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	715					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	ACCAGGTTCAGGTCACTTAAA	0.552													0	0	0	0.004007	0	15	130										A	49135633	G	A	49135633	2	1	1	1	0	0	0	0	0	0	0	1	12871	991	35	2		2	QARS	3	49135633	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	2828685	49135633	148886797	37	37										
MST1	4485	broad.mit.edu	37	chr3	49721756	49721756	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctgccaccaacctcacaggcCcccacaggggccaacagtcc	8	20	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:49721756C>T	uc003cxg.2	-	17	2079	c.2007G>A	c.(2005-2007)GGG>GGA	p.G669G		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	655	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCTCACAGGCCCCCACAGGGG	0.567													0	0	0	0.01441	0	56	62										T	49721756	C	T	49721756	2	4	1	1	0	0	0	0	0	0	0	1	9890	610	22	2		2	MST1	3	49721756	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	586123	49721756	148300674	38	38										
RNF123	63891	broad.mit.edu	37	chr3	49736242	49736242	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttgacctggatgatggcactCtgtccttctgcctgtgagtt	11	10	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:49736242C>G	uc003cxh.2	+	9	711	c.625C>G	c.(625-627)CTG>GTG	p.L209V	RNF123_uc010hky.1_5'Flank|RNF123_uc003cxi.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	209	B30.2/SPRY.					cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TGATGGCACTCTGTCCTTCTG	0.632													0	0	0	0.012213	0	34	44										G	49736242	C	G	49736242	3	3	1	1	0	0	0	0	1	0	0	0	13433	912	32	1	655	1	RNF123	3	49736242	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	14486	49736242	148286188	39	39										
AMIGO3	386724	broad.mit.edu	37	chr3	49756064	49756064	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttccggccgctctaggccaaGagctggggccgacgagcagt	15	13	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:49756064G>C	uc003cxj.2	-	1	1175	c.835C>G	c.(835-837)CTT>GTT	p.L279V	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	279	Extracellular (Potential).|Ig-like C2-type.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTAGGCCAAGAGCTGGGGCC	0.647													0	0	0	0.005443	0	26	34										C	49756064	G	C	49756064	3	2	1	1	0	0	0	0	1	0	0	0	577	942	33	1	683	1	AMIGO3	3	49756064	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	19822	49756064	148266366	40	40										
GNAT1	2779	broad.mit.edu	37	chr3	50231195	50231195	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtctcgcgcagctacctctcCgacctggagcgcctggtaac	11	16	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:50231195C>T	uc003cym.2	+	5	575	c.459C>T	c.(457-459)TCC>TCT	p.S153S	GNAT1_uc003cyl.2_Silent_p.S153S	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	153					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		GCTACCTCTCCGACCTGGAGC	0.512													0	0	0	0.001984	0	7	16										T	50231195	C	T	50231195	2	4	1	1	0	0	0	0	0	0	0	1	6511	639	23	2		2	GNAT1	3	50231195	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	475131	50231195	147791235	41	41										
CACNA2D2	9254	broad.mit.edu	37	chr3	50402325	50402325	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ccccctctcctcactgtcgcGttgtagtcgaagcagatgtg	10	14	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:50402325G>T	uc003daq.2	-	38	3344	c.3306C>A	c.(3304-3306)AAC>AAA	p.N1102K	CACNA2D2_uc003dap.2_Missense_Mutation_p.N1095K|CACNA2D2_uc003dao.2_Missense_Mutation_p.N175K	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	1102	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TCACTGTCGCGTTGTAGTCGA	0.592													1	0	1.28384e-07	0.012319	1.39023e-07	19	25										T	50402325	G	T	50402325	3	4	1	1	0	0	0	0	1	0	0	0	2549	1136	40	4	154	4	CACNA2D2	3	50402325	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	171130	50402325	147620105	42	42										
SLMAP	7871	broad.mit.edu	37	chr3	57893702	57893702	+	Frame_Shift_Del	DEL	A	A	-													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gaagcccaggagctagctagAacaagtaaacaaaaatgctt							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:57893702delA	uc003dje.1	+	16	1747	c.1542delA	c.(1540-1542)AGAfs	p.R514fs	SLMAP_uc003djd.1_Frame_Shift_Del_p.R497fs|SLMAP_uc003djf.1_Frame_Shift_Del_p.R476fs|SLMAP_uc003djg.1_Frame_Shift_Del_p.R108fs|SLMAP_uc011bez.1_Intron|SLMAP_uc011bfa.1_Frame_Shift_Del_p.R48fs|SLMAP_uc003djh.2_Intron|SLMAP_uc003dji.1_Frame_Shift_Del_p.R48fs|SLMAP_uc011bfb.1_Frame_Shift_Del_p.R48fs|SLMAP_uc011bfc.1_Intron	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	514	Cytoplasmic (Potential).|Potential.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		AGCTAGCTAGAACAAGTAAAC	0.343																		9	72	---	---								-	57893702	A	-	57893702	7	5	1	1	0	1	0	1	0	0	0	0	14749	243	9	0	1549	0	SLMAP	3	57893702	Frame_Shift_Del	DEL	A	TCGA-BL-A0C8-01A-11D-A10S-08	7491377	57893702	140128728	43	43										
PDZRN3	23024	broad.mit.edu	37	chr3	73433413	73433414	+	Frame_Shift_Ins	INS	-	-	G													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gggagatctccagggtgagcINSggggtgctgcggcagctctc							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:73433413_73433414insG	uc003dpl.1	-	10	2399_2400	c.2303_2304insC	c.(2302-2304)CCGfs	p.P768fs	PDZRN3_uc011bgh.1_Frame_Shift_Ins_p.P425fs|PDZRN3_uc010hoe.1_Frame_Shift_Ins_p.P466fs|PDZRN3_uc011bgf.1_Frame_Shift_Ins_p.P485fs|PDZRN3_uc011bgg.1_Frame_Shift_Ins_p.P488fs	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	768							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CCAGGGTGAGCGGGGTGCTGCG	0.649																		12	52	---	---								G	73433414	-	G	73433413	7	5	1	1	0	1	1	0	0	0	0	0	11709	755	27	0	900	0	PDZRN3	3	73433413	Frame_Shift_Ins	INS	-	TCGA-BL-A0C8-01A-11D-A10S-08	15539711	73433413	124589017	44	44										
GOLGB1	2804	broad.mit.edu	37	chr3	121409850	121409851	+	Frame_Shift_Ins	INS	-	-	TC													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cggtttcagaaagaagagcaINStctctctctctgtttaagag							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:121409850_121409851insTC	uc003eei.3	-	14	8471_8472	c.8345_8346insGA	c.(8344-8346)GATfs	p.D2782fs	GOLGB1_uc010hrc.2_Frame_Shift_Ins_p.D2787fs|GOLGB1_uc003eej.3_Frame_Shift_Ins_p.D2748fs	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2782	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AAAGAAGAGCATCTCTCTCTCT	0.426																		33	125	---	---								TC	121409851	-	TC	121409850	7	5	1	1	0	1	1	0	0	0	0	0	6565	214	8	0	1469	0	GOLGB1	3	121409850	Frame_Shift_Ins	INS	-	TCGA-BL-A0C8-01A-11D-A10S-08	47976437	121409850	76612580	45	45										
PLSCR4	57088	broad.mit.edu	37	chr3	145917695	145917695	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gcccatacaatcagtgacccGgaggacgaagggccttagtg	13	11	1	1	rs34036393		TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:145917695G>A	uc010huy.2	-	6	858	c.529C>T	c.(529-531)CGG>TGG	p.R177W	PLSCR4_uc010huz.2_Missense_Mutation_p.R177W|PLSCR4_uc003evt.3_Missense_Mutation_p.R177W|PLSCR4_uc010hva.2_Intron|PLSCR4_uc003evu.3_Intron	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	177	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						TCAGTGACCCGGAGGACGAAG	0.483													0	0	0	0.001168	0	6	71										A	145917695	G	A	145917695	3	1	1	1	0	0	0	0	1	0	0	0	12112	1115	39	2	476	2	PLSCR4	3	145917695	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	24507845	145917695	52104735	46	46										
ECE2	9718	broad.mit.edu	37	chr3	184009213	184009213	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ccaaccaccagctcttcttcGtgggatttgcccaggtatca	8	14	3	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:184009213G>A	uc003fni.3	+	18	2499	c.2461G>A	c.(2461-2463)GTG>ATG	p.V821M	ECE2_uc011brh.1_3'UTR|ECE2_uc003fnl.3_Missense_Mutation_p.V749M|ECE2_uc003fnm.3_Missense_Mutation_p.V703M|ECE2_uc003fnk.3_Missense_Mutation_p.V674M|ECE2_uc011bri.1_Missense_Mutation_p.V736M	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	821	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCTCTTCTTCGTGGGATTTGC	0.587													0	0	0	0.01892	0	21	85										A	184009213	G	A	184009213	3	1	1	1	0	0	0	0	1	0	0	0	4890	1145	40	2	3095	2	ECE2	3	184009213	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	38091518	184009213	14013217	47	47										
MUC4	4585	broad.mit.edu	37	chr3	195477929	195477929	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cgagggcggtactggaactcCgagatgaccatccagtgttg	14	10	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr3:195477929C>T	uc011bto.1	-	24	15778	c.15318G>A	c.(15316-15318)TCG>TCA	p.S5106S	MUC4_uc010hzq.2_Silent_p.S91S|MUC4_uc003fuz.2_Silent_p.S832S|MUC4_uc003fva.2_Silent_p.S714S|MUC4_uc003fvb.2_Silent_p.S750S|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Silent_p.S750S|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Silent_p.S714S|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Silent_p.S798S|MUC4_uc011bti.1_Silent_p.S798S|MUC4_uc011btj.1_Silent_p.S975S|MUC4_uc011btk.1_Silent_p.S714S|MUC4_uc011btl.1_Silent_p.S743S|MUC4_uc011btm.1_Silent_p.S923S|MUC4_uc011btn.1_Silent_p.S714S|MUC4_uc003fvo.2_Silent_p.S998S|MUC4_uc003fvp.2_Silent_p.S947S	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1991					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACTGGAACTCCGAGATGACCA	0.652													0	0	0	0.010729	0	11	91										T	195477929	C	T	195477929	2	4	1	1	0	0	0	0	0	0	0	1	9978	639	23	2		2	MUC4	3	195477929	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	11468716	195477929	2544501	48	48										
POLN	353497	broad.mit.edu	37	chr4	2130948	2130948	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tttggatgaaacaaacatggCcctcggggagatcgtgagaa	13	7	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:2130948C>A	uc003ger.2	-	16	1825	c.1825G>T	c.(1825-1827)GCC>TCC	p.A609S	POLN_uc010icg.1_Missense_Mutation_p.A57S|POLN_uc010ich.1_Missense_Mutation_p.A141S	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	609					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			ACAAACATGGCCCTCGGGGAG	0.403								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					1	0	2.24893e-16	0.009718	2.5188e-16	37	61										A	2130948	C	A	2130948	3	1	1	1	0	0	0	0	1	0	0	0	12207	739	26	4	913	4	POLN	4	2130948	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		2130948	189023328	49	49										
HGFAC	3083	broad.mit.edu	37	chr4	3451002	3451002	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctggcctgcgagaagaacggCgtggcttacctctacggcat	13	12	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:3451002C>T	uc003ghc.2	+	14	1827	c.1824C>T	c.(1822-1824)GGC>GGT	p.G608G	HGFAC_uc010icw.2_Silent_p.G615G	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	608	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		AGAAGAACGGCGTGGCTTACC	0.677													0	0	0	0.015359	0	32	70										T	3451002	C	T	3451002	2	4	1	1	0	0	0	0	0	0	0	1	7086	755	27	2		2	HGFAC	4	3451002	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	1320054	3451002	187703274	50	50										
CNGA1	1259	broad.mit.edu	37	chr4	47939675	47939675	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ggaagaactcaaacatacgaGagaaccgtaacaacctgttt	8	9	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:47939675G>A	uc003gxt.3	-	11	1102	c.836C>T	c.(835-837)TCT>TTT	p.S279F	uc003gxr.1_Intron|CNGA1_uc003gxu.2_Missense_Mutation_p.S348F	NM_000087	NP_000078	P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1 isoform	279	Extracellular (Potential).				response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			ovary(2)	2						AAACATACGAGAGAACCGTAA	0.358													0	0	0	0.015359	0	37	78										A	47939675	G	A	47939675	3	1	1	1	0	0	0	0	1	0	0	0	3596	942	33	1	1240	1	CNGA1	4	47939675	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	44488673	47939675	143214601	51	51										
EPHA5	2044	broad.mit.edu	37	chr4	66201800	66201800	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agagagcagcaggacaatccAtggggcttggcagacgatag	15	8	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:66201800A>T	uc003hcy.2	-	16	2895	c.2702T>A	c.(2701-2703)ATG>AAG	p.M901K	EPHA5_uc003hcx.2_Missense_Mutation_p.M833K|EPHA5_uc003hcz.2_Missense_Mutation_p.M879K|EPHA5_uc011cah.1_Missense_Mutation_p.M902K|EPHA5_uc011cai.1_Missense_Mutation_p.M880K|EPHA5_uc003hda.2_Missense_Mutation_p.M902K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	901	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AGGACAATCCATGGGGCTTGG	0.448										TSP Lung(17;0.13)			0	0	0	0.009096	0	4	66										T	66201800	A	T	66201800	3	4	1	1	0	0	0	0	1	0	0	0	5170	217	8	5	423	5	EPHA5	4	66201800	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	18262125	66201800	124952476	52	52										
USO1	8615	broad.mit.edu	37	chr4	76692248	76692248	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gttctaggtgtttcaagattGatggacttactagcggattc	11	6	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:76692248G>C	uc003hiu.2	+	6	688	c.513G>C	c.(511-513)TTG>TTC	p.L171F	USO1_uc003hiv.2_Missense_Mutation_p.L6F|USO1_uc003hiw.2_Missense_Mutation_p.L6F	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	171	Globular head.|ARM 3.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTTCAAGATTGATGGACTTAC	0.308													0	0	0	0.013537	0	11	34										C	76692248	G	C	76692248	3	2	1	1	0	0	0	0	1	0	0	0	17036	1281	45	1	380	1	USO1	4	76692248	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	10490448	76692248	114462028	53	53										
BMP2K	55589	broad.mit.edu	37	chr4	79763561	79763561	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ggacaggtagtgaatcaaatGaataagaagctacagacggg	13	5	1	4			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:79763561G>T	uc003hlk.2	+	4	592	c.426G>T	c.(424-426)ATG>ATT	p.M142I	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.M142I	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	142	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						TGAATCAAATGAATAAGAAGC	0.343													1	0	0.000157383	0.00308	0.000167647	7	45										T	79763561	G	T	79763561	3	4	1	1	0	0	0	0	1	0	0	0	1460	1290	45	3	440	3	BMP2K	4	79763561	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	3071313	79763561	111390715	54	54										
ANK2	287	broad.mit.edu	37	chr4	114251495	114251495	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	attattccacctcggaaatgTactgctccaacgcgagtcac	7	13	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:114251495T>C	uc003ibe.3	+	27	3094	c.2994T>C	c.(2992-2994)TGT>TGC	p.C998C	ANK2_uc003ibd.3_Silent_p.C989C|ANK2_uc003ibf.3_Silent_p.C998C|ANK2_uc011cgc.1_Silent_p.C207C|ANK2_uc003ibg.3_Silent_p.C26C|ANK2_uc003ibc.2_Silent_p.C974C|ANK2_uc011cgb.1_Silent_p.C1013C	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	998	ZU5.|Interaction with SPTBN1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTCGGAAATGTACTGCTCCAA	0.537													0	0	0	0.014758	0	5	60										C	114251495	T	C	114251495	2	2	1	1	0	0	0	0	0	0	0	1	621	1644	57	5		5	ANK2	4	114251495	Silent	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	34487934	114251495	76902781	55	55										
DCHS2	54798	broad.mit.edu	37	chr4	155160322	155160322	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgcaattataaataactcacCattcttaggatcaatggaga	6	7	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:155160322C>T	uc003inw.2	-	24	6127	c.6127G>A	c.(6127-6129)GGC>AGC	p.G2043S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2043	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AATAACTCACCATTCTTAGGA	0.368													0	0	0	0.004482	0	6	45										T	155160322	C	T	155160322	3	4	1	1	0	0	0	0	1	0	0	0	4288	608	21	2	2631	2	DCHS2	4	155160322	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	40908827	155160322	35993954	56	56										
GUCY1A3	2982	broad.mit.edu	37	chr4	156634276	156634276	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gacctcaaaggccaaatgatCtacattgttgaatccagtgc	8	10	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:156634276C>G	uc003iov.2	+	8	1649	c.1113C>G	c.(1111-1113)ATC>ATG	p.I371M	GUCY1A3_uc010iqc.2_Missense_Mutation_p.I371M|GUCY1A3_uc003iow.2_Missense_Mutation_p.I371M|GUCY1A3_uc010iqd.2_Missense_Mutation_p.I370M|GUCY1A3_uc003iox.2_Missense_Mutation_p.I371M|GUCY1A3_uc003ioz.2_Missense_Mutation_p.I136M|GUCY1A3_uc003ioy.2_Missense_Mutation_p.I371M|GUCY1A3_uc010iqe.2_Missense_Mutation_p.I136M|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.I371M	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	371					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GCCAAATGATCTACATTGTTG	0.423													0	0	0	0.00632	0	28	68										G	156634276	C	G	156634276	3	3	1	1	0	0	0	0	1	0	0	0	6894	903	32	1	1146	1	GUCY1A3	4	156634276	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	1473954	156634276	34520000	57	57										
MARCH1	55016	broad.mit.edu	37	chr4	164534483	164534483	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tacctgcagatgtcctgagtGgatggacagacagacaacct	11	10	0	4			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:164534483G>T	uc003iqs.1	-	5	1202	c.225C>A	c.(223-225)TCC>TCA	p.S75S	MARCH1_uc003iqr.1_Silent_p.S58S	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	75	RING-CH-type.				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGTCCTGAGTGGATGGACAGA	0.418													1	0	4.47668e-21	0.021523	5.07184e-21	24	91										T	164534483	G	T	164534483	2	4	1	1	0	0	0	0	0	0	0	1	9298	1335	47	4		4	MARCH1	4	164534483	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	7900207	164534483	26619793	58	58										
FBXO8	26269	broad.mit.edu	37	chr4	175158643	175158643	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	actaatattttgagcagcgcGacgggtatttcgaataaatt	9	6	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:175158643G>A	uc003itp.2	-	6	1730	c.880C>T	c.(880-882)CGC>TGC	p.R294C	FBXO8_uc003itq.2_Missense_Mutation_p.R253C	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	294					regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		TGAGCAGCGCGACGGGTATTT	0.383													0	0	0	0.006122	0	19	54										A	175158643	G	A	175158643	3	1	1	1	0	0	0	0	1	0	0	0	5761	1058	37	1	83	1	FBXO8	4	175158643	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	10624160	175158643	15995633	59	59										
HELT	391723	broad.mit.edu	37	chr4	185941788	185941788	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctgcccagcgcgccagtgccGctcgctagcccagcgcagca	12	19	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr4:185941788G>A	uc011ckq.1	+	4	846	c.846G>A	c.(844-846)CCG>CCA	p.P282P	HELT_uc011cko.1_Silent_p.P197P|HELT_uc003ixa.3_Silent_p.P196P|HELT_uc011ckp.1_Silent_p.P140P	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	282	Pro-rich.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		CGCCAGTGCCGCTCGCTAGCC	0.741													0	0	0	0.009096	0	4	32										A	185941788	G	A	185941788	2	1	1	1	0	0	0	0	0	0	0	1	7048	1074	38	2		2	HELT	4	185941788	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	10783145	185941788	5212488	60	60										
DNAH5	1767	broad.mit.edu	37	chr5	13865842	13865842	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	acctctgaccaaagaatatcAtaatagctatttacagtttc	4	9	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:13865842A>G	uc003jfd.2	-	27	4332	c.4290T>C	c.(4288-4290)TAT>TAC	p.Y1430Y		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1430	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAAGAATATCATAATAGCTAT	0.313									Kartagener_syndrome				0	0	0	0.020292	0	15	114										G	13865842	A	G	13865842	2	3	1	1	0	0	0	0	0	0	0	1	4604	224	8	5		5	DNAH5	5	13865842	Silent	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08		13865842	167049418	61	61										
MAST4	375449	broad.mit.edu	37	chr5	66462291	66462291	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cccggtccccagaagccaccGacggaggcagacaagcccaa	11	17	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:66462291G>A	uc003jut.1	+	28	6785	c.6717G>A	c.(6715-6717)CCG>CCA	p.P2239P	MAST4_uc003juw.2_Silent_p.P2167P|MAST4_uc003jux.2_5'UTR	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	2431						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGAAGCCACCGACGGAGGCAG	0.652											OREG0016638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014758	0	3	4										A	66462291	G	A	66462291	2	1	1	1	0	0	0	0	0	0	0	1	9327	1045	37	1		1	MAST4	5	66462291	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	52596449	66462291	114452969	62	62										
SNCAIP	9627	broad.mit.edu	37	chr5	121786336	121786336	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	caagaggggattcaggttctTggaagcctgtcagcctccag	13	10	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:121786336T>A	uc003ksw.1	+	10	2000	c.1794T>A	c.(1792-1794)CTT>CTA	p.L598L	SNCAIP_uc011cwl.1_Silent_p.L156L|SNCAIP_uc003ksx.1_Silent_p.L645L|SNCAIP_uc003ksy.1_Silent_p.L232L|SNCAIP_uc003ksz.1_Silent_p.L232L|SNCAIP_uc010jcu.2_Silent_p.L194L|SNCAIP_uc011cwm.1_Silent_p.L232L|SNCAIP_uc003kta.1_Silent_p.L230L|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.L292L|SNCAIP_uc010jcx.1_Silent_p.L538L|uc003ktb.1_RNA|SNCAIP_uc003ktc.1_Silent_p.L114L	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	598					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TTCAGGTTCTTGGAAGCCTGT	0.478													0	0	0	0.014758	0	5	144										A	121786336	T	A	121786336	2	1	1	1	0	0	0	0	0	0	0	1	14841	1799	63	5		5	SNCAIP	5	121786336	Silent	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	55324045	121786336	59128924	63	63										
PDLIM4	8572	broad.mit.edu	37	chr5	131607548	131607548	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gccagcaagctgggcgctccGctgagcggcctgcaggggct	17	14	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:131607548G>A	uc003kwn.2	+	6	812	c.735G>A	c.(733-735)CCG>CCA	p.P245P	uc003kwm.3_Intron|PDLIM4_uc003kwp.2_Intron|PDLIM4_uc003kwo.2_Silent_p.P353P	NM_003687	NP_003678	P50479	PDLI4_HUMAN	PDZ and LIM domain 4 isoform 1	245							protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGGGCGCTCCGCTGAGCGGCC	0.726													0	0	0	0.00308	0	8	21										A	131607548	G	A	131607548	2	1	1	1	0	0	0	0	0	0	0	1	11682	1074	38	2		2	PDLIM4	5	131607548	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	9821212	131607548	49307712	64	64										
SEC24A	10802	broad.mit.edu	37	chr5	134041037	134041037	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gcgaaagaagaattcgtgttCatactttgtgtttgccagta	10	6	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:134041037C>A	uc003kzs.2	+	17	2749	c.2461C>A	c.(2461-2463)CAT>AAT	p.H821N	SEC24A_uc011cxu.1_Missense_Mutation_p.H585N	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	821					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATTCGTGTTCATACTTTGTG	0.373													1	0	4.17463e-26	0.01441	4.78495e-26	56	112										A	134041037	C	A	134041037	3	1	1	1	0	0	0	0	1	0	0	0	13994	826	29	3	2527	3	SEC24A	5	134041037	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	2433489	134041037	46874223	65	65										
SEC24A	10802	broad.mit.edu	37	chr5	134041067	134041067	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtttgccagtagtttcgactCtgaatgatgtctttcttgga	10	7	3	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:134041067C>T	uc003kzs.2	+	17	2779	c.2491C>T	c.(2491-2493)CTG>TTG	p.L831L	SEC24A_uc011cxu.1_Silent_p.L595L	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	831					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGTTTCGACTCTGAATGATGT	0.358													0	0	0	0.01441	0	61	128										T	134041067	C	T	134041067	2	4	1	1	0	0	0	0	0	0	0	1	13994	912	32	1		1	SEC24A	5	134041067	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	30	134041067	46874193	66	66										
PCDHB1	29930	broad.mit.edu	37	chr5	140432966	140432966	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atatctgagagagaccccatGatgcagaaattgatcattct	8	8	3	5			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:140432966G>T	uc003lik.1	+	1	1988	c.1911G>T	c.(1909-1911)ATG>ATT	p.M637I		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	637	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGACCCCATGATGCAGAAAT	0.433													1	0	2.17888e-05	0.006214	2.33366e-05	8	274										T	140432966	G	T	140432966	3	4	1	1	0	0	0	0	1	0	0	0	11534	1290	45	3	1913	3	PCDHB1	5	140432966	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	6391899	140432966	40482294	67	67										
PCDHGA1	56114	broad.mit.edu	37	chr5	140712541	140712541	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tctccctcactgcggactcgCggaagagccacctgattttc	9	15	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:140712541C>T	uc003lji.1	+	1	2290	c.2290C>T	c.(2290-2292)CGG>TGG	p.R764W	PCDHGA1_uc011dan.1_Missense_Mutation_p.R764W	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	764	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGGACTCGCGGAAGAGCCA	0.582													0	0	0	0.004482	0	7	222										T	140712541	C	T	140712541	3	4	1	1	0	0	0	0	1	0	0	0	11550	759	27	2	2292	2	PCDHGA1	5	140712541	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	279575	140712541	40202719	68	68										
PCDHGB2	56103	broad.mit.edu	37	chr5	140741617	140741617	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgggcgacagggacgcggccCgccagcgcctgctggtcgct	17	15	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:140741617C>T	uc003ljs.1	+	1	1915	c.1915C>T	c.(1915-1917)CGC>TGC	p.R639C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.R639C|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	639	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCGGCCCGCCAGCGCCT	0.682													0	0	0	0.010729	0	11	20										T	140741617	C	T	140741617	3	4	1	1	0	0	0	0	1	0	0	0	11563	652	23	2	1917	2	PCDHGB2	5	140741617	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	29076	140741617	40173643	69	69										
GPR151	134391	broad.mit.edu	37	chr5	145895383	145895383	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcccaaacacttttggagtaCgccgtagctcggataggtgc	11	11	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:145895383C>T	uc003lod.1	-	1	294	c.294G>A	c.(292-294)GCG>GCA	p.A98A		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	98	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTTTGGAGTACGCCGTAGCTC	0.512													0	0	0	0.009535	0	31	99										T	145895383	C	T	145895383	2	4	1	1	0	0	0	0	0	0	0	1	6657	523	19	2		2	GPR151	5	145895383	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	5153766	145895383	35019877	70	70										
ODZ2	57451	broad.mit.edu	37	chr5	167689593	167689593	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtcctggaccaggcgagacaGagggccctgggcacggcctg	17	13	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr5:167689593G>C	uc010jjd.2	+	29	8076	c.8076G>C	c.(8074-8076)CAG>CAC	p.Q2692H	ODZ2_uc003lzr.3_Missense_Mutation_p.Q2462H|ODZ2_uc003lzt.3_Missense_Mutation_p.Q2065H|ODZ2_uc010jje.2_Missense_Mutation_p.Q1956H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		AGGCGAGACAGAGGGCCCTGG	0.657													0	0	0	0.004672	0	3	6										C	167689593	G	C	167689593	3	2	1	1	0	0	0	0	1	0	0	0	10835	933	33	1	8190	1	ODZ2	5	167689593	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	21794210	167689593	13225667	71	71										
RIPK1	8737	broad.mit.edu	37	chr6	3104493	3104493	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cgaaaatgcagttgtgaagaGaatgcagtctcttcaacttg	10	7	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:3104493G>C	uc010jni.2	+	8	1182	c.950G>C	c.(949-951)AGA>ACA	p.R317T	RIPK1_uc003muv.3_Missense_Mutation_p.R154T|RIPK1_uc003muw.3_Missense_Mutation_p.R252T|RIPK1_uc011dhs.1_Missense_Mutation_p.R271T|RIPK1_uc003mux.2_Missense_Mutation_p.R317T	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	317	Interaction with SQSTM1.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				GTTGTGAAGAGAATGCAGTCT	0.338													0	0	0	0.01441	0	56	51										C	3104493	G	C	3104493	3	2	1	1	0	0	0	0	1	0	0	0	13380	942	33	1	976	1	RIPK1	6	3104493	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		3104493	168010574	72	72										
FAM50B	26240	broad.mit.edu	37	chr6	3850910	3850910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tggagaaggacgagtcgcacGcgggcaaggtggtgctgcgc	19	9	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:3850910G>A	uc003mvu.2	+	2	977	c.865G>A	c.(865-867)GCG>ACG	p.A289T		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	289						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				CGAGTCGCACGCGGGCAAGGT	0.642													0	0	0	0.01892	0	23	56										A	3850910	G	A	3850910	3	1	1	1	0	0	0	0	1	0	0	0	5578	1087	38	2	867	2	FAM50B	6	3850910	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	746417	3850910	167264157	73	73										
NUP153	9972	broad.mit.edu	37	chr6	17675597	17675597	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agtgttctttgaaacagttaTatctgaaacaaaattacata	5	5	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:17675597T>C	uc003ncd.1	-	4	786	c.586A>G	c.(586-588)ATA>GTA	p.I196V	NUP153_uc011dje.1_Missense_Mutation_p.I196V|NUP153_uc010jpl.1_Missense_Mutation_p.I196V	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	196					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GAAACAGTTATATCTGAAACA	0.353													0	0	0	0.004007	0	16	52										C	17675597	T	C	17675597	3	2	1	1	0	0	0	0	1	0	0	0	10755	1406	49	5	3917	5	NUP153	6	17675597	Missense_Mutation	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	13824687	17675597	153439470	74	74										
HIST1H3F	8968	broad.mit.edu	37	chr6	26250692	26250692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gcggcggatttcacggagggCgacagtaccaggcctgtagc	16	11	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:26250692C>T	uc003nhg.1	-	1	144	c.142G>A	c.(142-144)GCC>ACC	p.A48T	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	48					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						TCACGGAGGGCGACAGTACCA	0.607													0	0	0	0.004656	0	21	134										T	26250692	C	T	26250692	3	4	1	1	0	0	0	0	1	0	0	0	7160	768	27	2	272	2	HIST1H3F	6	26250692	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	8575095	26250692	144864375	75	75										
TRIM26	7726	broad.mit.edu	37	chr6	30154266	30154266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcttgtacaggctggtgtagGtcacgcacttccagtcctct	10	12	3	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:30154266G>A	uc003npr.2	-	9	1216	c.1007C>T	c.(1006-1008)ACC>ATC	p.T336I	TRIM26_uc003nps.2_Missense_Mutation_p.T336I|TRIM26_uc010jry.2_Missense_Mutation_p.T66I|TRIM26_uc003npt.2_Missense_Mutation_p.T336I	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	336	B30.2/SPRY.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						GCTGGTGTAGGTCACGCACTT	0.577													0	0	0	0.009096	0	4	87										A	30154266	G	A	30154266	3	1	1	1	0	0	0	0	1	0	0	0	16497	1261	44	2	616	2	TRIM26	6	30154266	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	3903574	30154266	140960801	76	76										
NOTCH4	4855	broad.mit.edu	37	chr6	32169171	32169171	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cccccactctgggtccccatCttcaggcctgcagtcacctc	7	20	4	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:32169171C>T	uc003obb.2	-	22	4001	c.3862G>A	c.(3862-3864)GAT>AAT	p.D1288N	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1288	LNR 3.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGGTCCCCATCTTCAGGCCTG	0.627													0	0	0	0.007413	0	20	45										T	32169171	C	T	32169171	3	4	1	1	0	0	0	0	1	0	0	0	10551	913	32	1	2185	1	NOTCH4	6	32169171	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	2014905	32169171	138945896	77	77										
TRERF1	55809	broad.mit.edu	37	chr6	42236137	42236137	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtcctcacgctgctggtgctGggacaggtggctctgctggt	16	11	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:42236137G>A	uc003osd.2	-	5	1755	c.1192C>T	c.(1192-1194)CAG>TAG	p.Q398*	TRERF1_uc011duq.1_Nonsense_Mutation_p.Q398*|TRERF1_uc003osb.2_Nonsense_Mutation_p.Q237*|TRERF1_uc003osc.2_Nonsense_Mutation_p.Q237*|TRERF1_uc003ose.2_Nonsense_Mutation_p.Q398*	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	398	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGCTGGTGCTGGGACAGGTGG	0.627													0	0	0	0.01441	0	106	103										A	42236137	G	A	42236137	4	1	1	1	0	0	0	0	0	1	0	0	16472	1357	47	2	2466	2	TRERF1	6	42236137	Nonsense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	10066966	42236137	128878930	78	78										
XPO5	57510	broad.mit.edu	37	chr6	43538336	43538336	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atgtttgctggatgtcccttCttctttgagggggaagtgtc	13	7	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:43538336C>A	uc003ovp.2	-	5	735	c.524G>T	c.(523-525)AGA>ATA	p.R175I		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	175					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GATGTCCCTTCTTCTTTGAGG	0.403													1	0	2.69673e-31	0.01441	3.10918e-31	73	355										A	43538336	C	A	43538336	3	1	1	1	0	0	0	0	1	0	0	0	17444	913	32	3	3202	3	XPO5	6	43538336	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	1302199	43538336	127576731	79	79										
MCM9	254394	broad.mit.edu	37	chr6	119232920	119232920	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gccaggatccccaaccaataAaagatgagattctcctagga	8	11	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:119232920A>G	uc003pyh.2	-	7	1308	c.1045T>C	c.(1045-1047)TTA>CTA	p.L349L		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	349	MCM.				DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		CCAACCAATAAAAGATGAGAT	0.368													0	0	0	0.013726	0	31	50										G	119232920	A	G	119232920	2	3	1	1	0	0	0	0	0	0	0	1	9394	11	1	5		5	MCM9	6	119232920	Silent	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	75694584	119232920	51882147	80	80										
PTPRK	5796	broad.mit.edu	37	chr6	128411080	128411080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ccaaggattcccagtccacaGcaatccgtcttgcctgtatt	7	14	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:128411080G>A	uc003qbk.2	-	8	1587	c.1220C>T	c.(1219-1221)GCT>GTT	p.A407V	PTPRK_uc003qbj.2_Missense_Mutation_p.A407V|PTPRK_uc010kfc.2_Missense_Mutation_p.A407V|PTPRK_uc011ebu.1_Missense_Mutation_p.A407V|PTPRK_uc003qbl.1_Missense_Mutation_p.A277V|PTPRK_uc011ebv.1_Missense_Mutation_p.A407V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	407	Extracellular (Potential).|Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CCAGTCCACAGCAATCCGTCT	0.418													0	0	0	0.006214	0	9	78										A	128411080	G	A	128411080	3	1	1	1	0	0	0	0	1	0	0	0	12805	971	34	2	3216	2	PTPRK	6	128411080	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	9178160	128411080	42703987	81	81										
GRM1	2911	broad.mit.edu	37	chr6	146350852	146350852	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agaaagtgcccgagaggaagTgtggggagatcagggagcag	19	5	1	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr6:146350852T>A	uc010khw.1	+	2	669	c.199T>A	c.(199-201)TGT>AGT	p.C67S	GRM1_uc010khu.1_Missense_Mutation_p.C67S|GRM1_uc010khv.1_Missense_Mutation_p.C67S|GRM1_uc003qll.2_Missense_Mutation_p.C67S|GRM1_uc011edz.1_Missense_Mutation_p.C67S|GRM1_uc011eea.1_Missense_Mutation_p.C67S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	67	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGAGAGGAAGTGTGGGGAGAT	0.592													0	0	0	0.009096	0	3	74										A	146350852	T	A	146350852	3	1	1	1	0	0	0	0	1	0	0	0	6796	1696	59	5	201	5	GRM1	6	146350852	Missense_Mutation	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	17939772	146350852	24764215	82	82										
C7orf27	221927	broad.mit.edu	37	chr7	2586960	2586960	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gggaggccccaggctcacctGaagatactggaagcagtttt	13	10	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr7:2586960G>A	uc003smi.2	-	3	322	c.280C>T	c.(280-282)CAG>TAG	p.Q94*	C7orf27_uc003smj.1_Nonsense_Mutation_p.Q94*	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	94					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		AGGCTCACCTGAAGATACTGG	0.602													0	0	0	0.010818	0	31	66										A	2586960	G	A	2586960	4	1	1	1	0	0	0	0	0	1	0	0	2382	1299	45	1	2233	1	C7orf27	7	2586960	Nonsense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		2586960	156551703	83	83										
RADIL	55698	broad.mit.edu	37	chr7	4845343	4845343	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cagcccgcagggctgtccagCtcatctgggtgacaagaagg	14	12	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr7:4845343C>G	uc003snj.1	-	10	2317	c.2144G>C	c.(2143-2145)AGC>ACC	p.S715T	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Missense_Mutation_p.S220T|RADIL_uc011jwc.1_Missense_Mutation_p.S475T|RADIL_uc011jwd.1_RNA|RADIL_uc003snh.1_5'Flank	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	715	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGCTGTCCAGCTCATCTGGGT	0.662													0	0	0	0.010504	0	21	47										G	4845343	C	G	4845343	3	3	1	1	0	0	0	0	1	0	0	0	12997	797	28	4	1107	4	RADIL	7	4845343	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	2258383	4845343	154293320	84	84										
AUTS2	26053	broad.mit.edu	37	chr7	69583197	69583197	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	caagggcttccaccggagcaGctctcgggaaaggctcagtg	14	12	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr7:69583197G>T	uc003tvw.3	+	3	1345	c.602G>T	c.(601-603)AGC>ATC	p.S201I	AUTS2_uc003tvv.3_Missense_Mutation_p.S201I|AUTS2_uc003tvx.3_Missense_Mutation_p.S201I	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	201										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CACCGGAGCAGCTCTCGGGAA	0.438													1	0	0.000274275	0.004482	0.000290583	9	93										T	69583197	G	T	69583197	3	4	1	1	0	0	0	0	1	0	0	0	1225	971	34	4	612	4	AUTS2	7	69583197	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	64737854	69583197	89555466	85	85										
COL1A2	1278	broad.mit.edu	37	chr7	94047865	94047865	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctggcagagatggtgctcgtGtgagtagaattttgtttgta	14	4	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr7:94047865G>A	uc003ung.1	+	33	2496	c.2025_splice	c.e33+1	p.R675_splice	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Splice_Site	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor						axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TGGTGCTCGTGTGAGTAGAAT	0.348										HNSCC(75;0.22)			0	0	0	0.010771	0	40	75										A	94047865	G	A	94047865	5	1	1	1	0	0	0	0	0	0	1	0	3678	1391	48	2	2156	2	COL1A2	7	94047865	Splice_Site	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	24464668	94047865	65090798	86	86										
C7orf58	79974	broad.mit.edu	37	chr7	120740100	120740100	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttgcgtgcattcattcattcGacgggcacagtttggaatcc	10	10	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr7:120740100G>T	uc003vjq.3	+	7	1317	c.870G>T	c.(868-870)TCG>TCT	p.S290S	C7orf58_uc003vjr.1_Silent_p.S290S|C7orf58_uc003vjs.3_Silent_p.S290S|C7orf58_uc003vjt.3_Silent_p.S70S|C7orf58_uc010lkk.1_Silent_p.S70S	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	290						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TCATTCATTCGACGGGCACAG	0.423													1	0	9.78485e-24	0.013726	1.11502e-23	31	52										T	120740100	G	T	120740100	2	4	1	1	0	0	0	0	0	0	0	1	2405	1045	37	3		3	C7orf58	7	120740100	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	26692235	120740100	38398563	87	87										
PLXNA4	91584	broad.mit.edu	37	chr7	131910975	131910975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ggtgctggcgaaggtcatgcCggtctcctttgatttgagct	14	9	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr7:131910975C>T	uc003vra.3	-	8	2156	c.1927G>A	c.(1927-1929)GGC>AGC	p.G643S		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	643	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AAGGTCATGCCGGTCTCCTTT	0.557													0	0	0	0.01441	0	90	149										T	131910975	C	T	131910975	3	4	1	1	0	0	0	0	1	0	0	0	12122	652	23	2	3857	2	PLXNA4	7	131910975	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	11170875	131910975	27227688	88	88										
ESRP1	54845	broad.mit.edu	37	chr8	95674784	95674784	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	aagtttgaaagtggaacttgGtaagtgcttgagtactattt	11	3	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr8:95674784G>A	uc003ygq.3	+	6	827	c.644_splice	c.e6+1	p.C215_splice	ESRP1_uc003ygr.3_Splice_Site_p.C215_splice|ESRP1_uc003ygs.3_Splice_Site_p.C215_splice|ESRP1_uc003ygt.3_Splice_Site_p.C215_splice|ESRP1_uc003ygu.3_Splice_Site_p.C215_splice|ESRP1_uc003ygv.2_Splice_Site_p.C55_splice|ESRP1_uc003ygw.2_Splice_Site_p.C55_splice	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1						mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						GTGGAACTTGGTAAGTGCTTG	0.229													0	0	0	0.004007	0	14	25										A	95674784	G	A	95674784	5	1	1	1	0	0	0	0	0	0	1	0	5258	1275	44	2	667	2	ESRP1	8	95674784	Splice_Site	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		95674784	50689238	89	89										
VPS13B	157680	broad.mit.edu	37	chr8	100847965	100847973	+	Splice_Site	DEL	AGGTCAGTG	AGGTCAGTG	-													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	catcaacagtcagggaacacAggtcagtgagccatgtgttc							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr8:100847965_100847973delAGGTCAGTG	uc003yiv.2	+	54	10128	c.10017_splice	c.e54+1	p.Q3339_splice	VPS13B_uc003yiw.2_Splice_Site_p.Q3314_splice	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAGGGAACACAGGTCAGTGAGCCATGTGT	0.402																		26	112	---	---								-	100847973	AGGTCAGTG	-	100847965	8	5	1	1	0	1	0	1	0	0	1	0	17187	202	7	0	10420	0	VPS13B	8	100847965	Splice_Site	DEL	AGGTCAGTG	TCGA-BL-A0C8-01A-11D-A10S-08	5173181	100847965	45516057	90	90										
TOPORS	10210	broad.mit.edu	37	chr9	32544237	32544237	+	Missense_Mutation	SNP	C	C	T													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cttagaatcaggagatgcatCagctggtactgtctgttgca							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:32544237C>T	uc003zrb.2	-	3	453	c.286G>A	c.(286-288)GAT>AAT	p.D96N	TOPORS_uc003zrc.2_Missense_Mutation_p.D29N	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	96	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		GGAGATGCATCAGCTGGTACT	0.388													0	0	0	0.001984	0	7	91										T	32544237	C	T	32544237	3	4	1	1	0	0	0	0	1	0	0	0	16367	826	29	1	2855	1	TOPORS	9	32544237	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		32544237	108669194	91	91	1	2								
TOPORS	10210	broad.mit.edu	37	chr9	32544239	32544239	+	Missense_Mutation	SNP	G	G	A													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tagaatcaggagatgcatcaGctggtactgtctgttgcaat							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:32544239G>A	uc003zrb.2	-	3	451	c.284C>T	c.(283-285)GCT>GTT	p.A95V	TOPORS_uc003zrc.2_Missense_Mutation_p.A28V	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	95	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		AGATGCATCAGCTGGTACTGT	0.388													0	0	0	0.001984	0	7	90										A	32544239	G	A	32544239	3	1	1	1	0	0	0	0	1	0	0	0	16367	971	34	2	2857	2	TOPORS	9	32544239	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	2	32544239	108669192	92	92	1	2								
IPPK	64768	broad.mit.edu	37	chr9	95397569	95397569	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gacagcccttcggtaaccccGagcgctctggggtgtttttt	12	12	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:95397569G>A	uc004asl.1	-	10	1215	c.938C>T	c.(937-939)TCG>TTG	p.S313L	IPPK_uc004ask.1_Missense_Mutation_p.S12L	NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	313					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						CGGTAACCCCGAGCGCTCTGG	0.552											OREG0019315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	10	70										A	95397569	G	A	95397569	3	1	1	1	0	0	0	0	1	0	0	0	7801	1059	37	1	553	1	IPPK	9	95397569	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	62853330	95397569	45815862	93	93										
GABBR2	9568	broad.mit.edu	37	chr9	101258739	101258739	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gggatcgttggagaagctctCggtgtctgaaatctcaatgt	13	7	3	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:101258739C>T	uc004ays.2	-	4	844	c.688G>A	c.(688-690)GAG>AAG	p.E230K		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	230	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GAGAAGCTCTCGGTGTCTGAA	0.542													0	0	0	0.008291	0	9	73										T	101258739	C	T	101258739	3	4	1	1	0	0	0	0	1	0	0	0	6156	893	31	1	2201	1	GABBR2	9	101258739	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	5861170	101258739	39954692	94	94										
IKBKAP	8518	broad.mit.edu	37	chr9	111679867	111679867	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agggaagtgtaaagtgtccaTgaaggagtccatttttctca	11	6	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:111679867T>C	uc004bdm.3	-	9	1344	c.824A>G	c.(823-825)CAT>CGT	p.H275R	IKBKAP_uc004bdl.2_5'UTR|IKBKAP_uc011lwc.1_Missense_Mutation_p.H161R|IKBKAP_uc010mtq.2_5'UTR	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	275					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						AAAGTGTCCATGAAGGAGTCC	0.413													0	0	0	0.007413	0	20	132										C	111679867	T	C	111679867	3	2	1	1	0	0	0	0	1	0	0	0	7610	1464	51	5	3290	5	IKBKAP	9	111679867	Missense_Mutation	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	10421128	111679867	29533564	95	95										
ZNF883	169834	broad.mit.edu	37	chr9	115759604	115759604	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttctctcctgtatgcgtcctCtgatgtcgaattagtgatgt	9	9	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:115759604C>G	uc011lwy.1	-	5	2175	c.936G>C	c.(934-936)CAG>CAC	p.Q312H		NM_001101338	NP_001094808	P0CG24	ZN883_HUMAN	hypothetical protein LOC169834	312	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TATGCGTCCTCTGATGTCGAA	0.378													0	0	0	0.01441	0	81	135										G	115759604	C	G	115759604	3	3	1	1	0	0	0	0	1	0	0	0	18195	912	32	1	205	1	ZNF883	9	115759604	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	4079737	115759604	25453827	96	96										
COL27A1	85301	broad.mit.edu	37	chr9	116931561	116931561	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gcgatctgacaaccaggcctAgccccagacagccccagccc	9	19	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:116931561A>G	uc011lxl.1	+	3	1726	c.1726A>G	c.(1726-1728)AGC>GGC	p.S576G	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.S426G	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	576	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						AACCAGGCCTAGCCCCAGACA	0.667													0	0	0	0.003163	0	14	137										G	116931561	A	G	116931561	3	3	1	1	0	0	0	0	1	0	0	0	3685	420	15	5	1736	5	COL27A1	9	116931561	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	1171957	116931561	24281870	97	97										
TNC	3371	broad.mit.edu	37	chr9	117849019	117849019	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgtgaagccttcttcgcagtAgcaggtgccattgatgcagc	12	10	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:117849019A>C	uc004bjj.3	-	3	1353	c.991T>G	c.(991-993)TAC>GAC	p.Y331D	TNC_uc010mvf.2_Missense_Mutation_p.Y331D	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	331	EGF-like 6.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCTTCGCAGTAGCAGGTGCCA	0.602													0	0	0	0.007413	0	19	119										C	117849019	A	C	117849019	3	2	1	1	0	0	0	0	1	0	0	0	16267	420	15	5	5718	5	TNC	9	117849019	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	917458	117849019	23364412	98	98										
DBC1	1620	broad.mit.edu	37	chr9	121930487	121930487	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agtgactggacccttgcaagCcactgctgaattgtcctggg	12	11	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:121930487C>A	uc004bkc.2	-	8	1617	c.1161G>T	c.(1159-1161)TGG>TGT	p.W387C		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	387					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CCCTTGCAAGCCACTGCTGAA	0.517													1	0	0.00198382	0.001984	0.00206824	6	22										A	121930487	C	A	121930487	3	1	1	1	0	0	0	0	1	0	0	0	4247	740	26	4	1128	4	DBC1	9	121930487	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	4081468	121930487	19282944	99	99										
CIZ1	25792	broad.mit.edu	37	chr9	130928556	130928556	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cttgctgggtgttttgtcctGggtgttgggctgggagggtg	20	5	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:130928556G>A	uc004btt.2	-	17	2780	c.2617C>T	c.(2617-2619)CAG>TAG	p.Q873*	CIZ1_uc004btr.2_Nonsense_Mutation_p.Q845*|CIZ1_uc004bts.2_Nonsense_Mutation_p.Q844*|CIZ1_uc011maq.1_Nonsense_Mutation_p.Q812*|CIZ1_uc004btu.2_Nonsense_Mutation_p.Q793*|CIZ1_uc011mar.1_Nonsense_Mutation_p.Q772*|CIZ1_uc011mas.1_Nonsense_Mutation_p.Q929*|CIZ1_uc004btw.2_Nonsense_Mutation_p.Q817*|CIZ1_uc004btv.2_Nonsense_Mutation_p.Q873*	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	873						nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						GTTTTGTCCTGGGTGTTGGGC	0.662													0	0	0	0.001984	0	5	9										A	130928556	G	A	130928556	4	1	1	1	0	0	0	0	0	1	0	0	3441	1357	47	2	83	2	CIZ1	9	130928556	Nonsense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	8998069	130928556	10284875	100	100										
CRAT	1384	broad.mit.edu	37	chr9	131860642	131860642	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcacggtgatatccaggtccTggatcatgctgggggtgtgg	16	8	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:131860642T>C	uc004bxh.2	-	10	1496	c.1214A>G	c.(1213-1215)CAG>CGG	p.Q405R	CRAT_uc004bxg.2_Missense_Mutation_p.Q384R|CRAT_uc004bxk.3_Missense_Mutation_p.Q384R	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	405					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	ATCCAGGTCCTGGATCATGCT	0.587													0	0	0	0.01441	0	45	156										C	131860642	T	C	131860642	3	2	1	1	0	0	0	0	1	0	0	0	3847	1580	55	5	686	5	CRAT	9	131860642	Missense_Mutation	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	932086	131860642	9352789	101	101										
MED22	6837	broad.mit.edu	37	chr9	136211045	136211045	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atctcgtctcgcagcgtgatGagcttccggtcgcactcctc	10	15	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:136211045G>C	uc004cdc.2	-	4	582	c.348C>G	c.(346-348)CTC>CTG	p.L116L	MED22_uc004cdd.2_Silent_p.L116L	NM_133640	NP_598395	Q15528	MED22_HUMAN	mediator complex subunit 22 isoform b	116	Potential.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|mediator complex|soluble fraction	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.14e-06)|Epithelial(140;8.2e-06)|all cancers(34;6.94e-05)		GCAGCGTGATGAGCTTCCGGT	0.577													0	0	0	0.013114	0	46	75										C	136211045	G	C	136211045	2	2	1	1	0	0	0	0	0	0	0	1	9440	1277	45	1		1	MED22	9	136211045	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	4350403	136211045	5002386	102	102										
KIAA1984	84960	broad.mit.edu	37	chr9	139702037	139702037	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cccgcagacaccttccagttCcccgacatggaccacagcta	7	18	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:139702037C>T	uc004cjf.2	+	14	1548	c.1500C>T	c.(1498-1500)TTC>TTT	p.F500F	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|C9orf86_uc004cji.1_5'Flank|C9orf86_uc010nbr.1_5'Flank|LOC100131193_uc004cjg.1_Intron	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	500										ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)		CCTTCCAGTTCCCCGACATGG	0.617													0	0	0	0.001168	0	6	8										T	139702037	C	T	139702037	2	4	1	1	0	0	0	0	0	0	0	1	8266	854	30	1		1	KIAA1984	9	139702037	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	3490992	139702037	1511394	103	103										
NDOR1	27158	broad.mit.edu	37	chr9	140109624	140109624	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctcatccccgttatccggccGagggccttctccatcgcctc	8	19	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:140109624G>A	uc004clw.2	+	9	1254	c.1143G>A	c.(1141-1143)CCG>CCA	p.P381P	NDOR1_uc004clx.2_Silent_p.P381P|NDOR1_uc011mes.1_Silent_p.P381P|NDOR1_uc004cly.2_Silent_p.P347P	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	381	FAD-binding FR-type.|FAD (By similarity).				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TTATCCGGCCGAGGGCCTTCT	0.647													0	0	0	0.016522	0	23	25										A	140109624	G	A	140109624	2	1	1	1	0	0	0	0	0	0	0	1	10249	1045	37	1		1	NDOR1	9	140109624	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	407587	140109624	1103807	104	104										
EHMT1	79813	broad.mit.edu	37	chr9	140707963	140707963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtcccccatgaacatcgacaGaaatatcactcatctgcagg	7	13	3	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr9:140707963G>A	uc011mfc.1	+	21	3198	c.3161G>A	c.(3160-3162)AGA>AAA	p.R1054K	EHMT1_uc004coe.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1054					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		AACATCGACAGAAATATCACT	0.572													0	0	0	0.007413	0	17	33										A	140707963	G	A	140707963	3	1	1	1	0	0	0	0	1	0	0	0	4983	942	33	1	3292	1	EHMT1	9	140707963	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	598339	140707963	505468	105	105										
ADAMTS14	140766	broad.mit.edu	37	chr10	72520559	72520559	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	acaaagggcaacctggagaaGacctgagacatcccggcacc	11	13	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr10:72520559G>C	uc001jrh.2	+	22	3622	c.3622G>C	c.(3622-3624)GAC>CAC	p.D1208H	ADAMTS14_uc001jrg.2_Missense_Mutation_p.D1211H	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1208	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCTGGAGAAGACCTGAGACA	0.642													0	0	0	0.015359	0	34	89										C	72520559	G	C	72520559	3	2	1	1	0	0	0	0	1	0	0	0	259	942	33	1	3717	1	ADAMTS14	10	72520559	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		72520559	63014188	106	106										
ADK	132	broad.mit.edu	37	chr10	76285071	76285071	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	aggtggctcaccatgcttctGaaaacaacaggattttcact	8	10	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr10:76285071G>A	uc001jwi.2	+	7	685	c.613G>A	c.(613-615)GAA>AAA	p.E205K	ADK_uc010qlb.1_Intron|ADK_uc001jwj.2_Missense_Mutation_p.E188K|ADK_uc010qlc.1_Missense_Mutation_p.E170K|ADK_uc001jwl.2_5'UTR	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	205					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	CCATGCTTCTGAAAACAACAG	0.368													0	0	0	0.01441	0	87	207										A	76285071	G	A	76285071	3	1	1	1	0	0	0	0	1	0	0	0	320	1291	45	1	657	1	ADK	10	76285071	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	3764512	76285071	59249676	107	107										
GALNTL4	374378	broad.mit.edu	37	chr11	11394086	11394086	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atcccaagctccacattctcGcccccgtagacttccatgcc	5	19	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr11:11394086G>A	uc001mjo.2	-	6	1489	c.1068C>T	c.(1066-1068)GGC>GGT	p.G356G		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	356	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		CCACATTCTCGCCCCCGTAGA	0.602													0	0	0	0.001984	0	6	57										A	11394086	G	A	11394086	2	1	1	1	0	0	0	0	0	0	0	1	6223	1074	38	2		2	GALNTL4	11	11394086	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		11394086	123612430	108	108										
OR8H1	219469	broad.mit.edu	37	chr11	56058521	56058521	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atgaagtcaggcacatttgtGttatttcttctacccatgat	7	8	3	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr11:56058521G>T	uc010rje.1	-	1	18	c.18C>A	c.(16-18)AAC>AAA	p.N6K		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GCACATTTGTGTTATTTCTTC	0.358													1	0	3.73988e-18	0.00632	4.21274e-18	28	115										T	56058521	G	T	56058521	3	4	1	1	0	0	0	0	1	0	0	0	11237	1368	48	4	919	4	OR8H1	11	56058521	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	44664435	56058521	78947995	109	109										
CCDC88B	283234	broad.mit.edu	37	chr11	64123092	64123092	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ggaacacgaaacagatgccaAccgagagggtgagtggggga	17	7	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr11:64123092A>G	uc001nzy.2	+	26	4411	c.4367A>G	c.(4366-4368)AAC>AGC	p.N1456S	CCDC88B_uc001oaa.2_Missense_Mutation_p.T561A|CCDC88B_uc001oab.1_Missense_Mutation_p.N340S|CCDC88B_uc001oac.2_Missense_Mutation_p.T72A	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1456					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						ACAGATGCCAACCGAGAGGGT	0.547													0	0	0	0.004482	0	8	49										G	64123092	A	G	64123092	3	3	1	1	0	0	0	0	1	0	0	0	2864	43	2	5	4469	5	CCDC88B	11	64123092	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	8064571	64123092	70883424	110	110										
SIPA1	6494	broad.mit.edu	37	chr11	65417472	65417472	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ggacgagtggcaggccatctCggagattgcctctacttgca	13	11	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr11:65417472C>A	uc001ofb.2	+	13	2965	c.2798C>A	c.(2797-2799)TCG>TAG	p.S933*	SIPA1_uc010rom.1_Nonsense_Mutation_p.S831*|SIPA1_uc001ofd.2_Nonsense_Mutation_p.S933*	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	933					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						CAGGCCATCTCGGAGATTGCC	0.647													1	0	0.000602214	0.014758	0.000634592	5	76										A	65417472	C	A	65417472	4	1	1	1	0	0	0	0	0	1	0	0	14328	893	31	3	2844	3	SIPA1	11	65417472	Nonsense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	1294380	65417472	69589044	111	111										
TSKU	25987	broad.mit.edu	37	chr11	76506922	76506922	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cgggctacacgacgttggctGgcctggatctcagccacaac	12	14	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr11:76506922G>A	uc001oxt.2	+	2	434	c.262G>A	c.(262-264)GGC>AGC	p.G88S		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	88	LRR 2.					extracellular region					0	Ovarian(111;0.112)					GACGTTGGCTGGCCTGGATCT	0.627													0	0	0	0.004482	0	8	70										A	76506922	G	A	76506922	3	1	1	1	0	0	0	0	1	0	0	0	16624	1348	47	2	264	2	TSKU	11	76506922	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	11089450	76506922	58499594	112	112										
GRIA4	2893	broad.mit.edu	37	chr11	105774631	105774631	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	aattgatatctcaaggagagGaaatgctggggattgtctgg	14	4	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr11:105774631G>C	uc001pix.2	+	8	1423	c.977G>C	c.(976-978)GGA>GCA	p.G326A	GRIA4_uc001piu.1_Missense_Mutation_p.G326A|GRIA4_uc001piw.2_Missense_Mutation_p.G326A|GRIA4_uc009yxk.1_Missense_Mutation_p.G326A	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	326	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCAAGGAGAGGAAATGCTGGG	0.443													0	0	0	0.009718	0	45	68										C	105774631	G	C	105774631	3	2	1	1	0	0	0	0	1	0	0	0	6770	1174	41	1	1003	1	GRIA4	11	105774631	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	29267709	105774631	29231885	113	113										
SPATS2	65244	broad.mit.edu	37	chr12	49888683	49888683	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atggtgccatcaatgacactGagtctgtggactcactcagt	10	10	4	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:49888683G>A	uc001rud.2	+	7	1413	c.424G>A	c.(424-426)GAG>AAG	p.E142K	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.E142K|SPATS2_uc001ruf.2_Missense_Mutation_p.E142K|SPATS2_uc001rug.2_Missense_Mutation_p.E142K	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	142						cytoplasm				breast(1)	1						CAATGACACTGAGTCTGTGGA	0.468													0	0	0	0.008871	0	21	57										A	49888683	G	A	49888683	3	1	1	1	0	0	0	0	1	0	0	0	15018	1291	45	1	442	1	SPATS2	12	49888683	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		49888683	83963212	114	114										
SPATS2	65244	broad.mit.edu	37	chr12	49888713	49888713	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	actcactcagtgaaggtttgGagacactttcaatagatgcc	9	9	3	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:49888713G>A	uc001rud.2	+	7	1443	c.454G>A	c.(454-456)GAG>AAG	p.E152K	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.E152K|SPATS2_uc001ruf.2_Missense_Mutation_p.E152K|SPATS2_uc001rug.2_Missense_Mutation_p.E152K	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	152						cytoplasm				breast(1)	1						TGAAGGTTTGGAGACACTTTC	0.453													0	0	0	0.014323	0	22	69										A	49888713	G	A	49888713	3	1	1	1	0	0	0	0	1	0	0	0	15018	1175	41	1	472	1	SPATS2	12	49888713	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	30	49888713	83963182	115	115										
OR6C70	390327	broad.mit.edu	37	chr12	55863607	55863607	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	aaggaaaaattctgtaacccCcaagaatatgtaaaaaaaca	5	7	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:55863607C>T	uc010spn.1	-	1	316	c.316G>A	c.(316-318)GGG>AGG	p.G106R		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTGTAACCCCCAAGAATATG	0.393													0	0	0	0.004482	0	8	52										T	55863607	C	T	55863607	3	4	1	1	0	0	0	0	1	0	0	0	11197	623	22	2	624	2	OR6C70	12	55863607	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	5974894	55863607	77988288	116	116										
LRP1	4035	broad.mit.edu	37	chr12	57596297	57596297	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctacgacaacgattgcggtgAcaactccgatgaagagagct	11	10	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:57596297A>G	uc001snd.2	+	68	11154	c.10688A>G	c.(10687-10689)GAC>GGC	p.D3563G		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3563	LDL-receptor class A 26.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GATTGCGGTGACAACTCCGAT	0.652													0	0	0	0.004672	0	3	43										G	57596297	A	G	57596297	3	3	1	1	0	0	0	0	1	0	0	0	8951	275	10	5	10958	5	LRP1	12	57596297	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	1732690	57596297	76255598	117	117										
TCP11L2	255394	broad.mit.edu	37	chr12	106712243	106712243	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgtttgaagaaatcagagagGcaagttgctttgttgtctgt	12	4	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:106712243G>A	uc001tln.2	+	4	588	c.414_splice	c.e4+1	p.E138_splice	TCP11L2_uc001tll.2_Splice_Site_p.E138_splice|TCP11L2_uc001tlm.2_Splice_Site_p.E138_splice	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2											ovary(3)	3						AATCAGAGAGGCAAGTTGCTT	0.294													0	0	0	0.006214	0	9	128										A	106712243	G	A	106712243	5	1	1	1	0	0	0	0	0	0	1	0	15712	1217	42	2	425	2	TCP11L2	12	106712243	Splice_Site	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	49115946	106712243	27139652	118	118										
GPN3	51184	broad.mit.edu	37	chr12	110906002	110906002	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	catgaccagctgcgcataccGaggcatgttggctcccggag	13	13	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:110906002G>A	uc001tqr.2	-	1	63	c.7C>T	c.(7-9)CGG>TGG	p.R3W	GPN3_uc001tqs.2_Missense_Mutation_p.R3W|C12orf24_uc010sxz.1_5'Flank|C12orf24_uc009zvo.2_5'Flank|C12orf24_uc001tqt.2_5'Flank|C12orf24_uc001tqu.3_5'Flank|C12orf24_uc001tqv.3_5'Flank	NM_016301	NP_057385	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3 isoform 1	3						protein complex	GTP binding				0						TGCGCATACCGAGGCATGTTG	0.637													0	0	0	0.004656	0	26	88										A	110906002	G	A	110906002	3	1	1	1	0	0	0	0	1	0	0	0	6619	1057	37	1	909	1	GPN3	12	110906002	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	4193759	110906002	22945893	119	119										
CLIP1	6249	broad.mit.edu	37	chr12	122825944	122825944	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cagcttgcttttcaatgactCgttctctttggaaagctttt	7	9	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:122825944C>T	uc001ucg.1	-	10	1913	c.1807G>A	c.(1807-1809)GAG>AAG	p.E603K	CLIP1_uc001uch.1_Missense_Mutation_p.E592K|CLIP1_uc001uci.1_Missense_Mutation_p.E557K|CLIP1_uc001ucj.1_Missense_Mutation_p.E293K|CLIP1_uc009zxo.1_Missense_Mutation_p.E159K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	603	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTCAATGACTCGTTCTCTTTG	0.468													0	0	0	0.012319	0	22	277										T	122825944	C	T	122825944	3	4	1	1	0	0	0	0	1	0	0	0	3532	893	31	1	2573	1	CLIP1	12	122825944	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	11919942	122825944	11025951	120	120										
HIP1R	9026	broad.mit.edu	37	chr12	123342728	123342728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gggcgctgctgccgaggccgCgggcatcctgcaggatgccg	18	14	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr12:123342728C>T	uc001udj.1	+	19	1954	c.1895C>T	c.(1894-1896)GCG>GTG	p.A632V	HIP1R_uc001udk.1_5'UTR	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	632					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		GCCGAGGCCGCGGGCATCCTG	0.687													0	0	0	0.01441	0	38	19										T	123342728	C	T	123342728	3	4	1	1	0	0	0	0	1	0	0	0	7115	768	27	2	1969	2	HIP1R	12	123342728	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	516784	123342728	10509167	121	121										
TPTE2	93492	broad.mit.edu	37	chr13	20041439	20041439	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agcagaggaatcacaataatGgcagtatctaaaatgttaaa	8	5	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr13:20041439G>T	uc001umd.2	-	8	649	c.438C>A	c.(436-438)GCC>GCA	p.A146A	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	146	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TCACAATAATGGCAGTATCTA	0.313													1	0	1.06961e-07	0.00308	1.16469e-07	7	51										T	20041439	G	T	20041439	2	4	1	1	0	0	0	0	0	0	0	1	16428	1335	47	4		4	TPTE2	13	20041439	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		20041439	95128439	122	122										
SACS	26278	broad.mit.edu	37	chr13	23929791	23929791	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tctgttccgtcagcctctcgGacatataaggaaacatcctg	8	12	3	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr13:23929791G>A	uc001uon.2	-	8	1549	c.960C>T	c.(958-960)GTC>GTT	p.V320V	SACS_uc001uoo.2_Silent_p.V173V|SACS_uc001uop.1_Silent_p.V107V|SACS_uc001uoq.1_Silent_p.V173V	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	320					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CAGCCTCTCGGACATATAAGG	0.443													0	0	0	0.00499	0	16	55										A	23929791	G	A	23929791	2	1	1	1	0	0	0	0	0	0	0	1	13804	1161	41	1		1	SACS	13	23929791	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	3888352	23929791	91240087	123	123										
BRCA2	675	broad.mit.edu	37	chr13	32914782	32914782	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tagtcttcactattcacctaCgtctagacaaaatgtatcaa	4	10	5	1	rs80358866		TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr13:32914782C>T	uc001uub.1	+	11	6517	c.6290C>T	c.(6289-6291)ACG>ATG	p.T2097M		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2097					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TATTCACCTACGTCTAGACAA	0.348			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.003163	0	16	91										T	32914782	C	T	32914782	3	4	1	1	0	0	0	0	1	0	0	0	1499	536	19	2	6328	2	BRCA2	13	32914782	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	8984991	32914782	82255096	124	124										
THSD1	55901	broad.mit.edu	37	chr13	52971455	52971455	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcaaagcagtacttattcttCcccatgtcaaacaaagtaca	4	11	3	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr13:52971455C>T	uc001vgo.2	-	3	1478	c.933G>A	c.(931-933)GGG>GGA	p.G311G	THSD1_uc001vgp.2_Silent_p.G311G|THSD1_uc010tgz.1_Intron|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	311	Extracellular (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		ACTTATTCTTCCCCATGTCAA	0.448													0	0	0	0.00308	0	7	129										T	52971455	C	T	52971455	2	4	1	1	0	0	0	0	0	0	0	1	15874	842	30	1		1	THSD1	13	52971455	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	20056673	52971455	62198423	125	125										
OLFM4	10562	broad.mit.edu	37	chr13	53624617	53624617	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	taaactcaatgacaccacacTtcaggtgctaaacacttggt	6	11	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr13:53624617T>G	uc001vhl.2	+	5	1244	c.1244T>G	c.(1243-1245)CTT>CGT	p.L415R	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	415	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GACACCACACTTCAGGTGCTA	0.428													0	0	0	0.013726	0	32	140										G	53624617	T	G	53624617	3	3	1	1	0	0	0	0	1	0	0	0	10855	1609	56	5	1262	5	OLFM4	13	53624617	Missense_Mutation	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	653162	53624617	61545261	126	126										
RNF113B	140432	broad.mit.edu	37	chr13	98828998	98828998	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	catccccgaggaggagttgcCcatggacgtgtccttgggct	14	12	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr13:98828998C>T	uc001vnk.2	-	1	524	c.493G>A	c.(493-495)GGC>AGC	p.G165S	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	165							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			GAGGAGTTGCCCATGGACGTG	0.647													0	0	0	0.001168	0	5	142										T	98828998	C	T	98828998	3	4	1	1	0	0	0	0	1	0	0	0	13428	623	22	2	483	2	RNF113B	13	98828998	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	45204381	98828998	16340880	127	127										
OR4L1	122742	broad.mit.edu	37	chr14	20528885	20528885	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcctggtcagtgtaccaaaaAaatcatcacatgggctctcc	7	12	4	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr14:20528885A>C	uc001vwn.1	+	1	682	c.682A>C	c.(682-684)AAA>CAA	p.K228Q		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGTACCAAAAAAATCATCACA	0.448													0	0	0	0.014758	0	5	143										C	20528885	A	C	20528885	3	2	1	1	0	0	0	0	1	0	0	0	11074	15	1	5	684	5	OR4L1	14	20528885	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08		20528885	86820655	128	128										
SYNE2	23224	broad.mit.edu	37	chr14	64514796	64514796	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgaaaaacactgaagatgagCggaaagtcaatgagctgcaa	11	6	1	5			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr14:64514796C>T	uc001xgm.2	+	46	7530	c.7300C>T	c.(7300-7302)CGG>TGG	p.R2434W	SYNE2_uc001xgl.2_Missense_Mutation_p.R2434W	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2434	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGAAGATGAGCGGAAAGTCAA	0.323													0	0	0	0.008291	0	10	48										T	64514796	C	T	64514796	3	4	1	1	0	0	0	0	1	0	0	0	15443	759	27	2	7478	2	SYNE2	14	64514796	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	43985911	64514796	42834744	129	129										
SYNE2	23224	broad.mit.edu	37	chr14	64519446	64519446	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agaatacatgtaatgaagtgGaacacaagataaagttttgc	9	4	0	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr14:64519446G>C	uc001xgm.2	+	48	9045	c.8815G>C	c.(8815-8817)GAA>CAA	p.E2939Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E2939Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2939	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAATGAAGTGGAACACAAGAT	0.343													0	0	0	0.013537	0	13	39										C	64519446	G	C	64519446	3	2	1	1	0	0	0	0	1	0	0	0	15443	1175	41	1	9001	1	SYNE2	14	64519446	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	4650	64519446	42830094	130	130										
SPTB	6710	broad.mit.edu	37	chr14	65253698	65253698	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cgctccagccctgacaacttCctctggatggcgatgatacc	9	15	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr14:65253698C>T	uc001xht.2	-	15	3039	c.2985G>A	c.(2983-2985)AGG>AGA	p.R995R	SPTB_uc001xhr.2_Silent_p.R995R|SPTB_uc001xhs.2_Silent_p.R995R|SPTB_uc001xhu.2_Silent_p.R995R	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	995	Spectrin 7.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTGACAACTTCCTCTGGATGG	0.607													0	0	0	0.008361	0	29	82										T	65253698	C	T	65253698	2	4	1	1	0	0	0	0	0	0	0	1	15117	854	30	1		1	SPTB	14	65253698	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	734252	65253698	42095842	131	131										
SMOC1	64093	broad.mit.edu	37	chr14	70490103	70490103	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttcaccgactactgtgacctGaacaaagacaaggtcatttc	7	11	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr14:70490103G>T	uc001xls.1	+	11	1483	c.1230G>T	c.(1228-1230)CTG>CTT	p.L410L	SMOC1_uc001xlt.1_Silent_p.L410L	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	410	2 (Potential).|EF-hand 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ACTGTGACCTGAACAAAGACA	0.517													1	0	5.96743e-59	0.01441	6.9208e-59	113	127										T	70490103	G	T	70490103	2	4	1	1	0	0	0	0	0	0	0	1	14801	1277	45	3		3	SMOC1	14	70490103	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	5236405	70490103	36859437	132	132										
C14orf43	91748	broad.mit.edu	37	chr14	74194193	74194193	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	actggggtggcctcccccatCacagagaggacaggcggggt	16	12	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr14:74194193C>T	uc001xot.2	-	5	2913	c.2130G>A	c.(2128-2130)GTG>GTA	p.V710V	C14orf43_uc001xos.2_5'UTR|C14orf43_uc001xou.2_Silent_p.V710V|C14orf43_uc010tud.1_Silent_p.V710V|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	710					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		CCTCCCCCATCACAGAGAGGA	0.607													0	0	0	0.010729	0	10	40										T	74194193	C	T	74194193	2	4	1	1	0	0	0	0	0	0	0	1	1774	813	29	1		1	C14orf43	14	74194193	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	3704090	74194193	33155347	133	133										
OTUD7A	161725	broad.mit.edu	37	chr15	31795993	31795993	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtggaactcttccaggctctCgtacacggggtcctcagagt	12	12	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:31795993C>T	uc001zfq.2	-	7	994	c.901G>A	c.(901-903)GAG>AAG	p.E301K	OTUD7A_uc001zfr.2_Missense_Mutation_p.E308K	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	301	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		TCCAGGCTCTCGTACACGGGG	0.493													0	0	0	0.01441	0	52	69										T	31795993	C	T	31795993	3	4	1	1	0	0	0	0	1	0	0	0	11318	893	31	1	1899	1	OTUD7A	15	31795993	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		31795993	70735399	134	134										
RYR3	6263	broad.mit.edu	37	chr15	34105682	34105682	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tctcaggtggaacagcctttGaggtccaagaaggccgtctg	13	10	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:34105682G>A	uc001zhi.2	+	74	10474	c.10404G>A	c.(10402-10404)TTG>TTA	p.L3468L	RYR3_uc010bar.2_Silent_p.L3463L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3468					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AACAGCCTTTGAGGTCCAAGA	0.532													0	0	0	0.005443	0	26	97										A	34105682	G	A	34105682	2	1	1	1	0	0	0	0	0	0	0	1	13770	1281	45	1		1	RYR3	15	34105682	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	2309689	34105682	68425710	135	135										
UNC13C	440279	broad.mit.edu	37	chr15	54306223	54306223	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	actgcccaaatgcaaagcctCgacccatacttgtgtacttt	6	13	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:54306223C>T	uc002ack.2	+	1	1123	c.1123C>T	c.(1123-1125)CGA>TGA	p.R375*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	375					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGCAAAGCCTCGACCCATACT	0.378													0	0	0	0.008361	0	29	26										T	54306223	C	T	54306223	4	4	1	1	0	0	0	0	0	1	0	0	16983	876	31	1	1125	1	UNC13C	15	54306223	Nonsense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	20200541	54306223	48225169	136	136										
SNX22	79856	broad.mit.edu	37	chr15	64446670	64446670	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agataaagcccagccaaaggCggcctgtcaccctgctcctc	9	16	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:64446670C>G	uc002anc.1	+	7	604	c.545C>G	c.(544-546)GCG>GGG	p.A182G	SNX22_uc002amz.1_3'UTR|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	182					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						CAGCCAAAGGCGGCCTGTCAC	0.562													0	0	0	0.005524	0	34	199										G	64446670	C	G	64446670	3	3	1	1	0	0	0	0	1	0	0	0	14894	768	27	4	571	4	SNX22	15	64446670	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	10140447	64446670	38084722	137	137										
LBXCOR1	390598	broad.mit.edu	37	chr15	68121571	68121571	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gcgcggcggtggcgctggggCccgcggcctcctacgtctgc	18	16	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:68121571C>T	uc002aqy.1	+	4	2239	c.2239C>T	c.(2239-2241)CCC>TCC	p.P747S		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	791					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						GGCGCTGGGGCCCGCGGCCTC	0.706													0	0	0	0.004672	0	2	3										T	68121571	C	T	68121571	3	4	1	1	0	0	0	0	1	0	0	0	8655	739	26	2	2253	2	LBXCOR1	15	68121571	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	3674901	68121571	34409821	138	138										
MYO9A	4649	broad.mit.edu	37	chr15	72338071	72338071	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttctatatatttacctcaagTactggtccagctccaagaat	5	10	2	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:72338071T>C	uc002atl.3	-	2	1307	c.834A>G	c.(832-834)GTA>GTG	p.V278V	MYO9A_uc010biq.2_Intron|MYO9A_uc002ato.2_Silent_p.V278V|MYO9A_uc002atn.1_Silent_p.V278V	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	278	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TTACCTCAAGTACTGGTCCAG	0.303													0	0	0	0.019004	0	35	43										C	72338071	T	C	72338071	2	2	1	1	0	0	0	0	0	0	0	1	10084	1625	57	5		5	MYO9A	15	72338071	Silent	SNP	T	TCGA-BL-A0C8-01A-11D-A10S-08	4216500	72338071	30193321	139	139										
MAN2A2	4122	broad.mit.edu	37	chr15	91448546	91448546	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cttttggaggagaaccatgaGattatcagccatatcaagga	10	7	2	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:91448546G>C	uc010bnz.2	+	3	313	c.198G>C	c.(196-198)GAG>GAC	p.E66D	MAN2A2_uc010boa.2_Missense_Mutation_p.E108D|MAN2A2_uc002bqc.2_Missense_Mutation_p.E66D|MAN2A2_uc010uql.1_5'Flank|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	66	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			AGAACCATGAGATTATCAGCC	0.552													0	0	0	0.01441	0	69	65										C	91448546	G	C	91448546	3	2	1	1	0	0	0	0	1	0	0	0	9215	933	33	1	204	1	MAN2A2	15	91448546	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	19110475	91448546	11082846	140	140										
TARSL2	123283	broad.mit.edu	37	chr15	102211921	102211921	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgggttcattttccacggttCtccaaagtccatcaagctgt	8	11	3	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr15:102211921C>T	uc002bxm.2	-	14	1874	c.1819G>A	c.(1819-1821)GAA>AAA	p.E607K	TARSL2_uc002bxl.2_Missense_Mutation_p.E152K|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	607					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCACGGTTCTCCAAAGTCC	0.348													0	0	0	0.014758	0	4	83										T	102211921	C	T	102211921	3	4	1	1	0	0	0	0	1	0	0	0	15558	922	32	1	613	1	TARSL2	15	102211921	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	10763375	102211921	319471	141	141										
PTX4	390667	broad.mit.edu	37	chr16	1535988	1535988	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ttggccccctgcacaaatccGcctgctagtgcagcattggc	10	15	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr16:1535988G>A	uc010uvf.1	-	3	1374	c.1374C>T	c.(1372-1374)GGC>GGT	p.G458G		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	463	Pentaxin.					extracellular region	metal ion binding				0						GCACAAATCCGCCTGCTAGTG	0.657													0	0	0	0.004672	0	3	33										A	1535988	G	A	1535988	2	1	1	1	0	0	0	0	0	0	0	1	12823	1074	38	2		2	PTX4	16	1535988	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		1535988	88818765	142	142										
CDR2	1039	broad.mit.edu	37	chr16	22385609	22385609	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctccttcatctcaaactcctCtaccaggttttccgccagca	4	17	3	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr16:22385609C>G	uc002dkn.2	-	1	330	c.22G>C	c.(22-24)GAG>CAG	p.E8Q		NM_001802	NP_001793	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2	8						nucleus	protein binding			skin(1)	1				GBM - Glioblastoma multiforme(48;0.0188)		TCAAACTCCTCTACCAGGTTT	0.547													0	0	0	0.01892	0	22	22										G	22385609	C	G	22385609	3	3	1	1	0	0	0	0	1	0	0	0	3172	922	32	1	1362	1	CDR2	16	22385609	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	20849621	22385609	67969144	143	143										
LAT	27040	broad.mit.edu	37	chr16	28997204	28997204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	aaggggcatccagttcaaacGgcctcgtgagtacaaggagg	14	9	1	1	rs150635404	byFrequency	TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr16:28997204G>A	uc002dsd.2	+	3	510	c.158G>A	c.(157-159)CGG>CAG	p.R53Q	uc010vct.1_Intron|LAT_uc010vdj.1_Missense_Mutation_p.R89Q|LAT_uc002dsb.2_Missense_Mutation_p.R53Q|LAT_uc002dsc.2_Missense_Mutation_p.R53Q|LAT_uc010vdk.1_Missense_Mutation_p.R53Q|LAT_uc010vdl.1_Missense_Mutation_p.R53Q	NM_014387	NP_055202	O43561	LAT_HUMAN	linker for activation of T cells isoform a	53	Cytoplasmic (Potential).				calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity				0		Hepatocellular(780;0.244)				CAGTTCAAACGGCCTCGTGAG	0.607													0	0	0	0.01441	0	107	174										A	28997204	G	A	28997204	3	1	1	1	0	0	0	0	1	0	0	0	8644	1116	39	2	280	2	LAT	16	28997204	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	6611595	28997204	61357549	144	144										
B3GNT9	84752	broad.mit.edu	37	chr16	67184256	67184256	+	Frame_Shift_Del	DEL	C	C	-													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gggggtgggcctcggtgccgCcctccctcgccctcgcggcg							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr16:67184256delC	uc002erf.2	-	2	454	c.133delG	c.(133-135)GCGfs	p.A45fs	uc002erg.1_3'UTR	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	45	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0						CTCGGTGCCGCCCTCCCTCGC	0.766																		2	4	---	---								-	67184256	C	-	67184256	7	5	1	1	0	1	0	1	0	0	0	0	1264	739	26	0	1079	0	B3GNT9	16	67184256	Frame_Shift_Del	DEL	C	TCGA-BL-A0C8-01A-11D-A10S-08	38187052	67184256	23170497	145	145										
ZFHX3	463	broad.mit.edu	37	chr16	72984605	72984605	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tggaagttggccttgagctgGgtgttgtagcggcagagctt	17	6	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr16:72984605G>A	uc002fck.2	-	3	3652	c.2979C>T	c.(2977-2979)ACC>ACT	p.T993T	ZFHX3_uc002fcl.2_Silent_p.T79T	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	993	C2H2-type 7; atypical.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CCTTGAGCTGGGTGTTGTAGC	0.607													0	0	0	0.011902	0	43	33										A	72984605	G	A	72984605	2	1	1	1	0	0	0	0	0	0	0	1	17631	1219	43	2		2	ZFHX3	16	72984605	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	5800349	72984605	17370148	146	146										
MYH1	4619	broad.mit.edu	37	chr17	10411687	10411687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tattgataattacctgcttcCgctcccgttgccccaacaaa	5	14	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr17:10411687C>T	uc002gmo.2	-	16	1984	c.1890G>A	c.(1888-1890)GCG>GCA	p.A630A	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	630	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TACCTGCTTCCGCTCCCGTTG	0.338													0	0	0	0.01441	0	105	139										T	10411687	C	T	10411687	2	4	1	1	0	0	0	0	0	0	0	1	10029	639	23	2		2	MYH1	17	10411687	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		10411687	70783523	147	147										
DNAH9	1770	broad.mit.edu	37	chr17	11622799	11622799	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcaactgctcggagcagatgGattacaaggtacagttccac	10	10	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr17:11622799G>T	uc002gne.2	+	27	5769	c.5701G>T	c.(5701-5703)GAT>TAT	p.D1901Y	DNAH9_uc010coo.2_Missense_Mutation_p.D1195Y	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1901	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAGCAGATGGATTACAAGGT	0.612													1	0	6.31663e-08	0.003163	6.91653e-08	14	76										T	11622799	G	T	11622799	3	4	1	1	0	0	0	0	1	0	0	0	4608	1174	41	3	5807	3	DNAH9	17	11622799	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	1211112	11622799	69572411	148	148										
PIGW	284098	broad.mit.edu	37	chr17	34893433	34893433	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agatttgccaaaactgagctCtatgggacaggagcaatgga	12	7	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr17:34893433C>G	uc002hmy.1	+	2	526	c.483C>G	c.(481-483)CTC>CTG	p.L161L	MYO19_uc002hmw.2_5'Flank|MYO19_uc010cuu.2_5'Flank|MYO19_uc010wcy.1_5'Flank|MYO19_uc010wcz.1_5'Flank|MYO19_uc010wda.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Silent_p.L161L	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	161					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAACTGAGCTCTATGGGACAG	0.448													0	0	0	0.00623	0	38	189										G	34893433	C	G	34893433	2	3	1	1	0	0	0	0	0	0	0	1	11902	900	32	1		1	PIGW	17	34893433	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	23270634	34893433	46301777	149	149										
CNTNAP1	8506	broad.mit.edu	37	chr17	40837383	40837383	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cacgccgagggcgcccagggCgactacgtgacgctcgagct	15	15	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr17:40837383C>T	uc002iay.2	+	5	876	c.660C>T	c.(658-660)GGC>GGT	p.G220G	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	220	Laminin G-like 1.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCGCCCAGGGCGACTACGTGA	0.662													0	0	0	0.00874	0	39	39										T	40837383	C	T	40837383	2	4	1	1	0	0	0	0	0	0	0	1	3646	755	27	2		2	CNTNAP1	17	40837383	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	5943950	40837383	40357827	150	150										
NBR1	4077	broad.mit.edu	37	chr17	41342744	41342744	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gctcctctgaaccgttctgtCactcaaagtactctactcct	5	15	5	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr17:41342744C>G	uc010czd.2	+	9	954	c.814C>G	c.(814-816)CAC>GAC	p.H272D	NBR1_uc010diz.2_Missense_Mutation_p.H272D|NBR1_uc010whu.1_Missense_Mutation_p.H272D|NBR1_uc010whv.1_Missense_Mutation_p.H272D|NBR1_uc010whw.1_Missense_Mutation_p.H251D|NBR1_uc010whx.1_Missense_Mutation_p.H81D	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	272					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		ACCGTTCTGTCACTCAAAGTA	0.483													0	0	0	0.006999	0	38	30										G	41342744	C	G	41342744	3	3	1	1	0	0	0	0	1	0	0	0	10200	826	29	1	844	1	NBR1	17	41342744	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	505361	41342744	39852466	151	151										
ARSG	22901	broad.mit.edu	37	chr17	66366656	66366656	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ccttcactggattttggcaaActcgtcaaggtaaggggctc	11	10	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr17:66366656A>G	uc002jhc.2	+	8	1769	c.973A>G	c.(973-975)ACT>GCT	p.T325A	ARSG_uc002jhb.1_Missense_Mutation_p.T161A	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	325					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATTTTGGCAAACTCGTCAAGG	0.557													0	0	0	0.009096	0	4	64										G	66366656	A	G	66366656	3	3	1	1	0	0	0	0	1	0	0	0	992	43	2	5	999	5	ARSG	17	66366656	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	25023912	66366656	14828554	152	152										
KIAA1468	57614	broad.mit.edu	37	chr18	59949606	59949606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcagtatcaagaccaacattCtttgcatacagagatcataa	5	9	4	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr18:59949606C>G	uc002lil.2	+	25	3397	c.3182C>G	c.(3181-3183)TCT>TGT	p.S1061C	KIAA1468_uc010xel.1_Missense_Mutation_p.S1061C|KIAA1468_uc002lim.2_Missense_Mutation_p.S739C	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	1061							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GACCAACATTCTTTGCATACA	0.393													0	0	0	0.01441	0	72	78										G	59949606	C	G	59949606	3	3	1	1	0	0	0	0	1	0	0	0	8236	913	32	1	3280	1	KIAA1468	18	59949606	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		59949606	18127642	153	153										
LDLR	3949	broad.mit.edu	37	chr19	11224428	11224428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	caagggccatcgtggtggatCctgttcatgggtgcgtatcc	14	10	1	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr19:11224428C>T	uc002mqk.3	+	10	1744	c.1576C>T	c.(1576-1578)CCT>TCT	p.P526S	LDLR_uc010xlk.1_Missense_Mutation_p.P526S|LDLR_uc010xll.1_Missense_Mutation_p.P485S|LDLR_uc010xlm.1_Missense_Mutation_p.P379S|LDLR_uc010xln.1_Missense_Mutation_p.P399S|LDLR_uc010xlo.1_Missense_Mutation_p.P358S	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	526	Extracellular (Potential).|LDL-receptor class B 3.		P -> S (in Cincinnati-3).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CGTGGTGGATCCTGTTCATGG	0.522													0	0	0	0.009718	0	43	46										T	11224428	C	T	11224428	3	4	1	1	0	0	0	0	1	0	0	0	8704	855	30	1	1614	1	LDLR	19	11224428	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		11224428	47904555	154	154										
LRFN3	79414	broad.mit.edu	37	chr19	36431511	36431517	+	Frame_Shift_Del	DEL	CCAGCTG	CCAGCTG	-													0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcctcagctagccaacagcaCcagctgtgaccccccgcggg							TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr19:36431511_36431517delCCAGCTG	uc002oco.2	+	2	1636_1642	c.1184_1190delCCAGCTG	c.(1183-1191)ACCAGCTGTfs	p.T395fs		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	395_397	Extracellular (Potential).				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCCAACAGCACCAGCTGTGACCCCCCG	0.671																		36	68	---	---								-	36431517	CCAGCTG	-	36431511	7	5	1	1	0	1	0	1	0	0	0	0	8939	507	18	0	1186	0	LRFN3	19	36431511	Frame_Shift_Del	DEL	CCAGCTG	TCGA-BL-A0C8-01A-11D-A10S-08	25207083	36431511	22697472	155	155										
PLAUR	5329	broad.mit.edu	37	chr19	44169567	44169567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cagggtcctgttggtcttctCtgagtgggtacagcttttct	12	9	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr19:44169567C>G	uc002oxf.1	-	3	441	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	PLAUR_uc002oxd.1_Missense_Mutation_p.E71Q|PLAUR_uc002oxe.1_Missense_Mutation_p.E66Q|PLAUR_uc002oxg.1_Missense_Mutation_p.E71Q	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	71	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	TTGGTCTTCTCTGAGTGGGTA	0.547													0	0	0	0.015359	0	27	82										G	44169567	C	G	44169567	3	3	1	1	0	0	0	0	1	0	0	0	12023	922	32	1	912	1	PLAUR	19	44169567	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	7738056	44169567	14959416	156	156										
PLAUR	5329	broad.mit.edu	37	chr19	44169588	44169588	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tgagtgggtacagcttttctCcaccagctccagctcttctc	8	14	3	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr19:44169588C>G	uc002oxf.1	-	3	420	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	PLAUR_uc002oxd.1_Missense_Mutation_p.E64Q|PLAUR_uc002oxe.1_Missense_Mutation_p.E59Q|PLAUR_uc002oxg.1_Missense_Mutation_p.E64Q	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	64	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	CAGCTTTTCTCCACCAGCTCC	0.542													0	0	0	0.007291	0	26	84										G	44169588	C	G	44169588	3	3	1	1	0	0	0	0	1	0	0	0	12023	864	30	1	933	1	PLAUR	19	44169588	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	21	44169588	14959395	157	157										
ZNF221	7638	broad.mit.edu	37	chr19	44471003	44471003	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ccacaatggagaaaagccatAtaactgtgaggagtgtggta	12	6	0	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr19:44471003A>G	uc002oxx.2	+	6	1677	c.1349A>G	c.(1348-1350)TAT>TGT	p.Y450C	ZNF221_uc010ejb.1_Missense_Mutation_p.Y450C|ZNF221_uc010xws.1_Missense_Mutation_p.Y450C	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	450	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				GAAAAGCCATATAACTGTGAG	0.423													0	0	0	0.006214	0	10	83										G	44471003	A	G	44471003	3	3	1	1	0	0	0	0	1	0	0	0	17772	449	16	5	1363	5	ZNF221	19	44471003	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	301415	44471003	14657980	158	158										
GZF1	64412	broad.mit.edu	37	chr20	23351021	23351021	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	atcagtgagcttagcgagctGaccccacagacagactcgat	10	12	1	4			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr20:23351021G>C	uc010gdb.2	+	7	2253	c.2079G>C	c.(2077-2079)CTG>CTC	p.L693L	GZF1_uc002wsy.2_Silent_p.L693L|GZF1_uc010zsq.1_Silent_p.L217L|GZF1_uc010zsr.1_Silent_p.L202L|GZF1_uc002wsz.2_Silent_p.L693L	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	693					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					TTAGCGAGCTGACCCCACAGA	0.547													0	0	0	0.006999	0	40	95										C	23351021	G	C	23351021	2	2	1	1	0	0	0	0	0	0	0	1	6914	1277	45	1		1	GZF1	20	23351021	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		23351021	39674499	159	159										
SRC	6714	broad.mit.edu	37	chr20	36012573	36012573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gaccatgggtagcaacaagaGcaagcccaaggatgccagcc	12	12	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr20:36012573G>A	uc002xgx.2	+	4	466	c.17G>A	c.(16-18)AGC>AAC	p.S6N	SRC_uc002xgy.2_Missense_Mutation_p.S6N	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	6					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	AGCAACAAGAGCAAGCCCAAG	0.701													0	0	0	0.016723	0	10	10										A	36012573	G	A	36012573	3	1	1	1	0	0	0	0	1	0	0	0	15133	971	34	2	19	2	SRC	20	36012573	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	12661552	36012573	27012947	160	160										
LPIN3	64900	broad.mit.edu	37	chr20	39986944	39986944	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtgacatccagcagctgtttCtgccccacggacagcccttc	9	16	1	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr20:39986944C>T	uc002xjx.2	+	18	2351	c.2260C>T	c.(2260-2262)CTG>TTG	p.L754L	LPIN3_uc010ggh.2_Silent_p.L755L|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	754	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				GCAGCTGTTTCTGCCCCACGG	0.602													0	0	0	0.007835	0	37	49										T	39986944	C	T	39986944	2	4	1	1	0	0	0	0	0	0	0	1	8920	912	32	1		1	LPIN3	20	39986944	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	3974371	39986944	23038576	161	161										
ZNF335	63925	broad.mit.edu	37	chr20	44579219	44579219	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gtggggccgtaggcttgagtGctgtgccatgtgcgcctgca	17	10	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr20:44579219G>C	uc002xqw.2	-	21	3328	c.3205C>G	c.(3205-3207)CAC>GAC	p.H1069D	ZNF335_uc002xqv.2_Missense_Mutation_p.H181D|ZNF335_uc010zxk.1_Missense_Mutation_p.H914D	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1069	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				AGGCTTGAGTGCTGTGCCATG	0.597													0	0	0	0.00632	0	30	219										C	44579219	G	C	44579219	3	2	1	1	0	0	0	0	1	0	0	0	17849	1319	46	4	855	4	ZNF335	20	44579219	Missense_Mutation	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	4592275	44579219	18446301	162	162										
TCFL5	10732	broad.mit.edu	37	chr20	61490866	61490866	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	agcttcaagtacagaacatgAgttactagaactctggaaaa	8	7	2	3			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr20:61490866A>C	uc002ydp.2	-	3	937	c.844T>G	c.(844-846)TCA>GCA	p.S282A	TCFL5_uc002ydo.2_Missense_Mutation_p.S55A|TCFL5_uc002ydq.2_Missense_Mutation_p.S282A	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	282					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)					ACAGAACATGAGTTACTAGAA	0.368													0	0	0	0.004007	0	17	99										C	61490866	A	C	61490866	3	2	1	1	0	0	0	0	1	0	0	0	15696	304	11	5	674	5	TCFL5	20	61490866	Missense_Mutation	SNP	A	TCGA-BL-A0C8-01A-11D-A10S-08	16911647	61490866	1534654	163	163										
OPRL1	4987	broad.mit.edu	37	chr20	62724217	62724217	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cacggcgccttcctgcccctCgggctcaaggtcaccatcgt	10	18	2	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr20:62724217C>T	uc002yic.2	+	3	546	c.144C>T	c.(142-144)CTC>CTT	p.L48L	OPRL1_uc002yid.2_Silent_p.L48L|OPRL1_uc002yif.3_Silent_p.L48L	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	48	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TCCTGCCCCTCGGGCTCAAGG	0.652													0	0	0	0.01441	0	61	95										T	62724217	C	T	62724217	2	4	1	1	0	0	0	0	0	0	0	1	10886	871	31	1		1	OPRL1	20	62724217	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	1233351	62724217	301303	164	164										
KRTAP12-3	386683	broad.mit.edu	37	chr21	46078007	46078007	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	cagtcctccgtgtgcatgccCgtgagctgcacgcgcattgt	12	14	0	1			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr21:46078007C>T	uc002zft.2	+	1	159	c.111C>T	c.(109-111)CCC>CCT	p.P37P	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198697	NP_941970	P60328	KR123_HUMAN	keratin associated protein 12-3	37	5.|14 X 5 AA approximate repeats.					intermediate filament				central_nervous_system(1)	1						TGTGCATGCCCGTGAGCTGCA	0.652													0	0	0	0.00499	0	16	220										T	46078007	C	T	46078007	2	4	1	1	0	0	0	0	0	0	0	1	8520	639	23	2		2	KRTAP12-3	21	46078007	Silent	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		46078007	2051888	165	165										
FBXO7	25793	broad.mit.edu	37	chr22	32889255	32889255	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctgtggaggtttttatatctGcgtgattttcgaggtgattt	12	4	1	2			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chr22:32889255G>A	uc003amq.2	+	7	1414	c.1131G>A	c.(1129-1131)CTG>CTA	p.L377L	FBXO7_uc003amr.2_Silent_p.L263L|FBXO7_uc003ams.2_Silent_p.L221L|FBXO7_uc003amt.2_Silent_p.L298L|FBXO7_uc003amu.2_Silent_p.L263L|FBXO7_uc003amv.2_Silent_p.L76L	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	377					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						TTTTATATCTGCGTGATTTTC	0.413													0	0	0	0.008291	0	10	200										A	32889255	G	A	32889255	2	1	1	1	0	0	0	0	0	0	0	1	5760	1306	46	2		2	FBXO7	22	32889255	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08		32889255	18415311	166	166										
DCAF8L1	139425	broad.mit.edu	37	chrX	27999131	27999131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	tcctcctccccttcctcctcCatctcttcttcttcctcctc	0	23	3	0	rs148567837	byFrequency	TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chrX:27999131C>T	uc004dbx.1	-	1	436	c.321G>A	c.(319-321)ATG>ATA	p.M107I		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	107	Glu-rich.									ovary(3)|skin(1)	4						cttcctcctccatctcttctt	0.393													0	0	0	0.010504	0	22	44										T	27999131	C	T	27999131	3	4	1	1	0	0	0	0	1	0	0	0	4277	594	21	2	1485	2	DCAF8L1	23	27999131	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08		27999131	127271429	167	167										
FGD1	2245	broad.mit.edu	37	chrX	54496454	54496454	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	aacacaggtcagtacctccaCagactcctgtctctccatca	5	16	3	1	rs140078362	by1000genomes	TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chrX:54496454C>A	uc004dtg.2	-	4	1830	c.1096G>T	c.(1096-1098)GTG>TTG	p.V366L	FGD1_uc011moi.1_Missense_Mutation_p.V124L	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	366					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AGTACCTCCACAGACTCCTGT	0.423													1	0	1.15919e-05	0.008871	1.24835e-05	18	4										A	54496454	C	A	54496454	3	1	1	1	0	0	0	0	1	0	0	0	5832	478	17	4	1849	4	FGD1	23	54496454	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	26497323	54496454	100774106	168	168										
SATL1	340562	broad.mit.edu	37	chrX	84363234	84363234	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	gataaacttgattggtttgcGtctggttggctcatgtctgt	12	6	3	1	rs111730253	byFrequency	TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chrX:84363234G>A	uc011mqx.1	-	1	741	c.741C>T	c.(739-741)GAC>GAT	p.D247D	SATL1_uc004een.2_Silent_p.D247D	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	60	Gln-rich.						N-acetyltransferase activity			breast(2)	2						ATTGGTTTGCGTCTGGTTGGC	0.473													0	0	0	0.009718	0	43	97										A	84363234	G	A	84363234	2	1	1	1	0	0	0	0	0	0	0	1	13855	1136	40	2		2	SATL1	23	84363234	Silent	SNP	G	TCGA-BL-A0C8-01A-11D-A10S-08	29866780	84363234	70907326	169	169										
DCAF12L1	139170	broad.mit.edu	37	chrX	125686549	125686549	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.236686390532544	40	4.94073076988746e-08	2.48498331479422	4.95443548387097	1.54423963133641	0.528357028627496	0.700881772669127	24	ctcggcgtccgcctcgaccgCgggcgctttccgtttcctgc	12	18	0	0			TCGA-BL-A0C8-01A-11D-A10S-08	TCGA-BL-A0C8-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	134b0a5e-a0ba-444d-bc4b-bdceb02d5b04	f6f41c41-66ba-4975-89ba-044ef679332d	g.chrX:125686549C>T	uc004eul.2	-	1	294	c.43G>A	c.(43-45)GCG>ACG	p.A15T		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	15										skin(3)|ovary(1)	4						GCCTCGACCGCGGGCGCTTTC	0.512													0	0	0	0.001168	0	6	26										T	125686549	C	T	125686549	3	4	1	1	0	0	0	0	1	0	0	0	4264	768	27	2	1352	2	DCAF12L1	23	125686549	Missense_Mutation	SNP	C	TCGA-BL-A0C8-01A-11D-A10S-08	41323315	125686549	29584011	170	170										
PRDM16	63976	broad.mit.edu	37	chr1	3334507	3334507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cttcaacttccggtccccacCcccaacgctctccgacccca	4	23	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr1:3334507C>T	uc001akf.2	+	11	2887	c.2807C>T	c.(2806-2808)CCC>CTC	p.P936L	PRDM16_uc001akc.2_Missense_Mutation_p.P935L|PRDM16_uc001akd.2_Missense_Mutation_p.P935L|PRDM16_uc001ake.2_Missense_Mutation_p.P936L|PRDM16_uc009vlh.2_Missense_Mutation_p.P636L	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	936	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CGGTCCCCACCCCCAACGCTC	0.657			T	EVI1	MDS|AML								0	0	0	0.021523	0	21	36										T	3334507	C	T	3334507	3	4	2	1	0	0	0	0	1	0	0	0	12457	623	22	2	2849	2	PRDM16	1	3334507	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		3334507	245916114	1	171										
NBPF1	55672	broad.mit.edu	37	chr1	16907273	16907273	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tacagcatcctgacattcatCatgagaggattctctgtcta	7	10	4	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr1:16907273C>T	uc009vos.1	-	16	2446	c.1558G>A	c.(1558-1560)GAT>AAT	p.D520N	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Missense_Mutation_p.D249N	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	520	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGACATTCATCATGAGAGGAT	0.463													0	0	0	0.01441	0	82	652										T	16907273	C	T	16907273	3	4	2	1	0	0	0	0	1	0	0	0	10192	826	29	1	1922	1	NBPF1	1	16907273	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	13572766	16907273	232343348	2	172										
ARID1A	8289	broad.mit.edu	37	chr1	27094409	27094410	+	Frame_Shift_Del	DEL	AA	AA	-													0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gagaaggccatgggcatgacAaatctgcctgctgtgggtag							TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08			AA	-	AA	AA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr1:27094409_27094410delAA	uc001bmv.1	+	11	3490_3491	c.3117_3118delAA	c.(3115-3120)ACAAATfs	p.T1039fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.T1039fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.T1039fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.T656fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1039_1040	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGGGCATGACAAATCTGCCTGC	0.535			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													69	98	---	---								-	27094410	AA	-	27094409	7	5	2	1	0	1	0	1	0	0	0	0	913	117	5	0	3159	0	ARID1A	1	27094409	Frame_Shift_Del	DEL	AA	TCGA-BL-A13I-01A-11D-A13W-08	10187136	27094409	222156212	3	173										
OSCP1	127700	broad.mit.edu	37	chr1	36904449	36904449	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cttcttggagtagagctcttGaggcttgaataattcctcca	9	9	2	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr1:36904449G>C	uc001cap.2	-	3	287	c.205C>G	c.(205-207)CAA>GAA	p.Q69E	OSCP1_uc001caq.2_Missense_Mutation_p.Q59E|OSCP1_uc001car.2_Missense_Mutation_p.Q59E	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	69					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						TAGAGCTCTTGAGGCTTGAAT	0.468													0	0	0	0.020292	0	15	50										C	36904449	G	C	36904449	3	2	2	1	0	0	0	0	1	0	0	0	11286	1299	45	1	1160	1	OSCP1	1	36904449	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	9810040	36904449	212346172	4	174										
DISP1	84976	broad.mit.edu	37	chr1	223178660	223178660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	accactagcagctttgtccaGatccaaaacggcgtggcacc	9	14	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr1:223178660G>C	uc001hnu.1	+	8	4068	c.3921G>C	c.(3919-3921)CAG>CAC	p.Q1307H		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1307					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GCTTTGTCCAGATCCAAAACG	0.577													0	0	0	0.012319	0	18	87										C	223178660	G	C	223178660	3	2	2	1	0	0	0	0	1	0	0	0	4539	933	33	1	3947	1	DISP1	1	223178660	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	186274211	223178660	26071961	5	175										
PXDN	7837	broad.mit.edu	37	chr2	1670223	1670223	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gctctccccaaccagcacctCtgtattctgtggctggatta	8	14	3	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:1670223C>G	uc002qxa.2	-	10	1118	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q	PXDN_uc002qxb.1_Missense_Mutation_p.E352Q|PXDN_uc002qxc.1_Missense_Mutation_p.E169Q	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	352	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		ACCAGCACCTCTGTATTCTGT	0.532													0	0	0	0.00308	0	6	17										G	1670223	C	G	1670223	3	3	2	1	0	0	0	0	1	0	0	0	12847	922	32	1	3441	1	PXDN	2	1670223	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		1670223	241529150	6	176										
NRBP1	29959	broad.mit.edu	37	chr2	27656553	27656553	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttctcaggtgaatcaacggaAtgtaccaggtattgacagtg	11	7	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:27656553A>G	uc002rko.2	+	4	1056	c.224A>G	c.(223-225)AAT>AGT	p.N75S	NRBP1_uc002rkq.2_Missense_Mutation_p.N75S|NRBP1_uc002rkp.2_Missense_Mutation_p.N75S|NRBP1_uc002rkr.2_5'Flank	NM_013392	NP_037524	Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein	75	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			ovary(2)|lung(1)	3	Acute lymphoblastic leukemia(172;0.155)					AATCAACGGAATGTACCAGGT	0.418													0	0	0	0.004482	0	9	80										G	27656553	A	G	27656553	3	3	2	1	0	0	0	0	1	0	0	0	10642	101	4	5	230	5	NRBP1	2	27656553	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	25986330	27656553	215542820	7	177										
BIRC6	57448	broad.mit.edu	37	chr2	32694656	32694656	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caggaattgtacaattcggaAcagcttctcatctttccaca	6	11	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:32694656A>G	uc010ezu.2	+	30	6455	c.6321A>G	c.(6319-6321)GAA>GAG	p.E2107E		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2107					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ACAATTCGGAACAGCTTCTCA	0.388													0	0	0	0.007413	0	20	167										G	32694656	A	G	32694656	2	3	2	1	0	0	0	0	0	0	0	1	1438	40	2	5		5	BIRC6	2	32694656	Silent	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	5038103	32694656	210504717	8	178										
LTBP1	4052	broad.mit.edu	37	chr2	33500072	33500072	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gtccaacacctctgctcccaGggccgctgtgaaaacaccga	9	16	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:33500072G>C	uc002ros.2	+	17	2787	c.2787G>C	c.(2785-2787)CAG>CAC	p.Q929H	LTBP1_uc002rot.2_Missense_Mutation_p.Q603H|LTBP1_uc002rou.2_Missense_Mutation_p.Q602H|LTBP1_uc002rov.2_Missense_Mutation_p.Q549H|LTBP1_uc010ymz.1_Missense_Mutation_p.Q602H|LTBP1_uc010yna.1_Missense_Mutation_p.Q549H	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	928	EGF-like 5; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCTGCTCCCAGGGCCGCTGTG	0.438													0	0	0	0.021523	0	24	84										C	33500072	G	C	33500072	3	2	2	1	0	0	0	0	1	0	0	0	9073	991	35	4	2905	4	LTBP1	2	33500072	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	805416	33500072	209699301	9	179										
C2orf42	54980	broad.mit.edu	37	chr2	70409093	70409093	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	agataagaaagctgggacttTagtcctcagagaatttggtt	11	5	1	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:70409093T>C	uc002sgh.2	-	3	353	c.25A>G	c.(25-27)AAA>GAA	p.K9E		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	9											0						GCTGGGACTTTAGTCCTCAGA	0.438													0	0	0	0.003163	0	13	46										C	70409093	T	C	70409093	3	2	2	1	0	0	0	0	1	0	0	0	2166	1763	61	5	1731	5	C2orf42	2	70409093	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	36909021	70409093	172790280	10	180										
AFF3	3899	broad.mit.edu	37	chr2	100167951	100167951	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ggtccctatgacaggtgggcGctgttccgcagccagtgcag	15	12	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:100167951G>A	uc002tag.2	-	24	3902	c.3666C>T	c.(3664-3666)AGC>AGT	p.S1222S	AFF3_uc002taf.2_Silent_p.S1247S	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1222					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.G1222>V(1)		ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						ACAGGTGGGCGCTGTTCCGCA	0.612													0	0	0	0.001984	0	7	20										A	100167951	G	A	100167951	2	1	2	1	0	0	0	0	0	0	0	1	358	1078	38	2		2	AFF3	2	100167951	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	29758858	100167951	143031422	11	181										
GCC2	9648	broad.mit.edu	37	chr2	109102293	109102293	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttctcattctataggaaactGatcacttaatacttcaagca	4	9	4	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:109102293G>A	uc002tec.2	+	15	3875	c.3721G>A	c.(3721-3723)GAT>AAT	p.D1241N	GCC2_uc002ted.2_Missense_Mutation_p.D1140N	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1241	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						ATAGGAAACTGATCACTTAAT	0.274													0	0	0	0.004672	0	3	26										A	109102293	G	A	109102293	3	1	2	1	0	0	0	0	1	0	0	0	6286	1290	45	1	3779	1	GCC2	2	109102293	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	8934342	109102293	134097080	12	182										
XIRP2	129446	broad.mit.edu	37	chr2	168106607	168106607	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	agaaaaatgtctcgaagtcaAgggcatacaagagaaacaag	10	6	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:168106607A>G	uc002udx.2	+	8	8723	c.8705A>G	c.(8704-8706)AAG>AGG	p.K2902R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K2727R|XIRP2_uc010fpq.2_Missense_Mutation_p.K2680R|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.K248R	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2727					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTCGAAGTCAAGGGCATACAA	0.378													0	0	0	0.010729	0	12	30										G	168106607	A	G	168106607	3	3	2	1	0	0	0	0	1	0	0	0	17427	72	3	5	8735	5	XIRP2	2	168106607	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	59004314	168106607	75092766	13	183										
SSB	6741	broad.mit.edu	37	chr2	170666827	170666827	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aaagattggatgcttgctgaAattttcgggtgatttagatg	12	3	0	4			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:170666827A>C	uc002ufk.2	+	9	811	c.704A>C	c.(703-705)AAA>ACA	p.K235T	SSB_uc002ufl.2_Missense_Mutation_p.K235T|SSB_uc002ufm.2_Missense_Mutation_p.K235T	NM_003142	NP_003133	P05455	LA_HUMAN	autoantigen La	235					histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			skin(3)|pancreas(1)	4						TGCTTGCTGAAATTTTCGGGT	0.333													0	0	0	0.006214	0	10	46										C	170666827	A	C	170666827	3	2	2	1	0	0	0	0	1	0	0	0	15177	14	1	5	734	5	SSB	2	170666827	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	2560220	170666827	72532546	14	184										
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgggagaaattcacctgtctCttcatctagttgtaactgag	9	8	4	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:178098810C>T	uc002ulh.3	-	2	790	c.235G>A	c.(235-237)GAG>AAG	p.E79K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63K|NFE2L2_uc002uli.3_Missense_Mutation_p.E63K|NFE2L2_uc010fra.2_Missense_Mutation_p.E63K|NFE2L2_uc010frb.2_Missense_Mutation_p.E63K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.016522	0	23	44										T	178098810	C	T	178098810	3	4	2	1	0	0	0	0	1	0	0	0	10368	922	32	1	1598	1	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	7431983	178098810	65100563	15	185										
CCDC108	255101	broad.mit.edu	37	chr2	219884302	219884302	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aagtaactgttaagcaggtcCagagagaagaggcgccacag	13	8	0	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:219884302C>T	uc002vjl.1	-	20	3483	c.3399G>A	c.(3397-3399)CTG>CTA	p.L1133L	CCDC108_uc002vjm.3_Silent_p.L18L	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1133						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAAGCAGGTCCAGAGAGAAGA	0.622													0	0	0	0.004482	0	8	42										T	219884302	C	T	219884302	2	4	2	1	0	0	0	0	0	0	0	1	2743	581	21	2		2	CCDC108	2	219884302	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	41785492	219884302	23315071	16	186										
SPEG	10290	broad.mit.edu	37	chr2	220337742	220337742	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aagggggtccagcacatcttCcgggtcctcagcaccactgt	11	14	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr2:220337742C>T	uc010fwg.2	+	16	4071	c.4071C>T	c.(4069-4071)TTC>TTT	p.F1357F		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1357	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGCACATCTTCCGGGTCCTCA	0.672													0	0	0	0.012319	0	19	46										T	220337742	C	T	220337742	2	4	2	1	0	0	0	0	0	0	0	1	15035	854	30	1		1	SPEG	2	220337742	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	453440	220337742	22861631	17	187										
CCR5	1234	broad.mit.edu	37	chr3	46414642	46414642	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ctgtttttccttcttactgtCcccttctgggctcactatgc	6	14	3	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr3:46414642C>T	uc003cpo.3	+	3	371	c.249C>T	c.(247-249)GTC>GTT	p.V83V	CCR5_uc010hjd.2_Silent_p.V83V	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	83	Helical; Name=2; (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	TTCTTACTGTCCCCTTCTGGG	0.473													0	0	0	0.012213	0	35	162										T	46414642	C	T	46414642	2	4	2	1	0	0	0	0	0	0	0	1	2944	842	30	1		1	CCR5	3	46414642	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		46414642	151607788	18	188										
HYAL3	8372	broad.mit.edu	37	chr3	50331065	50331065	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caaaggggcaatgatcacctCagagctggagaggctcaggt	14	9	3	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr3:50331065C>G	uc003czd.1	-	3	1255	c.982G>C	c.(982-984)GAG>CAG	p.E328Q	HYAL3_uc003czc.1_Intron|HYAL3_uc003cze.1_Missense_Mutation_p.E79Q|HYAL3_uc003czf.1_Intron|HYAL3_uc003czg.1_Intron|IFRD2_uc011bdp.1_5'Flank|IFRD2_uc003czb.2_5'Flank	NM_003549	NP_003540	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3 precursor	328					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		ATGATCACCTCAGAGCTGGAG	0.587													0	0	0	0.013537	0	12	103										G	50331065	C	G	50331065	3	3	2	1	0	0	0	0	1	0	0	0	7465	835	29	1	279	1	HYAL3	3	50331065	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	3916423	50331065	147691365	19	189										
IGSF11	152404	broad.mit.edu	37	chr3	118624510	118624510	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttagaagccacgcactggtaCaaacctgaagacagggcact	10	11	0	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr3:118624510C>G	uc003ebw.2	-	5	883	c.636G>C	c.(634-636)TTG>TTC	p.L212F	IGSF11_uc011biv.1_Missense_Mutation_p.L212F|IGSF11_uc003ebx.2_Intron|IGSF11_uc003eby.2_Missense_Mutation_p.L211F|IGSF11_uc003ebz.2_Intron|IGSF11_uc010hqs.2_Missense_Mutation_p.L211F	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	212	Ig-like C2-type.|Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CGCACTGGTACAAACCTGAAG	0.468													0	0	0	0.009096	0	4	60										G	118624510	C	G	118624510	3	3	2	1	0	0	0	0	1	0	0	0	7598	477	17	4	671	4	IGSF11	3	118624510	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	68293445	118624510	79397920	20	190										
SRPRB	58477	broad.mit.edu	37	chr3	133524732	133524732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gccgggtggcagatggcggcGgtgccgggggcaccttccag	20	12	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr3:133524732G>A	uc003epx.1	+	1	56	c.40G>A	c.(40-42)GGT>AGT	p.G14S		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	14						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						AGATGGCGGCGGTGCCGGGGG	0.672													0	0	0	0.004007	0	14	49										A	133524732	G	A	133524732	3	1	2	1	0	0	0	0	1	0	0	0	15162	1116	39	2	42	2	SRPRB	3	133524732	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	14900222	133524732	64497698	21	191										
WDR49	151790	broad.mit.edu	37	chr3	167249008	167249008	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gactcccgtggtagaatggtCtgccatggggtgggagggtt	18	7	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr3:167249008C>G	uc003fev.1	-	9	1363	c.1057G>C	c.(1057-1059)GAC>CAC	p.D353H	WDR49_uc003feu.1_Missense_Mutation_p.D178H|WDR49_uc011bpd.1_Missense_Mutation_p.D417H|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	353										large_intestine(1)|ovary(1)|skin(1)	3						GTAGAATGGTCTGCCATGGGG	0.433													0	0	0	0.014758	0	4	26										G	167249008	C	G	167249008	3	3	2	1	0	0	0	0	1	0	0	0	17299	913	32	1	1064	1	WDR49	3	167249008	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	33724276	167249008	30773422	22	192										
GHSR	2693	broad.mit.edu	37	chr3	172166168	172166168	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aggtcggccagtgtgaggttGaaccccggctcttcgctggg	16	11	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr3:172166168G>C	uc003fib.1	-	1	36	c.36C>G	c.(34-36)TTC>TTG	p.F12L	GHSR_uc011bpv.1_Missense_Mutation_p.F12L	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	12	Extracellular (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GTGTGAGGTTGAACCCCGGCT	0.697													0	0	0	0.010729	0	11	23										C	172166168	G	C	172166168	3	2	2	1	0	0	0	0	1	0	0	0	6375	1281	45	1	1146	1	GHSR	3	172166168	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	4917160	172166168	25856262	23	193										
CEP135	9662	broad.mit.edu	37	chr4	56885642	56885642	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caaacagagataaagaatttCattctcacttaacctcccac	3	12	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr4:56885642C>T	uc003hbi.2	+	23	3370	c.3136C>T	c.(3136-3138)CAT>TAT	p.H1046Y	CEP135_uc003hbj.2_Missense_Mutation_p.H752Y	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	1046					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					TAAAGAATTTCATTCTCACTT	0.358													0	0	0	0.014758	0	5	23										T	56885642	C	T	56885642	3	4	2	1	0	0	0	0	1	0	0	0	3247	826	29	1	3222	1	CEP135	4	56885642	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		56885642	134268634	24	194										
CYP2U1	113612	broad.mit.edu	37	chr4	108866647	108866647	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ataatagtaacagcagttttGatgaagagtacttattttat	7	3	0	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr4:108866647G>A	uc003hyp.2	+	2	1095	c.1012G>A	c.(1012-1014)GAT>AAT	p.D338N	CYP2U1_uc011cfi.1_Missense_Mutation_p.D129N	NM_183075	NP_898898	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U,	338					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		CAGCAGTTTTGATGAAGAGTA	0.413													0	0	0	0.006122	0	18	73										A	108866647	G	A	108866647	3	1	2	1	0	0	0	0	1	0	0	0	4175	1290	45	1	1018	1	CYP2U1	4	108866647	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	51981005	108866647	82287629	25	195										
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gccatcatattgaacacagcGgactgctgcaacatgaccca	8	13	1	2	rs149680468		TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.001984	0	6	41										C	153247289	G	C	153247289	3	2	2	1	0	0	0	0	1	0	0	0	5769	1116	39	4	622	4	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	44380642	153247289	37906987	26	196										
FAT1	2195	broad.mit.edu	37	chr4	187540912	187540912	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aacacaggagggttatcattGatgtcgtctactatgatgtc	10	7	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr4:187540912G>C	uc003izf.2	-	10	7016	c.6828C>G	c.(6826-6828)ATC>ATG	p.I2276M		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2276	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGTTATCATTGATGTCGTCTA	0.493										HNSCC(5;0.00058)			0	0	0	0.008871	0	20	114										C	187540912	G	C	187540912	3	2	2	1	0	0	0	0	1	0	0	0	5689	1280	45	1	7010	1	FAT1	4	187540912	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	34293623	187540912	3613364	27	197										
CTNND2	1501	broad.mit.edu	37	chr5	11732250	11732250	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aaatgggaatgtttctacctGttctttgactgaggcgagga	12	6	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr5:11732250G>T	uc003jfa.1	-	2	317	c.172C>A	c.(172-174)CAG>AAG	p.Q58K	CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	58	Potential.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GTTTCTACCTGTTCTTTGACT	0.418													1	0	3.86212e-05	0.008291	4.08601e-05	9	47										T	11732250	G	T	11732250	3	4	2	1	0	0	0	0	1	0	0	0	4020	1386	48	4	3589	4	CTNND2	5	11732250	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		11732250	169183010	28	198										
GPR98	84059	broad.mit.edu	37	chr5	89969991	89969991	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caactcctaccagtggtgcaAgcatagatcctgaaaaggaa	9	10	0	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr5:89969991A>C	uc003kju.2	+	23	5146	c.5050A>C	c.(5050-5052)AGC>CGC	p.S1684R	GPR98_uc003kjt.2_5'UTR|GPR98_uc010jba.1_RNA	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1684	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CAGTGGTGCAAGCATAGATCC	0.423													0	0	0	0.001168	0	6	27										C	89969991	A	C	89969991	3	2	2	1	0	0	0	0	1	0	0	0	6721	72	3	5	5140	5	GPR98	5	89969991	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	78237741	89969991	90945269	29	199										
SLCO4C1	353189	broad.mit.edu	37	chr5	101592818	101592818	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aaagcactgaattgtatttaCccattatatgattcagatac	5	7	1	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr5:101592818C>T	uc003knm.2	-	8	1756	c.1469_splice	c.e8+1	p.G490_splice		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,						cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		ATTGTATTTACCCATTATATG	0.323													0	0	0	0.008291	0	10	43										T	101592818	C	T	101592818	5	4	2	1	0	0	0	0	0	0	1	0	14730	521	18	2	728	2	SLCO4C1	5	101592818	Splice_Site	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	11622827	101592818	79322442	30	200										
PCDHAC1	56135	broad.mit.edu	37	chr5	140306514	140306514	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tggcagttttatgtttgtggGtttcctgcggcgctgcagcg	15	8	0	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr5:140306514G>A	uc003lih.2	+	1	213	c.37G>A	c.(37-39)GTT>ATT	p.V13I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.V13I	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	13					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTTTGTGGGTTTCCTGCGG	0.632													0	0	0	0.014758	0	5	50										A	140306514	G	A	140306514	3	1	2	1	0	0	0	0	1	0	0	0	11532	1261	44	2	39	2	PCDHAC1	5	140306514	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	38713696	140306514	40608746	31	201										
PCDHB6	56130	broad.mit.edu	37	chr5	140531711	140531711	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	acaatggcgaggtgcgcaccGccaggctgctgagcgagcga	16	12	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr5:140531711G>T	uc003lir.2	+	1	1873	c.1873G>T	c.(1873-1875)GCC>TCC	p.A625S	PCDHB6_uc011dah.1_Missense_Mutation_p.A489S	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	625	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGCGCACCGCCAGGCTGCT	0.687													1	0	0.000308642	0.003163	0.000324185	11	45										T	140531711	G	T	140531711	3	4	2	1	0	0	0	0	1	0	0	0	11546	1087	38	4	1875	4	PCDHB6	5	140531711	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	225197	140531711	40383549	32	202										
GABRA1	2554	broad.mit.edu	37	chr5	161300148	161300148	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tacaatagatgtatttttccGtcaaagctggaaggatgaaa	9	5	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr5:161300148G>A	uc010jiw.2	+	6	749	c.281G>A	c.(280-282)CGT>CAT	p.R94H	GABRA1_uc010jix.2_Missense_Mutation_p.R94H|GABRA1_uc010jiy.2_Missense_Mutation_p.R94H|GABRA1_uc003lyx.3_Missense_Mutation_p.R94H|GABRA1_uc010jiz.2_Missense_Mutation_p.R94H|GABRA1_uc010jja.2_Missense_Mutation_p.R94H|GABRA1_uc010jjb.2_Missense_Mutation_p.R94H	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	94	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.R94H(1)		ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	GTATTTTTCCGTCAAAGCTGG	0.373													0	0	0	0.009096	0	4	35										A	161300148	G	A	161300148	3	1	2	1	0	0	0	0	1	0	0	0	6160	1145	40	2	295	2	GABRA1	5	161300148	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	20768437	161300148	19615112	33	203										
CUL9	23113	broad.mit.edu	37	chr6	43174208	43174208	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aagtgccttcccacagaattCtgtgatgcccttgaccgttt	8	12	1	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:43174208C>T	uc003ouk.2	+	26	5247	c.5172C>T	c.(5170-5172)TTC>TTT	p.F1724F	CUL9_uc003oul.2_Silent_p.F1724F|CUL9_uc010jyk.2_Silent_p.F876F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1724					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCACAGAATTCTGTGATGCCC	0.542													0	0	0	0.014323	0	22	96										T	43174208	C	T	43174208	2	4	2	1	0	0	0	0	0	0	0	1	4061	912	32	1		1	CUL9	6	43174208	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		43174208	127940859	34	204										
ZNF318	24149	broad.mit.edu	37	chr6	43305865	43305865	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttcttgttttcatcccaaacAgccaactcatagatcttttt	3	11	4	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:43305865A>T	uc003oux.2	-	10	5949	c.5871T>A	c.(5869-5871)GCT>GCA	p.A1957A	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1957					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CATCCCAAACAGCCAACTCAT	0.428													0	0	0	0.008291	0	11	83										T	43305865	A	T	43305865	2	4	2	1	0	0	0	0	0	0	0	1	17833	175	7	5		5	ZNF318	6	43305865	Silent	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	131657	43305865	127809202	35	205										
SLC35B2	347734	broad.mit.edu	37	chr6	44223092	44223092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgacagggatcaccttagagGccttggccagcacctgggtg	14	11	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:44223092G>A	uc003oxd.2	-	4	786	c.650C>T	c.(649-651)GCC>GTC	p.A217V	SLC35B2_uc011dvt.1_Missense_Mutation_p.A120V|SLC35B2_uc011dvu.1_Missense_Mutation_p.A84V	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	217					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CACCTTAGAGGCCTTGGCCAG	0.562													0	0	0	0.008871	0	20	100										A	44223092	G	A	44223092	3	1	2	1	0	0	0	0	1	0	0	0	14576	1203	42	2	652	2	SLC35B2	6	44223092	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	917227	44223092	126891975	36	206										
RUNX2	860	broad.mit.edu	37	chr6	45514577	45514577	+	Frame_Shift_Del	DEL	G	G	-													0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tttttaggtgcttcagaactGggccctttttcagaccccag							TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:45514577delG	uc011dvx.1	+	9	1311	c.1101delG	c.(1099-1101)CTGfs	p.L367fs	RUNX2_uc011dvy.1_Frame_Shift_Del_p.L345fs|RUNX2_uc003oxt.2_Frame_Shift_Del_p.L353fs	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	367	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CTTCAGAACTGGGCCCTTTTT	0.393																		15	80	---	---								-	45514577	G	-	45514577	7	5	2	1	0	1	0	1	0	0	0	0	13748	1335	47	0	1147	0	RUNX2	6	45514577	Frame_Shift_Del	DEL	G	TCGA-BL-A13I-01A-11D-A13W-08	1291485	45514577	125600490	37	207										
ENPP3	5169	broad.mit.edu	37	chr6	131979502	131979502	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atcttgttttctatggatggAtttagagctgaatatttata	8	3	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:131979502A>G	uc003qcu.3	+	7	851	c.504A>G	c.(502-504)GGA>GGG	p.G168G	ENPP3_uc010kfn.1_RNA|ENPP3_uc011ecc.1_Silent_p.G134G|ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.G168G	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	168	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CTATGGATGGATTTAGAGCTG	0.338													0	0	0	0.009096	0	3	23										G	131979502	A	G	131979502	2	3	2	1	0	0	0	0	0	0	0	1	5131	320	12	5		5	ENPP3	6	131979502	Silent	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	86464925	131979502	39135565	38	208										
SHPRH	257218	broad.mit.edu	37	chr6	146275906	146275906	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ccaccccaaatcttctaacaTttcaccactgaaggatgact	4	14	3	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:146275906T>C	uc003qlf.2	-	2	952	c.553A>G	c.(553-555)ATG>GTG	p.M185V	SHPRH_uc003qld.2_Missense_Mutation_p.M185V|SHPRH_uc003qle.2_Missense_Mutation_p.M185V|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.M74V|SHPRH_uc003qlk.1_Missense_Mutation_p.M185V	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	185				M -> V (in Ref. 3; CAH18145).	DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TCTTCTAACATTTCACCACTG	0.363													0	0	0	0.007413	0	19	46										C	146275906	T	C	146275906	3	2	2	1	0	0	0	0	1	0	0	0	14291	1493	52	5	4658	5	SHPRH	6	146275906	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	14296404	146275906	24839161	39	209										
ARID1B	57492	broad.mit.edu	37	chr6	157517418	157517418	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgggcatggggcagcgccagCagtttccctatggagccagt	15	11	0	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr6:157517418C>T	uc003qqn.2	+	16	4080	c.3928C>T	c.(3928-3930)CAG>TAG	p.Q1310*	ARID1B_uc003qqo.2_Nonsense_Mutation_p.Q1270*|ARID1B_uc003qqp.2_Nonsense_Mutation_p.Q1257*	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1315					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GCAGCGCCAGCAGTTTCCCTA	0.478													0	0	0	0.019004	0	34	167										T	157517418	C	T	157517418	4	4	2	1	0	0	0	0	0	1	0	0	914	711	25	2	4044	2	ARID1B	6	157517418	Nonsense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	11241512	157517418	13597649	40	210										
RBAK	57786	broad.mit.edu	37	chr7	5103941	5103941	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ccaccagagggctcacacagGagagaaaccttatgaatgta	10	10	1	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr7:5103941G>C	uc010kss.1	+	6	1178	c.854G>C	c.(853-855)GGA>GCA	p.G285A	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.G285A	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	285					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GCTCACACAGGAGAGAAACCT	0.418													0	0	0	0.006214	0	10	39										C	5103941	G	C	5103941	3	2	2	1	0	0	0	0	1	0	0	0	13100	1174	41	1	868	1	RBAK	7	5103941	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		5103941	154034722	41	211										
FERD3L	222894	broad.mit.edu	37	chr7	19184848	19184848	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ctcctgggtcttccctctcgGagcgcaagggctgggtcccc	13	16	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr7:19184848G>A	uc003suo.1	-	1	197	c.138C>T	c.(136-138)CTC>CTT	p.L46L	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	46					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						TTCCCTCTCGGAGCGCAAGGG	0.453													0	0	0	0.009096	0	4	44										A	19184848	G	A	19184848	2	1	2	1	0	0	0	0	0	0	0	1	5816	1161	41	1		1	FERD3L	7	19184848	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	14080907	19184848	139953815	42	212										
NPVF	64111	broad.mit.edu	37	chr7	25264765	25264765	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttttcttgtttcaattctgcAtcatctattttcttgaatag	4	7	6	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr7:25264765A>G	uc003sxo.2	-	3	614	c.567T>C	c.(565-567)GAT>GAC	p.D189D		NM_022150	NP_071433	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	189					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			ovary(1)	1						TCAATTCTGCATCATCTATTT	0.393													0	0	0	0.001168	0	6	48										G	25264765	A	G	25264765	2	3	2	1	0	0	0	0	0	0	0	1	10605	214	8	5		5	NPVF	7	25264765	Silent	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	6079917	25264765	133873898	43	213										
PAX4	5078	broad.mit.edu	37	chr7	127255466	127255466	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gcccattaccttaaggatccGtgagatgtcacagggccgca	11	12	1	1	rs35155575	byFrequency	TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr7:127255466G>A	uc010lld.1	-	1	315	c.109C>T	c.(109-111)CGG>TGG	p.R37W	PAX4_uc003vmf.2_Translation_Start_Site|PAX4_uc003vmg.1_Missense_Mutation_p.R37W|PAX4_uc003vmh.2_Translation_Start_Site	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	45	Paired.		R -> W (associated with PKD susceptbility).		cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTAAGGATCCGTGAGATGTCA	0.602													0	0	0	0.003163	0	13	107										A	127255466	G	A	127255466	3	1	2	1	0	0	0	0	1	0	0	0	11481	1144	40	2	958	2	PAX4	7	127255466	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	101990701	127255466	31883197	44	214										
MLL3	58508	broad.mit.edu	37	chr7	151949162	151949162	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atctgttggtttgtcacactCtaggtgaacccacctgcagt	9	11	3	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr7:151949162C>G	uc003wla.2	-	11	1702	c.1483G>C	c.(1483-1485)GAG>CAG	p.E495Q		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	495	PHD-type 3.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGTCACACTCTAGGTGAACC	0.378			N		medulloblastoma								0	0	0	0.014758	0	4	19										G	151949162	C	G	151949162	3	3	2	1	0	0	0	0	1	0	0	0	9622	922	32	1	13448	1	MLL3	7	151949162	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	24693696	151949162	7189501	45	215										
RAB11FIP1	80223	broad.mit.edu	37	chr8	37730530	37730530	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ctgctatgggagatgagagaGaggagaagacagaaggactc	16	5	0	6			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr8:37730530G>C	uc003xkm.1	-	4	1834	c.1790C>G	c.(1789-1791)TCT>TGT	p.S597C	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_5'UTR|RAB11FIP1_uc003xko.1_5'UTR|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	597	Ser-rich.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AGATGAGAGAGAGGAGAAGAC	0.547													0	0	0	0.004007	0	17	98										C	37730530	G	C	37730530	3	2	2	1	0	0	0	0	1	0	0	0	12893	942	33	1	2073	1	RAB11FIP1	8	37730530	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		37730530	108633492	46	216										
BAG4	9530	broad.mit.edu	37	chr8	38065264	38065264	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cccctcttagggggcaggttCcaggatatccgccttcacag	11	14	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr8:38065264C>T	uc003xky.1	+	3	895	c.613C>T	c.(613-615)CCA>TCA	p.P205S	BAG4_uc003xkz.1_Missense_Mutation_p.P169S	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	205					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				GGGGCAGGTTCCAGGATATCC	0.478													0	0	0	0.020292	0	13	78										T	38065264	C	T	38065264	3	4	2	1	0	0	0	0	1	0	0	0	1289	855	30	1	623	1	BAG4	8	38065264	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	334734	38065264	108298758	47	217										
CHD7	55636	broad.mit.edu	37	chr8	61769208	61769208	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aggcaacaagctctacctcaAatttttcatctctttcttca	3	12	6	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr8:61769208A>T	uc003xue.2	+	34	7846	c.7369A>T	c.(7369-7371)AAT>TAT	p.N2457Y		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2457					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTCTACCTCAAATTTTTCATC	0.428													0	0	0	0.006122	0	17	98										T	61769208	A	T	61769208	3	4	2	1	0	0	0	0	1	0	0	0	3330	14	1	5	7499	5	CHD7	8	61769208	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	23703944	61769208	84594814	48	218										
PKHD1L1	93035	broad.mit.edu	37	chr8	110460508	110460508	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gtgcagtgcatcgtgggagaTcatgctgggggcacatttcc	15	9	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr8:110460508T>A	uc003yne.2	+	39	6017	c.5913T>A	c.(5911-5913)GAT>GAA	p.D1971E		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1971	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCGTGGGAGATCATGCTGGGG	0.408										HNSCC(38;0.096)			0	0	0	0.009096	0	4	16										A	110460508	T	A	110460508	3	1	2	1	0	0	0	0	1	0	0	0	11972	1432	50	5	6067	5	PKHD1L1	8	110460508	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	48691300	110460508	35903514	49	219										
BNC2	54796	broad.mit.edu	37	chr9	16437456	16437456	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tccaaaccgcagaaactgctGaagggtgatgatttcctctt	9	10	1	4			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr9:16437456G>A	uc003zml.2	-	6	876	c.736C>T	c.(736-738)CAG>TAG	p.Q246*	BNC2_uc011lmw.1_Nonsense_Mutation_p.Q151*|BNC2_uc003zmm.2_Nonsense_Mutation_p.Q204*|BNC2_uc003zmq.1_Nonsense_Mutation_p.Q260*|BNC2_uc003zmr.1_Nonsense_Mutation_p.Q283*|BNC2_uc003zmp.1_Nonsense_Mutation_p.Q274*|BNC2_uc010mij.1_Nonsense_Mutation_p.Q168*|BNC2_uc011lmv.1_Nonsense_Mutation_p.Q72*|BNC2_uc003zmo.1_Nonsense_Mutation_p.Q168*|BNC2_uc003zmj.2_Nonsense_Mutation_p.Q11*|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Nonsense_Mutation_p.Q11*|BNC2_uc003zmn.1_Nonsense_Mutation_p.Q11*	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		AGAAACTGCTGAAGGGTGATG	0.498													0	0	0	0.001984	0	6	37										A	16437456	G	A	16437456	4	1	2	1	0	0	0	0	0	1	0	0	1475	1299	45	1	2571	1	BNC2	9	16437456	Nonsense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		16437456	124775975	50	220										
TNC	3371	broad.mit.edu	37	chr9	117810616	117810616	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ccataacctcatagccaatgCcagttatgaggcctctaagc	7	13	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr9:117810616C>T	uc004bjj.3	-	16	5137	c.4775G>A	c.(4774-4776)GGC>GAC	p.G1592D	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1592	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						ATAGCCAATGCCAGTTATGAG	0.498													0	0	0	0.003163	0	15	42										T	117810616	C	T	117810616	3	4	2	1	0	0	0	0	1	0	0	0	16267	739	26	2	1882	2	TNC	9	117810616	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	101373160	117810616	23402815	51	221										
NUP214	8021	broad.mit.edu	37	chr9	134026017	134026017	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ctacagattgcacactttcaGaaggagttggaagagttaaa	10	6	1	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr9:134026017G>C	uc004cag.2	+	16	2253	c.2142G>C	c.(2140-2142)CAG>CAC	p.Q714H	NUP214_uc004cah.2_Missense_Mutation_p.Q704H|NUP214_uc004cai.2_Missense_Mutation_p.Q144H|NUP214_uc004caf.1_Missense_Mutation_p.Q703H|NUP214_uc010mzf.2_Missense_Mutation_p.Q12H	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	714	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CACACTTTCAGAAGGAGTTGG	0.458			T	DEK|SET|ABL1	AML|T-ALL								0	0	0	0.004007	0	16	83										C	134026017	G	C	134026017	3	2	2	1	0	0	0	0	1	0	0	0	10762	933	33	1	2204	1	NUP214	9	134026017	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	16215401	134026017	7187414	52	222										
TTC18	118491	broad.mit.edu	37	chr10	75051185	75051185	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cattcgaatatcattgttttGaatttcatagtacaaacctg	5	7	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr10:75051185G>C	uc009xrc.2	-	20	2369	c.2248C>G	c.(2248-2250)CAA>GAA	p.Q750E	TTC18_uc001jty.2_Missense_Mutation_p.Q750E|TTC18_uc001jtv.3_5'UTR|TTC18_uc001jtw.3_5'UTR|TTC18_uc001jtx.2_Missense_Mutation_p.Q131E	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	750							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					TCATTGTTTTGAATTTCATAG	0.363													0	0	0	0.006214	0	9	61										C	75051185	G	C	75051185	3	2	2	1	0	0	0	0	1	0	0	0	16682	1299	45	1	1153	1	TTC18	10	75051185	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		75051185	60483562	53	223										
VDAC2	7417	broad.mit.edu	37	chr10	76980680	76980680	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atcaaagctgacaaggaataActttgcagtgggctacagga	11	7	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr10:76980680A>C	uc001jwz.2	+	7	695	c.536A>C	c.(535-537)AAC>ACC	p.N179T	VDAC2_uc010qld.1_Missense_Mutation_p.N140T|VDAC2_uc001jxa.2_Missense_Mutation_p.N194T|VDAC2_uc010qle.1_Missense_Mutation_p.N140T	NM_003375	NP_003366	P45880	VDAC2_HUMAN	voltage-dependent anion channel 2	179	Beta stranded; (By similarity).					mitochondrial nucleoid|mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)				Dihydroxyaluminium(DB01375)	ACAAGGAATAACTTTGCAGTG	0.473													0	0	0	0.008291	0	11	55										C	76980680	A	C	76980680	3	2	2	1	0	0	0	0	1	0	0	0	17144	43	2	5	638	5	VDAC2	10	76980680	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	1929495	76980680	58554067	54	224										
IDE	3416	broad.mit.edu	37	chr10	94269887	94269887	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ctctacttcagaaaataactTtaccaccagattagtcaagt	4	10	3	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr10:94269887T>G	uc001kia.2	-	6	893	c.817A>C	c.(817-819)AAG>CAG	p.K273Q		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	273					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding	p.K273Q(1)		ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GAAAATAACTTTACCACCAGA	0.343													0	0	0	0.004656	0	24	84										G	94269887	T	G	94269887	3	3	2	1	0	0	0	0	1	0	0	0	7493	1850	64	5	2322	5	IDE	10	94269887	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	17289207	94269887	41264860	55	225										
CYP2C9	1559	broad.mit.edu	37	chr10	96707610	96707610	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gctccattattttccataaaCgttttgattataaagatcag	5	7	1	2	rs150435881		TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr10:96707610C>T	uc001kka.3	+	4	581	c.556C>T	c.(556-558)CGT>TGT	p.R186C	CYP2C9_uc009xut.2_Missense_Mutation_p.R186C	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	186					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TTTCCATAAACGTTTTGATTA	0.373													0	0	0	0.010729	0	11	45										T	96707610	C	T	96707610	3	4	2	1	0	0	0	0	1	0	0	0	4168	536	19	2	570	2	CYP2C9	10	96707610	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	2437723	96707610	38827137	56	226										
C10orf90	118611	broad.mit.edu	37	chr10	128193175	128193175	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	accacggagctgtttctggaGaactctgtgcaggcaaaaga	12	9	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr10:128193175G>A	uc001ljq.2	-	3	715	c.594C>T	c.(592-594)TTC>TTT	p.F198F	C10orf90_uc001ljp.2_Silent_p.F151F|C10orf90_uc010qum.1_Silent_p.F295F|C10orf90_uc009yao.2_Silent_p.F295F|C10orf90_uc001ljs.1_Silent_p.F151F	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	198										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TGTTTCTGGAGAACTCTGTGC	0.602											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	23	123										A	128193175	G	A	128193175	2	1	2	1	0	0	0	0	0	0	0	1	1623	933	33	1		1	C10orf90	10	128193175	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	31485565	128193175	7341572	57	227										
USP47	55031	broad.mit.edu	37	chr11	11954622	11954622	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aagagagagagttggaagaaCaagaaaagagacaacgagaa	13	3	0	6			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:11954622C>G	uc001mjq.1	+	16	2546	c.1783C>G	c.(1783-1785)CAA>GAA	p.Q595E	USP47_uc001mjr.2_Missense_Mutation_p.Q507E|USP47_uc001mjs.2_Missense_Mutation_p.Q575E	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	595					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		GTTGGAAGAACAAGAAAAGAG	0.338													0	0	0	0.004672	0	2	10										G	11954622	C	G	11954622	3	3	2	1	0	0	0	0	1	0	0	0	17075	479	17	4	1573	4	USP47	11	11954622	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		11954622	123051894	58	228										
MRGPRX2	117194	broad.mit.edu	37	chr11	19077796	19077796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gcggaagcccaggagccagaGcacaaacccgtttcctacca	10	15	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:19077796G>A	uc001mph.2	-	2	242	c.154C>T	c.(154-156)CTC>TTC	p.L52F		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	52	Helical; Name=1; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						AGGAGCCAGAGCACAAACCCG	0.572													0	0	0	0.007291	0	30	131										A	19077796	G	A	19077796	3	1	2	1	0	0	0	0	1	0	0	0	9767	971	34	2	842	2	MRGPRX2	11	19077796	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	7123174	19077796	115928720	59	229										
MS4A8B	83661	broad.mit.edu	37	chr11	60468502	60468502	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cacctagtttggtgtcgaatGtgaatgggcagcctgtgcag	14	8	0	1	rs148191741	byFrequency	TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:60468502G>A	uc001npv.2	+	2	372	c.169G>A	c.(169-171)GTG>ATG	p.V57M	MS4A8B_uc009yne.1_Missense_Mutation_p.V57M	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	57	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GGTGTCGAATGTGAATGGGCA	0.532													0	0	0	0.010729	0	11	58										A	60468502	G	A	60468502	3	1	2	1	0	0	0	0	1	0	0	0	9867	1377	48	2	171	2	MS4A8B	11	60468502	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	41390706	60468502	74538014	60	230										
SART1	9092	broad.mit.edu	37	chr11	65729273	65729273	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tggggtcgtccaagaagcatCgcggagagaaggaggcggcc	18	9	0	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:65729273C>G	uc001ogl.2	+	1	114	c.22C>G	c.(22-24)CGC>GGC	p.R8G	SART1_uc009yqy.1_Missense_Mutation_p.R8G|SART1_uc010rot.1_Translation_Start_Site	NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	8					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1						CAAGAAGCATCGCGGAGAGAA	0.348													0	0	0	0.004482	0	8	15										G	65729273	C	G	65729273	3	3	2	1	0	0	0	0	1	0	0	0	13846	884	31	1	24	1	SART1	11	65729273	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	5260771	65729273	69277243	61	231										
BBS1	582	broad.mit.edu	37	chr11	66282016	66282016	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	catggagcaacatgagccccGgaccccagctctggcacttg	11	15	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:66282016G>A	uc001oij.1	+	4	311	c.299G>A	c.(298-300)CGG>CAG	p.R100Q	BBS1_uc001oii.1_Missense_Mutation_p.R137Q|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Missense_Mutation_p.R100Q|BBS1_uc001oik.1_Missense_Mutation_p.R24Q|BBS1_uc001oil.1_Missense_Mutation_p.R100Q	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	100					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						CATGAGCCCCGGACCCCAGCT	0.562									Bardet-Biedl_syndrome				0	0	0	0.01441	0	50	205										A	66282016	G	A	66282016	3	1	2	1	0	0	0	0	1	0	0	0	1335	1116	39	2	313	2	BBS1	11	66282016	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	552743	66282016	68724500	62	232										
GPR152	390212	broad.mit.edu	37	chr11	67219578	67219578	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	acgtggcagacgagcagcagGaggaaaggcaggaagccccc	16	11	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:67219578G>C	uc001olm.2	-	1	623	c.618C>G	c.(616-618)CTC>CTG	p.L206L	uc009yrw.1_5'Flank|CABP4_uc001oln.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	206	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CGAGCAGCAGGAGGAAAGGCA	0.677													0	0	0	0.006214	0	9	45										C	67219578	G	C	67219578	2	2	2	1	0	0	0	0	0	0	0	1	6658	1161	41	1		1	GPR152	11	67219578	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	937562	67219578	67786938	63	233										
OPCML	4978	broad.mit.edu	37	chr11	132527208	132527209	+	Missense_Mutation	DNP	GG	GG	TT													0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cgggttacccggtcatctatGgtacacctgcagtgaggcag							TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr11:132527208_132527209GG>TT	uc001qgs.2	-	2	223_224	c.173_174CC>AA	c.(172-174)ACC>AAA	p.T58K	OPCML_uc001qgu.2_Missense_Mutation_p.T51K|OPCML_uc010sck.1_Missense_Mutation_p.T58K|OPCML_uc001qgt.2_Missense_Mutation_p.T58K|OPCML_uc010scl.1_Missense_Mutation_p.T17K	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	58	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GGTCATCTATGGTACACCTGCA	0.515													0	0	0	0.004672	0	8	40										TT	132527209	GG	TT	132527208	3	4	2	1	0	0	0	0	1	0	0	0	10874	1335	47	4	887	4	OPCML	11	132527208	Missense_Mutation	DNP	GG	TCGA-BL-A13I-01A-11D-A13W-08	65307630	132527208	2479308	64	234										
CD163	9332	broad.mit.edu	37	chr12	7635262	7635262	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caagccgctgtctctgtcttCgctttttagtcaagaagaat	8	10	3	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:7635262C>T	uc001qsz.3	-	14	3352	c.3224G>A	c.(3223-3225)CGA>CAA	p.R1075Q	CD163_uc001qta.3_Missense_Mutation_p.R1075Q|CD163_uc009zfw.2_Missense_Mutation_p.R1108Q	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1075	Cytoplasmic (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TCTCTGTCTTCGCTTTTTAGT	0.433													0	0	0	0.010504	0	16	86										T	7635262	C	T	7635262	3	4	2	1	0	0	0	0	1	0	0	0	2967	884	31	1	258	1	CD163	12	7635262	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		7635262	126216633	65	235										
RIMKLB	57494	broad.mit.edu	37	chr12	8902643	8902643	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ataagttctggacatttcaaGagttggctggccatggtgtt	12	6	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:8902643G>A	uc001quu.2	+	3	612	c.361G>A	c.(361-363)GAG>AAG	p.E121K	RIMKLB_uc009zgf.1_RNA|RIMKLB_uc001qux.2_Missense_Mutation_p.E121K|RIMKLB_uc010sgl.1_Missense_Mutation_p.E121K|RIMKLB_uc001quw.2_Missense_Mutation_p.E121K	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	121	ATP-grasp.				protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						GACATTTCAAGAGTTGGCTGG	0.433													0	0	0	0.00308	0	7	66										A	8902643	G	A	8902643	3	1	2	1	0	0	0	0	1	0	0	0	13366	943	33	1	367	1	RIMKLB	12	8902643	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	1267381	8902643	124949252	66	236										
FAM186B	84070	broad.mit.edu	37	chr12	49997129	49997129	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cttcactcttcctgggcccaAtctcataggtcagagtgtca	8	13	5	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:49997129A>G	uc001ruo.2	-	3	517	c.344T>C	c.(343-345)ATT>ACT	p.I115T	FAM186B_uc010smk.1_Missense_Mutation_p.I25T	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	115						protein complex				ovary(1)	1						CCTGGGCCCAATCTCATAGGT	0.557													0	0	0	0.008291	0	11	53										G	49997129	A	G	49997129	3	3	2	1	0	0	0	0	1	0	0	0	5512	101	4	5	2357	5	FAM186B	12	49997129	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	41094486	49997129	83854766	67	237										
PIP4K2C	79837	broad.mit.edu	37	chr12	57992888	57992888	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caacacgcttctgccccagtTcctggggatgtaccgagtca	10	14	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:57992888T>A	uc001sou.2	+	5	685	c.554T>A	c.(553-555)TTC>TAC	p.F185Y	PIP4K2C_uc001sot.2_Missense_Mutation_p.F185Y|PIP4K2C_uc010srs.1_Missense_Mutation_p.F167Y|PIP4K2C_uc010srt.1_Missense_Mutation_p.F137Y	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	185	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					CTGCCCCAGTTCCTGGGGATG	0.517													0	0	0	0.020292	0	14	80										A	57992888	T	A	57992888	3	1	2	1	0	0	0	0	1	0	0	0	11938	1783	62	5	572	5	PIP4K2C	12	57992888	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	7995759	57992888	75859007	68	238										
CAMKK2	10645	broad.mit.edu	37	chr12	121693608	121693608	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttggttgaccagttcgaacaCtgtagggaagaaaagggtga	14	5	0	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:121693608C>T	uc001tzu.2	-	8	921	c.797_splice	c.e8-1	p.V266_splice	CAMKK2_uc001tzt.2_Splice_Site_p.V266_splice|CAMKK2_uc001tzv.2_Splice_Site_p.V266_splice|CAMKK2_uc001tzw.2_Splice_Site_p.V266_splice|CAMKK2_uc001tzx.2_Splice_Site_p.V266_splice|CAMKK2_uc001tzy.2_Splice_Site_p.V266_splice|CAMKK2_uc001tzz.1_Splice_Site_p.V53_splice|CAMKK2_uc001uaa.1_Splice_Site_p.V266_splice|CAMKK2_uc001uab.2_Splice_Site_p.V266_splice|CAMKK2_uc001uac.2_Splice_Site_p.V266_splice	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase						calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGTTCGAACACTGTAGGGAAG	0.527													0	0	0	0.001984	0	6	30										T	121693608	C	T	121693608	5	4	2	1	0	0	0	0	0	0	1	0	2607	579	20	2	1020	2	CAMKK2	12	121693608	Splice_Site	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	63700720	121693608	12158287	69	239										
KNTC1	9735	broad.mit.edu	37	chr12	123067479	123067479	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caagagctggaggcagagctGaccttgagagccttaaaaga	13	8	0	5			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:123067479G>C	uc001ucv.2	+	34	3373	c.3210G>C	c.(3208-3210)CTG>CTC	p.L1070L	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1070					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AGGCAGAGCTGACCTTGAGAG	0.488													0	0	0	0.004672	0	3	23										C	123067479	G	C	123067479	2	2	2	1	0	0	0	0	0	0	0	1	8428	1277	45	1		1	KNTC1	12	123067479	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	1373871	123067479	10784416	70	240										
DNAH10	196385	broad.mit.edu	37	chr12	124416629	124416629	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	actggatggtctacttcctgCggcggttcagccagtacatg	12	11	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr12:124416629C>A	uc001uft.3	+	75	12941	c.12916C>A	c.(12916-12918)CGG>AGG	p.R4306R	DNAH10_uc001ufu.3_Silent_p.R219R	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4306					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTACTTCCTGCGGCGGTTCAG	0.532													1	0	1.08611e-07	0.010729	1.16597e-07	12	71										A	124416629	C	A	124416629	2	1	2	1	0	0	0	0	0	0	0	1	4598	759	27	4		4	DNAH10	12	124416629	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	1349150	124416629	9435266	71	241										
MPHOSPH8	54737	broad.mit.edu	37	chr13	20224169	20224169	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aggaaatcagaaatgcatttGatttatttaaattaactcca	5	5	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr13:20224169G>C	uc001umh.2	+	5	1354	c.1345G>C	c.(1345-1347)GAT>CAT	p.D449H	MPHOSPH8_uc001umg.2_Missense_Mutation_p.D449H|MPHOSPH8_uc001umi.2_Missense_Mutation_p.D146H	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	449					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		AAATGCATTTGATTTATTTAA	0.279													0	0	0	0.014758	0	5	30										C	20224169	G	C	20224169	3	2	2	1	0	0	0	0	1	0	0	0	9727	1290	45	1	1363	1	MPHOSPH8	13	20224169	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		20224169	94945709	72	242										
FREM2	341640	broad.mit.edu	37	chr13	39266204	39266204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgaaattcactatcacccagGtgcctattcatggccatctc	6	13	4	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr13:39266204G>A	uc001uwv.2	+	1	5032	c.4723G>A	c.(4723-4725)GTG>ATG	p.V1575M		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1575	Extracellular (Potential).|CSPG 11.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TATCACCCAGGTGCCTATTCA	0.418													0	0	0	0.003163	0	16	103										A	39266204	G	A	39266204	3	1	2	1	0	0	0	0	1	0	0	0	6045	1261	44	2	4725	2	FREM2	13	39266204	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	19042035	39266204	75903674	73	243										
KIAA0564	23078	broad.mit.edu	37	chr13	42442585	42442585	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caatctctttaggaagtagaGagcttcctgaatcttgaagt	9	7	2	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr13:42442585G>C	uc001uyj.2	-	10	1179	c.1109C>G	c.(1108-1110)TCT>TGT	p.S370C	KIAA0564_uc001uyk.2_Missense_Mutation_p.S370C	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	370						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		AGGAAGTAGAGAGCTTCCTGA	0.368													0	0	0	0.008291	0	11	62										C	42442585	G	C	42442585	3	2	2	1	0	0	0	0	1	0	0	0	8185	942	33	1	4756	1	KIAA0564	13	42442585	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	3176381	42442585	72727293	74	244										
PCDH17	27253	broad.mit.edu	37	chr13	58208888	58208888	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgcaagcgcgagaacaaggaGatccgcacttacaactgccg	11	12	0	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr13:58208888G>C	uc001vhq.1	+	1	3100	c.2208G>C	c.(2206-2208)GAG>GAC	p.E736D	PCDH17_uc010aec.1_Missense_Mutation_p.E736D	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	736	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGAACAAGGAGATCCGCACTT	0.552													0	0	0	0.001984	0	6	49										C	58208888	G	C	58208888	3	2	2	1	0	0	0	0	1	0	0	0	11512	933	33	1	2210	1	PCDH17	13	58208888	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	15766303	58208888	56960990	75	245										
COMMD6	170622	broad.mit.edu	37	chr13	76104396	76104396	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	acccagtttccactgaaaatCtacaagctttaataagacag	5	10	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr13:76104396C>G	uc001vjo.1	-	3	111	c.61G>C	c.(61-63)GAT>CAT	p.D21H	COMMD6_uc001vjn.1_Missense_Mutation_p.D21H|COMMD6_uc010aet.1_RNA|COMMD6_uc001vjp.1_Splice_Site	NM_203495	NP_987091	Q7Z4G1	COMD6_HUMAN	COMM domain containing 6 isoform b	21	COMM.					cytoplasm|nucleus	protein binding				0		Breast(118;0.0979)|Prostate(6;0.122)		GBM - Glioblastoma multiforme(99;0.0104)		CACTGAAAATCTACAAGCTTT	0.363													0	0	0	0.006214	0	10	67										G	76104396	C	G	76104396	3	3	2	1	0	0	0	0	1	0	0	0	3720	913	32	1	247	1	COMMD6	13	76104396	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	17895508	76104396	39065482	76	246										
FOS	2353	broad.mit.edu	37	chr14	75747297	75747297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	agaagagaaaaggagaatccGaagggaaaggaataagatgg	15	2	0	4			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr14:75747297G>A	uc001xrn.2	+	3	633	c.428G>A	c.(427-429)CGA>CAA	p.R143Q	FOS_uc010tva.1_Intron|FOS_uc010asi.2_Missense_Mutation_p.R29Q|FOS_uc001xro.2_5'UTR	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene	143	Basic motif.			SPEEEEKRRIRR -> ISRRRREKENPK (in Ref. 6; no nucleotide entry).	cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		AGGAGAATCCGAAGGGAAAGG	0.468													0	0	0	0.001168	0	6	40										A	75747297	G	A	75747297	3	1	2	1	0	0	0	0	1	0	0	0	5985	1058	37	1	438	1	FOS	14	75747297	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		75747297	31602243	77	247										
ATP10A	57194	broad.mit.edu	37	chr15	25963405	25963405	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cccggctgcccgtgcgccggTgggacttggtgctctgggtt	17	13	1	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr15:25963405T>A	uc010ayu.2	-	8	1611	c.1505A>T	c.(1504-1506)CAC>CTC	p.H502L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	502	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CGTGCGCCGGTGGGACTTGGT	0.687													0	0	0	0.014758	0	4	22										A	25963405	T	A	25963405	3	1	2	1	0	0	0	0	1	0	0	0	1116	1696	59	5	3050	5	ATP10A	15	25963405	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08		25963405	76567987	78	248										
CATSPER2	117155	broad.mit.edu	37	chr15	43940187	43940187	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atgctcaatgagagagaaagTatcgatgagacgtgaacgaa	12	5	1	4			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr15:43940187T>C	uc001zsh.2	-	2	288	c.73A>G	c.(73-75)ACT>GCT	p.T25A	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Missense_Mutation_p.T25A|CATSPER2_uc001zsj.2_Missense_Mutation_p.T25A|CATSPER2_uc001zsk.2_Missense_Mutation_p.T25A|CATSPER2_uc001zsl.1_Intron	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	25	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AGAGAGAAAGTATCGATGAGA	0.473													0	0	0	0.01441	0	55	282										C	43940187	T	C	43940187	3	2	2	1	0	0	0	0	1	0	0	0	2688	1638	57	5	1606	5	CATSPER2	15	43940187	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	17976782	43940187	58591205	79	249										
HERC1	8925	broad.mit.edu	37	chr15	63970057	63970057	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atcatacctgatagtaatttCtgcttcatcccattggacct	5	11	3	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr15:63970057C>G	uc002amp.2	-	37	7205	c.7057G>C	c.(7057-7059)GAA>CAA	p.E2353Q		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2353					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ATAGTAATTTCTGCTTCATCC	0.458													0	0	0	0.004656	0	26	104										G	63970057	C	G	63970057	3	3	2	1	0	0	0	0	1	0	0	0	7057	922	32	1	7696	1	HERC1	15	63970057	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	20029870	63970057	38561335	80	250										
IL16	3603	broad.mit.edu	37	chr15	81592687	81592687	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atccttgctgtgccttccatCttctatctcctgtgcccaga	6	15	3	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr15:81592687C>G	uc002bgh.3	+	14	3396	c.3020C>G	c.(3019-3021)TCT>TGT	p.S1007C	IL16_uc010blq.1_Missense_Mutation_p.S961C|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.S1049C|IL16_uc002bgg.2_Missense_Mutation_p.S1007C|IL16_uc002bgi.1_Missense_Mutation_p.S397C|IL16_uc002bgj.2_Missense_Mutation_p.S501C|IL16_uc002bgk.2_Missense_Mutation_p.S306C|IL16_uc002bgl.1_Missense_Mutation_p.S306C|IL16_uc010unq.1_Missense_Mutation_p.S306C	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	1007					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						TGCCTTCCATCTTCTATCTCC	0.493													0	0	0	0.008871	0	20	101										G	81592687	C	G	81592687	3	3	2	1	0	0	0	0	1	0	0	0	7633	913	32	1	3070	1	IL16	15	81592687	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	17622630	81592687	20938705	81	251										
PCSK6	5046	broad.mit.edu	37	chr15	101906530	101906530	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aaacccttcattggaaagatCcagcaacctgcaattggagg	9	10	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr15:101906530C>T	uc002bwy.2	-	14	2043	c.1729G>A	c.(1729-1731)GAT>AAT	p.D577N	PCSK6_uc010bpd.2_Missense_Mutation_p.D373N|PCSK6_uc010bpe.2_Missense_Mutation_p.D577N|PCSK6_uc002bxa.2_Missense_Mutation_p.D577N|PCSK6_uc002bxb.2_Missense_Mutation_p.D577N|PCSK6_uc002bxc.1_Missense_Mutation_p.D577N|PCSK6_uc002bxd.1_Missense_Mutation_p.D577N|PCSK6_uc002bxe.2_Missense_Mutation_p.D577N|PCSK6_uc002bxf.1_Missense_Mutation_p.D77N	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	577	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTGGAAAGATCCAGCAACCTG	0.542													0	0	0	0.001168	0	6	41										T	101906530	C	T	101906530	3	4	2	1	0	0	0	0	1	0	0	0	11604	855	30	1	1649	1	PCSK6	15	101906530	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	20313843	101906530	624862	82	252										
PDXDC1	23042	broad.mit.edu	37	chr16	15110963	15110989	+	Splice_Site	DEL	GTTTTTTCTTCCAGTGTGAATCTGGCA	GTTTTTTCTTCCAGTGTGAATCTGGCA	-													0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	taattagttcttggactggtGttttttcttccagtgtgaat					rs3205773		TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:15110963_15110989delGTTTTTTCTTCCAGTGTGAATCTGGCA	uc002dda.3	+	10	1037	c.813_splice	c.e10-1	p.G271_splice	PDXDC1_uc010uzl.1_Splice_Site_p.G256_splice|PDXDC1_uc010uzm.1_Splice_Site_p.G180_splice|PDXDC1_uc002dcz.2_Splice_Site_p.G248_splice|PDXDC1_uc002ddb.3_Splice_Site_p.G244_splice|PDXDC1_uc010uzn.1_Splice_Site_p.G243_splice|PDXDC1_uc002ddc.2_Splice_Site_p.G271_splice	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain						carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	TTGGACTGGTGTTTTTTCTTCCAGTGTGAATCTGGCAACATTGGCTC	0.348																		8	702	---	---								-	15110989	GTTTTTTCTTCCAGTGTGAATCTGGCA	-	15110963	8	5	2	1	0	1	0	1	0	0	1	0	11696	1392	48	0		0	PDXDC1	16	15110963	Splice_Site	DEL	GTTTTTTCTTCCAGTGTGAATCTGGCA	TCGA-BL-A13I-01A-11D-A13W-08		15110963	75243790	83	253										
SLC5A11	115584	broad.mit.edu	37	chr16	24920408	24920408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tggttcacagagccaccctcCaaggagatggtacatttggg	12	10	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:24920408C>T	uc002dmu.2	+	14	1873	c.1641C>T	c.(1639-1641)TCC>TCT	p.S547S	SLC5A11_uc002dms.2_Silent_p.S483S|SLC5A11_uc010vcd.1_Silent_p.S512S|SLC5A11_uc002dmt.2_Silent_p.S391S|SLC5A11_uc010vce.1_Silent_p.S477S|SLC5A11_uc010bxt.2_Silent_p.S483S|SLC5A11_uc002dmv.2_Silent_p.S170S	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	547	Cytoplasmic (Potential).			S -> P (in Ref. 5; BAC86105).	apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		AGCCACCCTCCAAGGAGATGG	0.363													0	0	0	0.003163	0	15	91										T	24920408	C	T	24920408	2	4	2	1	0	0	0	0	0	0	0	1	14663	581	21	2		2	SLC5A11	16	24920408	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	9809445	24920408	65434345	84	254										
ATXN2L	11273	broad.mit.edu	37	chr16	28847397	28847397	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cagagtggggtgcctgcactCtcagcttccacaccctcacc	9	17	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:28847397C>G	uc002drc.2	+	22	3207	c.3039C>G	c.(3037-3039)CTC>CTG	p.L1013L	uc010vct.1_Intron|ATXN2L_uc002drb.2_Silent_p.L1013L|ATXN2L_uc002dqy.2_Silent_p.L1013L|ATXN2L_uc002dra.2_Silent_p.L1013L|ATXN2L_uc002dqz.2_Silent_p.L1013L|ATXN2L_uc010vdb.1_Silent_p.L1019L|ATXN2L_uc002dre.2_Silent_p.L1013L|ATXN2L_uc002drf.2_Silent_p.L422L|ATXN2L_uc002drg.2_Silent_p.L296L	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	1013						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TGCCTGCACTCTCAGCTTCCA	0.682													0	0	0	0.004007	0	15	92										G	28847397	C	G	28847397	2	3	2	1	0	0	0	0	0	0	0	1	1212	900	32	1		1	ATXN2L	16	28847397	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	3926989	28847397	61507356	85	255			1	1		2	2	18	C		6.58963e-05
ATXN2L	11273	broad.mit.edu	37	chr16	28847414	28847414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	actctcagcttccacaccctCaccctacccctacatcggac	3	21	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:28847414C>T	uc002drc.2	+	22	3224	c.3056C>T	c.(3055-3057)TCA>TTA	p.S1019L	uc010vct.1_Intron|ATXN2L_uc002drb.2_Missense_Mutation_p.S1019L|ATXN2L_uc002dqy.2_Missense_Mutation_p.S1019L|ATXN2L_uc002dra.2_Missense_Mutation_p.S1019L|ATXN2L_uc002dqz.2_Missense_Mutation_p.S1019L|ATXN2L_uc010vdb.1_Missense_Mutation_p.S1025L|ATXN2L_uc002dre.2_Missense_Mutation_p.S1019L|ATXN2L_uc002drf.2_Missense_Mutation_p.S428L|ATXN2L_uc002drg.2_Missense_Mutation_p.S302L	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	1019						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCCACACCCTCACCCTACCCC	0.647													0	0	0	0.016522	0	21	93										T	28847414	C	T	28847414	3	4	2	1	0	0	0	0	1	0	0	0	1212	838	29	1	3142	1	ATXN2L	16	28847414	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	17	28847414	61507339	86	256			1	1		2	2	18	C		6.58963e-05
CIAPIN1	57019	broad.mit.edu	37	chr16	57468081	57468081	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tttcatgaccaaggtgttctCgaacagactgtacttcctca	7	11	3	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:57468081C>T	uc002ell.1	-	5	602	c.431G>A	c.(430-432)CGA>CAA	p.R144Q	CIAPIN1_uc002elk.1_RNA|CIAPIN1_uc002elm.1_Missense_Mutation_p.R131Q|CIAPIN1_uc002eln.1_Missense_Mutation_p.R144Q|CIAPIN1_uc010cda.1_Missense_Mutation_p.R144Q|CIAPIN1_uc002elo.1_Missense_Mutation_p.R117Q|CIAPIN1_uc010vhm.1_Missense_Mutation_p.R144Q	NM_020313	NP_064709	Q6FI81	CPIN1_HUMAN	cytokine induced apoptosis inhibitor 1	144					anti-apoptosis|apoptosis	cytoplasm|nucleolus					0						AAGGTGTTCTCGAACAGACTG	0.448													0	0	0	0.021523	0	25	158										T	57468081	C	T	57468081	3	4	2	1	0	0	0	0	1	0	0	0	3419	884	31	1	527	1	CIAPIN1	16	57468081	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	28620667	57468081	32886672	87	257										
CDH16	1014	broad.mit.edu	37	chr16	66944181	66944181	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	accattgagagtctggaggcGccaatcccgttgcaccgtgg	13	12	1	1	rs140255974		TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:66944181G>A	uc002eql.2	-	15	2222	c.2149C>T	c.(2149-2151)CGC>TGC	p.R717C	CDH16_uc010cdy.2_Missense_Mutation_p.R695C|CDH16_uc002eqm.2_Missense_Mutation_p.R620C	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	717	Extracellular (Potential).|Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTCTGGAGGCGCCAATCCCGT	0.612													0	0	0	0.007413	0	18	61										A	66944181	G	A	66944181	3	1	2	1	0	0	0	0	1	0	0	0	3101	1087	38	2	356	2	CDH16	16	66944181	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	9476100	66944181	23410572	88	258										
KLHL36	79786	broad.mit.edu	37	chr16	84684521	84684521	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gtgtctcggccatacaagatCagcgaatcatcaaaggtctg	10	10	5	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr16:84684521C>T	uc002fig.2	+	2	189	c.48C>T	c.(46-48)ATC>ATT	p.I16I	KLHL36_uc010chl.2_Silent_p.I15I	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	16										skin(2)	2						CATACAAGATCAGCGAATCAT	0.438													0	0	0	0.010729	0	12	83										T	84684521	C	T	84684521	2	4	2	1	0	0	0	0	0	0	0	1	8389	816	29	1		1	KLHL36	16	84684521	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	17740340	84684521	5670232	89	259										
FAM57A	79850	broad.mit.edu	37	chr17	641234	641234	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	acttcctaagtcgaaaccgcCtcatgatcacacatcatgcg	6	14	3	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:641234C>G	uc002frp.2	+	3	396	c.355C>G	c.(355-357)CTC>GTC	p.L119V	FAM57A_uc002frq.2_Missense_Mutation_p.L119V|FAM57A_uc002frr.2_Missense_Mutation_p.L29V	NM_024792	NP_079068	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	119	TLC.|Helical; (Potential).					integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		TCGAAACCGCCTCATGATCAC	0.552													0	0	0	0.00499	0	17	91										G	641234	C	G	641234	3	3	2	1	0	0	0	0	1	0	0	0	5588	681	24	4	365	4	FAM57A	17	641234	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		641234	80553976	90	260										
ASPA	443	broad.mit.edu	37	chr17	3402335	3402335	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aagaagcttttgcaaagacaActaaactaacgctcaatgca	6	9	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:3402335A>T	uc010ckg.2	+	7	986	c.895A>T	c.(895-897)ACT>TCT	p.T299S	SPATA22_uc010vrg.1_Intron|ASPA_uc002fvq.2_Missense_Mutation_p.T299S	NM_001128085	NP_001121557	P45381	ACY2_HUMAN	aspartoacylase	299					aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TGCAAAGACAACTAAACTAAC	0.403													0	0	0	0.001168	0	5	35										T	3402335	A	T	3402335	3	4	2	1	0	0	0	0	1	0	0	0	1050	43	2	5	917	5	ASPA	17	3402335	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	2761101	3402335	77792875	91	261										
MYH4	4622	broad.mit.edu	37	chr17	10366440	10366440	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tttcttattggacaggatttGataaaatatgtggtagcttc	9	4	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:10366440G>C	uc002gmn.2	-	10	982	c.871C>G	c.(871-873)CAA>GAA	p.Q291E	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	291	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GACAGGATTTGATAAAATATG	0.373													0	0	0	0.012319	0	22	68										C	10366440	G	C	10366440	3	2	2	1	0	0	0	0	1	0	0	0	10037	1299	45	1	5072	1	MYH4	17	10366440	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	6964105	10366440	70828770	92	262										
NUFIP2	57532	broad.mit.edu	37	chr17	27613535	27613535	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caggttttgctgatctgtctGagagggcagatccacttgtg	13	8	2	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:27613535G>C	uc002hdy.3	-	2	1566	c.1477C>G	c.(1477-1479)CAG>GAG	p.Q493E	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	493						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			TGATCTGTCTGAGAGGGCAGA	0.438													0	0	0	0.013537	0	12	62										C	27613535	G	C	27613535	3	2	2	1	0	0	0	0	1	0	0	0	10749	1299	45	1	622	1	NUFIP2	17	27613535	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	17247095	27613535	53581675	93	263										
SYNRG	11276	broad.mit.edu	37	chr17	35913327	35913327	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atttcatgtcaaactgaacaGagagtgcatcttcagagtcc	8	9	4	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:35913327G>C	uc002hoa.2	-	14	2581	c.2498C>G	c.(2497-2499)TCT>TGT	p.S833C	SYNRG_uc010wde.1_Missense_Mutation_p.S755C|SYNRG_uc010wdf.1_Missense_Mutation_p.S755C|SYNRG_uc002hoc.2_Missense_Mutation_p.S754C|SYNRG_uc002hoe.2_Missense_Mutation_p.S755C|SYNRG_uc002hod.2_Missense_Mutation_p.S755C|SYNRG_uc010wdg.1_Missense_Mutation_p.S672C|SYNRG_uc002hob.2_Missense_Mutation_p.S833C|SYNRG_uc002hof.2_Missense_Mutation_p.S545C|SYNRG_uc010cvd.1_Missense_Mutation_p.S633C	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	833					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						AAACTGAACAGAGAGTGCATC	0.463													0	0	0	0.013537	0	12	72										C	35913327	G	C	35913327	3	2	2	1	0	0	0	0	1	0	0	0	15457	942	33	1	1555	1	SYNRG	17	35913327	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	8299792	35913327	45281883	94	264										
SC65	10609	broad.mit.edu	37	chr17	39967426	39967426	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tccgtgagggactcgtcggcGacgtccagcatcccctgata	12	14	0	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:39967426G>A	uc002hxt.2	-	2	857	c.573C>T	c.(571-573)GTC>GTT	p.V191V	FKBP10_uc002hxv.2_5'Flank|SC65_uc002hxu.2_Silent_p.V282V	NM_006455	NP_006446	Q92791	SC65_HUMAN	synaptonemal complex protein SC65	191					synaptonemal complex assembly	nucleolus|synaptonemal complex	binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.149)		ACTCGTCGGCGACGTCCAGCA	0.627													0	0	0	0.010771	0	38	227										A	39967426	G	A	39967426	2	1	2	1	0	0	0	0	0	0	0	1	13867	1045	37	1		1	SC65	17	39967426	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	4054099	39967426	41227784	95	265										
TTC25	83538	broad.mit.edu	37	chr17	40093047	40093047	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cagcagaagcctcagcccatGaaacacctcttacaccccac	5	18	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:40093047G>A	uc002hyj.3	+	5	581	c.492G>A	c.(490-492)ATG>ATA	p.M164I	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Missense_Mutation_p.M164I	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	164						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CTCAGCCCATGAAACACCTCT	0.552													0	0	0	0.013537	0	13	62										A	40093047	G	A	40093047	3	1	2	1	0	0	0	0	1	0	0	0	16690	1290	45	1	510	1	TTC25	17	40093047	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	125621	40093047	41102163	96	266										
EFTUD2	9343	broad.mit.edu	37	chr17	42937868	42937868	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ttgatcaacaccttcaatcaGaacccagttgccagcaggaa	7	12	3	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:42937868G>A	uc002ihn.2	-	17	1912	c.1651C>T	c.(1651-1653)CTG>TTG	p.L551L	EFTUD2_uc010wje.1_Silent_p.L516L|EFTUD2_uc010wjf.1_Silent_p.L541L	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	551						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				CCTTCAATCAGAACCCAGTTG	0.478													0	0	0	0.004007	0	16	89										A	42937868	G	A	42937868	2	1	2	1	0	0	0	0	0	0	0	1	4961	933	33	1		1	EFTUD2	17	42937868	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	2844821	42937868	38257342	97	267										
CBX4	8535	broad.mit.edu	37	chr17	77809510	77809510	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	catcagctgctcctgccgttCcctgggtgggagggaacaga	14	12	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:77809510C>T	uc002jxe.2	-	4	344	c.181G>A	c.(181-183)GAA>AAA	p.E61K		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	61	Chromo.|Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCCTGCCGTTCCCTGGGTGGG	0.637											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	10										T	77809510	C	T	77809510	3	4	2	1	0	0	0	0	1	0	0	0	2720	869	30	1	1509	1	CBX4	17	77809510	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	34871642	77809510	3385700	98	268										
B3GNTL1	146712	broad.mit.edu	37	chr17	81006556	81006556	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cctacaaaccttactggcatCattgaaaacagacagctcca	5	13	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr17:81006556C>T	uc002kgg.1	-	2	180	c.166G>A	c.(166-168)GAT>AAT	p.D56N	B3GNTL1_uc002kgf.1_5'UTR	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	56							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TTACTGGCATCATTGAAAACA	0.507													0	0	0	0.009535	0	30	102										T	81006556	C	T	81006556	3	4	2	1	0	0	0	0	1	0	0	0	1265	826	29	1	963	1	B3GNTL1	17	81006556	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	3197046	81006556	188654	99	269										
LAMA3	3909	broad.mit.edu	37	chr18	21492790	21492790	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gtttctccaaaggcccaactCaagagaaaatgggggtactg	11	9	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr18:21492790C>G	uc002kuq.2	+	56	7360	c.7274C>G	c.(7273-7275)TCA>TGA	p.S2425*	LAMA3_uc002kur.2_Nonsense_Mutation_p.S2369*|LAMA3_uc002kus.3_Nonsense_Mutation_p.S816*|LAMA3_uc002kut.3_Nonsense_Mutation_p.S760*	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2425	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGCCCAACTCAAGAGAAAAT	0.388													0	0	0	0.004007	0	16	87										G	21492790	C	G	21492790	4	3	2	1	0	0	0	0	0	1	0	0	8607	838	29	1	7671	1	LAMA3	18	21492790	Nonsense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		21492790	56584458	100	270										
KIAA1468	57614	broad.mit.edu	37	chr18	59855016	59855016	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ggagaccccggcccgattatCaattgatgcgatcgctgctc	11	13	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr18:59855016C>G	uc002lil.2	+	1	493	c.278C>G	c.(277-279)TCA>TGA	p.S93*	PIGN_uc002lii.3_5'Flank|PIGN_uc002lij.3_5'Flank|KIAA1468_uc002lik.1_Nonsense_Mutation_p.S93*|KIAA1468_uc010xel.1_Nonsense_Mutation_p.S93*	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	93							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GCCCGATTATCAATTGATGCG	0.672													0	0	0	0.009096	0	3	11										G	59855016	C	G	59855016	4	3	2	1	0	0	0	0	0	1	0	0	8236	838	29	1	280	1	KIAA1468	18	59855016	Nonsense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	38362226	59855016	18222232	101	271										
CD209	30835	broad.mit.edu	37	chr19	7810765	7810765	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tcacccactgcagccttcagCcgggtcagctcctggtagat	10	15	3	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:7810765C>A	uc002mht.2	-	4	454	c.387G>T	c.(385-387)CGG>CGT	p.R129R	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Silent_p.R105R|CD209_uc002mhr.2_Silent_p.R105R|CD209_uc002mhs.2_Silent_p.R105R|CD209_uc002mhu.2_Silent_p.R129R|CD209_uc010dvq.2_Silent_p.R129R|CD209_uc002mhq.2_Silent_p.R129R|CD209_uc002mhv.2_Silent_p.R105R|CD209_uc002mhx.2_Silent_p.R85R|CD209_uc002mhw.2_Silent_p.R85R|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	129	Extracellular (Probable).|2.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CAGCCTTCAGCCGGGTCAGCT	0.567													1	0	1.22674e-20	0.00874	1.3267e-20	40	164										A	7810765	C	A	7810765	2	1	2	1	0	0	0	0	0	0	0	1	2984	726	26	4		4	CD209	19	7810765	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		7810765	51318218	102	272										
ZBTB32	27033	broad.mit.edu	37	chr19	36206379	36206379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ccatagcacccccaccactgGagcctggcaggaggtctggc	12	16	1	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:36206379G>A	uc002oay.2	+	2	1061	c.851G>A	c.(850-852)GGA>GAA	p.G284E	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	284					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCACCACTGGAGCCTGGCAG	0.672													0	0	0	0.016522	0	22	100										A	36206379	G	A	36206379	3	1	2	1	0	0	0	0	1	0	0	0	17532	1174	41	1	853	1	ZBTB32	19	36206379	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	28395614	36206379	22922604	103	273										
C19orf54	284325	broad.mit.edu	37	chr19	41248515	41248515	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cacagctgatagtgccaactCttgccctgcttggacagcag	10	13	1	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:41248515C>T	uc002oou.1	-	6	999	c.879G>A	c.(877-879)AAG>AAA	p.K293K	C19orf54_uc002oow.1_Silent_p.K121K|C19orf54_uc002oox.1_RNA|C19orf54_uc002ooy.1_Intron|C19orf54_uc010xvs.1_RNA	NM_198476	NP_940878	Q5BKX5	CS054_HUMAN	hypothetical protein LOC284325	293											0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGTGCCAACTCTTGCCCTGCT	0.662													0	0	0	0.004672	0	3	26										T	41248515	C	T	41248515	2	4	2	1	0	0	0	0	0	0	0	1	1936	912	32	1		1	C19orf54	19	41248515	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	5042136	41248515	17880468	104	274										
SIGLEC8	27181	broad.mit.edu	37	chr19	51958721	51958721	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	agggaaatgtgctgggagccCtgagcgttctgagctcggca	16	9	1	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:51958721C>T	uc002pwt.2	-	4	1069	c.1002G>A	c.(1000-1002)CAG>CAA	p.Q334Q	SIGLEC8_uc010yda.1_Silent_p.Q225Q|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Silent_p.Q241Q	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	334	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCTGGGAGCCCTGAGCGTTCT	0.632													0	0	0	0.001168	0	5	42										T	51958721	C	T	51958721	2	4	2	1	0	0	0	0	0	0	0	1	14314	680	24	2		2	SIGLEC8	19	51958721	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	10710206	51958721	7170262	105	275										
ZNF613	79898	broad.mit.edu	37	chr19	52448817	52448817	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	atagcttatcacatacacgtGatctcatacaggataaagac	6	9	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:52448817G>T	uc002pxz.1	+	6	2104	c.1681G>T	c.(1681-1683)GAT>TAT	p.D561Y	ZNF613_uc002pya.1_Missense_Mutation_p.D525Y	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		ACATACACGTGATCTCATACA	0.428													1	0	2.56e-06	0.009096	2.72818e-06	4	44										T	52448817	G	T	52448817	3	4	2	1	0	0	0	0	1	0	0	0	18035	1290	45	3	1695	3	ZNF613	19	52448817	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	490096	52448817	6680166	106	276										
ZNF765	91661	broad.mit.edu	37	chr19	53912233	53912233	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	aatgagtgtggcaagaccttCagccggacgtcatcccttac	10	12	2	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:53912233C>T	uc010ydx.1	+	6	1752	c.1425C>T	c.(1423-1425)TTC>TTT	p.F475F	ZNF765_uc002qbm.2_Silent_p.F475F|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	475	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		GCAAGACCTTCAGCCGGACGT	0.378													0	0	0	0.013537	0	11	87										T	53912233	C	T	53912233	2	4	2	1	0	0	0	0	0	0	0	1	18136	825	29	1		1	ZNF765	19	53912233	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	1463416	53912233	5216750	107	277										
ZNF765	91661	broad.mit.edu	37	chr19	53912261	53912261	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cgtcatcccttacataccatCatagacttcatactggacag	5	13	3	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr19:53912261C>T	uc010ydx.1	+	6	1780	c.1453C>T	c.(1453-1455)CAT>TAT	p.H485Y	ZNF765_uc002qbm.2_Missense_Mutation_p.H485Y|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	485	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		TACATACCATCATAGACTTCA	0.373													0	0	0	0.00308	0	6	81										T	53912261	C	T	53912261	3	4	2	1	0	0	0	0	1	0	0	0	18136	826	29	1	1463	1	ZNF765	19	53912261	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	28	53912261	5216722	108	278										
PTPRA	5786	broad.mit.edu	37	chr20	3007825	3007825	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gaagagaatacagactatgtGaacgcatcctttattgatgt	9	6	0	4			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr20:3007825G>A	uc010zqd.1	+	18	2117	c.1800G>A	c.(1798-1800)GTG>GTA	p.V600V	PTPRA_uc002whj.2_Silent_p.V589V|PTPRA_uc002whk.2_Silent_p.V580V|PTPRA_uc002whl.2_Silent_p.V580V|PTPRA_uc002whm.2_Silent_p.V356V|PTPRA_uc002whn.2_Silent_p.V580V|PTPRA_uc002who.2_Silent_p.V252V	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	589	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						CAGACTATGTGAACGCATCCT	0.493													0	0	0	0.006122	0	19	136										A	3007825	G	A	3007825	2	1	2	1	0	0	0	0	0	0	0	1	12795	1277	45	1		1	PTPRA	20	3007825	Silent	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		3007825	60017695	109	279										
NINL	22981	broad.mit.edu	37	chr20	25481640	25481640	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	ggtgtggcagccgctctcctCtgggacctgcatgtcaggaa	14	12	3	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr20:25481640C>G	uc002wux.1	-	8	942	c.868G>C	c.(868-870)GAG>CAG	p.E290Q	NINL_uc010gdn.1_Missense_Mutation_p.E290Q|NINL_uc010gdo.1_Intron|NINL_uc010ztf.1_Missense_Mutation_p.E306Q	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	290					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CCGCTCTCCTCTGGGACCTGC	0.607													0	0	0	0.00308	0	6	17										G	25481640	C	G	25481640	3	3	2	1	0	0	0	0	1	0	0	0	10420	922	32	1	3348	1	NINL	20	25481640	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	22473815	25481640	37543880	110	280										
TPTE	7179	broad.mit.edu	37	chr21	10944672	10944672	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gtcttatgtttcatacctggGaatattcctaagcaacttaa	6	8	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr21:10944672G>A	uc002yip.1	-	11	930	c.562C>T	c.(562-564)CCC>TCC	p.P188S	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.P170S|TPTE_uc002yir.1_Missense_Mutation_p.P150S|TPTE_uc010gkv.1_Missense_Mutation_p.P50S	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	188					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCATACCTGGGAATATTCCTA	0.284													0	0	0	0.006214	0	9	173										A	10944672	G	A	10944672	3	1	2	1	0	0	0	0	1	0	0	0	16427	1174	41	1	1149	1	TPTE	21	10944672	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		10944672	37185223	111	281										
ATP5O	539	broad.mit.edu	37	chr21	35276300	35276300	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tcttgaggacagtttttaatTcagagagtgtggcttcttct	10	6	4	2			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr21:35276300T>A	uc002ytl.2	-	6	558	c.467A>T	c.(466-468)GAA>GTA	p.E156V	DONSON_uc002ysn.1_Intron	NM_001697	NP_001688	P48047	ATPO_HUMAN	mitochondrial ATP synthase, O subunit precursor	156					ATP catabolic process|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex|plasma membrane|proton-transporting ATP synthase complex, catalytic core F(1)	drug binding|hydrogen ion transporting ATP synthase activity, rotational mechanism			ovary(1)	1						AGTTTTTAATTCAGAGAGTGT	0.383													0	0	0	0.010729	0	11	57										A	35276300	T	A	35276300	3	1	2	1	0	0	0	0	1	0	0	0	1162	1783	62	5	182	5	ATP5O	21	35276300	Missense_Mutation	SNP	T	TCGA-BL-A13I-01A-11D-A13W-08	24331628	35276300	12853595	112	282										
RAB36	9609	broad.mit.edu	37	chr22	23501351	23501351	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	caagggccatttctcccagtCaggggccgcatgtgagcagg	14	12	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr22:23501351C>T	uc002zwv.1	+	9	768	c.728C>T	c.(727-729)TCA>TTA	p.S243L	RAB36_uc010gtw.1_Missense_Mutation_p.S221L	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	243					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		TTCTCCCAGTCAGGGGCCGCA	0.662													0	0	0	0.009096	0	3	10										T	23501351	C	T	23501351	3	4	2	1	0	0	0	0	1	0	0	0	12926	840	29	1	762	1	RAB36	22	23501351	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08		23501351	27803215	113	283										
PMM1	5372	broad.mit.edu	37	chr22	41980593	41980593	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gttctcggcaaacacataatCaaacttctcaatgacttcag	5	11	4	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chr22:41980593C>G	uc003bal.2	-	3	282	c.220G>C	c.(220-222)GAT>CAT	p.D74H		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	74					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						AACACATAATCAAACTTCTCA	0.547													0	0	0	0.008871	0	20	107										G	41980593	C	G	41980593	3	3	2	1	0	0	0	0	1	0	0	0	12136	826	29	1	592	1	PMM1	22	41980593	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	18479242	41980593	9323973	114	284										
VCX3B	425054	broad.mit.edu	37	chrX	8433508	8433508	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gaagatgagtccaaagccgaGagcctcgggacctccggcca	13	13	0	3			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chrX:8433508G>A	uc010ndo.2	+	2	324	c.17G>A	c.(16-18)AGA>AAA	p.R6K	VCX3B_uc011mht.1_Missense_Mutation_p.R6K|VCX3B_uc004csd.1_Missense_Mutation_p.R6K	NM_001001888	NP_001001888	Q9H321	VCX3B_HUMAN	variable charge, X-linked 3B	6						nucleolus					0						CCAAAGCCGAGAGCCTCGGGA	0.612													0	0	0	0.00632	0	25	67										A	8433508	G	A	8433508	3	1	2	1	0	0	0	0	1	0	0	0	17142	942	33	1	19	1	VCX3B	23	8433508	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08		8433508	146837052	115	285										
DDX3X	1654	broad.mit.edu	37	chrX	41204468	41204468	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgaagctgatcggatgttggAtatggggtttgagcctcaga	15	5	1	4			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chrX:41204468A>T	uc004dfe.2	+	11	1916	c.1061A>T	c.(1060-1062)GAT>GTT	p.D354V	DDX3X_uc004dff.2_Missense_Mutation_p.D354V|DDX3X_uc011mkq.1_Missense_Mutation_p.D338V|DDX3X_uc011mkr.1_Missense_Mutation_p.D354V|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	354	Necessary for interaction with XPO1.|Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						CGGATGTTGGATATGGGGTTT	0.403										HNSCC(61;0.18)			0	0	0	0.00623	0	39	176										T	41204468	A	T	41204468	3	4	2	1	0	0	0	0	1	0	0	0	4358	333	12	5	1103	5	DDX3X	23	41204468	Missense_Mutation	SNP	A	TCGA-BL-A13I-01A-11D-A13W-08	32770960	41204468	114066092	116	286										
TFE3	7030	broad.mit.edu	37	chrX	48895849	48895849	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	cacttgcgggccccggcggtGgggtgagggcctgggaagcc	20	12	0	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chrX:48895849G>A	uc004dmb.3	-	4	891	c.653C>T	c.(652-654)CCA>CTA	p.P218L	TFE3_uc004dmc.3_Missense_Mutation_p.P113L|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	218					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						CCCCGGCGGTGGGGTGAGGGC	0.706			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								0	0	0	0.014758	0	4	13										A	48895849	G	A	48895849	3	1	2	1	0	0	0	0	1	0	0	0	15797	1348	47	2	1102	2	TFE3	23	48895849	Missense_Mutation	SNP	G	TCGA-BL-A13I-01A-11D-A13W-08	7691381	48895849	106374711	117	287										
ZC3H12B	340554	broad.mit.edu	37	chrX	64708913	64708913	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	agatgcactccaagccacacCgccagctctgtcgatcaccc	7	18	2	1			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chrX:64708913C>T	uc010nko.2	+	1	208	c.199C>T	c.(199-201)CGC>TGC	p.R67C		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	67							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						CAAGCCACACCGCCAGCTCTG	0.488													0	0	0	0.001984	0	6	35										T	64708913	C	T	64708913	3	4	2	1	0	0	0	0	1	0	0	0	17559	652	23	2	234	2	ZC3H12B	23	64708913	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	15813064	64708913	90561647	118	288										
YIPF6	286451	broad.mit.edu	37	chrX	67741303	67741303	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	tgtctggtttggtgcagttaCcatcaccctcaactcaaaac	7	12	4	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chrX:67741303C>T	uc004dwy.2	+	5	421	c.398C>T	c.(397-399)ACC>ATC	p.T133I	YIPF6_uc011mph.1_Missense_Mutation_p.T90I	NM_173834	NP_776195	Q96EC8	YIPF6_HUMAN	Yip1 domain family, member 6	133	Helical; (Potential).					endoplasmic reticulum|integral to membrane					0						GGTGCAGTTACCATCACCCTC	0.403													0	0	0	0.00499	0	16	70										T	67741303	C	T	67741303	3	4	2	1	0	0	0	0	1	0	0	0	17479	507	18	2	416	2	YIPF6	23	67741303	Missense_Mutation	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	3032390	67741303	87529257	119	289										
FAM127A	8933	broad.mit.edu	37	chrX	134166743	134166743	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.383333333333333	46	2.99886258207388e-13	3.09951442445016	4.63738091637683	2.16580976863753	0.302239545907669	0.497356214784772	31	gtctttggatgggaggaggaCgaggacttctaggccgggag	19	6	2	0			TCGA-BL-A13I-01A-11D-A13W-08	TCGA-BL-A13I-11A-11D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aa490522-7bb9-4f82-8f19-eaf63f719bfe	5e1e29aa-bf11-4297-9681-e883ca7558d3	g.chrX:134166743C>T	uc004eyd.2	+	1	411	c.330C>T	c.(328-330)GAC>GAT	p.D110D	uc004eye.1_RNA	NM_001078171	NP_001071639	A6ZKI3	F127A_HUMAN	family with sequence similarity 127, member A	110											0	Acute lymphoblastic leukemia(192;0.000127)					GGGAGGAGGACGAGGACTTCT	0.657													0	0	0	0.004482	0	8	30										T	134166743	C	T	134166743	2	4	2	1	0	0	0	0	0	0	0	1	5431	535	19	2		2	FAM127A	23	134166743	Silent	SNP	C	TCGA-BL-A13I-01A-11D-A13W-08	66425440	134166743	21103817	120	290										
PLEKHG5	57449	broad.mit.edu	37	chr1	6528318	6528318	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cagctggacaggggtgcggcGgcggagacggggcgagggtg	24	8	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:6528318G>A	uc001ano.1	-	21	2847	c.2746C>T	c.(2746-2748)CGC>TGC	p.R916C	PLEKHG5_uc001ann.1_Missense_Mutation_p.R897C|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Missense_Mutation_p.R937C|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Missense_Mutation_p.R421C|PLEKHG5_uc009vma.1_Missense_Mutation_p.R700C|PLEKHG5_uc010nzr.1_Missense_Mutation_p.R929C|PLEKHG5_uc001ank.1_Missense_Mutation_p.R860C|PLEKHG5_uc009vmb.1_Missense_Mutation_p.R860C|PLEKHG5_uc001anl.1_Missense_Mutation_p.R860C|PLEKHG5_uc001anm.1_Missense_Mutation_p.R860C|PLEKHG5_uc001anr.1_Missense_Mutation_p.R123C	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	916					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GGGGTGCGGCGGCGGAGACGG	0.677													0	0	0	0.021553	0	5	10										A	6528318	G	A	6528318	3	1	3	1	0	0	0	0	1	0	0	0	12073	1116	39	2	450	2	PLEKHG5	1	6528318	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		6528318	242722303	1	291										
MACF1	23499	broad.mit.edu	37	chr1	39913530	39913530	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgtccagcgatctattgaaaGagggcgatcactagatgatg	12	7	2	4			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:39913530G>C	uc010oiu.1	+	47	15388	c.15257G>C	c.(15256-15258)AGA>ACA	p.R5086T	MACF1_uc010ois.1_Missense_Mutation_p.R4584T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6652	Spectrin 15.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTATTGAAAGAGGGCGATCA	0.448													0	0	0	0.024245	0	15	46										C	39913530	G	C	39913530	3	2	3	1	0	0	0	0	1	0	0	0	9144	942	33	1	20212	1	MACF1	1	39913530	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	33385212	39913530	209337091	2	292										
LEPRE1	64175	broad.mit.edu	37	chr1	43215938	43215938	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gaagtaggactccatgatgcGccgcaccttctccgtcacgt	10	14	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:43215938G>A	uc001chv.2	-	11	1752	c.1639C>T	c.(1639-1641)CGC>TGC	p.R547C	LEPRE1_uc001chw.2_Missense_Mutation_p.R547C|LEPRE1_uc001chx.3_Missense_Mutation_p.R547C	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	547					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCCATGATGCGCCGCACCTTC	0.582													0	0	0	0.038147	0	8	28										A	43215938	G	A	43215938	3	1	3	1	0	0	0	0	1	0	0	0	8729	1087	38	2	610	2	LEPRE1	1	43215938	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	3302408	43215938	206034683	3	293										
HYI	81888	broad.mit.edu	37	chr1	43917930	43917930	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tccagaaaaacggcctccatCtcagccttgactgctattcg	7	14	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:43917930C>G	uc001cjo.2	-	3	542	c.372G>C	c.(370-372)GAG>GAC	p.E124D	KIAA0467_uc001cjk.1_3'UTR|KIAA0467_uc001cjl.1_3'UTR|HYI_uc001cjm.2_Missense_Mutation_p.E51D|HYI_uc001cjn.2_Missense_Mutation_p.E124D|HYI_uc001cjp.2_Missense_Mutation_p.E51D	NM_031207	NP_112484	Q5T013	HYI_HUMAN	hydroxypyruvate isomerase homolog	124							hydroxypyruvate isomerase activity			ovary(1)	1	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CGGCCTCCATCTCAGCCTTGA	0.562													0	0	0	0.02938	0	7	27										G	43917930	C	G	43917930	3	3	3	1	0	0	0	0	1	0	0	0	7468	912	32	1	485	1	HYI	1	43917930	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	701992	43917930	205332691	4	294										
ZNF644	84146	broad.mit.edu	37	chr1	91406112	91406112	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctcattagtcataagaaattGaatgaactctttttggggat	8	5	3	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:91406112G>C	uc001dnw.2	-	3	941	c.799C>G	c.(799-801)CAA>GAA	p.Q267E	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.Q267E	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ATAAGAAATTGAATGAACTCT	0.348													0	0	0	0.034045	0	30	122										C	91406112	G	C	91406112	3	2	3	1	0	0	0	0	1	0	0	0	18057	1299	45	1	3200	1	ZNF644	1	91406112	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	47488182	91406112	157844509	5	295										
SPAG17	200162	broad.mit.edu	37	chr1	118628687	118628687	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atttgaactggatcaaaattCttttggtcctgatgaaaaag	8	5	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:118628687C>G	uc001ehk.2	-	13	1688	c.1620G>C	c.(1618-1620)AAG>AAC	p.K540N		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	540						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GATCAAAATTCTTTTGGTCCT	0.423													0	0	0	0.034045	0	27	60										G	118628687	C	G	118628687	3	3	3	1	0	0	0	0	1	0	0	0	14979	912	32	1	5195	1	SPAG17	1	118628687	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	27222575	118628687	130621934	6	296										
HIST2H2BF	440689	broad.mit.edu	37	chr1	149783666	149783666	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gcctctcccgcgatgcgctcGaagatgtcgttgacgaagga	13	12	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:149783666G>C	uc001esr.2	-	1	263	c.213C>G	c.(211-213)TTC>TTG	p.F71L	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.F71L|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.F71L	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	71					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					CGATGCGCTCGAAGATGTCGT	0.627													0	0	0	0.048971	0	41	262										C	149783666	G	C	149783666	3	2	3	1	0	0	0	0	1	0	0	0	7180	1049	37	1	588	1	HIST2H2BF	1	149783666	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	31154979	149783666	99466955	7	297										
FLG	2312	broad.mit.edu	37	chr1	152276103	152276103	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ccacgaatggtgtcctgaccCtcttgggacgctgagtgcct	12	13	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:152276103C>A	uc001ezu.1	-	3	11295	c.11259G>T	c.(11257-11259)GAG>GAT	p.E3753D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3753	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGACCCTCTTGGGACG	0.617									Ichthyosis				1	0	6.42063e-57	0.048971	7.49792e-57	121	722										A	152276103	C	A	152276103	3	1	3	1	0	0	0	0	1	0	0	0	5922	680	24	4	930	4	FLG	1	152276103	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	2492437	152276103	96974518	8	298										
ATP8B2	57198	broad.mit.edu	37	chr1	154321468	154321468	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tctggcaagaacatgcggctGagctctctcgcgctctccag	11	14	3	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:154321468G>T	uc001fex.2	+	28	3546	c.3546G>T	c.(3544-3546)CTG>CTT	p.L1182L		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	1168	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACATGCGGCTGAGCTCTCTCG	0.647													1	0	2.98393e-07	0.076483	3.14669e-07	24	101										T	154321468	G	T	154321468	2	4	3	1	0	0	0	0	0	0	0	1	1195	1277	45	3		3	ATP8B2	1	154321468	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	2045365	154321468	94929153	9	299										
OR10T2	128360	broad.mit.edu	37	chr1	158368889	158368889	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ggtgacaaattgctacatagCgatcatatcccatcacagca	7	11	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:158368889C>A	uc010pih.1	-	1	368	c.368G>T	c.(367-369)CGC>CTC	p.R123L		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TGCTACATAGCGATCATATCC	0.473													1	0	1.88708e-17	0.037714	2.1461e-17	28	445										A	158368889	C	A	158368889	3	1	3	1	0	0	0	0	1	0	0	0	10919	768	27	4	578	4	OR10T2	1	158368889	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	4047421	158368889	90881732	10	300										
RCSD1	92241	broad.mit.edu	37	chr1	167666699	167666699	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gccagcacccggcccaagagGaggtcccggaatcgccccag	13	17	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:167666699G>A	uc001gem.2	+	6	1025	c.838G>A	c.(838-840)GAG>AAG	p.E280K	RCSD1_uc010pli.1_Missense_Mutation_p.E250K	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	280	RCSD.									ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					GGCCCAAGAGGAGGTCCCGGA	0.612													0	0	0	0.069234	0	10	69										A	167666699	G	A	167666699	3	1	3	1	0	0	0	0	1	0	0	0	13185	1175	41	1	860	1	RCSD1	1	167666699	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	9297810	167666699	81583922	11	301										
RALGPS2	55103	broad.mit.edu	37	chr1	178753646	178753646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atgttcttaaggttacaccaGaagaatatgcggtaagcctc	9	8	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:178753646G>C	uc001glz.2	+	3	489	c.151G>C	c.(151-153)GAA>CAA	p.E51Q	RALGPS2_uc001gly.1_Missense_Mutation_p.E51Q|RALGPS2_uc010pnb.1_Missense_Mutation_p.E51Q	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	51	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						GGTTACACCAGAAGAATATGC	0.393													0	0	0	0.0333	0	17	77										C	178753646	G	C	178753646	3	2	3	1	0	0	0	0	1	0	0	0	13018	943	33	1	157	1	RALGPS2	1	178753646	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	11086947	178753646	70496975	12	302										
RNASEL	6041	broad.mit.edu	37	chr1	182555244	182555244	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tccctctttctcccctcacaTtgacatcagccccatggtcc	4	19	4	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:182555244T>C	uc001gpj.1	-	1	865	c.698A>G	c.(697-699)AAT>AGT	p.N233S	RNASEL_uc009wxz.1_Missense_Mutation_p.N233S|RNASEL_uc001gpk.2_Missense_Mutation_p.N233S|RNASEL_uc009wya.1_Missense_Mutation_p.N233S	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	233	2-5A binding (P-loop) 1.|ANK 6.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TCCCCTCACATTGACATCAGC	0.517									Hereditary_Prostate_Cancer				0	0	0	0.059317	0	36	136										C	182555244	T	C	182555244	3	2	3	1	0	0	0	0	1	0	0	0	13416	1493	52	5	1551	5	RNASEL	1	182555244	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	3801598	182555244	66695377	13	303										
NCF2	4688	broad.mit.edu	37	chr1	183532680	183532680	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctaccgtgtacttgtagtgcAccttgagtgtgtagggcatg	13	8	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:183532680A>T	uc001gqj.3	-	12	1342	c.1067T>A	c.(1066-1068)GTG>GAG	p.V356E	NCF2_uc010pod.1_Missense_Mutation_p.V311E|NCF2_uc010poe.1_Missense_Mutation_p.V275E|NCF2_uc001gqk.3_Missense_Mutation_p.V356E	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	356	OPR.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						CTTGTAGTGCACCTTGAGTGT	0.547													0	0	0	0.045515	0	45	384										T	183532680	A	T	183532680	3	4	3	1	0	0	0	0	1	0	0	0	10217	159	6	5	529	5	NCF2	1	183532680	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	977436	183532680	65717941	14	304										
HMCN1	83872	broad.mit.edu	37	chr1	186092199	186092199	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acattacatggcataaagatGggcgtgcaattgtggaatct	11	6	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:186092199G>A	uc001grq.1	+	81	12575	c.12346G>A	c.(12346-12348)GGG>AGG	p.G4116R		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4116	Ig-like C2-type 40.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCATAAAGATGGGCGTGCAAT	0.512													0	0	0	0.059317	0	27	166										A	186092199	G	A	186092199	3	1	3	1	0	0	0	0	1	0	0	0	7220	1348	47	2	12668	2	HMCN1	1	186092199	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	2559519	186092199	63158422	15	305										
KCNH1	3756	broad.mit.edu	37	chr1	211276926	211276926	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tcaatcgtgtctttatcagtCagctccccatacataaaact	4	12	4	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr1:211276926C>G	uc001hib.2	-	3	392	c.222G>C	c.(220-222)CTG>CTC	p.L74L	KCNH1_uc001hic.2_Silent_p.L74L	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	74	Cytoplasmic (Potential).|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTTTATCAGTCAGCTCCCCAT	0.279													0	0	0	0.0333	0	17	72										G	211276926	C	G	211276926	2	3	3	1	0	0	0	0	0	0	0	1	8031	813	29	1		1	KCNH1	1	211276926	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	25184727	211276926	37973695	16	306										
MRPL35	51318	broad.mit.edu	37	chr2	86434448	86434448	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gtggcctttgggtgaggagaAaggtgagtcttcacactgtt	15	6	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:86434448A>C	uc002srg.3	+	3	434	c.376A>C	c.(376-378)AAG>CAG	p.K126Q	MRPL35_uc002srf.3_Missense_Mutation_p.K126Q	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	126					translation	mitochondrial ribosome	structural constituent of ribosome				0						GGTGAGGAGAAAGGTGAGTCT	0.294													0	0	0	0.069288	0	20	56										C	86434448	A	C	86434448	3	2	3	1	0	0	0	0	1	0	0	0	9798	15	1	5	386	5	MRPL35	2	86434448	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08		86434448	156764925	17	307										
IMP4	92856	broad.mit.edu	37	chr2	131103630	131103630	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acctatttcccgtgcccaaaGatgacagccaccgggtcatc	8	15	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:131103630G>C	uc002tra.1	+	7	651	c.634G>C	c.(634-636)GAT>CAT	p.D212H		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	212	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					CGTGCCCAAAGATGACAGCCA	0.592													0	0	0	0.038395	0	18	89										C	131103630	G	C	131103630	3	2	3	1	0	0	0	0	1	0	0	0	7720	942	33	1	660	1	IMP4	2	131103630	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	44669182	131103630	112095743	18	308										
TMEM163	81615	broad.mit.edu	37	chr2	135308215	135308215	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acaatcgccgatgacaggacGtccaggatggcatcaaacta	10	11	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:135308215G>A	uc002ttx.2	-	4	450	c.384C>T	c.(382-384)GAC>GAT	p.D128D	TMEM163_uc002tty.2_RNA	NM_030923	NP_112185	Q8TC26	TM163_HUMAN	transmembrane protein 163	128	Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(221;0.154)		ATGACAGGACGTCCAGGATGG	0.502													0	0	0	0.080935	0	11	76										A	135308215	G	A	135308215	2	1	3	1	0	0	0	0	0	0	0	1	16075	1136	40	2		2	TMEM163	2	135308215	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	4204585	135308215	107891158	19	309										
NXPH2	11249	broad.mit.edu	37	chr2	139428760	139428761	+	Missense_Mutation	DNP	GT	GT	AA													0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tggattccttggtctccaagGtagactggggggaaacttca							TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:139428760_139428761GT>AA	uc002tvi.2	-	2	526_527	c.526_527AC>TT	c.(526-528)ACC>TTC	p.T176F		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	176	IV (linker domain).				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		GGTCTCCAAGGTAGACTGGGGG	0.47													0	0	0	0.004672	0	9	39										AA	139428761	GT	AA	139428760	3	1	3	1	0	0	0	0	1	0	0	0	10791	1261	44	2	271	2	NXPH2	2	139428760	Missense_Mutation	DNP	GT	TCGA-BL-A13J-01A-11D-A10S-08	4120545	139428760	103770613	20	310										
SCN3A	6328	broad.mit.edu	37	chr2	166003482	166003482	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgaagaactttccaacagctCtcctaacccacctattccac	3	16	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:166003482C>G	uc002ucx.2	-	12	1930	c.1438G>C	c.(1438-1440)GAG>CAG	p.E480Q	SCN3A_uc002ucy.2_Missense_Mutation_p.E480Q|SCN3A_uc002ucz.2_Missense_Mutation_p.E480Q|SCN3A_uc002uda.1_Missense_Mutation_p.E349Q|SCN3A_uc002udb.1_Missense_Mutation_p.E349Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	480						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TCCAACAGCTCTCCTAACCCA	0.443													0	0	0	0.059317	0	33	85										G	166003482	C	G	166003482	3	3	3	1	0	0	0	0	1	0	0	0	13918	922	32	1	4632	1	SCN3A	2	166003482	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	26574722	166003482	77195891	21	311										
TTN	7273	broad.mit.edu	37	chr2	179411904	179411904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cacccaaagaattgtattacGttctttcttctcaacccagt	4	12	3	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:179411904G>A	uc010zfg.1	-	289	86868	c.86644C>T	c.(86644-86646)CGT>TGT	p.R28882C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22577C|TTN_uc010zfi.1_Missense_Mutation_p.R22510C|TTN_uc010zfj.1_Missense_Mutation_p.R22385C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29809							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGTATTACGTTCTTTCTTC	0.423													0	0	0	0.048971	0	56	215										A	179411904	G	A	179411904	3	1	3	1	0	0	0	0	1	0	0	0	16732	1145	40	2	13723	2	TTN	2	179411904	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	13408422	179411904	63787469	22	312										
GTF3C3	9330	broad.mit.edu	37	chr2	197650253	197650253	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agactaggccctggtgttttGagaaagcttcatcaattatg	10	7	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr2:197650253G>C	uc002uts.2	-	7	1043	c.953C>G	c.(952-954)TCA>TGA	p.S318*	GTF3C3_uc010zgu.1_Nonsense_Mutation_p.S318*|GTF3C3_uc002utu.2_Nonsense_Mutation_p.S318*|GTF3C3_uc002utt.3_5'UTR	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	318	TPR 5.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						CTGGTGTTTTGAGAAAGCTTC	0.343													0	0	0	0.080935	0	11	48										C	197650253	G	C	197650253	4	2	3	1	0	0	0	0	0	1	0	0	6874	1294	45	1	1755	1	GTF3C3	2	197650253	Nonsense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	18238349	197650253	45549120	23	313										
MAPKAPK3	7867	broad.mit.edu	37	chr3	50684226	50684226	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cccacagagaggctgaccatCactcagttcatgaaccaccc	7	16	3	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr3:50684226C>A	uc003day.1	+	11	1481	c.885C>A	c.(883-885)ATC>ATA	p.I295I	MAPKAPK3_uc003daz.1_Silent_p.I295I|MAPKAPK3_uc003dba.1_Silent_p.I295I|MAPKAPK3_uc010hlr.1_Silent_p.I295I	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	295	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		GGCTGACCATCACTCAGTTCA	0.612													1	0	1.5739e-10	0.028581	1.71161e-10	14	70										A	50684226	C	A	50684226	2	1	3	1	0	0	0	0	0	0	0	1	9290	816	29	3		3	MAPKAPK3	3	50684226	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		50684226	147338204	24	314										
MAPKAPK3	7867	broad.mit.edu	37	chr3	50685381	50685381	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gactacgaccaggtgaagatCaaggacctgaagacctctaa	10	10	2	4			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr3:50685381C>T	uc003day.1	+	13	1649	c.1053C>T	c.(1051-1053)ATC>ATT	p.I351I	MAPKAPK3_uc003daz.1_Silent_p.I351I|MAPKAPK3_uc003dba.1_Silent_p.I351I|MAPKAPK3_uc010hlr.1_Silent_p.I351I	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	351					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		AGGTGAAGATCAAGGACCTGA	0.552													0	0	0	0.09836	0	42	147										T	50685381	C	T	50685381	2	4	3	1	0	0	0	0	0	0	0	1	9290	816	29	1		1	MAPKAPK3	3	50685381	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	1155	50685381	147337049	25	315										
SLMAP	7871	broad.mit.edu	37	chr3	57827025	57827025	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ttatttgtttgtttcaaccaGttacccatgggtgtattgtt	8	6	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr3:57827025G>A	uc003dje.1	+	3	552	c.347_splice	c.e3-1	p.V116_splice	SLMAP_uc003djc.1_Splice_Site_p.V116_splice|SLMAP_uc003djd.1_Splice_Site_p.V116_splice|SLMAP_uc003djf.1_Splice_Site_p.V116_splice	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein						muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GTTTCAACCAGTTACCCATGG	0.318													0	0	0	0.048971	0	51	20										A	57827025	G	A	57827025	5	1	3	1	0	0	0	0	0	0	1	0	14749	1043	36	2	356	2	SLMAP	3	57827025	Splice_Site	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	7141644	57827025	140195405	26	316										
CBLB	868	broad.mit.edu	37	chr3	105378062	105378062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tttagggggtctggctggtgCctgtgaaccatctgtgtaga	15	7	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr3:105378062C>T	uc003dwc.2	-	19	3023	c.2701G>A	c.(2701-2703)GCA>ACA	p.A901T	CBLB_uc003dwa.2_Missense_Mutation_p.A116T|CBLB_uc011bhi.1_Missense_Mutation_p.A879T	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	901	Pro-rich.|Interaction with SH3KBP1.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						CTGGCTGGTGCCTGTGAACCA	0.443			Mis S		AML								0	0	0	0.014758	0	4	74										T	105378062	C	T	105378062	3	4	3	1	0	0	0	0	1	0	0	0	2701	739	26	2	251	2	CBLB	3	105378062	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	47551037	105378062	92644368	27	317										
DNAJB11	51726	broad.mit.edu	37	chr3	186299223	186299223	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ggaagtgcaattgtcggcaaGagatgcggaccacccagctg	14	10	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr3:186299223G>C	uc003fqi.2	+	5	740	c.520G>C	c.(520-522)GAG>CAG	p.E174Q		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	174					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		TTGTCGGCAAGAGATGCGGAC	0.517													0	0	0	0.069456	0	31	139										C	186299223	G	C	186299223	3	2	3	1	0	0	0	0	1	0	0	0	4616	943	33	1	538	1	DNAJB11	3	186299223	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	80921161	186299223	11723207	28	318										
FAM193A	8603	broad.mit.edu	37	chr4	2692602	2692602	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aaataaagttgtcatggccaCgtcatcagccacgtcctctg	8	12	4	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:2692602C>T	uc010icl.2	+	13	2186	c.1835C>T	c.(1834-1836)ACG>ATG	p.T612M	FAM193A_uc010ick.2_Missense_Mutation_p.T812M|FAM193A_uc003gfd.2_Missense_Mutation_p.T612M|FAM193A_uc011bvm.1_Missense_Mutation_p.T634M|FAM193A_uc011bvn.1_Missense_Mutation_p.T612M|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.T466M	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	612										ovary(3)	3						GTCATGGCCACGTCATCAGCC	0.448													0	0	0	0.0333	0	15	92										T	2692602	C	T	2692602	3	4	3	1	0	0	0	0	1	0	0	0	5524	536	19	2	1877	2	FAM193A	4	2692602	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		2692602	188461674	29	319										
AFM	173	broad.mit.edu	37	chr4	74363404	74363404	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gagacaactgagaaaagcctCaagatggtacaacaagaatg	10	7	1	4			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:74363404C>G	uc003hhb.2	+	10	1258	c.1227C>G	c.(1225-1227)CTC>CTG	p.L409L		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	409	Albumin 3.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGAAAAGCCTCAAGATGGTAC	0.338													0	0	0	0.024245	0	13	29										G	74363404	C	G	74363404	2	3	3	1	0	0	0	0	0	0	0	1	361	813	29	1		1	AFM	4	74363404	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	71670802	74363404	116790872	30	320										
SEC31A	22872	broad.mit.edu	37	chr4	83776177	83776177	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ttcttcatcaccactgcagtGatgagcttgagaaacgaaaa	8	9	3	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:83776177G>A	uc003hnf.2	-	17	2051	c.1887C>T	c.(1885-1887)ATC>ATT	p.I629I	SEC31A_uc003hne.2_Silent_p.I362I|SEC31A_uc011ccl.1_Silent_p.I590I|SEC31A_uc003hnl.2_Silent_p.I590I|SEC31A_uc003hng.2_Silent_p.I629I|SEC31A_uc003hnh.2_Silent_p.I629I|SEC31A_uc003hni.2_Silent_p.I629I|SEC31A_uc003hnj.2_Silent_p.I590I|SEC31A_uc011ccm.1_Silent_p.I624I|SEC31A_uc011ccn.1_Silent_p.I629I|SEC31A_uc003hnk.2_Silent_p.I590I|SEC31A_uc003hnm.2_Silent_p.I629I|SEC31A_uc003hnn.1_Silent_p.I629I	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	629					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				CCACTGCAGTGATGAGCTTGA	0.348													0	0	0	0.02938	0	7	34										A	83776177	G	A	83776177	2	1	3	1	0	0	0	0	0	0	0	1	13998	1280	45	1		1	SEC31A	4	83776177	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	9412773	83776177	107378099	31	321										
MTTP	4547	broad.mit.edu	37	chr4	100532321	100532321	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aaaattgtccgtcgagttctGaaggaaatggtcgctcacaa	10	8	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:100532321G>C	uc003hvc.3	+	14	2047	c.1791G>C	c.(1789-1791)CTG>CTC	p.L597L	MTTP_uc011cej.1_Silent_p.L624L	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	597	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GTCGAGTTCTGAAGGAAATGG	0.393													0	0	0	0.0918	0	22	86										C	100532321	G	C	100532321	2	2	3	1	0	0	0	0	0	0	0	1	9964	1277	45	1		1	MTTP	4	100532321	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	16756144	100532321	90621955	32	322										
CENPE	1062	broad.mit.edu	37	chr4	104080302	104080302	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aagtccatatgaagggttttGaaattttggaattcttgatc	9	4	1	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:104080302G>C	uc003hxb.1	-	22	2556	c.2466C>G	c.(2464-2466)TTC>TTG	p.F822L	CENPE_uc003hxc.1_Missense_Mutation_p.F797L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	822	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GAAGGGTTTTGAAATTTTGGA	0.348													0	0	0	0.069234	0	11	71										C	104080302	G	C	104080302	3	2	3	1	0	0	0	0	1	0	0	0	3230	1281	45	1	5751	1	CENPE	4	104080302	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	3547981	104080302	87073974	33	323										
ANK2	287	broad.mit.edu	37	chr4	114290876	114290876	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cagagaggagagctctccgcGgaaaaccagcctcgtaatag	12	11	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:114290876G>A	uc003ibe.3	+	43	11625	c.11525G>A	c.(11524-11526)CGG>CAG	p.R3842Q	ANK2_uc003ibd.3_Missense_Mutation_p.R1748Q|ANK2_uc003ibf.3_Missense_Mutation_p.R1757Q|ANK2_uc011cgc.1_Missense_Mutation_p.R933Q|ANK2_uc003ibg.3_Missense_Mutation_p.R741Q|ANK2_uc003ibh.3_Missense_Mutation_p.R431Q|ANK2_uc011cgd.1_Missense_Mutation_p.R1144Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3809					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCTCTCCGCGGAAAACCAGC	0.532													0	0	0	0.080935	0	11	68										A	114290876	G	A	114290876	3	1	3	1	0	0	0	0	1	0	0	0	621	1116	39	2	11760	2	ANK2	4	114290876	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	10210574	114290876	76863400	34	324										
FAT4	79633	broad.mit.edu	37	chr4	126336800	126336800	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agacccctacctaccatttaActgttcaggcaacagatcga	6	13	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr4:126336800A>C	uc003ifj.3	+	5	6682	c.6682A>C	c.(6682-6684)ACT>CCT	p.T2228P	FAT4_uc011cgp.1_Missense_Mutation_p.T526P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2228	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTACCATTTAACTGTTCAGGC	0.438													0	0	0	0.099896	0	25	121										C	126336800	A	C	126336800	3	2	3	1	0	0	0	0	1	0	0	0	5692	43	2	5	6700	5	FAT4	4	126336800	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	12045924	126336800	64817476	35	325										
FASTKD3	79072	broad.mit.edu	37	chr5	7867809	7867809	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tcgttgtaaagctcctgctgCcatagtgtcaggcagggttt	12	9	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr5:7867809C>T	uc003jeb.2	-	2	525	c.388G>A	c.(388-390)GCA>ACA	p.A130T	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	130					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GCTCCTGCTGCCATAGTGTCA	0.418													0	0	0	0.020292	0	14	61										T	7867809	C	T	7867809	3	4	3	1	0	0	0	0	1	0	0	0	5687	739	26	2	1624	2	FASTKD3	5	7867809	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		7867809	173047451	36	326										
ELOVL7	79993	broad.mit.edu	37	chr5	60083198	60083198	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ttatcataaagatgcacagtCctcgatgtaagatcactgaa	7	8	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr5:60083198C>T	uc003jsi.3	-	3	227	c.27G>A	c.(25-27)AGG>AGA	p.R9R	ELOVL7_uc011cqo.1_5'UTR|ELOVL7_uc010iwk.2_Silent_p.R9R|ELOVL7_uc003jsj.3_5'UTR	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	9					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				GATGCACAGTCCTCGATGTAA	0.338													0	0	0	0.105934	0	11	59										T	60083198	C	T	60083198	2	4	3	1	0	0	0	0	0	0	0	1	5079	854	30	1		1	ELOVL7	5	60083198	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	52215389	60083198	120832062	37	327										
GPR98	84059	broad.mit.edu	37	chr5	89985850	89985850	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctaggggctttaacagaggcAgtcattattattgaggcctc	11	8	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr5:89985850A>T	uc003kju.2	+	30	6759	c.6663A>T	c.(6661-6663)GCA>GCT	p.A2221A	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2221	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAACAGAGGCAGTCATTATTA	0.378													0	0	0	0.021553	0	4	12										T	89985850	A	T	89985850	2	4	3	1	0	0	0	0	0	0	0	1	6721	175	7	5		5	GPR98	5	89985850	Silent	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	29902652	89985850	90929410	38	328										
TRIM36	55521	broad.mit.edu	37	chr5	114469698	114469698	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgttccacacacttctatctCattccatgacatttcatcat	2	13	4	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr5:114469698C>G	uc003kqs.2	-	8	1902	c.1393G>C	c.(1393-1395)GAG>CAG	p.E465Q	TRIM36_uc011cwc.1_Missense_Mutation_p.E453Q|TRIM36_uc003kqt.2_Missense_Mutation_p.E310Q	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	465	Fibronectin type-III.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		ACTTCTATCTCATTCCATGAC	0.363													0	0	0	0.020292	0	14	62										G	114469698	C	G	114469698	3	3	3	1	0	0	0	0	1	0	0	0	16507	835	29	1	805	1	TRIM36	5	114469698	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	24483848	114469698	66445562	39	329										
PCDHA1	56147	broad.mit.edu	37	chr5	140167231	140167231	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gccgacgtgaatgacaacgcGcctgcgttcgcgcagcccga	13	15	0	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr5:140167231G>A	uc003lhb.2	+	1	1356	c.1356G>A	c.(1354-1356)GCG>GCA	p.A452A	PCDHA1_uc003lha.2_Silent_p.A452A|PCDHA1_uc003lgz.2_Silent_p.A452A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAACGCGCCTGCGTTCG	0.682													0	0	0	0.104719	0	40	147										A	140167231	G	A	140167231	2	1	3	1	0	0	0	0	0	0	0	1	11519	1074	38	2		2	PCDHA1	5	140167231	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	25697533	140167231	40748029	40	330										
HLA-A	3105	broad.mit.edu	37	chr6	29911314	29911314	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acgggaaggagacgctgcagCgcacgggtaccaggggccac	17	12	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr6:29911314C>T	uc003nol.2	+	3	613	c.613C>T	c.(613-615)CGC>TGC	p.R205C	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc010jrq.2_Missense_Mutation_p.R84C|HLA-A_uc003nok.2_Missense_Mutation_p.R84C|HLA-A_uc003non.2_Missense_Mutation_p.R205C|HLA-A_uc003noo.2_Missense_Mutation_p.R205C|HLA-A_uc010jrr.2_Missense_Mutation_p.R205C|HLA-A_uc003nom.2_Missense_Mutation_p.R84C|HLA-A_uc010klp.2_Missense_Mutation_p.R177C|HLA-A_uc011dmc.1_Missense_Mutation_p.R84C|HLA-A_uc011dmd.1_Missense_Mutation_p.R84C	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	205	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GACGCTGCAGCGCACGGGTAC	0.652									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			0	0	0	0.047766	0	8	80										T	29911314	C	T	29911314	3	4	3	1	0	0	0	0	1	0	0	0	7195	768	27	2	623	2	HLA-A	6	29911314	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		29911314	141203753	41	331										
FKBP5	2289	broad.mit.edu	37	chr6	35554818	35554818	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gggactcacacaccttgaagTatacggttcccttctctttg	8	12	2	1	rs61753297		TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr6:35554818T>C	uc011dte.1	-	8	1036	c.833A>G	c.(832-834)TAC>TGC	p.Y278C	FKBP5_uc003okx.2_Missense_Mutation_p.Y278C|FKBP5_uc011dtf.1_Missense_Mutation_p.Y99C|FKBP5_uc003oky.2_Missense_Mutation_p.Y278C|FKBP5_uc003okz.2_Missense_Mutation_p.T248A	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	278	TPR 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						CACCTTGAAGTATACGGTTCC	0.408													0	0	0	0.048971	0	95	91										C	35554818	T	C	35554818	3	2	3	1	0	0	0	0	1	0	0	0	5911	1638	57	5	614	5	FKBP5	6	35554818	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	5643504	35554818	135560249	42	332										
POPDC3	64208	broad.mit.edu	37	chr6	105609536	105609536	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atgaagcagatgacaaacagTacaaaattccaggaaaatat	7	6	0	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr6:105609536T>C	uc003prb.2	-	2	651	c.249A>G	c.(247-249)GTA>GTG	p.V83V	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	83	Helical; (Potential).					integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TGACAAACAGTACAAAATTCC	0.433													0	0	0	0.048971	0	90	100										C	105609536	T	C	105609536	2	2	3	1	0	0	0	0	0	0	0	1	12256	1625	57	5		5	POPDC3	6	105609536	Silent	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	70054718	105609536	65505531	43	333										
T	6862	broad.mit.edu	37	chr6	166571980	166571980	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gtgtagtgcgcgggggagccCcggaagaactgggcccccag	18	12	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr6:166571980C>A	uc003quu.1	-	9	1624	c.1131G>T	c.(1129-1131)CGG>CGT	p.R377R	T_uc003qut.1_Silent_p.R378R|T_uc003quv.1_Silent_p.R319R	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	377					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		CGGGGGAGCCCCGGAAGAACT	0.706									Chordoma_Familial_Clustering_of				1	0	3.32936e-07	0.038395	3.48981e-07	16	51										A	166571980	C	A	166571980	2	1	3	1	0	0	0	0	0	0	0	1	15485	610	22	4		4	T	6	166571980	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	60962444	166571980	4543087	44	334										
FERD3L	222894	broad.mit.edu	37	chr7	19184975	19184975	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgtccacgcagctctccggaTaggccgccatcgcttcggct	11	16	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:19184975T>C	uc003suo.1	-	1	70	c.11A>G	c.(10-12)TAT>TGT	p.Y4C	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	4					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						GCTCTCCGGATAGGCCGCCAT	0.642													0	0	0	0.09319	0	11	60										C	19184975	T	C	19184975	3	2	3	1	0	0	0	0	1	0	0	0	5816	1406	49	5	493	5	FERD3L	7	19184975	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08		19184975	139953688	45	335										
PDE1C	5137	broad.mit.edu	37	chr7	31862705	31862705	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acctttgggtaccttggcccTccatctctcccgattgatgt	8	14	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:31862705T>C	uc003tcm.1	-	14	2033	c.1564A>G	c.(1564-1566)AGG>GGG	p.R522G	PDE1C_uc003tcn.1_Missense_Mutation_p.R522G|PDE1C_uc003tco.1_Missense_Mutation_p.R582G|PDE1C_uc003tcr.2_Missense_Mutation_p.R522G|PDE1C_uc003tcs.2_Missense_Mutation_p.R522G	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	522					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			ACCTTGGCCCTCCATCTCTCC	0.458													0	0	0	0.074837	0	35	170										C	31862705	T	C	31862705	3	2	3	1	0	0	0	0	1	0	0	0	11635	1550	54	5	356	5	PDE1C	7	31862705	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	12677730	31862705	127275958	46	336										
SFRP4	6424	broad.mit.edu	37	chr7	37955842	37955842	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gtcgcgcgcgcgttggcacaCcgacttgcacggcttgatag	14	13	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:37955842C>A	uc003tfo.3	-	1	684	c.298G>T	c.(298-300)GTG>TTG	p.V100L		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	100	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						CGTTGGCACACCGACTTGCAC	0.627													1	0	5.03518e-11	0.043863	5.54508e-11	17	60										A	37955842	C	A	37955842	3	1	3	1	0	0	0	0	1	0	0	0	14163	507	18	4	766	4	SFRP4	7	37955842	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	6093137	37955842	121182821	47	337										
C7orf36	57002	broad.mit.edu	37	chr7	39612174	39612174	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ggatagattgttcatatgtaGaatgttgtagaacacaggag	12	3	1	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:39612174G>C	uc003thc.3	+	3	559	c.550G>C	c.(550-552)GAA>CAA	p.E184Q		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	184											0						TTCATATGTAGAATGTTGTAG	0.393													0	0	0	0.049695	0	20	92										C	39612174	G	C	39612174	3	2	3	1	0	0	0	0	1	0	0	0	2390	943	33	1	560	1	C7orf36	7	39612174	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	1656332	39612174	119526489	48	338										
GRM8	2918	broad.mit.edu	37	chr7	126544099	126544099	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tcttgctgatagacaggtgcTattttggatccccaactatc	8	10	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:126544099T>A	uc003vlr.2	-	4	1256	c.945A>T	c.(943-945)ATA>ATT	p.I315I	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.I315I|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Silent_p.I36I	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	315	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	AGACAGGTGCTATTTTGGATC	0.403										HNSCC(24;0.065)			0	0	0	0.059317	0	35	121										A	126544099	T	A	126544099	2	1	3	1	0	0	0	0	0	0	0	1	6803	1512	53	5		5	GRM8	7	126544099	Silent	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	86931925	126544099	32594564	49	339										
LRGUK	136332	broad.mit.edu	37	chr7	133812300	133812300	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tctaacatagcctcctcctaCctgctccagcagctcatgca	5	17	2	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:133812300C>A	uc003vrm.1	+	1	196	c.180C>A	c.(178-180)TAC>TAA	p.Y60*		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	60							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						CCTCCTCCTACCTGCTCCAGC	0.597													1	0	1.17739e-12	0.108266	1.32172e-12	26	154										A	133812300	C	A	133812300	4	1	3	1	0	0	0	0	0	1	0	0	8943	518	18	4	182	4	LRGUK	7	133812300	Nonsense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	7268201	133812300	25326363	50	340										
ARHGEF5	7984	broad.mit.edu	37	chr7	144062382	144062382	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gaggacatatgaactcagggGgtcatgccaaaacaagacct	11	9	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr7:144062382G>A	uc003wel.2	+	2	2738	c.2620G>A	c.(2620-2622)GGT>AGT	p.G874S	ARHGEF5_uc003wek.2_Missense_Mutation_p.G874S|ARHGEF5_uc003wem.2_5'Flank	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	874					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					GAACTCAGGGGGTCATGCCAA	0.612													0	0	0	0.048971	0	74	140										A	144062382	G	A	144062382	3	1	3	1	0	0	0	0	1	0	0	0	909	1232	43	2	2622	2	ARHGEF5	7	144062382	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	10250082	144062382	15076281	51	341										
MCPH1	79648	broad.mit.edu	37	chr8	6357451	6357451	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	accacttccctgcagctcccGtaagtcagatgttgttttac	7	13	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr8:6357451G>A	uc003wqi.2	+	12	2282	c.2214_splice	c.e12+1	p.P738_splice	ANGPT2_uc003wqj.3_3'UTR|ANGPT2_uc003wqk.3_3'UTR|ANGPT2_uc010lri.2_3'UTR	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin							microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		TGCAGCTCCCGTAAGTCAGAT	0.428													0	0	0	0.020292	0	15	50										A	6357451	G	A	6357451	5	1	3	1	0	0	0	0	0	0	1	0	9398	1159	40	2	2269	2	MCPH1	8	6357451	Splice_Site	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		6357451	140006571	52	342										
KCNU1	157855	broad.mit.edu	37	chr8	36793051	36793051	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aggtttgtgatcacccggccAgccaatgagttcaagctgct	11	11	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr8:36793051A>T	uc010lvw.2	+	27	3150	c.3063A>T	c.(3061-3063)CCA>CCT	p.P1021P		NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1021	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCACCCGGCCAGCCAATGAGT	0.458													0	0	0	0.048971	0	71	103										T	36793051	A	T	36793051	2	4	3	1	0	0	0	0	0	0	0	1	8093	175	7	5		5	KCNU1	8	36793051	Silent	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	30435600	36793051	109570971	53	343										
POP1	10940	broad.mit.edu	37	chr8	99168597	99168597	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tcacagaccaggaggccagtGaaaaccatgttgctgccaca	10	12	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr8:99168597G>A	uc003yij.3	+	15	2477	c.2377G>A	c.(2377-2379)GAA>AAA	p.E793K	POP1_uc011lgv.1_Missense_Mutation_p.E793K|POP1_uc003yik.2_Missense_Mutation_p.E793K	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	793					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GGAGGCCAGTGAAAACCATGT	0.512													0	0	0	0.069456	0	35	216										A	99168597	G	A	99168597	3	1	3	1	0	0	0	0	1	0	0	0	12251	1291	45	1	2431	1	POP1	8	99168597	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	62375546	99168597	47195425	54	344										
ALDOB	229	broad.mit.edu	37	chr9	104192127	104192127	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tagagggtctcgtggaaaagGatcacacccccgatgctctg	12	11	3	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr9:104192127G>A	uc004bbk.2	-	3	316	c.234C>T	c.(232-234)ATC>ATT	p.I78I		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	78					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CGTGGAAAAGGATCACACCCC	0.517													0	0	0	0.048971	0	151	95										A	104192127	G	A	104192127	2	1	3	1	0	0	0	0	0	0	0	1	508	1164	41	1		1	ALDOB	9	104192127	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		104192127	37021304	55	345										
CUBN	8029	broad.mit.edu	37	chr10	17142151	17142151	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tccaagttgaaaagcagaagAggaatctccatcataaacct	7	9	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr10:17142151A>G	uc001ioo.2	-	14	1670	c.1618T>C	c.(1618-1620)TCT>CCT	p.S540P		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	540	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAAGCAGAAGAGGAATCTCCA	0.408													0	0	0	0.028581	0	17	104										G	17142151	A	G	17142151	3	3	3	1	0	0	0	0	1	0	0	0	4051	304	11	5	9469	5	CUBN	10	17142151	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08		17142151	118392596	56	346										
SVIL	6840	broad.mit.edu	37	chr10	29777621	29777621	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acgctccgcaggctgacgttGctgaagttttctttactggc	11	11	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr10:29777621G>A	uc001iut.1	-	23	5010	c.4257C>T	c.(4255-4257)AGC>AGT	p.S1419S	SVIL_uc010qdw.1_Silent_p.S333S|SVIL_uc001iuu.1_Silent_p.S993S|SVIL_uc009xlc.2_Silent_p.S211S	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1419	Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				GGCTGACGTTGCTGAAGTTTT	0.507													0	0	0	0.080935	0	10	35										A	29777621	G	A	29777621	2	1	3	1	0	0	0	0	0	0	0	1	15418	1310	46	2		2	SVIL	10	29777621	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	12635470	29777621	105757126	57	347										
TACC2	10579	broad.mit.edu	37	chr10	123843281	123843281	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gcacatccagcttcaagcctCgcttcattcccagctgctca	6	17	3	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr10:123843281C>T	uc001lfv.2	+	4	1626	c.1266C>T	c.(1264-1266)CTC>CTT	p.L422L	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.L422L|TACC2_uc010qtv.1_Silent_p.L422L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	422						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTTCAAGCCTCGCTTCATTCC	0.557													0	0	0	0.048971	0	42	109										T	123843281	C	T	123843281	2	4	3	1	0	0	0	0	0	0	0	1	15499	871	31	1		1	TACC2	10	123843281	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	94065660	123843281	11691466	58	348										
SLC25A22	79751	broad.mit.edu	37	chr11	792032	792032	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gcgcggcagtaggcgcccttCaggaaggccgaggggccctc	17	14	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:792032C>T	uc001lri.2	-	10	1197	c.855G>A	c.(853-855)CTG>CTA	p.L285L	CEND1_uc001lrh.1_5'Flank|SLC25A22_uc009yci.2_Silent_p.L285L|SLC25A22_uc001lrj.2_Silent_p.L285L	NM_024698	NP_078974	Q9H936	GHC1_HUMAN	mitochondrial glutamate carrier 1	285	Solcar 3.					integral to membrane|mitochondrial inner membrane|nucleus	L-glutamate transmembrane transporter activity|protein binding|symporter activity				0		all_cancers(49;4.75e-06)|all_epithelial(84;0.00204)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	L-Glutamic Acid(DB00142)	AGGCGCCCTTCAGGAAGGCCG	0.697													0	0	0	0.02938	0	5	13										T	792032	C	T	792032	2	4	3	1	0	0	0	0	0	0	0	1	14485	813	29	1		1	SLC25A22	11	792032	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		792032	134214484	59	349										
TRPM5	29850	broad.mit.edu	37	chr11	2439011	2439011	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctcctcggagccctcctgctCgaagtcatacacggtgagca	10	15	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:2439011C>G	uc001lwm.3	-	7	964	c.955G>C	c.(955-957)GAG>CAG	p.E319Q	TRPM5_uc010qxl.1_Missense_Mutation_p.E319Q|TRPM5_uc009ydn.2_Missense_Mutation_p.E321Q	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	319	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCCTCCTGCTCGAAGTCATAC	0.662													0	0	0	0.02938	0	5	18										G	2439011	C	G	2439011	3	3	3	1	0	0	0	0	1	0	0	0	16586	893	31	1	2614	1	TRPM5	11	2439011	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	1646979	2439011	132567505	60	350										
DCHS1	8642	broad.mit.edu	37	chr11	6662141	6662141	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ccagcagggcctgggccctcCgggggggtgaaccaccatca	15	15	1	1	rs143767864	byFrequency	TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:6662141C>T	uc001mem.1	-	2	1114	c.704G>A	c.(703-705)CGG>CAG	p.R235Q		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	235	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGCCCTCCGGGGGGGTGA	0.587													0	0	0	0.048971	0	45	110										T	6662141	C	T	6662141	3	4	3	1	0	0	0	0	1	0	0	0	4287	652	23	2	9272	2	DCHS1	11	6662141	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	4223130	6662141	128344375	61	351										
OR4C6	219432	broad.mit.edu	37	chr11	55433539	55433539	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aaaagtgccatgaagaaactCtggatgaaatgggaggcttt	12	5	1	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:55433539C>T	uc001nht.3	+	3	1162	c.897C>T	c.(895-897)CTC>CTT	p.L299L	OR4C6_uc010rik.1_Silent_p.L299L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGAAGAAACTCTGGATGAAAT	0.423													0	0	0	0.037714	0	29	55										T	55433539	C	T	55433539	2	4	3	1	0	0	0	0	0	0	0	1	11052	900	32	1		1	OR4C6	11	55433539	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	48771398	55433539	79572977	62	352										
OR5B21	219968	broad.mit.edu	37	chr11	58275356	58275356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agccaccgttttgggggctaCagctgatgagtaacccaagt	12	10	0	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:58275356C>T	uc010rki.1	-	1	223	c.223G>A	c.(223-225)GTA>ATA	p.V75I		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTGGGGGCTACAGCTGATGAG	0.512													0	0	0	0.024245	0	15	71										T	58275356	C	T	58275356	3	4	3	1	0	0	0	0	1	0	0	0	11151	478	17	2	708	2	OR5B21	11	58275356	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	2841817	58275356	76731160	63	353										
AHNAK	79026	broad.mit.edu	37	chr11	62288867	62288867	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aaatctcaatgtcagccttaGgaagggtaacatccacatct	7	10	3	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:62288867G>A	uc001ntl.2	-	5	13322	c.13022C>T	c.(13021-13023)CCT>CTT	p.P4341L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4341					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GTCAGCCTTAGGAAGGGTAAC	0.502													0	0	0	0.069234	0	10	388										A	62288867	G	A	62288867	3	1	3	1	0	0	0	0	1	0	0	0	414	1000	35	2	4770	2	AHNAK	11	62288867	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	4013511	62288867	72717649	64	354										
AHNAK	79026	broad.mit.edu	37	chr11	62289475	62289475	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cccttcatctttggacctttCagattcaggtcaacttcagg	7	12	6	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:62289475C>G	uc001ntl.2	-	5	12714	c.12414G>C	c.(12412-12414)CTG>CTC	p.L4138L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4138					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTGGACCTTTCAGATTCAGGT	0.517													0	0	0	0.045515	0	45	329										G	62289475	C	G	62289475	2	3	3	1	0	0	0	0	0	0	0	1	414	813	29	1		1	AHNAK	11	62289475	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	608	62289475	72717041	65	355										
SAPS3	55291	broad.mit.edu	37	chr11	68331848	68331848	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aaacaagagtgttctagaagCcatcagaggaagacttggat	11	6	2	4			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:68331848C>A	uc001onw.2	+	9	1190	c.923C>A	c.(922-924)GCC>GAC	p.A308D	SAPS3_uc001onv.2_Missense_Mutation_p.A308D|SAPS3_uc001ony.3_Missense_Mutation_p.A308D|SAPS3_uc001onx.2_Missense_Mutation_p.A308D|SAPS3_uc009ysh.2_Missense_Mutation_p.A308D|SAPS3_uc001onu.2_Missense_Mutation_p.A308D|SAPS3_uc010rqc.1_Intron|SAPS3_uc010rqd.1_Missense_Mutation_p.A15D	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	308					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			GTTCTAGAAGCCATCAGAGGA	0.458													1	0	1.08611e-07	0.080935	1.15233e-07	9	240										A	68331848	C	A	68331848	3	1	3	1	0	0	0	0	1	0	0	0	13838	739	26	4	949	4	SAPS3	11	68331848	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	6042373	68331848	66674668	66	356										
PPFIA1	8500	broad.mit.edu	37	chr11	70172733	70172733	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atggttctttaagccacgagGaagaccttgctaaagtaatt	9	7	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:70172733G>C	uc001opo.2	+	7	937	c.739G>C	c.(739-741)GAA>CAA	p.E247Q	PPFIA1_uc001opn.1_Missense_Mutation_p.E247Q|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	247					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AAGCCACGAGGAAGACCTTGC	0.398													0	0	0	0.048971	0	291	384										C	70172733	G	C	70172733	3	2	3	1	0	0	0	0	1	0	0	0	12309	1175	41	1	761	1	PPFIA1	11	70172733	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	1840885	70172733	64833783	67	357										
DSCAML1	57453	broad.mit.edu	37	chr11	117321323	117321323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acttgcggatcaccccgttgGgcttggtaggggggagccaa	16	10	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr11:117321323G>A	uc001prh.1	-	20	3832	c.3830C>T	c.(3829-3831)CCC>CTC	p.P1277L		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1217	Extracellular (Potential).|Fibronectin type-III 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACCCCGTTGGGCTTGGTAGG	0.582													0	0	0	0.024245	0	16	114										A	117321323	G	A	117321323	3	1	3	1	0	0	0	0	1	0	0	0	4769	1232	43	2	2567	2	DSCAML1	11	117321323	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	47148590	117321323	17685193	68	358										
DYRK4	8798	broad.mit.edu	37	chr12	4708904	4708904	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gctataccaaaagggccaagCctctgttaaagtcattgact	8	10	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:4708904C>G	uc001qmx.2	+	8	891	c.731C>G	c.(730-732)GCC>GGC	p.A244G	DYRK4_uc009zeh.1_Missense_Mutation_p.A359G|DYRK4_uc001qmy.1_Missense_Mutation_p.A244G	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	244	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			AAGGGCCAAGCCTCTGTTAAA	0.383													0	0	0	0.038395	0	18	80										G	4708904	C	G	4708904	3	3	3	1	0	0	0	0	1	0	0	0	4858	739	26	4	753	4	DYRK4	12	4708904	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		4708904	129142991	69	359										
ANO6	196527	broad.mit.edu	37	chr12	45810576	45810576	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atattggaaataagagtggaCgcatggaaactgaccaccca	10	8	0	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:45810576C>T	uc001roo.2	+	17	2441	c.2106C>T	c.(2104-2106)GAC>GAT	p.D702D	ANO6_uc010sld.1_Silent_p.D702D|ANO6_uc010sle.1_Silent_p.D702D|ANO6_uc010slf.1_Silent_p.D723D|ANO6_uc010slg.1_Silent_p.D684D	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	702	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						TAAGAGTGGACGCATGGAAAC	0.483													0	0	0	0.020292	0	14	61										T	45810576	C	T	45810576	2	4	3	1	0	0	0	0	0	0	0	1	701	535	19	2		2	ANO6	12	45810576	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	41101672	45810576	88041319	70	360										
SLC38A2	54407	broad.mit.edu	37	chr12	46764360	46764360	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aggattccactgcccacaatCgcattgctcagattaaatac	6	12	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:46764360C>G	uc001rpg.2	-	4	689	c.249G>C	c.(247-249)GCG>GCC	p.A83A	SLC38A2_uc001rph.2_Intron	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	83	Regulates protein turnover upon amino acid deprivation (By similarity).|Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		TGCCCACAATCGCATTGCTCA	0.393													0	0	0	0.099896	0	24	105										G	46764360	C	G	46764360	2	3	3	1	0	0	0	0	0	0	0	1	14604	871	31	1		1	SLC38A2	12	46764360	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	953784	46764360	87087535	71	361										
SLC38A2	54407	broad.mit.edu	37	chr12	46765071	46765071	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aatcgtcccatttcggccttCttcatgctaagcactgggag	9	12	2	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:46765071C>G	uc001rpg.2	-	2	446	c.6G>C	c.(4-6)AAG>AAC	p.K2N	SLC38A2_uc001rph.2_5'UTR	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	2	Cytoplasmic (Potential).|Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		TTTCGGCCTTCTTCATGCTAA	0.577													0	0	0	0.048971	0	47	136										G	46765071	C	G	46765071	3	3	3	1	0	0	0	0	1	0	0	0	14604	912	32	1	1574	1	SLC38A2	12	46765071	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	711	46765071	87086824	72	362										
WIF1	11197	broad.mit.edu	37	chr12	65448985	65448985	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atgtgcaccacagccaggctCgcagacagctagaatcaaaa	9	12	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:65448985C>T	uc001ssk.2	-	9	1076	c.931G>A	c.(931-933)GAG>AAG	p.E311K		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	311	EGF-like 5.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		CAGCCAGGCTCGCAGACAGCT	0.413			T	HMGA2	pleomorphic salivary gland adenoma								0	0	0	0.024245	0	16	89										T	65448985	C	T	65448985	3	4	3	1	0	0	0	0	1	0	0	0	17363	893	31	1	216	1	WIF1	12	65448985	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	18683914	65448985	68402910	73	363										
ANO4	121601	broad.mit.edu	37	chr12	101510560	101510560	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gcagtgagttctcggggactCctcttaagtactgcaggtga	13	9	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:101510560C>A	uc010svm.1	+	25	3126	c.2554C>A	c.(2554-2556)CCT>ACT	p.P852T	ANO4_uc001thw.2_Missense_Mutation_p.P817T|ANO4_uc001thx.2_Missense_Mutation_p.P852T|ANO4_uc001thy.2_Missense_Mutation_p.P372T	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	852	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CTCGGGGACTCCTCTTAAGTA	0.542										HNSCC(74;0.22)			1	0	3.62473e-10	0.062417	3.91741e-10	23	144										A	101510560	C	A	101510560	3	1	3	1	0	0	0	0	1	0	0	0	699	855	30	3	2539	3	ANO4	12	101510560	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	36061575	101510560	32341335	74	364										
EIF2B1	1967	broad.mit.edu	37	chr12	124109399	124109399	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tatgacaagatctgctttctCcatgatgtagctaaggggaa	10	7	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr12:124109399C>A	uc001ufm.2	-	7	705	c.562G>T	c.(562-564)GAG>TAG	p.E188*	EIF2B1_uc001ufn.2_Nonsense_Mutation_p.E186*	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	188					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		TCTGCTTTCTCCATGATGTAG	0.393													1	0	4.35082e-09	0.055883	4.6731e-09	17	74										A	124109399	C	A	124109399	4	1	3	1	0	0	0	0	0	1	0	0	5000	864	30	3	367	3	EIF2B1	12	124109399	Nonsense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	22598839	124109399	9742496	75	365										
KLHL1	57626	broad.mit.edu	37	chr13	70314531	70314531	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aaaaaatttacttacttgccAttcaatgctgctacaccaac	3	11	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr13:70314531A>G	uc001vip.2	-	8	2591	c.1797T>C	c.(1795-1797)AAT>AAC	p.N599N	KLHL1_uc010thm.1_Silent_p.N538N	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	599	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTTACTTGCCATTCAATGCTG	0.318													0	0	0	0.069234	0	10	27										G	70314531	A	G	70314531	2	3	3	1	0	0	0	0	0	0	0	1	8365	214	8	5		5	KLHL1	13	70314531	Silent	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08		70314531	44855347	76	366										
DACH1	1602	broad.mit.edu	37	chr13	72049858	72049858	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	catttaagaccctgagactaTctgttgaagctgcctgtttt	8	9	1	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr13:72049858T>A	uc010thn.1	-	10	2417	c.1994A>T	c.(1993-1995)GAT>GTT	p.D665V	DACH1_uc010tho.1_Missense_Mutation_p.D517V|DACH1_uc010thp.1_Missense_Mutation_p.D463V	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	717	Potential.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CCTGAGACTATCTGTTGAAGC	0.393													0	0	0	0.048971	0	106	80										A	72049858	T	A	72049858	3	1	3	1	0	0	0	0	1	0	0	0	4220	1435	50	5	138	5	DACH1	13	72049858	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	1735327	72049858	43120020	77	367										
DOCK9	23348	broad.mit.edu	37	chr13	99520199	99520199	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tacctttgggtctccaggagCaaaacagctaatgtagttgt	10	8	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr13:99520199C>T	uc001vnt.2	-	29	3215	c.3160G>A	c.(3160-3162)GCT>ACT	p.A1054T	DOCK9_uc001vnw.2_Missense_Mutation_p.A1053T|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.A1054T|DOCK9_uc010tis.1_Missense_Mutation_p.A1053T|DOCK9_uc010tit.1_Missense_Mutation_p.A1054T|DOCK9_uc010tiq.1_Missense_Mutation_p.A18T|DOCK9_uc010afu.1_Missense_Mutation_p.A900T	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1054					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCTCCAGGAGCAAAACAGCTA	0.403													0	0	0	0.047766	0	6	21										T	99520199	C	T	99520199	3	4	3	1	0	0	0	0	1	0	0	0	4694	710	25	2	3222	2	DOCK9	13	99520199	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	27470341	99520199	15649679	78	368										
MYH7	4625	broad.mit.edu	37	chr14	23896042	23896042	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	caaagtggggatgggtggagCgcaagttggtcatcagcttg	17	6	2	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr14:23896042C>T	uc001wjx.2	-	18	2094	c.1988G>A	c.(1987-1989)CGC>CAC	p.R663H		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	663	Myosin head-like.|Actin-binding.		R -> C (in CMH1).|R -> H (in CMH1).|R -> S (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ATGGGTGGAGCGCAAGTTGGT	0.448													0	0	0	0.049695	0	18	46										T	23896042	C	T	23896042	3	4	3	1	0	0	0	0	1	0	0	0	10039	768	27	2	3911	2	MYH7	14	23896042	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		23896042	83453498	79	369										
DLST	1743	broad.mit.edu	37	chr14	75369021	75369021	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gaggatcccagagtcctcctCctggatctttaggaggaacc	11	12	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr14:75369021C>G	uc001xqv.2	+	15	1413	c.1350C>G	c.(1348-1350)CTC>CTG	p.L450L	DLST_uc001xqt.2_Silent_p.L366L|DLST_uc010tuw.1_Silent_p.L364L	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	450					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		GAGTCCTCCTCCTGGATCTTT	0.547													0	0	0	0.069234	0	9	43										G	75369021	C	G	75369021	2	3	3	1	0	0	0	0	0	0	0	1	4569	842	30	1		1	DLST	14	75369021	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	51472979	75369021	31980519	80	370										
FLRT2	23768	broad.mit.edu	37	chr14	86088847	86088847	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atggctcaaatatatcccttCatctctcaacgtgcggggtt	8	11	4	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr14:86088847C>T	uc001xvr.2	+	2	1756	c.989C>T	c.(988-990)TCA>TTA	p.S330L	FLRT2_uc010atd.2_Missense_Mutation_p.S330L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	330	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TATATCCCTTCATCTCTCAAC	0.478													0	0	0	0.048971	0	94	241										T	86088847	C	T	86088847	3	4	3	1	0	0	0	0	1	0	0	0	5939	838	29	1	991	1	FLRT2	14	86088847	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	10719826	86088847	21260693	81	371										
AHNAK2	113146	broad.mit.edu	37	chr14	105419822	105419822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aatttgttccttttttaagcGtttttcatcgtgtattagtt	6	5	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr14:105419822G>A	uc010axc.1	-	7	2086	c.1966C>T	c.(1966-1968)CGC>TGC	p.R656C	AHNAK2_uc001ypx.2_Missense_Mutation_p.R556C	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	656						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTTTTTAAGCGTTTTTCATCG	0.403													0	0	0	0.048971	0	74	350										A	105419822	G	A	105419822	3	1	3	1	0	0	0	0	1	0	0	0	415	1145	40	2	15425	2	AHNAK2	14	105419822	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	19330975	105419822	1929718	82	372										
NUDT14	256281	broad.mit.edu	37	chr14	105644073	105644073	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	caggacttctgggcaccattCtagaaggggcaggtcagcgg	15	10	3	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr14:105644073C>T	uc010tyn.1	-	2	196	c.82_splice	c.e2-1	p.N28_splice	NUDT14_uc001yqi.2_Splice_Site	NM_177533	NP_803877	O95848	NUD14_HUMAN	nudix-type motif 14							cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			skin(1)	1		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		GGGCACCATTCTAGAAGGGGC	0.617										HNSCC(42;0.11)			0	0	0	0.048971	0	50	159										T	105644073	C	T	105644073	5	4	3	1	0	0	0	0	0	0	1	0	10730	927	32	1	603	1	NUDT14	14	105644073	Splice_Site	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	224251	105644073	1705467	83	373										
RYR3	6263	broad.mit.edu	37	chr15	33872188	33872188	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ggtttttagcggaaacaatcGcacagctgcccccatcaccc	8	15	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr15:33872188G>C	uc001zhi.2	+	13	1350	c.1280G>C	c.(1279-1281)CGC>CCC	p.R427P	RYR3_uc010bar.2_Missense_Mutation_p.R427P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	427	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGAAACAATCGCACAGCTGCC	0.562													0	0	0	0.02938	0	7	28										C	33872188	G	C	33872188	3	2	3	1	0	0	0	0	1	0	0	0	13770	1087	38	4	1330	4	RYR3	15	33872188	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		33872188	68659204	84	374										
SCAPER	49855	broad.mit.edu	37	chr15	77025725	77025725	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tataaaggcaatttcatttaCctttaaaaaaacaaagaagg	5	5	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr15:77025725C>G	uc002bby.2	-	15	1926	c.1867G>C	c.(1867-1869)GTA>CTA	p.V623L	SCAPER_uc002bbx.2_Missense_Mutation_p.V377L|SCAPER_uc002bbz.1_Missense_Mutation_p.V494L|SCAPER_uc002bca.1_Missense_Mutation_p.V488L|SCAPER_uc002bcb.1_Missense_Mutation_p.V629L	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	622	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						ATTTCATTTACCTTTAAAAAA	0.284													0	0	0	0.02938	0	7	63										G	77025725	C	G	77025725	3	3	3	1	0	0	0	0	1	0	0	0	13878	521	18	4	2403	4	SCAPER	15	77025725	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	43153537	77025725	25505667	85	375										
TELO2	9894	broad.mit.edu	37	chr16	1551483	1551483	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tccccccagcctgcgggtgaCggcgcctcggaggcggggtg	18	15	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr16:1551483C>T	uc002cly.2	+	10	1635	c.1344C>T	c.(1342-1344)GAC>GAT	p.D448D		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	448						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				CTGCGGGTGACGGCGCCTCGG	0.692													0	0	0	0.105934	0	11	5										T	1551483	C	T	1551483	2	4	3	1	0	0	0	0	0	0	0	1	15754	535	19	2		2	TELO2	16	1551483	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		1551483	88803270	86	376										
POLR3E	55718	broad.mit.edu	37	chr16	22337220	22337220	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgcggtcccgcccggtgtgcGgatcaaggaggagcccgtga	17	12	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr16:22337220G>A	uc002dkk.2	+	18	1643	c.1487G>A	c.(1486-1488)CGG>CAG	p.R496Q	POLR3E_uc002dkj.1_Missense_Mutation_p.R496Q|POLR3E_uc002dkm.2_Missense_Mutation_p.R460Q|POLR3E_uc010vbr.1_Missense_Mutation_p.R496Q|POLR3E_uc002dkl.2_Missense_Mutation_p.R496Q|POLR3E_uc010vbs.1_Missense_Mutation_p.R460Q|POLR3E_uc010vbt.1_Missense_Mutation_p.R440Q	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	496					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		CCCGGTGTGCGGATCAAGGAG	0.542													0	0	0	0.047766	0	9	22										A	22337220	G	A	22337220	3	1	3	1	0	0	0	0	1	0	0	0	12232	1116	39	2	1553	2	POLR3E	16	22337220	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	20785737	22337220	68017533	87	377										
ZNF668	79759	broad.mit.edu	37	chr16	31075213	31075213	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gtagggccgcaggccagcgtGagtacgccggtgcttgcgga	18	11	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr16:31075213G>A	uc010caf.2	-	2	925	c.568C>T	c.(568-570)CAC>TAC	p.H190Y	ZNF668_uc002eao.2_Missense_Mutation_p.H190Y|ZNF668_uc010cag.1_Missense_Mutation_p.H190Y	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	190	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						AGGCCAGCGTGAGTACGCCGG	0.657													0	0	0	0.047766	0	9	14										A	31075213	G	A	31075213	3	1	3	1	0	0	0	0	1	0	0	0	18072	1290	45	1	1299	1	ZNF668	16	31075213	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	8737993	31075213	59279540	88	378										
EDC4	23644	broad.mit.edu	37	chr16	67911712	67911712	+	Frame_Shift_Del	DEL	C	C	-													0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cctgtggatgttagccagatCaagcagggcttcattgtggt							TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr16:67911712delC	uc002eur.2	+	7	1024	c.858delC	c.(856-858)ATCfs	p.I286fs	EDC4_uc010cer.2_5'UTR|EDC4_uc010vkg.1_Frame_Shift_Del_p.I218fs|EDC4_uc010ces.1_Frame_Shift_Del_p.I129fs|EDC4_uc002eus.2_Frame_Shift_Del_p.I16fs	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	286					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TTAGCCAGATCAAGCAGGGCT	0.582																		55	86	---	---								-	67911712	C	-	67911712	7	5	3	1	0	1	0	1	0	0	0	0	4908	816	29	0	884	0	EDC4	16	67911712	Frame_Shift_Del	DEL	C	TCGA-BL-A13J-01A-11D-A10S-08	36836499	67911712	22443041	89	379										
CNTNAP4	85445	broad.mit.edu	37	chr16	76569457	76569457	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tttaggtggaacggccaccaGacagagaggctttctgggct	14	9	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr16:76569457G>A	uc002feu.1	+	20	3156	c.2771G>A	c.(2770-2772)AGA>AAA	p.R924K	CNTNAP4_uc002fev.1_Missense_Mutation_p.R788K|CNTNAP4_uc010chb.1_Missense_Mutation_p.R851K|CNTNAP4_uc002fex.1_Missense_Mutation_p.R927K	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	924	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						ACGGCCACCAGACAGAGAGGC	0.483													0	0	0	0.043863	0	18	77										A	76569457	G	A	76569457	3	1	3	1	0	0	0	0	1	0	0	0	3649	942	33	1	2854	1	CNTNAP4	16	76569457	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	8657745	76569457	13785296	90	380										
TP53	7157	broad.mit.edu	37	chr17	7578190	7578190	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	accagacctcaggcggctcaTagggcaccaccacactatgt	9	15	2	1	rs121912666		TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:7578190T>C	uc002gim.2	-	6	853	c.659A>G	c.(658-660)TAT>TGT	p.Y220C	TP53_uc002gig.1_Missense_Mutation_p.Y220C|TP53_uc002gih.2_Missense_Mutation_p.Y220C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y88C|TP53_uc010cng.1_Missense_Mutation_p.Y88C|TP53_uc002gii.1_Missense_Mutation_p.Y88C|TP53_uc010cnh.1_Missense_Mutation_p.Y220C|TP53_uc010cni.1_Missense_Mutation_p.Y220C|TP53_uc002gij.2_Missense_Mutation_p.Y220C|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y127C|TP53_uc002gio.2_Missense_Mutation_p.Y88C|TP53_uc010vug.1_Missense_Mutation_p.Y181C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	220	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> S (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y220C(205)|p.Y220N(12)|p.Y220H(9)|p.Y220S(9)|p.0?(7)|p.Y220fs*27(4)|p.Y220*(3)|p.Y220D(2)|p.Y127C(2)|p.D208fs*1(1)|p.Y220_P223delYEPP(1)|p.?(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.V218_Y220delVPY(1)|p.Y220fs*25(1)|p.V216_Y220delVVVPY(1)|p.Y220fs*1(1)|p.Y220fs*2(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGCGGCTCATAGGGCACCAC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.050027	0	31	17										C	7578190	T	C	7578190	3	2	3	1	0	0	0	0	1	0	0	0	16378	1406	49	5	635	5	TP53	17	7578190	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08		7578190	73617020	91	381										
USP43	124739	broad.mit.edu	37	chr17	9631804	9631804	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agaaggccatgaactggaagGagagcttccagatgggaagc	15	7	0	4			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:9631804G>T	uc010cod.2	+	15	2869	c.2869G>T	c.(2869-2871)GAG>TAG	p.E957*	USP43_uc002gma.3_Nonsense_Mutation_p.E646*|USP43_uc010vva.1_Nonsense_Mutation_p.E952*|USP43_uc010coe.2_Nonsense_Mutation_p.E754*|USP43_uc002gmc.3_Nonsense_Mutation_p.E469*	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	957					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GAACTGGAAGGAGAGCTTCCA	0.552													1	0	9.05144e-12	0.105934	1.00315e-11	12	28										T	9631804	G	T	9631804	4	4	3	1	0	0	0	0	0	1	0	0	17071	1175	41	3	2927	3	USP43	17	9631804	Nonsense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	2053614	9631804	71563406	92	382										
CPD	1362	broad.mit.edu	37	chr17	28778804	28778804	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agagagctcaagagaaagacTgtacttcaaaaataggacaa	9	6	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:28778804T>A	uc002hfb.1	+	14	3160	c.3145T>A	c.(3145-3147)TGT>AGT	p.C1049S	CPD_uc010wbo.1_Missense_Mutation_p.C802S|CPD_uc010wbp.1_Intron	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1049	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AGAGAAAGACTGTACTTCAAA	0.388													0	0	0	0.105934	0	14	91										A	28778804	T	A	28778804	3	1	3	1	0	0	0	0	1	0	0	0	3798	1580	55	5	3199	5	CPD	17	28778804	Missense_Mutation	SNP	T	TCGA-BL-A13J-01A-11D-A10S-08	19147000	28778804	52416406	93	383										
RARA	5914	broad.mit.edu	37	chr17	38510626	38510626	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cggacgggctgaccctgaacCggacccagatgcacaacgct	12	15	0	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:38510626C>T	uc002huk.1	+	7	1335	c.880C>T	c.(880-882)CGG>TGG	p.R294W	RARA_uc002hul.3_Missense_Mutation_p.R294W|RARA_uc010wfe.1_Missense_Mutation_p.R197W|RARA_uc002hun.1_Missense_Mutation_p.R289W	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	294	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	GACCCTGAACCGGACCCAGAT	0.642			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								0	0	0	0.076483	0	21	93										T	38510626	C	T	38510626	3	4	3	1	0	0	0	0	1	0	0	0	13052	643	23	2	1069	2	RARA	17	38510626	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	9731822	38510626	42684584	94	384										
HOXB4	3214	broad.mit.edu	37	chr17	46654110	46654110	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cgcgcgggggcctccattggGccggccagggggccctccgg	19	16	0	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:46654110G>A	uc002inp.2	-	2	792	c.730C>T	c.(730-732)CCC>TCC	p.P244S	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	244						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCTCCATTGGGCCGGCCAGGG	0.697													0	0	0	0.080935	0	11	50										A	46654110	G	A	46654110	3	1	3	1	0	0	0	0	1	0	0	0	7303	1203	42	2	29	2	HOXB4	17	46654110	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	8143484	46654110	34541100	95	385										
BCAS3	54828	broad.mit.edu	37	chr17	58952079	58952079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctttgatagctgtactttcaCgaagaaattctttgttacaa	6	7	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:58952079C>T	uc002iyv.3	+	9	750	c.641C>T	c.(640-642)ACG>ATG	p.T214M	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Missense_Mutation_p.T214M|BCAS3_uc002iyw.3_Missense_Mutation_p.T210M	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	214						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TGTACTTTCACGAAGAAATTC	0.328													0	0	0	0.080935	0	10	51										T	58952079	C	T	58952079	3	4	3	1	0	0	0	0	1	0	0	0	1352	536	19	2	671	2	BCAS3	17	58952079	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	12297969	58952079	22243131	96	386										
CD300LF	146722	broad.mit.edu	37	chr17	72691301	72691301	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctgccggggaggtggctactGaggtggcccatgttgcagta	17	9	0	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr17:72691301G>A	uc002jlg.2	-	7	910	c.807C>T	c.(805-807)CTC>CTT	p.L269L	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Silent_p.L272L|CD300LF_uc010dfw.2_RNA|CD300LF_uc002jlh.2_3'UTR|CD300LF_uc002jli.2_3'UTR|CD300LF_uc010wra.1_Silent_p.L284L	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	269	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1						GGTGGCTACTGAGGTGGCCCA	0.602													0	0	0	0.030593	0	26	90										A	72691301	G	A	72691301	2	1	3	1	0	0	0	0	0	0	0	1	3001	1277	45	1		1	CD300LF	17	72691301	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	13739222	72691301	8503909	97	387										
CDH2	1000	broad.mit.edu	37	chr18	25593677	25593677	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tcctcagttaaggttggcttCaggctcaattttactgccac	8	11	3	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr18:25593677C>T	uc002kwg.2	-	3	828	c.369G>A	c.(367-369)CTG>CTA	p.L123L	CDH2_uc010xbn.1_Silent_p.L92L	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	123					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						AGGTTGGCTTCAGGCTCAATT	0.418													0	0	0	0.048971	0	51	205										T	25593677	C	T	25593677	2	4	3	1	0	0	0	0	0	0	0	1	3105	813	29	1		1	CDH2	18	25593677	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		25593677	52483571	98	388										
TCF4	6925	broad.mit.edu	37	chr18	52946874	52946874	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgtagtcggcagtgcttgctGatggagcatagacctgagga	15	7	0	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr18:52946874G>C	uc002lfz.2	-	9	1175	c.563C>G	c.(562-564)TCA>TGA	p.S188*	TCF4_uc002lfw.3_Nonsense_Mutation_p.S28*|TCF4_uc010xdu.1_Nonsense_Mutation_p.S58*|TCF4_uc010xdv.1_Nonsense_Mutation_p.S58*|TCF4_uc002lfx.2_Nonsense_Mutation_p.S117*|TCF4_uc010xdw.1_Nonsense_Mutation_p.S58*|TCF4_uc002lfy.2_Nonsense_Mutation_p.S146*|TCF4_uc010xdx.1_Nonsense_Mutation_p.S164*|TCF4_uc010dph.1_Nonsense_Mutation_p.S188*|TCF4_uc010xdy.1_Nonsense_Mutation_p.S164*|TCF4_uc002lga.2_Nonsense_Mutation_p.S290*|TCF4_uc002lgb.1_Nonsense_Mutation_p.S28*|TCF4_uc010dpi.2_Nonsense_Mutation_p.S194*|TCF4_uc002lgc.3_Nonsense_Mutation_p.S109*|TCF4_uc002lfv.2_Translation_Start_Site	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	188					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		AGTGCTTGCTGATGGAGCATA	0.478													0	0	0	0.069234	0	9	60										C	52946874	G	C	52946874	4	2	3	1	0	0	0	0	0	1	0	0	15692	1294	45	1	1496	1	TCF4	18	52946874	Nonsense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	27353197	52946874	25130374	99	389										
PHLPP1	23239	broad.mit.edu	37	chr18	60562283	60562283	+	Frame_Shift_Del	DEL	T	T	-													0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cttaacctttccaataatcaTttaggggacttcccactggc							TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr18:60562283delT	uc002lis.2	+	6	748	c.570delT	c.(568-570)CATfs	p.H190fs		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	702	LRR 3.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CCAATAATCATTTAGGGGACT	0.438																		18	28	---	---								-	60562283	T	-	60562283	7	5	3	1	0	1	0	1	0	0	0	0	11854	1490	52	0	2124	0	PHLPP1	18	60562283	Frame_Shift_Del	DEL	T	TCGA-BL-A13J-01A-11D-A10S-08	7615409	60562283	17514965	100	390										
SERPINB13	5275	broad.mit.edu	37	chr18	61255985	61255985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acaaatgatggcaacatcttCttttcccctgtgggcatctt	7	11	3	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr18:61255985C>G	uc002ljc.2	+	2	252	c.84C>G	c.(82-84)TTC>TTG	p.F28L	SERPINB13_uc002ljd.2_5'UTR|SERPINB13_uc010xep.1_Missense_Mutation_p.F28L|SERPINB13_uc010xeq.1_5'UTR|SERPINB13_uc010xer.1_5'UTR	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	28					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						GCAACATCTTCTTTTCCCCTG	0.532													0	0	0	0.043863	0	19	53										G	61255985	C	G	61255985	3	3	3	1	0	0	0	0	1	0	0	0	14100	912	32	1	86	1	SERPINB13	18	61255985	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	693702	61255985	16821263	101	391										
TMX3	54495	broad.mit.edu	37	chr18	66381117	66381117	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ttctacaaatcctttacagaCgaccatatcaagtacaacaa	3	11	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr18:66381117C>T	uc002lkf.2	-	2	202	c.67G>A	c.(67-69)GTC>ATC	p.V23I	CCDC102B_uc002lkk.2_5'Flank|TMX3_uc010xez.1_5'UTR|TMX3_uc010xfa.1_Missense_Mutation_p.V23I|TMX3_uc002lkg.3_Missense_Mutation_p.V23I|CCDC102B_uc002lkh.2_5'Flank	NM_019022	NP_061895	Q96JJ7	TMX3_HUMAN	thioredoxin domain containing 10 precursor	23					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			skin(1)	1						CCTTTACAGACGACCATATCA	0.294													0	0	0	0.009096	0	4	15										T	66381117	C	T	66381117	3	4	3	1	0	0	0	0	1	0	0	0	16265	536	19	2	1357	2	TMX3	18	66381117	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	5125132	66381117	11696131	102	392										
ZNF516	9658	broad.mit.edu	37	chr18	74153297	74153297	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agcagcggcacaggcggagcCagggctgctgggctgggagg	21	10	0	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr18:74153297C>T	uc010dqx.1	-	2	1949	c.1714G>A	c.(1714-1716)GGC>AGC	p.G572S	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CAGGCGGAGCCAGGGCTGCTG	0.736													0	0	0	0.02938	0	6	15										T	74153297	C	T	74153297	3	4	3	1	0	0	0	0	1	0	0	0	17957	594	21	2	1798	2	ZNF516	18	74153297	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	7772180	74153297	3923951	103	393										
ZNF555	148254	broad.mit.edu	37	chr19	2852822	2852822	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctcagaagtcacaccggagaGaagccatataagtgtaagga	11	8	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:2852822G>A	uc002lwo.2	+	4	848	c.759G>A	c.(757-759)GAG>GAA	p.E253E	ZNF555_uc002lwn.3_Silent_p.E252E	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	253					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACCGGAGAGAAGCCATATA	0.413													0	0	0	0.09319	0	12	64										A	2852822	G	A	2852822	2	1	3	1	0	0	0	0	0	0	0	1	17983	933	33	1		1	ZNF555	19	2852822	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		2852822	56276161	104	394										
OR2Z1	284383	broad.mit.edu	37	chr19	8842207	8842207	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	acagtccacagcaggataacGtggtttccctcttctatagc	8	12	2	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:8842207G>A	uc010xkg.1	+	1	817	c.817G>A	c.(817-819)GTG>ATG	p.V273M		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						GCAGGATAACGTGGTTTCCCT	0.537													0	0	0	0.108266	0	27	160										A	8842207	G	A	8842207	3	1	3	1	0	0	0	0	1	0	0	0	11036	1145	40	2	819	2	OR2Z1	19	8842207	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	5989385	8842207	50286776	105	395										
CARM1	10498	broad.mit.edu	37	chr19	11032381	11032381	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	catgggcggccccgccatctCcatggcgtcgcccatgtcca	11	18	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:11032381C>A	uc002mpz.2	+	16	1901	c.1775C>A	c.(1774-1776)TCC>TAC	p.S592Y	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Missense_Mutation_p.S352Y	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	592	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						CCCGCCATCTCCATGGCGTCG	0.652													1	0	5.66738e-07	0.086207	5.90493e-07	34	156										A	11032381	C	A	11032381	3	1	3	1	0	0	0	0	1	0	0	0	2655	855	30	3	1837	3	CARM1	19	11032381	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	2190174	11032381	48096602	106	396										
ZNF714	148206	broad.mit.edu	37	chr19	21281118	21281118	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	caaaaacctggtcttcttggGtgagaataactttaatacat	7	7	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:21281118G>A	uc002npo.3	+	3	403	c.43_splice	c.e3+1	p.A15_splice	ZNF714_uc002npl.2_Splice_Site|ZNF714_uc010ecp.1_Splice_Site|ZNF714_uc002npn.2_Splice_Site	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCTTCTTGGGTGAGAATAAC	0.328													0	0	0	0.069288	0	22	65										A	21281118	G	A	21281118	5	1	3	1	0	0	0	0	0	0	1	0	18115	1275	44	2	46	2	ZNF714	19	21281118	Splice_Site	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	10248737	21281118	37847865	107	397										
ZNF99	7652	broad.mit.edu	37	chr19	22939544	22939544	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tatgaattatcttatgtttcAtaagggttgaggaattgtta	9	2	2	2	rs58378942		TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:22939544A>C	uc010xrh.1	-	7	2627	c.2627T>G	c.(2626-2628)ATG>AGG	p.M876R		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTTATGTTTCATAAGGGTTGA	0.343													0	0	0	0.004672	0	3	69										C	22939544	A	C	22939544	3	2	3	1	0	0	0	0	1	0	0	0	18201	217	8	5	489	5	ZNF99	19	22939544	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	1658426	22939544	36189439	108	398										
ARHGEF1	9138	broad.mit.edu	37	chr19	42410144	42410144	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ccttctgcagaccaggccccGagggccagctcgctgccacg	12	18	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:42410144G>A	uc002orx.2	+	26	2567	c.2458G>A	c.(2458-2460)GAG>AAG	p.E820K	ARHGEF1_uc002ory.2_Missense_Mutation_p.E787K|ARHGEF1_uc002orz.2_Missense_Mutation_p.E658K|ARHGEF1_uc002osa.2_Missense_Mutation_p.E835K|ARHGEF1_uc002osb.2_Missense_Mutation_p.E802K|ARHGEF1_uc002osc.2_Missense_Mutation_p.E574K|ARHGEF1_uc002osd.2_Missense_Mutation_p.E479K|ARHGEF1_uc002ose.2_Missense_Mutation_p.E264K	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	820					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACCAGGCCCCGAGGGCCAGCT	0.512													0	0	0	0.034045	0	26	125										A	42410144	G	A	42410144	3	1	3	1	0	0	0	0	1	0	0	0	893	1059	37	1	2605	1	ARHGEF1	19	42410144	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	19470600	42410144	16718839	109	399										
ZNF285	26974	broad.mit.edu	37	chr19	44891096	44891096	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgaaggtgtgtacattggctGaagccctttccacactcacc	9	12	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:44891096G>A	uc002ozd.3	-	4	1398	c.1311C>T	c.(1309-1311)TTC>TTT	p.F437F	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Silent_p.F444F	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	437	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TACATTGGCTGAAGCCCTTTC	0.473													0	0	0	0.055883	0	21	109										A	44891096	G	A	44891096	2	1	3	1	0	0	0	0	0	0	0	1	17819	1281	45	1		1	ZNF285	19	44891096	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	2480952	44891096	14237887	110	400										
ZNF813	126017	broad.mit.edu	37	chr19	53994369	53994369	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gccatcgtagacttcatactGgagagaaaccttacaaatgt	8	9	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:53994369G>T	uc002qbu.2	+	4	1011	c.883G>T	c.(883-885)GGA>TGA	p.G295*	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ACTTCATACTGGAGAGAAACC	0.398													1	0	1.01871e-10	0.049695	1.11482e-10	19	119										T	53994369	G	T	53994369	4	4	3	1	0	0	0	0	0	1	0	0	18172	1349	47	4	893	4	ZNF813	19	53994369	Nonsense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	9103273	53994369	5134614	111	401										
LILRA2	11027	broad.mit.edu	37	chr19	55085807	55085807	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cctctgggctgagccaggctCtgtgatcatccagggaagtc	13	12	3	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:55085807C>T	uc002qgg.3	+	3	199	c.110C>T	c.(109-111)TCT>TTT	p.S37F	LILRA2_uc010ern.2_Missense_Mutation_p.S37F|LILRA2_uc002qgf.2_Missense_Mutation_p.S37F|LILRA2_uc010yfe.1_Missense_Mutation_p.S37F|LILRA2_uc010yff.1_Missense_Mutation_p.S25F|LILRA2_uc010ero.2_Missense_Mutation_p.S25F|LILRA2_uc010yfg.1_Missense_Mutation_p.S37F	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	37	Extracellular (Potential).|Ig-like C2-type 1.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GAGCCAGGCTCTGTGATCATC	0.542													0	0	0	0.048971	0	99	157										T	55085807	C	T	55085807	3	4	3	1	0	0	0	0	1	0	0	0	8785	913	32	1	120	1	LILRA2	19	55085807	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	1091438	55085807	4043176	112	402										
NLRP2	55655	broad.mit.edu	37	chr19	55493697	55493697	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ccttctcatacacggtggtgCtgtatggtcctgcaggcctt	11	12	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:55493697C>T	uc002qij.2	+	6	717	c.631C>T	c.(631-633)CTG>TTG	p.L211L	NLRP2_uc010yfp.1_Silent_p.L188L|NLRP2_uc010esn.2_Silent_p.L187L|NLRP2_uc010eso.2_Silent_p.L208L|NLRP2_uc010esp.2_Silent_p.L189L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	211	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CACGGTGGTGCTGTATGGTCC	0.517													0	0	0	0.048971	0	63	125										T	55493697	C	T	55493697	2	4	3	1	0	0	0	0	0	0	0	1	10477	796	28	2		2	NLRP2	19	55493697	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	407890	55493697	3635286	113	403										
ZIM3	114026	broad.mit.edu	37	chr19	57647056	57647056	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atagggcctttcctctgcgtGagttttctgatgtttatcaa	9	8	3	2	rs150862431		TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr19:57647056G>C	uc002qnz.1	-	5	1035	c.649C>G	c.(649-651)CAC>GAC	p.H217D		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	217	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCTCTGCGTGAGTTTTCTGA	0.428													0	0	0	0.092188	0	40	209										C	57647056	G	C	57647056	3	2	3	1	0	0	0	0	1	0	0	0	17682	1290	45	1	773	1	ZIM3	19	57647056	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	2153359	57647056	1481927	114	404										
C20orf96	140680	broad.mit.edu	37	chr20	256641	256641	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	agcagaacatcctcaaatatGacctctcggggttcccgggt	10	12	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr20:256641G>C	uc002wde.1	-	10	1138	c.999C>G	c.(997-999)GTC>GTG	p.V333V	C20orf96_uc002wdc.2_Silent_p.V280V|C20orf96_uc002wdd.2_Silent_p.V298V|C20orf96_uc010zpi.1_Silent_p.V280V|C20orf96_uc010zpj.1_3'UTR|C20orf96_uc010zpk.1_3'UTR	NM_153269	NP_695001	Q9NUD7	CT096_HUMAN	hypothetical protein LOC140680	333											0		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCTCAAATATGACCTCTCGGG	0.512													0	0	0	0.038395	0	18	80										C	256641	G	C	256641	2	2	3	1	0	0	0	0	0	0	0	1	2122	1277	45	1		1	C20orf96	20	256641	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		256641	62768879	115	405										
SIRPB2	284759	broad.mit.edu	37	chr20	1459226	1459226	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ttcctggggctggatgatccAcaggtctggttcagggtccc	14	11	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr20:1459226A>C	uc002wfg.2	-	3	706	c.478T>G	c.(478-480)TGG>GGG	p.W160G	SIRPB2_uc002wfh.3_Missense_Mutation_p.W62G|SIRPB2_uc010zpr.1_Missense_Mutation_p.W22G	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	160	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0						TGGATGATCCACAGGTCTGGT	0.443													0	0	0	0.069234	0	10	76										C	1459226	A	C	1459226	3	2	3	1	0	0	0	0	1	0	0	0	14334	159	6	5	562	5	SIRPB2	20	1459226	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	1202585	1459226	61566294	116	406										
CRNKL1	51340	broad.mit.edu	37	chr20	20026049	20026049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cagctctctcatacactttcCgtgcatgggcaaaataagca	7	12	2	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr20:20026049C>T	uc002wrs.2	-	7	1219	c.1187G>A	c.(1186-1188)CGG>CAG	p.R396Q		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	396	HAT 6.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						ATACACTTTCCGTGCATGGGC	0.418													0	0	0	0.104719	0	44	190										T	20026049	C	T	20026049	3	4	3	1	0	0	0	0	1	0	0	0	3891	652	23	2	1395	2	CRNKL1	20	20026049	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	18566823	20026049	42999471	117	407										
TGM2	7052	broad.mit.edu	37	chr20	36758657	36758657	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atgacattccggaagcccttCacagccttcagcttgtcgct	8	14	2	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr20:36758657C>T	uc002xhr.2	-	13	2128	c.2028G>A	c.(2026-2028)GTG>GTA	p.V676V	TGM2_uc002xhq.2_Silent_p.V277V|TGM2_uc010zvx.1_Silent_p.V595V|TGM2_uc010zvy.1_Silent_p.V616V	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	676					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	GGAAGCCCTTCACAGCCTTCA	0.587													0	0	0	0.009096	0	4	31										T	36758657	C	T	36758657	2	4	3	1	0	0	0	0	0	0	0	1	15827	813	29	1		1	TGM2	20	36758657	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	16732608	36758657	26266863	118	408										
CDH22	64405	broad.mit.edu	37	chr20	44856245	44856245	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ggtcatccgcatccgaggccAtcacctgcatcaccgacgtg	10	16	3	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr20:44856245A>T	uc002xrm.2	-	3	973	c.572T>A	c.(571-573)ATG>AAG	p.M191K	CDH22_uc010ghk.1_Missense_Mutation_p.M191K	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	191	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				ATCCGAGGCCATCACCTGCAT	0.682													0	0	0	0.043863	0	12	5										T	44856245	A	T	44856245	3	4	3	1	0	0	0	0	1	0	0	0	3107	217	8	5	1950	5	CDH22	20	44856245	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	8097588	44856245	18169275	119	409										
ZNF831	128611	broad.mit.edu	37	chr20	57767955	57767955	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	caggtgtacggggatgagacGttcaaaaggatctaccagaa	13	7	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr20:57767955G>T	uc002yan.2	+	1	1881	c.1881G>T	c.(1879-1881)ACG>ACT	p.T627T		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	627						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGATGAGACGTTCAAAAGGA	0.592													1	0	2.68362e-12	0.09319	2.99327e-12	11	85										T	57767955	G	T	57767955	2	4	3	1	0	0	0	0	0	0	0	1	18182	1132	40	4		4	ZNF831	20	57767955	Silent	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	12911710	57767955	5257565	120	410										
TIAM1	7074	broad.mit.edu	37	chr21	32575277	32575277	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	atagagctgcattttgttttCtattagaaatttcaggcgca	8	6	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr21:32575277C>T	uc002yow.1	-	13	2912	c.2440G>A	c.(2440-2442)GAA>AAA	p.E814K	TIAM1_uc011adk.1_Missense_Mutation_p.E814K|TIAM1_uc011adl.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	814	RBD.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ATTTTGTTTTCTATTAGAAAT	0.378													0	0	0	0.030593	0	26	207										T	32575277	C	T	32575277	3	4	3	1	0	0	0	0	1	0	0	0	15887	922	32	1	2403	1	TIAM1	21	32575277	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		32575277	15554618	121	411										
ITSN1	6453	broad.mit.edu	37	chr21	35255954	35255954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgaccgcgtctatactctccGagcagaaagcataaatgaaa	8	10	2	3			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr21:35255954G>A	uc002yta.1	+	36	4923	c.4655G>A	c.(4654-4656)CGA>CAA	p.R1552Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002ytb.1_Missense_Mutation_p.R1547Q|ITSN1_uc002ytj.2_Missense_Mutation_p.R1491Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc010gmn.1_RNA|ITSN1_uc002ytk.1_Intron	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	1552	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TATACTCTCCGAGCAGAAAGC	0.537													0	0	0	0.037714	0	29	199										A	35255954	G	A	35255954	3	1	3	1	0	0	0	0	1	0	0	0	7926	1058	37	1	4799	1	ITSN1	21	35255954	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	2680677	35255954	12873941	122	412										
MCM3AP	8888	broad.mit.edu	37	chr21	47674341	47674341	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ggggactgctcctctacatcCggcaacaccagcaccagctt	9	16	1	0			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr21:47674341C>T	uc002zir.1	-	19	4137	c.4101G>A	c.(4099-4101)CCG>CCA	p.P1367P	MCM3AP_uc002zip.1_Silent_p.P108P|MCM3AP_uc002ziq.1_Silent_p.P294P	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1367					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CCTCTACATCCGGCAACACCA	0.617													0	0	0	0.047766	0	9	153										T	47674341	C	T	47674341	2	4	3	1	0	0	0	0	0	0	0	1	9388	639	23	2		2	MCM3AP	21	47674341	Silent	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	12418387	47674341	455554	123	413										
UPB1	51733	broad.mit.edu	37	chr22	24909450	24909450	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cccagagtgggtgatttcaaCgaggtgagccacccataaga	12	10	1	4	rs138608016		TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr22:24909450C>A	uc003aaf.2	+	5	739	c.618C>A	c.(616-618)AAC>AAA	p.N206K	UPB1_uc003aae.2_Missense_Mutation_p.N138K|UPB1_uc011ajt.1_Missense_Mutation_p.N206K	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	206	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding	p.N206N(1)		ovary(2)	2	Colorectal(2;0.0339)					GTGATTTCAACGAGGTGAGCC	0.512													1	0	5.21738e-30	0.048971	6.01208e-30	76	49										A	24909450	C	A	24909450	3	1	3	1	0	0	0	0	1	0	0	0	16999	535	19	4	636	4	UPB1	22	24909450	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08		24909450	26395116	124	414										
AP1B1	162	broad.mit.edu	37	chr22	29730359	29730359	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	cctggcgggtgaaggtgcctGagatctccagccccttagcc	13	14	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chr22:29730359G>C	uc003afj.2	-	17	2388	c.2204C>G	c.(2203-2205)TCA>TGA	p.S735*	AP1B1_uc003afi.2_Nonsense_Mutation_p.S728*|AP1B1_uc003afk.2_Nonsense_Mutation_p.S728*|AP1B1_uc003afl.2_Intron|AP1B1_uc003afh.2_5'Flank|AP1B1_uc011ako.1_Nonsense_Mutation_p.S288*|SNORD125_uc010gvn.1_5'Flank	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	735					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GAAGGTGCCTGAGATCTCCAG	0.617													0	0	0	0.09319	0	13	37										C	29730359	G	C	29730359	4	2	3	1	0	0	0	0	0	1	0	0	731	1294	45	1	673	1	AP1B1	22	29730359	Nonsense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08	4820909	29730359	21574207	125	415										
SLC7A3	84889	broad.mit.edu	37	chrX	70149567	70149567	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	tgtagagatatgccgaaccaGaacggggaacccgggcacca	13	11	0	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chrX:70149567G>C	uc004dyn.2	-	2	439	c.281C>G	c.(280-282)TCT>TGT	p.S94C	SLC7A3_uc004dyo.2_Missense_Mutation_p.S94C	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	94	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TGCCGAACCAGAACGGGGAAC	0.542													0	0	0	0.080935	0	10	16										C	70149567	G	C	70149567	3	2	3	1	0	0	0	0	1	0	0	0	14698	942	33	1	1622	1	SLC7A3	23	70149567	Missense_Mutation	SNP	G	TCGA-BL-A13J-01A-11D-A10S-08		70149567	85120993	126	416										
PHKA1	5255	broad.mit.edu	37	chrX	71839145	71839145	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	aataacttcgtaggaagataCatgtgaacatctgcaaaaat	7	6	1	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chrX:71839145C>T	uc004eax.3	-	20	2449	c.2148G>A	c.(2146-2148)ATG>ATA	p.M716I	PHKA1_uc004eay.3_Missense_Mutation_p.M716I|PHKA1_uc011mqi.1_Missense_Mutation_p.M657I	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	716					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					TAGGAAGATACATGTGAACAT	0.388													0	0	0	0.069234	0	10	4										T	71839145	C	T	71839145	3	4	3	1	0	0	0	0	1	0	0	0	11843	478	17	2	1575	2	PHKA1	23	71839145	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	1689578	71839145	83431415	127	417										
MAGEE2	139599	broad.mit.edu	37	chrX	75003748	75003748	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ctgattctggttgctggacaAggaggtagatgtgctcactg	14	7	2	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chrX:75003748A>G	uc004ecj.1	-	1	1324	c.1139T>C	c.(1138-1140)CTT>CCT	p.L380P		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	380	MAGE 2.									ovary(1)|skin(1)	2						TTGCTGGACAAGGAGGTAGAT	0.443													0	0	0	0.074837	0	38	82										G	75003748	A	G	75003748	3	3	3	1	0	0	0	0	1	0	0	0	9186	72	3	5	436	5	MAGEE2	23	75003748	Missense_Mutation	SNP	A	TCGA-BL-A13J-01A-11D-A10S-08	3164603	75003748	80266812	128	418										
PAK3	5063	broad.mit.edu	37	chrX	110463610	110463610	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	catttttaaaattagccaagCctctctccagcctgactcct	4	14	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chrX:110463610C>A	uc004epa.2	+	15	1642	c.1615C>A	c.(1615-1617)CCT>ACT	p.P539T	PAK3_uc010npt.1_Missense_Mutation_p.P524T|PAK3_uc010npu.1_Missense_Mutation_p.P524T|PAK3_uc004eoz.2_Missense_Mutation_p.P524T|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.P560T|PAK3_uc010npw.1_Missense_Mutation_p.P545T	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	539					multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						ATTAGCCAAGCCTCTCTCCAG	0.418										TSP Lung(19;0.15)			1	0	0.000274275	0.047766	0.00028239	9	16										A	110463610	C	A	110463610	3	1	3	1	0	0	0	0	1	0	0	0	11402	739	26	4	1740	4	PAK3	23	110463610	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	35459862	110463610	44806950	129	419										
STAG2	10735	broad.mit.edu	37	chrX	123200039	123200039	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	ttacagtgcccatgacctttCaaagtgggatttatttgctt	8	8	1	1			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chrX:123200039C>T	uc004etz.3	+	21	2450	c.2111C>T	c.(2110-2112)TCA>TTA	p.S704L	STAG2_uc004eua.2_Missense_Mutation_p.S704L|STAG2_uc004eub.2_Missense_Mutation_p.S704L|STAG2_uc004euc.2_Missense_Mutation_p.S704L|STAG2_uc004eud.2_Missense_Mutation_p.S704L|STAG2_uc004eue.2_Missense_Mutation_p.S704L	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	704					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CATGACCTTTCAAAGTGGGAT	0.289													0	0	0	0.049695	0	19	51										T	123200039	C	T	123200039	3	4	3	1	0	0	0	0	1	0	0	0	15242	838	29	1	2189	1	STAG2	23	123200039	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	12736429	123200039	32070521	130	420										
F8	2157	broad.mit.edu	37	chrX	154124398	154124398	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.305343511450382	40	8.5735086081224e-11	2.99741602067183	4.95510335917313	1.95331610680448	0.274637206735141	0.465572903564617	27	gataagtctgccacttcttcCcatcaagactatacatgatg	6	11	3	2			TCGA-BL-A13J-01A-11D-A10S-08	TCGA-BL-A13J-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c7aca3f-e006-4de3-afc2-20b4f727d4fd	e34479b8-834f-4747-984b-e77272f1379d	g.chrX:154124398C>G	uc004fmt.2	-	22	6554	c.6383G>C	c.(6382-6384)GGG>GCG	p.G2128A	F8_uc010nvi.1_3'UTR	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2128	F5/8 type C 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCACTTCTTCCCATCAAGACT	0.413													0	0	0	0.048971	0	62	92										G	154124398	C	G	154124398	3	3	3	1	0	0	0	0	1	0	0	0	5350	623	22	4	720	4	F8	23	154124398	Missense_Mutation	SNP	C	TCGA-BL-A13J-01A-11D-A10S-08	30924359	154124398	1146162	131	421										
CCNL2	81669	broad.mit.edu	37	chr1	1325721	1325721	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gatagcgtgctttcttttttCcacttcaccctccaggtgtg	8	12	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:1325721C>A	uc001afi.2	-	8	927	c.895G>T	c.(895-897)GAA>TAA	p.E299*	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Nonsense_Mutation_p.E77*|CCNL2_uc001afg.1_Nonsense_Mutation_p.E77*|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	299					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		TTTCTTTTTTCCACTTCACCC	0.552													1	0	1.59361e-14	0.027894	1.70787e-14	35	56										A	1325721	C	A	1325721	4	1	4	1	0	0	0	0	0	1	0	0	2932	864	30	3	683	3	CCNL2	1	1325721	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		1325721	247924900	1	422										
PGD	5226	broad.mit.edu	37	chr1	10471526	10471526	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agatggtgcacaacgggataGagtatggggacatgcagctg	16	6	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:10471526G>C	uc001arc.2	+	7	661	c.571G>C	c.(571-573)GAG>CAG	p.E191Q	PGD_uc001ard.2_Missense_Mutation_p.E111Q|PGD_uc010oak.1_Missense_Mutation_p.E169Q|PGD_uc010oal.1_Missense_Mutation_p.E178Q	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	191		Proton donor (By similarity).			pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CAACGGGATAGAGTATGGGGA	0.582													0	0	0	0.024245	0	13	45										C	10471526	G	C	10471526	3	2	4	1	0	0	0	0	1	0	0	0	11787	943	33	1	597	1	PGD	1	10471526	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	9145805	10471526	238779095	2	423										
EIF4G3	8672	broad.mit.edu	37	chr1	21177865	21177865	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccgctgctcttcttgagactGattgtctagcaggtctttac	9	11	4	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:21177865G>C	uc001bec.2	-	23	3746	c.3490C>G	c.(3490-3492)CAG>GAG	p.Q1164E	EIF4G3_uc010odi.1_Missense_Mutation_p.Q768E|EIF4G3_uc010odj.1_Missense_Mutation_p.Q1163E|EIF4G3_uc009vpz.2_Missense_Mutation_p.Q884E|EIF4G3_uc001bed.2_Missense_Mutation_p.Q1164E|EIF4G3_uc001bef.2_Missense_Mutation_p.Q1200E|EIF4G3_uc001bee.2_Missense_Mutation_p.Q1170E	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1164					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTTGAGACTGATTGTCTAGC	0.522													0	0	0	0.013114	0	39	84										C	21177865	G	C	21177865	3	2	4	1	0	0	0	0	1	0	0	0	5038	1299	45	1	1307	1	EIF4G3	1	21177865	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	10706339	21177865	228072756	3	424										
ASAP3	55616	broad.mit.edu	37	chr1	23768756	23768756	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atctggctctccccggctttGagcagatactaggaggaggg	14	10	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:23768756G>C	uc001bha.2	-	7	718	c.594C>G	c.(592-594)CTC>CTG	p.L198L	ASAP3_uc010odz.1_Silent_p.L67L|ASAP3_uc010oea.1_Silent_p.L189L	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	198					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CCCCGGCTTTGAGCAGATACT	0.567													0	0	0	0.021553	0	5	14										C	23768756	G	C	23768756	2	2	4	1	0	0	0	0	0	0	0	1	1012	1277	45	1		1	ASAP3	1	23768756	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2590891	23768756	225481865	4	425										
ARID1A	8289	broad.mit.edu	37	chr1	27105793	27105793	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agccagcttcagagaatagtGaggagaagctgatcagtaag	13	6	2	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:27105793G>T	uc001bmv.1	+	20	5777	c.5404G>T	c.(5404-5406)GAG>TAG	p.E1802*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.E1585*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.E648*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.E130*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.E44*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1802					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGAGAATAGTGAGGAGAAGCT	0.438			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								1	0	2.23348e-06	0.028581	2.28993e-06	15	24										T	27105793	G	T	27105793	4	4	4	1	0	0	0	0	0	1	0	0	913	1291	45	3	5482	3	ARID1A	1	27105793	Nonsense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	3337037	27105793	222144828	5	426			1	2		3	3	1161	G		3.94982e-05
ARID1A	8289	broad.mit.edu	37	chr1	27106492	27106492	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cactaacttatgaaaaggagGaggaacaggaccaaggggtg	14	6	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:27106492G>A	uc001bmv.1	+	20	6476	c.6103G>A	c.(6103-6105)GAG>AAG	p.E2035K	ARID1A_uc001bmu.1_Missense_Mutation_p.E1818K|ARID1A_uc001bmx.1_Missense_Mutation_p.E881K|ARID1A_uc009vsm.1_Missense_Mutation_p.E363K|ARID1A_uc009vsn.1_Missense_Mutation_p.E277K	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2035					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGAAAAGGAGGAGGAACAGGA	0.557			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	49	69										A	27106492	G	A	27106492	3	1	4	1	0	0	0	0	1	0	0	0	913	1175	41	1	6181	1	ARID1A	1	27106492	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	699	27106492	222144129	6	427			1	2		3	3	1161	G		3.94982e-05
ARID1A	8289	broad.mit.edu	37	chr1	27106953	27106953	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gctcgtgccattgcagtgcaGaagggcagtatcggcaacct	13	11	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:27106953G>T	uc001bmv.1	+	20	6937	c.6564G>T	c.(6562-6564)CAG>CAT	p.Q2188H	ARID1A_uc001bmu.1_Missense_Mutation_p.Q1971H|ARID1A_uc001bmx.1_Missense_Mutation_p.Q1034H|ARID1A_uc009vsm.1_Missense_Mutation_p.Q516H|ARID1A_uc009vsn.1_Missense_Mutation_p.Q430H	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2188					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TTGCAGTGCAGAAGGGCAGTA	0.627			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								1	0	3.05275e-18	0.013114	3.2965e-18	41	106										T	27106953	G	T	27106953	3	4	4	1	0	0	0	0	1	0	0	0	913	933	33	3	6642	3	ARID1A	1	27106953	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	461	27106953	222143668	7	428			1	2		3	3	1161	G		3.94982e-05
AK2	204	broad.mit.edu	37	chr1	33490112	33490112	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccagaagccaccatggccctCagcatgtccccagtagctaa	8	16	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:33490112C>T	uc001bwp.1	-	2	192	c.150G>A	c.(148-150)CTG>CTA	p.L50L	uc001bwn.2_Intron|AK2_uc001bwo.1_Silent_p.L50L|AK2_uc010ohq.1_Silent_p.L50L|AK2_uc009vud.1_Intron|AK2_uc010ohr.1_Silent_p.L2L|AK2_uc001bwq.1_Silent_p.L2L	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	50	AMP (By similarity).				nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CCATGGCCCTCAGCATGTCCC	0.453													0	0	0	0.028581	0	16	29										T	33490112	C	T	33490112	2	4	4	1	0	0	0	0	0	0	0	1	440	813	29	1		1	AK2	1	33490112	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6383159	33490112	215760509	8	429										
KIAA0754	643314	broad.mit.edu	37	chr1	39878981	39878981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	caccccagaggagcccacctCcccagctgctgcagtgccca	9	20	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:39878981C>T	uc009vvt.1	+	1	3806	c.3044C>T	c.(3043-3045)TCC>TTC	p.S1015F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	879	Ala-rich.|1.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGCCCACCTCCCCAGCTGCT	0.697													0	0	0	0.024245	0	12	17										T	39878981	C	T	39878981	3	4	4	1	0	0	0	0	1	0	0	0	8192	855	30	1	3046	1	KIAA0754	1	39878981	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6388869	39878981	209371640	9	430										
MACF1	23499	broad.mit.edu	37	chr1	39910468	39910468	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agtgtagcacttttggagcaGaagtggcatgtggtcagcag	15	6	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:39910468G>T	uc010oiu.1	+	45	15026	c.14895G>T	c.(14893-14895)CAG>CAT	p.Q4965H	MACF1_uc010ois.1_Missense_Mutation_p.Q4463H	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTTGGAGCAGAAGTGGCATG	0.438													1	0	2.48696e-23	0.015359	2.74823e-23	30	36										T	39910468	G	T	39910468	3	4	4	1	0	0	0	0	1	0	0	0	9144	933	33	3	19842	3	MACF1	1	39910468	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	31487	39910468	209340153	10	431										
LEPRE1	64175	broad.mit.edu	37	chr1	43232529	43232529	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gctgcggtcccctcggcgaaGagcagatcaggcgtcaccat	13	14	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:43232529G>C	uc001chv.2	-	1	227	c.114C>G	c.(112-114)CTC>CTG	p.L38L	LEPRE1_uc001chw.2_Silent_p.L38L|LEPRE1_uc001chx.3_Silent_p.L38L|LEPRE1_uc001chy.3_Silent_p.L38L|LEPRE1_uc001chz.2_Silent_p.L38L|C1orf50_uc001cia.3_5'Flank	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	38	TPR 1.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCTCGGCGAAGAGCAGATCAG	0.711													0	0	0	0.027894	0	33	53										C	43232529	G	C	43232529	2	2	4	1	0	0	0	0	0	0	0	1	8729	929	33	1		1	LEPRE1	1	43232529	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	3322061	43232529	206018092	11	432										
CACHD1	57685	broad.mit.edu	37	chr1	65095063	65095063	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcagacaacctgaaatccaaCcctggaattaagtggcaata	8	10	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:65095063C>A	uc001dbo.1	+	5	495	c.390C>A	c.(388-390)AAC>AAA	p.N130K	CACHD1_uc001dbp.1_5'UTR|CACHD1_uc001dbq.1_5'UTR	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	181	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						TGAAATCCAACCCTGGAATTA	0.453													1	0	6.38683e-12	0.008361	6.81902e-12	26	52										A	65095063	C	A	65095063	3	1	4	1	0	0	0	0	1	0	0	0	2537	506	18	4	408	4	CACHD1	1	65095063	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	21862534	65095063	184155558	12	433										
ST6GALNAC3	256435	broad.mit.edu	37	chr1	77094406	77094406	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgccccatatgggggtcataGgtttatcactgaaaagaaag	11	7	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:77094406G>A	uc001dhh.2	+	5	996	c.833G>A	c.(832-834)AGG>AAG	p.R278K	ST6GALNAC3_uc010orh.1_Missense_Mutation_p.R177K	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	278	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						GGGGGTCATAGGTTTATCACT	0.378													0	0	0	0.00499	0	16	32										A	77094406	G	A	77094406	3	1	4	1	0	0	0	0	1	0	0	0	15224	1000	35	2	865	2	ST6GALNAC3	1	77094406	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	11999343	77094406	172156215	13	434										
TMEM56	148534	broad.mit.edu	37	chr1	95609471	95609471	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagaaatatggagatcaacaCaaaactgctcatcagtgtta	7	7	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:95609471C>G	uc001drb.2	+	2	305	c.14C>G	c.(13-15)ACA>AGA	p.T5R	RWDD3_uc001drd.3_Missense_Mutation_p.T5R|TMEM56_uc001drc.2_Missense_Mutation_p.T5R	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	5						integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		GAGATCAACACAAAACTGCTC	0.313													0	0	0	0.014323	0	17	16										G	95609471	C	G	95609471	3	3	4	1	0	0	0	0	1	0	0	0	16180	478	17	4	16	4	TMEM56	1	95609471	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	18515065	95609471	153641150	14	435										
PHTF1	10745	broad.mit.edu	37	chr1	114247322	114247322	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcagtgataaccatattttaAtattctccaccttcttaagt	4	9	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:114247322A>C	uc009wgp.1	-	13	2221	c.1769T>G	c.(1768-1770)ATT>AGT	p.I590S	PHTF1_uc001edn.2_Missense_Mutation_p.I590S|PHTF1_uc001edm.2_Missense_Mutation_p.I347S	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	590						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATATTTTAATATTCTCCAC	0.353													0	0	0	0.008291	0	10	25										C	114247322	A	C	114247322	3	2	4	1	0	0	0	0	1	0	0	0	11862	101	4	5	543	5	PHTF1	1	114247322	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	18637851	114247322	135003299	15	436										
CSDE1	7812	broad.mit.edu	37	chr1	115261332	115261332	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	caagcgattgaccaaccgatCaggtcgaggagctgcaacag	12	11	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:115261332C>T	uc001efk.2	-	19	2717	c.2251G>A	c.(2251-2253)GAT>AAT	p.D751N	NRAS_uc009wgu.2_5'Flank|CSDE1_uc001efi.2_Missense_Mutation_p.D797N|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.D720N|CSDE1_uc001efm.2_Missense_Mutation_p.D766N|CSDE1_uc009wgv.2_Missense_Mutation_p.D751N|CSDE1_uc001efn.2_Missense_Mutation_p.D720N	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	751					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACCAACCGATCAGGTCGAGGA	0.502													0	0	0	0.016723	0	12	31										T	115261332	C	T	115261332	3	4	4	1	0	0	0	0	1	0	0	0	3929	826	29	1	153	1	CSDE1	1	115261332	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1014010	115261332	133989289	16	437										
PTGFRN	5738	broad.mit.edu	37	chr1	117529499	117529499	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gggctcctgtcctgtctcatCgggtactgcagctcccactg	11	15	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:117529499C>T	uc001egv.1	+	9	2687	c.2550C>T	c.(2548-2550)ATC>ATT	p.I850I		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	850	Helical; (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		CCTGTCTCATCGGGTACTGCA	0.607													0	0	0	0.01441	0	53	77										T	117529499	C	T	117529499	2	4	4	1	0	0	0	0	0	0	0	1	12750	874	31	1		1	PTGFRN	1	117529499	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2268167	117529499	131721122	17	438										
CD5L	922	broad.mit.edu	37	chr1	157803159	157803159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggagggagagagggacttccCacagcccagttgcttgcata	14	10	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:157803159C>T	uc001frk.3	-	5	1005	c.862G>A	c.(862-864)GGG>AGG	p.G288R		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	288	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGGGACTTCCCACAGCCCAGT	0.587													0	0	0	0.013114	0	43	125										T	157803159	C	T	157803159	3	4	4	1	0	0	0	0	1	0	0	0	3027	594	21	2	189	2	CD5L	1	157803159	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	40273660	157803159	91447462	18	439										
CD1D	912	broad.mit.edu	37	chr1	158151257	158151257	+	Frame_Shift_Del	DEL	T	T	-													0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tctcccagtcccgcaaaggcTtttccccctccgctgcctcc							TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:158151257delT	uc001frr.2	+	3	573	c.74delT	c.(73-75)CTTfs	p.L25fs	CD1D_uc009wsr.1_Frame_Shift_Del_p.L25fs|CD1D_uc009wss.2_Frame_Shift_Del_p.L25fs|CD1D_uc009wst.1_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	25	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CCGCAAAGGCTTTTCCCCCTC	0.592																		7	868	---	---								-	158151257	T	-	158151257	7	5	4	1	0	1	0	1	0	0	0	0	2977	1609	56	0	80	0	CD1D	1	158151257	Frame_Shift_Del	DEL	T	TCGA-BL-A3JM-01A-12D-A21A-08	348098	158151257	91099364	19	440										
MAEL	84944	broad.mit.edu	37	chr1	166973535	166973535	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gggaactggccacctatctaCtgcaaggtaatttcaggtta	10	9	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:166973535C>T	uc001gdy.1	+	6	713	c.642C>T	c.(640-642)TAC>TAT	p.Y214Y	MAEL_uc001gdz.1_Silent_p.Y183Y|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	214					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						CACCTATCTACTGCAAGGTAA	0.343													0	0	0	0.00308	0	5	31										T	166973535	C	T	166973535	2	4	4	1	0	0	0	0	0	0	0	1	9154	576	20	2		2	MAEL	1	166973535	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	8822278	166973535	82277086	20	441										
FMO3	2328	broad.mit.edu	37	chr1	171085395	171085395	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	acatgatgaatgatattaatGagaaaatggagaaaaagcgc	10	3	0	5			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:171085395G>A	uc001ghi.2	+	8	1342	c.1231G>A	c.(1231-1233)GAG>AAG	p.E411K	FMO3_uc001ghh.2_Missense_Mutation_p.E411K|FMO3_uc010pmb.1_Missense_Mutation_p.E391K|FMO3_uc010pmc.1_Missense_Mutation_p.E348K	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	411					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGATATTAATGAGAAAATGGA	0.358													0	0	0	0.020292	0	11	23										A	171085395	G	A	171085395	3	1	4	1	0	0	0	0	1	0	0	0	5956	1291	45	1	1257	1	FMO3	1	171085395	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	4111860	171085395	78165226	21	442										
C1orf9	51430	broad.mit.edu	37	chr1	172558282	172558282	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atgtttcagtattgcaacctCtgagtggagaattggaaaat	10	5	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:172558282C>G	uc001giq.3	+	18	2357	c.2041C>G	c.(2041-2043)CTG>GTG	p.L681V	C1orf9_uc010pmm.1_Missense_Mutation_p.L681V|C1orf9_uc009wwd.2_Missense_Mutation_p.L637V|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	681					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		ATTGCAACCTCTGAGTGGAGA	0.408													0	0	0	0.007413	0	15	81										G	172558282	C	G	172558282	3	3	4	1	0	0	0	0	1	0	0	0	2067	912	32	1	2111	1	C1orf9	1	172558282	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1472887	172558282	76692339	22	443										
SLC9A11	284525	broad.mit.edu	37	chr1	173517647	173517647	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctcctgtatgtgctgagtggCattttgcaagatcatttgtc	10	8	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:173517647C>G	uc001giz.2	-	12	1765	c.1342G>C	c.(1342-1344)GCC>CCC	p.A448P	SLC9A11_uc009wwe.2_Missense_Mutation_p.A6P|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	448					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TGCTGAGTGGCATTTTGCAAG	0.363													0	0	0	0.006122	0	14	26										G	173517647	C	G	173517647	3	3	4	1	0	0	0	0	1	0	0	0	14711	710	25	4	2100	4	SLC9A11	1	173517647	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	959365	173517647	75732974	23	444										
CEP350	9857	broad.mit.edu	37	chr1	179989148	179989148	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcccacaagttcaccattctCaaccacagccttttgctgga	6	15	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:179989148C>T	uc001gnt.2	+	12	2622	c.2239C>T	c.(2239-2241)CAA>TAA	p.Q747*	CEP350_uc009wxl.2_Nonsense_Mutation_p.Q746*|CEP350_uc001gnu.2_Nonsense_Mutation_p.Q581*	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	747						centrosome|nucleus|spindle				ovary(4)	4						TCACCATTCTCAACCACAGCC	0.383													0	0	0	0.01441	0	45	92										T	179989148	C	T	179989148	4	4	4	1	0	0	0	0	0	1	0	0	3254	827	29	1	2281	1	CEP350	1	179989148	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6471501	179989148	69261473	24	445										
CEP350	9857	broad.mit.edu	37	chr1	180063622	180063622	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cttcttggtgatgaccaaaaGaaagtaacaccccaagacct	7	11	1	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:180063622G>A	uc001gnt.2	+	34	8765	c.8382G>A	c.(8380-8382)AAG>AAA	p.K2794K	CEP350_uc009wxl.2_Silent_p.K2793K|CEP350_uc001gnv.2_Silent_p.K929K|CEP350_uc001gnw.1_Silent_p.K551K|CEP350_uc001gnx.1_Silent_p.K551K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2794						centrosome|nucleus|spindle				ovary(4)	4						ATGACCAAAAGAAAGTAACAC	0.388													0	0	0	0.014758	0	3	8										A	180063622	G	A	180063622	2	1	4	1	0	0	0	0	0	0	0	1	3254	933	33	1		1	CEP350	1	180063622	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	74474	180063622	69186999	25	446										
CDC73	79577	broad.mit.edu	37	chr1	193121533	193121533	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cggaaggcttcaaaattgacActatgggaacctaccatggt	10	9	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:193121533A>G	uc001gtb.2	+	10	1174	c.931A>G	c.(931-933)ACT>GCT	p.T311A		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	311					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						CAAAATTGACACTATGGGAAC	0.333									Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				0	0	0	0.028581	0	12	11										G	193121533	A	G	193121533	3	3	4	1	0	0	0	0	1	0	0	0	3085	159	6	5	969	5	CDC73	1	193121533	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	13057911	193121533	56129088	26	447										
FAM71A	149647	broad.mit.edu	37	chr1	212798352	212798352	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atatattcaagtatgcaccgAtatttgagagcgactttatc	7	7	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:212798352A>T	uc001hjk.2	+	1	537	c.133A>T	c.(133-135)ATA>TTA	p.I45L	uc010pth.1_Intron	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	45										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		GTATGCACCGATATTTGAGAG	0.512													0	0	0	0.01441	0	44	114										T	212798352	A	T	212798352	3	4	4	1	0	0	0	0	1	0	0	0	5607	333	12	5	135	5	FAM71A	1	212798352	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	19676819	212798352	36452269	27	448										
OBSCN	84033	broad.mit.edu	37	chr1	228400372	228400372	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcgcaggagaacttcgtgctCaagatcctcttctgcaagca	10	12	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:228400372C>G	uc009xez.1	+	2	932	c.888C>G	c.(886-888)CTC>CTG	p.L296L	OBSCN_uc001hsn.2_Silent_p.L296L|uc001hsm.1_RNA	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	296	Ig-like 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACTTCGTGCTCAAGATCCTCT	0.657													0	0	0	0.01441	0	42	110										G	228400372	C	G	228400372	2	3	4	1	0	0	0	0	0	0	0	1	10812	813	29	1		1	OBSCN	1	228400372	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	15602020	228400372	20850249	28	449										
GALNT2	2590	broad.mit.edu	37	chr1	230398367	230398367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atggatgaatacaaaaatttCtattatgcagcagtgccttc	7	7	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:230398367C>G	uc010pwa.1	+	12	1257	c.1185C>G	c.(1183-1185)TTC>TTG	p.F395L	GALNT2_uc010pvy.1_Missense_Mutation_p.F357L|GALNT2_uc010pvz.1_RNA|GALNT2_uc001htu.2_Missense_Mutation_p.F7L	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	395	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ACAAAAATTTCTATTATGCAG	0.448													0	0	0	0.01441	0	65	146										G	230398367	C	G	230398367	3	3	4	1	0	0	0	0	1	0	0	0	6213	912	32	1	1231	1	GALNT2	1	230398367	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1997995	230398367	18852254	29	450										
OR2G3	81469	broad.mit.edu	37	chr1	247768909	247768909	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgggattgggcaatgagagtTccctaatggatttcatcctt	11	7	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:247768909T>A	uc010pyz.1	+	1	22	c.22T>A	c.(22-24)TCC>ACC	p.S8T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CAATGAGAGTTCCCTAATGGA	0.468													0	0	0	0.010818	0	23	37										A	247768909	T	A	247768909	3	1	4	1	0	0	0	0	1	0	0	0	10999	1783	62	5	24	5	OR2G3	1	247768909	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	17370542	247768909	1481712	30	451										
ABCG8	64241	broad.mit.edu	37	chr2	44101118	44101118	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aacgtcattctggatgtcatCtccaaatgtgagtgtggccc	10	10	4	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:44101118C>T	uc002rtq.2	+	9	1494	c.1404C>T	c.(1402-1404)ATC>ATT	p.I468I	ABCG8_uc010yoa.1_Silent_p.I467I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	468	Helical; Name=2; (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGGATGTCATCTCCAAATGTG	0.542													0	0	0	0.01441	0	62	97										T	44101118	C	T	44101118	2	4	4	1	0	0	0	0	0	0	0	1	72	903	32	1		1	ABCG8	2	44101118	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		44101118	199098255	31	452										
SLC4A5	57835	broad.mit.edu	37	chr2	74462335	74462335	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggaaaagtcagccaccagggCccggacctgcagacaggaga	14	12	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:74462335C>A	uc002sko.1	-	17	2328	c.2326G>T	c.(2326-2328)GCC>TCC	p.A776S	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.A776S|SLC4A5_uc010ffc.1_Missense_Mutation_p.A776S|SLC4A5_uc002skp.1_Intron|SLC4A5_uc002sks.1_Intron	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	776	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						GCCACCAGGGCCCGGACCTGC	0.532													1	0	1.96292e-10	0.010504	2.08011e-10	20	10										A	74462335	C	A	74462335	3	1	4	1	0	0	0	0	1	0	0	0	14657	739	26	4	1127	4	SLC4A5	2	74462335	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	30361217	74462335	168737038	32	453										
FABP1	2168	broad.mit.edu	37	chr2	88425824	88425824	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttctgcacgatttccgacacCcccttgatatccttcccctt	4	17	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:88425824C>A	uc002sst.1	-	2	153	c.111G>T	c.(109-111)GGG>GGT	p.G37G	FABP1_uc002ssu.2_Silent_p.G37G	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	37					organ morphogenesis						0						TTTCCGACACCCCCTTGATAT	0.532													1	0	2.09629e-50	0.01441	2.36249e-50	104	197										A	88425824	C	A	88425824	2	1	4	1	0	0	0	0	0	0	0	1	5355	610	22	4		4	FABP1	2	88425824	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	13963489	88425824	154773549	33	454										
DPP10	57628	broad.mit.edu	37	chr2	116066873	116066873	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gggaattgctattgctctgcTggtgattttagttgtatgct	12	5	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:116066873T>A	uc002tla.1	+	2	576	c.119T>A	c.(118-120)CTG>CAG	p.L40Q	DPP10_uc002tlb.1_5'UTR|DPP10_uc002tlc.1_Missense_Mutation_p.L36Q|DPP10_uc002tle.2_Missense_Mutation_p.L44Q|DPP10_uc002tlf.1_Missense_Mutation_p.L33Q	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	40	Mediates effects on KCND2.|Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATTGCTCTGCTGGTGATTTTA	0.408													0	0	0	0.021022	0	28	28										A	116066873	T	A	116066873	3	1	4	1	0	0	0	0	1	0	0	0	4727	1580	55	5	296	5	DPP10	2	116066873	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	27641049	116066873	127132500	34	455										
TTN	7273	broad.mit.edu	37	chr2	179397839	179397839	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	acagcagcttctctcagagcCtctttagctacctgtgtcag	8	13	4	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:179397839C>G	uc010zfg.1	-	307	96023	c.95799G>C	c.(95797-95799)GAG>GAC	p.E31933D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25628D|TTN_uc010zfi.1_Missense_Mutation_p.E25561D|TTN_uc010zfj.1_Missense_Mutation_p.E25436D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32860							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCAGAGCCTCTTTAGCTA	0.428													0	0	0	0.007835	0	37	60										G	179397839	C	G	179397839	3	3	4	1	0	0	0	0	1	0	0	0	16732	680	24	4	4496	4	TTN	2	179397839	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	63330966	179397839	63801534	35	456										
TNS1	7145	broad.mit.edu	37	chr2	218699859	218699859	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggaggttccctccatctcctCgaaggcctccttgtagctgt	10	14	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:218699859C>T	uc002vgt.2	-	19	3258	c.2860G>A	c.(2860-2862)GAG>AAG	p.E954K	TNS1_uc002vgr.2_Missense_Mutation_p.E954K|TNS1_uc002vgs.2_Missense_Mutation_p.E954K|TNS1_uc010zjv.1_Missense_Mutation_p.E954K	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	954						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCCATCTCCTCGAAGGCCTCC	0.572													0	0	0	0.013114	0	38	13										T	218699859	C	T	218699859	3	4	4	1	0	0	0	0	1	0	0	0	16340	893	31	1	2407	1	TNS1	2	218699859	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	39302020	218699859	24499514	36	457										
ALPP	250	broad.mit.edu	37	chr2	233245162	233245162	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtgtggaaccgcactgagctCatgcaggcttccctggaccc	12	14	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:233245162C>G	uc002vsq.2	+	7	990	c.825C>G	c.(823-825)CTC>CTG	p.L275L	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	275						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCACTGAGCTCATGCAGGCTT	0.647													0	0	0	0.01441	0	65	117										G	233245162	C	G	233245162	2	3	4	1	0	0	0	0	0	0	0	1	548	813	29	1		1	ALPP	2	233245162	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	14545303	233245162	9954211	37	458										
C3orf31	132001	broad.mit.edu	37	chr3	11851124	11851124	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gttttgggcaatgtcatcagCtgagtgaactgtccttctgg	12	8	3	2	rs140106641	byFrequency	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:11851124C>T	uc003bwh.2	-	6	983	c.741G>A	c.(739-741)CAG>CAA	p.Q247Q	C3orf31_uc003bwj.2_Silent_p.Q247Q|C3orf31_uc003bwi.2_RNA|C3orf31_uc011auo.1_Silent_p.Q247Q	NM_138807	NP_620162	Q96BW9	MMP37_HUMAN	MMP37-like protein, mitochondrial precursor	247					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane					0						ATGTCATCAGCTGAGTGAACT	0.398													0	0	0	0.027356	0	18	24										T	11851124	C	T	11851124	2	4	4	1	0	0	0	0	0	0	0	1	2221	796	28	2		2	C3orf31	3	11851124	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		11851124	186171306	38	459										
ARPP21	10777	broad.mit.edu	37	chr3	35731587	35731587	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttgcagggacaggatgatacTtttgaaaatggagcaggaaa	13	4	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:35731587T>G	uc003cgb.2	+	8	764	c.500T>G	c.(499-501)CTT>CGT	p.L167R	ARPP21_uc003cga.2_Missense_Mutation_p.L167R|ARPP21_uc011axy.1_Missense_Mutation_p.L167R|ARPP21_uc003cgf.2_Missense_Mutation_p.L3R	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	167	R3H.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AGGATGATACTTTTGAAAATG	0.294													0	0	0	0.004482	0	9	21										G	35731587	T	G	35731587	3	3	4	1	0	0	0	0	1	0	0	0	978	1609	56	5	535	5	ARPP21	3	35731587	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	23880463	35731587	162290843	39	460										
CTNNB1	1499	broad.mit.edu	37	chr3	41266113	41266113	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cctggactctggaatccattCtggtgccactaccacagctc	8	15	2	0	rs121913403		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:41266113C>G	uc010hia.1	+	4	266	c.110C>G	c.(109-111)TCT>TGT	p.S37C	CTNNB1_uc003ckp.2_Missense_Mutation_p.S37C|CTNNB1_uc003ckq.2_Missense_Mutation_p.S37C|CTNNB1_uc003ckr.2_Missense_Mutation_p.S37C|CTNNB1_uc011azf.1_Missense_Mutation_p.S30C|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	37			S -> C (in PTR, hepatoblastoma and ovarian cancer).|SG -> W (in hepatocellular carcinoma).|S -> F (in PTR).|S -> A (in MDB and hepatocellular carcinoma; enhances transactivation of target genes).|S -> Y (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S37F(147)|p.S37C(124)|p.A5_A80del(63)|p.S37A(59)|p.S37Y(23)|p.S37P(16)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.V22_G80>NNNNN(1)|p.GIHS34?(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.V22_T102del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.P16_K133del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.G34_S37del(1)|p.I35_S37>T(1)|p.I35_K170del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.S37S(1)|p.S37T(1)|p.V22_S71>A(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.V22_Y64del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.Y30_T40del(1)|p.M1_T42del(1)|p.S37_G38>W(1)|p.A5_Q143>E(1)|p.I35_G38del(1)|p.H36_E53>L(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.S37_A39>S(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.I35_T41del(1)|p.W25_A80del(1)|p.A20_Q72del(1)|p.A20_S111del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGAATCCATTCTGGTGCCACT	0.498	S37F(HUTU80_SMALL_INTESTINE)|S37C(SNU398_LIVER)|S37C(JHUEM2_ENDOMETRIUM)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.008871	0	19	20										G	41266113	C	G	41266113	3	3	4	1	0	0	0	0	1	0	0	0	4016	913	32	1	116	1	CTNNB1	3	41266113	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	5534526	41266113	156756317	40	461										
MAP4	4134	broad.mit.edu	37	chr3	47913544	47913544	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aggctggggcagaagctggcTtggatggtgaggcccgcttc	18	9	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:47913544T>A	uc003csb.2	-	11	2895	c.2369A>T	c.(2368-2370)AAG>ATG	p.K790M	MAP4_uc003csc.3_Missense_Mutation_p.K790M|MAP4_uc003crw.2_5'Flank|MAP4_uc003crx.2_Missense_Mutation_p.K50M|MAP4_uc011bbe.1_Missense_Mutation_p.K541M|MAP4_uc003cry.2_Missense_Mutation_p.K525M|MAP4_uc003csa.3_Missense_Mutation_p.K525M|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.K525M	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	790					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AGAAGCTGGCTTGGATGGTGA	0.562													0	0	0	0.01441	0	98	150										A	47913544	T	A	47913544	3	1	4	1	0	0	0	0	1	0	0	0	9258	1609	56	5	1276	5	MAP4	3	47913544	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	6647431	47913544	150108886	41	462										
DUSP7	1849	broad.mit.edu	37	chr3	52090150	52090150	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	actcgaagagctcgtgcggcCggcagtcgagcagcagcaag	15	12	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52090150C>A	uc003dct.2	-	1	312	c.233G>T	c.(232-234)CGG>CTG	p.R78L	DUSP7_uc010hma.2_Missense_Mutation_p.R78L	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	78	Rhodanese.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTCGTGCGGCCGGCAGTCGAG	0.627													1	0	2.0095e-06	0.001984	2.06774e-06	4	15										A	52090150	C	A	52090150	3	1	4	1	0	0	0	0	1	0	0	0	4830	652	23	4	1038	4	DUSP7	3	52090150	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	4176606	52090150	145932280	42	463										
POC1A	25886	broad.mit.edu	37	chr3	52179937	52179937	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtccatgccggcagcggcaaTgcacgtcccactggggtgga	15	13	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52179937T>C	uc003dcu.2	-	6	922	c.604A>G	c.(604-606)ATT>GTT	p.I202V	POC1A_uc003dcv.2_Missense_Mutation_p.I164V|POC1A_uc003dcw.2_Missense_Mutation_p.I202V	NM_015426	NP_056241	Q8NBT0	POC1A_HUMAN	WD repeat domain 51A isoform 1	202	WD 5.					centriole|microtubule basal body					0						GCAGCGGCAATGCACGTCCCA	0.592													0	0	0	0.015359	0	28	52										C	52179937	T	C	52179937	3	2	4	1	0	0	0	0	1	0	0	0	12175	1464	51	5	643	5	POC1A	3	52179937	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	89787	52179937	145842493	43	464										
TLR9	54106	broad.mit.edu	37	chr3	52256622	52256622	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agggtgcgcaggtgagccacGaagctgaagttgtggcccac	16	10	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52256622G>A	uc003dda.1	-	2	2344	c.1710C>T	c.(1708-1710)TTC>TTT	p.F570F	TLR9_uc003ddb.2_Silent_p.F667F	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	570	LRR 18.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GGTGAGCCACGAAGCTGAAGT	0.642													0	0	0	0.01892	0	24	23										A	52256622	G	A	52256622	2	1	4	1	0	0	0	0	0	0	0	1	15955	1049	37	1		1	TLR9	3	52256622	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	76685	52256622	145765808	44	465										
TMEM110	375346	broad.mit.edu	37	chr3	52883817	52883817	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagcatattaccatattcgcCgaagcgcagggactcccact	8	14	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52883817C>A	uc003dge.2	-	4	499	c.418G>T	c.(418-420)GGC>TGC	p.G140C	TMEM110_uc003dgc.3_Missense_Mutation_p.G140C	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	140						integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		CCATATTCGCCGAAGCGCAGG	0.627													1	0	9.4991e-31	0.01441	1.0621e-30	58	14										A	52883817	C	A	52883817	3	1	4	1	0	0	0	0	1	0	0	0	16024	652	23	4	486	4	TMEM110	3	52883817	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	627195	52883817	145138613	45	466										
HESX1	8820	broad.mit.edu	37	chr3	57232284	57232284	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tagaaactgtgattctctatGggaccttttcagttttgcac	8	8	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:57232284G>T	uc003din.3	-	4	833	c.499C>A	c.(499-501)CAT>AAT	p.H167N		NM_003865	NP_003856	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	167	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		GATTCTCTATGGGACCTTTTC	0.299													1	0	0.00024832	0.009096	0.000251867	3	21										T	57232284	G	T	57232284	3	4	4	1	0	0	0	0	1	0	0	0	7072	1348	47	4	62	4	HESX1	3	57232284	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	4348467	57232284	140790146	46	467										
FLNB	2317	broad.mit.edu	37	chr3	58062849	58062849	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctgatcctccactactccatCtccatgcccgtgtgggagga	9	15	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:58062849C>T	uc003djj.2	+	2	534	c.369C>T	c.(367-369)ATC>ATT	p.I123I	FLNB_uc010hne.2_Silent_p.I123I|FLNB_uc003djk.2_Silent_p.I123I|FLNB_uc010hnf.2_Silent_p.I123I|FLNB_uc003djl.2_5'Flank|FLNB_uc003djm.2_5'Flank	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	123	Actin-binding.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACTACTCCATCTCCATGCCCG	0.552													0	0	0	0.007835	0	37	60										T	58062849	C	T	58062849	2	4	4	1	0	0	0	0	0	0	0	1	5934	903	32	1		1	FLNB	3	58062849	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	830565	58062849	139959581	47	468										
C3orf64	285203	broad.mit.edu	37	chr3	69031975	69031975	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tacttacctatacttgtaatCaacaatctggacttcaaatg	4	9	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:69031975C>T	uc003dnl.2	-	15	1606	c.1201G>A	c.(1201-1203)GAT>AAT	p.D401N	C3orf64_uc003dnj.2_Missense_Mutation_p.D80N|C3orf64_uc003dnk.2_Missense_Mutation_p.D317N|C3orf64_uc011bfw.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	401						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		TACTTGTAATCAACAATCTGG	0.388													0	0	0	0.00308	0	6	17										T	69031975	C	T	69031975	3	4	4	1	0	0	0	0	1	0	0	0	2240	826	29	1	398	1	C3orf64	3	69031975	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	10969126	69031975	128990455	48	469										
OR5AC2	81050	broad.mit.edu	37	chr3	97806241	97806241	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gccttttcagatgcttgtacTtcaacctctataacccctag	5	13	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:97806241T>G	uc011bgs.1	+	1	225	c.225T>G	c.(223-225)ACT>ACG	p.T75T		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATGCTTGTACTTCAACCTCTA	0.428													0	0	0	0.01441	0	46	125										G	97806241	T	G	97806241	2	3	4	1	0	0	0	0	0	0	0	1	11141	1596	56	5		5	OR5AC2	3	97806241	Silent	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	28774266	97806241	100216189	49	470										
ALCAM	214	broad.mit.edu	37	chr3	105269058	105269058	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttacattaacttgcacagcaGaaaaccaactggagagaaca	7	9	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:105269058G>A	uc003dvx.2	+	12	2002	c.1462G>A	c.(1462-1464)GAA>AAA	p.E488K	ALCAM_uc003dvw.1_Missense_Mutation_p.E488K|ALCAM_uc003dvy.2_Missense_Mutation_p.E488K|ALCAM_uc010hpp.2_Missense_Mutation_p.E210K|ALCAM_uc003dvz.2_Missense_Mutation_p.E122K	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	488	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						TTGCACAGCAGAAAACCAACT	0.333													0	0	0	0.027356	0	25	19										A	105269058	G	A	105269058	3	1	4	1	0	0	0	0	1	0	0	0	487	943	33	1	1508	1	ALCAM	3	105269058	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	7462817	105269058	92753372	50	471										
ACPP	55	broad.mit.edu	37	chr3	132056364	132056364	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgagagtgagactttgaaatCagaggaattccagaagaggc	13	5	1	6			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:132056364C>T	uc010htp.2	+	5	611	c.521C>T	c.(520-522)TCA>TTA	p.S174L	ACPP_uc003eon.3_Intron|ACPP_uc003eop.3_Missense_Mutation_p.S174L	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	174						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						ACTTTGAAATCAGAGGAATTC	0.398													0	0	0	0.01441	0	53	10										T	132056364	C	T	132056364	3	4	4	1	0	0	0	0	1	0	0	0	167	838	29	1	539	1	ACPP	3	132056364	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	26787306	132056364	65966066	51	472										
ETV5	2119	broad.mit.edu	37	chr3	185766491	185766491	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tccatgtccaggaggtaagcGgggctgtcttcaaagtgggt	15	8	2	0	rs151057501		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:185766491G>A	uc003fpz.2	-	13	1717	c.1470C>T	c.(1468-1470)CCC>CCT	p.P490P	ETV5_uc003fpy.2_Silent_p.P532P	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	490					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			GGAGGTAAGCGGGGCTGTCTT	0.597			T	TMPRSS2|SCL45A3	Prostate 								0	0	0	0.023175	0	33	70										A	185766491	G	A	185766491	2	1	4	1	0	0	0	0	0	0	0	1	5282	1103	39	2		2	ETV5	3	185766491	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	53710127	185766491	12255939	52	473										
ATP13A3	79572	broad.mit.edu	37	chr3	194147857	194147857	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgctgtttgacccaaaaaaaAcccaaagattgaaatccaat	5	9	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:194147857A>C	uc003fty.3	-	28	3474	c.3072T>G	c.(3070-3072)GGT>GGG	p.G1024G	ATP13A3_uc003ftx.3_5'Flank	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1024					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CCCAAAAAAAACCCAAAGATT	0.388													0	0	0	0.013114	0	40	10										C	194147857	A	C	194147857	2	2	4	1	0	0	0	0	0	0	0	1	1125	30	2	5		5	ATP13A3	3	194147857	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	8381366	194147857	3874573	53	474										
PROM1	8842	broad.mit.edu	37	chr4	16077403	16077403	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agctttatgggagtcttgggTctcataatttgttgcaggca	12	6	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:16077403T>G	uc003goo.2	-	1	339	c.127A>C	c.(127-129)ACC>CCC	p.T43P	PROM1_uc003gor.2_Missense_Mutation_p.T43P|PROM1_uc003gos.2_Missense_Mutation_p.T43P|PROM1_uc003got.2_Missense_Mutation_p.T43P|PROM1_uc003gou.2_Missense_Mutation_p.T43P|PROM1_uc003gop.2_Missense_Mutation_p.T43P|PROM1_uc003goq.3_Missense_Mutation_p.T43P|PROM1_uc010iec.1_5'UTR	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	43	Extracellular (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						GAGTCTTGGGTCTCATAATTT	0.488													0	0	0	0.007413	0	17	0										G	16077403	T	G	16077403	3	3	4	1	0	0	0	0	1	0	0	0	12555	1667	58	5	2574	5	PROM1	4	16077403	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08		16077403	175076873	54	475										
PPARGC1A	10891	broad.mit.edu	37	chr4	23815314	23815314	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gggttttgccaaggtttaccTtgaagaggatctactgcctg	12	8	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:23815314T>G	uc003gqs.2	-	8	1912	c.1792A>C	c.(1792-1794)AGA>CGA	p.R598R	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	598	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				AAGGTTTACCTTGAAGAGGAT	0.398													0	0	0	0.028581	0	11	22										G	23815314	T	G	23815314	2	3	4	1	0	0	0	0	0	0	0	1	12300	1623	56	5		5	PPARGC1A	4	23815314	Silent	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	7737911	23815314	167338962	55	476										
RBM47	54502	broad.mit.edu	37	chr4	40438583	40438583	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tatatataccacgaccagcaGaatatcccccgaggtaggaa	8	11	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:40438583G>A	uc003gvc.2	-	5	1915	c.1205C>T	c.(1204-1206)TCT>TTT	p.S402F	RBM47_uc003gvd.2_Intron|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.S364F	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	402						nucleus	nucleotide binding|RNA binding			breast(3)	3						ACGACCAGCAGAATATCCCCC	0.507													0	0	0	0.01441	0	79	171										A	40438583	G	A	40438583	3	1	4	1	0	0	0	0	1	0	0	0	13141	942	33	1	588	1	RBM47	4	40438583	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	16623269	40438583	150715693	56	477										
RBM47	54502	broad.mit.edu	37	chr4	40440104	40440104	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cgctccacgcagccggggttGaactggccgaagctcttctt	12	14	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:40440104G>A	uc003gvc.2	-	4	1517	c.807C>T	c.(805-807)TTC>TTT	p.F269F	RBM47_uc003gvd.2_Silent_p.F269F|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.F231F|RBM47_uc003gvg.1_Silent_p.F269F	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	269	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(3)	3						AGCCGGGGTTGAACTGGCCGA	0.592													0	0	0	0.009718	0	41	52										A	40440104	G	A	40440104	2	1	4	1	0	0	0	0	0	0	0	1	13141	1281	45	1		1	RBM47	4	40440104	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1521	40440104	150714172	57	478										
KIT	3815	broad.mit.edu	37	chr4	55564535	55564535	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cgctgtcctctcacagacccAgaagtgaccaattattccct	6	15	1	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:55564535A>T	uc010igr.2	+	3	510	c.423A>T	c.(421-423)CCA>CCT	p.P141P	KIT_uc010igs.2_Silent_p.P141P	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	141	Extracellular (Potential).|Ig-like C2-type 2.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TCACAGACCCAGAAGTGACCA	0.512		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	0.024245	0	12	29										T	55564535	A	T	55564535	2	4	4	1	0	0	0	0	0	0	0	1	8329	175	7	5		5	KIT	4	55564535	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	15124431	55564535	135589741	58	479										
KIAA1211	57482	broad.mit.edu	37	chr4	57181275	57181275	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gagacagaccatgccccggcCctacacgttccaggtgtcct	10	16	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:57181275C>T	uc003hbk.2	+	8	1998	c.1607C>T	c.(1606-1608)CCC>CTC	p.P536L	KIAA1211_uc010iha.2_Missense_Mutation_p.P529L|KIAA1211_uc011bzz.1_Missense_Mutation_p.P446L|KIAA1211_uc003hbm.1_Missense_Mutation_p.P422L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	536										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					ATGCCCCGGCCCTACACGTTC	0.642													0	0	0	0.008871	0	15	6										T	57181275	C	T	57181275	3	4	4	1	0	0	0	0	1	0	0	0	8215	623	22	2	1625	2	KIAA1211	4	57181275	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1616740	57181275	133973001	59	480										
DSPP	1834	broad.mit.edu	37	chr4	88534106	88534106	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggagcagatgaggatgaagaCgagggttctggtgatgatga	18	3	1	7			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:88534106C>T	uc003hqu.2	+	4	888	c.768C>T	c.(766-768)GAC>GAT	p.D256D		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	256					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AGGATGAAGACGAGGGTTCTG	0.507													0	0	0	0.024245	0	13	27										T	88534106	C	T	88534106	2	4	4	1	0	0	0	0	0	0	0	1	4782	535	19	2		2	DSPP	4	88534106	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	31352831	88534106	102620170	60	481										
PRDM5	11107	broad.mit.edu	37	chr4	121616352	121616352	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cttatggcaaaactggcattCtgccaggggacgattgggat	13	8	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:121616352C>T	uc003idn.2	-	16	2057	c.1807G>A	c.(1807-1809)GAA>AAA	p.E603K	PRDM5_uc003ido.2_Missense_Mutation_p.E572K|PRDM5_uc010ine.2_3'UTR	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	603	C2H2-type 16.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						AACTGGCATTCTGCCAGGGGA	0.428													0	0	0	0.024334	0	24	37										T	121616352	C	T	121616352	3	4	4	1	0	0	0	0	1	0	0	0	12460	922	32	1	89	1	PRDM5	4	121616352	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	33082246	121616352	69537924	61	482										
FSTL5	56884	broad.mit.edu	37	chr4	162421208	162421208	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cactaggcttaatgtgcctcTgaaattcacattctatgggt	8	9	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:162421208T>C	uc003iqh.2	-	12	1854	c.1418A>G	c.(1417-1419)CAG>CGG	p.Q473R	FSTL5_uc003iqi.2_Missense_Mutation_p.Q472R|FSTL5_uc010iqv.2_Missense_Mutation_p.Q463R	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	473						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AATGTGCCTCTGAAATTCACA	0.338													0	0	0	0.00308	0	7	2										C	162421208	T	C	162421208	3	2	4	1	0	0	0	0	1	0	0	0	6080	1580	55	5	1145	5	FSTL5	4	162421208	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	40804856	162421208	28733068	62	483										
IRX2	153572	broad.mit.edu	37	chr5	2749625	2749625	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cggggcccaggtcatcttgtTctccttcttgaggcgccggc	13	14	4	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:2749625T>C	uc003jda.2	-	2	768	c.526A>G	c.(526-528)AAC>GAC	p.N176D	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Missense_Mutation_p.N176D	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	176						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GTCATCTTGTTCTCCTTCTTG	0.597													0	0	0	0.025465	0	31	91										C	2749625	T	C	2749625	3	2	4	1	0	0	0	0	1	0	0	0	7844	1783	62	5	901	5	IRX2	5	2749625	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08		2749625	178165635	63	484										
TRIO	7204	broad.mit.edu	37	chr5	14507245	14507245	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctttagggctgaccagggtcGcctcctggactgcgtggtgc	15	12	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:14507245G>A	uc003jff.2	+	56	8633	c.8627G>A	c.(8626-8628)CGC>CAC	p.R2876H	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2876	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.R2876C(2)		skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GACCAGGGTCGCCTCCTGGAC	0.567													0	0	0	0.00499	0	15	53										A	14507245	G	A	14507245	3	1	4	1	0	0	0	0	1	0	0	0	16549	1087	38	2	8849	2	TRIO	5	14507245	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	11757620	14507245	166408015	64	485										
FBXL7	23194	broad.mit.edu	37	chr5	15500819	15500819	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atggcaaacagtacggcagtGagggtgagtgggccgcccgt	17	9	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:15500819G>A	uc003jfn.1	+	1	515	c.34G>A	c.(34-36)GAG>AAG	p.E12K		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	12					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GTACGGCAGTGAGGGTGAGTG	0.692													0	0	0	0.01441	0	100	280										A	15500819	G	A	15500819	3	1	4	1	0	0	0	0	1	0	0	0	5724	1291	45	1	36	1	FBXL7	5	15500819	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	993574	15500819	165414441	65	486										
MYO10	4651	broad.mit.edu	37	chr5	16694540	16694540	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cgctgtcgttttcaaagtacAtcagcttggactggcggagg	13	9	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:16694540A>G	uc003jft.3	-	27	4208	c.3740T>C	c.(3739-3741)ATG>ACG	p.M1247T	MYO10_uc011cnc.1_Missense_Mutation_p.M126T|MYO10_uc011cnd.1_Missense_Mutation_p.M604T|MYO10_uc011cne.1_Missense_Mutation_p.M604T|MYO10_uc010itx.2_Missense_Mutation_p.M870T	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1247	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TTCAAAGTACATCAGCTTGGA	0.562													0	0	0	0.01441	0	58	134										G	16694540	A	G	16694540	3	3	4	1	0	0	0	0	1	0	0	0	10062	217	8	5	2496	5	MYO10	5	16694540	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	1193721	16694540	164220720	66	487										
CDC20B	166979	broad.mit.edu	37	chr5	54410097	54410097	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcagctgcagcagaaaacacCcgggtctggtctggactcaa	11	12	4	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:54410097C>T	uc003jpo.1	-	12	1684	c.1509G>A	c.(1507-1509)CGG>CGA	p.R503R	CDC20B_uc003jpn.1_Silent_p.R499R|CDC20B_uc010ivu.1_Silent_p.R461R	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	503	WD 7.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			cagaaaacacccgggtctggt	0.199													0	0	0	0.013726	0	35	74										T	54410097	C	T	54410097	2	4	4	1	0	0	0	0	0	0	0	1	3060	610	22	2		2	CDC20B	5	54410097	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	37715557	54410097	126505163	67	488										
CMYA5	202333	broad.mit.edu	37	chr5	79030171	79030171	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcacttatgagagagaatttGcctttggaacaatcaaaatc	7	7	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:79030171G>T	uc003kgc.2	+	2	5655	c.5583G>T	c.(5581-5583)TTG>TTT	p.L1861F		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1861						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAGAGAATTTGCCTTTGGAAC	0.343													1	0	2.17888e-05	0.006214	2.2259e-05	8	34										T	79030171	G	T	79030171	3	4	4	1	0	0	0	0	1	0	0	0	3590	1310	46	4	5589	4	CMYA5	5	79030171	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	24620074	79030171	101885089	68	489										
WDR36	134430	broad.mit.edu	37	chr5	110441021	110441021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tggaactcttcagtcattttCcacggtacatgaaaaattca	6	9	4	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:110441021C>T	uc003kpd.2	+	10	1340	c.1223C>T	c.(1222-1224)TCC>TTC	p.S408F	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	408	WD 5.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CAGTCATTTTCCACGGTACAT	0.348													0	0	0	0.001984	0	6	19										T	110441021	C	T	110441021	3	4	4	1	0	0	0	0	1	0	0	0	17287	855	30	1	1261	1	WDR36	5	110441021	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	31410850	110441021	70474239	69	490										
GPX3	2878	broad.mit.edu	37	chr5	150407000	150407000	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	catttctcaacaggtatgtcCgaccaggtggaggctttgtc	11	10	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:150407000C>T	uc011dcm.1	+	5	584	c.367C>T	c.(367-369)CGA>TGA	p.R123*	GPX3_uc003ltc.2_RNA|GPX3_uc003ltd.2_RNA	NM_002084	NP_002075	P22352	GPX3_HUMAN	glutathione peroxidase 3 precursor	123					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CAGGTATGTCCGACCAGGTGG	0.493													0	0	0	0.024334	0	23	59										T	150407000	C	T	150407000	4	4	4	1	0	0	0	0	0	1	0	0	6741	644	23	2	381	2	GPX3	5	150407000	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	39965979	150407000	30508260	70	491										
GPX3	2878	broad.mit.edu	37	chr5	150407039	150407039	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tccctaatttccagctctttGagaaaggggatgtcaatgga	10	8	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:150407039G>C	uc011dcm.1	+	5	623	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	GPX3_uc003ltc.2_RNA|GPX3_uc003ltd.2_RNA	NM_002084	NP_002075	P22352	GPX3_HUMAN	glutathione peroxidase 3 precursor	136					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CCAGCTCTTTGAGAAAGGGGA	0.527													0	0	0	0.020292	0	14	64										C	150407039	G	C	150407039	3	2	4	1	0	0	0	0	1	0	0	0	6741	1291	45	1	420	1	GPX3	5	150407039	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	39	150407039	30508221	71	492										
NOP16	51491	broad.mit.edu	37	chr5	175811366	175811366	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atagtaattcttctcatcacGggccatggcctaagaggaga	10	9	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:175811366G>A	uc011dfl.1	-	5	403	c.403C>T	c.(403-405)CGT>TGT	p.R135C	NOP16_uc003med.2_Intron|NOP16_uc003mee.2_Intron	NM_016391	NP_057475	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein homolog	135						nucleolus				ovary(1)|central_nervous_system(1)	2						TTCTCATCACGGGCCATGGCC	0.458													0	0	0	0.01892	0	19	50										A	175811366	G	A	175811366	3	1	4	1	0	0	0	0	1	0	0	0	10537	1116	39	2	136	2	NOP16	5	175811366	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	25404327	175811366	5103894	72	493										
HIST1H1E	3008	broad.mit.edu	37	chr6	26156945	26156945	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggttccttcaaactcaacaaGaaggcggcctctggggaagc	12	11	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:26156945G>T	uc003ngq.2	+	1	387	c.327G>T	c.(325-327)AAG>AAT	p.K109N	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	109	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						AACTCAACAAGAAGGCGGCCT	0.622													1	0	0.00010058	0.013537	0.000102382	13	28										T	26156945	G	T	26156945	3	4	4	1	0	0	0	0	1	0	0	0	7126	933	33	3	329	3	HIST1H1E	6	26156945	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		26156945	144958122	73	494										
PBX2	5089	broad.mit.edu	37	chr6	32157485	32157485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cactcacttggcctgggcctCgtccaggctctggtcggtga	13	14	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:32157485C>T	uc003oav.1	-	1	479	c.208G>A	c.(208-210)GAG>AAG	p.E70K	PBX2_uc003oaw.2_Missense_Mutation_p.E70K	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	70							transcription factor binding			ovary(1)	1						GCCTGGGCCTCGTCCAGGCTC	0.647													0	0	0	0.00874	0	31	34										T	32157485	C	T	32157485	3	4	4	1	0	0	0	0	1	0	0	0	11493	893	31	1	1120	1	PBX2	6	32157485	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6000540	32157485	138957582	74	495										
BRD2	6046	broad.mit.edu	37	chr6	32944130	32944130	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gagatacctaccactgtcctCaacattccccacccatcagt	4	17	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:32944130C>T	uc003ocn.3	+	6	2415	c.714C>T	c.(712-714)CTC>CTT	p.L238L	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.L238L|BRD2_uc003ocp.3_Silent_p.L118L|BRD2_uc010juh.2_Silent_p.L238L	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	238					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						CCACTGTCCTCAACATTCCCC	0.567													0	0	0	0.010771	0	37	72										T	32944130	C	T	32944130	2	4	4	1	0	0	0	0	0	0	0	1	1502	813	29	1		1	BRD2	6	32944130	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	786645	32944130	138170937	75	496										
GLP1R	2740	broad.mit.edu	37	chr6	39047367	39047367	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagtccacgctgacactcatCcccctgctggggactcatga	9	15	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:39047367C>A	uc003ooj.3	+	11	1131	c.1071C>A	c.(1069-1071)ATC>ATA	p.I357I	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	357	Helical; Name=6; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	TGACACTCATCCCCCTGCTGG	0.567													1	0	9.78306e-22	0.009535	1.06861e-21	24	55										A	39047367	C	A	39047367	2	1	4	1	0	0	0	0	0	0	0	1	6452	845	30	3		3	GLP1R	6	39047367	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6103237	39047367	132067700	76	497										
PGC	5225	broad.mit.edu	37	chr6	41708252	41708252	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcaatgccaatctgccagtaGagttcctgggtgacaggcgc	12	11	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:41708252G>C	uc003ora.1	-	6	793	c.744C>G	c.(742-744)CTC>CTG	p.L248L		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	248					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TCTGCCAGTAGAGTTCCTGGG	0.617													0	0	0	0.01441	0	64	87										C	41708252	G	C	41708252	2	2	4	1	0	0	0	0	0	0	0	1	11785	929	33	1		1	PGC	6	41708252	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2660885	41708252	129406815	77	498										
CCND3	896	broad.mit.edu	37	chr6	42016405	42016405	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccgaacagagccagtctccaCccctgcagtggcgaagtgtt	11	14	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:42016405C>T	uc003orp.2	-	1	206	c.-211G>A	c.(-213--209)GGGTG>GGATG		CCND3_uc011duk.1_Translation_Start_Site|CCND3_uc011dum.1_Translation_Start_Site|TAF8_uc003orr.2_5'Flank|TAF8_uc003ors.2_5'Flank|TAF8_uc003ort.2_5'Flank|TAF8_uc003oru.1_5'Flank|TAF8_uc003orv.1_5'Flank|TAF8_uc011dun.1_5'Flank	NM_001136017	NP_001129489	P30281	CCND3_HUMAN	cyclin D3 isoform 1						cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCAGTCTCCACCCCTGCAGTG	0.672			T	IGH@	MM								0	0	0	0.006122	0	14	22										T	42016405	C	T	42016405	1	4	4	1	0	0	0	0	0	0	0	0	2918	522	18	2		2	CCND3	6	42016405	Translation_Start_Site	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	308153	42016405	129098662	78	499										
ABCC10	89845	broad.mit.edu	37	chr6	43400684	43400684	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gggcaggagccactaagccaCggcctgctctatgctctggg	14	13	2	0	rs145760020		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:43400684C>T	uc003ouy.1	+	3	1181	c.966C>T	c.(964-966)CAC>CAT	p.H322H	ABCC10_uc003ouz.1_Silent_p.H279H|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	322	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CACTAAGCCACGGCCTGCTCT	0.587													0	0	0	0.025465	0	34	57										T	43400684	C	T	43400684	2	4	4	1	0	0	0	0	0	0	0	1	50	535	19	2		2	ABCC10	6	43400684	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1384279	43400684	127714383	79	500										
SLC25A27	9481	broad.mit.edu	37	chr6	46623750	46623750	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agctttggcaaggagtgacaCccgccatttacagacacgta	10	11	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:46623750C>T	uc003oyh.2	+	2	528	c.277C>T	c.(277-279)CCC>TCC	p.P93S	SLC25A27_uc011dwb.1_Missense_Mutation_p.P93S|SLC25A27_uc003oyg.2_Missense_Mutation_p.P93S|SLC25A27_uc011dwc.1_5'UTR|SLC25A27_uc003oyi.2_5'Flank	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	93	Solcar 1.|Helical; Name=2; (Potential).				generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			AGGAGTGACACCCGCCATTTA	0.453													0	0	0	0.013114	0	35	72										T	46623750	C	T	46623750	3	4	4	1	0	0	0	0	1	0	0	0	14490	507	18	2	283	2	SLC25A27	6	46623750	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	3223066	46623750	124491317	80	501										
GSTA5	221357	broad.mit.edu	37	chr6	52698951	52698951	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcacttactttttcaaaggcAgggaagtagcgattttttat	8	6	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:52698951A>C	uc003pba.1	-	5	472	c.402T>G	c.(400-402)CCT>CCG	p.P134P		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	134	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	TTTCAAAGGCAGGGAAGTAGC	0.423													0	0	0	0.01441	0	52	92										C	52698951	A	C	52698951	2	2	4	1	0	0	0	0	0	0	0	1	6834	175	7	5		5	GSTA5	6	52698951	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	6075201	52698951	118416116	81	502										
MDN1	23195	broad.mit.edu	37	chr6	90448114	90448114	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gatgatctgaattaaatcttCacggcttgtgctttgagggc	11	7	3	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:90448114C>T	uc003pnn.1	-	33	4770	c.4654G>A	c.(4654-4656)GAA>AAA	p.E1552K		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1552					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ATTAAATCTTCACGGCTTGTG	0.393													0	0	0	0.024334	0	25	37										T	90448114	C	T	90448114	3	4	4	1	0	0	0	0	1	0	0	0	9415	835	29	1	12416	1	MDN1	6	90448114	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	37749163	90448114	80666953	82	503										
CLVS2	134829	broad.mit.edu	37	chr6	123319295	123319295	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttctagtcctttttgctgccAattgggatcagagcaggtaa	10	8	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:123319295A>T	uc003pzi.1	+	2	1242	c.373A>T	c.(373-375)AAT>TAT	p.N125Y		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	125	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TTTTGCTGCCAATTGGGATCA	0.483													0	0	0	0.010504	0	19	31										T	123319295	A	T	123319295	3	4	4	1	0	0	0	0	1	0	0	0	3572	130	5	5	375	5	CLVS2	6	123319295	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	32871181	123319295	47795772	83	504										
PHACTR2	9749	broad.mit.edu	37	chr6	143929448	143929448	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcctcgccactcctgagacaTggacaacgccggtgggtaaa	12	13	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:143929448T>C	uc003qjq.3	+	1	132	c.2T>C	c.(1-3)ATG>ACG	p.M1T	PHACTR2_uc010khh.2_Missense_Mutation_p.M1T	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	1							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TCCTGAGACATGGACAACGCC	0.542													0	0	0	0.016522	0	18	31										C	143929448	T	C	143929448	3	2	4	1	0	0	0	0	1	0	0	0	11810	1464	51	5	4	5	PHACTR2	6	143929448	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	20610153	143929448	27185619	84	505										
GRM1	2911	broad.mit.edu	37	chr6	146720833	146720833	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aaggcaggggcagggaatgcCaagtgagttatctgacctgt	15	7	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:146720833C>T	uc010khw.1	+	8	3128	c.2658C>T	c.(2656-2658)GCC>GCT	p.A886A	GRM1_uc010khv.1_Silent_p.A886A|GRM1_uc003qll.2_Silent_p.A886A|GRM1_uc011edz.1_Silent_p.A886A|GRM1_uc011eea.1_Silent_p.A886A	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	886	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAGGGAATGCCAAGTGAGTTA	0.343													0	0	0	0.021553	0	6	7										T	146720833	C	T	146720833	2	4	4	1	0	0	0	0	0	0	0	1	6796	581	21	2		2	GRM1	6	146720833	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2791385	146720833	24394234	85	506										
SYNE1	23345	broad.mit.edu	37	chr6	152674462	152674462	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgtcaatcttggtagccacaTtcttgaagtttttatgagta	8	6	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:152674462T>A	uc010kiw.2	-	69	11791	c.11189A>T	c.(11188-11190)AAT>ATT	p.N3730I	SYNE1_uc003qot.3_Missense_Mutation_p.N3715I|SYNE1_uc003qou.3_Missense_Mutation_p.N3730I|SYNE1_uc010kja.1_Missense_Mutation_p.N435I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3730	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTAGCCACATTCTTGAAGTT	0.398										HNSCC(10;0.0054)			0	0	0	0.014758	0	5	103										A	152674462	T	A	152674462	3	1	4	1	0	0	0	0	1	0	0	0	15442	1493	52	5	15589	5	SYNE1	6	152674462	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	5953629	152674462	18440605	86	507										
PNLDC1	154197	broad.mit.edu	37	chr6	160225085	160225085	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccttccaggcttccagtgttCagtttttgaatcagtatggc	9	10	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:160225085C>T	uc003qsx.1	+	5	475	c.304C>T	c.(304-306)CAG>TAG	p.Q102*	PNLDC1_uc003qsy.1_Nonsense_Mutation_p.Q113*	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	102	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTCCAGTGTTCAGTTTTTGAA	0.343													0	0	0	0.01441	0	53	107										T	160225085	C	T	160225085	4	4	4	1	0	0	0	0	0	1	0	0	12148	827	29	1	318	1	PNLDC1	6	160225085	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	7550623	160225085	10889982	87	508										
CCR6	1235	broad.mit.edu	37	chr6	167550264	167550264	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtcatcatctccagctcaacTtttgtcttcaaccaaaaata	3	12	6	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:167550264T>G	uc003qvl.2	+	13	3022	c.546T>G	c.(544-546)ACT>ACG	p.T182T	CCR6_uc010kkm.2_Silent_p.T182T|CCR6_uc003qvn.3_Silent_p.T182T|CCR6_uc003qvm.3_Silent_p.T182T	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	182	Extracellular (Potential).			T -> S (in Ref. 4; AAB06949).	cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CCAGCTCAACTTTTGTCTTCA	0.517													0	0	0	0.021022	0	35	40										G	167550264	T	G	167550264	2	3	4	1	0	0	0	0	0	0	0	1	2945	1596	56	5		5	CCR6	6	167550264	Silent	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	7325179	167550264	3564803	88	509										
SKAP2	8935	broad.mit.edu	37	chr7	26709771	26709771	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	taggcaccaagccaatggctCccttcatttctcctacccac	5	17	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:26709771C>T	uc003syc.2	-	12	1321	c.1028G>A	c.(1027-1029)GGA>GAA	p.G343E	SKAP2_uc011jzi.1_Missense_Mutation_p.G171E|SKAP2_uc011jzj.1_Missense_Mutation_p.G328E	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	343	SH3.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						GCCAATGGCTCCCTTCATTTC	0.363													0	0	0	0.01892	0	19	28										T	26709771	C	T	26709771	3	4	4	1	0	0	0	0	1	0	0	0	14356	855	30	1	55	1	SKAP2	7	26709771	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		26709771	132428892	89	510										
HOXA10	3206	broad.mit.edu	37	chr7	27213894	27213894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttgttgtgggataatttggcGaagggagcagatagcccttt	14	5	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:27213894G>A	uc011jzm.1	-	1	62	c.32C>T	c.(31-33)TCG>TTG	p.S11L	HOXA10_uc003syw.3_Intron	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	11					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ATAATTTGGCGAAGGGAGCAG	0.557													0	0	0	0.010771	0	46	86										A	27213894	G	A	27213894	3	1	4	1	0	0	0	0	1	0	0	0	7289	1059	37	1	1208	1	HOXA10	7	27213894	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	504123	27213894	131924769	90	511										
SEMA3A	10371	broad.mit.edu	37	chr7	83636800	83636800	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atacatacacacggctgatcCcttgaaaatgttactgaaca	6	10	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:83636800C>A	uc003uhz.2	-	10	1324	c.1009G>T	c.(1009-1011)GGA>TGA	p.G337*		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	337	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACGGCTGATCCCTTGAAAATG	0.388													1	0	4.7546e-09	0.028581	4.98268e-09	15	19										A	83636800	C	A	83636800	4	1	4	1	0	0	0	0	0	1	0	0	14024	632	22	4	1338	4	SEMA3A	7	83636800	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	56422906	83636800	75501863	91	512										
ZAN	7455	broad.mit.edu	37	chr7	100364700	100364700	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gatggcgccttgcaccacttCatgggcacctgcacctatgt	10	14	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:100364700C>A	uc003uwj.2	+	25	4845	c.4680C>A	c.(4678-4680)TTC>TTA	p.F1560L	ZAN_uc003uwk.2_Missense_Mutation_p.F1560L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.F137L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1560	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCACCACTTCATGGGCACCT	0.607													1	0	4.25531e-23	0.01441	4.68414e-23	46	86										A	100364700	C	A	100364700	3	1	4	1	0	0	0	0	1	0	0	0	17510	825	29	3	4774	3	ZAN	7	100364700	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	16727900	100364700	58773963	92	513										
MOGAT3	346606	broad.mit.edu	37	chr7	100841559	100841559	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctgaatacagggcctcgtgcGcaccccccaccatgatgacc	9	17	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:100841559G>A	uc003uyc.2	-	5	748	c.581C>T	c.(580-582)GCG>GTG	p.A194V	MOGAT3_uc010lhr.2_Missense_Mutation_p.A194V	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	194					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GGCCTCGTGCGCACCCCCCAC	0.677													0	0	0	0.01441	0	70	23										A	100841559	G	A	100841559	3	1	4	1	0	0	0	0	1	0	0	0	9696	1087	38	2	456	2	MOGAT3	7	100841559	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	476859	100841559	58297104	93	514										
PAX4	5078	broad.mit.edu	37	chr7	127253582	127253582	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcaggatactgcccacgctgGaactctgcggagatcgagtc	12	12	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:127253582G>T	uc010lld.1	-	5	749	c.543C>A	c.(541-543)TTC>TTA	p.F181L	PAX4_uc003vmf.2_Missense_Mutation_p.F179L|PAX4_uc003vmg.1_Missense_Mutation_p.F181L|PAX4_uc003vmh.2_Missense_Mutation_p.F179L	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	189	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCCACGCTGGAACTCTGCGG	0.587													1	0	4.96729e-08	0.008871	5.12986e-08	20	57										T	127253582	G	T	127253582	3	4	4	1	0	0	0	0	1	0	0	0	11481	1165	41	3	508	3	PAX4	7	127253582	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	26412023	127253582	31885081	94	515										
CNTNAP2	26047	broad.mit.edu	37	chr7	147600709	147600709	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gccaacgagaagcactactaCtggggaggctctgggcctgg	15	11	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:147600709C>T	uc003weu.1	+	14	2667	c.2151C>T	c.(2149-2151)TAC>TAT	p.Y717Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	717	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGCACTACTACTGGGGAGGCT	0.512										HNSCC(39;0.1)			0	0	0	0.004482	0	6	21										T	147600709	C	T	147600709	2	4	4	1	0	0	0	0	0	0	0	1	3647	576	20	2		2	CNTNAP2	7	147600709	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	20347127	147600709	11537954	95	516										
ARHGEF10	9639	broad.mit.edu	37	chr8	1841803	1841803	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tacgtagatgctcttaagagGattttggaggtacttaagtg	12	4	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:1841803G>A	uc003wpr.2	+	12	1429	c.1251G>A	c.(1249-1251)AGG>AGA	p.R417R	ARHGEF10_uc003wpq.1_Silent_p.R442R|ARHGEF10_uc003wps.2_Silent_p.R379R|ARHGEF10_uc003wpt.2_Silent_p.R293R|ARHGEF10_uc003wpv.2_Silent_p.R150R|ARHGEF10_uc010lre.2_Silent_p.R97R	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	442	DH.				centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CTCTTAAGAGGATTTTGGAGG	0.313													0	0	0	0.024245	0	13	42										A	1841803	G	A	1841803	2	1	4	1	0	0	0	0	0	0	0	1	894	1165	41	1		1	ARHGEF10	8	1841803	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		1841803	144522219	96	517										
LPL	4023	broad.mit.edu	37	chr8	19811640	19811640	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcccttttaaggcctcgatcCagctggacctaactttgagt	8	12	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:19811640C>T	uc003wzk.3	+	5	921	c.551C>T	c.(550-552)CCA>CTA	p.P184L		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	184			P -> R (in LPL deficiency; Nijmegen; loss of activity).		fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	GGCCTCGATCCAGCTGGACCT	0.453													0	0	0	0.008871	0	19	55										T	19811640	C	T	19811640	3	4	4	1	0	0	0	0	1	0	0	0	8921	594	21	2	569	2	LPL	8	19811640	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	17969837	19811640	126552382	97	518										
CDCA2	157313	broad.mit.edu	37	chr8	25364307	25364307	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atgaaccaaaagctggaactGacagtcctgtttcttgtgct	9	9	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:25364307G>A	uc003xep.1	+	15	2604	c.2125G>A	c.(2125-2127)GAC>AAC	p.D709N	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.D694N|CDCA2_uc003xer.1_Missense_Mutation_p.D372N	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	709					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AGCTGGAACTGACAGTCCTGT	0.373													0	0	0	0.00308	0	6	12										A	25364307	G	A	25364307	3	1	4	1	0	0	0	0	1	0	0	0	3086	1290	45	1	2179	1	CDCA2	8	25364307	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	5552667	25364307	120999715	98	519										
DUSP26	78986	broad.mit.edu	37	chr8	33451114	33451114	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctggaagtggatgctcatgtCaaaggctggcgagtcgtggg	17	7	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:33451114C>T	uc003xjp.2	-	3	706	c.373G>A	c.(373-375)GAC>AAC	p.D125N	DUSP26_uc003xjq.2_Missense_Mutation_p.D125N	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	125	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		ATGCTCATGTCAAAGGCTGGC	0.642													0	0	0	0.007835	0	32	94										T	33451114	C	T	33451114	3	4	4	1	0	0	0	0	1	0	0	0	4823	826	29	1	270	1	DUSP26	8	33451114	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	8086807	33451114	112912908	99	520										
RP1	6101	broad.mit.edu	37	chr8	55539332	55539332	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cccatacaaattctggaaaaAtaagtaattttgttatggaa	6	5	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:55539332A>G	uc003xsd.1	+	4	3038	c.2890A>G	c.(2890-2892)ATA>GTA	p.I964V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	964					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTGGAAAAATAAGTAATTT	0.328													0	0	0	0.007291	0	29	22										G	55539332	A	G	55539332	3	3	4	1	0	0	0	0	1	0	0	0	13532	101	4	5	2900	5	RP1	8	55539332	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	22088218	55539332	90824690	100	521										
PLAG1	5324	broad.mit.edu	37	chr8	57079893	57079893	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggcatgcaaggccaagtgacGtttaaatccaagcttggtat	11	8	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:57079893G>A	uc003xsq.3	-	3	863	c.412C>T	c.(412-414)CGT>TGT	p.R138C	PLAG1_uc003xsr.3_Missense_Mutation_p.R138C|PLAG1_uc010lyi.2_Missense_Mutation_p.R138C|PLAG1_uc010lyj.2_Missense_Mutation_p.R56C	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	138	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.|C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GCCAAGTGACGTTTAAATCCA	0.448			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								0	0	0	0.010729	0	9	30										A	57079893	G	A	57079893	3	1	4	1	0	0	0	0	1	0	0	0	12018	1145	40	2	1094	2	PLAG1	8	57079893	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1540561	57079893	89284129	101	522										
ZFHX4	79776	broad.mit.edu	37	chr8	77764201	77764201	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctcctgatttaatctctgctCaacctgcacatcacccacca	3	17	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:77764201C>G	uc003yav.2	+	10	5296	c.4909C>G	c.(4909-4911)CAA>GAA	p.Q1637E	ZFHX4_uc003yau.1_Missense_Mutation_p.Q1682E|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q1637E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1637						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATCTCTGCTCAACCTGCACA	0.403										HNSCC(33;0.089)			0	0	0	0.008291	0	11	43										G	77764201	C	G	77764201	3	3	4	1	0	0	0	0	1	0	0	0	17632	827	29	1	5078	1	ZFHX4	8	77764201	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	20684308	77764201	68599821	102	523										
PLEKHF2	79666	broad.mit.edu	37	chr8	96166422	96166422	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagttgtgcaggaaaaagccCaaagcaaggcagtttttctt	10	7	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:96166422C>G	uc003yhn.1	+	2	397	c.150C>G	c.(148-150)CCC>CCG	p.P50P		NM_024613	NP_078889	Q9H8W4	PKHF2_HUMAN	phafin 2	50	PH.					transport vesicle	metal ion binding|protein binding			ovary(2)	2	Breast(36;3.18e-05)					GGAAAAAGCCCAAAGCAAGGC	0.358													0	0	0	0.007413	0	17	63										G	96166422	C	G	96166422	2	3	4	1	0	0	0	0	0	0	0	1	12067	581	21	4		4	PLEKHF2	8	96166422	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	18402221	96166422	50197600	103	524										
GDF6	392255	broad.mit.edu	37	chr8	97157377	97157377	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tccggccgaagcccagactcCgcaggtccgggggcggcggt	17	15	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:97157377C>T	uc003yhp.2	-	2	882	c.782G>A	c.(781-783)CGG>CAG	p.R261Q		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	261					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GCCCAGACTCCGCAGGTCCGG	0.736													0	0	0	0.009096	0	3	16										T	97157377	C	T	97157377	3	4	4	1	0	0	0	0	1	0	0	0	6317	652	23	2	589	2	GDF6	8	97157377	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	990955	97157377	49206645	104	525										
GDF6	392255	broad.mit.edu	37	chr8	97172829	97172829	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccagctcggcggacgacgagGaggatgagatggaagcctgc	17	10	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:97172829G>C	uc003yhp.2	-	1	192	c.92C>G	c.(91-93)TCC>TGC	p.S31C		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	31	Poly-Ser.				activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GGACGACGAGGAGGATGAGAT	0.647													0	0	0	0.01441	0	49	155										C	97172829	G	C	97172829	3	2	4	1	0	0	0	0	1	0	0	0	6317	1174	41	1	1283	1	GDF6	8	97172829	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	15452	97172829	49191193	105	526										
SYBU	55638	broad.mit.edu	37	chr8	110588178	110588178	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggcctctacccggtgacactCctcctcaatccagtcctctc	6	19	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:110588178C>G	uc003ynj.3	-	7	1112	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	SYBU_uc003yni.3_Missense_Mutation_p.E314Q|SYBU_uc003ynk.3_Missense_Mutation_p.E198Q|SYBU_uc010mco.2_Missense_Mutation_p.E316Q|SYBU_uc003ynl.3_Missense_Mutation_p.E316Q|SYBU_uc010mcp.2_Missense_Mutation_p.E317Q|SYBU_uc010mcq.2_Missense_Mutation_p.E317Q|SYBU_uc003yno.3_Missense_Mutation_p.E198Q|SYBU_uc010mcr.2_Missense_Mutation_p.E317Q|SYBU_uc003ynm.3_Missense_Mutation_p.E316Q|SYBU_uc003ynn.3_Missense_Mutation_p.E316Q|SYBU_uc010mcs.2_Missense_Mutation_p.E198Q|SYBU_uc010mct.2_Missense_Mutation_p.E317Q|SYBU_uc010mcu.2_Missense_Mutation_p.E316Q|SYBU_uc003ynp.3_Missense_Mutation_p.E249Q|SYBU_uc010mcv.2_Missense_Mutation_p.E317Q|SYBU_uc003ynh.3_Missense_Mutation_p.E111Q|SYBU_uc011lhw.1_Missense_Mutation_p.E187Q	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	317	Sufficient for interaction with STX1A.|Potential.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						CGGTGACACTCCTCCTCAATC	0.502													0	0	0	0.024334	0	26	73										G	110588178	C	G	110588178	3	3	4	1	0	0	0	0	1	0	0	0	15424	864	30	1	1046	1	SYBU	8	110588178	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	13415349	110588178	35775844	106	527										
CSMD3	114788	broad.mit.edu	37	chr8	113318249	113318249	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cacataccaacacagcgaggGgtcttgttatgattgctcca	9	11	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:113318249G>T	uc003ynu.2	-	51	8217	c.8058C>A	c.(8056-8058)ACC>ACA	p.T2686T	CSMD3_uc003yns.2_Silent_p.T1888T|CSMD3_uc003ynt.2_Silent_p.T2646T|CSMD3_uc011lhx.1_Silent_p.T2582T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2686	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACAGCGAGGGGTCTTGTTAT	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	1.08114e-33	0.01441	1.21361e-33	38	109										T	113318249	G	T	113318249	2	4	4	1	0	0	0	0	0	0	0	1	3946	1219	43	4		4	CSMD3	8	113318249	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2730071	113318249	33045773	107	528										
PLEC	5339	broad.mit.edu	37	chr8	145049425	145049425	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cacccccgctgcgccggctcCgctgcgttttcccaaggttc	10	19	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:145049425C>T	uc003zaj.2	-	2	162	c.113G>A	c.(112-114)CGG>CAG	p.R38Q	PLEC_uc003zah.2_5'Flank	NM_000445	NP_000436	Q15149	PLEC_HUMAN	plectin isoform 1c	141	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCGCCGGCTCCGCTGCGTTTT	0.667											OREG0019050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	84	73										T	145049425	C	T	145049425	3	4	4	1	0	0	0	0	1	0	0	0	12052	652	23	2	14770	2	PLEC	8	145049425	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	31731176	145049425	1314597	108	529										
PTPRD	5789	broad.mit.edu	37	chr9	8460469	8460469	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aaagaccactgcaaggacagGacctacaacccagatcaagc	8	13	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:8460469G>A	uc003zkk.2	-	32	4528	c.3817C>T	c.(3817-3819)CCT>TCT	p.P1273S	PTPRD_uc003zkp.2_Missense_Mutation_p.P862S|PTPRD_uc003zkq.2_Missense_Mutation_p.P862S|PTPRD_uc003zkr.2_Missense_Mutation_p.P857S|PTPRD_uc003zks.2_Missense_Mutation_p.P852S|PTPRD_uc003zkl.2_Missense_Mutation_p.P1264S|PTPRD_uc003zkm.2_Missense_Mutation_p.P1260S|PTPRD_uc003zkn.2_Missense_Mutation_p.P862S|PTPRD_uc003zko.2_Missense_Mutation_p.P859S	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1273	Helical; (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCAAGGACAGGACCTACAACC	0.463										TSP Lung(15;0.13)			0	0	0	0.009718	0	39	42										A	8460469	G	A	8460469	3	1	4	1	0	0	0	0	1	0	0	0	12799	1174	41	1	2042	1	PTPRD	9	8460469	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		8460469	132752962	109	530										
PTPRD	5789	broad.mit.edu	37	chr9	8465602	8465602	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gaaggacatcaaagtgagcgGcaatatatggctttaattca	10	6	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:8465602G>A	uc003zkk.2	-	31	4289	c.3578C>T	c.(3577-3579)GCC>GTC	p.A1193V	PTPRD_uc003zkp.2_Missense_Mutation_p.A782V|PTPRD_uc003zkq.2_Missense_Mutation_p.A782V|PTPRD_uc003zkr.2_Missense_Mutation_p.A777V|PTPRD_uc003zks.2_Missense_Mutation_p.A772V|PTPRD_uc003zkl.2_Missense_Mutation_p.A1184V|PTPRD_uc003zkm.2_Missense_Mutation_p.A1180V|PTPRD_uc003zkn.2_Missense_Mutation_p.A782V|PTPRD_uc003zko.2_Missense_Mutation_p.A779V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1193	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AAAGTGAGCGGCAATATATGG	0.428										TSP Lung(15;0.13)			0	0	0	0.009535	0	28	79										A	8465602	G	A	8465602	3	1	4	1	0	0	0	0	1	0	0	0	12799	1203	42	2	2285	2	PTPRD	9	8465602	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	5133	8465602	132747829	110	531										
FREM1	158326	broad.mit.edu	37	chr9	14859231	14859231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctccacgaggttcttctggtCgaggctccccgagaaccatc	10	15	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:14859231C>T	uc003zlm.2	-	4	1171	c.581G>A	c.(580-582)CGA>CAA	p.R194Q	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	194					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCTTCTGGTCGAGGCTCCCC	0.502													0	0	0	0.013726	0	31	41										T	14859231	C	T	14859231	3	4	4	1	0	0	0	0	1	0	0	0	6044	884	31	1	6144	1	FREM1	9	14859231	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6393629	14859231	126354200	111	532										
MLLT3	4300	broad.mit.edu	37	chr9	20414153	20414153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tttgggtttcttagaggattCtttggaagatttgttgtgat	12	2	2	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:20414153C>G	uc003zoe.2	-	5	950	c.691G>C	c.(691-693)GAA>CAA	p.E231Q	MLLT3_uc011lne.1_Missense_Mutation_p.E199Q|MLLT3_uc011lnf.1_Missense_Mutation_p.E228Q|MLLT3_uc003zof.2_Missense_Mutation_p.E32Q	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TTAGAGGATTCTTTGGAAGAT	0.378			T	MLL	ALL								0	0	0	0.01441	0	40	129										G	20414153	C	G	20414153	3	3	4	1	0	0	0	0	1	0	0	0	9628	922	32	1	1043	1	MLLT3	9	20414153	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	5554922	20414153	120799278	112	533										
APTX	54840	broad.mit.edu	37	chr9	32986023	32986023	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccttgactccagtggcccagGgattcctaaaaaaaaaacaa	7	11	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:32986023G>A	uc003zrm.2	-	4	686	c.489C>T	c.(487-489)TCC>TCT	p.S163S	APTX_uc010mjm.2_RNA|APTX_uc003zrj.2_Silent_p.S75S|APTX_uc011lns.1_5'UTR|APTX_uc003zrl.2_5'UTR|APTX_uc003zrn.2_Silent_p.S75S|APTX_uc003zro.2_Silent_p.S163S|APTX_uc003zrp.2_Silent_p.S75S|APTX_uc003zrq.2_Silent_p.S75S|APTX_uc003zrr.2_Silent_p.S109S|APTX_uc003zrs.2_Silent_p.S163S|APTX_uc003zrt.2_Silent_p.S75S|APTX_uc003zru.2_Silent_p.S109S|APTX_uc003zrv.2_Silent_p.S177S|APTX_uc003zrw.2_Silent_p.S91S|APTX_uc003zrx.2_Silent_p.S163S|APTX_uc003zry.2_Silent_p.S163S|APTX_uc003zrz.2_5'UTR|APTX_uc003zsa.1_Silent_p.S109S|APTX_uc003zsb.1_RNA|APTX_uc003zsc.1_RNA	NM_175072	NP_778242	Q7Z2E3	APTX_HUMAN	aprataxin isoform c	177					cell death|double-strand break repair|regulation of protein stability|response to hydrogen peroxide|single strand break repair	chromatin|nucleolus|nucleoplasm	chromatin binding|damaged DNA binding|DNA 5'-adenosine monophosphate hydrolase activity|double-stranded DNA binding|double-stranded RNA binding|phosphoglycolate phosphatase activity|phosphoprotein binding|polynucleotide 3'-phosphatase activity|protein N-terminus binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0302)	GBM - Glioblastoma multiforme(74;0.105)		AGTGGCCCAGGGATTCCTaaa	0.299								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.008291	0	10	44										A	32986023	G	A	32986023	2	1	4	1	0	0	0	0	0	0	0	1	820	1219	43	2		2	APTX	9	32986023	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	12571870	32986023	108227408	113	534										
OR1L3	26735	broad.mit.edu	37	chr9	125438220	125438220	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagctatactgtcaaggaccGaatagcaacaatcaactaca	6	11	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:125438220G>A	uc011lzb.1	+	1	812	c.812G>A	c.(811-813)CGA>CAA	p.R271Q		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTCAAGGACCGAATAGCAACA	0.408													0	0	0	0.006214	0	8	21										A	125438220	G	A	125438220	3	1	4	1	0	0	0	0	1	0	0	0	10964	1058	37	1	814	1	OR1L3	9	125438220	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	92452197	125438220	15775211	114	535										
RPL12	6136	broad.mit.edu	37	chr9	130210620	130210620	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gttgtcctgctcttaccagaGagttctctggctaaggatcg	11	10	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:130210620G>C	uc004bqy.1	-	5	463	c.375C>G	c.(373-375)CTC>CTG	p.L125L	RPL12_uc004bqx.1_RNA|RPL12_uc004bqz.1_Silent_p.L92L	NM_000976	NP_000967	P30050	RL12_HUMAN	ribosomal protein L12	125					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						TCTTACCAGAGAGTTCTCTGG	0.443													0	0	0	0.01441	0	80	143										C	130210620	G	C	130210620	2	2	4	1	0	0	0	0	0	0	0	1	13558	929	33	1		1	RPL12	9	130210620	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	4772400	130210620	11002811	115	536										
STXBP1	6812	broad.mit.edu	37	chr9	130422312	130422312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttcccccccatccacagtccGtccactctctcatcagtgac	4	20	3	1	rs34830702	byFrequency	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:130422312G>A	uc004brl.2	+	5	447	c.250G>A	c.(250-252)GTC>ATC	p.V84I	STXBP1_uc004brk.2_Missense_Mutation_p.V84I	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	84			V -> D (in EIEE4; may alter protein structure).		axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						TCCACAGTCCGTCCACTCTCT	0.507													0	0	0	0.01892	0	20	51										A	130422312	G	A	130422312	3	1	4	1	0	0	0	0	1	0	0	0	15351	1145	40	2	268	2	STXBP1	9	130422312	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	211692	130422312	10791119	116	537										
SPTAN1	6709	broad.mit.edu	37	chr9	131388155	131388155	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cacgttcagtccaaggccatCgaggcccggcacgcctccct	10	18	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:131388155C>T	uc004bvl.3	+	47	6275	c.6162C>T	c.(6160-6162)ATC>ATT	p.I2054I	SPTAN1_uc004bvm.3_Silent_p.I2059I|SPTAN1_uc004bvn.3_Silent_p.I2034I|SPTAN1_uc010mye.1_5'Flank|SPTAN1_uc010myf.1_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2054	Spectrin 21.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCAAGGCCATCGAGGCCCGGC	0.602													0	0	0	0.01441	0	73	132										T	131388155	C	T	131388155	2	4	4	1	0	0	0	0	0	0	0	1	15116	874	31	1		1	SPTAN1	9	131388155	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	965843	131388155	9825276	117	538										
COL5A1	1289	broad.mit.edu	37	chr9	137709646	137709646	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcccccaggccccgcaggccCcgaaggcagacagggagaga	14	16	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:137709646C>A	uc004cfe.2	+	54	4581	c.4199C>A	c.(4198-4200)CCC>CAC	p.P1400H		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1400	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCGCAGGCCCCGAAGGCAGA	0.662													1	0	2.80697e-09	0.010729	2.95252e-09	9	5										A	137709646	C	A	137709646	3	1	4	1	0	0	0	0	1	0	0	0	3696	623	22	4	4413	4	COL5A1	9	137709646	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6321491	137709646	3503785	118	539										
COL5A1	1289	broad.mit.edu	37	chr9	137717708	137717708	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtttactgcaacttcacagcCggggggtcgacatgcgtctt	12	11	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:137717708C>T	uc004cfe.2	+	63	5407	c.5025C>T	c.(5023-5025)GCC>GCT	p.A1675A	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1675	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACTTCACAGCCGGGGGGTCGA	0.592													0	0	0	0.015359	0	29	61										T	137717708	C	T	137717708	2	4	4	1	0	0	0	0	0	0	0	1	3696	639	23	2		2	COL5A1	9	137717708	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	8062	137717708	3495723	119	540										
COL5A1	1289	broad.mit.edu	37	chr9	137734025	137734025	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	caagaaaggctaccagaagaCggttctggagatcgacaccc	11	11	1	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:137734025C>T	uc004cfe.2	+	66	5775	c.5393C>T	c.(5392-5394)ACG>ATG	p.T1798M	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1798	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TACCAGAAGACGGTTCTGGAG	0.522													0	0	0	0.013537	0	10	59										T	137734025	C	T	137734025	3	4	4	1	0	0	0	0	1	0	0	0	3696	536	19	2	5655	2	COL5A1	9	137734025	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	16317	137734025	3479406	120	541										
EGFL7	51162	broad.mit.edu	37	chr9	139565433	139565433	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcaatgaaggaagaagtgcaGaggctgcagtccagggtgga	17	6	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:139565433G>A	uc004cid.2	+	8	1514	c.603G>A	c.(601-603)CAG>CAA	p.Q201Q	EGFL7_uc004cif.2_Silent_p.Q201Q|EGFL7_uc004cig.2_RNA|EGFL7_uc010nbp.2_Silent_p.Q201Q|EGFL7_uc004cie.2_Silent_p.Q201Q|EGFL7_uc004cih.2_Silent_p.Q201Q	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	201	Potential.				angiogenesis|vasculogenesis		calcium ion binding			ovary(1)	1	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		AAGAAGTGCAGAGGCTGCAGT	0.697													0	0	0	0.014758	0	4	5										A	139565433	G	A	139565433	2	1	4	1	0	0	0	0	0	0	0	1	4964	933	33	1		1	EGFL7	9	139565433	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1831408	139565433	1647998	121	542										
C10orf140	387640	broad.mit.edu	37	chr10	21804750	21804750	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgtgtcagtgcagggattctCggctttagttgctgctgctc	13	9	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr10:21804750C>A	uc009xkd.2	-	4	4255	c.2002G>T	c.(2002-2004)GAG>TAG	p.E668*	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	587						nucleus	nucleotide binding			ovary(1)	1						CAGGGATTCTCGGCTTTAGTT	0.433													1	0	9.16793e-09	0.00499	9.53733e-09	14	18										A	21804750	C	A	21804750	4	1	4	1	0	0	0	0	0	1	0	0	1595	893	31	3	728	3	C10orf140	10	21804750	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		21804750	113729997	122	543										
BLOC1S2	282991	broad.mit.edu	37	chr10	102045870	102045870	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcacccgtcagttccccagtCaggtaagtggccattttgga	10	12	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr10:102045870C>T	uc001kqw.1	-	2	179	c.156G>A	c.(154-156)CTG>CTA	p.L52L	BLOC1S2_uc001kqv.1_Silent_p.L9L	NM_173809	NP_776170	Q6QNY1	BL1S2_HUMAN	biogenesis of lysosome-related organelles	52					melanosome organization|microtubule nucleation|platelet dense granule organization|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of apoptosis	BLOC-1 complex|centrosome|gamma-tubulin complex|nucleus	gamma-tubulin binding|identical protein binding|protein C-terminus binding			ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.44e-10)|all cancers(201;1.97e-08)		GTTCCCCAGTCAGGTAAGTGG	0.597													0	0	0	0.01441	0	70	167										T	102045870	C	T	102045870	2	4	4	1	0	0	0	0	0	0	0	1	1449	813	29	1		1	BLOC1S2	10	102045870	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	80241120	102045870	33488877	123	544										
INPP5A	3632	broad.mit.edu	37	chr10	134591246	134591246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtgcccagcctggtgtgaccGcatcctcatgtccccgtctg	11	16	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr10:134591246G>A	uc001llp.2	+	13	1297	c.1049G>A	c.(1048-1050)CGC>CAC	p.R350H	INPP5A_uc001llo.1_Missense_Mutation_p.R350H|INPP5A_uc001llq.2_Missense_Mutation_p.R245H	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	350					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TGGTGTGACCGCATCCTCATG	0.652													0	0	0	0.007835	0	36	56										A	134591246	G	A	134591246	3	1	4	1	0	0	0	0	1	0	0	0	7754	1087	38	2	1099	2	INPP5A	10	134591246	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	32545376	134591246	943501	124	545										
CDHR5	53841	broad.mit.edu	37	chr11	621088	621088	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cctccccattaccagtatgtGccccgtggggacagccccgt	10	17	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:621088G>A	uc001lqj.2	-	7	886	c.781C>T	c.(781-783)CAC>TAC	p.H261Y	CDHR5_uc001lqk.2_Missense_Mutation_p.H261Y|CDHR5_uc009ycc.2_Missense_Mutation_p.H95Y|CDHR5_uc009ycd.2_Missense_Mutation_p.H261Y|CDHR5_uc001lql.2_Missense_Mutation_p.H261Y|CDHR5_uc001lqm.2_Missense_Mutation_p.H95Y|CDHR5_uc009yce.1_Missense_Mutation_p.H230Y	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	261	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ACCAGTATGTGCCCCGTGGGG	0.672													0	0	0	0.013726	0	28	49										A	621088	G	A	621088	3	1	4	1	0	0	0	0	1	0	0	0	3122	1319	46	2	1792	2	CDHR5	11	621088	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		621088	134385428	125	546										
LRDD	55367	broad.mit.edu	37	chr11	801284	801284	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gaagctggggggaccgctctGtgacaggcacagcagggggc	19	10	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:801284G>T	uc001lro.1	-	9	1706	c.1564C>A	c.(1564-1566)CAG>AAG	p.Q522K	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.Q522K|LRDD_uc001lrl.1_Missense_Mutation_p.Q376K|LRDD_uc001lrm.1_Missense_Mutation_p.Q209K|LRDD_uc001lrn.1_Missense_Mutation_p.Q376K|LRDD_uc001lrp.1_Missense_Mutation_p.Q160K	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	522	ZU5 2.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGACCGCTCTGTGACAGGCAC	0.677													1	0	7.63505e-26	0.012213	8.47013e-26	27	51										T	801284	G	T	801284	3	4	4	1	0	0	0	0	1	0	0	0	8936	1386	48	4	1200	4	LRDD	11	801284	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	180196	801284	134205232	126	547										
NUP98	4928	broad.mit.edu	37	chr11	3720533	3720533	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	caagctccttcaggtggcccCatagggcttcacatagtgtc	10	13	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:3720533C>A	uc001lyh.2	-	25	4079	c.3788G>T	c.(3787-3789)TGG>TTG	p.W1263L	NUP98_uc001lyi.2_Missense_Mutation_p.W1263L|NUP98_uc001lyg.2_Missense_Mutation_p.W228L	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1280					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CAGGTGGCCccatagggcttc	0.299			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								1	0	5.73435e-26	0.01441	6.38649e-26	40	40										A	3720533	C	A	3720533	3	1	4	1	0	0	0	0	1	0	0	0	10773	595	21	4	1650	4	NUP98	11	3720533	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2919249	3720533	131285983	127	548										
ZNF214	7761	broad.mit.edu	37	chr11	7022651	7022651	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggtctttggaatctgtccctTgaacagtttccccatagttc	8	11	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:7022651T>G	uc001mfa.2	-	3	566	c.263A>C	c.(262-264)CAA>CCA	p.Q88P	ZNF214_uc010ray.1_Missense_Mutation_p.Q88P|ZNF214_uc009yfh.1_Missense_Mutation_p.Q88P	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		ATCTGTCCCTTGAACAGTTTC	0.438													0	0	0	0.01441	0	122	166										G	7022651	T	G	7022651	3	3	4	1	0	0	0	0	1	0	0	0	17767	1812	63	5	1561	5	ZNF214	11	7022651	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	3302118	7022651	127983865	128	549										
MICAL2	9645	broad.mit.edu	37	chr11	12247845	12247845	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tggcatctgcccaggagcctGacaagctcagcatggtcatg	12	12	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:12247845G>A	uc001mjz.2	+	14	2104	c.1816G>A	c.(1816-1818)GAC>AAC	p.D606N	MICAL2_uc010rch.1_Missense_Mutation_p.D606N|MICAL2_uc001mka.2_Missense_Mutation_p.D606N|MICAL2_uc010rci.1_Missense_Mutation_p.D606N|MICAL2_uc001mkb.2_Missense_Mutation_p.D606N|MICAL2_uc001mkc.2_Missense_Mutation_p.D606N|MICAL2_uc001mkd.2_Missense_Mutation_p.D435N|MICAL2_uc010rcj.1_Missense_Mutation_p.D8N	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	606	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CCAGGAGCCTGACAAGCTCAG	0.572													0	0	0	0.010818	0	30	57										A	12247845	G	A	12247845	3	1	4	1	0	0	0	0	1	0	0	0	9570	1290	45	1	1862	1	MICAL2	11	12247845	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	5225194	12247845	122758671	129	550										
KCNJ11	3767	broad.mit.edu	37	chr11	17409117	17409117	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agggtctcagccctgcggtgGgcttgggcagtcttcatgaa	15	10	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:17409117G>T	uc001mna.2	-	1	1090	c.522C>A	c.(520-522)GCC>GCA	p.A174A	KCNJ11_uc001mnb.3_Silent_p.A87A	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	174						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		CCCTGCGGTGGGCTTGGGCAG	0.597											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.62473e-10	0.012319	3.82685e-10	17	21										T	17409117	G	T	17409117	2	4	4	1	0	0	0	0	0	0	0	1	8045	1219	43	4		4	KCNJ11	11	17409117	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	5161272	17409117	117597399	130	551										
ANO3	63982	broad.mit.edu	37	chr11	26655840	26655840	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atttaaacagttccatcttcTatatcgctttctttttggga	5	8	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:26655840T>C	uc001mqt.3	+	19	2108	c.1963T>C	c.(1963-1965)TAT>CAT	p.Y655H	ANO3_uc010rdr.1_Missense_Mutation_p.Y639H|ANO3_uc010rds.1_Missense_Mutation_p.Y494H|ANO3_uc010rdt.1_Missense_Mutation_p.Y509H	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	655	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTCCATCTTCTATATCGCTTT	0.368													0	0	0	0.008291	0	10	11										C	26655840	T	C	26655840	3	2	4	1	0	0	0	0	1	0	0	0	698	1522	53	5	2037	5	ANO3	11	26655840	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	9246723	26655840	108350676	131	552										
RAG1	5896	broad.mit.edu	37	chr11	36595001	36595001	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gaagaagctcaaaaggaaaaGaaggattcctttgaggggaa	13	4	1	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:36595001G>A	uc001mwu.3	+	2	271	c.147G>A	c.(145-147)AAG>AAA	p.K49K	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	49	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				AAAAGGAAAAGAAGGATTCCT	0.438									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.008291	0	11	23										A	36595001	G	A	36595001	2	1	4	1	0	0	0	0	0	0	0	1	13003	933	33	1		1	RAG1	11	36595001	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	9939161	36595001	98411515	132	553										
OR4C46	119749	broad.mit.edu	37	chr11	51515382	51515382	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgtgttttttgtcatctataTcatcactgtggtgggatatg	10	5	4	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:51515382T>G	uc010ric.1	+	1	101	c.101T>G	c.(100-102)ATC>AGC	p.I34S		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTCATCTATATCATCACTGTG	0.433													0	0	0	0.01441	0	51	86										G	51515382	T	G	51515382	3	3	4	1	0	0	0	0	1	0	0	0	11051	1435	50	5	103	5	OR4C46	11	51515382	Missense_Mutation	SNP	T	TCGA-BL-A3JM-01A-12D-A21A-08	14920381	51515382	83491134	133	554										
OR5D18	219438	broad.mit.edu	37	chr11	55587569	55587569	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atcctatgcctggggagtctCatgttccttggaactgacgt	11	10	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:55587569C>A	uc010rin.1	+	1	464	c.464C>A	c.(463-465)TCA>TAA	p.S155*		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TGGGGAGTCTCATGTTCCTTG	0.478													1	0	3.50607e-19	0.01441	3.80047e-19	42	70										A	55587569	C	A	55587569	4	1	4	1	0	0	0	0	0	1	0	0	11157	838	29	3	466	3	OR5D18	11	55587569	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	4072187	55587569	79418947	134	555										
FAM111B	374393	broad.mit.edu	37	chr11	58893255	58893255	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgcgtttcctccaggactatGgcgacagatttctcctcaac	8	13	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:58893255G>A	uc001nnl.2	+	4	1928	c.1685G>A	c.(1684-1686)TGG>TAG	p.W562*	FAM111B_uc001nnm.2_Nonsense_Mutation_p.W532*|FAM111B_uc010rko.1_Nonsense_Mutation_p.W532*	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	562							catalytic activity	p.W562*(1)		ovary(2)	2						CCAGGACTATGGCGACAGATT	0.373													0	0	0	0.020292	0	14	37										A	58893255	G	A	58893255	4	1	4	1	0	0	0	0	0	1	0	0	5400	1357	47	2	1691	2	FAM111B	11	58893255	Nonsense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	3305686	58893255	76113261	135	556										
CD6	923	broad.mit.edu	37	chr11	60777201	60777201	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggctgtggaactgcggttgaGaggcccaaggggctgcccca	17	11	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:60777201G>A	uc001nqq.2	+	5	1162	c.939G>A	c.(937-939)GAG>GAA	p.E313E	CD6_uc009yni.2_Intron|CD6_uc009ynj.2_Intron|CD6_uc001nqp.2_Silent_p.E313E|CD6_uc001nqr.2_Silent_p.E313E|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.E313E	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	313	SRCR 3.|Extracellular (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						CTGCGGTTGAGAGGCCCAAGG	0.592													0	0	0	0.013726	0	29	54										A	60777201	G	A	60777201	2	1	4	1	0	0	0	0	0	0	0	1	3028	933	33	1		1	CD6	11	60777201	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1883946	60777201	74229315	136	557										
DPP3	10072	broad.mit.edu	37	chr11	66262701	66262701	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aaaaaggagcattcaactttGaccaggaaacagtgatcaac	8	8	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:66262701G>A	uc001oig.1	+	13	1476	c.1414G>A	c.(1414-1416)GAC>AAC	p.D472N	DPP3_uc001oif.1_Missense_Mutation_p.D472N|DPP3_uc010rpe.1_Missense_Mutation_p.D461N|DPP3_uc001oih.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	472					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						ATTCAACTTTGACCAGGAAAC	0.627													0	0	0	0.01441	0	52	80										A	66262701	G	A	66262701	3	1	4	1	0	0	0	0	1	0	0	0	4728	1290	45	1	1460	1	DPP3	11	66262701	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	5485500	66262701	68743815	137	558										
BBS1	582	broad.mit.edu	37	chr11	66288833	66288833	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gcctgccgcaatggaaacatCtatattctgagaaggtagcc	10	10	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:66288833C>G	uc001oij.1	+	9	828	c.816C>G	c.(814-816)ATC>ATG	p.I272M	BBS1_uc001oii.1_Missense_Mutation_p.I309M|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Missense_Mutation_p.I175M|BBS1_uc001oik.1_Missense_Mutation_p.I196M|BBS1_uc001oil.1_Intron|ZDHHC24_uc001oim.1_RNA|ZDHHC24_uc009yrg.1_3'UTR|BBS1_uc010rph.1_5'Flank	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	272					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						ATGGAAACATCTATATTCTGA	0.552									Bardet-Biedl_syndrome				0	0	0	0.007413	0	16	25										G	66288833	C	G	66288833	3	3	4	1	0	0	0	0	1	0	0	0	1335	903	32	1	850	1	BBS1	11	66288833	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	26132	66288833	68717683	138	559										
PITPNM1	9600	broad.mit.edu	37	chr11	67262389	67262389	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gggctgtagatggacggctcCtcgcattccgccagctgtgg	15	12	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:67262389C>A	uc001olx.2	-	17	2859	c.2670G>T	c.(2668-2670)GAG>GAT	p.E890D	PITPNM1_uc001olw.2_Missense_Mutation_p.E172D|PITPNM1_uc001oly.2_Missense_Mutation_p.E890D|PITPNM1_uc001olz.2_Missense_Mutation_p.E889D	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	890					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGGACGGCTCCTCGCATTCCG	0.692													1	0	1.21526e-53	0.01441	1.37504e-53	84	130										A	67262389	C	A	67262389	3	1	4	1	0	0	0	0	1	0	0	0	11950	680	24	4	1092	4	PITPNM1	11	67262389	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	973556	67262389	67744127	139	560										
LRP5	4041	broad.mit.edu	37	chr11	68174203	68174203	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aacgacgtggccatcccgctCacgggcgtcaaggaggcctc	13	15	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:68174203C>T	uc001ont.2	+	9	2088	c.2013C>T	c.(2011-2013)CTC>CTT	p.L671L	LRP5_uc009ysg.2_Silent_p.L81L	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	671	Beta-propeller 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CCATCCCGCTCACGGGCGTCA	0.587													0	0	0	0.008291	0	10	29										T	68174203	C	T	68174203	2	4	4	1	0	0	0	0	0	0	0	1	8960	813	29	1		1	LRP5	11	68174203	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	911814	68174203	66832313	140	561										
ANO1	55107	broad.mit.edu	37	chr11	70028637	70028637	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atctccttcacgtctgacttCatcccgcgcctggtgtacct	7	16	4	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:70028637C>T	uc001opj.2	+	24	2738	c.2433C>T	c.(2431-2433)TTC>TTT	p.F811F	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Silent_p.F520F|ANO1_uc010rql.1_5'UTR	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	811	Helical; (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CGTCTGACTTCATCCCGCGCC	0.612													0	0	0	0.00632	0	22	42										T	70028637	C	T	70028637	2	4	4	1	0	0	0	0	0	0	0	1	695	825	29	1		1	ANO1	11	70028637	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1854434	70028637	64977879	141	562										
RSF1	51773	broad.mit.edu	37	chr11	77411897	77411897	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttttttatcagctttctgatCtctgatctcagccacttttg	5	10	4	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:77411897C>T	uc001oyn.2	-	6	2497	c.2377G>A	c.(2377-2379)GAT>AAT	p.D793N	RSF1_uc001oym.2_Missense_Mutation_p.D541N	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	793					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			GCTTTCTGATCTCTGATCTCA	0.383													0	0	0	0.008871	0	18	27										T	77411897	C	T	77411897	3	4	4	1	0	0	0	0	1	0	0	0	13699	913	32	1	1992	1	RSF1	11	77411897	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	7383260	77411897	57594619	142	563										
JRKL	8690	broad.mit.edu	37	chr11	96124087	96124087	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aatggttcaaccagcaaagaGcaaaagggaatcccatatct	8	9	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:96124087G>C	uc009ywu.2	+	2	526	c.274G>C	c.(274-276)GCA>CCA	p.A92P	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Missense_Mutation_p.A92P	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	92	HTH CENPB-type.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		CCAGCAAAGAGCAAAAGGGAA	0.443													0	0	0	0.01441	0	46	17										C	96124087	G	C	96124087	3	2	4	1	0	0	0	0	1	0	0	0	7965	971	34	4	276	4	JRKL	11	96124087	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	18712190	96124087	38882429	143	564										
IL10RA	3587	broad.mit.edu	37	chr11	117866303	117866303	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cacatctctctgggcctgcaGatttcaccgtgaccaacgtc	8	15	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:117866303G>T	uc001prv.2	+	6	766	c.689_splice	c.e6-1	p.Y230_splice	IL10RA_uc010rxl.1_Splice_Site_p.Y210_splice|IL10RA_uc010rxm.1_Splice_Site_p.Y210_splice|IL10RA_uc010rxn.1_Splice_Site_p.Y81_splice|IL10RA_uc001prw.2_Splice_Site_p.Y81_splice	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor							integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TGGGCCTGCAGATTTCACCGT	0.577													1	0	9.50027e-55	0.01441	1.07923e-54	94	24										T	117866303	G	T	117866303	5	4	4	1	0	0	0	0	0	0	1	0	7620	956	33	3	710	3	IL10RA	11	117866303	Splice_Site	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	21742216	117866303	17140213	144	565										
MLL	4297	broad.mit.edu	37	chr11	118355688	118355688	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtgccagtagtgggcatgtaGaggtaaggcatcctgcttct	14	8	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:118355688G>C	uc001pta.2	+	10	4353	c.4330G>C	c.(4330-4332)GAG>CAG	p.E1444Q	MLL_uc001ptb.2_Missense_Mutation_p.E1444Q|MLL_uc001pte.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1444	PHD-type 1.	Breakpoint for translocation to form MLL- LPP.|Breakpoint for translocation to form MLL- GAS7 oncogene.			apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGGGCATGTAGAGGTAAGGCA	0.423			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.010729	0	12	21										C	118355688	G	C	118355688	3	2	4	1	0	0	0	0	1	0	0	0	9620	943	33	1	4368	1	MLL	11	118355688	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	489385	118355688	16650828	145	566										
OR8A1	390275	broad.mit.edu	37	chr11	124440079	124440079	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agggtttaacgaagagagcaGacctccagctccccctcttt	9	13	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:124440079G>A	uc010san.1	+	1	115	c.115G>A	c.(115-117)GAC>AAC	p.D39N		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	39	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GAAGAGAGCAGACCTCCAGCT	0.527													0	0	0	0.006122	0	15	28										A	124440079	G	A	124440079	3	1	4	1	0	0	0	0	1	0	0	0	11225	942	33	1	117	1	OR8A1	11	124440079	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	6084391	124440079	10566437	146	567										
ARHGAP32	9743	broad.mit.edu	37	chr11	128844063	128844063	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagccttactctgactgcttGagacagactgatcctctttc	7	13	2	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:128844063G>C	uc009zcp.2	-	20	2987	c.2987C>G	c.(2986-2988)TCA>TGA	p.S996*	ARHGAP32_uc009zcq.1_Nonsense_Mutation_p.S956*|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Nonsense_Mutation_p.S647*	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	996					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CTGACTGCTTGAGACAGACTG	0.473													0	0	0	0.010504	0	21	43										C	128844063	G	C	128844063	4	2	4	1	0	0	0	0	0	1	0	0	881	1294	45	1	3288	1	ARHGAP32	11	128844063	Nonsense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	4403984	128844063	6162453	147	568										
SPATA19	219938	broad.mit.edu	37	chr11	133715054	133715054	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcaaccaatgatgtagtacaGacacagcctcactttccaca	5	13	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:133715054G>C	uc001qgv.1	-	2	161	c.110C>G	c.(109-111)TCT>TGT	p.S37C		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	37					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		ATGTAGTACAGACACAGCCTC	0.458													0	0	0	0.011902	0	34	60										C	133715054	G	C	133715054	3	2	4	1	0	0	0	0	1	0	0	0	15003	942	33	1	413	1	SPATA19	11	133715054	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	4870991	133715054	1291462	148	569										
PLEKHG6	55200	broad.mit.edu	37	chr12	6436757	6436759	+	In_Frame_Del	DEL	GAA	GAA	-													0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	acccaccaacctggtctgagGaagaagatggggcctccgag							TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:6436757_6436759delGAA	uc001qnr.2	+	15	2156_2158	c.2008_2010delGAA	c.(2008-2010)GAAdel	p.E671del	PLEKHG6_uc010sew.1_In_Frame_Del_p.E671del|PLEKHG6_uc010sex.1_In_Frame_Del_p.E639del	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	671					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						CTGGTCTGAGGAAGAAGATGGGG	0.631																		5	6	---	---								-	6436759	GAA	-	6436757	7	5	4	1	0	1	0	1	0	0	0	0	12074	1175	41	0	2108	0	PLEKHG6	12	6436757	In_Frame_Del	DEL	GAA	TCGA-BL-A3JM-01A-12D-A21A-08		6436757	127415138	149	570										
A2M	2	broad.mit.edu	37	chr12	9248286	9248286	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgaggtccttttctggtagcAggttgtaaacctgtacaaat	10	7	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:9248286A>G	uc001qvk.1	-	16	1975	c.1862T>C	c.(1861-1863)CTG>CCG	p.L621P	A2M_uc009zgk.1_Missense_Mutation_p.L471P	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	621					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TTCTGGTAGCAGGTTGTAAAC	0.308													0	0	0	0.007413	0	12	58										G	9248286	A	G	9248286	3	3	4	1	0	0	0	0	1	0	0	0	4	188	7	5	2646	5	A2M	12	9248286	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	2811529	9248286	124603609	150	571										
CDKN1B	1027	broad.mit.edu	37	chr12	12871015	12871016	+	Frame_Shift_Ins	INS	-	-	TTCT													0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gagtggcaagaggtggagaaINSgggcagcttgcccgagttct							TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:12871015_12871016insTTCT	uc001rat.2	+	1	714_715	c.242_243insTTCT	c.(241-243)AAGfs	p.K81fs		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	81					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		GAGGTGGAGAAGGGCAGCTTGC	0.614									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4									72	103	---	---								TTCT	12871016	-	TTCT	12871015	7	5	4	1	0	1	1	0	0	0	0	0	3159	72	3	0	244	0	CDKN1B	12	12871015	Frame_Shift_Ins	INS	-	TCGA-BL-A3JM-01A-12D-A21A-08	3622729	12871015	120980880	151	572										
PTPRO	5800	broad.mit.edu	37	chr12	15677896	15677896	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggaaaaaagaaaattaaaaaGagtgtatgtttctttgaatg	9	1	1	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:15677896G>C	uc001rcv.1	+	11	2214	c.2040G>C	c.(2038-2040)AAG>AAC	p.K680N	PTPRO_uc001rcw.1_Missense_Mutation_p.K680N	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	680	Fibronectin type-III 7.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				AAATTAAAAAGAGTGTATGTT	0.289													0	0	0	0.010729	0	10	31										C	15677896	G	C	15677896	3	2	4	1	0	0	0	0	1	0	0	0	12809	933	33	1	2082	1	PTPRO	12	15677896	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2806881	15677896	118173999	152	573										
PDE3A	5139	broad.mit.edu	37	chr12	20766459	20766459	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cgacctcctggcagacccttCtcttccaccaaacgtgtgca	7	17	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:20766459C>G	uc001reh.1	+	3	1116	c.1094C>G	c.(1093-1095)TCT>TGT	p.S365C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	365				HGLITDLLADPSLPPNVC -> TASLPTSWQTLLFHQTCA (in Ref. 3 and 4).	lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GCAGACCCTTCTCTTCCACCA	0.557													0	0	0	0.01441	0	60	45										G	20766459	C	G	20766459	3	3	4	1	0	0	0	0	1	0	0	0	11637	913	32	1	1104	1	PDE3A	12	20766459	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	5088563	20766459	113085436	153	574										
ABCC9	10060	broad.mit.edu	37	chr12	22059097	22059097	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agtgcaaaggttttgagactAgatagttctttcattcttgt	9	5	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:22059097A>G	uc001rfi.1	-	10	1601	c.1581T>C	c.(1579-1581)TCT>TCC	p.S527S	ABCC9_uc001rfh.2_Silent_p.S527S|ABCC9_uc001rfj.1_Silent_p.S527S	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	527	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTTGAGACTAGATAGTTCTT	0.368													0	0	0	0.027356	0	18	45										G	22059097	A	G	22059097	2	3	4	1	0	0	0	0	0	0	0	1	59	407	15	5		5	ABCC9	12	22059097	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	1292638	22059097	111792798	154	575										
NCKAP5L	57701	broad.mit.edu	37	chr12	50189001	50189001	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcaccttctcctcgatggctGagtgtggggccagcccctca	11	15	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:50189001G>C	uc009zlk.2	-	8	2844	c.2642C>G	c.(2641-2643)TCA>TGA	p.S881*	NCKAP5L_uc001rvc.3_Nonsense_Mutation_p.S85*|NCKAP5L_uc001rvb.2_Nonsense_Mutation_p.S474*	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	877										central_nervous_system(1)	1						CTCGATGGCTGAGTGTGGGGC	0.662													0	0	0	0.01441	0	94	72										C	50189001	G	C	50189001	4	2	4	1	0	0	0	0	0	1	0	0	10224	1294	45	1	1386	1	NCKAP5L	12	50189001	Nonsense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	28129904	50189001	83662894	155	576										
BIN2	51411	broad.mit.edu	37	chr12	51707619	51707619	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagattacctgttgttggtaGaagttgctagcgctttgttc	11	7	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:51707619G>A	uc001ryg.2	-	2	202	c.150C>T	c.(148-150)TTC>TTT	p.F50F	BIN2_uc009zlz.2_Silent_p.F50F|BIN2_uc001ryh.2_5'UTR|BIN2_uc010sng.1_Silent_p.F24F	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	50	BAR.					cytoplasm	protein binding			ovary(1)	1						GTTGTTGGTAGAAGTTGCTAG	0.468													0	0	0	0.027894	0	34	43										A	51707619	G	A	51707619	2	1	4	1	0	0	0	0	0	0	0	1	1433	933	33	1		1	BIN2	12	51707619	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1518618	51707619	82144276	156	577										
KRT79	338785	broad.mit.edu	37	chr12	53215788	53215788	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cccttggtggcccccccactCccacccagggagatgccacc	9	21	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:53215788C>G	uc001sbb.2	-	9	1509	c.1476G>C	c.(1474-1476)GGG>GGC	p.G492G	KRT79_uc001sba.2_Silent_p.G263G	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	492	Tail.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CCCCCCCACTCCCACCCAGGG	0.612													0	0	0	0.009718	0	39	55										G	53215788	C	G	53215788	2	3	4	1	0	0	0	0	0	0	0	1	8492	842	30	1		1	KRT79	12	53215788	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1508169	53215788	80636107	157	578										
GLI1	2735	broad.mit.edu	37	chr12	57861869	57861869	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagacagtgcatggtcctgaCgcccatgtgaccaaacggca	11	12	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:57861869C>T	uc001snx.2	+	10	1248	c.1170C>T	c.(1168-1170)GAC>GAT	p.D390D	GLI1_uc009zpq.2_Silent_p.D262D	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	390					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			ATGGTCCTGACGCCCATGTGA	0.572													0	0	0	0.027356	0	23	67										T	57861869	C	T	57861869	2	4	4	1	0	0	0	0	0	0	0	1	6437	535	19	2		2	GLI1	12	57861869	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	4646081	57861869	75990026	158	579										
LRRIQ1	84125	broad.mit.edu	37	chr12	85450509	85450509	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aaagaaattgaggagaacccAaaagacaatgcttggaatag	10	5	0	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:85450509A>G	uc001tac.2	+	8	2049	c.1938A>G	c.(1936-1938)CCA>CCG	p.P646P	LRRIQ1_uc001tab.1_Silent_p.P646P|LRRIQ1_uc001taa.1_Silent_p.P621P	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	646										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AGGAGAACCCAAAAGACAATG	0.308													0	0	0	0.021553	0	6	13										G	85450509	A	G	85450509	2	3	4	1	0	0	0	0	0	0	0	1	9029	117	5	5		5	LRRIQ1	12	85450509	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	27588640	85450509	48401386	159	580										
C12orf42	374470	broad.mit.edu	37	chr12	103699968	103699968	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agtaaaaatcaatggggcctCatcagtttcactggatggtg	11	7	4	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:103699968C>T	uc001tjt.2	-	5	503	c.415G>A	c.(415-417)GAG>AAG	p.E139K	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Missense_Mutation_p.E139K|C12orf42_uc001tju.2_Missense_Mutation_p.E44K	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	139										ovary(1)|central_nervous_system(1)	2						AATGGGGCCTCATCAGTTTCA	0.463													0	0	0	0.010504	0	17	14										T	103699968	C	T	103699968	3	4	4	1	0	0	0	0	1	0	0	0	1688	835	29	1	675	1	C12orf42	12	103699968	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	18249459	103699968	30151927	160	581										
TBX5	6910	broad.mit.edu	37	chr12	114832653	114832653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	attattttcatccgctttcaCgatgtgtaatctaggctggt	8	8	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:114832653C>T	uc001tvo.2	-	6	1051	c.556G>A	c.(556-558)GTG>ATG	p.V186M	TBX5_uc001tvp.2_Missense_Mutation_p.V186M|TBX5_uc001tvq.2_Missense_Mutation_p.V136M|TBX5_uc010syv.1_Missense_Mutation_p.V186M	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	186	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCCGCTTTCACGATGTGTAAT	0.363													0	0	0	0.01441	0	109	101										T	114832653	C	T	114832653	3	4	4	1	0	0	0	0	1	0	0	0	15658	536	19	2	1083	2	TBX5	12	114832653	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	11132685	114832653	19019242	161	582										
IL31	386653	broad.mit.edu	37	chr12	122658748	122658748	+	Splice_Site	DEL	G	G	-													0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agagcaaggccagcttcagtGggggcttctggagccagatg							TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:122658748delG	uc001ubv.2	-	1	1	c.-26_splice	c.e1-1		LRRC43_uc001ubw.3_Intron|LRRC43_uc009zxl.1_Intron	NM_001014336	NP_001014358	Q6EBC2	IL31_HUMAN	interleukin 31 precursor							extracellular space	cytokine activity			central_nervous_system(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CAGCTTCAGTGGGGGCTTCTG	0.572																		33	48	---	---								-	122658748	G	-	122658748	8	5	4	1	0	1	0	1	0	0	1	0	7690	1363	47	0		0	IL31	12	122658748	Splice_Site	DEL	G	TCGA-BL-A3JM-01A-12D-A21A-08	7826095	122658748	11193147	162	583										
DNAH10	196385	broad.mit.edu	37	chr12	124345628	124345628	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtcatagaactctacggcatCctggacccaaccacccgaga	8	15	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:124345628C>T	uc001uft.3	+	38	6490	c.6465C>T	c.(6463-6465)ATC>ATT	p.I2155I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2155	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCTACGGCATCCTGGACCCAA	0.488													0	0	0	0.015359	0	31	36										T	124345628	C	T	124345628	2	4	4	1	0	0	0	0	0	0	0	1	4598	845	30	1		1	DNAH10	12	124345628	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1686880	124345628	9506267	163	584										
PIWIL1	9271	broad.mit.edu	37	chr12	130834457	130834457	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctgggaccagaatcccaagaGcacctttaagaaagccgacg	10	12	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:130834457G>A	uc001uik.2	+	9	1079	c.989G>A	c.(988-990)AGC>AAC	p.S330N	PIWIL1_uc001uij.1_Missense_Mutation_p.S330N	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	330	PAZ.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AATCCCAAGAGCACCTTTAAG	0.408													0	0	0	0.00499	0	14	46										A	130834457	G	A	130834457	3	1	4	1	0	0	0	0	1	0	0	0	11957	971	34	2	1019	2	PIWIL1	12	130834457	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	6488829	130834457	3017438	164	585										
FLT3	2322	broad.mit.edu	37	chr13	28597565	28597565	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcttcaaatgtaagcacattCaagtcctcctcttcttccag	4	13	5	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:28597565C>G	uc001urw.2	-	19	2422	c.2340G>C	c.(2338-2340)TTG>TTC	p.L780F	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.L780F	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	780	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TAAGCACATTCAAGTCCTCCT	0.353			Mis|O		AML|ALL								0	0	0	0.00308	0	7	25										G	28597565	C	G	28597565	3	3	4	1	0	0	0	0	1	0	0	0	5942	825	29	1	665	1	FLT3	13	28597565	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		28597565	86572313	165	586										
FRY	10129	broad.mit.edu	37	chr13	32783164	32783164	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggaaggtgacgtgactgcttCtcacgggctgagaggaaatg	16	7	1	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:32783164C>G	uc001utx.2	+	32	4689	c.4193C>G	c.(4192-4194)TCT>TGT	p.S1398C	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GTGACTGCTTCTCACGGGCTG	0.592													0	0	0	0.027894	0	38	91										G	32783164	C	G	32783164	3	3	4	1	0	0	0	0	1	0	0	0	6063	913	32	1	4319	1	FRY	13	32783164	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	4185599	32783164	82386714	166	587										
ALG5	29880	broad.mit.edu	37	chr13	37563687	37563687	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	acacgtactttgtcacttccAtatttctggcaatatttaaa	4	9	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:37563687A>G	uc001uvy.2	-	5	448	c.381T>C	c.(379-381)TAT>TAC	p.Y127Y	ALG5_uc010teq.1_Silent_p.Y97Y|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	127	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		TGTCACTTCCATATTTCTGGC	0.284													0	0	0	0.016522	0	19	34										G	37563687	A	G	37563687	2	3	4	1	0	0	0	0	0	0	0	1	521	224	8	5		5	ALG5	13	37563687	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	4780523	37563687	77606191	167	588										
TSC22D1	8848	broad.mit.edu	37	chr13	45147390	45147390	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgctaggctgctgctactccCatctgaaactgctgacattc	8	13	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:45147390C>T	uc001uzn.3	-	1	3312	c.2821G>A	c.(2821-2823)GGG>AGG	p.G941R	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	941					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CTGCTACTCCCATCTGAAACT	0.547													0	0	0	0.010818	0	30	16										T	45147390	C	T	45147390	3	4	4	1	0	0	0	0	1	0	0	0	16604	594	21	2	541	2	TSC22D1	13	45147390	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	7583703	45147390	70022488	168	589										
DACH1	1602	broad.mit.edu	37	chr13	72440381	72440381	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tttccactggggacggggttGagtacacgggtttcccgggg	17	9	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:72440381G>C	uc010thn.1	-	2	944	c.521C>G	c.(520-522)TCA>TGA	p.S174*	DACH1_uc010tho.1_Nonsense_Mutation_p.S174*|DACH1_uc010thp.1_Nonsense_Mutation_p.S174*	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	174					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GGACGGGGTTGAGTACACGGG	0.398													0	0	0	0.021553	0	6	14										C	72440381	G	C	72440381	4	2	4	1	0	0	0	0	0	1	0	0	4220	1294	45	1	1643	1	DACH1	13	72440381	Nonsense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	27292991	72440381	42729497	169	590										
KLF5	688	broad.mit.edu	37	chr13	73636090	73636090	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtatagacgagacagtgcctCagtcgtagaccagttcttca	10	10	3	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:73636090C>T	uc001vje.2	+	2	677	c.353C>T	c.(352-354)TCA>TTA	p.S118L	KLF5_uc001vjd.2_Missense_Mutation_p.S27L	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	118					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GACAGTGCCTCAGTCGTAGAC	0.443													0	0	0	0.027894	0	33	110										T	73636090	C	T	73636090	3	4	4	1	0	0	0	0	1	0	0	0	8349	838	29	1	359	1	KLF5	13	73636090	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1195709	73636090	41533788	170	591										
RBM26	64062	broad.mit.edu	37	chr13	79942951	79942951	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cttcatgaaattcagaccaaCtttcggtagtgttgtttcca	7	9	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:79942951C>A	uc001vkz.2	-	6	823	c.809G>T	c.(808-810)AGT>ATT	p.S270I	RBM26_uc001vky.2_Missense_Mutation_p.S270I|RBM26_uc001vla.2_Missense_Mutation_p.S270I|RBM26_uc001vkx.2_5'UTR|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	270					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTCAGACCAACTTTCGGTAGT	0.433													1	0	9.14704e-12	0.00874	9.72944e-12	37	67										A	79942951	C	A	79942951	3	1	4	1	0	0	0	0	1	0	0	0	13126	565	20	4	2197	4	RBM26	13	79942951	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	6306861	79942951	35226927	171	592										
KDELC1	79070	broad.mit.edu	37	chr13	103445990	103445990	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tagtgacataggctctgcctCtgtccaaatctttttgggat	9	9	3	1	rs144061173		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:103445990C>T	uc001vpq.3	-	3	939	c.555G>A	c.(553-555)CAG>CAA	p.Q185Q	KDELC1_uc001vpr.3_5'UTR	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	185						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGCTCTGCCTCTGTCCAAATC	0.383													0	0	0	0.023175	0	34	84										T	103445990	C	T	103445990	2	4	4	1	0	0	0	0	0	0	0	1	8117	912	32	1		1	KDELC1	13	103445990	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	23503039	103445990	11723888	172	593										
POTEG	404785	broad.mit.edu	37	chr14	19553758	19553758	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgctgcagggggagcggcaaGagcaaagtgggcccttgggg	20	8	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:19553758G>C	uc001vuz.1	+	1	394	c.342G>C	c.(340-342)AAG>AAC	p.K114N	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	114										ovary(1)	1						GGAGCGGCAAGAGCAAAGTGG	0.597													0	0	0	0.01441	0	61	680										C	19553758	G	C	19553758	3	2	4	1	0	0	0	0	1	0	0	0	12266	933	33	1	344	1	POTEG	14	19553758	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		19553758	87795782	173	594										
SYNE2	23224	broad.mit.edu	37	chr14	64690078	64690078	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agcaagtgtcccaagatttaAtggccttgcagggaacccag	11	10	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:64690078A>G	uc001xgm.2	+	112	20523	c.20293A>G	c.(20293-20295)ATG>GTG	p.M6765V	SYNE2_uc001xgl.2_Missense_Mutation_p.M6788V|SYNE2_uc010apy.2_Missense_Mutation_p.M3150V|SYNE2_uc001xgn.2_Missense_Mutation_p.M1727V|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.M735V|SYNE2_uc001xgq.2_Missense_Mutation_p.M1144V|SYNE2_uc001xgr.2_Missense_Mutation_p.M548V|SYNE2_uc010tsi.1_Missense_Mutation_p.M422V|SYNE2_uc001xgs.2_Missense_Mutation_p.M436V|SYNE2_uc001xgt.2_Missense_Mutation_p.M310V	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6765	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAAGATTTAATGGCCTTGCA	0.428													0	0	0	0.00499	0	15	28										G	64690078	A	G	64690078	3	3	4	1	0	0	0	0	1	0	0	0	15443	101	4	5	20850	5	SYNE2	14	64690078	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	45136320	64690078	42659462	174	595										
PAPOLA	10914	broad.mit.edu	37	chr14	97022284	97022284	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	attccagtgaaagctcagggGgtaaggagattgggtttgtc	15	5	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:97022284G>A	uc001yfq.2	+	18	1975	c.1765G>A	c.(1765-1767)GGT>AGT	p.G589S	PAPOLA_uc001yfr.2_Missense_Mutation_p.G588S|PAPOLA_uc010twv.1_Missense_Mutation_p.G589S|PAPOLA_uc010avp.2_Missense_Mutation_p.G339S	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	589	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AAGCTCAGGGGGTAAGGAGAT	0.403													0	0	0	0.015359	0	32	29										A	97022284	G	A	97022284	3	1	4	1	0	0	0	0	1	0	0	0	11429	1246	43	2	1835	2	PAPOLA	14	97022284	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	32332206	97022284	10327256	175	596										
DYNC1H1	1778	broad.mit.edu	37	chr14	102461424	102461424	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atgacggaattccattcccaGatctcaaaggtgaggacata	9	9	1	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:102461424G>A	uc001yks.2	+	14	3599	c.3435G>A	c.(3433-3435)CAG>CAA	p.Q1145Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1145	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCCATTCCCAGATCTCAAAGG	0.463													0	0	0	0.012319	0	21	35										A	102461424	G	A	102461424	2	1	4	1	0	0	0	0	0	0	0	1	4841	933	33	1		1	DYNC1H1	14	102461424	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	5439140	102461424	4888116	176	597										
DYNC1H1	1778	broad.mit.edu	37	chr14	102476256	102476256	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atggccatcttcatcaccatGaaccctggctacgcgggccg	10	15	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:102476256G>C	uc001yks.2	+	30	6218	c.6054G>C	c.(6052-6054)ATG>ATC	p.M2018I		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2018	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCATCACCATGAACCCTGGCT	0.547													0	0	0	0.017118	0	31	50										C	102476256	G	C	102476256	3	2	4	1	0	0	0	0	1	0	0	0	4841	1290	45	1	6172	1	DYNC1H1	14	102476256	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	14832	102476256	4873284	177	598										
RORA	6095	broad.mit.edu	37	chr15	60919554	60919554	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagtctctaagtcactgtctCctggggccccctcattcatg	8	15	5	0	rs139672315	by1000genomes	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr15:60919554C>T	uc002agv.2	-	1	176	c.20G>A	c.(19-21)GGA>GAA	p.G7E	RORA_uc002agw.2_Missense_Mutation_p.G7E|RORA_uc002agx.2_Intron	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	7	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GTCACTGTCTCCTGGGGCCCC	0.547													0	0	0	0.01441	0	44	87										T	60919554	C	T	60919554	3	4	4	1	0	0	0	0	1	0	0	0	13528	855	30	1	1871	1	RORA	15	60919554	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		60919554	41611838	178	599										
SV2B	9899	broad.mit.edu	37	chr15	91769539	91769539	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	attatgggggctatgctcccAgtgatggctattaccgcggc	13	10	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr15:91769539A>G	uc002bqv.2	+	1	437	c.46A>G	c.(46-48)AGT>GGT	p.S16G	SV2B_uc002bqt.2_Missense_Mutation_p.S16G|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	16	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTATGCTCCCAGTGATGGCTA	0.522													0	0	0	0.014323	0	20	30										G	91769539	A	G	91769539	3	3	4	1	0	0	0	0	1	0	0	0	15415	188	7	5	48	5	SV2B	15	91769539	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	30849985	91769539	10761853	179	600										
MLST8	64223	broad.mit.edu	37	chr16	2256159	2256159	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	caggctacgaccacaccgtgCgcttctggcaggcccacagc	11	17	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:2256159C>G	uc002coz.2	+	2	192	c.73C>G	c.(73-75)CGC>GGC	p.R25G	MLST8_uc002coy.2_Missense_Mutation_p.R25G|MLST8_uc002cpa.2_5'UTR|MLST8_uc002cpb.2_Missense_Mutation_p.R25G|MLST8_uc010uvx.1_5'UTR|MLST8_uc002cpc.2_Missense_Mutation_p.R25G|MLST8_uc002cpd.2_5'UTR|MLST8_uc002cpe.2_Missense_Mutation_p.R25G|MLST8_uc010uvy.1_Missense_Mutation_p.R25G|MLST8_uc002cpg.2_Missense_Mutation_p.R44G|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Missense_Mutation_p.R25G	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	25	WD 1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						CCACACCGTGCGCTTCTGGCA	0.706													0	0	0	0.01441	0	46	64										G	2256159	C	G	2256159	3	3	4	1	0	0	0	0	1	0	0	0	9634	768	27	4	75	4	MLST8	16	2256159	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		2256159	88098594	180	601										
PRSS8	5652	broad.mit.edu	37	chr16	31144121	31144121	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gagaaggtgatgggtctgctGagttggaggagtgcaatgtc	18	4	1	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:31144121G>A	uc002ebc.3	-	4	752	c.420C>T	c.(418-420)CTC>CTT	p.L140L	PRSS8_uc010vfe.1_Silent_p.L86L	NM_002773	NP_002764	Q16651	PRSS8_HUMAN	prostasin preproprotein	140	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity				0						TGGGTCTGCTGAGTTGGAGGA	0.642													0	0	0	0.01441	0	279	88										A	31144121	G	A	31144121	2	1	4	1	0	0	0	0	0	0	0	1	12635	1277	45	1		1	PRSS8	16	31144121	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	28887962	31144121	59210632	181	602										
FUS	2521	broad.mit.edu	37	chr16	31202302	31202302	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agggggtaactacggggatgAtcgtcgtggtggcagaggag	20	5	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:31202302A>G	uc002ebf.2	+	14	1495	c.1412A>G	c.(1411-1413)GAT>GGT	p.D471G	FUS_uc002ebh.2_Missense_Mutation_p.D470G|FUS_uc002ebg.2_Missense_Mutation_p.D266G|FUS_uc002ebi.2_Missense_Mutation_p.D472G|FUS_uc002ebj.2_Missense_Mutation_p.D267G	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	471	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TACGGGGATGATCGTCGTGGT	0.592			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								0	0	0	0.01441	0	53	101										G	31202302	A	G	31202302	3	3	4	1	0	0	0	0	1	0	0	0	6100	333	12	5	1466	5	FUS	16	31202302	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	58181	31202302	59152451	182	603										
NUP93	9688	broad.mit.edu	37	chr16	56870618	56870618	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagaggcagcaaagctgtatGaccttgccaaggtaaagtgt	12	7	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:56870618G>A	uc002eka.2	+	17	2009	c.1888G>A	c.(1888-1890)GAC>AAC	p.D630N	NUP93_uc002ekb.2_Missense_Mutation_p.D507N|NUP93_uc010vhi.1_Missense_Mutation_p.D507N	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	630					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						AAAGCTGTATGACCTTGCCAA	0.428													0	0	0	0.028581	0	14	20										A	56870618	G	A	56870618	3	1	4	1	0	0	0	0	1	0	0	0	10772	1290	45	1	1950	1	NUP93	16	56870618	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	25668316	56870618	33484135	183	604										
SMYD4	114826	broad.mit.edu	37	chr17	1686727	1686727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgctctgcccacaggaagctCtcggcgtcacgctggcaccc	11	17	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:1686727C>G	uc002ftm.3	-	9	2232	c.2064G>C	c.(2062-2064)GAG>GAC	p.E688D	SMYD4_uc002ftn.1_Missense_Mutation_p.E543D	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	688							zinc ion binding			skin(3)|kidney(2)	5						ACAGGAAGCTCTCGGCGTCAC	0.612													0	0	0	0.00499	0	16	50										G	1686727	C	G	1686727	3	3	4	1	0	0	0	0	1	0	0	0	14824	912	32	1	362	1	SMYD4	17	1686727	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		1686727	79508483	184	605										
KIF1C	10749	broad.mit.edu	37	chr17	4910784	4910784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagcattgctggctgagatgGgggtggccgtccgggaggat	19	7	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:4910784G>A	uc002gan.1	+	16	1764	c.1438G>A	c.(1438-1440)GGG>AGG	p.G480R		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	480					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GGCTGAGATGGGGGTGGCCGT	0.607													0	0	0	0.01441	0	65	311										A	4910784	G	A	4910784	3	1	4	1	0	0	0	0	1	0	0	0	8285	1232	43	2	1492	2	KIF1C	17	4910784	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	3224057	4910784	76284426	185	606										
RABEP1	9135	broad.mit.edu	37	chr17	5257704	5257704	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agaaaggatcacaaaaaagcAgatgttgaggaagaaataaa	10	3	1	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:5257704A>G	uc002gbm.3	+	8	1238	c.1014A>G	c.(1012-1014)GCA>GCG	p.A338A	RABEP1_uc010clc.1_Silent_p.A331A|RABEP1_uc010cld.1_Silent_p.A295A|RABEP1_uc010vsw.1_Silent_p.A295A|RABEP1_uc002gbl.3_Silent_p.A338A	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	338	Potential.				apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						ACAAAAAAGCAGATGTTGAGG	0.323													0	0	0	0.006214	0	8	30										G	5257704	A	G	5257704	2	3	4	1	0	0	0	0	0	0	0	1	12961	175	7	5		5	RABEP1	17	5257704	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	346920	5257704	75937506	186	607										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:7577538C>G	uc002gim.2	-	7	937	c.743G>C	c.(742-744)CGG>CCG	p.R248P	TP53_uc002gig.1_Missense_Mutation_p.R248P|TP53_uc002gih.2_Missense_Mutation_p.R248P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116P|TP53_uc010cng.1_Missense_Mutation_p.R116P|TP53_uc002gii.1_Missense_Mutation_p.R116P|TP53_uc010cnh.1_Missense_Mutation_p.R248P|TP53_uc010cni.1_Missense_Mutation_p.R248P|TP53_uc002gij.2_Missense_Mutation_p.R248P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155P|TP53_uc002gio.2_Missense_Mutation_p.R116P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	124	21										G	7577538	C	G	7577538	3	3	4	1	0	0	0	0	1	0	0	0	16378	652	23	4	547	4	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2319834	7577538	73617672	187	608										
GUCY2D	3000	broad.mit.edu	37	chr17	7906989	7906989	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tccacggcactcagggcccgGggcctgcctgtcgcctccgt	13	18	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:7906989G>A	uc002gjt.2	+	2	698	c.624G>A	c.(622-624)CGG>CGA	p.R208R		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	208	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TCAGGGCCCGGGGCCTGCCTG	0.711													0	0	0	0.010729	0	10	52										A	7906989	G	A	7906989	2	1	4	1	0	0	0	0	0	0	0	1	6897	1219	43	2		2	GUCY2D	17	7906989	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	329451	7906989	73288221	188	609										
MYH4	4622	broad.mit.edu	37	chr17	10364372	10364372	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cccaggatgtccacagcactCtgtcaaaagagttgaatttg	9	10	2	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:10364372C>G	uc002gmn.2	-	12	1120	c.1009_splice	c.e12-1	p.S337_splice	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCACAGCACTCTGTCAAAAGA	0.463													0	0	0	0.009535	0	22	103										G	10364372	C	G	10364372	5	3	4	1	0	0	0	0	0	0	1	0	10037	927	32	1	4927	1	MYH4	17	10364372	Splice_Site	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2457383	10364372	70830838	189	610										
MYH1	4619	broad.mit.edu	37	chr17	10409366	10409366	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ttggggatgatgcaccgcacAaagtgggggtgagtgctcct	16	8	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:10409366A>G	uc002gmo.2	-	18	2113	c.2019T>C	c.(2017-2019)TTT>TTC	p.F673F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	673	Myosin head-like.|Actin-binding (By similarity).					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGCACCGCACAAAGTGGGGGT	0.423													0	0	0	0.01441	0	35	166										G	10409366	A	G	10409366	2	3	4	1	0	0	0	0	0	0	0	1	10029	127	5	5		5	MYH1	17	10409366	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	44994	10409366	70785844	190	611										
KCNJ12	3768	broad.mit.edu	37	chr17	21319580	21319580	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggtggaggccacagccatgaCcacccaggcccgcagctcct	12	17	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:21319580C>G	uc002gyv.1	+	3	1631	c.926C>G	c.(925-927)ACC>AGC	p.T309S		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	309	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	ACAGCCATGACCACCCAGGCC	0.607										Prostate(3;0.18)			0	0	0	0.027356	0	22	268										G	21319580	C	G	21319580	3	3	4	1	0	0	0	0	1	0	0	0	8046	507	18	4	928	4	KCNJ12	17	21319580	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	10910214	21319580	59875630	191	612										
HNF1B	6928	broad.mit.edu	37	chr17	36070615	36070615	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	catggcgctgttgccatggtGactgattgttgaggaggaag	16	6	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:36070615G>A	uc002hok.3	-	5	1323	c.1102C>T	c.(1102-1104)CAC>TAC	p.H368Y	HNF1B_uc010wdi.1_Missense_Mutation_p.H342Y	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	368					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TTGCCATGGTGACTGATTGTT	0.537									Hereditary_Prostate_Cancer				0	0	0	0.016522	0	21	46										A	36070615	G	A	36070615	3	1	4	1	0	0	0	0	1	0	0	0	7252	1290	45	1	591	1	HNF1B	17	36070615	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	14751035	36070615	45124595	192	613										
MED1	5469	broad.mit.edu	37	chr17	37563898	37563898	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	actctctggcttgatgctatGagattttttcttgtctcggt	9	8	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:37563898G>C	uc002hrv.3	-	17	4788	c.4576C>G	c.(4576-4578)CAT>GAT	p.H1526D	MED1_uc010wee.1_Missense_Mutation_p.H1354D|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1526	Lys-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTGATGCTATGAGATTTTTTC	0.318										HNSCC(31;0.082)			0	0	0	0.016522	0	21	83										C	37563898	G	C	37563898	3	2	4	1	0	0	0	0	1	0	0	0	9425	1290	45	1	173	1	MED1	17	37563898	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1493283	37563898	43631312	193	614										
C17orf37	84299	broad.mit.edu	37	chr17	37885818	37885818	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggctgttggtgatcttttctAgggtttctccattactggct	11	8	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:37885818A>G	uc002hsq.2	-	4	345	c.305T>C	c.(304-306)CTA>CCA	p.L102P		NM_032339	NP_115715	Q9BRT3	CQ037_HUMAN	hypothetical protein LOC84299	102					cell redox homeostasis	cytosol|membrane	selenium binding				0	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;3.72e-63)|all cancers(3;1.87e-56)|BRCA - Breast invasive adenocarcinoma(8;6.8e-45)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATCTTTTCTAGGGTTTCTCC	0.542													0	0	0	0.009718	0	40	190										G	37885818	A	G	37885818	3	3	4	1	0	0	0	0	1	0	0	0	1854	420	15	5	46	5	C17orf37	17	37885818	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	321920	37885818	43309392	194	615										
PLEKHH3	79990	broad.mit.edu	37	chr17	40823016	40823016	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggggctggacatttacttctCaaacctggtgagcacgtcgg	13	10	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:40823016C>G	uc002iau.2	-	9	1884	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	PLEKHH3_uc010cyl.1_Intron|PLEKHH3_uc002iat.1_Intron|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Intron	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	473	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		ATTTACTTCTCAAACCTGGTG	0.637													0	0	0	0.01441	0	69	252										G	40823016	C	G	40823016	3	3	4	1	0	0	0	0	1	0	0	0	12078	835	29	1	984	1	PLEKHH3	17	40823016	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2937198	40823016	40372194	195	616										
CCDC103	388389	broad.mit.edu	37	chr17	42980014	42980015	+	Frame_Shift_Del	DEL	AG	AG	-													0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctaagcctgctgagccgggcAgagagagagagctgcaaggg							TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:42980014_42980015delAG	uc002iho.2	+	4	641_642	c.558_559delAG	c.(556-561)GCAGAGfs	p.A186fs	CCDC103_uc002ihp.1_5'Flank	NM_213607	NP_998772	Q8IW40	CC103_HUMAN	coiled-coil domain containing 103	186_187										kidney(1)	1		Prostate(33;0.109)				TGAGCCGGGCAGAGAGAGAGAG	0.644																		11	116	---	---								-	42980015	AG	-	42980014	7	5	4	1	0	1	0	1	0	0	0	0	2738	175	7	0	568	0	CCDC103	17	42980014	Frame_Shift_Del	DEL	AG	TCGA-BL-A3JM-01A-12D-A21A-08	2156998	42980014	38215196	196	617										
DCAF7	10238	broad.mit.edu	37	chr17	61628110	61628110	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	acagtctacgcgatgaactgGagtgtgcggcccgataagcg	14	10	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:61628110G>C	uc002jbc.2	+	1	289	c.72G>C	c.(70-72)TGG>TGC	p.W24C	DCAF7_uc002jbb.2_RNA|DCAF7_uc010wpn.1_Missense_Mutation_p.W24C	NM_005828	NP_005819	P61962	DCAF7_HUMAN	WD-repeat protein	24					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			ovary(1)	1						CGATGAACTGGAGTGTGCGGC	0.642													0	0	0	0.027356	0	28	97										C	61628110	G	C	61628110	3	2	4	1	0	0	0	0	1	0	0	0	4275	1183	41	1	74	1	DCAF7	17	61628110	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	18648096	61628110	19567100	197	618										
ABCA8	10351	broad.mit.edu	37	chr17	66913593	66913593	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggagagaaatactttcctgtCtgaaaaagaagaagagcaaa	10	5	1	5			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:66913593C>T	uc002jhp.2	-	15	2107	c.1928_splice	c.e15-1	p.D643_splice	ABCA8_uc002jhq.2_Splice_Site_p.D683_splice|ABCA8_uc010wqq.1_Splice_Site_p.D683_splice|ABCA8_uc010wqr.1_Splice_Site_p.D622_splice|ABCA8_uc002jhr.2_Splice_Site_p.D683_splice	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ACTTTCCTGTCTGAAAAAGAA	0.373													0	0	0	0.007413	0	19	66										T	66913593	C	T	66913593	5	4	4	1	0	0	0	0	0	0	1	0	38	927	32	1	2914	1	ABCA8	17	66913593	Splice_Site	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	5285483	66913593	14281617	198	619										
PYCR1	5831	broad.mit.edu	37	chr17	79892301	79892301	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ggatggtggccccaccaggaGagctgacgttgtccttgagc	15	11	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:79892301G>A	uc002kcr.1	-	6	976	c.698C>T	c.(697-699)TCT>TTT	p.S233F	PYCR1_uc002kcq.1_Intron|PYCR1_uc002kcp.2_Missense_Mutation_p.S233F|PYCR1_uc002kcs.1_Intron|PYCR1_uc010wvd.1_Missense_Mutation_p.S260F|PYCR1_uc002kct.1_Missense_Mutation_p.S233F|PYCR1_uc002kcu.1_Missense_Mutation_p.S202F|PYCR1_uc010wve.1_Missense_Mutation_p.S154F	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	233					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	CCCACCAGGAGAGCTGACGTT	0.637													0	0	0	0.014758	0	5	40										A	79892301	G	A	79892301	3	1	4	1	0	0	0	0	1	0	0	0	12855	942	33	1	357	1	PYCR1	17	79892301	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	12978708	79892301	1302909	199	620										
DUS1L	64118	broad.mit.edu	37	chr17	80017896	80017896	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cttgttcttggacaggacctCcgtgccaccctcctcttcct	7	17	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:80017896C>T	uc002kdq.2	-	10	1515	c.1096G>A	c.(1096-1098)GAG>AAG	p.E366K	DUS1L_uc002kdp.2_Missense_Mutation_p.E235K|DUS1L_uc002kdr.2_Missense_Mutation_p.E366K|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	366					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GACAGGACCTCCGTGCCACCC	0.652													0	0	0	0.021523	0	23	102										T	80017896	C	T	80017896	3	4	4	1	0	0	0	0	1	0	0	0	4805	864	30	1	341	1	DUS1L	17	80017896	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	125595	80017896	1177314	200	621										
USP14	9097	broad.mit.edu	37	chr18	179002	179002	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cctcagccaaaactgtcttcGtagaagacatgacagaagaa	8	10	2	5	rs141269921	by1000genomes	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:179002G>A	uc002kkf.1	+	4	481	c.265G>A	c.(265-267)GTA>ATA	p.V89I	USP14_uc002kkg.1_Intron|USP14_uc010wyr.1_Missense_Mutation_p.V78I	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	89					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				AACTGTCTTCGTAGAAGACAT	0.373													0	0	0	0.010818	0	25	22										A	179002	G	A	179002	3	1	4	1	0	0	0	0	1	0	0	0	17042	1145	40	2	279	2	USP14	18	179002	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		179002	77898246	201	622										
L3MBTL4	91133	broad.mit.edu	37	chr18	6301906	6301906	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tattggtgataattaccgtgActcaaaggggttgtgctatc	11	6	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:6301906A>C	uc002kmz.3	-	4	283	c.123T>G	c.(121-123)AGT>AGG	p.S41R	L3MBTL4_uc010dkt.2_Missense_Mutation_p.S41R	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	41					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				AATTACCGTGACTCAAAGGGG	0.338													0	0	0	0.012213	0	25	118										C	6301906	A	C	6301906	3	2	4	1	0	0	0	0	1	0	0	0	8594	272	10	5	1816	5	L3MBTL4	18	6301906	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	6122904	6301906	71775342	202	623										
ANKRD12	23253	broad.mit.edu	37	chr18	9281059	9281059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ataaatctatcagcatttacGaaatccaggagttttatgtt	6	6	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:9281059G>A	uc002knv.2	+	13	6381	c.6124G>A	c.(6124-6126)GAA>AAA	p.E2042K	ANKRD12_uc002knw.2_Missense_Mutation_p.E2019K|ANKRD12_uc002knx.2_Missense_Mutation_p.E2019K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	2042						nucleus				ovary(2)|central_nervous_system(1)	3						CAGCATTTACGAAATCCAGGA	0.418													0	0	0	0.01441	0	48	79										A	9281059	G	A	9281059	3	1	4	1	0	0	0	0	1	0	0	0	640	1059	37	1	6170	1	ANKRD12	18	9281059	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2979153	9281059	68796189	203	624										
CELF4	56853	broad.mit.edu	37	chr18	34901838	34901838	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aggcttcacctggatcggccGgttcatctgcaacagagcag	12	12	3	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:34901838G>A	uc002lae.2	-	3	772	c.376C>T	c.(376-378)CGG>TGG	p.R126W	CELF4_uc010dnd.1_Missense_Mutation_p.R126W|CELF4_uc002lag.2_Missense_Mutation_p.R126W|CELF4_uc002laf.2_Missense_Mutation_p.R122W|CELF4_uc002lai.2_Missense_Mutation_p.R122W	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	126	RRM 1.|Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGGATCGGCCGGTTCATCTGC	0.597											OREG0024927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	41	67										A	34901838	G	A	34901838	3	1	4	1	0	0	0	0	1	0	0	0	3218	1115	39	2	1124	2	CELF4	18	34901838	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	25620779	34901838	43175410	204	625										
DSEL	92126	broad.mit.edu	37	chr18	65180301	65180301	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cattctcccagttgaccttcCcagggcttattacactggct	7	14	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:65180301C>T	uc002lke.1	-	2	2799	c.1575G>A	c.(1573-1575)TGG>TGA	p.W525*		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	515						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GTTGACCTTCCCAGGGCTTAT	0.488													0	0	0	0.019004	0	33	75										T	65180301	C	T	65180301	4	4	4	1	0	0	0	0	0	1	0	0	4775	624	22	2	2097	2	DSEL	18	65180301	Nonsense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	30278463	65180301	12896947	205	626										
CSNK1G2	1455	broad.mit.edu	37	chr19	1978971	1978971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagcatgccatccacatcatCgacttcgggctggccaagga	10	14	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:1978971C>G	uc002lul.3	+	7	1084	c.561C>G	c.(559-561)ATC>ATG	p.I187M	CSNK1G2_uc010dsu.2_Missense_Mutation_p.I139M	NM_001319	NP_001310	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	187	Protein kinase.				sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			stomach(1)	1		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCACATCATCGACTTCGGGC	0.617													0	0	0	0.027894	0	35	82										G	1978971	C	G	1978971	3	3	4	1	0	0	0	0	1	0	0	0	3955	874	31	1	579	1	CSNK1G2	19	1978971	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		1978971	57150012	206	627										
AES	166	broad.mit.edu	37	chr19	3053861	3053861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctcctggtgggtgtcaccatCgtgcccgttcttgtcttcct	10	14	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:3053861C>T	uc002lwy.1	-	7	723	c.550G>A	c.(550-552)GAT>AAT	p.D184N	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.D183N|AES_uc002lxa.1_Missense_Mutation_p.D128N|AES_uc002lxb.1_Missense_Mutation_p.D251N|AES_uc002lxc.2_Missense_Mutation_p.R277Q	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	184	CCN domain.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTCACCATCGTGCCCGTTC	0.682													0	0	0	0.024334	0	19	83										T	3053861	C	T	3053861	3	4	4	1	0	0	0	0	1	0	0	0	352	884	31	1	47	1	AES	19	3053861	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1074890	3053861	56075122	207	628										
PLIN3	10226	broad.mit.edu	37	chr19	4852049	4852049	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagttcggcatccgtaagggGcaggtggttgtccgcccact	14	12	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:4852049G>A	uc002mbj.2	-	5	790	c.613C>T	c.(613-615)CCC>TCC	p.P205S	PLIN3_uc002mbk.2_Missense_Mutation_p.P193S|PLIN3_uc002mbl.3_Missense_Mutation_p.P205S	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	205					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TCCGTAAGGGGCAGGTGGTTG	0.682											OREG0025175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	18	81										A	4852049	G	A	4852049	3	1	4	1	0	0	0	0	1	0	0	0	12091	1203	42	2	707	2	PLIN3	19	4852049	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1798188	4852049	54276934	208	629										
GPR108	56927	broad.mit.edu	37	chr19	6731901	6731901	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cctgcaggcgcagggcctcaCccttcccgtctgtgccagac	11	18	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:6731901C>T	uc002mfp.2	-	14	1346	c.1300_splice	c.e14+1	p.V434_splice	GPR108_uc010duv.2_Intron|GPR108_uc002mfn.2_Splice_Site_p.V105_splice|GPR108_uc002mfo.3_Splice_Site_p.V192_splice|GPR108_uc010duw.2_Splice_Site	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1							integral to membrane					0						CAGGGCCTCACCCTTCCCGTC	0.662													0	0	0	0.020292	0	13	1										T	6731901	C	T	6731901	5	4	4	1	0	0	0	0	0	0	1	0	6624	521	18	2	350	2	GPR108	19	6731901	Splice_Site	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1879852	6731901	52397082	209	630										
CLEC4M	10332	broad.mit.edu	37	chr19	7833781	7833781	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agcgggaatgaagactgtgcGgaatttagtggcagtggctg	17	5	0	2	rs144974332		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:7833781G>A	uc002mih.2	+	8	1156	c.1038G>A	c.(1036-1038)GCG>GCA	p.A346A	CLEC4M_uc010xjw.1_Silent_p.A302A|CLEC4M_uc010dvt.2_Silent_p.A323A|CLEC4M_uc010dvs.2_Silent_p.A345A|CLEC4M_uc010xjx.1_Silent_p.A318A|CLEC4M_uc002mhz.2_3'UTR|CLEC4M_uc002mic.2_3'UTR|CLEC4M_uc002mia.2_Silent_p.A233A	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	369	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						AAGACTGTGCGGAATTTAGTG	0.512													0	0	0	0.00499	0	14	148										A	7833781	G	A	7833781	2	1	4	1	0	0	0	0	0	0	0	1	3518	1103	39	2		2	CLEC4M	19	7833781	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	1101880	7833781	51295202	210	631										
EVI5L	115704	broad.mit.edu	37	chr19	7918186	7918186	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aaggagtacgcagccatgaaGagcaaggagatggaggagca	16	6	0	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:7918186G>C	uc002min.2	+	10	1267	c.1113G>C	c.(1111-1113)AAG>AAC	p.K371N	EVI5L_uc010xjz.1_Missense_Mutation_p.K371N|EVI5L_uc002mio.1_Missense_Mutation_p.K102N	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	371	Potential.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CAGCCATGAAGAGCAAGGAGA	0.627											OREG0025211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	15										C	7918186	G	C	7918186	3	2	4	1	0	0	0	0	1	0	0	0	5290	933	33	1	1147	1	EVI5L	19	7918186	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	84405	7918186	51210797	211	632										
MUC16	94025	broad.mit.edu	37	chr19	9017366	9017366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cattgacatagagactgttcCtgtccagggtgtaggggccc	13	10	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9017366C>T	uc002mkp.2	-	26	38162	c.37958G>A	c.(37957-37959)AGG>AAG	p.R12653K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12655	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGACTGTTCCTGTCCAGGGT	0.567													0	0	0	0.01441	0	259	52										T	9017366	C	T	9017366	3	4	4	1	0	0	0	0	1	0	0	0	9973	681	24	2	5801	2	MUC16	19	9017366	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	1099180	9017366	50111617	212	633										
MUC16	94025	broad.mit.edu	37	chr19	9072253	9072253	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagtgaagtcataggagaggAgagcttatcctctggtaagg	14	5	2	3			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9072253A>C	uc002mkp.2	-	3	15397	c.15193T>G	c.(15193-15195)TCC>GCC	p.S5065A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5067	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S5065Y(1)		lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATAGGAGAGGAGAGCTTATCC	0.478													0	0	0	0.01441	0	65	18										C	9072253	A	C	9072253	3	2	4	1	0	0	0	0	1	0	0	0	9973	304	11	5	28658	5	MUC16	19	9072253	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	54887	9072253	50056730	213	634										
OR7G2	390882	broad.mit.edu	37	chr19	9213857	9213857	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aaaaggacgggctgcagttcCggatcctctatcagtcccag	11	12	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9213857C>T	uc010xkk.1	-	1	126	c.126G>A	c.(124-126)CCG>CCA	p.P42P		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTGCAGTTCCGGATCCTCTA	0.468													0	0	0	0.017118	0	30	94										T	9213857	C	T	9213857	2	4	4	1	0	0	0	0	0	0	0	1	11223	639	23	2		2	OR7G2	19	9213857	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	141604	9213857	49915126	214	635										
ZNF426	79088	broad.mit.edu	37	chr19	9639507	9639507	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcaaatgtccactaagatttGaggaaactgcaaaggctttc	8	8	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9639507G>A	uc002mlq.2	-	8	1478	c.1214C>T	c.(1213-1215)TCA>TTA	p.S405L	ZNF426_uc010dws.2_Missense_Mutation_p.S367L	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	405	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACTAAGATTTGAGGAAACTGC	0.408													0	0	0	0.004482	0	8	27										A	9639507	G	A	9639507	3	1	4	1	0	0	0	0	1	0	0	0	17897	1294	45	1	454	1	ZNF426	19	9639507	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	425650	9639507	49489476	215	636										
FCHO1	23149	broad.mit.edu	37	chr19	17892531	17892531	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ccacccccaggagtctcccgGggtccgagccctgtggtcct	12	18	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:17892531G>A	uc010ebb.2	+	22	2028	c.1839G>A	c.(1837-1839)CGG>CGA	p.R613R	FCHO1_uc002nhg.3_Silent_p.R613R|FCHO1_uc002nhh.2_Silent_p.R613R|FCHO1_uc010xpw.1_Silent_p.R563R|FCHO1_uc002nhi.2_Silent_p.R69R|FCHO1_uc002nhj.2_5'UTR	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	613										breast(1)	1						GAGTCTCCCGGGGTCCGAGCC	0.627													0	0	0	0.01441	0	214	45										A	17892531	G	A	17892531	2	1	4	1	0	0	0	0	0	0	0	1	5787	1219	43	2		2	FCHO1	19	17892531	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	8253024	17892531	41236452	216	637										
KIAA1683	80726	broad.mit.edu	37	chr19	18378205	18378206	+	Frame_Shift_Del	DEL	TC	TC	-													0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctggggctgtggaggcgcttTctccattttgtccaggagac							TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:18378205_18378206delTC	uc002nin.2	-	3	360_361	c.144_145delGA	c.(142-147)GAGAAAfs	p.E48fs	KIAA1683_uc010ebn.2_Frame_Shift_Del_p.E48fs|KIAA1683_uc010xqe.1_Frame_Shift_Del_p.E2fs	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	48_49						mitochondrion				ovary(2)	2						GGAGGCGCTTTCTCCATTTTGT	0.653																		64	163	---	---								-	18378206	TC	-	18378205	7	5	4	1	0	1	0	1	0	0	0	0	8251	1792	62	0	3966	0	KIAA1683	19	18378205	Frame_Shift_Del	DEL	TC	TCGA-BL-A3JM-01A-12D-A21A-08	485674	18378205	40750778	217	638										
KIAA1683	80726	broad.mit.edu	37	chr19	18378333	18378333	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gattaccggacaggtcagctCtgcctgtgggggcggcaggg	18	10	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:18378333C>G	uc002nin.2	-	3	233	c.17G>C	c.(16-18)AGA>ACA	p.R6T	KIAA1683_uc010ebn.2_Missense_Mutation_p.R6T|KIAA1683_uc010xqe.1_5'UTR	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	6						mitochondrion				ovary(2)	2						CAGGTCAGCTCTGCCTGTGGG	0.652													0	0	0	0.01441	0	88	177										G	18378333	C	G	18378333	3	3	4	1	0	0	0	0	1	0	0	0	8251	913	32	1	4094	1	KIAA1683	19	18378333	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	128	18378333	40750650	218	639										
ZNF626	199777	broad.mit.edu	37	chr19	20807986	20807986	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cttaaaggctttgccacattCttcacatttgtagggtttct	7	9	3	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:20807986C>G	uc002npb.1	-	4	847	c.697G>C	c.(697-699)GAA>CAA	p.E233Q	ZNF626_uc002npc.1_Missense_Mutation_p.E157Q	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	233	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTGCCACATTCTTCACATTTG	0.398													0	0	0	0.020292	0	11	41										G	20807986	C	G	20807986	3	3	4	1	0	0	0	0	1	0	0	0	18047	922	32	1	893	1	ZNF626	19	20807986	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	2429653	20807986	38320997	219	640										
ZNF536	9745	broad.mit.edu	37	chr19	31039640	31039640	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gataacaccatcggggtcacAgtcaactgcaaagaccaagc	9	12	2	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:31039640A>G	uc002nsu.1	+	4	3252	c.3114A>G	c.(3112-3114)ACA>ACG	p.T1038T	ZNF536_uc010edd.1_Silent_p.T1038T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCGGGGTCACAGTCAACTGCA	0.537													0	0	0	0.015359	0	32	104										G	31039640	A	G	31039640	2	3	4	1	0	0	0	0	0	0	0	1	17971	175	7	5		5	ZNF536	19	31039640	Silent	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08	10231654	31039640	28089343	220	641										
PRX	57716	broad.mit.edu	37	chr19	40909668	40909668	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcctcgcgcagctcccgaacGaagattccctctttgccgcc	8	18	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:40909668G>A	uc002onr.2	-	5	398	c.129C>T	c.(127-129)TTC>TTT	p.F43F	PRX_uc002onq.2_5'UTR|PRX_uc002ons.2_Silent_p.F43F	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	43	PDZ.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTCCCGAACGAAGATTCCCT	0.701													0	0	0	0.021553	0	5	15										A	40909668	G	A	40909668	2	1	4	1	0	0	0	0	0	0	0	1	12642	1049	37	1		1	PRX	19	40909668	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	9870028	40909668	18219315	221	642										
PNMAL2	57469	broad.mit.edu	37	chr19	46997598	46997598	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tccttggacatgacggacaaGacctgtcggagggggtctcg	15	10	1	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:46997598G>A	uc002pes.2	-	1	1572	c.1125C>T	c.(1123-1125)GTC>GTT	p.V375V	uc002peu.1_5'Flank	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	375										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TGACGGACAAGACCTGTCGGA	0.642													0	0	0	0.004482	0	8	41										A	46997598	G	A	46997598	2	1	4	1	0	0	0	0	0	0	0	1	12158	929	33	1		1	PNMAL2	19	46997598	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	6087930	46997598	12131385	222	643										
PTGIR	5739	broad.mit.edu	37	chr19	47124612	47124612	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	ctgccgctggactgctgtgtGggaggcaagggctccacctg	16	12	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:47124612G>A	uc002pex.2	-	3	1199	c.1086C>T	c.(1084-1086)CCC>CCT	p.P362P		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	362	Cytoplasmic (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	ACTGCTGTGTGGGAGGCAAGG	0.657													0	0	0	0.01441	0	53	15										A	47124612	G	A	47124612	2	1	4	1	0	0	0	0	0	0	0	1	12751	1335	47	2		2	PTGIR	19	47124612	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	127014	47124612	12004371	223	644										
DBP	1628	broad.mit.edu	37	chr19	49136903	49136903	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cagggctgggtgtgtcccgaGaggtcaggccttggggaaac	18	9	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:49136903G>A	uc002pjx.3	-	3	948	c.560C>T	c.(559-561)TCT>TTT	p.S187F	DBP_uc002pjy.2_3'UTR|DBP_uc010elz.1_Missense_Mutation_p.S187F	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	187					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		TGTGTCCCGAGAGGTCAGGCC	0.542													0	0	0	0.009535	0	29	81										A	49136903	G	A	49136903	3	1	4	1	0	0	0	0	1	0	0	0	4256	942	33	1	425	1	DBP	19	49136903	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2012291	49136903	9992080	224	645										
GPR32	2854	broad.mit.edu	37	chr19	51274466	51274466	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tctgacaatgagactgcccaGatttggattgaaggggtcgt	13	7	1	4			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:51274466G>C	uc010ycf.1	+	1	609	c.609G>C	c.(607-609)CAG>CAC	p.Q203H		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	203	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGACTGCCCAGATTTGGATTG	0.552													0	0	0	0.01441	0	57	13										C	51274466	G	C	51274466	3	2	4	1	0	0	0	0	1	0	0	0	6688	933	33	1	611	1	GPR32	19	51274466	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	2137563	51274466	7854517	225	646										
UBE2M	9040	broad.mit.edu	37	chr19	59069644	59069644	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tcccctgaccccctacccttCtggatccgcagctgcgccgc	8	21	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:59069644C>T	uc002qtl.3	-	1	700	c.105G>A	c.(103-105)CAG>CAA	p.Q35Q	LOC100131691_uc002qtm.2_5'Flank	NM_003969	NP_003960	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	35	Interaction with UBA3.			Q->A: Strongly impairs thioester intermediate formation.	protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCTACCCTTCTGGATCCGCA	0.647													0	0	0	0.008871	0	17	58										T	59069644	C	T	59069644	2	4	4	1	0	0	0	0	0	0	0	1	16862	912	32	1		1	UBE2M	19	59069644	Silent	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08	7795178	59069644	59339	226	647										
PANK2	80025	broad.mit.edu	37	chr20	3870313	3870313	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gaggcgggatcgactgggctCttacagcggccccacctcgg	15	14	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:3870313C>G	uc002wkc.2	+	1	572	c.566C>G	c.(565-567)TCT>TGT	p.S189C	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	189					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						CGACTGGGCTCTTACAGCGGC	0.751													0	0	0	0.00308	0	6	38										G	3870313	C	G	3870313	3	3	4	1	0	0	0	0	1	0	0	0	11417	913	32	1	568	1	PANK2	20	3870313	Missense_Mutation	SNP	C	TCGA-BL-A3JM-01A-12D-A21A-08		3870313	59155207	227	648										
C20orf26	26074	broad.mit.edu	37	chr20	20051628	20051628	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgtcagtgttccgggagctcGacagtgacatcccatgcaca	11	12	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:20051628G>T	uc002wru.2	+	3	350	c.274G>T	c.(274-276)GAC>TAC	p.D92Y	C20orf26_uc010gcw.1_Missense_Mutation_p.D46Y|C20orf26_uc010zse.1_Missense_Mutation_p.D92Y|C20orf26_uc010zsf.1_Missense_Mutation_p.D92Y	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	92										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCGGGAGCTCGACAGTGACAT	0.498													1	0	6.05902e-23	0.017118	6.64387e-23	28	136										T	20051628	G	T	20051628	3	4	4	1	0	0	0	0	1	0	0	0	2106	1058	37	3	280	3	C20orf26	20	20051628	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	16181315	20051628	42973892	228	649										
KCNS1	3787	broad.mit.edu	37	chr20	43727083	43727083	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aagtgcagcaggctcaggaaGaagcccgggtgccggtcgaa	16	10	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:43727083G>A	uc002xnc.2	-	4	727	c.330C>T	c.(328-330)TTC>TTT	p.F110F	KCNS1_uc002xnd.2_Silent_p.F110F	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	110	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				GGCTCAGGAAGAAGCCCGGGT	0.692													0	0	0	0.024245	0	11	11										A	43727083	G	A	43727083	2	1	4	1	0	0	0	0	0	0	0	1	8088	933	33	1		1	KCNS1	20	43727083	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	23675455	43727083	19298437	229	650										
ZNF335	63925	broad.mit.edu	37	chr20	44596540	44596540	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aggctgggggcagctgcaccGgggagctgggcccaccctgt	18	13	0	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:44596540G>A	uc002xqw.2	-	5	770	c.647C>T	c.(646-648)CCG>CTG	p.P216L	ZNF335_uc010zxk.1_Missense_Mutation_p.P61L|ZNF335_uc002xqx.1_Missense_Mutation_p.P184L|ZNF335_uc002xqy.2_Missense_Mutation_p.P61L	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				CAGCTGCACCGGGGAGCTGGG	0.647													0	0	0	0.021022	0	36	121										A	44596540	G	A	44596540	3	1	4	1	0	0	0	0	1	0	0	0	17849	1116	39	2	3477	2	ZNF335	20	44596540	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	869457	44596540	18428980	230	651										
PSMA7	5688	broad.mit.edu	37	chr20	60712444	60712444	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	agggattgatctcgcctcatGacagcaagttcaatgttttt	9	8	3	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:60712444G>A	uc002ybx.1	-	6	745	c.630C>T	c.(628-630)GTC>GTT	p.V210V	PSMA7_uc002yby.1_RNA	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	210					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CTCGCCTCATGACAGCAAGTT	0.463											OREG0026105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	125	75										A	60712444	G	A	60712444	2	1	4	1	0	0	0	0	0	0	0	1	12672	1277	45	1		1	PSMA7	20	60712444	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	16115904	60712444	2313076	231	652										
TPTE	7179	broad.mit.edu	37	chr21	10934109	10934109	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	atggaagtgcttaggatcgtAagctctttcacctaaaataa	8	7	2	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr21:10934109A>C	uc002yip.1	-	16	1236	c.868T>G	c.(868-870)TAC>GAC	p.Y290D	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.Y272D|TPTE_uc002yir.1_Missense_Mutation_p.Y252D|TPTE_uc010gkv.1_Missense_Mutation_p.Y152D	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	290	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTAGGATCGTAAGCTCTTTCA	0.303													0	0	0	0.024245	0	14	74										C	10934109	A	C	10934109	3	2	4	1	0	0	0	0	1	0	0	0	16427	362	13	5	823	5	TPTE	21	10934109	Missense_Mutation	SNP	A	TCGA-BL-A3JM-01A-12D-A21A-08		10934109	37195786	232	653										
TMPRSS2	7113	broad.mit.edu	37	chr21	42860419	42860419	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aggagtcgcactctatcccaGagttggagcacttgctgccc	11	13	1	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr21:42860419G>C	uc002yzj.2	-	5	481	c.347C>G	c.(346-348)TCT>TGT	p.S116C	TMPRSS2_uc010gor.2_Missense_Mutation_p.S153C|TMPRSS2_uc010gos.1_Missense_Mutation_p.S116C	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	116	Extracellular (Potential).|LDL-receptor class A.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CTCTATCCCAGAGTTGGAGCA	0.527			T	ERG|ETV1|ETV4|ETV5	prostate 								0	0	0	0.021022	0	38	12										C	42860419	G	C	42860419	3	2	4	1	0	0	0	0	1	0	0	0	16244	942	33	1	1171	1	TMPRSS2	21	42860419	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	31926310	42860419	5269476	233	654										
KLHL22	84861	broad.mit.edu	37	chr22	20812254	20812254	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	tgctcctgctgcagggactgGatctggaaccagcggttgtg	15	10	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr22:20812254G>C	uc002zsl.1	-	5	1255	c.1146C>G	c.(1144-1146)ATC>ATG	p.I382M	KLHL22_uc011ahr.1_Missense_Mutation_p.I239M|KLHL22_uc002zsm.1_Missense_Mutation_p.I382M	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	382	Kelch 2.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCAGGGACTGGATCTGGAACC	0.602													0	0	0	0.013726	0	24	46										C	20812254	G	C	20812254	3	2	4	1	0	0	0	0	1	0	0	0	8377	1164	41	1	770	1	KLHL22	22	20812254	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		20812254	30492312	234	655										
MED15	51586	broad.mit.edu	37	chr22	20909319	20909319	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cccgggacagtctctgggcgGgatgggtagccttggtgcca	17	11	1	0			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr22:20909319G>A	uc002zsp.2	+	5	415	c.335G>A	c.(334-336)GGG>GAG	p.G112E	MED15_uc002zsn.1_Missense_Mutation_p.G31E|MED15_uc002zso.2_Intron|MED15_uc002zsq.2_Missense_Mutation_p.G112E|MED15_uc010gso.2_Missense_Mutation_p.G112E|MED15_uc002zsr.2_Missense_Mutation_p.G86E|MED15_uc011ahs.1_Missense_Mutation_p.G86E|MED15_uc011aht.1_Missense_Mutation_p.G86E|MED15_uc002zss.2_Missense_Mutation_p.G31E	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	112					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TCTCTGGGCGGGATGGGTAGC	0.647													0	0	0	0.009096	0	3	58										A	20909319	G	A	20909319	3	1	4	1	0	0	0	0	1	0	0	0	9433	1232	43	2	353	2	MED15	22	20909319	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	97065	20909319	30395247	235	656										
DEPDC5	9681	broad.mit.edu	37	chr22	32275583	32275583	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	cgccagcttccagcgcaagtGgtttgaggtggcctttgtgg	15	10	0	1			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr22:32275583G>A	uc003als.2	+	37	3927	c.3785G>A	c.(3784-3786)TGG>TAG	p.W1262*	DEPDC5_uc011als.1_Nonsense_Mutation_p.W1193*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.W1293*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.W1284*|DEPDC5_uc003alu.2_Nonsense_Mutation_p.W711*|DEPDC5_uc003alv.2_RNA|DEPDC5_uc003alw.2_Nonsense_Mutation_p.W560*|DEPDC5_uc011alx.1_Nonsense_Mutation_p.W110*|DEPDC5_uc010gwk.2_Nonsense_Mutation_p.W288*|DEPDC5_uc011aly.1_Nonsense_Mutation_p.W110*	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1262					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CAGCGCAAGTGGTTTGAGGTG	0.612													0	0	0	0.01441	0	71	35										A	32275583	G	A	32275583	4	1	4	1	0	0	0	0	0	1	0	0	4442	1357	47	2	4015	2	DEPDC5	22	32275583	Nonsense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	11366264	32275583	19028983	236	657										
HUWE1	10075	broad.mit.edu	37	chrX	53672365	53672365	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	aatacatataggagattgagGactgccagcaccacttgcat	9	9	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chrX:53672365G>A	uc004dsp.2	-	7	804	c.402C>T	c.(400-402)GTC>GTT	p.V134V		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	134					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GGAGATTGAGGACTGCCAGCA	0.458													0	0	0	0.008871	0	17	8										A	53672365	G	A	53672365	2	1	4	1	0	0	0	0	0	0	0	1	7461	1161	41	1		1	HUWE1	23	53672365	Silent	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08		53672365	101598195	237	658										
TAZ	6901	broad.mit.edu	37	chrX	153648555	153648555	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.34453781512605	82	7.09114356844357e-28	3.79196910910205	5.52702619414484	3.04409967589395	0.175779395637683	0.321849597646462	60	gtccactgtgctgcaggaatGaatgacgtccttcctaacag	10	11	0	2			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chrX:153648555G>A	uc004fkx.2	+	9	955	c.651G>A	c.(649-651)ATG>ATA	p.M217I	TAZ_uc004fky.2_Missense_Mutation_p.M203I|TAZ_uc004fkz.2_RNA|TAZ_uc004fla.2_Missense_Mutation_p.M187I|TAZ_uc004flb.2_Missense_Mutation_p.M173I|TAZ_uc010nuy.2_Missense_Mutation_p.M221I|TAZ_uc004flc.3_Missense_Mutation_p.M187I	NM_000116	NP_000107	Q16635	TAZ_HUMAN	tafazzin isoform 1	217					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCAGGAATGAATGACGTCC	0.637													0	0	0	0.01441	0	186	52										A	153648555	G	A	153648555	3	1	4	1	0	0	0	0	1	0	0	0	15593	1290	45	1	685	1	TAZ	23	153648555	Missense_Mutation	SNP	G	TCGA-BL-A3JM-01A-12D-A21A-08	99976190	153648555	1622005	238	659										
KIAA0319L	79932	broad.mit.edu	37	chr1	35919962	35919962	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	aaccacaaggctggagcttaCcaggttgcacaataacagtc	9	11	0	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:35919962C>G	uc001byx.2	-	11	2038	c.1780_splice	c.e11+1	p.E594_splice	KIAA0319L_uc001byw.2_Splice_Site_p.E31_splice|KIAA0319L_uc010ohv.1_Splice_Site_p.E236_splice	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like							cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTGGAGCTTACCAGGTTGCAC	0.498													0	0	0	0.043863	0	16	96										G	35919962	C	G	35919962	5	3	5	1	0	0	0	0	0	0	1	0	8169	521	18	4	1412	4	KIAA0319L	1	35919962	Splice_Site	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		35919962	213330659	1	660										
GBP7	388646	broad.mit.edu	37	chr1	89637586	89637586	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ttagtgttctcagtgaggcaCactgggcctggcatgtggat	14	8	1	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:89637586C>A	uc001dna.2	-	2	172	c.33G>T	c.(31-33)GTG>GTT	p.V11V		NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	11						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		CAGTGAGGCACACTGGGCCTG	0.483													1	0	0.000274275	0.047766	0.000287547	8	191										A	89637586	C	A	89637586	2	1	5	1	0	0	0	0	0	0	0	1	6279	465	17	4		4	GBP7	1	89637586	Silent	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	53717624	89637586	159613035	2	661										
AMY2B	280	broad.mit.edu	37	chr1	104117881	104117881	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tggggtttcatgccttctgaCagagcacttgtctttgtgga	12	8	3	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:104117881C>A	uc001duq.2	+	8	1531	c.915C>A	c.(913-915)GAC>GAA	p.D305E	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.D305E|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	305					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TGCCTTCTGACAGAGCACTTG	0.413													1	0	3.79751e-50	0.048971	4.57108e-50	116	233										A	104117881	C	A	104117881	3	1	5	1	0	0	0	0	1	0	0	0	595	477	17	4	937	4	AMY2B	1	104117881	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	14480295	104117881	145132740	3	662										
C1orf103	55791	broad.mit.edu	37	chr1	111495013	111495013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tggaagactctgggtattaaCtacaataaaagatgagtctt	9	5	2	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:111495013C>T	uc001eaa.2	-	2	749	c.493G>A	c.(493-495)GTT>ATT	p.V165I	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		TGGGTATTAACTACAATAAAA	0.418													0	0	0	0.069234	0	10	66										T	111495013	C	T	111495013	3	4	5	1	0	0	0	0	1	0	0	0	1977	565	20	2	1828	2	C1orf103	1	111495013	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	7377132	111495013	137755608	4	663										
RSBN1	54665	broad.mit.edu	37	chr1	114308928	114308928	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	aagccttatatgccaggctaAgctgcacaccgccgaaactg	9	13	0	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:114308928A>G	uc001edq.2	-	7	2119	c.2083T>C	c.(2083-2085)TTA>CTA	p.L695L	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	695						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCCAGGCTAAGCTGCACACC	0.428													0	0	0	0.020292	0	15	131										G	114308928	A	G	114308928	2	3	5	1	0	0	0	0	0	0	0	1	13696	69	3	5		5	RSBN1	1	114308928	Silent	SNP	A	TCGA-BT-A0S7-01A-11D-A10S-08	2813915	114308928	134941693	5	664										
HMCN1	83872	broad.mit.edu	37	chr1	186143685	186143685	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tgggacccatcagtgcagatAtaaccagatatgtgagaata	10	7	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:186143685A>G	uc001grq.1	+	103	16083	c.15854A>G	c.(15853-15855)TAT>TGT	p.Y5285C	HMCN1_uc001grs.1_Missense_Mutation_p.Y854C	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5285	EGF-like 5; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAGTGCAGATATAACCAGATA	0.408													0	0	0	0.09319	0	11	66										G	186143685	A	G	186143685	3	3	5	1	0	0	0	0	1	0	0	0	7220	449	16	5	16264	5	HMCN1	1	186143685	Missense_Mutation	SNP	A	TCGA-BT-A0S7-01A-11D-A10S-08	71834757	186143685	63106936	6	665										
OBSCN	84033	broad.mit.edu	37	chr1	228444535	228444535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ggctgtgggctgcacacggaGgctggtggtgcagcaggcgg	21	9	0	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:228444535G>A	uc009xez.1	+	15	4537	c.4493G>A	c.(4492-4494)AGG>AAG	p.R1498K	OBSCN_uc001hsn.2_Missense_Mutation_p.R1498K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1498	Ig-like 15.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCACACGGAGGCTGGTGGTG	0.672													0	0	0	0.009096	0	4	45										A	228444535	G	A	228444535	3	1	5	1	0	0	0	0	1	0	0	0	10812	1000	35	2	4547	2	OBSCN	1	228444535	Missense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	42300850	228444535	20806086	7	666										
AKT3	10000	broad.mit.edu	37	chr1	243668581	243668581	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ccacttgcagagtaggaaaaTtgagggaaatgcggccgcct	13	9	0	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr1:243668581T>C	uc001iab.1	-	13	1491	c.1410A>G	c.(1408-1410)CAA>CAG	p.Q470Q	AKT3_uc001hzz.1_Intron|AKT3_uc001iaa.2_5'Flank	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	470	AGC-kinase C-terminal.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			AGTAGGAAAATTGAGGGAAAT	0.398													0	0	0	0.069288	0	23	21										C	243668581	T	C	243668581	2	2	5	1	0	0	0	0	0	0	0	1	481	1490	52	5		5	AKT3	1	243668581	Silent	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08	15224046	243668581	5582040	8	667										
NRXN1	9378	broad.mit.edu	37	chr2	50850546	50850546	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gtgcttcaaaggcccctgatCccaaattaatgaccagagag	9	11	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr2:50850546C>T	uc010fbq.2	-	6	2616	c.1139G>A	c.(1138-1140)GGA>GAA	p.G380E	NRXN1_uc002rxb.3_Missense_Mutation_p.G27E|NRXN1_uc002rxe.3_Missense_Mutation_p.G347E|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	159	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGCCCCTGATCCCAAATTAAT	0.458													0	0	0	0.039052	0	43	94										T	50850546	C	T	50850546	3	4	5	1	0	0	0	0	1	0	0	0	10665	855	30	1	3839	1	NRXN1	2	50850546	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		50850546	192348827	9	668										
MTHFD2	10797	broad.mit.edu	37	chr2	74432845	74432845	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tctgcagaaatgaagctgttGtcatttctggaaggaaactg	11	6	3	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr2:74432845G>T	uc002skk.2	+	2	194	c.115G>T	c.(115-117)GTC>TTC	p.V39F	MTHFD2_uc002skj.2_5'UTR|MTHFD2_uc010yro.1_Intron|MTHFD2_uc010ffb.2_Missense_Mutation_p.V39F|MTHFD2_uc010yrp.1_Intron	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	39					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TGAAGCTGTTGTCATTTCTGG	0.398													1	0	0.00307968	0.038147	0.00317745	8	51										T	74432845	G	T	74432845	3	4	5	1	0	0	0	0	1	0	0	0	9929	1377	48	4	121	4	MTHFD2	2	74432845	Missense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	23582299	74432845	168766528	10	669										
SCN2A	6326	broad.mit.edu	37	chr2	166237618	166237619	+	Frame_Shift_Ins	INS	-	-	T													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ttactttggaggtcaagacaINStttttatgacagaagaacag							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr2:166237618_166237619insT	uc002udc.2	+	25	4752_4753	c.4462_4463insT	c.(4462-4464)ATTfs	p.I1488fs	SCN2A_uc002udd.2_Frame_Shift_Ins_p.I1488fs|SCN2A_uc002ude.2_Frame_Shift_Ins_p.I1488fs	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1488	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGGTCAAGACATTTTTATGACA	0.347																		2	4	---	---								T	166237619	-	T	166237618	7	5	5	1	0	1	1	0	0	0	0	0	13916	217	8	0	4652	0	SCN2A	2	166237618	Frame_Shift_Ins	INS	-	TCGA-BT-A0S7-01A-11D-A10S-08	91804773	166237618	76961755	11	670										
SCN2A	6326	broad.mit.edu	37	chr2	166245543	166245543	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	atcaccctggaagctcagttAaaggagactgtgggaaccca	11	10	2	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr2:166245543A>G	uc002udc.2	+	27	5517	c.5227A>G	c.(5227-5229)AAA>GAA	p.K1743E	SCN2A_uc002udd.2_Missense_Mutation_p.K1743E|SCN2A_uc002ude.2_Missense_Mutation_p.K1743E	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1743	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AAGCTCAGTTAAAGGAGACTG	0.458													0	0	0	0.048971	0	70	231										G	166245543	A	G	166245543	3	3	5	1	0	0	0	0	1	0	0	0	13916	363	13	5	5425	5	SCN2A	2	166245543	Missense_Mutation	SNP	A	TCGA-BT-A0S7-01A-11D-A10S-08	7925	166245543	76953830	12	671										
TTN	7273	broad.mit.edu	37	chr2	179475790	179475790	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	agtgtaatggtataaattccGgcatctgcacggacactctt	9	9	2	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr2:179475790G>A	uc010zfg.1	-	219	43586	c.43362C>T	c.(43360-43362)GCC>GCT	p.A14454A	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A8149A|TTN_uc010zfi.1_Silent_p.A8082A|TTN_uc010zfj.1_Silent_p.A7957A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15381							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATAAATTCCGGCATCTGCAC	0.393													0	0	0	0.021553	0	6	185										A	179475790	G	A	179475790	2	1	5	1	0	0	0	0	0	0	0	1	16732	1103	39	2		2	TTN	2	179475790	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	13230247	179475790	63723583	13	672										
C3orf45	132228	broad.mit.edu	37	chr3	50324241	50324241	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gggttcctgctgctgctcgcGctgctggtgctcacttgcct	13	14	1	0	rs148270141		TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr3:50324241G>A	uc003cyz.2	+	3	336	c.309G>A	c.(307-309)GCG>GCA	p.A103A		NM_153215	NP_694947	Q8N112	CC045_HUMAN	hypothetical protein LOC132228	103	Helical; (Potential).					integral to membrane				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGCTGCTCGCGCTGCTGGTGC	0.622													0	0	0	0.080935	0	11	75										A	50324241	G	A	50324241	2	1	5	1	0	0	0	0	0	0	0	1	2231	1074	38	2		2	C3orf45	3	50324241	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08		50324241	147698189	14	673										
FGFR3	2261	broad.mit.edu	37	chr4	1803564	1803564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	cgtcatctgcccccacagagCgctccccgcaccggcccatc	8	22	2	1	rs121913482		TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr4:1803564C>T	uc003gdr.3	+	7	998	c.742C>T	c.(742-744)CGC>TGC	p.R248C	FGFR3_uc003gdu.2_Missense_Mutation_p.R248C|FGFR3_uc003gds.3_Missense_Mutation_p.R248C|FGFR3_uc003gdq.3_Missense_Mutation_p.R248C|FGFR3_uc010icb.1_Missense_Mutation_p.R90C|FGFR3_uc003gdt.1_Missense_Mutation_p.R90C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	248	Extracellular (Potential).		R -> C (in KERSEB, bladder cancer, keratinocytic non-epidermolytic nevus and TD1; severe and lethal; also found as somatic mutation in one patient with multiple myeloma).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.R248C(291)|p.R248_S249insC(2)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCCCACAGAGCGCTCCCCGCA	0.567		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.080935	0	7	14										T	1803564	C	T	1803564	3	4	5	1	0	0	0	0	1	0	0	0	5867	768	27	2	764	2	FGFR3	4	1803564	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		1803564	189350712	15	674										
CWH43	80157	broad.mit.edu	37	chr4	49040081	49040081	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tcgacaggaaactgcaggctAttgctgtttcaaaactactg	9	9	1	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr4:49040081A>T	uc003gyv.2	+	13	1869	c.1687A>T	c.(1687-1689)ATT>TTT	p.I563F	CWH43_uc011bzl.1_Missense_Mutation_p.I536F	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	563					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						ACTGCAGGCTATTGCTGTTTC	0.358													0	0	0	0.048971	0	58	226										T	49040081	A	T	49040081	3	4	5	1	0	0	0	0	1	0	0	0	4073	449	16	5	1737	5	CWH43	4	49040081	Missense_Mutation	SNP	A	TCGA-BT-A0S7-01A-11D-A10S-08	47236517	49040081	142114195	16	675										
MMRN1	22915	broad.mit.edu	37	chr4	90857417	90857417	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	aaaaattttgagactcggttGcaagacattgagtctaaagt	9	5	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr4:90857417G>A	uc003hst.2	+	6	2657	c.2586G>A	c.(2584-2586)TTG>TTA	p.L862L	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.L604L	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	862	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AGACTCGGTTGCAAGACATTG	0.358													0	0	0	0.021553	0	6	26										A	90857417	G	A	90857417	2	1	5	1	0	0	0	0	0	0	0	1	9670	1310	46	2		2	MMRN1	4	90857417	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	41817336	90857417	100296859	17	676										
INPP4B	8821	broad.mit.edu	37	chr4	143159109	143159110	+	Missense_Mutation	DNP	CC	CC	TG													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	atctgctctcgaattcgcatCcacttattgtcagatgtggg							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr4:143159109_143159110CC>TG	uc003iix.3	-	13	1338_1339	c.743_744GG>CA	c.(742-744)TGG>TCA	p.W248S	INPP4B_uc003iiw.3_Missense_Mutation_p.W248S|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.W63S|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.W119S	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	248					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GAATTCGCATCCACTTATTGTC	0.327													0	0	0	0.004672	0	18	32										TG	143159110	CC	TG	143159109	3	4	5	1	0	0	0	0	1	0	0	0	7753	856	30	1	2090	1	INPP4B	4	143159109	Missense_Mutation	DNP	CC	TCGA-BT-A0S7-01A-11D-A10S-08	52301692	143159109	47995167	18	677										
FGG	2266	broad.mit.edu	37	chr4	155530879	155530879	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gtttaataaagtaaagcccgCtctgtttagctcccttattg	7	9	1	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr4:155530879C>T	uc003ioj.2	-	6	710	c.569G>A	c.(568-570)AGC>AAC	p.S190N	FGG_uc003iog.2_Missense_Mutation_p.S190N|FGG_uc003ioh.2_Missense_Mutation_p.S198N|FGG_uc010ipx.2_Missense_Mutation_p.S18N|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.S198N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	190	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GTAAAGCCCGCTCTGTTTAGC	0.418													0	0	0	0.099896	0	26	98										T	155530879	C	T	155530879	3	4	5	1	0	0	0	0	1	0	0	0	5870	797	28	2	827	2	FGG	4	155530879	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	12371770	155530879	35623397	19	678										
PARP8	79668	broad.mit.edu	37	chr5	50137809	50137809	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ttgtatttcagctatgaagaCggccaagtgggagatgcaaa	12	6	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr5:50137809C>T	uc003jon.3	+	27	2654	c.2472C>T	c.(2470-2472)GAC>GAT	p.D824D	PARP8_uc011cpz.1_Silent_p.D716D|PARP8_uc003joo.2_Silent_p.D824D|PARP8_uc003jop.2_Silent_p.D782D	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	824	PARP catalytic.					intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GCTATGAAGACGGCCAAGTGG	0.333													0	0	0	0.009096	0	4	28										T	50137809	C	T	50137809	2	4	5	1	0	0	0	0	0	0	0	1	11465	535	19	2		2	PARP8	5	50137809	Silent	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		50137809	130777451	20	679										
MRPS36	92259	broad.mit.edu	37	chr5	68524147	68524147	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tccaccagacactgcagaaaTaataaaaacattacctcaga	4	11	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr5:68524147T>C	uc003jvq.2	+	3	311	c.227T>C	c.(226-228)ATA>ACA	p.I76T	MRPS36_uc003jvr.2_RNA	NM_033281	NP_150597	P82909	RT36_HUMAN	mitochondrial ribosomal protein S36	76					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.04e-56)|Epithelial(20;8.79e-53)|all cancers(19;2.01e-48)|Lung(70;0.0176)		ACTGCAGAAATAATAAAAACA	0.388													0	0	0	0.048971	0	78	81										C	68524147	T	C	68524147	3	2	5	1	0	0	0	0	1	0	0	0	9845	1406	49	5	237	5	MRPS36	5	68524147	Missense_Mutation	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08	18386338	68524147	112391113	21	680										
PCDHAC2	56134	broad.mit.edu	37	chr5	140346900	140346900	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gtgggcgccaactcagtacaGacctacgagctcagccccag	11	15	2	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr5:140346900G>T	uc003lii.2	+	1	789	c.549G>T	c.(547-549)CAG>CAT	p.Q183H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.Q183H	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	183	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCAGTACAGACCTACGAGC	0.607													1	0	3.27435e-08	0.020292	3.73391e-08	15	14										T	140346900	G	T	140346900	3	4	5	1	0	0	0	0	1	0	0	0	11533	933	33	3	551	3	PCDHAC2	5	140346900	Missense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	71822753	140346900	40568360	22	681										
GABRB2	2561	broad.mit.edu	37	chr5	160721255	160721255	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tttcttttgcgccacatgtcGttccagagcatttcggccaa	8	12	1	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr5:160721255G>A	uc003lys.1	-	11	1590	c.1372C>T	c.(1372-1374)CGA>TGA	p.R458*	GABRB2_uc011deh.1_Nonsense_Mutation_p.R259*|GABRB2_uc003lyr.1_Nonsense_Mutation_p.R420*|GABRB2_uc003lyt.1_Nonsense_Mutation_p.R420*|GABRB2_uc010jiu.1_Nonsense_Mutation_p.R357*	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	458	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GCCACATGTCGTTCCAGAGCA	0.527													0	0	0	0.104719	0	41	61										A	160721255	G	A	160721255	4	1	5	1	0	0	0	0	0	1	0	0	6167	1153	40	2	170	2	GABRB2	5	160721255	Nonsense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	20374355	160721255	20194005	23	682										
C6orf27	80737	broad.mit.edu	37	chr6	31734406	31734406	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gctccggaggtcccacgggcTccaagggcacctggcctagt	14	15	0	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr6:31734406T>C	uc011dog.1	-	14	2256	c.2018A>G	c.(2017-2019)GAG>GGG	p.E673G	C6orf27_uc003nxd.2_Missense_Mutation_p.E348G	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	673						extracellular region				ovary(3)	3						TCCCACGGGCTCCAAGGGCAC	0.652													0	0	0	0.030593	0	29	56										C	31734406	T	C	31734406	3	2	5	1	0	0	0	0	1	0	0	0	2362	1551	54	5	672	5	C6orf27	6	31734406	Missense_Mutation	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08		31734406	139380661	24	683										
CFB	629	broad.mit.edu	37	chr6	31901504	31901504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tcttgtgctcacggggtcttCggagcgggagtgccagggca	17	10	3	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr6:31901504C>T	uc011dor.1	+	3	638	c.374C>T	c.(373-375)TCG>TTG	p.S125L	C2_uc003nyc.2_Missense_Mutation_p.R19W|C2_uc011doo.1_Missense_Mutation_p.R19W|C2_uc011dop.1_Missense_Mutation_p.S64L|C2_uc003nye.3_Missense_Mutation_p.S187L|C2_uc003nyf.2_Missense_Mutation_p.S187L|C2_uc010jtk.2_Missense_Mutation_p.S55L|C2_uc011doq.1_Missense_Mutation_p.S158L|C2_uc003nyg.2_Missense_Mutation_p.S55L	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						ACGGGGTCTTCGGAGCGGGAG	0.647													0	0	0	0.048971	0	63	74										T	31901504	C	T	31901504	3	4	5	1	0	0	0	0	1	0	0	0	3278	893	31	1		1	CFB	6	31901504	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	167098	31901504	139213563	25	684										
DOPEY1	23033	broad.mit.edu	37	chr6	83818634	83818650	+	Frame_Shift_Del	DEL	GATTATTTCCTCTTCTT	GATTATTTCCTCTTCTT	-													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ttatttttttaatagttctgGattatttcctcttcttgcaa							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr6:83818634_83818650delGATTATTTCCTCTTCTT	uc003pjs.1	+	5	586_602	c.326_342delGATTATTTCCTCTTCTT	c.(325-342)GGATTATTTCCTCTTCTTfs	p.G109fs	DOPEY1_uc011dyy.1_Frame_Shift_Del_p.G109fs|DOPEY1_uc010kbl.1_Frame_Shift_Del_p.G109fs	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	109_114					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AATAGTTCTGGATTATTTCCTCTTCTTGCAAATGCTG	0.318																		14	110	---	---								-	83818650	GATTATTTCCTCTTCTT	-	83818634	7	5	5	1	0	1	0	1	0	0	0	0	4707	1174	41	0	336	0	DOPEY1	6	83818634	Frame_Shift_Del	DEL	GATTATTTCCTCTTCTT	TCGA-BT-A0S7-01A-11D-A10S-08	51917130	83818634	87296433	26	685										
TCP10L2	401285	broad.mit.edu	37	chr6	167590551	167590552	+	Frame_Shift_Ins	INS	-	-	C													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	agagacaacgcccaaatacgINSctggccgcaagagtcagagt							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr6:167590551_167590552insC	uc010kkp.2	+	4	558_559	c.427_428insC	c.(427-429)GCTfs	p.A143fs		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	143											0						GCCCAAATACGCTGGCCGCAAG	0.465																		21	197	---	---								C	167590552	-	C	167590551	7	5	5	1	0	1	1	0	0	0	0	0	15709	1087	38	0	437	0	TCP10L2	6	167590551	Frame_Shift_Ins	INS	-	TCGA-BT-A0S7-01A-11D-A10S-08	83771917	167590551	3524516	27	686										
TCP10	6953	broad.mit.edu	37	chr6	167791512	167791513	+	Frame_Shift_Ins	INS	-	-	G													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	cactctgactcttgcggccaINSgcgtatttgggcgttgtgtc							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr6:167791512_167791513insG	uc003qvv.1	-	4	559_560	c.347_348insC	c.(346-348)GCTfs	p.A116fs	TCP10_uc003qvu.2_Frame_Shift_Ins_p.A116fs|TCP10_uc003qvw.2_Frame_Shift_Ins_p.A92fs	NM_004610	NP_004601	Q12799	TCP10_HUMAN	t-complex 10	143						cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		TCTTGCGGCCAGCGTATTTGGG	0.46																		7	122	---	---								G	167791513	-	G	167791512	7	5	5	1	0	1	1	0	0	0	0	0	15707	175	7	0	652	0	TCP10	6	167791512	Frame_Shift_Ins	INS	-	TCGA-BT-A0S7-01A-11D-A10S-08	200961	167791512	3323555	28	687										
DLX6	1750	broad.mit.edu	37	chr7	96636997	96636997	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	acggggaaatcaggttcaatGgaaaagggaaaaagattcgg	14	4	2	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr7:96636997G>A	uc003uom.2	+	3	400	c.400G>A	c.(400-402)GGA>AGA	p.G134R	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	44					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					CAGGTTCAATGGAAAAGGGAA	0.478													0	0	0	0.02938	0	6	21										A	96636997	G	A	96636997	3	1	5	1	0	0	0	0	1	0	0	0	4575	1349	47	2	490	2	DLX6	7	96636997	Missense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08		96636997	62501666	29	688										
CCDC136	64753	broad.mit.edu	37	chr7	128434455	128434457	+	In_Frame_Del	DEL	GAA	GAA	-													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	aagaggaagaggaagaggagGaagaagaggtggaagaagaa							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr7:128434455_128434457delGAA	uc003vnv.1	+	2	437_439	c.70_72delGAA	c.(70-72)GAAdel	p.E26del	CCDC136_uc003vnu.1_In_Frame_Del_p.E76del|CCDC136_uc003vnw.1_In_Frame_Del_p.E26del	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	26	Glu-rich.					integral to membrane	protein binding			ovary(2)	2						ggaagaggaggaagaagaggtgg	0.394																		2	4	---	---								-	128434457	GAA	-	128434455	7	5	5	1	0	1	0	1	0	0	0	0	2770	1175	41	0	76	0	CCDC136	7	128434455	In_Frame_Del	DEL	GAA	TCGA-BT-A0S7-01A-11D-A10S-08	31797458	128434455	30704208	30	689										
CSMD1	64478	broad.mit.edu	37	chr8	3076926	3076926	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tgttggaatcttccccttcaTagatgtgtaggaagtcatag	10	7	3	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr8:3076926T>C	uc011kwk.1	-	29	4916	c.4526A>G	c.(4525-4527)TAT>TGT	p.Y1509C	CSMD1_uc011kwj.1_Missense_Mutation_p.Y901C|CSMD1_uc003wqe.2_Missense_Mutation_p.Y665C	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1509	Extracellular (Potential).|CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCCCCTTCATAGATGTGTAG	0.443													0	0	0	0.009096	0	4	8										C	3076926	T	C	3076926	3	2	5	1	0	0	0	0	1	0	0	0	3944	1406	49	5	6339	5	CSMD1	8	3076926	Missense_Mutation	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08		3076926	143287096	31	690										
CSMD3	114788	broad.mit.edu	37	chr8	113668395	113668395	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ttacttactttcataatgaaTcttgaaaccattattggaac	4	7	2	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr8:113668395T>A	uc003ynu.2	-	18	3151	c.2992A>T	c.(2992-2994)ATT>TTT	p.I998F	CSMD3_uc003yns.2_Missense_Mutation_p.I270F|CSMD3_uc003ynt.2_Missense_Mutation_p.I958F|CSMD3_uc011lhx.1_Missense_Mutation_p.I894F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	998	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCATAATGAATCTTGAAACCA	0.308										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.020292	0	14	68										A	113668395	T	A	113668395	3	1	5	1	0	0	0	0	1	0	0	0	3946	1435	50	5	8347	5	CSMD3	8	113668395	Missense_Mutation	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08	110591469	113668395	32695627	32	691										
CSMD3	114788	broad.mit.edu	37	chr8	113678640	113678640	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gctgaaaaatggccaccacaTggggctgaaaaattaaatca	9	8	1	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr8:113678640T>A	uc003ynu.2	-	17	2841	c.2682A>T	c.(2680-2682)CCA>CCT	p.P894P	CSMD3_uc003yns.2_Silent_p.P166P|CSMD3_uc003ynt.2_Silent_p.P854P|CSMD3_uc011lhx.1_Silent_p.P790P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	894	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGCCACCACATGGGGCTGAAA	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.080935	0	10	20										A	113678640	T	A	113678640	2	1	5	1	0	0	0	0	0	0	0	1	3946	1451	51	5		5	CSMD3	8	113678640	Silent	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08	10245	113678640	32685382	33	692										
HSF1	3297	broad.mit.edu	37	chr8	145533230	145533230	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tccagcacccatgcttcctgCgtggccaggagcagctcctt	10	16	0	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr8:145533230C>T	uc003zbt.3	+	3	486	c.316C>T	c.(316-318)CGT>TGT	p.R106C	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	106	By similarity.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			ATGCTTCCTGCGTGGCCAGGA	0.612													0	0	0	0.048971	0	62	109										T	145533230	C	T	145533230	3	4	5	1	0	0	0	0	1	0	0	0	7395	768	27	2	326	2	HSF1	8	145533230	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	31854590	145533230	830792	34	693										
USP35	57558	broad.mit.edu	37	chr11	77924751	77924751	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tctgcactccccacatctccGcactgggggaggggctttga	12	14	2	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr11:77924751G>T	uc009yva.1	+	11	3195	c.2949G>T	c.(2947-2949)CCG>CCT	p.P983P	USP35_uc001ozc.2_Silent_p.P551P|USP35_uc010rsp.1_Silent_p.P415P|USP35_uc001ozd.2_Silent_p.P594P|USP35_uc001ozf.2_Silent_p.P714P	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	983					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CCACATCTCCGCACTGGGGGA	0.577													1	0	1.10923e-09	0.076483	1.2875e-09	25	126										T	77924751	G	T	77924751	2	4	5	1	0	0	0	0	0	0	0	1	17063	1074	38	4		4	USP35	11	77924751	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08		77924751	57081765	35	694										
RASSF8	11228	broad.mit.edu	37	chr12	26217667	26217667	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	cccccttagctaaactgaggCctcagattgacaaatcaatc	6	13	2	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr12:26217667C>A	uc001rgx.2	+	3	561	c.340C>A	c.(340-342)CCT>ACT	p.P114T	RASSF8_uc001rgy.2_Missense_Mutation_p.P114T|RASSF8_uc001rgz.2_Missense_Mutation_p.P114T|RASSF8_uc009zjd.1_Missense_Mutation_p.P114T|RASSF8_uc009zje.1_Missense_Mutation_p.P114T	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	114					signal transduction						0	Colorectal(261;0.0847)					TAAACTGAGGCCTCAGATTGA	0.458													1	0	3.09479e-21	0.092188	3.65748e-21	39	109										A	26217667	C	A	26217667	3	1	5	1	0	0	0	0	1	0	0	0	13092	739	26	4	346	4	RASSF8	12	26217667	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		26217667	107634228	36	695										
KRT73	319101	broad.mit.edu	37	chr12	53012081	53012081	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ccagcaaagccactggcccgGccccggccaaatccatagcc	9	19	0	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr12:53012081G>A	uc001sas.2	-	1	263	c.228C>T	c.(226-228)GGC>GGT	p.G76G		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	76	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CACTGGCCCGGCCCCGGCCAA	0.637													0	0	0	0.048971	0	73	140										A	53012081	G	A	53012081	2	1	5	1	0	0	0	0	0	0	0	1	8486	1190	42	2		2	KRT73	12	53012081	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	26794414	53012081	80839814	37	696										
FRS2	10818	broad.mit.edu	37	chr12	69968295	69968295	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ctcctgtttgggaagcccgcAagctaagtagggatgaagat	13	8	0	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr12:69968295A>C	uc001suy.2	+	10	1597	c.1087A>C	c.(1087-1089)AAG>CAG	p.K363Q	FRS2_uc001suz.2_Missense_Mutation_p.K363Q|FRS2_uc009zrj.2_Missense_Mutation_p.K363Q|FRS2_uc009zrk.2_Missense_Mutation_p.K363Q	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	363					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GGAAGCCCGCAAGCTAAGTAG	0.388													0	0	0	0.076483	0	22	901										C	69968295	A	C	69968295	3	2	5	1	0	0	0	0	1	0	0	0	6061	131	5	5	1105	5	FRS2	12	69968295	Missense_Mutation	SNP	A	TCGA-BT-A0S7-01A-11D-A10S-08	16956214	69968295	63883600	38	697										
KNTC1	9735	broad.mit.edu	37	chr12	123041992	123041992	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ggcattgagttctgtggatgCcagtgaacagaccgaatggc	14	8	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr12:123041992C>T	uc001ucv.2	+	17	1497	c.1334C>T	c.(1333-1335)GCC>GTC	p.A445V	KNTC1_uc010taf.1_Missense_Mutation_p.A408V	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	445					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TCTGTGGATGCCAGTGAACAG	0.378													0	0	0	0.004672	0	3	56										T	123041992	C	T	123041992	3	4	5	1	0	0	0	0	1	0	0	0	8428	739	26	2	1396	2	KNTC1	12	123041992	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	53073697	123041992	10809903	39	698										
AKAP6	9472	broad.mit.edu	37	chr14	32902841	32902841	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	aggcaatgaaggacatggacTctgaccagcagtatgaaaag	12	7	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr14:32902841T>A	uc001wrq.2	+	2	312	c.142T>A	c.(142-144)TCT>ACT	p.S48T	AKAP6_uc010aml.2_Missense_Mutation_p.S45T	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	48					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGACATGGACTCTGACCAGCA	0.547													0	0	0	0.041601	0	32	77										A	32902841	T	A	32902841	3	1	5	1	0	0	0	0	1	0	0	0	455	1551	54	5	144	5	AKAP6	14	32902841	Missense_Mutation	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08		32902841	74446699	40	699										
BRF1	2972	broad.mit.edu	37	chr14	105685542	105685542	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	catccacagctcggccttcaCgcgggcttccgactcattca	8	17	3	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr14:105685542C>T	uc001yqp.2	-	13	1768	c.1405G>A	c.(1405-1407)GTG>ATG	p.V469M	BRF1_uc010tyo.1_Missense_Mutation_p.V354M|BRF1_uc010typ.1_Missense_Mutation_p.V376M|BRF1_uc001yqk.2_Translation_Start_Site|BRF1_uc001yql.2_Missense_Mutation_p.V265M|BRF1_uc001yqo.2_Missense_Mutation_p.V231M|BRF1_uc010axg.1_Missense_Mutation_p.V442M|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron|BRF1_uc010axi.1_Translation_Start_Site	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	469					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		TCGGCCTTCACGCGGGCTTCC	0.642													0	0	0	0.048971	0	52	128										T	105685542	C	T	105685542	3	4	5	1	0	0	0	0	1	0	0	0	1510	536	19	2	652	2	BRF1	14	105685542	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	72782701	105685542	1663998	41	700										
USP8	9101	broad.mit.edu	37	chr15	50782647	50782647	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gaagcgctcctactcctcccCagatataacccaggctattc	6	16	0	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr15:50782647C>A	uc001zym.3	+	15	2659	c.2159C>A	c.(2158-2160)CCA>CAA	p.P720Q	USP8_uc001zyl.3_Missense_Mutation_p.P720Q|USP8_uc001zyn.3_Missense_Mutation_p.P720Q|USP8_uc010ufh.1_Missense_Mutation_p.P614Q|USP8_uc001zyp.3_5'Flank	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	720					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TACTCCTCCCCAGATATAACC	0.478													1	0	0.000274275	0.047766	0.000287547	8	170										A	50782647	C	A	50782647	3	1	5	1	0	0	0	0	1	0	0	0	17086	594	21	4	2209	4	USP8	15	50782647	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		50782647	51748745	42	701										
THSD4	79875	broad.mit.edu	37	chr15	72030241	72030241	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	cagacagattttctccccatCgaccggacaacttggtgcca	8	14	1	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr15:72030241C>T	uc002atb.1	+	10	1880	c.1801C>T	c.(1801-1803)CGA>TGA	p.R601*	THSD4_uc010ukg.1_Nonsense_Mutation_p.R241*|THSD4_uc002ate.2_Nonsense_Mutation_p.R241*	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	601						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TTCTCCCCATCGACCGGACAA	0.597													0	0	0	0.048971	0	50	52										T	72030241	C	T	72030241	4	4	5	1	0	0	0	0	0	1	0	0	15875	876	31	1	1839	1	THSD4	15	72030241	Nonsense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	21247594	72030241	30501151	43	702										
WDR90	197335	broad.mit.edu	37	chr16	703599	703599	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	agggcccctagtgtgatgcgGctctgggacttccagaccgg	15	12	1	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr16:703599G>A	uc002cii.1	+	12	1362	c.1308G>A	c.(1306-1308)CGG>CGA	p.R436R	WDR90_uc002cig.1_Silent_p.R436R|WDR90_uc002cih.1_Silent_p.R437R|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	436	WD 1.									ovary(1)	1		Hepatocellular(780;0.0218)				GTGTGATGCGGCTCTGGGACT	0.657													0	0	0	0.048971	0	50	59										A	703599	G	A	703599	2	1	5	1	0	0	0	0	0	0	0	1	17334	1190	42	2		2	WDR90	16	703599	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08		703599	89651154	44	703										
GRIN2A	2903	broad.mit.edu	37	chr16	9858022	9858022	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gggtggatctaagtggaaacCaggctccttctcaccatcta	10	11	3	0			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr16:9858022C>A	uc002czo.3	-	13	3927	c.3379G>T	c.(3379-3381)GGT>TGT	p.G1127C	GRIN2A_uc010uym.1_Missense_Mutation_p.G1127C|GRIN2A_uc010uyn.1_Missense_Mutation_p.G970C|GRIN2A_uc002czr.3_Missense_Mutation_p.G1127C	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1127	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGTGGAAACCAGGCTCCTTC	0.512													1	0	0.00829132	0.069234	0.00842087	10	260										A	9858022	C	A	9858022	3	1	5	1	0	0	0	0	1	0	0	0	6779	594	21	4	1019	4	GRIN2A	16	9858022	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	9154423	9858022	80496731	45	704										
ABCC6	368	broad.mit.edu	37	chr16	16297362	16297362	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tggaacacctgccagatggcCttcagcagtgggcgccactg	13	13	1	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr16:16297362C>T	uc002den.3	-	8	940	c.903G>A	c.(901-903)AAG>AAA	p.K301K	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.K313K	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	301	Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GCCAGATGGCCTTCAGCAGTG	0.567													0	0	0	0.037714	0	23	53										T	16297362	C	T	16297362	2	4	5	1	0	0	0	0	0	0	0	1	57	680	24	2		2	ABCC6	16	16297362	Silent	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08	6439340	16297362	74057391	46	705										
CCDC144A	9720	broad.mit.edu	37	chr17	16593762	16593762	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ggaggggctgaggggtctccGaagccggcagtctacgccac	17	12	2	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr17:16593762G>A	uc002gqk.1	+	1	124	c.48G>A	c.(46-48)CCG>CCA	p.P16P		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	16											0						AGGGGTCTCCGAAGCCGGCAG	0.672													0	0	0	0.02938	0	7	42										A	16593762	G	A	16593762	2	1	5	1	0	0	0	0	0	0	0	1	2777	1045	37	1		1	CCDC144A	17	16593762	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08		16593762	64601448	47	706										
MRM1	79922	broad.mit.edu	37	chr17	34958251	34958281	+	Frame_Shift_Del	DEL	CTCGACCGTCCGGGGCGCGACCTGGGGTCGC	CTCGACCGTCCGGGGCGCGACCTGGGGTCGC	-													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	agctgcgccatggcattgctCtcgaccgtccggggcgcgac					rs141604685		TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr17:34958251_34958281delCTCGACCGTCCGGGGCGCGACCTGGGGTCGC	uc002hne.2	+	1	227_257	c.12_42delCTCGACCGTCCGGGGCGCGACCTGGGGTCGC	c.(10-42)CTCTCGACCGTCCGGGGCGCGACCTGGGGTCGCfs	p.L4fs	MRM1_uc002hnf.2_5'Flank	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	4_14					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGGCATTGCTCTCGACCGTCCGGGGCGCGACCTGGGGTCGCCTCGTCACCC	0.697																		14	97	---	---								-	34958281	CTCGACCGTCCGGGGCGCGACCTGGGGTCGC	-	34958251	7	5	5	1	0	1	0	1	0	0	0	0	9771	900	32	0	14	0	MRM1	17	34958251	Frame_Shift_Del	DEL	CTCGACCGTCCGGGGCGCGACCTGGGGTCGC	TCGA-BT-A0S7-01A-11D-A10S-08	18364489	34958251	46236959	48	707										
SDK2	54549	broad.mit.edu	37	chr17	71433929	71433929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ctccatctccgcagtgatgtGtctttctggctccttgacaa	8	13	3	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr17:71433929G>A	uc010dfm.2	-	8	949	c.949C>T	c.(949-951)CAC>TAC	p.H317Y	SDK2_uc010dfn.2_5'UTR	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	317	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion	integral to membrane				ovary(2)	2						GCAGTGATGTGTCTTTCTGGC	0.587													0	0	0	0.048971	0	53	92										A	71433929	G	A	71433929	3	1	5	1	0	0	0	0	1	0	0	0	13969	1377	48	2	5721	2	SDK2	17	71433929	Missense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	36475678	71433929	9761281	49	708										
MUC16	94025	broad.mit.edu	37	chr19	9045585	9045585	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tgttcttgaggtcacactctCagaggccaaggtggacatcc	11	11	3	2			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr19:9045585C>T	uc002mkp.2	-	5	36250	c.36046G>A	c.(36046-36048)GAG>AAG	p.E12016K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12018	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCACACTCTCAGAGGCCAAG	0.333													0	0	0	0.038395	0	18	15										T	9045585	C	T	9045585	3	4	5	1	0	0	0	0	1	0	0	0	9973	835	29	1	7797	1	MUC16	19	9045585	Missense_Mutation	SNP	C	TCGA-BT-A0S7-01A-11D-A10S-08		9045585	50083398	50	709										
C19orf44	84167	broad.mit.edu	37	chr19	16612266	16612266	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gaagaagaaatgaaagtattGctaggaagcttgatggactc	12	4	0	4			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr19:16612266G>T	uc002neh.1	+	2	736	c.663G>T	c.(661-663)TTG>TTT	p.L221F	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.L221F|C19orf44_uc002neg.2_Missense_Mutation_p.L221F|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	221											0						TGAAAGTATTGCTAGGAAGCT	0.433													1	0	8.10497e-08	0.055883	9.08316e-08	21	83										T	16612266	G	T	16612266	3	4	5	1	0	0	0	0	1	0	0	0	1927	1310	46	4	665	4	C19orf44	19	16612266	Missense_Mutation	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	7566681	16612266	42516717	51	710										
NLRP12	91662	broad.mit.edu	37	chr19	54327327	54327327	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	ccttctcccagctctgtcgcGgtccccaggtataacttgaa	8	15	2	1			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr19:54327327G>A	uc002qch.3	-	1	322	c.102C>T	c.(100-102)ACC>ACT	p.T34T	NLRP12_uc002qci.3_Silent_p.T34T|NLRP12_uc002qcj.3_Silent_p.T34T|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.T34T	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	34	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GCTCTGTCGCGGTCCCCAGGT	0.602													0	0	0	0.048971	0	51	98										A	54327327	G	A	54327327	2	1	5	1	0	0	0	0	0	0	0	1	10474	1103	39	2		2	NLRP12	19	54327327	Silent	SNP	G	TCGA-BT-A0S7-01A-11D-A10S-08	37715061	54327327	4801656	52	711										
PTPRT	11122	broad.mit.edu	37	chr20	40735463	40735463	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	tgaccctttgggcccggagcTcacgcacgcagttgaagatg	13	12	1	3			TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chr20:40735463T>G	uc002xkg.2	-	24	3537	c.3353A>C	c.(3352-3354)GAG>GCG	p.E1118A	PTPRT_uc010ggj.2_Missense_Mutation_p.E1137A|PTPRT_uc010ggi.2_Missense_Mutation_p.E321A	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1118	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGCCCGGAGCTCACGCACGCA	0.577													0	0	0	0.048971	0	76	191										G	40735463	T	G	40735463	3	3	5	1	0	0	0	0	1	0	0	0	12812	1551	54	5	1004	5	PTPRT	20	40735463	Missense_Mutation	SNP	T	TCGA-BT-A0S7-01A-11D-A10S-08		40735463	22290057	53	712										
KDM6A	7403	broad.mit.edu	37	chrX	44896934	44896934	+	Frame_Shift_Del	DEL	G	G	-													0.0185185185185185	1	0.964840597705622	0.318475452196382	0	0.33232221098753	1	1	0	gcccacttatatgaaacccaGgtaagtattttaacttattc							TCGA-BT-A0S7-01A-11D-A10S-08	TCGA-BT-A0S7-10A-01D-A10S-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b2e5d244-94c1-4dbf-8d33-34b595903310	5f37608e-793b-4409-ba17-aaebe59f214d	g.chrX:44896934delG	uc004dge.3	+	8	1029	c.654delG	c.(652-654)CAGfs	p.Q218fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.Q218fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.Q218fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.Q218fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.Q218fs|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	218	TPR 4.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						ATGAAACCCAGGTAAGTATTT	0.303			D|N|F|S		renal|oesophageal SCC|MM													23	24	---	---								-	44896934	G	-	44896934	7	5	5	1	0	1	0	1	0	0	0	0	8137	1014	35	0	684	0	KDM6A	23	44896934	Frame_Shift_Del	DEL	G	TCGA-BT-A0S7-01A-11D-A10S-08		44896934	110373626	54	713										
PLEKHN1	84069	broad.mit.edu	37	chr1	909923	909923	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcccccagcttggagggcctGaggccagtggggggcttgtg	19	11	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:909923G>C	uc001ace.2	+	15	1995	c.1960G>C	c.(1960-1962)GAG>CAG	p.E654Q	PLEKHN1_uc001acd.2_Missense_Mutation_p.E602Q|PLEKHN1_uc001acf.2_Missense_Mutation_p.E567Q	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	654											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGGAGGGCCTGAGGCCAGTGG	0.662													0	0	0	0.004482	0	9	20										C	909923	G	C	909923	3	2	6	1	0	0	0	0	1	0	0	0	12083	1291	45	1	1902	1	PLEKHN1	1	909923	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		909923	248340698	1	714										
NOL9	79707	broad.mit.edu	37	chr1	6592664	6592664	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgagtctgaaacgtcgatttCtcatcttggtcttgcttttt	8	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:6592664C>T	uc001ans.2	-	8	1413	c.1394G>A	c.(1393-1395)AGA>AAA	p.R465K	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	465					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		ACGTCGATTTCTCATCTTGGT	0.433													0	0	0	0.01441	0	46	147										T	6592664	C	T	6592664	3	4	6	1	0	0	0	0	1	0	0	0	10528	913	32	1	734	1	NOL9	1	6592664	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5682741	6592664	242657957	2	715										
RERE	473	broad.mit.edu	37	chr1	8418325	8418325	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agagtgctggtgatggtgcgGagtcacgttgaacatctgca	15	7	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:8418325G>C	uc001ape.2	-	21	5080	c.4270C>G	c.(4270-4272)CCG>GCG	p.P1424A	RERE_uc001apf.2_Missense_Mutation_p.P1424A|RERE_uc001apd.2_Missense_Mutation_p.P870A	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1424					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		tgatggtgCGGAGTCACGTTG	0.438													0	0	0	0.006214	0	10	34										C	8418325	G	C	8418325	3	2	6	1	0	0	0	0	1	0	0	0	13231	1174	41	1	446	1	RERE	1	8418325	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1825661	8418325	240832296	3	716										
CLSTN1	22883	broad.mit.edu	37	chr1	9801223	9801223	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgggtaatcctcagtcacaGagaagggctcgtgggacgtg	16	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:9801223G>A	uc001aqh.2	-	10	2207	c.1448C>T	c.(1447-1449)TCT>TTT	p.S483F	CLSTN1_uc001aqi.2_Missense_Mutation_p.S473F|CLSTN1_uc010oag.1_Missense_Mutation_p.S483F	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	483	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CTCAGTCACAGAGAAGGGCTC	0.552													0	0	0	0.010504	0	19	79										A	9801223	G	A	9801223	3	1	6	1	0	0	0	0	1	0	0	0	3561	942	33	1	1537	1	CLSTN1	1	9801223	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1382898	9801223	239449398	4	717										
CASZ1	54897	broad.mit.edu	37	chr1	10725233	10725233	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accgccgtccttggagggctCctccgcgtggtcttcctcat	11	16	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:10725233C>G	uc001aro.2	-	5	732	c.412G>C	c.(412-414)GAG>CAG	p.E138Q	CASZ1_uc001arp.1_Missense_Mutation_p.E138Q|CASZ1_uc009vmx.2_Missense_Mutation_p.E162Q	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TTGGAGGGCTCCTCCGCGTGG	0.692													0	0	0	0.001855	0	11	57										G	10725233	C	G	10725233	3	3	6	1	0	0	0	0	1	0	0	0	2685	864	30	1	4939	1	CASZ1	1	10725233	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	924010	10725233	238525388	5	718										
MTOR	2475	broad.mit.edu	37	chr1	11184592	11184592	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agatgttgggtcattggccaGaagggtgttaaccaggccga	15	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:11184592G>C	uc001asd.2	-	47	6746	c.6625C>G	c.(6625-6627)CTG>GTG	p.L2209V	MTOR_uc001asc.2_Missense_Mutation_p.L414V	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2209	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TCATTGGCCAGAAGGGTGTTA	0.463													0	0	0	0.00245	0	15	72										C	11184592	G	C	11184592	3	2	6	1	0	0	0	0	1	0	0	0	9954	933	33	1	1072	1	MTOR	1	11184592	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	459359	11184592	238066029	6	719										
VPS13D	55187	broad.mit.edu	37	chr1	12333105	12333105	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggctggatatttctgcccctCaggtgatatttcctgatgat	10	9	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:12333105C>T	uc001atv.2	+	18	2290	c.2149C>T	c.(2149-2151)CAG>TAG	p.Q717*	VPS13D_uc001atw.2_Nonsense_Mutation_p.Q717*|VPS13D_uc001atx.2_5'Flank	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	717					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTCTGCCCCTCAGGTGATATT	0.428													0	0	0	0.007291	0	27	101										T	12333105	C	T	12333105	4	4	6	1	0	0	0	0	0	1	0	0	17189	827	29	1	2215	1	VPS13D	1	12333105	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1148513	12333105	236917516	7	720										
VPS13D	55187	broad.mit.edu	37	chr1	12333134	12333134	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttcctgatgatttcaaattCaagaatcctgtgttagttgt	7	6	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:12333134C>G	uc001atv.2	+	18	2319	c.2178C>G	c.(2176-2178)TTC>TTG	p.F726L	VPS13D_uc001atw.2_Missense_Mutation_p.F726L|VPS13D_uc001atx.2_5'Flank	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	726					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ATTTCAAATTCAAGAATCCTG	0.423													0	0	0	0.008871	0	19	88										G	12333134	C	G	12333134	3	3	6	1	0	0	0	0	1	0	0	0	17189	825	29	1	2244	1	VPS13D	1	12333134	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	29	12333134	236917487	8	721										
PADI2	11240	broad.mit.edu	37	chr1	17395563	17395563	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcaccatgtgccaccacttGaaggtgaagggcttcctgcg	13	12	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:17395563G>A	uc001baf.2	-	16	2056	c.1974C>T	c.(1972-1974)TTC>TTT	p.F658F	PADI2_uc010ocm.1_Silent_p.F542F	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	658					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	GCCACCACTTGAAGGTGAAGG	0.592													0	0	0	0.003755	0	33	117										A	17395563	G	A	17395563	2	1	6	1	0	0	0	0	0	0	0	1	11378	1281	45	1		1	PADI2	1	17395563	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5062429	17395563	231855058	9	722										
PADI2	11240	broad.mit.edu	37	chr1	17395644	17395644	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taggcagaaatgtcgtcgatGaaggtgcattcgaggcccag	14	8	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:17395644G>A	uc001baf.2	-	16	1975	c.1893C>T	c.(1891-1893)TTC>TTT	p.F631F	PADI2_uc010ocm.1_Silent_p.F515F	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	631					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TGTCGTCGATGAAGGTGCATT	0.597													0	0	0	0.00623	0	38	142										A	17395644	G	A	17395644	2	1	6	1	0	0	0	0	0	0	0	1	11378	1281	45	1		1	PADI2	1	17395644	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	81	17395644	231854977	10	723										
PADI3	51702	broad.mit.edu	37	chr1	17575710	17575710	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtggctggcgtggagaccctCgtggacatttatgggtaaga	16	7	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:17575710C>A	uc001bai.2	+	1	118	c.78C>A	c.(76-78)CTC>CTA	p.L26L		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	26					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGGAGACCCTCGTGGACATTT	0.602													1	0	6.94344e-10	0.006122	7.10421e-10	17	105										A	17575710	C	A	17575710	2	1	6	1	0	0	0	0	0	0	0	1	11379	871	31	3		3	PADI3	1	17575710	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	180066	17575710	231674911	11	724										
ALPL	249	broad.mit.edu	37	chr1	21889741	21889741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcaacaccacccaggggaacGaggtcacctccatcctgcgc	10	17	1	0	rs138587317		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:21889741G>A	uc001bet.2	+	5	693	c.436G>A	c.(436-438)GAG>AAG	p.E146K	ALPL_uc010odn.1_Missense_Mutation_p.E94K|ALPL_uc010odo.1_Missense_Mutation_p.E91K|ALPL_uc010odp.1_Missense_Mutation_p.E69K|ALPL_uc001beu.3_Missense_Mutation_p.E146K	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	146					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	CCAGGGGAACGAGGTCACCTC	0.547													0	0	0	0.004007	0	17	61										A	21889741	G	A	21889741	3	1	6	1	0	0	0	0	1	0	0	0	547	1059	37	1	450	1	ALPL	1	21889741	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4314031	21889741	227360880	12	725										
PAFAH2	5051	broad.mit.edu	37	chr1	26288494	26288494	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgtgcctacaggctggacaGatggtggggggcccctgggg	19	9	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:26288494G>C	uc001bld.3	-	11	1345	c.1165C>G	c.(1165-1167)CTG>GTG	p.L389V	PAFAH2_uc001ble.3_Missense_Mutation_p.L389V	NM_000437	NP_000428	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2	389					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			ovary(2)	2		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCTGGACAGATGGTGGGGG	0.488													0	0	0	0.01441	0	83	252										C	26288494	G	C	26288494	3	2	6	1	0	0	0	0	1	0	0	0	11387	933	33	1	17	1	PAFAH2	1	26288494	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4398753	26288494	222962127	13	726										
ARID1A	8289	broad.mit.edu	37	chr1	27106166	27106166	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagcaccttgaccgaggatgGagctaagagttcagaggcca	13	9	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:27106166G>C	uc001bmv.1	+	20	6150	c.5777G>C	c.(5776-5778)GGA>GCA	p.G1926A	ARID1A_uc001bmu.1_Missense_Mutation_p.G1709A|ARID1A_uc001bmx.1_Missense_Mutation_p.G772A|ARID1A_uc009vsm.1_Missense_Mutation_p.G254A|ARID1A_uc009vsn.1_Missense_Mutation_p.G168A	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1926					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACCGAGGATGGAGCTAAGAGT	0.542			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	47	143										C	27106166	G	C	27106166	3	2	6	1	0	0	0	0	1	0	0	0	913	1174	41	1	5855	1	ARID1A	1	27106166	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	817672	27106166	222144455	14	727										
YTHDF2	51441	broad.mit.edu	37	chr1	29070328	29070328	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aactgcgacacattcgcctaGagaacaacgagaataaacca	7	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:29070328G>C	uc001brc.2	+	4	2043	c.1546G>C	c.(1546-1548)GAG>CAG	p.E516Q	YTHDF2_uc001brd.2_Missense_Mutation_p.E513Q|YTHDF2_uc010ofx.1_Missense_Mutation_p.E466Q|YTHDF2_uc001bre.2_Missense_Mutation_p.E466Q	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	516	YTH.				humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CATTCGCCTAGAGAACAACGA	0.478													0	0	0	0.007291	0	30	58										C	29070328	G	C	29070328	3	2	6	1	0	0	0	0	1	0	0	0	17496	943	33	1	1560	1	YTHDF2	1	29070328	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1964162	29070328	220180293	15	728										
PTPRU	10076	broad.mit.edu	37	chr1	29609213	29609213	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accaggtgattgtggaggagGagcgggcgcggaggctgcgg	22	7	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:29609213G>A	uc001bru.2	+	12	2004	c.1894G>A	c.(1894-1896)GAG>AAG	p.E632K	PTPRU_uc001brv.2_Missense_Mutation_p.E632K|PTPRU_uc001brw.2_Missense_Mutation_p.E632K|PTPRU_uc009vtq.2_Missense_Mutation_p.E632K|PTPRU_uc009vtr.2_Missense_Mutation_p.E632K	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	632	Extracellular (Potential).|Fibronectin type-III 4.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		TGTGGAGGAGGAGCGGGCGCG	0.582													0	0	0	0.008871	0	16	47										A	29609213	G	A	29609213	3	1	6	1	0	0	0	0	1	0	0	0	12813	1175	41	1	1940	1	PTPRU	1	29609213	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	538885	29609213	219641408	16	729										
YARS	8565	broad.mit.edu	37	chr1	33245110	33245110	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtccagaggttcaacctggCggtttatcccttctctggga	12	11	2	1	rs147005844	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:33245110C>T	uc001bvy.1	-	12	2137	c.1349G>A	c.(1348-1350)CGC>CAC	p.R450H	YARS_uc001bvw.1_Missense_Mutation_p.R110H|YARS_uc001bvx.1_Missense_Mutation_p.R101H	NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	450	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TTCAACCTGGCGGTTTATCCC	0.557													0	0	0	0.013726	0	34	83										T	33245110	C	T	33245110	3	4	6	1	0	0	0	0	1	0	0	0	17464	768	27	2	245	2	YARS	1	33245110	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3635897	33245110	216005511	17	730										
SFPQ	6421	broad.mit.edu	37	chr1	35654606	35654606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccttaaacacaattttacctCaattgcatttctttacgttt	2	10	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:35654606C>G	uc001bys.2	-	6	1788	c.1695G>C	c.(1693-1695)TTG>TTC	p.L565F	SFPQ_uc001byr.2_RNA	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	565					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				AATTTTACCTCAATTGCATTT	0.229			T	TFE3	papillary renal cell								0	0	0	0.004672	0	3	46										G	35654606	C	G	35654606	3	3	6	1	0	0	0	0	1	0	0	0	14160	825	29	1	448	1	SFPQ	1	35654606	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2409496	35654606	213596015	18	731										
MACF1	23499	broad.mit.edu	37	chr1	39797236	39797236	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaagctcacctggcaactgGaggtttcagtctttccccta	9	12	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:39797236G>C	uc010oiu.1	+	1	427	c.296G>C	c.(295-297)GGA>GCA	p.G99A	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1664	Plectin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGGCAACTGGAGGTTTCAGT	0.433													0	0	0	0.010818	0	29	114										C	39797236	G	C	39797236	3	2	6	1	0	0	0	0	1	0	0	0	9144	1174	41	1	5067	1	MACF1	1	39797236	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4142630	39797236	209453385	19	732										
KIAA0467	23334	broad.mit.edu	37	chr1	43893963	43893963	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgacctcccaggatttgctGacagcggtagatgcctgtga	13	10	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:43893963G>A	uc001cjk.1	+	13	1737	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1324						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGGATTTGCTGACAGCGGTAG	0.547													0	0	0	0.00278	0	23	74										A	43893963	G	A	43893963	2	1	6	1	0	0	0	0	0	0	0	1	8178	1277	45	1		1	KIAA0467	1	43893963	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4096727	43893963	205356658	20	733										
KIAA0467	23334	broad.mit.edu	37	chr1	43905293	43905293	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caggggttgcctgcatcactCtagcctttgtggatgaagga	13	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:43905293C>G	uc001cjk.1	+	35	4660	c.4198C>G	c.(4198-4200)CTA>GTA	p.L1400V		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2299						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGCATCACTCTAGCCTTTGT	0.622													0	0	0	0.00874	0	40	170										G	43905293	C	G	43905293	3	3	6	1	0	0	0	0	1	0	0	0	8178	912	32	1	4328	1	KIAA0467	1	43905293	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	11330	43905293	205345328	21	734										
CYP4A22	284541	broad.mit.edu	37	chr1	47614449	47614449	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggaggctccctaacccttgtGaagacaaggaccagctttga	11	11	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:47614449G>A	uc001cqv.1	+	12	1591	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K		NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	514						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						TAACCCTTGTGAAGACAAGGA	0.463													0	0	0	0.000602	0	5	87										A	47614449	G	A	47614449	3	1	6	1	0	0	0	0	1	0	0	0	4184	1291	45	1	1586	1	CYP4A22	1	47614449	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3709156	47614449	201636172	22	735										
CYB5RL	606495	broad.mit.edu	37	chr1	54644891	54644891	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggaggaaggttttcaggtaGatgctctcaaaggtcttgaa	13	5	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:54644891G>C	uc009vzo.2	-	7	995	c.675C>G	c.(673-675)ATC>ATG	p.I225M	CYB5RL_uc001cww.2_Missense_Mutation_p.I115M|CYB5RL_uc001cwx.3_RNA|CYB5RL_uc001cwy.3_Missense_Mutation_p.I77M	NM_001031672	NP_001026842	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	225							cytochrome-b5 reductase activity				0						TTTTCAGGTAGATGCTCTCAA	0.512													0	0	0	0.001984	0	7	12										C	54644891	G	C	54644891	3	2	6	1	0	0	0	0	1	0	0	0	4130	932	33	1	280	1	CYB5RL	1	54644891	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7030442	54644891	194605730	23	736										
C1orf175	374977	broad.mit.edu	37	chr1	55136238	55136238	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagcaggccatggagatcctGacccagctgaggtgtccatg	13	11	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:55136238G>C	uc010ooe.1	+	6	1782	c.1458G>C	c.(1456-1458)CTG>CTC	p.L486L	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Silent_p.L54L|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.L4L|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Silent_p.L486L|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_Intron|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	486						integral to membrane	binding				0						TGGAGATCCTGACCCAGCTGA	0.378													0	0	0	0.008291	0	9	30										C	55136238	G	C	55136238	2	2	6	1	0	0	0	0	0	0	0	1	2016	1277	45	1		1	C1orf175	1	55136238	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	491347	55136238	194114383	24	737										
HOOK1	51361	broad.mit.edu	37	chr1	60336747	60336747	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagcaaaattccgtgattatGaagaaaaactcattgtttct	6	6	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:60336747G>T	uc009wad.2	+	22	2083	c.1981G>T	c.(1981-1983)GAA>TAA	p.E661*	HOOK1_uc001czo.2_Nonsense_Mutation_p.E661*|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Nonsense_Mutation_p.E619*	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	661	Sufficient for interaction with AKTIP and VPS18.			EE->AA: Abrogates interaction with AKTIP, VPS16, VPS18, VPS39 and VPS41, but does not affect interaction with HOOK2 or HOOK3; when associated with 669-A-A-670.	early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					CCGTGATTATGAAGAAAAACT	0.328													1	0	3.5997e-14	0.014323	3.71169e-14	19	45										T	60336747	G	T	60336747	4	4	6	1	0	0	0	0	0	1	0	0	7282	1291	45	3	2063	3	HOOK1	1	60336747	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5200509	60336747	188913874	25	738										
JAK1	3716	broad.mit.edu	37	chr1	65304176	65304176	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctgaacggcatattttagcTgctgtttgaggtttattttg	10	5	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:65304176T>A	uc001dbu.1	-	21	3188	c.2939A>T	c.(2938-2940)CAG>CTG	p.Q980L	JAK1_uc009wam.1_Missense_Mutation_p.Q968L|JAK1_uc009wal.1_Missense_Mutation_p.Q157L	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	980	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.E966_K989del(1)		haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		ATATTTTAGCTGCTGTTTGAG	0.358			Mis		ALL								0	0	0	0.003954	0	23	92										A	65304176	T	A	65304176	3	1	6	1	0	0	0	0	1	0	0	0	7937	1580	55	5	545	5	JAK1	1	65304176	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	4967429	65304176	183946445	26	739										
SLC44A5	204962	broad.mit.edu	37	chr1	75699699	75699699	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ataattccaatcacaccaatCatgaagacccagaagaggca	6	11	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:75699699C>T	uc001dgu.2	-	12	969	c.825G>A	c.(823-825)ATG>ATA	p.M275I	SLC44A5_uc001dgt.2_Missense_Mutation_p.M275I|SLC44A5_uc001dgs.2_Missense_Mutation_p.M233I|SLC44A5_uc001dgr.2_Missense_Mutation_p.M233I|SLC44A5_uc010oqz.1_Missense_Mutation_p.M314I|SLC44A5_uc010ora.1_Missense_Mutation_p.M269I|SLC44A5_uc010orb.1_Missense_Mutation_p.M145I	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	275	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TCACACCAATCATGAAGACCC	0.373													0	0	0	0.00874	0	38	134										T	75699699	C	T	75699699	3	4	6	1	0	0	0	0	1	0	0	0	14639	826	29	1	1497	1	SLC44A5	1	75699699	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	10395523	75699699	173550922	27	740										
USP33	23032	broad.mit.edu	37	chr1	78163603	78163603	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcaatcttagtattgtcaatAggacctggaggatctaaagg	11	6	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:78163603A>G	uc001dht.2	-	24	2963	c.2616T>C	c.(2614-2616)CCT>CCC	p.P872P	USP33_uc009wca.1_RNA|USP33_uc001dhs.2_Missense_Mutation_p.L559P|USP33_uc001dhu.2_Silent_p.P841P	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	872	DUSP 2.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						TATTGTCAATAGGACCTGGAG	0.313													0	0	0	0.01441	0	51	142										G	78163603	A	G	78163603	2	3	6	1	0	0	0	0	0	0	0	1	17061	407	15	5		5	USP33	1	78163603	Silent	SNP	A	TCGA-BT-A0YX-01A-11D-A10S-08	2463904	78163603	171087018	28	741										
LPHN2	23266	broad.mit.edu	37	chr1	82456494	82456494	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagtgaagtccgagggaactGacagctatgtctcccaactg	11	10	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:82456494G>C	uc001dit.3	+	21	4058	c.3877G>C	c.(3877-3879)GAC>CAC	p.D1293H	LPHN2_uc001dis.2_Missense_Mutation_p.D273H|LPHN2_uc001diu.2_Missense_Mutation_p.D1293H|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.D920H	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1349	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CGAGGGAACTGACAGCTATGT	0.512													0	0	0	0.004656	0	28	100										C	82456494	G	C	82456494	3	2	6	1	0	0	0	0	1	0	0	0	8916	1290	45	1	3951	1	LPHN2	1	82456494	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4292891	82456494	166794127	29	742										
COL24A1	255631	broad.mit.edu	37	chr1	86554904	86554904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cattaatccagaaaggccttGatcaccctataaacaaaata	4	10	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:86554904G>C	uc001dlj.2	-	7	1702	c.1660C>G	c.(1660-1662)CAA>GAA	p.Q554E	COL24A1_uc010osd.1_Translation_Start_Site|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.Q554E	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	554	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GAAAGGCCTTGATCACCCTAT	0.294													0	0	0	0.00632	0	24	72										C	86554904	G	C	86554904	3	2	6	1	0	0	0	0	1	0	0	0	3683	1299	45	1	3700	1	COL24A1	1	86554904	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4098410	86554904	162695717	30	743										
CCBL2	56267	broad.mit.edu	37	chr1	89426873	89426873	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttttaagtgcttatttccaGaatatacaagccattcataa	4	7	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:89426873G>C	uc001dmp.2	-	8	1141	c.764C>G	c.(763-765)TCT>TGT	p.S255C	CCBL2_uc001dmq.2_Missense_Mutation_p.S221C|CCBL2_uc001dmr.2_Missense_Mutation_p.S91C	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	255					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTTATTTCCAGAATATACAAG	0.383													0	0	0	0.008361	0	28	110										C	89426873	G	C	89426873	3	2	6	1	0	0	0	0	1	0	0	0	2733	942	33	1	628	1	CCBL2	1	89426873	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2871969	89426873	159823748	31	744										
LRRC8B	23507	broad.mit.edu	37	chr1	90049431	90049431	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaataatgaatggacagttGagaaactgaaaagtaagctt	9	4	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:90049431G>C	uc001dni.2	+	7	1729	c.1222G>C	c.(1222-1224)GAG>CAG	p.E408Q	LRRC8B_uc001dnh.2_Missense_Mutation_p.E408Q|LRRC8B_uc001dnj.2_Missense_Mutation_p.E408Q	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	408						integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		ATGGACAGTTGAGAAACTGAA	0.383													0	0	0	0.012319	0	22	89										C	90049431	G	C	90049431	3	2	6	1	0	0	0	0	1	0	0	0	9022	1291	45	1	1224	1	LRRC8B	1	90049431	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	622558	90049431	159201190	32	745										
TGFBR3	7049	broad.mit.edu	37	chr1	92193314	92193314	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagatttttgaccacttcaaGatcctcttgagaaggtctta	8	8	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:92193314G>C	uc001doh.2	-	7	1253	c.787C>G	c.(787-789)CTT>GTT	p.L263V	TGFBR3_uc009wde.2_Missense_Mutation_p.L41V|TGFBR3_uc010osy.1_Missense_Mutation_p.L221V|TGFBR3_uc001doi.2_Missense_Mutation_p.L263V|TGFBR3_uc001doj.2_Missense_Mutation_p.L263V	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	263	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		ACCACTTCAAGATCCTCTTGA	0.383													0	0	0	0.007413	0	18	74										C	92193314	G	C	92193314	3	2	6	1	0	0	0	0	1	0	0	0	15820	942	33	1	1812	1	TGFBR3	1	92193314	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2143883	92193314	157057307	33	746										
CCDC18	343099	broad.mit.edu	37	chr1	93649605	93649605	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaaagctaattttggatgttCagcctagccaccctggactt	8	10	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:93649605C>T	uc001dpq.2	+	3	727	c.559C>T	c.(559-561)CAG>TAG	p.Q187*		NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	69										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TTTGGATGTTCAGCCTAGCCA	0.353													0	0	0	0.011902	0	43	134										T	93649605	C	T	93649605	4	4	6	1	0	0	0	0	0	1	0	0	2794	827	29	1	569	1	CCDC18	1	93649605	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1456291	93649605	155601016	34	747										
FAM102B	284611	broad.mit.edu	37	chr1	109103109	109103109	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgagctcgaggagctctcctCagtgcccttcgtcaatgggg	13	13	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:109103109C>T	uc010ouy.1	+	1	139	c.59C>T	c.(58-60)TCA>TTA	p.S20L		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	20										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GAGCTCTCCTCAGTGCCCTTC	0.627													0	0	0	0.006122	0	18	62										T	109103109	C	T	109103109	3	4	6	1	0	0	0	0	1	0	0	0	5383	838	29	1	61	1	FAM102B	1	109103109	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	15453504	109103109	140147512	35	748										
RBM15	64783	broad.mit.edu	37	chr1	110882500	110882500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acgttcctctggggccgcctCctcagctcccggcggcgggg	15	17	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:110882500C>T	uc001dzl.1	+	1	556	c.473C>T	c.(472-474)TCC>TTC	p.S158F	RBM15_uc001dzm.1_Missense_Mutation_p.S158F|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	158	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGGGCCGCCTCCTCAGCTCCC	0.642			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	11	53										T	110882500	C	T	110882500	3	4	6	1	0	0	0	0	1	0	0	0	13116	855	30	1	475	1	RBM15	1	110882500	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1779391	110882500	138368121	36	749										
CHIA	27159	broad.mit.edu	37	chr1	111854982	111854982	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcgaatggaatgatgtgactCtctaccaagctttcaatggc	9	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:111854982C>G	uc001eas.2	+	4	329	c.226C>G	c.(226-228)CTC>GTC	p.L76V	CHIA_uc001ear.2_Intron|CHIA_uc001eaq.2_Intron|CHIA_uc009wgc.2_Intron|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_Intron|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	76					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		TGATGTGACTCTCTACCAAGC	0.443													0	0	0	0.010771	0	42	116										G	111854982	C	G	111854982	3	3	6	1	0	0	0	0	1	0	0	0	3342	913	32	1	236	1	CHIA	1	111854982	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	972482	111854982	137395639	37	750										
SLC16A1	6566	broad.mit.edu	37	chr1	113460506	113460506	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaattagaaagcttcctctCcatccaaagataccgaagaa	6	10	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:113460506C>T	uc001ecx.2	-	4	1354	c.522G>A	c.(520-522)TGG>TGA	p.W174*	SLC16A1_uc001ecy.2_Nonsense_Mutation_p.W174*|SLC16A1_uc001ecz.2_Nonsense_Mutation_p.W174*	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	174	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	AGCTTCCTCTCCATCCAAAGA	0.557													0	0	0	0.008871	0	21	73										T	113460506	C	T	113460506	4	4	6	1	0	0	0	0	0	1	0	0	14402	856	30	1	988	1	SLC16A1	1	113460506	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1605524	113460506	135790115	38	751										
NOTCH2	4853	broad.mit.edu	37	chr1	120529700	120529700	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctctcacaggtgctcccttCaaaacctggtaaatgaagaa	7	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:120529700C>G	uc001eik.2	-	5	1013	c.757G>C	c.(757-759)GAA>CAA	p.E253Q	NOTCH2_uc001eil.2_Missense_Mutation_p.E253Q|NOTCH2_uc001eim.3_Missense_Mutation_p.E170Q	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	253	EGF-like 6.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGCTCCCTTCAAAACCTGGT	0.453			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.004007	0	17	63										G	120529700	C	G	120529700	3	3	6	1	0	0	0	0	1	0	0	0	10548	835	29	1	6778	1	NOTCH2	1	120529700	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7069194	120529700	128720921	39	752										
NBPF9	400818	broad.mit.edu	37	chr1	144619367	144619367	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaaatgacgaagatgaggatGaagatgttcaagttgaggag	14	2	1	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:144619367G>A	uc009wig.1	+	7	590	c.514G>A	c.(514-516)GAA>AAA	p.E172K	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.E172K|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.E103K|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.E103K|NBPF9_uc010oyg.1_Missense_Mutation_p.E137K|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	172	NBPF 1.					cytoplasm					0						AGATGAGGATGAAGATGTTCA	0.418													0	0	0	0.009718	0	34	396										A	144619367	G	A	144619367	3	1	6	1	0	0	0	0	1	0	0	0	10199	1291	45	1	526	1	NBPF9	1	144619367	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	24089667	144619367	104631254	40	753										
NBPF9	400818	broad.mit.edu	37	chr1	144619391	144619391	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgttcaagttgaggaggatGagaaagtgcagaaatcatct	12	4	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:144619391G>A	uc009wig.1	+	7	614	c.538G>A	c.(538-540)GAG>AAG	p.E180K	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.E180K|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.E111K|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.E111K|NBPF9_uc010oyg.1_Missense_Mutation_p.E145K|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	180	NBPF 1.					cytoplasm					0						TGAGGAGGATGAGAAAGTGCA	0.418													0	0	0	0.01441	0	44	431										A	144619391	G	A	144619391	3	1	6	1	0	0	0	0	1	0	0	0	10199	1291	45	1	550	1	NBPF9	1	144619391	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	24	144619391	104631230	41	754										
NBPF10	100132406	broad.mit.edu	37	chr1	146399560	146399560	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attttgtatttatagaaaatGatgaagatgaggatgaagat	10	0	0	7			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:146399560G>C	uc001emp.3	+	14	2510	c.1312G>C	c.(1312-1314)GAT>CAT	p.D438H	uc010ozk.1_5'UTR	NM_017940	NP_060410	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC55672	167											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TATAGAAAATGATGAAGATGA	0.413													0	0	0	0.007835	0	25	153										C	146399560	G	C	146399560	3	2	6	1	0	0	0	0	1	0	0	0	10193	1305	45	1		1	NBPF10	1	146399560	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1780169	146399560	102851061	42	755										
CGN	57530	broad.mit.edu	37	chr1	151498241	151498241	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtatgttccagaagaacaagGaggatcttagagccaccaag	11	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:151498241G>T	uc009wmw.2	+	9	1882	c.1738G>T	c.(1738-1740)GAG>TAG	p.E580*		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	574	Glu-rich.|Potential.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GAAGAACAAGGAGGATCTTAG	0.468													1	0	1.58986e-06	0.008291	1.61776e-06	10	45										T	151498241	G	T	151498241	4	4	6	1	0	0	0	0	0	1	0	0	3303	1175	41	3	1768	3	CGN	1	151498241	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5098681	151498241	97752380	43	756										
TCHH	7062	broad.mit.edu	37	chr1	152083887	152083887	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctctccacctcctcgcgcttCagtcgctgctcgagcctctc	7	20	3	0	rs115769840	by1000genomes	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:152083887C>T	uc001ezp.2	-	2	1806	c.1806G>A	c.(1804-1806)CTG>CTA	p.L602L	TCHH_uc009wne.1_Silent_p.L602L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	602	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTCGCGCTTCAGTCGCTGCT	0.677													0	0	0	0.012319	0	11	66										T	152083887	C	T	152083887	2	4	6	1	0	0	0	0	0	0	0	1	15697	813	29	1		1	TCHH	1	152083887	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	585646	152083887	97166734	44	757										
FLG2	388698	broad.mit.edu	37	chr1	152328793	152328793	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acccacattgtccaaagccaGaggactgacctgagccagac	9	14	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:152328793G>A	uc001ezw.3	-	3	1542	c.1469C>T	c.(1468-1470)TCT>TTT	p.S490F	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	490	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAAAGCCAGAGGACTGACC	0.527													0	0	0	0.01441	0	100	290										A	152328793	G	A	152328793	3	1	6	1	0	0	0	0	1	0	0	0	5923	942	33	1	5710	1	FLG2	1	152328793	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	244906	152328793	96921828	45	758										
SPRR2F	6705	broad.mit.edu	37	chr1	153085095	153085095	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcaggactgtggacactttgAtggtgggcagggctcagggc	18	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:153085095A>G	uc001fbi.2	-	2	174	c.115T>C	c.(115-117)TCA>CCA	p.S39P	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001014450	NP_001014450	Q96RM1	SPR2F_HUMAN	small proline-rich protein 2F	39	3 X 9 AA tandem repeats of [PS]-K-C-P- [EQ]-[PS]-C-P-P.|3.				keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGACACTTTGATGGTGGGCAG	0.632													0	0	0	0.01441	0	70	282										G	153085095	A	G	153085095	3	3	6	1	0	0	0	0	1	0	0	0	15100	333	12	5	107	5	SPRR2F	1	153085095	Missense_Mutation	SNP	A	TCGA-BT-A0YX-01A-11D-A10S-08	756302	153085095	96165526	46	759										
UBAP2L	9898	broad.mit.edu	37	chr1	154233401	154233401	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttcggccgtggggatgcctCctccccagccccggccacaa	12	18	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:154233401C>A	uc001fep.3	+	23	2779	c.2612C>A	c.(2611-2613)TCC>TAC	p.S871Y	UBAP2L_uc009wot.2_Missense_Mutation_p.S871Y|UBAP2L_uc010pek.1_Missense_Mutation_p.S863Y|UBAP2L_uc010pel.1_Missense_Mutation_p.S881Y|UBAP2L_uc010pen.1_Missense_Mutation_p.S785Y|UBAP2L_uc001feq.2_Missense_Mutation_p.S67Y|UBAP2L_uc001fer.2_Missense_Mutation_p.S67Y	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	871					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGGGATGCCTCCTCCCCAGCC	0.567													1	0	2.31682e-05	0.003163	2.34717e-05	16	80										A	154233401	C	A	154233401	3	1	6	1	0	0	0	0	1	0	0	0	16835	855	30	3	2698	3	UBAP2L	1	154233401	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1148306	154233401	95017220	47	760										
THBS3	7059	broad.mit.edu	37	chr1	155172609	155172609	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgacctccctcacctcattGatgtcactgcagtgggtgcc	9	15	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:155172609G>A	uc001fix.2	-	8	974	c.951C>T	c.(949-951)ATC>ATT	p.I317I	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Silent_p.I308I|THBS3_uc001fiz.2_Silent_p.I317I|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Silent_p.I197I|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	317	EGF-like 2; calcium-binding (Potential).				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCACCTCATTGATGTCACTGC	0.612													0	0	0	0.003755	0	34	96										A	155172609	G	A	155172609	2	1	6	1	0	0	0	0	0	0	0	1	15852	1280	45	1		1	THBS3	1	155172609	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	939208	155172609	94078012	48	761										
PKLR	5313	broad.mit.edu	37	chr1	155264172	155264172	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctcacctccaggatttcatCaaacctgagaggttgggaga	11	10	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:155264172C>T	uc001fkb.3	-	7	1009	c.970G>A	c.(970-972)GAT>AAT	p.D324N	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.D293N	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	324					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	AGGATTTCATCAAACCTGAGA	0.562													0	0	0	0.00499	0	15	51										T	155264172	C	T	155264172	3	4	6	1	0	0	0	0	1	0	0	0	11976	826	29	1	774	1	PKLR	1	155264172	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	91563	155264172	93986449	49	762										
ASH1L	55870	broad.mit.edu	37	chr1	155450350	155450350	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgtttaaggaagtcatgatCtacaaatgaagggggtccaa	12	6	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:155450350C>G	uc009wqq.2	-	3	2791	c.2311G>C	c.(2311-2313)GAT>CAT	p.D771H	ASH1L_uc001fkt.2_Missense_Mutation_p.D771H|ASH1L_uc009wqr.1_Missense_Mutation_p.D771H	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	771					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AAGTCATGATCTACAAATGAA	0.383													0	0	0	0.01441	0	53	179										G	155450350	C	G	155450350	3	3	6	1	0	0	0	0	1	0	0	0	1041	913	32	1	6687	1	ASH1L	1	155450350	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	186178	155450350	93800271	50	763										
FCRL5	83416	broad.mit.edu	37	chr1	157504671	157504671	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgagggtgaggacaggatGagacacagggactgaggaag	19	5	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:157504671G>A	uc001fqu.2	-	8	1572	c.1414C>T	c.(1414-1416)CAT>TAT	p.H472Y	FCRL5_uc009wsm.2_Missense_Mutation_p.H472Y|FCRL5_uc010phv.1_Missense_Mutation_p.H472Y|FCRL5_uc010phw.1_Missense_Mutation_p.H387Y|FCRL5_uc001fqv.1_Missense_Mutation_p.H472Y|FCRL5_uc010phx.1_Missense_Mutation_p.H223Y	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	472	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGGACAGGATGAGACACAGGG	0.493													0	0	0	0.014323	0	22	59										A	157504671	G	A	157504671	3	1	6	1	0	0	0	0	1	0	0	0	5798	1290	45	1	1559	1	FCRL5	1	157504671	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2054321	157504671	91745950	51	764										
CD1E	913	broad.mit.edu	37	chr1	158323802	158323802	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgctcctgttcctcctcttCgagggtctctgctgtcctgg	10	15	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:158323802C>G	uc001fse.2	+	1	263	c.24C>G	c.(22-24)TTC>TTG	p.F8L	CD1E_uc010pid.1_Intron|CD1E_uc010pie.1_Missense_Mutation_p.F8L|CD1E_uc010pif.1_Missense_Mutation_p.F8L|CD1E_uc001fsd.2_Missense_Mutation_p.F8L|CD1E_uc001fsk.2_Missense_Mutation_p.F8L|CD1E_uc001fsj.2_Missense_Mutation_p.F8L|CD1E_uc001fsc.2_Missense_Mutation_p.F8L|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Missense_Mutation_p.F8L|CD1E_uc001fsf.2_Missense_Mutation_p.F8L|CD1E_uc001fry.2_Missense_Mutation_p.F8L|CD1E_uc001fsg.2_Missense_Mutation_p.F8L|CD1E_uc001fsh.2_Missense_Mutation_p.F8L|CD1E_uc001fsi.2_Missense_Mutation_p.F8L|CD1E_uc009wsv.2_Missense_Mutation_p.F8L|CD1E_uc001frz.2_Missense_Mutation_p.F8L|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	8					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TCCTCCTCTTCGAGGGTCTCT	0.522													0	0	0	0.010504	0	17	72										G	158323802	C	G	158323802	3	3	6	1	0	0	0	0	1	0	0	0	2978	883	31	1	26	1	CD1E	1	158323802	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	819131	158323802	90926819	52	765										
OR10K2	391107	broad.mit.edu	37	chr1	158390393	158390393	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggaaagaaatggtcttcttCtgggacagcaggtcaaccag	12	8	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:158390393C>G	uc010pii.1	-	1	264	c.264G>C	c.(262-264)CAG>CAC	p.Q88H		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TGGTCTTCTTCTGGGACAGCA	0.478													0	0	0	0.01441	0	60	172										G	158390393	C	G	158390393	3	3	6	1	0	0	0	0	1	0	0	0	10914	912	32	1	676	1	OR10K2	1	158390393	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	66591	158390393	90860228	53	766										
PYHIN1	149628	broad.mit.edu	37	chr1	158908911	158908911	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaagagactggaaccaaaagGagtaagatgtccaaagagca	12	6	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:158908911G>C	uc001ftb.2	+	4	698	c.453G>C	c.(451-453)AGG>AGC	p.R151S	PYHIN1_uc001fta.3_Missense_Mutation_p.R151S|PYHIN1_uc001ftc.2_Missense_Mutation_p.R142S|PYHIN1_uc001ftd.2_Missense_Mutation_p.R151S|PYHIN1_uc001fte.2_Missense_Mutation_p.R142S	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	151					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					GAACCAAAAGGAGTAAGATGT	0.463													0	0	0	0.004007	0	16	49										C	158908911	G	C	158908911	3	2	6	1	0	0	0	0	1	0	0	0	12865	1165	41	1	463	1	PYHIN1	1	158908911	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	518518	158908911	90341710	54	767										
ITLN2	142683	broad.mit.edu	37	chr1	160914989	160914989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgactgcagctgctcttaaCgtgagttccatatccatccc	7	15	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:160914989C>T	uc001fxd.2	-	8	977	c.919G>A	c.(919-921)GTT>ATT	p.V307I	ITLN2_uc009wts.2_Missense_Mutation_p.V306I|ITLN2_uc010pju.1_Missense_Mutation_p.V224I	NM_080878	NP_543154	Q8WWU7	ITLN2_HUMAN	intelectin 2 precursor	307					signal transduction	extracellular region	receptor binding|sugar binding			ovary(1)	1	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CTGCTCTTAACGTGAGTTCCA	0.557													0	0	0	0.007413	0	18	65										T	160914989	C	T	160914989	3	4	6	1	0	0	0	0	1	0	0	0	7911	536	19	2	62	2	ITLN2	1	160914989	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2006078	160914989	88335632	55	768										
ADAMTS4	9507	broad.mit.edu	37	chr1	161166037	161166037	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagctccgagccgggtcacaGacggtgcccacatcagccat	11	16	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:161166037G>A	uc001fyt.3	-	3	1442	c.1014C>T	c.(1012-1014)GTC>GTT	p.V338V	ADAMTS4_uc001fyu.2_3'UTR	NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	338	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCGGGTCACAGACGGTGCCCA	0.567													0	0	0	0.00245	0	12	53										A	161166037	G	A	161166037	2	1	6	1	0	0	0	0	0	0	0	1	268	929	33	1		1	ADAMTS4	1	161166037	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	251048	161166037	88084584	56	769										
BAT2L2	23215	broad.mit.edu	37	chr1	171509701	171509701	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgaaagaggaacgggaacaGaggaaggagaaagaaggaga	17	2	0	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:171509701G>C	uc010pmg.1	+	16	3356	c.3090G>C	c.(3088-3090)CAG>CAC	p.Q1030H	BAT2L2_uc010pmh.1_Missense_Mutation_p.Q7H	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1030	Potential.						protein C-terminus binding				0						AACGGGAACAGAGGAAGGAGA	0.433													0	0	0	0.008291	0	11	43										C	171509701	G	C	171509701	3	2	6	1	0	0	0	0	1	0	0	0	1321	933	33	1	3148	1	BAT2L2	1	171509701	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	10343664	171509701	77740920	57	770										
MYOC	4653	broad.mit.edu	37	chr1	171621260	171621260	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccaacctcctggccagattCtcattttcttgccttagtcg	6	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:171621260C>T	uc001ghu.2	-	1	514	c.492G>A	c.(490-492)GAG>GAA	p.E164E	MYOC_uc010pmk.1_Silent_p.E106E	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	164	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGGCCAGATTCTCATTTTCTT	0.562													0	0	0	0.01441	0	106	414										T	171621260	C	T	171621260	2	4	6	1	0	0	0	0	0	0	0	1	10086	912	32	1		1	MYOC	1	171621260	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	111559	171621260	77629361	58	771										
ZBTB37	84614	broad.mit.edu	37	chr1	173839997	173839997	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagagagccgggagcccattCttcggatcaaccgagcagga	13	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:173839997C>G	uc009wwp.1	+	3	910	c.634C>G	c.(634-636)CTT>GTT	p.L212V	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|ZBTB37_uc001gjp.1_Missense_Mutation_p.L212V|ZBTB37_uc001gjq.3_Missense_Mutation_p.L212V|ZBTB37_uc001gjr.2_Missense_Mutation_p.L212V	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGCCCATTCTTCGGATCAA	0.532													0	0	0	0.00245	0	13	67										G	173839997	C	G	173839997	3	3	6	1	0	0	0	0	1	0	0	0	17535	913	32	1	636	1	ZBTB37	1	173839997	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2218737	173839997	75410624	59	772										
TOR1AIP1	26092	broad.mit.edu	37	chr1	179851926	179851926	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccggtccgattctgcgaaaGaggaagtgagagaaagcgcg	15	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:179851926G>A	uc001gnq.2	+	1	507	c.289G>A	c.(289-291)GAG>AAG	p.E97K	TOR1AIP1_uc001gnp.1_Missense_Mutation_p.E97K	NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	97	Nuclear (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						TTCTGCGAAAGAGGAAGTGAG	0.597													0	0	0	0.003755	0	32	77										A	179851926	G	A	179851926	3	1	6	1	0	0	0	0	1	0	0	0	16369	943	33	1	291	1	TOR1AIP1	1	179851926	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6011929	179851926	69398695	60	773										
XPR1	9213	broad.mit.edu	37	chr1	180775197	180775197	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtttctcatttctttctgtaGaatctgaattttacagggtt	7	6	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:180775197G>C	uc001goi.2	+	5	640	c.448_splice	c.e5-1	p.N150_splice	XPR1_uc009wxm.2_Splice_Site_p.N150_splice|XPR1_uc009wxn.2_Splice_Site_p.N150_splice	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor							integral to plasma membrane	G-protein coupled receptor activity				0						TCTTTCTGTAGAATCTGAATT	0.398													0	0	0	0.010729	0	11	32										C	180775197	G	C	180775197	5	2	6	1	0	0	0	0	0	0	1	0	17448	956	33	1	465	1	XPR1	1	180775197	Splice_Site	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	923271	180775197	68475424	61	774										
XPR1	9213	broad.mit.edu	37	chr1	180775240	180775240	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaaaatcctgaaaaagcatGacaagatcctggaaacatct	7	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:180775240G>C	uc001goi.2	+	5	682	c.490G>C	c.(490-492)GAC>CAC	p.D164H	XPR1_uc009wxm.2_Missense_Mutation_p.D164H|XPR1_uc009wxn.2_Missense_Mutation_p.D164H	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	164	SPX.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GAAAAAGCATGACAAGATCCT	0.383													0	0	0	0.012319	0	20	65										C	180775240	G	C	180775240	3	2	6	1	0	0	0	0	1	0	0	0	17448	1290	45	1	508	1	XPR1	1	180775240	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	43	180775240	68475381	62	775										
LAMC2	3918	broad.mit.edu	37	chr1	183194782	183194782	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aataattggagcccccagctGagttactttgagtatcgaag	10	8	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:183194782G>A	uc001gqa.2	+	8	1307	c.993G>A	c.(991-993)CTG>CTA	p.L331L	LAMC2_uc001gpz.3_Silent_p.L331L|LAMC2_uc010poa.1_Silent_p.L31L	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	331	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						GCCCCCAGCTGAGTTACTTTG	0.398													0	0	0	0.01441	0	47	153										A	183194782	G	A	183194782	2	1	6	1	0	0	0	0	0	0	0	1	8615	1277	45	1		1	LAMC2	1	183194782	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2419542	183194782	66055839	63	776										
HMCN1	83872	broad.mit.edu	37	chr1	185902803	185902803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctggcagaggaatgacagaGatgtcagactggcagagcca	14	9	1	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:185902803G>C	uc001grq.1	+	11	1904	c.1675G>C	c.(1675-1677)GAT>CAT	p.D559H		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	559	Ig-like C2-type 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAATGACAGAGATGTCAGACT	0.448													0	0	0	0.014323	0	24	54										C	185902803	G	C	185902803	3	2	6	1	0	0	0	0	1	0	0	0	7220	942	33	1	1717	1	HMCN1	1	185902803	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2708021	185902803	63347818	64	777										
TPR	7175	broad.mit.edu	37	chr1	186324879	186324879	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttttggagttgatgcaagaGaaacatcatctaagcttgaa	10	5	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:186324879G>A	uc001grv.2	-	16	2207	c.1910C>T	c.(1909-1911)TCT>TTT	p.S637F		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	637					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TGATGCAAGAGAAACATCATC	0.383			T	NTRK1	papillary thyroid								0	0	0	0.007291	0	29	102										A	186324879	G	A	186324879	3	1	6	1	0	0	0	0	1	0	0	0	16413	942	33	1	5325	1	TPR	1	186324879	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	422076	186324879	62925742	65	778										
RGS2	5997	broad.mit.edu	37	chr1	192780193	192780193	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggctggcctgtgaagacttCaaaaaaaccaaatcacccca	7	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:192780193C>G	uc001gsl.2	+	4	390	c.357C>G	c.(355-357)TTC>TTG	p.F119L		NM_002923	NP_002914	P41220	RGS2_HUMAN	regulator of G-protein signaling 2	119	RGS.				cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0						GTGAAGACTTCAAAAAAACCA	0.398													0	0	0	0.01441	0	49	117										G	192780193	C	G	192780193	3	3	6	1	0	0	0	0	1	0	0	0	13302	825	29	1	371	1	RGS2	1	192780193	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6455314	192780193	56470428	66	779										
PPP1R12B	4660	broad.mit.edu	37	chr1	202411574	202411574	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttcctttcatgcttctacaGagaatcagctgttaatctag	6	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:202411574G>A	uc001gya.1	+	12	1686	c.1542_splice	c.e12-1	p.R514_splice	PPP1R12B_uc001gxz.1_Splice_Site_p.R514_splice	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)						regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			TGCTTCTACAGAGAATCAGCT	0.443													0	0	0	0.013537	0	13	43										A	202411574	G	A	202411574	5	1	6	1	0	0	0	0	0	0	1	0	12355	956	33	1	1677	1	PPP1R12B	1	202411574	Splice_Site	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	9631381	202411574	46839047	67	780										
MYOG	4656	broad.mit.edu	37	chr1	203054957	203054957	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcaaggggccctggggcctCggggctcagggtgagctccg	18	13	2	1	rs150337281		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:203054957C>T	uc001gzd.2	-	1	421	c.133G>A	c.(133-135)GAG>AAG	p.E45K		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	45					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCTGGGGCCTCGGGGCTCAGG	0.652													0	0	0	0.004656	0	27	86										T	203054957	C	T	203054957	3	4	6	1	0	0	0	0	1	0	0	0	10090	893	31	1	553	1	MYOG	1	203054957	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	643383	203054957	46195664	68	781										
PRELP	5549	broad.mit.edu	37	chr1	203453266	203453266	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggctggaacacctgtacctCaacaacaatagcatcgagag	9	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:203453266C>G	uc001gzs.2	+	2	1154	c.954C>G	c.(952-954)CTC>CTG	p.L318L	PRELP_uc001gzt.2_Silent_p.L318L	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	318	LRR 10.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			ACCTGTACCTCAACAACAATA	0.562													0	0	0	0.003163	0	13	55										G	203453266	C	G	203453266	2	3	6	1	0	0	0	0	0	0	0	1	12473	813	29	1		1	PRELP	1	203453266	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	398309	203453266	45797355	69	782										
ATP2B4	493	broad.mit.edu	37	chr1	203667370	203667370	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cccaaaaagcccaagactttCttagaattagtgtgggaagc	9	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:203667370C>G	uc001gzw.2	+	3	1163	c.279C>G	c.(277-279)TTC>TTG	p.F93L	ATP2B4_uc001gzv.2_Missense_Mutation_p.F93L|ATP2B4_uc009xaq.2_Missense_Mutation_p.F93L	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	93	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCAAGACTTTCTTAGAATTAG	0.502													0	0	0	0.004656	0	26	83										G	203667370	C	G	203667370	3	3	6	1	0	0	0	0	1	0	0	0	1142	912	32	1	285	1	ATP2B4	1	203667370	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	214104	203667370	45583251	70	783										
ATP2B4	493	broad.mit.edu	37	chr1	203693027	203693027	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agattttcatcgtggaatttGggggtaaacccttcagttgt	11	6	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:203693027G>C	uc001gzw.2	+	19	3927	c.3043G>C	c.(3043-3045)GGG>CGG	p.G1015R	ATP2B4_uc001gzv.2_Missense_Mutation_p.G1015R|ATP2B4_uc009xaq.2_Missense_Mutation_p.G1015R|ATP2B4_uc001gzx.2_Missense_Mutation_p.G46R|ATP2B4_uc009xar.2_Intron	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1015	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CGTGGAATTTGGGGGTAAACC	0.542													0	0	0	0.004656	0	24	65										C	203693027	G	C	203693027	3	2	6	1	0	0	0	0	1	0	0	0	1142	1348	47	4	3113	4	ATP2B4	1	203693027	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	25657	203693027	45557594	71	784										
PPP1R15B	84919	broad.mit.edu	37	chr1	204379015	204379015	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agacaaatccttctctgaatCagaaggctcttcaggaacaa	7	10	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:204379015C>G	uc001hav.3	-	1	1930	c.1525G>C	c.(1525-1527)GAT>CAT	p.D509H		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	509					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			TTCTCTGAATCAGAAGGCTCT	0.463													0	0	0	0.00278	0	25	77										G	204379015	C	G	204379015	3	3	6	1	0	0	0	0	1	0	0	0	12364	826	29	1	624	1	PPP1R15B	1	204379015	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	685988	204379015	44871606	72	785										
PPP1R15B	84919	broad.mit.edu	37	chr1	204379192	204379192	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accatcatcctcagcttcctCatcccaatcctcaccttctg	2	19	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:204379192C>T	uc001hav.3	-	1	1753	c.1348G>A	c.(1348-1350)GAG>AAG	p.E450K		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	450					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			TCAGCTTCCTCATCCCAATCC	0.458													0	0	0	0.01441	0	48	218										T	204379192	C	T	204379192	3	4	6	1	0	0	0	0	1	0	0	0	12364	835	29	1	801	1	PPP1R15B	1	204379192	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	177	204379192	44871429	73	786										
PPP1R15B	84919	broad.mit.edu	37	chr1	204379760	204379760	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggatgacaatggtcctctctCaggcagctgctctctggggt	13	11	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:204379760C>A	uc001hav.3	-	1	1185	c.780G>T	c.(778-780)CTG>CTT	p.L260L		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	260					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			GGTCCTCTCTCAGGCAGCTGC	0.542													1	0	6.03168e-27	0.004878	6.28921e-27	35	138										A	204379760	C	A	204379760	2	1	6	1	0	0	0	0	0	0	0	1	12364	813	29	3		3	PPP1R15B	1	204379760	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	568	204379760	44870861	74	787										
LOC642587	642587	broad.mit.edu	37	chr1	209605571	209605571	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcagtggagtgaagttcagGaggcatggagctgacaacca	14	7	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:209605571G>C	uc009xcn.2	+	4	569	c.186G>C	c.(184-186)AGG>AGC	p.R62S	LOC642587_uc010psk.1_RNA|MIR205_hsa-mir-205|MI0000285_RNA	NM_001104548	NP_001098018			hypothetical protein LOC642587												0				OV - Ovarian serous cystadenocarcinoma(81;0.0422)		TGAAGTTCAGGAGGCATGGAG	0.299													0	0	0	0.001168	0	6	32										C	209605571	G	C	209605571	3	2	6	1	0	0	0	0	1	0	0	0	8882	1165	41	1	196	1	LOC642587	1	209605571	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5225811	209605571	39645050	75	788										
SERTAD4	56256	broad.mit.edu	37	chr1	210411352	210411352	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attctgcgagcccattgtctCggaaggagctgctgaaattg	12	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:210411352C>T	uc001hhy.2	+	2	226	c.47C>T	c.(46-48)TCG>TTG	p.S16L	SERTAD4_uc009xcw.2_Missense_Mutation_p.S16L	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	16							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CCCATTGTCTCGGAAGGAGCT	0.488													0	0	0	0.005524	0	33	124										T	210411352	C	T	210411352	3	4	6	1	0	0	0	0	1	0	0	0	14123	893	31	1	49	1	SERTAD4	1	210411352	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	805781	210411352	38839269	76	789										
FLVCR1	28982	broad.mit.edu	37	chr1	213032118	213032118	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgctctccccgcggcgcttCgtggtgctcctgatcttcag	12	16	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:213032118C>A	uc001hjt.2	+	1	522	c.324C>A	c.(322-324)TTC>TTA	p.F108L	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	108	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		CGCGGCGCTTCGTGGTGCTCC	0.657													1	0	2.31682e-05	0.003163	2.34717e-05	14	27										A	213032118	C	A	213032118	3	1	6	1	0	0	0	0	1	0	0	0	5945	883	31	3	326	3	FLVCR1	1	213032118	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2620766	213032118	36218503	77	790										
KCNK2	3776	broad.mit.edu	37	chr1	215256745	215256745	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctcatgcttcccagcgcctCgcgggagagacccggctata	11	16	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:215256745C>G	uc001hkq.2	+	1	186	c.17C>G	c.(16-18)TCG>TGG	p.S6W	KCNK2_uc001hko.2_Intron|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_Intron|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Intron	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	6	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCCAGCGCCTCGCGGGAGAGA	0.547													0	0	0	0.00632	0	25	90										G	215256745	C	G	215256745	3	3	6	1	0	0	0	0	1	0	0	0	8066	893	31	1	62	1	KCNK2	1	215256745	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2224627	215256745	33993876	78	791										
EPRS	2058	broad.mit.edu	37	chr1	220213549	220213549	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaaacatgaagaatattctCtttcccttcttcaacggaaa	5	9	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:220213549C>G	uc001hly.1	-	2	379	c.109G>C	c.(109-111)GAG>CAG	p.E37Q	EPRS_uc010puf.1_5'UTR|EPRS_uc001hlz.1_Missense_Mutation_p.E37Q|EPRS_uc009xdt.1_5'UTR	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	37					glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AGAATATTCTCTTTCCCTTCT	0.269													0	0	0	0.00333	0	20	130										G	220213549	C	G	220213549	3	3	6	1	0	0	0	0	1	0	0	0	5191	922	32	1	4553	1	EPRS	1	220213549	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4956804	220213549	29037072	79	792										
HLX	3142	broad.mit.edu	37	chr1	221053221	221053221	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgttcgcagccgggctggctCccttctacgcctccaacttc	9	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:221053221C>T	uc001hmv.3	+	1	479	c.22C>T	c.(22-24)CCC>TCC	p.P8S		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	8					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		CGGGCTGGCTCCCTTCTACGC	0.731													0	0	0	0.000602	0	5	9										T	221053221	C	T	221053221	3	4	6	1	0	0	0	0	1	0	0	0	7216	855	30	1	24	1	HLX	1	221053221	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	839672	221053221	28197400	80	793										
C1orf55	163859	broad.mit.edu	37	chr1	226180638	226180638	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctccttccactgagatcccGacaagcttctcgattggttg	8	13	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:226180638G>A	uc001hpu.3	-	3	357	c.304C>T	c.(304-306)CGG>TGG	p.R102W	C1orf55_uc001hpv.2_Missense_Mutation_p.R102W	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	102										lung(1)	1	Breast(184;0.197)					CTGAGATCCCGACAAGCTTCT	0.423													0	0	0	0.005524	0	31	68										A	226180638	G	A	226180638	3	1	6	1	0	0	0	0	1	0	0	0	2047	1057	37	1	1071	1	C1orf55	1	226180638	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5127417	226180638	23069983	81	794										
CDC42BPA	8476	broad.mit.edu	37	chr1	227261667	227261667	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgactgcaactccagtctaGctgacatatccagtttcgca	7	14	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:227261667G>C	uc001hqr.2	-	19	3576	c.2633C>G	c.(2632-2634)GCT>GGT	p.A878G	CDC42BPA_uc001hqq.2_Missense_Mutation_p.A142G|CDC42BPA_uc001hqs.2_Missense_Mutation_p.A797G|CDC42BPA_uc009xes.2_Missense_Mutation_p.A878G|CDC42BPA_uc010pvs.1_Missense_Mutation_p.A878G|CDC42BPA_uc001hqp.2_Missense_Mutation_p.A34G|CDC42BPA_uc001hqu.1_Missense_Mutation_p.A34G	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	878					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTCCAGTCTAGCTGACATATC	0.368													0	0	0	0.01441	0	52	154										C	227261667	G	C	227261667	3	2	6	1	0	0	0	0	1	0	0	0	3072	971	34	4	2598	4	CDC42BPA	1	227261667	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1081029	227261667	21988954	82	795										
ARID4B	51742	broad.mit.edu	37	chr1	235357527	235357527	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttttctttgtctaatttattCtaggttaagaaaaaaagtat	5	3	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:235357527C>G	uc001hwq.2	-	19	2425	c.1927_splice	c.e19-1	p.N643_splice	ARID4B_uc001hwr.2_Splice_Site_p.N557_splice|ARID4B_uc001hws.3_Splice_Site_p.N557_splice|ARID4B_uc001hwp.2_Splice_Site|ARID4B_uc001hwt.3_Splice_Site_p.N324_splice	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			CTAATTTATTCTAGGTTAAGA	0.303													0	0	0	0.006214	0	10	42										G	235357527	C	G	235357527	5	3	6	1	0	0	0	0	0	0	1	0	920	927	32	1	2036	1	ARID4B	1	235357527	Splice_Site	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	8095860	235357527	13893094	83	796										
RYR2	6262	broad.mit.edu	37	chr1	237774219	237774219	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtgtctcgaataagtgaacGccaaggctggttggtgcagt	14	7	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:237774219G>A	uc001hyl.1	+	36	4961	c.4841G>A	c.(4840-4842)CGC>CAC	p.R1614H		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1614	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATAAGTGAACGCCAAGGCTGG	0.527													0	0	0	0.00308	0	8	25										A	237774219	G	A	237774219	3	1	6	1	0	0	0	0	1	0	0	0	13769	1087	38	2	4983	2	RYR2	1	237774219	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2416692	237774219	11476402	84	797										
WDR64	128025	broad.mit.edu	37	chr1	241964444	241964444	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tatttcacaggcaccacgaaGaagaagtttgaaaaaaaatt	7	6	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:241964444G>C	uc001hzf.1	+	17	1985	c.1832G>C	c.(1831-1833)AGA>ACA	p.R611T	WDR64_uc001hzg.1_Missense_Mutation_p.R524T	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	1058										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			GCACCACGAAGAAGAAGTTTG	0.378													0	0	0	0.012319	0	22	70										C	241964444	G	C	241964444	3	2	6	1	0	0	0	0	1	0	0	0	17312	942	33	1	3279	1	WDR64	1	241964444	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4190225	241964444	7286177	85	798										
CEP170	9859	broad.mit.edu	37	chr1	243328908	243328908	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatttttttctggaggttgtGattcttgtttaaaagtttcc	8	4	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr1:243328908G>C	uc001hzs.2	-	13	2762	c.2354C>G	c.(2353-2355)TCA>TGA	p.S785*	CEP170_uc001hzt.2_Nonsense_Mutation_p.S687*|CEP170_uc001hzu.2_Nonsense_Mutation_p.S687*|CEP170_uc001hzv.1_Nonsense_Mutation_p.S163*	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	785						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TGGAGGTTGTGATTCTTGTTT	0.398													0	0	0	0.007413	0	17	133										C	243328908	G	C	243328908	4	2	6	1	0	0	0	0	0	1	0	0	3250	1294	45	1	2462	1	CEP170	1	243328908	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1364464	243328908	5921713	86	799										
MYT1L	23040	broad.mit.edu	37	chr2	1914091	1914091	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgtgccttggccagtttctCtgctgcagcgatcgggcatc	12	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:1914091C>G	uc002qxe.2	-	13	2565	c.1738G>C	c.(1738-1740)GAG>CAG	p.E580Q	MYT1L_uc002qxd.2_Missense_Mutation_p.E578Q|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	580					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCCAGTTTCTCTGCTGCAGCG	0.592													0	0	0	0.001168	0	5	65										G	1914091	C	G	1914091	3	3	6	1	0	0	0	0	1	0	0	0	10107	922	32	1	1874	1	MYT1L	2	1914091	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		1914091	241285282	87	800										
TP53I3	9540	broad.mit.edu	37	chr2	24300523	24300523	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttatgggcctcctggatttCggtcactgggtagattctgt	12	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:24300523C>T	uc002rey.1	-	6	985	c.925G>A	c.(925-927)GAA>AAA	p.E309K	LOC375190_uc002rew.2_Intron|SF3B14_uc002rev.2_5'Flank|SF3B14_uc010eyb.2_5'Flank|TP53I3_uc002rex.1_Missense_Mutation_p.R243Q|TP53I3_uc002rez.1_Missense_Mutation_p.E309K|TP53I3_uc010ykk.1_Missense_Mutation_p.E220K	NM_147184	NP_671713	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	309					induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTGGATTTCGGTCACTGGG	0.562													0	0	0	0.01441	0	61	90										T	24300523	C	T	24300523	3	4	6	1	0	0	0	0	1	0	0	0	16384	893	31	1	77	1	TP53I3	2	24300523	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	22386432	24300523	218898850	88	801										
ASXL2	55252	broad.mit.edu	37	chr2	25976464	25976464	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctccacttttttctccttctCaatctcttgtcgaattctca	2	14	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:25976464C>G	uc002rgs.2	-	10	1302	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q	ASXL2_uc002rgt.1_Missense_Mutation_p.E101Q	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTCCTTCTCAATCTCTTGT	0.363													0	0	0	0.01441	0	54	240										G	25976464	C	G	25976464	3	3	6	1	0	0	0	0	1	0	0	0	1067	835	29	1	3238	1	ASXL2	2	25976464	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1675941	25976464	217222909	89	802										
C2orf16	84226	broad.mit.edu	37	chr2	27801442	27801442	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attaacctcaccgcaaacatCtccatttgaggaacatacaa	4	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:27801442C>T	uc002rkz.3	+	1	2054	c.2003C>T	c.(2002-2004)TCT>TTT	p.S668F		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	668										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CCGCAAACATCTCCATTTGAG	0.408													0	0	0	0.01441	0	72	103										T	27801442	C	T	27801442	3	4	6	1	0	0	0	0	1	0	0	0	2157	913	32	1	2005	1	C2orf16	2	27801442	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1824978	27801442	215397931	90	803										
FOSL2	2355	broad.mit.edu	37	chr2	28616622	28616622	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcccgggaactttgacacctCgtcccggggcagcagcggct	13	15	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:28616622C>G	uc002rma.2	+	1	844	c.35C>G	c.(34-36)TCG>TGG	p.S12W	uc002rlz.1_Intron|FOSL2_uc010ymi.1_5'Flank	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	12					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					TTTGACACCTCGTCCCGGGGC	0.716													0	0	0	0.00308	0	7	9										G	28616622	C	G	28616622	3	3	6	1	0	0	0	0	1	0	0	0	5988	893	31	1	37	1	FOSL2	2	28616622	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	815180	28616622	214582751	91	804										
CCDC75	253635	broad.mit.edu	37	chr2	37319356	37319356	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgaagctagaaggagatctCagaagaagccagcgagcctg	13	8	1	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:37319356C>G	uc010ezz.2	+	6	631	c.486C>G	c.(484-486)CTC>CTG	p.L162L	CCDC75_uc002rpr.3_Silent_p.L59L	NM_174931	NP_777591	Q8N954	CCD75_HUMAN	coiled-coil domain containing 75	162						intracellular	nucleic acid binding				0		all_hematologic(82;0.21)				AAGGAGATCTCAGAAGAAGCC	0.378													0	0	0	0.004672	0	3	11										G	37319356	C	G	37319356	2	3	6	1	0	0	0	0	0	0	0	1	2849	813	29	1		1	CCDC75	2	37319356	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	8702734	37319356	205880017	92	805										
SOS1	6654	broad.mit.edu	37	chr2	39213087	39213087	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgagaagtgctttgtcgtgGaggaacaggcggcccagcaa	15	8	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:39213087G>C	uc002rrk.3	-	23	3921	c.3880C>G	c.(3880-3882)CCA>GCA	p.P1294A	SOS1_uc002rrj.3_Missense_Mutation_p.P893A	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	1294					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CTTTGTCGTGGAGGAACAGGC	0.502									Noonan_syndrome				0	0	0	0.01441	0	94	204										C	39213087	G	C	39213087	3	2	6	1	0	0	0	0	1	0	0	0	14936	1174	41	1	125	1	SOS1	2	39213087	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1893731	39213087	203986286	93	806										
ALMS1	7840	broad.mit.edu	37	chr2	73677000	73677000	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaccttgccagagagtcatCtgcctaaagaggctctgaaa	10	10	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:73677000C>G	uc002sje.1	+	10	3460	c.3349C>G	c.(3349-3351)CTG>GTG	p.L1117V	ALMS1_uc002sjf.1_Missense_Mutation_p.L1073V|ALMS1_uc002sjg.2_Missense_Mutation_p.L503V|ALMS1_uc002sjh.1_Missense_Mutation_p.L503V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1115	34 X 47 AA approximate tandem repeat.|13.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AGAGAGTCATCTGCCTAAAGA	0.468													0	0	0	0.01441	0	81	231										G	73677000	C	G	73677000	3	3	6	1	0	0	0	0	1	0	0	0	535	912	32	1	3373	1	ALMS1	2	73677000	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	34463913	73677000	169522373	94	807										
MOGS	7841	broad.mit.edu	37	chr2	74689052	74689052	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcccagctcagcagctacctCagcctcacccagatgctctg	8	18	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:74689052C>T	uc010ffj.2	-	4	2027	c.1864G>A	c.(1864-1866)GAG>AAG	p.E622K	MOGS_uc010ffh.2_Missense_Mutation_p.E347K|MOGS_uc010yrt.1_Missense_Mutation_p.E503K|MOGS_uc010ffi.2_Missense_Mutation_p.E516K	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	622	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GCAGCTACCTCAGCCTCACCC	0.632													0	0	0	0.006122	0	13	53										T	74689052	C	T	74689052	3	4	6	1	0	0	0	0	1	0	0	0	9697	835	29	1	653	1	MOGS	2	74689052	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1012052	74689052	168510321	95	808										
MRPL53	116540	broad.mit.edu	37	chr2	74699247	74699247	+	Nonstop_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttggtctctttggcgctgtCagcgaccagtatcagcgccc	12	13	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:74699247C>A	uc002sln.2	-	3	478	c.338G>T	c.(337-339)TGA>TTA	p.*113L	CCDC142_uc002slo.2_RNA	NM_053050	NP_444278	Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53 precursor	113						mitochondrion|ribosome					0						TTGGCGCTGTCAGCGACCAGT	0.547													1	0	2.44723e-14	0.004656	2.52899e-14	26	84										A	74699247	C	A	74699247	4	1	6	1	0	0	0	0	0	0	0	0	9817	837	29	3	4	3	MRPL53	2	74699247	Nonstop_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	10195	74699247	168500126	96	809										
HK2	3099	broad.mit.edu	37	chr2	75061718	75061718	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgcggcaggatgattgcctCgcatctgcttgcctacttct	10	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:75061718C>G	uc002snd.2	+	1	1937	c.11C>G	c.(10-12)TCG>TGG	p.S4W		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	4	Hydrophobic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						ATGATTGCCTCGCATCTGCTT	0.662													0	0	0	0.006122	0	16	50										G	75061718	C	G	75061718	3	3	6	1	0	0	0	0	1	0	0	0	7191	893	31	1	13	1	HK2	2	75061718	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	362471	75061718	168137655	97	810										
PROM2	150696	broad.mit.edu	37	chr2	95941808	95941808	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgcgggggacgagtgaagaCagagcacaaggcgctggcct	17	10	0	3	rs147971761		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:95941808C>A	uc002suh.1	+	3	558	c.425C>A	c.(424-426)ACA>AAA	p.T142K	PROM2_uc002sui.2_Missense_Mutation_p.T142K|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Missense_Mutation_p.T142K|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	142	Cytoplasmic (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						CGAGTGAAGACAGAGCACAAG	0.687													1	0	0.000442599	0.006214	0.000447421	9	39										A	95941808	C	A	95941808	3	1	6	1	0	0	0	0	1	0	0	0	12556	478	17	4	435	4	PROM2	2	95941808	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	20880090	95941808	147257565	98	811										
SNRNP200	23020	broad.mit.edu	37	chr2	96952861	96952861	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aacagatggacatatttgtgGatggtcttccccatctttgg	10	8	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:96952861G>A	uc002svu.2	-	27	3608	c.3522C>T	c.(3520-3522)ATC>ATT	p.I1174I	SNRNP200_uc002svt.2_5'Flank|SNRNP200_uc010yuj.1_5'Flank|SNRNP200_uc002svv.1_5'Flank|SNRNP200_uc002svw.1_Silent_p.I246I	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1174	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CATATTTGTGGATGGTCTTCC	0.537													0	0	0	0.01441	0	58	149										A	96952861	G	A	96952861	2	1	6	1	0	0	0	0	0	0	0	1	14852	1164	41	1		1	SNRNP200	2	96952861	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1011053	96952861	146246512	99	812										
CNNM3	26505	broad.mit.edu	37	chr2	97494773	97494773	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caatgcactcctggctacccGagcccagaacctgccacagt	8	17	0	1	rs149301704		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:97494773G>A	uc002swy.2	+	7	1985	c.1961G>A	c.(1960-1962)CGA>CAA	p.R654Q	CNNM3_uc002swz.2_Missense_Mutation_p.R606Q	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	654					ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						CTGGCTACCCGAGCCCAGAAC	0.587													0	0	0	0.00333	0	25	38										A	97494773	G	A	97494773	3	1	6	1	0	0	0	0	1	0	0	0	3614	1058	37	1	1987	1	CNNM3	2	97494773	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	541912	97494773	145704600	100	813										
EIF5B	9669	broad.mit.edu	37	chr2	100011209	100011209	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtaattttggccttcgatgtGagaattgaacgagatgcaca	11	6	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:100011209G>C	uc002tab.2	+	21	3301	c.3117G>C	c.(3115-3117)GTG>GTC	p.V1039V	EIF5B_uc010yvq.1_Silent_p.V21V	NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	1039					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						CCTTCGATGTGAGAATTGAAC	0.318													0	0	0	0.007291	0	26	121										C	100011209	G	C	100011209	2	2	6	1	0	0	0	0	0	0	0	1	5044	1277	45	1		1	EIF5B	2	100011209	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2516436	100011209	143188164	101	814										
IL1RL1	9173	broad.mit.edu	37	chr2	102956721	102956721	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acaactggacagcacctcttGagtggtttaaggtaagaaga	11	7	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:102956721G>C	uc002tbu.1	+	4	707	c.436G>C	c.(436-438)GAG>CAG	p.E146Q	IL1RL1_uc010ywa.1_Missense_Mutation_p.E29Q|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.E146Q	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	146	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						AGCACCTCTTGAGTGGTTTAA	0.274													0	0	0	0.001855	0	12	62										C	102956721	G	C	102956721	3	2	6	1	0	0	0	0	1	0	0	0	7663	1291	45	1	446	1	IL1RL1	2	102956721	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2945512	102956721	140242652	102	815										
SLC9A4	389015	broad.mit.edu	37	chr2	103119999	103119999	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctggatgtgcccgattcatCgttgtggggcttggaggggt	18	7	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:103119999C>T	uc002tbz.3	+	3	1270	c.813C>T	c.(811-813)ATC>ATT	p.I271I		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	271	Helical; Name=H/M6; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CCCGATTCATCGTTGTGGGGC	0.393													0	0	0	0.003954	0	24	69										T	103119999	C	T	103119999	2	4	6	1	0	0	0	0	0	0	0	1	14716	874	31	1		1	SLC9A4	2	103119999	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	163278	103119999	140079374	103	816										
GYPC	2995	broad.mit.edu	37	chr2	127453717	127453717	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagaaaggagtactttatttGagggacaacagacttcactt	9	7	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:127453717G>A	uc002tnq.2	+	4	542	c.386G>A	c.(385-387)TGA>TAA	p.*129*	GYPC_uc002tnr.2_Silent_p.*110*|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	129						cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		TACTTTATTTGAGGGACAACA	0.552													0	0	0	0.006214	0	10	34										A	127453717	G	A	127453717	2	1	6	1	0	0	0	0	0	0	0	1	6910	1285	45	1		1	GYPC	2	127453717	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	24333718	127453717	115745656	104	817										
GPR17	2840	broad.mit.edu	37	chr2	128408370	128408370	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acttctccctggccacggcaGagcaatgtggccaggagacg	13	13	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:128408370G>C	uc010yzn.1	+	4	756	c.145G>C	c.(145-147)GAG>CAG	p.E49Q	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Missense_Mutation_p.E49Q|GPR17_uc010yzo.1_Missense_Mutation_p.E21Q|GPR17_uc002tpd.2_Missense_Mutation_p.E21Q	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	49	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		ggccacggcagagcaatgtgg	0.08											OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	31	127										C	128408370	G	C	128408370	3	2	6	1	0	0	0	0	1	0	0	0	6667	943	33	1	151	1	GPR17	2	128408370	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	954653	128408370	114791003	105	818										
NR4A2	4929	broad.mit.edu	37	chr2	157186256	157186256	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctggtggaagttgtggagaGatcccgggtcgtcccacatg	15	9	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:157186256G>C	uc002tyz.3	-	3	865	c.443C>G	c.(442-444)TCT>TGT	p.S148C	NR4A2_uc002tyx.3_Missense_Mutation_p.S85C|NR4A2_uc010zcf.1_Missense_Mutation_p.S148C|NR4A2_uc010zcg.1_5'Flank	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	148	Pro-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GTTGTGGAGAGATCCCGGGTC	0.622													0	0	0	0.01441	0	51	157										C	157186256	G	C	157186256	3	2	6	1	0	0	0	0	1	0	0	0	10633	942	33	1	1377	1	NR4A2	2	157186256	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	28777886	157186256	86013117	106	819										
GALNT5	11227	broad.mit.edu	37	chr2	158115547	158115547	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgggaagaaactcaatttctCtgaaagccatcttgtgatta	8	7	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:158115547C>T	uc002tzg.2	+	1	1208	c.953C>T	c.(952-954)TCT>TTT	p.S318F	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	318	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						CTCAATTTCTCTGAAAGCCAT	0.388													0	0	0	0.009535	0	31	93										T	158115547	C	T	158115547	3	4	6	1	0	0	0	0	1	0	0	0	6216	913	32	1	955	1	GALNT5	2	158115547	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	929291	158115547	85083826	107	820										
SLC4A10	57282	broad.mit.edu	37	chr2	162833271	162833271	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggggaaactcctgtctagaGatgatccatctgtgatcaat	10	8	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:162833271G>C	uc002ubx.3	+	25	3413	c.3229G>C	c.(3229-3231)GAT>CAT	p.D1077H	SLC4A10_uc002uby.3_Missense_Mutation_p.D1047H|SLC4A10_uc010zcs.1_Missense_Mutation_p.D1058H	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	1077	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CCTGTCTAGAGATGATCCATC	0.348													0	0	0	0.004672	0	2	8										C	162833271	G	C	162833271	3	2	6	1	0	0	0	0	1	0	0	0	14651	956	33	1	3412	1	SLC4A10	2	162833271	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4717724	162833271	80366102	108	821										
SCN3A	6328	broad.mit.edu	37	chr2	165956815	165956815	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgtctattcttcttaccctCatgccttcaaaccgggataa	6	12	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:165956815C>T	uc002ucx.2	-	22	4455	c.3963G>A	c.(3961-3963)ATG>ATA	p.M1321I	SCN3A_uc002ucy.2_Missense_Mutation_p.M1272I|SCN3A_uc002ucz.2_Missense_Mutation_p.M1272I|SCN3A_uc002uda.1_Missense_Mutation_p.M1141I|SCN3A_uc002udb.1_Missense_Mutation_p.M1141I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1321						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTCTTACCCTCATGCCTTCAA	0.373													0	0	0	0.004878	0	35	117										T	165956815	C	T	165956815	3	4	6	1	0	0	0	0	1	0	0	0	13918	826	29	1	2067	1	SCN3A	2	165956815	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3123544	165956815	77242558	109	822										
XIRP2	129446	broad.mit.edu	37	chr2	167992460	167992460	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgtgctcgccagcttttaaGagtcaccctgggagccagct	11	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:167992460G>C	uc002udx.2	+	2	468	c.450G>C	c.(448-450)AAG>AAC	p.K150N	XIRP2_uc010fpn.2_Missense_Mutation_p.K150N|XIRP2_uc010fpo.2_Missense_Mutation_p.K150N|XIRP2_uc010fpp.2_Missense_Mutation_p.K150N|XIRP2_uc002udy.2_5'UTR	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAGCTTTTAAGAGTCACCCTG	0.433													0	0	0	0.012319	0	21	67										C	167992460	G	C	167992460	3	2	6	1	0	0	0	0	1	0	0	0	17427	933	33	1	456	1	XIRP2	2	167992460	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2035645	167992460	75206913	110	823										
LRP2	4036	broad.mit.edu	37	chr2	170083085	170083085	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgttgccttacagttattaaGaaaggttgatcatctgtgaa	9	5	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:170083085G>A	uc002ues.2	-	32	5454	c.5241C>T	c.(5239-5241)TTC>TTT	p.F1747F		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1747	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAGTTATTAAGAAAGGTTGAT	0.378													0	0	0	0.004007	0	17	64										A	170083085	G	A	170083085	2	1	6	1	0	0	0	0	0	0	0	1	8956	933	33	1		1	LRP2	2	170083085	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2090625	170083085	73116288	111	824										
KBTBD10	10324	broad.mit.edu	37	chr2	170367164	170367164	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gatttacttcctggttacctGaatgacattcccaggcatgg	9	10	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:170367164G>A	uc002ueu.1	+	1	953	c.876G>A	c.(874-876)CTG>CTA	p.L292L	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	292					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						CTGGTTACCTGAATGACATTC	0.478													0	0	0	0.010504	0	22	63										A	170367164	G	A	170367164	2	1	6	1	0	0	0	0	0	0	0	1	7990	1277	45	1		1	KBTBD10	2	170367164	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	284079	170367164	72832209	112	825										
DLX2	1746	broad.mit.edu	37	chr2	172965328	172965328	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgccgtgatggtggtggtgGtgatgcggctgcggggtctg	21	8	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:172965328G>C	uc002uhn.2	-	3	1142	c.930C>G	c.(928-930)CAC>CAG	p.H310Q		NM_004405	NP_004396	Q07687	DLX2_HUMAN	distal-less homeobox 2	310	Poly-His.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GGTGGTGGTGGTGATGCGGCT	0.672													0	0	0	0.001984	0	6	38										C	172965328	G	C	172965328	3	2	6	1	0	0	0	0	1	0	0	0	4571	1252	44	4	60	4	DLX2	2	172965328	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2598164	172965328	70234045	113	826										
NFE2L2	4780	broad.mit.edu	37	chr2	178098975	178098975	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagatctatatcttgcctccAaagtatgtcaatcaaatcca	4	10	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:178098975A>G	uc002ulh.3	-	2	625	c.70T>C	c.(70-72)TGG>CGG	p.W24R	NFE2L2_uc002ulg.3_Missense_Mutation_p.W8R|NFE2L2_uc010zfa.1_Missense_Mutation_p.W8R|NFE2L2_uc002uli.3_Missense_Mutation_p.W8R|NFE2L2_uc010fra.2_Missense_Mutation_p.W8R|NFE2L2_uc010frb.2_Missense_Mutation_p.W8R	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	24					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCTTGCCTCCAAAGTATGTCA	0.348			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.004482	0	8	64										G	178098975	A	G	178098975	3	3	6	1	0	0	0	0	1	0	0	0	10368	130	5	5	1763	5	NFE2L2	2	178098975	Missense_Mutation	SNP	A	TCGA-BT-A0YX-01A-11D-A10S-08	5133647	178098975	65100398	114	827										
TTN	7273	broad.mit.edu	37	chr2	179472934	179472934	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	catgtgctgttttgggatctGaaggtggactgaactttcca	12	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:179472934G>A	uc010zfg.1	-	224	45196	c.44972C>T	c.(44971-44973)TCA>TTA	p.S14991L	uc002ump.1_RNA|TTN_uc010zfh.1_Missense_Mutation_p.S8686L|TTN_uc010zfi.1_Missense_Mutation_p.S8619L|TTN_uc010zfj.1_Missense_Mutation_p.S8494L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15918							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGGATCTGAAGGTGGACT	0.418													0	0	0	0.006214	0	9	21										A	179472934	G	A	179472934	3	1	6	1	0	0	0	0	1	0	0	0	16732	1294	45	1	55369	1	TTN	2	179472934	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1373959	179472934	63726439	115	828										
TTN	7273	broad.mit.edu	37	chr2	179583286	179583286	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aactatggggcttcctgtctCaacactgaaatcagccaatc	7	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:179583286C>G	uc010zfg.1	-	82	21039	c.20815G>C	c.(20815-20817)GAG>CAG	p.E6939Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E3600Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7866							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCCTGTCTCAACACTGAAA	0.423													0	0	0	0.004482	0	9	49										G	179583286	C	G	179583286	3	3	6	1	0	0	0	0	1	0	0	0	16732	835	29	1	80094	1	TTN	2	179583286	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	110352	179583286	63616087	116	829										
TTN	7273	broad.mit.edu	37	chr2	179598113	179598113	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tattcggtattttttactggCgaccaagggtctcccatctt	8	10	2	0	rs72648934		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:179598113C>T	uc010zfg.1	-	51	12399	c.12175G>A	c.(12175-12177)GCC>ACC	p.A4059T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A720T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4986							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTACTGGCGACCAAGGGT	0.473													0	0	0	0.005524	0	41	127										T	179598113	C	T	179598113	3	4	6	1	0	0	0	0	1	0	0	0	16732	768	27	2	88858	2	TTN	2	179598113	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	14827	179598113	63601260	117	830										
NEUROD1	4760	broad.mit.edu	37	chr2	182543515	182543515	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtcctgagaactgagacactCgtctgtccagcttggaggac	12	11	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:182543515C>G	uc002uof.2	-	2	309	c.73G>C	c.(73-75)GAG>CAG	p.E25Q	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	25					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTGAGACACTCGTCTGTCCAG	0.552													0	0	0	0.003954	0	20	57										G	182543515	C	G	182543515	3	3	6	1	0	0	0	0	1	0	0	0	10348	893	31	1	1001	1	NEUROD1	2	182543515	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2945402	182543515	60655858	118	831										
PDE1A	5136	broad.mit.edu	37	chr2	183095762	183095762	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttgaaacggttgataagatCatatctggtaaacagttcat	8	6	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:183095762C>T	uc002uos.2	-	6	646	c.562G>A	c.(562-564)GAT>AAT	p.D188N	PDE1A_uc010zfp.1_Missense_Mutation_p.D84N|PDE1A_uc002uoq.1_Missense_Mutation_p.D188N|PDE1A_uc010zfq.1_Missense_Mutation_p.D188N|PDE1A_uc002uor.2_Missense_Mutation_p.D172N|PDE1A_uc002uou.2_Missense_Mutation_p.D154N	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	188					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TTGATAAGATCATATCTGGTA	0.338													0	0	0	0.00874	0	41	131										T	183095762	C	T	183095762	3	4	6	1	0	0	0	0	1	0	0	0	11633	826	29	1	1163	1	PDE1A	2	183095762	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	552247	183095762	60103611	119	832										
FAM171B	165215	broad.mit.edu	37	chr2	187626715	187626715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaaacatctgaccttttctCcacaccggaacaattacata	3	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:187626715C>T	uc002ups.2	+	8	1758	c.1646C>T	c.(1645-1647)TCC>TTC	p.S549F	FAM171B_uc002upr.1_Missense_Mutation_p.S516F|FAM171B_uc002upt.2_Missense_Mutation_p.S18F	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	549	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						GACCTTTTCTCCACACCGGAA	0.438													0	0	0	0.004007	0	14	55										T	187626715	C	T	187626715	3	4	6	1	0	0	0	0	1	0	0	0	5491	855	30	1	1676	1	FAM171B	2	187626715	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4530953	187626715	55572658	120	833										
FAM171B	165215	broad.mit.edu	37	chr2	187626819	187626819	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taaatcgagagaactttacgCagaccttgcccaaaatgcca	7	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:187626819C>G	uc002ups.2	+	8	1862	c.1750C>G	c.(1750-1752)CAG>GAG	p.Q584E	FAM171B_uc002upr.1_Missense_Mutation_p.Q551E|FAM171B_uc002upt.2_Missense_Mutation_p.Q53E	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	584	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						GAACTTTACGCAGACCTTGCC	0.473													0	0	0	0.00499	0	17	69										G	187626819	C	G	187626819	3	3	6	1	0	0	0	0	1	0	0	0	5491	711	25	4	1780	4	FAM171B	2	187626819	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	104	187626819	55572554	121	834										
ABI2	10152	broad.mit.edu	37	chr2	204291976	204291976	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggagccattatttatgtcatCaagaagaatgacgatggttg	11	5	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:204291976C>G	uc002vaa.2	+	11	1678	c.1443C>G	c.(1441-1443)ATC>ATG	p.I481M	ABI2_uc002uzz.2_Missense_Mutation_p.I443M|ABI2_uc010zih.1_Missense_Mutation_p.I129M|ABI2_uc010zii.1_Missense_Mutation_p.I475M|ABI2_uc010zij.1_Missense_Mutation_p.I358M|ABI2_uc002vab.2_Missense_Mutation_p.I369M|ABI2_uc010zik.1_Missense_Mutation_p.I206M|ABI2_uc010zil.1_Missense_Mutation_p.I345M|ABI2_uc010zim.1_Missense_Mutation_p.I294M|ABI2_uc002vac.2_Missense_Mutation_p.I267M|ABI2_uc010zin.1_Missense_Mutation_p.I158M	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	481	SH3.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						TTTATGTCATCAAGAAGAATG	0.393													0	0	0	0.010504	0	18	65										G	204291976	C	G	204291976	3	3	6	1	0	0	0	0	1	0	0	0	89	816	29	1	1367	1	ABI2	2	204291976	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	16665157	204291976	38907397	122	835										
IDH1	3417	broad.mit.edu	37	chr2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttgatccccataagcatgaCgacctatgatgataggtttt	8	9	0	4	rs121913500		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:209113112C>T	uc002vcs.2	-	4	641	c.395G>A	c.(394-396)CGT>CAT	p.R132H	IDH1_uc002vct.2_Missense_Mutation_p.R132H|IDH1_uc002vcu.2_Missense_Mutation_p.R132H	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393			Mis		gliobastoma 								0	0	0	0.003271	0	34	71										T	209113112	C	T	209113112	3	4	6	1	0	0	0	0	1	0	0	0	7494	536	19	2	877	2	IDH1	2	209113112	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4821136	209113112	34086261	123	836										
MAP2	4133	broad.mit.edu	37	chr2	210557605	210557605	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttgccagcctggaagacatGaaacagaagacagaaccaag	11	9	0	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:210557605G>A	uc002vde.1	+	7	959	c.711G>A	c.(709-711)ATG>ATA	p.M237I	MAP2_uc002vdc.1_Missense_Mutation_p.M237I|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.M233I	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	237					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TGGAAGACATGAAACAGAAGA	0.458													0	0	0	0.004656	0	23	105										A	210557605	G	A	210557605	3	1	6	1	0	0	0	0	1	0	0	0	9235	1290	45	1	725	1	MAP2	2	210557605	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1444493	210557605	32641768	124	837										
TNS1	7145	broad.mit.edu	37	chr2	218712319	218712319	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgaagtcgcttcctttggtGagagcagaggctgagcagtg	15	8	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:218712319G>A	uc002vgt.2	-	17	2944	c.2546C>T	c.(2545-2547)TCA>TTA	p.S849L	TNS1_uc002vgr.2_Missense_Mutation_p.S849L|TNS1_uc002vgs.2_Missense_Mutation_p.S849L|TNS1_uc010zjv.1_Missense_Mutation_p.S849L|TNS1_uc010fvj.1_Missense_Mutation_p.S917L|TNS1_uc010fvk.1_Missense_Mutation_p.S974L|TNS1_uc010fvi.1_Missense_Mutation_p.S536L	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	849						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TTCCTTTGGTGAGAGCAGAGG	0.602													0	0	0	0.004878	0	39	97										A	218712319	G	A	218712319	3	1	6	1	0	0	0	0	1	0	0	0	16340	1294	45	1	2729	1	TNS1	2	218712319	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8154714	218712319	24487054	125	838										
SGPP2	130367	broad.mit.edu	37	chr2	223389719	223389719	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttttccaccttggtgtgtctCagcaggctctacactgggat	10	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:223389719C>T	uc010zlo.1	+	4	615	c.615C>T	c.(613-615)CTC>CTT	p.L205L	SGPP2_uc010zlp.1_Silent_p.L77L	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	205	Helical; (Potential).				sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TGGTGTGTCTCAGCAGGCTCT	0.473													0	0	0	0.004007	0	15	64										T	223389719	C	T	223389719	2	4	6	1	0	0	0	0	0	0	0	1	14220	813	29	1		1	SGPP2	2	223389719	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4677400	223389719	19809654	126	839										
IRS1	3667	broad.mit.edu	37	chr2	227662879	227662879	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagttcagcttcacgaagctGatggtcttgctggtcaggca	13	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:227662879G>A	uc002voh.3	-	1	628	c.576C>T	c.(574-576)ATC>ATT	p.I192I		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	192	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TCACGAAGCTGATGGTCTTGC	0.552											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	17	72										A	227662879	G	A	227662879	2	1	6	1	0	0	0	0	0	0	0	1	7840	1280	45	1		1	IRS1	2	227662879	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4273160	227662879	15536494	127	840										
IRS1	3667	broad.mit.edu	37	chr2	227663125	227663125	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcacggttgtgcagctgtagGagagcctggtaccagctgtc	15	10	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:227663125G>C	uc002voh.3	-	1	382	c.330C>G	c.(328-330)CTC>CTG	p.L110L		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	110	PH.|Mediates interaction with PHIP (By similarity).				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GCAGCTGTAGGAGAGCCTGGT	0.672											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004656	0	26	131										C	227663125	G	C	227663125	2	2	6	1	0	0	0	0	0	0	0	1	7840	1161	41	1		1	IRS1	2	227663125	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	246	227663125	15536248	128	841										
COL4A4	1286	broad.mit.edu	37	chr2	227886844	227886844	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctggcgccccaggaaggcctGggattcggggacagtcatcc	15	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:227886844G>T	uc010zlt.1	-	43	4790	c.4136C>A	c.(4135-4137)CCA>CAA	p.P1379Q		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1379	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		AGGAAGGCCTGGGATTCGGGG	0.582													1	0	9.61239e-26	0.01441	1.00116e-25	76	297										T	227886844	G	T	227886844	3	4	6	1	0	0	0	0	1	0	0	0	3693	1348	47	4	956	4	COL4A4	2	227886844	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	223719	227886844	15312529	129	842										
COL4A3	1285	broad.mit.edu	37	chr2	228163449	228163449	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcatgtaataggcataaaagGagacaaagggtctatgggcc	12	6	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:228163449G>C	uc002vom.1	+	43	3965	c.3803G>C	c.(3802-3804)GGA>GCA	p.G1268A	COL4A3_uc002von.1_Missense_Mutation_p.G1268A|COL4A3_uc002voo.1_Missense_Mutation_p.G1268A|COL4A3_uc002vop.1_Missense_Mutation_p.G1268A|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1268	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCATAAAAGGAGACAAAGGG	0.522													0	0	0	0.014323	0	21	73										C	228163449	G	C	228163449	3	2	6	1	0	0	0	0	1	0	0	0	3691	1174	41	1	3973	1	COL4A3	2	228163449	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	276605	228163449	15035924	130	843										
TRIP12	9320	broad.mit.edu	37	chr2	230656622	230656622	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccaaataccagctctgcctaGaggattgctctcatcatctg	7	13	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:230656622G>A	uc002vpw.1	-	28	4259	c.4150C>T	c.(4150-4152)CTA>TTA	p.L1384L	TRIP12_uc002vpx.1_Silent_p.L1432L|TRIP12_uc002vpy.1_Silent_p.L1114L	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1384					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GCTCTGCCTAGAGGATTGCTC	0.378													0	0	0	0.01441	0	58	199										A	230656622	G	A	230656622	2	1	6	1	0	0	0	0	0	0	0	1	16553	933	33	1		1	TRIP12	2	230656622	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2493173	230656622	12542751	131	844										
ARMC9	80210	broad.mit.edu	37	chr2	232141419	232141419	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgatgttctgaaggaccctGactgcctgtctgactacacg	10	11	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:232141419G>A	uc002vrq.3	+	15	1517	c.1405G>A	c.(1405-1407)GAC>AAC	p.D469N	ARMC9_uc002vrp.3_Missense_Mutation_p.D469N|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	469							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GAAGGACCCTGACTGCCTGTC	0.557													0	0	0	0.01441	0	47	159										A	232141419	G	A	232141419	3	1	6	1	0	0	0	0	1	0	0	0	958	1290	45	1	1459	1	ARMC9	2	232141419	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1484797	232141419	11057954	132	845										
ARMC9	80210	broad.mit.edu	37	chr2	232141443	232141443	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcctgtctgactacacgctgGagtactcggtggctttgctc	12	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:232141443G>A	uc002vrq.3	+	15	1541	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K	ARMC9_uc002vrp.3_Missense_Mutation_p.E477K|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	477							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CTACACGCTGGAGTACTCGGT	0.567													0	0	0	0.00623	0	37	139										A	232141443	G	A	232141443	3	1	6	1	0	0	0	0	1	0	0	0	958	1175	41	1	1483	1	ARMC9	2	232141443	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	24	232141443	11057930	133	846										
HDAC4	9759	broad.mit.edu	37	chr2	240061422	240061422	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgggcgcgataccgttctcCgcgctgacgctcccggagct	14	16	1	1	rs138989369	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:240061422C>T	uc002vyk.3	-	9	1728	c.936G>A	c.(934-936)GCG>GCA	p.A312A	HDAC4_uc010fyz.1_Silent_p.A307A|HDAC4_uc010zoa.1_Silent_p.A307A|HDAC4_uc010fza.2_Silent_p.A312A|HDAC4_uc010fyy.2_Silent_p.A264A|HDAC4_uc010znz.1_Silent_p.A195A|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	312	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TACCGTTCTCCGCGCTGACGC	0.662													0	0	0	0.010771	0	40	121										T	240061422	C	T	240061422	2	4	6	1	0	0	0	0	0	0	0	1	7009	639	23	2		2	HDAC4	2	240061422	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7919979	240061422	3137951	134	847										
MTERFD2	130916	broad.mit.edu	37	chr2	242039257	242039257	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttctccaagatgaggagtcTgcctagccatacaggcccag	11	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:242039257T>C	uc002wan.1	-	1	654	c.161A>G	c.(160-162)CAG>CGG	p.Q54R	MTERFD2_uc010zoj.1_Intron|MTERFD2_uc010zok.1_Missense_Mutation_p.Q25R	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	25										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		ATGAGGAGTCTGCCTAGCCAT	0.498													0	0	0	0.001855	0	12	26										C	242039257	T	C	242039257	3	2	6	1	0	0	0	0	1	0	0	0	9920	1580	55	5	1083	5	MTERFD2	2	242039257	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	1977835	242039257	1160116	135	848										
D2HGDH	728294	broad.mit.edu	37	chr2	242707248	242707248	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagcgtcagcgcggagcacgGagtgggcttcaggaagaggg	19	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr2:242707248G>C	uc002wce.1	+	10	1603	c.1430G>C	c.(1429-1431)GGA>GCA	p.G477A	D2HGDH_uc010fzq.1_Missense_Mutation_p.G343A|D2HGDH_uc002wcg.1_RNA|D2HGDH_uc002wch.2_RNA|D2HGDH_uc002wci.2_Missense_Mutation_p.G176A	NM_152783	NP_689996	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase precursor	477					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCGGAGCACGGAGTGGGCTTC	0.701													0	0	0	0.001168	0	5	16										C	242707248	G	C	242707248	3	2	6	1	0	0	0	0	1	0	0	0	4213	1174	41	1	1464	1	D2HGDH	2	242707248	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	667991	242707248	492125	136	849										
FANCD2	2177	broad.mit.edu	37	chr3	10089620	10089620	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggttcttaaggatatgtgttCatccattctgtcgctggctc	10	9	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:10089620C>T	uc003buw.2	+	16	1376	c.1298C>T	c.(1297-1299)TCA>TTA	p.S433L	FANCD2_uc003bux.1_Missense_Mutation_p.S433L|FANCD2_uc003buy.1_Missense_Mutation_p.S433L|FANCD2_uc010hcw.1_5'Flank	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	433					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GATATGTGTTCATCCATTCTG	0.393			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	51	283										T	10089620	C	T	10089620	3	4	6	1	0	0	0	0	1	0	0	0	5665	838	29	1	1356	1	FANCD2	3	10089620	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		10089620	187932810	137	850										
FANCD2	2177	broad.mit.edu	37	chr3	10091133	10091133	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atactgccttagatgtccttCtagagttggtagtgttaaac	9	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:10091133C>G	uc003buw.2	+	17	1567	c.1489C>G	c.(1489-1491)CTA>GTA	p.L497V	FANCD2_uc003bux.1_Missense_Mutation_p.L497V|FANCD2_uc003buy.1_Missense_Mutation_p.L497V|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	497					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGATGTCCTTCTAGAGTTGGT	0.398			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	70	254										G	10091133	C	G	10091133	3	3	6	1	0	0	0	0	1	0	0	0	5665	912	32	1	1551	1	FANCD2	3	10091133	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1513	10091133	187931297	138	851										
NUP210	23225	broad.mit.edu	37	chr3	13393439	13393439	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acatctgcggtgctggtgttGaggaagaagtaacctgagcc	14	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:13393439G>C	uc003bxv.1	-	20	2858	c.2775C>G	c.(2773-2775)CTC>CTG	p.L925L	NUP210_uc003bxw.2_Silent_p.L101L|NUP210_uc003bxx.2_Silent_p.L597L	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	925	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TGCTGGTGTTGAGGAAGAAGT	0.617													0	0	0	0.008871	0	20	72										C	13393439	G	C	13393439	2	2	6	1	0	0	0	0	0	0	0	1	10760	1277	45	1		1	NUP210	3	13393439	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3302306	13393439	184628991	139	852										
TBC1D5	9779	broad.mit.edu	37	chr3	17300041	17300041	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcctcgtgctttgtaataatCtaaatttggatggaattgat	8	5	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:17300041C>G	uc003cbf.2	-	16	2953	c.1288G>C	c.(1288-1290)GAT>CAT	p.D430H	TBC1D5_uc010heu.2_Missense_Mutation_p.D17H|TBC1D5_uc010hev.2_Missense_Mutation_p.D430H|TBC1D5_uc003cbe.2_Missense_Mutation_p.D430H|TBC1D5_uc010hew.1_Missense_Mutation_p.D382H	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	430						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						TTGTAATAATCTAAATTTGGA	0.308													0	0	0	0.01441	0	62	208										G	17300041	C	G	17300041	3	3	6	1	0	0	0	0	1	0	0	0	15620	913	32	1	1197	1	TBC1D5	3	17300041	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3906602	17300041	180722389	140	853										
KAT2B	8850	broad.mit.edu	37	chr3	20082225	20082225	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagcgcaactacgctccgctCcgcgggccaagaaactggag	12	14	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:20082225C>G	uc003cbq.2	+	1	702	c.256C>G	c.(256-258)CCG>GCG	p.P86A		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	86					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACGCTCCGCTCCGCGGGCCAA	0.706													0	0	0	0.000602	0	4	27										G	20082225	C	G	20082225	3	3	6	1	0	0	0	0	1	0	0	0	7982	855	30	1	258	1	KAT2B	3	20082225	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2782184	20082225	177940205	141	854										
AZI2	64343	broad.mit.edu	37	chr3	28381983	28381983	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgatgtcttcatatgcagtGacaagagcaaaatgggaagc	11	6	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:28381983G>A	uc003ceb.2	-	2	658	c.126C>T	c.(124-126)GTC>GTT	p.V42V	AZI2_uc003cec.2_5'UTR|AZI2_uc003ced.2_Silent_p.V42V|AZI2_uc003cee.3_Silent_p.V42V|AZI2_uc003ceg.2_Silent_p.V42V|AZI2_uc011axd.1_Silent_p.V42V|AZI2_uc003cef.2_Silent_p.V42V	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	42	Potential.					mitochondrion|plasma membrane				ovary(2)	2						CATATGCAGTGACAAGAGCAA	0.333													0	0	0	0.005443	0	29	95										A	28381983	G	A	28381983	2	1	6	1	0	0	0	0	0	0	0	1	1241	1277	45	1		1	AZI2	3	28381983	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8299758	28381983	169640447	142	855										
UBP1	7342	broad.mit.edu	37	chr3	33450953	33450953	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtcttaccttaaaaactttGatttggcagctagctgagtg	9	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:33450953G>C	uc003cfq.3	-	6	1226	c.696C>G	c.(694-696)ATC>ATG	p.I232M	UBP1_uc003cfr.3_Missense_Mutation_p.I232M|UBP1_uc010hga.2_Missense_Mutation_p.I232M	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	232					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						TAAAAACTTTGATTTGGCAGC	0.418													0	0	0	0.011902	0	45	142										C	33450953	G	C	33450953	3	2	6	1	0	0	0	0	1	0	0	0	16892	1280	45	1	970	1	UBP1	3	33450953	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5068970	33450953	164571477	143	856										
UBP1	7342	broad.mit.edu	37	chr3	33458292	33458292	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaggcatatcacccattttCcgattatccagcatccgaat	5	13	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:33458292C>G	uc003cfq.3	-	3	830	c.300G>C	c.(298-300)CGG>CGC	p.R100R	UBP1_uc003cfr.3_Silent_p.R100R|UBP1_uc010hga.2_Silent_p.R100R	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	100					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						CACCCATTTTCCGATTATCCA	0.318													0	0	0	0.007291	0	27	79										G	33458292	C	G	33458292	2	3	6	1	0	0	0	0	0	0	0	1	16892	842	30	1		1	UBP1	3	33458292	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7339	33458292	164564138	144	857										
SCN11A	11280	broad.mit.edu	37	chr3	38921615	38921615	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggtgaacatcttcaaatatCtgaaatgaaaaagcatagcc	7	7	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:38921615C>G	uc011ays.1	-	19	3419	c.3220_splice	c.e19-1	p.I1074_splice	SCN11A_uc010hhn.1_Intron	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha						response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTCAAATATCTGAAATGAAA	0.318													0	0	0	0.004482	0	8	31										G	38921615	C	G	38921615	5	3	6	1	0	0	0	0	0	0	1	0	13913	927	32	1	2188	1	SCN11A	3	38921615	Splice_Site	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5463323	38921615	159100815	145	858										
CX3CR1	1524	broad.mit.edu	37	chr3	39307706	39307706	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agtgaatttgcacatggcatTgtggaggcccttttcattta	10	7	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:39307706T>A	uc003cjl.2	-	2	387	c.295A>T	c.(295-297)AAT>TAT	p.N99Y		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	99	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CACATGGCATTGTGGAGGCCC	0.463													0	0	0	0.007835	0	39	112										A	39307706	T	A	39307706	3	1	6	1	0	0	0	0	1	0	0	0	4075	1812	63	5	776	5	CX3CR1	3	39307706	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	386091	39307706	158714724	146	859										
ZNF620	253639	broad.mit.edu	37	chr3	40557421	40557421	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccaaagaaacagagtccttCagactgatggtggggggcct	13	9	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:40557421C>G	uc003ckk.2	+	5	485	c.336C>G	c.(334-336)TTC>TTG	p.F112L	ZNF620_uc003ckl.2_5'UTR	NM_175888	NP_787084	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CAGAGTCCTTCAGACTGATGG	0.463													0	0	0	0.003163	0	16	52										G	40557421	C	G	40557421	3	3	6	1	0	0	0	0	1	0	0	0	18041	825	29	1	350	1	ZNF620	3	40557421	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1249715	40557421	157465009	147	860										
NKTR	4820	broad.mit.edu	37	chr3	42672757	42672757	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgcaagcagaccatatgcaGatgtgcgagttattgactgt	11	8	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:42672757G>C	uc003clo.2	+	8	646	c.499G>C	c.(499-501)GAT>CAT	p.D167H	NKTR_uc003clm.1_5'UTR|NKTR_uc003clp.2_5'UTR|NKTR_uc011azp.1_Missense_Mutation_p.D57H|NKTR_uc003clq.1_Missense_Mutation_p.D57H|NKTR_uc003clr.1_5'UTR|NKTR_uc003cls.2_5'UTR	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	167	PPIase cyclophilin-type.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		ACCATATGCAGATGTGCGAGT	0.388													0	0	0	0.00499	0	17	50										C	42672757	G	C	42672757	3	2	6	1	0	0	0	0	1	0	0	0	10448	942	33	1	525	1	NKTR	3	42672757	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2115336	42672757	155349673	148	861										
KBTBD5	131377	broad.mit.edu	37	chr3	42730464	42730464	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctttggggccactgtccatGatggccgcattatcgtggca	12	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:42730464G>A	uc003clv.1	+	4	1625	c.1525G>A	c.(1525-1527)GAT>AAT	p.D509N		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	509	Kelch 3.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CACTGTCCATGATGGCCGCAT	0.557													0	0	0	0.014323	0	19	55										A	42730464	G	A	42730464	3	1	6	1	0	0	0	0	1	0	0	0	7996	1290	45	1	1539	1	KBTBD5	3	42730464	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	57707	42730464	155291966	149	862										
KIF15	56992	broad.mit.edu	37	chr3	44893313	44893313	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaagtgccctttacaacaaaGagatggaatgccttagaatg	9	7	0	2	rs77808243		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:44893313G>C	uc003cnx.3	+	33	3990	c.3841G>C	c.(3841-3843)GAG>CAG	p.E1281Q	KIF15_uc010hiq.2_Missense_Mutation_p.E1184Q|KIF15_uc010hir.2_Missense_Mutation_p.E329Q	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	1281	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TTACAACAAAGAGATGGAATG	0.373													0	0	0	0.013114	0	43	158										C	44893313	G	C	44893313	3	2	6	1	0	0	0	0	1	0	0	0	8277	943	33	1	3971	1	KIF15	3	44893313	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2162849	44893313	153129117	150	863										
FBXW12	285231	broad.mit.edu	37	chr3	48423544	48423544	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaggagctgctgtcacctgGaaaacacgtggcatgatcac	11	11	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:48423544G>T	uc003csr.2	+	10	1450	c.1264G>T	c.(1264-1266)GAA>TAA	p.E422*	FBXW12_uc010hjv.2_Nonsense_Mutation_p.E403*|FBXW12_uc003css.2_Nonsense_Mutation_p.E352*|FBXW12_uc010hjw.2_Nonsense_Mutation_p.E321*	NM_207102	NP_996985	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12 isoform	422											0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGTCACCTGGAAAACACGTG	0.428													1	0	9.31168e-06	0.001855	9.45431e-06	9	39										T	48423544	G	T	48423544	4	4	6	1	0	0	0	0	0	1	0	0	5765	1175	41	3	1335	3	FBXW12	3	48423544	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3530231	48423544	149598886	151	864										
COL7A1	1294	broad.mit.edu	37	chr3	48621376	48621376	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caatgccaccttcacctggtCcagggggaccctgggagaga	13	13	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:48621376C>T	uc003ctz.2	-	38	4236	c.4235G>A	c.(4234-4236)GGA>GAA	p.G1412E		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1412	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTCACCTGGTCCAGGGGGACC	0.652													0	0	0	0.004482	0	9	56										T	48621376	C	T	48621376	3	4	6	1	0	0	0	0	1	0	0	0	3704	855	30	1	4923	1	COL7A1	3	48621376	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	197832	48621376	149401054	152	865										
UQCRC1	7384	broad.mit.edu	37	chr3	48641043	48641043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggggccttgtaatgtgtgctGaggtactcggtcaagtctgc	15	8	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:48641043G>A	uc003cub.1	-	6	705	c.660C>T	c.(658-660)CTC>CTT	p.L220L	UQCRC1_uc003cua.1_Silent_p.L105L|UQCRC1_uc003cuc.1_Silent_p.L220L|UQCRC1_uc003cud.1_Silent_p.L220L	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	220					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	AATGTGTGCTGAGGTACTCGG	0.532													0	0	0	0.00308	0	8	45										A	48641043	G	A	48641043	2	1	6	1	0	0	0	0	0	0	0	1	17016	1277	45	1		1	UQCRC1	3	48641043	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	19667	48641043	149381387	153	866										
CELSR3	1951	broad.mit.edu	37	chr3	48684260	48684260	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccctaaggtgcggtaaacgaGgagaatgataatggagatcc	13	7	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:48684260G>A	uc003cul.2	-	21	7512	c.7231C>T	c.(7231-7233)CTC>TTC	p.L2411F	CELSR3_uc003cuf.1_Missense_Mutation_p.L2481F|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.L394F	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2411	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGGTAAACGAGGAGAATGATA	0.607													0	0	0	0.004007	0	15	42										A	48684260	G	A	48684260	3	1	6	1	0	0	0	0	1	0	0	0	3223	1000	35	2	2767	2	CELSR3	3	48684260	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	43217	48684260	149338170	154	867										
BSN	8927	broad.mit.edu	37	chr3	49690134	49690134	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggaggaggagctgcgggagGaagaggagctgcttcgtgag	21	5	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:49690134G>C	uc003cxe.3	+	5	3259	c.3145G>C	c.(3145-3147)GAA>CAA	p.E1049Q		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1049	Potential.				synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCTGCGGGAGGAAGAGGAGCT	0.652													0	0	0	0.00308	0	8	29										C	49690134	G	C	49690134	3	2	6	1	0	0	0	0	1	0	0	0	1530	1175	41	1	3163	1	BSN	3	49690134	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1005874	49690134	148332296	155	868										
CAMKV	79012	broad.mit.edu	37	chr3	49899235	49899235	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacactcacagctccaggaaGataaagtactccttgcgggt	9	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:49899235G>C	uc003cxt.1	-	4	484	c.291C>G	c.(289-291)ATC>ATG	p.I97M	CAMKV_uc011bcy.1_Missense_Mutation_p.I22M|CAMKV_uc003cxv.1_Missense_Mutation_p.I97M|CAMKV_uc003cxw.1_Translation_Start_Site|CAMKV_uc003cxx.1_Translation_Start_Site|CAMKV_uc003cxu.2_Missense_Mutation_p.I97M|CAMKV_uc011bcz.1_Missense_Mutation_p.I60M|CAMKV_uc011bda.1_Missense_Mutation_p.I97M|CAMKV_uc011bdb.1_RNA	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	97	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCTCCAGGAAGATAAAGTACT	0.582													0	0	0	0.003163	0	14	65										C	49899235	G	C	49899235	3	2	6	1	0	0	0	0	1	0	0	0	2608	932	33	1	1246	1	CAMKV	3	49899235	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	209101	49899235	148123195	156	869										
CYB561D2	11068	broad.mit.edu	37	chr3	50391174	50391174	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgcaagaggatccaaccatGagctcttcccagcctagggg	11	14	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:50391174G>C	uc003dak.2	+	3	1244	c.668G>C	c.(667-669)TGA>TCA	p.*223S	NPRL2_uc003dai.1_5'Flank|NPRL2_uc003daj.1_5'Flank|CYB561D2_uc003dal.2_Nonstop_Mutation_p.*223S|CYB561D2_uc003dam.2_Nonstop_Mutation_p.*223S	NM_007022	NP_008953	O14569	C56D2_HUMAN	cytochrome b-561 domain containing 2	223					electron transport chain|transport	integral to membrane	metal ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		ATCCAACCATGAGCTCTTCCC	0.557													0	0	0	0.00333	0	21	96										C	50391174	G	C	50391174	4	2	6	1	0	0	0	0	0	0	0	0	4121	1285	45	1	678	1	CYB561D2	3	50391174	Nonstop_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	491939	50391174	147631256	157	870										
RFT1	91869	broad.mit.edu	37	chr3	53157763	53157763	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agccacagcaggttgagggtCtggctccagtctcgctgggt	15	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:53157763C>T	uc003dgj.2	-	3	297	c.243G>A	c.(241-243)CAG>CAA	p.Q81Q	RFT1_uc003dgk.2_Intron	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	81					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GGTTGAGGGTCTGGCTCCAGT	0.542													0	0	0	0.013537	0	13	49										T	53157763	C	T	53157763	2	4	6	1	0	0	0	0	0	0	0	1	13257	912	32	1		1	RFT1	3	53157763	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2766589	53157763	144864667	158	871										
DCP1A	55802	broad.mit.edu	37	chr3	53326414	53326414	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agctcagggactggctggttCaggagtggagacctctgtct	15	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:53326414C>T	uc003dgs.3	-	7	1161	c.1068G>A	c.(1066-1068)CTG>CTA	p.L356L	DCP1A_uc003dgt.3_RNA	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A	356					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		CTGGCTGGTTCAGGAGTGGAG	0.582													0	0	0	0.004656	0	25	66										T	53326414	C	T	53326414	2	4	6	1	0	0	0	0	0	0	0	1	4298	813	29	1		1	DCP1A	3	53326414	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	168651	53326414	144696016	159	872										
CCDC66	285331	broad.mit.edu	37	chr3	56647736	56647736	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caggaacgtgaagagatgcaGaaacagtatgaagaagacat	12	5	0	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:56647736G>A	uc003dhz.2	+	11	1611	c.1524G>A	c.(1522-1524)CAG>CAA	p.Q508Q	CCDC66_uc003dhy.2_Silent_p.Q144Q|CCDC66_uc003dhu.2_Silent_p.Q474Q|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dia.2_5'Flank	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	508	Potential.									breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		AAGAGATGCAGAAACAGTATG	0.343													0	0	0	0.00632	0	27	84										A	56647736	G	A	56647736	2	1	6	1	0	0	0	0	0	0	0	1	2838	933	33	1		1	CCDC66	3	56647736	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3321322	56647736	141374694	160	873										
GBE1	2632	broad.mit.edu	37	chr3	81586104	81586104	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tatctttcttccaatctattCatatccctgtcaaaattatt	1	10	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:81586104C>T	uc003dqg.2	-	14	2044	c.1761G>A	c.(1759-1761)ATG>ATA	p.M587I	GBE1_uc011bgm.1_Missense_Mutation_p.M546I	NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	587					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CCAATCTATTCATATCCCTGT	0.413									Glycogen_Storage_Disease_type_IV				0	0	0	0.007413	0	19	75										T	81586104	C	T	81586104	3	4	6	1	0	0	0	0	1	0	0	0	6270	826	29	1	363	1	GBE1	3	81586104	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	24938368	81586104	116436326	161	874										
C3orf26	84319	broad.mit.edu	37	chr3	99865849	99865849	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgaaggagaaggagacacaGaagtgatgcagcaggagaca	16	5	0	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:99865849G>A	uc003dtl.2	+	2	240	c.97G>A	c.(97-99)GAA>AAA	p.E33K		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	33							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						AGGAGACACAGAAGTGATGCA	0.433													0	0	0	0.010729	0	9	49										A	99865849	G	A	99865849	3	1	6	1	0	0	0	0	1	0	0	0	2218	943	33	1	117	1	C3orf26	3	99865849	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	18279745	99865849	98156581	162	875										
ZBTB11	27107	broad.mit.edu	37	chr3	101390113	101390113	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attaacaaagtaacatcacaGaactggttggaaagtctctg	8	7	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:101390113G>A	uc003dve.3	-	3	869	c.639C>T	c.(637-639)TTC>TTT	p.F213F	ZBTB11_uc003dvf.2_3'UTR	NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TAACATCACAGAACTGGTTGG	0.373													0	0	0	0.003271	0	34	211										A	101390113	G	A	101390113	2	1	6	1	0	0	0	0	0	0	0	1	17521	933	33	1		1	ZBTB11	3	101390113	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1524264	101390113	96632317	163	876										
CBLB	868	broad.mit.edu	37	chr3	105438984	105438984	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcatgccaaaggggtcaatGatgctgcaacacctggagcc	13	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:105438984G>A	uc003dwc.2	-	10	1636	c.1314C>T	c.(1312-1314)ATC>ATT	p.I438I	CBLB_uc011bhi.1_Silent_p.I460I|CBLB_uc003dwd.1_Silent_p.I438I|CBLB_uc003dwe.1_Silent_p.I438I|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	438					cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AGGGGTCAATGATGCTGCAAC	0.498			Mis S		AML								0	0	0	0.004007	0	16	87										A	105438984	G	A	105438984	2	1	6	1	0	0	0	0	0	0	0	1	2701	1280	45	1		1	CBLB	3	105438984	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4048871	105438984	92583446	164	877										
ARHGAP31	57514	broad.mit.edu	37	chr3	119101938	119101938	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttccacacggtaggtctaaaGaaattgaagccactggttgc	10	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:119101938G>C	uc003ecj.3	+	6	1079	c.547G>C	c.(547-549)GAA>CAA	p.E183Q		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	183	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						TAGGTCTAAAGAAATTGAAGC	0.463													0	0	0	0.00278	0	22	145										C	119101938	G	C	119101938	3	2	6	1	0	0	0	0	1	0	0	0	880	943	33	1	569	1	ARHGAP31	3	119101938	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	13662954	119101938	78920492	165	878										
GOLGB1	2804	broad.mit.edu	37	chr3	121400701	121400701	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tattgctgctgcagattcttCaattccttcagctttaacca	5	11	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:121400701C>G	uc003eei.3	-	15	8817	c.8691G>C	c.(8689-8691)TTG>TTC	p.L2897F	GOLGB1_uc010hrc.2_Missense_Mutation_p.L2902F|GOLGB1_uc003eej.3_Missense_Mutation_p.L2863F	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2897	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		GCAGATTCTTCAATTCCTTCA	0.368													0	0	0	0.006122	0	19	148										G	121400701	C	G	121400701	3	3	6	1	0	0	0	0	1	0	0	0	6565	825	29	1	1120	1	GOLGB1	3	121400701	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2298763	121400701	76621729	166	879										
GOLGB1	2804	broad.mit.edu	37	chr3	121417101	121417101	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	catgctaagttccttcacctGagagagaagctggtctcttt	9	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:121417101G>T	uc003eei.3	-	13	2380	c.2254C>A	c.(2254-2256)CAG>AAG	p.Q752K	GOLGB1_uc010hrc.2_Missense_Mutation_p.Q757K|GOLGB1_uc003eej.3_Missense_Mutation_p.Q718K|GOLGB1_uc011bjm.1_Missense_Mutation_p.Q638K|GOLGB1_uc010hrd.1_Missense_Mutation_p.Q716K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	752	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCCTTCACCTGAGAGAGAAGC	0.418													1	0	1.30091e-30	0.006999	1.35951e-30	41	217										T	121417101	G	T	121417101	3	4	6	1	0	0	0	0	1	0	0	0	6565	1299	45	3	7565	3	GOLGB1	3	121417101	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	16400	121417101	76605329	167	880										
KPNA1	3836	broad.mit.edu	37	chr3	122215299	122215299	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttacctgctcttctcttttCtgctttcgtaactgcagtcc	5	13	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:122215299C>G	uc003efd.1	-	2	150	c.114G>C	c.(112-114)CAG>CAC	p.Q38H	KPNA1_uc011bjr.1_5'UTR|KPNA1_uc010hrh.2_5'UTR|KPNA1_uc003efe.2_Missense_Mutation_p.Q38H	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	38	IBB.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		CTTCTCTTTTCTGCTTTCGTA	0.373													0	0	0	0.005443	0	26	183										G	122215299	C	G	122215299	3	3	6	1	0	0	0	0	1	0	0	0	8429	912	32	1	1554	1	KPNA1	3	122215299	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	798198	122215299	75807131	168	881										
PARP9	83666	broad.mit.edu	37	chr3	122255822	122255822	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttttcaaactgtttcttttGatctagaagctcttgagttg	7	6	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:122255822G>C	uc010hri.2	-	9	2114	c.1969C>G	c.(1969-1971)CAA>GAA	p.Q657E	PARP9_uc003eff.3_Missense_Mutation_p.Q622E|PARP9_uc011bjs.1_Missense_Mutation_p.Q622E|PARP9_uc003efg.2_Missense_Mutation_p.Q202E|PARP9_uc003efi.2_Missense_Mutation_p.Q622E|PARP9_uc003efh.2_Missense_Mutation_p.Q657E|PARP9_uc003efj.2_Missense_Mutation_p.Q622E	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	657	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TGTTTCTTTTGATCTAGAAGC	0.353													0	0	0	0.01441	0	50	290										C	122255822	G	C	122255822	3	2	6	1	0	0	0	0	1	0	0	0	11466	1299	45	1	660	1	PARP9	3	122255822	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	40523	122255822	75766608	169	882										
PARP14	54625	broad.mit.edu	37	chr3	122447406	122447406	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgtggcattttatgactacCaagcatacccagagtacctt	7	10	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:122447406C>G	uc003efq.3	+	17	5427	c.5368C>G	c.(5368-5370)CAA>GAA	p.Q1790E	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.Q1507E	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1790	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		TTATGACTACCAAGCATACCC	0.368													0	0	0	0.010771	0	43	256										G	122447406	C	G	122447406	3	3	6	1	0	0	0	0	1	0	0	0	11458	595	21	4	5434	4	PARP14	3	122447406	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	191584	122447406	75575024	170	883										
PDIA5	10954	broad.mit.edu	37	chr3	122865043	122865043	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacgttgaagtattttaagaAtggagagaaatacgcagtgc	11	4	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:122865043A>T	uc003egc.1	+	13	1135	c.1079A>T	c.(1078-1080)AAT>ATT	p.N360I	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	360	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		TATTTTAAGAATGGAGAGAAA	0.468													0	0	0	0.00623	0	41	303										T	122865043	A	T	122865043	3	4	6	1	0	0	0	0	1	0	0	0	11671	101	4	5	1129	5	PDIA5	3	122865043	Missense_Mutation	SNP	A	TCGA-BT-A0YX-01A-11D-A10S-08	417637	122865043	75157387	171	884										
ADCY5	111	broad.mit.edu	37	chr3	123051504	123051504	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gccaggctggtgaagccctcGatgtcagcaaacaggatgct	13	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:123051504G>C	uc003egh.1	-	4	1425	c.1425C>G	c.(1423-1425)ATC>ATG	p.I475M	ADCY5_uc003egg.1_Missense_Mutation_p.I108M|ADCY5_uc003egi.1_Missense_Mutation_p.I34M	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	475	Guanylate cyclase 1.|Cytoplasmic (Potential).	Magnesium 2; via carbonyl oxygen (By similarity).			activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGAAGCCCTCGATGTCAGCAA	0.448													0	0	0	0.001168	0	5	60										C	123051504	G	C	123051504	3	2	6	1	0	0	0	0	1	0	0	0	297	1048	37	1	2432	1	ADCY5	3	123051504	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	186461	123051504	74970926	172	885										
KALRN	8997	broad.mit.edu	37	chr3	123987680	123987680	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctccctggactacaaccatGaggagtggatcgaactgcgg	13	11	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:123987680G>C	uc003ehg.2	+	5	668	c.541G>C	c.(541-543)GAG>CAG	p.E181Q	KALRN_uc010hrv.1_Missense_Mutation_p.E181Q|KALRN_uc003ehf.1_Missense_Mutation_p.E181Q|KALRN_uc011bjy.1_Missense_Mutation_p.E181Q	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	181					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTACAACCATGAGGAGTGGAT	0.612													0	0	0	0.01441	0	63	88										C	123987680	G	C	123987680	3	2	6	1	0	0	0	0	1	0	0	0	7975	1291	45	1	559	1	KALRN	3	123987680	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	936176	123987680	74034750	173	886										
KALRN	8997	broad.mit.edu	37	chr3	123987800	123987800	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggagtttcctgtggatgtgGagggctctcggcggctcatt	16	8	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:123987800G>A	uc003ehg.2	+	5	788	c.661G>A	c.(661-663)GAG>AAG	p.E221K	KALRN_uc010hrv.1_Missense_Mutation_p.E221K|KALRN_uc003ehf.1_Missense_Mutation_p.E221K|KALRN_uc011bjy.1_Missense_Mutation_p.E221K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	221	Spectrin 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TGTGGATGTGGAGGGCTCTCG	0.627													0	0	0	0.007291	0	30	26										A	123987800	G	A	123987800	3	1	6	1	0	0	0	0	1	0	0	0	7975	1175	41	1	679	1	KALRN	3	123987800	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	120	123987800	74034630	174	887										
C3orf37	56941	broad.mit.edu	37	chr3	129020945	129020945	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaacaactcgcgaaacaacaCtcctgagtgtctggctcctg	9	13	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:129020945C>G	uc003elt.2	+	6	876	c.788C>G	c.(787-789)ACT>AGT	p.T263S	C3orf37_uc003elu.2_Missense_Mutation_p.T221S|C3orf37_uc003elv.2_Missense_Mutation_p.T263S|C3orf37_uc003elw.2_Missense_Mutation_p.T263S	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	263										ovary(1)	1						CGAAACAACACTCCTGAGTGT	0.483													0	0	0	0.003755	0	33	189										G	129020945	C	G	129020945	3	3	6	1	0	0	0	0	1	0	0	0	2227	565	20	4	806	4	C3orf37	3	129020945	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5033145	129020945	69001485	175	888										
C3orf37	56941	broad.mit.edu	37	chr3	129023525	129023525	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caaaaacacctcaaaaggaaGagtcagatgttccccagtgg	9	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:129023525G>C	uc003elt.2	+	7	1010	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	C3orf37_uc003elu.2_Missense_Mutation_p.E266Q|C3orf37_uc003elv.2_Missense_Mutation_p.E308Q|C3orf37_uc003elw.2_Missense_Mutation_p.E308Q	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	308										ovary(1)	1						TCAAAAGGAAGAGTCAGATGT	0.532													0	0	0	0.012213	0	32	135										C	129023525	G	C	129023525	3	2	6	1	0	0	0	0	1	0	0	0	2227	943	33	1	944	1	C3orf37	3	129023525	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2580	129023525	68998905	176	889										
PLXND1	23129	broad.mit.edu	37	chr3	129282030	129282030	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgtcgatggagcccttgttGatttgctgcttgatggcaca	13	9	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:129282030G>A	uc003emx.2	-	26	4675	c.4575C>T	c.(4573-4575)ATC>ATT	p.I1525I	PLXND1_uc011blb.1_Silent_p.I193I	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1525	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AGCCCTTGTTGATTTGCTGCT	0.617													0	0	0	0.013537	0	12	44										A	129282030	G	A	129282030	2	1	6	1	0	0	0	0	0	0	0	1	12127	1280	45	1		1	PLXND1	3	129282030	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	258505	129282030	68740400	177	890										
COL6A6	131873	broad.mit.edu	37	chr3	130290018	130290018	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagtcctcattgtgatcaccGatggggaatcccatgatgct	10	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:130290018G>A	uc010htl.2	+	6	2789	c.2758G>A	c.(2758-2760)GAT>AAT	p.D920N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	920	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TGTGATCACCGATGGGGAATC	0.557													0	0	0	0.003163	0	15	68										A	130290018	G	A	130290018	3	1	6	1	0	0	0	0	1	0	0	0	3703	1058	37	1	2780	1	COL6A6	3	130290018	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1007988	130290018	67732412	178	891										
PIK3R4	30849	broad.mit.edu	37	chr3	130464024	130464024	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaataactctctacagaaagGatctgggagggagcaatgcc	11	8	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:130464024G>C	uc003enj.2	-	2	620	c.39C>G	c.(37-39)ATC>ATG	p.I13M		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	13					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						CTACAGAAAGGATCTGGGAGG	0.398													0	0	0	0.00499	0	16	99										C	130464024	G	C	130464024	3	2	6	1	0	0	0	0	1	0	0	0	11921	1164	41	1	4113	1	PIK3R4	3	130464024	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	174006	130464024	67558406	179	892										
BFSP2	8419	broad.mit.edu	37	chr3	133185754	133185754	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtggagttacacaacacttCgtgccaagtccagagcctcc	10	13	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:133185754C>T	uc003epn.1	+	5	1112	c.974C>T	c.(973-975)TCG>TTG	p.S325L		NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	325	Rod.|Potential.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						CACAACACTTCGTGCCAAGTC	0.562													0	0	0	0.00278	0	23	143										T	133185754	C	T	133185754	3	4	6	1	0	0	0	0	1	0	0	0	1416	893	31	1	992	1	BFSP2	3	133185754	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2721730	133185754	64836676	180	893										
TXNDC6	347736	broad.mit.edu	37	chr3	138033219	138033219	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctttccatgggaaacacattCatcttcatcagaaagagcct	6	11	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:138033219C>T	uc003esg.2	-	6	443	c.415G>A	c.(415-417)GAA>AAA	p.E139K	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Missense_Mutation_p.E54K|TXNDC6_uc003ese.1_Missense_Mutation_p.E78K	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	139					cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						GAAACACATTCATCTTCATCA	0.358													0	0	0	0.010771	0	43	295										T	138033219	C	T	138033219	3	4	6	1	0	0	0	0	1	0	0	0	16797	835	29	1	583	1	TXNDC6	3	138033219	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4847465	138033219	59989211	181	894										
PIK3CB	5291	broad.mit.edu	37	chr3	138374293	138374293	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cactttagtagtccagctttCcctgagcgcctcatcaaatt	6	13	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:138374293C>T	uc011bmq.1	-	22	3151	c.3151G>A	c.(3151-3153)GAA>AAA	p.E1051K	PIK3CB_uc011bmn.1_Missense_Mutation_p.E563K|PIK3CB_uc011bmo.1_Missense_Mutation_p.E502K|PIK3CB_uc011bmp.1_Missense_Mutation_p.E638K|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1051	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GTCCAGCTTTCCCTGAGCGCC	0.423													0	0	0	0.01441	0	56	116										T	138374293	C	T	138374293	3	4	6	1	0	0	0	0	1	0	0	0	11914	864	30	1	63	1	PIK3CB	3	138374293	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	341074	138374293	59648137	182	895										
PIK3CB	5291	broad.mit.edu	37	chr3	138374305	138374305	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccagctttccctgagcgcctCatcaaatttttgcttaaact							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:138374305C>T	uc011bmq.1	-	22	3139	c.3139G>A	c.(3139-3141)GAG>AAG	p.E1047K	PIK3CB_uc011bmn.1_Missense_Mutation_p.E559K|PIK3CB_uc011bmo.1_Missense_Mutation_p.E498K|PIK3CB_uc011bmp.1_Missense_Mutation_p.E634K|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1047	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CTGAGCGCCTCATCAAATTTT	0.408													0	0	0	0.01441	0	56	117										T	138374305	C	T	138374305	3	4	6	1	0	0	0	0	1	0	0	0	11914	835	29	1	75	1	PIK3CB	3	138374305	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	12	138374305	59648125	183	896	2	2								
PIK3CB	5291	broad.mit.edu	37	chr3	138374308	138374308	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctttccctgagcgcctcatCaaatttttgcttaaactgtt							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:138374308C>T	uc011bmq.1	-	22	3136	c.3136G>A	c.(3136-3138)GAT>AAT	p.D1046N	PIK3CB_uc011bmn.1_Missense_Mutation_p.D558N|PIK3CB_uc011bmo.1_Missense_Mutation_p.D497N|PIK3CB_uc011bmp.1_Missense_Mutation_p.D633N|PIK3CB_uc003est.1_RNA	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	1046	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AGCGCCTCATCAAATTTTTGC	0.408													0	0	0	0.01441	0	56	118										T	138374308	C	T	138374308	3	4	6	1	0	0	0	0	1	0	0	0	11914	826	29	1	78	1	PIK3CB	3	138374308	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3	138374308	59648122	184	897	2	2								
PIK3CB	5291	broad.mit.edu	37	chr3	138433362	138433362	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagagggattaatagttttcGttgatttcttcgtttttact	8	4	1	2	rs143122477	by1000genomes	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:138433362G>A	uc011bmq.1	-	7	1250	c.1250C>T	c.(1249-1251)ACG>ATG	p.T417M	PIK3CB_uc011bmo.1_Translation_Start_Site|PIK3CB_uc011bmp.1_Missense_Mutation_p.T21M	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	417	Nuclear localization signal.|C2 PI3K-type.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AATAGTTTTCGTTGATTTCTT	0.318													0	0	0	0.01441	0	54	56										A	138433362	G	A	138433362	3	1	6	1	0	0	0	0	1	0	0	0	11914	1145	40	2	2024	2	PIK3CB	3	138433362	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	59054	138433362	59589068	185	898										
CLSTN2	64084	broad.mit.edu	37	chr3	140185546	140185546	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caggctgacacctttcgcccCgcggagttccactggaagct	11	15	0	1	rs139804872	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:140185546C>T	uc003etn.2	+	8	1507	c.1317C>T	c.(1315-1317)CCC>CCT	p.P439P	CLSTN2_uc003etm.2_Silent_p.P439P	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	439	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CCTTTCGCCCCGCGGAGTTCC	0.567										HNSCC(16;0.037)			0	0	0	0.004007	0	15	105										T	140185546	C	T	140185546	2	4	6	1	0	0	0	0	0	0	0	1	3562	639	23	2		2	CLSTN2	3	140185546	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1752184	140185546	57836884	186	899										
TRIM42	287015	broad.mit.edu	37	chr3	140401335	140401335	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccctgcgcactgggagcagcGatacccaggtggatgaagta	14	11	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:140401335G>C	uc003eto.1	+	2	564	c.373G>C	c.(373-375)GAT>CAT	p.D125H		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	125						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						TGGGAGCAGCGATACCCAGGT	0.557													0	0	0	0.010504	0	15	154										C	140401335	G	C	140401335	3	2	6	1	0	0	0	0	1	0	0	0	16514	1058	37	1	379	1	TRIM42	3	140401335	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	215789	140401335	57621095	187	900										
COMMD2	51122	broad.mit.edu	37	chr3	149459490	149459490	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggtttaatctgttgcctgaGacttctacttgcaagcttga	9	8	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:149459490G>A	uc003exk.2	-	5	465	c.418C>T	c.(418-420)CTC>TTC	p.L140F	COMMD2_uc003exj.1_5'Flank	NM_016094	NP_057178	Q86X83	COMD2_HUMAN	COMM domain containing 2	140	COMM.						protein binding				0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TGTTGCCTGAGACTTCTACTT	0.333													0	0	0	0.00278	0	23	214										A	149459490	G	A	149459490	3	1	6	1	0	0	0	0	1	0	0	0	3716	942	33	1	185	1	COMMD2	3	149459490	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	9058155	149459490	48562940	188	901										
PLCH1	23007	broad.mit.edu	37	chr3	155199659	155199659	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaagtgttctaccacaccctGattgtacttgagttttaaag	7	8	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:155199659G>C	uc011bok.1	-	23	4457	c.4180C>G	c.(4180-4182)CAG>GAG	p.Q1394E	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.Q1356E	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1394					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			ACCACACCCTGATTGTACTTG	0.403													0	0	0	0.013726	0	32	183										C	155199659	G	C	155199659	3	2	6	1	0	0	0	0	1	0	0	0	12037	1299	45	1	905	1	PLCH1	3	155199659	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5740169	155199659	42822771	189	902										
TRIM59	286827	broad.mit.edu	37	chr3	160156857	160156857	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ataaaagttaccagatgcctGaagaatgttttccaaacaat	6	7	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:160156857G>A	uc003fdm.2	-	3	310	c.115C>T	c.(115-117)CAG>TAG	p.Q39*	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	39	RING-type.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CCAGATGCCTGAAGAATGTTT	0.368													0	0	0	0.008871	0	18	131										A	160156857	G	A	160156857	4	1	6	1	0	0	0	0	0	1	0	0	16529	1299	45	1	1100	1	TRIM59	3	160156857	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4957198	160156857	37865573	190	903										
PDCD10	11235	broad.mit.edu	37	chr3	167414911	167414911	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagacctggattttctttttCagcctataataaagagaaaa	7	6	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:167414911C>G	uc003fex.2	-	5	552	c.154G>C	c.(154-156)GAA>CAA	p.E52Q	PDCD10_uc003fez.2_Missense_Mutation_p.E52Q|PDCD10_uc003fey.2_Missense_Mutation_p.E52Q	NM_007217	NP_009148	Q9BUL8	PDC10_HUMAN	programmed cell death 10	52					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			lung(1)|central_nervous_system(1)	2						TTTTCTTTTTCAGCCTATAAT	0.343									Familial_Cerebral_Cavernous_Angioma				0	0	0	0.006122	0	18	89										G	167414911	C	G	167414911	3	3	6	1	0	0	0	0	1	0	0	0	11616	835	29	1	504	1	PDCD10	3	167414911	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7258054	167414911	30607519	191	904										
GOLIM4	27333	broad.mit.edu	37	chr3	167759263	167759263	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctcaaattgtatacagtctCtattttagaaaaagaaggat	6	5	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:167759263C>G	uc003ffe.2	-	6	862	c.518_splice	c.e6-1	p.E173_splice	GOLIM4_uc011bpe.1_Splice_Site_p.E173_splice|GOLIM4_uc011bpf.1_Splice_Site_p.E173_splice|GOLIM4_uc011bpg.1_Splice_Site_p.E173_splice	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4						transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TATACAGTCTCTATTTTAGAA	0.318													0	0	0	0.010729	0	12	81										G	167759263	C	G	167759263	5	3	6	1	0	0	0	0	0	0	1	0	6566	927	32	1	1617	1	GOLIM4	3	167759263	Splice_Site	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	344352	167759263	30263167	192	905										
MECOM	2122	broad.mit.edu	37	chr3	168807914	168807915	+	Missense_Mutation	DNP	TC	TC	AT													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttccagtaatatcattgtctTcatcctcctcatctaacaac							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:168807914_168807915TC>AT	uc003ffi.3	-	14	2979_2980	c.2710_2711GA>AT	c.(2710-2712)GAA>ATA	p.E904I	MECOM_uc010hwk.1_Missense_Mutation_p.E918I|MECOM_uc003ffj.3_Missense_Mutation_p.E969I|MECOM_uc011bpi.1_Missense_Mutation_p.E896I|MECOM_uc003ffn.3_Missense_Mutation_p.E904I|MECOM_uc003ffk.2_Missense_Mutation_p.E895I|MECOM_uc003ffl.2_Missense_Mutation_p.E1055I|MECOM_uc011bpj.1_Missense_Mutation_p.E1092I|MECOM_uc011bpk.1_Missense_Mutation_p.E894I	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	904	Asp/Glu-rich (acidic).				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						ATCATTGTCTTCATCCTCCTCA	0.401													0	0	0	0.004672	0	160	226										AT	168807915	TC	AT	168807914	3	1	6	1	0	0	0	0	1	0	0	0	9422	1783	62	5	456	5	MECOM	3	168807914	Missense_Mutation	DNP	TC	TCGA-BT-A0YX-01A-11D-A10S-08	1048651	168807914	29214516	193	906										
ECE2	9718	broad.mit.edu	37	chr3	184009972	184009972	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgtgacttcctgcggcacttCggctgccctgtcggctcccc	11	18	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:184009972C>T	uc003fni.3	+	19	2636	c.2598C>T	c.(2596-2598)TTC>TTT	p.F866F	ECE2_uc003fnl.3_Silent_p.F794F|ECE2_uc003fnm.3_Silent_p.F748F|ECE2_uc003fnk.3_Silent_p.F719F	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	866	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCGGCACTTCGGCTGCCCTG	0.657													0	0	0	0.009535	0	29	154										T	184009972	C	T	184009972	2	4	6	1	0	0	0	0	0	0	0	1	4890	883	31	1		1	ECE2	3	184009972	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	15202058	184009972	14012458	194	907										
C3orf70	285382	broad.mit.edu	37	chr3	184870595	184870595	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaccccgctccgacgccggcGaggccgccgcactcatttcc	10	20	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:184870595G>A	uc003fpd.2	-	1	208	c.17C>T	c.(16-18)TCG>TTG	p.S6L		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	6											0						CGACGCCGGCGAGGCCGCCGC	0.716													0	0	0	0.004656	0	23	27										A	184870595	G	A	184870595	3	1	6	1	0	0	0	0	1	0	0	0	2242	1059	37	1	743	1	C3orf70	3	184870595	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	860623	184870595	13151835	195	908										
DNAJB11	51726	broad.mit.edu	37	chr3	186299204	186299204	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggcaggctcctggcaaacgGaagtgcaattgtcggcaaga	14	9	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:186299204G>A	uc003fqi.2	+	5	721	c.501G>A	c.(499-501)CGG>CGA	p.R167R		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	167					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		CTGGCAAACGGAAGTGCAATT	0.517													0	0	0	0.00333	0	24	158										A	186299204	G	A	186299204	2	1	6	1	0	0	0	0	0	0	0	1	4616	1161	41	1		1	DNAJB11	3	186299204	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1428609	186299204	11723226	196	909										
RFC4	5984	broad.mit.edu	37	chr3	186510677	186510677	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttaaagctgcctgagcagctGaggtcatagaatctgcttca	10	9	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:186510677G>A	uc003fqz.2	-	6	693	c.470C>T	c.(469-471)TCA>TTA	p.S157L	RFC4_uc011bsc.1_Missense_Mutation_p.S157L|RFC4_uc011bsd.1_Missense_Mutation_p.S157L	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	157					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		CTGAGCAGCTGAGGTCATAGA	0.428													0	0	0	0.013537	0	13	87										A	186510677	G	A	186510677	3	1	6	1	0	0	0	0	1	0	0	0	13247	1294	45	1	645	1	RFC4	3	186510677	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	211473	186510677	11511753	197	910										
RFC4	5984	broad.mit.edu	37	chr3	186512523	186512523	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacttgtattccacgttcatCagatgcatttaactcaagaa	5	9	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:186512523C>T	uc003fqz.2	-	5	557	c.334G>A	c.(334-336)GAT>AAT	p.D112N	RFC4_uc011bsc.1_Missense_Mutation_p.D112N|RFC4_uc011bsd.1_Missense_Mutation_p.D112N	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	112					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		CCACGTTCATCAGATGCATTT	0.368													0	0	0	0.00499	0	16	101										T	186512523	C	T	186512523	3	4	6	1	0	0	0	0	1	0	0	0	13247	826	29	1	785	1	RFC4	3	186512523	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1846	186512523	11509907	198	911										
TPRG1	285386	broad.mit.edu	37	chr3	188925327	188925327	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caagtgtgaccgaatcaactCtttaccccaatccttatcat	4	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:188925327C>G	uc003frv.1	+	7	1381	c.154C>G	c.(154-156)CTT>GTT	p.L52V	TPRG1_uc003frw.1_Missense_Mutation_p.L52V	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	52											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		CGAATCAACTCTTTACCCCAA	0.438													0	0	0	0.01441	0	48	185										G	188925327	C	G	188925327	3	3	6	1	0	0	0	0	1	0	0	0	16415	913	32	1	156	1	TPRG1	3	188925327	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2412804	188925327	9097103	199	912										
OPA1	4976	broad.mit.edu	37	chr3	193353228	193353228	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgaagtatcagagaatcttgGaacgattagaaaaggagaac	11	4	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:193353228G>A	uc003ftm.2	+	7	934	c.700G>A	c.(700-702)GAA>AAA	p.E234K	OPA1_uc003ftg.2_Missense_Mutation_p.E289K|OPA1_uc003fth.2_Missense_Mutation_p.E253K|OPA1_uc003fti.2_Missense_Mutation_p.E271K|OPA1_uc003ftj.2_Missense_Mutation_p.E252K|OPA1_uc003ftk.2_Missense_Mutation_p.E235K|OPA1_uc003ftl.2_Missense_Mutation_p.E216K|OPA1_uc003ftn.2_Missense_Mutation_p.E198K	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	234	Mitochondrial intermembrane (By similarity).|Potential.				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		GAGAATCTTGGAACGATTAGA	0.289													0	0	0	0.007413	0	18	120										A	193353228	G	A	193353228	3	1	6	1	0	0	0	0	1	0	0	0	10871	1175	41	1	899	1	OPA1	3	193353228	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4427901	193353228	4669202	200	913										
OPA1	4976	broad.mit.edu	37	chr3	193364936	193364936	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcttttggaaaatggtacgaGagtctgttgaacaacaggct	12	6	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:193364936G>C	uc003ftm.2	+	17	1906	c.1672G>C	c.(1672-1674)GAG>CAG	p.E558Q	OPA1_uc003ftg.2_Missense_Mutation_p.E613Q|OPA1_uc003fth.2_Missense_Mutation_p.E577Q|OPA1_uc003fti.2_Missense_Mutation_p.E595Q|OPA1_uc003ftj.2_Missense_Mutation_p.E576Q|OPA1_uc003ftk.2_Missense_Mutation_p.E559Q|OPA1_uc003ftl.2_Missense_Mutation_p.E540Q|OPA1_uc003ftn.2_Missense_Mutation_p.E522Q	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	558	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		AATGGTACGAGAGTCTGTTGA	0.358													0	0	0	0.000602	0	4	63										C	193364936	G	C	193364936	3	2	6	1	0	0	0	0	1	0	0	0	10871	943	33	1	1911	1	OPA1	3	193364936	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11708	193364936	4657494	201	914										
DLG1	1739	broad.mit.edu	37	chr3	196778504	196778504	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggctctctcaaatgtttttCtggcttgttcttctgttaga	8	8	5	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr3:196778504C>T	uc003fxo.3	-	25	2742	c.2552G>A	c.(2551-2553)AGA>AAA	p.R851K	DLG1_uc011bub.1_Missense_Mutation_p.R747K|DLG1_uc011buc.1_Missense_Mutation_p.R735K|DLG1_uc011bud.1_Missense_Mutation_p.R534K|DLG1_uc003fxn.3_Missense_Mutation_p.R873K|DLG1_uc011bue.1_Missense_Mutation_p.R839K|DLG1_uc010ial.2_Missense_Mutation_p.R851K	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	851	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		AAATGTTTTTCTGGCTTGTTC	0.328													0	0	0	0.00245	0	13	137										T	196778504	C	T	196778504	3	4	6	1	0	0	0	0	1	0	0	0	4554	913	32	1	170	1	DLG1	3	196778504	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3413568	196778504	1243926	202	915										
HAUS3	79441	broad.mit.edu	37	chr4	2233842	2233842	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcagtgaggagatgatttaGcttattcagttgagattcaa	10	4	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:2233842G>C	uc003ges.1	-	5	1854	c.1624C>G	c.(1624-1626)CTA>GTA	p.L542V	POLN_uc003ger.2_5'Flank|POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Intron|HAUS3_uc003get.1_Missense_Mutation_p.L542V	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	542					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						AGATGATTTAGCTTATTCAGT	0.264													0	0	0	0.013537	0	10	60										C	2233842	G	C	2233842	3	2	6	1	0	0	0	0	1	0	0	0	6967	962	34	4	191	4	HAUS3	4	2233842	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		2233842	188920434	203	916										
HTT	3064	broad.mit.edu	37	chr4	3208288	3208288	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatcacattcaagatctgatCagcctttcccacgagcctcc	5	15	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:3208288C>T	uc011bvq.1	+	44	5935	c.5790C>T	c.(5788-5790)ATC>ATT	p.I1930I		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1928					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		AAGATCTGATCAGCCTTTCCC	0.473													0	0	0	0.00278	0	25	112										T	3208288	C	T	3208288	2	4	6	1	0	0	0	0	0	0	0	1	7457	816	29	1		1	HTT	4	3208288	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	974446	3208288	187945988	204	917										
MAN2B2	23324	broad.mit.edu	37	chr4	6606942	6606942	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagcacccttcaatttggccGcaggctgaggagacgcacca	12	13	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:6606942G>A	uc003gjf.1	+	11	1736	c.1700G>A	c.(1699-1701)CGC>CAC	p.R567H	MAN2B2_uc003gje.1_Missense_Mutation_p.R567H|MAN2B2_uc011bwf.1_Missense_Mutation_p.R516H	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	567					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						CAATTTGGCCGCAGGCTGAGG	0.617													0	0	0	0.014323	0	14	35										A	6606942	G	A	6606942	3	1	6	1	0	0	0	0	1	0	0	0	9217	1087	38	2	1742	2	MAN2B2	4	6606942	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3398654	6606942	184547334	205	918										
CC2D2A	57545	broad.mit.edu	37	chr4	15529226	15529226	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccaagctggcccagttatatGaccagtaccttgcaagacac	8	13	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:15529226G>A	uc010idv.2	+	13	1551	c.1306G>A	c.(1306-1308)GAC>AAC	p.D436N	CC2D2A_uc003gnx.2_Missense_Mutation_p.D387N|CC2D2A_uc003gnv.2_Missense_Mutation_p.D436N	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	436					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						CCAGTTATATGACCAGTACCT	0.408													0	0	0	0.001984	0	6	31										A	15529226	G	A	15529226	3	1	6	1	0	0	0	0	1	0	0	0	2728	1290	45	1	1551	1	CC2D2A	4	15529226	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8922284	15529226	175625050	206	919										
PCDH7	5099	broad.mit.edu	37	chr4	30723906	30723906	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgacggcggcgacccgcctCgctcctcgcaggccatccta	12	19	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:30723906C>T	uc003gsk.1	+	1	1870	c.862C>T	c.(862-864)CGC>TGC	p.R288C	PCDH7_uc011bxw.1_Intron|PCDH7_uc011bxx.1_Missense_Mutation_p.R288C	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	288	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CGACCCGCCTCGCTCCTCGCA	0.672													0	0	0	0.004672	0	3	5										T	30723906	C	T	30723906	3	4	6	1	0	0	0	0	1	0	0	0	11516	884	31	1	864	1	PCDH7	4	30723906	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	15194680	30723906	160430370	207	920										
GABRG1	2565	broad.mit.edu	37	chr4	46060556	46060556	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taaccctacaaatgcaaactGatataatctccagtatttag	4	9	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:46060556G>C	uc003gxb.2	-	6	861	c.709C>G	c.(709-711)CAG>GAG	p.Q237E		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	237	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AATGCAAACTGATATAATCTC	0.353													0	0	0	0.00499	0	16	74										C	46060556	G	C	46060556	3	2	6	1	0	0	0	0	1	0	0	0	6171	1299	45	1	704	1	GABRG1	4	46060556	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	15336650	46060556	145093720	208	921										
GABRA4	2557	broad.mit.edu	37	chr4	46967025	46967025	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgcttctctctctgcactgGagcagcgggaacttcctgag	11	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:46967025G>C	uc003gxg.2	-	8	1235	c.1096C>G	c.(1096-1098)CCA>GCA	p.P366A		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	366	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTCTGCACTGGAGCAGCGGGA	0.433													0	0	0	0.00278	0	20	83										C	46967025	G	C	46967025	3	2	6	1	0	0	0	0	1	0	0	0	6163	1174	41	1	576	1	GABRA4	4	46967025	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	906469	46967025	144187251	209	922										
OCIAD2	132299	broad.mit.edu	37	chr4	48901920	48901920	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctctgtggatgtgcagttttGattttggacaaaacaacagg	11	6	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:48901920G>C	uc003gyt.2	-	3	292	c.89C>G	c.(88-90)TCA>TGA	p.S30*	OCIAD2_uc003gyu.2_Nonsense_Mutation_p.S30*	NM_001014446	NP_001014446	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2 isoform 1	30	OCIA.					endosome					0						GTGCAGTTTTGATTTTGGACA	0.393													0	0	0	0.010729	0	10	112										C	48901920	G	C	48901920	4	2	6	1	0	0	0	0	0	1	0	0	10818	1294	45	1	395	1	OCIAD2	4	48901920	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1934895	48901920	142252356	210	923										
TMPRSS11F	389208	broad.mit.edu	37	chr4	68935699	68935699	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaacttacgactgttgagaaGattcctcatctttttgctgt	8	8	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:68935699G>C	uc003hdt.1	-	6	590	c.541C>G	c.(541-543)CTT>GTT	p.L181V	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	181	Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						CTGTTGAGAAGATTCCTCATC	0.333													0	0	0	0.013114	0	38	205										C	68935699	G	C	68935699	3	2	6	1	0	0	0	0	1	0	0	0	16240	942	33	1	795	1	TMPRSS11F	4	68935699	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	20033779	68935699	122218577	211	924										
IL8	3576	broad.mit.edu	37	chr4	74607297	74607297	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgctaaagaacttagatgtCagtgcataaagacatactcc	8	8	1	3	rs149273289		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:74607297C>G	uc003hhe.2	+	2	204	c.103C>G	c.(103-105)CAG>GAG	p.Q35E	IL8_uc011cbh.1_Missense_Mutation_p.Q35E	NM_000584	NP_000575	P10145	IL8_HUMAN	interleukin 8 precursor	35					angiogenesis|calcium-mediated signaling|cell cycle arrest|cellular response to lipopolysaccharide|embryonic digestive tract development|G-protein coupled receptor protein signaling pathway|immune response|induction of positive chemotaxis|inflammatory response|negative regulation of cell proliferation|neutrophil activation|neutrophil chemotaxis|positive regulation of neutrophil chemotaxis|regulation of cell adhesion|regulation of retroviral genome replication	extracellular space|intracellular	chemokine activity|interleukin-8 receptor binding			ovary(2)	2	Breast(15;0.00102)		all cancers(17;0.00169)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)	LUSC - Lung squamous cell carcinoma(721;0.008)	Ketoprofen(DB01009)|Salbutamol(DB01001)|Simvastatin(DB00641)|Zileuton(DB00744)	ACTTAGATGTCAGTGCATAAA	0.423													0	0	0	0.006122	0	16	58										G	74607297	C	G	74607297	3	3	6	1	0	0	0	0	1	0	0	0	7706	827	29	1	109	1	IL8	4	74607297	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5671598	74607297	116546979	212	925										
CXCL5	6374	broad.mit.edu	37	chr4	74863775	74863775	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctttagaaaaggggcttctgGatcaagacaaatttccttcc	8	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:74863775G>C	uc003hhk.2	-	3	398	c.280C>G	c.(280-282)CCA>GCA	p.P94A		NM_002994	NP_002985	P42830	CXCL5_HUMAN	chemokine (C-X-C motif) ligand 5 precursor	94					cell-cell signaling|chemotaxis|immune response|positive regulation of cell proliferation|signal transduction	extracellular space	chemokine activity				0	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			GGGGCTTCTGGATCAAGACAA	0.433													0	0	0	0.012213	0	32	137										C	74863775	G	C	74863775	3	2	6	1	0	0	0	0	1	0	0	0	4087	1174	41	1	72	1	CXCL5	4	74863775	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	256478	74863775	116290501	213	926										
HPSE	10855	broad.mit.edu	37	chr4	84230599	84230599	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aataaaaatgtccaatacatCagggtttagaaaatcttcct	5	7	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:84230599C>T	uc003hoj.3	-	7	1039	c.940G>A	c.(940-942)GAT>AAT	p.D314N	HPSE_uc010ika.2_Missense_Mutation_p.D256N|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.D57N|HPSE_uc011cct.1_Missense_Mutation_p.D314N|HPSE_uc003hok.3_Missense_Mutation_p.D314N	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	314					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	TCCAATACATCAGGGTTTAGA	0.279													0	0	0	0.006122	0	15	74										T	84230599	C	T	84230599	3	4	6	1	0	0	0	0	1	0	0	0	7344	826	29	1	715	1	HPSE	4	84230599	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	9366824	84230599	106923677	214	927										
HPSE	10855	broad.mit.edu	37	chr4	84231203	84231203	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgatgccatgtaactgaatCaatcacttctccaccagcct	5	14	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:84231203C>G	uc003hoj.3	-	6	970	c.871G>C	c.(871-873)GAT>CAT	p.D291H	HPSE_uc010ika.2_Missense_Mutation_p.D233H|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.D34H|HPSE_uc011cct.1_Missense_Mutation_p.D291H|HPSE_uc003hok.3_Missense_Mutation_p.D291H	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	291				D -> G (in Ref. 9; BAD96706).	carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	GTAACTGAATCAATCACTTCT	0.308													0	0	0	0.005524	0	34	185										G	84231203	C	G	84231203	3	3	6	1	0	0	0	0	1	0	0	0	7344	826	29	1	788	1	HPSE	4	84231203	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	604	84231203	106923073	215	928										
HPGDS	27306	broad.mit.edu	37	chr4	95223298	95223298	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agatataaaacatactcacaGagttaccaataagccattct	4	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:95223298G>A	uc003hte.1	-	5	525	c.434C>T	c.(433-435)TCT>TTT	p.S145F		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	145	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)	CATACTCACAGAGTTACCAAT	0.363													0	0	0	0.01441	0	76	195										A	95223298	G	A	95223298	3	1	6	1	0	0	0	0	1	0	0	0	7335	956	33	1	173	1	HPGDS	4	95223298	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	10992095	95223298	95930978	216	929										
SEC24B	10427	broad.mit.edu	37	chr4	110442741	110442741	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttccttgggtgcaggacttCtgcaatccagagaagatcct	10	11	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:110442741C>T	uc003hzk.2	+	14	2522	c.2467C>T	c.(2467-2469)CTG>TTG	p.L823L	SEC24B_uc003hzl.2_Silent_p.L788L|SEC24B_uc011cfp.1_Silent_p.L853L|SEC24B_uc011cfq.1_Silent_p.L822L|SEC24B_uc011cfr.1_Silent_p.L787L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	823					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGCAGGACTTCTGCAATCCAG	0.383													0	0	0	0.001855	0	11	31										T	110442741	C	T	110442741	2	4	6	1	0	0	0	0	0	0	0	1	13995	912	32	1		1	SEC24B	4	110442741	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	15219443	110442741	80711535	217	930										
NDST3	9348	broad.mit.edu	37	chr4	119163257	119163257	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acagtgatggatgaagtacaGaagtttctaggagtcttgcc	12	6	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:119163257G>C	uc003ibx.2	+	12	2755	c.2352G>C	c.(2350-2352)CAG>CAC	p.Q784H		NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	784	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ATGAAGTACAGAAGTTTCTAG	0.303													0	0	0	0.01441	0	46	146										C	119163257	G	C	119163257	3	2	6	1	0	0	0	0	1	0	0	0	10257	933	33	1	2394	1	NDST3	4	119163257	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8720516	119163257	71991019	218	931										
FAT4	79633	broad.mit.edu	37	chr4	126241888	126241888	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	catcggtacatctgtcatttCagtgactgcacatgaccctg	8	12	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:126241888C>T	uc003ifj.3	+	1	4322	c.4322C>T	c.(4321-4323)TCA>TTA	p.S1441L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1441	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTGTCATTTCAGTGACTGCA	0.418													0	0	0	0.009718	0	38	149										T	126241888	C	T	126241888	3	4	6	1	0	0	0	0	1	0	0	0	5692	838	29	1	4324	1	FAT4	4	126241888	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7078631	126241888	64912388	219	932										
FAT4	79633	broad.mit.edu	37	chr4	126371358	126371358	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttatcacagtcactgcaaagGataagggaaaccctccactt	7	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:126371358G>C	uc003ifj.3	+	9	9187	c.9187G>C	c.(9187-9189)GAT>CAT	p.D3063H	FAT4_uc011cgp.1_Missense_Mutation_p.D1361H|FAT4_uc003ifi.1_Missense_Mutation_p.D541H	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3063	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CACTGCAAAGGATAAGGGAAA	0.418													0	0	0	0.004656	0	25	65										C	126371358	G	C	126371358	3	2	6	1	0	0	0	0	1	0	0	0	5692	1174	41	1	9221	1	FAT4	4	126371358	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	129470	126371358	64782918	220	933										
FAT4	79633	broad.mit.edu	37	chr4	126371891	126371891	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagtcatctgacagtgacctCtttgtcattgaccctaacac	6	13	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:126371891C>G	uc003ifj.3	+	9	9720	c.9720C>G	c.(9718-9720)CTC>CTG	p.L3240L	FAT4_uc011cgp.1_Silent_p.L1538L|FAT4_uc003ifi.1_Silent_p.L718L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3240	Cadherin 31.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACAGTGACCTCTTTGTCATTG	0.443													0	0	0	0.012319	0	23	117										G	126371891	C	G	126371891	2	3	6	1	0	0	0	0	0	0	0	1	5692	900	32	1		1	FAT4	4	126371891	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	533	126371891	64782385	221	934										
C4orf29	80167	broad.mit.edu	37	chr4	128938605	128938605	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctctcttgcactggctagaGagggaaggttacggcccttt	13	10	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:128938605G>A	uc003ifr.2	+	9	876	c.558G>A	c.(556-558)GAG>GAA	p.E186E	C4orf29_uc003ifs.2_Silent_p.E80E|C4orf29_uc003ift.2_Silent_p.E17E|C4orf29_uc003ifu.2_Silent_p.E17E|C4orf29_uc010inz.2_Intron|C4orf29_uc003ifv.2_Silent_p.E17E	NM_001039717	NP_001034806	Q0P651	CD029_HUMAN	hypothetical protein LOC80167 precursor	186						extracellular region				ovary(1)	1						ACTGGCTAGAGAGGGAAGGTT	0.418													0	0	0	0.00308	0	8	16										A	128938605	G	A	128938605	2	1	6	1	0	0	0	0	0	0	0	1	2259	933	33	1		1	C4orf29	4	128938605	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2566714	128938605	62215671	222	935										
USP38	84640	broad.mit.edu	37	chr4	144107121	144107121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttctgtcaacagctggttcGaacgataggccatttccagt	10	10	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:144107121G>A	uc003ijb.2	+	1	1052	c.518G>A	c.(517-519)CGA>CAA	p.R173Q	USP38_uc003ija.3_Missense_Mutation_p.R173Q|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	173					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					CAGCTGGTTCGAACGATAGGC	0.537													0	0	0	0.005524	0	37	135										A	144107121	G	A	144107121	3	1	6	1	0	0	0	0	1	0	0	0	17066	1058	37	1	520	1	USP38	4	144107121	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	15168516	144107121	47047155	223	936										
PRSS48	345062	broad.mit.edu	37	chr4	152204409	152204409	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagacaagatttgtgctggtGatactcaaaacatgaaggat	10	5	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:152204409G>T	uc011cif.1	+	4	622	c.622G>T	c.(622-624)GAT>TAT	p.D208Y	PRSS48_uc011cig.1_Missense_Mutation_p.D65Y	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	208	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)	1						TTGTGCTGGTGATACTCAAAA	0.413													1	0	1.28384e-07	0.012319	1.30923e-07	22	81										T	152204409	G	T	152204409	3	4	6	1	0	0	0	0	1	0	0	0	12630	1290	45	3	636	3	PRSS48	4	152204409	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8097288	152204409	38949867	224	937										
FBXW7	55294	broad.mit.edu	37	chr4	153249367	153249367	+	Frame_Shift_Del	DEL	C	C	-													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gattttcccttaccttttttCatgaagatgcatacaacgca							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:153249367delC	uc003ims.2	-	9	1560	c.1411delG	c.(1411-1413)GAAfs	p.E471fs	FBXW7_uc011cii.1_Frame_Shift_Del_p.E471fs|FBXW7_uc003imt.2_Frame_Shift_Del_p.E471fs|FBXW7_uc011cih.1_Frame_Shift_Del_p.E295fs|FBXW7_uc003imq.2_Frame_Shift_Del_p.E391fs|FBXW7_uc003imr.2_Frame_Shift_Del_p.E353fs	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	471	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTTTTTTCATGAAGATGC	0.413			Mis|N|D|F		colorectal|endometrial|T-ALL													51	179	---	---								-	153249367	C	-	153249367	7	5	6	1	0	1	0	1	0	0	0	0	5769	835	29	0	728	0	FBXW7	4	153249367	Frame_Shift_Del	DEL	C	TCGA-BT-A0YX-01A-11D-A10S-08	1044958	153249367	37904909	225	938										
FBXW7	55294	broad.mit.edu	37	chr4	153249501	153249501	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgttgtctctcatttgtgatGaccatactccacctgtatgt	7	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:153249501G>A	uc003ims.2	-	9	1426	c.1277C>T	c.(1276-1278)TCA>TTA	p.S426L	FBXW7_uc011cii.1_Missense_Mutation_p.S426L|FBXW7_uc003imt.2_Missense_Mutation_p.S426L|FBXW7_uc011cih.1_Missense_Mutation_p.S250L|FBXW7_uc003imq.2_Missense_Mutation_p.S346L|FBXW7_uc003imr.2_Missense_Mutation_p.S308L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	426	WD 2.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CATTTGTGATGACCATACTCC	0.378			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.01441	0	67	229										A	153249501	G	A	153249501	3	1	6	1	0	0	0	0	1	0	0	0	5769	1294	45	1	862	1	FBXW7	4	153249501	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	134	153249501	37904775	226	939										
RAPGEF2	9693	broad.mit.edu	37	chr4	160260433	160260433	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgaggtctctgtcacacctGagggagtaatcaaacaaaga	11	8	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:160260433G>T	uc003iqg.3	+	13	2288	c.1978G>T	c.(1978-1980)GAG>TAG	p.E660*		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	660	Ras-associating.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TGTCACACCTGAGGGAGTAAT	0.433													1	0	4.86159e-25	0.01441	5.0578e-25	50	202										T	160260433	G	T	160260433	4	4	6	1	0	0	0	0	0	1	0	0	13044	1291	45	3	2028	3	RAPGEF2	4	160260433	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7010932	160260433	30893843	227	940										
KLHL2	11275	broad.mit.edu	37	chr4	166220763	166220763	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acagagcagcgtatattaatGaagagtgtccggacccggct	12	9	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:166220763G>T	uc003irb.2	+	8	1135	c.876G>T	c.(874-876)ATG>ATT	p.M292I	KLHL2_uc011cjm.1_Missense_Mutation_p.M296I|KLHL2_uc003irc.2_Missense_Mutation_p.M204I|KLHL2_uc010ira.2_5'UTR	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	292					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		GTATATTAATGAAGAGTGTCC	0.433													1	0	7.07758e-08	0.004656	7.22552e-08	27	69										T	166220763	G	T	166220763	3	4	6	1	0	0	0	0	1	0	0	0	8374	1290	45	3	948	3	KLHL2	4	166220763	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5960330	166220763	24933513	228	941										
DDX60	55601	broad.mit.edu	37	chr4	169215078	169215078	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggccagacttgtgtaagcaGagatacagtcttgtgtgcct	12	8	1	2	rs138195535		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:169215078G>C	uc003irp.2	-	7	1034	c.742C>G	c.(742-744)CTG>GTG	p.L248V		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	248							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGTGTAAGCAGAGATACAGTC	0.323													0	0	0	0.00278	0	23	92										C	169215078	G	C	169215078	3	2	6	1	0	0	0	0	1	0	0	0	4378	933	33	1	4524	1	DDX60	4	169215078	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2994315	169215078	21939198	229	942										
WDR17	116966	broad.mit.edu	37	chr4	177052884	177052884	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaagtgggattttcttagaGacttggtatgtatgtagtca	12	3	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:177052884G>C	uc003iuj.2	+	8	1321	c.1165G>C	c.(1165-1167)GAC>CAC	p.D389H	WDR17_uc003iuk.2_Missense_Mutation_p.D365H|WDR17_uc003ium.3_Missense_Mutation_p.D365H|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	389										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TTTTCTTAGAGACTTGGTATG	0.338													0	0	0	0.00499	0	16	252										C	177052884	G	C	177052884	3	2	6	1	0	0	0	0	1	0	0	0	17274	942	33	1	1191	1	WDR17	4	177052884	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7837806	177052884	14101392	230	943										
DCTD	1635	broad.mit.edu	37	chr4	183836719	183836719	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcttgcaggaaacttcactCatgttgggtctagaagaaaa	9	7	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:183836719C>G	uc003ivf.2	-	2	177	c.3G>C	c.(1-3)ATG>ATC	p.M1I	DCTD_uc003ivg.2_Missense_Mutation_p.M12I|DCTD_uc010irw.2_5'UTR|DCTD_uc003ivh.2_5'UTR	NM_001921	NP_001912	P32321	DCTD_HUMAN	dCMP deaminase isoform b	1					nucleotide biosynthetic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide metabolic process	cytosol	dCMP deaminase activity|zinc ion binding				0		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00666)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.202)		all cancers(43;1.65e-24)|Epithelial(43;3.44e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.39e-10)|Colorectal(24;4.69e-07)|COAD - Colon adenocarcinoma(29;7.07e-05)|STAD - Stomach adenocarcinoma(60;0.000118)|GBM - Glioblastoma multiforme(59;0.000472)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.0419)		AAACTTCACTCATGTTGGGTC	0.398													0	0	0	0.009535	0	29	111										G	183836719	C	G	183836719	3	3	6	1	0	0	0	0	1	0	0	0	4305	826	29	1	553	1	DCTD	4	183836719	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6783835	183836719	7317557	231	944										
WWC2	80014	broad.mit.edu	37	chr4	184233512	184233512	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggctgaacagtccaaagaaGagcagaagcaaggtctgaat	12	7	1	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:184233512G>C	uc010irx.2	+	22	3585	c.3403G>C	c.(3403-3405)GAG>CAG	p.E1135Q	WWC2_uc003ivk.3_Missense_Mutation_p.E930Q|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.E817Q|WWC2_uc003ivn.3_Missense_Mutation_p.E650Q|WWC2_uc010irz.2_Missense_Mutation_p.E476Q|WWC2_uc003ivo.3_Missense_Mutation_p.E263Q	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1135	Potential.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		GTCCAAAGAAGAGCAGAAGCA	0.478													0	0	0	0.003755	0	33	132										C	184233512	G	C	184233512	3	2	6	1	0	0	0	0	1	0	0	0	17409	943	33	1	3489	1	WWC2	4	184233512	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	396793	184233512	6920764	232	945										
SNX25	83891	broad.mit.edu	37	chr4	186188198	186188198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcttgcccagctggcgtacaGagagcaaatgaatgagcatc	12	10	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr4:186188198G>A	uc003ixh.2	+	5	677	c.488G>A	c.(487-489)AGA>AAA	p.R163K		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	163	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		CTGGCGTACAGAGAGCAAATG	0.458													0	0	0	0.01441	0	53	146										A	186188198	G	A	186188198	3	1	6	1	0	0	0	0	1	0	0	0	14896	942	33	1	502	1	SNX25	4	186188198	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1954686	186188198	4966078	233	946										
CEP72	55722	broad.mit.edu	37	chr5	637659	637659	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggataccgaggactcggcctCttctcagaagttggatttgt	12	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:637659C>G	uc003jbf.2	+	7	1004	c.932C>G	c.(931-933)TCT>TGT	p.S311C	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	311					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			GACTCGGCCTCTTCTCAGAAG	0.532													0	0	0	0.006122	0	16	66										G	637659	C	G	637659	3	3	6	1	0	0	0	0	1	0	0	0	3260	913	32	1	958	1	CEP72	5	637659	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		637659	180277601	234	947										
SLC12A7	10723	broad.mit.edu	37	chr5	1064231	1064231	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcaggaagggcagcagcatGagcatgccgccgtcgtgcac	15	12	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:1064231G>C	uc003jbu.2	-	19	2640	c.2574C>G	c.(2572-2574)CTC>CTG	p.L858L		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	858	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GCAGCAGCATGAGCATGCCGC	0.697													0	0	0	0.000602	0	5	20										C	1064231	G	C	1064231	2	2	6	1	0	0	0	0	0	0	0	1	14388	1277	45	1		1	SLC12A7	5	1064231	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	426572	1064231	179851029	235	948										
SLC6A19	340024	broad.mit.edu	37	chr5	1221314	1221314	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggccacaagcccaacatcttCtggcaagtcacgtggcgcgt	11	14	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:1221314C>T	uc003jbw.3	+	11	1643	c.1587C>T	c.(1585-1587)TTC>TTT	p.F529F		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	529	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCAACATCTTCTGGCAAGTCA	0.547													0	0	0	0.008291	0	10	32										T	1221314	C	T	1221314	2	4	6	1	0	0	0	0	0	0	0	1	14682	912	32	1		1	SLC6A19	5	1221314	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	157083	1221314	179693946	236	949										
ADCY2	108	broad.mit.edu	37	chr5	7816985	7816985	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgtttgttctcaggagcccGagcggcagtacatgcacatt	12	10	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:7816985G>A	uc003jdz.1	+	23	2957	c.2890G>A	c.(2890-2892)GAG>AAG	p.E964K	ADCY2_uc011cmo.1_Missense_Mutation_p.E784K|ADCY2_uc010itm.1_Missense_Mutation_p.E160K	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	964	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TCAGGAGCCCGAGCGGCAGTA	0.502											OREG0016499	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	20	89										A	7816985	G	A	7816985	3	1	6	1	0	0	0	0	1	0	0	0	294	1059	37	1	2980	1	ADCY2	5	7816985	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6595671	7816985	173098275	237	950										
MARCH6	10299	broad.mit.edu	37	chr5	10403539	10403539	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaatgtttgatgctactctGaaagatcgagaactgagctt	10	6	1	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:10403539G>C	uc003jet.1	+	15	1401	c.1218G>C	c.(1216-1218)CTG>CTC	p.L406L	MARCH6_uc011cmu.1_Silent_p.L358L|MARCH6_uc003jeu.1_Silent_p.L104L|MARCH6_uc011cmv.1_Silent_p.L301L	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	406	Extracellular (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						ATGCTACTCTGAAAGATCGAG	0.418													0	0	0	0.007291	0	28	79										C	10403539	G	C	10403539	2	2	6	1	0	0	0	0	0	0	0	1	9305	1277	45	1		1	MARCH6	5	10403539	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2586554	10403539	170511721	238	951										
MARCH11	441061	broad.mit.edu	37	chr5	16177875	16177875	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taatggctataacatggtatCtataacagcaaagttcacag	7	7	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:16177875C>T	uc003jfo.2	-	2	866	c.653G>A	c.(652-654)AGA>AAA	p.R218K	uc003jfp.2_5'Flank	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	218	RING-CH-type.					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AACATGGTATCTATAACAGCA	0.398													0	0	0	0.001855	0	13	51										T	16177875	C	T	16177875	3	4	6	1	0	0	0	0	1	0	0	0	9300	913	32	1	567	1	MARCH11	5	16177875	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5774336	16177875	164737385	239	952										
PTGER4	5734	broad.mit.edu	37	chr5	40692015	40692015	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atatatatcctcctgagaaaGacagtgctcagtaaagcaat	7	8	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:40692015G>C	uc003jlz.2	+	3	1594	c.1002G>C	c.(1000-1002)AAG>AAC	p.K334N		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	334	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						TCCTGAGAAAGACAGTGCTCA	0.507													0	0	0	0.01441	0	54	145										C	40692015	G	C	40692015	3	2	6	1	0	0	0	0	1	0	0	0	12745	933	33	1	1008	1	PTGER4	5	40692015	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	24514140	40692015	140223245	240	953										
GPBP1	65056	broad.mit.edu	37	chr5	56545357	56545357	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaagcattgaaaagagacaGagtagaagaggaacatgaag	13	3	0	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:56545357G>C	uc003jrh.3	+	9	2200	c.926G>C	c.(925-927)AGA>ACA	p.R309T	GPBP1_uc010iwg.2_Missense_Mutation_p.R329T|GPBP1_uc003jri.3_Missense_Mutation_p.R138T|GPBP1_uc003jrj.3_Missense_Mutation_p.R301T|GPBP1_uc003jrk.3_Missense_Mutation_p.R316T|GPBP1_uc003jrl.3_RNA	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		AAAAGAGACAGAGTAGAAGAG	0.373													0	0	0	0.00499	0	17	48										C	56545357	G	C	56545357	3	2	6	1	0	0	0	0	1	0	0	0	6595	942	33	1	977	1	GPBP1	5	56545357	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	15853342	56545357	124369903	241	954										
SLC30A5	64924	broad.mit.edu	37	chr5	68412387	68412387	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctaaaacaaattcttgaggaGagtgactctaggcagatctt	9	7	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:68412387G>A	uc003jvh.2	+	10	1440	c.1239G>A	c.(1237-1239)GAG>GAA	p.E413E	SLC30A5_uc003jvj.2_RNA|SLC30A5_uc003jvk.2_Silent_p.E142E|SLC30A5_uc003jvi.2_Silent_p.E242E	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	413	Cytoplasmic (Potential).				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		TTCTTGAGGAGAGTGACTCTA	0.328													0	0	0	0.008291	0	10	68										A	68412387	G	A	68412387	2	1	6	1	0	0	0	0	0	0	0	1	14558	933	33	1		1	SLC30A5	5	68412387	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11867030	68412387	112502873	242	955										
CCDC125	202243	broad.mit.edu	37	chr5	68616292	68616292	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaggccataccctaaatcacCttctgtcatgtcatcctctt	5	14	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:68616292C>A	uc003jvv.1	-	1	119	c.76G>T	c.(76-78)GGT>TGT	p.G26C	CCDC125_uc003jvx.1_Missense_Mutation_p.G26C|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_Translation_Start_Site|CCDC125_uc003jvz.1_Missense_Mutation_p.G26C	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	26						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		CCTAAATCACCTTCTGTCATG	0.433													1	0	6.44725e-10	0.014323	6.60381e-10	21	137										A	68616292	C	A	68616292	3	1	6	1	0	0	0	0	1	0	0	0	2761	681	24	4	1503	4	CCDC125	5	68616292	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	203905	68616292	112298968	243	956										
MAP1B	4131	broad.mit.edu	37	chr5	71491837	71491837	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagaaggagagagaagtcacCaaaggtcctgccgagtcccc	12	12	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:71491837C>T	uc003kbw.3	+	5	2896	c.2655C>T	c.(2653-2655)ACC>ACT	p.T885T	MAP1B_uc010iyw.1_Silent_p.T902T|MAP1B_uc010iyx.1_Silent_p.T759T|MAP1B_uc010iyy.1_Silent_p.T759T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	885						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GAGAAGTCACCAAAGGTCCTG	0.547													0	0	0	0.01441	0	50	181										T	71491837	C	T	71491837	2	4	6	1	0	0	0	0	0	0	0	1	9228	581	21	2		2	MAP1B	5	71491837	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2875545	71491837	109423423	244	957										
BHMT2	23743	broad.mit.edu	37	chr5	78373343	78373343	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagtggggaggttgtgattgGagatggcagctttctcatta	16	4	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:78373343G>C	uc003kft.2	+	2	97	c.74G>C	c.(73-75)GGA>GCA	p.G25A	BHMT2_uc011cth.1_Missense_Mutation_p.G25A	NM_017614	NP_060084	Q9H2M3	BHMT2_HUMAN	betaine-homocysteine methyltransferase 2	25	Hcy-binding.				methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GTTGTGATTGGAGATGGCAGC	0.488													0	0	0	0.004878	0	38	159										C	78373343	G	C	78373343	3	2	6	1	0	0	0	0	1	0	0	0	1426	1174	41	1	80	1	BHMT2	5	78373343	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6881506	78373343	102541917	245	958										
CMYA5	202333	broad.mit.edu	37	chr5	79027767	79027767	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtatctgagcagttcagttCatcacagaagcaaaaagctg	9	8	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:79027767C>T	uc003kgc.2	+	2	3251	c.3179C>T	c.(3178-3180)TCA>TTA	p.S1060L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1060						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CAGTTCAGTTCATCACAGAAG	0.428													0	0	0	0.008291	0	9	36										T	79027767	C	T	79027767	3	4	6	1	0	0	0	0	1	0	0	0	3590	838	29	1	3185	1	CMYA5	5	79027767	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	654424	79027767	101887493	246	959										
GPR98	84059	broad.mit.edu	37	chr5	90449160	90449160	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggatatggccaggggtcactGatagccgatgaggagtccca	15	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:90449160G>A	uc003kju.2	+	89	18843	c.18747G>A	c.(18745-18747)CTG>CTA	p.L6249L	GPR98_uc003kjt.2_Silent_p.L3955L|GPR98_uc003kjw.2_Silent_p.L1910L|GPR98_uc003kjx.2_Silent_p.L277L	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	6249	Cytoplasmic (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGGGGTCACTGATAGCCGATG	0.478													0	0	0	0.000602	0	5	27										A	90449160	G	A	90449160	2	1	6	1	0	0	0	0	0	0	0	1	6721	1277	45	1		1	GPR98	5	90449160	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11421393	90449160	90466100	247	960										
CHD1	1105	broad.mit.edu	37	chr5	98207807	98207807	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taatcatttcccagcttccaTatccatattcatagatgcca	3	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:98207807T>C	uc003knf.2	-	27	3957	c.3809A>G	c.(3808-3810)TAT>TGT	p.Y1270C	CHD1_uc010jbn.2_Translation_Start_Site	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1270					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CCAGCTTCCATATCCATATTC	0.353													0	0	0	0.012213	0	34	144										C	98207807	T	C	98207807	3	2	6	1	0	0	0	0	1	0	0	0	3323	1406	49	5	1359	5	CHD1	5	98207807	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	7758647	98207807	82707453	248	961										
SLCO4C1	353189	broad.mit.edu	37	chr5	101593786	101593786	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ataaagacagcattcttcatCaaattctaaagaaaaaaata	3	6	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:101593786C>G	uc003knm.2	-	7	1421	c.1134G>C	c.(1132-1134)TTG>TTC	p.L378F		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	378	Helical; Name=7; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		CATTCTTCATCAAATTCTAAA	0.274													0	0	0	0.00278	0	23	55										G	101593786	C	G	101593786	3	3	6	1	0	0	0	0	1	0	0	0	14730	825	29	1	1068	1	SLCO4C1	5	101593786	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3385979	101593786	79321474	249	962										
NUDT12	83594	broad.mit.edu	37	chr5	102891757	102891757	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggttgggcaaaacttgtatCgactgtgccaggcaagaaca	12	8	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:102891757C>T	uc003koi.2	-	4	932	c.839G>A	c.(838-840)CGA>CAA	p.R280Q	NUDT12_uc011cvb.1_Missense_Mutation_p.R262Q	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	280						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		AAACTTGTATCGACTGTGCCA	0.353													0	0	0	0.012319	0	19	92										T	102891757	C	T	102891757	3	4	6	1	0	0	0	0	1	0	0	0	10728	884	31	1	565	1	NUDT12	5	102891757	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1297971	102891757	78023503	250	963										
FER	2241	broad.mit.edu	37	chr5	108281850	108281850	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggaaagaaaggagaggctatCcaaatttgaatctattcgtc	10	6	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:108281850C>G	uc003kop.1	+	11	1640	c.1256C>G	c.(1255-1257)TCC>TGC	p.S419C	FER_uc011cvf.1_RNA|FER_uc011cvg.1_Missense_Mutation_p.S244C	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	419					intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GAGAGGCTATCCAAATTTGAA	0.378													0	0	0	0.004878	0	32	112										G	108281850	C	G	108281850	3	3	6	1	0	0	0	0	1	0	0	0	5813	855	30	1	1290	1	FER	5	108281850	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5390093	108281850	72633410	251	964										
CAMK4	814	broad.mit.edu	37	chr5	110818485	110818485	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggttctttattatttcaggtCagaaaattaattgttttgga	8	3	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:110818485C>T	uc011cvj.1	+	11	930	c.831C>T	c.(829-831)GTC>GTT	p.V277V	CAMK4_uc003kpf.2_Silent_p.V277V|CAMK4_uc010jbv.2_Silent_p.V80V|CAMK4_uc003kpg.2_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	277	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TATTTCAGGTCAGAAAATTAA	0.418													0	0	0	0.003163	0	15	95										T	110818485	C	T	110818485	2	4	6	1	0	0	0	0	0	0	0	1	2605	813	29	1		1	CAMK4	5	110818485	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2536635	110818485	70096775	252	965										
TSSK1B	83942	broad.mit.edu	37	chr5	112769841	112769841	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttggagcgtgggaagttgacGcggtgctccttctggatacg	16	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:112769841G>A	uc003kqm.2	-	1	888	c.696C>T	c.(694-696)CGC>CGT	p.R232R	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	232	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.R232H(1)		ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		GGAAGTTGACGCGGTGCTCCT	0.587													0	0	0	0.00499	0	16	65										A	112769841	G	A	112769841	2	1	6	1	0	0	0	0	0	0	0	1	16665	1074	38	2		2	TSSK1B	5	112769841	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1951356	112769841	68145419	253	966										
KCNN2	3781	broad.mit.edu	37	chr5	113831654	113831654	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggagtgaagacttcgagaaGaggattgttaccctggaaac	13	6	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:113831654G>C	uc003kqo.2	+	8	1972	c.1515G>C	c.(1513-1515)AAG>AAC	p.K505N	KCNN2_uc003kqp.2_Missense_Mutation_p.K157N|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	505						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		ACTTCGAGAAGAGGATTGTTA	0.428													0	0	0	0.004878	0	38	160										C	113831654	G	C	113831654	3	2	6	1	0	0	0	0	1	0	0	0	8079	933	33	1	1545	1	KCNN2	5	113831654	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1061813	113831654	67083606	254	967										
SHROOM1	134549	broad.mit.edu	37	chr5	132160910	132160910	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggaacccaagacttcgcctGaagcgctccgactccgactg	10	15	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:132160910G>A	uc003kxx.2	-	4	1728	c.923C>T	c.(922-924)TCA>TTA	p.S308L	SHROOM1_uc003kxy.1_Missense_Mutation_p.S308L	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	308					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACTTCGCCTGAAGCGCTCCG	0.617													0	0	0	0.001855	0	11	34										A	132160910	G	A	132160910	3	1	6	1	0	0	0	0	1	0	0	0	14293	1294	45	1	1663	1	SHROOM1	5	132160910	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	18329256	132160910	48754350	255	968										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139905956	139905956	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtgatggatgtgaattcctCtaaatacccctcactgctcc	7	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:139905956C>G	uc003lfs.1	+	26	4992	c.4868C>G	c.(4867-4869)TCT>TGT	p.S1623C	ANKHD1_uc003lfr.2_Missense_Mutation_p.S1623C|ANKHD1_uc003lfu.1_Missense_Mutation_p.S1103C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S362C|ANKHD1_uc003lfw.2_Missense_Mutation_p.S261C|ANKHD1_uc010jfl.2_Missense_Mutation_p.S58C|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1623						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAATTCCTCTAAATACCCC	0.393													0	0	0	0.010818	0	33	104										G	139905956	C	G	139905956	3	3	6	1	0	0	0	0	1	0	0	0	629	913	32	1	4970	1	ANKHD1-EIF4EBP3	5	139905956	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7745046	139905956	41009304	256	969										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139905979	139905979	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatacccctcactgctccttCattcccaagaagaaaagaca	4	14	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:139905979C>G	uc003lfs.1	+	26	5015	c.4891C>G	c.(4891-4893)CAT>GAT	p.H1631D	ANKHD1_uc003lfr.2_Missense_Mutation_p.H1631D|ANKHD1_uc003lfu.1_Missense_Mutation_p.H1111D|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.H370D|ANKHD1_uc003lfw.2_Missense_Mutation_p.H269D|ANKHD1_uc010jfl.2_Missense_Mutation_p.H66D|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1631						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTGCTCCTTCATTCCCAAGA	0.418													0	0	0	0.003755	0	35	96										G	139905979	C	G	139905979	3	3	6	1	0	0	0	0	1	0	0	0	629	826	29	1	4993	1	ANKHD1-EIF4EBP3	5	139905979	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	23	139905979	41009281	257	970										
PCDHA7	56141	broad.mit.edu	37	chr5	140214299	140214299	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccacctggaggtgatcgtgGaaaggccgctgcaggttttc	14	10	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140214299G>A	uc003lhq.2	+	1	331	c.331G>A	c.(331-333)GAA>AAA	p.E111K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.E111K	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	111	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGATCGTGGAAAGGCCGCT	0.557													0	0	0	0.004878	0	37	351										A	140214299	G	A	140214299	3	1	6	1	0	0	0	0	1	0	0	0	11529	1175	41	1	333	1	PCDHA7	5	140214299	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	308320	140214299	40700961	258	971										
PCDHA9	9752	broad.mit.edu	37	chr5	140228411	140228411	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccacctggaggtgatcgtaGacaggccgctgcaggttttc	13	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140228411G>A	uc003lhu.2	+	1	1055	c.331G>A	c.(331-333)GAC>AAC	p.D111N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.D111N	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	111	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGATCGTAGACAGGCCGCT	0.547													0	0	0	0.00333	0	12	205										A	140228411	G	A	140228411	3	1	6	1	0	0	0	0	1	0	0	0	11531	942	33	1	333	1	PCDHA9	5	140228411	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14112	140228411	40686849	259	972										
PCDHB7	56129	broad.mit.edu	37	chr5	140553716	140553716	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggacacccaggctgaaaaccGagcacaacataaccgtgctg	10	13	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140553716G>A	uc003lit.2	+	1	1474	c.1300G>A	c.(1300-1302)GAG>AAG	p.E434K		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	434	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGAAAACCGAGCACAACAT	0.537													0	0	0	0.005524	0	40	105										A	140553716	G	A	140553716	3	1	6	1	0	0	0	0	1	0	0	0	11547	1059	37	1	1302	1	PCDHB7	5	140553716	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	325305	140553716	40361544	260	973										
PCDHB14	56122	broad.mit.edu	37	chr5	140605331	140605331	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtcccagagctaccaatacGaggtgtgtctgacaggaggt	13	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140605331G>A	uc003ljb.2	+	1	2254	c.2254G>A	c.(2254-2256)GAG>AAG	p.E752K	PCDHB14_uc011dal.1_Missense_Mutation_p.E599K	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	752	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTACCAATACGAGGTGTGTCT	0.572													0	0	0	0.01441	0	42	154										A	140605331	G	A	140605331	3	1	6	1	0	0	0	0	1	0	0	0	11539	1059	37	1	2256	1	PCDHB14	5	140605331	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	51615	140605331	40309929	261	974										
PCDHGA7	56108	broad.mit.edu	37	chr5	140763130	140763130	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgatggcggcgacccgcccCgatccagcaccgcccacatc	10	20	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140763130C>T	uc003lka.1	+	1	664	c.664C>T	c.(664-666)CGA>TGA	p.R222*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Nonsense_Mutation_p.R222*	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	222	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACCCGCCCCGATCCAGCAC	0.607													0	0	0	0.001984	0	7	15										T	140763130	C	T	140763130	4	4	6	1	0	0	0	0	0	1	0	0	11559	644	23	2	666	2	PCDHGA7	5	140763130	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	157799	140763130	40152130	262	975										
PCDHGA9	56107	broad.mit.edu	37	chr5	140783493	140783493	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatacaagctgaagatggtgGgggattgaaagggtggacaa	16	3	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140783493G>A	uc003lkh.1	+	1	974	c.974G>A	c.(973-975)GGG>GAG	p.G325E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.G325E	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	325	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGATGGTGGGGGATTGAAA	0.378													0	0	0	0.01441	0	41	131										A	140783493	G	A	140783493	3	1	6	1	0	0	0	0	1	0	0	0	11561	1232	43	2	976	2	PCDHGA9	5	140783493	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	20363	140783493	40131767	263	976										
PCDHGC5	56097	broad.mit.edu	37	chr5	140870089	140870089	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcatcgagctgctggccagcGatgctggttcaccttcccta	10	14	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:140870089G>A	uc003lla.1	+	1	1282	c.1282G>A	c.(1282-1284)GAT>AAT	p.D428N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Missense_Mutation_p.D428N	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	428	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGCCAGCGATGCTGGTTC	0.512													0	0	0	0.01441	0	76	244										A	140870089	G	A	140870089	3	1	6	1	0	0	0	0	1	0	0	0	11571	1058	37	1	1284	1	PCDHGC5	5	140870089	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	86596	140870089	40045171	264	977										
GLRA1	2741	broad.mit.edu	37	chr5	151231107	151231107	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgggaatatacatctgaatCaggtagtaacccatctgccg	9	10	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:151231107C>G	uc003lut.2	-	7	1043	c.756G>C	c.(754-756)CTG>CTC	p.L252L	GLRA1_uc003lur.2_Silent_p.L252L|GLRA1_uc003lus.2_Silent_p.L169L	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	252	Helical; (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ACATCTGAATCAGGTAGTAAC	0.468													0	0	0	0.008871	0	20	88										G	151231107	C	G	151231107	2	3	6	1	0	0	0	0	0	0	0	1	6454	813	29	1		1	GLRA1	5	151231107	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	10361018	151231107	29684153	265	978										
MRPL22	29093	broad.mit.edu	37	chr5	154330479	154330479	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttatcctccacaactgcctgGagaacctcggagaccagcag	9	14	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:154330479G>C	uc003lvy.3	+	3	214	c.176G>C	c.(175-177)GGA>GCA	p.G59A	MRPL22_uc003lvz.3_Intron	NM_014180	NP_054899	Q9NWU5	RM22_HUMAN	mitochondrial ribosomal protein L22 isoform a	59					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAACTGCCTGGAGAACCTCGG	0.373													0	0	0	0.00632	0	26	73										C	154330479	G	C	154330479	3	2	6	1	0	0	0	0	1	0	0	0	9788	1174	41	1	186	1	MRPL22	5	154330479	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3099372	154330479	26584781	266	979										
C5orf40	408263	broad.mit.edu	37	chr5	156770349	156770349	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtagagagtggaaggggcaaGatgttccagcaccacggagc	16	8	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:156770349G>C	uc003lwu.2	-	2	384	c.196C>G	c.(196-198)CTT>GTT	p.L66V	CYFIP2_uc003lwq.2_Intron|CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Intron|CYFIP2_uc003lws.2_Intron|CYFIP2_uc003lwt.2_Intron|CYFIP2_uc011ddp.1_Intron	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	hypothetical protein LOC408263	66	Fibronectin type-III.					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAAGGGGCAAGATGTTCCAGC	0.547													0	0	0	0.00278	0	24	92										C	156770349	G	C	156770349	3	2	6	1	0	0	0	0	1	0	0	0	2299	942	33	1	482	1	C5orf40	5	156770349	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2439870	156770349	24144911	267	980										
C5orf54	63920	broad.mit.edu	37	chr5	159822236	159822236	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcttgtaataaagtatcctCatgagatgcaactccaaatg	7	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:159822236C>T	uc003lye.1	-	2	726	c.262G>A	c.(262-264)GAG>AAG	p.E88K	C5orf54_uc003lyf.1_Missense_Mutation_p.E88K	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	88										pancreas(1)	1						aaagtatcctcatgagatgca	0													0	0	0	0.01441	0	47	133										T	159822236	C	T	159822236	3	4	6	1	0	0	0	0	1	0	0	0	2310	835	29	1	1526	1	C5orf54	5	159822236	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3051887	159822236	21093024	268	981										
ODZ2	57451	broad.mit.edu	37	chr5	167553912	167553912	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agatggcaaatgtgaatgccGagagggctggaatggtgaac	16	5	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:167553912G>A	uc010jjd.2	+	12	2363	c.2363G>A	c.(2362-2364)CGA>CAA	p.R788Q	ODZ2_uc003lzr.3_Missense_Mutation_p.R556Q|ODZ2_uc003lzt.3_Missense_Mutation_p.R152Q|ODZ2_uc010jje.2_Missense_Mutation_p.R59Q|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGTGAATGCCGAGAGGGCTGG	0.532													0	0	0	0.009096	0	4	11										A	167553912	G	A	167553912	3	1	6	1	0	0	0	0	1	0	0	0	10835	1058	37	1	2409	1	ODZ2	5	167553912	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7731676	167553912	13361348	269	982										
RPL26L1	51121	broad.mit.edu	37	chr5	172386933	172386933	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaaaaccgcaaacgtcacttCaatgccccctcacacgtgcg	6	16	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:172386933C>T	uc003mcc.2	+	2	99	c.57C>T	c.(55-57)TTC>TTT	p.F19F	LOC100268168_uc011dfb.1_5'Flank|LOC100268168_uc011dfc.1_5'Flank	NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	19					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AACGTCACTTCAATGCCCCCT	0.567													0	0	0	0.01441	0	52	216										T	172386933	C	T	172386933	2	4	6	1	0	0	0	0	0	0	0	1	13574	825	29	1		1	RPL26L1	5	172386933	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4833021	172386933	8528327	270	983										
ZNF354C	30832	broad.mit.edu	37	chr5	178506267	178506267	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacaagtgtaatgaatgtgaGaaggcatttagcaacagttc	10	5	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr5:178506267G>T	uc003mju.2	+	5	949	c.834G>T	c.(832-834)GAG>GAT	p.E278D		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	278	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		ATGAATGTGAGAAGGCATTTA	0.403													1	0	2.09667e-21	0.003755	2.17397e-21	38	96										T	178506267	G	T	178506267	3	4	6	1	0	0	0	0	1	0	0	0	17863	933	33	3	848	3	ZNF354C	5	178506267	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6119334	178506267	2408993	271	984										
CDYL	9425	broad.mit.edu	37	chr6	4943860	4943860	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agccattggtctaggagcatCtatattgcctctttgcgatg	10	9	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:4943860C>G	uc003mwi.2	+	7	1495	c.1364C>G	c.(1363-1365)TCT>TGT	p.S455C	CDYL_uc003mwj.2_Missense_Mutation_p.S401C|CDYL_uc003mwk.2_Missense_Mutation_p.S166C|CDYL_uc011dhx.1_Missense_Mutation_p.S269C|CDYL_uc011dhy.1_Missense_Mutation_p.S269C	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	455					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CTAGGAGCATCTATATTGCCT	0.413													0	0	0	0.006999	0	35	136										G	4943860	C	G	4943860	3	3	6	1	0	0	0	0	1	0	0	0	3185	913	32	1	1220	1	CDYL	6	4943860	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		4943860	166171207	272	985										
RREB1	6239	broad.mit.edu	37	chr6	7231404	7231404	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atctactcctcagccctggtCagcagccctccactcgtggg	9	17	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:7231404C>T	uc003mxc.2	+	10	3462	c.3072C>T	c.(3070-3072)GTC>GTT	p.V1024V	RREB1_uc003mxb.2_Silent_p.V1024V|RREB1_uc010jnx.2_Silent_p.V1024V	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	1024	Pro-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CAGCCCTGGTCAGCAGCCCTC	0.706													0	0	0	0.00278	0	24	64										T	7231404	C	T	7231404	2	4	6	1	0	0	0	0	0	0	0	1	13679	813	29	1		1	RREB1	6	7231404	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2287544	7231404	163883663	273	986										
ZFP57	346171	broad.mit.edu	37	chr6	29641179	29641179	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcatcacagtaggtcttgtCacagagcgtgcaacagaagg	12	9	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:29641179C>T	uc011dlw.1	-	4	860	c.709G>A	c.(709-711)GAC>AAC	p.D237N	ZFP57_uc003nnl.3_Missense_Mutation_p.D217N	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	153	C2H2-type 3.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TAGGTCTTGTCACAGAGCGTG	0.572													0	0	0	0.005443	0	28	95										T	29641179	C	T	29641179	3	4	6	1	0	0	0	0	1	0	0	0	17648	826	29	1	905	1	ZFP57	6	29641179	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	22409775	29641179	141473888	274	987										
RNF39	80352	broad.mit.edu	37	chr6	30043478	30043478	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcccttctctccgactcccGcattaacttttgccgctttc	5	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:30043478G>A	uc003npe.2	-	1	151	c.89C>T	c.(88-90)GCG>GTG	p.A30V	RNF39_uc003npd.2_Missense_Mutation_p.A30V	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	30						cytoplasm	zinc ion binding				0						TCCGACTCCCGCATTAACTTT	0.607													0	0	0	0.008361	0	28	79										A	30043478	G	A	30043478	3	1	6	1	0	0	0	0	1	0	0	0	13491	1087	38	2	1189	2	RNF39	6	30043478	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	402299	30043478	141071589	275	988										
TRIM15	89870	broad.mit.edu	37	chr6	30139765	30139765	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggcttcccgggcttctcctCcgggcgccaccgctggcagg	15	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:30139765C>G	uc010jrx.2	+	7	1516	c.1037C>G	c.(1036-1038)TCC>TGC	p.S346C		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	346	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding				0						GGCTTCTCCTCCGGGCGCCAC	0.706													0	0	0	0.004672	0	2	5										G	30139765	C	G	30139765	3	3	6	1	0	0	0	0	1	0	0	0	16487	855	30	1	1063	1	TRIM15	6	30139765	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	96287	30139765	140975302	276	989										
MUC21	394263	broad.mit.edu	37	chr6	30954371	30954371	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacagccaccaactctgactCcagcacaacctccagtgggg	8	17	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:30954371C>G	uc003nsh.2	+	2	670	c.419C>G	c.(418-420)TCC>TGC	p.S140C	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	140	28 X 15 AA approximate tandem repeats.|Ser-rich.|8.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						AACTCTGACTCCAGCACAACC	0.607													0	0	0	0.01441	0	52	222										G	30954371	C	G	30954371	3	3	6	1	0	0	0	0	1	0	0	0	9977	855	30	1	425	1	MUC21	6	30954371	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	814606	30954371	140160696	277	990										
BAT3	7917	broad.mit.edu	37	chr6	31609349	31609349	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acatactcttctagccccgtGatcaatgtgtgggttgccat	9	11	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:31609349G>A	uc003nvg.3	-	17	2750	c.2436C>T	c.(2434-2436)ATC>ATT	p.I812I	BAT3_uc003nvf.3_Silent_p.I806I|BAT3_uc003nvh.3_Silent_p.I806I|BAT3_uc003nvi.3_Silent_p.I806I|BAT3_uc011dnw.1_Silent_p.I806I|BAT3_uc011dnx.1_Silent_p.I680I	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	812					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CTAGCCCCGTGATCAATGTGT	0.537													0	0	0	0.01441	0	62	112										A	31609349	G	A	31609349	2	1	6	1	0	0	0	0	0	0	0	1	1322	1280	45	1		1	BAT3	6	31609349	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	654978	31609349	139505718	278	991										
MSH5	4439	broad.mit.edu	37	chr6	31710892	31710892	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcctcccccacagcctcccaGgagcacagagagcctaaaag	8	17	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:31710892G>A	uc003nwv.1	+	5	439	c.360G>A	c.(358-360)CAG>CAA	p.Q120Q	MSH5_uc003nwt.1_Silent_p.Q120Q|MSH5_uc003nwu.1_Silent_p.Q120Q|MSH5_uc003nww.1_Silent_p.Q120Q|MSH5_uc003nwx.1_Silent_p.Q120Q|MSH5_uc011dof.1_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	120					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CAGCCTCCCAGGAGCACAGAG	0.488								Direct_reversal_of_damage|MMR					0	0	0	0.01441	0	82	103										A	31710892	G	A	31710892	2	1	6	1	0	0	0	0	0	0	0	1	9873	991	35	2		2	MSH5	6	31710892	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	101543	31710892	139404175	279	992										
C2	717	broad.mit.edu	37	chr6	31913003	31913003	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acccctgccttggctctgctGacaaaaactcccgcaaaagg	8	15	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:31913003G>A	uc003nyf.2	+	18	2392	c.2128G>A	c.(2128-2130)GAC>AAC	p.D710N	C2_uc011doo.1_Missense_Mutation_p.D464N|C2_uc011dop.1_Missense_Mutation_p.D496N|C2_uc010jtk.2_Missense_Mutation_p.D578N|C2_uc011doq.1_Missense_Mutation_p.D681N|C2_uc003nyg.2_Missense_Mutation_p.D487N|CFB_uc011dor.1_Intron|C2_uc003nyh.1_Silent_p.*344*|CFB_uc011dos.1_5'Flank|CFB_uc003nyi.2_5'Flank|CFB_uc003nyj.3_5'Flank	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	710	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		TGGCTCTGCTGACAAAAACTC	0.592													0	0	0	0.010818	0	32	103										A	31913003	G	A	31913003	3	1	6	1	0	0	0	0	1	0	0	0	2074	1290	45	1	2275	1	C2	6	31913003	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	202111	31913003	139202064	280	993										
ITPR3	3710	broad.mit.edu	37	chr6	33660624	33660624	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcgctgacctgcgtagtgaGaagcagaagaaggaggagat	15	6	0	5	rs149058562		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:33660624G>A	uc011drk.1	+	55	7797	c.7578G>A	c.(7576-7578)GAG>GAA	p.E2526E	ITPR3_uc003oey.2_Silent_p.E613E	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2526	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TGCGTAGTGAGAAGCAGAAGA	0.522													0	0	0	0.006999	0	41	64										A	33660624	G	A	33660624	2	1	6	1	0	0	0	0	0	0	0	1	7922	933	33	1		1	ITPR3	6	33660624	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1747621	33660624	137454443	281	994										
ITPR3	3710	broad.mit.edu	37	chr6	33661456	33661456	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaccgactacacgggccctGagagctacgtggcccagatg	13	13	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:33661456G>C	uc011drk.1	+	56	7978	c.7759G>C	c.(7759-7761)GAG>CAG	p.E2587Q	ITPR3_uc003oey.2_Missense_Mutation_p.E674Q	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	2587	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CACGGGCCCTGAGAGCTACGT	0.552													0	0	0	0.008871	0	18	25										C	33661456	G	C	33661456	3	2	6	1	0	0	0	0	1	0	0	0	7922	1291	45	1	7981	1	ITPR3	6	33661456	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	832	33661456	137453611	282	995										
C6orf222	389384	broad.mit.edu	37	chr6	36298201	36298201	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttggtgtcttgcgaaggcctCtgctcgctggggagaaaatc	14	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:36298201C>G	uc003oly.2	-	2	445	c.267G>C	c.(265-267)CAG>CAC	p.Q89H		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	89										skin(2)|ovary(1)|breast(1)	4						GCGAAGGCCTCTGCTCGCTGG	0.617													0	0	0	0.004289	0	34	121										G	36298201	C	G	36298201	3	3	6	1	0	0	0	0	1	0	0	0	2356	912	32	1	1735	1	C6orf222	6	36298201	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2636745	36298201	134816866	283	996										
PI16	221476	broad.mit.edu	37	chr6	36930731	36930731	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aacccatcggaagcccggaaGatgctcaggatttgccttac	10	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:36930731G>A	uc003ona.2	+	5	941	c.613G>A	c.(613-615)GAT>AAT	p.D205N	PI16_uc003omz.1_Missense_Mutation_p.D205N|PI16_uc003onb.2_Missense_Mutation_p.D205N|PI16_uc011dts.1_5'UTR	NM_153370	NP_699201	Q6UXB8	PI16_HUMAN	protease inhibitor 16 precursor	205	Extracellular (Potential).					extracellular region|integral to membrane	peptidase inhibitor activity				0						AAGCCCGGAAGATGCTCAGGA	0.542													0	0	0	0.003954	0	25	55										A	36930731	G	A	36930731	3	1	6	1	0	0	0	0	1	0	0	0	11869	942	33	1	631	1	PI16	6	36930731	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	632530	36930731	134184336	284	997										
MDGA1	266727	broad.mit.edu	37	chr6	37620068	37620068	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcccagctggatgttctcaCtctctttgatcacgtcagga	10	12	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:37620068C>T	uc003onu.1	-	7	2210	c.1031G>A	c.(1030-1032)AGT>AAT	p.S344N	MDGA1_uc003onw.3_RNA	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	344	Ig-like 4.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						GATGTTCTCACTCTCTTTGAT	0.567													0	0	0	0.004007	0	15	37										T	37620068	C	T	37620068	3	4	6	1	0	0	0	0	1	0	0	0	9406	565	20	2	1880	2	MDGA1	6	37620068	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	689337	37620068	133494999	285	998										
DNAH8	1769	broad.mit.edu	37	chr6	38834581	38834581	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aacttgcaagctgtggttttCttgaaaatgttatcttggct	9	6	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:38834581C>G	uc003ooe.1	+	45	6571	c.5971C>G	c.(5971-5973)CTT>GTT	p.L1991V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CTGTGGTTTTCTTGAAAATGT	0.308													0	0	0	0.00308	0	7	62										G	38834581	C	G	38834581	3	3	6	1	0	0	0	0	1	0	0	0	4607	913	32	1	6141	1	DNAH8	6	38834581	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1214513	38834581	132280486	286	999										
DNAH8	1769	broad.mit.edu	37	chr6	38881670	38881670	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgaatctgttgctaaactctCtcaggatcttgcagtcaagg	9	9	5	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:38881670C>T	uc003ooe.1	+	65	9854	c.9254C>T	c.(9253-9255)TCT>TTT	p.S3085F	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GCTAAACTCTCTCAGGATCTT	0.368													0	0	0	0.005443	0	20	53										T	38881670	C	T	38881670	3	4	6	1	0	0	0	0	1	0	0	0	4607	913	32	1	9504	1	DNAH8	6	38881670	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	47089	38881670	132233397	287	1000										
DNAH8	1769	broad.mit.edu	37	chr6	38957823	38957823	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagatgtttgaaccgtcattCtgcttttatactggatataa	7	6	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:38957823C>T	uc003ooe.1	+	86	13038	c.12438C>T	c.(12436-12438)TTC>TTT	p.F4146F		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AACCGTCATTCTGCTTTTATA	0.363													0	0	0	0.004289	0	37	149										T	38957823	C	T	38957823	2	4	6	1	0	0	0	0	0	0	0	1	4607	912	32	1		1	DNAH8	6	38957823	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	76153	38957823	132157244	288	1001										
PTK7	5754	broad.mit.edu	37	chr6	43114421	43114421	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaattgaagtcacagcccctCagcaccaagcagaaggtgag	10	11	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:43114421C>T	uc003oub.1	+	17	2904	c.2706C>T	c.(2704-2706)CTC>CTT	p.L902L	PTK7_uc003ouc.1_Silent_p.L846L|PTK7_uc003oud.1_Silent_p.L862L|PTK7_uc003oue.1_Silent_p.L772L|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.L910L|PTK7_uc010jyj.1_Silent_p.L228L	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	902	Cytoplasmic (Potential).|Protein kinase; inactive.|Interaction with CTNNB1.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CACAGCCCCTCAGCACCAAGC	0.488													0	0	0	0.003163	0	14	71										T	43114421	C	T	43114421	2	4	6	1	0	0	0	0	0	0	0	1	12765	813	29	1		1	PTK7	6	43114421	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4156598	43114421	128000646	289	1002										
SPATS1	221409	broad.mit.edu	37	chr6	44310891	44310891	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgccgtctcccctccatctCaagcacgacctgcggcagac	8	19	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:44310891C>G	uc003oxk.2	+	1	406	c.59C>G	c.(58-60)TCA>TGA	p.S20*	SPATS1_uc003oxg.2_Intron|SPATS1_uc010jzb.2_5'UTR	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	20										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCCTCCATCTCAAGCACGACC	0.512													0	0	0	0.003163	0	16	72										G	44310891	C	G	44310891	4	3	6	1	0	0	0	0	0	1	0	0	15017	838	29	1	61	1	SPATS1	6	44310891	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1196470	44310891	126804176	290	1003										
PKHD1	5314	broad.mit.edu	37	chr6	51929769	51929769	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttacctggctgaggggtggtGagcctcacatcttttcctgg	13	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:51929769G>A	uc003pah.1	-	13	1236	c.960C>T	c.(958-960)CTC>CTT	p.L320L	PKHD1_uc003pai.2_Silent_p.L320L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	320	IPT/TIG 3.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GAGGGGTGGTGAGCCTCACAT	0.448													0	0	0	0.00632	0	27	112										A	51929769	G	A	51929769	2	1	6	1	0	0	0	0	0	0	0	1	11971	1277	45	1		1	PKHD1	6	51929769	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7618878	51929769	119185298	291	1004										
RIMS1	22999	broad.mit.edu	37	chr6	72957721	72957721	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttttttctcattttaggttCaagttcctttgaatctcaga	5	7	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:72957721C>T	uc003pga.2	+	12	2209	c.2132C>T	c.(2131-2133)TCA>TTA	p.S711L	RIMS1_uc011dyb.1_Missense_Mutation_p.S337L|RIMS1_uc003pgc.2_Missense_Mutation_p.S337L|RIMS1_uc010kaq.2_Missense_Mutation_p.S185L|RIMS1_uc011dyc.1_Missense_Mutation_p.S185L|RIMS1_uc010kar.2_Missense_Mutation_p.S104L|RIMS1_uc011dyd.1_Missense_Mutation_p.S170L|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.S337L|RIMS1_uc010kas.1_Missense_Mutation_p.S170L	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	711					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ATTTTAGGTTCAAGTTCCTTT	0.318													0	0	0	0.014323	0	23	93										T	72957721	C	T	72957721	3	4	6	1	0	0	0	0	1	0	0	0	13367	838	29	1	2341	1	RIMS1	6	72957721	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	21027952	72957721	98157346	292	1005										
KCNQ5	56479	broad.mit.edu	37	chr6	73900420	73900420	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtgtagaattaaaagccttCaaacacggtaagcaatggaa	9	6	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:73900420C>G	uc003pgk.2	+	12	2049	c.1702C>G	c.(1702-1704)CAA>GAA	p.Q568E	KCNQ5_uc011dyh.1_Missense_Mutation_p.Q587E|KCNQ5_uc011dyi.1_Missense_Mutation_p.Q578E|KCNQ5_uc010kat.2_Missense_Mutation_p.Q559E|KCNQ5_uc011dyj.1_Missense_Mutation_p.Q458E|KCNQ5_uc011dyk.1_Missense_Mutation_p.Q318E	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	568					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TAAAAGCCTTCAAACACGGTA	0.373													0	0	0	0.00632	0	23	82										G	73900420	C	G	73900420	3	3	6	1	0	0	0	0	1	0	0	0	8086	827	29	1	1809	1	KCNQ5	6	73900420	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	942699	73900420	97214647	293	1006										
CD109	135228	broad.mit.edu	37	chr6	74533302	74533302	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggctcccatcatcactcttCagtcatttttattttctgtt	4	11	6	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:74533302C>T	uc003php.2	+	33	4708	c.4283C>T	c.(4282-4284)TCA>TTA	p.S1428L	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.S1411L|CD109_uc010kba.2_Missense_Mutation_p.S1351L	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	1428						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						CATCACTCTTCAGTCATTTTT	0.428													0	0	0	0.008361	0	31	123										T	74533302	C	T	74533302	3	4	6	1	0	0	0	0	1	0	0	0	2963	838	29	1	4413	1	CD109	6	74533302	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	632882	74533302	96581765	294	1007										
CNR1	1268	broad.mit.edu	37	chr6	88854856	88854856	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaggaagttaaagggaatttCtgtgggaagtaccctaattt	11	4	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:88854856C>G	uc011dzq.1	-	2	3701	c.138G>C	c.(136-138)CAG>CAC	p.Q46H	CNR1_uc010kbz.2_Missense_Mutation_p.Q46H|CNR1_uc011dzr.1_Missense_Mutation_p.Q46H|CNR1_uc011dzs.1_Missense_Mutation_p.Q46H|CNR1_uc003pmq.3_Missense_Mutation_p.Q46H|CNR1_uc011dzt.1_Missense_Mutation_p.Q46H|CNR1_uc010kca.2_Intron	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	46	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	AAGGGAATTTCTGTGGGAAGT	0.498													0	0	0	0.003271	0	37	94										G	88854856	C	G	88854856	3	3	6	1	0	0	0	0	1	0	0	0	3631	912	32	1	1284	1	CNR1	6	88854856	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	14321554	88854856	82260211	295	1008										
CASP8AP2	9994	broad.mit.edu	37	chr6	90576217	90576217	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacaatttcacagaattattGagtcagcaattttgagtttt	6	5	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:90576217G>C	uc003pnr.2	+	8	3404	c.3208G>C	c.(3208-3210)GAG>CAG	p.E1070Q	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1070Q|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1070Q	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1070					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CAGAATTATTGAGTCAGCAAT	0.274													0	0	0	0.004672	0	2	5										C	90576217	G	C	90576217	3	2	6	1	0	0	0	0	1	0	0	0	2678	1291	45	1	3234	1	CASP8AP2	6	90576217	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1721361	90576217	80538850	296	1009										
FRK	2444	broad.mit.edu	37	chr6	116264315	116264315	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttcaccggcagctttatttCgtgtctagattcatagatgt	8	9	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:116264315C>T	uc003pwi.1	-	7	1621	c.1174G>A	c.(1174-1176)GAA>AAA	p.E392K		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	392	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		AGCTTTATTTCGTGTCTAGAT	0.378													0	0	0	0.012319	0	18	52										T	116264315	C	T	116264315	3	4	6	1	0	0	0	0	1	0	0	0	6048	893	31	1	351	1	FRK	6	116264315	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	25688098	116264315	54850752	297	1010										
ROS1	6098	broad.mit.edu	37	chr6	117718277	117718277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatcaaaggtgcagtttcagGaactggaagagataatggtg	13	4	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:117718277G>A	uc003pxp.1	-	7	779	c.580C>T	c.(580-582)CCT>TCT	p.P194S	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	194	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCAGTTTCAGGAACTGGAAGA	0.388			T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.010504	0	22	86										A	117718277	G	A	117718277	3	1	6	1	0	0	0	0	1	0	0	0	13531	1174	41	1	6611	1	ROS1	6	117718277	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1453962	117718277	53396790	298	1011										
SMPDL3A	10924	broad.mit.edu	37	chr6	123127407	123127407	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taaattctttgtttgtggctCctgctgttacaccagtgaag	9	8	1	1	rs143627205		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:123127407C>G	uc003pzg.2	+	7	1470	c.949C>G	c.(949-951)CCT>GCT	p.P317A	SMPDL3A_uc003pzh.2_Missense_Mutation_p.P186A	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	317					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		GTTTGTGGCTCCTGCTGTTAC	0.313													0	0	0	0.00499	0	12	42										G	123127407	C	G	123127407	3	3	6	1	0	0	0	0	1	0	0	0	14808	855	30	1	975	1	SMPDL3A	6	123127407	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5409130	123127407	47987660	299	1012										
TRMT11	60487	broad.mit.edu	37	chr6	126320719	126320719	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atggctaaccatggaaaagtGaaagaaaatgatattgtctt	9	4	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:126320719G>A	uc003qam.2	+	7	760	c.639G>A	c.(637-639)GTG>GTA	p.V213V	TRMT11_uc003qan.2_RNA|TRMT11_uc010kev.2_Silent_p.V213V	NM_001031712	NP_001026882	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11	213					tRNA processing		methyltransferase activity|nucleic acid binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0356)		ATGGAAAAGTGAAAGAAAATG	0.313													0	0	0	0.00333	0	26	81										A	126320719	G	A	126320719	2	1	6	1	0	0	0	0	0	0	0	1	16559	1277	45	1		1	TRMT11	6	126320719	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3193312	126320719	44794348	300	1013										
TCF21	6943	broad.mit.edu	37	chr6	134210742	134210742	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cccaccaagaagagccccctGagcggggtcagccaggaggg	15	14	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:134210742G>A	uc003qei.3	+	1	483	c.207G>A	c.(205-207)CTG>CTA	p.L69L	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Silent_p.L69L	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	69					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		AGAGCCCCCTGAGCGGGGTCA	0.682													0	0	0	0.000602	0	5	63										A	134210742	G	A	134210742	2	1	6	1	0	0	0	0	0	0	0	1	15688	1277	45	1		1	TCF21	6	134210742	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7890023	134210742	36904325	301	1014										
SYNE1	23345	broad.mit.edu	37	chr6	152461256	152461256	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcatcctcaactccttgctCaatgcctgggcctggagaag	9	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:152461256C>G	uc010kiw.2	-	140	25889	c.25287G>C	c.(25285-25287)TTG>TTC	p.L8429F	SYNE1_uc010kiv.2_Missense_Mutation_p.L2953F|SYNE1_uc003qos.3_Missense_Mutation_p.L2953F|SYNE1_uc003qot.3_Missense_Mutation_p.L8381F|SYNE1_uc003qou.3_Missense_Mutation_p.L8429F|SYNE1_uc003qop.3_Missense_Mutation_p.L614F|SYNE1_uc011eez.1_Missense_Mutation_p.L631F|SYNE1_uc003qoq.3_Missense_Mutation_p.L631F|SYNE1_uc003qor.3_Missense_Mutation_p.L1352F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8429	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTCCTTGCTCAATGCCTGGG	0.502										HNSCC(10;0.0054)			0	0	0	0.003755	0	33	125										G	152461256	C	G	152461256	3	3	6	1	0	0	0	0	1	0	0	0	15442	825	29	1	1134	1	SYNE1	6	152461256	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	18250514	152461256	18653811	302	1015										
TULP4	56995	broad.mit.edu	37	chr6	158834155	158834155	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggccacgtgcgatgcggacgGaggcatattcgtgtggattc	16	9	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:158834155G>A	uc003qrf.2	+	2	1668	c.311G>A	c.(310-312)GGA>GAA	p.G104E	TULP4_uc011efo.1_Missense_Mutation_p.G104E|TULP4_uc003qrg.2_Missense_Mutation_p.G104E	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	104	WD 1.				intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GATGCGGACGGAGGCATATTC	0.562													0	0	0	0.003163	0	14	33										A	158834155	G	A	158834155	3	1	6	1	0	0	0	0	1	0	0	0	16773	1174	41	1	317	1	TULP4	6	158834155	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6372899	158834155	12280912	303	1016										
T	6862	broad.mit.edu	37	chr6	166571975	166571975	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggggtgtgtagtgcgcggggGagccccggaagaactgggcc	21	9	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:166571975G>C	uc003quu.1	-	9	1629	c.1136C>G	c.(1135-1137)TCC>TGC	p.S379C	T_uc003qut.1_Missense_Mutation_p.S380C|T_uc003quv.1_Missense_Mutation_p.S321C	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	379					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GTGCGCGGGGGAGCCCCGGAA	0.706									Chordoma_Familial_Clustering_of				0	0	0	0.00499	0	13	55										C	166571975	G	C	166571975	3	2	6	1	0	0	0	0	1	0	0	0	15485	1174	41	1	175	1	T	6	166571975	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7737820	166571975	4543092	304	1017										
MLLT4	4301	broad.mit.edu	37	chr6	168344641	168344641	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcggcagaactcatgacaaGaacaagctctgtggtgacac	12	10	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr6:168344641G>C	uc003qwd.2	+	25	3378	c.3236G>C	c.(3235-3237)AGA>ACA	p.R1079T	MLLT4_uc003qwb.1_Missense_Mutation_p.R1064T|MLLT4_uc003qwc.1_Missense_Mutation_p.R1080T|MLLT4_uc003qwg.1_Missense_Mutation_p.R389T	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1080	PDZ.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CTCATGACAAGAACAAGCTCT	0.488			T	MLL	AL								0	0	0	0.004656	0	27	66										C	168344641	G	C	168344641	3	2	6	1	0	0	0	0	1	0	0	0	9629	942	33	1	3337	1	MLLT4	6	168344641	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1772666	168344641	2770426	305	1018										
LFNG	3955	broad.mit.edu	37	chr7	2565989	2565989	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcatccgcagcggcctcttCcactcccacctggagaacct	7	19	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:2565989C>G	uc003smf.2	+	6	950	c.933C>G	c.(931-933)TTC>TTG	p.F311L	LFNG_uc003smg.2_Missense_Mutation_p.F311L	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	311	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		GCGGCCTCTTCCACTCCCACC	0.657													0	0	0	0.010818	0	34	96										G	2565989	C	G	2565989	3	3	6	1	0	0	0	0	1	0	0	0	8737	854	30	1	1231	1	LFNG	7	2565989	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		2565989	156572674	306	1019										
KIAA0415	9907	broad.mit.edu	37	chr7	4830468	4830468	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccccaggtggtcaccgtgctGatgaccacgctgacgaagct	12	14	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:4830468G>C	uc003sne.2	+	16	2186	c.2103G>C	c.(2101-2103)CTG>CTC	p.L701L	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Silent_p.L178L	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	701					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		TCACCGTGCTGATGACCACGC	0.647													0	0	0	0.004672	0	2	12										C	4830468	G	C	4830468	2	2	6	1	0	0	0	0	0	0	0	1	8175	1277	45	1		1	KIAA0415	7	4830468	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2264479	4830468	154308195	307	1020										
USP42	84132	broad.mit.edu	37	chr7	6180583	6180583	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agggcgtttcagatacttttGatccatatcttgatataaca	7	7	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:6180583G>C	uc011jwo.1	+	7	886	c.763G>C	c.(763-765)GAT>CAT	p.D255H	USP42_uc011jwn.1_Missense_Mutation_p.D100H|USP42_uc010kth.1_Missense_Mutation_p.D188H|USP42_uc011jwp.1_Missense_Mutation_p.D255H|USP42_uc011jwq.1_Missense_Mutation_p.D62H|USP42_uc011jwr.1_Missense_Mutation_p.D100H	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	255					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		AGATACTTTTGATCCATATCT	0.264													0	0	0	0.004482	0	9	48										C	6180583	G	C	6180583	3	2	6	1	0	0	0	0	1	0	0	0	17070	1290	45	1	785	1	USP42	7	6180583	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1350115	6180583	152958080	308	1021										
COL28A1	340267	broad.mit.edu	37	chr7	7413118	7413118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttctctggccccacgctttCtgagctgtcgatcacaaaca	8	14	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:7413118C>G	uc003src.1	-	32	2536	c.2419G>C	c.(2419-2421)GAA>CAA	p.E807Q	COL28A1_uc011jxe.1_Missense_Mutation_p.E490Q	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	807	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CCCACGCTTTCTGAGCTGTCG	0.463													0	0	0	0.006999	0	41	134										G	7413118	C	G	7413118	3	3	6	1	0	0	0	0	1	0	0	0	3686	922	32	1	974	1	COL28A1	7	7413118	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1232535	7413118	151725545	309	1022										
FAM188B	84182	broad.mit.edu	37	chr7	30876370	30876370	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcaaaaccaattgacctctCagtagcaaaggtaagtgtaa	7	8	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:30876370C>T	uc003tbt.2	+	7	1306	c.1229C>T	c.(1228-1230)TCA>TTA	p.S410L	FAM188B_uc010kwe.2_Missense_Mutation_p.S381L	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	410											0						ATTGACCTCTCAGTAGCAAAG	0.463													0	0	0	0.007291	0	29	128										T	30876370	C	T	30876370	3	4	6	1	0	0	0	0	1	0	0	0	5515	838	29	1	1255	1	FAM188B	7	30876370	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	23463252	30876370	128262293	310	1023										
POLD2	5425	broad.mit.edu	37	chr7	44157622	44157622	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caccacacagcacttctcctCaggctgcagttcacacagct	6	17	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:44157622C>T	uc010kxz.2	-	4	912	c.262G>A	c.(262-264)GAG>AAG	p.E88K	POLD2_uc003tke.3_Missense_Mutation_p.E88K|POLD2_uc010kya.2_Missense_Mutation_p.E88K|POLD2_uc003tkf.3_Missense_Mutation_p.E88K	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	88					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						CACTTCTCCTCAGGCTGCAGT	0.622													0	0	0	0.003954	0	25	93										T	44157622	C	T	44157622	3	4	6	1	0	0	0	0	1	0	0	0	12191	835	29	1	1183	1	POLD2	7	44157622	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	13281252	44157622	114981041	311	1024										
OGDH	4967	broad.mit.edu	37	chr7	44747299	44747299	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctatgactacgtgaagccaaGacttcggaccaccatcagcc	8	14	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:44747299G>C	uc003tln.2	+	22	3024	c.2915G>C	c.(2914-2916)AGA>ACA	p.R972T	OGDH_uc011kbx.1_Missense_Mutation_p.R968T|OGDH_uc011kby.1_Missense_Mutation_p.R822T|OGDH_uc003tlp.2_Missense_Mutation_p.R983T|OGDH_uc011kbz.1_Missense_Mutation_p.R767T	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	972					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GTGAAGCCAAGACTTCGGACC	0.602													0	0	0	0.012319	0	23	90										C	44747299	G	C	44747299	3	2	6	1	0	0	0	0	1	0	0	0	10839	942	33	1	3170	1	OGDH	7	44747299	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	589677	44747299	114391364	312	1025										
MAGI2	9863	broad.mit.edu	37	chr7	77885556	77885556	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cattgtcatcatggacgggcGgtggatacgtgccgtctagc	14	10	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:77885556G>A	uc003ugx.2	-	10	2005	c.1751C>T	c.(1750-1752)CCG>CTG	p.P584L	MAGI2_uc003ugy.2_Missense_Mutation_p.P584L|MAGI2_uc010ldx.1_Missense_Mutation_p.P193L|MAGI2_uc010ldy.1_Missense_Mutation_p.P193L|MAGI2_uc011kgr.1_Missense_Mutation_p.P416L|MAGI2_uc011kgs.1_Missense_Mutation_p.P421L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	584						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ATGGACGGGCGGTGGATACGT	0.527													0	0	0	0.004482	0	7	53										A	77885556	G	A	77885556	3	1	6	1	0	0	0	0	1	0	0	0	9191	1116	39	2	2668	2	MAGI2	7	77885556	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	33138257	77885556	81253107	313	1026										
PCLO	27445	broad.mit.edu	37	chr7	82585375	82585375	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcaaatgcttcatcgtcttCatcatgccatgagtgacgtc	7	11	5	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:82585375C>T	uc003uhx.2	-	5	5183	c.4894G>A	c.(4894-4896)GAA>AAA	p.E1632K	PCLO_uc003uhv.2_Missense_Mutation_p.E1632K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1563					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCATCGTCTTCATCATGCCAT	0.428													0	0	0	0.00632	0	25	396										T	82585375	C	T	82585375	3	4	6	1	0	0	0	0	1	0	0	0	11583	835	29	1	10635	1	PCLO	7	82585375	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4699819	82585375	76553288	314	1027										
PPP1R9A	55607	broad.mit.edu	37	chr7	94919406	94919406	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgtgtttctttcttaggctCttggaatgacagcatcccag	10	9	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:94919406C>G	uc003unp.2	+	16	3370	c.3088C>G	c.(3088-3090)CTT>GTT	p.L1030V	PPP1R9A_uc010lfj.2_Missense_Mutation_p.L1306V|PPP1R9A_uc011kif.1_Missense_Mutation_p.L1228V|PPP1R9A_uc003unq.2_Missense_Mutation_p.L1185V|PPP1R9A_uc011kig.1_Missense_Mutation_p.L1022V|PPP1R9A_uc003unr.2_Missense_Mutation_p.L319V	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	1030	Interacts with TGN38 (By similarity).|SAM.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TTCTTAGGCTCTTGGAATGAC	0.413										HNSCC(28;0.073)			0	0	0	0.008291	0	10	41										G	94919406	C	G	94919406	3	3	6	1	0	0	0	0	1	0	0	0	12378	913	32	1	4018	1	PPP1R9A	7	94919406	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	12334031	94919406	64219257	315	1028										
TAC1	6863	broad.mit.edu	37	chr7	97362036	97362036	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtccgactggtacgacagcGaccagatcaaggtgaggccc	14	12	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:97362036G>T	uc003uop.3	+	2	358	c.112G>T	c.(112-114)GAC>TAC	p.D38Y	TAC1_uc003uoq.3_Missense_Mutation_p.D38Y|TAC1_uc003uor.3_Missense_Mutation_p.D38Y|TAC1_uc003uos.3_Missense_Mutation_p.D38Y	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	38					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	GTACGACAGCGACCAGATCAA	0.557													1	0	1.1804e-14	0.003954	1.22119e-14	24	69										T	97362036	G	T	97362036	3	4	6	1	0	0	0	0	1	0	0	0	15495	1058	37	3	114	3	TAC1	7	97362036	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2442630	97362036	61776627	316	1029										
ZNF655	79027	broad.mit.edu	37	chr7	99170257	99170257	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attcagcctctggtaaacatGaacacttaaatctaacagag	6	9	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:99170257G>A	uc003urh.2	+	3	919	c.526G>A	c.(526-528)GAA>AAA	p.E176K	ZNF655_uc010lga.2_Missense_Mutation_p.E211K|ZNF655_uc010lgc.2_Missense_Mutation_p.E211K|ZNF655_uc003urj.2_Missense_Mutation_p.E176K|ZNF655_uc003urk.2_Missense_Mutation_p.E13K|ZNF655_uc010lgd.2_Missense_Mutation_p.E13K	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	176					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					TGGTAAACATGAACACTTAAA	0.378													0	0	0	0.004482	0	9	57										A	99170257	G	A	99170257	3	1	6	1	0	0	0	0	1	0	0	0	18065	1291	45	1	1063	1	ZNF655	7	99170257	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1808221	99170257	59968406	317	1030			1	3		4	4	674	G		7.048915e-07
ZNF655	79027	broad.mit.edu	37	chr7	99170385	99170385	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tataaatgtgatgtatgtggGaaaattttccatcagagctc	9	5	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:99170385G>A	uc003urh.2	+	3	1047	c.654G>A	c.(652-654)GGG>GGA	p.G218G	ZNF655_uc010lga.2_Silent_p.G253G|ZNF655_uc010lgc.2_Silent_p.G253G|ZNF655_uc003urj.2_Silent_p.G218G|ZNF655_uc003urk.2_Silent_p.G55G|ZNF655_uc010lgd.2_Silent_p.G55G	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	218	C2H2-type 1.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					ATGTATGTGGGAAAATTTTCC	0.388													0	0	0	0.003163	0	16	46										A	99170385	G	A	99170385	2	1	6	1	0	0	0	0	0	0	0	1	18065	1161	41	1		1	ZNF655	7	99170385	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	128	99170385	59968278	318	1031			1	3		4	4	674	G		7.048915e-07
ZNF655	79027	broad.mit.edu	37	chr7	99170442	99170442	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagagaatccatactagagaGaagccctacaaatgtaaaga	8	8	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:99170442G>A	uc003urh.2	+	3	1104	c.711G>A	c.(709-711)GAG>GAA	p.E237E	ZNF655_uc010lga.2_Silent_p.E272E|ZNF655_uc010lgc.2_Silent_p.E272E|ZNF655_uc003urj.2_Silent_p.E237E|ZNF655_uc003urk.2_Silent_p.E74E|ZNF655_uc010lgd.2_Silent_p.E74E	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	237					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					ATACTAGAGAGAAGCCCTACA	0.378													0	0	0	0.004482	0	9	52										A	99170442	G	A	99170442	2	1	6	1	0	0	0	0	0	0	0	1	18065	933	33	1		1	ZNF655	7	99170442	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	57	99170442	59968221	319	1032			1	3		4	4	674	G		7.048915e-07
ZNF655	79027	broad.mit.edu	37	chr7	99170930	99170930	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acatcttattcagcatcaaaGaattcacacaggagagaaag	7	8	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:99170930G>C	uc003urh.2	+	3	1592	c.1199G>C	c.(1198-1200)AGA>ACA	p.R400T	ZNF655_uc010lga.2_Missense_Mutation_p.R435T|ZNF655_uc010lgc.2_Missense_Mutation_p.R435T|ZNF655_uc003urj.2_Missense_Mutation_p.R400T|ZNF655_uc003urk.2_Missense_Mutation_p.R237T|ZNF655_uc010lgd.2_Missense_Mutation_p.R237T	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	400	C2H2-type 5.				G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CAGCATCAAAGAATTCACACA	0.353													0	0	0	0.014323	0	23	72										C	99170930	G	C	99170930	3	2	6	1	0	0	0	0	1	0	0	0	18065	942	33	1	1736	1	ZNF655	7	99170930	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	488	99170930	59967733	320	1033			1	3		4	4	674	G		7.048915e-07
MUC17	140453	broad.mit.edu	37	chr7	100695124	100695124	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaggaatatggagactacttCgtagtggagtaccgggacca	13	7	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:100695124C>T	uc003uxp.1	+	9	13037	c.12984C>T	c.(12982-12984)TTC>TTT	p.F4328F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4328	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAGACTACTTCGTAGTGGAGT	0.587													0	0	0	0.00623	0	41	116										T	100695124	C	T	100695124	2	4	6	1	0	0	0	0	0	0	0	1	9974	883	31	1		1	MUC17	7	100695124	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1524194	100695124	58443539	321	1034										
CUX1	1523	broad.mit.edu	37	chr7	101845024	101845024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtgaaaaatgaggtgggccGcagcggtgcctggaaggacc	18	8	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:101845024G>A	uc003uyx.3	+	18	2485	c.2447G>A	c.(2446-2448)CGC>CAC	p.R816H	CUX1_uc003uys.3_Missense_Mutation_p.R827H|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	816					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GAGGTGGGCCGCAGCGGTGCC	0.672													0	0	0	0.008291	0	11	18										A	101845024	G	A	101845024	3	1	6	1	0	0	0	0	1	0	0	0	4064	1087	38	2	2584	2	CUX1	7	101845024	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1149900	101845024	57293639	322	1035										
PMPCB	9512	broad.mit.edu	37	chr7	102940661	102940661	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cccagttagatctggaacttGagattgaaaatatgggtgct	11	6	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:102940661G>C	uc003vbl.2	+	4	398	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	PMPCB_uc010liu.1_Missense_Mutation_p.E122Q|PMPCB_uc003vbk.1_Missense_Mutation_p.E122Q|PMPCB_uc003vbm.2_Missense_Mutation_p.E31Q|PMPCB_uc010liv.2_Missense_Mutation_p.E28Q|PMPCB_uc010liw.2_Missense_Mutation_p.E31Q|PMPCB_uc011kll.1_Missense_Mutation_p.E17Q|PMPCB_uc011klm.1_5'UTR	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	122					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						TCTGGAACTTGAGATTGAAAA	0.388													0	0	0	0.010818	0	31	157										C	102940661	G	C	102940661	3	2	6	1	0	0	0	0	1	0	0	0	12141	1291	45	1	378	1	PMPCB	7	102940661	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1095637	102940661	56198002	323	1036										
BCAP29	55973	broad.mit.edu	37	chr7	107253828	107253828	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatgaagatgcagtcagagaGactttcgaaagaatatgatc	10	5	1	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:107253828G>C	uc003vej.2	+	7	980	c.641G>C	c.(640-642)AGA>ACA	p.R214T	BCAP29_uc011kly.1_Missense_Mutation_p.R120T|BCAP29_uc011klz.1_Missense_Mutation_p.R214T|BCAP29_uc011kma.1_Missense_Mutation_p.R214T	NM_018844	NP_061332	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein BAP29 isoform	214	Cytoplasmic (Potential).				apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				large_intestine(1)|ovary(1)	2						CAGTCAGAGAGACTTTCGAAA	0.313													0	0	0	0.013537	0	11	41										C	107253828	G	C	107253828	3	2	6	1	0	0	0	0	1	0	0	0	1346	942	33	1	663	1	BCAP29	7	107253828	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4313167	107253828	51884835	324	1037										
IFRD1	3475	broad.mit.edu	37	chr7	112096062	112096062	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tatattatttcttaggaccaGaagtccttgatgaggaagga	10	5	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:112096062G>A	uc003vgh.2	+	4	648	c.205G>A	c.(205-207)GAA>AAA	p.E69K	IFRD1_uc011kmn.1_Missense_Mutation_p.E19K|IFRD1_uc003vgi.2_Missense_Mutation_p.E69K|IFRD1_uc003vgj.2_Missense_Mutation_p.E69K|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.E19K	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	69					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						CTTAGGACCAGAAGTCCTTGA	0.368													0	0	0	0.010729	0	9	53										A	112096062	G	A	112096062	3	1	6	1	0	0	0	0	1	0	0	0	7553	943	33	1	215	1	IFRD1	7	112096062	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4842234	112096062	47042601	325	1038										
WASL	8976	broad.mit.edu	37	chr7	123332847	123332847	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcttcccctagcaggaggagGaggaggacctgagttgtgtg	16	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:123332847G>C	uc003vkz.2	-	9	1229	c.901C>G	c.(901-903)CCT>GCT	p.P301A		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	301	Pro-rich.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						gcaggaggaggaggaggacct	0.428													0	0	0	0.010818	0	32	89										C	123332847	G	C	123332847	3	2	6	1	0	0	0	0	1	0	0	0	17253	1174	41	1	628	1	WASL	7	123332847	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11236785	123332847	35805816	326	1039										
SND1	27044	broad.mit.edu	37	chr7	127714730	127714730	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gccgaggaggccgcaaagcaGaagaaagagaaggtacatgt	15	7	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:127714730G>A	uc003vmi.2	+	17	2182	c.1956G>A	c.(1954-1956)CAG>CAA	p.Q652Q	SND1_uc010lle.2_Silent_p.Q305Q	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	652	TNase-like 4.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CCGCAAAGCAGAAGAAAGAGA	0.602													0	0	0	0.009096	0	4	23										A	127714730	G	A	127714730	2	1	6	1	0	0	0	0	0	0	0	1	14844	933	33	1		1	SND1	7	127714730	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4381883	127714730	31423933	327	1040										
CHCHD3	54927	broad.mit.edu	37	chr7	132754904	132754904	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attaaaattcagcaatacctGaggcaccataagcaccagaa	6	10	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:132754904G>C	uc003vre.2	-	2	303	c.167C>G	c.(166-168)TCA>TGA	p.S56*	CHCHD3_uc010lmi.2_RNA|CHCHD3_uc003vrf.2_Nonsense_Mutation_p.S56*|CHCHD3_uc010lmj.2_Intron|CHCHD3_uc011kpn.1_Nonsense_Mutation_p.S56*	NM_017812	NP_060282	Q9NX63	CHCH3_HUMAN	coiled-coil-helix-coiled-coil-helix domain	56					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0						AGCAATACCTGAGGCACCATA	0.378													0	0	0	0.010729	0	11	49										C	132754904	G	C	132754904	4	2	6	1	0	0	0	0	0	1	0	0	3317	1294	45	1	544	1	CHCHD3	7	132754904	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5040174	132754904	26383759	328	1041										
PTN	5764	broad.mit.edu	37	chr7	136936106	136936106	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggctgtgttcaggtcacattCtccccaggcctggaactggt	12	12	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:136936106C>T	uc003vtq.2	-	4	685	c.322G>A	c.(322-324)GAA>AAA	p.E108K	PTN_uc010lmx.2_Missense_Mutation_p.E108K|PTN_uc003vtr.1_Missense_Mutation_p.E108K	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	108					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						AGGTCACATTCTCCCCAGGCC	0.507													0	0	0	0.01441	0	57	211										T	136936106	C	T	136936106	3	4	6	1	0	0	0	0	1	0	0	0	12768	922	32	1	192	1	PTN	7	136936106	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4181202	136936106	22202557	329	1042										
PAXIP1	22976	broad.mit.edu	37	chr7	154738261	154738261	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttctcggcataaatgaaggtCattttcacaggatattaaaa	7	6	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr7:154738261C>T	uc003wlp.2	-	19	3137	c.3094G>A	c.(3094-3096)GAC>AAC	p.D1032N	LOC100132707_uc011kvr.1_Intron|LOC100132707_uc003wlo.2_Intron|PAXIP1_uc003wlq.1_Missense_Mutation_p.D998N|PAXIP1_uc011kvs.1_Missense_Mutation_p.D996N	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	1032	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		AAATGAAGGTCATTTTCACAG	0.423													0	0	0	0.001168	0	6	40										T	154738261	C	T	154738261	3	4	6	1	0	0	0	0	1	0	0	0	11487	826	29	1	127	1	PAXIP1	7	154738261	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	17802155	154738261	4400402	330	1043										
RP1L1	94137	broad.mit.edu	37	chr8	10466192	10466192	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtcctcatgcccagagccttGacccccagtttctccccttt	6	18	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:10466192G>C	uc003wtc.2	-	4	5645	c.5416C>G	c.(5416-5418)CAA>GAA	p.Q1806E		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1806					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCAGAGCCTTGACCCCCAGTT	0.587													0	0	0	0.01441	0	80	308										C	10466192	G	C	10466192	3	2	6	1	0	0	0	0	1	0	0	0	13533	1299	45	1	1790	1	RP1L1	8	10466192	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		10466192	135897830	331	1044										
BIN3	55909	broad.mit.edu	37	chr8	22487503	22487503	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagggctcgatcacagtcttCtggatctggttcacctgtca	10	11	6	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:22487503C>T	uc003xcl.2	-	6	409	c.312G>A	c.(310-312)CAG>CAA	p.Q104Q	BIN3_uc003xck.2_Silent_p.Q56Q|BIN3_uc010ltw.2_Silent_p.Q50Q	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	104	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		TCACAGTCTTCTGGATCTGGT	0.537													0	0	0	0.000602	0	4	19										T	22487503	C	T	22487503	2	4	6	1	0	0	0	0	0	0	0	1	1434	912	32	1		1	BIN3	8	22487503	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	12021311	22487503	123876519	332	1045										
ZNF395	55893	broad.mit.edu	37	chr8	28206244	28206244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgcagcacagctcagtccaGaaagcgctggcaggccttct	11	14	2	1	rs12545851		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:28206244G>C	uc003xgq.2	-	10	1622	c.1534C>G	c.(1534-1536)CTG>GTG	p.L512V	ZNF395_uc003xgt.2_Missense_Mutation_p.L512V|ZNF395_uc003xgr.2_Missense_Mutation_p.L512V|ZNF395_uc003xgs.2_Missense_Mutation_p.L512V	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	512					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GCTCAGTCCAGAAAGCGCTGG	0.622													0	0	0	0.008871	0	14	60										C	28206244	G	C	28206244	3	2	6	1	0	0	0	0	1	0	0	0	17878	933	33	1	11	1	ZNF395	8	28206244	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5718741	28206244	118157778	333	1046										
EXTL3	2137	broad.mit.edu	37	chr8	28574875	28574875	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctctccaccttcgccctcatCattacccccggggaccctcg	6	21	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:28574875C>G	uc003xgz.1	+	3	1892	c.1299C>G	c.(1297-1299)ATC>ATG	p.I433M		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	433	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TCGCCCTCATCATTACCCCCG	0.622													0	0	0	0.010818	0	32	84										G	28574875	C	G	28574875	3	3	6	1	0	0	0	0	1	0	0	0	5327	816	29	1	1301	1	EXTL3	8	28574875	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	368631	28574875	117789147	334	1047										
IDO2	169355	broad.mit.edu	37	chr8	39806667	39806667	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcagtgacactttccatgcaGatacttcaaacaaaataatg	5	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:39806667G>C	uc010lwy.1	+	2	265	c.23_splice	c.e2-1	p.D8_splice	IDO2_uc003xno.1_Splice_Site	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1						tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2						TTTCCATGCAGATACTTCAAA	0.428													0	0	0	0.000602	0	4	16										C	39806667	G	C	39806667	5	2	6	1	0	0	0	0	0	0	1	0	7502	956	33	1	28	1	IDO2	8	39806667	Splice_Site	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11231792	39806667	106557355	335	1048										
CHRNB3	1142	broad.mit.edu	37	chr8	42585842	42585842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcctgacatagttctctttGaaaagtaagtatcacattgt	6	7	2	2	rs75170626		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:42585842G>A	uc003xpi.1	+	4	483	c.355G>A	c.(355-357)GAA>AAA	p.E119K		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	119	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AGTTCTCTTTGAAAAGTAAGT	0.284													0	0	0	0.003163	0	14	58										A	42585842	G	A	42585842	3	1	6	1	0	0	0	0	1	0	0	0	3392	1291	45	1	369	1	CHRNB3	8	42585842	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2779175	42585842	103778180	336	1049										
POTEA	340441	broad.mit.edu	37	chr8	43211963	43211963	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaagaacacttactagaactCaaaaatagccactatgagca	6	9	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:43211963C>G	uc003xpz.1	+	12	1465	c.1422C>G	c.(1420-1422)CTC>CTG	p.L474L	POTEA_uc003xqa.1_Silent_p.L428L	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	474	Potential.									ovary(1)	1						TACTAGAACTCAAAAATAGCC	0.353													0	0	0	0.013537	0	13	63										G	43211963	C	G	43211963	2	3	6	1	0	0	0	0	0	0	0	1	12261	813	29	1		1	POTEA	8	43211963	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	626121	43211963	103152059	337	1050										
KIAA0146	23514	broad.mit.edu	37	chr8	48641538	48641538	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctcccgggtggtcacatctCctgttctcaagaggcacctg							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:48641538C>T	uc003xqd.2	+	18	2488	c.2479C>T	c.(2479-2481)CCT>TCT	p.P827S	KIAA0146_uc011ldc.1_Missense_Mutation_p.P757S|KIAA0146_uc011ldd.1_Missense_Mutation_p.P767S|KIAA0146_uc003xqe.2_Missense_Mutation_p.P302S|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc010lxt.2_Intron|KIAA0146_uc011ldf.1_Missense_Mutation_p.P332S|KIAA0146_uc011ldg.1_Missense_Mutation_p.P317S|KIAA0146_uc003xqg.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	827											0		Lung NSC(58;0.175)				GGTCACATCTCCTGTTCTCAA	0.592													0	0	0	0.003954	0	24	91										T	48641538	C	T	48641538	3	4	6	1	0	0	0	0	1	0	0	0	8157	855	30	1	2549	1	KIAA0146	8	48641538	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5429575	48641538	97722484	338	1051	3	2								
KIAA0146	23514	broad.mit.edu	37	chr8	48641544	48641544	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggtggtcacatctcctgttCtcaagaggcacctgcaggtc							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:48641544C>T	uc003xqd.2	+	18	2494	c.2485C>T	c.(2485-2487)CTC>TTC	p.L829F	KIAA0146_uc011ldc.1_Missense_Mutation_p.L759F|KIAA0146_uc011ldd.1_Missense_Mutation_p.L769F|KIAA0146_uc003xqe.2_Missense_Mutation_p.L304F|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc010lxt.2_Intron|KIAA0146_uc011ldf.1_Missense_Mutation_p.L334F|KIAA0146_uc011ldg.1_Missense_Mutation_p.L319F|KIAA0146_uc003xqg.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	829											0		Lung NSC(58;0.175)				ATCTCCTGTTCTCAAGAGGCA	0.592													0	0	0	0.00333	0	24	90										T	48641544	C	T	48641544	3	4	6	1	0	0	0	0	1	0	0	0	8157	913	32	1	2555	1	KIAA0146	8	48641544	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6	48641544	97722478	339	1052	3	2								
ARFGEF1	10565	broad.mit.edu	37	chr8	68163633	68163633	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctttagctgtcttggccatCtgctccatttctaagttata	7	10	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:68163633C>G	uc003xxo.1	-	19	3141	c.2751G>C	c.(2749-2751)CAG>CAC	p.Q917H	ARFGEF1_uc003xxl.1_Missense_Mutation_p.Q371H	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	917					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCTTGGCCATCTGCTCCATTT	0.398													0	0	0	0.004482	0	7	50										G	68163633	C	G	68163633	3	3	6	1	0	0	0	0	1	0	0	0	852	912	32	1	2882	1	ARFGEF1	8	68163633	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	19522089	68163633	78200389	340	1053										
SLCO5A1	81796	broad.mit.edu	37	chr8	70650368	70650368	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcagttacaatggcactctCagctgtgtatgacaaactca	8	10	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:70650368C>G	uc003xyl.2	-	5	2037	c.1330G>C	c.(1330-1332)GAG>CAG	p.E444Q	SLCO5A1_uc010lzb.2_Intron|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.E444Q|SLCO5A1_uc010lzc.2_Intron	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	444	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ATGGCACTCTCAGCTGTGTAT	0.423													0	0	0	0.010729	0	11	82										G	70650368	C	G	70650368	3	3	6	1	0	0	0	0	1	0	0	0	14731	835	29	1	1240	1	SLCO5A1	8	70650368	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2486735	70650368	75713654	341	1054										
GDAP1	54332	broad.mit.edu	37	chr8	75262801	75262801	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taccattggacgcattcgttCagctctcaaaaggtacaaca	7	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:75262801C>T	uc003yah.2	+	1	184	c.105C>T	c.(103-105)TTC>TTT	p.F35F	GDAP1_uc011lfj.1_5'UTR|GDAP1_uc003yai.2_Intron	NM_018972	NP_061845	Q8TB36	GDAP1_HUMAN	ganglioside-induced differentiation-associated	35	GST N-terminal.					cytoplasm					0	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			CGCATTCGTTCAGCTCTCAAA	0.627													0	0	0	0.006122	0	14	58										T	75262801	C	T	75262801	2	4	6	1	0	0	0	0	0	0	0	1	6307	825	29	1		1	GDAP1	8	75262801	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4612433	75262801	71101221	342	1055										
KIAA1429	25962	broad.mit.edu	37	chr8	95541352	95541352	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcatcttcctcttcctcctCaggaatactgtctactgttc	4	14	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:95541352C>T	uc003ygo.1	-	7	839	c.826G>A	c.(826-828)GAG>AAG	p.E276K	KIAA1429_uc003ygp.2_Missense_Mutation_p.E276K|KIAA1429_uc010maz.1_5'Flank	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	276	Glu-rich.				mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			tcttcctcctcAGGAATACTG	0.194													0	0	0	0.008291	0	11	21										T	95541352	C	T	95541352	3	4	6	1	0	0	0	0	1	0	0	0	8231	835	29	1	4738	1	KIAA1429	8	95541352	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	20278551	95541352	50822670	343	1056										
KCNS2	3788	broad.mit.edu	37	chr8	99440459	99440459	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcccctacgtgctgcatttCtatcacaccggcaagcttca	6	15	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:99440459C>T	uc003yin.2	+	2	602	c.252C>T	c.(250-252)TTC>TTT	p.F84F		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	84	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TGCTGCATTTCTATCACACCG	0.557													0	0	0	0.013726	0	34	138										T	99440459	C	T	99440459	2	4	6	1	0	0	0	0	0	0	0	1	8089	912	32	1		1	KCNS2	8	99440459	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3899107	99440459	46923563	344	1057										
KCNS2	3788	broad.mit.edu	37	chr8	99440510	99440510	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagctatgtgtcttctccttCagccaggagatcgagtactg	11	10	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:99440510C>A	uc003yin.2	+	2	653	c.303C>A	c.(301-303)TTC>TTA	p.F101L		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	101	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TCTTCTCCTTCAGCCAGGAGA	0.537													1	0	1.62957e-23	0.00874	1.69344e-23	38	122										A	99440510	C	A	99440510	3	1	6	1	0	0	0	0	1	0	0	0	8089	825	29	3	305	3	KCNS2	8	99440510	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	51	99440510	46923512	345	1058										
RIMS2	9699	broad.mit.edu	37	chr8	104987673	104987673	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttcaccatcagggtctcctCatcgagtagatgttatagga	10	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:104987673C>G	uc003yls.2	+	14	2441	c.2200C>G	c.(2200-2202)CAT>GAT	p.H734D	RIMS2_uc003ylp.2_Missense_Mutation_p.H956D|RIMS2_uc003ylw.2_Missense_Mutation_p.H748D|RIMS2_uc003ylq.2_Missense_Mutation_p.H748D|RIMS2_uc003ylr.2_Missense_Mutation_p.H795D|RIMS2_uc003ylt.2_Missense_Mutation_p.H341D	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1018					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGGGTCTCCTCATCGAGTAGA	0.413										HNSCC(12;0.0054)			0	0	0	0.004007	0	14	64										G	104987673	C	G	104987673	3	3	6	1	0	0	0	0	1	0	0	0	13368	826	29	1	3054	1	RIMS2	8	104987673	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5547163	104987673	41376349	346	1059										
UTP23	84294	broad.mit.edu	37	chr8	117782565	117782565	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaatgtctgctttccatggTtgaagagggaaatcctcatc	10	8	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:117782565T>C	uc003yoc.2	+	2	424	c.323T>C	c.(322-324)GTT>GCT	p.V108A		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	108					rRNA processing	nucleolus					0						CTTTCCATGGTTGAAGAGGGA	0.373													0	0	0	0.007291	0	26	154										C	117782565	T	C	117782565	3	2	6	1	0	0	0	0	1	0	0	0	17097	1725	60	5	329	5	UTP23	8	117782565	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	12794892	117782565	28581457	347	1060										
FER1L6	654463	broad.mit.edu	37	chr8	125052230	125052230	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccaaagtcacgttcctttctCactgccagacaacaaaggta	6	13	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:125052230C>T	uc003yqw.2	+	20	2778	c.2572C>T	c.(2572-2574)CAC>TAC	p.H858Y	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	858	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTTCCTTTCTCACTGCCAGAC	0.522													0	0	0	0.004656	0	24	127										T	125052230	C	T	125052230	3	4	6	1	0	0	0	0	1	0	0	0	5815	826	29	1	2646	1	FER1L6	8	125052230	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7269665	125052230	21311792	348	1061										
FAM83H	286077	broad.mit.edu	37	chr8	144808291	144808291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagcagccgatcgcgctcctCcgcgctggctggcagcgtgc	14	17	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr8:144808291C>T	uc003yzk.2	-	5	3409	c.3340G>A	c.(3340-3342)GAG>AAG	p.E1114K	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	1114					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCGCGCTCCTCCGCGCTGGCT	0.652													0	0	0	0.001168	0	3	14										T	144808291	C	T	144808291	3	4	6	1	0	0	0	0	1	0	0	0	5640	864	30	1	203	1	FAM83H	8	144808291	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	19756061	144808291	1555731	349	1062										
BNC2	54796	broad.mit.edu	37	chr9	16435866	16435866	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agtggggtctgtaaattcttCcttcaccttgatgacgtcct	9	10	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:16435866C>A	uc003zml.2	-	6	2466	c.2326G>T	c.(2326-2328)GAA>TAA	p.E776*	BNC2_uc011lmw.1_Nonsense_Mutation_p.E681*|BNC2_uc003zmm.2_Nonsense_Mutation_p.E734*|BNC2_uc003zmq.1_Nonsense_Mutation_p.E790*|BNC2_uc003zmr.1_Nonsense_Mutation_p.E813*|BNC2_uc003zmp.1_Nonsense_Mutation_p.E804*|BNC2_uc010mij.1_Nonsense_Mutation_p.E698*|BNC2_uc011lmv.1_Nonsense_Mutation_p.E602*|BNC2_uc003zmo.1_Nonsense_Mutation_p.E698*|BNC2_uc003zmj.2_Nonsense_Mutation_p.E541*|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Nonsense_Mutation_p.E541*|BNC2_uc003zmn.1_Nonsense_Mutation_p.E541*	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	776					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GTAAATTCTTCCTTCACCTTG	0.498													1	0	3.62473e-10	0.012319	3.71685e-10	22	57										A	16435866	C	A	16435866	4	1	6	1	0	0	0	0	0	1	0	0	1475	864	30	3	981	3	BNC2	9	16435866	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		16435866	124777565	350	1063										
TPM2	7169	broad.mit.edu	37	chr9	35689748	35689748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttgtcggcttcggcctgctCggcgcggtcgatggcgttct	15	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:35689748C>T	uc003zxq.2	-	1	306	c.67G>A	c.(67-69)GAG>AAG	p.E23K	TPM2_uc003zxr.2_Missense_Mutation_p.E23K|TPM2_uc003zxs.2_Missense_Mutation_p.E23K|TPM2_uc010mkz.2_Missense_Mutation_p.E23K|TPM2_uc011lpa.1_Missense_Mutation_p.E23K	NM_213674	NP_998839	P07951	TPM2_HUMAN	tropomyosin 2 (beta) isoform 2	23	By similarity.				muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			ovary(1)	1	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCGGCCTGCTCGGCGCGGTCG	0.677													0	0	0	0.01441	0	55	193										T	35689748	C	T	35689748	3	4	6	1	0	0	0	0	1	0	0	0	16403	893	31	1	990	1	TPM2	9	35689748	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	19253882	35689748	105523683	351	1064										
CREB3	10488	broad.mit.edu	37	chr9	35736618	35736618	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gacctcttctcagagcctctCtgccgaggtcccatcctccc	7	19	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:35736618C>G	uc003zxv.2	+	9	1464	c.1011C>G	c.(1009-1011)CTC>CTG	p.L337L	CREB3_uc010mla.2_Silent_p.L256L	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	361	Lumenal (Potential).|Pro-rich.				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		CAGAGCCTCTCTGCCGAGGTC	0.587											OREG0019176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	54	267										G	35736618	C	G	35736618	2	3	6	1	0	0	0	0	0	0	0	1	3855	900	32	1		1	CREB3	9	35736618	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	46870	35736618	105476813	352	1065										
AGTPBP1	23287	broad.mit.edu	37	chr9	88190360	88190360	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acaaaattttgctcccatctCttccagttctcgggtaccaa	5	13	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:88190360C>T	uc011ltd.1	-	24	3406	c.3373G>A	c.(3373-3375)GAG>AAG	p.E1125K	AGTPBP1_uc004aod.3_Missense_Mutation_p.E751K|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.E1085K|AGTPBP1_uc011lte.1_Missense_Mutation_p.E1137K	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1125					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GCTCCCATCTCTTCCAGTTCT	0.363													0	0	0	0.013726	0	30	84										T	88190360	C	T	88190360	3	4	6	1	0	0	0	0	1	0	0	0	400	922	32	1	315	1	AGTPBP1	9	88190360	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	52453742	88190360	53023071	353	1066										
PTPDC1	138639	broad.mit.edu	37	chr9	96847533	96847533	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctttccttatatgttctagGaaatttagaacgtccaacac	5	10	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:96847533G>C	uc004auf.1	+	3	423	c.83G>C	c.(82-84)GGA>GCA	p.G28A	PTPDC1_uc004aug.1_Missense_Mutation_p.G28A|PTPDC1_uc004auh.1_Missense_Mutation_p.R80T|PTPDC1_uc010mrj.1_Missense_Mutation_p.G82A|PTPDC1_uc010mri.1_Missense_Mutation_p.R80T	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	28							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						TATGTTCTAGGAAATTTAGAA	0.408													0	0	0	0.006122	0	16	64										C	96847533	G	C	96847533	3	2	6	1	0	0	0	0	1	0	0	0	12773	1188	41	1	331	1	PTPDC1	9	96847533	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8657173	96847533	44365898	354	1067										
PTCH1	5727	broad.mit.edu	37	chr9	98232132	98232132	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatatccagtctcctgtcctCgcgtcgatataaatccatgc	6	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:98232132C>G	uc004avk.3	-	13	1998	c.1810G>C	c.(1810-1812)GAG>CAG	p.E604Q	PTCH1_uc010mro.2_Missense_Mutation_p.E453Q|PTCH1_uc010mrp.2_Missense_Mutation_p.E453Q|PTCH1_uc010mrq.2_Missense_Mutation_p.E453Q|PTCH1_uc004avl.3_Missense_Mutation_p.E453Q|PTCH1_uc010mrr.2_Missense_Mutation_p.E538Q|PTCH1_uc004avm.3_Missense_Mutation_p.E603Q|PTCH1_uc010mrs.1_Missense_Mutation_p.E272Q	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	604	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTCCTGTCCTCGCGTCGATAT	0.438									Basal_Cell_Nevus_syndrome				0	0	0	0.011902	0	46	158										G	98232132	C	G	98232132	3	3	6	1	0	0	0	0	1	0	0	0	12730	893	31	1	2577	1	PTCH1	9	98232132	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1384599	98232132	42981299	355	1068										
C9orf102	375748	broad.mit.edu	37	chr9	98691087	98691087	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acaaaatcagaggaaagactCaagattgtaaaagagttcaa	8	5	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:98691087C>G	uc004avt.3	+	11	2113	c.1725C>G	c.(1723-1725)CTC>CTG	p.L575L	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Silent_p.L277L|C9orf102_uc010mry.1_Silent_p.L277L|C9orf102_uc010mrz.2_Silent_p.L386L|C9orf102_uc004avu.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	575	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				AGGAAAGACTCAAGATTGTAA	0.368													0	0	0	0.014323	0	22	102										G	98691087	C	G	98691087	2	3	6	1	0	0	0	0	0	0	0	1	2445	813	29	1		1	C9orf102	9	98691087	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	458955	98691087	42522344	356	1069										
COL15A1	1306	broad.mit.edu	37	chr9	101825366	101825366	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcctccaccaaaccctatttCaagtgccaattatgagaagc	6	13	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:101825366C>G	uc004azb.1	+	39	3832	c.3626C>G	c.(3625-3627)TCA>TGA	p.S1209*		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	1209	Nonhelical region 10 (NC10).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				AACCCTATTTCAAGTGCCAAT	0.269													0	0	0	0.008871	0	15	53										G	101825366	C	G	101825366	4	3	6	1	0	0	0	0	0	1	0	0	3672	838	29	1	3780	1	COL15A1	9	101825366	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3134279	101825366	39388065	357	1070										
ZNF462	58499	broad.mit.edu	37	chr9	109687655	109687655	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctcgttgaaacttggggctCacaaacagtgtcacacgggt	12	10	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:109687655C>T	uc004bcz.2	+	3	1751	c.1462C>T	c.(1462-1464)CAC>TAC	p.H488Y	ZNF462_uc010mto.2_Missense_Mutation_p.H336Y|ZNF462_uc004bda.2_Missense_Mutation_p.H336Y	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	488	C2H2-type 5.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ACTTGGGGCTCACAAACAGTG	0.448													0	0	0	0.008871	0	19	76										T	109687655	C	T	109687655	3	4	6	1	0	0	0	0	1	0	0	0	17923	826	29	1	1468	1	ZNF462	9	109687655	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7862289	109687655	31525776	358	1071										
CTNNAL1	8727	broad.mit.edu	37	chr9	111741738	111741738	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttggactgaaaataaagattCtcccgaagagcttcaatatt	7	7	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:111741738C>T	uc004bdo.1	-	7	966	c.924G>A	c.(922-924)GAG>GAA	p.E308E	CTNNAL1_uc010mts.1_Silent_p.E44E|CTNNAL1_uc010mtt.1_Silent_p.E308E|CTNNAL1_uc004bdp.1_Silent_p.E308E	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	308					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		AATAAAGATTCTCCCGAAGAG	0.418													0	0	0	0.004482	0	9	30										T	111741738	C	T	111741738	2	4	6	1	0	0	0	0	0	0	0	1	4015	912	32	1		1	CTNNAL1	9	111741738	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2054083	111741738	29471693	359	1072										
SVEP1	79987	broad.mit.edu	37	chr9	113231341	113231341	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atccggcagctttcacaggtGaaatgttccagattataata	8	8	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:113231341G>C	uc010mtz.2	-	17	3376	c.3039C>G	c.(3037-3039)TTC>TTG	p.F1013L	SVEP1_uc010mua.1_Missense_Mutation_p.F1013L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1013					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TTTCACAGGTGAAATGTTCCA	0.438													0	0	0	0.006122	0	17	79										C	113231341	G	C	113231341	3	2	6	1	0	0	0	0	1	0	0	0	15417	1281	45	1	7804	1	SVEP1	9	113231341	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1489603	113231341	27982090	360	1073										
SVEP1	79987	broad.mit.edu	37	chr9	113312147	113312147	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accttcatgcaatgcccggcGagctaaagcctcaaattctt	7	13	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:113312147G>A	uc010mtz.2	-	2	1106	c.769C>T	c.(769-771)CGC>TGC	p.R257C	SVEP1_uc010mua.1_Missense_Mutation_p.R257C|SVEP1_uc004beu.2_Missense_Mutation_p.R257C|SVEP1_uc004bev.2_5'UTR	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	257	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AATGCCCGGCGAGCTAAAGCC	0.478													0	0	0	0.001168	0	6	21										A	113312147	G	A	113312147	3	1	6	1	0	0	0	0	1	0	0	0	15417	1058	37	1	10134	1	SVEP1	9	113312147	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	80806	113312147	27901284	361	1074										
BSPRY	54836	broad.mit.edu	37	chr9	116131969	116131969	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcagatgatcgaaagaccctGaccttcagcaccaagaagtc	8	12	2	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:116131969G>A	uc004bhg.3	+	6	804	c.756G>A	c.(754-756)CTG>CTA	p.L252L	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	252	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						GAAAGACCCTGACCTTCAGCA	0.567													0	0	0	0.009535	0	30	93										A	116131969	G	A	116131969	2	1	6	1	0	0	0	0	0	0	0	1	1532	1277	45	1		1	BSPRY	9	116131969	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2819822	116131969	25081462	362	1075										
SCAI	286205	broad.mit.edu	37	chr9	127764247	127764247	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcattcctttattgtaccttCactatcagaacgacctgtgg	7	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:127764247C>T	uc004bpe.2	-	12	1222	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K	SCAI_uc004bpd.2_Missense_Mutation_p.E404K|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	381					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						ATTGTACCTTCACTATCAGAA	0.473													0	0	0	0.01441	0	46	158										T	127764247	C	T	127764247	3	4	6	1	0	0	0	0	1	0	0	0	13869	835	29	1	707	1	SCAI	9	127764247	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	11632278	127764247	13449184	363	1076										
GAPVD1	26130	broad.mit.edu	37	chr9	128111713	128111713	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacatgattctccccgtgacGaagcactgcagaacatctcg	8	14	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:128111713G>A	uc010mwx.2	+	21	3594	c.3268G>A	c.(3268-3270)GAA>AAA	p.E1090K	GAPVD1_uc004bpp.2_Missense_Mutation_p.E1099K|GAPVD1_uc004bpq.2_Missense_Mutation_p.E1072K|GAPVD1_uc004bpr.2_Missense_Mutation_p.E1051K|GAPVD1_uc004bps.2_Missense_Mutation_p.E1045K|GAPVD1_uc004bpt.2_Missense_Mutation_p.E105K	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1090					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TCCCCGTGACGAAGCACTGCA	0.478													0	0	0	0.005524	0	38	118										A	128111713	G	A	128111713	3	1	6	1	0	0	0	0	1	0	0	0	6239	1059	37	1	3369	1	GAPVD1	9	128111713	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	347466	128111713	13101718	364	1077										
ST6GALNAC6	30815	broad.mit.edu	37	chr9	130652994	130652994	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agacggcatatgcttccatgTtggggaacaccaggcccgct	12	12	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:130652994T>C	uc004bso.1	-	5	745	c.626A>G	c.(625-627)AAC>AGC	p.N209S	ST6GALNAC6_uc004bsn.1_Missense_Mutation_p.N175S|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Missense_Mutation_p.N209S|ST6GALNAC6_uc004bsq.1_Missense_Mutation_p.N175S|ST6GALNAC6_uc004bsr.2_Missense_Mutation_p.N175S|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	209	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0						TGCTTCCATGTTGGGGAACAC	0.642													0	0	0	0.007413	0	15	76										C	130652994	T	C	130652994	3	2	6	1	0	0	0	0	1	0	0	0	15227	1725	60	5	387	5	ST6GALNAC6	9	130652994	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	2541281	130652994	10560437	365	1078										
NAIF1	203245	broad.mit.edu	37	chr9	130829327	130829327	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccagctcctccacgatgatCtccacctcccgctctgagaa	6	18	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:130829327C>T	uc004bta.2	-	1	273	c.54G>A	c.(52-54)GAG>GAA	p.E18E	NAIF1_uc004bsz.2_RNA|SLC25A25_uc004btb.2_5'Flank	NM_197956	NP_931045	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	18	Required for nuclear localization and apoptosis-inducing activity.				apoptosis|induction of apoptosis	nucleus					0						CCACGATGATCTCCACCTCCC	0.577													0	0	0	0.01441	0	68	240										T	130829327	C	T	130829327	2	4	6	1	0	0	0	0	0	0	0	1	10146	912	32	1		1	NAIF1	9	130829327	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	176333	130829327	10384104	366	1079										
LCN2	3934	broad.mit.edu	37	chr9	130914288	130914288	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctcaaaacagggagtacttCaagatcaccctctacggtgg	9	11	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:130914288C>G	uc004bto.1	+	4	532	c.459C>G	c.(457-459)TTC>TTG	p.F153L	LCN2_uc011map.1_Missense_Mutation_p.F153L	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	153					apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						GGGAGTACTTCAAGATCACCC	0.547													0	0	0	0.006999	0	36	155										G	130914288	C	G	130914288	3	3	6	1	0	0	0	0	1	0	0	0	8684	825	29	1	473	1	LCN2	9	130914288	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	84961	130914288	10299143	367	1080										
SPTAN1	6709	broad.mit.edu	37	chr9	131395126	131395126	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caagaatacatggctttcatGatcagccgcgaaactgagaa	9	9	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:131395126G>A	uc004bvl.3	+	55	7298	c.7185G>A	c.(7183-7185)ATG>ATA	p.M2395I	SPTAN1_uc004bvm.3_Missense_Mutation_p.M2400I|SPTAN1_uc004bvn.3_Missense_Mutation_p.M2375I|SPTAN1_uc004bvo.3_Missense_Mutation_p.M162I|SPTAN1_uc004bvp.3_Missense_Mutation_p.M138I	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2395	EF-hand 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGGCTTTCATGATCAGCCGCG	0.602													0	0	0	0.003271	0	32	178										A	131395126	G	A	131395126	3	1	6	1	0	0	0	0	1	0	0	0	15116	1290	45	1	7418	1	SPTAN1	9	131395126	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	480838	131395126	9818305	368	1081										
ZER1	10444	broad.mit.edu	37	chr9	131517773	131517773	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgtccagcaggtagcccagGgtgccatccaggttgcgcaa	13	12	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:131517773G>A	uc004bwa.1	-	2	505	c.72C>T	c.(70-72)ACC>ACT	p.T24T		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	24					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						GGTAGCCCAGGGTGCCATCCA	0.622													0	0	0	0.00632	0	28	105										A	131517773	G	A	131517773	2	1	6	1	0	0	0	0	0	0	0	1	17622	1219	43	2		2	ZER1	9	131517773	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	122647	131517773	9695658	369	1082										
DOLK	22845	broad.mit.edu	37	chr9	131709436	131709436	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acgtagaaggcctgcactgcGagggccacggcgcaccacga	14	14	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:131709436G>C	uc004bwr.2	-	1	577	c.147C>G	c.(145-147)CTC>CTG	p.L49L	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	49	Cytoplasmic (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						CCTGCACTGCGAGGGCCACGG	0.602													0	0	0	0.010504	0	19	68										C	131709436	G	C	131709436	2	2	6	1	0	0	0	0	0	0	0	1	4703	1045	37	1		1	DOLK	9	131709436	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	191663	131709436	9503995	370	1083										
NUP188	23511	broad.mit.edu	37	chr9	131745618	131745618	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggatgtcattgcttcttgtGtcaactgcttaactgttttg	9	7	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:131745618G>A	uc004bws.1	+	18	1865	c.1843G>A	c.(1843-1845)GTC>ATC	p.V615I	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	615					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TGCTTCTTGTGTCAACTGCTT	0.433													0	0	0	0.007291	0	26	129										A	131745618	G	A	131745618	3	1	6	1	0	0	0	0	1	0	0	0	10758	1377	48	2	1913	2	NUP188	9	131745618	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	36182	131745618	9467813	371	1084										
ASS1	445	broad.mit.edu	37	chr9	133327632	133327632	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgctatgtccagcaaaggctCcgtggttctggcctacagtg	12	12	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:133327632C>T	uc004bzm.2	+	3	373	c.17C>T	c.(16-18)TCC>TTC	p.S6F	ASS1_uc004bzn.2_Missense_Mutation_p.S6F|ASS1_uc010mza.2_Missense_Mutation_p.S82F|ASS1_uc004bzo.2_Missense_Mutation_p.S6F|ASS1_uc010mzb.2_Missense_Mutation_p.S44F|ASS1_uc004bzp.2_Missense_Mutation_p.S6F|ASS1_uc010mzc.2_Missense_Mutation_p.S6F	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	6					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	AGCAAAGGCTCCGTGGTTCTG	0.627													0	0	0	0.001855	0	5	23										T	133327632	C	T	133327632	3	4	6	1	0	0	0	0	1	0	0	0	1061	855	30	1	19	1	ASS1	9	133327632	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1582014	133327632	7885799	372	1085										
LAMC3	10319	broad.mit.edu	37	chr9	133907468	133907468	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgaactcctcatctctctaGaccggctcaacacgtttggg	8	15	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:133907468G>A	uc004caa.1	+	3	813	c.715G>A	c.(715-717)GAC>AAC	p.D239N		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	239	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CATCTCTCTAGACCGGCTCAA	0.567													0	0	0	0.004878	0	36	207										A	133907468	G	A	133907468	3	1	6	1	0	0	0	0	1	0	0	0	8616	942	33	1	725	1	LAMC3	9	133907468	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	579836	133907468	7305963	373	1086										
C9orf96	169436	broad.mit.edu	37	chr9	136266896	136266896	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accacccggaagccaaggctCcctgcaaccaagccatcacc	7	19	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:136266896C>T	uc004cdk.2	+	13	1289	c.1228C>T	c.(1228-1230)CCC>TCC	p.P410S	C9orf96_uc004cdl.2_Intron	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	410							ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		AGCCAAGGCTCCCTGCAACCA	0.622													0	0	0	0.001855	0	14	37										T	136266896	C	T	136266896	3	4	6	1	0	0	0	0	1	0	0	0	2508	855	30	1	1278	1	C9orf96	9	136266896	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2359428	136266896	4946535	374	1087										
MRPS2	51116	broad.mit.edu	37	chr9	138395832	138395832	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctccgctggctgtgcacctCtactgcaggctcttccagac	9	16	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:138395832C>G	uc004cfv.3	+	4	818	c.744C>G	c.(742-744)CTC>CTG	p.L248L	MRPS2_uc004cfw.3_Silent_p.L158L|MRPS2_uc004cfx.3_Silent_p.L163L|MRPS2_uc010nat.2_Silent_p.L229L|uc004cfy.2_Intron	NM_016034	NP_057118	Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	248					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		CTGTGCACCTCTACTGCAGGC	0.632													0	0	0	0.012213	0	30	113										G	138395832	C	G	138395832	2	3	6	1	0	0	0	0	0	0	0	1	9831	900	32	1		1	MRPS2	9	138395832	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2128936	138395832	2817599	375	1088										
KCNT1	57582	broad.mit.edu	37	chr9	138669288	138669288	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatgggctgtacaacttcatCgtgccactgcgggcctacta	10	12	1	0	rs149452823		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:138669288C>T	uc011mdq.1	+	21	2528	c.2454C>T	c.(2452-2454)ATC>ATT	p.I818I	KCNT1_uc011mdr.1_Silent_p.I645I|KCNT1_uc010nbf.2_Silent_p.I773I|KCNT1_uc004cgo.1_Silent_p.I567I	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	818						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		ACAACTTCATCGTGCCACTGC	0.602													0	0	0	0.007413	0	17	87										T	138669288	C	T	138669288	2	4	6	1	0	0	0	0	0	0	0	1	8091	874	31	1		1	KCNT1	9	138669288	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	273456	138669288	2544143	376	1089										
TRAF2	7186	broad.mit.edu	37	chr9	139802612	139802612	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgaaaaggagcgccacctgGagcacgagtgcccggagaga	16	10	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:139802612G>C	uc010nbu.2	+	6	630	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	TRAF2_uc010nbv.1_Missense_Mutation_p.E205Q|TRAF2_uc004cjv.2_Missense_Mutation_p.E153Q|TRAF2_uc011mek.1_Missense_Mutation_p.E142Q|TRAF2_uc010nbw.2_Missense_Mutation_p.E153Q	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	153	TRAF-type 1.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		GCGCCACCTGGAGCACGAGTG	0.662													0	0	0	0.013537	0	13	35										C	139802612	G	C	139802612	3	2	6	1	0	0	0	0	1	0	0	0	16435	1175	41	1	471	1	TRAF2	9	139802612	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1133324	139802612	1410819	377	1090										
NPDC1	56654	broad.mit.edu	37	chr9	139937474	139937474	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	catgtgcaccaggaggacacCttgcccgcctcttcagggca	11	15	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr9:139937474C>G	uc004ckt.2	-	2	399	c.164G>C	c.(163-165)AGG>ACG	p.R55T	NPDC1_uc004ckr.2_Missense_Mutation_p.R55T|NPDC1_uc004cks.2_Missense_Mutation_p.R133T|NPDC1_uc004cku.2_Missense_Mutation_p.R55T	NM_015392	NP_056207	Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and	55						integral to membrane					0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		AGGAGGACACCTTGCCCGCCT	0.687													0	0	0	0.00245	0	14	30										G	139937474	C	G	139937474	3	3	6	1	0	0	0	0	1	0	0	0	10573	681	24	4	845	4	NPDC1	9	139937474	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	134862	139937474	1275957	378	1091										
DIP2C	22982	broad.mit.edu	37	chr10	395346	395346	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagcatcacggcgatcttctCagctctcttgtgcagctgca	9	14	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:395346C>G	uc001ifp.2	-	25	3124	c.3034G>C	c.(3034-3036)GAG>CAG	p.E1012Q	DIP2C_uc009xhi.1_Missense_Mutation_p.E398Q	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1012						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GCGATCTTCTCAGCTCTCTTG	0.622													0	0	0	0.012319	0	22	83										G	395346	C	G	395346	3	3	6	1	0	0	0	0	1	0	0	0	4529	835	29	1	1688	1	DIP2C	10	395346	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		395346	135139401	379	1092										
RBM17	84991	broad.mit.edu	37	chr10	6143281	6143281	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcgccccagtcattgacctGaagcgaggtggctcctcaga	11	14	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:6143281G>A	uc001ijb.2	+	3	397	c.171G>A	c.(169-171)CTG>CTA	p.L57L	RBM17_uc010qav.1_Silent_p.L57L	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	57					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						TCATTGACCTGAAGCGAGGTG	0.483													0	0	0	0.004482	0	9	49										A	6143281	G	A	6143281	2	1	6	1	0	0	0	0	0	0	0	1	13119	1277	45	1		1	RBM17	10	6143281	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5747935	6143281	129391466	380	1093										
UPF2	26019	broad.mit.edu	37	chr10	11994206	11994206	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcaataggaaatggatggtCttttgtccaaacctccaaac	7	9	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:11994206C>G	uc001ila.2	-	14	3367	c.2893G>C	c.(2893-2895)GAC>CAC	p.D965H	UPF2_uc001ilb.2_Missense_Mutation_p.D965H|UPF2_uc001ilc.2_Missense_Mutation_p.D965H|UPF2_uc009xiz.1_Missense_Mutation_p.D965H	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	965	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				AATGGATGGTCTTTTGTCCAA	0.308													0	0	0	0.012319	0	23	80										G	11994206	C	G	11994206	3	3	6	1	0	0	0	0	1	0	0	0	17001	913	32	1	957	1	UPF2	10	11994206	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5850925	11994206	123540541	381	1094										
MSRB2	22921	broad.mit.edu	37	chr10	23408326	23408326	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaagccacacagggatcctGagacgtctggatacctcgtt	11	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:23408326G>A	uc001iro.2	+	4	501	c.390G>A	c.(388-390)CTG>CTA	p.L130L		NM_012228	NP_036360	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2 precursor	130					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0					L-Methionine(DB00134)	CAGGGATCCTGAGACGTCTGG	0.512													0	0	0	0.00278	0	25	94										A	23408326	G	A	23408326	2	1	6	1	0	0	0	0	0	0	0	1	9888	1277	45	1		1	MSRB2	10	23408326	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11414120	23408326	112126421	382	1095										
ANKRD26	22852	broad.mit.edu	37	chr10	27323766	27323766	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcatattgatactgtctttCttttaagtgattacattcac	4	7	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:27323766C>G	uc001ith.2	-	24	3782	c.3610G>C	c.(3610-3612)GAA>CAA	p.E1204Q	ANKRD26_uc001itg.2_Missense_Mutation_p.E891Q|ANKRD26_uc009xku.1_Missense_Mutation_p.E1205Q	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1204	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TACTGTCTTTCTTTTAAGTGA	0.289													0	0	0	0.003954	0	27	67										G	27323766	C	G	27323766	3	3	6	1	0	0	0	0	1	0	0	0	654	922	32	1	1563	1	ANKRD26	10	27323766	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3915440	27323766	108210981	383	1096										
ANKRD26	22852	broad.mit.edu	37	chr10	27323874	27323874	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacaatagcatgaaactggtCttggatattaatcactgtct	7	8	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:27323874C>T	uc001ith.2	-	24	3674	c.3502G>A	c.(3502-3504)GAC>AAC	p.D1168N	ANKRD26_uc001itg.2_Missense_Mutation_p.D855N|ANKRD26_uc009xku.1_Missense_Mutation_p.D1169N	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1168	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGAAACTGGTCTTGGATATTA	0.368													0	0	0	0.01441	0	59	203										T	27323874	C	T	27323874	3	4	6	1	0	0	0	0	1	0	0	0	654	913	32	1	1671	1	ANKRD26	10	27323874	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	108	27323874	108210873	384	1097										
ARMC4	55130	broad.mit.edu	37	chr10	28151455	28151455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgctatgttggtaatggcagCacatacacttgccagaactt	9	9	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:28151455C>T	uc009xky.2	-	18	2805	c.2707G>A	c.(2707-2709)GCT>ACT	p.A903T	ARMC4_uc010qds.1_Missense_Mutation_p.A428T|ARMC4_uc010qdt.1_Missense_Mutation_p.A595T|ARMC4_uc001itz.2_Missense_Mutation_p.A903T	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	903	ARM 7.						binding			ovary(4)|skin(2)	6						GTAATGGCAGCACATACACTT	0.373													0	0	0	0.005443	0	29	96										T	28151455	C	T	28151455	3	4	6	1	0	0	0	0	1	0	0	0	953	710	25	2	439	2	ARMC4	10	28151455	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	827581	28151455	107383292	385	1098										
ITGB1	3688	broad.mit.edu	37	chr10	33200926	33200926	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctacaaacacactgtccgcaGacgcactctccattgttact	5	15	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:33200926G>A	uc001iws.3	-	12	1732	c.1596C>T	c.(1594-1596)GTC>GTT	p.V532V	ITGB1_uc001iwp.3_Silent_p.V532V|ITGB1_uc001iwq.3_Silent_p.V532V|ITGB1_uc001iwr.3_Silent_p.V532V|ITGB1_uc001iwt.3_Silent_p.V532V|ITGB1_uc001iwu.1_Silent_p.V532V	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	532	Extracellular (Potential).|Cysteine-rich tandem repeats.|II.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				ACTGTCCGCAGACGCACTCTC	0.398													0	0	0	0.01441	0	48	129										A	33200926	G	A	33200926	2	1	6	1	0	0	0	0	0	0	0	1	7890	929	33	1		1	ITGB1	10	33200926	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5049471	33200926	102333821	386	1099										
ITGB1	3688	broad.mit.edu	37	chr10	33224454	33224454	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acacagcaaactgaactgatCagtccaatccagaaaattgg	7	10	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:33224454C>T	uc001iws.3	-	2	169	c.33G>A	c.(31-33)CTG>CTA	p.L11L	ITGB1_uc001iwp.3_Silent_p.L11L|ITGB1_uc001iwq.3_Silent_p.L11L|ITGB1_uc001iwr.3_Silent_p.L11L|ITGB1_uc001iwt.3_Silent_p.L11L|ITGB1_uc001iwu.1_Silent_p.L11L	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	11					axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CTGAACTGATCAGTCCAATCC	0.294													0	0	0	0.013537	0	10	60										T	33224454	C	T	33224454	2	4	6	1	0	0	0	0	0	0	0	1	7890	813	29	1		1	ITGB1	10	33224454	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	23528	33224454	102310293	387	1100										
PHYHIPL	84457	broad.mit.edu	37	chr10	61005268	61005268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcaccgtggcagaaatcactGgtcatcagctcatgagtttg	11	10	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:61005268G>A	uc001jkk.3	+	5	1314	c.1048G>A	c.(1048-1050)GGT>AGT	p.G350S	PHYHIPL_uc001jkl.3_Missense_Mutation_p.G304S|PHYHIPL_uc001jkm.3_Missense_Mutation_p.G324S	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	350											0						AGAAATCACTGGTCATCAGCT	0.448													0	0	0	0.007835	0	41	96										A	61005268	G	A	61005268	3	1	6	1	0	0	0	0	1	0	0	0	11867	1348	47	2	1098	2	PHYHIPL	10	61005268	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	27780814	61005268	74529479	388	1101										
RTKN2	219790	broad.mit.edu	37	chr10	63977986	63977986	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaatcctgcaaatgcatcctCagccatacaagctggctggg	9	12	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:63977986C>T	uc001jlw.2	-	8	953	c.856G>A	c.(856-858)GAG>AAG	p.E286K	RTKN2_uc009xpf.1_Missense_Mutation_p.E67K	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	286	PH.				signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					AATGCATCCTCAGCCATACAA	0.393													0	0	0	0.013537	0	13	78										T	63977986	C	T	63977986	3	4	6	1	0	0	0	0	1	0	0	0	13723	835	29	1	993	1	RTKN2	10	63977986	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2972718	63977986	71556761	389	1102										
ZNF365	22891	broad.mit.edu	37	chr10	64415153	64415153	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	catctaaagaagccactgatGaaacaggctcccccttggaa	8	12	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:64415153G>A	uc001jmd.1	+	4	487	c.153G>A	c.(151-153)ATG>ATA	p.M51I	ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	51										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGCCACTGATGAAACAGGCTC	0.468													0	0	0	0.00245	0	11	40										A	64415153	G	A	64415153	3	1	6	1	0	0	0	0	1	0	0	0	17866	1290	45	1	1641	1	ZNF365	10	64415153	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	437167	64415153	71119594	390	1103										
PRF1	5551	broad.mit.edu	37	chr10	72360406	72360406	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgccagaggcaggcgctggaGggtgccctcctgtagggcat	17	12	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:72360406G>C	uc009xqg.2	-	2	414	c.253C>G	c.(253-255)CTC>GTC	p.L85V	PRF1_uc001jrf.3_Missense_Mutation_p.L85V	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	85	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						AGGCGCTGGAGGGTGCCCTCC	0.667			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.001168	0	3	28										C	72360406	G	C	72360406	3	2	6	1	0	0	0	0	1	0	0	0	12478	1000	35	4	1422	4	PRF1	10	72360406	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7945253	72360406	63174341	391	1104										
SLC29A3	55315	broad.mit.edu	37	chr10	73122191	73122191	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gatgtgtaccccgcactcctCagctccctgctggggctcag	11	16	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:73122191C>T	uc001jrr.3	+	6	1311	c.1254C>T	c.(1252-1254)CTC>CTT	p.L418L	SLC29A3_uc001jrs.3_3'UTR|SLC29A3_uc010qjq.1_Silent_p.L272L|SLC29A3_uc001jrt.3_Silent_p.L212L|SLC29A3_uc001jru.3_Silent_p.L230L	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	418	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CCGCACTCCTCAGCTCCCTGC	0.642													0	0	0	0.00623	0	35	111										T	73122191	C	T	73122191	2	4	6	1	0	0	0	0	0	0	0	1	14536	813	29	1		1	SLC29A3	10	73122191	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	761785	73122191	62412556	392	1105										
CAMK2G	818	broad.mit.edu	37	chr10	75574801	75574801	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcggtgcggcaggggcccctGagcagtgatagtggacattg	18	9	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:75574801G>A	uc001jvm.1	-	20	1762	c.1643C>T	c.(1642-1644)TCA>TTA	p.S548L	CAMK2G_uc001jvo.1_Missense_Mutation_p.S519L|CAMK2G_uc001jvq.1_Missense_Mutation_p.S496L|CAMK2G_uc001jvr.1_Missense_Mutation_p.S487L|CAMK2G_uc001jvp.1_Missense_Mutation_p.S510L|CAMK2G_uc001jvs.1_Missense_Mutation_p.S531L|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Missense_Mutation_p.S488L|CAMK2G_uc009xrp.1_Missense_Mutation_p.S137L	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	550					insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					AGGGGCCCCTGAGCAGTGATA	0.657													0	0	0	0.010729	0	10	19										A	75574801	G	A	75574801	3	1	6	1	0	0	0	0	1	0	0	0	2602	1294	45	1	31	1	CAMK2G	10	75574801	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2452610	75574801	59959946	393	1106										
CAMK2G	818	broad.mit.edu	37	chr10	75574821	75574821	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagcagtgatagtggacattGagccacttgccatcccgacg	12	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:75574821G>C	uc001jvm.1	-	20	1742	c.1623C>G	c.(1621-1623)CTC>CTG	p.L541L	CAMK2G_uc001jvo.1_Silent_p.L512L|CAMK2G_uc001jvq.1_Silent_p.L489L|CAMK2G_uc001jvr.1_Silent_p.L480L|CAMK2G_uc001jvp.1_Silent_p.L503L|CAMK2G_uc001jvs.1_Silent_p.L524L|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Silent_p.L481L|CAMK2G_uc009xrp.1_Silent_p.L130L	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	543					insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					AGTGGACATTGAGCCACTTGC	0.662													0	0	0	0.00245	0	13	27										C	75574821	G	C	75574821	2	2	6	1	0	0	0	0	0	0	0	1	2602	1277	45	1		1	CAMK2G	10	75574821	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	20	75574821	59959926	394	1107										
LRIT2	340745	broad.mit.edu	37	chr10	85984808	85984808	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aattttcaattctcacttgcTtgaactcttcagaaaggttc	5	9	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:85984808T>G	uc001kcy.2	-	2	181	c.173A>C	c.(172-174)AAG>ACG	p.K58T	LRIT2_uc010qmc.1_Missense_Mutation_p.K58T	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	58						integral to membrane				ovary(2)	2						TCTCACTTGCTTGAACTCTTC	0.418													0	0	0	0.010818	0	30	126										G	85984808	T	G	85984808	3	3	6	1	0	0	0	0	1	0	0	0	8948	1609	56	5	1487	5	LRIT2	10	85984808	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	10409987	85984808	49549939	395	1108										
TNKS2	80351	broad.mit.edu	37	chr10	93572839	93572839	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcctcttcataatgcatgctCttttggtcatgctgaagtag	8	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:93572839C>G	uc001khp.2	+	2	596	c.299C>G	c.(298-300)TCT>TGT	p.S100C		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	100	ANK 2.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				AATGCATGCTCTTTTGGTCAT	0.443													0	0	0	0.003954	0	26	116										G	93572839	C	G	93572839	3	3	6	1	0	0	0	0	1	0	0	0	16318	913	32	1	305	1	TNKS2	10	93572839	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7588031	93572839	41961908	396	1109										
KIF11	3832	broad.mit.edu	37	chr10	94405256	94405256	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagaatctgtgaaacactctGataaactcaatggcaacctg	7	9	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:94405256G>A	uc001kic.2	+	18	2712	c.2404G>A	c.(2404-2406)GAT>AAT	p.D802N	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	802					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						GAAACACTCTGATAAACTCAA	0.363													0	0	0	0.006122	0	17	84										A	94405256	G	A	94405256	3	1	6	1	0	0	0	0	1	0	0	0	8272	1290	45	1	2474	1	KIF11	10	94405256	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	832417	94405256	41129491	397	1110										
MYOF	26509	broad.mit.edu	37	chr10	95132825	95132827	+	In_Frame_Del	DEL	AGG	AGG	-													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcatccagatgatgatgtcAggcatgctgttctgtggctg							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:95132825_95132827delAGG	uc001kin.2	-	24	2440_2442	c.2317_2319delCCT	c.(2317-2319)CCTdel	p.P773del	MYOF_uc001kio.2_In_Frame_Del_p.P760del|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	773	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TGATGATGTCAGGCATGCTGTTC	0.537																		20	118	---	---								-	95132827	AGG	-	95132825	7	5	6	1	0	1	0	1	0	0	0	0	10089	175	7	0	3990	0	MYOF	10	95132825	In_Frame_Del	DEL	AGG	TCGA-BT-A0YX-01A-11D-A10S-08	727569	95132825	40401922	398	1111										
CYP2C19	1557	broad.mit.edu	37	chr10	96540313	96540313	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccctgcaatgtgatctgctCcattattttccagaaacgtt	6	11	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:96540313C>T	uc010qnz.1	+	4	539	c.539C>T	c.(538-540)TCC>TTC	p.S180F	CYP2C19_uc009xus.1_Missense_Mutation_p.S45F|CYP2C19_uc010qny.1_Missense_Mutation_p.S158F	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	180					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GTGATCTGCTCCATTATTTTC	0.373													0	0	0	0.01441	0	57	184										T	96540313	C	T	96540313	3	4	6	1	0	0	0	0	1	0	0	0	4166	855	30	1	553	1	CYP2C19	10	96540313	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1407488	96540313	38994434	399	1112										
LCOR	84458	broad.mit.edu	37	chr10	98715053	98715053	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgaccttccttttcttgcaGaaaactctgcctttccaaaa	5	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:98715053G>A	uc001kms.1	+	8	1197	c.676G>A	c.(676-678)GAA>AAA	p.E226K	LCOR_uc001kmr.2_Missense_Mutation_p.E226K|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Missense_Mutation_p.E226K|LCOR_uc001kmu.1_Missense_Mutation_p.E226K	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	226						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		TTTTCTTGCAGAAAACTCTGC	0.433													0	0	0	0.00278	0	23	69										A	98715053	G	A	98715053	3	1	6	1	0	0	0	0	1	0	0	0	8689	943	33	1	686	1	LCOR	10	98715053	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2174740	98715053	36819694	400	1113										
ZFYVE27	118813	broad.mit.edu	37	chr10	99519006	99519006	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttttcagcccctgaagcccaGagggagactgtgtttgtgtg	13	9	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:99519006G>C	uc001koo.2	+	13	1385	c.1185G>C	c.(1183-1185)CAG>CAC	p.Q395H	ZFYVE27_uc001kon.2_Missense_Mutation_p.Q400H|ZFYVE27_uc001koq.2_Missense_Mutation_p.Q302H|ZFYVE27_uc010qpa.1_Missense_Mutation_p.Q270H|ZFYVE27_uc001kop.2_Missense_Mutation_p.Q388H|ZFYVE27_uc010qpb.1_Missense_Mutation_p.Q295H|ZFYVE27_uc010qpc.1_RNA|ZFYVE27_uc010qpd.1_Missense_Mutation_p.Q356H|ZFYVE27_uc001kol.1_Missense_Mutation_p.Q395H|ZFYVE27_uc001kom.1_Missense_Mutation_p.Q388H	NM_144588	NP_653189	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27 isoform	395	Extracellular (Potential).|FYVE-type.				cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)		CTGAAGCCCAGAGGGAGACTG	0.557											OREG0020422	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	85										C	99519006	G	C	99519006	3	2	6	1	0	0	0	0	1	0	0	0	17666	933	33	1	1246	1	ZFYVE27	10	99519006	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	803953	99519006	36015741	401	1114										
FGF8	2253	broad.mit.edu	37	chr10	103531253	103531253	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttccccttcttgttcatgcaGatgtagaggcccgtctcggc	10	13	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:103531253G>C	uc001ktp.1	-	5	548	c.378C>G	c.(376-378)ATC>ATG	p.I126M	FGF8_uc001ktq.1_Missense_Mutation_p.I137M|FGF8_uc001ktr.1_Missense_Mutation_p.I108M|FGF8_uc001kts.1_Missense_Mutation_p.I97M|FGF8_uc009xwr.1_Missense_Mutation_p.I33M	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	126					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		TGTTCATGCAGATGTAGAGGC	0.607													0	0	0	0.00499	0	15	69										C	103531253	G	C	103531253	3	2	6	1	0	0	0	0	1	0	0	0	5858	932	33	1	331	1	FGF8	10	103531253	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4012247	103531253	32003494	402	1115										
NT5C2	22978	broad.mit.edu	37	chr10	104857052	104857052	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacatgaagcacttacatctGtatatttatagtcactgttg	6	8	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:104857052G>A	uc001kwo.2	-	11	953	c.767C>T	c.(766-768)ACA>ATA	p.T256I	NT5C2_uc010qqp.1_Missense_Mutation_p.T227I|NT5C2_uc001kwq.2_Missense_Mutation_p.T256I|NT5C2_uc001kwp.2_Missense_Mutation_p.T103I	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	256					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	ACTTACATCTGTATATTTATA	0.348													0	0	0	0.007413	0	19	99										A	104857052	G	A	104857052	3	1	6	1	0	0	0	0	1	0	0	0	10687	1377	48	2	954	2	NT5C2	10	104857052	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1325799	104857052	30677695	403	1116										
C10orf79	80217	broad.mit.edu	37	chr10	105903397	105903397	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcgttttctgtttggaaatCctggtattaccaagaaaagc	9	7	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:105903397C>T	uc001kxw.2	-	32	4061	c.3945G>A	c.(3943-3945)AGG>AGA	p.R1315R	C10orf79_uc009xxq.2_Silent_p.R594R	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1315											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		GTTTGGAAATCCTGGTATTAC	0.418													0	0	0	0.004672	0	3	27										T	105903397	C	T	105903397	2	4	6	1	0	0	0	0	0	0	0	1	1618	869	30	1		1	C10orf79	10	105903397	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1046345	105903397	29631350	404	1117										
TDRD1	56165	broad.mit.edu	37	chr10	115985891	115985891	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgcagactatggaaacattGaaaccctgcctctttgcaga	8	10	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:115985891G>A	uc001lbg.1	+	22	3244	c.3091G>A	c.(3091-3093)GAA>AAA	p.E1031K	TDRD1_uc001lbf.2_Missense_Mutation_p.E908K|TDRD1_uc001lbh.1_Missense_Mutation_p.E1018K|TDRD1_uc001lbi.1_Missense_Mutation_p.E1022K|TDRD1_uc010qsc.1_Missense_Mutation_p.E635K|TDRD1_uc001lbj.2_Missense_Mutation_p.E740K	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	1031	Tudor 4.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGGAAACATTGAAACCCTGCC	0.438													0	0	0	0.008361	0	28	67										A	115985891	G	A	115985891	3	1	6	1	0	0	0	0	1	0	0	0	15727	1291	45	1	3173	1	TDRD1	10	115985891	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	10082494	115985891	19548856	405	1118										
TRUB1	142940	broad.mit.edu	37	chr10	116702491	116702491	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gactctagacagcgcagcccGaggagttctgggtaagagat	14	9	2	2	rs143607039		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:116702491G>A	uc001lcd.2	+	2	435	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	TRUB1_uc010qsl.1_Missense_Mutation_p.R27Q	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	125					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		AGCGCAGCCCGAGGAGTTCTG	0.438													0	0	0	0.003163	0	13	52										A	116702491	G	A	116702491	3	1	6	1	0	0	0	0	1	0	0	0	16599	1058	37	1	380	1	TRUB1	10	116702491	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	716600	116702491	18832256	406	1119										
EIF3A	8661	broad.mit.edu	37	chr10	120809348	120809348	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actatcgccaagtcttctctCttcctctctacgccgttctc	4	17	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:120809348C>G	uc001ldu.2	-	17	2769	c.2623G>C	c.(2623-2625)GAG>CAG	p.E875Q	EIF3A_uc010qsu.1_Missense_Mutation_p.E841Q|EIF3A_uc009xzg.1_5'UTR	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	875	Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AGTCTTCTCTCTTCCTCTCTA	0.358													0	0	0	0.01441	0	81	227										G	120809348	C	G	120809348	3	3	6	1	0	0	0	0	1	0	0	0	5012	922	32	1	1549	1	EIF3A	10	120809348	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4106857	120809348	14725399	407	1120										
PLEKHA1	59338	broad.mit.edu	37	chr10	124152833	124152833	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gataccagagaagatagtttCgtgtggtacatggataatcc	11	6	0	2	rs142005373		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:124152833C>T	uc001lge.1	+	2	240	c.117C>T	c.(115-117)TTC>TTT	p.F39F	PLEKHA1_uc001lgf.1_Silent_p.F39F|PLEKHA1_uc001lgg.1_Silent_p.F39F|PLEKHA1_uc001lgh.2_Silent_p.F39F	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	39	PH 1.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AAGATAGTTTCGTGTGGTACA	0.343													0	0	0	0.014323	0	22	73										T	124152833	C	T	124152833	2	4	6	1	0	0	0	0	0	0	0	1	12055	883	31	1		1	PLEKHA1	10	124152833	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3343485	124152833	11381914	408	1121										
DMBT1	1755	broad.mit.edu	37	chr10	124358515	124358515	+	Missense_Mutation	SNP	G	G	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cattgtcctggatgatgtgcGctgctcaggacacgagtctt							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:124358515G>T	uc001lgk.1	+	26	3288	c.3182G>T	c.(3181-3183)CGC>CTC	p.R1061L	DMBT1_uc001lgl.1_Missense_Mutation_p.R1051L|DMBT1_uc001lgm.1_Missense_Mutation_p.R562L|DMBT1_uc009xzz.1_Missense_Mutation_p.R1061L|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Missense_Mutation_p.R22L	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1061	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GATGATGTGCGCTGCTCAGGA	0.592													1	0	1.51926e-22	0.01441	1.57703e-22	51	151										T	124358515	G	T	124358515	3	4	6	1	0	0	0	0	1	0	0	0	4577	1087	38	4	3284	4	DMBT1	10	124358515	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	205682	124358515	11176232	409	1122	4	2								
DMBT1	1755	broad.mit.edu	37	chr10	124358521	124358521	+	Nonsense_Mutation	SNP	C	C	G													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctggatgatgtgcgctgctCaggacacgagtcttacctgt							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:124358521C>G	uc001lgk.1	+	26	3294	c.3188C>G	c.(3187-3189)TCA>TGA	p.S1063*	DMBT1_uc001lgl.1_Nonsense_Mutation_p.S1053*|DMBT1_uc001lgm.1_Nonsense_Mutation_p.S564*|DMBT1_uc009xzz.1_Nonsense_Mutation_p.S1063*|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Nonsense_Mutation_p.S24*	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1063	SRCR 8.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGCGCTGCTCAGGACACGAG	0.607													0	0	0	0.007835	0	43	146										G	124358521	C	G	124358521	4	3	6	1	0	0	0	0	0	1	0	0	4577	838	29	1	3290	1	DMBT1	10	124358521	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6	124358521	11176226	410	1123	4	2								
C10orf137	26098	broad.mit.edu	37	chr10	127429114	127429114	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cataaaatgaaacttcagctGattctcaagtcatcaaaggc	6	9	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr10:127429114G>A	uc001liq.1	+	16	2357	c.2064G>A	c.(2062-2064)CTG>CTA	p.L688L	C10orf137_uc001lin.2_Silent_p.L654L|C10orf137_uc001lio.1_Silent_p.L654L|C10orf137_uc001lip.1_Silent_p.L392L|C10orf137_uc001lir.2_Silent_p.L182L|C10orf137_uc001lis.1_Silent_p.L14L	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	688					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AACTTCAGCTGATTCTCAAGT	0.413													0	0	0	0.008871	0	21	92										A	127429114	G	A	127429114	2	1	6	1	0	0	0	0	0	0	0	1	1594	1277	45	1		1	C10orf137	10	127429114	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3070593	127429114	8105633	411	1124										
LRDD	55367	broad.mit.edu	37	chr11	804358	804358	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcctgcggcagcagctgcctCcagctctggcccctccaccg	10	20	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:804358C>G	uc001lro.1	-	2	173	c.31G>C	c.(31-33)GAG>CAG	p.E11Q	LRDD_uc009yck.1_5'Flank|LRDD_uc001lrk.1_Missense_Mutation_p.E11Q|LRDD_uc001lrl.1_5'UTR|LRDD_uc001lrm.1_5'UTR|LRDD_uc001lrn.1_5'UTR|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	11					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGCTGCCTCCAGCTCTGGC	0.687													0	0	0	0.001855	0	8	22										G	804358	C	G	804358	3	3	6	1	0	0	0	0	1	0	0	0	8936	864	30	1	2761	1	LRDD	11	804358	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		804358	134202158	412	1125										
IGF2	3481	broad.mit.edu	37	chr11	2154279	2154279	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcggggtcttgggtgggtaGagcaatcaggggacggtgac	21	6	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:2154279G>C	uc009yde.2	-	4	584	c.481C>G	c.(481-483)CTA>GTA	p.L161V	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Missense_Mutation_p.L161V|IGF2_uc009ydf.2_Missense_Mutation_p.L217V|IGF2_uc001lvh.2_Missense_Mutation_p.L161V|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	161					glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		TGGGTGGGTAGAGCAATCAGG	0.692													0	0	0	0.005443	0	25	98										C	2154279	G	C	2154279	3	2	6	1	0	0	0	0	1	0	0	0	7572	933	33	1	65	1	IGF2	11	2154279	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1349921	2154279	132852237	413	1126										
OR10A5	144124	broad.mit.edu	37	chr11	6867346	6867346	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accaaaggacacgggccaaaCtggctgctgcttcctggttc	11	13	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:6867346C>G	uc001met.1	+	1	433	c.433C>G	c.(433-435)CTG>GTG	p.L145V		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ACGGGCCAAACTGGCTGCTGC	0.527													0	0	0	0.01441	0	34	174										G	6867346	C	G	6867346	3	3	6	1	0	0	0	0	1	0	0	0	10893	564	20	4	435	4	OR10A5	11	6867346	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4713067	6867346	128139170	414	1127										
NLRP10	338322	broad.mit.edu	37	chr11	7981789	7981789	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agctgtagaacttcttgatgGcaagtcccaattggtagtcg	11	8	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:7981789G>A	uc001mfv.1	-	2	1387	c.1370C>T	c.(1369-1371)GCC>GTC	p.A457V		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	457	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTTCTTGATGGCAAGTCCCAA	0.493													0	0	0	0.010771	0	43	170										A	7981789	G	A	7981789	3	1	6	1	0	0	0	0	1	0	0	0	10472	1203	42	2	601	2	NLRP10	11	7981789	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1114443	7981789	127024727	415	1128										
USP47	55031	broad.mit.edu	37	chr11	11942014	11942014	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttcccgaggaactagatatGagtacttttattgatgttga	9	5	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:11942014G>A	uc001mjq.1	+	11	2014	c.1251G>A	c.(1249-1251)ATG>ATA	p.M417I	USP47_uc001mjr.2_Missense_Mutation_p.M329I|USP47_uc001mjs.2_Missense_Mutation_p.M397I	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	417					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		AACTAGATATGAGTACTTTTA	0.318													0	0	0	0.013726	0	32	86										A	11942014	G	A	11942014	3	1	6	1	0	0	0	0	1	0	0	0	17075	1290	45	1	1021	1	USP47	11	11942014	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3960225	11942014	123064502	416	1129										
ZNF408	79797	broad.mit.edu	37	chr11	46727044	46727044	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accaagctgcggcgccacctCaaatctcacttggaggacaa	9	14	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:46727044C>G	uc001nde.1	+	5	2024	c.1794C>G	c.(1792-1794)CTC>CTG	p.L598L	ZNF408_uc010rgw.1_Silent_p.L590L	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	598	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GGCGCCACCTCAAATCTCACT	0.667													0	0	0	0.00499	0	18	50										G	46727044	C	G	46727044	2	3	6	1	0	0	0	0	0	0	0	1	17885	813	29	1		1	ZNF408	11	46727044	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	34785030	46727044	88279472	417	1130										
FNBP4	23360	broad.mit.edu	37	chr11	47752962	47752962	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggattctgttgaatttgaatCagtgccagttttgtctttca	9	6	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:47752962C>G	uc009ylv.2	-	12	2125	c.1972G>C	c.(1972-1974)GAT>CAT	p.D658H	FNBP4_uc001ngj.2_Missense_Mutation_p.D565H|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	658										ovary(1)	1						GAATTTGAATCAGTGCCAGTT	0.373													0	0	0	0.01441	0	51	136										G	47752962	C	G	47752962	3	3	6	1	0	0	0	0	1	0	0	0	5967	826	29	1	1105	1	FNBP4	11	47752962	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1025918	47752962	87253554	418	1131										
FNBP4	23360	broad.mit.edu	37	chr11	47753046	47753046	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctttcttcttcttcctcttCaccatctggaaactcccact	3	16	6	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:47753046C>T	uc009ylv.2	-	12	2041	c.1888G>A	c.(1888-1890)GAA>AAA	p.E630K	FNBP4_uc001ngj.2_Missense_Mutation_p.E537K|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	630	Poly-Glu.									ovary(1)	1						TCTTCCTCTTCACCATCTGGA	0.393													0	0	0	0.013114	0	46	163										T	47753046	C	T	47753046	3	4	6	1	0	0	0	0	1	0	0	0	5967	835	29	1	1189	1	FNBP4	11	47753046	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	84	47753046	87253470	419	1132										
NUP160	23279	broad.mit.edu	37	chr11	47858484	47858484	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgatcctgacacaaagcaaaGatgaaggcatcatgctccac	8	11	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:47858484G>A	uc001ngm.2	-	6	982	c.897C>T	c.(895-897)ATC>ATT	p.I299I	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	299					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						ACAAAGCAAAGATGAAGGCAT	0.408													0	0	0	0.006122	0	19	95										A	47858484	G	A	47858484	2	1	6	1	0	0	0	0	0	0	0	1	10757	932	33	1		1	NUP160	11	47858484	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	105438	47858484	87148032	420	1133										
OR5L2	26338	broad.mit.edu	37	chr11	55594852	55594852	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcactgattcaggtcagctCtcggctccacacccccgtgt	9	16	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:55594852C>T	uc001nhy.1	+	1	158	c.158C>T	c.(157-159)TCT>TTT	p.S53F		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CAGGTCAGCTCTCGGCTCCAC	0.478										HNSCC(27;0.073)			0	0	0	0.01441	0	99	289										T	55594852	C	T	55594852	3	4	6	1	0	0	0	0	1	0	0	0	11171	913	32	1	160	1	OR5L2	11	55594852	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7736368	55594852	79411664	421	1134										
OR5AK2	390181	broad.mit.edu	37	chr11	56757051	56757051	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcttttcctacatctacatCatggccaccatcctgaaaat	3	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:56757051C>T	uc010rjp.1	+	1	663	c.663C>T	c.(661-663)ATC>ATT	p.I221I		NM_001005323	NP_001005323	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						ACATCTACATCATGGCCACCA	0.438													0	0	0	0.01441	0	53	196										T	56757051	C	T	56757051	2	4	6	1	0	0	0	0	0	0	0	1	11142	816	29	1		1	OR5AK2	11	56757051	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1162199	56757051	78249465	422	1135										
PRG2	5553	broad.mit.edu	37	chr11	57156683	57156683	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agagccccactcctcctcttCctccagctccctgcaagggg	8	19	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:57156683C>T	uc001njz.2	-	2	193	c.166G>A	c.(166-168)GAA>AAA	p.E56K	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.E56K|PRG2_uc001nkb.2_Missense_Mutation_p.E56K|PRG2_uc001nkd.2_Missense_Mutation_p.E56K|PRG2_uc001nkc.2_Missense_Mutation_p.E56K|PRG2_uc001nke.2_Missense_Mutation_p.E336K	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	56					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	TCCTCCTCTTCCTCCAGCTCC	0.547													0	0	0	0.003954	0	27	82										T	57156683	C	T	57156683	3	4	6	1	0	0	0	0	1	0	0	0	12479	864	30	1	518	1	PRG2	11	57156683	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	399632	57156683	77849833	423	1136										
GLYATL1	92292	broad.mit.edu	37	chr11	58723268	58723268	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgggtaaccatggacccttCttgtgaagtaggaatggcct	12	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:58723268C>T	uc001nnf.2	+	8	1053	c.677C>T	c.(676-678)TCT>TTT	p.S226F	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.S257F|GLYATL1_uc001nni.1_Missense_Mutation_p.S226F|GLYATL1_uc001nnj.1_Missense_Mutation_p.S226F			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	226						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	ATGGACCCTTCTTGTGAAGTA	0.517													0	0	0	0.008871	0	20	44										T	58723268	C	T	58723268	3	4	6	1	0	0	0	0	1	0	0	0	6480	913	32	1	796	1	GLYATL1	11	58723268	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1566585	58723268	76283248	424	1137										
CCDC86	79080	broad.mit.edu	37	chr11	60610305	60610305	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaggagcttcctgtaatcccGaaggggaagcccaaatcggg	14	10	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:60610305G>A	uc001nqa.2	+	1	877	c.708G>A	c.(706-708)CCG>CCA	p.P236P	CCDC86_uc001nqb.2_5'UTR	NM_024098	NP_077003	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	236					interspecies interaction between organisms	nucleus					0						CTGTAATCCCGAAGGGGAAGC	0.567													0	0	0	0.008291	0	9	35										A	60610305	G	A	60610305	2	1	6	1	0	0	0	0	0	0	0	1	2861	1045	37	1		1	CCDC86	11	60610305	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1887037	60610305	74396211	425	1138										
FADS3	3995	broad.mit.edu	37	chr11	61644427	61644427	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcatagaagctggcggcccaGagcaaatcctgcagaggagg	15	10	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:61644427G>C	uc001nsm.2	-	8	1047	c.894C>G	c.(892-894)CTC>CTG	p.L298L	FADS3_uc001nsn.2_Silent_p.L174L	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	298	Lumenal (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						TGGCGGCCCAGAGCAAATCCT	0.557													0	0	0	0.004672	0	3	10										C	61644427	G	C	61644427	2	2	6	1	0	0	0	0	0	0	0	1	5367	929	33	1		1	FADS3	11	61644427	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1034122	61644427	73362089	426	1139										
AHNAK	79026	broad.mit.edu	37	chr11	62288785	62288785	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcttgaactttggacccttGagttttgcatctggaccttc	8	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:62288785G>C	uc001ntl.2	-	5	13404	c.13104C>G	c.(13102-13104)CTC>CTG	p.L4368L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4368					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTGGACCCTTGAGTTTTGCAT	0.468													0	0	0	0.01441	0	55	202										C	62288785	G	C	62288785	2	2	6	1	0	0	0	0	0	0	0	1	414	1277	45	1		1	AHNAK	11	62288785	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	644358	62288785	72717731	427	1140										
B3GAT3	26229	broad.mit.edu	37	chr11	62384199	62384199	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacccggccgtcctgtacctGagggccctcgaatcgcaggc	12	16	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:62384199G>C	uc001ntw.2	-	4	717	c.688C>G	c.(688-690)CAG>GAG	p.Q230E	B3GAT3_uc009ynz.2_Missense_Mutation_p.Q223E|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Missense_Mutation_p.Q230E	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	230	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						TCCTGTACCTGAGGGCCCTCG	0.647													0	0	0	0.00308	0	7	21										C	62384199	G	C	62384199	3	2	6	1	0	0	0	0	1	0	0	0	1255	1299	45	1	327	1	B3GAT3	11	62384199	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	95414	62384199	72622317	428	1141										
MAP4K2	5871	broad.mit.edu	37	chr11	64564578	64564578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actgtagcaccctcttacctCaggatcctcccgctgcttca	6	17	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:64564578C>T	uc001obh.2	-	19	1455	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K	MAP4K2_uc001obg.2_5'Flank|MAP4K2_uc001obi.2_Missense_Mutation_p.E447K	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	455					activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CCTCTTACCTCAGGATCCTCC	0.657													0	0	0	0.008291	0	9	62										T	64564578	C	T	64564578	3	4	6	1	0	0	0	0	1	0	0	0	9260	835	29	1	1155	1	MAP4K2	11	64564578	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2180379	64564578	70441938	429	1142										
FAM89B	23625	broad.mit.edu	37	chr11	65340999	65340999	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cggatgcgggcctgtctgacGacgaggagcctcccgatgcc	15	14	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:65340999G>A	uc001oem.2	+	2	739	c.418G>A	c.(418-420)GAC>AAC	p.D140N	FAM89B_uc001oen.2_3'UTR|FAM89B_uc001oel.2_Missense_Mutation_p.D153N|EHBP1L1_uc001oeo.3_5'Flank	NM_152832	NP_690045	Q8N5H3	FA89B_HUMAN	family with sequence similarity 89, member B	140											0						CCTGTCTGACGACGAGGAGCC	0.632													0	0	0	0.012319	0	18	49										A	65340999	G	A	65340999	3	1	6	1	0	0	0	0	1	0	0	0	5648	1058	37	1	473	1	FAM89B	11	65340999	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	776421	65340999	69665517	430	1143										
FAM89B	23625	broad.mit.edu	37	chr11	65341111	65341111	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgccttccacatcagcctctGaagggctggggggcaggggg	17	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:65341111G>A	uc001oem.2	+	2	851	c.530G>A	c.(529-531)TGA>TAA	p.*177*	FAM89B_uc001oen.2_3'UTR|FAM89B_uc001oel.2_Silent_p.*190*|EHBP1L1_uc001oeo.3_5'Flank	NM_152832	NP_690045	Q8N5H3	FA89B_HUMAN	family with sequence similarity 89, member B	177											0						ATCAGCCTCTGAAGGGCTGGG	0.662													0	0	0	0.010729	0	6	45										A	65341111	G	A	65341111	2	1	6	1	0	0	0	0	0	0	0	1	5648	1285	45	1		1	FAM89B	11	65341111	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	112	65341111	69665405	431	1144										
PACS1	55690	broad.mit.edu	37	chr11	65983668	65983668	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgtctctgtgcctgtggcaGaaataaagatctactccctg	9	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:65983668G>C	uc001oha.1	+	5	873	c.739G>C	c.(739-741)GAA>CAA	p.E247Q	PACS1_uc001ogz.1_Missense_Mutation_p.E247Q	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	247					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						GCCTGTGGCAGAAATAAAGAT	0.517													0	0	0	0.003954	0	24	69										C	65983668	G	C	65983668	3	2	6	1	0	0	0	0	1	0	0	0	11372	943	33	1	757	1	PACS1	11	65983668	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	642557	65983668	69022848	432	1145										
SPTBN2	6712	broad.mit.edu	37	chr11	66460711	66460711	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgctcgcccatccaggcctcCgcctcggcggcatcgcggta	12	18	0	0	rs146007976	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:66460711C>T	uc001ojd.2	-	23	4872	c.4800G>A	c.(4798-4800)GCG>GCA	p.A1600A		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1600	Spectrin 13.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCCAGGCCTCCGCCTCGGCGG	0.622													0	0	0	0.013726	0	34	101										T	66460711	C	T	66460711	2	4	6	1	0	0	0	0	0	0	0	1	15119	639	23	2		2	SPTBN2	11	66460711	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	477043	66460711	68545805	433	1146										
CLCF1	23529	broad.mit.edu	37	chr11	67133035	67133035	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtcaacagtggccctgggcaGagtctctgcccccaggcggg	15	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:67133035G>C	uc001okq.2	-	3	446	c.250C>G	c.(250-252)CTG>GTG	p.L84V	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Missense_Mutation_p.L74V	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	84					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			GCCCTGGGCAGAGTCTCTGCC	0.587													0	0	0	0.013726	0	33	112										C	67133035	G	C	67133035	3	2	6	1	0	0	0	0	1	0	0	0	3461	933	33	1	431	1	CLCF1	11	67133035	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	672324	67133035	67873481	434	1147										
PPP1CA	5499	broad.mit.edu	37	chr11	67166318	67166318	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcaaagaactcgtagccgtCttctaccacctgggcgagga							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:67166318C>T	uc001okw.1	-	6	880	c.757G>A	c.(757-759)GAC>AAC	p.D253N	PPP1CA_uc009yro.1_Missense_Mutation_p.D71N|PPP1CA_uc001okt.1_Missense_Mutation_p.D258N|PPP1CA_uc001oku.1_Missense_Mutation_p.D264N|PPP1CA_uc001okv.1_Missense_Mutation_p.D209N|PPP1CA_uc001okx.1_Missense_Mutation_p.D341N|PPP1CA_uc001oky.2_Missense_Mutation_p.D253N	NM_002708	NP_002699	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha	253					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			TCGTAGCCGTCTTCTACCACC	0.627													0	0	0	0.00623	0	33	84										T	67166318	C	T	67166318	3	4	6	1	0	0	0	0	1	0	0	0	12349	913	32	1	243	1	PPP1CA	11	67166318	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	33283	67166318	67840198	435	1148	5	2								
PPP1CA	5499	broad.mit.edu	37	chr11	67166321	67166321	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaagaactcgtagccgtcttCtaccacctgggcgaggatgg							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:67166321C>T	uc001okw.1	-	6	877	c.754G>A	c.(754-756)GAA>AAA	p.E252K	PPP1CA_uc009yro.1_Missense_Mutation_p.E70K|PPP1CA_uc001okt.1_Missense_Mutation_p.E257K|PPP1CA_uc001oku.1_Missense_Mutation_p.E263K|PPP1CA_uc001okv.1_Missense_Mutation_p.E208K|PPP1CA_uc001okx.1_Missense_Mutation_p.E340K|PPP1CA_uc001oky.2_Missense_Mutation_p.E252K	NM_002708	NP_002699	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha	252					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			TAGCCGTCTTCTACCACCTGG	0.627													0	0	0	0.00623	0	34	85										T	67166321	C	T	67166321	3	4	6	1	0	0	0	0	1	0	0	0	12349	922	32	1	246	1	PPP1CA	11	67166321	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3	67166321	67840195	436	1149	5	2								
PPP1CA	5499	broad.mit.edu	37	chr11	67166578	67166578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caggccctggtcaggcacatCtgtgggccgcatgatccgcc	13	15	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:67166578C>T	uc001okw.1	-	5	703	c.580G>A	c.(580-582)GAT>AAT	p.D194N	PPP1CA_uc009yro.1_Missense_Mutation_p.D12N|PPP1CA_uc001okt.1_Missense_Mutation_p.D199N|PPP1CA_uc001oku.1_Missense_Mutation_p.D205N|PPP1CA_uc001okv.1_Missense_Mutation_p.D150N|PPP1CA_uc001okx.1_Missense_Mutation_p.D282N|PPP1CA_uc001oky.2_Missense_Mutation_p.D194N	NM_002708	NP_002699	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha	194					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			TCAGGCACATCTGTGGGCCGC	0.622													0	0	0	0.005443	0	26	79										T	67166578	C	T	67166578	3	4	6	1	0	0	0	0	1	0	0	0	12349	913	32	1	424	1	PPP1CA	11	67166578	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	257	67166578	67839938	437	1150										
TBC1D10C	374403	broad.mit.edu	37	chr11	67172956	67172956	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggggcccatgtgtgccagaaGaacagccctggcacctatca	12	13	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:67172956G>A	uc001ola.2	+	4	368	c.339G>A	c.(337-339)AAG>AAA	p.K113K	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Silent_p.K113K|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	113	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TGTGCCAGAAGAACAGCCCTG	0.647													0	0	0	0.006122	0	17	53										A	67172956	G	A	67172956	2	1	6	1	0	0	0	0	0	0	0	1	15597	933	33	1		1	TBC1D10C	11	67172956	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6378	67172956	67833560	438	1151										
ALDH3B1	221	broad.mit.edu	37	chr11	67787235	67787235	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggagacggggcagctgctaGagcacaggttcgactacatc	14	10	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:67787235G>C	uc010rpy.1	+	7	648	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	ALDH3B1_uc001omz.2_Missense_Mutation_p.E178Q|ALDH3B1_uc001ona.2_Missense_Mutation_p.E141Q|ALDH3B1_uc001onb.2_RNA	NM_001161473	NP_001154945	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3B1 isoform a	178					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase				0					NADH(DB00157)	GCAGCTGCTAGAGCACAGGTT	0.652													0	0	0	0.010818	0	25	100										C	67787235	G	C	67787235	3	2	6	1	0	0	0	0	1	0	0	0	499	943	33	1	549	1	ALDH3B1	11	67787235	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	614279	67787235	67219281	439	1152										
FADD	8772	broad.mit.edu	37	chr11	70049613	70049613	+	Silent	SNP	G	G	A													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcggtgtcgtccagcctgtcGagcagcgagctgaccgagct							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:70049613G>A	uc001opm.2	+	1	345	c.48G>A	c.(46-48)TCG>TCA	p.S16S		NM_003824	NP_003815	Q13158	FADD_HUMAN	Fas-associated via death domain	16	DED.				activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			ovary(1)|lung(1)|pancreas(1)	3	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CCAGCCTGTCGAGCAGCGAGC	0.697													0	0	0	0.009096	0	4	14										A	70049613	G	A	70049613	2	1	6	1	0	0	0	0	0	0	0	1	5364	1045	37	1		1	FADD	11	70049613	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2262378	70049613	64956903	440	1153	6	2								
FADD	8772	broad.mit.edu	37	chr11	70049620	70049620	+	Missense_Mutation	SNP	G	G	A													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgtccagcctgtcgagcagcGagctgaccgagctcaagttc							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:70049620G>A	uc001opm.2	+	1	352	c.55G>A	c.(55-57)GAG>AAG	p.E19K		NM_003824	NP_003815	Q13158	FADD_HUMAN	Fas-associated via death domain	19	DED.				activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			ovary(1)|lung(1)|pancreas(1)	3	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GTCGAGCAGCGAGCTGACCGA	0.692													0	0	0	0.000602	0	5	15										A	70049620	G	A	70049620	3	1	6	1	0	0	0	0	1	0	0	0	5364	1059	37	1	57	1	FADD	11	70049620	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7	70049620	64956896	441	1154	6	2								
C11orf82	220042	broad.mit.edu	37	chr11	82643575	82643575	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caccttcgttactcagacttGaagagacagccagcagttcc	8	13	1	3	rs149497860		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:82643575G>C	uc001ozt.2	+	6	1439	c.1195G>C	c.(1195-1197)GAA>CAA	p.E399Q	C11orf82_uc010rsr.1_Missense_Mutation_p.E98Q|C11orf82_uc010rss.1_Missense_Mutation_p.E98Q|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	399					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						ACTCAGACTTGAAGAGACAGC	0.468													0	0	0	0.01441	0	70	221										C	82643575	G	C	82643575	3	2	6	1	0	0	0	0	1	0	0	0	1665	1291	45	1	1209	1	C11orf82	11	82643575	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	12593955	82643575	52362941	442	1155										
ME3	10873	broad.mit.edu	37	chr11	86160971	86160971	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agtccaccatccagatctttCttgtggcctctgccttcggt	8	14	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:86160971C>T	uc001pbz.2	-	9	1345	c.1091G>A	c.(1090-1092)AGA>AAA	p.R364K	ME3_uc001pca.2_Missense_Mutation_p.R364K|ME3_uc009yvk.2_Missense_Mutation_p.R364K|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	364					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	CCAGATCTTTCTTGTGGCCTC	0.522													0	0	0	0.01441	0	48	145										T	86160971	C	T	86160971	3	4	6	1	0	0	0	0	1	0	0	0	9419	913	32	1	747	1	ME3	11	86160971	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3517396	86160971	48845545	443	1156										
PIWIL4	143689	broad.mit.edu	37	chr11	94335120	94335120	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaagagttgcaggttccatgGgatttaatgtggactacccc	12	8	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:94335120G>A	uc001pfa.2	+	12	1751	c.1540G>A	c.(1540-1542)GGA>AGA	p.G514R	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	514					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGGTTCCATGGGATTTAATGT	0.378													0	0	0	0.00632	0	28	119										A	94335120	G	A	94335120	3	1	6	1	0	0	0	0	1	0	0	0	11960	1233	43	2	1586	2	PIWIL4	11	94335120	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8174149	94335120	40671396	444	1157										
YAP1	10413	broad.mit.edu	37	chr11	102100669	102100669	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaagctttcttacatggttaTagagccctcaggcagactga	9	9	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:102100669T>C	uc001pgt.2	+	9	1883	c.1513T>C	c.(1513-1515)TAG>CAG	p.*505Q	YAP1_uc001pgs.2_Nonstop_Mutation_p.*455Q|YAP1_uc001pgu.2_Nonstop_Mutation_p.*489Q|YAP1_uc001pgv.2_Nonstop_Mutation_p.*451Q|YAP1_uc010ruo.1_Nonstop_Mutation_p.*327Q|YAP1_uc001pgw.2_Nonstop_Mutation_p.*329Q|YAP1_uc010rup.1_Nonstop_Mutation_p.*270Q	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	505					cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		TACATGGTTATAGAGCCCTCA	0.433													0	0	0	0.01441	0	53	116										C	102100669	T	C	102100669	4	2	6	1	0	0	0	0	0	0	0	0	17463	1419	49	5	1559	5	YAP1	11	102100669	Nonstop_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	7765549	102100669	32905847	445	1158										
GRIA4	2893	broad.mit.edu	37	chr11	105789548	105789548	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attgcaaaacatattggtatCaagtataaaattgccattgt	6	5	1	0	rs145685023		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:105789548C>G	uc001pix.2	+	11	1826	c.1380C>G	c.(1378-1380)ATC>ATG	p.I460M	GRIA4_uc001piw.2_Missense_Mutation_p.I460M	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	460	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ATATTGGTATCAAGTATAAAA	0.353													0	0	0	0.007413	0	20	53										G	105789548	C	G	105789548	3	3	6	1	0	0	0	0	1	0	0	0	6770	816	29	1	1455	1	GRIA4	11	105789548	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3688879	105789548	29216968	446	1159										
ATM	472	broad.mit.edu	37	chr11	108160459	108160459	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actgaaagatataaaaagtgGcttaggaggagcttgggcct	13	5	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:108160459G>A	uc001pkb.1	+	29	4752	c.4367G>A	c.(4366-4368)GGC>GAC	p.G1456D	ATM_uc009yxr.1_Missense_Mutation_p.G1456D|ATM_uc001pkd.3_Missense_Mutation_p.G108D|ATM_uc001pke.1_Missense_Mutation_p.G108D|ATM_uc010rvw.1_Missense_Mutation_p.G108D|ATM_uc001pkf.2_Missense_Mutation_p.G108D	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1456					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATAAAAAGTGGCTTAGGAGGA	0.313			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.004007	0	16	62										A	108160459	G	A	108160459	3	1	6	1	0	0	0	0	1	0	0	0	1109	1203	42	2	4477	2	ATM	11	108160459	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2370911	108160459	26846057	447	1160										
PPP2R1B	5519	broad.mit.edu	37	chr11	111636995	111636995	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacgtcttcattgcggagctCgtcgattaaaaccgcgatcg	10	12	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:111636995C>T	uc001plx.1	-	1	175	c.91G>A	c.(91-93)GAG>AAG	p.E31K	PPP2R1B_uc001plw.1_Missense_Mutation_p.E31K|PPP2R1B_uc010rwi.1_Missense_Mutation_p.E31K|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_Missense_Mutation_p.E31K|PPP2R1B_uc010rwl.1_Missense_Mutation_p.E31K	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	31	HEAT 1.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		TTGCGGAGCTCGTCGATTAAA	0.637													0	0	0	0.00245	0	14	69										T	111636995	C	T	111636995	3	4	6	1	0	0	0	0	1	0	0	0	12383	893	31	1	1997	1	PPP2R1B	11	111636995	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3476536	111636995	23369521	448	1161										
USP28	57646	broad.mit.edu	37	chr11	113697974	113697974	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctgtccatataaataatctGaggaaattccagcttattgt	6	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:113697974G>A	uc001poh.2	-	11	1201	c.1168C>T	c.(1168-1170)CAG>TAG	p.Q390*	USP28_uc001pog.2_Nonsense_Mutation_p.Q98*|USP28_uc010rwy.1_Nonsense_Mutation_p.Q265*|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Nonsense_Mutation_p.Q390*	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	390					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TAAATAATCTGAGGAAATTCC	0.363													0	0	0	0.00245	0	14	70										A	113697974	G	A	113697974	4	1	6	1	0	0	0	0	0	1	0	0	17055	1299	45	1	2125	1	USP28	11	113697974	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2060979	113697974	21308542	449	1162										
MLL	4297	broad.mit.edu	37	chr11	118361911	118361911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaactttgctttgctttcagGaaacttctgccctctctgtg	7	11	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:118361911G>A	uc001pta.2	+	14	4720	c.4697G>A	c.(4696-4698)GGA>GAA	p.G1566E	MLL_uc001ptb.2_Missense_Mutation_p.G1566E|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1566	PHD-type 3.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TTGCTTTCAGGAAACTTCTGC	0.418			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.013537	0	13	69										A	118361911	G	A	118361911	3	1	6	1	0	0	0	0	1	0	0	0	9620	1188	41	1	4751	1	MLL	11	118361911	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4663937	118361911	16644605	450	1163										
OR8B8	26493	broad.mit.edu	37	chr11	124310898	124310898	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagaagcctagaaacaggaaGaagagggggatctggactcc	14	7	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:124310898G>A	uc010sal.1	-	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GAAACAGGAAGAAGAGGGGGA	0.502													0	0	0	0.001855	0	13	77										A	124310898	G	A	124310898	2	1	6	1	0	0	0	0	0	0	0	1	11230	933	33	1		1	OR8B8	11	124310898	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5948987	124310898	10695618	451	1164										
PANX3	116337	broad.mit.edu	37	chr11	124482954	124482954	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggacagctcctgctgggactCactgcttcaccataagcagg	11	13	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:124482954C>A	uc001qah.2	+	2	260	c.260C>A	c.(259-261)TCA>TAA	p.S87*		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	87	Extracellular (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		TGCTGGGACTCACTGCTTCAC	0.557													1	0	1.56452e-12	0.007413	1.61141e-12	18	70										A	124482954	C	A	124482954	4	1	6	1	0	0	0	0	0	1	0	0	11422	838	29	3	266	3	PANX3	11	124482954	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	172056	124482954	10523562	452	1165										
FOXRED1	55572	broad.mit.edu	37	chr11	126139117	126139117	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggttatgattcggagggttCtgccgcacggcatgggccgg	18	9	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:126139117C>T	uc001qdi.2	+	1	63	c.16C>T	c.(16-18)CTG>TTG	p.L6L	SRPR_uc001qdh.2_5'Flank|SRPR_uc010sbm.1_5'Flank|FOXRED1_uc010sbn.1_5'UTR|FOXRED1_uc010sbo.1_RNA|FOXRED1_uc010sbp.1_5'UTR|FOXRED1_uc010sbq.1_5'UTR|FOXRED1_uc001qdj.2_5'UTR|FOXRED1_uc010sbr.1_5'UTR|FOXRED1_uc001qdk.2_5'Flank	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	6						integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		TCGGAGGGTTCTGCCGCACGG	0.617													0	0	0	0.008871	0	18	65										T	126139117	C	T	126139117	2	4	6	1	0	0	0	0	0	0	0	1	6033	912	32	1		1	FOXRED1	11	126139117	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1656163	126139117	8867399	453	1166										
KCNJ5	3762	broad.mit.edu	37	chr11	128781855	128781855	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gacctccgcaactcccacatCgtggaggcctccatccgggc	10	18	0	0	rs149327599		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:128781855C>T	uc001qet.2	+	2	1001	c.687C>T	c.(685-687)ATC>ATT	p.I229I	KCNJ5_uc009zck.2_Silent_p.I229I|KCNJ5_uc001qew.2_Silent_p.I229I	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	229	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	ACTCCCACATCGTGGAGGCCT	0.592													0	0	0	0.00623	0	38	119										T	128781855	C	T	128781855	2	4	6	1	0	0	0	0	0	0	0	1	8054	874	31	1		1	KCNJ5	11	128781855	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2642738	128781855	6224661	454	1167										
NCAPD3	23310	broad.mit.edu	37	chr11	134064592	134064592	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttcctaacgttggtcttctCatccctgatcctccttctca	4	16	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr11:134064592C>T	uc001qhd.1	-	14	2263	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	553	HEAT 2.				cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TTGGTCTTCTCATCCCTGATC	0.418													0	0	0	0.00245	0	14	79										T	134064592	C	T	134064592	3	4	6	1	0	0	0	0	1	0	0	0	10206	835	29	1	2927	1	NCAPD3	11	134064592	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5282737	134064592	941924	455	1168										
WNK1	65125	broad.mit.edu	37	chr12	936320	936320	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctccacctatcattcaccgcGatcttaaatgtgacaacatc	4	14	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:936320G>A	uc001qio.3	+	3	1552	c.1045G>A	c.(1045-1047)GAT>AAT	p.D349N	WNK1_uc001qin.2_Missense_Mutation_p.D349N|WNK1_uc001qip.3_Missense_Mutation_p.D349N	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	349	Protein kinase.	Proton acceptor (By similarity).			intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CATTCACCGCGATCTTAAATG	0.463													0	0	0	0.01441	0	69	225										A	936320	G	A	936320	3	1	6	1	0	0	0	0	1	0	0	0	17374	1058	37	1	1055	1	WNK1	12	936320	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		936320	132915575	456	1169										
KCNA1	3736	broad.mit.edu	37	chr12	5020928	5020928	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgggcgaggaggccatggaGaagttccgggaggacgaggg	21	6	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:5020928G>A	uc001qnh.2	+	2	1489	c.384G>A	c.(382-384)GAG>GAA	p.E128E		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	128					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGGCCATGGAGAAGTTCCGGG	0.632													0	0	0	0.006122	0	18	77										A	5020928	G	A	5020928	2	1	6	1	0	0	0	0	0	0	0	1	8001	933	33	1		1	KCNA1	12	5020928	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4084608	5020928	128830967	457	1170										
CHD4	1108	broad.mit.edu	37	chr12	6690250	6690250	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggttcctctgttctctccttCacctctgccttttccacttt	4	16	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:6690250C>G	uc001qpo.2	-	33	5033	c.4869G>C	c.(4867-4869)GTG>GTC	p.V1623V	CHD4_uc001qpn.2_Silent_p.V1616V|CHD4_uc001qpp.2_Silent_p.V1648V|uc001qpq.1_Intron	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1623	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TTCTCTCCTTCACCTCTGCCT	0.403													0	0	0	0.01441	0	103	357										G	6690250	C	G	6690250	2	3	6	1	0	0	0	0	0	0	0	1	3327	813	29	1		1	CHD4	12	6690250	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1669322	6690250	127161645	458	1171										
LST-3TM12	338821	broad.mit.edu	37	chr12	21200106	21200106	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttatatcattaaaatggtgGagcaacagtatggttggtct	10	5	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:21200106G>C	uc010sin.1	+	7	949	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.E364Q	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	317						membrane	transporter activity				0						TAAAATGGTGGAGCAACAGTA	0.338													0	0	0	0.006214	0	9	25										C	21200106	G	C	21200106	3	2	6	1	0	0	0	0	1	0	0	0	9066	1175	41	1	975	1	LST-3TM12	12	21200106	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14509856	21200106	112651789	459	1172										
C12orf39	80763	broad.mit.edu	37	chr12	21680080	21680080	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggctatagagactgttggaGagaaggaactggactcctca	14	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:21680080G>A	uc001rfa.1	+	3	250	c.99G>A	c.(97-99)GAG>GAA	p.E33E	C12orf39_uc009ziv.1_5'Flank|C12orf39_uc009ziw.1_5'Flank	NM_030572	NP_085049	Q9BT56	SPXN_HUMAN	spexin precursor	33						extracellular region|nucleus|transport vesicle					0						GACTGTTGGAGAGAAGGAACT	0.433													0	0	0	0.003271	0	34	133										A	21680080	G	A	21680080	2	1	6	1	0	0	0	0	0	0	0	1	1684	933	33	1		1	C12orf39	12	21680080	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	479974	21680080	112171815	460	1173										
C12orf11	55726	broad.mit.edu	37	chr12	27066551	27066551	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccaagactctttgatgtttCtctgagttgttgatatgggc	10	7	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:27066551C>T	uc001rhk.3	-	14	2181	c.1644G>A	c.(1642-1644)GAG>GAA	p.E548E	C12orf11_uc001rhj.3_Silent_p.E116E|C12orf11_uc010sjk.1_Silent_p.E447E	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	548					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					TTTGATGTTTCTCTGAGTTGT	0.418													0	0	0	0.01441	0	115	375										T	27066551	C	T	27066551	2	4	6	1	0	0	0	0	0	0	0	1	1675	912	32	1		1	C12orf11	12	27066551	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5386471	27066551	106785344	461	1174										
FGD4	121512	broad.mit.edu	37	chr12	32735372	32735372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggaaagccctctggaactgGagcagctggaccagcaccat	13	12	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:32735372G>A	uc001rkz.2	+	4	1048	c.571G>A	c.(571-573)GAG>AAG	p.E191K	FGD4_uc001rlc.2_Missense_Mutation_p.E276K|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.E303K|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Missense_Mutation_p.E191K	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	191					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TCTGGAACTGGAGCAGCTGGA	0.498													0	0	0	0.003163	0	14	75										A	32735372	G	A	32735372	3	1	6	1	0	0	0	0	1	0	0	0	5835	1175	41	1	577	1	FGD4	12	32735372	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5668821	32735372	101116523	462	1175										
LRRK2	120892	broad.mit.edu	37	chr12	40753217	40753217	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctaatgatttcaccattcaGaaactcattgagacaagaac	5	9	4	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:40753217G>C	uc001rmg.3	+	47	7120	c.6999G>C	c.(6997-6999)CAG>CAC	p.Q2333H	LRRK2_uc009zjw.2_Missense_Mutation_p.Q1171H|LRRK2_uc001rmi.2_Missense_Mutation_p.Q1166H	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2333					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCACCATTCAGAAACTCATTG	0.303													0	0	0	0.006122	0	16	64										C	40753217	G	C	40753217	3	2	6	1	0	0	0	0	1	0	0	0	9033	933	33	1	7185	1	LRRK2	12	40753217	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8017845	40753217	93098678	463	1176										
COL2A1	1280	broad.mit.edu	37	chr12	48369179	48369179	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgggagccctcggggctgcgGatgctctcaatctggttgtt	15	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:48369179G>A	uc001rqu.2	-	51	3988	c.3807C>T	c.(3805-3807)ATC>ATT	p.I1269I	COL2A1_uc001rqt.2_Silent_p.I50I|COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Silent_p.I1200I	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	1269	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CGGGGCTGCGGATGCTCTCAA	0.607													0	0	0	0.003954	0	25	91										A	48369179	G	A	48369179	2	1	6	1	0	0	0	0	0	0	0	1	3687	1164	41	1		1	COL2A1	12	48369179	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7615962	48369179	85482716	464	1177										
ADCY6	112	broad.mit.edu	37	chr12	49176905	49176905	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caccgcgtcgggcgccacctCagccgtcccgcccgctgtcg	12	21	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:49176905C>T	uc001rsh.3	-	1	973	c.313G>A	c.(313-315)GAG>AAG	p.E105K	ADCY6_uc001rsj.3_Missense_Mutation_p.E105K|ADCY6_uc001rsi.3_Missense_Mutation_p.E105K	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	105	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						GGCGCCACCTCAGCCGTCCCG	0.711													0	0	0	0.00333	0	22	89										T	49176905	C	T	49176905	3	4	6	1	0	0	0	0	1	0	0	0	298	835	29	1	3277	1	ADCY6	12	49176905	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	807726	49176905	84674990	465	1178										
DDX23	9416	broad.mit.edu	37	chr12	49228219	49228219	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtctcttcctcaatctgttGagccaactcacgggtgggag	12	11	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:49228219G>C	uc001rsm.2	-	12	1535	c.1444C>G	c.(1444-1446)CAA>GAA	p.Q482E		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	482	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TCAATCTGTTGAGCCAACTCA	0.547													0	0	0	0.005524	0	33	110										C	49228219	G	C	49228219	3	2	6	1	0	0	0	0	1	0	0	0	4350	1299	45	1	1042	1	DDX23	12	49228219	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	51314	49228219	84623676	466	1179										
DDX23	9416	broad.mit.edu	37	chr12	49231850	49231850	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagcctctcgttctgctttaGagaggaacttgggctacaaa	10	10	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:49231850G>C	uc001rsm.2	-	6	585	c.494C>G	c.(493-495)TCT>TGT	p.S165C		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	165	Glu-rich.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TTCTGCTTTAGAGAGGAACTT	0.498													0	0	0	0.007835	0	39	164										C	49231850	G	C	49231850	3	2	6	1	0	0	0	0	1	0	0	0	4350	942	33	1	2016	1	DDX23	12	49231850	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3631	49231850	84620045	467	1180										
MLL2	8085	broad.mit.edu	37	chr12	49434415	49434415	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgaggagtcaatgggggctGagcatatgggtcagtgtagg	18	6	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:49434415G>A	uc001rta.3	-	31	7138	c.7138C>T	c.(7138-7140)CAG>TAG	p.Q2380*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2380	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AATGGGGGCTGAGCATATGGG	0.652			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.012319	0	19	41										A	49434415	G	A	49434415	4	1	6	1	0	0	0	0	0	1	0	0	9621	1299	45	1	9571	1	MLL2	12	49434415	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	202565	49434415	84417480	468	1181										
SPRYD3	84926	broad.mit.edu	37	chr12	53460151	53460151	+	Missense_Mutation	SNP	C	C	G													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcttccccatcctcttcctCttcctcttcctcctcttcct							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:53460151C>G	uc001sbt.1	-	10	1162	c.1141G>C	c.(1141-1143)GAG>CAG	p.E381Q		NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	381	Glu-rich.									central_nervous_system(1)	1						tcctcttcctcttcctcttcc	0.443											OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	24	73										G	53460151	C	G	53460151	3	3	6	1	0	0	0	0	1	0	0	0	15108	922	32	1	195	1	SPRYD3	12	53460151	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4025736	53460151	80391744	469	1182	7	2								
SPRYD3	84926	broad.mit.edu	37	chr12	53460160	53460160	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcctcttcctcttcctcttCctcctcttcctcttcccctt							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:53460160C>T	uc001sbt.1	-	10	1153	c.1132G>A	c.(1132-1134)GAA>AAA	p.E378K		NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	378	Glu-rich.									central_nervous_system(1)	1						tcttcctcttcctcctcttcc	0.428											OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012319	0	21	71										T	53460160	C	T	53460160	3	4	6	1	0	0	0	0	1	0	0	0	15108	864	30	1	204	1	SPRYD3	12	53460160	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	9	53460160	80391735	470	1183	7	2								
ATF7	11016	broad.mit.edu	37	chr12	53911120	53911120	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctggagaacccgttggctctGagctttccttggggctttct	12	11	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:53911120G>C	uc001sdy.2	-	11	1307	c.1286C>G	c.(1285-1287)TCA>TGA	p.S429*	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Nonsense_Mutation_p.S418*|ATF7_uc010sol.1_Nonsense_Mutation_p.S397*|uc001sdx.2_RNA	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	429	Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						CGTTGGCTCTGAGCTTTCCTT	0.547													0	0	0	0.00308	0	8	20										C	53911120	G	C	53911120	4	2	6	1	0	0	0	0	0	1	0	0	1086	1294	45	1	202	1	ATF7	12	53911120	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	450960	53911120	79940775	471	1184										
GPR84	53831	broad.mit.edu	37	chr12	54756622	54756622	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actctggcatccagaatgttGagcagcaagaaggggatgta	13	7	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:54756622G>A	uc001sfu.2	-	2	1104	c.1014C>T	c.(1012-1014)CTC>CTT	p.L338L		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	338	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						CCAGAATGTTGAGCAGCAAGA	0.537													0	0	0	0.01441	0	59	168										A	54756622	G	A	54756622	2	1	6	1	0	0	0	0	0	0	0	1	6714	1277	45	1		1	GPR84	12	54756622	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	845502	54756622	79095273	472	1185										
PA2G4	5036	broad.mit.edu	37	chr12	56505295	56505295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctgcaagtcgaaaaacccaGaaaaagaaaaaaaagaaggt	8	6	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:56505295G>C	uc001sjm.2	+	12	1520	c.1101G>C	c.(1099-1101)CAG>CAC	p.Q367H	PA2G4_uc009zol.2_Intron|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	367	Necessary for nucleolar localization.|Interaction with RNA (By similarity).				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GAAAAACCCAGAAAAAGAAAA	0.393													0	0	0	0.003755	0	33	142										C	56505295	G	C	56505295	3	2	6	1	0	0	0	0	1	0	0	0	11361	933	33	1	1147	1	PA2G4	12	56505295	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1748673	56505295	77346600	473	1186										
MIP	4284	broad.mit.edu	37	chr12	56848060	56848060	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgttgagtgctaggtttcctCggacagcaggtggggtaacg	16	7	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:56848060C>G	uc001slh.2	-	1	370	c.338G>C	c.(337-339)CGA>CCA	p.R113P		NM_012064	NP_036196	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	113	Extracellular (By similarity).				response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			skin(1)	1						TAGGTTTCCTCGGACAGCAGG	0.597													0	0	0	0.003163	0	16	60										G	56848060	C	G	56848060	3	3	6	1	0	0	0	0	1	0	0	0	9591	884	31	1	469	1	MIP	12	56848060	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	342765	56848060	77003835	474	1187										
GLS2	27165	broad.mit.edu	37	chr12	56868840	56868840	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctggttaccttcttttccttGagataatagccgatggcata	8	9	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:56868840G>C	uc001slj.2	-	10	1263	c.984C>G	c.(982-984)CTC>CTG	p.L328L	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Silent_p.L63L|GLS2_uc009zot.2_Intron	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	328				LK -> HE (in Ref. 1; AAF21933).	cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCTTTTCCTTGAGATAATAGC	0.502													0	0	0	0.01441	0	56	200										C	56868840	G	C	56868840	2	2	6	1	0	0	0	0	0	0	0	1	6464	1277	45	1		1	GLS2	12	56868840	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	20780	56868840	76983055	475	1188										
DTX3	196403	broad.mit.edu	37	chr12	58001129	58001129	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaggaggcagaagagcaggaGagcacctgccccatctgtct	14	11	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:58001129G>C	uc001sow.1	+	5	820	c.483G>C	c.(481-483)GAG>GAC	p.E161D	DTX3_uc001sov.1_Missense_Mutation_p.E154D|DTX3_uc001sox.1_Missense_Mutation_p.E154D|DTX3_uc001soy.1_Missense_Mutation_p.E154D|GEFT_uc009zpy.2_5'Flank|GEFT_uc001soz.1_5'Flank	NM_178502	NP_848597	Q8N9I9	DTX3_HUMAN	deltex homolog 3	161					Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					AAGAGCAGGAGAGCACCTGCC	0.483													0	0	0	0.001984	0	6	16										C	58001129	G	C	58001129	3	2	6	1	0	0	0	0	1	0	0	0	4795	933	33	1	489	1	DTX3	12	58001129	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1132289	58001129	75850766	476	1189										
DPY19L2	283417	broad.mit.edu	37	chr12	63963010	63963010	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggttaatactcacttagttCtcacaacacaccatgcctct	5	13	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:63963010C>G	uc001srp.1	-	21	2301	c.2120G>C	c.(2119-2121)AGA>ACA	p.R707T	DPY19L2_uc010sso.1_Missense_Mutation_p.R154T	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	707					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TCACTTAGTTCTCACAACACA	0.299													0	0	0	0.01441	0	37	120										G	63963010	C	G	63963010	3	3	6	1	0	0	0	0	1	0	0	0	4741	913	32	1	164	1	DPY19L2	12	63963010	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5961881	63963010	69888885	477	1190										
KRR1	11103	broad.mit.edu	37	chr12	75900673	75900673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acagtcatgctgccttcgatCaggtccagggttgcattaac	10	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:75900673C>T	uc001sxt.2	-	3	323	c.282G>A	c.(280-282)CTG>CTA	p.L94L	KRR1_uc009zsc.2_Silent_p.L94L|KRR1_uc010stx.1_Silent_p.L94L	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	94					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						TGCCTTCGATCAGGTCCAGGG	0.373													0	0	0	0.00278	0	22	56										T	75900673	C	T	75900673	2	4	6	1	0	0	0	0	0	0	0	1	8446	813	29	1		1	KRR1	12	75900673	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	11937663	75900673	57951222	478	1191										
NAV3	89795	broad.mit.edu	37	chr12	78225383	78225383	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctttggaacttactgaaacaGagagctccatgctttcttgt	8	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:78225383G>T	uc001syp.2	+	1	315	c.142G>T	c.(142-144)GAG>TAG	p.E48*	NAV3_uc001syo.2_Nonsense_Mutation_p.E48*	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	48						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TACTGAAACAGAGAGCTCCAT	0.453										HNSCC(70;0.22)			1	0	8.16721e-17	0.010818	8.45889e-17	34	115										T	78225383	G	T	78225383	4	4	6	1	0	0	0	0	0	1	0	0	10185	943	33	3	144	3	NAV3	12	78225383	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2324710	78225383	55626512	479	1192										
C12orf50	160419	broad.mit.edu	37	chr12	88391905	88391905	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tatattttcctgaggtttcaGaggttcttgactctgggact	10	7	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:88391905G>C	uc001tam.1	-	4	364	c.196C>G	c.(196-198)CTG>GTG	p.L66V	C12orf50_uc001tan.2_Missense_Mutation_p.L120V	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	66										skin(2)|ovary(1)	3						TGAGGTTTCAGAGGTTCTTGA	0.373													0	0	0	0.014323	0	22	53										C	88391905	G	C	88391905	3	2	6	1	0	0	0	0	1	0	0	0	1695	933	33	1	1088	1	C12orf50	12	88391905	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	10166522	88391905	45459990	480	1193										
DEPDC4	120863	broad.mit.edu	37	chr12	100649888	100649888	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agtgttagtgataacaagatCttcctctttgtttagttgaa	8	5	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:100649888C>G	uc001thi.2	-	4	820	c.817G>C	c.(817-819)GAT>CAT	p.D273H	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.D219H|DEPDC4_uc009ztv.1_Missense_Mutation_p.D273H|DEPDC4_uc001thk.1_Missense_Mutation_p.D84H|DEPDC4_uc001thl.1_RNA	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	273					intracellular signal transduction						0						ATAACAAGATCTTCCTCTTTG	0.328													0	0	0	0.003954	0	26	91										G	100649888	C	G	100649888	3	3	6	1	0	0	0	0	1	0	0	0	4441	913	32	1	75	1	DEPDC4	12	100649888	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	12257983	100649888	33202007	481	1194										
UTP20	27340	broad.mit.edu	37	chr12	101711260	101711260	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttctttccacggtagcaatGagtattacccagcagatctg	8	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:101711260G>C	uc001tia.1	+	22	2713	c.2557G>C	c.(2557-2559)GAG>CAG	p.E853Q		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	853					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CGGTAGCAATGAGTATTACCC	0.473													0	0	0	0.00499	0	16	51										C	101711260	G	C	101711260	3	2	6	1	0	0	0	0	1	0	0	0	17096	1291	45	1	2643	1	UTP20	12	101711260	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1061372	101711260	32140635	482	1195										
MYBPC1	4604	broad.mit.edu	37	chr12	102036345	102036345	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gactcaagcgcatgcgcagaGaggagaagaagagcgcaggt	16	8	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:102036345G>C	uc001tii.2	+	9	841	c.739G>C	c.(739-741)GAG>CAG	p.E247Q	MYBPC1_uc001tif.1_Missense_Mutation_p.E260Q|MYBPC1_uc001tig.2_Missense_Mutation_p.E272Q|MYBPC1_uc010svq.1_Missense_Mutation_p.E234Q|MYBPC1_uc001tih.2_Missense_Mutation_p.E272Q|MYBPC1_uc001tij.2_Missense_Mutation_p.E247Q|MYBPC1_uc010svr.1_Missense_Mutation_p.E247Q|MYBPC1_uc010svs.1_Missense_Mutation_p.E247Q|MYBPC1_uc010svt.1_Missense_Mutation_p.E235Q|MYBPC1_uc010svu.1_Missense_Mutation_p.E228Q|MYBPC1_uc001tik.2_Missense_Mutation_p.E221Q	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	247					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CATGCGCAGAGAGGAGAAGAA	0.632													0	0	0	0.000602	0	4	9										C	102036345	G	C	102036345	3	2	6	1	0	0	0	0	1	0	0	0	10011	943	33	1	856	1	MYBPC1	12	102036345	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	325085	102036345	31815550	483	1196										
ANKRD13A	88455	broad.mit.edu	37	chr12	110463573	110463573	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acagtaaacaatgtgaatgtGatcaccaaaatacgcacaga	7	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:110463573G>A	uc001tpx.2	+	8	1087	c.828G>A	c.(826-828)GTG>GTA	p.V276V	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc010sxw.1_Silent_p.V276V|ANKRD13A_uc001tpy.2_5'UTR|ANKRD13A_uc001tpz.2_5'Flank	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	276											0						ATGTGAATGTGATCACCAAAA	0.398													0	0	0	0.01441	0	57	123										A	110463573	G	A	110463573	2	1	6	1	0	0	0	0	0	0	0	1	641	1277	45	1		1	ANKRD13A	12	110463573	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8427228	110463573	23388322	484	1197										
BRAP	8315	broad.mit.edu	37	chr12	112096587	112096587	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcctggcaagtatccccctCacattcatactgtactattt	4	13	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:112096587C>T	uc001tsn.3	-	9	1368	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K	BRAP_uc010syh.1_Missense_Mutation_p.E213K|BRAP_uc009zvv.2_Missense_Mutation_p.E362K	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	392					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						GTATCCCCCTCACATTCATAC	0.348													0	0	0	0.008871	0	18	73										T	112096587	C	T	112096587	3	4	6	1	0	0	0	0	1	0	0	0	1497	835	29	1	620	1	BRAP	12	112096587	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1633014	112096587	21755308	485	1198										
NOS1	4842	broad.mit.edu	37	chr12	117685219	117685219	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagagctcatccccttccctCatcttcaggatcctctcccc	4	20	5	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:117685219C>G	uc001twm.1	-	18	3443	c.2757G>C	c.(2755-2757)ATG>ATC	p.M919I		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	919	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCCCTTCCCTCATCTTCAGGA	0.547													0	0	0	0.003954	0	25	97										G	117685219	C	G	117685219	3	3	6	1	0	0	0	0	1	0	0	0	10541	826	29	1	1595	1	NOS1	12	117685219	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5588632	117685219	16166676	486	1199										
CIT	11113	broad.mit.edu	37	chr12	120166373	120166373	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgctgtaagcttcgggcattCatttcaagcatagcatgctt	9	9	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:120166373C>T	uc001txi.1	-	27	3452	c.3399G>A	c.(3397-3399)ATG>ATA	p.M1133I	CIT_uc001txh.1_Missense_Mutation_p.M667I|CIT_uc001txj.1_Missense_Mutation_p.M1175I	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1133	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTCGGGCATTCATTTCAAGCA	0.463													0	0	0	0.01441	0	84	280										T	120166373	C	T	120166373	3	4	6	1	0	0	0	0	1	0	0	0	3438	826	29	1	2768	1	CIT	12	120166373	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2481154	120166373	13685522	487	1200										
KDM2B	84678	broad.mit.edu	37	chr12	121882022	121882022	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cggttcatcttctgctccttGagcagggagccgggcaggtt	14	11	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:121882022G>C	uc001uat.2	-	16	2348	c.2244C>G	c.(2242-2244)CTC>CTG	p.L748L	KDM2B_uc001uaq.2_Silent_p.L188L|KDM2B_uc010szy.1_Silent_p.L188L|KDM2B_uc001uar.2_Silent_p.L339L|KDM2B_uc001uas.2_Silent_p.L717L|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_5'UTR|KDM2B_uc010szx.1_5'UTR|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	748					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						TCTGCTCCTTGAGCAGGGAGC	0.572											OREG0022201	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	38	90										C	121882022	G	C	121882022	2	2	6	1	0	0	0	0	0	0	0	1	8125	1277	45	1		1	KDM2B	12	121882022	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1715649	121882022	11969873	488	1201										
SETD8	387893	broad.mit.edu	37	chr12	123875261	123875261	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcgtttcccccttcaggaaGagaactcagttacacatcac	7	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:123875261G>A	uc001uew.2	+	3	259	c.217G>A	c.(217-219)GAG>AAG	p.E73K	SETD8_uc001uex.2_Missense_Mutation_p.E8K	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	114					cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		CCTTCAGGAAGAGAACTCAGT	0.453													0	0	0	0.00333	0	24	90										A	123875261	G	A	123875261	3	1	6	1	0	0	0	0	1	0	0	0	14137	943	33	1	227	1	SETD8	12	123875261	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1993239	123875261	9976634	489	1202										
PIWIL1	9271	broad.mit.edu	37	chr12	130830392	130830392	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttggtgtgaatacaaggcaGaacctagaccatgttaaaga	10	7	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:130830392G>A	uc001uik.2	+	4	375	c.285G>A	c.(283-285)CAG>CAA	p.Q95Q	PIWIL1_uc001uij.1_Silent_p.Q95Q	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	95					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATACAAGGCAGAACCTAGACC	0.393													0	0	0	0.007413	0	19	84										A	130830392	G	A	130830392	2	1	6	1	0	0	0	0	0	0	0	1	11957	933	33	1		1	PIWIL1	12	130830392	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6955131	130830392	3021503	490	1203										
GPR133	283383	broad.mit.edu	37	chr12	131498798	131498798	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgttcgccaccagccacctGatttccctggaggtgtcccc	9	17	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr12:131498798G>A	uc001uit.3	+	13	1945	c.1386G>A	c.(1384-1386)CTG>CTA	p.L462L	GPR133_uc010tbm.1_Silent_p.L494L	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	462	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCAGCCACCTGATTTCCCTGG	0.582													0	0	0	0.00308	0	8	102										A	131498798	G	A	131498798	2	1	6	1	0	0	0	0	0	0	0	1	6643	1277	45	1		1	GPR133	12	131498798	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	668406	131498798	2353097	491	1204										
ZMYM2	7750	broad.mit.edu	37	chr13	20567555	20567555	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcagaagggaagtgtaagtGagacaattgtcattgatgat	12	4	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:20567555G>A	uc001umr.2	+	4	641	c.343G>A	c.(343-345)GAG>AAG	p.E115K	ZMYM2_uc001umq.2_Missense_Mutation_p.E115K|ZMYM2_uc001ums.2_Missense_Mutation_p.E115K|ZMYM2_uc001umt.2_Missense_Mutation_p.E115K|ZMYM2_uc009zzn.1_Missense_Mutation_p.E137K	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		AAGTGTAAGTGAGACAATTGT	0.353													0	0	0	0.001855	0	13	33										A	20567555	G	A	20567555	3	1	6	1	0	0	0	0	1	0	0	0	17697	1291	45	1	345	1	ZMYM2	13	20567555	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		20567555	94602323	492	1205										
ZMYM2	7750	broad.mit.edu	37	chr13	20567608	20567608	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaacaaatcaagggcaagaGaaaaattcctccaattttat	6	7	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:20567608G>C	uc001umr.2	+	4	694	c.396G>C	c.(394-396)GAG>GAC	p.E132D	ZMYM2_uc001umq.2_Missense_Mutation_p.E132D|ZMYM2_uc001ums.2_Missense_Mutation_p.E132D|ZMYM2_uc001umt.2_Missense_Mutation_p.E132D|ZMYM2_uc009zzn.1_Missense_Mutation_p.E154D	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		AAGGGCAAGAGAAAAATTCCT	0.383													0	0	0	0.004007	0	17	65										C	20567608	G	C	20567608	3	2	6	1	0	0	0	0	1	0	0	0	17697	933	33	1	398	1	ZMYM2	13	20567608	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	53	20567608	94602270	493	1206										
MRP63	78988	broad.mit.edu	37	chr13	21751269	21751269	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcgcaggagggaggccttcGaggccataaaggcggccgcc	17	12	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:21751269G>C	uc001unw.2	+	2	704	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	SKA3_uc001unt.2_5'Flank|SKA3_uc001unv.2_5'Flank|SKA3_uc001unu.2_5'Flank	NM_024026	NP_076931	Q9BQC6	RT63_HUMAN	mitochondrial ribosomal protein 63	72											0		all_cancers(29;2.76e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.43e-05)|Epithelial(112;0.000285)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|Lung(94;0.0932)		GGAGGCCTTCGAGGCCATAAA	0.612													0	0	0	0.013537	0	12	41										C	21751269	G	C	21751269	3	2	6	1	0	0	0	0	1	0	0	0	9773	1059	37	1	216	1	MRP63	13	21751269	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1183661	21751269	93418609	494	1207										
NBEA	26960	broad.mit.edu	37	chr13	36229746	36229746	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcagattgtatttggccattGggatgtggtcacttgcttgg	13	6	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:36229746G>A	uc001uvb.2	+	54	8365	c.8159G>A	c.(8158-8160)TGG>TAG	p.W2720*	NBEA_uc010abi.2_Nonsense_Mutation_p.W1376*|NBEA_uc010tef.1_Nonsense_Mutation_p.W513*|NBEA_uc001uvd.2_Nonsense_Mutation_p.W298*	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2720	WD 2.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TTTGGCCATTGGGATGTGGTC	0.458													0	0	0	0.01441	0	61	214										A	36229746	G	A	36229746	4	1	6	1	0	0	0	0	0	1	0	0	10187	1357	47	2	8373	2	NBEA	13	36229746	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14478477	36229746	78940132	495	1208										
ELF1	1997	broad.mit.edu	37	chr13	41515451	41515451	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttttggcatttctttaaactGatacaccaagcgctgacctt	6	10	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:41515451G>A	uc001uxs.2	-	8	1235	c.862C>T	c.(862-864)CAG>TAG	p.Q288*	ELF1_uc010tfc.1_Nonsense_Mutation_p.Q264*|ELF1_uc010acd.2_Nonsense_Mutation_p.Q181*	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	288	ETS.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		TCTTTAAACTGATACACCAAG	0.368													0	0	0	0.01441	0	58	185										A	41515451	G	A	41515451	4	1	6	1	0	0	0	0	0	1	0	0	5053	1299	45	1	1005	1	ELF1	13	41515451	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5285705	41515451	73654427	496	1209										
KBTBD6	89890	broad.mit.edu	37	chr13	41705016	41705016	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggaatattattcatttgcctCcattctgccctaactgggtt	7	10	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:41705016C>G	uc001uxu.1	-	1	1921	c.1632G>C	c.(1630-1632)TGG>TGC	p.W544C	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.W478C|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	544	Kelch 4.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		TCATTTGCCTCCATTCTGCCC	0.448													0	0	0	0.01441	0	52	173										G	41705016	C	G	41705016	3	3	6	1	0	0	0	0	1	0	0	0	7997	856	30	1	396	1	KBTBD6	13	41705016	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	189565	41705016	73464862	497	1210										
KBTBD6	89890	broad.mit.edu	37	chr13	41705099	41705099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcattgaagacgcaggcttCctgaaagtcattgcgcttca	9	11	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:41705099C>T	uc001uxu.1	-	1	1838	c.1549G>A	c.(1549-1551)GAA>AAA	p.E517K	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.E451K|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	517	Kelch 3.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ACGCAGGCTTCCTGAAAGTCA	0.433													0	0	0	0.007413	0	20	109										T	41705099	C	T	41705099	3	4	6	1	0	0	0	0	1	0	0	0	7997	864	30	1	479	1	KBTBD6	13	41705099	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	83	41705099	73464779	498	1211										
KBTBD6	89890	broad.mit.edu	37	chr13	41706332	41706332	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cacgctggcctgctggctctCgtacatgccacctgtgaaca	10	15	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:41706332C>G	uc001uxu.1	-	1	605	c.316G>C	c.(316-318)GAG>CAG	p.E106Q	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Intron|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	106	BTB.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		TGCTGGCTCTCGTACATGCCA	0.622													0	0	0	0.004007	0	17	59										G	41706332	C	G	41706332	3	3	6	1	0	0	0	0	1	0	0	0	7997	893	31	1	1712	1	KBTBD6	13	41706332	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1233	41706332	73463546	499	1212										
NAA16	79612	broad.mit.edu	37	chr13	41943355	41943355	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaaaatcaaaagaaaaaaaGagatgaagaagaagaagaag	10	1	1	7			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:41943355G>C	uc001uyf.2	+	15	2207	c.1883G>C	c.(1882-1884)AGA>ACA	p.R628T	NAA16_uc010tfg.1_RNA	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	628					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						aagaaaaaaagagatgaagaa	0.224													0	0	0	0.013537	0	13	69										C	41943355	G	C	41943355	3	2	6	1	0	0	0	0	1	0	0	0	10119	942	33	1	1974	1	NAA16	13	41943355	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	237023	41943355	73226523	500	1213										
TNFSF11	8600	broad.mit.edu	37	chr13	43180957	43180957	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attttttaagttacggtctgGagaggaaatcagcatcgagg	12	5	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:43180957G>C	uc001uyu.2	+	5	1006	c.857G>C	c.(856-858)GGA>GCA	p.G286A	TNFSF11_uc001uyt.2_Missense_Mutation_p.G213A	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	286	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTACGGTCTGGAGAGGAAATC	0.433													0	0	0	0.004289	0	36	135										C	43180957	G	C	43180957	3	2	6	1	0	0	0	0	1	0	0	0	16299	1174	41	1	875	1	TNFSF11	13	43180957	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1237602	43180957	71988921	501	1214										
KPNA3	3839	broad.mit.edu	37	chr13	50276524	50276524	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attttaatatctacttacatCatcaccagagaaatactgat	3	8	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:50276524C>T	uc001vdj.2	-	16	1880	c.1465G>A	c.(1465-1467)GAT>AAT	p.D489N		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	489					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		CTACTTACATCATCACCAGAG	0.274													0	0	0	0.008291	0	9	42										T	50276524	C	T	50276524	3	4	6	1	0	0	0	0	1	0	0	0	8431	826	29	1	108	1	KPNA3	13	50276524	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7095567	50276524	64893354	502	1215										
KPNA3	3839	broad.mit.edu	37	chr13	50299570	50299570	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actagactgcacaacagcttGagtctgtgcagaagttcctg	10	10	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:50299570G>A	uc001vdj.2	-	7	866	c.451C>T	c.(451-453)CAA>TAA	p.Q151*		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	151	ARM 3.|NLS binding site (major) (By similarity).				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		ACAACAGCTTGAGTCTGTGCA	0.338													0	0	0	0.004007	0	14	44										A	50299570	G	A	50299570	4	1	6	1	0	0	0	0	0	1	0	0	8431	1299	45	1	1158	1	KPNA3	13	50299570	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	23046	50299570	64870308	503	1216										
KPNA3	3839	broad.mit.edu	37	chr13	50299581	50299581	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caacagcttgagtctgtgcaGaagttcctgatgctatgtta	10	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:50299581G>A	uc001vdj.2	-	7	855	c.440C>T	c.(439-441)TCT>TTT	p.S147F		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	147	ARM 2.|NLS binding site (major) (By similarity).				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		AGTCTGTGCAGAAGTTCCTGA	0.348													0	0	0	0.00499	0	15	49										A	50299581	G	A	50299581	3	1	6	1	0	0	0	0	1	0	0	0	8431	942	33	1	1169	1	KPNA3	13	50299581	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11	50299581	64870297	504	1217										
KLF5	688	broad.mit.edu	37	chr13	73636362	73636362	+	Frame_Shift_Del	DEL	A	A	-													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggtgaacaatattttcatcAaacaagaacttcctacacca							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:73636362delA	uc001vje.2	+	2	949	c.625delA	c.(625-627)AAAfs	p.K209fs	KLF5_uc001vjd.2_Frame_Shift_Del_p.K118fs	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	209					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TATTTTCATCAAACAAGAACT	0.532																		22	81	---	---								-	73636362	A	-	73636362	7	5	6	1	0	1	0	1	0	0	0	0	8349	131	5	0	631	0	KLF5	13	73636362	Frame_Shift_Del	DEL	A	TCGA-BT-A0YX-01A-11D-A10S-08	23336781	73636362	41533516	505	1218										
GPC5	2262	broad.mit.edu	37	chr13	92560198	92560198	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttcccttgctagttatactCagcgtgtggttggaaatgga	11	7	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:92560198C>T	uc010tif.1	+	6	1654	c.1288C>T	c.(1288-1290)CAG>TAG	p.Q430*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	430						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TAGTTATACTCAGCGTGTGGT	0.383													0	0	0	0.00278	0	20	74										T	92560198	C	T	92560198	4	4	6	1	0	0	0	0	0	1	0	0	6601	827	29	1	1310	1	GPC5	13	92560198	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	18923836	92560198	22609680	506	1219										
TPP2	7174	broad.mit.edu	37	chr13	103298650	103298650	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttcctcattacagcccagtGagtgcaaaaacaaaaccttt	5	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:103298650G>A	uc001vpi.3	+	20	2503	c.2400G>A	c.(2398-2400)GTG>GTA	p.V800V		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	800					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACAGCCCAGTGAGTGCAAAAA	0.338													0	0	0	0.010729	0	11	41										A	103298650	G	A	103298650	2	1	6	1	0	0	0	0	0	0	0	1	16409	1277	45	1		1	TPP2	13	103298650	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	10738452	103298650	11871228	507	1220										
SLC10A2	6555	broad.mit.edu	37	chr13	103701788	103701788	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccccgtttcaaaagcaaccGttcggcacctaaagaagatg	8	12	1	2	rs145541774		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:103701788G>A	uc001vpy.3	-	5	1367	c.770C>T	c.(769-771)ACG>ATG	p.T257M		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	257	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAAAGCAACCGTTCGGCACCT	0.408													0	0	0	0.006122	0	18	55										A	103701788	G	A	103701788	3	1	6	1	0	0	0	0	1	0	0	0	14374	1145	40	2	284	2	SLC10A2	13	103701788	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	403138	103701788	11468090	508	1221										
FAM155A	728215	broad.mit.edu	37	chr13	108518440	108518440	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gccctgggggtaacaagtctCcaggcgccacacgggcttgg	15	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr13:108518440C>T	uc001vql.2	-	1	1021	c.505G>A	c.(505-507)GAG>AAG	p.E169K		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	169						integral to membrane	binding			skin(1)	1						TAACAAGTCTCCAGGCGCCAC	0.697													0	0	0	0.004007	0	16	66										T	108518440	C	T	108518440	3	4	6	1	0	0	0	0	1	0	0	0	5465	864	30	1	883	1	FAM155A	13	108518440	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4816652	108518440	6651438	509	1222										
TEP1	7011	broad.mit.edu	37	chr14	20841487	20841487	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcctcagaggcggtcagcatGaggcctgaggtttctgaaac	13	10	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:20841487G>A	uc001vxe.2	-	47	6796	c.6756C>T	c.(6754-6756)CTC>CTT	p.L2252L	TEP1_uc010ahj.1_5'Flank|TEP1_uc010ahk.2_Silent_p.L1595L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L2144L|TEP1_uc010tlh.1_Silent_p.L590L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2252	WD 15.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CGGTCAGCATGAGGCCTGAGG	0.587													0	0	0	0.004878	0	38	113										A	20841487	G	A	20841487	2	1	6	1	0	0	0	0	0	0	0	1	15756	1277	45	1		1	TEP1	14	20841487	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		20841487	86508053	510	1223										
RNASE10	338879	broad.mit.edu	37	chr14	20978929	20978929	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taacaagatgctcagagcctCagctctctttcagagcaaca	7	12	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:20978929C>G	uc010tlj.1	+	1	299	c.299C>G	c.(298-300)TCA>TGA	p.S100*	RNASE10_uc001vxp.2_Nonsense_Mutation_p.S128*	NM_001012975	NP_001012993	Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	100						extracellular region	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		CTCAGAGCCTCAGCTCTCTTT	0.493													0	0	0	0.008291	0	11	35										G	20978929	C	G	20978929	4	3	6	1	0	0	0	0	0	1	0	0	13400	838	29	1	301	1	RNASE10	14	20978929	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	137442	20978929	86370611	511	1224										
CHD8	57680	broad.mit.edu	37	chr14	21863460	21863460	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgacctagaagtttaccttCatctccatcaatcactgaga	5	11	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:21863460C>T	uc001was.1	-	29	4436	c.4342G>A	c.(4342-4344)GAA>AAA	p.E1448K	CHD8_uc001war.1_Missense_Mutation_p.E1344K	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1727					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGTTTACCTTCATCTCCATCA	0.468													0	0	0	0.001984	0	7	24										T	21863460	C	T	21863460	3	4	6	1	0	0	0	0	1	0	0	0	3331	835	29	1	2606	1	CHD8	14	21863460	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	884531	21863460	85486080	512	1225										
CDH24	64403	broad.mit.edu	37	chr14	23524387	23524387	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggggctccaggggccggttgGaggctcggtccacggcttgg	20	11	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:23524387G>A	uc001wil.2	-	3	637	c.377C>T	c.(376-378)TCC>TTC	p.S126F	CDH24_uc010akf.2_Missense_Mutation_p.S126F|CDH24_uc001win.3_Missense_Mutation_p.S126F	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	126	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		GGGCCGGTTGGAGGCTCGGTC	0.552											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	20	131										A	23524387	G	A	23524387	3	1	6	1	0	0	0	0	1	0	0	0	3109	1174	41	1	2126	1	CDH24	14	23524387	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1660927	23524387	83825153	513	1226										
HECTD1	25831	broad.mit.edu	37	chr14	31574848	31574848	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgtaaaaccatatattcttGaggaagggcaaaactggaaa	9	6	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:31574848G>C	uc001wrc.1	-	39	7742	c.7253C>G	c.(7252-7254)TCA>TGA	p.S2418*	HECTD1_uc001wra.1_Nonsense_Mutation_p.S544*|HECTD1_uc001wrb.1_Nonsense_Mutation_p.S544*	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2418	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ATATATTCTTGAGGAAGGGCA	0.328													0	0	0	0.003271	0	35	83										C	31574848	G	C	31574848	4	2	6	1	0	0	0	0	0	1	0	0	7039	1294	45	1	599	1	HECTD1	14	31574848	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8050461	31574848	75774692	514	1227										
PSMA6	5687	broad.mit.edu	37	chr14	35786501	35786501	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcaccttgttgctctagcaGagagagactaaacattgtcg	9	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:35786501G>C	uc001wtd.2	+	7	839	c.730G>C	c.(730-732)GAG>CAG	p.E244Q	KIAA0391_uc001wta.2_RNA|PSMA6_uc010tpt.1_Missense_Mutation_p.E165Q|PSMA6_uc010tpu.1_Missense_Mutation_p.E165Q	NM_002791	NP_002782	P60900	PSA6_HUMAN	proteasome alpha 6 subunit	244					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nuclear matrix|polysome|proteasome core complex, alpha-subunit complex|sarcomere	NF-kappaB binding|purine ribonucleoside triphosphate binding|RNA binding|threonine-type endopeptidase activity				0	Breast(36;0.0519)|Hepatocellular(127;0.158)		Lung(238;3.81e-05)|LUAD - Lung adenocarcinoma(48;5.59e-05)|Epithelial(34;0.00342)|all cancers(34;0.00973)	GBM - Glioblastoma multiforme(112;0.0234)		TGCTCTAGCAGAGAGAGACTA	0.383													0	0	0	0.012213	0	30	168										C	35786501	G	C	35786501	3	2	6	1	0	0	0	0	1	0	0	0	12671	943	33	1	756	1	PSMA6	14	35786501	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4211653	35786501	71563039	515	1228										
CTAGE5	4253	broad.mit.edu	37	chr14	39762517	39762517	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtccaattctgaacttgagGatgaaatactctgtctagaa	9	7	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:39762517G>A	uc001wvg.3	+	6	763	c.427G>A	c.(427-429)GAT>AAT	p.D143N	CTAGE5_uc010tqe.1_Missense_Mutation_p.D105N|CTAGE5_uc001wuz.3_Missense_Mutation_p.D131N|CTAGE5_uc001wuy.3_Missense_Mutation_p.D63N|CTAGE5_uc001wvb.3_Missense_Mutation_p.D114N|CTAGE5_uc001wvc.3_Missense_Mutation_p.D88N|CTAGE5_uc001wva.3_Missense_Mutation_p.D114N|CTAGE5_uc001wve.1_Missense_Mutation_p.D119N|CTAGE5_uc001wvh.3_Missense_Mutation_p.D143N|CTAGE5_uc001wvf.3_Missense_Mutation_p.D68N|CTAGE5_uc001wvi.3_Missense_Mutation_p.D148N|CTAGE5_uc010amz.2_5'UTR|CTAGE5_uc001wvj.3_Missense_Mutation_p.D114N	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	143	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TGAACTTGAGGATGAAATACT	0.323													0	0	0	0.00308	0	6	66										A	39762517	G	A	39762517	3	1	6	1	0	0	0	0	1	0	0	0	3994	1174	41	1	480	1	CTAGE5	14	39762517	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3976016	39762517	67587023	516	1229										
FANCM	57697	broad.mit.edu	37	chr14	45658401	45658401	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttctactccaagagttaatCcattagcaaagcagagcaaa	7	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:45658401C>G	uc001wwd.3	+	20	5275	c.5176C>G	c.(5176-5178)CCA>GCA	p.P1726A	FANCM_uc010anf.2_Missense_Mutation_p.P1700A|FANCM_uc001wwe.3_Missense_Mutation_p.P1262A|FANCM_uc010ang.2_Missense_Mutation_p.P940A	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1726					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AAGAGTTAATCCATTAGCAAA	0.408								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	72	222										G	45658401	C	G	45658401	3	3	6	1	0	0	0	0	1	0	0	0	5671	855	30	1	5254	1	FANCM	14	45658401	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5895884	45658401	61691139	517	1230										
NIN	51199	broad.mit.edu	37	chr14	51196370	51196370	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcaccatcggacaggcttgCtgctggagcagctgcaaatc	13	12	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:51196370C>T	uc001wym.2	-	29	6140	c.5949G>A	c.(5947-5949)CAG>CAA	p.Q1983Q	NIN_uc001wyi.2_Silent_p.Q1983Q|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.Q1270Q|NIN_uc010tqp.1_Silent_p.Q1989Q|NIN_uc001wyo.2_Silent_p.Q1983Q|NIN_uc001wyn.2_RNA	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1983	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GACAGGCTTGCTGCTGGAGCA	0.582			T	PDGFRB	MPD								0	0	0	0.004482	0	5	19										T	51196370	C	T	51196370	2	4	6	1	0	0	0	0	0	0	0	1	10417	796	28	2		2	NIN	14	51196370	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5537969	51196370	56153170	518	1231										
NIN	51199	broad.mit.edu	37	chr14	51204915	51204915	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcacactctctctttaagctCaatttttcttgctctgtggg	6	11	6	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:51204915C>T	uc001wym.2	-	27	5909	c.5718G>A	c.(5716-5718)TTG>TTA	p.L1906L	NIN_uc001wyi.2_Silent_p.L1906L|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.L1193L|NIN_uc010tqp.1_Silent_p.L1912L|NIN_uc001wyo.2_Silent_p.L1906L|NIN_uc001wyn.2_RNA	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1906					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TCTTTAAGCTCAATTTTTCTT	0.413			T	PDGFRB	MPD								0	0	0	0.010771	0	46	146										T	51204915	C	T	51204915	2	4	6	1	0	0	0	0	0	0	0	1	10417	825	29	1		1	NIN	14	51204915	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	8545	51204915	56144625	519	1232										
MUDENG	55745	broad.mit.edu	37	chr14	57741516	57741516	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caaaggaaaaccacaagtttCtatttctatcactgaaaagg	6	8	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:57741516C>G	uc001xcv.2	+	2	1056	c.629C>G	c.(628-630)TCT>TGT	p.S210C	MUDENG_uc001xcu.3_Missense_Mutation_p.S210C|MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_Missense_Mutation_p.S107C	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	210	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						CCACAAGTTTCTATTTCTATC	0.378													0	0	0	0.014323	0	22	101										G	57741516	C	G	57741516	3	3	6	1	0	0	0	0	1	0	0	0	9983	913	32	1	635	1	MUDENG	14	57741516	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6536601	57741516	49608024	520	1233										
ARID4A	5926	broad.mit.edu	37	chr14	58831340	58831340	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttcttctgctacagaagatGaaattgaccaatgtgtgaaa	8	6	2	5			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:58831340G>A	uc001xdp.2	+	20	2787	c.2533G>A	c.(2533-2535)GAA>AAA	p.E845K	ARID4A_uc001xdo.2_Missense_Mutation_p.E845K|ARID4A_uc001xdq.2_Missense_Mutation_p.E845K|ARID4A_uc010apg.1_Missense_Mutation_p.E523K	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	845					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TACAGAAGATGAAATTGACCA	0.343													0	0	0	0.00308	0	8	50										A	58831340	G	A	58831340	3	1	6	1	0	0	0	0	1	0	0	0	919	1291	45	1	2607	1	ARID4A	14	58831340	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1089824	58831340	48518200	521	1234										
C14orf39	317761	broad.mit.edu	37	chr14	60923747	60923747	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agacgttcgtggaaaattctCagctctctcttctacttcat	6	11	5	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:60923747C>T	uc001xez.3	-	15	1356	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	C14orf39_uc010apo.2_Missense_Mutation_p.E127K	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	416										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		GGAAAATTCTCAGCTCTCTCT	0.353													0	0	0	0.01441	0	47	158										T	60923747	C	T	60923747	3	4	6	1	0	0	0	0	1	0	0	0	1772	835	29	1	533	1	C14orf39	14	60923747	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2092407	60923747	46425793	522	1235										
PSEN1	5663	broad.mit.edu	37	chr14	73614734	73614734	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atacagttgctccaatgacaGagttacctgcaccgttgtcc	8	12	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:73614734G>A	uc001xnr.2	+	3	291	c.7G>A	c.(7-9)GAG>AAG	p.E3K	PSEN1_uc001xnv.2_Missense_Mutation_p.E3K|PSEN1_uc010ark.2_Missense_Mutation_p.E3K|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA|PSEN1_uc001xnq.3_Missense_Mutation_p.E3K	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	3	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		TCCAATGACAGAGTTACCTGC	0.428													0	0	0	0.003163	0	11	38										A	73614734	G	A	73614734	3	1	6	1	0	0	0	0	1	0	0	0	12650	943	33	1	9	1	PSEN1	14	73614734	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	12690987	73614734	33734806	523	1236										
ACOT6	641372	broad.mit.edu	37	chr14	74086448	74086448	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atggaggtgagccaaaggctCactcaaaggcacaggtagat	13	8	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:74086448C>T	uc001xop.2	+	2	860	c.529C>T	c.(529-531)CAC>TAC	p.H177Y		NM_001037162	NP_001032239	Q3I5F7	ACOT6_HUMAN	acyl-CoA thioesterase 6	177						cytosol	carboxylesterase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		GCCAAAGGCTCACTCAAAGGC	0.423													0	0	0	0.013537	0	13	71										T	74086448	C	T	74086448	3	4	6	1	0	0	0	0	1	0	0	0	154	826	29	1	535	1	ACOT6	14	74086448	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	471714	74086448	33263092	524	1237										
PNMA1	9240	broad.mit.edu	37	chr14	74179622	74179622	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgggcatccctagagctctCaacgctcccaaacacctgct	7	17	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:74179622C>G	uc001xor.1	-	1	1507	c.721G>C	c.(721-723)GAG>CAG	p.E241Q		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	241					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		ctagagctctcaacgctccca	0													0	0	0	0.006999	0	35	132										G	74179622	C	G	74179622	3	3	6	1	0	0	0	0	1	0	0	0	12153	835	29	1	344	1	PNMA1	14	74179622	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	93174	74179622	33169918	525	1238										
PNMA1	9240	broad.mit.edu	37	chr14	74180243	74180243	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctggagggtctcttcgatttCagcctcatcacagttcactg	9	12	5	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:74180243C>T	uc001xor.1	-	1	886	c.100G>A	c.(100-102)GAA>AAA	p.E34K		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	34					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		tcttcgatttcagcctcatca	0													0	0	0	0.01441	0	57	171										T	74180243	C	T	74180243	3	4	6	1	0	0	0	0	1	0	0	0	12153	835	29	1	965	1	PNMA1	14	74180243	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	621	74180243	33169297	526	1239										
C14orf115	55237	broad.mit.edu	37	chr14	74824670	74824670	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgctccgcactggcggtgtCaagccctggaatggtcttaa	13	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:74824670C>G	uc001xpw.3	+	2	1375	c.1184C>G	c.(1183-1185)TCA>TGA	p.S395*		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	395					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		CTGGCGGTGTCAAGCCCTGGA	0.607													0	0	0	0.004482	0	9	58										G	74824670	C	G	74824670	4	3	6	1	0	0	0	0	0	1	0	0	1740	838	29	1	1186	1	C14orf115	14	74824670	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	644427	74824670	32524870	527	1240										
TTLL5	23093	broad.mit.edu	37	chr14	76249706	76249706	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aattttactgaacacagtctCtgccagtgcttctccctgcc	6	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:76249706C>T	uc001xrx.2	+	26	3024	c.2819C>T	c.(2818-2820)TCT>TTT	p.S940F	TTLL5_uc010ask.1_Missense_Mutation_p.S954F|TTLL5_uc001xrz.2_Missense_Mutation_p.S515F|TTLL5_uc001xsa.2_Missense_Mutation_p.S13F|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	940					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		AACACAGTCTCTGCCAGTGCT	0.537													0	0	0	0.00333	0	25	90										T	76249706	C	T	76249706	3	4	6	1	0	0	0	0	1	0	0	0	16727	913	32	1	2917	1	TTLL5	14	76249706	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1425036	76249706	31099834	528	1241										
TTLL5	23093	broad.mit.edu	37	chr14	76249833	76249833	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttccaaagtgctgcacacatCtatagccagaaactgtctcg	7	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:76249833C>T	uc001xrx.2	+	26	3151	c.2946C>T	c.(2944-2946)ATC>ATT	p.I982I	TTLL5_uc010ask.1_Silent_p.I996I|TTLL5_uc001xrz.2_Silent_p.I557I|TTLL5_uc001xsa.2_Silent_p.I55I|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	982					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		CTGCACACATCTATAGCCAGA	0.532													0	0	0	0.012319	0	20	109										T	76249833	C	T	76249833	2	4	6	1	0	0	0	0	0	0	0	1	16727	903	32	1		1	TTLL5	14	76249833	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	127	76249833	31099707	529	1242										
C14orf4	64207	broad.mit.edu	37	chr14	77492255	77492255	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agagtatctgccaccgacatGagagcggccataggggacgg	15	10	1	2	rs142866521		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:77492255G>C	uc001xsy.2	-	1	2780	c.1881C>G	c.(1879-1881)CTC>CTG	p.L627L		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	627						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		CCACCGACATGAGAGCGGCCA	0.582													0	0	0	0.001168	0	6	20										C	77492255	G	C	77492255	2	2	6	1	0	0	0	0	0	0	0	1	1773	1277	45	1		1	C14orf4	14	77492255	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1242422	77492255	29857285	530	1243										
SEL1L	6400	broad.mit.edu	37	chr14	81950592	81950592	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttaatgcccagtcctttctCatgcatatatcccagattaa	4	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:81950592C>G	uc010tvv.1	-	19	2140	c.2023G>C	c.(2023-2025)GAG>CAG	p.E675Q		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	675	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 11.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		AGTCCTTTCTCATGCATATAT	0.393													0	0	0	0.01441	0	147	551										G	81950592	C	G	81950592	3	3	6	1	0	0	0	0	1	0	0	0	14010	835	29	1	373	1	SEL1L	14	81950592	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4458337	81950592	25398948	531	1244										
ATG2B	55102	broad.mit.edu	37	chr14	96807895	96807895	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acttcattctgtttcaacgtGagactcaactccaacctacc	4	14	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:96807895G>A	uc001yfi.2	-	6	1253	c.888C>T	c.(886-888)CTC>CTT	p.L296L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	296										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GTTTCAACGTGAGACTCAACT	0.393													0	0	0	0.008361	0	25	94										A	96807895	G	A	96807895	2	1	6	1	0	0	0	0	0	0	0	1	1094	1277	45	1		1	ATG2B	14	96807895	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14857303	96807895	10541645	532	1245										
AK7	122481	broad.mit.edu	37	chr14	96912857	96912857	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacctgtgggtctgcagagtGatacaaaacgtcatagatca	10	8	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:96912857G>C	uc001yfn.2	+	8	827	c.783G>C	c.(781-783)GTG>GTC	p.V261V		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	261	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TCTGCAGAGTGATACAAAACG	0.473													0	0	0	0.007291	0	25	59										C	96912857	G	C	96912857	2	2	6	1	0	0	0	0	0	0	0	1	444	1277	45	1		1	AK7	14	96912857	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	104962	96912857	10436683	533	1246										
BAG5	9529	broad.mit.edu	37	chr14	104026370	104026370	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagaacttctccctggatctCagacaagtttccaaggacgt	8	11	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:104026370C>A	uc001yni.1	-	2	1366	c.1132G>T	c.(1132-1134)GAG>TAG	p.E378*	KLC1_uc010tyd.1_5'Flank|BAG5_uc001ynh.1_Nonsense_Mutation_p.E419*|BAG5_uc001ynj.1_Nonsense_Mutation_p.E378*|C14orf153_uc001ynl.3_5'Flank|C14orf153_uc010tyc.1_5'Flank	NM_004873	NP_004864	Q9UL15	BAG5_HUMAN	BCL2-associated athanogene 5 isoform b	378	BAG 5.				apoptosis|negative regulation of protein refolding|negative regulation of ubiquitin-protein ligase activity|neuron death|protein folding|regulation of inclusion body assembly	inclusion body|perinuclear region of cytoplasm	chaperone binding|ubiquitin protein ligase binding			ovary(2)	2		Melanoma(154;0.155)	Epithelial(46;0.144)			CCCTGGATCTCAGACAAGTTT	0.483													1	0	1.34996e-11	0.009718	1.38734e-11	39	121										A	104026370	C	A	104026370	4	1	6	1	0	0	0	0	0	1	0	0	1290	835	29	3	215	3	BAG5	14	104026370	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7113513	104026370	3323170	534	1247										
BAG5	9529	broad.mit.edu	37	chr14	104026577	104026577	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccaattaaaccctgcaattCtgttttggagctcaggtaca	7	10	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:104026577C>T	uc001yni.1	-	2	1159	c.925G>A	c.(925-927)GAA>AAA	p.E309K	KLC1_uc010tyd.1_5'Flank|BAG5_uc001ynh.1_Missense_Mutation_p.E350K|BAG5_uc001ynj.1_Missense_Mutation_p.E309K|C14orf153_uc001ynl.3_5'Flank|C14orf153_uc010tyc.1_5'Flank	NM_004873	NP_004864	Q9UL15	BAG5_HUMAN	BCL2-associated athanogene 5 isoform b	309	BAG 4.				apoptosis|negative regulation of protein refolding|negative regulation of ubiquitin-protein ligase activity|neuron death|protein folding|regulation of inclusion body assembly	inclusion body|perinuclear region of cytoplasm	chaperone binding|ubiquitin protein ligase binding			ovary(2)	2		Melanoma(154;0.155)	Epithelial(46;0.144)			CCCTGCAATTCTGTTTTGGAG	0.408													0	0	0	0.008361	0	31	102										T	104026577	C	T	104026577	3	4	6	1	0	0	0	0	1	0	0	0	1290	922	32	1	422	1	BAG5	14	104026577	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	207	104026577	3322963	535	1248										
KLC1	3831	broad.mit.edu	37	chr14	104037964	104037964	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atttactttgttaaaggtctCaagattctgccctccaagaa	6	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:104037964C>G	uc010tyd.1	+	2	168	c.128C>G	c.(127-129)TCA>TGA	p.S43*	C14orf153_uc001ynl.3_RNA|C14orf153_uc010tyc.1_Nonsense_Mutation_p.S56*	NM_005552	NP_005543	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 1	Error:Variant_position_missing_in_Q07866_after_alignment					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				TTAAAGGTCTCAAGATTCTGC	0.299													0	0	0	0.003954	0	25	107										G	104037964	C	G	104037964	4	3	6	1	0	0	0	0	0	1	0	0	8333	838	29	1		1	KLC1	14	104037964	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	11387	104037964	3311576	536	1249										
INF2	64423	broad.mit.edu	37	chr14	105169764	105169764	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gccccgaggacctgcgcgcgCgcacccagctgcggaacgag	15	17	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:105169764C>T	uc001ypb.2	+	4	783	c.640C>T	c.(640-642)CGC>TGC	p.R214C	INF2_uc010tyi.1_Missense_Mutation_p.R214C|INF2_uc001ypc.2_Missense_Mutation_p.R214C|INF2_uc001yoy.3_Missense_Mutation_p.R214C|INF2_uc001ypa.2_Missense_Mutation_p.R214C	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	214	GBD/FH3.		R -> H (in FSGS5).		actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CCTGCGCGCGCGCACCCAGCT	0.652													0	0	0	0.007291	0	28	130										T	105169764	C	T	105169764	3	4	6	1	0	0	0	0	1	0	0	0	7734	768	27	2	650	2	INF2	14	105169764	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1131800	105169764	2179776	537	1250										
INF2	64423	broad.mit.edu	37	chr14	105177451	105177451	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gacgccgacggcttcaagatCagcacattgctgaagctcac	10	13	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr14:105177451C>T	uc001ypb.2	+	15	2489	c.2346C>T	c.(2344-2346)ATC>ATT	p.I782I	INF2_uc010tyi.1_Silent_p.I782I|INF2_uc001ypc.2_Silent_p.I782I|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	782	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GCTTCAAGATCAGCACATTGC	0.667													0	0	0	0.009096	0	3	7										T	105177451	C	T	105177451	2	4	6	1	0	0	0	0	0	0	0	1	7734	816	29	1		1	INF2	14	105177451	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7687	105177451	2172089	538	1251										
CASC5	57082	broad.mit.edu	37	chr15	40920870	40920870	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actatttgtgaagagagcttGagggaggtatgttaaaattc	12	3	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:40920870G>C	uc010bbs.1	+	13	5816	c.5655G>C	c.(5653-5655)TTG>TTC	p.L1885F	CASC5_uc010bbt.1_Missense_Mutation_p.L1859F	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1885	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAGAGAGCTTGAGGGAGGTAT	0.308													0	0	0	0.013537	0	12	91										C	40920870	G	C	40920870	3	2	6	1	0	0	0	0	1	0	0	0	2663	1281	45	1	5701	1	CASC5	15	40920870	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		40920870	61610522	539	1252										
DLL4	54567	broad.mit.edu	37	chr15	41229093	41229093	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagtttccccacagtgacaaGagcttaggagagaaggcgcc	12	10	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:41229093G>C	uc001zng.1	+	9	2228	c.1908G>C	c.(1906-1908)AAG>AAC	p.K636N		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	636	Cytoplasmic (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		ACAGTGACAAGAGCTTAGGAG	0.612													0	0	0	0.006214	0	8	25										C	41229093	G	C	41229093	3	2	6	1	0	0	0	0	1	0	0	0	4568	933	33	1	1942	1	DLL4	15	41229093	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	308223	41229093	61302299	540	1253										
VPS39	23339	broad.mit.edu	37	chr15	42462051	42462051	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggtcagggtacaggcccatCacatgggtgggatctatatg	14	8	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:42462051C>T	uc001zpd.2	-	13	1288	c.1137G>A	c.(1135-1137)GTG>GTA	p.V379V	VPS39_uc001zpc.2_Silent_p.V368V	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	379					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		ACAGGCCCATCACATGGGTGG	0.468													0	0	0	0.00623	0	32	108										T	42462051	C	T	42462051	2	4	6	1	0	0	0	0	0	0	0	1	17206	813	29	1		1	VPS39	15	42462051	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1232958	42462051	60069341	541	1254										
GANC	2595	broad.mit.edu	37	chr15	42568597	42568597	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcagagactgtaacaagatCgcattttacaggtaaggaaa	9	6	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:42568597C>T	uc001zpi.2	+	2	395	c.81C>T	c.(79-81)ATC>ATT	p.I27I	GANC_uc001zph.2_Silent_p.I27I|GANC_uc001zpj.1_5'UTR|TMEM87A_uc010udd.1_5'Flank|TMEM87A_uc001zpf.3_5'Flank|TMEM87A_uc010bcu.1_5'Flank|TMEM87A_uc001zpg.2_5'Flank|GANC_uc010ude.1_Silent_p.I27I	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	27					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GTAACAAGATCGCATTTTACA	0.294													0	0	0	0.004672	0	3	31										T	42568597	C	T	42568597	2	4	6	1	0	0	0	0	0	0	0	1	6234	874	31	1		1	GANC	15	42568597	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	106546	42568597	59962795	542	1255										
PPIP5K1	9677	broad.mit.edu	37	chr15	43873500	43873500	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actggatatcgaatctctttCccctcactgtctcgttcaac	5	14	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:43873500C>T	uc001zrw.2	-	9	1047	c.864G>A	c.(862-864)GGG>GGA	p.G288G	PPIP5K1_uc001zrx.1_Silent_p.G288G|PPIP5K1_uc001zru.2_Silent_p.G288G|PPIP5K1_uc001zry.3_Silent_p.G288G|PPIP5K1_uc001zrv.2_Silent_p.G288G|PPIP5K1_uc001zrz.1_Silent_p.G288G|PPIP5K1_uc010udr.1_Silent_p.G288G	NM_001130858	NP_001124330	Q6PFW1	VIP1_HUMAN	histidine acid phosphatase domain containing 2A	288					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity				0						GAATCTCTTTCCCCTCACTGT	0.512													0	0	0	0.01441	0	52	259										T	43873500	C	T	43873500	2	4	6	1	0	0	0	0	0	0	0	1	12332	842	30	1		1	PPIP5K1	15	43873500	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1304903	43873500	58657892	543	1256										
TMOD2	29767	broad.mit.edu	37	chr15	52069173	52069173	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaacaatccaaagttcgatGaagaaacagccaacaataaa	5	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:52069173G>A	uc002abk.2	+	5	672	c.451G>A	c.(451-453)GAA>AAA	p.E151K	TMOD2_uc002abl.3_Missense_Mutation_p.E151K|TMOD2_uc010bfb.2_Missense_Mutation_p.E107K	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	151					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		AAAGTTCGATGAAGAAACAGC	0.418													0	0	0	0.004656	0	23	59										A	52069173	G	A	52069173	3	1	6	1	0	0	0	0	1	0	0	0	16231	1291	45	1	465	1	TMOD2	15	52069173	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8195673	52069173	50462219	544	1257										
WDR72	256764	broad.mit.edu	37	chr15	53908309	53908309	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctggaagagtcaacatcactGagtggagttggtagcaaaag	13	6	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:53908309G>C	uc002acj.2	-	15	2136	c.2094C>G	c.(2092-2094)CTC>CTG	p.L698L	WDR72_uc010bfi.1_Silent_p.L698L	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	698										lung(1)|skin(1)	2				all cancers(107;0.0511)		CAACATCACTGAGTGGAGTTG	0.408													0	0	0	0.004482	0	9	83										C	53908309	G	C	53908309	2	2	6	1	0	0	0	0	0	0	0	1	17319	1277	45	1		1	WDR72	15	53908309	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1839136	53908309	48623083	545	1258										
NEDD4	4734	broad.mit.edu	37	chr15	56130727	56130727	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgtccaaaaagttcttcatCtatgataaacctgaggtcca	6	10	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:56130727C>T	uc002adj.2	-	18	3664	c.3364G>A	c.(3364-3366)GAT>AAT	p.D1122N	NEDD4_uc002adl.2_Missense_Mutation_p.D703N|NEDD4_uc002adi.2_Missense_Mutation_p.D1050N|NEDD4_uc010ugj.1_Missense_Mutation_p.D1106N|NEDD4_uc010bfm.2_Missense_Mutation_p.D1105N|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	1122	HECT.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		AGTTCTTCATCTATGATAAAC	0.308													0	0	0	0.005443	0	21	66										T	56130727	C	T	56130727	3	4	6	1	0	0	0	0	1	0	0	0	10310	913	32	1	627	1	NEDD4	15	56130727	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2222418	56130727	46400665	546	1259										
SPG21	51324	broad.mit.edu	37	chr15	65255979	65255979	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cactactgctcctcctggctGatgccaaggctgcctttctg	9	15	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:65255979G>A	uc002aod.2	-	9	1002	c.909C>T	c.(907-909)ATC>ATT	p.I303I	SPG21_uc002aoe.2_Silent_p.I303I|SPG21_uc010bhb.2_Silent_p.I276I|SPG21_uc010bhc.2_Silent_p.I149I	NM_001127889	NP_001121361	Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 isoform a	303					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding				0						CCTCCTGGCTGATGCCAAGGC	0.527													0	0	0	0.01441	0	48	124										A	65255979	G	A	65255979	2	1	6	1	0	0	0	0	0	0	0	1	15042	1280	45	1		1	SPG21	15	65255979	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	9125252	65255979	37275413	547	1260										
C15orf44	81556	broad.mit.edu	37	chr15	65871820	65871820	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctggtcataagcggcatactCagaggtgccggtactggcca	13	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:65871820C>G	uc002apd.2	-	12	1819	c.1483G>C	c.(1483-1485)GAG>CAG	p.E495Q	C15orf44_uc010uix.1_Missense_Mutation_p.E531Q|C15orf44_uc010uiz.1_Missense_Mutation_p.E459Q|C15orf44_uc010uja.1_Missense_Mutation_p.E445Q|C15orf44_uc010ujb.1_Missense_Mutation_p.E416Q|C15orf44_uc002ape.3_Missense_Mutation_p.E495Q|C15orf44_uc010uiy.1_Missense_Mutation_p.E416Q	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	495										ovary(1)	1						GCGGCATACTCAGAGGTGCCG	0.532													0	0	0	0.004878	0	38	127										G	65871820	C	G	65871820	3	3	6	1	0	0	0	0	1	0	0	0	1798	835	29	1	77	1	C15orf44	15	65871820	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	615841	65871820	36659572	548	1261										
HCN4	10021	broad.mit.edu	37	chr15	73660074	73660074	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtgtccaccgagggctgctCgcaggaggcggaggccggct	19	12	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:73660074C>T	uc002avp.2	-	1	1532	c.538G>A	c.(538-540)GAG>AAG	p.E180K		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	180	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GAGGGCTGCTCGCAGGAGGCG	0.786													0	0	0	0.000602	0	5	12										T	73660074	C	T	73660074	3	4	6	1	0	0	0	0	1	0	0	0	6999	893	31	1	3105	1	HCN4	15	73660074	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7788254	73660074	28871318	549	1262										
TM6SF1	53346	broad.mit.edu	37	chr15	83776476	83776476	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtcttcgtgctgtccctctCggccatcccggtcacctatg	10	16	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:83776476C>G	uc002bjp.2	+	1	153	c.44C>G	c.(43-45)TCG>TGG	p.S15W	TM6SF1_uc010bmq.2_Missense_Mutation_p.S15W|TM6SF1_uc002bjq.2_Missense_Mutation_p.S15W|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	15	Helical; (Potential).					integral to membrane				ovary(1)	1						CTGTCCCTCTCGGCCATCCCG	0.567													0	0	0	0.000602	0	5	25										G	83776476	C	G	83776476	3	3	6	1	0	0	0	0	1	0	0	0	15969	893	31	1	46	1	TM6SF1	15	83776476	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	10116402	83776476	18754916	550	1263										
ACAN	176	broad.mit.edu	37	chr15	89398115	89398115	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttggcctcccactggcgcaGcaacagaggaaagtacagaa	11	12	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:89398115G>A	uc010upo.1	+	12	2673	c.2299G>A	c.(2299-2301)GCA>ACA	p.A767T	ACAN_uc010upp.1_Missense_Mutation_p.A767T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	767					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CACTGGCGCAGCAACAGAGGA	0.522													0	0	0	0.004672	0	3	19										A	89398115	G	A	89398115	3	1	6	1	0	0	0	0	1	0	0	0	117	971	34	2	2341	2	ACAN	15	89398115	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5621639	89398115	13133277	551	1264										
CRTC3	64784	broad.mit.edu	37	chr15	91083274	91083274	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatcactttgtttccaggttCaatttcagaagcttcagcaa	6	9	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:91083274C>G	uc002bpp.2	+	2	242	c.136C>G	c.(136-138)CAA>GAA	p.Q46E	CRTC3_uc002bpn.2_Missense_Mutation_p.Q46E|CRTC3_uc002bpo.2_Missense_Mutation_p.Q46E	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	46	Required for interaction with HTLV-1 TAX.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			TTTCCAGGTTCAATTTCAGAA	0.443			T	MAML2	salivary gland mucoepidermoid								0	0	0	0.004656	0	25	48										G	91083274	C	G	91083274	3	3	6	1	0	0	0	0	1	0	0	0	3901	827	29	1	142	1	CRTC3	15	91083274	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1685159	91083274	11448118	552	1265										
FURIN	5045	broad.mit.edu	37	chr15	91424753	91424753	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtggagcagacttgctcccGgcaaagccagagcagccgag	14	12	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr15:91424753G>A	uc002bpu.1	+	16	2246	c.2030G>A	c.(2029-2031)CGG>CAG	p.R677Q	FES_uc010uqj.1_5'Flank|FES_uc010uqk.1_5'Flank|FES_uc002bpw.2_5'Flank|FES_uc002bpv.2_5'Flank	NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	677	Cys-rich.				cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ACTTGCTCCCGGCAAAGCCAG	0.716													0	0	0	0.000602	0	4	22										A	91424753	G	A	91424753	3	1	6	1	0	0	0	0	1	0	0	0	6099	1116	39	2	2088	2	FURIN	15	91424753	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	341479	91424753	11106639	553	1266										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1756554	1756554	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acctagactcggtgctcagcGagaaccaggagcacgaggtg	14	11	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:1756554G>A	uc002cmk.2	+	1	334	c.214G>A	c.(214-216)GAG>AAG	p.E72K	MAPK8IP3_uc002cmi.1_Missense_Mutation_p.E72K|MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Missense_Mutation_p.E72K|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.E72K	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	72	Potential.				vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GGTGCTCAGCGAGAACCAGGA	0.637													0	0	0	0.013537	0	11	23										A	1756554	G	A	1756554	3	1	6	1	0	0	0	0	1	0	0	0	9286	1059	37	1	216	1	MAPK8IP3	16	1756554	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		1756554	88598199	554	1267										
PKD1	5310	broad.mit.edu	37	chr16	2159441	2159441	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgagccggcagccagcagGatctgaaaatggaccagctg	14	11	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:2159441G>A	uc002cos.1	-	15	5936	c.5727C>T	c.(5725-5727)ATC>ATT	p.I1909I	PKD1_uc002cot.1_Silent_p.I1909I	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1909	Extracellular (Potential).|PKD 15.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CAGCCAGCAGGATCTGAAAAT	0.701													0	0	0	0.004482	0	6	23										A	2159441	G	A	2159441	2	1	6	1	0	0	0	0	0	0	0	1	11963	1164	41	1		1	PKD1	16	2159441	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	402887	2159441	88195312	555	1268										
AMDHD2	51005	broad.mit.edu	37	chr16	2570863	2570863	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gacgagcggcgggactgcggGggccgcatcttggctcccgg	19	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:2570863G>A	uc002cqq.2	+	2	274	c.177G>A	c.(175-177)GGG>GGA	p.G59G	AMDHD2_uc002cqp.2_Silent_p.G59G|AMDHD2_uc010uwc.1_Silent_p.G59G|AMDHD2_uc010uwd.1_Intron	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	59					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						GGGACTGCGGGGGCCGCATCT	0.687													0	0	0	0.00308	0	4	33										A	2570863	G	A	2570863	2	1	6	1	0	0	0	0	0	0	0	1	568	1219	43	2		2	AMDHD2	16	2570863	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	411422	2570863	87783890	556	1269										
ZNF200	7752	broad.mit.edu	37	chr16	3273910	3273910	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tattacttctgctttcgggtCttacaggctgagtgggtttt	11	7	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:3273910C>G	uc002cuj.2	-	5	1802	c.1170G>C	c.(1168-1170)AAG>AAC	p.K390N	ZNF200_uc002cum.3_Missense_Mutation_p.K389N|ZNF200_uc010bti.2_Missense_Mutation_p.K389N|ZNF200_uc002cuk.2_Missense_Mutation_p.K390N|ZNF200_uc002cui.2_Missense_Mutation_p.K389N|ZNF200_uc002cul.3_Missense_Mutation_p.K389N	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCTTTCGGGTCTTACAGGCTG	0.483													0	0	0	0.01441	0	50	307										G	3273910	C	G	3273910	3	3	6	1	0	0	0	0	1	0	0	0	17759	912	32	1	21	1	ZNF200	16	3273910	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	703047	3273910	87080843	557	1270			2	4		4	4	88	C		1.493008e-09
ZNF200	7752	broad.mit.edu	37	chr16	3273931	3273931	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttacaggctgagtgggttttCtcatgccgggtacagtttga	13	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:3273931C>G	uc002cuj.2	-	5	1781	c.1149G>C	c.(1147-1149)GAG>GAC	p.E383D	ZNF200_uc002cum.3_Missense_Mutation_p.E382D|ZNF200_uc010bti.2_Missense_Mutation_p.E382D|ZNF200_uc002cuk.2_Missense_Mutation_p.E383D|ZNF200_uc002cui.2_Missense_Mutation_p.E382D|ZNF200_uc002cul.3_Missense_Mutation_p.E382D	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	383	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AGTGGGTTTTCTCATGCCGGG	0.478													0	0	0	0.01441	0	44	351										G	3273931	C	G	3273931	3	3	6	1	0	0	0	0	1	0	0	0	17759	912	32	1	42	1	ZNF200	16	3273931	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	21	3273931	87080822	558	1271			2	4		4	4	88	C		1.493008e-09
ZNF200	7752	broad.mit.edu	37	chr16	3273959	3273959	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggtacagtttgacagccgaCcaaatcttctcccacatttt	7	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:3273959C>G	uc002cuj.2	-	5	1753	c.1121G>C	c.(1120-1122)GGT>GCT	p.G374A	ZNF200_uc002cum.3_Missense_Mutation_p.G373A|ZNF200_uc010bti.2_Missense_Mutation_p.G373A|ZNF200_uc002cuk.2_Missense_Mutation_p.G374A|ZNF200_uc002cui.2_Missense_Mutation_p.G373A|ZNF200_uc002cul.3_Missense_Mutation_p.G373A	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	374	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TGACAGCCGACCAAATCTTCT	0.483													0	0	0	0.01441	0	46	418										G	3273959	C	G	3273959	3	3	6	1	0	0	0	0	1	0	0	0	17759	507	18	4	70	4	ZNF200	16	3273959	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	28	3273959	87080794	559	1272			2	4		4	4	88	C		1.493008e-09
ZNF200	7752	broad.mit.edu	37	chr16	3273997	3273997	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttttgcaaccatatggtctCtcagcctcatgactctgcag	7	12	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:3273997C>T	uc002cuj.2	-	5	1715	c.1083G>A	c.(1081-1083)GAG>GAA	p.E361E	ZNF200_uc002cum.3_Silent_p.E360E|ZNF200_uc010bti.2_Silent_p.E360E|ZNF200_uc002cuk.2_Silent_p.E361E|ZNF200_uc002cui.2_Silent_p.E360E|ZNF200_uc002cul.3_Silent_p.E360E	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CATATGGTCTCTCAGCCTCAT	0.453													0	0	0	0.01441	0	87	394										T	3273997	C	T	3273997	2	4	6	1	0	0	0	0	0	0	0	1	17759	912	32	1		1	ZNF200	16	3273997	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	38	3273997	87080756	560	1273			2	4		4	4	88	C		1.493008e-09
ZNF263	10127	broad.mit.edu	37	chr16	3339455	3339455	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctctgagaacatccaccctCaggtgctgcttcctgaccag	9	15	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:3339455C>T	uc002cuq.2	+	6	1281	c.949C>T	c.(949-951)CAG>TAG	p.Q317*	ZNF263_uc010uww.1_5'UTR|ZNF263_uc002cur.2_5'UTR	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	317					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						CATCCACCCTCAGGTGCTGCT	0.562													0	0	0	0.01441	0	45	163										T	3339455	C	T	3339455	4	4	6	1	0	0	0	0	0	1	0	0	17800	827	29	1	971	1	ZNF263	16	3339455	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	65458	3339455	87015298	561	1274										
BTBD12	84464	broad.mit.edu	37	chr16	3656547	3656547	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgcagcctcgagggagcactCttctgaagcgtgtctcaaac	11	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:3656547C>T	uc002cvp.2	-	3	1315	c.688G>A	c.(688-690)GAG>AAG	p.E230K	BTBD12_uc002cvq.1_Missense_Mutation_p.E230K	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	230	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						AGGGAGCACTCTTCTGAAGCG	0.542								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.01441	0	81	268										T	3656547	C	T	3656547	3	4	6	1	0	0	0	0	1	0	0	0	1540	922	32	1	4868	1	BTBD12	16	3656547	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	317092	3656547	86698206	562	1275										
GLIS2	84662	broad.mit.edu	37	chr16	4382347	4382347	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagctccgggcggcaagagaGaagcgggagaggacgctggg	20	8	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:4382347G>C	uc002cwc.1	+	1	123	c.66G>C	c.(64-66)GAG>GAC	p.E22D		NM_032575	NP_115964	Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	22					cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding				0						CGGCAAGAGAGAAGCGGGAGA	0.682													0	0	0	0.001855	0	10	40										C	4382347	G	C	4382347	3	2	6	1	0	0	0	0	1	0	0	0	6446	933	33	1	68	1	GLIS2	16	4382347	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	725800	4382347	85972406	563	1276										
CORO7	79585	broad.mit.edu	37	chr16	4412079	4412079	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcactctcaccaggtgtggtGaggttgagccccttgaggtt	13	10	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:4412079G>A	uc002cwh.3	-	16	1605	c.1485C>T	c.(1483-1485)CTC>CTT	p.L495L	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Silent_p.L495L|CORO7_uc002cwg.3_Silent_p.L275L|CORO7_uc010uxh.1_Silent_p.L477L|CORO7_uc010uxi.1_Silent_p.L410L|CORO7_uc002cwi.1_Silent_p.L275L|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_Silent_p.L275L	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	495						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						CAGGTGTGGTGAGGTTGAGCC	0.642													0	0	0	0.008871	0	12	46										A	4412079	G	A	4412079	2	1	6	1	0	0	0	0	0	0	0	1	3759	1277	45	1		1	CORO7	16	4412079	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	29732	4412079	85942674	564	1277										
PPL	5493	broad.mit.edu	37	chr16	4933745	4933745	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gccacggagcccaggcgcttCtgcagctcgtcgatctcgag	13	15	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:4933745C>T	uc002cyd.1	-	22	5001	c.4911G>A	c.(4909-4911)CAG>CAA	p.Q1637Q		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1637	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CCAGGCGCTTCTGCAGCTCGT	0.632													0	0	0	0.007413	0	16	53										T	4933745	C	T	4933745	2	4	6	1	0	0	0	0	0	0	0	1	12334	912	32	1		1	PPL	16	4933745	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	521666	4933745	85421008	565	1278										
RSL1D1	26156	broad.mit.edu	37	chr16	11940562	11940562	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaaacttacttctttctttGatagaaatgtctcccaatga	5	8	3	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:11940562G>C	uc002dbp.1	-	4	596	c.523C>G	c.(523-525)CAA>GAA	p.Q175E	RSL1D1_uc010buv.1_Missense_Mutation_p.Q175E|RSL1D1_uc010uyw.1_Translation_Start_Site|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	175					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TTCTTTCTTTGATAGAAATGT	0.413													0	0	0	0.01441	0	85	262										C	11940562	G	C	11940562	3	2	6	1	0	0	0	0	1	0	0	0	13700	1299	45	1	973	1	RSL1D1	16	11940562	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7006817	11940562	78414191	566	1279										
EARS2	124454	broad.mit.edu	37	chr16	23543988	23543988	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccccactcacctgttgaattCtgggagcttctccaggtcca	8	15	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:23543988C>T	uc002dlt.3	-	5	1089	c.1057G>A	c.(1057-1059)GAA>AAA	p.E353K	EARS2_uc002dlr.3_RNA|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Missense_Mutation_p.E353K	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	353					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	CTGTTGAATTCTGGGAGCTTC	0.512													0	0	0	0.003163	0	15	48										T	23543988	C	T	23543988	3	4	6	1	0	0	0	0	1	0	0	0	4878	922	32	1	534	1	EARS2	16	23543988	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	11603426	23543988	66810765	567	1280										
DCTN5	84516	broad.mit.edu	37	chr16	23669929	23669929	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agtgtcataaggccaccattCaagaagttcagcaaagggta	10	8	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:23669929C>G	uc002dly.1	+	3	276	c.219C>G	c.(217-219)TTC>TTG	p.F73L		NM_032486	NP_115875	Q9BTE1	DCTN5_HUMAN	dynactin 5	73						centrosome	transferase activity			upper_aerodigestive_tract(1)	1				GBM - Glioblastoma multiforme(48;0.0156)		GGCCACCATTCAAGAAGTTCA	0.423													0	0	0	0.004878	0	36	109										G	23669929	C	G	23669929	3	3	6	1	0	0	0	0	1	0	0	0	4310	825	29	1	229	1	DCTN5	16	23669929	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	125941	23669929	66684824	568	1281										
ERN2	10595	broad.mit.edu	37	chr16	23706204	23706204	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctgcccaggccctggctgtCaggcccggtgatgagaatat	13	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:23706204C>G	uc002dma.3	-	17	2258	c.2089G>C	c.(2089-2091)GAC>CAC	p.D697H	ERN2_uc010bxp.2_Missense_Mutation_p.D645H	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	649	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCCTGGCTGTCAGGCCCGGTG	0.627													0	0	0	0.003163	0	15	48										G	23706204	C	G	23706204	3	3	6	1	0	0	0	0	1	0	0	0	5238	826	29	1	859	1	ERN2	16	23706204	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	36275	23706204	66648549	569	1282										
SEZ6L2	26470	broad.mit.edu	37	chr16	29883590	29883590	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcccgagaagccgaaaaggGactttccctgaagcctggga	13	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:29883590G>A	uc002duq.3	-	16	2861	c.2621C>T	c.(2620-2622)TCC>TTC	p.S874F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.S817F|SEZ6L2_uc002dur.3_Missense_Mutation_p.S804F|SEZ6L2_uc002dus.3_Missense_Mutation_p.S773F|SEZ6L2_uc010vec.1_Missense_Mutation_p.S887F|SEZ6L2_uc010ved.1_Missense_Mutation_p.S843F	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	874	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GCCGAAAAGGGACTTTCCCTG	0.602													0	0	0	0.013537	0	11	54										A	29883590	G	A	29883590	3	1	6	1	0	0	0	0	1	0	0	0	14144	1174	41	1	119	1	SEZ6L2	16	29883590	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6177386	29883590	60471163	570	1283										
FUS	2521	broad.mit.edu	37	chr16	31195651	31195651	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcaaagctataatccccctCagggctatggacagcagaac	9	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:31195651C>T	uc002ebf.2	+	5	540	c.457C>T	c.(457-459)CAG>TAG	p.Q153*	FUS_uc002ebe.1_Nonsense_Mutation_p.Q153*|FUS_uc002ebh.2_Nonsense_Mutation_p.Q152*|FUS_uc002ebg.2_5'UTR|FUS_uc002ebi.2_Nonsense_Mutation_p.Q153*|FUS_uc002ebj.2_5'UTR|FUS_uc002ebk.1_5'Flank	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	153	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TAATCCCCCTCAGGGCTATGG	0.453			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								0	0	0	0.012213	0	33	109										T	31195651	C	T	31195651	4	4	6	1	0	0	0	0	0	1	0	0	6100	827	29	1	475	1	FUS	16	31195651	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1312061	31195651	59159102	571	1284										
ADCY7	113	broad.mit.edu	37	chr16	50346030	50346030	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttgagaccatggagaacgtGaaccgccttcttctggagaa	11	9	2	4	rs138338317	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:50346030G>A	uc002egd.1	+	20	2800	c.2532G>A	c.(2530-2532)GTG>GTA	p.V844V		NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	844	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TGGAGAACGTGAACCGCCTTC	0.552													0	0	0	0.006999	0	39	93										A	50346030	G	A	50346030	2	1	6	1	0	0	0	0	0	0	0	1	299	1277	45	1		1	ADCY7	16	50346030	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	19150379	50346030	40008723	572	1285										
BRD7	29117	broad.mit.edu	37	chr16	50384019	50384019	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgggtgtttaatgatcatgGagtagccaggagcaataaaa	12	4	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:50384019G>C	uc002egf.1	-	6	573	c.506C>G	c.(505-507)TCC>TGC	p.S169C	BRD7_uc002ege.1_Missense_Mutation_p.S169C	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	169	Bromo.				cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				AATGATCATGGAGTAGCCAGG	0.328													0	0	0	0.014323	0	24	77										C	50384019	G	C	50384019	3	2	6	1	0	0	0	0	1	0	0	0	1505	1174	41	1	1504	1	BRD7	16	50384019	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	37989	50384019	39970734	573	1286										
RSPRY1	89970	broad.mit.edu	37	chr16	57269103	57269103	+	Missense_Mutation	SNP	G	G	A													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgttccctttgttgtgatGaggtagcagacacacaattg							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:57269103G>A	uc002elb.2	+	14	1875	c.1597G>A	c.(1597-1599)GAG>AAG	p.E533K	RSPRY1_uc002elc.2_Missense_Mutation_p.E533K|RSPRY1_uc002eld.2_Missense_Mutation_p.E533K	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	533	RING-type.					extracellular region	zinc ion binding			ovary(1)	1						TTGTTGTGATGAGGTAGCAGA	0.403													0	0	0	0.00499	0	15	44										A	57269103	G	A	57269103	3	1	6	1	0	0	0	0	1	0	0	0	13713	1291	45	1	1647	1	RSPRY1	16	57269103	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6885084	57269103	33085650	574	1287	8	2								
RSPRY1	89970	broad.mit.edu	37	chr16	57269112	57269112	+	Missense_Mutation	SNP	G	G	A													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttgttgtgatgaggtagcaGacacacaattgaagccatgt							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:57269112G>A	uc002elb.2	+	14	1884	c.1606G>A	c.(1606-1608)GAC>AAC	p.D536N	RSPRY1_uc002elc.2_Missense_Mutation_p.D536N|RSPRY1_uc002eld.2_Missense_Mutation_p.D536N	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	536	RING-type.					extracellular region	zinc ion binding			ovary(1)	1						TGAGGTAGCAGACACACAATT	0.423													0	0	0	0.00245	0	12	43										A	57269112	G	A	57269112	3	1	6	1	0	0	0	0	1	0	0	0	13713	942	33	1	1656	1	RSPRY1	16	57269112	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	9	57269112	33085641	575	1288	8	2								
ARL2BP	23568	broad.mit.edu	37	chr16	57283691	57283691	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgttgcagatttctttggtaGaaaaatacattgaagaacag	9	4	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:57283691G>A	uc002elf.1	+	4	462	c.220G>A	c.(220-222)GAA>AAA	p.E74K	ARL2BP_uc010vhl.1_Missense_Mutation_p.E74K	NM_012106	NP_036238	Q9Y2Y0	AR2BP_HUMAN	binder of Arl Two	74				E->A: Decreases interaction with ARL2.	maintenance of protein location in nucleus|positive regulation of tyrosine phosphorylation of Stat3 protein|signal transduction	centrosome|midbody|mitochondrial intermembrane space|nucleus|spindle	protein binding|small GTPase regulator activity|transcription coactivator activity				0						TTCTTTGGTAGAAAAATACAT	0.418													0	0	0	0.012319	0	21	118										A	57283691	G	A	57283691	3	1	6	1	0	0	0	0	1	0	0	0	934	943	33	1	234	1	ARL2BP	16	57283691	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14579	57283691	33071062	576	1289										
CNGB1	1258	broad.mit.edu	37	chr16	57918280	57918280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgtccggggcgcgggtgggtCggtggcggcctcctttgggt	21	11	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:57918280C>T	uc002emt.2	-	33	3609	c.3544G>A	c.(3544-3546)GAC>AAC	p.D1182N	CNGB1_uc010cdh.2_Missense_Mutation_p.D1176N	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1182	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GCGGGTGGGTCGGTGGCGGCC	0.721													0	0	0	0.006214	0	9	31										T	57918280	C	T	57918280	3	4	6	1	0	0	0	0	1	0	0	0	3600	884	31	1	215	1	CNGB1	16	57918280	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	634589	57918280	32436473	577	1290										
ZDHHC1	29800	broad.mit.edu	37	chr16	67428988	67428988	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcagagacacgggggagcctGagggccccacatcgccaaaa	14	13	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:67428988G>C	uc010vjm.1	-	10	1451	c.1147C>G	c.(1147-1149)CAG>GAG	p.Q383E	TPPP3_uc002eta.2_5'Flank|TPPP3_uc002etb.2_5'Flank	NM_013304	NP_037436	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	383						integral to membrane	DNA binding|zinc ion binding				0		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GGGGGAGCCTGAGGGCCCCAC	0.617													0	0	0	0.000602	0	4	28										C	67428988	G	C	67428988	3	2	6	1	0	0	0	0	1	0	0	0	17597	1299	45	1	318	1	ZDHHC1	16	67428988	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	9510708	67428988	22925765	578	1291										
CTCF	10664	broad.mit.edu	37	chr16	67662356	67662356	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcgataagaccttccgccaGaagcagcttctcgacatgca	9	13	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:67662356G>A	uc002etl.2	+	9	1892	c.1602G>A	c.(1600-1602)CAG>CAA	p.Q534Q	CTCF_uc010cek.2_Silent_p.Q206Q|CTCF_uc002etm.1_Silent_p.Q23Q	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	534	C2H2-type 10.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CCTTCCGCCAGAAGCAGCTTC	0.557													0	0	0	0.008361	0	29	87										A	67662356	G	A	67662356	2	1	6	1	0	0	0	0	0	0	0	1	4000	933	33	1		1	CTCF	16	67662356	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	233368	67662356	22692397	579	1292										
VAC14	55697	broad.mit.edu	37	chr16	70817025	70817025	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taatttcttttaagaattctCcaagaacaacctcacaccta	2	11	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:70817025C>G	uc002ezm.2	-	7	980	c.722G>C	c.(721-723)GGA>GCA	p.G241A	VAC14_uc010cfw.2_Missense_Mutation_p.G7A|VAC14_uc002ezn.2_Intron	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	241	HEAT 4.				interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				TAAGAATTCTCCAAGAACAAC	0.498													0	0	0	0.00623	0	36	109										G	70817025	C	G	70817025	3	3	6	1	0	0	0	0	1	0	0	0	17108	855	30	1	1678	1	VAC14	16	70817025	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3154669	70817025	19537728	580	1293										
CHST6	4166	broad.mit.edu	37	chr16	75512842	75512842	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caggcctcgagctgtggcgtGagactgagcccagtgaaggc	16	11	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:75512842G>A	uc002fef.2	-	3	1065	c.885C>T	c.(883-885)CTC>CTT	p.L295L	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.L295L	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	295	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCTGTGGCGTGAGACTGAGCC	0.647													0	0	0	0.003163	0	14	58										A	75512842	G	A	75512842	2	1	6	1	0	0	0	0	0	0	0	1	3408	1277	45	1		1	CHST6	16	75512842	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4695817	75512842	14841911	581	1294										
PLCG2	5336	broad.mit.edu	37	chr16	81934316	81934316	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttggcgacctgctgttgacGaagcccacggaggccagtgc	14	12	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:81934316G>A	uc002fgt.2	+	14	1445	c.1293G>A	c.(1291-1293)ACG>ACA	p.T431T	PLCG2_uc010chg.1_Silent_p.T431T	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	431	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TGCTGTTGACGAAGCCCACGG	0.612													0	0	0	0.007413	0	19	54										A	81934316	G	A	81934316	2	1	6	1	0	0	0	0	0	0	0	1	12036	1045	37	1		1	PLCG2	16	81934316	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6421474	81934316	8420437	582	1295										
SPG7	6687	broad.mit.edu	37	chr16	89598329	89598329	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagagcccagaacgcttcctCcagcttggcgccaaggtccc	10	17	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:89598329C>G	uc002fnj.2	+	8	1026	c.1005C>G	c.(1003-1005)CTC>CTG	p.L335L	SPG7_uc002fni.2_Silent_p.L335L	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	335	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		AACGCTTCCTCCAGCTTGGCG	0.532													0	0	0	0.001984	0	6	59										G	89598329	C	G	89598329	2	3	6	1	0	0	0	0	0	0	0	1	15043	842	30	1		1	SPG7	16	89598329	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7664013	89598329	756424	583	1296										
TUBB3	10381	broad.mit.edu	37	chr16	89998985	89998985	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cactttgtttgcagttctggGaagtcatcagtgatgagcat	11	7	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr16:89998985G>A	uc002fph.1	+	2	129	c.64G>A	c.(64-66)GAA>AAA	p.E22K	TUBB3_uc002fpf.2_Missense_Mutation_p.E369K|TUBB3_uc010ciz.1_5'UTR|TUBB3_uc010cja.1_RNA|TUBB3_uc002fpg.1_5'UTR|TUBB3_uc002fpi.1_5'UTR|TUBB3_uc002fpj.1_5'UTR|TUBB3_uc010cjb.1_5'UTR|TUBB3_uc002fpk.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	22					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GCAGTTCTGGGAAGTCATCAG	0.587													0	0	0	0.003163	0	14	53										A	89998985	G	A	89998985	3	1	6	1	0	0	0	0	1	0	0	0	16754	1175	41	1	70	1	TUBB3	16	89998985	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	400656	89998985	355768	584	1297										
TRPV3	162514	broad.mit.edu	37	chr17	3458046	3458046	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcttctttgtgggggtgatCtccgccggcctcttctctgg	12	13	5	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:3458046C>T	uc002fvt.1	-	2	421	c.99G>A	c.(97-99)GAG>GAA	p.E33E	TRPV3_uc010vrj.1_5'UTR|TRPV3_uc010vrk.1_RNA|TRPV3_uc002fvr.2_Silent_p.E33E|TRPV3_uc002fvu.2_Silent_p.E33E	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	33	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	TGGGGGTGATCTCCGCCGGCC	0.657													0	0	0	0.008871	0	19	68										T	3458046	C	T	3458046	2	4	6	1	0	0	0	0	0	0	0	1	16594	912	32	1		1	TRPV3	17	3458046	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		3458046	77737164	585	1298										
ALOX15	246	broad.mit.edu	37	chr17	4544957	4544957	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agagacccatcttgctcaaaGatgtttcgctccttctggtg	9	11	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:4544957G>C	uc002fyh.2	-	1	4	c.-10C>G	c.(-12--8)ATCTT>ATGTT		ALOX15_uc010vsd.1_Translation_Start_Site|ALOX15_uc010vse.1_Missense_Mutation_p.S19C	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase						inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	CTTGCTCAAAGATGTTTCGCT	0.612													0	0	0	0.00245	0	15	52										C	4544957	G	C	4544957	1	2	6	1	0	0	0	0	0	0	0	0	538	957	33	1		1	ALOX15	17	4544957	Translation_Start_Site	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1086911	4544957	76650253	586	1299										
CAMTA2	23125	broad.mit.edu	37	chr17	4877697	4877697	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacctgaactggaggagcatCaggaccctggcaaggcacct	12	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:4877697C>T	uc002gah.1	-	12	2107	c.1999G>A	c.(1999-2001)GAT>AAT	p.D667N	CAMTA2_uc010cku.1_Missense_Mutation_p.D690N|CAMTA2_uc002gag.1_Missense_Mutation_p.D666N|CAMTA2_uc002gai.1_Missense_Mutation_p.D669N|CAMTA2_uc010ckv.1_Missense_Mutation_p.D314N	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	667					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGAGGAGCATCAGGACCCTGG	0.572													0	0	0	0.014323	0	21	103										T	4877697	C	T	4877697	3	4	6	1	0	0	0	0	1	0	0	0	2614	826	29	1	1707	1	CAMTA2	17	4877697	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	332740	4877697	76317513	587	1300										
KIF1C	10749	broad.mit.edu	37	chr17	4904541	4904541	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggacccccagtttgcatctCagcagcaagtgtatcgggac	11	12	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:4904541C>T	uc002gan.1	+	5	534	c.208C>T	c.(208-210)CAG>TAG	p.Q70*		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	70	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GTTTGCATCTCAGCAGCAAGT	0.527													0	0	0	0.004289	0	35	117										T	4904541	C	T	4904541	4	4	6	1	0	0	0	0	0	1	0	0	8285	827	29	1	218	1	KIF1C	17	4904541	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	26844	4904541	76290669	588	1301										
KIF1C	10749	broad.mit.edu	37	chr17	4905849	4905849	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggtccgggagcaccccatcCtgggcccgtacgtgcaggac	15	15	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:4905849C>T	uc002gan.1	+	7	846	c.520C>T	c.(520-522)CTG>TTG	p.L174L		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	174	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GCACCCCATCCTGGGCCCGTA	0.577													0	0	0	0.013114	0	46	174										T	4905849	C	T	4905849	2	4	6	1	0	0	0	0	0	0	0	1	8285	680	24	2		2	KIF1C	17	4905849	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1308	4905849	76289361	589	1302										
KIF1C	10749	broad.mit.edu	37	chr17	4925875	4925875	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggggcggaggtggaggacctCcgggcccacatcgacaagct	17	12	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:4925875C>G	uc002gan.1	+	22	2825	c.2499C>G	c.(2497-2499)CTC>CTG	p.L833L		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	833	Potential.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						TGGAGGACCTCCGGGCCCACA	0.672													0	0	0	0.000602	0	5	12										G	4925875	C	G	4925875	2	3	6	1	0	0	0	0	0	0	0	1	8285	842	30	1		1	KIF1C	17	4925875	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	20026	4925875	76269335	590	1303										
STX8	9482	broad.mit.edu	37	chr17	9448576	9448576	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gatcatccaagaggttctgtCttcggtccccttcaagctgt	9	12	4	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:9448576C>T	uc002glx.2	-	4	386	c.236G>A	c.(235-237)AGA>AAA	p.R79K		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8	79	Cytoplasmic (Potential).				transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						GAGGTTCTGTCTTCGGTCCCC	0.398													0	0	0	0.009535	0	26	102										T	9448576	C	T	9448576	3	4	6	1	0	0	0	0	1	0	0	0	15350	913	32	1	494	1	STX8	17	9448576	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4522701	9448576	71746634	591	1304										
DNAH9	1770	broad.mit.edu	37	chr17	11865486	11865486	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgcaatgtgacatgacgaaGaagaacagagaagagtttag	12	5	0	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:11865486G>C	uc002gne.2	+	68	13214	c.13146G>C	c.(13144-13146)AAG>AAC	p.K4382N	DNAH9_uc010coo.2_Missense_Mutation_p.K3600N|DNAH9_uc002gnf.2_Missense_Mutation_p.K694N	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	4382					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACATGACGAAGAAGAACAGAG	0.547													0	0	0	0.010504	0	21	82										C	11865486	G	C	11865486	3	2	6	1	0	0	0	0	1	0	0	0	4608	933	33	1	13416	1	DNAH9	17	11865486	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2416910	11865486	69329724	592	1305										
FLCN	201163	broad.mit.edu	37	chr17	17116970	17116970	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcaggtgtgtgtgacgggtCagttccgagactccgaggct	17	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:17116970C>G	uc002gra.3	-	14	2243	c.1739G>C	c.(1738-1740)TGA>TCA	p.*580S	PLD6_uc010cpn.2_Intron	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	580					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						TGTGACGGGTCAGTTCCGAGA	0.582									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				0	0	0	0.013726	0	33	104										G	17116970	C	G	17116970	4	3	6	1	0	0	0	0	0	0	0	0	5921	837	29	1	4	1	FLCN	17	17116970	Nonstop_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5251484	17116970	64078240	593	1306										
ULK2	9706	broad.mit.edu	37	chr17	19689261	19689261	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctccttacctgaggttgttCttgttcgaaggaacatgtgg	12	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:19689261C>G	uc002gwm.3	-	21	2749	c.2240G>C	c.(2239-2241)AGA>ACA	p.R747T	ULK2_uc002gwn.2_Missense_Mutation_p.R747T	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	747					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TGAGGTTGTTCTTGTTCGAAG	0.408													0	0	0	0.007413	0	18	58										G	19689261	C	G	19689261	3	3	6	1	0	0	0	0	1	0	0	0	16973	913	32	1	898	1	ULK2	17	19689261	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2572291	19689261	61505949	594	1307										
KIAA0100	9703	broad.mit.edu	37	chr17	26945942	26945942	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcacatcttcttgctgctttCgcagctccatcttgttagcc	6	14	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:26945942C>T	uc002hbu.2	-	32	5789	c.5690G>A	c.(5689-5691)CGA>CAA	p.R1897Q	KIAA0100_uc002hbt.2_Missense_Mutation_p.R226Q	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1897						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTGCTGCTTTCGCAGCTCCAT	0.527													0	0	0	0.014323	0	18	71										T	26945942	C	T	26945942	3	4	6	1	0	0	0	0	1	0	0	0	8154	884	31	1	1049	1	KIAA0100	17	26945942	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7256681	26945942	54249268	595	1308										
CORO6	84940	broad.mit.edu	37	chr17	27945892	27945892	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcaggctaccgttgctgttCcagcacacactgtggatgac	11	12	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:27945892C>T	uc002hel.2	-	4	551	c.549G>A	c.(547-549)TGG>TGA	p.W183*	CORO6_uc002hem.2_5'Flank|CORO6_uc002hen.2_5'Flank	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	183	WD 3.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CGTTGCTGTTCCAGCACACAC	0.577													0	0	0	0.014323	0	24	75										T	27945892	C	T	27945892	4	4	6	1	0	0	0	0	0	1	0	0	3758	856	30	1	897	1	CORO6	17	27945892	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	999950	27945892	53249318	596	1309										
RAB11FIP4	84440	broad.mit.edu	37	chr17	29850554	29850554	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcatgcacagcagcaacttCagcagcagcaatggcagcac	9	14	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:29850554C>A	uc002hgn.1	+	8	1183	c.954C>A	c.(952-954)TTC>TTA	p.F318L	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.F216L	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	318	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GCAGCAACTTCAGCAGCAGCA	0.602													1	0	6.84511e-11	0.003271	7.02684e-11	34	113										A	29850554	C	A	29850554	3	1	6	1	0	0	0	0	1	0	0	0	12896	825	29	3	984	3	RAB11FIP4	17	29850554	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1904662	29850554	51344656	597	1310										
SPACA3	124912	broad.mit.edu	37	chr17	31318969	31318969	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgtcaccatggtctcagctCtgcggggagcacccctgatc	11	14	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:31318969C>T	uc002hhs.1	+	1	88	c.13C>T	c.(13-15)CTG>TTG	p.L5L	SPACA3_uc010cte.1_5'Flank	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	5	Cytoplasmic (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			GGTCTCAGCTCTGCGGGGAGC	0.607													0	0	0	0.00308	0	4	33										T	31318969	C	T	31318969	2	4	6	1	0	0	0	0	0	0	0	1	14973	912	32	1		1	SPACA3	17	31318969	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1468415	31318969	49876241	598	1311										
UNC45B	146862	broad.mit.edu	37	chr17	33507615	33507615	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agagggccttgccagacatcGagaactacatgtttgagaat	11	8	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:33507615G>A	uc002hja.2	+	18	2396	c.2299G>A	c.(2299-2301)GAG>AAG	p.E767K	UNC45B_uc002hjb.2_Missense_Mutation_p.E765K|UNC45B_uc002hjc.2_Missense_Mutation_p.E765K|UNC45B_uc010cto.2_Missense_Mutation_p.E686K	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	767	ARM 3.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GCCAGACATCGAGAACTACAT	0.547													0	0	0	0.004007	0	15	66										A	33507615	G	A	33507615	3	1	6	1	0	0	0	0	1	0	0	0	16986	1059	37	1	2365	1	UNC45B	17	33507615	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2188646	33507615	47687595	599	1312										
CCL3	6348	broad.mit.edu	37	chr17	34416051	34416051	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccaggtcgctgacatatttCtggacccactcctcactggg	9	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:34416051C>G	uc002hkv.2	-	3	348	c.246G>C	c.(244-246)CAG>CAC	p.Q82H		NM_002983	NP_002974	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	82					cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGACATATTTCTGGACCCACT	0.617													0	0	0	0.010771	0	43	161										G	34416051	C	G	34416051	3	3	6	1	0	0	0	0	1	0	0	0	2901	912	32	1	36	1	CCL3	17	34416051	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	908436	34416051	46779159	600	1313										
DUSP14	11072	broad.mit.edu	37	chr17	35872727	35872727	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgctgcaggggtgagccgctCagccacgctgtgtatcgcgt	15	12	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:35872727C>G	uc002hnx.2	+	3	647	c.353C>G	c.(352-354)TCA>TGA	p.S118*	DUSP14_uc002hny.2_Nonsense_Mutation_p.S105*|DUSP14_uc002hnz.2_Nonsense_Mutation_p.S105*	NM_007026	NP_008957	O95147	DUS14_HUMAN	dual specificity phosphatase 14	118	Tyrosine-protein phosphatase.						MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Breast(25;0.00637)|Ovarian(249;0.15)				GTGAGCCGCTCAGCCACGCTG	0.592													0	0	0	0.003163	0	13	63										G	35872727	C	G	35872727	4	3	6	1	0	0	0	0	0	1	0	0	4814	838	29	1	355	1	DUSP14	17	35872727	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1456676	35872727	45322483	601	1314										
CDK12	51755	broad.mit.edu	37	chr17	37618767	37618767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcgatgaaggaccggatatCgggaagttcaaagcgttcga	13	7	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:37618767C>T	uc010cvv.2	+	1	1029	c.443C>T	c.(442-444)TCG>TTG	p.S148L	CDK12_uc010wef.1_Missense_Mutation_p.S148L|CDK12_uc002hrw.3_Missense_Mutation_p.S148L	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	148					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GACCGGATATCGGGAAGTTCA	0.502										TCGA Ovarian(9;0.13)			0	0	0	0.008871	0	21	77										T	37618767	C	T	37618767	3	4	6	1	0	0	0	0	1	0	0	0	3128	893	31	1	445	1	CDK12	17	37618767	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1746040	37618767	43576443	602	1315										
ERBB2	2064	broad.mit.edu	37	chr17	37884259	37884259	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaaagggacacctacggcaGagaacccagagtacctgggt	12	11	1	2	rs144533600	by1000genomes	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:37884259G>C	uc002hso.2	+	27	3968	c.3730G>C	c.(3730-3732)GAG>CAG	p.E1244Q	ERBB2_uc002hsm.2_Missense_Mutation_p.E1214Q|ERBB2_uc010cwa.2_Missense_Mutation_p.E1229Q|ERBB2_uc002hsp.2_Missense_Mutation_p.E1047Q|ERBB2_uc010cwb.2_3'UTR|ERBB2_uc010wek.1_Missense_Mutation_p.E968Q	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1244	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ACCTACGGCAGAGAACCCAGA	0.607		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.003954	0	22	66										C	37884259	G	C	37884259	3	2	6	1	0	0	0	0	1	0	0	0	5206	943	33	1	3836	1	ERBB2	17	37884259	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	265492	37884259	43310951	603	1316										
CASC3	22794	broad.mit.edu	37	chr17	38319905	38319905	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tattctcgatctgggggcttCaaggaaggtcgtgctggttt	14	7	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:38319905C>T	uc010cwt.1	+	7	1252	c.957C>T	c.(955-957)TTC>TTT	p.F319F	CASC3_uc010cws.1_Silent_p.F319F|CASC3_uc002hue.2_Silent_p.F319F	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	319					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						CTGGGGGCTTCAAGGAAGGTC	0.547													0	0	0	0.01441	0	96	330										T	38319905	C	T	38319905	2	4	6	1	0	0	0	0	0	0	0	1	2661	825	29	1		1	CASC3	17	38319905	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	435646	38319905	42875305	604	1317										
RARA	5914	broad.mit.edu	37	chr17	38512341	38512341	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggaaatgttggagaactcaGagggcctggacactctgagc	14	8	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:38512341G>A	uc002huk.1	+	9	1707	c.1252G>A	c.(1252-1254)GAG>AAG	p.E418K	RARA_uc002hul.3_Missense_Mutation_p.E418K|RARA_uc010wfe.1_Missense_Mutation_p.E321K|RARA_uc002hun.1_Missense_Mutation_p.E413K	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	418	Ligand-binding.|Required for binding corepressor NCOR1.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	GGAGAACTCAGAGGGCCTGGA	0.617			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								0	0	0	0.004672	0	3	20										A	38512341	G	A	38512341	3	1	6	1	0	0	0	0	1	0	0	0	13052	943	33	1	1449	1	RARA	17	38512341	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	192436	38512341	42682869	605	1318										
CCR7	1236	broad.mit.edu	37	chr17	38711549	38711549	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctctggaggtcactgtacagGagctctgggatggagagcac	15	9	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:38711549G>C	uc002huw.2	-	3	645	c.582C>G	c.(580-582)CTC>CTG	p.L194L		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	194	Extracellular (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				CACTGTACAGGAGCTCTGGGA	0.582													0	0	0	0.012319	0	20	34										C	38711549	G	C	38711549	2	2	6	1	0	0	0	0	0	0	0	1	2946	1161	41	1		1	CCR7	17	38711549	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	199208	38711549	42483661	606	1319										
KRT31	3881	broad.mit.edu	37	chr17	39550344	39550344	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agggggcaggagggacacaaGaggtacagggattggagaga	20	4	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:39550344G>C	uc002hwn.2	-	7	1228	c.1175C>G	c.(1174-1176)TCT>TGT	p.S392C	KRT31_uc010cxn.2_3'UTR	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	392	Tail.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				AGGGACACAAGAGGTACAGGG	0.612													0	0	0	0.010818	0	33	108										C	39550344	G	C	39550344	3	2	6	1	0	0	0	0	1	0	0	0	8467	942	33	1	79	1	KRT31	17	39550344	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	838795	39550344	41644866	607	1320										
DHX58	79132	broad.mit.edu	37	chr17	40260106	40260106	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atttggtccatgagcttcttCagcaagtccccaaacggatc	8	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:40260106C>T	uc002hyw.3	-	7	922	c.699G>A	c.(697-699)CTG>CTA	p.L233L	DHX58_uc002hyv.3_RNA|DHX58_uc010wgf.1_Silent_p.L226L	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	233					innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGAGCTTCTTCAGCAAGTCCC	0.562													0	0	0	0.007413	0	17	70										T	40260106	C	T	40260106	2	4	6	1	0	0	0	0	0	0	0	1	4514	813	29	1		1	DHX58	17	40260106	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	709762	40260106	40935104	608	1321										
GHDC	84514	broad.mit.edu	37	chr17	40345373	40345373	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aacagtgggggcgctgggctCcctgtagacaccacctcagg	14	13	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:40345373C>T	uc002hzd.2	-	2	711	c.227G>A	c.(226-228)GGA>GAA	p.G76E	GHDC_uc002hzg.1_Missense_Mutation_p.G76E|GHDC_uc010wgg.1_Missense_Mutation_p.G76E|GHDC_uc002hze.3_Missense_Mutation_p.G76E|GHDC_uc002hzf.3_Missense_Mutation_p.G76E|GHDC_uc010cxz.2_RNA	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	76						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		GCGCTGGGCTCCCTGTAGACA	0.647													0	0	0	0.001168	0	4	12										T	40345373	C	T	40345373	3	4	6	1	0	0	0	0	1	0	0	0	6369	855	30	1	1486	1	GHDC	17	40345373	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	85267	40345373	40849837	609	1322										
ATP6V0A1	535	broad.mit.edu	37	chr17	40622219	40622219	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatttatacttcgcaaaactCagcaattttttgatgaggtc	6	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:40622219C>A	uc002hzr.2	+	5	573	c.406C>A	c.(406-408)CAG>AAG	p.Q136K	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.Q136K|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.Q136K|ATP6V0A1_uc010wgj.1_Intron|ATP6V0A1_uc010wgk.1_Intron|ATP6V0A1_uc010cyg.2_Intron|ATP6V0A1_uc010wgl.1_5'UTR|ATP6V0A1_uc002hzp.1_Missense_Mutation_p.Q136K	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	136	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TCGCAAAACTCAGCAATTTTT	0.338													1	0	5.18039e-06	0.00308	5.2655e-06	8	37										A	40622219	C	A	40622219	3	1	6	1	0	0	0	0	1	0	0	0	1168	827	29	3	420	3	ATP6V0A1	17	40622219	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	276846	40622219	40572991	610	1323										
MLX	6945	broad.mit.edu	37	chr17	40722180	40722180	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgtgtgtcttcagctggatCgaggagcactgtaagcctca	13	10	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:40722180C>G	uc002iag.2	+	7	884	c.819C>G	c.(817-819)ATC>ATG	p.I273M	MLX_uc002iaf.2_Missense_Mutation_p.I219M|MLX_uc002iah.2_Missense_Mutation_p.I189M	NM_170607	NP_733752	Q9UH92	MLX_HUMAN	transcription factor-like protein 4 isoform	273					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TCAGCTGGATCGAGGAGCACT	0.532													0	0	0	0.010729	0	11	66										G	40722180	C	G	40722180	3	3	6	1	0	0	0	0	1	0	0	0	9635	874	31	1	845	1	MLX	17	40722180	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	99961	40722180	40473030	611	1324										
ARL4D	379	broad.mit.edu	37	chr17	41477529	41477529	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caggaccagcccggggcactGagcgctgctgaggtggagaa	17	11	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:41477529G>A	uc002idt.2	+	2	610	c.429G>A	c.(427-429)CTG>CTA	p.L143L		NM_001661	NP_001652	P49703	ARL4D_HUMAN	ADP-ribosylation factor-like 4D	143					protein secretion|small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.155)		CCGGGGCACTGAGCGCTGCTG	0.657													0	0	0	0.001168	0	6	11										A	41477529	G	A	41477529	2	1	6	1	0	0	0	0	0	0	0	1	938	1277	45	1		1	ARL4D	17	41477529	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	755349	41477529	39717681	612	1325										
ITGB3	3690	broad.mit.edu	37	chr17	45384893	45384893	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctcagtgatgggggccattCtgctcattggccttgccgcc	12	13	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:45384893C>G	uc002ilj.2	+	14	2211	c.2191C>G	c.(2191-2193)CTG>GTG	p.L731V	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	731	Helical; (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	GGGGGCCATTCTGCTCATTGG	0.547													0	0	0	0.006122	0	18	53										G	45384893	C	G	45384893	3	3	6	1	0	0	0	0	1	0	0	0	7895	912	32	1	2245	1	ITGB3	17	45384893	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3907364	45384893	35810317	613	1326										
SKAP1	8631	broad.mit.edu	37	chr17	46239837	46239837	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctttctgtccttaccttgctCagaatacggatgaggtcacc	8	12	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:46239837C>G	uc002ini.1	-	11	1084	c.972G>C	c.(970-972)CTG>CTC	p.L324L	SKAP1_uc002inj.1_Silent_p.L323L|SKAP1_uc010dbd.1_Silent_p.L229L|SKAP1_uc010dbe.1_Silent_p.L324L	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	324	SH3.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						TTACCTTGCTCAGAATACGGA	0.433													0	0	0	0.006214	0	10	43										G	46239837	C	G	46239837	2	3	6	1	0	0	0	0	0	0	0	1	14355	813	29	1		1	SKAP1	17	46239837	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	854944	46239837	34955373	614	1327										
SFRS1	6426	broad.mit.edu	37	chr17	56083263	56083263	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agtgccatctcggtaaacatCagcataacatacatcacctg	6	12	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:56083263C>G	uc002ivi.2	-	3	660	c.451G>C	c.(451-453)GAT>CAT	p.D151H	SFRS1_uc002ivj.2_Missense_Mutation_p.D151H	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	151	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		CGGTAAACATCAGCATAACAT	0.403													0	0	0	0.006122	0	17	87										G	56083263	C	G	56083263	3	3	6	1	0	0	0	0	1	0	0	0	14165	826	29	1	357	1	SFRS1	17	56083263	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	9843426	56083263	25111947	615	1328										
HEATR6	63897	broad.mit.edu	37	chr17	58156203	58156203	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcgaaacccattgcctcgctCagggattgcttcccgcggtg	12	14	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:58156203C>G	uc002iyk.1	-	1	90	c.73G>C	c.(73-75)GAG>CAG	p.E25Q		NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	25							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TTGCCTCGCTCAGGGATTGCT	0.662													0	0	0	0.000602	0	4	19										G	58156203	C	G	58156203	3	3	6	1	0	0	0	0	1	0	0	0	7033	835	29	1	3552	1	HEATR6	17	58156203	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2072940	58156203	23039007	616	1329										
MED13	9969	broad.mit.edu	37	chr17	60072581	60072581	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atcaggaaaaaggaattcctCatctccttcaacaaatgcat	5	10	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:60072581C>T	uc002izo.2	-	10	2190	c.2113G>A	c.(2113-2115)GAG>AAG	p.E705K		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	705					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AGGAATTCCTCATCTCCTTCA	0.358													0	0	0	0.01441	0	51	118										T	60072581	C	T	60072581	3	4	6	1	0	0	0	0	1	0	0	0	9430	835	29	1	4495	1	MED13	17	60072581	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1916378	60072581	21122629	617	1330										
CCDC47	57003	broad.mit.edu	37	chr17	61842116	61842116	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctacatcaacaatcgttattGggtctttatttttgctagaa	6	7	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:61842116G>A	uc002jbs.3	-	3	692	c.356C>T	c.(355-357)CCA>CTA	p.P119L	CCDC47_uc010ddx.2_Missense_Mutation_p.P119L|CCDC47_uc002jbt.2_Missense_Mutation_p.P119L	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	119						integral to membrane	protein binding				0						AATCGTTATTGGGTCTTTATT	0.338													0	0	0	0.012213	0	32	96										A	61842116	G	A	61842116	3	1	6	1	0	0	0	0	1	0	0	0	2818	1348	47	2	1139	2	CCDC47	17	61842116	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1769535	61842116	19353094	618	1331										
TEX2	55852	broad.mit.edu	37	chr17	62290676	62290676	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttttactaaggagctgaaaaGgctcatagatgacttctgaa	9	6	2	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:62290676G>C	uc002jec.2	-	2	1075	c.902C>G	c.(901-903)CCT>CGT	p.P301R	TEX2_uc002jed.2_Missense_Mutation_p.P301R|TEX2_uc002jee.2_Missense_Mutation_p.P301R	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	301					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GAGCTGAAAAGGCTCATAGAT	0.433													0	0	0	0.012319	0	22	55										C	62290676	G	C	62290676	3	2	6	1	0	0	0	0	1	0	0	0	15778	1000	35	4	2546	4	TEX2	17	62290676	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	448560	62290676	18904534	619	1332										
POLG2	11232	broad.mit.edu	37	chr17	62493011	62493011	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagctccggctgccccgcatCtactcgacccccaaacccag	7	21	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:62493011C>G	uc002jei.2	-	1	159	c.76G>C	c.(76-78)GAT>CAT	p.D26H	POLG2_uc010deg.1_Missense_Mutation_p.D26H	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	26					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			TGCCCCGCATCTACTCGACCC	0.612													0	0	0	0.009718	0	39	109										G	62493011	C	G	62493011	3	3	6	1	0	0	0	0	1	0	0	0	12201	913	32	1	1413	1	POLG2	17	62493011	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	202335	62493011	18702199	620	1333										
SLC16A6	9120	broad.mit.edu	37	chr17	66270075	66270075	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaggaacacttaccagagatGatgccgatggcgacgtacat	12	9	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:66270075G>A	uc002jgz.1	-	3	557	c.369C>T	c.(367-369)ATC>ATT	p.I123I	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Silent_p.I123I	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	123	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	TACCAGAGATGATGCCGATGG	0.483													0	0	0	0.008871	0	17	49										A	66270075	G	A	66270075	2	1	6	1	0	0	0	0	0	0	0	1	14412	1280	45	1		1	SLC16A6	17	66270075	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3777064	66270075	14925135	621	1334										
ABCA8	10351	broad.mit.edu	37	chr17	66914280	66914280	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaggttccatacttggtgtCttgaaaagggatccaatcca	10	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:66914280C>G	uc002jhp.2	-	14	2014	c.1835G>C	c.(1834-1836)AGA>ACA	p.R612T	ABCA8_uc002jhq.2_Missense_Mutation_p.R652T|ABCA8_uc010wqq.1_Missense_Mutation_p.R652T|ABCA8_uc010wqr.1_Missense_Mutation_p.R591T|ABCA8_uc002jhr.2_Missense_Mutation_p.R652T	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	612	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TACTTGGTGTCTTGAAAAGGG	0.458													0	0	0	0.004007	0	16	71										G	66914280	C	G	66914280	3	3	6	1	0	0	0	0	1	0	0	0	38	913	32	1	3010	1	ABCA8	17	66914280	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	644205	66914280	14280930	622	1335										
ABCA10	10349	broad.mit.edu	37	chr17	67187420	67187420	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgctgcttaataagggatgtGattttttctgtgtcacacat	9	6	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:67187420G>C	uc010dfa.1	-	18	2787	c.1908C>G	c.(1906-1908)ATC>ATG	p.I636M	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.I237M	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	636					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TAAGGGATGTGATTTTTTCTG	0.338													0	0	0	0.014323	0	23	68										C	67187420	G	C	67187420	3	2	6	1	0	0	0	0	1	0	0	0	29	1280	45	1	2815	1	ABCA10	17	67187420	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	273140	67187420	14007790	623	1336										
C17orf28	283987	broad.mit.edu	37	chr17	72948414	72948414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accagcacctgcagcagcctCatgatggtctgcagcggcag	12	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:72948414C>T	uc002jmj.3	-	17	2243	c.2094G>A	c.(2092-2094)ATG>ATA	p.M698I	C17orf28_uc002jmi.2_Missense_Mutation_p.M100I|C17orf28_uc010wrs.1_Missense_Mutation_p.M497I	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	698						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					GCAGCAGCCTCATGATGGTCT	0.498													0	0	0	0.00499	0	10	21										T	72948414	C	T	72948414	3	4	6	1	0	0	0	0	1	0	0	0	1853	826	29	1	284	1	C17orf28	17	72948414	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5760994	72948414	8246796	624	1337										
TK1	7083	broad.mit.edu	37	chr17	76171137	76171137	+	Silent	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcaggtggagctacctccttCtctgtgccgagcctcttggt							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:76171137C>T	uc002juw.2	-	6	717	c.507G>A	c.(505-507)GAG>GAA	p.E169E	TK1_uc002jux.2_Silent_p.E211E	NM_003258	NP_003249	P04183	KITH_HUMAN	thymidine kinase 1	169					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			CTACCTCCTTCTCTGTGCCGA	0.662													0	0	0	0.001855	0	12	18										T	76171137	C	T	76171137	2	4	6	1	0	0	0	0	0	0	0	1	15929	912	32	1		1	TK1	17	76171137	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3222723	76171137	5024073	625	1338	9	2								
TK1	7083	broad.mit.edu	37	chr17	76171139	76171139	+	Missense_Mutation	SNP	C	C	T													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggtggagctacctccttctCtgtgccgagcctcttggtat							TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:76171139C>T	uc002juw.2	-	6	715	c.505G>A	c.(505-507)GAG>AAG	p.E169K	TK1_uc002jux.2_Missense_Mutation_p.E211K	NM_003258	NP_003249	P04183	KITH_HUMAN	thymidine kinase 1	169					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			ACCTCCTTCTCTGTGCCGAGC	0.657													0	0	0	0.001855	0	12	18										T	76171139	C	T	76171139	3	4	6	1	0	0	0	0	1	0	0	0	15929	922	32	1	207	1	TK1	17	76171139	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2	76171139	5024071	626	1339	9	2								
RNF213	57674	broad.mit.edu	37	chr17	78353431	78353431	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaccctagtgtggcaggccGatggaacagagcatctgcat	12	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:78353431G>A	uc002jyh.1	+	30	7999	c.7776G>A	c.(7774-7776)CCG>CCA	p.P2592P	uc002jyi.1_Intron|RNF213_uc010dhw.1_Silent_p.P974P	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTGGCAGGCCGATGGAACAGA	0.502													0	0	0	0.00623	0	26	93										A	78353431	G	A	78353431	2	1	6	1	0	0	0	0	0	0	0	1	13477	1045	37	1		1	RNF213	17	78353431	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2182292	78353431	2841779	627	1340										
SLC38A10	124565	broad.mit.edu	37	chr17	79226054	79226054	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cggcgttgcctggcggcggtCcccccttggccttttcccct	12	18	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:79226054C>A	uc002jzz.1	-	13	2261	c.1886G>T	c.(1885-1887)GGA>GTA	p.G629V	SLC38A10_uc002jzy.1_Missense_Mutation_p.G547V|SLC38A10_uc002kab.2_Missense_Mutation_p.G629V	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	629					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TGGCGGCGGTCCCCCCTTGGC	0.711													1	0	7.45023e-12	0.010504	7.66498e-12	20	64										A	79226054	C	A	79226054	3	1	6	1	0	0	0	0	1	0	0	0	14602	855	30	3	1767	3	SLC38A10	17	79226054	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	872623	79226054	1969156	628	1341										
RAB40B	10966	broad.mit.edu	37	chr17	80616472	80616472	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	attgcacagagggctgacctCaaagaaggtcacgcccaggc	12	12	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr17:80616472C>G	uc002kft.2	-	5	586	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	RAB40B_uc002kfs.2_RNA	NM_006822	NP_006813	Q12829	RB40B_HUMAN	RAB40B, member RAS oncogene family	154					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			central_nervous_system(1)	1	Breast(20;0.00132)|all_neural(118;0.0952)	all_cancers(8;0.072)|all_epithelial(8;0.139)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GGGCTGACCTCAAAGAAGGTC	0.652													0	0	0	0.003271	0	34	82										G	80616472	C	G	80616472	3	3	6	1	0	0	0	0	1	0	0	0	12941	835	29	1	384	1	RAB40B	17	80616472	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1390418	80616472	578738	629	1342										
METTL4	64863	broad.mit.edu	37	chr18	2547371	2547371	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacttttacccagtgccactCagcaactacctccacagacc	4	17	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:2547371C>G	uc002klh.3	-	6	1837	c.1057G>C	c.(1057-1059)GAG>CAG	p.E353Q	METTL4_uc010dkj.2_Missense_Mutation_p.E150Q	NM_022840	NP_073751	Q8N3J2	METL4_HUMAN	methyltransferase like 4	353					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			kidney(1)|skin(1)	2						CAGTGCCACTCAGCAACTACC	0.388													0	0	0	0.013726	0	34	93										G	2547371	C	G	2547371	3	3	6	1	0	0	0	0	1	0	0	0	9502	835	29	1	377	1	METTL4	18	2547371	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		2547371	75529877	630	1343										
EMILIN2	84034	broad.mit.edu	37	chr18	2892354	2892354	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgtggaactgtgtcaggcaGatgaacggaacgctcaggtc	14	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:2892354G>A	uc002kln.2	+	4	2388	c.2229G>A	c.(2227-2229)CAG>CAA	p.Q743Q		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	743					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		GTGTCAGGCAGATGAACGGAA	0.493													0	0	0	0.008871	0	20	61										A	2892354	G	A	2892354	2	1	6	1	0	0	0	0	0	0	0	1	5094	933	33	1		1	EMILIN2	18	2892354	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	344983	2892354	75184894	631	1344										
DLGAP1	9229	broad.mit.edu	37	chr18	3508616	3508616	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggtagaatttctgggccatGagaagttgggcactgcccac	13	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:3508616G>C	uc002kmf.2	-	8	2590	c.2523C>G	c.(2521-2523)CTC>CTG	p.L841L	DLGAP1_uc010wyz.1_Silent_p.L841L|DLGAP1_uc002kme.1_Silent_p.L539L|DLGAP1_uc010dkn.2_Silent_p.L549L|DLGAP1_uc010wyw.1_Silent_p.L547L|DLGAP1_uc010wyx.1_Silent_p.L563L|DLGAP1_uc010wyy.1_Silent_p.L525L|DLGAP1_uc002kmg.2_Silent_p.L539L	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	841					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				TCTGGGCCATGAGAAGTTGGG	0.433													0	0	0	0.006122	0	15	60										C	3508616	G	C	3508616	2	2	6	1	0	0	0	0	0	0	0	1	4559	1277	45	1		1	DLGAP1	18	3508616	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	616262	3508616	74568632	632	1345										
LAMA1	284217	broad.mit.edu	37	chr18	7023260	7023260	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cccaggcacttcaggcactcCccggtgactgagtcacagtg	11	15	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:7023260C>T	uc002knm.2	-	19	2698	c.2604G>A	c.(2602-2604)GGG>GGA	p.G868G	LAMA1_uc010wzj.1_Silent_p.G344G	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	868	Laminin EGF-like 8.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAGGCACTCCCCGGTGACTG	0.602													0	0	0	0.013537	0	13	47										T	7023260	C	T	7023260	2	4	6	1	0	0	0	0	0	0	0	1	8605	610	22	2		2	LAMA1	18	7023260	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3514644	7023260	71053988	633	1346										
ANKRD12	23253	broad.mit.edu	37	chr18	9255144	9255144	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caaatgccaaaataaaggatGaagatcatagtccaacattt	6	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:9255144G>A	uc002knv.2	+	9	2136	c.1879G>A	c.(1879-1881)GAA>AAA	p.E627K	ANKRD12_uc002knw.2_Missense_Mutation_p.E604K|ANKRD12_uc002knx.2_Missense_Mutation_p.E604K|ANKRD12_uc010dkx.1_Missense_Mutation_p.E334K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	627						nucleus				ovary(2)|central_nervous_system(1)	3						AATAAAGGATGAAGATCATAG	0.184													0	0	0	0.00632	0	30	88										A	9255144	G	A	9255144	3	1	6	1	0	0	0	0	1	0	0	0	640	1291	45	1	1909	1	ANKRD12	18	9255144	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2231884	9255144	68822104	634	1347										
ROCK1	6093	broad.mit.edu	37	chr18	18549123	18549123	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttagctcttcattctctcttCttaatatttcaatatctttg	2	9	7	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:18549123C>G	uc002kte.2	-	24	3808	c.2867G>C	c.(2866-2868)AGA>ACA	p.R956T		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	956	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					ATTCTCTCTTCTTAATATTTC	0.323													0	0	0	0.008871	0	19	49										G	18549123	C	G	18549123	3	3	6	1	0	0	0	0	1	0	0	0	13517	913	32	1	1237	1	ROCK1	18	18549123	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	9293979	18549123	59528125	635	1348										
MEP1B	4225	broad.mit.edu	37	chr18	29795197	29795197	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagattttataaaaggagatGatgtttatatcctactgaca	8	4	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:29795197G>A	uc002kxj.3	+	12	1779	c.1732G>A	c.(1732-1734)GAT>AAT	p.D578N		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	578	Extracellular (Potential).|MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						AAAAGGAGATGATGTTTATAT	0.348													0	0	0	0.004672	0	3	40										A	29795197	G	A	29795197	3	1	6	1	0	0	0	0	1	0	0	0	9476	1290	45	1	1778	1	MEP1B	18	29795197	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	11246074	29795197	48282051	636	1349										
NOL4	8715	broad.mit.edu	37	chr18	31709969	31709969	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcgtaaagatagcttctcatCtacccctacgccatcctgga	6	14	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:31709969C>G	uc010dmi.2	-	2	509	c.280G>C	c.(280-282)GAT>CAT	p.D94H	NOL4_uc002kxr.3_5'UTR|NOL4_uc010xbt.1_Missense_Mutation_p.D20H|NOL4_uc010dmh.2_Missense_Mutation_p.D20H|NOL4_uc010xbu.1_Missense_Mutation_p.D94H|NOL4_uc002kxt.3_Missense_Mutation_p.D94H|NOL4_uc010xbw.1_5'UTR	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	94						nucleolus	RNA binding			ovary(3)	3						AGCTTCTCATCTACCCCTACG	0.353													0	0	0	0.007413	0	18	56										G	31709969	C	G	31709969	3	3	6	1	0	0	0	0	1	0	0	0	10524	913	32	1	1676	1	NOL4	18	31709969	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1914772	31709969	46367279	637	1350										
ZNF397OS	100101467	broad.mit.edu	37	chr18	32833853	32833853	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtttttcaccactatgaattCtctgatgtctaacaaggtct	6	9	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:32833853C>T	uc002kym.2	-	4	1274	c.1046G>A	c.(1045-1047)AGA>AAA	p.R349K	ZNF397_uc010dmq.2_Intron|ZNF397_uc010dmr.2_Intron|ZNF397_uc002kyj.2_Intron|ZNF397OS_uc002kyl.2_5'Flank|ZNF397OS_uc010xce.1_Missense_Mutation_p.R349K	NM_001112734	NP_001106205	Q86W11	ZSC30_HUMAN	zinc finger protein 397 opposite strand	349	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACTATGAATTCTCTGATGTCT	0.438													0	0	0	0.013726	0	33	138										T	32833853	C	T	32833853	3	4	6	1	0	0	0	0	1	0	0	0	17881	913	32	1	442	1	ZNF397OS	18	32833853	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1123884	32833853	45243395	638	1351										
ATP5A1	498	broad.mit.edu	37	chr18	43669842	43669842	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tacacgacccaacagctcctCaccaactggaacgtccacaa	5	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:43669842C>T	uc002lbr.1	-	4	520	c.430G>A	c.(430-432)GAG>AAG	p.E144K	ATP5A1_uc010dnl.1_Missense_Mutation_p.E94K|ATP5A1_uc002lbs.1_Missense_Mutation_p.E94K|ATP5A1_uc002lbt.1_Missense_Mutation_p.E144K|ATP5A1_uc010xct.1_Missense_Mutation_p.E94K|ATP5A1_uc010dnm.1_RNA	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	144					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						AACAGCTCCTCACCAACTGGA	0.418													0	0	0	0.008871	0	19	78										T	43669842	C	T	43669842	3	4	6	1	0	0	0	0	1	0	0	0	1147	835	29	1	1267	1	ATP5A1	18	43669842	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	10835989	43669842	34407406	639	1352										
SMAD2	4087	broad.mit.edu	37	chr18	45368266	45368266	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tactttgtccaaccactgtaGaggtccattcagatgaagtt	8	9	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:45368266G>C	uc002lcy.2	-	11	1584	c.1336C>G	c.(1336-1338)CTA>GTA	p.L446V	SMAD2_uc002lcz.2_Missense_Mutation_p.L446V|SMAD2_uc010xdc.1_Missense_Mutation_p.L416V	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	446	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						AACCACTGTAGAGGTCCATTC	0.408													0	0	0	0.008871	0	20	72										C	45368266	G	C	45368266	3	2	6	1	0	0	0	0	1	0	0	0	14758	933	33	1	71	1	SMAD2	18	45368266	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1698424	45368266	32708982	640	1353										
SMAD4	4089	broad.mit.edu	37	chr18	48591846	48591846	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aaatggatgttcaggtaggaGagacatttaaggttccttca	11	5	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr18:48591846G>A	uc010xdp.1	+	9	1547	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	SMAD4_uc002lfb.3_Missense_Mutation_p.E182K	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	337	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)|p.E337E(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TCAGGTAGGAGAGACATTTAA	0.418									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.01441	0	45	121										A	48591846	G	A	48591846	3	1	6	1	0	0	0	0	1	0	0	0	14760	943	33	1	1039	1	SMAD4	18	48591846	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3223580	48591846	29485402	641	1354										
PRTN3	5657	broad.mit.edu	37	chr19	847830	847830	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggccccctgatctgtgatgGcatcatccaaggaatagact	10	11	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:847830G>A	uc002lqa.1	+	5	656	c.632G>A	c.(631-633)GGC>GAC	p.G211D		NM_002777	NP_002768	P24158	PRTN3_HUMAN	myeloblastin	211	Peptidase S1.				collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTGTGATGGCATCATCCAA	0.612													0	0	0	0.009096	0	3	30										A	847830	G	A	847830	3	1	6	1	0	0	0	0	1	0	0	0	12639	1203	42	2	650	2	PRTN3	19	847830	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		847830	58281153	642	1355										
SBNO2	22904	broad.mit.edu	37	chr19	1111584	1111584	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtctggctcaggatggtggtGaggacacagtgcagggcccg	18	9	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:1111584G>A	uc002lrk.3	-	24	2968	c.2730C>T	c.(2728-2730)CTC>CTT	p.L910L	SBNO2_uc002lri.3_5'Flank|SBNO2_uc002lrj.3_Silent_p.L853L|SBNO2_uc010dse.2_Silent_p.L893L|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	910					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGATGGTGGTGAGGACACAGT	0.662													0	0	0	0.004672	0	3	9										A	1111584	G	A	1111584	2	1	6	1	0	0	0	0	0	0	0	1	13863	1277	45	1		1	SBNO2	19	1111584	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	263754	1111584	58017399	643	1356										
AP3D1	8943	broad.mit.edu	37	chr19	2116613	2116613	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagcagctcacccgagccagCtcttcctcgtccgcctccga	8	20	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:2116613C>T	uc002luz.2	-	17	2215	c.1992G>A	c.(1990-1992)GAG>GAA	p.E664E	AP3D1_uc002luy.2_Silent_p.E573E|AP3D1_uc002lva.2_Silent_p.E664E	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	664	Potential.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGAGCCAGCTCTTCCTCGT	0.692													0	0	0	0.001168	0	4	9										T	2116613	C	T	2116613	2	4	6	1	0	0	0	0	0	0	0	1	746	796	28	2		2	AP3D1	19	2116613	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1005029	2116613	57012370	644	1357										
MCOLN1	57192	broad.mit.edu	37	chr19	7591755	7591755	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctgccagcggtactaccacCgaggccacgtggacccggcc	12	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:7591755C>T	uc002mgo.2	+	4	639	c.514C>T	c.(514-516)CGA>TGA	p.R172*	MCOLN1_uc002mgp.2_Silent_p.T58T	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	172				ALCQRYYHRGHVDPANDTFDIDPMVVTD -> LSASGTTTE ATWTRPTTHLTLIRWWLLVN (in Ref. 3; AAG42242).	calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GTACTACCACCGAGGCCACGT	0.607													0	0	0	0.005443	0	24	99										T	7591755	C	T	7591755	4	4	6	1	0	0	0	0	0	1	0	0	9395	644	23	2	528	2	MCOLN1	19	7591755	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5475142	7591755	51537228	645	1358										
TIMM44	10469	broad.mit.edu	37	chr19	8000015	8000015	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctcgctcgtccgcacggtttCtgactcgatggttttctagg	11	12	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:8000015C>G	uc002miz.2	-	4	330	c.328G>C	c.(328-330)GAA>CAA	p.E110Q	TIMM44_uc002mja.2_5'UTR|TIMM44_uc010dvx.1_RNA	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	110					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CGCACGGTTTCTGACTCGATG	0.423													0	0	0	0.00308	0	8	17										G	8000015	C	G	8000015	3	3	6	1	0	0	0	0	1	0	0	0	15909	922	32	1	1070	1	TIMM44	19	8000015	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	408260	8000015	51128968	646	1359										
MARCH2	51257	broad.mit.edu	37	chr19	8503337	8503337	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accaaccagaaagttcgcctGaagatccgggaggcggacag	13	11	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:8503337G>A	uc002mjv.2	+	6	1089	c.648G>A	c.(646-648)CTG>CTA	p.L216L	MARCH2_uc002mjw.2_Silent_p.L216L|MARCH2_uc002mjx.2_Silent_p.L146L	NM_016496	NP_057580	Q9P0N8	MARH2_HUMAN	membrane-associated ring finger (C3HC4) 2	216					endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AAGTTCGCCTGAAGATCCGGG	0.617													0	0	0	0.007291	0	30	75										A	8503337	G	A	8503337	2	1	6	1	0	0	0	0	0	0	0	1	9301	1277	45	1		1	MARCH2	19	8503337	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	503322	8503337	50625646	647	1360										
MUC16	94025	broad.mit.edu	37	chr19	8999056	8999056	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcacagagctccgctgtgtGaaacctgcatagagagggag	15	9	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:8999056G>A	uc002mkp.2	-	57	40992	c.40788C>T	c.(40786-40788)TTC>TTT	p.F13596F	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.F413F|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13598	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCGCTGTGTGAAACCTGCAT	0.537													0	0	0	0.001168	0	6	20										A	8999056	G	A	8999056	2	1	6	1	0	0	0	0	0	0	0	1	9973	1281	45	1		1	MUC16	19	8999056	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	495719	8999056	50129927	648	1361										
ZNF562	54811	broad.mit.edu	37	chr19	9767306	9767306	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctaggttgtatttcccattCtgaagttaagcagaaaaaga	8	6	2	3	rs140829241		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:9767306C>T	uc010xks.1	-	5	428	c.265G>A	c.(265-267)GAA>AAA	p.E89K	ZNF562_uc002mly.2_Missense_Mutation_p.E89K|ZNF562_uc002mlx.2_Missense_Mutation_p.E17K|ZNF562_uc010xkt.1_Missense_Mutation_p.E52K|ZNF562_uc010xku.1_Missense_Mutation_p.E20K|ZNF562_uc010xkv.1_Missense_Mutation_p.E89K|ZNF562_uc010xkw.1_5'UTR	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	89	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTCCCATTCTGAAGTTAAG	0.328													0	0	0	0.010771	0	44	120										T	9767306	C	T	9767306	3	4	6	1	0	0	0	0	1	0	0	0	17990	922	32	1	1023	1	ZNF562	19	9767306	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	768250	9767306	49361677	649	1362										
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10221062	10221062	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcgtcggggagggcaaagtGatgttccacagttttggtga	17	6	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:10221062G>A	uc002mna.2	+	9	885	c.885G>A	c.(883-885)GTG>GTA	p.V295V	PPAN-P2RY11_uc010xla.1_Silent_p.V295V|P2RY11_uc002mnc.2_5'Flank|PPAN_uc002mmz.1_Silent_p.V295V|PPAN_uc002mnb.1_Silent_p.V242V	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	295					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			AGGGCAAAGTGATGTTCCACA	0.657													0	0	0	0.003163	0	14	31										A	10221062	G	A	10221062	2	1	6	1	0	0	0	0	0	0	0	1	12289	1277	45	1		1	PPAN-P2RY11	19	10221062	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	453756	10221062	48907921	650	1363										
ATG4D	84971	broad.mit.edu	37	chr19	10657634	10657634	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgggcccagggtgcccctGagctggagcaggaacgccgg	18	13	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:10657634G>A	uc002mov.2	+	4	733	c.613G>A	c.(613-615)GAG>AAG	p.E205K	ATG4D_uc010xlg.1_Missense_Mutation_p.E228K|ATG4D_uc010xlh.1_Missense_Mutation_p.E142K|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_Intron|ATG4D_uc010dxj.2_Intron	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	205					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GGGTGCCCCTGAGCTGGAGCA	0.716													0	0	0	0.004482	0	9	15										A	10657634	G	A	10657634	3	1	6	1	0	0	0	0	1	0	0	0	1099	1291	45	1	627	1	ATG4D	19	10657634	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	436572	10657634	48471349	651	1364										
ATG4D	84971	broad.mit.edu	37	chr19	10663639	10663639	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atgctcaggaccacagcctgGacgacctctgctcccagctc	9	17	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:10663639G>T	uc002mov.2	+	10	1441	c.1321G>T	c.(1321-1323)GAC>TAC	p.D441Y	ATG4D_uc010xlh.1_Missense_Mutation_p.D378Y|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Missense_Mutation_p.D108Y	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	441					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCACAGCCTGGACGACCTCTG	0.657													1	0	1.43246e-33	0.007835	1.49868e-33	34	96										T	10663639	G	T	10663639	3	4	6	1	0	0	0	0	1	0	0	0	1099	1174	41	3	1359	3	ATG4D	19	10663639	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	6005	10663639	48465344	652	1365										
AP1M2	10053	broad.mit.edu	37	chr19	10692042	10692042	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atggtaccgacgatttcgctCagaaggacgctgccgttggc	13	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:10692042C>T	uc002mpc.2	-	6	657	c.573G>A	c.(571-573)CTG>CTA	p.L191L	AP1M2_uc002mpd.2_Silent_p.L191L	NM_005498	NP_005489	Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	191	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CGATTTCGCTCAGAAGGACGC	0.592											OREG0025241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	14	30										T	10692042	C	T	10692042	2	4	6	1	0	0	0	0	0	0	0	1	735	813	29	1		1	AP1M2	19	10692042	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	28403	10692042	48436941	653	1366										
FBXW9	84261	broad.mit.edu	37	chr19	12805444	12805444	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cgcttagtgcctaaggtcttGatcagaacctggttggactc	11	10	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:12805444G>C	uc010dyx.2	-	3	612	c.612C>G	c.(610-612)ATC>ATG	p.I204M	FBXW9_uc010xmp.1_RNA|FBXW9_uc002mum.1_Missense_Mutation_p.I214M|FBXW9_uc002mun.1_Missense_Mutation_p.I51M	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	214							protein binding			ovary(1)	1						CTAAGGTCTTGATCAGAACCT	0.498													0	0	0	0.001984	0	5	52										C	12805444	G	C	12805444	3	2	6	1	0	0	0	0	1	0	0	0	5771	1280	45	1	766	1	FBXW9	19	12805444	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2113402	12805444	46323539	654	1367										
CACNA1A	773	broad.mit.edu	37	chr19	13409682	13409682	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggggtccccggccttgcctCgctcggcctcgccctcccag	13	20	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:13409682C>T	uc010dze.2	-	19	3004	c.2768G>A	c.(2767-2769)CGA>CAA	p.R923Q	CACNA1A_uc010dzc.2_Missense_Mutation_p.R448Q|CACNA1A_uc002mwy.3_Missense_Mutation_p.R922Q|CACNA1A_uc010xne.1_Missense_Mutation_p.R451Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	923	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding	p.R923Q(1)		large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGCCTTGCCTCGCTCGGCCTC	0.776													0	0	0	0.001984	0	6	21										T	13409682	C	T	13409682	3	4	6	1	0	0	0	0	1	0	0	0	2538	884	31	1	4973	1	CACNA1A	19	13409682	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	604238	13409682	45719301	655	1368										
LPHN1	22859	broad.mit.edu	37	chr19	14269281	14269281	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agggccacccgggcctgcttCgccggccagcttcactgtgg	14	16	1	0	rs146726289		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:14269281C>T	uc010xnn.1	-	13	2544	c.2248G>A	c.(2248-2250)GAA>AAA	p.E750K	LPHN1_uc010xno.1_Missense_Mutation_p.E745K|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	750	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						GGGCCTGCTTCGCCGGCCAGC	0.597													0	0	0	0.003163	0	16	45										T	14269281	C	T	14269281	3	4	6	1	0	0	0	0	1	0	0	0	8915	893	31	1	2224	1	LPHN1	19	14269281	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	859599	14269281	44859702	656	1369										
OR7A5	26659	broad.mit.edu	37	chr19	14938601	14938601	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcaaggaatacagagcactCatggtccaggatgctagaac	11	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:14938601C>G	uc002mzw.2	-	1	676	c.453G>C	c.(451-453)ATG>ATC	p.M151I	OR7A5_uc010xoa.1_Missense_Mutation_p.M151I	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						ACAGAGCACTCATGGTCCAGG	0.488													0	0	0	0.012319	0	23	55										G	14938601	C	G	14938601	3	3	6	1	0	0	0	0	1	0	0	0	11216	826	29	1	510	1	OR7A5	19	14938601	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	669320	14938601	44190382	657	1370										
C19orf44	84167	broad.mit.edu	37	chr19	16611956	16611956	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaatttgtctgacacggaatCtgactcaatgaccgccgatg	10	10	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:16611956C>G	uc002neh.1	+	2	426	c.353C>G	c.(352-354)TCT>TGT	p.S118C	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.S118C|C19orf44_uc002neg.2_Missense_Mutation_p.S118C|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	118											0						GACACGGAATCTGACTCAATG	0.552													0	0	0	0.010771	0	44	97										G	16611956	C	G	16611956	3	3	6	1	0	0	0	0	1	0	0	0	1927	913	32	1	355	1	C19orf44	19	16611956	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1673355	16611956	42517027	658	1371										
F2RL3	9002	broad.mit.edu	37	chr19	17000940	17000940	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagaccttccggctggcgcgCtccgatcgcgtgctctgcca	12	17	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:17000940C>T	uc002nfa.2	+	2	841	c.666C>T	c.(664-666)CGC>CGT	p.R222R		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	222	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						GGCTGGCGCGCTCCGATCGCG	0.706													0	0	0	0.004482	0	8	18										T	17000940	C	T	17000940	2	4	6	1	0	0	0	0	0	0	0	1	5346	784	28	2		2	F2RL3	19	17000940	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	388984	17000940	42128043	659	1372										
MPV17L2	84769	broad.mit.edu	37	chr19	18305832	18305832	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttcgtgcccccccaatttcGagtcacctacatcaacggcc	6	18	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:18305832G>C	uc002nid.2	+	4	552	c.500G>C	c.(499-501)CGA>CCA	p.R167P	MPV17L2_uc010ebj.2_Silent_p.S77S	NM_032683	NP_116072	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	167						integral to membrane					0						CCCCAATTTCGAGTCACCTAC	0.502													0	0	0	0.012213	0	26	96										C	18305832	G	C	18305832	3	2	6	1	0	0	0	0	1	0	0	0	9747	1058	37	1	514	1	MPV17L2	19	18305832	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1304892	18305832	40823151	660	1373										
CILP2	148113	broad.mit.edu	37	chr19	19651906	19651906	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctgccttccgcagaagcctCgtggggcgcgtggggcccgt	16	15	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:19651906C>G	uc002nmv.3	+	4	528	c.443C>G	c.(442-444)TCG>TGG	p.S148W	CILP2_uc002nmw.3_Missense_Mutation_p.S154W	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	148	TSP type-1.					proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GCAGAAGCCTCGTGGGGCGCG	0.716													0	0	0	0.000602	0	5	3										G	19651906	C	G	19651906	3	3	6	1	0	0	0	0	1	0	0	0	3430	893	31	1	457	1	CILP2	19	19651906	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1346074	19651906	39477077	661	1374										
ZNF507	22847	broad.mit.edu	37	chr19	32844356	32844356	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgtcggaaaaccacagaaaGaaatgaaaccattccagata	8	8	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:32844356G>T	uc002nte.2	+	3	892	c.620G>T	c.(619-621)AGA>ATA	p.R207I	ZNF507_uc002ntc.2_Missense_Mutation_p.R207I|ZNF507_uc010xrn.1_Missense_Mutation_p.R207I|ZNF507_uc002ntd.2_Missense_Mutation_p.R207I	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					ACCACAGAAAGAAATGAAACC	0.458													1	0	3.5997e-14	0.014323	3.71169e-14	24	64										T	32844356	G	T	32844356	3	4	6	1	0	0	0	0	1	0	0	0	17950	942	33	3	622	3	ZNF507	19	32844356	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	13192450	32844356	26284627	662	1375										
KIRREL2	84063	broad.mit.edu	37	chr19	36349402	36349402	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagaggatgaagcatcatatGaatgtcaggctacacaagca	10	7	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:36349402G>A	uc002ocb.3	+	3	516	c.304G>A	c.(304-306)GAA>AAA	p.E102K	KIRREL2_uc002obz.3_Missense_Mutation_p.E102K|KIRREL2_uc002oca.3_Missense_Mutation_p.E52K|KIRREL2_uc002occ.3_Missense_Mutation_p.E49K|KIRREL2_uc002ocd.3_Missense_Mutation_p.E99K	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	102	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCATCATATGAATGTCAGGC	0.592													0	0	0	0.008871	0	20	98										A	36349402	G	A	36349402	3	1	6	1	0	0	0	0	1	0	0	0	8325	1291	45	1	314	1	KIRREL2	19	36349402	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3505046	36349402	22779581	663	1376										
KIRREL2	84063	broad.mit.edu	37	chr19	36349660	36349660	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctctgtgtctctggttgctgGagttcctgcgaacctgacat	11	11	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:36349660G>C	uc002ocb.3	+	4	628	c.416G>C	c.(415-417)GGA>GCA	p.G139A	KIRREL2_uc002obz.3_Missense_Mutation_p.G139A|KIRREL2_uc002oca.3_Missense_Mutation_p.G89A|KIRREL2_uc002occ.3_Missense_Mutation_p.G86A|KIRREL2_uc002ocd.3_Missense_Mutation_p.G136A	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	139	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGGTTGCTGGAGTTCCTGCG	0.617													0	0	0	0.004289	0	34	118										C	36349660	G	C	36349660	3	2	6	1	0	0	0	0	1	0	0	0	8325	1174	41	1	430	1	KIRREL2	19	36349660	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	258	36349660	22779323	664	1377										
ZNF461	92283	broad.mit.edu	37	chr19	37130933	37130933	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ataacttctggggctcatctCtggatgccaagtctgaaaga	10	9	4	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:37130933C>G	uc002oem.2	-	6	542	c.314G>C	c.(313-315)AGA>ACA	p.R105T	ZNF461_uc002oen.2_Missense_Mutation_p.R74T|ZNF461_uc010xtj.1_Missense_Mutation_p.R82T	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GGGCTCATCTCTGGATGCCAA	0.343													0	0	0	0.014323	0	23	83										G	37130933	C	G	37130933	3	3	6	1	0	0	0	0	1	0	0	0	17922	913	32	1	1381	1	ZNF461	19	37130933	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	781273	37130933	21998050	665	1378										
GGN	199720	broad.mit.edu	37	chr19	38877342	38877342	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggccagagcaggagtgattCtgcggtccgccggctgccgt	16	12	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:38877342C>T	uc002oij.1	-	3	695	c.560G>A	c.(559-561)AGA>AAA	p.R187K	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Missense_Mutation_p.R104K	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	187	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGGAGTGATTCTGCGGTCCGC	0.692													0	0	0	0.000602	0	4	7										T	38877342	C	T	38877342	3	4	6	1	0	0	0	0	1	0	0	0	6358	913	32	1	1406	1	GGN	19	38877342	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1746409	38877342	20251641	666	1379										
RYR1	6261	broad.mit.edu	37	chr19	39008108	39008108	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaggtgcccgctacacagaGatgccgcatgtcatcgagat	11	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:39008108G>A	uc002oit.2	+	66	9925	c.9795G>A	c.(9793-9795)GAG>GAA	p.E3265E	RYR1_uc002oiu.2_Silent_p.E3265E|RYR1_uc002oiv.1_Silent_p.E185E|RYR1_uc010xuf.1_Silent_p.E185E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3265					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTACACAGAGATGCCGCATG	0.672													0	0	0	0.004007	0	16	45										A	39008108	G	A	39008108	2	1	6	1	0	0	0	0	0	0	0	1	13768	933	33	1		1	RYR1	19	39008108	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	130766	39008108	20120875	667	1380										
RYR1	6261	broad.mit.edu	37	chr19	39061261	39061261	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctcagaactacctgtcccgGaacttttacaccctgcggtt	7	14	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:39061261G>A	uc002oit.2	+	94	13804	c.13674G>A	c.(13672-13674)CGG>CGA	p.R4558R	RYR1_uc002oiu.2_Silent_p.R4553R	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4558			R -> Q (in CCD; autosomal recessive form).		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACCTGTCCCGGAACTTTTACA	0.483													0	0	0	0.009718	0	39	144										A	39061261	G	A	39061261	2	1	6	1	0	0	0	0	0	0	0	1	13768	1161	41	1		1	RYR1	19	39061261	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	53153	39061261	20067722	668	1381										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41770632	41770632	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gggctccgagctggaggggaCcgcgcagccaccgccgcccg	17	17	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:41770632C>T	uc002oqb.3	+	1	513	c.224C>T	c.(223-225)ACC>ATC	p.T75I	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Intron|HNRNPUL1_uc002oqa.3_Intron|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.T75I|HNRNPUL1_uc002oqc.3_Intron|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Intron|HNRNPUL1_uc010ehn.2_5'Flank|HNRNPUL1_uc010eho.2_5'Flank|HNRNPUL1_uc010xvy.1_5'Flank|HNRNPUL1_uc010ehl.1_Intron	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	75	Necessary for interaction with HRMT1L1.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CTGGAGGGGACCGCGCAGCCA	0.766													0	0	0	0.000602	0	4	3										T	41770632	C	T	41770632	3	4	6	1	0	0	0	0	1	0	0	0	7274	507	18	2	226	2	HNRNPUL1	19	41770632	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2709371	41770632	17358351	669	1382										
EXOSC5	56915	broad.mit.edu	37	chr19	41892596	41892596	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaaacggaagacgtgttgcGaagcggcctgggccgcagcc	16	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:41892596G>C	uc002oqo.2	-	6	673	c.650C>G	c.(649-651)TCG>TGG	p.S217W	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Intron	NM_020158	NP_064543	Q9NQT4	EXOS5_HUMAN	exosome component Rrp46	217					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|protein binding|RNA binding				0						GACGTGTTGCGAAGCGGCCTG	0.662													0	0	0	0.000602	0	5	9										C	41892596	G	C	41892596	3	2	6	1	0	0	0	0	1	0	0	0	5318	1059	37	1	61	1	EXOSC5	19	41892596	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	121964	41892596	17236387	670	1383										
PSG3	5671	broad.mit.edu	37	chr19	43233301	43233301	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctttgactgtcatggatttgGagctttccatgccagtggct	11	9	1	1	rs141177217	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:43233301G>C	uc002oue.2	-	5	1349	c.1217C>G	c.(1216-1218)TCC>TGC	p.S406C	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Missense_Mutation_p.S406C|PSG3_uc010eil.2_Missense_Mutation_p.S428C	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	406	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				CATGGATTTGGAGCTTTCCAT	0.473													0	0	0	0.01441	0	67	259										C	43233301	G	C	43233301	3	2	6	1	0	0	0	0	1	0	0	0	12656	1174	41	1	77	1	PSG3	19	43233301	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1340705	43233301	15895682	671	1384										
LYPD5	284348	broad.mit.edu	37	chr19	44301925	44301925	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccaggggctggtggtgccctCggtggtgcaggagggccggt	21	10	0	0	rs114185213	by1000genomes	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:44301925C>T	uc002oxm.3	-	5	655	c.574G>A	c.(574-576)GAG>AAG	p.E192K	LYPD5_uc002oxn.3_Missense_Mutation_p.E149K	NM_001031749	NP_001026919	Q6UWN5	LYPD5_HUMAN	LY6/PLAUR domain containing 5 isoform A	192	UPAR/Ly6.					anchored to membrane|plasma membrane					0		Prostate(69;0.0352)				GTGGTGCCCTCGGTGGTGCAG	0.612													0	0	0	0.008291	0	11	57										T	44301925	C	T	44301925	3	4	6	1	0	0	0	0	1	0	0	0	9113	893	31	1	185	1	LYPD5	19	44301925	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1068624	44301925	14827058	672	1385										
ZNF222	7673	broad.mit.edu	37	chr19	44537161	44537161	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaatctggatataattttatCattatttttaaatgacatat	4	3	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:44537161C>G	uc002oyc.2	+	4	1517	c.1334C>G	c.(1333-1335)TCA>TGA	p.S445*	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Nonsense_Mutation_p.S485*|ZNF222_uc002oyd.2_Nonsense_Mutation_p.S391*	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				ATAATTTTATCAttattttta	0.219													0	0	0	0.001168	0	6	31										G	44537161	C	G	44537161	4	3	6	1	0	0	0	0	0	1	0	0	17773	838	29	1	1487	1	ZNF222	19	44537161	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	235236	44537161	14591822	673	1386										
ZNF227	7770	broad.mit.edu	37	chr19	44739461	44739461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcatcagagaattcacccagGagagaaactcaatagatgtc	8	9	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:44739461G>A	uc002oyu.2	+	6	1083	c.878G>A	c.(877-879)GGA>GAA	p.G293E	ZNF227_uc010xwu.1_Missense_Mutation_p.G242E|ZNF227_uc002oyv.2_Missense_Mutation_p.G293E|ZNF227_uc010xwv.1_Missense_Mutation_p.G242E|ZNF227_uc010xww.1_Missense_Mutation_p.G214E|ZNF227_uc002oyw.2_Missense_Mutation_p.G265E|ZNF227_uc010ejh.2_Missense_Mutation_p.G286E|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				ATTCACCCAGGAGAGAAACTC	0.398													0	0	0	0.00499	0	18	43										A	44739461	G	A	44739461	3	1	6	1	0	0	0	0	1	0	0	0	17778	1174	41	1	892	1	ZNF227	19	44739461	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	202300	44739461	14389522	674	1387										
NKPD1	284353	broad.mit.edu	37	chr19	45655522	45655522	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaggggaagtcggcgcccaGgaagcgctcgaagagctcgg	18	10	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:45655522G>A	uc010xxi.1	-	4	2173	c.2173C>T	c.(2173-2175)CTG>TTG	p.L725L		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		TCGGCGCCCAGGAAGCGCTCG	0.672													0	0	0	0.001168	0	5	11										A	45655522	G	A	45655522	2	1	6	1	0	0	0	0	0	0	0	1	10446	991	35	2		2	NKPD1	19	45655522	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	916061	45655522	13473461	675	1388										
CD3EAP	10849	broad.mit.edu	37	chr19	45910365	45910365	+	Frame_Shift_Del	DEL	C	C	-													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgcagatgctgctcggttCtcttgtccccccaactttac					rs117289933	byFrequency	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:45910365delC	uc002pbq.1	+	2	524	c.36delC	c.(34-36)TTCfs	p.F12fs	PPP1R13L_uc002pbn.2_5'Flank|PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Frame_Shift_Del_p.F14fs	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	12					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		CTGCTCGGTTCTCTTGTCCCC	0.592																		52	163	---	---								-	45910365	C	-	45910365	7	5	6	1	0	1	0	1	0	0	0	0	3012	912	32	0	42	0	CD3EAP	19	45910365	Frame_Shift_Del	DEL	C	TCGA-BT-A0YX-01A-11D-A10S-08	254843	45910365	13218618	676	1389										
KCNJ14	3770	broad.mit.edu	37	chr19	48967834	48967834	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggagctggatgaacgggcaGagcaggcttcccacagcctc	14	12	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:48967834G>C	uc002pje.1	+	3	1516	c.1111G>C	c.(1111-1113)GAG>CAG	p.E371Q	KCNJ14_uc002pjf.1_Missense_Mutation_p.E371Q	NM_013348	NP_037480	Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel J14	371	Cytoplasmic (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		TGAACGGGCAGAGCAGGCTTC	0.552													0	0	0	0.006122	0	17	68										C	48967834	G	C	48967834	3	2	6	1	0	0	0	0	1	0	0	0	8048	943	33	1	1117	1	KCNJ14	19	48967834	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3057469	48967834	10161149	677	1390										
SPHK2	56848	broad.mit.edu	37	chr19	49132338	49132338	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gttctgtgtctgacctgcctCttcccctgccccagcctgcc	8	19	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:49132338C>G	uc002pjr.2	+	7	1639	c.1273C>G	c.(1273-1275)CTT>GTT	p.L425V	SPHK2_uc010xzt.1_Missense_Mutation_p.L366V|SPHK2_uc002pjs.2_Missense_Mutation_p.L425V|SPHK2_uc002pjt.2_Missense_Mutation_p.L219V|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Missense_Mutation_p.L389V|SPHK2_uc002pjw.2_Missense_Mutation_p.L487V	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	425					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		tgacctgcctcttcccctgcc	0.348													0	0	0	0.006214	0	9	45										G	49132338	C	G	49132338	3	3	6	1	0	0	0	0	1	0	0	0	15046	913	32	1	1295	1	SPHK2	19	49132338	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	164504	49132338	9996645	678	1391										
SPHK2	56848	broad.mit.edu	37	chr19	49132817	49132817	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgcgctgctgcgccttttCttggccatggagcgtggtag	15	11	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:49132817C>G	uc002pjr.2	+	7	2118	c.1752C>G	c.(1750-1752)TTC>TTG	p.F584L	SPHK2_uc010xzt.1_Missense_Mutation_p.F525L|SPHK2_uc002pjs.2_Missense_Mutation_p.F584L|SPHK2_uc002pjt.2_Missense_Mutation_p.F378L|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Missense_Mutation_p.F548L|SPHK2_uc002pjw.2_Missense_Mutation_p.F646L	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	584					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TGCGCCTTTTCTTGGCCATGG	0.701													0	0	0	0.004672	0	2	6										G	49132817	C	G	49132817	3	3	6	1	0	0	0	0	1	0	0	0	15046	912	32	1	1774	1	SPHK2	19	49132817	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	479	49132817	9996166	679	1392										
PLEKHA4	57664	broad.mit.edu	37	chr19	49362759	49362759	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccctccgcatctggagtccaGagtggaggtcggttgtgggg	17	10	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:49362759G>C	uc002pkx.2	-	7	1210	c.659C>G	c.(658-660)TCT>TGT	p.S220C	PLEKHA4_uc002pkw.1_5'Flank|PLEKHA4_uc010eml.2_Missense_Mutation_p.S220C	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	220	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CTGGAGTCCAGAGTGGAGGTC	0.632													0	0	0	0.00499	0	17	62										C	49362759	G	C	49362759	3	2	6	1	0	0	0	0	1	0	0	0	12058	942	33	1	1736	1	PLEKHA4	19	49362759	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	229942	49362759	9766224	680	1393										
SLC6A16	28968	broad.mit.edu	37	chr19	49814319	49814319	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggcaaggaggacctcactctCtttcttctctgtcatctgca	8	13	6	0	rs148710394	by1000genomes	TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:49814319C>G	uc002pmz.2	-	2	520	c.286G>C	c.(286-288)GAG>CAG	p.E96Q	SLC6A16_uc002pna.2_Missense_Mutation_p.E96Q|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	96	Cytoplasmic (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		ACCTCACTCTCTTTCTTCTCT	0.517													0	0	0	0.008361	0	27	92										G	49814319	C	G	49814319	3	3	6	1	0	0	0	0	1	0	0	0	14679	922	32	1	1968	1	SLC6A16	19	49814319	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	451560	49814319	9314664	681	1394										
PRR12	57479	broad.mit.edu	37	chr19	50099726	50099726	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gcaccagtgccagcctggatGagggtgccactgcggcactg	15	13	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:50099726G>A	uc002poo.3	+	4	2134	c.2134G>A	c.(2134-2136)GAG>AAG	p.E712K		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CAGCCTGGATGAGGGTGCCAC	0.682													0	0	0	0.001984	0	7	12										A	50099726	G	A	50099726	3	1	6	1	0	0	0	0	1	0	0	0	12584	1291	45	1	2148	1	PRR12	19	50099726	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	285407	50099726	9029257	682	1395										
CPT1C	126129	broad.mit.edu	37	chr19	50209292	50209292	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctggagcagcagtttcagaGaatcctggatgatccctcac	10	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:50209292G>A	uc002ppj.2	+	10	1296	c.1091G>A	c.(1090-1092)AGA>AAA	p.R364K	CPT1C_uc002ppl.3_Missense_Mutation_p.R330K|CPT1C_uc002ppi.2_Missense_Mutation_p.R281K|CPT1C_uc002ppk.2_Missense_Mutation_p.R353K|CPT1C_uc010eng.2_Missense_Mutation_p.R364K|CPT1C_uc010enh.2_Missense_Mutation_p.R364K|CPT1C_uc010ybc.1_Missense_Mutation_p.R235K|CPT1C_uc010eni.1_Missense_Mutation_p.R21K	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	364	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CAGTTTCAGAGAATCCTGGAT	0.632													0	0	0	0.012319	0	22	69										A	50209292	G	A	50209292	3	1	6	1	0	0	0	0	1	0	0	0	3833	942	33	1	1125	1	CPT1C	19	50209292	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	109566	50209292	8919691	683	1396										
ZNF845	91664	broad.mit.edu	37	chr19	53855026	53855026	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtgacaaagctttcagtttCaaatcaaaccttgaaagaca	6	8	3	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:53855026C>G	uc010ydv.1	+	4	1215	c.1098C>G	c.(1096-1098)TTC>TTG	p.F366L	ZNF845_uc010ydw.1_Missense_Mutation_p.F366L	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	366	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTCAGTTTCAAATCAAACC	0.398													0	0	0	0.00333	0	24	71										G	53855026	C	G	53855026	3	3	6	1	0	0	0	0	1	0	0	0	18188	825	29	1	1108	1	ZNF845	19	53855026	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	3645734	53855026	5273957	684	1397										
CNOT3	4849	broad.mit.edu	37	chr19	54646863	54646863	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctccctggccaggtgagattGatcgctgcctcaagaaggtg	13	11	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:54646863G>C	uc002qdj.1	+	3	345	c.34G>C	c.(34-36)GAT>CAT	p.D12H	CNOT3_uc010yel.1_Missense_Mutation_p.D12H|CNOT3_uc002qdi.2_5'UTR|CNOT3_uc002qdk.1_Missense_Mutation_p.D12H|CNOT3_uc010ere.1_5'Flank	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	12					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGGTGAGATTGATCGCTGCCT	0.537													0	0	0	0.009718	0	36	247										C	54646863	G	C	54646863	3	2	6	1	0	0	0	0	1	0	0	0	3620	1290	45	1	40	1	CNOT3	19	54646863	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	791837	54646863	4482120	685	1398										
CNOT3	4849	broad.mit.edu	37	chr19	54646887	54646887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gctgcctcaagaaggtgtccGagggcgtggagcagtttgaa	16	8	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:54646887G>A	uc002qdj.1	+	3	369	c.58G>A	c.(58-60)GAG>AAG	p.E20K	CNOT3_uc010yel.1_Missense_Mutation_p.E20K|CNOT3_uc002qdi.2_5'UTR|CNOT3_uc002qdk.1_Missense_Mutation_p.E20K|CNOT3_uc010ere.1_5'Flank	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	20					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding	p.E20K(1)		ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAAGGTGTCCGAGGGCGTGGA	0.557													0	0	0	0.005524	0	32	239										A	54646887	G	A	54646887	3	1	6	1	0	0	0	0	1	0	0	0	3620	1059	37	1	64	1	CNOT3	19	54646887	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	24	54646887	4482096	686	1399										
LILRB3	11025	broad.mit.edu	37	chr19	54724400	54724400	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cggggtcagcgccctcacctGagaccacgagctccaggggc	14	16	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:54724400G>A	uc002qef.1	-	6	1367	c.1256C>T	c.(1255-1257)TCA>TTA	p.S419L	LILRB3_uc002qee.1_Missense_Mutation_p.S419L|LILRB3_uc002qeh.1_Missense_Mutation_p.S419L|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.S419L|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Missense_Mutation_p.S419L|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Missense_Mutation_p.S419L|LILRB3_uc002qep.1_Missense_Mutation_p.S419L|LILRB3_uc002qeq.1_Missense_Mutation_p.S419L|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.S419L|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	419	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCCCTCACCTGAGACCACGAG	0.667													0	0	0	0.010729	0	10	33										A	54724400	G	A	54724400	3	1	6	1	0	0	0	0	1	0	0	0	8792	1294	45	1	674	1	LILRB3	19	54724400	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	77513	54724400	4404583	687	1400										
LILRB3	11025	broad.mit.edu	37	chr19	54746131	54746131	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	caccagatggtcacggggctCccccagctgatcacagagcc	11	16	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:54746131C>T	uc010erh.1	-	3	250	c.126G>A	c.(124-126)GGG>GGA	p.G42G	LILRA6_uc002qew.1_Silent_p.G42G|LILRB3_uc002qeh.1_Silent_p.G42G|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Silent_p.G42G|LILRA6_uc002qek.1_Silent_p.G42G|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Silent_p.G42G|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.G42G|LILRB3_uc002qep.1_Silent_p.G42G|LILRB3_uc002qeq.1_Silent_p.G42G|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.G42G|LILRA6_uc010yep.1_Silent_p.G42G|LILRA6_uc010yeq.1_Silent_p.G42G|LILRA6_uc002qet.3_RNA|LILRA6_uc002qeu.1_Silent_p.G42G|LILRA6_uc002qev.1_5'Flank	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	42	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACGGGGCTCCCCCAGCTGA	0.602													0	0	0	0.005443	0	27	169										T	54746131	C	T	54746131	2	4	6	1	0	0	0	0	0	0	0	1	8792	842	30	1		1	LILRB3	19	54746131	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	21731	54746131	4382852	688	1401										
PPP1R12C	54776	broad.mit.edu	37	chr19	55610164	55610164	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acactcacgtcctcctgtttCcgggccagttcctccaacag	7	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:55610164C>A	uc002qix.2	-	6	955	c.939G>T	c.(937-939)CGG>CGT	p.R313R	PPP1R12C_uc010yfs.1_Silent_p.R239R|PPP1R12C_uc002qiy.2_Silent_p.R313R	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	313	Potential.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCTCCTGTTTCCGGGCCAGTT	0.637													1	0	4.4004e-07	0.00333	4.48252e-07	22	86										A	55610164	C	A	55610164	2	1	6	1	0	0	0	0	0	0	0	1	12356	842	30	3		3	PPP1R12C	19	55610164	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	864033	55610164	3518819	689	1402										
SYT5	6861	broad.mit.edu	37	chr19	55689630	55689630	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acctgggcttgggcctggctCttcttgcctgtccgcctccg	12	16	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:55689630C>T	uc002qjm.1	-	2	1246	c.186G>A	c.(184-186)AAG>AAA	p.K62K	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Silent_p.K62K|SYT5_uc002qjo.1_Silent_p.K62K	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	62	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGGCCTGGCTCTTCTTGCCTG	0.632													0	0	0	0.000602	0	3	12										T	55689630	C	T	55689630	2	4	6	1	0	0	0	0	0	0	0	1	15474	912	32	1		1	SYT5	19	55689630	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	79466	55689630	3439353	690	1403										
ZNF17	7565	broad.mit.edu	37	chr19	57932476	57932476	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gaaattctttaggcacaactCaaatcatattagacatcgga	6	8	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:57932476C>G	uc002qoo.1	+	3	1847	c.1616C>G	c.(1615-1617)TCA>TGA	p.S539*	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Nonsense_Mutation_p.S541*	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	539	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		AGGCACAACTCAAATCATATT	0.423													0	0	0	0.00333	0	26	96										G	57932476	C	G	57932476	4	3	6	1	0	0	0	0	0	1	0	0	17740	838	29	1	1626	1	ZNF17	19	57932476	Nonsense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2242846	57932476	1196507	691	1404										
ZNF324	25799	broad.mit.edu	37	chr19	58982927	58982927	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttcagccacggctccaacctCagccagcaccgcaagatcca	7	18	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr19:58982927C>G	uc002qsw.1	+	4	1162	c.1068C>G	c.(1066-1068)CTC>CTG	p.L356L	ZNF324_uc002qsx.1_Silent_p.L133L	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	356	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCTCCAACCTCAGCCAGCACC	0.662													0	0	0	0.001984	0	4	14										G	58982927	C	G	58982927	2	3	6	1	0	0	0	0	0	0	0	1	17841	813	29	1		1	ZNF324	19	58982927	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1050451	58982927	146056	692	1405										
JAG1	182	broad.mit.edu	37	chr20	10632342	10632342	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagagaggcaggcgtgctcaGctgcaaaaaccaggatggca	14	10	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:10632342G>T	uc002wnw.2	-	8	1523	c.1007C>A	c.(1006-1008)GCT>GAT	p.A336D	JAG1_uc010gcd.1_5'Flank	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	336	Extracellular (Potential).|EGF-like 4.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GGCGTGCTCAGCTGCAAAAAC	0.607									Alagille_Syndrome				1	0	8.12818e-05	0.001984	8.22569e-05	6	20										T	10632342	G	T	10632342	3	4	6	1	0	0	0	0	1	0	0	0	7934	985	34	4	2725	4	JAG1	20	10632342	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		10632342	52393178	693	1406										
ISM1	140862	broad.mit.edu	37	chr20	13251215	13251215	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttctctctccaaagaagcacCaagggagcatctggaccacc	8	14	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:13251215C>A	uc010gce.1	+	2	209	c.203C>A	c.(202-204)CCA>CAA	p.P68Q	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	68						extracellular region					0						AAAGAAGCACCAAGGGAGCAT	0.502													1	0	0.00185496	0.001855	0.00187312	12	42										A	13251215	C	A	13251215	3	1	6	1	0	0	0	0	1	0	0	0	7860	594	21	4	209	4	ISM1	20	13251215	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2618873	13251215	49774305	694	1407										
SEL1L2	80343	broad.mit.edu	37	chr20	13850838	13850838	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaccaagcccatgaaggccGattgcattgccctagaagag	11	11	0	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:13850838G>C	uc010gcf.2	-	13	1198	c.1116C>G	c.(1114-1116)ATC>ATG	p.I372M	SEL1L2_uc002woq.3_Missense_Mutation_p.I233M|SEL1L2_uc010zrl.1_Missense_Mutation_p.I372M|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	372	Extracellular (Potential).|Sel1-like 7.					integral to membrane	binding			ovary(2)	2						CATGAAGGCCGATTGCATTGC	0.333													0	0	0	0.005443	0	26	85										C	13850838	G	C	13850838	3	2	6	1	0	0	0	0	1	0	0	0	14011	1048	37	1	982	1	SEL1L2	20	13850838	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	599623	13850838	49174682	695	1408										
FOXA2	3170	broad.mit.edu	37	chr20	22563340	22563340	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtcagcatcttgttggggctCtgctggatggccatggtgat	15	8	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:22563340C>G	uc002wsn.2	-	3	712	c.522G>C	c.(520-522)CAG>CAC	p.Q174H	FOXA2_uc002wsm.2_Missense_Mutation_p.Q180H	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	174	Fork-head.				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					TGTTGGGGCTCTGCTGGATGG	0.617													0	0	0	0.010771	0	41	117										G	22563340	C	G	22563340	3	3	6	1	0	0	0	0	1	0	0	0	5990	912	32	1	855	1	FOXA2	20	22563340	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	8712502	22563340	40462180	696	1409										
ABHD12	26090	broad.mit.edu	37	chr20	25295601	25295601	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acatggtaaccaagggaactCagcacctgtaaagtgaaaaa	9	8	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:25295601C>G	uc002wus.1	-	6	717	c.579G>C	c.(577-579)CTG>CTC	p.L193L	ABHD12_uc002wuq.2_Silent_p.L193L|ABHD12_uc002wur.2_Silent_p.L193L|ABHD12_uc002wut.1_Silent_p.L193L|ABHD12_uc002wuu.1_5'UTR	NM_001042472	NP_001035937	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform a	193	Extracellular (Potential).					integral to membrane	acylglycerol lipase activity			skin(1)	1						CAAGGGAACTCAGCACCTGTA	0.448													0	0	0	0.014323	0	22	91										G	25295601	C	G	25295601	2	3	6	1	0	0	0	0	0	0	0	1	76	813	29	1		1	ABHD12	20	25295601	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2732261	25295601	37729919	697	1410										
C20orf70	140683	broad.mit.edu	37	chr20	31760844	31760844	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagaaattgctgaacaatgtCatttctaagctgcttccaac	7	9	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:31760844C>T	uc002wyo.1	+	3	335	c.264C>T	c.(262-264)GTC>GTT	p.V88V		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	88						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						TGAACAATGTCATTTCTAAGC	0.463													0	0	0	0.005443	0	26	62										T	31760844	C	T	31760844	2	4	6	1	0	0	0	0	0	0	0	1	2116	813	29	1		1	C20orf70	20	31760844	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6465243	31760844	31264676	698	1411										
C20orf71	128861	broad.mit.edu	37	chr20	31813019	31813019	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgataggcaaatgcgatgcaGagcccagcagtgtccatgtg	13	9	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:31813019G>C	uc002wyr.2	+	4	710	c.502G>C	c.(502-504)GAG>CAG	p.E168Q	C20orf71_uc002wys.2_Missense_Mutation_p.E132Q	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	168						extracellular region	lipid binding			ovary(1)|skin(1)	2						ATGCGATGCAGAGCCCAGCAG	0.572													0	0	0	0.00874	0	42	132										C	31813019	G	C	31813019	3	2	6	1	0	0	0	0	1	0	0	0	2117	943	33	1	516	1	C20orf71	20	31813019	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	52175	31813019	31212501	699	1412										
CPNE1	8904	broad.mit.edu	37	chr20	34220101	34220101	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acaccttcttatctaggtttCtggcctctacctccatggtt	6	13	4	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:34220101C>G	uc002xdf.2	-	7	803	c.440G>C	c.(439-441)AGA>ACA	p.R147T	CPNE1_uc002xdc.2_5'Flank|CPNE1_uc010zvj.1_Missense_Mutation_p.R152T|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdg.2_Missense_Mutation_p.R147T|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.R147T|CPNE1_uc002xdi.2_Missense_Mutation_p.R147T|CPNE1_uc002xdj.2_Missense_Mutation_p.R147T|CPNE1_uc002xdk.2_Missense_Mutation_p.R147T|CPNE1_uc002xdl.2_Missense_Mutation_p.R147T|CPNE1_uc002xdm.2_Missense_Mutation_p.R147T|CPNE1_uc010gfk.1_Missense_Mutation_p.R147T	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	147	C2 2.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			ATCTAGGTTTCTGGCCTCTAC	0.483													0	0	0	0.004656	0	21	69										G	34220101	C	G	34220101	3	3	6	1	0	0	0	0	1	0	0	0	3811	913	32	1	1221	1	CPNE1	20	34220101	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2407082	34220101	28805419	700	1413										
CTNNBL1	56259	broad.mit.edu	37	chr20	36488327	36488327	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtccggcgaggagagatcatCgacaatgacaccgaggagga	15	9	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:36488327C>T	uc010zvw.1	+	15	1510	c.1419C>T	c.(1417-1419)ATC>ATT	p.I473I	CTNNBL1_uc002xhh.2_Silent_p.I286I|CTNNBL1_uc002xhi.2_RNA|CTNNBL1_uc002xhj.2_Silent_p.I221I	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	473					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				GAGAGATCATCGACAATGACA	0.522													0	0	0	0.00308	0	8	52										T	36488327	C	T	36488327	2	4	6	1	0	0	0	0	0	0	0	1	4018	874	31	1		1	CTNNBL1	20	36488327	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2268226	36488327	26537193	701	1414										
BPI	671	broad.mit.edu	37	chr20	36948673	36948673	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gagaccctggatgtacagatGaaggtgaggctgacactgag	15	7	0	6			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:36948673G>A	uc002xib.2	+	7	827	c.765G>A	c.(763-765)ATG>ATA	p.M255I		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	255					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				ATGTACAGATGAAGGTGAGGC	0.468													0	0	0	0.001168	0	6	42										A	36948673	G	A	36948673	3	1	6	1	0	0	0	0	1	0	0	0	1490	1290	45	1	791	1	BPI	20	36948673	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	460346	36948673	26076847	702	1415										
TOP1	7150	broad.mit.edu	37	chr20	39708734	39708734	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tttctctttagtccaccacaAattaaagatgaacctgaaga	5	9	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:39708734A>T	uc002xjl.2	+	6	591	c.345A>T	c.(343-345)CAA>CAT	p.Q115H	TOP1_uc010gge.1_RNA	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	115	Lys-rich.				DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	GTCCACCACAAATTAAAGATG	0.348			T	NUP98	AML*								0	0	0	0.00245	0	13	52										T	39708734	A	T	39708734	3	4	6	1	0	0	0	0	1	0	0	0	16360	11	1	5	367	5	TOP1	20	39708734	Missense_Mutation	SNP	A	TCGA-BT-A0YX-01A-11D-A10S-08	2760061	39708734	23316786	703	1416										
SEMG2	6407	broad.mit.edu	37	chr20	43850714	43850714	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatccttctcaagatcagggGaatagcccatctggaaaggg	11	9	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:43850714G>A	uc010ggz.2	+	2	498	c.441G>A	c.(439-441)GGG>GGA	p.G147G	SEMG2_uc002xnk.2_Silent_p.G147G|SEMG2_uc002xnl.2_Silent_p.G147G	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	147	Repeat-rich region.|2-1.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AAGATCAGGGGAATAGCCCAT	0.408													0	0	0	0.010504	0	22	65										A	43850714	G	A	43850714	2	1	6	1	0	0	0	0	0	0	0	1	14045	1161	41	1		1	SEMG2	20	43850714	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4141980	43850714	19174806	704	1417										
SEMG2	6407	broad.mit.edu	37	chr20	43850728	43850728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaggggaatagcccatctgGaaagggattatccagtcaat	11	8	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:43850728G>A	uc010ggz.2	+	2	512	c.455G>A	c.(454-456)GGA>GAA	p.G152E	SEMG2_uc002xnk.2_Missense_Mutation_p.G152E|SEMG2_uc002xnl.2_Missense_Mutation_p.G152E	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	152	Repeat-rich region.|2-1.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AGCCCATCTGGAAAGGGATTA	0.408													0	0	0	0.012319	0	23	70										A	43850728	G	A	43850728	3	1	6	1	0	0	0	0	1	0	0	0	14045	1174	41	1	461	1	SEMG2	20	43850728	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14	43850728	19174792	705	1418										
ZNF335	63925	broad.mit.edu	37	chr20	44577600	44577600	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggccctcggggctcagtcatCggccagggtgatgacgtcgt	16	12	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:44577600C>T	uc002xqw.2	-	28	4144	c.4021G>A	c.(4021-4023)GAT>AAT	p.D1341N	ZNF335_uc002xqv.2_Missense_Mutation_p.D453N|ZNF335_uc010zxk.1_Missense_Mutation_p.D1186N	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GCTCAGTCATCGGCCAGGGTG	0.607													0	0	0	0.003954	0	23	68										T	44577600	C	T	44577600	3	4	6	1	0	0	0	0	1	0	0	0	17849	884	31	1	11	1	ZNF335	20	44577600	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	726872	44577600	18447920	706	1419										
PTGIS	5740	broad.mit.edu	37	chr20	48130897	48130897	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcaggattcttgagaaggaaGagcaggagccagaaggcagc	15	7	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:48130897G>C	uc002xut.2	-	7	945	c.891C>G	c.(889-891)CTC>CTG	p.L297L	PTGIS_uc010zyi.1_Silent_p.L158L	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	297					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TGAGAAGGAAGAGCAGGAGCC	0.597													0	0	0	0.00499	0	14	54										C	48130897	G	C	48130897	2	2	6	1	0	0	0	0	0	0	0	1	12752	929	33	1		1	PTGIS	20	48130897	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	3553297	48130897	14894623	707	1420										
SLC9A8	23315	broad.mit.edu	37	chr20	48497480	48497480	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtgcttgtactatttggcaGagcggtaaacattttccctc	10	9	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:48497480G>C	uc002xuv.1	+	13	1388	c.1178G>C	c.(1177-1179)AGA>ACA	p.R393T	SLC9A8_uc010zym.1_Missense_Mutation_p.R93T|SLC9A8_uc010gic.2_Missense_Mutation_p.R93T|SLC9A8_uc010gid.2_Missense_Mutation_p.R17T	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	393	Helical; (Potential).					Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			CTATTTGGCAGAGCGGTAAAC	0.413													0	0	0	0.012213	0	33	127										C	48497480	G	C	48497480	3	2	6	1	0	0	0	0	1	0	0	0	14720	942	33	1	1228	1	SLC9A8	20	48497480	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	366583	48497480	14528040	708	1421										
SALL4	57167	broad.mit.edu	37	chr20	50408216	50408216	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgagcaaagccacagctgcaGaaacctgctgagacatgtgg	12	10	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:50408216G>C	uc002xwh.3	-	2	907	c.806C>G	c.(805-807)TCT>TGT	p.S269C	SALL4_uc010gii.2_Missense_Mutation_p.S269C|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	269					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CACAGCTGCAGAAACCTGCTG	0.592													0	0	0	0.004007	0	5	30										C	50408216	G	C	50408216	3	2	6	1	0	0	0	0	1	0	0	0	13813	942	33	1	2367	1	SALL4	20	50408216	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1910736	50408216	12617304	709	1422										
C20orf177	63939	broad.mit.edu	37	chr20	58520007	58520007	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ctgtgattctggactcagcaGattcctgtaaggcctccaaa	9	11	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:58520007G>C	uc002yba.2	+	5	1424	c.1009G>C	c.(1009-1011)GAT>CAT	p.D337H	C20orf177_uc010zzx.1_Missense_Mutation_p.D180H|C20orf177_uc002ybc.2_Missense_Mutation_p.D337H	NM_022106	NP_071389	Q9NTX9	CT177_HUMAN	hypothetical protein LOC63939	337										ovary(2)|breast(1)	3	all_lung(29;0.00693)		BRCA - Breast invasive adenocarcinoma(7;1.22e-08)			GGACTCAGCAGATTCCTGTAA	0.517													0	0	0	0.00499	0	17	54										C	58520007	G	C	58520007	3	2	6	1	0	0	0	0	1	0	0	0	2096	942	33	1	1011	1	C20orf177	20	58520007	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	8111791	58520007	4505513	710	1423										
LAMA5	3911	broad.mit.edu	37	chr20	60921260	60921260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gccatccgtgaagtcggactCgcagttgcagcctgggcagg	15	12	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:60921260C>T	uc002ycq.2	-	10	1361	c.1294G>A	c.(1294-1296)GAG>AAG	p.E432K		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	432	Laminin EGF-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGTCGGACTCGCAGTTGCAG	0.647													0	0	0	0.008291	0	11	19										T	60921260	C	T	60921260	3	4	6	1	0	0	0	0	1	0	0	0	8609	893	31	1	10077	1	LAMA5	20	60921260	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2401253	60921260	2104260	711	1424										
UCKL1	54963	broad.mit.edu	37	chr20	62577259	62577259	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggaaatgatgaggtcgaagtCaaaggcatctgggtggtcga	16	5	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr20:62577259C>T	uc010gkn.2	-	4	524	c.481G>A	c.(481-483)GAC>AAC	p.D161N	UCKL1_uc011abm.1_Missense_Mutation_p.D146N|UCKL1_uc011abn.1_RNA|UCKL1_uc011abo.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	161					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					AGGTCGAAGTCAAAGGCATCT	0.562													0	0	0	0.01441	0	86	284										T	62577259	C	T	62577259	3	4	6	1	0	0	0	0	1	0	0	0	16922	826	29	1	1213	1	UCKL1	20	62577259	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1655999	62577259	448261	712	1425										
LIPI	149998	broad.mit.edu	37	chr21	15561577	15561577	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actgttttcttttgtgtgttGaaattaacattaagtgagtt	8	3	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:15561577G>A	uc002yjm.2	-	2	283	c.273C>T	c.(271-273)TTC>TTT	p.F91F	LIPI_uc010gkw.1_Silent_p.F24F	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	70					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTTGTGTGTTGAAATTAACAT	0.383													0	0	0	0.010818	0	31	89										A	15561577	G	A	15561577	2	1	6	1	0	0	0	0	0	0	0	1	8825	1281	45	1		1	LIPI	21	15561577	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		15561577	32568318	713	1426										
NCAM2	4685	broad.mit.edu	37	chr21	22910264	22910264	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcattcaatcaaaagaagacGacagcaaagcataacaacaa	5	9	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:22910264G>C	uc002yld.1	+	18	2749	c.2500G>C	c.(2500-2502)GAC>CAC	p.D834H	NCAM2_uc011acb.1_Missense_Mutation_p.D692H	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	834	Cytoplasmic (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AAAAGAAGACGACAGCAAAGC	0.358													0	0	0	0.006214	0	10	64										C	22910264	G	C	22910264	3	2	6	1	0	0	0	0	1	0	0	0	10203	1058	37	1	2570	1	NCAM2	21	22910264	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7348687	22910264	25219631	714	1427										
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744044	31744044	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aggttgatccataggctggtCtgtaacaaggagactggcag	14	7	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:31744044C>G	uc002ynz.3	-	1	514	c.488G>C	c.(487-489)AGA>ACA	p.R163T		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	163						intermediate filament					0						ATAGGCTGGTCTGTAACAAGG	0.493													0	0	0	0.006122	0	12	47										G	31744044	C	G	31744044	3	3	6	1	0	0	0	0	1	0	0	0	8523	913	32	1	43	1	KRTAP13-2	21	31744044	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	8833780	31744044	16385851	715	1428										
TRAPPC10	7109	broad.mit.edu	37	chr21	45514011	45514011	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gacagaagagcctcccccttCtctgcattgccggttctctg	9	15	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:45514011C>G	uc002zea.2	+	20	3234	c.3065C>G	c.(3064-3066)TCT>TGT	p.S1022C	TRAPPC10_uc010gpo.2_Missense_Mutation_p.S733C|TRAPPC10_uc011afa.1_Missense_Mutation_p.S400C|TRAPPC10_uc011afb.1_Missense_Mutation_p.S127C	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1022					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCTCCCCCTTCTCTGCATTGC	0.478													0	0	0	0.009718	0	39	176										G	45514011	C	G	45514011	3	3	6	1	0	0	0	0	1	0	0	0	16454	913	32	1	3143	1	TRAPPC10	21	45514011	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	13769967	45514011	2615884	716	1429										
TRAPPC10	7109	broad.mit.edu	37	chr21	45514050	45514050	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgttggattttccccagcttCtgaggaacagctgtctatct	9	10	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:45514050C>G	uc002zea.2	+	20	3273	c.3104C>G	c.(3103-3105)TCT>TGT	p.S1035C	TRAPPC10_uc010gpo.2_Missense_Mutation_p.S746C|TRAPPC10_uc011afa.1_Missense_Mutation_p.S413C|TRAPPC10_uc011afb.1_Missense_Mutation_p.S140C	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1035					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TCCCCAGCTTCTGAGGAACAG	0.448													0	0	0	0.010771	0	40	181										G	45514050	C	G	45514050	3	3	6	1	0	0	0	0	1	0	0	0	16454	913	32	1	3182	1	TRAPPC10	21	45514050	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	39	45514050	2615845	717	1430										
TRAPPC10	7109	broad.mit.edu	37	chr21	45518306	45518306	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tattgcagaacaggctccctCtgctccctggaggttttgat	10	11	1	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:45518306C>G	uc002zea.2	+	21	3406	c.3237C>G	c.(3235-3237)CTC>CTG	p.L1079L	TRAPPC10_uc010gpo.2_Silent_p.L790L|TRAPPC10_uc011afa.1_Silent_p.L457L|TRAPPC10_uc011afb.1_Silent_p.L184L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1079					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAGGCTCCCTCTGCTCCCTGG	0.473													0	0	0	0.01441	0	54	188										G	45518306	C	G	45518306	2	3	6	1	0	0	0	0	0	0	0	1	16454	900	32	1		1	TRAPPC10	21	45518306	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4256	45518306	2611589	718	1431										
AIRE	326	broad.mit.edu	37	chr21	45706995	45706995	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccgcgccagcagccctgactCcaaggggcaccgccagccca	11	20	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr21:45706995C>G	uc002zei.2	+	3	569	c.442C>G	c.(442-444)CCA>GCA	p.P148A		NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	148					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		AGCCCTGACTCCAAGGGGCAC	0.716									Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				0	0	0	0.008291	0	4	23										G	45706995	C	G	45706995	3	3	6	1	0	0	0	0	1	0	0	0	437	855	30	1	452	1	AIRE	21	45706995	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	188689	45706995	2422900	719	1432										
PEX26	55670	broad.mit.edu	37	chr22	18566266	18566266	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gatgtggtgggtgcctggctCcaagacccagccaatcaaaa	12	11	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:18566266C>T	uc002znp.3	+	4	644	c.435C>T	c.(433-435)CTC>CTT	p.L145L	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Silent_p.L145L|PEX26_uc002znt.2_Silent_p.L145L	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	145	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						GTGCCTGGCTCCAAGACCCAG	0.527													0	0	0	0.00874	0	45	175										T	18566266	C	T	18566266	2	4	6	1	0	0	0	0	0	0	0	1	11746	842	30	1		1	PEX26	22	18566266	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08		18566266	32738300	720	1433										
ZNF70	7621	broad.mit.edu	37	chr22	24086954	24086954	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtgaggtgcgttaggtcctGagtcccctctgtctgtttct	12	10	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:24086954G>C	uc002zxs.2	-	2	835	c.374C>G	c.(373-375)TCA>TGA	p.S125*	ZNF70_uc002zxr.1_5'Flank	NM_021916	NP_068735	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	125						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GTTAGGTCCTGAGTCCCCTCT	0.562													0	0	0	0.01441	0	44	159										C	24086954	G	C	24086954	4	2	6	1	0	0	0	0	0	1	0	0	18100	1294	45	1	970	1	ZNF70	22	24086954	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	5520688	24086954	27217612	721	1434										
CRYBB1	1414	broad.mit.edu	37	chr22	27003913	27003914	+	Missense_Mutation	DNP	CC	CC	AT													0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tagctgctcgaccatgtgttCcagcgagggtactcgccctt					rs141811471		TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:27003913_27003914CC>AT	uc003acy.1	-	4	441_442	c.371_372GG>AT	c.(370-372)TGG>TAT	p.W124Y		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	124	Beta/gamma crystallin 'Greek key' 2.				visual perception		structural constituent of eye lens			ovary(1)	1						ACCATGTGTTCCAGCGAGGGTA	0.594													0	0	0	0.004672	0	21	53										AT	27003914	CC	AT	27003913	3	1	6	1	0	0	0	0	1	0	0	0	3910	856	30	3	398	3	CRYBB1	22	27003913	Missense_Mutation	DNP	CC	TCGA-BT-A0YX-01A-11D-A10S-08	2916959	27003913	24300653	722	1435										
AP1B1	162	broad.mit.edu	37	chr22	29752417	29752417	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aacgggcagcccgctcacctCtgggcctcgcggtcgtcctt	12	17	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:29752417C>T	uc003afj.2	-	6	898	c.714G>A	c.(712-714)CAG>CAA	p.Q238Q	AP1B1_uc003afi.2_Silent_p.Q238Q|AP1B1_uc003afk.2_Silent_p.Q238Q|AP1B1_uc003afl.2_Silent_p.Q238Q	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	238					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CCGCTCACCTCTGGGCCTCGC	0.637													0	0	0	0.010729	0	11	23										T	29752417	C	T	29752417	2	4	6	1	0	0	0	0	0	0	0	1	731	912	32	1		1	AP1B1	22	29752417	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	2748504	29752417	21552149	723	1436										
ASCC2	84164	broad.mit.edu	37	chr22	30188508	30188508	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cactttggttctcagcacctGagggatggtgaatggcctga	13	9	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:30188508G>A	uc003agr.2	-	18	2041	c.1936C>T	c.(1936-1938)CAG>TAG	p.Q646*	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Nonsense_Mutation_p.Q646*|ASCC2_uc011akr.1_Nonsense_Mutation_p.Q570*	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			CTCAGCACCTGAGGGATGGTG	0.562													0	0	0	0.009718	0	39	484										A	30188508	G	A	30188508	4	1	6	1	0	0	0	0	0	1	0	0	1032	1299	45	1	349	1	ASCC2	22	30188508	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	436091	30188508	21116058	724	1437										
ELFN2	114794	broad.mit.edu	37	chr22	37770273	37770273	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	atctccaggatggtcttcttGacgttgacagacttctgctt	9	10	4	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:37770273G>A	uc003asq.3	-	3	2088	c.1302C>T	c.(1300-1302)GTC>GTT	p.V434V		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	434	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					TGGTCTTCTTGACGTTGACAG	0.617													0	0	0	0.01441	0	58	197										A	37770273	G	A	37770273	2	1	6	1	0	0	0	0	0	0	0	1	5058	1277	45	1		1	ELFN2	22	37770273	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7581765	37770273	13534293	725	1438										
EIF3L	51386	broad.mit.edu	37	chr22	38273809	38273809	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gacaagatgttgcgcatgcaGaaaggtgacccacaagtcta	11	9	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:38273809G>C	uc003auf.2	+	11	1293	c.1206G>C	c.(1204-1206)CAG>CAC	p.Q402H	EIF3L_uc003aue.1_Missense_Mutation_p.Q402H|EIF3L_uc011ann.1_Missense_Mutation_p.Q354H|EIF3L_uc003aug.2_Missense_Mutation_p.Q294H|EIF3L_uc003auh.2_Missense_Mutation_p.Q135H	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	402						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						TGCGCATGCAGAAAGGTGACC	0.517													0	0	0	0.004656	0	25	80										C	38273809	G	C	38273809	3	2	6	1	0	0	0	0	1	0	0	0	5022	933	33	1	1248	1	EIF3L	22	38273809	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	503536	38273809	13030757	726	1439										
MKL1	57591	broad.mit.edu	37	chr22	40815081	40815081	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcgctccgagggggtgggaGacacggggggcgtggagccc	22	10	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:40815081G>C	uc003ayv.1	-	9	1568	c.1361C>G	c.(1360-1362)TCT>TGT	p.S454C	MKL1_uc003ayw.1_Missense_Mutation_p.S454C|MKL1_uc010gye.1_Missense_Mutation_p.S454C|MKL1_uc010gyf.1_Missense_Mutation_p.S404C	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	454					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGGGGTGGGAGACACGGGGGG	0.667			T	RBM15	acute megakaryocytic leukemia								0	0	0	0.009096	0	4	18										C	40815081	G	C	40815081	3	2	6	1	0	0	0	0	1	0	0	0	9601	942	33	1	1450	1	MKL1	22	40815081	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2541272	40815081	10489485	727	1440										
L3MBTL2	83746	broad.mit.edu	37	chr22	41626166	41626166	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ttgctgtgcgtgtgaaggaaGagcatctagacgtggcctcg	15	8	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:41626166G>C	uc003azo.2	+	17	2083	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	L3MBTL2_uc003azn.2_RNA|CHADL_uc003azq.3_Intron|CHADL_uc010gyj.2_Intron	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	677					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						TGTGAAGGAAGAGCATCTAGA	0.602													0	0	0	0.008871	0	20	74										C	41626166	G	C	41626166	3	2	6	1	0	0	0	0	1	0	0	0	8592	943	33	1	2095	1	L3MBTL2	22	41626166	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	811085	41626166	9678400	728	1441										
RIBC2	26150	broad.mit.edu	37	chr22	45818177	45818177	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgcctcctttcagaggccctCtacacagagacaaggctgca	9	14	2	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:45818177C>T	uc011aqs.1	+	5	758	c.549C>T	c.(547-549)CTC>CTT	p.L183L		NM_015653	NP_056468	Q9H4K1	RIBC2_HUMAN	RIB43A domain with coiled-coils 2	115											0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CAGAGGCCCTCTACACAGAGA	0.547													0	0	0	0.01441	0	68	225										T	45818177	C	T	45818177	2	4	6	1	0	0	0	0	0	0	0	1	13353	900	32	1		1	RIBC2	22	45818177	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	4192011	45818177	5486389	729	1442										
GTSE1	51512	broad.mit.edu	37	chr22	46693369	46693369	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgaacatggatgaccctaaGaaggaaggcaagtccttgct	12	8	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:46693369G>A	uc011aqy.1	+	2	284	c.72G>A	c.(70-72)AAG>AAA	p.K24K	CN5H6.4_uc003bhj.3_5'Flank|GTSE1_uc011aqz.1_5'UTR	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	5					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		ATGACCCTAAGAAGGAAGGCA	0.547													0	0	0	0.008361	0	23	97										A	46693369	G	A	46693369	2	1	6	1	0	0	0	0	0	0	0	1	6885	933	33	1		1	GTSE1	22	46693369	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	875192	46693369	4611197	730	1443										
PLXNB2	23654	broad.mit.edu	37	chr22	50721499	50721499	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	actttacacgggacgccgttGagggtcacccgcacgtcctc	11	15	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:50721499G>A	uc003bkv.3	-	17	2902	c.2796C>T	c.(2794-2796)CTC>CTT	p.L932L	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	932	Extracellular (Potential).|IPT/TIG 2.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGACGCCGTTGAGGGTCACCC	0.677													0	0	0	0.010729	0	11	17										A	50721499	G	A	50721499	2	1	6	1	0	0	0	0	0	0	0	1	12124	1277	45	1		1	PLXNB2	22	50721499	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	4028130	50721499	583067	731	1444										
CHKB	1120	broad.mit.edu	37	chr22	51020725	51020725	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aagcacctcccggggctcctCgccaacgctgggcaggtggt	14	15	0	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chr22:51020725C>T	uc003bms.2	-	2	504	c.286G>A	c.(286-288)GAG>AAG	p.E96K	CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_5'UTR|CHKB-CPT1B_uc003bmu.2_5'UTR|CHKB_uc003bmv.2_Missense_Mutation_p.E96K|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	96					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	CGGGGCTCCTCGCCAACGCTG	0.701													0	0	0	0.004672	0	3	8										T	51020725	C	T	51020725	3	4	6	1	0	0	0	0	1	0	0	0	3348	893	31	1	941	1	CHKB	22	51020725	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	299226	51020725	283841	732	1445										
ARSE	415	broad.mit.edu	37	chrX	2876407	2876407	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggtcgggaggcggaaatgtcGctggaagctgatggtgccaa	18	7	0	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:2876407G>A	uc004crc.3	-	3	343	c.93C>T	c.(91-93)AGC>AGT	p.S31S	ARSE_uc011mhi.1_Intron|ARSE_uc011mhh.1_Silent_p.S56S	NM_000047	NP_000038	P51690	ARSE_HUMAN	arylsulfatase E precursor	31					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			ovary(1)|central_nervous_system(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGAAATGTCGCTGGAAGCTG	0.552													0	0	0	0.012319	0	20	58										A	2876407	G	A	2876407	2	1	6	1	0	0	0	0	0	0	0	1	990	1078	38	2		2	ARSE	23	2876407	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08		2876407	152394153	733	1446										
PHKA2	5256	broad.mit.edu	37	chrX	18926150	18926150	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgaccccgtgctgtccagaGagatttgtgtcccagctggg	14	11	0	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:18926150G>C	uc004cyv.3	-	22	2815	c.2385C>G	c.(2383-2385)CTC>CTG	p.L795L	PHKA2_uc004cyu.3_Silent_p.L93L|PHKA2_uc010nfe.1_5'Flank|PHKA2_uc010nff.1_5'Flank	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	795					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GCTGTCCAGAGAGATTTGTGT	0.517													0	0	0	0.01441	0	67	321										C	18926150	G	C	18926150	2	2	6	1	0	0	0	0	0	0	0	1	11844	929	33	1		1	PHKA2	23	18926150	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	16049743	18926150	136344410	734	1447										
DMD	1756	broad.mit.edu	37	chrX	32429880	32429880	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tgtacttgcctgggcttcctGaggcatttgagctgcgtcca	12	11	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:32429880G>A	uc004dda.1	-	30	4466	c.4222C>T	c.(4222-4224)CAG>TAG	p.Q1408*	DMD_uc004dcw.2_Nonsense_Mutation_p.Q64*|DMD_uc004dcx.2_Nonsense_Mutation_p.Q67*|DMD_uc004dcz.2_Nonsense_Mutation_p.Q1285*|DMD_uc004dcy.1_Nonsense_Mutation_p.Q1404*|DMD_uc004ddb.1_Nonsense_Mutation_p.Q1400*|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1408					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGGGCTTCCTGAGGCATTTGA	0.398													0	0	0	0.010818	0	29	98										A	32429880	G	A	32429880	4	1	6	1	0	0	0	0	0	1	0	0	4580	1299	45	1	7183	1	DMD	23	32429880	Nonsense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	13503730	32429880	122840680	735	1448										
BCOR	54880	broad.mit.edu	37	chrX	39933287	39933287	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agacaagtctagtggcttatCtgtgacgtctttggtaacgg	12	7	3	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:39933287C>T	uc004den.3	-	4	1604	c.1312G>A	c.(1312-1314)GAT>AAT	p.D438N	BCOR_uc004dep.3_Missense_Mutation_p.D438N|BCOR_uc004deo.3_Missense_Mutation_p.D438N|BCOR_uc004dem.3_Missense_Mutation_p.D438N|BCOR_uc004deq.3_Missense_Mutation_p.D438N	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	438					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						AGTGGCTTATCTGTGACGTCT	0.532													0	0	0	0.008871	0	18	67										T	39933287	C	T	39933287	3	4	6	1	0	0	0	0	1	0	0	0	1386	913	32	1	4003	1	BCOR	23	39933287	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7503407	39933287	115337273	736	1449										
MED14	9282	broad.mit.edu	37	chrX	40568682	40568682	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cttgcatggacactgtcaatCaggagtttttctattgataa	8	7	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:40568682C>G	uc004dex.3	-	10	1343	c.1203G>C	c.(1201-1203)CTG>CTC	p.L401L	MED14_uc010nhe.1_Silent_p.L285L	NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	401	Interaction with STAT2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						CACTGTCAATCAGGAGTTTTT	0.353													0	0	0	0.00245	0	13	73										G	40568682	C	G	40568682	2	3	6	1	0	0	0	0	0	0	0	1	9432	813	29	1		1	MED14	23	40568682	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	635395	40568682	114701878	737	1450										
USP9X	8239	broad.mit.edu	37	chrX	41077663	41077663	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tctccttcgtcacagcaagaAtgtacgtttttggtttgctc	8	10	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:41077663A>T	uc004dfb.2	+	37	6881	c.6248A>T	c.(6247-6249)AAT>ATT	p.N2083I	USP9X_uc004dfc.2_Missense_Mutation_p.N2083I	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2083					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CACAGCAAGAATGTACGTTTT	0.373													0	0	0	0.01441	0	59	196										T	41077663	A	T	41077663	3	4	6	1	0	0	0	0	1	0	0	0	17087	101	4	5	6390	5	USP9X	23	41077663	Missense_Mutation	SNP	A	TCGA-BT-A0YX-01A-11D-A10S-08	508981	41077663	114192897	738	1451										
TBC1D25	4943	broad.mit.edu	37	chrX	48418785	48418785	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cagccagtcaggggcctggtGgtggggggcgtctcctgaga	19	10	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:48418785G>A	uc004dka.1	+	6	1600	c.1489G>A	c.(1489-1491)GGT>AGT	p.G497S	TBC1D25_uc011mly.1_Missense_Mutation_p.G439S|TBC1D25_uc004dkb.1_Missense_Mutation_p.G243S|TBC1D25_uc011mlz.1_Missense_Mutation_p.G243S|TBC1D25_uc011mma.1_Missense_Mutation_p.G243S|TBC1D25_uc004dkc.1_Missense_Mutation_p.G243S|TBC1D25_uc011mmb.1_Missense_Mutation_p.G501S|TBC1D25_uc011mmc.1_Missense_Mutation_p.G243S|TBC1D25_uc011mmd.1_Missense_Mutation_p.G243S	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	497	Poly-Gly.					intracellular	Rab GTPase activator activity			ovary(1)	1						GGGGCCTGGTGGTGGGGGGCG	0.642													0	0	0	0.008871	0	16	61										A	48418785	G	A	48418785	3	1	6	1	0	0	0	0	1	0	0	0	15612	1348	47	2	1511	2	TBC1D25	23	48418785	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	7341122	48418785	106851775	739	1452										
HUWE1	10075	broad.mit.edu	37	chrX	53587226	53587226	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtgtggccagtattggccgtCagctgccttagggtcctctg	14	11	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:53587226C>T	uc004dsp.2	-	56	8061	c.7659G>A	c.(7657-7659)CTG>CTA	p.L2553L	HUWE1_uc004dsn.2_Silent_p.L1377L|uc004dss.2_5'Flank|MIRLET7F2_hsa-let-7f-2|MI0000068_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2553					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TATTGGCCGTCAGCTGCCTTA	0.562													0	0	0	0.013537	0	8	27										T	53587226	C	T	53587226	2	4	6	1	0	0	0	0	0	0	0	1	7461	813	29	1		1	HUWE1	23	53587226	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	5168441	53587226	101683334	740	1453										
ITIH5L	347365	broad.mit.edu	37	chrX	54781511	54781511	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cctccagctcctcccaggatCtcctcagaattgccatccca	5	19	2	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:54781511C>T	uc004dtj.2	-	9	3171	c.3141G>A	c.(3139-3141)GAG>GAA	p.E1047E		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1047					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CTCCCAGGATCTCCTCAGAAT	0.488													0	0	0	0.005524	0	38	119										T	54781511	C	T	54781511	2	4	6	1	0	0	0	0	0	0	0	1	7908	912	32	1		1	ITIH5L	23	54781511	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	1194285	54781511	100489049	741	1454										
TRO	7216	broad.mit.edu	37	chrX	54956580	54956580	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accagtgtcagctttggtggTgctcatggcaccagcctctg	12	12	3	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:54956580T>C	uc004dtq.2	+	12	3530	c.3423T>C	c.(3421-3423)GGT>GGC	p.G1141G	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.G672G|TRO_uc004dtw.2_Silent_p.G744G|TRO_uc004dtx.2_Silent_p.G524G	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1141	34.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GCTTTGGTGGTGCTCATGGCA	0.567													0	0	0	0.008871	0	17	68										C	54956580	T	C	54956580	2	2	6	1	0	0	0	0	0	0	0	1	16571	1683	59	5		5	TRO	23	54956580	Silent	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	175069	54956580	100313980	742	1455										
DLG3	1741	broad.mit.edu	37	chrX	69719849	69719849	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tcgaggcgggccaatttaatGataacctctatgggaccagc	11	10	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:69719849G>A	uc004dyi.1	+	16	2423	c.2095G>A	c.(2095-2097)GAT>AAT	p.D699N	DLG3_uc004dyj.1_Missense_Mutation_p.D394N|DLG3_uc011mpn.1_Missense_Mutation_p.D247N	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	699	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					CCAATTTAATGATAACCTCTA	0.493													0	0	0	0.004482	0	9	38										A	69719849	G	A	69719849	3	1	6	1	0	0	0	0	1	0	0	0	4556	1290	45	1	2445	1	DLG3	23	69719849	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14763269	69719849	85550711	743	1456										
HDX	139324	broad.mit.edu	37	chrX	83723964	83723964	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ggatttccaagttttgtgttCtacagtaagggtctctaata	9	6	2	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:83723964C>T	uc004eek.1	-	3	876	c.767G>A	c.(766-768)AGA>AAA	p.R256K	HDX_uc011mqv.1_Missense_Mutation_p.R256K|HDX_uc004eel.1_Missense_Mutation_p.R198K	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	256						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GTTTTGTGTTCTACAGTAAGG	0.453													0	0	0	0.01441	0	47	163										T	83723964	C	T	83723964	3	4	6	1	0	0	0	0	1	0	0	0	7026	913	32	1	1337	1	HDX	23	83723964	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	14004115	83723964	71546596	744	1457										
DRP2	1821	broad.mit.edu	37	chrX	100497935	100497935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agcagctccaggatgcccacCgggactttgggcctgggtca	14	13	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:100497935C>T	uc004egz.2	+	9	1387	c.1018C>T	c.(1018-1020)CGG>TGG	p.R340W	DRP2_uc011mrh.1_Missense_Mutation_p.R262W	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	340					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GGATGCCCACCGGGACTTTGG	0.512													0	0	0	0.00874	0	43	181										T	100497935	C	T	100497935	3	4	6	1	0	0	0	0	1	0	0	0	4764	643	23	2	1044	2	DRP2	23	100497935	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	16773971	100497935	54772625	745	1458										
TAF7L	54457	broad.mit.edu	37	chrX	100537423	100537423	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	agaaaggtggatatcaccatCagcagtgcacacaagcatct	9	10	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:100537423C>T	uc004ehb.2	-	5	568	c.556G>A	c.(556-558)GAT>AAT	p.D186N	TAF7L_uc004eha.2_Missense_Mutation_p.D100N|TAF7L_uc004ehc.1_Missense_Mutation_p.D100N	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	186					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						ATATCACCATCAGCAGTGCAC	0.393													0	0	0	0.006122	0	18	87										T	100537423	C	T	100537423	3	4	6	1	0	0	0	0	1	0	0	0	15530	826	29	1	868	1	TAF7L	23	100537423	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	39488	100537423	54733137	746	1459										
GLRA4	441509	broad.mit.edu	37	chrX	102974114	102974114	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	acccaggacaggatgacgatGagtaggctggggatgtacat	15	7	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:102974114G>C	uc011mse.1	-	7	1225	c.804C>G	c.(802-804)CTC>CTG	p.L268L	GLRA4_uc010nou.2_Silent_p.L268L	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor	268	Helical; (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						GGATGACGATGAGTAGGCTGG	0.557													0	0	0	0.01441	0	60	248										C	102974114	G	C	102974114	2	2	6	1	0	0	0	0	0	0	0	1	6457	1277	45	1		1	GLRA4	23	102974114	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	2436691	102974114	52296446	747	1460										
RGAG1	57529	broad.mit.edu	37	chrX	109695177	109695177	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	accacctcactgatgacagtCccaagctctggagtgatgtc	9	13	2	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:109695177C>G	uc004eor.1	+	3	1578	c.1332C>G	c.(1330-1332)GTC>GTG	p.V444V	RGAG1_uc011msr.1_Silent_p.V444V	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	444										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TGATGACAGTCCCAAGCTCTG	0.512													0	0	0	0.01441	0	60	239										G	109695177	C	G	109695177	2	3	6	1	0	0	0	0	0	0	0	1	13274	842	30	1		1	RGAG1	23	109695177	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	6721063	109695177	45575383	748	1461										
LAMP2	3920	broad.mit.edu	37	chrX	119581866	119581866	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	cactgttgaagttttgtcttTatcacacaggaactctaaaa	6	8	3	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:119581866T>C	uc004est.3	-	5	751	c.571A>G	c.(571-573)AAA>GAA	p.K191E	LAMP2_uc004ess.3_Missense_Mutation_p.K191E|LAMP2_uc011mtz.1_Missense_Mutation_p.K80E|LAMP2_uc011mua.1_Missense_Mutation_p.K144E|LAMP2_uc010nqp.1_Missense_Mutation_p.K191E	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	191	Lumenal (Potential).|First lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						GTTTTGTCTTTATCACACAGG	0.408													0	0	0	0.011902	0	46	132										C	119581866	T	C	119581866	3	2	6	1	0	0	0	0	1	0	0	0	8618	1763	61	5	972	5	LAMP2	23	119581866	Missense_Mutation	SNP	T	TCGA-BT-A0YX-01A-11D-A10S-08	9886689	119581866	35688694	749	1462										
BCORL1	63035	broad.mit.edu	37	chrX	129185834	129185834	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	ccctatatgctccccttacaGaggaaaaagacgggtttgcc	9	12	0	2			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:129185834G>A	uc004evb.1	+	12	4811	c.4697_splice	c.e12-1	p.E1566_splice	BCORL1_uc004evc.1_Splice_Site_p.E402_splice	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TCCCCTTACAGAGGAAAAAGA	0.473													0	0	0	0.01441	0	78	292										A	129185834	G	A	129185834	5	1	6	1	0	0	0	0	0	0	1	0	1387	956	33	1	4964	1	BCORL1	23	129185834	Splice_Site	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	9603968	129185834	26084726	750	1463										
ZIC3	7547	broad.mit.edu	37	chrX	136649816	136649816	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gtcaaccacatccgagtgcaCacgggcgagaagcccttccc	10	16	1	1			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:136649816C>G	uc004fak.2	+	1	1471	c.966C>G	c.(964-966)CAC>CAG	p.H322Q		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	322	Nuclear localization signal.|C2H2-type 2; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					TCCGAGTGCACACGGGCGAGA	0.597													0	0	0	0.01441	0	55	186										G	136649816	C	G	136649816	3	3	6	1	0	0	0	0	1	0	0	0	17677	477	17	4	968	4	ZIC3	23	136649816	Missense_Mutation	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	7463982	136649816	18620744	751	1464										
MAGEA10	4109	broad.mit.edu	37	chrX	151303655	151303655	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tccttcatttgatacttgaaGagcagaaactgcaccaaatc	6	10	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:151303655G>C	uc004ffk.2	-	5	846	c.438C>G	c.(436-438)CTC>CTG	p.L146L	MAGEA10_uc004ffl.2_Silent_p.L146L	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	146	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GATACTTGAAGAGCAGAAACT	0.443													0	0	0	0.01441	0	67	183										C	151303655	G	C	151303655	2	2	6	1	0	0	0	0	0	0	0	1	9164	929	33	1		1	MAGEA10	23	151303655	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	14653839	151303655	3966905	752	1465										
PLXNB3	5365	broad.mit.edu	37	chrX	153040417	153040417	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	gactaccgcacctacgccgaGcgcgccttcttccctggcca	9	19	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:153040417G>A	uc004fii.2	+	24	4188	c.4014G>A	c.(4012-4014)GAG>GAA	p.E1338E	PLXNB3_uc010nuk.2_Silent_p.E1361E|PLXNB3_uc011mzd.1_Silent_p.E977E|PLXNB3_uc004fij.1_RNA|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1338	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTACGCCGAGCGCGCCTTCT	0.706													0	0	0	0.004656	0	24	86										A	153040417	G	A	153040417	2	1	6	1	0	0	0	0	0	0	0	1	12125	962	34	2		2	PLXNB3	23	153040417	Silent	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	1736762	153040417	2230143	753	1466										
FLNA	2316	broad.mit.edu	37	chrX	153577785	153577785	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	tggcctacgtaggccttgctCagccccaggcccttggccac	11	17	1	0			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:153577785C>T	uc004fkk.2	-	47	7950	c.7701G>A	c.(7699-7701)CTG>CTA	p.L2567L	FLNA_uc004fki.2_Silent_p.L607L|FLNA_uc011mzn.1_Silent_p.L700L|FLNA_uc010nuu.1_Silent_p.L2559L	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2567	Self-association site, tail.|Filamin 24.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGCCTTGCTCAGCCCCAGGC	0.657													0	0	0	0.01441	0	51	119										T	153577785	C	T	153577785	2	4	6	1	0	0	0	0	0	0	0	1	5933	813	29	1		1	FLNA	23	153577785	Silent	SNP	C	TCGA-BT-A0YX-01A-11D-A10S-08	537368	153577785	1692775	754	1467										
RPL10	6134	broad.mit.edu	37	chrX	153629109	153629109	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	aatttgaagacatggtggctGaaaagcggctcatcccagat	11	8	1	4			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:153629109G>A	uc004fkm.2	+	7	747	c.559G>A	c.(559-561)GAA>AAA	p.E187K	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Silent_p.L132L|RPL10_uc004fkn.1_Missense_Mutation_p.E187K|RPL10_uc004fkp.1_3'UTR|RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Intron	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	187					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATGGTGGCTGAAAAGCGGCT	0.527													0	0	0	0.008291	0	10	37										A	153629109	G	A	153629109	3	1	6	1	0	0	0	0	1	0	0	0	13554	1291	45	1	581	1	RPL10	23	153629109	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	51324	153629109	1641451	755	1468										
F8	2157	broad.mit.edu	37	chrX	154157864	154157864	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.636363636363636	476	6.06187447939218e-199	4.3459888747403	4.77726660457977	3.99436666228542	0.749546640523168	0.854746169017648	366	taatggagatctatttgcttGagggatgctatgactcctcg	11	7	1	3			TCGA-BT-A0YX-01A-11D-A10S-08	TCGA-BT-A0YX-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d61ccd8c-b798-46e0-aeed-f95b4f3ba4ff	b3b45e06-5837-4fe4-ba7b-ffb7f2fd535e	g.chrX:154157864G>C	uc004fmt.2	-	14	4372	c.4201C>G	c.(4201-4203)CAA>GAA	p.Q1401E		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1401	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CTATTTGCTTGAGGGATGCTA	0.443													0	0	0	0.01441	0	50	229										C	154157864	G	C	154157864	3	2	6	1	0	0	0	0	1	0	0	0	5350	1299	45	1	2934	1	F8	23	154157864	Missense_Mutation	SNP	G	TCGA-BT-A0YX-01A-11D-A10S-08	528755	154157864	1112696	756	1469										
TAS1R3	83756	broad.mit.edu	37	chr1	1268732	1268732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctacgactgtgtggactgcGaggcgggcagctaccggcaa	16	11	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:1268732G>A	uc010nyk.1	+	5	1573	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	525	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGTGGACTGCGAGGCGGGCAG	0.692													0	0	0	0.009096	0	4	11										A	1268732	G	A	1268732	3	1	7	1	0	0	0	0	1	0	0	0	15561	1059	37	1	1591	1	TAS1R3	1	1268732	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		1268732	247981889	1	1470										
CCDC27	148870	broad.mit.edu	37	chr1	3670737	3670737	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	catgtccaaaatggaacttcGaagggtcttccccacgcatc	8	13	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:3670737G>A	uc001akv.2	+	2	455	c.374G>A	c.(373-375)CGA>CAA	p.R125Q		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	125										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		ATGGAACTTCGAAGGGTCTTC	0.592													0	0	0	0.00632	0	27	139										A	3670737	G	A	3670737	3	1	7	1	0	0	0	0	1	0	0	0	2801	1058	37	1	380	1	CCDC27	1	3670737	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2402005	3670737	245579884	2	1471										
AJAP1	55966	broad.mit.edu	37	chr1	4772146	4772146	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttaggagtggacagccagcGcgggtcccggccccggtgtg	17	12	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:4772146G>A	uc001alm.1	+	2	597	c.216G>A	c.(214-216)GCG>GCA	p.A72A	AJAP1_uc001aln.2_Silent_p.A72A	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	72	Extracellular (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GACAGCCAGCGCGGGTCCCGG	0.632													0	0	0	0.000602	0	5	17										A	4772146	G	A	4772146	2	1	7	1	0	0	0	0	0	0	0	1	438	1074	38	2		2	AJAP1	1	4772146	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1101409	4772146	244478475	3	1472										
SPATA21	374955	broad.mit.edu	37	chr1	16735685	16735685	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagcttttggaggctctgctCttccggctcctgcctgcaga	11	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:16735685C>T	uc001ayn.2	-	7	1084	c.601G>A	c.(601-603)GAG>AAG	p.E201K	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Missense_Mutation_p.E178K	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	201	Potential.						calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		AGGCTCTGCTCTTCCGGCTCC	0.627													0	0	0	0.004672	0	3	36										T	16735685	C	T	16735685	3	4	7	1	0	0	0	0	1	0	0	0	15006	922	32	1	836	1	SPATA21	1	16735685	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	11963539	16735685	232514936	4	1473										
PADI2	11240	broad.mit.edu	37	chr1	17413062	17413062	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	catggatggagaccaggcctGagaagccctcgtcggggaaa	15	10	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:17413062G>C	uc001baf.2	-	7	870	c.788C>G	c.(787-789)TCA>TGA	p.S263*	PADI2_uc010ocm.1_Missense_Mutation_p.Q182E|PADI2_uc001bag.1_Nonsense_Mutation_p.S263*	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	263					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	GACCAGGCCTGAGAAGCCCTC	0.652													0	0	0	0.001984	0	6	33										C	17413062	G	C	17413062	4	2	7	1	0	0	0	0	0	1	0	0	11378	1294	45	1	1249	1	PADI2	1	17413062	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	677377	17413062	231837559	5	1474										
PQLC2	54896	broad.mit.edu	37	chr1	19653820	19653820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcgtgctgctcaaaaaccccGaggagggccagagcgagggc	16	12	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:19653820G>A	uc001bby.2	+	8	1070	c.718G>A	c.(718-720)GAG>AAG	p.E240K	PQLC2_uc001bbz.2_Missense_Mutation_p.E175K|PQLC2_uc001bca.2_Missense_Mutation_p.E240K|PQLC2_uc001bcb.2_Missense_Mutation_p.E129K|PQLC2_uc001bcc.2_Missense_Mutation_p.E129K	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	240	PQ-loop 2.|Extracellular (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CAAAAACCCCGAGGAGGGCCA	0.637													0	0	0	0.003163	0	14	41										A	19653820	G	A	19653820	3	1	7	1	0	0	0	0	1	0	0	0	12419	1059	37	1	740	1	PQLC2	1	19653820	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2240758	19653820	229596801	6	1475										
EIF4G3	8672	broad.mit.edu	37	chr1	21307591	21307591	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cactgggtacggcatgggcaGatggttaaccatcatgatgt	13	8	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:21307591G>A	uc001bec.2	-	4	416	c.160C>T	c.(160-162)CTG>TTG	p.L54L	EIF4G3_uc010odj.1_Silent_p.L54L|EIF4G3_uc009vpz.2_Silent_p.L54L|EIF4G3_uc001bed.2_Silent_p.L54L|EIF4G3_uc001bef.2_Silent_p.L54L|EIF4G3_uc001bee.2_Silent_p.L61L|EIF4G3_uc001beg.2_Silent_p.L54L|EIF4G3_uc010odk.1_Silent_p.L54L|EIF4G3_uc001beh.2_Silent_p.L65L	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	54					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GGCATGGGCAGATGGTTAACC	0.517													0	0	0	0.001855	0	13	45										A	21307591	G	A	21307591	2	1	7	1	0	0	0	0	0	0	0	1	5038	933	33	1		1	EIF4G3	1	21307591	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1653771	21307591	227943030	7	1476										
ARID1A	8289	broad.mit.edu	37	chr1	27087921	27087921	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtggccagtcggacagcatCatgcatccttccatgaacca	9	13	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:27087921C>T	uc001bmv.1	+	6	2581	c.2208C>T	c.(2206-2208)ATC>ATT	p.I736I	ARID1A_uc001bmt.1_Silent_p.I736I|ARID1A_uc001bmu.1_Silent_p.I736I|ARID1A_uc001bmw.1_Silent_p.I353I	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	736					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CGGACAGCATCATGCATCCTT	0.547			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.004007	0	13	40										T	27087921	C	T	27087921	2	4	7	1	0	0	0	0	0	0	0	1	913	816	29	1		1	ARID1A	1	27087921	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5780330	27087921	222162700	8	1477										
WASF2	10163	broad.mit.edu	37	chr1	27744801	27744801	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagattgttgagagggggagGagtatcacaggtattgtatg	16	2	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:27744801G>A	uc001bof.1	-	4	604	c.388C>T	c.(388-390)CCT>TCT	p.P130S	WASF2_uc010ofl.1_Missense_Mutation_p.P130S	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	130					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		AGAGGGGGAGGAGTATCACAG	0.423													0	0	0	0.004482	0	9	28										A	27744801	G	A	27744801	3	1	7	1	0	0	0	0	1	0	0	0	17250	1174	41	1	1132	1	WASF2	1	27744801	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	656880	27744801	221505820	9	1478										
OPRD1	4985	broad.mit.edu	37	chr1	29185686	29185686	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgttgaccgctacatcgctGtctgccaccctgtcaaggcc	10	15	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:29185686G>T	uc001brf.1	+	2	690	c.448G>T	c.(448-450)GTC>TTC	p.V150F		NM_000911	NP_000902	P41143	OPRD_HUMAN	opioid receptor, delta 1	150	Cytoplasmic (Potential).				immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	CTACATCGCTGTCTGCCACCC	0.577													1	0	4.68919e-08	0.008291	4.93976e-08	10	40										T	29185686	G	T	29185686	3	4	7	1	0	0	0	0	1	0	0	0	10884	1377	48	4	454	4	OPRD1	1	29185686	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1440885	29185686	220064935	10	1479										
MACF1	23499	broad.mit.edu	37	chr1	39797292	39797292	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acctggaagaggcttttcatCaaggcctcatttctgcatgg	10	10	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:39797292C>G	uc010oiu.1	+	1	483	c.352C>G	c.(352-354)CAA>GAA	p.Q118E	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1683	Plectin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGCTTTTCATCAAGGCCTCAT	0.413													0	0	0	0.000602	0	5	551										G	39797292	C	G	39797292	3	3	7	1	0	0	0	0	1	0	0	0	9144	827	29	1	5123	1	MACF1	1	39797292	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10611606	39797292	209453329	11	1480										
MACF1	23499	broad.mit.edu	37	chr1	39827347	39827347	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cacatttcttccaacagatcCaggtgaggatatatctgcca	7	11	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:39827347C>T	uc010oiu.1	+	13	8220	c.8089C>T	c.(8089-8091)CAG>TAG	p.Q2697*	MACF1_uc010ois.1_Nonsense_Mutation_p.Q2195*|MACF1_uc001cda.1_Nonsense_Mutation_p.Q2103*|MACF1_uc001cdc.1_Nonsense_Mutation_p.Q1282*|MACF1_uc001cdb.1_Nonsense_Mutation_p.Q1282*	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4262	LRR 15.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCAACAGATCCAGGTGAGGAT	0.358													0	0	0	0.00361	0	299	46										T	39827347	C	T	39827347	4	4	7	1	0	0	0	0	0	1	0	0	9144	595	21	2	12908	2	MACF1	1	39827347	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	30055	39827347	209423274	12	1481										
PABPC4	8761	broad.mit.edu	37	chr1	40038094	40038094	+	Frame_Shift_Del	DEL	A	A	-													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagtatgtttccaaaagcagAaaaagtatcataaagtgcct							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:40038094delA	uc010oiv.1	-	2	1256	c.358delT	c.(358-360)TCTfs	p.S120fs	PABPC4_uc001cdl.2_Frame_Shift_Del_p.S120fs|PABPC4_uc001cdm.2_Frame_Shift_Del_p.S120fs	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	120	RRM 2.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CCAAAAGCAGAAAAAGTATCA	0.343																		12	516	---	---								-	40038094	A	-	40038094	7	5	7	1	0	1	0	1	0	0	0	0	11366	246	9	0	1680	0	PABPC4	1	40038094	Frame_Shift_Del	DEL	A	TCGA-BT-A20J-01A-11D-A14W-08	210747	40038094	209212527	13	1482										
TRIT1	54802	broad.mit.edu	37	chr1	40310268	40310268	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcttcccacttcgagacatCagatacctctaagccataga	5	14	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:40310268C>T	uc010oiz.1	-	9	1065	c.1051G>A	c.(1051-1053)GAT>AAT	p.D351N	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_Missense_Mutation_p.D47N|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_Missense_Mutation_p.D105N|TRIT1_uc001ceh.3_Missense_Mutation_p.D105N|TRIT1_uc009vvv.2_Missense_Mutation_p.D184N|TRIT1_uc001cei.3_Missense_Mutation_p.D105N|TRIT1_uc001ceq.2_Missense_Mutation_p.D47N|TRIT1_uc001cek.2_Missense_Mutation_p.D47N|TRIT1_uc009vvx.2_RNA|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Missense_Mutation_p.D269N|TRIT1_uc001cen.2_Missense_Mutation_p.D105N|TRIT1_uc001ceo.2_Missense_Mutation_p.D105N|TRIT1_uc001cep.2_Missense_Mutation_p.D105N	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	351					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTCGAGACATCAGATACCTCT	0.433													0	0	0	0.001984	0	6	265										T	40310268	C	T	40310268	3	4	7	1	0	0	0	0	1	0	0	0	16557	826	29	1	364	1	TRIT1	1	40310268	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	272174	40310268	208940353	14	1483										
CCDC30	728621	broad.mit.edu	37	chr1	43011099	43011099	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtcttgaagctttcacaaGaatttgcacaattaaatcat	6	7	3	2	rs12746482		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:43011099G>C	uc009vwk.1	+	4	384	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	CCDC30_uc001chm.2_5'UTR|CCDC30_uc001chn.2_Intron|CCDC30_uc010oju.1_RNA|CCDC30_uc001chp.2_Intron	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	92	Potential.										0						GCTTTCACAAGAATTTGCACA	0.289													0	0	0	0.000602	0	5	412										C	43011099	G	C	43011099	3	2	7	1	0	0	0	0	1	0	0	0	2805	943	33	1	284	1	CCDC30	1	43011099	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2700831	43011099	206239522	15	1484										
ELAVL4	1996	broad.mit.edu	37	chr1	50666507	50666507	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtctggaccagtccccccttCtgcttgtccccccaggttct	8	18	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:50666507C>T	uc001csb.2	+	7	1068	c.800C>T	c.(799-801)TCT>TTT	p.S267F	ELAVL4_uc001cry.3_Intron|ELAVL4_uc001crz.3_Intron|ELAVL4_uc001csa.3_Intron|ELAVL4_uc001csc.3_Intron|ELAVL4_uc010omz.1_Intron	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	267					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GTCCCCCCTTCTGCTTGTCCC	0.522													0	0	0	0.00499	0	16	60										T	50666507	C	T	50666507	3	4	7	1	0	0	0	0	1	0	0	0	5052	913	32	1	925	1	ELAVL4	1	50666507	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7655408	50666507	198584114	16	1485										
TTC39A	22996	broad.mit.edu	37	chr1	51778567	51778567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaggtcatcatggcctgcatCtccaggatggtggcatatgt	12	9	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:51778567C>G	uc001csl.2	-	3	303	c.198G>C	c.(196-198)GAG>GAC	p.E66D	TTC39A_uc001csk.2_Missense_Mutation_p.E66D|TTC39A_uc010ond.1_Missense_Mutation_p.E38D|TTC39A_uc010one.1_Missense_Mutation_p.E65D|TTC39A_uc010onf.1_Missense_Mutation_p.E69D|TTC39A_uc001csn.2_Missense_Mutation_p.E65D|TTC39A_uc001cso.1_Missense_Mutation_p.E62D|TTC39A_uc009vyy.1_Missense_Mutation_p.E38D	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	66							binding			skin(1)	1						TGGCCTGCATCTCCAGGATGG	0.542													0	0	0	0.010818	0	32	136										G	51778567	C	G	51778567	3	3	7	1	0	0	0	0	1	0	0	0	16704	912	32	1	1602	1	TTC39A	1	51778567	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1112060	51778567	197472054	17	1486										
FAM73A	374986	broad.mit.edu	37	chr1	78249010	78249010	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taagagtgtttgatcttcctCtgacttggtactattctctc	7	9	3	3	rs146841294		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:78249010C>G	uc001dhx.2	+	2	201	c.169C>G	c.(169-171)CTG>GTG	p.L57V	FAM73A_uc010ork.1_Missense_Mutation_p.L57V|FAM73A_uc010orl.1_Intron	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	57						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		TGATCTTCCTCTGACTTGGTA	0.358													0	0	0	0.002299	0	21	325										G	78249010	C	G	78249010	3	3	7	1	0	0	0	0	1	0	0	0	5617	912	32	1	175	1	FAM73A	1	78249010	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	26470443	78249010	171001611	18	1487										
LPHN2	23266	broad.mit.edu	37	chr1	82456581	82456581	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttatacaagcatgcccaatCttagagactctccctatccg	5	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:82456581C>G	uc001dit.3	+	21	4145	c.3964C>G	c.(3964-3966)CTT>GTT	p.L1322V	LPHN2_uc001dis.2_Missense_Mutation_p.L302V|LPHN2_uc001diu.2_Missense_Mutation_p.L1322V|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.L949V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1378	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CATGCCCAATCTTAGAGACTC	0.473													0	0	0	0.004672	0	3	88										G	82456581	C	G	82456581	3	3	7	1	0	0	0	0	1	0	0	0	8916	913	32	1	4038	1	LPHN2	1	82456581	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4207571	82456581	166794040	19	1488										
CLCA1	1179	broad.mit.edu	37	chr1	86954697	86954697	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtgattaggaagaaatatCcaactgatggatctgaaatt	10	4	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:86954697C>T	uc001dlt.2	+	8	1330	c.1201C>T	c.(1201-1203)CCA>TCA	p.P401S	CLCA1_uc001dls.1_Missense_Mutation_p.P340S	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	401	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GAAGAAATATCCAACTGATGG	0.433													0	0	0	0.011902	0	43	50										T	86954697	C	T	86954697	3	4	7	1	0	0	0	0	1	0	0	0	3457	855	30	1	1231	1	CLCA1	1	86954697	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4498116	86954697	162295924	20	1489										
CLCA1	1179	broad.mit.edu	37	chr1	86961284	86961284	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaaagtgcgggctctgggagGagttaacgcagccagacgga	16	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:86961284G>A	uc001dlt.2	+	12	2168	c.2039G>A	c.(2038-2040)GGA>GAA	p.G680E		NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	680					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCTCTGGGAGGAGTTAACGCA	0.463													0	0	0	0.008291	0	9	74										A	86961284	G	A	86961284	3	1	7	1	0	0	0	0	1	0	0	0	3457	1174	41	1	2085	1	CLCA1	1	86961284	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6587	86961284	162289337	21	1490										
BRDT	676	broad.mit.edu	37	chr1	92446495	92446495	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttggtctaaaatctgaagatGaagataatgctaaacctatg	8	5	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:92446495G>A	uc001dok.3	+	10	1859	c.1510G>A	c.(1510-1512)GAA>AAA	p.E504K	BRDT_uc001dol.3_Missense_Mutation_p.E504K|BRDT_uc010osz.1_Missense_Mutation_p.E508K|BRDT_uc009wdf.2_Missense_Mutation_p.E431K|BRDT_uc010ota.1_Missense_Mutation_p.E458K|BRDT_uc010otb.1_Missense_Mutation_p.E458K|BRDT_uc001dom.3_Missense_Mutation_p.E504K	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		ATCTGAAGATGAAGATAATGC	0.333													0	0	0	0.006214	0	9	82										A	92446495	G	A	92446495	3	1	7	1	0	0	0	0	1	0	0	0	1508	1291	45	1	1544	1	BRDT	1	92446495	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5485211	92446495	156804126	22	1491										
VANGL1	81839	broad.mit.edu	37	chr1	116206759	116206759	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatatgcagtctcccttgtgGatgccctcctcttcatccat	6	14	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:116206759G>C	uc001efv.1	+	4	953	c.682G>C	c.(682-684)GAT>CAT	p.D228H	VANGL1_uc009wgy.1_Missense_Mutation_p.D226H|VANGL1_uc001efw.1_Missense_Mutation_p.D228H	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	228	Helical; Name=4; (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CTCCCTTGTGGATGCCCTCCT	0.557													0	0	0	0.010504	0	18	67										C	116206759	G	C	116206759	3	2	7	1	0	0	0	0	1	0	0	0	17116	1174	41	1	692	1	VANGL1	1	116206759	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	23760264	116206759	133043862	23	1492										
MTMR11	10903	broad.mit.edu	37	chr1	149905798	149905798	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgctctcctgacctcactgtCcagaattcggttagggaccc	9	14	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:149905798C>G	uc001etl.3	-	8	972	c.721G>C	c.(721-723)GAC>CAC	p.D241H	MTMR11_uc001etm.1_Missense_Mutation_p.D169H|MTMR11_uc010pbm.1_Missense_Mutation_p.D213H|MTMR11_uc010pbn.1_Missense_Mutation_p.D83H	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	241	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACCTCACTGTCCAGAATTCGG	0.493													0	0	0	0.00361	0	55	194										G	149905798	C	G	149905798	3	3	7	1	0	0	0	0	1	0	0	0	9940	855	30	1	1487	1	MTMR11	1	149905798	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	33699039	149905798	99344823	24	1493										
OTUD7B	56957	broad.mit.edu	37	chr1	149916075	149916075	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtcctggtgggggtagggtCgcccaggagggcactgtctg	19	9	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:149916075C>T	uc001etn.2	-	12	2569	c.2213G>A	c.(2212-2214)CGA>CAA	p.R738Q		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	738					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			GGGGTAGGGTCGCCCAGGAGG	0.642													0	0	0	0.00278	0	22	58										T	149916075	C	T	149916075	3	4	7	1	0	0	0	0	1	0	0	0	11319	884	31	1	322	1	OTUD7B	1	149916075	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10277	149916075	99334546	25	1494										
ANP32E	81611	broad.mit.edu	37	chr1	150193030	150193030	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctccatcgtcttcagcatctCgtttcctcttctcccctcga	4	18	5	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:150193030C>T	uc001etw.2	-	7	1140	c.770G>A	c.(769-771)CGA>CAA	p.R257Q	ANP32E_uc010pbt.1_RNA|ANP32E_uc010pbu.1_Missense_Mutation_p.R209Q|ANP32E_uc010pbv.1_Missense_Mutation_p.R216Q|ANP32E_uc001etv.3_Missense_Mutation_p.R256Q	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	257	Asp/Glu-rich (highly acidic).					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCAGCATCTCGTTTCCTCTT	0.383													0	0	0	0.00874	0	38	317										T	150193030	C	T	150193030	3	4	7	1	0	0	0	0	1	0	0	0	709	884	31	1	40	1	ANP32E	1	150193030	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	276955	150193030	99057591	26	1495										
C1orf51	148523	broad.mit.edu	37	chr1	150259343	150259343	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccatcctccagttgctgctGatgctcatcttctcaacctc	6	16	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:150259343G>A	uc001euh.2	+	6	1271	c.1135G>A	c.(1135-1137)GAT>AAT	p.D379N	C1orf51_uc001eui.2_Missense_Mutation_p.D291N|C1orf51_uc001euj.2_Missense_Mutation_p.D379N	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	379											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGTTGCTGCTGATGCTCATCT	0.458													0	0	0	0.002299	0	20	74										A	150259343	G	A	150259343	3	1	7	1	0	0	0	0	1	0	0	0	2043	1290	45	1	1153	1	C1orf51	1	150259343	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	66313	150259343	98991278	27	1496										
THEM4	117145	broad.mit.edu	37	chr1	151861806	151861806	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcatcaaagcttctggtgaaGagctgggcctgtgacatttg	12	8	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:151861806G>A	uc001ezj.1	-	3	509	c.330C>T	c.(328-330)CTC>CTT	p.L110L	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	110					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTCTGGTGAAGAGCTGGGCCT	0.438													0	0	0	0.006214	0	10	116										A	151861806	G	A	151861806	2	1	7	1	0	0	0	0	0	0	0	1	15855	929	33	1		1	THEM4	1	151861806	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1602463	151861806	97388815	28	1497										
HRNR	388697	broad.mit.edu	37	chr1	152192570	152192570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaccatagctggaagatgaaCctgcactagatccttgtcgt	10	10	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:152192570C>T	uc001ezt.1	-	3	1611	c.1535G>A	c.(1534-1536)GGT>GAT	p.G512D		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	512	5.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAAGATGAACCTGCACTAGA	0.572													0	0	0	0.00361	0	120	236										T	152192570	C	T	152192570	3	4	7	1	0	0	0	0	1	0	0	0	7359	507	18	2	7021	2	HRNR	1	152192570	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	330764	152192570	97058051	29	1498										
DENND4B	9909	broad.mit.edu	37	chr1	153906268	153906268	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggagcggctcctcccctgtCaggctcaggtctgagagact	14	13	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:153906268C>G	uc001fdd.1	-	20	3422	c.3021G>C	c.(3019-3021)CTG>CTC	p.L1007L	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1007										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCTCCCCTGTCAGGCTCAGGT	0.647													0	0	0	0.00308	0	8	13										G	153906268	C	G	153906268	2	3	7	1	0	0	0	0	0	0	0	1	4434	813	29	1		1	DENND4B	1	153906268	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1713698	153906268	95344353	30	1499										
UBAP2L	9898	broad.mit.edu	37	chr1	154223614	154223614	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atggaggtgttccttcaggaGaagtcacctgcagtggctac	13	9	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:154223614G>C	uc001fep.3	+	13	1478	c.1311G>C	c.(1309-1311)GAG>GAC	p.E437D	UBAP2L_uc009wot.2_Missense_Mutation_p.E437D|UBAP2L_uc010pek.1_Missense_Mutation_p.E429D|UBAP2L_uc010pel.1_Missense_Mutation_p.E447D|UBAP2L_uc010pen.1_Missense_Mutation_p.E351D	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	437					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCCTTCAGGAGAAGTCACCTG	0.532													0	0	0	0.004007	0	15	128										C	154223614	G	C	154223614	3	2	7	1	0	0	0	0	1	0	0	0	16835	933	33	1	1357	1	UBAP2L	1	154223614	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	317346	154223614	95027007	31	1500										
ASH1L	55870	broad.mit.edu	37	chr1	155319163	155319163	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgtcagcatcaaaagcttcCactgtcttatagtaaccagt	6	10	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:155319163C>T	uc009wqq.2	-	19	8004	c.7524G>A	c.(7522-7524)GTG>GTA	p.V2508V	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Silent_p.V2503V|MIR555_hsa-mir-555|MI0003561_5'Flank	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2508	Bromo.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAAAAGCTTCCACTGTCTTAT	0.383													0	0	0	0.002299	0	24	58										T	155319163	C	T	155319163	2	4	7	1	0	0	0	0	0	0	0	1	1041	581	21	2		2	ASH1L	1	155319163	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1095549	155319163	93931458	32	1501										
KIAA0907	22889	broad.mit.edu	37	chr1	155896471	155896471	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctccccaaaacatacccctGactggaagggaggcttctgg	10	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:155896471G>A	uc001fmi.1	-	6	701	c.677C>T	c.(676-678)TCA>TTA	p.S226L	KIAA0907_uc001fmj.1_Missense_Mutation_p.S226L|KIAA0907_uc009wrk.1_Intron|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.S226L|KIAA0907_uc001fmm.2_Intron|SCARNA4_uc001fmn.1_5'Flank|KIAA0907_uc001fmo.2_Missense_Mutation_p.S226L	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	226											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			ACATACCCCTGACTGGAAGGG	0.363													0	0	0	0.008361	0	23	59										A	155896471	G	A	155896471	3	1	7	1	0	0	0	0	1	0	0	0	8199	1294	45	1	1203	1	KIAA0907	1	155896471	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	577308	155896471	93354150	33	1502										
MEF2D	4209	broad.mit.edu	37	chr1	156446809	156446809	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagacacccacttaccaagtGatgcattaacccctttcctg	5	15	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:156446809G>A	uc001fpc.2	-	7	1240	c.850C>T	c.(850-852)CAC>TAC	p.H284Y	MEF2D_uc001fpb.2_Missense_Mutation_p.H284Y|MEF2D_uc001fpd.2_Missense_Mutation_p.H284Y|MEF2D_uc001fpe.1_Missense_Mutation_p.H284Y|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	284					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTTACCAAGTGATGCATTAAC	0.607													0	0	0	0.001984	0	7	61										A	156446809	G	A	156446809	3	1	7	1	0	0	0	0	1	0	0	0	9458	1290	45	1	739	1	MEF2D	1	156446809	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	550338	156446809	92803812	34	1503										
CD1A	909	broad.mit.edu	37	chr1	158226807	158226807	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggcagctgacctgtcctgtcGggtgaagcacagcagtctag	14	11	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:158226807G>A	uc001frt.2	+	4	1369	c.836G>A	c.(835-837)CGG>CAG	p.R279Q		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	279	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CTGTCCTGTCGGGTGAAGCAC	0.612													0	0	0	0.001368	0	13	50										A	158226807	G	A	158226807	3	1	7	1	0	0	0	0	1	0	0	0	2974	1116	39	2	850	2	CD1A	1	158226807	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1779998	158226807	91023814	35	1504										
COPA	1314	broad.mit.edu	37	chr1	160282929	160282929	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taggacccagaaacgatcatGgtctctgcggaaagtctgaa	11	9	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:160282929G>T	uc009wti.2	-	10	1265	c.871C>A	c.(871-873)CAT>AAT	p.H291N	COPA_uc001fvv.3_Missense_Mutation_p.H291N|COPA_uc009wtj.1_Missense_Mutation_p.H237N	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	291					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AAACGATCATGGTCTCTGCGG	0.403													1	0	6.40141e-05	0.010729	6.5925e-05	11	53										T	160282929	G	T	160282929	3	4	7	1	0	0	0	0	1	0	0	0	3727	1348	47	4	2926	4	COPA	1	160282929	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2056122	160282929	88967692	36	1505										
FCGR3B	2215	broad.mit.edu	37	chr1	161600882	161600882	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gttgggaggagcagctgccaCatgatgccacactggagtgg	16	9	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:161600882C>T	uc009wul.2	-	1	277	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	1					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCAGCTGCCACATGATGCCAC	0.542													0	0	0	0.004482	0	7	27										T	161600882	C	T	161600882	3	4	7	1	0	0	0	0	1	0	0	0	5785	478	17	2	718	2	FCGR3B	1	161600882	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1317953	161600882	87649739	37	1506										
ZBTB37	84614	broad.mit.edu	37	chr1	173839952	173839952	+	Nonsense_Mutation	SNP	C	C	T													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgaggagtccaccagccctCagatcattgaaccaagttct							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:173839952C>T	uc009wwp.1	+	3	865	c.589C>T	c.(589-591)CAG>TAG	p.Q197*	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|ZBTB37_uc001gjp.1_Nonsense_Mutation_p.Q197*|ZBTB37_uc001gjq.3_Nonsense_Mutation_p.Q197*|ZBTB37_uc001gjr.2_Nonsense_Mutation_p.Q197*	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACCAGCCCTCAGATCATTGA	0.552													0	0	0	0.00245	0	12	43										T	173839952	C	T	173839952	4	4	7	1	0	0	0	0	0	1	0	0	17535	827	29	1	591	1	ZBTB37	1	173839952	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	12239070	173839952	75410669	38	1507	10	2								
ZBTB37	84614	broad.mit.edu	37	chr1	173839957	173839957	+	Silent	SNP	C	C	T													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagtccaccagccctcagatCattgaaccaagttctgatgt							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:173839957C>T	uc009wwp.1	+	3	870	c.594C>T	c.(592-594)ATC>ATT	p.I198I	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|ZBTB37_uc001gjp.1_Silent_p.I198I|ZBTB37_uc001gjq.3_Silent_p.I198I|ZBTB37_uc001gjr.2_Silent_p.I198I	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCCTCAGATCATTGAACCAA	0.557													0	0	0	0.001855	0	11	40										T	173839957	C	T	173839957	2	4	7	1	0	0	0	0	0	0	0	1	17535	816	29	1		1	ZBTB37	1	173839957	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5	173839957	75410664	39	1508	10	2								
XPR1	9213	broad.mit.edu	37	chr1	180775291	180775291	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	attggcgagtggctcacgtaGaggtggccccattttataca	12	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:180775291G>C	uc001goi.2	+	5	733	c.541G>C	c.(541-543)GAG>CAG	p.E181Q	XPR1_uc009wxm.2_Missense_Mutation_p.E181Q|XPR1_uc009wxn.2_Missense_Mutation_p.E181Q	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	181	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GGCTCACGTAGAGGTGGCCCC	0.398													0	0	0	0.004482	0	9	71										C	180775291	G	C	180775291	3	2	7	1	0	0	0	0	1	0	0	0	17448	943	33	1	559	1	XPR1	1	180775291	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6935334	180775291	68475330	40	1509										
ASPM	259266	broad.mit.edu	37	chr1	197112229	197112229	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taaaataggattaactgactCtgattctagatcctgattta	6	6	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:197112229C>G	uc001gtu.2	-	3	1410	c.1153G>C	c.(1153-1155)GAG>CAG	p.E385Q	ASPM_uc001gtv.2_Missense_Mutation_p.E385Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	385					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTAACTGACTCTGATTCTAGA	0.289													0	0	0	0.001855	0	11	58										G	197112229	C	G	197112229	3	3	7	1	0	0	0	0	1	0	0	0	1056	922	32	1	9384	1	ASPM	1	197112229	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	16336938	197112229	52138392	41	1510										
RAB7L1	8934	broad.mit.edu	37	chr1	205741642	205741642	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acctgcaatatcccacagctGaagccgcactatctcgtagt	7	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:205741642G>C	uc001hdf.3	-	3	518	c.178C>G	c.(178-180)CAG>GAG	p.Q60E	RAB7L1_uc009xbp.2_5'UTR|RAB7L1_uc001hde.3_Missense_Mutation_p.Q60E|RAB7L1_uc010prr.1_Intron|RAB7L1_uc009xbq.2_Intron	NM_003929	NP_003920	O14966	RAB7L_HUMAN	RAB7, member RAS oncogene family-like 1 isoform	60					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TCCCACAGCTGAAGCCGCACT	0.383													0	0	0	0.00361	0	92	102										C	205741642	G	C	205741642	3	2	7	1	0	0	0	0	1	0	0	0	12955	1299	45	1	449	1	RAB7L1	1	205741642	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8629413	205741642	43508979	42	1511										
USH2A	7399	broad.mit.edu	37	chr1	216243607	216243607	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atccatttaagctgcggactCttgagggagttggcacactt	11	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:216243607C>T	uc001hku.1	-	30	6272	c.5885G>A	c.(5884-5886)AGA>AAA	p.R1962K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1962	Extracellular (Potential).|Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCTGCGGACTCTTGAGGGAGT	0.428										HNSCC(13;0.011)			0	0	0	0.001168	0	6	44										T	216243607	C	T	216243607	3	4	7	1	0	0	0	0	1	0	0	0	17033	913	32	1	9895	1	USH2A	1	216243607	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10501965	216243607	33007014	43	1512										
TLR5	7100	broad.mit.edu	37	chr1	223286345	223286345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaccggccatgagcaccactCctaggagaaggtccaggtgg	14	12	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:223286345C>T	uc001hnv.1	-	4	475	c.29G>A	c.(28-30)GGA>GAA	p.G10E	TLR5_uc001hnw.1_Missense_Mutation_p.G10E	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	10					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		GAGCACCACTCCTAGGAGAAG	0.517													0	0	0	0.009096	0	4	29										T	223286345	C	T	223286345	3	4	7	1	0	0	0	0	1	0	0	0	15951	855	30	1	2551	1	TLR5	1	223286345	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7042738	223286345	25964276	44	1513										
ACTA1	58	broad.mit.edu	37	chr1	229568092	229568092	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagatcgcggcccgccaggtCcaggcgcatgatggcgtgcg	17	13	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:229568092C>T	uc001htm.2	-	4	646	c.541G>A	c.(541-543)GAC>AAC	p.D181N		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	181			D -> H (in NEM3).|D -> G (in NEM3).|D -> N (in NEM3).		muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	CCCGCCAGGTCCAGGCGCATG	0.577													0	0	0	0.000602	0	5	35										T	229568092	C	T	229568092	3	4	7	1	0	0	0	0	1	0	0	0	191	855	30	1	608	1	ACTA1	1	229568092	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6281747	229568092	19682529	45	1514										
ERO1LB	56605	broad.mit.edu	37	chr1	236390014	236390014	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtcccgatataagcttataGaagactcttttctccagaca	6	10	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:236390014G>C	uc001hxt.2	-	11	994	c.738C>G	c.(736-738)TTC>TTG	p.F246L		NM_019891	NP_063944	Q86YB8	ERO1B_HUMAN	endoplasmic reticulum oxidoreductin 1-Lbeta	246					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TAAGCTTATAGAAGACTCTTT	0.318													0	0	0	0.010504	0	21	59										C	236390014	G	C	236390014	3	2	7	1	0	0	0	0	1	0	0	0	5240	933	33	1	689	1	ERO1LB	1	236390014	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6821922	236390014	12860607	46	1515										
ZNF695	57116	broad.mit.edu	37	chr1	247150452	247150452	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttctctccagtatgaattctCttatgattagtaagatatga	6	6	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr1:247150452C>G	uc009xgu.2	-	4	1510	c.1365G>C	c.(1363-1365)AAG>AAC	p.K455N	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	455	C2H2-type 11.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TATGAATTCTCTTATGATTAG	0.373													0	0	0	0.008361	0	30	22										G	247150452	C	G	247150452	3	3	7	1	0	0	0	0	1	0	0	0	18095	912	32	1	186	1	ZNF695	1	247150452	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10760438	247150452	2100169	47	1516										
GRHL1	29841	broad.mit.edu	37	chr2	10126392	10126392	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caccgggcctactgccagatCaaggtcttctgtgacaaggt	11	12	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:10126392C>T	uc002raa.2	+	9	1422	c.1251C>T	c.(1249-1251)ATC>ATT	p.I417I	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Silent_p.I228I|GRHL1_uc010yjb.1_Silent_p.I266I	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	417					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		ACTGCCAGATCAAGGTCTTCT	0.468													0	0	0	0.010771	0	41	219										T	10126392	C	T	10126392	2	4	7	1	0	0	0	0	0	0	0	1	6763	816	29	1		1	GRHL1	2	10126392	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08		10126392	233072981	48	1517										
ROCK2	9475	broad.mit.edu	37	chr2	11427791	11427791	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acatacttacatctatttaaGaaattatctatgttcttgtt	3	6	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:11427791G>C	uc002rbd.1	-	2	662	c.213C>G	c.(211-213)TTC>TTG	p.F71L		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	71					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		ATCTATTTAAGAAATTATCTA	0.264													0	0	0	0.004672	0	3	13										C	11427791	G	C	11427791	3	2	7	1	0	0	0	0	1	0	0	0	13518	933	33	1	4081	1	ROCK2	2	11427791	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1301399	11427791	231771582	49	1518										
ATAD2B	54454	broad.mit.edu	37	chr2	24011422	24011422	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggagccattgatgcctgattGagaatcaattcttgaaaaaa	9	6	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:24011422G>C	uc002rek.3	-	20	3030	c.2736C>G	c.(2734-2736)CTC>CTG	p.L912L	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Silent_p.L157L|ATAD2B_uc002rej.3_Silent_p.L80L	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	912							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGCCTGATTGAGAATCAATT	0.358													0	0	0	0.009096	0	4	44										C	24011422	G	C	24011422	2	2	7	1	0	0	0	0	0	0	0	1	1072	1277	45	1		1	ATAD2B	2	24011422	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	12583631	24011422	219187951	50	1519										
CAPN13	92291	broad.mit.edu	37	chr2	30976031	30976031	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcgctacatataaacatggcGatgaatttctgttggaaatc	8	7	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:30976031G>A	uc002rnn.2	-	10	1151	c.975C>T	c.(973-975)ATC>ATT	p.I325I	CAPN13_uc002rnp.1_Silent_p.I325I	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	325	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TAAACATGGCGATGAATTTCT	0.438													0	0	0	0.000602	0	5	113										A	30976031	G	A	30976031	2	1	7	1	0	0	0	0	0	0	0	1	2626	1048	37	1		1	CAPN13	2	30976031	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6964609	30976031	212223342	51	1520										
LTBP1	4052	broad.mit.edu	37	chr2	33412110	33412110	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtcatccattcaacacatacCttgcctctgaccgtgactag	6	14	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:33412110C>T	uc002ros.2	+	6	1389	c.1389C>T	c.(1387-1389)ACC>ACT	p.T463T	LTBP1_uc002rot.2_Silent_p.T137T|LTBP1_uc002rou.2_Silent_p.T137T|LTBP1_uc002rov.2_Silent_p.T137T|LTBP1_uc010ymz.1_Silent_p.T137T|LTBP1_uc010yna.1_Silent_p.T137T	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	463					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAACACATACCTTGCCTCTGA	0.517													0	0	0	0.003163	0	13	31										T	33412110	C	T	33412110	2	4	7	1	0	0	0	0	0	0	0	1	9073	668	24	2		2	LTBP1	2	33412110	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2436079	33412110	209787263	52	1521										
VIT	5212	broad.mit.edu	37	chr2	37000939	37000939	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caaatgtccttacagatctcTggtccactgccacctacaca	5	15	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:37000939T>C	uc002rpl.2	+	8	906	c.685T>C	c.(685-687)TGG>CGG	p.W229R	VIT_uc010ynf.1_Missense_Mutation_p.W158R|VIT_uc002rpm.2_Missense_Mutation_p.W222R|VIT_uc010ezv.2_Missense_Mutation_p.W222R|VIT_uc010ezw.2_Missense_Mutation_p.W222R	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	229						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				TACAGATCTCTGGTCCACTGC	0.328													0	0	0	0.00308	0	8	7										C	37000939	T	C	37000939	3	2	7	1	0	0	0	0	1	0	0	0	17168	1580	55	5	836	5	VIT	2	37000939	Missense_Mutation	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	3588829	37000939	206198434	53	1522										
HEATR5B	54497	broad.mit.edu	37	chr2	37283642	37283642	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agggccacagaagcatcaatGactgagactccgagagggag	14	9	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:37283642G>C	uc002rpp.1	-	16	2436	c.2340C>G	c.(2338-2340)GTC>GTG	p.V780V		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	780							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				AAGCATCAATGACTGAGACTC	0.433													0	0	0	0.00333	0	23	83										C	37283642	G	C	37283642	2	2	7	1	0	0	0	0	0	0	0	1	7032	1277	45	1		1	HEATR5B	2	37283642	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	282703	37283642	205915731	54	1523										
HEATR5B	54497	broad.mit.edu	37	chr2	37284473	37284473	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttattacctggtcttcaattGatttatgatcagtttcctga	6	7	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:37284473G>A	uc002rpp.1	-	15	2306	c.2210C>T	c.(2209-2211)TCA>TTA	p.S737L		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	737							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GTCTTCAATTGATTTATGATC	0.358													0	0	0	0.000602	0	4	36										A	37284473	G	A	37284473	3	1	7	1	0	0	0	0	1	0	0	0	7032	1294	45	1	4093	1	HEATR5B	2	37284473	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	831	37284473	205914900	55	1524										
SOS1	6654	broad.mit.edu	37	chr2	39234309	39234309	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caccacagctactctttcttCtaaattttcagtttctacaa	2	12	5	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:39234309C>T	uc002rrk.3	-	16	2577	c.2536G>A	c.(2536-2538)GAA>AAA	p.E846K	SOS1_uc002rrj.3_Missense_Mutation_p.E460K	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	846	Ras-GEF.		E -> K (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				ACTCTTTCTTCTAAATTTTCA	0.308									Noonan_syndrome				0	0	0	0.010818	0	30	76										T	39234309	C	T	39234309	3	4	7	1	0	0	0	0	1	0	0	0	14936	922	32	1	1497	1	SOS1	2	39234309	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1949836	39234309	203965064	56	1525										
HAAO	23498	broad.mit.edu	37	chr2	42996988	42996988	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agagggaatggtggctccttGagcagctggtctgcacccac	14	11	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:42996988G>C	uc002rst.3	-	7	570	c.495C>G	c.(493-495)CTC>CTG	p.L165L		NM_012205	NP_036337	P46952	3HAO_HUMAN	3-hydroxyanthranilate 3,4-dioxygenase	165	Linker (By similarity).				neuron homeostasis|pyridine nucleotide biosynthetic process|quinolinate biosynthetic process|response to cadmium ion|response to zinc ion|tryptophan catabolic process	cytosol|soluble fraction	3-hydroxyanthranilate 3,4-dioxygenase activity|electron carrier activity|ferrous iron binding			ovary(1)	1						GTGGCTCCTTGAGCAGCTGGT	0.637													0	0	0	0.00499	0	16	75										C	42996988	G	C	42996988	2	2	7	1	0	0	0	0	0	0	0	1	6937	1277	45	1		1	HAAO	2	42996988	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3762679	42996988	200202385	57	1526										
MSH2	4436	broad.mit.edu	37	chr2	47693913	47693913	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ataaaaactttagtactgtaGatatccagaagaatggtgtt	8	4	0	3	rs63750675		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:47693913G>A	uc002rvy.1	+	10	1695	c.1627G>A	c.(1627-1629)GAT>AAT	p.D543N	MSH2_uc010yoh.1_Missense_Mutation_p.D477N|MSH2_uc002rvz.2_Missense_Mutation_p.D543N|MSH2_uc010fbg.2_Missense_Mutation_p.D353N|MSH2_uc010fbh.1_RNA|MSH2_uc010fbi.1_Intron	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	543					B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(2)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TAGTACTGTAGATATCCAGAA	0.323			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.002299	0	20	72										A	47693913	G	A	47693913	3	1	7	1	0	0	0	0	1	0	0	0	9870	942	33	1	1665	1	MSH2	2	47693913	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4696925	47693913	195505460	58	1527										
FOXN2	3344	broad.mit.edu	37	chr2	48573510	48573510	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tagtggacagtgagtcagcaGatgatgaactcacaaacttg	11	7	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:48573510G>C	uc002rwh.1	+	3	472	c.157G>C	c.(157-159)GAT>CAT	p.D53H		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	53					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TGAGTCAGCAGATGATGAACT	0.448													0	0	0	0.001855	0	11	62										C	48573510	G	C	48573510	3	2	7	1	0	0	0	0	1	0	0	0	6020	942	33	1	159	1	FOXN2	2	48573510	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	879597	48573510	194625863	59	1528										
ERLEC1	27248	broad.mit.edu	37	chr2	54035547	54035547	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccacatatccaaattgacaGatgaccaactcataaaagag	5	11	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:54035547G>A	uc002rxl.2	+	9	1271	c.991G>A	c.(991-993)GAT>AAT	p.D331N	ASB3_uc002rxi.3_Intron|ERLEC1_uc002rxm.2_Missense_Mutation_p.D331N|ERLEC1_uc002rxn.2_Intron	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	331				D -> G (in Ref. 3; BAA91974).	ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						CAAATTGACAGATGACCAACT	0.398													0	0	0	0.00245	0	14	57										A	54035547	G	A	54035547	3	1	7	1	0	0	0	0	1	0	0	0	5231	942	33	1	1025	1	ERLEC1	2	54035547	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5462037	54035547	189163826	60	1529										
FBXO48	554251	broad.mit.edu	37	chr2	68691345	68691345	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgattttttttccccttatCtttccagttctgcttctaga	5	10	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:68691345C>G	uc002seo.2	-	4	872	c.464G>C	c.(463-465)AGA>ACA	p.R155T		NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	155											0						TTCCCCTTATCTTTCCAGTTC	0.358													0	0	0	0.006999	0	37	185										G	68691345	C	G	68691345	3	3	7	1	0	0	0	0	1	0	0	0	5757	913	32	1	7	1	FBXO48	2	68691345	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	14655798	68691345	174508028	61	1530										
EXOC6B	23233	broad.mit.edu	37	chr2	72968519	72968519	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgaaagttgcacattttctCaatttctcggtcgtgattac	7	8	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:72968519C>T	uc010fep.2	-	2	331	c.193G>A	c.(193-195)GAG>AAG	p.E65K	EXOC6B_uc002sij.2_Missense_Mutation_p.E65K	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	65	Potential.				protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						CACATTTTCTCAATTTCTCGG	0.408													0	0	0	0.003163	0	12	114										T	72968519	C	T	72968519	3	4	7	1	0	0	0	0	1	0	0	0	5309	835	29	1	2326	1	EXOC6B	2	72968519	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4277174	72968519	170230854	62	1531										
EIF2AK3	9451	broad.mit.edu	37	chr2	88874949	88874949	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tccattgggctaggagagctGagtggccagtctgtgctaaa	14	8	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:88874949G>A	uc002stc.3	-	13	2254	c.2052C>T	c.(2050-2052)CTC>CTT	p.L684L		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	684	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						TAGGAGAGCTGAGTGGCCAGT	0.408													0	0	0	0.001168	0	6	54										A	88874949	G	A	88874949	2	1	7	1	0	0	0	0	0	0	0	1	4998	1277	45	1		1	EIF2AK3	2	88874949	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	15906430	88874949	154324424	63	1532										
KIAA1310	55683	broad.mit.edu	37	chr2	97276603	97276603	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	actggagtcttcatatccaaGaggggatcatctacatccta	8	10	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:97276603G>C	uc002swn.3	-	11	1325	c.1179C>G	c.(1177-1179)CTC>CTG	p.L393L	KIAA1310_uc002swh.3_Silent_p.L281L|KIAA1310_uc002swi.3_Silent_p.L294L|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Silent_p.L306L|KIAA1310_uc010fhz.2_Silent_p.L187L|KIAA1310_uc002swl.3_Silent_p.L294L|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Silent_p.L187L|KIAA1310_uc002swp.1_Silent_p.L294L|KIAA1310_uc002swq.1_Silent_p.L165L|KIAA1310_uc010fhy.1_Silent_p.L294L	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	393											0						TCATATCCAAGAGGGGATCAT	0.458													0	0	0	0.008871	0	19	92										C	97276603	G	C	97276603	2	2	7	1	0	0	0	0	0	0	0	1	8222	929	33	1		1	KIAA1310	2	97276603	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8401654	97276603	145922770	64	1533										
CNNM3	26505	broad.mit.edu	37	chr2	97483169	97483169	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcagcaccatcactcgtttCtacaaccatccgctccactt	3	18	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:97483169C>G	uc002swy.2	+	1	1179	c.1155C>G	c.(1153-1155)TTC>TTG	p.F385L	CNNM3_uc002swz.2_Missense_Mutation_p.F385L	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	385					ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						TCACTCGTTTCTACAACCATC	0.592													0	0	0	0.008291	0	11	71										G	97483169	C	G	97483169	3	3	7	1	0	0	0	0	1	0	0	0	3614	912	32	1	1157	1	CNNM3	2	97483169	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	206566	97483169	145716204	65	1534										
AFF3	3899	broad.mit.edu	37	chr2	100199373	100199373	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctggaagaagttaagtcctCgctggtgtatttgtgtttag	13	5	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:100199373C>T	uc002tag.2	-	16	2916	c.2680G>A	c.(2680-2682)GAG>AAG	p.E894K	AFF3_uc002taf.2_Missense_Mutation_p.E919K|AFF3_uc010fiq.1_Missense_Mutation_p.E894K|AFF3_uc010yvr.1_Missense_Mutation_p.E1047K|AFF3_uc002tah.1_Missense_Mutation_p.E919K	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	894					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GTTAAGTCCTCGCTGGTGTAT	0.463													0	0	0	0.003163	0	13	52										T	100199373	C	T	100199373	3	4	7	1	0	0	0	0	1	0	0	0	358	893	31	1	1036	1	AFF3	2	100199373	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2716204	100199373	143000000	66	1535										
MERTK	10461	broad.mit.edu	37	chr2	112740456	112740456	+	Silent	SNP	G	G	A													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttaaatgtcactgtgtttctGaatgaatctagtgataatgt							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:112740456G>A	uc002thk.1	+	8	1304	c.1182G>A	c.(1180-1182)CTG>CTA	p.L394L	MERTK_uc002thl.1_Silent_p.L218L	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	394	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						CTGTGTTTCTGAATGAATCTA	0.448													0	0	0	0.004289	0	36	123										A	112740456	G	A	112740456	2	1	7	1	0	0	0	0	0	0	0	1	9479	1277	45	1		1	MERTK	2	112740456	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	12541083	112740456	130458917	67	1536	11	2	1	5		4	3	82	N	G	1.101245e-06
MERTK	10461	broad.mit.edu	37	chr2	112740460	112740460	+	Missense_Mutation	SNP	G	G	A													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgtcactgtgtttctgaatGaatctagtgataatgtggac							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:112740460G>A	uc002thk.1	+	8	1308	c.1186G>A	c.(1186-1188)GAA>AAA	p.E396K	MERTK_uc002thl.1_Missense_Mutation_p.E220K	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	396	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GTTTCTGAATGAATCTAGTGA	0.453													0	0	0	0.003271	0	34	116										A	112740460	G	A	112740460	3	1	7	1	0	0	0	0	1	0	0	0	9479	1291	45	1	1216	1	MERTK	2	112740460	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4	112740460	130458913	68	1537	11	2	1	5		4	3	82	N	G	1.101245e-06
MERTK	10461	broad.mit.edu	37	chr2	112740501	112740501	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcagatggatgaagcctccGactaagcagcaggatggaga	13	8	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:112740501G>A	uc002thk.1	+	8	1349	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P	MERTK_uc002thl.1_Silent_p.P233P	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	409	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TGAAGCCTCCGACTAAGCAGC	0.463													0	0	0	0.00632	0	20	84										A	112740501	G	A	112740501	2	1	7	1	0	0	0	0	0	0	0	1	9479	1045	37	1		1	MERTK	2	112740501	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	41	112740501	130458872	69	1538			1	5		4	3	82	N	G	1.101245e-06
MERTK	10461	broad.mit.edu	37	chr2	112740537	112740537	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggagaactggtgggctaccgGatatcccacgtgtggcagag	16	9	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:112740537G>C	uc002thk.1	+	8	1385	c.1263G>C	c.(1261-1263)CGG>CGC	p.R421R	MERTK_uc002thl.1_Silent_p.R245R	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	421	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TGGGCTACCGGATATCCCACG	0.453													0	0	0	0.00333	0	13	68										C	112740537	G	C	112740537	2	2	7	1	0	0	0	0	0	0	0	1	9479	1161	41	1		1	MERTK	2	112740537	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	36	112740537	130458836	70	1539			1	5		4	3	82	N	G	1.101245e-06
IWS1	55677	broad.mit.edu	37	chr2	128260414	128260414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaattcttcttcctcttcatCaccagattctccaaatatgt	2	12	6	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:128260414C>T	uc002ton.2	-	5	1747	c.1444G>A	c.(1444-1446)GAT>AAT	p.D482N	IWS1_uc010yzl.1_RNA|uc002too.1_5'Flank	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	482	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TCCTCTTCATCACCAGATTCT	0.308													0	0	0	0.00245	0	13	36										T	128260414	C	T	128260414	3	4	7	1	0	0	0	0	1	0	0	0	7931	826	29	1	1055	1	IWS1	2	128260414	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	15519877	128260414	114938959	71	1540										
UGGT1	56886	broad.mit.edu	37	chr2	128918082	128918082	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctttgagtcttccaaaatgGatttcattttgtctcatgcc	6	9	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:128918082G>A	uc002tps.2	+	24	2789	c.2611G>A	c.(2611-2613)GAT>AAT	p.D871N	UGGT1_uc010fme.1_Missense_Mutation_p.D746N|UGGT1_uc002tpr.2_Missense_Mutation_p.D847N	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	871					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TTCCAAAATGGATTTCATTTT	0.403													0	0	0	0.001984	0	5	40										A	128918082	G	A	128918082	3	1	7	1	0	0	0	0	1	0	0	0	16938	1174	41	1	2705	1	UGGT1	2	128918082	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	657668	128918082	114281291	72	1541										
RAB6C	84084	broad.mit.edu	37	chr2	130738132	130738132	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagaggaaagccaaagggctGaatgttacgtttattgaaac	12	5	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:130738132G>A	uc002tpx.1	+	1	898	c.444G>A	c.(442-444)CTG>CTA	p.L148L	uc002tpw.1_5'Flank	NM_032144	NP_115520	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	148					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			lung(1)	1	Colorectal(110;0.1)					CCAAAGGGCTGAATGTTACGT	0.463													0	0	0	0.004878	0	35	158										A	130738132	G	A	130738132	2	1	7	1	0	0	0	0	0	0	0	1	12953	1277	45	1		1	RAB6C	2	130738132	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1820050	130738132	112461241	73	1542										
NCKAP5	344148	broad.mit.edu	37	chr2	133543084	133543084	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tccaggagaatatattccttCattcgagttcatgcaatctt	6	9	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:133543084C>T	uc002ttp.2	-	14	1674	c.1300G>A	c.(1300-1302)GAA>AAA	p.E434K	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	434							protein binding				0						TATATTCCTTCATTCGAGTTC	0.458													0	0	0	0.001855	0	12	55										T	133543084	C	T	133543084	3	4	7	1	0	0	0	0	1	0	0	0	10223	835	29	1	4457	1	NCKAP5	2	133543084	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2804952	133543084	109656289	74	1543										
ZEB2	9839	broad.mit.edu	37	chr2	145161507	145161507	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctgtccctggcttgtgtgtCaccatatgccgctcgagctg	11	13	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:145161507C>T	uc002tvu.2	-	6	1263	c.783G>A	c.(781-783)GTG>GTA	p.V261V	ZEB2_uc002tvv.2_Silent_p.V255V|ZEB2_uc010zbm.1_Silent_p.V232V|ZEB2_uc010fnp.2_Silent_p.V169V|ZEB2_uc010fnq.1_Silent_p.V290V	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	261	C2H2-type 2.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCTTGTGTGTCACCATATGCC	0.418													0	0	0	0.010729	0	10	97										T	145161507	C	T	145161507	2	4	7	1	0	0	0	0	0	0	0	1	17621	813	29	1		1	ZEB2	2	145161507	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	11618423	145161507	98037866	75	1544										
NEB	4703	broad.mit.edu	37	chr2	152496556	152496556	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatgcctctcatccactggaGatcagacttgtacatattct	6	11	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:152496556G>C	uc010fnx.2	-	62	8895	c.8704C>G	c.(8704-8706)CTC>GTC	p.L2902V	NEB_uc002txu.2_Missense_Mutation_p.L6V	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2902	Nebulin 78.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATCCACTGGAGATCAGACTTG	0.378													0	0	0	0.007291	0	25	89										C	152496556	G	C	152496556	3	2	7	1	0	0	0	0	1	0	0	0	10302	942	33	1	17466	1	NEB	2	152496556	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7335049	152496556	90702817	76	1545										
SCN3A	6328	broad.mit.edu	37	chr2	165947272	165947272	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcatcgggatcaaacttttcCcaaacctcatagaacatctc	5	13	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:165947272C>T	uc002ucx.2	-	28	5883	c.5391G>A	c.(5389-5391)TGG>TGA	p.W1797*	SCN3A_uc010zcy.1_Nonsense_Mutation_p.W280*|SCN3A_uc002ucy.2_Nonsense_Mutation_p.W1748*|SCN3A_uc002ucz.2_Nonsense_Mutation_p.W1748*	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1797						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CAAACTTTTCCCAAACCTCAT	0.463													0	0	0	0.00308	0	8	72										T	165947272	C	T	165947272	4	4	7	1	0	0	0	0	0	1	0	0	13918	624	22	2	615	2	SCN3A	2	165947272	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	13450716	165947272	77252101	77	1546										
TTC21B	79809	broad.mit.edu	37	chr2	166747011	166747011	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caggtctccatccaggttttCaaatacttcacctccaacag	5	14	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:166747011C>G	uc002udk.2	-	24	3374	c.3241G>C	c.(3241-3243)GAA>CAA	p.E1081Q	TTC21B_uc002udj.1_RNA	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	1081						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						TCCAGGTTTTCAAATACTTCA	0.358													0	0	0	0.004007	0	16	23										G	166747011	C	G	166747011	3	3	7	1	0	0	0	0	1	0	0	0	16685	835	29	1	733	1	TTC21B	2	166747011	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	799739	166747011	76452362	78	1547										
KBTBD10	10324	broad.mit.edu	37	chr2	170359659	170359659	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcaagatgatgtagaaataGactctgatggtcacacggat	10	6	3	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:170359659G>C	uc010zdh.1	+	10	929	c.871G>C	c.(871-873)GAC>CAC	p.D291H	BBS5_uc002uet.2_Missense_Mutation_p.D291H|BBS5_uc010fpw.2_Missense_Mutation_p.D270H	NM_152384	NP_689597	O60662	KBTBA_HUMAN	Bardet-Biedl syndrome 5	356	Kelch 1.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						TGTAGAAATAGACTCTGATGG	0.373													0	0	0	0.004482	0	9	17										C	170359659	G	C	170359659	3	2	7	1	0	0	0	0	1	0	0	0	7990	942	33	1		1	KBTBD10	2	170359659	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3612648	170359659	72839714	79	1548										
C2orf77	129881	broad.mit.edu	37	chr2	170506887	170506887	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttaattctgctttgtttttTtcatctttttctctttctct	2	8	5	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:170506887T>C	uc002ufe.2	-	7	1198	c.1104A>G	c.(1102-1104)GAA>GAG	p.E368E		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	368	Potential.										0						CTTTGTTTTTTTCATCTTTTT	0.308													0	0	0	0.004672	0	2	16										C	170506887	T	C	170506887	2	2	7	1	0	0	0	0	0	0	0	1	2194	1838	64	5		5	C2orf77	2	170506887	Silent	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	147228	170506887	72692486	80	1549										
TTN	7273	broad.mit.edu	37	chr2	179402447	179402447	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accttcatcttcctgttcctCtgtcattactgtaagagtgt	6	11	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:179402447C>T	uc010zfg.1	-	304	92007	c.91783G>A	c.(91783-91785)GAG>AAG	p.E30595K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E24290K|TTN_uc010zfi.1_Missense_Mutation_p.E24223K|TTN_uc010zfj.1_Missense_Mutation_p.E24098K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31522							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTGTTCCTCTGTCATTACT	0.428													0	0	0	0.006214	0	9	31										T	179402447	C	T	179402447	3	4	7	1	0	0	0	0	1	0	0	0	16732	922	32	1	8524	1	TTN	2	179402447	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	8895560	179402447	63796926	81	1550										
TTN	7273	broad.mit.edu	37	chr2	179481355	179481355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttctttgggtgcacttgggcGagctgaaaaaaaatgcactc	11	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:179481355G>A	uc010zfg.1	-	206	40683	c.40459C>T	c.(40459-40461)CGC>TGC	p.R13487C	TTN_uc010zfh.1_Missense_Mutation_p.R7182C|TTN_uc010zfi.1_Missense_Mutation_p.R7115C|TTN_uc010zfj.1_Missense_Mutation_p.R6990C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14414							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACTTGGGCGAGCTGAAAAA	0.383													0	0	0	0.006214	0	10	32										A	179481355	G	A	179481355	3	1	7	1	0	0	0	0	1	0	0	0	16732	1058	37	1	59954	1	TTN	2	179481355	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	78908	179481355	63718018	82	1551										
TTN	7273	broad.mit.edu	37	chr2	179528787	179528787	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttaggaggcaccaccgacaCtttcttttcagggataatct	8	10	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:179528787C>A	uc010zfk.1	-	14	1305	c.757G>T	c.(757-759)GTG>TTG	p.V253L	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11465							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACCGACACTTTCTTTTCA	0.383													1	0	1.08611e-07	0.010729	1.1424e-07	9	48										A	179528787	C	A	179528787	3	1	7	1	0	0	0	0	1	0	0	0	16732	580	20	4		4	TTN	2	179528787	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	47432	179528787	63670586	83	1552										
PDE1A	5136	broad.mit.edu	37	chr2	183094834	183094834	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtacttgctgtaaccaacttCtaaagcttctgcaaaggtga	8	9	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:183094834C>T	uc002uos.2	-	7	706	c.622G>A	c.(622-624)GAA>AAA	p.E208K	PDE1A_uc010zfp.1_Missense_Mutation_p.E104K|PDE1A_uc002uoq.1_Missense_Mutation_p.E208K|PDE1A_uc010zfq.1_Missense_Mutation_p.E208K|PDE1A_uc002uor.2_Missense_Mutation_p.E192K|PDE1A_uc002uou.2_Missense_Mutation_p.E174K	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	208	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			TAACCAACTTCTAAAGCTTCT	0.333													0	0	0	0.001168	0	6	35										T	183094834	C	T	183094834	3	4	7	1	0	0	0	0	1	0	0	0	11633	922	32	1	1099	1	PDE1A	2	183094834	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3566047	183094834	60104539	84	1553										
ITGAV	3685	broad.mit.edu	37	chr2	187455093	187455093	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttccgccgcggcgacggctgCgcctcggtccccgcggcctc	14	20	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:187455093C>T	uc002upq.2	+	1	304	c.28C>T	c.(28-30)CGC>TGC	p.R10C	ITGAV_uc010frs.2_Missense_Mutation_p.R10C	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	10					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GCGACGGCTGCGCCTCGGTCC	0.706													0	0	0	0.000602	0	5	21										T	187455093	C	T	187455093	3	4	7	1	0	0	0	0	1	0	0	0	7888	768	27	2	30	2	ITGAV	2	187455093	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4360259	187455093	55744280	85	1554										
ITGAV	3685	broad.mit.edu	37	chr2	187516805	187516805	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcactgcctggaacagctctCaaagtttcctggtaagggta	10	10	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:187516805C>G	uc002upq.2	+	15	1770	c.1494C>G	c.(1492-1494)CTC>CTG	p.L498L	ITGAV_uc010frs.2_Silent_p.L462L|ITGAV_uc010zfv.1_Silent_p.L452L	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	498	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GAACAGCTCTCAAAGTTTCCT	0.378													0	0	0	0.004482	0	8	16										G	187516805	C	G	187516805	2	3	7	1	0	0	0	0	0	0	0	1	7888	813	29	1		1	ITGAV	2	187516805	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	61712	187516805	55682568	86	1555										
RFTN2	130132	broad.mit.edu	37	chr2	198498569	198498569	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccacttaacgtcccttcattCcaacttctacagttttcatc	2	15	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:198498569C>T	uc002uuo.3	-	4	993	c.591G>A	c.(589-591)TGG>TGA	p.W197*		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	197						plasma membrane					0						TCCCTTCATTCCAACTTCTAC	0.408													0	0	0	0.00499	0	16	139										T	198498569	C	T	198498569	4	4	7	1	0	0	0	0	0	1	0	0	13259	856	30	1	938	1	RFTN2	2	198498569	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10981764	198498569	44700804	87	1556										
AOX1	316	broad.mit.edu	37	chr2	201468754	201468754	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttttagacaagtccaaaactCttcgcagaagaggagtttct	8	8	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:201468754C>T	uc002uvx.2	+	8	704	c.603C>T	c.(601-603)CTC>CTT	p.L201L		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	201					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GTCCAAAACTCTTCGCAGAAG	0.303													0	0	0	0.000602	0	4	50										T	201468754	C	T	201468754	2	4	7	1	0	0	0	0	0	0	0	1	729	900	32	1		1	AOX1	2	201468754	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2970185	201468754	41730619	88	1557										
CLK1	1195	broad.mit.edu	37	chr2	201721702	201721702	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtgagtcaacttattactgTgcaaaactgagaataaagag	9	5	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:201721702T>A	uc002uwe.2	-	8	1020	c.839A>T	c.(838-840)CAC>CTC	p.H280L	CLK1_uc002uwd.2_Missense_Mutation_p.H103L|CLK1_uc010zhi.1_Missense_Mutation_p.H322L|CLK1_uc002uwf.2_Missense_Mutation_p.H54L|CLK1_uc002uwg.2_Missense_Mutation_p.H129L|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	280	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						CTTATTACTGTGCAAAACTGA	0.328													0	0	0	0.004672	0	3	40										A	201721702	T	A	201721702	3	1	7	1	0	0	0	0	1	0	0	0	3536	1696	59	5	639	5	CLK1	2	201721702	Missense_Mutation	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	252948	201721702	41477671	89	1558										
BMPR2	659	broad.mit.edu	37	chr2	203420557	203420557	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcaactggacagcaggacttCacacagactgcaaatggcca	10	12	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:203420557C>T	uc002uzf.3	+	12	3317	c.2169C>T	c.(2167-2169)TTC>TTT	p.F723F	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	723	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AGCAGGACTTCACACAGACTG	0.473													0	0	0	0.004482	0	9	68										T	203420557	C	T	203420557	2	4	7	1	0	0	0	0	0	0	0	1	1471	825	29	1		1	BMPR2	2	203420557	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1698855	203420557	39778816	90	1559										
PIKFYVE	200576	broad.mit.edu	37	chr2	209218754	209218754	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accctctatatattcgttctCattccaaagctgtgctgaga	6	11	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:209218754C>T	uc002vcz.2	+	40	6135	c.5977C>T	c.(5977-5979)CAT>TAT	p.H1993Y		NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1993	Catalytic.|PIPK.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TATTCGTTCTCATTCCAAAGC	0.418													0	0	0	0.005443	0	24	107										T	209218754	C	T	209218754	3	4	7	1	0	0	0	0	1	0	0	0	11924	826	29	1	6142	1	PIKFYVE	2	209218754	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5798197	209218754	33980619	91	1560										
ANKZF1	55139	broad.mit.edu	37	chr2	220094995	220094995	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagccatgtcgccggctccaGatgcagccccggctcctgcg	12	18	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:220094995G>A	uc002vkg.2	+	2	190	c.16G>A	c.(16-18)GAT>AAT	p.D6N	ATG9A_uc002vke.1_5'Flank|ATG9A_uc002vkf.1_5'Flank|ANKZF1_uc010zkv.1_Missense_Mutation_p.D6N|ANKZF1_uc010zkw.1_Intron|ANKZF1_uc002vkh.2_Intron|ANKZF1_uc002vki.2_Missense_Mutation_p.D6N|ANKZF1_uc002vkj.1_5'Flank	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	6						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCGGCTCCAGATGCAGCCCC	0.602													0	0	0	0.000602	0	5	24										A	220094995	G	A	220094995	3	1	7	1	0	0	0	0	1	0	0	0	693	942	33	1	18	1	ANKZF1	2	220094995	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	10876241	220094995	23104378	92	1561										
COL4A4	1286	broad.mit.edu	37	chr2	227924258	227924258	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctgaccattcactcctggtGagccgggagggcctgggggc	16	12	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:227924258G>A	uc010zlt.1	-	28	2900	c.2246C>T	c.(2245-2247)TCA>TTA	p.S749L		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	749	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CACTCCTGGTGAGCCGGGAGG	0.552													0	0	0	0.001368	0	13	61										A	227924258	G	A	227924258	3	1	7	1	0	0	0	0	1	0	0	0	3693	1294	45	1	2910	1	COL4A4	2	227924258	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7829263	227924258	15275115	93	1562										
SP100	6672	broad.mit.edu	37	chr2	231407626	231407626	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcagaaacatttttgcaattCaggaaacaagcaagaacatt	6	7	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:231407626C>G	uc002vqu.1	+	29	2764	c.2623C>G	c.(2623-2625)CAG>GAG	p.Q875E	SP100_uc010fxp.1_Missense_Mutation_p.Q193E	NM_001080391	NP_001073860	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 1	Error:Variant_position_missing_in_P23497_after_alignment					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TTTTGCAATTCAGGAAACAAG	0.373													0	0	0	0.00308	0	8	56										G	231407626	C	G	231407626	3	3	7	1	0	0	0	0	1	0	0	0	14960	827	29	1	3287	1	SP100	2	231407626	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3483368	231407626	11791747	94	1563										
UGT1A5	54579	broad.mit.edu	37	chr2	234622344	234622344	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tccttatgcaagccttgcctCtgagctttttcagagagagg	10	10	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:234622344C>G	uc002vuw.2	+	1	707	c.707C>G	c.(706-708)TCT>TGT	p.S236C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Missense_Mutation_p.S236C	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	236					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		AGCCTTGCCTCTGAGCTTTTT	0.527													0	0	0	0.006999	0	39	161										G	234622344	C	G	234622344	3	3	7	1	0	0	0	0	1	0	0	0	16945	913	32	1	709	1	UGT1A5	2	234622344	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3214718	234622344	8577029	95	1564										
HJURP	55355	broad.mit.edu	37	chr2	234749538	234749538	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaaaccctggaagtgagggtCtggatttaattttcctaaga	11	6	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:234749538C>T	uc002vvg.2	-	8	1954	c.1888G>A	c.(1888-1890)GAC>AAC	p.D630N	HJURP_uc010znd.1_Missense_Mutation_p.D569N|HJURP_uc010zne.1_Missense_Mutation_p.D538N	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	630					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		AAGTGAGGGTCTGGATTTAAT	0.448													0	0	0	0.004007	0	16	61										T	234749538	C	T	234749538	3	4	7	1	0	0	0	0	1	0	0	0	7189	913	32	1	366	1	HJURP	2	234749538	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	127194	234749538	8449835	96	1565										
PER2	8864	broad.mit.edu	37	chr2	239184478	239184478	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctgcagggaggtggaccttCagctcctttagtgtttttat	11	8	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:239184478C>T	uc002vyc.2	-	4	591	c.354G>A	c.(352-354)CTG>CTA	p.L118L	PER2_uc010znv.1_Silent_p.L118L|PER2_uc010znw.1_Silent_p.L118L|PER2_uc010fyx.1_Silent_p.L118L	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	118					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GGTGGACCTTCAGCTCCTTTA	0.517													0	0	0	0.001368	0	12	65										T	239184478	C	T	239184478	2	4	7	1	0	0	0	0	0	0	0	1	11730	813	29	1		1	PER2	2	239184478	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4434940	239184478	4014895	97	1566										
ANKMY1	51281	broad.mit.edu	37	chr2	241468765	241468765	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcctggcagggctgtgggtGatgaagctggagaactcagg	17	7	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:241468765G>T	uc002vyz.1	-	4	604	c.375C>A	c.(373-375)ATC>ATA	p.I125I	ANKMY1_uc002vza.1_Intron|ANKMY1_uc010fzd.1_Silent_p.I214I|ANKMY1_uc002vzb.1_Intron|ANKMY1_uc002vzc.1_Intron|ANKMY1_uc002vzd.1_Intron|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Intron	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	125							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GGCTGTGGGTGATGAAGCTGG	0.562													1	0	5.9392e-07	0.001168	6.23752e-07	4	28										T	241468765	G	T	241468765	2	4	7	1	0	0	0	0	0	0	0	1	634	1280	45	3		3	ANKMY1	2	241468765	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2284287	241468765	1730608	98	1567										
MTERFD2	130916	broad.mit.edu	37	chr2	242035439	242035439	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcctcgtcgtcgtcctcatCctcatcattgtcctccgcct	5	19	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr2:242035439C>T	uc002wan.1	-	3	1700	c.1207G>A	c.(1207-1209)GAT>AAT	p.D403N	MTERFD2_uc010zoj.1_Missense_Mutation_p.D186N	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	374										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		tcgtcctcatcctcatcattg	0.189													0	0	0	0.003163	0	16	68										T	242035439	C	T	242035439	3	4	7	1	0	0	0	0	1	0	0	0	9920	855	30	1	29	1	MTERFD2	2	242035439	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	566674	242035439	1163934	99	1568										
TRNT1	51095	broad.mit.edu	37	chr3	3189210	3189210	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggtttttcaccaaagccagtGactcttttggcctcattatt	7	10	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:3189210G>A	uc003bpp.3	+	7	981	c.879G>A	c.(877-879)GTG>GTA	p.V293V	TRNT1_uc010hbv.2_Silent_p.V273V|TRNT1_uc003bpm.2_RNA	NM_182916	NP_886552	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	293					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding				0				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		CAAAGCCAGTGACTCTTTTGG	0.353													0	0	0	0.003954	0	22	47										A	3189210	G	A	3189210	2	1	7	1	0	0	0	0	0	0	0	1	16570	1277	45	1		1	TRNT1	3	3189210	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		3189210	194833220	100	1569										
ZFYVE20	64145	broad.mit.edu	37	chr3	15124116	15124116	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctggcactggtgagcttgtCtgtaaccacaacaccaacag	10	12	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:15124116C>G	uc003bzm.1	-	9	1213	c.599_splice	c.e9-1	p.N200_splice	ZFYVE20_uc010hek.1_Splice_Site_p.N200_splice|ZFYVE20_uc011avn.1_Intron	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein						blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						GTGAGCTTGTCTGTAACCACA	0.572													0	0	0	0.006214	0	10	18										G	15124116	C	G	15124116	5	3	7	1	0	0	0	0	0	0	1	0	17663	927	32	1	1780	1	ZFYVE20	3	15124116	Splice_Site	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	11934906	15124116	182898314	101	1570										
EAF1	85403	broad.mit.edu	37	chr3	15475961	15475961	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cacctatgccattcagagctCcaacgaagcctccagttgga	8	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:15475961C>T	uc003bzu.2	+	4	665	c.442C>T	c.(442-444)CCA>TCA	p.P148S	EAF1_uc011avq.1_Missense_Mutation_p.P47S	NM_033083	NP_149074	Q96JC9	EAF1_HUMAN	ELL associated factor 1	148	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cajal body|nuclear speck	protein binding			central_nervous_system(1)	1						ATTCAGAGCTCCAACGAAGCC	0.522													0	0	0	0.004878	0	38	244										T	15475961	C	T	15475961	3	4	7	1	0	0	0	0	1	0	0	0	4875	855	30	1	456	1	EAF1	3	15475961	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	351845	15475961	182546469	102	1571										
VIPR1	7433	broad.mit.edu	37	chr3	42573763	42573763	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcctgtttatttgcatcatCcgaatcctgcttcagaaact	5	11	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:42573763C>T	uc003clf.2	+	10	1072	c.948C>T	c.(946-948)ATC>ATT	p.I316I	VIPR1_uc011azl.1_Silent_p.I268I|VIPR1_uc011azm.1_Silent_p.I106I|VIPR1_uc011azn.1_Silent_p.I289I|VIPR1_uc003clg.2_5'UTR	NM_004624	NP_004615	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	316	Helical; Name=5; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.241)		TTTGCATCATCCGAATCCTGC	0.567													0	0	0	0.006122	0	18	29										T	42573763	C	T	42573763	2	4	7	1	0	0	0	0	0	0	0	1	17166	845	30	1		1	VIPR1	3	42573763	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	27097802	42573763	155448667	103	1572										
CCRL2	9034	broad.mit.edu	37	chr3	46450087	46450087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aattcgtggtttataaacctCagatggaagaccagaaatac	8	7	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:46450087C>G	uc003cpp.3	+	2	802	c.517C>G	c.(517-519)CAG>GAG	p.Q173E	CCRL2_uc010hjg.2_Missense_Mutation_p.Q185E|CCRL2_uc010hjf.2_Missense_Mutation_p.Q173E	NM_003965	NP_003956	O00421	CCRL2_HUMAN	chemokine (C-C motif) receptor-like 2 isoform 1	173	Extracellular (Potential).				chemotaxis|inflammatory response	integral to plasma membrane	CCR chemokine receptor binding|chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)		TTATAAACCTCAGATGGAAGA	0.463													0	0	0	0.001368	0	13	68										G	46450087	C	G	46450087	3	3	7	1	0	0	0	0	1	0	0	0	2950	827	29	1	559	1	CCRL2	3	46450087	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3876324	46450087	151572343	104	1573										
APEH	327	broad.mit.edu	37	chr3	49713611	49713611	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tggacgtcagtgccagcgatGatgagatagccaggctgaag	15	8	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:49713611G>A	uc003cxf.2	+	6	965	c.565G>A	c.(565-567)GAT>AAT	p.D189N	APEH_uc010hkw.1_Missense_Mutation_p.D189N	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	189					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGCCAGCGATGATGAGATAGC	0.592													0	0	0	0.001168	0	6	46										A	49713611	G	A	49713611	3	1	7	1	0	0	0	0	1	0	0	0	768	1290	45	1	587	1	APEH	3	49713611	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3263524	49713611	148308819	105	1574										
MST1R	4486	broad.mit.edu	37	chr3	49933757	49933757	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcccctcgggcactcagattCcctgccacccatccctgggg	9	19	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:49933757C>T	uc003cxy.3	-	10	2784	c.2520G>A	c.(2518-2520)GGG>GGA	p.G840G	MST1R_uc011bdd.1_Silent_p.G841G|MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	840	IPT/TIG 3.|Extracellular (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CACTCAGATTCCCTGCCACCC	0.597													0	0	0	0.003954	0	22	75										T	49933757	C	T	49933757	2	4	7	1	0	0	0	0	0	0	0	1	9891	842	30	1		1	MST1R	3	49933757	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	220146	49933757	148088673	106	1575										
TLR9	54106	broad.mit.edu	37	chr3	52264889	52264889	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agggagcaggcacccaccatCtggatgtagttgaccatttt	11	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:52264889C>T	uc003ddb.2	-	2	228	c.18G>A	c.(16-18)CAG>CAA	p.Q6Q	TLR9_uc003ddc.1_5'Flank|TWF2_uc003ddd.2_Silent_p.Q202Q|TWF2_uc010hmc.2_Silent_p.Q202Q	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	Error:Variant_position_missing_in_Q9NR96_after_alignment					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CACCCACCATCTGGATGTAGT	0.617													0	0	0	0.004672	0	3	15										T	52264889	C	T	52264889	2	4	7	1	0	0	0	0	0	0	0	1	15955	912	32	1		1	TLR9	3	52264889	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2331132	52264889	145757541	107	1576										
GLYCTK	132158	broad.mit.edu	37	chr3	52325046	52325046	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggacaacctcccggaccgcGatgcgctgcgggctgcactg	14	15	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:52325046G>A	uc003ddo.2	+	3	544	c.448G>A	c.(448-450)GAT>AAT	p.D150N	GLYCTK_uc003ddq.2_Missense_Mutation_p.D150N|GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddn.2_RNA|GLYCTK_uc003ddp.1_Missense_Mutation_p.D150N|GLYCTK_uc003ddr.2_5'Flank	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	150					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		CCCGGACCGCGATGCGCTGCG	0.617													0	0	0	0.001168	0	6	42										A	52325046	G	A	52325046	3	1	7	1	0	0	0	0	1	0	0	0	6482	1058	37	1	454	1	GLYCTK	3	52325046	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	60157	52325046	145697384	108	1577										
NISCH	11188	broad.mit.edu	37	chr3	52523592	52523592	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atccaggccacctcggaggaGaatcagatcccctcgcactt	9	15	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:52523592G>C	uc011beg.1	+	18	3426	c.3354G>C	c.(3352-3354)GAG>GAC	p.E1118D	NISCH_uc003ded.3_Missense_Mutation_p.E1118D|NISCH_uc003dee.3_Missense_Mutation_p.E607D|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_5'Flank	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1118					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCTCGGAGGAGAATCAGATCC	0.458													0	0	0	0.010729	0	12	77										C	52523592	G	C	52523592	3	2	7	1	0	0	0	0	1	0	0	0	10432	933	33	1	3420	1	NISCH	3	52523592	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	198546	52523592	145498838	109	1578										
PRKCD	5580	broad.mit.edu	37	chr3	53212459	53212459	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atggcgccgttcctgcgcatCgccttcaactcctatgagct	9	15	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:53212459C>T	uc003dgl.2	+	3	374	c.21C>T	c.(19-21)ATC>ATT	p.I7I	PRKCD_uc003dgm.2_Silent_p.I7I|PRKCD_uc003dgn.2_Silent_p.I7I	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	7	C2.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		TCCTGCGCATCGCCTTCAACT	0.682													0	0	0	0.00308	0	6	42										T	53212459	C	T	53212459	2	4	7	1	0	0	0	0	0	0	0	1	12509	874	31	1		1	PRKCD	3	53212459	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	688867	53212459	144809971	110	1579										
PDZRN3	23024	broad.mit.edu	37	chr3	73438983	73438983	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttacctggataatgcggtctCcttctcggatgcgcccatcc	9	14	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:73438983C>T	uc003dpl.1	-	7	1496	c.1400G>A	c.(1399-1401)GGA>GAA	p.G467E	PDZRN3_uc011bgh.1_Missense_Mutation_p.G124E|PDZRN3_uc010hoe.1_Missense_Mutation_p.G165E|PDZRN3_uc011bgf.1_Missense_Mutation_p.G184E|PDZRN3_uc011bgg.1_Missense_Mutation_p.G187E	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	467	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		AATGCGGTCTCCTTCTCGGAT	0.468													0	0	0	0.001855	0	13	39										T	73438983	C	T	73438983	3	4	7	1	0	0	0	0	1	0	0	0	11709	855	30	1	1816	1	PDZRN3	3	73438983	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	20226524	73438983	124583447	111	1580										
CNTN3	5067	broad.mit.edu	37	chr3	74350684	74350684	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggctgtgtgcgtcttcccatCgatgacctcaggcactacaa	10	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:74350684C>A	uc003dpm.1	-	15	2040	c.1960G>T	c.(1960-1962)GAT>TAT	p.D654Y		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	654	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GTCTTCCCATCGATGACCTCA	0.443													1	0	0.004672	0.004672	0.00475469	3	71										A	74350684	C	A	74350684	3	1	7	1	0	0	0	0	1	0	0	0	3642	884	31	3	1158	3	CNTN3	3	74350684	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	911701	74350684	123671746	112	1581										
MYH15	22989	broad.mit.edu	37	chr3	108203941	108203941	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcaaagtaattcttactttCtgtgccatctgcttccagtt	5	10	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:108203941C>G	uc003dxa.1	-	12	1228	c.1171G>C	c.(1171-1173)GAA>CAA	p.E391Q		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	391	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTCTTACTTTCTGTGCCATCT	0.383													0	0	0	0.008871	0	19	48										G	108203941	C	G	108203941	3	3	7	1	0	0	0	0	1	0	0	0	10034	922	32	1	4793	1	MYH15	3	108203941	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	33853257	108203941	89818489	113	1582										
TMPRSS7	344805	broad.mit.edu	37	chr3	111769523	111769523	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggtatcttttccagagtgtGaaaacacagtgttggtcaaa	11	6	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:111769523G>A	uc010hqb.2	+	7	888	c.718G>A	c.(718-720)GAA>AAA	p.E240K	TMPRSS7_uc011bhr.1_Missense_Mutation_p.E95K	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	366	Extracellular (Potential).|CUB 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						TCCAGAGTGTGAAAACACAGT	0.398													0	0	0	0.002836	0	32	207										A	111769523	G	A	111769523	3	1	7	1	0	0	0	0	1	0	0	0	16249	1291	45	1	740	1	TMPRSS7	3	111769523	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3565582	111769523	86252907	114	1583										
CD200R1L	344807	broad.mit.edu	37	chr3	112546253	112546253	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tccacgatggaaattcccatCaggtgttaccactatgcctc	7	13	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:112546253C>T	uc003dzi.1	-	3	617	c.391G>A	c.(391-393)GAT>AAT	p.D131N	CD200R1L_uc011bhw.1_Missense_Mutation_p.D110N|CD200R1L_uc010hqf.1_Missense_Mutation_p.D110N	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	131	Ig-like V-type.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						AAATTCCCATCAGGTGTTACC	0.453													0	0	0	0.010504	0	20	90										T	112546253	C	T	112546253	3	4	7	1	0	0	0	0	1	0	0	0	2982	826	29	1	440	1	CD200R1L	3	112546253	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	776730	112546253	85476177	115	1584										
CD200R1L	344807	broad.mit.edu	37	chr3	112546398	112546398	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttggtctcatttgtttctttCttgtaggcttttgtgcagga	10	6	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:112546398C>T	uc003dzi.1	-	3	472	c.246G>A	c.(244-246)AAG>AAA	p.K82K	CD200R1L_uc011bhw.1_Silent_p.K61K|CD200R1L_uc010hqf.1_Silent_p.K61K	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	82	Ig-like V-type.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						TTGTTTCTTTCTTGTAGGCTT	0.438													0	0	0	0.001855	0	13	74										T	112546398	C	T	112546398	2	4	7	1	0	0	0	0	0	0	0	1	2982	912	32	1		1	CD200R1L	3	112546398	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	145	112546398	85476032	116	1585										
CCDC52	152185	broad.mit.edu	37	chr3	113172624	113172624	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agttttgttctccaaatcttCtcccatgtgagagactctcc	6	12	4	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:113172624C>T	uc003eag.3	-	14	2122	c.1831G>A	c.(1831-1833)GAA>AAA	p.E611K	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.E507K	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	611					cell division|mitosis	centriole|spindle	protein binding				0						TCCAAATCTTCTCCCATGTGA	0.438													0	0	0	0.002836	0	34	93										T	113172624	C	T	113172624	3	4	7	1	0	0	0	0	1	0	0	0	2822	922	32	1	756	1	CCDC52	3	113172624	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	626226	113172624	84849806	117	1586										
ATP6V1A	523	broad.mit.edu	37	chr3	113528247	113528247	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caacttcttgaagacatgcaGaatgcattccgtagccttga	8	10	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:113528247G>A	uc003eao.2	+	15	1893	c.1827G>A	c.(1825-1827)CAG>CAA	p.Q609Q	ATP6V1A_uc011bik.1_Silent_p.Q576Q	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	609					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						AAGACATGCAGAATGCATTCC	0.393													0	0	0	0.001984	0	7	48										A	113528247	G	A	113528247	2	1	7	1	0	0	0	0	0	0	0	1	1177	933	33	1		1	ATP6V1A	3	113528247	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	355623	113528247	84494183	118	1587										
POLQ	10721	broad.mit.edu	37	chr3	121206874	121206874	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtcctggacttagatcaaatGatgcccctgaccatatgaat	8	10	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:121206874G>C	uc003eee.3	-	16	5033	c.4904C>G	c.(4903-4905)TCA>TGA	p.S1635*	POLQ_uc003eed.2_Nonsense_Mutation_p.S807*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1635					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TAGATCAAATGATGCCCCTGA	0.373								DNA_polymerases_(catalytic_subunits)					0	0	0	0.00361	0	63	166										C	121206874	G	C	121206874	4	2	7	1	0	0	0	0	0	1	0	0	12208	1294	45	1	2928	1	POLQ	3	121206874	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7678627	121206874	76815556	119	1588										
GOLGB1	2804	broad.mit.edu	37	chr3	121411306	121411306	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagaactgtggtataggtggCgtgtctcttctagctgggac	15	7	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:121411306C>T	uc003eei.3	-	14	7016	c.6890G>A	c.(6889-6891)CGC>CAC	p.R2297H	GOLGB1_uc010hrc.2_Missense_Mutation_p.R2302H|GOLGB1_uc003eej.3_Missense_Mutation_p.R2263H	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2297	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		GTATAGGTGGCGTGTCTCTTC	0.433													0	0	0	0.001855	0	13	90										T	121411306	C	T	121411306	3	4	7	1	0	0	0	0	1	0	0	0	6565	768	27	2	2925	2	GOLGB1	3	121411306	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	204432	121411306	76611124	120	1589										
ILDR1	286676	broad.mit.edu	37	chr3	121725918	121725918	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccacgtcctggagctgggcaGaggtggtgtagtcacatttg	15	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:121725918G>A	uc003ees.2	-	2	255	c.149C>T	c.(148-150)TCT>TTT	p.S50F	ILDR1_uc003eeq.2_Missense_Mutation_p.S62F|ILDR1_uc003eer.2_Missense_Mutation_p.S50F|ILDR1_uc010hrg.2_Missense_Mutation_p.S50F	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	50	Extracellular (Potential).|Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		GAGCTGGGCAGAGGTGGTGTA	0.527													0	0	0	0.008291	0	9	58										A	121725918	G	A	121725918	3	1	7	1	0	0	0	0	1	0	0	0	7709	942	33	1	1383	1	ILDR1	3	121725918	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	314612	121725918	76296512	121	1590										
RUVBL1	8607	broad.mit.edu	37	chr3	127831851	127831851	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagctcctgagcaatagccaGagccagagctgtctacaaaa	9	12	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:127831851G>A	uc003ekh.2	-	3	345	c.241C>T	c.(241-243)CTG>TTG	p.L81L	RUVBL1_uc003ekf.2_Silent_p.L21L|RUVBL1_uc010hss.2_Silent_p.L81L	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	81					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		GCAATAGCCAGAGCCAGAGCT	0.483													0	0	0	0.004482	0	9	82										A	127831851	G	A	127831851	2	1	7	1	0	0	0	0	0	0	0	1	13752	933	33	1		1	RUVBL1	3	127831851	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6105933	127831851	70190579	122	1591										
MRPL3	11222	broad.mit.edu	37	chr3	131217033	131217033	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acatccttacacgaaaacgtGatacagtttttcctcctaca	4	12	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:131217033G>A	uc003eoh.2	-	4	622	c.458C>T	c.(457-459)TCA>TTA	p.S153L	MRPL3_uc011blo.1_Missense_Mutation_p.S48L|MRPL3_uc011blp.1_Missense_Mutation_p.S180L	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	153					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						ACGAAAACGTGATACAGTTTT	0.348													0	0	0	0.008871	0	18	71										A	131217033	G	A	131217033	3	1	7	1	0	0	0	0	1	0	0	0	9793	1294	45	1	616	1	MRPL3	3	131217033	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3385182	131217033	66805397	123	1592										
TF	7018	broad.mit.edu	37	chr3	133494392	133494392	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aactgccacctggccagagcCccgaatcacgctgtggtcac	10	16	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:133494392C>T	uc003epu.1	+	20	3531	c.1803C>T	c.(1801-1803)GCC>GCT	p.A601A	TF_uc011blt.1_Silent_p.A474A|TF_uc003epw.1_Silent_p.T40T|TF_uc003epv.1_Silent_p.A601A	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	601	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	TGGCCAGAGCCCCGAATCACG	0.512													0	0	0	0.001855	0	13	179										T	133494392	C	T	133494392	2	4	7	1	0	0	0	0	0	0	0	1	15782	610	22	2		2	TF	3	133494392	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2277359	133494392	64528038	124	1593										
ATR	545	broad.mit.edu	37	chr3	142188970	142188970	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtaccataatcaagccataGagttaacattcgtggcattg	8	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:142188970G>C	uc003eux.3	-	37	6399	c.6277C>G	c.(6277-6279)CTA>GTA	p.L2093V	ATR_uc003euy.1_5'Flank	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2093	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TCAAGCCATAGAGTTAACATT	0.318								Other_conserved_DNA_damage_response_genes					0	0	0	0.009096	0	4	22										C	142188970	G	C	142188970	3	2	7	1	0	0	0	0	1	0	0	0	1204	933	33	1	1701	1	ATR	3	142188970	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8694578	142188970	55833460	125	1594										
ZIC1	7545	broad.mit.edu	37	chr3	147131226	147131226	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cacgcctcccaccatcgtgtCtccctccacagacaacccga	5	21	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:147131226C>T	uc003ewe.2	+	3	1951	c.1232C>T	c.(1231-1233)TCT>TTT	p.S411F		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	411	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACCATCGTGTCTCCCTCCACA	0.607													0	0	0	0.010729	0	11	72										T	147131226	C	T	147131226	3	4	7	1	0	0	0	0	1	0	0	0	17675	913	32	1	1242	1	ZIC1	3	147131226	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4942256	147131226	50891204	126	1595										
IGSF10	285313	broad.mit.edu	37	chr3	151163978	151163978	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagcggtagtcaaggtattaGatggaatttgcatcacactt	11	6	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:151163978G>C	uc011bod.1	-	4	3791	c.3791C>G	c.(3790-3792)TCT>TGT	p.S1264C		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1264					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAAGGTATTAGATGGAATTTG	0.458													0	0	0	0.00333	0	24	114										C	151163978	G	C	151163978	3	2	7	1	0	0	0	0	1	0	0	0	7597	942	33	1	4140	1	IGSF10	3	151163978	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4032752	151163978	46858452	127	1596										
IGSF10	285313	broad.mit.edu	37	chr3	151164002	151164002	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaatttgcatcacacttgttGaaagtgtggtgaaatggaaa	11	4	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:151164002G>A	uc011bod.1	-	4	3767	c.3767C>T	c.(3766-3768)TCA>TTA	p.S1256L		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1256					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CACACTTGTTGAAAGTGTGGT	0.418													0	0	0	0.00333	0	23	123										A	151164002	G	A	151164002	3	1	7	1	0	0	0	0	1	0	0	0	7597	1294	45	1	4164	1	IGSF10	3	151164002	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	24	151164002	46858428	128	1597										
PLCH1	23007	broad.mit.edu	37	chr3	155232674	155232674	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgctcagtggtcccattactCtgcaaagaattaagtaacac	7	10	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:155232674C>G	uc011bok.1	-	11	1712	c.1435_splice	c.e11-1	p.S479_splice	PLCH1_uc011boj.1_Splice_Site_p.S479_splice|PLCH1_uc011bol.1_Splice_Site_p.S461_splice	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a						lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCCATTACTCTGCAAAGAAT	0.348													0	0	0	0.000602	0	5	36										G	155232674	C	G	155232674	5	3	7	1	0	0	0	0	0	0	1	0	12037	927	32	1	3714	1	PLCH1	3	155232674	Splice_Site	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4068672	155232674	42789756	129	1598										
GFM1	85476	broad.mit.edu	37	chr3	158383171	158383171	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtattggcaggtttacaagaGaagatcccacatttaaagta	9	6	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:158383171G>C	uc003fce.2	+	12	1533	c.1426G>C	c.(1426-1428)GAA>CAA	p.E476Q	GFM1_uc003fcd.2_Missense_Mutation_p.E476Q|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Missense_Mutation_p.E407Q	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	476					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GTTTACAAGAGAAGATCCCAC	0.348													0	0	0	0.006214	0	8	36										C	158383171	G	C	158383171	3	2	7	1	0	0	0	0	1	0	0	0	6341	943	33	1	1472	1	GFM1	3	158383171	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3150497	158383171	39639259	130	1599										
GFM1	85476	broad.mit.edu	37	chr3	158384153	158384153	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agccaaaagttgcctttcgaGagaccattactgcccctgtc	8	13	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:158384153G>T	uc003fce.2	+	13	1686	c.1579G>T	c.(1579-1581)GAG>TAG	p.E527*	GFM1_uc003fcd.2_Nonsense_Mutation_p.E527*|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Nonsense_Mutation_p.E458*	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	527					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TGCCTTTCGAGAGACCATTAC	0.358													1	0	8.12818e-05	0.001984	8.35834e-05	7	31										T	158384153	G	T	158384153	4	4	7	1	0	0	0	0	0	1	0	0	6341	943	33	3	1629	3	GFM1	3	158384153	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	982	158384153	39638277	131	1600										
WDR49	151790	broad.mit.edu	37	chr3	167245664	167245664	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtcacacaaatactgcagtCtgcagaggaggagataatca	10	8	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:167245664C>T	uc003fev.1	-	11	1798	c.1492G>A	c.(1492-1494)GAC>AAC	p.D498N	WDR49_uc003feu.1_Missense_Mutation_p.D323N|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	498	WD 8.									large_intestine(1)|ovary(1)|skin(1)	3						ATACTGCAGTCTGCAGAGGAG	0.413													0	0	0	0.000602	0	5	25										T	167245664	C	T	167245664	3	4	7	1	0	0	0	0	1	0	0	0	17299	913	32	1	621	1	WDR49	3	167245664	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	8861511	167245664	30776766	132	1601										
PDCD10	11235	broad.mit.edu	37	chr3	167414891	167414891	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcataatgatgtcttgtgtGagacctggattttctttttc	8	6	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:167414891G>A	uc003fex.2	-	5	572	c.174C>T	c.(172-174)CTC>CTT	p.L58L	PDCD10_uc003fez.2_Silent_p.L58L|PDCD10_uc003fey.2_Silent_p.L58L	NM_007217	NP_009148	Q9BUL8	PDC10_HUMAN	programmed cell death 10	58					angiogenesis|apoptosis|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of MAP kinase activity	cytosol|Golgi membrane|plasma membrane	protein homodimerization activity|protein N-terminus binding			lung(1)|central_nervous_system(1)	2						TGTCTTGTGTGAGACCTGGAT	0.333									Familial_Cerebral_Cavernous_Angioma				0	0	0	0.006214	0	10	42										A	167414891	G	A	167414891	2	1	7	1	0	0	0	0	0	0	0	1	11616	1277	45	1		1	PDCD10	3	167414891	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	169227	167414891	30607539	133	1602										
SKIL	6498	broad.mit.edu	37	chr3	170108952	170108952	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaagaattttatgttgaacaGaaagacttagagaaaaaatt	8	2	0	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:170108952G>C	uc003fgu.2	+	6	2512	c.1800G>C	c.(1798-1800)CAG>CAC	p.Q600H	SKIL_uc011bps.1_Missense_Mutation_p.Q580H|SKIL_uc003fgv.2_Missense_Mutation_p.Q554H|SKIL_uc003fgw.2_Missense_Mutation_p.Q600H	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	600	Potential.				cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			ATGTTGAACAGAAAGACTTAG	0.348													0	0	0	0.001984	0	7	52										C	170108952	G	C	170108952	3	2	7	1	0	0	0	0	1	0	0	0	14358	933	33	1	1818	1	SKIL	3	170108952	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2694061	170108952	27913478	134	1603										
EIF2B5	8893	broad.mit.edu	37	chr3	183860565	183860565	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcacccattatggcttctcAggactcaagatcaacatgga	7	12	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:183860565A>C	uc003fmp.2	+	11	1911	c.1547_splice	c.e11-2	p.G516_splice	EIF2B5_uc003fmq.2_Splice_Site_p.G237_splice|EIF2B5_uc003fmr.2_5'Flank	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,						astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATGGCTTCTCAGGACTCAAGA	0.458													0	0	0	0.001168	0	6	13										C	183860565	A	C	183860565	5	2	7	1	0	0	0	0	0	0	1	0	5004	202	7	5	1587	5	EIF2B5	3	183860565	Splice_Site	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	13751613	183860565	14161865	135	1604										
VPS8	23355	broad.mit.edu	37	chr3	184570306	184570306	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtttacagatgatccaactCttgcaatttgcaacgacagc	7	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:184570306C>G	uc003fpb.1	+	10	937	c.766C>G	c.(766-768)CTT>GTT	p.L256V	VPS8_uc010hyd.1_Missense_Mutation_p.L256V	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	258							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TGATCCAACTCTTGCAATTTG	0.313													0	0	0	0.009096	0	4	35										G	184570306	C	G	184570306	3	3	7	1	0	0	0	0	1	0	0	0	17215	913	32	1	806	1	VPS8	3	184570306	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	709741	184570306	13452124	136	1605										
MAP3K13	9175	broad.mit.edu	37	chr3	185191489	185191489	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtaggtctgagtcatccctCggcacctctcatctcggcac	9	15	4	1	rs148543279	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:185191489C>T	uc010hyf.2	+	12	2636	c.2370C>T	c.(2368-2370)CTC>CTT	p.L790L	MAP3K13_uc011brt.1_Silent_p.L583L|MAP3K13_uc011bru.1_Silent_p.L646L|MAP3K13_uc003fpi.2_Silent_p.L790L|MAP3K13_uc010hyg.2_Silent_p.L480L	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	790					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGTCATCCCTCGGCACCTCTC	0.512													0	0	0	0.00361	0	44	132										T	185191489	C	T	185191489	2	4	7	1	0	0	0	0	0	0	0	1	9247	871	31	1		1	MAP3K13	3	185191489	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	621183	185191489	12830941	137	1606										
HRG	3273	broad.mit.edu	37	chr3	186395041	186395041	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acccccacttccacaaggccCtcctccactattgcccatgt	4	20	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:186395041C>T	uc003fqq.2	+	7	970	c.947C>T	c.(946-948)CCT>CTT	p.P316L		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	316	Pro-rich.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CCACAAGGCCCTCCTCCACTA	0.493													0	0	0	0.001855	0	13	70										T	186395041	C	T	186395041	3	4	7	1	0	0	0	0	1	0	0	0	7354	681	24	2	973	2	HRG	3	186395041	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1203552	186395041	11627389	138	1607										
C3orf21	152002	broad.mit.edu	37	chr3	194790491	194790491	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gttcccgtggtagatcttgaCgtggccctcacacctgaaat	10	12	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:194790491C>T	uc003fum.3	-	4	1243	c.1135G>A	c.(1135-1137)GTC>ATC	p.V379I	C3orf21_uc003ful.2_Missense_Mutation_p.V176I|C3orf21_uc003fuk.2_Missense_Mutation_p.V173I	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	379						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		TAGATCTTGACGTGGCCCTCA	0.627													0	0	0	0.001855	0	12	101										T	194790491	C	T	194790491	3	4	7	1	0	0	0	0	1	0	0	0	2214	536	19	2	50	2	C3orf21	3	194790491	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	8395450	194790491	3231939	139	1608										
LRCH3	84859	broad.mit.edu	37	chr3	197593030	197593030	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgctgctatccagagaaatCagcctcagcgccctgaaagc	9	14	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr3:197593030C>G	uc011bul.1	+	17	1818	c.1813C>G	c.(1813-1815)CAG>GAG	p.Q605E	LRCH3_uc003fyj.1_Missense_Mutation_p.Q605E|LRCH3_uc011bum.1_Missense_Mutation_p.Q553E|LRCH3_uc011bun.1_Missense_Mutation_p.Q451E|LRCH3_uc003fyk.2_Missense_Mutation_p.Q200E	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	605						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		CCAGAGAAATCAGCCTCAGCG	0.433													0	0	0	0.00245	0	11	83										G	197593030	C	G	197593030	3	3	7	1	0	0	0	0	1	0	0	0	8934	827	29	1	1879	1	LRCH3	3	197593030	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2802539	197593030	429400	140	1609										
ZNF721	170960	broad.mit.edu	37	chr4	435805	435805	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agggttgtggaactagtaaaCgctttaccacattctaaaca	8	8	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:435805C>T	uc003gag.2	-	3	3142	c.2451G>A	c.(2449-2451)GCG>GCA	p.A817A	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Silent_p.A849A|ZNF721_uc010ibe.2_Silent_p.A805A	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	817						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AACTAGTAAACGCTTTACCAC	0.393													0	0	0	0.00245	0	12	44										T	435805	C	T	435805	2	4	7	1	0	0	0	0	0	0	0	1	18119	523	19	2		2	ZNF721	4	435805	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08		435805	190718471	141	1610										
KIAA1530	57654	broad.mit.edu	37	chr4	1347183	1347183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctcgcacaagtacacgctgGatgtggagctctgctcaggt	13	11	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:1347183G>A	uc003gde.3	+	5	1363	c.916G>A	c.(916-918)GAT>AAT	p.D306N		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	306											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GTACACGCTGGATGTGGAGCT	0.667													0	0	0	0.009096	0	4	5										A	1347183	G	A	1347183	3	1	7	1	0	0	0	0	1	0	0	0	8241	1174	41	1	930	1	KIAA1530	4	1347183	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	911378	1347183	189807093	142	1611										
MSX1	4487	broad.mit.edu	37	chr4	4864675	4864675	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcagagctggagaagctgaaGatggccgccaagcccatgct	14	11	0	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:4864675G>C	uc003gif.2	+	2	952	c.717G>C	c.(715-717)AAG>AAC	p.K239N		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	233					apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		AGAAGCTGAAGATGGCCGCCA	0.657													0	0	0	0.004482	0	7	26										C	4864675	G	C	4864675	3	2	7	1	0	0	0	0	1	0	0	0	9895	933	33	1	723	1	MSX1	4	4864675	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3517492	4864675	186289601	143	1612										
SEL1L3	23231	broad.mit.edu	37	chr4	25789920	25789920	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggcgcccttggcgtaccactCaattgctgcttcgggattct	11	13	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:25789920C>G	uc003gru.3	-	13	2295	c.2143G>C	c.(2143-2145)GAG>CAG	p.E715Q	SEL1L3_uc003grv.2_Missense_Mutation_p.E122Q	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	715	Sel1-like 3.					integral to membrane	binding				0						GCGTACCACTCAATTGCTGCT	0.468													0	0	0	0.003163	0	15	87										G	25789920	C	G	25789920	3	3	7	1	0	0	0	0	1	0	0	0	14012	835	29	1	1303	1	SEL1L3	4	25789920	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	20925245	25789920	165364356	144	1613										
TLR10	81793	broad.mit.edu	37	chr4	38776503	38776503	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cttagcattttctaaactaaGatttcgttgcatttcataac	4	8	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:38776503G>C	uc003gti.2	-	2	1088	c.709C>G	c.(709-711)CTT>GTT	p.L237V	TLR10_uc003gtj.2_Missense_Mutation_p.L237V|TLR10_uc003gtk.2_Missense_Mutation_p.L237V	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	237	Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						TCTAAACTAAGATTTCGTTGC	0.328													0	0	0	0.003163	0	14	24										C	38776503	G	C	38776503	3	2	7	1	0	0	0	0	1	0	0	0	15947	942	33	1	1730	1	TLR10	4	38776503	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	12986583	38776503	152377773	145	1614										
RFC1	5981	broad.mit.edu	37	chr4	39308303	39308303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tagagccatcatctttgccgGaaaatttaccaaactttgct	6	10	2	1	rs55727832		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:39308303G>A	uc003gty.1	-	14	2041	c.1907C>T	c.(1906-1908)TCC>TTC	p.S636F	RFC1_uc003gtx.1_Missense_Mutation_p.S635F	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	636					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						ATCTTTGCCGGAAAATTTACC	0.458													0	0	0	0.004482	0	9	25										A	39308303	G	A	39308303	3	1	7	1	0	0	0	0	1	0	0	0	13244	1174	41	1	1587	1	RFC1	4	39308303	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	531800	39308303	151845973	146	1615										
CXCL13	10563	broad.mit.edu	37	chr4	78527049	78527049	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atctcgacatctctgcttctCatgctgctggtcagcagcct	8	14	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:78527049C>T	uc003hkr.2	+	2	108	c.30C>T	c.(28-30)CTC>CTT	p.L10L		NM_006419	NP_006410	O43927	CXL13_HUMAN	chemokine (C-X-C motif) ligand 13 (B-cell	10					activation of Rap GTPase activity|B cell chemotaxis|cell-cell signaling|chronic inflammatory response|defense response to bacterium|elevation of cytosolic calcium ion concentration|endothelial cell chemotaxis to fibroblast growth factor|germinal center formation|lymphocyte chemotaxis across high endothelial venule|negative regulation of apoptosis|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of integrin activation|positive regulation of T cell chemotaxis|regulation of angiogenesis|regulation of humoral immune response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|CXCR3 chemokine receptor binding|CXCR5 chemokine receptor binding|fibroblast growth factor 2 binding|heparin binding|protein heterodimerization activity|receptor agonist activity				0						CTCTGCTTCTCATGCTGCTGG	0.443													0	0	0	0.004482	0	8	48										T	78527049	C	T	78527049	2	4	7	1	0	0	0	0	0	0	0	1	4081	813	29	1		1	CXCL13	4	78527049	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	39218746	78527049	112627227	147	1616										
WDFY3	23001	broad.mit.edu	37	chr4	85662946	85662946	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgaattataaaatctataaGaagtttagattctttgttga	6	2	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:85662946G>C	uc003hpd.2	-	38	6610	c.6202C>G	c.(6202-6204)CTT>GTT	p.L2068V		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2068						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AAATCTATAAGAAGTTTAGAT	0.368													0	0	0	0.008291	0	11	66										C	85662946	G	C	85662946	3	2	7	1	0	0	0	0	1	0	0	0	17267	942	33	1	4502	1	WDFY3	4	85662946	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7135897	85662946	105491330	148	1617										
ARHGAP24	83478	broad.mit.edu	37	chr4	86893235	86893235	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cacttcttaagctgtacctcCgagaacttccagaaccagtt	6	13	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:86893235C>T	uc003hpk.2	+	6	1095	c.646C>T	c.(646-648)CGA>TGA	p.R216*	ARHGAP24_uc003hpj.2_Nonsense_Mutation_p.R216*|ARHGAP24_uc003hpl.2_Nonsense_Mutation_p.R121*|ARHGAP24_uc010ikf.2_Nonsense_Mutation_p.R131*|ARHGAP24_uc003hpm.2_Nonsense_Mutation_p.R123*	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	216	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		GCTGTACCTCCGAGAACTTCC	0.418													0	0	0	0.001368	0	11	43										T	86893235	C	T	86893235	4	4	7	1	0	0	0	0	0	1	0	0	873	644	23	2	780	2	ARHGAP24	4	86893235	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1230289	86893235	104261041	149	1618										
SMARCAD1	56916	broad.mit.edu	37	chr4	95155124	95155124	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gttctgagccatctgaagatGaagagtcccaaggccttcct	10	11	2	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:95155124G>C	uc003htc.3	+	4	643	c.388G>C	c.(388-390)GAA>CAA	p.E130Q	SMARCAD1_uc003htb.3_Missense_Mutation_p.E130Q|SMARCAD1_uc003htd.3_Missense_Mutation_p.E130Q|SMARCAD1_uc010ila.2_5'UTR	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	130					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		ATCTGAAGATGAAGAGTCCCA	0.274													0	0	0	0.001168	0	6	37										C	95155124	G	C	95155124	3	2	7	1	0	0	0	0	1	0	0	0	14772	1291	45	1	398	1	SMARCAD1	4	95155124	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8261889	95155124	95999152	150	1619										
RG9MTD2	93587	broad.mit.edu	37	chr4	100479303	100479303	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gttttctgtcatgtccatctGagtttggttccatttgacat	8	8	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:100479303G>C	uc003huy.2	-	3	564	c.251C>G	c.(250-252)TCA>TGA	p.S84*	RG9MTD2_uc003huz.3_Nonsense_Mutation_p.S84*|RG9MTD2_uc003hva.3_Nonsense_Mutation_p.S84*	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	84							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		ATGTCCATCTGAGTTTGGTTC	0.338													0	0	0	0.00308	0	8	47										C	100479303	G	C	100479303	4	2	7	1	0	0	0	0	0	1	0	0	13272	1294	45	1	792	1	RG9MTD2	4	100479303	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5324179	100479303	90674973	151	1620										
BANK1	55024	broad.mit.edu	37	chr4	102981490	102981490	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaatgtctatggatgaagctCtggagaaatttaaacactgg	10	5	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:102981490C>G	uc003hvy.3	+	12	2366	c.2092C>G	c.(2092-2094)CTG>GTG	p.L698V	BANK1_uc003hvx.3_Missense_Mutation_p.L683V|BANK1_uc010ill.2_Missense_Mutation_p.L565V|BANK1_uc003hvz.3_Missense_Mutation_p.L668V	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	698					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GGATGAAGCTCTGGAGAAATT	0.453													0	0	0	0.000602	0	4	63										G	102981490	C	G	102981490	3	3	7	1	0	0	0	0	1	0	0	0	1309	912	32	1	2138	1	BANK1	4	102981490	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2502187	102981490	88172786	152	1621										
BDH2	56898	broad.mit.edu	37	chr4	104013836	104013836	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttcttctttgtgacatcaaGgacacgagtttgaatacctg	8	8	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:104013836G>A	uc003hwz.2	-	4	274	c.169C>T	c.(169-171)CTT>TTT	p.L57F	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	57					fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		GTGACATCAAGGACACGAGTT	0.338													0	0	0	0.009096	0	4	9										A	104013836	G	A	104013836	3	1	7	1	0	0	0	0	1	0	0	0	1391	1000	35	2	596	2	BDH2	4	104013836	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1032346	104013836	87140440	153	1622										
INTS12	57117	broad.mit.edu	37	chr4	106614616	106614616	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctaggtttctttggaatatCaactccttcagtgatgtctg	8	8	5	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:106614616C>G	uc003hxw.2	-	5	595	c.337G>C	c.(337-339)GAT>CAT	p.D113H	INTS12_uc010ilr.2_Missense_Mutation_p.D113H	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	113					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TTTGGAATATCAACTCCTTCA	0.373													0	0	0	0.003271	0	36	114										G	106614616	C	G	106614616	3	3	7	1	0	0	0	0	1	0	0	0	7777	826	29	1	1067	1	INTS12	4	106614616	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2600780	106614616	84539660	154	1623										
EGF	1950	broad.mit.edu	37	chr4	110882118	110882118	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgtgccctgtaggatttgttCtgcttcctgatgggaaacga	12	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:110882118C>T	uc003hzy.3	+	7	1614	c.1162C>T	c.(1162-1164)CTG>TTG	p.L388L	EGF_uc011cfu.1_Silent_p.L346L|EGF_uc011cfv.1_Silent_p.L388L	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	388	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AGGATTTGTTCTGCTTCCTGA	0.388													0	0	0	0.001855	0	12	54										T	110882118	C	T	110882118	2	4	7	1	0	0	0	0	0	0	0	1	4962	912	32	1		1	EGF	4	110882118	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4267502	110882118	80272158	155	1624										
ALPK1	80216	broad.mit.edu	37	chr4	113362208	113362208	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taataaccagcatgtggaatGtaatgaaatctgccatcgtc	8	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:113362208G>A	uc003iap.3	+	15	3953	c.3674G>A	c.(3673-3675)TGT>TAT	p.C1225Y	ALPK1_uc003ian.3_Missense_Mutation_p.C1225Y|ALPK1_uc011cfx.1_Missense_Mutation_p.C1147Y|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.C1053Y	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1225	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CATGTGGAATGTAATGAAATC	0.383													0	0	0	0.00499	0	16	132										A	113362208	G	A	113362208	3	1	7	1	0	0	0	0	1	0	0	0	544	1377	48	2	3724	2	ALPK1	4	113362208	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2480090	113362208	77792068	156	1625										
PRDM5	11107	broad.mit.edu	37	chr4	121738027	121738027	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agaattgcaaacagagcactGaaaacttcgcgaagactcct	8	10	0	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:121738027G>A	uc003idn.2	-	6	953	c.703C>T	c.(703-705)CAG>TAG	p.Q235*	PRDM5_uc003ido.2_Intron|PRDM5_uc010ine.2_Intron|PRDM5_uc010inf.2_Intron	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	235	C2H2-type 3; atypical.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						ACAGAGCACTGAAAACTTCGC	0.378													0	0	0	0.004289	0	31	165										A	121738027	G	A	121738027	4	1	7	1	0	0	0	0	0	1	0	0	12460	1299	45	1	1233	1	PRDM5	4	121738027	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8375819	121738027	69416249	157	1626										
PCDH10	57575	broad.mit.edu	37	chr4	134072563	134072563	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taccgaagcccccctggaccGagaggcgggggactcctaca	13	15	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:134072563G>A	uc003iha.2	+	1	2094	c.1268G>A	c.(1267-1269)CGA>CAA	p.R423Q	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.R423Q	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	423	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCCCTGGACCGAGAGGCGGGG	0.592													0	0	0	0.006999	0	34	155										A	134072563	G	A	134072563	3	1	7	1	0	0	0	0	1	0	0	0	11507	1058	37	1	1270	1	PCDH10	4	134072563	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	12334536	134072563	57081713	158	1627										
FGA	2243	broad.mit.edu	37	chr4	155507837	155507837	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggcatgtctgttaatgccttCcactctgggggtaccttctg	11	11	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:155507837C>G	uc003iod.1	-	5	802	c.744G>C	c.(742-744)TGG>TGC	p.W248C	FGA_uc003ioe.1_Missense_Mutation_p.W248C|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	248	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTAATGCCTTCCACTCTGGGG	0.473													0	0	0	0.006214	0	10	77										G	155507837	C	G	155507837	3	3	7	1	0	0	0	0	1	0	0	0	5830	856	30	1	1908	1	FGA	4	155507837	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	21435274	155507837	35646439	159	1628										
DDX60	55601	broad.mit.edu	37	chr4	169208323	169208323	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagagatattcataatctttCataatggtatctcccaaatt	4	8	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:169208323C>T	uc003irp.2	-	10	1507	c.1215G>A	c.(1213-1215)ATG>ATA	p.M405I		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	405							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CATAATCTTTCATAATGGTAT	0.353													0	0	0	0.001168	0	5	28										T	169208323	C	T	169208323	3	4	7	1	0	0	0	0	1	0	0	0	4378	826	29	1	4039	1	DDX60	4	169208323	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	13700486	169208323	21945953	160	1629										
ODZ3	55714	broad.mit.edu	37	chr4	183664474	183664474	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagttactggccccagtggcGctagcttgtgggatcgatgg	15	9	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:183664474G>A	uc003ivd.1	+	18	3568	c.3531G>A	c.(3529-3531)GCG>GCA	p.A1177A	ODZ3_uc003ive.1_Silent_p.A583A	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1177	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CCCCAGTGGCGCTAGCTTGTG	0.512													0	0	0	0.008291	0	10	44										A	183664474	G	A	183664474	2	1	7	1	0	0	0	0	0	0	0	1	10836	1074	38	2		2	ODZ3	4	183664474	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	14456151	183664474	7489802	161	1630										
C4orf41	60684	broad.mit.edu	37	chr4	184614842	184614842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgtgactgttcagtcccatGaaaagacccaaatcagagat	8	9	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr4:184614842G>A	uc003ivx.2	+	21	2514	c.2338G>A	c.(2338-2340)GAA>AAA	p.E780K	C4orf41_uc003ivw.2_Missense_Mutation_p.E780K|C4orf41_uc010isc.2_Missense_Mutation_p.E124K|C4orf41_uc003ivy.2_Missense_Mutation_p.E386K	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	780											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		TCAGTCCCATGAAAAGACCCA	0.393													0	0	0	0.004878	0	37	89										A	184614842	G	A	184614842	3	1	7	1	0	0	0	0	1	0	0	0	2270	1291	45	1	2416	1	C4orf41	4	184614842	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	950368	184614842	6539434	162	1631										
SLC12A7	10723	broad.mit.edu	37	chr5	1076837	1076837	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatcggggccacgctgtccaGagaggcgatgaggatgccag	17	10	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:1076837G>A	uc003jbu.2	-	13	1786	c.1720C>T	c.(1720-1722)CTG>TTG	p.L574L		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	574	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ACGCTGTCCAGAGAGGCGATG	0.667													0	0	0	0.001168	0	6	21										A	1076837	G	A	1076837	2	1	7	1	0	0	0	0	0	0	0	1	14388	933	33	1		1	SLC12A7	5	1076837	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		1076837	179838423	163	1632										
ADAMTS16	170690	broad.mit.edu	37	chr5	5235258	5235258	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcacaacagcagacgattcaGagggcggcactacaagtgga	13	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:5235258G>C	uc003jdl.2	+	13	2120	c.1982G>C	c.(1981-1983)AGA>ACA	p.R661T	ADAMTS16_uc003jdk.1_Missense_Mutation_p.R661T|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	661	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGACGATTCAGAGGGCGGCAC	0.483													0	0	0	0.001855	0	13	35										C	5235258	G	C	5235258	3	2	7	1	0	0	0	0	1	0	0	0	261	942	33	1	2032	1	ADAMTS16	5	5235258	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4158421	5235258	175680002	164	1633										
KIAA0947	23379	broad.mit.edu	37	chr5	5476188	5476188	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atagcctcaatactgaggctGattggtaagttgtctgtttt	10	6	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:5476188G>C	uc003jdm.3	+	17	6738	c.6516G>C	c.(6514-6516)CTG>CTC	p.L2172L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2172										ovary(1)|central_nervous_system(1)	2						TACTGAGGCTGATTGGTAAGT	0.353													0	0	0	0.004672	0	3	10										C	5476188	G	C	5476188	2	2	7	1	0	0	0	0	0	0	0	1	8202	1277	45	1		1	KIAA0947	5	5476188	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	240930	5476188	175439072	165	1634										
TRIO	7204	broad.mit.edu	37	chr5	14472765	14472765	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggaccttggctatgtggttGaggtgtgtattgccagaaat	15	5	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:14472765G>A	uc003jff.2	+	39	5983	c.5977G>A	c.(5977-5979)GAG>AAG	p.E1993K	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.E1642K	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1993	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CTATGTGGTTGAGGTGTGTAT	0.393													0	0	0	0.00499	0	15	62										A	14472765	G	A	14472765	3	1	7	1	0	0	0	0	1	0	0	0	16549	1291	45	1	6131	1	TRIO	5	14472765	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8996577	14472765	166442495	166	1635										
RAD1	5810	broad.mit.edu	37	chr5	34913668	34913668	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcttcctgaactttaaactCctgaaatattccagcctatg	4	12	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:34913668C>T	uc003jix.2	-	3	543	c.214G>A	c.(214-216)GAG>AAG	p.E72K	RAD1_uc003jiw.2_Intron|RAD1_uc003jiy.2_Missense_Mutation_p.E72K|BRIX1_uc003jiz.2_5'Flank|BRIX1_uc011col.1_5'Flank|BRIX1_uc003jja.2_5'Flank	NM_002853	NP_002844	O60671	RAD1_HUMAN	RAD1 homolog	72					DNA damage checkpoint|DNA repair|DNA replication|meiotic prophase I	nucleoplasm	3'-5' exonuclease activity|damaged DNA binding|exodeoxyribonuclease III activity|protein binding				0	all_lung(31;0.000107)	Lung NSC(810;5.19e-05)|Ovarian(839;0.0448)|Breast(839;0.198)	COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			ACTTTAAACTCCTGAAATATT	0.284								Other_conserved_DNA_damage_response_genes					0	0	0	0.001855	0	12	32										T	34913668	C	T	34913668	3	4	7	1	0	0	0	0	1	0	0	0	12978	864	30	1	650	1	RAD1	5	34913668	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	20440903	34913668	146001592	167	1636										
NUP155	9631	broad.mit.edu	37	chr5	37371030	37371030	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccagagcttcctgcagggctGcggcagatgtagaggccggc	16	12	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:37371030G>A	uc003jku.1	-	1	168	c.50C>T	c.(49-51)GCA>GTA	p.A17V	NUP155_uc003jkt.1_5'Flank|NUP155_uc010iuz.1_Missense_Mutation_p.A17V	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	17					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTGCAGGGCTGCGGCAGATGT	0.557													0	0	0	0.010729	0	11	55										A	37371030	G	A	37371030	3	1	7	1	0	0	0	0	1	0	0	0	10756	1319	46	2	4265	2	NUP155	5	37371030	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2457362	37371030	143544230	168	1637										
NUP155	9631	broad.mit.edu	37	chr5	37371140	37371140	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accaaggagaaacaagaaaaGatccaagaagttagcttaga	9	6	0	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:37371140G>C	uc003jku.1	-	1	58	c.-60C>G	c.(-62--58)ATCTT>ATGTT		NUP155_uc003jkt.1_5'Flank|NUP155_uc010iuz.1_Translation_Start_Site	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AACAAGAAAAGATCCAAGAAG	0.567													0	0	0	0.000602	0	5	16										C	37371140	G	C	37371140	1	2	7	1	0	0	0	0	0	0	0	0	10756	957	33	1		1	NUP155	5	37371140	Translation_Start_Site	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	110	37371140	143544120	169	1638										
PTGER4	5734	broad.mit.edu	37	chr5	40681862	40681862	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcgcctcagcgactttcggcGccgccggagcttccgccgca	13	18	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:40681862G>A	uc003jlz.2	+	2	1359	c.767G>A	c.(766-768)CGC>CAC	p.R256H		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	256	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						GACTTTCGGCGCCGCCGGAGC	0.716													0	0	0	0.001984	0	6	26										A	40681862	G	A	40681862	3	1	7	1	0	0	0	0	1	0	0	0	12745	1087	38	2	769	2	PTGER4	5	40681862	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3310722	40681862	140233398	170	1639										
MIER3	166968	broad.mit.edu	37	chr5	56219227	56219227	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agggtttagctccgagtgatAaaatccagtctcaaataaat	8	7	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:56219227A>T	uc003jrd.1	-	13	1406	c.1381T>A	c.(1381-1383)TAT>AAT	p.Y461N	MIER3_uc003jqz.1_Missense_Mutation_p.Y398N|MIER3_uc003jra.1_Missense_Mutation_p.Y460N|MIER3_uc003jrb.1_Missense_Mutation_p.Y285N|MIER3_uc003jrc.1_Missense_Mutation_p.Y466N	NM_152622	NP_689835	Q7Z3K6	MIER3_HUMAN	mesoderm induction early response 1, family	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Lung NSC(810;4.65e-05)|Prostate(74;0.0253)|Breast(144;0.0503)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;1.24e-37)		TCCGAGTGATAAAATCCAGTC	0.423													0	0	0	0.010504	0	19	37										T	56219227	A	T	56219227	3	4	7	1	0	0	0	0	1	0	0	0	9582	362	13	5	275	5	MIER3	5	56219227	Missense_Mutation	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	15537365	56219227	124696033	171	1640										
COL4A3BP	10087	broad.mit.edu	37	chr5	74675245	74675245	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttttagaaatttaggatactCtcgctttgccactgccctta	6	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:74675245C>G	uc011csu.1	-	17	2223	c.1801G>C	c.(1801-1803)GAG>CAG	p.E601Q	COL4A3BP_uc003kds.2_Missense_Mutation_p.E575Q|COL4A3BP_uc003kdt.2_Missense_Mutation_p.E729Q|COL4A3BP_uc003kdu.2_Missense_Mutation_p.E601Q	NM_005713	NP_005704	Q9Y5P4	C43BP_HUMAN	alpha 3 type IV collagen binding protein isoform	601	START.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			skin(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TTAGGATACTCTCGCTTTGCC	0.373													0	0	0	0.00245	0	13	20										G	74675245	C	G	74675245	3	3	7	1	0	0	0	0	1	0	0	0	3692	922	32	1	77	1	COL4A3BP	5	74675245	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	18456018	74675245	106240015	172	1641										
MSH3	4437	broad.mit.edu	37	chr5	79950603	79950603	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcctccagctcagcccctgcGaggcaagcggttttgagccg	13	15	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:79950603G>A	uc003kgz.2	+	1	310	c.57G>A	c.(55-57)GCG>GCA	p.A19A	DHFR_uc011ctl.1_5'UTR|DHFR_uc011ctm.1_5'UTR|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Silent_p.L51L|DHFR_uc003kgy.1_5'UTR	NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	19					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CAGCCCCTGCGAGGCAAGCGG	0.667								MMR					0	0	0	0.00308	0	6	12										A	79950603	G	A	79950603	2	1	7	1	0	0	0	0	0	0	0	1	9871	1045	37	1		1	MSH3	5	79950603	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5275358	79950603	100964657	173	1642										
MSH3	4437	broad.mit.edu	37	chr5	80024675	80024675	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tattctgttttctaggttctCaaattatttctggcattgtt	6	6	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:80024675C>G	uc003kgz.2	+	10	1712	c.1459C>G	c.(1459-1461)CAA>GAA	p.Q487E		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	487					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		TCTAGGTTCTCAAATTATTTC	0.264								MMR					0	0	0	0.00499	0	15	53										G	80024675	C	G	80024675	3	3	7	1	0	0	0	0	1	0	0	0	9871	827	29	1	1497	1	MSH3	5	80024675	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	74072	80024675	100890585	174	1643										
VCAN	1462	broad.mit.edu	37	chr5	82832829	82832829	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aactctgtttttttcaggtcGaatgagtgatttgagtgtaa	10	4	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:82832829G>A	uc003kii.3	+	8	4363	c.4007G>A	c.(4006-4008)CGA>CAA	p.R1336Q	VCAN_uc003kij.3_Missense_Mutation_p.R349Q|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_5'UTR	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1336	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTTTCAGGTCGAATGAGTGAT	0.368													0	0	0	0.00308	0	8	7										A	82832829	G	A	82832829	3	1	7	1	0	0	0	0	1	0	0	0	17135	1058	37	1	4033	1	VCAN	5	82832829	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2808154	82832829	98082431	175	1644										
LNPEP	4012	broad.mit.edu	37	chr5	96349455	96349455	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatgattgggaagcactaatCcatcagttgaaaataaatcc	8	7	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:96349455C>T	uc003kmv.1	+	12	2653	c.2139C>T	c.(2137-2139)ATC>ATT	p.I713I	LNPEP_uc003kmw.1_Silent_p.I699I	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	713	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		AAGCACTAATCCATCAGTTGA	0.358													0	0	0	0.010729	0	11	65										T	96349455	C	T	96349455	2	4	7	1	0	0	0	0	0	0	0	1	8864	845	30	1		1	LNPEP	5	96349455	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	13516626	96349455	84565805	176	1645										
TMED7	51014	broad.mit.edu	37	chr5	114951919	114951919	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aacgtagttatgatccaacaCgagttgtggtggttctttta	10	6	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:114951919C>T	uc003krf.2	-	3	1043	c.662G>A	c.(661-663)CGT>CAT	p.R221H	TMED7-TICAM2_uc003krd.2_Intron|TMED7-TICAM2_uc003kre.2_Intron|TMED7_uc011cwd.1_Missense_Mutation_p.R133H	NM_181836	NP_861974	Q9Y3B3	TMED7_HUMAN	transmembrane emp24 protein transport domain	221	Cytoplasmic (Potential).				transport	endoplasmic reticulum membrane|integral to membrane					0		all_cancers(142;0.0223)|all_epithelial(76;0.000869)|Prostate(80;0.0115)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;3.34e-07)|Epithelial(69;1.08e-06)|all cancers(49;4.56e-05)		TGATCCAACACGAGTTGTGGT	0.378													0	0	0	0.001368	0	12	24										T	114951919	C	T	114951919	3	4	7	1	0	0	0	0	1	0	0	0	16006	536	19	2	16	2	TMED7	5	114951919	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	18602464	114951919	65963341	177	1646										
PCDHA1	56147	broad.mit.edu	37	chr5	140167237	140167237	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgaatgacaacgcgcctgcGttcgcgcagcccgagtacac	12	14	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:140167237G>A	uc003lhb.2	+	1	1362	c.1362G>A	c.(1360-1362)GCG>GCA	p.A454A	PCDHA1_uc003lha.2_Silent_p.A454A|PCDHA1_uc003lgz.2_Silent_p.A454A	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	454	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGCCTGCGTTCGCGCAGC	0.677													0	0	0	0.005443	0	25	62										A	140167237	G	A	140167237	2	1	7	1	0	0	0	0	0	0	0	1	11519	1132	40	2		2	PCDHA1	5	140167237	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	25215318	140167237	40748023	178	1647										
PCDHB4	56131	broad.mit.edu	37	chr5	140503600	140503600	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agccctacctgcctctccctGaggcggccccggcccaggcc	11	21	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:140503600G>A	uc003lip.1	+	1	2020	c.2020G>A	c.(2020-2022)GAG>AAG	p.E674K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	674	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCTCTCCCTGAGGCGGCCCC	0.677													0	0	0	0.011902	0	43	76										A	140503600	G	A	140503600	3	1	7	1	0	0	0	0	1	0	0	0	11544	1291	45	1	2022	1	PCDHB4	5	140503600	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	336363	140503600	40411660	179	1648										
PCDHB10	56126	broad.mit.edu	37	chr5	140574015	140574015	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgcgcaccgccaggctgctGagcgagcgcgacgcagccaa	15	15	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:140574015G>A	uc003lix.2	+	1	2064	c.1890G>A	c.(1888-1890)CTG>CTA	p.L630L		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	630	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGGCTGCTGAGCGAGCGCG	0.682													0	0	0	0.004482	0	5	24										A	140574015	G	A	140574015	2	1	7	1	0	0	0	0	0	0	0	1	11535	1277	45	1		1	PCDHB10	5	140574015	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	70415	140574015	40341245	180	1649										
PCDHGA1	56114	broad.mit.edu	37	chr5	140712087	140712087	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taccgcctgctcaaggccagCgagccgggactcttctcggt	12	15	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:140712087C>T	uc003lji.1	+	1	1836	c.1836C>T	c.(1834-1836)AGC>AGT	p.S612S	PCDHGA1_uc011dan.1_Silent_p.S612S	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	612	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAAGGCCAGCGAGCCGGGAC	0.692													0	0	0	0.004007	0	16	46										T	140712087	C	T	140712087	2	4	7	1	0	0	0	0	0	0	0	1	11550	767	27	2		2	PCDHGA1	5	140712087	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	138072	140712087	40203173	181	1650										
HTR4	3360	broad.mit.edu	37	chr5	147928298	147928298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caggacgtccagagatgtccGaacaagacaaaacacctccc	8	14	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr5:147928298G>A	uc003lpn.2	-	4	450	c.286C>T	c.(286-288)CGG>TGG	p.R96W	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_Missense_Mutation_p.R96W|HTR4_uc003lpj.1_Missense_Mutation_p.R96W|HTR4_uc003lpk.2_Missense_Mutation_p.R96W|HTR4_uc011dby.1_Missense_Mutation_p.R96W|HTR4_uc003lpl.2_Missense_Mutation_p.R96W|HTR4_uc003lpm.2_Missense_Mutation_p.R96W|HTR4_uc010jgv.2_RNA|HTR4_uc003lpo.1_Missense_Mutation_p.R96W	NM_000870	NP_000861	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform b	96	Helical; Name=3; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGAGATGTCCGAACAAGACAA	0.502													0	0	0	0.009096	0	3	13										A	147928298	G	A	147928298	3	1	7	1	0	0	0	0	1	0	0	0	7449	1057	37	1	1192	1	HTR4	5	147928298	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7216211	147928298	32986962	182	1651										
FAM50B	26240	broad.mit.edu	37	chr6	3850759	3850759	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtggagcagctcatgttcatCaaggaggacctcatcctgcc	11	12	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:3850759C>T	uc003mvu.2	+	2	826	c.714C>T	c.(712-714)ATC>ATT	p.I238I		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	238						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				TCATGTTCATCAAGGAGGACC	0.627													0	0	0	0.008871	0	18	35										T	3850759	C	T	3850759	2	4	7	1	0	0	0	0	0	0	0	1	5578	816	29	1		1	FAM50B	6	3850759	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08		3850759	167264308	183	1652										
PRPF4B	8899	broad.mit.edu	37	chr6	4049306	4049306	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcaaagagaatcccaacctCagagataactggaccgatgc	8	11	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:4049306C>G	uc003mvv.2	+	8	2083	c.1992C>G	c.(1990-1992)CTC>CTG	p.L664L	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	664						catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ATCCCAACCTCAGAGATAACT	0.408													0	0	0	0.006214	0	10	39										G	4049306	C	G	4049306	2	3	7	1	0	0	0	0	0	0	0	1	12573	813	29	1		1	PRPF4B	6	4049306	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	198547	4049306	167065761	184	1653										
DSP	1832	broad.mit.edu	37	chr6	7581110	7581110	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcacgcggttccagaactctCtgaaagagctgcagctgcag	11	12	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:7581110C>G	uc003mxp.1	+	23	4966	c.4687C>G	c.(4687-4689)CTG>GTG	p.L1563V	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1563	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCAGAACTCTCTGAAAGAGCT	0.542													0	0	0	0.010818	0	32	51										G	7581110	C	G	7581110	3	3	7	1	0	0	0	0	1	0	0	0	4781	912	32	1	4777	1	DSP	6	7581110	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3531804	7581110	163533957	185	1654										
HFE	3077	broad.mit.edu	37	chr6	26092939	26092939	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctttggtgaaggtgacacatCatgtgacctcttcagtgacc	10	10	3	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:26092939C>T	uc003nfx.1	+	4	803	c.643C>T	c.(643-645)CAT>TAT	p.H215Y	HFE_uc003nfy.1_Missense_Mutation_p.H192Y|HFE_uc010jqe.1_Intron|HFE_uc003nfz.1_Missense_Mutation_p.H127Y|HFE_uc003ngd.1_Intron|HFE_uc003nga.1_Intron|HFE_uc003ngb.1_Intron|HFE_uc003ngc.1_Missense_Mutation_p.H123Y|HFE_uc003nge.1_Missense_Mutation_p.H35Y|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	215	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						GGTGACACATCATGTGACCTC	0.512									Hemochromatosis				0	0	0	0.007413	0	16	99										T	26092939	C	T	26092939	3	4	7	1	0	0	0	0	1	0	0	0	7081	826	29	1	657	1	HFE	6	26092939	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	18511829	26092939	145022128	186	1655										
HIST1H2BH	8345	broad.mit.edu	37	chr6	26252142	26252142	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctcattacaacaagcgttcGaccatcacctccagggagat	8	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:26252142G>C	uc003nhh.2	+	1	264	c.264G>C	c.(262-264)TCG>TCC	p.S88S	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	88					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						ACAAGCGTTCGACCATCACCT	0.597													0	0	0	0.001984	0	6	97										C	26252142	G	C	26252142	2	2	7	1	0	0	0	0	0	0	0	1	7147	1045	37	1		1	HIST1H2BH	6	26252142	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	159203	26252142	144862925	187	1656										
HIST1H4I	8294	broad.mit.edu	37	chr6	27107244	27107244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcatttctggcctcatctatGaggagacccgcggagtgttg	13	10	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:27107244G>C	uc003niy.1	+	1	157	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	53					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CCTCATCTATGAGGAGACCCG	0.632			T	BCL6	NHL								0	0	0	0.001984	0	7	65										C	27107244	G	C	27107244	3	2	7	1	0	0	0	0	1	0	0	0	7173	1291	45	1	159	1	HIST1H4I	6	27107244	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	855102	27107244	144007823	188	1657										
HLA-E	3133	broad.mit.edu	37	chr6	30457338	30457338	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggaaccctccttttactcctCtcggaggccctggcccttac	8	17	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:30457338C>G	uc003nqg.2	+	1	68	c.30C>G	c.(28-30)CTC>CTG	p.L10L	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Missense_Mutation_p.S8C	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	10				L -> S (in Ref. 1; AAA52655).	antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						TTTTACTCCTCTCGGAGGCCC	0.537													0	0	0	0.004289	0	35	77										G	30457338	C	G	30457338	2	3	7	1	0	0	0	0	0	0	0	1	7210	900	32	1		1	HLA-E	6	30457338	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3350094	30457338	140657729	189	1658										
BAT1	7919	broad.mit.edu	37	chr6	31498646	31498646	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaggatcttggcatcattctCatcggacacaaatgtgatag	10	8	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:31498646C>T	uc003ntt.2	-	10	1811	c.1180G>A	c.(1180-1182)GAG>AAG	p.E394K	BAT1_uc003ntq.2_Missense_Mutation_p.E127K|BAT1_uc003ntr.2_Missense_Mutation_p.E201K|BAT1_uc003nts.2_Missense_Mutation_p.M401I|BAT1_uc011dnn.1_Missense_Mutation_p.E316K|BAT1_uc003ntu.2_Missense_Mutation_p.E394K|BAT1_uc003ntv.2_Missense_Mutation_p.E394K	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	394	Helicase C-terminal.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						GCATCATTCTCATCGGACACA	0.512													0	0	0	0.001368	0	11	48										T	31498646	C	T	31498646	3	4	7	1	0	0	0	0	1	0	0	0	1318	835	29	1	114	1	BAT1	6	31498646	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1041308	31498646	139616421	190	1659										
TNXB	7148	broad.mit.edu	37	chr6	32016366	32016366	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggcccactgagtccgaggtCacggccgccaccgccagctc	12	18	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:32016366C>T	uc003nzl.2	-	29	10015	c.9813G>A	c.(9811-9813)GTG>GTA	p.V3271V	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3318	Fibronectin type-III 25.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGTCCGAGGTCACGGCCGCCA	0.701													0	0	0	0.009096	0	4	22										T	32016366	C	T	32016366	2	4	7	1	0	0	0	0	0	0	0	1	16343	813	29	1		1	TNXB	6	32016366	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	517720	32016366	139098701	191	1660										
HSD17B8	7923	broad.mit.edu	37	chr6	33173008	33173008	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctcccataggcctgcttttCtcgcccaccatctgtcgttg	7	17	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:33173008C>G	uc003odi.1	+	3	308	c.281C>G	c.(280-282)TCT>TGT	p.S94C	uc003odj.1_5'Flank|MIR219-1_hsa-mir-219-1|MI0000296_5'Flank	NM_014234	NP_055049	Q92506	DHB8_HUMAN	estradiol 17 beta-dehydrogenase 8	94					estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(1)|central_nervous_system(1)	2					NADH(DB00157)	GCCTGCTTTTCTCGCCCACCA	0.547													0	0	0	0.000602	0	5	44										G	33173008	C	G	33173008	3	3	7	1	0	0	0	0	1	0	0	0	7389	913	32	1	291	1	HSD17B8	6	33173008	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1156642	33173008	137942059	192	1661										
HSD17B8	7923	broad.mit.edu	37	chr6	33173950	33173950	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgggacacttgggggaccctGagggtgagcactgaatgtag	17	7	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:33173950G>A	uc003odi.1	+	7	718	c.691G>A	c.(691-693)GAG>AAG	p.E231K	uc003odj.1_5'Flank|MIR219-1_hsa-mir-219-1|MI0000296_5'Flank|RING1_uc011dqw.1_5'Flank|RING1_uc011dqx.1_5'Flank|RING1_uc003odk.2_5'Flank	NM_014234	NP_055049	Q92506	DHB8_HUMAN	estradiol 17 beta-dehydrogenase 8	231					estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(1)|central_nervous_system(1)	2					NADH(DB00157)	GGGGGACCCTGAGGGTGAGCA	0.488													0	0	0	0.001984	0	6	39										A	33173950	G	A	33173950	3	1	7	1	0	0	0	0	1	0	0	0	7389	1291	45	1	717	1	HSD17B8	6	33173950	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	942	33173950	137941117	193	1662										
RNF8	9025	broad.mit.edu	37	chr6	37328350	37328350	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tggacaattatggacaacaaGgtacaggaattcacagaagc	10	7	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:37328350G>T	uc003onq.3	+	2	433	c.240G>T	c.(238-240)AAG>AAT	p.K80N	RNF8_uc003onr.3_Missense_Mutation_p.K80N|RNF8_uc011dtx.1_5'UTR	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	80	FHA.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						TGGACAACAAGGTACAGGAAT	0.323													1	0	2.68362e-12	0.001368	2.85756e-12	10	28										T	37328350	G	T	37328350	3	4	7	1	0	0	0	0	1	0	0	0	13500	1014	35	4	246	4	RNF8	6	37328350	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4154400	37328350	133786717	194	1663										
TSPO2	222642	broad.mit.edu	37	chr6	41011326	41011326	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tacctggtgtggaaggacctGggagggggcttggggtggcc	21	7	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:41011326G>C	uc003opj.2	+	3	505	c.204G>C	c.(202-204)CTG>CTC	p.L68L	UNC5CL_uc010jxe.1_Intron|TSPO2_uc003opk.2_Intron|TSPO2_uc011dub.1_Silent_p.L68L	NM_001010873	NP_001010873	Q5TGU0	TSPO2_HUMAN	benzodiazapine receptor (peripheral)-like 1	68					transport	endoplasmic reticulum membrane|integral to membrane	cholesterol binding|receptor activity				0						GGAAGGACCTGGGAGGGGGCT	0.582													0	0	0	0.001368	0	11	86										C	41011326	G	C	41011326	2	2	7	1	0	0	0	0	0	0	0	1	16653	1335	47	4		4	TSPO2	6	41011326	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3682976	41011326	130103741	195	1664										
FRS3	10817	broad.mit.edu	37	chr6	41739006	41739006	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgggctgggctggacactcaGaaggggcctcattgttatta	14	8	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:41739006G>C	uc003orc.1	-	7	1074	c.830C>G	c.(829-831)TCT>TGT	p.S277C		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	277					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGACACTCAGAAGGGGCCTC	0.647													0	0	0	0.001984	0	5	45										C	41739006	G	C	41739006	3	2	7	1	0	0	0	0	1	0	0	0	6062	942	33	1	652	1	FRS3	6	41739006	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	727680	41739006	129376061	196	1665										
CUL7	9820	broad.mit.edu	37	chr6	43008354	43008354	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtggaactggcgctgcagctCcttagaggtgctcaggctct	14	11	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:43008354C>G	uc003otq.2	-	21	4240	c.3937G>C	c.(3937-3939)GAG>CAG	p.E1313Q	CUL7_uc010jyg.2_Missense_Mutation_p.E592Q|CUL7_uc011dvb.1_Missense_Mutation_p.E1397Q|CUL7_uc010jyh.2_Missense_Mutation_p.E306Q|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1313					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CGCTGCAGCTCCTTAGAGGTG	0.602													0	0	0	0.00632	0	27	129										G	43008354	C	G	43008354	3	3	7	1	0	0	0	0	1	0	0	0	4060	864	30	1	1183	1	CUL7	6	43008354	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1269348	43008354	128106713	197	1666										
MEP1A	4224	broad.mit.edu	37	chr6	46801038	46801038	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggacaagcttcagagccctCgattctacaattcggaggga	12	10	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:46801038C>T	uc010jzh.1	+	11	1414	c.1372C>T	c.(1372-1374)CGA>TGA	p.R458*	MEP1A_uc011dwg.1_Nonsense_Mutation_p.R180*|MEP1A_uc011dwh.1_Nonsense_Mutation_p.R486*|MEP1A_uc011dwi.1_Nonsense_Mutation_p.R358*	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	458	MATH.|Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			TCAGAGCCCTCGATTCTACAA	0.498													0	0	0	0.00278	0	23	46										T	46801038	C	T	46801038	4	4	7	1	0	0	0	0	0	1	0	0	9475	876	31	1	1414	1	MEP1A	6	46801038	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3792684	46801038	124314029	198	1667										
CD2AP	23607	broad.mit.edu	37	chr6	47576971	47576971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agatgatgtgaaaaaaaattCcctggatgaacttagagccc	9	7	0	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:47576971C>G	uc003oyw.2	+	16	2201	c.1745C>G	c.(1744-1746)TCC>TGC	p.S582C		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	582	Potential.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AAAAAAAATTCCCTGGATGAA	0.393													0	0	0	0.00308	0	8	61										G	47576971	C	G	47576971	3	3	7	1	0	0	0	0	1	0	0	0	2994	855	30	1	1807	1	CD2AP	6	47576971	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	775933	47576971	123538096	199	1668										
PKHD1	5314	broad.mit.edu	37	chr6	51524156	51524157	+	Missense_Mutation	DNP	TC	TC	CA													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctgatttggttttggccaaTctgtaagaagttagttagtc							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:51524156_51524157TC>CA	uc003pah.1	-	61	11043_11044	c.10767_10768GA>TG	c.(10765-10770)CAGATT>CATGTT	p.3589_3590QI>HV		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3589_3590	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTTGGCCAATCTGTAAGAAGT	0.436													0	0	0	0.004672	0	4	41										CA	51524157	TC	CA	51524156	3	2	7	1	0	0	0	0	1	0	0	0	11971	1435	50	5	1484	5	PKHD1	6	51524156	Missense_Mutation	DNP	TC	TCGA-BT-A20J-01A-11D-A14W-08	3947185	51524156	119590911	200	1669										
PAQR8	85315	broad.mit.edu	37	chr6	52268302	52268302	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgcgattctgggcctttgcCgaggctgaggccttgccatg	14	11	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:52268302C>T	uc003pao.3	+	2	465	c.291C>T	c.(289-291)GCC>GCT	p.A97A		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	97	Extracellular (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					GGGCCTTTGCCGAGGCTGAGG	0.577													0	0	0	0.001368	0	13	84										T	52268302	C	T	52268302	2	4	7	1	0	0	0	0	0	0	0	1	11441	639	23	2		2	PAQR8	6	52268302	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	744146	52268302	118846765	201	1670										
GSTA5	221357	broad.mit.edu	37	chr6	52701092	52701092	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttgctggcaatgtagttaaGaatggctctggtctgcacca	11	8	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:52701092G>T	uc003pba.1	-	4	284	c.214C>A	c.(214-216)CTT>ATT	p.L72I		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	72	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	ATGTAGTTAAGAATGGCTCTG	0.423													1	0	5.13769e-22	0.00361	5.49613e-22	51	174										T	52701092	G	T	52701092	3	4	7	1	0	0	0	0	1	0	0	0	6834	942	33	3	470	3	GSTA5	6	52701092	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	432790	52701092	118413975	202	1671										
GSTA4	2941	broad.mit.edu	37	chr6	52850346	52850346	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caacttcatcccgtcaatttCaaccatgggcacttgttgga	7	12	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:52850346C>T	uc003pbc.2	-	3	239	c.175G>A	c.(175-177)GAA>AAA	p.E59K	GSTA4_uc003pbd.2_5'UTR|GSTA4_uc003pbe.2_Intron|GSTA4_uc003pbf.2_Missense_Mutation_p.E59K	NM_001512	NP_001503	O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	59	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)	CCGTCAATTTCAACCATGGGC	0.468													0	0	0	0.001855	0	13	62										T	52850346	C	T	52850346	3	4	7	1	0	0	0	0	1	0	0	0	6833	835	29	1	509	1	GSTA4	6	52850346	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	149254	52850346	118264721	203	1672										
SMAP1	60682	broad.mit.edu	37	chr6	71566608	71566608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaccctgtctacagtaacatCtggggatctagatttattca	7	9	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:71566608C>T	uc003pfr.2	+	9	1084	c.836C>T	c.(835-837)TCT>TTT	p.S279F	SMAP1_uc003pfs.2_Missense_Mutation_p.S252F|SMAP1_uc010kao.2_Missense_Mutation_p.S252F|SMAP1_uc010kap.2_Missense_Mutation_p.S269F	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	279					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						ACAGTAACATCTGGGGATCTA	0.428													0	0	0	0.001984	0	7	82										T	71566608	C	T	71566608	3	4	7	1	0	0	0	0	1	0	0	0	14766	913	32	1	870	1	SMAP1	6	71566608	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	18716262	71566608	99548459	204	1673										
FAM46A	55603	broad.mit.edu	37	chr6	82459984	82459984	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tattgtggggtgaaatgtctCagtcattgggttctctgaac	12	6	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:82459984C>T	uc003pjg.2	-	3	1075	c.757G>A	c.(757-759)GAG>AAG	p.E253K	FAM46A_uc003pjf.2_Missense_Mutation_p.E272K	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	253											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		TGAAATGTCTCAGTCATTGGG	0.438													0	0	0	0.008871	0	16	70										T	82459984	C	T	82459984	3	4	7	1	0	0	0	0	1	0	0	0	5565	835	29	1	575	1	FAM46A	6	82459984	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10893376	82459984	88655083	205	1674										
NT5E	4907	broad.mit.edu	37	chr6	86181054	86181054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aattattgcactgggacattCgggttttgaaatggataaac	10	5	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:86181054C>T	uc003pko.3	+	3	1218	c.662C>T	c.(661-663)TCG>TTG	p.S221L	NT5E_uc003pkn.2_Missense_Mutation_p.S221L|NT5E_uc010kbr.2_Missense_Mutation_p.S221L	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	221					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	CTGGGACATTCGGGTTTTGAA	0.393													0	0	0	0.004482	0	8	37										T	86181054	C	T	86181054	3	4	7	1	0	0	0	0	1	0	0	0	10693	893	31	1	672	1	NT5E	6	86181054	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3721070	86181054	84934013	206	1675										
ORC3L	23595	broad.mit.edu	37	chr6	88362934	88362934	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcagcacagctaagagaataGaggagttcctggcccagttt	12	9	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:88362934G>C	uc003pmh.2	+	14	1527	c.1483G>C	c.(1483-1485)GAG>CAG	p.E495Q	ORC3L_uc011dzl.1_Missense_Mutation_p.E495Q|ORC3L_uc011dzm.1_Missense_Mutation_p.E495Q|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Missense_Mutation_p.E495Q|ORC3L_uc003pmi.2_Missense_Mutation_p.E457Q|ORC3L_uc011dzo.1_Missense_Mutation_p.E352Q|ORC3L_uc011dzp.1_Missense_Mutation_p.E352Q	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	495					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		TAAGAGAATAGAGGAGTTCCT	0.403													0	0	0	0.001984	0	6	55										C	88362934	G	C	88362934	3	2	7	1	0	0	0	0	1	0	0	0	11263	943	33	1	1537	1	ORC3L	6	88362934	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2181880	88362934	82752133	207	1676										
BACH2	60468	broad.mit.edu	37	chr6	90718326	90718326	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accaaattactgtacctcctCaggcaagctgaccaccaaat	5	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:90718326C>T	uc011eab.1	-	6	1047	c.238G>A	c.(238-240)GAG>AAG	p.E80K	BACH2_uc003pnw.2_Missense_Mutation_p.E80K|BACH2_uc010kch.2_Missense_Mutation_p.E80K	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	80	BTB.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TGTACCTCCTCAGGCAAGCTG	0.473													0	0	0	0.001984	0	6	52										T	90718326	C	T	90718326	3	4	7	1	0	0	0	0	1	0	0	0	1284	835	29	1	2303	1	BACH2	6	90718326	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2355392	90718326	80396741	208	1677										
RTN4IP1	84816	broad.mit.edu	37	chr6	107035677	107035677	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtggctcctgaccatttcttGagaaaatctggagcccatgt	10	10	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:107035677G>C	uc003prj.2	-	7	1344	c.867C>G	c.(865-867)CTC>CTG	p.L289L	RTN4IP1_uc010kdd.2_Intron|RTN4IP1_uc003prk.2_Silent_p.L189L	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	289						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		ACCATTTCTTGAGAAAATCTG	0.458													0	0	0	0.001984	0	7	194										C	107035677	G	C	107035677	2	2	7	1	0	0	0	0	0	0	0	1	13729	1277	45	1		1	RTN4IP1	6	107035677	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	16317351	107035677	64079390	209	1678										
MAP3K5	4217	broad.mit.edu	37	chr6	136977457	136977457	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtactcactggaaacctaacCacagtaacatctgtctttgt	6	11	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:136977457C>G	uc003qhc.2	-	10	2029	c.1668G>C	c.(1666-1668)GTG>GTC	p.V556V	MAP3K5_uc011edj.1_5'UTR|MAP3K5_uc011edk.1_Silent_p.V401V|MAP3K5_uc010kgw.1_Silent_p.V556V	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	556					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GAAACCTAACCACAGTAACAT	0.408													0	0	0	0.006214	0	9	78										G	136977457	C	G	136977457	2	3	7	1	0	0	0	0	0	0	0	1	9253	581	21	4		4	MAP3K5	6	136977457	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	29941780	136977457	34137610	210	1679										
UTRN	7402	broad.mit.edu	37	chr6	144803392	144803392	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaggtgagagtgaagattctCaaggacaacatcaagttatt	11	5	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:144803392C>T	uc003qkt.2	+	26	3647	c.3555C>T	c.(3553-3555)CTC>CTT	p.L1185L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1185	Spectrin 8.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TGAAGATTCTCAAGGACAACA	0.458													0	0	0	0.006214	0	9	37										T	144803392	C	T	144803392	2	4	7	1	0	0	0	0	0	0	0	1	17100	813	29	1		1	UTRN	6	144803392	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7825935	144803392	26311675	211	1680										
RMND1	55005	broad.mit.edu	37	chr6	151742433	151742433	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acttcttcatgagatagtttCactttcttcccagcttttaa	4	10	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:151742433C>T	uc003qoi.2	-	9	1206	c.1026G>A	c.(1024-1026)GTG>GTA	p.V342V	RMND1_uc011eeq.1_Silent_p.V131V	NM_017909	NP_060379	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog	342											0		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		GAGATAGTTTCACTTTCTTCC	0.328													0	0	0	0.004482	0	6	35										T	151742433	C	T	151742433	2	4	7	1	0	0	0	0	0	0	0	1	13396	813	29	1		1	RMND1	6	151742433	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6939041	151742433	19372634	212	1681										
CNKSR3	154043	broad.mit.edu	37	chr6	154771348	154771348	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgctcgccgttgatcttctCtcgttcaaacttgtggacat	8	12	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:154771348C>G	uc003qpy.2	-	2	602	c.97G>C	c.(97-99)GAG>CAG	p.E33Q		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	33	SAM.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		TTGATCTTCTCTCGTTCAAAC	0.517													0	0	0	0.001368	0	11	37										G	154771348	C	G	154771348	3	3	7	1	0	0	0	0	1	0	0	0	3608	922	32	1	1618	1	CNKSR3	6	154771348	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3028915	154771348	16343719	213	1682										
QKI	9444	broad.mit.edu	37	chr6	163899843	163899843	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgggagaatccttggacctaGaggacttacagccaaacaac	10	10	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:163899843G>C	uc003qui.2	+	3	868	c.317G>C	c.(316-318)AGA>ACA	p.R106T	QKI_uc003que.2_Missense_Mutation_p.R106T|QKI_uc003quf.2_Missense_Mutation_p.R106T|QKI_uc003qug.2_Missense_Mutation_p.R106T|QKI_uc003quh.2_Missense_Mutation_p.R106T|QKI_uc003quj.2_Missense_Mutation_p.R106T	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	106	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		CTTGGACCTAGAGGACTTACA	0.358													0	0	0	0.003163	0	14	68										C	163899843	G	C	163899843	3	2	7	1	0	0	0	0	1	0	0	0	12873	942	33	1	327	1	QKI	6	163899843	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	9128495	163899843	7215224	214	1683										
FRMD1	79981	broad.mit.edu	37	chr6	168464360	168464360	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcacagcatggcctccttgGggctcaggccctggcgctca	13	15	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:168464360G>C	uc003qwo.3	-	6	790	c.725C>G	c.(724-726)CCC>CGC	p.P242R	FRMD1_uc003qwm.3_Missense_Mutation_p.P13R|FRMD1_uc011egs.1_Missense_Mutation_p.P13R|FRMD1_uc011egt.1_Missense_Mutation_p.P154R|FRMD1_uc003qwn.3_Missense_Mutation_p.P174R	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	242	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGCCTCCTTGGGGCTCAGGCC	0.652													0	0	0	0.006214	0	8	24										C	168464360	G	C	168464360	3	2	7	1	0	0	0	0	1	0	0	0	6049	1232	43	4	948	4	FRMD1	6	168464360	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4564517	168464360	2650707	215	1684										
SMOC2	64094	broad.mit.edu	37	chr6	169051384	169051384	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtccgggtgccaaaaagcatGagtttctgaccagcgttctg	12	10	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr6:169051384G>A	uc003qws.1	+	10	951	c.931G>A	c.(931-933)GAG>AAG	p.E311K	SMOC2_uc003qwr.1_Missense_Mutation_p.E322K|SMOC2_uc011egu.1_5'UTR	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	311					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CAAAAAGCATGAGTTTCTGAC	0.512													0	0	0	0.001984	0	7	11										A	169051384	G	A	169051384	3	1	7	1	0	0	0	0	1	0	0	0	14802	1291	45	1	1002	1	SMOC2	6	169051384	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	587024	169051384	2063683	216	1685										
MIOS	54468	broad.mit.edu	37	chr7	7628157	7628157	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caaagttgcagtacgtgacaGagtggcatttgcttgtaaat	11	6	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:7628157G>C	uc003srf.2	+	8	2155	c.1847G>C	c.(1846-1848)AGA>ACA	p.R616T	MIOS_uc003srg.2_Missense_Mutation_p.R151T|MIOS_uc010ktq.2_Missense_Mutation_p.E14Q	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	616											0						GTACGTGACAGAGTGGCATTT	0.343													0	0	0	0.006122	0	13	37										C	7628157	G	C	7628157	3	2	7	1	0	0	0	0	1	0	0	0	9589	942	33	1	1865	1	MIOS	7	7628157	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		7628157	151510506	217	1686										
CACNA2D1	781	broad.mit.edu	37	chr7	82072745	82072745	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caaagattggaaaagtgtcaGagtcaaggccagcaggcagc	13	8	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:82072745G>C	uc003uhr.1	-	1	287	c.31C>G	c.(31-33)CTG>GTG	p.L11V		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	11						voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AAAAGTGTCAGAGTCAAGGCC	0.537													0	0	0	0.009096	0	4	26										C	82072745	G	C	82072745	3	2	7	1	0	0	0	0	1	0	0	0	2548	933	33	1	3400	1	CACNA2D1	7	82072745	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	74444588	82072745	77065918	218	1687										
TAF6	6878	broad.mit.edu	37	chr7	99707583	99707583	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcagtcaccagcaggaggctCtgcacatggtctgctccaat	10	13	4	0	rs145206628		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:99707583C>G	uc003uti.2	-	12	1353	c.1272G>C	c.(1270-1272)CAG>CAC	p.Q424H	AP4M1_uc003utd.2_Intron|TAF6_uc003utg.2_Missense_Mutation_p.Q346H|TAF6_uc003uth.2_Missense_Mutation_p.Q481H|TAF6_uc003utk.2_Missense_Mutation_p.Q424H|TAF6_uc011kji.1_Missense_Mutation_p.Q461H|TAF6_uc003utj.2_Missense_Mutation_p.Q414H|TAF6_uc003utl.2_Missense_Mutation_p.Q424H|TAF6_uc003utm.2_Missense_Mutation_p.Q424H	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	424					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAGGAGGCTCTGCACATGGT	0.572													0	0	0	0.008291	0	10	72										G	99707583	C	G	99707583	3	3	7	1	0	0	0	0	1	0	0	0	15527	912	32	1	777	1	TAF6	7	99707583	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	17634838	99707583	59431080	219	1688										
PIK3CG	5294	broad.mit.edu	37	chr7	106509785	106509785	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaagcatatcctaagctattTagttcagtgaaatggggaca	9	6	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:106509785T>C	uc003vdv.3	+	2	1864	c.1779T>C	c.(1777-1779)TTT>TTC	p.F593F	PIK3CG_uc003vdu.2_Silent_p.F593F|PIK3CG_uc003vdw.2_Silent_p.F593F	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	593					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CTAAGCTATTTAGTTCAGTGA	0.433													0	0	0	0.009535	0	27	68										C	106509785	T	C	106509785	2	2	7	1	0	0	0	0	0	0	0	1	11916	1751	61	5		5	PIK3CG	7	106509785	Silent	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	6802202	106509785	52628878	220	1689										
FOXP2	93986	broad.mit.edu	37	chr7	114304340	114304340	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcactaggctgccttggcaGagagcagtttacctttgcta	10	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:114304340G>T	uc003vhb.2	+	16	2226	c.1852G>T	c.(1852-1854)GAG>TAG	p.E618*	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Nonsense_Mutation_p.E643*|FOXP2_uc003vha.2_Nonsense_Mutation_p.E526*|FOXP2_uc011kmu.1_Nonsense_Mutation_p.E635*|FOXP2_uc011kmv.1_Nonsense_Mutation_p.E617*|FOXP2_uc010ljz.1_Nonsense_Mutation_p.E433*	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	618					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TGCCTTGGCAGAGAGCAGTTT	0.388													1	0	0.000274275	0.004482	0.000281203	7	16										T	114304340	G	T	114304340	4	4	7	1	0	0	0	0	0	1	0	0	6027	943	33	3	2077	3	FOXP2	7	114304340	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7794555	114304340	44834323	221	1690										
MET	4233	broad.mit.edu	37	chr7	116409824	116409824	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccaatgacctgctgaaattGaacagcgagctaaatataga	8	9	0	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:116409824G>C	uc003vij.2	+	12	2896	c.2709G>C	c.(2707-2709)TTG>TTC	p.L903F	MET_uc010lkh.2_Missense_Mutation_p.L921F|MET_uc011knj.1_Missense_Mutation_p.L473F	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	903	Extracellular (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGCTGAAATTGAACAGCGAGC	0.373			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.000602	0	5	26										C	116409824	G	C	116409824	3	2	7	1	0	0	0	0	1	0	0	0	9485	1281	45	1	2805	1	MET	7	116409824	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2105484	116409824	42728839	222	1691										
MET	4233	broad.mit.edu	37	chr7	116436028	116436028	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcccggatatcagcgatcttCtctactttcattggggagca	9	11	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:116436028C>T	uc003vij.2	+	21	4210	c.4023C>T	c.(4021-4023)TTC>TTT	p.F1341F	MET_uc010lkh.2_Silent_p.F1359F|MET_uc011knj.1_Silent_p.F911F	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	1341	Protein kinase.|Interaction with MUC20.|Interaction with RANBP9.|Cytoplasmic (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CAGCGATCTTCTCTACTTTCA	0.443			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.00499	0	18	75										T	116436028	C	T	116436028	2	4	7	1	0	0	0	0	0	0	0	1	9485	912	32	1		1	MET	7	116436028	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	26204	116436028	42702635	223	1692										
TTC26	79989	broad.mit.edu	37	chr7	138863036	138863036	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatgatgttttgatttacctCaactcatttaaggtcagtat	7	6	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:138863036C>G	uc003vus.2	+	13	1260	c.1146C>G	c.(1144-1146)CTC>CTG	p.L382L	TTC26_uc011kqn.1_Silent_p.L382L|TTC26_uc011kqo.1_Silent_p.L351L|TTC26_uc011kqp.1_Silent_p.L277L|TTC26_uc003vut.2_Silent_p.L242L|TTC26_uc011kqq.1_Silent_p.L251L	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	382							binding			ovary(1)	1						TGATTTACCTCAACTCATTTA	0.373													0	0	0	0.006214	0	10	55										G	138863036	C	G	138863036	2	3	7	1	0	0	0	0	0	0	0	1	16691	813	29	1		1	TTC26	7	138863036	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	22427008	138863036	20275627	224	1693										
MLL3	58508	broad.mit.edu	37	chr7	151927069	151927069	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagaacaggcaagtaatcttCcttctgctccttggccaaaa	8	11	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:151927069C>T	uc003wla.2	-	18	3134	c.2915G>A	c.(2914-2916)GGA>GAA	p.G972E	MLL3_uc003wkz.2_Missense_Mutation_p.G33E	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	972	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AAGTAATCTTCCTTCTGCTCC	0.353			N		medulloblastoma								0	0	0	0.008871	0	10	165										T	151927069	C	T	151927069	3	4	7	1	0	0	0	0	1	0	0	0	9622	855	30	1	11988	1	MLL3	7	151927069	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	13064033	151927069	7211594	225	1694										
WDR60	55112	broad.mit.edu	37	chr7	158704352	158704353	+	Frame_Shift_Ins	INS	-	-	A													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtatatcagaaactttgggINSaaaaaaaataccaagcaggt							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr7:158704352_158704353insA	uc003woe.3	+	12	1730_1731	c.1572_1573insA	c.(1570-1575)GGGAAAfs	p.G524fs	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Frame_Shift_Ins_p.G156fs	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	524_525								p.G524R(1)		ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		GAAACTTTGGGAAAAAAAATAC	0.332																		16	93	---	---								A	158704353	-	A	158704352	7	5	7	1	0	1	1	0	0	0	0	0	17308	1161	41	0	1618	0	WDR60	7	158704352	Frame_Shift_Ins	INS	-	TCGA-BT-A20J-01A-11D-A14W-08	6777283	158704352	434311	226	1695										
PSD3	23362	broad.mit.edu	37	chr8	18622977	18622977	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	actttcagcagatccttggaGaaatcaacaccctcatttac	5	12	3	2	rs139539737	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:18622977G>A	uc003wza.2	-	9	2257	c.2154C>T	c.(2152-2154)TTC>TTT	p.F718F	PSD3_uc003wyy.2_Silent_p.F184F|PSD3_uc003wyz.2_Silent_p.F19F	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	719	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GATCCTTGGAGAAATCAACAC	0.393													0	0	0	0.008871	0	17	83										A	18622977	G	A	18622977	2	1	7	1	0	0	0	0	0	0	0	1	12648	933	33	1		1	PSD3	8	18622977	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		18622977	127741045	227	1696										
EPB49	2039	broad.mit.edu	37	chr8	21926966	21926966	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggtcgcctggaatcatctctCaggcctcggcccccagaacc	10	17	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:21926966C>T	uc011kyt.1	+	6	560	c.331C>T	c.(331-333)CAG>TAG	p.Q111*	EPB49_uc010ltl.2_Nonsense_Mutation_p.Q111*|EPB49_uc011kys.1_Nonsense_Mutation_p.Q71*|EPB49_uc010ltn.2_Nonsense_Mutation_p.Q86*|EPB49_uc011kyu.1_Nonsense_Mutation_p.Q111*|EPB49_uc011kyv.1_Nonsense_Mutation_p.Q111*|EPB49_uc010ltq.2_Nonsense_Mutation_p.Q111*	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	111					actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		AATCATCTCTCAGGCCTCGGC	0.632													0	0	0	0.00245	0	14	22										T	21926966	C	T	21926966	4	4	7	1	0	0	0	0	0	1	0	0	5159	827	29	1	349	1	EPB49	8	21926966	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3303989	21926966	124437056	228	1697										
CHMP7	91782	broad.mit.edu	37	chr8	23112846	23112846	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgtcagagctcagcaccctCtgtgctaactcctgcccaga	8	16	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:23112846C>T	uc003xdc.2	+	4	1206	c.558C>T	c.(556-558)CTC>CTT	p.L186L	CHMP7_uc011kzs.1_RNA|CHMP7_uc003xdd.2_Silent_p.L76L|CHMP7_uc003xde.2_Silent_p.L44L	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	186					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TCAGCACCCTCTGTGCTAACT	0.582													0	0	0	0.006122	0	18	21										T	23112846	C	T	23112846	2	4	7	1	0	0	0	0	0	0	0	1	3361	900	32	1		1	CHMP7	8	23112846	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1185880	23112846	123251176	229	1698										
CYP7A1	1581	broad.mit.edu	37	chr8	59409297	59409297	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcattgagaaacatgcgcagGctgatcagttctgagatgct	11	8	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:59409297G>C	uc003xtm.3	-	3	837	c.774C>G	c.(772-774)AGC>AGG	p.S258R		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	258					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ACATGCGCAGGCTGATCAGTT	0.517									Neonatal_Giant_Cell_Hepatitis				0	0	0	0.001368	0	12	177										C	59409297	G	C	59409297	3	2	7	1	0	0	0	0	1	0	0	0	4196	1194	42	4	756	4	CYP7A1	8	59409297	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	36296451	59409297	86954725	230	1699										
MTFR1	9650	broad.mit.edu	37	chr8	66619459	66619459	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgctagagatccttaaagaGatgaacagtgtaaaacttcg	9	6	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:66619459G>A	uc003xvm.2	+	6	944	c.732G>A	c.(730-732)GAG>GAA	p.E244E	MTFR1_uc011lep.1_Silent_p.E244E|MTFR1_uc003xvn.2_Silent_p.E211E|MTFR1_uc003xvo.1_Silent_p.E234E	NM_014637	NP_055452	Q15390	MTFR1_HUMAN	mitochondrial fission regulator 1 isoform 1	244						mitochondrion|plasma membrane				pancreas(1)	1			Epithelial(68;0.0526)|BRCA - Breast invasive adenocarcinoma(89;0.156)|all cancers(69;0.171)|OV - Ovarian serous cystadenocarcinoma(28;0.194)			TCCTTAAAGAGATGAACAGTG	0.378													0	0	0	0.001168	0	6	83										A	66619459	G	A	66619459	2	1	7	1	0	0	0	0	0	0	0	1	9925	933	33	1		1	MTFR1	8	66619459	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7210162	66619459	79744563	231	1700										
CRISPLD1	83690	broad.mit.edu	37	chr8	75941732	75941732	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acctacattgcttcttttcaGaatggaatcttctcagaaag	6	9	4	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:75941732G>C	uc003yan.2	+	14	1806	c.1431G>C	c.(1429-1431)CAG>CAC	p.Q477H	CRISPLD1_uc011lfk.1_Missense_Mutation_p.Q289H|CRISPLD1_uc011lfl.1_Missense_Mutation_p.Q289H	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	477	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CTTCTTTTCAGAATGGAATCT	0.373													0	0	0	0.001168	0	4	30										C	75941732	G	C	75941732	3	2	7	1	0	0	0	0	1	0	0	0	3882	933	33	1	1481	1	CRISPLD1	8	75941732	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	9322273	75941732	70422290	232	1701										
PSKH2	85481	broad.mit.edu	37	chr8	87076269	87076269	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctttcatcatcaaaaggcagGaatccgctaagtaaagcata	7	9	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:87076269G>C	uc011lfy.1	-	2	777	c.777C>G	c.(775-777)TTC>TTG	p.F259L		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	259	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			CAAAAGGCAGGAATCCGCTAA	0.408													0	0	0	0.006214	0	10	58										C	87076269	G	C	87076269	3	2	7	1	0	0	0	0	1	0	0	0	12665	1165	41	1	386	1	PSKH2	8	87076269	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	11134537	87076269	59287753	233	1702										
ZFPM2	23414	broad.mit.edu	37	chr8	106814193	106814193	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcaaacatcttgcatcaattCttccactgtcttagatttaa	3	10	5	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:106814193C>G	uc003ymd.2	+	8	1906	c.1883C>G	c.(1882-1884)TCT>TGT	p.S628C	ZFPM2_uc011lhs.1_Missense_Mutation_p.S359C	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	628					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGCATCAATTCTTCCACTGTC	0.448													0	0	0	0.006122	0	18	33										G	106814193	C	G	106814193	3	3	7	1	0	0	0	0	1	0	0	0	17655	913	32	1	1913	1	ZFPM2	8	106814193	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	19737924	106814193	39549829	234	1703										
SYBU	55638	broad.mit.edu	37	chr8	110587905	110587905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taacccatctgccattgtgtCaagaggggggttgagggtta	14	7	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:110587905C>G	uc003ynj.3	-	7	1385	c.1222G>C	c.(1222-1224)GAC>CAC	p.D408H	SYBU_uc003yni.3_Missense_Mutation_p.D405H|SYBU_uc003ynk.3_Missense_Mutation_p.D289H|SYBU_uc010mco.2_Missense_Mutation_p.D407H|SYBU_uc003ynl.3_Missense_Mutation_p.D407H|SYBU_uc010mcp.2_Missense_Mutation_p.D408H|SYBU_uc010mcq.2_Missense_Mutation_p.D408H|SYBU_uc003yno.3_Missense_Mutation_p.D289H|SYBU_uc010mcr.2_Missense_Mutation_p.D408H|SYBU_uc003ynm.3_Missense_Mutation_p.D407H|SYBU_uc003ynn.3_Missense_Mutation_p.D407H|SYBU_uc010mcs.2_Missense_Mutation_p.D289H|SYBU_uc010mct.2_Missense_Mutation_p.D408H|SYBU_uc010mcu.2_Missense_Mutation_p.D407H|SYBU_uc003ynp.3_Missense_Mutation_p.D340H|SYBU_uc010mcv.2_Missense_Mutation_p.D408H|SYBU_uc003ynh.3_Missense_Mutation_p.D202H|SYBU_uc011lhw.1_Missense_Mutation_p.D278H	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	408	Sufficient for interaction with STX1A.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						GCCATTGTGTCAAGAGGGGGG	0.537													0	0	0	0.010729	0	9	77										G	110587905	C	G	110587905	3	3	7	1	0	0	0	0	1	0	0	0	15424	826	29	1	773	1	SYBU	8	110587905	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3773712	110587905	35776117	235	1704										
EXT1	2131	broad.mit.edu	37	chr8	119122991	119122991	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcgaagcaggactccatgcGgcacttcttgcctttgtaga	10	11	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:119122991G>A	uc003yok.1	-	1	1068	c.295C>T	c.(295-297)CGC>TGC	p.R99C		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	99	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			GACTCCATGCGGCACTTCTTG	0.498			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				0	0	0	0.001855	0	13	71										A	119122991	G	A	119122991	3	1	7	1	0	0	0	0	1	0	0	0	5323	1116	39	2	1989	2	EXT1	8	119122991	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8535086	119122991	27241031	236	1705										
TRIB1	10221	broad.mit.edu	37	chr8	126448548	126448548	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtgcctcattcgcagcctCttgagacgggagccctccga	12	14	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:126448548C>G	uc003yrx.2	+	3	1536	c.954C>G	c.(952-954)CTC>CTG	p.L318L	TRIB1_uc011lis.1_Silent_p.L152L|TRIB1_uc010mdn.2_Silent_p.L87L	NM_025195	NP_079471	Q96RU8	TRIB1_HUMAN	G-protein-coupled receptor induced protein	318	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			lung(1)	1	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			TTCGCAGCCTCTTGAGACGGG	0.562													0	0	0	0.001984	0	7	94										G	126448548	C	G	126448548	2	3	7	1	0	0	0	0	0	0	0	1	16479	900	32	1		1	TRIB1	8	126448548	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7325557	126448548	19915474	237	1706										
MYC	4609	broad.mit.edu	37	chr8	128750661	128750661	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccagcgaggatatctggaaGaaattcgagctgctgcccac	11	12	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:128750661G>A	uc003ysh.1	+	3	666	c.153G>A	c.(151-153)AAG>AAA	p.K51K	MYC_uc003ysi.2_Silent_p.K66K	NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	51					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		ATATCTGGAAGAAATTCGAGC	0.657		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	36										A	128750661	G	A	128750661	2	1	7	1	0	0	0	0	0	0	0	1	10016	933	33	1		1	MYC	8	128750661	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2302113	128750661	17613361	238	1707										
PTK2	5747	broad.mit.edu	37	chr8	141856744	141856744	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcaatttcctggtccacttGatcagctatctctaacatat	5	11	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:141856744G>C	uc003yvu.2	-	6	714	c.484C>G	c.(484-486)CAA>GAA	p.Q162E	PTK2_uc003yvq.2_5'Flank|PTK2_uc003yvr.2_Missense_Mutation_p.Q61E|PTK2_uc003yvs.2_Missense_Mutation_p.Q162E|PTK2_uc003yvt.2_Missense_Mutation_p.Q184E|PTK2_uc003yvv.2_Missense_Mutation_p.Q49E|PTK2_uc011ljr.1_Missense_Mutation_p.Q162E	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	162	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TGGTCCACTTGATCAGCTATC	0.299													0	0	0	0.009096	0	4	46										C	141856744	G	C	141856744	3	2	7	1	0	0	0	0	1	0	0	0	12762	1299	45	1	2782	1	PTK2	8	141856744	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	13106083	141856744	4507278	239	1708										
EPPK1	83481	broad.mit.edu	37	chr8	144943483	144943483	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcctgcccgagctgctcactCagctccctgcccaccaggcc	9	21	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr8:144943483C>G	uc003zaa.1	-	1	3952	c.3939G>C	c.(3937-3939)CTG>CTC	p.L1313L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1313	Plectin 22.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTGCTCACTCAGCTCCCTGC	0.652													0	0	0	0.003954	0	21	74										G	144943483	C	G	144943483	2	3	7	1	0	0	0	0	0	0	0	1	5190	813	29	1		1	EPPK1	8	144943483	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3086739	144943483	1420539	240	1709										
DOCK8	81704	broad.mit.edu	37	chr9	422095	422095	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaaatttgagatggaagaaaGagcagacacattggcggcaa	12	5	0	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:422095G>C	uc003zgf.2	+	33	4313	c.4201G>C	c.(4201-4203)GAG>CAG	p.E1401Q	DOCK8_uc010mgu.2_Missense_Mutation_p.E703Q|DOCK8_uc010mgv.2_Missense_Mutation_p.E1301Q|DOCK8_uc003zgk.2_Missense_Mutation_p.E859Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1401	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ATGGAAGAAAGAGCAGACACA	0.413													0	0	0	0.009096	0	3	38										C	422095	G	C	422095	3	2	7	1	0	0	0	0	1	0	0	0	4693	943	33	1	4331	1	DOCK8	9	422095	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		422095	140791336	241	1710										
RPS6	6194	broad.mit.edu	37	chr9	19376351	19376351	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agagaggaaagtctgcgtctCttcgcaatttgttcctggcg	12	9	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:19376351C>G	uc003znv.1	-	6	732	c.690G>C	c.(688-690)AAG>AAC	p.K230N	RPS6_uc003znu.1_Missense_Mutation_p.K199N	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	230					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		GTCTGCGTCTCTTCGCAATTT	0.408													0	0	0	0.004656	0	23	53										G	19376351	C	G	19376351	3	3	7	1	0	0	0	0	1	0	0	0	13649	912	32	1	63	1	RPS6	9	19376351	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	18954256	19376351	121837080	242	1711										
ELAVL2	1993	broad.mit.edu	37	chr9	23731071	23731071	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcagggtgttgatagctttCtctgcatccttggggtcaat	11	8	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:23731071C>G	uc003zpu.2	-	3	557	c.282G>C	c.(280-282)GAG>GAC	p.E94D	ELAVL2_uc003zps.2_Missense_Mutation_p.E94D|ELAVL2_uc003zpt.2_Missense_Mutation_p.E94D|ELAVL2_uc003zpv.2_Missense_Mutation_p.E94D|ELAVL2_uc003zpw.2_Missense_Mutation_p.E94D	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	94	RRM 1.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGATAGCTTTCTCTGCATCCT	0.358													0	0	0	0.001168	0	6	16										G	23731071	C	G	23731071	3	3	7	1	0	0	0	0	1	0	0	0	5050	912	32	1	817	1	ELAVL2	9	23731071	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4354720	23731071	117482360	243	1712										
TOPORS	10210	broad.mit.edu	37	chr9	32543021	32543021	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cataagaacctaagtcctcaGaatcagaggacagttcaaca	7	10	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:32543021G>A	uc003zrb.2	-	3	1669	c.1502C>T	c.(1501-1503)TCT>TTT	p.S501F	TOPORS_uc003zrc.2_Missense_Mutation_p.S434F	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	501	Interaction with p53/TP53.|Required for sumoylation and localization to discrete nuclear foci.|Interaction with SUMO1.|Interaction with TOP1.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TAAGTCCTCAGAATCAGAGGA	0.403													0	0	0	0.009535	0	32	41										A	32543021	G	A	32543021	3	1	7	1	0	0	0	0	1	0	0	0	16367	942	33	1	1639	1	TOPORS	9	32543021	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8811950	32543021	108670410	244	1713										
TOPORS	10210	broad.mit.edu	37	chr9	32544192	32544192	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atctaagtaagacacattatCaaatctatccaagcatatag	4	8	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:32544192C>G	uc003zrb.2	-	3	498	c.331G>C	c.(331-333)GAT>CAT	p.D111H	TOPORS_uc003zrc.2_Missense_Mutation_p.D44H	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	111	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.|RING-type.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		GACACATTATCAAATCTATCC	0.413													0	0	0	0.003163	0	14	61										G	32544192	C	G	32544192	3	3	7	1	0	0	0	0	1	0	0	0	16367	826	29	1	2810	1	TOPORS	9	32544192	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1171	32544192	108669239	245	1714										
GRHPR	9380	broad.mit.edu	37	chr9	37429803	37429803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagggcgccagcccaggcctGaggaagcagcagaattccag	14	13	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:37429803G>C	uc003zzu.1	+	6	609	c.568G>C	c.(568-570)GAG>CAG	p.E190Q	GRHPR_uc010mlv.1_Missense_Mutation_p.E110Q|GRHPR_uc003zzt.1_Missense_Mutation_p.E110Q|GRHPR_uc003zzv.1_Missense_Mutation_p.E47Q|GRHPR_uc003zzw.1_Missense_Mutation_p.E47Q	NM_012203	NP_036335	Q9UBQ7	GRHPR_HUMAN	glyoxylate reductase/hydroxypyruvate reductase	190					cellular nitrogen compound metabolic process|excretion|glyoxylate metabolic process	peroxisomal matrix	glycerate dehydrogenase activity|glyoxylate reductase (NADP) activity|hydroxypyruvate reductase activity|NAD binding|protein binding				0				GBM - Glioblastoma multiforme(29;0.00687)		GCCCAGGCCTGAGGAAGCAGC	0.537													0	0	0	0.001984	0	5	22										C	37429803	G	C	37429803	3	2	7	1	0	0	0	0	1	0	0	0	6766	1291	45	1	590	1	GRHPR	9	37429803	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4885611	37429803	103783628	246	1715										
TMEM2	23670	broad.mit.edu	37	chr9	74319522	74319522	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaaacatacttgttgaagttGacgaggtatagaaatgtagt	11	3	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:74319522G>C	uc011lsa.1	-	18	3723	c.3183C>G	c.(3181-3183)GTC>GTG	p.V1061V	TMEM2_uc011lrz.1_Silent_p.V54V|TMEM2_uc010mos.2_Silent_p.V998V|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1061						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGTTGAAGTTGACGAGGTATA	0.433													0	0	0	0.008361	0	27	38										C	74319522	G	C	74319522	2	2	7	1	0	0	0	0	0	0	0	1	16118	1277	45	1		1	TMEM2	9	74319522	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	36889719	74319522	66893909	247	1716										
ROR2	4920	broad.mit.edu	37	chr9	94486310	94486310	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccggcaccggctggtagccGttgacggggacgtagagctg	18	11	0	2	rs146432734		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:94486310G>A	uc004arj.1	-	9	2665	c.2466C>T	c.(2464-2466)AAC>AAT	p.N822N	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	822	Cytoplasmic (Potential).|Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCTGGTAGCCGTTGACGGGGA	0.662													0	0	0	0.00361	0	38	32										A	94486310	G	A	94486310	2	1	7	1	0	0	0	0	0	0	0	1	13527	1136	40	2		2	ROR2	9	94486310	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	20166788	94486310	46727121	248	1717										
SPTLC1	10558	broad.mit.edu	37	chr9	94809522	94809522	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acaggggaggtaacgaagctGaaaagcagtatccctggccg	14	9	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:94809522G>T	uc004arl.1	-	11	1051	c.1013C>A	c.(1012-1014)TCA>TAA	p.S338*	SPTLC1_uc011ltv.1_Nonsense_Mutation_p.S338*	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	338	Cytoplasmic (Potential).					integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TAACGAAGCTGAAAAGCAGTA	0.438													1	0	4.68919e-08	0.008291	4.93976e-08	9	48										T	94809522	G	T	94809522	4	4	7	1	0	0	0	0	0	1	0	0	15122	1294	45	3	428	3	SPTLC1	9	94809522	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	323212	94809522	46403909	249	1718										
KIAA1529	57653	broad.mit.edu	37	chr9	100079488	100079488	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctggaaggctctcaagaagGaggccctgctgcagagtttc	13	11	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:100079488G>T	uc011lut.1	+	21	2259	c.1486G>T	c.(1486-1488)GAG>TAG	p.E496*	KIAA1529_uc004axe.1_Nonsense_Mutation_p.E496*|KIAA1529_uc004axg.1_Nonsense_Mutation_p.E357*|KIAA1529_uc011lus.1_Nonsense_Mutation_p.E314*|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Nonsense_Mutation_p.E357*|KIAA1529_uc011luv.1_Nonsense_Mutation_p.E354*	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCTCAAGAAGGAGGCCCTGCT	0.632													1	0	0.00024832	0.009096	0.000254971	4	29										T	100079488	G	T	100079488	4	4	7	1	0	0	0	0	0	1	0	0	8240	1175	41	3	1532	3	KIAA1529	9	100079488	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5269966	100079488	41133943	250	1719										
ZFP37	7539	broad.mit.edu	37	chr9	115805729	115805729	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcacatgttgaataaggtttGagctgtgtctgaaggttttc	11	5	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:115805729G>C	uc004bgm.1	-	4	1197	c.1169C>G	c.(1168-1170)TCA>TGA	p.S390*	ZFP37_uc011lwz.1_Nonsense_Mutation_p.S405*|ZFP37_uc011lxa.1_Nonsense_Mutation_p.S391*	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	390	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AATAAGGTTTGAGCTGTGTCT	0.413													0	0	0	0.004007	0	16	84										C	115805729	G	C	115805729	4	2	7	1	0	0	0	0	0	1	0	0	17645	1294	45	1	727	1	ZFP37	9	115805729	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	15726241	115805729	25407702	251	1720										
ASTN2	23245	broad.mit.edu	37	chr9	119770438	119770438	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccacagaggtccctcacccaTggggaggtggcattgatctg	13	12	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:119770438T>G	uc004bjs.1	-	7	1625	c.1524A>C	c.(1522-1524)CCA>CCC	p.P508P	ASTN2_uc004bjr.1_Silent_p.P508P|ASTN2_uc004bjt.1_Silent_p.P457P	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	508	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CCCTCACCCATGGGGAGGTGG	0.577													0	0	0	0.004672	0	3	55										G	119770438	T	G	119770438	2	3	7	1	0	0	0	0	0	0	0	1	1065	1451	51	5		5	ASTN2	9	119770438	Silent	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	3964709	119770438	21442993	252	1721										
GARNL3	84253	broad.mit.edu	37	chr9	130111209	130111209	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtattgcctcacagccgtggGagccccagtgtttctgcagt	12	12	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:130111209G>A	uc011mae.1	+	17	1839	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	GARNL3_uc011mad.1_Missense_Mutation_p.E458K	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	480					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ACAGCCGTGGGAGCCCCAGTG	0.517													0	0	0	0.001168	0	5	27										A	130111209	G	A	130111209	3	1	7	1	0	0	0	0	1	0	0	0	6241	1175	41	1	1504	1	GARNL3	9	130111209	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	10340771	130111209	11102222	253	1722										
SH2D3C	10044	broad.mit.edu	37	chr9	130536540	130536540	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgctttcttgatgctggggcGaggcatggtgcccatgtggc	16	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:130536540G>A	uc004bsc.2	-	2	386	c.244C>T	c.(244-246)CGC>TGC	p.R82C	SH2D3C_uc004bsa.2_5'Flank|SH2D3C_uc004bsb.2_5'Flank|SH2D3C_uc004bsd.1_Missense_Mutation_p.R26C	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	82					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						ATGCTGGGGCGAGGCATGGTG	0.637													0	0	0	0.004007	0	16	29										A	130536540	G	A	130536540	3	1	7	1	0	0	0	0	1	0	0	0	14234	1058	37	1	2515	1	SH2D3C	9	130536540	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	425331	130536540	10676891	254	1723										
NUP214	8021	broad.mit.edu	37	chr9	134003045	134003045	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggtggagccagtggcttgcaGatttttcctactaaaaatct	10	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:134003045G>T	uc004cag.2	+	2	291	c.180G>T	c.(178-180)CAG>CAT	p.Q60H	NUP214_uc004cah.2_Missense_Mutation_p.Q60H|NUP214_uc004caf.1_Missense_Mutation_p.Q60H	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	60					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTGGCTTGCAGATTTTTCCTA	0.448			T	DEK|SET|ABL1	AML|T-ALL								1	0	1.01871e-10	0.008871	1.08307e-10	19	83										T	134003045	G	T	134003045	3	4	7	1	0	0	0	0	1	0	0	0	10762	933	33	3	186	3	NUP214	9	134003045	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3466505	134003045	7210386	255	1724										
NACC2	138151	broad.mit.edu	37	chr9	138903719	138903719	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctggcggcggcggagcccatGaccgtgcggtacatctccac	14	15	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:138903719G>A	uc004cgw.2	-	6	1563	c.1407C>T	c.(1405-1407)GTC>GTT	p.V469V	NACC2_uc010nbh.2_Silent_p.V108V|uc004cgv.3_5'Flank	NM_144653	NP_653254	Q96BF6	NACC2_HUMAN	BTB (POZ) domain containing 14A	469					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization	nuclear body					0						CGGAGCCCATGACCGTGCGGT	0.711													0	0	0	0.000602	0	5	2										A	138903719	G	A	138903719	2	1	7	1	0	0	0	0	0	0	0	1	10136	1277	45	1		1	NACC2	9	138903719	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4900674	138903719	2309712	256	1725										
SEC16A	9919	broad.mit.edu	37	chr9	139371368	139371368	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccgctgggaacaggtccttCagggcagggtgaacgatgtt	15	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:139371368C>A	uc004chx.2	-	3	1009	c.700G>T	c.(700-702)GAA>TAA	p.E234*	SEC16A_uc004chv.3_5'Flank|SEC16A_uc004chw.2_Nonsense_Mutation_p.E234*|SEC16A_uc010nbn.2_Nonsense_Mutation_p.E234*|SEC16A_uc010nbo.1_Nonsense_Mutation_p.E234*	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	56					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		ACAGGTCCTTCAGGGCAGGGT	0.652													1	0	0.00136819	0.001368	0.0013986	11	28										A	139371368	C	A	139371368	4	1	7	1	0	0	0	0	0	1	0	0	13986	835	29	3	6493	3	SEC16A	9	139371368	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	467649	139371368	1842063	257	1726										
ZMYND19	116225	broad.mit.edu	37	chr9	140477494	140477494	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atagtaggtgcaagagttctCctcctcttccactacatccc	6	14	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr9:140477494C>T	uc004cno.1	-	5	703	c.481G>A	c.(481-483)GAG>AAG	p.E161K		NM_138462	NP_612471	Q96E35	ZMY19_HUMAN	zinc finger, MYND domain containing 19	161	Poly-Glu.					Golgi apparatus|plasma membrane	zinc ion binding			skin(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		CAAGAGTTCTCCTCCTCTTCC	0.527													0	0	0	0.005443	0	27	126										T	140477494	C	T	140477494	3	4	7	1	0	0	0	0	1	0	0	0	17707	864	30	1	210	1	ZMYND19	9	140477494	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1106126	140477494	735937	258	1727										
PITRM1	10531	broad.mit.edu	37	chr10	3205933	3205933	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttacctagcattgcttgggtGatagtgagtggcatgaaact	12	6	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:3205933G>A	uc010qah.1	-	6	711	c.679C>T	c.(679-681)CAC>TAC	p.H227Y	PITRM1_uc001igr.1_Missense_Mutation_p.H259Y|PITRM1_uc001igt.1_Missense_Mutation_p.H259Y|PITRM1_uc001igu.1_Missense_Mutation_p.H251Y|PITRM1_uc010qai.1_Missense_Mutation_p.H230Y|PITRM1_uc001igw.1_Missense_Mutation_p.H259Y|uc001igx.1_5'Flank			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	227					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						TTGCTTGGGTGATAGTGAGTG	0.463													0	0	0	0.00499	0	16	76										A	3205933	G	A	3205933	3	1	7	1	0	0	0	0	1	0	0	0	11953	1290	45	1	2422	1	PITRM1	10	3205933	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		3205933	132328814	259	1728										
PITRM1	10531	broad.mit.edu	37	chr10	3205948	3205948	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgggtgatagtgagtggcatGaaactgcttaagctgctccc	13	8	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:3205948G>A	uc010qah.1	-	6	696	c.664C>T	c.(664-666)CAT>TAT	p.H222Y	PITRM1_uc001igr.1_Missense_Mutation_p.H254Y|PITRM1_uc001igt.1_Missense_Mutation_p.H254Y|PITRM1_uc001igu.1_Missense_Mutation_p.H246Y|PITRM1_uc010qai.1_Missense_Mutation_p.H225Y|PITRM1_uc001igw.1_Missense_Mutation_p.H254Y|uc001igx.1_5'Flank			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	222					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						TGAGTGGCATGAAACTGCTTA	0.458													0	0	0	0.004007	0	15	72										A	3205948	G	A	3205948	3	1	7	1	0	0	0	0	1	0	0	0	11953	1290	45	1	2437	1	PITRM1	10	3205948	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	15	3205948	132328799	260	1729										
SVIL	6840	broad.mit.edu	37	chr10	29820209	29820209	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagttggcgtttctgaatgtGaagtgcacctaggaaagaca	12	7	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:29820209G>C	uc001iut.1	-	10	2771	c.2018C>G	c.(2017-2019)TCA>TGA	p.S673*	SVIL_uc001iuu.1_Nonsense_Mutation_p.S279*	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	673					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TTCTGAATGTGAAGTGCACCT	0.333													0	0	0	0.010729	0	11	51										C	29820209	G	C	29820209	4	2	7	1	0	0	0	0	0	1	0	0	15418	1294	45	1	4742	1	SVIL	10	29820209	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	26614261	29820209	105714538	261	1730										
BMS1	9790	broad.mit.edu	37	chr10	43297618	43297618	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcagagattgcttcgtgactGgaaagtgggaagatgataaa	13	4	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:43297618G>A	uc001jaj.2	+	13	2639	c.2281G>A	c.(2281-2283)GGA>AGA	p.G761R		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	761					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						CTTCGTGACTGGAAAGTGGGA	0.413													0	0	0	0.001168	0	5	36										A	43297618	G	A	43297618	3	1	7	1	0	0	0	0	1	0	0	0	1472	1349	47	2	2327	2	BMS1	10	43297618	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	13477409	43297618	92237129	262	1731										
MAPK8	5599	broad.mit.edu	37	chr10	49632597	49632597	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgcatcatgggagaaatgatCaaaggtggtgttttgttccc	12	6	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:49632597C>T	uc009xnz.2	+	7	881	c.657C>T	c.(655-657)ATC>ATT	p.I219I	MAPK8_uc001jgl.2_Silent_p.I219I|MAPK8_uc001jgm.2_Silent_p.I219I|MAPK8_uc001jgo.2_Silent_p.I219I|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Silent_p.I219I|MAPK8_uc010qgk.1_Silent_p.I219I|MAPK8_uc001jgp.2_Intron|MAPK8_uc001jgq.2_Intron	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	219	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		GAGAAATGATCAAAGGTGGTG	0.338													0	0	0	0.001168	0	6	66										T	49632597	C	T	49632597	2	4	7	1	0	0	0	0	0	0	0	1	9283	816	29	1		1	MAPK8	10	49632597	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6334979	49632597	85902150	263	1732										
ADAMTS14	140766	broad.mit.edu	37	chr10	72489913	72489913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagcctggagcaggtgtgtcGctgggcacactcccagcagc	14	14	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:72489913G>A	uc001jrh.2	+	6	1010	c.1010G>A	c.(1009-1011)CGC>CAC	p.R337H	ADAMTS14_uc001jrg.2_Missense_Mutation_p.R337H	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	337	Peptidase M12B.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						CAGGTGTGTCGCTGGGCACAC	0.652													0	0	0	0.008291	0	9	49										A	72489913	G	A	72489913	3	1	7	1	0	0	0	0	1	0	0	0	259	1087	38	2	1032	2	ADAMTS14	10	72489913	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	22857316	72489913	63044834	264	1733										
PPP3CB	5532	broad.mit.edu	37	chr10	75214185	75214185	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cataccatcaaactggtcttCaccttcagtcattagttcat	4	12	6	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:75214185C>T	uc001jue.2	-	10	1306	c.1171G>A	c.(1171-1173)GAA>AAA	p.E391K	PPP3CB_uc001juf.2_Missense_Mutation_p.E391K|PPP3CB_uc001jug.2_Missense_Mutation_p.E391K|PPP3CB_uc001jui.2_Missense_Mutation_p.E409K|PPP3CB_uc001juh.2_Missense_Mutation_p.E305K|PPP3CB_uc010qkj.1_Missense_Mutation_p.E19K	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	391										skin(1)	1	Prostate(51;0.0119)					AACTGGTCTTCACCTTCAGTC	0.328													0	0	0	0.008291	0	11	55										T	75214185	C	T	75214185	3	4	7	1	0	0	0	0	1	0	0	0	12398	835	29	1	426	1	PPP3CB	10	75214185	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2724272	75214185	60320562	265	1734										
SFTPD	6441	broad.mit.edu	37	chr10	81701777	81701777	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgctctcccttagggcctgcGaggcctcttgcccctgccga	11	18	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:81701777G>A	uc001kbh.2	-	5	526	c.483C>T	c.(481-483)CTC>CTT	p.L161L	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	161	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TAGGGCCTGCGAGGCCTCTTG	0.622													0	0	0	0.008871	0	20	79										A	81701777	G	A	81701777	2	1	7	1	0	0	0	0	0	0	0	1	14193	1045	37	1		1	SFTPD	10	81701777	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6487592	81701777	53832970	266	1735										
HIF1AN	55662	broad.mit.edu	37	chr10	102304781	102304781	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaaggttacaaacgatgcatCttattccctccggatcagtt	7	10	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:102304781C>G	uc001krj.3	+	4	726	c.651C>G	c.(649-651)ATC>ATG	p.I217M		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	217	JmjC.|Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		AACGATGCATCTTATTCCCTC	0.453													0	0	0	0.000602	0	3	91										G	102304781	C	G	102304781	3	3	7	1	0	0	0	0	1	0	0	0	7104	903	32	1	665	1	HIF1AN	10	102304781	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	20603004	102304781	33229966	267	1736										
GBF1	8729	broad.mit.edu	37	chr10	104119055	104119055	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccatgtggaaaagtcccagtCagcatctgtggagtccatcc	10	12	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:104119055C>T	uc001kux.1	+	11	1280	c.1040C>T	c.(1039-1041)TCA>TTA	p.S347L	GBF1_uc001kuw.2_3'UTR|GBF1_uc001kuy.1_Missense_Mutation_p.S347L|GBF1_uc001kuz.1_Missense_Mutation_p.S348L	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	347					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAGTCCCAGTCAGCATCTGTG	0.537													0	0	0	0.008871	0	20	40										T	104119055	C	T	104119055	3	4	7	1	0	0	0	0	1	0	0	0	6271	838	29	1	1078	1	GBF1	10	104119055	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1814274	104119055	31415692	268	1737										
XPNPEP1	7511	broad.mit.edu	37	chr10	111640657	111640657	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcacagctttggcgatgcaGatgggggtgtaaggcataca	14	7	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:111640657G>A	uc001kyp.1	-	11	1085	c.945C>T	c.(943-945)ATC>ATT	p.I315I	XPNPEP1_uc009xxt.1_Silent_p.I358I|XPNPEP1_uc001kyq.1_Silent_p.I244I|XPNPEP1_uc010qrb.1_Silent_p.I358I|XPNPEP1_uc010qra.1_Silent_p.I82I	NM_020383	NP_065116	Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1,	315					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			ovary(3)|pancreas(1)	4		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		TGGCGATGCAGATGGGGGTGT	0.567													0	0	0	0.009096	0	4	19										A	111640657	G	A	111640657	2	1	7	1	0	0	0	0	0	0	0	1	17439	932	33	1		1	XPNPEP1	10	111640657	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7521602	111640657	23894090	269	1738										
ZDHHC6	64429	broad.mit.edu	37	chr10	114205095	114205095	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatcatggccatggtagaacAtattgctataacaccaaggg	9	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:114205095A>T	uc001kzv.2	-	2	524	c.100T>A	c.(100-102)TGT>AGT	p.C34S	VTI1A_uc001kzy.2_5'Flank|VTI1A_uc001kzz.2_5'Flank|ZDHHC6_uc001kzw.2_Missense_Mutation_p.C34S|ZDHHC6_uc009xya.1_Missense_Mutation_p.C34S|VTI1A_uc001kzx.2_5'Flank	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	34	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		ATGGTAGAACATATTGCTATA	0.398													0	0	0	0.010729	0	11	32										T	114205095	A	T	114205095	3	4	7	1	0	0	0	0	1	0	0	0	17616	217	8	5	1181	5	ZDHHC6	10	114205095	Missense_Mutation	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	2564438	114205095	21329652	270	1739										
TDRD1	56165	broad.mit.edu	37	chr10	115947866	115947866	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcttcaaacccgaatggcatCaacggagaagtagttggctc	10	10	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:115947866C>T	uc001lbg.1	+	2	429	c.276C>T	c.(274-276)ATC>ATT	p.I92I	TDRD1_uc001lbf.2_Silent_p.I83I|TDRD1_uc001lbh.1_Silent_p.I83I|TDRD1_uc001lbi.1_Silent_p.I83I	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	92					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CGAATGGCATCAACGGAGAAG	0.398													0	0	0	0.001855	0	13	51										T	115947866	C	T	115947866	2	4	7	1	0	0	0	0	0	0	0	1	15727	816	29	1		1	TDRD1	10	115947866	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1742771	115947866	19586881	271	1740										
ABLIM1	3983	broad.mit.edu	37	chr10	116361688	116361688	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcagtgaatgacaggcttctCtgatgggtggtgagggtcct	16	7	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:116361688C>G	uc010qsg.1	-	2	376	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	ABLIM1_uc010qsh.1_Missense_Mutation_p.E33Q|ABLIM1_uc010qsi.1_Missense_Mutation_p.E33Q|ABLIM1_uc010qsk.1_Missense_Mutation_p.E17Q|ABLIM1_uc009xyp.2_Missense_Mutation_p.E27Q|ABLIM1_uc001lbz.1_Missense_Mutation_p.E16Q	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	93					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		ACAGGCTTCTCTGATGGGTGG	0.493													0	0	0	0.001168	0	5	39										G	116361688	C	G	116361688	3	3	7	1	0	0	0	0	1	0	0	0	94	922	32	1	2231	1	ABLIM1	10	116361688	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	413822	116361688	19173059	272	1741										
ZRANB1	54764	broad.mit.edu	37	chr10	126631257	126631257	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaaggaggaagtagtcctttGatatgtccagactctagtgc	12	7	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:126631257G>C	uc001lic.2	+	1	566	c.195G>C	c.(193-195)TTG>TTC	p.L65F	ZRANB1_uc010qug.1_Missense_Mutation_p.L91F	NM_017580	NP_060050	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	65					positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		GTAGTCCTTTGATATGTCCAG	0.413													0	0	0	0.003271	0	35	69										C	126631257	G	C	126631257	3	2	7	1	0	0	0	0	1	0	0	0	18219	1281	45	1	197	1	ZRANB1	10	126631257	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	10269569	126631257	8903490	273	1742										
DPYSL4	10570	broad.mit.edu	37	chr10	134013904	134013904	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcaccgccagcctgggcaccGacggttcacactactggagc	11	16	2	0	rs145582956		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr10:134013904G>C	uc009ybb.2	+	9	1010	c.856G>C	c.(856-858)GAC>CAC	p.D286H		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	286					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	p.D286D(2)		central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CCTGGGCACCGACGGTTCACA	0.677													0	0	0	0.001855	0	10	51										C	134013904	G	C	134013904	3	2	7	1	0	0	0	0	1	0	0	0	4749	1058	37	1	890	1	DPYSL4	10	134013904	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7382647	134013904	1520843	274	1743										
PDDC1	347862	broad.mit.edu	37	chr11	771391	771391	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accacgagcggcaggcgggcGaagccgggggccctgacgag	19	13	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:771391G>A	uc001lrc.2	-	6	511	c.486C>T	c.(484-486)TTC>TTT	p.F162F	PDDC1_uc010qwm.1_Silent_p.F112F|PDDC1_uc001lrd.2_Silent_p.F162F|PDDC1_uc001lrf.1_Missense_Mutation_p.S140L|PDDC1_uc001lrg.1_RNA|PDDC1_uc009ycg.2_Silent_p.F112F|PDDC1_uc010qwn.1_RNA|PDDC1_uc010qwo.1_RNA|PDDC1_uc010qwp.1_Silent_p.F126F|PDDC1_uc010qwq.1_Silent_p.F76F|PDDC1_uc010qwr.1_Silent_p.F162F|PDDC1_uc010qws.1_Silent_p.F112F	NM_182612	NP_872418	Q8NB37	PDDC1_HUMAN	Parkinson disease 7 domain containing 1	162						extracellular region					0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;3.66e-26)|Epithelial(43;2.43e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-19)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGGCGGGCGAAGCCGGGGG	0.701													0	0	0	0.006214	0	9	13										A	771391	G	A	771391	2	1	7	1	0	0	0	0	0	0	0	1	11629	1049	37	1		1	PDDC1	11	771391	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		771391	134235125	275	1744										
OR51D1	390038	broad.mit.edu	37	chr11	4661760	4661760	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctgtcctctcggagggcagCactcaaggctttcaacacct	10	14	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:4661760C>T	uc010qyk.1	+	1	740	c.740C>T	c.(739-741)GCA>GTA	p.A247V		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	247	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CGGAGGGCAGCACTCAAGGCT	0.537													0	0	0	0.004482	0	9	73										T	4661760	C	T	4661760	3	4	7	1	0	0	0	0	1	0	0	0	11093	710	25	2	742	2	OR51D1	11	4661760	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3890369	4661760	130344756	276	1745										
NLRP10	338322	broad.mit.edu	37	chr11	7982182	7982182	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcttctcatccgtgaaatagGagctgaagtacctcgccctc	9	13	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:7982182G>A	uc001mfv.1	-	2	994	c.977C>T	c.(976-978)TCC>TTC	p.S326F		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	326	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGTGAAATAGGAGCTGAAGTA	0.517													0	0	0	0.00278	0	22	55										A	7982182	G	A	7982182	3	1	7	1	0	0	0	0	1	0	0	0	10472	1174	41	1	994	1	NLRP10	11	7982182	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3320422	7982182	127024334	277	1746										
TMEM41B	440026	broad.mit.edu	37	chr11	9304976	9304976	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcagatgattatttttactCaaatttctgctttagttttt	4	5	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:9304976C>G	uc001mhm.2	-	7	1179	c.871G>C	c.(871-873)GAG>CAG	p.E291Q	TMEM41B_uc001mhn.1_Missense_Mutation_p.E291Q	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	291						integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		TATTTTTACTCAAATTTCTGC	0.333													0	0	0	0.004672	0	2	16										G	9304976	C	G	9304976	3	3	7	1	0	0	0	0	1	0	0	0	16162	835	29	1	8	1	TMEM41B	11	9304976	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1322794	9304976	125701540	278	1747										
TMEM41B	440026	broad.mit.edu	37	chr11	9308127	9308127	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtagttaatgagatgttctCtatgacgttcaacctgtcat	8	7	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:9308127C>G	uc001mhm.2	-	6	889	c.581G>C	c.(580-582)AGA>ACA	p.R194T	TMEM41B_uc001mhn.1_Missense_Mutation_p.R194T	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	194						integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		GAGATGTTCTCTATGACGTTC	0.303													0	0	0	0.004656	0	25	127										G	9308127	C	G	9308127	3	3	7	1	0	0	0	0	1	0	0	0	16162	913	32	1	302	1	TMEM41B	11	9308127	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3151	9308127	125698389	279	1748										
IPO7	10527	broad.mit.edu	37	chr11	9450660	9450660	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agccttagagctaacaagaaGatgtctgattgatgatagag	11	5	1	7			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:9450660G>A	uc001mho.2	+	14	1650	c.1508G>A	c.(1507-1509)AGA>AAA	p.R503K		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	503					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		CTAACAAGAAGATGTCTGATT	0.373													0	0	0	0.006122	0	19	63										A	9450660	G	A	9450660	3	1	7	1	0	0	0	0	1	0	0	0	7797	942	33	1	1562	1	IPO7	11	9450660	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	142533	9450660	125555856	280	1749										
EIF4G2	1982	broad.mit.edu	37	chr11	10820632	10820632	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcaataatttccatgtcataGaagtgcacaaaaaagcgaag	7	7	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:10820632G>C	uc001mjc.2	-	21	2982	c.2565C>G	c.(2563-2565)TTC>TTG	p.F855L	EIF4G2_uc001mjb.2_Missense_Mutation_p.F649L|EIF4G2_uc009ygf.2_Missense_Mutation_p.F649L|EIF4G2_uc001mjd.2_Missense_Mutation_p.F817L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	855	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CCATGTCATAGAAGTGCACAA	0.343													0	0	0	0.008871	0	20	57										C	10820632	G	C	10820632	3	2	7	1	0	0	0	0	1	0	0	0	5037	933	33	1	166	1	EIF4G2	11	10820632	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1369972	10820632	124185884	281	1750			2	6		4	4	4435	N	G_C	8.570702e-05
EIF4G2	1982	broad.mit.edu	37	chr11	10820954	10820954	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgggggggtttacttcactaGaaatgtactgtaagaagctg	13	5	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:10820954G>A	uc001mjc.2	-	20	2759	c.2342C>T	c.(2341-2343)TCT>TTT	p.S781F	EIF4G2_uc001mjb.2_Missense_Mutation_p.S575F|EIF4G2_uc009ygf.2_Missense_Mutation_p.S575F|EIF4G2_uc001mjd.2_Missense_Mutation_p.S743F	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	781	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TACTTCACTAGAAATGTACTG	0.423													0	0	0	0.001368	0	12	32										A	10820954	G	A	10820954	3	1	7	1	0	0	0	0	1	0	0	0	5037	942	33	1	393	1	EIF4G2	11	10820954	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	322	10820954	124185562	282	1751			2	6		4	4	4435	N	G_C	8.570702e-05
EIF4G2	1982	broad.mit.edu	37	chr11	10821742	10821742	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagacaaagtaggaagagagGaaaatgggtgccactttcta	12	5	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:10821742G>T	uc001mjc.2	-	18	2431	c.2014C>A	c.(2014-2016)CCT>ACT	p.P672T	EIF4G2_uc001mjb.2_Missense_Mutation_p.P466T|EIF4G2_uc009ygf.2_Missense_Mutation_p.P466T|EIF4G2_uc001mjd.2_Missense_Mutation_p.P634T	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	672					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AGGAAGAGAGGAAAATGGGTG	0.408													1	0	7.93312e-07	0.00245	8.31893e-07	15	40										T	10821742	G	T	10821742	3	4	7	1	0	0	0	0	1	0	0	0	5037	1174	41	3	729	3	EIF4G2	11	10821742	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	788	10821742	124184774	283	1752			2	6		4	4	4435	N	G_C	8.570702e-05
EIF4G2	1982	broad.mit.edu	37	chr11	10825066	10825066	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatctaggtcccactgtcctCattatctgacagaggcactc	7	13	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:10825066C>T	uc001mjc.2	-	9	1191	c.774G>A	c.(772-774)ATG>ATA	p.M258I	EIF4G2_uc001mjb.2_Missense_Mutation_p.M52I|EIF4G2_uc009ygf.2_Missense_Mutation_p.M52I|EIF4G2_uc001mjd.2_Missense_Mutation_p.M258I|EIF4G2_uc001mjf.1_Missense_Mutation_p.M52I|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	258	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CCACTGTCCTCATTATCTGAC	0.403													0	0	0	0.010729	0	10	56										T	10825066	C	T	10825066	3	4	7	1	0	0	0	0	1	0	0	0	5037	826	29	1	2005	1	EIF4G2	11	10825066	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3324	10825066	124181450	284	1753			2	6		4	4	4435	N	G_C	8.570702e-05
PLEKHA7	144100	broad.mit.edu	37	chr11	16812671	16812671	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatggtggcctctcttggcaGaggcggcacagccgggggct	18	11	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:16812671G>A	uc001mmo.2	-	20	2836	c.2821C>T	c.(2821-2823)CTG>TTG	p.L941L	PLEKHA7_uc010rcu.1_Silent_p.L942L|PLEKHA7_uc001mmm.2_Silent_p.L44L|PLEKHA7_uc010rcv.1_Silent_p.L516L|PLEKHA7_uc001mmn.2_Silent_p.L650L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	941	Pro-rich.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TCTCTTGGCAGAGGCGGCACA	0.637													0	0	0	0.001984	0	7	29										A	16812671	G	A	16812671	2	1	7	1	0	0	0	0	0	0	0	1	12061	933	33	1		1	PLEKHA7	11	16812671	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5987605	16812671	118193845	285	1754										
KIF18A	81930	broad.mit.edu	37	chr11	28045346	28045346	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaattatcttgtcgaacacgTttggcaaatccagaatttac	7	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:28045346T>A	uc001msc.2	-	16	2738	c.2556A>T	c.(2554-2556)AAA>AAT	p.K852N		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	852					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						GTCGAACACGTTTGGCAAATC	0.323													0	0	0	0.001984	0	6	44										A	28045346	T	A	28045346	3	1	7	1	0	0	0	0	1	0	0	0	8280	1722	60	5	148	5	KIF18A	11	28045346	Missense_Mutation	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	11232675	28045346	106961170	286	1755										
CAT	847	broad.mit.edu	37	chr11	34470812	34470812	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgttattacagtagggccccGtgggccccttcttgttcagg	12	11	2	0	rs148918137	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:34470812G>A	uc001mvm.2	+	2	223	c.140G>A	c.(139-141)CGT>CAT	p.R47H	CAT_uc009ykc.1_RNA	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	47					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	GTAGGGCCCCGTGGGCCCCTT	0.473													0	0	0	0.004007	0	17	72										A	34470812	G	A	34470812	3	1	7	1	0	0	0	0	1	0	0	0	2686	1145	40	2	146	2	CAT	11	34470812	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6425466	34470812	100535704	287	1756										
PSMC3	5702	broad.mit.edu	37	chr11	47446777	47446777	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tggagctcatgggtgactctCaacacttcactcttcatgat	8	11	5	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:47446777C>G	uc001nfh.2	-	3	374	c.180G>C	c.(178-180)TTG>TTC	p.L60F	PSMC3_uc009ylr.1_Intron	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	60					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GGGTGACTCTCAACACTTCAC	0.473													0	0	0	0.00245	0	15	89										G	47446777	C	G	47446777	3	3	7	1	0	0	0	0	1	0	0	0	12687	825	29	1	1179	1	PSMC3	11	47446777	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	12975965	47446777	87559739	288	1757										
PTPRJ	5795	broad.mit.edu	37	chr11	48134415	48134415	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agaatggaactggaacacctCaggtggaaacaaacaccagt	10	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:48134415C>G	uc001ngp.3	+	3	587	c.232C>G	c.(232-234)CAG>GAG	p.Q78E	PTPRJ_uc001ngo.3_Missense_Mutation_p.Q78E	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	78	Extracellular (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						TGGAACACCTCAGGTGGAAAC	0.468													0	0	0	0.008871	0	19	44										G	48134415	C	G	48134415	3	3	7	1	0	0	0	0	1	0	0	0	12804	827	29	1	242	1	PTPRJ	11	48134415	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	687638	48134415	86872101	289	1758										
FOLH1	2346	broad.mit.edu	37	chr11	49229913	49229913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcgcacagccagcgcgggcGgcgcgcggtggccacagccg	18	16	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:49229913G>A	uc001ngy.2	-	1	310	c.49C>T	c.(49-51)CGC>TGC	p.R17C	FOLH1_uc001ngz.2_Missense_Mutation_p.R17C|FOLH1_uc009yly.2_5'UTR|FOLH1_uc009ylz.2_5'UTR|FOLH1_uc009yma.2_5'UTR|FOLH1_uc001nha.2_5'UTR	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	17	Cytoplasmic (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CAGCGCGGGCGGCGCGCGGTG	0.711													0	0	0	0.004672	0	3	7										A	49229913	G	A	49229913	3	1	7	1	0	0	0	0	1	0	0	0	5979	1116	39	2	2279	2	FOLH1	11	49229913	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1095498	49229913	85776603	290	1759										
OR5M10	390167	broad.mit.edu	37	chr11	56344784	56344784	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accagagagatgcaaatgttCttggacatcctggaactgta	10	8	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:56344784C>G	uc001niz.1	-	1	414	c.414G>C	c.(412-414)AAG>AAC	p.K138N		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCAAATGTTCTTGGACATCC	0.468													0	0	0	0.000602	0	4	91										G	56344784	C	G	56344784	3	3	7	1	0	0	0	0	1	0	0	0	11173	912	32	1	537	1	OR5M10	11	56344784	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7114871	56344784	78661732	291	1760										
OR9I1	219954	broad.mit.edu	37	chr11	57886441	57886441	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggtgaaggtgcaagtggtaCgcaggatggctcctgacacc	16	9	0	2	rs139300657	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:57886441C>T	uc001nml.1	-	1	476	c.476G>A	c.(475-477)CGT>CAT	p.R159H	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				GCAAGTGGTACGCAGGATGGC	0.542													0	0	0	0.001984	0	7	53										T	57886441	C	T	57886441	3	4	7	1	0	0	0	0	1	0	0	0	11253	536	19	2	472	2	OR9I1	11	57886441	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1541657	57886441	77120075	292	1761										
OR1S2	219958	broad.mit.edu	37	chr11	57970695	57970695	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcaaagggaagaaatttttCtattgatgagctttctcagg	9	5	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:57970695C>G	uc010rkb.1	-	1	959	c.959G>C	c.(958-960)AGA>ACA	p.R320T		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	320	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				AGAAATTTTTCTATTGATGAG	0.428													0	0	0	0.008291	0	10	97										G	57970695	C	G	57970695	3	3	7	1	0	0	0	0	1	0	0	0	10973	913	32	1	21	1	OR1S2	11	57970695	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	84254	57970695	77035821	293	1762										
CCDC86	79080	broad.mit.edu	37	chr11	60617418	60617418	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcccacatgttccaggagaaGaaacagcgccgggctgagaa	12	11	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:60617418G>T	uc001nqa.2	+	3	1063	c.894G>T	c.(892-894)AAG>AAT	p.K298N	CCDC86_uc001nqb.2_Missense_Mutation_p.K42N	NM_024098	NP_077003	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	298	Potential.				interspecies interaction between organisms	nucleus					0						TCCAGGAGAAGAAACAGCGCC	0.607													1	0	0.00198382	0.001984	0.0020249	5	18										T	60617418	G	T	60617418	3	4	7	1	0	0	0	0	1	0	0	0	2861	933	33	3	904	3	CCDC86	11	60617418	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2646723	60617418	74389098	294	1763										
FADS1	3992	broad.mit.edu	37	chr11	61580081	61580081	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagaagacatggttggccttCatgagccccatccgctccac	9	14	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:61580081C>T	uc010rlm.1	-	3	674	c.546G>A	c.(544-546)ATG>ATA	p.M182I	FADS1_uc001nsh.2_Missense_Mutation_p.M41I|FADS1_uc010rln.1_Missense_Mutation_p.M41I	NM_013402	NP_037534	O60427	FADS1_HUMAN	fatty acid desaturase 1	125	Helical; (Potential).				cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)	1					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	GGTTGGCCTTCATGAGCCCCA	0.552													0	0	0	0.00308	0	6	23										T	61580081	C	T	61580081	3	4	7	1	0	0	0	0	1	0	0	0	5365	826	29	1	999	1	FADS1	11	61580081	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	962663	61580081	73426435	295	1764										
C11orf48	79081	broad.mit.edu	37	chr11	62437250	62437250	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tggattccaccacaatagacGgcagatgggacttttgagag	12	8	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:62437250G>C	uc001nue.2	-	3	611	c.176C>G	c.(175-177)CCG>CGG	p.P59R	C11orf48_uc001nuf.2_Missense_Mutation_p.P59R|C11orf48_uc010rmd.1_Missense_Mutation_p.P59R|C11orf83_uc001nui.3_5'Flank	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081	85											0						CACAATAGACGGCAGATGGGA	0.532													0	0	0	0.001984	0	6	111										C	62437250	G	C	62437250	3	2	7	1	0	0	0	0	1	0	0	0	1644	1116	39	4	635	4	C11orf48	11	62437250	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	857169	62437250	72569266	296	1765										
NXF1	10482	broad.mit.edu	37	chr11	62569095	62569095	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagccatcgtatcgtttgctCatgatcagctagaggaaaaa	10	8	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:62569095C>G	uc001nvf.1	-	7	784	c.648G>C	c.(646-648)ATG>ATC	p.M216I	NXF1_uc001nvg.1_Missense_Mutation_p.M216I|NXF1_uc009yog.1_Missense_Mutation_p.M259I|NXF1_uc010rmh.1_Missense_Mutation_p.M79I	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	216	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						ATCGTTTGCTCATGATCAGCT	0.493													0	0	0	0.012319	0	23	80										G	62569095	C	G	62569095	3	3	7	1	0	0	0	0	1	0	0	0	10782	826	29	1	1326	1	NXF1	11	62569095	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	131845	62569095	72437421	297	1766										
RTN3	10313	broad.mit.edu	37	chr11	63487538	63487538	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaaataacaaaattcaggctGaaaaacctgtttccattcca	4	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:63487538G>A	uc001nxq.2	+	3	1751	c.1564G>A	c.(1564-1566)GAA>AAA	p.E522K	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.E503K|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.E410K|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	522					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						AATTCAGGCTGAAAAACCTGT	0.368													0	0	0	0.009096	0	3	32										A	63487538	G	A	63487538	3	1	7	1	0	0	0	0	1	0	0	0	13727	1291	45	1	1574	1	RTN3	11	63487538	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	918443	63487538	71518978	298	1767										
KCNK4	50801	broad.mit.edu	37	chr11	64067068	64067068	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggccttcatcgacgagtcctCggatacgcagagcgagcgcg	14	13	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:64067068C>G	uc001nzj.1	+	7	1375	c.1052C>G	c.(1051-1053)TCG>TGG	p.S351W	KCNK4_uc001nzk.1_Silent_p.L235L|KCNK4_uc010rnk.1_Missense_Mutation_p.S179W|KCNK4_uc001nzl.1_Silent_p.L235L|KCNK4_uc001nzm.3_RNA|KCNK4_uc001nzn.1_Missense_Mutation_p.S351W|KCNK4_uc001nzo.2_Missense_Mutation_p.S351W|KCNK4_uc001nzp.1_Missense_Mutation_p.S237W|C11orf20_uc009ypm.2_5'Flank	NM_033310	NP_201567	Q9NYG8	KCNK4_HUMAN	TRAAK	351	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						GACGAGTCCTCGGATACGCAG	0.652													0	0	0	0.00245	0	11	32										G	64067068	C	G	64067068	3	3	7	1	0	0	0	0	1	0	0	0	8068	893	31	1	1074	1	KCNK4	11	64067068	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	579530	64067068	70939448	299	1768										
ATG2A	23130	broad.mit.edu	37	chr11	64669472	64669472	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcatcaaggatgcagaactCatcactgtccagggtgtctc	10	11	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:64669472C>T	uc001obx.2	-	29	4196	c.4081G>A	c.(4081-4083)GAG>AAG	p.E1361K	ATG2A_uc001obw.2_Missense_Mutation_p.E126K	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1361							protein binding			ovary(1)|central_nervous_system(1)	2						ATGCAGAACTCATCACTGTCC	0.622													0	0	0	0.006214	0	9	74										T	64669472	C	T	64669472	3	4	7	1	0	0	0	0	1	0	0	0	1093	835	29	1	1787	1	ATG2A	11	64669472	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	602404	64669472	70337044	300	1769										
C11orf85	283129	broad.mit.edu	37	chr11	64708057	64708057	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggacctaccttgtttctggAcatcagtgatatcagaggcc	10	10	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:64708057A>C	uc001ocb.1	-	8	609	c.535T>G	c.(535-537)TCC>GCC	p.S179A	C11orf85_uc001occ.1_RNA|C11orf85_uc001ocd.1_Missense_Mutation_p.V122G	NM_001037225	NP_001032302	Q3KP22	CK085_HUMAN	hypothetical protein LOC283129	179											0						TTGTTTCTGGACATCAGTGAT	0.408													0	0	0	0.008871	0	17	78										C	64708057	A	C	64708057	3	2	7	1	0	0	0	0	1	0	0	0	1668	275	10	5	123	5	C11orf85	11	64708057	Missense_Mutation	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	38585	64708057	70298459	301	1770										
FIBP	9158	broad.mit.edu	37	chr11	65651873	65651873	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggctgctcaccggaagccatCgagggagtggacagacgctg	16	11	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:65651873C>T	uc001ogd.2	-	9	1136	c.1015G>A	c.(1015-1017)GAT>AAT	p.D339N	FIBP_uc009yqu.2_Missense_Mutation_p.R324Q|FIBP_uc001oge.2_Missense_Mutation_p.D332N	NM_198897	NP_942600	O43427	FIBP_HUMAN	FGF intracellular binding protein isoform a	339					fibroblast growth factor receptor signaling pathway	endomembrane system|membrane|microsome|mitochondrion|nucleus	fibroblast growth factor binding			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.166)		CGGAAGCCATCGAGGGAGTGG	0.627											OREG0021089	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	25										T	65651873	C	T	65651873	3	4	7	1	0	0	0	0	1	0	0	0	5886	884	31	1	87	1	FIBP	11	65651873	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	943816	65651873	69354643	302	1771										
RBM4B	83759	broad.mit.edu	37	chr11	66436149	66436149	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgctcccgttcataccgggcCatgtcatacagagaattccg	9	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:66436149C>T	uc001oja.2	-	2	1695	c.1026G>A	c.(1024-1026)ATG>ATA	p.M342I	RBM4B_uc001ojb.2_Missense_Mutation_p.M342I	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	342	Interaction with TNPO3 (By similarity).				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						CATACCGGGCCATGTCATACA	0.517													0	0	0	0.00245	0	12	32										T	66436149	C	T	66436149	3	4	7	1	0	0	0	0	1	0	0	0	13142	594	21	2	57	2	RBM4B	11	66436149	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	784276	66436149	68570367	303	1772										
CPT1A	1374	broad.mit.edu	37	chr11	68525189	68525189	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttcaggtgccttccaaagcGatgagaatcctttcatgtaa	8	9	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:68525189G>A	uc001oog.3	-	19	2415	c.2245C>T	c.(2245-2247)CGC>TGC	p.R749C	CPT1A_uc001oof.3_Intron|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	749	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CTTCCAAAGCGATGAGAATCC	0.398													0	0	0	0.00308	0	8	74										A	68525189	G	A	68525189	3	1	7	1	0	0	0	0	1	0	0	0	3831	1058	37	1	120	1	CPT1A	11	68525189	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2089040	68525189	66481327	304	1773										
IGHMBP2	3508	broad.mit.edu	37	chr11	68703931	68703931	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aactcccagggttccagccaCgctgccaccaagccccaggg	10	18	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:68703931C>T	uc001ook.1	+	13	2085	c.1983C>T	c.(1981-1983)CAC>CAT	p.H661H	IGHMBP2_uc001ool.1_Silent_p.H285H|IGHMBP2_uc001oom.1_Silent_p.H239H	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	661	SS DNA-binding (By similarity).				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTTCCAGCCACGCTGCCACCA	0.597													0	0	0	0.008871	0	18	72										T	68703931	C	T	68703931	2	4	7	1	0	0	0	0	0	0	0	1	7591	535	19	2		2	IGHMBP2	11	68703931	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	178742	68703931	66302585	305	1774										
CCND1	595	broad.mit.edu	37	chr11	69456203	69456203	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggaggagacctgcgcgccctCggtgtcctacttcaaatgtg	13	12	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:69456203C>T	uc001opa.2	+	1	331	c.122C>T	c.(121-123)TCG>TTG	p.S41L		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	41	Cyclin N-terminal.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	TGCGCGCCCTCGGTGTCCTAC	0.652			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			0	0	0	0.006122	0	15	63										T	69456203	C	T	69456203	3	4	7	1	0	0	0	0	1	0	0	0	2916	893	31	1	124	1	CCND1	11	69456203	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	752272	69456203	65550313	306	1775										
NUMA1	4926	broad.mit.edu	37	chr11	71715792	71715792	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggattggctgcatgctggctCggcgcagggtctcttggggg	19	9	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:71715792C>T	uc001orl.1	-	24	6072	c.5900G>A	c.(5899-5901)CGA>CAA	p.R1967Q	IL18BP_uc009ysu.1_Intron|NUMA1_uc001orj.2_Missense_Mutation_p.R149Q|NUMA1_uc009ysw.1_Missense_Mutation_p.R1534Q|NUMA1_uc001ork.1_Missense_Mutation_p.R831Q|NUMA1_uc001orm.1_Missense_Mutation_p.R1953Q	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1967					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CATGCTGGCTCGGCGCAGGGT	0.627			T	RARA	APL								0	0	0	0.00499	0	17	27										T	71715792	C	T	71715792	3	4	7	1	0	0	0	0	1	0	0	0	10750	884	31	1	463	1	NUMA1	11	71715792	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2259589	71715792	63290724	307	1776										
P2RY2	5029	broad.mit.edu	37	chr11	72945966	72945966	+	Silent	SNP	C	C	T													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccgtggtgctggctgtcttCgccctctgcttcctgccatt							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:72945966C>T	uc001otj.2	+	3	1095	c.762C>T	c.(760-762)TTC>TTT	p.F254F	P2RY2_uc001otk.2_Silent_p.F254F|P2RY2_uc001otl.2_Silent_p.F254F	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	254	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	TGGCTGTCTTCGCCCTCTGCT	0.652													0	0	0	0.009096	0	4	42										T	72945966	C	T	72945966	2	4	7	1	0	0	0	0	0	0	0	1	11352	883	31	1		1	P2RY2	11	72945966	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1230174	72945966	62060550	308	1777	12	2								
P2RY2	5029	broad.mit.edu	37	chr11	72945972	72945972	+	Silent	SNP	C	C	G													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgctggctgtcttcgccctCtgcttcctgccattccacgt							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:72945972C>G	uc001otj.2	+	3	1101	c.768C>G	c.(766-768)CTC>CTG	p.L256L	P2RY2_uc001otk.2_Silent_p.L256L|P2RY2_uc001otl.2_Silent_p.L256L	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	256	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	TCTTCGCCCTCTGCTTCCTGC	0.647													0	0	0	0.004672	0	3	44										G	72945972	C	G	72945972	2	3	7	1	0	0	0	0	0	0	0	1	11352	900	32	1		1	P2RY2	11	72945972	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6	72945972	62060544	309	1778	12	2								
PAAF1	80227	broad.mit.edu	37	chr11	73627688	73627688	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatggaaacatttatcagctGgatgtgaggagtccaaggtg	14	5	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:73627688G>A	uc001ouk.1	+	9	952	c.918G>A	c.(916-918)CTG>CTA	p.L306L	PAAF1_uc001oul.1_Silent_p.L289L|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Silent_p.L289L|PAAF1_uc001oun.1_5'Flank	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	306	WD 4.				interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					TTTATCAGCTGGATGTGAGGA	0.423													0	0	0	0.000602	0	4	41										A	73627688	G	A	73627688	2	1	7	1	0	0	0	0	0	0	0	1	11362	1335	47	2		2	PAAF1	11	73627688	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	681716	73627688	61378828	310	1779										
SYTL2	54843	broad.mit.edu	37	chr11	85445395	85445395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	catgctttaatggctccaggGagtttggggaagagttgtct	14	6	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:85445395G>A	uc010rth.1	-	6	1250	c.974C>T	c.(973-975)TCC>TTC	p.S325F	SYTL2_uc010rtg.1_Missense_Mutation_p.S326F|SYTL2_uc010rti.1_Missense_Mutation_p.S325F|SYTL2_uc010rtj.1_Missense_Mutation_p.S277F|SYTL2_uc001pbf.3_Missense_Mutation_p.S325F|SYTL2_uc010rtf.1_Missense_Mutation_p.S183F	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	325					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGCTCCAGGGAGTTTGGGGA	0.448													0	0	0	0.00333	0	23	83										A	85445395	G	A	85445395	3	1	7	1	0	0	0	0	1	0	0	0	15480	1174	41	1	4363	1	SYTL2	11	85445395	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	11817707	85445395	49561121	311	1780										
HEPHL1	341208	broad.mit.edu	37	chr11	93778980	93778980	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggattcctgggccccatcttGagggccgaagtgggtgatgt	16	9	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:93778980G>A	uc001pep.2	+	2	469	c.312G>A	c.(310-312)TTG>TTA	p.L104L		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	104	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GCCCCATCTTGAGGGCCGAAG	0.468													0	0	0	0.008291	0	10	22										A	93778980	G	A	93778980	2	1	7	1	0	0	0	0	0	0	0	1	7055	1281	45	1		1	HEPHL1	11	93778980	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8333585	93778980	41227536	312	1781										
HEPHL1	341208	broad.mit.edu	37	chr11	93844129	93844129	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgggacattccaaaccattGaactgtttgcagatcaccca	7	12	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:93844129G>A	uc001pep.2	+	18	3263	c.3106G>A	c.(3106-3108)GAA>AAA	p.E1036K	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	1036	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CCAAACCATTGAACTGTTTGC	0.438													0	0	0	0.008291	0	9	14										A	93844129	G	A	93844129	3	1	7	1	0	0	0	0	1	0	0	0	7055	1291	45	1	3176	1	HEPHL1	11	93844129	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	65149	93844129	41162387	313	1782										
MMP8	4317	broad.mit.edu	37	chr11	102584518	102584518	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aactgcatcaactttactctCtattcctggaaaggcacctg	6	12	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:102584518C>G	uc001phe.2	-	9	1360	c.1261G>C	c.(1261-1263)GAG>CAG	p.E421Q	MMP8_uc010rut.1_Nonstop_Mutation_p.*304Y|MMP8_uc010ruu.1_Missense_Mutation_p.E398Q	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	421	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ACTTTACTCTCTATTCCTGGA	0.313													0	0	0	0.003163	0	14	71										G	102584518	C	G	102584518	3	3	7	1	0	0	0	0	1	0	0	0	9668	922	32	1	150	1	MMP8	11	102584518	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	8740389	102584518	32421998	314	1783										
GUCY1A2	2977	broad.mit.edu	37	chr11	106849346	106849346	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atatatatagttaatataccGagtatattagcagtacactg	6	5	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:106849346G>A	uc001pjg.1	-	3	876	c.486C>T	c.(484-486)CTC>CTT	p.L162L	GUCY1A2_uc010rvo.1_Silent_p.L162L|GUCY1A2_uc009yxn.1_Silent_p.L162L	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	162					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TTAATATACCGAGTATATTAG	0.368													0	0	0	0.009096	0	3	22										A	106849346	G	A	106849346	2	1	7	1	0	0	0	0	0	0	0	1	6893	1072	37	1		1	GUCY1A2	11	106849346	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4264828	106849346	28157170	315	1784										
TTC12	54970	broad.mit.edu	37	chr11	113210177	113210177	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctggggggattgagatcctGactgaaatgataaatgagtg	15	4	0	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:113210177G>C	uc001pnu.2	+	10	912	c.807G>C	c.(805-807)CTG>CTC	p.L269L	TTC12_uc001pnv.2_Silent_p.L275L|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Silent_p.L119L	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	269							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TTGAGATCCTGACTGAAATGA	0.498													0	0	0	0.001368	0	11	52										C	113210177	G	C	113210177	2	2	7	1	0	0	0	0	0	0	0	1	16676	1277	45	1		1	TTC12	11	113210177	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6360831	113210177	21796339	316	1785										
CLDN25	644672	broad.mit.edu	37	chr11	113650985	113650985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatgacagcatccctgacatCatacctcggtgggagtttgg	12	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:113650985C>G	uc009yyw.1	+	1	468	c.468C>G	c.(466-468)ATC>ATG	p.I156M		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	156	Extracellular (Potential).					integral to membrane|tight junction	structural molecule activity				0						TCCCTGACATCATACCTCGGT	0.582													0	0	0	0.001168	0	6	26										G	113650985	C	G	113650985	3	3	7	1	0	0	0	0	1	0	0	0	3485	816	29	1	470	1	CLDN25	11	113650985	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	440808	113650985	21355531	317	1786										
CLDN25	644672	broad.mit.edu	37	chr11	113651015	113651015	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgggagtttggaggtgccctCtacttgggctgggctgctgg	18	8	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:113651015C>G	uc009yyw.1	+	1	498	c.498C>G	c.(496-498)CTC>CTG	p.L166L		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	166	Helical; (Potential).					integral to membrane|tight junction	structural molecule activity				0						GAGGTGCCCTCTACTTGGGCT	0.557													0	0	0	0.006214	0	10	17										G	113651015	C	G	113651015	2	3	7	1	0	0	0	0	0	0	0	1	3485	900	32	1		1	CLDN25	11	113651015	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	30	113651015	21355501	318	1787										
APOA5	116519	broad.mit.edu	37	chr11	116661323	116661323	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agccacactgcggtgcagctCctgcacgtggcgcccgatgc	13	16	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:116661323C>G	uc001ppr.2	-	3	630	c.622G>C	c.(622-624)GAG>CAG	p.E208Q	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Missense_Mutation_p.E208Q|APOA5_uc009yzf.2_Missense_Mutation_p.E208Q|APOA5_uc009yzg.2_Missense_Mutation_p.E234Q	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	208					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		CGGTGCAGCTCCTGCACGTGG	0.706													0	0	0	0.006214	0	9	14										G	116661323	C	G	116661323	3	3	7	1	0	0	0	0	1	0	0	0	784	864	30	1	482	1	APOA5	11	116661323	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3010308	116661323	18345193	319	1788										
UBE4A	9354	broad.mit.edu	37	chr11	118267074	118267074	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtcccctcaccatggaccaGatccggccaaacacagaact	7	16	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:118267074G>C	uc001psw.2	+	20	3249	c.3120G>C	c.(3118-3120)CAG>CAC	p.Q1040H	UBE4A_uc001psv.2_Missense_Mutation_p.Q1047H	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	1040	U-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CCATGGACCAGATCCGGCCAA	0.418													0	0	0	0.006214	0	6	60										C	118267074	G	C	118267074	3	2	7	1	0	0	0	0	1	0	0	0	16879	933	33	1	3215	1	UBE4A	11	118267074	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1605751	118267074	16739442	320	1789										
UBE4A	9354	broad.mit.edu	37	chr11	118267125	118267125	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atccaacggtggcttgcagaGaggaaacaacaaaaggagca	12	8	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:118267125G>C	uc001psw.2	+	20	3300	c.3171G>C	c.(3169-3171)GAG>GAC	p.E1057D	UBE4A_uc001psv.2_Missense_Mutation_p.E1064D	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	1057					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		GGCTTGCAGAGAGGAAACAAC	0.438													0	0	0	0.006214	0	7	48										C	118267125	G	C	118267125	3	2	7	1	0	0	0	0	1	0	0	0	16879	933	33	1	3266	1	UBE4A	11	118267125	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	51	118267125	16739391	321	1790										
MLL	4297	broad.mit.edu	37	chr11	118373957	118373969	+	Frame_Shift_Del	DEL	GGAACCTGGTCAG	GGAACCTGGTCAG	-													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cattccagtaaatcttttttGgaacctggtcaggtgacaac							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			GGAACCTGGTCAG	-	GGAACCTGGTCAG	GGAACCTGGTCAG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:118373957_118373969delGGAACCTGGTCAG	uc001pta.2	+	27	7364_7376	c.7341_7353delGGAACCTGGTCAG	c.(7339-7353)TTGGAACCTGGTCAGfs	p.L2447fs	MLL_uc001ptb.2_Frame_Shift_Del_p.L2450fs	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2447_2451					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AATCTTTTTTGGAACCTGGTCAGGTGACAACTG	0.404			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL													14	53	---	---								-	118373969	GGAACCTGGTCAG	-	118373957	7	5	7	1	0	1	0	1	0	0	0	0	9620	1339	47	0	7447	0	MLL	11	118373957	Frame_Shift_Del	DEL	GGAACCTGGTCAG	TCGA-BT-A20J-01A-11D-A14W-08	106832	118373957	16632559	322	1791										
MFRP	83552	broad.mit.edu	37	chr11	119212379	119212379	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctccgcttcctggcagacaGagcggcaagggggcagaaca	15	12	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:119212379G>C	uc001pwj.2	-	13	1779	c.1619C>G	c.(1618-1620)TCT>TGT	p.S540C	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.S422C	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CTGGCAGACAGAGCGGCAAGG	0.647													0	0	0	0.001855	0	14	26										C	119212379	G	C	119212379	3	2	7	1	0	0	0	0	1	0	0	0	9526	942	33	1	124	1	MFRP	11	119212379	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	838422	119212379	15794137	323	1792										
OR10G9	219870	broad.mit.edu	37	chr11	123893845	123893845	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	actgtgctggggaacctcctCatcctgctggtgatcagggt	13	11	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:123893845C>A	uc010sad.1	+	1	126	c.126C>A	c.(124-126)CTC>CTA	p.L42L		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGAACCTCCTCATCCTGCTGG	0.572													1	0	3.1745e-13	0.008361	3.38548e-13	25	62										A	123893845	C	A	123893845	2	1	7	1	0	0	0	0	0	0	0	1	10904	813	29	3		3	OR10G9	11	123893845	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4681466	123893845	11112671	324	1793										
OR10G7	390265	broad.mit.edu	37	chr11	123909583	123909583	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accctgatcaccagcaggatGaggaggttccccagcacagt	11	13	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:123909583G>T	uc001pzq.1	-	1	126	c.126C>A	c.(124-126)CTC>CTA	p.L42L		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CCAGCAGGATGAGGAGGTTCC	0.577													1	0	5.18039e-06	0.00308	5.39136e-06	5	54										T	123909583	G	T	123909583	2	4	7	1	0	0	0	0	0	0	0	1	10902	1277	45	3		3	OR10G7	11	123909583	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	15738	123909583	11096933	325	1794										
VWA5A	4013	broad.mit.edu	37	chr11	124012328	124012328	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcgaaaggccttacactctGaccgtcctccttctgcatct	6	15	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:124012328G>C	uc001pzu.2	+	16	2112	c.1903G>C	c.(1903-1905)GAC>CAC	p.D635H	VWA5A_uc001pzt.2_Missense_Mutation_p.D635H	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	635										upper_aerodigestive_tract(1)|ovary(1)	2						CTTACACTCTGACCGTCCTCC	0.463													0	0	0	0.005443	0	25	47										C	124012328	G	C	124012328	3	2	7	1	0	0	0	0	1	0	0	0	17239	1290	45	1	1961	1	VWA5A	11	124012328	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	102745	124012328	10994188	326	1795										
OR8D1	283159	broad.mit.edu	37	chr11	124179832	124179832	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atggggatcaccgtggtgtaGaacacagaggacaccttctc	12	10	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:124179832G>C	uc010sag.1	-	1	831	c.831C>G	c.(829-831)TTC>TTG	p.F277L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CCGTGGTGTAGAACACAGAGG	0.453													0	0	0	0.002299	0	22	30										C	124179832	G	C	124179832	3	2	7	1	0	0	0	0	1	0	0	0	11231	933	33	1	98	1	OR8D1	11	124179832	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	167504	124179832	10826684	327	1796										
ACAD8	27034	broad.mit.edu	37	chr11	134131719	134131719	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagcagtggctctgcaggagGagaggaaggatgcagtggcc	18	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:134131719G>A	uc001qhk.2	+	9	1088	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.E266K|ACAD8_uc001qhl.2_Missense_Mutation_p.E216K	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	343					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		TCTGCAGGAGGAGAGGAAGGA	0.567													0	0	0	0.00245	0	14	27										A	134131719	G	A	134131719	3	1	7	1	0	0	0	0	1	0	0	0	110	1175	41	1	1061	1	ACAD8	11	134131719	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	9951887	134131719	874797	328	1797										
GLB1L2	89944	broad.mit.edu	37	chr11	134244148	134244148	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgacacctttctgaagctgGaggttggtaacgcccttttc	11	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr11:134244148G>T	uc001qhp.2	+	17	1893	c.1705G>T	c.(1705-1707)GAG>TAG	p.E569*	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	569					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		TCTGAAGCTGGAGGTTGGTAA	0.567													1	0	3.59834e-05	0.001168	3.71684e-05	6	86										T	134244148	G	T	134244148	4	4	7	1	0	0	0	0	0	1	0	0	6429	1175	41	3	1771	3	GLB1L2	11	134244148	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	112429	134244148	762368	329	1798										
SLC6A13	6540	broad.mit.edu	37	chr12	331745	331745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccaacagtatttgataagagGccatggcctgtacccaatca	8	11	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:331745G>A	uc001qic.1	-	13	1521	c.1468C>T	c.(1468-1470)CCT>TCT	p.P490S	SLC6A13_uc009zdj.1_Missense_Mutation_p.P480S|SLC6A13_uc010sdl.1_Missense_Mutation_p.P398S	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	490	Helical; Name=11; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TTGATAAGAGGCCATGGCCTG	0.478													0	0	0	0.001368	0	9	11										A	331745	G	A	331745	3	1	7	1	0	0	0	0	1	0	0	0	14676	1203	42	2	352	2	SLC6A13	12	331745	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		331745	133520150	330	1799										
KCNA1	3736	broad.mit.edu	37	chr12	5021802	5021802	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atttctaccaccgagaaactGagggggaagagcaggctcag	13	9	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:5021802G>C	uc001qnh.2	+	2	2363	c.1258G>C	c.(1258-1260)GAG>CAG	p.E420Q		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	420					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCGAGAAACTGAGGGGGAAGA	0.527													0	0	0	0.001984	0	6	569										C	5021802	G	C	5021802	3	2	7	1	0	0	0	0	1	0	0	0	8001	1291	45	1	1260	1	KCNA1	12	5021802	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4690057	5021802	128830093	331	1800										
CHD4	1108	broad.mit.edu	37	chr12	6710690	6710690	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgggatttttggcagcaatGaggggtctggtggagaaatg	17	3	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:6710690G>T	uc001qpo.2	-	6	728	c.564C>A	c.(562-564)CTC>CTA	p.L188L	CHD4_uc001qpn.2_Silent_p.L181L|CHD4_uc001qpp.2_Silent_p.L185L	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	188					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TGGCAGCAATGAGGGGTCTGG	0.438													1	0	8.96267e-189	0.00361	9.61779e-189	345	360										T	6710690	G	T	6710690	2	4	7	1	0	0	0	0	0	0	0	1	3327	1277	45	3		3	CHD4	12	6710690	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1688888	6710690	127141205	332	1801										
CD163	9332	broad.mit.edu	37	chr12	7647847	7647847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagatgttttgagtgcagatCcacatcccagctgcctgcaa	9	11	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:7647847C>T	uc001qsz.3	-	6	1378	c.1250G>A	c.(1249-1251)GGA>GAA	p.G417E	CD163_uc001qta.3_Missense_Mutation_p.G417E|CD163_uc009zfw.2_Missense_Mutation_p.G417E	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	417	SRCR 4.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GAGTGCAGATCCACATCCCAG	0.468													0	0	0	0.00245	0	13	96										T	7647847	C	T	7647847	3	4	7	1	0	0	0	0	1	0	0	0	2967	855	30	1	2264	1	CD163	12	7647847	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	937157	7647847	126204048	333	1802										
A2M	2	broad.mit.edu	37	chr12	9229475	9229475	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atggctgccatggtccccttCttgtgctgtcttccaggctg	11	13	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:9229475C>G	uc001qvk.1	-	28	3522	c.3409G>C	c.(3409-3411)GAA>CAA	p.E1137Q	A2M_uc001qvj.1_Missense_Mutation_p.E179Q|A2M_uc009zgk.1_Missense_Mutation_p.E987Q	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1137					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TGGTCCCCTTCTTGTGCTGTC	0.512													0	0	0	0.001855	0	12	115										G	9229475	C	G	9229475	3	3	7	1	0	0	0	0	1	0	0	0	4	922	32	1	1051	1	A2M	12	9229475	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1581628	9229475	124622420	334	1803										
TAS2R8	50836	broad.mit.edu	37	chr12	10959334	10959334	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagaaggtaaaaatgactatCtgttgtttattttttgtata	7	3	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:10959334C>T	uc010shh.1	-	1	246	c.246G>A	c.(244-246)CAG>CAA	p.Q82Q		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	82	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						AAATGACTATCTGTTGTTTAT	0.343													0	0	0	0.006214	0	10	66										T	10959334	C	T	10959334	2	4	7	1	0	0	0	0	0	0	0	1	15584	912	32	1		1	TAS2R8	12	10959334	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1729859	10959334	122892561	335	1804										
TAS2R42	353164	broad.mit.edu	37	chr12	11339184	11339184	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcatcctccacctcagccaGaggaaaagggagtgggggaa	13	10	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:11339184G>A	uc001qzr.1	-	1	360	c.360C>T	c.(358-360)CTC>CTT	p.L120L	PRB4_uc001qzf.1_Intron	NM_181429	NP_852094	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	120	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			ACCTCAGCCAGAGGAAAAGGG	0.398													0	0	0	0.003163	0	13	27										A	11339184	G	A	11339184	2	1	7	1	0	0	0	0	0	0	0	1	15577	929	33	1		1	TAS2R42	12	11339184	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	379850	11339184	122512711	336	1805										
HEBP1	50865	broad.mit.edu	37	chr12	13142262	13142262	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaccttgggcattgcttcccGtagagcctcatccacaggct	10	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:13142262G>A	uc001rbd.2	-	2	339	c.166C>T	c.(166-168)CGG>TGG	p.R56W	HEBP1_uc001rbf.2_Missense_Mutation_p.R56W	NM_015987	NP_057071	Q9NRV9	HEBP1_HUMAN	heme binding protein 1	56					circadian rhythm	extracellular region				breast(1)	1		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		ATTGCTTCCCGTAGAGCCTCA	0.542													0	0	0	0.005524	0	38	105										A	13142262	G	A	13142262	3	1	7	1	0	0	0	0	1	0	0	0	7036	1144	40	2	415	2	HEBP1	12	13142262	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1803078	13142262	120709633	337	1806										
SLCO1B3	28234	broad.mit.edu	37	chr12	21028360	21028360	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaacaaatgatgatagaaatCaaacagctaatttgaccaac	5	7	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:21028360C>G	uc001rek.2	+	8	1045	c.919C>G	c.(919-921)CAA>GAA	p.Q307E	SLCO1B3_uc001rel.2_Missense_Mutation_p.Q307E|SLCO1B3_uc010sil.1_Missense_Mutation_p.Q307E|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.Q132E	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	307	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGATAGAAATCAAACAGCTAA	0.303													0	0	0	0.004007	0	15	58										G	21028360	C	G	21028360	3	3	7	1	0	0	0	0	1	0	0	0	14724	827	29	1	945	1	SLCO1B3	12	21028360	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7886098	21028360	112823535	338	1807										
ERGIC2	51290	broad.mit.edu	37	chr12	29498381	29498381	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttggattcaacttaccctttCtgtcacagaaaactgatggg	8	9	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:29498381C>T	uc001riv.2	-	11	953	c.820G>A	c.(820-822)GAA>AAA	p.E274K	ERGIC2_uc001riw.2_RNA	NM_016570	NP_057654	Q96RQ1	ERGI2_HUMAN	PTX1 protein	274	Lumenal (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				ovary(1)	1	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)	CTTACCCTTTCTGTCACAGAA	0.323													0	0	0	0.010504	0	19	114										T	29498381	C	T	29498381	3	4	7	1	0	0	0	0	1	0	0	0	5224	922	32	1	329	1	ERGIC2	12	29498381	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	8470021	29498381	104353514	339	1808										
KIF21A	55605	broad.mit.edu	37	chr12	39726896	39726896	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acatgggtcttacttgccgaCgaagagccgtaacctgaaat	10	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:39726896C>T	uc001rly.2	-	19	2647	c.2501G>A	c.(2500-2502)CGT>CAT	p.R834H	KIF21A_uc001rlv.2_5'Flank|KIF21A_uc001rlw.2_Missense_Mutation_p.R151H|KIF21A_uc001rlx.2_Missense_Mutation_p.R821H|KIF21A_uc001rlz.2_Missense_Mutation_p.R798H|KIF21A_uc010skl.1_Missense_Mutation_p.R821H	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	834					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TACTTGCCGACGAAGAGCCGT	0.443													0	0	0	0.001168	0	6	96										T	39726896	C	T	39726896	3	4	7	1	0	0	0	0	1	0	0	0	8288	536	19	2	2603	2	KIF21A	12	39726896	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	10228515	39726896	94124999	340	1809										
TMBIM6	7009	broad.mit.edu	37	chr12	50156659	50156667	+	In_Frame_Del	DEL	AAGAAGAAA	AAGAAGAAA	-													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttttctccatttctaggatAagaagaaagagaagaaatga							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:50156659_50156667delAAGAAGAAA	uc001rux.2	+	10	826_834	c.694_702delAAGAAGAAA	c.(694-702)AAGAAGAAAdel	p.KKK232del	TMBIM6_uc010sml.1_3'UTR|TMBIM6_uc001ruy.2_In_Frame_Del_p.KKK290del|TMBIM6_uc001ruz.2_In_Frame_Del_p.KKK232del	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	232_234					apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						TTTCTAGGATAAGAAGAAAGAGAAGAAAT	0.397											OREG0021802	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						8	178	---	---								-	50156667	AAGAAGAAA	-	50156659	7	5	7	1	0	1	0	1	0	0	0	0	15980	363	13	0	906	0	TMBIM6	12	50156659	In_Frame_Del	DEL	AAGAAGAAA	TCGA-BT-A20J-01A-11D-A14W-08	10429763	50156659	83695236	341	1810										
LETMD1	25875	broad.mit.edu	37	chr12	51449628	51449628	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcctttcaggtacctgtttCccaggcaactactgatcagg	8	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:51449628C>T	uc001rxm.2	+	5	540	c.484C>T	c.(484-486)CCC>TCC	p.P162S	LETMD1_uc010smz.1_Missense_Mutation_p.P112S|LETMD1_uc010sna.1_Intron|LETMD1_uc001rxl.2_Missense_Mutation_p.P106S|LETMD1_uc009zlv.2_Intron|LETMD1_uc001rxs.2_Intron|LETMD1_uc009zlw.2_Missense_Mutation_p.P175S|LETMD1_uc001rxn.2_Missense_Mutation_p.P5S|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Missense_Mutation_p.P45S|LETMD1_uc001rxq.2_Intron|LETMD1_uc001rxr.2_Intron|LETMD1_uc001rxt.2_Intron	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	162	Mitochondrial intermembrane (Potential).|LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						GTACCTGTTTCCCAGGCAACT	0.418													0	0	0	0.007291	0	27	59										T	51449628	C	T	51449628	3	4	7	1	0	0	0	0	1	0	0	0	8736	855	30	1	502	1	LETMD1	12	51449628	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1292969	51449628	82402267	342	1811										
PRR13	54458	broad.mit.edu	37	chr12	53839821	53839821	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcctcctcttcctcctcctCttccagcagtgattctgact	4	17	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:53839821C>T	uc001scz.3	+	4	589	c.425C>T	c.(424-426)TCT>TTT	p.S142F	PRR13_uc001scy.3_Missense_Mutation_p.S92F|PCBP2_uc010soh.1_Intron|PRR13_uc001sda.3_Missense_Mutation_p.S142F	NM_018457	NP_060927	Q9NZ81	PRR13_HUMAN	proline rich 13 isoform 1	142	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						TCCTCCTCCTCTTCCAGCAGT	0.512													0	0	0	0.002836	0	32	64										T	53839821	C	T	53839821	3	4	7	1	0	0	0	0	1	0	0	0	12585	913	32	1	435	1	PRR13	12	53839821	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2390193	53839821	80012074	343	1812										
NPFF	8620	broad.mit.edu	37	chr12	53900619	53900619	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaactgggaattcagcccctCtccagcccggggactcagcc	11	16	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:53900619C>G	uc001sdw.1	-	3	447	c.283G>C	c.(283-285)GAG>CAG	p.E95Q		NM_003717	NP_003708	O15130	NPFF_HUMAN	neuropeptide FF-amide peptide preproprotein	95					neuropeptide signaling pathway|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0						TTCAGCCCCTCTCCAGCCCGG	0.552													0	0	0	0.00632	0	25	124										G	53900619	C	G	53900619	3	3	7	1	0	0	0	0	1	0	0	0	10576	922	32	1	62	1	NPFF	12	53900619	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	60798	53900619	79951276	344	1813										
HOXC4	3221	broad.mit.edu	37	chr12	54448006	54448006	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcacagtcgctctgcgagccGgcgcctctctcaggcgcctc	11	18	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:54448006G>A	uc001seu.2	+	3	980	c.300G>A	c.(298-300)CCG>CCA	p.P100P	HOXC4_uc001sex.2_Silent_p.P100P	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	100						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCTGCGAGCCGGCGCCTCTCT	0.731													0	0	0	0.000602	0	5	24										A	54448006	G	A	54448006	2	1	7	1	0	0	0	0	0	0	0	1	7313	1103	39	2		2	HOXC4	12	54448006	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	547387	54448006	79403889	345	1814										
FRS2	10818	broad.mit.edu	37	chr12	69964277	69964277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cttttcttttgaaagtggtcGaaggtgtcaaactggacaag	11	6	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:69964277G>A	uc001suy.2	+	7	743	c.233G>A	c.(232-234)CGA>CAA	p.R78Q	FRS2_uc001suz.2_Missense_Mutation_p.R78Q|FRS2_uc009zrj.2_Missense_Mutation_p.R78Q|FRS2_uc009zrk.2_Missense_Mutation_p.R78Q	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	78	IRS-type PTB.				activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GAAAGTGGTCGAAGGTGTCAA	0.363													0	0	0	0.010729	0	12	41										A	69964277	G	A	69964277	3	1	7	1	0	0	0	0	1	0	0	0	6061	1058	37	1	239	1	FRS2	12	69964277	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	15516271	69964277	63887618	346	1815										
PLXNC1	10154	broad.mit.edu	37	chr12	94691157	94691157	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	catcgagggaagcacaagttCaaagtaaaagaaatgtatct	9	6	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:94691157C>G	uc001tdc.2	+	26	4281	c.4032C>G	c.(4030-4032)TTC>TTG	p.F1344L	PLXNC1_uc010sut.1_Missense_Mutation_p.F391L|PLXNC1_uc009zsv.2_Missense_Mutation_p.F83L	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1344	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						AGCACAAGTTCAAAGTAAAAG	0.448													0	0	0	0.000602	0	5	27										G	94691157	C	G	94691157	3	3	7	1	0	0	0	0	1	0	0	0	12126	825	29	1	4134	1	PLXNC1	12	94691157	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	24726880	94691157	39160738	347	1816										
UTP20	27340	broad.mit.edu	37	chr12	101767492	101767492	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tacttggtaaaatcagcctcGagaaaaaagattggctgttt	9	6	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:101767492G>A	uc001tia.1	+	54	7234	c.7078G>A	c.(7078-7080)GAG>AAG	p.E2360K		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2360					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AATCAGCCTCGAGAAAAAAGA	0.418													0	0	0	0.008291	0	9	57										A	101767492	G	A	101767492	3	1	7	1	0	0	0	0	1	0	0	0	17096	1059	37	1	7292	1	UTP20	12	101767492	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7076335	101767492	32084403	348	1817										
TXNRD1	7296	broad.mit.edu	37	chr12	104725378	104725378	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atggtgcttgtggcctttctGaggagaaagctgtggagaag	16	5	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:104725378G>A	uc010swk.1	+	14	1631	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K	TXNRD1_uc010swl.1_Missense_Mutation_p.E387K|TXNRD1_uc010swm.1_Missense_Mutation_p.E439K|TXNRD1_uc010swn.1_Missense_Mutation_p.E387K|TXNRD1_uc010swo.1_Missense_Mutation_p.E387K|TXNRD1_uc010swp.1_Missense_Mutation_p.E349K|TXNRD1_uc010swq.1_Missense_Mutation_p.E437K|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.E453K	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	537					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TGGCCTTTCTGAGGAGAAAGC	0.338													0	0	0	0.00308	0	5	23										A	104725378	G	A	104725378	3	1	7	1	0	0	0	0	1	0	0	0	16804	1291	45	1	1677	1	TXNRD1	12	104725378	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2957886	104725378	29126517	349	1818										
APPL2	55198	broad.mit.edu	37	chr12	105600843	105600843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggagggactcccctacctgtCcatgggcaaagcctatcatg	11	13	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:105600843C>T	uc001tlf.1	-	8	835	c.617G>A	c.(616-618)GGA>GAA	p.G206E	APPL2_uc010swt.1_Missense_Mutation_p.G163E|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.G212E|APPL2_uc009zuq.2_Missense_Mutation_p.G163E	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	206	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCCTACCTGTCCATGGGCAAA	0.557													0	0	0	0.00245	0	14	49										T	105600843	C	T	105600843	3	4	7	1	0	0	0	0	1	0	0	0	818	855	30	1	1433	1	APPL2	12	105600843	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	875465	105600843	28251052	350	1819										
APPL2	55198	broad.mit.edu	37	chr12	105601808	105601808	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgccattgagaggtcatgctCtaaaaataaacagacatctg	8	8	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:105601808C>G	uc001tlf.1	-	7	634	c.416_splice	c.e7-1	p.E139_splice	APPL2_uc010swt.1_Splice_Site_p.E96_splice|APPL2_uc001tlg.1_Splice_Site|APPL2_uc010swu.1_Missense_Mutation_p.E145Q|APPL2_uc009zuq.2_Splice_Site_p.E96_splice	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH						cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						AGGTCATGCTCTAAAAATAAA	0.443													0	0	0	0.005443	0	27	153										G	105601808	C	G	105601808	5	3	7	1	0	0	0	0	0	0	1	0	818	927	32	1	1639	1	APPL2	12	105601808	Splice_Site	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	965	105601808	28250087	351	1820										
TCP11L2	255394	broad.mit.edu	37	chr12	106740129	106740129	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccctcaaaaatgcatgcctCctatgccaggaggcctagct	9	14	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:106740129C>T	uc001tln.2	+	10	1555	c.1381C>T	c.(1381-1383)CCT>TCT	p.P461S		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	461										ovary(3)	3						ATGCATGCCTCCTATGCCAGG	0.418													0	0	0	0.006214	0	8	49										T	106740129	C	T	106740129	3	4	7	1	0	0	0	0	1	0	0	0	15712	855	30	1	1415	1	TCP11L2	12	106740129	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1138321	106740129	27111766	352	1821										
RIC8B	55188	broad.mit.edu	37	chr12	107208957	107208957	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctttagcatcaagtggaccGatgagtatgaatcggccata	10	9	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:107208957G>A	uc001tlx.2	+	3	741	c.616G>A	c.(616-618)GAT>AAT	p.D206N	RIC8B_uc001tlw.2_Missense_Mutation_p.D206N|RIC8B_uc001tly.2_Missense_Mutation_p.D166N|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	206					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						CAAGTGGACCGATGAGTATGA	0.507													0	0	0	0.006122	0	18	88										A	107208957	G	A	107208957	3	1	7	1	0	0	0	0	1	0	0	0	13356	1058	37	1	626	1	RIC8B	12	107208957	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	468828	107208957	26642938	353	1822										
ACAD10	80724	broad.mit.edu	37	chr12	112194215	112194215	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccgagccctgcgctttgccGacggccctgacgaggtgcac	13	17	0	1	rs142030532	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:112194215G>A	uc001tsq.2	+	21	3318	c.3118G>A	c.(3118-3120)GAC>AAC	p.D1040N	ACAD10_uc009zvx.2_Missense_Mutation_p.D1071N|ACAD10_uc001tss.1_Intron	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	1040							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GCGCTTTGCCGACGGCCCTGA	0.647													0	0	0	0.004482	0	9	32										A	112194215	G	A	112194215	3	1	7	1	0	0	0	0	1	0	0	0	108	1058	37	1	3293	1	ACAD10	12	112194215	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4985258	112194215	21657680	354	1823										
NAA25	80018	broad.mit.edu	37	chr12	112477060	112477060	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgctggtttcttttttcttCtttttctttttctgtaaatt	4	6	5	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:112477060C>A	uc001ttm.2	-	22	2642	c.2622G>T	c.(2620-2622)AAG>AAT	p.K874N	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.K846N|NAA25_uc009zwa.1_Missense_Mutation_p.K852N	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	874	Poly-Lys.					cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CTTTTTTCTTCTTTTTCTTTT	0.343													1	0	1.5842e-08	0.001855	1.67396e-08	13	47										A	112477060	C	A	112477060	3	1	7	1	0	0	0	0	1	0	0	0	10121	912	32	3	308	3	NAA25	12	112477060	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	282845	112477060	21374835	355	1824										
C12orf51	283450	broad.mit.edu	37	chr12	112609068	112609068	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caggctctcgatgggcacgtCtgagggcgcaggagcagtca	16	11	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:112609068C>T	uc009zwc.2	-	61	10538	c.10520_splice	c.e61-1	p.N3507_splice		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATGGGCACGTCTGAGGGCGCA	0.622													0	0	0	0.001168	0	5	9										T	112609068	C	T	112609068	5	4	7	1	0	0	0	0	0	0	1	0	1696	927	32	1	1507	1	C12orf51	12	112609068	Splice_Site	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	132008	112609068	21242827	356	1825										
MED13L	23389	broad.mit.edu	37	chr12	116420239	116420239	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtaaattatccagcatttCtgtgtagcagcgcatcaagc	9	9	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:116420239C>T	uc001tvw.2	-	22	5180	c.5125G>A	c.(5125-5127)GAA>AAA	p.E1709K		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1709					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCCAGCATTTCTGTGTAGCAG	0.393													0	0	0	0.003954	0	23	99										T	116420239	C	T	116420239	3	4	7	1	0	0	0	0	1	0	0	0	9431	922	32	1	1547	1	MED13L	12	116420239	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3811171	116420239	17431656	357	1826										
WDR66	144406	broad.mit.edu	37	chr12	122398579	122398579	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcaagacttcgctctcatcGcaaaagcattcgaagtctcc	7	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:122398579G>A	uc009zxk.2	+	14	2364	c.2222G>A	c.(2221-2223)CGC>CAC	p.R741H		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	741							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CGCTCTCATCGCAAAAGCATT	0.488													0	0	0	0.004482	0	8	100										A	122398579	G	A	122398579	3	1	7	1	0	0	0	0	1	0	0	0	17314	1087	38	2	2272	2	WDR66	12	122398579	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	5978340	122398579	11453316	358	1827										
GTF2H3	2967	broad.mit.edu	37	chr12	124132646	124132646	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagcaaatgaagttattgttGaagagattaaagatctaatg	9	3	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:124132646G>A	uc001ufo.1	+	4	363	c.337G>A	c.(337-339)GAA>AAA	p.E113K	GTF2H3_uc010tau.1_Missense_Mutation_p.E72K	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	113					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		AGTTATTGTTGAAGAGATTAA	0.353								NER					0	0	0	0.001855	0	13	69										A	124132646	G	A	124132646	3	1	7	1	0	0	0	0	1	0	0	0	6864	1291	45	1	351	1	GTF2H3	12	124132646	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1734067	124132646	9719249	359	1828										
ULK1	8408	broad.mit.edu	37	chr12	132380333	132380333	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggtttctgtcctaggaactGaaacatgaaaacatcgtggc	11	8	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:132380333G>A	uc001uje.2	+	3	478	c.210G>A	c.(208-210)CTG>CTA	p.L70L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	70	Protein kinase.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCTAGGAACTGAAACATGAAA	0.632													0	0	0	0.006214	0	9	59										A	132380333	G	A	132380333	2	1	7	1	0	0	0	0	0	0	0	1	16972	1277	45	1		1	ULK1	12	132380333	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8247687	132380333	1471562	360	1829										
ANKLE2	23141	broad.mit.edu	37	chr12	133327431	133327431	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttattttcataaacatagatCctttctgggtaagaaaagta	6	5	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr12:133327431C>G	uc001ukx.2	-	3	712	c.645G>C	c.(643-645)AGG>AGC	p.R215S	ANKLE2_uc001uky.3_Missense_Mutation_p.R153S	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	215						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		AAACATAGATCCTTTCTGGGT	0.423													0	0	0	0.004482	0	8	74										G	133327431	C	G	133327431	3	3	7	1	0	0	0	0	1	0	0	0	633	854	30	1	2215	1	ANKLE2	12	133327431	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	947098	133327431	524464	361	1830										
LATS2	26524	broad.mit.edu	37	chr13	21562346	21562346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtactgctccgacttgctgcGcagcagcaggtgcttcgggt	14	12	0	0	rs147172274	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:21562346G>A	uc009zzs.2	-	4	1938	c.1573C>T	c.(1573-1575)CGC>TGC	p.R525C	LATS2_uc001unr.3_Missense_Mutation_p.R525C	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	525					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GACTTGCTGCGCAGCAGCAGG	0.726													0	0	0	0.00308	0	8	47										A	21562346	G	A	21562346	3	1	7	1	0	0	0	0	1	0	0	0	8647	1087	38	2	1713	2	LATS2	13	21562346	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		21562346	93607532	362	1831										
CENPJ	55835	broad.mit.edu	37	chr13	25457361	25457361	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taccctccttgtccttaactCttatccgaccggatctgtac	5	15	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:25457361C>G	uc001upt.3	-	17	4224	c.3971G>C	c.(3970-3972)AGA>ACA	p.R1324T	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	1324					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GTCCTTAACTCTTATCCGACC	0.428													0	0	0	0.004672	0	3	150										G	25457361	C	G	25457361	3	3	7	1	0	0	0	0	1	0	0	0	3234	913	32	1	49	1	CENPJ	13	25457361	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3895015	25457361	89712517	363	1832										
TRPC4	7223	broad.mit.edu	37	chr13	38225536	38225536	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtaggcagagtacctccttCttcaaaataactcatccaaa	5	11	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:38225536C>T	uc001uws.2	-	8	2180	c.1945G>A	c.(1945-1947)GAA>AAA	p.E649K	TRPC4_uc010abv.2_Missense_Mutation_p.E229K|TRPC4_uc001uwt.2_Missense_Mutation_p.E649K|TRPC4_uc010tey.1_Missense_Mutation_p.E649K|TRPC4_uc010abw.2_Missense_Mutation_p.E476K|TRPC4_uc010abx.2_Missense_Mutation_p.E649K|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	649	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTACCTCCTTCTTCAAAATAA	0.428													0	0	0	0.008871	0	18	49										T	38225536	C	T	38225536	3	4	7	1	0	0	0	0	1	0	0	0	16577	922	32	1	1019	1	TRPC4	13	38225536	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	12768175	38225536	76944342	364	1833										
ELF1	1997	broad.mit.edu	37	chr13	41507794	41507794	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtgggtgagcaaccagctGtgaactgcgaggagaaaagg	17	6	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:41507794G>A	uc001uxs.2	-	9	2000	c.1627C>T	c.(1627-1629)CAG>TAG	p.Q543*	ELF1_uc010tfc.1_Nonsense_Mutation_p.Q519*|ELF1_uc010acd.2_Nonsense_Mutation_p.Q436*	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	543					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		GCAACCAGCTGTGAACTGCGA	0.453													0	0	0	0.008291	0	10	99										A	41507794	G	A	41507794	4	1	7	1	0	0	0	0	0	1	0	0	5053	1386	48	2	236	2	ELF1	13	41507794	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3282258	41507794	73662084	365	1834										
DNAJC15	29103	broad.mit.edu	37	chr13	43643082	43643082	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttaggtcgctacgcatttcgGatctggaaacctctagaaca	9	10	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:43643082G>A	uc001uyy.2	+	3	578	c.177G>A	c.(175-177)CGG>CGA	p.R59R		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	59						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		ACGCATTTCGGATCTGGAAAC	0.333													0	0	0	0.009096	0	3	35										A	43643082	G	A	43643082	2	1	7	1	0	0	0	0	0	0	0	1	4634	1161	41	1		1	DNAJC15	13	43643082	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2135288	43643082	71526796	366	1835										
TSC22D1	8848	broad.mit.edu	37	chr13	45147767	45147767	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	taactgcaggcaactgctgtGaaacaattccttgagctact	8	10	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:45147767G>C	uc001uzn.3	-	1	2935	c.2444C>G	c.(2443-2445)TCA>TGA	p.S815*	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	815	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CAACTGCTGTGAAACAATTCC	0.468													0	0	0	0.00499	0	18	101										C	45147767	G	C	45147767	4	2	7	1	0	0	0	0	0	1	0	0	16604	1294	45	1	918	1	TSC22D1	13	45147767	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1504685	45147767	70022111	367	1836										
ZC3H13	23091	broad.mit.edu	37	chr13	46559516	46559516	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcgagactcatttctggactCattccttatttccgtacgag	7	11	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:46559516C>G	uc010tfw.1	-	9	1642	c.1636G>C	c.(1636-1638)GAG>CAG	p.E546Q	ZC3H13_uc001vas.1_Missense_Mutation_p.E546Q|ZC3H13_uc001vat.1_Missense_Mutation_p.E546Q	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	546	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TTTCTGGACTCATTCCTTATT	0.438													0	0	0	0.001168	0	6	76										G	46559516	C	G	46559516	3	3	7	1	0	0	0	0	1	0	0	0	17562	835	29	1	3090	1	ZC3H13	13	46559516	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1411749	46559516	68610362	368	1837										
CPB2	1361	broad.mit.edu	37	chr13	46656653	46656653	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtcgttggaaatctgctgttGaataagatcttccacatctg	9	8	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:46656653G>A	uc001vaw.2	-	4	374	c.307C>T	c.(307-309)CAA>TAA	p.Q103*	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Nonsense_Mutation_p.Q103*	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	103					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		ATCTGCTGTTGAATAAGATCT	0.483													0	0	0	0.003954	0	23	63										A	46656653	G	A	46656653	4	1	7	1	0	0	0	0	0	1	0	0	3797	1299	45	1	996	1	CPB2	13	46656653	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	97137	46656653	68513225	369	1838										
DHRS12	79758	broad.mit.edu	37	chr13	52373793	52373793	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaagtctttacatgcagattCatagccactcctagaaagag	7	9	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:52373793C>T	uc001vfq.2	-	2	115	c.67G>A	c.(67-69)GAA>AAA	p.E23K	DHRS12_uc001vfr.1_Missense_Mutation_p.M1I|DHRS12_uc001vfs.1_Missense_Mutation_p.M1I			A0PJE2	DHR12_HUMAN	RecName: Full=Dehydrogenase/reductase SDR family member 12;          EC=1.1.-.-;	23							binding|oxidoreductase activity				0		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)		CATGCAGATTCATAGCCACTC	0.493													0	0	0	0.00361	0	78	104										T	52373793	C	T	52373793	3	4	7	1	0	0	0	0	1	0	0	0	4488	826	29	1	1014	1	DHRS12	13	52373793	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5717140	52373793	62796085	370	1839										
CKAP2	26586	broad.mit.edu	37	chr13	53036693	53036693	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttttctgaatgcctgaacttGattaatgaggtagagtcttt	9	5	2	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:53036693G>C	uc001vgv.2	+	5	1496	c.1299G>C	c.(1297-1299)TTG>TTC	p.L433F	CKAP2_uc001vgt.2_Missense_Mutation_p.L432F|CKAP2_uc001vgu.2_Missense_Mutation_p.L432F|CKAP2_uc010tha.1_Missense_Mutation_p.L384F	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	433					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		GCCTGAACTTGATTAATGAGG	0.229													0	0	0	0.009096	0	4	48										C	53036693	G	C	53036693	3	2	7	1	0	0	0	0	1	0	0	0	3442	1281	45	1	1317	1	CKAP2	13	53036693	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	662900	53036693	62133185	371	1840										
DIAPH3	81624	broad.mit.edu	37	chr13	60348372	60348372	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgagacattggactgagactCtgccgaacatctgttaaaaa	9	8	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:60348372C>T	uc001vht.2	-	27	3489	c.3270G>A	c.(3268-3270)CAG>CAA	p.Q1090Q	DIAPH3_uc001vhu.2_Silent_p.Q827Q	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	1090					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GACTGAGACTCTGCCGAACAT	0.323													0	0	0	0.010504	0	19	20										T	60348372	C	T	60348372	2	4	7	1	0	0	0	0	0	0	0	1	4520	912	32	1		1	DIAPH3	13	60348372	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7311679	60348372	54821506	372	1841										
TBC1D4	9882	broad.mit.edu	37	chr13	75869130	75869130	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatagtcatgaaggagcctgGacagctggtacatttgaatc	12	7	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:75869130G>C	uc001vjl.1	-	18	3523	c.3176C>G	c.(3175-3177)TCC>TGC	p.S1059C	TBC1D4_uc010tht.1_Missense_Mutation_p.S269C|TBC1D4_uc010thu.1_Missense_Mutation_p.S216C|TBC1D4_uc010aer.2_Missense_Mutation_p.S1051C|TBC1D4_uc010aes.2_Missense_Mutation_p.S996C	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1059	Rab-GAP TBC.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AAGGAGCCTGGACAGCTGGTA	0.358													0	0	0	0.00245	0	13	66										C	75869130	G	C	75869130	3	2	7	1	0	0	0	0	1	0	0	0	15619	1174	41	1	736	1	TBC1D4	13	75869130	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	15520758	75869130	39300748	373	1842										
GPR180	160897	broad.mit.edu	37	chr13	95273330	95273330	+	Splice_Site	DEL	A	A	-													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gttggttttcatgtcccattAgtttttgacatcgcttccca							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:95273330delA	uc001vly.2	+	6	815	c.737_splice	c.e6-2	p.F246_splice	GPR180_uc001vlz.2_Splice_Site_p.F145_splice|GPR180_uc010afi.2_Splice_Site_p.F7_splice	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor							integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					ATGTCCCATTAGTTTTTGACA	0.333																		42	54	---	---								-	95273330	A	-	95273330	8	5	7	1	0	1	0	1	0	0	1	0	6676	434	15	0	757	0	GPR180	13	95273330	Splice_Site	DEL	A	TCGA-BT-A20J-01A-11D-A14W-08	19404200	95273330	19896548	374	1843										
RNF113B	140432	broad.mit.edu	37	chr13	98829136	98829136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cggcgtatggtgctccttctCggtgtcctgctcgaagtcag	13	12	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr13:98829136C>T	uc001vnk.2	-	1	386	c.355G>A	c.(355-357)GAG>AAG	p.E119K	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	119							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			TGCTCCTTCTCGGTGTCCTGC	0.667													0	0	0	0.002299	0	22	35										T	98829136	C	T	98829136	3	4	7	1	0	0	0	0	1	0	0	0	13428	893	31	1	621	1	RNF113B	13	98829136	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3555806	98829136	16340742	375	1844										
SUPT16H	11198	broad.mit.edu	37	chr14	21828595	21828597	+	In_Frame_Del	DEL	AAT	AAT	-													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgaggtgaaagtgcaagacAataatcatttctccatcaca							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:21828595_21828597delAAT	uc001wao.2	-	18	2491_2493	c.2152_2154delATT	c.(2152-2154)ATTdel	p.I718del	SUPT16H_uc001wan.2_5'Flank	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	718					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		AGTGCAAGACAATAATCATTTCT	0.271																		17	98	---	---								-	21828597	AAT	-	21828595	7	5	7	1	0	1	0	1	0	0	0	0	15393	126	5	0	1025	0	SUPT16H	14	21828595	In_Frame_Del	DEL	AAT	TCGA-BT-A20J-01A-11D-A14W-08		21828595	85520945	376	1845										
OR4E2	26686	broad.mit.edu	37	chr14	22133602	22133602	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aactgcatcacacagctcttCttcctacatctctttgcctg	4	15	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:22133602C>T	uc010tmd.1	+	1	306	c.306C>T	c.(304-306)TTC>TTT	p.F102F		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CACAGCTCTTCTTCCTACATC	0.463													0	0	0	0.00361	0	81	130										T	22133602	C	T	22133602	2	4	7	1	0	0	0	0	0	0	0	1	11060	912	32	1		1	OR4E2	14	22133602	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	305007	22133602	85215938	377	1846										
MMP14	4323	broad.mit.edu	37	chr14	23312531	23312531	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tggggctcgagcattccagtGacccctcggccatcatggca	12	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:23312531G>T	uc001whc.2	+	5	988	c.754G>T	c.(754-756)GAC>TAC	p.D252Y		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	252	Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		GCATTCCAGTGACCCCTCGGC	0.582													1	0	3.45872e-05	0.004007	3.57798e-05	14	40										T	23312531	G	T	23312531	3	4	7	1	0	0	0	0	1	0	0	0	9653	1290	45	3	772	3	MMP14	14	23312531	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1178929	23312531	84037009	378	1847										
LRP10	26020	broad.mit.edu	37	chr14	23346713	23346713	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggtgtgggtagctgaggcaGaggatgagccactgcttacc	17	8	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:23346713G>A	uc001whd.2	+	7	2672	c.2119G>A	c.(2119-2121)GAG>AAG	p.E707K	LRP10_uc001whe.2_Intron	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	707	Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		AGCTGAGGCAGAGGATGAGCC	0.627													0	0	0	0.00308	0	7	7										A	23346713	G	A	23346713	3	1	7	1	0	0	0	0	1	0	0	0	8952	943	33	1	2145	1	LRP10	14	23346713	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	34182	23346713	84002827	379	1848										
PSME1	5720	broad.mit.edu	37	chr14	24607692	24607692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcttcccacagggtgattatCggcagctggtgcacgagctg	14	11	0	1	rs144591736	by1000genomes	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:24607692C>T	uc001wmg.2	+	10	686	c.592C>T	c.(592-594)CGG>TGG	p.R198W	PSME1_uc001wmh.2_Missense_Mutation_p.R198W	NM_006263	NP_006254	Q06323	PSME1_HUMAN	proteasome activator subunit 1 isoform 1	198					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00831)		GGGTGATTATCGGCAGCTGGT	0.607													0	0	0	0.004656	0	27	105										T	24607692	C	T	24607692	3	4	7	1	0	0	0	0	1	0	0	0	12706	875	31	1	630	1	PSME1	14	24607692	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1260979	24607692	82741848	380	1849										
ARHGAP5	394	broad.mit.edu	37	chr14	32560018	32560018	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtacgctcaaaagcagatgAatattatccagagcatactt	7	8	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:32560018A>G	uc001wrl.2	+	2	382	c.143A>G	c.(142-144)GAA>GGA	p.E48G	ARHGAP5_uc001wrm.2_Missense_Mutation_p.E48G|ARHGAP5_uc001wrn.2_Missense_Mutation_p.E48G|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	48					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AAAGCAGATGAATATTATCCA	0.383													0	0	0	0.002299	0	21	40										G	32560018	A	G	32560018	3	3	7	1	0	0	0	0	1	0	0	0	886	246	9	5	145	5	ARHGAP5	14	32560018	Missense_Mutation	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	7952326	32560018	74789522	381	1850										
ARHGAP5	394	broad.mit.edu	37	chr14	32560228	32560228	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttgcaaccatatataaaacGtgcagctgcatctaaattgc	6	9	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:32560228G>A	uc001wrl.2	+	2	592	c.353G>A	c.(352-354)CGT>CAT	p.R118H	ARHGAP5_uc001wrm.2_Missense_Mutation_p.R118H|ARHGAP5_uc001wrn.2_Missense_Mutation_p.R118H|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	118					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TATATAAAACGTGCAGCTGCA	0.388													0	0	0	0.006214	0	9	37										A	32560228	G	A	32560228	3	1	7	1	0	0	0	0	1	0	0	0	886	1145	40	2	355	2	ARHGAP5	14	32560228	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	210	32560228	74789312	382	1851										
LRFN5	145581	broad.mit.edu	37	chr14	42355925	42355925	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtcagattttgtctcctaatCttgcaaccctttgtgccaag	7	11	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:42355925C>G	uc001wvm.2	+	3	1295	c.97C>G	c.(97-99)CTT>GTT	p.L33V	LRFN5_uc010ana.2_Missense_Mutation_p.L33V	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	33	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTCTCCTAATCTTGCAACCCT	0.383										HNSCC(30;0.082)			0	0	0	0.001984	0	7	34										G	42355925	C	G	42355925	3	3	7	1	0	0	0	0	1	0	0	0	8941	913	32	1	99	1	LRFN5	14	42355925	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	9795697	42355925	64993615	383	1852										
OTX2	5015	broad.mit.edu	37	chr14	57270957	57270957	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtgccacctcctctcgcatGaagatgtctgggtaccgggt	12	12	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:57270957G>A	uc001xcp.2	-	2	369	c.198C>T	c.(196-198)TTC>TTT	p.F66F	OTX2_uc010aou.2_Silent_p.F66F|OTX2_uc001xcq.2_Silent_p.F74F	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	66	Homeobox.				axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CCTCTCGCATGAAGATGTCTG	0.597													0	0	0	0.012319	0	21	31										A	57270957	G	A	57270957	2	1	7	1	0	0	0	0	0	0	0	1	11321	1281	45	1		1	OTX2	14	57270957	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	14915032	57270957	50078583	384	1853										
SYNE2	23224	broad.mit.edu	37	chr14	64519306	64519306	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agaaattgacagtggaatctCaacacatcttcaggagctaa	8	8	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:64519306C>T	uc001xgm.2	+	48	8905	c.8675C>T	c.(8674-8676)TCA>TTA	p.S2892L	SYNE2_uc001xgl.2_Missense_Mutation_p.S2892L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2892	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTGGAATCTCAACACATCTT	0.413													0	0	0	0.012319	0	21	17										T	64519306	C	T	64519306	3	4	7	1	0	0	0	0	1	0	0	0	15443	838	29	1	8861	1	SYNE2	14	64519306	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7248349	64519306	42830234	385	1854										
C14orf43	91748	broad.mit.edu	37	chr14	74196502	74196502	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtagctcaaagctccgctCagaggggtggtcagctaggc	15	10	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:74196502C>T	uc001xot.2	-	4	2719	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K	C14orf43_uc001xos.2_5'Flank|C14orf43_uc001xou.2_Missense_Mutation_p.E646K|C14orf43_uc010tud.1_Missense_Mutation_p.E646K|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		AAGCTCCGCTCAGAGGGGTGG	0.622													0	0	0	0.001855	0	14	19										T	74196502	C	T	74196502	3	4	7	1	0	0	0	0	1	0	0	0	1774	835	29	1	1237	1	C14orf43	14	74196502	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	9677196	74196502	33153038	386	1855										
C14orf43	91748	broad.mit.edu	37	chr14	74196685	74196685	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caacttgacattcatgtcctCtgcctggagaaggaaagaaa	9	9	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:74196685C>G	uc001xot.2	-	4	2536	c.1753G>C	c.(1753-1755)GAG>CAG	p.E585Q	C14orf43_uc001xos.2_5'Flank|C14orf43_uc001xou.2_Missense_Mutation_p.E585Q|C14orf43_uc010tud.1_Missense_Mutation_p.E585Q|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		TTCATGTCCTCTGCCTGGAGA	0.567													0	0	0	0.006214	0	10	26										G	74196685	C	G	74196685	3	3	7	1	0	0	0	0	1	0	0	0	1774	922	32	1	1420	1	C14orf43	14	74196685	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	183	74196685	33152855	387	1856										
C14orf43	91748	broad.mit.edu	37	chr14	74205546	74205546	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caggatggggctgccccaggGagccaggtggcggctgctgc	19	12	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:74205546G>C	uc001xot.2	-	2	1949	c.1166C>G	c.(1165-1167)TCC>TGC	p.S389C	C14orf43_uc001xou.2_Missense_Mutation_p.S389C|C14orf43_uc010tud.1_Missense_Mutation_p.S389C|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	389	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		CTGCCCCAGGGAGCCAGGTGG	0.677													0	0	0	0.001984	0	6	11										C	74205546	G	C	74205546	3	2	7	1	0	0	0	0	1	0	0	0	1774	1174	41	1	2015	1	C14orf43	14	74205546	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8861	74205546	33143994	388	1857										
RPS6KA5	9252	broad.mit.edu	37	chr14	91372604	91372604	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtctttcgctaaagcactCatttcttggggatatggagg	12	7	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:91372604C>G	uc001xys.2	-	8	1061	c.846G>C	c.(844-846)ATG>ATC	p.M282I	RPS6KA5_uc010twi.1_Missense_Mutation_p.M203I|RPS6KA5_uc001xyt.2_Missense_Mutation_p.M282I|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	282	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CTAAAGCACTCATTTCTTGGG	0.383													0	0	0	0.009096	0	4	55										G	91372604	C	G	91372604	3	3	7	1	0	0	0	0	1	0	0	0	13654	826	29	1	1608	1	RPS6KA5	14	91372604	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	17167058	91372604	15976936	389	1858										
UBR7	55148	broad.mit.edu	37	chr14	93693381	93693381	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgcagtattactgcagctaGagtggagtatgaagctttct	11	6	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:93693381G>C	uc001ybm.3	+	11	1514	c.1278G>C	c.(1276-1278)TAG>TAC	p.*426Y	UBR7_uc001ybn.3_Nonstop_Mutation_p.*350Y|UBR7_uc010auq.2_Nonstop_Mutation_p.*275Y	NM_175748	NP_786924	Q8N806	UBR7_HUMAN	ubiquitin protein ligase E3 component n-recognin	426							ubiquitin-protein ligase activity|zinc ion binding				0						ACTGCAGCTAGAGTGGAGTAT	0.428													0	0	0	0.006214	0	10	35										C	93693381	G	C	93693381	4	2	7	1	0	0	0	0	0	0	0	0	16903	937	33	1	1320	1	UBR7	14	93693381	Nonstop_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2320777	93693381	13656159	390	1859										
DDX24	57062	broad.mit.edu	37	chr14	94526925	94526925	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcagcaaaatggcctttctCaaccatccggtcagcctcat	6	15	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:94526925C>T	uc001ycj.2	-	5	1531	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K	DDX24_uc010twq.1_Missense_Mutation_p.E435K|DDX24_uc010twr.1_Missense_Mutation_p.E228K	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	478	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TGGCCTTTCTCAACCATCCGG	0.493													0	0	0	0.001855	0	14	49										T	94526925	C	T	94526925	3	4	7	1	0	0	0	0	1	0	0	0	4351	835	29	1	1167	1	DDX24	14	94526925	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	833544	94526925	12822615	391	1860										
SERPINA9	327657	broad.mit.edu	37	chr14	94929550	94929550	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagtaagaggggccatccttCgatcggactatgaacttggt	12	8	0	2	rs139618805	by1000genomes	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:94929550C>T	uc001ydf.2	-	5	1349	c.1188G>A	c.(1186-1188)TCG>TCA	p.S396S	SERPINA9_uc001yde.2_Silent_p.S296S|SERPINA9_uc010avc.2_Silent_p.S247S|SERPINA9_uc001ydg.2_Silent_p.S360S	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	378					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GGCCATCCTTCGATCGGACTA	0.498													0	0	0	0.010504	0	20	41										T	94929550	C	T	94929550	2	4	7	1	0	0	0	0	0	0	0	1	14095	871	31	1		1	SERPINA9	14	94929550	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	402625	94929550	12419990	392	1861										
SERPINA12	145264	broad.mit.edu	37	chr14	94956013	94956013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggtgagatcaccatgttcctCaaagattttggagacaccta	9	9	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr14:94956013C>G	uc001ydj.2	-	5	1793	c.997G>C	c.(997-999)GAG>CAG	p.E333Q		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	333					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		CCATGTTCCTCAAAGATTTTG	0.562													0	0	0	0.001368	0	12	24										G	94956013	C	G	94956013	3	3	7	1	0	0	0	0	1	0	0	0	14089	835	29	1	255	1	SERPINA12	14	94956013	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	26463	94956013	12393527	393	1862										
GJD2	57369	broad.mit.edu	37	chr15	35044759	35044759	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caggtccttgttacgaatctCatagattgactttctcttgg	8	9	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:35044759C>T	uc001zis.1	-	2	886	c.886G>A	c.(886-888)GAG>AAG	p.E296K	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	296	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		TTACGAATCTCATAGATTGAC	0.527													0	0	0	0.001984	0	6	36										T	35044759	C	T	35044759	3	4	7	1	0	0	0	0	1	0	0	0	6417	835	29	1	83	1	GJD2	15	35044759	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08		35044759	67486633	394	1863										
MEIS2	4212	broad.mit.edu	37	chr15	37390256	37390256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	attggggtgcggggcgtgcgCgccgtagtgctgtgtggcgt	21	8	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:37390256C>T	uc001zjr.2	-	2	1194	c.157G>A	c.(157-159)GCG>ACG	p.A53T	MEIS2_uc001zjl.2_Missense_Mutation_p.A40T|MEIS2_uc010ucj.1_Missense_Mutation_p.A40T|MEIS2_uc001zjm.2_5'UTR|MEIS2_uc001zjn.2_5'UTR|MEIS2_uc001zjo.2_Missense_Mutation_p.A53T|MEIS2_uc001zjp.2_Missense_Mutation_p.A53T|MEIS2_uc001zjs.2_Missense_Mutation_p.A53T|MEIS2_uc001zju.2_Missense_Mutation_p.A40T|MEIS2_uc001zjt.2_Missense_Mutation_p.A53T	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	53					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		GGGGCGTGCGCGCCGTAGTGC	0.667													0	0	0	0.008291	0	8	43										T	37390256	C	T	37390256	3	4	7	1	0	0	0	0	1	0	0	0	9468	768	27	2	1383	2	MEIS2	15	37390256	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2345497	37390256	65141136	395	1864										
MAP1A	4130	broad.mit.edu	37	chr15	43817277	43817277	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcactttctctgtcagaagaGagtcccagcaaggagacctc	9	12	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:43817277G>C	uc001zrt.2	+	4	4073	c.3606G>C	c.(3604-3606)GAG>GAC	p.E1202D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1202						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGTCAGAAGAGAGTCCCAGCA	0.537													0	0	0	0.003163	0	15	52										C	43817277	G	C	43817277	3	2	7	1	0	0	0	0	1	0	0	0	9227	933	33	1	3608	1	MAP1A	15	43817277	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6427021	43817277	58714115	396	1865										
CASC4	113201	broad.mit.edu	37	chr15	44624216	44624216	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggacagcagatgaaggaattGagagcacagcatgaagaaaa	13	5	0	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:44624216G>C	uc001zto.1	+	4	815	c.516G>C	c.(514-516)TTG>TTC	p.L172F	CASC4_uc001ztp.2_Missense_Mutation_p.L172F|CASC4_uc001ztq.2_Missense_Mutation_p.L172F|CASC4_uc010bdu.1_Intron	NM_138423	NP_612432	Q6P4E1	CASC4_HUMAN	cancer susceptibility candidate 4 isoform a	172	Lumenal (Potential).|Potential.					integral to membrane				ovary(1)	1		all_cancers(109;1.69e-13)|all_epithelial(112;3.94e-11)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.027)		all cancers(107;2.91e-20)|GBM - Glioblastoma multiforme(94;1.57e-06)|COAD - Colon adenocarcinoma(120;0.217)|Colorectal(105;0.237)		TGAAGGAATTGAGAGCACAGC	0.269													0	0	0	0.00308	0	4	29										C	44624216	G	C	44624216	3	2	7	1	0	0	0	0	1	0	0	0	2662	1281	45	1	530	1	CASC4	15	44624216	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	806939	44624216	57907176	397	1866										
RPL4	6124	broad.mit.edu	37	chr15	66793735	66793735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggatgtttctgaaggccttGatgataccattatcctcatt	9	8	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:66793735G>C	uc002apv.2	-	6	710	c.654C>G	c.(652-654)ATC>ATG	p.I218M	RPL4_uc010bhr.2_Missense_Mutation_p.I124M|RPL4_uc002apw.2_Missense_Mutation_p.I124M|RPL4_uc002apx.2_Missense_Mutation_p.I124M|RPL4_uc010ujq.1_Missense_Mutation_p.I218M|SNORD18C_uc010bhs.1_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	218					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TGAAGGCCTTGATGATACCAT	0.443													0	0	0	0.005443	0	26	89										C	66793735	G	C	66793735	3	2	7	1	0	0	0	0	1	0	0	0	13595	1280	45	1	649	1	RPL4	15	66793735	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	22169519	66793735	35737657	398	1867										
LCTL	197021	broad.mit.edu	37	chr15	66853624	66853624	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tagttggccatgctcacattCtgccacccaccgtatttgac	7	14	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:66853624C>G	uc002aqc.2	-	5	642	c.510G>C	c.(508-510)CAG>CAC	p.Q170H	LCTL_uc002aqd.3_5'UTR|LCTL_uc010bhw.2_5'UTR	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	170	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						TGCTCACATTCTGCCACCCAC	0.522													0	0	0	0.012319	0	18	103										G	66853624	C	G	66853624	3	3	7	1	0	0	0	0	1	0	0	0	8694	912	32	1	1229	1	LCTL	15	66853624	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	59889	66853624	35677768	399	1868										
ANPEP	290	broad.mit.edu	37	chr15	90349355	90349355	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcggtgggctccaccagctCagtcttgtcaatgtcggggg	14	12	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:90349355C>G	uc002bop.3	-	2	752	c.460G>C	c.(460-462)GAG>CAG	p.E154Q		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	154	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TCCACCAGCTCAGTCTTGTCA	0.617													0	0	0	0.001855	0	11	47										G	90349355	C	G	90349355	3	3	7	1	0	0	0	0	1	0	0	0	710	835	29	1	2523	1	ANPEP	15	90349355	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	23495731	90349355	12182037	400	1869										
UNC45A	55898	broad.mit.edu	37	chr15	91496469	91496469	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggatgatgagctgctacagCgggcagctgccgggggcttg	18	9	0	2	rs8041417	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr15:91496469C>T	uc002bqg.2	+	19	2846	c.2506C>T	c.(2506-2508)CGG>TGG	p.R836W	UNC45A_uc002bqd.2_Missense_Mutation_p.R821W|UNC45A_uc010uqr.1_Missense_Mutation_p.R228W|UNC45A_uc002bqi.2_Missense_Mutation_p.R114W|RCCD1_uc002bqj.2_5'Flank|RCCD1_uc002bqk.2_5'Flank|RCCD1_uc002bql.2_5'Flank	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	836					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCTGCTACAGCGGGCAGCTGC	0.622													0	0	0	0.005443	0	24	116										T	91496469	C	T	91496469	3	4	7	1	0	0	0	0	1	0	0	0	16985	759	27	2	2580	2	UNC45A	15	91496469	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1147114	91496469	11034923	401	1870										
UNKL	64718	broad.mit.edu	37	chr16	1416391	1416391	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgcttggcgcggagctggaaGatcacctgcagggccagaac	15	11	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:1416391G>A	uc010brn.1	-	9	1041	c.1023C>T	c.(1021-1023)ATC>ATT	p.I341I	UNKL_uc002cln.2_Silent_p.I183I|UNKL_uc002clo.2_Silent_p.I180I|UNKL_uc002clp.2_Silent_p.I133I			Q9H9P5	UNKL_HUMAN	SubName: Full=Putative ubiquitin-protein ligase;          EC=6.3.2.19; Flags: Fragment;	631						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				GGAGCTGGAAGATCACCTGCA	0.697													0	0	0	0.004482	0	9	8										A	1416391	G	A	1416391	2	1	7	1	0	0	0	0	0	0	0	1	16998	932	33	1		1	UNKL	16	1416391	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		1416391	88938362	402	1871										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1817918	1817918	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atctccatccccctgacagaGagtgagtggcctgcacacct	9	15	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:1817918G>C	uc002cmk.2	+	28	3639	c.3519G>C	c.(3517-3519)GAG>GAC	p.E1173D	MAPK8IP3_uc002cml.2_Missense_Mutation_p.E1167D|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.E1174D	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1173					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCCTGACAGAGAGTGAGTGGC	0.657													0	0	0	0.006122	0	16	78										C	1817918	G	C	1817918	3	2	7	1	0	0	0	0	1	0	0	0	9286	956	33	1	3645	1	MAPK8IP3	16	1817918	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	401527	1817918	88536835	403	1872										
ZNF263	10127	broad.mit.edu	37	chr16	3339480	3339480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctgcttcctgaccaggcccGaggggaggtgccctggagtc	16	13	0	1	rs79713839	by1000genomes	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:3339480G>A	uc002cuq.2	+	6	1306	c.974G>A	c.(973-975)CGA>CAA	p.R325Q	ZNF263_uc010uww.1_5'UTR|ZNF263_uc002cur.2_5'UTR	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	325					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						GACCAGGCCCGAGGGGAGGTG	0.597													0	0	0	0.00632	0	26	111										A	3339480	G	A	3339480	3	1	7	1	0	0	0	0	1	0	0	0	17800	1058	37	1	996	1	ZNF263	16	3339480	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1521562	3339480	87015273	404	1873										
NAGPA	51172	broad.mit.edu	37	chr16	5077281	5077281	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccttggagggataggtacctCtggagacgctgcagttgcca	14	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:5077281C>G	uc002cyg.2	-	8	1295	c.1274G>C	c.(1273-1275)AGA>ACA	p.R425T	NAGPA_uc010buc.2_Intron|NAGPA_uc002cyf.2_Intron|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_Missense_Mutation_p.R200T	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	425	Lumenal (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	ATAGGTACCTCTGGAGACGCT	0.607													0	0	0	0.001168	0	6	46										G	5077281	C	G	5077281	3	3	7	1	0	0	0	0	1	0	0	0	10144	913	32	1	285	1	NAGPA	16	5077281	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1737801	5077281	85277472	405	1874										
TXNDC11	51061	broad.mit.edu	37	chr16	11792004	11792004	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtctattaaaggatgactttCggccaggggattaaaaggta	12	5	1	1	rs143169078		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:11792004C>T	uc010buu.1	-	8	1227	c.1165G>A	c.(1165-1167)GAA>AAA	p.E389K	TXNDC11_uc002dbg.1_Missense_Mutation_p.E362K	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	389					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						GGATGACTTTCGGCCAGGGGA	0.512													0	0	0	0.006122	0	15	89										T	11792004	C	T	11792004	3	4	7	1	0	0	0	0	1	0	0	0	16789	893	31	1	1816	1	TXNDC11	16	11792004	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6714723	11792004	78562749	406	1875										
DNAH3	55567	broad.mit.edu	37	chr16	21063188	21063188	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aacttggccaccacgtcgcgGgctgttgggacacagatgca	13	12	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:21063188G>A	uc010vbe.1	-	29	4041	c.4041C>T	c.(4039-4041)GCC>GCT	p.A1347A		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1347	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CCACGTCGCGGGCTGTTGGGA	0.522													0	0	0	0.010504	0	20	44										A	21063188	G	A	21063188	2	1	7	1	0	0	0	0	0	0	0	1	4603	1246	43	2		2	DNAH3	16	21063188	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	9271184	21063188	69291565	407	1876										
DNAH3	55567	broad.mit.edu	37	chr16	21086798	21086798	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tatttcacgaagctgaacgtCacgttaacccaatccaactt	5	12	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:21086798C>T	uc010vbe.1	-	21	3054	c.3054G>A	c.(3052-3054)GTG>GTA	p.V1018V		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1018	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGCTGAACGTCACGTTAACCC	0.453													0	0	0	0.001855	0	12	58										T	21086798	C	T	21086798	2	4	7	1	0	0	0	0	0	0	0	1	4603	813	29	1		1	DNAH3	16	21086798	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	23610	21086798	69267955	408	1877										
DNAH3	55567	broad.mit.edu	37	chr16	21132082	21132082	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgccattgcagtggcagccgCgtgcatgctgggctctcctg	14	13	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:21132082C>T	uc010vbe.1	-	11	1678	c.1678G>A	c.(1678-1680)GCG>ACG	p.A560T	DNAH3_uc002die.2_Intron	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	560	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTGGCAGCCGCGTGCATGCTG	0.507													0	0	0	0.000602	0	5	25										T	21132082	C	T	21132082	3	4	7	1	0	0	0	0	1	0	0	0	4603	768	27	2	10879	2	DNAH3	16	21132082	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	45284	21132082	69222671	409	1878										
KIAA0556	23247	broad.mit.edu	37	chr16	27640096	27640096	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagctgaaatcatcaccgcgGaaagctattcactctgactt	8	11	4	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:27640096G>A	uc002dow.2	+	4	279	c.255G>A	c.(253-255)CGG>CGA	p.R85R		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	85										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CATCACCGCGGAAAGCTATTC	0.532													0	0	0	0.010729	0	12	97										A	27640096	G	A	27640096	2	1	7	1	0	0	0	0	0	0	0	1	8183	1161	41	1		1	KIAA0556	16	27640096	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6508014	27640096	62714657	410	1879										
SRCAP	10847	broad.mit.edu	37	chr16	30721411	30721411	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgacacccgagatgggcctGaagaaggtgctgaagaagag	16	7	0	7			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:30721411G>A	uc002dze.1	+	8	1481	c.1096G>A	c.(1096-1098)GAA>AAA	p.E366K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E223K|SRCAP_uc010bzz.1_5'UTR|SNORA30_uc002dzh.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	366	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGATGGGCCTGAAGAAGGTGC	0.587													0	0	0	0.000602	0	5	21										A	30721411	G	A	30721411	3	1	7	1	0	0	0	0	1	0	0	0	15134	1291	45	1	1118	1	SRCAP	16	30721411	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3081315	30721411	59633342	411	1880										
FBXL19	54620	broad.mit.edu	37	chr16	30941563	30941563	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctccgactcttcgggcacatCgctgagtgaggacgaagccc	12	14	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:30941563C>T	uc002eab.2	+	7	1177	c.1019C>T	c.(1018-1020)TCG>TTG	p.S340L	FBXL19_uc002dzz.1_Missense_Mutation_p.S28L|FBXL19_uc002eaa.1_Missense_Mutation_p.S239L	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	340	Ser-rich.						DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4						TCGGGCACATCGCTGAGTGAG	0.677													0	0	0	0.004482	0	7	41										T	30941563	C	T	30941563	3	4	7	1	0	0	0	0	1	0	0	0	5715	893	31	1	1045	1	FBXL19	16	30941563	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	220152	30941563	59413190	412	1881										
SETD1A	9739	broad.mit.edu	37	chr16	30991419	30991419	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggaactcgggcctggactcaGaggacatgagttacctgcgg	15	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:30991419G>C	uc002ead.1	+	14	4998	c.4312G>C	c.(4312-4314)GAG>CAG	p.E1438Q		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1438	Interaction with CFP1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCTGGACTCAGAGGACATGAG	0.458													0	0	0	0.004672	0	3	26										C	30991419	G	C	30991419	3	2	7	1	0	0	0	0	1	0	0	0	14130	943	33	1	4362	1	SETD1A	16	30991419	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	49856	30991419	59363334	413	1882										
N4BP1	9683	broad.mit.edu	37	chr16	48595890	48595890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atctctagaaatattcagccCtgtggcagcattctgtgtaa	8	9	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:48595890C>T	uc002efp.2	-	2	901	c.664G>A	c.(664-666)GGG>AGG	p.G222R		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	222					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				ATATTCAGCCCTGTGGCAGCA	0.408													0	0	0	0.001984	0	7	32										T	48595890	C	T	48595890	3	4	7	1	0	0	0	0	1	0	0	0	10109	681	24	2	2050	2	N4BP1	16	48595890	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	17604471	48595890	41758863	414	1883										
PDP2	57546	broad.mit.edu	37	chr16	66919264	66919264	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgaagtggagtaaagagttGcagcgcagcattctggagag	15	6	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:66919264G>A	uc002eqk.1	+	2	1239	c.1077G>A	c.(1075-1077)TTG>TTA	p.L359L		NM_020786	NP_065837	Q9P2J9	PDP2_HUMAN	pyruvate dehydrogenase phosphatase isoenzyme 2	359					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GTAAAGAGTTGCAGCGCAGCA	0.557													0	0	0	0.009096	0	4	54										A	66919264	G	A	66919264	2	1	7	1	0	0	0	0	0	0	0	1	11686	1310	46	2		2	PDP2	16	66919264	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	18323374	66919264	23435489	415	1884										
FHOD1	29109	broad.mit.edu	37	chr16	67271177	67271177	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgcgtgcgcaggtcgacgtCagtgcccgcagtgcccaggt	15	14	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:67271177C>T	uc002esl.2	-	9	1070	c.958G>A	c.(958-960)GAC>AAC	p.D320N	FHOD1_uc010ced.2_Missense_Mutation_p.D127N|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	320	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGGTCGACGTCAGTGCCCGCA	0.657													0	0	0	0.001368	0	12	37										T	67271177	C	T	67271177	3	4	7	1	0	0	0	0	1	0	0	0	5882	826	29	1	2592	1	FHOD1	16	67271177	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	351913	67271177	23083576	416	1885										
ATP6V0D1	9114	broad.mit.edu	37	chr16	67514862	67514862	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcgcggccccggctcacccTctagcgtctcgcactgcacc	9	20	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:67514862T>A	uc002ete.1	-	1	228	c.128A>T	c.(127-129)GAG>GTG	p.E43V	ATP6V0D1_uc010vjo.1_Missense_Mutation_p.E43V	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	43					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		CGGCTCACCCTCTAGCGTCTC	0.672													0	0	0	0.004007	0	13	38										A	67514862	T	A	67514862	3	1	7	1	0	0	0	0	1	0	0	0	1173	1551	54	5	959	5	ATP6V0D1	16	67514862	Missense_Mutation	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	243685	67514862	22839891	417	1886										
ATP6V0D1	9114	broad.mit.edu	37	chr16	67514906	67514906	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgaggtagtcggcctggctGagcaccccggccttcaggcc	14	14	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:67514906G>C	uc002ete.1	-	1	184	c.84C>G	c.(82-84)CTC>CTG	p.L28L	ATP6V0D1_uc010vjo.1_Silent_p.L28L	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	28					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		CGGCCTGGCTGAGCACCCCGG	0.652													0	0	0	0.007413	0	15	42										C	67514906	G	C	67514906	2	2	7	1	0	0	0	0	0	0	0	1	1173	1277	45	1		1	ATP6V0D1	16	67514906	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	44	67514906	22839847	418	1887										
HAS3	3038	broad.mit.edu	37	chr16	69143494	69143494	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agagcctttttgccttcctgGagcaccggcgcatgcgacgt	12	13	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:69143494G>C	uc010cfh.2	+	2	420	c.196G>C	c.(196-198)GAG>CAG	p.E66Q	HAS3_uc002ewk.2_Missense_Mutation_p.E66Q|HAS3_uc010vlk.1_Missense_Mutation_p.E66Q|HAS3_uc002ewl.2_Missense_Mutation_p.E66Q	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	66	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TGCCTTCCTGGAGCACCGGCG	0.647													0	0	0	0.006214	0	8	32										C	69143494	G	C	69143494	3	2	7	1	0	0	0	0	1	0	0	0	6963	1175	41	1	198	1	HAS3	16	69143494	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1628588	69143494	21211259	419	1888										
DDX19A	55308	broad.mit.edu	37	chr16	70400696	70400696	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcctgtgcagcagcagagacGagaagttccaggccttgtgt	13	10	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:70400696G>A	uc002eyv.2	+	9	1023	c.952G>A	c.(952-954)GAG>AAG	p.E318K	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Missense_Mutation_p.E319K|DDX19A_uc010cfq.1_Missense_Mutation_p.E73K|DDX19A_uc010cfr.2_Missense_Mutation_p.E168K|DDX19A_uc010cfs.2_Missense_Mutation_p.E141K|DDX19A_uc010vlz.1_Missense_Mutation_p.E287K|DDX19A_uc010vma.1_Missense_Mutation_p.E228K	NM_018332	NP_060802	Q9NUU7	DD19A_HUMAN	DDX19-like protein	318	Helicase C-terminal.				mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)				CAGCAGAGACGAGAAGTTCCA	0.542													0	0	0	0.004007	0	16	79										A	70400696	G	A	70400696	3	1	7	1	0	0	0	0	1	0	0	0	4346	1059	37	1	986	1	DDX19A	16	70400696	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1257202	70400696	19954057	420	1889										
FOXL1	2300	broad.mit.edu	37	chr16	86612413	86612413	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggtcccgagagacccggcctCcctctggccttcgcccccgc	11	21	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:86612413C>G	uc002fjr.2	+	1	299	c.84C>G	c.(82-84)CTC>CTG	p.L28L		NM_005250	NP_005241	Q12952	FOXL1_HUMAN	forkhead box L1	28					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1						GACCCGGCCTCCCTCTGGCCT	0.692													0	0	0	0.010729	0	6	41										G	86612413	C	G	86612413	2	3	7	1	0	0	0	0	0	0	0	1	6016	842	30	1		1	FOXL1	16	86612413	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	16211717	86612413	3742340	421	1890										
KLHDC4	54758	broad.mit.edu	37	chr16	87744970	87744970	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagaacagtgtctggtgattCggggccatggccacggaaaa	14	8	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:87744970C>T	uc002fki.2	-	9	961	c.915G>A	c.(913-915)CCG>CCA	p.P305P	KLHDC4_uc002fkh.1_5'Flank|KLHDC4_uc010cht.1_Silent_p.P124P|KLHDC4_uc002fkj.2_Silent_p.P274P|KLHDC4_uc002fkk.2_Silent_p.P124P|KLHDC4_uc002fkl.2_Silent_p.P248P|KLHDC4_uc010chu.1_Silent_p.P124P	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	305										pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		TCTGGTGATTCGGGGCCATGG	0.567													0	0	0	0.010729	0	12	62										T	87744970	C	T	87744970	2	4	7	1	0	0	0	0	0	0	0	1	8358	871	31	1		1	KLHDC4	16	87744970	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1132557	87744970	2609783	422	1891										
FANCA	2175	broad.mit.edu	37	chr16	89862344	89862344	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agggctgtgagtgagtatctGagtcagggtatgactgaaga	16	4	2	6			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:89862344G>A	uc002fou.1	-	11	1018	c.976C>T	c.(976-978)CAG>TAG	p.Q326*	FANCA_uc010vpn.1_Nonsense_Mutation_p.Q326*	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	326					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GTGAGTATCTGAGTCAGGGTA	0.512			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.006214	0	10	46										A	89862344	G	A	89862344	4	1	7	1	0	0	0	0	0	1	0	0	5662	1299	45	1	3523	1	FANCA	16	89862344	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2117374	89862344	492409	423	1892										
TCF25	22980	broad.mit.edu	37	chr16	89940210	89940210	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccaagcgggagcttggtgtCcggcgtcccgggggcgcagg	19	13	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr16:89940210C>T	uc002fpb.2	+	1	217	c.135C>T	c.(133-135)GTC>GTT	p.V45V	TCF25_uc010vpp.1_Silent_p.V45V	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	45					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		AGCTTGGTGTCCGGCGTCCCG	0.701													0	0	0	0.009096	0	4	12										T	89940210	C	T	89940210	2	4	7	1	0	0	0	0	0	0	0	1	15690	842	30	1		1	TCF25	16	89940210	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	77866	89940210	414543	424	1893										
FAM101B	359845	broad.mit.edu	37	chr17	293277	293277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cggagtcgtacttgaccaagGaggtgtacctgggcgggaga	17	8	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:293277G>A	uc002frj.2	-	2	387	c.113C>T	c.(112-114)TCC>TTC	p.S38F		NM_182705	NP_874364	Q8N5W9	F101B_HUMAN	hypothetical protein LOC359845	108											0		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.0216)		CTTGACCAAGGAGGTGTACCT	0.657													0	0	0	0.008291	0	10	48										A	293277	G	A	293277	3	1	7	1	0	0	0	0	1	0	0	0	5381	1174	41	1	325	1	FAM101B	17	293277	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		293277	80901933	425	1894										
SCARF1	8578	broad.mit.edu	37	chr17	1548932	1548932	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgccctttggggtccagctcGgacccctgagtcccccgagt	12	16	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:1548932G>A	uc002fsz.1	-	1	110	c.60C>T	c.(58-60)TCC>TCT	p.S20S	SCARF1_uc002fsy.1_Silent_p.S20S|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Silent_p.S20S	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	20	Extracellular (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGTCCAGCTCGGACCCCTGAG	0.687													0	0	0	0.009096	0	3	3										A	1548932	G	A	1548932	2	1	7	1	0	0	0	0	0	0	0	1	13883	1103	39	2		2	SCARF1	17	1548932	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1255655	1548932	79646278	426	1895										
OR3A1	4994	broad.mit.edu	37	chr17	3195373	3195373	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttggggccacagaagttgagCgtggacatggccacagtgtg	16	8	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:3195373C>T	uc002fvh.1	-	1	504	c.504G>A	c.(502-504)ACG>ACA	p.T168T		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						AGAAGTTGAGCGTGGACATGG	0.567													0	0	0	0.00361	0	44	74										T	3195373	C	T	3195373	2	4	7	1	0	0	0	0	0	0	0	1	11037	755	27	2		2	OR3A1	17	3195373	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1646441	3195373	77999837	427	1896										
CAMTA2	23125	broad.mit.edu	37	chr17	4877755	4877755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctgccatccgcttctccatCtgctccagtcgctctagtat	6	16	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:4877755C>G	uc002gah.1	-	12	2049	c.1941G>C	c.(1939-1941)CAG>CAC	p.Q647H	CAMTA2_uc010cku.1_Missense_Mutation_p.Q670H|CAMTA2_uc002gag.1_Missense_Mutation_p.Q646H|CAMTA2_uc002gai.1_Missense_Mutation_p.Q649H|CAMTA2_uc010ckv.1_Missense_Mutation_p.Q294H	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	647					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GCTTCTCCATCTGCTCCAGTC	0.587													0	0	0	0.006214	0	10	48										G	4877755	C	G	4877755	3	3	7	1	0	0	0	0	1	0	0	0	2614	912	32	1	1765	1	CAMTA2	17	4877755	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1682382	4877755	76317455	428	1897										
TP53	7157	broad.mit.edu	37	chr17	7578419	7578419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggggcagcgcctcacaacctCcgtcatgtgctgtgactgct	12	14	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:7578419C>T	uc002gim.2	-	5	705	c.511G>A	c.(511-513)GAG>AAG	p.E171K	TP53_uc002gig.1_Missense_Mutation_p.E171K|TP53_uc002gih.2_Missense_Mutation_p.E171K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E39K|TP53_uc010cng.1_Missense_Mutation_p.E39K|TP53_uc002gii.1_Missense_Mutation_p.E39K|TP53_uc010cnh.1_Missense_Mutation_p.E171K|TP53_uc010cni.1_Missense_Mutation_p.E171K|TP53_uc002gij.2_Missense_Mutation_p.E171K|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.E78K|TP53_uc002gio.2_Missense_Mutation_p.E39K|TP53_uc010vug.1_Missense_Mutation_p.E132K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	171	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E171*(10)|p.E171K(8)|p.0?(7)|p.E171G(3)|p.E171Q(3)|p.E171fs*10(3)|p.E171fs*3(2)|p.E171V(2)|p.E171D(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.E171fs*9(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.E171_V172delEV(1)|p.H168fs*69(1)|p.T170_E171insXX(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.E171A(1)|p.H168fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCACAACCTCCGTCATGTGC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00278	0	22	36										T	7578419	C	T	7578419	3	4	7	1	0	0	0	0	1	0	0	0	16378	864	30	1	787	1	TP53	17	7578419	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2700664	7578419	73616791	429	1898										
TP53	7157	broad.mit.edu	37	chr17	7578493	7578493	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcgggggtgtggaatcaaccCacagctgcacagggcaggtc	16	11	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:7578493C>G	uc002gim.2	-	5	631	c.437G>C	c.(436-438)TGG>TCG	p.W146S	TP53_uc002gig.1_Missense_Mutation_p.W146S|TP53_uc002gih.2_Missense_Mutation_p.W146S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.W14S|TP53_uc010cng.1_Missense_Mutation_p.W14S|TP53_uc002gii.1_Missense_Mutation_p.W14S|TP53_uc010cnh.1_Missense_Mutation_p.W146S|TP53_uc010cni.1_Missense_Mutation_p.W146S|TP53_uc002gij.2_Missense_Mutation_p.W146S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.W53S|TP53_uc002gio.2_Missense_Mutation_p.W14S|TP53_uc010vug.1_Missense_Mutation_p.W107S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	146	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		W -> S (in sporadic cancers; somatic mutation).|W -> C (in a sporadic cancer; somatic mutation).|W -> G (in sporadic cancers; somatic mutation).|W -> R (in sporadic cancers; somatic mutation).|W -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W146*(61)|p.0?(7)|p.W146R(5)|p.W146C(2)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.W146_S149>C(1)|p.W146fs*25(1)|p.W146S(1)|p.Q144fs*32(1)|p.W146fs*1(1)|p.W146_V147insXXXXXXX(1)|p.W146fs*22(1)|p.W146fs*23(1)|p.W146G(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAATCAACCCACAGCTGCAC	0.602		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006122	0	17	25										G	7578493	C	G	7578493	3	3	7	1	0	0	0	0	1	0	0	0	16378	595	21	4	861	4	TP53	17	7578493	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	74	7578493	73616717	430	1899										
MYH8	4626	broad.mit.edu	37	chr17	10310054	10310054	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgcttgggaatcctttcctAcagatgcggatgccttccag	10	12	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:10310054A>C	uc002gmm.2	-	19	2219	c.2124T>G	c.(2122-2124)TGT>TGG	p.C708W	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	708	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATCCTTTCCTACAGATGCGGA	0.378									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				0	0	0	0.002299	0	22	69										C	10310054	A	C	10310054	3	2	7	1	0	0	0	0	1	0	0	0	10041	389	14	5	3777	5	MYH8	17	10310054	Missense_Mutation	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	2731561	10310054	70885156	431	1900										
MYH1	4619	broad.mit.edu	37	chr17	10399384	10399384	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcctcgatctcagcctgcagCaggttggctctgcgctccac	10	16	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:10399384C>T	uc002gmo.2	-	35	5146	c.5052G>A	c.(5050-5052)CTG>CTA	p.L1684L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1684	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CAGCCTGCAGCAGGTTGGCTC	0.592													0	0	0	0.004007	0	16	45										T	10399384	C	T	10399384	2	4	7	1	0	0	0	0	0	0	0	1	10029	697	25	2		2	MYH1	17	10399384	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	89330	10399384	70795826	432	1901										
DNAH9	1770	broad.mit.edu	37	chr17	11656266	11656266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatccctgaatactgtcatgGatgataacaaggtatgaaat	8	6	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:11656266G>A	uc002gne.2	+	33	6795	c.6727G>A	c.(6727-6729)GAT>AAT	p.D2243N	DNAH9_uc010coo.2_Missense_Mutation_p.D1537N	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2243	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TACTGTCATGGATGATAACAA	0.453													0	0	0	0.006122	0	18	36										A	11656266	G	A	11656266	3	1	7	1	0	0	0	0	1	0	0	0	4608	1174	41	1	6857	1	DNAH9	17	11656266	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1256882	11656266	69538944	433	1902										
RICH2	9912	broad.mit.edu	37	chr17	12823090	12823090	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggtggaaatcccaaatattCaaaagcagaggaaacactta	8	7	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:12823090C>G	uc002gnr.3	+	6	733	c.406C>G	c.(406-408)CAA>GAA	p.Q136E	RICH2_uc010vvk.1_Missense_Mutation_p.Q136E|RICH2_uc010vvl.1_Missense_Mutation_p.Q136E|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Missense_Mutation_p.Q136E|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	136	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CCCAAATATTCAAAAGCAGAG	0.353													0	0	0	0.001984	0	7	14										G	12823090	C	G	12823090	3	3	7	1	0	0	0	0	1	0	0	0	13357	827	29	1	428	1	RICH2	17	12823090	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1166824	12823090	68372120	434	1903										
ZNF287	57336	broad.mit.edu	37	chr17	16466491	16466491	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccttctaaaatttcttttatCaccatccatggttcttccaa	2	12	4	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:16466491C>G	uc002gqi.2	-	5	1137	c.684G>C	c.(682-684)GTG>GTC	p.V228V		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	221	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TTTCTTTTATCACCATCCATG	0.373													0	0	0	0.00245	0	11	51										G	16466491	C	G	16466491	2	3	7	1	0	0	0	0	0	0	0	1	17822	813	29	1		1	ZNF287	17	16466491	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3643401	16466491	64728719	435	1904										
NOS2	4843	broad.mit.edu	37	chr17	26101427	26101427	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tattcattctgcatgtacttCatgaaggattctgcagccga	8	9	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:26101427C>A	uc002gzu.2	-	12	1596	c.1332G>T	c.(1330-1332)ATG>ATT	p.M444I	NOS2_uc010crh.1_Missense_Mutation_p.M444I|NOS2_uc010wab.1_Missense_Mutation_p.M444I	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	444					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GCATGTACTTCATGAAGGATT	0.557													1	0	3.07112e-06	0.010729	3.20101e-06	10	62										A	26101427	C	A	26101427	3	1	7	1	0	0	0	0	1	0	0	0	10543	826	29	3	2193	3	NOS2	17	26101427	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	9634936	26101427	55093783	436	1905										
KIAA0100	9703	broad.mit.edu	37	chr17	26945944	26945944	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acatcttcttgctgctttcgCagctccatcttgttagcccg	7	14	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:26945944C>A	uc002hbu.2	-	32	5787	c.5688G>T	c.(5686-5688)CTG>CTT	p.L1896L	KIAA0100_uc002hbt.2_Silent_p.L225L	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1896						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCTGCTTTCGCAGCTCCATCT	0.532													1	0	3.86212e-05	0.008291	3.98335e-05	10	36										A	26945944	C	A	26945944	2	1	7	1	0	0	0	0	0	0	0	1	8154	697	25	4		4	KIAA0100	17	26945944	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	844517	26945944	54249266	437	1906										
PROCA1	147011	broad.mit.edu	37	chr17	27030605	27030605	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gttggggtttgatcctggggGagattttctcttgtttacct	13	6	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:27030605G>T	uc002hcb.3	-	5	1191	c.988C>A	c.(988-990)CCC>ACC	p.P330T	PROCA1_uc010crv.2_Missense_Mutation_p.P256T|PROCA1_uc002hca.1_Missense_Mutation_p.P328T	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	356					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					GATCCTGGGGGAGATTTTCTC	0.547													1	0	1.55795e-14	0.012319	1.66406e-14	22	127										T	27030605	G	T	27030605	3	4	7	1	0	0	0	0	1	0	0	0	12546	1174	41	3	32	3	PROCA1	17	27030605	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	84661	27030605	54164605	438	1907										
RAD51L3	5892	broad.mit.edu	37	chr17	33428002	33428002	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcaccctgtaatgtggcactCtgctctgaggtcccccaggt	10	14	3	1	rs147669627		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:33428002C>G	uc002hir.2	-	10	1213	c.957G>C	c.(955-957)CAG>CAC	p.Q319H	RFFL_uc002hiq.2_Intron|RAD51L3_uc010ctj.2_Missense_Mutation_p.E138Q|RAD51L3_uc010wcd.1_Missense_Mutation_p.Q339H|RAD51L3_uc002his.2_Missense_Mutation_p.Q207H|RAD51L3_uc010ctk.2_Missense_Mutation_p.Q200H|RAD51L3_uc010wce.1_Missense_Mutation_p.Q200H|RAD51L3_uc002hit.2_Missense_Mutation_p.Q200H|RAD51L3_uc002hiu.2_Missense_Mutation_p.Q142H	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	319					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ATGTGGCACTCTGCTCTGAGG	0.527								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.007291	0	27	46										G	33428002	C	G	33428002	3	3	7	1	0	0	0	0	1	0	0	0	12990	912	32	1	33	1	RAD51L3	17	33428002	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6397397	33428002	47767208	439	1908										
GRB7	2886	broad.mit.edu	37	chr17	37901554	37901554	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtctcgccatctgcatccatCttgtttgggctccccaccct	7	17	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:37901554C>G	uc002hsr.2	+	10	1320	c.1070C>G	c.(1069-1071)TCT>TGT	p.S357C	GRB7_uc002hss.2_Missense_Mutation_p.S357C|GRB7_uc010cwc.2_Missense_Mutation_p.S357C|GRB7_uc002hst.2_Missense_Mutation_p.S357C	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	357					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGCATCCATCTTGTTTGGGC	0.597													0	0	0	0.003163	0	13	34										G	37901554	C	G	37901554	3	3	7	1	0	0	0	0	1	0	0	0	6759	913	32	1	1104	1	GRB7	17	37901554	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4473552	37901554	43293656	440	1909										
PSMD3	5709	broad.mit.edu	37	chr17	38140722	38140722	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccactcgagactttttgctCcccttcctggaagaggtgag	11	12	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:38140722C>T	uc002htn.1	+	2	560	c.396C>T	c.(394-396)CTC>CTT	p.L132L	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Silent_p.L33L	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	132					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					ACTTTTTGCTCCCCTTCCTGG	0.517													0	0	0	0.008291	0	8	59										T	38140722	C	T	38140722	2	4	7	1	0	0	0	0	0	0	0	1	12699	842	30	1		1	PSMD3	17	38140722	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	239168	38140722	43054488	441	1910										
CDC6	990	broad.mit.edu	37	chr17	38447912	38447912	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcttaagccggattctgcaaGacctcaaggtacattgagag	11	9	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:38447912G>C	uc002huj.1	+	4	862	c.652G>C	c.(652-654)GAC>CAC	p.D218H		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	218					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						GATTCTGCAAGACCTCAAGGT	0.348													0	0	0	0.010504	0	20	38										C	38447912	G	C	38447912	3	2	7	1	0	0	0	0	1	0	0	0	3083	942	33	1	662	1	CDC6	17	38447912	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	307190	38447912	42747298	442	1911										
KAT2A	2648	broad.mit.edu	37	chr17	40265686	40265686	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctacttgtcaatgaggcctCcctccttgagcttgaagtag	9	12	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:40265686C>G	uc002hyx.2	-	18	2555	c.2495G>C	c.(2494-2496)GGA>GCA	p.G832A	DHX58_uc002hyv.3_5'Flank|DHX58_uc002hyw.3_5'Flank|DHX58_uc010wgf.1_5'Flank	NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	832					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						AATGAGGCCTCCCTCCTTGAG	0.607													0	0	0	0.006214	0	8	48										G	40265686	C	G	40265686	3	3	7	1	0	0	0	0	1	0	0	0	7981	855	30	1	22	1	KAT2A	17	40265686	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1817774	40265686	40929524	443	1912										
PTRF	284119	broad.mit.edu	37	chr17	40556890	40556890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagcacttccacctggccctCgcggatcttcttgacgtgga	11	14	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:40556890C>T	uc002hzo.2	-	2	1147	c.988G>A	c.(988-990)GAG>AAG	p.E330K	PTRF_uc010wgi.1_Missense_Mutation_p.E312K	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	330					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		ACCTGGCCCTCGCGGATCTTC	0.687													0	0	0	0.003163	0	15	46										T	40556890	C	T	40556890	3	4	7	1	0	0	0	0	1	0	0	0	12815	893	31	1	188	1	PTRF	17	40556890	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	291204	40556890	40638320	444	1913										
DHX8	1659	broad.mit.edu	37	chr17	41599484	41599484	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaggccatctgcagtgggttCttccgtaatgctgccaagaa	11	10	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:41599484C>G	uc002idu.1	+	22	3406	c.3333C>G	c.(3331-3333)TTC>TTG	p.F1111L	DHX8_uc010wig.1_Missense_Mutation_p.F1111L	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1111						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		GCAGTGGGTTCTTCCGTAATG	0.517													0	0	0	0.00361	0	82	52										G	41599484	C	G	41599484	3	3	7	1	0	0	0	0	1	0	0	0	4515	912	32	1	3419	1	DHX8	17	41599484	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1042594	41599484	39595726	445	1914										
FMNL1	752	broad.mit.edu	37	chr17	43323891	43323891	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgatcaagacggtgcccttCacggcccgcaccggcaagcg	13	15	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:43323891C>T	uc002iin.2	+	26	3431	c.3231C>T	c.(3229-3231)TTC>TTT	p.F1077F	FMNL1_uc002iiq.2_Intron|FMNL1_uc010dag.2_Intron|LOC100133991_uc010dah.2_5'Flank	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	1077	DAD.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						CGGTGCCCTTCACGGCCCGCA	0.582											OREG0024478	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	18	42										T	43323891	C	T	43323891	2	4	7	1	0	0	0	0	0	0	0	1	5951	825	29	1		1	FMNL1	17	43323891	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1724407	43323891	37871319	446	1915										
PNPO	55163	broad.mit.edu	37	chr17	46023710	46023710	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atctgagaaagaaaaatgagGaactggaacagctctaccag	10	7	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:46023710G>A	uc002imo.2	+	6	721	c.568G>A	c.(568-570)GAA>AAA	p.E190K	PNPO_uc010wkz.1_Missense_Mutation_p.E172K|PNPO_uc010wla.1_Missense_Mutation_p.E95K|PNPO_uc010wlb.1_Missense_Mutation_p.E147K	NM_018129	NP_060599	Q9NVS9	PNPO_HUMAN	pyridoxine 5'-phosphate oxidase	190					pyridoxine biosynthetic process	cytosol	FMN binding|pyridoxamine-phosphate oxidase activity				0					Pyridoxal Phosphate(DB00114)	GAAAAATGAGGAACTGGAACA	0.493													0	0	0	0.009096	0	3	34										A	46023710	G	A	46023710	3	1	7	1	0	0	0	0	1	0	0	0	12172	1175	41	1	590	1	PNPO	17	46023710	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2699819	46023710	35171500	447	1916										
UBE2Z	65264	broad.mit.edu	37	chr17	47004453	47004453	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatggactctgatagcagttCatctgggacagagacagacc	11	9	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:47004453C>T	uc002ioi.2	+	7	1121	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L		NM_023079	NP_075567	Q9H832	UBE2Z_HUMAN	ubiquitin-conjugating enzyme E2Z	341					apoptosis	cytoplasm|nucleus	ATP binding|ubiquitin-protein ligase activity				0						GATAGCAGTTCATCTGGGACA	0.537													0	0	0	0.000602	0	4	29										T	47004453	C	T	47004453	3	4	7	1	0	0	0	0	1	0	0	0	16875	838	29	1	1048	1	UBE2Z	17	47004453	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	980743	47004453	34190757	448	1917										
ABCC3	8714	broad.mit.edu	37	chr17	48745049	48745049	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggcatcaggcagggtgagctCcagctgctgcgcacggcggc	17	13	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:48745049C>G	uc002isl.2	+	12	1646	c.1566C>G	c.(1564-1566)CTC>CTG	p.L522L	ABCC3_uc002isk.3_Silent_p.L522L	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	522	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AGGGTGAGCTCCAGCTGCTGC	0.632													0	0	0	0.001168	0	5	46										G	48745049	C	G	48745049	2	3	7	1	0	0	0	0	0	0	0	1	54	842	30	1		1	ABCC3	17	48745049	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1740596	48745049	32450161	449	1918										
MBTD1	54799	broad.mit.edu	37	chr17	49280217	49280217	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cactttccaccactgctactCgtgttcgacacaaatgcctc	5	16	0	0	rs147550029		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:49280217C>T	uc002itr.3	-	10	1252	c.908G>A	c.(907-909)CGA>CAA	p.R303Q	MBTD1_uc002itp.3_Missense_Mutation_p.R139Q|MBTD1_uc002itq.3_Missense_Mutation_p.R303Q	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	303	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CACTGCTACTCGTGTTCGACA	0.408													0	0	0	0.005524	0	37	185										T	49280217	C	T	49280217	3	4	7	1	0	0	0	0	1	0	0	0	9360	884	31	1	1010	1	MBTD1	17	49280217	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	535168	49280217	31914993	450	1919										
TRIM37	4591	broad.mit.edu	37	chr17	57089713	57089713	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcaggggcagctgaagctcCttcaggtagtacaggctgta	13	9	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:57089713C>A	uc002iwy.3	-	22	3115	c.2671G>T	c.(2671-2673)GGA>TGA	p.G891*	TRIM37_uc002iwz.3_Nonsense_Mutation_p.G891*|TRIM37_uc002ixa.3_Nonsense_Mutation_p.G769*|TRIM37_uc010woc.1_Nonsense_Mutation_p.G857*	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	891						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GCTGAAGCTCCTTCAGGTAGT	0.368									Mulibrey_Nanism				1	0	3.45872e-05	0.004007	3.57798e-05	13	75										A	57089713	C	A	57089713	4	1	7	1	0	0	0	0	0	1	0	0	16508	690	24	4	243	4	TRIM37	17	57089713	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	7809496	57089713	24105497	451	1920										
KPNA2	3838	broad.mit.edu	37	chr17	66042657	66042657	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgttgtaccagaaactacctCtgaaggctacactttccaag	7	12	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:66042657C>G	uc002jgk.2	+	11	1667	c.1535C>G	c.(1534-1536)TCT>TGT	p.S512C	KPNA2_uc002jgl.2_Missense_Mutation_p.S512C	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	512					DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GAAACTACCTCTGAAGGCTAC	0.368													0	0	0	0.008291	0	9	71										G	66042657	C	G	66042657	3	3	7	1	0	0	0	0	1	0	0	0	8430	913	32	1	1573	1	KPNA2	17	66042657	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	8952944	66042657	15152553	452	1921										
KPNA2	3838	broad.mit.edu	37	chr17	66042674	66042674	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctctgaaggctacactttcCaagttcaggatggggctcct	10	12	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:66042674C>A	uc002jgk.2	+	11	1684	c.1552C>A	c.(1552-1554)CAA>AAA	p.Q518K	KPNA2_uc002jgl.2_Missense_Mutation_p.Q518K	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	518					DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CTACACTTTCCAAGTTCAGGA	0.338													1	0	7.03913e-09	0.001368	7.44938e-09	12	78										A	66042674	C	A	66042674	3	1	7	1	0	0	0	0	1	0	0	0	8430	595	21	4	1590	4	KPNA2	17	66042674	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	17	66042674	15152536	453	1922										
KCNJ16	3773	broad.mit.edu	37	chr17	68128891	68128891	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acagttagagcccaacttctCcgctatacagaagacagtga	8	11	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:68128891C>G	uc002jin.2	+	5	1149	c.663C>G	c.(661-663)CTC>CTG	p.L221L	KCNJ16_uc002jio.2_Silent_p.L221L|KCNJ16_uc002jip.2_Silent_p.L221L|KCNJ16_uc002jiq.2_Silent_p.L253L	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	221	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CCCAACTTCTCCGCTATACAG	0.473													0	0	0	0.006214	0	9	51										G	68128891	C	G	68128891	2	3	7	1	0	0	0	0	0	0	0	1	8050	842	30	1		1	KCNJ16	17	68128891	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2086217	68128891	13066319	454	1923										
KCNJ16	3773	broad.mit.edu	37	chr17	68129403	68129403	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccctgaggagaccaccacttCcgccacacatgaatataggg	9	14	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:68129403C>T	uc002jin.2	+	5	1661	c.1175C>T	c.(1174-1176)TCC>TTC	p.S392F	KCNJ16_uc002jio.2_Missense_Mutation_p.S392F|KCNJ16_uc002jip.2_Missense_Mutation_p.S392F|KCNJ16_uc002jiq.2_Missense_Mutation_p.S424F	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	392	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					ACCACCACTTCCGCCACACAT	0.458													0	0	0	0.001168	0	5	55										T	68129403	C	T	68129403	3	4	7	1	0	0	0	0	1	0	0	0	8050	855	30	1	1177	1	KCNJ16	17	68129403	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	512	68129403	13065807	455	1924										
NUP85	79902	broad.mit.edu	37	chr17	73205991	73205991	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtagatgtttactctcaaatCttgagaaaactcttcaatga	6	7	4	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73205991C>T	uc002jng.1	+	3	461	c.201C>T	c.(199-201)ATC>ATT	p.I67I	NUP85_uc010dgd.1_Silent_p.I67I|NUP85_uc010wrv.1_Silent_p.I21I	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	67					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			ACTCTCAAATCTTGAGAAAAC	0.368													0	0	0	0.008291	0	9	69										T	73205991	C	T	73205991	2	4	7	1	0	0	0	0	0	0	0	1	10770	903	32	1		1	NUP85	17	73205991	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5076588	73205991	7989219	456	1925										
LLGL2	3993	broad.mit.edu	37	chr17	73554290	73554290	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caccaggagaacaacgctgtGacgcagatccacctcctgcc	9	16	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73554290G>A	uc002joh.2	+	4	382	c.228G>A	c.(226-228)GTG>GTA	p.V76V	LLGL2_uc002jog.1_Silent_p.V76V|LLGL2_uc010dgf.1_Silent_p.V76V|LLGL2_uc002joi.2_Silent_p.V76V|LLGL2_uc010dgg.1_Silent_p.V76V|LLGL2_uc002joj.2_Silent_p.V65V	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	76	WD 2.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			ACAACGCTGTGACGCAGATCC	0.632													0	0	0	0.008871	0	18	123										A	73554290	G	A	73554290	2	1	7	1	0	0	0	0	0	0	0	1	8834	1277	45	1		1	LLGL2	17	73554290	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	348299	73554290	7640920	457	1926										
RECQL5	9400	broad.mit.edu	37	chr17	73623508	73623508	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagccagcagttggtcatctCtgggggccacacaggccatg	13	13	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73623508C>G	uc010dgl.2	-	20	3126	c.2970G>C	c.(2968-2970)CAG>CAC	p.Q990H	RECQL5_uc010dgk.2_Missense_Mutation_p.Q963H|RECQL5_uc002jot.3_Missense_Mutation_p.Q186H	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	990					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TTGGTCATCTCTGGGGGCCAC	0.622								Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.007413	0	18	118										G	73623508	C	G	73623508	3	3	7	1	0	0	0	0	1	0	0	0	13203	912	32	1	9	1	RECQL5	17	73623508	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	69218	73623508	7571702	458	1927			3	7		5	5	1622	C		3.239488e-08
RECQL5	9400	broad.mit.edu	37	chr17	73623520	73623520	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggtcatctctgggggccacaCaggccatgccagtcagcttc	12	14	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73623520C>T	uc010dgl.2	-	20	3114	c.2958G>A	c.(2956-2958)CTG>CTA	p.L986L	RECQL5_uc010dgk.2_Silent_p.L959L|RECQL5_uc002jot.3_Silent_p.L182L	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	986					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GGGGGCCACACAGGCCATGCC	0.632								Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.012319	0	21	126										T	73623520	C	T	73623520	2	4	7	1	0	0	0	0	0	0	0	1	13203	465	17	2		2	RECQL5	17	73623520	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	12	73623520	7571690	459	1928			3	7		5	5	1622	C		3.239488e-08
RECQL5	9400	broad.mit.edu	37	chr17	73624402	73624402	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcggagagctggaaggggtCttgagccgtgggattcaagg	19	6	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73624402C>G	uc010dgl.2	-	18	2857	c.2701G>C	c.(2701-2703)GAC>CAC	p.D901H	RECQL5_uc010dgk.2_Missense_Mutation_p.D874H|RECQL5_uc002jot.3_Missense_Mutation_p.D97H	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	901					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TGGAAGGGGTCTTGAGCCGTG	0.602								Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.00499	0	16	103										G	73624402	C	G	73624402	3	3	7	1	0	0	0	0	1	0	0	0	13203	913	32	1	286	1	RECQL5	17	73624402	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	882	73624402	7570808	460	1929			3	7		5	5	1622	C		3.239488e-08
RECQL5	9400	broad.mit.edu	37	chr17	73624837	73624837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgccctggtctctgggcgggCaggtgctggtagagggaaga	19	8	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73624837C>T	uc010dgl.2	-	17	2651	c.2495G>A	c.(2494-2496)TGC>TAC	p.C832Y	RECQL5_uc010dgk.2_Missense_Mutation_p.C805Y|RECQL5_uc002jot.3_Missense_Mutation_p.C28Y	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	832					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCTGGGCGGGCAGGTGCTGGT	0.652								Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.00308	0	7	42										T	73624837	C	T	73624837	3	4	7	1	0	0	0	0	1	0	0	0	13203	710	25	2	496	2	RECQL5	17	73624837	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	435	73624837	7570373	461	1930			3	7		5	5	1622	C		3.239488e-08
RECQL5	9400	broad.mit.edu	37	chr17	73625129	73625129	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgggggtccctgaaccccctCacaggaggggcaggcacctt	14	15	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:73625129C>T	uc010dgl.2	-	16	2530	c.2374G>A	c.(2374-2376)GAG>AAG	p.E792K	RECQL5_uc010dgk.2_Missense_Mutation_p.E765K|RECQL5_uc002jot.3_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	792					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			TGAACCCCCTCACAGGAGGGG	0.642								Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.001168	0	6	53										T	73625129	C	T	73625129	3	4	7	1	0	0	0	0	1	0	0	0	13203	835	29	1	621	1	RECQL5	17	73625129	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	292	73625129	7570081	462	1931			3	7		5	5	1622	C		3.239488e-08
GALR2	8811	broad.mit.edu	37	chr17	74071212	74071212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgctgcgtgcccttccaggCcaccatctacaccctggacg	10	17	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:74071212C>T	uc002jqm.1	+	1	329	c.248C>T	c.(247-249)GCC>GTC	p.A83V	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	83	Extracellular (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						CCCTTCCAGGCCACCATCTAC	0.632													0	0	0	0.010729	0	11	77										T	74071212	C	T	74071212	3	4	7	1	0	0	0	0	1	0	0	0	6228	739	26	2	250	2	GALR2	17	74071212	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	446083	74071212	7123998	463	1932										
MGAT5B	146664	broad.mit.edu	37	chr17	74901357	74901357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaggctcacagcccagtgggCgctggctgcccagcgcctgg	16	15	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:74901357C>T	uc002jti.2	+	6	933	c.830C>T	c.(829-831)GCG>GTG	p.A277V	MGAT5B_uc002jth.2_Missense_Mutation_p.A266V	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	266	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GCCCAGTGGGCGCTGGCTGCC	0.642													0	0	0	0.010729	0	9	37										T	74901357	C	T	74901357	3	4	7	1	0	0	0	0	1	0	0	0	9549	768	27	2	924	2	MGAT5B	17	74901357	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	830145	74901357	6293853	464	1933										
AZI1	22994	broad.mit.edu	37	chr17	79165000	79165000	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggcgggtccttaccggctctCggcagccttctcactctcct	10	17	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:79165000C>T	uc002jzp.1	-	22	2967	c.2767G>A	c.(2767-2769)GAG>AAG	p.E923K	AZI1_uc002jzm.1_Missense_Mutation_p.E355K|AZI1_uc002jzn.1_Missense_Mutation_p.E920K|AZI1_uc002jzo.1_Missense_Mutation_p.E884K|AZI1_uc010wum.1_Missense_Mutation_p.E887K|AZI1_uc002jzq.2_Missense_Mutation_p.E71K	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	923					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TACCGGCTCTCGGCAGCCTTC	0.652													0	0	0	0.010504	0	20	66										T	79165000	C	T	79165000	3	4	7	1	0	0	0	0	1	0	0	0	1240	893	31	1	504	1	AZI1	17	79165000	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4263643	79165000	2030210	465	1934										
C17orf62	79415	broad.mit.edu	37	chr17	80401915	80401915	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agggtcaccggcctcactgtCgctgctctgagacagctctg	12	14	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:80401915C>T	uc002kez.2	-	6	577	c.529G>A	c.(529-531)GAC>AAC	p.D177N	C17orf62_uc002kex.2_Silent_p.A28A|C17orf62_uc002key.2_Silent_p.A28A|C17orf62_uc002kfa.2_Missense_Mutation_p.D177N|C17orf62_uc010dir.2_Missense_Mutation_p.D177N|C17orf62_uc002kfb.3_Missense_Mutation_p.D177N|C17orf62_uc002kfc.3_Missense_Mutation_p.D163N|C17orf62_uc002kfd.3_Silent_p.A28A|C17orf62_uc002kfe.3_Silent_p.A28A	NM_001100407	NP_001093877	Q9BQA9	CQ062_HUMAN	hypothetical protein LOC79415 isoform a	177						integral to membrane	protein binding				0	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GCCTCACTGTCGCTGCTCTGA	0.652													0	0	0	0.008871	0	19	135										T	80401915	C	T	80401915	3	4	7	1	0	0	0	0	1	0	0	0	1870	884	31	1	38	1	C17orf62	17	80401915	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1236915	80401915	793295	466	1935										
FN3K	64122	broad.mit.edu	37	chr17	80708353	80708353	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccgcgttgctccacggggatCtctggtcgggaaacgtggct	15	12	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr17:80708353C>G	uc010wvs.1	+	6	713	c.652C>G	c.(652-654)CTC>GTC	p.L218V	TBCD_uc002kfx.1_5'Flank|TBCD_uc002kfy.1_5'Flank|TBCD_uc002kfz.2_5'Flank	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	218					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			CCACGGGGATCTCTGGTCGGG	0.567													0	0	0	0.003163	0	16	118										G	80708353	C	G	80708353	3	3	7	1	0	0	0	0	1	0	0	0	5963	913	32	1	674	1	FN3K	17	80708353	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	306438	80708353	486857	467	1936										
EMILIN2	84034	broad.mit.edu	37	chr18	2892402	2892402	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agagacatttctggcctgaaGaattcagtccagcagttcta	9	9	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr18:2892402G>C	uc002kln.2	+	4	2436	c.2277G>C	c.(2275-2277)AAG>AAC	p.K759N		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	759					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CTGGCCTGAAGAATTCAGTCC	0.468													0	0	0	0.001855	0	14	48										C	2892402	G	C	2892402	3	2	7	1	0	0	0	0	1	0	0	0	5094	933	33	1	2291	1	EMILIN2	18	2892402	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		2892402	75184846	468	1937										
LAMA1	284217	broad.mit.edu	37	chr18	7024444	7024444	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	accacttcatctccatcattGaggtggcaggtggggctgaa	12	10	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr18:7024444G>C	uc002knm.2	-	18	2518	c.2424C>G	c.(2422-2424)CTC>CTG	p.L808L	LAMA1_uc010wzj.1_Silent_p.L284L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	808	Laminin EGF-like 7.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCATCATTGAGGTGGCAGG	0.438													0	0	0	0.009096	0	3	17										C	7024444	G	C	7024444	2	2	7	1	0	0	0	0	0	0	0	1	8605	1277	45	1		1	LAMA1	18	7024444	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	4132042	7024444	71052804	469	1938										
MOCOS	55034	broad.mit.edu	37	chr18	33780103	33780103	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgcctttggacctgtcagctCaccaggccgactttgtcccc	9	17	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr18:33780103C>T	uc002kzq.3	+	4	780	c.757C>T	c.(757-759)CAC>TAC	p.H253Y		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	253					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	CCTGTCAGCTCACCAGGCCGA	0.587													0	0	0	0.004007	0	14	37										T	33780103	C	T	33780103	3	4	7	1	0	0	0	0	1	0	0	0	9689	826	29	1	771	1	MOCOS	18	33780103	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	26755659	33780103	44297145	470	1939										
C18orf22	79863	broad.mit.edu	37	chr18	77794586	77794586	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgcgctatttccaggctgcGagcggggacttcactgctct	12	13	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr18:77794586G>A	uc002lns.2	+	1	229	c.91G>A	c.(91-93)GAG>AAG	p.E31K	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Missense_Mutation_p.E31K|C18orf22_uc010dri.1_RNA	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	31					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		TCCAGGCTGCGAGCGGGGACT	0.682													0	0	0	0.010729	0	11	17										A	77794586	G	A	77794586	3	1	7	1	0	0	0	0	1	0	0	0	1898	1059	37	1	93	1	C18orf22	18	77794586	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	44014483	77794586	282662	471	1940										
RPS15	6209	broad.mit.edu	37	chr19	1440120	1440120	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagcgcctgcgcaaggccaaGaaggaggcgccgcccatgga	15	13	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:1440120G>A	uc002lsp.1	+	3	254	c.192G>A	c.(190-192)AAG>AAA	p.K64K	RPS15_uc002lsq.1_Silent_p.K71K	NM_001018	NP_001009	P62841	RS15_HUMAN	ribosomal protein S15	64					endocrine pancreas development|ribosomal small subunit export from nucleus|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	DNA binding|protein binding|RNA binding				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAAGGCCAAGAAGGAGGCGC	0.662													0	0	0	0.004672	0	3	12										A	1440120	G	A	1440120	2	1	7	1	0	0	0	0	0	0	0	1	13625	933	33	1		1	RPS15	19	1440120	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		1440120	57688863	472	1941										
DOT1L	84444	broad.mit.edu	37	chr19	2210632	2210632	+	Nonsense_Mutation	SNP	G	G	T													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcctccaggactctggtgctGaggaagagaaggcgggagca							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2210632G>T	uc002lvb.3	+	14	1165	c.1129G>T	c.(1129-1131)GAG>TAG	p.E377*	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	377						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTGGTGCTGAGGAAGAGAA	0.632													1	0	8.34094e-07	0.008871	8.7333e-07	19	148										T	2210632	G	T	2210632	4	4	7	1	0	0	0	0	0	1	0	0	4709	1291	45	3	1183	3	DOT1L	19	2210632	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	770512	2210632	56918351	473	1942	13	2	4	8		7	6	6068	N	G	1.330337e-07
DOT1L	84444	broad.mit.edu	37	chr19	2210638	2210638	+	Missense_Mutation	SNP	G	G	A													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggactctggtgctgaggaaGagaaggcgggagcagccacc							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2210638G>A	uc002lvb.3	+	14	1171	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	379						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTGAGGAAGAGAAGGCGGG	0.642													0	0	0	0.010504	0	20	151										A	2210638	G	A	2210638	3	1	7	1	0	0	0	0	1	0	0	0	4709	943	33	1	1189	1	DOT1L	19	2210638	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6	2210638	56918345	474	1943	13	2	4	8		7	6	6068	N	G	1.330337e-07
DOT1L	84444	broad.mit.edu	37	chr19	2210754	2210754	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgcgggcgccccaagaagatGaacactgcgaaccccgagcg	13	15	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2210754G>A	uc002lvb.3	+	14	1287	c.1251G>A	c.(1249-1251)ATG>ATA	p.M417I	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	417						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAGAAGATGAACACTGCGA	0.617													0	0	0	0.006214	0	10	66										A	2210754	G	A	2210754	3	1	7	1	0	0	0	0	1	0	0	0	4709	1290	45	1	1305	1	DOT1L	19	2210754	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	116	2210754	56918229	475	1944			4	8		7	6	6068	N	G	1.330337e-07
DOT1L	84444	broad.mit.edu	37	chr19	2213597	2213597	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcagccactgccaggcccaGaaggaggagatcaggaggct	14	12	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2213597G>A	uc002lvb.3	+	17	1653	c.1617G>A	c.(1615-1617)CAG>CAA	p.Q539Q	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	539						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGCCCAGAAGGAGGAGA	0.632													0	0	0	0.001984	0	6	51										A	2213597	G	A	2213597	2	1	7	1	0	0	0	0	0	0	0	1	4709	933	33	1		1	DOT1L	19	2213597	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2843	2213597	56915386	476	1945			4	8		7	6	6068	N	G	1.330337e-07
DOT1L	84444	broad.mit.edu	37	chr19	2213856	2213856	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccatgtccccagctgggtgtGaaggcgctgacctacaacga	12	13	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2213856G>A	uc002lvb.3	+	18	1704	c.1668G>A	c.(1666-1668)GTG>GTA	p.V556V	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	556						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGGGTGTGAAGGCGCTGA	0.642													0	0	0	0.00308	0	8	66										A	2213856	G	A	2213856	2	1	7	1	0	0	0	0	0	0	0	1	4709	1277	45	1		1	DOT1L	19	2213856	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	259	2213856	56915127	477	1946			4	8		7	6	6068	N	G	1.330337e-07
DOT1L	84444	broad.mit.edu	37	chr19	2216484	2216484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acttgagcagcatgagcccgGagctctccatgaacggccag	12	13	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2216484G>A	uc002lvb.3	+	20	2164	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	DOT1L_uc002lvc.1_Missense_Mutation_p.E4K|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Missense_Mutation_p.E4K	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	710						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATGAGCCCGGAGCTCTCCAT	0.672													0	0	0	0.001368	0	12	47										A	2216484	G	A	2216484	3	1	7	1	0	0	0	0	1	0	0	0	4709	1175	41	1	2206	1	DOT1L	19	2216484	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2628	2216484	56912499	478	1947			4	8		7	6	6068	N	G	1.330337e-07
DOT1L	84444	broad.mit.edu	37	chr19	2216699	2216699	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tccccggccaagattgtgctGaggcggcacctgagccagga	14	13	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:2216699G>A	uc002lvb.3	+	20	2379	c.2343G>A	c.(2341-2343)CTG>CTA	p.L781L	DOT1L_uc002lvc.1_Silent_p.L75L|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Silent_p.L75L	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	781						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATTGTGCTGAGGCGGCACC	0.692													0	0	0	0.00308	0	7	61										A	2216699	G	A	2216699	2	1	7	1	0	0	0	0	0	0	0	1	4709	1277	45	1		1	DOT1L	19	2216699	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	215	2216699	56912284	479	1948			4	8		7	6	6068	N	G	1.330337e-07
ZBTB7A	51341	broad.mit.edu	37	chr19	4048050	4048050	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccgttgcagccgtctttcttGaggtgtctgtgcaggtggtc	14	10	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:4048050G>A	uc002lzh.2	-	3	1530	c.1455C>T	c.(1453-1455)CTC>CTT	p.L485L	ZBTB7A_uc002lzi.2_Silent_p.L485L	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	485	C2H2-type 4; atypical.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTCTTTCTTGAGGTGTCTGT	0.408													0	0	0	0.001984	0	6	23										A	4048050	G	A	4048050	2	1	7	1	0	0	0	0	0	0	0	1	17550	1277	45	1		1	ZBTB7A	19	4048050	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1831351	4048050	55080933	480	1949										
KIAA1543	57662	broad.mit.edu	37	chr19	7676406	7676406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctcatcgcctcccccaggctCcctgaagtcttccccgtcca	6	21	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:7676406C>T	uc002mgv.3	+	10	1228	c.1127C>T	c.(1126-1128)TCC>TTC	p.S376F	KIAA1543_uc002mgu.3_Missense_Mutation_p.S403F	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	376					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CCCCCAGGCTCCCTGAAGTCT	0.632													0	0	0	0.004672	0	3	5										T	7676406	C	T	7676406	3	4	7	1	0	0	0	0	1	0	0	0	8243	855	30	1	1254	1	KIAA1543	19	7676406	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3628356	7676406	51452577	481	1950										
KIAA1543	57662	broad.mit.edu	37	chr19	7676584	7676584	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccgcccagccgtcccctctCccaggctgtgtcattcagca	9	19	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:7676584C>G	uc002mgv.3	+	11	1306	c.1205C>G	c.(1204-1206)TCC>TGC	p.S402C	KIAA1543_uc002mgu.3_Missense_Mutation_p.S429C|KIAA1543_uc002mgw.2_5'Flank	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	402					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CGTCCCCTCTCCCAGGCTGTG	0.692													0	0	0	0.004672	0	3	10										G	7676584	C	G	7676584	3	3	7	1	0	0	0	0	1	0	0	0	8243	855	30	1	1336	1	KIAA1543	19	7676584	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	178	7676584	51452399	482	1951										
MUC16	94025	broad.mit.edu	37	chr19	9075858	9075858	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tccaggagtcagatgtagctCttgcctctgttgtaagagct	11	9	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:9075858C>G	uc002mkp.2	-	3	11792	c.11588G>C	c.(11587-11589)AGA>ACA	p.R3863T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3864	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGATGTAGCTCTTGCCTCTGT	0.453													0	0	0	0.006214	0	10	33										G	9075858	C	G	9075858	3	3	7	1	0	0	0	0	1	0	0	0	9973	913	32	1	32263	1	MUC16	19	9075858	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1399274	9075858	50053125	483	1952										
TYK2	7297	broad.mit.edu	37	chr19	10478793	10478793	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	catcccctgtgctgtctgatCtgaggatgcctcggttcctg	11	13	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:10478793C>G	uc002moc.3	-	5	781	c.403G>C	c.(403-405)GAT>CAT	p.D135H	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Missense_Mutation_p.D135H	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	135	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCTGTCTGATCTGAGGATGCC	0.567													0	0	0	0.006214	0	9	27										G	10478793	C	G	10478793	3	3	7	1	0	0	0	0	1	0	0	0	16807	913	32	1	3244	1	TYK2	19	10478793	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1402935	10478793	48650190	484	1953										
DOCK6	57572	broad.mit.edu	37	chr19	11343960	11343960	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gggttgctgctgctgatgctCttggaacgcgccaggtagag	16	9	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:11343960C>G	uc002mqs.3	-	22	2678	c.2637G>C	c.(2635-2637)AAG>AAC	p.K879N	DOCK6_uc010xlq.1_Missense_Mutation_p.K183N	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	879					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TGCTGATGCTCTTGGAACGCG	0.657													0	0	0	0.003163	0	12	23										G	11343960	C	G	11343960	3	3	7	1	0	0	0	0	1	0	0	0	4691	912	32	1	3614	1	DOCK6	19	11343960	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	865167	11343960	47785023	485	1954										
CCDC130	81576	broad.mit.edu	37	chr19	13873412	13873412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctctcctctagcctacgagGacaagcagaaactcaagcgg	9	14	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:13873412G>A	uc002mxb.1	+	11	1224	c.721G>A	c.(721-723)GAC>AAC	p.D241N	CCDC130_uc002mxc.1_Missense_Mutation_p.D241N|CCDC130_uc002mxd.1_Missense_Mutation_p.D96N|CCDC130_uc010dzf.1_Missense_Mutation_p.D135N|MRI1_uc002mxe.2_5'Flank|MRI1_uc002mxf.2_5'Flank	NM_030818	NP_110445	P13994	CC130_HUMAN	coiled-coil domain containing 130	241					response to virus		protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			AGCCTACGAGGACAAGCAGAA	0.622													0	0	0	0.004672	0	3	25										A	13873412	G	A	13873412	3	1	7	1	0	0	0	0	1	0	0	0	2766	1174	41	1	755	1	CCDC130	19	13873412	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2529452	13873412	45255571	486	1955										
AKAP8L	26993	broad.mit.edu	37	chr19	15510131	15510131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acctttccaccatgcggtctCgctgccgctttttctgcttg	8	15	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:15510131C>T	uc002naw.1	-	9	1238	c.1139G>A	c.(1138-1140)CGA>CAA	p.R380Q	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.R319Q	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	380						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CATGCGGTCTCGCTGCCGCTT	0.617													0	0	0	0.001368	0	9	42										T	15510131	C	T	15510131	3	4	7	1	0	0	0	0	1	0	0	0	458	884	31	1	825	1	AKAP8L	19	15510131	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1636719	15510131	43618852	487	1956										
OR10H1	26539	broad.mit.edu	37	chr19	15918161	15918161	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttccgaccttcagcagaaggGatcttcaagatggcggccac	11	12	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:15918161G>C	uc002nbq.2	-	1	776	c.687C>G	c.(685-687)ATC>ATG	p.I229M		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAGCAGAAGGGATCTTCAAGA	0.567													0	0	0	0.006214	0	9	51										C	15918161	G	C	15918161	3	2	7	1	0	0	0	0	1	0	0	0	10905	1164	41	1	273	1	OR10H1	19	15918161	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	408030	15918161	43210822	488	1957										
NWD1	284434	broad.mit.edu	37	chr19	16860125	16860125	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gctgatgcccagaaccttctCagcagcctcaaaagtcacat	7	14	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:16860125C>T	uc002neu.3	+	6	1094	c.672C>T	c.(670-672)CTC>CTT	p.L224L	NWD1_uc002net.3_Silent_p.L89L|NWD1_uc002nev.3_Silent_p.L18L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	224							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						AGAACCTTCTCAGCAGCCTCA	0.587													0	0	0	0.008871	0	21	57										T	16860125	C	T	16860125	2	4	7	1	0	0	0	0	0	0	0	1	10781	813	29	1		1	NWD1	19	16860125	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	941964	16860125	42268858	489	1958										
MYO9B	4650	broad.mit.edu	37	chr19	17311468	17311468	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccccctccggacagcagcatCgccacgctgcaggtgagaag	12	16	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:17311468C>T	uc010eak.2	+	26	4545	c.4393C>T	c.(4393-4395)CGC>TGC	p.R1465C	MYO9B_uc002nfi.2_Missense_Mutation_p.R1465C|MYO9B_uc002nfj.1_Missense_Mutation_p.R1465C|MYO9B_uc002nfl.1_Missense_Mutation_p.R14C	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1465	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						ACAGCAGCATCGCCACGCTGC	0.602													0	0	0	0.001168	0	6	15										T	17311468	C	T	17311468	3	4	7	1	0	0	0	0	1	0	0	0	10085	884	31	1	4491	1	MYO9B	19	17311468	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	451343	17311468	41817515	490	1959										
COMP	1311	broad.mit.edu	37	chr19	18896563	18896563	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgtctggaaggccctgaagtCggtgagcgtgacttcagcgt	15	9	2	3	rs145034923		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:18896563C>T	uc002nke.2	-	14	1624	c.1588G>A	c.(1588-1590)GAC>AAC	p.D530N	COMP_uc002nkd.2_Missense_Mutation_p.D497N|COMP_uc010xqj.1_Missense_Mutation_p.D477N	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	530	Mediates cell survival and induction of the IAP family of survival proteins.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						GCCCTGAAGTCGGTGAGCGTG	0.627													0	0	0	0.006122	0	16	29										T	18896563	C	T	18896563	3	4	7	1	0	0	0	0	1	0	0	0	3724	884	31	1	709	1	COMP	19	18896563	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1585095	18896563	40232420	491	1960										
ZNF681	148213	broad.mit.edu	37	chr19	23926476	23926476	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctttgaagtgttttcaaaatCactgttacatcttttaggtt	6	6	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:23926476C>T	uc002nrk.3	-	4	2018	c.1876G>A	c.(1876-1878)GAT>AAT	p.D626N	ZNF681_uc002nrl.3_Missense_Mutation_p.D557N|ZNF681_uc002nrj.3_Missense_Mutation_p.D557N	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTTTCAAAATCACTGTTACAT	0.308													0	0	0	0.00308	0	7	8										T	23926476	C	T	23926476	3	4	7	1	0	0	0	0	1	0	0	0	18085	826	29	1	65	1	ZNF681	19	23926476	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5029913	23926476	35202507	492	1961										
ZNF681	148213	broad.mit.edu	37	chr19	23926861	23926861	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttctctccagtatgaattctCttatgtgtagtaaggattga	8	6	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:23926861C>G	uc002nrk.3	-	4	1633	c.1491G>C	c.(1489-1491)AAG>AAC	p.K497N	ZNF681_uc002nrl.3_Missense_Mutation_p.K428N|ZNF681_uc002nrj.3_Missense_Mutation_p.K428N	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	497	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TATGAATTCTCTTATGTGTAG	0.358													0	0	0	0.008871	0	20	55										G	23926861	C	G	23926861	3	3	7	1	0	0	0	0	1	0	0	0	18085	912	32	1	450	1	ZNF681	19	23926861	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	385	23926861	35202122	493	1962										
ZNF681	148213	broad.mit.edu	37	chr19	23927978	23927978	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggttaagtccattataacctCctttttgcactttgcactca	5	11	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:23927978C>G	uc002nrk.3	-	4	516	c.374G>C	c.(373-375)GGA>GCA	p.G125A	ZNF681_uc002nrl.3_Missense_Mutation_p.G56A|ZNF681_uc002nrj.3_Missense_Mutation_p.G56A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ATTATAACCTCCTTTTTGCAC	0.294													0	0	0	0.001984	0	7	24										G	23927978	C	G	23927978	3	3	7	1	0	0	0	0	1	0	0	0	18085	855	30	1	1567	1	ZNF681	19	23927978	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1117	23927978	35201005	494	1963										
ZNF536	9745	broad.mit.edu	37	chr19	31039228	31039228	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cacccacttctctgagatcgGaagagcttatcaaagcattg	8	11	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:31039228G>A	uc002nsu.1	+	4	2840	c.2702G>A	c.(2701-2703)GGA>GAA	p.G901E	ZNF536_uc010edd.1_Missense_Mutation_p.G901E	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	901					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCTGAGATCGGAAGAGCTTAT	0.512													0	0	0	0.012213	0	33	202										A	31039228	G	A	31039228	3	1	7	1	0	0	0	0	1	0	0	0	17971	1174	41	1	2712	1	ZNF536	19	31039228	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7111250	31039228	28089755	495	1964										
ANKRD27	84079	broad.mit.edu	37	chr19	33089074	33089074	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggaccgggaagcactaacctCttggggagtggagagggggc	19	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:33089074C>G	uc002ntn.1	-	29	3286	c.3130G>C	c.(3130-3132)GAG>CAG	p.E1044Q		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	1044					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GCACTAACCTCTTGGGGAGTG	0.587													0	0	0	0.00361	0	42	58										G	33089074	C	G	33089074	3	3	7	1	0	0	0	0	1	0	0	0	655	922	32	1	26	1	ANKRD27	19	33089074	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2049846	33089074	26039909	496	1965										
MLL4	9757	broad.mit.edu	37	chr19	36218436	36218436	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccccgctggcgagaggccctGagcggggccctccagggggg	19	15	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:36218436G>C	uc010eei.2	+	17	4215	c.4215G>C	c.(4213-4215)CTG>CTC	p.L1405L		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1405					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGAGGCCCTGAGCGGGGCCC	0.687													0	0	0	0.004007	0	16	118										C	36218436	G	C	36218436	2	2	7	1	0	0	0	0	0	0	0	1	9623	1277	45	1		1	MLL4	19	36218436	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3129362	36218436	22910547	497	1966										
NPHS1	4868	broad.mit.edu	37	chr19	36322010	36322010	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agctgggggctgaagtccctCagggagcggtaatacggctc	16	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:36322010C>T	uc002oby.2	-	27	3426	c.3426G>A	c.(3424-3426)CTG>CTA	p.L1142L	NPHS1_uc010eem.1_RNA	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1142	Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGAAGTCCCTCAGGGAGCGGT	0.587													0	0	0	0.003163	0	15	145										T	36322010	C	T	36322010	2	4	7	1	0	0	0	0	0	0	0	1	10582	813	29	1		1	NPHS1	19	36322010	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	103574	36322010	22806973	498	1967										
ZNF567	163081	broad.mit.edu	37	chr19	37211048	37211048	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagagaacacatacaggggaGaaatcttatgaatgtcctca	9	8	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:37211048G>A	uc010xtl.1	+	6	1644	c.1422G>A	c.(1420-1422)GAG>GAA	p.E474E	ZNF567_uc002oeo.1_Silent_p.E474E|ZNF567_uc010xtk.1_Silent_p.E474E|ZNF567_uc002oep.3_Silent_p.E443E|ZNF567_uc002oeq.1_Silent_p.E443E	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	474					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATACAGGGGAGAAATCTTATG	0.418													0	0	0	0.004878	0	36	51										A	37211048	G	A	37211048	2	1	7	1	0	0	0	0	0	0	0	1	17995	933	33	1		1	ZNF567	19	37211048	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	889038	37211048	21917935	499	1968										
RYR1	6261	broad.mit.edu	37	chr19	38976369	38976369	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcagccacgtagaccaagctCagctgctgcacgccctggag	12	15	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:38976369C>G	uc002oit.2	+	34	5204	c.5074C>G	c.(5074-5076)CAG>GAG	p.Q1692E	RYR1_uc002oiu.2_Missense_Mutation_p.Q1692E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1692	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGACCAAGCTCAGCTGCTGCA	0.667													0	0	0	0.00874	0	39	81										G	38976369	C	G	38976369	3	3	7	1	0	0	0	0	1	0	0	0	13768	827	29	1	5208	1	RYR1	19	38976369	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1765321	38976369	20152614	500	1969										
ACTN4	81	broad.mit.edu	37	chr19	39219769	39219769	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggctgaccaggtcatcgcttCcttcaaggtcttagcagggg	13	11	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:39219769C>T	uc002oja.1	+	20	2611	c.2552C>T	c.(2551-2553)TCC>TTC	p.S851F	ACTN4_uc002ojb.1_Missense_Mutation_p.S173F	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	851					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTCATCGCTTCCTTCAAGGTC	0.637													0	0	0	0.010729	0	10	89										T	39219769	C	T	39219769	3	4	7	1	0	0	0	0	1	0	0	0	207	855	30	1	2630	1	ACTN4	19	39219769	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	243400	39219769	19909214	501	1970										
RINL	126432	broad.mit.edu	37	chr19	39361468	39361468	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgaatggtgagcacgtcctCagggccttcctcttcagggt	13	11	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:39361468C>A	uc002ojq.2	-	8	812	c.424G>T	c.(424-426)GAG>TAG	p.E142*	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Nonsense_Mutation_p.E256*	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	142							GTPase activator activity			pancreas(1)	1						AGCACGTCCTCAGGGCCTTCC	0.622													1	0	1.17673e-23	0.00361	1.26078e-23	53	61										A	39361468	C	A	39361468	4	1	7	1	0	0	0	0	0	1	0	0	13375	835	29	3	954	3	RINL	19	39361468	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	141699	39361468	19767515	502	1971										
RINL	126432	broad.mit.edu	37	chr19	39361736	39361736	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acctggatcatgtctctgagCagcctctggctctgtttctt	9	12	5	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:39361736C>T	uc002ojq.2	-	7	629	c.241G>A	c.(241-243)GCT>ACT	p.A81T	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Missense_Mutation_p.A195T	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	81							GTPase activator activity			pancreas(1)	1						TGTCTCTGAGCAGCCTCTGGC	0.622													0	0	0	0.00361	0	62	94										T	39361736	C	T	39361736	3	4	7	1	0	0	0	0	1	0	0	0	13375	710	25	2	1141	2	RINL	19	39361736	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	268	39361736	19767247	503	1972										
FBXO27	126433	broad.mit.edu	37	chr19	39521863	39521863	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	attcacctgaatgaagtcacGaagcacgtctgagaaggggc	12	9	3	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:39521863G>A	uc002okh.2	-	3	544	c.462C>T	c.(460-462)TTC>TTT	p.F154F		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	154	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ATGAAGTCACGAAGCACGTCT	0.582													0	0	0	0.010504	0	19	140										A	39521863	G	A	39521863	2	1	7	1	0	0	0	0	0	0	0	1	5737	1049	37	1		1	FBXO27	19	39521863	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	160127	39521863	19607120	504	1973										
PRX	57716	broad.mit.edu	37	chr19	40902869	40902869	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gagctccacctctgggagtcGaacctctggaagggctgcct	13	13	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:40902869G>A	uc002onr.2	-	7	1659	c.1390C>T	c.(1390-1392)CGA>TGA	p.R464*	PRX_uc002onq.2_Nonsense_Mutation_p.R325*|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	464	5.|55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCTGGGAGTCGAACCTCTGGA	0.612													0	0	0	0.00361	0	70	145										A	40902869	G	A	40902869	4	1	7	1	0	0	0	0	0	1	0	0	12642	1066	37	1	2999	1	PRX	19	40902869	Nonsense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1381006	40902869	18226114	505	1974										
ADCK4	79934	broad.mit.edu	37	chr19	41209631	41209631	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccctctcacctggatcttcaCggccacctccgtcccgtccc	6	22	3	0	rs146225943	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:41209631C>T	uc002oor.2	-	8	1008	c.706G>A	c.(706-708)GTG>ATG	p.V236M	ADCK4_uc002oop.1_5'Flank|ADCK4_uc002ooq.1_Missense_Mutation_p.V195M	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	236	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			TGGATCTTCACGGCCACCTCC	0.522													0	0	0	0.001168	0	6	70										T	41209631	C	T	41209631	3	4	7	1	0	0	0	0	1	0	0	0	290	536	19	2	960	2	ADCK4	19	41209631	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	306762	41209631	17919352	506	1975										
TMEM145	284339	broad.mit.edu	37	chr19	42819374	42819374	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatgtgaccttcctcctcatCttcatcctcatcttcttcct	3	16	6	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:42819374C>G	uc002otk.1	+	7	592	c.540C>G	c.(538-540)ATC>ATG	p.I180M		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	180	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				tcctcctcatcttcatcctca	0.463													0	0	0	0.00245	0	15	75										G	42819374	C	G	42819374	3	3	7	1	0	0	0	0	1	0	0	0	16056	903	32	1	566	1	TMEM145	19	42819374	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1609743	42819374	16309609	507	1976										
C19orf61	56006	broad.mit.edu	37	chr19	44235749	44235749	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gacattcctctccttggcctCaggccagcaggcggctgtac	11	15	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:44235749C>G	uc002oxj.2	-	14	1905	c.1562G>C	c.(1561-1563)TGA>TCA	p.*521S		NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	521					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				TCCTTGGCCTCAGGCCAGCAG	0.637													0	0	0	0.001368	0	12	70										G	44235749	C	G	44235749	4	3	7	1	0	0	0	0	0	0	0	0	1943	837	29	1	4	1	C19orf61	19	44235749	Nonstop_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1416375	44235749	14893234	508	1977										
SYMPK	8189	broad.mit.edu	37	chr19	46330779	46330779	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggggatcaccttgtccttctCatgggagctgaggtcgagga	15	9	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:46330779C>T	uc002pdn.2	-	16	2415	c.2170G>A	c.(2170-2172)GAG>AAG	p.E724K	SYMPK_uc002pdo.1_Missense_Mutation_p.E724K|SYMPK_uc002pdp.1_Missense_Mutation_p.E724K	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	724					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		TTGTCCTTCTCATGGGAGCTG	0.597													0	0	0	0.001855	0	13	32										T	46330779	C	T	46330779	3	4	7	1	0	0	0	0	1	0	0	0	15436	835	29	1	1702	1	SYMPK	19	46330779	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2095030	46330779	12798204	509	1978										
PRKD2	25865	broad.mit.edu	37	chr19	47207801	47207801	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cggaggtgccgaggcgcaccGagtggccactggccagagac	17	13	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:47207801G>A	uc002pfh.2	-	5	959	c.617C>T	c.(616-618)TCG>TTG	p.S206L	PRKD2_uc002pfg.2_Missense_Mutation_p.S49L|PRKD2_uc002pfi.2_Missense_Mutation_p.S206L|PRKD2_uc002pfj.2_Missense_Mutation_p.S206L|PRKD2_uc010xye.1_Missense_Mutation_p.S206L|PRKD2_uc002pfk.2_Missense_Mutation_p.S49L	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	206					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GAGGCGCACCGAGTGGCCACT	0.657											OREG0025578	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	24	55										A	47207801	G	A	47207801	3	1	7	1	0	0	0	0	1	0	0	0	12519	1059	37	1	2079	1	PRKD2	19	47207801	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	877022	47207801	11921182	510	1979										
DHX34	9704	broad.mit.edu	37	chr19	47856690	47856690	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agagagtggctgagttccgcCgagccctgttgcactacctg	13	12	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:47856690C>G	uc010xyn.1	+	2	744	c.403C>G	c.(403-405)CGA>GGA	p.R135G	DHX34_uc010elc.1_Missense_Mutation_p.R135G	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	135						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TGAGTTCCGCCGAGCCCTGTT	0.652													0	0	0	0.010729	0	10	119										G	47856690	C	G	47856690	3	3	7	1	0	0	0	0	1	0	0	0	4507	644	23	4	405	4	DHX34	19	47856690	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	648889	47856690	11272293	511	1980										
KDELR1	10945	broad.mit.edu	37	chr19	48892915	48892915	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcccatcgtaagtagctttGaacttgctataaatcaacca	5	10	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:48892915G>A	uc002pjb.1	-	3	441	c.246C>T	c.(244-246)TTC>TTT	p.F82F	KDELR1_uc002pja.1_Silent_p.F20F	NM_006801	NP_006792	P24390	ERD21_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum	82	Cytoplasmic (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane|membrane fraction	KDEL sequence binding|protein binding|receptor activity				0		all_epithelial(76;2.48e-06)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Prostate(7;0.122)|Breast(70;0.203)		all cancers(93;0.000114)|OV - Ovarian serous cystadenocarcinoma(262;0.000136)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.0145)		AAGTAGCTTTGAACTTGCTAT	0.532													0	0	0	0.010729	0	12	74										A	48892915	G	A	48892915	2	1	7	1	0	0	0	0	0	0	0	1	8119	1281	45	1		1	KDELR1	19	48892915	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1036225	48892915	10236068	512	1981										
FAM83E	54854	broad.mit.edu	37	chr19	49113235	49113235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggctctggaagctgcagcccCgcacgacacggacatccacg	12	16	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:49113235C>T	uc002pjn.2	-	3	721	c.656G>A	c.(655-657)CGG>CAG	p.R219Q		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	219										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GCTGCAGCCCCGCACGACACG	0.627													0	0	0	0.003954	0	24	15										T	49113235	C	T	49113235	3	4	7	1	0	0	0	0	1	0	0	0	5637	652	23	2	792	2	FAM83E	19	49113235	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	220320	49113235	10015748	513	1982										
BAX	581	broad.mit.edu	37	chr19	49458852	49458852	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agacaggggcccttttgcttCaggggtgagtttgaggtctg	16	7	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:49458852C>T	uc002plk.2	+	2	151	c.82C>T	c.(82-84)CAG>TAG	p.Q28*	BAX_uc002plf.1_Nonsense_Mutation_p.Q28*|BAX_uc002plg.1_Intron|BAX_uc002plh.1_Intron|BAX_uc010xzx.1_RNA|BAX_uc002plj.2_Nonsense_Mutation_p.Q28*|BAX_uc002pll.2_Nonsense_Mutation_p.Q28*|BAX_uc002plm.2_Intron	NM_138761	NP_620116	Q07812	BAX_HUMAN	BCL2-associated X protein isoform alpha	28					activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|B cell apoptosis|cleavage of lamin|DNA fragmentation involved in apoptotic nuclear change|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		CCTTTTGCTTCAGGGGTGAGT	0.527													0	0	0	0.00361	0	52	59										T	49458852	C	T	49458852	4	4	7	1	0	0	0	0	0	1	0	0	1328	827	29	1	88	1	BAX	19	49458852	Nonsense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	345617	49458852	9670131	514	1983										
BAX	581	broad.mit.edu	37	chr19	49464129	49464129	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggctggacattggacttcctCcgggagcggctgttgggctg	17	10	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:49464129C>T	uc002plk.2	+	5	501	c.432C>T	c.(430-432)CTC>CTT	p.L144L	BAX_uc002plf.1_Silent_p.L144L|BAX_uc002plg.1_Silent_p.L107L|BAX_uc002plh.1_Silent_p.L66L|BAX_uc010xzx.1_RNA|BAX_uc002plj.2_Silent_p.L144L|BAX_uc002pll.2_Silent_p.L95L|BAX_uc002plm.2_Silent_p.L66L	NM_138761	NP_620116	Q07812	BAX_HUMAN	BCL2-associated X protein isoform alpha	144					activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|B cell apoptosis|cleavage of lamin|DNA fragmentation involved in apoptotic nuclear change|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		TGGACTTCCTCCGGGAGCGGC	0.483													0	0	0	0.013114	0	45	46										T	49464129	C	T	49464129	2	4	7	1	0	0	0	0	0	0	0	1	1328	842	30	1		1	BAX	19	49464129	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5277	49464129	9664854	515	1984										
RUVBL2	10856	broad.mit.edu	37	chr19	49510338	49510338	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgccggcagtgaaatcttctCcctggagatgagcaagaccg	12	12	2	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:49510338C>T	uc002plr.1	+	5	342	c.329C>T	c.(328-330)TCC>TTC	p.S110F	RUVBL2_uc002plq.1_Missense_Mutation_p.S65F|RUVBL2_uc010yab.1_Missense_Mutation_p.S110F|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.S65F|RUVBL2_uc010yac.1_Missense_Mutation_p.S65F	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	110					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GAAATCTTCTCCCTGGAGATG	0.657													0	0	0	0.007413	0	15	71										T	49510338	C	T	49510338	3	4	7	1	0	0	0	0	1	0	0	0	13753	855	30	1	347	1	RUVBL2	19	49510338	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	46209	49510338	9618645	516	1985										
MED25	81857	broad.mit.edu	37	chr19	50334032	50334032	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccagctccccaactaccccCaggaccccctggcgccccca	6	25	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:50334032C>G	uc002ppw.1	+	9	1042	c.989C>G	c.(988-990)CCA>CGA	p.P330R	MED25_uc010ybe.1_Missense_Mutation_p.P117R|MED25_uc002ppx.1_Missense_Mutation_p.P111R	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	330	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		CAACTACCCCCAGGACCCCCT	0.706													0	0	0	0.00623	0	40	38										G	50334032	C	G	50334032	3	3	7	1	0	0	0	0	1	0	0	0	9443	594	21	4	1023	4	MED25	19	50334032	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	823694	50334032	8794951	517	1986										
PPP2R1A	5518	broad.mit.edu	37	chr19	52724377	52724377	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caccgcatgactacgctcttCtgcatcaatgtgagccttcc	7	15	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:52724377C>T	uc002pyp.2	+	12	1668	c.1509C>T	c.(1507-1509)TTC>TTT	p.F503F	PPP2R1A_uc010ydk.1_Silent_p.F448F|PPP2R1A_uc002pyq.2_Silent_p.F324F	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	503	PP2A subunit C binding.|HEAT 13.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CTACGCTCTTCTGCATCAATG	0.592			Mis		clear cell ovarian carcinoma								0	0	0	0.00361	0	57	64										T	52724377	C	T	52724377	2	4	7	1	0	0	0	0	0	0	0	1	12382	912	32	1		1	PPP2R1A	19	52724377	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2390345	52724377	6404606	518	1987										
ZNF808	388558	broad.mit.edu	37	chr19	53057257	53057257	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acacctttcacgccatcaaaGacttcatactggagtgaaac	6	12	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:53057257G>C	uc010epq.1	+	5	1265	c.1088G>C	c.(1087-1089)AGA>ACA	p.R363T	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	363	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CGCCATCAAAGACTTCATACT	0.383													0	0	0	0.001984	0	7	121										C	53057257	G	C	53057257	3	2	7	1	0	0	0	0	1	0	0	0	18170	942	33	1	1098	1	ZNF808	19	53057257	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	332880	53057257	6071726	519	1988										
BIRC8	112401	broad.mit.edu	37	chr19	53793212	53793212	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcgttttatagttgctcccaGatgtttgaattctttcctcc	7	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:53793212G>C	uc002qbk.2	-	1	1664	c.416C>G	c.(415-417)TCT>TGT	p.S139C		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	139					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		GTTGCTCCCAGATGTTTGAAT	0.383													0	0	0	0.00278	0	23	210										C	53793212	G	C	53793212	3	2	7	1	0	0	0	0	1	0	0	0	1440	942	33	1	298	1	BIRC8	19	53793212	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	735955	53793212	5335771	520	1989										
KIR2DL3	3804	broad.mit.edu	37	chr19	55263168	55263168	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcctcttcatcctcctcctCttctttctccttcatcgctg	2	18	6	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:55263168C>G	uc002qgv.2	+	6	801	c.783C>G	c.(781-783)CTC>CTG	p.L261L	KIR2DL3_uc002qgx.2_Silent_p.L261L|KIR2DL3_uc002qgy.2_Silent_p.L163L|KIR2DL3_uc010erw.1_Silent_p.L261L|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	261	Helical; (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		tcctcctcctcttctttctcc	0.423													0	0	0	0.010504	0	21	133										G	55263168	C	G	55263168	2	3	7	1	0	0	0	0	0	0	0	1	8317	900	32	1		1	KIR2DL3	19	55263168	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1469956	55263168	3865815	521	1990										
NLRP7	199713	broad.mit.edu	37	chr19	55441934	55441934	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatccacaatccacgagctaTctggttgatactcaagtcca	6	12	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:55441934T>A	uc002qih.3	-	9	2819	c.2743A>T	c.(2743-2745)ATA>TTA	p.I915L	NLRP7_uc002qig.3_Missense_Mutation_p.I887L|NLRP7_uc002qii.3_Missense_Mutation_p.I915L|NLRP7_uc010esk.2_Missense_Mutation_p.I915L|NLRP7_uc010esl.2_Missense_Mutation_p.I943L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	915	LRR 8.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CCACGAGCTATCTGGTTGATA	0.418													0	0	0	0.001855	0	14	154										A	55441934	T	A	55441934	3	1	7	1	0	0	0	0	1	0	0	0	10482	1435	50	5	382	5	NLRP7	19	55441934	Missense_Mutation	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	178766	55441934	3687049	522	1991										
PPP1R12C	54776	broad.mit.edu	37	chr19	55624149	55624149	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aagcgcaccacctccaggttCtcatcaatgcaggcctgggg	11	14	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:55624149C>T	uc002qix.2	-	2	352	c.336G>A	c.(334-336)GAG>GAA	p.E112E	PPP1R12C_uc010yfs.1_Silent_p.E38E|PPP1R12C_uc002qiy.2_Silent_p.E112E	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	112	ANK 1.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CCTCCAGGTTCTCATCAATGC	0.647													0	0	0	0.004482	0	8	90										T	55624149	C	T	55624149	2	4	7	1	0	0	0	0	0	0	0	1	12356	912	32	1		1	PPP1R12C	19	55624149	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	182215	55624149	3504834	523	1992										
U2AF2	11338	broad.mit.edu	37	chr19	56180822	56180822	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccccacagagcaccatcaatCagacgcctgtgaccctgcaa	7	17	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:56180822C>G	uc002qlu.2	+	11	2112	c.1057C>G	c.(1057-1059)CAG>GAG	p.Q353E	U2AF2_uc002qlt.2_Missense_Mutation_p.Q349E	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	353					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CACCATCAATCAGACGCCTGT	0.662													0	0	0	0.007413	0	19	23										G	56180822	C	G	56180822	3	3	7	1	0	0	0	0	1	0	0	0	16820	827	29	1	1099	1	U2AF2	19	56180822	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	556673	56180822	2948161	524	1993										
ZNF671	79891	broad.mit.edu	37	chr19	58232514	58232514	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttcccacattcgttacactCataaggcctttctccagtgt	5	13	2	0	rs144079819		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:58232514C>G	uc002qpz.3	-	4	1039	c.940G>C	c.(940-942)GAG>CAG	p.E314Q	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.E237Q|ZNF671_uc010yhf.1_Missense_Mutation_p.E216Q	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	314	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCGTTACACTCATAAGGCCTT	0.493													0	0	0	0.001368	0	12	126										G	58232514	C	G	58232514	3	3	7	1	0	0	0	0	1	0	0	0	18075	835	29	1	668	1	ZNF671	19	58232514	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2051692	58232514	896469	525	1994										
ZNF671	79891	broad.mit.edu	37	chr19	58233027	58233027	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgctacaaaaatgctctgctCagaagatacctcttcatcct	5	12	4	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:58233027C>G	uc002qpz.3	-	4	526	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.E66Q|ZNF671_uc010yhf.1_Missense_Mutation_p.E45Q	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATGCTCTGCTCAGAAGATACC	0.468													0	0	0	0.001368	0	11	92										G	58233027	C	G	58233027	3	3	7	1	0	0	0	0	1	0	0	0	18075	835	29	1	1181	1	ZNF671	19	58233027	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	513	58233027	895956	526	1995										
ZNF544	27300	broad.mit.edu	37	chr19	58772988	58772988	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tgctgccttccccatggcctCatctttttctgactgtaaca	6	14	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:58772988C>T	uc010euo.2	+	7	1490	c.1016C>T	c.(1015-1017)TCA>TTA	p.S339L	ZNF544_uc010yhw.1_RNA|ZNF544_uc010yhx.1_Missense_Mutation_p.S311L|ZNF544_uc010yhy.1_Missense_Mutation_p.S311L|ZNF544_uc002qrt.3_Missense_Mutation_p.S197L|ZNF544_uc002qru.3_Missense_Mutation_p.S197L|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		CCCATGGCCTCATCTTTTTCT	0.473													0	0	0	0.002299	0	22	62										T	58772988	C	T	58772988	3	4	7	1	0	0	0	0	1	0	0	0	17974	838	29	1	1030	1	ZNF544	19	58772988	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	539961	58772988	355995	527	1996										
TRIM28	10155	broad.mit.edu	37	chr19	59060782	59060782	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgtgcttatggctcttgcgGagggtcctggtgctgagggt	17	8	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr19:59060782G>A	uc002qtg.1	+	13	2036	c.1747G>A	c.(1747-1749)GAG>AAG	p.E583K	TRIM28_uc010eut.1_Missense_Mutation_p.E501K|TRIM28_uc002qth.1_Missense_Mutation_p.E198K	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	583					epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		GGCTCTTGCGGAGGGTCCTGG	0.652													0	0	0	0.003954	0	25	159										A	59060782	G	A	59060782	3	1	7	1	0	0	0	0	1	0	0	0	16499	1175	41	1	1797	1	TRIM28	19	59060782	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	287794	59060782	68201	528	1997										
CSNK2A1	1457	broad.mit.edu	37	chr20	469330	469330	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttcatgacttacctgcccaaGatatcattgaaacgtggatc	7	10	2	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:469330G>C	uc002wdw.1	-	11	1209	c.816C>G	c.(814-816)ATC>ATG	p.I272M	CSNK2A1_uc002wdx.1_Missense_Mutation_p.I272M|CSNK2A1_uc002wdy.1_Missense_Mutation_p.I136M	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	272	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			ACCTGCCCAAGATATCATTGA	0.358													0	0	0	0.010729	0	12	51										C	469330	G	C	469330	3	2	7	1	0	0	0	0	1	0	0	0	3957	932	33	1	375	1	CSNK2A1	20	469330	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		469330	62556190	529	1998										
SLC4A11	83959	broad.mit.edu	37	chr20	3210005	3210005	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aactcactctcgatttcccgGaagccatgggagctgatgag	11	11	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:3210005G>T	uc002wig.2	-	14	1932	c.1884C>A	c.(1882-1884)TTC>TTA	p.F628L	SLC4A11_uc010zqe.1_Missense_Mutation_p.F655L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.F612L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	628	Membrane (bicarbonate transporter).|Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CGATTTCCCGGAAGCCATGGG	0.667													1	0	2.0095e-06	0.001984	2.10084e-06	6	49										T	3210005	G	T	3210005	3	4	7	1	0	0	0	0	1	0	0	0	14652	1165	41	3	815	3	SLC4A11	20	3210005	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2740675	3210005	59815515	530	1999										
SLC23A2	9962	broad.mit.edu	37	chr20	4848512	4848512	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acacaggagaggccttccacGaaaattcccctaagatgtaa	8	11	0	2	rs72552221	byFrequency	TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:4848512G>A	uc002wlg.1	-	13	1635	c.1260C>T	c.(1258-1260)TTC>TTT	p.F420F	SLC23A2_uc010zqr.1_Silent_p.F305F|SLC23A2_uc002wlh.1_Silent_p.F420F	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	420				GIFVEGL -> YVPEKTS (in Ref. 10).	L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GGCCTTCCACGAAAATTCCCC	0.403													0	0	0	0.00308	0	7	21										A	4848512	G	A	4848512	2	1	7	1	0	0	0	0	0	0	0	1	14463	1049	37	1		1	SLC23A2	20	4848512	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1638507	4848512	58177008	531	2000										
LRRN4	164312	broad.mit.edu	37	chr20	6022478	6022478	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtggggtggaggcagctgaGatatcaggctcaaggacaag	17	6	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:6022478G>C	uc002wmo.2	-	5	1637	c.1413C>G	c.(1411-1413)ATC>ATG	p.I471M		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	471	Extracellular (Potential).					integral to membrane				skin(3)	3						AGGCAGCTGAGATATCAGGCT	0.647													0	0	0	0.007413	0	17	74										C	6022478	G	C	6022478	3	2	7	1	0	0	0	0	1	0	0	0	9037	932	33	1	813	1	LRRN4	20	6022478	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1173966	6022478	57003042	532	2001										
CRNKL1	51340	broad.mit.edu	37	chr20	20031155	20031155	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atcatttaattcttcttcatCtgtgatcttctgttgaggtg	7	7	7	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:20031155C>A	uc002wrs.2	-	3	678	c.646G>T	c.(646-648)GAT>TAT	p.D216Y	C20orf26_uc010gcw.1_5'Flank|C20orf26_uc010zse.1_5'Flank|C20orf26_uc002wru.2_5'Flank|CRNKL1_uc002wrt.1_Missense_Mutation_p.D204Y	NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	216					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						TCTTCTTCATCTGTGATCTTC	0.408													1	0	2.23348e-06	0.004007	2.33147e-06	17	42										A	20031155	C	A	20031155	3	1	7	1	0	0	0	0	1	0	0	0	3891	913	32	3	1952	3	CRNKL1	20	20031155	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	14008677	20031155	42994365	533	2002										
GZF1	64412	broad.mit.edu	37	chr20	23350821	23350821	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	acaagactgaacagcctgacGaagagtatgtgtcatccaag	10	9	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:23350821G>A	uc010gdb.2	+	7	2053	c.1879G>A	c.(1879-1881)GAA>AAA	p.E627K	GZF1_uc002wsy.2_Missense_Mutation_p.E627K|GZF1_uc010zsq.1_Missense_Mutation_p.E151K|GZF1_uc010zsr.1_Missense_Mutation_p.E136K|GZF1_uc002wsz.2_Missense_Mutation_p.E627K	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	627					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					ACAGCCTGACGAAGAGTATGT	0.448													0	0	0	0.006214	0	9	29										A	23350821	G	A	23350821	3	1	7	1	0	0	0	0	1	0	0	0	6914	1059	37	1	1897	1	GZF1	20	23350821	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3319666	23350821	39674699	534	2003										
HM13	81502	broad.mit.edu	37	chr20	30137129	30137129	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggactcttcatctacgatgtCttctgggtgagtcaggcagg	13	9	6	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:30137129C>A	uc002wwe.2	+	6	774	c.660C>A	c.(658-660)GTC>GTA	p.V220V	HM13_uc002wwc.2_Silent_p.V220V|HM13_uc002wwd.2_Silent_p.V220V|HM13_uc002wwf.2_Silent_p.V96V|HM13_uc010gdu.2_Silent_p.V96V	NM_030789	NP_110416	Q8TCT9	HM13_HUMAN	minor histocompatibility antigen 13 isoform 1	220	Helical; (Potential).				membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)	1	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			TCTACGATGTCTTCTGGGTGA	0.562													1	0	1.66031e-10	0.003954	1.76248e-10	23	167										A	30137129	C	A	30137129	2	1	7	1	0	0	0	0	0	0	0	1	7217	900	32	3		3	HM13	20	30137129	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	6786308	30137129	32888391	535	2004										
ZNF341	84905	broad.mit.edu	37	chr20	32379155	32379155	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccttcgcagagccggacgcGgtgctgtccatcgttgtggg	15	13	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:32379155G>A	uc002wzy.2	+	15	2417	c.2397G>A	c.(2395-2397)GCG>GCA	p.A799A	ZNF341_uc002wzx.2_Silent_p.A792A|ZNF341_uc010geq.2_Silent_p.A709A|ZNF341_uc010ger.2_RNA|ZNF341_uc002wzz.2_Silent_p.A226A	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	799					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGCCGGACGCGGTGCTGTCCA	0.701													0	0	0	0.004482	0	6	54										A	32379155	G	A	32379155	2	1	7	1	0	0	0	0	0	0	0	1	17854	1103	39	2		2	ZNF341	20	32379155	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	2242026	32379155	30646365	536	2005										
TP53INP2	58476	broad.mit.edu	37	chr20	33296631	33296631	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcgccttcgtgtcggaggagGatgaagtggacggctggctc	18	9	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:33296631G>C	uc002xau.1	+	3	423	c.88G>C	c.(88-90)GAT>CAT	p.D30H		NM_021202	NP_067025	Q8IXH6	T53I2_HUMAN	tumor protein p53 inducible nuclear protein 2	30						nucleus					0						GTCGGAGGAGGATGAAGTGGA	0.652													0	0	0	0.009096	0	4	37										C	33296631	G	C	33296631	3	2	7	1	0	0	0	0	1	0	0	0	16386	1174	41	1	90	1	TP53INP2	20	33296631	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	917476	33296631	29728889	537	2006										
TRPC4AP	26133	broad.mit.edu	37	chr20	33632447	33632447	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agaatccggcagaaattagcGagctgctgctgatcgaaatt	11	8	0	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:33632447G>A	uc002xbk.2	-	7	760	c.726C>T	c.(724-726)CTC>CTT	p.L242L	TRPC4AP_uc002xbl.2_Silent_p.L242L|TRPC4AP_uc010zur.1_Silent_p.L203L|TRPC4AP_uc002xbm.1_Silent_p.L242L	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	242	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGAAATTAGCGAGCTGCTGCT	0.438													0	0	0	0.003954	0	25	129										A	33632447	G	A	33632447	2	1	7	1	0	0	0	0	0	0	0	1	16578	1045	37	1		1	TRPC4AP	20	33632447	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	335816	33632447	29393073	538	2007										
PHF20	51230	broad.mit.edu	37	chr20	34435272	34435272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tttttttttatgttttttagGaatttcaaataaatgagcag	6	2	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:34435272G>A	uc002xek.1	+	4	367	c.256G>A	c.(256-258)GAA>AAA	p.E86K	PHF20_uc002xei.1_Missense_Mutation_p.E86K|PHF20_uc010gfo.1_Missense_Mutation_p.E86K|PHF20_uc002xej.1_5'UTR|PHF20_uc002xel.1_5'UTR	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					TGTTTTTTAGGAATTTCAAAT	0.373													0	0	0	0.010504	0	18	41										A	34435272	G	A	34435272	3	1	7	1	0	0	0	0	1	0	0	0	11831	1188	41	1	266	1	PHF20	20	34435272	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	802825	34435272	28590248	539	2008										
EPB41L1	2036	broad.mit.edu	37	chr20	34797578	34797578	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccagcatcacggtcagctctAcgtctagcctggaggctgag	12	13	4	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:34797578A>G	uc002xfb.2	+	15	2008	c.1837A>G	c.(1837-1839)ACG>GCG	p.T613A	EPB41L1_uc002xeu.2_Missense_Mutation_p.T539A|EPB41L1_uc010zvo.1_Missense_Mutation_p.T613A|EPB41L1_uc002xev.2_Missense_Mutation_p.T613A|EPB41L1_uc002xew.2_Missense_Mutation_p.T504A|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Missense_Mutation_p.T539A|EPB41L1_uc010gfq.2_Missense_Mutation_p.T712A	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	613					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GGTCAGCTCTACGTCTAGCCT	0.607													0	0	0	0.010504	0	20	24										G	34797578	A	G	34797578	3	3	7	1	0	0	0	0	1	0	0	0	5152	391	14	5	1891	5	EPB41L1	20	34797578	Missense_Mutation	SNP	A	TCGA-BT-A20J-01A-11D-A14W-08	362306	34797578	28227942	540	2009										
LBP	3929	broad.mit.edu	37	chr20	36982714	36982714	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggctcctttgatgtcagtgtCaagggcatcagcatttcggt	12	9	3	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:36982714C>G	uc002xic.1	+	4	434	c.399C>G	c.(397-399)GTC>GTG	p.V133V		NM_004139	NP_004130	P18428	LBP_HUMAN	lipopolysaccharide-binding protein precursor	133					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				ATGTCAGTGTCAAGGGCATCA	0.557													0	0	0	0.003163	0	15	121										G	36982714	C	G	36982714	2	3	7	1	0	0	0	0	0	0	0	1	8651	813	29	1		1	LBP	20	36982714	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	2185136	36982714	26042806	541	2010										
SLC32A1	140679	broad.mit.edu	37	chr20	37357141	37357141	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cccagcctctttcacctgcgCctgctctggcgcaagctgct	9	18	3	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:37357141C>G	uc002xjc.2	+	2	1700	c.1437C>G	c.(1435-1437)CGC>CGG	p.R479R		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	479	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TTCACCTGCGCCTGCTCTGGC	0.642													0	0	0	0.009096	0	4	52										G	37357141	C	G	37357141	2	3	7	1	0	0	0	0	0	0	0	1	14565	726	26	4		4	SLC32A1	20	37357141	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	374427	37357141	25668379	542	2011										
L3MBTL	26013	broad.mit.edu	37	chr20	42164893	42164893	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcagcccgcaagaagaacctCtcaggcttctccccaaggaa	8	15	3	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:42164893C>T	uc010zwh.1	+	18	2062	c.2016C>T	c.(2014-2016)CTC>CTT	p.L672L	L3MBTL_uc002xkl.2_Silent_p.L604L|L3MBTL_uc002xkm.2_Silent_p.L604L|L3MBTL_uc010ggl.2_Silent_p.L609L|L3MBTL_uc002xkn.1_Silent_p.L363L|L3MBTL_uc002xko.2_Silent_p.L256L	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	604					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AGAAGAACCTCTCAGGCTTCT	0.642													0	0	0	0.009096	0	4	15										T	42164893	C	T	42164893	2	4	7	1	0	0	0	0	0	0	0	1	8591	900	32	1		1	L3MBTL	20	42164893	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	4807752	42164893	20860627	543	2012										
HNF4A	3172	broad.mit.edu	37	chr20	43043252	43043252	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agcagctgctggttctcgttGagtgggccaagtacatccca	12	11	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:43043252G>A	uc002xma.2	+	5	687	c.598G>A	c.(598-600)GAG>AAG	p.E200K	HNF4A_uc002xlt.2_Missense_Mutation_p.E178K|HNF4A_uc002xlu.2_Missense_Mutation_p.E178K|HNF4A_uc002xlv.2_Missense_Mutation_p.E178K|HNF4A_uc002xly.2_Missense_Mutation_p.E200K|HNF4A_uc002xlz.2_Missense_Mutation_p.E200K|HNF4A_uc010ggq.2_Missense_Mutation_p.E193K	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	200					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGTTCTCGTTGAGTGGGCCAA	0.622													0	0	0	0.004482	0	8	23										A	43043252	G	A	43043252	3	1	7	1	0	0	0	0	1	0	0	0	7253	1291	45	1	669	1	HNF4A	20	43043252	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	878359	43043252	19982268	544	2013										
SULF2	55959	broad.mit.edu	37	chr20	46307544	46307544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatgttgaggacgatgtgggGattcctgggggaggcaggag	20	4	0	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:46307544G>A	uc002xto.2	-	8	1399	c.1069C>T	c.(1069-1071)CCC>TCC	p.P357S	SULF2_uc002xtr.2_Missense_Mutation_p.P357S|SULF2_uc002xtq.2_Missense_Mutation_p.P357S	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	357					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						ACGATGTGGGGATTCCTGGGG	0.617													0	0	0	0.003163	0	12	96										A	46307544	G	A	46307544	3	1	7	1	0	0	0	0	1	0	0	0	15370	1174	41	1	1599	1	SULF2	20	46307544	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3264292	46307544	16717976	545	2014										
ZNF831	128611	broad.mit.edu	37	chr20	57769685	57769685	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gcagaaggcaaaggcggcatCtgtgtacttggcggtgcact	15	9	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:57769685C>T	uc002yan.2	+	1	3611	c.3611C>T	c.(3610-3612)TCT>TTT	p.S1204F		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1204						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AAGGCGGCATCTGTGTACTTG	0.622													0	0	0	0.001368	0	13	39										T	57769685	C	T	57769685	3	4	7	1	0	0	0	0	1	0	0	0	18182	913	32	1	3613	1	ZNF831	20	57769685	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	11462141	57769685	5255835	546	2015										
CDH26	60437	broad.mit.edu	37	chr20	58558027	58558027	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aggaaaaattgtggatacatCcttgattttcaacattagga	8	5	1	1	rs149485584		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr20:58558027C>G	uc002ybe.2	+	5	743	c.443C>G	c.(442-444)TCC>TGC	p.S148C	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	148	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GTGGATACATCCTTGATTTTC	0.403													0	0	0	0.00632	0	27	156										G	58558027	C	G	58558027	3	3	7	1	0	0	0	0	1	0	0	0	3110	855	30	1	461	1	CDH26	20	58558027	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	788342	58558027	4467493	547	2016										
USP25	29761	broad.mit.edu	37	chr21	17236685	17236685	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	catgtagtggtctactttatCcagaaccaggcaccaaagaa	8	10	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:17236685C>G	uc002yjy.1	+	19	2653	c.2436C>G	c.(2434-2436)ATC>ATG	p.I812M	USP25_uc011aby.1_Missense_Mutation_p.I882M|USP25_uc002yjz.1_Missense_Mutation_p.I844M|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	812					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TCTACTTTATCCAGAACCAGG	0.348													0	0	0	0.00333	0	23	30										G	17236685	C	G	17236685	3	3	7	1	0	0	0	0	1	0	0	0	17053	845	30	1	2510	1	USP25	21	17236685	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08		17236685	30893210	548	2017										
GRIK1	2897	broad.mit.edu	37	chr21	31023467	31023467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gccatccaaaaggccagtctCgggcctgggtggggcctgca	15	13	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:31023467C>T	uc002yno.1	-	6	1389	c.925G>A	c.(925-927)GAG>AAG	p.E309K	GRIK1_uc002ynn.2_Missense_Mutation_p.E309K|GRIK1_uc011acs.1_Missense_Mutation_p.E309K|GRIK1_uc011act.1_Missense_Mutation_p.E253K|GRIK1_uc010glq.1_Missense_Mutation_p.E167K|GRIK1_uc002ynr.2_Missense_Mutation_p.E309K	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	309	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AGGCCAGTCTCGGGCCTGGGT	0.463													0	0	0	0.000602	0	5	52										T	31023467	C	T	31023467	3	4	7	1	0	0	0	0	1	0	0	0	6773	893	31	1	2039	1	GRIK1	21	31023467	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	13786782	31023467	17106428	549	2018										
KRTAP24-1	643803	broad.mit.edu	37	chr21	31655209	31655209	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctgtatgatgtggtactgcaGacaccaggatagcctgtagt	12	8	0	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:31655209G>A	uc002ynv.2	-	1	68	c.42C>T	c.(40-42)GTC>GTT	p.V14V		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	14						keratin filament	structural molecule activity				0						TGGTACTGCAGACACCAGGAT	0.493													0	0	0	0.001368	0	10	28										A	31655209	G	A	31655209	2	1	7	1	0	0	0	0	0	0	0	1	8542	929	33	1		1	KRTAP24-1	21	31655209	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	631742	31655209	16474686	550	2019										
KRTAP19-4	337971	broad.mit.edu	37	chr21	31869328	31869328	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agccacagccataacccagtCtgcggaagctgccacatcca	8	16	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:31869328C>T	uc011acz.1	-	1	101	c.101G>A	c.(100-102)AGA>AAA	p.R34K		NM_181610	NP_853641	Q3LI73	KR194_HUMAN	keratin associated protein 19-4	34						intermediate filament				ovary(2)	2						ATAACCCAGTCTGCGGAAGCT	0.527													0	0	0	0.00632	0	26	119										T	31869328	C	T	31869328	3	4	7	1	0	0	0	0	1	0	0	0	8531	913	32	1	156	1	KRTAP19-4	21	31869328	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	214119	31869328	16260567	551	2020										
TIAM1	7074	broad.mit.edu	37	chr21	32519265	32519265	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctggcgcagaaggcactgtaGagcttgaagcggtcagcata	14	9	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:32519265G>C	uc002yow.1	-	21	3895	c.3423C>G	c.(3421-3423)CTC>CTG	p.L1141L	TIAM1_uc011adk.1_Silent_p.L1141L|TIAM1_uc011adl.1_Silent_p.L1081L	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1141	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						AGGCACTGTAGAGCTTGAAGC	0.517													0	0	0	0.004482	0	7	28										C	32519265	G	C	32519265	2	2	7	1	0	0	0	0	0	0	0	1	15887	929	33	1		1	TIAM1	21	32519265	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	649937	32519265	15610630	552	2021										
SYNJ1	8867	broad.mit.edu	37	chr21	34038745	34038745	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agtgttctgtttactgacctGataaaaggagcatgctgtgg	12	6	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:34038745G>C	uc002yqh.2	-	16	2067	c.2067C>G	c.(2065-2067)ATC>ATG	p.I689M	SYNJ1_uc011ads.1_Missense_Mutation_p.I645M|SYNJ1_uc002yqf.2_Missense_Mutation_p.I650M|SYNJ1_uc002yqg.2_Missense_Mutation_p.I645M|SYNJ1_uc002yqi.2_Missense_Mutation_p.I689M	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	650	Catalytic (Potential).						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						TTACTGACCTGATAAAAGGAG	0.388													0	0	0	0.003755	0	35	208										C	34038745	G	C	34038745	3	2	7	1	0	0	0	0	1	0	0	0	15449	1280	45	1	2864	1	SYNJ1	21	34038745	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1519480	34038745	14091150	553	2022										
DOPEY2	9980	broad.mit.edu	37	chr21	37595610	37595610	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tctctaagcacagactttctCtgggattatatgacaaggtg	9	8	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:37595610C>G	uc002yvg.2	+	11	1411	c.1332C>G	c.(1330-1332)CTC>CTG	p.L444L	DOPEY2_uc011aeb.1_Silent_p.L444L	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	444					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CAGACTTTCTCTGGGATTATA	0.368													0	0	0	0.007413	0	17	91										G	37595610	C	G	37595610	2	3	7	1	0	0	0	0	0	0	0	1	4708	900	32	1		1	DOPEY2	21	37595610	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3556865	37595610	10534285	554	2023										
LRRC3	81543	broad.mit.edu	37	chr21	45876864	45876864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ccaccttcgcgggcctggccGggggcctgcggctgctggac	17	16	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:45876864G>A	uc002zfa.2	+	2	630	c.337G>A	c.(337-339)GGG>AGG	p.G113R		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	113						integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		GGGCCTGGCCGGGGGCCTGCG	0.677													0	0	0	0.00308	0	7	38										A	45876864	G	A	45876864	3	1	7	1	0	0	0	0	1	0	0	0	8984	1116	39	2	339	2	LRRC3	21	45876864	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	8281254	45876864	2253031	555	2024										
PCBP3	54039	broad.mit.edu	37	chr21	47359997	47359997	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aaaatcaatgaaattcgacaGatgtctggagctcagatcaa	8	7	4	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr21:47359997G>A	uc002zhq.1	+	13	1088	c.963G>A	c.(961-963)CAG>CAA	p.Q321Q	PCBP3_uc002zhp.1_Silent_p.Q301Q|PCBP3_uc002zhs.1_Silent_p.Q295Q|PCBP3_uc002zhr.1_Silent_p.Q320Q|PCBP3_uc002zht.1_Silent_p.Q311Q	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	321	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		AAATTCGACAGATGTCTGGAG	0.532													0	0	0	0.008291	0	10	47										A	47359997	G	A	47359997	2	1	7	1	0	0	0	0	0	0	0	1	11502	933	33	1		1	PCBP3	21	47359997	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1483133	47359997	769898	556	2025										
CABIN1	23523	broad.mit.edu	37	chr22	24468354	24468354	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gaggccaaggagccccacgtCtcttcagtgctaccctggat	11	14	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:24468354C>T	uc002zzi.1	+	18	2653	c.2526C>T	c.(2524-2526)GTC>GTT	p.V842V	CABIN1_uc002zzj.1_Silent_p.V792V|CABIN1_uc002zzl.1_Silent_p.V842V	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	842					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AGCCCCACGTCTCTTCAGTGC	0.582													0	0	0	0.00308	0	7	34										T	24468354	C	T	24468354	2	4	7	1	0	0	0	0	0	0	0	1	2528	900	32	1		1	CABIN1	22	24468354	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08		24468354	26836212	557	2026										
RFPL1	5988	broad.mit.edu	37	chr22	29835056	29835056	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cagaagaacaaaatcaggccCagttggcagctagagaggct	12	9	1	3			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:29835056C>T	uc003afn.2	+	1	485	c.276C>T	c.(274-276)CCC>CCT	p.P92P	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	92							zinc ion binding				0						AAATCAGGCCCAGTTGGCAGC	0.512													0	0	0	0.001855	0	13	61										T	29835056	C	T	29835056	2	4	7	1	0	0	0	0	0	0	0	1	13253	581	21	2		2	RFPL1	22	29835056	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	5366702	29835056	21469510	558	2027										
THOC5	8563	broad.mit.edu	37	chr22	29921847	29921847	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctgcactgatgggggtgatCagctccatggcagttgtcac	13	11	2	2	rs150202892		TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:29921847C>T	uc003afr.2	-	13	1490	c.1155G>A	c.(1153-1155)CTG>CTA	p.L385L	THOC5_uc003afq.2_Silent_p.L46L|THOC5_uc003afs.2_Silent_p.L385L|THOC5_uc003aft.2_Silent_p.L385L|THOC5_uc003afu.2_Silent_p.L385L|THOC5_uc010gvo.2_Silent_p.L129L	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	385					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						TGGGGGTGATCAGCTCCATGG	0.547													0	0	0	0.001855	0	11	52										T	29921847	C	T	29921847	2	4	7	1	0	0	0	0	0	0	0	1	15865	813	29	1		1	THOC5	22	29921847	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	86791	29921847	21382719	559	2028										
OSBP2	23762	broad.mit.edu	37	chr22	31266642	31266642	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aatgagcgggccaccctcttCcgcatcacatccaatgctat	7	15	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:31266642C>T	uc003aiy.1	+	3	1184	c.1080C>T	c.(1078-1080)TTC>TTT	p.F360F	OSBP2_uc011ala.1_Silent_p.F195F|OSBP2_uc010gwc.1_Silent_p.F187F|OSBP2_uc003aix.1_Silent_p.F360F|OSBP2_uc011alb.1_Silent_p.F360F|OSBP2_uc003aiz.1_Silent_p.F360F|OSBP2_uc003aja.1_5'UTR|OSBP2_uc011alc.1_Silent_p.F102F	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	360					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						CCACCCTCTTCCGCATCACAT	0.647													0	0	0	0.001984	0	7	24										T	31266642	C	T	31266642	2	4	7	1	0	0	0	0	0	0	0	1	11274	854	30	1		1	OSBP2	22	31266642	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1344795	31266642	20037924	560	2029										
C22orf28	51493	broad.mit.edu	37	chr22	32788307	32788307	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtctaagacatcctggaaatCtaaattacgtcgagattttg	8	7	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:32788307C>T	uc003amm.2	-	11	1461	c.1330G>A	c.(1330-1332)GAT>AAT	p.D444N		NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	444					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0						TCCTGGAAATCTAAATTACGT	0.413													0	0	0	0.004482	0	8	40										T	32788307	C	T	32788307	3	4	7	1	0	0	0	0	1	0	0	0	2140	913	32	1	195	1	C22orf28	22	32788307	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	1521665	32788307	18516259	561	2030										
TIMP3	7078	broad.mit.edu	37	chr22	33255169	33255169	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cctgttatctaattgcagatCaagtcctgctactacctgcc	6	13	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:33255169C>T	uc003anb.2	+	5	1627	c.441C>T	c.(439-441)ATC>ATT	p.I147I	SYN3_uc003amx.2_Intron|SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron	NM_000362	NP_000353	P35625	TIMP3_HUMAN	tissue inhibitor of metalloproteinase 3	147	Mediates interaction with EFEMP1.				negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			lung(1)	1						AATTGCAGATCAAGTCCTGCT	0.537													0	0	0	0.010729	0	12	37										T	33255169	C	T	33255169	2	4	7	1	0	0	0	0	0	0	0	1	15916	816	29	1		1	TIMP3	22	33255169	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	466862	33255169	18049397	562	2031										
MYH9	4627	broad.mit.edu	37	chr22	36689431	36689431	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gtgcttggcctcctcctcctCctccagctgctcccggaagg	10	18	0	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:36689431C>T	uc003apg.2	-	30	4270	c.4039G>A	c.(4039-4041)GAG>AAG	p.E1347K		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1347	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TCCTCCTCCTCCTCCAGCTGC	0.637			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.001368	0	13	43										T	36689431	C	T	36689431	3	4	7	1	0	0	0	0	1	0	0	0	10042	864	30	1	1891	1	MYH9	22	36689431	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3434262	36689431	14615135	563	2032										
POLR2F	5435	broad.mit.edu	37	chr22	38352817	38352817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ttgatgatgtggaggaggatGaagggctagatgacttggag	18	2	0	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:38352817G>A	uc003aul.2	+	2	179	c.58G>A	c.(58-60)GAA>AAA	p.E20K	POLR2F_uc010gxi.2_5'UTR|POLR2F_uc003aum.2_RNA	NM_021974	NP_068809	P61218	RPAB2_HUMAN	DNA directed RNA polymerase II polypeptide F	20					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)	1	Melanoma(58;0.045)					GGAGGAGGATGAAGGGCTAGA	0.458													0	0	0	0.00308	0	8	38										A	38352817	G	A	38352817	3	1	7	1	0	0	0	0	1	0	0	0	12219	1291	45	1	64	1	POLR2F	22	38352817	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	1663386	38352817	12951749	564	2033										
RANGAP1	5905	broad.mit.edu	37	chr22	41647082	41647082	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	atgacacctttaggaaggcaGagaccaccttctcggggtca	11	11	2	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chr22:41647082G>T	uc003azs.2	-	12	2882	c.1412C>A	c.(1411-1413)TCT>TAT	p.S471Y	RANGAP1_uc003azt.2_Missense_Mutation_p.S471Y|RANGAP1_uc003azu.2_Missense_Mutation_p.S471Y|RANGAP1_uc003azr.2_Translation_Start_Site|RANGAP1_uc010gyk.2_Translation_Start_Site|RANGAP1_uc011aoz.1_Missense_Mutation_p.S416Y	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	471					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						TAGGAAGGCAGAGACCACCTT	0.562													1	0	1.12685e-05	0.004482	1.17097e-05	9	35										T	41647082	G	T	41647082	3	4	7	1	0	0	0	0	1	0	0	0	13033	942	33	3	367	3	RANGAP1	22	41647082	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	3294265	41647082	9657484	565	2034										
PIGA	5277	broad.mit.edu	37	chrX	15349792	15349792	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	agaggcaagtaatagactttGaggccactggtgaggtaacg	14	6	0	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:15349792G>C	uc004cwr.2	-	2	361	c.261C>G	c.(259-261)CTC>CTG	p.L87L	PIGA_uc004cwq.2_5'UTR|PIGA_uc010nev.2_Silent_p.L87L|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Silent_p.L87L	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	87	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					AATAGACTTTGAGGCCACTGG	0.463													0	0	0	0.00361	0	41	42										C	15349792	G	C	15349792	2	2	7	1	0	0	0	0	0	0	0	1	11884	1277	45	1		1	PIGA	23	15349792	Silent	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08		15349792	139920768	566	2035										
BMX	660	broad.mit.edu	37	chrX	15548141	15548141	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tcacaatctgaacagttactCagacaaaaggtaaatagtct	6	8	4	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:15548141C>G	uc004cww.2	+	10	1118	c.930C>G	c.(928-930)CTC>CTG	p.L310L	BMX_uc004cwx.3_Silent_p.L310L|BMX_uc004cwy.3_Silent_p.L310L	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	310	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AACAGTTACTCAGACAAAAGG	0.368													0	0	0	0.006214	0	9	16										G	15548141	C	G	15548141	2	3	7	1	0	0	0	0	0	0	0	1	1473	813	29	1		1	BMX	23	15548141	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	198349	15548141	139722419	567	2036										
KLHL34	257240	broad.mit.edu	37	chrX	21675005	21675005	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ggcccctagctgccctctgcGgggccgcgacctcctcaatc	11	19	2	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:21675005G>A	uc004czz.1	-	1	1444	c.902C>T	c.(901-903)CCG>CTG	p.P301L		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	301										ovary(1)	1						TGCCCTCTGCGGGGCCGCGAC	0.557													0	0	0	0.001168	0	6	6										A	21675005	G	A	21675005	3	1	7	1	0	0	0	0	1	0	0	0	8387	1116	39	2	1036	2	KLHL34	23	21675005	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	6126864	21675005	133595555	568	2037										
POLA1	5422	broad.mit.edu	37	chrX	24906201	24906201	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	aattctcccgaactgggcctCtttgcccagcctgcatgaaa	8	14	2	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:24906201C>G	uc004dbl.2	+	35	4131	c.4108C>G	c.(4108-4110)CTT>GTT	p.L1370V		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	1370	Potential.|C4-type.				cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	AACTGGGCCTCTTTGCCCAGC	0.493													0	0	0	0.001368	0	12	17										G	24906201	C	G	24906201	3	3	7	1	0	0	0	0	1	0	0	0	12187	913	32	1	4246	1	POLA1	23	24906201	Missense_Mutation	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	3231196	24906201	130364359	569	2038										
IL1RAPL1	11141	broad.mit.edu	37	chrX	29935671	29935671	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	gatgaaaggagaaaaatttaTtgaagatctggatgaaaatc	10	2	1	5			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:29935671T>C	uc004dby.2	+	7	1377	c.869T>C	c.(868-870)ATT>ACT	p.I290T		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	290	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GAAAAATTTATTGAAGATCTG	0.363													0	0	0	0.012319	0	19	14										C	29935671	T	C	29935671	3	2	7	1	0	0	0	0	1	0	0	0	7661	1493	52	5	891	5	IL1RAPL1	23	29935671	Missense_Mutation	SNP	T	TCGA-BT-A20J-01A-11D-A14W-08	5029470	29935671	125334889	570	2039										
UBA1	7317	broad.mit.edu	37	chrX	47069375	47069375	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cggctggcaggcactcagccCttggaggtgctggaggctgt	17	11	1	0			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:47069375C>T	uc004dhj.3	+	18	2203	c.2052C>T	c.(2050-2052)CCC>CCT	p.P684P	UBA1_uc004dhk.3_Silent_p.P684P|UBA1_uc004dhm.2_Silent_p.P132P	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	684					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						GCACTCAGCCCTTGGAGGTGC	0.607													0	0	0	0.008291	0	10	64										T	47069375	C	T	47069375	2	4	7	1	0	0	0	0	0	0	0	1	16824	668	24	2		2	UBA1	23	47069375	Silent	SNP	C	TCGA-BT-A20J-01A-11D-A14W-08	17133704	47069375	108201185	571	2040										
PLP2	5355	broad.mit.edu	37	chrX	49030735	49030736	+	Missense_Mutation	DNP	CC	CC	TT													0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	tatgatgcctatgtcaccttCcccgttcggcagccaagaca							TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:49030735_49030736CC>TT	uc004dmx.2	+	4	474_475	c.399_400CC>TT	c.(397-402)TTCCCC>TTTTCC	p.P134S		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	134	MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						ATGTCACCTTCCCCGTTCGGCA	0.559													0	0	0	0.004672	0	17	15										TT	49030736	CC	TT	49030735	3	4	7	1	0	0	0	0	1	0	0	0	12105	854	30	1	413	1	PLP2	23	49030735	Missense_Mutation	DNP	CC	TCGA-BT-A20J-01A-11D-A14W-08	1961360	49030735	106239825	572	2041										
OTUD6A	139562	broad.mit.edu	37	chrX	69282886	69282886	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	cgtgtctgtggagatgctgcGctgccgcaccgccagctaca	13	14	1	1			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:69282886G>C	uc004dxu.1	+	1	546	c.512G>C	c.(511-513)CGC>CCC	p.R171P		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	171	OTU.									lung(1)|skin(1)	2						GAGATGCTGCGCTGCCGCACC	0.617													0	0	0	0.001168	0	5	8										C	69282886	G	C	69282886	3	2	7	1	0	0	0	0	1	0	0	0	11316	1087	38	4	514	4	OTUD6A	23	69282886	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	20252151	69282886	85987674	573	2042										
ATP7A	538	broad.mit.edu	37	chrX	77245376	77245376	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	caaatagcaatgggactgttGagtatgatcctctactaacc	8	9	1	2			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:77245376G>C	uc004ecx.3	+	4	1418	c.1258G>C	c.(1258-1260)GAG>CAG	p.E420Q	ATP7A_uc004ecw.2_Missense_Mutation_p.E420Q	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	420	HMA 4.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TGGGACTGTTGAGTATGATCC	0.403													0	0	0	0.001168	0	6	66										C	77245376	G	C	77245376	3	2	7	1	0	0	0	0	1	0	0	0	1190	1291	45	1	1268	1	ATP7A	23	77245376	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	7962490	77245376	78025184	574	2043										
TBC1D8B	54885	broad.mit.edu	37	chrX	106083998	106083998	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548161120840631	313	7.64666025559008e-114	3.96570881308605	5.34610171652526	3.08807882016463	0.27576241211135	0.465572903564617	234	ctactgaagaaattgaacgtGatttacgtcgctctctgcct	8	10	1	4			TCGA-BT-A20J-01A-11D-A14W-08	TCGA-BT-A20J-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d3c0ff9-d149-4d21-8955-5fb849fc5462	a1378c67-a8c5-4591-9564-22bc71cbe0b8	g.chrX:106083998G>C	uc004emo.2	+	10	1768	c.1603G>C	c.(1603-1605)GAT>CAT	p.D535H	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Missense_Mutation_p.D535H	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	535	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AATTGAACGTGATTTACGTCG	0.463													0	0	0	0.001855	0	12	56										C	106083998	G	C	106083998	3	2	7	1	0	0	0	0	1	0	0	0	15623	1290	45	1	1641	1	TBC1D8B	23	106083998	Missense_Mutation	SNP	G	TCGA-BT-A20J-01A-11D-A14W-08	28838622	106083998	49186562	575	2044										
KLHL17	339451	broad.mit.edu	37	chr1	900368	900368	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgcatgacctggtggccatgGacggatggttgtacgccgtg	16	10	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:900368G>T	uc001aca.1	+	12	1833	c.1726G>T	c.(1726-1728)GAC>TAC	p.D576Y	KLHL17_uc001acc.1_RNA|PLEKHN1_uc001acd.2_5'Flank|PLEKHN1_uc001acf.2_5'Flank|PLEKHN1_uc001ace.2_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	576	Interaction with F-actin (By similarity).|Kelch 5.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGTGGCCATGGACGGATGGTT	0.647													1	0	0.000151284	0.001855	0.000160839	14	10										T	900368	G	T	900368	3	4	8	1	0	0	0	0	1	0	0	0	8372	1174	41	3	1772	3	KLHL17	1	900368	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		900368	248350253	1	2045										
PRDM16	63976	broad.mit.edu	37	chr1	3328010	3328010	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gccggcacaagcggatgcacGccgactgccgcacgcagatc	13	16	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:3328010G>A	uc001akf.2	+	9	1329	c.1249G>A	c.(1249-1251)GCC>ACC	p.A417T	PRDM16_uc001akc.2_Missense_Mutation_p.A417T|PRDM16_uc001akd.2_Missense_Mutation_p.A417T|PRDM16_uc001ake.2_Missense_Mutation_p.A417T|PRDM16_uc009vlh.2_Missense_Mutation_p.A118T	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	417					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCGGATGCACGCCGACTGCCG	0.572			T	EVI1	MDS|AML								0	0	0	0.004482	0	9	30										A	3328010	G	A	3328010	3	1	8	1	0	0	0	0	1	0	0	0	12457	1087	38	2	1283	2	PRDM16	1	3328010	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2427642	3328010	245922611	2	2046										
MASP2	10747	broad.mit.edu	37	chr1	11102931	11102931	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atctgagacccacttgctcaCctgtgctcgtgtagtggatc	10	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:11102931C>T	uc001aru.2	-	6	910	c.889_splice	c.e6+1	p.A297_splice		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform						complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CACTTGCTCACCTGTGCTCGT	0.547													0	0	0	0.00632	0	25	92										T	11102931	C	T	11102931	5	4	8	1	0	0	0	0	0	0	1	0	9323	521	18	2	1194	2	MASP2	1	11102931	Splice_Site	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	7774921	11102931	238147690	3	2047										
C1orf158	93190	broad.mit.edu	37	chr1	12819302	12819302	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cccccacatcgctacctgatCagcacctatgacgaccatta	5	17	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:12819302C>G	uc001auh.2	+	3	501	c.285C>G	c.(283-285)ATC>ATG	p.I95M	C1orf158_uc010obe.1_Missense_Mutation_p.I95M	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	95										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GCTACCTGATCAGCACCTATG	0.567													0	0	0	0.01441	0	54	178										G	12819302	C	G	12819302	3	3	8	1	0	0	0	0	1	0	0	0	2007	816	29	1	295	1	C1orf158	1	12819302	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1716371	12819302	236431319	4	2048										
C1orf158	93190	broad.mit.edu	37	chr1	12820737	12820737	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tatggactctatgagcagctCaagcagagacagctcacacc	9	12	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:12820737C>G	uc001auh.2	+	4	654	c.438C>G	c.(436-438)CTC>CTG	p.L146L		NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	146										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ATGAGCAGCTCAAGCAGAGAC	0.527													0	0	0	0.013537	0	12	57										G	12820737	C	G	12820737	2	3	8	1	0	0	0	0	0	0	0	1	2007	813	29	1		1	C1orf158	1	12820737	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1435	12820737	236429884	5	2049										
PRAMEF11	440560	broad.mit.edu	37	chr1	12887575	12887575	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atccttggacagtcctgcacTggtgttttgttcctcttggc	10	11	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:12887575T>A	uc001auk.2	-	3	478	c.282A>T	c.(280-282)CCA>CCT	p.P94P		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	94											0						AGTCCTGCACTGGTGTTTTGT	0.498													0	0	0	0.007413	0	17	265										A	12887575	T	A	12887575	2	1	8	1	0	0	0	0	0	0	0	1	12427	1567	55	5		5	PRAMEF11	1	12887575	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	66838	12887575	236363046	6	2050										
CLCNKB	1188	broad.mit.edu	37	chr1	16372138	16372138	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctcggggtgctcatggccctGgtcagctgtgccatggactt	14	12	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:16372138G>C	uc001axw.3	+	3	266	c.186G>C	c.(184-186)CTG>CTC	p.L62L	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.L62L	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	62	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCATGGCCCTGGTCAGCTGTG	0.627													0	0	0	0.007413	0	17	43										C	16372138	G	C	16372138	2	2	8	1	0	0	0	0	0	0	0	1	3470	1335	47	4		4	CLCNKB	1	16372138	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	3484563	16372138	232878483	7	2051										
NBPF1	55672	broad.mit.edu	37	chr1	16895671	16895671	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcaggaggaattgagagagtCgaataaccttcatcccagga	11	8	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:16895671C>T	uc009vos.1	-	23	3399	c.2511G>A	c.(2509-2511)TCG>TCA	p.S837S	NBPF1_uc009vot.1_Silent_p.S295S|NBPF1_uc001ayz.1_Silent_p.S295S|NBPF1_uc010oce.1_Silent_p.S566S	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	837	NBPF 4.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TTGAGAGAGTCGAATAACCTT	0.488													0	0	0	0.01441	0	49	302										T	16895671	C	T	16895671	2	4	8	1	0	0	0	0	0	0	0	1	10192	871	31	1		1	NBPF1	1	16895671	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	523533	16895671	232354950	8	2052										
UBR4	23352	broad.mit.edu	37	chr1	19491386	19491386	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagaatcttttgggggcgatGtagtcatgcgggtgagccag	16	7	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:19491386G>C	uc001bbi.2	-	32	4422	c.4418C>G	c.(4417-4419)ACA>AGA	p.T1473R	UBR4_uc001bbm.1_Missense_Mutation_p.T684R	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1473					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGGGGCGATGTAGTCATGCG	0.552													0	0	0	0.009096	0	4	73										C	19491386	G	C	19491386	3	2	8	1	0	0	0	0	1	0	0	0	16901	1377	48	4	11433	4	UBR4	1	19491386	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2595715	19491386	229759235	9	2053										
EPHB2	2048	broad.mit.edu	37	chr1	23236885	23236885	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	attgtcccaggtaatcaatgCcattgagcaggactatcggc	10	10	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:23236885C>G	uc009vqj.1	+	14	2658	c.2513C>G	c.(2512-2514)GCC>GGC	p.A838G	EPHB2_uc001bge.2_Missense_Mutation_p.A839G|EPHB2_uc001bgf.2_Missense_Mutation_p.A838G|EPHB2_uc010odu.1_Missense_Mutation_p.A780G	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	838	Cytoplasmic (Potential).|Protein kinase.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GTAATCAATGCCATTGAGCAG	0.617									Hereditary_Prostate_Cancer				0	0	0	0.009096	0	4	57										G	23236885	C	G	23236885	3	3	8	1	0	0	0	0	1	0	0	0	5175	739	26	4	2570	4	EPHB2	1	23236885	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3745499	23236885	226013736	10	2054										
MYOM3	127294	broad.mit.edu	37	chr1	24397687	24397687	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cttttctacttccagccaaaGccgcacctcccctcgctcca	4	20	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:24397687G>C	uc001bin.3	-	25	3233	c.3070C>G	c.(3070-3072)CTT>GTT	p.L1024V	MYOM3_uc001bim.3_Missense_Mutation_p.L681V|MYOM3_uc001bio.2_Missense_Mutation_p.L1024V	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1024										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TCCAGCCAAAGCCGCACCTCC	0.547											OREG0013235	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	20										C	24397687	G	C	24397687	3	2	8	1	0	0	0	0	1	0	0	0	10093	971	34	4	1295	4	MYOM3	1	24397687	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1160802	24397687	224852934	11	2055										
LDLRAP1	26119	broad.mit.edu	37	chr1	25891685	25891685	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agctggatgatggcctggatGaagcgttttcgaggtaatgc	15	6	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:25891685G>A	uc001bkl.3	+	8	883	c.769G>A	c.(769-771)GAA>AAA	p.E257K	LDLRAP1_uc009vrw.2_RNA|LDLRAP1_uc009vrx.2_Missense_Mutation_p.E87K	NM_015627	NP_056442	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein	257	AP-2 complex binding.|[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCCTGGATGAAGCGTTTTC	0.587													0	0	0	0.01441	0	56	55										A	25891685	G	A	25891685	3	1	8	1	0	0	0	0	1	0	0	0	8708	1291	45	1	799	1	LDLRAP1	1	25891685	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1493998	25891685	223358936	12	2056										
EIF3I	8668	broad.mit.edu	37	chr1	32688180	32688180	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	catgagcggtccattacgcaGattaagtataaccgcgaagg	11	9	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:32688180G>C	uc001bur.3	+	3	578	c.45G>C	c.(43-45)CAG>CAC	p.Q15H	C1orf91_uc001buo.3_5'Flank|C1orf91_uc001bup.3_5'Flank|C1orf91_uc009vub.1_5'Flank|C1orf91_uc010oha.1_5'Flank|C1orf91_uc001buq.3_5'Flank|EIF3I_uc009vuc.2_Missense_Mutation_p.Q15H|EIF3I_uc001bus.2_5'UTR	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	15	WD 1.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				CCATTACGCAGATTAAGTATA	0.597													0	0	0	0.00333	0	22	72										C	32688180	G	C	32688180	3	2	8	1	0	0	0	0	1	0	0	0	5019	933	33	1	51	1	EIF3I	1	32688180	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6796495	32688180	216562441	13	2057										
DLGAP3	58512	broad.mit.edu	37	chr1	35370070	35370070	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcggccttccgacccgccCgagcgccccttgaagctcaa	10	19	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:35370070C>G	uc001byc.2	-	1	915	c.915G>C	c.(913-915)TCG>TCC	p.S305S		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	305					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCGACCCGCCCGAGCGCCCCT	0.657													0	0	0	0.00333	0	25	29										G	35370070	C	G	35370070	2	3	8	1	0	0	0	0	0	0	0	1	4561	639	23	4		4	DLGAP3	1	35370070	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2681890	35370070	213880551	14	2058										
TIE1	7075	broad.mit.edu	37	chr1	43774766	43774766	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cccttccccgtgcggggcagCatagagctacgcaagccaga	12	15	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:43774766C>T	uc001ciu.2	+	8	1231	c.1152C>T	c.(1150-1152)AGC>AGT	p.S384S	TIE1_uc010okd.1_Silent_p.S384S|TIE1_uc010oke.1_Silent_p.S339S|TIE1_uc009vwq.2_Silent_p.S340S|TIE1_uc010okf.1_Silent_p.S29S|TIE1_uc010okg.1_Silent_p.S29S|TIE1_uc010okc.1_Intron	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	384	Ig-like C2-type 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCGGGGCAGCATAGAGCTAC	0.612													0	0	0	0.00245	0	11	21										T	43774766	C	T	43774766	2	4	8	1	0	0	0	0	0	0	0	1	15890	709	25	2		2	TIE1	1	43774766	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	8404696	43774766	205475855	15	2059										
KIF2C	11004	broad.mit.edu	37	chr1	45205650	45205650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cccgcctgtttcccggtctcGctatcaagatccaacgcagt	8	16	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:45205650G>A	uc001cmg.3	+	1	161	c.46G>A	c.(46-48)GCT>ACT	p.A16T	KIF2C_uc010olb.1_Missense_Mutation_p.A16T	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	16	Globular (Potential).				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TCCCGGTCTCGCTATCAAGAT	0.567													0	0	0	0.01441	0	54	319										A	45205650	G	A	45205650	3	1	8	1	0	0	0	0	1	0	0	0	8299	1087	38	2	48	2	KIF2C	1	45205650	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1430884	45205650	204044971	16	2060										
EPS15	2060	broad.mit.edu	37	chr1	51929378	51929378	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tccacaggtaacttagagttGagcaacactggtttcacttt	8	9	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:51929378G>A	uc001csq.1	-	7	560	c.468C>T	c.(466-468)CTC>CTT	p.L156L	EPS15_uc009vyz.1_Silent_p.L156L	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	156	EH 2.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						ACTTAGAGTTGAGCAACACTG	0.328			T	MLL	ALL								0	0	0	0.000602	0	5	40										A	51929378	G	A	51929378	2	1	8	1	0	0	0	0	0	0	0	1	5192	1277	45	1		1	EPS15	1	51929378	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6723728	51929378	197321243	17	2061										
EPS15	2060	broad.mit.edu	37	chr1	51934235	51934235	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acaagacgcaaagcaacaaaGaattcctaagaaagaaaagt	7	7	0	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:51934235G>C	uc001csq.1	-	5	311	c.219C>G	c.(217-219)TTC>TTG	p.F73L	EPS15_uc009vyz.1_Missense_Mutation_p.F73L	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	73	EH 1.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						AAGCAACAAAGAATTCCTAAG	0.368			T	MLL	ALL								0	0	0	0.006214	0	6	21										C	51934235	G	C	51934235	3	2	8	1	0	0	0	0	1	0	0	0	5192	933	33	1	2653	1	EPS15	1	51934235	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	4857	51934235	197316386	18	2062										
GLIS1	148979	broad.mit.edu	37	chr1	54060429	54060429	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgggtctcgggctggaggccCaggccagagctgggttcgct	18	11	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:54060429C>A	uc001cvr.1	-	3	714	c.147G>T	c.(145-147)CTG>CTT	p.L49L		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	49					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GCTGGAGGCCCAGGCCAGAGC	0.711													1	0	0.00909568	0.009096	0.00939809	4	18										A	54060429	C	A	54060429	2	1	8	1	0	0	0	0	0	0	0	1	6445	581	21	4		4	GLIS1	1	54060429	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2126194	54060429	195190192	19	2063										
WLS	79971	broad.mit.edu	37	chr1	68620905	68620905	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccaatttccatgaaaggaagGacatcacattcatagtaacg	7	9	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:68620905G>A	uc001def.1	-	4	814	c.543C>T	c.(541-543)GTC>GTT	p.V181V	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Silent_p.V179V|WLS_uc001deg.1_Silent_p.V90V|WLS_uc009wbf.1_Silent_p.V136V	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	181	Lumenal (Potential).|Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						TGAAAGGAAGGACATCACATT	0.453													0	0	0	0.005524	0	38	40										A	68620905	G	A	68620905	2	1	8	1	0	0	0	0	0	0	0	1	17373	1161	41	1		1	WLS	1	68620905	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	14560476	68620905	180629716	20	2064										
TTLL7	79739	broad.mit.edu	37	chr1	84387005	84387005	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctggtaagagccttttaatTgaattttgaccatagagcct	8	8	0	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:84387005T>G	uc001djc.2	-	11	1611	c.1215A>C	c.(1213-1215)TCA>TCC	p.S405S	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	405					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GCCTTTTAATTGAATTTTGAC	0.413													0	0	0	0.00499	0	17	63										G	84387005	T	G	84387005	2	3	8	1	0	0	0	0	0	0	0	1	16729	1799	63	5		5	TTLL7	1	84387005	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	15766100	84387005	164863616	21	2065										
BRDT	676	broad.mit.edu	37	chr1	92446894	92446894	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggaattggaaaagcggttacTggatgttaataatcagttaa	11	3	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:92446894T>G	uc001dok.3	+	11	2169	c.1820T>G	c.(1819-1821)CTG>CGG	p.L607R	BRDT_uc001dol.3_Missense_Mutation_p.L607R|BRDT_uc010osz.1_Missense_Mutation_p.L611R|BRDT_uc009wdf.2_Missense_Mutation_p.L534R|BRDT_uc010ota.1_Missense_Mutation_p.L561R|BRDT_uc010otb.1_Missense_Mutation_p.L561R|BRDT_uc001dom.3_Missense_Mutation_p.L607R	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	607	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AAGCGGTTACTGGATGTTAAT	0.274													0	0	0	0.006214	0	9	42										G	92446894	T	G	92446894	3	3	8	1	0	0	0	0	1	0	0	0	1508	1580	55	5	1858	5	BRDT	1	92446894	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	8059889	92446894	156803727	22	2066										
AMIGO1	57463	broad.mit.edu	37	chr1	110050899	110050899	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtaggtacagcccattcttGatccaggccggcagcttctg	11	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:110050899G>C	uc001dxx.3	-	2	1018	c.636C>G	c.(634-636)ATC>ATG	p.I212M		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	212	Extracellular (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		GCCCATTCTTGATCCAGGCCG	0.532													0	0	0	0.01441	0	52	28										C	110050899	G	C	110050899	3	2	8	1	0	0	0	0	1	0	0	0	575	1280	45	1	849	1	AMIGO1	1	110050899	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	17604005	110050899	139199722	23	2067										
ST7L	54879	broad.mit.edu	37	chr1	113161719	113161720	+	Missense_Mutation	DNP	CC	CC	AG													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagctgcggcttcacccacgCcgccacggtccgccatcttg							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:113161719_113161720CC>AG	uc001ecd.2	-	1	321_322	c.16_17GG>CT	c.(16-18)GGC>CTC	p.G6L	ST7L_uc001ecc.2_5'Flank|ST7L_uc010owg.1_Missense_Mutation_p.G6L|ST7L_uc010owh.1_Missense_Mutation_p.G6L|ST7L_uc001ece.2_Missense_Mutation_p.G6L|ST7L_uc001ecf.2_Missense_Mutation_p.G6L|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_5'Flank|ST7L_uc001ech.2_Missense_Mutation_p.G6L|ST7L_uc001eci.2_Missense_Mutation_p.G6L|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Missense_Mutation_p.G6L|CAPZA1_uc001ecj.1_5'Flank	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	6					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCACCCACGCCGCCACGGTCC	0.683													0	0	0	0.004672	0	8	5										AG	113161720	CC	AG	113161719	3	1	8	1	0	0	0	0	1	0	0	0	15229	739	26	4	1809	4	ST7L	1	113161719	Missense_Mutation	DNP	CC	TCGA-BT-A20N-01A-11D-A14W-08	3110820	113161719	136088902	24	2068										
MTMR11	10903	broad.mit.edu	37	chr1	149903256	149903256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gccaaacagtgttcgggcttCgggggctgaaagcagctgga	16	9	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:149903256C>T	uc001etl.3	-	13	1437	c.1186G>A	c.(1186-1188)GAA>AAA	p.E396K	MTMR11_uc001etm.1_Missense_Mutation_p.E324K|MTMR11_uc010pbm.1_Intron|MTMR11_uc010pbn.1_Missense_Mutation_p.R222Q	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	396	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GTTCGGGCTTCGGGGGCTGAA	0.572													0	0	0	0.005443	0	27	55										T	149903256	C	T	149903256	3	4	8	1	0	0	0	0	1	0	0	0	9940	893	31	1	1002	1	MTMR11	1	149903256	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	36741537	149903256	99347365	25	2069										
TCHH	7062	broad.mit.edu	37	chr1	152081550	152081550	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgttcctggcggcgcagccgCtgttcctcctcgaggaattt	12	14	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:152081550C>G	uc001ezp.2	-	2	4143	c.4143G>C	c.(4141-4143)CAG>CAC	p.Q1381H	TCHH_uc009wne.1_Missense_Mutation_p.Q1381H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1381	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCGCAGCCGCTGTTCCTCCT	0.602													0	0	0	0.008871	0	21	242										G	152081550	C	G	152081550	3	3	8	1	0	0	0	0	1	0	0	0	15697	796	28	4	1692	4	TCHH	1	152081550	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2178294	152081550	97169071	26	2070										
HRNR	388697	broad.mit.edu	37	chr1	152193791	152193791	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gttcctcttggtgctggtgaGtgtcatctctcagctttgac	11	10	4	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:152193791G>T	uc001ezt.1	-	3	390	c.314C>A	c.(313-315)ACT>AAT	p.T105N		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	105	1.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCTGGTGAGTGTCATCTCT	0.413													1	0	7.48243e-07	0.006214	8.32755e-07	10	124										T	152193791	G	T	152193791	3	4	8	1	0	0	0	0	1	0	0	0	7359	1029	36	4	8242	4	HRNR	1	152193791	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	112241	152193791	97056830	27	2071										
FLG	2312	broad.mit.edu	37	chr1	152285219	152285220	+	Missense_Mutation	DNP	GG	GG	CT													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tctggagctgtctgctgactGgagctggtggcgggatccat							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:152285219_152285220GG>CT	uc001ezu.1	-	3	2178_2179	c.2142_2143CC>AG	c.(2140-2145)CTCCAG>CTAGAG	p.Q715E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	715	Filaggrin 4.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGCTGACTGGAGCTGGTGGC	0.569									Ichthyosis				0	0	0	0.004672	0	526	360										CT	152285220	GG	CT	152285219	3	2	8	1	0	0	0	0	1	0	0	0	5922	1357	47	4	10046	4	FLG	1	152285219	Missense_Mutation	DNP	GG	TCGA-BT-A20N-01A-11D-A14W-08	91428	152285219	96965402	28	2072										
FLG2	388698	broad.mit.edu	37	chr1	152327473	152327473	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaccatagccagatgactgaCttgagccagaaccatgttgg	11	10	0	5			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:152327473C>T	uc001ezw.3	-	3	2862	c.2789G>A	c.(2788-2790)AGT>AAT	p.S930N	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	930	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGATGACTGACTTGAGCCAGA	0.478													0	0	0	0.004289	0	33	473										T	152327473	C	T	152327473	3	4	8	1	0	0	0	0	1	0	0	0	5923	565	20	2	4390	2	FLG2	1	152327473	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	42254	152327473	96923148	29	2073										
LCE1C	353133	broad.mit.edu	37	chr1	152777745	152777745	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aggcagcagccacctcccccAgaactgcagcatcccccaga	8	19	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:152777745A>T	uc001fap.1	-	2	261	c.210T>A	c.(208-210)TCT>TCA	p.S70S		NM_178351	NP_848128	Q5T751	LCE1C_HUMAN	late cornified envelope 1C	70	Gly-rich.				keratinization						0	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACCTCCCCCAGAACTGCAGC	0.682													0	0	0	0.013537	0	12	142										T	152777745	A	T	152777745	2	4	8	1	0	0	0	0	0	0	0	1	8661	175	7	5		5	LCE1C	1	152777745	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	450272	152777745	96472876	30	2074										
NUP210L	91181	broad.mit.edu	37	chr1	154018563	154018563	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acctctgaatgcctgggcacTagatccaatacatccctttt	6	13	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:154018563T>G	uc001fdw.2	-	27	3750	c.3678A>C	c.(3676-3678)CTA>CTC	p.L1226L	NUP210L_uc009woq.2_Silent_p.L135L|NUP210L_uc010peh.1_Silent_p.L1226L	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1226						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			GCCTGGGCACTAGATCCAATA	0.373													0	0	0	0.009096	0	4	81										G	154018563	T	G	154018563	2	3	8	1	0	0	0	0	0	0	0	1	10761	1509	53	5		5	NUP210L	1	154018563	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	1240818	154018563	95232058	31	2075										
TPM3	7170	broad.mit.edu	37	chr1	154130139	154130139	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atctcattcaggtcaagcagGgtctggtccagcatcctttg	10	11	4	0	rs1051220		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:154130139G>C	uc001fdy.1	-	8	853	c.723C>G	c.(721-723)ACC>ACG	p.T241T	TPM3_uc001fdx.1_Silent_p.T226T|TPM3_uc010pei.1_Silent_p.T151T|TPM3_uc001fdz.1_3'UTR|TPM3_uc001fea.1_Silent_p.T241T|TPM3_uc001feb.1_3'UTR|TPM3_uc010pej.1_Silent_p.T174T|TPM3_uc009wor.2_Intron|NUP210L_uc001fdw.2_5'Flank|NUP210L_uc010peh.1_5'Flank	NM_001043351	NP_001036816	P06753	TPM3_HUMAN	tropomyosin 3 isoform 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/ALK(33)	haematopoietic_and_lymphoid_tissue(22)|soft_tissue(11)|skin(1)	34	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					GGTCAAGCAGGGTCTGGTCCA	0.532			T	NTRK1|ALK	papillary thyroid|ALCL								0	0	0	0.006122	0	18	217										C	154130139	G	C	154130139	2	2	8	1	0	0	0	0	0	0	0	1	16404	1219	43	4		4	TPM3	1	154130139	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	111576	154130139	95120482	32	2076										
CHRNB2	1141	broad.mit.edu	37	chr1	154542804	154542804	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaagaaagttcggctcccttCcaaacacatctggctcccag	8	14	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:154542804C>G	uc001ffg.2	+	4	590	c.326C>G	c.(325-327)TCC>TGC	p.S109C		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	109	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	CGGCTCCCTTCCAAACACATC	0.532													0	0	0	0.004672	0	3	23										G	154542804	C	G	154542804	3	3	8	1	0	0	0	0	1	0	0	0	3391	855	30	1	340	1	CHRNB2	1	154542804	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	412665	154542804	94707817	33	2077										
CHRNB2	1141	broad.mit.edu	37	chr1	154544007	154544007	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	attcgccgcaagccgctcttCtacaccatcaacctcatcat	4	17	5	0	rs71628622		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:154544007C>G	uc001ffg.2	+	5	972	c.708C>G	c.(706-708)TTC>TTG	p.F236L		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	236	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	AGCCGCTCTTCTACACCATCA	0.577													0	0	0	0.013537	0	10	130										G	154544007	C	G	154544007	3	3	8	1	0	0	0	0	1	0	0	0	3391	912	32	1	726	1	CHRNB2	1	154544007	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1203	154544007	94706614	34	2078										
CHRNB2	1141	broad.mit.edu	37	chr1	154544202	154544202	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccgctcgtcggcaagtacctCatgttcaccatggtgcttgt	10	13	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:154544202C>T	uc001ffg.2	+	5	1167	c.903C>T	c.(901-903)CTC>CTT	p.L301L		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	301	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GCAAGTACCTCATGTTCACCA	0.627													0	0	0	0.00308	0	8	102										T	154544202	C	T	154544202	2	4	8	1	0	0	0	0	0	0	0	1	3391	813	29	1		1	CHRNB2	1	154544202	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	195	154544202	94706419	35	2079										
GBA	2629	broad.mit.edu	37	chr1	155207267	155207267	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgatgttcaggggtgaagccCaggcactggaaggggtatcc	16	8	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:155207267C>A	uc001fjh.2	-	7	1014	c.864G>T	c.(862-864)CTG>CTT	p.L288L	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Silent_p.L175L|GBA_uc010pfx.1_Silent_p.L239L|GBA_uc001fji.2_Silent_p.L288L|GBA_uc001fjj.2_Silent_p.L288L|GBA_uc001fjk.2_Silent_p.L288L|GBA_uc001fjl.2_Silent_p.L288L|GBA_uc010pfy.1_Silent_p.L201L|GBA_uc009wqk.1_Silent_p.L201L	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	288					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	GGGTGAAGCCCAGGCACTGGA	0.547									Gaucher_disease_type_I				1	0	1.60099e-16	0.004878	1.92499e-16	34	23										A	155207267	C	A	155207267	2	1	8	1	0	0	0	0	0	0	0	1	6266	581	21	4		4	GBA	1	155207267	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	663065	155207267	94043354	36	2080										
GBA	2629	broad.mit.edu	37	chr1	155209446	155209446	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttaagtagcaaattttgggCagggggtgacagggcaagga	16	4	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:155209446C>A	uc001fjh.2	-	4	565	c.415G>T	c.(415-417)GCC>TCC	p.A139S	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Intron|GBA_uc010pfx.1_Intron|GBA_uc001fji.2_Missense_Mutation_p.A139S|GBA_uc001fjj.2_Missense_Mutation_p.A139S|GBA_uc001fjk.2_Missense_Mutation_p.A139S|GBA_uc001fjl.2_Missense_Mutation_p.A139S|GBA_uc010pfy.1_Missense_Mutation_p.A52S|GBA_uc009wqk.1_Missense_Mutation_p.A52S	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	139					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	AAATTTTGGGCAGGGGGTGAC	0.448									Gaucher_disease_type_I				1	0	1.37522e-17	0.007413	1.66344e-17	16	46										A	155209446	C	A	155209446	3	1	8	1	0	0	0	0	1	0	0	0	6266	710	25	4	1227	4	GBA	1	155209446	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2179	155209446	94041175	37	2081										
INSRR	3645	broad.mit.edu	37	chr1	156823630	156823630	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agggctcaccagcagcacccAgcacaccagggcacacgtca	10	17	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:156823630A>G	uc010pht.1	-	2	805	c.551T>C	c.(550-552)CTG>CCG	p.L184P	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.L184P	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	184					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGCAGCACCCAGCACACCAGG	0.637													0	0	0	0.001168	0	6	57										G	156823630	A	G	156823630	3	3	8	1	0	0	0	0	1	0	0	0	7774	188	7	5	3425	5	INSRR	1	156823630	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	1614184	156823630	92426991	38	2082										
NTRK1	4914	broad.mit.edu	37	chr1	156845891	156845892	+	Missense_Mutation	DNP	CC	CC	AT													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggtgttcaccacatcaagcgCcgggacatcgtgctcaagtg							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:156845891_156845892CC>AT	uc001fqh.1	+	13	1577_1578	c.1521_1522CC>AT	c.(1519-1524)CGCCGG>CGATGG	p.R508W	NTRK1_uc001fqf.1_Missense_Mutation_p.R472W|NTRK1_uc009wsi.1_Missense_Mutation_p.R207W|NTRK1_uc001fqi.1_Missense_Mutation_p.R502W|NTRK1_uc009wsk.1_Missense_Mutation_p.R505W	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	508	Cytoplasmic (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	ACATCAAGCGCCGGGACATCGT	0.609			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			0	0	0	0.004672	0	11	116										AT	156845892	CC	AT	156845891	3	1	8	1	0	0	0	0	1	0	0	0	10706	726	26	4	1701	4	NTRK1	1	156845891	Missense_Mutation	DNP	CC	TCGA-BT-A20N-01A-11D-A14W-08	22261	156845891	92404730	39	2083										
CD5L	922	broad.mit.edu	37	chr1	157805906	157805906	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctccacccgcccttcacagCggtggaggccccccaccagc	9	22	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:157805906C>T	uc001frk.3	-	3	238	c.95G>A	c.(94-96)CGC>CAC	p.R32H		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	32	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCCTTCACAGCGGTGGAGGCC	0.622													0	0	0	0.004482	0	9	107										T	157805906	C	T	157805906	3	4	8	1	0	0	0	0	1	0	0	0	3027	768	27	2	964	2	CD5L	1	157805906	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	960015	157805906	91444715	40	2084										
OR6Y1	391112	broad.mit.edu	37	chr1	158517676	158517676	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtgacataccacatctccaGgaaggagaggtggctcaaga	12	9	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:158517676G>C	uc010pil.1	-	1	220	c.220C>G	c.(220-222)CTG>GTG	p.L74V		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CACATCTCCAGGAAGGAGAGG	0.463													0	0	0	0.001984	0	7	88										C	158517676	G	C	158517676	3	2	8	1	0	0	0	0	1	0	0	0	11213	991	35	4	759	4	OR6Y1	1	158517676	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	711770	158517676	90732945	41	2085										
SPTA1	6708	broad.mit.edu	37	chr1	158650449	158650449	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccagctccacttggaagtctTcaaatttcttatgcagaact	6	11	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:158650449T>C	uc001fst.1	-	5	801	c.602A>G	c.(601-603)GAA>GGA	p.E201G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	201	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTGGAAGTCTTCAAATTTCTT	0.473													0	0	0	0.009096	0	4	141										C	158650449	T	C	158650449	3	2	8	1	0	0	0	0	1	0	0	0	15115	1783	62	5	6849	5	SPTA1	1	158650449	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	132773	158650449	90600172	42	2086										
FCER1A	2205	broad.mit.edu	37	chr1	159273848	159273848	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaatggttccacaatggcagCctttcagaagagacaaattc	8	9	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:159273848C>T	uc001ftq.2	+	4	306	c.207C>T	c.(205-207)AGC>AGT	p.S69S		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	69	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	ACAATGGCAGCCTTTCAGAAG	0.368													0	0	0	0.01441	0	67	37										T	159273848	C	T	159273848	2	4	8	1	0	0	0	0	0	0	0	1	5774	738	26	2		2	FCER1A	1	159273848	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	623399	159273848	89976773	43	2087										
CCDC19	25790	broad.mit.edu	37	chr1	159854250	159854250	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agatcttcctcttggagctgTtccatatattccagcatctg	7	11	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:159854250T>A	uc001fui.2	-	7	891	c.873A>T	c.(871-873)GAA>GAT	p.E291D	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.E206D|CCDC19_uc001ful.2_Missense_Mutation_p.E206D|CCDC19_uc009wtc.1_Missense_Mutation_p.E277D	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	291	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			CTTGGAGCTGTTCCATATATT	0.522													0	0	0	0.003954	0	23	285										A	159854250	T	A	159854250	3	1	8	1	0	0	0	0	1	0	0	0	2795	1722	60	5	806	5	CCDC19	1	159854250	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	580402	159854250	89396371	44	2088										
IGSF9	57549	broad.mit.edu	37	chr1	159897153	159897153	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gttcacagcagagtggcctgTtcggggtgggggactggctg	19	8	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:159897153T>C	uc001fur.2	-	21	3720	c.3522A>G	c.(3520-3522)GAA>GAG	p.E1174E	IGSF9_uc001fuq.2_Silent_p.E1158E|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.E320E	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1174	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GAGTGGCCTGTTCGGGGTGGG	0.602													0	0	0	0.01441	0	90	61										C	159897153	T	C	159897153	2	2	8	1	0	0	0	0	0	0	0	1	7605	1722	60	5		5	IGSF9	1	159897153	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	42903	159897153	89353468	45	2089										
SDHC	6391	broad.mit.edu	37	chr1	161293414	161293414	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tatcttgcagacacgttggtCgtcattgcctccgagcccac	9	14	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:161293414C>T	uc001gag.2	+	2	61	c.31C>T	c.(31-33)CGT>TGT	p.R11C	SDHC_uc001gai.2_Missense_Mutation_p.R11C|SDHC_uc001gaj.2_Intron|SDHC_uc001gak.2_Missense_Mutation_p.R11C|SDHC_uc001gah.2_Missense_Mutation_p.R11C	NM_003001	NP_002992	Q99643	C560_HUMAN	succinate dehydrogenase complex, subunit C	11					respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II|plasma membrane succinate dehydrogenase complex	electron carrier activity|heme binding|succinate dehydrogenase activity				0	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Succinic acid(DB00139)	ACACGTTGGTCGTCATTGCCT	0.328			Mis|N|F			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome				0	0	0	0.009096	0	4	66										T	161293414	C	T	161293414	3	4	8	1	0	0	0	0	1	0	0	0	13966	884	31	1	37	1	SDHC	1	161293414	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1396261	161293414	87957207	46	2090										
PAPPA2	60676	broad.mit.edu	37	chr1	176740114	176740114	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tggagtcaggactgagcccaTggctgacatgtcttgaagat	13	8	2	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:176740114T>A	uc001gkz.2	+	17	5677	c.4513T>A	c.(4513-4515)TGG>AGG	p.W1505R	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1505	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACTGAGCCCATGGCTGACATG	0.458													0	0	0	0.000602	0	5	73										A	176740114	T	A	176740114	3	1	8	1	0	0	0	0	1	0	0	0	11433	1464	51	5	4628	5	PAPPA2	1	176740114	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	15446700	176740114	72510507	47	2091										
TOR3A	64222	broad.mit.edu	37	chr1	179051393	179051393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gctcggcctgggcctggccgGgcttccagcgcctgcaggag	17	15	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:179051393G>A	uc001gmd.2	+	1	282	c.130G>A	c.(130-132)GGC>AGC	p.G44S	TOR3A_uc010pnd.1_5'UTR	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	44					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						GGCCTGGCCGGGCTTCCAGCG	0.726													0	0	0	0.000602	0	4	7										A	179051393	G	A	179051393	3	1	8	1	0	0	0	0	1	0	0	0	16373	1232	43	2	132	2	TOR3A	1	179051393	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2311279	179051393	70199228	48	2092										
CEP350	9857	broad.mit.edu	37	chr1	180012207	180012207	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttagatggcagagttgactaGaactcatatctcagatgctg	10	7	2	5			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:180012207G>T	uc001gnt.2	+	20	4762	c.4379G>T	c.(4378-4380)AGA>ATA	p.R1460I	CEP350_uc009wxl.2_Missense_Mutation_p.R1459I	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1460						centrosome|nucleus|spindle				ovary(4)	4						GAGTTGACTAGAACTCATATC	0.373													1	0	9.70103e-10	0.008291	1.12298e-09	10	194										T	180012207	G	T	180012207	3	4	8	1	0	0	0	0	1	0	0	0	3254	942	33	3	4453	3	CEP350	1	180012207	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	960814	180012207	69238414	49	2093										
IER5	51278	broad.mit.edu	37	chr1	181058781	181058781	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gccccgccggaacttagagcAgccgccgagtggaggagagg	17	12	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:181058781A>C	uc001got.3	+	1	1144	c.743A>C	c.(742-744)CAG>CCG	p.Q248P		NM_016545	NP_057629	Q5VY09	IER5_HUMAN	immediate early response 5	248										pancreas(1)	1						AACTTAGAGCAGCCGCCGAGT	0.478													0	0	0	0.001168	0	6	34										C	181058781	A	C	181058781	3	2	8	1	0	0	0	0	1	0	0	0	7508	188	7	5	745	5	IER5	1	181058781	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	1046574	181058781	68191840	50	2094										
DHX9	1660	broad.mit.edu	37	chr1	182823164	182823164	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	taattatcattgattctacaGactctagaatcagaagaagt	6	6	4	5			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:182823164G>A	uc001gpr.2	+	6	641	c.478_splice	c.e6-1	p.T160_splice	DHX9_uc001gps.2_Splice_Site	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9						CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TGATTCTACAGACTCTAGAAT	0.328													0	0	0	0.001168	0	5	144										A	182823164	G	A	182823164	5	1	8	1	0	0	0	0	0	0	1	0	4516	956	33	1	495	1	DHX9	1	182823164	Splice_Site	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1764383	182823164	66427457	51	2095										
HMCN1	83872	broad.mit.edu	37	chr1	186023082	186023082	+	Frame_Shift_Del	DEL	G	G	-													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtgtggcgtcgaatgttgctGggactgcaaagaaagaatac							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:186023082delG	uc001grq.1	+	44	7055	c.6826delG	c.(6826-6828)GGGfs	p.G2276fs		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2276	Ig-like C2-type 20.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAATGTTGCTGGGACTGCAAA	0.398																		11	93	---	---								-	186023082	G	-	186023082	7	5	8	1	0	1	0	1	0	0	0	0	7220	1348	47	0	7000	0	HMCN1	1	186023082	Frame_Shift_Del	DEL	G	TCGA-BT-A20N-01A-11D-A14W-08	3199918	186023082	63227539	52	2096										
HMCN1	83872	broad.mit.edu	37	chr1	186062301	186062301	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcacattaaacatttatgGagctcttacatctgacacgg	7	10	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:186062301G>C	uc001grq.1	+	65	10152	c.9923G>C	c.(9922-9924)GGA>GCA	p.G3308A		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3308	Ig-like C2-type 31.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AACATTTATGGAGCTCTTACA	0.383													0	0	0	0.009096	0	4	125										C	186062301	G	C	186062301	3	2	8	1	0	0	0	0	1	0	0	0	7220	1174	41	1	10181	1	HMCN1	1	186062301	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	39219	186062301	63188320	53	2097										
RGS18	64407	broad.mit.edu	37	chr1	192127861	192127861	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tacatggttcaggaaaagaaGaaacaagcaaagaagccaaa	9	6	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:192127861G>A	uc001gsg.2	+	1	270	c.94G>A	c.(94-96)GAA>AAA	p.E32K		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	32					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						AGGAAAAGAAGAAACAAGCAA	0.289													0	0	0	0.009096	0	3	53										A	192127861	G	A	192127861	3	1	8	1	0	0	0	0	1	0	0	0	13300	943	33	1	96	1	RGS18	1	192127861	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6065560	192127861	57122760	54	2098										
ASPM	259266	broad.mit.edu	37	chr1	197073873	197073873	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttcttttatataacttttggGcttgaaagcaccgaaatctt	6	7	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:197073873G>A	uc001gtu.2	-	18	4765	c.4508C>T	c.(4507-4509)GCC>GTC	p.A1503V	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1503					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TAACTTTTGGGCTTGAAAGCA	0.323													0	0	0	0.008291	0	11	81										A	197073873	G	A	197073873	3	1	8	1	0	0	0	0	1	0	0	0	1056	1203	42	2	5969	2	ASPM	1	197073873	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	4946012	197073873	52176748	55	2099										
PTPRC	5788	broad.mit.edu	37	chr1	198719627	198719627	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttttgtctaaaaagagctacTggaaacctgaagtgatgatt	9	5	1	4	rs146768191		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:198719627T>A	uc001gur.1	+	29	3253	c.3073T>A	c.(3073-3075)TGG>AGG	p.W1025R	PTPRC_uc001gus.1_Missense_Mutation_p.W977R|PTPRC_uc001gut.1_Missense_Mutation_p.W864R	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1025	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						AAAGAGCTACTGGAAACCTGA	0.383													0	0	0	0.006214	0	6	74										A	198719627	T	A	198719627	3	1	8	1	0	0	0	0	1	0	0	0	12797	1580	55	5	3194	5	PTPRC	1	198719627	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	1645754	198719627	50530994	56	2100										
NR5A2	2494	broad.mit.edu	37	chr1	200017817	200017817	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaaatcatggcctatttgcaGcaagagcaggctaaccgaag	10	9	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:200017817G>A	uc001gvb.2	+	5	1187	c.981G>A	c.(979-981)CAG>CAA	p.Q327Q	NR5A2_uc001gvc.2_Silent_p.Q281Q|NR5A2_uc009wzh.2_Silent_p.Q287Q|NR5A2_uc010pph.1_Silent_p.Q255Q	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	327					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCTATTTGCAGCAAGAGCAGG	0.493													0	0	0	0.003163	0	15	83										A	200017817	G	A	200017817	2	1	8	1	0	0	0	0	0	0	0	1	10636	962	34	2		2	NR5A2	1	200017817	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1298190	200017817	49232804	57	2101										
FAM71A	149647	broad.mit.edu	37	chr1	212798782	212798782	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcagtacctgtggcattcCagctgaagacatgatgtgga	12	9	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:212798782C>A	uc001hjk.2	+	1	967	c.563C>A	c.(562-564)CCA>CAA	p.P188Q	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	188										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		TGTGGCATTCCAGCTGAAGAC	0.532													1	0	1.08611e-07	0.010729	1.22225e-07	12	74										A	212798782	C	A	212798782	3	1	8	1	0	0	0	0	1	0	0	0	5607	594	21	4	565	4	FAM71A	1	212798782	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	12780965	212798782	36451839	58	2102										
DUSP10	11221	broad.mit.edu	37	chr1	221879668	221879668	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gggggtgagctcagcgttctCgatgtcaggggtggtgggga	21	6	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:221879668C>A	uc001hmy.1	-	3	1134	c.952G>T	c.(952-954)GAG>TAG	p.E318*	DUSP10_uc001hmx.1_5'UTR|DUSP10_uc001hmz.1_5'UTR	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	318					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		TCAGCGTTCTCGATGTCAGGG	0.632													1	0	2.7689e-08	0.001984	3.15998e-08	6	167										A	221879668	C	A	221879668	4	1	8	1	0	0	0	0	0	1	0	0	4810	893	31	3	504	3	DUSP10	1	221879668	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	9080886	221879668	27370953	59	2103										
OBSCN	84033	broad.mit.edu	37	chr1	228471295	228471295	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgcaagacggagcaccccgcGgccacagtgacctggcgcaa	13	15	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr1:228471295G>A	uc009xez.1	+	33	8873	c.8829G>A	c.(8827-8829)GCG>GCA	p.A2943A	OBSCN_uc001hsn.2_Silent_p.A2943A|OBSCN_uc001hsp.1_Silent_p.A642A|OBSCN_uc001hsq.1_Silent_p.A199A	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2943	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGCACCCCGCGGCCACAGTGA	0.632													0	0	0	0.004672	0	3	37										A	228471295	G	A	228471295	2	1	8	1	0	0	0	0	0	0	0	1	10812	1103	39	2		2	OBSCN	1	228471295	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6591627	228471295	20779326	60	2104										
RHOB	388	broad.mit.edu	37	chr2	20647450	20647450	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctgcggccgctctcctaccCggacaccgacgtcattctca	8	19	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:20647450C>T	uc002rdv.2	+	1	616	c.224C>T	c.(223-225)CCG>CTG	p.P75L		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CTCTCCTACCCGGACACCGAC	0.647													0	0	0	0.012319	0	22	65										T	20647450	C	T	20647450	3	4	8	1	0	0	0	0	1	0	0	0	13332	652	23	2	226	2	RHOB	2	20647450	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		20647450	222551923	61	2105										
ASXL2	55252	broad.mit.edu	37	chr2	25965729	25965729	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagtctgtatatcccattttCaaggcttcagtggggctgct	10	10	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:25965729C>G	uc002rgs.2	-	12	3698	c.3477G>C	c.(3475-3477)TTG>TTC	p.L1159F	ASXL2_uc002rgt.1_Missense_Mutation_p.L642F	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCCCATTTTCAAGGCTTCAG	0.458													0	0	0	0.004656	0	27	60										G	25965729	C	G	25965729	3	3	8	1	0	0	0	0	1	0	0	0	1067	825	29	1	834	1	ASXL2	2	25965729	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	5318279	25965729	217233644	62	2106										
BIRC6	57448	broad.mit.edu	37	chr2	32716552	32716552	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcatttgttggtttcagatcCaaacctaattcatgtattag	6	7	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:32716552C>G	uc010ezu.2	+	44	8401	c.8267C>G	c.(8266-8268)CCA>CGA	p.P2756R		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2756					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GTTTCAGATCCAAACCTAATT	0.388													0	0	0	0.013726	0	34	57										G	32716552	C	G	32716552	3	3	8	1	0	0	0	0	1	0	0	0	1438	594	21	4	8441	4	BIRC6	2	32716552	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6750823	32716552	210482821	63	2107										
FSHR	2492	broad.mit.edu	37	chr2	49190073	49190073	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tctctgcgaaagtttttggtAaagatggcatagaggaaggg	14	4	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:49190073A>G	uc002rww.2	-	10	1961	c.1887T>C	c.(1885-1887)TTT>TTC	p.F629F	FSHR_uc002rwx.2_Silent_p.F567F|FSHR_uc010fbn.2_Silent_p.F603F	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	629	Helical; Name=7; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	AGTTTTTGGTAAAGATGGCAT	0.468									Gonadal_Dysgenesis_46_XX				0	0	0	0.000602	0	5	37										G	49190073	A	G	49190073	2	3	8	1	0	0	0	0	0	0	0	1	6073	359	13	5		5	FSHR	2	49190073	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	16473521	49190073	194009300	64	2108										
PSME4	23198	broad.mit.edu	37	chr2	54093286	54093286	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acaagcagttggtcatcagtGaattgctgtttatgttcctg	10	7	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:54093286G>A	uc002rxp.2	-	46	5528	c.5472C>T	c.(5470-5472)TTC>TTT	p.F1824F	PSME4_uc010yop.1_Silent_p.F1714F|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.F1199F|PSME4_uc010fbv.1_Silent_p.F968F|PSME4_uc010fbt.1_Silent_p.F259F	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1824					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GGTCATCAGTGAATTGCTGTT	0.398													0	0	0	0.003954	0	23	78										A	54093286	G	A	54093286	2	1	8	1	0	0	0	0	0	0	0	1	12709	1281	45	1		1	PSME4	2	54093286	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	4903213	54093286	189106087	65	2109										
MEIS1	4211	broad.mit.edu	37	chr2	66775088	66775088	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctttcagcacccttacccttCtgaagaacagaaaaagcagt	6	12	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:66775088C>T	uc002sdu.2	+	9	1359	c.902C>T	c.(901-903)TCT>TTT	p.S301F	MEIS1_uc002sdt.2_Missense_Mutation_p.S301F|MEIS1_uc002sdv.2_Missense_Mutation_p.S299F|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Missense_Mutation_p.S236F|MEIS1_uc002sdw.1_Missense_Mutation_p.S157F	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	301	Homeobox; TALE-type.						sequence-specific DNA binding transcription factor activity				0						CCTTACCCTTCTGAAGAACAG	0.383													0	0	0	0.014323	0	20	26										T	66775088	C	T	66775088	3	4	8	1	0	0	0	0	1	0	0	0	9467	913	32	1	936	1	MEIS1	2	66775088	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	12681802	66775088	176424285	66	2110										
ARHGAP25	9938	broad.mit.edu	37	chr2	69015022	69015022	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	actcctatgtcctcatggccAgctctcaggcggagatggag	12	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:69015022A>T	uc002seu.2	+	4	764	c.400A>T	c.(400-402)AGC>TGC	p.S134C	ARHGAP25_uc010yqk.1_Missense_Mutation_p.S108C|ARHGAP25_uc010fdg.2_Missense_Mutation_p.S134C|ARHGAP25_uc010yql.1_Intron|ARHGAP25_uc002sev.2_Missense_Mutation_p.S127C|ARHGAP25_uc002sew.2_Missense_Mutation_p.S127C|ARHGAP25_uc002sex.2_Missense_Mutation_p.S127C|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	134	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CCTCATGGCCAGCTCTCAGGC	0.542													0	0	0	0.004672	0	3	72										T	69015022	A	T	69015022	3	4	8	1	0	0	0	0	1	0	0	0	874	188	7	5	454	5	ARHGAP25	2	69015022	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	2239934	69015022	174184351	67	2111										
KIAA1310	55683	broad.mit.edu	37	chr2	97275285	97275287	+	In_Frame_Del	DEL	TTT	TTT	-													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcaacccttctgatttcttcTttgctttgcttattctaaga							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:97275285_97275287delTTT	uc002swn.3	-	12	1478_1480	c.1332_1334delAAA	c.(1330-1335)GCAAAG>GCG	p.K447del	KIAA1310_uc002swh.3_In_Frame_Del_p.K335del|KIAA1310_uc002swi.3_In_Frame_Del_p.K348del|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_In_Frame_Del_p.K360del|KIAA1310_uc010fhz.2_In_Frame_Del_p.K241del|KIAA1310_uc002swl.3_In_Frame_Del_p.K348del|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_In_Frame_Del_p.K241del|KIAA1310_uc002swp.1_In_Frame_Del_p.K348del|KIAA1310_uc002swq.1_In_Frame_Del_p.K219del|KIAA1310_uc010fhy.1_In_Frame_Del_p.K348del	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	447											0						TGATTTCTTCTTTGCTTTGCTTA	0.384																		9	322	---	---								-	97275287	TTT	-	97275285	7	5	8	1	0	1	0	1	0	0	0	0	8222	1609	56	0	1342	0	KIAA1310	2	97275285	In_Frame_Del	DEL	TTT	TCGA-BT-A20N-01A-11D-A14W-08	28260263	97275285	145924088	68	2112										
TGFBRAP1	9392	broad.mit.edu	37	chr2	105883968	105883968	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaagggattttggcatatctGacaaagctttttgtctgaga	10	5	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:105883968G>C	uc002tcq.2	-	12	2539	c.2455C>G	c.(2455-2457)CAG>GAG	p.Q819E	TGFBRAP1_uc010fjc.2_Missense_Mutation_p.Q588E|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.Q819E|uc002tcp.2_5'Flank	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	819					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						TGGCATATCTGACAAAGCTTT	0.433													0	0	0	0.014323	0	23	116										C	105883968	G	C	105883968	3	2	8	1	0	0	0	0	1	0	0	0	15821	1299	45	1	131	1	TGFBRAP1	2	105883968	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	8608683	105883968	137315405	69	2113										
RGPD3	653489	broad.mit.edu	37	chr2	107040796	107040796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acttttgtttgatcatttgtCaaaaatgttttgaaatcttt	5	4	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:107040796C>G	uc010ywi.1	-	20	3684	c.3627G>C	c.(3625-3627)TTG>TTC	p.L1209F		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1209					intracellular transport		binding			ovary(1)	1						GATCATTTGTCAAAAATGTTT	0.408													0	0	0	0.009718	0	37	192										G	107040796	C	G	107040796	3	3	8	1	0	0	0	0	1	0	0	0	13287	825	29	1	1665	1	RGPD3	2	107040796	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1156828	107040796	136158577	70	2114										
MALL	7851	broad.mit.edu	37	chr2	110849283	110849283	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcgagacatacatcacccatCcttgcagcaaggggtatact	9	12	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:110849283C>G	uc002tfk.2	-	2	944	c.170G>C	c.(169-171)GGA>GCA	p.G57A	MALL_uc010fju.2_Intron	NM_005434	NP_005425	Q13021	MALL_HUMAN	mal, T-cell differentiation protein-like	57	MARVEL.				cholesterol homeostasis	clathrin-coated vesicle|Golgi membrane|integral to membrane|membrane raft|plasma membrane	protein binding			ovary(1)|skin(1)	2				Epithelial(1;0.0546)|STAD - Stomach adenocarcinoma(1;0.18)		CATCACCCATCCTTGCAGCAA	0.433													0	0	0	0.000602	0	4	71										G	110849283	C	G	110849283	3	3	8	1	0	0	0	0	1	0	0	0	9201	855	30	1	303	1	MALL	2	110849283	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3808487	110849283	132350090	71	2115										
SAP130	79595	broad.mit.edu	37	chr2	128775266	128775266	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tccattaccttcataagtccCtccgaaaatgaaagtggcac	6	12	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:128775266C>G	uc002tpp.2	-	3	546	c.414G>C	c.(412-414)GAG>GAC	p.E138D	SAP130_uc002tpo.2_5'Flank|SAP130_uc010fmd.2_Missense_Mutation_p.E138D|SAP130_uc002tpq.1_Missense_Mutation_p.E112D	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	138	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TCATAAGTCCCTCCGAAAATG	0.478													0	0	0	0.014323	0	20	27										G	128775266	C	G	128775266	3	3	8	1	0	0	0	0	1	0	0	0	13831	680	24	4	2913	4	SAP130	2	128775266	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	17925983	128775266	114424107	72	2116										
LCT	3938	broad.mit.edu	37	chr2	136567117	136567117	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccctggtgtgtgggtaaagtTatcccagatgctggggcctt	14	9	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:136567117T>C	uc002tuu.1	-	8	2811	c.2800A>G	c.(2800-2802)AAC>GAC	p.N934D		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	934	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGGGTAAAGTTATCCCAGATG	0.552													0	0	0	0.009096	0	4	61										C	136567117	T	C	136567117	3	2	8	1	0	0	0	0	1	0	0	0	8693	1754	61	5	3023	5	LCT	2	136567117	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	7791851	136567117	106632256	73	2117										
ORC4L	5000	broad.mit.edu	37	chr2	148705641	148705641	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgaacattttcattccacttCtcagcaaaaaccttgtctgg	5	11	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:148705641C>T	uc002twi.2	-	9	876	c.741G>A	c.(739-741)GAG>GAA	p.E247E	ORC4L_uc002twj.2_Silent_p.E247E|ORC4L_uc010zbo.1_Silent_p.E173E|ORC4L_uc010zbp.1_Silent_p.E30E|ORC4L_uc010fnr.2_Silent_p.E247E|ORC4L_uc010zbq.1_Silent_p.E163E|ORC4L_uc002twk.2_Silent_p.E247E|ORC4L_uc010zbr.1_Silent_p.E247E	NM_181741	NP_859525	O43929	ORC4_HUMAN	origin recognition complex subunit 4	247					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.0963)|COAD - Colon adenocarcinoma(177;0.203)		CATTCCACTTCTCAGCAAAAA	0.294													0	0	0	0.001168	0	6	94										T	148705641	C	T	148705641	2	4	8	1	0	0	0	0	0	0	0	1	11264	912	32	1		1	ORC4L	2	148705641	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	12138524	148705641	94493732	74	2118										
SCN2A	6326	broad.mit.edu	37	chr2	166229818	166229818	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctcagaacactaagagctctGaggccactgagagctttgtc	10	11	2	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:166229818G>A	uc002udc.2	+	21	4223	c.3933G>A	c.(3931-3933)CTG>CTA	p.L1311L	SCN2A_uc002udd.2_Silent_p.L1311L|SCN2A_uc002ude.2_Silent_p.L1311L	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1311	III.|Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TAAGAGCTCTGAGGCCACTGA	0.433													0	0	0	0.009096	0	4	85										A	166229818	G	A	166229818	2	1	8	1	0	0	0	0	0	0	0	1	13916	1277	45	1		1	SCN2A	2	166229818	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	17524177	166229818	76969555	75	2119										
XIRP2	129446	broad.mit.edu	37	chr2	168101392	168101392	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tccaaggtggggatgttcgtAcagcatgttttctttttgag	12	6	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:168101392A>G	uc002udx.2	+	8	3508	c.3490A>G	c.(3490-3492)ACA>GCA	p.T1164A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.T989A|XIRP2_uc010fpq.2_Missense_Mutation_p.T942A|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	989	Xin 18.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GGATGTTCGTACAGCATGTTT	0.398													0	0	0	0.009535	0	29	40										G	168101392	A	G	168101392	3	3	8	1	0	0	0	0	1	0	0	0	17427	391	14	5	3520	5	XIRP2	2	168101392	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	1871574	168101392	75097981	76	2120										
XIRP2	129446	broad.mit.edu	37	chr2	168108453	168108453	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	caagaggaatctgcatttatAagtggtaaatgagcttgcaa	10	5	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:168108453A>C	uc002udx.2	+	8	10569	c.10551A>C	c.(10549-10551)ATA>ATC	p.I3517I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.I3342I|XIRP2_uc010fpq.2_Silent_p.I3295I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3342					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTGCATTTATAAGTGGTAAAT	0.408													0	0	0	0.001168	0	4	68										C	168108453	A	C	168108453	2	2	8	1	0	0	0	0	0	0	0	1	17427	352	13	5		5	XIRP2	2	168108453	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	7061	168108453	75090920	77	2121										
TTN	7273	broad.mit.edu	37	chr2	179431334	179431334	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gccatcatagatgggtttacCccaggcaagtgtgattgaat	11	8	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:179431334C>G	uc010zfg.1	-	275	72045	c.71821G>C	c.(71821-71823)GGT>CGT	p.G23941R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G17636R|TTN_uc010zfi.1_Missense_Mutation_p.G17569R|TTN_uc010zfj.1_Missense_Mutation_p.G17444R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGGTTTACCCCAGGCAAGT	0.423													0	0	0	0.00333	0	24	206										G	179431334	C	G	179431334	3	3	8	1	0	0	0	0	1	0	0	0	16732	623	22	4	28602	4	TTN	2	179431334	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	11322881	179431334	63768039	78	2122										
TTN	7273	broad.mit.edu	37	chr2	179547564	179547564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	attcctcatattcttcttccCgttgtactgaaacagcttct	4	12	4	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:179547564C>T	uc010zfg.1	-	132	29446	c.29222G>A	c.(29221-29223)CGG>CAG	p.R9741Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R6402Q|TTN_uc010fre.1_Missense_Mutation_p.R588Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10668							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTCTTCCCGTTGTACTGA	0.353													0	0	0	0.001168	0	6	57										T	179547564	C	T	179547564	3	4	8	1	0	0	0	0	1	0	0	0	16732	652	23	2	71487	2	TTN	2	179547564	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	116230	179547564	63651809	79	2123										
TTN	7273	broad.mit.edu	37	chr2	179596956	179596956	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctctccttaatttctctatcAtttgcaaaccatgttatttt	2	10	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:179596956A>C	uc010zfg.1	-	54	13232	c.13008T>G	c.(13006-13008)AAT>AAG	p.N4336K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N997K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5263							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTCTATCATTTGCAAACC	0.423													0	0	0	0.01441	0	62	85										C	179596956	A	C	179596956	3	2	8	1	0	0	0	0	1	0	0	0	16732	214	8	5	88013	5	TTN	2	179596956	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	49392	179596956	63602417	80	2124										
COL5A2	1290	broad.mit.edu	37	chr2	190044277	190044277	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttattgagacaaattgcccTaataaaacaataagaatgag	6	5	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:190044277T>A	uc002uqk.2	-	1	329	c.54A>T	c.(52-54)TTA>TTT	p.L18F		NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	18					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CAAATTGCCCTAATAAAACAA	0.413													0	0	0	0.007413	0	16	21										A	190044277	T	A	190044277	3	1	8	1	0	0	0	0	1	0	0	0	3697	1519	53	5	4661	5	COL5A2	2	190044277	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	10447321	190044277	53155096	81	2125										
STAT1	6772	broad.mit.edu	37	chr2	191847151	191847151	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gttcagctggtccacattgaGacctcttttggtgacagaag	11	9	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:191847151G>C	uc002usj.2	-	18	1928	c.1540C>G	c.(1540-1542)CTC>GTC	p.L514V	STAT1_uc010fse.1_Missense_Mutation_p.L514V|STAT1_uc002usk.2_Missense_Mutation_p.L514V|STAT1_uc002usl.2_Missense_Mutation_p.L516V|STAT1_uc010fsf.1_Missense_Mutation_p.L326V	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	514					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TCCACATTGAGACCTCTTTTG	0.398													0	0	0	0.004289	0	34	100										C	191847151	G	C	191847151	3	2	8	1	0	0	0	0	1	0	0	0	15263	942	33	1	748	1	STAT1	2	191847151	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1802874	191847151	51352222	82	2126										
HECW2	57520	broad.mit.edu	37	chr2	197092943	197092943	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agagttctctggataccaggAagaaaaactctctagaaggc	10	8	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:197092943A>G	uc002utm.1	-	22	3983	c.3800T>C	c.(3799-3801)TTC>TCC	p.F1267S	HECW2_uc002utl.1_Missense_Mutation_p.F911S	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1267	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGATACCAGGAAGAAAAACTC	0.348													0	0	0	0.00245	0	12	46										G	197092943	A	G	197092943	3	3	8	1	0	0	0	0	1	0	0	0	7043	246	9	5	950	5	HECW2	2	197092943	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	5245792	197092943	46106430	83	2127										
GTF3C3	9330	broad.mit.edu	37	chr2	197641263	197641263	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gctgaagggtagaaagtgaaAtccttgcatccaaatggagt	12	6	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:197641263A>G	uc002uts.2	-	11	1571	c.1481T>C	c.(1480-1482)ATT>ACT	p.I494T	GTF3C3_uc010zgu.1_Missense_Mutation_p.I465T	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	494	TPR 9.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						AGAAAGTGAAATCCTTGCATC	0.473													0	0	0	0.009096	0	4	114										G	197641263	A	G	197641263	3	3	8	1	0	0	0	0	1	0	0	0	6874	101	4	5	1211	5	GTF3C3	2	197641263	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	548320	197641263	45558110	84	2128										
SPEG	10290	broad.mit.edu	37	chr2	220337015	220337015	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacggggaggatggtcacacTcacatggaacccccccagga	13	13	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:220337015T>A	uc010fwg.2	+	15	3902	c.3902T>A	c.(3901-3903)CTC>CAC	p.L1301H		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1301	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ATGGTCACACTCACATGGAAC	0.647													0	0	0	0.004482	0	7	38										A	220337015	T	A	220337015	3	1	8	1	0	0	0	0	1	0	0	0	15035	1551	54	5	3972	5	SPEG	2	220337015	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	22695752	220337015	22862358	85	2129										
IRS1	3667	broad.mit.edu	37	chr2	227660807	227660808	+	In_Frame_Ins	INS	-	-	GCT													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctctggagggtgcagcaaggINSgctgctgctgctgctgctgc							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:227660807_227660808insGCT	uc002voh.3	-	1	2699_2700	c.2647_2648insAGC	c.(2647-2649)CCC>CAGCCC	p.882_883insQ		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	882_883					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GTGCAGCAAGGgctgctgctgc	0.554																		13	39	---	---								GCT	227660808	-	GCT	227660807	7	5	8	1	0	1	1	0	0	0	0	0	7840	1232	43	0	1084	0	IRS1	2	227660807	In_Frame_Ins	INS	-	TCGA-BT-A20N-01A-11D-A14W-08	7323792	227660807	15538566	86	2130										
CAPN10	11132	broad.mit.edu	37	chr2	241531491	241531491	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacaggccaggccgctgggaGcacaggacttgtcggcagct	16	12	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:241531491G>A	uc002vzk.1	+	4	796	c.612G>A	c.(610-612)GAG>GAA	p.E204E	CAPN10_uc010zoh.1_Silent_p.E204E|CAPN10_uc002vzl.1_Silent_p.E204E|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.E76E|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	204	Calpain catalytic.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		GCCGCTGGGAGCACAGGACTT	0.657													0	0	0	0.00308	0	7	8										A	241531491	G	A	241531491	2	1	8	1	0	0	0	0	0	0	0	1	2623	962	34	2		2	CAPN10	2	241531491	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	13870684	241531491	1667882	87	2131										
MTERFD2	130916	broad.mit.edu	37	chr2	242038846	242038846	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcttttgcaggtaactggagCgcttcctcatttgcataata	9	9	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr2:242038846C>T	uc002wan.1	-	1	1065	c.572G>A	c.(571-573)CGC>CAC	p.R191H	MTERFD2_uc010zoj.1_Intron|MTERFD2_uc010zok.1_Missense_Mutation_p.R162H	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	162										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		GTAACTGGAGCGCTTCCTCAT	0.338													0	0	0	0.008291	0	10	118										T	242038846	C	T	242038846	3	4	8	1	0	0	0	0	1	0	0	0	9920	768	27	2	672	2	MTERFD2	2	242038846	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	507355	242038846	1160527	88	2132										
ATP2B2	491	broad.mit.edu	37	chr3	10417161	10417161	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacggccagagggagcccctCgggcacggcgaccaccagca	15	16	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:10417161C>G	uc003bvt.2	-	11	1808	c.1369G>C	c.(1369-1371)GAG>CAG	p.E457Q	ATP2B2_uc003bvv.2_Missense_Mutation_p.E412Q|ATP2B2_uc003bvw.2_Missense_Mutation_p.E412Q|ATP2B2_uc010hdo.2_Missense_Mutation_p.E162Q	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	457	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GGGAGCCCCTCGGGCACGGCG	0.622													0	0	0	0.003954	0	22	90										G	10417161	C	G	10417161	3	3	8	1	0	0	0	0	1	0	0	0	1140	893	31	1	2414	1	ATP2B2	3	10417161	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		10417161	187605269	89	2133										
ARPP21	10777	broad.mit.edu	37	chr3	35770879	35770879	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gagcacacccctagtctcagGtgtggcagctggctctccag	12	14	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:35770879G>T	uc003cgb.2	+	15	1574	c.1310G>T	c.(1309-1311)GGT>GTT	p.G437V	ARPP21_uc003cga.2_Missense_Mutation_p.G383V|ARPP21_uc011axy.1_Missense_Mutation_p.G403V|ARPP21_uc003cgf.2_Missense_Mutation_p.G238V|ARPP21_uc003cgg.2_5'UTR	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	437						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CTAGTCTCAGGTGTGGCAGCT	0.587													1	0	5.18039e-06	0.00308	5.67176e-06	7	49										T	35770879	G	T	35770879	3	4	8	1	0	0	0	0	1	0	0	0	978	1261	44	4	1373	4	ARPP21	3	35770879	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	25353718	35770879	162251551	90	2134										
VILL	50853	broad.mit.edu	37	chr3	38047993	38047993	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggcaatggcagggcaggtgcCgtggccctgcaggccctcaa	16	13	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:38047993C>A	uc003chj.2	+	19	2545	c.2259C>A	c.(2257-2259)GCC>GCA	p.A753A	VILL_uc003chl.2_Silent_p.A753A	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	753					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GGGCAGGTGCCGTGGCCCTGC	0.622													1	0	5.19286e-32	0.01441	6.47505e-32	63	69										A	38047993	C	A	38047993	2	1	8	1	0	0	0	0	0	0	0	1	17162	639	23	4		4	VILL	3	38047993	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2277114	38047993	159974437	91	2135										
SCN10A	6336	broad.mit.edu	37	chr3	38739807	38739807	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acatgtcgtcgatgccagccTcccacctcacatggggaaag	10	14	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:38739807T>G	uc003ciq.2	-	27	4904	c.4904A>C	c.(4903-4905)GAG>GCG	p.E1635A		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1635	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GATGCCAGCCTCCCACCTCAC	0.552													0	0	0	0.000602	0	5	171										G	38739807	T	G	38739807	3	3	8	1	0	0	0	0	1	0	0	0	13912	1551	54	5	970	5	SCN10A	3	38739807	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	691814	38739807	159282623	92	2136										
RTP3	83597	broad.mit.edu	37	chr3	46542298	46542298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaatgtctattcctacgcatGccaaaaccacatctgtagga	7	11	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:46542298G>A	uc003cps.1	+	2	676	c.608G>A	c.(607-609)TGC>TAC	p.C203Y		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	203	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TCCTACGCATGCCAAAACCAC	0.428													0	0	0	0.009096	0	4	72										A	46542298	G	A	46542298	3	1	8	1	0	0	0	0	1	0	0	0	13735	1319	46	2	614	2	RTP3	3	46542298	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	7802491	46542298	151480132	93	2137										
SMARCC1	6599	broad.mit.edu	37	chr3	47755937	47755937	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttctggaattggtggatcttCaatttcagcatcaacatcat	7	8	6	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:47755937C>T	uc003crq.2	-	8	878	c.760G>A	c.(760-762)GAA>AAA	p.E254K	SMARCC1_uc011bbd.1_Missense_Mutation_p.E145K	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	254					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		GGTGGATCTTCAATTTCAGCA	0.244													0	0	0	0.00632	0	22	49										T	47755937	C	T	47755937	3	4	8	1	0	0	0	0	1	0	0	0	14775	835	29	1	2641	1	SMARCC1	3	47755937	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1213639	47755937	150266493	94	2138										
OR5K2	402135	broad.mit.edu	37	chr3	98217282	98217282	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atcagtttcattattctatgGatctatttttttcctataca	3	7	4	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:98217282G>T	uc011bgx.1	+	1	758	c.758G>T	c.(757-759)GGA>GTA	p.G253V		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TTATTCTATGGATCTATTTTT	0.328													1	0	0.00829132	0.008291	0.00861103	10	50										T	98217282	G	T	98217282	3	4	8	1	0	0	0	0	1	0	0	0	11167	1174	41	3	760	3	OR5K2	3	98217282	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	50461345	98217282	99805148	95	2139										
RPL24	6152	broad.mit.edu	37	chr3	101400024	101400024	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gctgaaactttcacaggcttCacaatcttttgcttaggtgc	8	10	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:101400024C>A	uc003dvh.1	-	6	472	c.429G>T	c.(427-429)GTG>GTT	p.V143V	RPL24_uc003dvi.1_Nonstop_Mutation_p.*122L	NM_000986	NP_000977	P83731	RL24_HUMAN	ribosomal protein L24	143					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TCACAGGCTTCACAATCTTTT	0.383													1	0	8.20599e-20	0.011902	1.00767e-19	38	106										A	101400024	C	A	101400024	2	1	8	1	0	0	0	0	0	0	0	1	13572	813	29	3		3	RPL24	3	101400024	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3182742	101400024	96622406	96	2140										
NEK11	79858	broad.mit.edu	37	chr3	130871348	130871348	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cacaccttctctccctgagaGatatccaaaagaactaaatg	5	12	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:130871348G>A	uc003eny.2	+	8	1090	c.764G>A	c.(763-765)AGA>AAA	p.R255K	NEK11_uc003enx.2_Missense_Mutation_p.R255K|NEK11_uc003eoa.2_Missense_Mutation_p.R255K|NEK11_uc003enz.2_Missense_Mutation_p.R73K|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_Missense_Mutation_p.R107K|NEK11_uc011bll.1_Intron|NEK11_uc011blm.1_Missense_Mutation_p.R255K|NEK11_uc010hto.1_Missense_Mutation_p.R107K	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	255	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						CTCCCTGAGAGATATCCAAAA	0.333													0	0	0	0.007413	0	19	84										A	130871348	G	A	130871348	3	1	8	1	0	0	0	0	1	0	0	0	10323	942	33	1	786	1	NEK11	3	130871348	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	29471324	130871348	67151082	97	2141										
MED12L	116931	broad.mit.edu	37	chr3	151102914	151102914	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atgtcatcacttgtgaacctAtgggttccttgattgacaca	8	9	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:151102914A>G	uc003eyp.2	+	34	4956	c.4918A>G	c.(4918-4920)ATG>GTG	p.M1640V	MED12L_uc011bnz.1_Missense_Mutation_p.M1500V|P2RY12_uc011boa.1_5'Flank|P2RY12_uc003eyx.1_5'Flank|MED12L_uc003eyy.1_Missense_Mutation_p.M803V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1640					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGTGAACCTATGGGTTCCTT	0.348													0	0	0	0.01441	0	109	77										G	151102914	A	G	151102914	3	3	8	1	0	0	0	0	1	0	0	0	9429	449	16	5	5052	5	MED12L	3	151102914	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	20231566	151102914	46919516	98	2142										
GPR149	344758	broad.mit.edu	37	chr3	154055940	154055940	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttcttagaggctggagttaTtttttgcccttctgcgctta	9	8	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:154055940T>C	uc003faa.2	-	4	1844	c.1744A>G	c.(1744-1746)ATA>GTA	p.I582V		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	582	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCTGGAGTTATTTTTTGCCCT	0.453													0	0	0	0.001984	0	6	272										C	154055940	T	C	154055940	3	2	8	1	0	0	0	0	1	0	0	0	6654	1493	52	5	455	5	GPR149	3	154055940	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	2953026	154055940	43966490	99	2143										
PLCH1	23007	broad.mit.edu	37	chr3	155212182	155212182	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttgaagttactggaatcaatGcggtaggcagaggggtaaat	14	4	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:155212182G>T	uc011bok.1	-	15	2260	c.1983C>A	c.(1981-1983)CGC>CGA	p.R661R	PLCH1_uc011boj.1_Silent_p.R661R|PLCH1_uc011bol.1_Silent_p.R643R	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	661	PI-PLC Y-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGGAATCAATGCGGTAGGCAG	0.453													1	0	0.000602214	0.000602	0.000628668	5	80										T	155212182	G	T	155212182	2	4	8	1	0	0	0	0	0	0	0	1	12037	1306	46	4		4	PLCH1	3	155212182	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1156242	155212182	42810248	100	2144										
VEPH1	79674	broad.mit.edu	37	chr3	156983384	156983384	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgtgttttccaccttttgatGaacttccatctgacttgctt	6	11	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:156983384G>A	uc003fbj.1	-	13	2513	c.2196C>T	c.(2194-2196)TTC>TTT	p.F732F	VEPH1_uc003fbk.1_Silent_p.F732F|VEPH1_uc010hvu.1_Silent_p.F687F	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	732	PH.					plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			ACCTTTTGATGAACTTCCATC	0.383													0	0	0	0.01441	0	55	60										A	156983384	G	A	156983384	2	1	8	1	0	0	0	0	0	0	0	1	17151	1281	45	1		1	VEPH1	3	156983384	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1771202	156983384	41039046	101	2145										
MECOM	2122	broad.mit.edu	37	chr3	168845829	168845829	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aagagctggtcacagtcttcGcagcgatattgccgttcttc	10	11	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:168845829G>T	uc003ffi.3	-	4	338	c.69C>A	c.(67-69)TGC>TGA	p.C23*	MECOM_uc010hwk.1_Nonsense_Mutation_p.C46*|MECOM_uc003ffj.3_Nonsense_Mutation_p.C87*|MECOM_uc011bpi.1_Nonsense_Mutation_p.C23*|MECOM_uc003ffn.3_Nonsense_Mutation_p.C23*|MECOM_uc003ffk.2_Nonsense_Mutation_p.C23*|MECOM_uc003ffl.2_Nonsense_Mutation_p.C183*|MECOM_uc011bpj.1_Nonsense_Mutation_p.C211*|MECOM_uc011bpk.1_Nonsense_Mutation_p.C13*|MECOM_uc010hwn.2_Nonsense_Mutation_p.C211*|MECOM_uc003ffm.1_Nonsense_Mutation_p.C87*	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	23	C2H2-type 1.|Interaction with MAPK9, SMAD3 and probably SUV39H1.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CACAGTCTTCGCAGCGATATT	0.433													1	0	0.00010058	0.013537	0.000107214	12	120										T	168845829	G	T	168845829	4	4	8	1	0	0	0	0	0	1	0	0	9422	1079	38	4	3141	4	MECOM	3	168845829	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	11862445	168845829	29176601	102	2146										
ARPM1	84517	broad.mit.edu	37	chr3	169485742	169485742	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttctgtctgaagcactgagCaacatgataccatggttctt	8	9	3	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:169485742C>G	uc003ffs.1	-	2	972	c.597G>C	c.(595-597)TTG>TTC	p.L199F	TERC_uc003ffr.1_5'Flank	NM_032487	NP_115876	Q9BYD9	ARPM1_HUMAN	actin related protein M1	199						cytoplasm|cytoskeleton					0	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;5.01e-59)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AAGCACTGAGCAACATGATAC	0.468													0	0	0	0.006214	0	7	118										G	169485742	C	G	169485742	3	3	8	1	0	0	0	0	1	0	0	0	976	709	25	4	525	4	ARPM1	3	169485742	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	639913	169485742	28536688	103	2147										
MFN1	55669	broad.mit.edu	37	chr3	179082125	179082125	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagagctggatagctggattGataagttttgcctagatgct	12	6	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:179082125G>C	uc003fjs.2	+	6	703	c.577G>C	c.(577-579)GAT>CAT	p.D193H	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.D221H|MFN1_uc010hxc.2_Missense_Mutation_p.D46H	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	193	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TAGCTGGATTGATAAGTTTTG	0.338													0	0	0	0.001168	0	5	57										C	179082125	G	C	179082125	3	2	8	1	0	0	0	0	1	0	0	0	9523	1290	45	1	595	1	MFN1	3	179082125	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	9596383	179082125	18940305	104	2148										
KNG1	3827	broad.mit.edu	37	chr3	186459867	186459867	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aggtgtaacagttaccttttCtgactttcaggactctgatc	8	9	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:186459867C>T	uc011bsa.1	+	10	1894	c.1682C>T	c.(1681-1683)TCT>TTT	p.S561F	KNG1_uc003fqr.2_Intron	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	561					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GTTACCTTTTCTGACTTTCAG	0.473													0	0	0	0.00308	0	8	103										T	186459867	C	T	186459867	3	4	8	1	0	0	0	0	1	0	0	0	8427	913	32	1	1720	1	KNG1	3	186459867	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	7377742	186459867	11562563	105	2149										
MASP1	5648	broad.mit.edu	37	chr3	187003830	187003830	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gggagaagcacagagcataaTagagaagcagccacctgaaa	12	8	0	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr3:187003830T>C	uc003frh.1	-	2	352	c.20A>G	c.(19-21)TAT>TGT	p.Y7C	MASP1_uc003fri.2_Missense_Mutation_p.Y7C|MASP1_uc003frj.2_Intron|MASP1_uc003frk.1_Missense_Mutation_p.Y7C|MASP1_uc011bse.1_5'UTR	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	7					complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CAGAGCATAATAGAGAAGCAG	0.468													0	0	0	0.001984	0	7	48										C	187003830	T	C	187003830	3	2	8	1	0	0	0	0	1	0	0	0	9322	1406	49	5	3084	5	MASP1	3	187003830	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	543963	187003830	11018600	106	2150										
MFSD7	84179	broad.mit.edu	37	chr4	677066	677066	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggaacactcgaccgccaactCcatggccacggggcccaccg	11	18	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:677066C>G	uc003gay.2	-	8	1144	c.1087G>C	c.(1087-1089)GAG>CAG	p.E363Q	MFSD7_uc003gaw.2_Missense_Mutation_p.E105Q|MFSD7_uc003gax.2_Missense_Mutation_p.E362Q|MFSD7_uc003gaz.2_Missense_Mutation_p.E244Q|MFSD7_uc003gba.2_Missense_Mutation_p.E266Q|MFSD7_uc003gbb.1_Missense_Mutation_p.E298Q	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	363					transmembrane transport	integral to membrane					0						ACCGCCAACTCCATGGCCACG	0.667													0	0	0	0.00308	0	6	70										G	677066	C	G	677066	3	3	8	1	0	0	0	0	1	0	0	0	9537	864	30	1	607	1	MFSD7	4	677066	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		677066	190477210	107	2151										
TACC3	10460	broad.mit.edu	37	chr4	1746465	1746472	+	Frame_Shift_Del	DEL	GGAGCAAG	GGAGCAAG	-													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgaggagatcgcccaggtccGgagcaaggcccaggcggaag							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:1746465_1746472delGGAGCAAG	uc003gdo.2	+	15	2465_2472	c.2357_2364delGGAGCAAG	c.(2356-2364)CGGAGCAAGfs	p.R786fs	TACC3_uc003gdp.2_Frame_Shift_Del_p.R426fs|TACC3_uc010ica.2_Frame_Shift_Del_p.R207fs	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	786_788	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GCCCAGGTCCGGAGCAAGGCCCAGGCGG	0.673																		7	28	---	---								-	1746472	GGAGCAAG	-	1746465	7	5	8	1	0	1	0	1	0	0	0	0	15500	1116	39	0	2411	0	TACC3	4	1746465	Frame_Shift_Del	DEL	GGAGCAAG	TCGA-BT-A20N-01A-11D-A14W-08	1069399	1746465	189407811	108	2152										
PPP2R2C	5522	broad.mit.edu	37	chr4	6325278	6325278	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcccgcttggtgttccgatcGaacatgcggaagaagttgtt	12	9	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:6325278G>T	uc003gjc.2	-	9	1465	c.1095C>A	c.(1093-1095)TTC>TTA	p.F365L	PPP2R2C_uc003gjb.2_Missense_Mutation_p.F348L|PPP2R2C_uc011bwd.1_Missense_Mutation_p.F358L|PPP2R2C_uc011bwe.1_Missense_Mutation_p.F358L|PPP2R2C_uc003gja.2_Missense_Mutation_p.F365L	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	365	WD 6.				signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						TGTTCCGATCGAACATGCGGA	0.622													1	0	3.59834e-05	0.001168	3.85604e-05	6	21										T	6325278	G	T	6325278	3	4	8	1	0	0	0	0	1	0	0	0	12386	1049	37	3	252	3	PPP2R2C	4	6325278	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	4578813	6325278	184828998	109	2153										
BOD1L	259282	broad.mit.edu	37	chr4	13602053	13602053	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cacttgatggttgttgcactGgagataggcaattcgaattc	11	7	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:13602053G>C	uc003gmz.1	-	10	6588	c.6471C>G	c.(6469-6471)TCC>TCG	p.S2157S	BOD1L_uc010idr.1_Silent_p.S1494S	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2157							DNA binding			ovary(5)|breast(1)	6						TTGTTGCACTGGAGATAGGCA	0.498													0	0	0	0.012319	0	21	47										C	13602053	G	C	13602053	2	2	8	1	0	0	0	0	0	0	0	1	1483	1335	47	4		4	BOD1L	4	13602053	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	7276775	13602053	177552223	110	2154										
AFP	174	broad.mit.edu	37	chr4	74320990	74320990	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaaaactcgtgctgctttggGagtttaaattacttcaggta	9	6	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:74320990G>T	uc003hgz.1	+	14	1870	c.1823G>T	c.(1822-1824)GGA>GTA	p.G608V	AFP_uc003hha.1_Intron|AFP_uc011cbg.1_Missense_Mutation_p.G382V	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	608					transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCTGCTTTGGGAGTTTAAATT	0.313									Alpha-Fetoprotein_Hereditary_Persistence_of				1	0	1.75199e-13	0.007291	2.07567e-13	27	57										T	74320990	G	T	74320990	3	4	8	1	0	0	0	0	1	0	0	0	363	1174	41	3	1877	3	AFP	4	74320990	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	60718937	74320990	116833286	111	2155										
THAP9	79725	broad.mit.edu	37	chr4	83839377	83839377	+	Frame_Shift_Del	DEL	T	T	-													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcgaaggaaagacttggcgcTttggacagttcaacgtcagt							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:83839377delT	uc003hnt.2	+	5	2131	c.2012delT	c.(2011-2013)CTTfs	p.L671fs	THAP9_uc003hns.1_Frame_Shift_Del_p.L527fs|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Frame_Shift_Del_p.L388fs	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	671							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				GACTTGGCGCTTTGGACAGTT	0.393																		13	105	---	---								-	83839377	T	-	83839377	7	5	8	1	0	1	0	1	0	0	0	0	15848	1609	56	0	2030	0	THAP9	4	83839377	Frame_Shift_Del	DEL	T	TCGA-BT-A20N-01A-11D-A14W-08	9518387	83839377	107314899	112	2156										
COPS4	51138	broad.mit.edu	37	chr4	83989596	83989596	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttttcccccaataggcggaAaagatagcatctcaaatgat	7	9	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:83989596A>T	uc003hoa.2	+	9	1147	c.1008A>T	c.(1006-1008)GAA>GAT	p.E336D	COPS4_uc003hob.2_Missense_Mutation_p.E336D|COPS4_uc010ijw.2_Missense_Mutation_p.E368D|COPS4_uc010ijx.2_Intron	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	336	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				AATAGGCGGAAAAGATAGCAT	0.328													0	0	0	0.00245	0	13	52										T	83989596	A	T	83989596	3	4	8	1	0	0	0	0	1	0	0	0	3735	11	1	5	1042	5	COPS4	4	83989596	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	150219	83989596	107164680	113	2157										
AFF1	4299	broad.mit.edu	37	chr4	88036209	88036209	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tggtggtccaggaggacagcCgcaaagacagactcccattg	13	11	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:88036209C>G	uc003hqj.3	+	11	2610	c.2203C>G	c.(2203-2205)CGC>GGC	p.R735G	AFF1_uc011ccz.1_Missense_Mutation_p.R742G|AFF1_uc003hqk.3_Missense_Mutation_p.R735G|AFF1_uc011cda.1_Missense_Mutation_p.R373G	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	735						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GGAGGACAGCCGCAAAGACAG	0.607													0	0	0	0.00245	0	10	22										G	88036209	C	G	88036209	3	3	8	1	0	0	0	0	1	0	0	0	356	652	23	4	2287	4	AFF1	4	88036209	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	4046613	88036209	103118067	114	2158										
TACR3	6870	broad.mit.edu	37	chr4	104510983	104510983	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgactggacctggtggtgtcTgcatcgttggggtcaaacac	14	10	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:104510983T>C	uc003hxe.1	-	5	1397	c.1254A>G	c.(1252-1254)GCA>GCG	p.A418A		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	418	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TGGTGGTGTCTGCATCGTTGG	0.517													0	0	0	0.001855	0	13	168										C	104510983	T	C	104510983	2	2	8	1	0	0	0	0	0	0	0	1	15504	1567	55	5		5	TACR3	4	104510983	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	16474774	104510983	86643293	115	2159										
COL25A1	84570	broad.mit.edu	37	chr4	109740467	109740467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcctggctcccctttttcccCcttaacgccacggaatccct	6	19	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:109740467C>T	uc003hze.1	-	35	2395	c.1864G>A	c.(1864-1866)GGG>AGG	p.G622R	COL25A1_uc003hzd.2_Intron	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	622	Extracellular (Potential).|Collagen-like 7.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCTTTTTCCCCCTTAACGCCA	0.463													0	0	0	0.009096	0	3	26										T	109740467	C	T	109740467	3	4	8	1	0	0	0	0	1	0	0	0	3684	623	22	2	112	2	COL25A1	4	109740467	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	5229484	109740467	81413809	116	2160										
KIAA0922	23240	broad.mit.edu	37	chr4	154502664	154502664	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaaacacacaacatttgttaGatcatctctctattgtttac	3	9	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:154502664G>A	uc003inm.3	+	9	896	c.844G>A	c.(844-846)GAT>AAT	p.D282N	KIAA0922_uc010ipp.2_Missense_Mutation_p.D282N|KIAA0922_uc010ipq.2_Missense_Mutation_p.D134N	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	282	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				ACATTTGTTAGATCATCTCTC	0.318													0	0	0	0.008871	0	20	28										A	154502664	G	A	154502664	3	1	8	1	0	0	0	0	1	0	0	0	8201	942	33	1	878	1	KIAA0922	4	154502664	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	44762197	154502664	36651612	117	2161										
FGA	2243	broad.mit.edu	37	chr4	155505643	155505644	+	Missense_Mutation	DNP	CC	CC	AA													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	catagccttcagcctcagagCctacccggaagtgatattct							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:155505643_155505644CC>AA	uc003iod.1	-	6	2291_2292	c.2233_2234GG>TT	c.(2233-2235)GGC>TTC	p.G745F		NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	745	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGCCTCAGAGCCTACCCGGAAG	0.525													0	0	0	0.004672	0	14	44										AA	155505644	CC	AA	155505643	3	1	8	1	0	0	0	0	1	0	0	0	5830	739	26	4	370	4	FGA	4	155505643	Missense_Mutation	DNP	CC	TCGA-BT-A20N-01A-11D-A14W-08	1002979	155505643	35648633	118	2162										
WWC2	80014	broad.mit.edu	37	chr4	184129307	184129307	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaagtcaagttctcacacaaGctgtaagtacagtgtggcta	9	8	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:184129307G>C	uc010irx.2	+	3	625	c.443G>C	c.(442-444)AGC>ACC	p.S148T	WWC2_uc003ivk.3_5'UTR|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_5'Flank	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	148	Potential.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TCTCACACAAGCTGTAAGTAC	0.423													0	0	0	0.009096	0	4	13										C	184129307	G	C	184129307	3	2	8	1	0	0	0	0	1	0	0	0	17409	971	34	4	453	4	WWC2	4	184129307	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	28623664	184129307	7024969	119	2163										
FRG1	2483	broad.mit.edu	37	chr4	190862215	190862215	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aagctcgtgctcaagggaacCaagacgaagaggtgggtcct	14	9	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr4:190862215C>A	uc003izs.2	+	1	242	c.51C>A	c.(49-51)ACC>ACA	p.T17T	uc003izq.2_5'Flank	NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	17	Lys-rich.				rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TCAAGGGAACCAAGACGAAGA	0.632											OREG0016457	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00909568	0.009096	0.00939809	4	15										A	190862215	C	A	190862215	2	1	8	1	0	0	0	0	0	0	0	1	6046	581	21	4		4	FRG1	4	190862215	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6732908	190862215	292061	120	2164										
ZNF622	90441	broad.mit.edu	37	chr5	16465637	16465637	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcccgcactcgctcctggaaGccctcggcggtcactggggc	14	17	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:16465637G>T	uc003jfq.2	-	1	258	c.138C>A	c.(136-138)GGC>GGA	p.G46G		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	46						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						GCTCCTGGAAGCCCTCGGCGG	0.662													1	0	5.9392e-07	0.001168	6.62828e-07	5	169										T	16465637	G	T	16465637	2	4	8	1	0	0	0	0	0	0	0	1	18043	958	34	4		4	ZNF622	5	16465637	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		16465637	164449623	121	2165										
RAI14	26064	broad.mit.edu	37	chr5	34823943	34823943	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tggaggattacaggaagaggAaatctctagaggatgtcaca	13	5	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:34823943A>C	uc003jir.2	+	15	2192	c.1996A>C	c.(1996-1998)AAA>CAA	p.K666Q	RAI14_uc010iur.2_Missense_Mutation_p.K637Q|RAI14_uc011coj.1_Missense_Mutation_p.K666Q|RAI14_uc003jis.2_Missense_Mutation_p.K669Q|RAI14_uc003jit.2_Missense_Mutation_p.K666Q|RAI14_uc011cok.1_Missense_Mutation_p.K658Q	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	666	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CAGGAAGAGGAAATCTCTAGA	0.448													0	0	0	0.00308	0	8	80										C	34823943	A	C	34823943	3	2	8	1	0	0	0	0	1	0	0	0	13008	247	9	5	2115	5	RAI14	5	34823943	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	18358306	34823943	146091317	122	2166										
HCN1	348980	broad.mit.edu	37	chr5	45303809	45303809	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttacccacggctccttctcGtatgatataatctccaggtt	6	12	2	1	rs35229491		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:45303809G>A	uc003jok.2	-	6	1535	c.1510C>T	c.(1510-1512)CGA>TGA	p.R504*		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	504	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GCTCCTTCTCGTATGATATAA	0.403													0	0	0	0.01441	0	50	152										A	45303809	G	A	45303809	4	1	8	1	0	0	0	0	0	1	0	0	6996	1153	40	2	1174	2	HCN1	5	45303809	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	10479866	45303809	135611451	123	2167										
ADAMTS6	11174	broad.mit.edu	37	chr5	64748566	64748566	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	actcaaaatgtaatgttcaaTgtctttgcggccatggtagc	9	8	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:64748566T>G	uc003jtp.2	-	5	1625	c.811A>C	c.(811-813)ATT>CTT	p.I271L	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	271	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TAATGTTCAATGTCTTTGCGG	0.368													0	0	0	0.005524	0	33	28										G	64748566	T	G	64748566	3	3	8	1	0	0	0	0	1	0	0	0	270	1464	51	5	2626	5	ADAMTS6	5	64748566	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	19444757	64748566	116166694	124	2168										
MCCC2	64087	broad.mit.edu	37	chr5	70930791	70930791	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aagtctggagtaagtgaccaCtgggctttggatgatcatca	12	7	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:70930791C>A	uc003kbs.3	+	9	963	c.825C>A	c.(823-825)CAC>CAA	p.H275Q	MCCC2_uc010iyv.1_Missense_Mutation_p.H275Q|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.H144Q	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	275	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	TAAGTGACCACTGGGCTTTGG	0.368													1	0	9.45814e-24	0.004878	1.16853e-23	36	28										A	70930791	C	A	70930791	3	1	8	1	0	0	0	0	1	0	0	0	9375	564	20	4	859	4	MCCC2	5	70930791	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6182225	70930791	109984469	125	2169										
ARRDC3	57561	broad.mit.edu	37	chr5	90669643	90669643	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctctgttaccacttctgcaTagctgggtggtgctgaagga	12	10	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:90669643T>C	uc003kjz.2	-	7	1286	c.1046A>G	c.(1045-1047)TAT>TGT	p.Y349C		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	349					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		CACTTCTGCATAGCTGGGTGG	0.428													0	0	0	0.004289	0	38	26										C	90669643	T	C	90669643	3	2	8	1	0	0	0	0	1	0	0	0	984	1406	49	5	206	5	ARRDC3	5	90669643	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	19738852	90669643	90245617	126	2170										
SLC12A2	6558	broad.mit.edu	37	chr5	127471428	127471428	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tggtgatcctacttcttgctAttggtgatttcgtcatagga	10	7	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:127471428A>T	uc003kus.2	+	7	1500	c.1336A>T	c.(1336-1338)ATT>TTT	p.I446F	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.I446F	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	446	Helical; (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACTTCTTGCTATTGGTGATTT	0.264													0	0	0	0.000602	0	3	55										T	127471428	A	T	127471428	3	4	8	1	0	0	0	0	1	0	0	0	14383	449	16	5	1362	5	SLC12A2	5	127471428	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	36801785	127471428	53443832	127	2171										
ETF1	2107	broad.mit.edu	37	chr5	137849377	137849377	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tccaaacttgctatcatctgAaagtagtgctgtaagagcct	8	9	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:137849377A>C	uc003ldc.3	-	5	586	c.421T>G	c.(421-423)TCA>GCA	p.S141A	ETF1_uc011cyv.1_Missense_Mutation_p.S127A|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Missense_Mutation_p.S108A|ETF1_uc010jey.1_5'UTR	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	141					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CTATCATCTGAAAGTAGTGCT	0.403													0	0	0	0.00333	0	22	19										C	137849377	A	C	137849377	3	2	8	1	0	0	0	0	1	0	0	0	5268	246	9	5	920	5	ETF1	5	137849377	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	10377949	137849377	43065883	128	2172										
PCDHB5	26167	broad.mit.edu	37	chr5	140517289	140517289	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggtgtgtttgaccggagactCaggggccggcgagttcaagt	17	8	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:140517289C>G	uc003liq.2	+	1	2490	c.2273C>G	c.(2272-2274)TCA>TGA	p.S758*		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	758	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCGGAGACTCAGGGGCCGGC	0.592													0	0	0	0.00278	0	24	108										G	140517289	C	G	140517289	4	3	8	1	0	0	0	0	0	1	0	0	11545	838	29	1	2275	1	PCDHB5	5	140517289	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2667912	140517289	40397971	129	2173										
PCDHGB3	56102	broad.mit.edu	37	chr5	140751625	140751625	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcgcgtgttggtggacgaccGcaacgacaatgcaccgctgg	15	12	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:140751625G>A	uc003ljw.1	+	1	1664	c.1664G>A	c.(1663-1665)CGC>CAC	p.R555H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.R555H|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	555	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGACGACCGCAACGACAAT	0.667													0	0	0	0.009096	0	3	30										A	140751625	G	A	140751625	3	1	8	1	0	0	0	0	1	0	0	0	11564	1087	38	2	1666	2	PCDHGB3	5	140751625	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	234336	140751625	40163635	130	2174										
FBXW11	23291	broad.mit.edu	37	chr5	171318553	171318553	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cacctttactattttcagagCggcactgaatcctctgcaag	7	12	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:171318553C>T	uc003mbm.1	-	6	1078	c.707G>A	c.(706-708)CGC>CAC	p.R236H	FBXW11_uc011dey.1_Missense_Mutation_p.R204H|FBXW11_uc003mbl.1_Missense_Mutation_p.R223H|FBXW11_uc003mbn.1_Missense_Mutation_p.R202H	NM_012300	NP_036432	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11 isoform	236					cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.N260_I262(1)|p.R236C(1)		ovary(1)|breast(1)	2	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATTTTCAGAGCGGCACTGAAT	0.378													0	0	0	0.000602	0	5	44										T	171318553	C	T	171318553	3	4	8	1	0	0	0	0	1	0	0	0	5764	768	27	2	949	2	FBXW11	5	171318553	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	30566928	171318553	9596707	131	2175										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171765673	171765674	+	Frame_Shift_Ins	INS	-	-	A													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcgtgtcatcctggccccccINSaaagagttggagagaaaagg							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:171765673_171765674insA	uc003mbr.2	-	13	2606_2607	c.2435_2436insT	c.(2434-2436)TTGfs	p.L812fs		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	812					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTGGCCCCCCAAAGAGTTGGA	0.609																		17	15	---	---								A	171765674	-	A	171765673	7	5	8	1	0	1	1	0	0	0	0	0	14257	593	21	0	303	0	SH3PXD2B	5	171765673	Frame_Shift_Ins	INS	-	TCGA-BT-A20N-01A-11D-A14W-08	447120	171765673	9149587	132	2176										
FGFR4	2264	broad.mit.edu	37	chr5	176518005	176518005	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agtacctgcggggaacaccgTcaagttccgctgtccagctg	12	13	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:176518005T>A	uc003mfl.2	+	5	670	c.503T>A	c.(502-504)GTC>GAC	p.V168D	FGFR4_uc003mfm.2_Missense_Mutation_p.V168D|FGFR4_uc011dfu.1_Missense_Mutation_p.V168D|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_3'UTR|FGFR4_uc011dfw.1_Missense_Mutation_p.V168D|FGFR4_uc003mfo.2_Missense_Mutation_p.V168D	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	168	Extracellular (Potential).|Ig-like C2-type 2.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GGGAACACCGTCAAGTTCCGC	0.612										TSP Lung(9;0.080)			0	0	0	0.00245	0	14	11										A	176518005	T	A	176518005	3	1	8	1	0	0	0	0	1	0	0	0	5868	1667	58	5	517	5	FGFR4	5	176518005	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	4752332	176518005	4397255	133	2177										
ZNF354C	30832	broad.mit.edu	37	chr5	178503483	178503483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggatgtggccgtgttcttcaGccaggacgagtggttgcacc	15	10	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr5:178503483G>A	uc003mju.2	+	3	180	c.65G>A	c.(64-66)AGC>AAC	p.S22N		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		GTGTTCTTCAGCCAGGACGAG	0.542													0	0	0	0.001855	0	13	42										A	178503483	G	A	178503483	3	1	8	1	0	0	0	0	1	0	0	0	17863	971	34	2	71	2	ZNF354C	5	178503483	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1985478	178503483	2411777	134	2178										
FAM50B	26240	broad.mit.edu	37	chr6	3850672	3850672	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtgcgcaagggcaacacggtGcagcagttcctgaagaaggc	15	10	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:3850672G>A	uc003mvu.2	+	2	739	c.627G>A	c.(625-627)GTG>GTA	p.V209V		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	209						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GCAACACGGTGCAGCAGTTCC	0.647													0	0	0	0.013726	0	35	53										A	3850672	G	A	3850672	2	1	8	1	0	0	0	0	0	0	0	1	5578	1306	46	2		2	FAM50B	6	3850672	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		3850672	167264395	135	2179										
NKAPL	222698	broad.mit.edu	37	chr6	28228103	28228103	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtaaaagctggaaagcgaatCccacgaagaggtgaaattgg	13	6	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:28228103C>A	uc003nkt.2	+	1	1006	c.954C>A	c.(952-954)ATC>ATA	p.I318I	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	318										upper_aerodigestive_tract(1)|ovary(1)	2						GAAAGCGAATCCCACGAAGAG	0.463													1	0	3.59834e-05	0.001168	3.85604e-05	6	105										A	28228103	C	A	28228103	2	1	8	1	0	0	0	0	0	0	0	1	10440	845	30	3		3	NKAPL	6	28228103	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	24377431	28228103	142886964	136	2180										
ZFP57	346171	broad.mit.edu	37	chr6	29640795	29640796	+	Missense_Mutation	DNP	GG	GG	CT													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggatctggcatcctgacagaGggttccagtgatgggtgcct							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:29640795_29640796GG>CT	uc011dlw.1	-	4	1243_1244	c.1092_1093CC>AG	c.(1090-1095)ACCCTC>ACAGTC	p.L365V	ZFP57_uc003nnl.3_Missense_Mutation_p.L345V	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	281					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TCCTGACAGAGGGTTCCAGTGA	0.49													0	0	0	0.004672	0	124	88										CT	29640796	GG	CT	29640795	3	2	8	1	0	0	0	0	1	0	0	0	17648	1000	35	4	521	4	ZFP57	6	29640795	Missense_Mutation	DNP	GG	TCGA-BT-A20N-01A-11D-A14W-08	1412692	29640795	141474272	137	2181										
TRIM10	10107	broad.mit.edu	37	chr6	30128418	30128418	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccaccacgttagccagctgcCagttgggccggaagctccca	11	16	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:30128418C>T	uc003npo.3	-	1	294	c.218G>A	c.(217-219)TGG>TAG	p.W73*	TRIM10_uc003npn.2_Nonsense_Mutation_p.W73*|TRIM15_uc010jrx.2_5'Flank	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	73						cytoplasm	zinc ion binding				0						AGCCAGCTGCCAGTTGGGCCG	0.592													0	0	0	0.01441	0	102	60										T	30128418	C	T	30128418	4	4	8	1	0	0	0	0	0	1	0	0	16483	595	21	2	1343	2	TRIM10	6	30128418	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	487623	30128418	140986649	138	2182										
POU5F1	5460	broad.mit.edu	37	chr6	31133762	31133762	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtatatcccagggtgatcctCttctgcttcaggagcttggc	11	11	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:31133762C>G	uc003nsv.2	-	2	522	c.468G>C	c.(466-468)AAG>AAC	p.K156N	POU5F1_uc003nsu.2_Missense_Mutation_p.K61N|uc011dnf.1_RNA	NM_002701	NP_002692	Q01860	PO5F1_HUMAN	POU domain, class 5, transcription factor 1	156	POU-specific.				anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	skin(7)|salivary_gland(2)|bone(2)|lung(1)|ovary(1)	13						GGGTGATCCTCTTCTGCTTCA	0.498			T	EWSR1	sarcoma								0	0	0	0.014323	0	21	13										G	31133762	C	G	31133762	3	3	8	1	0	0	0	0	1	0	0	0	12281	912	32	1	630	1	POU5F1	6	31133762	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1005344	31133762	139981305	139	2183										
C6orf222	389384	broad.mit.edu	37	chr6	36291124	36291126	+	Missense_Mutation	TNP	TGG	TGG	CTT													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aacacacaggggcagaaagcTgggcctcttgggtcgtcggg							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:36291124_36291126TGG>CTT	uc003oly.2	-	8	1593_1595	c.1415_1417CCA>AAG	c.(1414-1419)CCCAGC>CAAGGC	p.472_473PS>QG		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	472_473										skin(2)|ovary(1)|breast(1)	4						GGCAGAAAGCTGGGCCTCTTGGG	0.616													0	0	0	0.004672	0	21	64										CTT	36291126	TGG	CTT	36291124	3	2	8	1	0	0	0	0	1	0	0	0	2356	1580	55	5	561	5	C6orf222	6	36291124	Missense_Mutation	TNP	TGG	TCGA-BT-A20N-01A-11D-A14W-08	5157362	36291124	134823943	140	2184										
TRERF1	55809	broad.mit.edu	37	chr6	42236926	42236926	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtgtaagacaccgctggtaaGcttctgggtccggatctcgc	13	11	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:42236926G>T	uc003osd.2	-	5	966	c.403C>A	c.(403-405)CTT>ATT	p.L135I	TRERF1_uc011duq.1_Missense_Mutation_p.L135I|TRERF1_uc003osb.2_5'UTR|TRERF1_uc003osc.2_5'UTR|TRERF1_uc003ose.2_Missense_Mutation_p.L135I	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	135					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCGCTGGTAAGCTTCTGGGTC	0.562													1	0	2.18419e-29	0.01441	2.71512e-29	58	170										T	42236926	G	T	42236926	3	4	8	1	0	0	0	0	1	0	0	0	16472	971	34	4	3255	4	TRERF1	6	42236926	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	5945802	42236926	128878141	141	2185										
KHDRBS2	202559	broad.mit.edu	37	chr6	62887182	62887182	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atacttcttttcttcgtcttCcttttttccatcagaacctt	2	12	4	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:62887182C>A	uc003peg.2	-	2	374	c.127G>T	c.(127-129)GAA>TAA	p.E43*		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCTTCGTCTTCCTTTTTTCCA	0.343													1	0	0.000157383	0.00308	0.000166884	7	8										A	62887182	C	A	62887182	4	1	8	1	0	0	0	0	0	1	0	0	8147	864	30	3	954	3	KHDRBS2	6	62887182	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	20650256	62887182	108227885	142	2186										
PHIP	55023	broad.mit.edu	37	chr6	79650578	79650578	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgaccttgatttctagttctCatgtggggttcagagccttt	10	9	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:79650578C>G	uc003pir.2	-	40	5524	c.5298G>C	c.(5296-5298)ATG>ATC	p.M1766I	PHIP_uc003piq.2_Missense_Mutation_p.M790I|PHIP_uc011dyp.1_Missense_Mutation_p.M1765I|IRAK1BP1_uc010kbg.1_Intron|PHIP_uc003pio.3_Missense_Mutation_p.M652I	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1766					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TTCTAGTTCTCATGTGGGGTT	0.408													0	0	0	0.01441	0	96	661										G	79650578	C	G	79650578	3	3	8	1	0	0	0	0	1	0	0	0	11842	826	29	1	171	1	PHIP	6	79650578	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	16763396	79650578	91464489	143	2187										
ORC3L	23595	broad.mit.edu	37	chr6	88331710	88331710	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaaaagcaagttgcgctcttGaccaatgagagatatttgaa	10	6	1	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:88331710G>C	uc003pmh.2	+	11	1208	c.1164G>C	c.(1162-1164)TTG>TTC	p.L388F	ORC3L_uc011dzl.1_Missense_Mutation_p.L388F|ORC3L_uc011dzm.1_Missense_Mutation_p.L388F|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Missense_Mutation_p.L388F|ORC3L_uc003pmi.2_Missense_Mutation_p.L350F|ORC3L_uc011dzo.1_Missense_Mutation_p.L245F|ORC3L_uc011dzp.1_Missense_Mutation_p.L245F	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	388					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		TTGCGCTCTTGACCAATGAGA	0.313													0	0	0	0.010729	0	10	57										C	88331710	G	C	88331710	3	2	8	1	0	0	0	0	1	0	0	0	11263	1281	45	1	1206	1	ORC3L	6	88331710	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	8681132	88331710	82783357	144	2188										
MDN1	23195	broad.mit.edu	37	chr6	90354787	90354787	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacaaagatatttgcattccGggcagcctgaactgctgcca	10	11	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:90354787G>A	uc003pnn.1	-	101	16665	c.16549C>T	c.(16549-16551)CGG>TGG	p.R5517W		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5517	VWFA.				protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTGCATTCCGGGCAGCCTGA	0.483													0	0	0	0.001168	0	6	48										A	90354787	G	A	90354787	3	1	8	1	0	0	0	0	1	0	0	0	9415	1115	39	2	249	2	MDN1	6	90354787	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2023077	90354787	80760280	145	2189										
HSF2	3298	broad.mit.edu	37	chr6	122733619	122733619	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcaagctttgtgaggcaactGaatatgtgtgagtatggaca	13	5	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:122733619G>A	uc003pyu.2	+	2	382	c.195G>A	c.(193-195)CTG>CTA	p.L65L	HSF2_uc003pyt.3_Silent_p.L65L|HSF2_uc003pyv.2_Silent_p.L65L	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	65	By similarity.				response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TGAGGCAACTGAATATGTGTG	0.373													0	0	0	0.01441	0	47	39										A	122733619	G	A	122733619	2	1	8	1	0	0	0	0	0	0	0	1	7396	1277	45	1		1	HSF2	6	122733619	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	32378832	122733619	48381448	146	2190										
C6orf174	387104	broad.mit.edu	37	chr6	127796469	127796469	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaatgggctcctcggcgccgCggtcgtccgcagacttgggc	15	14	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr6:127796469C>A	uc003qbd.2	-	6	3567	c.2702G>T	c.(2701-2703)CGC>CTC	p.R901L	C6orf174_uc003qbc.2_5'UTR	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	901						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CTCGGCGCCGCGGTCGTCCGC	0.667													1	0	3.59834e-05	0.001168	3.85604e-05	4	68										A	127796469	C	A	127796469	3	1	8	1	0	0	0	0	1	0	0	0	2345	768	27	4	149	4	C6orf174	6	127796469	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	5062850	127796469	43318598	147	2191										
NUDT1	4521	broad.mit.edu	37	chr7	2284269	2284269	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcctcagcgagttctcctGggcatgaaaaagcgaggctt	12	11	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:2284269G>C	uc003slp.1	+	3	231	c.129G>C	c.(127-129)CTG>CTC	p.L43L	FTSJ2_uc003slk.2_5'Flank|FTSJ2_uc003sll.2_5'Flank|FTSJ2_uc003slm.2_5'Flank|FTSJ2_uc003sln.2_5'Flank|FTSJ2_uc003slo.2_5'Flank|NUDT1_uc003slq.1_Silent_p.L20L|NUDT1_uc003slr.1_Silent_p.L20L|NUDT1_uc003sls.1_Silent_p.L43L|NUDT1_uc003slt.1_Silent_p.L20L|NUDT1_uc003slu.1_Silent_p.L43L|NUDT1_uc003slv.1_Silent_p.L20L	NM_198949	NP_945187	P36639	8ODP_HUMAN	nudix-type motif 1 isoform p22	61	Nudix hydrolase.				DNA protection|DNA repair|response to oxidative stress	cytoplasm	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|GTPase activity|metal ion binding|protein binding				0		Ovarian(82;0.0253)|Melanoma(862;0.155)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.8e-14)|BRCA - Breast invasive adenocarcinoma(126;0.15)		GAGTTCTCCTGGGCATGAAAA	0.602								Direct_reversal_of_damage|Modulation_of_nucleotide_pools					0	0	0	0.004289	0	35	35										C	2284269	G	C	2284269	2	2	8	1	0	0	0	0	0	0	0	1	10725	1335	47	4		4	NUDT1	7	2284269	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		2284269	156854394	148	2192										
OSBPL3	26031	broad.mit.edu	37	chr7	24849496	24849503	+	Frame_Shift_Del	DEL	CCGATGAA	CCGATGAA	-													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcatgccatttcccaaacagCcgatgaaccgcttttccact							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:24849496_24849503delCCGATGAA	uc003sxf.2	-	20	2645_2652	c.2240_2247delTTCATCGG	c.(2239-2247)GTTCATCGGfs	p.V747fs	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Frame_Shift_Del_p.V711fs|OSBPL3_uc003sxh.2_Frame_Shift_Del_p.V716fs|OSBPL3_uc003sxi.2_Frame_Shift_Del_p.V680fs	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	747_749					lipid transport		lipid binding|protein binding			skin(1)	1						TCCCAAACAGCCGATGAACCGCTTTTCC	0.5																		68	160	---	---								-	24849503	CCGATGAA	-	24849496	7	5	8	1	0	1	0	1	0	0	0	0	11279	726	26	0	432	0	OSBPL3	7	24849496	Frame_Shift_Del	DEL	CCGATGAA	TCGA-BT-A20N-01A-11D-A14W-08	22565227	24849496	134289167	149	2193										
AOAH	313	broad.mit.edu	37	chr7	36633960	36633960	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cttacccaacagtggagtccAgaaatcctgtagcaccagag	9	12	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:36633960A>C	uc003tfh.3	-	12	1324	c.923T>G	c.(922-924)CTG>CGG	p.L308R	AOAH_uc010kxf.2_Missense_Mutation_p.L308R|AOAH_uc011kba.1_Missense_Mutation_p.L276R	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	308					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						AGTGGAGTCCAGAAATCCTGT	0.448													0	0	0	0.009096	0	4	86										C	36633960	A	C	36633960	3	2	8	1	0	0	0	0	1	0	0	0	726	188	7	5	1185	5	AOAH	7	36633960	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	11784464	36633960	122504703	150	2194										
GPR141	353345	broad.mit.edu	37	chr7	37780823	37780823	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttgagtgtaacagcaattagCtgctatgatttgcttctctt	8	7	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:37780823C>G	uc003tfm.1	+	1	828	c.828C>G	c.(826-828)AGC>AGG	p.S276R	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	276	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						CAGCAATTAGCTGCTATGATT	0.378													0	0	0	0.008291	0	10	152										G	37780823	C	G	37780823	3	3	8	1	0	0	0	0	1	0	0	0	6649	796	28	4	830	4	GPR141	7	37780823	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1146863	37780823	121357840	151	2195										
H2AFV	94239	broad.mit.edu	37	chr7	44880564	44880564	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtggcacccacccttccatgGcttgtggtgcgagtcttcaa	11	13	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:44880564G>A	uc003tma.2	-	3	284	c.129C>T	c.(127-129)AGC>AGT	p.S43S	H2AFV_uc003tlz.2_Silent_p.S43S|H2AFV_uc003tmb.2_Intron|H2AFV_uc003tmc.2_Silent_p.S43S|H2AFV_uc003tmd.2_Silent_p.S17S	NM_012412	NP_036544	Q71UI9	H2AV_HUMAN	H2A histone family, member V isoform 1	43					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCCTTCCATGGCTTGTGGTGC	0.512													0	0	0	0.000602	0	5	58										A	44880564	G	A	44880564	2	1	8	1	0	0	0	0	0	0	0	1	6927	1194	42	2		2	H2AFV	7	44880564	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	7099741	44880564	114258099	152	2196										
ABCA13	154664	broad.mit.edu	37	chr7	48280473	48280473	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgaatttgtaggtgtttgttCagtggcaacagggtagcctg	14	6	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:48280473C>T	uc003toq.2	+	10	1097	c.1072C>T	c.(1072-1074)CAG>TAG	p.Q358*	ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	358					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGTGTTTGTTCAGTGGCAACA	0.408													0	0	0	0.00333	0	23	51										T	48280473	C	T	48280473	4	4	8	1	0	0	0	0	0	1	0	0	31	827	29	1	939	1	ABCA13	7	48280473	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3399909	48280473	110858190	153	2197										
POM121	9883	broad.mit.edu	37	chr7	72412672	72412672	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaacacagaacacctcacctTccagccctgccgcccctgct	6	20	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:72412672T>C	uc003twk.2	+	11	2140	c.2140T>C	c.(2140-2142)TCC>CCC	p.S714P	POM121_uc003twj.2_Missense_Mutation_p.S449P|POM121_uc010lam.1_Missense_Mutation_p.S449P	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	714	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CACCTCACCTTCCAGCCCTGC	0.607													0	0	0	0.00308	0	6	76										C	72412672	T	C	72412672	3	2	8	1	0	0	0	0	1	0	0	0	12239	1783	62	5	1383	5	POM121	7	72412672	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	24132199	72412672	86725991	154	2198										
PILRA	29992	broad.mit.edu	37	chr7	99987517	99987517	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcatctctccccagctgtcaCgaccaccacccagaggccca	6	20	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:99987517C>T	uc003uuo.1	+	3	673	c.461C>T	c.(460-462)ACG>ATG	p.T154M	PILRA_uc011kjo.1_Intron|PILRA_uc003uup.1_Intron|PILRA_uc003uuq.1_Intron	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	154	Extracellular (Potential).				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCAGCTGTCACGACCACCACC	0.612													0	0	0	0.00308	0	7	62										T	99987517	C	T	99987517	3	4	8	1	0	0	0	0	1	0	0	0	11925	536	19	2	471	2	PILRA	7	99987517	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	27574845	99987517	59151146	155	2199										
LMOD2	442721	broad.mit.edu	37	chr7	123296034	123296034	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaccatgtctacctttggctAccgaagaggactcagtaaat	9	10	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr7:123296034A>G	uc003vky.2	+	1	174	c.17A>G	c.(16-18)TAC>TGC	p.Y6C		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	6	Tropomyosin-binding (By similarity).					cytoskeleton	actin binding|tropomyosin binding				0						ACCTTTGGCTACCGAAGAGGA	0.557													0	0	0	0.009096	0	3	6										G	123296034	A	G	123296034	3	3	8	1	0	0	0	0	1	0	0	0	8857	391	14	5	19	5	LMOD2	7	123296034	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	23308517	123296034	35842629	156	2200										
TEX15	56154	broad.mit.edu	37	chr8	30704189	30704189	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctgtcgggctgaatcctggcCtaaatatattagtaatttta	8	7	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:30704189C>T	uc003xil.2	-	1	2345	c.2345G>A	c.(2344-2346)AGG>AAG	p.R782K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	782										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GAATCCTGGCCTAAATATATT	0.353													0	0	0	0.004482	0	8	85										T	30704189	C	T	30704189	3	4	8	1	0	0	0	0	1	0	0	0	15776	681	24	2	6040	2	TEX15	8	30704189	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		30704189	115659833	157	2201										
ADAM9	8754	broad.mit.edu	37	chr8	38948794	38948794	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcaggtcagatggcaaaaatCaagcaaacccttctagacag	8	10	4	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:38948794C>G	uc003xmr.2	+	20	2305	c.2227C>G	c.(2227-2229)CAA>GAA	p.Q743E	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA|ADAM9_uc003xms.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	743	Cytoplasmic (Potential).			Missing (in Ref. 2; no nucleotide entry).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			TGGCAAAAATCAAGCAAACCC	0.338													0	0	0	0.001855	0	14	149										G	38948794	C	G	38948794	3	3	8	1	0	0	0	0	1	0	0	0	253	827	29	1	2305	1	ADAM9	8	38948794	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	8244605	38948794	107415228	158	2202										
MOS	4342	broad.mit.edu	37	chr8	57025924	57025924	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcctgctcactgatcaagatGttcgcgggcttcaggtccaa	10	12	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:57025924G>T	uc011leb.1	-	1	618	c.618C>A	c.(616-618)AAC>AAA	p.N206K		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	206	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			TGATCAAGATGTTCGCGGGCT	0.483													1	0	3.41278e-10	0.00499	3.98487e-10	18	32										T	57025924	G	T	57025924	3	4	8	1	0	0	0	0	1	0	0	0	9712	1368	48	4	425	4	MOS	8	57025924	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	18077130	57025924	89338098	159	2203										
NSMAF	8439	broad.mit.edu	37	chr8	59503463	59503463	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tacttctttgtagcatttttGattctttagaaaacatcttc	4	7	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:59503463G>A	uc003xtt.2	-	24	2196	c.1982C>T	c.(1981-1983)TCA>TTA	p.S661L	NSMAF_uc011lee.1_Missense_Mutation_p.S692L	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	661					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TAGCATTTTTGATTCTTTAGA	0.289													0	0	0	0.010729	0	11	22										A	59503463	G	A	59503463	3	1	8	1	0	0	0	0	1	0	0	0	10674	1294	45	1	803	1	NSMAF	8	59503463	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2477539	59503463	86860559	160	2204										
CSPP1	79848	broad.mit.edu	37	chr8	68049786	68049786	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atgagaacatataatccctgGggaaaaggtggaggtggtgc	15	5	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:68049786G>T	uc003xxi.2	+	17	2044	c.2013G>T	c.(2011-2013)TGG>TGT	p.W671C	CSPP1_uc003xxg.1_Missense_Mutation_p.W663C|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.W636C|CSPP1_uc003xxk.2_Missense_Mutation_p.W342C	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	671						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			ATAATCCCTGGGGAAAAGGTG	0.348													1	0	9.70103e-10	0.008291	1.12298e-09	11	21										T	68049786	G	T	68049786	3	4	8	1	0	0	0	0	1	0	0	0	3962	1241	43	4	2079	4	CSPP1	8	68049786	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	8546323	68049786	78314236	161	2205										
RAD54B	25788	broad.mit.edu	37	chr8	95392549	95392549	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agagattggtgtttgtccatCaagtcttgtataagcatatc	9	6	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:95392549C>T	uc003ygk.2	-	12	2169	c.2071G>A	c.(2071-2073)GAT>AAT	p.D691N	RAD54B_uc010may.1_Missense_Mutation_p.D498N	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GTTTGTCCATCAAGTCTTGTA	0.363								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.004656	0	23	39										T	95392549	C	T	95392549	3	4	8	1	0	0	0	0	1	0	0	0	12992	826	29	1	677	1	RAD54B	8	95392549	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	27342763	95392549	50971473	162	2206										
RAD54B	25788	broad.mit.edu	37	chr8	95392597	95392609	+	Frame_Shift_Del	DEL	TGTTCAAGGTTTG	TGTTCAAGGTTTG	-													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cttacatacttcttgtaaaaTgttcaaggtttgtgtatagt					rs76782918		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:95392597_95392609delTGTTCAAGGTTTG	uc003ygk.2	-	12	2109_2121	c.2011_2023delCAAACCTTGAACA	c.(2011-2025)CAAACCTTGAACATTfs	p.Q671fs	RAD54B_uc010may.1_Frame_Shift_Del_p.Q478fs	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment_28					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TCTTGTAAAATGTTCAAGGTTTGTGTATAGTTG	0.347								Direct_reversal_of_damage|Homologous_recombination										11	56	---	---								-	95392609	TGTTCAAGGTTTG	-	95392597	7	5	8	1	0	1	0	1	0	0	0	0	12992	1464	51	0	725	0	RAD54B	8	95392597	Frame_Shift_Del	DEL	TGTTCAAGGTTTG	TCGA-BT-A20N-01A-11D-A14W-08	48	95392597	50971425	163	2207										
HRSP12	10247	broad.mit.edu	37	chr8	99118512	99118512	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttgctcaccgttagtgaagtCacagcctgcagctttcagaa	9	11	3	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:99118512C>T	uc003yii.1	-	3	308	c.214G>A	c.(214-216)GAC>AAC	p.D72N		NM_005836	NP_005827	P52758	UK114_HUMAN	heat-responsive protein 12	72					regulation of translational termination	nucleus	endonuclease activity			ovary(1)	1	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			TTAGTGAAGTCACAGCCTGCA	0.363													0	0	0	0.008291	0	11	89										T	99118512	C	T	99118512	3	4	8	1	0	0	0	0	1	0	0	0	7360	826	29	1	215	1	HRSP12	8	99118512	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3725915	99118512	47245510	164	2208										
OXR1	55074	broad.mit.edu	37	chr8	107718630	107718631	+	Missense_Mutation	DNP	GA	GA	TG													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agatatagatcagctatcagGaagggacttctgccattcaa							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:107718630_107718631GA>TG	uc011lht.1	+	8	983_984	c.884_885GA>TG	c.(883-885)GGA>GTG	p.G295V	OXR1_uc003ymf.2_Missense_Mutation_p.G294V|OXR1_uc011lhu.1_Missense_Mutation_p.G287V|OXR1_uc010mcg.2_Intron|OXR1_uc010mch.2_5'UTR|OXR1_uc003ymg.1_Missense_Mutation_p.G227V|OXR1_uc003ymi.1_Missense_Mutation_p.G206V	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	295					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			CAGCTATCAGGAAGGGACTTCT	0.351													0	0	0	0.004672	0	9	62										TG	107718631	GA	TG	107718630	3	4	8	1	0	0	0	0	1	0	0	0	11334	1174	41	3	1114	3	OXR1	8	107718630	Missense_Mutation	DNP	GA	TCGA-BT-A20N-01A-11D-A14W-08	8600118	107718630	38645392	165	2209										
TG	7038	broad.mit.edu	37	chr8	133941430	133941430	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gagttccccgtgatgcagtgCttgacaggtgaggagtggtg	17	7	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:133941430C>T	uc003ytw.2	+	23	4850	c.4809C>T	c.(4807-4809)TGC>TGT	p.C1603C	TG_uc010mdw.2_Silent_p.C362C|TG_uc011ljb.1_Silent_p.C36C|TG_uc003ytx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1603	Type IIIA.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGATGCAGTGCTTGACAGGTG	0.468													0	0	0	0.004672	0	3	87										T	133941430	C	T	133941430	2	4	8	1	0	0	0	0	0	0	0	1	15810	805	28	2		2	TG	8	133941430	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	26222800	133941430	12422592	166	2210										
COL22A1	169044	broad.mit.edu	37	chr8	139833571	139833571	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tcattgacccgagaacctcgGaagaccaccctgacagcatc	8	15	1	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr8:139833571G>A	uc003yvd.2	-	7	1500	c.1053C>T	c.(1051-1053)TTC>TTT	p.F351F		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	351	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAGAACCTCGGAAGACCACCC	0.582										HNSCC(7;0.00092)			0	0	0	0.001984	0	7	86										A	139833571	G	A	139833571	2	1	8	1	0	0	0	0	0	0	0	1	3681	1165	41	1		1	COL22A1	8	139833571	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	5892141	139833571	6530451	167	2211										
DNAI1	27019	broad.mit.edu	37	chr9	34514409	34514409	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagtgctctaaatcctactcCagccaattcctcgacaccta	4	16	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:34514409C>T	uc003zum.2	+	17	1780	c.1587C>T	c.(1585-1587)TCC>TCT	p.S529S		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	529					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		AATCCTACTCCAGCCAATTCC	0.567									Kartagener_syndrome				0	0	0	0.01441	0	82	63										T	34514409	C	T	34514409	2	4	8	1	0	0	0	0	0	0	0	1	4609	581	21	2		2	DNAI1	9	34514409	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		34514409	106699022	168	2212										
GNE	10020	broad.mit.edu	37	chr9	36276944	36276944	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ataaccataggtttccatccCgaagcacgagctctgtaccc	7	14	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:36276944C>T	uc010mlj.2	-	1	98	c.96G>A	c.(94-96)TCG>TCA	p.S32S	CLTA_uc003zzf.1_Intron|GNE_uc010mli.2_5'UTR	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	Error:Variant_position_missing_in_Q9Y223_after_alignment					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			GTTTCCATCCCGAAGCACGAG	0.433													0	0	0	0.01441	0	46	68										T	36276944	C	T	36276944	2	4	8	1	0	0	0	0	0	0	0	1	6522	667	23	2		2	GNE	9	36276944	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1762535	36276944	104936487	169	2213										
RORB	6096	broad.mit.edu	37	chr9	77257389	77257389	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcctgtatgctgaggtgcagAagcaccagcagcggctgcag	15	11	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:77257389A>G	uc004aji.2	+	4	377	c.328A>G	c.(328-330)AAG>GAG	p.K110E	RORB_uc004ajh.2_Missense_Mutation_p.K99E	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	110	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						TGAGGTgcagaagcaccagca	0.413													0	0	0	0.00308	0	7	37										G	77257389	A	G	77257389	3	3	8	1	0	0	0	0	1	0	0	0	13529	247	9	5	309	5	RORB	9	77257389	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	40980445	77257389	63956042	170	2214										
NAA35	60560	broad.mit.edu	37	chr9	88635862	88635862	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggttatgaagttattggcagGaggacacaaaaaggaatcta	12	4	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:88635862G>T	uc004aoi.3	+	22	2233	c.2096G>T	c.(2095-2097)GGA>GTA	p.G699V	NAA35_uc004aoj.3_Missense_Mutation_p.G699V	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	699					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						TTATTGGCAGGAGGACACAAA	0.313													1	0	2.56e-06	0.009096	2.81809e-06	3	27										T	88635862	G	T	88635862	3	4	8	1	0	0	0	0	1	0	0	0	10123	1174	41	3	2178	3	NAA35	9	88635862	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	11378473	88635862	52577569	171	2215										
ECM2	1842	broad.mit.edu	37	chr9	95285103	95285103	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	attttttccaaagtcagtttGaaaaatgataagcagaaaaa	6	4	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:95285103G>C	uc004ash.2	-	2	111	c.46C>G	c.(46-48)CAA>GAA	p.Q16E	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.Q16E|ECM2_uc011lty.1_Missense_Mutation_p.Q16E|ECM2_uc004asg.2_Missense_Mutation_p.Q16E|ECM2_uc011ltz.1_Missense_Mutation_p.Q16E|ECM2_uc004asi.2_Missense_Mutation_p.Q16E	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	16					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						AAGTCAGTTTGAAAAATGATA	0.338													0	0	0	0.010504	0	21	18										C	95285103	G	C	95285103	3	2	8	1	0	0	0	0	1	0	0	0	4898	1299	45	1	2089	1	ECM2	9	95285103	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6649241	95285103	45928328	172	2216										
TNFSF8	944	broad.mit.edu	37	chr9	117692469	117692469	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agtggctgtggtcaaatagaAatagctgcggctcgtggtcc	14	8	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:117692469A>C	uc004bji.1	-	1	302	c.115T>G	c.(115-117)TTC>GTC	p.F39V		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	39	Helical; Signal-anchor for type II membrane protein; (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GTCAAATAGAAATAGCTGCGG	0.592													0	0	0	0.001984	0	6	65										C	117692469	A	C	117692469	3	2	8	1	0	0	0	0	1	0	0	0	16308	14	1	5	605	5	TNFSF8	9	117692469	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	22407366	117692469	23520962	173	2217										
GARNL3	84253	broad.mit.edu	37	chr9	130119519	130119519	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agatctgtctgtctgactctCccatggtgatgaccttagtg	10	10	4	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:130119519C>A	uc011mae.1	+	21	2358	c.1957C>A	c.(1957-1959)CCC>ACC	p.P653T	GARNL3_uc011mad.1_Missense_Mutation_p.P631T|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	653	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTCTGACTCTCCCATGGTGAT	0.527													1	0	1.33834e-09	0.007413	1.54482e-09	15	28										A	130119519	C	A	130119519	3	1	8	1	0	0	0	0	1	0	0	0	6241	855	30	3	2039	3	GARNL3	9	130119519	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	12427050	130119519	11093912	174	2218										
KIAA0649	9858	broad.mit.edu	37	chr9	138379116	138379116	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagggcacagctggtctgttCagccagggcgggaaggggct	18	10	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr9:138379116C>T	uc004cfr.1	+	4	3309	c.2760C>T	c.(2758-2760)TTC>TTT	p.F920F		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	920						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		CTGGTCTGTTCAGCCAGGGCG	0.701													0	0	0	0.004656	0	27	68										T	138379116	C	T	138379116	2	4	8	1	0	0	0	0	0	0	0	1	8187	825	29	1		1	KIAA0649	9	138379116	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	8259597	138379116	2834315	175	2219										
ITIH5	80760	broad.mit.edu	37	chr10	7608067	7608068	+	Missense_Mutation	DNP	GG	GG	TT													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccaggtggtgtcgctggaagGgcgccggctttttgtagagg							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:7608067_7608068GG>TT	uc001ijq.2	-	13	2531_2532	c.2452_2453CC>AA	c.(2452-2454)CCC>AAC	p.P818N	ITIH5_uc001ijp.2_Missense_Mutation_p.P604N	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	818					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TCGCTGGAAGGGCGCCGGCTTT	0.599													0	0	0	0.004672	0	31	65										TT	7608068	GG	TT	7608067	3	4	8	1	0	0	0	0	1	0	0	0	7907	1232	43	4	425	4	ITIH5	10	7608067	Missense_Mutation	DNP	GG	TCGA-BT-A20N-01A-11D-A14W-08		7608067	127926680	176	2220										
ARHGAP21	57584	broad.mit.edu	37	chr10	24908838	24908838	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtccttacccatgtctgctgAttcaacagactgttctgatg	8	11	3	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:24908838A>C	uc001isb.2	-	9	2473	c.1986T>G	c.(1984-1986)AAT>AAG	p.N662K	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.N662K|ARHGAP21_uc010qdc.1_Missense_Mutation_p.N497K|ARHGAP21_uc001isc.1_Missense_Mutation_p.N652K	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	661					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						ATGTCTGCTGATTCAACAGAC	0.478													0	0	0	0.004672	0	3	92										C	24908838	A	C	24908838	3	2	8	1	0	0	0	0	1	0	0	0	871	330	12	5	3962	5	ARHGAP21	10	24908838	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	17300771	24908838	110625909	177	2221										
MYO3A	53904	broad.mit.edu	37	chr10	26455034	26455034	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	caagtcgagcgaggagccccGcatgagccctgacacctgtg	13	14	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:26455034G>A	uc001isn.2	+	27	3398	c.3038G>A	c.(3037-3039)CGC>CAC	p.R1013H	MYO3A_uc009xko.1_Missense_Mutation_p.R1013H|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1013	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAGGAGCCCCGCATGAGCCCT	0.448													0	0	0	0.013537	0	12	295										A	26455034	G	A	26455034	3	1	8	1	0	0	0	0	1	0	0	0	10076	1087	38	2	3136	2	MYO3A	10	26455034	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1546196	26455034	109079713	178	2222										
WAC	51322	broad.mit.edu	37	chr10	28824669	28824669	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaatgtgcatactcacagagTtagagagagggatggtggtg	15	4	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:28824669T>C	uc001iuf.2	+	3	342	c.257T>C	c.(256-258)GTT>GCT	p.V86A	WAC_uc001iud.2_Missense_Mutation_p.V41A|WAC_uc001iue.2_Splice_Site_p.R40_splice|WAC_uc009xlb.2_Missense_Mutation_p.V41A|WAC_uc001iug.2_Missense_Mutation_p.V86A|WAC_uc001iuh.2_Missense_Mutation_p.V41A	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	86					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						ACTCACAGAGTTAGAGAGAGG	0.393													0	0	0	0.003954	0	22	42										C	28824669	T	C	28824669	3	2	8	1	0	0	0	0	1	0	0	0	17244	1725	60	5	267	5	WAC	10	28824669	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	2369635	28824669	106710078	179	2223										
DLG5	9231	broad.mit.edu	37	chr10	79576344	79576344	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tccccgagggacgcggggttGacagcgattctgggcaatgt	16	10	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:79576344G>T	uc001jzk.2	-	20	4060	c.3990C>A	c.(3988-3990)GTC>GTA	p.V1330V	DLG5_uc001jzi.2_Silent_p.V85V|DLG5_uc001jzj.2_Silent_p.V745V|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Silent_p.V934V	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1330					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACGCGGGGTTGACAGCGATTC	0.617													1	0	0.000602214	0.000602	0.000628668	5	71										T	79576344	G	T	79576344	2	4	8	1	0	0	0	0	0	0	0	1	4558	1277	45	3		3	DLG5	10	79576344	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	50751675	79576344	55958403	180	2224										
MAT1A	4143	broad.mit.edu	37	chr10	82043718	82043718	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgcttgatggtgtccctcacCacccgctggtagtccaccat	9	15	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:82043718C>T	uc001kbw.2	-	3	501	c.246G>A	c.(244-246)GTG>GTA	p.V82V		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	82					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGTCCCTCACCACCCGCTGGT	0.592													0	0	0	0.001984	0	7	29										T	82043718	C	T	82043718	2	4	8	1	0	0	0	0	0	0	0	1	9329	581	21	2		2	MAT1A	10	82043718	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2467374	82043718	53491029	181	2225										
CRTAC1	55118	broad.mit.edu	37	chr10	99696115	99696115	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acttcagaaccaggttgggtCcattgtacctggaggaggaa	13	8	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:99696115C>G	uc001kou.1	-	3	589	c.233G>C	c.(232-234)GGA>GCA	p.G78A	CRTAC1_uc001kov.2_Missense_Mutation_p.G67A|CRTAC1_uc001kot.1_5'UTR	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	78	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CAGGTTGGGTCCATTGTACCT	0.657													0	0	0	0.001984	0	6	19										G	99696115	C	G	99696115	3	3	8	1	0	0	0	0	1	0	0	0	3896	855	30	1	1804	1	CRTAC1	10	99696115	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	17652397	99696115	35838632	182	2226										
ADAM12	8038	broad.mit.edu	37	chr10	127737960	127737960	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtttctatggaaacggcattGgtaccaatgactggccggct	12	9	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:127737960G>C	uc001ljk.2	-	16	2201	c.1788C>G	c.(1786-1788)ACC>ACG	p.T596T	ADAM12_uc010qul.1_Silent_p.T547T|ADAM12_uc001ljm.2_Silent_p.T596T|ADAM12_uc001ljn.2_Silent_p.T593T|ADAM12_uc001ljl.3_Silent_p.T593T	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	596	Extracellular (Potential).|Cys-rich.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		AAACGGCATTGGTACCAATGA	0.532													0	0	0	0.00245	0	14	82										C	127737960	G	C	127737960	2	2	8	1	0	0	0	0	0	0	0	1	236	1335	47	4		4	ADAM12	10	127737960	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	28041845	127737960	7796787	183	2227										
ADAM12	8038	broad.mit.edu	37	chr10	128018989	128018989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agaggaactcaccttggagtCgaagctcttcactgggatcc	11	11	3	1	rs150357794		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr10:128018989C>T	uc001ljk.2	-	2	591	c.178G>A	c.(178-180)GAC>AAC	p.D60N	ADAM12_uc010qul.1_Missense_Mutation_p.D60N|ADAM12_uc001ljm.2_Missense_Mutation_p.D60N|ADAM12_uc001ljn.2_Missense_Mutation_p.D60N|ADAM12_uc001ljl.3_Missense_Mutation_p.D60N	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	60					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		ACCTTGGAGTCGAAGCTCTTC	0.473													0	0	0	0.00308	0	6	89										T	128018989	C	T	128018989	3	4	8	1	0	0	0	0	1	0	0	0	236	884	31	1	2747	1	ADAM12	10	128018989	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	281029	128018989	7515758	184	2228										
SIGIRR	59307	broad.mit.edu	37	chr11	408113	408113	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaggagaagctgatgttctgGatggagcaggtgaaggcccc	17	7	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:408113G>C	uc001lpd.2	-	4	630	c.300C>G	c.(298-300)ATC>ATG	p.I100M	SIGIRR_uc001lpf.2_Missense_Mutation_p.I100M|SIGIRR_uc001lpe.1_Missense_Mutation_p.I100M|SIGIRR_uc001lpg.2_Missense_Mutation_p.I100M	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	100	Ig-like C2-type.|Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGATGTTCTGGATGGAGCAGG	0.587													0	0	0	0.004656	0	24	42										C	408113	G	C	408113	3	2	8	1	0	0	0	0	1	0	0	0	14304	1164	41	1	960	1	SIGIRR	11	408113	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		408113	134598403	185	2229										
OR56A4	120793	broad.mit.edu	37	chr11	6023399	6023399	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggatgttgagcaggatggggAcatctggaggaattctcttc	15	6	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:6023399A>C	uc010qzv.1	-	1	980	c.980T>G	c.(979-981)GTC>GGC	p.V327G		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGATGGGGACATCTGGAGG	0.517													0	0	0	0.000602	0	5	14										C	6023399	A	C	6023399	3	2	8	1	0	0	0	0	1	0	0	0	11135	275	10	5	119	5	OR56A4	11	6023399	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	5615286	6023399	128983117	186	2230										
OR56B4	196335	broad.mit.edu	37	chr11	6129720	6129720	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgctgaggctgaactcagcaGaagcaatgtccaaggctctg	12	10	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:6129720G>T	uc010qzx.1	+	1	712	c.712G>T	c.(712-714)GAA>TAA	p.E238*		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAACTCAGCAGAAGCAATGTC	0.493													1	0	1.28384e-07	0.012319	1.44075e-07	23	24										T	6129720	G	T	6129720	4	4	8	1	0	0	0	0	0	1	0	0	11138	943	33	3	714	3	OR56B4	11	6129720	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	106321	6129720	128876796	187	2231										
FAM160A2	84067	broad.mit.edu	37	chr11	6244846	6244846	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagggggtgctaaccgggcaGaagtaagagtgatccgcgat	16	8	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:6244846G>A	uc001mcl.3	-	3	1130	c.771C>T	c.(769-771)TTC>TTT	p.F257F	FAM160A2_uc001mck.3_Silent_p.F257F|FAM160A2_uc001mcm.2_Silent_p.F257F	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	257					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						TAACCGGGCAGAAGTAAGAGT	0.597													0	0	0	0.007413	0	18	86										A	6244846	G	A	6244846	2	1	8	1	0	0	0	0	0	0	0	1	5469	933	33	1		1	FAM160A2	11	6244846	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	115126	6244846	128761670	188	2232										
DCHS1	8642	broad.mit.edu	37	chr11	6649910	6649910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tctggatcagaggcccgaagCatggtaagggtctgggggtc	17	8	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:6649910C>T	uc001mem.1	-	13	5723	c.5313G>A	c.(5311-5313)ATG>ATA	p.M1771I		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1771	Cadherin 17.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGCCCGAAGCATGGTAAGGG	0.577													0	0	0	0.003163	0	13	20										T	6649910	C	T	6649910	3	4	8	1	0	0	0	0	1	0	0	0	4287	710	25	2	4619	2	DCHS1	11	6649910	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	405064	6649910	128356606	189	2233										
NAV2	89797	broad.mit.edu	37	chr11	19970352	19970352	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gactgggccagtccagccctCggctccaagcaggagacgcc	13	16	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:19970352C>T	uc010rdm.1	+	11	2801	c.2440C>T	c.(2440-2442)CGG>TGG	p.R814W	NAV2_uc001mpp.2_Missense_Mutation_p.R727W|NAV2_uc001mpr.3_Missense_Mutation_p.R791W	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	814						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GTCCAGCCCTCGGCTCCAAGC	0.592													0	0	0	0.009096	0	4	17										T	19970352	C	T	19970352	3	4	8	1	0	0	0	0	1	0	0	0	10184	875	31	1	2488	1	NAV2	11	19970352	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	13320442	19970352	115036164	190	2234										
CD5	921	broad.mit.edu	37	chr11	60885820	60885820	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggctgaactgtggggtgcccTtaagccttggccccttcctt	12	13	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:60885820T>C	uc009ynk.2	+	3	371	c.268T>C	c.(268-270)TTA>CTA	p.L90L		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	90	Extracellular (Potential).|SRCR 1.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		TGGGGTGCCCTTAAGCCTTGG	0.582													0	0	0	0.000602	0	5	175										C	60885820	T	C	60885820	2	2	8	1	0	0	0	0	0	0	0	1	3021	1606	56	5		5	CD5	11	60885820	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	40915468	60885820	74120696	191	2235										
AHNAK	79026	broad.mit.edu	37	chr11	62285078	62285078	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atgtgtccaagttgagagcaGaggagacttggggtcccttc	14	8	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:62285078G>C	uc001ntl.2	-	5	17111	c.16811C>G	c.(16810-16812)TCT>TGT	p.S5604C	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5604	Gly-rich.				nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GTTGAGAGCAGAGGAGACTTG	0.537													0	0	0	0.01441	0	54	132										C	62285078	G	C	62285078	3	2	8	1	0	0	0	0	1	0	0	0	414	942	33	1	981	1	AHNAK	11	62285078	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1399258	62285078	72721438	192	2236										
SAPS3	55291	broad.mit.edu	37	chr11	68370851	68370851	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aagccagctctgacggagagGaggatgcagaaagtacagac	14	8	1	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:68370851G>T	uc001onw.2	+	22	2608	c.2341G>T	c.(2341-2343)GAG>TAG	p.E781*	SAPS3_uc001onv.2_Nonsense_Mutation_p.E781*|SAPS3_uc001ony.3_Nonsense_Mutation_p.E752*|SAPS3_uc001onx.2_Nonsense_Mutation_p.E775*|SAPS3_uc009ysh.2_Nonsense_Mutation_p.E701*|SAPS3_uc001onu.2_Nonsense_Mutation_p.E701*|SAPS3_uc010rqc.1_Nonsense_Mutation_p.E549*|SAPS3_uc010rqd.1_Nonsense_Mutation_p.E464*|SAPS3_uc001onz.2_Nonsense_Mutation_p.E109*|SAPS3_uc001ooa.2_Nonsense_Mutation_p.E231*	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	781					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			TGACGGAGAGGAGGATGCAGA	0.542													1	0	3.7963e-18	0.00333	4.63356e-18	24	35										T	68370851	G	T	68370851	4	4	8	1	0	0	0	0	0	1	0	0	13838	1175	41	3	2419	3	SAPS3	11	68370851	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6085773	68370851	66635665	193	2237										
PAAF1	80227	broad.mit.edu	37	chr11	73620513	73620513	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttctcgagatgggacagcacGactttgggattgtgggcgct	15	8	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:73620513G>A	uc001ouk.1	+	7	636	c.602G>A	c.(601-603)CGA>CAA	p.R201Q	PAAF1_uc001oul.1_Missense_Mutation_p.R184Q|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.R184Q	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	201	WD 3.				interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					GGGACAGCACGACTTTGGGAT	0.517													0	0	0	0.010729	0	10	65										A	73620513	G	A	73620513	3	1	8	1	0	0	0	0	1	0	0	0	11362	1058	37	1	628	1	PAAF1	11	73620513	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	5249662	73620513	61386003	194	2238										
AMOTL1	154810	broad.mit.edu	37	chr11	94602363	94602363	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aatctgttctctgccctcagGattgctgctggggaaggagc	13	10	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:94602363G>T	uc001pfb.2	+	12	2659	c.2489G>T	c.(2488-2490)GGA>GTA	p.G830V	AMOTL1_uc001pfc.2_Missense_Mutation_p.G780V	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	830						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CTGCCCTCAGGATTGCTGCTG	0.483													1	0	1.024e-07	0.000602	1.15881e-07	3	19										T	94602363	G	T	94602363	3	4	8	1	0	0	0	0	1	0	0	0	583	1188	41	3	2535	3	AMOTL1	11	94602363	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	20981850	94602363	40404153	195	2239										
KIAA1826	84437	broad.mit.edu	37	chr11	105880645	105880645	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctttcggcctcgatatccaGtcgtcgtttttccaactcta	6	14	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:105880645G>C	uc001piy.2	-	3	828	c.655C>G	c.(655-657)CTG>GTG	p.L219V	KIAA1826_uc001piz.2_Missense_Mutation_p.L219V	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	219	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		TCGATATCCAGTCGTCGTTTT	0.443													0	0	0	0.009096	0	4	101										C	105880645	G	C	105880645	3	2	8	1	0	0	0	0	1	0	0	0	8260	1020	36	4	386	4	KIAA1826	11	105880645	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	11278282	105880645	29125871	196	2240										
HSPB2	3316	broad.mit.edu	37	chr11	111784284	111784284	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccgagcttaggctcagtgagGgcaagttccaggcatttctg	13	10	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:111784284G>T	uc001pmg.2	+	2	308	c.214G>T	c.(214-216)GGC>TGC	p.G72C	CRYAB_uc001pmf.1_5'Flank|CRYAB_uc010rwp.1_5'Flank|HSPB2_uc009yyj.2_RNA|C11orf52_uc001pmh.2_Intron	NM_001541	NP_001532	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	72					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			ovary(2)|skin(1)	3		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		GCTCAGTGAGGGCAAGTTCCA	0.637													1	0	3.27435e-08	0.00245	3.71584e-08	15	76										T	111784284	G	T	111784284	3	4	8	1	0	0	0	0	1	0	0	0	7420	1232	43	4	220	4	HSPB2	11	111784284	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	5903639	111784284	23222232	197	2241										
FAM55D	54827	broad.mit.edu	37	chr11	114441787	114441787	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tactcacactgagatcctggAaaatgtcctttatgatgaga	8	8	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:114441787A>G	uc001ppc.2	-	6	1689	c.1508T>C	c.(1507-1509)TTC>TCC	p.F503S	FAM55D_uc001ppd.2_Missense_Mutation_p.F219S	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	503						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		GAGATCCTGGAAAATGTCCTT	0.363													0	0	0	0.004672	0	3	64										G	114441787	A	G	114441787	3	3	8	1	0	0	0	0	1	0	0	0	5587	246	9	5	130	5	FAM55D	11	114441787	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	2657503	114441787	20564729	198	2242										
TAGLN	6876	broad.mit.edu	37	chr11	117073833	117073833	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gcggctggtggagtggatcaTagtgcagtgtggccctgatg	18	7	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:117073833T>C	uc001pqm.2	+	2	225	c.104T>C	c.(103-105)ATA>ACA	p.I35T	uc001pqk.1_5'Flank|TAGLN_uc001pql.1_Intron|TAGLN_uc001pqn.2_Missense_Mutation_p.I35T|TAGLN_uc001pqo.2_Missense_Mutation_p.I35T|TAGLN_uc001pqp.2_Missense_Mutation_p.I35T|uc001pqq.1_5'Flank	NM_003186	NP_003177	Q01995	TAGL_HUMAN	transgelin	35	CH.				muscle organ development	cytoplasm	actin binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|Epithelial(105;5.49e-05)|all cancers(92;0.000435)		GAGTGGATCATAGTGCAGTGT	0.612													0	0	0	0.00245	0	13	10										C	117073833	T	C	117073833	3	2	8	1	0	0	0	0	1	0	0	0	15535	1406	49	5	106	5	TAGLN	11	117073833	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	2632046	117073833	17932683	199	2243										
MLL	4297	broad.mit.edu	37	chr11	118374909	118374909	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctgaagatgctggggagaaaGaacatgtcactaagagttct	12	6	2	5			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:118374909G>C	uc001pta.2	+	27	8316	c.8293G>C	c.(8293-8295)GAA>CAA	p.E2765Q	MLL_uc001ptb.2_Missense_Mutation_p.E2768Q	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2765					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGGGGAGAAAGAACATGTCAC	0.403			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.001168	0	5	64										C	118374909	G	C	118374909	3	2	8	1	0	0	0	0	1	0	0	0	9620	943	33	1	8399	1	MLL	11	118374909	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1301076	118374909	16631607	200	2244										
HINFP	25988	broad.mit.edu	37	chr11	119003661	119003661	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gattttgagaactgcaccttCagtgcccgatccctctgctc	8	14	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:119003661C>T	uc001pvp.2	+	9	1152	c.963C>T	c.(961-963)TTC>TTT	p.F321F	HINFP_uc001pvq.2_Silent_p.F321F|HINFP_uc001pvr.2_Silent_p.F74F	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	321	C2H2-type 8.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ACTGCACCTTCAGTGCCCGAT	0.522													0	0	0	0.01441	0	57	38										T	119003661	C	T	119003661	2	4	8	1	0	0	0	0	0	0	0	1	7110	825	29	1		1	HINFP	11	119003661	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	628752	119003661	16002855	201	2245										
OR8B12	219858	broad.mit.edu	37	chr11	124413346	124413346	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggtagtggagaaacagaaatCtattaaagagaggttaaaaa	11	2	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:124413346C>G	uc010sam.1	-	1	205	c.205G>C	c.(205-207)GAT>CAT	p.D69H		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		AAACAGAAATCTATTAAAGAG	0.453													0	0	0	0.008871	0	20	15										G	124413346	C	G	124413346	3	3	8	1	0	0	0	0	1	0	0	0	11226	913	32	1	729	1	OR8B12	11	124413346	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	5409685	124413346	10593170	202	2246										
PKNOX2	63876	broad.mit.edu	37	chr11	125298937	125298937	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cccacggaggatgagaagagGcagatcgcagcccagaccaa	13	12	0	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:125298937G>T	uc001qbu.2	+	11	1280	c.966G>T	c.(964-966)AGG>AGT	p.R322S	PKNOX2_uc010saz.1_Missense_Mutation_p.R293S|PKNOX2_uc010sba.1_Missense_Mutation_p.R293S|PKNOX2_uc010sbb.1_Missense_Mutation_p.R258S|PKNOX2_uc001qbv.2_Missense_Mutation_p.R87S	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	322	Homeobox.					nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		ATGAGAAGAGGCAGATCGCAG	0.597											OREG0021475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.35478e-16	0.003163	4.02175e-16	14	17										T	125298937	G	T	125298937	3	4	8	1	0	0	0	0	1	0	0	0	11983	1194	42	4	996	4	PKNOX2	11	125298937	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	885591	125298937	9707579	203	2247										
ARHGAP32	9743	broad.mit.edu	37	chr11	128844494	128844494	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgaagaggagagacaggttcAgagcttgctgtgcttcctgg	15	7	1	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:128844494A>C	uc009zcp.2	-	20	2556	c.2556T>G	c.(2554-2556)TCT>TCG	p.S852S	ARHGAP32_uc009zcq.1_Silent_p.S812S|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Silent_p.S503S	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	852					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						AGACAGGTTCAGAGCTTGCTG	0.443													0	0	0	0.01441	0	55	59										C	128844494	A	C	128844494	2	2	8	1	0	0	0	0	0	0	0	1	881	175	7	5		5	ARHGAP32	11	128844494	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	3545557	128844494	6162022	204	2248										
OPCML	4978	broad.mit.edu	37	chr11	132290160	132290160	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccagtgctctggaggccgagTttacaccatcaatgactgct	10	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr11:132290160T>A	uc001qgs.2	-	7	1015	c.965A>T	c.(964-966)AAC>ATC	p.N322I	OPCML_uc001qgu.2_Missense_Mutation_p.N315I|OPCML_uc010sck.1_Missense_Mutation_p.N331I|OPCML_uc001qgt.2_Missense_Mutation_p.N321I|OPCML_uc010scl.1_Missense_Mutation_p.N281I	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	322					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GGAGGCCGAGTTTACACCATC	0.502													0	0	0	0.001984	0	7	46										A	132290160	T	A	132290160	3	1	8	1	0	0	0	0	1	0	0	0	10874	1725	60	5	76	5	OPCML	11	132290160	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	3445666	132290160	2716356	205	2249										
KDM5A	5927	broad.mit.edu	37	chr12	416853	416853	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccgtacgggcaacttctgaaGggataccaggagtgacagaa	13	9	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:416853G>A	uc001qif.1	-	23	4060	c.3697C>T	c.(3697-3699)CTT>TTT	p.L1233F	KDM5A_uc001qie.1_Missense_Mutation_p.L1233F	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1233					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AACTTCTGAAGGGATACCAGG	0.527			T 	NUP98	AML								0	0	0	0.010504	0	20	48										A	416853	G	A	416853	3	1	8	1	0	0	0	0	1	0	0	0	8133	1000	35	2	1399	2	KDM5A	12	416853	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		416853	133435042	206	2250										
WNK1	65125	broad.mit.edu	37	chr12	936296	936296	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtcttcagtttcttcatactCgaactccacctatcattcac	3	14	6	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:936296C>G	uc001qio.3	+	3	1528	c.1021C>G	c.(1021-1023)CGA>GGA	p.R341G	WNK1_uc001qin.2_Missense_Mutation_p.R341G|WNK1_uc001qip.3_Missense_Mutation_p.R341G	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	341	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCTTCATACTCGAACTCCACC	0.438													0	0	0	0.007413	0	18	228										G	936296	C	G	936296	3	3	8	1	0	0	0	0	1	0	0	0	17374	876	31	1	1031	1	WNK1	12	936296	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	519443	936296	132915599	207	2251										
LRTM2	654429	broad.mit.edu	37	chr12	1943830	1943830	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctcaaaaagcgccagcccctGatgggggaccccgagggcga	14	14	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:1943830G>A	uc001qjt.2	+	5	1862	c.1056G>A	c.(1054-1056)CTG>CTA	p.L352L	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Silent_p.L352L|LRTM2_uc010sdx.1_Silent_p.L352L|LRTM2_uc001qjv.2_Silent_p.L114L	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	352	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GCCAGCCCCTGATGGGGGACC	0.652													0	0	0	0.008291	0	8	82										A	1943830	G	A	1943830	2	1	8	1	0	0	0	0	0	0	0	1	9045	1277	45	1		1	LRTM2	12	1943830	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1007534	1943830	131908065	208	2252										
C12orf60	144608	broad.mit.edu	37	chr12	14976352	14976352	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacttctatacagaagacacCaaagagcaatcagatgtcac	7	10	3	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:14976352C>G	uc001rcj.3	+	2	687	c.483C>G	c.(481-483)ACC>ACG	p.T161T		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	161										ovary(1)|central_nervous_system(1)	2						CAGAAGACACCAAAGAGCAAT	0.413													0	0	0	0.004656	0	25	48										G	14976352	C	G	14976352	2	3	8	1	0	0	0	0	0	0	0	1	1703	581	21	4		4	C12orf60	12	14976352	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	13032522	14976352	118875543	209	2253										
FGD4	121512	broad.mit.edu	37	chr12	32760950	32760950	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atgctagaacctgttcagcgGattccccggtatgagatgct	11	10	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:32760950G>T	uc001rkz.2	+	8	1530	c.1053G>T	c.(1051-1053)CGG>CGT	p.R351R	FGD4_uc001rlc.2_Silent_p.R436R|FGD4_uc001rky.2_Silent_p.R103R|FGD4_uc001rla.2_Silent_p.R7R|FGD4_uc010ske.1_Silent_p.R463R|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	351	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					CTGTTCAGCGGATTCCCCGGT	0.378													1	0	4.0181e-32	0.01441	5.02574e-32	49	131										T	32760950	G	T	32760950	2	4	8	1	0	0	0	0	0	0	0	1	5835	1161	41	3		3	FGD4	12	32760950	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	17784598	32760950	101090945	210	2254										
MLL2	8085	broad.mit.edu	37	chr12	49444319	49444319	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acactgaggaggaaggggctCcatcaggatgggagaagccg	17	8	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:49444319C>A	uc001rta.3	-	11	3052	c.3052G>T	c.(3052-3054)GAG>TAG	p.E1018*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1018	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGAAGGGGCTCCATCAGGATG	0.612			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	1.10513e-12	0.014323	1.30548e-12	21	32										A	49444319	C	A	49444319	4	1	8	1	0	0	0	0	0	1	0	0	9621	864	30	3	13737	3	MLL2	12	49444319	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	16683369	49444319	84407576	211	2255										
LMBR1L	55716	broad.mit.edu	37	chr12	49491848	49491848	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tagaaattgcccagccagttGaagcgtccaaagtcacccag	9	12	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:49491848G>A	uc001rth.3	-	16	1623	c.1281C>T	c.(1279-1281)TTC>TTT	p.F427F	LMBR1L_uc001rtg.3_Silent_p.F422F|LMBR1L_uc001rti.3_Silent_p.F407F	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	427	Extracellular (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1						CCAGCCAGTTGAAGCGTCCAA	0.572											OREG0021783	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	106										A	49491848	G	A	49491848	2	1	8	1	0	0	0	0	0	0	0	1	8841	1281	45	1		1	LMBR1L	12	49491848	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	47529	49491848	84360047	212	2256										
DIP2B	57609	broad.mit.edu	37	chr12	51138369	51138369	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaattgtcattgaaatttcaGtgccgtgttcacatggacca	9	8	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:51138369G>T	uc001rwv.2	+	38	4635	c.4479_splice	c.e38-1	p.C1493_splice	DIP2B_uc009zlt.2_Splice_Site_p.C923_splice	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B							nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGAAATTTCAGTGCCGTGTTC	0.468													1	0	5.2432e-18	0.01441	6.38028e-18	42	42										T	51138369	G	T	51138369	5	4	8	1	0	0	0	0	0	0	1	0	4528	1043	36	4	4628	4	DIP2B	12	51138369	Splice_Site	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1646521	51138369	82713526	213	2257										
CSRNP2	81566	broad.mit.edu	37	chr12	51461550	51461550	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cttcccgtgacaggcggatgGctcgaagttcttgcttctct	11	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:51461550G>C	uc001rxu.1	-	4	912	c.614C>G	c.(613-615)GCC>GGC	p.A205G		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	205					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CAGGCGGATGGCTCGAAGTTC	0.572													0	0	0	0.001168	0	5	61										C	51461550	G	C	51461550	3	2	8	1	0	0	0	0	1	0	0	0	3964	1203	42	4	1025	4	CSRNP2	12	51461550	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	323181	51461550	82390345	214	2258										
KRT76	51350	broad.mit.edu	37	chr12	53170846	53170846	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctcccccaaagcctccagccCgggagctgccagctgccacg	10	20	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:53170846C>T	uc001sax.2	-	1	284	c.230G>A	c.(229-231)CGG>CAG	p.R77Q		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	77	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						GCCTCCAGCCCGGGAGCTGCC	0.428													0	0	0	0.00499	0	16	153										T	53170846	C	T	53170846	3	4	8	1	0	0	0	0	1	0	0	0	8489	652	23	2	1722	2	KRT76	12	53170846	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1709296	53170846	80681049	215	2259										
KRT79	338785	broad.mit.edu	37	chr12	53228038	53228038	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtttgccgagagacggaggAcctcatagctgcagaggggc	16	9	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:53228038A>G	uc001sbb.2	-	1	40	c.7T>C	c.(7-9)TCC>CCC	p.S3P		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	3	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						GAGACGGAGGACCTCATAGCT	0.612													0	0	0	0.004482	0	6	28										G	53228038	A	G	53228038	3	3	8	1	0	0	0	0	1	0	0	0	8492	275	10	5	1636	5	KRT79	12	53228038	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	57192	53228038	80623857	216	2260										
MYO1A	4640	broad.mit.edu	37	chr12	57423361	57423361	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccttggtcaggaggagaatcCgagaagaagtctagggacgg	16	7	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:57423361C>T	uc001smw.3	-	26	2978	c.2735G>A	c.(2734-2736)CGG>CAG	p.R912Q	MYO1A_uc010sqz.1_Missense_Mutation_p.R750Q|MYO1A_uc009zpd.2_Missense_Mutation_p.R912Q	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	912					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						GAGGAGAATCCGAGAAGAAGT	0.552													0	0	0	0.001168	0	6	62										T	57423361	C	T	57423361	3	4	8	1	0	0	0	0	1	0	0	0	10068	652	23	2	408	2	MYO1A	12	57423361	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	4195323	57423361	76428534	217	2261										
LRIG3	121227	broad.mit.edu	37	chr12	59274438	59274438	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacacactgatatttcccctCactggcaaattccacctcgc	5	16	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:59274438C>T	uc001sqr.2	-	13	1972	c.1726G>A	c.(1726-1728)GAG>AAG	p.E576K	LRIG3_uc009zqh.2_Missense_Mutation_p.E516K|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	576	Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			TATTTCCCCTCACTGGCAAAT	0.468													0	0	0	0.006214	0	9	35										T	59274438	C	T	59274438	3	4	8	1	0	0	0	0	1	0	0	0	8946	835	29	1	1661	1	LRIG3	12	59274438	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1851077	59274438	74577457	218	2262										
C12orf26	84190	broad.mit.edu	37	chr12	82793112	82793112	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aagtgaatcaaatatatattCacctttaacctcttttatca	2	8	4	1	rs141543492		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:82793112C>T	uc001szq.2	+	4	1091	c.1070C>T	c.(1069-1071)TCA>TTA	p.S357L		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	357											0						AATATATATTCACCTTTAACC	0.318													0	0	0	0.007413	0	20	24										T	82793112	C	T	82793112	3	4	8	1	0	0	0	0	1	0	0	0	1679	838	29	1	1084	1	C12orf26	12	82793112	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	23518674	82793112	51058783	219	2263										
C12orf50	160419	broad.mit.edu	37	chr12	88420329	88420329	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctgtgataaaagatacagctGatcttcacacaaccaagagg	8	9	2	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:88420329G>T	uc001tam.1	-	3	237	c.69C>A	c.(67-69)ATC>ATA	p.I23I	C12orf50_uc001tan.2_Silent_p.I77I	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	23										skin(2)|ovary(1)	3						AGATACAGCTGATCTTCACAC	0.373													1	0	1.12685e-05	0.004482	1.22708e-05	9	46										T	88420329	G	T	88420329	2	4	8	1	0	0	0	0	0	0	0	1	1695	1280	45	3		3	C12orf50	12	88420329	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	5627217	88420329	45431566	220	2264										
CCDC38	120935	broad.mit.edu	37	chr12	96266046	96266046	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	actgtacttttgccgccattCtttctgtttcatcctctcaa	4	13	4	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:96266046C>G	uc001tek.1	-	14	1705	c.1471G>C	c.(1471-1473)GAA>CAA	p.E491Q		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	491										skin(1)	1						TGCCGCCATTCTTTCTGTTTC	0.403													0	0	0	0.00333	0	22	133										G	96266046	C	G	96266046	3	3	8	1	0	0	0	0	1	0	0	0	2810	922	32	1	232	1	CCDC38	12	96266046	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	7845717	96266046	37585849	221	2265										
ACAD10	80724	broad.mit.edu	37	chr12	112174762	112174762	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tatatggctttttcctttttCcgtgtggctgcaatcctaca	7	10	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:112174762C>T	uc001tsq.2	+	12	1868	c.1668C>T	c.(1666-1668)TTC>TTT	p.F556F	ACAD10_uc001tsp.2_Silent_p.F556F|ACAD10_uc009zvx.2_Silent_p.F587F|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	556							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TTTCCTTTTTCCGTGTGGCTG	0.527													0	0	0	0.003755	0	33	32										T	112174762	C	T	112174762	2	4	8	1	0	0	0	0	0	0	0	1	108	854	30	1		1	ACAD10	12	112174762	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	15908716	112174762	21677133	222	2266										
C12orf51	283450	broad.mit.edu	37	chr12	112605677	112605677	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcgacagcgaggaactctGcagctccttacacacctgcc	9	16	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:112605677G>A	uc009zwc.2	-	64	11005	c.10987C>T	c.(10987-10989)CAG>TAG	p.Q3663*		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GAGGAACTCTGCAGCTCCTTA	0.642													0	0	0	0.001855	0	12	51										A	112605677	G	A	112605677	4	1	8	1	0	0	0	0	0	1	0	0	1696	1328	46	2	1027	2	C12orf51	12	112605677	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	430915	112605677	21246218	223	2267										
IQCD	115811	broad.mit.edu	37	chr12	113633634	113633634	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcactttgtgcctccgccTgagctcctccagcgagatct	9	16	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:113633634T>A	uc001tuu.2	-	3	962	c.790A>T	c.(790-792)AGG>TGG	p.R264W		NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)	1						TGCCTCCGCCTGAGCTCCTCC	0.597													0	0	0	0.009096	0	4	93										A	113633634	T	A	113633634	3	1	8	1	0	0	0	0	1	0	0	0	7805	1579	55	5	257	5	IQCD	12	113633634	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	1027957	113633634	20218261	224	2268										
FBXO21	23014	broad.mit.edu	37	chr12	117627036	117627036	+	Missense_Mutation	SNP	T	T	A													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atcaacagatccttacgtgcTctgaaaagaacctctttgag							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:117627036T>A	uc001twk.2	-	2	410	c.371A>T	c.(370-372)GAG>GTG	p.E124V	FBXO21_uc001twj.2_Missense_Mutation_p.E124V|FBXO21_uc009zwq.2_Missense_Mutation_p.E124V	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	124					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CCTTACGTGCTCTGAAAAGAA	0.478													0	0	0	0.001168	0	6	79										A	117627036	T	A	117627036	3	1	8	1	0	0	0	0	1	0	0	0	5733	1551	54	5	1559	5	FBXO21	12	117627036	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	3993402	117627036	16224859	225	2269	14	2								
FBXO21	23014	broad.mit.edu	37	chr12	117627039	117627039	+	Missense_Mutation	SNP	G	G	A													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aacagatccttacgtgctctGaaaagaacctctttgagaac							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:117627039G>A	uc001twk.2	-	2	407	c.368C>T	c.(367-369)TCA>TTA	p.S123L	FBXO21_uc001twj.2_Missense_Mutation_p.S123L|FBXO21_uc009zwq.2_Missense_Mutation_p.S123L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	123					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TACGTGCTCTGAAAAGAACCT	0.483													0	0	0	0.001984	0	7	77										A	117627039	G	A	117627039	3	1	8	1	0	0	0	0	1	0	0	0	5733	1294	45	1	1562	1	FBXO21	12	117627039	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	3	117627039	16224856	226	2270	14	2								
GCN1L1	10985	broad.mit.edu	37	chr12	120568496	120568496	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccggcaactgccctccgcctGtctcgatgtggtgtctcatg	11	15	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:120568496G>C	uc001txo.2	-	56	7638	c.7625C>G	c.(7624-7626)ACA>AGA	p.T2542R		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2542					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCCTCCGCCTGTCTCGATGTG	0.602													0	0	0	0.00499	0	16	36										C	120568496	G	C	120568496	3	2	8	1	0	0	0	0	1	0	0	0	6299	1377	48	4	402	4	GCN1L1	12	120568496	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2941457	120568496	13283399	227	2271										
GCN1L1	10985	broad.mit.edu	37	chr12	120611536	120611536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttaaggctgaaagcttttttGaaccattcagtgagcttctt	8	7	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:120611536G>C	uc001txo.2	-	14	1300	c.1287C>G	c.(1285-1287)TTC>TTG	p.F429L		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	429					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAGCTTTTTTGAACCATTCAG	0.517													0	0	0	0.000602	0	4	39										C	120611536	G	C	120611536	3	2	8	1	0	0	0	0	1	0	0	0	6299	1281	45	1	6908	1	GCN1L1	12	120611536	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	43040	120611536	13240359	228	2272										
COQ5	84274	broad.mit.edu	37	chr12	120942706	120942706	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aacaatgccaacctggatatGaggggattgttcacttggct	11	8	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:120942706G>C	uc001tyn.2	-	5	782	c.762C>G	c.(760-762)CTC>CTG	p.L254L	COQ5_uc001tyo.2_Silent_p.L173L|COQ5_uc010szj.1_Silent_p.L180L	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	254					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCTGGATATGAGGGGATTGT	0.458													0	0	0	0.004482	0	8	35										C	120942706	G	C	120942706	2	2	8	1	0	0	0	0	0	0	0	1	3748	1277	45	1		1	COQ5	12	120942706	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	331170	120942706	12909189	229	2273										
FZD10	11211	broad.mit.edu	37	chr12	130648250	130648250	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccttcctcatcgacccggccCgcttccgctaccccgagcgc	8	22	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:130648250C>G	uc001uii.2	+	1	1219	c.763C>G	c.(763-765)CGC>GGC	p.R255G	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	255	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CGACCCGGCCCGCTTCCGCTA	0.647													0	0	0	0.010771	0	41	58										G	130648250	C	G	130648250	3	3	8	1	0	0	0	0	1	0	0	0	6129	652	23	4	765	4	FZD10	12	130648250	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	9705544	130648250	3203645	230	2274										
ZNF10	7556	broad.mit.edu	37	chr12	133732756	133732756	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttcagccggagttctcacctCattggacatcaaaagaccca	7	13	4	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr12:133732756C>T	uc009zzb.2	+	5	1371	c.924C>T	c.(922-924)CTC>CTT	p.L308L	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Silent_p.L308L	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	308	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GTTCTCACCTCATTGGACATC	0.428													0	0	0	0.004878	0	38	60										T	133732756	C	T	133732756	2	4	8	1	0	0	0	0	0	0	0	1	17709	813	29	1		1	ZNF10	12	133732756	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3084506	133732756	119139	231	2275										
SACS	26278	broad.mit.edu	37	chr13	23930096	23930096	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atgtgggccaaaaagtgtttGatgaggatctagcatcccga	12	7	1	2	rs146784878		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr13:23930096G>A	uc001uon.2	-	8	1244	c.655C>T	c.(655-657)CAA>TAA	p.Q219*	SACS_uc001uoo.2_Nonsense_Mutation_p.Q72*|SACS_uc001uop.1_Nonsense_Mutation_p.Q6*|SACS_uc001uoq.1_Nonsense_Mutation_p.Q72*	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	219					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAAAGTGTTTGATGAGGATCT	0.378													0	0	0	0.008291	0	11	11										A	23930096	G	A	23930096	4	1	8	1	0	0	0	0	0	1	0	0	13804	1299	45	1	13096	1	SACS	13	23930096	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		23930096	91239782	232	2276										
KIAA0564	23078	broad.mit.edu	37	chr13	42259229	42259229	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acttctcctgggggtaaaatCctcactacctgattcgtatc	7	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr13:42259229C>A	uc001uyj.2	-	35	4351	c.4281G>T	c.(4279-4281)AGG>AGT	p.R1427S		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1427						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GGGGTAAAATCCTCACTACCT	0.398													1	0	1.22384e-17	0.013726	1.48477e-17	34	32										A	42259229	C	A	42259229	3	1	8	1	0	0	0	0	1	0	0	0	8185	854	30	3	1480	3	KIAA0564	13	42259229	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	18329133	42259229	72910649	233	2277										
FOXG1	2290	broad.mit.edu	37	chr14	29237689	29237689	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctgctctgggacctactccCtcaacccctgctccgtcaac	6	20	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:29237689C>T	uc001wqe.2	+	1	1403	c.1204C>T	c.(1204-1206)CTC>TTC	p.L402F		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	402	Interaction with KDM5B.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GACCTACTCCCTCAACCCCTG	0.672													0	0	0	0.004672	0	3	19										T	29237689	C	T	29237689	3	4	8	1	0	0	0	0	1	0	0	0	6007	681	24	2	1206	2	FOXG1	14	29237689	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		29237689	78111851	234	2278										
PRKD1	5587	broad.mit.edu	37	chr14	30066873	30066873	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agcccttgttccttaggaccTcaggagccaggtaagcgggg	14	11	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:30066873T>C	uc001wqh.2	-	16	2439	c.2258A>G	c.(2257-2259)GAG>GGG	p.E753G		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	753	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CCTTAGGACCTCAGGAGCCAG	0.488													0	0	0	0.012319	0	20	63										C	30066873	T	C	30066873	3	2	8	1	0	0	0	0	1	0	0	0	12518	1551	54	5	492	5	PRKD1	14	30066873	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	829184	30066873	77282667	235	2279										
NPAS3	64067	broad.mit.edu	37	chr14	34269591	34269591	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagctctgagcacttcccgtCcccgcagggcggcggcggtg	15	16	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:34269591C>G	uc001wru.2	+	12	2142	c.2078C>G	c.(2077-2079)TCC>TGC	p.S693C	NPAS3_uc001wrs.2_Missense_Mutation_p.S680C|NPAS3_uc001wrt.2_Missense_Mutation_p.S661C|NPAS3_uc001wrv.2_Missense_Mutation_p.S663C	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	693					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CACTTCCCGTCCCCGCAGGGC	0.582													0	0	0	0.013537	0	12	26										G	34269591	C	G	34269591	3	3	8	1	0	0	0	0	1	0	0	0	10564	855	30	1	2179	1	NPAS3	14	34269591	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	4202718	34269591	73079949	236	2280										
NIN	51199	broad.mit.edu	37	chr14	51204963	51204963	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtacctgatgggtttagatgTttttggtgcttgggaagaag	15	3	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:51204963T>A	uc001wym.2	-	27	5861	c.5670A>T	c.(5668-5670)AAA>AAT	p.K1890N	NIN_uc001wyi.2_Missense_Mutation_p.K1890N|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.K1177N|NIN_uc010tqp.1_Missense_Mutation_p.K1896N|NIN_uc001wyo.2_Missense_Mutation_p.K1890N|NIN_uc001wyn.2_RNA	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1890					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GGTTTAGATGTTTTTGGTGCT	0.403			T	PDGFRB	MPD								0	0	0	0.004289	0	37	84										A	51204963	T	A	51204963	3	1	8	1	0	0	0	0	1	0	0	0	10417	1722	60	5	899	5	NIN	14	51204963	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	16935372	51204963	56144577	237	2281										
FRMD6	122786	broad.mit.edu	37	chr14	52167842	52167842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtccaaaagaatggaagaaaGaggccagcaaggtacgacaa	12	7	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:52167842G>A	uc001wzd.2	+	4	544	c.259G>A	c.(259-261)GAG>AAG	p.E87K	FRMD6_uc001wzb.2_Missense_Mutation_p.E87K|FRMD6_uc001wzc.2_Missense_Mutation_p.E87K|FRMD6_uc001wze.2_Missense_Mutation_p.E18K	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	87	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					ATGGAAGAAAGAGGCCAGCAA	0.294													0	0	0	0.009096	0	3	10										A	52167842	G	A	52167842	3	1	8	1	0	0	0	0	1	0	0	0	6054	943	33	1	269	1	FRMD6	14	52167842	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	962879	52167842	55181698	238	2282										
PCNX	22990	broad.mit.edu	37	chr14	71540497	71540497	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttgatcttcggaaagtactCaccacttactatgtcaaggt	7	9	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:71540497C>G	uc001xmo.2	+	27	5534	c.5088C>G	c.(5086-5088)CTC>CTG	p.L1696L	PCNX_uc010are.1_Silent_p.L1585L|PCNX_uc010arf.1_Silent_p.L484L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1696						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGAAAGTACTCACCACTTACT	0.363													0	0	0	0.012213	0	28	84										G	71540497	C	G	71540497	2	3	8	1	0	0	0	0	0	0	0	1	11591	813	29	1		1	PCNX	14	71540497	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	19372655	71540497	35809043	239	2283										
SNW1	22938	broad.mit.edu	37	chr14	78184840	78184840	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atcataaacattataaatttCatcttctccacctgcaaatc	1	11	4	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:78184840C>T	uc001xuf.2	-	13	1309	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	SNW1_uc010tvm.1_Missense_Mutation_p.E353K|SNW1_uc010asu.2_Missense_Mutation_p.E266K|SNW1_uc010tvn.1_Missense_Mutation_p.E428K	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein	428					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		TTATAAATTTCATCTTCTCCA	0.363													0	0	0	0.00308	0	7	64										T	78184840	C	T	78184840	3	4	8	1	0	0	0	0	1	0	0	0	14879	835	29	1	336	1	SNW1	14	78184840	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6644343	78184840	29164700	240	2284										
SEL1L	6400	broad.mit.edu	37	chr14	81946033	81946033	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaagactggaacttgtgcatCtgggctggcttcagctgcca	13	10	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:81946033C>A	uc010tvv.1	-	20	2215	c.2098G>T	c.(2098-2100)GAT>TAT	p.D700Y		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	700	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		ACTTGTGCATCTGGGCTGGCT	0.418													1	0	2.0095e-06	0.001984	2.21813e-06	6	60										A	81946033	C	A	81946033	3	1	8	1	0	0	0	0	1	0	0	0	14010	913	32	3	294	3	SEL1L	14	81946033	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3761193	81946033	25403507	241	2285										
GALC	2581	broad.mit.edu	37	chr14	88401080	88401080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gatgccctgttaagtattagCgtgtggcttccacaagaaag	11	8	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:88401080C>T	uc001xvt.2	-	17	2453	c.2054G>A	c.(2053-2055)CGC>CAC	p.R685H	GALC_uc010tvw.1_Intron|GALC_uc010tvx.1_Missense_Mutation_p.R659H|GALC_uc010tvy.1_Missense_Mutation_p.R662H|GALC_uc010tvz.1_Intron	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	685					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TAAGTATTAGCGTGTGGCTTC	0.403													0	0	0	0.001984	0	6	78										T	88401080	C	T	88401080	3	4	8	1	0	0	0	0	1	0	0	0	6201	768	27	2	7	2	GALC	14	88401080	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6455047	88401080	18948460	242	2286										
KIAA1409	57578	broad.mit.edu	37	chr14	93944052	93944052	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atcattgaatatcttagcacAtcttttctaccaatggctat	4	9	4	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:93944052A>G	uc001ybv.1	+	1	149	c.66A>G	c.(64-66)ACA>ACG	p.T22T	KIAA1409_uc001ybs.1_Silent_p.T22T|KIAA1409_uc001ybu.1_Silent_p.T22T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	199						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATCTTAGCACATCTTTTCTAC	0.343													0	0	0	0.01441	0	47	99										G	93944052	A	G	93944052	2	3	8	1	0	0	0	0	0	0	0	1	8230	204	8	5		5	KIAA1409	14	93944052	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	5542972	93944052	13405488	243	2287										
FAM181A	90050	broad.mit.edu	37	chr14	94391663	94391664	+	Frame_Shift_Ins	INS	-	-	A													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tggagagaggaatgatgcagINScccccacaaatcacagaagg							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:94391663_94391664insA	uc001ybz.1	+	2	353_354	c.46_47insA	c.(46-48)GCCfs	p.A16fs	C14orf86_uc001yby.2_Intron|FAM181A_uc010aus.1_5'Flank|FAM181A_uc001yca.1_5'Flank	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	16											0						GAATGATGCAGCCCCCACAAAT	0.53																		12	35	---	---								A	94391664	-	A	94391663	7	5	8	1	0	1	1	0	0	0	0	0	5508	971	34	0	48	0	FAM181A	14	94391663	Frame_Shift_Ins	INS	-	TCGA-BT-A20N-01A-11D-A14W-08	447611	94391663	12957877	244	2288										
EML1	2009	broad.mit.edu	37	chr14	100375681	100375681	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gagtccctgtttttcctataGtgctctaatgaagctgtgtt	9	8	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:100375681G>C	uc001ygs.2	+	11	1174	c.1105_splice	c.e11-1	p.C369_splice	EML1_uc010avt.1_Splice_Site_p.C356_splice|EML1_uc010tww.1_Splice_Site_p.C357_splice|EML1_uc001ygq.2_Splice_Site_p.C388_splice|EML1_uc001ygr.2_Splice_Site_p.C388_splice	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1							cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TTTTCCTATAGTGCTCTAATG	0.408													0	0	0	0.006214	0	9	124										C	100375681	G	C	100375681	5	2	8	1	0	0	0	0	0	0	1	0	5096	1043	36	4	1207	4	EML1	14	100375681	Splice_Site	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	5984018	100375681	6973859	245	2289										
C14orf68	283600	broad.mit.edu	37	chr14	100792529	100792529	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gagccaaagtacacaggcatCtggcactgcgtccgggatac	12	12	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:100792529C>A	uc001yhc.2	+	3	181	c.108C>A	c.(106-108)ATC>ATA	p.I36I	C14orf68_uc001yhd.2_Translation_Start_Site	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	36	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				ACACAGGCATCTGGCACTGCG	0.667													1	0	2.80697e-09	0.010729	3.23082e-09	9	10										A	100792529	C	A	100792529	2	1	8	1	0	0	0	0	0	0	0	1	1778	903	32	3		3	C14orf68	14	100792529	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	416848	100792529	6557011	246	2290										
TECPR2	9895	broad.mit.edu	37	chr14	102904406	102904406	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ggtcccggctatggcatcctCagcttggtggtctccgagaa	13	12	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr14:102904406C>A	uc001ylw.1	+	10	2590	c.2442C>A	c.(2440-2442)CTC>CTA	p.L814L	TECPR2_uc010awl.2_Silent_p.L814L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	814							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						ATGGCATCCTCAGCTTGGTGG	0.587											OREG0022547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.17888e-05	0.006214	2.35365e-05	9	143										A	102904406	C	A	102904406	2	1	8	1	0	0	0	0	0	0	0	1	15741	813	29	3		3	TECPR2	14	102904406	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2111877	102904406	4445134	247	2291										
MGA	23269	broad.mit.edu	37	chr15	42041126	42041126	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtcatgtttcggaacccagGtataaagttcttttttatga	8	6	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:42041126G>T	uc010ucy.1	+	16	5684	c.5503_splice	c.e16+1	p.G1835_splice	MGA_uc010ucz.1_Splice_Site_p.G1626_splice|MGA_uc010uda.1_Splice_Site_p.G451_splice|MGA_uc001zoi.2_Splice_Site_p.G49_splice	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1							MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CGGAACCCAGGTATAAAGTTC	0.403													1	0	1.836e-18	0.003755	2.24771e-18	36	21										T	42041126	G	T	42041126	5	4	8	1	0	0	0	0	0	0	1	0	9540	1275	44	4	5562	4	MGA	15	42041126	Splice_Site	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		42041126	60490266	248	2292										
DMXL2	23312	broad.mit.edu	37	chr15	51773566	51773566	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgcagataaggcagatgtttTggttacttttggaattttgg	12	3	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:51773566T>C	uc002abf.2	-	24	5962	c.5737A>G	c.(5737-5739)AAA>GAA	p.K1913E	DMXL2_uc002abd.2_5'UTR|DMXL2_uc010ufy.1_Missense_Mutation_p.K1913E|DMXL2_uc010bfa.2_Missense_Mutation_p.K1277E	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1913						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GCAGATGTTTTGGTTACTTTT	0.383													0	0	0	0.01441	0	98	69										C	51773566	T	C	51773566	3	2	8	1	0	0	0	0	1	0	0	0	4595	1821	63	5	3456	5	DMXL2	15	51773566	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	9732440	51773566	50757826	249	2293										
CCPG1	9236	broad.mit.edu	37	chr15	55652875	55652876	+	Frame_Shift_Ins	INS	-	-	T													0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctttgactaagaaagctgtgINSttttttctgcttttcctctt							TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:55652875_55652876insT	uc002acv.1	-	8	1260_1261	c.1095_1096insA	c.(1093-1098)AAACACfs	p.K365fs	CCPG1_uc002acy.2_Frame_Shift_Ins_p.K365fs|CCPG1_uc002acu.1_Frame_Shift_Ins_p.K221fs|CCPG1_uc002acw.1_Frame_Shift_Ins_p.K90fs|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Frame_Shift_Ins_p.K365fs|CCPG1_uc002acz.1_Frame_Shift_Ins_p.K365fs	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	365_366	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		AGAAAGCTGTGTTTTTTCTGCT	0.386																		23	100	---	---								T	55652876	-	T	55652875	7	5	8	1	0	1	1	0	0	0	0	0	2938	1377	48	0	1181	0	CCPG1	15	55652875	Frame_Shift_Ins	INS	-	TCGA-BT-A20N-01A-11D-A14W-08	3879309	55652875	46878517	250	2294										
PYGO1	26108	broad.mit.edu	37	chr15	55839197	55839197	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tatagcctccaaagccaggaTaaccagggccaagatatgga	10	10	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:55839197T>C	uc010bfl.1	-	3	340	c.284A>G	c.(283-285)TAT>TGT	p.Y95C	PYGO1_uc002adf.1_Missense_Mutation_p.Y95C	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	95	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		AAAGCCAGGATAACCAGGGCC	0.448													0	0	0	0.009096	0	3	98										C	55839197	T	C	55839197	3	2	8	1	0	0	0	0	1	0	0	0	12863	1406	49	5	979	5	PYGO1	15	55839197	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	186322	55839197	46692195	251	2295										
DENND4A	10260	broad.mit.edu	37	chr15	66048786	66048786	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgaggccccttgtcttcaatCatcttccattacagaaggtt	7	12	4	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:66048786C>T	uc002aph.2	-	3	381	c.3G>A	c.(1-3)ATG>ATA	p.M1I	DENND4A_uc002api.2_Missense_Mutation_p.M1I|DENND4A_uc002apj.3_Missense_Mutation_p.M1I|DENND4A_uc010ujj.1_Missense_Mutation_p.M1I	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGTCTTCAATCATCTTCCATT	0.358													0	0	0	0.00632	0	26	15										T	66048786	C	T	66048786	3	4	8	1	0	0	0	0	1	0	0	0	4433	826	29	1	5841	1	DENND4A	15	66048786	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	10209589	66048786	36482606	252	2296										
SCAMP5	192683	broad.mit.edu	37	chr15	75305046	75305046	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aacaacttcccaccattgccCaaattcatcccgctgaagcc	4	17	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:75305046C>G	uc002azk.1	+	3	198	c.36C>G	c.(34-36)CCC>CCG	p.P12P	SCAMP5_uc002azl.1_Silent_p.P12P|SCAMP5_uc002azm.1_Silent_p.P12P|SCAMP5_uc002azn.1_Silent_p.P12P|SCAMP5_uc010uly.1_5'UTR	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	12	Cytoplasmic (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						CACCATTGCCCAAATTCATCC	0.512													0	0	0	0.00278	0	24	10										G	75305046	C	G	75305046	2	3	8	1	0	0	0	0	0	0	0	1	13874	581	21	4		4	SCAMP5	15	75305046	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	9256260	75305046	27226346	253	2297										
SCAMP5	192683	broad.mit.edu	37	chr15	75305073	75305073	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atcccgctgaagccatgtttCtaccaagacttcgaggcaga	9	12	1	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:75305073C>T	uc002azk.1	+	3	225	c.63C>T	c.(61-63)TTC>TTT	p.F21F	SCAMP5_uc002azl.1_Silent_p.F21F|SCAMP5_uc002azm.1_Silent_p.F21F|SCAMP5_uc002azn.1_Silent_p.F21F|SCAMP5_uc010uly.1_Silent_p.L3L	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	21	Cytoplasmic (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						AGCCATGTTTCTACCAAGACT	0.527													0	0	0	0.006122	0	18	15										T	75305073	C	T	75305073	2	4	8	1	0	0	0	0	0	0	0	1	13874	912	32	1		1	SCAMP5	15	75305073	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	27	75305073	27226319	254	2298										
IREB2	3658	broad.mit.edu	37	chr15	78758753	78758753	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttgtgattctggagaactagGccgaaactcaggaacatttt	10	7	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:78758753G>T	uc002bdr.2	+	5	713	c.551G>T	c.(550-552)GGC>GTC	p.G184V	IREB2_uc010unb.1_5'UTR|IREB2_uc002bdq.2_Missense_Mutation_p.G184V	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	184							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		GGAGAACTAGGCCGAAACTCA	0.458													1	0	0.000274275	0.004482	0.00028856	8	41										T	78758753	G	T	78758753	3	4	8	1	0	0	0	0	1	0	0	0	7826	1203	42	4	569	4	IREB2	15	78758753	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	3453680	78758753	23772639	255	2299										
MESDC2	23184	broad.mit.edu	37	chr15	81274291	81274291	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gctggttgttgctgctttacCtctggacgtcatagttggca	12	9	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:81274291C>G	uc002bfy.1	-	2	519	c.446G>C	c.(445-447)AGG>ACG	p.R149T	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_Intron	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	149	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						GCTGCTTTACCTCTGGACGTC	0.403													0	0	0	0.001168	0	5	35										G	81274291	C	G	81274291	3	3	8	1	0	0	0	0	1	0	0	0	9481	695	24	4	266	4	MESDC2	15	81274291	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2515538	81274291	21257101	256	2300										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84694106	84694106	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtgcaggtggtgtctccaaGagcatgtgcccctaaagacc	12	11	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:84694106G>C	uc002bjz.3	+	27	4798	c.4574G>C	c.(4573-4575)AGA>ACA	p.R1525T	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.R1525T|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.R1525T	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1525	TSP type-1 9.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTGTCTCCAAGAGCATGTGCC	0.527													0	0	0	0.004672	0	3	23										C	84694106	G	C	84694106	3	2	8	1	0	0	0	0	1	0	0	0	276	942	33	1	4676	1	ADAMTSL3	15	84694106	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	3419815	84694106	17837286	257	2301										
RHCG	51458	broad.mit.edu	37	chr15	90020842	90020842	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aatgccatgcagattgttaaTgccacatgtgtcctggatgt	10	8	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr15:90020842T>A	uc002bnz.2	-	7	1042	c.1018A>T	c.(1018-1020)ATT>TTT	p.I340F	RHCG_uc002bny.2_Missense_Mutation_p.I111F|RHCG_uc002boa.2_Intron	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	340	Cytoplasmic (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					AGATTGTTAATGCCACATGTG	0.592													0	0	0	0.012319	0	21	12										A	90020842	T	A	90020842	3	1	8	1	0	0	0	0	1	0	0	0	13326	1464	51	5	437	5	RHCG	15	90020842	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	5326736	90020842	12510550	258	2302										
ITFG3	83986	broad.mit.edu	37	chr16	310048	310048	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gggagagacctgtggcccaaGacgtggccctcgtggagtgt	17	10	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:310048G>C	uc002cgf.2	+	5	661	c.466G>C	c.(466-468)GAC>CAC	p.D156H	ITFG3_uc010bqr.2_RNA|ITFG3_uc002cgg.2_Missense_Mutation_p.D156H|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.D156H	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	156	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				TGTGGCCCAAGACGTGGCCCT	0.622													0	0	0	0.012213	0	34	21										C	310048	G	C	310048	3	2	8	1	0	0	0	0	1	0	0	0	7871	942	33	1	476	1	ITFG3	16	310048	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		310048	90044705	259	2303										
WDR24	84219	broad.mit.edu	37	chr16	735419	735419	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctgtcgtagagcgcgtgtgaGacagacaggagcgagaagga	17	7	0	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:735419G>C	uc002ciz.1	-	7	2617	c.1857C>G	c.(1855-1857)GTC>GTG	p.V619V	JMJD8_uc002ciw.1_5'Flank|JMJD8_uc002cix.1_5'Flank|JMJD8_uc002ciy.1_5'Flank	NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	749										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				GCGCGTGTGAGACAGACAGGA	0.677													0	0	0	0.000602	0	5	40										C	735419	G	C	735419	2	2	8	1	0	0	0	0	0	0	0	1	17278	929	33	1		1	WDR24	16	735419	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	425371	735419	89619334	260	2304										
NDUFB10	4716	broad.mit.edu	37	chr16	2011251	2011251	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gagtgcaaggaggaggacatCatgtgcatgtatgaagccga	15	6	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:2011251C>T	uc002cni.2	+	2	337	c.228C>T	c.(226-228)ATC>ATT	p.I76I	NDUFB10_uc002cnj.2_Silent_p.I76I	NM_004548	NP_004539	O96000	NDUBA_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	76					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	AGGAGGACATCATGTGCATGT	0.537													0	0	0	0.00623	0	39	27										T	2011251	C	T	2011251	2	4	8	1	0	0	0	0	0	0	0	1	10279	816	29	1		1	NDUFB10	16	2011251	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1275832	2011251	88343502	261	2305										
PAQR4	124222	broad.mit.edu	37	chr16	3019837	3019837	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaactgggcaacatctacacGcacggtgagccgcgtcccgc	12	15	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:3019837G>C	uc002csj.3	+	1	496	c.162G>C	c.(160-162)ACG>ACC	p.T54T	PAQR4_uc002csk.3_Silent_p.T54T|PAQR4_uc002csl.3_Silent_p.T54T|PAQR4_uc010uwm.1_5'Flank	NM_152341	NP_689554	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	54	Helical; (Potential).			T -> A (in Ref. 2; BAC03821).		integral to membrane	receptor activity				0						ACATCTACACGCACGGTGAGC	0.697													0	0	0	0.00245	0	14	14										C	3019837	G	C	3019837	2	2	8	1	0	0	0	0	0	0	0	1	11437	1074	38	4		4	PAQR4	16	3019837	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1008586	3019837	87334916	262	2306										
TNP2	7142	broad.mit.edu	37	chr16	11362858	11362858	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccgcatgggagagtggtgggAgttcatagtctttttgtggc	16	6	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:11362858A>T	uc002das.2	-	1	303	c.262T>A	c.(262-264)TCC>ACC	p.S88T	C16orf75_uc002daq.1_Intron	NM_005425	NP_005416	Q05952	STP2_HUMAN	transition protein 2 (during histone to	88					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding				0						GAGTGGTGGGAGTTCATAGTC	0.557													0	0	0	0.00623	0	39	22										T	11362858	A	T	11362858	3	4	8	1	0	0	0	0	1	0	0	0	16331	304	11	5	162	5	TNP2	16	11362858	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	8343021	11362858	78991895	263	2307										
TMC7	79905	broad.mit.edu	37	chr16	19020681	19020681	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacagaatcgctgaaaacctCagcagccattctcttcgaaa	7	12	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:19020681C>A	uc002dfq.2	+	2	385	c.255C>A	c.(253-255)CTC>CTA	p.L85L	TMC7_uc010vao.1_Silent_p.L85L|TMC7_uc002dfp.2_Silent_p.L85L|TMC7_uc010vap.1_5'UTR	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	85	Extracellular (Potential).					integral to membrane				skin(2)|ovary(1)	3						CTGAAAACCTCAGCAGCCATT	0.493													1	0	6.68952e-21	0.013114	8.23953e-21	46	20										A	19020681	C	A	19020681	2	1	8	1	0	0	0	0	0	0	0	1	15987	813	29	3		3	TMC7	16	19020681	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	7657823	19020681	71334072	264	2308										
THUMPD1	55623	broad.mit.edu	37	chr16	20748467	20748467	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccttagggctcttcaccaccTcctggagattgtattttcta	7	12	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:20748467T>C	uc002dho.2	-	4	935	c.797A>G	c.(796-798)GAG>GGG	p.E266G	THUMPD1_uc010vaz.1_Missense_Mutation_p.E119G|THUMPD1_uc002dhp.2_Missense_Mutation_p.E266G	NM_017736	NP_060206	Q9NXG2	THUM1_HUMAN	THUMP domain containing 1	266											0						CTTCACCACCTCCTGGAGATT	0.428													0	0	0	0.003954	0	23	86										C	20748467	T	C	20748467	3	2	8	1	0	0	0	0	1	0	0	0	15879	1551	54	5	268	5	THUMPD1	16	20748467	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	1727786	20748467	69606286	265	2309										
SEPT1	1731	broad.mit.edu	37	chr16	30392786	30392786	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctcgatgaatttcaccaccGgaagccagctgggtgtgggg	14	11	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:30392786G>A	uc002dxy.2	-	6	501	c.314C>T	c.(313-315)CCG>CTG	p.P105L	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_5'UTR|SEPT1_uc010veq.1_Missense_Mutation_p.P152L	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	105					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TTTCACCACCGGAAGCCAGCT	0.562													0	0	0	0.009096	0	4	114										A	30392786	G	A	30392786	3	1	8	1	0	0	0	0	1	0	0	0	14059	1116	39	2	817	2	SEPT1	16	30392786	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	9644319	30392786	59961967	266	2310										
ITGAD	3681	broad.mit.edu	37	chr16	31429662	31429662	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgatgtctcctacaaggccaCcctgggagacaggatgctta	11	12	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:31429662C>T	uc002ebv.1	+	22	2706	c.2657C>T	c.(2656-2658)ACC>ATC	p.T886I	ITGAD_uc010cap.1_Missense_Mutation_p.T887I	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	886	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TACAAGGCCACCCTGGGAGAC	0.577													0	0	0	0.001984	0	7	96										T	31429662	C	T	31429662	3	4	8	1	0	0	0	0	1	0	0	0	7884	507	18	2	2743	2	ITGAD	16	31429662	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1036876	31429662	58925091	267	2311										
SLC12A4	6560	broad.mit.edu	37	chr16	67985834	67985834	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaggttggggctgtggcagaAgaaactccatagctgggtgg	17	6	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:67985834A>G	uc002euz.2	-	8	1165	c.1024T>C	c.(1024-1026)TTC>CTC	p.F342L	SLC12A4_uc010ceu.2_Missense_Mutation_p.F336L|SLC12A4_uc010vkh.1_Missense_Mutation_p.F311L|SLC12A4_uc010vki.1_Missense_Mutation_p.F342L|SLC12A4_uc010vkj.1_Missense_Mutation_p.F344L|SLC12A4_uc002eva.2_Missense_Mutation_p.F342L|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	342					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGTGGCAGAAGAAACTCCAT	0.577													0	0	0	0.00308	0	7	57										G	67985834	A	G	67985834	3	3	8	1	0	0	0	0	1	0	0	0	14385	72	3	5	2301	5	SLC12A4	16	67985834	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	36556172	67985834	22368919	268	2312										
HAS3	3038	broad.mit.edu	37	chr16	69147356	69147356	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctctgcaggtgtgcgactctGacactgtgctggatccagcc	12	13	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:69147356G>C	uc010cfh.2	+	3	873	c.649G>C	c.(649-651)GAC>CAC	p.D217H	HAS3_uc002ewk.2_Missense_Mutation_p.D217H|HAS3_uc002ewl.2_Missense_Mutation_p.D217H	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	217	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		GTGCGACTCTGACACTGTGCT	0.612											OREG0023905	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	59										C	69147356	G	C	69147356	3	2	8	1	0	0	0	0	1	0	0	0	6963	1290	45	1	655	1	HAS3	16	69147356	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1161522	69147356	21207397	269	2313										
SF3B3	23450	broad.mit.edu	37	chr16	70563070	70563070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgttcctggccagttcttagCtgtggatcccaaagggcgag	13	11	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:70563070C>T	uc002ezf.2	+	3	576	c.365C>T	c.(364-366)GCT>GTT	p.A122V	SNORD111B_uc010cfv.1_5'Flank	NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	122					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CAGTTCTTAGCTGTGGATCCC	0.438													0	0	0	0.009096	0	3	51										T	70563070	C	T	70563070	3	4	8	1	0	0	0	0	1	0	0	0	14152	797	28	2	371	2	SF3B3	16	70563070	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1415714	70563070	19791683	270	2314										
VAT1L	57687	broad.mit.edu	37	chr16	77910312	77910312	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gttttggattgcctctgtggGgacaacactggaaaaggtct	13	7	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:77910312G>T	uc002ffg.1	+	5	865	c.768G>T	c.(766-768)GGG>GGT	p.G256G		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	256							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GCCTCTGTGGGGACAACACTG	0.478													1	0	1.58986e-06	0.008291	1.76457e-06	10	135										T	77910312	G	T	77910312	2	4	8	1	0	0	0	0	0	0	0	1	17127	1219	43	4		4	VAT1L	16	77910312	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	7347242	77910312	12444441	271	2315										
C16orf46	123775	broad.mit.edu	37	chr16	81095726	81095726	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atgcaggcagctggagaagtCcttccccacccttggacctg	11	14	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:81095726C>A	uc002fgc.3	-	4	487	c.228G>T	c.(226-228)AGG>AGT	p.R76S	C16orf46_uc010chf.2_Missense_Mutation_p.R76S|C16orf46_uc010vno.1_5'UTR	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	76											0						CTGGAGAAGTCCTTCCCCACC	0.557													1	0	1.5842e-08	0.001855	1.81308e-08	11	106										A	81095726	C	A	81095726	3	1	8	1	0	0	0	0	1	0	0	0	1815	854	30	3	991	3	C16orf46	16	81095726	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	3185414	81095726	9259027	272	2316										
KIAA0182	23199	broad.mit.edu	37	chr16	85691124	85691124	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagtctcaggtgtccgagttCcggcagcaggtgctggagca	15	11	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr16:85691124C>T	uc002fix.2	+	8	1628	c.1554C>T	c.(1552-1554)TTC>TTT	p.F518F	KIAA0182_uc002fiw.2_Silent_p.F414F|KIAA0182_uc002fiy.2_Silent_p.F445F	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	518							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						TGTCCGAGTTCCGGCAGCAGG	0.697													0	0	0	0.006214	0	9	12										T	85691124	C	T	85691124	2	4	8	1	0	0	0	0	0	0	0	1	8159	854	30	1		1	KIAA0182	16	85691124	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	4595398	85691124	4663629	273	2317										
TP53	7157	broad.mit.edu	37	chr17	7577107	7577107	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtgcgccggtctctcccaggAcaggcacaaacacgcacctc	10	17	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:7577107A>T	uc002gim.2	-	8	1025	c.831T>A	c.(829-831)TGT>TGA	p.C277*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.C277*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.C145*|TP53_uc010cng.1_Nonsense_Mutation_p.C145*|TP53_uc002gii.1_Nonsense_Mutation_p.C145*|TP53_uc010cnh.1_Nonsense_Mutation_p.C277*|TP53_uc010cni.1_Nonsense_Mutation_p.C277*|TP53_uc002gij.2_Nonsense_Mutation_p.C277*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	277	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> W (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> Y (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C277F(20)|p.C277Y(15)|p.0?(7)|p.C277*(6)|p.C277G(4)|p.C277C(4)|p.P278fs*28(2)|p.?(2)|p.C277W(2)|p.C277fs*29(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.C277_P278insXXXXXXX(1)|p.L265_K305del41(1)|p.C275_R283delCACPGRDRR(1)|p.S269fs*21(1)|p.F270_D281del12(1)|p.A276_C277delAC(1)|p.C275fs*67(1)|p.C277R(1)|p.C277S(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCTCCCAGGACAGGCACAAA	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.004007	0	17	14										T	7577107	A	T	7577107	4	4	8	1	0	0	0	0	0	1	0	0	16378	273	10	5	455	5	TP53	17	7577107	Nonsense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08		7577107	73618103	274	2318										
MYH13	8735	broad.mit.edu	37	chr17	10248889	10248889	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtgaccatccacaggaacatCttctcgtagacggctttggc	10	12	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:10248889C>A	uc002gmk.1	-	14	1398	c.1308G>T	c.(1306-1308)AAG>AAT	p.K436N	MYH13_uc010vvf.1_Missense_Mutation_p.K111N	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	436	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACAGGAACATCTTCTCGTAGA	0.517													1	0	5.85753e-14	0.01441	6.98066e-14	44	42										A	10248889	C	A	10248889	3	1	8	1	0	0	0	0	1	0	0	0	10032	912	32	3	4620	3	MYH13	17	10248889	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	2671782	10248889	70946321	275	2319										
AKAP10	11216	broad.mit.edu	37	chr17	19845219	19845219	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtccatcttctccacaaatCcttgctgcaaaagaagttgt	6	11	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:19845219C>T	uc002gwo.2	-	6	1118	c.981G>A	c.(979-981)AGG>AGA	p.R327R	AKAP10_uc002gwp.1_Silent_p.R327R|AKAP10_uc010cqw.1_Silent_p.R327R	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	327	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CTCCACAAATCCTTGCTGCAA	0.373													0	0	0	0.000602	0	4	25										T	19845219	C	T	19845219	2	4	8	1	0	0	0	0	0	0	0	1	446	854	30	1		1	AKAP10	17	19845219	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	9596330	19845219	61349991	276	2320										
NOS2	4843	broad.mit.edu	37	chr17	26106004	26106004	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gggcaccctgggaactccagGccgcccacctcaagcagcat	11	17	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:26106004G>T	uc002gzu.2	-	10	1347	c.1083C>A	c.(1081-1083)GGC>GGA	p.G361G	NOS2_uc010crh.1_Silent_p.G361G|NOS2_uc010wab.1_Silent_p.G361G	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	361					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GGAACTCCAGGCCGCCCACCT	0.567													1	0	1.39649e-27	0.012213	1.73062e-27	30	40										T	26106004	G	T	26106004	2	4	8	1	0	0	0	0	0	0	0	1	10543	1190	42	4		4	NOS2	17	26106004	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6260785	26106004	55089206	277	2321										
EFCAB5	374786	broad.mit.edu	37	chr17	28380773	28380773	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagaacaaggatcaagcagaGagtcagttgcagaacaaggg	13	7	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:28380773G>C	uc002het.2	+	10	1993	c.1801G>C	c.(1801-1803)GAG>CAG	p.E601Q	EFCAB5_uc010wbi.1_Missense_Mutation_p.E344Q|EFCAB5_uc010wbj.1_Missense_Mutation_p.E545Q|EFCAB5_uc010wbk.1_Missense_Mutation_p.E258Q|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.E480Q|EFCAB5_uc010csf.2_Missense_Mutation_p.E480Q	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	601							calcium ion binding			ovary(1)|skin(1)	2						ATCAAGCAGAGAGTCAGTTGC	0.478													0	0	0	0.013537	0	12	109										C	28380773	G	C	28380773	3	2	8	1	0	0	0	0	1	0	0	0	4938	943	33	1	1839	1	EFCAB5	17	28380773	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	2274769	28380773	52814437	278	2322										
GAS2L2	246176	broad.mit.edu	37	chr17	34071981	34071981	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aatggagcggctggctctttCtcctcctttccttcctcctc	7	16	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:34071981C>T	uc002hjv.1	-	6	2563	c.2535G>A	c.(2533-2535)GAG>GAA	p.E845E		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	845					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGctctttctcctcctttc	0.512													0	0	0	0.000602	0	4	20										T	34071981	C	T	34071981	2	4	8	1	0	0	0	0	0	0	0	1	6247	912	32	1		1	GAS2L2	17	34071981	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	5691208	34071981	47123229	279	2323										
ABCC3	8714	broad.mit.edu	37	chr17	48761083	48761083	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gggcctagacctggtgctgaGagacctgagtctgcatgtgc	15	10	1	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:48761083G>C	uc002isl.2	+	27	4000	c.3920G>C	c.(3919-3921)AGA>ACA	p.R1307T	ABCC3_uc002isn.2_Missense_Mutation_p.R61T	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1307	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CTGGTGCTGAGAGACCTGAGT	0.647													0	0	0	0.010818	0	30	81										C	48761083	G	C	48761083	3	2	8	1	0	0	0	0	1	0	0	0	54	942	33	1	4110	1	ABCC3	17	48761083	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	14689102	48761083	32434127	280	2324										
UTP18	51096	broad.mit.edu	37	chr17	49357465	49357465	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tttgcatttgctagcaatgaAggtaaagcattattattgct	8	5	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:49357465A>C	uc002its.2	+	8	1161	c.1112A>C	c.(1111-1113)AAG>ACG	p.K371T		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	371	WD 3.				rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			CTAGCAATGAAGGTAAAGCAT	0.418													0	0	0	0.004007	0	16	24										C	49357465	A	C	49357465	3	2	8	1	0	0	0	0	1	0	0	0	17095	86	3	5	1142	5	UTP18	17	49357465	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	596382	49357465	31837745	281	2325										
ACE	1636	broad.mit.edu	37	chr17	61566424	61566424	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acctgcatgcctacgtgcgcCgggccctgcaccgtcactac	10	18	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:61566424C>T	uc002jau.1	+	17	2594	c.2572C>T	c.(2572-2574)CGG>TGG	p.R858W	ACE_uc002jav.1_Missense_Mutation_p.R284W|ACE_uc010ddv.1_Missense_Mutation_p.R85W|ACE_uc010wpj.1_Missense_Mutation_p.R284W|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Intron	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	858	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CTACGTGCGCCGGGCCCTGCA	0.632													0	0	0	0.004672	0	3	39										T	61566424	C	T	61566424	3	4	8	1	0	0	0	0	1	0	0	0	136	643	23	2	2841	2	ACE	17	61566424	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	12208959	61566424	19628786	282	2326										
KCNJ16	3773	broad.mit.edu	37	chr17	68128659	68128659	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctgtgttactgaagaatgttCtgtggccgtgctcatggtga	13	7	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:68128659C>A	uc002jin.2	+	5	917	c.431C>A	c.(430-432)TCT>TAT	p.S144Y	KCNJ16_uc002jio.2_Missense_Mutation_p.S144Y|KCNJ16_uc002jip.2_Missense_Mutation_p.S144Y|KCNJ16_uc002jiq.2_Missense_Mutation_p.S176Y	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	144	Extracellular (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					GAAGAATGTTCTGTGGCCGTG	0.458													1	0	7.41877e-09	0.012319	8.51473e-09	23	41										A	68128659	C	A	68128659	3	1	8	1	0	0	0	0	1	0	0	0	8050	913	32	3	433	3	KCNJ16	17	68128659	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6562235	68128659	13066551	283	2327										
CD300A	11314	broad.mit.edu	37	chr17	72480186	72480186	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgcctcggtggtgtttgattCtaacaccaacaggatagctg	11	9	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:72480186C>T	uc002jkv.2	+	7	1142	c.821C>T	c.(820-822)TCT>TTT	p.S274F	CD300A_uc002jkw.2_Missense_Mutation_p.S161F|CD300A_uc010dfr.2_Missense_Mutation_p.S125F|CD300A_uc010dfs.2_Missense_Mutation_p.S78F	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	274	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						GTGTTTGATTCTAACACCAAC	0.507													0	0	0	0.004656	0	26	60										T	72480186	C	T	72480186	3	4	8	1	0	0	0	0	1	0	0	0	2996	913	32	1	847	1	CD300A	17	72480186	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	4351527	72480186	8715024	284	2328										
KIAA0195	9772	broad.mit.edu	37	chr17	73489627	73489627	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtggtcttagaggcctgcacAgacttctgggacggagctga	15	9	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:73489627A>G	uc002jnz.3	+	17	2417	c.2142A>G	c.(2140-2142)ACA>ACG	p.T714T	KIAA0195_uc010wsa.1_Silent_p.T724T|KIAA0195_uc010wsb.1_Silent_p.T354T|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	714					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGCCTGCACAGACTTCTGGG	0.612													0	0	0	0.00499	0	16	31										G	73489627	A	G	73489627	2	3	8	1	0	0	0	0	0	0	0	1	8160	175	7	5		5	KIAA0195	17	73489627	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	1009441	73489627	7705583	285	2329										
NARF	26502	broad.mit.edu	37	chr17	80426772	80426772	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtggtttcctcaaaagtcttGgtgagtcatcttttgataaa	9	6	4	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr17:80426772G>C	uc002kfg.3	+	4	525	c.385G>C	c.(385-387)GGG>CGG	p.G129R	NARF_uc002kff.3_Missense_Mutation_p.G70R|NARF_uc010wvo.1_Missense_Mutation_p.G129R|NARF_uc010wvp.1_Missense_Mutation_p.L13F|NARF_uc010dit.2_Missense_Mutation_p.G129R|NARF_uc002kfj.3_Missense_Mutation_p.G81R|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Missense_Mutation_p.G129R|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	129						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CAAAAGTCTTGGTGAGTCATC	0.388													0	0	0	0.001168	0	5	78										C	80426772	G	C	80426772	3	2	8	1	0	0	0	0	1	0	0	0	10167	1362	47	4	399	4	NARF	17	80426772	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	6937145	80426772	768438	286	2330										
NDC80	10403	broad.mit.edu	37	chr18	2595619	2595619	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atatgccagaggcaaagaagCggtatgtcataccatttcca	9	9	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr18:2595619C>T	uc002kli.2	+	11	1402	c.1220C>T	c.(1219-1221)GCG>GTG	p.A407V		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	407	Interaction with the N-terminus of CDCA1.|Interaction with PSMC2 and SMC1A.|Interaction with NEK2 and ZWINT.|Interaction with SMC1A.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						GGCAAAGAAGCGGTATGTCAT	0.408													0	0	0	0.004007	0	16	41										T	2595619	C	T	2595619	3	4	8	1	0	0	0	0	1	0	0	0	10242	782	27	2	1258	2	NDC80	18	2595619	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		2595619	75481629	287	2331										
LAMA3	3909	broad.mit.edu	37	chr18	21474922	21474922	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgacctggccaccatgggcgAgcagctccgcctggtcaagt	13	15	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr18:21474922A>T	uc002kuq.2	+	44	5599	c.5513A>T	c.(5512-5514)GAG>GTG	p.E1838V	LAMA3_uc002kur.2_Missense_Mutation_p.E1838V|LAMA3_uc002kus.3_Missense_Mutation_p.E229V|LAMA3_uc002kut.3_Missense_Mutation_p.E229V	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1838	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCATGGGCGAGCAGCTCCGC	0.627													0	0	0	0.009096	0	3	25										T	21474922	A	T	21474922	3	4	8	1	0	0	0	0	1	0	0	0	8607	304	11	5	5862	5	LAMA3	18	21474922	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	18879303	21474922	56602326	288	2332										
ZNF555	148254	broad.mit.edu	37	chr19	2851495	2851495	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctcaatttaaggccagtgggTcagtttctcagcaggatatt	10	8	3	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:2851495T>A	uc002lwo.2	+	3	249	c.160T>A	c.(160-162)TCA>ACA	p.S54T	ZNF555_uc002lwn.3_Missense_Mutation_p.S54T	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCAGTGGGTCAGTTTCTCA	0.388													0	0	0	0.009096	0	3	45										A	2851495	T	A	2851495	3	1	8	1	0	0	0	0	1	0	0	0	17983	1667	58	5	170	5	ZNF555	19	2851495	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08		2851495	56277488	289	2333										
C19orf29	58509	broad.mit.edu	37	chr19	3612107	3612107	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tccttgttgtcggcgcaggcCtccaggaagtactcgggcgt	14	12	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:3612107C>A	uc002lyh.2	-	10	2144	c.2091G>T	c.(2089-2091)GAG>GAT	p.E697D	C19orf29_uc010xho.1_Missense_Mutation_p.E156D|C19orf29_uc010dtn.2_Missense_Mutation_p.E545D|C19orf29_uc002lyi.3_Missense_Mutation_p.E697D|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	697						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCGCAGGCCTCCAGGAAGT	0.582													1	0	3.41278e-10	0.00499	3.98487e-10	17	181										A	3612107	C	A	3612107	3	1	8	1	0	0	0	0	1	0	0	0	1918	680	24	4	189	4	C19orf29	19	3612107	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	760612	3612107	55516876	290	2334										
ECSIT	51295	broad.mit.edu	37	chr19	11624758	11624758	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agctggttgtacacagccagGtcccgctcgacaccatactc	9	15	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:11624758G>C	uc002msb.2	-	3	509	c.375C>G	c.(373-375)GAC>GAG	p.D125E	ECSIT_uc002msa.1_5'Flank|ECSIT_uc010dyc.1_Missense_Mutation_p.D125E|ECSIT_uc010dyd.2_Missense_Mutation_p.D125E|ECSIT_uc010xma.1_Intron	NM_016581	NP_057665	Q9BQ95	ECSIT_HUMAN	evolutionarily conserved signaling intermediate	125					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			ovary(1)	1						ACACAGCCAGGTCCCGCTCGA	0.597													0	0	0	0.001984	0	6	56										C	11624758	G	C	11624758	3	2	8	1	0	0	0	0	1	0	0	0	4900	1252	44	4	944	4	ECSIT	19	11624758	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	8012651	11624758	47504225	291	2335										
ZNF563	147837	broad.mit.edu	37	chr19	12430206	12430206	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gttctttcatgcatacgtaaTaaactgggccaaaaaaaagc	7	8	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:12430206T>C	uc002mtp.2	-	4	871	c.633A>G	c.(631-633)TTA>TTG	p.L211L	ZNF563_uc002mtq.2_Intron	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	211	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCATACGTAATAAACTGGGCC	0.393													0	0	0	0.004007	0	17	142										C	12430206	T	C	12430206	2	2	8	1	0	0	0	0	0	0	0	1	17991	1403	49	5		5	ZNF563	19	12430206	Silent	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	805448	12430206	46698777	292	2336										
OR7A5	26659	broad.mit.edu	37	chr19	14938677	14938677	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtagtgcagggggtgacagAtggccacaaaccggtcatag	15	8	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:14938677A>G	uc002mzw.2	-	1	600	c.377T>C	c.(376-378)ATC>ACC	p.I126T	OR7A5_uc010xoa.1_Missense_Mutation_p.I126T	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						GGGGTGACAGATGGCCACAAA	0.483													0	0	0	0.014323	0	22	38										G	14938677	A	G	14938677	3	3	8	1	0	0	0	0	1	0	0	0	11216	333	12	5	586	5	OR7A5	19	14938677	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	2508471	14938677	44190306	293	2337										
OR10H4	126541	broad.mit.edu	37	chr19	16060285	16060285	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgggctggtggctcagtcatGgggatgatggtgacaacgat	17	6	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:16060285G>A	uc010xov.1	+	1	468	c.468G>A	c.(466-468)ATG>ATA	p.M156I		NM_001004465	NP_001004465	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GCTCAGTCATGGGGATGATGG	0.522													0	0	0	0.010504	0	21	113										A	16060285	G	A	16060285	3	1	8	1	0	0	0	0	1	0	0	0	10908	1348	47	2	470	2	OR10H4	19	16060285	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1121608	16060285	43068698	294	2338										
LSR	51599	broad.mit.edu	37	chr19	35757739	35757739	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	caccacccccctgtccctagAagtccgcagtggctacagga	9	17	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:35757739A>G	uc002nyl.2	+	8	1380	c.1157A>G	c.(1156-1158)GAA>GGA	p.E386G	LSR_uc002nym.2_Missense_Mutation_p.E367G|LSR_uc002nyn.2_Missense_Mutation_p.E318G|LSR_uc002nyo.2_Intron|LSR_uc010xsr.1_Missense_Mutation_p.E278G|LSR_uc002nyp.2_Intron|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	386	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CTGTCCCTAGAAGTCCGCAGT	0.597													0	0	0	0.004482	0	6	6										G	35757739	A	G	35757739	3	3	8	1	0	0	0	0	1	0	0	0	9064	260	9	5	1187	5	LSR	19	35757739	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	19697454	35757739	23371244	295	2339										
CYP2A7	1549	broad.mit.edu	37	chr19	41383813	41383813	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	catagcgcagggtggtgctgAccgtctcggtgcctgcaatg	15	11	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:41383813A>C	uc002opm.2	-	6	1459	c.917T>G	c.(916-918)GTC>GGC	p.V306G	CYP2A7_uc002opo.2_Missense_Mutation_p.V306G|CYP2A7_uc002opn.2_Missense_Mutation_p.V255G	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	306						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GGTGGTGCTGACCGTCTCGGT	0.587													0	0	0	0.010729	0	11	56										C	41383813	A	C	41383813	3	2	8	1	0	0	0	0	1	0	0	0	4163	275	10	5	583	5	CYP2A7	19	41383813	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	5626074	41383813	17745170	296	2340										
FUT1	2523	broad.mit.edu	37	chr19	49253764	49253764	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	catgccgttgctggtgaccaCgaaaacgggggcttcgtgcc	14	12	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:49253764C>G	uc002pkk.2	-	4	1750	c.775G>C	c.(775-777)GTG>CTG	p.V259L		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	259	Lumenal (Potential).		V -> E (in Bombay H-).		L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		CTGGTGACCACGAAAACGGGG	0.617													0	0	0	0.000602	0	5	122										G	49253764	C	G	49253764	3	3	8	1	0	0	0	0	1	0	0	0	6101	536	19	4	326	4	FUT1	19	49253764	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	7869951	49253764	9875219	297	2341										
PLEKHA4	57664	broad.mit.edu	37	chr19	49348658	49348658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gctgtggggaagggaggtggCgaccctcagggctggaagcc	20	9	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:49348658C>T	uc002pkx.2	-	16	2263	c.1712G>A	c.(1711-1713)CGC>CAC	p.R571H	PLEKHA4_uc002pkw.1_Missense_Mutation_p.R86H|PLEKHA4_uc010eml.2_Missense_Mutation_p.R546H	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	571						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		AGGGAGGTGGCGACCCTCAGG	0.582													0	0	0	0.01441	0	55	14										T	49348658	C	T	49348658	3	4	8	1	0	0	0	0	1	0	0	0	12058	768	27	2	647	2	PLEKHA4	19	49348658	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	94894	49348658	9780325	298	2342										
NOSIP	51070	broad.mit.edu	37	chr19	50060221	50060221	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtccttgtccttacttggagGacccacactgggcccaggtt	11	13	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:50060221G>A	uc002pok.2	-	7	600	c.448C>T	c.(448-450)CCT>TCT	p.P150S	NOSIP_uc002pol.2_Missense_Mutation_p.P150S|NOSIP_uc010yay.1_RNA	NM_015953	NP_057037	Q9Y314	NOSIP_HUMAN	nitric oxide synthase interacting protein	150					negative regulation of nitric-oxide synthase activity|nitric oxide metabolic process	cytosol|nucleus	protein binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00321)|GBM - Glioblastoma multiforme(134;0.0133)		TTACTTGGAGGACCCACACTG	0.478													0	0	0	0.000602	0	5	9										A	50060221	G	A	50060221	3	1	8	1	0	0	0	0	1	0	0	0	10545	1174	41	1	473	1	NOSIP	19	50060221	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	711563	50060221	9068762	299	2343										
GPR32	2854	broad.mit.edu	37	chr19	51274695	51274695	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acgtggtgctgttggtccatCtgtggcgacgggtgatgctc	16	9	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:51274695C>T	uc010ycf.1	+	1	838	c.838C>T	c.(838-840)CTG>TTG	p.L280L		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	280	Helical; Name=6; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GTTGGTCCATCTGTGGCGACG	0.592													0	0	0	0.01441	0	81	25										T	51274695	C	T	51274695	2	4	8	1	0	0	0	0	0	0	0	1	6688	912	32	1		1	GPR32	19	51274695	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1214474	51274695	7854288	300	2344										
VSTM1	284415	broad.mit.edu	37	chr19	54561828	54561828	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctgggccaggcgtggagggaGggcttgggcggtttctctgg	21	8	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:54561828G>A	uc002qcw.3	-	3	263	c.87C>T	c.(85-87)CCC>CCT	p.P29P	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Silent_p.P29P	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	29	Ig-like V-type.					integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		CGTGGAGGGAGGGCTTGGGCG	0.498													0	0	0	0.008291	0	10	70										A	54561828	G	A	54561828	2	1	8	1	0	0	0	0	0	0	0	1	17225	987	35	2		2	VSTM1	19	54561828	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	3287133	54561828	4567155	301	2345										
NLRP7	199713	broad.mit.edu	37	chr19	55450590	55450590	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gccaaaagtggcctccaactCcttggctctcttctcgttag	8	14	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:55450590C>G	uc002qih.3	-	4	1673	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	NLRP7_uc002qig.3_Missense_Mutation_p.E533Q|NLRP7_uc002qii.3_Missense_Mutation_p.E533Q|NLRP7_uc010esk.2_Missense_Mutation_p.E533Q|NLRP7_uc010esl.2_Missense_Mutation_p.E561Q	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	533							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GCCTCCAACTCCTTGGCTCTC	0.498													0	0	0	0.004672	0	3	66										G	55450590	C	G	55450590	3	3	8	1	0	0	0	0	1	0	0	0	10482	864	30	1	1548	1	NLRP7	19	55450590	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	888762	55450590	3678393	302	2346										
U2AF2	11338	broad.mit.edu	37	chr19	56181003	56181003	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cagcaagtacgggcttgtcaAgtccatcgagatcccccggc	11	14	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:56181003A>G	uc002qlu.2	+	11	2293	c.1238A>G	c.(1237-1239)AAG>AGG	p.K413R	U2AF2_uc002qlt.2_Missense_Mutation_p.K409R	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	413	RRM 3.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		GGGCTTGTCAAGTCCATCGAG	0.567													0	0	0	0.00632	0	23	12										G	56181003	A	G	56181003	3	3	8	1	0	0	0	0	1	0	0	0	16820	72	3	5	1280	5	U2AF2	19	56181003	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	730413	56181003	2947980	303	2347										
NLRP4	147945	broad.mit.edu	37	chr19	56369479	56369479	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gaagagctgcagggcggcttGaacgaacccgattcggatct	14	10	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:56369479G>C	uc002qmd.3	+	3	1142	c.720G>C	c.(718-720)TTG>TTC	p.L240F	NLRP4_uc002qmf.2_Missense_Mutation_p.L165F|NLRP4_uc010etf.2_Missense_Mutation_p.L71F	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	240	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AGGGCGGCTTGAACGAACCCG	0.567													0	0	0	0.005443	0	26	61										C	56369479	G	C	56369479	3	2	8	1	0	0	0	0	1	0	0	0	10479	1281	45	1	726	1	NLRP4	19	56369479	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	188476	56369479	2759504	304	2348										
ZIM2	23619	broad.mit.edu	37	chr19	57286539	57286539	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgtctgttgaggtgtggcatGagatagaaggcttcagcaca	14	6	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:57286539G>C	uc002qnr.2	-	11	1483	c.1101C>G	c.(1099-1101)CTC>CTG	p.L367L	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Silent_p.L163L|ZIM2_uc010ygr.1_Silent_p.L163L|ZIM2_uc002qnq.2_Silent_p.L367L|ZIM2_uc010etp.2_Silent_p.L367L|ZIM2_uc010ygs.1_Silent_p.L367L	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	367	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		GGTGTGGCATGAGATAGAAGG	0.478													0	0	0	0.00308	0	6	96										C	57286539	G	C	57286539	2	2	8	1	0	0	0	0	0	0	0	1	17681	1277	45	1		1	ZIM2	19	57286539	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	917060	57286539	1842444	305	2349										
ZNF418	147686	broad.mit.edu	37	chr19	58438177	58438177	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctaaataatttcctacactCtctacactcataaggccttt	2	13	2	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr19:58438177C>G	uc002qqs.1	-	4	1664	c.1372G>C	c.(1372-1374)GAG>CAG	p.E458Q	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.E373Q	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	458	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TTCCTACACTCTCTACACTCA	0.443													0	0	0	0.01441	0	96	44										G	58438177	C	G	58438177	3	3	8	1	0	0	0	0	1	0	0	0	17892	922	32	1	662	1	ZNF418	19	58438177	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1151638	58438177	690806	306	2350										
FASTKD5	60493	broad.mit.edu	37	chr20	3127517	3127517	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccattcccagtaggataactCtaccacacggtagccaagcc	7	15	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:3127517C>G	uc002whz.2	-	2	2511	c.2200G>C	c.(2200-2202)GAG>CAG	p.E734Q	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	734	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						TAGGATAACTCTACCACACGG	0.502													0	0	0	0.01441	0	48	55										G	3127517	C	G	3127517	3	3	8	1	0	0	0	0	1	0	0	0	5688	922	32	1	98	1	FASTKD5	20	3127517	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08		3127517	59898003	307	2351										
ANKRD5	63926	broad.mit.edu	37	chr20	10030758	10030758	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tctgaaaaaggcctttgaatCaggaatacctgtggatatga	10	6	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:10030758C>A	uc002wno.2	+	7	1934	c.1541C>A	c.(1540-1542)TCA>TAA	p.S514*	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Nonsense_Mutation_p.S514*|ANKRD5_uc010gbz.2_Nonsense_Mutation_p.S325*	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	514							calcium ion binding			ovary(1)|breast(1)	2						GCCTTTGAATCAGGAATACCT	0.378													1	0	1.12685e-05	0.004482	1.22708e-05	8	46										A	10030758	C	A	10030758	4	1	8	1	0	0	0	0	0	1	0	0	676	838	29	3	1559	3	ANKRD5	20	10030758	Nonsense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	6903241	10030758	52994762	308	2352										
BCL2L1	598	broad.mit.edu	37	chr20	30309576	30309576	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ctacgctttccacgcacagtGccccgccgaaggagaaaaag	10	14	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:30309576G>T	uc002wwl.2	-	2	812	c.446C>A	c.(445-447)GCA>GAA	p.A149E	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Intron|BCL2L1_uc002wwn.2_Missense_Mutation_p.A149E|BCL2L1_uc002wwo.1_Missense_Mutation_p.A149E	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	149					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CACGCACAGTGCCCCGCCGAA	0.537													1	0	3.07112e-06	0.010729	3.37155e-06	9	175										T	30309576	G	T	30309576	3	4	8	1	0	0	0	0	1	0	0	0	1367	1319	46	4	263	4	BCL2L1	20	30309576	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	20278818	30309576	32715944	309	2353										
TM9SF4	9777	broad.mit.edu	37	chr20	30723942	30723942	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tattcactgcccttctgccaGcccagcaagataacctacaa	5	15	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:30723942G>C	uc002wxj.2	+	3	430	c.195G>C	c.(193-195)CAG>CAC	p.Q65H	TM9SF4_uc010ztr.1_5'UTR|TM9SF4_uc010zts.1_5'UTR|TM9SF4_uc002wxk.2_Missense_Mutation_p.Q48H	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	65						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCTTCTGCCAGCCCAGCAAGA	0.483													0	0	0	0.001168	0	5	44										C	30723942	G	C	30723942	3	2	8	1	0	0	0	0	1	0	0	0	15977	962	34	4	205	4	TM9SF4	20	30723942	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	414366	30723942	32301578	310	2354										
SNTA1	6640	broad.mit.edu	37	chr20	32026723	32026723	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gtagcagaggacaagtcttcCccattcacagacaggatggc	11	11	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:32026723C>G	uc002wzd.1	-	2	692	c.420G>C	c.(418-420)GGG>GGC	p.G140G	SNTA1_uc010zuf.1_Silent_p.G140G	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	140	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						ACAAGTCTTCCCCATTCACAG	0.532													0	0	0	0.010729	0	11	141										G	32026723	C	G	32026723	2	3	8	1	0	0	0	0	0	0	0	1	14871	610	22	4		4	SNTA1	20	32026723	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1302781	32026723	30998797	311	2355										
PTPRT	11122	broad.mit.edu	37	chr20	41400092	41400092	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tacctggagccaaagcttgtCatgctgagaccacttcccac	8	14	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:41400092C>T	uc002xkg.2	-	5	851	c.667G>A	c.(667-669)GAC>AAC	p.D223N	PTPRT_uc010ggj.2_Missense_Mutation_p.D223N	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	223	Extracellular (Potential).|Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CAAAGCTTGTCATGCTGAGAC	0.418													0	0	0	0.009096	0	4	163										T	41400092	C	T	41400092	3	4	8	1	0	0	0	0	1	0	0	0	12812	826	29	1	3827	1	PTPRT	20	41400092	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	9373369	41400092	21625428	312	2356										
TFAP2C	7022	broad.mit.edu	37	chr20	55212966	55212966	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tgccctgcagaactacatcaAagaagccctgattgtcatag	8	11	2	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr20:55212966A>T	uc002xya.2	+	7	1493	c.1250A>T	c.(1249-1251)AAA>ATA	p.K417I	TFAP2C_uc010zzi.1_Missense_Mutation_p.K248I	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	417	H-S-H (helix-span-helix), dimerization.				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			AACTACATCAAAGAAGCCCTG	0.488													0	0	0	0.000602	0	5	71										T	55212966	A	T	55212966	3	4	8	1	0	0	0	0	1	0	0	0	15786	14	1	5	1276	5	TFAP2C	20	55212966	Missense_Mutation	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	13812874	55212966	7812554	313	2357										
KRTAP22-1	337979	broad.mit.edu	37	chr21	31973474	31973474	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	caactaccatggtggccaggGctatgccaaaggaggcctgg	14	11	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:31973474G>T	uc011add.1	+	1	35	c.35G>T	c.(34-36)GGC>GTC	p.G12V	KRTAP6-2_uc011adc.1_5'Flank	NM_181620	NP_853651	Q3MIV0	KR221_HUMAN	keratin associated protein 22-1	12						intermediate filament					0						GGTGGCCAGGGCTATGCCAAA	0.443													1	0	1.45844e-13	0.013726	1.73296e-13	34	96										T	31973474	G	T	31973474	3	4	8	1	0	0	0	0	1	0	0	0	8540	1203	42	4	37	4	KRTAP22-1	21	31973474	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		31973474	16156421	314	2358										
KCNJ6	3763	broad.mit.edu	37	chr21	39087121	39087121	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tctccccgtatgtatgcgatCaaccaccagatcattccaaa	5	14	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:39087121C>G	uc011aej.1	-	3	392	c.339G>C	c.(337-339)TTG>TTC	p.L113F	KCNJ6_uc002ywo.2_Missense_Mutation_p.L113F	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	113	Helical; Name=M1; (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	TGTATGCGATCAACCACCAGA	0.453													0	0	0	0.01441	0	60	128										G	39087121	C	G	39087121	3	3	8	1	0	0	0	0	1	0	0	0	8055	825	29	1	940	1	KCNJ6	21	39087121	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	7113647	39087121	9042774	315	2359										
LCA5L	150082	broad.mit.edu	37	chr21	40794949	40794949	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttttgttgtgataatagataAtttatgagtgagttcttccc	8	4	1	4			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:40794949A>G	uc002yxu.2	-	5	1103	c.790T>C	c.(790-792)TTA>CTA	p.L264L	LCA5L_uc002yxv.2_Silent_p.L264L|LCA5L_uc002yxw.1_Silent_p.L264L|LCA5L_uc002yxx.1_Silent_p.L126L|LCA5L_uc002yxy.2_RNA	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	264											0		Prostate(19;1.2e-06)				ATAATAGATAATTTATGAGTG	0.373													0	0	0	0.004672	0	3	159										G	40794949	A	G	40794949	2	3	8	1	0	0	0	0	0	0	0	1	8657	98	4	5		5	LCA5L	21	40794949	Silent	SNP	A	TCGA-BT-A20N-01A-11D-A14W-08	1707828	40794949	7334946	316	2360										
DSCAM	1826	broad.mit.edu	37	chr21	42080497	42080497	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aggagggaaggggaaaatttGgagagtgccgttggggtgga	21	2	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:42080497G>A	uc002yyq.1	-	2	696	c.244C>T	c.(244-246)CAA>TAA	p.Q82*	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	82	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGGAAAATTTGGAGAGTGCCG	0.502													0	0	0	0.004007	0	14	144										A	42080497	G	A	42080497	4	1	8	1	0	0	0	0	0	1	0	0	4768	1357	47	2	5922	2	DSCAM	21	42080497	Nonsense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1285548	42080497	6049398	317	2361										
RIPK4	54101	broad.mit.edu	37	chr21	43161781	43161781	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttgaccgaggcgttcttctcCaacagcagccgtgtgctaga	11	12	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:43161781C>T	uc002yzn.1	-	8	1620	c.1572G>A	c.(1570-1572)TTG>TTA	p.L524L		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	524						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CGTTCTTCTCCAACAGCAGCC	0.622													0	0	0	0.00278	0	23	80										T	43161781	C	T	43161781	2	4	8	1	0	0	0	0	0	0	0	1	13383	593	21	2		2	RIPK4	21	43161781	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1081284	43161781	4968114	318	2362										
PRDM15	63977	broad.mit.edu	37	chr21	43221851	43221851	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgactgagctcgatggtgtgGtcacatttgggtcacccagg	14	10	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:43221851G>T	uc002yzq.1	-	31	4184	c.4073C>A	c.(4072-4074)ACC>AAC	p.T1358N	PRDM15_uc002yzo.2_Missense_Mutation_p.T1029N|PRDM15_uc002yzp.2_Missense_Mutation_p.T1049N|PRDM15_uc002yzr.1_Missense_Mutation_p.T1049N	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGATGGTGTGGTCACATTTGG	0.557													1	0	1.23904e-05	0.000602	1.34202e-05	4	77										T	43221851	G	T	43221851	3	4	8	1	0	0	0	0	1	0	0	0	12456	1261	44	4	454	4	PRDM15	21	43221851	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	60070	43221851	4908044	319	2363										
MCM3AP	8888	broad.mit.edu	37	chr21	47655203	47655203	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	caaatgtccaccatgtctagCagcgcagagagatggagctc	11	11	1	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr21:47655203C>A	uc002zir.1	-	28	5958	c.5922G>T	c.(5920-5922)CTG>CTT	p.L1974L	MCM3APAS_uc002zim.2_Intron|MCM3APAS_uc002zin.2_Intron|MCM3AP_uc002zio.1_Silent_p.L469L|MCM3AP_uc002zip.1_Silent_p.L715L|MCM3AP_uc002ziq.1_Silent_p.L901L|MCM3APAS_uc002zis.1_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1974					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CCATGTCTAGCAGCGCAGAGA	0.507													1	0	0.00024832	0.009096	0.000262621	4	68										A	47655203	C	A	47655203	2	1	8	1	0	0	0	0	0	0	0	1	9388	697	25	4		4	MCM3AP	21	47655203	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	4433352	47655203	474692	320	2364										
POLR2F	5435	broad.mit.edu	37	chr22	38355472	38355472	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cgcgtgctgggcacccgagcGctccagattgcgtgagtgat	15	12	0	3			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:38355472G>T	uc003aul.2	+	3	331	c.210G>T	c.(208-210)GCG>GCT	p.A70A	POLR2F_uc010gxi.2_Missense_Mutation_p.A64S|POLR2F_uc003aum.2_RNA	NM_021974	NP_068809	P61218	RPAB2_HUMAN	DNA directed RNA polymerase II polypeptide F	70					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)	1	Melanoma(58;0.045)					GCACCCGAGCGCTCCAGATTG	0.587													1	0	3.65163e-15	0.00632	4.36467e-15	26	121										T	38355472	G	T	38355472	2	4	8	1	0	0	0	0	0	0	0	1	12219	1074	38	4		4	POLR2F	22	38355472	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		38355472	12949094	321	2365										
TAB1	10454	broad.mit.edu	37	chr22	39817833	39817833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ttccactctctccccatagcGctgccaagtccaaaccaatc	4	18	1	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:39817833G>A	uc003axt.2	+	8	827	c.778G>A	c.(778-780)GCT>ACT	p.A260T	TAB1_uc003axr.2_Missense_Mutation_p.A336T|TAB1_uc011aok.1_Missense_Mutation_p.A94T|TAB1_uc003axu.1_Missense_Mutation_p.A260T	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	260	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						TCCCCATAGCGCTGCCAAGTC	0.547													0	0	0	0.006214	0	8	34										A	39817833	G	A	39817833	3	1	8	1	0	0	0	0	1	0	0	0	15492	1101	38	2	808	2	TAB1	22	39817833	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	1462361	39817833	11486733	322	2366										
FAM83F	113828	broad.mit.edu	37	chr22	40415273	40415273	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccagtgtacatcatcctggaCgaggcaggagtgaagtattt	12	8	1	1	rs141929176		TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:40415273C>T	uc003ayk.1	+	2	685	c.591C>T	c.(589-591)GAC>GAT	p.D197D		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	197										breast(1)	1						TCATCCTGGACGAGGCAGGAG	0.527													0	0	0	0.010729	0	12	59										T	40415273	C	T	40415273	2	4	8	1	0	0	0	0	0	0	0	1	5638	535	19	2		2	FAM83F	22	40415273	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	597440	40415273	10889293	323	2367										
ZC3H7B	23264	broad.mit.edu	37	chr22	41752423	41752423	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	cctggagaagggacccccatCagttctcgggaaggggagaa	15	10	2	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:41752423C>T	uc003azw.2	+	21	2676	c.2460C>T	c.(2458-2460)ATC>ATT	p.I820I	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	836					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GGACCCCCATCAGTTCTCGGG	0.617													0	0	0	0.014323	0	22	139										T	41752423	C	T	41752423	2	4	8	1	0	0	0	0	0	0	0	1	17570	816	29	1		1	ZC3H7B	22	41752423	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	1337150	41752423	9552143	324	2368										
ZC3H7B	23264	broad.mit.edu	37	chr22	41753225	41753225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	agatggggacaagtgccgctGcgcccatggacaggaggagc	17	10	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:41753225G>A	uc003azw.2	+	23	2942	c.2726G>A	c.(2725-2727)TGC>TAC	p.C909Y	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	925	C3H1-type 4.|Potential.				interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						AAGTGCCGCTGCGCCCATGGA	0.662													0	0	0	0.001168	0	6	38										A	41753225	G	A	41753225	3	1	8	1	0	0	0	0	1	0	0	0	17570	1319	46	2	2812	2	ZC3H7B	22	41753225	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	802	41753225	9551341	325	2369										
ACO2	50	broad.mit.edu	37	chr22	41923345	41923345	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gagaactacggcgagggctcGagccgggagcatgcagctct	16	11	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:41923345G>C	uc003bac.2	+	16	2029	c.2007G>C	c.(2005-2007)TCG>TCC	p.S669S	ACO2_uc003bad.2_Silent_p.S694S|POLR3H_uc003bae.2_RNA|POLR3H_uc003baf.2_3'UTR|POLR3H_uc003bag.2_3'UTR|POLR3H_uc003bai.2_3'UTR	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	669					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						GCGAGGGCTCGAGCCGGGAGC	0.617											OREG0026589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	19	17										C	41923345	G	C	41923345	2	2	8	1	0	0	0	0	0	0	0	1	147	1045	37	1		1	ACO2	22	41923345	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	170120	41923345	9381221	326	2370										
TCF20	6942	broad.mit.edu	37	chr22	42606218	42606218	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	caaaccaggtgccccataacCgaagactctgtcacaacagg	8	14	2	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:42606218C>A	uc003bcj.1	-	1	5228	c.5094G>T	c.(5092-5094)TCG>TCT	p.S1698S	TCF20_uc003bck.1_Silent_p.S1698S|TCF20_uc003bnt.2_Silent_p.S1698S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1698					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GCCCCATAACCGAAGACTCTG	0.557													1	0	1.56452e-12	0.007413	1.84276e-12	17	64										A	42606218	C	A	42606218	2	1	8	1	0	0	0	0	0	0	0	1	15687	639	23	4		4	TCF20	22	42606218	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	682873	42606218	8698348	327	2371										
SELO	83642	broad.mit.edu	37	chr22	50649091	50649091	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	accacgtgtgcaatgcctccGacaacaccggccgctacgcg	10	17	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:50649091G>A	uc011arr.1	+	5	1160	c.1102G>A	c.(1102-1104)GAC>AAC	p.D368N	SELO_uc010hap.2_Missense_Mutation_p.D179N|SELO_uc003bjy.2_Missense_Mutation_p.D48N|SELO_uc003bjz.2_Missense_Mutation_p.D48N	NM_031454	NP_113642	Q9BVL4	SELO_HUMAN	selenoprotein O	368											0		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CAATGCCTCCGACAACACCGG	0.672											OREG0026676	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	24	35										A	50649091	G	A	50649091	3	1	8	1	0	0	0	0	1	0	0	0	14018	1058	37	1	1120	1	SELO	22	50649091	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	8042873	50649091	655475	328	2372										
MIOX	55586	broad.mit.edu	37	chr22	50927504	50927504	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	gacaccttccccgtcggatgCcgtccgcaggcctccgtggt	12	17	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chr22:50927504C>T	uc003bll.1	+	6	558	c.444C>T	c.(442-444)TGC>TGT	p.C148C	MIOX_uc003blm.1_Silent_p.C148C|MIOX_uc003bln.1_Missense_Mutation_p.A159V	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	148					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCGTCGGATGCCGTCCGCAGG	0.667													0	0	0	0.009096	0	3	7										T	50927504	C	T	50927504	2	4	8	1	0	0	0	0	0	0	0	1	9590	747	26	2		2	MIOX	22	50927504	Silent	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	278413	50927504	377062	329	2373										
CCNB3	85417	broad.mit.edu	37	chrX	50094645	50094645	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aaaatccctgccttggatatGttgaagctggaggagatttt	11	6	0	2			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:50094645G>T	uc004dox.3	+	13	4429	c.4131G>T	c.(4129-4131)ATG>ATT	p.M1377I	CCNB3_uc004doy.2_Missense_Mutation_p.M1377I|CCNB3_uc004doz.2_Missense_Mutation_p.M273I|CCNB3_uc010njq.2_Missense_Mutation_p.M269I|CCNB3_uc004dpa.2_Missense_Mutation_p.M216I	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1377					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CCTTGGATATGTTGAAGCTGG	0.473													1	0	3.09899e-07	0.004482	3.46812e-07	7	12										T	50094645	G	T	50094645	3	4	8	1	0	0	0	0	1	0	0	0	2914	1377	48	4	4173	4	CCNB3	23	50094645	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08		50094645	105175915	330	2374										
TGIF2LX	90316	broad.mit.edu	37	chrX	89177393	89177393	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	atttctaactggtttatcaaTgctcgcagacgcattctccc	6	12	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:89177393T>A	uc004efe.2	+	2	358	c.309T>A	c.(307-309)AAT>AAA	p.N103K		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	103	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GGTTTATCAATGCTCGCAGAC	0.473													0	0	0	0.014323	0	23	88										A	89177393	T	A	89177393	3	1	8	1	0	0	0	0	1	0	0	0	15824	1461	51	5	311	5	TGIF2LX	23	89177393	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	39082748	89177393	66093167	331	2375										
COL4A6	1288	broad.mit.edu	37	chrX	107413848	107413848	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	aatacacatacctttgggtcCtattaatccgggggatccta	8	10	0	0			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:107413848C>T	uc004enw.3	-	35	3590	c.3487G>A	c.(3487-3489)GGA>AGA	p.G1163R	COL4A6_uc004env.3_Missense_Mutation_p.G1162R|COL4A6_uc011msn.1_Missense_Mutation_p.G1162R|COL4A6_uc010npk.2_Missense_Mutation_p.G1162R	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1163	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CCTTTGGGTCCTATTAATCCG	0.498									Alport_syndrome_with_Diffuse_Leiomyomatosis				0	0	0	0.009718	0	36	56										T	107413848	C	T	107413848	3	4	8	1	0	0	0	0	1	0	0	0	3695	690	24	2	1632	2	COL4A6	23	107413848	Missense_Mutation	SNP	C	TCGA-BT-A20N-01A-11D-A14W-08	18236455	107413848	47856712	332	2376										
COL4A5	1287	broad.mit.edu	37	chrX	107850090	107850090	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	acctccgggtcctccaggacGcactggcttagatgggctcc	12	15	0	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:107850090G>A	uc004enz.1	+	29	2565	c.2363G>A	c.(2362-2364)CGC>CAC	p.R788H	COL4A5_uc011mso.1_Missense_Mutation_p.R788H|COL4A5_uc004eob.1_Missense_Mutation_p.R396H	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	788	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CCTCCAGGACGCACTGGCTTA	0.517									Alport_syndrome_with_Diffuse_Leiomyomatosis				0	0	0	0.008871	0	19	17										A	107850090	G	A	107850090	3	1	8	1	0	0	0	0	1	0	0	0	3694	1087	38	2	2477	2	COL4A5	23	107850090	Missense_Mutation	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	436242	107850090	47420470	333	2377										
MOSPD1	56180	broad.mit.edu	37	chrX	134033531	134033531	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tctattttggacttttcttaGattcagttaaaaactccaaa	4	7	3	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:134033531G>C	uc004eyb.2	-	2	120	c.-67C>G	c.(-69--65)ATCTA>ATGTA		MOSPD1_uc004eya.2_Translation_Start_Site|MOSPD1_uc010nrv.2_RNA|MOSPD1_uc011mvr.1_Translation_Start_Site	NM_019556	NP_062456	Q9UJG1	MSPD1_HUMAN	motile sperm domain containing 1						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	integral to membrane|nucleus|perinuclear region of cytoplasm	structural molecule activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(192;0.000127)					ACTTTTCTTAGATTCAGTTAA	0.363													0	0	0	0.013537	0	12	10										C	134033531	G	C	134033531	1	2	8	1	0	0	0	0	0	0	0	0	9715	957	33	1		1	MOSPD1	23	134033531	Translation_Start_Site	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	26183441	134033531	21237029	334	2378										
SPANXE	171489	broad.mit.edu	37	chrX	140785779	140785779	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	ccactagtatggtcgaggacTcagatgtttttagttttttc	9	7	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:140785779T>C	uc004fbq.2	-	2	230	c.137A>G	c.(136-138)GAG>GGG	p.E46G		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	SPANX family, member E	46						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					GGTCGAGGACTCAGATGTTTT	0.493													0	0	0	0.001984	0	7	88										C	140785779	T	C	140785779	3	2	8	1	0	0	0	0	1	0	0	0	14989	1551	54	5	160	5	SPANXE	23	140785779	Missense_Mutation	SNP	T	TCGA-BT-A20N-01A-11D-A14W-08	6752248	140785779	14484781	335	2379										
MAGEC3	139081	broad.mit.edu	37	chrX	140969237	140969237	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.22089552238806	74	4.05690024255358e-18	2.95381215469613	3.36510245471711	2.6472844782654	0.877670391918858	0.950809591245429	49	tatacactggatgaaaaggtGgacaagttggtgcagtttct	12	5	1	1			TCGA-BT-A20N-01A-11D-A14W-08	TCGA-BT-A20N-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	341bbffe-7587-4ad0-b3b4-68e64080e216	e6ea3eed-7b54-4b01-bc07-ce26cb941982	g.chrX:140969237G>T	uc011mwp.1	+	4	564	c.564G>T	c.(562-564)GTG>GTT	p.V188V		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	188	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATGAAAAGGTGGACAAGTTGG	0.453													1	0	1.32136e-16	0.00874	1.59352e-16	43	26										T	140969237	G	T	140969237	2	4	8	1	0	0	0	0	0	0	0	1	9182	1335	47	4		4	MAGEC3	23	140969237	Silent	SNP	G	TCGA-BT-A20N-01A-11D-A14W-08	183458	140969237	14301323	336	2380										
SLC35E2	9906	broad.mit.edu	37	chr1	1669760	1669760	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tggggcccagggggcctcacCtgtgtactcccccagaatca	12	15	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:1669760C>A	uc001aib.1	-	4	1002	c.586G>T	c.(586-588)GGA>TGA	p.G196*	SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Missense_Mutation_p.G196W|SLC35E2_uc001ahy.2_Nonsense_Mutation_p.G196*|SLC35E2_uc001ahz.2_Nonsense_Mutation_p.G196*	NM_182838	NP_878258	P0CK97	S35E2_HUMAN	solute carrier family 35, member E2	196						integral to membrane				pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGGGCCTCACCTGTGTACTCC	0.647													1	0	0.000602214	0.014758	0.000630224	4	11										A	1669760	C	A	1669760	4	1	9	1	0	0	0	0	0	1	0	0	14585	695	24	4	1476	4	SLC35E2	1	1669760	Nonsense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		1669760	247580861	1	2381										
CAMTA1	23261	broad.mit.edu	37	chr1	7724195	7724195	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctttaccaccgtcctcaccAaggagatcaagaccgaggac	9	14	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:7724195A>T	uc001aoi.2	+	9	1795	c.1588A>T	c.(1588-1590)AAG>TAG	p.K530*		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CGTCCTCACCAAGGAGATCAA	0.637													0	0	0	0.021553	0	5	59										T	7724195	A	T	7724195	4	4	9	1	0	0	0	0	0	1	0	0	2613	131	5	5	1622	5	CAMTA1	1	7724195	Nonsense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	6054435	7724195	241526426	2	2382										
EIF4G3	8672	broad.mit.edu	37	chr1	21221934	21221934	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aggcaggcatgaactggaagTccagcagaaactccctgtca	11	11	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:21221934T>C	uc001bec.2	-	12	2148	c.1892A>G	c.(1891-1893)GAC>GGC	p.D631G	EIF4G3_uc010odi.1_Missense_Mutation_p.D235G|EIF4G3_uc010odj.1_Missense_Mutation_p.D630G|EIF4G3_uc009vpz.2_Missense_Mutation_p.D351G|EIF4G3_uc001bed.2_Missense_Mutation_p.D631G|EIF4G3_uc001bef.2_Missense_Mutation_p.D630G|EIF4G3_uc001bee.2_Missense_Mutation_p.D637G	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	631					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GAACTGGAAGTCCAGCAGAAA	0.463													0	0	0	0.004482	0	7	72										C	21221934	T	C	21221934	3	2	9	1	0	0	0	0	1	0	0	0	5038	1667	58	5	2949	5	EIF4G3	1	21221934	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	13497739	21221934	228028687	3	2383										
EXTL1	2134	broad.mit.edu	37	chr1	26349162	26349162	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agtcgtggaggagaagaaagTccctgtggctggcactgtca	15	8	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:26349162T>G	uc001blf.2	+	1	892	c.25T>G	c.(25-27)TCC>GCC	p.S9A		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	9	Cytoplasmic (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		GAGAAGAAAGTCCCTGTGGCT	0.667													0	0	0	0.009096	0	4	63										G	26349162	T	G	26349162	3	3	9	1	0	0	0	0	1	0	0	0	5325	1667	58	5	27	5	EXTL1	1	26349162	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	5127228	26349162	222901459	4	2384										
IQCC	55721	broad.mit.edu	37	chr1	32673403	32673403	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aacagtcaggacacaagagtTgggcctctcagaggaccaca	11	11	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:32673403T>A	uc001bum.2	+	5	1168	c.1121T>A	c.(1120-1122)TTG>TAG	p.L374*	IQCC_uc009vua.2_Nonsense_Mutation_p.L454*|IQCC_uc010ogz.1_Nonsense_Mutation_p.L274*|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	374										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACACAAGAGTTGGGCCTCTCA	0.532													0	0	0	0.016723	0	13	120										A	32673403	T	A	32673403	4	1	9	1	0	0	0	0	0	1	0	0	7804	1821	63	5	1379	5	IQCC	1	32673403	Nonsense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	6324241	32673403	216577218	5	2385										
EIF3I	8668	broad.mit.edu	37	chr1	32690056	32690056	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcagctgacaacagctgtcGtctctgggactgtgaaacag	11	11	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:32690056G>C	uc001bur.3	+	5	763	c.230G>C	c.(229-231)CGT>CCT	p.R77P	C1orf91_uc001buo.3_5'Flank|C1orf91_uc001bup.3_5'Flank|C1orf91_uc009vub.1_5'Flank|C1orf91_uc010oha.1_5'Flank|C1orf91_uc001buq.3_5'Flank|EIF3I_uc009vuc.2_Missense_Mutation_p.R77P|EIF3I_uc001bus.2_Missense_Mutation_p.R29P	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	77	WD 2.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				AACAGCTGTCGTCTCTGGGAC	0.473													0	0	0	0.014758	0	4	50										C	32690056	G	C	32690056	3	2	9	1	0	0	0	0	1	0	0	0	5019	1145	40	4	244	4	EIF3I	1	32690056	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	16653	32690056	216560565	6	2386										
MAP7D1	55700	broad.mit.edu	37	chr1	36636690	36636690	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccggacacccctcctgccatGaagaatgccactagctctaa	7	16	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:36636690G>T	uc001bzz.2	+	2	381	c.165G>T	c.(163-165)ATG>ATT	p.M55I	MAP7D1_uc001caa.2_Missense_Mutation_p.M55I|MAP7D1_uc001cab.2_Missense_Mutation_p.M55I|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	55	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CTCCTGCCATGAAGAATGCCA	0.652													1	0	2.74318e-10	0.006214	3.12514e-10	9	88										T	36636690	G	T	36636690	3	4	9	1	0	0	0	0	1	0	0	0	9267	1290	45	3	171	3	MAP7D1	1	36636690	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	3946634	36636690	212613931	7	2387										
KTI12	112970	broad.mit.edu	37	chr1	52499087	52499087	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcgcgcccgccacctgaggtCccgcgatcgggccgccgggc	15	19	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:52499087C>T	uc001ctj.1	-	1	386	c.347G>A	c.(346-348)GGA>GAA	p.G116E	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	116							ATP binding			central_nervous_system(2)	2						CACCTGAGGTCCCGCGATCGG	0.701													0	0	0	0.021553	0	5	65										T	52499087	C	T	52499087	3	4	9	1	0	0	0	0	1	0	0	0	8584	855	30	1	721	1	KTI12	1	52499087	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	15862397	52499087	196751534	8	2388										
SCP2	6342	broad.mit.edu	37	chr1	53504595	53504595	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atttttctttccaggaagggGaacagtttgtgaagaaaatc	10	5	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:53504595G>A	uc001cur.1	+	14	1466	c.1345G>A	c.(1345-1347)GAA>AAA	p.E449K	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_Missense_Mutation_p.E368K|SCP2_uc010onp.1_Missense_Mutation_p.E425K|SCP2_uc009vzi.1_Missense_Mutation_p.E405K|SCP2_uc010onq.1_Missense_Mutation_p.E45K|SCP2_uc001cut.1_Missense_Mutation_p.E42K|SCP2_uc001cuu.1_Intron	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	449	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						CCAGGAAGGGGAACAGTTTGT	0.423													0	0	0	0.010729	0	10	110										A	53504595	G	A	53504595	3	1	9	1	0	0	0	0	1	0	0	0	13934	1175	41	1	1423	1	SCP2	1	53504595	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1005508	53504595	195746026	9	2389										
C1orf146	388649	broad.mit.edu	37	chr1	92709803	92709803	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttttattaatggatactaagGaatgtcttctgtcaactgaa	7	5	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:92709803G>A	uc001doq.2	+	4	262	c.190G>A	c.(190-192)GAA>AAA	p.E64K	C1orf146_uc010ote.1_Missense_Mutation_p.E5K	NM_001012425	NP_001012425	Q5VVC0	CA146_HUMAN	hypothetical protein LOC388649	64										ovary(1)	1		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		GGATACTAAGGAATGTCTTCT	0.299													0	0	0	0.021553	0	6	42										A	92709803	G	A	92709803	3	1	9	1	0	0	0	0	1	0	0	0	2003	1175	41	1	200	1	C1orf146	1	92709803	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	39205208	92709803	156540818	10	2390										
NTNG1	22854	broad.mit.edu	37	chr1	107937933	107937933	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cctatctccccatccccaaaGgcactgcaaatacctgtgag	6	16	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:107937933G>C	uc001dvh.3	+	4	1763	c.1045G>C	c.(1045-1047)GGC>CGC	p.G349R	NTNG1_uc001dvf.3_Missense_Mutation_p.G349R|NTNG1_uc010out.1_Missense_Mutation_p.G349R|NTNG1_uc001dvc.3_Missense_Mutation_p.G349R|NTNG1_uc001dvi.2_5'UTR|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_Missense_Mutation_p.R21T|NTNG1_uc001dvd.1_Missense_Mutation_p.G349R	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	349	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CATCCCCAAAGGCACTGCAAA	0.453													0	0	0	0.02938	0	6	94										C	107937933	G	C	107937933	3	2	9	1	0	0	0	0	1	0	0	0	10704	1000	35	4	1055	4	NTNG1	1	107937933	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	15228130	107937933	141312688	11	2391										
STXBP3	6814	broad.mit.edu	37	chr1	109342863	109342863	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atgctattgataatagattaGattcaaaagaatggccatat	7	4	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:109342863G>A	uc001dvy.2	+	17	1546	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	491					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		TAATAGATTAGATTCAAAAGA	0.338													0	0	0	0.004482	0	9	42										A	109342863	G	A	109342863	3	1	9	1	0	0	0	0	1	0	0	0	15353	942	33	1	1537	1	STXBP3	1	109342863	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1404930	109342863	139907758	12	2392										
MAGI3	260425	broad.mit.edu	37	chr1	114201796	114201796	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	catatctctgcagtgaatggGcagtccattgttgaactgtc	10	9	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:114201796G>C	uc001edk.2	+	16	2905	c.2724G>C	c.(2722-2724)GGG>GGC	p.G908G	MAGI3_uc001edh.3_Silent_p.G933G|MAGI3_uc001edi.3_Silent_p.G908G|MAGI3_uc010owm.1_Silent_p.G933G|MAGI3_uc001edj.2_Silent_p.G629G	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	933	Interaction with LPAR2 and GRIN2B.|PDZ 5.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGTGAATGGGCAGTCCATTG	0.453													0	0	0	0.008291	0	11	93										C	114201796	G	C	114201796	2	2	9	1	0	0	0	0	0	0	0	1	9192	1190	42	4		4	MAGI3	1	114201796	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	4858933	114201796	135048825	13	2393										
SLC22A15	55356	broad.mit.edu	37	chr1	116569600	116569600	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctcctggaggaccctagccAttctggttaacctgcaggga	12	12	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:116569600A>G	uc001egb.3	+	5	815	c.685A>G	c.(685-687)ATT>GTT	p.I229V	SLC22A15_uc001ega.2_Missense_Mutation_p.I229V	NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	229	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GACCCTAGCCATTCTGGTTAA	0.433													0	0	0	0.00308	0	8	105										G	116569600	A	G	116569600	3	3	9	1	0	0	0	0	1	0	0	0	14446	217	8	5	703	5	SLC22A15	1	116569600	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	2367804	116569600	132681021	14	2394										
GATAD2B	57459	broad.mit.edu	37	chr1	153792155	153792155	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aacggggactggaagcctcaTtgtcagacaaaacaatgatg	11	8	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:153792155T>C	uc001fdb.3	-	3	636	c.392A>G	c.(391-393)AAT>AGT	p.N131S		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	131						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGAAGCCTCATTGTCAGACAA	0.398													0	0	0	0.020292	0	13	90										C	153792155	T	C	153792155	3	2	9	1	0	0	0	0	1	0	0	0	6261	1493	52	5	1425	5	GATAD2B	1	153792155	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	37222555	153792155	95458466	15	2395										
ASH1L	55870	broad.mit.edu	37	chr1	155449667	155449667	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaacttgaaagaatctgattCaacagtttctttctctttaa	5	7	4	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:155449667C>G	uc009wqq.2	-	3	3474	c.2994G>C	c.(2992-2994)TTG>TTC	p.L998F	ASH1L_uc001fkt.2_Missense_Mutation_p.L998F|ASH1L_uc009wqr.1_Missense_Mutation_p.L998F	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	998					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GAATCTGATTCAACAGTTTCT	0.313													0	0	0	0.014758	0	5	75										G	155449667	C	G	155449667	3	3	9	1	0	0	0	0	1	0	0	0	1041	825	29	1	6004	1	ASH1L	1	155449667	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1657512	155449667	93800954	16	2396										
APOA1BP	128240	broad.mit.edu	37	chr1	156563828	156563828	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctggagaagaagtaccagctGaacctgccaccctaccctga	9	14	0	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:156563828G>A	uc001fph.2	+	6	858	c.819G>A	c.(817-819)CTG>CTA	p.L273L	APOA1BP_uc001fpg.2_3'UTR|APOA1BP_uc001fpi.2_Missense_Mutation_p.E255K|APOA1BP_uc001fpj.2_Silent_p.L190L|APOA1BP_uc001fpk.2_Silent_p.L170L|APOA1BP_uc010php.1_Silent_p.L170L	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	273	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGTACCAGCTGAACCTGCCAC	0.547													0	0	0	0.008291	0	7	106										A	156563828	G	A	156563828	2	1	9	1	0	0	0	0	0	0	0	1	781	1277	45	1		1	APOA1BP	1	156563828	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1114161	156563828	92686793	17	2397										
ARHGAP30	257106	broad.mit.edu	37	chr1	161018826	161018826	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcctgcctccaggctcagccTgcttgtcctccccaacttcc	7	20	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:161018826T>C	uc001fxl.2	-	12	2331	c.1985A>G	c.(1984-1986)CAG>CGG	p.Q662R	ARHGAP30_uc001fxk.2_Missense_Mutation_p.Q662R|ARHGAP30_uc001fxm.2_Missense_Mutation_p.Q508R|ARHGAP30_uc009wtx.2_Missense_Mutation_p.Q335R|ARHGAP30_uc001fxn.1_Missense_Mutation_p.Q508R	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	662	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGGCTCAGCCTGCTTGTCCTC	0.617													0	0	0	0.024334	0	26	145										C	161018826	T	C	161018826	3	2	9	1	0	0	0	0	1	0	0	0	879	1580	55	5	1324	5	ARHGAP30	1	161018826	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	4454998	161018826	88231795	18	2398										
FMO4	2329	broad.mit.edu	37	chr1	171303803	171303803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aagtctttcccttaaacctaGagagagcgacattagccatc	7	11	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:171303803G>C	uc001gho.2	+	8	1298	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	361					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTTAAACCTAGAGAGAGCGAC	0.403													0	0	0	0.008291	0	10	92										C	171303803	G	C	171303803	3	2	9	1	0	0	0	0	1	0	0	0	5957	943	33	1	1103	1	FMO4	1	171303803	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	10284977	171303803	77946818	19	2399										
TPR	7175	broad.mit.edu	37	chr1	186329966	186329966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctccaatctccctattttctCaagcatttctttttccattt	1	13	3	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:186329966C>G	uc001grv.2	-	10	1327	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q	TPR_uc010pop.1_Missense_Mutation_p.E420Q	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	344	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CCTATTTTCTCAAGCATTTCT	0.348			T	NTRK1	papillary thyroid								0	0	0	0.004672	0	3	51										G	186329966	C	G	186329966	3	3	9	1	0	0	0	0	1	0	0	0	16413	835	29	1	6229	1	TPR	1	186329966	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	15026163	186329966	62920655	20	2400										
TPR	7175	broad.mit.edu	37	chr1	186330823	186330823	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tagttcattgctctttgcttCtgagtcatcagcggcactct	8	11	6	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:186330823C>G	uc001grv.2	-	9	1186	c.889G>C	c.(889-891)GAA>CAA	p.E297Q	TPR_uc010pop.1_Missense_Mutation_p.E373Q	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	297	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CTCTTTGCTTCTGAGTCATCA	0.373			T	NTRK1	papillary thyroid								0	0	0	0.00308	0	7	78										G	186330823	C	G	186330823	3	3	9	1	0	0	0	0	1	0	0	0	16413	922	32	1	6374	1	TPR	1	186330823	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	857	186330823	62919798	21	2401										
MYBPH	4608	broad.mit.edu	37	chr1	203139485	203139485	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctgagtccacacaggttttCtgagaagacccggaaggagt	13	9	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:203139485C>T	uc001gzh.1	-	7	1086	c.1027G>A	c.(1027-1029)GAA>AAA	p.E343K	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	343	Fibronectin type-III 2.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		CACAGGTTTTCTGAGAAGACC	0.597													0	0	0	0.004672	0	3	48										T	203139485	C	T	203139485	3	4	9	1	0	0	0	0	1	0	0	0	10014	922	32	1	422	1	MYBPH	1	203139485	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	16808662	203139485	46111136	22	2402										
LAX1	54900	broad.mit.edu	37	chr1	203743363	203743363	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgtattctccaggagctgagGacagtgattcactcagcaat	10	9	3	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:203743363G>A	uc001haa.2	+	5	1161	c.751G>A	c.(751-753)GAC>AAC	p.D251N	LAX1_uc010pql.1_Missense_Mutation_p.D235N|LAX1_uc001hab.2_Missense_Mutation_p.D175N	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	251	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGGAGCTGAGGACAGTGATTC	0.488													0	0	0	0.021553	0	5	40										A	203743363	G	A	203743363	3	1	9	1	0	0	0	0	1	0	0	0	8648	1174	41	1	814	1	LAX1	1	203743363	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	603878	203743363	45507258	23	2403										
SLC26A9	115019	broad.mit.edu	37	chr1	205902176	205902177	+	Missense_Mutation	DNP	CC	CC	AT													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caggagagcacaggcagcagCccaaacaccacagctttgat							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:205902176_205902177CC>AT	uc001hdq.2	-	3	275_276	c.161_162GG>AT	c.(160-162)GGG>GAT	p.G54D	SLC26A9_uc001hdp.2_Missense_Mutation_p.G54D	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	54	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CAGGCAGCAGCCCAAACACCAC	0.55													0	0	0	0.004672	0	6	42										AT	205902177	CC	AT	205902176	3	1	9	1	0	0	0	0	1	0	0	0	14524	726	26	4	2585	4	SLC26A9	1	205902176	Missense_Mutation	DNP	CC	TCGA-BT-A20O-01A-21D-A14W-08	2158813	205902176	43348445	24	2404										
CABC1	56997	broad.mit.edu	37	chr1	227174193	227174193	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tggatgccatcctcatcctgGgggaggccttcgcctctgat	12	13	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:227174193G>T	uc001hqm.1	+	20	5118	c.1699G>T	c.(1699-1701)GGG>TGG	p.G567W	CABC1_uc001hqn.1_Missense_Mutation_p.G567W|CABC1_uc009xeq.1_Missense_Mutation_p.G515W|CABC1_uc010pvq.1_Missense_Mutation_p.G288W|CABC1_uc010pvr.1_Missense_Mutation_p.G241W|CABC1_uc001hqo.1_Missense_Mutation_p.G288W|CABC1_uc009xer.1_Missense_Mutation_p.G83W	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	567					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CCTCATCCTGGGGGAGGCCTT	0.587													1	0	0.000157383	0.00308	0.000167958	8	56										T	227174193	G	T	227174193	3	4	9	1	0	0	0	0	1	0	0	0	2527	1232	43	4	1753	4	CABC1	1	227174193	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	21272017	227174193	22076428	25	2405										
CDC42BPA	8476	broad.mit.edu	37	chr1	227227863	227227863	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cagccctgtcttattaaaccCaccatcaaggaggtacactg	7	13	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:227227863C>G	uc001hqr.2	-	23	4006	c.3063G>C	c.(3061-3063)GTG>GTC	p.V1021V	CDC42BPA_uc001hqq.2_Silent_p.V320V|CDC42BPA_uc001hqs.2_Silent_p.V940V|CDC42BPA_uc009xes.2_Silent_p.V993V|CDC42BPA_uc010pvs.1_Silent_p.V1001V|CDC42BPA_uc001hqp.2_Silent_p.V177V|CDC42BPA_uc001hqu.1_Silent_p.V228V	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1034	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TTATTAAACCCACCATCAAGG	0.343													0	0	0	0.004482	0	8	58										G	227227863	C	G	227227863	2	3	9	1	0	0	0	0	0	0	0	1	3072	581	21	4		4	CDC42BPA	1	227227863	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	53670	227227863	22022758	26	2406										
LYST	1130	broad.mit.edu	37	chr1	235972029	235972029	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttcttcaaaaacaaagttctGataagcctttaaagcatccc	4	10	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:235972029G>A	uc001hxj.2	-	5	2264	c.2089C>T	c.(2089-2091)CAG>TAG	p.Q697*	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Nonsense_Mutation_p.Q697*	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	697	WD 1.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACAAAGTTCTGATAAGCCTTT	0.368									Chediak-Higashi_syndrome				0	0	0	0.021553	0	6	52										A	235972029	G	A	235972029	4	1	9	1	0	0	0	0	0	1	0	0	9128	1299	45	1	9512	1	LYST	1	235972029	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	8744166	235972029	13278592	27	2407										
RYR2	6262	broad.mit.edu	37	chr1	237756804	237756804	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcagtgagaatctttcctgGacaagaacctgctaatgtct	8	10	3	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:237756804G>A	uc001hyl.1	+	33	4424	c.4304G>A	c.(4303-4305)GGA>GAA	p.G1435E		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1435	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCTTTCCTGGACAAGAACCT	0.393													0	0	0	0.02938	0	6	49										A	237756804	G	A	237756804	3	1	9	1	0	0	0	0	1	0	0	0	13769	1174	41	1	4434	1	RYR2	1	237756804	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1784775	237756804	11493817	28	2408										
AHCTF1	25909	broad.mit.edu	37	chr1	247053295	247053295	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aacgctcaaacttctgtcgaCgactggtgtagtagttctga	10	9	3	1	rs140782802	byFrequency	TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr1:247053295C>T	uc001ibu.1	-	16	2124	c.2117G>A	c.(2116-2118)CGT>CAT	p.R706H	AHCTF1_uc001ibv.1_Missense_Mutation_p.R715H|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	706	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTCTGTCGACGACTGGTGTA	0.343													0	0	0	0.014323	0	21	113										T	247053295	C	T	247053295	3	4	9	1	0	0	0	0	1	0	0	0	408	536	19	2	4763	2	AHCTF1	1	247053295	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	9296491	247053295	2197326	29	2409										
APOB	338	broad.mit.edu	37	chr2	21228278	21228278	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaagcgtgaactgggacacaGttaactgagattcaggcacg	13	8	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:21228278G>C	uc002red.2	-	26	11590	c.11462C>G	c.(11461-11463)ACT>AGT	p.T3821S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3821					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGGACACAGTTAACTGAGA	0.423													0	0	0	0.014758	0	4	167										C	21228278	G	C	21228278	3	2	9	1	0	0	0	0	1	0	0	0	785	1029	36	4	2245	4	APOB	2	21228278	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		21228278	221971095	30	2410										
APOB	338	broad.mit.edu	37	chr2	21249677	21249677	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cacctgctcatgtttatcatCtttggtatagccaaagtggt	8	9	3	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:21249677C>T	uc002red.2	-	15	2355	c.2227G>A	c.(2227-2229)GAT>AAT	p.D743N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	743					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTTTATCATCTTTGGTATAG	0.393													0	0	0	0.02938	0	7	93										T	21249677	C	T	21249677	3	4	9	1	0	0	0	0	1	0	0	0	785	913	32	1	11524	1	APOB	2	21249677	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	21399	21249677	221949696	31	2411										
CAPN13	92291	broad.mit.edu	37	chr2	30974059	30974059	+	Frame_Shift_Del	DEL	G	G	-													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtgacgcacacgacaacattGgtgccttccattggctcttg							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:30974059delG	uc002rnn.2	-	11	1322	c.1146delC	c.(1144-1146)ACCfs	p.T382fs	CAPN13_uc002rnp.1_Frame_Shift_Del_p.T382fs	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	382					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CGACAACATTGGTGCCTTCCA	0.468																		8	46	---	---								-	30974059	G	-	30974059	7	5	9	1	0	1	0	1	0	0	0	0	2626	1335	47	0	911	0	CAPN13	2	30974059	Frame_Shift_Del	DEL	G	TCGA-BT-A20O-01A-21D-A14W-08	9724382	30974059	212225314	32	2412										
DARS	1615	broad.mit.edu	37	chr2	136673932	136673932	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tttattcactgtttgaatttCagtctgaaacctatttgcag	6	7	3	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:136673932C>T	uc002tux.1	-	11	1154	c.970G>A	c.(970-972)GAA>AAA	p.E324K	DARS_uc010fnj.1_Missense_Mutation_p.E224K	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	324					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GTTTGAATTTCAGTCTGAAAC	0.348													0	0	0	0.00308	0	7	87										T	136673932	C	T	136673932	3	4	9	1	0	0	0	0	1	0	0	0	4241	835	29	1	559	1	DARS	2	136673932	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	105699873	136673932	106525441	33	2413										
THSD7B	80731	broad.mit.edu	37	chr2	138320875	138320875	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cttcatgcaaaatcaacaatGagctgaggtccctgcgctgt	9	11	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:138320875G>C	uc002tva.1	+	15	3136	c.3136G>C	c.(3136-3138)GAG>CAG	p.E1046Q	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATCAACAATGAGCTGAGGTC	0.453													0	0	0	0.009096	0	4	24										C	138320875	G	C	138320875	3	2	9	1	0	0	0	0	1	0	0	0	15877	1291	45	1	3193	1	THSD7B	2	138320875	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1646943	138320875	104878498	34	2414										
ZEB2	9839	broad.mit.edu	37	chr2	145147516	145147516	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgatagggcttctcgcccgaGtgaagccttgagtgctcgat	13	10	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:145147516G>A	uc002tvu.2	-	10	3627	c.3147C>T	c.(3145-3147)CAC>CAT	p.H1049H	ZEB2_uc002tvv.2_Silent_p.H1043H|ZEB2_uc010zbm.1_Silent_p.H1020H|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1049	C2H2-type 6.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCTCGCCCGAGTGAAGCCTTG	0.478													0	0	0	0.00308	0	8	49										A	145147516	G	A	145147516	2	1	9	1	0	0	0	0	0	0	0	1	17621	1020	36	2		2	ZEB2	2	145147516	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	6826641	145147516	98051857	35	2415										
KCNH7	90134	broad.mit.edu	37	chr2	163236421	163236421	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cacttccccgtaggtgaggtCgctttcggtttcagagatac	11	11	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:163236421C>G	uc002uch.1	-	14	3285	c.3073G>C	c.(3073-3075)GAC>CAC	p.D1025H		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1025	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TAGGTGAGGTCGCTTTCGGTT	0.517													0	0	0	0.013537	0	12	154										G	163236421	C	G	163236421	3	3	9	1	0	0	0	0	1	0	0	0	8037	884	31	1	529	1	KCNH7	2	163236421	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	18088905	163236421	79962952	36	2416										
LRP2	4036	broad.mit.edu	37	chr2	170009322	170009322	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aatttaccttccaacccagtCcactgctattccatctggct	4	15	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:170009322C>A	uc002ues.2	-	67	12661	c.12448G>T	c.(12448-12450)GAC>TAC	p.D4150Y		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4150	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCAACCCAGTCCACTGCTATT	0.478													1	0	0.00010058	0.013537	0.000108194	13	137										A	170009322	C	A	170009322	3	1	9	1	0	0	0	0	1	0	0	0	8956	855	30	3	1571	3	LRP2	2	170009322	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	6772901	170009322	73190051	37	2417										
HNRNPA3	220988	broad.mit.edu	37	chr2	178082493	178082493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gggctatggtggtggtggacCaggatatggaaaccaaggtg	18	5	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:178082493C>T	uc002ulb.1	+	8	987	c.881C>T	c.(880-882)CCA>CTA	p.P294L	HNRNPA3_uc002ulc.1_Missense_Mutation_p.P294L|HNRNPA3_uc002uld.2_Missense_Mutation_p.P272L|HNRNPA3_uc002ule.2_Missense_Mutation_p.P71L	NM_194247	NP_919223	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3	294	Gly-rich.					catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(2)	2						GGTGGTGGACCAGGATATGGA	0.438													0	0	0	0.006214	0	10	120										T	178082493	C	T	178082493	3	4	9	1	0	0	0	0	1	0	0	0	7260	594	21	2	911	2	HNRNPA3	2	178082493	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	8073171	178082493	65116880	38	2418										
CASP8	841	broad.mit.edu	37	chr2	202131238	202131238	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cagcagaaatctttatgataTtggggaacaactggacagtg	11	6	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:202131238T>C	uc002uxr.1	+	3	238	c.29T>C	c.(28-30)ATT>ACT	p.I10T	CASP8_uc010ftc.1_Missense_Mutation_p.I10T|CASP8_uc002uxo.1_Missense_Mutation_p.I10T|CASP8_uc002uxp.1_Missense_Mutation_p.I10T|CASP8_uc002uxq.1_Missense_Mutation_p.I10T|CASP8_uc002uxs.1_Missense_Mutation_p.I10T|CASP8_uc002uxt.1_Missense_Mutation_p.I69T|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Missense_Mutation_p.I10T|CASP8_uc002uxw.1_Missense_Mutation_p.I10T|CASP8_uc002uxy.1_Missense_Mutation_p.I10T|CASP8_uc002uxx.1_Missense_Mutation_p.I10T|CASP8_uc010ftf.2_Missense_Mutation_p.I10T	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	10	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						CTTTATGATATTGGGGAACAA	0.408										HNSCC(4;0.00038)			0	0	0	0.02938	0	6	60										C	202131238	T	C	202131238	3	2	9	1	0	0	0	0	1	0	0	0	2677	1493	52	5	212	5	CASP8	2	202131238	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	24048745	202131238	41068135	39	2419										
SCLY	51540	broad.mit.edu	37	chr2	238999877	238999877	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aggacagagaacaccccaatGattgctggccttgggaaggt	13	9	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr2:238999877G>A	uc010fyv.2	+	8	967	c.903G>A	c.(901-903)ATG>ATA	p.M301I	SCLY_uc002vxm.3_Missense_Mutation_p.M268I|SCLY_uc002vxn.2_Missense_Mutation_p.M301I|SCLY_uc010znq.1_Intron|SCLY_uc010znr.1_Missense_Mutation_p.M207I	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	301					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		ACACCCCAATGATTGCTGGCC	0.463													0	0	0	0.024245	0	10	111										A	238999877	G	A	238999877	3	1	9	1	0	0	0	0	1	0	0	0	13907	1290	45	1	933	1	SCLY	2	238999877	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	36868639	238999877	4199496	40	2420										
ATP2B2	491	broad.mit.edu	37	chr3	10370803	10370803	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctacggaacgccttcacgaCgcggatctgcaagggaagca	13	12	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:10370803C>T	uc003bvt.2	-	23	3866	c.3427G>A	c.(3427-3429)GTC>ATC	p.V1143I	ATP2B2_uc003bvv.2_Missense_Mutation_p.V1098I|ATP2B2_uc003bvw.2_Missense_Mutation_p.V1098I|ATP2B2_uc003bvs.2_RNA|ATP2B2_uc010hdo.2_Missense_Mutation_p.V848I|hsa-mir-378b|MI0014154_5'Flank	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1143	Calmodulin-binding subdomain B (By similarity).|Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GCCTTCACGACGCGGATCTGC	0.582													0	0	0	0.009096	0	4	57										T	10370803	C	T	10370803	3	4	9	1	0	0	0	0	1	0	0	0	1140	536	19	2	308	2	ATP2B2	3	10370803	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		10370803	187651627	41	2421										
TRIM71	131405	broad.mit.edu	37	chr3	32927521	32927521	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gccgtgacggcgaggcataaGaaagccctggaggaacgcga	16	10	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:32927521G>A	uc003cff.2	+	3	1179	c.1116G>A	c.(1114-1116)AAG>AAA	p.K372K		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	372					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CGAGGCATAAGAAAGCCCTGG	0.617													0	0	0	0.014758	0	5	39										A	32927521	G	A	32927521	2	1	9	1	0	0	0	0	0	0	0	1	16541	933	33	1		1	TRIM71	3	32927521	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	22556718	32927521	165094909	42	2422										
SLC22A13	9390	broad.mit.edu	37	chr3	38318947	38318947	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtggcctttgtgagcagcacAtacttctgattgaggtctct	11	9	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:38318947A>G	uc003chz.3	+	10	1701	c.1647A>G	c.(1645-1647)ACA>ACG	p.T549T		NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	549	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		TGAGCAGCACATACTTCTGAT	0.562													0	0	0	0.021553	0	6	67										G	38318947	A	G	38318947	2	3	9	1	0	0	0	0	0	0	0	1	14444	204	8	5		5	SLC22A13	3	38318947	Silent	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	5391426	38318947	159703483	43	2423										
CCDC36	339834	broad.mit.edu	37	chr3	49294677	49294677	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caggaaagaatttgctctatGacctgggttttgatagcagt	11	6	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:49294677G>A	uc003cwk.2	+	10	2134	c.1747G>A	c.(1747-1749)GAC>AAC	p.D583N	CCDC36_uc011bck.1_Missense_Mutation_p.D583N	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	583										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TTTGCTCTATGACCTGGGTTT	0.488													0	0	0	0.013537	0	13	118										A	49294677	G	A	49294677	3	1	9	1	0	0	0	0	1	0	0	0	2808	1290	45	1	1773	1	CCDC36	3	49294677	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	10975730	49294677	148727753	44	2424										
HSPBAP1	79663	broad.mit.edu	37	chr3	122459659	122459659	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcagatgttctgcagcgatCaaaaaatgcagaaacagctg	9	9	3	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:122459659C>T	uc003efu.1	-	8	1123	c.1000G>A	c.(1000-1002)GAT>AAT	p.D334N	HSPBAP1_uc003eft.1_Missense_Mutation_p.D45N	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	334						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		CTGCAGCGATCAAAAAATGCA	0.403													0	0	0	0.013537	0	11	131										T	122459659	C	T	122459659	3	4	9	1	0	0	0	0	1	0	0	0	7425	826	29	1	470	1	HSPBAP1	3	122459659	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	73164982	122459659	75562771	45	2425										
KCNAB1	7881	broad.mit.edu	37	chr3	156234066	156234066	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttttcttctgtaggtgttggCgcaatgacatggtctccact	10	9	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:156234066C>T	uc003far.2	+	11	937	c.873C>T	c.(871-873)GGC>GGT	p.G291G	KCNAB1_uc011bon.1_Silent_p.G262G|KCNAB1_uc003fas.2_Silent_p.G280G|KCNAB1_uc003fat.2_Silent_p.G273G|KCNAB1_uc010hvt.1_Silent_p.G244G|KCNAB1_uc011boo.1_Silent_p.G167G	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related	291						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TAGGTGTTGGCGCAATGACAT	0.453													0	0	0	0.014758	0	5	45										T	156234066	C	T	156234066	2	4	9	1	0	0	0	0	0	0	0	1	8009	755	27	2		2	KCNAB1	3	156234066	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	33774407	156234066	41788364	46	2426										
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.00308	0	6	38										A	178936082	G	A	178936082	3	1	9	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1658	1	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	22702016	178936082	19086348	47	2427										
NOP14	8602	broad.mit.edu	37	chr4	2950082	2950082	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctccaccaccaaaagctgctCttccatcgatcttcctaaca	3	17	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:2950082C>G	uc003ggj.1	-	9	1408	c.1336G>C	c.(1336-1338)GAG>CAG	p.E446Q	C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.E192Q|NOP14_uc003ggk.3_Missense_Mutation_p.E446Q|NOP14_uc003ggl.2_Missense_Mutation_p.E446Q	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	446					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						AAAAGCTGCTCTTCCATCGAT	0.413													0	0	0	0.006214	0	10	88										G	2950082	C	G	2950082	3	3	9	1	0	0	0	0	1	0	0	0	10536	922	32	1	1277	1	NOP14	4	2950082	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		2950082	188204194	48	2428										
UGDH	7358	broad.mit.edu	37	chr4	39523129	39523129	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acagatcttcttaatttcaaAcatgattgtactagaaggaa	6	6	3	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:39523129A>G	uc003guk.1	-	2	320	c.4T>C	c.(4-6)TTT>CTT	p.F2L	UGDH_uc011byp.1_Intron|UGDH_uc003gul.1_Missense_Mutation_p.F2L	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	2					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TTAATTTCAAACATGATTGTA	0.333													0	0	0	0.004672	0	3	58										G	39523129	A	G	39523129	3	3	9	1	0	0	0	0	1	0	0	0	16937	43	2	5	1524	5	UGDH	4	39523129	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	36573047	39523129	151631147	49	2429										
SLC30A9	10463	broad.mit.edu	37	chr4	42069148	42069148	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aatgtgatattattggaggaTactgctgcagtcttgggagt	13	4	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:42069148T>C	uc003gwl.2	+	14	1337	c.1191T>C	c.(1189-1191)GAT>GAC	p.D397D	SLC30A9_uc011byx.1_Silent_p.D157D	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	397	Helical; (Potential).				nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						TATTGGAGGATACTGCTGCAG	0.353													0	0	0	0.021553	0	5	110										C	42069148	T	C	42069148	2	2	9	1	0	0	0	0	0	0	0	1	14562	1403	49	5		5	SLC30A9	4	42069148	Silent	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	2546019	42069148	149085128	50	2430										
UGT2B10	7365	broad.mit.edu	37	chr4	69692212	69692212	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggataccccagaatgaccttCtaggtaacactctggtgaac	9	11	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:69692212C>T	uc003hee.2	+	4	1109	c.1084C>T	c.(1084-1086)CTA>TTA	p.L362L	UGT2B10_uc011cam.1_Silent_p.L278L	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	362					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GAATGACCTTCTAGGTAACAC	0.378													0	0	0	0.021553	0	5	63										T	69692212	C	T	69692212	2	4	9	1	0	0	0	0	0	0	0	1	16953	912	32	1		1	UGT2B10	4	69692212	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	27623064	69692212	121462064	51	2431										
HSD17B13	345275	broad.mit.edu	37	chr4	88239530	88239530	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgttgctgcagtctaccacaTacgcatgcgcagtgacgcct	10	13	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:88239530T>C	uc003hqo.2	-	2	332	c.269A>G	c.(268-270)TAT>TGT	p.Y90C	HSD17B13_uc010ikk.2_Intron	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	90						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		GTCTACCACATACGCATGCGC	0.458													0	0	0	0.021553	0	6	62										C	88239530	T	C	88239530	3	2	9	1	0	0	0	0	1	0	0	0	7382	1406	49	5	657	5	HSD17B13	4	88239530	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	18547318	88239530	102914746	52	2432										
C4orf21	55345	broad.mit.edu	37	chr4	113468478	113468478	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caaaaagagtttgttccaatCcattttcatgagctgcatca	6	9	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:113468478C>G	uc003iau.2	-	24	5772	c.5561G>C	c.(5560-5562)GGA>GCA	p.G1854A	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.G312A	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	676						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTGTTCCAATCCATTTTCATG	0.373													0	0	0	0.004672	0	3	31										G	113468478	C	G	113468478	3	3	9	1	0	0	0	0	1	0	0	0	2254	855	30	1	773	1	C4orf21	4	113468478	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	25228948	113468478	77685798	53	2433										
SH3D19	152503	broad.mit.edu	37	chr4	152065152	152065152	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtgtcttctcccttttggcaCtccaagtaattattttccgt	6	11	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:152065152C>G	uc010ipl.1	-	13	2452	c.1362G>C	c.(1360-1362)GAG>GAC	p.E454D	SH3D19_uc003imb.2_Missense_Mutation_p.E209D|SH3D19_uc003imc.2_Missense_Mutation_p.E395D|SH3D19_uc003ime.2_Missense_Mutation_p.E431D|SH3D19_uc010ipm.2_Missense_Mutation_p.E431D	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	454	SH3 1.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				CCTTTTGGCACTCCAAGTAAT	0.398													0	0	0	0.009096	0	4	55										G	152065152	C	G	152065152	3	3	9	1	0	0	0	0	1	0	0	0	14249	564	20	4	1046	4	SH3D19	4	152065152	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	38596674	152065152	39089124	54	2434										
FBXW7	55294	broad.mit.edu	37	chr4	153247366	153247366	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aaaccctaagagtggcatctCgagaaccgctaacaactctg	8	12	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:153247366C>G	uc003ims.2	-	10	1585	c.1436G>C	c.(1435-1437)CGA>CCA	p.R479P	FBXW7_uc011cii.1_Missense_Mutation_p.R479P|FBXW7_uc003imt.2_Missense_Mutation_p.R479P|FBXW7_uc011cih.1_Missense_Mutation_p.R303P|FBXW7_uc003imq.2_Missense_Mutation_p.R399P|FBXW7_uc003imr.2_Missense_Mutation_p.R361P	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	479	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R479Q(31)|p.R479L(7)|p.R479G(3)|p.R399Q(2)|p.R240L(1)|p.R399L(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.014758	0	5	59										G	153247366	C	G	153247366	3	3	9	1	0	0	0	0	1	0	0	0	5769	884	31	1	699	1	FBXW7	4	153247366	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1182214	153247366	37906910	55	2435										
GUCY1B3	2983	broad.mit.edu	37	chr4	156715077	156715077	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aagaaaaagagtcaaaagaaGaggatttttatgaagatctt	9	2	2	6			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:156715077G>C	uc003ipc.2	+	6	732	c.565G>C	c.(565-567)GAG>CAG	p.E189Q	GUCY1B3_uc011cio.1_Missense_Mutation_p.E211Q|GUCY1B3_uc011cip.1_Missense_Mutation_p.E169Q|GUCY1B3_uc003ipd.2_Missense_Mutation_p.E117Q|GUCY1B3_uc010iqf.2_Missense_Mutation_p.E189Q|GUCY1B3_uc010iqg.2_Missense_Mutation_p.E117Q|GUCY1B3_uc011ciq.1_Missense_Mutation_p.E117Q	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	189					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		GTCAAAAGAAGAGGATTTTTA	0.333													0	0	0	0.014758	0	5	53										C	156715077	G	C	156715077	3	2	9	1	0	0	0	0	1	0	0	0	6895	943	33	1	587	1	GUCY1B3	4	156715077	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	3467711	156715077	34439199	56	2436										
FAT1	2195	broad.mit.edu	37	chr4	187541654	187541654	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cagtggttgacagaactcctGaagtgcggcttattttaaat	10	7	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr4:187541654G>T	uc003izf.2	-	10	6274	c.6086C>A	c.(6085-6087)TCA>TAA	p.S2029*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2029	Extracellular (Potential).|Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CAGAACTCCTGAAGTGCGGCT	0.463										HNSCC(5;0.00058)			1	0	9.57634e-11	0.01892	1.0956e-10	23	219										T	187541654	G	T	187541654	4	4	9	1	0	0	0	0	0	1	0	0	5689	1294	45	3	7752	3	FAT1	4	187541654	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	30826577	187541654	3612622	57	2437										
ADAMTS12	81792	broad.mit.edu	37	chr5	33624410	33624410	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcccaggcacacaccgcagCgatcctcggtggcattggaa	11	15	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:33624410C>T	uc003jia.1	-	14	2232	c.2069G>A	c.(2068-2070)CGC>CAC	p.R690H	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	690	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CACACCGCAGCGATCCTCGGT	0.502										HNSCC(64;0.19)			0	0	0	0.014758	0	5	49										T	33624410	C	T	33624410	3	4	9	1	0	0	0	0	1	0	0	0	257	768	27	2	2759	2	ADAMTS12	5	33624410	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		33624410	147290850	58	2438										
JMY	133746	broad.mit.edu	37	chr5	78610358	78610358	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggtgttacctctgaactgccTcccactatatctcttccact	5	15	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:78610358T>G	uc003kfx.3	+	9	2863	c.2343T>G	c.(2341-2343)CCT>CCG	p.P781P	JMY_uc003kfw.1_Silent_p.P427P	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	781	Pro-rich.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		CTGAACTGCCTCCCACTATAT	0.403													0	0	0	0.00308	0	6	103										G	78610358	T	G	78610358	2	3	9	1	0	0	0	0	0	0	0	1	7957	1538	54	5		5	JMY	5	78610358	Silent	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	44985948	78610358	102304902	59	2439										
RASGRF2	5924	broad.mit.edu	37	chr5	80390805	80390805	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctgcctggatgagtgacatCagtcaggtaagaaagtggct	14	7	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:80390805C>A	uc003kha.1	+	12	1749	c.1749C>A	c.(1747-1749)ATC>ATA	p.I583I	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	583	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGAGTGACATCAGTCAGGTAA	0.393													1	0	2.0095e-06	0.02938	2.22362e-06	6	37										A	80390805	C	A	80390805	2	1	9	1	0	0	0	0	0	0	0	1	13073	816	29	3		3	RASGRF2	5	80390805	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1780447	80390805	100524455	60	2440										
TRIM36	55521	broad.mit.edu	37	chr5	114499268	114499268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	taggggaggggagccgaagtCgaggactgctttgattggag	19	5	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:114499268C>T	uc003kqs.2	-	2	754	c.245G>A	c.(244-246)CGA>CAA	p.R82Q	TRIM36_uc011cwc.1_Missense_Mutation_p.R70Q|TRIM36_uc003kqt.2_Intron	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	82	RING-type; degenerate.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GAGCCGAAGTCGAGGACTGCT	0.448													0	0	0	0.014758	0	5	63										T	114499268	C	T	114499268	3	4	9	1	0	0	0	0	1	0	0	0	16507	884	31	1	1977	1	TRIM36	5	114499268	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	34108463	114499268	66415992	61	2441										
SLC12A2	6558	broad.mit.edu	37	chr5	127484463	127484463	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	taggctctatgtaaggacaaCatctacccagctttccagat	7	11	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:127484463C>T	uc003kus.2	+	12	2063	c.1899C>T	c.(1897-1899)AAC>AAT	p.N633N	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Silent_p.N633N	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	633	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTAAGGACAACATCTACCCAG	0.328													0	0	0	0.006214	0	10	112										T	127484463	C	T	127484463	2	4	9	1	0	0	0	0	0	0	0	1	14383	477	17	2		2	SLC12A2	5	127484463	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	12985195	127484463	53430797	62	2442										
KDM3B	51780	broad.mit.edu	37	chr5	137756428	137756428	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaggtcggtgctcaataaagAgtctcattcaccctttgggc	11	10	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:137756428A>G	uc003lcy.1	+	15	3949	c.3749A>G	c.(3748-3750)GAG>GGG	p.E1250G	KDM3B_uc010jew.1_Missense_Mutation_p.E906G|KDM3B_uc011cys.1_Missense_Mutation_p.E282G	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1250					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						CTCAATAAAGAGTCTCATTCA	0.483													0	0	0	0.010729	0	10	66										G	137756428	A	G	137756428	3	3	9	1	0	0	0	0	1	0	0	0	8127	304	11	5	3807	5	KDM3B	5	137756428	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	10271965	137756428	43158832	63	2443										
PCDHB2	56133	broad.mit.edu	37	chr5	140475832	140475832	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agagactcgggcaccaacgcCcaggtcacctactcgctgct	10	16	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:140475832C>G	uc003lil.2	+	1	1596	c.1458C>G	c.(1456-1458)GCC>GCG	p.A486A	PCDHB2_uc003lim.1_Silent_p.A147A	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	486	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACCAACGCCCAGGTCACCT	0.662													0	0	0	0.013537	0	6	111										G	140475832	C	G	140475832	2	3	9	1	0	0	0	0	0	0	0	1	11542	610	22	4		4	PCDHB2	5	140475832	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	2719404	140475832	40439428	64	2444										
C5orf58	133874	broad.mit.edu	37	chr5	169661182	169661182	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tccctgctcaggaaaaggtaGaggcaaggattgacttaaag	12	7	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:169661182G>A	uc010jjn.2	+	2	126	c.43G>A	c.(43-45)GAG>AAG	p.E15K	C5orf58_uc003mal.2_RNA	NM_001102609	NP_001096079	C9J3I9	CE058_HUMAN	hypothetical protein LOC133874	15											0						GGAAAAGGTAGAGGCAAGGAT	0.393													0	0	0	0.004672	0	3	28										A	169661182	G	A	169661182	3	1	9	1	0	0	0	0	1	0	0	0	2313	943	33	1	45	1	C5orf58	5	169661182	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	29185350	169661182	11254078	65	2445										
ZNF346	23567	broad.mit.edu	37	chr5	176468221	176468221	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tctgagtcccagaagctggcAcattaccaggtatgccatca	9	12	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr5:176468221A>T	uc003mfi.2	+	2	313	c.270A>T	c.(268-270)GCA>GCT	p.A90A	ZNF346_uc011dfr.1_Silent_p.A90A|ZNF346_uc011dfs.1_Intron|ZNF346_uc003mfj.2_Intron|ZNF346_uc003mfk.1_Silent_p.A115A|ZNF346_uc011dft.1_Intron	NM_012279	NP_036411	Q9UL40	ZN346_HUMAN	zinc finger protein 346	90	Matrin-type 1.					cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding				0	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAAGCTGGCACATTACCAGG	0.458													0	0	0	0.010729	0	12	110										T	176468221	A	T	176468221	2	4	9	1	0	0	0	0	0	0	0	1	17857	146	6	5		5	ZNF346	5	176468221	Silent	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	6807039	176468221	4447039	66	2446										
HIVEP1	3096	broad.mit.edu	37	chr6	12125108	12125108	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caacattacaaaaaggtcatCagaatgctttgccaaaccca	5	11	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:12125108C>T	uc003nac.2	+	4	5259	c.5080C>T	c.(5080-5082)CAG>TAG	p.Q1694*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1694					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AAAAGGTCATCAGAATGCTTT	0.393													0	0	0	0.028581	0	16	93										T	12125108	C	T	12125108	4	4	9	1	0	0	0	0	0	1	0	0	7186	827	29	1	5090	1	HIVEP1	6	12125108	Nonsense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		12125108	158989959	67	2447										
GPLD1	2822	broad.mit.edu	37	chr6	24472819	24472819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	attgctcttaccagcgtcgtGcaaggtaattaaaattaaat	7	7	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:24472819G>A	uc003ned.1	-	7	647	c.536C>T	c.(535-537)GCA>GTA	p.A179V	GPLD1_uc010jpr.1_Intron|GPLD1_uc010jps.1_Missense_Mutation_p.A179V	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	179						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						CCAGCGTCGTGCAAGGTAATT	0.338													0	0	0	0.013537	0	9	78										A	24472819	G	A	24472819	3	1	9	1	0	0	0	0	1	0	0	0	6614	1319	46	2	2062	2	GPLD1	6	24472819	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	12347711	24472819	146642248	68	2448										
GRM4	2914	broad.mit.edu	37	chr6	34003916	34003916	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcatccctagtcccaggaaGattcggcgcagcgagcaggt	12	13	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:34003916G>C	uc003oir.3	-	8	2141	c.1971C>G	c.(1969-1971)ATC>ATG	p.I657M	GRM4_uc011dsn.1_Missense_Mutation_p.I610M|GRM4_uc010jvh.2_Missense_Mutation_p.I657M|GRM4_uc010jvi.2_Missense_Mutation_p.I349M|GRM4_uc003oio.2_Missense_Mutation_p.I349M|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Missense_Mutation_p.I517M|GRM4_uc003oiq.2_Missense_Mutation_p.I524M|GRM4_uc011dsm.1_Missense_Mutation_p.I488M	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	657	Helical; Name=3; (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GTCCCAGGAAGATTCGGCGCA	0.602													0	0	0	0.014758	0	5	43										C	34003916	G	C	34003916	3	2	9	1	0	0	0	0	1	0	0	0	6799	932	33	1	779	1	GRM4	6	34003916	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	9531097	34003916	137111151	69	2449										
TEAD3	7005	broad.mit.edu	37	chr6	35454253	35454253	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cgcaccgtacatcttgccctCgtctgacaggatgatcttcc	8	15	3	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:35454253C>G	uc003oku.3	-	2	423	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	TEAD3_uc010jvx.2_Silent_p.T45T	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	63	TEA.				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATCTTGCCCTCGTCTGACAGG	0.697													0	0	0	0.014758	0	5	40										G	35454253	C	G	35454253	3	3	9	1	0	0	0	0	1	0	0	0	15737	893	31	1	1168	1	TEAD3	6	35454253	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1450337	35454253	135660814	70	2450										
BRPF3	27154	broad.mit.edu	37	chr6	36168658	36168658	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctgcagatacctttgagctgCtggtagaccggcttgagaaa	12	9	0	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:36168658C>T	uc003olv.3	+	2	783	c.559C>T	c.(559-561)CTG>TTG	p.L187L	BRPF3_uc010jwb.2_Silent_p.L187L|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.L187L	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	187					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CTTTGAGCTGCTGGTAGACCG	0.527													0	0	0	0.014758	0	4	55										T	36168658	C	T	36168658	2	4	9	1	0	0	0	0	0	0	0	1	1521	796	28	2		2	BRPF3	6	36168658	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	714405	36168658	134946409	71	2451										
PRPH2	5961	broad.mit.edu	37	chr6	42672298	42672298	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gagctaggattgcagcagctGaaagggacgccgtccaccag	14	11	0	1	rs61755799		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:42672298G>A	uc003osk.2	-	2	919	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	211	Lumenal (Potential).		F -> L (in RP7).		cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			TGCAGCAGCTGAAAGGGACGC	0.562													0	0	0	0.014758	0	5	51										A	42672298	G	A	42672298	2	1	9	1	0	0	0	0	0	0	0	1	12577	1281	45	1		1	PRPH2	6	42672298	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	6503640	42672298	128442769	72	2452										
GPR116	221395	broad.mit.edu	37	chr6	46849233	46849233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agttgtagtccattttgtagGtctgattgaggctctgtaca	11	6	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:46849233G>A	uc003oyo.3	-	8	1062	c.773C>T	c.(772-774)ACC>ATC	p.T258I	GPR116_uc003oyp.3_Missense_Mutation_p.T258I|GPR116_uc003oyq.3_Missense_Mutation_p.T258I|GPR116_uc010jzi.1_5'Flank|GPR116_uc003oyr.2_Missense_Mutation_p.T258I	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	258	SEA.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CATTTTGTAGGTCTGATTGAG	0.368													0	0	0	0.014758	0	5	66										A	46849233	G	A	46849233	3	1	9	1	0	0	0	0	1	0	0	0	6633	1261	44	2	3323	2	GPR116	6	46849233	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	4176935	46849233	124265834	73	2453										
DST	667	broad.mit.edu	37	chr6	56401661	56401661	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctagtgcttttggcagcactCtgaataaggccttgacctaa	9	10	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:56401661C>T	uc003pdf.2	-	56	10357	c.10329G>A	c.(10327-10329)CAG>CAA	p.Q3443Q	DST_uc003pcz.3_Silent_p.Q3265Q|DST_uc011dxj.1_Silent_p.Q3294Q|DST_uc011dxk.1_Silent_p.Q3305Q|DST_uc003pcy.3_Silent_p.Q2939Q	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5351	Spectrin 7.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGCAGCACTCTGAATAAGGC	0.433													0	0	0	0.014758	0	5	62										T	56401661	C	T	56401661	2	4	9	1	0	0	0	0	0	0	0	1	4783	912	32	1		1	DST	6	56401661	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	9552428	56401661	114713406	74	2454										
AKD1	221264	broad.mit.edu	37	chr6	109996891	109996891	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caaaaaattcctttcagtttCatcttcatcaaatatatctg	2	9	6	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:109996891C>T	uc003ptn.2	-	2	135	c.58G>A	c.(58-60)GAA>AAA	p.E20K	AKD1_uc003ptr.3_Missense_Mutation_p.E20K|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	20					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						CTTTCAGTTTCATCTTCATCA	0.289													0	0	0	0.009096	0	4	27										T	109996891	C	T	109996891	3	4	9	1	0	0	0	0	1	0	0	0	460	835	29	1	5849	1	AKD1	6	109996891	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	53595230	109996891	61118176	75	2455										
TSPYL1	7259	broad.mit.edu	37	chr6	116600201	116600201	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gatgtagttcctccgctccaGgtagtgtcgacgcatccgcc	11	14	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:116600201G>C	uc003pwp.3	-	1	1080	c.793C>G	c.(793-795)CTG>GTG	p.L265V	DSE_uc011ebf.1_Intron|DSE_uc003pwq.1_5'Flank|DSE_uc003pwr.2_5'Flank|DSE_uc003pws.2_5'Flank	NM_003309	NP_003300	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	265					nucleosome assembly	nucleolus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CTCCGCTCCAGGTAGTGTCGA	0.562													0	0	0	0.00308	0	8	84										C	116600201	G	C	116600201	3	2	9	1	0	0	0	0	1	0	0	0	16656	991	35	4	524	4	TSPYL1	6	116600201	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	6603310	116600201	54514866	76	2456										
MAP3K5	4217	broad.mit.edu	37	chr6	136904781	136904781	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtttcagctttgacagtgtgGtggctatgatttttcggtca	12	6	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr6:136904781G>A	uc003qhc.2	-	24	3684	c.3323C>T	c.(3322-3324)ACC>ATC	p.T1108I	MAP3K5_uc011edj.1_Missense_Mutation_p.T355I|MAP3K5_uc011edk.1_Missense_Mutation_p.T954I	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	1108					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGACAGTGTGGTGGCTATGAT	0.463													0	0	0	0.00308	0	8	67										A	136904781	G	A	136904781	3	1	9	1	0	0	0	0	1	0	0	0	9253	1261	44	2	829	2	MAP3K5	6	136904781	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	20304580	136904781	34210286	77	2457										
GET4	51608	broad.mit.edu	37	chr7	926266	926266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccctggagaaggcggaagtgGaggtggctgacgagctgctg	19	8	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:926266G>A	uc003sjl.1	+	3	387	c.295G>A	c.(295-297)GAG>AAG	p.E99K	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	99					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0						GGCGGAAGTGGAGGTGGCTGA	0.597													0	0	0	0.028581	0	15	67										A	926266	G	A	926266	3	1	9	1	0	0	0	0	1	0	0	0	6336	1175	41	1	305	1	GET4	7	926266	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		926266	158212397	78	2458										
INTS1	26173	broad.mit.edu	37	chr7	1513805	1513805	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gggcggcgggagcacacaccAgcagcaggcggatgaaggac	18	11	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:1513805A>G	uc003skn.2	-	41	5929	c.5828T>C	c.(5827-5829)CTG>CCG	p.L1943P	INTS1_uc003skm.1_Missense_Mutation_p.L80P	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1943					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGCACACACCAGCAGCAGGCG	0.706											OREG0017827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	13										G	1513805	A	G	1513805	3	3	9	1	0	0	0	0	1	0	0	0	7775	202	7	5	776	5	INTS1	7	1513805	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	587539	1513805	157624858	79	2459										
CHN2	1124	broad.mit.edu	37	chr7	29539546	29539546	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caatgactgccaacctgatcTcaagaggatcaagaaagtgt	9	9	2	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:29539546T>C	uc003szz.2	+	9	1240	c.803T>C	c.(802-804)CTC>CCC	p.L268P	CHN2_uc011jzs.1_Missense_Mutation_p.L343P|CHN2_uc010kva.2_Missense_Mutation_p.L38P|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.L233P|CHN2_uc011jzt.1_Missense_Mutation_p.L281P|CHN2_uc010kvd.2_Missense_Mutation_p.L124P|CHN2_uc011jzu.1_Missense_Mutation_p.L253P|CHN2_uc010kvg.2_Missense_Mutation_p.L132P|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Missense_Mutation_p.L132P|CHN2_uc010kve.2_Missense_Mutation_p.L132P|CHN2_uc003taa.2_Missense_Mutation_p.L132P|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Missense_Mutation_p.L87P|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.L87P|CHN2_uc011jzv.1_Missense_Mutation_p.L61P	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	268					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						CAACCTGATCTCAAGAGGATC	0.468													0	0	0	0.010729	0	12	46										C	29539546	T	C	29539546	3	2	9	1	0	0	0	0	1	0	0	0	3363	1551	54	5	1005	5	CHN2	7	29539546	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	28025741	29539546	129599117	80	2460										
AOAH	313	broad.mit.edu	37	chr7	36571798	36571798	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttgttggaagacatccagccGtggcaggggctgacctgaga	15	9	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:36571798G>A	uc003tfh.3	-	18	1781	c.1380C>T	c.(1378-1380)CAC>CAT	p.H460H	AOAH_uc010kxf.2_Silent_p.H460H|AOAH_uc011kba.1_Silent_p.H428H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	460					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						ACATCCAGCCGTGGCAGGGGC	0.512													0	0	0	0.00308	0	7	61										A	36571798	G	A	36571798	2	1	9	1	0	0	0	0	0	0	0	1	726	1136	40	2		2	AOAH	7	36571798	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	7032252	36571798	122566865	81	2461										
CUX1	1523	broad.mit.edu	37	chr7	101845239	101845239	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agtggcccagcgctgagtccCcatactcccagagctcagag	11	15	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:101845239C>G	uc003uyx.3	+	18	2700	c.2662C>G	c.(2662-2664)CCA>GCA	p.P888A	CUX1_uc003uys.3_Missense_Mutation_p.P899A|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	888					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						CGCTGAGTCCCCATACTCCCA	0.672													0	0	0	0.016723	0	12	61										G	101845239	C	G	101845239	3	3	9	1	0	0	0	0	1	0	0	0	4064	623	22	4	2799	4	CUX1	7	101845239	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	65273441	101845239	57293424	82	2462										
CAV1	857	broad.mit.edu	37	chr7	116166725	116166725	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aaccgcgaccctaaacacctCaacgatgacgtggtcaaggt	9	13	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr7:116166725C>G	uc003vif.1	+	2	455	c.177C>G	c.(175-177)CTC>CTG	p.L59L	CAV1_uc010lkd.1_Silent_p.L28L|CAV1_uc010lke.1_Silent_p.L28L|CAV1_uc003vig.1_RNA|CAV1_uc003vih.2_Silent_p.L28L|CAV1_uc010lkf.1_Silent_p.L28L	NM_001753	NP_001744	Q03135	CAV1_HUMAN	caveolin 1	59	Cytoplasmic (Potential).				blood coagulation|calcium ion transport|caveola assembly|cellular response to starvation|cholesterol homeostasis|cytosolic calcium ion homeostasis|inactivation of MAPK activity|interspecies interaction between organisms|leukocyte migration|lipid storage|maintenance of protein location in cell|mammary gland involution|membrane depolarization|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of endothelial cell proliferation|negative regulation of epithelial cell differentiation|negative regulation of nitric oxide biosynthetic process|negative regulation of peptidyl-serine phosphorylation|negative regulation of protein binding|negative regulation of transcription from RNA polymerase II promoter|nitric oxide homeostasis|nitric oxide metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of metalloenzyme activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of vasoconstriction|protein homooligomerization|receptor internalization|regulation of blood coagulation|regulation of fatty acid metabolic process|regulation of nitric-oxide synthase activity|regulation of smooth muscle contraction|response to calcium ion|response to estrogen stimulus|response to hypoxia|response to progesterone stimulus|skeletal muscle tissue development|T cell costimulation|triglyceride metabolic process|vasculogenesis|vesicle organization	apical plasma membrane|basolateral plasma membrane|caveola|caveola|cytosol|endoplasmic reticulum|endosome|Golgi membrane|lipid particle|perinuclear region of cytoplasm	cholesterol binding|nitric-oxide synthase binding|peptidase activator activity|protein binding|protein complex scaffold|receptor binding				0	all_epithelial(6;1.42e-06)|Lung NSC(10;0.0056)|all_lung(10;0.00609)		STAD - Stomach adenocarcinoma(10;0.00878)			CTAAACACCTCAACGATGACG	0.577											OREG0018273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	45										G	116166725	C	G	116166725	2	3	9	1	0	0	0	0	0	0	0	1	2693	813	29	1		1	CAV1	7	116166725	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	14321486	116166725	42971938	83	2463										
FNTA	2339	broad.mit.edu	37	chr8	42939973	42939973	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtggatatctatgaagacatGctagaaaatcagtgtgacaa	10	5	2	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr8:42939973G>A	uc003xps.2	+	8	1014	c.966G>A	c.(964-966)ATG>ATA	p.M322I	FNTA_uc003xpt.2_Missense_Mutation_p.M231I|FNTA_uc003xpu.2_Missense_Mutation_p.M255I|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	322					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			ATGAAGACATGCTAGAAAATC	0.358													0	0	0	0.021553	0	4	71										A	42939973	G	A	42939973	3	1	9	1	0	0	0	0	1	0	0	0	5977	1319	46	2	996	2	FNTA	8	42939973	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		42939973	103424049	84	2464										
MMP16	4325	broad.mit.edu	37	chr8	89198769	89198769	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atatcgctttcgacgaatatGaaatttggagctacctcttg	8	8	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr8:89198769G>A	uc003yeb.3	-	3	622	c.340C>T	c.(340-342)CAT>TAT	p.H114Y	MMP16_uc003yec.2_Missense_Mutation_p.H114Y	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	114					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						CGACGAATATGAAATTTGGAG	0.413													0	0	0	0.006214	0	9	154										A	89198769	G	A	89198769	3	1	9	1	0	0	0	0	1	0	0	0	9655	1290	45	1	1671	1	MMP16	8	89198769	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	46258796	89198769	57165253	85	2465										
PKHD1L1	93035	broad.mit.edu	37	chr8	110457514	110457514	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctgctcttgtgactcctctcCcagttggacatcattctgtt	7	13	4	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr8:110457514C>T	uc003yne.2	+	38	5520	c.5416C>T	c.(5416-5418)CCA>TCA	p.P1806S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1806	Extracellular (Potential).|IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACTCCTCTCCCAGTTGGACA	0.468										HNSCC(38;0.096)			0	0	0	0.02938	0	7	67										T	110457514	C	T	110457514	3	4	9	1	0	0	0	0	1	0	0	0	11972	623	22	2	5566	2	PKHD1L1	8	110457514	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	21258745	110457514	35906508	86	2466										
DOCK8	81704	broad.mit.edu	37	chr9	434792	434792	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tctgtcttcagaattgccaaGagttaccaggcatctcctga	8	11	4	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:434792G>A	uc003zgf.2	+	39	5008	c.4896G>A	c.(4894-4896)AAG>AAA	p.K1632K	DOCK8_uc010mgu.2_Silent_p.K934K|DOCK8_uc010mgv.2_Silent_p.K1532K|DOCK8_uc003zgk.2_Silent_p.K1090K	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1632	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GAATTGCCAAGAGTTACCAGG	0.478													0	0	0	0.014758	0	5	41										A	434792	G	A	434792	2	1	9	1	0	0	0	0	0	0	0	1	4693	933	33	1		1	DOCK8	9	434792	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		434792	140778639	87	2467										
RUSC2	9853	broad.mit.edu	37	chr9	35547473	35547473	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcagccactcagaccctggcGccttctatctggatctgcag	10	15	4	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:35547473G>A	uc003zww.2	+	2	1210	c.955G>A	c.(955-957)GCC>ACC	p.A319T	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.A319T	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	319						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			AGACCCTGGCGCCTTCTATCT	0.567													0	0	0	0.00308	0	7	61										A	35547473	G	A	35547473	3	1	9	1	0	0	0	0	1	0	0	0	13751	1087	38	2	957	2	RUSC2	9	35547473	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	35112681	35547473	105665958	88	2468										
FAM75A6	389730	broad.mit.edu	37	chr9	43625185	43625185	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tttctttgaaaaaatccactGaaaaaattgcttgatgtttt	5	5	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:43625185G>A	uc011lrb.1	-	4	3531	c.3502C>T	c.(3502-3504)CAG>TAG	p.Q1168*		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1168						integral to membrane					0						AAAATCCACTGAAAAAATTGC	0.428													0	0	0	0.013537	0	9	186										A	43625185	G	A	43625185	4	1	9	1	0	0	0	0	0	1	0	0	5622	1299	45	1	533	1	FAM75A6	9	43625185	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	8077712	43625185	97588246	89	2469										
C9orf3	84909	broad.mit.edu	37	chr9	97767884	97767884	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggaagcgcagggagaaggaaGaggtgtttgaaaaggtaggg	20	2	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:97767884G>C	uc004ava.2	+	12	2236	c.2101G>C	c.(2101-2103)GAG>CAG	p.E701Q	C9orf3_uc004auy.2_Missense_Mutation_p.E602Q|C9orf3_uc004auz.1_Missense_Mutation_p.E602Q|C9orf3_uc004avc.2_Missense_Mutation_p.E156Q|C9orf3_uc011luj.1_Missense_Mutation_p.E63Q|C9orf3_uc011luk.1_Missense_Mutation_p.E42Q|C9orf3_uc004avd.2_Missense_Mutation_p.E63Q|C9orf3_uc004ave.1_RNA	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	701					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GGAGAAGGAAGAGGTGTTTGA	0.522													0	0	0	0.00308	0	8	59										C	97767884	G	C	97767884	3	2	9	1	0	0	0	0	1	0	0	0	2477	943	33	1	1842	1	C9orf3	9	97767884	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	54142699	97767884	43445547	90	2470										
TDRD7	23424	broad.mit.edu	37	chr9	100249560	100249560	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acataagaaaagtacagcccCtagtggacatgttccgaaag	9	9	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:100249560C>T	uc004axj.2	+	16	3247	c.3022C>T	c.(3022-3024)CTA>TTA	p.L1008L	TDRD7_uc011lux.1_Silent_p.L934L|TDRD7_uc011luy.1_Silent_p.L328L	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	1008	Interacts with CDK17 (By similarity).|Interacts with CABLES1 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				AGTACAGCCCCTAGTGGACAT	0.433													0	0	0	0.00308	0	8	78										T	100249560	C	T	100249560	2	4	9	1	0	0	0	0	0	0	0	1	15732	680	24	2		2	TDRD7	9	100249560	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	2481676	100249560	40963871	91	2471										
EGFL7	51162	broad.mit.edu	37	chr9	139563050	139563050	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggctcacggggaccctgtctCcgagtcgttcgtgcagcgtg	15	13	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr9:139563050C>G	uc004cid.2	+	4	1033	c.122C>G	c.(121-123)TCC>TGC	p.S41C	EGFL7_uc004cif.2_Missense_Mutation_p.S41C|EGFL7_uc004cig.2_RNA|EGFL7_uc010nbp.2_Missense_Mutation_p.S41C|EGFL7_uc004cie.2_Missense_Mutation_p.S41C|EGFL7_uc004cih.2_Missense_Mutation_p.S41C|MIR126_hsa-mir-126|MI0000471_5'Flank	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	41	EMI.				angiogenesis|vasculogenesis		calcium ion binding			ovary(1)	1	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GACCCTGTCTCCGAGTCGTTC	0.677													0	0	0	0.008291	0	11	97										G	139563050	C	G	139563050	3	3	9	1	0	0	0	0	1	0	0	0	4964	855	30	1	128	1	EGFL7	9	139563050	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	39313490	139563050	1650381	92	2472										
C10orf18	54906	broad.mit.edu	37	chr10	5762896	5762896	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtatgctatgtgatatagctCtttggtccacttacggtgca	10	8	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:5762896C>G	uc001iij.2	+	6	734	c.109C>G	c.(109-111)CTT>GTT	p.L37V		NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	37										ovary(1)|central_nervous_system(1)	2						TGATATAGCTCTTTGGTCCAC	0.333													0	0	0	0.008291	0	11	71										G	5762896	C	G	5762896	3	3	9	1	0	0	0	0	1	0	0	0	1596	913	32	1	119	1	C10orf18	10	5762896	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		5762896	129771851	93	2473										
SEC61A2	55176	broad.mit.edu	37	chr10	12204226	12204226	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cggcaggtagctaaacagctGaaagaacagcagatggtaat	12	7	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:12204226G>T	uc001ile.2	+	11	1329	c.1182G>T	c.(1180-1182)CTG>CTT	p.L394L	SEC61A2_uc010qbq.1_Silent_p.L372L|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Silent_p.L394L	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	394	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				CTAAACAGCTGAAAGAACAGC	0.458													1	0	1.15088e-07	0.028581	1.29474e-07	14	193										T	12204226	G	T	12204226	2	4	9	1	0	0	0	0	0	0	0	1	14001	1277	45	3		3	SEC61A2	10	12204226	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	6441330	12204226	123330521	94	2474										
ERCC6	2074	broad.mit.edu	37	chr10	50732248	50732248	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tttcttctgccgtttcccgcCcttgggcagaggcttcagct	10	14	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:50732248C>T	uc001jhs.3	-	5	1382	c.1228G>A	c.(1228-1230)GGC>AGC	p.G410S	PGBD3_uc001jht.2_5'UTR|PGBD3_uc009xoe.2_Missense_Mutation_p.G410S|PGBD3_uc001jhu.2_Missense_Mutation_p.G410S	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	410					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CGTTTCCCGCCCTTGGGCAGA	0.393								Direct_reversal_of_damage|NER					0	0	0	0.004672	0	3	69										T	50732248	C	T	50732248	3	4	9	1	0	0	0	0	1	0	0	0	5217	623	22	2	3321	2	ERCC6	10	50732248	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	38528022	50732248	84802499	95	2475										
ARID5B	84159	broad.mit.edu	37	chr10	63829550	63829550	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cacttgtacccgcagacattAtgaaaggtaagaaaccattt	7	9	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:63829550A>G	uc001jlt.1	+	8	1219	c.1193A>G	c.(1192-1194)TAT>TGT	p.Y398C	ARID5B_uc001jlu.1_Missense_Mutation_p.Y155C	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	398	ARID.				liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CGCAGACATTATGAAAGGTAA	0.418													0	0	0	0.014758	0	4	31										G	63829550	A	G	63829550	3	3	9	1	0	0	0	0	1	0	0	0	922	449	16	5	1223	5	ARID5B	10	63829550	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	13097302	63829550	71705197	96	2476										
ACTA2	59	broad.mit.edu	37	chr10	90701132	90701132	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgtgggtgacaccatctccaGagtccagcacgatgcctggg	13	12	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:90701132G>A	uc001kfp.2	-	6	586	c.470C>T	c.(469-471)TCT>TTT	p.S157F	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.S112F|ACTA2_uc001kfq.2_Missense_Mutation_p.S157F	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	157					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		ACCATCTCCAGAGTCCAGCAC	0.562													0	0	0	0.014758	0	4	50										A	90701132	G	A	90701132	3	1	9	1	0	0	0	0	1	0	0	0	192	942	33	1	679	1	ACTA2	10	90701132	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	26871582	90701132	44833615	97	2477										
PDCD11	22984	broad.mit.edu	37	chr10	105182763	105182763	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agactctgtgttgatccagaCgctggccgagatgaccccag	12	12	1	5	rs142899352		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:105182763C>T	uc001kwy.1	+	18	2603	c.2516C>T	c.(2515-2517)ACG>ATG	p.T839M		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	839					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTGATCCAGACGCTGGCCGAG	0.527													0	0	0	0.009096	0	3	49										T	105182763	C	T	105182763	3	4	9	1	0	0	0	0	1	0	0	0	11617	536	19	2	2582	2	PDCD11	10	105182763	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	14481631	105182763	30351984	98	2478										
C10orf79	80217	broad.mit.edu	37	chr10	105953694	105953694	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aggggattccttatcatataCgctgatgaagtagaccgagc	11	8	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:105953694C>T	uc001kxw.2	-	11	1488	c.1372G>A	c.(1372-1374)GTA>ATA	p.V458I	C10orf79_uc001kxx.3_Missense_Mutation_p.V459I|C10orf79_uc001kxy.1_Missense_Mutation_p.V459I	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	458	WD 7.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTATCATATACGCTGATGAAG	0.552													0	0	0	0.008291	0	11	58										T	105953694	C	T	105953694	3	4	9	1	0	0	0	0	1	0	0	0	1618	536	19	2	3737	2	C10orf79	10	105953694	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	770931	105953694	29581053	99	2479										
SORCS3	22986	broad.mit.edu	37	chr10	106982877	106982877	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tttttctgtttccttaggtcCtgtggagcatgttcatctcc	8	10	3	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:106982877C>A	uc001kyi.1	+	20	2965	c.2738C>A	c.(2737-2739)CCT>CAT	p.P913H	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	913	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TCCTTAGGTCCTGTGGAGCAT	0.428													1	0	7.48243e-07	0.006214	8.31381e-07	10	83										A	106982877	C	A	106982877	3	1	9	1	0	0	0	0	1	0	0	0	14932	681	24	4	2816	4	SORCS3	10	106982877	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1029183	106982877	28551870	100	2480										
ATRNL1	26033	broad.mit.edu	37	chr10	117704277	117704277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acacctttcaacacgtcaagGaacttgtgtctgagaaatgg	9	9	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:117704277G>A	uc001lcg.2	+	29	4513	c.4127G>A	c.(4126-4128)GGA>GAA	p.G1376E	ATRNL1_uc010qsm.1_Missense_Mutation_p.G505E|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1376	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACACGTCAAGGAACTTGTGTC	0.413													0	0	0	0.024245	0	14	91										A	117704277	G	A	117704277	3	1	9	1	0	0	0	0	1	0	0	0	1207	1174	41	1	4241	1	ATRNL1	10	117704277	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	10721400	117704277	17830470	101	2481										
INPP5F	22876	broad.mit.edu	37	chr10	121563770	121563770	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agtgttgcttttcaacaactCacacctcacttacgtttcgt	5	12	3	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr10:121563770C>T	uc001leo.2	+	10	1368	c.1202C>T	c.(1201-1203)TCA>TTA	p.S401L		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	401	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TTCAACAACTCACACCTCACT	0.418													0	0	0	0.008291	0	10	108										T	121563770	C	T	121563770	3	4	9	1	0	0	0	0	1	0	0	0	7758	838	29	1	1240	1	INPP5F	10	121563770	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3859493	121563770	13970977	102	2482										
DUSP8	1850	broad.mit.edu	37	chr11	1579411	1579411	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gttgtcgttgatggggacccGcatgaagcggctctcgcaga	15	10	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:1579411G>A	uc001lts.2	-	5	756	c.628C>T	c.(628-630)CGG>TGG	p.R210W		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	210	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		ATGGGGACCCGCATGAAGCGG	0.582													0	0	0	0.009096	0	4	104										A	1579411	G	A	1579411	3	1	9	1	0	0	0	0	1	0	0	0	4831	1086	38	2	1261	2	DUSP8	11	1579411	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		1579411	133427105	103	2483										
TNNI2	7136	broad.mit.edu	37	chr11	1861878	1861878	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atatcccgggctccatgtctGaagtgcaggtaccagcccct	10	14	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:1861878G>A	uc010qxe.1	+	3	200	c.178G>A	c.(178-180)GAA>AAA	p.E60K	TNNI2_uc010qxc.1_Missense_Mutation_p.E58K|TNNI2_uc010qxd.1_Missense_Mutation_p.E58K	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	60					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CTCCATGTCTGAAGTGCAGGT	0.667													0	0	0	0.014758	0	4	32										A	1861878	G	A	1861878	3	1	9	1	0	0	0	0	1	0	0	0	16324	1291	45	1	207	1	TNNI2	11	1861878	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	282467	1861878	133144638	104	2484										
OR51S1	119692	broad.mit.edu	37	chr11	4869937	4869937	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	catgtaggccagcaggaatgGcaggggcagatggagaccca	16	9	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:4869937G>A	uc010qyo.1	-	1	502	c.502C>T	c.(502-504)CCA>TCA	p.P168S		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	168	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCAGGAATGGCAGGGGCAGA	0.552													0	0	0	0.02938	0	5	92										A	4869937	G	A	4869937	3	1	9	1	0	0	0	0	1	0	0	0	11105	1203	42	2	472	2	OR51S1	11	4869937	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	3008059	4869937	130136579	105	2485										
SMPD1	6609	broad.mit.edu	37	chr11	6415196	6415196	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aatttgaggtcttctatgatGaagagactctgagccggccg	12	8	3	5			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:6415196G>A	uc001mcw.2	+	5	1585	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	SMPD1_uc001mcv.1_RNA|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.E427K|SMPD1_uc009yew.2_Missense_Mutation_p.E470K	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	469					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CTTCTATGATGAAGAGACTCT	0.527													0	0	0	0.02938	0	7	65										A	6415196	G	A	6415196	3	1	9	1	0	0	0	0	1	0	0	0	14804	1291	45	1	1469	1	SMPD1	11	6415196	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1545259	6415196	128591320	106	2486										
EIF4G2	1982	broad.mit.edu	37	chr11	10821761	10821761	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggaaaatgggtgccactttcTagtggttgagctagttctga	13	6	2	2	rs140144694		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:10821761T>C	uc001mjc.2	-	18	2412	c.1995A>G	c.(1993-1995)CTA>CTG	p.L665L	EIF4G2_uc001mjb.2_Silent_p.L459L|EIF4G2_uc009ygf.2_Silent_p.L459L|EIF4G2_uc001mjd.2_Silent_p.L627L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	665	MI.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TGCCACTTTCTAGTGGTTGAG	0.423													0	0	0	0.008291	0	11	49										C	10821761	T	C	10821761	2	2	9	1	0	0	0	0	0	0	0	1	5037	1509	53	5		5	EIF4G2	11	10821761	Silent	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	4406565	10821761	124184755	107	2487										
MICAL2	9645	broad.mit.edu	37	chr11	12265655	12265655	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgactctgcttctcctgccaGaaaggtagttgtcctgaaca	9	11	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:12265655G>A	uc001mjz.2	+	21	3068	c.2780G>A	c.(2779-2781)AGA>AAA	p.R927K	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Missense_Mutation_p.R927K|MICAL2_uc010rci.1_Missense_Mutation_p.R927K|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	927						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCTCCTGCCAGAAAGGTAGTT	0.502													0	0	0	0.0333	0	14	187										A	12265655	G	A	12265655	3	1	9	1	0	0	0	0	1	0	0	0	9570	942	33	1	2854	1	MICAL2	11	12265655	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1443894	12265655	122740861	108	2488										
ABCC8	6833	broad.mit.edu	37	chr11	17474774	17474774	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aacagaagcacagctaagacGtaggcattggcaaggaactc	11	9	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:17474774G>A	uc001mnc.2	-	7	1194	c.1068C>T	c.(1066-1068)TAC>TAT	p.Y356Y	ABCC8_uc010rcy.1_Silent_p.Y355Y	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	356	Helical; Name=7; (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CAGCTAAGACGTAGGCATTGG	0.458													0	0	0	0.014758	0	4	70										A	17474774	G	A	17474774	2	1	9	1	0	0	0	0	0	0	0	1	58	1140	40	2		2	ABCC8	11	17474774	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	5209119	17474774	117531742	109	2489										
LMO2	4005	broad.mit.edu	37	chr11	33886306	33886306	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cggtccccaatgttctgctgGcagccgccgcatgtcagcag	12	15	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:33886306G>T	uc001mve.2	-	2	538	c.99C>A	c.(97-99)TGC>TGA	p.C33*	LMO2_uc001mvc.2_Nonsense_Mutation_p.C26*|LMO2_uc001mvd.2_Nonsense_Mutation_p.C26*|LMO2_uc010rel.1_Nonsense_Mutation_p.C33*|LMO2_uc010rem.1_Nonsense_Mutation_p.C102*	NM_001142316	NP_001135788	P25791	RBTN2_HUMAN	LIM domain only 2 isoform 2	33	LIM zinc-binding 1.				multicellular organismal development	nucleus	protein binding|zinc ion binding			lung(1)	1						TGTTCTGCTGGCAGCCGCCGC	0.627			T	TRD@	T-ALL								1	0	5.9392e-07	0.021553	6.62638e-07	6	48										T	33886306	G	T	33886306	4	4	9	1	0	0	0	0	0	1	0	0	8852	1195	42	4	385	4	LMO2	11	33886306	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	16411532	33886306	101120210	110	2490										
TM7SF2	7108	broad.mit.edu	37	chr11	64883439	64883439	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgcaccgtgaggcccgggatGagcggcagtgcctgcagaag	17	11	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:64883439G>C	uc001oct.2	+	10	1318	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	TM7SF2_uc010rny.1_Missense_Mutation_p.E275Q|TM7SF2_uc001ocu.2_Missense_Mutation_p.E364Q|TM7SF2_uc001ocv.2_Missense_Mutation_p.E412Q|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	391					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						GGCCCGGGATGAGCGGCAGTG	0.622													0	0	0	0.009096	0	4	36										C	64883439	G	C	64883439	3	2	9	1	0	0	0	0	1	0	0	0	15971	1291	45	1	1209	1	TM7SF2	11	64883439	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	30997133	64883439	70123077	111	2491										
MOGAT2	80168	broad.mit.edu	37	chr11	75439097	75439097	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttgctgggcatcattgtaggGggtgcccaggaggccctgga	17	9	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:75439097G>A	uc010rru.1	+	4	558	c.558G>A	c.(556-558)GGG>GGA	p.G186G	MOGAT2_uc001oww.1_Silent_p.G186G|MOGAT2_uc010rrv.1_Silent_p.G104G	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	186					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					TCATTGTAGGGGGTGCCCAGG	0.562													0	0	0	0.004672	0	3	38										A	75439097	G	A	75439097	2	1	9	1	0	0	0	0	0	0	0	1	9695	1219	43	2		2	MOGAT2	11	75439097	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	10555658	75439097	59567419	112	2492										
PCF11	51585	broad.mit.edu	37	chr11	82877725	82877725	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aaagttccaagtctgccaaaAgatggaaatctggttgggaa	11	6	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:82877725A>C	uc001ozx.3	+	5	2131	c.1786A>C	c.(1786-1788)AGA>CGA	p.R596R	PCF11_uc010rsu.1_Silent_p.R596R	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	596					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GTCTGCCAAAAGATGGAAATC	0.348													0	0	0	0.014758	0	4	75										C	82877725	A	C	82877725	2	2	9	1	0	0	0	0	0	0	0	1	11573	64	3	5		5	PCF11	11	82877725	Silent	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	7438628	82877725	52128791	113	2493										
FAT3	120114	broad.mit.edu	37	chr11	92087450	92087450	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	attaatagacagggaccataTtttgacaagtcttttccttc	6	8	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:92087450T>G	uc001pdj.3	+	1	2189	c.2172T>G	c.(2170-2172)TAT>TAG	p.Y724*		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	724	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGGACCATATTTTGACAAGT	0.403										TCGA Ovarian(4;0.039)			0	0	0	0.010504	0	18	155										G	92087450	T	G	92087450	4	3	9	1	0	0	0	0	0	1	0	0	5691	1500	52	5	2174	5	FAT3	11	92087450	Nonsense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	9209725	92087450	42919066	114	2494										
CCDC67	159989	broad.mit.edu	37	chr11	93103298	93103298	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atattatatcagactcatctGatttctttagatgctcaaca	4	8	5	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:93103298G>C	uc001pdq.2	+	6	592	c.492G>C	c.(490-492)CTG>CTC	p.L164L	CCDC67_uc001pdo.1_Silent_p.L164L|CCDC67_uc001pdp.2_Silent_p.L164L	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	164	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AGACTCATCTGATTTCTTTAG	0.289													0	0	0	0.014758	0	5	14										C	93103298	G	C	93103298	2	2	9	1	0	0	0	0	0	0	0	1	2839	1277	45	1		1	CCDC67	11	93103298	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1015848	93103298	41903218	115	2495										
CASP5	838	broad.mit.edu	37	chr11	104868181	104868181	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgtgatgagttccgtaatgaAgatggagccccttgtgcggt	14	7	0	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:104868181A>C	uc010rva.1	-	8	1167	c.1135T>G	c.(1135-1137)TTC>GTC	p.F379V	CASP5_uc010ruz.1_Missense_Mutation_p.F392V|CASP5_uc010rvb.1_Missense_Mutation_p.F321V|CASP5_uc010rvc.1_Missense_Mutation_p.F237V|CASP5_uc009yxh.2_Missense_Mutation_p.F161V|CASP5_uc010rvd.1_Missense_Mutation_p.F161V	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	379					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TCCGTAATGAAGATGGAGCCC	0.408													0	0	0	0.02938	0	6	39										C	104868181	A	C	104868181	3	2	9	1	0	0	0	0	1	0	0	0	2674	72	3	5	177	5	CASP5	11	104868181	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	11764883	104868181	30138335	116	2496										
ARCN1	372	broad.mit.edu	37	chr11	118452000	118452000	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tctgcacaaaagcaggaaagGctattgtttctcgacagttt	9	8	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:118452000G>A	uc001ptq.2	+	2	204	c.43G>A	c.(43-45)GCT>ACT	p.A15T	ARCN1_uc009zah.2_Missense_Mutation_p.A15T|ARCN1_uc010ryg.1_Intron|ARCN1_uc009zag.2_Missense_Mutation_p.A56T	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	15					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AGCAGGAAAGGCTATTGTTTC	0.428													0	0	0	0.020292	0	12	109										A	118452000	G	A	118452000	3	1	9	1	0	0	0	0	1	0	0	0	842	1203	42	2	49	2	ARCN1	11	118452000	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	13583819	118452000	16554516	117	2497										
IGSF9B	22997	broad.mit.edu	37	chr11	133794727	133794727	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caaaatacctgtgctggagaCgccggcgatgttgctgggct	14	10	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr11:133794727C>T	uc001qgx.3	-	15	2338	c.2107G>A	c.(2107-2109)GTC>ATC	p.V703I	IGSF9B_uc001qgy.1_Missense_Mutation_p.V545I	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	703	Fibronectin type-III 2.|Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GTGCTGGAGACGCCGGCGATG	0.562													0	0	0	0.014758	0	4	94										T	133794727	C	T	133794727	3	4	9	1	0	0	0	0	1	0	0	0	7606	536	19	2	1962	2	IGSF9B	11	133794727	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	15342727	133794727	1211789	118	2498										
SCNN1A	6337	broad.mit.edu	37	chr12	6483849	6483849	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctgctggggcgccgcaggtTcggggcccagcccctgctcc	16	17	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:6483849T>C	uc001qnx.2	-	2	390	c.101A>G	c.(100-102)GAA>GGA	p.E34G	SCNN1A_uc001qnw.2_Missense_Mutation_p.E93G|SCNN1A_uc010sfb.1_Missense_Mutation_p.E57G|LTBR_uc010sfc.1_5'Flank	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	34	Cytoplasmic (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CGCCGCAGGTTCGGGGCCCAG	0.642													0	0	0	0.004672	0	3	34										C	6483849	T	C	6483849	3	2	9	1	0	0	0	0	1	0	0	0	13927	1783	62	5	1956	5	SCNN1A	12	6483849	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08		6483849	127368046	119	2499										
CLEC1B	51266	broad.mit.edu	37	chr12	10149501	10149501	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	attcatgtcagtgcagtactGcttactctcttcccatgtta	6	11	3	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:10149501G>A	uc001qwu.2	-	4	582	c.382C>T	c.(382-384)CAG>TAG	p.Q128*	CLEC1B_uc009zhd.2_Nonsense_Mutation_p.Q95*	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	128	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						GTGCAGTACTGCTTACTCTCT	0.423													0	0	0	0.021553	0	6	127										A	10149501	G	A	10149501	4	1	9	1	0	0	0	0	0	1	0	0	3506	1328	46	2	319	2	CLEC1B	12	10149501	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	3665652	10149501	123702394	120	2500										
ETV6	2120	broad.mit.edu	37	chr12	12037408	12037408	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgctttgggattacgtctatCagttgctttctgacagccgg	11	9	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:12037408C>T	uc001qzz.2	+	6	1313	c.1039C>T	c.(1039-1041)CAG>TAG	p.Q347*	ETV6_uc001raa.1_Intron	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	347	ETS.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				TTACGTCTATCAGTTGCTTTC	0.443			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								0	0	0	0.028581	0	14	136										T	12037408	C	T	12037408	4	4	9	1	0	0	0	0	0	1	0	0	5283	827	29	1	1061	1	ETV6	12	12037408	Nonsense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1887907	12037408	121814487	121	2501										
AMN1	196394	broad.mit.edu	37	chr12	31850769	31850769	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acttaagcagccacctaaatCgatgatctttagcagctggc	8	11	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:31850769C>T	uc001rkq.3	-	4	605	c.439G>A	c.(439-441)GAT>AAT	p.D147N	AMN1_uc001rko.3_Missense_Mutation_p.D129N|AMN1_uc010skc.1_Missense_Mutation_p.D129N|AMN1_uc001rkp.3_Missense_Mutation_p.D129N|AMN1_uc009zjs.2_RNA|AMN1_uc009zjt.1_RNA	NM_001113402	NP_001106873	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog	147											0	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			CCACCTAAATCGATGATCTTT	0.418													0	0	0	0.009096	0	4	75										T	31850769	C	T	31850769	3	4	9	1	0	0	0	0	1	0	0	0	581	884	31	1	353	1	AMN1	12	31850769	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	19813361	31850769	102001126	122	2502										
AMIGO2	347902	broad.mit.edu	37	chr12	47472350	47472350	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtgattgttgtaaagcagaaGcacttccagaaccttcaact	8	9	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:47472350G>T	uc001rpm.2	-	3	1091	c.436C>A	c.(436-438)CTT>ATT	p.L146I	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Missense_Mutation_p.L146I|AMIGO2_uc001rpl.2_Missense_Mutation_p.L146I	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	146	Extracellular (Potential).|LRR 4.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					TAAAGCAGAAGCACTTCCAGA	0.408													1	0	5.18039e-06	0.00308	5.6858e-06	8	107										T	47472350	G	T	47472350	3	4	9	1	0	0	0	0	1	0	0	0	576	971	34	4	1136	4	AMIGO2	12	47472350	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	15621581	47472350	86379545	123	2503										
ACCN2	41	broad.mit.edu	37	chr12	50453726	50453726	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gggaggtctgcagcgctgaaGacttcaaggtggtgagtccc	16	9	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:50453726G>A	uc001rvw.2	+	3	776	c.547G>A	c.(547-549)GAC>AAC	p.D183N	ACCN2_uc001rvv.2_Missense_Mutation_p.D183N|ACCN2_uc009zln.2_5'UTR|ACCN2_uc009zlo.2_Missense_Mutation_p.D183N	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	183	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	CAGCGCTGAAGACTTCAAGGT	0.617													0	0	0	0.014758	0	5	39										A	50453726	G	A	50453726	3	1	9	1	0	0	0	0	1	0	0	0	129	942	33	1	553	1	ACCN2	12	50453726	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	2981376	50453726	83398169	124	2504										
SLC4A8	9498	broad.mit.edu	37	chr12	51890800	51890800	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttggtctttgtcaggaaagtCatggatctctgtttctctaa	9	7	5	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:51890800C>G	uc001rys.1	+	22	3151	c.2973C>G	c.(2971-2973)GTC>GTG	p.V991V	SLC4A8_uc001rym.2_Silent_p.V938V|SLC4A8_uc001ryn.2_Silent_p.V938V|SLC4A8_uc001ryo.2_Silent_p.V938V|SLC4A8_uc010snj.1_Silent_p.V1018V|SLC4A8_uc001ryr.2_Silent_p.V991V	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	991	Cytoplasmic (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCAGGAAAGTCATGGATCTCT	0.398													0	0	0	0.021553	0	5	75										G	51890800	C	G	51890800	2	3	9	1	0	0	0	0	0	0	0	1	14659	813	29	1		1	SLC4A8	12	51890800	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1437074	51890800	81961095	125	2505										
RARG	5916	broad.mit.edu	37	chr12	53607445	53607445	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cccgtcggagaaggtcatggTgtcctgctctggggtgtacc	15	11	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:53607445T>C	uc001sce.2	-	8	1338	c.853A>G	c.(853-855)ACC>GCC	p.T285A	RARG_uc001scd.2_Missense_Mutation_p.T274A|RARG_uc010sob.1_Missense_Mutation_p.T263A|RARG_uc001scf.2_Missense_Mutation_p.T285A|RARG_uc001scg.2_Missense_Mutation_p.T213A|RARG_uc010soc.1_Missense_Mutation_p.T164A|RARG_uc010sod.1_Missense_Mutation_p.T322A	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	285	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AAGGTCATGGTGTCCTGCTCT	0.597											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	57										C	53607445	T	C	53607445	3	2	9	1	0	0	0	0	1	0	0	0	13054	1696	59	5	523	5	RARG	12	53607445	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	1716645	53607445	80244450	126	2506										
ZNF385A	25946	broad.mit.edu	37	chr12	54765456	54765456	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gatggggagccaggctgtttCtctggggatcctggggctgg	19	8	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:54765456C>T	uc001sfw.1	-	4	588	c.405G>A	c.(403-405)GAG>GAA	p.E135E	ZNF385A_uc001sfv.1_Silent_p.E116E|ZNF385A_uc009zno.1_Intron|ZNF385A_uc010sov.1_Intron|ZNF385A_uc001sfx.1_Silent_p.E135E|ZNF385A_uc001sfy.3_Silent_p.E155E|ZNF385A_uc001sfz.3_Intron	NM_015481	NP_056296	Q96PM9	Z385A_HUMAN	zinc finger protein 385A isoform c	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1						CAGGCTGTTTCTCTGGGGATC	0.602													0	0	0	0.020292	0	13	63										T	54765456	C	T	54765456	2	4	9	1	0	0	0	0	0	0	0	1	17873	912	32	1		1	ZNF385A	12	54765456	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1158011	54765456	79086439	127	2507										
RNF41	10193	broad.mit.edu	37	chr12	56600547	56600547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcgagatcatccctccccagCgggtcactcttgctggctga	10	15	3	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:56600547C>T	uc001skf.1	-	7	1007	c.638G>A	c.(637-639)CGC>CAC	p.R213H	RNF41_uc001ske.1_Missense_Mutation_p.R142H|RNF41_uc001skg.1_Missense_Mutation_p.R213H|RNF41_uc010sqg.1_Missense_Mutation_p.R148H|RNF41_uc010sqh.1_Missense_Mutation_p.R142H	NM_005785	NP_005776	Q9H4P4	RNF41_HUMAN	ring finger protein 41 isoform 1	213					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1						CCCTCCCCAGCGGGTCACTCT	0.537											OREG0021921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	31										T	56600547	C	T	56600547	3	4	9	1	0	0	0	0	1	0	0	0	13494	768	27	2	319	2	RNF41	12	56600547	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1835091	56600547	77251348	128	2508										
LGR5	8549	broad.mit.edu	37	chr12	71977788	71977788	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctggagcgtgggttctctgtGaaatattctgcaaaatttga	11	6	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:71977788G>A	uc001swl.2	+	18	2046	c.1998G>A	c.(1996-1998)GTG>GTA	p.V666V	LGR5_uc001swm.2_Silent_p.V642V|LGR5_uc001swn.1_Intron	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	666	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						GGTTCTCTGTGAAATATTCTG	0.463													0	0	0	0.016723	0	13	142										A	71977788	G	A	71977788	2	1	9	1	0	0	0	0	0	0	0	1	8757	1277	45	1		1	LGR5	12	71977788	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	15377241	71977788	61874107	129	2509										
TRHDE	29953	broad.mit.edu	37	chr12	73046177	73046177	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaggatgtctgggaattcatAtggatgaaattccattccac	10	7	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:73046177A>G	uc001sxa.2	+	16	2646	c.2616A>G	c.(2614-2616)ATA>ATG	p.I872M		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	872	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGGAATTCATATGGATGAAAT	0.398													0	0	0	0.021553	0	6	74										G	73046177	A	G	73046177	3	3	9	1	0	0	0	0	1	0	0	0	16476	439	16	5	2678	5	TRHDE	12	73046177	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	1068389	73046177	60805718	130	2510										
HSP90B1	7184	broad.mit.edu	37	chr12	104336352	104336352	+	Silent	SNP	G	G	A													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acgctggacatgatcaagaaGattgctgatgataaatacaa							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:104336352G>A	uc001tkb.1	+	12	1527	c.1422G>A	c.(1420-1422)AAG>AAA	p.K474K	HSP90B1_uc010swg.1_Silent_p.K139K|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	474					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	TGATCAAGAAGATTGCTGATG	0.363													0	0	0	0.009096	0	4	54										A	104336352	G	A	104336352	2	1	9	1	0	0	0	0	0	0	0	1	7403	933	33	1		1	HSP90B1	12	104336352	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	31290175	104336352	29515543	131	2511	15	2								
HSP90B1	7184	broad.mit.edu	37	chr12	104336359	104336359	+	Missense_Mutation	SNP	G	G	T													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acatgatcaagaagattgctGatgataaatacaatgatact							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:104336359G>T	uc001tkb.1	+	12	1534	c.1429G>T	c.(1429-1431)GAT>TAT	p.D477Y	HSP90B1_uc010swg.1_Missense_Mutation_p.D142Y|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	477					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GAAGATTGCTGATGATAAATA	0.363													1	0	0.00909568	0.009096	0.00944551	4	59										T	104336359	G	T	104336359	3	4	9	1	0	0	0	0	1	0	0	0	7403	1290	45	3	1475	3	HSP90B1	12	104336359	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	7	104336359	29515536	132	2512	15	2								
HSP90B1	7184	broad.mit.edu	37	chr12	104336567	104336567	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cttcatggctgggtccagcaGaaaagaggtgagatgaactc	13	8	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:104336567G>C	uc001tkb.1	+	12	1742	c.1637G>C	c.(1636-1638)AGA>ACA	p.R546T	HSP90B1_uc010swg.1_Missense_Mutation_p.R211T|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	546					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GGGTCCAGCAGAAAAGAGGTG	0.418													0	0	0	0.021553	0	6	71										C	104336567	G	C	104336567	3	2	9	1	0	0	0	0	1	0	0	0	7403	942	33	1	1683	1	HSP90B1	12	104336567	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	208	104336567	29515328	133	2513										
CIT	11113	broad.mit.edu	37	chr12	120159203	120159203	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttcttgcagtccttgagtcaGacggaaaatgtgatttttct	9	7	3	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:120159203G>A	uc001txi.1	-	28	3570	c.3517C>T	c.(3517-3519)CTG>TTG	p.L1173L	CIT_uc001txh.1_Silent_p.L707L|CIT_uc001txj.1_Silent_p.L1215L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1173	Potential.|Interaction with Rho/Rac.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CCTTGAGTCAGACGGAAAATG	0.468													0	0	0	0.010729	0	11	62										A	120159203	G	A	120159203	2	1	9	1	0	0	0	0	0	0	0	1	3438	933	33	1		1	CIT	12	120159203	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	15822636	120159203	13692692	134	2514										
GLT1D1	144423	broad.mit.edu	37	chr12	129373237	129373237	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaactgatgtaaatgaagatGccaaccaggcggaaaaaaac	10	7	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:129373237G>A	uc010tbh.1	+	3	247	c.238G>A	c.(238-240)GCC>ACC	p.A80T	GLT1D1_uc001uhx.1_Missense_Mutation_p.A91T|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	91					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		AAATGAAGATGCCAACCAGGC	0.438													0	0	0	0.009096	0	4	23										A	129373237	G	A	129373237	3	1	9	1	0	0	0	0	1	0	0	0	6465	1319	46	2	281	2	GLT1D1	12	129373237	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	9214034	129373237	4478658	135	2515										
GOLGA3	2802	broad.mit.edu	37	chr12	133374950	133374950	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atgccctgcagctgtgccgcGatgcgccccttctccttcat	9	17	2	0	rs139706790		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr12:133374950G>T	uc001ukz.1	-	9	2473	c.1914C>A	c.(1912-1914)ATC>ATA	p.I638I	GOLGA3_uc001ula.1_Silent_p.I638I|GOLGA3_uc001ulb.2_Silent_p.I638I	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	638	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTGTGCCGCGATGCGCCCCT	0.587													1	0	8.12818e-05	0.02938	8.77844e-05	7	87										T	133374950	G	T	133374950	2	4	9	1	0	0	0	0	0	0	0	1	6554	1048	37	3		3	GOLGA3	12	133374950	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	4001713	133374950	476945	136	2516										
TNFRSF19	55504	broad.mit.edu	37	chr13	24243107	24243107	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tctgaaaactttacagcagcTactgatttatctagatataa	5	7	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr13:24243107T>C	uc001uov.1	+	9	1180	c.1116T>C	c.(1114-1116)GCT>GCC	p.A372A	TNFRSF19_uc001uot.2_Silent_p.A372A|TNFRSF19_uc010tcu.1_Silent_p.A240A|TNFRSF19_uc001uow.2_Silent_p.A372A	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	372	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TTACAGCAGCTACTGATTTAT	0.428													0	0	0	0.004672	0	3	86										C	24243107	T	C	24243107	2	2	9	1	0	0	0	0	0	0	0	1	16289	1509	53	5		5	TNFRSF19	13	24243107	Silent	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08		24243107	90926771	137	2517										
FAM123A	219287	broad.mit.edu	37	chr13	25744014	25744014	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agatacgggctttaaccgggAcagggaggacgtctcctcgt	14	10	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr13:25744014A>T	uc001uqb.2	-	1	1844	c.1744T>A	c.(1744-1746)TCC>ACC	p.S582T	FAM123A_uc001uqa.2_Missense_Mutation_p.S463T|FAM123A_uc001uqc.2_Missense_Mutation_p.S463T	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	582										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TTTAACCGGGACAGGGAGGAC	0.567													0	0	0	0.021553	0	3	70										T	25744014	A	T	25744014	3	4	9	1	0	0	0	0	1	0	0	0	5422	275	10	5	275	5	FAM123A	13	25744014	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	1500907	25744014	89425864	138	2518										
KIAA0564	23078	broad.mit.edu	37	chr13	42385394	42385394	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctttagtaacagcactgtgaAgattttcattaggatactgt	8	6	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr13:42385394A>C	uc001uyj.2	-	17	2100	c.2030T>G	c.(2029-2031)CTT>CGT	p.L677R	KIAA0564_uc001uyk.2_Missense_Mutation_p.L677R	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	677						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		AGCACTGTGAAGATTTTCATT	0.383													0	0	0	0.02938	0	6	53										C	42385394	A	C	42385394	3	2	9	1	0	0	0	0	1	0	0	0	8185	72	3	5	3807	5	KIAA0564	13	42385394	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	16641380	42385394	72784484	139	2519										
NID2	22795	broad.mit.edu	37	chr14	52481073	52481073	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	attgaggggtaagtagccaaTctgctggccctgagtataga	13	7	1	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:52481073T>C	uc001wzo.2	-	16	3586	c.3352A>G	c.(3352-3354)ATT>GTT	p.I1118V	NID2_uc010tqs.1_Missense_Mutation_p.I1070V|NID2_uc010tqt.1_Missense_Mutation_p.I1118V|NID2_uc001wzp.2_Missense_Mutation_p.I1118V	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1118						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					AAGTAGCCAATCTGCTGGCCC	0.592											OREG0022678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	10	40										C	52481073	T	C	52481073	3	2	9	1	0	0	0	0	1	0	0	0	10415	1435	50	5	803	5	NID2	14	52481073	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08		52481073	54868467	140	2520										
LTBP2	4053	broad.mit.edu	37	chr14	74973930	74973930	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaagccaggctggcagcccaGaacacagcggtaggagccag	15	12	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:74973930G>C	uc001xqa.2	-	26	4246	c.3859C>G	c.(3859-3861)CTG>GTG	p.L1287V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1287	EGF-like 14; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		TGGCAGCCCAGAACACAGCGG	0.567													0	0	0	0.00308	0	6	57										C	74973930	G	C	74973930	3	2	9	1	0	0	0	0	1	0	0	0	9074	933	33	1	1650	1	LTBP2	14	74973930	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	22492857	74973930	32375610	141	2521										
BDKRB1	623	broad.mit.edu	37	chr14	96730151	96730151	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agagtgctgccaacatttatCatctccatctgtttcttcgg	7	11	4	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:96730151C>G	uc001yfh.2	+	3	340	c.132C>G	c.(130-132)ATC>ATG	p.I44M	BDKRB1_uc010avn.2_Missense_Mutation_p.I44M	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	44	Helical; Name=1; (Potential).				elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		CAACATTTATCATCTCCATCT	0.542													0	0	0	0.009096	0	4	51										G	96730151	C	G	96730151	3	3	9	1	0	0	0	0	1	0	0	0	1392	816	29	1	134	1	BDKRB1	14	96730151	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	21756221	96730151	10619389	142	2522										
AHNAK2	113146	broad.mit.edu	37	chr14	105408255	105408255	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcggaaggggcctgaatgcgGaggtcagtggtcttgaggtc	19	7	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:105408255G>T	uc010axc.1	-	7	13653	c.13533C>A	c.(13531-13533)CTC>CTA	p.L4511L	AHNAK2_uc001ypx.2_Silent_p.L4411L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4511						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGAATGCGGAGGTCAGTGG	0.622													1	0	1.33986e-20	0.024334	1.546e-20	27	154										T	105408255	G	T	105408255	2	4	9	1	0	0	0	0	0	0	0	1	415	1161	41	3		3	AHNAK2	14	105408255	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	8678104	105408255	1941285	143	2523										
AHNAK2	113146	broad.mit.edu	37	chr14	105408514	105408514	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccacctccatgctgggcagaGacacgtccaggttgggggac	14	13	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr14:105408514G>A	uc010axc.1	-	7	13394	c.13274C>T	c.(13273-13275)TCT>TTT	p.S4425F	AHNAK2_uc001ypx.2_Missense_Mutation_p.S4325F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4425						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTGGGCAGAGACACGTCCAG	0.622													0	0	0	0.028581	0	14	145										A	105408514	G	A	105408514	3	1	9	1	0	0	0	0	1	0	0	0	415	942	33	1	4117	1	AHNAK2	14	105408514	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	259	105408514	1941026	144	2524										
CORO2B	10391	broad.mit.edu	37	chr15	68937670	68937671	+	Missense_Mutation	DNP	GG	GG	AT													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcaccgagagcgcagggggcGgctccttcctcgtcatcccc							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:68937670_68937671GG>AT	uc002arj.3	+	2	216_217	c.187_188GG>AT	c.(187-189)GGC>ATC	p.G63I	CORO2B_uc010bic.2_Missense_Mutation_p.G58I	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	63					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CGCAGGGGGCGGCTCCTTCCTC	0.624													0	0	0	0.004672	0	4	68										AT	68937671	GG	AT	68937670	3	1	9	1	0	0	0	0	1	0	0	0	3757	1116	39	2	193	2	CORO2B	15	68937670	Missense_Mutation	DNP	GG	TCGA-BT-A20O-01A-21D-A14W-08		68937670	33593722	145	2525										
TSPAN3	10099	broad.mit.edu	37	chr15	77345133	77345133	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	actcacctcagcatagaggtCggaagggtgggccaggctgc	15	11	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:77345133C>A	uc002bcj.2	-	5	788	c.571G>T	c.(571-573)GAC>TAC	p.D191Y	TSPAN3_uc002bck.2_Missense_Mutation_p.D166Y|TSPAN3_uc010ump.1_Missense_Mutation_p.D127Y|TSPAN3_uc010bkx.2_Missense_Mutation_p.D102Y	NM_005724	NP_005715	O60637	TSN3_HUMAN	transmembrane 4 superfamily member 8 isoform 1	191	Extracellular (Potential).					integral to membrane					0				all cancers(203;1.14e-19)		GCATAGAGGTCGGAAGGGTGG	0.478													1	0	3.59834e-05	0.021553	3.90181e-05	5	25										A	77345133	C	A	77345133	3	1	9	1	0	0	0	0	1	0	0	0	16642	884	31	3	202	3	TSPAN3	15	77345133	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	8407463	77345133	25186259	146	2526										
SGK269	79834	broad.mit.edu	37	chr15	77472430	77472430	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaactccgagcataagttggCtcgtcatgaatgataattgg	11	7	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:77472430C>T	uc002bcm.2	-	3	2147	c.1839G>A	c.(1837-1839)GAG>GAA	p.E613E	SGK269_uc002bcn.2_Silent_p.E613E	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	613					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		CATAAGTTGGCTCGTCATGAA	0.348													0	0	0	0.016723	0	11	142										T	77472430	C	T	77472430	2	4	9	1	0	0	0	0	0	0	0	1	14211	796	28	2		2	SGK269	15	77472430	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	127297	77472430	25058962	147	2527										
TMC3	342125	broad.mit.edu	37	chr15	81625521	81625521	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aggttctgagtgtacatcttCgatgtgcgttgtaaatgtca	11	6	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:81625521C>T	uc002bgo.1	-	22	2542	c.2542G>A	c.(2542-2544)GAA>AAA	p.E848K	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	848	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TGTACATCTTCGATGTGCGTT	0.527													0	0	0	0.004482	0	9	93										T	81625521	C	T	81625521	3	4	9	1	0	0	0	0	1	0	0	0	15983	893	31	1	764	1	TMC3	15	81625521	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	4153091	81625521	20905871	148	2528										
DET1	55070	broad.mit.edu	37	chr15	89074506	89074506	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agtcatcagtgaagagactaCactcccggttcaggtgctca	10	11	4	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:89074506C>A	uc002bmr.2	-	2	583	c.431G>T	c.(430-432)TGT>TTT	p.C144F	DET1_uc002bmp.3_RNA|DET1_uc010bnk.2_RNA|DET1_uc002bmq.2_Missense_Mutation_p.C155F	NM_001144074	NP_001137546	Q7L5Y6	DET1_HUMAN	de-etiolated 1 isoform 2	144						nucleus				lung(1)|pancreas(1)	2	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			GAAGAGACTACACTCCCGGTT	0.537													1	0	0.000602214	0.014758	0.000630224	5	25										A	89074506	C	A	89074506	3	1	9	1	0	0	0	0	1	0	0	0	4450	478	17	4	1237	4	DET1	15	89074506	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	7448985	89074506	13456886	149	2529										
NR2F2	7026	broad.mit.edu	37	chr15	96880592	96880592	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tccagatgcctgtggtctctCtgatgtagcccatgtggaaa	11	10	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr15:96880592C>T	uc010uri.1	+	3	2210	c.986C>T	c.(985-987)TCT>TTT	p.S329F	NR2F2_uc002btp.2_Missense_Mutation_p.S196F|NR2F2_uc010urj.1_Missense_Mutation_p.S176F|NR2F2_uc010urk.1_Missense_Mutation_p.S176F	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	329	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			TGTGGTCTCTCTGATGTAGCC	0.353													0	0	0	0.021553	0	6	66										T	96880592	C	T	96880592	3	4	9	1	0	0	0	0	1	0	0	0	10628	913	32	1	1043	1	NR2F2	15	96880592	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	7806086	96880592	5650800	150	2530										
ZNF263	10127	broad.mit.edu	37	chr16	3339743	3339743	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtatgggtgtggactgcactGaaatctttggtgggaaccca	14	7	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:3339743G>T	uc002cuq.2	+	6	1569	c.1237G>T	c.(1237-1239)GAA>TAA	p.E413*	ZNF263_uc010uww.1_Nonsense_Mutation_p.E61*|ZNF263_uc002cur.2_Nonsense_Mutation_p.E61*	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	413					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						GGACTGCACTGAAATCTTTGG	0.473													1	0	3.09899e-07	0.004482	3.47189e-07	9	91										T	3339743	G	T	3339743	4	4	9	1	0	0	0	0	0	1	0	0	17800	1291	45	3	1259	3	ZNF263	16	3339743	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		3339743	87015010	151	2531										
CREBBP	1387	broad.mit.edu	37	chr16	3817750	3817750	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcggctgcgaaggagatgttGactgagaggctgtgccgtta	17	7	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:3817750G>C	uc002cvv.2	-	16	3425	c.3221C>G	c.(3220-3222)TCA>TGA	p.S1074*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.S1036*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1074					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AGGAGATGTTGACTGAGAGGC	0.428			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.013537	0	11	138										C	3817750	G	C	3817750	4	2	9	1	0	0	0	0	0	1	0	0	3861	1294	45	1	4171	1	CREBBP	16	3817750	Nonsense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	478007	3817750	86537003	152	2532										
CORO7	79585	broad.mit.edu	37	chr16	4466517	4466517	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttggacaccctgaagcggttCatggcgacgggcacggcggc	16	12	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:4466517C>T	uc002cwh.3	-	1	123	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CORO7_uc002cwf.2_Missense_Mutation_p.M1I|CORO7_uc002cwg.3_5'Flank|CORO7_uc010uxh.1_Missense_Mutation_p.M1I|CORO7_uc010uxi.1_Missense_Mutation_p.M1I|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_5'UTR|CORO7_uc010btr.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	1						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TGAAGCGGTTCATGGCGACGG	0.756													0	0	0	0.009096	0	4	23										T	4466517	C	T	4466517	3	4	9	1	0	0	0	0	1	0	0	0	3759	826	29	1	2886	1	CORO7	16	4466517	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	648767	4466517	85888236	153	2533										
SMG1	23049	broad.mit.edu	37	chr16	18859259	18859259	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	catccttattgctatcctgaGatgcaggaggacttcctccc	8	13	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:18859259G>A	uc002dfm.2	-	37	6083	c.5720C>T	c.(5719-5721)TCT>TTT	p.S1907F	SMG1_uc010bwb.2_Missense_Mutation_p.S1767F|SMG1_uc010bwa.2_Missense_Mutation_p.S638F|SMG1_uc002dfo.3_Missense_Mutation_p.S205F	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1907	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GCTATCCTGAGATGCAGGAGG	0.398													0	0	0	0.016723	0	13	63										A	18859259	G	A	18859259	3	1	9	1	0	0	0	0	1	0	0	0	14795	942	33	1	5373	1	SMG1	16	18859259	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	14392742	18859259	71495494	154	2534										
DNAH3	55567	broad.mit.edu	37	chr16	20997001	20997001	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaggcttcgaatgttatcatCgactatctttccagtgggtg	11	8	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:20997001C>G	uc010vbe.1	-	48	7063	c.7063G>C	c.(7063-7065)GAT>CAT	p.D2355H	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2355					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATGTTATCATCGACTATCTTT	0.458													0	0	0	0.010729	0	11	108										G	20997001	C	G	20997001	3	3	9	1	0	0	0	0	1	0	0	0	4603	884	31	1	5346	1	DNAH3	16	20997001	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	2137742	20997001	69357752	155	2535										
THAP11	57215	broad.mit.edu	37	chr16	67876802	67876802	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cagcagcagcagcaacagcaGcaacagcagcagcagcagca	11	14	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:67876802G>A	uc002euo.2	+	1	590	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	115	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		agcaacagcagcaacagcagc	0.303													0	0	0	0.004672	0	3	64										A	67876802	G	A	67876802	2	1	9	1	0	0	0	0	0	0	0	1	15840	962	34	2		2	THAP11	16	67876802	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	46879801	67876802	22477951	156	2536										
SLC12A4	6560	broad.mit.edu	37	chr16	67979985	67979985	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	catccggcacttcctccagaCctgaggcaagggaccaggtg	12	14	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:67979985C>G	uc002euz.2	-	20	2749	c.2608G>C	c.(2608-2610)GTC>CTC	p.V870L	LCAT_uc002euy.1_5'Flank|SLC12A4_uc010ceu.2_Missense_Mutation_p.V864L|SLC12A4_uc010vkh.1_Missense_Mutation_p.V839L|SLC12A4_uc010vki.1_Missense_Mutation_p.V870L|SLC12A4_uc010vkj.1_Missense_Mutation_p.V872L|SLC12A4_uc002eva.2_Missense_Mutation_p.V870L|SLC12A4_uc010cev.1_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	870	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTCCTCCAGACCTGAGGCAAG	0.592													0	0	0	0.004672	0	3	39										G	67979985	C	G	67979985	3	3	9	1	0	0	0	0	1	0	0	0	14385	521	18	4	669	4	SLC12A4	16	67979985	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	103183	67979985	22374768	157	2537										
ZFHX3	463	broad.mit.edu	37	chr16	72992721	72992721	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtcgcccacttcctgcttctCtccttctgccgccccagagt	7	19	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr16:72992721C>T	uc002fck.2	-	2	1997	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	442					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TCCTGCTTCTCTCCTTCTGCC	0.463													0	0	0	0.028581	0	13	111										T	72992721	C	T	72992721	3	4	9	1	0	0	0	0	1	0	0	0	17631	922	32	1	9823	1	ZFHX3	16	72992721	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	5012736	72992721	17362032	158	2538										
FAM57A	79850	broad.mit.edu	37	chr17	641131	641131	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tggtttctgattccatacatGatctatgactcgtacgccat	7	10	2	3	rs143392294	byFrequency	TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:641131G>A	uc002frp.2	+	3	293	c.252G>A	c.(250-252)ATG>ATA	p.M84I	FAM57A_uc002frq.2_Missense_Mutation_p.M84I|FAM57A_uc002frr.2_5'UTR	NM_024792	NP_079068	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	84	TLC.|Helical; (Potential).					integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		TTCCATACATGATCTATGACT	0.483													0	0	0	0.020292	0	14	155										A	641131	G	A	641131	3	1	9	1	0	0	0	0	1	0	0	0	5588	1290	45	1	262	1	FAM57A	17	641131	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		641131	80554079	159	2539										
ZZEF1	23140	broad.mit.edu	37	chr17	4015972	4015972	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	attgctggggatgtgcacatCtcggacttcctgaagatcgc	12	10	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:4015972C>G	uc002fxe.2	-	5	1061	c.997G>C	c.(997-999)GAT>CAT	p.D333H	ZZEF1_uc002fxk.1_Missense_Mutation_p.D333H	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	333	DOC.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATGTGCACATCTCGGACTTCC	0.542													0	0	0	0.009096	0	4	34										G	4015972	C	G	4015972	3	3	9	1	0	0	0	0	1	0	0	0	18252	913	32	1	8092	1	ZZEF1	17	4015972	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3374841	4015972	77179238	160	2540										
C17orf81	23587	broad.mit.edu	37	chr17	7162203	7162203	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gtccaagaaagagagagaagCcagagatagcctgatcctgc	12	9	0	5			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:7162203C>T	uc002gfg.1	+	8	901	c.794C>T	c.(793-795)GCC>GTC	p.A265V	C17orf81_uc002gfj.2_3'UTR|C17orf81_uc010cmb.2_3'UTR|C17orf81_uc002gfh.1_Missense_Mutation_p.A265V|C17orf81_uc002gfi.1_Missense_Mutation_p.A265V|C17orf81_uc002gfl.1_Intron	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						GAGAGAGAAGCCAGAGATAGC	0.517													0	0	0	0.008291	0	10	55										T	7162203	C	T	7162203	3	4	9	1	0	0	0	0	1	0	0	0	1886	739	26	2	925	2	C17orf81	17	7162203	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3146231	7162203	74033007	161	2541										
TP53	7157	broad.mit.edu	37	chr17	7577103	7577103	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctctgtgcgccggtctctccCaggacaggcacaaacacgca	10	16	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:7577103C>G	uc002gim.2	-	8	1029	c.835G>C	c.(835-837)GGG>CGG	p.G279R	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G279R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G147R|TP53_uc010cng.1_Missense_Mutation_p.G147R|TP53_uc002gii.1_Missense_Mutation_p.G147R|TP53_uc010cnh.1_Missense_Mutation_p.G279R|TP53_uc010cni.1_Missense_Mutation_p.G279R|TP53_uc002gij.2_Missense_Mutation_p.G279R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	279	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> E (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|G -> W (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G279E(31)|p.G279R(7)|p.0?(7)|p.R280fs*65(6)|p.G279V(4)|p.G279G(3)|p.G279W(2)|p.?(2)|p.G279fs*65(2)|p.G279fs*27(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.G279fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTCTCTCCCAGGACAGGCA	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.004672	0	3	30										G	7577103	C	G	7577103	3	3	9	1	0	0	0	0	1	0	0	0	16378	594	21	4	451	4	TP53	17	7577103	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	414900	7577103	73618107	162	2542										
KRBA2	124751	broad.mit.edu	37	chr17	8273001	8273001	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccaagaattgtgaaaatatcTaacaagacactgaccacctc	5	11	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:8273001T>C	uc002glf.1	-	2	936	c.930A>G	c.(928-930)TTA>TTG	p.L310L	KRBA2_uc002glg.1_Silent_p.L227L	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	310	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						TGAAAATATCTAACAAGACAC	0.418													0	0	0	0.021553	0	6	44										C	8273001	T	C	8273001	2	2	9	1	0	0	0	0	0	0	0	1	8440	1519	53	5		5	KRBA2	17	8273001	Silent	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	695898	8273001	72922209	163	2543										
ATPAF2	91647	broad.mit.edu	37	chr17	17921970	17921970	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcctgcagctcatagtcatGggcccactcaatgttgcccc	8	16	3	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:17921970G>A	uc002gse.1	-	8	916	c.763C>T	c.(763-765)CAT>TAT	p.H255Y	ATPAF2_uc002gsd.1_Intron|ATPAF2_uc002gsf.1_RNA	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	255					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)					TCATAGTCATGGGCCCACTCA	0.607													0	0	0	0.006214	0	7	114										A	17921970	G	A	17921970	3	1	9	1	0	0	0	0	1	0	0	0	1201	1348	47	2	110	2	ATPAF2	17	17921970	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	9648969	17921970	63273240	164	2544										
GIT1	28964	broad.mit.edu	37	chr17	27909741	27909741	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgaggtctttggcggtgactCcatcatcgtcccggcaggga	14	11	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:27909741C>T	uc002hef.2	-	4	594	c.380G>A	c.(379-381)GGA>GAA	p.G127E	GIT1_uc002heg.2_Missense_Mutation_p.G127E|GIT1_uc010wbg.1_Missense_Mutation_p.G127E|GIT1_uc010csb.1_Missense_Mutation_p.G127E	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	127					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GGCGGTGACTCCATCATCGTC	0.577													0	0	0	0.004672	0	3	30										T	27909741	C	T	27909741	3	4	9	1	0	0	0	0	1	0	0	0	6396	855	30	1	2004	1	GIT1	17	27909741	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	9987771	27909741	53285469	165	2545										
STH	246744	broad.mit.edu	37	chr17	44076786	44076786	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	caggttgccagagacagaacCctcagcttagcatgggaagt	12	10	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:44076786C>A	uc002ijy.2	+	1	171	c.141C>A	c.(139-141)ACC>ACA	p.T47T	MAPT_uc010dau.2_Intron|MAPT_uc002ijr.3_Intron|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_001007532	NP_001007533	Q8IWL8	STH_HUMAN	saitohin	47						cytoplasm|nucleus					0						GAGACAGAACCCTCAGCTTAG	0.413													1	0	0.000602214	0.014758	0.000630224	5	42										A	44076786	C	A	44076786	2	1	9	1	0	0	0	0	0	0	0	1	15280	610	22	4		4	STH	17	44076786	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	16167045	44076786	37118424	166	2546										
SP2	6668	broad.mit.edu	37	chr17	46000404	46000404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cccagcaacagctgcagccaCctctaacaccacctgtagca	6	18	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:46000404C>T	uc002imk.2	+	4	1273	c.1136C>T	c.(1135-1137)ACC>ATC	p.T379I	SP2_uc002iml.2_Missense_Mutation_p.T372I	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	379					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0						GCTGCAGCCACCTCTAACACC	0.587													0	0	0	0.016723	0	13	69										T	46000404	C	T	46000404	3	4	9	1	0	0	0	0	1	0	0	0	14964	507	18	2	1150	2	SP2	17	46000404	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1923618	46000404	35194806	167	2547										
DLX3	1747	broad.mit.edu	37	chr17	48072068	48072068	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggctggcagcggctgctcccGatacgccccgtattgccggt	14	15	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:48072068G>A	uc002ipy.2	-	1	521	c.295C>T	c.(295-297)CGG>TGG	p.R99W		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	99						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCTGCTCCCGATACGCCCCG	0.627													0	0	0	0.004482	0	8	29										A	48072068	G	A	48072068	3	1	9	1	0	0	0	0	1	0	0	0	4572	1057	37	1	580	1	DLX3	17	48072068	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	2071664	48072068	33123142	168	2548										
BRIP1	83990	broad.mit.edu	37	chr17	59934548	59934548	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcatgcacaacaacatgacaAttgtacttcagctttttcac	5	11	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:59934548A>T	uc002izk.1	-	4	391	c.250T>A	c.(250-252)TTG>ATG	p.L84M		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	84	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CAACATGACAATTGTACTTCA	0.343			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.016723	0	13	72										T	59934548	A	T	59934548	3	4	9	1	0	0	0	0	1	0	0	0	1514	98	4	5	3567	5	BRIP1	17	59934548	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	11862480	59934548	21260662	169	2549										
KCNH6	81033	broad.mit.edu	37	chr17	61623123	61623123	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggccacccctagcctcacctCtacatcccctggaagtacaa	6	18	2	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:61623123C>G	uc002jay.2	+	14	2925	c.2845C>G	c.(2845-2847)CTA>GTA	p.L949V	KCNH6_uc010wpl.1_Missense_Mutation_p.L790V|KCNH6_uc010wpm.1_Missense_Mutation_p.L913V|KCNH6_uc002jaz.1_Missense_Mutation_p.L860V	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	949	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGCCTCACCTCTACATCCCCT	0.587													0	0	0	0.004482	0	9	99										G	61623123	C	G	61623123	3	3	9	1	0	0	0	0	1	0	0	0	8036	912	32	1	2899	1	KCNH6	17	61623123	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1688575	61623123	19572087	170	2550										
FTSJ3	117246	broad.mit.edu	37	chr17	61897650	61897650	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agccttagcctcagccacctTcttgatgggacgtgcattga	10	12	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:61897650T>C	uc002jbz.2	-	18	2299	c.2221A>G	c.(2221-2223)AAG>GAG	p.K741E	FTSJ3_uc002jca.2_Missense_Mutation_p.K741E	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	741					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						TCAGCCACCTTCTTGATGGGA	0.562													0	0	0	0.004482	0	8	105										C	61897650	T	C	61897650	3	2	9	1	0	0	0	0	1	0	0	0	6089	1792	62	5	334	5	FTSJ3	17	61897650	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	274527	61897650	19297560	171	2551										
ABCA8	10351	broad.mit.edu	37	chr17	66937049	66937049	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agaaaaatcatttacttgatGactatgaggatatatataca	6	4	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:66937049G>A	uc002jhp.2	-	3	330	c.151C>T	c.(151-153)CAT>TAT	p.H51Y	ABCA8_uc002jhq.2_Missense_Mutation_p.H51Y|ABCA8_uc010wqq.1_Missense_Mutation_p.H51Y|ABCA8_uc010wqr.1_5'UTR|ABCA8_uc002jhr.2_Missense_Mutation_p.H51Y|ABCA8_uc002jhs.2_Missense_Mutation_p.H51Y|ABCA8_uc002jht.2_Missense_Mutation_p.H51Y	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	51						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTTACTTGATGACTATGAGGA	0.323													0	0	0	0.004672	0	3	30										A	66937049	G	A	66937049	3	1	9	1	0	0	0	0	1	0	0	0	38	1290	45	1	4738	1	ABCA8	17	66937049	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	5039399	66937049	14258161	172	2552										
ABCA9	10350	broad.mit.edu	37	chr17	67045523	67045523	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	attagtatcattaaaactatCtacacgtcccagatccattg	4	10	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:67045523C>T	uc002jhu.2	-	3	348	c.205G>A	c.(205-207)GAT>AAT	p.D69N	ABCA9_uc010dez.2_Missense_Mutation_p.D69N|ABCA9_uc002jhv.2_Missense_Mutation_p.D69N	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	69					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TTAAAACTATCTACACGTCCC	0.363													0	0	0	0.020292	0	14	85										T	67045523	C	T	67045523	3	4	9	1	0	0	0	0	1	0	0	0	39	913	32	1	4817	1	ABCA9	17	67045523	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	108474	67045523	14149687	173	2553										
ABCA10	10349	broad.mit.edu	37	chr17	67183864	67183864	+	Frame_Shift_Del	DEL	C	C	-													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cacgccttaactttaagaagCgaagtgttgccactgcatag							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:67183864delC	uc010dfa.1	-	20	3167	c.2288delG	c.(2287-2289)CGCfs	p.R763fs	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Frame_Shift_Del_p.R364fs	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	763					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CTTTAAGAAGCGAAGTGTTGC	0.378																		7	118	---	---								-	67183864	C	-	67183864	7	5	9	1	0	1	0	1	0	0	0	0	29	768	27	0	2427	0	ABCA10	17	67183864	Frame_Shift_Del	DEL	C	TCGA-BT-A20O-01A-21D-A14W-08	138341	67183864	14011346	174	2554										
ABCA10	10349	broad.mit.edu	37	chr17	67189995	67189995	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gctgaatcccttttattttaGcaaataccctgaggttttct	6	9	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:67189995G>T	uc010dfa.1	-	14	2360	c.1481C>A	c.(1480-1482)GCT>GAT	p.A494D	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.A95D	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	494	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTTTATTTTAGCAAATACCCT	0.328													1	0	9.70103e-10	0.008291	1.10054e-09	9	101										T	67189995	G	T	67189995	3	4	9	1	0	0	0	0	1	0	0	0	29	971	34	4	3258	4	ABCA10	17	67189995	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	6131	67189995	14005215	175	2555										
FOXK2	3607	broad.mit.edu	37	chr17	80529635	80529635	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccttactcctacgcgcagctGatagttcaggcgattacgat	9	12	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr17:80529635G>C	uc002kfn.2	+	4	969	c.798G>C	c.(796-798)CTG>CTC	p.L266L	FOXK2_uc002kfm.1_Silent_p.L266L|FOXK2_uc010diu.2_Silent_p.L266L	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	266	Fork-head.				embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			ACGCGCAGCTGATAGTTCAGG	0.398													0	0	0	0.00308	0	7	52										C	80529635	G	C	80529635	2	2	9	1	0	0	0	0	0	0	0	1	6015	1277	45	1		1	FOXK2	17	80529635	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	13339640	80529635	665575	176	2556										
KIAA1012	22878	broad.mit.edu	37	chr18	29511315	29511315	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgatgttaaggtcataatctCctgctgtaatcacattagct	7	8	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr18:29511315C>T	uc002kxc.3	-	2	693	c.329G>A	c.(328-330)GGA>GAA	p.G110E	KIAA1012_uc002kxb.3_Missense_Mutation_p.G56E|KIAA1012_uc002kxd.3_RNA|KIAA1012_uc002kxe.2_Missense_Mutation_p.G110E	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	110					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						GTCATAATCTCCTGCTGTAAT	0.408													0	0	0	0.010729	0	10	94										T	29511315	C	T	29511315	3	4	9	1	0	0	0	0	1	0	0	0	8204	855	30	1	4090	1	KIAA1012	18	29511315	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		29511315	48565933	177	2557										
RIT2	6014	broad.mit.edu	37	chr18	40323522	40323522	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcttccacaggctgtcttttCtcttcagtttcttttccatc	4	13	5	0	rs77976328		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr18:40323522C>G	uc002lav.2	-	5	763	c.590G>C	c.(589-591)AGA>ACA	p.R197T	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	197					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						GCTGTCTTTTCTCTTCAGTTT	0.413													0	0	0	0.021523	0	23	152										G	40323522	C	G	40323522	3	3	9	1	0	0	0	0	1	0	0	0	13387	913	32	1	67	1	RIT2	18	40323522	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	10812207	40323522	37753726	178	2558										
TMEM146	257062	broad.mit.edu	37	chr19	5772930	5772930	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctcccagccgcagaactggaCcaccatgataaaggaattcg	9	13	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:5772930C>A	uc002mda.2	+	20	1956	c.1895C>A	c.(1894-1896)ACC>AAC	p.T632N		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	632	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAGAACTGGACCACCATGATA	0.567													1	0	0.00024832	0.009096	0.000262927	3	40										A	5772930	C	A	5772930	3	1	9	1	0	0	0	0	1	0	0	0	16057	507	18	4	1973	4	TMEM146	19	5772930	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08		5772930	53356053	179	2559										
MYO9B	4650	broad.mit.edu	37	chr19	17263473	17263473	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gagctgtcgtcgagaaatatCtgcttgaaaagtctcgcctg	11	9	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:17263473C>G	uc010eak.2	+	4	1107	c.955C>G	c.(955-957)CTG>GTG	p.L319V	MYO9B_uc002nfi.2_Missense_Mutation_p.L319V|MYO9B_uc002nfj.1_Missense_Mutation_p.L319V	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	319	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CGAGAAATATCTGCTTGAAAA	0.368													0	0	0	0.021553	0	4	35										G	17263473	C	G	17263473	3	3	9	1	0	0	0	0	1	0	0	0	10085	912	32	1	965	1	MYO9B	19	17263473	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	11490543	17263473	41865510	180	2560										
ZNF536	9745	broad.mit.edu	37	chr19	31039753	31039753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cagctctctagactctgcttCtgagaagatggcccaaggtc	10	12	3	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:31039753C>G	uc002nsu.1	+	4	3365	c.3227C>G	c.(3226-3228)TCT>TGT	p.S1076C	ZNF536_uc010edd.1_Missense_Mutation_p.S1076C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1076					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GACTCTGCTTCTGAGAAGATG	0.552													0	0	0	0.00308	0	8	61										G	31039753	C	G	31039753	3	3	9	1	0	0	0	0	1	0	0	0	17971	913	32	1	3237	1	ZNF536	19	31039753	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	13776280	31039753	28089230	181	2561										
KIAA0355	9710	broad.mit.edu	37	chr19	34832940	34832940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgcctgtgccccctccaccaCgggcaccccaggctggggca	12	19	0	0	rs144261536		TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:34832940C>T	uc002nvd.3	+	10	2960	c.2101C>T	c.(2101-2103)CGG>TGG	p.R701W		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	701										ovary(1)	1	Esophageal squamous(110;0.162)					CCCTCCACCACGGGCACCCCA	0.612													0	0	0	0.004482	0	8	94										T	34832940	C	T	34832940	3	4	9	1	0	0	0	0	1	0	0	0	8170	527	19	2	2135	2	KIAA0355	19	34832940	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3793187	34832940	24296043	182	2562										
CIC	23152	broad.mit.edu	37	chr19	42793047	42793047	+	Silent	SNP	T	T	C													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctctactttacagtgtcctcTgagctcctgtccgttgcagc							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:42793047T>C	uc002otf.1	+	7	979	c.939T>C	c.(937-939)TCT>TCC	p.S313S		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CAGTGTCCTCTGAGCTCCTGT	0.562			T	DUX4	soft tissue sarcoma								0	0	0	0.028581	0	5	42										C	42793047	T	C	42793047	2	2	9	1	0	0	0	0	0	0	0	1	3424	1567	55	5		5	CIC	19	42793047	Silent	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	7960107	42793047	16335936	183	2563	16	2								
CIC	23152	broad.mit.edu	37	chr19	42793049	42793049	+	Missense_Mutation	SNP	A	A	T													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctactttacagtgtcctctgAgctcctgtccgttgcagccc							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:42793049A>T	uc002otf.1	+	7	981	c.941A>T	c.(940-942)GAG>GTG	p.E314V		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GTGTCCTCTGAGCTCCTGTCC	0.557			T	DUX4	soft tissue sarcoma								0	0	0	0.024245	0	4	44										T	42793049	A	T	42793049	3	4	9	1	0	0	0	0	1	0	0	0	3424	304	11	5	967	5	CIC	19	42793049	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	2	42793049	16335934	184	2564	16	2								
XRCC1	7515	broad.mit.edu	37	chr19	44079154	44079154	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aagattttctgcacagtgagTctggaaacaacagtgggaga	12	6	2	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:44079154T>C	uc002owt.2	-	2	172	c.52A>G	c.(52-54)ACT>GCT	p.T18A	XRCC1_uc010xwp.1_Intron|uc010xwq.1_5'Flank	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	18					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				GCACAGTGAGTCTGGAAACAA	0.527								Other_BER_factors					0	0	0	0.021553	0	6	26										C	44079154	T	C	44079154	3	2	9	1	0	0	0	0	1	0	0	0	17449	1681	58	5	1913	5	XRCC1	19	44079154	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	1286105	44079154	15049829	185	2565										
ZNF283	284349	broad.mit.edu	37	chr19	44352248	44352249	+	Missense_Mutation	DNP	GG	GG	TC													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcggaaagaccttttgtagtGggtatcaacttactcgacat							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:44352248_44352249GG>TC	uc002oxr.3	+	7	1763_1764	c.1495_1496GG>TC	c.(1495-1497)GGG>TCG	p.G499S	ZNF283_uc002oxp.3_Missense_Mutation_p.G360S	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	499	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CTTTTGTAGTGGGTATCAACTT	0.411													0	0	0	0.004672	0	21	101										TC	44352249	GG	TC	44352248	3	4	9	1	0	0	0	0	1	0	0	0	17817	1348	47	4	1509	4	ZNF283	19	44352248	Missense_Mutation	DNP	GG	TCGA-BT-A20O-01A-21D-A14W-08	273094	44352248	14776735	186	2566										
ERCC2	2068	broad.mit.edu	37	chr19	45855835	45855835	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acccacacactgggccgcgtGgcgcatggcatcgaaggtaa	13	13	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:45855835G>A	uc002pbj.2	-	21	2022	c.1975C>T	c.(1975-1977)CAC>TAC	p.H659Y	ERCC2_uc002pbh.2_Missense_Mutation_p.H222Y|ERCC2_uc002pbi.2_Missense_Mutation_p.H352Y|ERCC2_uc010ejz.2_Missense_Mutation_p.H581Y|ERCC2_uc002pbk.2_Missense_Mutation_p.H635Y	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	659					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGGCCGCGTGGCGCATGGCA	0.612			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.006122	0	19	57										A	45855835	G	A	45855835	3	1	9	1	0	0	0	0	1	0	0	0	5213	1348	47	2	319	2	ERCC2	19	45855835	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1503587	45855835	13273148	187	2567										
PTGIR	5739	broad.mit.edu	37	chr19	47124901	47124901	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccatctcactgctgctgtcaGgggcgacagcctgggtgaag	14	12	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:47124901G>C	uc002pex.2	-	3	910	c.797C>G	c.(796-798)CCT>CGT	p.P266R		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	266	Extracellular (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	GCTGCTGTCAGGGGCGACAGC	0.642													0	0	0	0.008291	0	10	32										C	47124901	G	C	47124901	3	2	9	1	0	0	0	0	1	0	0	0	12751	1000	35	4	367	4	PTGIR	19	47124901	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1269066	47124901	12004082	188	2568										
ALDH16A1	126133	broad.mit.edu	37	chr19	49967904	49967904	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cacaggggctgtatgagtatCtgcggccctcagggacccct	13	13	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:49967904C>T	uc002pnt.2	+	12	1569	c.1453C>T	c.(1453-1455)CTG>TTG	p.L485L	ALDH16A1_uc010yar.1_Silent_p.L434L|ALDH16A1_uc010yas.1_Silent_p.L320L|ALDH16A1_uc010yat.1_Silent_p.L322L	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	485							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GTATGAGTATCTGCGGCCCTC	0.662													0	0	0	0.004482	0	9	137										T	49967904	C	T	49967904	2	4	9	1	0	0	0	0	0	0	0	1	488	912	32	1		1	ALDH16A1	19	49967904	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	2843003	49967904	9161079	189	2569										
ZNF468	90333	broad.mit.edu	37	chr19	53352431	53352431	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	catttccactcctcctgagaGaattctatggccacgtccct	6	15	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:53352431G>A	uc002qaf.2	-	3	202	c.51C>T	c.(49-51)TTC>TTT	p.F17F	ZNF468_uc002qae.2_5'UTR	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		CCTCCTGAGAGAATTCTATGG	0.443													0	0	0	0.00308	0	7	158										A	53352431	G	A	53352431	2	1	9	1	0	0	0	0	0	0	0	1	17925	933	33	1		1	ZNF468	19	53352431	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	3384527	53352431	5776552	190	2570										
ZNF160	90338	broad.mit.edu	37	chr19	53573254	53573254	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agcttactccaagctgattgTtcataagcttgttttctatg	7	8	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:53573254T>C	uc010eqk.2	-	7	949	c.533A>G	c.(532-534)AAC>AGC	p.N178S	ZNF160_uc002qaq.3_Missense_Mutation_p.N178S|ZNF160_uc002qar.3_Missense_Mutation_p.N178S	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	178					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AAGCTGATTGTTCATAAGCTT	0.413													0	0	0	0.021553	0	5	146										C	53573254	T	C	53573254	3	2	9	1	0	0	0	0	1	0	0	0	17736	1725	60	5	1927	5	ZNF160	19	53573254	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	220823	53573254	5555729	191	2571										
CACNG6	59285	broad.mit.edu	37	chr19	54502980	54502980	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcatggtgctcagtaaaggtGcagagttcctgctccgagtt	12	9	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:54502980G>A	uc002qct.2	+	3	1089	c.499G>A	c.(499-501)GCA>ACA	p.A167T	CACNG6_uc002qcu.2_Intron|CACNG6_uc002qcv.2_Intron	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	167						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CAGTAAAGGTGCAGAGTTCCT	0.592													0	0	0	0.021553	0	6	178										A	54502980	G	A	54502980	3	1	9	1	0	0	0	0	1	0	0	0	2561	1319	46	2	509	2	CACNG6	19	54502980	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	929726	54502980	4626003	192	2572										
PRPF31	26121	broad.mit.edu	37	chr19	54632680	54632681	+	Missense_Mutation	DNP	GG	GG	CC													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	agcagagcgtcgtatatggcGggaagtccaccatccgcgac							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:54632680_54632681GG>CC	uc002qdh.2	+	13	1705_1706	c.1309_1310GG>CC	c.(1309-1311)GGG>CCG	p.G437P	PRPF31_uc010yek.1_Missense_Mutation_p.R414P	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	437					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CGTATATGGCGGGAAGTCCACC	0.619											OREG0003636	type=REGULATORY REGION|Gene=AK091105|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004672	0	3	11										CC	54632681	GG	CC	54632680	3	2	9	1	0	0	0	0	1	0	0	0	12566	1116	39	4	1355	4	PRPF31	19	54632680	Missense_Mutation	DNP	GG	TCGA-BT-A20O-01A-21D-A14W-08	129700	54632680	4496303	193	2573										
PTPRH	5794	broad.mit.edu	37	chr19	55696892	55696892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcagtgcacaatgggtgggcCtccctccatggtctgatcca	12	13	1	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:55696892C>T	uc002qjq.2	-	18	3113	c.3040G>A	c.(3040-3042)GGC>AGC	p.G1014S	PTPRH_uc010esv.2_Missense_Mutation_p.G836S	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1014	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		ATGGGTGGGCCTCCCTCCATG	0.632													0	0	0	0.004672	0	3	18										T	55696892	C	T	55696892	3	4	9	1	0	0	0	0	1	0	0	0	12803	681	24	2	319	2	PTPRH	19	55696892	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	1064212	55696892	3432091	194	2574										
HSPBP1	23640	broad.mit.edu	37	chr19	55776711	55776711	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gagctcctccaggcccagttCcggctcccgacactcgcgca	10	19	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr19:55776711C>A	uc002qjx.2	-	6	1188	c.1078G>T	c.(1078-1080)GAA>TAA	p.E360*	HSPBP1_uc002qjy.2_Nonsense_Mutation_p.E314*|HSPBP1_uc002qkb.2_Missense_Mutation_p.G310V|HSPBP1_uc002qka.2_Nonsense_Mutation_p.E314*|HSPBP1_uc002qkd.2_Nonsense_Mutation_p.E314*|HSPBP1_uc002qkc.2_Nonsense_Mutation_p.E314*|uc002qke.2_5'Flank	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	317					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		AGGCCCAGTTCCGGCTCCCGA	0.647													1	0	0.000157383	0.00308	0.000167958	7	93										A	55776711	C	A	55776711	4	1	9	1	0	0	0	0	0	1	0	0	7426	864	30	3	147	3	HSPBP1	19	55776711	Nonsense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	79819	55776711	3352272	195	2575										
PDYN	5173	broad.mit.edu	37	chr20	1961214	1961214	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gcgcaaaaagcccccatagcGtttgacctgctccttggggt	11	13	0	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:1961214G>A	uc010gaj.2	-	3	762	c.520C>T	c.(520-522)CGC>TGC	p.R174C	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.R174C|PDYN_uc010zpt.1_Missense_Mutation_p.R19C	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	174					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						CCCCCATAGCGTTTGACCTGC	0.582													0	0	0	0.021553	0	6	81										A	1961214	G	A	1961214	3	1	9	1	0	0	0	0	1	0	0	0	11699	1145	40	2	248	2	PDYN	20	1961214	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		1961214	61064306	196	2576										
ZHX3	23051	broad.mit.edu	37	chr20	39832810	39832810	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggcccgttggcggcatggggGttttttgcagagctggcaga	18	8	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:39832810G>T	uc002xjs.1	-	3	1125	c.747C>A	c.(745-747)AAC>AAA	p.N249K	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.N249K|ZHX3_uc002xjt.1_Missense_Mutation_p.N249K|ZHX3_uc002xju.1_Missense_Mutation_p.N249K|ZHX3_uc002xjv.1_Missense_Mutation_p.N249K|ZHX3_uc002xjw.1_Missense_Mutation_p.N249K|ZHX3_uc010ggg.1_Missense_Mutation_p.N249K	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	249	Required for homodimerization and interaction with NFYA.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CGGCATGGGGGTTTTTTGCAG	0.587													1	0	0.00116845	0.021553	0.00121807	6	68										T	39832810	G	T	39832810	3	4	9	1	0	0	0	0	1	0	0	0	17674	1252	44	4	2131	4	ZHX3	20	39832810	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	37871596	39832810	23192710	197	2577										
TSHZ2	128553	broad.mit.edu	37	chr20	51870547	51870547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tgcagcagaacttgccttctCggtccgtctcgaaacccagc	9	15	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr20:51870547C>T	uc002xwo.2	+	2	1506	c.550C>T	c.(550-552)CGG>TGG	p.R184W		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	184					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CTTGCCTTCTCGGTCCGTCTC	0.552													0	0	0	0.009096	0	4	41										T	51870547	C	T	51870547	3	4	9	1	0	0	0	0	1	0	0	0	16621	875	31	1	556	1	TSHZ2	20	51870547	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	12037737	51870547	11154973	198	2578										
IL10RB	3588	broad.mit.edu	37	chr21	34648997	34648997	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gaccacaccttgagagtcagGgctgaatttgcagatgagca	12	9	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr21:34648997G>A	uc002yrk.1	+	3	369	c.270G>A	c.(268-270)AGG>AGA	p.R90R	IL10RB_uc002yrh.1_Silent_p.R160R|IL10RB_uc002yri.1_Silent_p.R43R|IL10RB_uc002yrl.1_Silent_p.R92R	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	90	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						TGAGAGTCAGGGCTGAATTTG	0.398													0	0	0	0.010729	0	11	148										A	34648997	G	A	34648997	2	1	9	1	0	0	0	0	0	0	0	1	7621	1223	43	2		2	IL10RB	21	34648997	Silent	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		34648997	13480898	199	2579										
KCNJ15	3772	broad.mit.edu	37	chr21	39671406	39671406	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccctgttcgctgccacttttGtgatgacctggttccttttt	8	12	0	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr21:39671406G>A	uc002ywv.2	+	4	525	c.223G>A	c.(223-225)GTG>ATG	p.V75M	KCNJ15_uc002yww.2_Missense_Mutation_p.V75M|KCNJ15_uc002ywx.2_Missense_Mutation_p.V75M	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	75	Helical; Name=M1; (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						TGCCACTTTTGTGATGACCTG	0.473													0	0	0	0.00308	0	7	88										A	39671406	G	A	39671406	3	1	9	1	0	0	0	0	1	0	0	0	8049	1377	48	2	225	2	KCNJ15	21	39671406	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	5022409	39671406	8458489	200	2580										
ERG	2078	broad.mit.edu	37	chr21	39755633	39755633	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cttcccatggaccttggtcaTgatgttcttgtcatagtagt	9	9	3	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr21:39755633T>C	uc010gnw.2	-	12	1448	c.1153A>G	c.(1153-1155)ATG>GTG	p.M385V	ERG_uc002yxa.2_Missense_Mutation_p.M378V|ERG_uc011aek.1_Missense_Mutation_p.M286V|ERG_uc010gnv.2_Missense_Mutation_p.M262V|ERG_uc010gnx.2_Missense_Mutation_p.M361V|ERG_uc011ael.1_Missense_Mutation_p.M385V|ERG_uc002yxb.2_Missense_Mutation_p.M361V	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	385	ETS.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				ACCTTGGTCATGATGTTCTTG	0.592													0	0	0	0.008291	0	10	85										C	39755633	T	C	39755633	3	2	9	1	0	0	0	0	1	0	0	0	5222	1464	51	5	311	5	ERG	21	39755633	Missense_Mutation	SNP	T	TCGA-BT-A20O-01A-21D-A14W-08	84227	39755633	8374262	201	2581										
GAB4	128954	broad.mit.edu	37	chr22	17447085	17447085	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tagaaagctctgtgagtgggGagccaagcaggtcaaagcga	15	7	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:17447085G>C	uc002zlw.2	-	6	1301	c.1193C>G	c.(1192-1194)TCC>TGC	p.S398C	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	398										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGTGAGTGGGGAGCCAAGCAG	0.592													0	0	0	0.00308	0	8	57										C	17447085	G	C	17447085	3	2	9	1	0	0	0	0	1	0	0	0	6151	1174	41	1	551	1	GAB4	22	17447085	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		17447085	33857481	202	2582										
ZNF74	7625	broad.mit.edu	37	chr22	20749694	20749694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tatcgggttggggtcttcccGaagccaggtccaaggtgagt	15	9	1	1	rs139227842	by1000genomes	TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:20749694G>A	uc010gsm.2	+	3	318	c.106G>A	c.(106-108)GAA>AAA	p.E36K	ZNF74_uc002zsg.2_5'UTR|ZNF74_uc002zsh.2_Missense_Mutation_p.E36K|ZNF74_uc002zsi.2_Intron|ZNF74_uc010gsn.2_5'UTR	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	36					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GGGTCTTCCCGAAGCCAGGTC	0.532													0	0	0	0.009096	0	4	57										A	20749694	G	A	20749694	3	1	9	1	0	0	0	0	1	0	0	0	18124	1059	37	1	112	1	ZNF74	22	20749694	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	3302609	20749694	30554872	203	2583										
EWSR1	2130	broad.mit.edu	37	chr22	29695597	29695597	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ttctcaccttaggtggtgatCgtggcagaggtggccctggt	15	9	1	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:29695597C>T	uc003aet.2	+	16	2015	c.1687C>T	c.(1687-1689)CGT>TGT	p.R563C	EWSR1_uc003aev.2_Missense_Mutation_p.R568C|EWSR1_uc003aew.2_Missense_Mutation_p.R507C|EWSR1_uc003aex.2_Missense_Mutation_p.R562C|EWSR1_uc003aey.2_Missense_Mutation_p.R358C|EWSR1_uc003aez.2_Missense_Mutation_p.R224C	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	563	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254						AGGTGGTGATCGTGGCAGAGG	0.607			T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								0	0	0	0.014758	0	3	33										T	29695597	C	T	29695597	3	4	9	1	0	0	0	0	1	0	0	0	5296	884	31	1	1866	1	EWSR1	22	29695597	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	8945903	29695597	21608969	204	2584										
NF2	4771	broad.mit.edu	37	chr22	30057255	30057255	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ggggcttcacatttatgaccCtgagaacagactgaccccca	9	13	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:30057255C>T	uc003age.3	+	8	1180	c.737C>T	c.(736-738)CCT>CTT	p.P246L	NF2_uc003afy.3_Missense_Mutation_p.P246L|NF2_uc003afz.3_Missense_Mutation_p.P163L|NF2_uc003agf.3_Missense_Mutation_p.P246L|NF2_uc003agb.3_Missense_Mutation_p.P169L|NF2_uc003agc.3_Missense_Mutation_p.P208L|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Missense_Mutation_p.P246L|NF2_uc003aga.3_Missense_Mutation_p.P204L|NF2_uc003agh.3_Missense_Mutation_p.P205L|NF2_uc003agi.3_Missense_Mutation_p.P163L|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Missense_Mutation_p.P208L	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	246	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.P246fs*5(2)|p.?(1)|p.N226_E270del(1)|p.D245fs*31(1)|p.L127_D382del(1)|p.L140_P252del(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						ATTTATGACCCTGAGAACAGA	0.502			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				0	0	0	0.010729	0	11	114										T	30057255	C	T	30057255	3	4	9	1	0	0	0	0	1	0	0	0	10357	681	24	2	767	2	NF2	22	30057255	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	361658	30057255	21247311	205	2585										
APOL1	8542	broad.mit.edu	37	chr22	36661781	36661781	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcagtcagtaccgcatgcctCagcctcacgcccccgggtca	9	18	5	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:36661781C>T	uc003apf.2	+	6	1067	c.899C>T	c.(898-900)TCA>TTA	p.S300L	APOL1_uc011amn.1_Missense_Mutation_p.S177L|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.S316L|APOL1_uc011amo.1_Missense_Mutation_p.S177L|APOL1_uc011amp.1_Missense_Mutation_p.S300L|APOL1_uc011amq.1_Missense_Mutation_p.S282L|APOL1_uc010gwx.2_Missense_Mutation_p.S177L	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	300					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						CCGCATGCCTCAGCCTCACGC	0.557													0	0	0	0.00308	0	7	60										T	36661781	C	T	36661781	3	4	9	1	0	0	0	0	1	0	0	0	805	838	29	1	969	1	APOL1	22	36661781	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	6604526	36661781	14642785	206	2586										
FAM83F	113828	broad.mit.edu	37	chr22	40415261	40415261	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aagcgccgggtcccagtgtaCatcatcctggacgaggcagg	14	12	1	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:40415261C>T	uc003ayk.1	+	2	673	c.579C>T	c.(577-579)TAC>TAT	p.Y193Y		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	193										breast(1)	1						TCCCAGTGTACATCATCCTGG	0.542													0	0	0	0.024245	0	12	50										T	40415261	C	T	40415261	2	4	9	1	0	0	0	0	0	0	0	1	5638	489	17	2		2	FAM83F	22	40415261	Silent	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3753480	40415261	10889305	207	2587										
TCF20	6942	broad.mit.edu	37	chr22	42609633	42609633	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cattctgagcaccttgtgccGgtgaggagccagctttctca	11	12	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:42609633G>A	uc003bcj.1	-	1	1813	c.1679C>T	c.(1678-1680)CCG>CTG	p.P560L	TCF20_uc003bck.1_Missense_Mutation_p.P560L|TCF20_uc003bnt.2_Missense_Mutation_p.P560L	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						ACCTTGTGCCGGTGAGGAGCC	0.577													0	0	0	0.0333	0	18	82										A	42609633	G	A	42609633	3	1	9	1	0	0	0	0	1	0	0	0	15687	1116	39	2	4241	2	TCF20	22	42609633	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	2194372	42609633	8694933	208	2588										
NFAM1	150372	broad.mit.edu	37	chr22	42828309	42828310	+	Frame_Shift_Ins	INS	-	-	T													0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	cagggggctgcggggagcccINSaggagggcgtgggaggcctg							TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:42828309_42828310insT	uc003bcn.3	-	1	92_93	c.54_55insA	c.(52-57)CCTGGGfs	p.P18fs		NM_145912	NP_666017	Q8NET5	NFAM1_HUMAN	NFAT activation molecule 1 precursor	18_19					B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity				0						GCGGGGAGCCCAGGAGGGCGTG	0.663																		2	4	---	---								T	42828310	-	T	42828309	7	5	9	1	0	1	1	0	0	0	0	0	10358	594	21	0	781	0	NFAM1	22	42828309	Frame_Shift_Ins	INS	-	TCGA-BT-A20O-01A-21D-A14W-08	218676	42828309	8476257	209	2589										
CELSR1	9620	broad.mit.edu	37	chr22	46759909	46759909	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tcactcagagtcggagccatCggcctgggcgctcccagtgc	13	15	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:46759909C>T	uc003bhw.1	-	34	9019	c.9019G>A	c.(9019-9021)GAT>AAT	p.D3007N		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	3007	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCGGAGCCATCGGCCTGGGCG	0.672													0	0	0	0.004482	0	7	14										T	46759909	C	T	46759909	3	4	9	1	0	0	0	0	1	0	0	0	3221	884	31	1	33	1	CELSR1	22	46759909	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3931600	46759909	4544657	210	2590										
PLXNB2	23654	broad.mit.edu	37	chr22	50718479	50718479	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	gacatccagttggacagcatCctctccaccacagtctcaga	7	15	2	1			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chr22:50718479C>A	uc003bkv.3	-	26	4303	c.4197G>T	c.(4195-4197)AGG>AGT	p.R1399S	PLXNB2_uc003bkt.1_Missense_Mutation_p.R191S|PLXNB2_uc003bku.1_Missense_Mutation_p.R384S	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1399	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGGACAGCATCCTCTCCACCA	0.612													1	0	1.23904e-05	0.014758	1.35442e-05	5	38										A	50718479	C	A	50718479	3	1	9	1	0	0	0	0	1	0	0	0	12124	854	30	3	1367	3	PLXNB2	22	50718479	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	3958570	50718479	586087	211	2591										
IL1RAPL2	26280	broad.mit.edu	37	chrX	104478538	104478538	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	atgaaggtgtcaatgtccttGactgttgcagagaatgaatc	11	6	1	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:104478538G>C	uc004elz.1	+	4	1149	c.393G>C	c.(391-393)TTG>TTC	p.L131F		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	131	Ig-like C2-type 1.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						CAATGTCCTTGACTGTTGCAG	0.393													0	0	0	0.006214	0	9	71										C	104478538	G	C	104478538	3	2	9	1	0	0	0	0	1	0	0	0	7662	1281	45	1	403	1	IL1RAPL2	23	104478538	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08		104478538	50792022	212	2592										
RIPPLY1	92129	broad.mit.edu	37	chrX	106144121	106144121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	acagatagtcgaaggagcggGatttaggccagaagagcctg	15	7	0	3			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:106144121G>A	uc004emr.1	-	4	358	c.314C>T	c.(313-315)TCC>TTC	p.S105F	MORC4_uc004emp.3_Intron|CLDN2_uc004emq.1_Intron|RIPPLY1_uc004ems.1_Missense_Mutation_p.S58F	NM_138382	NP_612391	Q0D2K3	RIPP1_HUMAN	ripply1 homolog	105	Ripply homology domain.				negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus					0						GAAGGAGCGGGATTTAGGCCA	0.512													0	0	0	0.014758	0	5	6										A	106144121	G	A	106144121	3	1	9	1	0	0	0	0	1	0	0	0	13384	1174	41	1	145	1	RIPPLY1	23	106144121	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	1665583	106144121	49126439	213	2593										
CLDN2	9075	broad.mit.edu	37	chrX	106171926	106171926	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ccactggtgcctgacagcatGaaatttgagattggagaggc	13	8	0	4			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:106171926G>A	uc004emq.1	+	2	987	c.468G>A	c.(466-468)ATG>ATA	p.M156I	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Missense_Mutation_p.M156I	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	156	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CTGACAGCATGAAATTTGAGA	0.478													0	0	0	0.016723	0	14	63										A	106171926	G	A	106171926	3	1	9	1	0	0	0	0	1	0	0	0	3481	1290	45	1	470	1	CLDN2	23	106171926	Missense_Mutation	SNP	G	TCGA-BT-A20O-01A-21D-A14W-08	27805	106171926	49098634	214	2594										
CUL4B	8450	broad.mit.edu	37	chrX	119694330	119694330	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	aggtggaatcaaagtcttctCtctcgttactactgttactg	8	9	4	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:119694330C>T	uc004esw.2	-	3	655	c.218G>A	c.(217-219)AGA>AAA	p.R73K	CUL4B_uc004esv.2_Missense_Mutation_p.R55K	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	73	Ser-rich.				cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						AAAGTCTTCTCTCTCGTTAct	0.438													0	0	0	0.014758	0	5	15										T	119694330	C	T	119694330	3	4	9	1	0	0	0	0	1	0	0	0	4058	913	32	1	2603	1	CUL4B	23	119694330	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	13522404	119694330	35576230	215	2595										
ODZ1	10178	broad.mit.edu	37	chrX	123805551	123805551	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	accttttttctctgatttatCagaaacttttcctccaattg	3	10	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:123805551C>T	uc004euj.2	-	6	1214	c.1150G>A	c.(1150-1152)GAT>AAT	p.D384N	ODZ1_uc011muj.1_Missense_Mutation_p.D383N|ODZ1_uc010nqy.2_Missense_Mutation_p.D384N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	384	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCTGATTTATCAGAAACTTTT	0.398													0	0	0	0.004482	0	9	55										T	123805551	C	T	123805551	3	4	9	1	0	0	0	0	1	0	0	0	10834	826	29	1	7156	1	ODZ1	23	123805551	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	4111221	123805551	31465009	216	2596										
ARHGAP36	158763	broad.mit.edu	37	chrX	130219951	130219951	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	tggatctgctctcctgaaaaAaggaaagtttggcaagagag	12	6	2	2			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:130219951A>T	uc004evz.2	+	9	1514	c.1169A>T	c.(1168-1170)AAA>ATA	p.K390I	ARHGAP36_uc004ewa.2_Missense_Mutation_p.K378I|ARHGAP36_uc004ewb.2_Missense_Mutation_p.K359I|ARHGAP36_uc004ewc.2_Missense_Mutation_p.K254I	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	390	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CTCCTGAAAAAAGGAAAGTTT	0.468													0	0	0	0.02938	0	7	120										T	130219951	A	T	130219951	3	4	9	1	0	0	0	0	1	0	0	0	883	14	1	5	1199	5	ARHGAP36	23	130219951	Missense_Mutation	SNP	A	TCGA-BT-A20O-01A-21D-A14W-08	6414400	130219951	25050609	217	2597										
HCFC1	3054	broad.mit.edu	37	chrX	153225574	153225574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319444444444444	69	2.39309034188679e-17	2.93054652880355	3.61974620652612	2.64446364371116	0.00288770119193766	0.0125133718317299	45	ctccagggagttggtgttggCgcgtaccagttgtactcggg	16	9	0	0			TCGA-BT-A20O-01A-21D-A14W-08	TCGA-BT-A20O-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7df63263-de4e-4ed8-804f-9e8fee3be2d5	12e550de-383e-4ccc-8a4f-106c35bbcc5a	g.chrX:153225574C>T	uc004fjp.2	-	8	1651	c.1123G>A	c.(1123-1125)GCC>ACC	p.A375T		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	375					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGGTGTTGGCGCGTACCAGT	0.617													0	0	0	0.004672	0	3	11										T	153225574	C	T	153225574	3	4	9	1	0	0	0	0	1	0	0	0	6991	768	27	2	5060	2	HCFC1	23	153225574	Missense_Mutation	SNP	C	TCGA-BT-A20O-01A-21D-A14W-08	23005623	153225574	2044986	218	2598										
PTCHD2	57540	broad.mit.edu	37	chr1	11561646	11561646	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	caaaagcccacagccaatcgGagcgggcgacttcggcgtga	13	13	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:11561646G>C	uc001ash.3	+	2	735	c.597G>C	c.(595-597)CGG>CGC	p.R199R	PTCHD2_uc001asi.1_Silent_p.R199R	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	199	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CAGCCAATCGGAGCGGGCGAC	0.687													0	0	0	0.038147	0	7	6										C	11561646	G	C	11561646	2	2	10	1	0	0	0	0	0	0	0	1	12733	1161	41	1		1	PTCHD2	1	11561646	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08		11561646	237688975	1	2599										
EPHA10	284656	broad.mit.edu	37	chr1	38197144	38197144	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgggcctcccaggatggcccCggggaagcggcccggatctg	17	14	1	0	rs77925917	by1000genomes	TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:38197144C>T	uc009vvi.2	-	7	1688	c.1602G>A	c.(1600-1602)CCG>CCA	p.P534P	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	534	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGGATGGCCCCGGGGAAGCGG	0.597													0	0	0	0.059317	0	30	63										T	38197144	C	T	38197144	2	4	10	1	0	0	0	0	0	0	0	1	5166	639	23	2		2	EPHA10	1	38197144	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	26635498	38197144	211053477	2	2600										
MACF1	23499	broad.mit.edu	37	chr1	39818703	39818703	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aagcagcaaaggaactggcaGagaacaagaagaagatcgat	12	6	0	4			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:39818703G>C	uc010oiu.1	+	8	6675	c.6544G>C	c.(6544-6546)GAG>CAG	p.E2182Q	MACF1_uc010ois.1_Missense_Mutation_p.E1680Q|MACF1_uc001cda.1_Missense_Mutation_p.E1588Q|MACF1_uc001cdc.1_Missense_Mutation_p.E767Q|MACF1_uc001cdb.1_Missense_Mutation_p.E767Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3747					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGAACTGGCAGAGAACAAGAA	0.473													0	0	0	0.020292	0	12	23										C	39818703	G	C	39818703	3	2	10	1	0	0	0	0	1	0	0	0	9144	943	33	1	11343	1	MACF1	1	39818703	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	1621559	39818703	209431918	3	2601										
MACF1	23499	broad.mit.edu	37	chr1	39818900	39818900	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gacaagcaatgtgagatgatGaaggtaagggtgttagctta	14	3	0	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:39818900G>A	uc010oiu.1	+	8	6872	c.6741G>A	c.(6739-6741)ATG>ATA	p.M2247I	MACF1_uc010ois.1_Missense_Mutation_p.M1745I|MACF1_uc001cda.1_Missense_Mutation_p.M1653I|MACF1_uc001cdc.1_Missense_Mutation_p.M832I|MACF1_uc001cdb.1_Missense_Mutation_p.M832I	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3812					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTGAGATGATGAAGGTAAGGG	0.299													0	0	0	0.047766	0	9	11										A	39818900	G	A	39818900	3	1	10	1	0	0	0	0	1	0	0	0	9144	1290	45	1	11540	1	MACF1	1	39818900	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	197	39818900	209431721	4	2602										
RNF220	55182	broad.mit.edu	37	chr1	45101242	45101242	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	attgggaaaatgaaacggagGaagcaagatgaagggcaggt	16	3	0	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:45101242G>A	uc001clv.1	+	7	1335	c.975G>A	c.(973-975)AGG>AGA	p.R325R	RNF220_uc001clw.1_Silent_p.R325R|RNF220_uc010okx.1_Silent_p.R86R|RNF220_uc010oky.1_Silent_p.R86R|RNF220_uc010okz.1_Silent_p.R41R|RNF220_uc001clx.1_Silent_p.R41R|RNF220_uc001cly.1_Silent_p.R4R|RNF220_uc001clz.1_Silent_p.R4R|RNF220_uc001cma.1_Silent_p.R4R|TMEM53_uc001cmb.1_3'UTR	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	325					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGAAACGGAGGAAGCAAGATG	0.567													0	0	0	0.043863	0	17	26										A	45101242	G	A	45101242	2	1	10	1	0	0	0	0	0	0	0	1	13483	1165	41	1		1	RNF220	1	45101242	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	5282342	45101242	204149379	5	2603										
YIPF1	54432	broad.mit.edu	37	chr1	54332522	54332522	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgttcataactttgctgtttCtccacatgaggaaaccccag	7	11	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:54332522C>G	uc001cvu.2	-	8	894	c.557G>C	c.(556-558)AGA>ACA	p.R186T	YIPF1_uc001cvv.2_RNA|YIPF1_uc001cvw.2_RNA|YIPF1_uc001cvx.2_RNA|YIPF1_uc001cvy.2_RNA	NM_018982	NP_061855	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1	186	Cytoplasmic (Potential).					integral to membrane|transport vesicle				large_intestine(1)|ovary(1)	2						TTTGCTGTTTCTCCACATGAG	0.458													0	0	0	0.076483	0	23	28										G	54332522	C	G	54332522	3	3	10	1	0	0	0	0	1	0	0	0	17474	913	32	1	375	1	YIPF1	1	54332522	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	9231280	54332522	194918099	6	2604										
RAVER2	55225	broad.mit.edu	37	chr1	65247172	65247172	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	agacggtatgaccatcaaggGcagcaaagtccaggtttcct	11	10	1	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:65247172G>A	uc001dbs.1	+	4	974	c.896G>A	c.(895-897)GGC>GAC	p.G299D	RAVER2_uc001dbt.1_Missense_Mutation_p.G178D|RAVER2_uc010opb.1_Missense_Mutation_p.G178D	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	299	RRM 3.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						ACCATCAAGGGCAGCAAAGTC	0.517													0	0	0	0.054565	0	35	49										A	65247172	G	A	65247172	3	1	10	1	0	0	0	0	1	0	0	0	13095	1203	42	2	910	2	RAVER2	1	65247172	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	10914650	65247172	184003449	7	2605										
VAV3	10451	broad.mit.edu	37	chr1	108145726	108145726	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgtgcctcacaaggtaagtaCtatttaccctattaataagt	6	8	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:108145726C>A	uc001dvk.1	-	23	2129	c.2075G>T	c.(2074-2076)AGT>ATT	p.S692I	VAV3_uc010ouu.1_Missense_Mutation_p.S96I|VAV3_uc001dvj.1_Missense_Mutation_p.S132I|VAV3_uc010ouv.1_Missense_Mutation_p.S96I|VAV3_uc010ouw.1_Missense_Mutation_p.S692I	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	692	SH2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		AAGGTAAGTACTATTTACCCT	0.353													1	0	0.00024832	0.009096	0.000261196	4	96										A	108145726	C	A	108145726	3	1	10	1	0	0	0	0	1	0	0	0	17130	565	20	4	488	4	VAV3	1	108145726	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	42898554	108145726	141104895	8	2606										
CSF1	1435	broad.mit.edu	37	chr1	110466096	110466096	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cacagcctcgcccctctgtcGgggccttcaaccccgggatg	11	18	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:110466096G>A	uc001dyu.2	+	6	1266	c.853G>A	c.(853-855)GGG>AGG	p.G285R	CSF1_uc001dyt.2_Missense_Mutation_p.G285R|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Missense_Mutation_p.G285R	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	285	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCCCTCTGTCGGGGCCTTCAA	0.612											OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.050027	0	32	28										A	110466096	G	A	110466096	3	1	10	1	0	0	0	0	1	0	0	0	3931	1116	39	2	875	2	CSF1	1	110466096	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	2320370	110466096	138784525	9	2607										
IFI16	3428	broad.mit.edu	37	chr1	159021525	159021525	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tccatagaagacagtgcccaGagtgacctcaaagaagtgat	10	9	1	6			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:159021525G>A	uc001ftg.2	+	9	1844	c.1554G>A	c.(1552-1554)CAG>CAA	p.Q518Q	IFI16_uc010pis.1_Silent_p.Q518Q|IFI16_uc001fth.2_Silent_p.Q61Q|IFI16_uc010pit.1_Silent_p.Q117Q	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					ACAGTGCCCAGAGTGACCTCA	0.418													0	0	0	0.104719	0	44	56										A	159021525	G	A	159021525	2	1	10	1	0	0	0	0	0	0	0	1	7511	933	33	1		1	IFI16	1	159021525	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	48555429	159021525	90229096	10	2608										
PRDX6	9588	broad.mit.edu	37	chr1	173454533	173454533	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	acaattgtgaagagcccacaGaaaagttaccttttcccatc	6	11	0	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:173454533G>T	uc001giy.1	+	3	337	c.286G>T	c.(286-288)GAA>TAA	p.E96*		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	96	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						AGAGCCCACAGAAAAGTTACC	0.438													1	0	3.1745e-13	0.037714	3.60623e-13	30	35										T	173454533	G	T	173454533	4	4	10	1	0	0	0	0	0	1	0	0	12469	943	33	3	296	3	PRDX6	1	173454533	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	14433008	173454533	75796088	11	2609										
KIF21B	23046	broad.mit.edu	37	chr1	200967639	200967639	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tggctgttctccagctcgtcGatcagcttctgcttgatttc	9	12	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:200967639G>A	uc001gvs.1	-	14	2267	c.1950C>T	c.(1948-1950)ATC>ATT	p.I650I	KIF21B_uc001gvr.1_Silent_p.I650I|KIF21B_uc009wzl.1_Silent_p.I650I|KIF21B_uc010ppn.1_Silent_p.I650I	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	650	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CCAGCTCGTCGATCAGCTTCT	0.562													0	0	0	0.045705	0	32	62										A	200967639	G	A	200967639	2	1	10	1	0	0	0	0	0	0	0	1	8289	1048	37	1		1	KIF21B	1	200967639	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	27513106	200967639	48282982	12	2610										
EPRS	2058	broad.mit.edu	37	chr1	220162081	220162081	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	actttgagataatgggggctGaccaggtatgtactccttcc	11	9	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:220162081G>A	uc001hly.1	-	19	2896	c.2626C>T	c.(2626-2628)CAG>TAG	p.Q876*	EPRS_uc010puf.1_Nonsense_Mutation_p.Q627*|EPRS_uc001hlz.1_Nonsense_Mutation_p.Q883*	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	876	WHEP-TRS 2.|3 X 57 AA approximate repeats.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AATGGGGGCTGACCAGGTATG	0.403													0	0	0	0.048971	0	66	62										A	220162081	G	A	220162081	4	1	10	1	0	0	0	0	0	1	0	0	5191	1299	45	1	1968	1	EPRS	1	220162081	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	19194442	220162081	29088540	13	2611										
RAB3GAP2	25782	broad.mit.edu	37	chr1	220331158	220331158	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttttacctccattaagatctGaagaagatccaaacaggagc	7	9	1	4			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:220331158G>C	uc010puk.1	-	30	3486	c.3322C>G	c.(3322-3324)CAG>GAG	p.Q1108E	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.Q688E|RAB3GAP2_uc001hmh.2_Missense_Mutation_p.Q52E	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	1108					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		ATTAAGATCTGAAGAAGATCC	0.363													0	0	0	0.043863	0	16	17										C	220331158	G	C	220331158	3	2	10	1	0	0	0	0	1	0	0	0	12936	1299	45	1	883	1	RAB3GAP2	1	220331158	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	169077	220331158	28919463	14	2612										
FAM36A	116228	broad.mit.edu	37	chr1	245006464	245006464	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctgaaagaaaacacaacggcAgcagcagcaattgaacaatc	8	10	0	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr1:245006464A>G	uc001iar.2	+	4	721	c.343A>G	c.(343-345)AGC>GGC	p.S115G	FAM36A_uc001ias.2_RNA|FAM36A_uc001iat.2_RNA|NCRNA00201_uc001iav.2_RNA	NM_198076	NP_932342	Q5RI15	FA36A_HUMAN	hypothetical protein LOC116228	115						integral to membrane					0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			ACACAACGGCAGCAGCAGCAA	0.363													0	0	0	0.049695	0	19	31										G	245006464	A	G	245006464	3	3	10	1	0	0	0	0	1	0	0	0	5554	188	7	5	357	5	FAM36A	1	245006464	Missense_Mutation	SNP	A	TCGA-BT-A20P-01A-11D-A14W-08	24675306	245006464	4244157	15	2613										
DYSF	8291	broad.mit.edu	37	chr2	71748031	71748031	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctggggcctggggacgaagcGcctgtgagtacatttccctg	15	11	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr2:71748031G>A	uc002sie.2	+	11	1426	c.1050G>A	c.(1048-1050)GCG>GCA	p.A350A	DYSF_uc010feg.2_Silent_p.A381A|DYSF_uc010feh.2_Silent_p.A350A|DYSF_uc002sig.3_Silent_p.A350A|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.A350A|DYSF_uc010fef.2_Silent_p.A381A|DYSF_uc010fei.2_Silent_p.A381A|DYSF_uc010fek.2_Silent_p.A382A|DYSF_uc010fej.2_Silent_p.A351A|DYSF_uc010fel.2_Silent_p.A351A|DYSF_uc010feo.2_Silent_p.A382A|DYSF_uc010fem.2_Silent_p.A351A|DYSF_uc010fen.2_Silent_p.A382A|DYSF_uc002sif.2_Silent_p.A351A	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	350	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GGGACGAAGCGCCTGTGAGTA	0.532													0	0	0	0.0333	0	17	28										A	71748031	G	A	71748031	2	1	10	1	0	0	0	0	0	0	0	1	4859	1074	38	2		2	DYSF	2	71748031	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08		71748031	171451342	16	2614										
SLC5A7	60482	broad.mit.edu	37	chr2	108626805	108626805	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ggctctggtacctcagttctGaccttgtttacatcgttatc	8	11	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr2:108626805G>C	uc002tdv.2	+	9	1507	c.1231G>C	c.(1231-1233)GAC>CAC	p.D411H	SLC5A7_uc010ywm.1_Missense_Mutation_p.D164H|SLC5A7_uc010fjj.2_Missense_Mutation_p.D411H|SLC5A7_uc010ywn.1_Missense_Mutation_p.D298H	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	411	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CCTCAGTTCTGACCTTGTTTA	0.488													0	0	0	0.041601	0	32	40										C	108626805	G	C	108626805	3	2	10	1	0	0	0	0	1	0	0	0	14670	1290	45	1	1261	1	SLC5A7	2	108626805	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	36878774	108626805	134572568	17	2615										
LRP1B	53353	broad.mit.edu	37	chr2	141457909	141457909	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gtaaaagattcggttggtacCttttcttctttgattatagt	8	5	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr2:141457909C>G	uc002tvj.1	-	41	7681	c.6709G>C	c.(6709-6711)GGT>CGT	p.G2237R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2237	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGGTTGGTACCTTTTCTTCTT	0.348										TSP Lung(27;0.18)			0	0	0	0.09836	0	42	55										G	141457909	C	G	141457909	3	3	10	1	0	0	0	0	1	0	0	0	8955	681	24	4	7294	4	LRP1B	2	141457909	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	32831104	141457909	101741464	18	2616										
TTN	7273	broad.mit.edu	37	chr2	179650718	179650718	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aggctcagctacctttgcggCggaaatgcgttccttatatc	10	11	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr2:179650718C>T	uc010zfg.1	-	14	2451	c.2227G>A	c.(2227-2229)GCC>ACC	p.A743T	TTN_uc010zfh.1_Missense_Mutation_p.A697T|TTN_uc010zfi.1_Missense_Mutation_p.A697T|TTN_uc010zfj.1_Missense_Mutation_p.A697T|TTN_uc002unb.2_Missense_Mutation_p.A743T|TTN_uc010frg.1_Missense_Mutation_p.A325T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	743							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTGCGGCGGAAATGCGT	0.547													0	0	0	0.083992	0	24	33										T	179650718	C	T	179650718	3	4	10	1	0	0	0	0	1	0	0	0	16732	768	27	2	109157	2	TTN	2	179650718	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	38192809	179650718	63548655	19	2617										
ZSWIM2	151112	broad.mit.edu	37	chr2	187694567	187694567	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	attcttagtaatcagttggaGaggcagtgatcttacaatgt	10	5	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr2:187694567G>T	uc002upu.1	-	8	1022	c.982C>A	c.(982-984)CTC>ATC	p.L328I		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	328					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATCAGTTGGAGAGGCAGTGAT	0.393													1	0	8.01111e-26	0.039052	9.55948e-26	42	64										T	187694567	G	T	187694567	3	4	10	1	0	0	0	0	1	0	0	0	18238	942	33	3	927	3	ZSWIM2	2	187694567	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	8043849	187694567	55504806	20	2618										
ECEL1	9427	broad.mit.edu	37	chr2	233345140	233345140	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aggggcatgcttgtcagtcaGcacctgcaggtagatggact	14	9	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr2:233345140G>A	uc002vsv.2	-	17	2402	c.2197C>T	c.(2197-2199)CTG>TTG	p.L733L	ECEL1_uc010fya.1_Silent_p.L731L|ECEL1_uc010fyb.1_Silent_p.L440L	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	733	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TTGTCAGTCAGCACCTGCAGG	0.637													0	0	0	0.0333	0	16	28										A	233345140	G	A	233345140	2	1	10	1	0	0	0	0	0	0	0	1	4891	962	34	2		2	ECEL1	2	233345140	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	45650573	233345140	9854233	21	2619										
EDEM1	9695	broad.mit.edu	37	chr3	5248946	5248946	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gactctctgcaggcctttttCcctggactgcaggtattttg	10	11	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:5248946C>A	uc003bqi.2	+	7	1458	c.1326C>A	c.(1324-1326)TTC>TTA	p.F442L	EDEM1_uc011asz.1_Missense_Mutation_p.F220L|EDEM1_uc003bqh.2_Missense_Mutation_p.F442L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	442	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AGGCCTTTTTCCCTGGACTGC	0.458													1	0	5.44703e-19	0.11126	6.39238e-19	42	49										A	5248946	C	A	5248946	3	1	10	1	0	0	0	0	1	0	0	0	4911	854	30	3	1352	3	EDEM1	3	5248946	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		5248946	192773484	22	2620										
EDEM1	9695	broad.mit.edu	37	chr3	5251877	5251877	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	taggcaaccaagaatcccttCtacctccatgtaggaatgga	8	11	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:5251877C>G	uc003bqi.2	+	9	1659	c.1527C>G	c.(1525-1527)TTC>TTG	p.F509L	EDEM1_uc003bqh.2_Missense_Mutation_p.F509L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	509	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AGAATCCCTTCTACCTCCATG	0.448													0	0	0	0.064281	0	31	50										G	5251877	C	G	5251877	3	3	10	1	0	0	0	0	1	0	0	0	4911	912	32	1	1561	1	EDEM1	3	5251877	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	2931	5251877	192770553	23	2621										
GRM7	2917	broad.mit.edu	37	chr3	7721860	7721860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgaactcaatgtccagaaacGgaagcgaagcttcaaggcgg	12	9	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:7721860G>A	uc003bqm.2	+	9	2850	c.2576G>A	c.(2575-2577)CGG>CAG	p.R859Q	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.R859Q|GRM7_uc003bql.2_Missense_Mutation_p.R859Q|GRM7_uc003bqn.1_Missense_Mutation_p.R442Q	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	859	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GTCCAGAAACGGAAGCGAAGC	0.517													0	0	0	0.069288	0	22	26										A	7721860	G	A	7721860	3	1	10	1	0	0	0	0	1	0	0	0	6802	1116	39	2	2610	2	GRM7	3	7721860	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	2469983	7721860	190300570	24	2622										
MST1R	4486	broad.mit.edu	37	chr3	49929005	49929005	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ggcctccacctgctgcatctCtgtgatgcctgcagagcagc	11	15	1	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:49929005C>A	uc003cxy.3	-	16	3625	c.3361G>T	c.(3361-3363)GAG>TAG	p.E1121*	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1121	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGCTGCATCTCTGTGATGCCT	0.582													1	0	2.42023e-17	0.059317	2.81699e-17	32	32										A	49929005	C	A	49929005	4	1	10	1	0	0	0	0	0	1	0	0	9891	922	32	3	861	3	MST1R	3	49929005	Nonsense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	42207145	49929005	148093425	25	2623										
SENP7	57337	broad.mit.edu	37	chr3	101085458	101085458	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gcacttttggtggcattactCaaagtcaactcctgactgtt	8	10	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:101085458C>G	uc003dut.2	-	9	1245	c.1134G>C	c.(1132-1134)TTG>TTC	p.L378F	SENP7_uc003duu.2_Missense_Mutation_p.L313F|SENP7_uc003duv.2_Missense_Mutation_p.L345F|SENP7_uc003duw.2_Missense_Mutation_p.L312F|SENP7_uc003dux.2_Missense_Mutation_p.L214F	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	378					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						TGGCATTACTCAAAGTCAACT	0.403													0	0	0	0.074837	0	34	41										G	101085458	C	G	101085458	3	3	10	1	0	0	0	0	1	0	0	0	14051	825	29	1	2082	1	SENP7	3	101085458	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	51156453	101085458	96936972	26	2624										
ZBTB11	27107	broad.mit.edu	37	chr3	101370486	101370486	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttttagagatcgggcatcagCccaagctactccacatgtta	8	11	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:101370486C>T	uc003dve.3	-	11	2916	c.2686G>A	c.(2686-2688)GCT>ACT	p.A896T		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	896	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CGGGCATCAGCCCAAGCTACT	0.418													0	0	0	0.064281	0	34	37										T	101370486	C	T	101370486	3	4	10	1	0	0	0	0	1	0	0	0	17521	739	26	2	479	2	ZBTB11	3	101370486	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	285028	101370486	96651944	27	2625										
EPHB3	2049	broad.mit.edu	37	chr3	184295484	184295484	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	acagtgaccagccagatgaaCtccgtgcagctggacgggct	13	12	0	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr3:184295484C>T	uc003foz.2	+	7	1955	c.1518C>T	c.(1516-1518)AAC>AAT	p.N506N		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	506	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GCCAGATGAACTCCGTGCAGC	0.657													0	0	0	0.080422	0	37	42										T	184295484	C	T	184295484	2	4	10	1	0	0	0	0	0	0	0	1	5176	564	20	2		2	EPHB3	3	184295484	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	82924998	184295484	13726946	28	2626										
TACC3	10460	broad.mit.edu	37	chr4	1746708	1746708	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aggagctgaccaggatctgcGacgacctcatctccaagatg	11	12	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr4:1746708G>A	uc003gdo.2	+	16	2593	c.2485G>A	c.(2485-2487)GAC>AAC	p.D829N	TACC3_uc003gdp.2_Missense_Mutation_p.D469N|TACC3_uc010ica.2_Missense_Mutation_p.D250N	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	829	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGGATCTGCGACGACCTCAT	0.597													0	0	0	0.048971	0	80	5										A	1746708	G	A	1746708	3	1	10	1	0	0	0	0	1	0	0	0	15500	1058	37	1	2543	1	TACC3	4	1746708	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08		1746708	189407568	29	2627										
STBD1	8987	broad.mit.edu	37	chr4	77230916	77230916	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	acaagcactgatgtgcaattCattgcagtaactggagacca	9	9	1	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr4:77230916C>T	uc003hka.2	+	2	1086	c.840C>T	c.(838-840)TTC>TTT	p.F280F	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_Silent_p.F131F	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	280	CBM20.|Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			ATGTGCAATTCATTGCAGTAA	0.473													0	0	0	0.069288	0	21	25										T	77230916	C	T	77230916	2	4	10	1	0	0	0	0	0	0	0	1	15273	825	29	1		1	STBD1	4	77230916	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	75484208	77230916	113923360	30	2628										
HMGB2	3148	broad.mit.edu	37	chr4	174254073	174254073	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	acccaatttctttgcagtatCcccaatggataggccagggt	9	11	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr4:174254073C>G	uc011ckc.1	-	3	490	c.370G>C	c.(370-372)GAT>CAT	p.D124H	HMGB2_uc003ita.3_Missense_Mutation_p.D124H|HMGB2_uc003itb.2_Missense_Mutation_p.D124H|HMGB2_uc003itc.2_3'UTR	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	124	HMG box 2.				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TTTGCAGTATCCCCAATGGAT	0.408													0	0	0	0.048971	0	76	104										G	174254073	C	G	174254073	3	3	10	1	0	0	0	0	1	0	0	0	7226	855	30	1	267	1	HMGB2	4	174254073	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	97023157	174254073	16900203	31	2629										
PPIC	5480	broad.mit.edu	37	chr5	122359598	122359598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cagcgatctcaaccacaaaaGgcgttttcacgtctatcttg	7	12	4	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr5:122359598G>A	uc003kth.2	-	5	716	c.611C>T	c.(610-612)CCT>CTT	p.P204L		NM_000943	NP_000934	P45877	PPIC_HUMAN	peptidylprolyl isomerase C	204					protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			ovary(1)	1		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	AACCACAAAAGGCGTTTTCAC	0.413													0	0	0	0.048971	0	134	76										A	122359598	G	A	122359598	3	1	10	1	0	0	0	0	1	0	0	0	12320	1000	35	2	31	2	PPIC	5	122359598	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08		122359598	58555662	32	2630										
SEPT8	23176	broad.mit.edu	37	chr5	132100049	132100049	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctcatggtgactggcttcctCagtctcgaaggtcgtgttga	12	10	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr5:132100049C>T	uc003kxr.2	-	3	452	c.214G>A	c.(214-216)GAG>AAG	p.E72K	SEPT8_uc003kxs.1_Missense_Mutation_p.E72K|SEPT8_uc003kxu.2_Missense_Mutation_p.E72K|SEPT8_uc011cxi.1_Missense_Mutation_p.E72K|SEPT8_uc003kxv.2_Missense_Mutation_p.E72K|SEPT8_uc003kxt.2_Missense_Mutation_p.E12K	NM_001098811	NP_001092281	Q92599	SEPT8_HUMAN	septin 8 isoform a	72					cell cycle	septin complex	GTP binding|protein binding			ovary(2)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGGCTTCCTCAGTCTCGAAG	0.582													0	0	0	0.076483	0	21	11										T	132100049	C	T	132100049	3	4	10	1	0	0	0	0	1	0	0	0	14070	835	29	1	1324	1	SEPT8	5	132100049	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	9740451	132100049	48815211	33	2631										
FBXL21	26223	broad.mit.edu	37	chr5	135273129	135273129	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tctaggttgacagtagcgctGagtcagcagaagctgcctgt	13	9	2	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr5:135273129G>C	uc010jec.1	+	3	403	c.382G>C	c.(382-384)GAG>CAG	p.E128Q	FBXL21_uc003lbc.2_RNA	NM_012159	NP_036291	Q9UKT6	FXL21_HUMAN	F-box and leucine-rich repeat protein 21	128					rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAGTAGCGCTGAGTCAGCAGA	0.378													0	0	0	0.080935	0	12	38										C	135273129	G	C	135273129	3	2	10	1	0	0	0	0	1	0	0	0	5718	1291	45	1	388	1	FBXL21	5	135273129	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3173080	135273129	45642131	34	2632										
PCDHAC1	56135	broad.mit.edu	37	chr5	140306671	140306671	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttccagccaccgcgagctctActtcggggtggatctaccca	10	15	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr5:140306671A>G	uc003lih.2	+	1	370	c.194A>G	c.(193-195)TAC>TGC	p.Y65C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.Y65C	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	65	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGAGCTCTACTTCGGGGTG	0.637													0	0	0	0.045705	0	29	12										G	140306671	A	G	140306671	3	3	10	1	0	0	0	0	1	0	0	0	11532	391	14	5	196	5	PCDHAC1	5	140306671	Missense_Mutation	SNP	A	TCGA-BT-A20P-01A-11D-A14W-08	5033542	140306671	40608589	35	2633										
HIST1H2BA	255626	broad.mit.edu	37	chr6	25727255	25727255	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gacccgtaaggagagttattCtatttacatctacaaagtgc	8	8	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr6:25727255C>G	uc003nfd.2	+	1	119	c.119C>G	c.(118-120)TCT>TGT	p.S40C	HIST1H2AA_uc003nfc.2_5'Flank	NM_170610	NP_733759	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	40					nucleosome assembly	nucleosome|nucleus	DNA binding			kidney(1)	1						GAGAGTTATTCTATTTACATC	0.428													0	0	0	0.080422	0	38	20										G	25727255	C	G	25727255	3	3	10	1	0	0	0	0	1	0	0	0	7140	913	32	1	121	1	HIST1H2BA	6	25727255	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		25727255	145387812	36	2634										
OR2H2	7932	broad.mit.edu	37	chr6	29556637	29556637	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tcaggagattgctggggaagGaaatggggctcacacaaagc	15	7	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr6:29556637G>C	uc003nmr.1	+	1	955	c.916G>C	c.(916-918)GAA>CAA	p.E306Q	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	306	Cytoplasmic (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCTGGGGAAGGAAATGGGGCT	0.478													0	0	0	0.0333	0	18	27										C	29556637	G	C	29556637	3	2	10	1	0	0	0	0	1	0	0	0	11002	1175	41	1	918	1	OR2H2	6	29556637	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3829382	29556637	141558430	37	2635										
HLA-A	3105	broad.mit.edu	37	chr6	29913231	29913231	+	Nonstop_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aatatttttttctatagtgtGagacagctgccttgtgtggg	11	5	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr6:29913231G>T	uc003nol.2	+	8	1097	c.1097G>T	c.(1096-1098)TGA>TTA	p.*366L	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc003non.2_Nonstop_Mutation_p.*372L|HLA-A_uc003noo.2_Nonsense_Mutation_p.E367*|HLA-A_uc010jrr.2_Nonstop_Mutation_p.*300L|HLA-A_uc003nom.2_Nonsense_Mutation_p.E244*|HLA-A_uc011dmc.1_Nonstop_Mutation_p.*245L|HLA-A_uc011dmd.1_3'UTR	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	366					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTATAGTGTGAGACAGCTGC	0.448									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			1	0	2.35188e-11	0.038395	2.60912e-11	14	37										T	29913231	G	T	29913231	4	4	10	1	0	0	0	0	0	0	0	0	7195	1285	45	3	1127	3	HLA-A	6	29913231	Nonstop_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	356594	29913231	141201836	38	2636										
BAT2	7916	broad.mit.edu	37	chr6	31597445	31597445	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ccctgggggctgtgccagctCcacaggctccacccccgccc	11	21	0	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr6:31597445C>A	uc003nvb.3	+	14	2326	c.2077C>A	c.(2077-2079)CCA>ACA	p.P693T	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P693T	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	693	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TGTGCCAGCTCCACAGGCTCC	0.572													1	0	7.92952e-12	0.0918	8.93645e-12	25	41										A	31597445	C	A	31597445	3	1	10	1	0	0	0	0	1	0	0	0	1319	855	30	3	2127	3	BAT2	6	31597445	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	1684214	31597445	139517622	39	2637										
COL12A1	1303	broad.mit.edu	37	chr6	75884895	75884895	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tcccctcacagtgacctcttGagtttcaccccctgccactg	6	18	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr6:75884895G>T	uc003phs.2	-	13	2735	c.2569C>A	c.(2569-2571)CAA>AAA	p.Q857K	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	857	Fibronectin type-III 5.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GTGACCTCTTGAGTTTCACCC	0.498													1	0	5.41189e-41	0.048971	6.6249e-41	71	109										T	75884895	G	T	75884895	3	4	10	1	0	0	0	0	1	0	0	0	3669	1299	45	3	6838	3	COL12A1	6	75884895	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	44287450	75884895	95230172	40	2638										
KPNA5	3841	broad.mit.edu	37	chr6	117053364	117053364	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tttaccagaaggcatttgatCtgattgaacattactttggt	8	6	1	4			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr6:117053364C>G	uc003pxh.2	+	14	1629	c.1498C>G	c.(1498-1500)CTG>GTG	p.L500V		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	497	ARM 10; atypical.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		GGCATTTGATCTGATTGAACA	0.343													0	0	0	0.086207	0	33	40										G	117053364	C	G	117053364	3	3	10	1	0	0	0	0	1	0	0	0	8433	912	32	1	1552	1	KPNA5	6	117053364	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	41168469	117053364	54061703	41	2639										
FZD1	8321	broad.mit.edu	37	chr7	90895308	90895308	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gtggccgtggcctacatcgcCggcttcctcctggaagaccg	13	15	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr7:90895308C>T	uc003ula.2	+	1	1526	c.1113C>T	c.(1111-1113)GCC>GCT	p.A371A		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	371	Helical; Name=2; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCTACATCGCCGGCTTCCTCC	0.632													0	0	0	0.041601	0	29	64										T	90895308	C	T	90895308	2	4	10	1	0	0	0	0	0	0	0	1	6128	639	23	2		2	FZD1	7	90895308	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		90895308	68243355	42	2640										
DOCK4	9732	broad.mit.edu	37	chr7	111379265	111379265	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gacaggcaagagttttctcgGgaatgtttgtgtttgtcaga	13	5	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr7:111379265G>T	uc003vfx.2	-	48	5399	c.5130C>A	c.(5128-5130)TCC>TCA	p.S1710S	DOCK4_uc011kml.1_Silent_p.S591S|DOCK4_uc011kmm.1_Silent_p.S617S|DOCK4_uc003vfw.2_Silent_p.S1160S|DOCK4_uc003vfy.2_Silent_p.S1755S|DOCK4_uc003vfv.2_Silent_p.S23S	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1710	Ser-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				AGTTTTCTCGGGAATGTTTGT	0.502													1	0	0.00448238	0.047766	0.00464597	6	74										T	111379265	G	T	111379265	2	4	10	1	0	0	0	0	0	0	0	1	4689	1219	43	4		4	DOCK4	7	111379265	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	20483957	111379265	47759398	43	2641										
LUC7L2	51631	broad.mit.edu	37	chr7	139094364	139094365	+	Frame_Shift_Ins	INS	-	-	AG													0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gaacggctgaaacgaagagaINSagagagagagagagaagaaa							TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr7:139094364_139094365insAG	uc003vux.2	+	7	1117_1118	c.743_744insAG	c.(742-744)GAAfs	p.E248fs	LUC7L2_uc011kqs.1_Frame_Shift_Ins_p.E245fs|LUC7L2_uc011kqt.1_Frame_Shift_Ins_p.E314fs|LUC7L2_uc003vuy.2_Frame_Shift_Ins_p.E247fs|LUC7L2_uc003vuz.1_Frame_Shift_Ins_p.E195fs|LUC7L2_uc003vva.2_Frame_Shift_Ins_p.E195fs	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	248	Arg/Ser-rich.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)					AAACGAAGAGAAGAGAGAGAGA	0.396																		6	11	---	---								AG	139094365	-	AG	139094364	7	5	10	1	0	1	1	0	0	0	0	0	9083	246	9	0	769	0	LUC7L2	7	139094364	Frame_Shift_Ins	INS	-	TCGA-BT-A20P-01A-11D-A14W-08	27715099	139094364	20044299	44	2642										
NAT1	9	broad.mit.edu	37	chr8	18080042	18080042	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aatggattctggtatctagaCcaaatcagaagggaacagta	10	6	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr8:18080042C>G	uc010ltd.2	+	5	853	c.486C>G	c.(484-486)GAC>GAG	p.D162E	NAT1_uc003wyt.2_Missense_Mutation_p.D224E|NAT1_uc003wyu.2_Missense_Mutation_p.D162E|NAT1_uc003wyv.2_Missense_Mutation_p.D162E|NAT1_uc010ltc.2_Missense_Mutation_p.D162E|NAT1_uc003wys.2_Missense_Mutation_p.D224E|NAT1_uc003wyr.2_Missense_Mutation_p.D162E|NAT1_uc003wyq.2_Missense_Mutation_p.D162E|NAT1_uc011kyl.1_Missense_Mutation_p.D162E	NM_001160179	NP_001153651	P18440	ARY1_HUMAN	N-acetyltransferase 1 isoform a	162					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity				0				Colorectal(111;0.0519)|COAD - Colon adenocarcinoma(73;0.208)		GGTATCTAGACCAAATCAGAA	0.428													0	0	0	0.092188	0	39	54										G	18080042	C	G	18080042	3	3	10	1	0	0	0	0	1	0	0	0	10173	506	18	4	682	4	NAT1	8	18080042	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		18080042	128283980	45	2643										
DENND3	22898	broad.mit.edu	37	chr8	142151335	142151335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tctacaatggcaaaacgcacCgggagtgtcctggctgcttc	11	12	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr8:142151335C>T	uc003yvy.2	+	4	573	c.295C>T	c.(295-297)CGG>TGG	p.R99W	DENND3_uc003yvw.1_Missense_Mutation_p.R112W|DENND3_uc003yvx.2_Silent_p.T177T|DENND3_uc010mep.2_Missense_Mutation_p.R112W	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	99										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CAAAACGCACCGGGAGTGTCC	0.537													0	0	0	0.014758	0	5	57										T	142151335	C	T	142151335	3	4	10	1	0	0	0	0	1	0	0	0	4432	643	23	2	305	2	DENND3	8	142151335	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	124071293	142151335	4212687	46	2644										
ARHGAP39	80728	broad.mit.edu	37	chr8	145773665	145773665	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gaagggtgacggcctcctctCtgggaagaagatggtgccgt	16	9	1	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr8:145773665C>T	uc003zdt.1	-	6	1360	c.805G>A	c.(805-807)GAG>AAG	p.E269K	ARHGAP39_uc011llk.1_Missense_Mutation_p.E269K|ARHGAP39_uc003zds.1_Missense_Mutation_p.E269K	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	269	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GGCCTCCTCTCTGGGAAGAAG	0.716													0	0	0	0.021553	0	6	4										T	145773665	C	T	145773665	3	4	10	1	0	0	0	0	1	0	0	0	884	922	32	1	2571	1	ARHGAP39	8	145773665	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	3622330	145773665	590357	47	2645										
ALDH1B1	219	broad.mit.edu	37	chr9	38396624	38396624	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ggtggtaagagccccagcatCgtgctggccgatgctgacat	14	11	0	2	rs141592792		TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr9:38396624C>T	uc004aay.2	+	2	991	c.879C>T	c.(877-879)ATC>ATT	p.I293I		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	293					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	GCCCCAGCATCGTGCTGGCCG	0.617													0	0	0	0.108266	0	26	33										T	38396624	C	T	38396624	2	4	10	1	0	0	0	0	0	0	0	1	493	874	31	1		1	ALDH1B1	9	38396624	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		38396624	102816807	48	2646										
FKBP15	23307	broad.mit.edu	37	chr9	115936807	115936807	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gacttgcgaatttcatctatCtcctcctcggcctgagaacg	8	13	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr9:115936807C>G	uc004bgs.2	-	22	2398	c.2280G>C	c.(2278-2280)GAG>GAC	p.E760D	FKBP15_uc004bgr.2_Missense_Mutation_p.E197D|FKBP15_uc011lxc.1_Missense_Mutation_p.E341D|FKBP15_uc011lxd.1_Missense_Mutation_p.E692D	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	760	Potential.				endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						TTTCATCTATCTCCTCCTCGG	0.468													0	0	0	0.048971	0	59	15										G	115936807	C	G	115936807	3	3	10	1	0	0	0	0	1	0	0	0	5905	912	32	1	1407	1	FKBP15	9	115936807	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	77540183	115936807	25276624	49	2647										
TLR4	7099	broad.mit.edu	37	chr9	120475702	120475702	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	catctggatttccagcattcCaatttgaaacaaatgagtga	7	8	1	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr9:120475702C>T	uc004bjz.2	+	3	1587	c.1296C>T	c.(1294-1296)TCC>TCT	p.S432S	TLR4_uc004bka.2_Silent_p.S392S|TLR4_uc004bkb.2_Silent_p.S232S	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	432	LRR 13.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TCCAGCATTCCAATTTGAAAC	0.378													0	0	0	0.086207	0	40	12										T	120475702	C	T	120475702	2	4	10	1	0	0	0	0	0	0	0	1	15950	581	21	2		2	TLR4	9	120475702	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	4538895	120475702	20737729	50	2648										
FUBP3	8939	broad.mit.edu	37	chr9	133499065	133499065	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gatcggtgtcagcatgcagcGcatatcatcagcgagctgat	12	10	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr9:133499065G>T	uc004bzr.1	+	11	1050	c.942G>T	c.(940-942)GCG>GCT	p.A314A	FUBP3_uc010mzd.1_Silent_p.A254A|FUBP3_uc004bzs.1_Silent_p.A227A	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	314	KH 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGCATGCAGCGCATATCATCA	0.557													1	0	6.33239e-15	0.055883	7.2516e-15	19	4										T	133499065	G	T	133499065	2	4	10	1	0	0	0	0	0	0	0	1	6093	1074	38	4		4	FUBP3	9	133499065	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	13023363	133499065	7714366	51	2649										
TSC1	7248	broad.mit.edu	37	chr9	135781358	135781358	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gcttgtccagggaggagtgtAaaggctcagggttcacgctg	16	8	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr9:135781358A>T	uc004cca.2	-	15	1841	c.1607T>A	c.(1606-1608)TTA>TAA	p.L536*	TSC1_uc004ccb.3_Nonsense_Mutation_p.L535*|TSC1_uc011mcq.1_Nonsense_Mutation_p.L485*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	536					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GGAGGAGTGTAAAGGCTCAGG	0.587			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.083992	0	24	5										T	135781358	A	T	135781358	4	4	10	1	0	0	0	0	0	1	0	0	16602	372	13	5	1923	5	TSC1	9	135781358	Nonsense_Mutation	SNP	A	TCGA-BT-A20P-01A-11D-A14W-08	2282293	135781358	5432073	52	2650										
ZNF25	219749	broad.mit.edu	37	chr10	38241395	38241395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	atgttttcccacatttattaCattcaaagggtttctcccct	4	11	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr10:38241395C>T	uc001ize.1	-	6	1136	c.1031G>A	c.(1030-1032)TGT>TAT	p.C344Y	ZNF25_uc001izf.1_Missense_Mutation_p.C308Y	NM_145011	NP_659448	P17030	ZNF25_HUMAN	zinc finger protein 25	344	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|central_nervous_system(1)	4		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				ACATTTATTACATTCAAAGGG	0.413													0	0	0	0.028581	0	17	29										T	38241395	C	T	38241395	3	4	10	1	0	0	0	0	1	0	0	0	17791	478	17	2	343	2	ZNF25	10	38241395	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		38241395	97293352	53	2651										
LRRC20	55222	broad.mit.edu	37	chr10	72061222	72061222	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ggttgaagcggaggttgatgCtgcgcaaggctggcatggcg	19	7	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr10:72061222C>T	uc001jqx.1	-	5	665	c.443G>A	c.(442-444)AGC>AAC	p.S148N	LRRC20_uc001jqy.1_Missense_Mutation_p.S92N|LRRC20_uc001jqz.1_Missense_Mutation_p.S98N	NM_207119	NP_997002	Q8TCA0	LRC20_HUMAN	leucine rich repeat containing 20 isoform 1	148	LRR 5.										0						GAGGTTGATGCTGCGCAAGGC	0.592													0	0	0	0.048971	0	45	74										T	72061222	C	T	72061222	3	4	10	1	0	0	0	0	1	0	0	0	8977	797	28	2	115	2	LRRC20	10	72061222	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	33819827	72061222	63473525	54	2652										
CAMK2G	818	broad.mit.edu	37	chr10	75602237	75602237	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttcagttttctccgggcattGaacttgcgcaaacactccac	7	13	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr10:75602237G>C	uc001jvv.1	-	11	982	c.858C>G	c.(856-858)TTC>TTG	p.F286L	CAMK2G_uc001jvm.1_Missense_Mutation_p.F294L|CAMK2G_uc001jvo.1_Missense_Mutation_p.F294L|CAMK2G_uc001jvq.1_Missense_Mutation_p.F294L|CAMK2G_uc001jvr.1_Missense_Mutation_p.F294L|CAMK2G_uc001jvp.1_Missense_Mutation_p.F294L|CAMK2G_uc001jvs.1_Missense_Mutation_p.F294L|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Missense_Mutation_p.F272L|CAMK2G_uc010qkv.1_Missense_Mutation_p.F13L|CAMK2G_uc009xrp.1_5'Flank	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	294	Calmodulin-binding.|Calmodulin-binding (By similarity).				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					TCCGGGCATTGAACTTGCGCA	0.542													0	0	0	0.108266	0	23	31										C	75602237	G	C	75602237	3	2	10	1	0	0	0	0	1	0	0	0	2602	1281	45	1	932	1	CAMK2G	10	75602237	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3541015	75602237	59932510	55	2653										
KCNMA1	3778	broad.mit.edu	37	chr10	78799315	78799315	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gtagggaaggacagacccacGaaggcactggagagatattc	14	8	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr10:78799315G>A	uc001jxn.2	-	15	2007	c.1830C>T	c.(1828-1830)TTC>TTT	p.F610F	KCNMA1_uc001jxj.2_Silent_p.F610F|KCNMA1_uc001jxk.1_Silent_p.F225F|KCNMA1_uc009xrt.1_Silent_p.F430F|KCNMA1_uc001jxl.1_Silent_p.F264F|KCNMA1_uc001jxo.2_Silent_p.F610F|KCNMA1_uc001jxm.2_Silent_p.F610F|KCNMA1_uc001jxq.2_Silent_p.F610F	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	610	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	ACAGACCCACGAAGGCACTGG	0.448													0	0	0	0.028581	0	17	26										A	78799315	G	A	78799315	2	1	10	1	0	0	0	0	0	0	0	1	8073	1049	37	1		1	KCNMA1	10	78799315	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3197078	78799315	56735432	56	2654										
BTAF1	9044	broad.mit.edu	37	chr10	93751913	93751913	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gatggaatgcaccatactgtCaccaagcacagaggtataat	9	9	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr10:93751913C>A	uc001khr.2	+	21	2990	c.2892C>A	c.(2890-2892)GTC>GTA	p.V964V	BTAF1_uc001kht.1_Silent_p.V402V	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	964					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ACCATACTGTCACCAAGCACA	0.398													1	0	6.84511e-11	0.059317	7.53493e-11	32	36										A	93751913	C	A	93751913	2	1	10	1	0	0	0	0	0	0	0	1	1536	813	29	3		3	BTAF1	10	93751913	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	14952598	93751913	41782834	57	2655										
EIF4G2	1982	broad.mit.edu	37	chr11	10821251	10821251	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aggagtgggaataagaaactCagtccctttccttccaaaat	8	9	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr11:10821251C>G	uc001mjc.2	-	19	2589	c.2172G>C	c.(2170-2172)CTG>CTC	p.L724L	EIF4G2_uc001mjb.2_Silent_p.L518L|EIF4G2_uc009ygf.2_Silent_p.L518L|EIF4G2_uc001mjd.2_Silent_p.L686L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	724	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ATAAGAAACTCAGTCCCTTTC	0.378													0	0	0	0.11126	0	40	45										G	10821251	C	G	10821251	2	3	10	1	0	0	0	0	0	0	0	1	5037	813	29	1		1	EIF4G2	11	10821251	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		10821251	124185265	58	2656										
CYP2R1	120227	broad.mit.edu	37	chr11	14900872	14900872	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aaatccctaatggaactataTtacagaatcttaaaacttca	3	8	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr11:14900872T>C	uc001mlr.2	-	4	1118	c.1118A>G	c.(1117-1119)AAT>AGT	p.N373S	CYP2R1_uc001mlo.2_Missense_Mutation_p.N140S|CYP2R1_uc001mlp.2_Missense_Mutation_p.N256S|CYP2R1_uc001mlq.2_Intron	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	373					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	TGGAACTATATTACAGAATCT	0.368													0	0	0	0.055883	0	20	27										C	14900872	T	C	14900872	3	2	10	1	0	0	0	0	1	0	0	0	4173	1493	52	5	395	5	CYP2R1	11	14900872	Missense_Mutation	SNP	T	TCGA-BT-A20P-01A-11D-A14W-08	4079621	14900872	120105644	59	2657										
SLC1A2	6506	broad.mit.edu	37	chr11	35308446	35308446	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gaatctagtcacacgcttatCaatccccagattttcttcca	4	13	4	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr11:35308446C>A	uc001mwd.2	-	8	1736	c.1144G>T	c.(1144-1146)GAT>TAT	p.D382Y	SLC1A2_uc001mwe.2_Missense_Mutation_p.D373Y|SLC1A2_uc010rev.1_Missense_Mutation_p.D382Y	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	382					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	ACACGCTTATCAATCCCCAGA	0.458													1	0	3.30712e-30	0.048971	3.97975e-30	65	88										A	35308446	C	A	35308446	3	1	10	1	0	0	0	0	1	0	0	0	14432	826	29	3	596	3	SLC1A2	11	35308446	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	20407574	35308446	99698070	60	2658										
COPS7A	50813	broad.mit.edu	37	chr12	6837406	6837406	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tagctgaagcccggaatcttCctccactaacagaggctcag	9	13	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:6837406C>G	uc001qqj.2	+	4	495	c.256C>G	c.(256-258)CCT>GCT	p.P86A	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Missense_Mutation_p.P86A|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Missense_Mutation_p.P86A|COPS7A_uc001qqi.2_Missense_Mutation_p.P86A|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Missense_Mutation_p.P86A|COPS7A_uc001qqo.2_Missense_Mutation_p.P86A	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	86	PCI.				cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						CCGGAATCTTCCTCCACTAAC	0.512													0	0	0	0.043863	0	17	49										G	6837406	C	G	6837406	3	3	10	1	0	0	0	0	1	0	0	0	3738	855	30	1	266	1	COPS7A	12	6837406	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		6837406	127014489	61	2659										
RIMKLB	57494	broad.mit.edu	37	chr12	8926379	8926379	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aatcaaactactggtggactGactccactggtaattaacca	7	10	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:8926379G>C	uc001quu.2	+	6	1411	c.1160G>C	c.(1159-1161)TGA>TCA	p.*387S	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Nonstop_Mutation_p.*387S|RIMKLB_uc010sgl.1_Nonstop_Mutation_p.*387S|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	387					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CTGGTGGACTGACTCCACTGG	0.458													0	0	0	0.048971	0	53	58										C	8926379	G	C	8926379	4	2	10	1	0	0	0	0	0	0	0	0	13366	1285	45	1	1178	1	RIMKLB	12	8926379	Nonstop_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	2088973	8926379	124925516	62	2660										
MGP	4256	broad.mit.edu	37	chr12	15035937	15035937	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tttagctctccatctctgctGaggggatatgaaggtatttg	11	7	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:15035937G>A	uc001rcn.1	-	3	242	c.139C>T	c.(139-141)CAG>TAG	p.Q47*		NM_000900	NP_000891	P08493	MGP_HUMAN	matrix Gla protein precursor	47					cartilage condensation|cell differentiation|ossification|regulation of bone mineralization	proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent|structural constituent of bone			ovary(1)	1						CATCTCTGCTGAGGGGATATG	0.393													0	0	0	0.050027	0	24	31										A	15035937	G	A	15035937	4	1	10	1	0	0	0	0	0	1	0	0	9558	1299	45	1	180	1	MGP	12	15035937	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	6109558	15035937	118815958	63	2661										
ITGA7	3679	broad.mit.edu	37	chr12	56088080	56088080	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctcaatgaagacacgggctcGtgcagagactggatgcagct	13	10	1	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:56088080G>A	uc001shh.2	-	18	2624	c.2404C>T	c.(2404-2406)CGA>TGA	p.R802*	ITGA7_uc001shg.2_Nonsense_Mutation_p.R798*|ITGA7_uc010sps.1_Nonsense_Mutation_p.R705*|ITGA7_uc009znw.2_Nonsense_Mutation_p.R45*|ITGA7_uc009znx.2_Nonsense_Mutation_p.R679*	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	842	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						ACACGGGCTCGTGCAGAGACT	0.602													0	0	0	0.048971	0	118	77										A	56088080	G	A	56088080	4	1	10	1	0	0	0	0	0	1	0	0	7881	1153	40	2	1053	2	ITGA7	12	56088080	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	41052143	56088080	77763815	64	2662										
TMTC2	160335	broad.mit.edu	37	chr12	83289890	83289890	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aacctacacactgtggccttCtatactggactccttctcct	5	15	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:83289890C>G	uc001szt.2	+	3	1380	c.948C>G	c.(946-948)TTC>TTG	p.F316L	TMTC2_uc001szr.1_Missense_Mutation_p.F316L|TMTC2_uc001szs.1_Missense_Mutation_p.F316L|TMTC2_uc010suk.1_Missense_Mutation_p.F71L	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	316	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CTGTGGCCTTCTATACTGGAC	0.458													0	0	0	0.080422	0	36	107										G	83289890	C	G	83289890	3	3	10	1	0	0	0	0	1	0	0	0	16258	912	32	1	958	1	TMTC2	12	83289890	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	27201810	83289890	50562005	65	2663										
RPH3A	22895	broad.mit.edu	37	chr12	113304588	113304588	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgcaccaagtgcggagtggaGaccaacaaccgcctgcattc	11	13	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:113304588G>C	uc010syl.1	+	7	749	c.387G>C	c.(385-387)GAG>GAC	p.E129D	RPH3A_uc001ttz.2_Missense_Mutation_p.E129D|RPH3A_uc001tty.2_Missense_Mutation_p.E125D|RPH3A_uc009zwe.1_Missense_Mutation_p.E125D|RPH3A_uc010sym.1_Missense_Mutation_p.E80D|RPH3A_uc001tua.2_5'Flank	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	129	RabBD.|FYVE-type.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCGGAGTGGAGACCAACAACC	0.562													0	0	0	0.004672	0	3	16										C	113304588	G	C	113304588	3	2	10	1	0	0	0	0	1	0	0	0	13551	933	33	1	405	1	RPH3A	12	113304588	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	30014698	113304588	20547307	66	2664										
ZCCHC8	55596	broad.mit.edu	37	chr12	122975027	122975027	+	Frame_Shift_Del	DEL	G	G	-													0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	acctggggcaaaagattaaaGgaagtcttttccacatcatt							TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:122975027delG	uc001ucn.2	-	4	536	c.405delC	c.(403-405)TCCfs	p.S135fs	ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	135						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		AAAGATTAAAGGAAGTCTTTT	0.338																		20	27	---	---								-	122975027	G	-	122975027	7	5	10	1	0	1	0	1	0	0	0	0	17591	987	35	0	1762	0	ZCCHC8	12	122975027	Frame_Shift_Del	DEL	G	TCGA-BT-A20P-01A-11D-A14W-08	9670439	122975027	10876868	67	2665										
RSRC2	65117	broad.mit.edu	37	chr12	122999747	122999747	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aaacttctgctaaatcttctCggcttttcaattctcttctt	3	11	6	0	rs142949567		TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr12:122999747C>T	uc001ucr.2	-	6	776	c.630G>A	c.(628-630)CCG>CCA	p.P210P	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Silent_p.P151P|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Silent_p.P162P|RSRC2_uc001ucu.2_Silent_p.P210P	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	210										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TAAATCTTCTCGGCTTTTCAA	0.383													0	0	0	0.009096	0	4	105										T	122999747	C	T	122999747	2	4	10	1	0	0	0	0	0	0	0	1	13715	871	31	1		1	RSRC2	12	122999747	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	24720	122999747	10852148	68	2666										
C13orf28	122258	broad.mit.edu	37	chr13	113053427	113053427	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctggtggttctgagaattacCatgaattattagagaattta	9	4	1	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr13:113053427C>A	uc001vsd.1	+	4	320	c.289C>A	c.(289-291)CAT>AAT	p.H97N		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	97						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					TGAGAATTACCATGAATTATT	0.373													1	0	3.41278e-10	0.0333	3.69935e-10	17	32										A	113053427	C	A	113053427	3	1	10	1	0	0	0	0	1	0	0	0	1724	594	21	4	303	4	C13orf28	13	113053427	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		113053427	2116451	69	2667										
CHD8	57680	broad.mit.edu	37	chr14	21868445	21868445	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctttttttcctttgcgtccaCgaggcacagggatagataga	10	9	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr14:21868445C>T	uc001was.1	-	24	3849	c.3755G>A	c.(3754-3756)CGT>CAT	p.R1252H	CHD8_uc001war.1_Missense_Mutation_p.R1148H|SNORD8_uc001wau.1_5'Flank|CHD8_uc001wav.1_Missense_Mutation_p.R702H	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1531					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTTGCGTCCACGAGGCACAGG	0.403													0	0	0	0.020292	0	13	24										T	21868445	C	T	21868445	3	4	10	1	0	0	0	0	1	0	0	0	3331	536	19	2	3213	2	CHD8	14	21868445	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		21868445	85481095	70	2668										
VPS13C	54832	broad.mit.edu	37	chr15	62201309	62201309	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttcggcagtgtttacatccaCcaagatacccccattctatt	5	13	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr15:62201309C>G	uc002agz.2	-	65	8934	c.8860G>C	c.(8860-8862)GTG>CTG	p.V2954L	VPS13C_uc002aha.2_Missense_Mutation_p.V2911L|VPS13C_uc002ahb.1_Missense_Mutation_p.V2954L|VPS13C_uc002ahc.1_Missense_Mutation_p.V2911L|VPS13C_uc002ahd.1_Missense_Mutation_p.V331L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2954					protein localization					ovary(2)	2						TTTACATCCACCAAGATACCC	0.353													0	0	0	0.062417	0	19	41										G	62201309	C	G	62201309	3	3	10	1	0	0	0	0	1	0	0	0	17188	507	18	4	2513	4	VPS13C	15	62201309	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		62201309	40330083	71	2669										
NEO1	4756	broad.mit.edu	37	chr15	73528817	73528817	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cggagacaaccttacctactCtgtgttctacaccaaggaag	8	12	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr15:73528817C>G	uc002avm.3	+	8	1563	c.1421C>G	c.(1420-1422)TCT>TGT	p.S474C	NEO1_uc010ukx.1_Missense_Mutation_p.S474C|NEO1_uc010uky.1_Missense_Mutation_p.S474C|NEO1_uc010ukz.1_5'UTR|NEO1_uc002avn.3_Missense_Mutation_p.S139C	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	474	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CTTACCTACTCTGTGTTCTAC	0.567													0	0	0	0.080422	0	33	55										G	73528817	C	G	73528817	3	3	10	1	0	0	0	0	1	0	0	0	10336	913	32	1	1451	1	NEO1	15	73528817	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	11327508	73528817	29002575	72	2670										
SNX33	257364	broad.mit.edu	37	chr15	75942367	75942367	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttcatcgaaaagcggaagcgGagactcatcctctggatgga	12	9	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr15:75942367G>C	uc002bau.2	+	1	1020	c.924G>C	c.(922-924)CGG>CGC	p.R308R	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_5'UTR	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	308	PX.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						AGCGGAAGCGGAGACTCATCC	0.582													0	0	0	0.080422	0	37	72										C	75942367	G	C	75942367	2	2	10	1	0	0	0	0	0	0	0	1	14903	1161	41	1		1	SNX33	15	75942367	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	2413550	75942367	26589025	73	2671										
CLEC16A	23274	broad.mit.edu	37	chr16	11114144	11114144	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	accacggacgaggagaaaagCgccgccgccacctgctctga	12	15	1	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr16:11114144C>T	uc002dao.2	+	12	1628	c.1398C>T	c.(1396-1398)AGC>AGT	p.S466S	CLEC16A_uc002dan.3_Silent_p.S448S	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	466								p.0?(1)		ovary(1)|central_nervous_system(1)	2						AGGAGAAAAGCGCCGCCGCCA	0.617													0	0	0	0.009096	0	4	16										T	11114144	C	T	11114144	2	4	10	1	0	0	0	0	0	0	0	1	3500	767	27	2		2	CLEC16A	16	11114144	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		11114144	79240609	74	2672										
C16orf87	388272	broad.mit.edu	37	chr16	46836943	46836943	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	acacgaaagccttttcatcaGacaggttagcatagatgtca	8	9	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr16:46836943G>C	uc002eek.1	-	4	399	c.386C>G	c.(385-387)TCT>TGT	p.S129C		NM_001001436	NP_001001436	Q6PH81	CP087_HUMAN	hypothetical protein LOC388272	129	Potential.										0						CTTTTCATCAGACAGGTTAGC	0.313													0	0	0	0.024245	0	16	23										C	46836943	G	C	46836943	3	2	10	1	0	0	0	0	1	0	0	0	1840	942	33	1	82	1	C16orf87	16	46836943	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	35722799	46836943	43517810	75	2673										
ABCC11	85320	broad.mit.edu	37	chr16	48250187	48250187	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tagtttacatcaccggtgaaGaagctgatggcctgcaagac	11	9	1	4			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr16:48250187G>C	uc002eff.1	-	6	1139	c.789C>G	c.(787-789)TTC>TTG	p.F263L	ABCC11_uc002efg.1_Missense_Mutation_p.F263L|ABCC11_uc002efh.1_Missense_Mutation_p.F263L|ABCC11_uc010vgk.1_5'Flank|ABCC11_uc010vgl.1_Missense_Mutation_p.F263L	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	263	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CACCGGTGAAGAAGCTGATGG	0.552									Cerumen_Type				0	0	0	0.048971	0	49	50										C	48250187	G	C	48250187	3	2	10	1	0	0	0	0	1	0	0	0	51	933	33	1	3455	1	ABCC11	16	48250187	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	1413244	48250187	42104566	76	2674										
RPGRIP1L	23322	broad.mit.edu	37	chr16	53721797	53721797	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	atttcttatttctcctctggCttcttcaagtaaactgttgc	5	10	5	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr16:53721797C>G	uc002ehp.2	-	5	674	c.610G>C	c.(610-612)GCC>CCC	p.A204P	RPGRIP1L_uc002eho.3_Missense_Mutation_p.A204P|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.A204P|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.A204P|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.A204P|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.A204P	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	204	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TCTCCTCTGGCTTCTTCAAGT	0.303													0	0	0	0.048971	0	40	84										G	53721797	C	G	53721797	3	3	10	1	0	0	0	0	1	0	0	0	13550	797	28	4	3429	4	RPGRIP1L	16	53721797	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	5471610	53721797	36632956	77	2675										
NOB1	28987	broad.mit.edu	37	chr16	69776441	69776441	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gagtcgcagctgagggaagcGctgatcctcggtgagatggg	18	8	0	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr16:69776441G>A	uc002exs.2	-	9	1049	c.1033C>T	c.(1033-1035)CGC>TGC	p.R345C		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	345						nucleus	metal ion binding|protein binding				0						TGAGGGAAGCGCTGATCCTCG	0.552													0	0	0	0.069456	0	33	37										A	69776441	G	A	69776441	3	1	10	1	0	0	0	0	1	0	0	0	10511	1087	38	2	209	2	NOB1	16	69776441	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	16054644	69776441	20578312	78	2676										
FANCA	2175	broad.mit.edu	37	chr16	89869700	89869700	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tcaggctccacagttcttctCagatctgagtttttctgaaa	7	10	5	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr16:89869700C>G	uc002fou.1	-	8	801	c.759G>C	c.(757-759)CTG>CTC	p.L253L	FANCA_uc010vpn.1_Silent_p.L253L|FANCA_uc002fov.1_Silent_p.L236L|FANCA_uc002fow.1_Silent_p.L253L|FANCA_uc002fox.1_Silent_p.L253L|FANCA_uc010ciu.1_Silent_p.L221L|FANCA_uc002foy.2_Silent_p.L253L	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	253					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		CAGTTCTTCTCAGATCTGAGT	0.393			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.048971	0	52	60										G	89869700	C	G	89869700	2	3	10	1	0	0	0	0	0	0	0	1	5662	813	29	1		1	FANCA	16	89869700	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	20093259	89869700	485053	79	2677										
KIAA0664	23277	broad.mit.edu	37	chr17	2598209	2598209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gcagatgttcttccagagctCctggggggtcatgacagccc	13	12	2	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:2598209C>T	uc002fuy.1	-	16	2763	c.2677G>A	c.(2677-2679)GAG>AAG	p.E893K	KIAA0664_uc002fux.1_Missense_Mutation_p.E826K|KIAA0664_uc010ckc.1_5'UTR	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	893							binding			breast(2)	2						TTCCAGAGCTCCTGGGGGGTC	0.632													0	0	0	0.02938	0	7	0										T	2598209	C	T	2598209	3	4	10	1	0	0	0	0	1	0	0	0	8189	864	30	1	1296	1	KIAA0664	17	2598209	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		2598209	78597001	80	2678										
MYH2	4620	broad.mit.edu	37	chr17	10430322	10430322	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	taaaggcttgtttgcctcttGataactgagacaccagagct	9	9	1	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:10430322G>C	uc010coi.2	-	29	4051	c.3923C>G	c.(3922-3924)TCA>TGA	p.S1308*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.S1308*|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1308	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTTGCCTCTTGATAACTGAGA	0.373													0	0	0	0.099896	0	25	3										C	10430322	G	C	10430322	4	2	10	1	0	0	0	0	0	1	0	0	10035	1294	45	1	1950	1	MYH2	17	10430322	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	7832113	10430322	70764888	81	2679										
MYO15A	51168	broad.mit.edu	37	chr17	18082089	18082089	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	actgtcacctgcagggactgGaactgtgtcgtgtggtggcc	15	10	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:18082089G>T	uc010vxh.1	+	65	10836	c.10498G>T	c.(10498-10500)GAA>TAA	p.E3500*	uc002gsn.2_Intron|MYO15A_uc010vxi.1_Missense_Mutation_p.G781V|MYO15A_uc002gsl.2_Missense_Mutation_p.G532V|MYO15A_uc010vxm.1_3'UTR|MYO15A_uc010cpv.2_RNA	NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	3500	Tail.|FERM.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCAGGGACTGGAACTGTGTCG	0.592													1	0	1.85244e-09	0.083992	1.99278e-09	19	6										T	18082089	G	T	18082089	4	4	10	1	0	0	0	0	0	1	0	0	10063	1175	41	3	10752	3	MYO15A	17	18082089	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	7651767	18082089	63113121	82	2680										
KIAA0100	9703	broad.mit.edu	37	chr17	26943411	26943411	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tggtacctctggcgatttgcGaaatgaccttctgaccccag	10	12	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:26943411G>A	uc002hbu.2	-	36	6373	c.6274C>T	c.(6274-6276)CGC>TGC	p.R2092C	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_RNA|KIAA0100_uc002hbt.2_Missense_Mutation_p.R421C	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2092						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GGCGATTTGCGAAATGACCTT	0.527													0	0	0	0.074837	0	35	108										A	26943411	G	A	26943411	3	1	10	1	0	0	0	0	1	0	0	0	8154	1058	37	1	449	1	KIAA0100	17	26943411	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	8861322	26943411	54251799	83	2681										
NF1	4763	broad.mit.edu	37	chr17	29657369	29657369	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gtacctttaatttaaaaatcGagggccagttactagagaca	8	7	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:29657369G>A	uc002hgg.2	+	39	5998	c.5665G>A	c.(5665-5667)GAG>AAG	p.E1889K	NF1_uc002hgh.2_Missense_Mutation_p.E1868K|NF1_uc002hgi.1_Missense_Mutation_p.E901K|NF1_uc010cso.2_Missense_Mutation_p.E77K	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1889					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTTAAAAATCGAGGGCCAGTT	0.393			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.09836	0	38	75										A	29657369	G	A	29657369	3	1	10	1	0	0	0	0	1	0	0	0	10356	1059	37	1	5880	1	NF1	17	29657369	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	2713958	29657369	51537841	84	2682										
ADAM11	4185	broad.mit.edu	37	chr17	42855099	42855099	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctggcggacggctctgacctGagctatgtggaggatggcac	16	10	1	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:42855099G>C	uc002ihh.2	+	23	1938	c.1938G>C	c.(1936-1938)CTG>CTC	p.L646L	ADAM11_uc010wjd.1_Silent_p.L446L|ADAM11_uc002ihi.2_5'UTR	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	646	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GCTCTGACCTGAGCTATGTGG	0.642													0	0	0	0.059317	0	31	22										C	42855099	G	C	42855099	2	2	10	1	0	0	0	0	0	0	0	1	235	1277	45	1		1	ADAM11	17	42855099	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	13197730	42855099	38340111	85	2683										
GNGT2	2793	broad.mit.edu	37	chr17	47284179	47284179	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttgtcctcagggatgcctttGagaaaaggatcgtttcctgc	11	9	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:47284179G>C	uc002ioo.1	-	4	457	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_031498	NP_113686	O14610	GBGT2_HUMAN	guanine nucleotide binding protein-gamma	50					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GGATGCCTTTGAGAAAAGGAT	0.493													0	0	0	0.048971	0	60	44										C	47284179	G	C	47284179	2	2	10	1	0	0	0	0	0	0	0	1	6534	1277	45	1		1	GNGT2	17	47284179	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	4429080	47284179	33911031	86	2684										
TOB1	10140	broad.mit.edu	37	chr17	48940623	48940623	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgctgctgtggtggtggtggTggcggtggcggctgggctgg	24	6	0	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:48940623T>C	uc002isw.2	-	1	791	c.756A>G	c.(754-756)CCA>CCG	p.P252P	TOB1_uc010wmy.1_Silent_p.P252P|TOB1_uc010wmz.1_Silent_p.P252P	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	252	Poly-Pro.				negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			gtggtggtggtggcggtggcg	0.264													0	0	0	0.004672	0	3	34										C	48940623	T	C	48940623	2	2	10	1	0	0	0	0	0	0	0	1	16344	1683	59	5		5	TOB1	17	48940623	Silent	SNP	T	TCGA-BT-A20P-01A-11D-A14W-08	1656444	48940623	32254587	87	2685										
ABCA10	10349	broad.mit.edu	37	chr17	67148283	67148283	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttatttctagtaaataatctCtaccaaacttgtttttcaga	3	7	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:67148283C>G	uc010dfa.1	-	37	5177	c.4298G>C	c.(4297-4299)AGA>ACA	p.R1433T	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Missense_Mutation_p.R425T|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1433	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TAAATAATCTCTACCAAACTT	0.388													0	0	0	0.049695	0	19	36										G	67148283	C	G	67148283	3	3	10	1	0	0	0	0	1	0	0	0	29	913	32	1	349	1	ABCA10	17	67148283	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	18207660	67148283	14046927	88	2686										
EIF4A3	9775	broad.mit.edu	37	chr17	78120641	78120641	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tcccgcaggcccatggtgtcGaacgtgggggtcacatccac	13	14	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr17:78120641G>C	uc010wuc.1	-	2	193	c.120C>G	c.(118-120)TTC>TTG	p.F40L	EIF4A3_uc002jxs.2_Missense_Mutation_p.F40L	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	40	Q motif.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			CCATGGTGTCGAACGTGGGGG	0.473													0	0	0	0.09319	0	12	45										C	78120641	G	C	78120641	3	2	10	1	0	0	0	0	1	0	0	0	5026	1049	37	1	1163	1	EIF4A3	17	78120641	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	10972358	78120641	3074569	89	2687										
LAMA3	3909	broad.mit.edu	37	chr18	21357556	21357556	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctgtttctacaccaagttcaGaagatccagtagctggagat	9	9	2	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr18:21357556G>C	uc002kuq.2	+	11	1527	c.1441G>C	c.(1441-1443)GAA>CAA	p.E481Q	LAMA3_uc010dlv.1_Missense_Mutation_p.E481Q|LAMA3_uc002kur.2_Missense_Mutation_p.E481Q	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	481	Domain V.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCAAGTTCAGAAGATCCAGT	0.328													0	0	0	0.064281	0	32	64										C	21357556	G	C	21357556	3	2	10	1	0	0	0	0	1	0	0	0	8607	943	33	1	1483	1	LAMA3	18	21357556	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08		21357556	56719692	90	2688										
DCC	1630	broad.mit.edu	37	chr18	50923757	50923757	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tgaattctcggtcatggtaaCaaaaaacagaaggtccagta	9	7	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr18:50923757C>A	uc002lfe.1	+	18	3355	c.2768C>A	c.(2767-2769)ACA>AAA	p.T923K	DCC_uc010xdr.1_Missense_Mutation_p.T751K|DCC_uc010dpf.1_Missense_Mutation_p.T558K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	923	Extracellular (Potential).|Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTCATGGTAACAAAAAACAGA	0.423													1	0	0.00909568	0.009096	0.00935932	4	68										A	50923757	C	A	50923757	3	1	10	1	0	0	0	0	1	0	0	0	4282	478	17	4	2838	4	DCC	18	50923757	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	29566201	50923757	27153491	91	2689										
DCC	1630	broad.mit.edu	37	chr18	50985745	50985745	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ccctgcaggaagggactctcCcatccaaagttgccaagacc	9	15	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr18:50985745C>A	uc002lfe.1	+	24	4123	c.3536C>A	c.(3535-3537)CCC>CAC	p.P1179H	DCC_uc010dpf.1_Missense_Mutation_p.P814H	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1179	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGGGACTCTCCCATCCAAAGT	0.478													1	0	2.40265e-35	0.048971	2.91604e-35	55	64										A	50985745	C	A	50985745	3	1	10	1	0	0	0	0	1	0	0	0	4282	623	22	4	3630	4	DCC	18	50985745	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	61988	50985745	27091503	92	2690										
ZNF532	55205	broad.mit.edu	37	chr18	56587489	56587489	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aaagaacctcgttttttacaAcaaatgcagcctcctttccc	4	13	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr18:56587489A>C	uc002lho.2	+	4	2517	c.1970A>C	c.(1969-1971)AAC>ACC	p.N657T	ZNF532_uc002lhp.2_Missense_Mutation_p.N655T|ZNF532_uc010xeg.1_Missense_Mutation_p.N655T|ZNF532_uc002lhr.2_Missense_Mutation_p.N655T|ZNF532_uc002lhs.2_Missense_Mutation_p.N655T	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	657					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GTTTTTTACAACAAATGCAGC	0.478													0	0	0	0.004672	0	3	60										C	56587489	A	C	56587489	3	2	10	1	0	0	0	0	1	0	0	0	17969	43	2	5	1972	5	ZNF532	18	56587489	Missense_Mutation	SNP	A	TCGA-BT-A20P-01A-11D-A14W-08	5601744	56587489	21489759	93	2691										
RAVER1	125950	broad.mit.edu	37	chr19	10428414	10428414	+	Frame_Shift_Del	DEL	C	C	-													0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ccggggctgaggcccaggagCccttctccggaccccagcgg							TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:10428414delC	uc002moa.2	-	12	2156	c.2076delG	c.(2074-2076)GGGfs	p.G692fs	FDX1L_uc002mnx.1_5'Flank|FDX1L_uc002mny.1_5'Flank|RAVER1_uc002mnz.2_Frame_Shift_Del_p.G60fs	NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	519						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GGCCCAGGAGCCCTTCTCCGG	0.697																		2	4	---	---								-	10428414	C	-	10428414	7	5	10	1	0	1	0	1	0	0	0	0	13094	726	26	0	202	0	RAVER1	19	10428414	Frame_Shift_Del	DEL	C	TCGA-BT-A20P-01A-11D-A14W-08		10428414	48700569	94	2692										
NOTCH3	4854	broad.mit.edu	37	chr19	15276879	15276879	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	agcccccccacagaaggaagCcagcattagcggggtgaagc	13	13	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:15276879C>A	uc002nan.2	-	30	5462	c.5386G>T	c.(5386-5388)GCT>TCT	p.A1796S		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1796	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CAGAAGGAAGCCAGCATTAGC	0.552													1	0	3.45872e-05	0.028581	3.66521e-05	16	23										A	15276879	C	A	15276879	3	1	10	1	0	0	0	0	1	0	0	0	10550	739	26	4	1595	4	NOTCH3	19	15276879	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	4848465	15276879	43852104	95	2693										
ANKRD27	84079	broad.mit.edu	37	chr19	33117659	33117659	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctgacaggccaggtggagcgGagtggctccatggtagtctg	17	9	1	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:33117659G>T	uc002ntn.1	-	16	1651	c.1495C>A	c.(1495-1497)CCG>ACG	p.P499T		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	499	ANK 3.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					AGGTGGAGCGGAGTGGCTCCA	0.607													1	0	1.6384e-10	0.02938	1.78964e-10	5	2										T	33117659	G	T	33117659	3	4	10	1	0	0	0	0	1	0	0	0	655	1174	41	3	1713	3	ANKRD27	19	33117659	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	17840780	33117659	26011324	96	2694										
KIAA0355	9710	broad.mit.edu	37	chr19	34791438	34791438	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aagcggcgcttcctgcttggCgggtccaagcagaaggtgca	15	11	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:34791438C>T	uc002nvd.3	+	2	919	c.60C>T	c.(58-60)GGC>GGT	p.G20G	KIAA0355_uc010edk.1_Silent_p.G10G	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	20										ovary(1)	1	Esophageal squamous(110;0.162)					TCCTGCTTGGCGGGTCCAAGC	0.622													0	0	0	0.004672	0	3	43										T	34791438	C	T	34791438	2	4	10	1	0	0	0	0	0	0	0	1	8170	755	27	2		2	KIAA0355	19	34791438	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	1673779	34791438	24337545	97	2695										
PRX	57716	broad.mit.edu	37	chr19	40902836	40902836	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cacctttgggagtttcatctCtgacaccttggggagctcca	10	12	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:40902836C>T	uc002onr.2	-	7	1692	c.1423G>A	c.(1423-1425)GAG>AAG	p.E475K	PRX_uc002onq.2_Missense_Mutation_p.E336K|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	475	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|7.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGTTTCATCTCTGACACCTTG	0.582													0	0	0	0.048971	0	56	95										T	40902836	C	T	40902836	3	4	10	1	0	0	0	0	1	0	0	0	12642	922	32	1	2966	1	PRX	19	40902836	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	6111398	40902836	18226147	98	2696										
PRX	57716	broad.mit.edu	37	chr19	40903232	40903232	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ctctccccgggcctccacctCtgcacccggcaaggccaggt	10	20	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:40903232C>T	uc002onr.2	-	7	1296	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K	PRX_uc002onq.2_Missense_Mutation_p.E204K|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	343					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCTCCACCTCTGCACCCGGC	0.652													0	0	0	0.062417	0	17	31										T	40903232	C	T	40903232	3	4	10	1	0	0	0	0	1	0	0	0	12642	922	32	1	3362	1	PRX	19	40903232	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	396	40903232	18225751	99	2697										
KLK12	43849	broad.mit.edu	37	chr19	51535219	51535219	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gggcaggggcaggggttgaaCgctgctggttacgcggacgg	21	8	0	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:51535219C>T	uc002pvg.1	-	3	490	c.370G>A	c.(370-372)GTT>ATT	p.V124I	KLK12_uc010ycp.1_RNA|KLK12_uc010ycq.1_Intron|KLK12_uc010ycr.1_Intron|KLK12_uc010ycs.1_Intron|KLK12_uc002pvh.1_Missense_Mutation_p.V124I|KLK12_uc002pvi.1_Missense_Mutation_p.V124I|KLK12_uc002pvj.1_Intron	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	124	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		AGGGGTTGAACGCTGCTGGTT	0.677													0	0	0	0.043863	0	19	32										T	51535219	C	T	51535219	3	4	10	1	0	0	0	0	1	0	0	0	8400	536	19	2	450	2	KLK12	19	51535219	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	10631987	51535219	7593764	100	2698										
LILRA2	11027	broad.mit.edu	37	chr19	55085555	55085555	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tcttccagggctgagtctggGccccaggacccacgtgcagg	14	14	2	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:55085555G>A	uc002qgg.3	+	2	136	c.47G>A	c.(46-48)GGC>GAC	p.G16D	LILRA2_uc010ern.2_Missense_Mutation_p.G16D|LILRA2_uc002qgf.2_Missense_Mutation_p.G16D|LILRA2_uc010yfe.1_Missense_Mutation_p.G16D|LILRA2_uc010yff.1_Intron|LILRA2_uc010ero.2_Intron|LILRA2_uc010yfg.1_Missense_Mutation_p.G16D	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	16					defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CTGAGTCTGGGCCCCAGGACC	0.647													0	0	0	0.041601	0	31	53										A	55085555	G	A	55085555	3	1	10	1	0	0	0	0	1	0	0	0	8785	1203	42	2	53	2	LILRA2	19	55085555	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3550336	55085555	4043428	101	2699										
ZSCAN1	284312	broad.mit.edu	37	chr19	58563891	58563891	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ttctggatgcagtggcagcaGccccagcactccccgaggaa	12	14	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr19:58563891G>A	uc002qrc.1	+	5	746	c.499G>A	c.(499-501)GCC>ACC	p.A167T		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	167					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGTGGCAGCAGCCCCAGCACT	0.652													0	0	0	0.059317	0	32	25										A	58563891	G	A	58563891	3	1	10	1	0	0	0	0	1	0	0	0	18223	971	34	2	509	2	ZSCAN1	19	58563891	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3478336	58563891	565092	102	2700										
MMP9	4318	broad.mit.edu	37	chr20	44640373	44640373	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cgggacaagctcttcggcttCtgcccgacccgaggtacctc	11	16	2	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr20:44640373C>A	uc002xqz.2	+	6	1003	c.984C>A	c.(982-984)TTC>TTA	p.F328L		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	328	Fibronectin type-II 2.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TCTTCGGCTTCTGCCCGACCC	0.637											OREG0025989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.12685e-05	0.047766	1.2031e-05	8	30										A	44640373	C	A	44640373	3	1	10	1	0	0	0	0	1	0	0	0	9669	912	32	3	1006	3	MMP9	20	44640373	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		44640373	18385147	103	2701										
SYCP2	10388	broad.mit.edu	37	chr20	58439419	58439419	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tactgacatcagttctctgcGtacattaagaagctcctctt	6	11	3	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr20:58439419G>A	uc002yaz.2	-	44	4679	c.4540C>T	c.(4540-4542)CGC>TGC	p.R1514C		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1514					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AGTTCTCTGCGTACATTAAGA	0.299													0	0	0	0.02938	0	6	14										A	58439419	G	A	58439419	3	1	10	1	0	0	0	0	1	0	0	0	15429	1145	40	2	56	2	SYCP2	20	58439419	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	13799046	58439419	4586101	104	2702										
C20orf20	55257	broad.mit.edu	37	chr20	61428556	61428556	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aaggtcatctgggaccatctGagcaccatgtacgacatgca	10	11	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr20:61428556G>C	uc002ydi.2	+	2	314	c.243G>C	c.(241-243)CTG>CTC	p.L81L		NM_018270	NP_060740	Q9NV56	MRGBP_HUMAN	MRG-binding protein	81					chromatin modification|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	H4/H2A histone acetyltransferase complex					0	Breast(26;3.65e-08)					GGGACCATCTGAGCACCATGT	0.607													0	0	0	0.028581	0	17	33										C	61428556	G	C	61428556	2	2	10	1	0	0	0	0	0	0	0	1	2103	1277	45	1		1	C20orf20	20	61428556	Silent	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	2989137	61428556	1596964	105	2703										
C20orf20	55257	broad.mit.edu	37	chr20	61429948	61429948	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tttgatatcagcatgagtctGagattcttccattcccgaat	7	9	3	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr20:61429948G>C	uc002ydi.2	+	3	351	c.280G>C	c.(280-282)GAG>CAG	p.E94Q		NM_018270	NP_060740	Q9NV56	MRGBP_HUMAN	MRG-binding protein	94					chromatin modification|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	H4/H2A histone acetyltransferase complex					0	Breast(26;3.65e-08)					GCATGAGTCTGAGATTCTTCC	0.478													0	0	0	0.048971	0	68	164										C	61429948	G	C	61429948	3	2	10	1	0	0	0	0	1	0	0	0	2103	1291	45	1	290	1	C20orf20	20	61429948	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	1392	61429948	1595572	106	2704										
CHODL	140578	broad.mit.edu	37	chr21	19632552	19632552	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cccctgtagaaaagccttatCttacaaatcaaccaggagac	6	12	2	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr21:19632552C>G	uc002ykv.2	+	4	974	c.583C>G	c.(583-585)CTT>GTT	p.L195V	CHODL_uc002ykr.2_Missense_Mutation_p.L154V|CHODL_uc002yks.2_Missense_Mutation_p.L154V|CHODL_uc002ykt.2_Missense_Mutation_p.L154V|CHODL_uc002yku.2_Missense_Mutation_p.L154V	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	195	Extracellular (Potential).				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		AAAGCCTTATCTTACAAATCA	0.323													0	0	0	0.092188	0	36	59										G	19632552	C	G	19632552	3	3	10	1	0	0	0	0	1	0	0	0	3364	913	32	1	597	1	CHODL	21	19632552	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		19632552	28497343	107	2705										
PDXK	8566	broad.mit.edu	37	chr21	45161607	45161607	+	Frame_Shift_Del	DEL	G	G	-													0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	agctccaggagttgtacgaaGgcctgaggctgaacaacatg							TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr21:45161607delG	uc002zdm.3	+	3	400	c.202delG	c.(202-204)GGCfs	p.G68fs	PDXK_uc010gpj.2_Frame_Shift_Del_p.G68fs|PDXK_uc002zdn.3_Frame_Shift_Del_p.G68fs|PDXK_uc002zdq.3_5'UTR	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	68					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	GTTGTACGAAGGCCTGAGGCT	0.577																		16	27	---	---								-	45161607	G	-	45161607	7	5	10	1	0	1	0	1	0	0	0	0	11697	1000	35	0	212	0	PDXK	21	45161607	Frame_Shift_Del	DEL	G	TCGA-BT-A20P-01A-11D-A14W-08	25529055	45161607	2968288	108	2706										
BCL2L13	23786	broad.mit.edu	37	chr22	18171756	18171756	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tttgtcctatcttcagccttCaccagcacaggctttgaccg	7	14	3	1			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr22:18171756C>T	uc002zmw.2	+	4	452	c.234C>T	c.(232-234)TTC>TTT	p.F78F	BCL2L13_uc002zmu.2_Silent_p.F78F|BCL2L13_uc002zmv.2_Silent_p.F78F|BCL2L13_uc002zmx.2_Intron|BCL2L13_uc002zmy.2_Silent_p.F78F|BCL2L13_uc010gqy.2_Intron|BCL2L13_uc011agk.1_Intron|BCL2L13_uc010gqz.2_5'UTR|BCL2L13_uc002zmz.2_5'UTR	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	78					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTTCAGCCTTCACCAGCACAG	0.323													0	0	0	0.059317	0	33	31										T	18171756	C	T	18171756	2	4	10	1	0	0	0	0	0	0	0	1	1371	825	29	1		1	BCL2L13	22	18171756	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		18171756	33132810	109	2707										
MICAL3	57553	broad.mit.edu	37	chr22	18293495	18293495	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	tcgatgcagccgcttaagctCctcctgcttggcctgtctcc	9	16	1	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr22:18293495C>G	uc002zng.3	-	28	5883	c.5530G>C	c.(5530-5532)GAG>CAG	p.E1844Q	MICAL3_uc011agl.1_Missense_Mutation_p.E1760Q|MICAL3_uc010gre.1_RNA	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	1844	Potential.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		CGCTTAAGCTCCTCCTGCTTG	0.592													0	0	0	0.062417	0	20	21										G	18293495	C	G	18293495	3	3	10	1	0	0	0	0	1	0	0	0	9571	864	30	1	498	1	MICAL3	22	18293495	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	121739	18293495	33011071	110	2708										
DEPDC5	9681	broad.mit.edu	37	chr22	32266660	32266660	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	aatccatggacagaggcaacAgccagacctttgggaactcc	10	12	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr22:32266660A>C	uc003als.2	+	33	3464	c.3322A>C	c.(3322-3324)AGC>CGC	p.S1108R	DEPDC5_uc011als.1_Missense_Mutation_p.S1039R|DEPDC5_uc011alu.1_Missense_Mutation_p.S1139R|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.S1130R|DEPDC5_uc003alu.2_Missense_Mutation_p.S557R|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.S460R|DEPDC5_uc003alw.2_Missense_Mutation_p.S406R|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_Missense_Mutation_p.S134R|DEPDC5_uc011aly.1_5'UTR	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1108					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CAGAGGCAACAGCCAGACCTT	0.512													0	0	0	0.0333	0	15	32										C	32266660	A	C	32266660	3	2	10	1	0	0	0	0	1	0	0	0	4442	188	7	5	3536	5	DEPDC5	22	32266660	Missense_Mutation	SNP	A	TCGA-BT-A20P-01A-11D-A14W-08	13973165	32266660	19037906	111	2709										
H1F0	3005	broad.mit.edu	37	chr22	38201996	38201996	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	cggtcaagaaggccaagaagAagctggctgccacgcccaag	13	12	1	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr22:38201996A>C	uc003aty.2	+	1	883	c.445A>C	c.(445-447)AAG>CAG	p.K149Q	GCAT_uc003atz.2_5'Flank|GCAT_uc003aua.1_5'Flank	NM_005318	NP_005309	P07305	H10_HUMAN	H1 histone family, member 0	149					DNA fragmentation involved in apoptotic nuclear change|nucleosome assembly	actin cytoskeleton|Golgi apparatus|nucleoplasm|nucleosome	DNA binding				0	Melanoma(58;0.045)					GGCCAAGAAGAAGCTGGCTGC	0.547													0	0	0	0.059317	0	35	25										C	38201996	A	C	38201996	3	2	10	1	0	0	0	0	1	0	0	0	6920	247	9	5	447	5	H1F0	22	38201996	Missense_Mutation	SNP	A	TCGA-BT-A20P-01A-11D-A14W-08	5935336	38201996	13102570	112	2710										
MEI1	150365	broad.mit.edu	37	chr22	42126536	42126536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ccttgttagagttcctctttGagcatctttcttcttccagt	6	11	4	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chr22:42126536G>C	uc003baz.1	+	9	1016	c.991G>C	c.(991-993)GAG>CAG	p.E331Q	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc003bay.3_Missense_Mutation_p.E331Q|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	331							binding			central_nervous_system(1)|skin(1)	2						GTTCCTCTTTGAGCATCTTTC	0.438													0	0	0	0.0333	0	17	20										C	42126536	G	C	42126536	3	2	10	1	0	0	0	0	1	0	0	0	9465	1291	45	1	1025	1	MEI1	22	42126536	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	3924540	42126536	9178030	113	2711										
FAM9B	171483	broad.mit.edu	37	chrX	8995957	8995957	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	atctctttcagcctctctctCctaacacttctatattgttg	3	13	5	0			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chrX:8995957C>T	uc011mhu.1	-	6	533	c.444G>A	c.(442-444)AGG>AGA	p.R148R	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Silent_p.R188R	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	148						nucleus					0		Hepatocellular(5;0.219)				GCCTCTCTCTCCTAACACTTC	0.323													0	0	0	0.039052	0	37	51										T	8995957	C	T	8995957	2	4	10	1	0	0	0	0	0	0	0	1	5660	854	30	1		1	FAM9B	23	8995957	Silent	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08		8995957	146274603	114	2712										
SRPX	8406	broad.mit.edu	37	chrX	38079976	38079978	+	In_Frame_Del	DEL	GCA	GCA	-													0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	gctgcggctgggcgggacgcGcagcagcagcagcagcagca					rs72249350		TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chrX:38079976_38079978delGCA	uc004ddy.1	-	1	154_156	c.68_70delTGC	c.(67-72)CTGCGC>CGC	p.L23del	SRPX_uc004ddz.1_In_Frame_Del_p.L23del|SRPX_uc011mkh.1_In_Frame_Del_p.L23del|SRPX_uc011mki.1_In_Frame_Del_p.L23del	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane					0						GGCGGGACGCgcagcagcagcag	0.576											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						3	5	---	---								-	38079978	GCA	-	38079976	7	5	10	1	0	1	0	1	0	0	0	0	15163	1087	38	0	1364	0	SRPX	23	38079976	In_Frame_Del	DEL	GCA	TCGA-BT-A20P-01A-11D-A14W-08	29084019	38079976	117190584	115	2713										
WNK3	65267	broad.mit.edu	37	chrX	54259293	54259293	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	caaggactgggggcggcttcGaagtttgcttttgaaagatc	14	7	0	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chrX:54259293G>A	uc004dtd.1	-	21	5087	c.4648C>T	c.(4648-4650)CGA>TGA	p.R1550*	WNK3_uc004dtc.1_Nonsense_Mutation_p.R1597*	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1550					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GGGCGGCTTCGAAGTTTGCTT	0.408													0	0	0	0.048971	0	43	39										A	54259293	G	A	54259293	4	1	10	1	0	0	0	0	0	1	0	0	17376	1066	37	1	629	1	WNK3	23	54259293	Nonsense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	16179317	54259293	101011267	116	2714										
GPRASP1	9737	broad.mit.edu	37	chrX	101910483	101910483	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	ggacaaggtctgaggaagaaGaggtcattggtccctggttt	15	6	2	3			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chrX:101910483G>C	uc004ejj.3	+	5	2443	c.1642G>C	c.(1642-1644)GAG>CAG	p.E548Q	GPRASP1_uc004eji.3_Missense_Mutation_p.E548Q|GPRASP1_uc010nod.2_Missense_Mutation_p.E548Q	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	548	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TGAGGAAGAAGAGGTCATTGG	0.517													0	0	0	0.048971	0	68	16										C	101910483	G	C	101910483	3	2	10	1	0	0	0	0	1	0	0	0	6722	943	33	1	1644	1	GPRASP1	23	101910483	Missense_Mutation	SNP	G	TCGA-BT-A20P-01A-11D-A14W-08	47651190	101910483	53360077	117	2715										
MAGEC3	139081	broad.mit.edu	37	chrX	140953305	140953305	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.330508474576271	39	5.3101729682966e-11	3.07320261437909	4.85605413105413	1.48844571066793	0.000132975541941689	0.000751600889235634	26	attctgcctttcatcttgggCatctgagggaggtgaggctt	13	8	4	2			TCGA-BT-A20P-01A-11D-A14W-08	TCGA-BT-A20P-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c78a98-f45b-482b-a551-4f11b8c1ff8b	dd05d620-285e-4734-924b-c16361749fa4	g.chrX:140953305C>A	uc011mwp.1	+	2	172	c.172C>A	c.(172-174)CAT>AAT	p.H58N		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	58										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCATCTTGGGCATCTGAGGGA	0.512													1	0	1.17673e-23	0.048971	1.39246e-23	49	57										A	140953305	C	A	140953305	3	1	10	1	0	0	0	0	1	0	0	0	9182	710	25	4	178	4	MAGEC3	23	140953305	Missense_Mutation	SNP	C	TCGA-BT-A20P-01A-11D-A14W-08	39042822	140953305	14317255	118	2716										
VPS13D	55187	broad.mit.edu	37	chr1	12422812	12422812	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aggccgaggtcgatacattgAtacctgcatggtcatctttg	11	9	2	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:12422812A>T	uc001atv.2	+	51	10319	c.10178A>T	c.(10177-10179)GAT>GTT	p.D3393V	VPS13D_uc001atw.2_Missense_Mutation_p.D3368V|VPS13D_uc001atx.2_Missense_Mutation_p.D2580V	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3392					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CGATACATTGATACCTGCATG	0.428													0	0	0	0.048971	0	68	142										T	12422812	A	T	12422812	3	4	11	1	0	0	0	0	1	0	0	0	17189	333	12	5	10376	5	VPS13D	1	12422812	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08		12422812	236827809	1	2717										
C1orf144	26099	broad.mit.edu	37	chr1	16721628	16721628	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gtctcaaggcttcaaacagcGcagataaatgcaggcaagaa	10	9	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:16721628G>A	uc001aym.3	+	4	622	c.452G>A	c.(451-453)CGC>CAC	p.R151H	C1orf144_uc010ocb.1_Silent_p.A114A|C1orf144_uc001ayi.3_Missense_Mutation_p.R132H|C1orf144_uc001ayk.3_Missense_Mutation_p.R131H	NM_001114600	NP_001108072	Q7Z422	CA144_HUMAN	putative MAPK activating protein PM20,PM21	151											0		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.12e-05)|Kidney(64;0.00018)|KIRC - Kidney renal clear cell carcinoma(64;0.00267)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TTCAAACAGCGCAGATAAATG	0.582													0	0	0	0.021553	0	5	16										A	16721628	G	A	16721628	3	1	11	1	0	0	0	0	1	0	0	0	2002	1087	38	2	466	2	C1orf144	1	16721628	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	4298816	16721628	232528993	2	2718										
NBPF1	55672	broad.mit.edu	37	chr1	16918403	16918403	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gttacaaaacatttctctttGaggtttctgaactgctgttt	7	7	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:16918403G>C	uc009vos.1	-	7	1002	c.114C>G	c.(112-114)CTC>CTG	p.L38L	NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	38						cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ATTTCTCTTTGAGGTTTCTGA	0.468													0	0	0	0.048971	0	49	809										C	16918403	G	C	16918403	2	2	11	1	0	0	0	0	0	0	0	1	10192	1277	45	1		1	NBPF1	1	16918403	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	196775	16918403	232332218	3	2719										
UBR4	23352	broad.mit.edu	37	chr1	19441918	19441918	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttgtgacactggtacacattCtctccacagttgccacagac	7	13	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:19441918C>T	uc001bbi.2	-	74	11041	c.11037G>A	c.(11035-11037)GAG>GAA	p.E3679E	UBR4_uc001bbj.1_Silent_p.E94E	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3679					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGTACACATTCTCTCCACAGT	0.517													0	0	0	0.038395	0	17	35										T	19441918	C	T	19441918	2	4	11	1	0	0	0	0	0	0	0	1	16901	912	32	1		1	UBR4	1	19441918	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	2523515	19441918	229808703	4	2720										
ARID1A	8289	broad.mit.edu	37	chr1	27099094	27099097	+	Frame_Shift_Del	DEL	CAGT	CAGT	-													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	actccagcatccacaccacaCagtcagatccccccattgcc							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08			CAGT	-	CAGT	CAGT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:27099094_27099097delCAGT	uc001bmv.1	+	13	3883_3886	c.3510_3513delCAGT	c.(3508-3513)CACAGTfs	p.H1170fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.H1170fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.H1170fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.H787fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.H17fs|ARID1A_uc009vsm.1_5'Flank|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1170_1171					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCACACCACACAGTCAGATCCCCC	0.564			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													10	36	---	---								-	27099097	CAGT	-	27099094	7	5	11	1	0	1	0	1	0	0	0	0	913	477	17	0	3560	0	ARID1A	1	27099094	Frame_Shift_Del	DEL	CAGT	TCGA-BT-A20Q-01A-11D-A14W-08	7657176	27099094	222151527	5	2721										
PPIE	10450	broad.mit.edu	37	chr1	40214727	40214727	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctatgggaagaagttcgatGatgaaaactttatcctcaag	9	6	2	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:40214727G>A	uc001cds.1	+	8	704	c.661G>A	c.(661-663)GAT>AAT	p.D221N	PPIE_uc001cdt.1_Missense_Mutation_p.D155N|PPIE_uc010oiy.1_Missense_Mutation_p.D142N|PPIE_uc001cdu.1_RNA|PPIE_uc001cdv.2_Missense_Mutation_p.D221N|PPIE_uc001cdw.2_Missense_Mutation_p.D221N|PPIE_uc001cdx.1_Missense_Mutation_p.D137N	NM_006112	NP_006103	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E isoform 1	221	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding				0	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAAGTTCGATGATGAAAACTT	0.557													0	0	0	0.050027	0	31	32										A	40214727	G	A	40214727	3	1	11	1	0	0	0	0	1	0	0	0	12322	1290	45	1	691	1	PPIE	1	40214727	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	13115633	40214727	209035894	6	2722										
CDC14A	8556	broad.mit.edu	37	chr1	100920981	100920981	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cgagttgaaaatggtgacttCaactggattgttccaggaaa	11	6	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:100920981C>T	uc001dtg.3	+	8	1028	c.540C>T	c.(538-540)TTC>TTT	p.F180F	CDC14A_uc009web.2_RNA|CDC14A_uc010oui.1_Silent_p.F122F|CDC14A_uc001dte.3_Silent_p.F180F|CDC14A_uc001dtf.2_Silent_p.F180F|CDC14A_uc009wed.1_Intron|CDC14A_uc009wee.2_Silent_p.F180F	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	180	B.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		ATGGTGACTTCAACTGGATTG	0.303													0	0	0	0.108266	0	27	38										T	100920981	C	T	100920981	2	4	11	1	0	0	0	0	0	0	0	1	3056	825	29	1		1	CDC14A	1	100920981	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	60706254	100920981	148329640	7	2723										
C1orf161	126868	broad.mit.edu	37	chr1	116670903	116670903	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tttcaggtcatgaggcacctGaaggaggacatctggtgccc	13	10	3	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:116670903G>A	uc001egc.1	+	6	1063	c.798G>A	c.(796-798)CTG>CTA	p.L266L		NM_152367	NP_689580	Q8N8X9	MB213_HUMAN	hypothetical protein LOC126868	266											0	Lung SC(450;0.184)	all_cancers(81;0.00142)|all_lung(203;0.000139)|all_epithelial(167;0.000401)|Lung NSC(69;0.000705)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGAGGCACCTGAAGGAGGACA	0.587													0	0	0	0.009096	0	4	23										A	116670903	G	A	116670903	2	1	11	1	0	0	0	0	0	0	0	1	2009	1277	45	1		1	C1orf161	1	116670903	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	15749922	116670903	132579718	8	2724										
NBPF9	400818	broad.mit.edu	37	chr1	144619399	144619399	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gttgaggaggatgagaaagtGcagaaatcatctgcccccag	13	8	2	3	rs4067645	by1000genomes	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:144619399G>A	uc009wig.1	+	7	622	c.546G>A	c.(544-546)GTG>GTA	p.V182V	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Silent_p.V182V|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Silent_p.V113V|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Silent_p.V113V|NBPF9_uc010oyg.1_Silent_p.V147V|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	182	NBPF 1.					cytoplasm					0						ATGAGAAAGTGCAGAAATCAT	0.413													0	0	0	0.024245	0	5	230										A	144619399	G	A	144619399	2	1	11	1	0	0	0	0	0	0	0	1	10199	1306	46	2		2	NBPF9	1	144619399	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	27948496	144619399	104631222	9	2725										
PDE4DIP	9659	broad.mit.edu	37	chr1	144923818	144923818	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tttcagcaactcttcagtcaTgggctaggaagaaacggcaa	10	9	4	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:144923818T>C	uc001elw.3	-	6	931	c.640A>G	c.(640-642)ATG>GTG	p.M214V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.M280V|PDE4DIP_uc001emc.1_Missense_Mutation_p.M214V|PDE4DIP_uc001emd.1_Missense_Mutation_p.M214V|PDE4DIP_uc001emb.1_Missense_Mutation_p.M377V|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.M1V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	214					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTTCAGTCATGGGCTAGGAA	0.403			T	PDGFRB	MPD								0	0	0	0.043863	0	19	103										C	144923818	T	C	144923818	3	2	11	1	0	0	0	0	1	0	0	0	11643	1464	51	5	6566	5	PDE4DIP	1	144923818	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	304419	144923818	104326803	10	2726										
FAM63A	55793	broad.mit.edu	37	chr1	150974829	150974829	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ggagcatgcccttattgtctCtacttcaggcagtgtcccaa	9	12	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:150974829C>G	uc001ewf.2	-	3	1949	c.265G>C	c.(265-267)GAG>CAG	p.E89Q	FAM63A_uc001ewc.2_Intron|FAM63A_uc010pcm.1_5'UTR|FAM63A_uc001ewd.2_Intron|FAM63A_uc001ewe.2_Intron|FAM63A_uc010pcn.1_Missense_Mutation_p.E137Q|FAM63A_uc001ewg.2_Missense_Mutation_p.E89Q	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	89							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTTATTGTCTCTACTTCAGGC	0.582													0	0	0	0.069288	0	23	39										G	150974829	C	G	150974829	3	3	11	1	0	0	0	0	1	0	0	0	5596	922	32	1	1180	1	FAM63A	1	150974829	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	6051011	150974829	98275792	11	2727										
IQGAP3	128239	broad.mit.edu	37	chr1	156503868	156503868	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tggccacagccaccatgtctGagtactcgtccactgcaaaa	8	14	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:156503868G>C	uc001fpf.2	-	30	3881	c.3806C>G	c.(3805-3807)TCA>TGA	p.S1269*		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1269					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CACCATGTCTGAGTACTCGTC	0.607													0	0	0	0.030593	0	26	47										C	156503868	G	C	156503868	4	2	11	1	0	0	0	0	0	1	0	0	7816	1294	45	1	1125	1	IQGAP3	1	156503868	Nonsense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	5529039	156503868	92746753	12	2728										
OLFML2B	25903	broad.mit.edu	37	chr1	161968053	161968053	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ggtggctgcaggcctccgggTgacactggtcatcaggccgt	16	12	2	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:161968053T>A	uc001gbu.2	-	6	1460	c.1036A>T	c.(1036-1038)ACC>TCC	p.T346S	OLFML2B_uc010pkq.1_Missense_Mutation_p.T347S	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	346										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGCCTCCGGGTGACACTGGTC	0.567													0	0	0	0.083992	0	26	70										A	161968053	T	A	161968053	3	1	11	1	0	0	0	0	1	0	0	0	10858	1696	59	5	1228	5	OLFML2B	1	161968053	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	5464185	161968053	87282568	13	2729										
TNFSF4	7292	broad.mit.edu	37	chr1	173176222	173176222	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	caggagcagccccagtccctGaattacagaggccaccagca	10	15	0	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:173176222G>A	uc001giw.2	-	1	250	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	TNFSF4_uc001giv.2_5'Flank	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	32	Helical; Signal-anchor for type II membrane protein; (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						CCCAGTCCCTGAATTACAGAG	0.537													0	0	0	0.020292	0	15	35										A	173176222	G	A	173176222	4	1	11	1	0	0	0	0	0	1	0	0	16307	1299	45	1	469	1	TNFSF4	1	173176222	Nonsense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	11208169	173176222	76074399	14	2730										
HMCN1	83872	broad.mit.edu	37	chr1	186113383	186113383	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aggtactcagacaagagcaaGactttgtaataacccaccac	7	11	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:186113383G>A	uc001grq.1	+	90	14232	c.14003G>A	c.(14002-14004)AGA>AAA	p.R4668K	HMCN1_uc001grs.1_Missense_Mutation_p.R237K	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4668	TSP type-1 3.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACAAGAGCAAGACTTTGTAAT	0.478													0	0	0	0.080422	0	37	106										A	186113383	G	A	186113383	3	1	11	1	0	0	0	0	1	0	0	0	7220	942	33	1	14361	1	HMCN1	1	186113383	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	12937161	186113383	63137238	15	2731										
TPR	7175	broad.mit.edu	37	chr1	186324850	186324850	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agtggaaacagtctgtgatgTacttggacgttttggagttg	14	4	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:186324850T>C	uc001grv.2	-	16	2236	c.1939A>G	c.(1939-1941)ACA>GCA	p.T647A		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	647					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GTCTGTGATGTACTTGGACGT	0.398			T	NTRK1	papillary thyroid								0	0	0	0.041601	0	31	53										C	186324850	T	C	186324850	3	2	11	1	0	0	0	0	1	0	0	0	16413	1638	57	5	5296	5	TPR	1	186324850	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	211467	186324850	62925771	16	2732										
CACNA1S	779	broad.mit.edu	37	chr1	201060841	201060841	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ccgatgatggcatagatgatGaccataaagaggaccagcag	12	8	0	5			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:201060841G>C	uc001gvv.2	-	5	848	c.621C>G	c.(619-621)GTC>GTG	p.V207V		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	207	Helical; Name=S5 of repeat I; (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CATAGATGATGACCATAAAGA	0.562													0	0	0	0.105934	0	14	45										C	201060841	G	C	201060841	2	2	11	1	0	0	0	0	0	0	0	1	2547	1277	45	1		1	CACNA1S	1	201060841	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	14735991	201060841	48189780	17	2733										
ELF3	1999	broad.mit.edu	37	chr1	201981870	201981871	+	Frame_Shift_Ins	INS	-	-	T													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gccccctcccctggcagctcINStgacgtctccaccgcaggtg							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:201981870_201981871insT	uc001gxg.3	+	4	3773_3774	c.581_582insT	c.(580-582)TCTfs	p.S194fs	ELF3_uc001gxi.3_Frame_Shift_Ins_p.S194fs|ELF3_uc001gxh.3_Frame_Shift_Ins_p.S194fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	194					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CCTGGCAGCTCTGACGTCTCCA	0.663																		16	31	---	---								T	201981871	-	T	201981870	7	5	11	1	0	1	1	0	0	0	0	0	5055	913	32	0	595	0	ELF3	1	201981870	Frame_Shift_Ins	INS	-	TCGA-BT-A20Q-01A-11D-A14W-08	921029	201981870	47268751	18	2734										
PTPN7	5778	broad.mit.edu	37	chr1	202124738	202124738	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	acagacacggctctggggatCtaggaaataaaaatcagcag	11	8	3	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:202124738C>T	uc001gxm.1	-	5	523	c.392_splice	c.e5-1	p.N131_splice	PTPN7_uc001gxl.1_Splice_Site_p.N170_splice|PTPN7_uc001gxn.1_Splice_Site_p.N131_splice|PTPN7_uc010ppv.1_Splice_Site|PTPN7_uc010ppw.1_Splice_Site_p.N79_splice|PTPN7_uc010ppx.1_Splice_Site_p.N205_splice|PTPN7_uc010ppy.1_Intron|PTPN7_uc001gxo.1_Splice_Site_p.N83_splice	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type							cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						CTCTGGGGATCTAGGAAATAA	0.527													0	0	0	0.047766	0	7	20										T	202124738	C	T	202124738	5	4	11	1	0	0	0	0	0	0	1	0	12793	927	32	1	715	1	PTPN7	1	202124738	Splice_Site	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	142868	202124738	47125883	19	2735										
C4BPA	722	broad.mit.edu	37	chr1	207300089	207300089	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cgcaagccagatgtttcacaTggggaaatggtctctggatt	12	8	2	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:207300089T>A	uc001hfo.2	+	7	932	c.738T>A	c.(736-738)CAT>CAA	p.H246Q		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	246	Sushi 4.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						ATGTTTCACATGGGGAAATGG	0.378													0	0	0	0.069456	0	30	80										A	207300089	T	A	207300089	3	1	11	1	0	0	0	0	1	0	0	0	2249	1461	51	5	760	5	C4BPA	1	207300089	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	5175351	207300089	41950532	20	2736										
PTPN14	5784	broad.mit.edu	37	chr1	214557171	214557171	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tgcctgacccctcctcgggcGgtccctgctcccggagcgtg	13	18	0	1	rs139115216	by1000genomes	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:214557171G>A	uc001hkk.1	-	13	2298	c.2027C>T	c.(2026-2028)CCG>CTG	p.P676L	PTPN14_uc010pty.1_Missense_Mutation_p.P577L	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	676					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CTCCTCGGGCGGTCCCTGCTC	0.632													0	0	0	0.028581	0	16	27										A	214557171	G	A	214557171	3	1	11	1	0	0	0	0	1	0	0	0	12783	1116	39	2	1564	2	PTPN14	1	214557171	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	7257082	214557171	34693450	21	2737										
H3F3A	3020	broad.mit.edu	37	chr1	226252162	226252162	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gccctctactggaggggtgaAgaaacctcatcgttacaggt	12	10	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:226252162A>G	uc001hpw.2	+	2	225	c.110A>G	c.(109-111)AAG>AGG	p.K37R	H3F3A_uc010pvl.1_Missense_Mutation_p.K37R	NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	37					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding				0	Breast(184;0.179)			GBM - Glioblastoma multiforme(131;0.203)		GGAGGGGTGAAGAAACCTCAT	0.448											OREG0014293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.047766	0	9	28										G	226252162	A	G	226252162	3	3	11	1	0	0	0	0	1	0	0	0	6933	72	3	5	112	5	H3F3A	1	226252162	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08	11694991	226252162	22998459	22	2738										
PSEN2	5664	broad.mit.edu	37	chr1	227071519	227071519	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ctgaccctcaaatacggagcGaagcacgtgatcatgctgtt	10	11	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:227071519G>A	uc009xeo.1	+	5	682	c.255G>A	c.(253-255)GCG>GCA	p.A85A	PSEN2_uc009xep.1_Silent_p.A85A|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	85	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				AATACGGAGCGAAGCACGTGA	0.582													0	0	0	0.049695	0	19	50										A	227071519	G	A	227071519	2	1	11	1	0	0	0	0	0	0	0	1	12651	1045	37	1		1	PSEN2	1	227071519	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	819357	227071519	22179102	23	2739										
TSNAX	7257	broad.mit.edu	37	chr1	231696991	231696995	+	Frame_Shift_Del	DEL	AAAAT	AAAAT	-													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gactgaagacaatgggaaagAaaataaaactgtgagaattt							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr1:231696991_231696995delAAAAT	uc001huw.2	+	5	643_647	c.485_489delAAAAT	c.(484-489)GAAAATfs	p.E162fs	TSNAX-DISC1_uc010pwe.1_5'UTR|TSNAX-DISC1_uc010pwf.1_Intron|TSNAX-DISC1_uc010pwg.1_Intron|TSNAX-DISC1_uc010pwh.1_5'UTR|TSNAX-DISC1_uc010pwi.1_5'UTR|TSNAX-DISC1_uc010pwj.1_5'UTR|TSNAX-DISC1_uc010pwk.1_5'UTR|TSNAX-DISC1_uc010pwl.1_Intron	NM_005999	NP_005990	Q99598	TSNAX_HUMAN	translin-associated factor X	162_163	Interaction with C1D.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus|perinuclear region of cytoplasm	protein transporter activity|sequence-specific DNA binding				0		all_cancers(173;0.0395)|Acute lymphoblastic leukemia(190;3.76e-06)|Prostate(94;0.116)				AATGGGAAAGAAAATAAAACTGTGA	0.273																		10	33	---	---								-	231696995	AAAAT	-	231696991	7	5	11	1	0	1	0	1	0	0	0	0	16628	246	9	0	503	0	TSNAX	1	231696991	Frame_Shift_Del	DEL	AAAAT	TCGA-BT-A20Q-01A-11D-A14W-08	4625472	231696991	17553630	24	2740										
GGCX	2677	broad.mit.edu	37	chr2	85785670	85785670	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agaaacacataccagtatggCagcaggaataacacacagct	8	10	0	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:85785670C>T	uc002sps.2	-	4	538	c.432G>A	c.(430-432)CTG>CTA	p.L144L	GGCX_uc010yss.1_Silent_p.L16L|GGCX_uc010yst.1_Silent_p.L87L	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	144	Helical; (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	ACCAGTATGGCAGCAGGAATA	0.493													0	0	0	0.076483	0	24	44										T	85785670	C	T	85785670	2	4	11	1	0	0	0	0	0	0	0	1	6356	697	25	2		2	GGCX	2	85785670	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		85785670	157413703	25	2741										
GPR39	2863	broad.mit.edu	37	chr2	133174772	133174772	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tggggaacagcgccaccattCgggtcacccaggtgctgcag	14	13	1	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:133174772C>T	uc002ttl.2	+	1	626	c.157C>T	c.(157-159)CGG>TGG	p.R53W		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	53	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						CGCCACCATTCGGGTCACCCA	0.537													0	0	0	0.049695	0	19	32										T	133174772	C	T	133174772	3	4	11	1	0	0	0	0	1	0	0	0	6693	875	31	1	159	1	GPR39	2	133174772	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	47389102	133174772	110024601	26	2742										
LRP1B	53353	broad.mit.edu	37	chr2	141272335	141272335	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	caaattggttccaagagcaaGaagaatctaggaaacaaaca	8	7	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:141272335G>T	uc002tvj.1	-	51	9128	c.8156C>A	c.(8155-8157)TCT>TAT	p.S2719Y		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2719	Extracellular (Potential).|LDL-receptor class A 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAAGAGCAAGAAGAATCTAG	0.284										TSP Lung(27;0.18)			1	0	7.03913e-09	0.09319	7.33447e-09	13	26										T	141272335	G	T	141272335	3	4	11	1	0	0	0	0	1	0	0	0	8955	942	33	3	5807	3	LRP1B	2	141272335	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	8097563	141272335	101927038	27	2743										
IFIH1	64135	broad.mit.edu	37	chr2	163174805	163174806	+	Frame_Shift_Ins	INS	-	-	CC													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aaattctcgtctgtggaataINScccattcgacatctttcttt							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:163174805_163174806insCC	uc002uce.2	-	1	234_235	c.12_13insGG	c.(10-15)GGGTATfs	p.G4fs	IFIH1_uc002ucf.2_Frame_Shift_Ins_p.G4fs	NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	4_5					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						TCTGTGGAATACCCATTCGACA	0.53																		22	62	---	---								CC	163174806	-	CC	163174805	7	5	11	1	0	1	1	0	0	0	0	0	7520	391	14	0	3128	0	IFIH1	2	163174805	Frame_Shift_Ins	INS	-	TCGA-BT-A20Q-01A-11D-A14W-08	21902470	163174805	80024568	28	2744										
SP3	6670	broad.mit.edu	37	chr2	174783487	174783487	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gagctgccactcttcaggatCaggttcttcttccttgatcc	8	13	5	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:174783487C>T	uc002uig.2	-	5	1830	c.1666G>A	c.(1666-1668)GAT>AAT	p.D556N	SP3_uc002uie.2_Missense_Mutation_p.D488N|SP3_uc002uif.2_Missense_Mutation_p.D503N|SP3_uc010zel.1_Missense_Mutation_p.D553N	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	556	Repressor domain.				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TCTTCAGGATCAGGTTCTTCT	0.403													0	0	0	0.0333	0	17	39										T	174783487	C	T	174783487	3	4	11	1	0	0	0	0	1	0	0	0	14965	826	29	1	691	1	SP3	2	174783487	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	11608682	174783487	68415886	29	2745										
TTN	7273	broad.mit.edu	37	chr2	179638034	179638034	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agagtgggacagctcaacctCaaacaccacattttgagttt	8	10	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:179638034C>G	uc010zfg.1	-	33	7881	c.7657G>C	c.(7657-7659)GAG>CAG	p.E2553Q	TTN_uc010zfh.1_Missense_Mutation_p.E2507Q|TTN_uc010zfi.1_Missense_Mutation_p.E2507Q|TTN_uc010zfj.1_Missense_Mutation_p.E2507Q|TTN_uc002unb.2_Missense_Mutation_p.E2553Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2553							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCTCAACCTCAAACACCACA	0.353													0	0	0	0.049695	0	18	33										G	179638034	C	G	179638034	3	3	11	1	0	0	0	0	1	0	0	0	16732	835	29	1	103651	1	TTN	2	179638034	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	4854547	179638034	63561339	30	2746										
COL5A2	1290	broad.mit.edu	37	chr2	189953486	189953486	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttcatccaacccagccatttGagctgaaaacggctgtaaaa	7	11	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:189953486G>C	uc002uqk.2	-	8	855	c.580C>G	c.(580-582)CAA>GAA	p.Q194E	COL5A2_uc010frx.2_5'Flank	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	194					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGCCATTTGAGCTGAAAAC	0.378													0	0	0	0.108266	0	25	75										C	189953486	G	C	189953486	3	2	11	1	0	0	0	0	1	0	0	0	3697	1299	45	1	4107	1	COL5A2	2	189953486	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	10315452	189953486	53245887	31	2747										
ANKAR	150709	broad.mit.edu	37	chr2	190593544	190593544	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gagcagtgggatccatttgtAttggtttgtatacttattct	10	5	1	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:190593544A>G	uc002uqw.1	+	14	2977	c.2977A>G	c.(2977-2979)ATT>GTT	p.I993V	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Missense_Mutation_p.I160V	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1064						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ATCCATTTGTATTGGTTTGTA	0.393													0	0	0	0.037714	0	31	48										G	190593544	A	G	190593544	3	3	11	1	0	0	0	0	1	0	0	0	623	449	16	5	3244	5	ANKAR	2	190593544	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08	640058	190593544	52605829	32	2748										
GTF3C3	9330	broad.mit.edu	37	chr2	197639909	197639909	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gtctctcgatactttaataaGataaagatgcctctctccag	6	10	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr2:197639909G>C	uc002uts.2	-	13	1852	c.1762C>G	c.(1762-1764)CTT>GTT	p.L588V	GTF3C3_uc010zgu.1_Missense_Mutation_p.L559V	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	588						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						ACTTTAATAAGATAAAGATGC	0.333													0	0	0	0.024245	0	14	37										C	197639909	G	C	197639909	3	2	11	1	0	0	0	0	1	0	0	0	6874	942	33	1	922	1	GTF3C3	2	197639909	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	7046365	197639909	45559464	33	2749										
CCDC36	339834	broad.mit.edu	37	chr3	49249260	49249260	+	Nonsense_Mutation	SNP	C	C	A													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agagatgctcagtattccttCaggctctgggtaagttttct							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:49249260C>A	uc003cwk.2	+	4	434	c.47C>A	c.(46-48)TCA>TAA	p.S16*	CCDC36_uc003cwl.3_Nonsense_Mutation_p.S16*|CCDC36_uc011bck.1_Nonsense_Mutation_p.S16*|CCDC36_uc010hkt.2_RNA	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	16										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		AGTATTCCTTCAGGCTCTGGG	0.239													1	0	3.7963e-18	0.083992	4.0117e-18	22	63										A	49249260	C	A	49249260	4	1	11	1	0	0	0	0	0	1	0	0	2808	838	29	3	49	3	CCDC36	3	49249260	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		49249260	148773170	34	2750	17	2								
CCDC36	339834	broad.mit.edu	37	chr3	49249266	49249266	+	Missense_Mutation	SNP	C	C	T													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gctcagtattccttcaggctCtgggtaagttttctggttat							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:49249266C>T	uc003cwk.2	+	4	440	c.53C>T	c.(52-54)TCT>TTT	p.S18F	CCDC36_uc003cwl.3_Missense_Mutation_p.S18F|CCDC36_uc011bck.1_Missense_Mutation_p.S18F|CCDC36_uc010hkt.2_RNA	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	18										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCTTCAGGCTCTGGGTAAGTT	0.229													0	0	0	0.069288	0	21	61										T	49249266	C	T	49249266	3	4	11	1	0	0	0	0	1	0	0	0	2808	913	32	1	55	1	CCDC36	3	49249266	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	6	49249266	148773164	35	2751	17	2								
DOCK3	1795	broad.mit.edu	37	chr3	51393912	51393912	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctcggtggtttgaagtggaGaggagggaactggtgagaca	18	4	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:51393912G>C	uc011bds.1	+	43	4514	c.4491G>C	c.(4489-4491)GAG>GAC	p.E1497D		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1497	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTGAAGTGGAGAGGAGGGAAC	0.542													0	0	0	0.028581	0	16	47										C	51393912	G	C	51393912	3	2	11	1	0	0	0	0	1	0	0	0	4688	933	33	1	4661	1	DOCK3	3	51393912	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	2144646	51393912	146628518	36	2752										
ARHGEF3	50650	broad.mit.edu	37	chr3	56787589	56787589	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctccttgggaaagctcaaaGatcgcctgcaaggaaagata	10	9	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:56787589G>C	uc003dig.2	-	4	550	c.381C>G	c.(379-381)ATC>ATG	p.I127M	ARHGEF3_uc011bew.1_Missense_Mutation_p.I127M|ARHGEF3_uc003dih.2_Missense_Mutation_p.I159M|ARHGEF3_uc011bev.1_Missense_Mutation_p.I98M|ARHGEF3_uc003dif.2_Missense_Mutation_p.I133M|ARHGEF3_uc010hmy.1_Translation_Start_Site|ARHGEF3_uc003dii.2_Missense_Mutation_p.I127M	NM_019555	NP_062455	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor 3 isoform	127	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		AAAGCTCAAAGATCGCCTGCA	0.368													0	0	0	0.041601	0	27	83										C	56787589	G	C	56787589	3	2	11	1	0	0	0	0	1	0	0	0	904	932	33	1	1227	1	ARHGEF3	3	56787589	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	5393677	56787589	141234841	37	2753										
ARL13B	200894	broad.mit.edu	37	chr3	93761858	93761858	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	atgtattttattttttgttaGaatgaaggaaaacttgaaag	8	1	0	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:93761858G>C	uc003drc.2	+	7	1085	c.799_splice	c.e7-1	p.N267_splice	ARL13B_uc010hop.2_Splice_Site_p.N118_splice|ARL13B_uc003drd.2_Splice_Site_p.N160_splice|ARL13B_uc003dre.2_Splice_Site_p.N252_splice|ARL13B_uc003drf.2_Splice_Site_p.N267_splice|ARL13B_uc003drg.2_Splice_Site_p.N164_splice	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1								GTP binding				0						TTTTTTGTTAGAATGAAGGAA	0.313													0	0	0	0.004672	0	2	6										C	93761858	G	C	93761858	5	2	11	1	0	0	0	0	0	0	1	0	929	956	33	1	824	1	ARL13B	3	93761858	Splice_Site	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	36974269	93761858	104260572	38	2754			1	9		2	2	23	G		8.669795e-05
ARL13B	200894	broad.mit.edu	37	chr3	93761880	93761880	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	atgaaggaaaacttgaaagaGagaaaaaaaaccaaaaaatg	8	3	0	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:93761880G>C	uc003drc.2	+	7	1106	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	ARL13B_uc010hop.2_Missense_Mutation_p.E125Q|ARL13B_uc003drd.2_Missense_Mutation_p.E167Q|ARL13B_uc003dre.2_Missense_Mutation_p.E259Q|ARL13B_uc003drf.2_Missense_Mutation_p.E274Q|ARL13B_uc003drg.2_Missense_Mutation_p.E171Q	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	274							GTP binding				0						ACTTGAAAGAGAGAAAAAAAA	0.328													0	0	0	0.009096	0	4	10										C	93761880	G	C	93761880	3	2	11	1	0	0	0	0	1	0	0	0	929	943	33	1	846	1	ARL13B	3	93761880	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	22	93761880	104260550	39	2755			1	9		2	2	23	G		8.669795e-05
SGEF	26084	broad.mit.edu	37	chr3	153840100	153840100	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agtacagggctgcctctcctCgacttcgacggcccaagtca	10	15	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:153840100C>G	uc011bog.1	+	2	530	c.319C>G	c.(319-321)CGA>GGA	p.R107G	uc003ezu.1_5'Flank|SGEF_uc011boh.1_Missense_Mutation_p.R107G	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	107	Pro-rich.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGCCTCTCCTCGACTTCGACG	0.687													0	0	0	0.021553	0	5	17										G	153840100	C	G	153840100	3	3	11	1	0	0	0	0	1	0	0	0	14205	876	31	1	321	1	SGEF	3	153840100	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	60078220	153840100	44182330	40	2756										
VPS8	23355	broad.mit.edu	37	chr3	184557485	184557485	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aatcttcccttttgttttcaGgcagtatccagtctgatagc	7	10	3	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:184557485G>A	uc003fpb.1	+	7	652	c.481_splice	c.e7-1	p.A161_splice	VPS8_uc010hyd.1_Splice_Site_p.A161_splice|VPS8_uc003fpc.1_3'UTR	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b								zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TTTGTTTTCAGGCAGTATCCA	0.358													0	0	0	0.038147	0	7	12										A	184557485	G	A	184557485	5	1	11	1	0	0	0	0	0	0	1	0	17215	1014	35	2	502	2	VPS8	3	184557485	Splice_Site	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	30717385	184557485	13464945	41	2757										
TFRC	7037	broad.mit.edu	37	chr3	195794923	195794923	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	atgtccaaagaatgaaagttCtgcgttaacaatgggaaatt	9	5	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr3:195794923C>T	uc003fvz.3	-	8	1163	c.880G>A	c.(880-882)GAA>AAA	p.E294K	TFRC_uc003fwa.3_Missense_Mutation_p.E294K|TFRC_uc010hzy.2_Missense_Mutation_p.E213K|TFRC_uc011btr.1_Missense_Mutation_p.E12K	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	294	Extracellular (Potential).|PA.				cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AATGAAAGTTCTGCGTTAACA	0.353			T	BCL6	NHL								0	0	0	0.02938	0	7	33										T	195794923	C	T	195794923	3	4	11	1	0	0	0	0	1	0	0	0	15809	922	32	1	1450	1	TFRC	3	195794923	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	11237438	195794923	2227507	42	2758										
HTRA3	94031	broad.mit.edu	37	chr4	8288305	8288305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cagacacccgctgtttggccGcaacgtgcccctgtccagcg	11	17	0	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:8288305G>A	uc003gla.2	+	3	707	c.503G>A	c.(502-504)CGC>CAC	p.R168H	HTRA3_uc003gkz.2_Missense_Mutation_p.R168H	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	168					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						CTGTTTGGCCGCAACGTGCCC	0.657													0	0	0	0.043863	0	16	64										A	8288305	G	A	8288305	3	1	11	1	0	0	0	0	1	0	0	0	7455	1087	38	2	513	2	HTRA3	4	8288305	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		8288305	182865971	43	2759										
METAP1	23173	broad.mit.edu	37	chr4	99982412	99982412	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tggtcacagacactggctgtGaaatcctaacccggcgactt	10	12	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:99982412G>C	uc003huf.3	+	11	1222	c.1105G>C	c.(1105-1107)GAA>CAA	p.E369Q	METAP1_uc003hug.2_RNA|METAP1_uc010ild.2_RNA	NM_015143	NP_055958	P53582	AMPM1_HUMAN	methionyl aminopeptidase 1	369					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis|regulation of translation	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;3.12e-07)		CACTGGCTGTGAAATCCTAAC	0.512													0	0	0	0.076483	0	25	59										C	99982412	G	C	99982412	3	2	11	1	0	0	0	0	1	0	0	0	9486	1291	45	1	1147	1	METAP1	4	99982412	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	91694107	99982412	91171864	44	2760										
TET2	54790	broad.mit.edu	37	chr4	106156496	106156496	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttcccagagtcctaatccatCtacacatgtatgcagccctt	5	14	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:106156496C>G	uc003hxk.2	+	3	1783	c.1397C>G	c.(1396-1398)TCT>TGT	p.S466C	TET2_uc011cez.1_Missense_Mutation_p.S487C|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.S466C|TET2_uc003hxi.1_Missense_Mutation_p.S466C	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	466					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CCTAATCCATCTACACATGTA	0.458			Mis N|F		MDS								0	0	0	0.09319	0	13	35										G	106156496	C	G	106156496	3	3	11	1	0	0	0	0	1	0	0	0	15767	913	32	1	1399	1	TET2	4	106156496	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	6174084	106156496	84997780	45	2761										
TET2	54790	broad.mit.edu	37	chr4	106156625	106156625	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tgagaaaacaagaccaatgtCagaacacctcaagcataacc	6	11	2	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:106156625C>G	uc003hxk.2	+	3	1912	c.1526C>G	c.(1525-1527)TCA>TGA	p.S509*	TET2_uc011cez.1_Nonsense_Mutation_p.S530*|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Nonsense_Mutation_p.S509*|TET2_uc003hxi.1_Nonsense_Mutation_p.S509*	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	509					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.S509*(3)		haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AGACCAATGTCAGAACACCTC	0.433			Mis N|F		MDS								0	0	0	0.069234	0	11	37										G	106156625	C	G	106156625	4	3	11	1	0	0	0	0	0	1	0	0	15767	838	29	1	1528	1	TET2	4	106156625	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	129	106156625	84997651	46	2762										
RAPGEF2	9693	broad.mit.edu	37	chr4	160253617	160253617	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttttagtatttaaagaacttCtaacaagattgtcagaagag	7	4	2	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:160253617C>T	uc003iqg.3	+	11	1730	c.1420C>T	c.(1420-1422)CTA>TTA	p.L474L		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	474					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TAAAGAACTTCTAACAAGATT	0.358													0	0	0	0.049695	0	18	43										T	160253617	C	T	160253617	2	4	11	1	0	0	0	0	0	0	0	1	13044	912	32	1		1	RAPGEF2	4	160253617	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	54096992	160253617	30900659	47	2763										
CPE	1363	broad.mit.edu	37	chr4	166414359	166414359	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aaggatttgtccgagaccttCaaggtaacccaattgcgaat	9	9	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:166414359C>T	uc003irg.3	+	7	1427	c.1150C>T	c.(1150-1152)CAA>TAA	p.Q384*		NM_001873	NP_001864	P16870	CBPE_HUMAN	carboxypeptidase E preproprotein	384					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCGAGACCTTCAAGGTAACCC	0.408											OREG0016391	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.028581	0	13	36										T	166414359	C	T	166414359	4	4	11	1	0	0	0	0	0	1	0	0	3799	827	29	1	1176	1	CPE	4	166414359	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	6160742	166414359	24739917	48	2764										
UFSP2	55325	broad.mit.edu	37	chr4	186334999	186334999	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tttgaaatagggtctgtcgtGaggcagattgaaaagatcat	12	4	2	5			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr4:186334999G>T	uc003ixo.2	-	7	829	c.712C>A	c.(712-714)CAC>AAC	p.H238N	UFSP2_uc003ixn.2_Missense_Mutation_p.H128N|UFSP2_uc003ixq.2_Missense_Mutation_p.H128N|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	238						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		GGTCTGTCGTGAGGCAGATTG	0.333													1	0	1.1804e-14	0.0918	1.23858e-14	26	31										T	186334999	G	T	186334999	3	4	11	1	0	0	0	0	1	0	0	0	16935	1290	45	3	721	3	UFSP2	4	186334999	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	19920640	186334999	4819277	49	2765										
NIPBL	25836	broad.mit.edu	37	chr5	36985880	36985880	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agttcaaaaactgataaactAgaacgaaaacacaggcatga	7	7	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:36985880A>G	uc003jkl.3	+	10	3097	c.2598A>G	c.(2596-2598)CTA>CTG	p.L866L	NIPBL_uc003jkk.3_Silent_p.L866L|NIPBL_uc003jkm.1_Silent_p.L745L	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	866					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTGATAAACTAGAACGAAAAC	0.413													0	0	0	0.020292	0	14	20										G	36985880	A	G	36985880	2	3	11	1	0	0	0	0	0	0	0	1	10428	407	15	5		5	NIPBL	5	36985880	Silent	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08		36985880	143929380	50	2766										
PCDHA6	56142	broad.mit.edu	37	chr5	140209470	140209470	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gcgaaggtgcgcgcagttgaCgccgactcaggctacaacgc	14	13	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:140209470C>T	uc003lho.2	+	1	1821	c.1794C>T	c.(1792-1794)GAC>GAT	p.D598D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.D598D	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	598	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCAGTTGACGCCGACTCAG	0.667													0	0	0	0.009096	0	3	54										T	140209470	C	T	140209470	2	4	11	1	0	0	0	0	0	0	0	1	11528	535	19	2		2	PCDHA6	5	140209470	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	103223590	140209470	40705790	51	2767										
IL17B	27190	broad.mit.edu	37	chr5	148754143	148754143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ccggcaggtccacggggataCggctggggtcgtggttgatg	19	9	0	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:148754143C>T	uc003lqo.2	-	3	382	c.332G>A	c.(331-333)CGT>CAT	p.R111H		NM_014443	NP_055258	Q9UHF5	IL17B_HUMAN	interleukin 17B precursor	111					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGGGATACGGCTGGGGTC	0.627													0	0	0	0.021553	0	6	21										T	148754143	C	T	148754143	3	4	11	1	0	0	0	0	1	0	0	0	7635	536	19	2	214	2	IL17B	5	148754143	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	8544673	148754143	32161117	52	2768										
SYNPO	11346	broad.mit.edu	37	chr5	150028061	150028061	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tgtcaaccaaaaccttgcctCgcccagtgccacgctcacca	6	18	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr5:150028061C>T	uc003lsn.2	+	3	1330	c.956C>T	c.(955-957)TCG>TTG	p.S319L	SYNPO_uc003lso.3_Missense_Mutation_p.S75L|SYNPO_uc003lsp.2_Missense_Mutation_p.S75L	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	319					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACCTTGCCTCGCCCAGTGCC	0.607													0	0	0	0.11126	0	44	93										T	150028061	C	T	150028061	3	4	11	1	0	0	0	0	1	0	0	0	15453	893	31	1	962	1	SYNPO	5	150028061	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	1273918	150028061	30887199	53	2769										
HIST1H4L	8368	broad.mit.edu	37	chr6	27841112	27841114	+	In_Frame_Del	DEL	AAG	AAG	-													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	acattctccaaaaacactttAagaactccgcgtgtctcctc							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:27841112_27841114delAAG	uc003njz.2	-	1	176_178	c.175_177delCTT	c.(175-177)CTTdel	p.L59del	HIST1H3I_uc003njy.2_5'Flank	NM_003546	NP_003537	P62805	H4_HUMAN	histone cluster 1, H4l	59					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)|breast(1)	2						AAAACACTTTAAGAACTCCGCGT	0.552																		12	41	---	---								-	27841114	AAG	-	27841112	7	5	11	1	0	1	0	1	0	0	0	0	7176	349	13	0	138	0	HIST1H4L	6	27841112	In_Frame_Del	DEL	AAG	TCGA-BT-A20Q-01A-11D-A14W-08		27841112	143273955	54	2770										
KIAA1949	170954	broad.mit.edu	37	chr6	30653297	30653297	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cctccagtcccgagcctccaGaggcctcaggctcaactctt	8	18	3	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:30653297G>T	uc003nra.2	-	2	730	c.499C>A	c.(499-501)CTG>ATG	p.L167M	KIAA1949_uc003nrb.3_Missense_Mutation_p.L167M	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	167						cytoplasm|cytoskeleton	actin binding				0						CGAGCCTCCAGAGGCCTCAGG	0.602													1	0	1.40369e-38	0.048971	1.49392e-38	65	127										T	30653297	G	T	30653297	3	4	11	1	0	0	0	0	1	0	0	0	8263	933	33	3	1354	3	KIAA1949	6	30653297	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	2812185	30653297	140461770	55	2771										
RNF5	6048	broad.mit.edu	37	chr6	32148014	32148014	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctctcccacaggtgtggatCtgggacagggtcacccagcc	12	14	3	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:32148014C>T	uc003oaj.3	+	6	581	c.454C>T	c.(454-456)CTG>TTG	p.L152L	AGPAT1_uc003oaf.2_5'Flank|AGPAT1_uc003oag.2_5'Flank|AGPAT1_uc003oah.2_5'Flank	NM_006913	NP_008844	Q99942	RNF5_HUMAN	ring finger protein 5	152					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						AGGTGTGGATCTGGGACAGGG	0.562													0	0	0	0.048971	0	83	175										T	32148014	C	T	32148014	2	4	11	1	0	0	0	0	0	0	0	1	13497	912	32	1		1	RNF5	6	32148014	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	1494717	32148014	138967053	56	2772										
COL19A1	1310	broad.mit.edu	37	chr6	70875870	70875870	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tgggaaacccggaccacctgGaccacctgtgagttgttcta	11	12	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:70875870G>C	uc003pfc.1	+	37	2555	c.2438G>C	c.(2437-2439)GGA>GCA	p.G813A	COL19A1_uc010kam.1_Missense_Mutation_p.G709A	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	813	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGACCACCTGGACCACCTGTG	0.428													0	0	0	0.004672	0	3	136										C	70875870	G	C	70875870	3	2	11	1	0	0	0	0	1	0	0	0	3676	1174	41	1	2580	1	COL19A1	6	70875870	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	38727856	70875870	100239197	57	2773										
B3GAT2	135152	broad.mit.edu	37	chr6	71665793	71665793	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cgccgcgtcctccaccaggaTccagtgcagctgcgccacct	10	19	0	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:71665793T>C	uc003pfv.2	-	1	996	c.340A>G	c.(340-342)ATC>GTC	p.I114V	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.I114V	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	114	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TCCACCAGGATCCAGTGCAGC	0.721													0	0	0	0.021553	0	5	10										C	71665793	T	C	71665793	3	2	11	1	0	0	0	0	1	0	0	0	1254	1435	50	5	647	5	B3GAT2	6	71665793	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	789923	71665793	99449274	58	2774										
LAMA2	3908	broad.mit.edu	37	chr6	129691106	129691106	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agggcaatctgaatacactcGtgaccgaaatgaacgagctg	11	9	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:129691106G>A	uc003qbn.2	+	34	5035	c.4930G>A	c.(4930-4932)GTG>ATG	p.V1644M	LAMA2_uc003qbo.2_Missense_Mutation_p.V1644M	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1644	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAATACACTCGTGACCGAAAT	0.433													0	0	0	0.034045	0	29	31										A	129691106	G	A	129691106	3	1	11	1	0	0	0	0	1	0	0	0	8606	1145	40	2	5064	2	LAMA2	6	129691106	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	58025313	129691106	41423961	59	2775										
SYNE1	23345	broad.mit.edu	37	chr6	152668238	152668238	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tgagtagctgtcctttgtgcCctgcagatgagcatgcacgt	12	10	0	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:152668238C>T	uc010kiw.2	-	73	12636	c.12034G>A	c.(12034-12036)GGC>AGC	p.G4012S	SYNE1_uc003qot.3_Missense_Mutation_p.G3941S|SYNE1_uc003qou.3_Missense_Mutation_p.G4012S|SYNE1_uc010kja.1_Missense_Mutation_p.G717S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4012	Spectrin 10.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCTTTGTGCCCTGCAGATGA	0.493										HNSCC(10;0.0054)			0	0	0	0.020292	0	12	39										T	152668238	C	T	152668238	3	4	11	1	0	0	0	0	1	0	0	0	15442	623	22	2	14728	2	SYNE1	6	152668238	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	22977132	152668238	18446829	60	2776										
LPA	4018	broad.mit.edu	37	chr6	161007642	161007642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctcagcatctggattcctgCagtagttcctggtcaggcca	10	12	3	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr6:161007642C>T	uc003qtl.2	-	26	4088	c.3968G>A	c.(3967-3969)TGC>TAC	p.C1323Y		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3831	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGGATTCCTGCAGTAGTTCCT	0.483													0	0	0	0.038395	0	19	47										T	161007642	C	T	161007642	3	4	11	1	0	0	0	0	1	0	0	0	8903	710	25	2	2214	2	LPA	6	161007642	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	8339404	161007642	10107425	61	2777										
CRHR2	1395	broad.mit.edu	37	chr7	30721547	30721547	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tcacgggtcgtgttgtacttGacgccgttgaagtactcggg	14	9	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:30721547G>C	uc003tbn.2	-	2	457	c.213C>G	c.(211-213)GTC>GTG	p.V71V	CRHR2_uc010kvw.1_Silent_p.V71V|CRHR2_uc010kvx.1_Silent_p.V71V|CRHR2_uc010kvy.1_5'UTR|CRHR2_uc003tbo.2_Silent_p.V57V|CRHR2_uc003tbp.2_Silent_p.V98V|CRHR2_uc010kvz.1_RNA|CRHR2_uc003tbq.1_RNA	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	71	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						TGTTGTACTTGACGCCGTTGA	0.647													0	0	0	0.105934	0	10	17										C	30721547	G	C	30721547	2	2	11	1	0	0	0	0	0	0	0	1	3872	1277	45	1		1	CRHR2	7	30721547	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		30721547	128417116	62	2778										
MRPS17	51373	broad.mit.edu	37	chr7	56022649	56022649	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gctcacgatgcccttcagcaGtgcacagttggggatattgt	12	10	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:56022649G>A	uc003trd.2	+	3	201	c.171G>A	c.(169-171)CAG>CAA	p.Q57Q	MRPS17_uc003trb.2_Silent_p.Q152Q	NM_015969	NP_057053	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17 precursor	57					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCCTTCAGCAGTGCACAGTTG	0.443													0	0	0	0.048971	0	88	212										A	56022649	G	A	56022649	2	1	11	1	0	0	0	0	0	0	0	1	9827	1020	36	2		2	MRPS17	7	56022649	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	25301102	56022649	103116014	63	2779										
TBXAS1	6916	broad.mit.edu	37	chr7	139636073	139636073	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gaagaggtcagaggtgccctGatgtctgctttcagtcctga	13	9	3	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:139636073G>A	uc011kqv.1	+	5	584	c.420G>A	c.(418-420)CTG>CTA	p.L140L	TBXAS1_uc003vvh.2_Silent_p.L140L|TBXAS1_uc010lne.2_Silent_p.L72L|TBXAS1_uc011kqu.1_Silent_p.L91L|TBXAS1_uc003vvi.2_Silent_p.L140L|TBXAS1_uc003vvj.2_Silent_p.L140L|TBXAS1_uc011kqw.1_Silent_p.L120L	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	139	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					GAGGTGCCCTGATGTCTGCTT	0.473													0	0	0	0.048971	0	65	134										A	139636073	G	A	139636073	2	1	11	1	0	0	0	0	0	0	0	1	15661	1277	45	1		1	TBXAS1	7	139636073	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	83613424	139636073	19502590	64	2780										
ZNF777	27153	broad.mit.edu	37	chr7	149129112	149129112	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cttgccgcactcggggcaggCgtgcggccgctcgcgcgagt	17	15	0	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr7:149129112C>T	uc003wfv.2	-	6	2414	c.2251G>A	c.(2251-2253)GCC>ACC	p.A751T		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCGGGGCAGGCGTGCGGCCGC	0.682													0	0	0	0.030593	0	28	44										T	149129112	C	T	149129112	3	4	11	1	0	0	0	0	1	0	0	0	18147	768	27	2	248	2	ZNF777	7	149129112	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	9493039	149129112	10009551	65	2781										
CSMD1	64478	broad.mit.edu	37	chr8	3326258	3326258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gtaaacagctttaaacccagGtgagccaatgctatcatccg	8	11	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr8:3326258G>A	uc011kwk.1	-	12	1930	c.1540C>T	c.(1540-1542)CCT>TCT	p.P514S		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	514	CUB 3.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTAAACCCAGGTGAGCCAATG	0.478													0	0	0	0.02938	0	7	9										A	3326258	G	A	3326258	3	1	11	1	0	0	0	0	1	0	0	0	3944	1261	44	2	9206	2	CSMD1	8	3326258	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		3326258	143037764	66	2782										
FAM120A	23196	broad.mit.edu	37	chr9	96320268	96320268	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttgggcctgtcccaccctctCagggcaggggcagaggcttt	14	13	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:96320268C>T	uc004atw.2	+	14	2669	c.2644C>T	c.(2644-2646)CAG>TAG	p.Q882*	FAM120A_uc004aty.2_Nonsense_Mutation_p.Q663*|FAM120A_uc004atz.2_Nonsense_Mutation_p.Q531*|FAM120A_uc010mrg.2_Nonsense_Mutation_p.Q195*	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	882	RNA binding.					cytoplasm|plasma membrane	RNA binding				0						CCCACCCTCTCAGGGCAGGGG	0.602													0	0	0	0.069234	0	10	3										T	96320268	C	T	96320268	4	4	11	1	0	0	0	0	0	1	0	0	5415	827	29	1	2698	1	FAM120A	9	96320268	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		96320268	44893163	67	2783										
KIAA0368	23392	broad.mit.edu	37	chr9	114152334	114152334	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	acaccagatctggctggctaAgatcacttgccagagaacaa	9	11	2	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:114152334A>C	uc004bfe.1	-	31	3743	c.3743T>G	c.(3742-3744)CTT>CGT	p.L1248R		NM_001080398	NP_001073867			KIAA0368 protein												0						TGGCTGGCTAAGATCACTTGC	0.398													0	0	0	0.02938	0	6	6										C	114152334	A	C	114152334	3	2	11	1	0	0	0	0	1	0	0	0	8171	72	3	5	2394	5	KIAA0368	9	114152334	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08	17832066	114152334	27061097	68	2784										
USP20	10868	broad.mit.edu	37	chr9	132614875	132614875	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttgccctcaccttgactccaTaggagaggtgaccaaagagg	11	11	1	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr9:132614875T>G	uc004bys.2	+	3	252	c.41T>G	c.(40-42)ATA>AGA	p.I14R	USP20_uc004byr.2_Missense_Mutation_p.I14R|USP20_uc004byt.1_Missense_Mutation_p.I14R	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	14					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				CTTGACTCCATAGGAGAGGTG	0.577													0	0	0	0.004672	0	2	4										G	132614875	T	G	132614875	3	3	11	1	0	0	0	0	1	0	0	0	17049	1406	49	5	43	5	USP20	9	132614875	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	18462541	132614875	8598556	69	2785										
BMI1	648	broad.mit.edu	37	chr10	22616891	22616891	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cgttatagctgccaatggctCtaatgaagatagaggagagg	13	6	1	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:22616891C>G	uc001irh.2	+	6	968	c.329C>G	c.(328-330)TCT>TGT	p.S110C	BMI1_uc009xkg.2_Missense_Mutation_p.S253C	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	110					hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						GCCAATGGCTCTAATGAAGAT	0.308													0	0	0	0.028581	0	15	63										G	22616891	C	G	22616891	3	3	11	1	0	0	0	0	1	0	0	0	1455	913	32	1	347	1	BMI1	10	22616891	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		22616891	112917856	70	2786										
ARMC3	219681	broad.mit.edu	37	chr10	23321935	23321935	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aaaaaggaatcttctaccatCgagctttgcttttcaaggtg	8	8	3	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:23321935C>T	uc001irm.3	+	18	2475	c.2392C>T	c.(2392-2394)CGA>TGA	p.R798*	ARMC3_uc010qcv.1_Nonsense_Mutation_p.R791*|ARMC3_uc010qcw.1_Nonsense_Mutation_p.R535*	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	798							binding				0						CTTCTACCATCGAGCTTTGCT	0.363													0	0	0	0.076483	0	20	43										T	23321935	C	T	23321935	4	4	11	1	0	0	0	0	0	1	0	0	952	876	31	1	2458	1	ARMC3	10	23321935	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	705044	23321935	112212812	71	2787										
RASGEF1A	221002	broad.mit.edu	37	chr10	43701441	43701441	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cccagagatgaggtgtccatCttggaagatgaggtccccgg	14	10	1	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:43701441C>T	uc001jap.1	-	2	205	c.124G>A	c.(124-126)GAT>AAT	p.D42N	RASGEF1A_uc001jao.1_Missense_Mutation_p.D50N	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	42	N-terminal Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						AGGTGTCCATCTTGGAAGATG	0.647													0	0	0	0.058154	0	10	12										T	43701441	C	T	43701441	3	4	11	1	0	0	0	0	1	0	0	0	13069	913	32	1	1369	1	RASGEF1A	10	43701441	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	20379506	43701441	91833306	72	2788										
ASAH2	56624	broad.mit.edu	37	chr10	51974561	51974561	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	actctcctgtgttgatgcaaCgtggtccaagaatgttgggg	13	8	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:51974561C>T	uc001jjd.2	-	8	1082	c.1082G>A	c.(1081-1083)CGT>CAT	p.R361H	ASAH2_uc009xos.2_Missense_Mutation_p.R361H	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	361	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						GTTGATGCAACGTGGTCCAAG	0.448													0	0	0	0.069288	0	19	28										T	51974561	C	T	51974561	3	4	11	1	0	0	0	0	1	0	0	0	1007	536	19	2	1312	2	ASAH2	10	51974561	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	8273120	51974561	83560186	73	2789										
DDIT4	54541	broad.mit.edu	37	chr10	74034918	74034918	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	caagaagaagctgtacagctCggaacagctgctcattgagg	12	9	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:74034918C>T	uc001jsx.1	+	3	873	c.671C>T	c.(670-672)TCG>TTG	p.S224L		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	224					apoptosis					pancreas(1)	1						CTGTACAGCTCGGAACAGCTG	0.567											OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014758	0	5	10										T	74034918	C	T	74034918	3	4	11	1	0	0	0	0	1	0	0	0	4331	893	31	1	677	1	DDIT4	10	74034918	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	22060357	74034918	61499829	74	2790										
CYP26A1	1592	broad.mit.edu	37	chr10	94836820	94836820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ggaagaatttaatcctgaccGattcatgctgcctcacccag	8	12	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:94836820G>A	uc001kil.2	+	7	1298	c.1253G>A	c.(1252-1254)CGA>CAA	p.R418Q	CYP26A1_uc001kik.1_Missense_Mutation_p.R349Q|CYP26A1_uc001kim.1_Missense_Mutation_p.R316Q	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	418					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				AATCCTGACCGATTCATGCTG	0.448													0	0	0	0.0333	0	17	51										A	94836820	G	A	94836820	3	1	11	1	0	0	0	0	1	0	0	0	4155	1058	37	1	1279	1	CYP26A1	10	94836820	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	20801902	94836820	40697927	75	2791										
CYP2E1	1571	broad.mit.edu	37	chr10	135350733	135350733	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gcaacccgagacaccattttCagaggatacctcatccccaa	6	15	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr10:135350733C>T	uc001lnj.1	+	7	1167	c.1134C>T	c.(1132-1134)TTC>TTT	p.F378F	CYP2E1_uc001lnk.1_Silent_p.F241F|CYP2E1_uc009ybl.1_Silent_p.F179F|CYP2E1_uc009ybm.1_Silent_p.F32F|CYP2E1_uc001lnl.1_Silent_p.F179F	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	378					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	ACACCATTTTCAGAGGATACC	0.542									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				0	0	0	0.055883	0	19	27										T	135350733	C	T	135350733	2	4	11	1	0	0	0	0	0	0	0	1	4170	825	29	1		1	CYP2E1	10	135350733	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	40513913	135350733	184014	76	2792										
SMPD1	6609	broad.mit.edu	37	chr11	6413286	6413286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cacctgtcaatagcttccctCcccccttcattgagggcaac	6	17	2	1	rs142476839		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:6413286C>T	uc001mcw.2	+	2	1165	c.991C>T	c.(991-993)CCC>TCC	p.P331S	SMPD1_uc001mcv.1_Intron|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.P331S|SMPD1_uc009yew.2_Missense_Mutation_p.P330S	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	329					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	TAGCTTCCCTCCCCCCTTCAT	0.612													0	0	0	0.024245	0	13	25										T	6413286	C	T	6413286	3	4	11	1	0	0	0	0	1	0	0	0	14804	855	30	1	997	1	SMPD1	11	6413286	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		6413286	128593230	77	2793										
OR10A6	390093	broad.mit.edu	37	chr11	7949563	7949563	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	acagaactcgaatgtaagacAagagtatcaacaagaaagga	9	6	1	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:7949563A>G	uc010rbh.1	-	1	647	c.647T>C	c.(646-648)TTG>TCG	p.L216S		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AATGTAAGACAAGAGTATCAA	0.438													0	0	0	0.043863	0	18	43										G	7949563	A	G	7949563	3	3	11	1	0	0	0	0	1	0	0	0	10894	131	5	5	300	5	OR10A6	11	7949563	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08	1536277	7949563	127056953	78	2794										
BEST1	7439	broad.mit.edu	37	chr11	61727388	61727388	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ccctgttggctgtggatgagAtgcaccaggacctgcctcgg	14	12	0	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:61727388A>G	uc001nss.2	+	9	1553	c.973A>G	c.(973-975)ATG>GTG	p.M325V	BEST1_uc010rlq.1_Silent_p.R332R|BEST1_uc010rlr.1_Intron|BEST1_uc010rls.1_Intron|BEST1_uc001nsr.2_Missense_Mutation_p.M265V|BEST1_uc009ynt.2_RNA|BEST1_uc010rlt.1_Missense_Mutation_p.M265V|BEST1_uc001nst.2_Missense_Mutation_p.M238V|BEST1_uc010rlu.1_Silent_p.R286R|BEST1_uc010rlv.1_Missense_Mutation_p.M219V	NM_004183	NP_004174	O76090	BEST1_HUMAN	bestrophin 1 isoform 1	325	Cytoplasmic (Potential).		M -> T (in ARB).		response to stimulus|transepithelial chloride transport|visual perception	basolateral plasma membrane|chloride channel complex|cytosol|membrane fraction	chloride channel activity			central_nervous_system(1)	1						TGTGGATGAGATGCACCAGGA	0.572													0	0	0	0.004672	0	2	7										G	61727388	A	G	61727388	3	3	11	1	0	0	0	0	1	0	0	0	1404	333	12	5	1003	5	BEST1	11	61727388	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08	53777825	61727388	73279128	79	2795										
CCDC87	55231	broad.mit.edu	37	chr11	66359214	66359214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aatggtcactggctgtgggtGaagtggaaaggatttggggg	19	3	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:66359214G>A	uc001oiq.3	-	1	1341	c.1273C>T	c.(1273-1275)CAC>TAC	p.H425Y	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	425										ovary(1)|skin(1)	2						GGCTGTGGGTGAAGTGGAAAG	0.552													0	0	0	0.038395	0	18	39										A	66359214	G	A	66359214	3	1	11	1	0	0	0	0	1	0	0	0	2862	1290	45	1	1280	1	CCDC87	11	66359214	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	4631826	66359214	68647302	80	2796										
KIAA1826	84437	broad.mit.edu	37	chr11	105880796	105880796	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttttctctcctggaatctggTatgacggatgacaacatttc	8	9	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:105880796T>C	uc001piy.2	-	3	677	c.504A>G	c.(502-504)ATA>ATG	p.I168M	KIAA1826_uc001piz.2_Missense_Mutation_p.I168M	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	168						nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		TGGAATCTGGTATGACGGATG	0.393													0	0	0	0.064281	0	35	57										C	105880796	T	C	105880796	3	2	11	1	0	0	0	0	1	0	0	0	8260	1628	57	5	537	5	KIAA1826	11	105880796	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	39521582	105880796	29125720	81	2797										
MLL	4297	broad.mit.edu	37	chr11	118374132	118374132	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aagctccacccatgcaagtaGaaggatctgccaaggaatta	9	10	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:118374132G>A	uc001pta.2	+	27	7539	c.7516G>A	c.(7516-7518)GAA>AAA	p.E2506K	MLL_uc001ptb.2_Missense_Mutation_p.E2509K	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2506					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CATGCAAGTAGAAGGATCTGC	0.448			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.105934	0	13	31										A	118374132	G	A	118374132	3	1	11	1	0	0	0	0	1	0	0	0	9620	943	33	1	7622	1	MLL	11	118374132	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	12493336	118374132	16632384	82	2798			2	10		3	3	1000	G		7.722126e-06
MLL	4297	broad.mit.edu	37	chr11	118374590	118374590	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	actgggaagaagcgaggcaaGagatcagctgaaggacaggt	16	6	1	3	rs142807735	byFrequency	TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:118374590G>C	uc001pta.2	+	27	7997	c.7974G>C	c.(7972-7974)AAG>AAC	p.K2658N	MLL_uc001ptb.2_Missense_Mutation_p.K2661N	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2658					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AGCGAGGCAAGAGATCAGCTG	0.443			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.069234	0	9	31										C	118374590	G	C	118374590	3	2	11	1	0	0	0	0	1	0	0	0	9620	933	33	1	8080	1	MLL	11	118374590	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	458	118374590	16631926	83	2799			2	10		3	3	1000	G		7.722126e-06
MLL	4297	broad.mit.edu	37	chr11	118375131	118375131	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	attcagacaataacaacagtGatgactgtgggaatatcctg	9	7	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr11:118375131G>A	uc001pta.2	+	27	8538	c.8515G>A	c.(8515-8517)GAT>AAT	p.D2839N	MLL_uc001ptb.2_Missense_Mutation_p.D2842N	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2839					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TAACAACAGTGATGACTGTGG	0.448			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.069456	0	37	93										A	118375131	G	A	118375131	3	1	11	1	0	0	0	0	1	0	0	0	9620	1290	45	1	8621	1	MLL	11	118375131	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	541	118375131	16631385	84	2800			2	10		3	3	1000	G		7.722126e-06
PUS7L	83448	broad.mit.edu	37	chr12	44124323	44124323	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	atgtcatgatcttccattagTtggtatgagagattacaggg	11	5	2	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr12:44124323T>C	uc001rnq.3	-	9	2451	c.1962A>G	c.(1960-1962)CAA>CAG	p.Q654Q	PUS7L_uc001rnr.3_Silent_p.Q654Q|PUS7L_uc001rns.3_Silent_p.Q654Q|PUS7L_uc009zkb.2_Silent_p.Q341Q	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	654					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		CTTCCATTAGTTGGTATGAGA	0.368													0	0	0	0.074837	0	34	92										C	44124323	T	C	44124323	2	2	11	1	0	0	0	0	0	0	0	1	12834	1722	60	5		5	PUS7L	12	44124323	Silent	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08		44124323	89727572	85	2801										
SLC4A8	9498	broad.mit.edu	37	chr12	51868160	51868160	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tgccagagaatccaaacaatCacaccctccagtactggaag	7	13	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr12:51868160C>T	uc001rys.1	+	15	2117	c.1939C>T	c.(1939-1941)CAC>TAC	p.H647Y	SLC4A8_uc010sni.1_Missense_Mutation_p.H594Y|SLC4A8_uc001rym.2_Missense_Mutation_p.H594Y|SLC4A8_uc001ryn.2_Missense_Mutation_p.H594Y|SLC4A8_uc001ryo.2_Missense_Mutation_p.H594Y|SLC4A8_uc010snj.1_Missense_Mutation_p.H674Y|SLC4A8_uc001ryq.3_Missense_Mutation_p.H647Y|SLC4A8_uc001ryr.2_Missense_Mutation_p.H647Y|SLC4A8_uc010snk.1_Missense_Mutation_p.H594Y	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	647	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TCCAAACAATCACACCCTCCA	0.458													0	0	0	0.047766	0	9	30										T	51868160	C	T	51868160	3	4	11	1	0	0	0	0	1	0	0	0	14659	826	29	1	1997	1	SLC4A8	12	51868160	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	7743837	51868160	81983735	86	2802										
MYCBP2	23077	broad.mit.edu	37	chr13	77743819	77743819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gcagcatggaaaacagactgGaagaactcagcagttctgga	12	8	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr13:77743819G>A	uc001vkf.2	-	40	5802	c.5711C>T	c.(5710-5712)TCC>TTC	p.S1904F	MYCBP2_uc010aev.2_Missense_Mutation_p.S1308F	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1904					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AAACAGACTGGAAGAACTCAG	0.383													0	0	0	0.043863	0	18	66										A	77743819	G	A	77743819	3	1	11	1	0	0	0	0	1	0	0	0	10018	1174	41	1	8391	1	MYCBP2	13	77743819	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		77743819	37426059	87	2803										
RTN1	6252	broad.mit.edu	37	chr14	60212834	60212834	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttcttggtgcttcacctcctCgggtctggttatgtcaatgt	10	10	4	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr14:60212834C>T	uc001xen.1	-	2	816	c.607G>A	c.(607-609)GAG>AAG	p.E203K		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	203					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		TTCACCTCCTCGGGTCTGGTT	0.453													0	0	0	0.048971	0	70	138										T	60212834	C	T	60212834	3	4	11	1	0	0	0	0	1	0	0	0	13725	893	31	1	1820	1	RTN1	14	60212834	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		60212834	47136706	88	2804										
SNX22	79856	broad.mit.edu	37	chr15	64446590	64446590	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	taattctatcccacagagtcGctgcccaacgtggtggtgaa	10	11	1	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr15:64446590G>C	uc002anc.1	+	7	524	c.465G>C	c.(463-465)TCG>TCC	p.S155S	SNX22_uc002amz.1_3'UTR|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	155					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						CCACAGAGTCGCTGCCCAACG	0.602											OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.049695	0	19	111										C	64446590	G	C	64446590	2	2	11	1	0	0	0	0	0	0	0	1	14894	1074	38	4		4	SNX22	15	64446590	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		64446590	38084802	89	2805										
SNX33	257364	broad.mit.edu	37	chr15	75941596	75941596	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cgtggggagacagggctcttTcctgcctcttatgtggagat	14	9	2	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr15:75941596T>G	uc002bau.2	+	1	249	c.153T>G	c.(151-153)TTT>TTG	p.F51L	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_5'Flank	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	51	SH3.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						CAGGGCTCTTTCCTGCCTCTT	0.587													0	0	0	0.076483	0	23	61										G	75941596	T	G	75941596	3	3	11	1	0	0	0	0	1	0	0	0	14903	1780	62	5	155	5	SNX33	15	75941596	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	11495006	75941596	26589796	90	2806										
IFT140	9742	broad.mit.edu	37	chr16	1616196	1616196	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ctcattaaaggacagcgtctCtctccgatcaatttgtccag	7	12	4	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:1616196C>G	uc002cmb.2	-	16	2229	c.1867G>C	c.(1867-1869)GAG>CAG	p.E623Q	IFT140_uc002clz.2_Missense_Mutation_p.E274Q	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	623										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GACAGCGTCTCTCTCCGATCA	0.428													0	0	0	0.048971	0	57	135										G	1616196	C	G	1616196	3	3	11	1	0	0	0	0	1	0	0	0	7556	922	32	1	2585	1	IFT140	16	1616196	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		1616196	88738557	91	2807										
C16orf59	80178	broad.mit.edu	37	chr16	2510687	2510687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gaaactaatggagaggacccCcttccaggtaaacctccacc	8	14	0	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:2510687C>T	uc002cqh.2	+	3	220	c.189C>T	c.(187-189)CCC>CCT	p.P63P	C16orf59_uc002cqf.1_Silent_p.P63P|C16orf59_uc002cqg.1_5'UTR|C16orf59_uc002cqi.2_5'UTR|C16orf59_uc010uwb.1_5'Flank	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	hypothetical protein LOC80178	63											0		Ovarian(90;0.17)				GAGAGGACCCCCTTCCAGGTA	0.637													0	0	0	0.09319	0	12	16										T	2510687	C	T	2510687	2	4	11	1	0	0	0	0	0	0	0	1	1823	610	22	2		2	C16orf59	16	2510687	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	894491	2510687	87844066	92	2808										
CPPED1	55313	broad.mit.edu	37	chr16	12758794	12758794	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tcttctattcctttctcactCagctcatctagactgtagta	4	12	6	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:12758794C>G	uc002dca.3	-	4	1005	c.894G>C	c.(892-894)CTG>CTC	p.L298L	CPPED1_uc002dcb.3_Silent_p.L156L|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	298							hydrolase activity|metal ion binding				0						CTTTCTCACTCAGCTCATCTA	0.478													0	0	0	0.034045	0	26	43										G	12758794	C	G	12758794	2	3	11	1	0	0	0	0	0	0	0	1	3822	813	29	1		1	CPPED1	16	12758794	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	10248107	12758794	77595959	93	2809										
C16orf88	400506	broad.mit.edu	37	chr16	19726111	19726111	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aggcagcgtggtctcaggttCtacatgctcctcgcaaaggg	13	11	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:19726111C>G	uc002dgq.2	-	2	262	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	IQCK_uc002dgr.2_5'Flank|IQCK_uc002dgs.2_5'Flank|IQCK_uc010vat.1_5'Flank|IQCK_uc010bwc.2_5'Flank|IQCK_uc010vau.1_5'Flank	NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	83	Lys-rich.					nucleolus					0						GTCTCAGGTTCTACATGCTCC	0.488													0	0	0	0.038395	0	16	37										G	19726111	C	G	19726111	3	3	11	1	0	0	0	0	1	0	0	0	1841	922	32	1	1145	1	C16orf88	16	19726111	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	6967317	19726111	70628642	94	2810										
CHD9	80205	broad.mit.edu	37	chr16	53272307	53272307	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttggcaaaactattcaatcaAttacattcctctatgaaatc	3	9	3	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:53272307A>G	uc002ehb.2	+	11	2850	c.2686A>G	c.(2686-2688)ATT>GTT	p.I896V	CHD9_uc002egy.2_Missense_Mutation_p.I896V|CHD9_uc002eha.1_Missense_Mutation_p.I896V|CHD9_uc002ehc.2_Missense_Mutation_p.I896V|CHD9_uc002ehf.2_Missense_Mutation_p.I10V|CHD9_uc002ehd.2_Missense_Mutation_p.I422V|CHD9_uc002ehe.1_Missense_Mutation_p.I10V	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	896	Helicase ATP-binding.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TATTCAATCAATTACATTCCT	0.358													0	0	0	0.049695	0	18	32										G	53272307	A	G	53272307	3	3	11	1	0	0	0	0	1	0	0	0	3332	101	4	5	2728	5	CHD9	16	53272307	Missense_Mutation	SNP	A	TCGA-BT-A20Q-01A-11D-A14W-08	33546196	53272307	37082446	95	2811										
IL34	146433	broad.mit.edu	37	chr16	70693984	70693984	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agagccctcattgcagtatgCggccacccagctgtaccctc	9	16	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:70693984C>T	uc002ezh.1	+	6	1006	c.623C>T	c.(622-624)GCG>GTG	p.A208V	IL34_uc002ezi.1_Missense_Mutation_p.A207V	NM_152456	NP_689669	Q6ZMJ4	IL34_HUMAN	interleukin 34 precursor	208					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2						TTGCAGTATGCGGCCACCCAG	0.647													0	0	0	0.009096	0	4	123										T	70693984	C	T	70693984	3	4	11	1	0	0	0	0	1	0	0	0	7694	768	27	2	645	2	IL34	16	70693984	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	17421677	70693984	19660769	96	2812										
HPR	3250	broad.mit.edu	37	chr16	72110371	72110371	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ctgaccacggctaaaaatctCttcctgaaccattcagaaaa	5	12	2	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr16:72110371C>G	uc002fby.2	+	5	468	c.438C>G	c.(436-438)CTC>CTG	p.L146L	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	146	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				CTAAAAATCTCTTCCTGAACC	0.478													0	0	0	0.09319	0	13	24										G	72110371	C	G	72110371	2	3	11	1	0	0	0	0	0	0	0	1	7337	900	32	1		1	HPR	16	72110371	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	1416387	72110371	18244382	97	2813										
C17orf81	23587	broad.mit.edu	37	chr17	7162148	7162148	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	atcctttgtacctacaggtgGatcccacaactcatttgacc	6	13	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:7162148G>A	uc002gfg.1	+	8	846	c.739G>A	c.(739-741)GAT>AAT	p.D247N	C17orf81_uc002gfj.2_3'UTR|C17orf81_uc010cmb.2_3'UTR|C17orf81_uc002gfh.1_Missense_Mutation_p.D247N|C17orf81_uc002gfi.1_Missense_Mutation_p.D247N|C17orf81_uc002gfl.1_Intron	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						CCTACAGGTGGATCCCACAAC	0.502													0	0	0	0.0333	0	18	20										A	7162148	G	A	7162148	3	1	11	1	0	0	0	0	1	0	0	0	1886	1174	41	1	870	1	C17orf81	17	7162148	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		7162148	74033062	98	2814										
C17orf81	23587	broad.mit.edu	37	chr17	7162193	7162193	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	accttcacctgtccaagaaaGagagagaagccagagatagc	10	10	1	4			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:7162193G>C	uc002gfg.1	+	8	891	c.784G>C	c.(784-786)GAG>CAG	p.E262Q	C17orf81_uc002gfj.2_3'UTR|C17orf81_uc010cmb.2_3'UTR|C17orf81_uc002gfh.1_Missense_Mutation_p.E262Q|C17orf81_uc002gfi.1_Missense_Mutation_p.E262Q|C17orf81_uc002gfl.1_Intron	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						GTCCAAGAAAGAGAGAGAAGC	0.512													0	0	0	0.028581	0	17	21										C	7162193	G	C	7162193	3	2	11	1	0	0	0	0	1	0	0	0	1886	943	33	1	915	1	C17orf81	17	7162193	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	45	7162193	74033017	99	2815										
NCOR1	9611	broad.mit.edu	37	chr17	16022773	16022773	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	catttcttcttctgtccatcGagaggtctccacaggctctg	8	13	5	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:16022773G>A	uc002gpo.2	-	17	2119	c.1879C>T	c.(1879-1881)CGA>TGA	p.R627*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.R627*|NCOR1_uc002gpp.1_Nonsense_Mutation_p.R518*|NCOR1_uc002gpr.2_Nonsense_Mutation_p.R518*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	627	SANT 2.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TCTGTCCATCGAGAGGTCTCC	0.333													0	0	0	0.086207	0	31	38										A	16022773	G	A	16022773	4	1	11	1	0	0	0	0	0	1	0	0	10235	1066	37	1	5563	1	NCOR1	17	16022773	Nonsense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	8860580	16022773	65172437	100	2816										
EPN2	22905	broad.mit.edu	37	chr17	19216560	19216560	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ctggggcgggccagcggctcCtgcgagtacttcagacccct	14	15	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:19216560C>A	uc002gvd.3	+	7	1563	c.1115C>A	c.(1114-1116)CCT>CAT	p.P372H	EPN2_uc010cql.1_Missense_Mutation_p.P81H|EPN2_uc002gve.3_Missense_Mutation_p.P315H|EPN2_uc002gvf.3_Missense_Mutation_p.P87H|EPN2_uc010vyo.1_Missense_Mutation_p.P80H|EPN2_uc002gvg.1_Missense_Mutation_p.P315H|EPN2_uc010vyp.1_Missense_Mutation_p.P308H|EPN2_uc010vyq.1_Missense_Mutation_p.P309H|EPN2_uc002gvh.1_Missense_Mutation_p.P372H|EPN2_uc002gvj.3_Missense_Mutation_p.P35H	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	372	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CCAGCGGCTCCTGCGAGTACT	0.657													1	0	2.0701e-58	0.048971	2.21903e-58	141	277										A	19216560	C	A	19216560	3	1	11	1	0	0	0	0	1	0	0	0	5186	681	24	4	1133	4	EPN2	17	19216560	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	3193787	19216560	61978650	101	2817										
RNF112	7732	broad.mit.edu	37	chr17	19319463	19319463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gaggcttctggaaggggaccGagagccccttctccaggaag	15	11	2	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:19319463G>A	uc010vyw.1	+	14	2070	c.1871G>A	c.(1870-1872)CGA>CAA	p.R624Q	RNF112_uc010vyv.1_Missense_Mutation_p.R625Q	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	624							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						GAAGGGGACCGAGAGCCCCTT	0.627													0	0	0	0.069234	0	10	25										A	19319463	G	A	19319463	3	1	11	1	0	0	0	0	1	0	0	0	13426	1058	37	1	1635	1	RNF112	17	19319463	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	102903	19319463	61875747	102	2818										
DHRS7B	25979	broad.mit.edu	37	chr17	21094331	21094333	+	In_Frame_Del	DEL	GAA	GAA	-													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gatgttcttgctgctgtgggGaagaagaagaaagatgtgat							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:21094331_21094333delGAA	uc002gyo.2	+	7	870_872	c.843_845delGAA	c.(841-846)GGGAAG>GGG	p.K285del		NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	285	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			pancreas(1)	1						CTGCTGTGGGGAAGAAGAAGAAA	0.507																		11	1646	---	---								-	21094333	GAA	-	21094331	7	5	11	1	0	1	0	1	0	0	0	0	4496	1161	41	0	869	0	DHRS7B	17	21094331	In_Frame_Del	DEL	GAA	TCGA-BT-A20Q-01A-11D-A14W-08	1774868	21094331	60100879	103	2819										
UBTF	7343	broad.mit.edu	37	chr17	42289089	42289089	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ccttcatgttggccatgagcTctgcgcagtacagcgagtag	12	11	2	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:42289089T>G	uc002igb.2	-	9	999	c.932A>C	c.(931-933)GAG>GCG	p.E311A	UBTF_uc002igc.2_Missense_Mutation_p.E274A|UBTF_uc010czs.2_Missense_Mutation_p.E311A|UBTF_uc002igd.2_Missense_Mutation_p.E274A|UBTF_uc010czt.2_Missense_Mutation_p.E311A|UBTF_uc002ige.2_Missense_Mutation_p.E274A	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	311	HMG box 3.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGCCATGAGCTCTGCGCAGTA	0.617													0	0	0	0.080935	0	12	51										G	42289089	T	G	42289089	3	3	11	1	0	0	0	0	1	0	0	0	16906	1551	54	5	1410	5	UBTF	17	42289089	Missense_Mutation	SNP	T	TCGA-BT-A20Q-01A-11D-A14W-08	21194758	42289089	38906121	104	2820										
KIAA1267	284058	broad.mit.edu	37	chr17	44109507	44109507	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ccacaggggtgaggggtgctGagtgcagttccgggctaatg	18	8	0	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:44109507G>C	uc002ikb.2	-	13	3081	c.2996C>G	c.(2995-2997)TCA>TGA	p.S999*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.S999*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.S999*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.S998*|KIAA1267_uc010wkb.1_Nonsense_Mutation_p.S330*|KIAA1267_uc010wkc.1_Nonsense_Mutation_p.S267*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	999						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				GAGGGGTGCTGAGTGCAGTTC	0.602													0	0	0	0.069234	0	11	55										C	44109507	G	C	44109507	4	2	11	1	0	0	0	0	0	1	0	0	8219	1294	45	1	329	1	KIAA1267	17	44109507	Nonsense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	1820418	44109507	37085703	105	2821										
COL1A1	1277	broad.mit.edu	37	chr17	48275121	48275121	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	cattctttccagggggacctGggggacctcggggacccatg	15	12	1	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:48275121G>C	uc002iqm.2	-	9	794	c.668C>G	c.(667-669)CCA>CGA	p.P223R		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	223	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	AGGGGGACCTGGGGGACCTCG	0.507			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						0	0	0	0.086207	0	36	126										C	48275121	G	C	48275121	3	2	11	1	0	0	0	0	1	0	0	0	3677	1348	47	4	3898	4	COL1A1	17	48275121	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	4165614	48275121	32920089	106	2822										
CASKIN2	57513	broad.mit.edu	37	chr17	73498817	73498819	+	In_Frame_Del	DEL	AGG	AGG	-													0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ggcagggggcccggccaagtAggagaaggcccagggtgcgc							TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:73498817_73498819delAGG	uc002joc.2	-	18	2886_2888	c.2336_2338delCCT	c.(2335-2340)TCCTAC>TAC	p.S779del	CASKIN2_uc010wsc.1_In_Frame_Del_p.S697del	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	779	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCGGCCAAGTAGGAGAAGGCCCA	0.695																		5	9	---	---								-	73498819	AGG	-	73498817	7	5	11	1	0	1	0	1	0	0	0	0	2667	420	15	0	1282	0	CASKIN2	17	73498817	In_Frame_Del	DEL	AGG	TCGA-BT-A20Q-01A-11D-A14W-08	25223696	73498817	7696393	107	2823										
PDE6G	5148	broad.mit.edu	37	chr17	79620333	79620333	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gccttgggcggttccaggttCatggtgaggctgacggagac	17	9	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr17:79620333C>T	uc002kay.3	-	2	147	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PDE6G_uc002kaz.3_Intron	NM_002602	NP_002593	P18545	CNRG_HUMAN	phosphodiesterase 6G	1					platelet activation|visual perception	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity				0	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GTTCCAGGTTCATGGTGAGGC	0.662													0	0	0	0.0918	0	26	32										T	79620333	C	T	79620333	3	4	11	1	0	0	0	0	1	0	0	0	11649	826	29	1	272	1	PDE6G	17	79620333	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	6121516	79620333	1574877	108	2824										
POLI	11201	broad.mit.edu	37	chr18	51818253	51818253	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	atatacttatgaaactttttCgaaatatggtgaatgtgaag	8	3	0	3	rs56152401		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr18:51818253C>T	uc002lfj.3	+	9	1317	c.1249C>T	c.(1249-1251)CGA>TGA	p.R417*	POLI_uc010xds.1_Nonsense_Mutation_p.R338*|POLI_uc002lfk.3_Nonsense_Mutation_p.R314*|POLI_uc010dpg.2_Nonsense_Mutation_p.R13*	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	417					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		GAAACTTTTTCGAAATATGGT	0.308								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.069234	0	10	41										T	51818253	C	T	51818253	4	4	11	1	0	0	0	0	0	1	0	0	12203	876	31	1	1283	1	POLI	18	51818253	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		51818253	26258995	109	2825										
ZNF516	9658	broad.mit.edu	37	chr18	74091604	74091604	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ggctggcattctttgccaccGagggcaggcggggggcccgt	18	12	1	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr18:74091604G>A	uc010dqx.1	-	3	2701	c.2466C>T	c.(2464-2466)CTC>CTT	p.L822L	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	822					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTTTGCCACCGAGGGCAGGCG	0.622													0	0	0	0.041601	0	31	72										A	74091604	G	A	74091604	2	1	11	1	0	0	0	0	0	0	0	1	17957	1045	37	1		1	ZNF516	18	74091604	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	22273351	74091604	3985644	110	2826										
ELAVL1	1994	broad.mit.edu	37	chr19	8046039	8046039	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctgcatccttcgcggtcacGtagttcacaaagccatagcc	8	14	3	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:8046039G>A	uc002mjb.2	-	3	371	c.204C>T	c.(202-204)TAC>TAT	p.Y68Y		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	68	RRM 1.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						TCGCGGTCACGTAGTTCACAA	0.532													0	0	0	0.020292	0	14	46										A	8046039	G	A	8046039	2	1	11	1	0	0	0	0	0	0	0	1	5049	1140	40	2		2	ELAVL1	19	8046039	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		8046039	51082944	111	2827										
LPAR2	9170	broad.mit.edu	37	chr19	19737749	19737749	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agtgtggccaccgacgcagtGaggcttgtgtccagcaagcc	14	12	0	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:19737749G>A	uc002nnb.3	-	2	484	c.345C>T	c.(343-345)CTC>CTT	p.L115L	LPAR2_uc002nna.3_Silent_p.L115L|LPAR2_uc002nnc.3_Silent_p.L115L	NM_004720	NP_004711	Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	115	Helical; Name=3; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding			ovary(1)|breast(1)	2						CCGACGCAGTGAGGCTTGTGT	0.672													0	0	0	0.021553	0	6	6										A	19737749	G	A	19737749	2	1	11	1	0	0	0	0	0	0	0	1	8905	1277	45	1		1	LPAR2	19	19737749	Silent	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	11691710	19737749	39391234	112	2828										
ZNF573	126231	broad.mit.edu	37	chr19	38229523	38229523	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	tctcatgttgaacaaggtttGaagcacgactgaaggccttc	10	9	1	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:38229523G>C	uc002ohe.2	-	4	1890	c.1868C>G	c.(1867-1869)TCA>TGA	p.S623*	ZNF573_uc010efs.2_Nonsense_Mutation_p.S536*|ZNF573_uc002ohd.2_Nonsense_Mutation_p.S621*|ZNF573_uc002ohf.2_Nonsense_Mutation_p.S565*|ZNF573_uc002ohg.2_Nonsense_Mutation_p.S535*	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	603	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			AACAAGGTTTGAAGCACGACT	0.413													0	0	0	0.042209	0	46	77										C	38229523	G	C	38229523	4	2	11	1	0	0	0	0	0	1	0	0	18002	1294	45	1	133	1	ZNF573	19	38229523	Nonsense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	18491774	38229523	20899460	113	2829										
TRPM4	54795	broad.mit.edu	37	chr19	49713574	49713574	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gcgctggccccgccctttatCgtcatctcccacttgcgcct	8	19	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:49713574C>T	uc002pmw.2	+	21	3312	c.3240C>T	c.(3238-3240)ATC>ATT	p.I1080I	TRPM4_uc010emu.2_Silent_p.I935I|TRPM4_uc010yak.1_Silent_p.I544I|TRPM4_uc002pmx.2_Silent_p.I906I|TRPM4_uc010emv.2_Silent_p.I965I|TRPM4_uc010yal.1_Silent_p.I726I|TRPM4_uc002pmy.2_Silent_p.I422I	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	1080	Cytoplasmic (Potential).|Calmodulin-binding.				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CGCCCTTTATCGTCATCTCCC	0.637													0	0	0	0.062417	0	20	30										T	49713574	C	T	49713574	2	4	11	1	0	0	0	0	0	0	0	1	16585	874	31	1		1	TRPM4	19	49713574	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	11484051	49713574	9415409	114	2830										
KIR3DL1	3811	broad.mit.edu	37	chr19	55329821	55329821	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	gcccagcgctgtggtgcctcGaggaggacacgtgactcttc	14	13	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:55329821G>A	uc002qhk.3	+	3	185	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_5'UTR|KIR3DL1_uc010esf.2_Intron|KIR3DL1_uc010yfo.1_5'UTR|KIR3DL1_uc002qhl.3_Missense_Mutation_p.R41Q	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	41	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GTGGTGCCTCGAGGAGGACAC	0.542													0	0	0	0.09836	0	37	54										A	55329821	G	A	55329821	3	1	11	1	0	0	0	0	1	0	0	0	8320	1058	37	1	132	1	KIR3DL1	19	55329821	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	5616247	55329821	3799162	115	2831										
NLRP8	126205	broad.mit.edu	37	chr19	56466176	56466176	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttgccaagaggtgaaccagaCgacagaccagagcttctccg	11	12	1	5			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr19:56466176C>T	uc002qmh.2	+	3	823	c.752C>T	c.(751-753)ACG>ATG	p.T251M	NLRP8_uc010etg.2_Missense_Mutation_p.T251M	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	251	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GTGAACCAGACGACAGACCAG	0.512													0	0	0	0.080422	0	38	75										T	56466176	C	T	56466176	3	4	11	1	0	0	0	0	1	0	0	0	10483	536	19	2	762	2	NLRP8	19	56466176	Missense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	1136355	56466176	2662807	116	2832										
SNRPB2	6629	broad.mit.edu	37	chr20	16719531	16719531	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agctaatacccaaggaaattCaacaccaaatcctcaggtaa	5	11	2	0			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:16719531C>G	uc002wph.1	+	5	629	c.413C>G	c.(412-414)TCA>TGA	p.S138*	SNRPB2_uc002wpi.1_Nonsense_Mutation_p.S138*	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	138						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						CAAGGAAATTCAACACCAAAT	0.338													0	0	0	0.069234	0	8	22										G	16719531	C	G	16719531	4	3	11	1	0	0	0	0	0	1	0	0	14862	838	29	1	427	1	SNRPB2	20	16719531	Nonsense_Mutation	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		16719531	46305989	117	2833										
CEP250	11190	broad.mit.edu	37	chr20	34051427	34051427	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agtaccgaagctggtgccaaGagctggagaagcggctagaa	15	8	0	3			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr20:34051427G>C	uc002xcm.2	+	6	885	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	72					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTGGTGCCAAGAGCTGGAGAA	0.547											OREG0025891	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.021553	0	5	25										C	34051427	G	C	34051427	3	2	11	1	0	0	0	0	1	0	0	0	3252	943	33	1	220	1	CEP250	20	34051427	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	17331896	34051427	28974093	118	2834										
BRWD1	54014	broad.mit.edu	37	chr21	40604198	40604198	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ataagcttcatgaccctgtcGaaaatatattacctacaaaa	4	9	1	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr21:40604198G>A	uc002yxk.1	-	25	3044	c.2905C>T	c.(2905-2907)CGA>TGA	p.R969*	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Nonsense_Mutation_p.R969*|BRWD1_uc010god.1_5'Flank	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	969					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TGACCCTGTCGAAAATATATT	0.308													0	0	0	0.02938	0	6	33										A	40604198	G	A	40604198	4	1	11	1	0	0	0	0	0	1	0	0	1525	1066	37	1	4368	1	BRWD1	21	40604198	Nonsense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		40604198	7525697	119	2835										
GNAZ	2781	broad.mit.edu	37	chr22	23465561	23465561	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	agtaacatccagtttgtcttCgacgcggtgacagacgtcat	10	10	2	2	rs139659965		TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chr22:23465561C>T	uc002zwu.1	+	3	1548	c.1011C>T	c.(1009-1011)TTC>TTT	p.F337F	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	337						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		AGTTTGTCTTCGACGCGGTGA	0.562													0	0	0	0.024245	0	13	16										T	23465561	C	T	23465561	2	4	11	1	0	0	0	0	0	0	0	1	6514	883	31	1		1	GNAZ	22	23465561	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08		23465561	27839005	120	2836										
IL2RG	3561	broad.mit.edu	37	chrX	70331308	70331308	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	ttcattcccattgggcgtcaGaattgtcgtgttcagcccca	9	12	3	1			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chrX:70331308G>C	uc004dyw.1	-	1	96	c.82C>G	c.(82-84)CTG>GTG	p.L28V	IL2RG_uc004dyv.1_5'Flank|IL2RG_uc004dyx.1_5'UTR	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	28	Extracellular (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	TTGGGCGTCAGAATTGTCGTG	0.562									Severe_Combined_Immunodeficiency_X-linked				0	0	0	0.09319	0	12	9										C	70331308	G	C	70331308	3	2	11	1	0	0	0	0	1	0	0	0	7688	933	33	1	1059	1	IL2RG	23	70331308	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08		70331308	84939252	121	2837										
WBP5	51186	broad.mit.edu	37	chrX	102612724	102612724	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aggaggagaagctagaggagGaggccaaagcaaaaggaact	16	5	0	2			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chrX:102612724G>A	uc004ekd.2	+	3	413	c.112G>A	c.(112-114)GAG>AAG	p.E38K	WBP5_uc004eke.2_Missense_Mutation_p.E38K|WBP5_uc004ekf.2_Missense_Mutation_p.E38K|WBP5_uc004ekg.2_Missense_Mutation_p.E38K	NM_001006612	NP_001006613	Q9UHQ7	WPB5_HUMAN	WW domain binding protein 5	38	Glu-rich.										0						GCTAGAGGAGGAGGCCAAAGC	0.408													0	0	0	0.055883	0	21	13										A	102612724	G	A	102612724	3	1	11	1	0	0	0	0	1	0	0	0	17259	1175	41	1	114	1	WBP5	23	102612724	Missense_Mutation	SNP	G	TCGA-BT-A20Q-01A-11D-A14W-08	32281416	102612724	52657836	122	2838										
SRPK3	26576	broad.mit.edu	37	chrX	153049816	153049816	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.409836065573771	50	2.69969638978088e-16	3.43188405797101	5.49987096774194	2.38093989071038	0.559645380711773	0.7111952018206	35	aatgcagataagatcaagatCaagatcgcagacctgggcaa	10	8	2	5			TCGA-BT-A20Q-01A-11D-A14W-08	TCGA-BT-A20Q-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c619cbc-9e91-4716-9711-5236e55d8f46	21d0907a-ac47-4a72-8f6c-74d25949fe11	g.chrX:153049816C>T	uc004fil.2	+	11	1247	c.1215C>T	c.(1213-1215)ATC>ATT	p.I405I	SRPK3_uc004fik.2_Silent_p.I471I|SRPK3_uc010nul.2_Silent_p.I329I|SRPK3_uc004fin.2_Silent_p.I404I|SRPK3_uc004fim.2_Silent_p.I371I	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	405	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGATCAAGATCAAGATCGCAG	0.607													0	0	0	0.038147	0	8	6										T	153049816	C	T	153049816	2	4	11	1	0	0	0	0	0	0	0	1	15160	816	29	1		1	SRPK3	23	153049816	Silent	SNP	C	TCGA-BT-A20Q-01A-11D-A14W-08	50437092	153049816	2220744	123	2839										
UBE4B	10277	broad.mit.edu	37	chr1	10186932	10186932	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gactactttaaataccccctCatggtaaaactttgttcttt	4	10	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:10186932C>G	uc001aqs.3	+	11	2348	c.1635C>G	c.(1633-1635)CTC>CTG	p.L545L	UBE4B_uc001aqr.3_Silent_p.L416L|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_5'UTR	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	545					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AATACCCCCTCATGGTAAAAC	0.343													0	0	0	0.013537	0	12	48										G	10186932	C	G	10186932	2	3	12	1	0	0	0	0	0	0	0	1	16880	813	29	1		1	UBE4B	1	10186932	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		10186932	239063689	1	2840										
MTOR	2475	broad.mit.edu	37	chr1	11297958	11297958	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagggttcatgctactgagtCggcccacagtgcagatggcc	13	12	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:11297958C>T	uc001asd.2	-	13	2271	c.2150G>A	c.(2149-2151)CGA>CAA	p.R717Q		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	717					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GCTACTGAGTCGGCCCACAGT	0.582													0	0	0	0.005443	0	25	57										T	11297958	C	T	11297958	3	4	12	1	0	0	0	0	1	0	0	0	9954	884	31	1	5683	1	MTOR	1	11297958	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1111026	11297958	237952663	2	2841										
VPS13D	55187	broad.mit.edu	37	chr1	12317111	12317111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggagaggcaggtgaagttccGaaggtggaaacccaaggtgg	18	6	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:12317111G>A	uc001atv.2	+	9	1049	c.908G>A	c.(907-909)CGA>CAA	p.R303Q	VPS13D_uc001atw.2_Missense_Mutation_p.R303Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	303					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GTGAAGTTCCGAAGGTGGAAA	0.443													0	0	0	0.004672	0	3	67										A	12317111	G	A	12317111	3	1	12	1	0	0	0	0	1	0	0	0	17189	1058	37	1	938	1	VPS13D	1	12317111	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1019153	12317111	236933510	3	2842										
TMEM50A	23585	broad.mit.edu	37	chr1	25678163	25678163	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccgaggtgatagttacagtGaaggttgtctgggtcaaaca	13	6	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:25678163G>A	uc001bke.2	+	4	403	c.253G>A	c.(253-255)GAA>AAA	p.E85K	TMEM50A_uc010oeq.1_Missense_Mutation_p.E85K|TMEM50A_uc009vrr.2_RNA|TMEM50A_uc009vrs.2_RNA	NM_014313	NP_055128	O95807	TM50A_HUMAN	small membrane protein 1	85						endoplasmic reticulum|integral to membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)		TAGTTACAGTGAAGGTTGTCT	0.368													0	0	0	0.001855	0	13	40										A	25678163	G	A	25678163	3	1	12	1	0	0	0	0	1	0	0	0	16172	1291	45	1	263	1	TMEM50A	1	25678163	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13361052	25678163	223572458	4	2843										
MAN1C1	57134	broad.mit.edu	37	chr1	26104650	26104650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gggggctgacctacattgccGagtggcgaggggggattctg	19	8	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:26104650G>A	uc001bkm.2	+	9	1642	c.1312G>A	c.(1312-1314)GAG>AAG	p.E438K	MAN1C1_uc009vry.1_Missense_Mutation_p.E258K|MAN1C1_uc001bkn.2_5'Flank	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	438	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		CTACATTGCCGAGTGGCGAGG	0.627													0	0	0	0.001168	0	4	62										A	26104650	G	A	26104650	3	1	12	1	0	0	0	0	1	0	0	0	9213	1059	37	1	1346	1	MAN1C1	1	26104650	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	426487	26104650	223145971	5	2844										
TRIM63	84676	broad.mit.edu	37	chr1	26387813	26387813	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cacatggggtgactgcccttCtgcagcggccgactgcagtg	14	13	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:26387813C>T	uc001bli.1	-	3	481	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q		NM_032588	NP_115977	Q969Q1	TRI63_HUMAN	muscle specific ring finger protein 1	115	Interaction with TTN.					cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GACTGCCCTTCTGCAGCGGCC	0.527													0	0	0	0.009096	0	3	66										T	26387813	C	T	26387813	2	4	12	1	0	0	0	0	0	0	0	1	16535	912	32	1		1	TRIM63	1	26387813	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	283163	26387813	222862808	6	2845										
ARID1A	8289	broad.mit.edu	37	chr1	27056160	27056160	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agccatccagtccaatggatCagatgggcaagatgagacct	11	10	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:27056160C>T	uc001bmv.1	+	2	1529	c.1156C>T	c.(1156-1158)CAG>TAG	p.Q386*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q386*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q386*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q3*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	386					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCCAATGGATCAGATGGGCAA	0.498			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.008361	0	27	91										T	27056160	C	T	27056160	4	4	12	1	0	0	0	0	0	1	0	0	913	827	29	1	1162	1	ARID1A	1	27056160	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	668347	27056160	222194461	7	2846										
PUM1	9698	broad.mit.edu	37	chr1	31437555	31437555	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaagaggatccatgtgaagaGagggaaggaggtggtgtctg	19	3	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:31437555G>A	uc001bsi.1	-	14	2402	c.2289C>T	c.(2287-2289)CTC>CTT	p.L763L	PUM1_uc001bsf.1_Silent_p.L429L|PUM1_uc001bsg.1_Intron|PUM1_uc001bsh.1_Silent_p.L763L|PUM1_uc001bsj.1_Silent_p.L737L|PUM1_uc010oga.1_Silent_p.L619L|PUM1_uc001bsk.1_Silent_p.L799L|PUM1_uc010ogb.1_Silent_p.L704L	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	763	Ser-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		CATGTGAAGAGAGGGAAGGAG	0.493													0	0	0	0.009535	0	29	176										A	31437555	G	A	31437555	2	1	12	1	0	0	0	0	0	0	0	1	12825	929	33	1		1	PUM1	1	31437555	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4381395	31437555	217813066	8	2847										
RLF	6018	broad.mit.edu	37	chr1	40701823	40701823	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgacactgccaccaacttttAggacaagaagcctcagattc	7	13	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:40701823A>G	uc001cfc.3	+	8	1480	c.1449A>G	c.(1447-1449)TTA>TTG	p.L483L	RLF_uc001cfd.3_Silent_p.L174L	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	483					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			ACCAACTTTTAGGACAAGAAG	0.403													0	0	0	0.009096	0	3	128										G	40701823	A	G	40701823	2	3	12	1	0	0	0	0	0	0	0	1	13389	417	15	5		5	RLF	1	40701823	Silent	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	9264268	40701823	208548798	9	2848										
IL12RB2	3595	broad.mit.edu	37	chr1	67792462	67792462	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tatcctgcatacagaagggaGaacaggggactgtggcctgc	14	9	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:67792462G>A	uc001ddu.2	+	4	1049	c.409G>A	c.(409-411)GAA>AAA	p.E137K	IL12RB2_uc010oqi.1_Missense_Mutation_p.E137K|IL12RB2_uc010oqj.1_Missense_Mutation_p.E137K|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.E137K|IL12RB2_uc010oqm.1_Missense_Mutation_p.E137K|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	137	Extracellular (Potential).|Fibronectin type-III 1.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						ACAGAAGGGAGAACAGGGGAC	0.428													0	0	0	0.008291	0	10	67										A	67792462	G	A	67792462	3	1	12	1	0	0	0	0	1	0	0	0	7627	943	33	1	419	1	IL12RB2	1	67792462	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	27090639	67792462	181458159	10	2849										
TTLL7	79739	broad.mit.edu	37	chr1	84403570	84403570	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaacttagcaacatcatgttGatttgcttgaaggaattctg	8	6	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:84403570G>C	uc001djc.2	-	8	1249	c.853C>G	c.(853-855)CAA>GAA	p.Q285E	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	285	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ACATCATGTTGATTTGCTTGA	0.373													0	0	0	0.00308	0	8	100										C	84403570	G	C	84403570	3	2	12	1	0	0	0	0	1	0	0	0	16729	1299	45	1	1866	1	TTLL7	1	84403570	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	16611108	84403570	164847051	11	2850										
LMO4	8543	broad.mit.edu	37	chr1	87797721	87797721	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggtgaatccgggcagcagctCgcagccgcccccggtgacgg	16	15	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:87797721C>T	uc001dmi.2	+	2	803	c.23C>T	c.(22-24)TCG>TTG	p.S8L	LMO4_uc001dmj.2_Missense_Mutation_p.S8L	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	8					neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		GGCAGCAGCTCGCAGCCGCCC	0.637													0	0	0	0.00308	0	6	53										T	87797721	C	T	87797721	3	4	12	1	0	0	0	0	1	0	0	0	8854	893	31	1	25	1	LMO4	1	87797721	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3394151	87797721	161452900	12	2851										
PKN2	5586	broad.mit.edu	37	chr1	89290038	89290038	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctagatacagagggctttgtGaaaattgctgattttggtct	11	5	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:89290038G>A	uc001dmn.2	+	18	2730	c.2388G>A	c.(2386-2388)GTG>GTA	p.V796V	PKN2_uc010osp.1_Silent_p.V780V|PKN2_uc010osq.1_Silent_p.V639V|PKN2_uc009wcv.2_Silent_p.V748V|PKN2_uc010osr.1_Silent_p.V461V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	796	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		AGGGCTTTGTGAAAATTGCTG	0.308													0	0	0	0.004482	0	8	54										A	89290038	G	A	89290038	2	1	12	1	0	0	0	0	0	0	0	1	11980	1277	45	1		1	PKN2	1	89290038	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1492317	89290038	159960583	13	2852										
ARHGAP29	9411	broad.mit.edu	37	chr1	94639451	94639451	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaattgtggaatttcaccttCgaggtcttcaaactgttgca	8	8	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:94639451C>T	uc001dqj.3	-	23	4129	c.3760G>A	c.(3760-3762)GAA>AAA	p.E1254K	ARHGAP29_uc009wdq.1_Intron	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	1254					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATTTCACCTTCGAGGTCTTCA	0.398													0	0	0	0.001855	0	13	106										T	94639451	C	T	94639451	3	4	12	1	0	0	0	0	1	0	0	0	878	893	31	1	29	1	ARHGAP29	1	94639451	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5349413	94639451	154611170	14	2853										
S1PR1	1901	broad.mit.edu	37	chr1	101705115	101705115	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagtgcgctgtccagctgctCcaccgtgctgccgctctacc	10	18	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:101705115C>G	uc001dud.2	+	2	1089	c.575C>G	c.(574-576)TCC>TGC	p.S192C	S1PR1_uc009weg.2_Missense_Mutation_p.S192C	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	192	Extracellular (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						TCCAGCTGCTCCACCGTGCTG	0.567											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003271	0	36	76										G	101705115	C	G	101705115	3	3	12	1	0	0	0	0	1	0	0	0	13793	855	30	1	577	1	S1PR1	1	101705115	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	7065664	101705115	147545506	15	2854										
KCNC4	3749	broad.mit.edu	37	chr1	110765682	110765682	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atatcgaccgcaacgtgacaGagatcctccgcgtagggaac	11	12	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:110765682G>C	uc001dzh.2	+	2	832	c.775G>C	c.(775-777)GAG>CAG	p.E259Q	KCNC4_uc001dzf.2_Missense_Mutation_p.E259Q|KCNC4_uc009wfr.2_Missense_Mutation_p.E259Q|KCNC4_uc001dzg.2_Missense_Mutation_p.E259Q|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	259					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CAACGTGACAGAGATCCTCCG	0.552													0	0	0	0.010504	0	21	129										C	110765682	G	C	110765682	3	2	12	1	0	0	0	0	1	0	0	0	8017	943	33	1	781	1	KCNC4	1	110765682	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	9060567	110765682	138484939	16	2855										
SPAG17	200162	broad.mit.edu	37	chr1	118640369	118640379	+	Frame_Shift_Del	DEL	AGATTTGTTTC	AGATTTGTTTC	-													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caagtcgagcaacatcaaagAgatttgtttcaggtttctca							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:118640369_118640379delAGATTTGTTTC	uc001ehk.2	-	7	993_1003	c.925_935delGAAACAAATCT	c.(925-936)GAAACAAATCTCfs	p.E309fs		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	309_312						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AACATCAAAGAGATTTGTTTCAGGTTTCTCA	0.374																		17	37	---	---								-	118640379	AGATTTGTTTC	-	118640369	7	5	12	1	0	1	0	1	0	0	0	0	14979	304	11	0	5904	0	SPAG17	1	118640369	Frame_Shift_Del	DEL	AGATTTGTTTC	TCGA-BT-A20R-01A-12D-A16O-08	7874687	118640369	130610252	17	2856										
PDE4DIP	9659	broad.mit.edu	37	chr1	144864265	144864265	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagctccttttccagctcttGaaggtgggatcgagaggaca	12	10	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:144864265G>C	uc001elw.3	-	36	6121	c.5830C>G	c.(5830-5832)CAA>GAA	p.Q1944E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.Q1838E|PDE4DIP_uc001elv.3_Missense_Mutation_p.Q951E|PDE4DIP_uc001ema.2_Missense_Mutation_p.Q131E	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1944	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCAGCTCTTGAAGGTGGGAT	0.527			T	PDGFRB	MPD								0	0	0	0.001855	0	12	303										C	144864265	G	C	144864265	3	2	12	1	0	0	0	0	1	0	0	0	11643	1299	45	1	1246	1	PDE4DIP	1	144864265	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	26223896	144864265	104386356	18	2857										
LINGO4	339398	broad.mit.edu	37	chr1	151773402	151773402	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cactggggaaggaaaggtcaGaagagcttggcagtgacccg	16	8	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:151773402G>C	uc001ezf.1	-	2	1969	c.1779C>G	c.(1777-1779)TTC>TTG	p.F593L		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	593	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAAGGTCAGAAGAGCTTGG	0.547													0	0	0	0.004007	0	17	59										C	151773402	G	C	151773402	3	2	12	1	0	0	0	0	1	0	0	0	8817	933	33	1	6	1	LINGO4	1	151773402	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	6909137	151773402	97477219	19	2858										
LINGO4	339398	broad.mit.edu	37	chr1	151774212	151774212	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccaggaggtggaaggcagtCaagccatggaaggcatgggc	17	8	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:151774212C>T	uc001ezf.1	-	2	1159	c.969G>A	c.(967-969)TTG>TTA	p.L323L		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	323	Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAGGCAGTCAAGCCATGGA	0.597													0	0	0	0.013537	0	13	71										T	151774212	C	T	151774212	2	4	12	1	0	0	0	0	0	0	0	1	8817	825	29	1		1	LINGO4	1	151774212	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	810	151774212	97476409	20	2859										
LCE3A	353142	broad.mit.edu	37	chr1	152595518	152595518	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctggaggcagacactgtgctGggctctttgcagggcacttg	15	10	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:152595518G>T	uc010pdt.1	-	1	62	c.62C>A	c.(61-63)CCA>CAA	p.P21Q		NM_178431	NP_848518	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	21					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACACTGTGCTGGGCTCTTTGC	0.632													1	0	4.4004e-07	0.00333	4.70313e-07	22	47										T	152595518	G	T	152595518	3	4	12	1	0	0	0	0	1	0	0	0	8669	1348	47	4	210	4	LCE3A	1	152595518	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	821306	152595518	96655103	21	2860										
S100A9	6280	broad.mit.edu	37	chr1	153333180	153333180	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggacctggacacaaatgcaGacaagcagctgagcttcgag	12	10	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:153333180G>A	uc001fbq.2	+	3	254	c.211G>A	c.(211-213)GAC>AAC	p.D71N		NM_002965	NP_002956	P06702	S10A9_HUMAN	S100 calcium-binding protein A9	71	2; high affinity (Probable).|EF-hand 2.				cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACAAATGCAGACAAGCAGCT	0.562													0	0	0	0.005524	0	37	53										A	153333180	G	A	153333180	3	1	12	1	0	0	0	0	1	0	0	0	13787	942	33	1	217	1	S100A9	1	153333180	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	737662	153333180	95917441	22	2861										
INTS3	65123	broad.mit.edu	37	chr1	153723691	153723691	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgacagaaggaagtagacttCtgcatctcactgcttcggga	11	10	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:153723691C>T	uc009wom.2	+	8	926	c.705C>T	c.(703-705)TTC>TTT	p.F235F	INTS3_uc001fct.2_Silent_p.F235F|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_Silent_p.F29F|INTS3_uc010peb.1_Silent_p.F29F|INTS3_uc001fcw.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	236					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAGTAGACTTCTGCATCTCAC	0.542													0	0	0	0.001984	0	7	72										T	153723691	C	T	153723691	2	4	12	1	0	0	0	0	0	0	0	1	7779	912	32	1		1	INTS3	1	153723691	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	390511	153723691	95526930	23	2862										
NES	10763	broad.mit.edu	37	chr1	156640874	156640874	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcagggtcctggaggccctCagcccctcccttcacactgg	10	17	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:156640874C>T	uc001fpq.2	-	4	3239	c.3106G>A	c.(3106-3108)GAG>AAG	p.E1036K		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1036	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGAGGCCCTCAGCCCCTCCC	0.667													0	0	0	0.010504	0	18	165										T	156640874	C	T	156640874	3	4	12	1	0	0	0	0	1	0	0	0	10337	835	29	1	1763	1	NES	1	156640874	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2917183	156640874	92609747	24	2863										
C1orf92	149499	broad.mit.edu	37	chr1	156897392	156897392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgcaaccggaccctcgtctCgctcaacctgggtttcaacc	8	17	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:156897392C>T	uc001fqm.2	+	7	939	c.767C>T	c.(766-768)TCG>TTG	p.S256L	C1orf92_uc001fql.2_Missense_Mutation_p.S41L	NM_144702	NP_653303	Q8N4P6	LRC71_HUMAN	hypothetical protein LOC149499	256	LRR 4.										0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACCCTCGTCTCGCTCAACCTG	0.662											OREG0013892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	11	9										T	156897392	C	T	156897392	3	4	12	1	0	0	0	0	1	0	0	0	2069	893	31	1	793	1	C1orf92	1	156897392	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	256518	156897392	92353229	25	2864										
CRP	1401	broad.mit.edu	37	chr1	159684367	159684367	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcaggggctagaagtcctaGatctcttgccttagagctac	10	10	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:159684367G>C	uc001ftw.2	-	1	13	c.-91C>G	c.(-93--89)ATCTA>ATGTA		CRP_uc001ftx.1_Translation_Start_Site|CRP_uc001fty.1_5'Flank	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor						acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AGAAGTCCTAGATCTCTTGCC	0.458													0	0	0	0.004672	0	3	12										C	159684367	G	C	159684367	1	2	12	1	0	0	0	0	0	0	0	0	3895	957	33	1		1	CRP	1	159684367	Translation_Start_Site	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	2786975	159684367	89566254	26	2865										
FCRLB	127943	broad.mit.edu	37	chr1	161697035	161697035	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	actgggcgtaatgcattcacAggttctcccctggacccggc	11	14	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:161697035A>T	uc001gbh.2	+	8	1100	c.866_splice	c.e8-2	p.G289_splice	FCRLB_uc009wus.2_Splice_Site_p.G289_splice|FCRLB_uc001gbj.2_Splice_Site_p.V241_splice|FCRLB_uc001gbk.2_Splice_Site_p.G254_splice|FCRLB_uc001gbl.2_Splice_Site_p.V234_splice|FCRLB_uc001gbm.2_Splice_Site_p.G247_splice|FCRLB_uc001gbi.2_Splice_Site_p.G289_splice|FCRLB_uc001gbn.3_Splice_Site_p.G291_splice	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B							endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ATGCATTCACAGGTTCTCCCC	0.507													0	0	0	0.009096	0	3	17										T	161697035	A	T	161697035	5	4	12	1	0	0	0	0	0	0	1	0	5801	202	7	5	886	5	FCRLB	1	161697035	Splice_Site	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	2012668	161697035	87553586	27	2866										
CFH	3075	broad.mit.edu	37	chr1	196694341	196694341	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggagaggtgttgaaattctCctgcaaaccaggatttacaa	10	7	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:196694341C>A	uc001gtj.3	+	12	2027	c.1787C>A	c.(1786-1788)TCC>TAC	p.S596Y		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	596	Sushi 10.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TTGAAATTCTCCTGCAAACCA	0.393													1	0	0.00307968	0.00308	0.00320493	7	41										A	196694341	C	A	196694341	3	1	12	1	0	0	0	0	1	0	0	0	3283	855	30	3	1851	3	CFH	1	196694341	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	34997306	196694341	52556280	28	2867										
CRB1	23418	broad.mit.edu	37	chr1	197411332	197411332	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatgagtgtgcctctgatccGtgtgtcaatggaggtctgtg	15	7	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:197411332G>T	uc001gtz.2	+	11	4050	c.3915G>T	c.(3913-3915)CCG>CCT	p.P1305P	CRB1_uc010poz.1_Silent_p.P1281P|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.P1193P|CRB1_uc010ppb.1_Silent_p.P769P|CRB1_uc010ppd.1_Silent_p.P786P|CRB1_uc001gub.1_3'UTR	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1305	Extracellular (Potential).|EGF-like 19; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.P1305A(1)		ovary(5)|skin(3)|large_intestine(1)	9						CCTCTGATCCGTGTGTCAATG	0.493													1	0	1.96642e-18	0.006999	2.14384e-18	41	164										T	197411332	G	T	197411332	2	4	12	1	0	0	0	0	0	0	0	1	3848	1132	40	4		4	CRB1	1	197411332	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	716991	197411332	51839289	29	2868										
PTPRC	5788	broad.mit.edu	37	chr1	198711037	198711037	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaagagaggtgactcacattCagttcaccagctggccagac	11	11	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:198711037C>T	uc001gur.1	+	24	2617	c.2437C>T	c.(2437-2439)CAG>TAG	p.Q813*	PTPRC_uc001gus.1_Nonsense_Mutation_p.Q765*|PTPRC_uc001gut.1_Nonsense_Mutation_p.Q652*	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	813	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						GACTCACATTCAGTTCACCAG	0.413													0	0	0	0.004672	0	3	32										T	198711037	C	T	198711037	4	4	12	1	0	0	0	0	0	1	0	0	12797	827	29	1	2538	1	PTPRC	1	198711037	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1299705	198711037	50539584	30	2869										
PHLDA3	23612	broad.mit.edu	37	chr1	201437671	201437671	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggggcagcggaagtcgatctCgccgcccccttcggtcacca	13	16	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:201437671C>T	uc001gwq.2	-	1	629	c.244G>A	c.(244-246)GAG>AAG	p.E82K	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	82	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						AAGTCGATCTCGCCGCCCCCT	0.652													0	0	0	0.006122	0	16	70										T	201437671	C	T	201437671	3	4	12	1	0	0	0	0	1	0	0	0	11850	893	31	1	143	1	PHLDA3	1	201437671	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2726634	201437671	47812950	31	2870										
PHLDA3	23612	broad.mit.edu	37	chr1	201437831	201437831	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcggtgaggacgcagcgcttCcgcttccacagctgcagcag	13	14	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:201437831C>T	uc001gwq.2	-	1	469	c.84G>A	c.(82-84)CGG>CGA	p.R28R	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	28	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						CGCAGCGCTTCCGCTTCCACA	0.721													0	0	0	0.001168	0	6	21										T	201437831	C	T	201437831	2	4	12	1	0	0	0	0	0	0	0	1	11850	842	30	1		1	PHLDA3	1	201437831	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	160	201437831	47812790	32	2871										
LMOD1	25802	broad.mit.edu	37	chr1	201915321	201915321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctccgtctggtttctctgccGcagccccacgggaacactcc	9	18	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:201915321G>A	uc001gxb.2	-	1	396	c.148C>T	c.(148-150)CGG>TGG	p.R50W	LMOD1_uc010ppu.1_Missense_Mutation_p.R50W	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	50					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						TTTCTCTGCCGCAGCCCCACG	0.587													0	0	0	0.013537	0	13	54										A	201915321	G	A	201915321	3	1	12	1	0	0	0	0	1	0	0	0	8856	1086	38	2	1666	2	LMOD1	1	201915321	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	477490	201915321	47335300	33	2872										
SLC45A3	85414	broad.mit.edu	37	chr1	205632625	205632625	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cttgggatgagaaagaggctCagcaggatgcccaaggacag	15	8	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:205632625C>T	uc001hda.1	-	3	633	c.294G>A	c.(292-294)CTG>CTA	p.L98L	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_5'UTR|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	98	Helical; Name=3; (Potential).				transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			GAAAGAGGCTCAGCAGGATGC	0.677			T	ETV1|ETV5|ELK4|ERG	prostate 								0	0	0	0.001984	0	6	30										T	205632625	C	T	205632625	2	4	12	1	0	0	0	0	0	0	0	1	14642	813	29	1		1	SLC45A3	1	205632625	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3717304	205632625	43617996	34	2873										
IKBKE	9641	broad.mit.edu	37	chr1	206653236	206653236	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctctggacgtccccaagttcGtccccaaagtggacctgcag	10	15	1	0	rs143491598		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:206653236G>A	uc001hdz.1	+	11	1575	c.1207G>A	c.(1207-1209)GTC>ATC	p.V403I	IKBKE_uc009xbv.1_Missense_Mutation_p.V403I|IKBKE_uc001hea.1_Missense_Mutation_p.V318I	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	403					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCCCAAGTTCGTCCCCAAAGT	0.592											OREG0014170	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	3	46										A	206653236	G	A	206653236	3	1	12	1	0	0	0	0	1	0	0	0	7612	1145	40	2	1241	2	IKBKE	1	206653236	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1020611	206653236	42597385	35	2874										
PFKFB2	5208	broad.mit.edu	37	chr1	207242832	207242832	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acccagaagagtttgcacttCgagatcaagagaagtatctg	10	8	2	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:207242832C>T	uc001hfg.2	+	11	1160	c.1051C>T	c.(1051-1053)CGA>TGA	p.R351*	PFKFB2_uc010psc.1_Nonsense_Mutation_p.R253*|PFKFB2_uc001hfh.2_Nonsense_Mutation_p.R351*|PFKFB2_uc009xcc.2_Nonsense_Mutation_p.R309*|PFKFB2_uc010psd.1_Nonsense_Mutation_p.R165*	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	351	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					GTTTGCACTTCGAGATCAAGA	0.463													0	0	0	0.001168	0	6	79										T	207242832	C	T	207242832	4	4	12	1	0	0	0	0	0	1	0	0	11761	876	31	1	1089	1	PFKFB2	1	207242832	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	589596	207242832	42007789	36	2875										
CENPF	1063	broad.mit.edu	37	chr1	214814564	214814564	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagaaagaaatgagttccatCatttctctaaataaaaggga	7	5	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:214814564C>T	uc001hkm.2	+	12	3057	c.2883C>T	c.(2881-2883)ATC>ATT	p.I961I		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	961	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGAGTTCCATCATTTCTCTAA	0.353													0	0	0	0.003163	0	14	63										T	214814564	C	T	214814564	2	4	12	1	0	0	0	0	0	0	0	1	3231	816	29	1		1	CENPF	1	214814564	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	7571732	214814564	34436057	37	2876										
SMYD3	64754	broad.mit.edu	37	chr1	246021899	246021899	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcgagcaccttcagctggtaGatgttgatatcgggaagccg	13	9	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:246021899G>C	uc001ibl.2	-	10	1070	c.975C>G	c.(973-975)ATC>ATG	p.I325M	SMYD3_uc001ibk.2_Missense_Mutation_p.I266M|SMYD3_uc001ibi.2_Missense_Mutation_p.I136M|SMYD3_uc001ibj.2_Missense_Mutation_p.I136M	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	325						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		TCAGCTGGTAGATGTTGATAT	0.507													0	0	0	0.009096	0	4	61										C	246021899	G	C	246021899	3	2	12	1	0	0	0	0	1	0	0	0	14823	932	33	1	323	1	SMYD3	1	246021899	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	31207335	246021899	3228722	38	2877										
CNST	163882	broad.mit.edu	37	chr1	246797846	246797846	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagaaaagggatttaatggtGaagattttgaacggcttacg	12	4	0	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:246797846G>A	uc001ibp.2	+	6	1153	c.775G>A	c.(775-777)GAA>AAA	p.E259K	CNST_uc001ibo.3_Missense_Mutation_p.E259K	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	259					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						ATTTAATGGTGAAGATTTTGA	0.333													0	0	0	0.001168	0	6	52										A	246797846	G	A	246797846	3	1	12	1	0	0	0	0	1	0	0	0	3634	1291	45	1	793	1	CNST	1	246797846	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	775947	246797846	2452775	39	2878										
ZNF496	84838	broad.mit.edu	37	chr1	247464049	247464049	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttggccttgccgttttccagCggctctttgggacccttgtc	11	13	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:247464049C>T	uc001ico.2	-	9	2001	c.1536G>A	c.(1534-1536)CCG>CCA	p.P512P	ZNF496_uc009xgv.2_Silent_p.P548P|ZNF496_uc001icp.2_Silent_p.P512P	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	512					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CGTTTTCCAGCGGCTCTTTGG	0.642													0	0	0	0.009096	0	4	110										T	247464049	C	T	247464049	2	4	12	1	0	0	0	0	0	0	0	1	17942	755	27	2		2	ZNF496	1	247464049	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	666203	247464049	1786572	40	2879										
OR2L8	391190	broad.mit.edu	37	chr1	248112934	248112934	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caccttttgtctacacttatCtacgtccaagatccctgcga	5	14	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:248112934C>G	uc001idt.1	+	1	775	c.775C>G	c.(775-777)CTA>GTA	p.L259V	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CTACACTTATCTACGTCCAAG	0.483													0	0	0	0.010818	0	25	73										G	248112934	C	G	248112934	3	3	12	1	0	0	0	0	1	0	0	0	11009	912	32	1	777	1	OR2L8	1	248112934	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	648885	248112934	1137687	41	2880										
OR2L3	391192	broad.mit.edu	37	chr1	248224758	248224758	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caccttttgtctacacttatCtacgtccaagatccctgcga	5	14	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr1:248224758C>G	uc001idx.1	+	1	775	c.775C>G	c.(775-777)CTA>GTA	p.L259V	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	259	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTACACTTATCTACGTCCAAG	0.493													0	0	0	0.004672	0	3	122										G	248224758	C	G	248224758	3	3	12	1	0	0	0	0	1	0	0	0	11008	912	32	1	777	1	OR2L3	1	248224758	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	111824	248224758	1025863	42	2881										
TSSC1	7260	broad.mit.edu	37	chr2	3197914	3197915	+	In_Frame_Ins	INS	-	-	CAT													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccgcaccagctgtccgtgggINScattctctatgcagtagatc							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:3197914_3197915insCAT	uc002qxj.2	-	7	869_870	c.676_677insATG	c.(676-678)GCC>GATGCC	p.225_226insD	TSSC1_uc002qxi.2_RNA	NM_003310	NP_003301	Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	225_226	WD 3.						protein binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		CTGTCCGTGGGCATTCTCTATG	0.515																		35	96	---	---								CAT	3197915	-	CAT	3197914	7	5	12	1	0	1	1	0	0	0	0	0	16663	1203	42	0	498	0	TSSC1	2	3197914	In_Frame_Ins	INS	-	TCGA-BT-A20R-01A-12D-A16O-08		3197914	240001459	43	2882										
ASAP2	8853	broad.mit.edu	37	chr2	9419502	9419502	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagaaatccgtgaaagcaatCaacagctctgggctgggtga	12	8	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:9419502C>G	uc002qzh.2	+	2	523	c.183C>G	c.(181-183)ATC>ATG	p.I61M	ASAP2_uc002qzi.2_Missense_Mutation_p.I61M	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	61					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						TGAAAGCAATCAACAGCTCTG	0.428													0	0	0	0.005443	0	23	35										G	9419502	C	G	9419502	3	3	12	1	0	0	0	0	1	0	0	0	1011	816	29	1	189	1	ASAP2	2	9419502	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	6221588	9419502	233779871	44	2883										
RAD51AP2	729475	broad.mit.edu	37	chr2	17696923	17696923	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atatataatgcagagtcattCtttctgtgaaaatcctttga	6	6	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:17696923C>G	uc002rcl.1	-	1	2784	c.2760G>C	c.(2758-2760)AAG>AAC	p.K920N	RAD51AP2_uc010exn.1_Missense_Mutation_p.K911N	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	920										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CAGAGTCATTCTTTCTGTGAA	0.289													0	0	0	0.006214	0	9	35										G	17696923	C	G	17696923	3	3	12	1	0	0	0	0	1	0	0	0	12987	912	32	1	731	1	RAD51AP2	2	17696923	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	8277421	17696923	225502450	45	2884										
C2orf16	84226	broad.mit.edu	37	chr2	27801569	27801569	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aatctaggacacgtgtgtcaGaatagggactgtcagaagtt	12	6	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:27801569G>C	uc002rkz.3	+	1	2181	c.2130G>C	c.(2128-2130)CAG>CAC	p.Q710H		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	710										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACGTGTGTCAGAATAGGGACT	0.418													0	0	0	0.012319	0	23	48										C	27801569	G	C	27801569	3	2	12	1	0	0	0	0	1	0	0	0	2157	933	33	1	2132	1	C2orf16	2	27801569	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	10104646	27801569	215397804	46	2885										
SLC30A6	55676	broad.mit.edu	37	chr2	32396442	32396442	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cttgtagcagctgaccgaagGgtaagttattccttaacccc	9	11	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:32396442G>C	uc002roe.1	+	2	127	c.90G>C	c.(88-90)AGG>AGC	p.R30S	SLC30A6_uc002rof.1_Missense_Mutation_p.R30S|SLC30A6_uc010ymw.1_Intron|SLC30A6_uc010ezr.1_Missense_Mutation_p.R30S|SLC30A6_uc002rog.1_5'UTR|SLC30A6_uc010ezs.1_Intron|SLC30A6_uc002roh.1_5'UTR	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	30	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTGACCGAAGGGTAAGTTATT	0.348													0	0	0	0.00308	0	7	36										C	32396442	G	C	32396442	3	2	12	1	0	0	0	0	1	0	0	0	14559	1246	43	4	96	4	SLC30A6	2	32396442	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4594873	32396442	210802931	47	2886										
PLEKHH2	130271	broad.mit.edu	37	chr2	43937144	43937144	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cttaggtgtgtctctctcctCtgtggcttctgaaagtgatt	10	9	4	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:43937144C>G	uc010yny.1	+	12	2065	c.1982C>G	c.(1981-1983)TCT>TGT	p.S661C	PLEKHH2_uc002rte.3_Missense_Mutation_p.S661C|PLEKHH2_uc002rtf.3_Missense_Mutation_p.S660C	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	661	Ser-rich.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCTCTCTCCTCTGTGGCTTCT	0.458													0	0	0	0.004482	0	8	166										G	43937144	C	G	43937144	3	3	12	1	0	0	0	0	1	0	0	0	12077	913	32	1	2024	1	PLEKHH2	2	43937144	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	11540702	43937144	199262229	48	2887										
CHAC2	494143	broad.mit.edu	37	chr2	54001597	54001597	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagaagaagcagatgagcatCttttcgctttggaaaaatta	9	6	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:54001597C>G	uc002rxk.1	+	3	585	c.490C>G	c.(490-492)CTT>GTT	p.L164V	ASB3_uc002rxg.1_Intron|ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_Intron	NM_001008708	NP_001008708	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator-like 2	164											0			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGATGAGCATCTTTTCGCTTT	0.348													0	0	0	0.00308	0	7	49										G	54001597	C	G	54001597	3	3	12	1	0	0	0	0	1	0	0	0	3309	913	32	1	500	1	CHAC2	2	54001597	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	10064453	54001597	189197776	49	2888										
C2orf78	388960	broad.mit.edu	37	chr2	74043855	74043855	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccactgctgtgaccagtctCcggtcactgcccaagcctca	8	17	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:74043855C>T	uc002sjr.1	+	3	2626	c.2505C>T	c.(2503-2505)CTC>CTT	p.L835L		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	835										ovary(2)	2						TGACCAGTCTCCGGTCACTGC	0.502													0	0	0	0.004007	0	14	79										T	74043855	C	T	74043855	2	4	12	1	0	0	0	0	0	0	0	1	2195	842	30	1		1	C2orf78	2	74043855	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	20042258	74043855	169155518	50	2889										
TSGA10	80705	broad.mit.edu	37	chr2	99721848	99721848	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aactgtacactccagctcctCtatcctttgttccaggtgag	7	13	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:99721848C>G	uc002szg.3	-	7	1061	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	TSGA10_uc002szh.3_Missense_Mutation_p.E145Q|TSGA10_uc002szi.3_Missense_Mutation_p.E145Q|TSGA10_uc010fin.1_Missense_Mutation_p.E145Q|TSGA10_uc010yvn.1_Missense_Mutation_p.E145Q	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	145					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						TCCAGCTCCTCTATCCTTTGT	0.338													0	0	0	0.004672	0	3	46										G	99721848	C	G	99721848	3	3	12	1	0	0	0	0	1	0	0	0	16614	922	32	1	1715	1	TSGA10	2	99721848	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	25677993	99721848	143477525	51	2890										
SLC9A4	389015	broad.mit.edu	37	chr2	103128724	103128724	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cactggagtcactaccaagtGagagacaagtaaggaggctg	13	8	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:103128724G>C	uc002tbz.3	+	7	2008	c.1551G>C	c.(1549-1551)GTG>GTC	p.V517V		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	517	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						ACTACCAAGTGAGAGACAAGT	0.398													0	0	0	0.010504	0	20	79										C	103128724	G	C	103128724	2	2	12	1	0	0	0	0	0	0	0	1	14716	1277	45	1		1	SLC9A4	2	103128724	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3406876	103128724	140070649	52	2891										
CNTNAP5	129684	broad.mit.edu	37	chr2	125367461	125367461	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcgactcagatggcagcggcCcactgggacctctccaggtg	13	14	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:125367461C>T	uc002tno.2	+	12	2201	c.1837C>T	c.(1837-1839)CCA>TCA	p.P613S	CNTNAP5_uc010flu.2_Missense_Mutation_p.P614S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	613	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGCAGCGGCCCACTGGGACC	0.522													0	0	0	0.000602	0	5	66										T	125367461	C	T	125367461	3	4	12	1	0	0	0	0	1	0	0	0	3650	623	22	2	1883	2	CNTNAP5	2	125367461	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	22238737	125367461	117831912	53	2892										
NEB	4703	broad.mit.edu	37	chr2	152470790	152470790	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agaatattagagccactcacAtcactctgcaggtcataggc	8	11	4	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:152470790A>G	uc010fnx.2	-	73	11063	c.10872T>C	c.(10870-10872)GAT>GAC	p.D3624D		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3624	Nebulin 99.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGCCACTCACATCACTCTGCA	0.338													0	0	0	0.012319	0	19	32										G	152470790	A	G	152470790	2	3	12	1	0	0	0	0	0	0	0	1	10302	231	8	5		5	NEB	2	152470790	Silent	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	27103329	152470790	90728583	54	2893										
DHRS9	10170	broad.mit.edu	37	chr2	169939948	169939948	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaagtgaacctgtttggactCatcagtgtgacactaaatat	9	7	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:169939948C>T	uc002uep.2	+	6	1927	c.423C>T	c.(421-423)CTC>CTT	p.L141L	DHRS9_uc002ueq.2_Silent_p.L141L|DHRS9_uc010zdc.1_Silent_p.L201L|DHRS9_uc010zdd.1_Silent_p.L141L|DHRS9_uc010zde.1_Silent_p.L141L	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	141					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						TGTTTGGACTCATCAGTGTGA	0.488													0	0	0	0.008291	0	11	73										T	169939948	C	T	169939948	2	4	12	1	0	0	0	0	0	0	0	1	4498	813	29	1		1	DHRS9	2	169939948	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	17469158	169939948	73259425	55	2894										
TTN	7273	broad.mit.edu	37	chr2	179413733	179413733	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcttgttttcacacatgcctCtgcattcaccttgtgccagt	6	13	4	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:179413733C>T	uc010zfg.1	-	288	85140	c.84916G>A	c.(84916-84918)GAG>AAG	p.E28306K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22001K|TTN_uc010zfi.1_Missense_Mutation_p.E21934K|TTN_uc010zfj.1_Missense_Mutation_p.E21809K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29233							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACATGCCTCTGCATTCACC	0.423													0	0	0	0.007413	0	18	83										T	179413733	C	T	179413733	3	4	12	1	0	0	0	0	1	0	0	0	16732	922	32	1	15455	1	TTN	2	179413733	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	9473785	179413733	63785640	56	2895										
TTN	7273	broad.mit.edu	37	chr2	179501355	179501355	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caaagattgctgaagagccaAcgaactctgattctgtcaag	9	9	3	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:179501355A>G	uc010zfg.1	-	174	33619	c.33395T>C	c.(33394-33396)GTT>GCT	p.V11132A	TTN_uc010zfh.1_Missense_Mutation_p.V4827A|TTN_uc010zfi.1_Missense_Mutation_p.V4760A|TTN_uc010zfj.1_Missense_Mutation_p.V4635A|TTN_uc010fre.1_Missense_Mutation_p.V993A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12059							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGAGCCAACGAACTCTGA	0.463													0	0	0	0.001168	0	6	63										G	179501355	A	G	179501355	3	3	12	1	0	0	0	0	1	0	0	0	16732	43	2	5	67146	5	TTN	2	179501355	Missense_Mutation	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	87622	179501355	63698018	57	2896										
STAT1	6772	broad.mit.edu	37	chr2	191839600	191839600	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cactatccgagacacctcgtCaaactcctcaggagacatgg	8	14	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:191839600C>G	uc002usj.2	-	24	2582	c.2194G>C	c.(2194-2196)GAC>CAC	p.D732H	STAT1_uc010fse.1_Missense_Mutation_p.D732H	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	732					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GACACCTCGTCAAACTCCTCA	0.493													0	0	0	0.001984	0	7	40										G	191839600	C	G	191839600	3	3	12	1	0	0	0	0	1	0	0	0	15263	826	29	1	66	1	STAT1	2	191839600	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	12338245	191839600	51359773	58	2897										
SDPR	8436	broad.mit.edu	37	chr2	192701173	192701173	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagcttgttcatctttttctCgatgttctggcgagaaaatg	9	8	4	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:192701173C>T	uc002utb.2	-	2	1084	c.754G>A	c.(754-756)GAG>AAG	p.E252K		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	252	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	ATCTTTTTCTCGATGTTCTGG	0.423													0	0	0	0.01441	0	84	186										T	192701173	C	T	192701173	3	4	12	1	0	0	0	0	1	0	0	0	13970	893	31	1	527	1	SDPR	2	192701173	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	861573	192701173	50498200	59	2898										
DNAH7	56171	broad.mit.edu	37	chr2	196671502	196671502	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acgaataataagcatcctttGaaactcatttgctttatctt	4	8	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:196671502G>C	uc002utj.3	-	54	10239	c.10138C>G	c.(10138-10140)CAA>GAA	p.Q3380E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3380					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGCATCCTTTGAAACTCATTT	0.383													0	0	0	0.004007	0	17	36										C	196671502	G	C	196671502	3	2	12	1	0	0	0	0	1	0	0	0	4606	1299	45	1	1984	1	DNAH7	2	196671502	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3970329	196671502	46527871	60	2899										
HECW2	57520	broad.mit.edu	37	chr2	197138838	197138838	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggtcctgcatgtcgagaatCttctcctacctgcaaacaga	8	12	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:197138838C>A	uc002utm.1	-	16	3328	c.3145G>T	c.(3145-3147)GAT>TAT	p.D1049Y	HECW2_uc002utl.1_Missense_Mutation_p.D693Y	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	1049	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						TGTCGAGAATCTTCTCCTACC	0.438													1	0	0.000219431	0.00245	0.000230006	14	24										A	197138838	C	A	197138838	3	1	12	1	0	0	0	0	1	0	0	0	7043	913	32	3	1629	3	HECW2	2	197138838	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	467336	197138838	46060535	61	2900										
RFTN2	130132	broad.mit.edu	37	chr2	198508944	198508944	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agaagttaggggacattcctCaatcacgagccttgggcgtc	12	10	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:198508944C>A	uc002uuo.3	-	3	778	c.376G>T	c.(376-378)GAG>TAG	p.E126*		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	126						plasma membrane					0						GGACATTCCTCAATCACGAGC	0.433													1	0	6.40141e-05	0.010729	6.74241e-05	10	39										A	198508944	C	A	198508944	4	1	12	1	0	0	0	0	0	1	0	0	13259	835	29	3	1157	3	RFTN2	2	198508944	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1370106	198508944	44690429	62	2901										
RFTN2	130132	broad.mit.edu	37	chr2	198508990	198508990	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccactgggtgctgccgaattCtttgggctgtaacagaggga	14	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:198508990C>G	uc002uuo.3	-	3	732	c.330G>C	c.(328-330)AAG>AAC	p.K110N		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	110						plasma membrane					0						CTGCCGAATTCTTTGGGCTGT	0.463													0	0	0	0.004482	0	9	29										G	198508990	C	G	198508990	3	3	12	1	0	0	0	0	1	0	0	0	13259	912	32	1	1203	1	RFTN2	2	198508990	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	46	198508990	44690383	63	2902										
BMPR2	659	broad.mit.edu	37	chr2	203420028	203420028	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggtccttatccagattattCttcctcctcatacattgaag	5	11	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:203420028C>T	uc002uzf.3	+	12	2788	c.1640C>T	c.(1639-1641)TCT>TTT	p.S547F	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	547	Poly-Ser.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						CCAGATTATTCTTCCTCCTCA	0.383													0	0	0	0.00245	0	15	24										T	203420028	C	T	203420028	3	4	12	1	0	0	0	0	1	0	0	0	1471	913	32	1	1686	1	BMPR2	2	203420028	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4911038	203420028	39779345	64	2903										
ADAM23	8745	broad.mit.edu	37	chr2	207310119	207310119	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagaatagcagcagtaatatCagttacagcaatgcaatgca	8	8	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:207310119C>T	uc002vbq.2	+	2	526	c.303C>T	c.(301-303)ATC>ATT	p.I101I	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	101					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		GCAGTAATATCAGTTACAGCA	0.413													0	0	0	0.000602	0	5	92										T	207310119	C	T	207310119	2	4	12	1	0	0	0	0	0	0	0	1	245	816	29	1		1	ADAM23	2	207310119	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3890091	207310119	35889254	65	2904										
ADAM23	8745	broad.mit.edu	37	chr2	207437917	207437917	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	attgtactggagactctggtCaggtatggcgcactgagttt	13	7	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:207437917C>G	uc002vbq.2	+	18	1958	c.1735C>G	c.(1735-1737)CAG>GAG	p.Q579E	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	579	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AGACTCTGGTCAGGTATGGCG	0.284													0	0	0	0.00632	0	27	63										G	207437917	C	G	207437917	3	3	12	1	0	0	0	0	1	0	0	0	245	827	29	1	1805	1	ADAM23	2	207437917	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	127798	207437917	35761456	66	2905										
CRYGB	1419	broad.mit.edu	37	chr2	209007482	209007482	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctccccctgtagttgggcatCtcatagaggatccagctgcc	10	14	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:209007482C>G	uc002vcp.3	-	3	441	c.408G>C	c.(406-408)GAG>GAC	p.E136D		NM_005210	NP_005201	P07316	CRGB_HUMAN	crystallin, gamma B	136	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		AGTTGGGCATCTCATAGAGGA	0.542													0	0	0	0.004289	0	34	81										G	209007482	C	G	209007482	3	3	12	1	0	0	0	0	1	0	0	0	3915	912	32	1	123	1	CRYGB	2	209007482	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1569565	209007482	34191891	67	2906										
STK16	8576	broad.mit.edu	37	chr2	220112206	220112206	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttaatggacttgggttccatGaatcaagcatgcatccatgt	9	8	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:220112206G>C	uc002vko.2	+	5	667	c.510G>C	c.(508-510)ATG>ATC	p.M170I	GLB1L_uc002vkm.2_5'Flank|GLB1L_uc002vkn.2_5'Flank|STK16_uc002vks.2_Missense_Mutation_p.M52I|STK16_uc010zky.1_Missense_Mutation_p.M170I|STK16_uc010fwf.2_Missense_Mutation_p.M170I|STK16_uc002vkp.2_Missense_Mutation_p.M170I|STK16_uc002vkr.2_Missense_Mutation_p.M103I|STK16_uc002vkq.2_Missense_Mutation_p.M215I	NM_001008910	NP_001008910	O75716	STK16_HUMAN	serine/threonine kinase 16	170	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGGTTCCATGAATCAAGCAT	0.507													0	0	0	0.008361	0	29	143										C	220112206	G	C	220112206	3	2	12	1	0	0	0	0	1	0	0	0	15288	1290	45	1	524	1	STK16	2	220112206	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	11104724	220112206	23087167	68	2907										
INHA	3623	broad.mit.edu	37	chr2	220437228	220437228	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttggatgccttggggcccccCgcggtgaccagggaaggtgg	18	11	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:220437228C>T	uc002vmk.1	+	1	276	c.132C>T	c.(130-132)CCC>CCT	p.P44P	OBSL1_uc010fwk.2_5'Flank|OBSL1_uc002vmi.2_5'Flank|OBSL1_uc002vmj.2_5'Flank	NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	44					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGGGGCCCCCCGCGGTGACCA	0.687											OREG0003991	type=REGULATORY REGION|Gene=BC045558|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.001984	0	7	10										T	220437228	C	T	220437228	2	4	12	1	0	0	0	0	0	0	0	1	7740	639	23	2		2	INHA	2	220437228	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	325022	220437228	22762145	69	2908										
WDR69	164781	broad.mit.edu	37	chr2	228771965	228771965	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttattgcaactgcttcagctGatggtaggtgatctgttcat	10	7	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:228771965G>C	uc002vpn.1	+	10	1049	c.970G>C	c.(970-972)GAT>CAT	p.D324H	WDR69_uc010zlw.1_Missense_Mutation_p.D309H|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	324	WD 6.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TGCTTCAGCTGATGGTAGGTG	0.373													0	0	0	0.000602	0	5	21										C	228771965	G	C	228771965	3	2	12	1	0	0	0	0	1	0	0	0	17316	1290	45	1	1008	1	WDR69	2	228771965	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8334737	228771965	14427408	70	2909										
SP100	6672	broad.mit.edu	37	chr2	231406036	231406036	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaatgtgaattcctcctcttGaaggtctactgtgattcgaa	8	8	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:231406036G>C	uc002vqu.1	+	27	2493	c.2352G>C	c.(2350-2352)TTG>TTC	p.L784F	SP100_uc010fxp.1_Missense_Mutation_p.L102F	NM_001080391	NP_001073860	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 1	Error:Variant_position_missing_in_P23497_after_alignment					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCCTCCTCTTGAAGGTCTACT	0.388													0	0	0	0.008291	0	8	45										C	231406036	G	C	231406036	3	2	12	1	0	0	0	0	1	0	0	0	14960	1281	45	1	3008	1	SP100	2	231406036	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	2634071	231406036	11793337	71	2910										
CAB39	51719	broad.mit.edu	37	chr2	231683405	231683405	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gggatttgaagagaccagctCagcaagaagcttaatctcca	10	9	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:231683405C>T	uc002vqx.2	+	9	1444	c.1012C>T	c.(1012-1014)CAG>TAG	p.Q338*	CAB39_uc010fxr.2_Nonsense_Mutation_p.Q338*|CAB39_uc010fxq.2_Nonsense_Mutation_p.Q338*|CAB39_uc002vqy.2_Nonsense_Mutation_p.Q93*	NM_016289	NP_057373	Q9Y376	CAB39_HUMAN	calcium binding protein 39	338					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)	1		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		GAGACCAGCTCAGCAAGAAGC	0.403													0	0	0	0.004482	0	8	12										T	231683405	C	T	231683405	4	4	12	1	0	0	0	0	0	1	0	0	2525	827	29	1	1042	1	CAB39	2	231683405	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	277369	231683405	11515968	72	2911										
UGT1A3	54659	broad.mit.edu	37	chr2	234637776	234637776	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccgtgtcttctgctgagatgGccacaggactccaggttccc	11	14	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:234637776G>A	uc002vuy.2	+	1	4	c.4G>A	c.(4-6)GCC>ACC	p.A2T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.A2T	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	2					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TGCTGAGATGGCCACAGGACT	0.572											OREG0003835	type=REGULATORY REGION|Gene=UGT1A3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004672	0	3	72										A	234637776	G	A	234637776	3	1	12	1	0	0	0	0	1	0	0	0	16943	1203	42	2	6	2	UGT1A3	2	234637776	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	2954371	234637776	8561597	73	2912										
ASB18	401036	broad.mit.edu	37	chr2	237103689	237103689	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gcaaagagggactggtagaaCggcttgtgcatctggaaggg	17	6	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:237103689C>T	uc010znh.1	-	6	1227	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P		NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	409	SOCS box.				intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		ACTGGTAGAACGGCTTGTGCA	0.542													0	0	0	0.001984	0	7	24										T	237103689	C	T	237103689	2	4	12	1	0	0	0	0	0	0	0	1	1022	523	19	2		2	ASB18	2	237103689	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2465913	237103689	6095684	74	2913										
COL6A3	1293	broad.mit.edu	37	chr2	238262009	238262009	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cacctctggtcccctgctctCcctcaaagcccggctggcca	8	20	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:238262009C>G	uc002vwl.2	-	25	6950	c.6665G>C	c.(6664-6666)GGA>GCA	p.G2222A	COL6A3_uc002vwo.2_Missense_Mutation_p.G2016A|COL6A3_uc010znj.1_Missense_Mutation_p.G1615A|COL6A3_uc002vwp.1_Missense_Mutation_p.G43A	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2222	Triple-helical region.|Collagen-like 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCCCTGCTCTCCCTCAAAGCC	0.478													0	0	0	0.013537	0	10	44										G	238262009	C	G	238262009	3	3	12	1	0	0	0	0	1	0	0	0	3701	855	30	1	2948	1	COL6A3	2	238262009	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1158320	238262009	4937364	75	2914										
KIF1A	547	broad.mit.edu	37	chr2	241706751	241706751	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gggtcctcgttcaggttgacGaggtgtggtgtctgcaggga	18	7	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr2:241706751G>C	uc002vzy.2	-	17	1628	c.1482C>G	c.(1480-1482)CTC>CTG	p.L494L	KIF1A_uc010fzk.2_Silent_p.L503L|KIF1A_uc002vzz.1_Silent_p.L503L	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	494					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TCAGGTTGACGAGGTGTGGTG	0.607													0	0	0	0.009096	0	3	19										C	241706751	G	C	241706751	2	2	12	1	0	0	0	0	0	0	0	1	8283	1045	37	1		1	KIF1A	2	241706751	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3444742	241706751	1492622	76	2915										
C3orf24	115795	broad.mit.edu	37	chr3	10146259	10146259	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agggtaacttgggactcactCcagattccaggaatgggctg	13	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:10146259C>T	uc003buz.2	-	2	425	c.200G>A	c.(199-201)GGA>GAA	p.G67E	C3orf24_uc003bva.1_Missense_Mutation_p.G67E	NM_173472	NP_775743	Q96PS1	CC024_HUMAN	hypothetical protein LOC115795	67											0				OV - Ovarian serous cystadenocarcinoma(96;0.196)		GGGACTCACTCCAGATTCCAG	0.557													0	0	0	0.001855	0	14	49										T	10146259	C	T	10146259	3	4	12	1	0	0	0	0	1	0	0	0	2217	855	30	1	337	1	C3orf24	3	10146259	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		10146259	187876171	77	2916										
VGLL4	9686	broad.mit.edu	37	chr3	11744444	11744444	+	Splice_Site	DEL	C	C	-													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tataatagactcctcacttaCgtttttcgtcatcagcatgc							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:11744444delC	uc003bwf.2	-	2	430	c.64_splice	c.e2+1	p.R22_splice	VGLL4_uc003bwg.2_Splice_Site	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		TCCTCACTTACGTTTTTCGTC	0.418																		13	16	---	---								-	11744444	C	-	11744444	8	5	12	1	0	1	0	1	0	0	1	0	17158	550	19	0	937	0	VGLL4	3	11744444	Splice_Site	DEL	C	TCGA-BT-A20R-01A-12D-A16O-08	1598185	11744444	186277986	78	2917										
ANKRD28	23243	broad.mit.edu	37	chr3	15726759	15726759	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agcaagcccagtgaagtgccGtatatccatgattgtctgct	10	10	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:15726759G>A	uc003caj.1	-	21	2416	c.2273C>T	c.(2272-2274)ACG>ATG	p.T758M	ANKRD28_uc003cai.1_Missense_Mutation_p.T604M|ANKRD28_uc011avz.1_Missense_Mutation_p.T604M|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.T788M|ANKRD28_uc003cam.2_Missense_Mutation_p.T791M	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	758	ANK 22.					nucleoplasm	protein binding			breast(1)	1						GTGAAGTGCCGTATATCCATG	0.423													0	0	0	0.009096	0	4	162										A	15726759	G	A	15726759	3	1	12	1	0	0	0	0	1	0	0	0	656	1145	40	2	920	2	ANKRD28	3	15726759	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3982315	15726759	182295671	79	2918										
TRANK1	9881	broad.mit.edu	37	chr3	36874249	36874249	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aacactctctgatggaaatgCttagggaaaaggacatccag	10	8	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:36874249C>G	uc003cgj.2	-	12	5345	c.5043G>C	c.(5041-5043)AAG>AAC	p.K1681N		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2231					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GATGGAAATGCTTAGGGAAAA	0.378													0	0	0	0.012213	0	32	57										G	36874249	C	G	36874249	3	3	12	1	0	0	0	0	1	0	0	0	16451	796	28	4	2096	4	TRANK1	3	36874249	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	21147490	36874249	161148181	80	2919										
SETD2	29072	broad.mit.edu	37	chr3	47162371	47162371	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctaagtttctgagctcttctGatgagtgcaagccatccaca	8	11	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:47162371G>A	uc003cqs.2	-	3	3808	c.3755C>T	c.(3754-3756)TCA>TTA	p.S1252L	SETD2_uc003cqv.2_Missense_Mutation_p.S1241L	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GAGCTCTTCTGATGAGTGCAA	0.453			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.008291	0	11	86										A	47162371	G	A	47162371	3	1	12	1	0	0	0	0	1	0	0	0	14131	1294	45	1	4015	1	SETD2	3	47162371	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	10288122	47162371	150860059	81	2920										
PTPN23	25930	broad.mit.edu	37	chr3	47447452	47447452	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagtgcgcagccggcgccttCgcctacctacgggagcactt	12	16	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:47447452C>T	uc003crf.1	+	6	558	c.462C>T	c.(460-462)TTC>TTT	p.F154F	PTPN23_uc011baw.1_Silent_p.F119F|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Silent_p.F24F	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	154	BRO1.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCGGCGCCTTCGCCTACCTAC	0.612													0	0	0	0.001984	0	7	22										T	47447452	C	T	47447452	2	4	12	1	0	0	0	0	0	0	0	1	12788	883	31	1		1	PTPN23	3	47447452	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	285081	47447452	150574978	82	2921										
CELSR3	1951	broad.mit.edu	37	chr3	48698212	48698212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagcatcctgcgccctgatgCgcaaggcatactctctctct	8	16	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:48698212C>T	uc003cul.2	-	1	2137	c.1856G>A	c.(1855-1857)CGC>CAC	p.R619H	CELSR3_uc003cuf.1_Missense_Mutation_p.R689H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	619	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGCCCTGATGCGCAAGGCATA	0.587													0	0	0	0.001168	0	6	25										T	48698212	C	T	48698212	3	4	12	1	0	0	0	0	1	0	0	0	3223	768	27	2	8222	2	CELSR3	3	48698212	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1250760	48698212	149324218	83	2922										
STAB1	23166	broad.mit.edu	37	chr3	52554987	52554987	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	accaccacctggaagcccagCtgctgccctggtcactatgg	10	16	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:52554987C>A	uc003dej.2	+	55	5948	c.5874C>A	c.(5872-5874)AGC>AGA	p.S1958R	STAB1_uc003dek.1_Translation_Start_Site|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1958	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGAAGCCCAGCTGCTGCCCTG	0.617													1	0	3.07112e-06	0.010729	3.25838e-06	12	17										A	52554987	C	A	52554987	3	1	12	1	0	0	0	0	1	0	0	0	15236	796	28	4	6092	4	STAB1	3	52554987	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3856775	52554987	145467443	84	2923										
MYH15	22989	broad.mit.edu	37	chr3	108179195	108179195	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaagctcctttctttcgtttCttctccccaaatggtatagc	6	12	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:108179195C>G	uc003dxa.1	-	18	2001	c.1944G>C	c.(1942-1944)AAG>AAC	p.K648N		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	648	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TCTTTCGTTTCTTCTCCCCAA	0.269													0	0	0	0.004672	0	3	15										G	108179195	C	G	108179195	3	3	12	1	0	0	0	0	1	0	0	0	10034	912	32	1	3996	1	MYH15	3	108179195	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	55624208	108179195	89843235	85	2924										
POLQ	10721	broad.mit.edu	37	chr3	121208086	121208086	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cacaattgatagtaacatttGagtctctatttatgtaacta	5	6	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:121208086G>C	uc003eee.3	-	16	3821	c.3692C>G	c.(3691-3693)TCA>TGA	p.S1231*	POLQ_uc003eed.2_Nonsense_Mutation_p.S403*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1231					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AGTAACATTTGAGTCTCTATT	0.333								DNA_polymerases_(catalytic_subunits)					0	0	0	0.012213	0	33	134										C	121208086	G	C	121208086	4	2	12	1	0	0	0	0	0	1	0	0	12208	1294	45	1	4140	1	POLQ	3	121208086	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13028891	121208086	76814344	86	2925										
KALRN	8997	broad.mit.edu	37	chr3	124066028	124066028	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaccatggtgaggcctttctCagcaaacacactggagttgg	11	10	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:124066028C>A	uc003ehg.2	+	10	1807	c.1680C>A	c.(1678-1680)CTC>CTA	p.L560L	KALRN_uc010hrv.1_Silent_p.L560L|KALRN_uc003ehf.1_Silent_p.L560L|KALRN_uc011bjy.1_Silent_p.L560L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	560	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGGCCTTTCTCAGCAAACACA	0.478													1	0	6.2361e-21	0.007835	6.81584e-21	36	141										A	124066028	C	A	124066028	2	1	12	1	0	0	0	0	0	0	0	1	7975	813	29	3		3	KALRN	3	124066028	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2857942	124066028	73956402	87	2926										
KALRN	8997	broad.mit.edu	37	chr3	124174160	124174160	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agatttctccctgaggatggGaaagtaccgatactcactgg	11	9	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:124174160G>C	uc003ehg.2	+	22	3810	c.3683G>C	c.(3682-3684)GGA>GCA	p.G1228A	KALRN_uc010hrv.1_Missense_Mutation_p.G1219A|KALRN_uc003ehf.1_Missense_Mutation_p.G1228A|KALRN_uc011bjy.1_Missense_Mutation_p.G1219A|KALRN_uc003ehh.1_Missense_Mutation_p.G574A	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1228					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTGAGGATGGGAAAGTACCGA	0.522													0	0	0	0.013537	0	12	79										C	124174160	G	C	124174160	3	2	12	1	0	0	0	0	1	0	0	0	7975	1174	41	1	3769	1	KALRN	3	124174160	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	108132	124174160	73848270	88	2927										
PPP2R3A	5523	broad.mit.edu	37	chr3	135721778	135721778	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttgagaaatcatttgttaatCtacctaaggaagactgtaaa	7	5	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:135721778C>G	uc003eqv.1	+	2	2003	c.1438C>G	c.(1438-1440)CTA>GTA	p.L480V	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	480					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						ATTTGTTAATCTACCTAAGGA	0.338													0	0	0	0.008291	0	11	58										G	135721778	C	G	135721778	3	3	12	1	0	0	0	0	1	0	0	0	12388	912	32	1	1440	1	PPP2R3A	3	135721778	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	11547618	135721778	62300652	89	2928										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.003163	0	16	67										A	178936091	G	A	178936091	3	1	12	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	43214313	178936091	19086339	90	2929										
FXR1	8087	broad.mit.edu	37	chr3	180693957	180693957	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccttcagaaaaggcaataaaCggcccaactagtgcttctgg	9	11	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:180693957C>T	uc003fkq.2	+	17	1765	c.1743C>T	c.(1741-1743)AAC>AAT	p.N581N	FXR1_uc003fkp.2_Silent_p.N496N|FXR1_uc003fkr.2_3'UTR|FXR1_uc011bqj.1_3'UTR|FXR1_uc003fks.2_Silent_p.N524N|FXR1_uc011bqk.1_3'UTR|FXR1_uc011bql.1_Silent_p.N568N	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	581					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			AGGCAATAAACGGCCCAACTA	0.393													0	0	0	0.00499	0	18	44										T	180693957	C	T	180693957	2	4	12	1	0	0	0	0	0	0	0	1	6115	535	19	2		2	FXR1	3	180693957	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1757866	180693957	17328473	91	2930										
MAP3K13	9175	broad.mit.edu	37	chr3	185191526	185191526	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gcacccctccagcgctacctCgaaaaacaaggcctctgcag	8	17	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr3:185191526C>T	uc010hyf.2	+	12	2673	c.2407C>T	c.(2407-2409)CGA>TGA	p.R803*	MAP3K13_uc011brt.1_Nonsense_Mutation_p.R596*|MAP3K13_uc011bru.1_Nonsense_Mutation_p.R659*|MAP3K13_uc003fpi.2_Nonsense_Mutation_p.R803*|MAP3K13_uc010hyg.2_Nonsense_Mutation_p.R493*	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	803					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGCGCTACCTCGAAAAACAAG	0.507													0	0	0	0.001855	0	11	213										T	185191526	C	T	185191526	4	4	12	1	0	0	0	0	0	1	0	0	9247	876	31	1	2445	1	MAP3K13	3	185191526	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4497569	185191526	12830904	92	2931										
PPP2R2C	5522	broad.mit.edu	37	chr4	6335373	6335373	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgggtgagcatgtagcggccGctgtggctgaacttcacgtc	15	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:6335373G>A	uc003gjc.2	-	7	1246	c.876C>T	c.(874-876)AGC>AGT	p.S292S	PPP2R2C_uc003gjb.2_Silent_p.S275S|PPP2R2C_uc011bwd.1_Silent_p.S285S|PPP2R2C_uc011bwe.1_Silent_p.S285S|PPP2R2C_uc003gja.2_Silent_p.S292S|PPP2R2C_uc003gjd.1_Silent_p.S380S	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	292	WD 5.				signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						TGTAGCGGCCGCTGTGGCTGA	0.562											OREG0016071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	19	82										A	6335373	G	A	6335373	2	1	12	1	0	0	0	0	0	0	0	1	12386	1078	38	2		2	PPP2R2C	4	6335373	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		6335373	184818903	93	2932										
PGM2	55276	broad.mit.edu	37	chr4	37848724	37848724	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttgccttaaaggaaggttttCattttgaggtagggtgtttc	12	4	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:37848724C>T	uc011byb.1	+	9	1253	c.1180C>T	c.(1180-1182)CAT>TAT	p.H394Y	PGM2_uc011bya.1_Missense_Mutation_p.H255Y|PGM2_uc011byc.1_Missense_Mutation_p.H234Y	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	394					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						GGAAGGTTTTCATTTTGAGGT	0.448													0	0	0	0.007291	0	28	79										T	37848724	C	T	37848724	3	4	12	1	0	0	0	0	1	0	0	0	11798	826	29	1	1214	1	PGM2	4	37848724	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	31513351	37848724	153305552	94	2933										
TBC1D1	23216	broad.mit.edu	37	chr4	38022296	38022296	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	attttgtctgttacgtgtttCagtgcacaaatgaggctctg	10	7	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:38022296C>T	uc003gtb.2	+	5	1400	c.1057C>T	c.(1057-1059)CAG>TAG	p.Q353*	TBC1D1_uc011byd.1_Nonsense_Mutation_p.Q353*|TBC1D1_uc010ifd.2_Intron|TBC1D1_uc011byf.1_Nonsense_Mutation_p.Q224*	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	353	PID.					nucleus	Rab GTPase activator activity			ovary(1)	1						TTACGTGTTTCAGTGCACAAA	0.478													0	0	0	0.003755	0	36	130										T	38022296	C	T	38022296	4	4	12	1	0	0	0	0	0	1	0	0	15594	827	29	1	1071	1	TBC1D1	4	38022296	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	173572	38022296	153131980	95	2934										
KLB	152831	broad.mit.edu	37	chr4	39448977	39448977	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagctgctgcggtgggtccgGaggaactacggcgacatgga	17	9	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:39448977G>C	uc003gua.2	+	4	2728	c.2631G>C	c.(2629-2631)CGG>CGC	p.R877R	KLB_uc011byj.1_Silent_p.R868R	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	877	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						GGTGGGTCCGGAGGAACTACG	0.622													0	0	0	0.008871	0	20	73										C	39448977	G	C	39448977	2	2	12	1	0	0	0	0	0	0	0	1	8332	1161	41	1		1	KLB	4	39448977	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1426681	39448977	151705299	96	2935										
GUF1	60558	broad.mit.edu	37	chr4	44680684	44680684	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgggggtgcgcacgcgctctCgcgccacgagccactggggc	17	15	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:44680684C>T	uc003gww.3	+	1	252	c.45C>T	c.(43-45)CTC>CTT	p.L15L	GUF1_uc010ifz.1_RNA	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	15					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						CACGCGCTCTCGCGCCACGAG	0.736													0	0	0	0.004672	0	3	9										T	44680684	C	T	44680684	2	4	12	1	0	0	0	0	0	0	0	1	6899	871	31	1		1	GUF1	4	44680684	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5231707	44680684	146473592	97	2936										
SCFD2	152579	broad.mit.edu	37	chr4	53751964	53751964	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atctttgaccattttcacttCagagactgtgaccccaccta	5	13	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:53751964C>T	uc003gzu.2	-	8	2046	c.1912G>A	c.(1912-1914)GAA>AAA	p.E638K	SCFD2_uc010igm.2_Missense_Mutation_p.E593K	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	638					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ATTTTCACTTCAGAGACTGTG	0.498													0	0	0	0.003163	0	15	42										T	53751964	C	T	53751964	3	4	12	1	0	0	0	0	1	0	0	0	13890	835	29	1	150	1	SCFD2	4	53751964	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	9071280	53751964	137402312	98	2937										
SMR3A	26952	broad.mit.edu	37	chr4	71232491	71232491	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccaccctatggtccagggaGatttccaccacccctttctc	6	17	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:71232491G>C	uc003hfg.1	+	3	266	c.185G>C	c.(184-186)AGA>ACA	p.R62T	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	62	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				GGTCCAGGGAGATTTCCACCA	0.547													0	0	0	0.000602	0	5	97										C	71232491	G	C	71232491	3	2	12	1	0	0	0	0	1	0	0	0	14811	942	33	1	191	1	SMR3A	4	71232491	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	17480527	71232491	119921785	99	2938										
ADAMTS3	9508	broad.mit.edu	37	chr4	73169687	73169687	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggtgtgaagactttcaatgtCatcttcaatgttataatccc	7	8	4	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:73169687C>T	uc003hgk.1	-	17	2408	c.2371G>A	c.(2371-2373)GAC>AAC	p.D791N	ADAMTS3_uc003hgl.2_Missense_Mutation_p.D132N	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	791	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CTTTCAATGTCATCTTCAATG	0.423													0	0	0	0.008871	0	21	97										T	73169687	C	T	73169687	3	4	12	1	0	0	0	0	1	0	0	0	267	826	29	1	1270	1	ADAMTS3	4	73169687	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1937196	73169687	117984589	100	2939										
C4orf22	255119	broad.mit.edu	37	chr4	81283911	81283911	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	actgattttctctctaggatGaaaccctggcccgccagttg	9	12	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:81283911G>A	uc003hmf.2	+	2	164	c.115G>A	c.(115-117)GAA>AAA	p.E39K	C4orf22_uc010ijp.2_Missense_Mutation_p.E39K	NM_152770	NP_689983	Q6V702	CD022_HUMAN	hypothetical protein LOC255119	39										skin(2)	2						TCTCTAGGATGAAACCCTGGC	0.433													0	0	0	0.004656	0	24	110										A	81283911	G	A	81283911	3	1	12	1	0	0	0	0	1	0	0	0	2255	1291	45	1	121	1	C4orf22	4	81283911	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8114224	81283911	109870365	101	2940										
ANK2	287	broad.mit.edu	37	chr4	114275389	114275389	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acattcacctgcgtcatcatCgagtaaaactgagaaacact	6	11	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:114275389C>T	uc003ibe.3	+	38	5715	c.5615C>T	c.(5614-5616)TCG>TTG	p.S1872L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.S1887L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1839	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCGTCATCATCGAGTAAAACT	0.453													0	0	0	0.003271	0	34	107										T	114275389	C	T	114275389	3	4	12	1	0	0	0	0	1	0	0	0	621	893	31	1	5830	1	ANK2	4	114275389	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	32991478	114275389	76878887	102	2941										
GUCY1A3	2982	broad.mit.edu	37	chr4	156634390	156634390	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atcccaattcacaatgcactGagggatgtggtcttaatagg	10	8	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr4:156634390G>A	uc003iov.2	+	8	1763	c.1227G>A	c.(1225-1227)CTG>CTA	p.L409L	GUCY1A3_uc010iqc.2_Silent_p.L409L|GUCY1A3_uc003iow.2_Silent_p.L409L|GUCY1A3_uc010iqd.2_Silent_p.L408L|GUCY1A3_uc003iox.2_Silent_p.L409L|GUCY1A3_uc003ioz.2_Silent_p.L174L|GUCY1A3_uc003ioy.2_Silent_p.L409L|GUCY1A3_uc010iqe.2_Silent_p.L174L|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.L409L	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	409					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ACAATGCACTGAGGGATGTGG	0.522													0	0	0	0.010729	0	12	29										A	156634390	G	A	156634390	2	1	12	1	0	0	0	0	0	0	0	1	6894	1277	45	1		1	GUCY1A3	4	156634390	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	42359001	156634390	34519886	103	2942										
ADCY2	108	broad.mit.edu	37	chr5	7743786	7743786	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttgtttcccggtagaacgtCcgtcctgggcatctcctttg	10	12	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:7743786C>T	uc003jdz.1	+	15	1944	c.1877C>T	c.(1876-1878)TCC>TTC	p.S626F	ADCY2_uc011cmo.1_Missense_Mutation_p.S446F	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	626					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGTAGAACGTCCGTCCTGGGC	0.493													0	0	0	0.013114	0	42	194										T	7743786	C	T	7743786	3	4	12	1	0	0	0	0	1	0	0	0	294	855	30	1	1935	1	ADCY2	5	7743786	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		7743786	173171474	104	2943										
PRDM9	56979	broad.mit.edu	37	chr5	23521274	23521274	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagtacctctggacagcactCaagactaaaactgggtaaga	9	9	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:23521274C>G	uc003jgo.2	+	6	676	c.494C>G	c.(493-495)TCA>TGA	p.S165*		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	165					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGACAGCACTCAAGACTAAAA	0.453										HNSCC(3;0.000094)			0	0	0	0.001855	0	14	69										G	23521274	C	G	23521274	4	3	12	1	0	0	0	0	0	1	0	0	12463	838	29	1	512	1	PRDM9	5	23521274	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	15777488	23521274	157393986	105	2944										
ANKRA2	57763	broad.mit.edu	37	chr5	72856967	72856967	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atacttacaatttgctaacaGaggtgtggtagagacctcat	9	7	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:72856967G>C	uc003kcu.1	-	3	1082	c.436C>G	c.(436-438)CTG>GTG	p.L146V	ANKRA2_uc003kcv.2_Missense_Mutation_p.L146V	NM_023039	NP_075526	Q9H9E1	ANRA2_HUMAN	ankyrin repeat, family A (RFXANK-like), 2	146						cytoskeleton|cytosol|membrane	low-density lipoprotein particle binding				0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)		OV - Ovarian serous cystadenocarcinoma(47;3.71e-54)		TTTGCTAACAGAGGTGTGGTA	0.343													0	0	0	0.00245	0	11	34										C	72856967	G	C	72856967	3	2	12	1	0	0	0	0	1	0	0	0	636	933	33	1	533	1	ANKRA2	5	72856967	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	49335693	72856967	108058293	106	2945										
RASGRF2	5924	broad.mit.edu	37	chr5	80369170	80369170	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcagagtacgttcaccagctCtacatcctggtcaatggctt	8	12	4	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:80369170C>T	uc003kha.1	+	5	786	c.786C>T	c.(784-786)CTC>CTT	p.L262L	RASGRF2_uc011ctn.1_RNA|RASGRF2_uc003khb.1_Silent_p.L90L	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	262	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TTCACCAGCTCTACATCCTGG	0.512													0	0	0	0.008291	0	9	43										T	80369170	C	T	80369170	2	4	12	1	0	0	0	0	0	0	0	1	13073	900	32	1		1	RASGRF2	5	80369170	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	7512203	80369170	100546090	107	2946										
MCC	4163	broad.mit.edu	37	chr5	112363128	112363128	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atctgcgactctaacttcttCagtttgttttgatgcttttt	6	8	4	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:112363128C>T	uc003kqj.3	-	17	2891	c.2361G>A	c.(2359-2361)CTG>CTA	p.L787L	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Silent_p.L977L	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	787					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTAACTTCTTCAGTTTGTTTT	0.448													0	0	0	0.001984	0	6	82										T	112363128	C	T	112363128	2	4	12	1	0	0	0	0	0	0	0	1	9373	813	29	1		1	MCC	5	112363128	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	31993958	112363128	68552132	108	2947										
ISOC1	51015	broad.mit.edu	37	chr5	128440990	128440990	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggtgtaaaactggtacttcCaaagaccaagttttcaatgg	9	7	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:128440990C>T	uc003kva.2	+	3	560	c.542C>T	c.(541-543)CCA>CTA	p.P181L		NM_016048	NP_057132	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	181						peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		CTGGTACTTCCAAAGACCAAG	0.398													0	0	0	0.004482	0	9	25										T	128440990	C	T	128440990	3	4	12	1	0	0	0	0	1	0	0	0	7862	594	21	2	552	2	ISOC1	5	128440990	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	16077862	128440990	52474270	109	2948										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139876702	139876702	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggttctaatgggacaaattCtcttgaacttcagaaagtat	8	6	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:139876702C>G	uc003lfs.1	+	15	2967	c.2843C>G	c.(2842-2844)TCT>TGT	p.S948C	ANKHD1_uc003lfq.1_Missense_Mutation_p.S967C|ANKHD1_uc003lfr.2_Missense_Mutation_p.S948C|ANKHD1_uc003lft.1_Intron|ANKHD1_uc003lfu.1_Missense_Mutation_p.S428C|ANKHD1_uc003lfv.1_Intron	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	948						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGACAAATTCTCTTGAACTT	0.428													0	0	0	0.009096	0	4	84										G	139876702	C	G	139876702	3	3	12	1	0	0	0	0	1	0	0	0	629	913	32	1	2901	1	ANKHD1-EIF4EBP3	5	139876702	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	11435712	139876702	41038558	110	2949										
PCDHGC4	56098	broad.mit.edu	37	chr5	140865104	140865104	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaatgtaccgagcagaggtaGagatcgtagatgtgaatgat	13	4	0	5			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:140865104G>C	uc003lky.1	+	1	364	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.E122Q	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	122	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGAGGTAGAGATCGTAGA	0.582													0	0	0	0.00308	0	5	83										C	140865104	G	C	140865104	3	2	12	1	0	0	0	0	1	0	0	0	11570	943	33	1	366	1	PCDHGC4	5	140865104	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	988402	140865104	40050156	111	2950										
PCDH12	51294	broad.mit.edu	37	chr5	141336615	141336615	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gccttggtcagggtctgtggCggtcagttttatgagaagcg	16	7	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:141336615C>T	uc003llx.2	-	1	2013	c.802G>A	c.(802-804)GCC>ACC	p.A268T		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	268	Extracellular (Potential).|Cadherin 3.				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTCTGTGGCGGTCAGTTTT	0.527													0	0	0	0.004656	0	25	35										T	141336615	C	T	141336615	3	4	12	1	0	0	0	0	1	0	0	0	11510	768	27	2	2768	2	PCDH12	5	141336615	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	471511	141336615	39578645	112	2951										
TCOF1	6949	broad.mit.edu	37	chr5	149758896	149758896	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gctacagcagctcaggcccaGacagggccagaggaggactc	14	13	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:149758896G>A	uc003lry.2	+	16	2691	c.2583G>A	c.(2581-2583)CAG>CAA	p.Q861Q	TCOF1_uc003lrw.2_Silent_p.Q861Q|TCOF1_uc011dch.1_Silent_p.Q861Q|TCOF1_uc003lrz.2_Silent_p.Q861Q|TCOF1_uc003lrx.2_Silent_p.Q784Q|TCOF1_uc003lsa.2_Silent_p.Q784Q|TCOF1_uc011dci.1_Intron	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	861					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCAGGCCCAGACAGGGCCAG	0.627													0	0	0	0.00278	0	25	37										A	149758896	G	A	149758896	2	1	12	1	0	0	0	0	0	0	0	1	15705	933	33	1		1	TCOF1	5	149758896	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8422281	149758896	31156364	113	2952										
FAT2	2196	broad.mit.edu	37	chr5	150925577	150925577	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggccagaatatgagttcataGagaagactccatccttattt	8	8	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:150925577G>C	uc003lue.3	-	9	5124	c.5111C>G	c.(5110-5112)TCT>TGT	p.S1704C	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1704	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAGTTCATAGAGAAGACTCC	0.448													0	0	0	0.003755	0	36	47										C	150925577	G	C	150925577	3	2	12	1	0	0	0	0	1	0	0	0	5690	942	33	1	7998	1	FAT2	5	150925577	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1166681	150925577	29989683	114	2953										
ODZ2	57451	broad.mit.edu	37	chr5	167626878	167626878	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcctctccaggttcttcatGaagaaatcgagctccctggt	8	12	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:167626878G>A	uc010jjd.2	+	17	3145	c.3145G>A	c.(3145-3147)GAA>AAA	p.E1049K	ODZ2_uc003lzr.3_Missense_Mutation_p.E826K|ODZ2_uc003lzt.3_Missense_Mutation_p.E422K|ODZ2_uc010jje.2_Missense_Mutation_p.E320K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GGTTCTTCATGAAGAAATCGA	0.488													0	0	0	0.01441	0	79	118										A	167626878	G	A	167626878	3	1	12	1	0	0	0	0	1	0	0	0	10835	1291	45	1	3211	1	ODZ2	5	167626878	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	16701301	167626878	13288382	115	2954										
ODZ2	57451	broad.mit.edu	37	chr5	167673915	167673915	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtaatatttacaacccgcctGaaagcaatgcttcggtcatc	7	11	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:167673915G>A	uc010jjd.2	+	27	5944	c.5944G>A	c.(5944-5946)GAA>AAA	p.E1982K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1752K|ODZ2_uc003lzt.3_Missense_Mutation_p.E1355K|ODZ2_uc010jje.2_Missense_Mutation_p.E1246K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CAACCCGCCTGAAAGCAATGC	0.557													0	0	0	0.008871	0	21	82										A	167673915	G	A	167673915	3	1	12	1	0	0	0	0	1	0	0	0	10835	1291	45	1	6050	1	ODZ2	5	167673915	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	47037	167673915	13241345	116	2955										
FAF2	23197	broad.mit.edu	37	chr5	175921066	175921066	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcatggagatgatcaccagGactctgatgagttttgtcgg	12	7	3	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr5:175921066G>T	uc003mej.3	+	6	603	c.550G>T	c.(550-552)GAC>TAC	p.D184Y		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	184					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						TGATCACCAGGACTCTGATGA	0.398													1	0	7.26314e-15	0.007291	7.89867e-15	28	62										T	175921066	G	T	175921066	3	4	12	1	0	0	0	0	1	0	0	0	5370	1174	41	3	572	3	FAF2	5	175921066	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8247151	175921066	4994194	117	2956										
DSP	1832	broad.mit.edu	37	chr6	7578018	7578018	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcattatgctgcaggattatGagctccagctggcctcatac	9	11	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:7578018G>C	uc003mxp.1	+	21	3163	c.2884G>C	c.(2884-2886)GAG>CAG	p.E962Q	DSP_uc003mxq.1_Missense_Mutation_p.E962Q	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	962	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCAGGATTATGAGCTCCAGCT	0.438													0	0	0	0.000602	0	5	93										C	7578018	G	C	7578018	3	2	12	1	0	0	0	0	1	0	0	0	4781	1291	45	1	2966	1	DSP	6	7578018	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		7578018	163537049	118	2957										
SNRNP48	154007	broad.mit.edu	37	chr6	7602962	7602962	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagaatgttcacataaccaaGaaatcatatactgaggtaag	7	6	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:7602962G>C	uc003mxr.2	+	6	761	c.702G>C	c.(700-702)AAG>AAC	p.K234N	SNRNP48_uc003mxs.2_RNA|SNRNP48_uc003mxt.1_5'UTR	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	234					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						ACATAACCAAGAAATCATATA	0.338													0	0	0	0.006214	0	9	27										C	7602962	G	C	7602962	3	2	12	1	0	0	0	0	1	0	0	0	14857	933	33	1	724	1	SNRNP48	6	7602962	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	24944	7602962	163512105	119	2958										
PHACTR1	221692	broad.mit.edu	37	chr6	13182823	13182823	+	Missense_Mutation	SNP	C	C	T													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cctgagctccagccagctgtCtctgcctgccctgtccgaaa							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:13182823C>T	uc010jpc.2	+	7	901	c.569C>T	c.(568-570)TCT>TTT	p.S190F	PHACTR1_uc011dir.1_Missense_Mutation_p.S190F|PHACTR1_uc003nag.1_Missense_Mutation_p.S190F|PHACTR1_uc003nah.1_Missense_Mutation_p.S190F	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	190						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			AGCCAGCTGTCTCTGCCTGCC	0.537													0	0	0	0.009096	0	4	234										T	13182823	C	T	13182823	3	4	12	1	0	0	0	0	1	0	0	0	11809	913	32	1	587	1	PHACTR1	6	13182823	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5579861	13182823	157932244	120	2959	18	2								
PHACTR1	221692	broad.mit.edu	37	chr6	13182825	13182825	+	Silent	SNP	C	C	T													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgagctccagccagctgtctCtgcctgccctgtccgaaatg							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:13182825C>T	uc010jpc.2	+	7	903	c.571C>T	c.(571-573)CTG>TTG	p.L191L	PHACTR1_uc011dir.1_Silent_p.L191L|PHACTR1_uc003nag.1_Silent_p.L191L|PHACTR1_uc003nah.1_Silent_p.L191L	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	191						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CCAGCTGTCTCTGCCTGCCCT	0.542													0	0	0	0.009096	0	4	228										T	13182825	C	T	13182825	2	4	12	1	0	0	0	0	0	0	0	1	11809	912	32	1		1	PHACTR1	6	13182825	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2	13182825	157932242	121	2960	18	2								
MBOAT1	154141	broad.mit.edu	37	chr6	20126922	20126922	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cttaagtattccaaaaaagaGggtttcactctgtgaaaata	7	6	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:20126922G>A	uc003ncx.1	-	7	745	c.540C>T	c.(538-540)CCC>CCT	p.P180P	MBOAT1_uc011dji.1_Silent_p.P31P	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	180	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			CCAAAAAAGAGGGTTTCACTC	0.338											OREG0017224	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	209										A	20126922	G	A	20126922	2	1	12	1	0	0	0	0	0	0	0	1	9356	987	35	2		2	MBOAT1	6	20126922	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	6944097	20126922	150988145	122	2961										
HIST1H1E	3008	broad.mit.edu	37	chr6	26156619	26156619	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgctcacgcttgccttcaacAtgtccgagactgcgcctgcc	9	17	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:26156619A>T	uc003ngq.2	+	1	61	c.1A>T	c.(1-3)ATG>TTG	p.M1L	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	1					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						TGCCTTCAACATGTCCGAGAC	0.672													0	0	0	0.001168	0	5	197										T	26156619	A	T	26156619	3	4	12	1	0	0	0	0	1	0	0	0	7126	217	8	5	3	5	HIST1H1E	6	26156619	Missense_Mutation	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	6029697	26156619	144958448	123	2962										
BTN3A1	11119	broad.mit.edu	37	chr6	26407948	26407948	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagggttacaaggatggaggGatccatctggagtgcaggtc	16	6	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:26407948G>T	uc003nhv.2	+	4	851	c.483G>T	c.(481-483)GGG>GGT	p.G161G	BTN3A1_uc011dkj.1_Silent_p.G161G|BTN3A1_uc011dkk.1_Intron|BTN3A1_uc010jqj.2_Silent_p.G161G	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	161	Ig-like V-type 2.|Extracellular (Potential).				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGGATGGAGGGATCCATCTGG	0.488													1	0	1.12685e-05	0.004482	1.18976e-05	9	118										T	26407948	G	T	26407948	2	4	12	1	0	0	0	0	0	0	0	1	1562	1161	41	3		3	BTN3A1	6	26407948	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	251329	26407948	144707119	124	2963										
C6orf15	29113	broad.mit.edu	37	chr6	31079483	31079483	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcccagggcctccacctcccCaggacacactgggattcagg	10	17	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:31079483C>T	uc003nsk.1	-	2	653	c.653G>A	c.(652-654)TGG>TAG	p.W218*		NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	218											0						TCCACCTCCCCAGGACACACT	0.612													0	0	0	0.004482	0	8	98										T	31079483	C	T	31079483	4	4	12	1	0	0	0	0	0	1	0	0	2336	595	21	2	328	2	C6orf15	6	31079483	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4671535	31079483	140035584	125	2964										
UHRF1BP1	54887	broad.mit.edu	37	chr6	34802629	34802629	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggcaggatccaaatagccctCaaaagaagagtaagtgtgtt	11	7	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:34802629C>G	uc003oju.3	+	6	894	c.660C>G	c.(658-660)CTC>CTG	p.L220L	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	220										ovary(3)	3						AAATAGCCCTCAAAAGAAGAG	0.438													0	0	0	0.009096	0	3	73										G	34802629	C	G	34802629	2	3	12	1	0	0	0	0	0	0	0	1	16965	813	29	1		1	UHRF1BP1	6	34802629	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3723146	34802629	136312438	126	2965										
DNAH8	1769	broad.mit.edu	37	chr6	38783350	38783350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgggggcaacagcaaatccGtcccatcaagtctgtcattc	9	13	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:38783350G>A	uc003ooe.1	+	24	3389	c.2789G>A	c.(2788-2790)CGT>CAT	p.R930H		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CAGCAAATCCGTCCCATCAAG	0.463													0	0	0	0.000602	0	5	32										A	38783350	G	A	38783350	3	1	12	1	0	0	0	0	1	0	0	0	4607	1145	40	2	2875	2	DNAH8	6	38783350	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3980721	38783350	132331717	127	2966										
GUCA1A	2978	broad.mit.edu	37	chr6	42146056	42146056	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atggagtacgtggcagcgctCagcttggtcctcaaggggaa	15	9	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:42146056C>A	uc003orx.2	+	4	885	c.240C>A	c.(238-240)CTC>CTA	p.L80L	GUCA1A_uc011duo.1_RNA|GUCA1A_uc010jxt.2_Silent_p.L80L	NM_000409	NP_000400	P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	80	EF-hand 2.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity				0	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGCAGCGCTCAGCTTGGTCC	0.622													1	0	2.12542e-12	0.00632	2.30563e-12	28	111										A	42146056	C	A	42146056	2	1	12	1	0	0	0	0	0	0	0	1	6888	813	29	3		3	GUCA1A	6	42146056	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3362706	42146056	128969011	128	2967										
GPR110	266977	broad.mit.edu	37	chr6	46977428	46977428	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atccattttacaacggggaaGattgtagaggggacaaaagg	13	5	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:46977428G>C	uc003oyt.2	-	11	1942	c.1743C>G	c.(1741-1743)ATC>ATG	p.I581M	GPR110_uc011dwl.1_Missense_Mutation_p.I269M	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	581	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CAACGGGGAAGATTGTAGAGG	0.438													0	0	0	0.013537	0	13	54										C	46977428	G	C	46977428	3	2	12	1	0	0	0	0	1	0	0	0	6627	932	33	1	1009	1	GPR110	6	46977428	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4831372	46977428	124137639	129	2968										
GPR110	266977	broad.mit.edu	37	chr6	46977848	46977848	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgatagctgtaaccccttttGagttggcttttgttcactgg	10	8	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:46977848G>A	uc003oyt.2	-	11	1522	c.1323C>T	c.(1321-1323)CTC>CTT	p.L441L	GPR110_uc011dwl.1_Silent_p.L129L	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	441	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						AACCCCTTTTGAGTTGGCTTT	0.438													0	0	0	0.008291	0	10	70										A	46977848	G	A	46977848	2	1	12	1	0	0	0	0	0	0	0	1	6627	1277	45	1		1	GPR110	6	46977848	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	420	46977848	124137219	130	2969										
PHF3	23469	broad.mit.edu	37	chr6	64421841	64421841	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgttgattggctgggagaatCaacctactactctggaatta	10	7	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:64421841C>T	uc003pep.1	+	15	4383	c.4357C>T	c.(4357-4359)CAA>TAA	p.Q1453*	PHF3_uc003pen.2_Nonsense_Mutation_p.Q1365*|PHF3_uc011dxs.1_Nonsense_Mutation_p.Q722*	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1453					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CTGGGAGAATCAACCTACTAC	0.448													0	0	0	0.00499	0	17	53										T	64421841	C	T	64421841	4	4	12	1	0	0	0	0	0	1	0	0	11836	827	29	1	4415	1	PHF3	6	64421841	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	17443993	64421841	106693226	131	2970										
IBTK	25998	broad.mit.edu	37	chr6	82891624	82891624	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttttggtgcctgagaattttCaattcctttaaaagaaactt	6	6	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:82891624C>G	uc003pjl.1	-	26	4224	c.3697G>C	c.(3697-3699)GAA>CAA	p.E1233Q	IBTK_uc011dyu.1_Missense_Mutation_p.E184Q|IBTK_uc011dyv.1_Missense_Mutation_p.E1218Q|IBTK_uc011dyw.1_Missense_Mutation_p.E1032Q|IBTK_uc010kbi.1_Missense_Mutation_p.E927Q	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	1233					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TGAGAATTTTCAATTCCTTTA	0.308													0	0	0	0.004672	0	3	27										G	82891624	C	G	82891624	3	3	12	1	0	0	0	0	1	0	0	0	7476	835	29	1	380	1	IBTK	6	82891624	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	18469783	82891624	88223443	132	2971										
KIAA1009	22832	broad.mit.edu	37	chr6	84925148	84925148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	taatgtgtccaatcccactcCgagactactatggttgagct	8	11	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:84925148C>T	uc010kbp.2	-	5	452	c.355G>A	c.(355-357)GGA>AGA	p.G119R	KIAA1009_uc003pkj.3_Missense_Mutation_p.G43R|KIAA1009_uc003pkk.2_Missense_Mutation_p.G119R	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	119					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		AATCCCACTCCGAGACTACTA	0.333													0	0	0	0.001984	0	5	18										T	84925148	C	T	84925148	3	4	12	1	0	0	0	0	1	0	0	0	8203	661	23	2	3948	2	KIAA1009	6	84925148	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2033524	84925148	86189919	133	2972										
RARS2	57038	broad.mit.edu	37	chr6	88299660	88299660	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctggcaagcaatagcgcggcGaaagccgcacgccatgtcca	12	14	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:88299660G>A	uc003pme.2	-	1	76	c.16C>T	c.(16-18)CGC>TGC	p.R6C	ORC3L_uc011dzl.1_5'Flank|ORC3L_uc011dzm.1_5'Flank|ORC3L_uc011dzn.1_5'Flank|ORC3L_uc003pmg.2_5'Flank|ORC3L_uc003pmh.2_5'Flank|ORC3L_uc003pmi.2_5'Flank|ORC3L_uc011dzo.1_5'Flank|ORC3L_uc011dzp.1_5'Flank|RARS2_uc003pmb.2_5'UTR|RARS2_uc003pmc.2_5'UTR|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	6					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		ATAGCGCGGCGAAAGCCGCAC	0.672											OREG0031911	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.004007	0	15	33										A	88299660	G	A	88299660	3	1	12	1	0	0	0	0	1	0	0	0	13059	1058	37	1	1800	1	RARS2	6	88299660	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3374512	88299660	82815407	134	2973										
LAMA4	3910	broad.mit.edu	37	chr6	112476811	112476811	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caaagcaaattctgctgtttCattggcttcactaacataat	5	9	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:112476811C>T	uc003pvu.2	-	15	2224	c.1915G>A	c.(1915-1917)GAA>AAA	p.E639K	LAMA4_uc003pvv.2_Missense_Mutation_p.E632K|LAMA4_uc003pvt.2_Missense_Mutation_p.E632K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	639	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TCTGCTGTTTCATTGGCTTCA	0.388													0	0	0	0.010729	0	10	61										T	112476811	C	T	112476811	3	4	12	1	0	0	0	0	1	0	0	0	8608	835	29	1	3656	1	LAMA4	6	112476811	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	24177151	112476811	58638256	135	2974										
C6orf174	387104	broad.mit.edu	37	chr6	127836879	127836879	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgcaaacggcaggggggccaGacaccggggagctgcggcta	18	12	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:127836879G>C	uc003qbd.2	-	2	1746	c.881C>G	c.(880-882)TCT>TGT	p.S294C		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	294						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		AGGGGGGCCAGACACCGGGGA	0.741													0	0	0	0.009096	0	4	23										C	127836879	G	C	127836879	3	2	12	1	0	0	0	0	1	0	0	0	2345	942	33	1	1986	1	C6orf174	6	127836879	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	15360068	127836879	43278188	136	2975										
MED23	9439	broad.mit.edu	37	chr6	131927625	131927625	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aacaaataacttactcatggTgaagtcttagggaatgaggt	10	5	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:131927625T>C	uc003qcs.1	-	13	1535	c.1361A>G	c.(1360-1362)CAC>CGC	p.H454R	MED23_uc003qcq.2_Missense_Mutation_p.H460R|MED23_uc011eca.1_Missense_Mutation_p.H95R|MED23_uc003qct.1_Missense_Mutation_p.H460R|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	454					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TTACTCATGGTGAAGTCTTAG	0.348													0	0	0	0.008291	0	8	36										C	131927625	T	C	131927625	3	2	12	1	0	0	0	0	1	0	0	0	9441	1696	59	5	2820	5	MED23	6	131927625	Missense_Mutation	SNP	T	TCGA-BT-A20R-01A-12D-A16O-08	4090746	131927625	39187442	137	2976										
CNKSR3	154043	broad.mit.edu	37	chr6	154754641	154754641	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	catttccgctacaaagcaatCctaaagaaggggatggagaa	10	8	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr6:154754641C>G	uc003qpy.2	-	5	1013	c.508G>C	c.(508-510)GAT>CAT	p.D170H		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	170	CRIC.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		ACAAAGCAATCCTAAAGAAGG	0.368													0	0	0	0.004672	0	3	7										G	154754641	C	G	154754641	3	3	12	1	0	0	0	0	1	0	0	0	3608	869	30	1	1195	1	CNKSR3	6	154754641	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	22827016	154754641	16360426	138	2977										
MAD1L1	8379	broad.mit.edu	37	chr7	2269702	2269702	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agagcctccctccacacgctGagagatgaagttgttcaaag	10	11	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:2269702G>A	uc003slh.1	-	3	333	c.67C>T	c.(67-69)CAG>TAG	p.Q23*	MAD1L1_uc003slf.1_Nonsense_Mutation_p.Q23*|MAD1L1_uc003slg.1_Nonsense_Mutation_p.Q23*|MAD1L1_uc010ksh.1_Nonsense_Mutation_p.Q23*|MAD1L1_uc003sli.1_Intron|MAD1L1_uc010ksi.1_Nonsense_Mutation_p.Q23*|MAD1L1_uc010ksj.2_Nonsense_Mutation_p.Q23*	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	23					cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCCACACGCTGAGAGATGAAG	0.532													0	0	0	0.001168	0	6	12										A	2269702	G	A	2269702	4	1	12	1	0	0	0	0	0	1	0	0	9147	1299	45	1	2157	1	MAD1L1	7	2269702	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		2269702	156868961	139	2978										
AIMP2	7965	broad.mit.edu	37	chr7	6054965	6054965	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	accaccaatgcgctggacttGaattcagtgcttgggaaggt	12	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:6054965G>C	uc003spo.2	+	2	437	c.324G>C	c.(322-324)TTG>TTC	p.L108F		NM_006303	NP_006294	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting	108	Interaction with PARK2.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			ovary(1)	1						CGCTGGACTTGAATTCAGTGC	0.458													0	0	0	0.008291	0	11	48										C	6054965	G	C	6054965	3	2	12	1	0	0	0	0	1	0	0	0	434	1281	45	1	330	1	AIMP2	7	6054965	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3785263	6054965	153083698	140	2979										
DNAH11	8701	broad.mit.edu	37	chr7	21603941	21603941	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccatctgtctgatctggagtCattccaagttttataacacc	6	11	4	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:21603941C>G	uc003svc.2	+	6	1151	c.1120C>G	c.(1120-1122)CAT>GAT	p.H374D		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	374	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GATCTGGAGTCATTCCAAGTT	0.413									Kartagener_syndrome				0	0	0	0.001984	0	7	41										G	21603941	C	G	21603941	3	3	12	1	0	0	0	0	1	0	0	0	4599	826	29	1	1142	1	DNAH11	7	21603941	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	15548976	21603941	137534722	141	2980										
HOXA1	3198	broad.mit.edu	37	chr7	27135004	27135010	+	Frame_Shift_Del	DEL	ATACGTA	ATACGTA	-													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agaggggacaaggagttattAtacgtagccagggccaggct							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:27135004_27135010delATACGTA	uc003sye.2	-	1	616_622	c.522_528delTACGTAT	c.(520-528)GCTACGTATfs	p.A174fs	HOXA1_uc003syd.2_Intron|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	174_176						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						AGGAGTTATTATACGTAGCCAGGGCCA	0.58																		51	129	---	---								-	27135010	ATACGTA	-	27135004	7	5	12	1	0	1	0	1	0	0	0	0	7288	456	16	0	487	0	HOXA1	7	27135004	Frame_Shift_Del	DEL	ATACGTA	TCGA-BT-A20R-01A-12D-A16O-08	5531063	27135004	132003659	142	2981										
GLI3	2737	broad.mit.edu	37	chr7	42187951	42187951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cttgatcaatgaggccctctCgtcactcgatgttgaaggtt	10	10	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:42187951C>T	uc011kbh.1	-	3	332	c.241G>A	c.(241-243)GAG>AAG	p.E81K	GLI3_uc011kbg.1_Missense_Mutation_p.E22K	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	81					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GAGGCCCTCTCGTCACTCGAT	0.552									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.001168	0	6	36										T	42187951	C	T	42187951	3	4	12	1	0	0	0	0	1	0	0	0	6439	893	31	1	4553	1	GLI3	7	42187951	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	15052947	42187951	116950712	143	2982										
PKD1L1	168507	broad.mit.edu	37	chr7	47876633	47876633	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cggctggaggagggcctgctGtacaccgacagccagacatg	15	12	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:47876633G>A	uc003tny.1	-	37	5829	c.5829C>T	c.(5827-5829)TAC>TAT	p.Y1943Y		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1943	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AGGGCCTGCTGTACACCGACA	0.577													0	0	0	0.009096	0	3	43										A	47876633	G	A	47876633	2	1	12	1	0	0	0	0	0	0	0	1	11964	1372	48	2		2	PKD1L1	7	47876633	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	5688682	47876633	111262030	144	2983										
ZNF273	10793	broad.mit.edu	37	chr7	64363703	64363703	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcttcactgctctatgtcctCtgctcctagaggtccacctt	6	15	4	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:64363703C>T	uc003tto.2	+	1	84	c.8C>T	c.(7-9)TCT>TTT	p.S3F	ZNF273_uc003ttl.2_Intron|ZNF273_uc003ttm.1_RNA|ZNF273_uc003ttn.2_5'UTR|ZNF273_uc003ttp.1_RNA	NM_021148	NP_066971	Q14593	ZN273_HUMAN	zinc finger protein 273	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TCTATGTCCTCTGCTCCTAGA	0.592													0	0	0	0.013537	0	13	37										T	64363703	C	T	64363703	3	4	12	1	0	0	0	0	1	0	0	0	17805	913	32	1	10	1	ZNF273	7	64363703	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	16487070	64363703	94774960	145	2984										
DNAJC30	84277	broad.mit.edu	37	chr7	73097498	73097498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgtgaagcgctcggcggcctCcgcgctcccggagttgcggt	16	15	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:73097498C>T	uc003tys.1	-	1	284	c.256G>A	c.(256-258)GAG>AAG	p.E86K	WBSCR22_uc010lbi.1_5'Flank|WBSCR22_uc003tyt.2_5'Flank|WBSCR22_uc003tyu.2_5'Flank|WBSCR22_uc003tyv.2_5'Flank|WBSCR22_uc003tyw.1_5'Flank	NM_032317	NP_115693	Q96LL9	DJC30_HUMAN	DnaJ (Hsp40) homolog subfamily C member 30	86	J.				protein folding		heat shock protein binding|unfolded protein binding				0						TCGGCGGCCTCCGCGCTCCCG	0.662													0	0	0	0.008871	0	20	70										T	73097498	C	T	73097498	3	4	12	1	0	0	0	0	1	0	0	0	4648	864	30	1	428	1	DNAJC30	7	73097498	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	8733795	73097498	86041165	146	2985										
PCLO	27445	broad.mit.edu	37	chr7	82544005	82544005	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttgaggcccaatttaccttCactgtctgacatggcatgtt	8	10	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:82544005C>G	uc003uhx.2	-	7	13586	c.13297G>C	c.(13297-13299)GAA>CAA	p.E4433Q	PCLO_uc003uhv.2_Missense_Mutation_p.E4433Q|PCLO_uc010lec.2_Missense_Mutation_p.E1398Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4364					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AATTTACCTTCACTGTCTGAC	0.418													0	0	0	0.000602	0	5	20										G	82544005	C	G	82544005	3	3	12	1	0	0	0	0	1	0	0	0	11583	835	29	1	2224	1	PCLO	7	82544005	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	9446507	82544005	76594658	147	2986										
CDK14	5218	broad.mit.edu	37	chr7	90741917	90741917	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctcctacaatgttccccaaaGaacagactgtcggcacaggc	8	14	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:90741917G>C	uc003uky.2	+	13	1437	c.1215G>C	c.(1213-1215)AAG>AAC	p.K405N	CDK14_uc003ukz.1_Missense_Mutation_p.K387N|CDK14_uc010les.1_Missense_Mutation_p.K359N|CDK14_uc011khl.1_Missense_Mutation_p.K276N	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	405	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						GTTCCCCAAAGAACAGACTGT	0.502													0	0	0	0.009096	0	4	112										C	90741917	G	C	90741917	3	2	12	1	0	0	0	0	1	0	0	0	3130	933	33	1	1207	1	CDK14	7	90741917	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8197912	90741917	68396746	148	2987										
PTCD1	26024	broad.mit.edu	37	chr7	99057790	99057790	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagctcccccagtttgacctCcagaagtttcttgtccttca	6	15	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:99057790C>G	uc011kiw.1	-	2	84	c.40G>C	c.(40-42)GAG>CAG	p.E14Q	ATP5J2_uc003uql.2_Missense_Mutation_p.E14Q|ATP5J2_uc003uqm.2_Missense_Mutation_p.E20Q|ATP5J2_uc003uqn.2_Missense_Mutation_p.E14Q|ATP5J2_uc003uqo.2_Missense_Mutation_p.E20Q	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	Error:Variant_position_missing_in_O75127_after_alignment										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AGTTTGACCTCCAGAAGTTTC	0.483													0	0	0	0.009535	0	30	157										G	99057790	C	G	99057790	3	3	12	1	0	0	0	0	1	0	0	0	12727	864	30	1		1	PTCD1	7	99057790	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	8315873	99057790	60080873	149	2988										
RELN	5649	broad.mit.edu	37	chr7	103322663	103322663	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaaattgaactcgctgccttCatttccatggaaataaatgg	7	8	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:103322663C>T	uc003vca.2	-	11	1349	c.1189G>A	c.(1189-1191)GAA>AAA	p.E397K	RELN_uc010liz.2_Missense_Mutation_p.E397K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	397					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCGCTGCCTTCATTTCCATGG	0.458													0	0	0	0.001984	0	4	88										T	103322663	C	T	103322663	3	4	12	1	0	0	0	0	1	0	0	0	13220	835	29	1	9413	1	RELN	7	103322663	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4264873	103322663	55816000	150	2989										
SLC26A3	1811	broad.mit.edu	37	chr7	107408296	107408296	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggattgttaagaaaaatattGagcttttcacttcaccatca	6	7	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:107408296G>A	uc003ver.2	-	19	2331	c.2120C>T	c.(2119-2121)TCA>TTA	p.S707L	SLC26A3_uc003ves.2_Missense_Mutation_p.S594L	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	707	Helical; (Potential).|STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						GAAAAATATTGAGCTTTTCAC	0.323													0	0	0	0.00308	0	8	26										A	107408296	G	A	107408296	3	1	12	1	0	0	0	0	1	0	0	0	14518	1294	45	1	186	1	SLC26A3	7	107408296	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4085633	107408296	51730367	151	2990										
PPP1R3A	5506	broad.mit.edu	37	chr7	113558970	113558970	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttggaaagtaacttcttcatCttcacaaagagagtcagata	7	7	5	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:113558970C>T	uc010ljy.1	-	1	113	c.82G>A	c.(82-84)GAT>AAT	p.D28N		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	28					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ACTTCTTCATCTTCACAAAGA	0.398													0	0	0	0.014323	0	21	56										T	113558970	C	T	113558970	3	4	12	1	0	0	0	0	1	0	0	0	12371	913	32	1	3302	1	PPP1R3A	7	113558970	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	6150674	113558970	45579693	152	2991										
TES	26136	broad.mit.edu	37	chr7	115890320	115890320	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caaagcagctccctgcacatGaccaggacccttcaaagtgc	8	15	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:115890320G>A	uc003vho.2	+	4	653	c.472G>A	c.(472-474)GAC>AAC	p.D158N	TES_uc011kmy.1_Intron|TES_uc003vhp.2_Missense_Mutation_p.D149N|uc003vhq.1_5'Flank	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	158	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			CCCTGCACATGACCAGGACCC	0.532													0	0	0	0.004482	0	9	53										A	115890320	G	A	115890320	3	1	12	1	0	0	0	0	1	0	0	0	15762	1290	45	1	486	1	TES	7	115890320	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	2331350	115890320	43248343	153	2992										
TAS2R16	50833	broad.mit.edu	37	chr7	122635437	122635437	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggatattaaaaaattcccaGgtgattgttaagttgcaaag	9	4	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:122635437G>A	uc003vkl.1	-	1	318	c.252C>T	c.(250-252)ACC>ACT	p.T84T		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	84	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						AAAATTCCCAGGTGATTGTTA	0.398													0	0	0	0.001984	0	7	30										A	122635437	G	A	122635437	2	1	12	1	0	0	0	0	0	0	0	1	15566	987	35	2		2	TAS2R16	7	122635437	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	6745117	122635437	36503226	154	2993										
NRF1	4899	broad.mit.edu	37	chr7	129394931	129394931	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagggcaacggaccagtgcaGgtggccatggcccctgtgac	15	13	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:129394931G>A	uc003voz.2	+	11	1539	c.1422G>A	c.(1420-1422)CAG>CAA	p.Q474Q	NRF1_uc003vpa.2_Silent_p.Q493Q|NRF1_uc011kpa.1_Silent_p.Q313Q|NRF1_uc003vpb.2_Silent_p.Q474Q	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	474	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GACCAGTGCAGGTGGCCATGG	0.592													0	0	0	0.006214	0	10	42										A	129394931	G	A	129394931	2	1	12	1	0	0	0	0	0	0	0	1	10646	991	35	2		2	NRF1	7	129394931	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	6759494	129394931	29743732	155	2994										
CLCN1	1180	broad.mit.edu	37	chr7	143039095	143039095	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgcttcgaattaacgggtcaGattgctcacatcctgcccat	8	12	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr7:143039095G>C	uc003wcr.1	+	15	1743	c.1656G>C	c.(1654-1656)CAG>CAC	p.Q552H	CLCN1_uc011ktc.1_Missense_Mutation_p.Q164H	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	552			Q -> R (in THD, MCR and in myotonia levior).		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TAACGGGTCAGATTGCTCACA	0.532													0	0	0	0.00333	0	23	45										C	143039095	G	C	143039095	3	2	12	1	0	0	0	0	1	0	0	0	3462	933	33	1	1714	1	CLCN1	7	143039095	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13644164	143039095	16099568	156	2995										
SGK223	157285	broad.mit.edu	37	chr8	8175696	8175697	+	Nonsense_Mutation	DNP	TC	TC	AT													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcacagaagctgcaggagctTcagcgactgtaagagggccc							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:8175696_8175697TC>AT	uc003wsh.3	-	5	4188_4189	c.4188_4189GA>AT	c.(4186-4191)CTGAAG>CTATAG	p.K1397*		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1397							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TGCAGGAGCTTCAGCGACTGTA	0.658													0	0	0	0.004672	0	8	29										AT	8175697	TC	AT	8175696	4	1	12	1	0	0	0	0	0	1	0	0	14210	1792	62	5	23	5	SGK223	8	8175696	Nonsense_Mutation	DNP	TC	TCGA-BT-A20R-01A-12D-A16O-08		8175696	138188326	157	2996										
SLC7A2	6542	broad.mit.edu	37	chr8	17401171	17401171	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtacacctacgtgactgtcgGagagctgtgggccttcatca	12	11	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:17401171G>C	uc011kyc.1	+	2	492	c.323G>C	c.(322-324)GGA>GCA	p.G108A	SLC7A2_uc011kyd.1_Missense_Mutation_p.G148A|SLC7A2_uc011kye.1_Missense_Mutation_p.G148A|SLC7A2_uc011kyf.1_Missense_Mutation_p.G108A	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	108	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	GTGACTGTCGGAGAGCTGTGG	0.493													0	0	0	0.008871	0	18	28										C	17401171	G	C	17401171	3	2	12	1	0	0	0	0	1	0	0	0	14697	1174	41	1	449	1	SLC7A2	8	17401171	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	9225475	17401171	128962851	158	2997										
KCNU1	157855	broad.mit.edu	37	chr8	36642013	36642013	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agatccaagcagcattcattCtctcttcctttgtgaccttc	5	13	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:36642013C>T	uc010lvw.2	+	1	172	c.85C>T	c.(85-87)CTC>TTC	p.L29F	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	29	Helical; Name=Segment S0; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AGCATTCATTCTCTCTTCCTT	0.423													0	0	0	0.000602	0	5	37										T	36642013	C	T	36642013	3	4	12	1	0	0	0	0	1	0	0	0	8093	913	32	1	87	1	KCNU1	8	36642013	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	19240842	36642013	109722009	159	2998										
RAB11FIP1	80223	broad.mit.edu	37	chr8	37729403	37729403	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccgtcatcttcaacctgatCtattctttcatcatccgatg	4	13	7	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:37729403C>G	uc003xkm.1	-	4	2961	c.2917G>C	c.(2917-2919)GAT>CAT	p.D973H	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.D302H|RAB11FIP1_uc003xko.1_Missense_Mutation_p.D302H|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	973					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCAACCTGATCTATTCTTTCA	0.458													0	0	0	0.006214	0	10	67										G	37729403	C	G	37729403	3	3	12	1	0	0	0	0	1	0	0	0	12893	913	32	1	946	1	RAB11FIP1	8	37729403	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1087390	37729403	108634619	160	2999			1	11		3	3	826	C		4.293439e-05
RAB11FIP1	80223	broad.mit.edu	37	chr8	37729766	37729766	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtggggagactcaggaggctCtccgtcagacgcgtttccag	15	11	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:37729766C>G	uc003xkm.1	-	4	2598	c.2554G>C	c.(2554-2556)GAG>CAG	p.E852Q	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.E181Q|RAB11FIP1_uc003xko.1_Missense_Mutation_p.E181Q|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	852					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCAGGAGGCTCTCCGTCAGAC	0.637													0	0	0	0.006214	0	7	40										G	37729766	C	G	37729766	3	3	12	1	0	0	0	0	1	0	0	0	12893	922	32	1	1309	1	RAB11FIP1	8	37729766	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	363	37729766	108634256	161	3000			1	11		3	3	826	C		4.293439e-05
RAB11FIP1	80223	broad.mit.edu	37	chr8	37730228	37730228	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcctcttgtcgccctgtttCaggctgctctgggagagact	11	12	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:37730228C>G	uc003xkm.1	-	4	2136	c.2092G>C	c.(2092-2094)GAA>CAA	p.E698Q	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.E27Q|RAB11FIP1_uc003xko.1_Missense_Mutation_p.E27Q|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	698					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CGCCCTGTTTCAGGCTGCTCT	0.527													0	0	0	0.010729	0	11	43										G	37730228	C	G	37730228	3	3	12	1	0	0	0	0	1	0	0	0	12893	835	29	1	1771	1	RAB11FIP1	8	37730228	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	462	37730228	108633794	162	3001			1	11		3	3	826	C		4.293439e-05
ADAM2	2515	broad.mit.edu	37	chr8	39613416	39613416	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	catatttacatattaattttCcgcactgcagattgctataa	4	8	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:39613416C>G	uc003xnj.2	-	16	1703	c.1628G>C	c.(1627-1629)GGA>GCA	p.G543A	ADAM2_uc003xnk.2_Missense_Mutation_p.G524A|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	543	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TATTAATTTTCCGCACTGCAG	0.244													0	0	0	0.00308	0	8	54										G	39613416	C	G	39613416	3	3	12	1	0	0	0	0	1	0	0	0	241	855	30	1	599	1	ADAM2	8	39613416	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1883188	39613416	106750606	163	3002										
RUNX1T1	862	broad.mit.edu	37	chr8	92972521	92972521	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gttcccggggtggttgacctCggagtggctgctggtggtgt	19	8	0	1	rs144186445		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:92972521C>T	uc003yfd.2	-	11	1848	c.1764G>A	c.(1762-1764)CCG>CCA	p.P588P	RUNX1T1_uc003yfc.1_Silent_p.P561P|RUNX1T1_uc003yfe.1_Silent_p.P551P|RUNX1T1_uc010mao.2_Silent_p.P561P|RUNX1T1_uc011lgi.1_Silent_p.P599P|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Silent_p.P213P|RUNX1T1_uc003yfb.1_Silent_p.P551P	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	588					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGGTTGACCTCGGAGTGGCTG	0.612													0	0	0	0.009096	0	4	12										T	92972521	C	T	92972521	2	4	12	1	0	0	0	0	0	0	0	1	13747	871	31	1		1	RUNX1T1	8	92972521	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	53359105	92972521	53391501	164	3003										
FBXO43	286151	broad.mit.edu	37	chr8	101149855	101149855	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccgatttgcatttttatcttGaacaacaatttcacgccaat	4	10	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:101149855G>C	uc003yjd.2	-	3	2325	c.1612C>G	c.(1612-1614)CAA>GAA	p.Q538E	FBXO43_uc003yje.2_Missense_Mutation_p.Q504E|FBXO43_uc010mbp.1_Missense_Mutation_p.Q538E	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	538	F-box.				meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TTTTTATCTTGAACAACAATT	0.299													0	0	0	0.004007	0	15	28										C	101149855	G	C	101149855	3	2	12	1	0	0	0	0	1	0	0	0	5752	1299	45	1	526	1	FBXO43	8	101149855	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8177334	101149855	45214167	165	3004										
ABRA	137735	broad.mit.edu	37	chr8	107782327	107782327	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcgcccactgctgccaacctCgggccaagctgatgaccagg	11	16	0	2	rs148182297		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:107782327C>G	uc003ymm.3	-	1	146	c.92G>C	c.(91-93)CGA>CCA	p.R31P		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	31					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CTGCCAACCTCGGGCCAAGCT	0.647													0	0	0	0.008291	0	8	83										G	107782327	C	G	107782327	3	3	12	1	0	0	0	0	1	0	0	0	100	884	31	1	1061	1	ABRA	8	107782327	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	6632472	107782327	38581695	166	3005										
ZNF696	79943	broad.mit.edu	37	chr8	144377992	144377992	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gctcagagcacggagcctgcCgcagaggcaggcgctcccga	15	15	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr8:144377992C>A	uc003yxy.3	+	3	556	c.147C>A	c.(145-147)GCC>GCA	p.A49A		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CGGAGCCTGCCGCAGAGGCAG	0.672													1	0	0.004672	0.004672	0.00485041	2	3										A	144377992	C	A	144377992	2	1	12	1	0	0	0	0	0	0	0	1	18096	639	23	4		4	ZNF696	8	144377992	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	36595665	144377992	1986030	167	3006										
IFNA7	3444	broad.mit.edu	37	chr9	21202054	21202054	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atttgtgccaggagtatcaaGgccctcctattacgcaggct	10	11	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:21202054G>C	uc003zop.1	-	1	151	c.111C>G	c.(109-111)GCC>GCG	p.A37A	IFNA14_uc003zoo.1_Intron	NM_021057	NP_066401	P01567	IFNA7_HUMAN	interferon, alpha 7 precursor	37					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGAGTATCAAGGCCCTCCTAT	0.502													0	0	0	0.00333	0	22	121										C	21202054	G	C	21202054	2	2	12	1	0	0	0	0	0	0	0	1	7542	987	35	4		4	IFNA7	9	21202054	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		21202054	120011377	168	3007										
MURC	347273	broad.mit.edu	37	chr9	103348453	103348453	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaaggaagcttttaagatgcGcagcctcaggaaaggtaagg	13	6	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:103348453G>A	uc004bba.2	+	2	905	c.815G>A	c.(814-816)CGC>CAC	p.R272H		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	272					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				TTTAAGATGCGCAGCCTCAGG	0.537													0	0	0	0.00632	0	25	104										A	103348453	G	A	103348453	3	1	12	1	0	0	0	0	1	0	0	0	9987	1087	38	2	821	2	MURC	9	103348453	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	82146399	103348453	37864978	169	3008										
PPP3R2	5535	broad.mit.edu	37	chr9	104357001	104357001	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	attccttgaagtccacttctCcatcaccgtcggtgtcgaag	8	13	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:104357001C>G	uc004bbr.2	-	1	283	c.212G>C	c.(211-213)GGA>GCA	p.G71A	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_Intron	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	68	EF-hand 2.|2.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	GTCCACTTCTCCATCACCGTC	0.577													0	0	0	0.00245	0	15	86										G	104357001	C	G	104357001	3	3	12	1	0	0	0	0	1	0	0	0	12401	855	30	1	313	1	PPP3R2	9	104357001	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1008548	104357001	36856430	170	3009										
CEP110	11064	broad.mit.edu	37	chr9	123932082	123932082	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atccagcggagccagctggaGaaaaaccttcttgtgagtac	11	10	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:123932082G>C	uc004bkx.1	+	37	6295	c.6264G>C	c.(6262-6264)GAG>GAC	p.E2088D	CEP110_uc004blb.1_Missense_Mutation_p.E757D|CEP110_uc010mvp.1_Missense_Mutation_p.E38D	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	2088	Required for centrosome localization.|Sufficient for interaction with HOOK2.|Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GCCAGCTGGAGAAAAACCTTC	0.443													0	0	0	0.004672	0	3	81										C	123932082	G	C	123932082	3	2	12	1	0	0	0	0	1	0	0	0	3245	933	33	1	6410	1	CEP110	9	123932082	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	19575081	123932082	17281349	171	3010										
OR1J2	26740	broad.mit.edu	37	chr9	125273495	125273495	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acactgtcatcatgagggaaGagctctgtgtcttcttagtg	11	8	5	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:125273495G>C	uc004bmj.1	+	4	1270	c.415G>C	c.(415-417)GAG>CAG	p.E139Q	OR1J2_uc011lyv.1_Missense_Mutation_p.E139Q	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						CATGAGGGAAGAGCTCTGTGT	0.478													0	0	0	0.00308	0	8	51										C	125273495	G	C	125273495	3	2	12	1	0	0	0	0	1	0	0	0	10960	943	33	1	417	1	OR1J2	9	125273495	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1341413	125273495	15939936	172	3011										
GOLGA1	2800	broad.mit.edu	37	chr9	127693663	127693663	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gctgggatgaaagatcttctCtggagctgcttccatcggaa	12	9	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:127693663C>G	uc004bpc.2	-	4	500	c.158G>C	c.(157-159)AGA>ACA	p.R53T	GOLGA1_uc010mwt.1_Missense_Mutation_p.R53T	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	53	Potential.					Golgi cisterna membrane				ovary(1)	1						AAGATCTTCTCTGGAGCTGCT	0.433													0	0	0	0.010504	0	19	87										G	127693663	C	G	127693663	3	3	12	1	0	0	0	0	1	0	0	0	6551	913	32	1	2225	1	GOLGA1	9	127693663	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2420168	127693663	13519768	173	3012										
SCAI	286205	broad.mit.edu	37	chr9	127734000	127734000	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caatatcacggttgatttttCgaagatattcttgacacttt	6	7	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:127734000C>T	uc004bpe.2	-	16	1604	c.1523G>A	c.(1522-1524)CGA>CAA	p.R508Q	SCAI_uc004bpd.2_Missense_Mutation_p.R531Q|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	508					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						GTTGATTTTTCGAAGATATTC	0.408													0	0	0	0.003954	0	24	96										T	127734000	C	T	127734000	3	4	12	1	0	0	0	0	1	0	0	0	13869	884	31	1	309	1	SCAI	9	127734000	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	40337	127734000	13479431	174	3013										
SPTAN1	6709	broad.mit.edu	37	chr9	131388736	131388736	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acagctggtttgaaaatgcaGaggaggacttaacagacccc	11	9	0	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:131388736G>A	uc004bvl.3	+	48	6444	c.6331G>A	c.(6331-6333)GAG>AAG	p.E2111K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E2116K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E2091K|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2111	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAAATGCAGAGGAGGACTT	0.567													0	0	0	0.00499	0	18	137										A	131388736	G	A	131388736	3	1	12	1	0	0	0	0	1	0	0	0	15116	943	33	1	6536	1	SPTAN1	9	131388736	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3654736	131388736	9824695	175	3014										
CARD9	64170	broad.mit.edu	37	chr9	139266398	139266398	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtcgctgagcacctgctcctCatcatcggggttcaggacct	11	14	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:139266398C>T	uc004chg.3	-	2	299	c.133G>A	c.(133-135)GAG>AAG	p.E45K	CARD9_uc011mdw.1_Missense_Mutation_p.E45K|CARD9_uc011mdx.1_5'UTR|CARD9_uc010nbj.2_Missense_Mutation_p.E45K	NM_052813	NP_434700	Q9H257	CARD9_HUMAN	caspase recruitment domain protein 9 isoform 1	45	CARD.				positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			pancreas(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		ACCTGCTCCTCATCATCGGGG	0.637													0	0	0	0.00632	0	30	161										T	139266398	C	T	139266398	3	4	12	1	0	0	0	0	1	0	0	0	2652	835	29	1	1578	1	CARD9	9	139266398	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	7877662	139266398	1947033	176	3015										
C9orf172	389813	broad.mit.edu	37	chr9	139741083	139741083	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caccgcgctttctcgcgcatCgcgcgtgtcggcttcctgtc	11	17	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr9:139741083C>T	uc011meh.1	+	1	2217	c.2217C>T	c.(2215-2217)ATC>ATT	p.I739I	PHPT1_uc004cjp.2_5'Flank|PHPT1_uc011mei.1_5'Flank|PHPT1_uc004cjq.3_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	739											0						TCTCGCGCATCGCGCGTGTCG	0.706													0	0	0	0.004482	0	9	9										T	139741083	C	T	139741083	2	4	12	1	0	0	0	0	0	0	0	1	2471	874	31	1		1	C9orf172	9	139741083	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	474685	139741083	1472348	177	3016										
ASB13	79754	broad.mit.edu	37	chr10	5691004	5691004	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgtgcagaggggtcccaaaaTggcaatcgtgcgcttccaga	13	11	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:5691004T>C	uc001iig.2	-	4	490	c.446A>G	c.(445-447)CAT>CGT	p.H149R	ASB13_uc001iii.2_RNA|ASB13_uc001iih.2_RNA|ASB13_uc009xic.2_Missense_Mutation_p.H149R	NM_024701	NP_078977	Q8WXK3	ASB13_HUMAN	ankyrin repeat and SOCS box-containing protein	149	ANK 5.				intracellular signal transduction		protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(2;9.59e-09)		GGTCCCAAAATGGCAATCGTG	0.542													0	0	0	0.003271	0	34	118										C	5691004	T	C	5691004	3	2	12	1	0	0	0	0	1	0	0	0	1017	1464	51	5	402	5	ASB13	10	5691004	Missense_Mutation	SNP	T	TCGA-BT-A20R-01A-12D-A16O-08		5691004	129843743	178	3017										
BMI1	648	broad.mit.edu	37	chr10	22616526	22616526	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	attttaattatttttcaggtCagataaaactctccaagata	4	6	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:22616526C>G	uc001irh.2	+	4	851	c.212C>G	c.(211-213)TCA>TGA	p.S71*	BMI1_uc009xkg.2_Nonsense_Mutation_p.S214*	NM_005180	NP_005171	P35226	BMI1_HUMAN	BMI1 polycomb ring finger oncogene	71					hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2						TTTTTCAGGTCAGATAAAACT	0.264													0	0	0	0.001855	0	13	121										G	22616526	C	G	22616526	4	3	12	1	0	0	0	0	0	1	0	0	1455	838	29	1	222	1	BMI1	10	22616526	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	16925522	22616526	112918221	179	3018										
NRP1	8829	broad.mit.edu	37	chr10	33619671	33619671	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccaaatcgaagtgagggttGaagttgatcataattctctg	10	6	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:33619671G>C	uc001iwx.3	-	2	736	c.213C>G	c.(211-213)TTC>TTG	p.F71L	NRP1_uc001iwv.3_Missense_Mutation_p.F71L|NRP1_uc009xlz.2_Missense_Mutation_p.F71L|NRP1_uc001iww.3_5'UTR|NRP1_uc001iwy.3_Missense_Mutation_p.F71L|NRP1_uc001iwz.2_Missense_Mutation_p.F71L|NRP1_uc001ixa.2_Missense_Mutation_p.F71L|NRP1_uc001ixb.1_Missense_Mutation_p.F71L|NRP1_uc001ixc.1_Missense_Mutation_p.F71L	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	71	CUB 1.|Extracellular (Potential).				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	AGTGAGGGTTGAAGTTGATCA	0.478													0	0	0	0.006214	0	10	44										C	33619671	G	C	33619671	3	2	12	1	0	0	0	0	1	0	0	0	10660	1281	45	1	2633	1	NRP1	10	33619671	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	11003145	33619671	101915076	180	3019										
SYT15	83849	broad.mit.edu	37	chr10	46967671	46967671	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtcggtctcacttttgtcctCcgggaacttgtacagctctg	10	12	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:46967671C>T	uc001jea.2	-	4	559	c.406G>A	c.(406-408)GAG>AAG	p.E136K	SYT15_uc001jdz.2_Missense_Mutation_p.E136K|SYT15_uc001jeb.2_Missense_Mutation_p.E14K|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	136	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						CTTTTGTCCTCCGGGAACTTG	0.617													0	0	0	0.00245	0	13	132										T	46967671	C	T	46967671	3	4	12	1	0	0	0	0	1	0	0	0	15468	864	30	1	933	1	SYT15	10	46967671	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	13348000	46967671	88567076	181	3020										
PCDH15	65217	broad.mit.edu	37	chr10	55581860	55581860	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatgccttttggttctctctGagggtctgttttacacactg	10	9	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:55581860G>C	uc001jju.1	-	33	6021	c.5626C>G	c.(5626-5628)CAG>GAG	p.Q1876E	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.Q730E|PCDH15_uc010qhv.1_Missense_Mutation_p.Q1873E|PCDH15_uc010qhw.1_Missense_Mutation_p.Q1836E|PCDH15_uc010qhx.1_Missense_Mutation_p.Q1807E|PCDH15_uc010qhy.1_Missense_Mutation_p.Q1883E|PCDH15_uc010qhz.1_Missense_Mutation_p.Q1878E|PCDH15_uc010qia.1_Missense_Mutation_p.Q1856E|PCDH15_uc010qib.1_Missense_Mutation_p.Q1853E	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1876	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GGTTCTCTCTGAGGGTCTGTT	0.388										HNSCC(58;0.16)			0	0	0	0.01441	0	58	67										C	55581860	G	C	55581860	3	2	12	1	0	0	0	0	1	0	0	0	11511	1299	45	1	1851	1	PCDH15	10	55581860	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8614189	55581860	79952887	182	3021										
ZWINT	11130	broad.mit.edu	37	chr10	58118398	58118398	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtcggctgctggggtttatcAtctggaagattctctgcctc	12	10	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:58118398A>T	uc001jjx.1	-	7	748	c.711T>A	c.(709-711)GAT>GAA	p.D237E	ZWINT_uc001jjy.1_Missense_Mutation_p.D190E|ZWINT_uc001jka.1_Missense_Mutation_p.D237E|ZWINT_uc009xoy.1_RNA	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	237					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						GGGGTTTATCATCTGGAAGAT	0.532													0	0	0	0.006122	0	18	27										T	58118398	A	T	58118398	3	4	12	1	0	0	0	0	1	0	0	0	18246	214	8	5	130	5	ZWINT	10	58118398	Missense_Mutation	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	2536538	58118398	77416349	183	3022										
NUDT13	25961	broad.mit.edu	37	chr10	74879774	74879774	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttgattatttcccaaatacAggtatttatttgaactgaag	6	5	0	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:74879774A>C	uc001jtj.2	+	3	209	c.84_splice	c.e3-2	p.R28_splice	NUDT13_uc010qkc.1_Splice_Site|NUDT13_uc010qkd.1_Splice_Site|NUDT13_uc009xqw.2_Splice_Site|NUDT13_uc001jtk.2_Splice_Site_p.R28_splice|NUDT13_uc010qke.1_Splice_Site|NUDT13_uc001jtl.2_Splice_Site_p.R28_splice	NM_015901	NP_056985	Q86X67	NUD13_HUMAN	nudix-type motif 13								hydrolase activity|metal ion binding				0	Prostate(51;0.0119)					TCCCAAATACAGGTATTTATT	0.408													0	0	0	0.000602	0	5	41										C	74879774	A	C	74879774	5	2	12	1	0	0	0	0	0	0	1	0	10729	202	7	5	88	5	NUDT13	10	74879774	Splice_Site	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	16761376	74879774	60654973	184	3023										
CYP26A1	1592	broad.mit.edu	37	chr10	94834560	94834560	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttatgcgggccttcagccgcGaggcactcgaatgctacgtg	13	12	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:94834560G>A	uc001kil.2	+	3	484	c.439G>A	c.(439-441)GAG>AAG	p.E147K	CYP26A1_uc001kik.1_Missense_Mutation_p.E78K|CYP26A1_uc001kim.1_Missense_Mutation_p.E45K	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	147					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				CTTCAGCCGCGAGGCACTCGA	0.657													0	0	0	0.010729	0	10	16										A	94834560	G	A	94834560	3	1	12	1	0	0	0	0	1	0	0	0	4155	1059	37	1	449	1	CYP26A1	10	94834560	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	19954786	94834560	40700187	185	3024										
EIF3A	8661	broad.mit.edu	37	chr10	120795652	120795652	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccatgaggccttctctttttCaccttctctttctcggtctc	5	15	5	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:120795652C>T	uc001ldu.2	-	22	4194	c.4048G>A	c.(4048-4050)GAA>AAA	p.E1350K	EIF3A_uc010qsu.1_Missense_Mutation_p.E1316K	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1350					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TTCTCTTTTTCACCTTCTCTT	0.507													0	0	0	0.00499	0	17	45										T	120795652	C	T	120795652	3	4	12	1	0	0	0	0	1	0	0	0	5012	835	29	1	104	1	EIF3A	10	120795652	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	25961092	120795652	14739095	186	3025										
TUBGCP2	10844	broad.mit.edu	37	chr10	135098627	135098627	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gagtgctgcttggcggttttGttgctgatccagacgctgca	14	9	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr10:135098627G>A	uc001lmg.1	-	13	2343	c.1986C>T	c.(1984-1986)AAC>AAT	p.N662N	TUBGCP2_uc001lmf.1_Silent_p.N255N|TUBGCP2_uc010qvc.1_Silent_p.N690N|TUBGCP2_uc009ybk.1_Silent_p.N685N|TUBGCP2_uc010qvd.1_Silent_p.N532N|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	662					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		TGGCGGTTTTGTTGCTGATCC	0.607													0	0	0	0.004482	0	9	52										A	135098627	G	A	135098627	2	1	12	1	0	0	0	0	0	0	0	1	16763	1368	48	2		2	TUBGCP2	10	135098627	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	14302975	135098627	436120	187	3026										
ANO9	338440	broad.mit.edu	37	chr11	431718	431718	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttcatcaactggctgctccCggaacatgtgtctccaccgc	8	15	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:431718C>T	uc001lpi.2	-	7	600	c.515G>A	c.(514-516)CGG>CAG	p.R172Q	ANO9_uc001lph.2_5'Flank|ANO9_uc010qvv.1_Missense_Mutation_p.R28Q	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	172	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TGGCTGCTCCCGGAACATGTG	0.667													0	0	0	0.000602	0	5	17										T	431718	C	T	431718	3	4	12	1	0	0	0	0	1	0	0	0	704	652	23	2	1901	2	ANO9	11	431718	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		431718	134574798	188	3027										
MOB2	81532	broad.mit.edu	37	chr11	1491480	1491480	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgcccccactgtggaccccGccggccccgctgcatagcac	10	21	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:1491480G>A	uc010qwz.1	-	5	919	c.729C>T	c.(727-729)GGC>GGT	p.G243G	MOB2_uc001lto.1_Silent_p.G127G|MOB2_uc001ltp.1_Missense_Mutation_p.R6W|MOB2_uc001ltq.1_Silent_p.G206G|MOB2_uc010qwy.1_Silent_p.G127G	NM_053005	NP_443731	Q70IA6	MOB2_HUMAN	HCCA2 protein	212						nucleus|perinuclear region of cytoplasm	metal ion binding				0						TGTGGACCCCGCCGGCCCCGC	0.682													0	0	0	0.008291	0	11	32										A	1491480	G	A	1491480	2	1	12	1	0	0	0	0	0	0	0	1	9681	1074	38	2		2	MOB2	11	1491480	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1059762	1491480	133515036	189	3028										
OR51F1	256892	broad.mit.edu	37	chr11	4790533	4790533	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tctattccagtggtcaggatGagatcaattaatccacagat	8	8	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:4790533G>A	uc010qyl.1	-	1	615	c.615C>T	c.(613-615)CTC>CTT	p.L205L		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	205						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		TGGTCAGGATGAGATCAATTA	0.413													0	0	0	0.008291	0	11	42										A	4790533	G	A	4790533	2	1	12	1	0	0	0	0	0	0	0	1	11096	1277	45	1		1	OR51F1	11	4790533	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3299053	4790533	130215983	190	3029										
FAM160A2	84067	broad.mit.edu	37	chr11	6232852	6232852	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatggcagccaactccttgaGaaattcagggaaaatgactg	11	8	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:6232852G>C	uc001mcl.3	-	12	3162	c.2803C>G	c.(2803-2805)CTC>GTC	p.L935V	FAM160A2_uc001mck.3_Missense_Mutation_p.L949V	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	935					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						AACTCCTTGAGAAATTCAGGG	0.557													0	0	0	0.014323	0	21	89										C	6232852	G	C	6232852	3	2	12	1	0	0	0	0	1	0	0	0	5469	942	33	1	119	1	FAM160A2	11	6232852	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1442319	6232852	128773664	191	3030										
APBB1	322	broad.mit.edu	37	chr11	6432324	6432324	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcacattgcgattctggtcaCggtgggccgtggcggcccgc	15	13	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:6432324C>T	uc001mdb.1	-	2	354	c.254G>A	c.(253-255)CGT>CAT	p.R85H	APBB1_uc001mdc.1_Missense_Mutation_p.R85H|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	85					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		ATTCTGGTCACGGTGGGCCGT	0.652													0	0	0	0.008361	0	29	135										T	6432324	C	T	6432324	3	4	12	1	0	0	0	0	1	0	0	0	759	536	19	2	1930	2	APBB1	11	6432324	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	199472	6432324	128574192	192	3031										
OR6A2	8590	broad.mit.edu	37	chr11	6816130	6816130	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttgttggtgtcaaaagctgaGagtgcctttggccgagcata	13	7	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:6816130G>C	uc001mes.1	-	1	1010	c.810C>G	c.(808-810)CTC>CTG	p.L270L		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAAAAGCTGAGAGTGCCTTTG	0.463													0	0	0	0.010729	0	12	67										C	6816130	G	C	6816130	2	2	12	1	0	0	0	0	0	0	0	1	11186	929	33	1		1	OR6A2	11	6816130	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	383806	6816130	128190386	193	3032										
FANCF	2188	broad.mit.edu	37	chr11	22647304	22647304	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgctgacgtaggtagtgcttGagaccgccagaagctcggaa	14	9	0	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:22647304G>C	uc001mql.1	-	1	84	c.53C>G	c.(52-54)TCA>TGA	p.S18*		NM_022725	NP_073562	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	18					DNA repair	nucleoplasm	protein binding			skin(1)	1						GGTAGTGCTTGAGACCGCCAG	0.637			N|F			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.001984	0	6	31										C	22647304	G	C	22647304	4	2	12	1	0	0	0	0	0	1	0	0	5667	1294	45	1	1075	1	FANCF	11	22647304	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	15831174	22647304	112359212	194	3033										
DDB2	1643	broad.mit.edu	37	chr11	47236784	47236784	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtcccctggagctggagcccGaggccaagaagctctgtgcg	15	13	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:47236784G>C	uc001neb.2	+	1	292	c.97G>C	c.(97-99)GAG>CAG	p.E33Q	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.E33Q|DDB2_uc001ned.2_RNA|DDB2_uc001nee.2_Missense_Mutation_p.E33Q|DDB2_uc001nef.2_5'UTR|DDB2_uc001neg.2_5'Flank|DDB2_uc001neh.2_5'Flank	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	33					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						GCTGGAGCCCGAGGCCAAGAA	0.612			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.004672	0	3	161										C	47236784	G	C	47236784	3	2	12	1	0	0	0	0	1	0	0	0	4324	1059	37	1	99	1	DDB2	11	47236784	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	24589480	47236784	87769732	195	3034										
C11orf48	79081	broad.mit.edu	37	chr11	62435136	62435136	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagaatccaacaagcatcttCttcatcctggtcctgccccc	5	16	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:62435136C>G	uc001nue.2	-	4	832	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	C11orf48_uc001nuf.2_Missense_Mutation_p.E133Q|METTL12_uc001nuh.2_3'UTR|C11orf48_uc010rmd.1_Missense_Mutation_p.E133Q	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	hypothetical protein LOC79081	159											0						CAAGCATCTTCTTCATCCTGG	0.537													0	0	0	0.00245	0	14	315										G	62435136	C	G	62435136	3	3	12	1	0	0	0	0	1	0	0	0	1644	922	32	1	410	1	C11orf48	11	62435136	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	15198352	62435136	72571380	196	3035										
ZBTB3	79842	broad.mit.edu	37	chr11	62521497	62521497	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gctcccaggccttgccaggcGatgcctctacgccccacttc	9	19	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:62521497G>A	uc001nuz.2	-	1	160	c.38C>T	c.(37-39)TCG>TTG	p.S13L		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						CTTGCCAGGCGATGCCTCTAC	0.597													0	0	0	0.008291	0	9	56										A	62521497	G	A	62521497	3	1	12	1	0	0	0	0	1	0	0	0	17531	1059	37	1	1694	1	ZBTB3	11	62521497	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	86361	62521497	72485019	197	3036										
SLC22A12	116085	broad.mit.edu	37	chr11	64359356	64359356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccacggccaccagctggagcGaggccgacacggagccgtgt	15	15	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:64359356G>A	uc001oam.1	+	1	1075	c.328G>A	c.(328-330)GAG>AAG	p.E110K	SLC22A12_uc009ypr.1_Missense_Mutation_p.E110K|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.E110K|SLC22A12_uc001oan.1_Missense_Mutation_p.E110K|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	110					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CAGCTGGAGCGAGGCCGACAC	0.677													0	0	0	0.001168	0	6	37										A	64359356	G	A	64359356	3	1	12	1	0	0	0	0	1	0	0	0	14443	1059	37	1	330	1	SLC22A12	11	64359356	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1837859	64359356	70647160	198	3037										
POLA2	23649	broad.mit.edu	37	chr11	65055264	65055264	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcacgtatgaccccctgcttGacctgattgctgtcatcaac	7	14	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:65055264G>A	uc001odj.2	+	11	1426	c.1084G>A	c.(1084-1086)GAC>AAC	p.D362N	POLA2_uc010rod.1_Missense_Mutation_p.D154N|POLA2_uc001odk.2_Missense_Mutation_p.D59N	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	362					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	CCCCCTGCTTGACCTGATTGC	0.502													0	0	0	0.000602	0	5	74										A	65055264	G	A	65055264	3	1	12	1	0	0	0	0	1	0	0	0	12188	1290	45	1	1126	1	POLA2	11	65055264	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	695908	65055264	69951252	199	3038										
POLA2	23649	broad.mit.edu	37	chr11	65063047	65063047	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gacagattcagccgaatactCaagcacatcttgacccagag	8	12	3	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:65063047C>G	uc001odj.2	+	16	1839	c.1497C>G	c.(1495-1497)CTC>CTG	p.L499L	POLA2_uc010rod.1_Silent_p.L291L|POLA2_uc001odk.2_Silent_p.L196L	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	499					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	GCCGAATACTCAAGCACATCT	0.498													0	0	0	0.010729	0	10	130										G	65063047	C	G	65063047	2	3	12	1	0	0	0	0	0	0	0	1	12188	813	29	1		1	POLA2	11	65063047	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	7783	65063047	69943469	200	3039										
FRMD8	83786	broad.mit.edu	37	chr11	65168229	65168229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cctgcgcttccaggagctgtCgtgggaccacacctcccccg	11	18	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:65168229C>T	uc001odu.3	+	9	1154	c.962C>T	c.(961-963)TCG>TTG	p.S321L	FRMD8_uc009yqj.2_Missense_Mutation_p.S265L|FRMD8_uc010rof.1_Missense_Mutation_p.S287L	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	321	FERM.					cytoskeleton	binding	p.S321S(1)		lung(1)|pancreas(1)	2						CAGGAGCTGTCGTGGGACCAC	0.647													0	0	0	0.00308	0	8	44										T	65168229	C	T	65168229	3	4	12	1	0	0	0	0	1	0	0	0	6056	893	31	1	992	1	FRMD8	11	65168229	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	105182	65168229	69838287	201	3040										
RIN1	9610	broad.mit.edu	37	chr11	66100213	66100213	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgggatcctgataggctactCggaggaggtgctatgcagga	16	7	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:66100213C>T	uc001ohn.1	-	10	2013	c.1886G>A	c.(1885-1887)CGA>CAA	p.R629Q	RIN1_uc010roy.1_Missense_Mutation_p.R260Q|RIN1_uc009yrd.1_Missense_Mutation_p.R322Q|RIN1_uc010roz.1_Missense_Mutation_p.R524Q|RIN1_uc010rpa.1_Missense_Mutation_p.R463Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	629	Ras and 14-3-3 protein binding region.|Ras-associating.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						ATAGGCTACTCGGAGGAGGTG	0.592													0	0	0	0.008291	0	11	84										T	66100213	C	T	66100213	3	4	12	1	0	0	0	0	1	0	0	0	13371	884	31	1	469	1	RIN1	11	66100213	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	931984	66100213	68906303	202	3041										
INPPL1	3636	broad.mit.edu	37	chr11	71946359	71946359	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggggagtgtgtggttgcactCaaatccatgatcggcagcac	14	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:71946359C>G	uc001osf.2	+	23	2670	c.2523C>G	c.(2521-2523)CTC>CTG	p.L841L	INPPL1_uc001osg.2_Silent_p.L599L	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	841					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						TGGTTGCACTCAAATCCATGA	0.572													0	0	0	0.008871	0	20	99										G	71946359	C	G	71946359	2	3	12	1	0	0	0	0	0	0	0	1	7761	813	29	1		1	INPPL1	11	71946359	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5846146	71946359	63060157	203	3042										
INPPL1	3636	broad.mit.edu	37	chr11	71949157	71949157	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agtgcctggctgcgggccatCggcttggagcgctatgagga	17	10	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:71949157C>G	uc001osf.2	+	27	3771	c.3624C>G	c.(3622-3624)ATC>ATG	p.I1208M	INPPL1_uc001osg.2_Missense_Mutation_p.I966M	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1208	SAM.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						TGCGGGCCATCGGCTTGGAGC	0.711											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	21										G	71949157	C	G	71949157	3	3	12	1	0	0	0	0	1	0	0	0	7761	874	31	1	3730	1	INPPL1	11	71949157	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2798	71949157	63057359	204	3043										
STARD10	10809	broad.mit.edu	37	chr11	72469670	72469670	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acggttcttcaggggcttggGacacctccctgtggggggca	16	11	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:72469670G>C	uc001osy.2	-	4	655	c.364C>G	c.(364-366)CCC>GCC	p.P122A	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Missense_Mutation_p.P122A|STARD10_uc001ota.2_Missense_Mutation_p.P76A|STARD10_uc001otb.2_Missense_Mutation_p.P122A	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	122	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			AGGGGCTTGGGACACCTCCCT	0.582													0	0	0	0.004672	0	3	19										C	72469670	G	C	72469670	3	2	12	1	0	0	0	0	1	0	0	0	15254	1174	41	1	527	1	STARD10	11	72469670	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	520513	72469670	62536846	205	3044										
C11orf30	56946	broad.mit.edu	37	chr11	76257114	76257114	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccactagcatgctcactggtGaagcaggatcattaccctcc	8	14	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:76257114G>A	uc001oxl.2	+	20	3690	c.3547G>A	c.(3547-3549)GAA>AAA	p.E1183K	C11orf30_uc001oxm.2_Missense_Mutation_p.E1085K|C11orf30_uc010rsb.1_Missense_Mutation_p.E1198K|C11orf30_uc010rsc.1_Missense_Mutation_p.E1184K|C11orf30_uc001oxn.2_Missense_Mutation_p.E1184K|C11orf30_uc010rsd.1_Missense_Mutation_p.E1092K|C11orf30_uc010rse.1_Missense_Mutation_p.E430K|C11orf30_uc001oxp.2_Intron	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1183					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GCTCACTGGTGAAGCAGGATC	0.478													0	0	0	0.003163	0	14	46										A	76257114	G	A	76257114	3	1	12	1	0	0	0	0	1	0	0	0	1636	1291	45	1	3621	1	C11orf30	11	76257114	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3787444	76257114	58749402	206	3045										
FAT3	120114	broad.mit.edu	37	chr11	92523337	92523337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctggcgtgctctatactgccGagaggctggaccatgaggcc	14	12	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:92523337G>A	uc001pdj.3	+	7	4581	c.4564G>A	c.(4564-4566)GAG>AAG	p.E1522K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1522	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTATACTGCCGAGAGGCTGGA	0.498										TCGA Ovarian(4;0.039)			0	0	0	0.008871	0	21	117										A	92523337	G	A	92523337	3	1	12	1	0	0	0	0	1	0	0	0	5691	1059	37	1	4590	1	FAT3	11	92523337	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	16266223	92523337	42483179	207	3046										
KIAA1377	57562	broad.mit.edu	37	chr11	101849120	101849120	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acgaattgctgaaactaagcGgagaaatattttagagcaga	10	5	0	4	rs150274963	byFrequency	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr11:101849120G>A	uc001pgm.2	+	7	3158	c.2888G>A	c.(2887-2889)CGG>CAG	p.R963Q	KIAA1377_uc001pgn.2_Missense_Mutation_p.R919Q|KIAA1377_uc010run.1_Missense_Mutation_p.R764Q	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	963							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAAACTAAGCGGAGAAATATT	0.333													0	0	0	0.000602	0	5	180										A	101849120	G	A	101849120	3	1	12	1	0	0	0	0	1	0	0	0	8227	1116	39	2	2914	2	KIAA1377	11	101849120	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	9325783	101849120	33157396	208	3047										
CACNA1C	775	broad.mit.edu	37	chr12	2797760	2797760	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccctgcggcttgagggggtcGagtccagtgagaaactcaac	14	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:2797760G>A	uc009zdu.1	+	49	6494	c.6181G>A	c.(6181-6183)GAG>AAG	p.E2061K	CACNA1C_uc009zdv.1_Missense_Mutation_p.E1975K|CACNA1C_uc001qkb.2_Missense_Mutation_p.E1978K|CACNA1C_uc001qkc.2_Missense_Mutation_p.E1997K|CACNA1C_uc001qke.2_Missense_Mutation_p.E1967K|CACNA1C_uc001qkf.2_Missense_Mutation_p.E1986K|CACNA1C_uc001qjz.2_Missense_Mutation_p.E1978K|CACNA1C_uc001qkd.2_Missense_Mutation_p.E1997K|CACNA1C_uc001qkg.2_Missense_Mutation_p.E1984K|CACNA1C_uc009zdw.1_Missense_Mutation_p.E2019K|CACNA1C_uc001qkh.2_Missense_Mutation_p.E1986K|CACNA1C_uc001qkl.2_Missense_Mutation_p.E2026K|CACNA1C_uc001qkn.2_Missense_Mutation_p.E1978K|CACNA1C_uc001qko.2_Missense_Mutation_p.E1998K|CACNA1C_uc001qkp.2_Missense_Mutation_p.E1978K|CACNA1C_uc001qkr.2_Missense_Mutation_p.E1995K|CACNA1C_uc001qku.2_Missense_Mutation_p.E2013K|CACNA1C_uc001qkq.2_Missense_Mutation_p.E2006K|CACNA1C_uc001qks.2_Missense_Mutation_p.E1978K|CACNA1C_uc001qkt.2_Missense_Mutation_p.E1997K|CACNA1C_uc001qki.1_Missense_Mutation_p.E1785K|CACNA1C_uc001qkj.1_Missense_Mutation_p.E1749K|CACNA1C_uc001qkk.1_Missense_Mutation_p.E1714K|CACNA1C_uc001qkm.1_Missense_Mutation_p.E1774K|CACNA1C_uc010sea.1_Missense_Mutation_p.E669K|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.E296K	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2061	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGAGGGGGTCGAGTCCAGTGA	0.692													0	0	0	0.013537	0	13	53										A	2797760	G	A	2797760	3	1	12	1	0	0	0	0	1	0	0	0	2540	1059	37	1	6823	1	CACNA1C	12	2797760	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		2797760	131054135	209	3048										
FGF6	2251	broad.mit.edu	37	chr12	4553375	4553375	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caaagagactcaccacgcctCgctccacagtggaaatttcc	7	15	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:4553375C>T	uc001qmr.1	-	2	418	c.374G>A	c.(373-375)CGA>CAA	p.R125Q		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	125					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			CACCACGCCTCGCTCCACAGT	0.537													0	0	0	0.010729	0	9	36										T	4553375	C	T	4553375	3	4	12	1	0	0	0	0	1	0	0	0	5856	884	31	1	260	1	FGF6	12	4553375	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1755615	4553375	129298520	210	3049										
PZP	5858	broad.mit.edu	37	chr12	9353646	9353646	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gccattgtgcaattcgatttCttcttgggttctgaagggaa	11	7	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:9353646C>G	uc001qvl.2	-	6	541	c.512G>C	c.(511-513)AGA>ACA	p.R171T	PZP_uc009zgl.2_Missense_Mutation_p.R40T	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AATTCGATTTCTTCTTGGGTT	0.438													0	0	0	0.003163	0	13	60										G	9353646	C	G	9353646	3	3	12	1	0	0	0	0	1	0	0	0	12869	913	32	1	4060	1	PZP	12	9353646	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4800271	9353646	124498249	211	3050										
PPFIBP1	8496	broad.mit.edu	37	chr12	27844717	27844717	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttagcaattttgggaatttGagaaagaagaaacaggaaga	11	2	0	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:27844717G>A	uc001ric.1	+	27	3116	c.2739G>A	c.(2737-2739)TTG>TTA	p.L913L	PPFIBP1_uc010sjr.1_Silent_p.L744L|PPFIBP1_uc001rib.1_Silent_p.L907L|PPFIBP1_uc001ria.2_Silent_p.L882L|PPFIBP1_uc001rid.1_Silent_p.L760L|PPFIBP1_uc001rif.1_Silent_p.L420L	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	913					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					TTGGGAATTTGAGAAAGAAGA	0.353													0	0	0	0.013537	0	12	63										A	27844717	G	A	27844717	2	1	12	1	0	0	0	0	0	0	0	1	12313	1281	45	1		1	PPFIBP1	12	27844717	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	18491071	27844717	106007178	212	3051										
PDZRN4	29951	broad.mit.edu	37	chr12	41587902	41587902	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaataatcaggaaggaacatCgactgaaggaatttacgttt	10	5	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:41587902C>T	uc010skn.1	+	3	226	c.158C>T	c.(157-159)TCG>TTG	p.S53L		NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	252	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAGGAACATCGACTGAAGGA	0.318													0	0	0	0.009096	0	4	29										T	41587902	C	T	41587902	3	4	12	1	0	0	0	0	1	0	0	0	11710	893	31	1	765	1	PDZRN4	12	41587902	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	13743185	41587902	92263993	213	3052										
DAZAP2	9802	broad.mit.edu	37	chr12	51636147	51636147	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatgccctcccaatgctgctCagcttgcagtcatgcaggga	11	13	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:51636147C>G	uc010snd.1	+	4	519	c.335C>G	c.(334-336)TCA>TGA	p.S112*	DAZAP2_uc001ryb.2_Missense_Mutation_p.Q116E|DAZAP2_uc010snc.1_Missense_Mutation_p.Q56E|DAZAP2_uc010sne.1_Missense_Mutation_p.Q106E|DAZAP2_uc010snf.1_Intron	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	Error:Variant_position_missing_in_Q15038_after_alignment							WW domain binding				0						CAATGCTGCTCAGCTTGCAGT	0.537													0	0	0	0.001984	0	7	333										G	51636147	C	G	51636147	4	3	12	1	0	0	0	0	0	1	0	0	4245	839	29	1	426	1	DAZAP2	12	51636147	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	10048245	51636147	82215748	214	3053										
ERBB3	2065	broad.mit.edu	37	chr12	56478817	56478817	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggctatgtcctcgtggccatGaatgaattctctactctacc	8	12	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:56478817G>C	uc001sjh.2	+	3	466	c.273G>C	c.(271-273)ATG>ATC	p.M91I	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.M32I|ERBB3_uc001sjg.2_Missense_Mutation_p.M91I	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	91	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TCGTGGCCATGAATGAATTCT	0.473													0	0	0	0.012213	0	33	83										C	56478817	G	C	56478817	3	2	12	1	0	0	0	0	1	0	0	0	5208	1290	45	1	283	1	ERBB3	12	56478817	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4842670	56478817	77373078	215	3054										
ESYT1	23344	broad.mit.edu	37	chr12	56531825	56531825	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aacaggtgtaaagtgcgtctCaccacagtcttaaacagtgg	10	9	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:56531825C>A	uc001sjq.2	+	20	2264	c.2214C>A	c.(2212-2214)CTC>CTA	p.L738L	ESYT1_uc001sjr.2_Silent_p.L748L	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	738				L -> F (in Ref. 2; BAB15139).		integral to membrane				ovary(4)|skin(1)	5						AAGTGCGTCTCACCACAGTCT	0.473													1	0	2.51541e-25	0.004878	2.76314e-25	36	93										A	56531825	C	A	56531825	2	1	12	1	0	0	0	0	0	0	0	1	5264	813	29	3		3	ESYT1	12	56531825	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	53008	56531825	77320070	216	3055										
LRP1	4035	broad.mit.edu	37	chr12	57556275	57556275	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gccccccatctttgagatccGaatgtatgatgcccagcagc	9	14	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:57556275G>A	uc001snd.2	+	14	2844	c.2378G>A	c.(2377-2379)CGA>CAA	p.R793Q		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	793	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity	p.R793*(1)		ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TTTGAGATCCGAATGTATGAT	0.607													0	0	0	0.001984	0	7	77										A	57556275	G	A	57556275	3	1	12	1	0	0	0	0	1	0	0	0	8951	1058	37	1	2432	1	LRP1	12	57556275	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1024450	57556275	76295620	217	3056										
PTPRB	5787	broad.mit.edu	37	chr12	70970178	70970178	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttacctgtccgctcttggctGaaggagtgattttcatactt	9	9	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:70970178G>A	uc001swb.3	-	9	2202	c.2172C>T	c.(2170-2172)TTC>TTT	p.F724F	PTPRB_uc010sto.1_Silent_p.F724F|PTPRB_uc010stp.1_Silent_p.F634F|PTPRB_uc001swc.3_Silent_p.F942F|PTPRB_uc001swa.3_Intron|PTPRB_uc001swd.3_Silent_p.F941F|PTPRB_uc009zrr.1_Silent_p.F821F	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	724	Fibronectin type-III 8.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTCTTGGCTGAAGGAGTGAT	0.512													0	0	0	0.000602	0	4	20										A	70970178	G	A	70970178	2	1	12	1	0	0	0	0	0	0	0	1	12796	1281	45	1		1	PTPRB	12	70970178	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13413903	70970178	62881717	218	3057										
NAP1L1	4673	broad.mit.edu	37	chr12	76447602	76447602	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agaaaagggatcagaatcatCtggttctgacctcatcctgt	9	9	5	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:76447602C>G	uc001sxw.2	-	9	1130	c.718G>C	c.(718-720)GAT>CAT	p.D240H	NAP1L1_uc001sxv.2_Missense_Mutation_p.D198H|NAP1L1_uc001sxz.2_Missense_Mutation_p.D171H|NAP1L1_uc001sxx.2_Missense_Mutation_p.D240H|NAP1L1_uc001sxy.2_Missense_Mutation_p.D177H|NAP1L1_uc010sty.1_Missense_Mutation_p.D197H|NAP1L1_uc010stz.1_Missense_Mutation_p.D57H|NAP1L1_uc010sua.1_Missense_Mutation_p.D240H|NAP1L1_uc001syb.2_Missense_Mutation_p.D240H|NAP1L1_uc001sya.2_Missense_Mutation_p.D198H|NAP1L1_uc001syc.2_Missense_Mutation_p.D251H	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	240					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				TCAGAATCATCTGGTTCTGAC	0.348													0	0	0	0.00499	0	17	33										G	76447602	C	G	76447602	3	3	12	1	0	0	0	0	1	0	0	0	10156	913	32	1	485	1	NAP1L1	12	76447602	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5477424	76447602	57404293	219	3058										
NTN4	59277	broad.mit.edu	37	chr12	96104265	96104265	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggtctccgcaggtcacgataGaagcctggcttgcacctctg	12	13	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:96104265G>C	uc001tei.2	-	5	1583	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	NTN4_uc009ztf.2_Missense_Mutation_p.F378L|NTN4_uc009ztg.2_Missense_Mutation_p.F341L	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	378	Laminin EGF-like 2.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GGTCACGATAGAAGCCTGGCT	0.483													0	0	0	0.013537	0	13	52										C	96104265	G	C	96104265	3	2	12	1	0	0	0	0	1	0	0	0	10702	933	33	1	776	1	NTN4	12	96104265	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	19656663	96104265	37747630	220	3059										
UTP20	27340	broad.mit.edu	37	chr12	101686964	101686964	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agatatttgagagcagatttGaaaaacgtttaattttcagt	8	3	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:101686964G>A	uc001tia.1	+	11	1348	c.1192G>A	c.(1192-1194)GAA>AAA	p.E398K		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	398					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GAGCAGATTTGAAAAACGTTT	0.353													0	0	0	0.00245	0	15	39										A	101686964	G	A	101686964	3	1	12	1	0	0	0	0	1	0	0	0	17096	1291	45	1	1234	1	UTP20	12	101686964	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	5582699	101686964	32164931	221	3060										
CCDC53	51019	broad.mit.edu	37	chr12	102455053	102455053	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caaactgtagaaaagcggttGaggaactgtacagtgtgcac	12	7	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:102455053G>A	uc010svw.1	-	2	282	c.123C>T	c.(121-123)CTC>CTT	p.L41L	CCDC53_uc010svx.1_RNA|CCDC53_uc010svy.1_RNA|CCDC53_uc010svz.1_Silent_p.L41L	NM_016053	NP_057137	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	41						WASH complex	protein binding				0						AAAAGCGGTTGAGGAACTGTA	0.438													0	0	0	0.00245	0	11	34										A	102455053	G	A	102455053	2	1	12	1	0	0	0	0	0	0	0	1	2823	1277	45	1		1	CCDC53	12	102455053	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	768089	102455053	31396842	222	3061										
STAB2	55576	broad.mit.edu	37	chr12	104071314	104071314	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aatgggagagactgctcggaGatcaacaactgcctgctgcc	12	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:104071314G>C	uc001tjw.2	+	25	2916	c.2730G>C	c.(2728-2730)GAG>GAC	p.E910D		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	910	Extracellular (Potential).|EGF-like 9.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ACTGCTCGGAGATCAACAACT	0.572													0	0	0	0.013726	0	33	89										C	104071314	G	C	104071314	3	2	12	1	0	0	0	0	1	0	0	0	15237	933	33	1	2828	1	STAB2	12	104071314	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1616261	104071314	29780581	223	3062										
MORN3	283385	broad.mit.edu	37	chr12	122091125	122091125	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaacgccccgccccgttcttCatgcctctctcccagcagcc	6	21	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:122091125C>T	uc001uax.2	-	4	675	c.504G>A	c.(502-504)ATG>ATA	p.M168I	MORN3_uc001uay.2_Intron	NM_173855	NP_776254	Q6PF18	MORN3_HUMAN	MORN repeat containing 3	168	MORN 6.										0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)		CCCCGTTCTTCATGCCTCTCT	0.587													0	0	0	0.006214	0	9	44										T	122091125	C	T	122091125	3	4	12	1	0	0	0	0	1	0	0	0	9709	826	29	1	226	1	MORN3	12	122091125	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	18019811	122091125	11760770	224	3063										
ZCCHC8	55596	broad.mit.edu	37	chr12	122958340	122958340	+	Frame_Shift_Del	DEL	C	C	-													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cggagccaactctgctttttCcttctgacaaagtgatgtca							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:122958340delC	uc001ucn.2	-	14	1959	c.1828delG	c.(1828-1830)GAAfs	p.E610fs	ZCCHC8_uc001ucl.2_Frame_Shift_Del_p.E221fs|ZCCHC8_uc001ucm.2_Frame_Shift_Del_p.E372fs|ZCCHC8_uc009zxp.2_Frame_Shift_Del_p.E372fs|ZCCHC8_uc009zxq.2_Frame_Shift_Del_p.E372fs	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	610						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TCTGCTTTTTCCTTCTGACAA	0.493																		7	262	---	---								-	122958340	C	-	122958340	7	5	12	1	0	1	0	1	0	0	0	0	17591	864	30	0	299	0	ZCCHC8	12	122958340	Frame_Shift_Del	DEL	C	TCGA-BT-A20R-01A-12D-A16O-08	867215	122958340	10893555	225	3064										
GPR109A	338442	broad.mit.edu	37	chr12	123187019	123187019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	taaagaacgccaggtccaccGagcggtacacttcacaattc	8	13	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr12:123187019G>A	uc001ucx.1	-	1	886	c.812C>T	c.(811-813)TCG>TTG	p.S271L	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	271	Extracellular (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	CAGGTCCACCGAGCGGTACAC	0.542													0	0	0	0.000602	0	5	52										A	123187019	G	A	123187019	3	1	12	1	0	0	0	0	1	0	0	0	6625	1059	37	1	283	1	GPR109A	12	123187019	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	228679	123187019	10664876	226	3065										
RNF17	56163	broad.mit.edu	37	chr13	25428222	25428222	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcctaacatgaacgtatttGaggcaacagtcagctgtgtt	9	8	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:25428222G>C	uc001upr.2	+	25	3591	c.3550G>C	c.(3550-3552)GAG>CAG	p.E1184Q	RNF17_uc010tdd.1_Missense_Mutation_p.E1043Q|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.E1180Q|RNF17_uc001ups.2_Missense_Mutation_p.E1123Q|RNF17_uc010aac.2_Missense_Mutation_p.E382Q|RNF17_uc010aad.2_Missense_Mutation_p.E236Q	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1184					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GAACGTATTTGAGGCAACAGT	0.393													0	0	0	0.001984	0	7	38										C	25428222	G	C	25428222	3	2	12	1	0	0	0	0	1	0	0	0	13461	1291	45	1	3648	1	RNF17	13	25428222	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		25428222	89741656	227	3066										
RB1	5925	broad.mit.edu	37	chr13	48881462	48881462	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgattttactgcattatgtCagaaattaaagataccagat	6	6	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:48881462C>T	uc001vcb.2	+	2	350	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	62					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(13)|p.?(3)|p.Q62*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGCATTATGTCAGAAATTAAA	0.323		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.001168	0	6	26										T	48881462	C	T	48881462	4	4	12	1	0	0	0	0	0	1	0	0	13098	827	29	1	190	1	RB1	13	48881462	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	23453240	48881462	66288416	228	3067										
RNF219	79596	broad.mit.edu	37	chr13	79219061	79219061	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	caagctggacactggctattAttcttcaaccacaaatcaat	5	11	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:79219061A>G	uc001vkw.1	-	2	203	c.144T>C	c.(142-144)AAT>AAC	p.N48N	RNF219_uc010afb.1_5'UTR|RNF219_uc010afc.2_Silent_p.N48N	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	48	RING-type; degenerate.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		ACTGGCTATTATTCTTCAACC	0.368													0	0	0	0.008871	0	20	66										G	79219061	A	G	79219061	2	3	12	1	0	0	0	0	0	0	0	1	13482	446	16	5		5	RNF219	13	79219061	Silent	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	30337599	79219061	35950817	229	3068										
RBM26	64062	broad.mit.edu	37	chr13	79939829	79939829	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttatgcttggggcttcaggaTtgtagccatctgtgtcatat	11	7	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:79939829T>C	uc001vkz.2	-	9	1330	c.1316A>G	c.(1315-1317)AAT>AGT	p.N439S	RBM26_uc001vky.2_Missense_Mutation_p.N434S|RBM26_uc001vla.2_Missense_Mutation_p.N434S|RBM26_uc001vkx.2_Missense_Mutation_p.N146S	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	434					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GGCTTCAGGATTGTAGCCATC	0.353													0	0	0	0.00308	0	7	62										C	79939829	T	C	79939829	3	2	12	1	0	0	0	0	1	0	0	0	13126	1493	52	5	1693	5	RBM26	13	79939829	Missense_Mutation	SNP	T	TCGA-BT-A20R-01A-12D-A16O-08	720768	79939829	35230049	230	3069										
KDELC1	79070	broad.mit.edu	37	chr13	103450976	103450976	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccggtctcggcgagtgctggAactgtcgccagaaagaagca	14	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr13:103450976A>C	uc001vpq.3	-	1	429	c.45T>G	c.(43-45)GTT>GTG	p.V15V	KDELC1_uc001vpr.3_5'UTR|BIVM_uc001vps.2_5'Flank|BIVM_uc010agc.2_5'Flank	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	15						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CGAGTGCTGGAACTGTCGCCA	0.532													0	0	0	0.013537	0	12	43										C	103450976	A	C	103450976	2	2	12	1	0	0	0	0	0	0	0	1	8117	233	9	5		5	KDELC1	13	103450976	Silent	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	23511147	103450976	11718902	231	3070										
OR4L1	122742	broad.mit.edu	37	chr14	20528789	20528789	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gcattgaaacatacaccctgGaattatttgtcattgctgac	7	9	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:20528789G>A	uc001vwn.1	+	1	586	c.586G>A	c.(586-588)GAA>AAA	p.E196K		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATACACCCTGGAATTATTTGT	0.408													0	0	0	0.01441	0	59	80										A	20528789	G	A	20528789	3	1	12	1	0	0	0	0	1	0	0	0	11074	1175	41	1	588	1	OR4L1	14	20528789	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		20528789	86820751	232	3071										
MRPL52	122704	broad.mit.edu	37	chr14	23299420	23299420	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggactggctgccaacccctcCggctacgggccccttaccga	11	18	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:23299420C>T	uc001wgw.3	+	3	144	c.114C>T	c.(112-114)TCC>TCT	p.S38S	MRPL52_uc001wgx.3_Silent_p.S37S|MRPL52_uc001wgy.3_5'UTR|MRPL52_uc001wgz.3_5'UTR|MRPL52_uc001wha.3_5'UTR|MRPL52_uc001whb.3_Silent_p.S38S	NM_178336	NP_848026	Q86TS9	RM52_HUMAN	mitochondrial ribosomal protein L52 isoform a	38					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		CCAACCCCTCCGGCTACGGGC	0.597													0	0	0	0.007291	0	27	94										T	23299420	C	T	23299420	2	4	12	1	0	0	0	0	0	0	0	1	9816	639	23	2		2	MRPL52	14	23299420	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2770631	23299420	84050120	233	3072										
ZFYVE26	23503	broad.mit.edu	37	chr14	68265271	68265271	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttccagaagctccaggcacaGagagtcaggaatactgcaca	10	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:68265271G>C	uc001xka.2	-	11	1847	c.1708C>G	c.(1708-1710)CTG>GTG	p.L570V	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.L570V|ZFYVE26_uc010tta.1_Missense_Mutation_p.L570V	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	570					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCCAGGCACAGAGAGTCAGGA	0.478													0	0	0	0.000602	0	5	47										C	68265271	G	C	68265271	3	2	12	1	0	0	0	0	1	0	0	0	17665	933	33	1	6039	1	ZFYVE26	14	68265271	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	44965851	68265271	39084269	234	3073										
ZFYVE26	23503	broad.mit.edu	37	chr14	68273295	68273295	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggaagtgtttgttgttgctCaggcagtagaaataggccac	13	6	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:68273295C>G	uc001xka.2	-	6	1123	c.984G>C	c.(982-984)CTG>CTC	p.L328L	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.L328L|ZFYVE26_uc010tta.1_Silent_p.L328L	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	328					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGTTGTTGCTCAGGCAGTAGA	0.498													0	0	0	0.001984	0	7	34										G	68273295	C	G	68273295	2	3	12	1	0	0	0	0	0	0	0	1	17665	813	29	1		1	ZFYVE26	14	68273295	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	8024	68273295	39076245	235	3074										
ZFP36L1	677	broad.mit.edu	37	chr14	69257106	69257106	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggagctgggcagggtgactGagtgcctccgagggaagccc	18	10	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:69257106G>C	uc001xkh.1	-	2	291	c.161C>G	c.(160-162)TCA>TGA	p.S54*	ZFP36L1_uc001xki.1_Nonsense_Mutation_p.S54*	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	54					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CAGGGTGACTGAGTGCCTCCG	0.632											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	11	22										C	69257106	G	C	69257106	4	2	12	1	0	0	0	0	0	1	0	0	17643	1294	45	1	859	1	ZFP36L1	14	69257106	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	983811	69257106	38092434	236	3075										
TTC9	23508	broad.mit.edu	37	chr14	71137855	71137855	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcagccgatgctcccagagaGaaaaagaagccatgtaacca	9	11	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:71137855G>C	uc001xmi.2	+	3	995	c.652G>C	c.(652-654)GAA>CAA	p.E218Q		NM_015351	NP_056166	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	218							binding				0				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		CTCCCAGAGAGAAAAAGAAGC	0.557													0	0	0	0.001984	0	7	28										C	71137855	G	C	71137855	3	2	12	1	0	0	0	0	1	0	0	0	16712	943	33	1	662	1	TTC9	14	71137855	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1880749	71137855	36211685	237	3076										
PTPN21	11099	broad.mit.edu	37	chr14	88945434	88945434	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccagggccgctgggcctctgCggtcgtgcggacggggctgc	19	14	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:88945434C>T	uc001xwv.3	-	13	2672	c.2341G>A	c.(2341-2343)GCA>ACA	p.A781T	PTPN21_uc010twc.1_Missense_Mutation_p.A577T	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	781						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TGGGCCTCTGCGGTCGTGCGG	0.697													0	0	0	0.001984	0	7	45										T	88945434	C	T	88945434	3	4	12	1	0	0	0	0	1	0	0	0	12786	768	27	2	1211	2	PTPN21	14	88945434	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	17807579	88945434	18404106	238	3077										
TDP1	55775	broad.mit.edu	37	chr14	90442142	90442142	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	taggcaaagttggatattgcGtttggaacacaccacacgta	10	8	0	0	rs139270583	byFrequency	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:90442142G>A	uc001xxy.2	+	7	1073	c.774G>A	c.(772-774)GCG>GCA	p.A258A	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Silent_p.A258A|TDP1_uc010atn.2_Silent_p.A258A|TDP1_uc001xya.2_Intron|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Silent_p.A258A	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	258					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TGGATATTGCGTTTGGAACAC	0.373								Repair_of_DNA-protein_crosslinks					0	0	0	0.006122	0	18	98										A	90442142	G	A	90442142	2	1	12	1	0	0	0	0	0	0	0	1	15725	1132	40	2		2	TDP1	14	90442142	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1496708	90442142	16907398	239	3078										
C14orf68	283600	broad.mit.edu	37	chr14	100795778	100795778	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gccacccccatggacgtgatCaagtcgagactgcaggcaga	12	13	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:100795778C>G	uc001yhc.2	+	6	796	c.723C>G	c.(721-723)ATC>ATG	p.I241M	C14orf68_uc001yhd.2_Missense_Mutation_p.I95M	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	241	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				TGGACGTGATCAAGTCGAGAC	0.667													0	0	0	0.004482	0	9	58										G	100795778	C	G	100795778	3	3	12	1	0	0	0	0	1	0	0	0	1778	816	29	1	745	1	C14orf68	14	100795778	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	10353636	100795778	6553762	240	3079										
BRF1	2972	broad.mit.edu	37	chr14	105688029	105688029	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgcattcgcggatggagtctGagatgcccaggctggctgca	15	10	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr14:105688029G>A	uc001yqp.2	-	11	1634	c.1271C>T	c.(1270-1272)TCA>TTA	p.S424L	BRF1_uc010tyo.1_Missense_Mutation_p.S309L|BRF1_uc010typ.1_Missense_Mutation_p.S309L|BRF1_uc001yqk.2_5'UTR|BRF1_uc001yql.2_Missense_Mutation_p.S220L|BRF1_uc001yqo.2_Missense_Mutation_p.S186L|BRF1_uc010axg.1_Missense_Mutation_p.S397L|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron|BRF1_uc010axi.1_5'UTR	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	424					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		GATGGAGTCTGAGATGCCCAG	0.672													0	0	0	0.001984	0	6	19										A	105688029	G	A	105688029	3	1	12	1	0	0	0	0	1	0	0	0	1510	1294	45	1	794	1	BRF1	14	105688029	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4892251	105688029	1661511	241	3080										
FMN1	342184	broad.mit.edu	37	chr15	33358805	33358805	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcatgtctcatcttgcgcttGagagcttccagctcagaggt	10	11	4	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:33358805G>C	uc001zhf.3	-	1	1281	c.1281C>G	c.(1279-1281)CTC>CTG	p.L427L	FMN1_uc001zhg.2_Silent_p.L427L	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TCTTGCGCTTGAGAGCTTCCA	0.532													0	0	0	0.001984	0	6	21										C	33358805	G	C	33358805	2	2	12	1	0	0	0	0	0	0	0	1	5949	1277	45	1		1	FMN1	15	33358805	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		33358805	69172587	242	3081										
RAD51	5888	broad.mit.edu	37	chr15	40993283	40993283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agtgtggcataaatgccaacGatgtgaagaaattggaagaa	12	4	0	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:40993283G>A	uc001zmi.3	+	3	408	c.109G>A	c.(109-111)GAT>AAT	p.D37N	RAD51_uc010bbw.2_Missense_Mutation_p.D37N|RAD51_uc010bbx.2_Missense_Mutation_p.D37N|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.D37N|RAD51_uc001zmm.1_RNA|RAD51_uc001zmn.1_5'UTR	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	37					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		AAATGCCAACGATGTGAAGAA	0.303								Homologous_recombination					0	0	0	0.008291	0	10	44										A	40993283	G	A	40993283	3	1	12	1	0	0	0	0	1	0	0	0	12985	1058	37	1	115	1	RAD51	15	40993283	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	7634478	40993283	61538109	243	3082										
DNAJC17	55192	broad.mit.edu	37	chr15	41071455	41071455	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttccttttctcatcaagtttCtgggtcctctctgctgcttg	7	12	4	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:41071455C>G	uc001zms.1	-	4	272	c.261G>C	c.(259-261)CAG>CAC	p.Q87H	DNAJC17_uc010bbz.1_RNA|DNAJC17_uc010bca.1_RNA|DNAJC17_uc010bcb.1_RNA	NM_018163	NP_060633	Q9NVM6	DJC17_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 17	87					protein folding		heat shock protein binding|nucleotide binding|RNA binding|unfolded protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CATCAAGTTTCTGGGTCCTCT	0.507													0	0	0	0.003163	0	14	89										G	41071455	C	G	41071455	3	3	12	1	0	0	0	0	1	0	0	0	4636	912	32	1	685	1	DNAJC17	15	41071455	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	78172	41071455	61459937	244	3083										
INO80	54617	broad.mit.edu	37	chr15	41272569	41272569	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcaaaggagaagaggcgcttGaaggtccaaagtcagcaagg	14	7	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:41272569G>A	uc001zni.2	-	36	4736	c.4523C>T	c.(4522-4524)TCA>TTA	p.S1508L	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1508	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						AGAGGCGCTTGAAGGTCCAAA	0.547													0	0	0	0.008291	0	10	52										A	41272569	G	A	41272569	3	1	12	1	0	0	0	0	1	0	0	0	7746	1294	45	1	151	1	INO80	15	41272569	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	201114	41272569	61258823	245	3084										
GANC	2595	broad.mit.edu	37	chr15	42632010	42632010	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggctctttggggaggaacacAcccgactcatccgagaagcc	12	13	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:42632010A>C	uc001zpi.2	+	17	2301	c.1987A>C	c.(1987-1989)ACC>CCC	p.T663P		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	663					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GGAGGAACACACCCGACTCAT	0.572													0	0	0	0.001168	0	5	41										C	42632010	A	C	42632010	3	2	12	1	0	0	0	0	1	0	0	0	6234	159	6	5	2053	5	GANC	15	42632010	Missense_Mutation	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	1359441	42632010	59899382	246	3085										
GANC	2595	broad.mit.edu	37	chr15	42632035	42632035	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	actcatccgagaagccatcaGagagcgctatggcctcctgc	10	14	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:42632035G>C	uc001zpi.2	+	17	2326	c.2012G>C	c.(2011-2013)AGA>ACA	p.R671T		NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	671					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GAAGCCATCAGAGAGCGCTAT	0.542													0	0	0	0.001168	0	6	41										C	42632035	G	C	42632035	3	2	12	1	0	0	0	0	1	0	0	0	6234	942	33	1	2078	1	GANC	15	42632035	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	25	42632035	59899357	247	3086										
DMXL2	23312	broad.mit.edu	37	chr15	51758502	51758502	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	accactatcagacaaaggaaGaaatggctgcaataaaaggt	9	7	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:51758502G>C	uc002abf.2	-	30	7621	c.7396C>G	c.(7396-7398)CTT>GTT	p.L2466V	DMXL2_uc002abd.2_Missense_Mutation_p.L537V|DMXL2_uc010ufy.1_Missense_Mutation_p.L2467V|DMXL2_uc010bfa.2_Missense_Mutation_p.L1830V	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2466						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GACAAAGGAAGAAATGGCTGC	0.209													0	0	0	0.001855	0	13	51										C	51758502	G	C	51758502	3	2	12	1	0	0	0	0	1	0	0	0	4595	942	33	1	1770	1	DMXL2	15	51758502	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	9126467	51758502	50772890	248	3087										
TMOD2	29767	broad.mit.edu	37	chr15	52074980	52074980	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gagaccaacactcacgtgaaGaagttcagcctggccgcaac	10	13	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:52074980G>A	uc002abk.2	+	7	908	c.687G>A	c.(685-687)AAG>AAA	p.K229K	TMOD2_uc002abl.3_Intron|TMOD2_uc010bfb.2_Silent_p.K185K	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	229					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		CTCACGTGAAGAAGTTCAGCC	0.433													0	0	0	0.000602	0	5	159										A	52074980	G	A	52074980	2	1	12	1	0	0	0	0	0	0	0	1	16231	933	33	1		1	TMOD2	15	52074980	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	316478	52074980	50456412	249	3088										
TMOD2	29767	broad.mit.edu	37	chr15	52075011	52075011	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggccgcaactcgcagcaatGaccctgtggccattgtgagt	12	12	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:52075011G>C	uc002abk.2	+	7	939	c.718G>C	c.(718-720)GAC>CAC	p.D240H	TMOD2_uc002abl.3_Intron|TMOD2_uc010bfb.2_Missense_Mutation_p.D196H	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	240					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		TCGCAGCAATGACCCTGTGGC	0.393													0	0	0	0.009096	0	4	121										C	52075011	G	C	52075011	3	2	12	1	0	0	0	0	1	0	0	0	16231	1290	45	1	740	1	TMOD2	15	52075011	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	31	52075011	50456381	250	3089										
FAM63B	54629	broad.mit.edu	37	chr15	59123984	59123984	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gttctataggctttgtagctGagcagtttctaaataacaca	8	7	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:59123984G>C	uc002afj.2	+	6	1439	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q	FAM63B_uc002afi.2_Missense_Mutation_p.E413Q|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_Intron	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	413										central_nervous_system(1)	1						CTTTGTAGCTGAGCAGTTTCT	0.338													0	0	0	0.000602	0	5	54										C	59123984	G	C	59123984	3	2	12	1	0	0	0	0	1	0	0	0	5597	1291	45	1	1259	1	FAM63B	15	59123984	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	7048973	59123984	43407408	251	3090										
TLN2	83660	broad.mit.edu	37	chr15	62944237	62944237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ataaaaagaaacagagacctCagaaaatccggatgctggat	9	7	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:62944237C>G	uc002alb.3	+	3	268	c.268C>G	c.(268-270)CAG>GAG	p.Q90E		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	90	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						ACAGAGACCTCAGAAAATCCG	0.403													0	0	0	0.006214	0	10	36										G	62944237	C	G	62944237	3	3	12	1	0	0	0	0	1	0	0	0	15945	827	29	1	278	1	TLN2	15	62944237	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	3820253	62944237	39587155	252	3091										
HERC1	8925	broad.mit.edu	37	chr15	63930948	63930948	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccaagacataatttgttcatCcatgccgttaatccatttac	4	11	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:63930948C>G	uc002amp.2	-	62	12077	c.11929G>C	c.(11929-11931)GAT>CAT	p.D3977H		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3977					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ATTTGTTCATCCATGCCGTTA	0.393													0	0	0	0.013537	0	12	236										G	63930948	C	G	63930948	3	3	12	1	0	0	0	0	1	0	0	0	7057	855	30	1	2724	1	HERC1	15	63930948	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	986711	63930948	38600444	253	3092										
ANKDD1A	348094	broad.mit.edu	37	chr15	65242076	65242076	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tctcaggcaccaggagctatCaggagcacggccaccgaatg	12	13	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:65242076C>G	uc002aoa.2	+	14	1395	c.1366C>G	c.(1366-1368)CAG>GAG	p.Q456E	ANKDD1A_uc002aoc.2_RNA|ANKDD1A_uc010bha.2_Missense_Mutation_p.Q333E	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	456	Death.				signal transduction					ovary(1)	1						CAGGAGCTATCAGGAGCACGG	0.622													0	0	0	0.004672	0	3	79										G	65242076	C	G	65242076	3	3	12	1	0	0	0	0	1	0	0	0	624	827	29	1	1420	1	ANKDD1A	15	65242076	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1311128	65242076	37289316	254	3093										
CLK3	1198	broad.mit.edu	37	chr15	74912356	74912356	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cccccttttggcagccatgaCcgcctgccctaccagaggag	10	17	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:74912356C>T	uc010uln.1	+	3	1064	c.603C>T	c.(601-603)GAC>GAT	p.D201D	CLK3_uc002ayg.3_Silent_p.D53D|CLK3_uc002ayh.3_5'UTR|CLK3_uc010ulm.1_Silent_p.D201D|CLK3_uc002ayj.3_Silent_p.D53D|CLK3_uc002ayk.3_5'UTR	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	201	Arg-rich.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						GCAGCCATGACCGCCTGCCCT	0.587													0	0	0	0.00245	0	13	51										T	74912356	C	T	74912356	2	4	12	1	0	0	0	0	0	0	0	1	3538	506	18	2		2	CLK3	15	74912356	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	9670280	74912356	27619036	255	3094										
EDC3	80153	broad.mit.edu	37	chr15	74927826	74927826	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtgatagattccaacatcttGacaaaattgggcaggaaaag	10	6	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:74927826G>C	uc002ayn.2	-	9	1604	c.1116C>G	c.(1114-1116)GTC>GTG	p.V372V	EDC3_uc002ayo.2_Silent_p.V372V|EDC3_uc002aym.2_Silent_p.V372V	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	372	YjeF N-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						CCAACATCTTGACAAAATTGG	0.522											OREG0023287	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	10	79										C	74927826	G	C	74927826	2	2	12	1	0	0	0	0	0	0	0	1	4907	1277	45	1		1	EDC3	15	74927826	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	15470	74927826	27603566	256	3095										
NTRK3	4916	broad.mit.edu	37	chr15	88476307	88476307	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	catgatgagggggtccccatCgccgcacactccatagaact	10	14	0	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr15:88476307C>T	uc002bme.1	-	15	1987	c.1825G>A	c.(1825-1827)GAT>AAT	p.D609N	NTRK3_uc002bmh.2_Missense_Mutation_p.D601N|NTRK3_uc002bmf.1_Missense_Mutation_p.D609N|NTRK3_uc010upl.1_Missense_Mutation_p.D511N|NTRK3_uc010bnh.1_Missense_Mutation_p.D601N	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	609	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGTCCCCATCGCCGCACACT	0.552			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.001168	0	6	46										T	88476307	C	T	88476307	3	4	12	1	0	0	0	0	1	0	0	0	10708	884	31	1	714	1	NTRK3	15	88476307	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	13548481	88476307	14055085	257	3096										
AXIN1	8312	broad.mit.edu	37	chr16	339472	339472	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttttggtcagcagctccttGaactggcccagggtgacagc	12	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:339472G>C	uc002cgp.1	-	10	2607	c.2430C>G	c.(2428-2430)TTC>TTG	p.F810L	AXIN1_uc002cgq.1_Missense_Mutation_p.F774L	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	810	DIX.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GCAGCTCCTTGAACTGGCCCA	0.627													0	0	0	0.00245	0	13	52										C	339472	G	C	339472	3	2	12	1	0	0	0	0	1	0	0	0	1236	1281	45	1	166	1	AXIN1	16	339472	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		339472	90015281	258	3097										
C16orf5	29965	broad.mit.edu	37	chr16	4563773	4563773	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggcattgggtgacccggcggCtcatagggtggggggccaat	19	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:4563773C>G	uc002cwu.2	-	3	460	c.165G>C	c.(163-165)GAG>GAC	p.E55D	C16orf5_uc002cwv.2_Missense_Mutation_p.E55D|C16orf5_uc002cww.2_Missense_Mutation_p.E55D|C16orf5_uc010uxl.1_Missense_Mutation_p.E55D|C16orf5_uc010uxm.1_Intron|C16orf5_uc010btu.2_RNA	NM_013399	NP_037531	Q9H305	LITFL_HUMAN	cell death inducing protein	55	Pro-rich.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|tumor necrosis factor-mediated signaling pathway	nucleus				ovary(1)	1		Ovarian(90;0.17)				GACCCGGCGGCTCATAGGGTG	0.647													0	0	0	0.003163	0	15	53										G	4563773	C	G	4563773	3	3	12	1	0	0	0	0	1	0	0	0	1817	796	28	4	473	4	C16orf5	16	4563773	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4224301	4563773	85790980	259	3098										
NPIP	9284	broad.mit.edu	37	chr16	15045813	15045813	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccctcagtggatgataatctCaagacacctcccgagtgtgt	9	12	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:15045813C>G	uc002dcy.3	+	8	984	c.984C>G	c.(982-984)CTC>CTG	p.L328L	NPIP_uc002dcx.3_RNA	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein	328	Pro-rich.				mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						ATGATAATCTCAAGACACCTC	0.468													0	0	0	0.001168	0	4	60										G	15045813	C	G	15045813	2	3	12	1	0	0	0	0	0	0	0	1	10584	813	29	1		1	NPIP	16	15045813	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	10482040	15045813	75308940	260	3099										
LAT	27040	broad.mit.edu	37	chr16	28997739	28997739	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cttgggggctcccaccggacGccatcttcccggcgggattc	13	16	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:28997739G>A	uc002dsd.2	+	5	634	c.282G>A	c.(280-282)ACG>ACA	p.T94T	uc010vct.1_Intron|LAT_uc010vdj.1_Silent_p.T130T|LAT_uc002dsb.2_Silent_p.T94T|LAT_uc002dsc.2_Silent_p.T93T|LAT_uc010vdk.1_Silent_p.T94T|LAT_uc010vdl.1_Silent_p.T93T	NM_014387	NP_055202	O43561	LAT_HUMAN	linker for activation of T cells isoform a	94	Cytoplasmic (Potential).				calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity				0		Hepatocellular(780;0.244)				CCCACCGGACGCCATCTTCCC	0.627													0	0	0	0.009535	0	29	67										A	28997739	G	A	28997739	2	1	12	1	0	0	0	0	0	0	0	1	8644	1074	38	2		2	LAT	16	28997739	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13951926	28997739	61357014	261	3100										
SPN	6693	broad.mit.edu	37	chr16	29676187	29676187	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggagccactggtggccagtGaggatggggctgtggacgcc	19	9	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:29676187G>A	uc002dtm.2	+	2	1274	c.1138G>A	c.(1138-1140)GAG>AAG	p.E380K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.E380K|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	380	Cytoplasmic (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						GGTGGCCAGTGAGGATGGGGC	0.652													0	0	0	0.000602	0	3	14										A	29676187	G	A	29676187	3	1	12	1	0	0	0	0	1	0	0	0	15072	1291	45	1	1140	1	SPN	16	29676187	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	678448	29676187	60678566	262	3101										
CORO1A	11151	broad.mit.edu	37	chr16	30199708	30199708	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgttccaggaggacctgtaCccacccaccgcagggcccga	11	17	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:30199708C>A	uc002dww.2	+	10	1214	c.1092C>A	c.(1090-1092)TAC>TAA	p.Y364*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Nonsense_Mutation_p.Y364*|CORO1A_uc010bzr.2_Intron|CORO1A_uc002dwx.2_Nonsense_Mutation_p.Y258*|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	364					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						AGGACCTGTACCCACCCACCG	0.647													1	0	6.05902e-23	0.003755	6.63898e-23	30	94										A	30199708	C	A	30199708	4	1	12	1	0	0	0	0	0	1	0	0	3753	518	18	4	1126	4	CORO1A	16	30199708	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	523521	30199708	60155045	263	3102										
GNAO1	2775	broad.mit.edu	37	chr16	56385394	56385394	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttcctcaacaagaaagatctCtttggcgagaagatcaagaa	8	8	3	5			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:56385394C>G	uc002eiu.3	+	7	1719	c.822C>G	c.(820-822)CTC>CTG	p.L274L		NM_020988	NP_066268	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	274					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				AGAAAGATCTCTTTGGCGAGA	0.498													0	0	0	0.001168	0	5	58										G	56385394	C	G	56385394	2	3	12	1	0	0	0	0	0	0	0	1	6508	900	32	1		1	GNAO1	16	56385394	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	26185686	56385394	33969359	264	3103										
NLRC5	84166	broad.mit.edu	37	chr16	57059987	57059987	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gggtggaagaatatgtgaatCacttcttcagcgcccagcca	11	10	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:57059987C>A	uc002ekk.1	+	6	1357	c.1132C>A	c.(1132-1134)CAC>AAC	p.H378N	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.H183N|NLRC5_uc002ekl.2_Missense_Mutation_p.H183N|NLRC5_uc002ekm.2_Missense_Mutation_p.H183N|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	378	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				ATATGTGAATCACTTCTTCAG	0.537													1	0	1.01871e-10	0.008871	1.10234e-10	19	115										A	57059987	C	A	57059987	3	1	12	1	0	0	0	0	1	0	0	0	10470	826	29	3	1146	3	NLRC5	16	57059987	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	674593	57059987	33294766	265	3104										
CDH16	1014	broad.mit.edu	37	chr16	66950200	66950200	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tagctggtactctgcctgctCctctcggtccagggccctgg	12	15	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:66950200C>T	uc002eql.2	-	4	335	c.262G>A	c.(262-264)GAG>AAG	p.E88K	CDH16_uc010cdy.2_Missense_Mutation_p.E88K|CDH16_uc002eqm.2_Missense_Mutation_p.E88K	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	88	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCTGCCTGCTCCTCTCGGTCC	0.622													0	0	0	0.008291	0	10	54										T	66950200	C	T	66950200	3	4	12	1	0	0	0	0	1	0	0	0	3101	864	30	1	2287	1	CDH16	16	66950200	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	9890213	66950200	23404553	266	3105										
PHLPP2	23035	broad.mit.edu	37	chr16	71701149	71701149	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgctgaagatccagcacctcGagggggatgtgctctaccag	13	11	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr16:71701149G>C	uc002fax.2	-	11	1722	c.1716C>G	c.(1714-1716)CTC>CTG	p.L572L	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Silent_p.L572L	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	572	LRR 15.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CCAGCACCTCGAGGGGGATGT	0.478													0	0	0	0.001168	0	6	71										C	71701149	G	C	71701149	2	2	12	1	0	0	0	0	0	0	0	1	11855	1045	37	1		1	PHLPP2	16	71701149	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4750949	71701149	18653604	267	3106										
KIAA0664	23277	broad.mit.edu	37	chr17	2605236	2605236	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcgccgtcggtgaagacactCaggaaggacaaggagttgca	14	9	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:2605236C>G	uc002fuy.1	-	4	563	c.477G>C	c.(475-477)CTG>CTC	p.L159L	KIAA0664_uc002fux.1_Silent_p.L91L	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	159							binding			breast(2)	2						TGAAGACACTCAGGAAGGACA	0.667													0	0	0	0.004482	0	6	42										G	2605236	C	G	2605236	2	3	12	1	0	0	0	0	0	0	0	1	8189	813	29	1		1	KIAA0664	17	2605236	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		2605236	78589974	268	3107										
GGT6	124975	broad.mit.edu	37	chr17	4461953	4461953	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gcacctccacccccaggtctCccgccagtagactcagtaga	8	18	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:4461953C>T	uc002fyd.3	-	4	899	c.839G>A	c.(838-840)GGA>GAA	p.G280E	GGT6_uc010vsb.1_Missense_Mutation_p.G132E|GGT6_uc002fyc.3_Missense_Mutation_p.G248E|GGT6_uc010vsc.1_Missense_Mutation_p.G286E	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	280	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1						CCCCAGGTCTCCCGCCAGTAG	0.657													0	0	0	0.006122	0	17	5										T	4461953	C	T	4461953	3	4	12	1	0	0	0	0	1	0	0	0	6363	855	30	1	646	1	GGT6	17	4461953	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1856717	4461953	76733257	269	3108										
DHX33	56919	broad.mit.edu	37	chr17	5365687	5365687	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctcctcttctgtgcagctttCaccactccaaagagcacatc	5	16	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:5365687C>T	uc002gca.2	-	3	632	c.630G>A	c.(628-630)GTG>GTA	p.V210V	DHX33_uc002gbz.2_5'Flank|DHX33_uc002gcb.2_Silent_p.V37V|DHX33_uc010clf.2_Intron	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	210	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GTGCAGCTTTCACCACTCCAA	0.453													0	0	0	0.004878	0	38	19										T	5365687	C	T	5365687	2	4	12	1	0	0	0	0	0	0	0	1	4506	813	29	1		1	DHX33	17	5365687	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	903734	5365687	75829523	270	3109										
CD68	968	broad.mit.edu	37	chr17	7483018	7483018	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaggctggctgtgcttttctCgggggccctgctggggctac	17	11	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:7483018C>T	uc002ghv.2	+	1	214	c.23C>T	c.(22-24)TCG>TTG	p.S8L	CD68_uc002ghu.2_Missense_Mutation_p.S8L	NM_001251	NP_001242	P34810	CD68_HUMAN	CD68 antigen isoform A	8						endosome membrane|integral to membrane|lysosomal membrane|membrane fraction|plasma membrane					0						GTGCTTTTCTCGGGGGCCCTG	0.642													0	0	0	0.004007	0	15	5										T	7483018	C	T	7483018	3	4	12	1	0	0	0	0	1	0	0	0	3030	893	31	1	25	1	CD68	17	7483018	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2117331	7483018	73712192	271	3110										
TP53	7157	broad.mit.edu	37	chr17	7578513	7578513	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cacagctgcacagggcaggtCttggccagttggcaaaacat	12	11	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:7578513C>G	uc002gim.2	-	5	611	c.417G>C	c.(415-417)AAG>AAC	p.K139N	TP53_uc002gig.1_Missense_Mutation_p.K139N|TP53_uc002gih.2_Missense_Mutation_p.K139N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.K7N|TP53_uc010cng.1_Missense_Mutation_p.K7N|TP53_uc002gii.1_Missense_Mutation_p.K7N|TP53_uc010cnh.1_Missense_Mutation_p.K139N|TP53_uc010cni.1_Missense_Mutation_p.K139N|TP53_uc002gij.2_Missense_Mutation_p.K139N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K46N|TP53_uc002gio.2_Missense_Mutation_p.K7N|TP53_uc010vug.1_Missense_Mutation_p.K100N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	139	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> N (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K139N(8)|p.K139K(7)|p.0?(7)|p.K139fs*31(4)|p.K139fs*9(3)|p.K139Q(2)|p.K139R(2)|p.K139E(2)|p.N131fs*27(2)|p.K139*(2)|p.K139T(1)|p.L137_W146del10(1)|p.K139fs*4(1)|p.F134_T140>S(1)|p.A138_V143delAKTCPV(1)|p.K139fs*11(1)|p.K139fs*10(1)|p.A138_P142delAKTCP(1)|p.Q136_K139delQLAK(1)|p.K139_C141>N(1)|p.C135_T140delCQLAKT(1)|p.K139fs*29(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGCAGGTCTTGGCCAGTT	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.013114	0	41	12										G	7578513	C	G	7578513	3	3	12	1	0	0	0	0	1	0	0	0	16378	912	32	1	881	1	TP53	17	7578513	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	95495	7578513	73616697	272	3111										
MYH10	4628	broad.mit.edu	37	chr17	8395764	8395764	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggtttctttctctctggcctCggcttcggcccggtcccgct	11	16	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:8395764C>T	uc002gll.2	-	32	4525	c.4429G>A	c.(4429-4431)GAG>AAG	p.E1477K	MYH10_uc002glm.2_Missense_Mutation_p.E1508K|MYH10_uc010cnx.2_Missense_Mutation_p.E1486K	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1477	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCTCTGGCCTCGGCTTCGGCC	0.592													0	0	0	0.009096	0	4	72										T	8395764	C	T	8395764	3	4	12	1	0	0	0	0	1	0	0	0	10030	893	31	1	1541	1	MYH10	17	8395764	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	817251	8395764	72799446	273	3112										
MYH13	8735	broad.mit.edu	37	chr17	10209797	10209797	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cggttctccagtttctggatCtgcttcttcccgcccttcag	8	15	5	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:10209797C>A	uc002gmk.1	-	37	5535	c.5445G>T	c.(5443-5445)CAG>CAT	p.Q1815H		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1815	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTTTCTGGATCTGCTTCTTCC	0.537													1	0	8.00594e-06	0.007413	8.47344e-06	19	184										A	10209797	C	A	10209797	3	1	12	1	0	0	0	0	1	0	0	0	10032	912	32	3	391	3	MYH13	17	10209797	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1814033	10209797	70985413	274	3113										
UNC119	9094	broad.mit.edu	37	chr17	26879509	26879509	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggtatgggggccacgctctGgcccgagggccccggagcgg	19	13	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:26879509G>A	uc002hbk.2	-	1	138	c.67C>T	c.(67-69)CAG>TAG	p.Q23*	UNC119_uc002hbm.2_Nonsense_Mutation_p.Q23*	NM_005148	NP_005139	Q13432	U119A_HUMAN	unc119 (C.elegans) homolog isoform a	23					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction					0	Lung NSC(42;0.00431)					GCCACGCTCTGGCCCGAGGGC	0.751													0	0	0	0.004672	0	3	8										A	26879509	G	A	26879509	4	1	12	1	0	0	0	0	0	1	0	0	16979	1357	47	2	728	2	UNC119	17	26879509	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	16669712	26879509	54315701	275	3114										
CPD	1362	broad.mit.edu	37	chr17	28749923	28749923	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cctgatatggaaatcttcttGagaaggtttgccaatgaata	9	6	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:28749923G>C	uc002hfb.1	+	5	1554	c.1539G>C	c.(1537-1539)TTG>TTC	p.L513F	CPD_uc010wbo.1_Missense_Mutation_p.L266F|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	513	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AAATCTTCTTGAGAAGGTTTG	0.393													0	0	0	0.00874	0	38	76										C	28749923	G	C	28749923	3	2	12	1	0	0	0	0	1	0	0	0	3798	1281	45	1	1557	1	CPD	17	28749923	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1870414	28749923	52445287	276	3115										
PSMD11	5717	broad.mit.edu	37	chr17	30807593	30807593	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aagctgctctggaaacaattCagaacatgagcaaagtagtg	10	7	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:30807593C>T	uc010cta.1	+	13	1253	c.1213C>T	c.(1213-1215)CAG>TAG	p.Q405*	PSMD11_uc002hhm.2_Nonsense_Mutation_p.Q405*	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	405					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			GGAAACAATTCAGAACATGAG	0.483													0	0	0	0.009096	0	4	78										T	30807593	C	T	30807593	4	4	12	1	0	0	0	0	0	1	0	0	12694	827	29	1	1263	1	PSMD11	17	30807593	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2057670	30807593	50387617	277	3116										
NBR1	4077	broad.mit.edu	37	chr17	41329983	41329983	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	catttgatctgaatactattCaaataaaatacctggatgag	6	6	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:41329983C>G	uc010czd.2	+	3	273	c.133C>G	c.(133-135)CAA>GAA	p.Q45E	NBR1_uc010diz.2_Missense_Mutation_p.Q45E|NBR1_uc010whu.1_Missense_Mutation_p.Q45E|NBR1_uc010whv.1_Missense_Mutation_p.Q45E|NBR1_uc010whw.1_Intron	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	45	OPR.				macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GAATACTATTCAAATAAAATA	0.308													0	0	0	0.004672	0	3	28										G	41329983	C	G	41329983	3	3	12	1	0	0	0	0	1	0	0	0	10200	827	29	1	139	1	NBR1	17	41329983	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	10522390	41329983	39865227	278	3117										
MPP3	4356	broad.mit.edu	37	chr17	41907106	41907106	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atattgtcaggcagaggcggGagaacggggtcaaaattctt	14	6	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:41907106G>A	uc002iei.3	-	7	523	c.357C>T	c.(355-357)CTC>CTT	p.L119L	MPP3_uc002ieh.2_Silent_p.L144L|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Silent_p.L119L|MPP3_uc010wik.1_Silent_p.L144L|MPP3_uc010czj.1_3'UTR	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	119					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GCAGAGGCGGGAGAACGGGGT	0.557													0	0	0	0.00333	0	23	91										A	41907106	G	A	41907106	2	1	12	1	0	0	0	0	0	0	0	1	9735	1161	41	1		1	MPP3	17	41907106	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	577123	41907106	39288104	279	3118										
C17orf53	78995	broad.mit.edu	37	chr17	42232692	42232692	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcacttcgaaatcactacctCaacgtgacacccaacaacct	3	16	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:42232692C>A	uc002ifi.1	+	8	1871	c.1686C>A	c.(1684-1686)CTC>CTA	p.L562L	C17orf53_uc010czq.1_Silent_p.L561L|C17orf53_uc002ifj.1_Silent_p.L486L|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	562											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		ATCACTACCTCAACGTGACAC	0.527													1	0	2.56e-06	0.009096	2.72274e-06	4	103										A	42232692	C	A	42232692	2	1	12	1	0	0	0	0	0	0	0	1	1862	813	29	3		3	C17orf53	17	42232692	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	325586	42232692	38962518	280	3119										
ASB16	92591	broad.mit.edu	37	chr17	42255693	42255693	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gctgccggcagggtgccaccCggctgccactgcccccgctc	13	20	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:42255693C>G	uc002ifl.1	+	5	1381	c.1297C>G	c.(1297-1299)CGG>GGG	p.R433G	ASB16_uc002ifm.1_RNA|C17orf65_uc002ifn.2_Intron	NM_080863	NP_543139	Q96NS5	ASB16_HUMAN	ankyrin repeat and SOCS box-containing protein	433	SOCS box.				intracellular signal transduction		protein binding			kidney(2)	2		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGGTGCCACCCGGCTGCCACT	0.677													0	0	0	0.001984	0	6	13										G	42255693	C	G	42255693	3	3	12	1	0	0	0	0	1	0	0	0	1020	643	23	4	1315	4	ASB16	17	42255693	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	23001	42255693	38939517	281	3120										
EFTUD2	9343	broad.mit.edu	37	chr17	42936546	42936546	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cacatgctcgccagactcctCcacctgaaacacaacaggca	6	17	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:42936546C>G	uc002ihn.2	-	19	2125	c.1864G>C	c.(1864-1866)GAG>CAG	p.E622Q	EFTUD2_uc010wje.1_Missense_Mutation_p.E587Q|EFTUD2_uc010wjf.1_Missense_Mutation_p.E612Q	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	622						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				CCAGACTCCTCCACCTGAAAC	0.502													0	0	0	0.00308	0	8	73										G	42936546	C	G	42936546	3	3	12	1	0	0	0	0	1	0	0	0	4961	864	30	1	1094	1	EFTUD2	17	42936546	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	680853	42936546	38258664	282	3121										
ARHGAP27	201176	broad.mit.edu	37	chr17	43473589	43473589	+	Frame_Shift_Del	DEL	G	G	-													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcaccgtggtccaccttataGcgtagcttctggatggtggc							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:43473589delG	uc002iix.2	-	14	1661	c.1212delC	c.(1210-1212)CGCfs	p.R404fs	ARHGAP27_uc010dak.2_Frame_Shift_Del_p.R377fs	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	745	Rho-GAP.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					CCACCTTATAGCGTAGCTTCT	0.647																		32	57	---	---								-	43473589	G	-	43473589	7	5	12	1	0	1	0	1	0	0	0	0	876	958	34	0	450	0	ARHGAP27	17	43473589	Frame_Shift_Del	DEL	G	TCGA-BT-A20R-01A-12D-A16O-08	537043	43473589	37721621	283	3122										
TEX14	56155	broad.mit.edu	37	chr17	56690847	56690847	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtacacaaggcgggttttctCtaggtcctgggagagacaca	13	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:56690847C>G	uc010dcz.1	-	9	1076	c.958G>C	c.(958-960)GAG>CAG	p.E320Q	TEX14_uc002iwr.1_Missense_Mutation_p.E314Q|TEX14_uc002iws.1_Missense_Mutation_p.E314Q|TEX14_uc010dda.1_Missense_Mutation_p.E94Q	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	320	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGGTTTTCTCTAGGTCCTGG	0.498													0	0	0	0.012213	0	30	57										G	56690847	C	G	56690847	3	3	12	1	0	0	0	0	1	0	0	0	15775	922	32	1	3635	1	TEX14	17	56690847	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	13217258	56690847	24504363	284	3123										
TMEM49	81671	broad.mit.edu	37	chr17	57917167	57917167	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tggatgtttgaaaagttggtCgttgtcatggtgtgttactt	13	3	1	1	rs111262775	byFrequency	TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:57917167C>T	uc002ixu.3	+	12	1389	c.1116C>T	c.(1114-1116)GTC>GTT	p.V372V	TMEM49_uc010wog.1_Silent_p.V180V|TMEM49_uc010woh.1_Silent_p.V316V|TMEM49_uc010woi.1_Silent_p.V275V|TMEM49_uc010woj.1_Silent_p.V238V|TMEM49_uc002ixv.2_RNA|MIR21_hsa-mir-21|MI0000077_5'Flank	NM_030938	NP_112200	Q96GC9	VMP1_HUMAN	transmembrane protein 49	372	Helical; (Potential).				autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)			AAAAGTTGGTCGTTGTCATGG	0.388													0	0	0	0.013726	0	32	195										T	57917167	C	T	57917167	2	4	12	1	0	0	0	0	0	0	0	1	16170	871	31	1		1	TMEM49	17	57917167	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1226320	57917167	23278043	285	3124										
TLK2	11011	broad.mit.edu	37	chr17	60683562	60683562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaataaagttgatgtgtggtCggtgggtgtgatcttctatc	13	4	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:60683562C>T	uc010ddp.2	+	21	2265	c.1997C>T	c.(1996-1998)TCG>TTG	p.S666L	TLK2_uc002izx.3_Missense_Mutation_p.S492L|TLK2_uc002izz.3_Missense_Mutation_p.S644L|TLK2_uc002jaa.3_Missense_Mutation_p.S612L|TLK2_uc010wpd.1_Missense_Mutation_p.S612L	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	666	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						GATGTGTGGTCGGTGGGTGTG	0.398													0	0	0	0.000602	0	3	36										T	60683562	C	T	60683562	3	4	12	1	0	0	0	0	1	0	0	0	15941	893	31	1	2005	1	TLK2	17	60683562	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2766395	60683562	20511648	286	3125										
STRADA	92335	broad.mit.edu	37	chr17	61787963	61787963	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gaagtgtgtacagatgagatCttttgcagaacctgcagaaa	11	6	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:61787963C>G	uc002jbm.2	-	8	628	c.469G>C	c.(469-471)GAT>CAT	p.D157H	STRADA_uc002jbn.2_Missense_Mutation_p.D99H|STRADA_uc002jbo.2_Missense_Mutation_p.D120H|STRADA_uc002jbp.2_Missense_Mutation_p.D120H|STRADA_uc002jbq.2_Missense_Mutation_p.D99H|STRADA_uc010wpq.1_Missense_Mutation_p.D113H|STRADA_uc010wpr.1_Missense_Mutation_p.D128H|STRADA_uc010ddw.2_Missense_Mutation_p.D128H|STRADA_uc002jbr.2_Missense_Mutation_p.D99H	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	157	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						CAGATGAGATCTTTTGCAGAA	0.498													0	0	0	0.001168	0	6	35										G	61787963	C	G	61787963	3	3	12	1	0	0	0	0	1	0	0	0	15323	913	32	1	908	1	STRADA	17	61787963	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1104401	61787963	19407247	287	3126										
GH1	2688	broad.mit.edu	37	chr17	61995219	61995219	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgttggcgaagacactcctGaggaactgcacgggctccag	13	12	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:61995219G>A	uc002jdj.2	-	4	419	c.357C>T	c.(355-357)CTC>CTT	p.L119L	GH1_uc002jdi.2_Silent_p.L104L|GH1_uc002jdk.2_Silent_p.L79L|GH1_uc002jdl.2_Intron|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Intron	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	119					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						AGACACTCCTGAGGAACTGCA	0.607													0	0	0	0.001855	0	13	80										A	61995219	G	A	61995219	2	1	12	1	0	0	0	0	0	0	0	1	6367	1277	45	1		1	GH1	17	61995219	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	207256	61995219	19199991	288	3127										
CACNG5	27091	broad.mit.edu	37	chr17	64880683	64880683	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	acatctccagcatcaacgatGagatgctcaacaggaccaag	8	12	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:64880683G>A	uc010wqi.1	+	5	712	c.475G>A	c.(475-477)GAG>AAG	p.E159K	CACNG5_uc002jfr.2_Missense_Mutation_p.E159K|CACNG5_uc010wqj.1_Missense_Mutation_p.E159K	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	159					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CATCAACGATGAGATGCTCAA	0.562													0	0	0	0.008291	0	10	71										A	64880683	G	A	64880683	3	1	12	1	0	0	0	0	1	0	0	0	2560	1291	45	1	489	1	CACNG5	17	64880683	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	2885464	64880683	16314527	289	3128										
ABCA8	10351	broad.mit.edu	37	chr17	66872823	66872823	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggagacttcagctggtcctgCagcttgagcgcatccactaa	11	12	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:66872823C>T	uc002jhp.2	-	32	4280	c.4101G>A	c.(4099-4101)CTG>CTA	p.L1367L	ABCA8_uc002jhq.2_Silent_p.L1407L|ABCA8_uc010wqq.1_Silent_p.L1402L	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1367	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GCTGGTCCTGCAGCTTGAGCG	0.498													0	0	0	0.00333	0	22	75										T	66872823	C	T	66872823	2	4	12	1	0	0	0	0	0	0	0	1	38	697	25	2		2	ABCA8	17	66872823	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1992140	66872823	14322387	290	3129										
GRIN2C	2905	broad.mit.edu	37	chr17	72845996	72845996	+	Missense_Mutation	SNP	G	G	T													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccgtctccacaaagggtacaGagaagtctacgatctcggag							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:72845996G>T	uc002jlt.1	-	7	1724	c.1568C>A	c.(1567-1569)TCT>TAT	p.S523Y	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.S523Y	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	523	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	AAAGGGTACAGAGAAGTCTAC	0.622													1	0	1.85244e-09	0.00333	1.99458e-09	25	76										T	72845996	G	T	72845996	3	4	12	1	0	0	0	0	1	0	0	0	6781	942	33	3	2161	3	GRIN2C	17	72845996	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	5973173	72845996	8349214	291	3130	19	2								
GRIN2C	2905	broad.mit.edu	37	chr17	72846001	72846001	+	Silent	SNP	G	G	A													0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccacaaagggtacagagaaGtctacgatctcggagcgttc							TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:72846001G>A	uc002jlt.1	-	7	1719	c.1563C>T	c.(1561-1563)GAC>GAT	p.D521D	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.D521D	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	521	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GTACAGAGAAGTCTACGATCT	0.617													0	0	0	0.00632	0	28	72										A	72846001	G	A	72846001	2	1	12	1	0	0	0	0	0	0	0	1	6781	1020	36	2		2	GRIN2C	17	72846001	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	5	72846001	8349209	292	3131	19	2								
NUP85	79902	broad.mit.edu	37	chr17	73204673	73204673	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaatgtattttgactggggtCcaggggagatgctggtatgt	15	4	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:73204673C>G	uc002jng.1	+	2	345	c.85C>G	c.(85-87)CCA>GCA	p.P29A	NUP85_uc010dgd.1_Missense_Mutation_p.P29A|NUP85_uc010wrv.1_Intron	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	29					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			TGACTGGGGTCCAGGGGAGAT	0.358													0	0	0	0.001984	0	6	241										G	73204673	C	G	73204673	3	3	12	1	0	0	0	0	1	0	0	0	10770	855	30	1	91	1	NUP85	17	73204673	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	358672	73204673	7990537	293	3132										
PCYT2	5833	broad.mit.edu	37	chr17	79864646	79864646	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cagaggatacggaacaggtcGaaggcaccagccacatagat	12	10	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:79864646G>A	uc002kcf.1	-	7	729	c.666C>T	c.(664-666)TTC>TTT	p.F222F	PCYT2_uc010wva.1_Silent_p.F190F|PCYT2_uc010wvb.1_Silent_p.F190F|PCYT2_uc002kce.1_Silent_p.F144F|PCYT2_uc002kcg.1_Silent_p.F251F|PCYT2_uc002kch.1_Silent_p.F240F|PCYT2_uc002kci.1_Silent_p.F181F|PCYT2_uc010dii.1_Silent_p.F222F|PCYT2_uc010wvc.1_Silent_p.F144F	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	222	Catalytic 2 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GGAACAGGTCGAAGGCACCAG	0.607													0	0	0	0.006122	0	16	32										A	79864646	G	A	79864646	2	1	12	1	0	0	0	0	0	0	0	1	11612	1049	37	1		1	PCYT2	17	79864646	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	6659973	79864646	1330564	294	3133										
CD7	924	broad.mit.edu	37	chr17	80274695	80274695	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cgatgcggccccggaaccgtCtgtccgtagtgggcaccacc	13	16	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr17:80274695C>T	uc002kel.1	-	2	354	c.245G>A	c.(244-246)AGA>AAA	p.R82K	CD7_uc010din.2_Missense_Mutation_p.R82K|CD7_uc002kem.2_Silent_p.Q63Q|CD7_uc010wvk.1_Missense_Mutation_p.R82K	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	82	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			CCGGAACCGTCTGTCCGTAGT	0.637													0	0	0	0.003271	0	37	84										T	80274695	C	T	80274695	3	4	12	1	0	0	0	0	1	0	0	0	3032	913	32	1	489	1	CD7	17	80274695	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	410049	80274695	920515	295	3134										
TWSG1	57045	broad.mit.edu	37	chr18	9396405	9396405	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatactcagttgaattggaaCatcgtttctttccctgttgc	8	9	2	1	rs143807731		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:9396405C>T	uc002knz.2	+	4	542	c.351C>T	c.(349-351)AAC>AAT	p.N117N	TWSG1_uc002koa.2_Silent_p.N42N	NM_020648	NP_065699	Q9GZX9	TWSG1_HUMAN	twisted gastrulation precursor	117										ovary(1)|pancreas(1)	2						TGAATTGGAACATCGTTTCTT	0.463													0	0	0	0.004007	0	14	92										T	9396405	C	T	9396405	2	4	12	1	0	0	0	0	0	0	0	1	16782	477	17	2		2	TWSG1	18	9396405	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		9396405	68680843	296	3135										
POTEC	388468	broad.mit.edu	37	chr18	14513681	14513681	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctcagaattcattttcttttCagccacttctatctgctttt	3	11	6	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:14513681C>T	uc010dln.2	-	10	1967	c.1513G>A	c.(1513-1515)GAA>AAA	p.E505K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	505	Potential.									skin(3)	3						ATTTTCTTTTCAGCCACTTCT	0.299													0	0	0	0.003163	0	15	60										T	14513681	C	T	14513681	3	4	12	1	0	0	0	0	1	0	0	0	12262	835	29	1	123	1	POTEC	18	14513681	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5117276	14513681	63563567	297	3136										
ROCK1	6093	broad.mit.edu	37	chr18	18629788	18629788	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	accaatcaccttcactacttCataatcttcagctttcattc	1	14	6	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:18629788C>T	uc002kte.2	-	3	1170	c.229G>A	c.(229-231)GAA>AAA	p.E77K		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	77	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TTCACTACTTCATAATCTTCA	0.274													0	0	0	0.001855	0	11	15										T	18629788	C	T	18629788	3	4	12	1	0	0	0	0	1	0	0	0	13517	835	29	1	3959	1	ROCK1	18	18629788	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	4116107	18629788	59447460	298	3137										
ASXL3	80816	broad.mit.edu	37	chr18	31323516	31323516	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	catgctttttaataaaaattCtgtccctgtatctgtttgca	5	8	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:31323516C>T	uc010dmg.1	+	12	3759	c.3704C>T	c.(3703-3705)TCT>TTT	p.S1235F	ASXL3_uc002kxq.2_Missense_Mutation_p.S942F	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1235	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AATAAAAATTCTGTCCCTGTA	0.373													0	0	0	0.00308	0	8	128										T	31323516	C	T	31323516	3	4	12	1	0	0	0	0	1	0	0	0	1068	913	32	1	3750	1	ASXL3	18	31323516	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	12693728	31323516	46753732	299	3138										
NARS	4677	broad.mit.edu	37	chr18	55270142	55270142	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gattggttcattaatggtgtCtgtcatcagtctctcaggag	11	7	6	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:55270142C>T	uc002lgs.2	-	12	1513	c.1285G>A	c.(1285-1287)GAC>AAC	p.D429N	NARS_uc002lgt.2_Missense_Mutation_p.D428N|NARS_uc010xea.1_Missense_Mutation_p.D180N	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	429					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)	TTAATGGTGTCTGTCATCAGT	0.448													0	0	0	0.001984	0	6	53										T	55270142	C	T	55270142	3	4	12	1	0	0	0	0	1	0	0	0	10170	913	32	1	373	1	NARS	18	55270142	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	23946626	55270142	22807106	300	3139										
CDH7	1005	broad.mit.edu	37	chr18	63477229	63477229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggagttcccgaaatgtctcCcgtgggtaagtaaagaacac	11	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr18:63477229C>T	uc002ljz.2	+	3	825	c.500C>T	c.(499-501)CCC>CTC	p.P167L	CDH7_uc002lka.2_Missense_Mutation_p.P167L|CDH7_uc002lkb.2_Missense_Mutation_p.P167L	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	167	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GAAATGTCTCCCGTGGGTAAG	0.398													0	0	0	0.010818	0	31	46										T	63477229	C	T	63477229	3	4	12	1	0	0	0	0	1	0	0	0	3115	623	22	2	506	2	CDH7	18	63477229	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	8207087	63477229	14600019	301	3140										
TMEM146	257062	broad.mit.edu	37	chr19	5771022	5771022	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgcacgtgttttactcctacCagcagctgggctgtcctctc	9	14	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:5771022C>G	uc002mda.2	+	19	1763	c.1702C>G	c.(1702-1704)CAG>GAG	p.Q568E	TMEM146_uc010duj.1_Missense_Mutation_p.Q226E	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	568	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTACTCCTACCAGCAGCTGGG	0.607													0	0	0	0.013537	0	13	50										G	5771022	C	G	5771022	3	3	12	1	0	0	0	0	1	0	0	0	16057	595	21	4	1776	4	TMEM146	19	5771022	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		5771022	53357961	302	3141										
INSR	3643	broad.mit.edu	37	chr19	7125313	7125313	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccacgtgatggcaggtgaagCccttcatgaccgaggcctca	12	13	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:7125313C>G	uc002mgd.1	-	17	3348	c.3239G>C	c.(3238-3240)GGC>GCC	p.G1080A	INSR_uc002mge.1_Missense_Mutation_p.G1068A	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1080	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCAGGTGAAGCCCTTCATGAC	0.607													0	0	0	0.000602	0	5	43										G	7125313	C	G	7125313	3	3	12	1	0	0	0	0	1	0	0	0	7773	739	26	4	933	4	INSR	19	7125313	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1354291	7125313	52003670	303	3142										
ZNF266	10781	broad.mit.edu	37	chr19	9526415	9526415	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	taagttgcactttccattctGaagctgaagagaaaaagaaa	8	6	1	4			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:9526415G>T	uc002mll.2	-	3	385	c.119C>A	c.(118-120)TCA>TAA	p.S40*	ZNF266_uc002mlm.2_Nonsense_Mutation_p.S40*|ZNF266_uc002mln.2_Nonsense_Mutation_p.S40*|ZNF266_uc002mlo.2_Nonsense_Mutation_p.S40*|ZNF266_uc010dwp.2_Nonsense_Mutation_p.S40*|ZNF266_uc010dwq.2_Nonsense_Mutation_p.S40*	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTCCATTCTGAAGCTGAAGA	0.398													1	0	4.3838e-07	0.001855	4.69693e-07	13	25										T	9526415	G	T	9526415	4	4	12	1	0	0	0	0	0	1	0	0	17802	1294	45	3	1538	3	ZNF266	19	9526415	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	2401102	9526415	49602568	304	3143										
KRI1	65095	broad.mit.edu	37	chr19	10670041	10670041	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatgagggccgcacctgcatGagctggtcgtgctgggcagg	18	10	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:10670041G>A	uc002moy.1	-	12	1215	c.1206C>T	c.(1204-1206)CTC>CTT	p.L402L	KRI1_uc002mow.1_Silent_p.L21L|KRI1_uc002mox.1_Silent_p.L398L	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	402	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GCACCTGCATGAGCTGGTCGT	0.488													0	0	0	0.006214	0	10	34										A	10670041	G	A	10670041	2	1	12	1	0	0	0	0	0	0	0	1	8444	1277	45	1		1	KRI1	19	10670041	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1143626	10670041	48458942	305	3144										
HSH2D	84941	broad.mit.edu	37	chr19	16268238	16268238	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cctcgccactgtgaacttgtCgtcactcttggatgtccgga	10	13	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:16268238C>T	uc002ndp.3	+	9	1223	c.692C>T	c.(691-693)TCG>TTG	p.S231L	HSH2D_uc002ndr.2_Silent_p.V174V|HSH2D_uc010ead.2_RNA	NM_032855	NP_116244	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	231						cytoplasm|nucleus					0						GTGAACTTGTCGTCACTCTTG	0.602													0	0	0	0.00308	0	8	74										T	16268238	C	T	16268238	3	4	12	1	0	0	0	0	1	0	0	0	7400	871	31	1	711	1	HSH2D	19	16268238	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5598197	16268238	42860745	306	3145										
F2RL3	9002	broad.mit.edu	37	chr19	17000948	17000948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccggctggcgcgctccgatcGcgtgctctgccatgacgcgc	14	17	1	1	rs147915788		TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:17000948G>A	uc002nfa.2	+	2	849	c.674G>A	c.(673-675)CGC>CAC	p.R225H		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	225	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						CGCTCCGATCGCGTGCTCTGC	0.697													0	0	0	0.000602	0	4	14										A	17000948	G	A	17000948	3	1	12	1	0	0	0	0	1	0	0	0	5346	1087	38	2	680	2	F2RL3	19	17000948	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	732710	17000948	42128035	307	3146										
MRPL34	64981	broad.mit.edu	37	chr19	17417150	17417150	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccggcgtgcaggtcatccttCgccgaatgctcaagggccgc	13	15	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:17417150C>T	uc002ngc.1	+	2	466	c.241C>T	c.(241-243)CGC>TGC	p.R81C	ABHD8_uc002ngb.3_5'Flank	NM_023937	NP_076426	Q9BQ48	RM34_HUMAN	mitochondrial ribosomal protein L34 precursor	81					translation		structural constituent of ribosome				0						GGTCATCCTTCGCCGAATGCT	0.652													0	0	0	0.004672	0	3	14										T	17417150	C	T	17417150	3	4	12	1	0	0	0	0	1	0	0	0	9797	884	31	1	247	1	MRPL34	19	17417150	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	416202	17417150	41711833	308	3147										
ZNF429	353088	broad.mit.edu	37	chr19	21719683	21719683	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcaacccttactacccataaGagaattcattctggagagaa	6	10	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:21719683G>A	uc002nqd.1	+	4	965	c.828G>A	c.(826-828)AAG>AAA	p.K276K	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	276	C2H2-type 5.			Missing (in Ref. 2; AAP30884 and 3; AAK01422).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTACCCATAAGAGAATTCATT	0.378													0	0	0	0.009096	0	4	35										A	21719683	G	A	21719683	2	1	12	1	0	0	0	0	0	0	0	1	17899	933	33	1		1	ZNF429	19	21719683	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	4302533	21719683	37409300	309	3148										
ZNF91	7644	broad.mit.edu	37	chr19	23545301	23545301	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaaaatttatagaagactttCaaatatttcccacattgaaa	3	6	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:23545301C>G	uc002nre.2	-	4	593	c.480G>C	c.(478-480)TTG>TTC	p.L160F	ZNF91_uc010xrj.1_Missense_Mutation_p.L128F	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	160	C2H2-type 1; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGAAGACTTTCAAATATTTCC	0.328													0	0	0	0.003163	0	15	51										G	23545301	C	G	23545301	3	3	12	1	0	0	0	0	1	0	0	0	18197	825	29	1	3099	1	ZNF91	19	23545301	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1825618	23545301	35583682	310	3149										
ZNF91	7644	broad.mit.edu	37	chr19	23545372	23545372	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gttaagtttattataaccttCtttgtgcaccttacactcat	4	9	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:23545372C>G	uc002nre.2	-	4	522	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	ZNF91_uc010xrj.1_Missense_Mutation_p.E105Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	137						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTATAACCTTCTTTGTGCACC	0.299													0	0	0	0.005443	0	23	60										G	23545372	C	G	23545372	3	3	12	1	0	0	0	0	1	0	0	0	18197	922	32	1	3170	1	ZNF91	19	23545372	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	71	23545372	35583611	311	3150										
ZNF681	148213	broad.mit.edu	37	chr19	23938261	23938261	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttctgtagttctctaacatCacattcctatataaattctg	3	9	4	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:23938261C>G	uc002nrk.3	-	2	238	c.96G>C	c.(94-96)GTG>GTC	p.V32V	ZNF681_uc002nrl.3_Intron|ZNF681_uc002nrj.3_Intron|ZNF681_uc002nrm.1_5'Flank	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TCTCTAACATCACATTCCTAT	0.358													0	0	0	0.007413	0	17	95										G	23938261	C	G	23938261	2	3	12	1	0	0	0	0	0	0	0	1	18085	813	29	1		1	ZNF681	19	23938261	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	392889	23938261	35190722	312	3151										
TSHZ3	57616	broad.mit.edu	37	chr19	31768941	31768941	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gagaccagggtctggtttttCgtcggggagacaatctcact	13	9	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:31768941C>T	uc002nsy.3	-	2	1823	c.1758G>A	c.(1756-1758)ACG>ACA	p.T586T		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	586					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TCTGGTTTTTCGTCGGGGAGA	0.552													0	0	0	0.012319	0	21	114										T	31768941	C	T	31768941	2	4	12	1	0	0	0	0	0	0	0	1	16622	871	31	1		1	TSHZ3	19	31768941	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	7830680	31768941	27360042	313	3152										
ZNF146	7705	broad.mit.edu	37	chr19	36727471	36727471	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttcacacgagagagaaaccTtttgaatgtaacgagtgtgg	11	6	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:36727471T>G	uc002odq.3	+	4	1652	c.129T>G	c.(127-129)CCT>CCG	p.P43P	ZNF146_uc010eet.2_Silent_p.P43P|ZNF146_uc010eeu.2_Silent_p.P43P	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	43					regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GAGAGAAACCTTTTGAATGTA	0.418													0	0	0	0.01441	0	130	70										G	36727471	T	G	36727471	2	3	12	1	0	0	0	0	0	0	0	1	17730	1596	56	5		5	ZNF146	19	36727471	Silent	SNP	T	TCGA-BT-A20R-01A-12D-A16O-08	4958530	36727471	22401512	314	3153										
ZNF420	147923	broad.mit.edu	37	chr19	37619283	37619283	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtcgtggctcagaacttactCaacatgagcgaattcacaca	8	11	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:37619283C>T	uc002ofl.2	+	5	1605	c.1390C>T	c.(1390-1392)CAA>TAA	p.Q464*		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	464	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGAACTTACTCAACATGAGCG	0.423													0	0	0	0.009096	0	4	80										T	37619283	C	T	37619283	4	4	12	1	0	0	0	0	0	1	0	0	17894	827	29	1	1400	1	ZNF420	19	37619283	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	891812	37619283	21509700	315	3154										
SIPA1L3	23094	broad.mit.edu	37	chr19	38610501	38610501	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggttctgtggaggacataagGgagatagtgcagagactgaa	16	4	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:38610501G>A	uc002ohk.2	+	9	3356	c.2847G>A	c.(2845-2847)AGG>AGA	p.R949R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	949					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGACATAAGGGAGATAGTGC	0.532													0	0	0	0.00308	0	7	115										A	38610501	G	A	38610501	2	1	12	1	0	0	0	0	0	0	0	1	14331	1223	43	2		2	SIPA1L3	19	38610501	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	991218	38610501	20518482	316	3155										
EID2	163126	broad.mit.edu	37	chr19	40030401	40030401	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccccagcaagcgggcgacctCcgccatccgggcttccctgg	12	19	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:40030401C>T	uc002oma.2	-	1	438	c.319G>A	c.(319-321)GAG>AAG	p.E107K		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	107	Ala-rich.				cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CGGGCGACCTCCGCCATCCGG	0.418													0	0	0	0.001168	0	6	90										T	40030401	C	T	40030401	3	4	12	1	0	0	0	0	1	0	0	0	4987	864	30	1	395	1	EID2	19	40030401	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1419900	40030401	19098582	317	3156										
ZNF574	64763	broad.mit.edu	37	chr19	42584035	42584035	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tctgcccacaacaccagtccCaccagaggaacctgtcattg	7	16	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:42584035C>T	uc002osm.3	+	2	1446	c.1277C>T	c.(1276-1278)CCA>CTA	p.P426L	ZNF574_uc002osk.3_Missense_Mutation_p.P516L	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	426	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				ACACCAGTCCCACCAGAGGAA	0.587													0	0	0	0.008291	0	10	168										T	42584035	C	T	42584035	3	4	12	1	0	0	0	0	1	0	0	0	18003	594	21	2	1279	2	ZNF574	19	42584035	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2553634	42584035	16544948	318	3157										
ZNF45	7596	broad.mit.edu	37	chr19	44417605	44417605	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcaccctcatcatcagcatgGactcgctgatgaatgataag	8	11	4	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:44417605G>C	uc002oxu.1	-	4	2082	c.1983C>G	c.(1981-1983)GTC>GTG	p.V661V	ZNF45_uc002oxw.1_Silent_p.V661V|ZNF45_uc002oxv.1_Silent_p.V661V	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	661	C2H2-type 18.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CATCAGCATGGACTCGCTGAT	0.433													0	0	0	0.013537	0	10	94										C	44417605	G	C	44417605	2	2	12	1	0	0	0	0	0	0	0	1	17918	1161	41	1		1	ZNF45	19	44417605	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1833570	44417605	14711378	319	3158										
ZNF45	7596	broad.mit.edu	37	chr19	44418218	44418218	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tttgatgggccagaagatttGaggcctggctgaagcccttg	14	8	0	5			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:44418218G>C	uc002oxu.1	-	4	1469	c.1370C>G	c.(1369-1371)TCA>TGA	p.S457*	ZNF45_uc002oxw.1_Nonsense_Mutation_p.S457*|ZNF45_uc002oxv.1_Nonsense_Mutation_p.S457*	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	457	C2H2-type 11.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CAGAAGATTTGAGGCCTGGCT	0.473													0	0	0	0.001168	0	5	125										C	44418218	G	C	44418218	4	2	12	1	0	0	0	0	0	1	0	0	17918	1294	45	1	682	1	ZNF45	19	44418218	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	613	44418218	14710765	320	3159										
ZNF223	7766	broad.mit.edu	37	chr19	44571040	44571040	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aaagaatgtgggaagagcttCagacggtcctcctatctttt	10	8	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:44571040C>T	uc002oyf.1	+	5	1312	c.1059C>T	c.(1057-1059)TTC>TTT	p.F353F	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	353	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				GGAAGAGCTTCAGACGGTCCT	0.433													0	0	0	0.006122	0	17	140										T	44571040	C	T	44571040	2	4	12	1	0	0	0	0	0	0	0	1	17774	825	29	1		1	ZNF223	19	44571040	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	152822	44571040	14557943	321	3160										
TNNT1	7138	broad.mit.edu	37	chr19	55652318	55652318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gttgctcggctctctctgacCggcgccgctcctgggaaacg	13	15	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:55652318C>T	uc002qjb.3	-	9	409	c.320G>A	c.(319-321)CGG>CAG	p.R107Q	TNNT1_uc002qiz.3_Missense_Mutation_p.R37Q|TNNT1_uc002qja.3_Missense_Mutation_p.R37Q|TNNT1_uc002qjc.3_Missense_Mutation_p.R107Q|TNNT1_uc002qje.3_Missense_Mutation_p.R96Q|TNNT1_uc002qjd.3_Missense_Mutation_p.R96Q|TNNT1_uc002qjf.2_Missense_Mutation_p.R103Q	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	107					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		TCTCTCTGACCGGCGCCGCTC	0.602											OREG0025677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	36										T	55652318	C	T	55652318	3	4	12	1	0	0	0	0	1	0	0	0	16327	652	23	2	540	2	TNNT1	19	55652318	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	11081278	55652318	3476665	322	3161										
ZNF587	84914	broad.mit.edu	37	chr19	58371385	58371385	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ttttctgaatgttccagtctCattaaacacaggagaattca	6	8	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:58371385C>T	uc002qql.2	+	3	1743	c.1605C>T	c.(1603-1605)CTC>CTT	p.L535L	ZNF587_uc002qqb.2_Silent_p.L492L|ZNF587_uc010yhh.1_Silent_p.L492L|ZNF587_uc002qqi.1_Silent_p.L492L|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Silent_p.L534L	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	535	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		GTTCCAGTCTCATTAAACACA	0.403													0	0	0	0.00499	0	16	89										T	58371385	C	T	58371385	2	4	12	1	0	0	0	0	0	0	0	1	18017	813	29	1		1	ZNF587	19	58371385	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	2719067	58371385	757598	323	3162										
ZNF329	79673	broad.mit.edu	37	chr19	58640693	58640693	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	atattcacaaattgcttcctGagtccctggtttctccagag	7	11	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:58640693G>C	uc002qrn.2	-	4	415	c.178C>G	c.(178-180)CAG>GAG	p.Q60E	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	60					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		ATTGCTTCCTGAGTCCCTGGT	0.488													0	0	0	0.004672	0	3	120										C	58640693	G	C	58640693	3	2	12	1	0	0	0	0	1	0	0	0	17844	1299	45	1	1451	1	ZNF329	19	58640693	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	269308	58640693	488290	324	3163										
CHMP2A	27243	broad.mit.edu	37	chr19	59063309	59063309	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	taggctaagtcccagctcatCcagaacctgggacaccacag	9	14	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr19:59063309C>G	uc002qti.2	-	4	931	c.505G>C	c.(505-507)GAT>CAT	p.D169H	CHMP2A_uc002qtj.2_Missense_Mutation_p.D169H|CHMP2A_uc002qtk.2_Missense_Mutation_p.D169H	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	169	Interaction with VPS4B.			DE->AA: Diminishes interaction with VPS4B.	cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCAGCTCATCCAGAACCTGG	0.577													0	0	0	0.008871	0	21	44										G	59063309	C	G	59063309	3	3	12	1	0	0	0	0	1	0	0	0	3354	855	30	1	171	1	CHMP2A	19	59063309	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	422616	59063309	65674	325	3164										
C20orf12	55184	broad.mit.edu	37	chr20	18374906	18374906	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ggaataactcaccccagctgGacctgctgccgcacagcccc	9	18	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:18374906G>C	uc010zsa.1	-	16	1966	c.1757C>G	c.(1756-1758)TCC>TGC	p.S586C	C20orf12_uc010zrz.1_Missense_Mutation_p.S105C|C20orf12_uc002wqp.3_Missense_Mutation_p.S277C|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.S453C|C20orf12_uc002wqq.3_Missense_Mutation_p.S567C	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	394						intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				ACCCCAGCTGGACCTGCTGCC	0.512													0	0	0	0.008291	0	10	17										C	18374906	G	C	18374906	3	2	12	1	0	0	0	0	1	0	0	0	2085	1174	41	1	582	1	C20orf12	20	18374906	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		18374906	44650614	326	3165										
SLC32A1	140679	broad.mit.edu	37	chr20	37357240	37357240	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tccggcttcgtgcactccctCgagggcctcatcgaagccta	10	16	1	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:37357240C>G	uc002xjc.2	+	2	1799	c.1536C>G	c.(1534-1536)CTC>CTG	p.L512L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	512	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGCACTCCCTCGAGGGCCTCA	0.667													0	0	0	0.004672	0	3	29										G	37357240	C	G	37357240	2	3	12	1	0	0	0	0	0	0	0	1	14565	871	31	1		1	SLC32A1	20	37357240	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	18982334	37357240	25668280	327	3166										
DPM1	8813	broad.mit.edu	37	chr20	49574949	49574949	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	cacgatgagcggcaggttctCgcgctcgttgtaggtaggta	15	9	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr20:49574949C>G	uc002xvw.1	-	1	112	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	DPM1_uc002xvx.1_RNA|MOCS3_uc002xvy.1_5'Flank	NM_003859	NP_003850	O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase 1	38					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			ovary(1)	1						GGCAGGTTCTCGCGCTCGTTG	0.582													0	0	0	0.004007	0	16	25										G	49574949	C	G	49574949	3	3	12	1	0	0	0	0	1	0	0	0	4724	893	31	1	706	1	DPM1	20	49574949	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	12217709	49574949	13450571	328	3167										
RBM11	54033	broad.mit.edu	37	chr21	15588577	15588577	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tagaggcccgagttcgggaaGagattctgtacgagctgttc	14	8	1	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr21:15588577G>A	uc002yjo.3	+	1	112	c.70G>A	c.(70-72)GAG>AAG	p.E24K	RBM11_uc002yjn.3_5'UTR|RBM11_uc002yjp.3_5'UTR	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	24	RRM.						nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		AGTTCGGGAAGAGATTCTGTA	0.612													0	0	0	0.004672	0	3	24										A	15588577	G	A	15588577	3	1	12	1	0	0	0	0	1	0	0	0	13112	943	33	1	72	1	RBM11	21	15588577	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08		15588577	32541318	329	3168										
TRPM2	7226	broad.mit.edu	37	chr21	45817728	45817728	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agctcggaggagatgctggcGctggcggaggagtatgagca	19	7	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr21:45817728G>A	uc002zet.1	+	14	2244	c.2031G>A	c.(2029-2031)GCG>GCA	p.A677A	TRPM2_uc002zeu.1_Silent_p.A677A|TRPM2_uc002zew.1_Silent_p.A677A|TRPM2_uc010gpt.1_Silent_p.A677A|TRPM2_uc002zex.1_Silent_p.A463A|TRPM2_uc002zey.1_Silent_p.A190A	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	677	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGATGCTGGCGCTGGCGGAGG	0.642													0	0	0	0.006214	0	10	20										A	45817728	G	A	45817728	2	1	12	1	0	0	0	0	0	0	0	1	16583	1074	38	2		2	TRPM2	21	45817728	Silent	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	30229151	45817728	2312167	330	3169										
LRRC3	81543	broad.mit.edu	37	chr21	45876666	45876666	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgaccacgcaggggctgtgGctgtcttctgcagcttgcgg	15	12	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr21:45876666G>A	uc002zfa.2	+	2	432	c.139G>A	c.(139-141)GCT>ACT	p.A47T		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	47	LRRNT.					integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		AGGGGCTGTGGCTGTCTTCTG	0.667													0	0	0	0.001984	0	7	34										A	45876666	G	A	45876666	3	1	12	1	0	0	0	0	1	0	0	0	8984	1203	42	2	141	2	LRRC3	21	45876666	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	58938	45876666	2253229	331	3170										
CYTSA	23384	broad.mit.edu	37	chr22	24759250	24759250	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gcatctgttaagaacatcttCagccagccggcctgcttccc	8	15	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:24759250C>A	uc002zzw.2	+	12	3072	c.2765C>A	c.(2764-2766)TCA>TAA	p.S922*	CYTSA_uc002zzv.3_Nonsense_Mutation_p.S922*|CYTSA_uc011ajq.1_Nonsense_Mutation_p.S922*	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	922					cell cycle|cell division						0						AGAACATCTTCAGCCAGCCGG	0.403													1	0	1.5739e-10	0.004007	1.69887e-10	16	16										A	24759250	C	A	24759250	4	1	12	1	0	0	0	0	0	1	0	0	4209	838	29	3	2803	3	CYTSA	22	24759250	Nonsense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		24759250	26545316	332	3171										
RFPL1	5988	broad.mit.edu	37	chr22	29834919	29834919	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gtcccgtctgctcagactatCtagagaaaccaatgtccctg	8	13	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:29834919C>G	uc003afn.2	+	1	348	c.139C>G	c.(139-141)CTA>GTA	p.L47V	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	47	RING-type.						zinc ion binding				0						CTCAGACTATCTAGAGAAACC	0.517													0	0	0	0.001855	0	14	74										G	29834919	C	G	29834919	3	3	12	1	0	0	0	0	1	0	0	0	13253	912	32	1	141	1	RFPL1	22	29834919	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	5075669	29834919	21469647	333	3172										
RFPL1	5988	broad.mit.edu	37	chr22	29835036	29835036	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gttgctgttccatggtctctCagaagaacaaaatcaggccc	9	11	3	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:29835036C>G	uc003afn.2	+	1	465	c.256C>G	c.(256-258)CAG>GAG	p.Q86E	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	86							zinc ion binding				0						CATGGTCTCTCAGAAGAACAA	0.522													0	0	0	0.010729	0	9	111										G	29835036	C	G	29835036	3	3	12	1	0	0	0	0	1	0	0	0	13253	827	29	1	258	1	RFPL1	22	29835036	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	117	29835036	21469530	334	3173										
OSBP2	23762	broad.mit.edu	37	chr22	31289134	31289134	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ccaccaccccccctcagctgCgcactacgtgttctccaagc	6	21	2	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:31289134C>T	uc003aiy.1	+	9	1999	c.1895C>T	c.(1894-1896)GCG>GTG	p.A632V	OSBP2_uc011ala.1_Missense_Mutation_p.A466V|OSBP2_uc010gwc.1_Missense_Mutation_p.A459V|OSBP2_uc011alb.1_Missense_Mutation_p.A583V|OSBP2_uc003aiz.1_Missense_Mutation_p.A631V|OSBP2_uc003aja.1_Missense_Mutation_p.A265V|OSBP2_uc011alc.1_Missense_Mutation_p.A374V|OSBP2_uc003ajb.2_Missense_Mutation_p.A177V|OSBP2_uc011ald.1_Missense_Mutation_p.A176V|OSBP2_uc010gwd.1_Missense_Mutation_p.A177V	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	632					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						CCCTCAGCTGCGCACTACGTG	0.592													0	0	0	0.000602	0	5	27										T	31289134	C	T	31289134	3	4	12	1	0	0	0	0	1	0	0	0	11274	768	27	2	1929	2	OSBP2	22	31289134	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	1454098	31289134	20015432	335	3174										
GGA1	26088	broad.mit.edu	37	chr22	38021890	38021890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctatgcccacccgccctggcGagcaggccagccctgagcag	12	18	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:38021890G>A	uc003atc.2	+	11	1392	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K	GGA1_uc003atd.2_Intron|GGA1_uc003ate.2_Missense_Mutation_p.E343K|GGA1_uc003atf.2_Missense_Mutation_p.E270K	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	343	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					CCGCCCTGGCGAGCAGGCCAG	0.687													0	0	0	0.013537	0	12	43										A	38021890	G	A	38021890	3	1	12	1	0	0	0	0	1	0	0	0	6352	1059	37	1	1135	1	GGA1	22	38021890	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	6732756	38021890	13282676	336	3175										
CELSR1	9620	broad.mit.edu	37	chr22	46929664	46929664	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aggtgtagttgaggctgtctGacacgtcggggtcatgggcc	17	8	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chr22:46929664G>C	uc003bhw.1	-	1	3404	c.3404C>G	c.(3403-3405)TCA>TGA	p.S1135*		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1135	Extracellular (Potential).|Cadherin 9.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GAGGCTGTCTGACACGTCGGG	0.617													0	0	0	0.001984	0	6	75										C	46929664	G	C	46929664	4	2	12	1	0	0	0	0	0	1	0	0	3221	1294	45	1	5780	1	CELSR1	22	46929664	Nonsense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8907774	46929664	4374902	337	3176										
PHEX	5251	broad.mit.edu	37	chrX	22056609	22056609	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agtcaaggtctcttaagtctCcaagctaaacaggagtactg	9	9	3	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:22056609C>T	uc004dah.2	+	2	344	c.141C>T	c.(139-141)CTC>CTT	p.L47L	PHEX_uc011mjr.1_Silent_p.L47L|PHEX_uc011mjs.1_5'UTR	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	47	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						TCTTAAGTCTCCAAGCTAAAC	0.453													0	0	0	0.007835	0	40	176										T	22056609	C	T	22056609	2	4	12	1	0	0	0	0	0	0	0	1	11819	842	30	1		1	PHEX	23	22056609	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08		22056609	133213951	338	3177										
PTCHD1	139411	broad.mit.edu	37	chrX	23412194	23412194	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	actttcctgccaccctctaaGaaaaaaaggaaagagaagaa	7	9	1	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:23412194G>C	uc004dal.3	+	3	2567	c.2559G>C	c.(2557-2559)AAG>AAC	p.K853N		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	853					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CACCCTCTAAGAAAAAAAGGA	0.403													0	0	0	0.00623	0	38	78										C	23412194	G	C	23412194	3	2	12	1	0	0	0	0	1	0	0	0	12732	933	33	1	2569	1	PTCHD1	23	23412194	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	1355585	23412194	131858366	339	3178										
FAM47C	442444	broad.mit.edu	37	chrX	37029100	37029100	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	aatccatcagcagtctgtttGactttacccctgagtgcaga	8	11	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:37029100G>C	uc004ddl.1	+	1	2631	c.2617G>C	c.(2617-2619)GAC>CAC	p.D873H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	873										ovary(3)	3						CAGTCTGTTTGACTTTACCCC	0.458													0	0	0	0.004482	0	8	133										C	37029100	G	C	37029100	3	2	12	1	0	0	0	0	1	0	0	0	5571	1290	45	1	2619	1	FAM47C	23	37029100	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13616906	37029100	118241460	340	3179										
RPGR	6103	broad.mit.edu	37	chrX	38150241	38150241	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctgaactggtgataattttaAtgacttttcattggaattca	7	5	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:38150241A>C	uc004ded.1	-	13	1711	c.1543T>G	c.(1543-1545)TTA>GTA	p.L515V	RPGR_uc004deb.2_Missense_Mutation_p.L515V|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	515					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GATAATTTTAATGACTTTTCA	0.229													0	0	0	0.001984	0	6	30										C	38150241	A	C	38150241	3	2	12	1	0	0	0	0	1	0	0	0	13548	98	4	5	2486	5	RPGR	23	38150241	Missense_Mutation	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	1121141	38150241	117120319	341	3180										
PHF16	9767	broad.mit.edu	37	chrX	46884244	46884244	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tcatggagttggcagcatctGtttgccgctatgacctagat	11	9	2	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:46884244G>C	uc004dgx.2	+	5	454	c.403G>C	c.(403-405)GTT>CTT	p.V135L	PHF16_uc004dgy.2_Missense_Mutation_p.V135L	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	135					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						GGCAGCATCTGTTTGCCGCTA	0.468													0	0	0	0.007413	0	18	52										C	46884244	G	C	46884244	3	2	12	1	0	0	0	0	1	0	0	0	11827	1377	48	4	417	4	PHF16	23	46884244	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8734003	46884244	108386316	342	3181										
RRAGB	10325	broad.mit.edu	37	chrX	55755751	55755751	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgtagaacattctcatgttcGatttctgggaaacctggtat	9	7	2	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:55755751G>T	uc004dup.2	+	5	986	c.335G>T	c.(334-336)CGA>CTA	p.R112L	RRAGB_uc004duq.2_Missense_Mutation_p.R84L	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	112					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						TCTCATGTTCGATTTCTGGGA	0.388													1	0	1.22574e-08	0.014323	1.31653e-08	22	62										T	55755751	G	T	55755751	3	4	12	1	0	0	0	0	1	0	0	0	13673	1058	37	3	353	3	RRAGB	23	55755751	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	8871507	55755751	99514809	343	3182										
GDPD2	54857	broad.mit.edu	37	chrX	69646848	69646848	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gcctgggctggtgggacaccGaggggcccccatggtgagtg	19	11	0	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:69646848G>A	uc004dyh.2	+	8	940	c.689G>A	c.(688-690)CGA>CAA	p.R230Q	GDPD2_uc010nkx.1_Missense_Mutation_p.R230Q|GDPD2_uc010nky.1_Missense_Mutation_p.R16Q|GDPD2_uc011mpk.1_Missense_Mutation_p.R230Q|GDPD2_uc011mpl.1_Missense_Mutation_p.R151Q|GDPD2_uc011mpm.1_Missense_Mutation_p.R151Q	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	230	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					GTGGGACACCGAGGGGCCCCC	0.612													0	0	0	0.001984	0	7	34										A	69646848	G	A	69646848	3	1	12	1	0	0	0	0	1	0	0	0	6324	1058	37	1	715	1	GDPD2	23	69646848	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	13891097	69646848	85623712	344	3183										
FOXO4	4303	broad.mit.edu	37	chrX	70321316	70321316	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	agtaagctggccacgggcgtCggcctgtgtcccaagcccct	13	15	0	0			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:70321316C>A	uc004dys.1	+	2	1589	c.1236C>A	c.(1234-1236)GTC>GTA	p.V412V	FOXO4_uc010nkz.2_Intron|FOXO4_uc004dyt.1_Silent_p.V357V	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	412					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)					CCACGGGCGTCGGCCTGTGTC	0.617													1	0	0.00116845	0.001168	0.00121888	6	29										A	70321316	C	A	70321316	2	1	12	1	0	0	0	0	0	0	0	1	6025	871	31	3		3	FOXO4	23	70321316	Silent	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	674468	70321316	84949244	345	3184										
MED12	9968	broad.mit.edu	37	chrX	70338701	70338701	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ctcaggaccccaaacagaagGaggtgcgttcgaaaatcggg	13	10	1	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:70338701G>A	uc004dyy.2	+	1	296	c.97G>A	c.(97-99)GAG>AAG	p.E33K	MED12_uc011mpq.1_Missense_Mutation_p.E33K|MED12_uc004dyz.2_Missense_Mutation_p.E33K|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	33					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CAAACAGAAGGAGGTGCGTTC	0.677													0	0	0	0.001168	0	5	9										A	70338701	G	A	70338701	3	1	12	1	0	0	0	0	1	0	0	0	9428	1175	41	1	99	1	MED12	23	70338701	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	17385	70338701	84931859	346	3185										
GPRASP2	114928	broad.mit.edu	37	chrX	101970821	101970821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	ataagcagtcctgggttttgCctggagaagaggccaatagt	13	7	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:101970821C>T	uc004ejk.2	+	4	2358	c.1024C>T	c.(1024-1026)CCT>TCT	p.P342S	GPRASP2_uc004ejl.2_Missense_Mutation_p.P342S|GPRASP2_uc004ejm.2_Missense_Mutation_p.P342S|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	342						cytoplasm	protein binding			ovary(1)	1						CTGGGTTTTGCCTGGAGAAGA	0.448													0	0	0	0.009096	0	4	116										T	101970821	C	T	101970821	3	4	12	1	0	0	0	0	1	0	0	0	6723	739	26	2	1026	2	GPRASP2	23	101970821	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	31632120	101970821	53299739	347	3186										
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011463	105011463	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gttgcagaggttataaacatGagataccagccacgaccttg	10	9	0	2			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:105011463G>C	uc004elz.1	+	11	2626	c.1870G>C	c.(1870-1872)GAG>CAG	p.E624Q		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	624	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TTATAAACATGAGATACCAGC	0.478													0	0	0	0.004482	0	9	118										C	105011463	G	C	105011463	3	2	12	1	0	0	0	0	1	0	0	0	7662	1291	45	1	1908	1	IL1RAPL2	23	105011463	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	3040642	105011463	50259097	348	3187										
RBMX2	51634	broad.mit.edu	37	chrX	129545341	129545341	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	gatcaaaggaagaactatccGagtggatcatgtgtctaact	10	7	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:129545341G>A	uc004evt.2	+	5	387	c.323G>A	c.(322-324)CGA>CAA	p.R108Q		NM_016024	NP_057108	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	108	RRM.						nucleotide binding|RNA binding			breast(3)|ovary(1)	4						AGAACTATCCGAGTGGATCAT	0.478													0	0	0	0.00308	0	8	89										A	129545341	G	A	129545341	3	1	12	1	0	0	0	0	1	0	0	0	13152	1058	37	1	341	1	RBMX2	23	129545341	Missense_Mutation	SNP	G	TCGA-BT-A20R-01A-12D-A16O-08	24533878	129545341	25725219	349	3188										
GPR50	9248	broad.mit.edu	37	chrX	150349383	150349383	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgtctaccctaagcctgcctCtgtccatttcaaggctgact	7	14	3	1			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:150349383C>G	uc010ntg.1	+	2	1463	c.1328C>G	c.(1327-1329)TCT>TGT	p.S443C		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	443	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCCTGCCTCTGTCCATTTC	0.557													0	0	0	0.00308	0	8	371										G	150349383	C	G	150349383	3	3	12	1	0	0	0	0	1	0	0	0	6697	913	32	1	1334	1	GPR50	23	150349383	Missense_Mutation	SNP	C	TCGA-BT-A20R-01A-12D-A16O-08	20804042	150349383	4921177	350	3189										
PNMA5	114824	broad.mit.edu	37	chrX	152159943	152159943	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.501432664756447	175	4.51869049339446e-60	3.78546700237254	5.04316910030366	2.80725425953722	0.00349382951186429	0.0143845523918265	129	tgacagtgtcagccagttcaAtgaagactgccttggcattg	11	9	2	3			TCGA-BT-A20R-01A-12D-A16O-08	TCGA-BT-A20R-11A-11D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9bbbfc3-0beb-4f91-92a1-081bff7c4a07	2c9954e9-6225-4fe3-b749-4812dd7cbe26	g.chrX:152159943A>G	uc010ntw.2	-	3	539	c.200T>C	c.(199-201)ATT>ACT	p.I67T	PNMA5_uc004fha.3_Missense_Mutation_p.I67T|PNMA5_uc010ntx.2_Missense_Mutation_p.I67T|PNMA5_uc004fgy.3_Missense_Mutation_p.I67T	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	67					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					agccagttcaatgaagactgc	0													0	0	0	0.00632	0	29	117										G	152159943	A	G	152159943	3	3	12	1	0	0	0	0	1	0	0	0	12156	101	4	5	1150	5	PNMA5	23	152159943	Missense_Mutation	SNP	A	TCGA-BT-A20R-01A-12D-A16O-08	1810560	152159943	3110617	351	3190										
AGRN	375790	broad.mit.edu	37	chr1	957838	957838	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaggaggtggagttctgtgtGgaaggtgcgtggtggggggc	24	3	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:957838G>A	uc001ack.1	+	2	509	c.459G>A	c.(457-459)GTG>GTA	p.V153V		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	153	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		AGTTCTGTGTGGAAGGTGCGT	0.657													0	0	0	0.014323	0	23	30										A	957838	G	A	957838	2	1	13	1	0	0	0	0	0	0	0	1	397	1335	47	2		2	AGRN	1	957838	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		957838	248292783	1	3191										
DFFB	1677	broad.mit.edu	37	chr1	3800260	3800260	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccaagcagaatctacaaaccCcagacaaggttgaagcggaa	9	11	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:3800260C>T	uc001alc.2	+	7	1295	c.972C>T	c.(970-972)CCC>CCT	p.P324P	DFFB_uc001ale.2_RNA|DFFB_uc009vlp.2_RNA|DFFB_uc001alb.2_RNA|DFFB_uc010nzn.1_Silent_p.P348P|DFFB_uc009vlq.2_RNA|DFFB_uc009vlr.2_Silent_p.P275P|DFFB_uc001ald.2_Silent_p.P260P	NM_004402	NP_004393	O76075	DFFB_HUMAN	DNA fragmentation factor, 40 kD, beta	324					apoptotic chromosome condensation|DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction	cytosol|nucleoplasm	deoxyribonuclease activity|enzyme binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;2.05e-30)|all_epithelial(116;6.22e-21)|all_lung(118;2.65e-08)|Lung NSC(185;6.25e-06)|Breast(487;0.000659)|Renal(390;0.00121)|all_neural(13;0.0019)|Hepatocellular(190;0.00705)|Colorectal(325;0.0113)|all_hematologic(16;0.0194)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0548)|Medulloblastoma(700;0.211)		Epithelial(90;1.18e-39)|OV - Ovarian serous cystadenocarcinoma(86;7.28e-23)|GBM - Glioblastoma multiforme(42;2.95e-17)|Colorectal(212;1.23e-05)|COAD - Colon adenocarcinoma(227;5.94e-05)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00038)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		TCTACAAACCCCAGACAAGGT	0.498													0	0	0	0.027356	0	28	65										T	3800260	C	T	3800260	2	4	13	1	0	0	0	0	0	0	0	1	4453	610	22	2		2	DFFB	1	3800260	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2842422	3800260	245450361	2	3192										
LOC440563	440563	broad.mit.edu	37	chr1	13183388	13183388	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atccccgctttccactcttaGaattgaagccacttttgccc	5	15	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:13183388G>C	uc010obg.1	-	1	580	c.485C>G	c.(484-486)TCT>TGT	p.S162C		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	162						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						TCCACTCTTAGAATTGAAGCC	0.502													0	0	0	0.01441	0	79	496										C	13183388	G	C	13183388	3	2	13	1	0	0	0	0	1	0	0	0	8879	942	33	1	400	1	LOC440563	1	13183388	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	9383128	13183388	236067233	3	3193										
EIF4G3	8672	broad.mit.edu	37	chr1	21226289	21226289	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aacactctcagcaccattacGtactggctcagcttcttctc	5	15	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:21226289G>A	uc001bec.2	-	11	1988	c.1732C>T	c.(1732-1734)CGT>TGT	p.R578C	EIF4G3_uc010odi.1_Missense_Mutation_p.R182C|EIF4G3_uc010odj.1_Missense_Mutation_p.R577C|EIF4G3_uc009vpz.2_Missense_Mutation_p.R298C|EIF4G3_uc001bed.2_Missense_Mutation_p.R578C|EIF4G3_uc001bef.2_Missense_Mutation_p.R577C|EIF4G3_uc001bee.2_Missense_Mutation_p.R584C	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	578					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GCACCATTACGTACTGGCTCA	0.438													0	0	0	0.020292	0	15	271										A	21226289	G	A	21226289	3	1	13	1	0	0	0	0	1	0	0	0	5038	1145	40	2	3113	2	EIF4G3	1	21226289	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	8042901	21226289	228024332	4	3194										
PUM1	9698	broad.mit.edu	37	chr1	31478834	31478834	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	actgttcacatggaaactctGaccaggtcttctctgcacca	7	13	4	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:31478834G>C	uc001bsi.1	-	5	699	c.586C>G	c.(586-588)CAG>GAG	p.Q196E	PUM1_uc001bsg.1_Missense_Mutation_p.Q8E|PUM1_uc001bsh.1_Missense_Mutation_p.Q196E|PUM1_uc001bsj.1_Missense_Mutation_p.Q196E|PUM1_uc010oga.1_Intron|PUM1_uc001bsk.1_Missense_Mutation_p.Q232E|PUM1_uc010ogb.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	196					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGGAAACTCTGACCAGGTCTT	0.468													0	0	0	0.006214	0	10	36										C	31478834	G	C	31478834	3	2	13	1	0	0	0	0	1	0	0	0	12825	1299	45	1	3052	1	PUM1	1	31478834	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	10252545	31478834	217771787	5	3195										
GJA9	81025	broad.mit.edu	37	chr1	39341511	39341511	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccatgtagaccagggatggtGaagacacaaatatcacctgc	10	10	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:39341511G>A	uc001cct.1	-	2	541	c.260C>T	c.(259-261)TCA>TTA	p.S87L	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	87	Helical; (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CAGGGATGGTGAAGACACAAA	0.473													0	0	0	0.01441	0	45	114										A	39341511	G	A	39341511	3	1	13	1	0	0	0	0	1	0	0	0	6406	1294	45	1	1291	1	GJA9	1	39341511	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	7862677	39341511	209909110	6	3196										
MAGOH	4116	broad.mit.edu	37	chr1	53699276	53699276	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctctttggtaatttcactgtCgtcaattattctcttcagtt	5	9	5	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:53699276C>T	uc001cvf.1	-	3	284	c.196G>A	c.(196-198)GAC>AAC	p.D66N	MAGOH_uc010ont.1_Intron	NM_002370	NP_002361	P61326	MGN_HUMAN	mago-nashi homolog	66				DSE->RSR: Slightly reduced nonsense- mediated decay activity.	mRNA 3'-end processing|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|exon-exon junction complex|nuclear speck	protein binding|RNA binding				0						ATTTCACTGTCGTCAATTATT	0.408													0	0	0	0.01441	0	47	103										T	53699276	C	T	53699276	3	4	13	1	0	0	0	0	1	0	0	0	9194	884	31	1	256	1	MAGOH	1	53699276	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	14357765	53699276	195551345	7	3197										
CACHD1	57685	broad.mit.edu	37	chr1	65145288	65145288	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcactgaaggtgatgaggtGatcacattaaacatgattaa	9	5	2	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:65145288G>A	uc001dbo.1	+	24	3207	c.3102G>A	c.(3100-3102)GTG>GTA	p.V1034V	CACHD1_uc001dbp.1_Silent_p.V789V|CACHD1_uc001dbq.1_Silent_p.V789V|CACHD1_uc010opa.1_Silent_p.V278V	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1085	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						GTGATGAGGTGATCACATTAA	0.493													0	0	0	0.009535	0	31	64										A	65145288	G	A	65145288	2	1	13	1	0	0	0	0	0	0	0	1	2537	1277	45	1		1	CACHD1	1	65145288	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	11446012	65145288	184105333	8	3198										
LRRC7	57554	broad.mit.edu	37	chr1	70488897	70488897	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tggcgattgctgcacaccatGggccaggtgtgatcagcaga	14	10	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:70488897G>A	uc001dep.2	+	15	1550	c.1520G>A	c.(1519-1521)TGG>TAG	p.W507*	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	507						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGCACACCATGGGCCAGGTGT	0.587													0	0	0	0.012319	0	20	34										A	70488897	G	A	70488897	4	1	13	1	0	0	0	0	0	1	0	0	9020	1357	47	2	1578	2	LRRC7	1	70488897	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	5343609	70488897	178761724	9	3199										
ZZZ3	26009	broad.mit.edu	37	chr1	78045314	78045314	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agtagctgttccagctttttCtaagccatacccaagaccaa	6	12	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:78045314C>G	uc001dhq.2	-	10	2457	c.1981_splice	c.e10-1	p.K661_splice	ZZZ3_uc001dhr.2_Splice_Site_p.K167_splice|ZZZ3_uc001dhp.2_Splice_Site_p.K660_splice	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						CCAGCTTTTTCTAAGCCATAC	0.323													0	0	0	0.025465	0	37	70										G	78045314	C	G	78045314	5	3	13	1	0	0	0	0	0	0	1	0	18253	927	32	1	755	1	ZZZ3	1	78045314	Splice_Site	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	7556417	78045314	171205307	10	3200										
PRMT6	55170	broad.mit.edu	37	chr1	107599800	107599800	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aggtggatgccatcgtgagcGagtggatgggctacggactc	17	8	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:107599800G>C	uc010ous.1	+	1	534	c.463G>C	c.(463-465)GAG>CAG	p.E155Q		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	155					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		CATCGTGAGCGAGTGGATGGG	0.652													0	0	0	0.024334	0	23	49										C	107599800	G	C	107599800	3	2	13	1	0	0	0	0	1	0	0	0	12540	1059	37	1	465	1	PRMT6	1	107599800	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	29554486	107599800	141650821	11	3201										
KCNA10	3744	broad.mit.edu	37	chr1	111060995	111060995	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtaataatataggattccatCaaaactgggccggttccgat	9	8	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:111060995C>G	uc001dzt.1	-	1	803	c.415G>C	c.(415-417)GAT>CAT	p.D139H		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	139						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		AGGATTCCATCAAAACTGGGC	0.453													0	0	0	0.008361	0	31	64										G	111060995	C	G	111060995	3	3	13	1	0	0	0	0	1	0	0	0	8002	826	29	1	1124	1	KCNA10	1	111060995	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3461195	111060995	138189626	12	3202										
RSBN1	54665	broad.mit.edu	37	chr1	114310974	114310974	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcgcggggttcactggtccGaggtaggtactggagatttt	15	7	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:114310974G>C	uc001edq.2	-	5	1732	c.1696C>G	c.(1696-1698)CGG>GGG	p.R566G	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	566						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACTGGTCCGAGGTAGGTAC	0.428													0	0	0	0.020292	0	12	63										C	114310974	G	C	114310974	3	2	13	1	0	0	0	0	1	0	0	0	13696	1057	37	1	724	1	RSBN1	1	114310974	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3249979	114310974	134939647	13	3203										
TTF2	8458	broad.mit.edu	37	chr1	117633211	117633211	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	taaagctttctgaagatgaaGagactgtttacaatgtgttt	9	4	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:117633211G>T	uc001egy.2	+	15	2574	c.2554G>T	c.(2554-2556)GAG>TAG	p.E852*		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	852					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TGAAGATGAAGAGACTGTTTA	0.368													1	0	4.35082e-09	0.010504	4.66417e-09	17	51										T	117633211	G	T	117633211	4	4	13	1	0	0	0	0	0	1	0	0	16716	943	33	3	2612	3	TTF2	1	117633211	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3322237	117633211	131617410	14	3204										
TXNIP	10628	broad.mit.edu	37	chr1	145441053	145441054	+	Splice_Site	INS	-	-	GT													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caccaccgacttatactgagINSgtgaggattgtcatctttac							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			-	GT	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:145441053_145441054insGT	uc001enn.3	+	7	1481	c.1140_splice	c.e7+1	p.E380_splice	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Splice_Site_p.E325_splice	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein						cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTTATACTGAGGTGAGGATTGT	0.416																		12	238	---	---								GT	145441054	-	GT	145441053	8	5	13	1	0	1	1	0	0	0	1	0	16800	1014	35	0	1166	0	TXNIP	1	145441053	Splice_Site	INS	-	TCGA-BT-A20T-01A-11D-A14W-08	27807842	145441053	103809568	15	3205										
RPRD2	23248	broad.mit.edu	37	chr1	150443792	150443792	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccaattctgtatctacatatCgaccctttggtctgggcagt	8	11	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:150443792C>T	uc009wlr.2	+	11	2569	c.2368C>T	c.(2368-2370)CGA>TGA	p.R790*	RPRD2_uc010pcc.1_Nonsense_Mutation_p.R764*|RPRD2_uc001eup.3_Nonsense_Mutation_p.R764*	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	790	Ser-rich.						protein binding			ovary(1)	1						ATCTACATATCGACCCTTTGG	0.507													0	0	0	0.028581	0	17	40										T	150443792	C	T	150443792	4	4	13	1	0	0	0	0	0	1	0	0	13617	876	31	1	2410	1	RPRD2	1	150443792	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5002739	150443792	98806829	16	3206										
ASH1L	55870	broad.mit.edu	37	chr1	155491121	155491121	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctgtgcatcagtcaaaccatCatctttcccagcttcgatgt	6	13	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:155491121C>T	uc009wqq.2	-	2	670	c.190G>A	c.(190-192)GAT>AAT	p.D64N	ASH1L_uc001fkt.2_Missense_Mutation_p.D64N|ASH1L_uc009wqr.1_Missense_Mutation_p.D64N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	64					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GTCAAACCATCATCTTTCCCA	0.393													0	0	0	0.01441	0	188	399										T	155491121	C	T	155491121	3	4	13	1	0	0	0	0	1	0	0	0	1041	826	29	1	8812	1	ASH1L	1	155491121	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5047329	155491121	93759500	17	3207										
NES	10763	broad.mit.edu	37	chr1	156641159	156641159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atctgcagactgcggcagctCctgtccctcctcctccagag	9	17	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:156641159C>T	uc001fpq.2	-	4	2954	c.2821G>A	c.(2821-2823)GAG>AAG	p.E941K		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	941	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCGGCAGCTCCTGTCCCTCC	0.547													0	0	0	0.01441	0	105	185										T	156641159	C	T	156641159	3	4	13	1	0	0	0	0	1	0	0	0	10337	864	30	1	2048	1	NES	1	156641159	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1150038	156641159	92609462	18	3208										
CD1D	912	broad.mit.edu	37	chr1	158151886	158151886	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gggaacgcctcaaataacttCttccatgtagcatttcaagg	8	10	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:158151886C>G	uc001frr.2	+	4	892	c.393C>G	c.(391-393)TTC>TTG	p.F131L	CD1D_uc009wsr.1_Missense_Mutation_p.F131L|CD1D_uc009wss.2_Missense_Mutation_p.F131L|CD1D_uc009wst.1_Missense_Mutation_p.F27L	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	131	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CAAATAACTTCTTCCATGTAG	0.498													0	0	0	0.01441	0	104	223										G	158151886	C	G	158151886	3	3	13	1	0	0	0	0	1	0	0	0	2977	912	32	1	403	1	CD1D	1	158151886	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1510727	158151886	91098735	19	3209										
ARHGAP30	257106	broad.mit.edu	37	chr1	161021110	161021121	+	In_Frame_Del	DEL	GGCCAGGGCCAA	GGCCAGGGCCAA	-													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caatgggtcctcacctggggGgccagggccaaggccagggc							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:161021110_161021121delGGCCAGGGCCAA	uc001fxl.2	-	10	1749_1760	c.1403_1414delTTGGCCCTGGCC	c.(1402-1416)CTTGGCCCTGGCCCC>CCC	p.LGPG468del	ARHGAP30_uc001fxk.2_In_Frame_Del_p.LGPG468del|ARHGAP30_uc001fxm.2_In_Frame_Del_p.LGPG314del|ARHGAP30_uc009wtx.2_In_Frame_Del_p.LGPG141del|ARHGAP30_uc001fxn.1_In_Frame_Del_p.LGPG314del	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	468_471					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			TCACCTGGGgggccagggccaaggccagggcc	0.434																		7	64	---	---								-	161021121	GGCCAGGGCCAA	-	161021110	7	5	13	1	0	1	0	1	0	0	0	0	879	1232	43	0	1903	0	ARHGAP30	1	161021110	In_Frame_Del	DEL	GGCCAGGGCCAA	TCGA-BT-A20T-01A-11D-A14W-08	2869224	161021110	88229511	20	3210										
POU2F1	5451	broad.mit.edu	37	chr1	167381395	167381395	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctcttgggaccagccaggtGatggtgacagcatcaggttt	13	10	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:167381395G>A	uc001gec.2	+	15	1848	c.1686G>A	c.(1684-1686)GTG>GTA	p.V562V	POU2F1_uc001ged.2_Silent_p.V560V|POU2F1_uc001gee.2_Silent_p.V562V|POU2F1_uc010plh.1_Silent_p.V499V|POU2F1_uc001gef.2_Silent_p.V574V|POU2F1_uc001geg.2_Silent_p.V460V|POU2F1_uc009wvg.1_RNA	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	562					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						CCAGCCAGGTGATGGTGACAG	0.592													0	0	0	0.013537	0	11	32										A	167381395	G	A	167381395	2	1	13	1	0	0	0	0	0	0	0	1	12271	1277	45	1		1	POU2F1	1	167381395	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6360285	167381395	81869226	21	3211										
ASTN1	460	broad.mit.edu	37	chr1	176903363	176903364	+	Missense_Mutation	DNP	CC	CC	TT													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtaccagatagaacaggactCctcaaagccgtagatagctt							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:176903363_176903364CC>TT	uc001glc.2	-	16	2807_2808	c.2595_2596GG>AA	c.(2593-2598)GAGGAG>GAAAAG	p.E866K	ASTN1_uc001glb.1_Missense_Mutation_p.E866K|ASTN1_uc001gld.1_Missense_Mutation_p.E866K	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	874					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GAACAGGACTCCTCAAAGCCGT	0.52													0	0	0	0.004672	0	9	61										TT	176903364	CC	TT	176903363	3	4	13	1	0	0	0	0	1	0	0	0	1064	864	30	1	1324	1	ASTN1	1	176903363	Missense_Mutation	DNP	CC	TCGA-BT-A20T-01A-11D-A14W-08	9521968	176903363	72347258	22	3212										
NCF2	4688	broad.mit.edu	37	chr1	183542321	183542321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gctgagcaatcccacctaccGtcgccttgcctaggtaatcc	8	16	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:183542321G>A	uc001gqj.3	-	5	883	c.608C>T	c.(607-609)ACG>ATG	p.T203M	NCF2_uc010pod.1_Missense_Mutation_p.T158M|NCF2_uc010poe.1_Intron|NCF2_uc001gqk.3_Missense_Mutation_p.T203M	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	203					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						CCCACCTACCGTCGCCTTGCC	0.572													0	0	0	0.01441	0	90	130										A	183542321	G	A	183542321	3	1	13	1	0	0	0	0	1	0	0	0	10217	1159	40	2	1016	2	NCF2	1	183542321	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6638958	183542321	65708300	23	3213										
C1orf26	54823	broad.mit.edu	37	chr1	185144079	185144079	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaagactaagcaggaagaaaGagaatacctggaaagctccc	11	8	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:185144079G>C	uc001grg.3	+	5	914	c.800G>C	c.(799-801)AGA>ACA	p.R267T	C1orf26_uc001grh.3_Missense_Mutation_p.R267T	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	267											0						CAGGAAGAAAGAGAATACCTG	0.368													0	0	0	0.01441	0	54	88										C	185144079	G	C	185144079	3	2	13	1	0	0	0	0	1	0	0	0	2035	942	33	1	814	1	C1orf26	1	185144079	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1601758	185144079	64106542	24	3214										
CRB1	23418	broad.mit.edu	37	chr1	197390429	197390429	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccacactttcatttgagggcGatggcttcctgtgggtcaaa	11	10	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:197390429G>A	uc001gtz.2	+	6	1606	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	CRB1_uc010poz.1_Missense_Mutation_p.D422N|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.D379N|CRB1_uc010ppb.1_Missense_Mutation_p.D491N|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.D140N	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	491	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATTTGAGGGCGATGGCTTCCT	0.517													0	0	0	0.010818	0	31	47										A	197390429	G	A	197390429	3	1	13	1	0	0	0	0	1	0	0	0	3848	1058	37	1	1493	1	CRB1	1	197390429	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12246350	197390429	51860192	25	3215										
C1orf107	27042	broad.mit.edu	37	chr1	210006542	210006542	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aactgcagatgtagctttatCtgctgaccctgagggaaaag	11	8	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:210006542C>T	uc001hhr.1	+	4	477	c.401C>T	c.(400-402)TCT>TTT	p.S134F	C1orf107_uc009xcu.1_5'UTR	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	134	Glu-rich.				multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GTAGCTTTATCTGCTGACCCT	0.398													0	0	0	0.016522	0	24	40										T	210006542	C	T	210006542	3	4	13	1	0	0	0	0	1	0	0	0	1981	913	32	1	415	1	C1orf107	1	210006542	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	12616113	210006542	39244079	26	3216										
ESRRG	2104	broad.mit.edu	37	chr1	216850784	216850784	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttccgtcttgatgaaggacgAacagctggaatcaatgtgtc	11	8	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:216850784A>G	uc001hkw.1	-	2	272	c.106T>C	c.(106-108)TCG>CCG	p.S36P	ESRRG_uc001hky.1_Missense_Mutation_p.S13P|ESRRG_uc009xdp.1_Missense_Mutation_p.S13P|ESRRG_uc001hkz.1_Missense_Mutation_p.S13P|ESRRG_uc010puc.1_Missense_Mutation_p.S13P|ESRRG_uc001hla.1_Missense_Mutation_p.S13P|ESRRG_uc001hlb.1_Missense_Mutation_p.S13P|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Missense_Mutation_p.S13P|ESRRG_uc001hld.1_Missense_Mutation_p.S13P|ESRRG_uc001hkx.1_Missense_Mutation_p.S41P|ESRRG_uc009xdo.1_Missense_Mutation_p.S13P|ESRRG_uc001hle.1_Missense_Mutation_p.S13P	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	36					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	ATGAAGGACGAACAGCTGGAA	0.438													0	0	0	0.007291	0	29	32										G	216850784	A	G	216850784	3	3	13	1	0	0	0	0	1	0	0	0	5262	246	9	5	1294	5	ESRRG	1	216850784	Missense_Mutation	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	6844242	216850784	32399837	27	3217										
MARK1	4139	broad.mit.edu	37	chr1	220825393	220825393	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgtggcctctgctgtcccctCagcacgaccccgccaccaga	9	19	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:220825393C>T	uc001hmn.3	+	15	2234	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	MARK1_uc009xdw.2_Missense_Mutation_p.S546L|MARK1_uc010pun.1_Missense_Mutation_p.S546L|MARK1_uc001hmm.3_Missense_Mutation_p.S524L	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	546					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		GCTGTCCCCTCAGCACGACCC	0.517													0	0	0	0.017118	0	34	66										T	220825393	C	T	220825393	3	4	13	1	0	0	0	0	1	0	0	0	9312	838	29	1	1695	1	MARK1	1	220825393	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3974609	220825393	28425228	28	3218										
RYR2	6262	broad.mit.edu	37	chr1	237875065	237875065	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aatttcaaaagagaagagcaGaacttcgttgtacagaatga	9	5	1	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:237875065G>C	uc001hyl.1	+	71	10371	c.10251G>C	c.(10249-10251)CAG>CAC	p.Q3417H	RYR2_uc010pxz.1_Missense_Mutation_p.Q372H	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3417					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGAAGAGCAGAACTTCGTTG	0.328													0	0	0	0.004672	0	3	26										C	237875065	G	C	237875065	3	2	13	1	0	0	0	0	1	0	0	0	13769	933	33	1	10533	1	RYR2	1	237875065	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	17049672	237875065	11375556	29	3219										
RGS7	6000	broad.mit.edu	37	chr1	240990424	240990424	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgttttgtgggggtttctcaTtctggatgacttcttaatgt	11	5	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:240990424T>A	uc001hyv.2	-	10	988	c.658A>T	c.(658-660)ATG>TTG	p.M220L	RGS7_uc010pyh.1_Missense_Mutation_p.M194L|RGS7_uc010pyj.1_Missense_Mutation_p.M136L|RGS7_uc001hyu.2_Missense_Mutation_p.M220L|RGS7_uc009xgn.1_Missense_Mutation_p.M167L|RGS7_uc001hyw.2_Missense_Mutation_p.M220L|RGS7_uc001hyt.2_Missense_Mutation_p.M52L	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	220					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GGGTTTCTCATTCTGGATGAC	0.403													0	0	0	0.014323	0	21	49										A	240990424	T	A	240990424	3	1	13	1	0	0	0	0	1	0	0	0	13310	1493	52	5	841	5	RGS7	1	240990424	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	3115359	240990424	8260197	30	3220										
PLD5	200150	broad.mit.edu	37	chr1	242428713	242428713	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcttgatttcaatattttgcGaagtcagctggagcaacttt	9	7	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:242428713G>A	uc001hzn.1	-	4	660	c.533C>T	c.(532-534)TCG>TTG	p.S178L	PLD5_uc001hzl.3_Missense_Mutation_p.S116L|PLD5_uc001hzm.3_5'UTR|PLD5_uc001hzo.1_Missense_Mutation_p.S86L			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	178						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AATATTTTGCGAAGTCAGCTG	0.358													0	0	0	0.010504	0	19	43										A	242428713	G	A	242428713	3	1	13	1	0	0	0	0	1	0	0	0	12049	1059	37	1	1105	1	PLD5	1	242428713	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1438289	242428713	6821908	31	3221										
ZNF124	7678	broad.mit.edu	37	chr1	247323048	247323048	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctctatagagattcttctggGaaggatccaacaaagcccac	8	11	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:247323048G>A	uc001ick.2	-	2	237	c.98C>T	c.(97-99)TCC>TTC	p.S33F	ZNF124_uc001ici.2_RNA|ZNF124_uc001icj.1_Missense_Mutation_p.S33F	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			ATTCTTCTGGGAAGGATCCAA	0.423													0	0	0	0.012213	0	31	72										A	247323048	G	A	247323048	3	1	13	1	0	0	0	0	1	0	0	0	17717	1174	41	1	783	1	ZNF124	1	247323048	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	4894335	247323048	1927573	32	3222										
ZNF496	84838	broad.mit.edu	37	chr1	247464253	247464253	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tccaggtcctcgctgtcgctGaacagctccccgcacaccga	9	18	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr1:247464253G>A	uc001ico.2	-	9	1797	c.1332C>T	c.(1330-1332)TTC>TTT	p.F444F	ZNF496_uc009xgv.2_Silent_p.F480F|ZNF496_uc001icp.2_Silent_p.F444F	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	444	C2H2-type 2.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CGCTGTCGCTGAACAGCTCCC	0.642													0	0	0	0.025465	0	40	50										A	247464253	G	A	247464253	2	1	13	1	0	0	0	0	0	0	0	1	17942	1281	45	1		1	ZNF496	1	247464253	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	141205	247464253	1786368	33	3223										
PXDN	7837	broad.mit.edu	37	chr2	1653407	1653407	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cccgacaggtttgcgatgagGttcaggtactgtggagacac	14	9	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:1653407G>T	uc002qxa.2	-	17	2209	c.2145C>A	c.(2143-2145)AAC>AAA	p.N715K		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	715					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TTGCGATGAGGTTCAGGTACT	0.592													1	0	7.83172e-31	0.019004	8.68445e-31	37	43										T	1653407	G	T	1653407	3	4	13	1	0	0	0	0	1	0	0	0	12847	1252	44	4	2322	4	PXDN	2	1653407	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		1653407	241545966	34	3224										
ASXL2	55252	broad.mit.edu	37	chr2	25978935	25978935	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggctgctgaagtgaagaattCattgttaagggctgagccat	13	6	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:25978935C>G	uc002rgs.2	-	9	1209	c.988G>C	c.(988-990)GAA>CAA	p.E330Q	ASXL2_uc002rgt.1_Missense_Mutation_p.E70Q	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGAAGAATTCATTGTTAAGG	0.448													0	0	0	0.01441	0	41	93										G	25978935	C	G	25978935	3	3	13	1	0	0	0	0	1	0	0	0	1067	835	29	1	3335	1	ASXL2	2	25978935	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	24325528	25978935	217220438	35	3225										
ASXL2	55252	broad.mit.edu	37	chr2	25994376	25994376	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tacctgctggaatggtgggtGatgggcagcctgactgcggg	18	8	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:25994376G>A	uc002rgs.2	-	5	658	c.437C>T	c.(436-438)TCA>TTA	p.S146L	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	146	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATGGTGGGTGATGGGCAGCC	0.443													0	0	0	0.010729	0	8	28										A	25994376	G	A	25994376	3	1	13	1	0	0	0	0	1	0	0	0	1067	1294	45	1	3902	1	ASXL2	2	25994376	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	15441	25994376	217204997	36	3226										
ASXL2	55252	broad.mit.edu	37	chr2	25994388	25994388	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tggtgggtgatgggcagcctGactgcggggaggacgacgat	20	7	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:25994388G>T	uc002rgs.2	-	5	646	c.425C>A	c.(424-426)TCA>TAA	p.S142*	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	142	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGGCAGCCTGACTGCGGGGA	0.453													1	0	6.40141e-05	0.010729	6.60626e-05	8	30										T	25994388	G	T	25994388	4	4	13	1	0	0	0	0	0	1	0	0	1067	1294	45	3	3914	3	ASXL2	2	25994388	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12	25994388	217204985	37	3227										
OTOF	9381	broad.mit.edu	37	chr2	26684967	26684967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccaccccctcacgaagatgtCactggacttctcccctgtga	7	17	3	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:26684967C>T	uc002rhk.2	-	42	5402	c.5275G>A	c.(5275-5277)GAC>AAC	p.D1759N	OTOF_uc010yla.1_Missense_Mutation_p.D489N|OTOF_uc002rhh.2_Missense_Mutation_p.D992N|OTOF_uc002rhi.2_Missense_Mutation_p.D1069N|OTOF_uc002rhj.2_Missense_Mutation_p.D992N	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1759	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACGAAGATGTCACTGGACTTC	0.617													0	0	0	0.01441	0	74	100										T	26684967	C	T	26684967	3	4	13	1	0	0	0	0	1	0	0	0	11303	826	29	1	923	1	OTOF	2	26684967	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	690579	26684967	216514406	38	3228										
DNAJC5G	285126	broad.mit.edu	37	chr2	27501157	27501157	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccacctgagcaggatagtggGagaaaatatcagcagaatgt	12	7	1	3	rs145408176		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:27501157G>A	uc002rjl.1	+	5	895	c.477G>A	c.(475-477)GGG>GGA	p.G159G	SLC30A3_uc010ylh.1_5'Flank|DNAJC5G_uc010yli.1_Missense_Mutation_p.G72E|DNAJC5G_uc002rjm.1_Silent_p.G159G	NM_173650	NP_775921	Q8N7S2	DNJ5G_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	159					protein folding	membrane	heat shock protein binding|unfolded protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGATAGTGGGAGAAAATATC	0.398													0	0	0	0.004672	0	3	24										A	27501157	G	A	27501157	2	1	13	1	0	0	0	0	0	0	0	1	4652	1161	41	1		1	DNAJC5G	2	27501157	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	816190	27501157	215698216	39	3229										
FEZ2	9637	broad.mit.edu	37	chr2	36808439	36808439	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcaggctcccttactctcttCataactgccggtactagacc	7	15	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:36808439C>T	uc002rph.2	-	4	675	c.628G>A	c.(628-630)GAA>AAA	p.E210K	FEZ2_uc002rpe.2_Missense_Mutation_p.E39K|FEZ2_uc002rpf.2_Missense_Mutation_p.E39K|FEZ2_uc002rpg.2_Missense_Mutation_p.E210K|FEZ2_uc002rpi.2_Missense_Mutation_p.E65K|FEZ2_uc002rpj.2_Missense_Mutation_p.E210K	NM_005102	NP_005093	Q9UHY8	FEZ2_HUMAN	zygin 2 isoform 1	210					axon guidance|signal transduction		protein binding			ovary(1)	1		all_hematologic(82;0.21)				TTACTCTCTTCATAACTGCCG	0.408													0	0	0	0.01441	0	90	158										T	36808439	C	T	36808439	3	4	13	1	0	0	0	0	1	0	0	0	5824	835	29	1	538	1	FEZ2	2	36808439	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	9307282	36808439	206390934	40	3230										
THADA	63892	broad.mit.edu	37	chr2	43458382	43458382	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggggacgccagccggactttGagaggagacagaagaggtgc	18	8	0	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:43458382G>C	uc002rsw.3	-	38	5919	c.5567C>G	c.(5566-5568)TCA>TGA	p.S1856*	THADA_uc010far.2_Nonsense_Mutation_p.S1051*|THADA_uc002rsx.3_Nonsense_Mutation_p.S1856*|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1856							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GCCGGACTTTGAGAGGAGACA	0.512													0	0	0	0.016723	0	11	16										C	43458382	G	C	43458382	4	2	13	1	0	0	0	0	0	1	0	0	15837	1294	45	1	298	1	THADA	2	43458382	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6649943	43458382	199740991	41	3231										
WBP1	23559	broad.mit.edu	37	chr2	74686773	74686773	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgcctccttgcccgcagcttCgagagctgtgcccaggagtg	13	14	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:74686773C>T	uc002slj.1	+	2	226	c.73C>T	c.(73-75)CGA>TGA	p.R25*	WBP1_uc002slh.1_RNA|INO80B_uc002sli.1_RNA|WBP1_uc002slk.1_Intron|WBP1_uc002sll.1_RNA	NM_012477	NP_036609	Q96G27	WBP1_HUMAN	WW domain binding protein 1	25							WW domain binding				0						CCCGCAGCTTCGAGAGCTGTG	0.592													0	0	0	0.01892	0	26	63										T	74686773	C	T	74686773	4	4	13	1	0	0	0	0	0	1	0	0	17254	876	31	1	79	1	WBP1	2	74686773	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	31228391	74686773	168512600	42	3232										
LRRTM1	347730	broad.mit.edu	37	chr2	80529770	80529770	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccccgccgtccgcgagcgtgGtggccgagctggcagggggc	19	15	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:80529770G>A	uc002sok.1	-	2	1445	c.1175C>T	c.(1174-1176)ACC>ATC	p.T392I	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	392	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CGCGAGCGTGGTGGCCGAGCT	0.721										HNSCC(69;0.2)			0	0	0	0.004482	0	8	31										A	80529770	G	A	80529770	3	1	13	1	0	0	0	0	1	0	0	0	9039	1261	44	2	397	2	LRRTM1	2	80529770	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	5842997	80529770	162669603	43	3233										
CTNNA2	1496	broad.mit.edu	37	chr2	80646667	80646667	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aggctgcaaagagcggaaatGaaaaggaagtgaaagaatat	13	3	0	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:80646667G>A	uc010ysh.1	+	8	1236	c.1231G>A	c.(1231-1233)GAA>AAA	p.E411K	CTNNA2_uc010yse.1_Missense_Mutation_p.E411K|CTNNA2_uc010ysf.1_Missense_Mutation_p.E411K|CTNNA2_uc010ysg.1_Missense_Mutation_p.E411K|CTNNA2_uc010ysi.1_Missense_Mutation_p.E43K	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	411					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAGCGGAAATGAAAAGGAAGT	0.458													0	0	0	0.014758	0	4	83										A	80646667	G	A	80646667	3	1	13	1	0	0	0	0	1	0	0	0	4013	1291	45	1	1053	1	CTNNA2	2	80646667	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	116897	80646667	162552706	44	3234										
VWA3B	200403	broad.mit.edu	37	chr2	98846623	98846623	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaatatgttgaagggaccatGgggcctttcagatcaaaagg	13	6	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:98846623G>C	uc002syo.2	+	16	2525	c.2261G>C	c.(2260-2262)TGG>TCG	p.W754S	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.W273S|VWA3B_uc002sym.2_Missense_Mutation_p.W754S|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.W411S|VWA3B_uc002syp.1_Missense_Mutation_p.W146S|VWA3B_uc002syq.1_Missense_Mutation_p.W30S|VWA3B_uc002syr.1_Missense_Mutation_p.W71S	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	754										ovary(3)|large_intestine(2)|skin(1)	6						AAGGGACCATGGGGCCTTTCA	0.413													0	0	0	0.01892	0	23	36										C	98846623	G	C	98846623	3	2	13	1	0	0	0	0	1	0	0	0	17238	1357	47	4	2319	4	VWA3B	2	98846623	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	18199956	98846623	144352750	45	3235										
AFF3	3899	broad.mit.edu	37	chr2	100210124	100210124	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgaagatgacgactctgtctCaatgaactccttggatttgg	10	8	2	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:100210124C>G	uc002tag.2	-	14	2235	c.1999G>C	c.(1999-2001)GAG>CAG	p.E667Q	AFF3_uc002taf.2_Missense_Mutation_p.E692Q|AFF3_uc010fiq.1_Missense_Mutation_p.E667Q|AFF3_uc010yvr.1_Missense_Mutation_p.E820Q|AFF3_uc002tah.1_Missense_Mutation_p.E692Q	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	667					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GACTCTGTCTCAATGAACTCC	0.622													0	0	0	0.01441	0	47	94										G	100210124	C	G	100210124	3	3	13	1	0	0	0	0	1	0	0	0	358	835	29	1	1725	1	AFF3	2	100210124	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1363501	100210124	142989249	46	3236										
NPAS2	4862	broad.mit.edu	37	chr2	101580599	101580599	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctaggaaaggaggtttgcttCattgccaccgttcgtctggc	12	10	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:101580599C>T	uc002tap.1	+	8	964	c.678C>T	c.(676-678)TTC>TTT	p.F226F	NPAS2_uc010yvt.1_Silent_p.F291F	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	226					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						AGGTTTGCTTCATTGCCACCG	0.493													0	0	0	0.015359	0	33	49										T	101580599	C	T	101580599	2	4	13	1	0	0	0	0	0	0	0	1	10563	825	29	1		1	NPAS2	2	101580599	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1370475	101580599	141618774	47	3237										
POLR2D	5433	broad.mit.edu	37	chr2	128605685	128605685	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cagtgatgtttggagattaaTactgaaagctgcgctttgtc	11	6	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:128605685T>C	uc002tpj.2	-	4	480	c.425A>G	c.(424-426)TAT>TGT	p.Y142C	uc010fmc.2_5'Flank|POLR2D_uc002tpk.2_Missense_Mutation_p.Y110C	NM_004805	NP_004796	O15514	RPB4_HUMAN	DNA directed RNA polymerase II polypeptide D	142					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		TGGAGATTAATACTGAAAGCT	0.458													0	0	0	0.024245	0	14	31										C	128605685	T	C	128605685	3	2	13	1	0	0	0	0	1	0	0	0	12217	1406	49	5	7	5	POLR2D	2	128605685	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	27025086	128605685	114593688	48	3238										
LCT	3938	broad.mit.edu	37	chr2	136570082	136570082	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccaagaggatgaggtctgggGccacacatggttcacgtgtt	14	9	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:136570082G>A	uc002tuu.1	-	7	2163	c.2152C>T	c.(2152-2154)CCC>TCC	p.P718S		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	718	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAGGTCTGGGGCCACACATGG	0.517													0	0	0	0.014323	0	22	41										A	136570082	G	A	136570082	3	1	13	1	0	0	0	0	1	0	0	0	8693	1203	42	2	3675	2	LCT	2	136570082	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	7964397	136570082	106629291	49	3239										
SCN1A	6323	broad.mit.edu	37	chr2	166848324	166848324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttttcaaattccatgaactGagttgcatcgggatcaaact	7	8	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:166848324G>C	uc010zcz.1	-	26	5446	c.5428C>G	c.(5428-5430)CAG>GAG	p.Q1810E		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1821	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCCATGAACTGAGTTGCATCG	0.443													0	0	0	0.010818	0	34	97										C	166848324	G	C	166848324	3	2	13	1	0	0	0	0	1	0	0	0	13914	1299	45	1	572	1	SCN1A	2	166848324	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	30278242	166848324	76351049	50	3240										
TTN	7273	broad.mit.edu	37	chr2	179400360	179400360	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	catagaaaccagcatcttttCtctctaccccattggggaaa	6	12	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:179400360C>G	uc010zfg.1	-	307	93502	c.93278G>C	c.(93277-93279)AGA>ACA	p.R31093T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R24788T|TTN_uc010zfi.1_Missense_Mutation_p.R24721T|TTN_uc010zfj.1_Missense_Mutation_p.R24596T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32020							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCATCTTTTCTCTCTACCCC	0.433													0	0	0	0.01441	0	48	95										G	179400360	C	G	179400360	3	3	13	1	0	0	0	0	1	0	0	0	16732	913	32	1	7017	1	TTN	2	179400360	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	12552036	179400360	63799013	51	3241										
TTN	7273	broad.mit.edu	37	chr2	179584463	179584463	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	catctttgaaccacttggctGagagttctggtgttccagtc	10	10	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:179584463G>C	uc010zfg.1	-	79	20248	c.20024C>G	c.(20023-20025)TCA>TGA	p.S6675*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.S3336*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7602							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACTTGGCTGAGAGTTCTGG	0.433													0	0	0	0.027356	0	29	45										C	179584463	G	C	179584463	4	2	13	1	0	0	0	0	0	1	0	0	16732	1294	45	1	80897	1	TTN	2	179584463	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	184103	179584463	63614910	52	3242										
RFTN2	130132	broad.mit.edu	37	chr2	198498722	198498722	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cttttagcagcgacattaatCtgatatttaaaaagagatgg	8	5	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:198498722C>G	uc002uuo.3	-	4	841	c.439_splice	c.e4-1	p.I147_splice		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2							plasma membrane					0						CGACATTAATCTGATATTTAA	0.318													0	0	0	0.024245	0	16	39										G	198498722	C	G	198498722	5	3	13	1	0	0	0	0	0	0	1	0	13259	927	32	1	1091	1	RFTN2	2	198498722	Splice_Site	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	18914259	198498722	44700651	53	3243										
ZDBF2	57683	broad.mit.edu	37	chr2	207175392	207175392	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtttatatgcaaatataaacGgaatatctttgattattatg	6	3	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:207175392G>A	uc002vbp.2	+	5	6390	c.6140G>A	c.(6139-6141)CGG>CAG	p.R2047Q		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2047							nucleic acid binding|zinc ion binding			ovary(3)	3						AAATATAAACGGAATATCTTT	0.358													0	0	0	0.004482	0	9	19										A	207175392	G	A	207175392	3	1	13	1	0	0	0	0	1	0	0	0	17596	1116	39	2	6150	2	ZDBF2	2	207175392	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	8676670	207175392	36023981	54	3244										
PLCD4	84812	broad.mit.edu	37	chr2	219483480	219483480	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atatggatgcgagggctccaGctgttggtggatcttgtcac	14	8	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:219483480G>T	uc002vij.1	+	4	555	c.360G>T	c.(358-360)CAG>CAT	p.Q120H	PLCD4_uc010zkj.1_Missense_Mutation_p.Q67H|PLCD4_uc002vik.1_5'Flank|PLCD4_uc010zkk.1_5'Flank	NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	120	PH.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAGGGCTCCAGCTGTTGGTGG	0.602													1	0	0.000602214	0.014758	0.000618188	4	15										T	219483480	G	T	219483480	3	4	13	1	0	0	0	0	1	0	0	0	12033	962	34	4	370	4	PLCD4	2	219483480	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12308088	219483480	23715893	55	3245										
PTPRN	5798	broad.mit.edu	37	chr2	220161229	220161229	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtaggctggcatccgagggtCatgctcaatctggaggcagg	16	9	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:220161229C>A	uc002vkz.2	-	17	2409	c.2320G>T	c.(2320-2322)GAC>TAC	p.D774Y	PTPRN_uc010zlc.1_Missense_Mutation_p.D684Y|PTPRN_uc002vla.2_Missense_Mutation_p.D745Y|uc010zld.1_5'Flank|MIR153-1_hsa-mir-153-1|MI0000463_5'Flank	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	774	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		ATCCGAGGGTCATGCTCAATC	0.592													1	0	3.41278e-10	0.00499	3.66874e-10	17	39										A	220161229	C	A	220161229	3	1	13	1	0	0	0	0	1	0	0	0	12807	826	29	3	647	3	PTPRN	2	220161229	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	677749	220161229	23038144	56	3246										
DOCK10	55619	broad.mit.edu	37	chr2	225670030	225670030	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agccaatcaaagacaagggtCttgggatctgggaattcaag	12	7	4	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:225670030C>G	uc010fwz.1	-	36	4183	c.3944G>C	c.(3943-3945)AGA>ACA	p.R1315T	DOCK10_uc002vob.2_Missense_Mutation_p.R1309T|DOCK10_uc002voa.2_5'UTR|DOCK10_uc002voc.2_Missense_Mutation_p.R169T	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1315							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AGACAAGGGTCTTGGGATCTG	0.418													0	0	0	0.00874	0	40	52										G	225670030	C	G	225670030	3	3	13	1	0	0	0	0	1	0	0	0	4685	913	32	1	2700	1	DOCK10	2	225670030	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5508801	225670030	17529343	57	3247										
SPHKAP	80309	broad.mit.edu	37	chr2	228881535	228881535	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gctaatctatttgcacacttCtctgcttgcgagggagagcc	10	11	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:228881535C>G	uc002vpq.2	-	7	4082	c.4035G>C	c.(4033-4035)GAG>GAC	p.E1345D	SPHKAP_uc002vpp.2_Missense_Mutation_p.E1345D|SPHKAP_uc010zlx.1_Missense_Mutation_p.E1345D	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1345						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTGCACACTTCTCTGCTTGCG	0.512													0	0	0	0.007413	0	20	50										G	228881535	C	G	228881535	3	3	13	1	0	0	0	0	1	0	0	0	15047	912	32	1	1091	1	SPHKAP	2	228881535	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3211505	228881535	14317838	58	3248										
GPR55	9290	broad.mit.edu	37	chr2	231775157	231775157	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccttggcgctccaggtatcaTcagacatgttgtggaagcac	11	11	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:231775157T>A	uc002vrg.2	-	2	714	c.521A>T	c.(520-522)GAT>GTT	p.D174V	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.D174V	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	174	Extracellular (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		CCAGGTATCATCAGACATGTT	0.532													0	0	0	0.01441	0	49	58										A	231775157	T	A	231775157	3	1	13	1	0	0	0	0	1	0	0	0	6699	1435	50	5	442	5	GPR55	2	231775157	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	2893622	231775157	11424216	59	3249										
HJURP	55355	broad.mit.edu	37	chr2	234749700	234749700	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttctttaatttcatcgtaacGattccttccgtggcctggca	7	11	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:234749700G>A	uc002vvg.2	-	8	1792	c.1726C>T	c.(1726-1728)CGT>TGT	p.R576C	HJURP_uc010znd.1_Missense_Mutation_p.R515C|HJURP_uc010zne.1_Missense_Mutation_p.R484C	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	576					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TCATCGTAACGATTCCTTCCG	0.413													0	0	0	0.010818	0	32	59										A	234749700	G	A	234749700	3	1	13	1	0	0	0	0	1	0	0	0	7189	1058	37	1	528	1	HJURP	2	234749700	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2974543	234749700	8449673	60	3250										
COL6A3	1293	broad.mit.edu	37	chr2	238277457	238277457	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acacatcgtcctgggattttCcacccaggaccaggaccagg	10	14	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:238277457C>T	uc002vwl.2	-	10	4934	c.4649G>A	c.(4648-4650)GGA>GAA	p.G1550E	COL6A3_uc002vwo.2_Missense_Mutation_p.G1344E|COL6A3_uc010znj.1_Missense_Mutation_p.G943E	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1550	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGGGATTTTCCACCCAGGAC	0.562													0	0	0	0.007291	0	30	86										T	238277457	C	T	238277457	3	4	13	1	0	0	0	0	1	0	0	0	3701	855	30	1	5024	1	COL6A3	2	238277457	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3527757	238277457	4921916	61	3251										
HDAC4	9759	broad.mit.edu	37	chr2	240036766	240036766	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cacctgtctgaagagcagctCctgctcactgggctggcgct	12	14	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:240036766C>G	uc002vyk.3	-	13	2551	c.1759G>C	c.(1759-1761)GAG>CAG	p.E587Q	HDAC4_uc010fyz.1_Missense_Mutation_p.E582Q|HDAC4_uc010zoa.1_Missense_Mutation_p.E587Q|HDAC4_uc010fza.2_Missense_Mutation_p.E592Q|HDAC4_uc010fyy.2_Missense_Mutation_p.E544Q|HDAC4_uc010znz.1_Missense_Mutation_p.E470Q	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	587					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AAGAGCAGCTCCTGCTCACTG	0.677													0	0	0	0.01892	0	24	30										G	240036766	C	G	240036766	3	3	13	1	0	0	0	0	1	0	0	0	7009	864	30	1	1555	1	HDAC4	2	240036766	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1759309	240036766	3162607	62	3252										
PASK	23178	broad.mit.edu	37	chr2	242066101	242066101	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcactgaaaaagagttccttGaggttccaggaaaacgaatt	9	7	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:242066101G>C	uc002wao.1	-	10	2321	c.2229C>G	c.(2227-2229)CTC>CTG	p.L743L	PASK_uc010zol.1_Silent_p.L557L|PASK_uc010zom.1_Silent_p.L708L|PASK_uc010fzl.1_Silent_p.L743L|PASK_uc010zon.1_Silent_p.L524L|PASK_uc002wap.2_Silent_p.L286L|PASK_uc002waq.2_Silent_p.L743L	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	743					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		AGAGTTCCTTGAGGTTCCAGG	0.547													0	0	0	0.027356	0	27	41										C	242066101	G	C	242066101	2	2	13	1	0	0	0	0	0	0	0	1	11472	1277	45	1		1	PASK	2	242066101	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2029335	242066101	1133272	63	3253										
PASK	23178	broad.mit.edu	37	chr2	242066280	242066280	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gacagcctggcactctgtcgGaacgagttcggcgtggggga	17	10	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:242066280G>A	uc002wao.1	-	10	2142	c.2050C>T	c.(2050-2052)CCG>TCG	p.P684S	PASK_uc010zol.1_Missense_Mutation_p.P498S|PASK_uc010zom.1_Missense_Mutation_p.P649S|PASK_uc010fzl.1_Missense_Mutation_p.P684S|PASK_uc010zon.1_Missense_Mutation_p.P465S|PASK_uc002wap.2_Missense_Mutation_p.P227S|PASK_uc002waq.2_Missense_Mutation_p.P684S	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	684					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CACTCTGTCGGAACGAGTTCG	0.622													0	0	0	0.01441	0	64	82										A	242066280	G	A	242066280	3	1	13	1	0	0	0	0	1	0	0	0	11472	1174	41	1	1957	1	PASK	2	242066280	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	179	242066280	1133093	64	3254										
HDLBP	3069	broad.mit.edu	37	chr2	242192385	242192385	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cactcactgttggcaccgctCttcccaatgaggtgcctgtg	10	14	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr2:242192385C>G	uc002waz.2	-	11	1587	c.1359G>C	c.(1357-1359)AAG>AAC	p.K453N	HDLBP_uc002wba.2_Missense_Mutation_p.K453N|HDLBP_uc002wbb.2_Missense_Mutation_p.K405N	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	453	KH 5.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TGGCACCGCTCTTCCCAATGA	0.582													0	0	0	0.020292	0	13	74										G	242192385	C	G	242192385	3	3	13	1	0	0	0	0	1	0	0	0	7025	912	32	1	2519	1	HDLBP	2	242192385	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	126105	242192385	1006988	65	3255										
ZFYVE20	64145	broad.mit.edu	37	chr3	15124021	15124021	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctgacactgctcatgctgctGatgctgcctcggcgggagcc	13	14	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:15124021G>T	uc003bzm.1	-	9	1307	c.693C>A	c.(691-693)ATC>ATA	p.I231I	ZFYVE20_uc010hek.1_Silent_p.I231I|ZFYVE20_uc011avn.1_Intron	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	231	FYVE-type.|Ser-rich.|Necessary for the correct targeting to endosomes.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						TCATGCTGCTGATGCTGCCTC	0.602													1	0	2.21704e-12	0.016522	2.41688e-12	20	20										T	15124021	G	T	15124021	2	4	13	1	0	0	0	0	0	0	0	1	17663	1280	45	3		3	ZFYVE20	3	15124021	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		15124021	182898409	66	3256										
OSBPL10	114884	broad.mit.edu	37	chr3	31710301	31710301	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtgttggttgggttgtgcttCacttctgcggtaaccctgaa	13	8	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:31710301C>T	uc003cev.2	-	11	2310	c.1929G>A	c.(1927-1929)GTG>GTA	p.V643V	OSBPL10_uc003ceu.1_Silent_p.V400V|OSBPL10_uc011axf.1_Silent_p.V579V	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	643					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		GGTTGTGCTTCACTTCTGCGG	0.393													0	0	0	0.013114	0	44	36										T	31710301	C	T	31710301	2	4	13	1	0	0	0	0	0	0	0	1	11275	813	29	1		1	OSBPL10	3	31710301	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	16586280	31710301	166312129	67	3257										
ZNF167	55888	broad.mit.edu	37	chr3	44612209	44612209	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gagagcattctgttccaataGaaatctcattgaccatcaga	7	9	3	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:44612209G>C	uc010hin.2	+	6	1995	c.1607G>C	c.(1606-1608)AGA>ACA	p.R536T	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.R536T|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	536	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TGTTCCAATAGAAATCTCATT	0.438													0	0	0	0.025465	0	39	27										C	44612209	G	C	44612209	3	2	13	1	0	0	0	0	1	0	0	0	17738	942	33	1	1625	1	ZNF167	3	44612209	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12901908	44612209	153410221	68	3258										
PTH1R	5745	broad.mit.edu	37	chr3	46939420	46939420	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aggtgaggtggtggctgtgcCctgtccggactacatttatg	15	8	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:46939420C>T	uc003cqm.2	+	6	592	c.389C>T	c.(388-390)CCC>CTC	p.P130L	PTH1R_uc003cqn.2_Missense_Mutation_p.P130L	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	130	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GTGGCTGTGCCCTGTCCGGAC	0.607									Ollier_disease_/_Maffuci_syndrome				0	0	0	0.007413	0	20	15										T	46939420	C	T	46939420	3	4	13	1	0	0	0	0	1	0	0	0	12758	623	22	2	403	2	PTH1R	3	46939420	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2327211	46939420	151083010	69	3259										
P4HTM	54681	broad.mit.edu	37	chr3	49043565	49043565	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gacaagggaaacctgcgtgtCaagccccaacagggcacagc	12	13	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:49043565C>G	uc003cvg.2	+	8	1582	c.1233C>G	c.(1231-1233)GTC>GTG	p.V411V	P4HTM_uc003cvh.2_Silent_p.V472V|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	411	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	ACCTGCGTGTCAAGCCCCAAC	0.612													0	0	0	0.009535	0	32	36										G	49043565	C	G	49043565	2	3	13	1	0	0	0	0	0	0	0	1	11360	813	29	1		1	P4HTM	3	49043565	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2104145	49043565	148978865	70	3260										
LAMB2	3913	broad.mit.edu	37	chr3	49161498	49161498	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acctgtgaagcggtgacactGaggtgtatctattccacgag	12	9	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:49161498G>A	uc003cwe.2	-	24	3759	c.3460C>T	c.(3460-3462)CAG>TAG	p.Q1154*		NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1154	Laminin EGF-like 13.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGGTGACACTGAGGTGTATCT	0.562													0	0	0	0.016723	0	13	11										A	49161498	G	A	49161498	4	1	13	1	0	0	0	0	0	1	0	0	8611	1299	45	1	1972	1	LAMB2	3	49161498	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	117933	49161498	148860932	71	3261										
NISCH	11188	broad.mit.edu	37	chr3	52526262	52526262	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcatgggctaccagacctacCcgcaggccctcaccctcgtc	8	19	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:52526262C>T	uc011beg.1	+	22	4351	c.4279C>T	c.(4279-4281)CCG>TCG	p.P1427S	NISCH_uc003ded.3_Missense_Mutation_p.P1427S|NISCH_uc003dee.3_Missense_Mutation_p.P916S|NISCH_uc003deg.1_Intron|NISCH_uc003deh.3_Missense_Mutation_p.P176S	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1427					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCAGACCTACCCGCAGGCCCT	0.652													0	0	0	0.01441	0	67	65										T	52526262	C	T	52526262	3	4	13	1	0	0	0	0	1	0	0	0	10432	623	22	2	4361	2	NISCH	3	52526262	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3364764	52526262	145496168	72	3262										
SLMAP	7871	broad.mit.edu	37	chr3	57827095	57827095	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tatggaagcccggctccgctCagagtgagtataatttagta	11	8	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:57827095C>G	uc003dje.1	+	3	621	c.416C>G	c.(415-417)TCA>TGA	p.S139*	SLMAP_uc003djc.1_Nonsense_Mutation_p.S139*|SLMAP_uc003djd.1_Nonsense_Mutation_p.S139*|SLMAP_uc003djf.1_Nonsense_Mutation_p.S139*	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	139	Necessary for targeting to centrosomes (By similarity).|Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		CGGCTCCGCTCAGAGTGAGTA	0.358													0	0	0	0.00308	0	6	35										G	57827095	C	G	57827095	4	3	13	1	0	0	0	0	0	1	0	0	14749	838	29	1	426	1	SLMAP	3	57827095	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5300833	57827095	140195335	73	3263										
ZDHHC23	254887	broad.mit.edu	37	chr3	113673211	113673211	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cagcccgggcatggcactgcCggatatgtggcatctgtgtg	15	11	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:113673211C>A	uc003eau.2	+	3	1125	c.826C>A	c.(826-828)CGG>AGG	p.R276R	ZDHHC23_uc003eav.2_Silent_p.R270R	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	276	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						ATGGCACTGCCGGATATGTGG	0.517													1	0	1.12685e-05	0.004482	1.17862e-05	9	22										A	113673211	C	A	113673211	2	1	13	1	0	0	0	0	0	0	0	1	17611	643	23	4		4	ZDHHC23	3	113673211	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	55846116	113673211	84349219	74	3264										
HCLS1	3059	broad.mit.edu	37	chr3	121354589	121354589	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cactaagcctcaccggcttcTatgggcgtcgtcttcttata	8	13	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:121354589T>C	uc003eeh.3	-	9	809	c.684A>G	c.(682-684)ATA>ATG	p.I228M	HCLS1_uc011bjj.1_Missense_Mutation_p.I191M|HCLS1_uc011bjk.1_RNA	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	228					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		CACCGGCTTCTATGGGCGTCG	0.522													0	0	0	0.01441	0	46	49										C	121354589	T	C	121354589	3	2	13	1	0	0	0	0	1	0	0	0	6995	1512	53	5	800	5	HCLS1	3	121354589	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	7681378	121354589	76667841	75	3265										
PARP9	83666	broad.mit.edu	37	chr3	122247537	122247537	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agagattttcttggccttctCtgccaggtttttgaggttct	10	8	3	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:122247537C>T	uc010hri.2	-	11	2384	c.2239G>A	c.(2239-2241)GAG>AAG	p.E747K	PARP9_uc003eff.3_Missense_Mutation_p.E712K|PARP9_uc011bjs.1_Missense_Mutation_p.E712K|PARP9_uc003efg.2_Missense_Mutation_p.E292K|PARP9_uc003efi.2_Missense_Mutation_p.E712K|PARP9_uc003efh.2_Missense_Mutation_p.E747K	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	747	PARP catalytic.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TTGGCCTTCTCTGCCAGGTTT	0.373													0	0	0	0.010771	0	42	68										T	122247537	C	T	122247537	3	4	13	1	0	0	0	0	1	0	0	0	11466	922	32	1	329	1	PARP9	3	122247537	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	892948	122247537	75774893	76	3266										
HEG1	57493	broad.mit.edu	37	chr3	124738228	124738228	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cagactgtacagtagagtctGagaactgggtcaacactgaa	11	8	2	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:124738228G>C	uc003ehs.3	-	5	1534	c.1466C>G	c.(1465-1467)TCA>TGA	p.S489*	HEG1_uc011bke.1_Nonsense_Mutation_p.S489*	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	489	Extracellular (Potential).|Ser-rich.					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						AGTAGAGTCTGAGAACTGGGT	0.463													0	0	0	0.021022	0	39	164										C	124738228	G	C	124738228	4	2	13	1	0	0	0	0	0	1	0	0	7044	1294	45	1	2731	1	HEG1	3	124738228	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2490691	124738228	73284202	77	3267										
CCDC48	79825	broad.mit.edu	37	chr3	128753034	128753034	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaccagacggcggagaagctCatgacttactttggtcactt	11	10	2	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:128753034C>T	uc011bkt.1	+	5	1311	c.1311C>T	c.(1309-1311)CTC>CTT	p.L437L		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	coiled-coil domain containing 48	437											0						CGGAGAAGCTCATGACTTACT	0.622													0	0	0	0.01892	0	23	56										T	128753034	C	T	128753034	2	4	13	1	0	0	0	0	0	0	0	1	2819	813	29	1		1	CCDC48	3	128753034	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	4014806	128753034	69269396	78	3268										
COPG	22820	broad.mit.edu	37	chr3	128982840	128982840	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgttcaccatgctgcgggaaGaggtaagagtcaggggcatt	15	7	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:128982840G>C	uc003els.2	+	13	1322	c.1222G>C	c.(1222-1224)GAG>CAG	p.E408Q	COPG_uc010htb.2_Missense_Mutation_p.E314Q	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	408					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						GCTGCGGGAAGAGGTAAGAGT	0.547													0	0	0	0.008291	0	10	18										C	128982840	G	C	128982840	3	2	13	1	0	0	0	0	1	0	0	0	3731	943	33	1	1272	1	COPG	3	128982840	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	229806	128982840	69039590	79	3269										
C3orf37	56941	broad.mit.edu	37	chr3	129023617	129023617	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggactcctagagcaatggctGaagcgggagaaggaggagga	18	6	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:129023617G>A	uc003elt.2	+	7	1102	c.1014G>A	c.(1012-1014)CTG>CTA	p.L338L	C3orf37_uc003elu.2_Silent_p.L296L|C3orf37_uc003elv.2_Silent_p.L338L|C3orf37_uc003elw.2_Silent_p.L338L	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	338										ovary(1)	1						AGCAATGGCTGAAGCGGGAGA	0.562													0	0	0	0.006122	0	19	18										A	129023617	G	A	129023617	2	1	13	1	0	0	0	0	0	0	0	1	2227	1277	45	1		1	C3orf37	3	129023617	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	40777	129023617	68998813	80	3270										
TOPBP1	11073	broad.mit.edu	37	chr3	133341981	133341982	+	Frame_Shift_Del	DEL	TT	TT	-													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccatttgatggtgctgactcTttattattggtggccatatt							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:133341981_133341982delTT	uc003eps.2	-	19	3263_3264	c.3131_3132delAA	c.(3130-3132)AAAfs	p.K1044fs	TOPBP1_uc003ept.1_Frame_Shift_Del_p.K48fs	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1044					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						GTGCTGACTCTTTATTATTGGT	0.287								Other_conserved_DNA_damage_response_genes										13	23	---	---								-	133341982	TT	-	133341981	7	5	13	1	0	1	0	1	0	0	0	0	16366	1606	56	0	1476	0	TOPBP1	3	133341981	Frame_Shift_Del	DEL	TT	TCGA-BT-A20T-01A-11D-A14W-08	4318364	133341981	64680449	81	3271										
PPP2R3A	5523	broad.mit.edu	37	chr3	135721655	135721655	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agacagagaatggacctagtCatgagttattaaaggtaaat	10	4	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:135721655C>T	uc003eqv.1	+	2	1880	c.1315C>T	c.(1315-1317)CAT>TAT	p.H439Y	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	439					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						TGGACCTAGTCATGAGTTATT	0.348													0	0	0	0.021022	0	36	63										T	135721655	C	T	135721655	3	4	13	1	0	0	0	0	1	0	0	0	12388	826	29	1	1317	1	PPP2R3A	3	135721655	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2379674	135721655	62300775	82	3272										
KIAA0226	9711	broad.mit.edu	37	chr3	197408132	197408132	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acgtagtacttgctgaagtcCcacttgcgcagaacccggct	10	13	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr3:197408132C>T	uc003fyc.2	-	16	2481	c.2298G>A	c.(2296-2298)TGG>TGA	p.W766*	KIAA0226_uc003fyd.3_Nonsense_Mutation_p.W721*|KIAA0226_uc003fye.1_Nonsense_Mutation_p.W498*	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	766					autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TGCTGAAGTCCCACTTGCGCA	0.537													0	0	0	0.021553	0	5	134										T	197408132	C	T	197408132	4	4	13	1	0	0	0	0	0	1	0	0	8162	624	22	2	640	2	KIAA0226	3	197408132	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	61686477	197408132	614298	83	3273										
FGFR3	2261	broad.mit.edu	37	chr4	1806119	1806119	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgcaggcatcctcagctacGgggtgggcttcttcctgttc	12	12	2	0	rs28931614		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:1806119G>A	uc003gdr.3	+	9	1394	c.1138G>A	c.(1138-1140)GGG>AGG	p.G380R	FGFR3_uc003gdu.2_Missense_Mutation_p.G382R|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.G380R	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	380	Helical; (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.G380R(15)|p.G380E(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCTCAGCTACGGGGTGGGCTT	0.672		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	156	222										A	1806119	G	A	1806119	3	1	13	1	0	0	0	0	1	0	0	0	5867	1116	39	2	1323	2	FGFR3	4	1806119	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		1806119	189348157	84	3274										
WHSC1	7468	broad.mit.edu	37	chr4	1957529	1957529	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aatgactgcagggctgggaaGaagctgcacttccaggatat	13	8	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:1957529G>A	uc003gdz.3	+	14	2804	c.2628G>A	c.(2626-2628)AAG>AAA	p.K876K	WHSC1_uc003geb.3_Silent_p.K876K|WHSC1_uc003gec.3_Silent_p.K876K|WHSC1_uc003ged.3_Silent_p.K876K|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.K95K|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Silent_p.K224K	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	876					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGGCTGGGAAGAAGCTGCACT	0.507			T	IGH@	MM								0	0	0	0.028581	0	17	34										A	1957529	G	A	1957529	2	1	13	1	0	0	0	0	0	0	0	1	17359	933	33	1		1	WHSC1	4	1957529	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	151410	1957529	189196747	85	3275										
ZBTB49	166793	broad.mit.edu	37	chr4	4317400	4317400	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acgtccagcgtcacattattAttcactcaggagaaaaacca	6	11	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:4317400A>T	uc003ghu.2	+	6	1589	c.1414A>T	c.(1414-1416)ATT>TTT	p.I472F	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	472	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TCACATTATTATTCACTCAGG	0.393													0	0	0	0.016522	0	21	29										T	4317400	A	T	4317400	3	4	13	1	0	0	0	0	1	0	0	0	17547	449	16	5	1432	5	ZBTB49	4	4317400	Missense_Mutation	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	2359871	4317400	186836876	86	3276										
BST1	683	broad.mit.edu	37	chr4	15716979	15716979	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccaacaggagcctatcccatCaaagggtaagaacaccagca	8	13	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:15716979C>G	uc003goh.3	+	5	801	c.606C>G	c.(604-606)ATC>ATG	p.I202M	BST1_uc003goi.2_Missense_Mutation_p.I13M	NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	202					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1						CCTATCCCATCAAAGGGTAAG	0.388													0	0	0	0.010729	0	10	22										G	15716979	C	G	15716979	3	3	13	1	0	0	0	0	1	0	0	0	1533	816	29	1	624	1	BST1	4	15716979	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	11399579	15716979	175437297	87	3277										
STIM2	57620	broad.mit.edu	37	chr4	26959236	26959236	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgttttctcttctatagttCatcagagaagatatgaaata	6	5	4	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:26959236C>T	uc003gsh.3	+	3	762	c.546C>T	c.(544-546)TTC>TTT	p.F182F	STIM2_uc003gsg.3_Silent_p.F182F|STIM2_uc010iex.2_Silent_p.F182F	NM_020860	NP_065911	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	95	EF-hand.|Extracellular (Potential).				activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)				TTCTATAGTTCATCAGAGAAG	0.308													0	0	0	0.00499	0	18	70										T	26959236	C	T	26959236	2	4	13	1	0	0	0	0	0	0	0	1	15283	825	29	1		1	STIM2	4	26959236	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	11242257	26959236	164195040	88	3278										
GABRB1	2560	broad.mit.edu	37	chr4	47322172	47322172	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccacagctgcatgtatgatgGatcttcgaagatatccattg	9	9	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:47322172G>C	uc003gxh.2	+	5	864	c.490G>C	c.(490-492)GAT>CAT	p.D164H	GABRB1_uc011bze.1_Missense_Mutation_p.D94H	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	164	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATGTATGATGGATCTTCGAAG	0.423													0	0	0	0.028581	0	15	43										C	47322172	G	C	47322172	3	2	13	1	0	0	0	0	1	0	0	0	6166	1174	41	1	508	1	GABRB1	4	47322172	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	20362936	47322172	143832104	89	3279										
C4orf14	84273	broad.mit.edu	37	chr4	57829697	57829697	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gttttataggccacacttttCttgatgcgctgtcctttgat	8	9	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:57829697C>G	uc003hck.2	-	7	2091	c.2016G>C	c.(2014-2016)AAG>AAC	p.K672N		NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	672							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					CCACACTTTTCTTGATGCGCT	0.458													0	0	0	0.01441	0	68	121										G	57829697	C	G	57829697	3	3	13	1	0	0	0	0	1	0	0	0	2251	912	32	1	84	1	C4orf14	4	57829697	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	10507525	57829697	133324579	90	3280										
EPHA5	2044	broad.mit.edu	37	chr4	66230766	66230766	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acaccttctaaatggatgatGttaggatgatcaaactgtcc	8	8	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:66230766G>A	uc003hcy.2	-	12	2398	c.2205C>T	c.(2203-2205)AAC>AAT	p.N735N	EPHA5_uc003hcx.2_Silent_p.N667N|EPHA5_uc003hcz.2_Silent_p.N713N|EPHA5_uc011cah.1_Silent_p.N736N|EPHA5_uc011cai.1_Silent_p.N714N|EPHA5_uc003hda.2_Silent_p.N736N	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	735	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AATGGATGATGTTAGGATGAT	0.363										TSP Lung(17;0.13)			0	0	0	0.01441	0	49	69										A	66230766	G	A	66230766	2	1	13	1	0	0	0	0	0	0	0	1	5170	1368	48	2		2	EPHA5	4	66230766	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	8401069	66230766	124923510	91	3281										
TMPRSS11F	389208	broad.mit.edu	37	chr4	68930646	68930646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	accaaaagtagcaatccattGagttgggtctttatttctgc	8	8	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:68930646G>C	uc003hdt.1	-	8	821	c.772C>G	c.(772-774)CAA>GAA	p.Q258E	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron|SYT14L_uc010ihn.2_5'Flank	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	258	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GCAATCCATTGAGTTGGGTCT	0.338													0	0	0	0.028581	0	17	28										C	68930646	G	C	68930646	3	2	13	1	0	0	0	0	1	0	0	0	16240	1299	45	1	556	1	TMPRSS11F	4	68930646	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2699880	68930646	122223630	92	3282										
C4orf17	84103	broad.mit.edu	37	chr4	100463168	100463168	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctcctcccaggcctaacactCaggagagtggatcagcaaaa	9	13	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:100463168C>G	uc003huw.2	+	9	1305	c.982C>G	c.(982-984)CAG>GAG	p.Q328E	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	328											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		GCCTAACACTCAGGAGAGTGG	0.433													0	0	0	0.020292	0	14	50										G	100463168	C	G	100463168	3	3	13	1	0	0	0	0	1	0	0	0	2252	827	29	1	1012	1	C4orf17	4	100463168	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	31532522	100463168	90691108	93	3283										
SLC39A8	64116	broad.mit.edu	37	chr4	103228665	103228665	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cccacaaaaaaggtcaaaatCtttgggaaataagatttctt	6	7	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:103228665C>A	uc003hwb.1	-	3	1009	c.480G>T	c.(478-480)AAG>AAT	p.K160N	SLC39A8_uc011ceo.1_Missense_Mutation_p.K160N|SLC39A8_uc003hwa.1_Missense_Mutation_p.K93N|SLC39A8_uc003hwc.2_Missense_Mutation_p.K160N	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	160	Extracellular (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		AGGTCAAAATCTTTGGGAAAT	0.388													1	0	2.05175e-36	0.01441	2.28169e-36	72	125										A	103228665	C	A	103228665	3	1	13	1	0	0	0	0	1	0	0	0	14624	912	32	3	1003	3	SLC39A8	4	103228665	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2765497	103228665	87925611	94	3284										
KIAA1109	84162	broad.mit.edu	37	chr4	123192861	123192861	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaatattggaaaagtcttcaGaaacatttggaccagcaggt	10	6	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:123192861G>A	uc003ieh.2	+	45	8227	c.8182G>A	c.(8182-8184)GAA>AAA	p.E2728K	KIAA1109_uc003iel.1_Missense_Mutation_p.E663K|KIAA1109_uc003iek.2_Missense_Mutation_p.E1347K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2728					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AAAGTCTTCAGAAACATTTGG	0.338													0	0	0	0.008291	0	11	36										A	123192861	G	A	123192861	3	1	13	1	0	0	0	0	1	0	0	0	8208	943	33	1	8360	1	KIAA1109	4	123192861	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	19964196	123192861	67961415	95	3285										
NR3C2	4306	broad.mit.edu	37	chr4	149357276	149357276	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtgcagggctgtgcgacctgGagcctcgattttcaacatta	12	10	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:149357276G>C	uc003ilj.3	-	2	1071	c.737C>G	c.(736-738)TCC>TGC	p.S246C	NR3C2_uc003ilk.3_Missense_Mutation_p.S246C|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	246	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GTGCGACCTGGAGCCTCGATT	0.537													0	0	0	0.021523	0	24	45										C	149357276	G	C	149357276	3	2	13	1	0	0	0	0	1	0	0	0	10631	1174	41	1	2249	1	NR3C2	4	149357276	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	26164415	149357276	41797000	96	3286										
FAM198B	51313	broad.mit.edu	37	chr4	159092463	159092463	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgctccagagcttacgcaccCgcgggacgcacagggagcag	14	14	0	1	rs148186776		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:159092463C>G	uc003ipp.3	-	2	517	c.65G>C	c.(64-66)CGG>CCG	p.R22P	uc003ipu.1_5'Flank|FAM198B_uc003ipq.3_Missense_Mutation_p.R22P|FAM198B_uc003ipr.3_Missense_Mutation_p.R22P|FAM198B_uc003ips.2_Missense_Mutation_p.R22P|uc003ipt.1_RNA	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	22	Cytoplasmic (Potential).					Golgi membrane|integral to membrane					0						CTTACGCACCCGCGGGACGCA	0.587													0	0	0	0.024245	0	14	54										G	159092463	C	G	159092463	3	3	13	1	0	0	0	0	1	0	0	0	5529	652	23	4	1615	4	FAM198B	4	159092463	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	9735187	159092463	32061813	97	3287										
RAPGEF2	9693	broad.mit.edu	37	chr4	160273906	160273906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcacagtgaaatttcttcacGatccagtattgttagcaatt	6	8	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:160273906G>A	uc003iqg.3	+	21	3762	c.3452G>A	c.(3451-3453)CGA>CAA	p.R1151Q		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1151	Ser-rich.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		ATTTCTTCACGATCCAGTATT	0.433													0	0	0	0.024334	0	24	50										A	160273906	G	A	160273906	3	1	13	1	0	0	0	0	1	0	0	0	13044	1058	37	1	3534	1	RAPGEF2	4	160273906	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1181443	160273906	30880370	98	3288										
HELT	391723	broad.mit.edu	37	chr4	185941474	185941474	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acttccactatggctaccacGagtgcatgaagaacctggtg	10	11	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:185941474G>C	uc011ckq.1	+	4	532	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	HELT_uc011cko.1_Missense_Mutation_p.E93Q|HELT_uc003ixa.3_Missense_Mutation_p.E92Q|HELT_uc011ckp.1_Missense_Mutation_p.E36Q	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	178	Orange.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		TGGCTACCACGAGTGCATGAA	0.577													0	0	0	0.027356	0	26	69										C	185941474	G	C	185941474	3	2	13	1	0	0	0	0	1	0	0	0	7048	1059	37	1	546	1	HELT	4	185941474	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	25667568	185941474	5212802	99	3289										
TRIML2	205860	broad.mit.edu	37	chr4	189026057	189026057	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gctgcttcaagtttctccctCgatgtgttcaatatttcctg	7	11	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr4:189026057C>G	uc003izl.2	-	2	105	c.69G>C	c.(67-69)TCG>TCC	p.S23S	TRIML2_uc011cle.1_Silent_p.S73S|TRIML2_uc011clf.1_Silent_p.S73S	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	23	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GTTTCTCCCTCGATGTGTTCA	0.403													0	0	0	0.027356	0	27	88										G	189026057	C	G	189026057	2	3	13	1	0	0	0	0	0	0	0	1	16548	871	31	1		1	TRIML2	4	189026057	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3084583	189026057	2128219	100	3290										
AMACR	23600	broad.mit.edu	37	chr5	34008107	34008107	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccggacagctccacgaccgaGatgccctgcagtgccatggc	12	16	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:34008107G>C	uc003jig.2	-	1	100	c.18C>G	c.(16-18)ATC>ATG	p.I6M	AMACR_uc003jih.2_Missense_Mutation_p.I6M|AMACR_uc003jii.2_Missense_Mutation_p.I6M|AMACR_uc003jij.2_Missense_Mutation_p.I6M|AMACR_uc003jil.1_Missense_Mutation_p.I6M|AMACR_uc003jik.1_Missense_Mutation_p.I6M	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	6					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						CCACGACCGAGATGCCCTGCA	0.672													0	0	0	0.021553	0	3	12										C	34008107	G	C	34008107	3	2	13	1	0	0	0	0	1	0	0	0	562	932	33	1	1480	1	AMACR	5	34008107	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		34008107	146907153	101	3291										
WDR70	55100	broad.mit.edu	37	chr5	37605251	37605251	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgcaaggcaaaaaagtcattCccactacgtgcacatatagt	7	10	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:37605251C>T	uc003jkv.2	+	10	1061	c.1003C>T	c.(1003-1005)CCC>TCC	p.P335S	WDR70_uc010iva.1_Missense_Mutation_p.P335S	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	335	WD 4.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAAGTCATTCCCACTACGTG	0.423													0	0	0	0.00308	0	8	77										T	37605251	C	T	37605251	3	4	13	1	0	0	0	0	1	0	0	0	17318	855	30	1	1041	1	WDR70	5	37605251	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3597144	37605251	143310009	102	3292										
FBXO4	26272	broad.mit.edu	37	chr5	41929935	41929935	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgtttggaccaggtttggaaGaattgaatacctctttggtg	12	5	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:41929935G>A	uc003jmq.2	+	3	618	c.562G>A	c.(562-564)GAA>AAA	p.E188K	FBXO4_uc003jmp.2_Missense_Mutation_p.E188K|FBXO4_uc003jmr.2_Missense_Mutation_p.E188K	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	188				E -> Q (in Ref. 1; AAF04468).	positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				AGGTTTGGAAGAATTGAATAC	0.418													0	0	0	0.01441	0	78	110										A	41929935	G	A	41929935	3	1	13	1	0	0	0	0	1	0	0	0	5748	943	33	1	572	1	FBXO4	5	41929935	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	4324684	41929935	138985325	103	3293										
HMGCS1	3157	broad.mit.edu	37	chr5	43295898	43295898	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atactatttttatctctattCtggtcattaaggaagtcatt	5	6	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:43295898C>T	uc003jnr.3	-	6	1068	c.861G>A	c.(859-861)CAG>CAA	p.Q287Q	HMGCS1_uc003jnp.3_5'Flank|HMGCS1_uc003jnq.3_Silent_p.Q287Q	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	287					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						TATCTCTATTCTGGTCATTAA	0.358													0	0	0	0.01441	0	59	72										T	43295898	C	T	43295898	2	4	13	1	0	0	0	0	0	0	0	1	7232	912	32	1		1	HMGCS1	5	43295898	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1365963	43295898	137619362	104	3294										
ANKRD34B	340120	broad.mit.edu	37	chr5	79855427	79855427	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttttgccttgcaagcactaaGaagaactttcagggtctctg	9	9	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:79855427G>A	uc010jam.2	-	4	762	c.412C>T	c.(412-414)CTT>TTT	p.L138F	ANKRD34B_uc003kgw.2_Missense_Mutation_p.L138F|ANKRD34B_uc010jan.2_Missense_Mutation_p.L138F	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	138	ANK 4.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		CAAGCACTAAGAAGAACTTTC	0.428													0	0	0	0.024245	0	16	174										A	79855427	G	A	79855427	3	1	13	1	0	0	0	0	1	0	0	0	663	942	33	1	1136	1	ANKRD34B	5	79855427	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	36559529	79855427	101059833	105	3295										
FAM174A	345757	broad.mit.edu	37	chr5	99897787	99897787	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aagaaaccgaaagactaggaGatatggagttttggacacta	11	5	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:99897787G>C	uc003knj.1	+	2	584	c.464G>C	c.(463-465)AGA>ACA	p.R155T		NM_198507	NP_940909	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	155	Cytoplasmic (Potential).					integral to membrane					0						AAGACTAGGAGATATGGAGTT	0.269													0	0	0	0.010729	0	12	33										C	99897787	G	C	99897787	3	2	13	1	0	0	0	0	1	0	0	0	5495	942	33	1	470	1	FAM174A	5	99897787	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	20042360	99897787	81017473	106	3296										
PRR16	51334	broad.mit.edu	37	chr5	120021694	120021694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctctgacctacagctggagGatgagatgactgacagctcc	11	12	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:120021694G>A	uc003ksq.2	+	2	368	c.205G>A	c.(205-207)GAT>AAT	p.D69N	PRR16_uc003ksp.2_Missense_Mutation_p.D46N|PRR16_uc003ksr.2_5'UTR	NM_016644	NP_057728	Q569H4	PRR16_HUMAN	proline rich 16	69	Potential.									pancreas(2)|ovary(1)	3		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		ACAGCTGGAGGATGAGATGAC	0.473													0	0	0	0.006214	0	10	46										A	120021694	G	A	120021694	3	1	13	1	0	0	0	0	1	0	0	0	12589	1174	41	1	142	1	PRR16	5	120021694	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	20123907	120021694	60893566	107	3297										
SLC22A4	6583	broad.mit.edu	37	chr5	131679478	131679478	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gatctgggaaaaaaacaagaGactcaatggagacagaagaa	11	5	2	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:131679478G>C	uc003kwq.2	+	10	1771	c.1606G>C	c.(1606-1608)GAC>CAC	p.D536H	uc003kwr.3_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	536	Cytoplasmic (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	AAAAACAAGAGACTCAATGGA	0.338													0	0	0	0.006214	0	9	41										C	131679478	G	C	131679478	3	2	13	1	0	0	0	0	1	0	0	0	14456	942	33	1	1644	1	SLC22A4	5	131679478	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	11657784	131679478	49235782	108	3298										
BRD8	10902	broad.mit.edu	37	chr5	137506551	137506551	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cattgcaaagctcatccagtCtgctgtccatgtgtccagct	8	13	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:137506551C>G	uc003lcf.1	-	6	465	c.410G>C	c.(409-411)AGA>ACA	p.R137T	BRD8_uc003lcc.1_RNA|BRD8_uc003lcg.2_Missense_Mutation_p.R137T|BRD8_uc003lci.2_Missense_Mutation_p.R137T|BRD8_uc003lch.2_5'UTR|BRD8_uc011cym.1_Missense_Mutation_p.R121T|BRD8_uc010jer.1_Missense_Mutation_p.R106T|BRD8_uc011cyn.1_Missense_Mutation_p.R96T|BRD8_uc010jes.1_Missense_Mutation_p.R4T	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	137	Potential.				cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTCATCCAGTCTGCTGTCCAT	0.403													0	0	0	0.01441	0	55	22										G	137506551	C	G	137506551	3	3	13	1	0	0	0	0	1	0	0	0	1506	913	32	1	3672	1	BRD8	5	137506551	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5827073	137506551	43408709	109	3299										
PCDHB2	56133	broad.mit.edu	37	chr5	140476448	140476448	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccgacttgctcaccgtctacCtggtggtggcgttggcctcg	13	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:140476448C>T	uc003lil.2	+	1	2212	c.2074C>T	c.(2074-2076)CTG>TTG	p.L692L	PCDHB2_uc003lim.1_Silent_p.L353L	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	692	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCGTCTACCTGGTGGTGGC	0.697													0	0	0	0.024334	0	10	181										T	140476448	C	T	140476448	2	4	13	1	0	0	0	0	0	0	0	1	11542	680	24	2		2	PCDHB2	5	140476448	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2969897	140476448	40438812	110	3300										
PCDHB3	56132	broad.mit.edu	37	chr5	140482301	140482301	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccgacttgctcaccgtctacCtggtggtggcattggcctcg	12	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:140482301C>T	uc003lio.2	+	1	2068	c.2068C>T	c.(2068-2070)CTG>TTG	p.L690L	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	690	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCGTCTACCTGGTGGTGGC	0.682													0	0	0	0.007413	0	7	132										T	140482301	C	T	140482301	2	4	13	1	0	0	0	0	0	0	0	1	11543	680	24	2		2	PCDHB3	5	140482301	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5853	140482301	40432959	111	3301										
PCDHB9	56127	broad.mit.edu	37	chr5	140567183	140567183	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaccgagagaagctgtgtggCcctaaagagccctgtatgct	13	10	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:140567183C>T	uc003liw.1	+	1	291	c.291C>T	c.(289-291)GGC>GGT	p.G97G		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	97	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCTGTGTGGCCCTAAAGAGC	0.458													0	0	0	0.015359	0	27	28										T	140567183	C	T	140567183	2	4	13	1	0	0	0	0	0	0	0	1	11549	726	26	2		2	PCDHB9	5	140567183	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	84882	140567183	40348077	112	3302										
PCDHGA4	56111	broad.mit.edu	37	chr5	140736303	140736303	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tccatcaactccaatacaggGatcctatatgctctttgctc	5	13	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:140736303G>A	uc003ljq.1	+	1	1536	c.1536G>A	c.(1534-1536)GGG>GGA	p.G512G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.G512G	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	512	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAATACAGGGATCCTATATG	0.527													0	0	0	0.013726	0	33	117										A	140736303	G	A	140736303	2	1	13	1	0	0	0	0	0	0	0	1	11556	1161	41	1		1	PCDHGA4	5	140736303	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	169120	140736303	40178957	113	3303										
PCDHGC3	5098	broad.mit.edu	37	chr5	140856170	140856170	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcgagagcgcgcacgatcccGatgtgggaagcaactcttta	12	11	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:140856170G>A	uc003lkv.1	+	1	602	c.487G>A	c.(487-489)GAT>AAT	p.D163N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.D163N|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	163	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACGATCCCGATGTGGGAAG	0.567													0	0	0	0.008871	0	18	55										A	140856170	G	A	140856170	3	1	13	1	0	0	0	0	1	0	0	0	11569	1058	37	1	489	1	PCDHGC3	5	140856170	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	119867	140856170	40059090	114	3304										
SPINK9	643394	broad.mit.edu	37	chr5	147715197	147715197	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgagagcaacagccatagtCctactcttggctctgacact	8	12	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:147715197C>G	uc003lpe.1	+	1	76	c.21C>G	c.(19-21)GTC>GTG	p.V7V	uc003lpb.1_Intron	NM_001040433	NP_001035523	Q5DT21	ISK9_HUMAN	serine peptidase inhibitor, Kazal type 9	7						extracellular region	protein binding|serine-type endopeptidase inhibitor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCCATAGTCCTACTCTTGG	0.483													0	0	0	0.014323	0	22	47										G	147715197	C	G	147715197	2	3	13	1	0	0	0	0	0	0	0	1	15065	842	30	1		1	SPINK9	5	147715197	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	6859027	147715197	33200063	115	3305										
CSF1R	1436	broad.mit.edu	37	chr5	149437110	149437110	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaagaagtggagacaggcctCatctccacataggtgtccac	11	11	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:149437110C>T	uc003lrl.2	-	15	2373	c.2178G>A	c.(2176-2178)ATG>ATA	p.M726I	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.M726I	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	726	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	AGACAGGCCTCATCTCCACAT	0.552													0	0	0	0.001984	0	7	22										T	149437110	C	T	149437110	3	4	13	1	0	0	0	0	1	0	0	0	3932	826	29	1	768	1	CSF1R	5	149437110	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1721913	149437110	31478150	116	3306										
NSD1	64324	broad.mit.edu	37	chr5	176721219	176721219	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgctacctgaaagacctcttGagagaactgactccaggccc	9	13	1	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:176721219G>C	uc003mfr.3	+	23	6988	c.6850G>C	c.(6850-6852)GAG>CAG	p.E2284Q	NSD1_uc003mft.3_Missense_Mutation_p.E2015Q|NSD1_uc011dfx.1_Missense_Mutation_p.E1932Q	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2284	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AAGACCTCTTGAGAGAACTGA	0.537			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.01441	0	42	111										C	176721219	G	C	176721219	3	2	13	1	0	0	0	0	1	0	0	0	10669	1291	45	1	6936	1	NSD1	5	176721219	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	27284109	176721219	4194041	117	3307										
GRM6	2916	broad.mit.edu	37	chr5	178410024	178410024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctcgttgaaggtctcgggcaCgccacgggccttgatggcgt	15	12	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr5:178410024C>T	uc003mjr.2	-	9	2502	c.2323G>A	c.(2323-2325)GTG>ATG	p.V775M	GRM6_uc003mjq.2_Missense_Mutation_p.V178M	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	775	Cytoplasmic (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GTCTCGGGCACGCCACGGGCC	0.597													0	0	0	0.00499	0	17	47										T	178410024	C	T	178410024	3	4	13	1	0	0	0	0	1	0	0	0	6801	536	19	2	318	2	GRM6	5	178410024	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1688805	178410024	2505236	118	3308										
HIVEP1	3096	broad.mit.edu	37	chr6	12164682	12164682	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gatgacgaggacaggcttgtGatagcaacctgatggatttt	13	6	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:12164682G>A	uc003nac.2	+	9	8324	c.8145G>A	c.(8143-8145)GTG>GTA	p.V2715V	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2715					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACAGGCTTGTGATAGCAACCT	0.448													0	0	0	0.008291	0	10	31										A	12164682	G	A	12164682	2	1	13	1	0	0	0	0	0	0	0	1	7186	1277	45	1		1	HIVEP1	6	12164682	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		12164682	158950385	119	3309										
HIST1H2BL	8340	broad.mit.edu	37	chr6	27775562	27775562	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgcttcagcaccttgtacacGtacacggagtagctctcctt	8	13	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:27775562G>C	uc003njl.2	-	1	148	c.123C>G	c.(121-123)TAC>TAG	p.Y41*	HIST1H3H_uc003njm.2_5'Flank	NM_003519	NP_003510	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	41					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCTTGTACACGTACACGGAGT	0.587													0	0	0	0.01441	0	61	130										C	27775562	G	C	27775562	4	2	13	1	0	0	0	0	0	1	0	0	7151	1140	40	4	261	4	HIST1H2BL	6	27775562	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	15610880	27775562	143339505	120	3310										
ZKSCAN3	80317	broad.mit.edu	37	chr6	28327555	28327555	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcaggcccccgcgaggcgctGagtcggctccgagagctctg	16	15	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:28327555G>A	uc003nle.3	+	2	408	c.192G>A	c.(190-192)CTG>CTA	p.L64L	ZKSCAN3_uc010jrc.2_Silent_p.L64L|ZKSCAN3_uc003nlf.3_Intron	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	64	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GCGAGGCGCTGAGTCGGCTCC	0.657													0	0	0	0.008361	0	30	67										A	28327555	G	A	28327555	2	1	13	1	0	0	0	0	0	0	0	1	17685	1277	45	1		1	ZKSCAN3	6	28327555	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	551993	28327555	142787512	121	3311										
ZFP57	346171	broad.mit.edu	37	chr6	29641454	29641454	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggcactggccggcccctctgCatgcaaggaagaccttgtca	12	14	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:29641454C>A	uc011dlw.1	-	4	585	c.434G>T	c.(433-435)TGC>TTC	p.C145F	ZFP57_uc003nnl.3_Missense_Mutation_p.C125F	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GGCCCCTCTGCATGCAAGGAA	0.552													1	0	1.56793e-16	0.01441	1.72874e-16	47	80										A	29641454	C	A	29641454	3	1	13	1	0	0	0	0	1	0	0	0	17648	710	25	4	1180	4	ZFP57	6	29641454	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1313899	29641454	141473613	122	3312										
CDKN1A	1026	broad.mit.edu	37	chr6	36652060	36652060	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caccgagacaccactggaggGtgacttcgcctgggagcgtg	15	12	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:36652060G>T	uc003omm.3	+	2	304	c.182G>T	c.(181-183)GGT>GTT	p.G61V	CDKN1A_uc011dtq.1_Missense_Mutation_p.G95V|CDKN1A_uc003oml.2_Missense_Mutation_p.G61V|CDKN1A_uc003omn.2_Missense_Mutation_p.G61V	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	61					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						CCACTGGAGGGTGACTTCGCC	0.672									Multiple_Endocrine_Neoplasia_type_1				1	0	2.61681e-11	0.020292	2.82879e-11	14	29										T	36652060	G	T	36652060	3	4	13	1	0	0	0	0	1	0	0	0	3158	1261	44	4	184	4	CDKN1A	6	36652060	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	7010606	36652060	134463007	123	3313										
CUL9	23113	broad.mit.edu	37	chr6	43155601	43155601	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agtatgggctgctgtctaatGaaccaagcagctcgtctact	10	10	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:43155601G>A	uc003ouk.2	+	7	1807	c.1732G>A	c.(1732-1734)GAA>AAA	p.E578K	CUL9_uc003ouj.1_Missense_Mutation_p.E468K|CUL9_uc003oul.2_Missense_Mutation_p.E578K|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_Missense_Mutation_p.E36K	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	578					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GCTGTCTAATGAACCAAGCAG	0.522													0	0	0	0.010504	0	20	41										A	43155601	G	A	43155601	3	1	13	1	0	0	0	0	1	0	0	0	4061	1291	45	1	1754	1	CUL9	6	43155601	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6503541	43155601	127959466	124	3314										
C6orf108	10591	broad.mit.edu	37	chr6	43194090	43194090	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcctgctgcagccactccagGtcctgctcatggatgagcct	11	15	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:43194090G>A	uc003ouo.2	-	2	257	c.240C>T	c.(238-240)GAC>GAT	p.D80D	C6orf108_uc003oup.2_Silent_p.D80D	NM_006443	NP_006434	O43598	RCL_HUMAN	putative c-Myc-responsive isoform 1	80					cell proliferation|deoxyribonucleoside monophosphate catabolic process|positive regulation of cell growth	cytoplasm|nucleus	deoxyribonucleoside 5'-monophosphate N-glycosidase activity|nucleoside deoxyribosyltransferase activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0123)|OV - Ovarian serous cystadenocarcinoma(102;0.0531)			GCCACTCCAGGTCCTGCTCAT	0.617													0	0	0	0.00308	0	7	31										A	43194090	G	A	43194090	2	1	13	1	0	0	0	0	0	0	0	1	2320	1252	44	2		2	C6orf108	6	43194090	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	38489	43194090	127920977	125	3315										
TJAP1	93643	broad.mit.edu	37	chr6	43472671	43472671	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caattcagcccagtcaggcaGcgccgggcgccccttggctg	13	16	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:43472671G>A	uc003ovd.2	+	11	1128	c.752G>A	c.(751-753)AGC>AAC	p.S251N	TJAP1_uc003ovf.2_Missense_Mutation_p.S241N|TJAP1_uc003ove.2_Missense_Mutation_p.S241N|TJAP1_uc003ovc.2_Missense_Mutation_p.S241N|TJAP1_uc010jyp.2_Missense_Mutation_p.S210N|TJAP1_uc011dvh.1_Missense_Mutation_p.S241N|TJAP1_uc003ovg.2_Missense_Mutation_p.S117N|TJAP1_uc011dvi.1_Missense_Mutation_p.S251N|TJAP1_uc011dvj.1_Missense_Mutation_p.S51N|TJAP1_uc003ovi.2_Missense_Mutation_p.S117N	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	251						Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CAGTCAGGCAGCGCCGGGCGC	0.642													0	0	0	0.01441	0	54	86										A	43472671	G	A	43472671	3	1	13	1	0	0	0	0	1	0	0	0	15925	971	34	2	782	2	TJAP1	6	43472671	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	278581	43472671	127642396	126	3316										
IMPG1	3617	broad.mit.edu	37	chr6	76720899	76720899	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttacctaaatcctaacacatGgatttttttgaatcctggaa	5	8	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:76720899G>T	uc003pik.1	-	8	980	c.850C>A	c.(850-852)CAT>AAT	p.H284N		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	284	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCTAACACATGGATTTTTTTG	0.313													1	0	1.58986e-06	0.008291	1.68109e-06	11	21										T	76720899	G	T	76720899	3	4	13	1	0	0	0	0	1	0	0	0	7728	1348	47	4	1583	4	IMPG1	6	76720899	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	33248228	76720899	94394168	127	3317										
GABRR2	2570	broad.mit.edu	37	chr6	89974215	89974215	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tccagcaccgagaggaacacGaacacaaagctgacccagag	10	13	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:89974215G>A	uc003pnb.2	-	8	1085	c.1077C>T	c.(1075-1077)TTC>TTT	p.F359F	GABRR2_uc011dzx.1_Silent_p.F235F	NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	359	Helical; (Potential).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		AGAGGAACACGAACACAAAGC	0.592													0	0	0	0.012319	0	23	29										A	89974215	G	A	89974215	2	1	13	1	0	0	0	0	0	0	0	1	6177	1049	37	1		1	GABRR2	6	89974215	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	13253316	89974215	81140852	128	3318										
BVES	11149	broad.mit.edu	37	chr6	105581450	105581450	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gggctggactctgtataattCattttgaaaattcctgtaaa	8	6	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:105581450C>A	uc003pqw.2	-	2	160	c.3G>T	c.(1-3)ATG>ATT	p.M1I	BVES_uc003pqx.2_Missense_Mutation_p.M1I|BVES_uc003pqy.2_Missense_Mutation_p.M1I	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	1	Extracellular (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				CTGTATAATTCATTTTGAAAA	0.323													1	0	1.06801e-11	0.009535	1.16101e-11	32	55										A	105581450	C	A	105581450	3	1	13	1	0	0	0	0	1	0	0	0	1575	826	29	3	1107	3	BVES	6	105581450	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	15607235	105581450	65533617	129	3319										
THEMIS	387357	broad.mit.edu	37	chr6	128040891	128040891	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcttcatccaccaaatcattCtgactaccaatcagtacttt	2	13	5	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:128040891C>G	uc003qbi.2	-	6	2155	c.1836G>C	c.(1834-1836)CAG>CAC	p.Q612H	THEMIS_uc010kfa.2_Missense_Mutation_p.Q515H|THEMIS_uc011ebt.1_Missense_Mutation_p.Q651H|THEMIS_uc010kfb.2_Missense_Mutation_p.Q577H	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	612					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CCAAATCATTCTGACTACCAA	0.443													0	0	0	0.027894	0	42	27										G	128040891	C	G	128040891	3	3	13	1	0	0	0	0	1	0	0	0	15857	912	32	1	97	1	THEMIS	6	128040891	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	22459441	128040891	43074176	130	3320										
STXBP5	134957	broad.mit.edu	37	chr6	147648368	147648368	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tggctctaatgatccttatcGgagagaaccccgatctcctc	8	13	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:147648368G>A	uc003qlz.2	+	18	2197	c.2036G>A	c.(2035-2037)CGG>CAG	p.R679Q	STXBP5_uc010khz.1_Missense_Mutation_p.R679Q|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.R350Q|STXBP5_uc003qma.2_Missense_Mutation_p.R26Q	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	679	WD 10.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GATCCTTATCGGAGAGAACCC	0.418													0	0	0	0.007291	0	28	57										A	147648368	G	A	147648368	3	1	13	1	0	0	0	0	1	0	0	0	15355	1116	39	2	2106	2	STXBP5	6	147648368	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	19607477	147648368	23466699	131	3321										
ULBP3	79465	broad.mit.edu	37	chr6	150387242	150387242	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gctctggacctcacaccactGttgcccatgtctgggcaaat	9	14	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:150387242G>A	uc003qns.3	-	2	145	c.145C>T	c.(145-147)CAG>TAG	p.Q49*	ULBP3_uc011eej.1_5'Flank|ULBP3_uc011eek.1_Intron	NM_024518	NP_078794	Q9BZM4	N2DL3_HUMAN	UL16 binding protein 3 precursor	49	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation	anchored to membrane|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.12)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.45e-12)		TCACACCACTGTTGCCCATGT	0.473													0	0	0	0.019004	0	34	63										A	150387242	G	A	150387242	4	1	13	1	0	0	0	0	0	1	0	0	16971	1386	48	2	600	2	ULBP3	6	150387242	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2738874	150387242	20727825	132	3322										
C6orf97	80129	broad.mit.edu	37	chr6	151914325	151914325	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggctttgacatgcggctggaCgtggttttagctcgaacaga	14	8	0	2	rs113968720		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:151914325C>A	uc003qol.2	+	8	1466	c.1377C>A	c.(1375-1377)GAC>GAA	p.D459E		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	459											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		TGCGGCTGGACGTGGTTTTAG	0.453													1	0	8.53417e-09	0.013726	9.12355e-09	33	32										A	151914325	C	A	151914325	3	1	13	1	0	0	0	0	1	0	0	0	2374	535	19	4	1407	4	C6orf97	6	151914325	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1527083	151914325	19200742	133	3323										
TFB1M	51106	broad.mit.edu	37	chr6	155579176	155579176	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtctgccaactctaacagccTgcccgtgctttccaagcgct	8	16	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr6:155579176T>C	uc003qqj.3	-	7	899	c.835A>G	c.(835-837)AGG>GGG	p.R279G	TFB1M_uc003qqk.2_Intron|uc003qqi.1_5'Flank	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		TCTAACAGCCTGCCCGTGCTT	0.453													0	0	0	0.007291	0	29	94										C	155579176	T	C	155579176	3	2	13	1	0	0	0	0	1	0	0	0	15790	1579	55	5	209	5	TFB1M	6	155579176	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	3664851	155579176	15535891	134	3324										
NUPL2	11097	broad.mit.edu	37	chr7	23236339	23236339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aataaatcaatggaggaacaGggtaaatgaactgaaaagtc	10	4	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:23236339G>A	uc003svu.2	+	5	822	c.563G>A	c.(562-564)AGG>AAG	p.R188K	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Missense_Mutation_p.R65K|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Missense_Mutation_p.R65K|NUPL2_uc011jyx.1_5'UTR	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	188					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						TGGAGGAACAGGGTAAATGAA	0.328													0	0	0	0.024334	0	25	40										A	23236339	G	A	23236339	3	1	13	1	0	0	0	0	1	0	0	0	10775	1000	35	2	581	2	NUPL2	7	23236339	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		23236339	135902324	135	3325										
OGDH	4967	broad.mit.edu	37	chr7	44739835	44739835	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggcaacttcttccacgtgctAcgacgccagatcctgctgcc	9	16	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:44739835A>G	uc003tln.2	+	19	2635	c.2526A>G	c.(2524-2526)CTA>CTG	p.L842L	OGDH_uc011kbx.1_Silent_p.L838L|OGDH_uc011kby.1_Silent_p.L692L|OGDH_uc003tlp.2_Silent_p.L853L|OGDH_uc011kbz.1_Silent_p.L637L	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	842					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCCACGTGCTACGACGCCAGA	0.567													0	0	0	0.012213	0	33	39										G	44739835	A	G	44739835	2	3	13	1	0	0	0	0	0	0	0	1	10839	378	14	5		5	OGDH	7	44739835	Silent	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	21503496	44739835	114398828	136	3326										
ABCA13	154664	broad.mit.edu	37	chr7	48314904	48314904	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caaatgaaagctcccgaatgGaaataactaggaaagtggtc	10	7	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:48314904G>C	uc003toq.2	+	17	5666	c.5641G>C	c.(5641-5643)GAA>CAA	p.E1881Q	ABCA13_uc010kyr.2_Missense_Mutation_p.E1384Q	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1881					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTCCCGAATGGAAATAACTAG	0.403													0	0	0	0.017118	0	38	58										C	48314904	G	C	48314904	3	2	13	1	0	0	0	0	1	0	0	0	31	1175	41	1	5536	1	ABCA13	7	48314904	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3575069	48314904	110823759	137	3327										
ABCA13	154664	broad.mit.edu	37	chr7	48315084	48315084	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aaactagggatagcatctctGaactctgtcctagtggttcc	9	10	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:48315084G>C	uc003toq.2	+	17	5846	c.5821G>C	c.(5821-5823)GAA>CAA	p.E1941Q	ABCA13_uc010kyr.2_Missense_Mutation_p.E1444Q	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1941					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TAGCATCTCTGAACTCTGTCC	0.338													0	0	0	0.01441	0	47	88										C	48315084	G	C	48315084	3	2	13	1	0	0	0	0	1	0	0	0	31	1291	45	1	5716	1	ABCA13	7	48315084	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	180	48315084	110823579	138	3328										
AKAP9	10142	broad.mit.edu	37	chr7	91630326	91630326	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctaggagaattacaagaacaGattgtgcaaaagaaccaaga	9	6	0	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:91630326G>C	uc003ulg.2	+	8	1320	c.1095G>C	c.(1093-1095)CAG>CAC	p.Q365H	AKAP9_uc003ule.2_Missense_Mutation_p.Q377H|AKAP9_uc003ulf.2_Missense_Mutation_p.Q365H|AKAP9_uc003uli.2_5'UTR	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	377	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			tacaagaacagattgtgcaaa	0.02			T	BRAF	papillary thyroid								0	0	0	0.004672	0	3	14										C	91630326	G	C	91630326	3	2	13	1	0	0	0	0	1	0	0	0	459	933	33	1	1125	1	AKAP9	7	91630326	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	43315242	91630326	67508337	139	3329										
TSC22D4	81628	broad.mit.edu	37	chr7	100075057	100075057	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cccgggatgtgcccgcactcTcaccggtctcaggctctggg	13	16	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:100075057T>A	uc003uva.2	-	2	1360	c.605A>T	c.(604-606)GAG>GTG	p.E202V	TSC22D4_uc003uvb.2_5'UTR|TSC22D4_uc011kjv.1_5'UTR|TSC22D4_uc010lgx.2_Missense_Mutation_p.E202V|TSC22D4_uc003uvc.3_Missense_Mutation_p.E202V	NM_030935	NP_112197	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	202					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCCGCACTCTCACCGGTCTC	0.711													0	0	0	0.008291	0	11	13										A	100075057	T	A	100075057	3	1	13	1	0	0	0	0	1	0	0	0	16607	1551	54	5	598	5	TSC22D4	7	100075057	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	8444731	100075057	59063606	140	3330										
SLC12A9	56996	broad.mit.edu	37	chr7	100458882	100458882	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgggcctcggcccccaacttCcggtgagagactcagatctg	12	14	2	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:100458882C>G	uc003uwp.2	+	10	1483	c.1341C>G	c.(1339-1341)TTC>TTG	p.F447L	SLC12A9_uc003uwq.2_Missense_Mutation_p.F358L|SLC12A9_uc011kki.1_5'UTR|SLC12A9_uc003uwr.2_Missense_Mutation_p.F183L|SLC12A9_uc003uws.2_5'UTR|SLC12A9_uc003uwt.2_Missense_Mutation_p.F183L|SLC12A9_uc003uwv.2_5'UTR	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	447	Cytoplasmic (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCCCCAACTTCCGGTGAGAGA	0.642													0	0	0	0.023175	0	35	110										G	100458882	C	G	100458882	3	3	13	1	0	0	0	0	1	0	0	0	14390	854	30	1	1375	1	SLC12A9	7	100458882	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	383825	100458882	58679781	141	3331										
SPDYE6	729597	broad.mit.edu	37	chr7	101989042	101989042	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agcaagggtatgcgagagcgGttcttcctatacaggaagtg	14	7	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:101989042G>T	uc011kkp.1	-	6	1252	c.831C>A	c.(829-831)AAC>AAA	p.N277K	SPDYE6_uc003uzb.2_Missense_Mutation_p.N133K	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	277	Arg-rich.										0						TGCGAGAGCGGTTCTTCCTAT	0.537													1	0	2.00703e-41	0.01441	2.23838e-41	51	447										T	101989042	G	T	101989042	3	4	13	1	0	0	0	0	1	0	0	0	15032	1252	44	4	385	4	SPDYE6	7	101989042	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1530160	101989042	57149621	142	3332										
DOCK4	9732	broad.mit.edu	37	chr7	111422961	111422961	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aatctttttgccatctacctCtcccattttcatgcagtccc	3	15	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:111422961C>T	uc003vfx.2	-	34	3786	c.3517G>A	c.(3517-3519)GAG>AAG	p.E1173K	DOCK4_uc011kml.1_Missense_Mutation_p.E54K|DOCK4_uc011kmm.1_Missense_Mutation_p.E80K|DOCK4_uc003vfw.2_Missense_Mutation_p.E623K|DOCK4_uc003vfy.2_Missense_Mutation_p.E1218K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1173	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CCATCTACCTCTCCCATTTTC	0.383													0	0	0	0.014323	0	24	73										T	111422961	C	T	111422961	3	4	13	1	0	0	0	0	1	0	0	0	4689	922	32	1	2459	1	DOCK4	7	111422961	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	9433919	111422961	47715702	143	3333										
TFEC	22797	broad.mit.edu	37	chr7	115580778	115580778	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgcagcactaaatgataaatCtgtgaagtatgacaaaggat	9	5	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:115580778C>G	uc003vhj.1	-	8	1055	c.871G>C	c.(871-873)GAT>CAT	p.D291H	TFEC_uc003vhk.1_Missense_Mutation_p.D262H|TFEC_uc003vhl.3_3'UTR|TFEC_uc011kmw.1_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	291	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			AATGATAAATCTGTGAAGTAT	0.433													0	0	0	0.01441	0	55	106										G	115580778	C	G	115580778	3	3	13	1	0	0	0	0	1	0	0	0	15799	913	32	1	176	1	TFEC	7	115580778	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	4157817	115580778	43557885	144	3334										
POT1	25913	broad.mit.edu	37	chr7	124475365	124475365	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	attgttccttgtataagaaaTggtgctgaaaggtccaaaag	10	5	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:124475365T>A	uc003vlm.2	-	15	2074	c.1473A>T	c.(1471-1473)CCA>CCT	p.P491P	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Silent_p.P360P|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	491					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						GTATAAGAAATGGTGCTGAAA	0.269													0	0	0	0.013114	0	47	87										A	124475365	T	A	124475365	2	1	13	1	0	0	0	0	0	0	0	1	12260	1451	51	5		5	POT1	7	124475365	Silent	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	8894587	124475365	34663298	145	3335										
TAS2R39	259285	broad.mit.edu	37	chr7	142880972	142880972	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctcaaactgaggtggagaaTtactggattgataccctggc	11	9	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:142880972T>C	uc011ksw.1	+	1	461	c.461T>C	c.(460-462)ATT>ACT	p.I154T		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	154	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					AGGTGGAGAATTACTGGATTG	0.433													0	0	0	0.019004	0	34	60										C	142880972	T	C	142880972	3	2	13	1	0	0	0	0	1	0	0	0	15573	1493	52	5	463	5	TAS2R39	7	142880972	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	18405607	142880972	16257691	146	3336										
ZNF786	136051	broad.mit.edu	37	chr7	148769089	148769089	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctccccgtgtgggccgccaGatggcgcagcagacacagct	13	16	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:148769089G>A	uc003wfh.2	-	4	912	c.775C>T	c.(775-777)CTG>TTG	p.L259L	ZNF786_uc011kuk.1_Silent_p.L222L|ZNF786_uc003wfi.2_Silent_p.L173L	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	259	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGGGCCGCCAGATGGCGCAGC	0.677													0	0	0	0.006214	0	10	19										A	148769089	G	A	148769089	2	1	13	1	0	0	0	0	0	0	0	1	18155	933	33	1		1	ZNF786	7	148769089	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	5888117	148769089	10369574	147	3337										
SSPO	23145	broad.mit.edu	37	chr7	149508033	149508033	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtgtgcccacccaggactgcCcctgtgcccacgaggggcac	13	17	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:149508033C>T	uc010lpk.2	+	67	9427	c.9427C>T	c.(9427-9429)CCC>TCC	p.P3143S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3143					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCAGGACTGCCCCTGTGCCCA	0.617													0	0	0	0.016723	0	13	24										T	149508033	C	T	149508033	3	4	13	1	0	0	0	0	1	0	0	0	15188	623	22	2	9683	2	SSPO	7	149508033	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	738944	149508033	9630630	148	3338										
SSPO	23145	broad.mit.edu	37	chr7	149509070	149509070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtggccctgcccggtgccatCggcaccggttctgtgccagg	15	15	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:149509070C>T	uc010lpk.2	+	69	9616	c.9616C>T	c.(9616-9618)CGG>TGG	p.R3206W		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3206	TSP type-1 11.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGGTGCCATCGGCACCGGTT	0.697													0	0	0	0.014323	0	23	28										T	149509070	C	T	149509070	3	4	13	1	0	0	0	0	1	0	0	0	15188	875	31	1	9880	1	SSPO	7	149509070	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1037	149509070	9629593	149	3339										
MLL3	58508	broad.mit.edu	37	chr7	152027735	152027735	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cagggagtttgccgattcctCagacacagatcgctgaagag	12	10	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:152027735C>T	uc003wla.2	-	3	559	c.340G>A	c.(340-342)GAG>AAG	p.E114K		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	114					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCCGATTCCTCAGACACAGAT	0.433			N		medulloblastoma								0	0	0	0.006122	0	17	84										T	152027735	C	T	152027735	3	4	13	1	0	0	0	0	1	0	0	0	9622	835	29	1	14623	1	MLL3	7	152027735	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2518665	152027735	7110928	150	3340										
DPP6	1804	broad.mit.edu	37	chr7	154561137	154561137	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttcccttagaggagattttGaagacacacatcgcacactg	8	10	0	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr7:154561137G>A	uc003wlk.2	+	9	1023	c.894G>A	c.(892-894)TTG>TTA	p.L298L	DPP6_uc003wli.2_Silent_p.L234L|DPP6_uc003wlm.2_Silent_p.L236L|DPP6_uc011kvq.1_Silent_p.L191L	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	298	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGGAGATTTTGAAGACACACA	0.507													0	0	0	0.021523	0	25	45										A	154561137	G	A	154561137	2	1	13	1	0	0	0	0	0	0	0	1	4730	1281	45	1		1	DPP6	7	154561137	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2533402	154561137	4577526	151	3341										
SPAG11B	10407	broad.mit.edu	37	chr8	7308697	7308697	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agatcctaaatgagggtcctCgagcctcccggtgagagatg	13	10	0	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:7308697C>T	uc003wrk.2	-	3	406	c.239G>A	c.(238-240)CGA>CAA	p.R80Q	SPAG11B_uc003wrg.1_Intron|SPAG11B_uc003wrh.1_Intron|SPAG11B_uc003wri.2_Missense_Mutation_p.R27Q|SPAG11B_uc003wrj.2_Intron|SPAG11B_uc003wrl.2_Intron	NM_016512	NP_057596	Q08648	SG11B_HUMAN	sperm associated antigen 11B isoform A	80					spermatogenesis	extracellular region					0				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		TGAGGGTCCTCGAGCCTCCCG	0.468													0	0	0	0.00499	0	17	29										T	7308697	C	T	7308697	3	4	13	1	0	0	0	0	1	0	0	0	14977	884	31	1	285	1	SPAG11B	8	7308697	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		7308697	139055325	152	3342										
INTS10	55174	broad.mit.edu	37	chr8	19690831	19690831	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctttgcgctaggggagtacaGagtgagtactgcacacatac	12	9	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:19690831G>C	uc003wzj.2	+	12	1660	c.1529G>C	c.(1528-1530)AGA>ACA	p.R510T		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	510					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		GGGGAGTACAGAGTGAGTACT	0.577													0	0	0	0.001984	0	7	21										C	19690831	G	C	19690831	3	2	13	1	0	0	0	0	1	0	0	0	7776	956	33	1	1575	1	INTS10	8	19690831	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12382134	19690831	126673191	153	3343										
ADAM28	10863	broad.mit.edu	37	chr8	24178763	24178763	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aatgagaatcaagatgagatCagaaagagggtatttgagat	12	2	2	6			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:24178763C>T	uc003xdy.2	+	8	764	c.681C>T	c.(679-681)ATC>ATT	p.I227I	ADAM28_uc003xdx.2_Silent_p.I227I|ADAM28_uc011kzz.1_5'UTR|ADAM28_uc011laa.1_Intron	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	227	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AAGATGAGATCAGAAAGAGGG	0.318													0	0	0	0.028581	0	14	67										T	24178763	C	T	24178763	2	4	13	1	0	0	0	0	0	0	0	1	246	816	29	1		1	ADAM28	8	24178763	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	4487932	24178763	122185259	154	3344										
EPHX2	2053	broad.mit.edu	37	chr8	27398124	27398124	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcctcagcaggatggtcactGaggaggaaatccagttctat	12	9	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:27398124G>A	uc003xfu.2	+	15	1411	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K	EPHX2_uc010luu.2_Missense_Mutation_p.E412K|EPHX2_uc010luv.2_Missense_Mutation_p.E378K|EPHX2_uc003xfv.2_Missense_Mutation_p.E391K|EPHX2_uc010luw.2_Missense_Mutation_p.E378K	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	444	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GATGGTCACTGAGGAGGAAAT	0.502													0	0	0	0.01892	0	24	34										A	27398124	G	A	27398124	3	1	13	1	0	0	0	0	1	0	0	0	5180	1291	45	1	1388	1	EPHX2	8	27398124	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3219361	27398124	118965898	155	3345										
MAK16	84549	broad.mit.edu	37	chr8	33346598	33346598	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	attcgacacaaatgtaagcaGagattcaccaagatcaccca	6	11	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:33346598G>A	uc003xjj.2	+	5	373	c.333G>A	c.(331-333)CAG>CAA	p.Q111Q	C8orf41_uc010lvu.1_Intron	NM_032509	NP_115898	Q9BXY0	MAK16_HUMAN	MAK16 homolog	111						nucleolus				ovary(1)	1						AATGTAAGCAGAGATTCACCA	0.353													0	0	0	0.023175	0	40	60										A	33346598	G	A	33346598	2	1	13	1	0	0	0	0	0	0	0	1	9198	933	33	1		1	MAK16	8	33346598	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	5948474	33346598	113017424	156	3346										
RAB11FIP1	80223	broad.mit.edu	37	chr8	37729146	37729146	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgtttatccaagcttgagctCttgccaagatgtggtttgtg	11	7	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:37729146C>G	uc003xkm.1	-	4	3218	c.3174G>C	c.(3172-3174)AAG>AAC	p.K1058N	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Missense_Mutation_p.K387N|RAB11FIP1_uc003xko.1_Missense_Mutation_p.K387N|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1058					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AGCTTGAGCTCTTGCCAAGAT	0.557													0	0	0	0.01441	0	56	98										G	37729146	C	G	37729146	3	3	13	1	0	0	0	0	1	0	0	0	12893	912	32	1	689	1	RAB11FIP1	8	37729146	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	4382548	37729146	108634876	157	3347										
FGFR1	2260	broad.mit.edu	37	chr8	38271717	38271717	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tccatgcggtgaccctccttCagcagcttgaaaagttcctc	8	14	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:38271717C>T	uc003xlp.2	-	17	3081	c.2139G>A	c.(2137-2139)CTG>CTA	p.L713L	FGFR1_uc010lwf.2_RNA|FGFR1_uc011lbo.1_Silent_p.L711L|FGFR1_uc011lbp.1_Silent_p.L624L|FGFR1_uc011lbq.1_Silent_p.L622L|FGFR1_uc010lwk.2_Silent_p.L703L	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	713	Cytoplasmic (Potential).|Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	GACCCTCCTTCAGCAGCTTGA	0.607		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						0	0	0	0.010504	0	22	28										T	38271717	C	T	38271717	2	4	13	1	0	0	0	0	0	0	0	1	5863	813	29	1		1	FGFR1	8	38271717	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	542571	38271717	108092305	158	3348										
PREX2	80243	broad.mit.edu	37	chr8	69046488	69046488	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caggtgttctttttcactttCagtcacttctgtcaccaaac	5	12	6	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:69046488C>T	uc003xxv.1	+	32	3988	c.3961C>T	c.(3961-3963)CAG>TAG	p.Q1321*		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1321					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTTTCACTTTCAGTCACTTCT	0.438													0	0	0	0.012319	0	17	25										T	69046488	C	T	69046488	4	4	13	1	0	0	0	0	0	1	0	0	12477	827	29	1	4316	1	PREX2	8	69046488	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	30774771	69046488	77317534	159	3349										
ZFHX4	79776	broad.mit.edu	37	chr8	77767490	77767490	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcttttaaagcagagtgttCtgaggatgtagagaatttaa	10	3	2	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:77767490C>T	uc003yav.2	+	10	8585	c.8198C>T	c.(8197-8199)TCT>TTT	p.S2733F	ZFHX4_uc003yau.1_Missense_Mutation_p.S2778F|ZFHX4_uc003yaw.1_Missense_Mutation_p.S2733F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2733						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAGAGTGTTCTGAGGATGTA	0.403										HNSCC(33;0.089)			0	0	0	0.020292	0	13	18										T	77767490	C	T	77767490	3	4	13	1	0	0	0	0	1	0	0	0	17632	913	32	1	8367	1	ZFHX4	8	77767490	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	8721002	77767490	68596532	160	3350										
FBXO43	286151	broad.mit.edu	37	chr8	101153669	101153669	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcattctcatcattaatgcaTaaactgctatcactaaagtc	4	10	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:101153669T>C	uc003yjd.2	-	2	1526	c.813A>G	c.(811-813)TTA>TTG	p.L271L	FBXO43_uc003yje.2_Silent_p.L237L|FBXO43_uc010mbp.1_Silent_p.L271L	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	271					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CATTAATGCATAAACTGCTAT	0.383													0	0	0	0.006122	0	19	38										C	101153669	T	C	101153669	2	2	13	1	0	0	0	0	0	0	0	1	5752	1403	49	5		5	FBXO43	8	101153669	Silent	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	23386179	101153669	45210353	161	3351										
EIF3E	3646	broad.mit.edu	37	chr8	109228656	109228656	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cttactgattcacattccctCagctttttctgagccccatc	4	15	3	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:109228656C>T	uc003ymu.2	-	9	964	c.936G>A	c.(934-936)CTG>CTA	p.L312L	EIF3E_uc003ymt.2_Silent_p.L263L|EIF3E_uc003ymv.2_Silent_p.L219L|EIF3E_uc010mci.1_Silent_p.L312L	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	312	PCI.			L->D: Promotes nuclear accumulation.	negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			CACATTCCCTCAGCTTTTTCT	0.289													0	0	0	0.006214	0	9	47										T	109228656	C	T	109228656	2	4	13	1	0	0	0	0	0	0	0	1	5015	813	29	1		1	EIF3E	8	109228656	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	8074987	109228656	37135366	162	3352										
EXT1	2131	broad.mit.edu	37	chr8	118816983	118816983	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtcccatcattgtctccttaTactgcttcttctgggtcact	6	13	5	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:118816983T>A	uc003yok.1	-	10	2806	c.2033A>T	c.(2032-2034)TAT>TTT	p.Y678F		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	678	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TGTCTCCTTATACTGCTTCTT	0.478			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				0	0	0	0.008361	0	31	58										A	118816983	T	A	118816983	3	1	13	1	0	0	0	0	1	0	0	0	5323	1406	49	5	215	5	EXT1	8	118816983	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	9588327	118816983	27547039	163	3353										
TIGD5	84948	broad.mit.edu	37	chr8	144681868	144681868	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgcgggggctagaaacagctCtgcggtggctggagaaccag	17	9	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr8:144681868C>G	uc003yyx.1	+	1	1648	c.1648C>G	c.(1648-1650)CTG>GTG	p.L550V	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	599					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			AGAAACAGCTCTGCGGTGGCT	0.687													0	0	0	0.00308	0	7	11										G	144681868	C	G	144681868	3	3	13	1	0	0	0	0	1	0	0	0	15896	912	32	1	1797	1	TIGD5	8	144681868	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	25864885	144681868	1682154	164	3354										
JAK2	3717	broad.mit.edu	37	chr9	5089767	5089767	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aaaagcttcagcatagtactGaagagcacctaagagacttt	8	8	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:5089767G>A	uc010mhm.2	+	19	2778	c.2665G>A	c.(2665-2667)GAA>AAA	p.E889K	JAK2_uc003ziw.2_Missense_Mutation_p.E889K	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	889	Protein kinase 2.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GCATAGTACTGAAGAGCACCT	0.448		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				0	0	0	0.014323	0	21	12										A	5089767	G	A	5089767	3	1	13	1	0	0	0	0	1	0	0	0	7938	1291	45	1	2735	1	JAK2	9	5089767	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		5089767	136123664	165	3355										
TRPM3	80036	broad.mit.edu	37	chr9	73233873	73233873	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtgtgcgcgatgaagtcgcgGtgtttggcagccacggcaag	17	9	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:73233873G>A	uc004aid.2	-	16	2476	c.2232C>T	c.(2230-2232)CAC>CAT	p.H744H	TRPM3_uc004ahu.2_Silent_p.H574H|TRPM3_uc004ahv.2_Silent_p.H546H|TRPM3_uc004ahw.2_Silent_p.H616H|TRPM3_uc004ahx.2_Silent_p.H603H|TRPM3_uc004ahy.2_Silent_p.H606H|TRPM3_uc004ahz.2_Silent_p.H593H|TRPM3_uc004aia.2_Silent_p.H591H|TRPM3_uc004aib.2_Silent_p.H581H|TRPM3_uc004aic.2_Silent_p.H744H	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	769	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TGAAGTCGCGGTGTTTGGCAG	0.612													0	0	0	0.006122	0	18	13										A	73233873	G	A	73233873	2	1	13	1	0	0	0	0	0	0	0	1	16584	1252	44	2		2	TRPM3	9	73233873	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	68144106	73233873	67979558	166	3356										
ECM2	1842	broad.mit.edu	37	chr9	95274343	95274343	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agtgatattatttttactcaGatcaagcctttccaaatttg	5	7	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:95274343G>A	uc004ash.2	-	5	1185	c.1120C>T	c.(1120-1122)CTG>TTG	p.L374L	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Silent_p.L352L|ECM2_uc011lty.1_Silent_p.L374L|ECM2_uc004asg.2_Silent_p.L352L	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	374	LRR 1.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						TTTTTACTCAGATCAAGCCTT	0.393													0	0	0	0.025465	0	35	15										A	95274343	G	A	95274343	2	1	13	1	0	0	0	0	0	0	0	1	4898	933	33	1		1	ECM2	9	95274343	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	22040470	95274343	45939088	167	3357										
CTNNAL1	8727	broad.mit.edu	37	chr9	111741687	111741687	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aagtcctccatacgctccaaGatgacttccaatgtcacaga	6	13	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:111741687G>C	uc004bdo.1	-	7	1017	c.975C>G	c.(973-975)ATC>ATG	p.I325M	CTNNAL1_uc010mts.1_Missense_Mutation_p.I61M|CTNNAL1_uc010mtt.1_Missense_Mutation_p.I325M|CTNNAL1_uc004bdp.1_Missense_Mutation_p.I325M	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	325					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		TACGCTCCAAGATGACTTCCA	0.443													0	0	0	0.027356	0	25	20										C	111741687	G	C	111741687	3	2	13	1	0	0	0	0	1	0	0	0	4015	932	33	1	1281	1	CTNNAL1	9	111741687	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	16467344	111741687	29471744	168	3358										
ENTPD2	954	broad.mit.edu	37	chr9	139945381	139945381	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcgctggccagcagcctctgGaggacctggtcacggccata	14	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:139945381G>C	uc004ckw.1	-	5	803	c.747C>G	c.(745-747)CTC>CTG	p.L249L	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Silent_p.L249L	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	249	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCAGCCTCTGGAGGACCTGGT	0.647													0	0	0	0.00308	0	8	14										C	139945381	G	C	139945381	2	2	13	1	0	0	0	0	0	0	0	1	5139	1161	41	1		1	ENTPD2	9	139945381	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	28203694	139945381	1268050	169	3359										
ENTPD2	954	broad.mit.edu	37	chr9	139945964	139945964	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gggcacaggcacactcacttGagcaggcgcatacccgctgt	12	14	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:139945964G>A	uc004ckw.1	-	3	440	c.384C>T	c.(382-384)CTC>CTT	p.L128L	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Silent_p.L128L	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	128	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		ACACTCACTTGAGCAGGCGCA	0.637													0	0	0	0.020292	0	13	25										A	139945964	G	A	139945964	2	1	13	1	0	0	0	0	0	0	0	1	5139	1277	45	1		1	ENTPD2	9	139945964	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	583	139945964	1267467	170	3360										
GRIN1	2902	broad.mit.edu	37	chr9	140058079	140058079	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtatcaggaatgtgactcgcGcagcaacgcccctgcgaccc	11	15	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr9:140058079G>C	uc004clk.2	+	17	2732	c.2402G>C	c.(2401-2403)CGC>CCC	p.R801P	GRIN1_uc004cli.1_Missense_Mutation_p.R476P|GRIN1_uc004clj.1_Missense_Mutation_p.R798P|GRIN1_uc004cll.2_Missense_Mutation_p.R801P|GRIN1_uc004clm.2_Missense_Mutation_p.R801P|GRIN1_uc004cln.2_Missense_Mutation_p.R819P|GRIN1_uc004clo.2_Missense_Mutation_p.R819P	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	801	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TGTGACTCGCGCAGCAACGCC	0.587													0	0	0	0.024245	0	14	8										C	140058079	G	C	140058079	3	2	13	1	0	0	0	0	1	0	0	0	6778	1087	38	4	2535	4	GRIN1	9	140058079	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	112115	140058079	1155352	171	3361										
ITIH2	3698	broad.mit.edu	37	chr10	7785117	7785117	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tatattttccagttgaaaatGacccacatttcatcatttat	3	8	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:7785117G>A	uc001ijs.2	+	17	2266	c.2104G>A	c.(2104-2106)GAC>AAC	p.D702N		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	702					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						AGTTGAAAATGACCCACATTT	0.313													0	0	0	0.01441	0	55	120										A	7785117	G	A	7785117	3	1	13	1	0	0	0	0	1	0	0	0	7904	1290	45	1	2170	1	ITIH2	10	7785117	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		7785117	127749630	172	3362										
FAM107B	83641	broad.mit.edu	37	chr10	14572359	14572359	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	attcataagaagttctctgtGaagatcttgatggttccggg	11	6	3	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:14572359G>C	uc001imx.1	-	2	345	c.100C>G	c.(100-102)CAC>GAC	p.H34D	FAM107B_uc001ina.1_Missense_Mutation_p.H209D|FAM107B_uc010qbu.1_RNA|FAM107B_uc009xjg.1_Missense_Mutation_p.H34D|FAM107B_uc001imy.1_Missense_Mutation_p.H34D|FAM107B_uc001imz.1_Missense_Mutation_p.H34D	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	34										breast(4)	4						AGTTCTCTGTGAAGATCTTGA	0.348													0	0	0	0.012213	0	34	57										C	14572359	G	C	14572359	3	2	13	1	0	0	0	0	1	0	0	0	5390	1290	45	1	307	1	FAM107B	10	14572359	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6787242	14572359	120962388	173	3363										
ARHGAP12	94134	broad.mit.edu	37	chr10	32197217	32197217	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcctgggagaagctagttttCtctacatccaagaactctgg	9	10	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:32197217C>A	uc001ivz.1	-	3	837	c.567G>T	c.(565-567)GAG>GAT	p.E189D	ARHGAP12_uc001ivy.1_Missense_Mutation_p.E187D|ARHGAP12_uc009xls.2_Missense_Mutation_p.E187D|ARHGAP12_uc001iwb.1_Missense_Mutation_p.E187D|ARHGAP12_uc001iwc.1_Missense_Mutation_p.E187D|ARHGAP12_uc009xlq.1_Missense_Mutation_p.E187D|ARHGAP12_uc001iwd.1_Missense_Mutation_p.E187D|ARHGAP12_uc009xlr.1_Missense_Mutation_p.E187D	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	189					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				AGCTAGTTTTCTCTACATCCA	0.433													1	0	1.61788e-16	0.012213	1.77875e-16	31	63										A	32197217	C	A	32197217	3	1	13	1	0	0	0	0	1	0	0	0	865	912	32	3	2045	3	ARHGAP12	10	32197217	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	17624858	32197217	103337530	174	3364										
FAM13C	220965	broad.mit.edu	37	chr10	61022288	61022288	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctccagaggagcttggctccGggcccgcagcttccggtttc	13	15	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:61022288G>A	uc001jkn.2	-	11	1276	c.1142C>T	c.(1141-1143)CCG>CTG	p.P381L	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Missense_Mutation_p.P298L|FAM13C_uc010qie.1_Missense_Mutation_p.P298L|FAM13C_uc010qif.1_Missense_Mutation_p.P403L|FAM13C_uc001jkp.2_Missense_Mutation_p.P298L	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	381										ovary(2)	2						GCTTGGCTCCGGGCCCGCAGC	0.542													0	0	0	0.00308	0	8	68										A	61022288	G	A	61022288	3	1	13	1	0	0	0	0	1	0	0	0	5454	1116	39	2	635	2	FAM13C	10	61022288	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	28825071	61022288	74512459	175	3365										
NRG3	10718	broad.mit.edu	37	chr10	84738833	84738833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaccagcatatcagcaactcGaagaatcaaggatcccagac	8	12	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:84738833G>A	uc001kco.2	+	8	1567	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K	NRG3_uc010qlz.1_Missense_Mutation_p.E513K|NRG3_uc001kcp.2_Missense_Mutation_p.E293K|NRG3_uc001kcq.2_Missense_Mutation_p.E164K|NRG3_uc001kcr.2_Missense_Mutation_p.E164K	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	514	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TCAGCAACTCGAAGAATCAAG	0.493													0	0	0	0.009096	0	4	33										A	84738833	G	A	84738833	3	1	13	1	0	0	0	0	1	0	0	0	10649	1059	37	1	1738	1	NRG3	10	84738833	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	23716545	84738833	50795914	176	3366										
IFIT3	3437	broad.mit.edu	37	chr10	91099496	91099496	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctgaaaagcaacaatcccatCagcgctactgcaaccttcag	6	14	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:91099496C>T	uc001kgf.2	+	2	1313	c.1084C>T	c.(1084-1086)CAG>TAG	p.Q362*	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Nonsense_Mutation_p.Q362*	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	362					type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						ACAATCCCATCAGCGCTACTG	0.433													0	0	0	0.027894	0	39	51										T	91099496	C	T	91099496	4	4	13	1	0	0	0	0	0	1	0	0	7524	827	29	1	1099	1	IFIT3	10	91099496	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	6360663	91099496	44435251	177	3367										
CCDC147	159686	broad.mit.edu	37	chr10	106139898	106139898	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agaactacaaggatgaggctCagaagcagagaaagatcatc	11	7	2	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:106139898C>A	uc001kyh.2	+	9	1419	c.1285C>A	c.(1285-1287)CAG>AAG	p.Q429K		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	429	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GGATGAGGCTCAGAAGCAGAG	0.493													1	0	3.27435e-08	0.020292	3.48125e-08	12	59										A	106139898	C	A	106139898	3	1	13	1	0	0	0	0	1	0	0	0	2781	827	29	3	1319	3	CCDC147	10	106139898	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	15040402	106139898	29394849	178	3368										
TACC2	10579	broad.mit.edu	37	chr10	123847305	123847305	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggatggagggtacagctgccCttcatggggacagcccagcc	15	12	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:123847305C>T	uc001lfv.2	+	4	5650	c.5290C>T	c.(5290-5292)CTT>TTT	p.L1764F	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.L1764F|TACC2_uc010qtv.1_Missense_Mutation_p.L1764F	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1764						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TACAGCTGCCCTTCATGGGGA	0.647													0	0	0	0.009096	0	4	8										T	123847305	C	T	123847305	3	4	13	1	0	0	0	0	1	0	0	0	15499	681	24	2	5300	2	TACC2	10	123847305	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	17707407	123847305	11687442	179	3369										
C10orf120	399814	broad.mit.edu	37	chr10	124457887	124457887	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggaatgtttctttttatactCcattgcttgtttgtagtccg	8	7	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:124457887C>G	uc001lgn.2	-	3	402	c.370G>C	c.(370-372)GAG>CAG	p.E124Q		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	124										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TTTTTATACTCCATTGCTTGT	0.438													0	0	0	0.01441	0	121	165										G	124457887	C	G	124457887	3	3	13	1	0	0	0	0	1	0	0	0	1590	864	30	1	641	1	C10orf120	10	124457887	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	610582	124457887	11076860	180	3370										
FAM175B	23172	broad.mit.edu	37	chr10	126505169	126505169	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccataaccatcagccttgttCaaaactttttaggtaagcca	5	11	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr10:126505169C>G	uc001lib.3	+	3	233	c.188C>G	c.(187-189)TCA>TGA	p.S63*		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	63	MPN-like.					BRISC complex	polyubiquitin binding				0						CAGCCTTGTTCAAAACTTTTT	0.323													0	0	0	0.013726	0	31	49										G	126505169	C	G	126505169	4	3	13	1	0	0	0	0	0	1	0	0	5498	838	29	1	198	1	FAM175B	10	126505169	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2047282	126505169	9029578	181	3371										
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5664543	5664543	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgggaagtggacgtgtccaaGaaaactgcctggatcctggg	15	8	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:5664543G>C	uc001mbf.2	+	14	2377	c.2133G>C	c.(2131-2133)AAG>AAC	p.K711N	HBG2_uc001mak.1_Intron|TRIM34_uc001mbh.2_Missense_Mutation_p.K357N|TRIM34_uc009yeq.2_Missense_Mutation_p.K112N|TRIM34_uc001mbi.2_Missense_Mutation_p.K357N|TRIM78P_uc009yer.2_Intron	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	711						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ACGTGTCCAAGAAAACTGCCT	0.408													0	0	0	0.016522	0	22	12										C	5664543	G	C	5664543	3	2	13	1	0	0	0	0	1	0	0	0	16531	933	33	1	2160	1	TRIM6-TRIM34	11	5664543	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		5664543	129341973	182	3372										
PDE3B	5140	broad.mit.edu	37	chr11	14825541	14825541	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcaaatctactgactatcccGaagcaaaggtcatcttctgt	6	11	5	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:14825541G>A	uc001mln.2	+	5	1820	c.1467G>A	c.(1465-1467)CCG>CCA	p.P489P	PDE3B_uc010rcr.1_Silent_p.P438P	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	489					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						TGACTATCCCGAAGCAAAGGT	0.353													0	0	0	0.020292	0	14	20										A	14825541	G	A	14825541	2	1	13	1	0	0	0	0	0	0	0	1	11638	1045	37	1		1	PDE3B	11	14825541	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	9160998	14825541	120180975	183	3373										
UEVLD	55293	broad.mit.edu	37	chr11	18586472	18586472	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gctaatgtgcaggcaataccGagttctccacctccaaccac	7	15	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:18586472G>A	uc001mot.2	-	6	659	c.579C>T	c.(577-579)CTC>CTT	p.L193L	UEVLD_uc001mou.2_Silent_p.L193L|UEVLD_uc010rde.1_Silent_p.L63L|UEVLD_uc010rdf.1_Silent_p.L171L|UEVLD_uc010rdg.1_Silent_p.L63L|UEVLD_uc001mov.2_Silent_p.L171L|UEVLD_uc010rdh.1_Silent_p.L193L	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	193	NAD (By similarity).				cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						AGGCAATACCGAGTTCTCCAC	0.373													0	0	0	0.00499	0	17	11										A	18586472	G	A	18586472	2	1	13	1	0	0	0	0	0	0	0	1	16930	1045	37	1		1	UEVLD	11	18586472	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3760931	18586472	116420044	184	3374										
CAT	847	broad.mit.edu	37	chr11	34492549	34492549	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctgactacgggagccacatCcaggctcttctggacaagta	10	13	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:34492549C>G	uc001mvm.2	+	12	1562	c.1479C>G	c.(1477-1479)ATC>ATG	p.I493M	CAT_uc001mvn.2_Missense_Mutation_p.I102M	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	493					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	GGAGCCACATCCAGGCTCTTC	0.507													0	0	0	0.01441	0	67	57										G	34492549	C	G	34492549	3	3	13	1	0	0	0	0	1	0	0	0	2686	845	30	1	1525	1	CAT	11	34492549	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	15906077	34492549	100513967	185	3375										
OR9Q2	219957	broad.mit.edu	37	chr11	57958523	57958523	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctccctcctctattaaaactCtcctgtggggacagctacac	6	15	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:57958523C>G	uc010rka.1	+	1	561	c.561C>G	c.(559-561)CTC>CTG	p.L187L		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				TATTAAAACTCTCCTGTGGGG	0.448													0	0	0	0.013537	0	12	31										G	57958523	C	G	57958523	2	3	13	1	0	0	0	0	0	0	0	1	11256	900	32	1		1	OR9Q2	11	57958523	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	23465974	57958523	77047993	186	3376										
OR5B2	390190	broad.mit.edu	37	chr11	58189810	58189810	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gttaaaattccaaacttataGaaatttttgccttctcaaca	3	8	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:58189810G>A	uc010rkg.1	-	1	925	c.925C>T	c.(925-927)CTA>TTA	p.L309L		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CAAACTTATAGAAATTTTTGC	0.383													0	0	0	0.010504	0	21	32										A	58189810	G	A	58189810	2	1	13	1	0	0	0	0	0	0	0	1	11150	933	33	1		1	OR5B2	11	58189810	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	231287	58189810	76816706	187	3377										
CCDC86	79080	broad.mit.edu	37	chr11	60609623	60609623	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tacaccgttaaggcgcagccGacggctgggaggcctaaggc	15	12	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:60609623G>A	uc001nqa.2	+	1	195	c.26G>A	c.(25-27)CGA>CAA	p.R9Q	CCDC86_uc001nqb.2_5'UTR	NM_024098	NP_077003	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	9					interspecies interaction between organisms	nucleus					0						AGGCGCAGCCGACGGCTGGGA	0.637													0	0	0	0.009096	0	3	19										A	60609623	G	A	60609623	3	1	13	1	0	0	0	0	1	0	0	0	2861	1058	37	1	28	1	CCDC86	11	60609623	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2419813	60609623	74396893	188	3378										
SLC22A10	387775	broad.mit.edu	37	chr11	63066993	63066993	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttattattgaaggttgtaaGatccaccatgcaggaggagc	11	6	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:63066993G>A	uc009yor.2	+	6	1170	c.962G>A	c.(961-963)AGA>AAA	p.R321K	SLC22A10_uc010rmo.1_RNA|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Missense_Mutation_p.R161K	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	321	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						AAGGTTGTAAGATCCACCATG	0.423													0	0	0	0.010729	0	10	22										A	63066993	G	A	63066993	3	1	13	1	0	0	0	0	1	0	0	0	14441	942	33	1	984	1	SLC22A10	11	63066993	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2457370	63066993	71939523	189	3379										
KLC2	64837	broad.mit.edu	37	chr11	66030506	66030506	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acatcctggcactggtctatCggtgaggactctctgggggt	14	10	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:66030506C>A	uc010rov.1	+	5	994	c.751C>A	c.(751-753)CGG>AGG	p.R251R	KLC2_uc010row.1_Silent_p.R251R|KLC2_uc009yra.2_Silent_p.R251R|KLC2_uc001ohb.2_Silent_p.R251R|KLC2_uc010rox.1_Silent_p.R174R|KLC2_uc001ohc.2_Silent_p.R251R|KLC2_uc001ohd.2_Silent_p.R174R|KLC2_uc001ohe.1_Silent_p.R112R	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	251	TPR 2.				blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						ACTGGTCTATCGGTGAGGACT	0.602													1	0	2.7689e-08	0.001984	2.95196e-08	7	21										A	66030506	C	A	66030506	2	1	13	1	0	0	0	0	0	0	0	1	8334	898	31	3		3	KLC2	11	66030506	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2963513	66030506	68976010	190	3380										
CD248	57124	broad.mit.edu	37	chr11	66082600	66082600	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaatggggatgtgtagggctGatgggtgaggtctggttagt	20	2	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:66082600G>A	uc001ohm.1	-	1	1916	c.1899C>T	c.(1897-1899)ATC>ATT	p.I633I		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	633	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GTGTAGGGCTGATGGGTGAGG	0.632													0	0	0	0.016522	0	24	42										A	66082600	G	A	66082600	2	1	13	1	0	0	0	0	0	0	0	1	2989	1280	45	1		1	CD248	11	66082600	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	52094	66082600	68923916	191	3381										
SYT12	91683	broad.mit.edu	37	chr11	66816082	66816082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctctccgcgtgacggtggctGagagcagcagcgacggccgt	16	13	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:66816082G>A	uc009yrl.2	+	8	1350	c.1120G>A	c.(1120-1122)GAG>AAG	p.E374K	SYT12_uc001oju.2_Missense_Mutation_p.E374K	NM_177963	NP_808878	Q8IV01	SYT12_HUMAN	synaptotagmin XII	374	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane				ovary(1)	1						GACGGTGGCTGAGAGCAGCAG	0.607													0	0	0	0.010504	0	18	40										A	66816082	G	A	66816082	3	1	13	1	0	0	0	0	1	0	0	0	15465	1291	45	1	1146	1	SYT12	11	66816082	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	733482	66816082	68190434	192	3382										
KDM2A	22992	broad.mit.edu	37	chr11	67021049	67021049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaatcaaggaccctcaaattCgggacttgcttactccaccg	8	13	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:67021049C>T	uc001ojw.2	+	19	3922	c.3058C>T	c.(3058-3060)CGG>TGG	p.R1020W	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Missense_Mutation_p.R714W|KDM2A_uc001ojz.1_Missense_Mutation_p.R478W|KDM2A_uc001oka.2_Missense_Mutation_p.R144W	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	1020					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						CCCTCAAATTCGGGACTTGCT	0.552													0	0	0	0.01441	0	59	76										T	67021049	C	T	67021049	3	4	13	1	0	0	0	0	1	0	0	0	8124	875	31	1	3128	1	KDM2A	11	67021049	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	204967	67021049	67985467	193	3383										
NUMA1	4926	broad.mit.edu	37	chr11	71719867	71719867	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctggaatttgcccaggtctcGaagctgctggtctgcatggg	14	10	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:71719867G>A	uc001orl.1	-	20	5255	c.5083C>T	c.(5083-5085)CGA>TGA	p.R1695*	NUMA1_uc001orj.2_5'UTR|NUMA1_uc009ysw.1_Nonsense_Mutation_p.R1244*|NUMA1_uc001ork.1_Nonsense_Mutation_p.R559*|NUMA1_uc001orm.1_Nonsense_Mutation_p.R1681*|NUMA1_uc001orn.2_Nonsense_Mutation_p.R1258*	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1695	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCCAGGTCTCGAAGCTGCTGG	0.582			T	RARA	APL								0	0	0	0.028581	0	17	80										A	71719867	G	A	71719867	4	1	13	1	0	0	0	0	0	1	0	0	10750	1066	37	1	1296	1	NUMA1	11	71719867	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	4698818	71719867	63286649	194	3384										
NUMA1	4926	broad.mit.edu	37	chr11	71728852	71728852	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggcatcctgtagctgctgcaGatgactggcaaactcccgca	11	13	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:71728852G>A	uc001orl.1	-	13	1172	c.1000C>T	c.(1000-1002)CTG>TTG	p.L334L	NUMA1_uc009ysw.1_5'Flank|NUMA1_uc001ork.1_Silent_p.L334L|NUMA1_uc001orm.1_Silent_p.L334L|NUMA1_uc001orn.2_5'Flank|NUMA1_uc009ysx.1_Silent_p.L334L|NUMA1_uc001oro.1_Silent_p.L334L|NUMA1_uc009ysy.1_Silent_p.L334L|NUMA1_uc001orp.2_Silent_p.L334L|NUMA1_uc001orq.2_Silent_p.L334L	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	334	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						AGCTGCTGCAGATGACTGGCA	0.602			T	RARA	APL								0	0	0	0.028581	0	16	28										A	71728852	G	A	71728852	2	1	13	1	0	0	0	0	0	0	0	1	10750	933	33	1		1	NUMA1	11	71728852	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	8985	71728852	63277664	195	3385										
MAP6	4135	broad.mit.edu	37	chr11	75298211	75298211	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctgggaccttgagtcttcaGaggttcagggactgcaggac	14	10	3	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:75298211G>C	uc001owu.2	-	4	2400	c.2335C>G	c.(2335-2337)CTG>GTG	p.L779V		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	779	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TGAGTCTTCAGAGGTTCAGGG	0.532													0	0	0	0.021022	0	37	55										C	75298211	G	C	75298211	3	2	13	1	0	0	0	0	1	0	0	0	9264	933	33	1	110	1	MAP6	11	75298211	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3569359	75298211	59708305	196	3386										
MYO7A	4647	broad.mit.edu	37	chr11	76873170	76873170	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccctgtgcccctgcagctttGagcagctctgcatcaacttc	8	16	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:76873170G>C	uc001oyb.2	+	13	1620	c.1348G>C	c.(1348-1350)GAG>CAG	p.E450Q	MYO7A_uc010rsl.1_Missense_Mutation_p.E450Q|MYO7A_uc010rsm.1_Missense_Mutation_p.E439Q|MYO7A_uc001oyc.2_Missense_Mutation_p.E450Q	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	450	Myosin head-like.		E -> Q (in USH1B).		actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CTGCAGCTTTGAGCAGCTCTG	0.572													0	0	0	0.004672	0	3	5										C	76873170	G	C	76873170	3	2	13	1	0	0	0	0	1	0	0	0	10082	1291	45	1	1394	1	MYO7A	11	76873170	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1574959	76873170	58133346	197	3387										
DLG2	1740	broad.mit.edu	37	chr11	83770465	83770465	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cttccttcagggcttccaccGctttactgtgggaaacctct	8	14	2	0	rs146925269		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:83770465G>T	uc001paj.2	-	6	800	c.497C>A	c.(496-498)GCG>GAG	p.A166E	DLG2_uc001pai.2_Missense_Mutation_p.A115E|DLG2_uc010rsy.1_Missense_Mutation_p.A133E|DLG2_uc010rsz.1_Missense_Mutation_p.A166E|DLG2_uc010rta.1_Missense_Mutation_p.A166E|DLG2_uc001pak.2_Missense_Mutation_p.A271E|DLG2_uc010rtb.1_Missense_Mutation_p.A133E|DLG2_uc001pal.1_Missense_Mutation_p.A166E|DLG2_uc001pam.1_Missense_Mutation_p.A205E	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	166	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GGCTTCCACCGCTTTACTGTG	0.478													1	0	0.000602214	0.014758	0.000618188	5	43										T	83770465	G	T	83770465	3	4	13	1	0	0	0	0	1	0	0	0	4555	1087	38	4	2237	4	DLG2	11	83770465	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6897295	83770465	51236051	198	3388										
ZC3H12C	85463	broad.mit.edu	37	chr11	110035800	110035800	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aggagaatttgaagtgtcaaCacatgcaccctcacagccgc	9	12	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:110035800C>A	uc009yxw.2	+	6	2041	c.1990C>A	c.(1990-1992)CAC>AAC	p.H664N	ZC3H12C_uc010rwc.1_Missense_Mutation_p.H665N|ZC3H12C_uc010rwd.1_Missense_Mutation_p.H665N|ZC3H12C_uc001pkr.3_Missense_Mutation_p.H633N	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	664							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		GAAGTGTCAACACATGCACCC	0.522													1	0	2.08403e-16	0.01441	2.28476e-16	57	57										A	110035800	C	A	110035800	3	1	13	1	0	0	0	0	1	0	0	0	17560	478	17	4	2012	4	ZC3H12C	11	110035800	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	26265335	110035800	24970716	199	3389										
TREH	11181	broad.mit.edu	37	chr11	118529682	118529682	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gatccaattctgagccagctGgaaagccacttcctgggccc	10	14	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:118529682G>A	uc001pty.1	-	13	1522	c.1477C>T	c.(1477-1479)CAG>TAG	p.Q493*	TREH_uc009zaj.1_Nonsense_Mutation_p.Q462*|TREH_uc001ptz.1_Nonsense_Mutation_p.Q370*	NM_007180	NP_009111	O43280	TREA_HUMAN	trehalase precursor	493					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			pancreas(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		TGAGCCAGCTGGAAAGCCACT	0.577											OREG0021385	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	52	42										A	118529682	G	A	118529682	4	1	13	1	0	0	0	0	0	1	0	0	16466	1357	47	2	285	2	TREH	11	118529682	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	8493882	118529682	16476834	200	3390										
SRPR	6734	broad.mit.edu	37	chr11	126138751	126138751	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccgggaattcaggccgcgttCgccgccgcttcctgctgcgc	13	17	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr11:126138751C>T	uc001qdh.2	-	1	1	c.-50_splice	c.e1-1		SRPR_uc010sbm.1_Splice_Site|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank|FOXRED1_uc001qdk.2_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor						SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		AGGCCGCGTTCGCCGCCGCTT	0.677													0	0	0	0.006214	0	10	12										T	126138751	C	T	126138751	5	4	13	1	0	0	0	0	0	0	1	0	15161	899	31	1		1	SRPR	11	126138751	Splice_Site	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	7609069	126138751	8867765	201	3391										
C1RL	51279	broad.mit.edu	37	chr12	7249214	7249214	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	catattgtcagaaaacacctCgggtctctgtctcttttgga	8	10	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:7249214C>T	uc001qsn.2	-	6	1254	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	C1RL_uc009zft.2_3'UTR	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	413	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						GAAAACACCTCGGGTCTCTGT	0.552													0	0	0	0.01441	0	63	130										T	7249214	C	T	7249214	3	4	13	1	0	0	0	0	1	0	0	0	1973	893	31	1	230	1	C1RL	12	7249214	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		7249214	126602681	202	3392										
PLEKHA5	54477	broad.mit.edu	37	chr12	19407999	19407999	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gactgttgcaaccatgacatCtgaagaaaagaaggaacggc	11	8	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:19407999C>T	uc001reb.2	+	5	418	c.332C>T	c.(331-333)TCT>TTT	p.S111F	PLEKHA5_uc010sie.1_Missense_Mutation_p.S111F|PLEKHA5_uc001rea.2_Missense_Mutation_p.S111F|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc010sif.1_Missense_Mutation_p.S3F|PLEKHA5_uc010sig.1_Missense_Mutation_p.S3F|PLEKHA5_uc010sih.1_Missense_Mutation_p.S3F	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	111							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACCATGACATCTGAAGAAAAG	0.378													0	0	0	0.008291	0	10	63										T	19407999	C	T	19407999	3	4	13	1	0	0	0	0	1	0	0	0	12059	913	32	1	350	1	PLEKHA5	12	19407999	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	12158785	19407999	114443896	203	3393										
GYS2	2998	broad.mit.edu	37	chr12	21721862	21721862	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcagaaaccgtggtgaacaCgtgagcgcaatgaacggaag	13	8	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:21721862C>T	uc001rfb.2	-	5	1015	c.760G>A	c.(760-762)GTG>ATG	p.V254M		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	254					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						GTGGTGAACACGTGAGCGCAA	0.428													0	0	0	0.009535	0	30	53										T	21721862	C	T	21721862	3	4	13	1	0	0	0	0	1	0	0	0	6913	536	19	2	1399	2	GYS2	12	21721862	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2313863	21721862	112130033	204	3394										
SYT10	341359	broad.mit.edu	37	chr12	33532824	33532824	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgataggccagcatttcattCcagtggtctcgcccaagacc	9	13	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:33532824C>G	uc001rll.1	-	6	1740	c.1443G>C	c.(1441-1443)TGG>TGC	p.W481C	SYT10_uc009zju.1_Missense_Mutation_p.W291C	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	481	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GCATTTCATTCCAGTGGTCTC	0.463													0	0	0	0.00874	0	42	78										G	33532824	C	G	33532824	3	3	13	1	0	0	0	0	1	0	0	0	15463	856	30	1	136	1	SYT10	12	33532824	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	11810962	33532824	100319071	205	3395										
OR10AD1	121275	broad.mit.edu	37	chr12	48596451	48596451	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agtgagcaccatggggctgaGaattaccacgatggcatcgg	14	9	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:48596451G>A	uc001rrl.1	-	1	625	c.625C>T	c.(625-627)CTC>TTC	p.L209F		NM_001004134	NP_001004134	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGGGGCTGAGAATTACCACG	0.537													0	0	0	0.016723	0	14	28										A	48596451	G	A	48596451	3	1	13	1	0	0	0	0	1	0	0	0	10896	942	33	1	332	1	OR10AD1	12	48596451	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	15063627	48596451	85255444	206	3396										
KRT74	121391	broad.mit.edu	37	chr12	52967248	52967248	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgcccccaggtgggcacacaGacaaacatgcaggccccagg	12	15	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:52967248G>A	uc001sap.1	-	1	362	c.314C>T	c.(313-315)TCT>TTT	p.S105F		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	105	Head.|Gly-rich.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		TGGGCACACAGACAAACATGC	0.637													0	0	0	0.015359	0	35	48										A	52967248	G	A	52967248	3	1	13	1	0	0	0	0	1	0	0	0	8487	942	33	1	1311	1	KRT74	12	52967248	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	4370797	52967248	80884647	207	3397										
MDM2	4193	broad.mit.edu	37	chr12	69207366	69207366	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccattgcttttgaagttattAaagtctgttggtgcacaaaa	8	6	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:69207366A>G	uc001sui.2	+	3	419	c.132A>G	c.(130-132)TTA>TTG	p.L44L	MDM2_uc009zri.2_Silent_p.L44L|MDM2_uc009zqx.2_Silent_p.L44L|MDM2_uc009zqw.2_Silent_p.L44L|MDM2_uc001suk.2_Silent_p.L44L|MDM2_uc009zqy.1_Silent_p.L33L|MDM2_uc001sun.3_Silent_p.L33L|MDM2_uc009zqz.2_Silent_p.L38L|MDM2_uc009zra.2_Silent_p.L38L|MDM2_uc009zrb.1_RNA|MDM2_uc001sum.1_Silent_p.L33L|MDM2_uc009zrd.2_Intron|MDM2_uc009zrc.2_5'UTR|MDM2_uc009zre.2_Silent_p.L33L|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Intron|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Intron	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	38	Necessary for interaction with USP2.|SWIB.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TGAAGTTATTAAAGTCTGTTG	0.353			A		sarcoma|glioma|colorectal|other								0	0	0	0.01441	0	45	80										G	69207366	A	G	69207366	2	3	13	1	0	0	0	0	0	0	0	1	9413	359	13	5		5	MDM2	12	69207366	Silent	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	16240118	69207366	64644529	208	3398										
PTPRB	5787	broad.mit.edu	37	chr12	70986212	70986212	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttccttgatggtccctttgtGagacagggtgatattgtaag	12	6	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:70986212G>A	uc001swb.3	-	5	1006	c.976C>T	c.(976-978)CAC>TAC	p.H326Y	PTPRB_uc010sto.1_Missense_Mutation_p.H326Y|PTPRB_uc010stp.1_Missense_Mutation_p.H326Y|PTPRB_uc001swc.3_Missense_Mutation_p.H544Y|PTPRB_uc001swa.3_Missense_Mutation_p.H544Y|PTPRB_uc001swd.3_Missense_Mutation_p.H543Y|PTPRB_uc009zrr.1_Missense_Mutation_p.H423Y|PTPRB_uc001swe.2_Missense_Mutation_p.H544Y	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	326	Fibronectin type-III 4.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTCCCTTTGTGAGACAGGGTG	0.418													0	0	0	0.021553	0	6	47										A	70986212	G	A	70986212	3	1	13	1	0	0	0	0	1	0	0	0	12796	1290	45	1	5129	1	PTPRB	12	70986212	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1778846	70986212	62865683	209	3399										
RASSF9	9182	broad.mit.edu	37	chr12	86199359	86199359	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcatgtagtttgctgggctGagctcccacaatttttctgt	9	9	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:86199359G>A	uc001taf.1	-	2	768	c.429C>T	c.(427-429)CTC>CTT	p.L143L		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	143					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TTGCTGGGCTGAGCTCCCACA	0.398													0	0	0	0.01441	0	88	135										A	86199359	G	A	86199359	2	1	13	1	0	0	0	0	0	0	0	1	13093	1277	45	1		1	RASSF9	12	86199359	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	15213147	86199359	47652536	210	3400										
USP44	84101	broad.mit.edu	37	chr12	95918479	95918479	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aatcgtttgaggtgcagtctGagaacctgaggtaggtggca	15	6	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:95918479G>C	uc001teg.2	-	4	1854	c.1710C>G	c.(1708-1710)CTC>CTG	p.L570L	USP44_uc001teh.2_Silent_p.L570L|USP44_uc009zte.2_Silent_p.L567L	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	570					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						GGTGCAGTCTGAGAACCTGAG	0.403													0	0	0	0.013726	0	33	35										C	95918479	G	C	95918479	2	2	13	1	0	0	0	0	0	0	0	1	17072	1277	45	1		1	USP44	12	95918479	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	9719120	95918479	37933416	211	3401										
BTBD11	121551	broad.mit.edu	37	chr12	108008937	108008937	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atggacatattcctgtagttCaggtattaacgtatttccct	7	8	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:108008937C>T	uc001tmk.1	+	7	2520	c.1999C>T	c.(1999-2001)CAG>TAG	p.Q667*	BTBD11_uc009zut.1_Nonsense_Mutation_p.Q667*|BTBD11_uc001tmj.2_Nonsense_Mutation_p.Q667*|BTBD11_uc001tml.1_Nonsense_Mutation_p.Q204*	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	667	ANK 2.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						TCCTGTAGTTCAGGTATTAAC	0.438													0	0	0	0.00308	0	8	33										T	108008937	C	T	108008937	4	4	13	1	0	0	0	0	0	1	0	0	1539	827	29	1	2130	1	BTBD11	12	108008937	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	12090458	108008937	25842958	212	3402										
SDS	10993	broad.mit.edu	37	chr12	113830871	113830871	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cggggttcggagattcccctCcagttggagcttctggatca	13	11	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr12:113830871C>T	uc001tvg.2	-	8	984	c.862G>A	c.(862-864)GAG>AAG	p.E288K		NM_006843	NP_006834	P20132	SDHL_HUMAN	serine dehydratase	288					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			pancreas(1)	1					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AGATTCCCCTCCAGTTGGAGC	0.652													0	0	0	0.01441	0	57	92										T	113830871	C	T	113830871	3	4	13	1	0	0	0	0	1	0	0	0	13975	864	30	1	128	1	SDS	12	113830871	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5821934	113830871	20021024	213	3403										
PARP4	143	broad.mit.edu	37	chr13	25074482	25074482	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttccacagtgtcttcctcctCtgtggcactgtccgggcata	9	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:25074482C>T	uc001upl.2	-	4	479	c.373G>A	c.(373-375)GAG>AAG	p.E125K	PARP4_uc010tdc.1_Missense_Mutation_p.E125K	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	125					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		TCTTCCTCCTCTGTGGCACTG	0.398													0	0	0	0.007291	0	26	55										T	25074482	C	T	25074482	3	4	13	1	0	0	0	0	1	0	0	0	11463	922	32	1	4925	1	PARP4	13	25074482	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		25074482	90095396	214	3404										
N4BP2L2	10443	broad.mit.edu	37	chr13	33110210	33110210	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gttaacatgacaattatttaCataatatccattttgtatct	3	6	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:33110210C>A	uc001uuk.3	-	2	1133	c.955G>T	c.(955-957)GTA>TTA	p.V319L	N4BP2L2_uc010abe.1_Intron|N4BP2L2_uc010tdz.1_Intron|N4BP2L2_uc001uul.1_Missense_Mutation_p.V319L|N4BP2L2_uc001uum.2_5'Flank	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	319											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		CAATTATTTACATAATATCCA	0.348													1	0	2.27731e-05	0.012319	2.37552e-05	22	49										A	33110210	C	A	33110210	3	1	13	1	0	0	0	0	1	0	0	0	10112	478	17	4	2677	4	N4BP2L2	13	33110210	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	8035728	33110210	82059668	215	3405										
FAM48A	55578	broad.mit.edu	37	chr13	37618294	37618294	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caagcaactctccttcttcaTagggcagtcgaatggtctcg	9	12	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:37618294T>C	uc001uwg.2	-	7	565	c.317A>G	c.(316-318)TAT>TGT	p.Y106C	FAM48A_uc010abt.2_Missense_Mutation_p.Y107C|FAM48A_uc001uwh.2_Missense_Mutation_p.Y107C|FAM48A_uc001uwi.2_Missense_Mutation_p.Y106C|FAM48A_uc001uwj.2_Missense_Mutation_p.Y107C|FAM48A_uc001uwk.2_Missense_Mutation_p.Y106C|FAM48A_uc010tes.1_Missense_Mutation_p.Y94C|FAM48A_uc001uwl.1_Missense_Mutation_p.Y106C	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	106					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		TCCTTCTTCATAGGGCAGTCG	0.338													0	0	0	0.007291	0	26	27										C	37618294	T	C	37618294	3	2	13	1	0	0	0	0	1	0	0	0	5572	1406	49	5	2102	5	FAM48A	13	37618294	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	4508084	37618294	77551584	216	3406										
FNDC3A	22862	broad.mit.edu	37	chr13	49752710	49752710	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttttccttttccagggatatGgttttaagcctaaatatgat	7	6	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:49752710G>A	uc001vcm.2	+	14	1842	c.1537G>A	c.(1537-1539)GGT>AGT	p.G513S	FNDC3A_uc001vcn.2_Missense_Mutation_p.G513S|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.G439S|FNDC3A_uc001vcq.2_Missense_Mutation_p.G457S	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	513	Fibronectin type-III 3.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CCAGGGATATGGTTTTAAGCC	0.338													0	0	0	0.006214	0	9	24										A	49752710	G	A	49752710	3	1	13	1	0	0	0	0	1	0	0	0	5969	1348	47	2	1598	2	FNDC3A	13	49752710	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12134416	49752710	65417168	217	3407										
ABCC4	10257	broad.mit.edu	37	chr13	95726579	95726579	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caaaaacaagaaccaagcctCtgaatttgagaacggtaata	7	8	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:95726579C>T	uc001vmd.3	-	23	2926	c.2807_splice	c.e23-1	p.E936_splice	ABCC4_uc010afk.2_Splice_Site_p.E889_splice	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4						platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	AACCAAGCCTCTGAATTTGAG	0.458													0	0	0	0.001984	0	7	15										T	95726579	C	T	95726579	5	4	13	1	0	0	0	0	0	0	1	0	55	927	32	1	1207	1	ABCC4	13	95726579	Splice_Site	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	45973869	95726579	19443299	218	3408										
DNAJC3	5611	broad.mit.edu	37	chr13	96361561	96361561	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttgcagctggacagctagctGatgctttatctcagtttcat	9	9	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:96361561G>A	uc001vmq.2	+	2	271	c.163G>A	c.(163-165)GAT>AAT	p.D55N	DNAJC3_uc001vmp.2_Missense_Mutation_p.D55N|DNAJC3_uc001vmr.2_Missense_Mutation_p.D55N	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	55	TPR 1.				protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			ACAGCTAGCTGATGCTTTATC	0.358													0	0	0	0.008291	0	10	47										A	96361561	G	A	96361561	3	1	13	1	0	0	0	0	1	0	0	0	4647	1290	45	1	169	1	DNAJC3	13	96361561	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	634982	96361561	18808317	219	3409										
LIG4	3981	broad.mit.edu	37	chr13	108861189	108861189	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtggcgtcgaaacatactgaGaggagagcaatcccaggaat	13	8	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:108861189G>C	uc001vqn.2	-	2	2701	c.2428C>G	c.(2428-2430)CTC>GTC	p.L810V	LIG4_uc001vqo.2_Missense_Mutation_p.L810V|LIG4_uc010agg.1_Missense_Mutation_p.L743V|LIG4_uc010agf.2_Missense_Mutation_p.L810V|LIG4_uc001vqp.2_Missense_Mutation_p.L810V	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	810	BRCT 2.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					AACATACTGAGAGGAGAGCAA	0.403								NHEJ					0	0	0	0.008871	0	21	43										C	108861189	G	C	108861189	3	2	13	1	0	0	0	0	1	0	0	0	8783	942	33	1	311	1	LIG4	13	108861189	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	12499628	108861189	6308689	220	3410										
MCF2L	23263	broad.mit.edu	37	chr13	113730363	113730363	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcccaggacggcgcggaggcTgccctccaggaaatcgagaa	14	13	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:113730363T>A	uc001vsu.2	+	12	1585	c.1563T>A	c.(1561-1563)GCT>GCA	p.A521A	MCF2L_uc001vsq.2_Silent_p.A521A|MCF2L_uc010tjr.1_Silent_p.A464A|MCF2L_uc001vsr.2_Silent_p.A468A|MCF2L_uc001vss.3_Silent_p.A462A|MCF2L_uc010tjs.1_Silent_p.A462A|MCF2L_uc001vst.1_Silent_p.A426A	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	494					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				GCGCGGAGGCTGCCCTCCAGG	0.522													0	0	0	0.010729	0	12	15										A	113730363	T	A	113730363	2	1	13	1	0	0	0	0	0	0	0	1	9379	1567	55	5		5	MCF2L	13	113730363	Silent	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	4869174	113730363	1439515	221	3411										
CDC16	8881	broad.mit.edu	37	chr13	115008757	115008757	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaacttcttgaatcactaccCcttagcaagctgtgtaatga	7	10	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr13:115008757C>T	uc001vuk.1	+	7	765	c.567C>T	c.(565-567)CCC>CCT	p.P189P	CDC16_uc010tkm.1_3'UTR|CDC16_uc001vul.1_Silent_p.P189P|CDC16_uc001vum.1_Silent_p.P95P|CDC16_uc001vun.1_Silent_p.P188P|CDC16_uc001vuo.1_Silent_p.P188P	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6	189					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			AATCACTACCCCTTAGCAAGC	0.308													0	0	0	0.01892	0	21	58										T	115008757	C	T	115008757	2	4	13	1	0	0	0	0	0	0	0	1	3058	610	22	2		2	CDC16	13	115008757	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1278394	115008757	161121	222	3412										
RNASE9	390443	broad.mit.edu	37	chr14	21025034	21025034	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcaataaggacacgtcttttGactttttctttggtaggtgg	10	6	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:21025034G>A	uc010aho.2	-	4	354	c.195C>T	c.(193-195)GTC>GTT	p.V65V	RNASE9_uc001vxq.3_Silent_p.V70V|RNASE9_uc010ahp.2_Silent_p.V70V|RNASE9_uc010ahq.2_Silent_p.V70V|RNASE9_uc010ahr.2_Silent_p.V70V|RNASE9_uc010ahs.2_Silent_p.V65V|RNASE9_uc010aht.2_Silent_p.V65V|RNASE9_uc010ahu.2_Silent_p.V65V	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	65						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		CACGTCTTTTGACTTTTTCTT	0.363													0	0	0	0.01441	0	46	70										A	21025034	G	A	21025034	2	1	13	1	0	0	0	0	0	0	0	1	13410	1277	45	1		1	RNASE9	14	21025034	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		21025034	86324506	223	3413										
FLJ10357	55701	broad.mit.edu	37	chr14	21556227	21556227	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agcagcactcccaccctggcCagtcgagggatcttagggct	12	14	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:21556227C>T	uc001vzp.2	+	22	4517	c.4488C>T	c.(4486-4488)GCC>GCT	p.A1496A	FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Silent_p.A734A	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	1496					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		CCACCCTGGCCAGTCGAGGGA	0.567													0	0	0	0.012319	0	22	23										T	21556227	C	T	21556227	2	4	13	1	0	0	0	0	0	0	0	1	5926	581	21	2		2	FLJ10357	14	21556227	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	531193	21556227	85793313	224	3414										
AKAP6	9472	broad.mit.edu	37	chr14	32902953	32902953	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gatgacctcagagagggtccGagacctaacctattcagtcc	10	12	2	3	rs148757348		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:32902953G>A	uc001wrq.2	+	2	424	c.254G>A	c.(253-255)CGA>CAA	p.R85Q	AKAP6_uc010aml.2_Missense_Mutation_p.R82Q	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	85					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAGAGGGTCCGAGACCTAACC	0.502													0	0	0	0.007413	0	20	17										A	32902953	G	A	32902953	3	1	13	1	0	0	0	0	1	0	0	0	455	1058	37	1	256	1	AKAP6	14	32902953	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	11346726	32902953	74446587	225	3415										
CALM1	801	broad.mit.edu	37	chr14	90867659	90867659	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcgatggcaccatcacaacaAaggaacttggaactgtcatg	10	10	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:90867659A>G	uc001xyl.1	+	3	293	c.91A>G	c.(91-93)AAG>GAG	p.K31E	CALM1_uc010atq.1_Missense_Mutation_p.K32E|CALM1_uc010atr.1_RNA|CALM1_uc001xym.1_5'UTR	NM_006888	NP_008819	P62158	CALM_HUMAN	calmodulin 1 isoform 1	31	1.|EF-hand 1.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	CATCACAACAAAGGAACTTGG	0.413													0	0	0	0.01441	0	56	27										G	90867659	A	G	90867659	3	3	13	1	0	0	0	0	1	0	0	0	2584	15	1	5	101	5	CALM1	14	90867659	Missense_Mutation	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	57964706	90867659	16481881	226	3416										
KIAA1409	57578	broad.mit.edu	37	chr14	94088400	94088400	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctaaagaggatttagatctGatagatctatcctcagattc	7	8	3	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:94088400G>A	uc001ybv.1	+	28	4439	c.4356G>A	c.(4354-4356)CTG>CTA	p.L1452L	KIAA1409_uc001ybs.1_Silent_p.L1430L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1607						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATTTAGATCTGATAGATCTAT	0.473													0	0	0	0.013537	0	13	35										A	94088400	G	A	94088400	2	1	13	1	0	0	0	0	0	0	0	1	8230	1277	45	1		1	KIAA1409	14	94088400	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3220741	94088400	13261140	227	3417										
TCL1B	9623	broad.mit.edu	37	chr14	96152883	96152883	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggcctggcatctacgaagatGaggaggggagaacctgggtg	18	7	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:96152883G>A	uc001yez.2	+	1	121	c.79G>A	c.(79-81)GAG>AAG	p.E27K	TCL1B_uc001yew.2_Intron|TCL1B_uc001yex.2_Intron|TCL1B_uc010avj.2_Intron|TCL1B_uc001yfa.2_Missense_Mutation_p.E27K	NM_004918	NP_004909	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	27										ovary(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		CTACGAAGATGAGGAGGGGAG	0.642													0	0	0	0.012319	0	22	25										A	96152883	G	A	96152883	3	1	13	1	0	0	0	0	1	0	0	0	15702	1291	45	1	81	1	TCL1B	14	96152883	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2064483	96152883	11196657	228	3418										
PACS2	23241	broad.mit.edu	37	chr14	105859633	105859633	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcattgagggcatcagccggCtcatctgcactgccaggcag	13	13	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr14:105859633C>G	uc001yqt.2	+	23	2687	c.2512C>G	c.(2512-2514)CTC>GTC	p.L838V	PACS2_uc001yqs.2_Missense_Mutation_p.L763V|PACS2_uc001yqv.2_Missense_Mutation_p.L842V|PACS2_uc001yqu.2_Missense_Mutation_p.L853V	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	838					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		CATCAGCCGGCTCATCTGCAC	0.602													0	0	0	0.00499	0	16	23										G	105859633	C	G	105859633	3	3	13	1	0	0	0	0	1	0	0	0	11373	797	28	4	2614	4	PACS2	14	105859633	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	9706750	105859633	1489907	229	3419										
OTUD7A	161725	broad.mit.edu	37	chr15	31862286	31862286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgtgcccgggctgtggctctCgctctggctgcttgggaccc	15	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr15:31862286C>T	uc001zfq.2	-	2	359	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	OTUD7A_uc001zfr.2_Missense_Mutation_p.R89Q|OTUD7A_uc001zfs.1_RNA|OTUD7A_uc010baa.1_Missense_Mutation_p.R89Q	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	89						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CTGTGGCTCTCGCTCTGGCTG	0.642													0	0	0	0.004672	0	3	44										T	31862286	C	T	31862286	3	4	13	1	0	0	0	0	1	0	0	0	11318	884	31	1	2554	1	OTUD7A	15	31862286	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		31862286	70669106	230	3420										
TGM5	9333	broad.mit.edu	37	chr15	43552715	43552715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caggtggtccacagtgatctCctccgtgtggtgccgcacat	12	13	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr15:43552715C>T	uc001zrd.1	-	2	81	c.73G>A	c.(73-75)GAG>AAG	p.E25K	TGM5_uc001zre.1_Missense_Mutation_p.E25K	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	25					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	ACAGTGATCTCCTCCGTGTGG	0.582													0	0	0	0.009718	0	41	77										T	43552715	C	T	43552715	3	4	13	1	0	0	0	0	1	0	0	0	15830	864	30	1	2137	1	TGM5	15	43552715	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	11690429	43552715	58978677	231	3421										
PARP6	56965	broad.mit.edu	37	chr15	72552924	72552924	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acttccactttggggttcttCatggtacaggagatggaacg	12	8	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr15:72552924C>T	uc002auc.2	-	9	1110	c.651G>A	c.(649-651)ATG>ATA	p.M217I	PARP6_uc002aua.2_Missense_Mutation_p.M82I|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Missense_Mutation_p.M217I	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	217							NAD+ ADP-ribosyltransferase activity				0						TGGGGTTCTTCATGGTACAGG	0.587													0	0	0	0.01441	0	202	349										T	72552924	C	T	72552924	3	4	13	1	0	0	0	0	1	0	0	0	11464	826	29	1	1301	1	PARP6	15	72552924	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	29000209	72552924	29978468	232	3422										
CCDC33	80125	broad.mit.edu	37	chr15	74588272	74588272	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aggaggaacctctggtgcctGagatgtcccatgacacagtg	13	10	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr15:74588272G>A	uc002axo.2	+	11	1667	c.1273G>A	c.(1273-1275)GAG>AAG	p.E425K	CCDC33_uc002axp.2_Missense_Mutation_p.E247K	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	628							protein binding			ovary(3)|skin(2)	5						TCTGGTGCCTGAGATGTCCCA	0.587													0	0	0	0.001984	0	7	12										A	74588272	G	A	74588272	3	1	13	1	0	0	0	0	1	0	0	0	2806	1291	45	1	1315	1	CCDC33	15	74588272	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2035348	74588272	27943120	233	3423										
SH3GL3	6457	broad.mit.edu	37	chr15	84233946	84233946	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caaaaaccactgaatatcttCagccaaatccaggtaaagtt	5	10	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr15:84233946C>A	uc002bjw.2	+	3	370	c.175C>A	c.(175-177)CAG>AAG	p.Q59K	SH3GL3_uc010bms.2_Missense_Mutation_p.Q59K|SH3GL3_uc010uot.1_Missense_Mutation_p.Q59K|SH3GL3_uc002bjx.2_5'UTR|SH3GL3_uc002bju.2_Missense_Mutation_p.Q67K|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	59	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						TGAATATCTTCAGCCAAATCC	0.294													1	0	1.99824e-07	0.00499	2.11868e-07	16	34										A	84233946	C	A	84233946	3	1	13	1	0	0	0	0	1	0	0	0	14252	827	29	3	185	3	SH3GL3	15	84233946	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	9645674	84233946	18297446	234	3424										
ACAN	176	broad.mit.edu	37	chr15	89379446	89379446	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tccaggtgaactatgaccacTttactctgggttttcgtgac	9	10	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr15:89379446T>A	uc010upo.1	+	2	383	c.9T>A	c.(7-9)ACT>ACA	p.T3T	ACAN_uc002bmx.2_Silent_p.T3T|ACAN_uc010upp.1_Silent_p.T3T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	3					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTATGACCACTTTACTCTGGG	0.468													0	0	0	0.009096	0	4	14										A	89379446	T	A	89379446	2	1	13	1	0	0	0	0	0	0	0	1	117	1596	56	5		5	ACAN	15	89379446	Silent	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	5145500	89379446	13151946	235	3425										
RHBDL1	9028	broad.mit.edu	37	chr16	726483	726483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agggccaggtctgctaccagGagctggtggacctggtcagt	16	10	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:726483G>A	uc002cis.1	+	1	409	c.382G>A	c.(382-384)GAG>AAG	p.E128K	RHBDL1_uc002cir.1_Missense_Mutation_p.E63K|RHBDL1_uc010uun.1_Missense_Mutation_p.E63K	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	128					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				CTGCTACCAGGAGCTGGTGGA	0.706													0	0	0	0.013537	0	9	9										A	726483	G	A	726483	3	1	13	1	0	0	0	0	1	0	0	0	13321	1175	41	1	384	1	RHBDL1	16	726483	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		726483	89628270	236	3426										
RHBDL1	9028	broad.mit.edu	37	chr16	726497	726497	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	taccaggagctggtggacctGgtcagtgccacggtgggcag	17	10	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:726497G>A	uc002cis.1	+	1	423	c.396G>A	c.(394-396)CTG>CTA	p.L132L	RHBDL1_uc002cir.1_Silent_p.L67L|RHBDL1_uc010uun.1_Silent_p.L67L	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	132					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				TGGTGGACCTGGTCAGTGCCA	0.706													0	0	0	0.020292	0	14	7										A	726497	G	A	726497	2	1	13	1	0	0	0	0	0	0	0	1	13321	1362	47	2		2	RHBDL1	16	726497	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	14	726497	89628256	237	3427										
BAIAP3	8938	broad.mit.edu	37	chr16	1398294	1398294	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctgcacctgtgccggcccaGagcccagggtgagtgagcat	14	14	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:1398294G>C	uc002clk.1	+	33	3452	c.3452G>C	c.(3451-3453)AGA>ACA	p.R1151T	BAIAP3_uc002clj.2_Missense_Mutation_p.R1133T|BAIAP3_uc010uuz.1_Missense_Mutation_p.R1116T|BAIAP3_uc010uva.1_Missense_Mutation_p.R1088T|BAIAP3_uc010uvc.1_Missense_Mutation_p.R1080T	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	1151					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				TGCCGGCCCAGAGCCCAGGGT	0.731													0	0	0	0.004672	0	2	12										C	1398294	G	C	1398294	3	2	13	1	0	0	0	0	1	0	0	0	1304	942	33	1	3582	1	BAIAP3	16	1398294	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	671797	1398294	88956459	238	3428										
CREBBP	1387	broad.mit.edu	37	chr16	3820792	3820792	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cgacacaggagttgatggctGagtgggagctgctggctggg	19	7	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:3820792G>A	uc002cvv.2	-	14	2863	c.2659C>T	c.(2659-2661)CAG>TAG	p.Q887*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.Q849*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	887					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTTGATGGCTGAGTGGGAGCT	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.025465	0	40	14										A	3820792	G	A	3820792	4	1	13	1	0	0	0	0	0	1	0	0	3861	1299	45	1	4741	1	CREBBP	16	3820792	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2422498	3820792	86533961	239	3429										
CREBBP	1387	broad.mit.edu	37	chr16	3820952	3820952	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcctgaggccccagcatgttGagagggttaggaagagcagc	16	9	0	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:3820952G>C	uc002cvv.2	-	14	2703	c.2499C>G	c.(2497-2499)CTC>CTG	p.L833L	CREBBP_uc002cvw.2_Silent_p.L795L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	833					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCAGCATGTTGAGAGGGTTAG	0.542			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.01441	0	58	27										C	3820952	G	C	3820952	2	2	13	1	0	0	0	0	0	0	0	1	3861	1277	45	1		1	CREBBP	16	3820952	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	160	3820952	86533801	240	3430										
GLYR1	84656	broad.mit.edu	37	chr16	4862198	4862198	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cccgtcattagacagctgctGattccctgagacgggggctt	12	12	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:4862198G>A	uc002cxx.3	-	13	1208	c.1171C>T	c.(1171-1173)CAG>TAG	p.Q391*	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Nonsense_Mutation_p.Q305*|GLYR1_uc002cya.2_Nonsense_Mutation_p.Q385*|GLYR1_uc010uxv.1_Nonsense_Mutation_p.Q310*	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	391					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						GACAGCTGCTGATTCCCTGAG	0.587													0	0	0	0.009096	0	4	24										A	4862198	G	A	4862198	4	1	13	1	0	0	0	0	0	1	0	0	6483	1299	45	1	506	1	GLYR1	16	4862198	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1041246	4862198	85492555	241	3431										
MKL2	57496	broad.mit.edu	37	chr16	14340888	14340888	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgaagaggaaactggaacaaGagcagaagctcgtggaagtg	15	5	0	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:14340888G>C	uc010uza.1	+	12	1926	c.1771G>C	c.(1771-1773)GAG>CAG	p.E591Q	MKL2_uc002dcg.2_Missense_Mutation_p.E591Q|MKL2_uc002dcj.2_5'Flank	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	580	Required for interaction with itself and with MKL1.|Potential.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						ACTGGAACAAGAGCAGAAGCT	0.532													0	0	0	0.00308	0	7	38										C	14340888	G	C	14340888	3	2	13	1	0	0	0	0	1	0	0	0	9602	943	33	1	1809	1	MKL2	16	14340888	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	9478690	14340888	76013865	242	3432										
PALB2	79728	broad.mit.edu	37	chr16	23646501	23646501	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcactttggtcagtttcctCattggaaaggtttaaatttt	7	6	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:23646501C>G	uc002dlx.1	-	4	1566	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	456					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		TCAGTTTCCTCATTGGAAAGG	0.378			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.013726	0	33	86										G	23646501	C	G	23646501	3	3	13	1	0	0	0	0	1	0	0	0	11406	835	29	1	2234	1	PALB2	16	23646501	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	9305613	23646501	66708252	243	3433										
ATP2A1	487	broad.mit.edu	37	chr16	28893844	28893844	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tggggaaggtctaccgggctGaccgcaagtcagtgcaaagg	16	9	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:28893844G>A	uc002dro.1	+	5	581	c.397G>A	c.(397-399)GAC>AAC	p.D133N	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.D133N|ATP2A1_uc002drp.1_Missense_Mutation_p.D8N	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	133	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTACCGGGCTGACCGCAAGTC	0.627													0	0	0	0.020292	0	14	44										A	28893844	G	A	28893844	3	1	13	1	0	0	0	0	1	0	0	0	1136	1290	45	1	415	1	ATP2A1	16	28893844	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	5247343	28893844	61460909	244	3434										
CD19	930	broad.mit.edu	37	chr16	28950083	28950083	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gccagcctggacccaatcatGaggaaggtgggtgcttctgc	14	11	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:28950083G>A	uc002drs.2	+	13	1635	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.E526K	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	525	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						ACCCAATCATGAGGAAGGTGG	0.622													0	0	0	0.014323	0	21	31										A	28950083	G	A	28950083	3	1	13	1	0	0	0	0	1	0	0	0	2973	1291	45	1	1626	1	CD19	16	28950083	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	56239	28950083	61404670	245	3435										
PPP4C	5531	broad.mit.edu	37	chr16	30092610	30092610	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtagaggagagcaacgtgcaGagggtggactcgccagtcac	16	9	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:30092610G>A	uc002dwe.2	+	3	273	c.129G>A	c.(127-129)CAG>CAA	p.Q43Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Silent_p.Q43Q|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_Intron	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	43					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						GCAACGTGCAGAGGGTGGACT	0.567													0	0	0	0.001984	0	7	110										A	30092610	G	A	30092610	2	1	13	1	0	0	0	0	0	0	0	1	12402	933	33	1		1	PPP4C	16	30092610	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1142527	30092610	60262143	246	3436										
ITFG1	81533	broad.mit.edu	37	chr16	47347638	47347638	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cattaaaaacaacttgatatAcctgcttcatcccagatctc	3	12	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:47347638A>G	uc002eet.2	-	9	959	c.897_splice	c.e9+1	p.Q299_splice	ITFG1_uc010vgg.1_Splice_Site_p.Q44_splice|ITFG1_uc010vgh.1_Splice_Site_p.Q186_splice	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				AACTTGATATACCTGCTTCAT	0.363													0	0	0	0.008871	0	18	31										G	47347638	A	G	47347638	5	3	13	1	0	0	0	0	0	0	1	0	7869	405	14	5	979	5	ITFG1	16	47347638	Splice_Site	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	17255028	47347638	43007115	247	3437										
RBL2	5934	broad.mit.edu	37	chr16	53504333	53504333	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gagggataacattcttccctGtccaagtcaatgttgggggg	13	8	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:53504333G>C	uc002ehi.3	+	16	2402	c.2284G>C	c.(2284-2286)GTC>CTC	p.V762L	RBL2_uc002ehj.2_Missense_Mutation_p.V472L|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	762	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ATTCTTCCCTGTCCAAGTCAA	0.502													0	0	0	0.010729	0	12	36										C	53504333	G	C	53504333	3	2	13	1	0	0	0	0	1	0	0	0	13110	1377	48	4	2346	4	RBL2	16	53504333	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	6156695	53504333	36850420	248	3438										
FTO	79068	broad.mit.edu	37	chr16	53878094	53878094	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agaggaaagtgaggatgactCtcatctcgaaggcagggatc	14	7	2	3	rs76762929	by1000genomes	TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:53878094C>T	uc002ehr.2	+	4	1001	c.779C>T	c.(778-780)TCT>TTT	p.S260F	FTO_uc010vha.1_5'UTR	NM_001080432	NP_001073901	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	260	Fe2OG dioxygenase domain.				DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GAGGATGACTCTCATCTCGAA	0.403													0	0	0	0.012319	0	21	34										T	53878094	C	T	53878094	3	4	13	1	0	0	0	0	1	0	0	0	6086	913	32	1	793	1	FTO	16	53878094	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	373761	53878094	36476659	249	3439										
IRX3	79191	broad.mit.edu	37	chr16	54319259	54319259	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aggcgccggcgcgcgttggcGaaccaggtggacacctgggt	18	12	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:54319259G>A	uc002eht.1	-	2	950	c.534C>T	c.(532-534)TTC>TTT	p.F178F		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	178	Homeobox; TALE-type.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCGCGTTGGCGAACCAGGTGG	0.607													0	0	0	0.00632	0	24	52										A	54319259	G	A	54319259	2	1	13	1	0	0	0	0	0	0	0	1	7845	1049	37	1		1	IRX3	16	54319259	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	441165	54319259	36035494	250	3440										
AP1G1	164	broad.mit.edu	37	chr16	71805129	71805129	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ataagttcaggaactttcctGatgacatgaacagcacacag	8	9	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:71805129G>A	uc010cgg.2	-	5	809	c.495C>T	c.(493-495)ATC>ATT	p.I165I	AP1G1_uc002fba.2_Silent_p.I165I|AP1G1_uc002fbb.2_Silent_p.I188I|AP1G1_uc010vmg.1_RNA|AP1G1_uc010vmh.1_Silent_p.I247I	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	165					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				GAACTTTCCTGATGACATGAA	0.318													0	0	0	0.00499	0	15	18										A	71805129	G	A	71805129	2	1	13	1	0	0	0	0	0	0	0	1	732	1280	45	1		1	AP1G1	16	71805129	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	17485870	71805129	18549624	251	3441										
PMFBP1	83449	broad.mit.edu	37	chr16	72159145	72159145	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcagctcctcacctccagctCactctcctggtggaagcccc	8	19	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:72159145C>T	uc002fcc.3	-	16	2600	c.2428G>A	c.(2428-2430)GAG>AAG	p.E810K	PMFBP1_uc002fcd.2_Missense_Mutation_p.E805K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.E660K|PMFBP1_uc010cgo.1_Missense_Mutation_p.E101K	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	810	Potential.									ovary(2)	2		Ovarian(137;0.179)				ACCTCCAGCTCACTCTCCTGG	0.498											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.025465	0	40	106										T	72159145	C	T	72159145	3	4	13	1	0	0	0	0	1	0	0	0	12134	835	29	1	694	1	PMFBP1	16	72159145	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	354016	72159145	18195608	252	3442										
NECAB2	54550	broad.mit.edu	37	chr16	84028251	84028251	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaagagggtctggaagcccaGatcagccgcttggcagagct	15	10	2	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:84028251G>C	uc002fhd.2	+	8	770	c.753G>C	c.(751-753)CAG>CAC	p.Q251H	NECAB2_uc002fhe.2_Missense_Mutation_p.Q168H	NM_019065	NP_061938	Q7Z6G3	NECA2_HUMAN	neuronal calcium-binding protein 2	251					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding			ovary(2)	2						TGGAAGCCCAGATCAGCCGCT	0.602													0	0	0	0.021553	0	5	31										C	84028251	G	C	84028251	3	2	13	1	0	0	0	0	1	0	0	0	10305	933	33	1	783	1	NECAB2	16	84028251	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	11869106	84028251	6326502	253	3443										
LRRC50	123872	broad.mit.edu	37	chr16	84182710	84182710	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgggtcaggtggtcacttcGcacacccaagagaagacagg	13	10	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr16:84182710G>A	uc002fhl.3	+	2	404	c.223G>A	c.(223-225)GCA>ACA	p.A75T	LRRC50_uc010chi.1_RNA	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	75			Missing (in CILD13).		axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						TGGTCACTTCGCACACCCAAG	0.413									Kartagener_syndrome				0	0	0	0.010818	0	33	48										A	84182710	G	A	84182710	3	1	13	1	0	0	0	0	1	0	0	0	9009	1087	38	2	229	2	LRRC50	16	84182710	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	154459	84182710	6172043	254	3444										
TRPV3	162514	broad.mit.edu	37	chr17	3433367	3433367	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttccagcactgagttgtccGtggtggtgtccacgttggtg	14	9	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:3433367G>A	uc002fvt.1	-	9	1518	c.1196C>T	c.(1195-1197)ACG>ATG	p.T399M	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.T383M|TRPV3_uc010vri.1_Missense_Mutation_p.T354M|TRPV3_uc010vrj.1_Missense_Mutation_p.T383M|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.T383M|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.T399M|TRPV3_uc002fvu.2_Missense_Mutation_p.T399M|TRPV3_uc010vrn.1_Translation_Start_Site	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	399	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	TGAGTTGTCCGTGGTGGTGTC	0.607													0	0	0	0.015359	0	30	18										A	3433367	G	A	3433367	3	1	13	1	0	0	0	0	1	0	0	0	16594	1145	40	2	1216	2	TRPV3	17	3433367	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		3433367	77761843	255	3445										
GPS2	2874	broad.mit.edu	37	chr17	7217458	7217458	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggctctgctggtatgcagctGatgttagggtggtcaggtca	16	7	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:7217458G>T	uc002gfv.1	-	4	601	c.338C>A	c.(337-339)TCA>TAA	p.S113*	GPS2_uc002gfw.1_Nonsense_Mutation_p.S75*|GPS2_uc002gfx.1_Nonsense_Mutation_p.S113*|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Nonsense_Mutation_p.S113*	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	113					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				GTATGCAGCTGATGTTAGGGT	0.488													1	0	1.93748e-29	0.01441	2.1423e-29	54	36										T	7217458	G	T	7217458	4	4	13	1	0	0	0	0	0	1	0	0	6733	1294	45	3	673	3	GPS2	17	7217458	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3784091	7217458	73977752	256	3446										
MYH13	8735	broad.mit.edu	37	chr17	10219314	10219314	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttcactaaattgatcttctAccgtccggcacgttctttct	5	12	5	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:10219314A>G	uc002gmk.1	-	28	3857	c.3767T>C	c.(3766-3768)GTA>GCA	p.V1256A		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1256	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TTGATCTTCTACCGTCCGGCA	0.428													0	0	0	0.028581	0	17	39										G	10219314	A	G	10219314	3	3	13	1	0	0	0	0	1	0	0	0	10032	391	14	5	2105	5	MYH13	17	10219314	Missense_Mutation	SNP	A	TCGA-BT-A20T-01A-11D-A14W-08	3001856	10219314	70975896	257	3447										
MYO18A	399687	broad.mit.edu	37	chr17	27437053	27437053	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gggctccccagcccagccctCagctacaggcaggaagcagt	12	16	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:27437053C>T	uc002hdt.1	-	19	3312	c.3154G>A	c.(3154-3156)GAG>AAG	p.E1052K	MYO18A_uc010wbc.1_Missense_Mutation_p.E594K|MYO18A_uc002hds.2_Missense_Mutation_p.E594K|MYO18A_uc010csa.1_Missense_Mutation_p.E1052K|MYO18A_uc002hdu.1_Missense_Mutation_p.E1052K|MYO18A_uc010wbd.1_Missense_Mutation_p.E721K	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1052	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GCCCAGCCCTCAGCTACAGGC	0.647													0	0	0	0.004482	0	8	24										T	27437053	C	T	27437053	3	4	13	1	0	0	0	0	1	0	0	0	10065	835	29	1	3106	1	MYO18A	17	27437053	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	17217739	27437053	53758157	258	3448										
ACCN1	40	broad.mit.edu	37	chr17	31344625	31344625	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gggaatcccaaatcttacctCataaatataatcaaagagct	5	9	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:31344625C>G	uc002hhu.2	-	8	1640	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q	ACCN1_uc002hht.2_Missense_Mutation_p.E507Q	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	456	Cytoplasmic (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding	p.L456fs*2(1)		ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	AATCTTACCTCATAAATATAA	0.473													0	0	0	0.020292	0	13	24										G	31344625	C	G	31344625	3	3	13	1	0	0	0	0	1	0	0	0	128	835	29	1	184	1	ACCN1	17	31344625	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3907572	31344625	49850585	259	3449										
ERBB2	2064	broad.mit.edu	37	chr17	37872839	37872839	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtgtcagccccagaatggctCagtgacctgttttggaccgg	13	11	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:37872839C>T	uc002hso.2	+	14	1956	c.1718C>T	c.(1717-1719)TCA>TTA	p.S573L	ERBB2_uc002hsm.2_Missense_Mutation_p.S543L|ERBB2_uc010cwa.2_Missense_Mutation_p.S558L|ERBB2_uc002hsp.2_Missense_Mutation_p.S376L|ERBB2_uc010cwb.2_Missense_Mutation_p.S573L|ERBB2_uc010wek.1_Missense_Mutation_p.S297L|ERBB2_uc002hsl.2_Missense_Mutation_p.S543L	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	573	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CAGAATGGCTCAGTGACCTGT	0.637		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.010729	0	10	19										T	37872839	C	T	37872839	3	4	13	1	0	0	0	0	1	0	0	0	5206	838	29	1	1772	1	ERBB2	17	37872839	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	6528214	37872839	43322371	260	3450										
NBR1	4077	broad.mit.edu	37	chr17	41355748	41355748	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	actggtgaagggggctttgtCtgttgctgcctctgcataca	13	9	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:41355748C>T	uc010czd.2	+	20	2812	c.2672C>T	c.(2671-2673)TCT>TTT	p.S891F	NBR1_uc010diz.2_Missense_Mutation_p.S891F|NBR1_uc010whu.1_Missense_Mutation_p.S891F|NBR1_uc010whv.1_Missense_Mutation_p.S891F|NBR1_uc010whw.1_Intron	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	891					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GGGGCTTTGTCTGTTGCTGCC	0.493													0	0	0	0.004482	0	7	11										T	41355748	C	T	41355748	3	4	13	1	0	0	0	0	1	0	0	0	10200	913	32	1	2746	1	NBR1	17	41355748	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3482909	41355748	39839462	261	3451										
NBR1	4077	broad.mit.edu	37	chr17	41355760	41355760	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggctttgtctgttgctgcctCtgcatacaaggccctgtttg	11	11	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:41355760C>T	uc010czd.2	+	20	2824	c.2684C>T	c.(2683-2685)TCT>TTT	p.S895F	NBR1_uc010diz.2_Missense_Mutation_p.S895F|NBR1_uc010whu.1_Missense_Mutation_p.S895F|NBR1_uc010whv.1_Missense_Mutation_p.S895F|NBR1_uc010whw.1_Intron	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	895					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GTTGCTGCCTCTGCATACAAG	0.502													0	0	0	0.001984	0	7	10										T	41355760	C	T	41355760	3	4	13	1	0	0	0	0	1	0	0	0	10200	913	32	1	2758	1	NBR1	17	41355760	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	12	41355760	39839450	262	3452										
HEXIM1	10614	broad.mit.edu	37	chr17	43227360	43227360	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gtttctgcagcgggacttctCggagacgtacgagcggtacc	14	11	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:43227360C>T	uc002iig.2	+	1	2677	c.803C>T	c.(802-804)TCG>TTG	p.S268L		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	268					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						CGGGACTTCTCGGAGACGTAC	0.602													0	0	0	0.007413	0	19	31										T	43227360	C	T	43227360	3	4	13	1	0	0	0	0	1	0	0	0	7076	893	31	1	805	1	HEXIM1	17	43227360	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1871600	43227360	37967850	263	3453										
DLX3	1747	broad.mit.edu	37	chr17	48070801	48070801	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccagctgcgcggccagctcgGcgcgctcgggcagcgccagg	17	17	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:48070801G>A	uc002ipy.2	-	2	705	c.479C>T	c.(478-480)GCC>GTC	p.A160V		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	160	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCCAGCTCGGCGCGCTCGGG	0.711													0	0	0	0.014758	0	3	14										A	48070801	G	A	48070801	3	1	13	1	0	0	0	0	1	0	0	0	4572	1203	42	2	392	2	DLX3	17	48070801	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	4843441	48070801	33124409	264	3454										
HLF	3131	broad.mit.edu	37	chr17	53345431	53345431	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccatctccgaactgtatgcaGagccccatcagaccaggtaa	8	14	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:53345431G>C	uc002iug.1	+	2	960	c.435G>C	c.(433-435)CAG>CAC	p.Q145H	HLF_uc010dce.1_Missense_Mutation_p.Q60H|HLF_uc002iuh.2_Missense_Mutation_p.Q60H|HLF_uc010wni.1_Missense_Mutation_p.R94T	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	145					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						ACTGTATGCAGAGCCCCATCA	0.582			T	TCF3	ALL								0	0	0	0.013726	0	34	61										C	53345431	G	C	53345431	3	2	13	1	0	0	0	0	1	0	0	0	7214	933	33	1	441	1	HLF	17	53345431	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	5274630	53345431	27849779	265	3455										
LRRC37A3	374819	broad.mit.edu	37	chr17	62865278	62865278	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gttgtcagaggattgtgattGagaattctgaaaaatggaat	12	2	2	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:62865278G>C	uc002jey.2	-	8	3444	c.2913C>G	c.(2911-2913)CTC>CTG	p.L971L	LRRC37A3_uc010wqg.1_Silent_p.L89L|LRRC37A3_uc010wqf.1_Silent_p.L9L|LRRC37A3_uc010dek.1_5'UTR	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	971	Extracellular (Potential).|LRR 8.					integral to membrane					0						GATTGTGATTGAGAATTCTGA	0.318													0	0	0	0.025465	0	32	104										C	62865278	G	C	62865278	2	2	13	1	0	0	0	0	0	0	0	1	8993	1277	45	1		1	LRRC37A3	17	62865278	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	9519847	62865278	18329932	266	3456										
ABCA5	23461	broad.mit.edu	37	chr17	67270112	67270112	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	actctcaccagcagaattttGaagaagcagacttgttttgt	8	8	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:67270112G>A	uc002jif.2	-	19	3970	c.2752C>T	c.(2752-2754)CAA>TAA	p.Q918*	ABCA5_uc002jic.2_Nonsense_Mutation_p.Q141*|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Nonsense_Mutation_p.Q918*|ABCA5_uc002jih.2_Nonsense_Mutation_p.Q918*|ABCA5_uc010dfe.2_Nonsense_Mutation_p.Q918*	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	918					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GCAGAATTTTGAAGAAGCAGA	0.393													0	0	0	0.015359	0	34	49										A	67270112	G	A	67270112	4	1	13	1	0	0	0	0	0	1	0	0	35	1299	45	1	2256	1	ABCA5	17	67270112	Nonsense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	4404834	67270112	13925098	267	3457										
GGA3	23163	broad.mit.edu	37	chr17	73235955	73235955	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caagccatggtgcccagggaCtgcgggctcaacttttgggg	15	11	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:73235955C>A	uc002jni.1	-	13	1507	c.1498G>T	c.(1498-1500)GTC>TTC	p.V500F	GGA3_uc002jnj.1_Missense_Mutation_p.V467F|GGA3_uc010wrw.1_Missense_Mutation_p.V378F|GGA3_uc002jnk.1_Missense_Mutation_p.V428F|GGA3_uc010wrx.1_Missense_Mutation_p.V378F|GGA3_uc010wry.1_Missense_Mutation_p.V428F	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	500	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGCCCAGGGACTGCGGGCTCA	0.617													1	0	3.07112e-06	0.010729	3.22968e-06	8	24										A	73235955	C	A	73235955	3	1	13	1	0	0	0	0	1	0	0	0	6354	565	20	4	781	4	GGA3	17	73235955	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	5965843	73235955	7959255	268	3458										
FSCN2	25794	broad.mit.edu	37	chr17	79496104	79496104	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccctcatcttccggagccgaCggtactgcctcaagtcctgt	9	16	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr17:79496104C>G	uc010wup.1	+	1	688	c.547C>G	c.(547-549)CGG>GGG	p.R183G	FSCN2_uc010wuo.1_Missense_Mutation_p.R183G	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	183					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CCGGAGCCGACGGTACTGCCT	0.682													0	0	0	0.009096	0	4	7										G	79496104	C	G	79496104	3	3	13	1	0	0	0	0	1	0	0	0	6068	527	19	4	549	4	FSCN2	17	79496104	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	6260149	79496104	1699106	269	3459										
TYMS	7298	broad.mit.edu	37	chr18	670747	670747	+	Silent	SNP	G	G	A													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctctgccagttctatgtggtGaacagtgagctgtcctgcca							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr18:670747G>A	uc010dka.1	+	5	751	c.612G>A	c.(610-612)GTG>GTA	p.V204V	TYMS_uc010dkb.1_Silent_p.V170V|TYMS_uc010dkc.1_Silent_p.V121V	NM_001071	NP_001062	P04818	TYSY_HUMAN	thymidylate synthase	204					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity				0					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	TCTATGTGGTGAACAGTGAGC	0.552													0	0	0	0.013726	0	32	45										A	670747	G	A	670747	2	1	13	1	0	0	0	0	0	0	0	1	16809	1277	45	1		1	TYMS	18	670747	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		670747	77406501	270	3460	20	2								
TYMS	7298	broad.mit.edu	37	chr18	670754	670754	+	Missense_Mutation	SNP	G	G	A													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	agttctatgtggtgaacagtGagctgtcctgccagctgtac							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr18:670754G>A	uc010dka.1	+	5	758	c.619G>A	c.(619-621)GAG>AAG	p.E207K	TYMS_uc010dkb.1_Missense_Mutation_p.E173K|TYMS_uc010dkc.1_Missense_Mutation_p.E124K	NM_001071	NP_001062	P04818	TYSY_HUMAN	thymidylate synthase	207					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity				0					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	GGTGAACAGTGAGCTGTCCTG	0.567													0	0	0	0.012213	0	30	46										A	670754	G	A	670754	3	1	13	1	0	0	0	0	1	0	0	0	16809	1291	45	1	637	1	TYMS	18	670754	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	7	670754	77406494	271	3461	20	2								
CHMP1B	57132	broad.mit.edu	37	chr18	11851604	11851604	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gcgataaggaggaaaaggccGaaaaggccaaaattaaaaag	12	5	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr18:11851604G>A	uc002kqe.2	+	1	216	c.94G>A	c.(94-96)GAA>AAA	p.E32K	GNAL_uc002kqc.2_Intron|GNAL_uc010dkz.2_Intron|GNAL_uc002kqd.2_Intron	NM_020412	NP_065145	Q7LBR1	CHM1B_HUMAN	chromatin modifying protein 1B	32	Potential.				cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding				0						GGAAAAGGCCGAAAAGGCCAA	0.473													0	0	0	0.021553	0	6	9										A	11851604	G	A	11851604	3	1	13	1	0	0	0	0	1	0	0	0	3353	1059	37	1	96	1	CHMP1B	18	11851604	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	11180850	11851604	66225644	272	3462										
RPRD1A	55197	broad.mit.edu	37	chr18	33607165	33607165	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acctgttattttatctaataGagatacttcttggacttcaa	5	7	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr18:33607165G>A	uc002kzf.1	-	5	601	c.595C>T	c.(595-597)CTA>TTA	p.L199L	RPRD1A_uc002kze.1_Silent_p.L163L|RPRD1A_uc002kzg.2_Silent_p.L199L|RPRD1A_uc010dmw.2_Silent_p.L163L|RPRD1A_uc010dmx.2_Silent_p.L199L	NM_018170	NP_060640	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing	199										ovary(1)|breast(1)	2						TTATCTAATAGAGATACTTCT	0.368													0	0	0	0.027356	0	26	60										A	33607165	G	A	33607165	2	1	13	1	0	0	0	0	0	0	0	1	13615	933	33	1		1	RPRD1A	18	33607165	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	21755561	33607165	44470083	273	3463										
MYO5B	4645	broad.mit.edu	37	chr18	47363122	47363122	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acacagggagcagatagcctCtgcgtcctcctgggttttct	11	12	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr18:47363122C>G	uc002leb.2	-	38	5560	c.5272G>C	c.(5272-5274)GAG>CAG	p.E1758Q	MYO5B_uc002ldz.2_Missense_Mutation_p.E328Q|MYO5B_uc002lea.2_Missense_Mutation_p.E873Q	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1758	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CAGATAGCCTCTGCGTCCTCC	0.532													0	0	0	0.021523	0	23	30										G	47363122	C	G	47363122	3	3	13	1	0	0	0	0	1	0	0	0	10079	922	32	1	286	1	MYO5B	18	47363122	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	13755957	47363122	30714126	274	3464										
REXO1	57455	broad.mit.edu	37	chr19	1818820	1818820	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgggtgagcaggtactccctGaggcggctgtacagggcagc	17	10	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:1818820G>A	uc002lua.3	-	9	2882	c.2787C>T	c.(2785-2787)CTC>CTT	p.L929L	REXO1_uc010dsq.2_Silent_p.L238L|REXO1_uc010xgs.1_5'UTR|MIR1909_hsa-mir-1909|MI0008330_5'Flank|REXO1_uc010dsp.1_RNA	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	929						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTACTCCCTGAGGCGGCTGT	0.677													0	0	0	0.004482	0	8	17										A	1818820	G	A	1818820	2	1	13	1	0	0	0	0	0	0	0	1	13241	1277	45	1		1	REXO1	19	1818820	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		1818820	57310163	275	3465										
TICAM1	148022	broad.mit.edu	37	chr19	4816641	4816641	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gccacctggagctgctccatCtgtgcctggtaggacaagta	12	12	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:4816641C>A	uc002mbi.2	-	2	2000	c.1749G>T	c.(1747-1749)CAG>CAT	p.Q583H		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	583	Sufficient to induce apoptosis.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCTGCTCCATCTGTGCCTGGT	0.632													1	0	3.59834e-05	0.021553	3.73339e-05	5	42										A	4816641	C	A	4816641	3	1	13	1	0	0	0	0	1	0	0	0	15889	912	32	3	393	3	TICAM1	19	4816641	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2997821	4816641	54312342	276	3466										
TICAM1	148022	broad.mit.edu	37	chr19	4816911	4816911	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctgagctgggccggggagctCtccaggggcaggaaggggat	20	9	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:4816911C>G	uc002mbi.2	-	2	1730	c.1479G>C	c.(1477-1479)GAG>GAC	p.E493D		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	493				E->A: Loss of TCAM1-induced NF-kappa-B and IRF3 activation.	apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CCGGGGAGCTCTCCAGGGGCA	0.652													0	0	0	0.001984	0	6	29										G	4816911	C	G	4816911	3	3	13	1	0	0	0	0	1	0	0	0	15889	912	32	1	663	1	TICAM1	19	4816911	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	270	4816911	54312072	277	3467										
INSR	3643	broad.mit.edu	37	chr19	7267597	7267597	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acagaaccccgggtgatgttCatcaggttgtagaggccgag	14	9	2	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:7267597C>T	uc002mgd.1	-	2	520	c.411G>A	c.(409-411)ATG>ATA	p.M137I	INSR_uc002mge.1_Missense_Mutation_p.M137I|INSR_uc002mgf.2_Missense_Mutation_p.M137I	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	137					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGGTGATGTTCATCAGGTTGT	0.522													0	0	0	0.020292	0	15	44										T	7267597	C	T	7267597	3	4	13	1	0	0	0	0	1	0	0	0	7773	826	29	1	3821	1	INSR	19	7267597	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2450686	7267597	51861386	278	3468										
MUC16	94025	broad.mit.edu	37	chr19	8999519	8999519	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cttttgggatcagggcggtaGgtgcagatggcatccacttt	14	8	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:8999519G>C	uc002mkp.2	-	56	40860	c.40656C>G	c.(40654-40656)ACC>ACG	p.T13552T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.T369T|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGCGGTAGGTGCAGATGG	0.597													0	0	0	0.027894	0	40	63										C	8999519	G	C	8999519	2	2	13	1	0	0	0	0	0	0	0	1	9973	987	35	4		4	MUC16	19	8999519	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1731922	8999519	50129464	279	3469										
QTRT1	81890	broad.mit.edu	37	chr19	10812162	10812162	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gggagcagctacccaggcttCcctggagtcggccccacgga	14	15	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:10812162C>T	uc002mpr.2	+	1	51	c.26C>T	c.(25-27)TCC>TTC	p.S9F		NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	9					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			ACCCAGGCTTCCCTGGAGTCG	0.692													0	0	0	0.004672	0	3	14										T	10812162	C	T	10812162	3	4	13	1	0	0	0	0	1	0	0	0	12885	855	30	1	28	1	QTRT1	19	10812162	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1812643	10812162	48316821	280	3470										
SMARCA4	6597	broad.mit.edu	37	chr19	11123707	11123707	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cgagatgggcctggggaagaCcatccagaccatcgcgctca	13	13	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:11123707C>A	uc002mqf.3	+	16	2641	c.2357C>A	c.(2356-2358)ACC>AAC	p.T786N	SMARCA4_uc010dxp.2_Missense_Mutation_p.T786N|SMARCA4_uc010dxo.2_Missense_Mutation_p.T786N|SMARCA4_uc002mqg.1_Missense_Mutation_p.T786N|SMARCA4_uc010dxq.2_Missense_Mutation_p.T786N|SMARCA4_uc010dxr.2_Missense_Mutation_p.T786N|SMARCA4_uc002mqj.3_Missense_Mutation_p.T786N|SMARCA4_uc010dxs.2_Missense_Mutation_p.T786N|SMARCA4_uc010dxt.1_Missense_Mutation_p.T6N	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	786	Helicase ATP-binding.|ATP (Potential).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGGGGAAGACCATCCAGACC	0.577			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				1	0	3.52763e-06	0.00499	3.69971e-06	18	26										A	11123707	C	A	11123707	3	1	13	1	0	0	0	0	1	0	0	0	14770	507	18	4	2415	4	SMARCA4	19	11123707	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	311545	11123707	48005276	281	3471										
ZNF208	7757	broad.mit.edu	37	chr19	22156562	22156562	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgccacattcttcacatttgTagggtttctctccagtatga	7	10	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:22156562T>C	uc002nqp.2	-	4	1423	c.1274A>G	c.(1273-1275)TAC>TGC	p.Y425C	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTCACATTTGTAGGGTTTCTC	0.388													0	0	0	0.013726	0	33	53										C	22156562	T	C	22156562	3	2	13	1	0	0	0	0	1	0	0	0	17763	1638	57	5	2572	5	ZNF208	19	22156562	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	11032855	22156562	36972421	282	3472										
ZNF146	7705	broad.mit.edu	37	chr19	36728009	36728009	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttgtggaaaagccttctctCagagctcatctctcactgtg	8	11	5	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:36728009C>T	uc002odq.3	+	4	2190	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	ZNF146_uc010eet.2_Nonsense_Mutation_p.Q223*|ZNF146_uc010eeu.2_Nonsense_Mutation_p.Q223*	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	223	Interaction with TERF2IP.|C2H2-type 8.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					AGCCTTCTCTCAGAGCTCATC	0.443													0	0	0	0.011902	0	47	75										T	36728009	C	T	36728009	4	4	13	1	0	0	0	0	0	1	0	0	17730	827	29	1	669	1	ZNF146	19	36728009	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	14571447	36728009	22400974	283	3473										
ACTN4	81	broad.mit.edu	37	chr19	39214966	39214966	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caccccgcaaatcatcaactCcaagtgggagaaggtgggcc	11	13	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:39214966C>A	uc002oja.1	+	15	1921	c.1862C>A	c.(1861-1863)TCC>TAC	p.S621Y	ACTN4_uc002ojb.1_5'Flank	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	621	Spectrin 3.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			ATCATCAACTCCAAGTGGGAG	0.667													1	0	3.07112e-06	0.010729	3.22968e-06	12	16										A	39214966	C	A	39214966	3	1	13	1	0	0	0	0	1	0	0	0	207	855	30	3	1920	3	ACTN4	19	39214966	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2486957	39214966	19914017	284	3474										
SPTBN4	57731	broad.mit.edu	37	chr19	41008156	41008156	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caatcagaaatttgccaactCcttaagtggggtgcagcagc	10	10	1	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:41008156C>T	uc002ony.2	+	9	1105	c.1019C>T	c.(1018-1020)TCC>TTC	p.S340F	SPTBN4_uc002onx.2_Missense_Mutation_p.S340F|SPTBN4_uc002onz.2_Missense_Mutation_p.S340F	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	340	Spectrin 1.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTTGCCAACTCCTTAAGTGGG	0.602													0	0	0	0.00499	0	17	59										T	41008156	C	T	41008156	3	4	13	1	0	0	0	0	1	0	0	0	15120	855	30	1	1049	1	SPTBN4	19	41008156	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1793190	41008156	18120827	285	3475										
PSG2	5670	broad.mit.edu	37	chr19	43575862	43575862	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atccacttaccagagactttGactgtcaacgatgtggagct	9	10	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:43575862G>C	uc002ovr.2	-	4	1047	c.954C>G	c.(952-954)GTC>GTG	p.V318V	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.V318V|PSG2_uc010eiq.1_Silent_p.V318V|PSG2_uc002ovs.3_Silent_p.V318V|PSG2_uc002ovt.3_Silent_p.V318V	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	318					cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				CAGAGACTTTGACTGTCAACG	0.458													0	0	0	0.01441	0	93	152										C	43575862	G	C	43575862	2	2	13	1	0	0	0	0	0	0	0	1	12655	1277	45	1		1	PSG2	19	43575862	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2567706	43575862	15553121	286	3476										
ZNF230	7773	broad.mit.edu	37	chr19	44514437	44514437	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ataggcggcaagactattgcGgaagcaggaccacatgaaga	13	8	0	3	rs150544790		TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:44514437G>A	uc002oyb.1	+	5	497	c.246G>A	c.(244-246)GCG>GCA	p.A82A		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	82	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				AGACTATTGCGGAAGCAGGAC	0.423													0	0	0	0.004672	0	3	36										A	44514437	G	A	44514437	2	1	13	1	0	0	0	0	0	0	0	1	17781	1103	39	2		2	ZNF230	19	44514437	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	938575	44514437	14614546	287	3477										
ZNF180	7733	broad.mit.edu	37	chr19	44981167	44981167	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcctgtgtgagttctctgatGagcaacaagtttataacttt	8	7	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:44981167G>A	uc002ozf.3	-	5	1813	c.1531C>T	c.(1531-1533)CAT>TAT	p.H511Y	ZNF180_uc002ozh.3_Missense_Mutation_p.H168Y|ZNF180_uc002ozi.3_Missense_Mutation_p.H484Y|ZNF180_uc002ozg.3_Missense_Mutation_p.H510Y|ZNF180_uc010ejm.2_Missense_Mutation_p.H486Y	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	511	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				GTTCTCTGATGAGCAACAAGT	0.393													0	0	0	0.00499	0	18	86										A	44981167	G	A	44981167	3	1	13	1	0	0	0	0	1	0	0	0	17745	1290	45	1	551	1	ZNF180	19	44981167	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	466730	44981167	14147816	288	3478										
PNMAL1	55228	broad.mit.edu	37	chr19	46973831	46973831	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgatctgcaccactgctccCagaagcacccccagagcttc	7	17	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:46973831C>A	uc002peq.3	-	2	768	c.462G>T	c.(460-462)CTG>CTT	p.L154L	PNMAL1_uc002per.3_Silent_p.L154L	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	154											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CCACTGCTCCCAGAAGCACCc	0.343													1	0	1.74807e-11	0.010818	1.89497e-11	30	70										A	46973831	C	A	46973831	2	1	13	1	0	0	0	0	0	0	0	1	12157	581	21	4		4	PNMAL1	19	46973831	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	1992664	46973831	12155152	289	3479										
SYT3	84258	broad.mit.edu	37	chr19	51129249	51129249	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggaggtagcagagtgagaagTtgagctccccaagatctgct	14	8	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:51129249T>C	uc002pst.2	-	5	1941	c.1307A>G	c.(1306-1308)AAC>AGC	p.N436S	SYT3_uc002psv.2_Missense_Mutation_p.N436S|SYT3_uc010ycd.1_Missense_Mutation_p.N436S	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	436	C2 2.|Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		GAGTGAGAAGTTGAGCTCCCC	0.557													0	0	0	0.001984	0	6	10										C	51129249	T	C	51129249	3	2	13	1	0	0	0	0	1	0	0	0	15472	1725	60	5	481	5	SYT3	19	51129249	Missense_Mutation	SNP	T	TCGA-BT-A20T-01A-11D-A14W-08	4155418	51129249	7999734	290	3480										
SIGLEC10	89790	broad.mit.edu	37	chr19	51914402	51914402	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cctgggtgcccttgggcatcCgggcctcaggcctgggtctg	16	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:51914402C>T	uc002pwo.2	-	11	2661	c.2045G>A	c.(2044-2046)CGG>CAG	p.R682Q	SIGLEC10_uc002pwp.2_Missense_Mutation_p.R624Q|SIGLEC10_uc002pwq.2_Missense_Mutation_p.R529Q|SIGLEC10_uc002pwr.2_Missense_Mutation_p.R587Q|SIGLEC10_uc010ycy.1_Missense_Mutation_p.R497Q|SIGLEC10_uc010ycz.1_Missense_Mutation_p.R539Q|SIGLEC10_uc010eow.2_Missense_Mutation_p.R399Q	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	682	Cytoplasmic (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CTTGGGCATCCGGGCCTCAGG	0.572													0	0	0	0.016522	0	25	77										T	51914402	C	T	51914402	3	4	13	1	0	0	0	0	1	0	0	0	14306	652	23	2	52	2	SIGLEC10	19	51914402	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	785153	51914402	7214581	291	3481										
NLRP2	55655	broad.mit.edu	37	chr19	55494635	55494635	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctggagaaggaggaggaagaGgatagggacggccacacctg	18	7	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:55494635G>A	uc002qij.2	+	6	1655	c.1569G>A	c.(1567-1569)GAG>GAA	p.E523E	NLRP2_uc010yfp.1_Silent_p.E500E|NLRP2_uc010esn.2_Silent_p.E499E|NLRP2_uc010eso.2_Silent_p.E520E|NLRP2_uc010esp.2_Silent_p.E501E	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	523	NACHT.|Poly-Glu.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGGAGGAAGAGGATAGGGACG	0.557													0	0	0	0.007413	0	19	58										A	55494635	G	A	55494635	2	1	13	1	0	0	0	0	0	0	0	1	10477	991	35	2		2	NLRP2	19	55494635	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	3580233	55494635	3634348	292	3482										
NLRP9	338321	broad.mit.edu	37	chr19	56223188	56223188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cagcatctgcagggcacagtCcgggtggctcaatgcctcac	12	14	3	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:56223188C>T	uc002qly.2	-	8	2849	c.2821G>A	c.(2821-2823)GAC>AAC	p.D941N		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	941						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AGGGCACAGTCCGGGTGGCTC	0.552													0	0	0	0.014758	0	5	25										T	56223188	C	T	56223188	3	4	13	1	0	0	0	0	1	0	0	0	10484	855	30	1	162	1	NLRP9	19	56223188	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	728553	56223188	2905795	293	3483										
NLRP4	147945	broad.mit.edu	37	chr19	56369819	56369819	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgtgtaccagtctgaagcaaGagatgcagaaaggaaaagac	12	6	1	4			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:56369819G>A	uc002qmd.3	+	3	1482	c.1060G>A	c.(1060-1062)GAG>AAG	p.E354K	NLRP4_uc002qmf.2_Missense_Mutation_p.E279K|NLRP4_uc010etf.2_Missense_Mutation_p.E185K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	354	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCTGAAGCAAGAGATGCAGAA	0.507													0	0	0	0.01892	0	25	43										A	56369819	G	A	56369819	3	1	13	1	0	0	0	0	1	0	0	0	10479	943	33	1	1066	1	NLRP4	19	56369819	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	146631	56369819	2759164	294	3484										
ZNF471	57573	broad.mit.edu	37	chr19	57027736	57027736	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aagcgtttatacaggagtatGatgttggagaactatcagag	12	4	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr19:57027736G>A	uc002qnh.2	+	3	259	c.126G>A	c.(124-126)ATG>ATA	p.M42I		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		ACAGGAGTATGATGTTGGAGA	0.393													0	0	0	0.012319	0	21	96										A	57027736	G	A	57027736	3	1	13	1	0	0	0	0	1	0	0	0	17927	1290	45	1	132	1	ZNF471	19	57027736	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	657917	57027736	2101247	295	3485										
RIN2	54453	broad.mit.edu	37	chr20	19941346	19941346	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttcttttccctccactagatCttcctggttcataaatctac	3	13	4	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr20:19941346C>G	uc002wro.1	+	4	390	c.354C>G	c.(352-354)ATC>ATG	p.I118M	RIN2_uc010gcu.1_Missense_Mutation_p.I118M|RIN2_uc010gcv.1_Translation_Start_Site	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	118	SH2.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TCCACTAGATCTTCCTGGTTC	0.438													0	0	0	0.004672	0	3	7										G	19941346	C	G	19941346	3	3	13	1	0	0	0	0	1	0	0	0	13372	903	32	1	368	1	RIN2	20	19941346	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		19941346	43084174	296	3486										
EMILIN3	90187	broad.mit.edu	37	chr20	39990777	39990777	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	caatgttgctaggcgctcctCgaggctctgcacgcgctctt	11	14	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr20:39990777C>T	uc002xjy.1	-	4	1656	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	478	Potential.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				AGGCGCTCCTCGAGGCTCTGC	0.637													0	0	0	0.020292	0	14	62										T	39990777	C	T	39990777	3	4	13	1	0	0	0	0	1	0	0	0	5095	893	31	1	872	1	EMILIN3	20	39990777	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	20049431	39990777	23034743	297	3487										
NCOA3	8202	broad.mit.edu	37	chr20	46265061	46265061	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gaccaactcccccctagattCaagttgtaaagaatcttctg	6	12	3	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr20:46265061C>G	uc002xtk.2	+	12	2136	c.1931C>G	c.(1930-1932)TCA>TGA	p.S644*	NCOA3_uc010ght.1_Nonsense_Mutation_p.S654*|NCOA3_uc002xtl.2_Nonsense_Mutation_p.S644*|NCOA3_uc002xtm.2_Nonsense_Mutation_p.S644*|NCOA3_uc002xtn.2_Nonsense_Mutation_p.S644*|NCOA3_uc010zyc.1_Nonsense_Mutation_p.S439*	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	644	Ser-rich.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CCCCTAGATTCAAGTTGTAAA	0.463													0	0	0	0.023175	0	39	63										G	46265061	C	G	46265061	4	3	13	1	0	0	0	0	0	1	0	0	10230	838	29	1	1999	1	NCOA3	20	46265061	Nonsense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	6274284	46265061	16760459	298	3488										
CSE1L	1434	broad.mit.edu	37	chr20	47691370	47691370	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ttctgaggagtacataaggaGagatttggaaggatctggtg	15	3	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr20:47691370G>C	uc002xty.2	+	11	1249	c.1115G>C	c.(1114-1116)AGA>ACA	p.R372T	CSE1L_uc010zyg.1_Missense_Mutation_p.R155T|CSE1L_uc010ghx.2_Missense_Mutation_p.R316T|CSE1L_uc010ghy.2_Missense_Mutation_p.R21T|CSE1L_uc010zyh.1_Missense_Mutation_p.R21T	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	372					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TACATAAGGAGAGATTTGGAA	0.388													0	0	0	0.00499	0	18	33										C	47691370	G	C	47691370	3	2	13	1	0	0	0	0	1	0	0	0	3930	942	33	1	1153	1	CSE1L	20	47691370	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	1426309	47691370	15334150	299	3489										
LAMA5	3911	broad.mit.edu	37	chr20	60891982	60891982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cagggcctggccagcagcatCctcggcagcctgcacggcct	13	17	0	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr20:60891982C>T	uc002ycq.2	-	56	7676	c.7609G>A	c.(7609-7611)GAT>AAT	p.D2537N		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2537	Potential.|Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAGCAGCATCCTCGGCAGCC	0.697													0	0	0	0.009096	0	4	14										T	60891982	C	T	60891982	3	4	13	1	0	0	0	0	1	0	0	0	8609	855	30	1	3578	1	LAMA5	20	60891982	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	13200612	60891982	2133538	300	3490										
MORC3	23515	broad.mit.edu	37	chr21	37710178	37710178	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tgagcgtgggccttttgtctCagacctacttggaagtcata	11	9	2	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr21:37710178C>G	uc002yvi.2	+	4	470	c.394C>G	c.(394-396)CAG>GAG	p.Q132E		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	132					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						CCTTTTGTCTCAGACCTACTT	0.428													0	0	0	0.013114	0	41	87										G	37710178	C	G	37710178	3	3	13	1	0	0	0	0	1	0	0	0	9703	827	29	1	408	1	MORC3	21	37710178	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		37710178	10419717	301	3491										
PIGP	51227	broad.mit.edu	37	chr21	38444858	38444858	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctgtggaaaaggaacacaatCagcgccagcgatgtgctccg	12	11	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr21:38444858C>T	uc002yvw.1	-	1	246	c.30G>A	c.(28-30)CTG>CTA	p.L10L	TTC3_uc002yvz.2_5'Flank|TTC3_uc011aee.1_5'Flank|PIGP_uc002yvy.1_Intron|PIGP_uc002yvx.1_Intron|TTC3_uc011aed.1_5'Flank|TTC3_uc010gne.1_5'Flank	NM_153681	NP_710148	P57054	PIGP_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	10					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity				0		Myeloproliferative disorder(46;0.0412)				GGAACACAATCAGCGCCAGCG	0.577													0	0	0	0.007835	0	34	133										T	38444858	C	T	38444858	2	4	13	1	0	0	0	0	0	0	0	1	11895	813	29	1		1	PIGP	21	38444858	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	734680	38444858	9685037	302	3492										
COL18A1	80781	broad.mit.edu	37	chr21	46925183	46925183	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ccccttcatttcctggccctCacaggcagagtaagtcagtg	9	14	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr21:46925183C>T	uc011afs.1	+	35	4261	c.4240C>T	c.(4240-4242)CAC>TAC	p.H1414Y	COL18A1_uc002zhg.2_Missense_Mutation_p.H999Y|COL18A1_uc002zhi.2_Missense_Mutation_p.H1179Y|SLC19A1_uc010gpy.1_Intron|COL18A1_uc002zhj.2_5'UTR|COL18A1_uc002zhk.2_5'Flank	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1417	Nonhelical region 10 (NC10).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TCCTGGCCCTCACAGGCAGAG	0.697													0	0	0	0.014758	0	5	12										T	46925183	C	T	46925183	3	4	13	1	0	0	0	0	1	0	0	0	3675	826	29	1	4492	1	COL18A1	21	46925183	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	8480325	46925183	1204712	303	3493										
TXNRD2	10587	broad.mit.edu	37	chr22	19864662	19864662	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctgtcaccgtggggtccaggCctgagcgcttggagatgcgc	16	12	1	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:19864662C>A	uc011ahc.1	-	17	1574	c.1541G>T	c.(1540-1542)GGC>GTC	p.G514V	TXNRD2_uc002zql.1_Missense_Mutation_p.G268V|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Missense_Mutation_p.G513V|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_Missense_Mutation_p.G164V	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	514					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GGGGTCCAGGCCTGAGCGCTT	0.667													1	0	1.36491e-13	0.016723	1.49215e-13	12	6										A	19864662	C	A	19864662	3	1	13	1	0	0	0	0	1	0	0	0	16805	739	26	4	37	4	TXNRD2	22	19864662	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08		19864662	31439904	304	3494										
ARVCF	421	broad.mit.edu	37	chr22	19959927	19959927	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	acatcccggctgccagttttCtcgccctctgcaaggcagga	10	15	2	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:19959927C>G	uc002zqz.2	-	17	2920	c.2649G>C	c.(2647-2649)GAG>GAC	p.E883D	ARVCF_uc002zqy.2_Missense_Mutation_p.E399D	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	883					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TGCCAGTTTTCTCGCCCTCTG	0.647													0	0	0	0.004482	0	8	31										G	19959927	C	G	19959927	3	3	13	1	0	0	0	0	1	0	0	0	1003	912	32	1	251	1	ARVCF	22	19959927	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	95265	19959927	31344639	305	3495										
RTDR1	27156	broad.mit.edu	37	chr22	23482515	23482515	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tctgactgcagctcctccttCagcttgggcagggcccgatg	12	14	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:23482515C>T	uc002zwt.2	-	2	251	c.93G>A	c.(91-93)CTG>CTA	p.L31L	RTDR1_uc010gtv.1_Silent_p.L31L	NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	31							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GCTCCTCCTTCAGCTTGGGCA	0.562													0	0	0	0.00308	0	7	22										T	23482515	C	T	23482515	2	4	13	1	0	0	0	0	0	0	0	1	13719	813	29	1		1	RTDR1	22	23482515	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	3522588	23482515	27822051	306	3496										
TBC1D10A	83874	broad.mit.edu	37	chr22	30722669	30722669	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cggcgctactcacgcgccctCggcgccctgcgagcccacga	12	20	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:30722669C>T	uc011akt.1	-	1	226	c.202G>A	c.(202-204)GAG>AAG	p.E68K	TBC1D10A_uc010gvu.2_Missense_Mutation_p.E68K|TBC1D10A_uc003ahk.3_Missense_Mutation_p.E68K	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	68						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CACGCGCCCTCGGCGCCCTGC	0.716													0	0	0	0.014758	0	4	20										T	30722669	C	T	30722669	3	4	13	1	0	0	0	0	1	0	0	0	15595	893	31	1	1360	1	TBC1D10A	22	30722669	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	7240154	30722669	20581897	307	3497										
CACNG2	10369	broad.mit.edu	37	chr22	36960929	36960929	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgatgccaatgatgttactCagacctgcggggcgcagggt	14	9	1	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:36960929C>T	uc003aps.1	-	4	723	c.441G>A	c.(439-441)CTG>CTA	p.L147L		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	147	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						TGATGTTACTCAGACCTGCGG	0.557													0	0	0	0.01441	0	71	99										T	36960929	C	T	36960929	2	4	13	1	0	0	0	0	0	0	0	1	2557	813	29	1		1	CACNG2	22	36960929	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	6238260	36960929	14343637	308	3498										
RPL3	6122	broad.mit.edu	37	chr22	39708981	39708981	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tttgcaattcggtctttcttCagtggtccctgtggggagag	13	8	3	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:39708981C>T	uc003axi.2	-	10	1244	c.1176G>A	c.(1174-1176)CTG>CTA	p.L392L	RPL3_uc003axh.2_Silent_p.L343L|RPL3_uc003axj.2_Silent_p.L240L|RPL3_uc010gxx.2_Silent_p.L300L|RPL3_uc003axg.2_Silent_p.L340L	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	392					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					GGTCTTTCTTCAGTGGTCCCT	0.498													0	0	0	0.00308	0	8	27										T	39708981	C	T	39708981	2	4	13	1	0	0	0	0	0	0	0	1	13579	813	29	1		1	RPL3	22	39708981	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2748052	39708981	11595585	309	3499										
TNFRSF13C	115650	broad.mit.edu	37	chr22	42321519	42321519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gagctgtggcatcagagattCccggagacagaatgatgacc	13	9	1	5			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:42321519C>T	uc003bbl.2	-	3	451	c.407G>A	c.(406-408)GGA>GAA	p.G136E	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Missense_Mutation_p.G137E	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	136	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						ATCAGAGATTCCCGGAGACAG	0.637													0	0	0	0.021523	0	23	55										T	42321519	C	T	42321519	3	4	13	1	0	0	0	0	1	0	0	0	16285	855	30	1	151	1	TNFRSF13C	22	42321519	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2612538	42321519	8983047	310	3500										
A4GALT	53947	broad.mit.edu	37	chr22	43089310	43089310	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	aaggccaggaacgcgccgttGaggacgtagcgggactgggt	18	9	0	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:43089310G>A	uc003bdb.2	-	3	909	c.648C>T	c.(646-648)CTC>CTT	p.L216L	A4GALT_uc010gzd.2_Silent_p.L216L	NM_017436	NP_059132	Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	216	Lumenal (Potential).				glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			central_nervous_system(2)	2						ACGCGCCGTTGAGGACGTAGC	0.617													0	0	0	0.013537	0	11	32										A	43089310	G	A	43089310	2	1	13	1	0	0	0	0	0	0	0	1	6	1277	45	1		1	A4GALT	22	43089310	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	767791	43089310	8215256	311	3501										
BIK	638	broad.mit.edu	37	chr22	43520163	43520163	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ctggaccctatggaggacttCgattctttggaatgcatgga	12	8	1	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:43520163C>T	uc003bdk.2	+	2	195	c.135C>T	c.(133-135)TTC>TTT	p.F45F		NM_001197	NP_001188	Q13323	BIK_HUMAN	BCL2-interacting killer	45					apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane					0		Ovarian(80;0.0694)				TGGAGGACTTCGATTCTTTGG	0.567													0	0	0	0.017118	0	33	62										T	43520163	C	T	43520163	2	4	13	1	0	0	0	0	0	0	0	1	1431	883	31	1		1	BIK	22	43520163	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	430853	43520163	7784403	312	3502										
EFCAB6	64800	broad.mit.edu	37	chr22	43972201	43972201	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	tcaaggaaacagctaaagttCtggagaaaatatttccaatt	7	6	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:43972201C>T	uc003bdy.1	-	26	3611	c.3396G>A	c.(3394-3396)CAG>CAA	p.Q1132Q	EFCAB6_uc003bdz.1_Silent_p.Q980Q|EFCAB6_uc010gzi.1_Silent_p.Q980Q|EFCAB6_uc010gzj.1_Silent_p.Q358Q	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGCTAAAGTTCTGGAGAAAAT	0.313													0	0	0	0.016723	0	11	37										T	43972201	C	T	43972201	2	4	13	1	0	0	0	0	0	0	0	1	4939	912	32	1		1	EFCAB6	22	43972201	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	452038	43972201	7332365	313	3503										
GTSE1	51512	broad.mit.edu	37	chr22	46725395	46725395	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggatctgaaagcaggcctctGatcgacctcatgacaaacac	9	12	3	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chr22:46725395G>C	uc011aqy.1	+	11	2279	c.2067G>C	c.(2065-2067)CTG>CTC	p.L689L	GTSE1_uc011aqz.1_Silent_p.L536L|GTSE1_uc003bhn.2_RNA|uc011ara.1_5'Flank|uc003bho.3_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	670					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GCAGGCCTCTGATCGACCTCA	0.527													0	0	0	0.007835	0	43	80										C	46725395	G	C	46725395	2	2	13	1	0	0	0	0	0	0	0	1	6885	1277	45	1		1	GTSE1	22	46725395	Silent	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	2753194	46725395	4579171	314	3504										
ARSF	416	broad.mit.edu	37	chrX	3002367	3002367	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	atgggtttgactactactatGgcatgccgttcactctcgtt	9	10	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chrX:3002367G>A	uc004cre.1	+	6	711	c.490G>A	c.(490-492)GGC>AGC	p.G164S	ARSF_uc004crf.1_Missense_Mutation_p.G164S	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	164						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTACTACTATGGCATGCCGTT	0.512													0	0	0	0.017118	0	37	8										A	3002367	G	A	3002367	3	1	13	1	0	0	0	0	1	0	0	0	991	1348	47	2	508	2	ARSF	23	3002367	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08		3002367	152268193	315	3505										
CLCN4	1183	broad.mit.edu	37	chrX	10176604	10176604	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cactgatcttcaaaatcgtcGttaccatatttacctttggc	5	11	2	1			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chrX:10176604G>T	uc004csy.3	+	9	1793	c.1363G>T	c.(1363-1365)GTT>TTT	p.V455F	CLCN4_uc011mid.1_Missense_Mutation_p.V361F	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	455	Helical; (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CAAAATCGTCGTTACCATATT	0.527													1	0	2.09306e-48	0.01441	2.34109e-48	70	18										T	10176604	G	T	10176604	3	4	13	1	0	0	0	0	1	0	0	0	3465	1145	40	4	1389	4	CLCN4	23	10176604	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	7174237	10176604	145093956	316	3506										
KDM6A	7403	broad.mit.edu	37	chrX	44820575	44820575	+	Frame_Shift_Del	DEL	T	T	-													0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	cttaaaagctgaaggaaaagTggagtctgatttcttttgtc							TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08			T	-	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chrX:44820575delT	uc004dge.3	+	3	647	c.272delT	c.(271-273)GTGfs	p.V91fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.V91fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.V91fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.V91fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.V91fs|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	91					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(14)|p.0?(6)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GAAGGAAAAGTGGAGTCTGAT	0.289			D|N|F|S		renal|oesophageal SCC|MM													21	12	---	---								-	44820575	T	-	44820575	7	5	13	1	0	1	0	1	0	0	0	0	8137	1696	59	0	282	0	KDM6A	23	44820575	Frame_Shift_Del	DEL	T	TCGA-BT-A20T-01A-11D-A14W-08	34643971	44820575	110449985	317	3507										
RBMX2	51634	broad.mit.edu	37	chrX	129537824	129537824	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	ggacatcatctgtgtgttctCacagtaagtgtcctttcatt	8	9	4	0			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chrX:129537824C>T	uc004evt.2	+	3	234	c.170C>T	c.(169-171)TCA>TTA	p.S57L		NM_016024	NP_057108	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	57	RRM.						nucleotide binding|RNA binding			breast(3)|ovary(1)	4						TGTGTGTTCTCACAGTAAGTG	0.343													0	0	0	0.01441	0	88	120										T	129537824	C	T	129537824	3	4	13	1	0	0	0	0	1	0	0	0	13152	838	29	1	180	1	RBMX2	23	129537824	Missense_Mutation	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	84717249	129537824	25732736	318	3508										
USP26	83844	broad.mit.edu	37	chrX	132161712	132161712	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	gatgagagcattcttttcctCttcttgtgctgattttctga	8	8	4	3			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chrX:132161712C>T	uc010nrm.1	-	6	1007	c.537G>A	c.(535-537)AAG>AAA	p.K179K	USP26_uc011mvf.1_Silent_p.K179K	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	179					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					TTCTTTTCCTCTTCTTGTGCT	0.393													0	0	0	0.014323	0	21	42										T	132161712	C	T	132161712	2	4	13	1	0	0	0	0	0	0	0	1	17054	912	32	1		1	USP26	23	132161712	Silent	SNP	C	TCGA-BT-A20T-01A-11D-A14W-08	2623888	132161712	23108848	319	3509										
GDI1	2664	broad.mit.edu	37	chrX	153665607	153665607	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.492163009404389	157	7.52165665095139e-59	4.04760455205358	5.04654114660461	3.55099035933392	0.00439887355686586	0.0168192224233106	118	accgaggcctgaccatggacGaggaatacgatgtgatcgtg	14	9	0	2			TCGA-BT-A20T-01A-11D-A14W-08	TCGA-BT-A20T-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	301d6ce3-4099-4c1d-8e50-c04b7ce91450	e0fccaf5-925a-41f9-b87c-cd5ee4aecb59	g.chrX:153665607G>A	uc004fli.3	+	1	349	c.7G>A	c.(7-9)GAG>AAG	p.E3K	GDI1_uc011mzo.1_Missense_Mutation_p.E3K	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	3					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GACCATGGACGAGGAATACGA	0.552													0	0	0	0.004672	0	3	1										A	153665607	G	A	153665607	3	1	13	1	0	0	0	0	1	0	0	0	6320	1059	37	1	9	1	GDI1	23	153665607	Missense_Mutation	SNP	G	TCGA-BT-A20T-01A-11D-A14W-08	21503895	153665607	1604953	320	3510										
UBE2J2	118424	broad.mit.edu	37	chr1	1203256	1203256	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ccttaccactcgagaatattCgaagggaggggctcggcaca	12	11	0	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:1203256C>T	uc001adn.2	-	2	427	c.117G>A	c.(115-117)TCG>TCA	p.S39S	UBE2J2_uc001adm.2_5'UTR|UBE2J2_uc001ado.2_Silent_p.S39S|UBE2J2_uc001adp.2_Silent_p.S39S|UBE2J2_uc001adq.2_5'UTR|UBE2J2_uc001adr.2_Intron|UBE2J2_uc001ads.2_5'UTR	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	39	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		CGAGAATATTCGAAGGGAGGG	0.637													0	0	0	0.020292	0	15	205										T	1203256	C	T	1203256	2	4	14	1	0	0	0	0	0	0	0	1	16858	871	31	1		1	UBE2J2	1	1203256	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		1203256	248047365	1	3511										
LRRC47	57470	broad.mit.edu	37	chr1	3703763	3703763	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcagccgctgaccatcttctCcaggcgcttgtccctcagct	9	17	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:3703763C>A	uc001akx.1	-	2	755	c.727G>T	c.(727-729)GAG>TAG	p.E243*		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	243	LRR 7.				translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		ACCATCTTCTCCAGGCGCTTG	0.622													1	0	6.94344e-10	0.006122	7.72835e-10	16	47										A	3703763	C	A	3703763	4	1	14	1	0	0	0	0	0	1	0	0	9004	864	30	3	1048	3	LRRC47	1	3703763	Nonsense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	2500507	3703763	245546858	2	3512										
ATP13A2	23400	broad.mit.edu	37	chr1	17316492	17316492	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ggtgtagcttgcagcctggtCaggatcctgggggcccagga	17	10	1	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:17316492C>G	uc001baa.2	-	22	2609	c.2419G>C	c.(2419-2421)GAC>CAC	p.D807H	ATP13A2_uc001azz.1_5'UTR|ATP13A2_uc001bab.2_Missense_Mutation_p.D802H|ATP13A2_uc001bac.2_Intron	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	807	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		GCAGCCTGGTCAGGATCCTGG	0.647													0	0	0	0.001984	0	7	17										G	17316492	C	G	17316492	3	3	14	1	0	0	0	0	1	0	0	0	1124	826	29	1	1391	1	ATP13A2	1	17316492	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	13612729	17316492	231934129	3	3513										
LRRC41	10489	broad.mit.edu	37	chr1	46763283	46763283	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	agttcatcccagagtcggcgCcagatggcctgagttgagag	14	10	1	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:46763283C>T	uc001cpn.2	-	3	353	c.309G>A	c.(307-309)TGG>TGA	p.W103*	LRRC41_uc010omb.1_Nonsense_Mutation_p.W103*|LRRC41_uc001cpo.1_Nonsense_Mutation_p.W103*	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	103										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGAGTCGGCGCCAGATGGCCT	0.458													0	0	0	0.010729	0	11	43										T	46763283	C	T	46763283	4	4	14	1	0	0	0	0	0	1	0	0	8999	740	26	2	2161	2	LRRC41	1	46763283	Nonsense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	29446791	46763283	202487338	4	3514										
SLC5A9	200010	broad.mit.edu	37	chr1	48697274	48697274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gacggtgatcatggtaggggGagccctggtcctcatgtttc	15	9	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:48697274G>A	uc001cro.2	+	6	720	c.668G>A	c.(667-669)GGA>GAA	p.G223E	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Missense_Mutation_p.G248E|SLC5A9_uc010omt.1_Missense_Mutation_p.G237E|SLC5A9_uc001crp.2_5'UTR|SLC5A9_uc010omu.1_5'UTR	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	223	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						ATGGTAGGGGGAGCCCTGGTC	0.537													0	0	0	0.004482	0	9	23										A	48697274	G	A	48697274	3	1	14	1	0	0	0	0	1	0	0	0	14672	1174	41	1	769	1	SLC5A9	1	48697274	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	1933991	48697274	200553347	5	3515										
ALG6	29929	broad.mit.edu	37	chr1	63902557	63902557	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ctgtcacactggatcctcctCagaaactaccggacttgttt	7	13	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:63902557C>G	uc010oow.1	+	15	1695	c.1390C>G	c.(1390-1392)CAG>GAG	p.Q464E	ALG6_uc001daz.2_RNA|ALG6_uc009waj.2_RNA|ALG6_uc010oox.1_Missense_Mutation_p.Q211E	NM_013339	NP_037471	Q9Y672	ALG6_HUMAN	dolichyl pyrophosphate Man9GlcNAc2	464					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0						GGATCCTCCTCAGAAACTACC	0.373													0	0	0	0.015359	0	31	126										G	63902557	C	G	63902557	3	3	14	1	0	0	0	0	1	0	0	0	522	827	29	1	1444	1	ALG6	1	63902557	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	15205283	63902557	185348064	6	3516										
LPHN2	23266	broad.mit.edu	37	chr1	82451025	82451025	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aggtgacatcaatagcacttCaacacttaatcaaggtcagt	7	9	4	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:82451025C>G	uc001dit.3	+	20	3624	c.3443C>G	c.(3442-3444)TCA>TGA	p.S1148*	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Nonsense_Mutation_p.S1148*|LPHN2_uc001div.2_Nonsense_Mutation_p.S1148*|LPHN2_uc009wcd.2_Intron|LPHN2_uc001diw.2_Nonsense_Mutation_p.S732*	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1161	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AATAGCACTTCAACACTTAAT	0.289													0	0	0	0.009096	0	4	13										G	82451025	C	G	82451025	4	3	14	1	0	0	0	0	0	1	0	0	8916	838	29	1	3513	1	LPHN2	1	82451025	Nonsense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	18548468	82451025	166799596	7	3517										
COL24A1	255631	broad.mit.edu	37	chr1	86252137	86252137	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ctgttcttcctgggccgcctCtgatgccctaaataacacag	8	14	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:86252137C>G	uc001dlj.2	-	48	4001	c.3959G>C	c.(3958-3960)AGA>ACA	p.R1320T	COL24A1_uc001dli.2_Missense_Mutation_p.R456T|COL24A1_uc010osd.1_Missense_Mutation_p.R620T|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1320	Collagen-like 15.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TGGGCCGCCTCTGATGCCCTA	0.478													0	0	0	0.008291	0	11	34										G	86252137	C	G	86252137	3	3	14	1	0	0	0	0	1	0	0	0	3683	913	32	1	1237	1	COL24A1	1	86252137	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	3801112	86252137	162998484	8	3518										
HCN3	57657	broad.mit.edu	37	chr1	155252454	155252454	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	acctggttcctggttgacctCatctcttctatccctgtgga	8	13	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:155252454C>T	uc001fjz.1	+	2	539	c.531C>T	c.(529-531)CTC>CTT	p.L177L	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_5'UTR	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	177	Helical; Name=Segment S3; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTTGACCTCATCTCTTCTA	0.607													0	0	0	0.016723	0	12	70										T	155252454	C	T	155252454	2	4	14	1	0	0	0	0	0	0	0	1	6998	813	29	1		1	HCN3	1	155252454	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	69000317	155252454	93998167	9	3519										
RUSC1	23623	broad.mit.edu	37	chr1	155292388	155292388	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgaacctgaaaaattcgactCtggttggaaaaccaacacaa	7	9	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:155292388C>G	uc001fkj.2	+	2	1053	c.824C>G	c.(823-825)TCT>TGT	p.S275C	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.S275C|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	275						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			AAATTCGACTCTGGTTGGAAA	0.428													0	0	0	0.00308	0	8	142										G	155292388	C	G	155292388	3	3	14	1	0	0	0	0	1	0	0	0	13750	913	32	1	826	1	RUSC1	1	155292388	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	39934	155292388	93958233	10	3520										
ATP1A4	480	broad.mit.edu	37	chr1	160156121	160156121	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ttctcatcttcgtctatgatGaaatcagaaaactcctcatc	4	11	5	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:160156121G>A	uc001fve.3	+	21	3504	c.3025G>A	c.(3025-3027)GAA>AAA	p.E1009K	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.E512K|ATP1A4_uc001fvh.2_Missense_Mutation_p.E145K	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	1009	Helical; (Potential).			ITWWLCAIPYSILIFVYDEIRKLLIRQ -> WSFALTAQAG VKWRILGLLQPLPPRFK (in Ref. 6; BAC05228).	ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CGTCTATGATGAAATCAGAAA	0.557													0	0	0	0.01441	0	52	214										A	160156121	G	A	160156121	3	1	14	1	0	0	0	0	1	0	0	0	1131	1291	45	1	3107	1	ATP1A4	1	160156121	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	4863733	160156121	89094500	11	3521										
MYOC	4653	broad.mit.edu	37	chr1	171621749	171621749	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	caacgtgcacagaagaacctCattgcagaggcttggtgagg	13	9	1	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:171621749C>T	uc001ghu.2	-	1	25	c.3G>A	c.(1-3)ATG>ATA	p.M1I	MYOC_uc010pmk.1_Missense_Mutation_p.M1I	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	1					anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGAAGAACCTCATTGCAGAGG	0.612													0	0	0	0.00308	0	7	18										T	171621749	C	T	171621749	3	4	14	1	0	0	0	0	1	0	0	0	10086	826	29	1	1523	1	MYOC	1	171621749	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	11465628	171621749	77628872	12	3522										
PLEKHA6	22874	broad.mit.edu	37	chr1	204228731	204228731	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cttctggcctctcaggccttCtctctgccttctcacagcct	6	18	5	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:204228731C>G	uc001hau.2	-	8	979	c.662G>C	c.(661-663)AGA>ACA	p.R221T	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	221	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			CTCAGGCCTTCTCTCTGCCTT	0.637													0	0	0	0.004007	0	14	56										G	204228731	C	G	204228731	3	3	14	1	0	0	0	0	1	0	0	0	12060	913	32	1	2544	1	PLEKHA6	1	204228731	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	32606982	204228731	45021890	13	3523										
RYR2	6262	broad.mit.edu	37	chr1	237881784	237881784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	agataccgaggatgaagtacGagatataatccgcagcaata	10	7	0	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:237881784G>A	uc001hyl.1	+	73	10637	c.10517G>A	c.(10516-10518)CGA>CAA	p.R3506Q	RYR2_uc010pxz.1_Missense_Mutation_p.R461Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3506					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATGAAGTACGAGATATAATC	0.333													0	0	0	0.004482	0	9	17										A	237881784	G	A	237881784	3	1	14	1	0	0	0	0	1	0	0	0	13769	1058	37	1	10807	1	RYR2	1	237881784	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	33653053	237881784	11368837	14	3524										
HNRNPU	3192	broad.mit.edu	37	chr1	245017797	245017797	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgactccatggcttctgaccCcagaattgctgtaagagaaa	9	10	1	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:245017797C>G	uc001iaz.1	-	14	2651	c.2433G>C	c.(2431-2433)TGG>TGC	p.W811C	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.W535C|HNRNPU_uc001iba.1_Missense_Mutation_p.W792C	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	811	Gly-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			GCTTCTGACCCCAGAATTGCT	0.328													0	0	0	0.016723	0	10	38										G	245017797	C	G	245017797	3	3	14	1	0	0	0	0	1	0	0	0	7273	624	22	4	48	4	HNRNPU	1	245017797	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	7136013	245017797	4232824	15	3525										
KIF26B	55083	broad.mit.edu	37	chr1	245809541	245809541	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ctgtctgctctgggcaatgtCatcctggctctcgtcaatgg	11	12	5	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr1:245809541C>T	uc001ibf.1	+	10	2657	c.2217C>T	c.(2215-2217)GTC>GTT	p.V739V	KIF26B_uc010pyq.1_Silent_p.V739V|KIF26B_uc001ibg.1_Silent_p.V357V|KIF26B_uc001ibh.1_5'UTR	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	739	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TGGGCAATGTCATCCTGGCTC	0.502													0	0	0	0.001168	0	6	30										T	245809541	C	T	245809541	2	4	14	1	0	0	0	0	0	0	0	1	8295	813	29	1		1	KIF26B	1	245809541	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	791744	245809541	3441080	16	3526										
RETSAT	54884	broad.mit.edu	37	chr2	85577947	85577947	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aatgatagcttcctcctgtgGaaacttctccttgaggccct	8	12	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr2:85577947G>C	uc002spd.2	-	3	744	c.553C>G	c.(553-555)CCA>GCA	p.P185A	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.P124A|RETSAT_uc010fgf.2_Intron	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	185					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	TCCTCCTGTGGAAACTTCTCC	0.468													0	0	0	0.001168	0	6	152										C	85577947	G	C	85577947	3	2	14	1	0	0	0	0	1	0	0	0	13238	1174	41	1	1315	1	RETSAT	2	85577947	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		85577947	157621426	17	3527										
EIF2AK3	9451	broad.mit.edu	37	chr2	88888374	88888374	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gacttgaaggaaacttttctGaaattctgactgatgactgc	9	7	2	5			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr2:88888374G>A	uc002stc.3	-	7	1413	c.1211C>T	c.(1210-1212)TCA>TTA	p.S404L		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	404	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						AAACTTTTCTGAAATTCTGAC	0.338													0	0	0	0.00632	0	25	78										A	88888374	G	A	88888374	3	1	14	1	0	0	0	0	1	0	0	0	4998	1294	45	1	2183	1	EIF2AK3	2	88888374	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	3310427	88888374	154310999	18	3528										
NFE2L2	4780	broad.mit.edu	37	chr2	178098954	178098954	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aaatacttctcgacttactcCaagatctatatcttgcctcc	3	13	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr2:178098954C>T	uc002ulh.3	-	2	646	c.91G>A	c.(91-93)GGA>AGA	p.G31R	NFE2L2_uc002ulg.3_Missense_Mutation_p.G15R|NFE2L2_uc010zfa.1_Missense_Mutation_p.G15R|NFE2L2_uc002uli.3_Missense_Mutation_p.G15R|NFE2L2_uc010fra.2_Missense_Mutation_p.G15R|NFE2L2_uc010frb.2_Missense_Mutation_p.G15R	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	31					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G31R(1)		central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			CGACTTACTCCAAGATCTATA	0.358			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.010729	0	11	35										T	178098954	C	T	178098954	3	4	14	1	0	0	0	0	1	0	0	0	10368	603	21	2	1742	2	NFE2L2	2	178098954	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	89210580	178098954	65100419	19	3529										
AOX1	316	broad.mit.edu	37	chr2	201515748	201515748	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	atcaaacaccctacaaacaaGagatcaatgccaagaaccta	4	12	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr2:201515748G>A	uc002uvx.2	+	26	3000	c.2899G>A	c.(2899-2901)GAG>AAG	p.E967K	AOX1_uc010zhf.1_Missense_Mutation_p.E523K|AOX1_uc010fsu.2_Missense_Mutation_p.E333K	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	967					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CTACAAACAAGAGATCAATGC	0.418													0	0	0	0.003163	0	13	79										A	201515748	G	A	201515748	3	1	14	1	0	0	0	0	1	0	0	0	729	943	33	1	3001	1	AOX1	2	201515748	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	23416794	201515748	41683625	20	3530										
SETD5	55209	broad.mit.edu	37	chr3	9483388	9483388	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	atcgtgggaaagtcatgttaCgacagcaatttgaggtcaat	11	6	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:9483388C>T	uc003brt.2	+	9	1357	c.922C>T	c.(922-924)CGA>TGA	p.R308*	SETD5_uc003brs.1_Nonsense_Mutation_p.R289*|SETD5_uc003bru.2_Nonsense_Mutation_p.R210*|SETD5_uc003brv.2_Nonsense_Mutation_p.R197*|SETD5_uc010hck.2_5'Flank|SETD5_uc003brw.1_5'Flank|SETD5_uc003brx.2_5'Flank	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	308	SET.									ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGTCATGTTACGACAGCAATT	0.443													0	0	0	0.004007	0	14	80										T	9483388	C	T	9483388	4	4	14	1	0	0	0	0	0	1	0	0	14134	528	19	2	948	2	SETD5	3	9483388	Nonsense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		9483388	188539042	21	3531										
SCN11A	11280	broad.mit.edu	37	chr3	38888407	38888407	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	actatgggttcatacaacttCttgagaggattggcttccat	9	8	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:38888407C>G	uc011ays.1	-	26	5353	c.5154G>C	c.(5152-5154)AAG>AAC	p.K1718N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1718					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CATACAACTTCTTGAGAGGAT	0.433													0	0	0	0.021022	0	35	145										G	38888407	C	G	38888407	3	3	14	1	0	0	0	0	1	0	0	0	13913	912	32	1	225	1	SCN11A	3	38888407	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	29405019	38888407	159134023	22	3532										
ALCAM	214	broad.mit.edu	37	chr3	105243325	105243325	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	taactgaggacaacgtgtttGaggcacctacaatagtcaag	10	8	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:105243325G>A	uc003dvx.2	+	3	907	c.367G>A	c.(367-369)GAG>AAG	p.E123K	ALCAM_uc003dvv.2_Missense_Mutation_p.E123K|ALCAM_uc003dvw.1_Missense_Mutation_p.E123K|ALCAM_uc003dvy.2_Missense_Mutation_p.E123K|ALCAM_uc011bhh.1_Missense_Mutation_p.E72K	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	123	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						CAACGTGTTTGAGGCACCTAC	0.418													0	0	0	0.012319	0	21	64										A	105243325	G	A	105243325	3	1	14	1	0	0	0	0	1	0	0	0	487	1291	45	1	377	1	ALCAM	3	105243325	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	66354918	105243325	92779105	23	3533										
C3orf15	89876	broad.mit.edu	37	chr3	119451310	119451310	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gtagtaaaaaactactatctCaacacctatgaaggtaagca	6	8	1	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:119451310C>G	uc003ede.3	+	9	1265	c.1188C>G	c.(1186-1188)CTC>CTG	p.L396L	C3orf15_uc010hqy.1_Silent_p.L396L|C3orf15_uc010hqz.2_Silent_p.L334L|C3orf15_uc011bjd.1_Silent_p.L270L|C3orf15_uc011bje.1_Silent_p.L376L|C3orf15_uc010hra.1_Silent_p.L157L	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	Error:Variant_position_missing_in_Q7Z4T9_after_alignment						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		ACTACTATCTCAACACCTATG	0.323													0	0	0	0.004482	0	9	19										G	119451310	C	G	119451310	2	3	14	1	0	0	0	0	0	0	0	1	2209	813	29	1		1	C3orf15	3	119451310	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	14207985	119451310	78571120	24	3534										
GK5	256356	broad.mit.edu	37	chr3	141889249	141889249	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tctatattctcattaatcagGtctgaagtcatctgcatgac	6	9	6	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:141889249G>A	uc003euq.1	-	15	1490	c.1359C>T	c.(1357-1359)GAC>GAT	p.D453D	GK5_uc003eup.1_Silent_p.D174D|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	453					glycerol metabolic process		ATP binding|glycerol kinase activity				0						CATTAATCAGGTCTGAAGTCA	0.408													0	0	0	0.009096	0	4	64										A	141889249	G	A	141889249	2	1	14	1	0	0	0	0	0	0	0	1	6422	1252	44	2		2	GK5	3	141889249	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	22437939	141889249	56133181	25	3535										
MBNL1	4154	broad.mit.edu	37	chr3	152018007	152018007	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ctgttagtgtcacaccaattCgggacacaaaatggctaaca	8	10	1	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:152018007C>T	uc003ezm.2	+	1	814	c.25C>T	c.(25-27)CGG>TGG	p.R9W	MBNL1_uc003ezh.2_Missense_Mutation_p.R9W|MBNL1_uc003ezi.2_Missense_Mutation_p.R9W|MBNL1_uc003ezj.2_Intron|MBNL1_uc003ezl.2_Missense_Mutation_p.R9W|MBNL1_uc003ezp.2_Missense_Mutation_p.R9W|MBNL1_uc003ezn.2_Missense_Mutation_p.R9W|MBNL1_uc003ezo.2_Missense_Mutation_p.R9W|MBNL1_uc003ezg.1_RNA|MBNL1_uc003ezk.1_RNA	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	9					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			CACACCAATTCGGGACACAAA	0.438													0	0	0	0.004007	0	14	49										T	152018007	C	T	152018007	3	4	14	1	0	0	0	0	1	0	0	0	9353	875	31	1	27	1	MBNL1	3	152018007	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	10128758	152018007	46004423	26	3536										
TBL1XR1	79718	broad.mit.edu	37	chr3	176752109	176752109	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aattgtcttgtttcatactcCatatctaaacaaaaaagaaa	3	7	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:176752109C>A	uc003fiw.3	-	13	1387	c.1127G>T	c.(1126-1128)TGG>TTG	p.W376L	TBL1XR1_uc003fix.3_Missense_Mutation_p.W376L|TBL1XR1_uc011bpz.1_Missense_Mutation_p.W48L	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	376	WD 5.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			TTTCATACTCCATATCTAAAC	0.269													1	0	0.00116845	0.001168	0.00123604	6	13										A	176752109	C	A	176752109	3	1	14	1	0	0	0	0	1	0	0	0	15637	595	21	4	433	4	TBL1XR1	3	176752109	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	24734102	176752109	21270321	27	3537										
TP63	8626	broad.mit.edu	37	chr3	189526295	189526303	+	In_Frame_Del	DEL	GCCAAGTCG	GCCAAGTCG	-													0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ccttccagcagtcgagcaccGccaagtcggccacctggacg							TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr3:189526295_189526303delGCCAAGTCG	uc003fry.2	+	4	648_656	c.559_567delGCCAAGTCG	c.(559-567)GCCAAGTCGdel	p.AKS187del	TP63_uc003frx.2_In_Frame_Del_p.AKS187del|TP63_uc003frz.2_In_Frame_Del_p.AKS187del|TP63_uc010hzc.1_In_Frame_Del_p.AKS187del|TP63_uc003fsa.2_In_Frame_Del_p.AKS93del|TP63_uc003fsb.2_In_Frame_Del_p.AKS93del|TP63_uc003fsc.2_In_Frame_Del_p.AKS93del|TP63_uc003fsd.2_In_Frame_Del_p.AKS93del|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_In_Frame_Del_p.AKS68del	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	187_189					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTCGAGCACCGCCAAGTCGGCCACCTGGA	0.622									Hay-Wells_syndrome	HNSCC(45;0.13)								9	45	---	---								-	189526303	GCCAAGTCG	-	189526295	7	5	14	1	0	1	0	1	0	0	0	0	16389	1087	38	0	619	0	TP63	3	189526295	In_Frame_Del	DEL	GCCAAGTCG	TCGA-BT-A20U-01A-11D-A14W-08	12774186	189526295	8496135	28	3538										
EVC2	132884	broad.mit.edu	37	chr4	5633669	5633669	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tctgtgagctttggcaaagtCttcttcttgttgcaaagcga	10	8	4	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr4:5633669C>T	uc003gij.2	-	11	1615	c.1561G>A	c.(1561-1563)GAC>AAC	p.D521N	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.D441N	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	521	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						TTGGCAAAGTCTTCTTCTTGT	0.468													0	0	0	0.014758	0	5	89										T	5633669	C	T	5633669	3	4	14	1	0	0	0	0	1	0	0	0	5286	913	32	1	2413	1	EVC2	4	5633669	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		5633669	185520607	29	3539										
RFC1	5981	broad.mit.edu	37	chr4	39290425	39290425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tccttttctgggctccttatCtttttctggttttgaaggct	8	9	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr4:39290425C>G	uc003gty.1	-	25	3537	c.3403G>C	c.(3403-3405)GAT>CAT	p.D1135H	RFC1_uc003gtx.1_Missense_Mutation_p.D1134H	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	1135					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						GGCTCCTTATCTTTTTCTGGT	0.363													0	0	0	0.006122	0	17	50										G	39290425	C	G	39290425	3	3	14	1	0	0	0	0	1	0	0	0	13244	913	32	1	47	1	RFC1	4	39290425	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	33656756	39290425	151863851	30	3540										
FAT1	2195	broad.mit.edu	37	chr4	187549509	187549509	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcgttttacaggcacatcttGatctcgtacctaaaaagaat	7	9	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr4:187549509G>A	uc003izf.2	-	9	4797	c.4609C>T	c.(4609-4611)CAA>TAA	p.Q1537*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1537	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGCACATCTTGATCTCGTACC	0.458										HNSCC(5;0.00058)			0	0	0	0.004482	0	7	9										A	187549509	G	A	187549509	4	1	14	1	0	0	0	0	0	1	0	0	5689	1299	45	1	9233	1	FAT1	4	187549509	Nonsense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	148259084	187549509	3604767	31	3541										
FAT1	2195	broad.mit.edu	37	chr4	187549807	187549807	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcatcctgatccacagcactGatttgcaaaatttctgtttc	5	11	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr4:187549807G>T	uc003izf.2	-	8	4622	c.4434C>A	c.(4432-4434)ATC>ATA	p.I1478I		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1478	Extracellular (Potential).|Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCACAGCACTGATTTGCAAAA	0.398										HNSCC(5;0.00058)			1	0	4.96729e-08	0.008871	5.48115e-08	20	25										T	187549807	G	T	187549807	2	4	14	1	0	0	0	0	0	0	0	1	5689	1280	45	3		3	FAT1	4	187549807	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	298	187549807	3604469	32	3542										
CTNND2	1501	broad.mit.edu	37	chr5	11346575	11346575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ggatttgctgtatggagactCaacagagggacaatactgca	12	7	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr5:11346575C>T	uc003jfa.1	-	9	1682	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K	CTNND2_uc010itt.2_Missense_Mutation_p.E422K|CTNND2_uc011cmy.1_Missense_Mutation_p.E176K|CTNND2_uc011cmz.1_Missense_Mutation_p.E80K|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.E80K	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	513					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TATGGAGACTCAACAGAGGGA	0.607													0	0	0	0.009535	0	26	96										T	11346575	C	T	11346575	3	4	14	1	0	0	0	0	1	0	0	0	4020	835	29	1	2196	1	CTNND2	5	11346575	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		11346575	169568685	33	3543										
VCAN	1462	broad.mit.edu	37	chr5	82868358	82868358	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cctgcaattaccatctcaccTatacgtgcaagaaaggaaca	6	12	1	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr5:82868358T>G	uc003kii.3	+	13	10215	c.9859T>G	c.(9859-9861)TAT>GAT	p.Y3287D	VCAN_uc003kij.3_Missense_Mutation_p.Y2300D|VCAN_uc010jau.2_Missense_Mutation_p.Y1533D|VCAN_uc003kik.3_Missense_Mutation_p.Y546D|VCAN_uc003kil.3_Missense_Mutation_p.Y1951D	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3287	C-type lectin.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCATCTCACCTATACGTGCAA	0.383													0	0	0	0.013537	0	12	47										G	82868358	T	G	82868358	3	3	14	1	0	0	0	0	1	0	0	0	17135	1522	53	5	9905	5	VCAN	5	82868358	Missense_Mutation	SNP	T	TCGA-BT-A20U-01A-11D-A14W-08	71521783	82868358	98046902	34	3544										
F12	2161	broad.mit.edu	37	chr5	176833003	176833003	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcccttgtgggtacatttgtGgtacagctgccggtggtact	14	9	0	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr5:176833003G>A	uc003mgo.3	-	3	224	c.175C>T	c.(175-177)CAC>TAC	p.H59Y	F12_uc011dfy.1_5'Flank|F12_uc003mgn.3_5'Flank|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	59	Fibronectin type-II.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTACATTTGTGGTACAGCTGC	0.607									Hereditary_Angioedema				0	0	0	0.019004	0	32	112										A	176833003	G	A	176833003	3	1	14	1	0	0	0	0	1	0	0	0	5339	1348	47	2	1720	2	F12	5	176833003	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	93964645	176833003	4082257	35	3545										
BTN3A3	10384	broad.mit.edu	37	chr6	26452381	26452381	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gagcctctatatcctgttttCagaattttgaccttggagcc	8	10	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr6:26452381C>T	uc003nhz.2	+	11	1677	c.1497C>T	c.(1495-1497)TTC>TTT	p.F499F	BTN3A3_uc003nia.2_Silent_p.F457F|BTN3A3_uc011dkn.1_Silent_p.F450F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	499	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						ATCCTGTTTTCAGAATTTTGA	0.478													0	0	0	0.001168	0	5	124										T	26452381	C	T	26452381	2	4	14	1	0	0	0	0	0	0	0	1	1564	825	29	1		1	BTN3A3	6	26452381	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		26452381	144662686	36	3546										
ORC3L	23595	broad.mit.edu	37	chr6	88317511	88317511	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gacacattattcaatggattCactttccagttggtatatga	7	7	2	1	rs149324991	byFrequency	TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr6:88317511C>T	uc003pmh.2	+	6	592	c.548C>T	c.(547-549)TCA>TTA	p.S183L	ORC3L_uc011dzl.1_Missense_Mutation_p.S183L|ORC3L_uc011dzm.1_Missense_Mutation_p.S183L|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Missense_Mutation_p.S183L|ORC3L_uc003pmi.2_Missense_Mutation_p.S183L|ORC3L_uc011dzo.1_Missense_Mutation_p.S40L|ORC3L_uc011dzp.1_Missense_Mutation_p.S40L	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	183					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		TCAATGGATTCACTTTCCAGT	0.373													0	0	0	0.01892	0	23	65										T	88317511	C	T	88317511	3	4	14	1	0	0	0	0	1	0	0	0	11263	838	29	1	570	1	ORC3L	6	88317511	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	61865130	88317511	82797556	37	3547										
BCLAF1	9774	broad.mit.edu	37	chr6	136599223	136599223	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	agacctttcaggactatgctGaatggaatgtgaatgctgag	12	6	1	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr6:136599223G>A	uc003qgx.1	-	4	1049	c.796C>T	c.(796-798)CAG>TAG	p.Q266*	BCLAF1_uc003qgw.1_Nonsense_Mutation_p.Q266*|BCLAF1_uc003qgy.1_Nonsense_Mutation_p.Q264*|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Nonsense_Mutation_p.Q264*	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	266					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GGACTATGCTGAATGGAATGT	0.448													0	0	0	0.014758	0	5	38										A	136599223	G	A	136599223	4	1	14	1	0	0	0	0	0	1	0	0	1383	1299	45	1	2006	1	BCLAF1	6	136599223	Nonsense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	48281712	136599223	34515844	38	3548										
UTRN	7402	broad.mit.edu	37	chr6	144803379	144803379	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgtgttgcagaaggaggtgaGagtgaagattctcaaggaca	15	4	1	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr6:144803379G>A	uc003qkt.2	+	26	3634	c.3542G>A	c.(3541-3543)AGA>AAA	p.R1181K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1181	Spectrin 8.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AAGGAGGTGAGAGTGAAGATT	0.453													0	0	0	0.008291	0	9	33										A	144803379	G	A	144803379	3	1	14	1	0	0	0	0	1	0	0	0	17100	942	33	1	3644	1	UTRN	6	144803379	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	8204156	144803379	26311688	39	3549										
LANCL2	55915	broad.mit.edu	37	chr7	55459492	55459492	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cttttggatctcagatcattCataatttcataagacggatc	6	8	4	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr7:55459492C>G	uc003tqp.2	+	2	789	c.211C>G	c.(211-213)CAT>GAT	p.H71D		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	71					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TCAGATCATTCATAATTTCAT	0.363													0	0	0	0.013537	0	12	27										G	55459492	C	G	55459492	3	3	14	1	0	0	0	0	1	0	0	0	8621	826	29	1	217	1	LANCL2	7	55459492	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		55459492	103679171	40	3550										
PION	54103	broad.mit.edu	37	chr7	77010667	77010667	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	acatggatacgaaattgttcAatatctttaaaagaaaaaca	5	5	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr7:77010667A>G	uc003ugf.2	-	8	610	c.531T>C	c.(529-531)ATT>ATC	p.I177I	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	177					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						GAAATTGTTCAATATCTTTAA	0.289													0	0	0	0.001984	0	5	24										G	77010667	A	G	77010667	2	3	14	1	0	0	0	0	0	0	0	1	11934	126	5	5		5	PION	7	77010667	Silent	SNP	A	TCGA-BT-A20U-01A-11D-A14W-08	21551175	77010667	82127996	41	3551										
MET	4233	broad.mit.edu	37	chr7	116409705	116409705	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ttttttcctttcagggaaatGatattgaccctgaagcagtt	8	7	1	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr7:116409705G>A	uc003vij.2	+	12	2777	c.2590G>A	c.(2590-2592)GAT>AAT	p.D864N	MET_uc010lkh.2_Missense_Mutation_p.D882N|MET_uc011knj.1_Missense_Mutation_p.D434N	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	864	Extracellular (Potential).				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TCAGGGAAATGATATTGACCC	0.358			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.016723	0	14	42										A	116409705	G	A	116409705	3	1	14	1	0	0	0	0	1	0	0	0	9485	1290	45	1	2686	1	MET	7	116409705	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	39399038	116409705	42728958	42	3552										
SGK223	157285	broad.mit.edu	37	chr8	8185504	8185504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cagctgaagctgggtgctccCggtggaggcttgactggaca	16	10	0	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr8:8185504C>T	uc003wsh.3	-	4	2788	c.2788G>A	c.(2788-2790)GGG>AGG	p.G930R		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	930							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TGGGTGCTCCCGGTGGAGGCT	0.677													0	0	0	0.003163	0	14	47										T	8185504	C	T	8185504	3	4	14	1	0	0	0	0	1	0	0	0	14210	652	23	2	1428	2	SGK223	8	8185504	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		8185504	138178518	43	3553										
MCM4	4173	broad.mit.edu	37	chr8	48874100	48874100	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gagtgaggatgccaggtcatCtccctctcagagacgtagag	13	10	3	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr8:48874100C>G	uc003xqk.1	+	3	190	c.95C>G	c.(94-96)TCT>TGT	p.S32C	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.S32C|MCM4_uc011ldi.1_Missense_Mutation_p.S32C|MCM4_uc010lxw.1_RNA	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	32					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GCCAGGTCATCTCCCTCTCAG	0.577													0	0	0	0.007413	0	16	37										G	48874100	C	G	48874100	3	3	14	1	0	0	0	0	1	0	0	0	9389	913	32	1	101	1	MCM4	8	48874100	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	40688596	48874100	97489922	44	3554										
TM7SF4	81501	broad.mit.edu	37	chr8	105361016	105361016	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gtgttgctccaagcatgcacGatgttttattcttcttgtct	8	9	3	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr8:105361016G>A	uc003ylx.1	+	2	285	c.236G>A	c.(235-237)CGA>CAA	p.R79Q		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	79					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAGCATGCACGATGTTTTATT	0.522													0	0	0	0.004007	0	17	65										A	105361016	G	A	105361016	3	1	14	1	0	0	0	0	1	0	0	0	15973	1058	37	1	238	1	TM7SF4	8	105361016	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	56486916	105361016	41003006	45	3555										
CNTLN	54875	broad.mit.edu	37	chr9	17464544	17464544	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgaaaagacatttgatagagGacttgaaatttcgacagaaa	9	4	0	6			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr9:17464544G>C	uc003zmz.2	+	21	3477	c.3451G>C	c.(3451-3453)GAC>CAC	p.D1151H	CNTLN_uc003zmy.2_Missense_Mutation_p.D1152H|CNTLN_uc010mio.2_Missense_Mutation_p.D831H	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1152	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		TTTGATAGAGGACTTGAAATT	0.294													0	0	0	0.001168	0	5	20										C	17464544	G	C	17464544	3	2	14	1	0	0	0	0	1	0	0	0	3639	1174	41	1	3566	1	CNTLN	9	17464544	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		17464544	123748887	46	3556										
ARHGAP12	94134	broad.mit.edu	37	chr10	32098165	32098165	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aatataatcttaccatgattGactgcaaaccttagtttctg	5	8	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr10:32098165G>A	uc001ivz.1	-	17	2391	c.2121C>T	c.(2119-2121)GTC>GTT	p.V707V	ARHGAP12_uc001ivy.1_Silent_p.V653V|ARHGAP12_uc009xls.2_Silent_p.V658V|ARHGAP12_uc001iwb.1_Silent_p.V700V|ARHGAP12_uc001iwc.1_Silent_p.V675V|ARHGAP12_uc009xlq.1_Silent_p.V628V|ARHGAP12_uc001ivw.1_5'Flank|ARHGAP12_uc001ivx.1_5'UTR	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	707	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TACCATGATTGACTGCAAACC	0.343													0	0	0	0.009096	0	4	33										A	32098165	G	A	32098165	2	1	14	1	0	0	0	0	0	0	0	1	865	1277	45	1		1	ARHGAP12	10	32098165	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		32098165	103436582	47	3557										
MAPK8	5599	broad.mit.edu	37	chr10	49633981	49633981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	agcttggaacaccatgtcctGaattcatgaagaaactgcaa	8	9	1	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr10:49633981G>C	uc009xnz.2	+	8	963	c.739G>C	c.(739-741)GAA>CAA	p.E247Q	MAPK8_uc001jgl.2_Missense_Mutation_p.E247Q|MAPK8_uc001jgm.2_Missense_Mutation_p.E247Q|MAPK8_uc001jgo.2_Missense_Mutation_p.E247Q|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.E247Q|MAPK8_uc010qgk.1_Missense_Mutation_p.E247Q|MAPK8_uc001jgp.2_Missense_Mutation_p.E247Q|MAPK8_uc001jgq.2_Missense_Mutation_p.E247Q	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	247	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding	p.E247*(1)		central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		ACCATGTCCTGAATTCATGAA	0.343													0	0	0	0.004482	0	7	45										C	49633981	G	C	49633981	3	2	14	1	0	0	0	0	1	0	0	0	9283	1291	45	1	841	1	MAPK8	10	49633981	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	17535816	49633981	85900766	48	3558										
MAPK8	5599	broad.mit.edu	37	chr10	49634089	49634089	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ctgatgtccttttcccagctGactcagaacacaacaaactt	5	13	1	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr10:49634089G>C	uc009xnz.2	+	8	1071	c.847G>C	c.(847-849)GAC>CAC	p.D283H	MAPK8_uc001jgl.2_Missense_Mutation_p.D283H|MAPK8_uc001jgm.2_Missense_Mutation_p.D283H|MAPK8_uc001jgo.2_Missense_Mutation_p.D283H|MAPK8_uc009xoa.2_Missense_Mutation_p.D207H|MAPK8_uc001jgn.2_Missense_Mutation_p.D283H|MAPK8_uc010qgk.1_Missense_Mutation_p.D283H|MAPK8_uc001jgp.2_Missense_Mutation_p.D283H|MAPK8_uc001jgq.2_Missense_Mutation_p.D283H	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	283	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		TTTCCCAGCTGACTCAGAACA	0.378													0	0	0	0.001168	0	4	61										C	49634089	G	C	49634089	3	2	14	1	0	0	0	0	1	0	0	0	9283	1290	45	1	949	1	MAPK8	10	49634089	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	108	49634089	85900658	49	3559										
CDK1	983	broad.mit.edu	37	chr10	62553724	62553724	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gatttggacaatcagattaaGaagatgtagctttctgacaa	9	5	2	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr10:62553724G>A	uc001jld.2	+	8	1019	c.885G>A	c.(883-885)AAG>AAA	p.K295K	CDK1_uc001jle.2_RNA|CDK1_uc001jlf.2_Silent_p.K295K|CDK1_uc001jlg.2_Silent_p.K238K	NM_001786	NP_001777	P06493	CDK1_HUMAN	cell division cycle 2 isoform 1	295					activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						ATCAGATTAAGAAGATGTAGC	0.294													0	0	0	0.004482	0	7	34										A	62553724	G	A	62553724	2	1	14	1	0	0	0	0	0	0	0	1	3124	933	33	1		1	CDK1	10	62553724	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	12919635	62553724	72981023	50	3560										
TMEM26	219623	broad.mit.edu	37	chr10	63170341	63170341	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aagaacaccagcatctgattGatcactttgaaataggtcat	7	8	3	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr10:63170341G>A	uc001jlo.2	-	6	1215	c.846C>T	c.(844-846)ATC>ATT	p.I282I	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlp.1_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	282	Helical; (Potential).					integral to membrane					0	Prostate(12;0.0112)					GCATCTGATTGATCACTTTGA	0.507													0	0	0	0.004482	0	7	16										A	63170341	G	A	63170341	2	1	14	1	0	0	0	0	0	0	0	1	16148	1280	45	1		1	TMEM26	10	63170341	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	616617	63170341	72364406	51	3561										
ACTA2	59	broad.mit.edu	37	chr10	90697972	90697972	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcatgatgctgttgtaggtgGtttcatggatgccagcagac	13	7	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr10:90697972G>T	uc001kfp.2	-	8	952	c.836C>A	c.(835-837)ACC>AAC	p.T279N	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.T234N|ACTA2_uc001kfq.2_Missense_Mutation_p.T279N|uc001kfo.1_RNA	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	279					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		GTTGTAGGTGGTTTCATGGAT	0.493													1	0	9.31168e-06	0.016723	9.93246e-06	12	86										T	90697972	G	T	90697972	3	4	14	1	0	0	0	0	1	0	0	0	192	1261	44	4	305	4	ACTA2	10	90697972	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	27527631	90697972	44836775	52	3562										
GANAB	23193	broad.mit.edu	37	chr11	62393546	62393547	+	Nonsense_Mutation	DNP	GG	GG	AA													0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tggtcactcaccttttgtctGgagtaccacagctgctggct							TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:62393546_62393547GG>AA	uc001nub.2	-	23	2748_2749	c.2715_2716CC>TT	c.(2713-2718)CTCCAG>CTTTAG	p.Q906*	GANAB_uc001ntz.2_Nonsense_Mutation_p.Q93*|GANAB_uc001nua.2_Nonsense_Mutation_p.Q928*|GANAB_uc001nuc.2_Nonsense_Mutation_p.Q809*|GANAB_uc010rma.1_Nonsense_Mutation_p.Q814*|GANAB_uc010rmb.1_Nonsense_Mutation_p.Q792*	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	906					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CCTTTTGTCTGGAGTACCACAG	0.554													0	0	0	0.004672	0	11	356										AA	62393547	GG	AA	62393546	4	1	14	1	0	0	0	0	0	1	0	0	6233	1357	47	2	126	2	GANAB	11	62393546	Nonsense_Mutation	DNP	GG	TCGA-BT-A20U-01A-11D-A14W-08		62393546	72612970	53	3563										
ATL3	25923	broad.mit.edu	37	chr11	63403040	63403040	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tggggtgaggcagatcttctCcttgataaattttaatatat	9	5	2	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:63403040C>G	uc001nxk.1	-	10	1277	c.1001G>C	c.(1000-1002)GGA>GCA	p.G334A	ATL3_uc010rms.1_Missense_Mutation_p.G316A|ATL3_uc010rmr.1_5'UTR	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	atlastin 3	334	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			pancreas(1)	1						CAGATCTTCTCCTTGATAAAT	0.303											OREG0021036	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	50										G	63403040	C	G	63403040	3	3	14	1	0	0	0	0	1	0	0	0	1108	855	30	1	640	1	ATL3	11	63403040	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	1009494	63403040	71603476	54	3564										
FRMD8	83786	broad.mit.edu	37	chr11	65161533	65161533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgagcctttcctgcagttccGaaggaacgtgttcttcccaa	9	12	1	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:65161533G>A	uc001odu.3	+	5	569	c.377G>A	c.(376-378)CGA>CAA	p.R126Q	FRMD8_uc009yqj.2_Missense_Mutation_p.R70Q|FRMD8_uc010rof.1_Missense_Mutation_p.R92Q	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	126	FERM.					cytoskeleton	binding			lung(1)|pancreas(1)	2						CTGCAGTTCCGAAGGAACGTG	0.672													0	0	0	0.016723	0	11	30										A	65161533	G	A	65161533	3	1	14	1	0	0	0	0	1	0	0	0	6056	1058	37	1	391	1	FRMD8	11	65161533	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	1758493	65161533	69844983	55	3565										
RNF169	254225	broad.mit.edu	37	chr11	74547657	74547657	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcagcaagaggaagaagaccGacagttggctctgcagttgc	13	9	2	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:74547657G>A	uc001ovl.3	+	6	2022	c.2009G>A	c.(2008-2010)CGA>CAA	p.R670Q	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	670							zinc ion binding			ovary(1)	1						GAAGAAGACCGACAGTTGGCT	0.552													0	0	0	0.016723	0	13	57										A	74547657	G	A	74547657	3	1	14	1	0	0	0	0	1	0	0	0	13460	1058	37	1	2031	1	RNF169	11	74547657	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	9386124	74547657	60458859	56	3566										
C11orf30	56946	broad.mit.edu	37	chr11	76175124	76175124	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	acaaacacaacaacacagaaGgtatgtggtggagggagtct	12	7	1	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:76175124G>A	uc001oxl.2	+	7	974	c.831G>A	c.(829-831)AAG>AAA	p.K277K	C11orf30_uc009yuj.1_Silent_p.K292K|C11orf30_uc010rsa.1_Silent_p.K227K|C11orf30_uc001oxm.2_Silent_p.K278K|C11orf30_uc010rsb.1_Silent_p.K292K|C11orf30_uc010rsc.1_Silent_p.K292K|C11orf30_uc001oxn.2_Silent_p.K278K|C11orf30_uc010rsd.1_Silent_p.K291K	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	277	Interaction with BRCA2.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CAACACAGAAGGTATGTGGTG	0.348													0	0	0	0.008291	0	9	30										A	76175124	G	A	76175124	2	1	14	1	0	0	0	0	0	0	0	1	1636	1014	35	2		2	C11orf30	11	76175124	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	1627467	76175124	58831392	57	3567										
ATM	472	broad.mit.edu	37	chr11	108115627	108115627	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gtgaattaggagatgaaattCttcccactttgctttatatt	7	6	1	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:108115627C>T	uc001pkb.1	+	7	1160	c.775C>T	c.(775-777)CTT>TTT	p.L259F	ATM_uc009yxr.1_Missense_Mutation_p.L259F	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	259					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGATGAAATTCTTCCCACTTT	0.338			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.009096	0	4	67										T	108115627	C	T	108115627	3	4	14	1	0	0	0	0	1	0	0	0	1109	913	32	1	797	1	ATM	11	108115627	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	31940503	108115627	26890889	58	3568										
PKNOX2	63876	broad.mit.edu	37	chr11	125281675	125281675	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcacctccctcctggacaatGaggataagaagtccaagaac	8	12	1	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr11:125281675G>A	uc001qbu.2	+	10	1164	c.850G>A	c.(850-852)GAG>AAG	p.E284K	PKNOX2_uc010saz.1_Missense_Mutation_p.E255K|PKNOX2_uc010sba.1_Missense_Mutation_p.E255K|PKNOX2_uc010sbb.1_Missense_Mutation_p.E220K|PKNOX2_uc001qbv.2_Missense_Mutation_p.E49K	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	284						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CCTGGACAATGAGGATAAGAA	0.527													0	0	0	0.020292	0	15	44										A	125281675	G	A	125281675	3	1	14	1	0	0	0	0	1	0	0	0	11983	1291	45	1	876	1	PKNOX2	11	125281675	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	17166048	125281675	9724841	59	3569										
MRPS35	60488	broad.mit.edu	37	chr12	27877118	27877118	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	agcacgagtagtagtcttaaGagtaagagtttttttcattt	9	4	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr12:27877118G>C	uc001rih.2	+	5	569	c.521G>C	c.(520-522)AGA>ACA	p.R174T	MRPS35_uc001rii.2_Missense_Mutation_p.R174T	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor	174					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					GTAGTCTTAAGAGTAAGAGTT	0.289													0	0	0	0.004482	0	6	31										C	27877118	G	C	27877118	3	2	14	1	0	0	0	0	1	0	0	0	9844	956	33	1	539	1	MRPS35	12	27877118	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		27877118	105974777	60	3570										
IPO8	10526	broad.mit.edu	37	chr12	30814158	30814158	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tactgttttgtcttcaacttCttcatattcatcactttgaa	3	9	6	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr12:30814158C>T	uc001rjd.2	-	16	1968	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	IPO8_uc001rje.1_Missense_Mutation_p.E89K|IPO8_uc010sjt.1_Missense_Mutation_p.E395K	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	600					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TCTTCAACTTCTTCATATTCA	0.338													0	0	0	0.004482	0	9	25										T	30814158	C	T	30814158	3	4	14	1	0	0	0	0	1	0	0	0	7798	922	32	1	1355	1	IPO8	12	30814158	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	2937040	30814158	103037737	61	3571										
IRAK4	51135	broad.mit.edu	37	chr12	44166804	44166804	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ttggtggtaataaaatgggaGagggaggatttggagttgta	17	0	0	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr12:44166804G>C	uc001rnu.3	+	6	710	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	IRAK4_uc001rnt.3_Missense_Mutation_p.E194Q|IRAK4_uc001rnx.3_Missense_Mutation_p.E70Q|IRAK4_uc001rny.3_Missense_Mutation_p.E70Q|IRAK4_uc010sky.1_Missense_Mutation_p.E70Q|IRAK4_uc001rnv.3_Missense_Mutation_p.E70Q|IRAK4_uc001rnw.3_Missense_Mutation_p.E70Q	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	194	ATP (By similarity).|Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		TAAAATGGGAGAGGGAGGATT	0.338													0	0	0	0.006214	0	9	30										C	44166804	G	C	44166804	3	2	14	1	0	0	0	0	1	0	0	0	7825	943	33	1	594	1	IRAK4	12	44166804	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	13352646	44166804	89685091	62	3572										
MYBPC1	4604	broad.mit.edu	37	chr12	102043044	102043044	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ttatcttaattcaggtttaaGaatggtgaagagattatccc	8	5	2	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr12:102043044G>C	uc001tii.2	+	13	1230	c.1128G>C	c.(1126-1128)AAG>AAC	p.K376N	MYBPC1_uc001tif.1_Missense_Mutation_p.K389N|MYBPC1_uc001tig.2_Missense_Mutation_p.K401N|MYBPC1_uc010svq.1_Missense_Mutation_p.K363N|MYBPC1_uc001tih.2_Missense_Mutation_p.K401N|MYBPC1_uc001tij.2_Missense_Mutation_p.K376N|MYBPC1_uc010svr.1_Missense_Mutation_p.K376N|MYBPC1_uc010svs.1_Missense_Mutation_p.K376N|MYBPC1_uc010svt.1_Missense_Mutation_p.K364N|MYBPC1_uc010svu.1_Missense_Mutation_p.K357N|MYBPC1_uc001tik.2_Missense_Mutation_p.K350N	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	376	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TCAGGTTTAAGAATGGTGAAG	0.239													0	0	0	0.006214	0	10	36										C	102043044	G	C	102043044	3	2	14	1	0	0	0	0	1	0	0	0	10011	933	33	1	1261	1	MYBPC1	12	102043044	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	57876240	102043044	31808851	63	3573										
HIP1R	9026	broad.mit.edu	37	chr12	123340550	123340550	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cagcggtacatcgcgcagctGaagagccaggtgaatgcact	13	11	0	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr12:123340550G>A	uc001udj.1	+	14	1211	c.1152G>A	c.(1150-1152)CTG>CTA	p.L384L	HIP1R_uc001udg.1_Silent_p.L372L|HIP1R_uc001udi.1_Silent_p.L384L|HIP1R_uc001udk.1_5'UTR	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	384	Potential.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		TCGCGCAGCTGAAGAGCCAGG	0.692													0	0	0	0.009096	0	4	9										A	123340550	G	A	123340550	2	1	14	1	0	0	0	0	0	0	0	1	7115	1277	45	1		1	HIP1R	12	123340550	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	21297506	123340550	10511345	64	3574										
TUBA3C	7278	broad.mit.edu	37	chr13	19748219	19748219	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tccgcgatggccgtggtgttGctcagcatgcacacagcccg	13	14	1	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr13:19748219G>C	uc009zzj.2	-	5	1186	c.1137C>G	c.(1135-1137)AGC>AGG	p.S379R		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	379					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCGTGGTGTTGCTCAGCATGC	0.622													0	0	0	0.012319	0	20	64										C	19748219	G	C	19748219	3	2	14	1	0	0	0	0	1	0	0	0	16743	1310	46	4	219	4	TUBA3C	13	19748219	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		19748219	95421659	65	3575										
MYH7	4625	broad.mit.edu	37	chr14	23887584	23887584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ggtcgcagtcatgccgggccGactgcagtgcgtgggccagg	18	12	1	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr14:23887584G>A	uc001wjx.2	-	30	4110	c.4004C>T	c.(4003-4005)TCG>TTG	p.S1335L	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ATGCCGGGCCGACTGCAGTGC	0.657													0	0	0	0.003163	0	13	29										A	23887584	G	A	23887584	3	1	14	1	0	0	0	0	1	0	0	0	10039	1059	37	1	1847	1	MYH7	14	23887584	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		23887584	83461956	66	3576										
DAAM1	23002	broad.mit.edu	37	chr14	59819340	59819340	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	aggctgataggttcctttttGagatgagccggtgagtttga	14	5	0	5			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr14:59819340G>C	uc001xdz.1	+	19	2412	c.2287G>C	c.(2287-2289)GAG>CAG	p.E763Q	DAAM1_uc001xea.1_Missense_Mutation_p.E753Q|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	763	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		GTTCCTTTTTGAGATGAGCCG	0.403													0	0	0	0.004482	0	8	18										C	59819340	G	C	59819340	3	2	14	1	0	0	0	0	1	0	0	0	4215	1291	45	1	2357	1	DAAM1	14	59819340	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	35931756	59819340	47530200	67	3577										
NUMB	8650	broad.mit.edu	37	chr14	73743889	73743889	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcctggggctgctgagcccgGacgctcttagacacctcttc	12	15	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr14:73743889G>C	uc001xny.1	-	13	1673	c.1353C>G	c.(1351-1353)GTC>GTG	p.V451V	NUMB_uc010aro.1_Silent_p.V256V|NUMB_uc010arp.1_Silent_p.V245V|NUMB_uc010arq.1_Silent_p.V305V|NUMB_uc010arr.1_Silent_p.V294V|NUMB_uc001xoa.1_Silent_p.V403V|NUMB_uc001xnz.1_Silent_p.V440V|NUMB_uc001xob.1_Silent_p.V392V|NUMB_uc001xod.1_Silent_p.V403V|NUMB_uc001xoc.1_Silent_p.V451V|NUMB_uc010ars.1_Silent_p.V440V|NUMB_uc010ttz.1_Silent_p.V149V|NUMB_uc001xoe.2_RNA	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	451					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		GCTGAGCCCGGACGCTCTTAG	0.607													0	0	0	0.004482	0	8	28										C	73743889	G	C	73743889	2	2	14	1	0	0	0	0	0	0	0	1	10751	1161	41	1		1	NUMB	14	73743889	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	13924549	73743889	33605651	68	3578										
RPAP1	26015	broad.mit.edu	37	chr15	41822071	41822071	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gccctcctcacctcctgtgtCtgctgccgccggacaggggg	13	17	2	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:41822071C>G	uc001zod.2	-	8	1174	c.1050G>C	c.(1048-1050)CAG>CAC	p.Q350H		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	350						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		CCTCCTGTGTCTGCTGCCGCC	0.607													0	0	0	0.001984	0	7	23										G	41822071	C	G	41822071	3	3	14	1	0	0	0	0	1	0	0	0	13541	912	32	1	3203	1	RPAP1	15	41822071	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		41822071	60709321	69	3579			1	12		3	3	1308	C		9.059153e-06
RPAP1	26015	broad.mit.edu	37	chr15	41823249	41823249	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tctggctccagcttgtctctCttcctgggctcactggcaaa	9	14	4	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:41823249C>G	uc001zod.2	-	7	1039	c.915G>C	c.(913-915)AAG>AAC	p.K305N		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	305						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCTTGTCTCTCTTCCTGGGCT	0.557													0	0	0	0.01441	0	51	133										G	41823249	C	G	41823249	3	3	14	1	0	0	0	0	1	0	0	0	13541	912	32	1	3342	1	RPAP1	15	41823249	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	1178	41823249	60708143	70	3580			1	12		3	3	1308	C		9.059153e-06
RPAP1	26015	broad.mit.edu	37	chr15	41823378	41823378	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgcgtgtggctgtgagatctCaagaaagcaaccaagctggg	14	8	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:41823378C>G	uc001zod.2	-	7	910	c.786G>C	c.(784-786)TTG>TTC	p.L262F		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	262						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TGTGAGATCTCAAGAAAGCAA	0.567													0	0	0	0.010771	0	40	163										G	41823378	C	G	41823378	3	3	14	1	0	0	0	0	1	0	0	0	13541	825	29	1	3471	1	RPAP1	15	41823378	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	129	41823378	60708014	71	3581			1	12		3	3	1308	C		9.059153e-06
PYGO1	26108	broad.mit.edu	37	chr15	55839115	55839115	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgtggctggttcctgagtgaGtaaggaccacagtatgggga	16	6	0	2	rs149582531		TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:55839115G>T	uc010bfl.1	-	3	422	c.366C>A	c.(364-366)TAC>TAA	p.Y122*	PYGO1_uc002adf.1_Nonsense_Mutation_p.Y122*	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	122	Pro-rich.				Wnt receptor signaling pathway	nucleus	zinc ion binding			ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		TCCTGAGTGAGTAAGGACCAC	0.473													1	0	6.31663e-08	0.003163	6.9105e-08	16	55										T	55839115	G	T	55839115	4	4	14	1	0	0	0	0	0	1	0	0	12863	1024	36	4	897	4	PYGO1	15	55839115	Nonsense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	14015737	55839115	46692277	72	3582										
HEXA	3073	broad.mit.edu	37	chr15	72645501	72645501	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcggggaaagtcctcaatctCagtcttgttgataaagaact	10	8	3	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:72645501C>T	uc002aun.3	-	5	685	c.478G>A	c.(478-480)GAG>AAG	p.E160K	CELF6_uc002auk.3_Intron|HEXA_uc010ukn.1_Missense_Mutation_p.E171K|HEXA_uc002auo.3_Missense_Mutation_p.E23K|HEXA_uc010bix.2_Missense_Mutation_p.E160K|HEXA_uc010biy.2_Missense_Mutation_p.E23K|HEXA_uc010uko.1_Intron|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	160					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						TCCTCAATCTCAGTCTTGTTG	0.488													0	0	0	0.014758	0	5	19										T	72645501	C	T	72645501	3	4	14	1	0	0	0	0	1	0	0	0	7073	835	29	1	1151	1	HEXA	15	72645501	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	16806386	72645501	29885891	73	3583										
ZNF710	374655	broad.mit.edu	37	chr15	90611183	90611183	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gccacaagaaggcccagctgGatcggctggacatcaacgtg	13	12	1	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:90611183G>C	uc002bov.1	+	2	937	c.814G>C	c.(814-816)GAT>CAT	p.D272H		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GGCCCAGCTGGATCGGCTGGA	0.632													0	0	0	0.010504	0	19	74										C	90611183	G	C	90611183	3	2	14	1	0	0	0	0	1	0	0	0	18112	1174	41	1	816	1	ZNF710	15	90611183	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	17965682	90611183	11920209	74	3584										
C15orf58	390637	broad.mit.edu	37	chr15	90785018	90785018	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcataacttgtttgtcacccGgggagctccgccgggaaaga	12	11	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr15:90785018G>A	uc002bpc.2	+	4	1057	c.878G>A	c.(877-879)CGG>CAG	p.R293Q		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	293					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						TTTGTCACCCGGGGAGCTCCG	0.557													0	0	0	0.008291	0	10	68										A	90785018	G	A	90785018	3	1	14	1	0	0	0	0	1	0	0	0	1806	1116	39	2	880	2	C15orf58	15	90785018	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	173835	90785018	11746374	75	3585										
IGFALS	3483	broad.mit.edu	37	chr16	1841120	1841120	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcgagctccagcagctccgcCagcccccacaggctctgctc	9	20	1	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr16:1841120C>T	uc002cmy.2	-	2	1380	c.1299G>A	c.(1297-1299)CTG>CTA	p.L433L	IGFALS_uc010uvn.1_Silent_p.L471L|IGFALS_uc010uvo.1_Silent_p.L67L	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	433					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						GCAGCTCCGCCAGCCCCCACA	0.682													0	0	0	0.001168	0	6	14										T	1841120	C	T	1841120	2	4	14	1	0	0	0	0	0	0	0	1	7577	581	21	2		2	IGFALS	16	1841120	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		1841120	88513633	76	3586										
SHCBP1	79801	broad.mit.edu	37	chr16	46650007	46650007	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gtgctcacttgagagtcacaGaggtatggttcagcaagcct	12	9	3	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr16:46650007G>A	uc002eec.3	-	4	487	c.447C>T	c.(445-447)CTC>CTT	p.L149L		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	149										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				GAGAGTCACAGAGGTATGGTT	0.468													0	0	0	0.020292	0	13	57										A	46650007	G	A	46650007	2	1	14	1	0	0	0	0	0	0	0	1	14274	929	33	1		1	SHCBP1	16	46650007	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	44808887	46650007	43704746	77	3587										
ZNF276	92822	broad.mit.edu	37	chr16	89788955	89788955	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcaggagcaggccgggctctCgccatgggtcactgtcgcct	15	14	2	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr16:89788955C>T	uc002fos.3	+	2	319	c.222C>T	c.(220-222)CTC>CTT	p.L74L	C16orf7_uc002fol.1_5'Flank|C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_5'UTR|ZNF276_uc002foq.3_5'UTR|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GCCGGGCTCTCGCCATGGGTC	0.662													0	0	0	0.001168	0	6	53										T	89788955	C	T	89788955	2	4	14	1	0	0	0	0	0	0	0	1	17808	871	31	1		1	ZNF276	16	89788955	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	43138948	89788955	565798	78	3588										
ZZEF1	23140	broad.mit.edu	37	chr17	4017635	4017635	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgccatctgactgccagtagGatgaggtttctccatttgtc	10	10	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:4017635G>C	uc002fxe.2	-	4	888	c.824C>G	c.(823-825)TCC>TGC	p.S275C	ZZEF1_uc002fxk.1_Missense_Mutation_p.S275C	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	275	DOC.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTGCCAGTAGGATGAGGTTTC	0.388													0	0	0	0.005524	0	33	88										C	4017635	G	C	4017635	3	2	14	1	0	0	0	0	1	0	0	0	18252	1174	41	1	8269	1	ZZEF1	17	4017635	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		4017635	77177575	79	3589										
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	8	16	1	0	rs121913343		TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.004482	0	8	21										A	7577121	G	A	7577121	3	1	14	1	0	0	0	0	1	0	0	0	16378	1087	38	2	469	2	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	3559486	7577121	73618089	80	3590										
SREBF1	6720	broad.mit.edu	37	chr17	17723649	17723649	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gaggggacaggggtgagggcGctgcctgcggcccgctcagg	21	11	1	1	rs149599437		TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:17723649G>A	uc002gru.1	-	2	472	c.278C>T	c.(277-279)GCG>GTG	p.A93V	SREBF1_uc002grp.1_5'Flank|SREBF1_uc002grq.1_5'UTR|SREBF1_uc002grr.1_5'UTR|SREBF1_uc002grs.1_Missense_Mutation_p.A69V|SREBF1_uc002grt.1_Missense_Mutation_p.A123V|SREBF1_uc010cpp.1_Missense_Mutation_p.A69V|SREBF1_uc010cpq.1_Missense_Mutation_p.A93V	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	93	Pro/Ser-rich.|Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						GGGTGAGGGCGCTGCCTGCGG	0.637													0	0	0	0.00632	0	28	59										A	17723649	G	A	17723649	3	1	14	1	0	0	0	0	1	0	0	0	15140	1087	38	2	3237	2	SREBF1	17	17723649	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	10146528	17723649	63471561	81	3591										
ACACA	31	broad.mit.edu	37	chr17	35445914	35445914	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tagtctctgctgatgcatttGatgttttcctctattaccga	7	9	2	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:35445914G>C	uc002hnm.2	-	55	7067	c.6876C>G	c.(6874-6876)ATC>ATG	p.I2292M	ACACA_uc002hnk.2_Missense_Mutation_p.I2214M|ACACA_uc002hnl.2_Missense_Mutation_p.I2234M|ACACA_uc002hnn.2_Missense_Mutation_p.I2292M|ACACA_uc002hno.2_Missense_Mutation_p.I2329M|ACACA_uc010cuy.2_Missense_Mutation_p.I937M|ACACA_uc010wdb.1_Missense_Mutation_p.I330M|ACACA_uc010wdc.1_Missense_Mutation_p.I418M	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2292					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGATGCATTTGATGTTTTCCT	0.463													0	0	0	0.006214	0	10	221										C	35445914	G	C	35445914	3	2	14	1	0	0	0	0	1	0	0	0	106	1280	45	1	172	1	ACACA	17	35445914	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	17722265	35445914	45749296	82	3592										
C17orf53	78995	broad.mit.edu	37	chr17	42225570	42225570	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gcaagacctcagtcctcagcCttacaccccctactcacctt	4	19	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:42225570C>T	uc002ifi.1	+	3	584	c.399C>T	c.(397-399)GCC>GCT	p.A133A	C17orf53_uc010czq.1_Silent_p.A133A|C17orf53_uc002ifj.1_Silent_p.A133A|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	133											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AGTCCTCAGCCTTACACCCCC	0.517													0	0	0	0.004482	0	7	173										T	42225570	C	T	42225570	2	4	14	1	0	0	0	0	0	0	0	1	1862	668	24	2		2	C17orf53	17	42225570	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	6779656	42225570	38969640	83	3593										
GFAP	2670	broad.mit.edu	37	chr17	42985496	42985496	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgaggtggccttctgacacaGacttggtgtccaggctggtt	14	9	1	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:42985496G>C	uc002ihq.2	-	8	1253	c.1193C>G	c.(1192-1194)TCT>TGT	p.S398C		NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	398	Tail.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				TTCTGACACAGACTTGGTGTC	0.592													0	0	0	0.012213	0	31	75										C	42985496	G	C	42985496	3	2	14	1	0	0	0	0	1	0	0	0	6337	942	33	1	113	1	GFAP	17	42985496	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	759926	42985496	38209714	84	3594										
B4GALNT2	124872	broad.mit.edu	37	chr17	47218697	47218697	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcggaagcatgttccttcaaGcagtgttcagcagccccaag	10	12	2	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:47218697G>A	uc002ion.2	+	2	342	c.283G>A	c.(283-285)GCA>ACA	p.A95T	B4GALNT2_uc010wlt.1_Missense_Mutation_p.A9T|B4GALNT2_uc010wlu.1_Missense_Mutation_p.A35T	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	95	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			GTTCCTTCAAGCAGTGTTCAG	0.507													0	0	0	0.015359	0	34	119										A	47218697	G	A	47218697	3	1	14	1	0	0	0	0	1	0	0	0	1267	971	34	2	307	2	B4GALNT2	17	47218697	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	4233201	47218697	33976513	85	3595										
RPTOR	57521	broad.mit.edu	37	chr17	78936369	78936369	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	atccacccccaggcggacctGatcgcatggtaggcgccacc	11	17	0	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr17:78936369G>C	uc002jyt.1	+	32	4606	c.3801G>C	c.(3799-3801)CTG>CTC	p.L1267L	RPTOR_uc010wug.1_Silent_p.L1109L|RPTOR_uc002jyu.1_Silent_p.L160L	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	1267	WD 6.				cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						AGGCGGACCTGATCGCATGGT	0.642													0	0	0	0.010729	0	11	43										C	78936369	G	C	78936369	2	2	14	1	0	0	0	0	0	0	0	1	13665	1277	45	1		1	RPTOR	17	78936369	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	31717672	78936369	2258841	86	3596										
MYOM1	8736	broad.mit.edu	37	chr18	3090701	3090701	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	atggttagttgcttttccatCttgaagctggaaagtgtacg	11	6	1	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr18:3090701C>G	uc002klp.2	-	27	4298	c.3964G>C	c.(3964-3966)GAT>CAT	p.D1322H	MYOM1_uc002klq.2_Missense_Mutation_p.D1226H	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1322						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCTTTTCCATCTTGAAGCTGG	0.413													0	0	0	0.005443	0	28	61										G	3090701	C	G	3090701	3	3	14	1	0	0	0	0	1	0	0	0	10091	913	32	1	1141	1	MYOM1	18	3090701	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		3090701	74986547	87	3597										
SLC39A3	29985	broad.mit.edu	37	chr19	2737188	2737188	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgatcttcacggggagcaggGagccgagcagcatgaagaag	16	8	2	3			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr19:2737188G>A	uc002lwg.2	-	2	322	c.68C>T	c.(67-69)TCC>TTC	p.S23F	SLC39A3_uc010xgy.1_Missense_Mutation_p.S23F|SLC39A3_uc002lwh.2_Missense_Mutation_p.S23F	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	23	Helical; (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGAGCAGGGAGCCGAGCAG	0.547													0	0	0	0.009096	0	3	22										A	2737188	G	A	2737188	3	1	14	1	0	0	0	0	1	0	0	0	14619	1174	41	1	992	1	SLC39A3	19	2737188	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08		2737188	56391795	88	3598										
MUC16	94025	broad.mit.edu	37	chr19	9048660	9048660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tgccctagaactagcaaccaGagaggtcaccattcctggta	9	12	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr19:9048660G>C	uc002mkp.2	-	5	33175	c.32971C>G	c.(32971-32973)CTG>GTG	p.L10991V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10993	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTAGCAACCAGAGAGGTCACC	0.512													0	0	0	0.001984	0	7	66										C	9048660	G	C	9048660	3	2	14	1	0	0	0	0	1	0	0	0	9973	933	33	1	10872	1	MUC16	19	9048660	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	6311472	9048660	50080323	89	3599										
WIZ	58525	broad.mit.edu	37	chr19	15536463	15536463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cgaaccattgacggaccactCggtcacacccatctgccgca	8	17	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr19:15536463C>T	uc002nbc.2	-	5	1743	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K	WIZ_uc002nba.3_Missense_Mutation_p.E441K|WIZ_uc002nbb.3_Missense_Mutation_p.E400K	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1257						nucleus	zinc ion binding				0						ACGGACCACTCGGTCACACCC	0.612													0	0	0	0.001168	0	6	32										T	15536463	C	T	15536463	3	4	14	1	0	0	0	0	1	0	0	0	17372	893	31	1	1202	1	WIZ	19	15536463	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	6487803	15536463	43592520	90	3600										
KCNN1	3780	broad.mit.edu	37	chr19	18085055	18085055	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tcggcatgtttggcatcgtcGtcatggtgacggagaccgag	15	9	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr19:18085055G>A	uc002nht.2	+	3	668	c.358G>A	c.(358-360)GTC>ATC	p.V120I	KCNN1_uc010xqa.1_Missense_Mutation_p.V120I	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	120	Helical; Name=Segment S1; (Potential).				synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						TGGCATCGTCGTCATGGTGAC	0.642													0	0	0	0.004672	0	3	37										A	18085055	G	A	18085055	3	1	14	1	0	0	0	0	1	0	0	0	8078	1145	40	2	360	2	KCNN1	19	18085055	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	2548592	18085055	41043928	91	3601										
LIPE	3991	broad.mit.edu	37	chr19	42906947	42906947	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tctgtccatggggctcagctCatttttggcctcagcctctt	9	13	5	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr19:42906947C>G	uc002otr.2	-	9	3056	c.2779G>C	c.(2779-2781)GAG>CAG	p.E927Q	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	927					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GGGCTCAGCTCATTTTTGGCC	0.612													0	0	0	0.008291	0	10	38										G	42906947	C	G	42906947	3	3	14	1	0	0	0	0	1	0	0	0	8821	835	29	1	459	1	LIPE	19	42906947	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	24821892	42906947	16222036	92	3602										
ZNF415	55786	broad.mit.edu	37	chr19	53612598	53612598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tccagaatgacttacctgacGtacagtcatgtgtgagccat	9	10	1	4	rs150561707	byFrequency	TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr19:53612598G>A	uc002qax.2	-	7	1193	c.844C>T	c.(844-846)CGT>TGT	p.R282C	ZNF415_uc002qat.2_Missense_Mutation_p.R246C|ZNF415_uc002qaw.2_Missense_Mutation_p.R234C|ZNF415_uc010yds.1_Missense_Mutation_p.R234C|ZNF415_uc010ydt.1_Missense_Mutation_p.R234C|ZNF415_uc002qau.2_Missense_Mutation_p.R221C|ZNF415_uc002qav.2_Missense_Mutation_p.R246C|ZNF415_uc002qba.2_Missense_Mutation_p.R4C|ZNF415_uc002qay.2_Missense_Mutation_p.R221C|ZNF415_uc002qaz.2_Missense_Mutation_p.R282C	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	282	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		CTTACCTGACGTACAGTCATG	0.398													0	0	0	0.007291	0	30	67										A	53612598	G	A	53612598	3	1	14	1	0	0	0	0	1	0	0	0	17889	1145	40	2	971	2	ZNF415	19	53612598	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	10705651	53612598	5516385	93	3603										
SPTLC3	55304	broad.mit.edu	37	chr20	13098330	13098330	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gtgctcatgggcacattcacCaaaagttttggagcttcagg	11	9	3	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr20:13098330C>T	uc002wod.1	+	8	1399	c.1110C>T	c.(1108-1110)ACC>ACT	p.T370T		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	370					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	GCACATTCACCAAAAGTTTTG	0.542													0	0	0	0.013537	0	13	81										T	13098330	C	T	13098330	2	4	14	1	0	0	0	0	0	0	0	1	15124	581	21	2		2	SPTLC3	20	13098330	Silent	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		13098330	49927190	94	3604										
CRNKL1	51340	broad.mit.edu	37	chr20	20024216	20024216	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cctatcaccaaacttcttctCaaagatggtataatttttaa	3	9	3	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr20:20024216C>G	uc002wrs.2	-	8	1407	c.1375G>C	c.(1375-1377)GAG>CAG	p.E459Q		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	459	HAT 7.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						AACTTCTTCTCAAAGATGGTA	0.408													0	0	0	0.014758	0	5	103										G	20024216	C	G	20024216	3	3	14	1	0	0	0	0	1	0	0	0	3891	835	29	1	1203	1	CRNKL1	20	20024216	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08	6925886	20024216	43001304	95	3605										
PRPF6	24148	broad.mit.edu	37	chr20	62657330	62657330	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	gagatctggctggcagccgtGaagctggagtccgagaatga	16	8	1	4			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr20:62657330G>A	uc002yho.2	+	15	2115	c.1947G>A	c.(1945-1947)GTG>GTA	p.V649V	PRPF6_uc002yhp.2_Intron	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	649	HAT 6.				assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TGGCAGCCGTGAAGCTGGAGT	0.652													0	0	0	0.01441	0	62	207										A	62657330	G	A	62657330	2	1	14	1	0	0	0	0	0	0	0	1	12574	1277	45	1		1	PRPF6	20	62657330	Silent	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	42633114	62657330	368190	96	3606										
SFRS15	57466	broad.mit.edu	37	chr21	33076226	33076226	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	catataatcccggaaccttgTattctggtttacactgcaag	7	10	1	0			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chr21:33076226T>A	uc002ypd.2	-	4	599	c.173A>T	c.(172-174)TAC>TTC	p.Y58F	SFRS15_uc002ype.2_Missense_Mutation_p.Y58F|SFRS15_uc010glu.2_Missense_Mutation_p.Y43F|SFRS15_uc002ypf.1_5'Flank|SFRS15_uc002ypg.2_Missense_Mutation_p.Y58F	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	58	CID.					nucleus	nucleotide binding|RNA binding				0						CGGAACCTTGTATTCTGGTTT	0.348													0	0	0	0.004672	0	3	44										A	33076226	T	A	33076226	3	1	14	1	0	0	0	0	1	0	0	0	14171	1638	57	5	3338	5	SFRS15	21	33076226	Missense_Mutation	SNP	T	TCGA-BT-A20U-01A-11D-A14W-08		33076226	15053669	97	3607										
CXorf21	80231	broad.mit.edu	37	chrX	30577604	30577604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	tatactgagaaatatggagaCtaggagtgctaatttcagta	10	4	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chrX:30577604C>T	uc004dcg.1	-	3	1145	c.869G>A	c.(868-870)AGT>AAT	p.S290N		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	290										ovary(1)	1						AATATGGAGACTAGGAGTGCT	0.368													0	0	0	0.013537	0	12	74										T	30577604	C	T	30577604	3	4	14	1	0	0	0	0	1	0	0	0	4101	565	20	2	40	2	CXorf21	23	30577604	Missense_Mutation	SNP	C	TCGA-BT-A20U-01A-11D-A14W-08		30577604	124692956	98	3608										
FGD1	2245	broad.mit.edu	37	chrX	54497828	54497828	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cgggggacctgggtctgagcGaagccgctggggaccttctg	18	11	2	1			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chrX:54497828G>T	uc004dtg.2	-	2	1134	c.400C>A	c.(400-402)CGC>AGC	p.R134S	FGD1_uc011moi.1_5'Flank	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	134	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GGGTCTGAGCGAAGCCGCTGG	0.612													1	0	1.99824e-07	0.00499	2.16758e-07	17	39										T	54497828	G	T	54497828	3	4	14	1	0	0	0	0	1	0	0	0	5832	1058	37	3	2553	3	FGD1	23	54497828	Missense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	23920224	54497828	100772732	99	3609										
KIAA2022	340533	broad.mit.edu	37	chrX	73962899	73962899	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	ttactttttcaccctctagtGagtcaacatcatatagataa	4	9	4	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chrX:73962899G>C	uc004eby.2	-	3	2110	c.1493C>G	c.(1492-1494)TCA>TGA	p.S498*		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	498					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						ACCCTCTAGTGAGTCAACATC	0.438													0	0	0	0.008291	0	11	22										C	73962899	G	C	73962899	4	2	14	1	0	0	0	0	0	1	0	0	8269	1294	45	1	3065	1	KIAA2022	23	73962899	Nonsense_Mutation	SNP	G	TCGA-BT-A20U-01A-11D-A14W-08	19465071	73962899	81307661	100	3610										
ZNF75D	7626	broad.mit.edu	37	chrX	134427903	134427903	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.524752475247525	53	1.71345650616331e-16	3.21672009710853	4.20129270544783	2.54795379710448	0.700465315195843	0.805845052880173	37	cggttgcttcatgataacggAagctccagaagtgcctgcaa	11	10	1	2			TCGA-BT-A20U-01A-11D-A14W-08	TCGA-BT-A20U-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4576527b-b288-4f50-a9ea-5d5dede22561	a8e1dcc1-649d-442a-8663-0ea8ab1ef407	g.chrX:134427903A>T	uc004eyp.2	-	3	2819	c.164T>A	c.(163-165)TTC>TAC	p.F55Y	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'Flank|ZNF75D_uc004eyo.2_Missense_Mutation_p.F55Y	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	55	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ATGATAACGGAAGCTCCAGAA	0.478													0	0	0	0.010818	0	34	82										T	134427903	A	T	134427903	3	4	14	1	0	0	0	0	1	0	0	0	18131	246	9	5	1388	5	ZNF75D	23	134427903	Missense_Mutation	SNP	A	TCGA-BT-A20U-01A-11D-A14W-08	60465004	134427903	20842657	101	3611										
C1orf158	93190	broad.mit.edu	37	chr1	12819342	12819342	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	acaaccggcatggttacaacCcggggctgcctccactccgc	10	17	0	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:12819342C>T	uc001auh.2	+	3	541	c.325C>T	c.(325-327)CCG>TCG	p.P109S	C1orf158_uc010obe.1_Missense_Mutation_p.P109S	NM_152290	NP_689503	Q8N1D5	CA158_HUMAN	hypothetical protein LOC93190	109										ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTTACAACCCGGGGCTGCC	0.537													0	0	0	0.006122	0	17	182										T	12819342	C	T	12819342	3	4	15	1	0	0	0	0	1	0	0	0	2007	623	22	2	335	2	C1orf158	1	12819342	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		12819342	236431279	1	3612										
PTPRU	10076	broad.mit.edu	37	chr1	29651735	29651735	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	acgcagcggcaccttctgcgCctgcgccacggtcctggaga	13	16	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:29651735C>T	uc001bru.2	+	30	4285	c.4175C>T	c.(4174-4176)GCC>GTC	p.A1392V	PTPRU_uc001brv.2_Missense_Mutation_p.A1388V|PTPRU_uc001brw.2_Missense_Mutation_p.A1382V|PTPRU_uc009vtq.2_Missense_Mutation_p.A1386V|PTPRU_uc009vtr.2_Missense_Mutation_p.A1379V|PTPRU_uc001brx.2_Missense_Mutation_p.A118V	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1392	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		ACCTTCTGCGCCTGCGCCACG	0.577													0	0	0	0.010729	0	9	89										T	29651735	C	T	29651735	3	4	15	1	0	0	0	0	1	0	0	0	12813	739	26	2	4315	2	PTPRU	1	29651735	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	16832393	29651735	219598886	2	3613										
IL23R	149233	broad.mit.edu	37	chr1	67666418	67666418	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	catcttttttttttgttttaAgtttagagacagaagaagag	8	3	1	4			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:67666418A>C	uc001ddo.2	+	5	577	c.492_splice	c.e5-2	p.S164_splice	IL23R_uc009waz.2_Intron|IL23R_uc001ddp.2_Splice_Site|IL23R_uc010opi.1_Splice_Site|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Splice_Site_p.S121_splice|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_Splice_Site|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Splice_Site_p.I9_splice|IL23R_uc001ddr.2_Splice_Site|IL23R_uc010opo.1_Splice_Site_p.S23_splice|IL23R_uc010opp.1_Splice_Site|IL23R_uc010opq.1_Splice_Site_p.S23_splice|IL23R_uc010opr.1_Splice_Site|IL23R_uc010ops.1_Intron|IL23R_uc010opt.1_Splice_Site|IL23R_uc010opu.1_Intron|IL23R_uc010opv.1_Splice_Site_p.S23_splice|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_Intron|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_Splice_Site|IL23R_uc010oqb.1_Splice_Site_p.S23_splice|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_Intron|IL23R_uc010oqf.1_Intron|IL23R_uc010oqg.1_Splice_Site|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor						inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						TTTTGTTTTAAGTTTAGAGAC	0.239													0	0	0	0.001168	0	5	75										C	67666418	A	C	67666418	5	2	15	1	0	0	0	0	0	0	1	0	7676	86	3	5	504	5	IL23R	1	67666418	Splice_Site	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	38014683	67666418	181584203	3	3614										
NRAS	4893	broad.mit.edu	37	chr1	115258745	115258745	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cagtgcgcttttcccaacacCacctgctccaaccaccacca	4	20	0	0	rs121434595		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:115258745C>G	uc009wgu.2	-	2	291	c.37G>C	c.(37-39)GGT>CGT	p.G13R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	13	GTP.		G -> D (in a patient with an autoimmune lymphoproliferative disorder).|G -> R (in colorectal cancer).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.G13D(174)|p.G13R(59)|p.G13V(55)|p.G13C(21)|p.G13A(16)|p.G13S(5)|p.G13G(3)|p.G13N(1)|p.G13Y(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCCCAACACCACCTGCTCCA	0.498	G13R(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			0	0	0	0.006214	0	9	97										G	115258745	C	G	115258745	3	3	15	1	0	0	0	0	1	0	0	0	10640	594	21	4	548	4	NRAS	1	115258745	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	47592327	115258745	133991876	4	3615										
RUSC1	23623	broad.mit.edu	37	chr1	155294949	155294949	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tcatctcgcatttcggggccGcccggaacttggtgcagaag	13	12	2	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:155294949G>A	uc001fkj.2	+	4	1742	c.1513G>A	c.(1513-1515)GCC>ACC	p.A505T	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Missense_Mutation_p.A505T|RUSC1_uc009wqn.1_Intron|RUSC1_uc009wqo.1_Missense_Mutation_p.A36T|RUSC1_uc001fkl.2_Missense_Mutation_p.A95T|RUSC1_uc001fkp.2_Missense_Mutation_p.A36T|RUSC1_uc001fkq.2_Missense_Mutation_p.A36T|RUSC1_uc010pgb.1_Missense_Mutation_p.A36T|RUSC1_uc009wqp.1_5'UTR|RUSC1_uc001fkn.2_5'UTR|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Missense_Mutation_p.A36T|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	505						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TTTCGGGGCCGCCCGGAACTT	0.622											OREG0013860	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	19	146										A	155294949	G	A	155294949	3	1	15	1	0	0	0	0	1	0	0	0	13750	1087	38	2	1654	2	RUSC1	1	155294949	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	40036204	155294949	93955672	5	3616										
MPZ	4359	broad.mit.edu	37	chr1	161276712	161276712	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cccttggcatagtggaagatCtatgaggaatgaggggaagc	15	6	1	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:161276712C>A	uc001gaf.3	-	3	302	c.265_splice	c.e3-1	p.I89_splice	MPZ_uc010pko.1_Splice_Site	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero						synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGTGGAAGATCTATGAGGAAT	0.463													1	0	1.836e-18	0.003755	2.13644e-18	37	68										A	161276712	C	A	161276712	5	1	15	1	0	0	0	0	0	0	1	0	9748	927	32	3	528	3	MPZ	1	161276712	Splice_Site	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	5981763	161276712	87973909	6	3617										
EPRS	2058	broad.mit.edu	37	chr1	220195731	220195731	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gatgtggttgaattttgcagCgataaagggttggatctctc	13	5	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr1:220195731C>T	uc001hly.1	-	9	1343	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H	EPRS_uc010puf.1_Missense_Mutation_p.R109H|EPRS_uc001hlz.1_Missense_Mutation_p.R358H|EPRS_uc009xdt.1_Missense_Mutation_p.R159H	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	358	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AATTTTGCAGCGATAAAGGGT	0.383													0	0	0	0.008291	0	11	204										T	220195731	C	T	220195731	3	4	15	1	0	0	0	0	1	0	0	0	5191	768	27	2	3561	2	EPRS	1	220195731	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	58919019	220195731	29054890	7	3618										
RHOB	388	broad.mit.edu	37	chr2	20647511	20647511	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ccggactcgctggagaacatCcccgagaagtgggtccccga	13	14	0	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:20647511C>T	uc002rdv.2	+	1	677	c.285C>T	c.(283-285)ATC>ATT	p.I95I		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	95					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		TGGAGAACATCCCCGAGAAGT	0.617													0	0	0	0.011902	0	43	91										T	20647511	C	T	20647511	2	4	15	1	0	0	0	0	0	0	0	1	13332	845	30	1		1	RHOB	2	20647511	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		20647511	222551862	8	3619										
NRXN1	9378	broad.mit.edu	37	chr2	50724504	50724504	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	caaccacaataaagtcatttCcatccccactgttatataga	3	12	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:50724504C>G	uc010fbq.2	-	14	4443	c.2966G>C	c.(2965-2967)GGA>GCA	p.G989A	NRXN1_uc002rxb.3_Missense_Mutation_p.G621A|NRXN1_uc002rxe.3_Missense_Mutation_p.G949A|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	138	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAGTCATTTCCATCCCCACT	0.353													0	0	0	0.000602	0	5	63										G	50724504	C	G	50724504	3	3	15	1	0	0	0	0	1	0	0	0	10665	855	30	1	1980	1	NRXN1	2	50724504	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	30076993	50724504	192474869	9	3620										
TMEM131	23505	broad.mit.edu	37	chr2	98504542	98504542	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ggaaatccagcattggtggcTcaaatcgtatgggcctgcaa	12	9	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:98504542T>C	uc002syh.3	-	4	561	c.332A>G	c.(331-333)GAG>GGG	p.E111G	TMEM131_uc010yvg.1_RNA	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	111						integral to membrane				ovary(4)|central_nervous_system(2)	6						CATTGGTGGCTCAAATCGTAT	0.333													0	0	0	0.004672	0	3	32										C	98504542	T	C	98504542	3	2	15	1	0	0	0	0	1	0	0	0	16041	1551	54	5	5471	5	TMEM131	2	98504542	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	47780038	98504542	144694831	10	3621										
RAPGEF4	11069	broad.mit.edu	37	chr2	173825863	173825863	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aatccaggtcccttcagagaAgatcctcagagctggaaaaa	9	10	2	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:173825863A>G	uc002uhv.3	+	8	792	c.605A>G	c.(604-606)AAG>AGG	p.K202R	RAPGEF4_uc002uhu.2_Missense_Mutation_p.K202R|RAPGEF4_uc002uhw.3_Missense_Mutation_p.K58R|RAPGEF4_uc010zec.1_Missense_Mutation_p.K49R|RAPGEF4_uc010zed.1_Missense_Mutation_p.K31R|RAPGEF4_uc010zee.1_Missense_Mutation_p.K49R|RAPGEF4_uc010fqo.2_Missense_Mutation_p.K31R|RAPGEF4_uc010zef.1_5'UTR|RAPGEF4_uc010zeg.1_Missense_Mutation_p.K29R|RAPGEF4_uc010fqp.1_5'UTR|RAPGEF4_uc010zeh.1_5'UTR	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	202					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CCTTCAGAGAAGATCCTCAGA	0.413													0	0	0	0.00308	0	8	80										G	173825863	A	G	173825863	3	3	15	1	0	0	0	0	1	0	0	0	13046	72	3	5	651	5	RAPGEF4	2	173825863	Missense_Mutation	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	75321321	173825863	69373510	11	3622										
FKBP7	51661	broad.mit.edu	37	chr2	179343067	179343067	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ataatgggcatttagtaggtCtcccttcttgcttgtcttag	9	8	3	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:179343067C>T	uc002umk.2	-	1	289	c.160G>A	c.(160-162)GAC>AAC	p.D54N	FKBP7_uc002umm.2_Missense_Mutation_p.D54N|FKBP7_uc002uml.2_RNA|FKBP7_uc010zff.1_Missense_Mutation_p.D50N|PLEKHA3_uc002umn.2_5'Flank	NM_181342	NP_851939	Q9Y680	FKBP7_HUMAN	FK506 binding protein 7 isoform a precursor	54	PPIase FKBP-type.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TTTAGTAGGTCTCCCTTCTTG	0.473													0	0	0	0.006214	0	8	78										T	179343067	C	T	179343067	3	4	15	1	0	0	0	0	1	0	0	0	5913	913	32	1	524	1	FKBP7	2	179343067	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	5517204	179343067	63856306	12	3623										
TTN	7273	broad.mit.edu	37	chr2	179462331	179462331	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tttggcaagaagagaatagaCgccttgatggctcctctggc	12	9	1	4			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:179462331C>T	uc010zfg.1	-	243	49998	c.49774G>A	c.(49774-49776)GTC>ATC	p.V16592I	uc002umo.2_RNA|uc002ump.1_RNA|TTN_uc010zfh.1_Missense_Mutation_p.V10287I|TTN_uc010zfi.1_Missense_Mutation_p.V10220I|TTN_uc010zfj.1_Missense_Mutation_p.V10095I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17519							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGAATAGACGCCTTGATGG	0.398													0	0	0	0.004672	0	3	39										T	179462331	C	T	179462331	3	4	15	1	0	0	0	0	1	0	0	0	16732	536	19	2		2	TTN	2	179462331	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	119264	179462331	63737042	13	3624										
ITGA4	3676	broad.mit.edu	37	chr2	182387015	182387015	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gagatgatgcatatgaaacgActctacatgtcaaactaccc	7	10	2	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:182387015A>G	uc002unu.2	+	18	2783	c.2020A>G	c.(2020-2022)ACT>GCT	p.T674A	ITGA4_uc010frj.1_Missense_Mutation_p.T156A|ITGA4_uc002unv.2_5'UTR	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	674	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATATGAAACGACTCTACATGT	0.363													0	0	0	0.009096	0	4	83										G	182387015	A	G	182387015	3	3	15	1	0	0	0	0	1	0	0	0	7878	275	10	5	2090	5	ITGA4	2	182387015	Missense_Mutation	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	2924684	182387015	60812358	14	3625										
DNAJB2	3300	broad.mit.edu	37	chr2	220147644	220147644	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ttctcttcctccttccctggGcactccggtaagttctgccc	7	17	2	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:220147644G>A	uc002vkx.1	+	6	675	c.438G>A	c.(436-438)GGG>GGA	p.G146G	DNAJB2_uc002vkw.1_Silent_p.G146G|DNAJB2_uc002vky.2_5'UTR|DNAJB2_uc010zlb.1_5'UTR	NM_006736	NP_006727	P25686	DNJB2_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 2	146					ER-associated protein catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding|response to unfolded protein	inclusion body	heat shock protein binding|Hsp70 protein binding|polyubiquitin binding|proteasome binding|protein binding|unfolded protein binding				0		Renal(207;0.0474)		Epithelial(149;1.97e-06)|all cancers(144;0.00028)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTTCCCTGGGCACTCCGGTA	0.562													0	0	0	0.009096	0	4	45										A	220147644	G	A	220147644	2	1	15	1	0	0	0	0	0	0	0	1	4620	1190	42	2		2	DNAJB2	2	220147644	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	37760629	220147644	23051729	15	3626										
HTR2B	3357	broad.mit.edu	37	chr2	231978470	231978470	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aattaaccacaccactgtaaTcttgatgaatgctgtagccc	6	11	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:231978470T>G	uc002vro.2	-	3	1031	c.526A>C	c.(526-528)ATT>CTT	p.I176L	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Intron	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	176	Helical; Name=4; (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	ACCACTGTAATCTTGATGAAT	0.428													0	0	0	0.004007	0	14	202										G	231978470	T	G	231978470	3	3	15	1	0	0	0	0	1	0	0	0	7442	1435	50	5	927	5	HTR2B	2	231978470	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	11830826	231978470	11220903	16	3627										
ARL4C	10123	broad.mit.edu	37	chr2	235405159	235405159	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tagagcaccgtggtcttgccGgccgagtccaagcccaacat	11	14	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr2:235405159G>A	uc002vvn.2	-	1	535	c.72C>T	c.(70-72)GCC>GCT	p.A24A	ARL4C_uc002vvm.3_Silent_p.A24A	NM_005737	NP_005728	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	24	GTP (By similarity).				endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			skin(1)	1		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		TGGTCTTGCCGGCCGAGTCCA	0.597													0	0	0	0.004672	0	3	34										A	235405159	G	A	235405159	2	1	15	1	0	0	0	0	0	0	0	1	937	1103	39	2		2	ARL4C	2	235405159	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	3426689	235405159	7794214	17	3628										
SGOL1	151648	broad.mit.edu	37	chr3	20225210	20225210	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	taggatgatatcttgggcttCtttcactttggatttttcat	8	6	4	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:20225210C>G	uc003cbs.2	-	3	416	c.229G>C	c.(229-231)GAA>CAA	p.E77Q	SGOL1_uc003cbr.2_Missense_Mutation_p.E77Q|SGOL1_uc010hfa.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbt.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbu.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbv.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbw.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbx.2_Missense_Mutation_p.E77Q|SGOL1_uc003cby.2_Missense_Mutation_p.E77Q|SGOL1_uc003cbz.2_Missense_Mutation_p.E77Q|SGOL1_uc003cca.2_Missense_Mutation_p.E77Q|SGOL1_uc003ccb.2_Missense_Mutation_p.E77Q|SGOL1_uc003ccc.2_Missense_Mutation_p.E77Q	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	77	Potential.|Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						TCTTGGGCTTCTTTCACTTTG	0.338													0	0	0	0.001855	0	14	105										G	20225210	C	G	20225210	3	3	15	1	0	0	0	0	1	0	0	0	14216	922	32	1	1504	1	SGOL1	3	20225210	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		20225210	177797220	18	3629										
SCN11A	11280	broad.mit.edu	37	chr3	38945514	38945514	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cttcttaacgcacagccactGggggcaacagttccacacga	9	14	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:38945514G>T	uc011ays.1	-	12	1883	c.1684C>A	c.(1684-1686)CAG>AAG	p.Q562K		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	562					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CACAGCCACTGGGGGCAACAG	0.502													1	0	0.00024832	0.009096	0.000264875	4	72										T	38945514	G	T	38945514	3	4	15	1	0	0	0	0	1	0	0	0	13913	1357	47	4	3751	4	SCN11A	3	38945514	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	18720304	38945514	159076916	19	3630										
NKTR	4820	broad.mit.edu	37	chr3	42680096	42680096	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tgaggggtcctgttccaattCggaaaacaataggggaaagc	13	7	0	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:42680096C>T	uc003clo.2	+	13	3047	c.2900C>T	c.(2899-2901)TCG>TTG	p.S967L	NKTR_uc003clm.1_Missense_Mutation_p.S714L|NKTR_uc003clp.2_Missense_Mutation_p.S714L|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.S857L|NKTR_uc003clr.1_Missense_Mutation_p.S714L|NKTR_uc003cls.2_Missense_Mutation_p.S667L	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	967					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TGTTCCAATTCGGAAAACAAT	0.408													0	0	0	0.000602	0	5	70										T	42680096	C	T	42680096	3	4	15	1	0	0	0	0	1	0	0	0	10448	893	31	1	2946	1	NKTR	3	42680096	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	3734582	42680096	155342334	20	3631										
ROBO1	6091	broad.mit.edu	37	chr3	78685192	78685192	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ccacatcaccataaacagttGactcagggagcatcagattt	7	11	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:78685192G>C	uc003dqe.2	-	23	3312	c.3104C>G	c.(3103-3105)TCA>TGA	p.S1035*	ROBO1_uc003dqb.2_Nonsense_Mutation_p.S996*|ROBO1_uc003dqc.2_Intron|ROBO1_uc003dqd.2_Nonsense_Mutation_p.S990*|ROBO1_uc010hoh.2_Nonsense_Mutation_p.S227*|ROBO1_uc011bgl.1_Nonsense_Mutation_p.S607*	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1035	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ATAAACAGTTGACTCAGGGAG	0.378													0	0	0	0.009096	0	4	41										C	78685192	G	C	78685192	4	2	15	1	0	0	0	0	0	1	0	0	13513	1294	45	1	1887	1	ROBO1	3	78685192	Nonsense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	36005096	78685192	119337238	21	3632										
IMPG2	50939	broad.mit.edu	37	chr3	100948226	100948226	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aaatgcaaagtttcccacctCtctggaaagctcactgctct	6	13	3	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:100948226C>G	uc003duq.1	-	17	3834	c.3631G>C	c.(3631-3633)GAG>CAG	p.E1211Q	IMPG2_uc011bhe.1_Missense_Mutation_p.E1074Q|IMPG2_uc010hpj.1_RNA	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1211	Cytoplasmic (Potential).|Hyaluronan-binding motif involved in chondroitin sulfate A- and C-binding motif (By similarity).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTTCCCACCTCTCTGGAAAGC	0.532													0	0	0	0.004482	0	7	38										G	100948226	C	G	100948226	3	3	15	1	0	0	0	0	1	0	0	0	7729	922	32	1	106	1	IMPG2	3	100948226	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	22263034	100948226	97074204	22	3633										
FBXO40	51725	broad.mit.edu	37	chr3	121341105	121341105	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aggaaaatcagaagcagcagGacgttcgtacagccatggaa	12	8	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:121341105G>A	uc003eeg.2	+	3	1039	c.829G>A	c.(829-831)GAC>AAC	p.D277N		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	277					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		GAAGCAGCAGGACGTTCGTAC	0.483													0	0	0	0.001984	0	6	42										A	121341105	G	A	121341105	3	1	15	1	0	0	0	0	1	0	0	0	5749	1174	41	1	835	1	FBXO40	3	121341105	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	20392879	121341105	76681325	23	3634										
TRIM42	287015	broad.mit.edu	37	chr3	140397214	140397214	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ctgcccttacaaagatgagcGgaactgccagttctgccact	9	13	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:140397214G>A	uc003eto.1	+	1	334	c.143G>A	c.(142-144)CGG>CAG	p.R48Q		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	48	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						AAAGATGAGCGGAACTGCCAG	0.537													0	0	0	0.008291	0	10	158										A	140397214	G	A	140397214	3	1	15	1	0	0	0	0	1	0	0	0	16514	1116	39	2	145	2	TRIM42	3	140397214	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	19056109	140397214	57625216	24	3635										
SMC4	10051	broad.mit.edu	37	chr3	160146645	160146645	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ataaactcaaggcccaacaaGacaaacttgataaaataaat	4	8	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr3:160146645G>C	uc003fdh.2	+	18	2823	c.2710G>C	c.(2710-2712)GAC>CAC	p.D904H	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.D879H|SMC4_uc003fdj.2_Missense_Mutation_p.D904H|SMC4_uc010hwd.2_Missense_Mutation_p.D904H|SMC4_uc003fdl.2_Missense_Mutation_p.D607H	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	904	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGCCCAACAAGACAAACTTGA	0.378													0	0	0	0.001984	0	6	90										C	160146645	G	C	160146645	3	2	15	1	0	0	0	0	1	0	0	0	14785	942	33	1	2776	1	SMC4	3	160146645	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	19749431	160146645	37875785	25	3636										
C4orf35	85438	broad.mit.edu	37	chr4	71200994	71200994	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aaaaactcaaatcagaagatGatatggggaccgactttatt	8	6	2	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr4:71200994G>C	uc003hff.2	+	1	324	c.238G>C	c.(238-240)GAT>CAT	p.D80H		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	80						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				ATCAGAAGATGATATGGGGAC	0.373													0	0	0	0.000602	0	5	71										C	71200994	G	C	71200994	3	2	15	1	0	0	0	0	1	0	0	0	2265	1290	45	1	240	1	C4orf35	4	71200994	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08		71200994	119953282	26	3637										
MMRN1	22915	broad.mit.edu	37	chr4	90872768	90872768	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cgtaacagaggagtattcaaGctgtagtcggcatccgtgcc	12	10	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr4:90872768G>T	uc003hst.2	+	7	3202	c.3131G>T	c.(3130-3132)AGC>ATC	p.S1044I	MMRN1_uc010iku.2_Missense_Mutation_p.S347I|MMRN1_uc011cds.1_Missense_Mutation_p.S786I	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1044	EGF-like.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		GAGTATTCAAGCTGTAGTCGG	0.383													1	0	3.59834e-05	0.001168	3.93664e-05	5	53										T	90872768	G	T	90872768	3	4	15	1	0	0	0	0	1	0	0	0	9670	971	34	4	3157	4	MMRN1	4	90872768	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	19671774	90872768	100281508	27	3638										
KIAA1109	84162	broad.mit.edu	37	chr4	123160717	123160717	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gccctgtgtctcctaatactCaggataagtcagtaggtcaa	9	10	4	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr4:123160717C>G	uc003ieh.2	+	27	3925	c.3880C>G	c.(3880-3882)CAG>GAG	p.Q1294E	KIAA1109_uc003iei.1_Missense_Mutation_p.Q1047E|KIAA1109_uc010ins.1_Missense_Mutation_p.Q637E|KIAA1109_uc003iek.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1294					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCCTAATACTCAGGATAAGTC	0.403													0	0	0	0.00278	0	22	40										G	123160717	C	G	123160717	3	3	15	1	0	0	0	0	1	0	0	0	8208	827	29	1	3986	1	KIAA1109	4	123160717	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	32287949	123160717	67993559	28	3639										
SEMA5A	9037	broad.mit.edu	37	chr5	9122934	9122934	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cacaccaaagtgcccatccaCggtgagattcctggtctagg	10	13	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:9122934C>T	uc003jek.2	-	14	2327	c.1615G>A	c.(1615-1617)GTG>ATG	p.V539M		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	539	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGCCCATCCACGGTGAGATTC	0.517													0	0	0	0.01441	0	66	59										T	9122934	C	T	9122934	3	4	15	1	0	0	0	0	1	0	0	0	14037	536	19	2	1649	2	SEMA5A	5	9122934	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		9122934	171792326	29	3640										
DNAH5	1767	broad.mit.edu	37	chr5	13753535	13753535	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	acatctcactgagatttaggTtctttccaaatggaattttc	6	8	2	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:13753535T>A	uc003jfd.2	-	63	10721	c.10679A>T	c.(10678-10680)AAC>ATC	p.N3560I	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3560					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAGATTTAGGTTCTTTCCAAA	0.378									Kartagener_syndrome				0	0	0	0.006214	0	10	241										A	13753535	T	A	13753535	3	1	15	1	0	0	0	0	1	0	0	0	4604	1725	60	5	3263	5	DNAH5	5	13753535	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	4630601	13753535	167161725	30	3641										
DNAH5	1767	broad.mit.edu	37	chr5	13823473	13823473	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	caaaaacaagggttcatcctCatcaatctaaaaaaagaaaa	4	8	4	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:13823473C>T	uc003jfd.2	-	40	6628	c.6586G>A	c.(6586-6588)GAG>AAG	p.E2196K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2196					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGTTCATCCTCATCAATCTAA	0.368									Kartagener_syndrome				0	0	0	0.008291	0	11	156										T	13823473	C	T	13823473	3	4	15	1	0	0	0	0	1	0	0	0	4604	835	29	1	7448	1	DNAH5	5	13823473	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	69938	13823473	167091787	31	3642										
CHSY3	337876	broad.mit.edu	37	chr5	129520760	129520760	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gagattcatggagaactttgAaaacatgtgtcttatcccaa	8	7	2	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:129520760A>G	uc003kvd.2	+	3	1925	c.1925A>G	c.(1924-1926)GAA>GGA	p.E642G		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	642	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GAGAACTTTGAAAACATGTGT	0.403													0	0	0	0.001168	0	4	69										G	129520760	A	G	129520760	3	3	15	1	0	0	0	0	1	0	0	0	3413	246	9	5	1935	5	CHSY3	5	129520760	Missense_Mutation	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	115697287	129520760	51394500	32	3643										
REEP2	51308	broad.mit.edu	37	chr5	137780945	137780945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ggtgctgtcagagaagctccGcagcttcagcatgcaggacc	13	12	2	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:137780945G>A	uc003lcz.2	+	6	562	c.440G>A	c.(439-441)CGC>CAC	p.R147H	REEP2_uc003lda.2_Missense_Mutation_p.R149H|REEP2_uc011cyt.1_Missense_Mutation_p.R108H	NM_016606	NP_057690	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	147						integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GAGAAGCTCCGCAGCTTCAGC	0.692													0	0	0	0.000602	0	5	56										A	137780945	G	A	137780945	3	1	15	1	0	0	0	0	1	0	0	0	13205	1087	38	2	462	2	REEP2	5	137780945	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	8260185	137780945	43134315	33	3644										
PCDHGB2	56103	broad.mit.edu	37	chr5	140741601	140741601	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cgcacagcgcgtgccttgggCgacagggacgcggcccgcca	16	16	0	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:140741601C>T	uc003ljs.1	+	1	1899	c.1899C>T	c.(1897-1899)GGC>GGT	p.G633G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Silent_p.G633G|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	633	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCTTGGGCGACAGGGACG	0.687													0	0	0	0.003163	0	10	16										T	140741601	C	T	140741601	2	4	15	1	0	0	0	0	0	0	0	1	11563	755	27	2		2	PCDHGB2	5	140741601	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	2960656	140741601	40173659	34	3645										
FLT4	2324	broad.mit.edu	37	chr5	180057288	180057288	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ggcacccacatggcgtccttCctgttgaccaagagcgtgtc	11	14	0	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr5:180057288C>T	uc003mma.3	-	4	529	c.450G>A	c.(448-450)AGG>AGA	p.R150R	FLT4_uc003mlz.3_Silent_p.R150R|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.1_Silent_p.R150R|FLT4_uc011dgz.1_Silent_p.R150R|FLT4_uc011dha.1_Missense_Mutation_p.G134E	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	150	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGGCGTCCTTCCTGTTGACCA	0.632									Congenital_Hereditary_Lymphedema				0	0	0	0.004007	0	14	30										T	180057288	C	T	180057288	2	4	15	1	0	0	0	0	0	0	0	1	5944	854	30	1		1	FLT4	5	180057288	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	39315687	180057288	857972	35	3646										
TUBB	203068	broad.mit.edu	37	chr6	30691914	30691914	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ccgtctgtgacatcccacctCgtggcctcaagatggcagtc	10	15	2	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:30691914C>T	uc003nrl.2	+	4	1202	c.1075C>T	c.(1075-1077)CGT>TGT	p.R359C	TUBB_uc003nrk.1_Missense_Mutation_p.R359C|TUBB_uc011dmq.1_Missense_Mutation_p.R287C	NM_178014	NP_821133	P07437	TBB5_HUMAN	tubulin, beta	359					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			ovary(1)	1					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	CATCCCACCTCGTGGCCTCAA	0.532													0	0	0	0.00333	0	20	67										T	30691914	C	T	30691914	3	4	15	1	0	0	0	0	1	0	0	0	16749	884	31	1	1089	1	TUBB	6	30691914	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		30691914	140423153	36	3647										
ASCC3	10973	broad.mit.edu	37	chr6	100966000	100966000	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	caccagccagccctggtttgCagccacgtccagcattgcct	9	17	0	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:100966000C>T	uc003pqk.2	-	38	6123	c.5794G>A	c.(5794-5796)GCA>ACA	p.A1932T		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1932	SEC63 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CCCTGGTTTGCAGCCACGTCC	0.478													0	0	0	0.000602	0	4	43										T	100966000	C	T	100966000	3	4	15	1	0	0	0	0	1	0	0	0	1033	710	25	2	834	2	ASCC3	6	100966000	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	70274086	100966000	70149067	37	3648										
SEC63	11231	broad.mit.edu	37	chr6	108193031	108193031	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gggtgattttctggcacaggCttagcctcatgaacttccaa	10	10	2	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:108193031C>T	uc003psc.3	-	21	2429	c.2160G>A	c.(2158-2160)AAG>AAA	p.K720K	SEC63_uc003psb.3_Silent_p.K547K	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	720	Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CTGGCACAGGCTTAGCCTCAT	0.418													0	0	0	0.004482	0	8	93										T	108193031	C	T	108193031	2	4	15	1	0	0	0	0	0	0	0	1	14005	796	28	2		2	SEC63	6	108193031	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	7227031	108193031	62922036	38	3649										
IYD	389434	broad.mit.edu	37	chr6	150713566	150713566	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aagcacaagattcgaaagatCattgaggaggaagaggagat	13	4	1	5			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:150713566C>G	uc003qnu.1	+	3	596	c.456C>G	c.(454-456)ATC>ATG	p.I152M	IYD_uc003qnv.1_Missense_Mutation_p.I152M|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Missense_Mutation_p.I152M|IYD_uc010kik.1_Missense_Mutation_p.I70M	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	152	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		TTCGAAAGATCATTGAGGAGG	0.522													0	0	0	0.00308	0	8	65										G	150713566	C	G	150713566	3	3	15	1	0	0	0	0	1	0	0	0	7932	816	29	1	466	1	IYD	6	150713566	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	42520535	150713566	20401501	39	3650										
QKI	9444	broad.mit.edu	37	chr6	163984654	163984654	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gcaatagttcctccagggccCgaagctggtttaatctatac	9	11	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr6:163984654C>T	uc003qui.2	+	6	1388	c.837C>T	c.(835-837)CCC>CCT	p.P279P	QKI_uc003que.2_Silent_p.P279P|QKI_uc003quf.2_Silent_p.P279P|QKI_uc003qug.2_Silent_p.P279P|QKI_uc003quh.2_Silent_p.P271P|QKI_uc003quj.2_Silent_p.P271P	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	279	SH3-binding.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		CTCCAGGGCCCGAAGCTGGTT	0.478													0	0	0	0.00245	0	15	64										T	163984654	C	T	163984654	2	4	15	1	0	0	0	0	0	0	0	1	12873	639	23	2		2	QKI	6	163984654	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	13271088	163984654	7130413	40	3651										
FAM126A	84668	broad.mit.edu	37	chr7	23016375	23016375	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tgtataccacttttgacaaaCcatgctgggatagtgcactc	8	10	0	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr7:23016375C>A	uc003svm.3	-	6	722	c.467G>T	c.(466-468)GGT>GTT	p.G156V	FAM126A_uc003svn.3_Missense_Mutation_p.G12V|FAM126A_uc011jyr.1_Missense_Mutation_p.G122V	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	156						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						TTTTGACAAACCATGCTGGGA	0.418													1	0	2.0095e-06	0.001984	2.23666e-06	6	73										A	23016375	C	A	23016375	3	1	15	1	0	0	0	0	1	0	0	0	5429	507	18	4	1122	4	FAM126A	7	23016375	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		23016375	136122288	41	3652										
AKAP9	10142	broad.mit.edu	37	chr7	91726612	91726613	+	Frame_Shift_Ins	INS	-	-	A													0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gcaggaattccagaagcaagINSaactagaacgagaagaaaaa							TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr7:91726612_91726613insA	uc003ulg.2	+	41	10564_10565	c.10339_10340insA	c.(10339-10341)GAAfs	p.E3447fs	AKAP9_uc003ulf.2_Frame_Shift_Ins_p.E3439fs|AKAP9_uc003uli.2_Frame_Shift_Ins_p.E3070fs|AKAP9_uc003ulj.2_Frame_Shift_Ins_p.E1217fs|AKAP9_uc003ull.2_Frame_Shift_Ins_p.E343fs	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3451	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CCAGAAGCAAGAACTAGAACGA	0.376			T	BRAF	papillary thyroid													19	23	---	---								A	91726613	-	A	91726612	7	5	15	1	0	1	1	0	0	0	0	0	459	943	33	0	10501	0	AKAP9	7	91726612	Frame_Shift_Ins	INS	-	TCGA-BT-A20W-01A-21D-A14W-08	68710237	91726612	67412051	42	3653										
CPA2	1358	broad.mit.edu	37	chr7	129908841	129908841	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ctacaattggaggctcaagaAcatctccaggtatttgatct	8	9	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr7:129908841A>G	uc003vpq.2	+	2	163	c.144A>G	c.(142-144)GAA>GAG	p.E48E	CPA2_uc011kpc.1_Silent_p.E48E	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	48					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AGGCTCAAGAACATCTCCAGG	0.373													0	0	0	0.009096	0	4	62										G	129908841	A	G	129908841	2	3	15	1	0	0	0	0	0	0	0	1	3790	40	2	5		5	CPA2	7	129908841	Silent	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	38182229	129908841	29229822	43	3654										
SGK223	157285	broad.mit.edu	37	chr8	8185379	8185379	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tttttctggccgcccatgaaGaggtcctcacatttggctac	9	12	2	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:8185379G>A	uc003wsh.3	-	4	2913	c.2913C>T	c.(2911-2913)CTC>CTT	p.L971L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	971							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CGCCCATGAAGAGGTCCTCAC	0.562													0	0	0	0.00308	0	6	37										A	8185379	G	A	8185379	2	1	15	1	0	0	0	0	0	0	0	1	14210	929	33	1		1	SGK223	8	8185379	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08		8185379	138178643	44	3655										
FBXO16	157574	broad.mit.edu	37	chr8	28304779	28304779	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	agtctggggtcatttggtttCtttttcttcttctgtaaatt	8	6	6	0	rs149234031	byFrequency	TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:28304779C>G	uc003xgu.2	-	7	850	c.752G>C	c.(751-753)AGA>ACA	p.R251T	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.R238T|FBXO16_uc003xgw.2_Missense_Mutation_p.R238T	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	251										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		CATTTGGTTTCTTTTTCTTCT	0.353													0	0	0	0.008361	0	29	79										G	28304779	C	G	28304779	3	3	15	1	0	0	0	0	1	0	0	0	5729	913	32	1	138	1	FBXO16	8	28304779	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	20119400	28304779	118059243	45	3656										
ADHFE1	137872	broad.mit.edu	37	chr8	67357557	67357557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	taaggctgctaatctgtatgCatccagccctcattctgatt	7	11	3	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:67357557C>T	uc003xwb.3	+	6	492	c.458C>T	c.(457-459)GCA>GTA	p.A153V	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.A105V|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Missense_Mutation_p.A83V|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	153					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			AATCTGTATGCATCCAGCCCT	0.488													0	0	0	0.008291	0	10	142										T	67357557	C	T	67357557	3	4	15	1	0	0	0	0	1	0	0	0	314	710	25	2	480	2	ADHFE1	8	67357557	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	39052778	67357557	79006465	46	3657										
VPS13B	157680	broad.mit.edu	37	chr8	100844794	100844794	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gacagctcacagtgctggagCctgccagctatagttagacc	11	12	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:100844794C>G	uc003yiv.2	+	52	9714	c.9603C>G	c.(9601-9603)AGC>AGG	p.S3201R	VPS13B_uc003yiw.2_Missense_Mutation_p.S3176R	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3201					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGTGCTGGAGCCTGCCAGCTA	0.502													0	0	0	0.001168	0	5	94										G	100844794	C	G	100844794	3	3	15	1	0	0	0	0	1	0	0	0	17187	738	26	4	9999	4	VPS13B	8	100844794	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	33487237	100844794	45519228	47	3658										
LRRC6	23639	broad.mit.edu	37	chr8	133584686	133584686	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ttagtcacatcagggaatgaGtgcttgctagggtctacttc	11	8	3	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:133584686G>T	uc003ytk.2	-	12	1343	c.1269C>A	c.(1267-1269)CAC>CAA	p.H423Q	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	423						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGGGAATGAGTGCTTGCTAG	0.378													1	0	0.00307968	0.00308	0.00320487	8	208										T	133584686	G	T	133584686	3	4	15	1	0	0	0	0	1	0	0	0	9016	1020	36	4	135	4	LRRC6	8	133584686	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	32739892	133584686	12779336	48	3659										
ZFAT	57623	broad.mit.edu	37	chr8	135615035	135615035	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	acattgaggttggccttgatGgcactggcatagctgcactg	13	9	0	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr8:135615035G>T	uc003yup.2	-	6	1102	c.927C>A	c.(925-927)GCC>GCA	p.A309A	ZFAT_uc003yun.2_Silent_p.A297A|ZFAT_uc003yuo.2_Silent_p.A297A|ZFAT_uc010meh.2_Silent_p.A297A|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.A297A|ZFAT_uc010mej.2_Silent_p.A247A|ZFAT_uc003yur.2_Silent_p.A297A	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	309	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGGCCTTGATGGCACTGGCAT	0.562													1	0	0.000602214	0.000602	0.000631832	5	49										T	135615035	G	T	135615035	2	4	15	1	0	0	0	0	0	0	0	1	17629	1335	47	4		4	ZFAT	8	135615035	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	2030349	135615035	10748987	49	3660										
MPDZ	8777	broad.mit.edu	37	chr9	13162702	13162702	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tcacttacctgccagtgtatGaagaaaaaatatccagtgcc	7	10	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:13162702G>A	uc010mia.1	-	22	3404	c.3347C>T	c.(3346-3348)TCA>TTA	p.S1116L	MPDZ_uc010mhx.2_Missense_Mutation_p.S8L|MPDZ_uc011lmm.1_Missense_Mutation_p.S8L|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.S1116L|MPDZ_uc010mhz.2_Missense_Mutation_p.S1116L|MPDZ_uc011lmn.1_Missense_Mutation_p.S1116L|MPDZ_uc003zlb.3_Missense_Mutation_p.S1116L	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1116					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		GCCAGTGTATGAAGAAAAAAT	0.378													0	0	0	0.006122	0	18	6										A	13162702	G	A	13162702	3	1	15	1	0	0	0	0	1	0	0	0	9722	1294	45	1	2874	1	MPDZ	9	13162702	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08		13162702	128050729	50	3661										
RNF20	56254	broad.mit.edu	37	chr9	104314697	104314697	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	agtggtagtgccctcctgcaGtcccagtctagtactgagga	12	11	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:104314697G>A	uc004bbn.2	+	13	1653	c.1563G>A	c.(1561-1563)CAG>CAA	p.Q521Q		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	521	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		CCCTCCTGCAGTCCCAGTCTA	0.498													0	0	0	0.006214	0	9	234										A	104314697	G	A	104314697	2	1	15	1	0	0	0	0	0	0	0	1	13473	1020	36	2		2	RNF20	9	104314697	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	91151995	104314697	36898734	51	3662										
KIAA0368	23392	broad.mit.edu	37	chr9	114176711	114176711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cgcgtcacatattcctacctCcaacacctgctaacagctgc	5	17	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:114176711C>T	uc004bfe.1	-	20	2519	c.2519G>A	c.(2518-2520)GGA>GAA	p.G840E	KIAA0368_uc010muc.1_Missense_Mutation_p.G662E	NM_001080398	NP_001073867			KIAA0368 protein												0						ATTCCTACCTCCAACACCTGC	0.413													0	0	0	0.00308	0	7	64										T	114176711	C	T	114176711	3	4	15	1	0	0	0	0	1	0	0	0	8171	855	30	1	3662	1	KIAA0368	9	114176711	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	9862014	114176711	27036720	52	3663										
NUP188	23511	broad.mit.edu	37	chr9	131755675	131755675	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	agttaaggatggcagtgatgGctcaaaggtaagcctgtaac	13	6	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:131755675G>C	uc004bws.1	+	26	2862	c.2840G>C	c.(2839-2841)GGC>GCC	p.G947A	NUP188_uc004bwu.2_Missense_Mutation_p.G290A	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	947					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GGCAGTGATGGCTCAAAGGTA	0.522													0	0	0	0.004672	0	3	42										C	131755675	G	C	131755675	3	2	15	1	0	0	0	0	1	0	0	0	10758	1203	42	4	2942	4	NUP188	9	131755675	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	17578964	131755675	9457756	53	3664										
POMT1	10585	broad.mit.edu	37	chr9	134381814	134381814	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tttaggaggattcgatggcaAttttttgtggaacagaattg	12	3	0	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:134381814A>G	uc004cav.2	+	4	456	c.254A>G	c.(253-255)AAT>AGT	p.N85S	POMT1_uc011mci.1_Missense_Mutation_p.N85S|POMT1_uc004cax.2_Missense_Mutation_p.N85S|POMT1_uc011mcj.1_Missense_Mutation_p.I3V|POMT1_uc004cau.2_Missense_Mutation_p.N85S|POMT1_uc004caw.2_Missense_Mutation_p.N31S|POMT1_uc011mck.1_5'UTR|POMT1_uc011mcl.1_5'UTR|POMT1_uc011mcm.1_Silent_p.Q49Q	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	85	Helical; (Potential).				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TTCGATGGCAATTTTTTGTGG	0.264													0	0	0	0.001855	0	10	238										G	134381814	A	G	134381814	3	3	15	1	0	0	0	0	1	0	0	0	12245	101	4	5	264	5	POMT1	9	134381814	Missense_Mutation	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	2626139	134381814	6831617	54	3665										
TTF1	7270	broad.mit.edu	37	chr9	135276961	135276961	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tctactgaatcaaagagtgtGctctcagagttcttactggg	10	8	4	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:135276961G>A	uc004cbl.2	-	2	1300	c.1248C>T	c.(1246-1248)AGC>AGT	p.S416S	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	416					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CAAAGAGTGTGCTCTCAGAGT	0.463													0	0	0	0.001168	0	5	88										A	135276961	G	A	135276961	2	1	15	1	0	0	0	0	0	0	0	1	16715	1310	46	2		2	TTF1	9	135276961	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	895147	135276961	5936470	55	3666										
COL5A1	1289	broad.mit.edu	37	chr9	137619185	137619185	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ctgtgagcactacagccctgActgtgacaccgcagtacctg	10	14	0	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:137619185A>T	uc004cfe.2	+	5	1110	c.728A>T	c.(727-729)GAC>GTC	p.D243V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	243	Nonhelical region.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TACAGCCCTGACTGTGACACC	0.532													0	0	0	0.001984	0	7	68										T	137619185	A	T	137619185	3	4	15	1	0	0	0	0	1	0	0	0	3696	275	10	5	746	5	COL5A1	9	137619185	Missense_Mutation	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	2342224	137619185	3594246	56	3667										
FBXW5	54461	broad.mit.edu	37	chr9	139837920	139837920	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ctccacgcagggcaccgtgtCatacagccgctggaactcct	10	16	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr9:139837920C>A	uc004cjx.2	-	3	383	c.232G>T	c.(232-234)GAC>TAC	p.D78Y	FBXW5_uc010nbx.2_5'Flank|FBXW5_uc004cjy.2_5'UTR|FBXW5_uc004cjz.2_5'UTR|C8G_uc004cka.2_5'Flank	NM_018998	NP_061871	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	78							catalytic activity|protein binding				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		GGCACCGTGTCATACAGCCGC	0.657													1	0	3.07112e-06	0.010729	3.38882e-06	10	16										A	139837920	C	A	139837920	3	1	15	1	0	0	0	0	1	0	0	0	5768	826	29	3	1496	3	FBXW5	9	139837920	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	2218735	139837920	1375511	57	3668										
CUL2	8453	broad.mit.edu	37	chr10	35360158	35360158	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	attccatgttgctctttcgaCgtattccaacatgaccacgg	7	12	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:35360158C>T	uc001ixv.2	-	2	298	c.88G>A	c.(88-90)GTC>ATC	p.V30I	CUL2_uc009xma.2_5'UTR|CUL2_uc010qer.1_Missense_Mutation_p.V49I|CUL2_uc001ixw.2_Missense_Mutation_p.V30I|CUL2_uc010qes.1_Missense_Mutation_p.V30I	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	30					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						GCTCTTTCGACGTATTCCAAC	0.358													0	0	0	0.001855	0	12	70										T	35360158	C	T	35360158	3	4	15	1	0	0	0	0	1	0	0	0	4055	536	19	2	2229	2	CUL2	10	35360158	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		35360158	100174589	58	3669										
HK1	3098	broad.mit.edu	37	chr10	71149006	71149006	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gacacagtgggcaccatgatGacctgtgcttatgaggagcc	13	10	0	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:71149006G>A	uc001jpl.3	+	14	2090	c.1989G>A	c.(1987-1989)ATG>ATA	p.M663I	HK1_uc001jpg.3_Missense_Mutation_p.M651I|HK1_uc001jph.3_Missense_Mutation_p.M667I|HK1_uc001jpi.3_Missense_Mutation_p.M667I|HK1_uc001jpj.3_Missense_Mutation_p.M698I|HK1_uc001jpk.3_Missense_Mutation_p.M662I|HK1_uc009xqd.2_Missense_Mutation_p.M541I	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	663	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GCACCATGATGACCTGTGCTT	0.527													0	0	0	0.004672	0	3	15										A	71149006	G	A	71149006	3	1	15	1	0	0	0	0	1	0	0	0	7190	1290	45	1	2221	1	HK1	10	71149006	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	35788848	71149006	64385741	59	3670										
KIAA1274	27143	broad.mit.edu	37	chr10	72292376	72292376	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gacccccacacctccctctaGatccacgactttgcccagct	5	20	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:72292376G>T	uc001jrd.3	+	6	915	c.634_splice	c.e6-1	p.I212_splice		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274											ovary(2)|central_nervous_system(1)	3						CCTCCCTCTAGATCCACGACT	0.597													1	0	0.00909568	0.009096	0.00938909	4	70										T	72292376	G	T	72292376	5	4	15	1	0	0	0	0	0	0	1	0	8220	956	33	3	651	3	KIAA1274	10	72292376	Splice_Site	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	1143370	72292376	63242371	60	3671										
C10orf54	64115	broad.mit.edu	37	chr10	73521607	73521607	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cgtgaggttgcggatgggccGgcgctctgagcaggtctgca	18	10	2	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:73521607G>A	uc001jsd.2	-	2	400	c.259C>T	c.(259-261)CGG>TGG	p.R87W	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_5'UTR|C10orf54_uc009xqm.2_Intron|C10orf54_uc001jsf.1_Missense_Mutation_p.R87W	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	87	Ig-like.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						CGGATGGGCCGGCGCTCTGAG	0.652													0	0	0	0.004672	0	3	43										A	73521607	G	A	73521607	3	1	15	1	0	0	0	0	1	0	0	0	1607	1115	39	2	700	2	C10orf54	10	73521607	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	1229231	73521607	62013140	61	3672										
ECD	11319	broad.mit.edu	37	chr10	74896575	74896575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tcctttcagggaagcctcttCgccaggttcgtgtgtttcaa	10	11	3	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:74896575C>T	uc001jtn.2	-	13	1834	c.1591G>A	c.(1591-1593)GAA>AAA	p.E531K	ECD_uc009xqx.2_Missense_Mutation_p.E564K|ECD_uc009xqy.2_Missense_Mutation_p.E488K|ECD_uc001jto.2_Missense_Mutation_p.E230K	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	531					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					GAAGCCTCTTCGCCAGGTTCG	0.448													0	0	0	0.006214	0	9	165										T	74896575	C	T	74896575	3	4	15	1	0	0	0	0	1	0	0	0	4888	893	31	1	351	1	ECD	10	74896575	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	1374968	74896575	60638172	62	3673										
SORCS1	114815	broad.mit.edu	37	chr10	108459108	108459108	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tctggttccattcttggaccGctgcgaacacctgattctca	8	13	3	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:108459108G>A	uc001kym.2	-	9	1285	c.1277C>T	c.(1276-1278)GCG>GTG	p.A426V	SORCS1_uc001kyl.2_Missense_Mutation_p.A426V|SORCS1_uc009xxs.2_Missense_Mutation_p.A426V|SORCS1_uc001kyn.1_Missense_Mutation_p.A426V|SORCS1_uc001kyo.2_Missense_Mutation_p.A426V	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	426	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TTCTTGGACCGCTGCGAACAC	0.478													0	0	0	0.001168	0	5	34										A	108459108	G	A	108459108	3	1	15	1	0	0	0	0	1	0	0	0	14930	1087	38	2	2535	2	SORCS1	10	108459108	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	33562533	108459108	27075639	63	3674										
TRUB1	142940	broad.mit.edu	37	chr10	116731913	116731913	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gctattctgcattaaagaaaGatggacaaagactttcgact	8	7	1	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:116731913G>C	uc001lcd.2	+	6	677	c.616G>C	c.(616-618)GAT>CAT	p.D206H	TRUB1_uc010qsl.1_Missense_Mutation_p.D108H	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	206					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ATTAAAGAAAGATGGACAAAG	0.413													0	0	0	0.014323	0	21	34										C	116731913	G	C	116731913	3	2	15	1	0	0	0	0	1	0	0	0	16599	942	33	1	638	1	TRUB1	10	116731913	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	8272805	116731913	18802834	64	3675										
SEC23IP	11196	broad.mit.edu	37	chr10	121677504	121677504	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	catctgcatgcactctttatGagtcggaacccagacttcaa	7	12	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr10:121677504G>C	uc001leu.1	+	9	1773	c.1701G>C	c.(1699-1701)ATG>ATC	p.M567I	SEC23IP_uc010qtc.1_Missense_Mutation_p.M356I|SEC23IP_uc009xzk.1_5'Flank	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	567					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CACTCTTTATGAGTCGGAACC	0.363													0	0	0	0.010729	0	10	82										C	121677504	G	C	121677504	3	2	15	1	0	0	0	0	1	0	0	0	13993	1290	45	1	1735	1	SEC23IP	10	121677504	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	4945591	121677504	13857243	65	3676										
DCHS1	8642	broad.mit.edu	37	chr11	6661191	6661191	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tagagggggcaggccaccatCtgtggccaccacaatcagct	12	13	2	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:6661191C>T	uc001mem.1	-	2	2064	c.1654G>A	c.(1654-1656)GAT>AAT	p.D552N		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	552	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGCCACCATCTGTGGCCACC	0.547													0	0	0	0.013537	0	13	82										T	6661191	C	T	6661191	3	4	15	1	0	0	0	0	1	0	0	0	4287	913	32	1	8322	1	DCHS1	11	6661191	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		6661191	128345325	66	3677										
PPFIBP2	8495	broad.mit.edu	37	chr11	7642183	7642183	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	taggagttactgcaagagctCaggcacctcaaaatcaaagt	9	9	3	1	rs150433585		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:7642183C>T	uc001mfj.3	+	7	1024	c.636C>T	c.(634-636)CTC>CTT	p.L212L	PPFIBP2_uc010rbb.1_Silent_p.L135L|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Silent_p.L135L|PPFIBP2_uc010rbd.1_Silent_p.L54L|PPFIBP2_uc010rbe.1_Silent_p.L100L|PPFIBP2_uc001mfl.3_Silent_p.L69L	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	212	Potential.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGCAAGAGCTCAGGCACCTCA	0.423													0	0	0	0.00874	0	36	29										T	7642183	C	T	7642183	2	4	15	1	0	0	0	0	0	0	0	1	12314	813	29	1		1	PPFIBP2	11	7642183	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	980992	7642183	127364333	67	3678										
CDCA5	113130	broad.mit.edu	37	chr11	64846850	64846850	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tctctggcattttcttcttcTtacgtttctgtttctcgggt	7	10	6	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:64846850T>A	uc001ocp.2	-	5	818	c.653A>T	c.(652-654)AAG>ATG	p.K218M		NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	218					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						TTTCTTCTTCTTACGTTTCTG	0.567													0	0	0	0.000602	0	4	50										A	64846850	T	A	64846850	3	1	15	1	0	0	0	0	1	0	0	0	3089	1609	56	5	113	5	CDCA5	11	64846850	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	57204667	64846850	70159666	68	3679										
PRCP	5547	broad.mit.edu	37	chr11	82549509	82549509	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gagggccttggtctcacaccCcactgttgaaaacagtcatc	9	13	2	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:82549509C>G	uc001ozs.2	-	8	1307	c.1194G>C	c.(1192-1194)TGG>TGC	p.W398C	PRCP_uc001ozr.2_Missense_Mutation_p.W419C	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	398					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						GTCTCACACCCCACTGTTGAA	0.418													0	0	0	0.010729	0	11	31										G	82549509	C	G	82549509	3	3	15	1	0	0	0	0	1	0	0	0	12449	624	22	4	304	4	PRCP	11	82549509	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	17702659	82549509	52457007	69	3680										
CASP4	837	broad.mit.edu	37	chr11	104825572	104825573	+	Missense_Mutation	DNP	CG	CG	AA													0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gcatagagtctgccatgaccCgaactttgtcttcagtttta							TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:104825572_104825573CG>AA	uc001pid.1	-	2	236_237	c.163_164CG>TT	c.(163-165)CGG>TTG	p.R55L	CASP4_uc001pib.1_5'UTR|CASP4_uc009yxg.1_5'UTR|CASP4_uc010rux.1_Missense_Mutation_p.R55L|CASP4_uc010ruy.1_Missense_Mutation_p.R55L	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	55	CARD.				apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		TGCCATGACCCGAACTTTGTCT	0.386													0	0	0	0.004672	0	9	87										AA	104825573	CG	AA	104825572	3	1	15	1	0	0	0	0	1	0	0	0	2673	652	23	4	997	4	CASP4	11	104825572	Missense_Mutation	DNP	CG	TCGA-BT-A20W-01A-21D-A14W-08	22276063	104825572	30180944	70	3681										
C11orf87	399947	broad.mit.edu	37	chr11	109294575	109294575	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gtcctggttaccctcatcttCtgcctcatcgtgctgtccct	7	16	4	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:109294575C>T	uc001pkn.2	+	2	590	c.216C>T	c.(214-216)TTC>TTT	p.F72F	C11orf87_uc010rwb.1_5'Flank	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	72	Helical; (Potential).					integral to membrane				ovary(2)	2						CCCTCATCTTCTGCCTCATCG	0.572													0	0	0	0.00308	0	8	71										T	109294575	C	T	109294575	2	4	15	1	0	0	0	0	0	0	0	1	1669	912	32	1		1	C11orf87	11	109294575	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	4469003	109294575	25711941	71	3682										
OR6T1	219874	broad.mit.edu	37	chr11	123813872	123813872	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cagctgtaggggccctgagaAcagtggcaagaatgcaggca	15	9	0	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:123813872A>G	uc010sab.1	-	1	674	c.674T>C	c.(673-675)GTT>GCT	p.V225A		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGCCCTGAGAACAGTGGCAAG	0.527													0	0	0	0.001168	0	6	47										G	123813872	A	G	123813872	3	3	15	1	0	0	0	0	1	0	0	0	11210	43	2	5	300	5	OR6T1	11	123813872	Missense_Mutation	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	14519297	123813872	11192644	72	3683										
OPCML	4978	broad.mit.edu	37	chr11	132306671	132306671	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ggcttttgagatatagggagGatctgtgggaaacacacaca	13	6	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr11:132306671G>A	uc001qgs.2	-	5	717	c.667C>T	c.(667-669)CCT>TCT	p.P223S	OPCML_uc001qgu.2_Missense_Mutation_p.P216S|OPCML_uc010sck.1_Missense_Mutation_p.P223S|OPCML_uc001qgt.2_Missense_Mutation_p.P222S|OPCML_uc010scl.1_Missense_Mutation_p.P182S	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	223	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ATATAGGGAGGATCTGTGGGA	0.393													0	0	0	0.004672	0	3	20										A	132306671	G	A	132306671	3	1	15	1	0	0	0	0	1	0	0	0	10874	1174	41	1	382	1	OPCML	11	132306671	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	8492799	132306671	2699845	73	3684										
KCNA1	3736	broad.mit.edu	37	chr12	5020706	5020706	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ttcgagacgcagctcaagacCctggcgcagttccccaacac	9	16	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:5020706C>A	uc001qnh.2	+	2	1267	c.162C>A	c.(160-162)ACC>ACA	p.T54T		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	54					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGCTCAAGACCCTGGCGCAGT	0.637													1	0	2.21704e-12	0.00278	2.55658e-12	23	50										A	5020706	C	A	5020706	2	1	15	1	0	0	0	0	0	0	0	1	8001	610	22	4		4	KCNA1	12	5020706	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		5020706	128831189	74	3685										
ABCC9	10060	broad.mit.edu	37	chr12	22015990	22015990	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cacagagtacctgttcctacTgaaaaatgaaaaagaaaaaa	6	7	0	4			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:22015990T>A	uc001rfi.1	-	18	2258	c.2238_splice	c.e18-1	p.S746_splice	ABCC9_uc001rfh.2_Splice_Site_p.S746_splice|ABCC9_uc001rfj.1_Splice_Site_p.S710_splice	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9						defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGTTCCTACTGAAAAATGAA	0.318													0	0	0	0.009096	0	4	44										A	22015990	T	A	22015990	5	1	15	1	0	0	0	0	0	0	1	0	59	1594	55	5	2639	5	ABCC9	12	22015990	Splice_Site	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	16995284	22015990	111835905	75	3686										
RNFT2	84900	broad.mit.edu	37	chr12	117274059	117274059	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cgccatctgtcaggccgagtTccgagagcctctgattctcc	10	15	4	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:117274059T>C	uc009zwn.2	+	10	1405	c.1172T>C	c.(1171-1173)TTC>TCC	p.F391S	RNFT2_uc001twb.3_Missense_Mutation_p.F391S|RNFT2_uc001twa.3_Missense_Mutation_p.F301S|RNFT2_uc001twc.3_Missense_Mutation_p.F139S	NM_001109903	NP_001103373	Q96EX2	RNFT2_HUMAN	transmembrane protein 118 isoform 1	391	Extracellular (Potential).|RING-type.					integral to membrane	zinc ion binding				0	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		CAGGCCGAGTTCCGAGAGCCT	0.602													0	0	0	0.004672	0	3	6										C	117274059	T	C	117274059	3	2	15	1	0	0	0	0	1	0	0	0	13502	1783	62	5	1206	5	RNFT2	12	117274059	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	95258069	117274059	16577836	76	3687										
NCOR2	9612	broad.mit.edu	37	chr12	124816920	124816920	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ttcttgttgatctcttgcttCttggacttgaccatggcgga	10	9	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr12:124816920C>G	uc010tay.1	-	45	7035	c.6879G>C	c.(6877-6879)AAG>AAC	p.K2293N	NCOR2_uc010taz.1_Missense_Mutation_p.K2277N|NCOR2_uc010tax.1_Missense_Mutation_p.K404N	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2294					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCTCTTGCTTCTTGGACTTGA	0.587											OREG0022237	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	9	111										G	124816920	C	G	124816920	3	3	15	1	0	0	0	0	1	0	0	0	10236	912	32	1	715	1	NCOR2	12	124816920	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	7542861	124816920	9034975	77	3688										
SACS	26278	broad.mit.edu	37	chr13	23906256	23906256	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	catcgtcaaacactaagatgCttgactttaccaatctacca	4	12	2	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:23906256C>G	uc001uon.2	-	10	12348	c.11759G>C	c.(11758-11760)AGC>ACC	p.S3920T	SACS_uc001uoo.2_Missense_Mutation_p.S3773T|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3920					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CACTAAGATGCTTGACTTTAC	0.438													0	0	0	0.004482	0	9	147										G	23906256	C	G	23906256	3	3	15	1	0	0	0	0	1	0	0	0	13804	797	28	4	1984	4	SACS	13	23906256	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		23906256	91263622	78	3689										
SOHLH2	54937	broad.mit.edu	37	chr13	36744906	36744906	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gatcaccaatagcattctctGaggcggagcttgatggaact	11	9	2	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:36744906G>C	uc001uvj.2	-	10	1108	c.1019C>G	c.(1018-1020)TCA>TGA	p.S340*	SOHLH2_uc010tei.1_Nonsense_Mutation_p.S417*	NM_017826	NP_060296	Q9NX45	SOLH2_HUMAN	spermatogenesis and oogenesis specific basic	340					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		AGCATTCTCTGAGGCGGAGCT	0.398													0	0	0	0.001168	0	5	95										C	36744906	G	C	36744906	4	2	15	1	0	0	0	0	0	1	0	0	14924	1294	45	1	266	1	SOHLH2	13	36744906	Nonsense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	12838650	36744906	78424972	79	3690										
NEK5	341676	broad.mit.edu	37	chr13	52661488	52661488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tttaacctgttccttcatttCgtttttcctaaatggcagct	5	10	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:52661488C>T	uc001vge.2	-	15	1518	c.1378G>A	c.(1378-1380)GAA>AAA	p.E460K		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	460							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TCCTTCATTTCGTTTTTCCTA	0.393													0	0	0	0.00278	0	21	74										T	52661488	C	T	52661488	3	4	15	1	0	0	0	0	1	0	0	0	10327	893	31	1	780	1	NEK5	13	52661488	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	15916582	52661488	62508390	80	3691										
TBC1D4	9882	broad.mit.edu	37	chr13	75936294	75936294	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tgcacgccggtgacactgctGcaccgagaccgaaactcctg	11	15	0	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr13:75936294G>A	uc001vjl.1	-	2	1295	c.948C>T	c.(946-948)TGC>TGT	p.C316C	TBC1D4_uc010aer.2_Silent_p.C316C|TBC1D4_uc010aes.2_Silent_p.C316C	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	316	PID 2.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TGACACTGCTGCACCGAGACC	0.637													0	0	0	0.001168	0	5	46										A	75936294	G	A	75936294	2	1	15	1	0	0	0	0	0	0	0	1	15619	1311	46	2		2	TBC1D4	13	75936294	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	23274806	75936294	39233584	81	3692										
OR6S1	341799	broad.mit.edu	37	chr14	21109226	21109226	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cagcaaggaagatacaatgaCgagggaggccaggacaaagt	14	7	0	2	rs150042729		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr14:21109226C>G	uc001vxv.1	-	1	625	c.625G>C	c.(625-627)GTC>CTC	p.V209L		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		GATACAATGACGAGGGAGGCC	0.572													0	0	0	0.000602	0	5	98										G	21109226	C	G	21109226	3	3	15	1	0	0	0	0	1	0	0	0	11209	536	19	4	374	4	OR6S1	14	21109226	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		21109226	86240314	82	3693										
EAPP	55837	broad.mit.edu	37	chr14	34985629	34985629	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gtgatagatttcttccacatCtgtctctgccttctcggcag	8	12	4	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr14:34985629C>G	uc001wsd.1	-	6	854	c.745G>C	c.(745-747)GAT>CAT	p.D249H		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	249					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		TCTTCCACATCTGTCTCTGCC	0.448													0	0	0	0.008291	0	9	195										G	34985629	C	G	34985629	3	3	15	1	0	0	0	0	1	0	0	0	4877	913	32	1	116	1	EAPP	14	34985629	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	13876403	34985629	72363911	83	3694										
EAPP	55837	broad.mit.edu	37	chr14	34985718	34985718	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tgttctctgaggctttatatCttagaacctcctctttgtta	6	9	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr14:34985718C>G	uc001wsd.1	-	6	765	c.656G>C	c.(655-657)AGA>ACA	p.R219T		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	219					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		GGCTTTATATCTTAGAACCTC	0.388													0	0	0	0.004482	0	9	143										G	34985718	C	G	34985718	3	3	15	1	0	0	0	0	1	0	0	0	4877	913	32	1	205	1	EAPP	14	34985718	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	89	34985718	72363822	84	3695										
PYGO1	26108	broad.mit.edu	37	chr15	55841124	55841124	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ttacctgtgtatttgccttgCgctttttcttatctgggctt	8	9	2	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr15:55841124C>T	uc010bfl.1	-	2	175	c.119G>A	c.(118-120)CGC>CAC	p.R40H	PYGO1_uc002adf.1_Missense_Mutation_p.R40H	NM_015617	NP_056432	Q9Y3Y4	PYGO1_HUMAN	pygopus homolog 1	40	Nuclear localization signal (Potential).				Wnt receptor signaling pathway	nucleus	zinc ion binding	p.R40C(1)		ovary(1)|skin(1)	2				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		ATTTGCCTTGCGCTTTTTCTT	0.368													0	0	0	0.001168	0	4	51										T	55841124	C	T	55841124	3	4	15	1	0	0	0	0	1	0	0	0	12863	768	27	2	1148	2	PYGO1	15	55841124	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		55841124	46690268	85	3696										
GOLGA6A	342096	broad.mit.edu	37	chr15	74365122	74365122	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gaggcttagctgggtctctaGctgttggttctggtggctgg	17	7	2	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr15:74365122G>T	uc002axa.1	-	13	1503	c.1462C>A	c.(1462-1464)CTA>ATA	p.L488I		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	488	Potential.										0						TGGGTCTCTAGCTGTTGGTTC	0.612													1	0	7.48243e-07	0.006214	8.40132e-07	7	55										T	74365122	G	T	74365122	3	4	15	1	0	0	0	0	1	0	0	0	6557	962	34	4	643	4	GOLGA6A	15	74365122	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	18523998	74365122	28166270	86	3697										
ST8SIA2	8128	broad.mit.edu	37	chr15	92977602	92977602	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ccagacgctctctctgaggaTcaggtactggtaattaccta	9	11	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr15:92977602T>A	uc002bra.2	+	3	442	c.287T>A	c.(286-288)ATC>AAC	p.I96N	ST8SIA2_uc002brb.2_Missense_Mutation_p.I75N	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	96	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			TCTCTGAGGATCAGGTACTGG	0.453													0	0	0	0.008871	0	18	55										A	92977602	T	A	92977602	3	1	15	1	0	0	0	0	1	0	0	0	15231	1435	50	5	297	5	ST8SIA2	15	92977602	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	18612480	92977602	9553790	87	3698										
ZNF598	90850	broad.mit.edu	37	chr16	2052220	2052220	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tgctcaccctcgttccggcgCgagtgccgtggcgcgtagct	14	15	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:2052220C>T	uc002cof.1	-	7	897	c.882G>A	c.(880-882)TCG>TCA	p.S294S	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	294						intracellular	zinc ion binding			lung(1)|breast(1)	2						CGTTCCGGCGCGAGTGCCGTG	0.692													0	0	0	0.009096	0	4	15										T	2052220	C	T	2052220	2	4	15	1	0	0	0	0	0	0	0	1	18025	755	27	2		2	ZNF598	16	2052220	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		2052220	88302533	88	3699										
KIAA0556	23247	broad.mit.edu	37	chr16	27761348	27761348	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ccgatatcaatattttaccaGcctatgggaaagacccccgc	7	13	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:27761348G>C	uc002dow.2	+	16	3091	c.3067G>C	c.(3067-3069)GCC>CCC	p.A1023P		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1023										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TATTTTACCAGCCTATGGGAA	0.532													0	0	0	0.009096	0	4	43										C	27761348	G	C	27761348	3	2	15	1	0	0	0	0	1	0	0	0	8183	971	34	4	3129	4	KIAA0556	16	27761348	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	25709128	27761348	62593405	89	3700										
SPNS1	83985	broad.mit.edu	37	chr16	28993242	28993242	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tcctagtttcgtcctgtcttCcctgggcttcactgctgtgg	10	13	2	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:28993242C>T	uc010vdi.1	+	8	970	c.830C>T	c.(829-831)TCC>TTC	p.S277F	uc010vct.1_Intron|SPNS1_uc002drx.2_Missense_Mutation_p.S204F|SPNS1_uc002dsa.2_Missense_Mutation_p.S277F|SPNS1_uc002drz.2_Intron|SPNS1_uc010byp.2_Intron|SPNS1_uc010byq.1_Missense_Mutation_p.S209F|LAT_uc010vdj.1_5'Flank	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	277					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						GTCCTGTCTTCCCTGGGCTTC	0.632											OREG0023712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	77										T	28993242	C	T	28993242	3	4	15	1	0	0	0	0	1	0	0	0	15073	855	30	1	856	1	SPNS1	16	28993242	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	1231894	28993242	61361511	90	3701										
CDH11	1009	broad.mit.edu	37	chr16	65016031	65016031	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gcagctgcattttcttggacTtcgtggatgtaacttggggc	13	8	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr16:65016031T>G	uc002eoi.2	-	8	1607	c.1173A>C	c.(1171-1173)GAA>GAC	p.E391D	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.E391D|CDH11_uc010vin.1_Missense_Mutation_p.E265D|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	391	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TTTCTTGGACTTCGTGGATGT	0.498			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.001984	0	6	90										G	65016031	T	G	65016031	3	3	15	1	0	0	0	0	1	0	0	0	3097	1606	56	5	1241	5	CDH11	16	65016031	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	36022789	65016031	25338722	91	3702										
DHX33	56919	broad.mit.edu	37	chr17	5365692	5365692	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cttctgtgcagctttcaccaCtccaaagagcacatctgtgt	7	13	3	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:5365692C>G	uc002gca.2	-	3	627	c.625G>C	c.(625-627)GTG>CTG	p.V209L	DHX33_uc002gbz.2_5'Flank|DHX33_uc002gcb.2_Missense_Mutation_p.V36L|DHX33_uc010clf.2_Intron	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	209	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCTTTCACCACTCCAAAGAGC	0.463													0	0	0	0.009096	0	4	56										G	5365692	C	G	5365692	3	3	15	1	0	0	0	0	1	0	0	0	4506	565	20	4	1538	4	DHX33	17	5365692	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08		5365692	75829518	92	3703										
NEURL4	84461	broad.mit.edu	37	chr17	7226379	7226379	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	atgcgtgcacctgtgcccagCgcatccaggtcacacccata	9	16	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:7226379C>A	uc002gga.1	-	15	2488	c.2481G>T	c.(2479-2481)GCG>GCT	p.A827A	NEURL4_uc002ggb.1_Silent_p.A827A|NEURL4_uc002ggc.1_Silent_p.A173A	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	827	NHR 4.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTGTGCCCAGCGCATCCAGGT	0.602													1	0	8.12818e-05	0.001984	8.81701e-05	7	39										A	7226379	C	A	7226379	2	1	15	1	0	0	0	0	0	0	0	1	10347	755	27	4		4	NEURL4	17	7226379	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	1860687	7226379	73968831	93	3704										
ATP6V0A1	535	broad.mit.edu	37	chr17	40642597	40642597	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aaaaccaacaagtttacctaTggctttcagaacatagtaga	6	8	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:40642597T>G	uc002hzr.2	+	11	1283	c.1116T>G	c.(1114-1116)TAT>TAG	p.Y372*	ATP6V0A1_uc002hzq.2_Nonsense_Mutation_p.Y372*|ATP6V0A1_uc002hzs.2_Nonsense_Mutation_p.Y379*|ATP6V0A1_uc010wgj.1_Nonsense_Mutation_p.Y329*|ATP6V0A1_uc010wgk.1_Nonsense_Mutation_p.Y329*|ATP6V0A1_uc010cyg.2_Nonsense_Mutation_p.Y18*|ATP6V0A1_uc010wgl.1_Nonsense_Mutation_p.Y231*	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	372	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		AGTTTACCTATGGCTTTCAGA	0.373													0	0	0	0.001855	0	13	122										G	40642597	T	G	40642597	4	3	15	1	0	0	0	0	0	1	0	0	1168	1471	51	5	1175	5	ATP6V0A1	17	40642597	Nonsense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	33416218	40642597	40552613	94	3705										
ATP6V0A1	535	broad.mit.edu	37	chr17	40652912	40652912	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tcctcttttcctacccagagTctggttattcaatgttgtat	6	10	3	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:40652912T>C	uc002hzr.2	+	16	2034	c.1867T>C	c.(1867-1869)TCT>CCT	p.S623P	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.S623P|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.S630P|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.S580P|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.S580P|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.S269P|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.S482P	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	623	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CTACCCAGAGTCTGGTTATTC	0.438													0	0	0	0.00308	0	7	134										C	40652912	T	C	40652912	3	2	15	1	0	0	0	0	1	0	0	0	1168	1667	58	5	1946	5	ATP6V0A1	17	40652912	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	10315	40652912	40542298	95	3706										
BRCA1	672	broad.mit.edu	37	chr17	41244840	41244840	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gattttcttccttttgttcaCattcaaaagtgacttttgga	6	7	3	1	rs80357717		TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:41244840C>G	uc002icq.2	-	10	2940	c.2708G>C	c.(2707-2709)TGT>TCT	p.C903S	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.C832S|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.C856S|BRCA1_uc002ict.2_Missense_Mutation_p.C903S|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.C903S|BRCA1_uc002ide.1_Missense_Mutation_p.C734S|BRCA1_uc010cyy.1_Missense_Mutation_p.C903S|BRCA1_uc010whs.1_Missense_Mutation_p.C903S|BRCA1_uc010cyz.2_Missense_Mutation_p.C856S|BRCA1_uc010cza.2_Missense_Mutation_p.C877S|BRCA1_uc010wht.1_Missense_Mutation_p.C607S	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	903					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CTTTTGTTCACATTCAAAAGT	0.403			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	0.010729	0	12	96										G	41244840	C	G	41244840	3	3	15	1	0	0	0	0	1	0	0	0	1498	478	17	4	3009	4	BRCA1	17	41244840	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	591928	41244840	39950370	96	3707										
COIL	8161	broad.mit.edu	37	chr17	55027860	55027860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	catcacaagattcagactccGaggaggaactgggactctct	10	11	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr17:55027860G>A	uc002iuu.2	-	2	774	c.743C>T	c.(742-744)TCG>TTG	p.S248L		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	248	2 X 4 AA repeats of A-R-N-S.|Ser/Thr-rich.					Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					TTCAGACTCCGAGGAGGAACT	0.428													0	0	0	0.00308	0	8	124										A	55027860	G	A	55027860	3	1	15	1	0	0	0	0	1	0	0	0	3665	1059	37	1	1011	1	COIL	17	55027860	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	13783020	55027860	26167350	97	3708										
THOC1	9984	broad.mit.edu	37	chr18	252549	252549	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gaaaactcaccacgttgttgGagcttcctcgtctcccattt	7	13	2	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr18:252549G>C	uc002kkj.3	-	9	707	c.667C>G	c.(667-669)CCA>GCA	p.P223A	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_Missense_Mutation_p.P223A	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	223					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CACGTTGTTGGAGCTTCCTCG	0.398													0	0	0	0.003163	0	12	100										C	252549	G	C	252549	3	2	15	1	0	0	0	0	1	0	0	0	15861	1174	41	1	1358	1	THOC1	18	252549	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08		252549	77824699	98	3709										
PIK3C3	5289	broad.mit.edu	37	chr18	39584404	39584404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	aacttctgggaaaatggaagCcgatggatgtagaggactcc	13	7	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr18:39584404C>T	uc002lap.2	+	10	1127	c.1069C>T	c.(1069-1071)CCG>TCG	p.P357S	PIK3C3_uc010xcl.1_Missense_Mutation_p.P294S	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	357					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						AAAATGGAAGCCGATGGATGT	0.463										TSP Lung(28;0.18)			0	0	0	0.009096	0	3	42										T	39584404	C	T	39584404	3	4	15	1	0	0	0	0	1	0	0	0	11912	739	26	2	1107	2	PIK3C3	18	39584404	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	39331855	39584404	38492844	99	3710										
MUC16	94025	broad.mit.edu	37	chr19	9085813	9085813	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cagagttgacatatggagttGactgtgtctgcacagaaact	11	7	1	4			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:9085813G>C	uc002mkp.2	-	1	6206	c.6002C>G	c.(6001-6003)TCA>TGA	p.S2001*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2001	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATATGGAGTTGACTGTGTCTG	0.468													0	0	0	0.004482	0	9	70										C	9085813	G	C	9085813	4	2	15	1	0	0	0	0	0	1	0	0	9973	1294	45	1	37857	1	MUC16	19	9085813	Nonsense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08		9085813	50043170	100	3711										
ZNF99	7652	broad.mit.edu	37	chr19	22941848	22941848	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	taaaagctttgccacattctTcacatttatatggtttcttc	4	9	3	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:22941848T>G	uc010xrh.1	-	5	590	c.590A>C	c.(589-591)GAA>GCA	p.E197A		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GCCACATTCTTCACATTTATA	0.363													0	0	0	0.000602	0	5	50										G	22941848	T	G	22941848	3	3	15	1	0	0	0	0	1	0	0	0	18201	1783	62	5	2534	5	ZNF99	19	22941848	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	13856035	22941848	36187135	101	3712										
MAP4K1	11184	broad.mit.edu	37	chr19	39086328	39086328	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gatctcaggtgtgcgaagtcCccggactggggacccctccg	14	14	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:39086328C>A	uc002oix.1	-	28	2329	c.2221G>T	c.(2221-2223)GGA>TGA	p.G741*	MAP4K1_uc002oiw.1_Nonsense_Mutation_p.G328*|MAP4K1_uc002oiy.1_Nonsense_Mutation_p.G741*	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	741	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GTGCGAAGTCCCCGGACTGGG	0.592													1	0	1.08611e-07	0.010729	1.24127e-07	11	52										A	39086328	C	A	39086328	4	1	15	1	0	0	0	0	0	1	0	0	9259	632	22	4	362	4	MAP4K1	19	39086328	Nonsense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	16144480	39086328	20042655	102	3713										
FBXO27	126433	broad.mit.edu	37	chr19	39516069	39516069	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	gactaggacagacggactcgCacgatcacactggagttggt	13	10	1	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:39516069C>G	uc002okh.2	-	6	916	c.834G>C	c.(832-834)GTG>GTC	p.V278V		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	278	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GACGGACTCGCACGATCACAC	0.587													0	0	0	0.001168	0	6	113										G	39516069	C	G	39516069	2	3	15	1	0	0	0	0	0	0	0	1	5737	697	25	4		4	FBXO27	19	39516069	Silent	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	429741	39516069	19612914	103	3714										
SAMD4B	55095	broad.mit.edu	37	chr19	39866391	39866391	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ggccgagtccagaggagcttGgggcccgggctgcttttacc	16	12	0	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:39866391G>C	uc002olb.2	+	7	1804	c.769G>C	c.(769-771)GGG>CGG	p.G257R	SAMD4B_uc002ola.2_Missense_Mutation_p.G257R	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	257							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			AGAGGAGCTTGGGGCCCGGGC	0.647													0	0	0	0.010818	0	30	151										C	39866391	G	C	39866391	3	2	15	1	0	0	0	0	1	0	0	0	13822	1348	47	4	779	4	SAMD4B	19	39866391	Missense_Mutation	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08	350322	39866391	19262592	104	3715										
PPFIA3	8541	broad.mit.edu	37	chr19	49641521	49641521	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	agaggagctggagagtcgggTgtccagctctggcttggact	17	8	1	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr19:49641521T>G	uc002pmr.2	+	16	2245	c.1913T>G	c.(1912-1914)GTG>GGG	p.V638G	PPFIA3_uc010yai.1_Intron|PPFIA3_uc010yaj.1_Intron|PPFIA3_uc002pms.2_Missense_Mutation_p.V506G	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	638	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GAGAGTCGGGTGTCCAGCTCT	0.647													0	0	0	0.00308	0	4	22										G	49641521	T	G	49641521	3	3	15	1	0	0	0	0	1	0	0	0	12311	1696	59	5	1971	5	PPFIA3	19	49641521	Missense_Mutation	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08	9775130	49641521	9487462	105	3716										
BACH1	571	broad.mit.edu	37	chr21	30699117	30699117	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	catggactttattctttgtcTcttttacacacatatgacca	4	10	2	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr21:30699117T>G	uc002ynj.2	+	3	1087	c.972T>G	c.(970-972)TCT>TCG	p.S324S	BACH1_uc002ynk.2_Silent_p.S324S|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	324						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						ATTCTTTGTCTCTTTTACACA	0.413													0	0	0	0.008291	0	10	266										G	30699117	T	G	30699117	2	3	15	1	0	0	0	0	0	0	0	1	1283	1538	54	5		5	BACH1	21	30699117	Silent	SNP	T	TCGA-BT-A20W-01A-21D-A14W-08		30699117	17430778	106	3717										
KRTAP24-1	643803	broad.mit.edu	37	chr21	31655055	31655055	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	tttgcaggttggtgcttcacCgtaggattcttggcagtaat	12	7	2	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr21:31655055C>T	uc002ynv.2	-	1	222	c.196G>A	c.(196-198)GGT>AGT	p.G66S		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	66						keratin filament	structural molecule activity				0						GGTGCTTCACCGTAGGATTCT	0.522													0	0	0	0.001168	0	6	84										T	31655055	C	T	31655055	3	4	15	1	0	0	0	0	1	0	0	0	8542	652	23	2	572	2	KRTAP24-1	21	31655055	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	955938	31655055	16474840	107	3718										
DRG1	4733	broad.mit.edu	37	chr22	31816285	31816285	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ttgattgttctggatgtcctGaaacctttgggacataagaa	10	6	1	3			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr22:31816285G>A	uc003aku.2	+	5	587	c.456G>A	c.(454-456)CTG>CTA	p.L152L		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	152	G.				multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1						TGGATGTCCTGAAACCTTTGG	0.408													0	0	0	0.00308	0	8	107										A	31816285	G	A	31816285	2	1	15	1	0	0	0	0	0	0	0	1	4761	1277	45	1		1	DRG1	22	31816285	Silent	SNP	G	TCGA-BT-A20W-01A-21D-A14W-08		31816285	19488281	108	3719										
TMEM184B	25829	broad.mit.edu	37	chr22	38626692	38626692	+	Frame_Shift_Del	DEL	G	G	-													0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cacctgtttgcagaacctcaGaaatccgatggaataagtct							TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chr22:38626692delG	uc003avf.1	-	5	732	c.508delC	c.(508-510)CTGfs	p.L170fs	TMEM184B_uc003avg.1_Frame_Shift_Del_p.L170fs|TMEM184B_uc003avh.1_Frame_Shift_Del_p.L104fs|TMEM184B_uc010gxl.1_RNA	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	170						integral to membrane					0	Melanoma(58;0.045)					CAGAACCTCAGAAATCCGATG	0.607																		7	13	---	---								-	38626692	G	-	38626692	7	5	15	1	0	1	0	1	0	0	0	0	16102	933	33	0	735	0	TMEM184B	22	38626692	Frame_Shift_Del	DEL	G	TCGA-BT-A20W-01A-21D-A14W-08	6810407	38626692	12677874	109	3720										
STARD8	9754	broad.mit.edu	37	chrX	67940175	67940175	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	cagcacgtatttggggtgccAcccctcatccacgtgcagcg	11	15	1	0			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chrX:67940175A>C	uc004dxa.2	+	7	2091	c.1719A>C	c.(1717-1719)CCA>CCC	p.P573P	STARD8_uc004dxb.2_Silent_p.P653P|STARD8_uc004dxc.3_Silent_p.P573P	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	573	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						TTGGGGTGCCACCCCTCATCC	0.577													0	0	0	0.001168	0	4	4										C	67940175	A	C	67940175	2	2	15	1	0	0	0	0	0	0	0	1	15262	146	6	5		5	STARD8	23	67940175	Silent	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08		67940175	87330385	110	3721										
SLC6A14	11254	broad.mit.edu	37	chrX	115573895	115573895	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ctgatctccatttttgtgacAatctattacaatgtcataat	4	8	3	2			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chrX:115573895A>G	uc004eqi.2	+	4	491	c.387A>G	c.(385-387)ACA>ACG	p.T129T	SLC6A14_uc011mtm.1_Intron	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	129	Helical; Name=3; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTTTTGTGACAATCTATTACA	0.303													0	0	0	0.001855	0	13	79										G	115573895	A	G	115573895	2	3	15	1	0	0	0	0	0	0	0	1	14677	117	5	5		5	SLC6A14	23	115573895	Silent	SNP	A	TCGA-BT-A20W-01A-21D-A14W-08	47633720	115573895	39696665	111	3722										
ODZ1	10178	broad.mit.edu	37	chrX	123556134	123556134	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.223214285714286	25	7.67236063550623e-05	2.25839475839476	3.68819226750261	1.3369696969697	0.105960551184913	0.222910348383572	14	ggtcatacctgaaaaacagtCacagtttggatcaattttgc	8	8	3	1			TCGA-BT-A20W-01A-21D-A14W-08	TCGA-BT-A20W-11A-11D-A14W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	85ccdf9b-f787-4701-822f-ae0fce5b4fc5	824f6ffa-5c80-43aa-a9ca-3c6b1979e9c4	g.chrX:123556134C>G	uc004euj.2	-	23	4502	c.4438G>C	c.(4438-4440)GAC>CAC	p.D1480H	ODZ1_uc011muj.1_Missense_Mutation_p.D1486H|ODZ1_uc010nqy.2_Missense_Mutation_p.D1487H	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1480	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GAAAAACAGTCACAGTTTGGA	0.438													0	0	0	0.004482	0	9	46										G	123556134	C	G	123556134	3	3	15	1	0	0	0	0	1	0	0	0	10834	826	29	1	3775	1	ODZ1	23	123556134	Missense_Mutation	SNP	C	TCGA-BT-A20W-01A-21D-A14W-08	7982239	123556134	31714426	112	3723										
ATAD3A	55210	broad.mit.edu	37	chr1	1451459	1451459	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcagttggagcaacagtcCaagctcaaagtgagtggggc	14	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:1451459C>G	uc001afz.1	+	2	367	c.273C>G	c.(271-273)TCC>TCG	p.S91S	ATAD3A_uc001aga.1_Silent_p.S91S|ATAD3A_uc001agb.1_Silent_p.S12S	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	91							ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		AGCAACAGTCCAAGCTCAAAG	0.632													0	0	0	0.00245	0	13	26										G	1451459	C	G	1451459	2	3	16	1	0	0	0	0	0	0	0	1	1073	581	21	4		4	ATAD3A	1	1451459	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08		1451459	247799162	1	3724										
ARHGEF16	27237	broad.mit.edu	37	chr1	3386012	3386012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacaggccatgttcgagatcCtcacgtcggagttctcctac	9	14	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:3386012C>T	uc001akg.3	+	6	1125	c.877C>T	c.(877-879)CTC>TTC	p.L293F	ARHGEF16_uc001aki.2_Missense_Mutation_p.L5F|ARHGEF16_uc001akj.2_Missense_Mutation_p.L5F|ARHGEF16_uc009vli.1_5'Flank|ARHGEF16_uc010nzh.1_5'Flank	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	293	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GTTCGAGATCCTCACGTCGGA	0.627													0	0	0	0.004656	0	23	41										T	3386012	C	T	3386012	3	4	16	1	0	0	0	0	1	0	0	0	899	681	24	2	895	2	ARHGEF16	1	3386012	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1934553	3386012	245864609	2	3725										
AJAP1	55966	broad.mit.edu	37	chr1	4832502	4832502	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcagtgttctcacgagtgCgtcagggcatctgtgcccgt	13	12	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:4832502C>T	uc001alm.1	+	4	1461	c.1080C>T	c.(1078-1080)TGC>TGT	p.C360C	AJAP1_uc001aln.2_Silent_p.C360C	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	360	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CTCACGAGTGCGTCAGGGCAT	0.592													0	0	0	0.006214	0	9	32										T	4832502	C	T	4832502	2	4	16	1	0	0	0	0	0	0	0	1	438	776	27	2		2	AJAP1	1	4832502	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1446490	4832502	244418119	3	3726										
CHD5	26038	broad.mit.edu	37	chr1	6189100	6189100	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tagatcatcaccttcttgttCtggccgatgcggtgggcgcg	13	11	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:6189100C>T	uc001amb.1	-	23	3517	c.3417G>A	c.(3415-3417)CAG>CAA	p.Q1139Q	CHD5_uc001alz.1_5'UTR|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1139	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCTTCTTGTTCTGGCCGATGC	0.642													0	0	0	0.008871	0	18	26										T	6189100	C	T	6189100	2	4	16	1	0	0	0	0	0	0	0	1	3328	912	32	1		1	CHD5	1	6189100	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1356598	6189100	243061521	4	3727										
UBE4B	10277	broad.mit.edu	37	chr1	10211454	10211454	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccttgttgtgatgttgtgcAaccagaactacatccgaaac	8	10	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:10211454A>G	uc001aqs.3	+	21	3474	c.2761A>G	c.(2761-2763)AAC>GAC	p.N921D	UBE4B_uc001aqr.3_Missense_Mutation_p.N792D|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.N376D|UBE4B_uc001aqt.1_Missense_Mutation_p.N261D	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	921					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GATGTTGTGCAACCAGAACTA	0.458													0	0	0	0.00245	0	14	99										G	10211454	A	G	10211454	3	3	16	1	0	0	0	0	1	0	0	0	16880	130	5	5	2843	5	UBE4B	1	10211454	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	4022354	10211454	239039167	5	3728										
MASP2	10747	broad.mit.edu	37	chr1	11097835	11097835	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcacaggtgaaacgtggccaTtaggtggcgccatcggataa	14	9	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:11097835T>G	uc001aru.2	-	7	944	c.923A>C	c.(922-924)AAT>ACT	p.N308T		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	308	Sushi 1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		AACGTGGCCATTAGGTGGCGC	0.502											OREG0013096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	14	68										G	11097835	T	G	11097835	3	3	16	1	0	0	0	0	1	0	0	0	9323	1493	52	5	1157	5	MASP2	1	11097835	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	886381	11097835	238152786	6	3729										
SPEN	23013	broad.mit.edu	37	chr1	16265833	16265833	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcccgccctgtgagttctctGagagtcacctgtcccgcctg	10	16	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:16265833G>A	uc001axk.1	+	15	11110	c.10906G>A	c.(10906-10908)GAG>AAG	p.E3636K	SPEN_uc010obp.1_Missense_Mutation_p.E3595K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3636	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGAGTTCTCTGAGAGTCACCT	0.582													0	0	0	0.01441	0	75	156										A	16265833	G	A	16265833	3	1	16	1	0	0	0	0	1	0	0	0	15037	1291	45	1	10964	1	SPEN	1	16265833	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5167998	16265833	232984788	7	3730										
SPEN	23013	broad.mit.edu	37	chr1	16265921	16265921	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gattgtcattgcctccgtgtGagccactgagtggttatcac	11	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:16265921G>A	uc001axk.1	+	15	11198	c.10994G>A	c.(10993-10995)TGA>TAA	p.*3665*	SPEN_uc010obp.1_Silent_p.*3624*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3665					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCCTCCGTGTGAGCCACTGAG	0.552													0	0	0	0.01441	0	73	124										A	16265921	G	A	16265921	2	1	16	1	0	0	0	0	0	0	0	1	15037	1285	45	1		1	SPEN	1	16265921	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	88	16265921	232984700	8	3731										
EPHA2	1969	broad.mit.edu	37	chr1	16464519	16464519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctccgagtagcgcacactggCctcacacggcccgcattccc	9	19	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:16464519C>T	uc001aya.1	-	5	1278	c.1141G>A	c.(1141-1143)GCC>ACC	p.A381T	EPHA2_uc010oca.1_Missense_Mutation_p.A381T	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	381	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CGCACACTGGCCTCACACGGC	0.657													0	0	0	0.001855	0	14	15										T	16464519	C	T	16464519	3	4	16	1	0	0	0	0	1	0	0	0	5167	739	26	2	1841	2	EPHA2	1	16464519	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	198598	16464519	232786102	9	3732										
PADI1	29943	broad.mit.edu	37	chr1	17565174	17565174	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcttccaagagaagaaagaaGagggttatggggaggcagcc	15	6	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:17565174G>A	uc001bah.1	+	13	1614	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	PADI1_uc010oco.1_Missense_Mutation_p.E65K|PADI1_uc010ocp.1_Missense_Mutation_p.E65K|PADI1_uc010ocq.1_5'UTR|PADI1_uc009vpb.1_5'Flank	NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	508					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GAAGAAAGAAGAGGGTTATGG	0.607													0	0	0	0.000602	0	4	9										A	17565174	G	A	17565174	3	1	16	1	0	0	0	0	1	0	0	0	11377	943	33	1	1572	1	PADI1	1	17565174	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1100655	17565174	231685447	10	3733										
EIF4G3	8672	broad.mit.edu	37	chr1	21212781	21212781	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctgcctttttcaggtgtacAtcttcttttacagaaactgt	6	9	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:21212781A>G	uc001bec.2	-	14	2425	c.2169T>C	c.(2167-2169)GAT>GAC	p.D723D	EIF4G3_uc010odi.1_Silent_p.D327D|EIF4G3_uc010odj.1_Silent_p.D722D|EIF4G3_uc009vpz.2_Silent_p.D443D|EIF4G3_uc001bed.2_Silent_p.D723D|EIF4G3_uc001bef.2_Silent_p.D759D|EIF4G3_uc001bee.2_Silent_p.D729D	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	723	eIF3/EIF4A-binding (By similarity).				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCAGGTGTACATCTTCTTTTA	0.423													0	0	0	0.012213	0	34	139										G	21212781	A	G	21212781	2	3	16	1	0	0	0	0	0	0	0	1	5038	214	8	5		5	EIF4G3	1	21212781	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3647607	21212781	228037840	11	3734										
HNRNPR	10236	broad.mit.edu	37	chr1	23637803	23637803	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctatttctttgccattcaTttcatccatagcctataaaa	2	10	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:23637803T>C	uc001bgr.3	-	10	1339	c.1180A>G	c.(1180-1182)ATG>GTG	p.M394V	HNRNPR_uc001bgo.2_Missense_Mutation_p.M4V|HNRNPR_uc001bgp.3_Missense_Mutation_p.M397V|HNRNPR_uc009vqk.2_Missense_Mutation_p.M296V|HNRNPR_uc001bgs.3_Missense_Mutation_p.M293V|HNRNPR_uc010odw.1_Missense_Mutation_p.M356V|HNRNPR_uc010odx.1_Missense_Mutation_p.M234V|HNRNPR_uc009vql.2_Missense_Mutation_p.M255V	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	394	RRM 3.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		TTGCCATTCATTTCATCCATA	0.328													0	0	0	0.004672	0	3	23										C	23637803	T	C	23637803	3	2	16	1	0	0	0	0	1	0	0	0	7272	1493	52	5	729	5	HNRNPR	1	23637803	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	2425022	23637803	225612818	12	3735										
MYOM3	127294	broad.mit.edu	37	chr1	24383902	24383902	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccccgtgcttgaacacactGatggtgacctggcccgtctc	10	15	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:24383902G>A	uc001bin.3	-	37	4429	c.4266C>T	c.(4264-4266)ATC>ATT	p.I1422I	MYOM3_uc001bil.3_Silent_p.I315I|MYOM3_uc001bim.3_Silent_p.I1079I	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1422	Ig-like C2-type 4.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGAACACACTGATGGTGACCT	0.562													0	0	0	0.013537	0	13	41										A	24383902	G	A	24383902	2	1	16	1	0	0	0	0	0	0	0	1	10093	1280	45	1		1	MYOM3	1	24383902	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	746099	24383902	224866719	13	3736										
AHDC1	27245	broad.mit.edu	37	chr1	27874267	27874267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctgggggaatcgtagtgggGctggcccagcggcaggtccc	19	11	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:27874267G>A	uc009vsy.2	-	6	5329	c.4360C>T	c.(4360-4362)CCC>TCC	p.P1454S	AHDC1_uc009vsz.1_Missense_Mutation_p.P1454S	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1454							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TCGTAGTGGGGCTGGCCCAGC	0.692													0	0	0	0.001168	0	5	13										A	27874267	G	A	27874267	3	1	16	1	0	0	0	0	1	0	0	0	412	1203	42	2	455	2	AHDC1	1	27874267	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3490365	27874267	221376354	14	3737										
THRAP3	9967	broad.mit.edu	37	chr1	36752825	36752825	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctccacatatggctcatctCagaaggaggagagtgctgct	12	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:36752825C>T	uc001cae.3	+	4	1218	c.994C>T	c.(994-996)CAG>TAG	p.Q332*	THRAP3_uc001caf.3_Nonsense_Mutation_p.Q332*|THRAP3_uc001cag.1_Nonsense_Mutation_p.Q332*	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	332	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGCTCATCTCAGAAGGAGGA	0.517			T	USP6	aneurysmal bone cysts								0	0	0	0.00245	0	13	32										T	36752825	C	T	36752825	4	4	16	1	0	0	0	0	0	1	0	0	15871	827	29	1	1000	1	THRAP3	1	36752825	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8878558	36752825	212497796	15	3738										
KIAA0754	643314	broad.mit.edu	37	chr1	39876750	39876750	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtttagctaagggaggcttCagtgagaagcagcaccccct	12	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:39876750C>T	uc009vvt.1	+	1	1575	c.813C>T	c.(811-813)TTC>TTT	p.F271F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	135											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGGGAGGCTTCAGTGAGAAGC	0.512											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	12										T	39876750	C	T	39876750	2	4	16	1	0	0	0	0	0	0	0	1	8192	825	29	1		1	KIAA0754	1	39876750	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3123925	39876750	209373871	16	3739										
KIAA0467	23334	broad.mit.edu	37	chr1	43909302	43909302	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgagtcagggtctgggagccGagaggcccccacaagctgtg	16	11	2	2	rs141085666		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:43909302G>A	uc001cjk.1	+	47	6425	c.5963G>A	c.(5962-5964)CGA>CAA	p.R1988Q	KIAA0467_uc001cjl.1_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2887						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCTGGGAGCCGAGAGGCCCCC	0.602													0	0	0	0.008871	0	19	68										A	43909302	G	A	43909302	3	1	16	1	0	0	0	0	1	0	0	0	8178	1058	37	1	6141	1	KIAA0467	1	43909302	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4032552	43909302	205341319	17	3740										
KIAA0467	23334	broad.mit.edu	37	chr1	43913626	43913626	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgaggagcaaggagaggctGagcggcacgttctgcggtca	17	8	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:43913626G>A	uc001cjk.1	+	53	7312	c.6850G>A	c.(6850-6852)GAG>AAG	p.E2284K	KIAA0467_uc001cjl.1_Missense_Mutation_p.E272K	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3183						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGGAGAGGCTGAGCGGCACGT	0.572													0	0	0	0.004878	0	38	49										A	43913626	G	A	43913626	3	1	16	1	0	0	0	0	1	0	0	0	8178	1291	45	1	7052	1	KIAA0467	1	43913626	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4324	43913626	205336995	18	3741										
KDM4A	9682	broad.mit.edu	37	chr1	44169946	44169946	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgagattttcacagagaaaGaggttaagcaagaaaagaaa	10	3	1	5			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:44169946G>A	uc001cjx.2	+	22	3266	c.3100G>A	c.(3100-3102)GAG>AAG	p.E1034K	uc001cjy.2_Intron|ST3GAL3_uc009vwu.1_5'Flank|KDM4A_uc010oki.1_3'UTR	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	1034					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						CACAGAGAAAGAGGTTAAGCA	0.443													0	0	0	0.01441	0	48	93										A	44169946	G	A	44169946	3	1	16	1	0	0	0	0	1	0	0	0	8128	943	33	1	3182	1	KDM4A	1	44169946	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	256320	44169946	205080675	19	3742										
PLK3	1263	broad.mit.edu	37	chr1	45268645	45268645	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggtacacgctgctctgcggGagccctccctttgagacggc	13	14	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:45268645G>A	uc001cmn.2	+	7	868	c.768G>A	c.(766-768)GGG>GGA	p.G256G	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	256	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGCTCTGCGGGAGCCCTCCCT	0.622													0	0	0	0.010504	0	18	77										A	45268645	G	A	45268645	2	1	16	1	0	0	0	0	0	0	0	1	12097	1161	41	1		1	PLK3	1	45268645	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1098699	45268645	203981976	20	3743										
MKNK1	8569	broad.mit.edu	37	chr1	47024330	47024330	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggccaggcgtgacttgcaggGaggggaaagcttcatggagc	18	8	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:47024330G>A	uc001cqb.2	-	14	1559	c.1315C>T	c.(1315-1317)CCC>TCC	p.P439S	MKNK1_uc010omd.1_Missense_Mutation_p.P303S|MKNK1_uc001cqc.2_Missense_Mutation_p.P398S|MKNK1_uc009vyi.2_3'UTR|MKNK1_uc010ome.1_3'UTR	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	439					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					GACTTGCAGGGAGGGGAAAGC	0.622													0	0	0	0.001984	0	5	37										A	47024330	G	A	47024330	3	1	16	1	0	0	0	0	1	0	0	0	9604	1174	41	1	86	1	MKNK1	1	47024330	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1755685	47024330	202226291	21	3744										
PCSK9	255738	broad.mit.edu	37	chr1	55523773	55523773	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccgagttgaggcagagactGatccacttctctgccaaaga	11	11	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:55523773G>A	uc001cyf.1	+	8	1536	c.1245G>A	c.(1243-1245)CTG>CTA	p.L415L	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	415	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GGCAGAGACTGATCCACTTCT	0.617													0	0	0	0.005443	0	27	41										A	55523773	G	A	55523773	2	1	16	1	0	0	0	0	0	0	0	1	11606	1277	45	1		1	PCSK9	1	55523773	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	8499443	55523773	193726848	22	3745										
USP24	23358	broad.mit.edu	37	chr1	55566515	55566515	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttactgggtgaaataccttCcaaaaattctcaggtacata	7	8	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:55566515C>T	uc001cyg.3	-	41	4788	c.4788G>A	c.(4786-4788)TGG>TGA	p.W1596*		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1756					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GAAATACCTTCCAAAAATTCT	0.338													0	0	0	0.001984	0	7	19										T	55566515	C	T	55566515	4	4	16	1	0	0	0	0	0	1	0	0	17052	856	30	1	2694	1	USP24	1	55566515	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	42742	55566515	193684106	23	3746										
PRKAA2	5563	broad.mit.edu	37	chr1	57161760	57161760	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatcccagaatatctcaatcGttctgtcgccactctcctga	5	14	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:57161760G>A	uc001cyk.3	+	6	787	c.716G>A	c.(715-717)CGT>CAT	p.R239H		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	239	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TATCTCAATCGTTCTGTCGCC	0.433													0	0	0	0.01441	0	116	132										A	57161760	G	A	57161760	3	1	16	1	0	0	0	0	1	0	0	0	12494	1145	40	2	738	2	PRKAA2	1	57161760	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1595245	57161760	192088861	24	3747										
PRKAA2	5563	broad.mit.edu	37	chr1	57169763	57169763	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgtgaaaaatttgaatgtaCagaatcagaagtaatgaaca	9	3	1	5			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:57169763C>T	uc001cyk.3	+	7	979	c.908C>T	c.(907-909)ACA>ATA	p.T303I		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	303					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TTTGAATGTACAGAATCAGAA	0.383													0	0	0	0.011902	0	43	61										T	57169763	C	T	57169763	3	4	16	1	0	0	0	0	1	0	0	0	12494	478	17	2	934	2	PRKAA2	1	57169763	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8003	57169763	192080858	25	3748										
C8B	732	broad.mit.edu	37	chr1	57399040	57399040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggactccatttccttggcagGgagcacagtggcaggaacta	13	10	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:57399040G>A	uc001cyp.2	-	10	1587	c.1520C>T	c.(1519-1521)CCC>CTC	p.P507L	C8B_uc010oon.1_Missense_Mutation_p.P445L|C8B_uc010ooo.1_Missense_Mutation_p.P455L	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	507	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TCCTTGGCAGGGAGCACAGTG	0.552													0	0	0	0.00632	0	26	46										A	57399040	G	A	57399040	3	1	16	1	0	0	0	0	1	0	0	0	2417	1232	43	2	267	2	C8B	1	57399040	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	229277	57399040	191851581	26	3749										
SAMD13	148418	broad.mit.edu	37	chr1	84791366	84791366	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atcctgcagactgggccgtgAtggatgtcgtcaattatttc	11	9	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:84791366A>G	uc001djr.2	+	3	334	c.142A>G	c.(142-144)ATG>GTG	p.M48V	SAMD13_uc010orw.1_Missense_Mutation_p.M34V|SAMD13_uc010orx.1_Missense_Mutation_p.M34V	NM_001010971	NP_001010971	Q5VXD3	SAM13_HUMAN	sterile alpha motif domain containing 13 isoform	54	SAM.										0				all cancers(265;0.00667)|Epithelial(280;0.0219)|OV - Ovarian serous cystadenocarcinoma(397;0.136)		CTGGGCCGTGATGGATGTCGT	0.488													0	0	0	0.004656	0	27	39										G	84791366	A	G	84791366	3	3	16	1	0	0	0	0	1	0	0	0	13818	333	12	5	152	5	SAMD13	1	84791366	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	27392326	84791366	164459255	27	3750										
COL24A1	255631	broad.mit.edu	37	chr1	86591602	86591602	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgtgtactactaattttttAggtagtaattgtactcctaa	6	5	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:86591602A>C	uc001dlj.2	-	3	459	c.417T>G	c.(415-417)CCT>CCG	p.P139P	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Silent_p.P139P	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	139	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTAATTTTTTAGGTAGTAATT	0.353													0	0	0	0.00333	0	22	18										C	86591602	A	C	86591602	2	2	16	1	0	0	0	0	0	0	0	1	3683	407	15	5		5	COL24A1	1	86591602	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1800236	86591602	162659019	28	3751										
CLCA4	22802	broad.mit.edu	37	chr1	87029431	87029431	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcctttctaccgtgctaagtCaaaaaaaatcgaagcaacaa	6	10	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:87029431C>T	uc009wcs.2	+	4	580	c.536C>T	c.(535-537)TCA>TTA	p.S179L	CLCA4_uc009wct.2_Intron|CLCA4_uc009wcu.2_Intron	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	179						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CGTGCTAAGTCAAAAAAAATC	0.403													0	0	0	0.000602	0	5	38										T	87029431	C	T	87029431	3	4	16	1	0	0	0	0	1	0	0	0	3459	838	29	1	550	1	CLCA4	1	87029431	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	437829	87029431	162221190	29	3752										
RBMXL1	494115	broad.mit.edu	37	chr1	89449393	89449393	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttggtttcacggtcttttatCaagagtacttccactattcg	7	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:89449393C>T	uc009wcx.2	-	3	833	c.117G>A	c.(115-117)TTG>TTA	p.L39L	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Silent_p.L39L	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	39	RRM.						nucleotide binding|RNA binding				0						GGTCTTTTATCAAGAGTACTT	0.423											OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	34	124										T	89449393	C	T	89449393	2	4	16	1	0	0	0	0	0	0	0	1	13153	825	29	1		1	RBMXL1	1	89449393	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2419962	89449393	159801228	30	3753										
GBP7	388646	broad.mit.edu	37	chr1	89615138	89615138	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctggctgtagtggttggctGccctctgcacggctgctgag	16	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:89615138G>A	uc001dna.2	-	7	1128	c.989C>T	c.(988-990)GCA>GTA	p.A330V	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	330						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GTGGTTGGCTGCCCTCTGCAC	0.577													0	0	0	0.01441	0	48	43										A	89615138	G	A	89615138	3	1	16	1	0	0	0	0	1	0	0	0	6279	1319	46	2	947	2	GBP7	1	89615138	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	165745	89615138	159635483	31	3754										
GBP5	115362	broad.mit.edu	37	chr1	89734510	89734510	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatccaaattcccttggtgtGagactgcaccgtagatgcaa	9	10	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:89734510G>A	uc001dnc.2	-	4	757	c.220C>T	c.(220-222)CAC>TAC	p.H74Y	GBP5_uc001dnd.2_Missense_Mutation_p.H74Y|GBP5_uc001dne.1_Missense_Mutation_p.H74Y	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	74						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		CCCTTGGTGTGAGACTGCACC	0.488													0	0	0	0.008871	0	18	46										A	89734510	G	A	89734510	3	1	16	1	0	0	0	0	1	0	0	0	6277	1290	45	1	1576	1	GBP5	1	89734510	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	119372	89734510	159516111	32	3755										
CCDC18	343099	broad.mit.edu	37	chr1	93646363	93646363	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcaggggcccgggaaagggtCagaggcttcctaacgcagac	16	11	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:93646363C>T	uc001dpq.2	+	1	444	c.276C>T	c.(274-276)GTC>GTT	p.V92V	TMED5_uc001dpn.2_5'Flank|TMED5_uc001dpo.2_5'Flank|TMED5_uc001dpp.2_5'Flank	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	Error:Variant_position_missing_in_Q5T9S5_after_alignment										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GGGAAAGGGTCAGAGGCTTCC	0.672													0	0	0	0.001855	0	12	52										T	93646363	C	T	93646363	2	4	16	1	0	0	0	0	0	0	0	1	2794	813	29	1		1	CCDC18	1	93646363	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3911853	93646363	155604258	33	3756										
CCDC76	54482	broad.mit.edu	37	chr1	100598732	100598732	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagccctagaattatggcgaCctccgcgacgtcgccgcacg	12	15	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:100598732C>G	uc001dsv.2	+	1	27	c.8C>G	c.(7-9)ACC>AGC	p.T3S	SASS6_uc001dsu.2_5'Flank|SASS6_uc009wdz.2_5'Flank|CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.T3S	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	3					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		ATTATGGCGACCTCCGCGACG	0.552													0	0	0	0.003954	0	20	30										G	100598732	C	G	100598732	3	3	16	1	0	0	0	0	1	0	0	0	2850	507	18	4	10	4	CCDC76	1	100598732	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6952369	100598732	148651889	34	3757										
SLC25A24	29957	broad.mit.edu	37	chr1	108742614	108742614	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccagagggatgcccaggttCctgagcccctcctgcagctc	11	17	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:108742614C>T	uc001dvn.3	-	1	361	c.147G>A	c.(145-147)AGG>AGA	p.R49R		NM_013386	NP_037518	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 member 24 isoform 1	49	EF-hand 1.|Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TGCCCAGGTTCCTGAGCCCCT	0.721													0	0	0	0.008291	0	8	25										T	108742614	C	T	108742614	2	4	16	1	0	0	0	0	0	0	0	1	14487	854	30	1		1	SLC25A24	1	108742614	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8143882	108742614	140508007	35	3758										
AKNAD1	254268	broad.mit.edu	37	chr1	109380186	109380186	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tattacctcatttgagagtgAagagaaggtggaggccaagt	13	5	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:109380186A>T	uc001dwa.2	-	7	1791	c.1522T>A	c.(1522-1524)TCA>ACA	p.S508T	AKNAD1_uc010ovb.1_Missense_Mutation_p.S215T|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	508										ovary(3)	3						TTTGAGAGTGAAGAGAAGGTG	0.393													0	0	0	0.000602	0	4	62										T	109380186	A	T	109380186	3	4	16	1	0	0	0	0	1	0	0	0	464	246	9	5	1028	5	AKNAD1	1	109380186	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	637572	109380186	139870435	36	3759										
HBXIP	10542	broad.mit.edu	37	chr1	110950397	110950397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aacgtccgcgttctttactgGaaaacatcactgcgcttccg	8	13	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:110950397G>A	uc001dzr.2	-	1	150	c.92C>T	c.(91-93)TCC>TTC	p.S31F		NM_006402	NP_006393	O43504	HBXIP_HUMAN	hepatitis B virus x-interacting protein	Error:Variant_position_missing_in_O43504_after_alignment					anti-apoptosis|negative regulation of caspase activity|response to virus|viral genome replication	cytosol	protein binding			large_intestine(1)|ovary(1)|pancreas(1)	3		all_cancers(81;4.08e-06)|all_epithelial(167;4.38e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0237)|all cancers(265;0.0675)|Epithelial(280;0.0732)|Colorectal(144;0.102)|LUSC - Lung squamous cell carcinoma(189;0.134)		TTCTTTACTGGAAAACATCAC	0.622													0	0	0	0.008291	0	11	26										A	110950397	G	A	110950397	3	1	16	1	0	0	0	0	1	0	0	0	6988	1174	41	1	445	1	HBXIP	1	110950397	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1570211	110950397	138300224	37	3760										
WDR77	79084	broad.mit.edu	37	chr1	111989760	111989760	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgctgagcaaggtcccaaacCttgatgctaagaagcaaaag	10	9	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:111989760C>T	uc001ebb.2	-	4	489	c.450G>A	c.(448-450)AAG>AAA	p.K150K	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Intron|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	150	WD 2.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGTCCCAAACCTTGATGCTAA	0.398													0	0	0	0.00874	0	39	43										T	111989760	C	T	111989760	2	4	16	1	0	0	0	0	0	0	0	1	17324	680	24	2		2	WDR77	1	111989760	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1039363	111989760	137260861	38	3761										
C1orf183	55924	broad.mit.edu	37	chr1	112281828	112281828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagctcctgtttgaggcgacGgagatagcagtccatttccc	11	12	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:112281828G>A	uc001ebo.1	-	1	195	c.37C>T	c.(37-39)CGT>TGT	p.R13C	C1orf183_uc001ebp.1_Intron|uc001ebq.1_5'Flank	NM_019099	NP_061972	Q9NTI7	CA183_HUMAN	hypothetical protein LOC55924 isoform 1	13										ovary(2)	2		all_cancers(81;7.29e-06)|all_epithelial(167;4.98e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.16e-05)		Lung(183;0.0155)|Colorectal(144;0.0289)|all cancers(265;0.0592)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0852)|COAD - Colon adenocarcinoma(174;0.113)		TTGAGGCGACGGAGATAGCAG	0.672													0	0	0	0.008291	0	10	21										A	112281828	G	A	112281828	3	1	16	1	0	0	0	0	1	0	0	0	2019	1116	39	2	864	2	C1orf183	1	112281828	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	292068	112281828	136968793	39	3762										
LRIG2	9860	broad.mit.edu	37	chr1	113638961	113638961	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	catattgctgatggtgtattTagatttctttccaatcttca	6	7	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:113638961T>C	uc001edf.1	+	8	1263	c.1065T>C	c.(1063-1065)TTT>TTC	p.F355F	LRIG2_uc009wgn.1_Silent_p.F252F	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	355	LRR 12.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		ATGGTGTATTTAGATTTCTTT	0.353													0	0	0	0.003755	0	32	51										C	113638961	T	C	113638961	2	2	16	1	0	0	0	0	0	0	0	1	8945	1751	61	5		5	LRIG2	1	113638961	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1357133	113638961	135611660	40	3763										
NHLH2	4808	broad.mit.edu	37	chr1	116380930	116380930	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtccgtgccgcccagggactCcggatccgagtgcgccgagc	15	16	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:116380930C>G	uc009wgz.2	-	2	569	c.64G>C	c.(64-66)GAG>CAG	p.E22Q	NHLH2_uc001efy.2_Missense_Mutation_p.E22Q	NM_001111061	NP_001104531	Q02577	HEN2_HUMAN	nescient helix loop helix 2	22					cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Lung SC(450;0.184)	all_cancers(81;1.75e-06)|all_epithelial(167;1.16e-06)|all_lung(203;9.55e-06)|Lung NSC(69;5.83e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CCCAGGGACTCCGGATCCGAG	0.657													0	0	0	0.009096	0	4	11										G	116380930	C	G	116380930	3	3	16	1	0	0	0	0	1	0	0	0	10404	864	30	1	347	1	NHLH2	1	116380930	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2741969	116380930	132869691	41	3764										
CD101	9398	broad.mit.edu	37	chr1	117556087	117556087	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgctgaagggaaacccttaGaactggtttgcctggttgta	12	7	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:117556087G>A	uc010oxb.1	+	4	959	c.901G>A	c.(901-903)GAA>AAA	p.E301K	CD101_uc009whd.2_Missense_Mutation_p.E301K|CD101_uc010oxc.1_Missense_Mutation_p.E301K|CD101_uc010oxd.1_Missense_Mutation_p.E239K	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	301	Ig-like C2-type 3.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GAAACCCTTAGAACTGGTTTG	0.463													0	0	0	0.003163	0	15	94										A	117556087	G	A	117556087	3	1	16	1	0	0	0	0	1	0	0	0	2962	943	33	1	915	1	CD101	1	117556087	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1175157	117556087	131694534	42	3765										
TTF2	8458	broad.mit.edu	37	chr1	117629135	117629135	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagatcccaggtgcaaacctCaatgtggaggtgaggctggg	16	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:117629135C>G	uc001egy.2	+	12	2171	c.2151C>G	c.(2149-2151)CTC>CTG	p.L717L		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	717	Helicase ATP-binding.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GTGCAAACCTCAATGTGGAGG	0.537													0	0	0	0.004482	0	8	13										G	117629135	C	G	117629135	2	3	16	1	0	0	0	0	0	0	0	1	16716	813	29	1		1	TTF2	1	117629135	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	73048	117629135	131621486	43	3766										
SF3B4	10262	broad.mit.edu	37	chr1	149897916	149897916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtggcactgggggtgggaagGagccaggaggaggcatgcct	21	7	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:149897916G>A	uc001etj.1	-	4	776	c.725C>T	c.(724-726)TCC>TTC	p.S242F	SF3B4_uc001eti.1_Missense_Mutation_p.S6F|SF3B4_uc001etk.1_Missense_Mutation_p.S242F|SF3B4_uc009wll.1_Missense_Mutation_p.S242F	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	242						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GGGTGGGAAGGAGCCAGGAGG	0.582													0	0	0	0.00499	0	15	24										A	149897916	G	A	149897916	3	1	16	1	0	0	0	0	1	0	0	0	14153	1174	41	1	561	1	SF3B4	1	149897916	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	32268781	149897916	99352705	44	3767										
FAM63A	55793	broad.mit.edu	37	chr1	150972380	150972380	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actggagtgtttgcaggtgaTgatcctctccaccagctggt	12	10	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:150972380T>C	uc001ewf.2	-	7	2480	c.796A>G	c.(796-798)ATC>GTC	p.I266V	FAM63A_uc001ewc.2_Missense_Mutation_p.I124V|FAM63A_uc010pcm.1_Missense_Mutation_p.I171V|FAM63A_uc001ewd.2_Missense_Mutation_p.I124V|FAM63A_uc001ewe.2_Missense_Mutation_p.I100V|FAM63A_uc010pcn.1_Missense_Mutation_p.I314V|FAM63A_uc001ewg.2_Missense_Mutation_p.I266V	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	266							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTGCAGGTGATGATCCTCTCC	0.488													0	0	0	0.010504	0	20	59										C	150972380	T	C	150972380	3	2	16	1	0	0	0	0	1	0	0	0	5596	1464	51	5	633	5	FAM63A	1	150972380	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1074464	150972380	98278241	45	3768										
TDRD10	126668	broad.mit.edu	37	chr1	154493838	154493838	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggctccatgcagaaagtgacActtgcaatccaggagctgaa	11	10	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:154493838A>G	uc009wow.2	+	6	1090	c.252A>G	c.(250-252)ACA>ACG	p.T84T	TDRD10_uc001ffd.2_Silent_p.T84T|TDRD10_uc001ffe.2_Silent_p.T5T	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	84	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGAAAGTGACACTTGCAATCC	0.498													0	0	0	0.01441	0	48	127										G	154493838	A	G	154493838	2	3	16	1	0	0	0	0	0	0	0	1	15728	146	6	5		5	TDRD10	1	154493838	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3521458	154493838	94756783	46	3769										
FLAD1	80308	broad.mit.edu	37	chr1	154962650	154962650	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcaggaaattacctgatgtTccaaaccccctccagatcct	6	14	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:154962650T>A	uc001fgf.1	+	4	1635	c.1281T>A	c.(1279-1281)GTT>GTA	p.V427V	FLAD1_uc001fgd.1_Silent_p.V427V|FLAD1_uc001fge.1_Silent_p.V330V|FLAD1_uc001fgg.1_Silent_p.V330V|FLAD1_uc001fgh.1_Missense_Mutation_p.F111Y	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	427	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TACCTGATGTTCCAAACCCCC	0.468													0	0	0	0.01441	0	106	209										A	154962650	T	A	154962650	2	1	16	1	0	0	0	0	0	0	0	1	5920	1770	62	5		5	FLAD1	1	154962650	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	468812	154962650	94287971	47	3770										
INSRR	3645	broad.mit.edu	37	chr1	156818798	156818798	+	Frame_Shift_Del	DEL	C	C	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcgtagcaggatgcggtctgCctccgtcacgttggacacga							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:156818798delC	uc010pht.1	-	7	1740	c.1486delG	c.(1486-1488)GCAfs	p.A496fs	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	496	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ATGCGGTCTGCCTCCGTCACG	0.637																		22	26	---	---								-	156818798	C	-	156818798	7	5	16	1	0	1	0	1	0	0	0	0	7774	739	26	0	2470	0	INSRR	1	156818798	Frame_Shift_Del	DEL	C	TCGA-BT-A2LB-01A-11D-A18F-08	1856148	156818798	92431823	48	3771										
KIRREL	55243	broad.mit.edu	37	chr1	158064160	158064161	+	Missense_Mutation	DNP	CG	CG	AA													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctgcgacaccatcgacaccCgggaggagtatgagatgaag					rs148421111		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:158064160_158064161CG>AA	uc001frn.3	+	14	2181_2182	c.1777_1778CG>AA	c.(1777-1779)CGG>AAG	p.R593K	KIRREL_uc010pib.1_Missense_Mutation_p.R493K|KIRREL_uc009wsq.2_Missense_Mutation_p.R429K|KIRREL_uc001fro.3_Missense_Mutation_p.R407K|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	593	Cytoplasmic (Potential).			DTREEYEMKDPTNGY -> ERPRIRGRLNTSYSD (in Ref. 1).		integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CATCGACACCCGGGAGGAGTAT	0.614													0	0	0	0.004672	0	4	19										AA	158064161	CG	AA	158064160	3	1	16	1	0	0	0	0	1	0	0	0	8324	643	23	4	1831	4	KIRREL	1	158064160	Missense_Mutation	DNP	CG	TCGA-BT-A2LB-01A-11D-A18F-08	1245362	158064160	91186461	49	3772										
OR10K1	391109	broad.mit.edu	37	chr1	158435526	158435526	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagagcccttcatactcccAtgtacttcttccttgccatc	4	16	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:158435526A>T	uc010pij.1	+	1	175	c.175A>T	c.(175-177)ATG>TTG	p.M59L		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCATACTCCCATGTACTTCTT	0.473													0	0	0	0.013114	0	43	131										T	158435526	A	T	158435526	3	4	16	1	0	0	0	0	1	0	0	0	10913	217	8	5	177	5	OR10K1	1	158435526	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	371366	158435526	90815095	50	3773										
FCRLB	127943	broad.mit.edu	37	chr1	161696644	161696644	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttttacaagtacagccgcgcGgtgcgccgcttcgactgggg	14	12	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:161696644G>A	uc001gbh.2	+	7	960	c.726G>A	c.(724-726)GCG>GCA	p.A242A	FCRLB_uc009wus.2_Silent_p.A242A|FCRLB_uc001gbj.2_Missense_Mutation_p.R194Q|FCRLB_uc001gbk.2_Missense_Mutation_p.G208S|FCRLB_uc001gbl.2_Missense_Mutation_p.R187Q|FCRLB_uc001gbm.2_Missense_Mutation_p.G201S|FCRLB_uc001gbi.2_Silent_p.A242A|FCRLB_uc001gbn.3_Missense_Mutation_p.G245S	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	242						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ACAGCCGCGCGGTGCGCCGCT	0.706													0	0	0	0.000602	0	4	5										A	161696644	G	A	161696644	2	1	16	1	0	0	0	0	0	0	0	1	5801	1103	39	2		2	FCRLB	1	161696644	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3261118	161696644	87553977	51	3774										
ILDR2	387597	broad.mit.edu	37	chr1	166926077	166926077	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccacataagctttccaattTgaagatctgcatctgttatc	5	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:166926077T>G	uc001gdx.1	-	3	448	c.392A>C	c.(391-393)CAA>CCA	p.Q131P		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	131	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						CTTTCCAATTTGAAGATCTGC	0.403													0	0	0	0.004482	0	8	44										G	166926077	T	G	166926077	3	3	16	1	0	0	0	0	1	0	0	0	7710	1812	63	5	1559	5	ILDR2	1	166926077	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	5229433	166926077	82324544	52	3775										
DNM3	26052	broad.mit.edu	37	chr1	172357752	172357752	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acaacccaaaggaggccaacActaagtgctcccctcgcaag	8	15	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:172357752A>G	uc001gie.2	+	20	2501	c.2325A>G	c.(2323-2325)ACA>ACG	p.T775T	DNM3_uc001gif.2_Silent_p.T771T|DNM3_uc001gih.1_Silent_p.T131T	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	781					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GGAGGCCAACACTAAGTGCTC	0.562													0	0	0	0.00499	0	15	45										G	172357752	A	G	172357752	2	3	16	1	0	0	0	0	0	0	0	1	4673	146	6	5		5	DNM3	1	172357752	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	5431675	172357752	76892869	53	3776										
TDRD5	163589	broad.mit.edu	37	chr1	179621324	179621324	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtcaaaagagagtgagttaCgtatcttggtaagagatttt	11	3	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:179621324C>T	uc001gnf.1	+	13	2402	c.2152C>T	c.(2152-2154)CGT>TGT	p.R718C	TDRD5_uc010pnp.1_Missense_Mutation_p.R718C|TDRD5_uc001gnh.1_Missense_Mutation_p.R273C	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	718					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GAGTGAGTTACGTATCTTGGT	0.289													0	0	0	0.013537	0	12	25										T	179621324	C	T	179621324	3	4	16	1	0	0	0	0	1	0	0	0	15730	536	19	2	2198	2	TDRD5	1	179621324	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7263572	179621324	69629297	54	3777										
RNF2	6045	broad.mit.edu	37	chr1	185056735	185056735	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcaaccattaagcaaaacatGggaactcagtttatatgagt	7	7	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:185056735G>A	uc001grc.1	+	2	283	c.50G>A	c.(49-51)TGG>TAG	p.W17*	RNF2_uc001grd.1_Nonsense_Mutation_p.W17*	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	17	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		AGCAAAACATGGGAACTCAGT	0.388													0	0	0	0.010818	0	26	66										A	185056735	G	A	185056735	4	1	16	1	0	0	0	0	0	1	0	0	13472	1357	47	2	52	2	RNF2	1	185056735	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5435411	185056735	64193886	55	3778										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185276256	185276256	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gggcaagcaaacattatcttCaagcattacctccaactaga	6	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:185276256C>T	uc001grl.2	-	7	1170	c.547G>A	c.(547-549)GAA>AAA	p.E183K	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	183	Sufficient for AHR interaction and signaling.|BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ACATTATCTTCAAGCATTACC	0.413													0	0	0	0.00245	0	14	29										T	185276256	C	T	185276256	3	4	16	1	0	0	0	0	1	0	0	0	7930	835	29	1	1417	1	IVNS1ABP	1	185276256	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	219521	185276256	63974365	56	3779										
HMCN1	83872	broad.mit.edu	37	chr1	185704134	185704134	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agacgtctttgaaaagacctAaaagacctcttttcaacttt	5	9	3	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:185704134A>G	uc001grq.1	+	1	452	c.223A>G	c.(223-225)AAA>GAA	p.K75E		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	75	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAAGACCTAAAAGACCTCT	0.368													0	0	0	0.00632	0	26	44										G	185704134	A	G	185704134	3	3	16	1	0	0	0	0	1	0	0	0	7220	363	13	5	225	5	HMCN1	1	185704134	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	427878	185704134	63546487	57	3780										
KCNT2	343450	broad.mit.edu	37	chr1	196342326	196342326	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtagatgttgctgggcatatAcagtttaaagctaacatggc	11	6	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:196342326A>G	uc001gtd.1	-	14	1407	c.1347T>C	c.(1345-1347)TGT>TGC	p.C449C	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.C449C|KCNT2_uc001gtf.1_Silent_p.C449C|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.C449C|KCNT2_uc009wyv.1_Silent_p.C424C	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	449	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CTGGGCATATACAGTTTAAAG	0.294													0	0	0	0.003954	0	22	45										G	196342326	A	G	196342326	2	3	16	1	0	0	0	0	0	0	0	1	8092	389	14	5		5	KCNT2	1	196342326	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	10638192	196342326	52908295	58	3781										
ASPM	259266	broad.mit.edu	37	chr1	197111797	197111797	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgattatttattactttttCatgttcacccactgcactgt	4	9	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:197111797C>G	uc001gtu.2	-	3	1842	c.1585G>C	c.(1585-1587)GAA>CAA	p.E529Q	ASPM_uc001gtv.2_Missense_Mutation_p.E529Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	529					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ATTACTTTTTCATGTTCACCC	0.313													0	0	0	0.009535	0	31	95										G	197111797	C	G	197111797	3	3	16	1	0	0	0	0	1	0	0	0	1056	835	29	1	8952	1	ASPM	1	197111797	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	769471	197111797	52138824	59	3782										
NR5A2	2494	broad.mit.edu	37	chr1	200014630	200014630	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acatgtatagaaaaccagaaCtgccaaattgacaaaacaca	5	9	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:200014630C>T	uc001gvb.2	+	4	587	c.381C>T	c.(379-381)AAC>AAT	p.N127N	NR5A2_uc001gvc.2_Silent_p.N81N|NR5A2_uc009wzh.2_Silent_p.N87N|NR5A2_uc010pph.1_Silent_p.N55N	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	127	Nuclear receptor.|NR C4-type.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					AAAACCAGAACTGCCAAATTG	0.328													0	0	0	0.001855	0	14	29										T	200014630	C	T	200014630	2	4	16	1	0	0	0	0	0	0	0	1	10636	564	20	2		2	NR5A2	1	200014630	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2902833	200014630	49235991	60	3783										
PPP1R15B	84919	broad.mit.edu	37	chr1	204379892	204379892	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agcaaataggataccacactGaaattgtctatgcgttgaat	8	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:204379892G>A	uc001hav.3	-	1	1053	c.648C>T	c.(646-648)TTC>TTT	p.F216F		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	216					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			ATACCACACTGAAATTGTCTA	0.498													0	0	0	0.00874	0	42	93										A	204379892	G	A	204379892	2	1	16	1	0	0	0	0	0	0	0	1	12364	1281	45	1		1	PPP1R15B	1	204379892	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4365262	204379892	44870729	61	3784										
DSTYK	25778	broad.mit.edu	37	chr1	205180623	205180623	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgccgccggggccgggacccGagacgggctcgctgccccat	16	18	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:205180623G>A	uc001hbw.2	-	1	105	c.41C>T	c.(40-42)TCG>TTG	p.S14L	DSTYK_uc001hbx.2_Missense_Mutation_p.S14L	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	14						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						GCCGGGACCCGAGACGGGCTC	0.756													0	0	0	0.009096	0	4	5										A	205180623	G	A	205180623	3	1	16	1	0	0	0	0	1	0	0	0	4785	1059	37	1	2800	1	DSTYK	1	205180623	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	800731	205180623	44069998	62	3785										
SLC45A3	85414	broad.mit.edu	37	chr1	205633626	205633626	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gactcacccagcaccatggtCatgaacttctcctctacccc	5	18	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:205633626C>T	uc001hda.1	-	2	498	c.159G>A	c.(157-159)ATG>ATA	p.M53I	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_5'Flank|SLC45A3_uc010prp.1_RNA|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	53	Helical; Name=2; (Potential).				transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			GCACCATGGTCATGAACTTCT	0.572			T	ETV1|ETV5|ELK4|ERG	prostate 								0	0	0	0.01441	0	71	166										T	205633626	C	T	205633626	3	4	16	1	0	0	0	0	1	0	0	0	14642	826	29	1	1518	1	SLC45A3	1	205633626	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	453003	205633626	43616995	63	3786										
PLXNA2	5362	broad.mit.edu	37	chr1	208390236	208390236	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcgggcgggtggtgatactgCttctgccctttggagaagat	15	8	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:208390236C>T	uc001hgz.2	-	2	1790	c.1032G>A	c.(1030-1032)AAG>AAA	p.K344K	PLXNA2_uc001hha.3_Silent_p.K398K	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	344	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GGTGATACTGCTTCTGCCCTT	0.592													0	0	0	0.008871	0	20	30										T	208390236	C	T	208390236	2	4	16	1	0	0	0	0	0	0	0	1	12120	796	28	2		2	PLXNA2	1	208390236	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2756610	208390236	40860385	64	3787										
RPS6KC1	26750	broad.mit.edu	37	chr1	213415584	213415584	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agcccttgatgctttacataGagagggaattgtgtgccgcg	13	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:213415584G>A	uc010ptr.1	+	11	2924	c.2765G>A	c.(2764-2766)AGA>AAA	p.R922K	RPS6KC1_uc001hkd.2_Missense_Mutation_p.R910K|RPS6KC1_uc010pts.1_Missense_Mutation_p.R710K|RPS6KC1_uc010ptt.1_Missense_Mutation_p.R710K|RPS6KC1_uc010ptu.1_Missense_Mutation_p.R741K|RPS6KC1_uc010ptv.1_Missense_Mutation_p.R457K|RPS6KC1_uc001hke.2_Missense_Mutation_p.R741K	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	922	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GCTTTACATAGAGAGGGAATT	0.418													0	0	0	0.00623	0	35	69										A	213415584	G	A	213415584	3	1	16	1	0	0	0	0	1	0	0	0	13658	942	33	1	2807	1	RPS6KC1	1	213415584	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5025348	213415584	35835037	65	3788										
USH2A	7399	broad.mit.edu	37	chr1	216591900	216591900	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttcacaagaattctccccaGtgtcattacttttattggag	6	10	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:216591900G>A	uc001hku.1	-	3	994	c.607C>T	c.(607-609)CTG>TTG	p.L203L	USH2A_uc001hkv.2_Silent_p.L203L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	203	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTCTCCCCAGTGTCATTACT	0.338										HNSCC(13;0.011)			0	0	0	0.004656	0	24	66										A	216591900	G	A	216591900	2	1	16	1	0	0	0	0	0	0	0	1	17033	1020	36	2		2	USH2A	1	216591900	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3176316	216591900	32658721	66	3789										
TP53BP2	7159	broad.mit.edu	37	chr1	223986194	223986194	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgggagatagcagcactctCggctgctgccctgctggttt	13	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:223986194C>T	uc010pvb.1	-	12	1963	c.1671G>A	c.(1669-1671)CCG>CCA	p.P557P	TP53BP2_uc001hod.2_Silent_p.P428P|TP53BP2_uc010puz.1_Intron|TP53BP2_uc010pva.1_Silent_p.P196P	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	551					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCAGCACTCTCGGCTGCTGCC	0.542													0	0	0	0.01441	0	47	116										T	223986194	C	T	223986194	2	4	16	1	0	0	0	0	0	0	0	1	16381	871	31	1		1	TP53BP2	1	223986194	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7394294	223986194	25264427	67	3790										
ACBD3	64746	broad.mit.edu	37	chr1	226340098	226340098	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgctgacagcagtgtttggaGagtctgtccattcaaaatac	10	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:226340098G>A	uc001hpy.2	-	7	1360	c.1313C>T	c.(1312-1314)TCT>TTT	p.S438F		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	438	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		AGTGTTTGGAGAGTCTGTCCA	0.478													0	0	0	0.01441	0	67	110										A	226340098	G	A	226340098	3	1	16	1	0	0	0	0	1	0	0	0	123	942	33	1	281	1	ACBD3	1	226340098	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2353904	226340098	22910523	68	3791										
OBSCN	84033	broad.mit.edu	37	chr1	228467915	228467915	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgacagggccgctacaggatGcagaggccacggaggagggc	18	10	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:228467915G>A	uc009xez.1	+	29	7743	c.7699G>A	c.(7699-7701)GCA>ACA	p.A2567T	OBSCN_uc001hsn.2_Missense_Mutation_p.A2567T|OBSCN_uc001hsp.1_Missense_Mutation_p.A266T|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2567	Ig-like 25.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCTACAGGATGCAGAGGCCAC	0.632													0	0	0	0.013537	0	11	60										A	228467915	G	A	228467915	3	1	16	1	0	0	0	0	1	0	0	0	10812	1319	46	2	7809	2	OBSCN	1	228467915	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2127817	228467915	20782706	69	3792										
NUP133	55746	broad.mit.edu	37	chr1	229625722	229625722	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgaaaaggtggattatattGagtgacttctacagtaactg	10	5	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:229625722G>A	uc001htn.2	-	9	1266	c.1174C>T	c.(1174-1176)CAA>TAA	p.Q392*		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	392					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GGATTATATTGAGTGACTTCT	0.318													0	0	0	0.010504	0	16	23										A	229625722	G	A	229625722	4	1	16	1	0	0	0	0	0	1	0	0	10754	1299	45	1	2368	1	NUP133	1	229625722	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1157807	229625722	19624899	70	3793										
AGT	183	broad.mit.edu	37	chr1	230839024	230839024	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttaagctgttgggtagactCtgtgggctctctctcatccg	12	10	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:230839024C>T	uc001hty.3	-	5	1829	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	AGT_uc009xfe.2_3'UTR|AGT_uc009xff.2_Missense_Mutation_p.E413K	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	441					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	TGGGTAGACTCTGTGGGCTCT	0.527													0	0	0	0.013726	0	32	71										T	230839024	C	T	230839024	3	4	16	1	0	0	0	0	1	0	0	0	399	922	32	1	140	1	AGT	1	230839024	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1213302	230839024	18411597	71	3794										
TTC13	79573	broad.mit.edu	37	chr1	231048454	231048454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttcagcatgatataattgtGtcctttcttccgtggtttga	8	7	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:231048454G>A	uc001huf.3	-	19	2175	c.2144C>T	c.(2143-2145)ACA>ATA	p.T715I	TTC13_uc009xfi.2_Missense_Mutation_p.T662I|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.T661I|TTC13_uc009xfk.1_Missense_Mutation_p.T604I	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	715							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		ATATAATTGTGTCCTTTCTTC	0.318													0	0	0	0.008871	0	19	125										A	231048454	G	A	231048454	3	1	16	1	0	0	0	0	1	0	0	0	16677	1377	48	2	458	2	TTC13	1	231048454	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	209430	231048454	18202167	72	3795										
TTC13	79573	broad.mit.edu	37	chr1	231069546	231069546	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatatgcctgccctagacttTtatatgcatcaataaagtca	5	9	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:231069546T>G	uc001huf.3	-	9	993	c.962A>C	c.(961-963)AAA>ACA	p.K321T	TTC13_uc009xfi.2_Missense_Mutation_p.K268T|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.K268T|TTC13_uc009xfk.1_Missense_Mutation_p.K211T	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	321	TPR 5.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CCCTAGACTTTTATATGCATC	0.343													0	0	0	0.013726	0	27	72										G	231069546	T	G	231069546	3	3	16	1	0	0	0	0	1	0	0	0	16677	1841	64	5	1680	5	TTC13	1	231069546	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	21092	231069546	18181075	73	3796										
SIPA1L2	57568	broad.mit.edu	37	chr1	232551310	232551310	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctgtgtccgggaggggcatCaggccaggatctgcgcactt	16	11	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:232551310C>T	uc001hvg.2	-	17	4850	c.4692G>A	c.(4690-4692)CTG>CTA	p.L1564L	SIPA1L2_uc001hvf.2_Silent_p.L638L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1564					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GGAGGGGCATCAGGCCAGGAT	0.537													0	0	0	0.01441	0	41	92										T	232551310	C	T	232551310	2	4	16	1	0	0	0	0	0	0	0	1	14330	813	29	1		1	SIPA1L2	1	232551310	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1481764	232551310	16699311	74	3797										
ARID4B	51742	broad.mit.edu	37	chr1	235338568	235338568	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttgagatcaggatccttatCaccattctttccacattttc	4	12	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:235338568C>T	uc001hwq.2	-	22	4093	c.3595G>A	c.(3595-3597)GAT>AAT	p.D1199N	ARID4B_uc001hwr.2_Missense_Mutation_p.D1113N|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GGATCCTTATCACCATTCTTT	0.408													0	0	0	0.005443	0	27	64										T	235338568	C	T	235338568	3	4	16	1	0	0	0	0	1	0	0	0	920	826	29	1	355	1	ARID4B	1	235338568	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2787258	235338568	13912053	75	3798										
ARID4B	51742	broad.mit.edu	37	chr1	235338665	235338665	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actgatttgactggctgactCttagttatactttcaccagc	7	10	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:235338665C>G	uc001hwq.2	-	22	3996	c.3498G>C	c.(3496-3498)AAG>AAC	p.K1166N	ARID4B_uc001hwr.2_Missense_Mutation_p.K1080N|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			CTGGCTGACTCTTAGTTATAC	0.358													0	0	0	0.005443	0	26	57										G	235338665	C	G	235338665	3	3	16	1	0	0	0	0	1	0	0	0	920	912	32	1	452	1	ARID4B	1	235338665	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	97	235338665	13911956	76	3799										
OR2M3	127062	broad.mit.edu	37	chr1	248367166	248367166	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	catacggcccacatctgatcGctccccaacacaggacaaga	7	16	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:248367166G>T	uc010pzg.1	+	1	797	c.797G>T	c.(796-798)CGC>CTC	p.R266L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACATCTGATCGCTCCCCAACA	0.502													1	0	3.74213e-36	0.01441	4.06774e-36	58	110										T	248367166	G	T	248367166	3	4	16	1	0	0	0	0	1	0	0	0	11011	1087	38	4	799	4	OR2M3	1	248367166	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	13028501	248367166	883455	77	3800										
SNTG2	54221	broad.mit.edu	37	chr2	1133464	1133464	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atctgttcaggttaatggcaTacatgtagaaaatgcaactc	8	7	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:1133464T>C	uc002qwq.2	+	6	508	c.380T>C	c.(379-381)ATA>ACA	p.I127T	SNTG2_uc002qwp.2_RNA|SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	127	PDZ.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTTAATGGCATACATGTAGAA	0.269													0	0	0	0.00632	0	26	45										C	1133464	T	C	1133464	3	2	16	1	0	0	0	0	1	0	0	0	14875	1406	49	5	402	5	SNTG2	2	1133464	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08		1133464	242065909	78	3801										
ALLC	55821	broad.mit.edu	37	chr2	3730543	3730543	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tattgctagctaaaatccgaCgactggagttacttggttcc	9	9	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:3730543C>T	uc010ewt.2	+	7	551	c.390C>T	c.(388-390)GAC>GAT	p.D130D		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	149							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		TAAAATCCGACGACTGGAGTT	0.428										HNSCC(21;0.051)			0	0	0	0.008361	0	30	96										T	3730543	C	T	3730543	2	4	16	1	0	0	0	0	0	0	0	1	534	535	19	2		2	ALLC	2	3730543	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2597079	3730543	239468830	79	3802										
FAM84A	151354	broad.mit.edu	37	chr2	14774914	14774914	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acctcatccgcgagaagcgcCgtatcgacgccagcggccgc	12	17	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:14774914C>T	uc002rbz.1	+	2	1053	c.811C>T	c.(811-813)CGT>TGT	p.R271C	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	271										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			CGAGAAGCGCCGTATCGACGC	0.667													0	0	0	0.001168	0	5	30										T	14774914	C	T	14774914	3	4	16	1	0	0	0	0	1	0	0	0	5641	652	23	2	813	2	FAM84A	2	14774914	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	11044371	14774914	228424459	80	3803										
MYCN	4613	broad.mit.edu	37	chr2	16082291	16082291	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tacccggacgaagatgacttCtacttcggcggccccgactc	10	15	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:16082291C>T	uc002rci.2	+	2	405	c.105C>T	c.(103-105)TTC>TTT	p.F35F	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Silent_p.F27F	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	35					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			AAGATGACTTCTACTTCGGCG	0.647			A		neuroblastoma								0	0	0	0.006122	0	16	36										T	16082291	C	T	16082291	2	4	16	1	0	0	0	0	0	0	0	1	10021	912	32	1		1	MYCN	2	16082291	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1307377	16082291	227117082	81	3804										
RAD51AP2	729475	broad.mit.edu	37	chr2	17697834	17697834	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttccactatattttttggatActtcaaataaagcatgcact	4	8	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:17697834A>G	uc002rcl.1	-	1	1873	c.1849T>C	c.(1849-1851)TAT>CAT	p.Y617H	RAD51AP2_uc010exn.1_Missense_Mutation_p.Y608H	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	617										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTTTTGGATACTTCAAATAA	0.269													0	0	0	0.00308	0	8	9										G	17697834	A	G	17697834	3	3	16	1	0	0	0	0	1	0	0	0	12987	391	14	5	1642	5	RAD51AP2	2	17697834	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1615543	17697834	225501539	82	3805										
PUM2	23369	broad.mit.edu	37	chr2	20455083	20455083	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttactctgcagccataaggaTgagttgaaagcacaaatacc	8	9	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:20455083T>G	uc002rds.1	-	17	2665	c.2642A>C	c.(2641-2643)CAT>CCT	p.H881P	PUM2_uc002rdq.1_Missense_Mutation_p.H260P|PUM2_uc002rdt.1_Missense_Mutation_p.H881P|PUM2_uc002rdr.2_Missense_Mutation_p.H741P|PUM2_uc010yjy.1_Missense_Mutation_p.H802P|PUM2_uc002rdu.1_Missense_Mutation_p.H881P|PUM2_uc010yjz.1_Missense_Mutation_p.H820P	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	883	Pumilio 5.|PUM-HD.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCATAAGGATGAGTTGAAAG	0.383													0	0	0	0.00245	0	14	26										G	20455083	T	G	20455083	3	3	16	1	0	0	0	0	1	0	0	0	12826	1464	51	5	568	5	PUM2	2	20455083	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	2757249	20455083	222744290	83	3806										
NCOA1	8648	broad.mit.edu	37	chr2	24905860	24905860	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgttgtgaactgtgaagggaGaattgtatttgtgtcagaga	14	2	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:24905860G>A	uc002rfk.2	+	6	653	c.395G>A	c.(394-396)AGA>AAA	p.R132K	NCOA1_uc010eye.2_Missense_Mutation_p.R132K|NCOA1_uc002rfi.2_5'UTR|NCOA1_uc002rfj.2_Missense_Mutation_p.R132K|NCOA1_uc002rfl.2_Missense_Mutation_p.R132K	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	132	PAS.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGAAGGGAGAATTGTATTT	0.368			T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.013726	0	32	50										A	24905860	G	A	24905860	3	1	16	1	0	0	0	0	1	0	0	0	10228	942	33	1	409	1	NCOA1	2	24905860	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4450777	24905860	218293513	84	3807										
DTNB	1838	broad.mit.edu	37	chr2	25851188	25851188	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacactgatctcggtggtatGgtccagtgtattaaggccat	11	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:25851188G>A	uc002rgh.2	-	4	464	c.214C>T	c.(214-216)CAT>TAT	p.H72Y	DTNB_uc010yko.1_Missense_Mutation_p.H15Y|DTNB_uc010ykp.1_5'UTR|DTNB_uc002rgo.2_Intron|DTNB_uc002rgi.2_Missense_Mutation_p.H72Y|DTNB_uc002rgj.2_Missense_Mutation_p.H72Y|DTNB_uc002rgk.2_Missense_Mutation_p.H72Y|DTNB_uc002rgl.2_Missense_Mutation_p.H72Y|DTNB_uc002rgq.2_Missense_Mutation_p.H72Y|DTNB_uc002rgm.2_Missense_Mutation_p.H72Y|DTNB_uc002rgn.2_5'UTR|DTNB_uc002rgr.1_Missense_Mutation_p.H61Y|DTNB_uc010ykq.1_5'UTR	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	72						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGGTGGTATGGTCCAGTGTA	0.418													0	0	0	0.010729	0	12	34										A	25851188	G	A	25851188	3	1	16	1	0	0	0	0	1	0	0	0	4789	1348	47	2	1737	2	DTNB	2	25851188	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	945328	25851188	217348185	85	3808										
OTOF	9381	broad.mit.edu	37	chr2	26703759	26703759	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggcccagcaggagccgggcCcggaaggacacaccctcccc	13	18	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:26703759C>G	uc002rhk.2	-	15	1825	c.1698G>C	c.(1696-1698)CGG>CGC	p.R566R	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	566	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGCCGGGCCCGGAAGGACA	0.642													0	0	0	0.003954	0	25	41										G	26703759	C	G	26703759	2	3	16	1	0	0	0	0	0	0	0	1	11303	610	22	4		4	OTOF	2	26703759	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	852571	26703759	216495614	86	3809										
OTOF	9381	broad.mit.edu	37	chr2	26739468	26739468	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acctccacgcacaggctggtCtgaagggagggaggcggtgg	18	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:26739468C>G	uc002rhk.2	-	5	455	c.328_splice	c.e5-1	p.T110_splice	OTOF_uc010ylb.1_Splice_Site	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a						cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGGCTGGTCTGAAGGGAGG	0.537													0	0	0	0.006214	0	10	82										G	26739468	C	G	26739468	5	3	16	1	0	0	0	0	0	0	1	0	11303	927	32	1	6163	1	OTOF	2	26739468	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	35709	26739468	216459905	87	3810										
PREB	10113	broad.mit.edu	37	chr2	27355129	27355129	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcaggagacgacttcatggcCacaggacttggtccgaaggg	15	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27355129C>T	uc002rix.1	-	6	1148	c.895G>A	c.(895-897)GGC>AGC	p.G299S	PREB_uc002riy.1_Missense_Mutation_p.G227S|PREB_uc002riz.1_RNA|PREB_uc002rja.1_Intron	NM_013388	NP_037520	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding protein	299	Cytoplasmic (Potential).|WD 3.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTTCATGGCCACAGGACTTG	0.612													0	0	0	0.003163	0	15	136										T	27355129	C	T	27355129	3	4	16	1	0	0	0	0	1	0	0	0	12470	594	21	2	374	2	PREB	2	27355129	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	615661	27355129	215844244	88	3811										
CAD	790	broad.mit.edu	37	chr2	27440858	27440858	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actatggcatccccccagatGaaatggatgagttcggtctc	10	11	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27440858G>A	uc002rji.2	+	2	358	c.196G>A	c.(196-198)GAA>AAA	p.E66K	CAD_uc010eyw.2_Missense_Mutation_p.E66K	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	66	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CCCCCCAGATGAAATGGATGA	0.502													0	0	0	0.00499	0	17	59										A	27440858	G	A	27440858	3	1	16	1	0	0	0	0	1	0	0	0	2565	1291	45	1	202	1	CAD	2	27440858	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	85729	27440858	215758515	89	3812										
CAD	790	broad.mit.edu	37	chr2	27449800	27449800	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcaagttcctgcgagtcagcAcaaagattgggagctgcatg	13	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27449800A>G	uc002rji.2	+	15	2419	c.2257A>G	c.(2257-2259)ACA>GCA	p.T753A	CAD_uc010eyw.2_Missense_Mutation_p.T690A	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	753	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCGAGTCAGCACAAAGATTGG	0.532													0	0	0	0.01441	0	44	97										G	27449800	A	G	27449800	3	3	16	1	0	0	0	0	1	0	0	0	2565	159	6	5	2315	5	CAD	2	27449800	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	8942	27449800	215749573	90	3813										
ZNF513	130557	broad.mit.edu	37	chr2	27601758	27601758	+	Frame_Shift_Del	DEL	C	C	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacggcccctcacctgtcggCcccccacacagctggcaggc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27601758delC	uc002rkk.2	-	3	575	c.375delG	c.(373-375)GGGfs	p.G125fs	ZNF513_uc002rkj.2_Frame_Shift_Del_p.G63fs	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	125	Gly-rich.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTGTCGGCCCCCCACACA	0.706																		6	9	---	---								-	27601758	C	-	27601758	7	5	16	1	0	1	0	1	0	0	0	0	17955	726	26	0	1258	0	ZNF513	2	27601758	Frame_Shift_Del	DEL	C	TCGA-BT-A2LB-01A-11D-A18F-08	151958	27601758	215597615	91	3814										
LCLAT1	253558	broad.mit.edu	37	chr2	30790955	30790955	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtctcgaagtaatgcatttGctgaaaaaaatggacttcag	9	6	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:30790955G>C	uc002rnj.2	+	6	864	c.655G>C	c.(655-657)GCT>CCT	p.A219P	LCLAT1_uc010ymp.1_Missense_Mutation_p.A57P|LCLAT1_uc002rnk.1_Missense_Mutation_p.A219P|LCLAT1_uc002rnl.2_Missense_Mutation_p.A181P|LCLAT1_uc010ymq.1_Missense_Mutation_p.A181P	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	219					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						TAATGCATTTGCTGAAAAAAA	0.343													0	0	0	0.005443	0	25	46										C	30790955	G	C	30790955	3	2	16	1	0	0	0	0	1	0	0	0	8677	1319	46	4	673	4	LCLAT1	2	30790955	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3189197	30790955	212408418	92	3815										
GALM	130589	broad.mit.edu	37	chr2	38956810	38956810	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaccacaatttctgtctgaaGggatctaaagaaaagcattt	8	7	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:38956810G>A	uc002rqy.2	+	5	999	c.747G>A	c.(745-747)AAG>AAA	p.K249K		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	249					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				TCTGTCTGAAGGGATCTAAAG	0.438													0	0	0	0.008361	0	29	74										A	38956810	G	A	38956810	2	1	16	1	0	0	0	0	0	0	0	1	6205	991	35	2		2	GALM	2	38956810	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	8165855	38956810	204242563	93	3816										
GALM	130589	broad.mit.edu	37	chr2	38958959	38958959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttacacgggcaacttcctgGatggcacattaaagggcaag	11	9	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:38958959G>A	uc002rqy.2	+	6	1111	c.859G>A	c.(859-861)GAT>AAT	p.D287N		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	287					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				CAACTTCCTGGATGGCACATT	0.527													0	0	0	0.010818	0	31	66										A	38958959	G	A	38958959	3	1	16	1	0	0	0	0	1	0	0	0	6205	1174	41	1	881	1	GALM	2	38958959	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2149	38958959	204240414	94	3817										
MAP4K3	8491	broad.mit.edu	37	chr2	39664039	39664039	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcccctgcctttaccttgtaGacgtcgccgtaggtgccgct	11	15	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:39664039G>A	uc002rro.2	-	1	181	c.90C>T	c.(88-90)GTC>GTT	p.V30V	MAP4K3_uc002rrp.2_Silent_p.V30V|uc002rrq.2_Intron|uc002rrr.1_5'Flank	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	30	Protein kinase.|ATP (By similarity).				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TTACCTTGTAGACGTCGCCGT	0.701													0	0	0	0.004482	0	8	14										A	39664039	G	A	39664039	2	1	16	1	0	0	0	0	0	0	0	1	9261	929	33	1		1	MAP4K3	2	39664039	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	705080	39664039	203535334	95	3818										
C2orf61	285051	broad.mit.edu	37	chr2	47378469	47378469	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagtaagtagccacttgcttCtttaacaggtccaggaagtc	10	9	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:47378469C>T	uc002rvs.2	-	3	454	c.327G>A	c.(325-327)AAG>AAA	p.K109K	C2orf61_uc010fbd.2_RNA|C2orf61_uc010yog.1_Silent_p.K109K	NM_173649	NP_775920	Q8N801	CB061_HUMAN	hypothetical protein LOC285051 isoform 2	109								p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CCACTTGCTTCTTTAACAGGT	0.453													0	0	0	0.012213	0	32	72										T	47378469	C	T	47378469	2	4	16	1	0	0	0	0	0	0	0	1	2180	912	32	1		1	C2orf61	2	47378469	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7714430	47378469	195820904	96	3819										
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48848387	48848387	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aatcacctctgtttactcttCagttgccgcacagcttgcac	6	14	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:48848387C>T	uc010yol.1	+	4	2364	c.2317C>T	c.(2317-2319)CAG>TAG	p.Q773*	STON1-GTF2A1L_uc002rwp.1_Nonsense_Mutation_p.Q773*|GTF2A1L_uc002rws.1_Nonsense_Mutation_p.Q69*|GTF2A1L_uc010yom.1_Nonsense_Mutation_p.Q35*|GTF2A1L_uc002rwt.2_Nonsense_Mutation_p.Q69*	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	773					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTTTACTCTTCAGTTGCCGCA	0.408													0	0	0	0.003163	0	15	27										T	48848387	C	T	48848387	4	4	16	1	0	0	0	0	0	1	0	0	15316	827	29	1	2331	1	STON1-GTF2A1L	2	48848387	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1469918	48848387	194350986	97	3820										
NRXN1	9378	broad.mit.edu	37	chr2	50850596	50850596	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttttcagggcaagattgacAtaatcagccgatttcccagt	8	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:50850596A>G	uc010fbq.2	-	6	2566	c.1089T>C	c.(1087-1089)TAT>TAC	p.Y363Y	NRXN1_uc002rxb.3_Silent_p.Y10Y|NRXN1_uc002rxe.3_Silent_p.Y330Y|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	142	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAAGATTGACATAATCAGCCG	0.433													0	0	0	0.01441	0	59	100										G	50850596	A	G	50850596	2	3	16	1	0	0	0	0	0	0	0	1	10665	224	8	5		5	NRXN1	2	50850596	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2002209	50850596	192348777	98	3821										
FAM161A	84140	broad.mit.edu	37	chr2	62067514	62067514	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttacagcgaatataatcctCaacacaaaagtctgtccaca	4	11	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:62067514C>T	uc010ypo.1	-	3	727	c.625G>A	c.(625-627)GAG>AAG	p.E209K	FAM161A_uc002sbm.3_Missense_Mutation_p.E209K|FAM161A_uc002sbn.3_Missense_Mutation_p.E19K|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Missense_Mutation_p.E100K	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	209					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						ATATAATCCTCAACACAAAAG	0.408													0	0	0	0.007413	0	17	106										T	62067514	C	T	62067514	3	4	16	1	0	0	0	0	1	0	0	0	5472	835	29	1	1373	1	FAM161A	2	62067514	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	11216918	62067514	181131859	99	3822										
OTX1	5013	broad.mit.edu	37	chr2	63283050	63283050	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaccgcagcagcctcttatCccatgtcctacggccagggc	9	18	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:63283050C>A	uc002scd.2	+	5	912	c.664C>A	c.(664-666)CCC>ACC	p.P222T	OTX1_uc010ypt.1_Missense_Mutation_p.P156T	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	222						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					AGCCTCTTATCCCATGTCCTA	0.662													1	0	2.94398e-08	0.007413	3.09477e-08	20	36										A	63283050	C	A	63283050	3	1	16	1	0	0	0	0	1	0	0	0	11320	855	30	3	674	3	OTX1	2	63283050	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1215536	63283050	179916323	100	3823										
MEIS1	4211	broad.mit.edu	37	chr2	66664922	66664922	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggagtaggcatcccctccacGatgtatggggacccgcatgc	13	13	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:66664922G>A	uc002sdu.2	+	2	523	c.66G>A	c.(64-66)ACG>ACA	p.T22T	MEIS1_uc002sdt.2_Silent_p.T22T|MEIS1_uc002sdv.2_Silent_p.T20T|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_5'Flank|MEIS1_uc002sdw.1_5'Flank	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	22							sequence-specific DNA binding transcription factor activity				0						TCCCCTCCACGATGTATGGGG	0.602													0	0	0	0.004007	0	14	37										A	66664922	G	A	66664922	2	1	16	1	0	0	0	0	0	0	0	1	9467	1045	37	1		1	MEIS1	2	66664922	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3381872	66664922	176534451	101	3824										
ETAA1	54465	broad.mit.edu	37	chr2	67630885	67630885	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ataatgacaaaatcatgtgtGacttcctgtactaaggagcc	8	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:67630885G>A	uc002sdz.1	+	5	1210	c.1071G>A	c.(1069-1071)GTG>GTA	p.V357V		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	357						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						AATCATGTGTGACTTCCTGTA	0.353													0	0	0	0.00278	0	22	27										A	67630885	G	A	67630885	2	1	16	1	0	0	0	0	0	0	0	1	5267	1277	45	1		1	ETAA1	2	67630885	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	965963	67630885	175568488	102	3825										
ETAA1	54465	broad.mit.edu	37	chr2	67630955	67630955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttactacaagtgattttgagGatgattgggaaaacttacta	9	4	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:67630955G>A	uc002sdz.1	+	5	1280	c.1141G>A	c.(1141-1143)GAT>AAT	p.D381N		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	381						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						TGATTTTGAGGATGATTGGGA	0.363													0	0	0	0.008361	0	28	46										A	67630955	G	A	67630955	3	1	16	1	0	0	0	0	1	0	0	0	5267	1174	41	1	1159	1	ETAA1	2	67630955	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	70	67630955	175568418	103	3826										
PCBP1	5093	broad.mit.edu	37	chr2	70315790	70315790	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcgccaacattaatgagatCcgccagatgtccggggccca	12	13	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:70315790C>T	uc002sgf.2	+	1	1206	c.915C>T	c.(913-915)ATC>ATT	p.I305I	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	305	KH 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						TTAATGAGATCCGCCAGATGT	0.502													0	0	0	0.00333	0	25	39										T	70315790	C	T	70315790	2	4	16	1	0	0	0	0	0	0	0	1	11500	845	30	1		1	PCBP1	2	70315790	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2684835	70315790	172883583	104	3827										
HTRA2	27429	broad.mit.edu	37	chr2	74757805	74757805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caggattcgtggtggctgccGatgggctcattgtcaccaac	13	11	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:74757805G>A	uc002smi.1	+	2	1170	c.568G>A	c.(568-570)GAT>AAT	p.D190N	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.D190N|HTRA2_uc002smk.1_Missense_Mutation_p.D190N|HTRA2_uc002sml.1_Missense_Mutation_p.D190N|HTRA2_uc002smm.1_5'UTR|HTRA2_uc002smn.1_5'UTR|HTRA2_uc010ffl.2_5'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	190	Serine protease.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						GGTGGCTGCCGATGGGCTCAT	0.592													0	0	0	0.012319	0	22	50										A	74757805	G	A	74757805	3	1	16	1	0	0	0	0	1	0	0	0	7454	1058	37	1	574	1	HTRA2	2	74757805	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4442015	74757805	168441568	105	3828										
LRRTM4	80059	broad.mit.edu	37	chr2	77745831	77745831	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgacgtcaggtttgaagatGgtaggtctagggataatcag	15	4	3	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:77745831G>T	uc002snr.2	-	3	1579	c.1164C>A	c.(1162-1164)ACC>ACA	p.T388T	LRRTM4_uc002snq.2_Silent_p.T388T|LRRTM4_uc002sns.2_Silent_p.T388T|LRRTM4_uc002snt.2_Silent_p.T389T	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	388	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GTTTGAAGATGGTAGGTCTAG	0.473													1	0	6.72482e-11	0.003163	7.18314e-11	14	44										T	77745831	G	T	77745831	2	4	16	1	0	0	0	0	0	0	0	1	9042	1335	47	4		4	LRRTM4	2	77745831	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2988026	77745831	165453542	106	3829										
CAPG	822	broad.mit.edu	37	chr2	85629268	85629268	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggggaatggctgtgtacaTgctgtcttcagatctggaaa	13	7	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:85629268T>C	uc002spl.1	-	2	251	c.1A>G	c.(1-3)ATG>GTG	p.M1V	CAPG_uc002spm.1_Missense_Mutation_p.M1V|CAPG_uc010ysq.1_Missense_Mutation_p.M1V|CAPG_uc010fgi.1_Missense_Mutation_p.M1V|CAPG_uc010fgj.1_5'Flank	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	1					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						GCTGTGTACATGCTGTCTTCA	0.522													0	0	0	0.004482	0	6	6										C	85629268	T	C	85629268	3	2	16	1	0	0	0	0	1	0	0	0	2621	1464	51	5	1081	5	CAPG	2	85629268	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	7883437	85629268	157570105	107	3830										
SMYD1	150572	broad.mit.edu	37	chr2	88402598	88402598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctctcaggaagtggtgaagGagatgatacaattctccaag	11	8	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:88402598G>A	uc002ssr.2	+	7	912	c.910G>A	c.(910-912)GAG>AAG	p.E304K	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						AGTGGTGAAGGAGATGATACA	0.443													0	0	0	0.005443	0	25	49										A	88402598	G	A	88402598	3	1	16	1	0	0	0	0	1	0	0	0	14821	1175	41	1	936	1	SMYD1	2	88402598	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2773330	88402598	154796775	108	3831										
TMEM182	130827	broad.mit.edu	37	chr2	103380863	103380863	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	catgagaggcgagcacaactCgacctcctatgactctgcag	10	13	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:103380863C>G	uc010fjb.2	+	3	495	c.308C>G	c.(307-309)TCG>TGG	p.S103W	TMEM182_uc002tcc.3_Missense_Mutation_p.S60W|TMEM182_uc002tcd.3_Missense_Mutation_p.S7W	NM_144632	NP_653233	Q6ZP80	TM182_HUMAN	transmembrane protein 182 precursor	103	Extracellular (Potential).					integral to membrane					0						GAGCACAACTCGACCTCCTAT	0.483													0	0	0	0.006999	0	38	63										G	103380863	C	G	103380863	3	3	16	1	0	0	0	0	1	0	0	0	16098	893	31	1	318	1	TMEM182	2	103380863	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	14978265	103380863	139818510	109	3832										
ANKRD57	65124	broad.mit.edu	37	chr2	110373335	110373335	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaggtgcttccctcgcatctCatcacctacaaactctcaca	4	16	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:110373335C>T	uc002tfb.2	+	1	1425	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.2_5'Flank|SEPT10_uc002tex.2_5'Flank|SEPT10_uc002tey.2_5'Flank|SEPT10_uc010ywv.1_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	ankyrin repeat domain 57	423											0						CCTCGCATCTCATCACCTACA	0.627													0	0	0	0.003954	0	23	38										T	110373335	C	T	110373335	2	4	16	1	0	0	0	0	0	0	0	1	683	813	29	1		1	ANKRD57	2	110373335	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6992472	110373335	132826038	110	3833										
IL1A	3552	broad.mit.edu	37	chr2	113532667	113532667	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgcctggttttccagtatctGaaagtcagtgatagagggtg	13	7	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:113532667G>A	uc002tig.2	-	7	1753	c.793C>T	c.(793-795)CAG>TAG	p.Q265*		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	265					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						TCCAGTATCTGAAAGTCAGTG	0.458													0	0	0	0.007413	0	18	42										A	113532667	G	A	113532667	4	1	16	1	0	0	0	0	0	1	0	0	7650	1299	45	1	26	1	IL1A	2	113532667	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3159332	113532667	129666706	111	3834										
BIN1	274	broad.mit.edu	37	chr2	127834283	127834283	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttccccagcttctggagaacCtgccgaagccaagagagaag	11	12	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:127834283C>T	uc002tns.1	-	2	430	c.85_splice	c.e2-1	p.V29_splice	BIN1_uc010yzf.1_Splice_Site_p.V5_splice|BIN1_uc010yzg.1_Splice_Site_p.V29_splice|BIN1_uc002tnu.1_Splice_Site_p.V29_splice|BIN1_uc002toa.1_Splice_Site_p.V29_splice|BIN1_uc002tnt.1_Splice_Site_p.V29_splice|BIN1_uc002tnv.1_Splice_Site_p.V29_splice|BIN1_uc002tnw.1_Splice_Site_p.V29_splice|BIN1_uc002tnx.1_Splice_Site_p.V29_splice|BIN1_uc002tny.1_Splice_Site_p.V29_splice|BIN1_uc002tnz.1_Splice_Site_p.V29_splice|BIN1_uc002tob.1_Splice_Site_p.V29_splice|BIN1_uc002toc.1_Splice_Site_p.V29_splice	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1						cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCTGGAGAACCTGCCGAAGCC	0.547													0	0	0	0.01441	0	51	79										T	127834283	C	T	127834283	5	4	16	1	0	0	0	0	0	0	1	0	1432	695	24	2	1818	2	BIN1	2	127834283	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	14301616	127834283	115365090	112	3835										
MAP3K2	10746	broad.mit.edu	37	chr2	128093472	128093472	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attggtataatgtagatccaTagactgtccaaaggcaattt	8	6	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:128093472T>C	uc002toj.1	-	4	303	c.238A>G	c.(238-240)ATG>GTG	p.M80V	MAP3K2_uc010flz.1_Missense_Mutation_p.M80V	NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	80	OPR.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TGTAGATCCATAGACTGTCCA	0.323													0	0	0	0.009096	0	3	4										C	128093472	T	C	128093472	3	2	16	1	0	0	0	0	1	0	0	0	9250	1406	49	5	1673	5	MAP3K2	2	128093472	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	259189	128093472	115105901	113	3836										
NCKAP5	344148	broad.mit.edu	37	chr2	133486457	133486457	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcttgccattgggtcttcagCatatccgaatgatgagcatg	11	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:133486457C>G	uc002ttp.2	-	18	5886	c.5512G>C	c.(5512-5514)GCT>CCT	p.A1838P	NCKAP5_uc002ttq.2_Missense_Mutation_p.A519P	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1838							protein binding				0						GGGTCTTCAGCATATCCGAAT	0.537													0	0	0	0.009718	0	43	205										G	133486457	C	G	133486457	3	3	16	1	0	0	0	0	1	0	0	0	10223	710	25	4	229	4	NCKAP5	2	133486457	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5392985	133486457	109712916	114	3837										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135922246	135922246	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggcaggatcattcacaagCtgtttgtgaatgcccagagg	12	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:135922246C>T	uc002tuj.2	+	23	2714	c.2689C>T	c.(2689-2691)CTG>TTG	p.L897L	RAB3GAP1_uc010fnf.2_Silent_p.L897L|RAB3GAP1_uc010fng.2_Silent_p.L722L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	897						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CATTCACAAGCTGTTTGTGAA	0.493													0	0	0	0.010729	0	11	27										T	135922246	C	T	135922246	2	4	16	1	0	0	0	0	0	0	0	1	12935	796	28	2		2	RAB3GAP1	2	135922246	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2435789	135922246	107277127	115	3838										
ZRANB3	84083	broad.mit.edu	37	chr2	135960517	135960517	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aatgtccttcccctgggtttCttatcatttcatttagctgc	6	11	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:135960517C>T	uc002tum.2	-	20	3143	c.3026G>A	c.(3025-3027)AGA>AAA	p.R1009K	ZRANB3_uc002tuk.2_Missense_Mutation_p.R552K|ZRANB3_uc002tul.2_Missense_Mutation_p.R1007K	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	1009						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		CCCTGGGTTTCTTATCATTTC	0.433													0	0	0	0.00308	0	8	22										T	135960517	C	T	135960517	3	4	16	1	0	0	0	0	1	0	0	0	18221	913	32	1	221	1	ZRANB3	2	135960517	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	38271	135960517	107238856	116	3839										
SPOPL	339745	broad.mit.edu	37	chr2	139308578	139308578	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtgaagttcgagcaaaattCaaattttcccttctgaatgc	7	8	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:139308578C>T	uc002tvh.2	+	4	706	c.306C>T	c.(304-306)TTC>TTT	p.F102F		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	102	MATH.					nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GAGCAAAATTCAAATTTTCCC	0.353													0	0	0	0.004656	0	24	56										T	139308578	C	T	139308578	2	4	16	1	0	0	0	0	0	0	0	1	15084	825	29	1		1	SPOPL	2	139308578	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3348061	139308578	103890795	117	3840										
GALNT5	11227	broad.mit.edu	37	chr2	158165086	158165086	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atttcccccacagcttcaacAatttaattacacctggttaa	3	12	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:158165086A>C	uc002tzg.2	+	9	2783	c.2528A>C	c.(2527-2529)CAA>CCA	p.Q843P	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	843	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						CAGCTTCAACAATTTAATTAC	0.388													0	0	0	0.01441	0	117	248										C	158165086	A	C	158165086	3	2	16	1	0	0	0	0	1	0	0	0	6216	130	5	5	2562	5	GALNT5	2	158165086	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	18856508	158165086	85034287	118	3841										
BAZ2B	29994	broad.mit.edu	37	chr2	160257124	160257124	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctacctctagaatttgctGagctcgaagttctttttcca	6	10	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:160257124G>A	uc002uao.2	-	17	3236	c.2884C>T	c.(2884-2886)CAG>TAG	p.Q962*	BAZ2B_uc002uap.2_Nonsense_Mutation_p.Q926*|BAZ2B_uc002uaq.1_Nonsense_Mutation_p.Q792*	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	962	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGAATTTGCTGAGCTCGAAGT	0.259													0	0	0	0.001984	0	7	15										A	160257124	G	A	160257124	4	1	16	1	0	0	0	0	0	1	0	0	1332	1299	45	1	3706	1	BAZ2B	2	160257124	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2092038	160257124	82942249	119	3842										
COBLL1	22837	broad.mit.edu	37	chr2	165586561	165586561	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agctgacaacagatcgattgTgtaacttgatggatttaagt	10	5	0	3	rs146685683		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:165586561T>C	uc010zcw.1	-	5	578	c.454A>G	c.(454-456)ACA>GCA	p.T152A	COBLL1_uc002ucp.2_Missense_Mutation_p.T99A|COBLL1_uc002ucq.2_Missense_Mutation_p.T99A|COBLL1_uc010zcx.1_Missense_Mutation_p.T145A|COBLL1_uc002ucs.1_RNA	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	137										ovary(2)|pancreas(1)	3						AGATCGATTGTGTAACTTGAT	0.343													0	0	0	0.010504	0	20	40										C	165586561	T	C	165586561	3	2	16	1	0	0	0	0	1	0	0	0	3654	1696	59	5	3253	5	COBLL1	2	165586561	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	5329437	165586561	77612812	120	3843										
CSRNP3	80034	broad.mit.edu	37	chr2	166535631	166535631	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagacgaggaggaggaggaaGaagaagaggaagaggaggag	21	2	0	5			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:166535631G>C	uc002udf.2	+	7	1502	c.1126G>C	c.(1126-1128)GAA>CAA	p.E376Q	CSRNP3_uc002udg.2_Missense_Mutation_p.E376Q	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	376	Glu-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						ggaggaggaagaagaagagga	0.423													0	0	0	0.004007	0	17	38										C	166535631	G	C	166535631	3	2	16	1	0	0	0	0	1	0	0	0	3965	943	33	1	1140	1	CSRNP3	2	166535631	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	949070	166535631	76663742	121	3844										
SCN1A	6323	broad.mit.edu	37	chr2	166900510	166900510	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	taaagctgaaaaggcttgttCtgctatttcgccttggtgaa	10	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:166900510C>T	uc010zcz.1	-	11	1730	c.1712G>A	c.(1711-1713)AGA>AAA	p.R571K	SCN1A_uc002udo.3_Missense_Mutation_p.R440K|SCN1A_uc010fpk.2_Missense_Mutation_p.R440K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	571						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AAGGCTTGTTCTGCTATTTCG	0.438													0	0	0	0.004656	0	25	50										T	166900510	C	T	166900510	3	4	16	1	0	0	0	0	1	0	0	0	13914	913	32	1	4381	1	SCN1A	2	166900510	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	364879	166900510	76298863	122	3845										
B3GALT1	8708	broad.mit.edu	37	chr2	168725897	168725897	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atcaagatagccaccctgttCctcctgggcaagaatgctga	9	12	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:168725897C>T	uc002udz.1	+	2	699	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	116	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						CCACCCTGTTCCTCCTGGGCA	0.488													0	0	0	0.008871	0	18	33										T	168725897	C	T	168725897	2	4	16	1	0	0	0	0	0	0	0	1	1247	854	30	1		1	B3GALT1	2	168725897	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1825387	168725897	74473476	123	3846										
LRP2	4036	broad.mit.edu	37	chr2	170175331	170175331	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatcttggtcacacacccagGagttggggatgcattgtccc	12	11	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:170175331G>C	uc002ues.2	-	3	464	c.251C>G	c.(250-252)TCC>TGC	p.S84C	LRP2_uc010zdf.1_Missense_Mutation_p.S84C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	84	LDL-receptor class A 2.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACACCCAGGAGTTGGGGAT	0.468													0	0	0	0.004482	0	7	71										C	170175331	G	C	170175331	3	2	16	1	0	0	0	0	1	0	0	0	8956	1174	41	1	14024	1	LRP2	2	170175331	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1449434	170175331	73024042	124	3847										
RBM45	129831	broad.mit.edu	37	chr2	178977522	178977522	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcacaggcctgcagggccatGgaggagatgcatggccagtg	16	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:178977522G>A	uc002ulv.2	+	1	341	c.249G>A	c.(247-249)ATG>ATA	p.M83I		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	83	RRM 1.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			GCAGGGCCATGGAGGAGATGC	0.647													0	0	0	0.00632	0	25	58										A	178977522	G	A	178977522	3	1	16	1	0	0	0	0	1	0	0	0	13139	1348	47	2	251	2	RBM45	2	178977522	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	8802191	178977522	64221851	125	3848										
TTN	7273	broad.mit.edu	37	chr2	179422796	179422796	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atggtcaggttctcagcagtAatttcggtattaaatctcat	8	7	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:179422796A>G	uc010zfg.1	-	277	79805	c.79581T>C	c.(79579-79581)ATT>ATC	p.I26527I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I20222I|TTN_uc010zfi.1_Silent_p.I20155I|TTN_uc010zfj.1_Silent_p.I20030I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27454							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCAGCAGTAATTTCGGTAT	0.428													0	0	0	0.00623	0	37	80										G	179422796	A	G	179422796	2	3	16	1	0	0	0	0	0	0	0	1	16732	358	13	5		5	TTN	2	179422796	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	445274	179422796	63776577	126	3849										
TTN	7273	broad.mit.edu	37	chr2	179439443	179439443	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcctggtccaactccatatcTattctgagcttttacacgga	7	12	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:179439443T>C	uc010zfg.1	-	275	63936	c.63712A>G	c.(63712-63714)AGA>GGA	p.R21238G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R14933G|TTN_uc010zfi.1_Missense_Mutation_p.R14866G|TTN_uc010zfj.1_Missense_Mutation_p.R14741G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22165							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCATATCTATTCTGAGCT	0.463													0	0	0	0.003271	0	32	55										C	179439443	T	C	179439443	3	2	16	1	0	0	0	0	1	0	0	0	16732	1530	53	5	36711	5	TTN	2	179439443	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	16647	179439443	63759930	127	3850										
TTN	7273	broad.mit.edu	37	chr2	179650673	179650673	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gactgctttagggacaacgtGgggttctgaggctggacgtt	16	7	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:179650673G>C	uc010zfg.1	-	14	2496	c.2272C>G	c.(2272-2274)CAC>GAC	p.H758D	TTN_uc010zfh.1_Missense_Mutation_p.H712D|TTN_uc010zfi.1_Missense_Mutation_p.H712D|TTN_uc010zfj.1_Missense_Mutation_p.H712D|TTN_uc002unb.2_Missense_Mutation_p.H758D|TTN_uc010frg.1_Missense_Mutation_p.H340D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	758							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGACAACGTGGGGTTCTGAG	0.488													0	0	0	0.00632	0	28	45										C	179650673	G	C	179650673	3	2	16	1	0	0	0	0	1	0	0	0	16732	1348	47	4	109112	4	TTN	2	179650673	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	211230	179650673	63548700	128	3851										
BMPR2	659	broad.mit.edu	37	chr2	203420156	203420156	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	accgaaattcaattaactatGaacgacagcaagcacaagct	6	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:203420156G>A	uc002uzf.3	+	12	2916	c.1768G>A	c.(1768-1770)GAA>AAA	p.E590K	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	590	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AATTAACTATGAACGACAGCA	0.463													0	0	0	0.014323	0	24	40										A	203420156	G	A	203420156	3	1	16	1	0	0	0	0	1	0	0	0	1471	1291	45	1	1814	1	BMPR2	2	203420156	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	23769483	203420156	39779217	129	3852										
INO80D	54891	broad.mit.edu	37	chr2	206921331	206921331	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcttgtcgaacttttaaaatCtctgtctctctctggcgctg	7	11	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:206921331C>T	uc002vaz.3	-	4	960	c.555G>A	c.(553-555)GAG>GAA	p.E185E		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	185					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTTTTAAAATCTCTGTCTCTC	0.498													0	0	0	0.000602	0	5	14										T	206921331	C	T	206921331	2	4	16	1	0	0	0	0	0	0	0	1	7749	912	32	1		1	INO80D	2	206921331	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3501175	206921331	36278042	130	3853										
TNS1	7145	broad.mit.edu	37	chr2	218762563	218762563	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacttgagcatctgcgccacCtcacggaggttgctccggaa	12	13	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:218762563C>G	uc002vgt.2	-	6	524	c.126G>C	c.(124-126)GAG>GAC	p.E42D	TNS1_uc002vgr.2_Missense_Mutation_p.E42D|TNS1_uc002vgs.2_Missense_Mutation_p.E42D|TNS1_uc010zjv.1_Missense_Mutation_p.E42D|TNS1_uc010fvj.1_Missense_Mutation_p.E110D|TNS1_uc010fvk.1_Missense_Mutation_p.E167D|TNS1_uc002vgu.3_Missense_Mutation_p.E73D|TNS1_uc002vgv.1_RNA	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	42	Phosphatase tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCTGCGCCACCTCACGGAGGT	0.572													0	0	0	0.008361	0	31	43										G	218762563	C	G	218762563	3	3	16	1	0	0	0	0	1	0	0	0	16340	680	24	4	5193	4	TNS1	2	218762563	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	11841232	218762563	24436810	131	3854										
C2orf62	375307	broad.mit.edu	37	chr2	219229358	219229358	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggctgttgccagcaaaaccTgggcttccagaccatccagg	11	13	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:219229358T>C	uc002vhr.2	+	7	667	c.638T>C	c.(637-639)CTG>CCG	p.L213P	C2orf62_uc002vhs.2_Intron	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	213											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGCAAAACCTGGGCTTCCAG	0.562													0	0	0	0.004878	0	38	51										C	219229358	T	C	219229358	3	2	16	1	0	0	0	0	1	0	0	0	2181	1580	55	5	664	5	C2orf62	2	219229358	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	466795	219229358	23970015	132	3855										
STK36	27148	broad.mit.edu	37	chr2	219537634	219537634	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtcgaagaaaatacagtgctCaggtgttgcacaaagaggga	13	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:219537634C>G	uc002viu.2	+	2	348	c.82C>G	c.(82-84)CAG>GAG	p.Q28E	STK36_uc002viv.2_Missense_Mutation_p.Q28E|RNF25_uc002vit.2_5'Flank|RNF25_uc010fvw.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	28	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		ATACAGTGCTCAGGTGTTGCA	0.443													0	0	0	0.004289	0	37	54										G	219537634	C	G	219537634	3	3	16	1	0	0	0	0	1	0	0	0	15301	827	29	1	84	1	STK36	2	219537634	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	308276	219537634	23661739	133	3856										
CHPF	79586	broad.mit.edu	37	chr2	220406655	220406655	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caggaagaaccagtcaaagtCgtcgccgtgctgctccagca	11	13	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:220406655C>T	uc002vmc.3	-	2	798	c.571G>A	c.(571-573)GAC>AAC	p.D191N	CHPF_uc010zlh.1_Missense_Mutation_p.D29N|CHPF_uc002vmd.3_Missense_Mutation_p.D191N|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	191	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CAGTCAAAGTCGTCGCCGTGC	0.687											OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	12	18										T	220406655	C	T	220406655	3	4	16	1	0	0	0	0	1	0	0	0	3368	884	31	1	1768	1	CHPF	2	220406655	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	869021	220406655	22792718	134	3857										
SCG2	7857	broad.mit.edu	37	chr2	224463114	224463114	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttggtctttactctctttcCgaagatcttcttcctggatg	8	10	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:224463114C>T	uc002vnm.2	-	2	1020	c.887G>A	c.(886-888)CGG>CAG	p.R296Q		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	296					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		ACTCTCTTTCCGAAGATCTTC	0.418													0	0	0	0.006122	0	18	136										T	224463114	C	T	224463114	3	4	16	1	0	0	0	0	1	0	0	0	13891	652	23	2	970	2	SCG2	2	224463114	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4056459	224463114	18736259	135	3858										
SERPINE2	5270	broad.mit.edu	37	chr2	224849561	224849561	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgtgggatgatggcagacagCggagtggagctctcagtcgg	18	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:224849561C>T	uc002vnu.2	-	5	1035	c.792G>A	c.(790-792)CCG>CCA	p.P264P	SERPINE2_uc002vnt.2_Silent_p.P264P|SERPINE2_uc010zlr.1_Silent_p.P276P|SERPINE2_uc002vnv.2_Silent_p.P264P	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	264					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TGGCAGACAGCGGAGTGGAGC	0.537													0	0	0	0.00499	0	18	37										T	224849561	C	T	224849561	2	4	16	1	0	0	0	0	0	0	0	1	14112	755	27	2		2	SERPINE2	2	224849561	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	386447	224849561	18349812	136	3859										
SERPINE2	5270	broad.mit.edu	37	chr2	224856541	224856541	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acaccggaacacggagagctGggccagcattggcacttgat	13	11	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:224856541G>T	uc002vnu.2	-	4	907	c.664C>A	c.(664-666)CAG>AAG	p.Q222K	SERPINE2_uc002vnt.2_Missense_Mutation_p.Q222K|SERPINE2_uc010zlr.1_Missense_Mutation_p.Q234K|SERPINE2_uc002vnv.2_Missense_Mutation_p.Q222K	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	222					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ACGGAGAGCTGGGCCAGCATT	0.527													1	0	1.5842e-08	0.001855	1.67351e-08	14	42										T	224856541	G	T	224856541	3	4	16	1	0	0	0	0	1	0	0	0	14112	1357	47	4	556	4	SERPINE2	2	224856541	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6980	224856541	18342832	137	3860										
COL4A3	1285	broad.mit.edu	37	chr2	228137702	228137702	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggggaccaaggtcctccagGggatcctggctcccctgggt	15	13	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:228137702G>C	uc002vom.1	+	26	1958	c.1796G>C	c.(1795-1797)GGG>GCG	p.G599A	COL4A3_uc002von.1_Missense_Mutation_p.G599A|COL4A3_uc002voo.1_Missense_Mutation_p.G599A|COL4A3_uc002vop.1_Missense_Mutation_p.G599A|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	599	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGTCCTCCAGGGGATCCTGGC	0.557													0	0	0	0.005443	0	26	44										C	228137702	G	C	228137702	3	2	16	1	0	0	0	0	1	0	0	0	3691	1232	43	4	1898	4	COL4A3	2	228137702	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3281161	228137702	15061671	138	3861										
FBXO36	130888	broad.mit.edu	37	chr2	230787323	230787323	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agttactggtcacccggtctCaggcaagtgcgagccgcggt	14	12	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:230787323C>G	uc002vqa.2	+	1	117	c.94C>G	c.(94-96)CAG>GAG	p.Q32E	TRIP12_uc002vpw.1_5'Flank|TRIP12_uc002vpx.1_5'Flank|TRIP12_uc002vpy.1_5'Flank|TRIP12_uc010zlz.1_5'Flank|TRIP12_uc010fxh.1_5'Flank|FBXO36_uc002vpz.2_Missense_Mutation_p.Q32E|FBXO36_uc002vqb.2_5'UTR|FBXO36_uc010fxi.1_Missense_Mutation_p.Q32E|FBXO36_uc002vqc.2_RNA	NM_174899	NP_777559	Q8NEA4	FBX36_HUMAN	F-box protein 36	32										ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0179)|Lung NSC(271;0.0804)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;7.56e-14)|all cancers(144;7.74e-11)|Lung(119;0.00488)|LUSC - Lung squamous cell carcinoma(224;0.008)		CACCCGGTCTCAGGCAAGTGC	0.612													0	0	0	0.010729	0	12	34										G	230787323	C	G	230787323	3	3	16	1	0	0	0	0	1	0	0	0	5745	827	29	1	96	1	FBXO36	2	230787323	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2649621	230787323	12412050	139	3862										
SP110	3431	broad.mit.edu	37	chr2	231035336	231035336	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaagcaggaaatgctctttaCcttgtaaaatgttttatggt	9	5	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:231035336C>T	uc002vqh.3	-	17	2196	c.1956_splice	c.e17+1	p.K652_splice	SP110_uc002vqg.3_Splice_Site_p.K676_splice	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a						interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		ATGCTCTTTACCTTGTAAAAT	0.443													0	0	0	0.010729	0	10	25										T	231035336	C	T	231035336	5	4	16	1	0	0	0	0	0	0	1	0	14961	521	18	2	120	2	SP110	2	231035336	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	248013	231035336	12164037	140	3863										
SP140L	93349	broad.mit.edu	37	chr2	231222548	231222548	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cggaagaccaggatgtagatGagggacttgtctatgacact	13	7	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:231222548G>A	uc010fxm.1	+	3	227	c.136G>A	c.(136-138)GAG>AAG	p.E46K	SP140_uc010zma.1_RNA|SP140L_uc010fxn.1_5'UTR	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	46	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						GGATGTAGATGAGGGACTTGT	0.398													0	0	0	0.009535	0	27	188										A	231222548	G	A	231222548	3	1	16	1	0	0	0	0	1	0	0	0	14963	1291	45	1	146	1	SP140L	2	231222548	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	187212	231222548	11976825	141	3864										
PSMD1	5707	broad.mit.edu	37	chr2	231936987	231936987	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acaacctcctgatggcatatCagatttgttttgatttgtat	7	7	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:231936987C>T	uc002vrn.1	+	7	870	c.739C>T	c.(739-741)CAG>TAG	p.Q247*	PSMD1_uc002vrm.1_Nonsense_Mutation_p.Q247*|PSMD1_uc010fxu.1_Nonsense_Mutation_p.Q111*	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	247					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	GATGGCATATCAGATTTGTTT	0.403													0	0	0	0.01441	0	47	117										T	231936987	C	T	231936987	4	4	16	1	0	0	0	0	0	1	0	0	12692	827	29	1	765	1	PSMD1	2	231936987	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	714439	231936987	11262386	142	3865										
GIGYF2	26058	broad.mit.edu	37	chr2	233626135	233626135	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acgttttgaaaaaccaggacGaaaagatgtaggtaaggttc	11	5	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:233626135G>A	uc002vti.3	+	10	858	c.521G>A	c.(520-522)CGA>CAA	p.R174Q	GIGYF2_uc010zmj.1_Missense_Mutation_p.R174Q|GIGYF2_uc002vtg.2_Missense_Mutation_p.R174Q|GIGYF2_uc002vtj.3_Missense_Mutation_p.R174Q|GIGYF2_uc002vtk.3_Missense_Mutation_p.R174Q|GIGYF2_uc002vth.3_Missense_Mutation_p.R174Q|GIGYF2_uc010zmk.1_RNA	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	174	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AAACCAGGACGAAAAGATGTA	0.378													0	0	0	0.00499	0	14	28										A	233626135	G	A	233626135	3	1	16	1	0	0	0	0	1	0	0	0	6378	1058	37	1	543	1	GIGYF2	2	233626135	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1689148	233626135	9573238	143	3866										
GIGYF2	26058	broad.mit.edu	37	chr2	233651882	233651882	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agaccaaattttgaggaaggTggaccaacatcagtagggag	13	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:233651882T>G	uc002vti.3	+	11	892	c.555T>G	c.(553-555)GGT>GGG	p.G185G	GIGYF2_uc010zmj.1_Silent_p.G185G|GIGYF2_uc002vtg.2_Silent_p.G185G|GIGYF2_uc002vtj.3_Silent_p.G207G|GIGYF2_uc002vtk.3_Silent_p.G185G|GIGYF2_uc002vth.3_Silent_p.G185G|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Silent_p.G16G	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	185	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTGAGGAAGGTGGACCAACAT	0.383													0	0	0	0.008291	0	9	41										G	233651882	T	G	233651882	2	3	16	1	0	0	0	0	0	0	0	1	6378	1683	59	5		5	GIGYF2	2	233651882	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	25747	233651882	9547491	144	3867										
GIGYF2	26058	broad.mit.edu	37	chr2	233721509	233721509	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttttttttctgcaggattttCagtcaatgcatcatcggagc	8	8	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:233721509C>T	uc002vti.3	+	31	4176	c.3839C>T	c.(3838-3840)TCA>TTA	p.S1280L	GIGYF2_uc002vtj.3_Missense_Mutation_p.S1301L|GIGYF2_uc002vtk.3_Missense_Mutation_p.S1280L|GIGYF2_uc002vth.3_Missense_Mutation_p.S1274L|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc002vtq.3_Missense_Mutation_p.S613L	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1280					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCAGGATTTTCAGTCAATGCA	0.502													0	0	0	0.003271	0	32	66										T	233721509	C	T	233721509	3	4	16	1	0	0	0	0	1	0	0	0	6378	838	29	1	4015	1	GIGYF2	2	233721509	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	69627	233721509	9477864	145	3868										
COL6A3	1293	broad.mit.edu	37	chr2	238277474	238277475	+	Frame_Shift_Del	DEL	CA	CA	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttccacccaggaccaggacCaggtgttggggcaccccgtc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:238277474_238277475delCA	uc002vwl.2	-	10	4916_4917	c.4631_4632delTG	c.(4630-4632)CTGfs	p.L1544fs	COL6A3_uc002vwo.2_Frame_Shift_Del_p.L1338fs|COL6A3_uc010znj.1_Frame_Shift_Del_p.L937fs	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1544	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGACCAGGACCAGGTGTTGGGG	0.569																		23	125	---	---								-	238277475	CA	-	238277474	7	5	16	1	0	1	0	1	0	0	0	0	3701	581	21	0	5041	0	COL6A3	2	238277474	Frame_Shift_Del	DEL	CA	TCGA-BT-A2LB-01A-11D-A18F-08	4555965	238277474	4921899	146	3869										
CNTN6	27255	broad.mit.edu	37	chr3	1445006	1445006	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttttatattttgcaggtttGagttccagaggaattcaatt	8	4	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:1445006G>C	uc003boz.2	+	23	3258	c.2991G>C	c.(2989-2991)TTG>TTC	p.L997F	CNTN6_uc011asj.1_Missense_Mutation_p.L925F|CNTN6_uc003bpa.2_Missense_Mutation_p.L997F	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	997					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTGCAGGTTTGAGTTCCAGAG	0.303													0	0	0	0.010729	0	12	40										C	1445006	G	C	1445006	3	2	16	1	0	0	0	0	1	0	0	0	3645	1281	45	1	3077	1	CNTN6	3	1445006	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		1445006	196577424	147	3870										
CRBN	51185	broad.mit.edu	37	chr3	3194143	3194143	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caccaccataatattacccaGgaaaccagctgtgttctgta	6	12	1	0	rs146272907		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:3194143G>C	uc003bpq.2	-	10	1164	c.1145C>G	c.(1144-1146)CCT>CGT	p.P382R	CRBN_uc003bpr.2_Missense_Mutation_p.P381R|CRBN_uc010hbw.2_Intron	NM_016302	NP_057386	Q96SW2	CRBN_HUMAN	cereblon	382	Thalidomide-binding.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			ovary(1)	1				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		ATATTACCCAGGAAACCAGCT	0.393													0	0	0	0.014323	0	22	37										C	3194143	G	C	3194143	3	2	16	1	0	0	0	0	1	0	0	0	3851	1000	35	4	191	4	CRBN	3	3194143	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1749137	3194143	194828287	148	3871										
ITPR1	3708	broad.mit.edu	37	chr3	4818947	4818947	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctgtgtgtgtctttgctcaGaactgcatagccacccatga	9	11	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:4818947G>A	uc003bqa.2	+	45	6385	c.6037_splice	c.e45-1	p.N2013_splice	ITPR1_uc010hca.1_Splice_Site_p.N1998_splice|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Splice_Site_p.N983_splice	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1						activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCTTTGCTCAGAACTGCATAG	0.448													0	0	0	0.004672	0	3	4										A	4818947	G	A	4818947	5	1	16	1	0	0	0	0	0	0	1	0	7920	956	33	1	6362	1	ITPR1	3	4818947	Splice_Site	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1624804	4818947	193203483	149	3872										
ATP2B2	491	broad.mit.edu	37	chr3	10420033	10420033	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcttcctgtcgtcagcgtcGccgccctcggcactcttgag	10	16	3	1	rs147871544		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:10420033G>A	uc003bvt.2	-	10	1543	c.1104C>T	c.(1102-1104)GGC>GGT	p.G368G	ATP2B2_uc003bvv.2_Silent_p.G323G|ATP2B2_uc003bvw.2_Silent_p.G323G|ATP2B2_uc010hdo.2_Silent_p.G73G	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	368	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGTCAGCGTCGCCGCCCTCGG	0.627													0	0	0	0.01441	0	50	72										A	10420033	G	A	10420033	2	1	16	1	0	0	0	0	0	0	0	1	1140	1074	38	2		2	ATP2B2	3	10420033	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5601086	10420033	187602397	150	3873										
TIMP4	7079	broad.mit.edu	37	chr3	12195844	12195844	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tacttggcagccacagttcaGatggtagtgatgattcagac	11	8	2	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:12195844G>A	uc003bwo.2	-	4	767	c.460C>T	c.(460-462)CTG>TTG	p.L154L	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	154	NTR.						metal ion binding|metalloendopeptidase inhibitor activity				0						CCACAGTTCAGATGGTAGTGA	0.473													0	0	0	0.01441	0	72	157										A	12195844	G	A	12195844	2	1	16	1	0	0	0	0	0	0	0	1	15917	933	33	1		1	TIMP4	3	12195844	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1775811	12195844	185826586	151	3874										
KCNH8	131096	broad.mit.edu	37	chr3	19436626	19436626	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcatcttctaaagacagtgCgcctcttgcgtcttttgcgt	9	11	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:19436626C>T	uc003cbk.1	+	7	1195	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C	KCNH8_uc011awe.1_Missense_Mutation_p.R334C|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	334	Helical; Voltage-sensor; Name=Segment S4; (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AAAGACAGTGCGCCTCTTGCG	0.478													0	0	0	0.01441	0	45	103										T	19436626	C	T	19436626	3	4	16	1	0	0	0	0	1	0	0	0	8038	768	27	2	1026	2	KCNH8	3	19436626	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7240782	19436626	178585804	152	3875										
CMTM8	152189	broad.mit.edu	37	chr3	32280541	32280541	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgcagagaacttctccaccaGcagcagcagcttcgcctacg	9	16	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:32280541G>A	uc003cex.2	+	1	371	c.77G>A	c.(76-78)AGC>AAC	p.S26N	CMTM8_uc010hfu.2_Missense_Mutation_p.S26N	NM_178868	NP_849199	Q8IZV2	CKLF8_HUMAN	CKLF-like MARVEL transmembrane domain containing	26					chemotaxis	extracellular space|integral to membrane	cytokine activity				0						TTCTCCACCAGCAGCAGCAGC	0.706													0	0	0	0.001168	0	5	6										A	32280541	G	A	32280541	3	1	16	1	0	0	0	0	1	0	0	0	3589	971	34	2	79	2	CMTM8	3	32280541	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	12843915	32280541	165741889	153	3876										
UBP1	7342	broad.mit.edu	37	chr3	33434926	33434926	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctgaggcaatcatttcttCcaagtagattgcatgataaa	7	7	3	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:33434926C>T	uc003cfq.3	-	14	1941	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	FBXL2_uc011axq.1_Intron|FBXL2_uc011axr.1_Intron|UBP1_uc003cfr.3_Missense_Mutation_p.E435K|UBP1_uc010hga.2_Missense_Mutation_p.E471K	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	471					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						ATCATTTCTTCCAAGTAGATT	0.368													0	0	0	0.013537	0	12	32										T	33434926	C	T	33434926	3	4	16	1	0	0	0	0	1	0	0	0	16892	864	30	1	223	1	UBP1	3	33434926	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1154385	33434926	164587504	154	3877										
CLASP2	23122	broad.mit.edu	37	chr3	33614729	33614729	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgtctgcctcatatatgtagGaatactaccatttcgagaac	7	10	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:33614729G>A	uc003cfu.2	-	25	2926	c.2572C>T	c.(2572-2574)CCT>TCT	p.P858S	CLASP2_uc003cfs.2_Missense_Mutation_p.P66S|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.P459S	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	867										ovary(3)|central_nervous_system(1)	4						ATATATGTAGGAATACTACCA	0.433													0	0	0	0.01441	0	70	135										A	33614729	G	A	33614729	3	1	16	1	0	0	0	0	1	0	0	0	3455	1174	41	1	2004	1	CLASP2	3	33614729	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	179803	33614729	164407701	155	3878										
DLEC1	9940	broad.mit.edu	37	chr3	38157986	38157986	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctatgttccagaagacaaggAagaccggctggtggagctgc	14	9	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:38157986A>G	uc003cho.1	+	28	3920	c.3899A>G	c.(3898-3900)GAA>GGA	p.E1300G	DLEC1_uc003chp.1_Missense_Mutation_p.E1300G|DLEC1_uc010hgv.1_Missense_Mutation_p.E1303G|DLEC1_uc003chr.1_Missense_Mutation_p.E371G|DLEC1_uc010hgx.1_RNA|DLEC1_uc003chs.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1300					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GAAGACAAGGAAGACCGGCTG	0.607													0	0	0	0.004656	0	18	50										G	38157986	A	G	38157986	3	3	16	1	0	0	0	0	1	0	0	0	4552	246	9	5	4009	5	DLEC1	3	38157986	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	4543257	38157986	159864444	156	3879										
TTC21A	199223	broad.mit.edu	37	chr3	39166997	39166997	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcctggtctgcattgctaagGagtacttgctcttctgcccc	9	13	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:39166997G>A	uc003cjc.2	+	11	1567	c.1390G>A	c.(1390-1392)GAG>AAG	p.E464K	TTC21A_uc003cje.2_Missense_Mutation_p.E464K|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.E415K	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	464							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CATTGCTAAGGAGTACTTGCT	0.552													0	0	0	0.013726	0	28	96										A	39166997	G	A	39166997	3	1	16	1	0	0	0	0	1	0	0	0	16684	1175	41	1	1432	1	TTC21A	3	39166997	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1009011	39166997	158855433	157	3880										
ULK4	54986	broad.mit.edu	37	chr3	41831325	41831325	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	taggagaatggcgagtgattCtacacaaggcctacaaagac	11	8	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:41831325C>T	uc003ckv.3	-	21	2222	c.2021G>A	c.(2020-2022)AGA>AAA	p.R674K	ULK4_uc003ckw.2_Missense_Mutation_p.R674K	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	674							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GCGAGTGATTCTACACAAGGC	0.463													0	0	0	0.014323	0	20	43										T	41831325	C	T	41831325	3	4	16	1	0	0	0	0	1	0	0	0	16975	913	32	1	1874	1	ULK4	3	41831325	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2664328	41831325	156191105	158	3881										
ULK4	54986	broad.mit.edu	37	chr3	41860995	41860995	+	Frame_Shift_Del	DEL	C	C	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctagggttcttttttttttCttcctaaaatgaagtgggaa							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:41860995delC	uc003ckv.3	-	19	1969	c.1768delG	c.(1768-1770)GAAfs	p.E590fs	ULK4_uc003ckw.2_Frame_Shift_Del_p.E590fs	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	590							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TTTTTTTTTTCTTCCTAAAAT	0.438																		24	82	---	---								-	41860995	C	-	41860995	7	5	16	1	0	1	0	1	0	0	0	0	16975	922	32	0	2135	0	ULK4	3	41860995	Frame_Shift_Del	DEL	C	TCGA-BT-A2LB-01A-11D-A18F-08	29670	41860995	156161435	159	3882										
DHX30	22907	broad.mit.edu	37	chr3	47883135	47883135	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctttgagatgacagatgacGacagtgccattagggctctg	12	9	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:47883135G>A	uc003cru.2	+	8	1123	c.697G>A	c.(697-699)GAC>AAC	p.D233N	DHX30_uc003crs.2_Missense_Mutation_p.D194N|DHX30_uc003crt.2_Missense_Mutation_p.D194N|DHX30_uc010hjr.1_Missense_Mutation_p.D261N	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	233						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GACAGATGACGACAGTGCCAT	0.493													0	0	0	0.00632	0	30	54										A	47883135	G	A	47883135	3	1	16	1	0	0	0	0	1	0	0	0	4504	1058	37	1	730	1	DHX30	3	47883135	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6022140	47883135	150139295	160	3883										
RBM6	10180	broad.mit.edu	37	chr3	50012766	50012766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atttttgcagattcttaatgCttttcggactcctgatggca	8	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:50012766C>T	uc003cyc.2	+	5	1557	c.1424C>T	c.(1423-1425)GCT>GTT	p.A475V	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_5'UTR|RBM6_uc003cyd.2_5'UTR|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	475	RRM.				RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		ATTCTTAATGCTTTTCGGACT	0.358													0	0	0	0.014323	0	22	59										T	50012766	C	T	50012766	3	4	16	1	0	0	0	0	1	0	0	0	13144	797	28	2	1438	2	RBM6	3	50012766	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2129631	50012766	148009664	161	3884										
RBM5	10181	broad.mit.edu	37	chr3	50145531	50145531	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggtgaaggaggcagtgttgActacagttatctgcaaccag	13	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:50145531A>G	uc003cyg.2	+	13	1218	c.1070A>G	c.(1069-1071)GAC>GGC	p.D357G	RBM5_uc011bdj.1_Missense_Mutation_p.D301G|RBM5_uc011bdk.1_Missense_Mutation_p.D185G	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	357	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGCAGTGTTGACTACAGTTAT	0.403													0	0	0	0.012319	0	19	28										G	50145531	A	G	50145531	3	3	16	1	0	0	0	0	1	0	0	0	13143	275	10	5	1116	5	RBM5	3	50145531	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	132765	50145531	147876899	162	3885										
MAPKAPK3	7867	broad.mit.edu	37	chr3	50685459	50685459	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcagctcctctgcctcacaGggctgcaacaaccagtagct	10	15	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:50685459G>A	uc003day.1	+	13	1727	c.1131G>A	c.(1129-1131)CAG>CAA	p.Q377Q	MAPKAPK3_uc003daz.1_Silent_p.Q377Q|MAPKAPK3_uc003dba.1_Silent_p.Q377Q|MAPKAPK3_uc010hlr.1_Silent_p.Q377Q	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	377					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CTGCCTCACAGGGCTGCAACA	0.572													0	0	0	0.008291	0	11	43										A	50685459	G	A	50685459	2	1	16	1	0	0	0	0	0	0	0	1	9290	991	35	2		2	MAPKAPK3	3	50685459	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	539928	50685459	147336971	163	3886										
VPRBP	9730	broad.mit.edu	37	chr3	51464860	51464860	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaattgcaggcaatagaaaTaagctgcaacaagagttgca	9	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:51464860T>G	uc003dbe.1	-	12	1978	c.1810A>C	c.(1810-1812)ATT>CTT	p.I604L		NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	604					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		GCAATAGAAATAAGCTGCAAC	0.388													0	0	0	0.00278	0	20	35										G	51464860	T	G	51464860	3	3	16	1	0	0	0	0	1	0	0	0	17182	1406	49	5	2765	5	VPRBP	3	51464860	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	779401	51464860	146557570	164	3887										
ITIH1	3697	broad.mit.edu	37	chr3	52812034	52812034	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agcgacaggctgtggacaccGtgagtaagagtcctggcaaa	14	9	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:52812034G>T	uc003dfs.2	+	2	162	c.138_splice	c.e2+1	p.T46_splice	ITIH1_uc010hmn.1_Splice_Site	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1						hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGTGGACACCGTGAGTAAGAG	0.562													1	0	1.22674e-20	0.00874	1.32679e-20	33	71										T	52812034	G	T	52812034	5	4	16	1	0	0	0	0	0	0	1	0	7903	1159	40	4	145	4	ITIH1	3	52812034	Splice_Site	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1347174	52812034	145210396	165	3888										
PDE12	201626	broad.mit.edu	37	chr3	57545080	57545080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggactcttctaaaaggatatGtgttgctaatacccatcttt	7	8	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:57545080G>A	uc003diw.3	+	2	1478	c.1352G>A	c.(1351-1353)TGT>TAT	p.C451Y	PDE12_uc003div.2_Missense_Mutation_p.C451Y	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	451							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		AAAAGGATATGTGTTGCTAAT	0.358													0	0	0	0.001855	0	13	67										A	57545080	G	A	57545080	3	1	16	1	0	0	0	0	1	0	0	0	11632	1377	48	2	1358	2	PDE12	3	57545080	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4733046	57545080	140477350	166	3889										
MAGI1	9223	broad.mit.edu	37	chr3	65346992	65346992	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttggtggtctcaccattgatCtctaaaatttcatcaccaat	5	10	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:65346992C>T	uc003dmn.2	-	22	4042	c.3516G>A	c.(3514-3516)GAG>GAA	p.E1172E	MAGI1_uc003dmm.2_Silent_p.E1200E|MAGI1_uc003dmo.2_Silent_p.E1201E|MAGI1_uc003dmp.2_Silent_p.E1105E	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1201	PDZ 6.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CACCATTGATCTCTAAAATTT	0.348													0	0	0	0.012319	0	21	30										T	65346992	C	T	65346992	2	4	16	1	0	0	0	0	0	0	0	1	9190	912	32	1		1	MAGI1	3	65346992	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7801912	65346992	132675438	167	3890										
SHQ1	55164	broad.mit.edu	37	chr3	72799820	72799820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aatcacttgcctcagagctgGagcaaagtgtctgctgccca	10	12	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:72799820G>A	uc003dpf.2	-	11	1456	c.1349C>T	c.(1348-1350)TCC>TTC	p.S450F	SHQ1_uc010hod.2_Missense_Mutation_p.S361F	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	450	Ser-rich.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		CTCAGAGCTGGAGCAAAGTGT	0.478													0	0	0	0.004482	0	9	6										A	72799820	G	A	72799820	3	1	16	1	0	0	0	0	1	0	0	0	14292	1174	41	1	388	1	SHQ1	3	72799820	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7452828	72799820	125222610	168	3891										
SHQ1	55164	broad.mit.edu	37	chr3	72897392	72897392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaacttgaagtcagacccctCgaagtagacgtcgaactcgg	11	11	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:72897392C>T	uc003dpf.2	-	1	207	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SHQ1_uc010hod.2_5'UTR	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	34	CS.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		TCAGACCCCTCGAAGTAGACG	0.592													0	0	0	0.01441	0	73	139										T	72897392	C	T	72897392	3	4	16	1	0	0	0	0	1	0	0	0	14292	893	31	1	1677	1	SHQ1	3	72897392	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	97572	72897392	125125038	169	3892										
CNTN3	5067	broad.mit.edu	37	chr3	74350557	74350557	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaaaacactaacctgcctctTcagttcttactttttctgag	4	11	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:74350557T>C	uc003dpm.1	-	15	2167	c.2087A>G	c.(2086-2088)GAA>GGA	p.E696G		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	696					cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACCTGCCTCTTCAGTTCTTAC	0.433													0	0	0	0.014323	0	19	62										C	74350557	T	C	74350557	3	2	16	1	0	0	0	0	1	0	0	0	3642	1783	62	5	1031	5	CNTN3	3	74350557	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1453165	74350557	123671873	170	3893										
CNTN3	5067	broad.mit.edu	37	chr3	74350587	74350587	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctttttctgagggtaaacttGgttctccacctccaattttg	7	10	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:74350587G>T	uc003dpm.1	-	15	2137	c.2057C>A	c.(2056-2058)CCA>CAA	p.P686Q		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	686	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GGGTAAACTTGGTTCTCCACC	0.408													1	0	1.33834e-09	0.007413	1.419e-09	17	75										T	74350587	G	T	74350587	3	4	16	1	0	0	0	0	1	0	0	0	3642	1348	47	4	1061	4	CNTN3	3	74350587	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	30	74350587	123671843	171	3894										
EPHA6	285220	broad.mit.edu	37	chr3	96706689	96706689	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaagggttgattcctcctcTttggttgaagtacggggttc	12	9	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:96706689T>C	uc010how.1	+	3	1009	c.966T>C	c.(964-966)TCT>TCC	p.S322S	EPHA6_uc003drp.1_Silent_p.S322S	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	227	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						ATTCCTCCTCTTTGGTTGAAG	0.473													0	0	0	0.01441	0	56	128										C	96706689	T	C	96706689	2	2	16	1	0	0	0	0	0	0	0	1	5171	1596	56	5		5	EPHA6	3	96706689	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	22356102	96706689	101315741	172	3895										
MINA	84864	broad.mit.edu	37	chr3	97686358	97686359	+	In_Frame_Ins	INS	-	-	CTGCTT													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	taaagctgaaggccccccagINSctgcttctaacttcatctgc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:97686358_97686359insCTGCTT	uc003drz.1	-	2	585_586	c.79_80insAAGCAG	c.(79-81)GCT>GAAGCAGCT	p.26_27insEA	MINA_uc003dsa.1_In_Frame_Ins_p.26_27insEA|MINA_uc003dsb.1_In_Frame_Ins_p.26_27insEA|MINA_uc003dsc.1_In_Frame_Ins_p.26_27insEA|MINA_uc010hpa.1_RNA|MINA_uc010hpb.1_Intron	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	26_27					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						AGGCCCCCCAGCTGCTTCTAAC	0.48																		9	73	---	---								CTGCTT	97686359	-	CTGCTT	97686358	7	5	16	1	0	1	1	0	0	0	0	0	9586	971	34	0	1353	0	MINA	3	97686358	In_Frame_Ins	INS	-	TCGA-BT-A2LB-01A-11D-A18F-08	979669	97686358	100336072	173	3896										
MORC1	27136	broad.mit.edu	37	chr3	108690187	108690187	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	accagcttacctcacaacttAatgcaggttcttccaattct	4	13	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:108690187A>G	uc003dxl.2	-	25	2627	c.2540T>C	c.(2539-2541)TTA>TCA	p.L847S	MORC1_uc011bhn.1_Missense_Mutation_p.L826S	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	847					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTCACAACTTAATGCAGGTTC	0.383													0	0	0	0.008361	0	28	76										G	108690187	A	G	108690187	3	3	16	1	0	0	0	0	1	0	0	0	9701	372	13	5	430	5	MORC1	3	108690187	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	11003829	108690187	89332243	174	3897										
TMPRSS7	344805	broad.mit.edu	37	chr3	111785291	111785291	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcaggcagcatggccctctCatctgtgatggcttcaggga	12	11	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:111785291C>T	uc010hqb.2	+	11	1400	c.1230C>T	c.(1228-1230)CTC>CTT	p.L410L	TMPRSS7_uc011bhr.1_Silent_p.L265L	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	536	Extracellular (Potential).|LDL-receptor class A 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						ATGGCCCTCTCATCTGTGATG	0.507													0	0	0	0.00623	0	32	232										T	111785291	C	T	111785291	2	4	16	1	0	0	0	0	0	0	0	1	16249	813	29	1		1	TMPRSS7	3	111785291	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3095104	111785291	86237139	175	3898										
TMPRSS7	344805	broad.mit.edu	37	chr3	111794272	111794272	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccactttgttggatctgccTactgtggtgcctcagtcatc	9	12	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:111794272T>C	uc010hqb.2	+	13	1680	c.1510T>C	c.(1510-1512)TAC>CAC	p.Y504H	TMPRSS7_uc011bhr.1_Missense_Mutation_p.Y359H	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	630	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						TGGATCTGCCTACTGTGGTGC	0.582													0	0	0	0.01441	0	63	489										C	111794272	T	C	111794272	3	2	16	1	0	0	0	0	1	0	0	0	16249	1522	53	5	1556	5	TMPRSS7	3	111794272	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	8981	111794272	86228158	176	3899										
BOC	91653	broad.mit.edu	37	chr3	113003353	113003353	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	catgaataggggctgcccctCggctgcagtgggctacccgg	15	13	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:113003353C>T	uc003dzx.2	+	17	3446	c.2825C>T	c.(2824-2826)TCG>TTG	p.S942L	BOC_uc003dzy.2_Missense_Mutation_p.S942L|BOC_uc003dzz.2_Missense_Mutation_p.S943L|BOC_uc003eab.2_Missense_Mutation_p.S643L|BOC_uc003eac.2_Missense_Mutation_p.S257L	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	942	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GGCTGCCCCTCGGCTGCAGTG	0.647													0	0	0	0.009718	0	43	37										T	113003353	C	T	113003353	3	4	16	1	0	0	0	0	1	0	0	0	1481	893	31	1	2883	1	BOC	3	113003353	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1209081	113003353	85019077	177	3900										
GOLGB1	2804	broad.mit.edu	37	chr3	121411211	121411211	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttttgttccttacatttttCtaaagagttacttaaatcag	4	6	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:121411211C>T	uc003eei.3	-	14	7111	c.6985G>A	c.(6985-6987)GAA>AAA	p.E2329K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E2334K|GOLGB1_uc003eej.3_Missense_Mutation_p.E2295K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2329	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTACATTTTTCTAAAGAGTTA	0.373													0	0	0	0.010818	0	29	156										T	121411211	C	T	121411211	3	4	16	1	0	0	0	0	1	0	0	0	6565	922	32	1	2830	1	GOLGB1	3	121411211	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8407858	121411211	76611219	178	3901										
GOLGB1	2804	broad.mit.edu	37	chr3	121415253	121415253	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caatttctgctgcaggctttCggcatggacttcagcttcat	9	11	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:121415253C>T	uc003eei.3	-	13	4228	c.4102G>A	c.(4102-4104)GAA>AAA	p.E1368K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1373K|GOLGB1_uc003eej.3_Missense_Mutation_p.E1334K|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1254K|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1332K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1368	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGCAGGCTTTCGGCATGGACT	0.398													0	0	0	0.01441	0	288	141										T	121415253	C	T	121415253	3	4	16	1	0	0	0	0	1	0	0	0	6565	893	31	1	5717	1	GOLGB1	3	121415253	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4042	121415253	76607177	179	3902										
ITGB5	3693	broad.mit.edu	37	chr3	124487931	124487931	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctggttgtcaggtttcccaGagtggagcagcaggcactcg	14	10	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:124487931G>A	uc003eho.2	-	12	2243	c.1946C>T	c.(1945-1947)TCT>TTT	p.S649F	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	649	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		AGGTTTCCCAGAGTGGAGCAG	0.557													0	0	0	0.01441	0	138	46										A	124487931	G	A	124487931	3	1	16	1	0	0	0	0	1	0	0	0	7898	942	33	1	469	1	ITGB5	3	124487931	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3072678	124487931	73534499	180	3903										
ZNF148	7707	broad.mit.edu	37	chr3	124952081	124952081	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcttgtgttacagaaggctGagaagctatggtacccacat	11	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:124952081G>A	uc003ehx.3	-	9	1975	c.1489C>T	c.(1489-1491)CAG>TAG	p.Q497*	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Nonsense_Mutation_p.Q497*|ZNF148_uc010hsa.2_Nonsense_Mutation_p.Q497*|ZNF148_uc003eia.3_Nonsense_Mutation_p.Q497*|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	497					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						ACAGAAGGCTGAGAAGCTATG	0.438													0	0	0	0.01441	0	192	83										A	124952081	G	A	124952081	4	1	16	1	0	0	0	0	0	1	0	0	17731	1299	45	1	899	1	ZNF148	3	124952081	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	464150	124952081	73070349	181	3904										
PLXNA1	5361	broad.mit.edu	37	chr3	126724992	126724992	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagtttgcgtctgtggacttCgtcttctacaactgcagcgt	10	10	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:126724992C>T	uc003ejg.2	+	7	1903	c.1899C>T	c.(1897-1899)TTC>TTT	p.F633F		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	656	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CTGTGGACTTCGTCTTCTACA	0.607													0	0	0	0.010504	0	22	176										T	126724992	C	T	126724992	2	4	16	1	0	0	0	0	0	0	0	1	12119	883	31	1		1	PLXNA1	3	126724992	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1772911	126724992	71297438	182	3905										
PLXNA1	5361	broad.mit.edu	37	chr3	126735421	126735421	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agagccctggcagcgctcccAtcatcatcaacatcaaccgc	7	17	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:126735421A>G	uc003ejg.2	+	15	3011	c.3007A>G	c.(3007-3009)ATC>GTC	p.I1003V		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1026	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGCGCTCCCATCATCATCAA	0.632													0	0	0	0.006122	0	15	216										G	126735421	A	G	126735421	3	3	16	1	0	0	0	0	1	0	0	0	12119	217	8	5	3134	5	PLXNA1	3	126735421	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	10429	126735421	71287009	183	3906										
EEFSEC	60678	broad.mit.edu	37	chr3	128060247	128060247	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgcggccctcatctctgtgGaaaagataccgtatttccgg	10	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:128060247G>A	uc003eki.2	+	5	996	c.958G>A	c.(958-960)GAA>AAA	p.E320K	EEFSEC_uc003ekj.2_Missense_Mutation_p.E265K	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	320						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						CATCTCTGTGGAAAAGATACC	0.582													0	0	0	0.01441	0	56	254										A	128060247	G	A	128060247	3	1	16	1	0	0	0	0	1	0	0	0	4931	1175	41	1	976	1	EEFSEC	3	128060247	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1324826	128060247	69962183	184	3907										
PIK3R4	30849	broad.mit.edu	37	chr3	130405056	130405056	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacttgaaagttagcttaccAatgcagagccagcattggtg	11	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:130405056A>G	uc003enj.2	-	15	4055	c.3474T>C	c.(3472-3474)ATT>ATC	p.I1158I		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1158	WD 4.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTAGCTTACCAATGCAGAGCC	0.428													0	0	0	0.005443	0	25	25										G	130405056	A	G	130405056	2	3	16	1	0	0	0	0	0	0	0	1	11921	144	5	5		5	PIK3R4	3	130405056	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2344809	130405056	67617374	185	3908										
ACPP	55	broad.mit.edu	37	chr3	132071660	132071660	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acttgacggaattgtactttGagaaggggtaagtgactaag	13	4	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:132071660G>A	uc010htp.2	+	9	1051	c.961G>A	c.(961-963)GAG>AAG	p.E321K	ACPP_uc003eon.3_Missense_Mutation_p.E288K|ACPP_uc003eop.3_Missense_Mutation_p.E321K	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	321						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						ATTGTACTTTGAGAAGGGGTA	0.433													0	0	0	0.001855	0	14	29										A	132071660	G	A	132071660	3	1	16	1	0	0	0	0	1	0	0	0	167	1291	45	1	995	1	ACPP	3	132071660	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1666604	132071660	65950770	186	3909										
CCRL1	51554	broad.mit.edu	37	chr3	132319410	132319410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tagttttcgtcattggacttGcaggcaattccatggtagtg	11	7	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:132319410G>A	uc003eow.2	+	2	252	c.169G>A	c.(169-171)GCA>ACA	p.A57T	ACAD11_uc003eov.3_Intron|ACAD11_uc011blr.1_Intron|CCRL1_uc003eox.2_Missense_Mutation_p.A57T	NM_016557	NP_057641	Q9NPB9	CCRL1_HUMAN	chemokine (C-C motif) receptor-like 1	57	Helical; Name=1; (Potential).				chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity				0						CATTGGACTTGCAGGCAATTC	0.383													0	0	0	0.003954	0	20	23										A	132319410	G	A	132319410	3	1	16	1	0	0	0	0	1	0	0	0	2949	1319	46	2	171	2	CCRL1	3	132319410	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	247750	132319410	65703020	187	3910										
TOPBP1	11073	broad.mit.edu	37	chr3	133339155	133339155	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttatctcctgtaactgcttcTgaaagttctctctcatctct	4	12	5	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:133339155T>G	uc003eps.2	-	20	3347	c.3215A>C	c.(3214-3216)CAG>CCG	p.Q1072P	TOPBP1_uc003ept.1_Missense_Mutation_p.Q76P	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1072					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						TAACTGCTTCTGAAAGTTCTC	0.398								Other_conserved_DNA_damage_response_genes					0	0	0	0.004289	0	32	19										G	133339155	T	G	133339155	3	3	16	1	0	0	0	0	1	0	0	0	16366	1580	55	5	1389	5	TOPBP1	3	133339155	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1019745	133339155	64683275	188	3911										
NCK1	4690	broad.mit.edu	37	chr3	136667120	136667120	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccaaatgatttctcagtatCactaaaagcacaagggaaaa	7	8	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:136667120C>T	uc003erh.2	+	4	1066	c.959C>T	c.(958-960)TCA>TTA	p.S320L	NCK1_uc011bme.1_Missense_Mutation_p.S256L	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	320	SH2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						TTCTCAGTATCACTAAAAGCA	0.308													0	0	0	0.013537	0	10	18										T	136667120	C	T	136667120	3	4	16	1	0	0	0	0	1	0	0	0	10219	838	29	1	969	1	NCK1	3	136667120	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3327965	136667120	61355310	189	3912										
RAP2B	5912	broad.mit.edu	37	chr3	152880938	152880938	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcggccaaaaacaaagcctcGgtagacgagctatttgccga	10	11	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:152880938G>A	uc003ezr.2	+	1	910	c.456G>A	c.(454-456)TCG>TCA	p.S152S		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	152					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			ACAAAGCCTCGGTAGACGAGC	0.642													0	0	0	0.000602	0	5	9										A	152880938	G	A	152880938	2	1	16	1	0	0	0	0	0	0	0	1	13041	1103	39	2		2	RAP2B	3	152880938	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	16213818	152880938	45141492	190	3913										
RPL22L1	200916	broad.mit.edu	37	chr3	170584195	170584195	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctccgactctgattcatcttCatcttgactaatctggaagt	6	11	6	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:170584195C>T	uc003fhc.3	-	4	432	c.343G>A	c.(343-345)GAA>AAA	p.E115K	RPL22L1_uc003fhb.3_RNA	NM_001099645	NP_001093115	Q6P5R6	RL22L_HUMAN	ribosomal protein L22-like 1	115					translation	ribosome	structural constituent of ribosome				0	all_cancers(22;1.96e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.137)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GATTCATCTTCATCTTGACTA	0.393													0	0	0	0.000602	0	4	22										T	170584195	C	T	170584195	3	4	16	1	0	0	0	0	1	0	0	0	13569	835	29	1	29	1	RPL22L1	3	170584195	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	17703257	170584195	27438235	191	3914										
SLC2A2	6514	broad.mit.edu	37	chr3	170727792	170727792	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccagcaattataagtatatGagatggtcccaattttgaaa	7	6	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:170727792G>C	uc003fhe.1	-	4	760	c.451C>G	c.(451-453)CAT>GAT	p.H151D	SLC2A2_uc003fhf.1_Intron|SLC2A2_uc011bpu.1_Missense_Mutation_p.H24D	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	151	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			ATAAGTATATGAGATGGTCCC	0.289													0	0	0	0.001855	0	14	24										C	170727792	G	C	170727792	3	2	16	1	0	0	0	0	1	0	0	0	14544	1290	45	1	1155	1	SLC2A2	3	170727792	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	143597	170727792	27294638	192	3915										
NCEH1	57552	broad.mit.edu	37	chr3	172365740	172365740	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcgtttcagtggctcttcGggcttcggagggccttcaaa	13	11	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:172365740G>C	uc011bpx.1	-	2	537	c.399C>G	c.(397-399)CCC>CCG	p.P133P	NCEH1_uc003fig.2_Silent_p.P133P|NCEH1_uc011bpw.1_5'UTR|NCEH1_uc011bpy.1_Intron	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	101	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						GTGGCTCTTCGGGCTTCGGAG	0.532													0	0	0	0.00499	0	16	46										C	172365740	G	C	172365740	2	2	16	1	0	0	0	0	0	0	0	1	10215	1103	39	4		4	NCEH1	3	172365740	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1637948	172365740	25656690	193	3916										
GNB4	59345	broad.mit.edu	37	chr3	179119064	179119064	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagccatgccatcatcagtTacacctaagcagctcacacg	6	15	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:179119064T>C	uc003fjv.3	-	10	1240	c.960A>G	c.(958-960)GTA>GTG	p.V320V	GNB4_uc003fju.3_3'UTR	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	320	WD 7.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			CATCATCAGTTACACCTAAGC	0.383													0	0	0	0.014323	0	20	29										C	179119064	T	C	179119064	2	2	16	1	0	0	0	0	0	0	0	1	6520	1741	61	5		5	GNB4	3	179119064	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	6753324	179119064	18903366	194	3917										
FXR1	8087	broad.mit.edu	37	chr3	180630521	180630521	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggctctaacggggctttctaCaaggtactgaccgttttgcc	11	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:180630521C>T	uc003fkq.2	+	1	70	c.48C>T	c.(46-48)TAC>TAT	p.Y16Y	FXR1_uc003fkp.2_5'UTR|FXR1_uc003fkr.2_Silent_p.Y16Y|FXR1_uc011bqj.1_5'UTR|FXR1_uc003fks.2_5'UTR|FXR1_uc011bqk.1_Silent_p.Y16Y|FXR1_uc011bql.1_5'Flank	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	16					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GGGCTTTCTACAAGGTACTGA	0.552											OREG0015934	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	57	113										T	180630521	C	T	180630521	2	4	16	1	0	0	0	0	0	0	0	1	6115	489	17	2		2	FXR1	3	180630521	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1511457	180630521	17391909	195	3918										
KLHL6	89857	broad.mit.edu	37	chr3	183209963	183209963	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtggctgagctgggtcaccaGgcaccagctgtcttccagcg	14	13	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:183209963G>A	uc003flr.2	-	7	1676	c.1618C>T	c.(1618-1620)CTG>TTG	p.L540L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	540	Kelch 5.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TGGGTCACCAGGCACCAGCTG	0.632													0	0	0	0.00333	0	26	33										A	183209963	G	A	183209963	2	1	16	1	0	0	0	0	0	0	0	1	8393	991	35	2		2	KLHL6	3	183209963	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2579442	183209963	14812467	196	3919										
ABCC5	10057	broad.mit.edu	37	chr3	183665178	183665178	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcccgtgcataagaacgatCatcagccccgtggtggtgat	12	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:183665178C>T	uc003fmg.2	-	23	3513	c.3348G>A	c.(3346-3348)ATG>ATA	p.M1116I	ABCC5_uc011bqt.1_Missense_Mutation_p.M644I|ABCC5_uc010hxl.2_Missense_Mutation_p.M1073I	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1116	Helical; (Potential).|ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAAGAACGATCATCAGCCCCG	0.552													0	0	0	0.00499	0	16	23										T	183665178	C	T	183665178	3	4	16	1	0	0	0	0	1	0	0	0	56	826	29	1	997	1	ABCC5	3	183665178	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	455215	183665178	14357252	197	3920										
CHRD	8646	broad.mit.edu	37	chr3	184099561	184099561	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggtggcacgagcccgagtctCgctgctgcgctctagcctcc	13	16	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:184099561C>T	uc003fov.2	+	5	815	c.569C>T	c.(568-570)TCG>TTG	p.S190L	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Missense_Mutation_p.S190L|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	190	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCCGAGTCTCGCTGCTGCGC	0.662													0	0	0	0.00245	0	13	26										T	184099561	C	T	184099561	3	4	16	1	0	0	0	0	1	0	0	0	3372	893	31	1	587	1	CHRD	3	184099561	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	434383	184099561	13922869	198	3921										
VPS8	23355	broad.mit.edu	37	chr3	184612519	184612519	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatttagtcagatgtatgatAaattaagtgagaattcagtg	9	2	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:184612519A>G	uc003fpb.1	+	22	1975	c.1804A>G	c.(1804-1806)AAA>GAA	p.K602E	VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Missense_Mutation_p.K31E	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	604							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GATGTATGATAAATTAAGTGA	0.353													0	0	0	0.009096	0	3	14										G	184612519	A	G	184612519	3	3	16	1	0	0	0	0	1	0	0	0	17215	363	13	5	1892	5	VPS8	3	184612519	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	512958	184612519	13409911	199	3922										
OPA1	4976	broad.mit.edu	37	chr3	193372785	193372785	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatcaagcttaaacagtggaCtgataaacaacttcctaata	5	8	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:193372785C>T	uc003ftm.2	+	20	2216	c.1982C>T	c.(1981-1983)ACT>ATT	p.T661I	OPA1_uc003ftg.2_Missense_Mutation_p.T716I|OPA1_uc003fth.2_Missense_Mutation_p.T680I|OPA1_uc003fti.2_Missense_Mutation_p.T698I|OPA1_uc003ftj.2_Missense_Mutation_p.T679I|OPA1_uc003ftk.2_Missense_Mutation_p.T662I|OPA1_uc003ftl.2_Missense_Mutation_p.T643I|OPA1_uc003ftn.2_Missense_Mutation_p.T625I	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	661	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		AAACAGTGGACTGATAAACAA	0.368													0	0	0	0.008871	0	14	27										T	193372785	C	T	193372785	3	4	16	1	0	0	0	0	1	0	0	0	10871	565	20	2	2233	2	OPA1	3	193372785	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8760266	193372785	4649645	200	3923										
ZNF595	152687	broad.mit.edu	37	chr4	86807	86807	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acaacactgaacgaacataaGaaaattcatactggcgagaa	7	8	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:86807G>T	uc003fzv.1	+	6	1569	c.1413G>T	c.(1411-1413)AAG>AAT	p.K471N	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.K239N|ZNF595_uc011but.1_Missense_Mutation_p.K239N	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	471					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		ACGAACATAAGAAAATTCATA	0.388													1	0	0.00024832	0.009096	0.000257894	4	19										T	86807	G	T	86807	3	4	16	1	0	0	0	0	1	0	0	0	18022	942	33	3	1426	3	ZNF595	4	86807	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		86807	191067469	201	3924										
ZNF595	152687	broad.mit.edu	37	chr4	87051	87051	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcggtccacagccctgaatGaacataagaaaattcattct	6	11	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:87051G>C	uc003fzv.1	+	6	1813	c.1657G>C	c.(1657-1659)GAA>CAA	p.E553Q	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.E321Q|ZNF595_uc011but.1_Missense_Mutation_p.E321Q	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	553					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		AGCCCTGAATGAACATAAGAA	0.378													0	0	0	0.008291	0	10	33										C	87051	G	C	87051	3	2	16	1	0	0	0	0	1	0	0	0	18022	1290	45	1	1670	1	ZNF595	4	87051	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	244	87051	191067225	202	3925										
FAM193A	8603	broad.mit.edu	37	chr4	2664635	2664635	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttatccattgagtaattatGatgataccgaggtggtggcc	11	6	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:2664635G>A	uc010icl.2	+	9	1294	c.943G>A	c.(943-945)GAT>AAT	p.D315N	FAM193A_uc010ick.2_Missense_Mutation_p.D515N|FAM193A_uc003gfd.2_Missense_Mutation_p.D315N|FAM193A_uc011bvm.1_Missense_Mutation_p.D337N|FAM193A_uc011bvn.1_Missense_Mutation_p.D315N|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.D169N	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	315										ovary(3)	3						GAGTAATTATGATGATACCGA	0.453													0	0	0	0.006122	0	18	45										A	2664635	G	A	2664635	3	1	16	1	0	0	0	0	1	0	0	0	5524	1290	45	1	969	1	FAM193A	4	2664635	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2577584	2664635	188489641	203	3926										
JAKMIP1	152789	broad.mit.edu	37	chr4	6107461	6107461	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	accttgtcggccgcgccgtcGcgcagcacgttcagcgtggc	14	16	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:6107461G>A	uc003giu.3	-	3	639	c.363C>T	c.(361-363)CGC>CGT	p.R121R	JAKMIP1_uc010idb.1_Silent_p.R121R|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Silent_p.R121R|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Silent_p.R121R|JAKMIP1_uc010ide.2_Silent_p.R121R	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	121	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCGCGCCGTCGCGCAGCACGT	0.726													0	0	0	0.001984	0	6	11										A	6107461	G	A	6107461	2	1	16	1	0	0	0	0	0	0	0	1	7940	1074	38	2		2	JAKMIP1	4	6107461	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3442826	6107461	185046815	204	3927										
ABLIM2	84448	broad.mit.edu	37	chr4	8021986	8021986	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggaggggggcggcttgctgtCagagagcacggagaggctgg	22	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:8021986C>T	uc003gko.2	-	12	1356	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N	ABLIM2_uc003gkk.2_Missense_Mutation_p.D68N|ABLIM2_uc003gkl.2_Intron|ABLIM2_uc003gkj.3_Missense_Mutation_p.D438N|ABLIM2_uc003gkm.3_Intron|ABLIM2_uc003gkp.2_Intron|ABLIM2_uc003gkq.2_Missense_Mutation_p.D405N|ABLIM2_uc003gkr.2_Intron|ABLIM2_uc003gks.3_Intron	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	405					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						GGCTTGCTGTCAGAGAGCACG	0.622													0	0	0	0.001984	0	7	27										T	8021986	C	T	8021986	3	4	16	1	0	0	0	0	1	0	0	0	95	826	29	1	678	1	ABLIM2	4	8021986	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1914525	8021986	183132290	205	3928										
FAM114A1	92689	broad.mit.edu	37	chr4	38916603	38916603	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagcagctcacgatggagaGaaccgcgcactacgggatgc	13	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:38916603G>C	uc003gtn.2	+	8	1030	c.854G>C	c.(853-855)AGA>ACA	p.R285T	FAM114A1_uc011byh.1_Missense_Mutation_p.R78T	NM_138389	NP_612398	Q8IWE2	NXP20_HUMAN	hypothetical protein LOC92689	285						cytoplasm				ovary(1)	1						ACGATGGAGAGAACCGCGCAC	0.468													0	0	0	0.00245	0	13	21										C	38916603	G	C	38916603	3	2	16	1	0	0	0	0	1	0	0	0	5403	942	33	1	876	1	FAM114A1	4	38916603	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	30894617	38916603	152237673	206	3929										
N4BP2	55728	broad.mit.edu	37	chr4	40104102	40104102	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggttctactttaagtttaAacccattaccttcacattca	3	11	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:40104102A>C	uc003guy.3	+	4	975	c.637A>C	c.(637-639)AAC>CAC	p.N213H	N4BP2_uc010ifq.2_Missense_Mutation_p.N133H|N4BP2_uc010ifr.2_Missense_Mutation_p.N133H	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	213						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTTAAGTTTAAACCCATTACC	0.328													0	0	0	0.006214	0	10	19										C	40104102	A	C	40104102	3	2	16	1	0	0	0	0	1	0	0	0	10110	14	1	5	643	5	N4BP2	4	40104102	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1187499	40104102	151050174	207	3930										
UGT2A3	79799	broad.mit.edu	37	chr4	69796299	69796299	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actgttctcaaagccctcagTaaatcttcgcttgtcatagt	6	11	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:69796299T>G	uc003hef.2	-	5	1300	c.1269A>C	c.(1267-1269)TTA>TTC	p.L423F	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	423	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AAGCCCTCAGTAAATCTTCGC	0.383													0	0	0	0.001855	0	13	71										G	69796299	T	G	69796299	3	3	16	1	0	0	0	0	1	0	0	0	16952	1635	57	5	322	5	UGT2A3	4	69796299	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	29692197	69796299	121357977	208	3931										
UGT2B7	7364	broad.mit.edu	37	chr4	69962754	69962754	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ataccctttgtgtacagtctCagcttctctcctggctacac	6	14	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:69962754C>T	uc003heg.3	+	1	562	c.516C>T	c.(514-516)CTC>CTT	p.L172L	UGT2B7_uc010ihq.2_Silent_p.L172L	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	172					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TGTACAGTCTCAGCTTCTCTC	0.398													0	0	0	0.008871	0	19	65										T	69962754	C	T	69962754	2	4	16	1	0	0	0	0	0	0	0	1	16959	813	29	1		1	UGT2B7	4	69962754	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	166455	69962754	121191522	209	3932										
FRAS1	80144	broad.mit.edu	37	chr4	79430001	79430001	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccctgcgaccctcatttcccCagatacgctgtcatgaagga	8	15	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:79430001C>T	uc003hlb.2	+	63	10061	c.9621C>T	c.(9619-9621)CCC>CCT	p.P3207P	FRAS1_uc003hlc.1_Silent_p.P209P	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3202	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTCATTTCCCCAGATACGCTG	0.572													0	0	0	0.009096	0	4	13										T	79430001	C	T	79430001	2	4	16	1	0	0	0	0	0	0	0	1	6042	581	21	2		2	FRAS1	4	79430001	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	9467247	79430001	111724275	210	3933										
FRAS1	80144	broad.mit.edu	37	chr4	79430151	79430151	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aacacaccattcaccagtgtCaaccacatggtaggtctggg	9	12	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:79430151C>T	uc003hlb.2	+	63	10211	c.9771C>T	c.(9769-9771)GTC>GTT	p.V3257V	FRAS1_uc003hlc.1_Silent_p.V259V	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3252	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TCACCAGTGTCAACCACATGG	0.532													0	0	0	0.001855	0	12	48										T	79430151	C	T	79430151	2	4	16	1	0	0	0	0	0	0	0	1	6042	813	29	1		1	FRAS1	4	79430151	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	150	79430151	111724125	211	3934										
TIGD2	166815	broad.mit.edu	37	chr4	90034836	90034836	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccaaaaagccccgagcattCaaaggcactgacctttcaaa	7	13	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:90034836C>T	uc003hsk.2	+	1	869	c.711C>T	c.(709-711)TTC>TTT	p.F237F	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	237	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		CCCGAGCATTCAAAGGCACTG	0.418													0	0	0	0.006214	0	10	32										T	90034836	C	T	90034836	2	4	16	1	0	0	0	0	0	0	0	1	15893	825	29	1		1	TIGD2	4	90034836	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	10604685	90034836	101119440	212	3935										
BMPR1B	658	broad.mit.edu	37	chr4	96045003	96045003	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccacagggctttacttatatCtgtgactgtctgtagtttgc	9	9	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:96045003C>T	uc003htm.3	+	7	666	c.392C>T	c.(391-393)TCT>TTT	p.S131F	BMPR1B_uc010ilb.2_Missense_Mutation_p.S131F|BMPR1B_uc003htn.3_Missense_Mutation_p.S131F	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	131	Helical; (Potential).				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		TTACTTATATCTGTGACTGTC	0.294													0	0	0	0.004289	0	30	71										T	96045003	C	T	96045003	3	4	16	1	0	0	0	0	1	0	0	0	1470	913	32	1	406	1	BMPR1B	4	96045003	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6010167	96045003	95109273	213	3936										
ADH4	127	broad.mit.edu	37	chr4	100047780	100047780	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attaggtcaaatgcctcactGattttgtcaaaaggcagggt	10	7	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:100047780G>A	uc003hun.2	-	8	1159	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I	uc003hum.1_Intron|ADH4_uc011ced.1_Silent_p.I380I	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	361					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	ATGCCTCACTGATTTTGTCAA	0.353													0	0	0	0.014323	0	17	46										A	100047780	G	A	100047780	2	1	16	1	0	0	0	0	0	0	0	1	310	1280	45	1		1	ADH4	4	100047780	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4002777	100047780	91106496	214	3937										
PPP3CA	5530	broad.mit.edu	37	chr4	101947192	101947192	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcctcgaagctagtgatctTatgttgtggtgaaaatcctt	9	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:101947192T>C	uc011cen.1	-	14	2071	c.1396A>G	c.(1396-1398)AAG>GAG	p.K466E	PPP3CA_uc003hvu.2_Missense_Mutation_p.K456E|PPP3CA_uc010ilj.2_Missense_Mutation_p.K414E|PPP3CA_uc003hvt.2_Missense_Mutation_p.K443E|PPP3CA_uc003hvs.2_Missense_Mutation_p.K399E|PPP3CA_uc010ilk.2_Missense_Mutation_p.K234E	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	466	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		CTAGTGATCTTATGTTGTGGT	0.443													0	0	0	0.004007	0	14	42										C	101947192	T	C	101947192	3	2	16	1	0	0	0	0	1	0	0	0	12397	1763	61	5	173	5	PPP3CA	4	101947192	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1899412	101947192	89207084	215	3938										
NFKB1	4790	broad.mit.edu	37	chr4	103534637	103534637	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctgagacaaatgggctacaCcgaagcaattgaagtgatcc	10	10	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:103534637C>T	uc011ceq.1	+	23	3112	c.2645C>T	c.(2644-2646)ACC>ATC	p.T882I	NFKB1_uc011cep.1_Missense_Mutation_p.T883I|NFKB1_uc011cer.1_Missense_Mutation_p.T702I	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	882	Death.|Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	ATGGGCTACACCGAAGCAATT	0.562													0	0	0	0.009096	0	4	27										T	103534637	C	T	103534637	3	4	16	1	0	0	0	0	1	0	0	0	10375	507	18	2	2734	2	NFKB1	4	103534637	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1587445	103534637	87619639	216	3939										
GAR1	54433	broad.mit.edu	37	chr4	110737358	110737358	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggtcgtggaggctttaatcGaggtggtggaggtggcggct	20	5	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:110737358G>C	uc003hzt.2	+	2	345	c.38G>C	c.(37-39)CGA>CCA	p.R13P	GAR1_uc003hzu.2_Missense_Mutation_p.R13P|GAR1_uc010imh.1_Missense_Mutation_p.R13P|GAR1_uc010imi.2_Missense_Mutation_p.R13P	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	13	RGG-box 1.				rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						GGCTTTAATCGAggtggtgga	0.234													0	0	0	0.012319	0	22	44										C	110737358	G	C	110737358	3	2	16	1	0	0	0	0	1	0	0	0	6240	1058	37	1	40	1	GAR1	4	110737358	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7202721	110737358	80416918	217	3940										
NAA15	80155	broad.mit.edu	37	chr4	140299923	140299923	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttatagaaaagtttcttttGatgctacaatcagtaaagag	7	4	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:140299923G>A	uc003ihu.1	+	17	2326	c.2070G>A	c.(2068-2070)TTG>TTA	p.L690L		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	690	TPR 8.				angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						AGTTTCTTTTGATGCTACAAT	0.338													0	0	0	0.013537	0	13	30										A	140299923	G	A	140299923	2	1	16	1	0	0	0	0	0	0	0	1	10118	1281	45	1		1	NAA15	4	140299923	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	29562565	140299923	50854353	218	3941										
PRMT10	90826	broad.mit.edu	37	chr4	148605049	148605049	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccagacagtgctctgcgctCtgcaaggaccgcgacaccag	11	16	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:148605049C>T	uc003ilc.2	-	1	232	c.90G>A	c.(88-90)CAG>CAA	p.Q30Q	PRMT10_uc003ild.2_5'UTR	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	30	TPR 1.					cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						GCTCTGCGCTCTGCAAGGACC	0.692													0	0	0	0.00245	0	15	34										T	148605049	C	T	148605049	2	4	16	1	0	0	0	0	0	0	0	1	12536	912	32	1		1	PRMT10	4	148605049	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8305126	148605049	42549227	219	3942										
DCHS2	54798	broad.mit.edu	37	chr4	155305519	155305519	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcaccacctgactgacctcaCctcagtttccttcactggtt	6	16	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:155305519C>T	uc003inw.2	-	2	234	c.234_splice	c.e2+1	p.E78_splice	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		actgacctcacctcagtttcc	0													0	0	0	0.00245	0	11	32										T	155305519	C	T	155305519	5	4	16	1	0	0	0	0	0	0	1	0	4288	521	18	2	8707	2	DCHS2	4	155305519	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6700470	155305519	35848757	220	3943										
FGB	2244	broad.mit.edu	37	chr4	155487699	155487699	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttgctacaacaggaaaggcCaatcagaaatagtgttgatg	10	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:155487699C>A	uc003ioa.3	+	3	404	c.365C>A	c.(364-366)CCA>CAA	p.P122Q	FGB_uc010ipu.1_RNA|FGB_uc003iob.3_Missense_Mutation_p.P119Q|FGB_uc010ipv.2_Missense_Mutation_p.P60Q|FGB_uc010ipw.2_Missense_Mutation_p.P119Q|FGB_uc003ioc.3_Intron	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	122					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CAGGAAAGGCCAATCAGAAAT	0.418													1	0	0.000308642	0.003163	0.000319004	15	34										A	155487699	C	A	155487699	3	1	16	1	0	0	0	0	1	0	0	0	5831	594	21	4	375	4	FGB	4	155487699	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	182180	155487699	35666577	221	3944										
FNIP2	57600	broad.mit.edu	37	chr4	159747136	159747136	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaggactgtgacaggagagGcagacaagtcttgtttgact	13	8	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:159747136G>A	uc003iqe.3	+	2	359	c.176G>A	c.(175-177)GGC>GAC	p.G59D	FNIP2_uc003iqd.2_Missense_Mutation_p.G59D	NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	59					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		GACAGGAGAGGCAGACAAGTC	0.413													0	0	0	0.003755	0	36	81										A	159747136	G	A	159747136	3	1	16	1	0	0	0	0	1	0	0	0	5976	1203	42	2	182	2	FNIP2	4	159747136	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4259437	159747136	31407140	222	3945										
FSTL5	56884	broad.mit.edu	37	chr4	162697045	162697045	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	catacctgagttagttcattAatatctacaagtccattact	4	9	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:162697045A>C	uc003iqh.2	-	5	1027	c.591T>G	c.(589-591)ATT>ATG	p.I197M	FSTL5_uc003iqi.2_Missense_Mutation_p.I196M|FSTL5_uc010iqv.2_Missense_Mutation_p.I196M	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	197	1 (Potential).|EF-hand 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTAGTTCATTAATATCTACAA	0.289													0	0	0	0.000602	0	4	27										C	162697045	A	C	162697045	3	2	16	1	0	0	0	0	1	0	0	0	6080	358	13	5	2000	5	FSTL5	4	162697045	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2949909	162697045	28457231	223	3946										
NPY1R	4886	broad.mit.edu	37	chr4	164246583	164246583	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgtttcataatcatcatcccGagaccggaaatcacaaaagt	6	10	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:164246583G>C	uc003iqm.1	-	3	1293	c.1027C>G	c.(1027-1029)CGG>GGG	p.R343G	NPY1R_uc011cjj.1_Missense_Mutation_p.R100G	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	343	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCATCATCCCGAGACCGGAAA	0.393													0	0	0	0.007413	0	20	54										C	164246583	G	C	164246583	3	2	16	1	0	0	0	0	1	0	0	0	10608	1057	37	1	131	1	NPY1R	4	164246583	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1549538	164246583	26907693	224	3947										
TRIM60	166655	broad.mit.edu	37	chr4	165961621	165961621	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agaagcactacatttgccctAttaagaaagctgcctcttat	6	10	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:165961621A>G	uc003iqy.1	+	3	567	c.397A>G	c.(397-399)ATT>GTT	p.I133V	TRIM60_uc010iqx.1_Missense_Mutation_p.I133V	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	133	B box-type.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		CATTTGCCCTATTAAGAAAGC	0.398													0	0	0	0.010729	0	11	26										G	165961621	A	G	165961621	3	3	16	1	0	0	0	0	1	0	0	0	16532	449	16	5	399	5	TRIM60	4	165961621	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1715038	165961621	25192655	225	3948										
SPOCK3	50859	broad.mit.edu	37	chr4	167921549	167921549	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gactgcagtctgagaatcttGagcaatgcatactttatggc	10	8	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:167921549G>A	uc003iri.1	-	5	451	c.310C>T	c.(310-312)CAA>TAA	p.Q104*	SPOCK3_uc011cjp.1_Nonsense_Mutation_p.Q101*|SPOCK3_uc011cjq.1_Nonsense_Mutation_p.Q113*|SPOCK3_uc011cjr.1_Intron|SPOCK3_uc003irj.1_Nonsense_Mutation_p.Q101*|SPOCK3_uc011cjs.1_Nonsense_Mutation_p.Q53*|SPOCK3_uc011cjt.1_Nonsense_Mutation_p.Q12*|SPOCK3_uc011cju.1_Intron|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Nonsense_Mutation_p.Q101*|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	104					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TGAGAATCTTGAGCAATGCAT	0.378													0	0	0	0.010504	0	19	33										A	167921549	G	A	167921549	4	1	16	1	0	0	0	0	0	1	0	0	15080	1299	45	1	1032	1	SPOCK3	4	167921549	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1959928	167921549	23232727	226	3949										
DDX60L	91351	broad.mit.edu	37	chr4	169296610	169296610	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggaaggaggcaaaatccttCattactgccaggttatactc	9	9	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:169296610C>T	uc003irq.3	-	34	4772	c.4551G>A	c.(4549-4551)ATG>ATA	p.M1517I		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1517							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CAAAATCCTTCATTACTGCCA	0.408													0	0	0	0.000602	0	4	14										T	169296610	C	T	169296610	3	4	16	1	0	0	0	0	1	0	0	0	4379	826	29	1	589	1	DDX60L	4	169296610	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1375061	169296610	21857666	227	3950										
ODZ3	55714	broad.mit.edu	37	chr4	183267957	183267957	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgaagcagtgatgtccccagAgcatgccatgagactttggg	13	9	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:183267957A>G	uc003ivd.1	+	2	423	c.386A>G	c.(385-387)GAG>GGG	p.E129G	ODZ3_uc010irv.1_Missense_Mutation_p.E129G	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	129	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ATGTCCCCAGAGCATGCCATG	0.557													0	0	0	0.001984	0	7	6										G	183267957	A	G	183267957	3	3	16	1	0	0	0	0	1	0	0	0	10836	304	11	5	392	5	ODZ3	4	183267957	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	13971347	183267957	7886319	228	3951										
FAT1	2195	broad.mit.edu	37	chr4	187628629	187628629	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attcagggtgtatttgtctgTtgtttcacggtcaagaggag	13	5	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:187628629T>C	uc003izf.2	-	2	2541	c.2353A>G	c.(2353-2355)ACA>GCA	p.T785A	FAT1_uc010iso.1_Missense_Mutation_p.T785A	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	785	Extracellular (Potential).|Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TATTTGTCTGTTGTTTCACGG	0.433										HNSCC(5;0.00058)			0	0	0	0.004656	0	26	85										C	187628629	T	C	187628629	3	2	16	1	0	0	0	0	1	0	0	0	5689	1725	60	5	11517	5	FAT1	4	187628629	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	4360672	187628629	3525647	229	3952										
KIAA0947	23379	broad.mit.edu	37	chr5	5460633	5460633	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgagtgtgtttcagaagatGatacaactgaatcacagaat	9	6	2	6			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:5460633G>A	uc003jdm.3	+	13	1408	c.1186G>A	c.(1186-1188)GAT>AAT	p.D396N		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	396										ovary(1)|central_nervous_system(1)	2						TTCAGAAGATGATACAACTGA	0.373													0	0	0	0.009096	0	4	6										A	5460633	G	A	5460633	3	1	16	1	0	0	0	0	1	0	0	0	8202	1290	45	1	1236	1	KIAA0947	5	5460633	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		5460633	175454627	230	3953										
RICTOR	253260	broad.mit.edu	37	chr5	38963033	38963033	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actgatcccgtttctggtgtGttgcaattgctttctgaata	9	8	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:38963033G>C	uc003jlp.2	-	17	1535	c.1511C>G	c.(1510-1512)ACA>AGA	p.T504R	RICTOR_uc003jlo.2_Missense_Mutation_p.T504R|RICTOR_uc010ivf.2_Missense_Mutation_p.T219R	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	504					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTTCTGGTGTGTTGCAATTGC	0.368													0	0	0	0.014323	0	21	33										C	38963033	G	C	38963033	3	2	16	1	0	0	0	0	1	0	0	0	13358	1377	48	4	3703	4	RICTOR	5	38963033	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	33502400	38963033	141952227	231	3954										
SLC38A9	153129	broad.mit.edu	37	chr5	54922436	54922436	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggagggaaattatatagatGagagatgggtatatgaatac	13	1	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:54922436G>A	uc003jqf.2	-	16	1773	c.1572C>T	c.(1570-1572)CTC>CTT	p.L524L	SLC38A9_uc003jqd.2_Silent_p.L461L|SLC38A9_uc010ivx.2_Silent_p.L461L|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.L395L	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	524	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				TTATATAGATGAGAGATGGGT	0.398													0	0	0	0.004289	0	32	58										A	54922436	G	A	54922436	2	1	16	1	0	0	0	0	0	0	0	1	14611	1277	45	1		1	SLC38A9	5	54922436	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	15959403	54922436	125992824	232	3955										
F2R	2149	broad.mit.edu	37	chr5	76028967	76028967	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttccgcagttgccaaccgcaGcaagaagtcccgggctttgt	11	13	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:76028967G>T	uc003ken.3	+	2	1182	c.917G>T	c.(916-918)AGC>ATC	p.S306I		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	306	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	GCCAACCGCAGCAAGAAGTCC	0.488													1	0	1.17739e-12	0.005443	1.26233e-12	28	31										T	76028967	G	T	76028967	3	4	16	1	0	0	0	0	1	0	0	0	5343	971	34	4	923	4	F2R	5	76028967	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	21106531	76028967	104886293	233	3956										
ARSK	153642	broad.mit.edu	37	chr5	94891054	94891054	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcccccggagcaggggagcaGaggcggagagcagccaaagc	18	12	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:94891054G>A	uc003kld.2	+	1	230	c.72G>A	c.(70-72)CAG>CAA	p.Q24Q	ARSK_uc010jbg.2_5'UTR|ARSK_uc011cum.1_RNA|TTC37_uc003klb.2_5'Flank|TTC37_uc010jbf.1_5'Flank|ARSK_uc003klc.2_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	24						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CAGGGGAGCAGAGGCGGAGAG	0.697													0	0	0	0.001168	0	6	20										A	94891054	G	A	94891054	2	1	16	1	0	0	0	0	0	0	0	1	996	933	33	1		1	ARSK	5	94891054	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	18862087	94891054	86024206	234	3957										
CHD1	1105	broad.mit.edu	37	chr5	98195774	98195774	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tacaaaaatccacaggtttcTagaagaatttaaaaaaaggc	6	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:98195774T>C	uc003knf.2	-	32	4576	c.4428_splice	c.e32-1	p.K1476_splice	CHD1_uc010jbn.2_Splice_Site_p.K202_splice	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CACAGGTTTCTAGAAGAATTT	0.313													0	0	0	0.001984	0	7	31										C	98195774	T	C	98195774	5	2	16	1	0	0	0	0	0	0	1	0	3323	1536	53	5	722	5	CHD1	5	98195774	Splice_Site	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	3304720	98195774	82719486	235	3958										
SLC25A46	91137	broad.mit.edu	37	chr5	110091194	110091194	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acataaatggagtcctaaacAaataggagaacaccttctac	6	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:110091194A>G	uc003koz.2	+	6	660	c.593A>G	c.(592-594)CAA>CGA	p.Q198R	SLC25A46_uc011cvi.1_Missense_Mutation_p.Q107R	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	198					transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		AGTCCTAAACAAATAGGAGAA	0.279													0	0	0	0.012319	0	16	39										G	110091194	A	G	110091194	3	3	16	1	0	0	0	0	1	0	0	0	14511	130	5	5	615	5	SLC25A46	5	110091194	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	11895420	110091194	70824066	236	3959										
APC	324	broad.mit.edu	37	chr5	112154981	112154981	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aacagatacgcgcttactgtGaaacctgttgggagtggcag	13	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:112154981G>T	uc010jby.2	+	10	1632	c.1252G>T	c.(1252-1254)GAA>TAA	p.E418*	APC_uc011cvt.1_Nonsense_Mutation_p.E400*|APC_uc003kpz.3_Nonsense_Mutation_p.E418*|APC_uc003kpy.3_Nonsense_Mutation_p.E418*|APC_uc010jbz.2_Nonsense_Mutation_p.E135*|APC_uc010jca.2_5'Flank	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	418	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CGCTTACTGTGAAACCTGTTG	0.468		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			1	0	7.53189e-24	0.007835	8.1564e-24	36	30										T	112154981	G	T	112154981	4	4	16	1	0	0	0	0	0	1	0	0	763	1291	45	3	1286	3	APC	5	112154981	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2063787	112154981	68760279	237	3960										
CAMLG	819	broad.mit.edu	37	chr5	134074448	134074448	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcggaacagcgcatcaaccgGatcatgggctttcacaggcc	11	13	3	0	rs146867024		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:134074448G>A	uc003kzt.2	+	1	243	c.138G>A	c.(136-138)CGG>CGA	p.R46R	CAMLG_uc003kzu.2_Silent_p.R46R	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand	46	Cytoplasmic (Potential).				defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	GCATCAACCGGATCATGGGCT	0.637													0	0	0	0.000602	0	5	44										A	134074448	G	A	134074448	2	1	16	1	0	0	0	0	0	0	0	1	2609	1161	41	1		1	CAMLG	5	134074448	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	21919467	134074448	46840812	238	3961										
CXCL14	9547	broad.mit.edu	37	chr5	134914132	134914132	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcgagaactcacataaccatCttctcctcgcagtgcgggta	9	13	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:134914132C>A	uc003lay.2	-	2	663	c.198G>T	c.(196-198)AAG>AAT	p.K66N		NM_004887	NP_004878	O95715	CXL14_HUMAN	small inducible cytokine B14 precursor	66					cell-cell signaling|chemotaxis|immune response|signal transduction	extracellular space|Golgi apparatus	chemokine activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACATAACCATCTTCTCCTCGC	0.572													1	0	8.58068e-18	0.007291	9.26886e-18	29	66										A	134914132	C	A	134914132	3	1	16	1	0	0	0	0	1	0	0	0	4082	912	32	3	149	3	CXCL14	5	134914132	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	839684	134914132	46001128	239	3962										
APBB3	10307	broad.mit.edu	37	chr5	139938224	139938224	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaggcatcaagaaaagagaaGacaccccgctttcgaggggt	12	9	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:139938224G>C	uc003lgd.1	-	12	1781	c.1422C>G	c.(1420-1422)GTC>GTG	p.V474V	SRA1_uc003lfz.2_5'Flank|SRA1_uc010jfm.2_5'Flank|SRA1_uc003lga.2_5'Flank|APBB3_uc003lgb.1_Silent_p.V246V|APBB3_uc003lgc.1_Silent_p.V246V|APBB3_uc003lge.1_Silent_p.V467V|APBB3_uc003lgf.1_RNA|APBB3_uc010jfp.1_RNA|APBB3_uc011czi.1_Silent_p.V246V	NM_133172	NP_573418	O95704	APBB3_HUMAN	amyloid beta precursor protein-binding, family	469						actin cytoskeleton|cytoplasm				ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAAGAGAAGACACCCCGCT	0.597													0	0	0	0.006999	0	41	66										C	139938224	G	C	139938224	2	2	16	1	0	0	0	0	0	0	0	1	762	929	33	1		1	APBB3	5	139938224	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5024092	139938224	40977036	240	3963										
PCDHA10	56139	broad.mit.edu	37	chr5	140237513	140237513	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtttcgcgtggggctgtacaCgggcgagatcagtacgacgc	16	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:140237513C>T	uc003lhx.2	+	1	1880	c.1880C>T	c.(1879-1881)ACG>ATG	p.T627M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.T627M	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	627	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTGTACACGGGCGAGATC	0.647													0	0	0	0.003163	0	15	3										T	140237513	C	T	140237513	3	4	16	1	0	0	0	0	1	0	0	0	11520	536	19	2	1882	2	PCDHA10	5	140237513	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	299289	140237513	40677747	241	3964										
PCDHGB1	56104	broad.mit.edu	37	chr5	140730558	140730558	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgtgtttagccaggaggtatAcagggttagcctccaagaaa	12	8	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:140730558A>G	uc003ljo.1	+	1	731	c.731A>G	c.(730-732)TAC>TGC	p.Y244C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.Y244C	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	244	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGAGGTATACAGGGTTAGC	0.567													0	0	0	0.004007	0	16	46										G	140730558	A	G	140730558	3	3	16	1	0	0	0	0	1	0	0	0	11562	391	14	5	733	5	PCDHGB1	5	140730558	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	493045	140730558	40184702	242	3965										
PCDH1	5097	broad.mit.edu	37	chr5	141244801	141244801	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgggcacgggcactcttgggGttggtgcctcggtccttagc	16	11	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:141244801G>A	uc003llq.2	-	3	1212	c.1095C>T	c.(1093-1095)AAC>AAT	p.N365N	PCDH1_uc003llp.2_Silent_p.N365N|PCDH1_uc011dbf.1_Silent_p.N343N	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	365	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CACTCTTGGGGTTGGTGCCTC	0.577													0	0	0	0.014323	0	19	104										A	141244801	G	A	141244801	2	1	16	1	0	0	0	0	0	0	0	1	11506	1252	44	2		2	PCDH1	5	141244801	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	514243	141244801	39670459	243	3966										
RBM27	54439	broad.mit.edu	37	chr5	145634557	145634557	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agctcctagtattactagttCtggtagatctcagtacagac	8	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:145634557C>T	uc003lnz.3	+	10	1662	c.1496C>T	c.(1495-1497)TCT>TTT	p.S499F	RBM27_uc003lny.2_Missense_Mutation_p.S444F	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	499					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTACTAGTTCTGGTAGATCT	0.408													0	0	0	0.007413	0	16	31										T	145634557	C	T	145634557	3	4	16	1	0	0	0	0	1	0	0	0	13127	913	32	1	1534	1	RBM27	5	145634557	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4389756	145634557	35280703	244	3967										
GPR151	134391	broad.mit.edu	37	chr5	145895361	145895361	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttgcagacaaaccagcctaGatcccaaacacttttggagt	7	12	0	2	rs147138565	byFrequency	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:145895361G>T	uc003lod.1	-	1	316	c.316C>A	c.(316-318)CTA>ATA	p.L106I		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	106	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACCAGCCTAGATCCCAAACA	0.507													1	0	1.5842e-08	0.001855	1.67351e-08	14	60										T	145895361	G	T	145895361	3	4	16	1	0	0	0	0	1	0	0	0	6657	933	33	3	947	3	GPR151	5	145895361	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	260804	145895361	35019899	245	3968										
PCYOX1L	78991	broad.mit.edu	37	chr5	148743624	148743624	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggcaccggcgcgaggtggtGggcaggagcgccatcttcgg	19	11	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:148743624G>C	uc003lqk.2	+	3	383	c.321G>C	c.(319-321)GTG>GTC	p.V107V	PCYOX1L_uc003lql.2_Silent_p.V90V|PCYOX1L_uc010jgz.2_Silent_p.V90V|PCYOX1L_uc003lqm.2_5'UTR|PCYOX1L_uc003lqn.2_Silent_p.V17V	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	107					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGGTGGTGGGCAGGAGCG	0.617													0	0	0	0.013537	0	11	60										C	148743624	G	C	148743624	2	2	16	1	0	0	0	0	0	0	0	1	11609	1335	47	4		4	PCYOX1L	5	148743624	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2848263	148743624	32171636	246	3969										
ZNF300	91975	broad.mit.edu	37	chr5	150275006	150275006	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttatgattttaccactgtgtGaattctctggtgtacagtta	8	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:150275006G>A	uc003lsy.1	-	6	2062	c.1795C>T	c.(1795-1797)CAC>TAC	p.H599Y	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	599	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCACTGTGTGAATTCTCTGG	0.388													0	0	0	0.00308	0	7	46										A	150275006	G	A	150275006	3	1	16	1	0	0	0	0	1	0	0	0	17828	1290	45	1	23	1	ZNF300	5	150275006	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1531382	150275006	30640254	247	3970										
NMUR2	56923	broad.mit.edu	37	chr5	151784387	151784387	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acctccaggggcattccaagGagcaggaccaggaggtcaga	14	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:151784387G>T	uc003luv.2	-	1	454	c.288C>A	c.(286-288)CTC>CTA	p.L96L		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	96	Helical; Name=2; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GCATTCCAAGGAGCAGGACCA	0.577													1	0	1.90571e-15	0.004289	2.04828e-15	33	65										T	151784387	G	T	151784387	2	4	16	1	0	0	0	0	0	0	0	1	10507	1161	41	3		3	NMUR2	5	151784387	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1509381	151784387	29130873	248	3971										
LSM11	134353	broad.mit.edu	37	chr5	157171172	157171172	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggggtccgggtcggagcagGaaggcgccacgcaacgtgct	18	11	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:157171172G>A	uc003lxe.1	+	1	418	c.414G>A	c.(412-414)AGG>AGA	p.R138R		NM_173491	NP_775762	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	138					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCGGAGCAGGAAGGCGCCAC	0.751													0	0	0	0.004672	0	3	4										A	157171172	G	A	157171172	2	1	16	1	0	0	0	0	0	0	0	1	9052	1165	41	1		1	LSM11	5	157171172	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5386785	157171172	23744088	249	3972										
ATP10B	23120	broad.mit.edu	37	chr5	160033923	160033923	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttccctggaagatggcattCaatgtcttcccatcgatgac	8	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:160033923C>G	uc003lym.1	-	19	3856	c.3009G>C	c.(3007-3009)TTG>TTC	p.L1003F	ATP10B_uc010jit.1_Missense_Mutation_p.L320F	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1003	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATGGCATTCAATGTCTTCC	0.512													0	0	0	0.00245	0	12	88										G	160033923	C	G	160033923	3	3	16	1	0	0	0	0	1	0	0	0	1117	825	29	1	1408	1	ATP10B	5	160033923	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2862751	160033923	20881337	250	3973										
HMMR	3161	broad.mit.edu	37	chr5	162894721	162894721	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaacagaaggaatctcaaaaGaatgataaagatttgaagat	8	3	1	6			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:162894721G>A	uc003lzf.2	+	4	419	c.237G>A	c.(235-237)AAG>AAA	p.K79K	HMMR_uc003lzh.2_Silent_p.K80K|HMMR_uc003lzg.2_Intron|HMMR_uc011dem.1_Intron	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	79						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		AATCTCAAAAGAATGATAAAG	0.294													0	0	0	0.004672	0	3	19										A	162894721	G	A	162894721	2	1	16	1	0	0	0	0	0	0	0	1	7242	933	33	1		1	HMMR	5	162894721	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2860798	162894721	18020539	251	3974										
SLIT3	6586	broad.mit.edu	37	chr5	168175367	168175367	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggagccccttgttgctgcatCgcaccactgtctccatacag	9	15	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:168175367C>T	uc003mab.2	-	20	2630	c.2210G>A	c.(2209-2211)CGA>CAA	p.R737Q	SLIT3_uc010jjg.2_Missense_Mutation_p.R737Q	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	737	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTGCTGCATCGCACCACTGT	0.642													0	0	0	0.004289	0	36	64										T	168175367	C	T	168175367	3	4	16	1	0	0	0	0	1	0	0	0	14741	884	31	1	2429	1	SLIT3	5	168175367	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5280646	168175367	12739893	252	3975										
TLX3	30012	broad.mit.edu	37	chr5	170736467	170736467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccggaccaggacagcgcacCcgccccgcggggccccgacg	14	21	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:170736467C>T	uc003mbf.2	+	1	180	c.98C>T	c.(97-99)CCC>CTC	p.P33L	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	33						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GACAGCGCACCCGCCCCGCGG	0.751			T	BCL11B	T-ALL								0	0	0	0.004672	0	3	12										T	170736467	C	T	170736467	3	4	16	1	0	0	0	0	1	0	0	0	15959	623	22	2	100	2	TLX3	5	170736467	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2561100	170736467	10178793	253	3976										
RPL26L1	51121	broad.mit.edu	37	chr5	172386963	172386963	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcacacgtgcgcaggaagatCatgtcatccccgctctccaa	8	15	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:172386963C>T	uc003mcc.2	+	2	129	c.87C>T	c.(85-87)ATC>ATT	p.I29I	LOC100268168_uc011dfb.1_5'Flank|LOC100268168_uc011dfc.1_5'Flank	NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	29					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCAGGAAGATCATGTCATCCC	0.577													0	0	0	0.003271	0	31	87										T	172386963	C	T	172386963	2	4	16	1	0	0	0	0	0	0	0	1	13574	816	29	1		1	RPL26L1	5	172386963	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1650496	172386963	8528297	254	3977										
RGS14	10636	broad.mit.edu	37	chr5	176798587	176798587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agcggcagacctgtgacatcGaaggtacatggtggatgagc	15	8	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:176798587G>A	uc003mgf.2	+	14	1677	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K	RGS14_uc003mgh.2_Missense_Mutation_p.E347K|RGS14_uc003mgi.2_Missense_Mutation_p.E270K|RGS14_uc003mgj.2_RNA	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	499	GoLoco.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGTGACATCGAAGGTACATG	0.587													0	0	0	0.00623	0	40	58										A	176798587	G	A	176798587	3	1	16	1	0	0	0	0	1	0	0	0	13297	1059	37	1	1549	1	RGS14	5	176798587	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4411624	176798587	4116673	255	3978										
F12	2161	broad.mit.edu	37	chr5	176831015	176831015	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgggtcatcgaagacagactCttgcggagccgctgcccgca	13	14	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:176831015C>T	uc003mgo.3	-	10	1144	c.1095G>A	c.(1093-1095)AAG>AAA	p.K365K	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	365					Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGACAGACTCTTGCGGAGCC	0.701									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	8	31										T	176831015	C	T	176831015	2	4	16	1	0	0	0	0	0	0	0	1	5339	912	32	1		1	F12	5	176831015	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	32428	176831015	4084245	256	3979										
MAML1	9794	broad.mit.edu	37	chr5	179195951	179195951	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcccacaacagctccccctAtctcagcagccagcaacagg	6	19	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:179195951A>G	uc003mkm.2	+	3	2095	c.1832A>G	c.(1831-1833)TAT>TGT	p.Y611C	MAML1_uc003mkn.1_Missense_Mutation_p.Y611C	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	611					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTCCCCCTATCTCAGCAGC	0.572													0	0	0	0.01441	0	55	83										G	179195951	A	G	179195951	3	3	16	1	0	0	0	0	1	0	0	0	9205	449	16	5	1842	5	MAML1	5	179195951	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2364936	179195951	1719309	257	3980										
TRIM41	90933	broad.mit.edu	37	chr5	180660709	180660709	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaccccatagccatgacttcCtgacagatgccatcgtgagg	9	13	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:180660709C>T	uc003mne.1	+	5	1931	c.1237C>T	c.(1237-1239)CTG>TTG	p.L413L	TRIM41_uc003mnc.1_3'UTR|TRIM41_uc003mnd.1_Silent_p.L413L|TRIM41_uc003mnf.1_RNA|TRIM41_uc003mng.1_5'UTR	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	413	B30.2/SPRY.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCATGACTTCCTGACAGATGC	0.602													0	0	0	0.004007	0	15	51										T	180660709	C	T	180660709	2	4	16	1	0	0	0	0	0	0	0	1	16513	680	24	2		2	TRIM41	5	180660709	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1464758	180660709	254551	258	3981										
PHACTR1	221692	broad.mit.edu	37	chr6	13206114	13206114	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctccgctacctccaaagaaAgtcatgatctgtatgcccgt	7	14	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:13206114A>G	uc010jpc.2	+	8	1064	c.732A>G	c.(730-732)AAA>AAG	p.K244K	PHACTR1_uc011dir.1_Silent_p.K313K|PHACTR1_uc003nag.1_Silent_p.K244K|PHACTR1_uc003nah.1_Silent_p.K244K	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	244						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTCCAAAGAAAGTCATGATCT	0.592													0	0	0	0.010818	0	28	33										G	13206114	A	G	13206114	2	3	16	1	0	0	0	0	0	0	0	1	11809	69	3	5		5	PHACTR1	6	13206114	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08		13206114	157908953	259	3982										
PPP1R10	5514	broad.mit.edu	37	chr6	30569384	30569384	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggcacagttgttctcatagCggcagttgcccttcatcatg	10	11	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:30569384C>T	uc003nqn.1	-	20	3317	c.2765G>A	c.(2764-2766)CGC>CAC	p.R922H	PPP1R10_uc010jsc.1_Missense_Mutation_p.R576H	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	922	C3H1-type.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GTTCTCATAGCGGCAGTTGCC	0.552													0	0	0	0.00245	0	12	14										T	30569384	C	T	30569384	3	4	16	1	0	0	0	0	1	0	0	0	12352	768	27	2	61	2	PPP1R10	6	30569384	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	17363270	30569384	140545683	260	3983										
VARS2	57176	broad.mit.edu	37	chr6	30884903	30884903	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctcctcagtggctgtgactGaagcttttgtgcggctctac	12	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:30884903G>A	uc003nsc.1	+	8	1407	c.775G>A	c.(775-777)GAA>AAA	p.E259K	VARS2_uc003nsd.2_Missense_Mutation_p.E259K|VARS2_uc011dmx.1_Missense_Mutation_p.E259K|VARS2_uc011dmy.1_Missense_Mutation_p.E119K|VARS2_uc011dmz.1_Missense_Mutation_p.E289K|VARS2_uc011dna.1_Missense_Mutation_p.E259K|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'Flank|VARS2_uc010jsg.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	259					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GGCTGTGACTGAAGCTTTTGT	0.547													0	0	0	0.011902	0	43	37										A	30884903	G	A	30884903	3	1	16	1	0	0	0	0	1	0	0	0	17121	1291	45	1	899	1	VARS2	6	30884903	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	315519	30884903	140230164	261	3984										
C6orf47	57827	broad.mit.edu	37	chr6	31627076	31627076	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagtaggccatgtagccagaGgcccagcggtccacgcaggc	14	14	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:31627076G>C	uc003nvm.1	-	1	1474	c.649C>G	c.(649-651)CTC>GTC	p.L217V		NM_021184	NP_067007	O95873	CF047_HUMAN	G4 protein	217										ovary(1)	1						TGTAGCCAGAGGCCCAGCGGT	0.637													0	0	0	0.00499	0	16	18										C	31627076	G	C	31627076	3	2	16	1	0	0	0	0	1	0	0	0	2364	1000	35	4	239	4	C6orf47	6	31627076	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	742173	31627076	139487991	262	3985										
HLA-DQB1	3119	broad.mit.edu	37	chr6	32632653	32632653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caactccgcccgggtcccctCcaggacttccttctggctgt	9	18	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:32632653C>T	uc003obw.2	-	2	383	c.301G>A	c.(301-303)GAG>AAG	p.E101K	HLA-DQB1_uc010juc.1_Missense_Mutation_p.E56K|HLA-DQB1_uc003obv.2_Missense_Mutation_p.E101K|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.E101K|HLA-DQB1_uc011dqe.1_Missense_Mutation_p.E101K	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	101	Extracellular (Potential).|Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGGGTCCCCTCCAGGACTTCC	0.672									Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				0	0	0	0.008291	0	3	3										T	32632653	C	T	32632653	3	4	16	1	0	0	0	0	1	0	0	0	7206	864	30	1	500	1	HLA-DQB1	6	32632653	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1005577	32632653	138482414	263	3986										
TAP1	6890	broad.mit.edu	37	chr6	32815407	32815407	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccataggcaatattttcttGaagacttcttccaaatacct	5	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:32815407G>A	uc003ocg.2	-	9	2121	c.1966C>T	c.(1966-1968)CAA>TAA	p.Q656*	PSMB8_uc003ocf.2_5'Flank|TAP1_uc011dqi.1_Nonsense_Mutation_p.Q395*	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	656	Cytoplasmic (Potential).|ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						ATATTTTCTTGAAGACTTCTT	0.468													0	0	0	0.006122	0	17	25										A	32815407	G	A	32815407	4	1	16	1	0	0	0	0	0	1	0	0	15547	1299	45	1	472	1	TAP1	6	32815407	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	182754	32815407	138299660	264	3987										
HLA-DMB	3109	broad.mit.edu	37	chr6	32908579	32908579	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agcagcagcggcaggaatgtGatcatgctctgctctgtaaa	12	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:32908579G>A	uc003ocl.1	-	1	239	c.6C>T	c.(4-6)ATC>ATT	p.I2I	HLA-DMB_uc003ocj.1_Silent_p.I2I|HLA-DMB_uc011dql.1_Silent_p.I2I	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	2					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						GCAGGAATGTGATCATGCTCT	0.622													0	0	0	0.004672	0	3	6										A	32908579	G	A	32908579	2	1	16	1	0	0	0	0	0	0	0	1	7199	1280	45	1		1	HLA-DMB	6	32908579	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	93172	32908579	138206488	265	3988										
ZBTB22	9278	broad.mit.edu	37	chr6	33284074	33284074	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actccctggggctgaagtagTtgctgctgctgggagattga	15	8	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:33284074T>C	uc003oeb.2	-	2	772	c.620A>G	c.(619-621)AAC>AGC	p.N207S	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.N207S	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCTGAAGTAGTTGCTGCTGCT	0.627													0	0	0	0.006122	0	19	17										C	33284074	T	C	33284074	3	2	16	1	0	0	0	0	1	0	0	0	17527	1725	60	5	1288	5	ZBTB22	6	33284074	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	375495	33284074	137830993	266	3989										
KIFC1	3833	broad.mit.edu	37	chr6	33371898	33371898	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gactgatgtcccaactagagGagaaggaggtaagggccaga	15	7	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:33371898G>A	uc003oef.3	+	6	1198	c.748G>A	c.(748-750)GAG>AAG	p.E250K	KIFC1_uc011drf.1_Missense_Mutation_p.E242K	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	250	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CCAACTAGAGGAGAAGGAGGT	0.572													0	0	0	0.004007	0	14	16										A	33371898	G	A	33371898	3	1	16	1	0	0	0	0	1	0	0	0	8312	1175	41	1	770	1	KIFC1	6	33371898	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	87824	33371898	137743169	267	3990										
C6orf222	389384	broad.mit.edu	37	chr6	36287385	36287385	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttaaagctggggtggcgcctGatctggaagtggaaatgaaa	15	5	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:36287385G>A	uc003oly.2	-	11	1849	c.1671C>T	c.(1669-1671)ATC>ATT	p.I557I		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	557										skin(2)|ovary(1)|breast(1)	4						GGTGGCGCCTGATCTGGAAGT	0.582													0	0	0	0.012319	0	19	34										A	36287385	G	A	36287385	2	1	16	1	0	0	0	0	0	0	0	1	2356	1280	45	1		1	C6orf222	6	36287385	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2915487	36287385	134827682	268	3991										
ROS1	6098	broad.mit.edu	37	chr6	117631384	117631384	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtccaaagtctccaatcttCactatccgtggactggtata	7	11	3	0	rs148504976		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:117631384C>A	uc003pxp.1	-	40	6493	c.6294G>T	c.(6292-6294)GTG>GTT	p.V2098V	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2098	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V2098V(1)		lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTCCAATCTTCACTATCCGTG	0.408			T	GOPC|ROS1	glioblastoma|NSCLC								1	0	1.51943e-15	0.01441	1.63514e-15	45	37										A	117631384	C	A	117631384	2	1	16	1	0	0	0	0	0	0	0	1	13531	813	29	3		3	ROS1	6	117631384	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	81343999	117631384	53483683	269	3992										
ROS1	6098	broad.mit.edu	37	chr6	117683996	117683996	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcattttccacttggtaataTaaatattctggggttctctg	8	7	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:117683996T>C	uc003pxp.1	-	21	3350	c.3151A>G	c.(3151-3153)ATA>GTA	p.I1051V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1051	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTTGGTAATATAAATATTCTG	0.348			T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.001855	0	14	11										C	117683996	T	C	117683996	3	2	16	1	0	0	0	0	1	0	0	0	13531	1406	49	5	3984	5	ROS1	6	117683996	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	52612	117683996	53431071	270	3993										
TRMT11	60487	broad.mit.edu	37	chr6	126320655	126320655	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atacagtgtcaaaaagagacActttattggaaatacaagta	7	5	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:126320655A>G	uc003qam.2	+	7	696	c.575A>G	c.(574-576)CAC>CGC	p.H192R	TRMT11_uc003qan.2_RNA|TRMT11_uc010kev.2_Missense_Mutation_p.H192R	NM_001031712	NP_001026882	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11	192					tRNA processing		methyltransferase activity|nucleic acid binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0356)		AAAAAGAGACACTTTATTGGA	0.338													0	0	0	0.010818	0	32	16										G	126320655	A	G	126320655	3	3	16	1	0	0	0	0	1	0	0	0	16559	159	6	5	601	5	TRMT11	6	126320655	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	8636659	126320655	44794412	271	3994										
SAMD3	154075	broad.mit.edu	37	chr6	130465682	130465682	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctattaagtgagtgggtgctGaaatcctacttcgttttcct	9	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:130465682G>T	uc003qbv.2	-	13	1872	c.1546C>A	c.(1546-1548)CAG>AAG	p.Q516K	SAMD3_uc003qbx.2_Missense_Mutation_p.Q516K|SAMD3_uc003qbw.2_Missense_Mutation_p.Q516K	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	516										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AGTGGGTGCTGAAATCCTACT	0.368													1	0	3.07112e-06	0.010729	3.20885e-06	9	26										T	130465682	G	T	130465682	3	4	16	1	0	0	0	0	1	0	0	0	13820	1299	45	3	20	3	SAMD3	6	130465682	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4145027	130465682	40649385	272	3995										
EPB41L2	2037	broad.mit.edu	37	chr6	131216209	131216209	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgcagtctgtctttgtaaatGagaagtccattagcacacac	8	10	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:131216209G>C	uc003qch.2	-	9	1469	c.1287C>G	c.(1285-1287)CTC>CTG	p.L429L	EPB41L2_uc003qcg.1_Silent_p.L429L|EPB41L2_uc011eby.1_Silent_p.L429L|EPB41L2_uc003qci.2_Silent_p.L429L|EPB41L2_uc010kfk.2_Silent_p.L429L|EPB41L2_uc010kfl.1_Silent_p.L429L	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	429	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CTTTGTAAATGAGAAGTCCAT	0.423													0	0	0	0.01441	0	49	34										C	131216209	G	C	131216209	2	2	16	1	0	0	0	0	0	0	0	1	5153	1277	45	1		1	EPB41L2	6	131216209	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	750527	131216209	39898858	273	3996										
UTRN	7402	broad.mit.edu	37	chr6	144898326	144898326	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acttcctgaagtggatccaaGaagcagagaccacagtgaat	10	9	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:144898326G>A	uc003qkt.2	+	50	7473	c.7381G>A	c.(7381-7383)GAA>AAA	p.E2461K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2461	Spectrin 17.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GTGGATCCAAGAAGCAGAGAC	0.512													0	0	0	0.014323	0	22	20										A	144898326	G	A	144898326	3	1	16	1	0	0	0	0	1	0	0	0	17100	943	33	1	7579	1	UTRN	6	144898326	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	13682117	144898326	26216741	274	3997										
TIAM2	26230	broad.mit.edu	37	chr6	155561805	155561805	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagaccgcctccgcaaagtcAtccaggagcttgtggacaca	10	14	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:155561805A>G	uc003qqb.2	+	18	4583	c.3310A>G	c.(3310-3312)ATC>GTC	p.I1104V	TIAM2_uc003qqe.2_Missense_Mutation_p.I1104V|TIAM2_uc010kjj.2_Missense_Mutation_p.I637V|TIAM2_uc003qqf.2_Missense_Mutation_p.I480V|TIAM2_uc011efl.1_Missense_Mutation_p.I440V|TIAM2_uc003qqg.2_Missense_Mutation_p.I416V|TIAM2_uc003qqh.2_Missense_Mutation_p.I29V	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1104	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCGCAAAGTCATCCAGGAGCT	0.567													0	0	0	0.008871	0	16	24										G	155561805	A	G	155561805	3	3	16	1	0	0	0	0	1	0	0	0	15888	217	8	5	3360	5	TIAM2	6	155561805	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	10663479	155561805	15553262	275	3998										
SERAC1	84947	broad.mit.edu	37	chr6	158565401	158565401	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctcttcgcttcgtgccaaaCcaataagagttttcggatca	7	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:158565401C>T	uc003qrc.2	-	7	681	c.539G>A	c.(538-540)GGT>GAT	p.G180D	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	180					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		TCGTGCCAAACCAATAAGAGT	0.343													0	0	0	0.007413	0	18	19										T	158565401	C	T	158565401	3	4	16	1	0	0	0	0	1	0	0	0	14074	507	18	2	1469	2	SERAC1	6	158565401	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3003596	158565401	12549666	276	3999										
WDR27	253769	broad.mit.edu	37	chr6	170047876	170047876	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggacgtggcgcacctgagtaCtggatgcagcatacacgtgt	14	10	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:170047876C>G	uc003qwx.2	-	16	2170	c.1650G>C	c.(1648-1650)CAG>CAC	p.Q550H	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Missense_Mutation_p.Q550H|WDR27_uc003qwy.2_Missense_Mutation_p.Q423H			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	520	WD 5.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CACCTGAGTACTGGATGCAGC	0.562													0	0	0	0.009096	0	4	2										G	170047876	C	G	170047876	3	3	16	1	0	0	0	0	1	0	0	0	17281	564	20	4	963	4	WDR27	6	170047876	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	11482475	170047876	1067191	277	4000										
DLL1	28514	broad.mit.edu	37	chr6	170597489	170597489	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcggtaggagtacttgaggtCcgtgcggccgctgctgtgca	17	10	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:170597489C>T	uc003qxm.2	-	4	978	c.508G>A	c.(508-510)GAC>AAC	p.D170N	DLL1_uc011ehc.1_Missense_Mutation_p.D170N	NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	170	Extracellular (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TACTTGAGGTCCGTGCGGCCG	0.627													0	0	0	0.014323	0	21	21										T	170597489	C	T	170597489	3	4	16	1	0	0	0	0	1	0	0	0	4566	855	30	1	1695	1	DLL1	6	170597489	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	549613	170597489	517578	278	4001										
EIF3B	8662	broad.mit.edu	37	chr7	2400441	2400441	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccctcaggtgggacccgaccGacttgagaaactcaaaaatg	10	12	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:2400441G>A	uc003slx.2	+	2	679	c.596G>A	c.(595-597)CGA>CAA	p.R199Q	EIF3B_uc003sly.2_Missense_Mutation_p.R199Q|EIF3B_uc003slz.1_Missense_Mutation_p.R160Q|EIF3B_uc003sma.2_5'UTR	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	199	Sufficient for interaction with EIF3E.|RRM.|Sufficient for interaction with EIF3J.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GGACCCGACCGACTTGAGAAA	0.443													0	0	0	0.012319	0	22	45										A	2400441	G	A	2400441	3	1	16	1	0	0	0	0	1	0	0	0	5013	1058	37	1	602	1	EIF3B	7	2400441	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		2400441	156738222	279	4002										
SLC29A4	222962	broad.mit.edu	37	chr7	5338755	5338755	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcgcagctggcccaccttcaGaggtgagtgcggggagtcct	16	12	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:5338755G>A	uc003sod.2	+	8	1180	c.1019G>A	c.(1018-1020)AGA>AAA	p.R340K	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.R340K|SLC29A4_uc003soe.2_Missense_Mutation_p.R326K|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	340	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CCCACCTTCAGAGGTGAGTGC	0.721													0	0	0	0.00308	0	7	20										A	5338755	G	A	5338755	3	1	16	1	0	0	0	0	1	0	0	0	14537	942	33	1	1045	1	SLC29A4	7	5338755	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2938314	5338755	153799908	280	4003										
RNF216	54476	broad.mit.edu	37	chr7	5760771	5760771	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgtcgtcgcttattttcaaGaaagaacatcctcttttcta	5	9	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:5760771G>A	uc003soy.1	-	9	1556	c.1366C>T	c.(1366-1368)CTT>TTT	p.L456F	RNF216_uc010ksz.1_Missense_Mutation_p.L78F|RNF216_uc010kta.1_Missense_Mutation_p.L78F|RNF216_uc011jwj.1_Missense_Mutation_p.L78F|RNF216_uc003sox.1_Missense_Mutation_p.L513F	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	456					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TTATTTTCAAGAAAGAACATC	0.428													0	0	0	0.00278	0	23	49										A	5760771	G	A	5760771	3	1	16	1	0	0	0	0	1	0	0	0	13480	942	33	1	1270	1	RNF216	7	5760771	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	422016	5760771	153377892	281	4004										
DNAH11	8701	broad.mit.edu	37	chr7	21639522	21639522	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctataatgcacgacttagacTtctttctgaagaatacagag	7	8	2	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:21639522T>A	uc003svc.2	+	15	2816	c.2785T>A	c.(2785-2787)TTC>ATC	p.F929I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	929	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CGACTTAGACTTCTTTCTGAA	0.398									Kartagener_syndrome				0	0	0	0.000602	0	5	32										A	21639522	T	A	21639522	3	1	16	1	0	0	0	0	1	0	0	0	4599	1609	56	5	2843	5	DNAH11	7	21639522	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	15878751	21639522	137499141	282	4005										
NFE2L3	9603	broad.mit.edu	37	chr7	26223328	26223340	+	Frame_Shift_Del	DEL	TGAATGGGACAGA	TGAATGGGACAGA	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgtttctctacagagacatcTgaatgggacagatacttctt					rs150480522		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:26223328_26223340delTGAATGGGACAGA	uc003sxq.2	+	3	1030_1042	c.758_770delTGAATGGGACAGA	c.(757-771)CTGAATGGGACAGATfs	p.L253fs		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	253_257					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						CAGAGACATCTGAATGGGACAGATACTTCTTTC	0.394																		11	69	---	---								-	26223340	TGAATGGGACAGA	-	26223328	7	5	16	1	0	1	0	1	0	0	0	0	10369	1580	55	0	768	0	NFE2L3	7	26223328	Frame_Shift_Del	DEL	TGAATGGGACAGA	TCGA-BT-A2LB-01A-11D-A18F-08	4583806	26223328	132915335	283	4006										
TRIL	9865	broad.mit.edu	37	chr7	28996568	28996568	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgcttcaggcctcgcagccgGcagtcgcaggtccagccgtt	13	16	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:28996568G>A	uc003szt.2	-	3	1462	c.1095C>T	c.(1093-1095)TGC>TGT	p.C365C	uc003szu.1_5'Flank	NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	365	Extracellular (Potential).|LRRCT.				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0						CTCGCAGCCGGCAGTCGCAGG	0.687													0	0	0	0.009096	0	4	10										A	28996568	G	A	28996568	2	1	16	1	0	0	0	0	0	0	0	1	16482	1195	42	2		2	TRIL	7	28996568	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2773240	28996568	130142095	284	4007										
NEUROD6	63974	broad.mit.edu	37	chr7	31378784	31378784	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgtttggaaaagctttctggCttcttaatttgcttctggtc	9	7	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:31378784C>A	uc003tch.2	-	2	452	c.99G>T	c.(97-99)AAG>AAT	p.K33N		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	33					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						AGCTTTCTGGCTTCTTAATTT	0.343													1	0	2.24893e-16	0.009718	2.42626e-16	44	110										A	31378784	C	A	31378784	3	1	16	1	0	0	0	0	1	0	0	0	10351	796	28	4	918	4	NEUROD6	7	31378784	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2382216	31378784	127759879	285	4008										
SFRP4	6424	broad.mit.edu	37	chr7	37947153	37947153	+	Frame_Shift_Del	DEL	G	G	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcttgggactggctggtttGggagcaggaggctttccctt							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:37947153delG	uc003tfo.3	-	6	1355	c.969delC	c.(967-969)CCCfs	p.P323fs		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	323					brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TGGCTGGTTTGGGAGCAGGAG	0.512																		45	121	---	---								-	37947153	G	-	37947153	7	5	16	1	0	1	0	1	0	0	0	0	14163	1335	47	0	75	0	SFRP4	7	37947153	Frame_Shift_Del	DEL	G	TCGA-BT-A2LB-01A-11D-A18F-08	6568369	37947153	121191510	286	4009										
TMED4	222068	broad.mit.edu	37	chr7	44620691	44620691	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tacaaggagatatgcacttgCcctttggtaatcctgctcct	8	11	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:44620691C>T	uc003tli.2	-	4	556	c.534_splice	c.e4+1	p.R178_splice	TMED4_uc003tlj.2_Missense_Mutation_p.A120T|TMED4_uc003tlk.2_Missense_Mutation_p.A179T|uc003tll.2_5'Flank	NM_182547	NP_872353	Q7Z7H5	TMED4_HUMAN	transmembrane emp24 protein transport domain						positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity				0						TATGCACTTGCCCTTTGGTAA	0.483													0	0	0	0.007413	0	17	43										T	44620691	C	T	44620691	5	4	16	1	0	0	0	0	0	0	1	0	16003	753	26	2	156	2	TMED4	7	44620691	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6673538	44620691	114517972	287	4010										
OGDH	4967	broad.mit.edu	37	chr7	44739760	44739760	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaccttaaagaagccaacttCgacatcaatcagctatatga	6	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:44739760C>T	uc003tln.2	+	19	2560	c.2451C>T	c.(2449-2451)TTC>TTT	p.F817F	OGDH_uc011kbx.1_Silent_p.F813F|OGDH_uc011kby.1_Silent_p.F667F|OGDH_uc003tlp.2_Silent_p.F828F|OGDH_uc011kbz.1_Silent_p.F612F	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	817					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	AAGCCAACTTCGACATCAATC	0.532													0	0	0	0.007835	0	39	69										T	44739760	C	T	44739760	2	4	16	1	0	0	0	0	0	0	0	1	10839	883	31	1		1	OGDH	7	44739760	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	119069	44739760	114398903	288	4011										
TYW1B	441250	broad.mit.edu	37	chr7	72277753	72277753	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attcacatttgcctttcttgCagtggccgccacaggacttc	8	13	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:72277753C>T	uc011kej.1	-	5	788	c.629G>A	c.(628-630)TGC>TAC	p.C210Y	TYW1B_uc011keh.1_Intron|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	210					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GCCTTTCTTGCAGTGGCCGCC	0.517													0	0	0	0.00308	0	8	20										T	72277753	C	T	72277753	3	4	16	1	0	0	0	0	1	0	0	0	16816	710	25	2	1539	2	TYW1B	7	72277753	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	27537993	72277753	86860910	289	4012										
WBSCR27	155368	broad.mit.edu	37	chr7	73255423	73255423	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcagccactaggcctgtgcCacaggccacgtccaggatca	12	15	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:73255423C>T	uc003tzj.2	-	3	269	c.229G>A	c.(229-231)GGC>AGC	p.G77S	RFC2_uc011kfa.1_Intron|WBSCR27_uc011kfd.1_Missense_Mutation_p.G77S	NM_152559	NP_689772	Q8N6F8	WBS27_HUMAN	Williams-Beuren syndrome chromosome region 27	77										central_nervous_system(1)	1		Lung NSC(55;0.159)				AGGCCTGTGCCACAGGCCACG	0.662													0	0	0	0.000602	0	5	13										T	73255423	C	T	73255423	3	4	16	1	0	0	0	0	1	0	0	0	17263	594	21	2	524	2	WBSCR27	7	73255423	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	977670	73255423	85883240	290	4013										
PTPN12	5782	broad.mit.edu	37	chr7	77230076	77230076	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggacatgataagcttaatGaggaaatatcaagaacatga	9	5	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:77230076G>A	uc003ugh.2	+	8	739	c.648G>A	c.(646-648)ATG>ATA	p.M216I	PTPN12_uc011kgp.1_Missense_Mutation_p.M97I|PTPN12_uc011kgq.1_Missense_Mutation_p.M86I	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	216	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						TAAGCTTAATGAGGAAATATC	0.328													0	0	0	0.004672	0	3	25										A	77230076	G	A	77230076	3	1	16	1	0	0	0	0	1	0	0	0	12781	1290	45	1	678	1	PTPN12	7	77230076	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3974653	77230076	81908587	291	4014										
CD36	948	broad.mit.edu	37	chr7	80301250	80301250	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtcttcagggagacctgtgtAcatttcacttcctcattttc	7	11	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:80301250A>G	uc003uhc.2	+	14	1703	c.1019A>G	c.(1018-1020)TAC>TGC	p.Y340C	CD36_uc003uhd.3_Missense_Mutation_p.Y340C|CD36_uc011kgv.1_Missense_Mutation_p.Y264C|CD36_uc003uhe.3_Missense_Mutation_p.Y340C|CD36_uc003uhf.3_Missense_Mutation_p.Y340C|CD36_uc003uhg.3_Missense_Mutation_p.Y340C|CD36_uc003uhh.3_Missense_Mutation_p.Y340C	NM_001127444	NP_001120916	P16671	CD36_HUMAN	CD36 antigen	340	Extracellular (Potential).				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1						AGACCTGTGTACATTTCACTT	0.328													0	0	0	0.008291	0	10	41										G	80301250	A	G	80301250	3	3	16	1	0	0	0	0	1	0	0	0	3007	391	14	5	1053	5	CD36	7	80301250	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3071174	80301250	78837413	292	4015										
SEMA3A	10371	broad.mit.edu	37	chr7	83823856	83823856	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatagtttgctcttgctgtaAgtaatactccccagaaaaga	8	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:83823856A>C	uc003uhz.2	-	1	362	c.47T>G	c.(46-48)CTT>CGT	p.L16R		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	16					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TCTTGCTGTAAGTAATACTCC	0.408													0	0	0	0.007291	0	25	77										C	83823856	A	C	83823856	3	2	16	1	0	0	0	0	1	0	0	0	14024	72	3	5	2336	5	SEMA3A	7	83823856	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3522606	83823856	75314807	293	4016										
SEMA3D	223117	broad.mit.edu	37	chr7	84649547	84649547	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcactctggactgagtcttAccttgaatatctgcaactcc	8	12	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:84649547A>G	uc003uic.2	-	12	1543	c.1503_splice	c.e12+1	p.K501_splice	SEMA3D_uc010led.2_Splice_Site_p.K501_splice|SEMA3D_uc003uib.2_Splice_Site_p.K140_splice	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						ACTGAGTCTTACCTTGAATAT	0.413													0	0	0	0.001168	0	6	28										G	84649547	A	G	84649547	5	3	16	1	0	0	0	0	0	0	1	0	14027	405	14	5	852	5	SEMA3D	7	84649547	Splice_Site	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	825691	84649547	74489116	294	4017										
CYP3A4	1576	broad.mit.edu	37	chr7	99358539	99358539	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acctcatgccaatgcagtttCtgggtccacttccaaagggt	9	12	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:99358539C>T	uc003urv.1	-	12	1423	c.1319G>A	c.(1318-1320)AGA>AAA	p.R440K	CYP3A4_uc003urw.1_Missense_Mutation_p.R439K|CYP3A4_uc011kiz.1_Missense_Mutation_p.R399K|CYP3A4_uc011kja.1_Missense_Mutation_p.R391K|CYP3A4_uc011kjb.1_Missense_Mutation_p.R290K	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	440					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	AATGCAGTTTCTGGGTCCACT	0.393													0	0	0	0.01441	0	44	68										T	99358539	C	T	99358539	3	4	16	1	0	0	0	0	1	0	0	0	4178	913	32	1	200	1	CYP3A4	7	99358539	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	14708992	99358539	59780124	295	4018										
CYP3A4	1576	broad.mit.edu	37	chr7	99359668	99359668	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccaggggccttgtacctttCagggaggaacttctcaggct	12	12	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:99359668C>G	uc003urv.1	-	11	1353	c.1249G>C	c.(1249-1251)GAA>CAA	p.E417Q	CYP3A4_uc003urw.1_Missense_Mutation_p.E416Q|CYP3A4_uc011kiz.1_Missense_Mutation_p.E376Q|CYP3A4_uc011kja.1_Missense_Mutation_p.E368Q|CYP3A4_uc011kjb.1_Missense_Mutation_p.E267Q	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	417					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTGTACCTTTCAGGGAGGAAC	0.507													0	0	0	0.00632	0	25	91										G	99359668	C	G	99359668	3	3	16	1	0	0	0	0	1	0	0	0	4178	835	29	1	274	1	CYP3A4	7	99359668	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1129	99359668	59778995	296	4019										
OR2AE1	81392	broad.mit.edu	37	chr7	99473945	99473945	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaggtgggagccacaagtggCaaaggcatttctcttgctcc	13	10	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:99473945C>G	uc003usc.1	-	1	712	c.712G>C	c.(712-714)GCC>CCC	p.A238P		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCACAAGTGGCAAAGGCATTT	0.498													0	0	0	0.004482	0	8	35										G	99473945	C	G	99473945	3	3	16	1	0	0	0	0	1	0	0	0	10983	710	25	4	263	4	OR2AE1	7	99473945	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	114277	99473945	59664718	297	4020										
MUC17	140453	broad.mit.edu	37	chr7	100684143	100684143	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccattcatctcctacaacttCtgaaggtaccagcatgccaa	5	14	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:100684143C>T	uc003uxp.1	+	3	9499	c.9446C>T	c.(9445-9447)TCT>TTT	p.S3149F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3149	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|51.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTACAACTTCTGAAGGTACC	0.488													0	0	0	0.01441	0	68	311										T	100684143	C	T	100684143	3	4	16	1	0	0	0	0	1	0	0	0	9974	913	32	1	9456	1	MUC17	7	100684143	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1210198	100684143	58454520	298	4021										
LAMB1	3912	broad.mit.edu	37	chr7	107594021	107594021	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccatagtatccaaaccggcaGaactgacagtgttccccttc	7	14	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:107594021G>A	uc003vew.2	-	22	3368	c.3033C>T	c.(3031-3033)TTC>TTT	p.F1011F	LAMB1_uc003vev.2_Silent_p.F1035F	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1011	Laminin EGF-like 10.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAACCGGCAGAACTGACAGT	0.493													0	0	0	0.01441	0	47	36										A	107594021	G	A	107594021	2	1	16	1	0	0	0	0	0	0	0	1	8610	933	33	1		1	LAMB1	7	107594021	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6909878	107594021	51544642	299	4022										
DOCK4	9732	broad.mit.edu	37	chr7	111541741	111541741	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtattaacataccttcagggTttggccactactgtctacaa	7	10	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:111541741T>C	uc003vfx.2	-	14	1578	c.1309A>G	c.(1309-1311)ACC>GCC	p.T437A	DOCK4_uc003vfy.2_Missense_Mutation_p.T437A|DOCK4_uc003vga.1_Missense_Mutation_p.T42A	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	437	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ACCTTCAGGGTTTGGCCACTA	0.358													0	0	0	0.008291	0	11	39										C	111541741	T	C	111541741	3	2	16	1	0	0	0	0	1	0	0	0	4689	1725	60	5	4747	5	DOCK4	7	111541741	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	3947720	111541741	47596922	300	4023										
AASS	10157	broad.mit.edu	37	chr7	121738842	121738842	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctcttgataaatattctaaTacaggctcagatatgtagcc	6	8	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:121738842T>C	uc003vka.2	-	13	1581	c.1485A>G	c.(1483-1485)GTA>GTG	p.V495V	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.V495V|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	495	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	AATATTCTAATACAGGCTCAG	0.328													0	0	0	0.013537	0	12	61										C	121738842	T	C	121738842	2	2	16	1	0	0	0	0	0	0	0	1	24	1393	49	5		5	AASS	7	121738842	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	10197101	121738842	37399821	301	4024										
PAX4	5078	broad.mit.edu	37	chr7	127251629	127251629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctttaggtggggtgtcactCagacacctttctggtgctgt	13	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:127251629C>T	uc010lld.1	-	8	1055	c.849G>A	c.(847-849)CTG>CTA	p.L283L	PAX4_uc003vmf.2_Silent_p.L281L|PAX4_uc003vmg.1_Silent_p.L283L	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	291	Transcription repression.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGTGTCACTCAGACACCTTT	0.607													0	0	0	0.008871	0	20	105										T	127251629	C	T	127251629	2	4	16	1	0	0	0	0	0	0	0	1	11481	813	29	1		1	PAX4	7	127251629	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5512787	127251629	31887034	302	4025										
PLXNA4	91584	broad.mit.edu	37	chr7	131853207	131853207	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggccacgttgccacggtcgCgcatggagaagctacgctgg	15	12	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:131853207C>T	uc003vra.3	-	22	4371	c.4142G>A	c.(4141-4143)CGC>CAC	p.R1381H		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1381	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GCCACGGTCGCGCATGGAGAA	0.582													0	0	0	0.004482	0	6	43										T	131853207	C	T	131853207	3	4	16	1	0	0	0	0	1	0	0	0	12122	768	27	2	1586	2	PLXNA4	7	131853207	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4601578	131853207	27285456	303	4026										
EXOC4	60412	broad.mit.edu	37	chr7	133622721	133622721	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccctccacaagacatccttcGtgacgtcagtgacctcaaag	7	15	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:133622721G>T	uc003vrk.2	+	14	2140	c.2105G>T	c.(2104-2106)CGT>CTT	p.R702L	EXOC4_uc011kpo.1_Missense_Mutation_p.R601L|EXOC4_uc003vrl.2_Missense_Mutation_p.R312L|EXOC4_uc011kpp.1_Missense_Mutation_p.R234L|EXOC4_uc011kpq.1_5'UTR	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	702					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GACATCCTTCGTGACGTCAGT	0.458													1	0	0.000673444	0.008291	0.000694388	11	78										T	133622721	G	T	133622721	3	4	16	1	0	0	0	0	1	0	0	0	5306	1145	40	4	2168	4	EXOC4	7	133622721	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1769514	133622721	25515942	304	4027										
WDR91	29062	broad.mit.edu	37	chr7	134894412	134894412	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatatatcctccaagcggctGaagagccgacgctccaagta	9	12	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:134894412G>A	uc003vsp.2	-	2	281	c.219C>T	c.(217-219)TTC>TTT	p.F73F	WDR91_uc010lmq.2_5'Flank|WDR91_uc010lmr.2_5'Flank	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	73										breast(2)|ovary(1)|skin(1)	4						CCAAGCGGCTGAAGAGCCGAC	0.493													0	0	0	0.01441	0	46	83										A	134894412	G	A	134894412	2	1	16	1	0	0	0	0	0	0	0	1	17335	1281	45	1		1	WDR91	7	134894412	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1271691	134894412	24244251	305	4028										
MLL3	58508	broad.mit.edu	37	chr7	151945668	151945668	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcaacttcattagaaatctgTttttccaattcagtattcac	3	9	5	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:151945668T>C	uc003wla.2	-	14	2070	c.1851A>G	c.(1849-1851)AAA>AAG	p.K617K		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	617					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TAGAAATCTGTTTTTCCAATT	0.308			N		medulloblastoma								0	0	0	0.009096	0	4	29										C	151945668	T	C	151945668	2	2	16	1	0	0	0	0	0	0	0	1	9622	1722	60	5		5	MLL3	7	151945668	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	17051256	151945668	7192995	306	4029										
ANGPT2	285	broad.mit.edu	37	chr8	6378704	6378704	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatatgtaaacttacagtttGatgtggacatcatagtcagt	9	5	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:6378704G>C	uc003wqj.3	-	4	1123	c.794C>G	c.(793-795)TCA>TGA	p.S265*	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Nonsense_Mutation_p.S265*|ANGPT2_uc010lri.2_Nonsense_Mutation_p.S213*|ANGPT2_uc003wql.3_Nonsense_Mutation_p.S265*	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	265					angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		CTTACAGTTTGATGTGGACAT	0.353													0	0	0	0.001984	0	6	26										C	6378704	G	C	6378704	4	2	16	1	0	0	0	0	0	1	0	0	611	1294	45	1	720	1	ANGPT2	8	6378704	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		6378704	139985318	307	4030										
MTUS1	57509	broad.mit.edu	37	chr8	17612302	17612302	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagacaataggacactgtctCtctcagattttggcccattt	7	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:17612302C>T	uc003wxv.2	-	2	1489	c.1015G>A	c.(1015-1017)GAG>AAG	p.E339K	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.E339K|MTUS1_uc010lsz.2_Missense_Mutation_p.E339K	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	339						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GACACTGTCTCTCTCAGATTT	0.423													0	0	0	0.004656	0	28	42										T	17612302	C	T	17612302	3	4	16	1	0	0	0	0	1	0	0	0	9965	922	32	1	3172	1	MTUS1	8	17612302	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	11233598	17612302	128751720	308	4031										
TNFRSF10C	8794	broad.mit.edu	37	chr8	22972236	22972236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gggtgtggattacaccaacgCttccaacaatgaaccttctt	8	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:22972236C>T	uc003xcy.2	+	3	434	c.233C>T	c.(232-234)GCT>GTT	p.A78V	TNFRSF10C_uc011kzr.1_RNA	NM_003841	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily,	78	TNFR-Cys 2.				apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TACACCAACGCTTCCAACAAT	0.483													0	0	0	0.003755	0	29	40										T	22972236	C	T	22972236	3	4	16	1	0	0	0	0	1	0	0	0	16279	797	28	2	243	2	TNFRSF10C	8	22972236	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5359934	22972236	123391786	309	4032										
FZD3	7976	broad.mit.edu	37	chr8	28413267	28413267	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgtctaggatagtgaatgaGagccgacaggtactccagga	13	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:28413267G>C	uc003xgx.2	+	7	2044	c.1566G>C	c.(1564-1566)GAG>GAC	p.E522D	FZD3_uc010lvb.2_Missense_Mutation_p.E522D	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	522	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TAGTGAATGAGAGCCGACAGG	0.393													0	0	0	0.001855	0	12	45										C	28413267	G	C	28413267	3	2	16	1	0	0	0	0	1	0	0	0	6131	933	33	1	1584	1	FZD3	8	28413267	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5441031	28413267	117950755	310	4033										
HMBOX1	79618	broad.mit.edu	37	chr8	28827975	28827975	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagcatgggtcagaggtcaTacagttttgaagcctcagaa	11	8	3	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:28827975T>C	uc003xhd.3	+	3	781	c.439T>C	c.(439-441)TAC>CAC	p.Y147H	HMBOX1_uc010lvd.2_Missense_Mutation_p.Y147H|HMBOX1_uc003xhc.3_Missense_Mutation_p.Y147H|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Missense_Mutation_p.Y147H|HMBOX1_uc011lay.1_Missense_Mutation_p.Y147H|HMBOX1_uc003xhf.2_Missense_Mutation_p.Y135H|HMBOX1_uc003xhg.2_Missense_Mutation_p.Y135H	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	147					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		TCAGAGGTCATACAGTTTTGA	0.403													0	0	0	0.001168	0	5	46										C	28827975	T	C	28827975	3	2	16	1	0	0	0	0	1	0	0	0	7218	1406	49	5	445	5	HMBOX1	8	28827975	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	414708	28827975	117536047	311	4034										
NRG1	3084	broad.mit.edu	37	chr8	32463142	32463142	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggagagtatatgtgcaaagTgatcagcaaattaggaaatg	12	3	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:32463142T>C	uc003xiv.2	+	3	858	c.341T>C	c.(340-342)GTG>GCG	p.V114A	NRG1_uc003xip.2_Missense_Mutation_p.V329A|NRG1_uc003xir.2_Missense_Mutation_p.V114A|NRG1_uc010lvl.2_Missense_Mutation_p.V114A|NRG1_uc010lvm.2_Missense_Mutation_p.V114A|NRG1_uc010lvn.2_Missense_Mutation_p.V114A|NRG1_uc003xis.2_Missense_Mutation_p.V114A|NRG1_uc011lbf.1_Missense_Mutation_p.V114A|NRG1_uc010lvo.2_Missense_Mutation_p.V114A|NRG1_uc003xiu.2_Missense_Mutation_p.V114A|NRG1_uc003xiw.2_Missense_Mutation_p.V114A|NRG1_uc003xit.2_Missense_Mutation_p.V114A|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Missense_Mutation_p.V80A|NRG1_uc010lvq.2_Missense_Mutation_p.V80A|NRG1_uc003xix.2_Missense_Mutation_p.V4A	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	114	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ATGTGCAAAGTGATCAGCAAA	0.408													0	0	0	0.00278	0	21	35										C	32463142	T	C	32463142	3	2	16	1	0	0	0	0	1	0	0	0	10647	1696	59	5	1102	5	NRG1	8	32463142	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	3635167	32463142	113900880	312	4035										
ADAM9	8754	broad.mit.edu	37	chr8	38928862	38928862	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttcattgaagtgaattctaAaggtgacagatttggcaatt	9	4	2	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:38928862A>G	uc003xmr.2	+	15	1715	c.1637A>G	c.(1636-1638)AAA>AGA	p.K546R	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA|ADAM9_uc003xms.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	546	Cys-rich.|Extracellular (Potential).				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			GTGAATTCTAAAGGTGACAGA	0.358													0	0	0	0.004007	0	14	17										G	38928862	A	G	38928862	3	3	16	1	0	0	0	0	1	0	0	0	253	14	1	5	1695	5	ADAM9	8	38928862	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	6465720	38928862	107435160	313	4036										
GOLGA7	51125	broad.mit.edu	37	chr8	41355114	41355114	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcggcggccagtcatatctCgaaggttgtttggcttgttt	12	9	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:41355114C>T	uc003xnu.2	+	3	276	c.198C>T	c.(196-198)CTC>CTT	p.L66L	GOLGA7_uc003xnv.2_RNA|GOLGA7_uc003xnw.2_Silent_p.L66L	NM_016099	NP_057183	Q7Z5G4	GOGA7_HUMAN	golgi autoantigen, golgin subfamily a, 7	66						Golgi membrane				breast(1)	1	Ovarian(28;0.014)|Colorectal(14;0.0234)|Lung SC(25;0.211)	all_lung(54;0.000771)|Lung NSC(58;0.0031)|Hepatocellular(245;0.014)|Esophageal squamous(32;0.0559)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00596)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGTCATATCTCGAAGGTTGTT	0.383													0	0	0	0.014323	0	21	112										T	41355114	C	T	41355114	2	4	16	1	0	0	0	0	0	0	0	1	6561	871	31	1		1	GOLGA7	8	41355114	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2426252	41355114	105008908	314	4037										
POTEA	340441	broad.mit.edu	37	chr8	43152200	43152200	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctgtgccaatggcaattcaGaagtagtaagtcttctgctg	10	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:43152200G>A	uc003xpz.1	+	2	380	c.337G>A	c.(337-339)GAA>AAA	p.E113K	POTEA_uc003xqa.1_Missense_Mutation_p.E113K	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	113	ANK 1.									ovary(1)	1						TGGCAATTCAGAAGTAGTAAG	0.408													0	0	0	0.001855	0	14	74										A	43152200	G	A	43152200	3	1	16	1	0	0	0	0	1	0	0	0	12261	943	33	1	343	1	POTEA	8	43152200	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1797086	43152200	103211822	315	4038										
NPBWR1	2831	broad.mit.edu	37	chr8	53853103	53853103	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tacacgctcgtgctgggcttCgccatccccgtgtccaccat	9	17	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:53853103C>T	uc011ldu.1	+	1	636	c.636C>T	c.(634-636)TTC>TTT	p.F212F		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	212	Helical; Name=5; (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				TGCTGGGCTTCGCCATCCCCG	0.682													0	0	0	0.001984	0	7	10										T	53853103	C	T	53853103	2	4	16	1	0	0	0	0	0	0	0	1	10568	883	31	1		1	NPBWR1	8	53853103	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	10700903	53853103	92510919	316	4039										
SDR16C5	195814	broad.mit.edu	37	chr8	57228775	57228775	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccacttccagcacctgtgatGaggactatttcaccagcaac	7	14	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:57228775G>A	uc003xsy.1	-	2	770	c.132C>T	c.(130-132)CTC>CTT	p.L44L	SDR16C5_uc010lyk.1_Silent_p.L44L|SDR16C5_uc010lyl.1_Silent_p.L44L	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	44	NAD or NADP (By similarity).				detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CACCTGTGATGAGGACTATTT	0.468													0	0	0	0.001984	0	7	41										A	57228775	G	A	57228775	2	1	16	1	0	0	0	0	0	0	0	1	13971	1277	45	1		1	SDR16C5	8	57228775	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3375672	57228775	89135247	317	4040										
CHD7	55636	broad.mit.edu	37	chr8	61655515	61655515	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctggtcaacagccatctttTcagcagttgccaacctgtcc	7	15	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:61655515T>C	uc003xue.2	+	2	2001	c.1524T>C	c.(1522-1524)TTT>TTC	p.F508F		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	508	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGCCATCTTTTCAGCAGTTGC	0.572													0	0	0	0.009096	0	3	17										C	61655515	T	C	61655515	2	2	16	1	0	0	0	0	0	0	0	1	3330	1780	62	5		5	CHD7	8	61655515	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	4426740	61655515	84708507	318	4041										
CHD7	55636	broad.mit.edu	37	chr8	61693742	61693742	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atcccagtaaaggttttggtAaagatgacttccctggtggg	12	7	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:61693742A>G	uc003xue.2	+	3	2326	c.1849A>G	c.(1849-1851)AAA>GAA	p.K617E		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	617	Lys-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGGTTTTGGTAAAGATGACTT	0.393													0	0	0	0.006214	0	9	7										G	61693742	A	G	61693742	3	3	16	1	0	0	0	0	1	0	0	0	3330	363	13	5	1855	5	CHD7	8	61693742	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	38227	61693742	84670280	319	4042										
ARMC1	55156	broad.mit.edu	37	chr8	66517678	66517678	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcagctttcaaatctgaacgGattcgcaccacacacctttg	6	13	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:66517678G>A	uc003xvl.2	-	5	796	c.561C>T	c.(559-561)ATC>ATT	p.I187I	ARMC1_uc011leo.1_Silent_p.I85I	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	187					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			AATCTGAACGGATTCGCACCA	0.333													0	0	0	0.00632	0	23	33										A	66517678	G	A	66517678	2	1	16	1	0	0	0	0	0	0	0	1	949	1164	41	1		1	ARMC1	8	66517678	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4823936	66517678	79846344	320	4043										
PREX2	80243	broad.mit.edu	37	chr8	69104737	69104737	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgggcgcctgccacatcatCatgtgcagcagcggtgtgca	13	13	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:69104737C>T	uc003xxv.1	+	37	4608	c.4581C>T	c.(4579-4581)ATC>ATT	p.I1527I		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1527					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GCCACATCATCATGTGCAGCA	0.522													0	0	0	0.008361	0	20	15										T	69104737	C	T	69104737	2	4	16	1	0	0	0	0	0	0	0	1	12477	816	29	1		1	PREX2	8	69104737	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2587059	69104737	77259285	321	4044										
TRPA1	8989	broad.mit.edu	37	chr8	72977734	72977734	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtggtgcacgcaatgatcacAgctgtgtttccattttctcc	9	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:72977734A>T	uc003xza.2	-	4	679	c.504T>A	c.(502-504)GCT>GCA	p.A168A		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	168	Cytoplasmic (Potential).|ANK 4.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CAATGATCACAGCTGTGTTTC	0.333													0	0	0	0.000602	0	5	32										T	72977734	A	T	72977734	2	4	16	1	0	0	0	0	0	0	0	1	16574	175	7	5		5	TRPA1	8	72977734	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3872997	72977734	73386288	322	4045										
RDH10	157506	broad.mit.edu	37	chr8	74233221	74233221	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcatgaatccctgagccatGaactaaaggctgctgaaaag	9	9	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:74233221G>A	uc003xzi.2	+	4	939	c.679G>A	c.(679-681)GAA>AAA	p.E227K	RDH10_uc003xzj.2_Missense_Mutation_p.E62K|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	227					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			CCTGAGCCATGAACTAAAGGC	0.443													0	0	0	0.013726	0	31	49										A	74233221	G	A	74233221	3	1	16	1	0	0	0	0	1	0	0	0	13189	1291	45	1	693	1	RDH10	8	74233221	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1255487	74233221	72130801	323	4046										
SLC7A13	157724	broad.mit.edu	37	chr8	87241991	87241991	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actccagttagggaaatgaaGctaagtatggacactttcag	10	7	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:87241991G>A	uc003ydq.1	-	1	614	c.516C>T	c.(514-516)AGC>AGT	p.S172S	SLC7A13_uc003ydr.1_Silent_p.S172S	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	172	Helical; Name=5; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						GGGAAATGAAGCTAAGTATGG	0.423													0	0	0	0.013726	0	30	35										A	87241991	G	A	87241991	2	1	16	1	0	0	0	0	0	0	0	1	14695	962	34	2		2	SLC7A13	8	87241991	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	13008770	87241991	59122031	324	4047										
WWP1	11059	broad.mit.edu	37	chr8	87442959	87442959	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcagaaaatgacccttatGgacctttgccaccaggctgg	10	12	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:87442959G>T	uc003ydt.2	+	12	1646	c.1366G>T	c.(1366-1368)GGA>TGA	p.G456*	WWP1_uc010mai.2_Nonsense_Mutation_p.G232*	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	456	WW 3.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TGACCCTTATGGACCTTTGCC	0.294													1	0	4.3838e-07	0.001855	4.59712e-07	11	50										T	87442959	G	T	87442959	4	4	16	1	0	0	0	0	0	1	0	0	17412	1349	47	4	1404	4	WWP1	8	87442959	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	200968	87442959	58921063	325	4048										
RBM12B	389677	broad.mit.edu	37	chr8	94747139	94747139	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggtcacctcgctcacgtgaCtgtgagcgagcttgcatttt	11	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:94747139C>G	uc003yfz.2	-	3	1693	c.1500G>C	c.(1498-1500)CAG>CAC	p.Q500H		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	500							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCTCACGTGACTGTGAGCGAG	0.408													0	0	0	0.012319	0	23	88										G	94747139	C	G	94747139	3	3	16	1	0	0	0	0	1	0	0	0	13114	564	20	4	1509	4	RBM12B	8	94747139	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7304180	94747139	51616883	326	4049										
RGS22	26166	broad.mit.edu	37	chr8	101083755	101083755	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccatcttacttgtgagaccaAtttggctaacctgcatttta	6	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:101083755A>G	uc003yjb.1	-	6	631	c.436T>C	c.(436-438)TTG>CTG	p.L146L	RGS22_uc003yja.1_Intron|RGS22_uc003yjc.1_Silent_p.L146L|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	146					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTGAGACCAATTTGGCTAAC	0.368													0	0	0	0.014323	0	19	24										G	101083755	A	G	101083755	2	3	16	1	0	0	0	0	0	0	0	1	13305	98	4	5		5	RGS22	8	101083755	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	6336616	101083755	45280267	327	4050										
CSMD3	114788	broad.mit.edu	37	chr8	113308174	113308174	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatacaactgtgtctctataTccataattttctccaatgac	3	10	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:113308174T>C	uc003ynu.2	-	54	8661	c.8502A>G	c.(8500-8502)GGA>GGG	p.G2834G	CSMD3_uc003yns.2_Silent_p.G2036G|CSMD3_uc003ynt.2_Silent_p.G2794G|CSMD3_uc011lhx.1_Silent_p.G2665G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2834	Extracellular (Potential).|Sushi 18.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTCTCTATATCCATAATTTT	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.010729	0	9	45										C	113308174	T	C	113308174	2	2	16	1	0	0	0	0	0	0	0	1	3946	1422	50	5		5	CSMD3	8	113308174	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	12224419	113308174	33055848	328	4051										
TRPS1	7227	broad.mit.edu	37	chr8	116616147	116616147	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acttgggtaataaaatcacaTttggtacatgagtgttcttt	8	5	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:116616147T>A	uc003ynz.2	-	3	2469	c.2010A>T	c.(2008-2010)AAA>AAT	p.K670N	TRPS1_uc011lhy.1_Missense_Mutation_p.K674N|TRPS1_uc003yny.2_Missense_Mutation_p.K683N|TRPS1_uc010mcy.2_Missense_Mutation_p.K670N	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	670	Mediates interaction with GLI3.|C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TAAAATCACATTTGGTACATG	0.443									Langer-Giedion_syndrome				0	0	0	0.008361	0	27	27										A	116616147	T	A	116616147	3	1	16	1	0	0	0	0	1	0	0	0	16590	1490	52	5	1851	5	TRPS1	8	116616147	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	3307973	116616147	29747875	329	4052										
FER1L6	654463	broad.mit.edu	37	chr8	124975540	124975540	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtcaaggtgacactgaagcActgcaggaggagccttctca	12	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:124975540A>C	uc003yqw.2	+	3	305	c.99A>C	c.(97-99)GCA>GCC	p.A33A		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	33	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACACTGAAGCACTGCAGGAGG	0.493													0	0	0	0.008871	0	19	99										C	124975540	A	C	124975540	2	2	16	1	0	0	0	0	0	0	0	1	5815	146	6	5		5	FER1L6	8	124975540	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	8359393	124975540	21388482	330	4053										
TRMT12	55039	broad.mit.edu	37	chr8	125463982	125463982	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtggaatccccatgctgtaGttgctctgagaaataacctt	9	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:125463982G>T	uc003yra.3	+	1	935	c.814G>T	c.(814-816)GTT>TTT	p.V272F		NM_017956	NP_060426	Q53H54	TYW2_HUMAN	homolog of yeast tRNA methyltransferase 12	272					tRNA processing		methyltransferase activity			upper_aerodigestive_tract(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CCATGCTGTAGTTGCTCTGAG	0.438													1	0	8.28177e-16	0.007413	8.92361e-16	19	130										T	125463982	G	T	125463982	3	4	16	1	0	0	0	0	1	0	0	0	16561	1029	36	4	816	4	TRMT12	8	125463982	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	488442	125463982	20900040	331	4054										
FAM84B	157638	broad.mit.edu	37	chr8	127569332	127569332	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgtaggtactcagcgccgcCgagcccggcgcgaagctctt	14	14	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:127569332C>T	uc003yrz.1	-	2	587	c.303G>A	c.(301-303)TCG>TCA	p.S101S		NM_174911	NP_777571	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	101						cytoplasm|plasma membrane	protein binding				0	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			TCAGCGCCGCCGAGCCCGGCG	0.657													0	0	0	0.000602	0	5	35										T	127569332	C	T	127569332	2	4	16	1	0	0	0	0	0	0	0	1	5642	639	23	2		2	FAM84B	8	127569332	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2105350	127569332	18794690	332	4055										
PHF20L1	51105	broad.mit.edu	37	chr8	133816268	133816268	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagatctgcctacatctagtGaaacatttggtacaaaatac	6	8	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:133816268G>A	uc003ytt.2	+	7	1037	c.712G>A	c.(712-714)GAA>AAA	p.E238K	PHF20L1_uc003ytr.2_Missense_Mutation_p.E212K|PHF20L1_uc010mdv.2_Missense_Mutation_p.E212K|PHF20L1_uc003yts.2_Missense_Mutation_p.E238K|PHF20L1_uc011lja.1_Missense_Mutation_p.E212K|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytv.2_Missense_Mutation_p.E77K	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	238							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TACATCTAGTGAAACATTTGG	0.368													0	0	0	0.009096	0	4	23										A	133816268	G	A	133816268	3	1	16	1	0	0	0	0	1	0	0	0	11832	1291	45	1	734	1	PHF20L1	8	133816268	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6246936	133816268	12547754	333	4056										
DENND3	22898	broad.mit.edu	37	chr8	142175310	142175310	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agacacctacatgttccattCttttcttaaagcccggctca	5	13	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:142175310C>G	uc003yvy.2	+	11	1513	c.1235C>G	c.(1234-1236)TCT>TGT	p.S412C	DENND3_uc010mep.2_Missense_Mutation_p.S373C|DENND3_uc003yvz.1_Missense_Mutation_p.S96C	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	412	dDENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			ATGTTCCATTCTTTTCTTAAA	0.557													0	0	0	0.01441	0	51	71										G	142175310	C	G	142175310	3	3	16	1	0	0	0	0	1	0	0	0	4432	913	32	1	1273	1	DENND3	8	142175310	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	8359042	142175310	4188712	334	4057										
GSDMD	79792	broad.mit.edu	37	chr8	144641548	144641548	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tagtccggagagtggtccagGagctggaccatggtggggag	19	7	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:144641548G>A	uc010mfe.2	+	5	746	c.43G>A	c.(43-45)GAG>AAG	p.E15K	uc003yye.2_5'Flank|GSDMD_uc003yyf.2_Missense_Mutation_p.E63K|GSDMD_uc003yyi.2_Missense_Mutation_p.E15K|GSDMD_uc003yyg.2_Missense_Mutation_p.E15K|GSDMD_uc003yyh.2_Missense_Mutation_p.E15K	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	15											0						AGTGGTCCAGGAGCTGGACCA	0.632													0	0	0	0.012319	0	22	36										A	144641548	G	A	144641548	3	1	16	1	0	0	0	0	1	0	0	0	6819	1175	41	1	45	1	GSDMD	8	144641548	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2466238	144641548	1722474	335	4058										
FBXL6	26233	broad.mit.edu	37	chr8	145580113	145580113	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgccaggcagagctcctctaGgctagggaagcctggtccgg	15	13	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145580113G>A	uc003zcb.2	-	7	1097	c.1072C>T	c.(1072-1074)CTA>TTA	p.L358L	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Silent_p.L85L|FBXL6_uc003zca.2_Silent_p.L352L|FBXL6_uc010mfx.2_Silent_p.L119L|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	358	LRR 6.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			AGCTCCTCTAGGCTAGGGAAG	0.642													0	0	0	0.00245	0	14	66										A	145580113	G	A	145580113	2	1	16	1	0	0	0	0	0	0	0	1	5723	991	35	2		2	FBXL6	8	145580113	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	938565	145580113	783909	336	4059										
GPR172A	79581	broad.mit.edu	37	chr8	145583820	145583820	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctgttgccgccaccaccatCtgtacccacaggggagttag	11	14	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145583820C>T	uc003zcc.1	+	3	825	c.668C>T	c.(667-669)TCT>TTT	p.S223F	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.S223F|GPR172A_uc003zce.1_Missense_Mutation_p.S223F|GPR172A_uc010mfy.1_Missense_Mutation_p.S223F|GPR172A_uc003zcf.1_Missense_Mutation_p.S223F|GPR172A_uc011llc.1_Missense_Mutation_p.S135F	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	223						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCACCACCATCTGTACCCACA	0.612													0	0	0	0.00874	0	40	39										T	145583820	C	T	145583820	3	4	16	1	0	0	0	0	1	0	0	0	6669	913	32	1	674	1	GPR172A	8	145583820	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3707	145583820	780202	337	4060										
NFKBIL2	4796	broad.mit.edu	37	chr8	145659460	145659460	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggagggccaggctgggcatGgtgcccagggcagccaccag	18	12	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145659460G>A	uc011llg.1	-	21	3303	c.3288C>T	c.(3286-3288)ACC>ACT	p.T1096T	uc011llh.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1096					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCTGGGCATGGTGCCCAGGG	0.687													0	0	0	0.013726	0	30	21										A	145659460	G	A	145659460	2	1	16	1	0	0	0	0	0	0	0	1	10382	1335	47	2		2	NFKBIL2	8	145659460	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	75640	145659460	704562	338	4061										
KIFC2	90990	broad.mit.edu	37	chr8	145698738	145698738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcccgacaacggctcgggctCggctctcgcgcccgcagagg	14	17	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145698738C>T	uc003zcz.2	+	17	2487	c.2422C>T	c.(2422-2424)CGG>TGG	p.R808W	KIFC2_uc003zda.2_Missense_Mutation_p.R196W	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	808	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCTCGGGCTCGGCTCTCGCG	0.701													0	0	0	0.000602	0	5	12										T	145698738	C	T	145698738	3	4	16	1	0	0	0	0	1	0	0	0	8313	875	31	1	2488	1	KIFC2	8	145698738	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	39278	145698738	665284	339	4062										
DMRT2	10655	broad.mit.edu	37	chr9	1057223	1057223	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaccactgtcattttctgttGagtctattcttaagaggcct	7	9	4	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:1057223G>C	uc003zha.2	+	4	1836	c.1636G>C	c.(1636-1638)GAG>CAG	p.E546Q	DMRT2_uc003zgx.3_Missense_Mutation_p.E313Q|DMRT2_uc010mgz.2_Missense_Mutation_p.E313Q|DMRT2_uc003zgy.3_Missense_Mutation_p.E390Q|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.E546Q	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	546					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		ATTTTCTGTTGAGTCTATTCT	0.393													0	0	0	0.00333	0	22	19										C	1057223	G	C	1057223	3	2	16	1	0	0	0	0	1	0	0	0	4586	1291	45	1	1703	1	DMRT2	9	1057223	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		1057223	140156208	340	4063										
GLIS3	169792	broad.mit.edu	37	chr9	3828335	3828335	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccacggtgctgatctgcaaGaaggtagcatcttcagcccc	10	13	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:3828335G>A	uc003zhw.1	-	10	2459	c.2265C>T	c.(2263-2265)TTC>TTT	p.F755F	GLIS3_uc003zhx.1_Silent_p.F910F|GLIS3_uc010mhf.1_Silent_p.F304F|GLIS3_uc003zhv.1_RNA	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	755					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TGATCTGCAAGAAGGTAGCAT	0.542													0	0	0	0.006214	0	10	10										A	3828335	G	A	3828335	2	1	16	1	0	0	0	0	0	0	0	1	6447	933	33	1		1	GLIS3	9	3828335	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2771112	3828335	137385096	341	4064										
RLN2	6019	broad.mit.edu	37	chr9	5304391	5304391	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgccactggtctaggtgtctGaggagcatcttcctggctca	12	11	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:5304391G>A	uc003zja.1	-	1	190	c.190C>T	c.(190-192)CAG>TAG	p.Q64*	RLN2_uc003ziz.1_Nonsense_Mutation_p.Q64*	NM_134441	NP_604390	P04090	REL2_HUMAN	relaxin 2 isoform 1 preproprotein	64					female pregnancy	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		CTAGGTGTCTGAGGAGCATCT	0.597													0	0	0	0.001168	0	6	7										A	5304391	G	A	5304391	4	1	16	1	0	0	0	0	0	1	0	0	13392	1299	45	1	480	1	RLN2	9	5304391	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1476056	5304391	135909040	342	4065										
PSIP1	11168	broad.mit.edu	37	chr9	15469043	15469043	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttcatccaaggcctcaatgCatctgttcacatccttcatg	6	13	5	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:15469043C>A	uc003zlv.3	-	13	1448	c.1118G>T	c.(1117-1119)TGC>TTC	p.C373F	PSIP1_uc003zlw.3_Missense_Mutation_p.C373F	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	373	Potential.				initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		GGCCTCAATGCATCTGTTCAC	0.343													1	0	1.33834e-09	0.007413	1.419e-09	18	11										A	15469043	C	A	15469043	3	1	16	1	0	0	0	0	1	0	0	0	12663	710	25	4	490	4	PSIP1	9	15469043	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	10164652	15469043	125744388	343	4066										
ARID3C	138715	broad.mit.edu	37	chr9	34623620	34623620	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtaagcctggcgacggccctCgcgccgattgctgtctatgg	14	13	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:34623620C>T	uc011lon.1	-	4	667	c.667G>A	c.(667-669)GAG>AAG	p.E223K		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CGACGGCCCTCGCGCCGATTG	0.701													0	0	0	0.006214	0	10	8										T	34623620	C	T	34623620	3	4	16	1	0	0	0	0	1	0	0	0	918	893	31	1	586	1	ARID3C	9	34623620	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	19154577	34623620	106589811	344	4067										
C9orf79	286234	broad.mit.edu	37	chr9	90501167	90501167	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctctctcctcaaaaagtctCaggctgttctgagccagccc	7	16	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:90501167C>T	uc004app.3	+	4	1800	c.1765C>T	c.(1765-1767)CAG>TAG	p.Q589*	C9orf79_uc004apo.1_Nonsense_Mutation_p.Q401*	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	589						integral to membrane				ovary(3)	3						CAAAAAGTCTCAGGCTGTTCT	0.587													0	0	0	0.01441	0	54	62										T	90501167	C	T	90501167	4	4	16	1	0	0	0	0	0	1	0	0	2497	827	29	1	1779	1	C9orf79	9	90501167	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	55877547	90501167	50712264	345	4068										
C9orf3	84909	broad.mit.edu	37	chr9	97844946	97844946	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggtgcttcgagcggaccaaGgagcagatggataggtcctc	15	9	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:97844946G>A	uc004ava.2	+	15	2544	c.2409G>A	c.(2407-2409)AAG>AAA	p.K803K	C9orf3_uc004auy.2_Silent_p.K704K|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Silent_p.K165K|C9orf3_uc011luk.1_Silent_p.K144K|C9orf3_uc004avd.2_Silent_p.K165K|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	803					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGCGGACCAAGGAGCAGATGG	0.547													0	0	0	0.013726	0	32	26										A	97844946	G	A	97844946	2	1	16	1	0	0	0	0	0	0	0	1	2477	991	35	2		2	C9orf3	9	97844946	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7343779	97844946	43368485	346	4069										
TSTD2	158427	broad.mit.edu	37	chr9	100388271	100388271	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctttggttttgacaaaaagGgcaaaggcctgcaattagat	10	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:100388271G>T	uc004axn.2	-	3	662	c.174C>A	c.(172-174)GCC>GCA	p.A58A	TSTD2_uc004axo.2_5'UTR|TSTD2_uc004axp.1_5'UTR	NM_139246	NP_640339	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like	58										ovary(2)	2						TGACAAAAAGGGCAAAGGCCT	0.353													1	0	5.9392e-07	0.001168	6.22064e-07	6	6										T	100388271	G	T	100388271	2	4	16	1	0	0	0	0	0	0	0	1	16672	1219	43	4		4	TSTD2	9	100388271	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2543325	100388271	40825160	347	4070										
SVEP1	79987	broad.mit.edu	37	chr9	113205828	113205828	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attttgttaaaacataccagGtatgggcaaaccaacagaga	8	7	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:113205828G>T	uc010mtz.2	-	27	4973	c.4636C>A	c.(4636-4638)CCT>ACT	p.P1546T	SVEP1_uc010mua.1_Missense_Mutation_p.P1546T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1546	Pentaxin.			P -> PGMF (in Ref. 1; CAF04067).	cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AACATACCAGGTATGGGCAAA	0.418													1	0	0.000157383	0.00308	0.000163846	7	6										T	113205828	G	T	113205828	3	4	16	1	0	0	0	0	1	0	0	0	15417	1261	44	4	6167	4	SVEP1	9	113205828	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	12817557	113205828	28007603	348	4071										
ZFP37	7539	broad.mit.edu	37	chr9	115805712	115805712	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcacctgtgtgagatctcaCatgttgaataaggtttgagc	10	8	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:115805712C>A	uc004bgm.1	-	4	1214	c.1186G>T	c.(1186-1188)GTG>TTG	p.V396L	ZFP37_uc011lwz.1_Missense_Mutation_p.V411L|ZFP37_uc011lxa.1_Missense_Mutation_p.V397L	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	396	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGAGATCTCACATGTTGAATA	0.413													1	0	5.7616e-29	0.01441	6.25504e-29	47	34										A	115805712	C	A	115805712	3	1	16	1	0	0	0	0	1	0	0	0	17645	478	17	4	710	4	ZFP37	9	115805712	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2599884	115805712	25407719	349	4072										
PRPF4	9128	broad.mit.edu	37	chr9	116050456	116050456	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgtttggttcctttccagtGatgaaccagtggcagatatt	10	7	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:116050456G>A	uc004bgx.2	+	10	987	c.937G>A	c.(937-939)GAT>AAT	p.D313N	PRPF4_uc004bgy.2_Missense_Mutation_p.D312N	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	313	WD 2.					Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						CCTTTCCAGTGATGAACCAGT	0.458													0	0	0	0.003163	0	13	18										A	116050456	G	A	116050456	3	1	16	1	0	0	0	0	1	0	0	0	12570	1304	45	1	975	1	PRPF4	9	116050456	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	244744	116050456	25162975	350	4073										
OR1B1	347169	broad.mit.edu	37	chr9	125391656	125391656	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggtgagtgcagtctggagtcCcaggagatgagcagcaccag	16	9	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:125391656C>T	uc011lyz.1	-	1	159	c.159G>A	c.(157-159)TGG>TGA	p.W53*		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCTGGAGTCCCAGGAGATGA	0.522													0	0	0	0.006122	0	17	12										T	125391656	C	T	125391656	4	4	16	1	0	0	0	0	0	1	0	0	10951	624	22	2	800	2	OR1B1	9	125391656	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	9341200	125391656	15821775	351	4074										
GARNL3	84253	broad.mit.edu	37	chr9	130027210	130027210	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agatcgctatgtataatactGatgaagcatttttgttccag	8	6	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:130027210G>A	uc011mae.1	+	1	455	c.54G>A	c.(52-54)CTG>CTA	p.L18L	GARNL3_uc011mad.1_Intron	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	18					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTATAATACTGATGAAGCATT	0.453													0	0	0	0.00278	0	23	29										A	130027210	G	A	130027210	2	1	16	1	0	0	0	0	0	0	0	1	6241	1277	45	1		1	GARNL3	9	130027210	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4635554	130027210	11186221	352	4075										
TPRN	286262	broad.mit.edu	37	chr9	140093630	140093630	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actgaagtgctggtcctgcaGagtccctggcttcctcttgg	12	12	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:140093630G>A	uc004clt.2	-	1	1351	c.1351C>T	c.(1351-1353)CTG>TTG	p.L451L	TPRN_uc004clu.2_Silent_p.L451L	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	512					sensory perception of sound	stereocilium					0						TGGTCCTGCAGAGTCCCTGGC	0.672													0	0	0	0.01441	0	48	37										A	140093630	G	A	140093630	2	1	16	1	0	0	0	0	0	0	0	1	16418	933	33	1		1	TPRN	9	140093630	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	10066420	140093630	1119801	353	4076										
FAM166A	401565	broad.mit.edu	37	chr9	140139108	140139108	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcctacctggctcttgtcgaAttcgtccatggcttgcatga	9	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:140139108A>G	uc004cmi.1	-	5	788	c.733T>C	c.(733-735)TTC>CTC	p.F245L		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	245										ovary(1)	1						CTCTTGTCGAATTCGTCCATG	0.577													0	0	0	0.005443	0	24	18										G	140139108	A	G	140139108	3	3	16	1	0	0	0	0	1	0	0	0	5481	101	4	5	232	5	FAM166A	9	140139108	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	45478	140139108	1074323	354	4077										
DIP2C	22982	broad.mit.edu	37	chr10	486827	486827	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttacctggaggggtgtaggcGtccatcgaggtctgcacgac	15	10	1	0	rs139321678	byFrequency	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:486827G>A	uc001ifp.2	-	4	468	c.378C>T	c.(376-378)GAC>GAT	p.D126D	DIP2C_uc009xhk.1_Missense_Mutation_p.T128M	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	126						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGTGTAGGCGTCCATCGAGG	0.607													0	0	0	0.006122	0	15	45										A	486827	G	A	486827	2	1	16	1	0	0	0	0	0	0	0	1	4529	1136	40	2		2	DIP2C	10	486827	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		486827	135047920	355	4078										
IDI2	91734	broad.mit.edu	37	chr10	1066834	1066834	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tactacaggagtcggtaaaaTaccctggaaaaaatgcatgt	9	7	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:1066834T>C	uc001ifv.1	-	4	304	c.239A>G	c.(238-240)TAT>TGT	p.Y80C	C10orf110_uc010qaf.1_5'Flank|C10orf110_uc001ifx.3_5'Flank|C10orf110_uc001ifw.3_5'Flank|C10orf110_uc001ify.3_5'Flank	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	80	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		GTCGGTAAAATACCCTGGAAA	0.443													0	0	0	0.008871	0	16	27										C	1066834	T	C	1066834	3	2	16	1	0	0	0	0	1	0	0	0	7500	1406	49	5	452	5	IDI2	10	1066834	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	580007	1066834	134467913	356	4079										
FRMD4A	55691	broad.mit.edu	37	chr10	13782239	13782239	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	taggttgggagagactccacGatgctcatgtagctggaatg	14	7	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:13782239G>A	uc001ims.2	-	11	979	c.627C>T	c.(625-627)ATC>ATT	p.I209I	FRMD4A_uc009xjf.1_Silent_p.I209I|FRMD4A_uc001imt.1_Silent_p.I242I|FRMD4A_uc001imu.1_Silent_p.I225I	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	209	FERM.					cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GAGACTCCACGATGCTCATGT	0.423													0	0	0	0.00499	0	17	56										A	13782239	G	A	13782239	2	1	16	1	0	0	0	0	0	0	0	1	6051	1048	37	1		1	FRMD4A	10	13782239	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	12715405	13782239	121752508	357	4080										
PLXDC2	84898	broad.mit.edu	37	chr10	20453444	20453444	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcaaccaatcatccagtgaaAgtcggactgtccgatgcatt	8	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:20453444A>T	uc001iqg.1	+	7	1468	c.831A>T	c.(829-831)AAA>AAT	p.K277N	PLXDC2_uc001iqh.1_Missense_Mutation_p.K228N|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	277	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						ATCCAGTGAAAGTCGGACTGT	0.443													0	0	0	0.009096	0	4	43										T	20453444	A	T	20453444	3	4	16	1	0	0	0	0	1	0	0	0	12118	69	3	5	857	5	PLXDC2	10	20453444	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	6671205	20453444	115081303	358	4081										
ABI1	10006	broad.mit.edu	37	chr10	27149698	27149698	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtatgtagttgttttcacagTagtctgccacccgagtcagg	11	9	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:27149698T>C	uc001isx.2	-	1	262	c.95A>G	c.(94-96)TAC>TGC	p.Y32C	ABI1_uc001ite.2_Missense_Mutation_p.Y32C|ABI1_uc010qdh.1_Missense_Mutation_p.Y32C|ABI1_uc010qdi.1_Missense_Mutation_p.Y32C|ABI1_uc001isy.2_Missense_Mutation_p.Y32C|ABI1_uc001ita.2_Missense_Mutation_p.Y32C|ABI1_uc001isz.2_Missense_Mutation_p.Y32C|ABI1_uc001itb.2_Missense_Mutation_p.Y32C|ABI1_uc001itc.2_Missense_Mutation_p.Y32C|ABI1_uc010qdj.1_Missense_Mutation_p.Y32C|ABI1_uc001itd.2_Missense_Mutation_p.Y32C|ABI1_uc010qdk.1_Missense_Mutation_p.Y32C	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	32	Required for binding to WASF1 (By similarity).				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						GTTTTCACAGTAGTCTGCCAC	0.627													0	0	0	0.003954	0	24	62										C	27149698	T	C	27149698	3	2	16	1	0	0	0	0	1	0	0	0	88	1638	57	5	1534	5	ABI1	10	27149698	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	6696254	27149698	108385049	359	4082										
RAB18	22931	broad.mit.edu	37	chr10	27793340	27793340	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	accctgaagatcctcatcatCggcgagagtggggtgggcaa	14	10	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:27793340C>T	uc001itv.2	+	1	92	c.42C>T	c.(40-42)ATC>ATT	p.I14I	RAB18_uc001itw.2_Silent_p.I14I|RAB18_uc010qdq.1_Silent_p.I14I|RAB18_uc010qdr.1_Silent_p.I14I	NM_021252	NP_067075	Q9NP72	RAB18_HUMAN	RAB18, member RAS oncogene family	14					endocytosis|protein transport|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|GTPase activity|transcription factor binding				0						TCCTCATCATCGGCGAGAGTG	0.682													0	0	0	0.00308	0	5	10										T	27793340	C	T	27793340	2	4	16	1	0	0	0	0	0	0	0	1	12903	874	31	1		1	RAB18	10	27793340	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	643642	27793340	107741407	360	4083										
CCNY	219771	broad.mit.edu	37	chr10	35842099	35842100	+	Frame_Shift_Del	DEL	CA	CA	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgccagatcctgaaagacatCacggtggaggacatgtgagt							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:35842099_35842100delCA	uc001iyw.3	+	8	912_913	c.732_733delCA	c.(730-735)ATCACGfs	p.I244fs	CCNY_uc001iyu.3_Frame_Shift_Del_p.I190fs|CCNY_uc001iyv.3_Frame_Shift_Del_p.I190fs|CCNY_uc001iyx.3_Frame_Shift_Del_p.I190fs|CCNY_uc009xmb.2_Frame_Shift_Del_p.I219fs|CCNY_uc010qet.1_Frame_Shift_Del_p.I111fs	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1	244_245	Cyclin N-terminal.				cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						TGAAAGACATCACGGTGGAGGA	0.515																		23	58	---	---								-	35842100	CA	-	35842099	7	5	16	1	0	1	0	1	0	0	0	0	2936	816	29	0	762	0	CCNY	10	35842099	Frame_Shift_Del	DEL	CA	TCGA-BT-A2LB-01A-11D-A18F-08	8048759	35842099	99692648	361	4084										
RBP3	5949	broad.mit.edu	37	chr10	48389779	48389779	+	Missense_Mutation	SNP	C	C	T													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attgagcttggtgaccagatCttcctcggagaccaccgtgg							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:48389779C>T	uc001jez.2	-	1	1213	c.1099G>A	c.(1099-1101)GAT>AAT	p.D367N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	367	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GTGACCAGATCTTCCTCGGAG	0.632													0	0	0	0.001855	0	14	33										T	48389779	C	T	48389779	3	4	16	1	0	0	0	0	1	0	0	0	13157	913	32	1	2660	1	RBP3	10	48389779	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	12547680	48389779	87144968	362	4085	21	2								
RBP3	5949	broad.mit.edu	37	chr10	48389782	48389782	+	Missense_Mutation	SNP	C	C	T													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagcttggtgaccagatcttCctcggagaccaccgtggaga							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:48389782C>T	uc001jez.2	-	1	1210	c.1096G>A	c.(1096-1098)GAA>AAA	p.E366K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	366	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	ACCAGATCTTCCTCGGAGACC	0.627													0	0	0	0.00245	0	15	31										T	48389782	C	T	48389782	3	4	16	1	0	0	0	0	1	0	0	0	13157	864	30	1	2663	1	RBP3	10	48389782	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3	48389782	87144965	363	4086	21	2								
RHOBTB1	9886	broad.mit.edu	37	chr10	62631954	62631954	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagtctcacctgcagattttGatttgatttccttacggaac	7	10	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:62631954G>A	uc001jli.2	-	11	2348	c.1910C>T	c.(1909-1911)TCA>TTA	p.S637L	RHOBTB1_uc001jlh.2_Missense_Mutation_p.S637L|RHOBTB1_uc001jlj.2_Missense_Mutation_p.S637L|RHOBTB1_uc001jlk.2_Missense_Mutation_p.S637L|RHOBTB1_uc009xpe.1_Missense_Mutation_p.S575L|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.S387L	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	637					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					TGCAGATTTTGATTTGATTTC	0.493													0	0	0	0.014323	0	23	72										A	62631954	G	A	62631954	3	1	16	1	0	0	0	0	1	0	0	0	13333	1294	45	1	188	1	RHOBTB1	10	62631954	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	14242172	62631954	72902793	364	4087										
VPS26A	9559	broad.mit.edu	37	chr10	70930917	70930917	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcatttgtttactaggagatAattttatggagaaaagctcc	9	5	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:70930917A>G	uc001jpb.2	+	9	1002	c.876A>G	c.(874-876)ATA>ATG	p.I292M	VPS26A_uc001jpc.2_Missense_Mutation_p.N245D|VPS26A_uc009xqa.2_Missense_Mutation_p.I285M|VPS26A_uc001jpd.2_Missense_Mutation_p.I181M	NM_004896	NP_004887	O75436	VP26A_HUMAN	vacuolar protein sorting 26 A isoform 1	292					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity				0						ACTAGGAGATAATTTTATGGA	0.338													0	0	0	0.014323	0	23	64										G	70930917	A	G	70930917	3	3	16	1	0	0	0	0	1	0	0	0	17194	362	13	5	910	5	VPS26A	10	70930917	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	8298963	70930917	64603830	365	4088										
SUPV3L1	6832	broad.mit.edu	37	chr10	70940254	70940254	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgttcgtgcccctgactgtGaaacctcagggccccagcgc	11	15	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:70940254G>A	uc001jpe.1	+	1	262	c.207G>A	c.(205-207)GTG>GTA	p.V69V	SUPV3L1_uc010qjd.1_5'UTR	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	69					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						CCCTGACTGTGAAACCTCAGG	0.647													0	0	0	0.00278	0	21	95										A	70940254	G	A	70940254	2	1	16	1	0	0	0	0	0	0	0	1	15399	1277	45	1		1	SUPV3L1	10	70940254	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	9337	70940254	64594493	366	4089										
SUPV3L1	6832	broad.mit.edu	37	chr10	70967593	70967593	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagcccctgacctttgcatgGttacgccgatacatcaaatg	9	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:70967593G>T	uc001jpe.1	+	14	1876	c.1821G>T	c.(1819-1821)TGG>TGT	p.W607C	SUPV3L1_uc010qjd.1_Missense_Mutation_p.W476C	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	607					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						CCTTTGCATGGTTACGCCGAT	0.443													1	0	0.00829132	0.008291	0.00853897	9	40										T	70967593	G	T	70967593	3	4	16	1	0	0	0	0	1	0	0	0	15399	1270	44	4	1875	4	SUPV3L1	10	70967593	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	27339	70967593	64567154	367	4090										
P4HA1	5033	broad.mit.edu	37	chr10	74813169	74813169	+	Frame_Shift_Del	DEL	C	C	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caggtctccctgctgatataCcgcatagctcaaataatcta							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:74813169delC	uc010qka.1	-	7	977	c.643delG	c.(643-645)GTAfs	p.V215fs	P4HA1_uc001jtg.2_Frame_Shift_Del_p.V215fs|P4HA1_uc001jth.2_Frame_Shift_Del_p.V215fs|P4HA1_uc010qkb.1_Frame_Shift_Del_p.V215fs|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	215	TPR.					endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGCTGATATACCGCATAGCTC	0.413																		14	68	---	---								-	74813169	C	-	74813169	7	5	16	1	0	1	0	1	0	0	0	0	11356	507	18	0	1076	0	P4HA1	10	74813169	Frame_Shift_Del	DEL	C	TCGA-BT-A2LB-01A-11D-A18F-08	3845576	74813169	60721578	368	4091										
FUT11	170384	broad.mit.edu	37	chr10	75533107	75533107	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccatctgtaacgactacatgAcagaaaaactgtggcgtccc	8	12	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:75533107A>T	uc001jva.2	+	2	911	c.868A>T	c.(868-870)ACA>TCA	p.T290S	FUT11_uc001juy.1_Nonstop_Mutation_p.*288C|FUT11_uc001juz.1_Missense_Mutation_p.T290S	NM_173540	NP_775811	Q495W5	FUT11_HUMAN	fucosyltransferase 11 (alpha (1,3)	290	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	Prostate(51;0.0112)					CGACTACATGACAGAAAAACT	0.567													0	0	0	0.004656	0	25	48										T	75533107	A	T	75533107	3	4	16	1	0	0	0	0	1	0	0	0	6103	275	10	5	874	5	FUT11	10	75533107	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	719938	75533107	60001640	369	4092										
KIAA0913	23053	broad.mit.edu	37	chr10	75556602	75556602	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctgagttctttctactcatCtagccgcccaaccacagcca	6	16	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:75556602C>T	uc009xrl.2	+	16	3121	c.3089C>T	c.(3088-3090)TCT>TTT	p.S1030F	KIAA0913_uc001jve.2_Missense_Mutation_p.S1035F|KIAA0913_uc001jvf.2_Missense_Mutation_p.S1030F|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.S465F|KIAA0913_uc010qkr.1_Missense_Mutation_p.S453F|KIAA0913_uc001jvj.2_Missense_Mutation_p.S453F|KIAA0913_uc009xrn.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1030							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					TTCTACTCATCTAGCCGCCCA	0.577													0	0	0	0.00245	0	14	72										T	75556602	C	T	75556602	3	4	16	1	0	0	0	0	1	0	0	0	8200	913	32	1	3166	1	KIAA0913	10	75556602	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	23495	75556602	59978145	370	4093										
TNKS2	80351	broad.mit.edu	37	chr10	93605573	93605573	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caatgccacggacaaatgggCtttcacacctttgcacgaag	9	12	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:93605573C>G	uc001khp.2	+	18	2531	c.2234C>G	c.(2233-2235)GCT>GGT	p.A745G		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	745	ANK 15.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				GACAAATGGGCTTTCACACCT	0.433													0	0	0	0.001168	0	6	46										G	93605573	C	G	93605573	3	3	16	1	0	0	0	0	1	0	0	0	16318	797	28	4	2304	4	TNKS2	10	93605573	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	18048971	93605573	41929174	371	4094										
BTAF1	9044	broad.mit.edu	37	chr10	93768614	93768614	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaactggttagcatttcttaAtaagtataaacttcatggaa	7	5	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:93768614A>G	uc001khr.2	+	27	3940	c.3842A>G	c.(3841-3843)AAT>AGT	p.N1281S		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1281	Helicase ATP-binding.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				GCATTTCTTAATAAGTATAAA	0.294													0	0	0	0.001855	0	9	42										G	93768614	A	G	93768614	3	3	16	1	0	0	0	0	1	0	0	0	1536	101	4	5	3948	5	BTAF1	10	93768614	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	163041	93768614	41766133	372	4095										
EXOC6	54536	broad.mit.edu	37	chr10	94757304	94757304	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttaatgcagatgctactggAcagtgagttaaaacaaataa	8	6	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:94757304A>G	uc001kig.2	+	19	2093	c.2027A>G	c.(2026-2028)GAC>GGC	p.D676G	EXOC6_uc010qnr.1_Missense_Mutation_p.D692G|EXOC6_uc001kie.2_Missense_Mutation_p.D671G|EXOC6_uc009xub.2_Missense_Mutation_p.D675G|EXOC6_uc009xuc.2_Missense_Mutation_p.D573G|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Missense_Mutation_p.D250G	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	676					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				ATGCTACTGGACAGTGAGTTA	0.353													0	0	0	0.001984	0	7	41										G	94757304	A	G	94757304	3	3	16	1	0	0	0	0	1	0	0	0	5308	275	10	5	2191	5	EXOC6	10	94757304	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	988690	94757304	40777443	373	4096										
MYOF	26509	broad.mit.edu	37	chr10	95113570	95113570	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agattttttttcctttacctGaaaagctatccttatctaaa	3	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:95113570G>A	uc001kin.2	-	32	3602	c.3479C>T	c.(3478-3480)TCA>TTA	p.S1160L	MYOF_uc001kio.2_Missense_Mutation_p.S1147L|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1160	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TCCTTTACCTGAAAAGCTATC	0.353													0	0	0	0.005443	0	24	77										A	95113570	G	A	95113570	3	1	16	1	0	0	0	0	1	0	0	0	10089	1294	45	1	2798	1	MYOF	10	95113570	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	356266	95113570	40421177	374	4097										
DNTT	1791	broad.mit.edu	37	chr10	98079103	98079103	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaaagatctcccagtatgcgTgtcagagaagaaccacttta	8	9	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:98079103T>C	uc001kmf.2	+	3	633	c.463T>C	c.(463-465)TGT>CGT	p.C155R	DNTT_uc001kmg.2_Missense_Mutation_p.C155R	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	155	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		CCAGTATGCGTGTCAGAGAAG	0.458													0	0	0	0.003271	0	31	120										C	98079103	T	C	98079103	3	2	16	1	0	0	0	0	1	0	0	0	4680	1696	59	5	473	5	DNTT	10	98079103	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	2965533	98079103	37455644	375	4098										
SEC31B	25956	broad.mit.edu	37	chr10	102256971	102256971	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccacactccctgagcacacaTaacagagtctggcttcggag	9	14	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:102256971T>C	uc001krc.1	-	17	2159	c.2057A>G	c.(2056-2058)TAT>TGT	p.Y686C	SEC31B_uc010qpo.1_Missense_Mutation_p.Y685C|SEC31B_uc001krd.1_Missense_Mutation_p.Y223C|SEC31B_uc001krf.1_Missense_Mutation_p.Y223C|SEC31B_uc001kre.1_Missense_Mutation_p.Y223C|SEC31B_uc001krg.1_Missense_Mutation_p.Y255C	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	686	WD 7.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TGAGCACACATAACAGAGTCT	0.567													0	0	0	0.007413	0	14	53										C	102256971	T	C	102256971	3	2	16	1	0	0	0	0	1	0	0	0	13999	1406	49	5	1522	5	SEC31B	10	102256971	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	4177868	102256971	33277776	376	4099										
LDB1	8861	broad.mit.edu	37	chr10	103868023	103868023	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagccgggtgatgagcctctCgtcctcgtccccgaactccc	10	18	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:103868023C>T	uc009xwz.2	-	11	1406	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	LDB1_uc001kuk.3_Missense_Mutation_p.E319K	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	355	LIM-binding domain (LID) (By similarity).				histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		ATGAGCCTCTCGTCCTCGTCC	0.622													0	0	0	0.001855	0	12	45										T	103868023	C	T	103868023	3	4	16	1	0	0	0	0	1	0	0	0	8695	893	31	1	176	1	LDB1	10	103868023	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1611052	103868023	31666724	377	4100										
COL17A1	1308	broad.mit.edu	37	chr10	105802183	105802183	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagggtgtgacataccttgaTgtcctgggagaccagctggg	15	9	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:105802183T>C	uc001kxr.2	-	36	2715	c.2546A>G	c.(2545-2547)CAT>CGT	p.H849R		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	849	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CATACCTTGATGTCCTGGGAG	0.537													0	0	0	0.006214	0	8	40										C	105802183	T	C	105802183	3	2	16	1	0	0	0	0	1	0	0	0	3674	1464	51	5	2031	5	COL17A1	10	105802183	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1934160	105802183	29732564	378	4101										
PDCD4	27250	broad.mit.edu	37	chr10	112641080	112641080	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgaaataaatggaaattggAtttcagcatcctccattaac	6	7	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:112641080A>G	uc001kzh.2	+	3	376	c.133A>G	c.(133-135)ATT>GTT	p.I45V	PDCD4_uc001kzg.2_Missense_Mutation_p.I34V|PDCD4_uc010qre.1_Missense_Mutation_p.I31V	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	45					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGGAAATTGGATTTCAGCATC	0.413													0	0	0	0.00278	0	23	88										G	112641080	A	G	112641080	3	3	16	1	0	0	0	0	1	0	0	0	11621	333	12	5	153	5	PDCD4	10	112641080	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	6838897	112641080	22893667	379	4102										
SHOC2	8036	broad.mit.edu	37	chr10	112771502	112771502	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cactcagtcaccttccacctCagattgttgctggggggcct	10	14	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:112771502C>G	uc001kzl.3	+	9	2024	c.1675C>G	c.(1675-1677)CAG>GAG	p.Q559E	SHOC2_uc009xxx.2_Missense_Mutation_p.Q559E|SHOC2_uc010qrg.1_Missense_Mutation_p.Q198E|SHOC2_uc001kzn.2_Missense_Mutation_p.Q513E	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	559	LRR 20.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		CCTTCCACCTCAGATTGTTGC	0.488													0	0	0	0.005524	0	36	58										G	112771502	C	G	112771502	3	3	16	1	0	0	0	0	1	0	0	0	14287	827	29	1	1705	1	SHOC2	10	112771502	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	130422	112771502	22763245	380	4103										
RAB11FIP2	22841	broad.mit.edu	37	chr10	119799820	119799820	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttggatttcatctgtatttCaccacttgaaaattcactat	4	8	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:119799820C>T	uc001ldj.1	-	2	1050	c.610G>A	c.(610-612)GAA>AAA	p.E204K	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.E204K	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	204					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		ATCTGTATTTCACCACTTGAA	0.413													0	0	0	0.003271	0	35	52										T	119799820	C	T	119799820	3	4	16	1	0	0	0	0	1	0	0	0	12894	835	29	1	944	1	RAB11FIP2	10	119799820	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7028318	119799820	15734927	381	4104										
EIF3A	8661	broad.mit.edu	37	chr10	120802040	120802040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcatcggcaattcgtctggGaggcctgtcatcatctgtgt	11	10	5	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:120802040G>A	uc001ldu.2	-	19	3138	c.2992C>T	c.(2992-2994)CCC>TCC	p.P998S	EIF3A_uc010qsu.1_Missense_Mutation_p.P964S|EIF3A_uc009xzg.1_Missense_Mutation_p.P37S	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	998	Asp-rich.|8.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		ATTCGTCTGGGAGGCCTGTCA	0.572													0	0	0	0.01441	0	61	94										A	120802040	G	A	120802040	3	1	16	1	0	0	0	0	1	0	0	0	5012	1174	41	1	1172	1	EIF3A	10	120802040	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1002220	120802040	14732707	382	4105										
SEC23IP	11196	broad.mit.edu	37	chr10	121652347	121652347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cggcgcctccacttcctcatCgggcactaacttacttttct	6	16	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:121652347C>T	uc001leu.1	+	1	125	c.53C>T	c.(52-54)TCG>TTG	p.S18L	SEC23IP_uc010qtc.1_5'UTR	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	18	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		ACTTCCTCATCGGGCACTAAC	0.627													0	0	0	0.00308	0	8	25										T	121652347	C	T	121652347	3	4	16	1	0	0	0	0	1	0	0	0	13993	893	31	1	55	1	SEC23IP	10	121652347	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	850307	121652347	13882400	383	4106										
SEC23IP	11196	broad.mit.edu	37	chr10	121671610	121671610	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgaatggggcaccacgcaaGatggacagacaaggcccagg	14	10	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:121671610G>A	uc001leu.1	+	6	1318	c.1246G>A	c.(1246-1248)GAT>AAT	p.D416N	SEC23IP_uc010qtc.1_Missense_Mutation_p.D205N	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	416					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CACCACGCAAGATGGACAGAC	0.433													0	0	0	0.00874	0	42	63										A	121671610	G	A	121671610	3	1	16	1	0	0	0	0	1	0	0	0	13993	942	33	1	1268	1	SEC23IP	10	121671610	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	19263	121671610	13863137	384	4107										
FGFR2	2263	broad.mit.edu	37	chr10	123258016	123258016	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcctcctactcaccatcctgTgtgcaggctccaagaagatt	7	14	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:123258016T>C	uc010qtk.1	-	13	2312	c.1665A>G	c.(1663-1665)ACA>ACG	p.T555T	FGFR2_uc010qtg.1_Silent_p.T443T|FGFR2_uc010qth.1_Silent_p.T440T|FGFR2_uc010qti.1_Silent_p.T466T|FGFR2_uc010qtj.1_Silent_p.T556T|FGFR2_uc010qtl.1_Silent_p.T439T|FGFR2_uc010qtm.1_Silent_p.T438T|FGFR2_uc001lfl.3_Silent_p.T556T|FGFR2_uc001lfm.2_Silent_p.T467T|FGFR2_uc001lfg.3_Silent_p.T163T	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	555	Cytoplasmic (Potential).|Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CACCATCCTGTGTGCAGGCTC	0.438		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.000602	0	5	43										C	123258016	T	C	123258016	2	2	16	1	0	0	0	0	0	0	0	1	5866	1683	59	5		5	FGFR2	10	123258016	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1586406	123258016	12276731	385	4108										
TACC2	10579	broad.mit.edu	37	chr10	123845111	123845111	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccactctggggcttgagtaaGagggagatggcaagtggaaa	16	6	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:123845111G>A	uc001lfv.2	+	4	3456	c.3096G>A	c.(3094-3096)AAG>AAA	p.K1032K	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.K1032K|TACC2_uc010qtv.1_Silent_p.K1032K	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1032						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCTTGAGTAAGAGGGAGATGG	0.582													0	0	0	0.001984	0	7	47										A	123845111	G	A	123845111	2	1	16	1	0	0	0	0	0	0	0	1	15499	933	33	1		1	TACC2	10	123845111	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	587095	123845111	11689636	386	4109										
FAM53B	9679	broad.mit.edu	37	chr10	126370704	126370704	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagggcctccatgatgtccgGcaactggacatctcatcgga	11	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:126370704G>A	uc001lhv.1	-	4	901	c.378C>T	c.(376-378)TGC>TGT	p.C126C	FAM53B_uc001lhu.1_Silent_p.C126C|FAM53B_uc001lhw.2_Silent_p.C126C	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	126										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		ATGATGTCCGGCAACTGGACA	0.602													0	0	0	0.004672	0	3	17										A	126370704	G	A	126370704	2	1	16	1	0	0	0	0	0	0	0	1	5580	1195	42	2		2	FAM53B	10	126370704	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2525593	126370704	9164043	387	4110										
JAKMIP3	282973	broad.mit.edu	37	chr10	133949530	133949530	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggatttgtctcatgctttaCgccgaatggaaaacaagtta	9	7	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:133949530C>T	uc001lkx.3	+	5	1066	c.1066C>T	c.(1066-1068)CGC>TGC	p.R356C		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCATGCTTTACGCCGAATGGA	0.527													0	0	0	0.003163	0	15	16										T	133949530	C	T	133949530	3	4	16	1	0	0	0	0	1	0	0	0	7942	536	19	2	1084	2	JAKMIP3	10	133949530	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7578826	133949530	1585217	388	4111										
ATHL1	80162	broad.mit.edu	37	chr11	294604	294604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggccggatacaaatgtcacCcccgaagctgcctggaagtt	11	12	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:294604C>T	uc010qvu.1	+	14	2184	c.2069C>T	c.(2068-2070)CCC>CTC	p.P690L	ATHL1_uc001lor.3_Missense_Mutation_p.P442L|ATHL1_uc001lou.3_Missense_Mutation_p.P265L|ATHL1_uc001lov.3_Missense_Mutation_p.P151L	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	690					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CAAATGTCACCCCCGAAGCTG	0.642													0	0	0	0.003954	0	27	124										T	294604	C	T	294604	3	4	16	1	0	0	0	0	1	0	0	0	1104	623	22	2	2119	2	ATHL1	11	294604	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08		294604	134711912	389	4112										
HRAS	3265	broad.mit.edu	37	chr11	534226	534226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctcacctctatagtggggtCgtattcgtccacaaaatggt	10	10	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:534226C>T	uc001lpv.2	-	2	285	c.97G>A	c.(97-99)GAC>AAC	p.D33N	HRAS_uc010qvw.1_Missense_Mutation_p.D33N|HRAS_uc010qvx.1_Missense_Mutation_p.D33N|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	33	Effector region.				activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	ATAGTGGGGTCGTATTCGTCC	0.637		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.013537	0	13	25										T	534226	C	T	534226	3	4	16	1	0	0	0	0	1	0	0	0	7348	884	31	1	555	1	HRAS	11	534226	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	239622	534226	134472290	390	4113										
TMEM80	283232	broad.mit.edu	37	chr11	703012	703012	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggccctcacggctggcacCgccctcctctctgcccactt	8	21	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:703012C>T	uc001lqr.2	+	5	506	c.369C>T	c.(367-369)ACC>ACT	p.T123T	TMEM80_uc001lqs.2_Silent_p.T115T|TMEM80_uc010qwi.1_Silent_p.T123T	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	123						integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGGCTGGCACCGCCCTCCTCT	0.692													0	0	0	0.013537	0	12	46										T	703012	C	T	703012	2	4	16	1	0	0	0	0	0	0	0	1	16201	639	23	2		2	TMEM80	11	703012	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	168786	703012	134303504	391	4114										
TALDO1	6888	broad.mit.edu	37	chr11	763392	763392	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcaacatgacgttactcttCtccttcgcccaggctgtggc	9	14	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:763392C>T	uc001lqz.2	+	5	560	c.510C>T	c.(508-510)TTC>TTT	p.F170F	TALDO1_uc001lra.2_Silent_p.F170F	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	170					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		CGTTACTCTTCTCCTTCGCCC	0.453													0	0	0	0.012213	0	31	55										T	763392	C	T	763392	2	4	16	1	0	0	0	0	0	0	0	1	15540	912	32	1		1	TALDO1	11	763392	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	60380	763392	134243124	392	4115										
DUSP8	1850	broad.mit.edu	37	chr11	1586951	1586951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgccagctgttgtactccaCgaaggagcggctgtcgatga	13	10	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:1586951C>T	uc001lts.2	-	2	234	c.106G>A	c.(106-108)GTG>ATG	p.V36M		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	36	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		TTGTACTCCACGAAGGAGCGG	0.657													0	0	0	0.004007	0	15	102										T	1586951	C	T	1586951	3	4	16	1	0	0	0	0	1	0	0	0	4831	536	19	2	1795	2	DUSP8	11	1586951	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	823559	1586951	133419565	393	4116										
MRGPRE	116534	broad.mit.edu	37	chr11	3249906	3249906	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagccagaggactgccccatTccccagcagcccaccgaggc	10	19	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:3249906T>C	uc001lxq.3	-	2	431	c.121A>G	c.(121-123)AAT>GAT	p.N41D		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	41	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGCCCCATTCCCCAGCAGC	0.642													0	0	0	0.008361	0	28	46										C	3249906	T	C	3249906	3	2	16	1	0	0	0	0	1	0	0	0	9764	1783	62	5	818	5	MRGPRE	11	3249906	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1662955	3249906	131756610	394	4117										
DENND5A	23258	broad.mit.edu	37	chr11	9161320	9161320	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgacaagtgtatggtctttGatcagtgccacatcctcata	8	9	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:9161320G>A	uc001mhl.2	-	23	4017	c.3762C>T	c.(3760-3762)ATC>ATT	p.I1254I	DENND5A_uc001mhk.2_Silent_p.I597I|DENND5A_uc010rbw.1_3'UTR	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	1254	RUN 2.									liver(1)	1						TATGGTCTTTGATCAGTGCCA	0.527													0	0	0	0.004482	0	9	25										A	9161320	G	A	9161320	2	1	16	1	0	0	0	0	0	0	0	1	4436	1280	45	1		1	DENND5A	11	9161320	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5911414	9161320	125845196	395	4118										
ADM	133	broad.mit.edu	37	chr11	10327902	10327902	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccggatgccgcccgcatccGagtcaagcgctaccgccaga	11	17	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:10327902G>A	uc001mik.1	+	3	889	c.272G>A	c.(271-273)CGA>CAA	p.R91Q	ADM_uc001mil.1_Missense_Mutation_p.R91Q|ADM_uc001mim.1_Missense_Mutation_p.R44Q	NM_001124	NP_001115	P35318	ADML_HUMAN	adrenomedullin precursor	91					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)	1				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		GCCCGCATCCGAGTCAAGCGC	0.647													0	0	0	0.012319	0	20	23										A	10327902	G	A	10327902	3	1	16	1	0	0	0	0	1	0	0	0	321	1058	37	1	282	1	ADM	11	10327902	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1166582	10327902	124678614	396	4119										
USP47	55031	broad.mit.edu	37	chr11	11971470	11971470	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctagatgctgtgtttgctaAaggaatgactgtacggcaat	12	6	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:11971470A>G	uc001mjs.2	+	23	4146	c.3383A>G	c.(3382-3384)AAA>AGA	p.K1128R	USP47_uc001mjr.2_Missense_Mutation_p.K1060R|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1148					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		GTGTTTGCTAAAGGAATGACT	0.343													0	0	0	0.010729	0	11	29										G	11971470	A	G	11971470	3	3	16	1	0	0	0	0	1	0	0	0	17075	14	1	5	3265	5	USP47	11	11971470	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1643568	11971470	123035046	397	4120										
PDE3B	5140	broad.mit.edu	37	chr11	14666332	14666332	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgggtctccttcaccagcctCgggtcgctgccctccgccct	10	19	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:14666332C>T	uc001mln.2	+	1	1064	c.711C>T	c.(709-711)CTC>CTT	p.L237L	PDE3B_uc001mlm.2_Silent_p.L237L|PDE3B_uc010rcr.1_Silent_p.L237L|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	237	Helical; (Potential).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						TCACCAGCCTCGGGTCGCTGC	0.692													0	0	0	0.00308	0	7	22										T	14666332	C	T	14666332	2	4	16	1	0	0	0	0	0	0	0	1	11638	871	31	1		1	PDE3B	11	14666332	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2694862	14666332	120340184	398	4121										
CYP2R1	120227	broad.mit.edu	37	chr11	14913753	14913753	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctctccaaagcttccacatcGgcccgagctggaggtgcgaa	11	14	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:14913753G>C	uc001mlr.2	-	1	1	c.1_splice	c.e1-1	p.M1_splice	CYP2R1_uc001mlo.2_5'Flank|CYP2R1_uc001mlp.2_5'Flank|CYP2R1_uc001mlq.2_5'Flank	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,						hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CTTCCACATCGGCCCGAGCTG	0.677													0	0	0	0.009096	0	3	16										C	14913753	G	C	14913753	5	2	16	1	0	0	0	0	0	0	1	0	4173	1131	39	4	1526	4	CYP2R1	11	14913753	Splice_Site	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	247421	14913753	120092763	399	4122										
CCDC34	91057	broad.mit.edu	37	chr11	27360567	27360567	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggctggttctggataggaaTttccactgtaaaaacctaaa	9	7	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:27360567T>C	uc001mrh.1	-	6	977	c.923A>G	c.(922-924)AAT>AGT	p.N308S		NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	308											0						TGGATAGGAATTTCCACTGTA	0.338													0	0	0	0.00308	0	8	37										C	27360567	T	C	27360567	3	2	16	1	0	0	0	0	1	0	0	0	2807	1493	52	5	202	5	CCDC34	11	27360567	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	12446814	27360567	107645949	400	4123										
LGR4	55366	broad.mit.edu	37	chr11	27389570	27389570	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcagagtgggccgactgtgtGccacagtcggaccagtagcc	14	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:27389570G>A	uc001mrj.3	-	18	3185	c.2700C>T	c.(2698-2700)GGC>GGT	p.G900G	LGR4_uc001mrk.3_Silent_p.G876G	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	900	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						CCGACTGTGTGCCACAGTCGG	0.512													0	0	0	0.014323	0	24	44										A	27389570	G	A	27389570	2	1	16	1	0	0	0	0	0	0	0	1	8756	1306	46	2		2	LGR4	11	27389570	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	29003	27389570	107616946	401	4124										
WT1	7490	broad.mit.edu	37	chr11	32410605	32410605	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggtccccgagggagacccctCaaagcgccagctggagtttg	14	13	1	1	rs148856160		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:32410605C>G	uc001mtn.1	-	10	1749	c.1553G>C	c.(1552-1554)TGA>TCA	p.*518S	WT1_uc001mtl.1_Nonstop_Mutation_p.*303S|WT1_uc001mtm.1_Nonstop_Mutation_p.*289S|WT1_uc001mto.1_Nonstop_Mutation_p.*515S|WT1_uc001mtp.1_Nonstop_Mutation_p.*501S|WT1_uc001mtq.1_Nonstop_Mutation_p.*498S|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	518					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GGAGACCCCTCAAAGCGCCAG	0.517			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				0	0	0	0.004656	0	25	30										G	32410605	C	G	32410605	4	3	16	1	0	0	0	0	0	0	0	0	17405	837	29	1	4	1	WT1	11	32410605	Nonstop_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5021035	32410605	102595911	402	4125										
HIPK3	10114	broad.mit.edu	37	chr11	33361046	33361046	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgaaccatccttttgttaatAtgaaacatcttctagatttc	4	8	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:33361046A>G	uc001mul.1	+	6	1849	c.1579A>G	c.(1579-1581)ATG>GTG	p.M527V	HIPK3_uc001mum.1_Missense_Mutation_p.M527V|HIPK3_uc009yjv.1_Missense_Mutation_p.M527V	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	527					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TTTTGTTAATATGAAACATCT	0.323													0	0	0	0.004656	0	22	88										G	33361046	A	G	33361046	3	3	16	1	0	0	0	0	1	0	0	0	7118	449	16	5	1597	5	HIPK3	11	33361046	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	950441	33361046	101645470	403	4126										
OR4C15	81309	broad.mit.edu	37	chr11	55322644	55322644	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagttctgaagggcgctggAaagctctctccacctgtgga	12	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:55322644A>G	uc010rig.1	+	1	862	c.862A>G	c.(862-864)AAA>GAA	p.K288E		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGGGCGCTGGAAAGCTCTCTC	0.443										HNSCC(20;0.049)			0	0	0	0.007291	0	25	104										G	55322644	A	G	55322644	3	3	16	1	0	0	0	0	1	0	0	0	11048	247	9	5	864	5	OR4C15	11	55322644	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	21961598	55322644	79683872	404	4127										
OR8H1	219469	broad.mit.edu	37	chr11	56058202	56058202	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ataggccattgatgagagaaGaaaacattcagcagctccca	9	9	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:56058202G>T	uc010rje.1	-	1	337	c.337C>A	c.(337-339)CTT>ATT	p.L113I		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GATGAGAGAAGAAAACATTCA	0.438													1	0	2.12542e-12	0.00632	2.27309e-12	28	92										T	56058202	G	T	56058202	3	4	16	1	0	0	0	0	1	0	0	0	11237	942	33	3	600	3	OR8H1	11	56058202	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	735558	56058202	78948314	405	4128										
PRG2	5553	broad.mit.edu	37	chr11	57156559	57156559	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acccagggatgcccaccactTttactgtgtcctcttcctca	6	16	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:57156559T>G	uc001njz.2	-	2	317	c.290A>C	c.(289-291)AAA>ACA	p.K97T	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.K97T|PRG2_uc001nkb.2_Missense_Mutation_p.K97T|PRG2_uc001nkd.2_Missense_Mutation_p.K97T|PRG2_uc001nkc.2_Missense_Mutation_p.K97T|PRG2_uc001nke.2_Missense_Mutation_p.K377T	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	97					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	GCCCACCACTTTTACTGTGTC	0.527													0	0	0	0.010504	0	20	99										G	57156559	T	G	57156559	3	3	16	1	0	0	0	0	1	0	0	0	12479	1841	64	5	394	5	PRG2	11	57156559	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1098357	57156559	77849957	406	4129										
ZDHHC5	25921	broad.mit.edu	37	chr11	57467491	57467491	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttggtggtaccacctatgaGatttcggtgtgagccttcgg	14	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:57467491G>A	uc001nkx.1	+	12	3392	c.2136G>A	c.(2134-2136)GAG>GAA	p.E712E	ZDHHC5_uc001nky.1_Silent_p.E659E|ZDHHC5_uc001nkz.1_Silent_p.E526E	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	712						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						CCACCTATGAGATTTCGGTGT	0.647													0	0	0	0.008291	0	11	10										A	57467491	G	A	57467491	2	1	16	1	0	0	0	0	0	0	0	1	17615	933	33	1		1	ZDHHC5	11	57467491	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	310932	57467491	77539025	407	4130										
ZFP91	80829	broad.mit.edu	37	chr11	58384270	58384270	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtgcaccggatgattcacaCtggcgagaagccattacagt	11	10	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:58384270C>A	uc001nmx.3	+	10	1352	c.1184C>A	c.(1183-1185)ACT>AAT	p.T395N	ZFP91_uc001nmy.3_Missense_Mutation_p.T394N|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	395					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ATGATTCACACTGGCGAGAAG	0.423													1	0	0.000274275	0.004482	0.000284165	7	36										A	58384270	C	A	58384270	3	1	16	1	0	0	0	0	1	0	0	0	17652	565	20	4	1222	4	ZFP91	11	58384270	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	916779	58384270	76622246	408	4131										
ZFP91	80829	broad.mit.edu	37	chr11	58384283	58384283	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attcacactggcgagaagccAttacagtgagtattatttac	8	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:58384283A>G	uc001nmx.3	+	10	1365	c.1197A>G	c.(1195-1197)CCA>CCG	p.P399P	ZFP91_uc001nmy.3_Silent_p.P398P|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	399					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCGAGAAGCCATTACAGTGAG	0.438													0	0	0	0.006214	0	9	35										G	58384283	A	G	58384283	2	3	16	1	0	0	0	0	0	0	0	1	17652	204	8	5		5	ZFP91	11	58384283	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	13	58384283	76622233	409	4132										
MS4A14	84689	broad.mit.edu	37	chr11	60184148	60184148	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatcagcaagctgaagatcaGcaagccaaaggggaacaata	11	8	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:60184148G>A	uc001npj.2	+	5	2272	c.1707G>A	c.(1705-1707)CAG>CAA	p.Q569Q	MS4A14_uc001npi.2_Silent_p.Q457Q|MS4A14_uc001npn.2_Silent_p.Q307Q|MS4A14_uc001npk.2_Silent_p.Q552Q|MS4A14_uc001npl.2_Silent_p.Q307Q|MS4A14_uc001npm.2_Silent_p.Q307Q	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	569	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CTGAAGATCAGCAAGCCAAAG	0.438													0	0	0	0.004007	0	17	8										A	60184148	G	A	60184148	2	1	16	1	0	0	0	0	0	0	0	1	9858	962	34	2		2	MS4A14	11	60184148	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1799865	60184148	74822368	410	4133										
DAK	26007	broad.mit.edu	37	chr11	61111381	61111381	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggctgcagtctccattactGggcggaagcggagccgggta	16	10	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:61111381G>A	uc001nre.2	+	12	1293	c.1036G>A	c.(1036-1038)GGG>AGG	p.G346R	DDB1_uc010rlf.1_5'Flank|DAK_uc009ynm.1_Missense_Mutation_p.G276R	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	346					glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						CTCCATTACTGGGCGGAAGCG	0.622													0	0	0	0.00245	0	15	83										A	61111381	G	A	61111381	3	1	16	1	0	0	0	0	1	0	0	0	4228	1348	47	2	1078	2	DAK	11	61111381	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	927233	61111381	73895135	411	4134										
SYT7	9066	broad.mit.edu	37	chr11	61318925	61318925	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccgtctccaaggaattcttgTagcgtttgccctgtggagat	11	10	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:61318925T>C	uc001nrv.2	-	3	152	c.146A>G	c.(145-147)TAC>TGC	p.Y49C	SYT7_uc009ynr.2_Missense_Mutation_p.Y49C|SYT7_uc001nrx.1_RNA	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	49	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						GGAATTCTTGTAGCGTTTGCC	0.587													0	0	0	0.001855	0	12	63										C	61318925	T	C	61318925	3	2	16	1	0	0	0	0	1	0	0	0	15476	1638	57	5	1093	5	SYT7	11	61318925	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	207544	61318925	73687591	412	4135										
DAGLA	747	broad.mit.edu	37	chr11	61511362	61511362	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcactgagctgctggcggccGacagcctgtccaagcactca	12	15	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:61511362G>A	uc001nsa.2	+	20	2641	c.2530G>A	c.(2530-2532)GAC>AAC	p.D844N		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	844	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GCTGGCGGCCGACAGCCTGTC	0.667													0	0	0	0.01441	0	105	166										A	61511362	G	A	61511362	3	1	16	1	0	0	0	0	1	0	0	0	4226	1058	37	1	2604	1	DAGLA	11	61511362	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	192437	61511362	73495154	413	4136										
MARK2	2011	broad.mit.edu	37	chr11	63672397	63672397	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgggcagctccgacaggtgCgggaccagcagaatttgccc	14	13	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:63672397C>T	uc001nxw.2	+	16	2395	c.1816C>T	c.(1816-1818)CGG>TGG	p.R606W	MARK2_uc001nxx.2_Missense_Mutation_p.R552W|MARK2_uc001nxy.2_Missense_Mutation_p.R551W|MARK2_uc001nxv.3_Missense_Mutation_p.R551W|MARK2_uc001nxz.3_Missense_Mutation_p.R572W|MARK2_uc009yoy.2_Missense_Mutation_p.R526W	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	606					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCGACAGGTGCGGGACCAGCA	0.647													0	0	0	0.001168	0	5	86										T	63672397	C	T	63672397	3	4	16	1	0	0	0	0	1	0	0	0	9313	759	27	2	1878	2	MARK2	11	63672397	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2161035	63672397	71334119	414	4137										
PLCB3	5331	broad.mit.edu	37	chr11	64023082	64023082	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaatcctgtggcctcaaattCaaccgggtgtgtggggtggg	16	8	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:64023082C>T	uc001nzb.2	+	7	591	c.591C>T	c.(589-591)TTC>TTT	p.F197F	PLCB3_uc009ypg.1_Silent_p.F197F|PLCB3_uc009yph.1_Silent_p.F130F|PLCB3_uc009ypi.2_Silent_p.F197F	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	197					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GCCTCAAATTCAACCGGGTGT	0.642													0	0	0	0.010818	0	29	37										T	64023082	C	T	64023082	2	4	16	1	0	0	0	0	0	0	0	1	12029	825	29	1		1	PLCB3	11	64023082	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	350685	64023082	70983434	415	4138										
PRDX5	25824	broad.mit.edu	37	chr11	64085722	64085722	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgtgtgcgccctgagacgctCagcgggctatatactcgtcg	13	13	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:64085722C>T	uc001nzu.2	+	1	154	c.35C>T	c.(34-36)TCA>TTA	p.S12L	TRMT112_uc001nzt.2_5'Flank|PRDX5_uc001nzv.2_Missense_Mutation_p.S12L|PRDX5_uc001nzw.2_Missense_Mutation_p.S12L|PRDX5_uc001nzx.2_5'Flank	NM_012094	NP_036226	P30044	PRDX5_HUMAN	peroxiredoxin 5 isoform a precursor	12					cell redox homeostasis|cellular response to reactive oxygen species|inflammatory response|negative regulation of apoptosis	cytosolic part|mitochondrion|peroxisome	caspase inhibitor activity|peroxidase activity|peroxiredoxin activity			breast(1)	1					Auranofin(DB00995)	CTGAGACGCTCAGCGGGCTAT	0.697													0	0	0	0.001984	0	6	39										T	64085722	C	T	64085722	3	4	16	1	0	0	0	0	1	0	0	0	12468	838	29	1	37	1	PRDX5	11	64085722	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	62640	64085722	70920794	416	4139										
ATG2A	23130	broad.mit.edu	37	chr11	64669497	64669497	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgtccagggtgtctccatcGccctcctcttccctttcatc	6	18	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:64669497G>A	uc001obx.2	-	29	4171	c.4056C>T	c.(4054-4056)GGC>GGT	p.G1352G	ATG2A_uc001obw.2_Silent_p.G117G	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1352							protein binding			ovary(1)|central_nervous_system(1)	2						TGTCTCCATCGCCCTCCTCTT	0.627													0	0	0	0.006214	0	8	95										A	64669497	G	A	64669497	2	1	16	1	0	0	0	0	0	0	0	1	1093	1074	38	2		2	ATG2A	11	64669497	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	583775	64669497	70337019	417	4140										
DPP3	10072	broad.mit.edu	37	chr11	66272161	66272161	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagtcactgatgcgccccccGagtgcttcctcaccctcagg	9	18	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:66272161G>A	uc001oig.1	+	17	2019	c.1957G>A	c.(1957-1959)GAG>AAG	p.E653K	DPP3_uc001oif.1_Missense_Mutation_p.E653K|DPP3_uc010rpe.1_Missense_Mutation_p.E642K|DPP3_uc001oih.1_Silent_p.P20P	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	653					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TGCGCCCCCCGAGTGCTTCCT	0.572													0	0	0	0.004656	0	28	73										A	66272161	G	A	66272161	3	1	16	1	0	0	0	0	1	0	0	0	4728	1059	37	1	2019	1	DPP3	11	66272161	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1602664	66272161	68734355	418	4141										
PC	5091	broad.mit.edu	37	chr11	66617203	66617203	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	catcggggtacatagctgctGagagcacatcttccggcgtc	12	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:66617203G>A	uc001ojn.1	-	19	3075	c.3026C>T	c.(3025-3027)TCA>TTA	p.S1009L	PC_uc001ojo.1_Missense_Mutation_p.S1009L|PC_uc001ojp.1_Missense_Mutation_p.S1009L|PC_uc001ojm.1_5'UTR	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	1009					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CATAGCTGCTGAGAGCACATC	0.622													0	0	0	0.006214	0	9	43										A	66617203	G	A	66617203	3	1	16	1	0	0	0	0	1	0	0	0	11497	1294	45	1	522	1	PC	11	66617203	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	345042	66617203	68389313	419	4142										
RAD9A	5883	broad.mit.edu	37	chr11	67161232	67161232	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccgtcttcgacccagcctcGtgcccccacatgctccgcgc	9	21	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:67161232G>A	uc001okr.2	+	5	513	c.420G>A	c.(418-420)TCG>TCA	p.S140S	RAD9A_uc001oks.2_5'Flank	NM_004584	NP_004575	Q99638	RAD9A_HUMAN	RAD9 homolog	140					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding				0			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			ACCCAGCCTCGTGCCCCCACA	0.652								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.000602	0	5	9										A	67161232	G	A	67161232	2	1	16	1	0	0	0	0	0	0	0	1	12995	1132	40	2		2	RAD9A	11	67161232	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	544029	67161232	67845284	420	4143										
C2CD3	26005	broad.mit.edu	37	chr11	73849870	73849870	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggaattcagaactgttcaGaagggacatctgcttccgtg	11	9	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:73849870G>A	uc001ouu.2	-	5	1077	c.850C>T	c.(850-852)CTG>TTG	p.L284L	C2CD3_uc001ouv.2_Silent_p.L284L	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	284						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GAACTGTTCAGAAGGGACATC	0.438													0	0	0	0.001984	0	7	43										A	73849870	G	A	73849870	2	1	16	1	0	0	0	0	0	0	0	1	2154	933	33	1		1	C2CD3	11	73849870	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6688638	73849870	61156646	421	4144										
C11orf82	220042	broad.mit.edu	37	chr11	82643785	82643785	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgtgactccccagagaactActggagccctgcatacacca	8	15	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:82643785A>T	uc001ozt.2	+	6	1649	c.1405A>T	c.(1405-1407)ACT>TCT	p.T469S	C11orf82_uc010rsr.1_Missense_Mutation_p.T168S|C11orf82_uc010rss.1_Missense_Mutation_p.T168S|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	469					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						CCAGAGAACTACTGGAGCCCT	0.403													0	0	0	0.010504	0	19	25										T	82643785	A	T	82643785	3	4	16	1	0	0	0	0	1	0	0	0	1665	391	14	5	1419	5	C11orf82	11	82643785	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	8793915	82643785	52362731	422	4145										
AMOTL1	154810	broad.mit.edu	37	chr11	94554952	94554952	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gggtgcttcaccaggaacttCagggttactacgacaatgcc	11	11	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:94554952C>T	uc001pfb.2	+	4	1548	c.1378C>T	c.(1378-1380)CAG>TAG	p.Q460*	AMOTL1_uc001pfc.2_Nonsense_Mutation_p.Q410*	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	460	Potential.			LQ -> HE (in Ref. 2; AAH14126).		cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCAGGAACTTCAGGGTTACTA	0.537													0	0	0	0.012213	0	27	33										T	94554952	C	T	94554952	4	4	16	1	0	0	0	0	0	1	0	0	583	827	29	1	1392	1	AMOTL1	11	94554952	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	11911167	94554952	40451564	423	4146										
EXPH5	23086	broad.mit.edu	37	chr11	108383163	108383163	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgagaaaactgcttgattttCttggcaaggtacaataaatt	8	5	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:108383163C>G	uc001pkk.2	-	6	3182	c.3071G>C	c.(3070-3072)AGA>ACA	p.R1024T	EXPH5_uc010rvy.1_Missense_Mutation_p.R836T|EXPH5_uc010rvz.1_Missense_Mutation_p.R868T|EXPH5_uc010rwa.1_Missense_Mutation_p.R948T	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1024					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GCTTGATTTTCTTGGCAAGGT	0.398													0	0	0	0.014323	0	21	23										G	108383163	C	G	108383163	3	3	16	1	0	0	0	0	1	0	0	0	5322	913	32	1	2902	1	EXPH5	11	108383163	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	13828211	108383163	26623353	424	4147										
C11orf53	341032	broad.mit.edu	37	chr11	111154990	111154990	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttcccccaggagccctacgGagactaccggcctccggcgc	11	19	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:111154990G>A	uc001plc.2	+	3	344	c.197G>A	c.(196-198)GGA>GAA	p.G66E		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	66											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		GAGCCCTACGGAGACTACCGG	0.697													0	0	0	0.009718	0	44	28										A	111154990	G	A	111154990	3	1	16	1	0	0	0	0	1	0	0	0	1648	1174	41	1	203	1	C11orf53	11	111154990	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2771827	111154990	23851526	425	4148										
MLL	4297	broad.mit.edu	37	chr11	118359411	118359411	+	Frame_Shift_Del	DEL	A	A	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccctctggaggaccagctggAaaattggtgttgtcgtcgtt							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:118359411delA	uc001pta.2	+	11	4438	c.4415delA	c.(4414-4416)GAAfs	p.E1472fs	MLL_uc001ptb.2_Frame_Shift_Del_p.E1472fs|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1472	PHD-type 1.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GACCAGCTGGAAAATTGGTGT	0.418			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL													24	28	---	---								-	118359411	A	-	118359411	7	5	16	1	0	1	0	1	0	0	0	0	9620	246	9	0	4457	0	MLL	11	118359411	Frame_Shift_Del	DEL	A	TCGA-BT-A2LB-01A-11D-A18F-08	7204421	118359411	16647105	426	4149										
SNX19	399979	broad.mit.edu	37	chr11	130773221	130773221	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtacatagccatttccactgTtctgttagtagcaagaggag	10	8	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:130773221T>C	uc001qgk.3	-	8	3050	c.2502A>G	c.(2500-2502)GAA>GAG	p.E834E	SNX19_uc009zcw.2_Silent_p.E71E|SNX19_uc010sce.1_Silent_p.E214E|SNX19_uc010scf.1_Silent_p.E277E|SNX19_uc010scg.1_Silent_p.E71E	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	834					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ATTTCCACTGTTCTGTTAGTA	0.453													0	0	0	0.00499	0	18	24										C	130773221	T	C	130773221	2	2	16	1	0	0	0	0	0	0	0	1	14890	1722	60	5		5	SNX19	11	130773221	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	12413810	130773221	4233295	427	4150										
RAD52	5893	broad.mit.edu	37	chr12	1025884	1025884	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacctgctgcagctgtgggtGtcccagggccatgttcggtc	14	13	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:1025884G>A	uc001qis.1	-	8	760	c.646C>T	c.(646-648)CAC>TAC	p.H216Y	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.H139Y|RAD52_uc001qiu.1_Missense_Mutation_p.H216Y|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Missense_Mutation_p.H216Y	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	216					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			AGCTGTGGGTGTCCCAGGGCC	0.582								Homologous_recombination					0	0	0	0.001855	0	13	42										A	1025884	G	A	1025884	3	1	16	1	0	0	0	0	1	0	0	0	12991	1377	48	2	630	2	RAD52	12	1025884	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		1025884	132826011	428	4151										
CACNA2D4	93589	broad.mit.edu	37	chr12	2017134	2017134	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attggactccaggaggaactCggcgcccagctccacgaagt	12	13	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:2017134C>T	uc001qjp.2	-	5	787	c.556G>A	c.(556-558)GAG>AAG	p.E186K	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.E186K	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	186	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AGGAGGAACTCGGCGCCCAGC	0.602													0	0	0	0.010504	0	20	42										T	2017134	C	T	2017134	3	4	16	1	0	0	0	0	1	0	0	0	2551	893	31	1	2993	1	CACNA2D4	12	2017134	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	991250	2017134	131834761	429	4152										
CACNA1C	775	broad.mit.edu	37	chr12	2795357	2795357	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agggcctccttccacctggaAtgtctgaagcgacagaagga	12	11	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:2795357A>G	uc009zdu.1	+	48	6268	c.5955A>G	c.(5953-5955)GAA>GAG	p.E1985E	CACNA1C_uc009zdv.1_Silent_p.E1899E|CACNA1C_uc001qkb.2_Silent_p.E1902E|CACNA1C_uc001qkc.2_Silent_p.E1921E|CACNA1C_uc001qke.2_Silent_p.E1891E|CACNA1C_uc001qkf.2_Silent_p.E1910E|CACNA1C_uc001qjz.2_Silent_p.E1902E|CACNA1C_uc001qkd.2_Silent_p.E1921E|CACNA1C_uc001qkg.2_Silent_p.E1908E|CACNA1C_uc009zdw.1_Silent_p.E1943E|CACNA1C_uc001qkh.2_Silent_p.E1910E|CACNA1C_uc001qkl.2_Silent_p.E1950E|CACNA1C_uc001qkn.2_Silent_p.E1902E|CACNA1C_uc001qko.2_Silent_p.E1922E|CACNA1C_uc001qkp.2_Silent_p.E1902E|CACNA1C_uc001qkr.2_Silent_p.E1919E|CACNA1C_uc001qku.2_Silent_p.E1937E|CACNA1C_uc001qkq.2_Silent_p.E1930E|CACNA1C_uc001qks.2_Silent_p.E1902E|CACNA1C_uc001qkt.2_Silent_p.E1921E|CACNA1C_uc001qki.1_Silent_p.E1709E|CACNA1C_uc001qkj.1_Silent_p.E1673E|CACNA1C_uc001qkk.1_Silent_p.E1638E|CACNA1C_uc001qkm.1_Silent_p.E1698E|CACNA1C_uc010sea.1_Silent_p.E593E|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Silent_p.E220E	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1985	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCACCTGGAATGTCTGAAGC	0.562													0	0	0	0.004656	0	25	81										G	2795357	A	G	2795357	2	3	16	1	0	0	0	0	0	0	0	1	2540	98	4	5		5	CACNA1C	12	2795357	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	778223	2795357	131056538	430	4153										
TNFRSF1A	7132	broad.mit.edu	37	chr12	6442925	6442925	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttcggcatttggagcagctGaggcagtgtctgaggtggtt	16	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:6442925G>A	uc001qnu.2	-	3	581	c.300C>T	c.(298-300)CTC>CTT	p.L100L	TNFRSF1A_uc001qnt.2_5'UTR|TNFRSF1A_uc010sey.1_Intron|TNFRSF1A_uc010sez.1_5'UTR|TNFRSF1A_uc009zek.2_Intron|TNFRSF1A_uc010sfa.1_Silent_p.L100L	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	100	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						TGGAGCAGCTGAGGCAGTGTC	0.592													0	0	0	0.004672	0	3	3										A	6442925	G	A	6442925	2	1	16	1	0	0	0	0	0	0	0	1	16290	1277	45	1		1	TNFRSF1A	12	6442925	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3647568	6442925	127408970	431	4154										
NOP2	4839	broad.mit.edu	37	chr12	6675746	6675746	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcaggagacttatttgtctTaggggcttcaacagagccca	10	10	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:6675746T>C	uc001qpk.1	-	3	231	c.187A>G	c.(187-189)AAG>GAG	p.K63E	NOP2_uc001qph.1_Missense_Mutation_p.K63E|NOP2_uc001qpi.1_Missense_Mutation_p.K63E|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Missense_Mutation_p.K63E|NOP2_uc001qpm.1_Missense_Mutation_p.K63E			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	63					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						TTATTTGTCTTAGGGGCTTCA	0.488													0	0	0	0.00632	0	25	34										C	6675746	T	C	6675746	3	2	16	1	0	0	0	0	1	0	0	0	10538	1763	61	5	2291	5	NOP2	12	6675746	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	232821	6675746	127176149	432	4155										
C1R	715	broad.mit.edu	37	chr12	7244200	7244200	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagaggggaagtcacctcccCaaataacttctgagggatgg	12	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:7244200C>T	uc010sfy.1	-	2	138	c.79G>A	c.(79-81)GGG>AGG	p.G27R	C1R_uc010sfz.1_Missense_Mutation_p.G41R|C1R_uc010sga.1_Missense_Mutation_p.G27R	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	27	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTCACCTCCCCAAATAACTTC	0.537													0	0	0	0.009096	0	4	3										T	7244200	C	T	7244200	3	4	16	1	0	0	0	0	1	0	0	0	1972	594	21	2	1757	2	C1R	12	7244200	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	568454	7244200	126607695	433	4156										
DUSP16	80824	broad.mit.edu	37	chr12	12674023	12674023	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aatttgagttccaatcatctCatgggccatgacaacaataa	6	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:12674023C>T	uc001rao.1	-	2	642	c.10G>A	c.(10-12)GAG>AAG	p.E4K	DUSP16_uc001ran.1_5'UTR	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	4					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CCAATCATCTCATGGGCCATG	0.453													0	0	0	0.010729	0	11	17										T	12674023	C	T	12674023	3	4	16	1	0	0	0	0	1	0	0	0	4816	835	29	1	2011	1	DUSP16	12	12674023	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5429823	12674023	121177872	434	4157										
PDE3A	5139	broad.mit.edu	37	chr12	20523043	20523043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagcatttggggtcccagctGattgctgggaccaaggaaga	15	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:20523043G>A	uc001reh.1	+	1	847	c.825G>A	c.(823-825)CTG>CTA	p.L275L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627													0	0	0	0.008361	0	23	41										A	20523043	G	A	20523043	2	1	16	1	0	0	0	0	0	0	0	1	11637	1277	45	1		1	PDE3A	12	20523043	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7849020	20523043	113328852	435	4158										
PDE3A	5139	broad.mit.edu	37	chr12	20799433	20799433	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actggttacagatcataacaGaatccatgccactgatgttt	7	9	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:20799433G>A	uc001reh.1	+	11	2283	c.2261G>A	c.(2260-2262)AGA>AAA	p.R754K		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	754	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GATCATAACAGAATCCATGCC	0.413													0	0	0	0.008361	0	27	35										A	20799433	G	A	20799433	3	1	16	1	0	0	0	0	1	0	0	0	11637	942	33	1	2303	1	PDE3A	12	20799433	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	276390	20799433	113052462	436	4159										
DENND5B	160518	broad.mit.edu	37	chr12	31595714	31595714	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaagaacatgcttacttgttActggttggtcctgttgccaa	10	8	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:31595714A>C	uc001rki.1	-	7	2193	c.2007T>G	c.(2005-2007)AGT>AGG	p.S669R	DENND5B_uc001rkh.1_Missense_Mutation_p.S704R|DENND5B_uc009zjq.1_Intron|DENND5B_uc001rkj.2_Missense_Mutation_p.S691R	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	669						integral to membrane				ovary(1)|central_nervous_system(1)	2						CTTACTTGTTACTGGTTGGTC	0.418													0	0	0	0.001984	0	6	20										C	31595714	A	C	31595714	3	2	16	1	0	0	0	0	1	0	0	0	4437	388	14	5	1877	5	DENND5B	12	31595714	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	10796281	31595714	102256181	437	4160										
YARS2	51067	broad.mit.edu	37	chr12	32906904	32906904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaattgatacaattcaaatgGagatgtcttatctctgttta	7	5	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:32906904G>A	uc001rli.2	-	2	961	c.895C>T	c.(895-897)CCA>TCA	p.P299S		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	299					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	AATTCAAATGGAGATGTCTTA	0.418													0	0	0	0.003755	0	33	69										A	32906904	G	A	32906904	3	1	16	1	0	0	0	0	1	0	0	0	17465	1174	41	1	554	1	YARS2	12	32906904	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1311190	32906904	100944991	438	4161										
SLC2A13	114134	broad.mit.edu	37	chr12	40499284	40499284	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccagactgagctgccgcttGagcagcagcatggcccctga	12	14	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:40499284G>A	uc010skm.1	-	1	378	c.327C>T	c.(325-327)CTC>CTT	p.L109L	SLC2A13_uc001rmf.2_Silent_p.L109L	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	109	Extracellular (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				GCTGCCGCTTGAGCAGCAGCA	0.697										HNSCC(50;0.14)			0	0	0	0.004672	0	3	3										A	40499284	G	A	40499284	2	1	16	1	0	0	0	0	0	0	0	1	14542	1277	45	1		1	SLC2A13	12	40499284	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7592380	40499284	93352611	439	4162										
LRRK2	120892	broad.mit.edu	37	chr12	40748212	40748212	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctctcctggtcatcaataccGaagatgggaaaaagagacat	9	9	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:40748212G>A	uc001rmg.3	+	45	6809	c.6688G>A	c.(6688-6690)GAA>AAA	p.E2230K	LRRK2_uc009zjw.2_Missense_Mutation_p.E1068K|LRRK2_uc001rmi.2_Missense_Mutation_p.E1063K	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2230					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CATCAATACCGAAGATGGGAA	0.408													0	0	0	0.00308	0	8	23										A	40748212	G	A	40748212	3	1	16	1	0	0	0	0	1	0	0	0	9033	1059	37	1	6866	1	LRRK2	12	40748212	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	248928	40748212	93103683	440	4163										
CNTN1	1272	broad.mit.edu	37	chr12	41327360	41327360	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttagaatgttttgcacttggAaagtaagtatactgacactt	8	5	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:41327360A>T	uc001rmm.1	+	8	914	c.801A>T	c.(799-801)GGA>GGT	p.G267G	CNTN1_uc009zjy.1_Silent_p.G267G|CNTN1_uc001rmn.1_Silent_p.G256G|CNTN1_uc001rmo.2_Silent_p.G267G	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	267	Ig-like C2-type 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTGCACTTGGAAAGTAAGTAT	0.284													0	0	0	0.00333	0	24	67										T	41327360	A	T	41327360	2	4	16	1	0	0	0	0	0	0	0	1	3640	233	9	5		5	CNTN1	12	41327360	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	579148	41327360	92524535	441	4164										
ARID2	196528	broad.mit.edu	37	chr12	46287315	46287315	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatcaagaaaccttgtctttCgagattttacagtaagcatg	8	7	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:46287315C>T	uc001ros.1	+	19	5260	c.5260C>T	c.(5260-5262)CGA>TGA	p.R1754*	ARID2_uc001ror.2_Nonsense_Mutation_p.R1754*|ARID2_uc009zkg.1_Nonsense_Mutation_p.R1210*|ARID2_uc009zkh.1_Nonsense_Mutation_p.R1381*|ARID2_uc001rou.1_Nonsense_Mutation_p.R1088*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1754					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCTTGTCTTTCGAGATTTTAC	0.403													0	0	0	0.005443	0	26	36										T	46287315	C	T	46287315	4	4	16	1	0	0	0	0	0	1	0	0	915	876	31	1	5334	1	ARID2	12	46287315	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4959955	46287315	87564580	442	4165										
H1FNT	341567	broad.mit.edu	37	chr12	48723371	48723371	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagagcggccgccacgaagcGcccagggggcaggccaaggc	17	14	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:48723371G>A	uc001rrm.2	+	1	609	c.297G>A	c.(295-297)GCG>GCA	p.A99A		NM_181788	NP_861453	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	99					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			pancreas(1)	1						GCCACGAAGCGCCCAGGGGGC	0.667													0	0	0	0.00278	0	17	19										A	48723371	G	A	48723371	2	1	16	1	0	0	0	0	0	0	0	1	6921	1074	38	2		2	H1FNT	12	48723371	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2436056	48723371	85128524	443	4166										
TROAP	10024	broad.mit.edu	37	chr12	49719543	49719543	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtcccagggtgttcgggcctCtgcatatttggcccccagaa	12	13	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:49719543C>G	uc001rtx.3	+	5	676	c.509C>G	c.(508-510)TCT>TGT	p.S170C	TROAP_uc009zlh.2_Missense_Mutation_p.S170C|TROAP_uc001rty.2_5'Flank	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	170					cell adhesion	cytoplasm				ovary(1)	1						GTTCGGGCCTCTGCATATTTG	0.622													0	0	0	0.013537	0	12	36										G	49719543	C	G	49719543	3	3	16	1	0	0	0	0	1	0	0	0	16572	913	32	1	625	1	TROAP	12	49719543	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	996172	49719543	84132352	444	4167										
LIMA1	51474	broad.mit.edu	37	chr12	50571638	50571638	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacacccaccttagcaatagGggcatcttctacccctgggc	9	15	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:50571638G>A	uc001rwj.3	-	11	1663	c.1489C>T	c.(1489-1491)CCT>TCT	p.P497S	LIMA1_uc001rwg.3_Missense_Mutation_p.P195S|LIMA1_uc001rwh.3_Missense_Mutation_p.P336S|LIMA1_uc001rwi.3_Missense_Mutation_p.P338S|LIMA1_uc001rwk.3_Missense_Mutation_p.P498S|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	497					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TTAGCAATAGGGGCATCTTCT	0.522													0	0	0	0.009718	0	45	85										A	50571638	G	A	50571638	3	1	16	1	0	0	0	0	1	0	0	0	8796	1232	43	2	794	2	LIMA1	12	50571638	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	852095	50571638	83280257	445	4168										
SLC11A2	4891	broad.mit.edu	37	chr12	51384657	51384657	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccacatgccctaggtcccggAcataaaccactacaaagtac	6	15	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:51384657A>G	uc001rxe.3	-	15	1593	c.1496T>C	c.(1495-1497)GTC>GCC	p.V499A	SLC11A2_uc001rxd.3_Missense_Mutation_p.V348A|SLC11A2_uc001rxc.3_Missense_Mutation_p.V499A|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Missense_Mutation_p.V112A|SLC11A2_uc010smx.1_Missense_Mutation_p.V495A|SLC11A2_uc001rxh.1_Missense_Mutation_p.V499A|SLC11A2_uc001rxj.1_Missense_Mutation_p.V499A|SLC11A2_uc001rxi.2_Missense_Mutation_p.V499A|SLC11A2_uc001rxk.1_Missense_Mutation_p.V528A|SLC11A2_uc010smy.1_Missense_Mutation_p.V462A	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	499	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						TAGGTCCCGGACATAAACCAC	0.478													0	0	0	0.008871	0	20	38										G	51384657	A	G	51384657	3	3	16	1	0	0	0	0	1	0	0	0	14381	275	10	5	279	5	SLC11A2	12	51384657	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	813019	51384657	82467238	446	4169										
KRT7	3855	broad.mit.edu	37	chr12	52627001	52627001	+	Translation_Start_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agccgcccgctcccgcggatAaaaggcgcggagtgtccccg	14	16	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:52627001A>G	uc001saa.1	+	1	48	c.-79A>G	c.(-81--77)ATAAA>ATGAA		KRT7_uc009zmf.1_Translation_Start_Site	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7						cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCCCGCGGATAAAAGGCGCGG	0.731													0	0	0	0.000602	0	5	2										G	52627001	A	G	52627001	1	3	16	1	0	0	0	0	0	0	0	0	8483	377	13	5		5	KRT7	12	52627001	Translation_Start_Site	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1242344	52627001	81224894	447	4170										
KRT84	3890	broad.mit.edu	37	chr12	52777374	52777374	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcagctcagatgtcactcacTtcttcttgaagccctctagg	8	13	6	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:52777374T>C	uc001sah.1	-	2	803	c.755A>G	c.(754-756)AAG>AGG	p.K252R		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	252	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTCACTCACTTCTTCTTGAA	0.582													0	0	0	0.001168	0	6	30										C	52777374	T	C	52777374	3	2	16	1	0	0	0	0	1	0	0	0	8498	1623	56	5	1079	5	KRT84	12	52777374	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	150373	52777374	81074521	448	4171										
KRT3	3850	broad.mit.edu	37	chr12	53186528	53186528	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtccttaagaagtcgatctcAtctatcaaggcatccacttt	6	11	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:53186528A>G	uc001say.2	-	4	1056	c.990T>C	c.(988-990)GAT>GAC	p.D330D		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	330	Rod.|Coil 1B.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						AGTCGATCTCATCTATCAAGG	0.473													0	0	0	0.01441	0	70	154										G	53186528	A	G	53186528	2	3	16	1	0	0	0	0	0	0	0	1	8466	214	8	5		5	KRT3	12	53186528	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	409154	53186528	80665367	449	4172										
CALCOCO1	57658	broad.mit.edu	37	chr12	54115352	54115352	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggtctccctgttgccggctCaggatgtccctctcttctgt	10	14	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:54115352C>T	uc001sef.2	-	6	801	c.657G>A	c.(655-657)CTG>CTA	p.L219L	CALCOCO1_uc010som.1_Silent_p.L186L|CALCOCO1_uc010son.1_Silent_p.L96L|CALCOCO1_uc001seh.2_Silent_p.L219L|CALCOCO1_uc009znd.2_Silent_p.L219L|CALCOCO1_uc001seg.2_Silent_p.L96L|CALCOCO1_uc010soo.1_Silent_p.L212L	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	219					steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						GTTGCCGGCTCAGGATGTCCC	0.537													0	0	0	0.01441	0	138	260										T	54115352	C	T	54115352	2	4	16	1	0	0	0	0	0	0	0	1	2577	813	29	1		1	CALCOCO1	12	54115352	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	928824	54115352	79736543	450	4173										
HOXC9	3225	broad.mit.edu	37	chr12	54394372	54394372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcgcggactgcggcccagggGagggccgcagctacccggac	18	15	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:54394372G>A	uc001sep.2	+	2	498	c.400G>A	c.(400-402)GAG>AAG	p.E134K	HOXC9_uc001seq.2_Missense_Mutation_p.E134K	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	134					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						CGGCCCAGGGGAGGGCCGCAG	0.781													0	0	0	0.000602	0	4	2										A	54394372	G	A	54394372	3	1	16	1	0	0	0	0	1	0	0	0	7317	1175	41	1	402	1	HOXC9	12	54394372	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	279020	54394372	79457523	451	4174										
HOXC5	3222	broad.mit.edu	37	chr12	54428131	54428131	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggaactcgagaaagaattccActttaaccgctacctcactc	6	13	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:54428131A>T	uc001sew.2	+	2	599	c.524A>T	c.(523-525)CAC>CTC	p.H175L	HOXC5_uc001set.2_RNA|HOXC4_uc001seu.2_Intron	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	175	Homeobox.				regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAAGAATTCCACTTTAACCGC	0.537													0	0	0	0.01441	0	47	76										T	54428131	A	T	54428131	3	4	16	1	0	0	0	0	1	0	0	0	7314	159	6	5	530	5	HOXC5	12	54428131	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	33759	54428131	79423764	452	4175										
OR6C1	390321	broad.mit.edu	37	chr12	55714720	55714720	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagtcacagagttttaccttCtggctgccatgtcctatgac	9	11	2	2	rs149008799		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:55714720C>T	uc010spi.1	+	1	337	c.337C>T	c.(337-339)CTG>TTG	p.L113L		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						GTTTTACCTTCTGGCTGCCAT	0.403													0	0	0	0.008291	0	11	28										T	55714720	C	T	55714720	2	4	16	1	0	0	0	0	0	0	0	1	11190	912	32	1		1	OR6C1	12	55714720	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1286589	55714720	78137175	453	4176										
OR6C65	403282	broad.mit.edu	37	chr12	55794973	55794973	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctcctacacactcatccttAaaacaattctgaagattccc	2	14	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:55794973A>G	uc010spl.1	+	1	661	c.661A>G	c.(661-663)AAA>GAA	p.K221E		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTCATCCTTAAAACAATTCT	0.418													0	0	0	0.004878	0	36	93										G	55794973	A	G	55794973	3	3	16	1	0	0	0	0	1	0	0	0	11195	363	13	5	663	5	OR6C65	12	55794973	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	80253	55794973	78056922	454	4177										
OR6C2	341416	broad.mit.edu	37	chr12	55846108	55846108	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcacctacatgttgagtgtAacagggaacctgactattat	8	9	1	2	rs142313431		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:55846108A>G	uc001sgz.1	+	1	111	c.111A>G	c.(109-111)GTA>GTG	p.V37V		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGTTGAGTGTAACAGGGAACC	0.403													0	0	0	0.010504	0	20	42										G	55846108	A	G	55846108	2	3	16	1	0	0	0	0	0	0	0	1	11191	349	13	5		5	OR6C2	12	55846108	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	51135	55846108	78005787	455	4178										
SUOX	6821	broad.mit.edu	37	chr12	56396035	56396035	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcacagagctgtggtcctCaggctccaacaggcctgcag	12	14	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:56396035C>T	uc001six.2	+	4	356	c.30C>T	c.(28-30)CTC>CTT	p.L10L	SUOX_uc009zoh.2_Silent_p.L10L|SUOX_uc001siy.2_Silent_p.L10L|SUOX_uc001siz.2_Silent_p.L10L|SUOX_uc001sja.2_Silent_p.L10L	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	10						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			CTGTGGTCCTCAGGCTCCAAC	0.547													0	0	0	0.014323	0	21	45										T	56396035	C	T	56396035	2	4	16	1	0	0	0	0	0	0	0	1	15392	813	29	1		1	SUOX	12	56396035	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	549927	56396035	77455860	456	4179										
PPM1H	57460	broad.mit.edu	37	chr12	63195923	63195923	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aacagcgaccaatagtggcaGgaaacaccctcggattcctg	10	12	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:63195923G>A	uc001srk.3	-	3	578	c.429C>T	c.(427-429)TCC>TCT	p.S143S		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	143	PP2C-like.						phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		AATAGTGGCAGGAAACACCCT	0.617													0	0	0	0.009096	0	3	24										A	63195923	G	A	63195923	2	1	16	1	0	0	0	0	0	0	0	1	12341	987	35	2		2	PPM1H	12	63195923	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6799888	63195923	70655972	457	4180										
LGR5	8549	broad.mit.edu	37	chr12	71833861	71833861	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggccccctacttcgggcaccAtggacacctcccggctcggt	11	18	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:71833861A>G	uc001swl.2	+	1	49	c.1A>G	c.(1-3)ATG>GTG	p.M1V	TSPAN8_uc001swk.1_Intron|LGR5_uc001swm.2_Missense_Mutation_p.M1V|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	1						integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TTCGGGCACCATGGACACCTC	0.721													0	0	0	0.007291	0	28	38										G	71833861	A	G	71833861	3	3	16	1	0	0	0	0	1	0	0	0	8757	217	8	5	3	5	LGR5	12	71833861	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	8637938	71833861	62018034	458	4181										
TMEM19	55266	broad.mit.edu	37	chr12	72080580	72080580	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	attatatcaatgactgcaagCacctattatggtaagtctga	7	7	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:72080580C>A	uc001sws.2	+	1	703	c.120C>A	c.(118-120)AGC>AGA	p.S40R	TMEM19_uc001swr.1_Missense_Mutation_p.S26R|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	40						integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		TGACTGCAAGCACCTATTATG	0.318													1	0	0.000274275	0.004482	0.000284165	7	49										A	72080580	C	A	72080580	3	1	16	1	0	0	0	0	1	0	0	0	16110	709	25	4	122	4	TMEM19	12	72080580	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	246719	72080580	61771315	459	4182										
SYT1	6857	broad.mit.edu	37	chr12	79689917	79689917	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gggggcacatctgatccttaCgtgaaagtgtttctgctacc	11	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:79689917C>G	uc001sys.2	+	8	1214	c.543C>G	c.(541-543)TAC>TAG	p.Y181*	SYT1_uc001syt.2_Nonsense_Mutation_p.Y181*|SYT1_uc001syu.2_Nonsense_Mutation_p.Y178*|SYT1_uc001syv.2_Nonsense_Mutation_p.Y181*	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	181	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTGATCCTTACGTGAAAGTGT	0.433													0	0	0	0.010818	0	31	40										G	79689917	C	G	79689917	4	3	16	1	0	0	0	0	0	1	0	0	15462	547	19	4	557	4	SYT1	12	79689917	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7609337	79689917	54161978	460	4183										
PPFIA2	8499	broad.mit.edu	37	chr12	82147869	82147869	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcccgaagggtgtctagaagAcgatccctttcatctagcat	9	11	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:82147869A>G	uc001szo.1	-	3	293	c.132T>C	c.(130-132)CGT>CGC	p.R44R	PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(3)|lung(2)|pancreas(1)	6						TGTCTAGAAGACGATCCCTTT	0.527													0	0	0	0.009096	0	4	25										G	82147869	A	G	82147869	2	3	16	1	0	0	0	0	0	0	0	1	12310	262	10	5		5	PPFIA2	12	82147869	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2457952	82147869	51704026	461	4184										
NTS	4922	broad.mit.edu	37	chr12	86276100	86276112	+	Frame_Shift_Del	DEL	GAGAATAAACCCA	GAGAATAAACCCA	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctgaaacggcagctgtatGagaataaacccagaagaccc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:86276100_86276112delGAGAATAAACCCA	uc001tag.2	+	4	567_579	c.460_472delGAGAATAAACCCA	c.(460-474)GAGAATAAACCCAGAfs	p.E154fs		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	154_158					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						GCAGCTGTATGAGAATAAACCCAGAAGACCCTA	0.31																		10	86	---	---								-	86276112	GAGAATAAACCCA	-	86276100	7	5	16	1	0	1	0	1	0	0	0	0	10709	1291	45	0	474	0	NTS	12	86276100	Frame_Shift_Del	DEL	GAGAATAAACCCA	TCGA-BT-A2LB-01A-11D-A18F-08	4128231	86276100	47575795	462	4185										
CEP290	80184	broad.mit.edu	37	chr12	88482816	88482816	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttaaatgtttaccttttggGctcctttggtatcctttaaa	6	7	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:88482816G>C	uc001tar.2	-	31	4366	c.4022C>G	c.(4021-4023)GCC>GGC	p.A1341G	CEP290_uc001taq.2_Missense_Mutation_p.A401G	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1341	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TACCTTTTGGGCTCCTTTGGT	0.209													0	0	0	0.00499	0	16	29										C	88482816	G	C	88482816	3	2	16	1	0	0	0	0	1	0	0	0	3253	1203	42	4	3513	4	CEP290	12	88482816	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2206716	88482816	45369079	463	4186										
KERA	11081	broad.mit.edu	37	chr12	91449642	91449642	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgttctaaacttcttggcaaTggagaaggtacctcctctag	9	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:91449642T>C	uc001tbl.2	-	2	1036	c.417A>G	c.(415-417)CCA>CCG	p.P139P		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	139	LRR 3.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TTCTTGGCAATGGAGAAGGTA	0.413													0	0	0	0.00333	0	25	84										C	91449642	T	C	91449642	2	2	16	1	0	0	0	0	0	0	0	1	8143	1451	51	5		5	KERA	12	91449642	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	2966826	91449642	42402253	464	4187										
METAP2	10988	broad.mit.edu	37	chr12	95907493	95907493	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggaacccttgccttctgccGcagatggctggatcgcttgg	13	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:95907493G>A	uc001tec.2	+	11	1384	c.1250G>A	c.(1249-1251)CGC>CAC	p.R417H	METAP2_uc010suv.1_Missense_Mutation_p.R394H|METAP2_uc009ztd.2_Missense_Mutation_p.R381H|METAP2_uc001ted.2_Missense_Mutation_p.R416H|METAP2_uc001tef.2_Missense_Mutation_p.R394H|METAP2_uc001tee.2_RNA	NM_006838	NP_006829	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2	417					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0					L-Methionine(DB00134)	GCCTTCTGCCGCAGATGGCTG	0.408													0	0	0	0.009096	0	4	76										A	95907493	G	A	95907493	3	1	16	1	0	0	0	0	1	0	0	0	9487	1087	38	2	1292	2	METAP2	12	95907493	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4457851	95907493	37944402	465	4188										
HAL	3034	broad.mit.edu	37	chr12	96374496	96374496	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccaatggccaagtagtctaGggcctgaaagagggtctcca	13	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:96374496G>C	uc001tem.1	-	17	1654	c.1357C>G	c.(1357-1359)CTA>GTA	p.L453V	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Missense_Mutation_p.L245V|HAL_uc010sux.1_Missense_Mutation_p.L453V	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	453					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	AAGTAGTCTAGGGCCTGAAAG	0.493													0	0	0	0.005443	0	20	72										C	96374496	G	C	96374496	3	2	16	1	0	0	0	0	1	0	0	0	6947	991	35	4	636	4	HAL	12	96374496	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	467003	96374496	37477399	466	4189										
MYBPC1	4604	broad.mit.edu	37	chr12	102036322	102036322	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgacctgcgcggcatgctcaAgcgactcaagcgcatgcgca	12	15	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:102036322A>G	uc001tii.2	+	9	818	c.716A>G	c.(715-717)AAG>AGG	p.K239R	MYBPC1_uc001tif.1_Missense_Mutation_p.K252R|MYBPC1_uc001tig.2_Missense_Mutation_p.K264R|MYBPC1_uc010svq.1_Missense_Mutation_p.K226R|MYBPC1_uc001tih.2_Missense_Mutation_p.K264R|MYBPC1_uc001tij.2_Missense_Mutation_p.K239R|MYBPC1_uc010svr.1_Missense_Mutation_p.K239R|MYBPC1_uc010svs.1_Missense_Mutation_p.K239R|MYBPC1_uc010svt.1_Missense_Mutation_p.K227R|MYBPC1_uc010svu.1_Missense_Mutation_p.K220R|MYBPC1_uc001tik.2_Missense_Mutation_p.K213R	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	239					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GGCATGCTCAAGCGACTCAAG	0.627													0	0	0	0.001855	0	14	26										G	102036322	A	G	102036322	3	3	16	1	0	0	0	0	1	0	0	0	10011	72	3	5	833	5	MYBPC1	12	102036322	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	5661826	102036322	31815573	467	4190										
CHPT1	56994	broad.mit.edu	37	chr12	102107950	102107950	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tattgatgggaaacaagccaGaagaacaaactcttgttccc	8	9	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:102107950G>A	uc001tin.2	+	2	579	c.356G>A	c.(355-357)AGA>AAA	p.R119K	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.R119K	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	119					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						AAACAAGCCAGAAGAACAAAC	0.378													0	0	0	0.01441	0	52	124										A	102107950	G	A	102107950	3	1	16	1	0	0	0	0	1	0	0	0	3370	942	33	1	362	1	CHPT1	12	102107950	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	71628	102107950	31743945	468	4191										
HSP90B1	7184	broad.mit.edu	37	chr12	104336508	104336508	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacattactagcctagaccaGtatgtggaaagaatgaagga	11	6	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:104336508G>A	uc001tkb.1	+	12	1683	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	HSP90B1_uc010swg.1_Silent_p.Q191Q|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	526					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GCCTAGACCAGTATGTGGAAA	0.423													0	0	0	0.006122	0	18	60										A	104336508	G	A	104336508	2	1	16	1	0	0	0	0	0	0	0	1	7403	1020	36	2		2	HSP90B1	12	104336508	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2228558	104336508	29515387	469	4192										
MTERFD3	80298	broad.mit.edu	37	chr12	107371523	107371523	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tactatctgtggtgttaattCaagaaccattggcgtctctc	8	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:107371523C>T	uc001tme.1	-	2	2789	c.970G>A	c.(970-972)GAA>AAA	p.E324K	MTERFD3_uc001tmf.1_Missense_Mutation_p.E324K|MTERFD3_uc001tmg.1_Missense_Mutation_p.E324K|MTERFD3_uc001tmh.1_Missense_Mutation_p.E324K	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						GGTGTTAATTCAAGAACCATT	0.358													0	0	0	0.006999	0	38	106										T	107371523	C	T	107371523	3	4	16	1	0	0	0	0	1	0	0	0	9921	835	29	1	191	1	MTERFD3	12	107371523	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3035015	107371523	26480372	470	4193										
CORO1C	23603	broad.mit.edu	37	chr12	109052672	109052672	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcccctgttcccacattccAgatgataatggcattatcac	5	13	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:109052672A>C	uc001tnj.2	-	5	568	c.472T>G	c.(472-474)TGG>GGG	p.W158G	CORO1C_uc009zva.2_Missense_Mutation_p.W211G|CORO1C_uc010sxf.1_Intron	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	158	WD 2.				actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						CCCACATTCCAGATGATAATG	0.413													0	0	0	0.012319	0	20	61										C	109052672	A	C	109052672	3	2	16	1	0	0	0	0	1	0	0	0	3755	188	7	5	980	5	CORO1C	12	109052672	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1681149	109052672	24799223	471	4194										
UBE3B	89910	broad.mit.edu	37	chr12	109935646	109935646	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgtgattgctgcacagttctCagacaatctgattcggccgt	10	10	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:109935646C>T	uc001top.2	+	10	1340	c.737C>T	c.(736-738)TCA>TTA	p.S246L	UBE3B_uc001toq.2_Missense_Mutation_p.S246L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.S246L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	246					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GCACAGTTCTCAGACAATCTG	0.527													0	0	0	0.010818	0	32	90										T	109935646	C	T	109935646	3	4	16	1	0	0	0	0	1	0	0	0	16877	838	29	1	767	1	UBE3B	12	109935646	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	882974	109935646	23916249	472	4195										
UBE3B	89910	broad.mit.edu	37	chr12	109940962	109940962	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctaccagacctcgctgacaActctcacacagattcggctg	7	15	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:109940962A>G	uc001top.2	+	14	2020	c.1417A>G	c.(1417-1419)ACT>GCT	p.T473A	UBE3B_uc001toq.2_Missense_Mutation_p.T473A|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.T473A	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	473					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CTCGCTGACAACTCTCACACA	0.517													0	0	0	0.013537	0	12	39										G	109940962	A	G	109940962	3	3	16	1	0	0	0	0	1	0	0	0	16877	43	2	5	1463	5	UBE3B	12	109940962	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	5316	109940962	23910933	473	4196										
OAS2	4939	broad.mit.edu	37	chr12	113442824	113442824	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	taactcacttaaaagctacaCctcccaaaaaaacgagcggc	5	13	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:113442824C>A	uc001tuj.2	+	7	1405	c.1265C>A	c.(1264-1266)ACC>AAC	p.T422N	OAS2_uc001tui.1_Missense_Mutation_p.T422N	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	422	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						AAAAGCTACACCTCCCAAAAA	0.488													1	0	1.67942e-08	0.006122	1.77192e-08	19	34										A	113442824	C	A	113442824	3	1	16	1	0	0	0	0	1	0	0	0	10800	507	18	4	1362	4	OAS2	12	113442824	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3501862	113442824	20409071	474	4197										
DNAH10	196385	broad.mit.edu	37	chr12	124311275	124311275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagaccctttggatcaacctGaatgtgcagattctccagga	9	11	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:124311275G>A	uc001uft.3	+	24	3892	c.3867G>A	c.(3865-3867)CTG>CTA	p.L1289L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1289	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGATCAACCTGAATGTGCAGA	0.478													0	0	0	0.004878	0	38	85										A	124311275	G	A	124311275	2	1	16	1	0	0	0	0	0	0	0	1	4598	1277	45	1		1	DNAH10	12	124311275	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	10868451	124311275	9540620	475	4198										
GOLGA3	2802	broad.mit.edu	37	chr12	133351795	133351795	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggagcagggtcttcatgtTgttcttcagctccgacactt	10	11	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:133351795T>G	uc001ukz.1	-	22	4634	c.4075A>C	c.(4075-4077)AAC>CAC	p.N1359H	GOLGA3_uc001ula.1_Missense_Mutation_p.N1359H	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1359	Potential.|Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GTCTTCATGTTGTTCTTCAGC	0.582													0	0	0	0.003163	0	16	50										G	133351795	T	G	133351795	3	3	16	1	0	0	0	0	1	0	0	0	6554	1812	63	5	433	5	GOLGA3	12	133351795	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	9040520	133351795	500100	476	4199										
MPHOSPH8	54737	broad.mit.edu	37	chr13	20220640	20220640	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgatagcgatcagcaaagtGagacaaaagaagatacttcc	9	8	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20220640G>C	uc001umh.2	+	3	436	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	MPHOSPH8_uc001umf.1_Missense_Mutation_p.E143Q|MPHOSPH8_uc001umg.2_Missense_Mutation_p.E143Q|MPHOSPH8_uc001umi.2_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	143					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		TCAGCAAAGTGAGACAAAAGA	0.338													0	0	0	0.001168	0	5	32										C	20220640	G	C	20220640	3	2	16	1	0	0	0	0	1	0	0	0	9727	1291	45	1	437	1	MPHOSPH8	13	20220640	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		20220640	94949238	477	4200			1	13		4	4	554	G		3.507778e-07
MPHOSPH8	54737	broad.mit.edu	37	chr13	20220723	20220723	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agcccagatgatctgaaaaaGaaaaaagcaaaggccgggaa	11	7	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20220723G>A	uc001umh.2	+	3	519	c.510G>A	c.(508-510)AAG>AAA	p.K170K	MPHOSPH8_uc001umf.1_Silent_p.K170K|MPHOSPH8_uc001umg.2_Silent_p.K170K|MPHOSPH8_uc001umi.2_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	170	Lys-rich.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ATCTGAAAAAGAAAAAAGCAA	0.378													0	0	0	0.001984	0	6	33										A	20220723	G	A	20220723	2	1	16	1	0	0	0	0	0	0	0	1	9727	933	33	1		1	MPHOSPH8	13	20220723	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	83	20220723	94949155	478	4201			1	13		4	4	554	G		3.507778e-07
MPHOSPH8	54737	broad.mit.edu	37	chr13	20220818	20220818	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgatttaaggacaaagaaaaGaatttctgaagccaaagaag	9	4	1	5			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20220818G>C	uc001umh.2	+	3	614	c.605G>C	c.(604-606)AGA>ACA	p.R202T	MPHOSPH8_uc001umf.1_Missense_Mutation_p.R202T|MPHOSPH8_uc001umg.2_Missense_Mutation_p.R202T|MPHOSPH8_uc001umi.2_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	202	Lys-rich.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ACAAAGAAAAGAATTTCTGAA	0.279													0	0	0	0.00308	0	8	26										C	20220818	G	C	20220818	3	2	16	1	0	0	0	0	1	0	0	0	9727	942	33	1	615	1	MPHOSPH8	13	20220818	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	95	20220818	94949060	479	4202			1	13		4	4	554	G		3.507778e-07
MPHOSPH8	54737	broad.mit.edu	37	chr13	20221193	20221193	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgaggaggataccgatgtcaGaggcaggaggaaaaagaaga	16	4	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20221193G>C	uc001umh.2	+	3	989	c.980G>C	c.(979-981)AGA>ACA	p.R327T	MPHOSPH8_uc001umf.1_Missense_Mutation_p.R327T|MPHOSPH8_uc001umg.2_Missense_Mutation_p.R327T|MPHOSPH8_uc001umi.2_Missense_Mutation_p.R24T	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	327					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ACCGATGTCAGAGGCAGGAGG	0.512													0	0	0	0.001984	0	5	38										C	20221193	G	C	20221193	3	2	16	1	0	0	0	0	1	0	0	0	9727	942	33	1	990	1	MPHOSPH8	13	20221193	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	375	20221193	94948685	480	4203			1	13		4	4	554	G		3.507778e-07
ZMYM2	7750	broad.mit.edu	37	chr13	20633593	20633593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttttgtgtttttagatgataCttggaggacagaatatgttc	10	3	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20633593C>T	uc001umr.2	+	17	2928	c.2630C>T	c.(2629-2631)ACT>ATT	p.T877I	ZMYM2_uc001ums.2_Missense_Mutation_p.T877I|ZMYM2_uc001umt.2_Missense_Mutation_p.T877I|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_Missense_Mutation_p.T257I|ZMYM2_uc001umw.2_Missense_Mutation_p.T330I	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	877					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		TTAGATGATACTTGGAGGACA	0.338													0	0	0	0.013537	0	12	28										T	20633593	C	T	20633593	3	4	16	1	0	0	0	0	1	0	0	0	17697	565	20	2	2684	2	ZMYM2	13	20633593	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	412400	20633593	94536285	481	4204										
PDX1	3651	broad.mit.edu	37	chr13	28494606	28494606	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccgagccgggcgtcctggagGagcccaaccgcgtccagctg	15	16	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:28494606G>A	uc001urt.2	+	1	439	c.331G>A	c.(331-333)GAG>AAG	p.E111K	uc001urs.1_Intron	NM_000209	NP_000200	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	111					detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0	all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CGTCCTGGAGGAGCCCAACCG	0.701													0	0	0	0.001984	0	6	6										A	28494606	G	A	28494606	3	1	16	1	0	0	0	0	1	0	0	0	11695	1175	41	1	333	1	PDX1	13	28494606	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7861013	28494606	86675272	482	4205										
PDS5B	23047	broad.mit.edu	37	chr13	33327664	33327664	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagtatctgaagcagcatgcAgctgttagtggtaagcatat	12	6	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:33327664A>G	uc010abf.2	+	25	3089	c.2931A>G	c.(2929-2931)GCA>GCG	p.A977A	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	977					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGCAGCATGCAGCTGTTAGTG	0.363													0	0	0	0.004672	0	3	28										G	33327664	A	G	33327664	2	3	16	1	0	0	0	0	0	0	0	1	11692	175	7	5		5	PDS5B	13	33327664	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	4833058	33327664	81842214	483	4206										
KL	9365	broad.mit.edu	37	chr13	33635170	33635170	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaggactgccgcgcctcctgGccaggcagggcgcctgggag	17	14	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:33635170G>A	uc001uus.2	+	4	1962	c.1954G>A	c.(1954-1956)GCC>ACC	p.A652T	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	652	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GCGCCTCCTGGCCAGGCAGGG	0.627													0	0	0	0.013537	0	12	61										A	33635170	G	A	33635170	3	1	16	1	0	0	0	0	1	0	0	0	8331	1203	42	2	1968	2	KL	13	33635170	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	307506	33635170	81534708	484	4207										
FAM48A	55578	broad.mit.edu	37	chr13	37603934	37603934	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gactgttggctgtgagtcatCagatttgatagacttttcca	10	7	2	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:37603934C>T	uc001uwg.2	-	13	1209	c.961G>A	c.(961-963)GAT>AAT	p.D321N	FAM48A_uc010abt.2_Missense_Mutation_p.D322N|FAM48A_uc001uwh.2_Missense_Mutation_p.D322N|FAM48A_uc001uwi.2_Missense_Mutation_p.D321N|FAM48A_uc001uwj.2_Missense_Mutation_p.D322N|FAM48A_uc001uwk.2_Missense_Mutation_p.D321N|FAM48A_uc010tes.1_Intron|FAM48A_uc001uwl.1_Missense_Mutation_p.D321N	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	321					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		TGTGAGTCATCAGATTTGATA	0.348													0	0	0	0.004482	0	8	46										T	37603934	C	T	37603934	3	4	16	1	0	0	0	0	1	0	0	0	5572	826	29	1	1434	1	FAM48A	13	37603934	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3968764	37603934	77565944	485	4208										
FREM2	341640	broad.mit.edu	37	chr13	39262253	39262253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctctcctgatggactgcaaaGctttccaggaactaggcgtg	11	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:39262253G>A	uc001uwv.2	+	1	1081	c.772G>A	c.(772-774)GCT>ACT	p.A258T		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	258	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGACTGCAAAGCTTTCCAGGA	0.642													0	0	0	0.012319	0	19	79										A	39262253	G	A	39262253	3	1	16	1	0	0	0	0	1	0	0	0	6045	971	34	2	774	2	FREM2	13	39262253	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1658319	39262253	75907625	486	4209										
NHLRC3	387921	broad.mit.edu	37	chr13	39621938	39621938	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcacaatccaactagcagatCaagttttgccacatctccta	5	13	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:39621938C>T	uc001uxc.2	+	7	1241	c.919C>T	c.(919-921)CAA>TAA	p.Q307*	NHLRC3_uc001uxd.2_Nonsense_Mutation_p.Q240*|NHLRC3_uc001uxe.2_Nonsense_Mutation_p.Q110*	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	307	NHL 4.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		ACTAGCAGATCAAGTTTTGCC	0.468													0	0	0	0.012319	0	18	43										T	39621938	C	T	39621938	4	4	16	1	0	0	0	0	0	1	0	0	10407	827	29	1	945	1	NHLRC3	13	39621938	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	359685	39621938	75547940	487	4210										
FOXO1	2308	broad.mit.edu	37	chr13	41134387	41134387	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtttgggctgggtgaattcAaactggtgtttggtggcgca	16	5	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:41134387A>G	uc001uxl.3	-	2	1626	c.1241T>C	c.(1240-1242)TTG>TCG	p.L414S	FOXO1_uc010acc.1_Missense_Mutation_p.L229S	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	414					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		GGGTGAATTCAAACTGGTGTT	0.488													0	0	0	0.005443	0	22	93										G	41134387	A	G	41134387	3	3	16	1	0	0	0	0	1	0	0	0	6023	131	5	5	730	5	FOXO1	13	41134387	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1512449	41134387	74035491	488	4211										
KIAA0564	23078	broad.mit.edu	37	chr13	42189117	42189117	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcctgtgctaccaacctgttCcgccagcccaagtgttgccg	10	16	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:42189117C>T	uc001uyj.2	-	38	4785	c.4715G>A	c.(4714-4716)GGA>GAA	p.G1572E		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1572						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		CCAACCTGTTCCGCCAGCCCA	0.577													0	0	0	0.004482	0	9	42										T	42189117	C	T	42189117	3	4	16	1	0	0	0	0	1	0	0	0	8185	855	30	1	1034	1	KIAA0564	13	42189117	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1054730	42189117	72980761	489	4212										
DGKH	160851	broad.mit.edu	37	chr13	42763216	42763216	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaacaactgctgcaggctttGcacacagattcccaggctgc	10	13	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:42763216G>A	uc001uyl.1	+	15	1704	c.1683G>A	c.(1681-1683)TTG>TTA	p.L561L	DGKH_uc010tfh.1_Silent_p.L561L|DGKH_uc001uym.1_Silent_p.L561L|DGKH_uc010tfi.1_Silent_p.L316L|DGKH_uc010tfj.1_Silent_p.L416L|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Silent_p.L416L|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	561					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TGCAGGCTTTGCACACAGATT	0.483													0	0	0	0.006214	0	8	32										A	42763216	G	A	42763216	2	1	16	1	0	0	0	0	0	0	0	1	4470	1310	46	2		2	DGKH	13	42763216	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	574099	42763216	72406662	490	4213										
CPB2	1361	broad.mit.edu	37	chr13	46661885	46661885	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttagggagaaattacctcatAtgttgtagtaagattctgta	9	4	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:46661885A>G	uc001vaw.2	-	2	212	c.145T>C	c.(145-147)TAT>CAT	p.Y49H	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Missense_Mutation_p.Y49H	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	49					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		ATTACCTCATATGTTGTAGTA	0.373													0	0	0	0.01441	0	42	56										G	46661885	A	G	46661885	3	3	16	1	0	0	0	0	1	0	0	0	3797	449	16	5	1166	5	CPB2	13	46661885	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3898669	46661885	68507993	491	4214										
SETDB2	83852	broad.mit.edu	37	chr13	50050956	50050956	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctttcaatacctatgttcAgttggctcggaattacccaa	6	10	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:50050956A>T	uc001vcz.2	+	7	1592	c.686A>T	c.(685-687)CAG>CTG	p.Q229L	SETDB2_uc010adg.2_Missense_Mutation_p.Q205L|SETDB2_uc001vcy.3_Missense_Mutation_p.Q217L|SETDB2_uc010adh.2_Missense_Mutation_p.Q217L|SETDB2_uc001vda.2_Missense_Mutation_p.Q217L	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	229	MBD.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		ACCTATGTTCAGTTGGCTCGG	0.378													0	0	0	0.013726	0	34	49										T	50050956	A	T	50050956	3	4	16	1	0	0	0	0	1	0	0	0	14139	188	7	5	708	5	SETDB2	13	50050956	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3389071	50050956	65118922	492	4215										
CKAP2	26586	broad.mit.edu	37	chr13	53035696	53035696	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actaaatttgtgagcactacAtctcagaacacacaacttgt	5	10	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:53035696A>G	uc001vgv.2	+	4	935	c.738A>G	c.(736-738)ACA>ACG	p.T246T	CKAP2_uc001vgt.2_Silent_p.T245T|CKAP2_uc001vgu.2_Silent_p.T245T|CKAP2_uc010tha.1_Silent_p.T197T	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	246					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		TGAGCACTACATCTCAGAACA	0.423													0	0	0	0.010729	0	9	30										G	53035696	A	G	53035696	2	3	16	1	0	0	0	0	0	0	0	1	3442	204	8	5		5	CKAP2	13	53035696	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2984740	53035696	62134182	493	4216										
MYCBP2	23077	broad.mit.edu	37	chr13	77669735	77669735	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggttttctcctagattgtttGacctggcgaagaaaaaaatc	9	7	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:77669735G>A	uc001vkf.2	-	59	9934	c.9843C>T	c.(9841-9843)GTC>GTT	p.V3281V	MYCBP2_uc010aev.2_Silent_p.V2685V|MYCBP2_uc001vke.2_5'Flank	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TAGATTGTTTGACCTGGCGAA	0.373													0	0	0	0.004656	0	24	33										A	77669735	G	A	77669735	2	1	16	1	0	0	0	0	0	0	0	1	10018	1277	45	1		1	MYCBP2	13	77669735	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	24634039	77669735	37500143	494	4217										
MYCBP2	23077	broad.mit.edu	37	chr13	77852999	77852999	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agggatggatgagaaaatcgTgtctctttgatcaattcaaa	10	5	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:77852999T>C	uc001vkf.2	-	5	619	c.528A>G	c.(526-528)ACA>ACG	p.T176T	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GAGAAAATCGTGTCTCTTTGA	0.438													0	0	0	0.006122	0	16	29										C	77852999	T	C	77852999	2	2	16	1	0	0	0	0	0	0	0	1	10018	1683	59	5		5	MYCBP2	13	77852999	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	183264	77852999	37316879	495	4218										
RAP2A	5911	broad.mit.edu	37	chr13	98086808	98086808	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagttcgtgaccggcaccttCatcgagaaatacgaccccac	8	15	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:98086808C>T	uc001vnd.2	+	1	334	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	28					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			CCGGCACCTTCATCGAGAAAT	0.597													0	0	0	0.013726	0	33	105										T	98086808	C	T	98086808	2	4	16	1	0	0	0	0	0	0	0	1	13040	825	29	1		1	RAP2A	13	98086808	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	20233809	98086808	17083070	496	4219										
FARP1	10160	broad.mit.edu	37	chr13	99083317	99083317	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacctggcggctcacctgtgGaagcacagcgaggccttgga	14	13	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:99083317G>A	uc001vnj.2	+	18	2262	c.1926G>A	c.(1924-1926)TGG>TGA	p.W642*	FARP1_uc001vnh.2_Nonsense_Mutation_p.W642*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	642	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CTCACCTGTGGAAGCACAGCG	0.577													0	0	0	0.010729	0	11	46										A	99083317	G	A	99083317	4	1	16	1	0	0	0	0	0	1	0	0	5676	1183	41	1	2215	1	FARP1	13	99083317	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	996509	99083317	16086561	497	4220										
CUL4A	8451	broad.mit.edu	37	chr13	113893835	113893835	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgaggggcgggcagcaggcGctgctgcagcactggagcga	20	10	0	1	rs138821614	byFrequency	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:113893835G>T	uc010tjy.1	+	11	1016	c.1005G>T	c.(1003-1005)GCG>GCT	p.A335A	CUL4A_uc010tjx.1_Silent_p.A235A|CUL4A_uc010agu.2_Silent_p.A196A|CUL4A_uc010tjz.1_Silent_p.A14A	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	335					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GGCAGCAGGCGCTGCTGCAGC	0.637													1	0	1.96895e-08	0.00278	2.07232e-08	20	74										T	113893835	G	T	113893835	2	4	16	1	0	0	0	0	0	0	0	1	4057	1074	38	4		4	CUL4A	13	113893835	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	14810518	113893835	1276043	498	4221										
POTEG	404785	broad.mit.edu	37	chr14	19566047	19566047	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctgactacaaagaaaaacAgatgctaaaagtctcttctg	6	8	3	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:19566047A>G	uc001vuz.1	+	6	1143	c.1091A>G	c.(1090-1092)CAG>CGG	p.Q364R	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_Intron	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	364										ovary(1)	1						AAAGAAAAACAGATGCTAAAA	0.229													0	0	0	0.013537	0	10	135										G	19566047	A	G	19566047	3	3	16	1	0	0	0	0	1	0	0	0	12266	188	7	5	1113	5	POTEG	14	19566047	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08		19566047	87783493	499	4222										
TEP1	7011	broad.mit.edu	37	chr14	20871547	20871547	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gggactcacctttctctgctCttctctgagaaaccctatgt	7	13	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:20871547C>G	uc001vxe.2	-	7	1295	c.1255G>C	c.(1255-1257)GAG>CAG	p.E419Q	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.E311Q	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	419	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TTTCTCTGCTCTTCTCTGAGA	0.408													0	0	0	0.01441	0	65	97										G	20871547	C	G	20871547	3	3	16	1	0	0	0	0	1	0	0	0	15756	922	32	1	6824	1	TEP1	14	20871547	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1305500	20871547	86477993	500	4223										
JUB	84962	broad.mit.edu	37	chr14	23451348	23451348	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggggccctgacttcctaggtCcccccaacccacttaggcgc	10	18	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:23451348C>T	uc001whz.2	-	1	504	c.128G>A	c.(127-129)GGA>GAA	p.G43E		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	43	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTTCCTAGGTCCCCCCAACCC	0.677													0	0	0	0.010729	0	11	42										T	23451348	C	T	23451348	3	4	16	1	0	0	0	0	1	0	0	0	7968	855	30	1	1520	1	JUB	14	23451348	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2579801	23451348	83898192	501	4224										
DHRS4L2	317749	broad.mit.edu	37	chr14	24470602	24470602	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctttctccagggcttcagtCcttacaatgtcagtaaaaca	6	11	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:24470602C>T	uc001wli.3	+	6	671	c.541C>T	c.(541-543)CCT>TCT	p.P181S	DHRS4_uc001wlc.3_Intron|DHRS4L2_uc001wld.3_Intron|DHRS4L2_uc001wle.3_Intron|DHRS4L2_uc001wlg.3_Intron|DHRS4L2_uc001wlh.3_Intron|DHRS4L2_uc010tnt.1_Missense_Mutation_p.P104S|DHRS4L2_uc010alb.2_Missense_Mutation_p.P55S	NM_198083	NP_932349	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4	119							binding|oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)		GGGCTTCAGTCCTTACAATGT	0.478													0	0	0	0.009535	0	25	88										T	24470602	C	T	24470602	3	4	16	1	0	0	0	0	1	0	0	0	4494	855	30	1	563	1	DHRS4L2	14	24470602	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1019254	24470602	82878938	502	4225										
NRL	4901	broad.mit.edu	37	chr14	24551781	24551781	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagcagctccatggcctcttCaggactcagccccaatgcct	8	17	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:24551781C>T	uc001wlo.2	-	2	408	c.277G>A	c.(277-279)GAA>AAA	p.E93K	NRL_uc001wlp.2_Missense_Mutation_p.E93K|NRL_uc001wlq.2_Missense_Mutation_p.E93K	NM_006177	NP_006168	P54845	NRL_HUMAN	neural retina leucine zipper	93					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding				0				GBM - Glioblastoma multiforme(265;0.0181)		ATGGCCTCTTCAGGACTCAGC	0.682													0	0	0	0.010729	0	12	37										T	24551781	C	T	24551781	3	4	16	1	0	0	0	0	1	0	0	0	10656	835	29	1	444	1	NRL	14	24551781	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	81179	24551781	82797759	503	4226										
LTB4R2	56413	broad.mit.edu	37	chr14	24780363	24780363	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctaccgccacctgtggaggGaccgcgtatgccagctgtgc	13	14	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:24780363G>A	uc001woq.1	+	1	2203	c.586G>A	c.(586-588)GAC>AAC	p.D196N	CIDEB_uc001woo.2_5'UTR|CIDEB_uc001wop.2_5'UTR|LTB4R2_uc010alo.2_Missense_Mutation_p.D165N|LTB4R2_uc001wor.2_Missense_Mutation_p.D165N|LTB4R_uc001wos.2_5'Flank|LTB4R_uc010alp.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	196	Extracellular (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		CCTGTGGAGGGACCGCGTATG	0.731													0	0	0	0.001984	0	6	15										A	24780363	G	A	24780363	3	1	16	1	0	0	0	0	1	0	0	0	9072	1174	41	1	495	1	LTB4R2	14	24780363	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	228582	24780363	82569177	504	4227										
PRKD1	5587	broad.mit.edu	37	chr14	30046445	30046445	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agattataggagatggaactCagaggatgctgacacgctca	12	7	2	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:30046445C>T	uc001wqh.2	-	18	2919	c.2738G>A	c.(2737-2739)TGA>TAA	p.*913*		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	913					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AGATGGAACTCAGAGGATGCT	0.443													0	0	0	0.010504	0	19	46										T	30046445	C	T	30046445	2	4	16	1	0	0	0	0	0	0	0	1	12518	837	29	1		1	PRKD1	14	30046445	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	5266082	30046445	77303095	505	4228										
STRN3	29966	broad.mit.edu	37	chr14	31416386	31416386	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctactgatccatttggttctGaattagatagtccaagtaat	7	7	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:31416386G>A	uc001wqu.2	-	5	842	c.626C>T	c.(625-627)TCA>TTA	p.S209L	STRN3_uc001wqv.2_Missense_Mutation_p.S209L|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	209					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		ATTTGGTTCTGAATTAGATAG	0.348													0	0	0	0.005443	0	25	62										A	31416386	G	A	31416386	3	1	16	1	0	0	0	0	1	0	0	0	15329	1294	45	1	1823	1	STRN3	14	31416386	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1369941	31416386	75933154	506	4229										
NKX2-8	26257	broad.mit.edu	37	chr14	37050400	37050400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctccgccgcccctggagcgcGagcgcgcttcagcttgtagc	13	17	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:37050400G>A	uc001wtx.2	-	2	619	c.427C>T	c.(427-429)CGC>TGC	p.R143C		NM_014360	NP_055175	O15522	NKX28_HUMAN	NK2 homeobox 8	143	Homeobox.				liver development|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Breast(36;0.143)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.0113)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0171)		CCTGGAGCGCGAGCGCGCTTC	0.701													0	0	0	0.000602	0	4	6										A	37050400	G	A	37050400	3	1	16	1	0	0	0	0	1	0	0	0	10454	1058	37	1	296	1	NKX2-8	14	37050400	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5634014	37050400	70299140	507	4230										
MIPOL1	145282	broad.mit.edu	37	chr14	37739687	37739687	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctaaagtttaagctggaactCcaagagaaagaaacagaagc	9	7	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:37739687C>T	uc001wuc.2	+	7	953	c.450C>T	c.(448-450)CTC>CTT	p.L150L	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Silent_p.L119L|MIPOL1_uc001wud.2_Silent_p.L150L|MIPOL1_uc010ams.2_Silent_p.L150L|MIPOL1_uc001wue.2_Silent_p.L119L|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	150	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AGCTGGAACTCCAAGAGAAAG	0.333													0	0	0	0.004482	0	8	15										T	37739687	C	T	37739687	2	4	16	1	0	0	0	0	0	0	0	1	9593	842	30	1		1	MIPOL1	14	37739687	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	689287	37739687	69609853	508	4231										
FOXA1	3169	broad.mit.edu	37	chr14	38061866	38061866	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgtaggtgttcatggagttCatggagcccaggcctgagtt	14	7	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:38061866C>T	uc001wuf.2	-	2	435	c.123G>A	c.(121-123)ATG>ATA	p.M41I	FOXA1_uc010tpz.1_Missense_Mutation_p.M8I	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	41					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TCATGGAGTTCATGGAGCCCA	0.597													0	0	0	0.006214	0	9	60										T	38061866	C	T	38061866	3	4	16	1	0	0	0	0	1	0	0	0	5989	826	29	1	1299	1	FOXA1	14	38061866	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	322179	38061866	69287674	509	4232										
LRFN5	145581	broad.mit.edu	37	chr14	42356687	42356687	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagagtttttgtgtgagcctCctctcattactcgtcataca	7	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:42356687C>T	uc001wvm.2	+	3	2057	c.859C>T	c.(859-861)CCT>TCT	p.P287S	LRFN5_uc010ana.2_Missense_Mutation_p.P287S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	287	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTGTGAGCCTCCTCTCATTAC	0.493										HNSCC(30;0.082)			0	0	0	0.003163	0	16	56										T	42356687	C	T	42356687	3	4	16	1	0	0	0	0	1	0	0	0	8941	855	30	1	861	1	LRFN5	14	42356687	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4294821	42356687	64992853	510	4233										
KLHL28	54813	broad.mit.edu	37	chr14	45414370	45414370	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggtactttagggcttcattCaaaagatgtttacaagtgcg	10	6	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:45414370C>T	uc001wvq.2	-	2	1008	c.762G>A	c.(760-762)TTG>TTA	p.L254L	KLHL28_uc001wvr.2_Silent_p.L254L|KLHL28_uc001wvt.3_Silent_p.L254L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	254										ovary(1)	1						GGGCTTCATTCAAAAGATGTT	0.398													0	0	0	0.001168	0	6	30										T	45414370	C	T	45414370	2	4	16	1	0	0	0	0	0	0	0	1	8382	825	29	1		1	KLHL28	14	45414370	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3057683	45414370	61935170	511	4234										
C14orf183	196913	broad.mit.edu	37	chr14	50559295	50559295	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacaggaactcacatttccaTccagatttcaagttgacgtt	6	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:50559295T>C	uc010tqk.1	-	1	67	c.67A>G	c.(67-69)ATG>GTG	p.M23V		NM_001014830	NP_001014830	Q8WXQ3	CN183_HUMAN	hypothetical protein LOC196913	23											0						CACATTTCCATCCAGATTTCA	0.418													0	0	0	0.013537	0	11	28										C	50559295	T	C	50559295	3	2	16	1	0	0	0	0	1	0	0	0	1766	1435	50	5	926	5	C14orf183	14	50559295	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	5144925	50559295	56790245	512	4235										
ARID4A	5926	broad.mit.edu	37	chr14	58820410	58820410	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcaaatgtgactctgaaggaGaggaagatgaggaagacatg	15	4	1	6			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:58820410G>A	uc001xdp.2	+	17	1944	c.1690G>A	c.(1690-1692)GAG>AAG	p.E564K	ARID4A_uc001xdo.2_Missense_Mutation_p.E564K|ARID4A_uc001xdq.2_Missense_Mutation_p.E564K|ARID4A_uc010apg.1_Missense_Mutation_p.E242K	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	564					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CTCTGAAGGAGAGGAAGATGA	0.358													0	0	0	0.010729	0	11	16										A	58820410	G	A	58820410	3	1	16	1	0	0	0	0	1	0	0	0	919	943	33	1	1752	1	ARID4A	14	58820410	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	8261115	58820410	48529130	513	4236										
C14orf39	317761	broad.mit.edu	37	chr14	60945040	60945040	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtctttttcaacagttccttGataaacagtaaattggtcct	6	8	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:60945040G>A	uc001xez.3	-	5	411	c.301C>T	c.(301-303)CAA>TAA	p.Q101*	C14orf39_uc010apo.2_Intron	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	101										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		ACAGTTCCTTGATAAACAGTA	0.289													0	0	0	0.003163	0	12	27										A	60945040	G	A	60945040	4	1	16	1	0	0	0	0	0	1	0	0	1772	1299	45	1	1518	1	C14orf39	14	60945040	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2124630	60945040	46404500	514	4237										
HSPA2	3306	broad.mit.edu	37	chr14	65008648	65008648	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggatttcttcaacggcaagGagctgaacaagagcatcaac	10	9	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:65008648G>C	uc001xhj.2	+	2	1157	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q	HSPA2_uc001xhk.3_Missense_Mutation_p.E361Q	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	361					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CAACGGCAAGGAGCTGAACAA	0.602													0	0	0	0.003163	0	15	42										C	65008648	G	C	65008648	3	2	16	1	0	0	0	0	1	0	0	0	7411	1175	41	1	1083	1	HSPA2	14	65008648	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4063608	65008648	42340892	515	4238										
MPP5	64398	broad.mit.edu	37	chr14	67768707	67768707	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggcacttttactggcccacGataaggttgctgagcaggaa	12	9	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:67768707G>A	uc001xjc.2	+	6	1139	c.673G>A	c.(673-675)GAT>AAT	p.D225N	MPP5_uc001xjd.2_Missense_Mutation_p.D191N|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	225	Interaction with LIN7C (By similarity).|L27 2.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		ACTGGCCCACGATAAGGTTGC	0.383													0	0	0	0.00245	0	14	31										A	67768707	G	A	67768707	3	1	16	1	0	0	0	0	1	0	0	0	9737	1058	37	1	687	1	MPP5	14	67768707	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2760059	67768707	39580833	516	4239										
SLC8A3	6547	broad.mit.edu	37	chr14	70513028	70513028	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctggagggcagcagctttgCtggcaaacgtatctggaaaa	13	9	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:70513028C>G	uc001xly.2	-	8	3174	c.2420G>C	c.(2419-2421)AGC>ACC	p.S807T	SLC8A3_uc001xlu.2_Missense_Mutation_p.S164T|SLC8A3_uc001xlv.2_Missense_Mutation_p.S178T|SLC8A3_uc001xlw.2_Missense_Mutation_p.S804T|SLC8A3_uc001xlx.2_Missense_Mutation_p.S805T|SLC8A3_uc001xlz.2_Missense_Mutation_p.S801T|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_3'UTR	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	807	Alpha-2.|Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGCAGCTTTGCTGGCAAACGT	0.557											OREG0022773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	20										G	70513028	C	G	70513028	3	3	16	1	0	0	0	0	1	0	0	0	14708	797	28	4	367	4	SLC8A3	14	70513028	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2744321	70513028	36836512	517	4240										
SLC8A3	6547	broad.mit.edu	37	chr14	70634195	70634195	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccttgagaatccggatcatCtctctgcgggactcatccac	8	14	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:70634195C>T	uc001xly.2	-	2	1699	c.945G>A	c.(943-945)GAG>GAA	p.E315E	SLC8A3_uc001xlw.2_Silent_p.E315E|SLC8A3_uc001xlx.2_Silent_p.E315E|SLC8A3_uc001xlz.2_Silent_p.E315E|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	315	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCCGGATCATCTCTCTGCGGG	0.483													0	0	0	0.003163	0	14	44										T	70634195	C	T	70634195	2	4	16	1	0	0	0	0	0	0	0	1	14708	912	32	1		1	SLC8A3	14	70634195	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	121167	70634195	36715345	518	4241										
TTC9	23508	broad.mit.edu	37	chr14	71134362	71134362	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttgaagaaggaaggggagaActtcaaggccctttaccggt	13	8	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:71134362A>C	uc001xmi.2	+	2	831	c.488A>C	c.(487-489)AAC>ACC	p.N163T		NM_015351	NP_056166	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	163	TPR 3.						binding				0				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		GAAGGGGAGAACTTCAAGGCC	0.507													0	0	0	0.004007	0	17	48										C	71134362	A	C	71134362	3	2	16	1	0	0	0	0	1	0	0	0	16712	43	2	5	494	5	TTC9	14	71134362	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	500167	71134362	36215178	519	4242										
TC2N	123036	broad.mit.edu	37	chr14	92258883	92258883	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtttaatagcaaatacaaacGtttccataaattcaatagcc	4	8	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:92258883G>A	uc001xzu.3	-	9	1066	c.875C>T	c.(874-876)ACG>ATG	p.T292M	TC2N_uc001xzt.3_Missense_Mutation_p.T292M|TC2N_uc010auc.2_Intron|TC2N_uc001xzv.3_Missense_Mutation_p.T292M	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	292						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		AAATACAAACGTTTCCATAAA	0.254													0	0	0	0.001984	0	6	24										A	92258883	G	A	92258883	3	1	16	1	0	0	0	0	1	0	0	0	15662	1145	40	2	613	2	TC2N	14	92258883	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	21124521	92258883	15090657	520	4243										
TRIP11	9321	broad.mit.edu	37	chr14	92466417	92466417	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttctcctgcattgatttaacTgcatttaaaagctgatttaa	5	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:92466417T>A	uc001xzy.2	-	12	5381	c.4593A>T	c.(4591-4593)GCA>GCT	p.A1531A	TRIP11_uc010auf.1_Silent_p.A1267A	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1531	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTGATTTAACTGCATTTAAAA	0.353			T	PDGFRB	AML								0	0	0	0.00308	0	7	25										A	92466417	T	A	92466417	2	1	16	1	0	0	0	0	0	0	0	1	16552	1567	55	5		5	TRIP11	14	92466417	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	207534	92466417	14883123	521	4244										
GOLGA5	9950	broad.mit.edu	37	chr14	93299524	93299524	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agttagaaaatcgactccatCagctaacagagactctcatc	6	11	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:93299524C>A	uc001yaz.1	+	10	1959	c.1777C>A	c.(1777-1779)CAG>AAG	p.Q593K	GOLGA5_uc001yba.1_5'UTR	NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	593	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		TCGACTCCATCAGCTAACAGA	0.413			T	RET	papillary thyroid								1	0	3.62473e-10	0.012319	3.8622e-10	22	50										A	93299524	C	A	93299524	3	1	16	1	0	0	0	0	1	0	0	0	6556	827	29	3	1811	3	GOLGA5	14	93299524	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	833107	93299524	14050016	522	4245										
DYNC1H1	1778	broad.mit.edu	37	chr14	102446773	102446773	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtttttggctaaacttggaaCgtgcgttataccgcatccag	10	9	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:102446773C>A	uc001yks.2	+	5	1011	c.847C>A	c.(847-849)CGT>AGT	p.R283S		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	283	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AAACTTGGAACGTGCGTTATA	0.468													1	0	0.00024832	0.009096	0.000257894	4	35										A	102446773	C	A	102446773	3	1	16	1	0	0	0	0	1	0	0	0	4841	536	19	4	865	4	DYNC1H1	14	102446773	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	9147249	102446773	4902767	523	4246										
ZNF839	55778	broad.mit.edu	37	chr14	102805205	102805205	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acggaagaaagaaatacaccCagacaaccttggacccaagc	8	12	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:102805205C>G	uc001ylo.2	+	6	1714	c.1364C>G	c.(1363-1365)CCA>CGA	p.P455R	ZNF839_uc010awk.1_Missense_Mutation_p.P571R|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Missense_Mutation_p.P455R|ZNF839_uc001ylr.2_Missense_Mutation_p.P380R|ZNF839_uc001yls.2_Missense_Mutation_p.P70R|ZNF839_uc001ylt.2_Missense_Mutation_p.P45R	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	455						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAAATACACCCAGACAACCTT	0.502													0	0	0	0.001168	0	5	31										G	102805205	C	G	102805205	3	3	16	1	0	0	0	0	1	0	0	0	18185	594	21	4	1734	4	ZNF839	14	102805205	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	358432	102805205	4544335	524	4247										
TRMT61A	115708	broad.mit.edu	37	chr14	103996324	103996324	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacattagcaccatgagcttCgtggcatacgaggagctgat	12	9	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:103996324C>G	uc001yng.2	+	2	128	c.9C>G	c.(7-9)TTC>TTG	p.F3L	TRMT61A_uc010aws.2_Intron	NM_152307	NP_689520	Q96FX7	TRM61_HUMAN	tRNA(m1A58)-methyltransferase subunit TRM61	3						nucleus	protein binding|tRNA (adenine-N1-)-methyltransferase activity				0						CCATGAGCTTCGTGGCATACG	0.617													0	0	0	0.000602	0	3	12										G	103996324	C	G	103996324	3	3	16	1	0	0	0	0	1	0	0	0	16566	883	31	1	11	1	TRMT61A	14	103996324	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1191119	103996324	3353216	525	4248										
AHNAK2	113146	broad.mit.edu	37	chr14	105407270	105407270	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agagtgactctcagcttgagAtgttggaactccctctggag	12	9	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:105407270A>G	uc010axc.1	-	7	14638	c.14518T>C	c.(14518-14520)TCT>CCT	p.S4840P	AHNAK2_uc001ypx.2_Missense_Mutation_p.S4740P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4840						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCAGCTTGAGATGTTGGAACT	0.463													0	0	0	0.009096	0	4	13										G	105407270	A	G	105407270	3	3	16	1	0	0	0	0	1	0	0	0	415	333	12	5	2873	5	AHNAK2	14	105407270	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1410946	105407270	1942270	526	4249										
C15orf2	23742	broad.mit.edu	37	chr15	24922847	24922847	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atacattgcagtgcagagcaGaggcacccgggaaagacatc	12	10	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:24922847G>A	uc001ywo.2	+	1	2307	c.1833G>A	c.(1831-1833)CAG>CAA	p.Q611Q		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	611					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTGCAGAGCAGAGGCACCCGG	0.463													0	0	0	0.013537	0	12	49										A	24922847	G	A	24922847	2	1	16	1	0	0	0	0	0	0	0	1	1784	933	33	1		1	C15orf2	15	24922847	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		24922847	77608545	527	4250										
NDNL2	56160	broad.mit.edu	37	chr15	29561649	29561649	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcaccagctcggacactttCagctccagctgcttctggct	9	15	2	0	rs138846663		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:29561649C>T	uc001zco.2	-	1	369	c.261G>A	c.(259-261)CTG>CTA	p.L87L	FAM189A1_uc010azk.1_Intron	NM_138704	NP_619649	Q96MG7	MAGG1_HUMAN	necdin-like 2	87	MAGE.				regulation of growth	cytoplasm|nucleus					0		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CGGACACTTTCAGCTCCAGCT	0.478											OREG0032044	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.013537	0	11	53										T	29561649	C	T	29561649	2	4	16	1	0	0	0	0	0	0	0	1	10248	813	29	1		1	NDNL2	15	29561649	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4638802	29561649	72969743	528	4251										
TRPM1	4308	broad.mit.edu	37	chr15	31360175	31360175	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgtttcagcttgggctgcaTctcaaagttctggaggcctc	11	10	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:31360175T>C	uc001zfm.2	-	4	462	c.334A>G	c.(334-336)ATG>GTG	p.M112V	TRPM1_uc010azy.2_Missense_Mutation_p.M25V|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	112	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTGGGCTGCATCTCAAAGTTC	0.537													0	0	0	0.014323	0	22	81										C	31360175	T	C	31360175	3	2	16	1	0	0	0	0	1	0	0	0	16582	1435	50	5	4573	5	TRPM1	15	31360175	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1798526	31360175	71171217	529	4252										
EIF2AK4	440275	broad.mit.edu	37	chr15	40241433	40241433	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgggctcaggaggagcagcaGaggctgttggaggccaagcg	19	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:40241433G>A	uc001zkm.1	+	4	527	c.477G>A	c.(475-477)CAG>CAA	p.Q159Q	EIF2AK4_uc001zkl.2_Silent_p.Q159Q	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	159					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGGAGCAGCAGAGGCTGTTGG	0.542													0	0	0	0.008291	0	10	33										A	40241433	G	A	40241433	2	1	16	1	0	0	0	0	0	0	0	1	4999	933	33	1		1	EIF2AK4	15	40241433	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	8881258	40241433	62289959	530	4253										
RHOV	171177	broad.mit.edu	37	chr15	41165414	41165414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcgtcaaggctgagcactCaaggtagcagcaggctcgga	14	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41165414C>T	uc001znd.2	-	3	703	c.553G>A	c.(553-555)GAG>AAG	p.E185K		NM_133639	NP_598378	Q96L33	RHOV_HUMAN	ras homolog gene family, member V	185					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCTGAGCACTCAAGGTAGCAG	0.577													0	0	0	0.00632	0	27	71										T	41165414	C	T	41165414	3	4	16	1	0	0	0	0	1	0	0	0	13346	835	29	1	161	1	RHOV	15	41165414	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	923981	41165414	61365978	531	4254										
RHOV	171177	broad.mit.edu	37	chr15	41165937	41165937	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagctccatccaccaggactTgcactgcaggggcggggcgg	16	13	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41165937T>A	uc001znd.2	-	2	362	c.212A>T	c.(211-213)CAA>CTA	p.Q71L		NM_133639	NP_598378	Q96L33	RHOV_HUMAN	ras homolog gene family, member V	71					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CACCAGGACTTGCACTGCAGG	0.697													0	0	0	0.00333	0	23	91										A	41165937	T	A	41165937	3	1	16	1	0	0	0	0	1	0	0	0	13346	1812	63	5	506	5	RHOV	15	41165937	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	523	41165937	61365455	532	4255										
INO80	54617	broad.mit.edu	37	chr15	41337108	41337108	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaataattgcttacctttaaCaaagggcagctgcaaaggtt	8	7	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41337108C>G	uc001zni.2	-	24	3114	c.2901G>C	c.(2899-2901)TTG>TTC	p.L967F	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	967	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TTACCTTTAACAAAGGGCAGC	0.388													0	0	0	0.001984	0	7	29										G	41337108	C	G	41337108	3	3	16	1	0	0	0	0	1	0	0	0	7746	477	17	4	1821	4	INO80	15	41337108	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	171171	41337108	61194284	533	4256										
INO80	54617	broad.mit.edu	37	chr15	41337203	41337203	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctctggtggctctccccttCtggcgctccccaggagcgta	11	16	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41337203C>T	uc001zni.2	-	24	3019	c.2806G>A	c.(2806-2808)GAA>AAA	p.E936K	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	936	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						CTCTCCCCTTCTGGCGCTCCC	0.493													0	0	0	0.00499	0	14	49										T	41337203	C	T	41337203	3	4	16	1	0	0	0	0	1	0	0	0	7746	922	32	1	1916	1	INO80	15	41337203	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	95	41337203	61194189	534	4257										
WDR76	79968	broad.mit.edu	37	chr15	44127283	44127283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttcgggattgtcaccctacGaaaggaagagactgaagaac	11	8	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:44127283G>A	uc001zti.1	+	3	510	c.487G>A	c.(487-489)GAA>AAA	p.E163K		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	163											0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		GTCACCCTACGAAAGGAAGAG	0.353													0	0	0	0.00308	0	8	28										A	44127283	G	A	44127283	3	1	16	1	0	0	0	0	1	0	0	0	17323	1059	37	1	497	1	WDR76	15	44127283	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2790080	44127283	58404109	535	4258										
COPS2	9318	broad.mit.edu	37	chr15	49437268	49437268	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctcggagttactatcttcaGagtattcctgtgttggaaag	11	7	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:49437268G>C	uc001zxf.2	-	2	141	c.62C>G	c.(61-63)TCT>TGT	p.S21C	COPS2_uc001zxh.2_Missense_Mutation_p.S21C|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	21					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ACTATCTTCAGAGTATTCCTG	0.348													0	0	0	0.003163	0	14	41										C	49437268	G	C	49437268	3	2	16	1	0	0	0	0	1	0	0	0	3733	942	33	1	1338	1	COPS2	15	49437268	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5309985	49437268	53094124	536	4259										
USP8	9101	broad.mit.edu	37	chr15	50776527	50776527	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctaaggacaggaacttttaGagaggatacagacgataccg	11	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:50776527G>A	uc001zym.3	+	13	2359	c.1859G>A	c.(1858-1860)AGA>AAA	p.R620K	USP8_uc001zyl.3_Missense_Mutation_p.R620K|USP8_uc001zyn.3_Missense_Mutation_p.R620K|USP8_uc010ufh.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	620					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GGAACTTTTAGAGAGGATACA	0.299													0	0	0	0.010729	0	9	49										A	50776527	G	A	50776527	3	1	16	1	0	0	0	0	1	0	0	0	17086	942	33	1	1901	1	USP8	15	50776527	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1339259	50776527	51754865	537	4260										
DMXL2	23312	broad.mit.edu	37	chr15	51791720	51791720	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagataccaagtctatagatCtaagaagaacccatcttgac	6	9	3	5			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:51791720C>G	uc002abf.2	-	18	3926	c.3701G>C	c.(3700-3702)AGA>ACA	p.R1234T	DMXL2_uc010ufy.1_Missense_Mutation_p.R1234T|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1234						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GTCTATAGATCTAAGAAGAAC	0.428													0	0	0	0.003163	0	16	40										G	51791720	C	G	51791720	3	3	16	1	0	0	0	0	1	0	0	0	4595	913	32	1	5516	1	DMXL2	15	51791720	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1015193	51791720	50739672	538	4261										
DMXL2	23312	broad.mit.edu	37	chr15	51795035	51795035	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgctcttattacttcaactGattctgggagatcaaggggt	10	7	4	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:51795035G>A	uc002abf.2	-	17	3185	c.2960C>T	c.(2959-2961)TCA>TTA	p.S987L	DMXL2_uc010ufy.1_Missense_Mutation_p.S987L|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	987						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TACTTCAACTGATTCTGGGAG	0.418													0	0	0	0.006214	0	9	46										A	51795035	G	A	51795035	3	1	16	1	0	0	0	0	1	0	0	0	4595	1294	45	1	6261	1	DMXL2	15	51795035	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3315	51795035	50736357	539	4262										
RPL4	6124	broad.mit.edu	37	chr15	66792429	66792429	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagaatggtgttccggcgcaTggtctttgcatatgggttta	13	6	1	1	rs139349583		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:66792429T>C	uc002apv.2	-	9	1059	c.1003A>G	c.(1003-1005)ATG>GTG	p.M335V	SNAPC5_uc002apu.1_5'Flank|RPL4_uc010bhr.2_Missense_Mutation_p.M241V|RPL4_uc002apw.2_Missense_Mutation_p.M241V|RPL4_uc002apx.2_Missense_Mutation_p.M241V	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	335					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TTCCGGCGCATGGTCTTTGCA	0.328													0	0	0	0.010729	0	11	31										C	66792429	T	C	66792429	3	2	16	1	0	0	0	0	1	0	0	0	13595	1464	51	5	288	5	RPL4	15	66792429	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	14997394	66792429	35738963	540	4263										
ANP32A	8125	broad.mit.edu	37	chr15	69080146	69080146	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actttggtaagtttgcgattGaggtgaggcctacgttgatt	13	5	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:69080146G>A	uc002arl.2	-	2	338	c.167C>T	c.(166-168)TCA>TTA	p.S56L		NM_006305	NP_006296	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	56	LRR 2.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding				0						GTTTGCGATTGAGGTGAGGCC	0.468													0	0	0	0.013537	0	13	56										A	69080146	G	A	69080146	3	1	16	1	0	0	0	0	1	0	0	0	705	1294	45	1	606	1	ANP32A	15	69080146	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2287717	69080146	33451246	541	4264										
NOX5	79400	broad.mit.edu	37	chr15	69327745	69327745	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcgggccacgtggctggctCaagtcctaccactggaccag	13	14	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:69327745C>T	uc002ars.1	+	6	927	c.907C>T	c.(907-909)CAA>TAA	p.Q303*	NOX5_uc002arp.1_Nonsense_Mutation_p.Q285*|NOX5_uc002arq.1_Nonsense_Mutation_p.Q257*|NOX5_uc010bid.1_Nonsense_Mutation_p.Q268*|NOX5_uc002arr.1_Nonsense_Mutation_p.Q275*|NOX5_uc010bie.1_Nonsense_Mutation_p.Q103*|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	303	Ferric oxidoreductase.|Cytoplasmic (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GTGGCTGGCTCAAGTCCTACC	0.612													0	0	0	0.010729	0	12	34										T	69327745	C	T	69327745	4	4	16	1	0	0	0	0	0	1	0	0	10559	827	29	1	962	1	NOX5	15	69327745	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	247599	69327745	33203647	542	4265										
THAP10	56906	broad.mit.edu	37	chr15	71184460	71184460	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtggtcagagcagatgaccGagcggtcattgcctccgtac	13	11	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:71184460G>C	uc002asv.2	-	1	294	c.152C>G	c.(151-153)TCG>TGG	p.S51W	LRRC49_uc002asu.2_Intron|LRRC49_uc002asw.2_5'Flank|LRRC49_uc002asx.2_5'Flank|LRRC49_uc010ukf.1_5'Flank	NM_020147	NP_064532	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	51	THAP-type.						DNA binding|metal ion binding			ovary(1)|skin(1)	2						GCAGATGACCGAGCGGTCATT	0.637													0	0	0	0.00308	0	6	31										C	71184460	G	C	71184460	3	2	16	1	0	0	0	0	1	0	0	0	15839	1059	37	1	633	1	THAP10	15	71184460	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1856715	71184460	31346932	543	4266										
CYP11A1	1583	broad.mit.edu	37	chr15	74640360	74640360	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agggccacatcttcagggtcGatgacataaaccgactccac	9	13	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:74640360G>A	uc002axt.2	-	2	461	c.306C>T	c.(304-306)ATC>ATT	p.I102I	CYP11A1_uc002axs.2_5'UTR|CYP11A1_uc010bjm.1_Intron|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Silent_p.I102I|CYP11A1_uc010ulj.1_5'UTR|CYP11A1_uc010bjq.2_Silent_p.I102I	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	102					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CTTCAGGGTCGATGACATAAA	0.443													0	0	0	0.008871	0	15	31										A	74640360	G	A	74640360	2	1	16	1	0	0	0	0	0	0	0	1	4144	1048	37	1		1	CYP11A1	15	74640360	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3455900	74640360	27891032	544	4267										
SGK269	79834	broad.mit.edu	37	chr15	77406944	77406944	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	taggtgcagcatctcatagaTgaggatgcctgtctggaact	12	8	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:77406944T>G	uc002bcm.2	-	6	5103	c.4795A>C	c.(4795-4797)ATC>CTC	p.I1599L		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1599	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		ATCTCATAGATGAGGATGCCT	0.547													0	0	0	0.003163	0	16	28										G	77406944	T	G	77406944	3	3	16	1	0	0	0	0	1	0	0	0	14211	1464	51	5	449	5	SGK269	15	77406944	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	2766584	77406944	25124448	545	4268										
C15orf26	161502	broad.mit.edu	37	chr15	81440822	81440822	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttggatctgcccaaaccacCcacagaggacactcgagcca	9	15	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:81440822C>G	uc002bgb.2	+	7	881	c.854C>G	c.(853-855)CCC>CGC	p.P285R		NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	285											0						CCCAAACCACCCACAGAGGAC	0.547													0	0	0	0.008291	0	9	50										G	81440822	C	G	81440822	3	3	16	1	0	0	0	0	1	0	0	0	1787	623	22	4	880	4	C15orf26	15	81440822	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4033878	81440822	21090570	546	4269										
TMC3	342125	broad.mit.edu	37	chr15	81636366	81636366	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acggtgaagagcatgtcaatGatggagagcttcagcatctc	12	8	3	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:81636366G>A	uc002bgo.1	-	14	1539	c.1539C>T	c.(1537-1539)ATC>ATT	p.I513I	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Silent_p.I513I	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	513	Helical; (Potential).					integral to membrane				ovary(1)|liver(1)	2						GCATGTCAATGATGGAGAGCT	0.537													0	0	0	0.004482	0	8	32										A	81636366	G	A	81636366	2	1	16	1	0	0	0	0	0	0	0	1	15983	1280	45	1		1	TMC3	15	81636366	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	195544	81636366	20895026	547	4270										
AP3B2	8120	broad.mit.edu	37	chr15	83357579	83357579	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggtacacatagacaagcttcTtcaccttggggagagcacgt	11	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:83357579T>C	uc010uoh.1	-	4	446	c.269A>G	c.(268-270)AAG>AGG	p.K90R	AP3B2_uc010uoi.1_Missense_Mutation_p.K90R|AP3B2_uc010uoj.1_Intron|AP3B2_uc010uok.1_Missense_Mutation_p.K90R	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	90					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GACAAGCTTCTTCACCTTGGG	0.597													0	0	0	0.009096	0	3	6										C	83357579	T	C	83357579	3	2	16	1	0	0	0	0	1	0	0	0	745	1609	56	5	2995	5	AP3B2	15	83357579	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1721213	83357579	19173813	548	4271										
ALPK3	57538	broad.mit.edu	37	chr15	85402570	85402570	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttcaacattcttagtgactCagtcttgacatgggccaagg	9	9	4	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:85402570C>T	uc002ble.2	+	7	4687	c.4520C>T	c.(4519-4521)TCA>TTA	p.S1507L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1507	Ig-like 2.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTTAGTGACTCAGTCTTGACA	0.572													0	0	0	0.009096	0	4	25										T	85402570	C	T	85402570	3	4	16	1	0	0	0	0	1	0	0	0	546	838	29	1	4546	1	ALPK3	15	85402570	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2044991	85402570	17128822	549	4272										
AKAP13	11214	broad.mit.edu	37	chr15	86087161	86087161	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggccttggagcgaggctatCacaagctgcaccagcttcta	11	12	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:86087161C>T	uc002blv.1	+	5	807	c.637C>T	c.(637-639)CAC>TAC	p.H213Y	AKAP13_uc002blt.1_Missense_Mutation_p.H213Y|AKAP13_uc002blu.1_Missense_Mutation_p.H213Y	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	213					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCGAGGCTATCACAAGCTGCA	0.587													0	0	0	0.00245	0	12	40										T	86087161	C	T	86087161	3	4	16	1	0	0	0	0	1	0	0	0	449	826	29	1	651	1	AKAP13	15	86087161	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	684591	86087161	16444231	550	4273										
FANCI	55215	broad.mit.edu	37	chr15	89848417	89848417	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttcgtataagagtcctgtcAttctgctgcgtgacttgtcc	9	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:89848417A>C	uc010bnp.1	+	29	3220	c.3130A>C	c.(3130-3132)ATT>CTT	p.I1044L	FANCI_uc002bnm.1_Missense_Mutation_p.I984L|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.I805L|FANCI_uc002bnq.1_Missense_Mutation_p.I457L	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1044					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAGTCCTGTCATTCTGCTGCG	0.453								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.005443	0	24	58										C	89848417	A	C	89848417	3	2	16	1	0	0	0	0	1	0	0	0	5669	217	8	5	3240	5	FANCI	15	89848417	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3761256	89848417	12682975	551	4274										
IQGAP1	8826	broad.mit.edu	37	chr15	90976974	90976974	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttttacccagaaactacagaTatctatgatcgaaagaacat	5	8	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:90976974T>C	uc002bpl.1	+	5	515	c.414T>C	c.(412-414)GAT>GAC	p.D138D		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	138	CH.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAACTACAGATATCTATGATC	0.338													0	0	0	0.00333	0	22	62										C	90976974	T	C	90976974	2	2	16	1	0	0	0	0	0	0	0	1	7814	1403	49	5		5	IQGAP1	15	90976974	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1128557	90976974	11554418	552	4275										
LUC7L	55692	broad.mit.edu	37	chr16	239316	239316	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctctcccaggactcctctcTggatgcccgctctctggaga	10	16	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:239316T>C	uc002cgc.1	-	10	1108	c.997A>G	c.(997-999)AGA>GGA	p.R333G	LUC7L_uc002cga.1_3'UTR|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_3'UTR|LUC7L_uc002cgb.1_Missense_Mutation_p.R247G	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	333	Arg/Ser-rich.						metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				GACTCCTCTCTGGATGCCCGC	0.647													0	0	0	0.01441	0	50	30										C	239316	T	C	239316	3	2	16	1	0	0	0	0	1	0	0	0	9082	1588	55	5	122	5	LUC7L	16	239316	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08		239316	90115437	553	4276										
IFT140	9742	broad.mit.edu	37	chr16	1576661	1576661	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagcacggccacgcgggcctCtagctccggctcctgctccg	12	19	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:1576661C>G	uc002cmb.2	-	20	2898	c.2536G>C	c.(2536-2538)GAG>CAG	p.E846Q	IFT140_uc002clz.2_Intron|TMEM204_uc002cmc.2_5'Flank	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	846										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				ACGCGGGCCTCTAGCTCCGGC	0.741													0	0	0	0.001984	0	5	10										G	1576661	C	G	1576661	3	3	16	1	0	0	0	0	1	0	0	0	7556	922	32	1	1900	1	IFT140	16	1576661	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1337345	1576661	88778092	554	4277										
CASKIN1	57524	broad.mit.edu	37	chr16	2236758	2236758	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggacgggaagtagcccaccCggtcattgcccgtccggttg	14	13	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:2236758C>A	uc010bsg.1	-	10	1030	c.998G>T	c.(997-999)CGG>CTG	p.R333L		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	333	SH3.				signal transduction	cytoplasm				skin(2)	2						GTAGCCCACCCGGTCATTGCC	0.677													1	0	6.94344e-10	0.006122	7.3892e-10	19	14										A	2236758	C	A	2236758	3	1	16	1	0	0	0	0	1	0	0	0	2666	652	23	4	3341	4	CASKIN1	16	2236758	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	660097	2236758	88117995	555	4278										
TMEM159	57146	broad.mit.edu	37	chr16	21172532	21172532	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agaggagccccagagtatctCaagggacttgcaggaactgc	13	10	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:21172532C>T	uc002dif.3	+	2	390	c.29C>T	c.(28-30)TCA>TTA	p.S10L	DNAH3_uc010vbe.1_5'Flank|TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Missense_Mutation_p.S10L|TMEM159_uc002dih.3_Missense_Mutation_p.S10L	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	10						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		CAGAGTATCTCAAGGGACTTG	0.438													0	0	0	0.005443	0	24	52										T	21172532	C	T	21172532	3	4	16	1	0	0	0	0	1	0	0	0	16071	838	29	1	31	1	TMEM159	16	21172532	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	18935774	21172532	69182221	556	4279										
ARHGAP17	55114	broad.mit.edu	37	chr16	24963676	24963676	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttcaggcaattcccgtaaaTaggattttaaagcacctgaa	8	8	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:24963676T>C	uc002dnb.2	-	12	1073	c.980A>G	c.(979-981)TAT>TGT	p.Y327C	ARHGAP17_uc002dna.2_Missense_Mutation_p.Y54C|ARHGAP17_uc002dnc.2_Missense_Mutation_p.Y327C|ARHGAP17_uc010vcf.1_Missense_Mutation_p.Y148C|ARHGAP17_uc002dnf.2_Missense_Mutation_p.Y235C	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	327	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TTCCCGTAAATAGGATTTTAA	0.333													0	0	0	0.003163	0	13	24										C	24963676	T	C	24963676	3	2	16	1	0	0	0	0	1	0	0	0	867	1406	49	5	1701	5	ARHGAP17	16	24963676	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	3791144	24963676	65391077	557	4280										
IL4R	3566	broad.mit.edu	37	chr16	27373925	27373925	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcctggacctgctcggagagGagaatgggggcttttgccag	16	9	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:27373925G>A	uc002don.2	+	11	1494	c.1252G>A	c.(1252-1254)GAG>AAG	p.E418K	IL4R_uc002dop.3_Missense_Mutation_p.E403K|IL4R_uc010bxy.2_Missense_Mutation_p.E418K|IL4R_uc002doo.2_Missense_Mutation_p.E258K	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	418	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						GCTCGGAGAGGAGAATGGGGG	0.597													0	0	0	0.010729	0	10	50										A	27373925	G	A	27373925	3	1	16	1	0	0	0	0	1	0	0	0	7698	1175	41	1	1304	1	IL4R	16	27373925	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2410249	27373925	62980828	558	4281										
SULT1A2	6799	broad.mit.edu	37	chr16	28603636	28603636	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgaactcccggcggacggtGgtgtagttggtcatagggtt	16	7	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:28603636G>A	uc002dqg.1	-	7	1074	c.723C>T	c.(721-723)ACC>ACT	p.T241T	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Silent_p.T241T	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	241					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						GGCGGACGGTGGTGTAGTTGG	0.592													0	0	0	0.005443	0	26	121										A	28603636	G	A	28603636	2	1	16	1	0	0	0	0	0	0	0	1	15372	1335	47	2		2	SULT1A2	16	28603636	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1229711	28603636	61751117	559	4282										
PRRT2	112476	broad.mit.edu	37	chr16	29824989	29824989	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgagcctcactcaccaccctCaaaaaaatcccccccagcca	3	20	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:29824989C>T	uc002due.3	+	2	915	c.614C>T	c.(613-615)TCA>TTA	p.S205L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.S205L|PRRT2_uc002duf.1_Missense_Mutation_p.S205L|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	205	Extracellular (Potential).|Pro-rich.				response to biotic stimulus	integral to membrane					0						TCACCACCCTCAAAAAAATCC	0.612													0	0	0	0.00308	0	7	8										T	29824989	C	T	29824989	3	4	16	1	0	0	0	0	1	0	0	0	12610	838	29	1	616	1	PRRT2	16	29824989	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1221353	29824989	60529764	560	4283										
PRSS53	339105	broad.mit.edu	37	chr16	31098143	31098143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcagccacccccacctcttCggccccagggctgagtccct	10	20	1	1	rs138969193	by1000genomes	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:31098143C>T	uc002eaq.2	-	4	319	c.319G>A	c.(319-321)GAA>AAA	p.E107K	PRSS53_uc002ear.2_5'UTR	NM_001039503	NP_001034592	Q2L4Q9	PRS53_HUMAN	polyserase 3 precursor	107	Peptidase S1 1.				proteolysis	extracellular region	serine-type endopeptidase activity				0						CCCACCTCTTCGGCCCCAGGG	0.642													0	0	0	0.008291	0	11	56										T	31098143	C	T	31098143	3	4	16	1	0	0	0	0	1	0	0	0	12632	893	31	1	1374	1	PRSS53	16	31098143	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1273154	31098143	59256610	561	4284										
ITGAM	3684	broad.mit.edu	37	chr16	31341893	31341893	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aacgattccgtgttcaccctGctgccgggacagggggcgtt	14	12	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:31341893G>A	uc002ebq.2	+	28	3341	c.3243G>A	c.(3241-3243)CTG>CTA	p.L1081L	ITGAM_uc002ebr.2_Silent_p.L1082L|ITGAM_uc010can.2_Silent_p.L487L	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	1081	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						TGTTCACCCTGCTGCCGGGAC	0.592													0	0	0	0.00308	0	7	14										A	31341893	G	A	31341893	2	1	16	1	0	0	0	0	0	0	0	1	7887	1306	46	2		2	ITGAM	16	31341893	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	243750	31341893	59012860	562	4285										
ABCC12	94160	broad.mit.edu	37	chr16	48180326	48180326	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgagataaggtagggtccttCacccaccatcctgatggcag	11	11	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:48180326C>T	uc002efc.1	-	1	356	c.10G>A	c.(10-12)GAA>AAA	p.E4K	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.E4K|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	4						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TAGGGTCCTTCACCCACCATC	0.552													0	0	0	0.004482	0	8	55										T	48180326	C	T	48180326	3	4	16	1	0	0	0	0	1	0	0	0	52	835	29	1	4185	1	ABCC12	16	48180326	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	16838433	48180326	42174427	563	4286										
ADCY7	113	broad.mit.edu	37	chr16	50332877	50332877	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tactgtgtatcgggcctgccCgtgtcgctgcctacccacgc	11	16	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:50332877C>T	uc002egd.1	+	7	1279	c.1011C>T	c.(1009-1011)CCC>CCT	p.P337P	ADCY7_uc002egb.1_Silent_p.P337P|ADCY7_uc002egc.1_Silent_p.P337P	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	337	Cytoplasmic (Potential).|Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CGGGCCTGCCCGTGTCGCTGC	0.637													0	0	0	0.00632	0	28	39										T	50332877	C	T	50332877	2	4	16	1	0	0	0	0	0	0	0	1	299	639	23	2		2	ADCY7	16	50332877	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2152551	50332877	40021876	564	4287										
BRD7	29117	broad.mit.edu	37	chr16	50359717	50359717	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgaatagattaaatcagaatCatccttgctgatatttgcaa	6	6	2	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:50359717C>T	uc002egf.1	-	12	1340	c.1273G>A	c.(1273-1275)GAT>AAT	p.D425N	BRD7_uc002ege.1_Missense_Mutation_p.D425N	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	425					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				AAATCAGAATCATCCTTGCTG	0.338													0	0	0	0.00308	0	8	32										T	50359717	C	T	50359717	3	4	16	1	0	0	0	0	1	0	0	0	1505	826	29	1	713	1	BRD7	16	50359717	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	26840	50359717	39995036	565	4288										
CNGB1	1258	broad.mit.edu	37	chr16	57918175	57918175	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caccgagtgctcttcgggctCggccggcccctcctcctctc	10	20	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:57918175C>T	uc002emt.2	-	33	3714	c.3649G>A	c.(3649-3651)GAG>AAG	p.E1217K	CNGB1_uc010cdh.2_Missense_Mutation_p.E1211K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1217	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						TCTTCGGGCTCGGCCGGCCCC	0.726													0	0	0	0.003271	0	34	28										T	57918175	C	T	57918175	3	4	16	1	0	0	0	0	1	0	0	0	3600	893	31	1	110	1	CNGB1	16	57918175	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7558458	57918175	32436578	566	4289										
CTCF	10664	broad.mit.edu	37	chr16	67650746	67650746	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aacacacccacgagaagccaTtcaagtgttccatgtgcgat	8	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:67650746T>C	uc002etl.2	+	5	1341	c.1051T>C	c.(1051-1053)TTC>CTC	p.F351L	CTCF_uc010cek.2_Missense_Mutation_p.F23L	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	351	C2H2-type 4.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CGAGAAGCCATTCAAGTGTTC	0.468													0	0	0	0.013726	0	31	143										C	67650746	T	C	67650746	3	2	16	1	0	0	0	0	1	0	0	0	4000	1493	52	5	1061	5	CTCF	16	67650746	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	9732571	67650746	22704007	567	4290										
CENPT	80152	broad.mit.edu	37	chr16	67865747	67865747	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccaggggccagcagacctgGagccagggttgtggggggct	20	10	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:67865747G>C	uc002eun.3	-	8	982	c.433C>G	c.(433-435)CCA>GCA	p.P145A	CENPT_uc002eum.3_Missense_Mutation_p.P145A|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_Intron|CENPT_uc010vke.1_Missense_Mutation_p.P42A	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	145					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		AGCAGACCTGGAGCCAGGGTT	0.582													0	0	0	0.010729	0	12	31										C	67865747	G	C	67865747	3	2	16	1	0	0	0	0	1	0	0	0	3242	1174	41	1	1288	1	CENPT	16	67865747	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	215001	67865747	22489006	568	4291										
NIP7	51388	broad.mit.edu	37	chr16	69375197	69375197	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctcagtaccagggcgtggtgGtgtactccatggcagacatc	13	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:69375197G>A	uc002exa.2	+	4	584	c.397G>A	c.(397-399)GTG>ATG	p.V133M	COG8_uc002ewy.2_5'Flank|COG8_uc002ewz.3_5'Flank|NIP7_uc002exb.2_Intron	NM_016101	NP_057185	Q9Y221	NIP7_HUMAN	nuclear import 7	133	PUA.				ribosome assembly	nucleolus	protein binding|RNA binding			breast(1)	1		Ovarian(137;0.101)				GGGCGTGGTGGTGTACTCCAT	0.468													0	0	0	0.001855	0	12	23										A	69375197	G	A	69375197	3	1	16	1	0	0	0	0	1	0	0	0	10421	1261	44	2	411	2	NIP7	16	69375197	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1509450	69375197	20979556	569	4292										
TERF2	7014	broad.mit.edu	37	chr16	69419544	69419544	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtccccgtaccggctaccccGaaaggcccgcagcgcctcgt	11	19	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:69419544G>C	uc002exd.2	-	1	330	c.205C>G	c.(205-207)CGG>GGG	p.R69G	TERF2_uc002exe.2_Missense_Mutation_p.R69G	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	69	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				CGGCTACCCCGAAAGGCCCGC	0.582													0	0	0	0.009096	0	3	23										C	69419544	G	C	69419544	3	2	16	1	0	0	0	0	1	0	0	0	15759	1057	37	1	1337	1	TERF2	16	69419544	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	44347	69419544	20935209	570	4293										
USP10	9100	broad.mit.edu	37	chr16	84778354	84778354	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgaaccctcaggcccctgaAtttattctcggttgtacagc	8	13	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:84778354A>G	uc002fii.2	+	4	409	c.267A>G	c.(265-267)GAA>GAG	p.E89E	USP10_uc010voe.1_Silent_p.E93E|USP10_uc010vof.1_Intron|USP10_uc002fij.2_5'UTR	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	89	Interaction with p53/TP53.				DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AGGCCCCTGAATTTATTCTCG	0.493													0	0	0	0.013726	0	31	47										G	84778354	A	G	84778354	2	3	16	1	0	0	0	0	0	0	0	1	17038	98	4	5		5	USP10	16	84778354	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	15358810	84778354	5576399	571	4294										
APRT	353	broad.mit.edu	37	chr16	88877971	88877971	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cactcgcctgcgatgtagtcGatgcggcccccgtgggtcgc	14	15	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:88877971G>A	uc002flv.2	-	2	209	c.174C>T	c.(172-174)ATC>ATT	p.I58I	APRT_uc002flw.2_Silent_p.I58I	NM_000485	NP_000476	P07741	APT_HUMAN	adenine phosphoribosyltransferase isoform a	58					purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	CGATGTAGTCGATGCGGCCCC	0.721													0	0	0	0.001168	0	4	7										A	88877971	G	A	88877971	2	1	16	1	0	0	0	0	0	0	0	1	819	1048	37	1		1	APRT	16	88877971	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4099617	88877971	1476782	572	4295										
MED11	400569	broad.mit.edu	37	chr17	4635097	4635097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgatcctagaattgtccaagGaaaaaactaacgagcggctc	9	9	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:4635097G>A	uc002fyp.2	+	2	174	c.112G>A	c.(112-114)GAA>AAA	p.E38K		NM_001001683	NP_001001683	Q9P086	MED11_HUMAN	mediator complex subunit 11	38					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	protein binding				0						ATTGTCCAAGGAAAAAACTAA	0.617											OREG0024104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	12	18										A	4635097	G	A	4635097	3	1	16	1	0	0	0	0	1	0	0	0	9427	1175	41	1	118	1	MED11	17	4635097	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		4635097	76560113	573	4296										
SLC16A13	201232	broad.mit.edu	37	chr17	6941694	6941694	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtggcctgtggtgctctcctCcgcccaccctccctggctga	11	18	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:6941694C>T	uc002geh.2	+	3	875	c.567C>T	c.(565-567)CTC>CTT	p.L189L		NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13	189	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						GTGCTCTCCTCCGCCCACCCT	0.657													0	0	0	0.012213	0	32	44										T	6941694	C	T	6941694	2	4	16	1	0	0	0	0	0	0	0	1	14406	842	30	1		1	SLC16A13	17	6941694	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2306597	6941694	74253516	574	4297										
SLC2A4	6517	broad.mit.edu	37	chr17	7187317	7187317	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacatcagggctggtgcccaTgtacgtgggggagattgctc	16	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:7187317T>C	uc002gfp.2	+	5	673	c.473T>C	c.(472-474)ATG>ACG	p.M158T	SLC2A4_uc002gfo.2_Missense_Mutation_p.M158T|SLC2A4_uc010cmd.2_RNA	NM_001042	NP_001033	P14672	GTR4_HUMAN	glucose transporter 4	158	Helical; Name=4; (Potential).				carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding				0						CTGGTGCCCATGTACGTGGGG	0.612													0	0	0	0.006214	0	10	14										C	7187317	T	C	7187317	3	2	16	1	0	0	0	0	1	0	0	0	14546	1464	51	5	491	5	SLC2A4	17	7187317	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	245623	7187317	74007893	575	4298										
C17orf74	201243	broad.mit.edu	37	chr17	7329872	7329872	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cggattcctacctggaggagGaggacaacctgcccttcccg	12	14	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:7329872G>T	uc002ggw.2	+	3	635	c.562G>T	c.(562-564)GAG>TAG	p.E188*	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	188						integral to membrane					0		Prostate(122;0.157)				CCTGGAGGAGGAGGACAACCT	0.592													1	0	9.72345e-25	0.01441	1.05429e-24	54	69										T	7329872	G	T	7329872	4	4	16	1	0	0	0	0	0	1	0	0	1879	1175	41	3	572	3	C17orf74	17	7329872	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	142555	7329872	73865338	576	4299										
TP53	7157	broad.mit.edu	37	chr17	7578269	7578269	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atttccttccactcggataaGatgctgaggaggggccagac	12	10	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:7578269G>A	uc002gim.2	-	6	774	c.580C>T	c.(580-582)CTT>TTT	p.L194F	TP53_uc002gig.1_Missense_Mutation_p.L194F|TP53_uc002gih.2_Missense_Mutation_p.L194F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L62F|TP53_uc010cng.1_Missense_Mutation_p.L62F|TP53_uc002gii.1_Missense_Mutation_p.L62F|TP53_uc010cnh.1_Missense_Mutation_p.L194F|TP53_uc010cni.1_Missense_Mutation_p.L194F|TP53_uc002gij.2_Missense_Mutation_p.L194F|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.L101F|TP53_uc002gio.2_Missense_Mutation_p.L62F|TP53_uc010vug.1_Missense_Mutation_p.L155F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191fs*53(2)|p.L194fs*15(2)|p.K164_P219del(1)|p.L194fs*14(1)|p.A189fs*53(1)|p.L194V(1)|p.L194I(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.L194fs*52(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACTCGGATAAGATGCTGAGGA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00245	0	13	18										A	7578269	G	A	7578269	3	1	16	1	0	0	0	0	1	0	0	0	16378	942	33	1	714	1	TP53	17	7578269	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	248397	7578269	73616941	577	4300										
TMEM220	388335	broad.mit.edu	37	chr17	10628432	10628432	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agtatgtgtattgcagagatActtttccaaataacattacc	6	7	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:10628432A>G	uc002gmx.2	-	4	661	c.183T>C	c.(181-183)AGT>AGC	p.S61S	TMEM220_uc002gmy.2_Silent_p.S51S	NM_001004313	NP_001004313	Q6QAJ8	TM220_HUMAN	transmembrane protein 220	61						integral to membrane					0						TTGCAGAGATACTTTTCCAAA	0.388													0	0	0	0.013537	0	12	16										G	10628432	A	G	10628432	2	3	16	1	0	0	0	0	0	0	0	1	16141	388	14	5		5	TMEM220	17	10628432	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3050163	10628432	70566778	578	4301										
SREBF1	6720	broad.mit.edu	37	chr17	17716923	17716923	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agctctgtgccagccgcctcAggctgctcaggtcccgttgg	13	15	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:17716923A>G	uc002gru.1	-	17	3256	c.3062T>C	c.(3061-3063)CTG>CCG	p.L1021P	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Missense_Mutation_p.L640P|SREBF1_uc002grq.1_Missense_Mutation_p.L540P|SREBF1_uc002grr.1_Missense_Mutation_p.L767P|SREBF1_uc002grs.1_Missense_Mutation_p.L997P|SREBF1_uc002grt.1_Missense_Mutation_p.L1051P	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	1021	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CAGCCGCCTCAGGCTGCTCAG	0.711													0	0	0	0.004672	0	2	5										G	17716923	A	G	17716923	3	3	16	1	0	0	0	0	1	0	0	0	15140	188	7	5	393	5	SREBF1	17	17716923	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	7088491	17716923	63478287	579	4302										
ULK2	9706	broad.mit.edu	37	chr17	19705182	19705182	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggtactggggagcatgatCccggccggaggaagcccatg	16	11	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:19705182C>G	uc002gwm.3	-	16	1858	c.1349G>C	c.(1348-1350)GGA>GCA	p.G450A	ULK2_uc002gwn.2_Missense_Mutation_p.G450A	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	450					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GGAGCATGATCCCGGCCGGAG	0.507													0	0	0	0.01441	0	73	83										G	19705182	C	G	19705182	3	3	16	1	0	0	0	0	1	0	0	0	16973	855	30	1	1809	1	ULK2	17	19705182	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1988259	19705182	61490028	580	4303										
MYO18A	399687	broad.mit.edu	37	chr17	27493277	27493277	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggagaagccaaagtctccagTgggccgtcgttgcagctcca	13	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:27493277T>C	uc002hdt.1	-	2	840	c.682A>G	c.(682-684)ACT>GCT	p.T228A	MYO18A_uc010csa.1_Missense_Mutation_p.T228A|MYO18A_uc002hdu.1_Missense_Mutation_p.T228A	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	228	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AAGTCTCCAGTGGGCCGTCGT	0.667													0	0	0	0.013726	0	32	56										C	27493277	T	C	27493277	3	2	16	1	0	0	0	0	1	0	0	0	10065	1696	59	5	5646	5	MYO18A	17	27493277	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	7788095	27493277	53701933	581	4304										
EFCAB5	374786	broad.mit.edu	37	chr17	28384744	28384759	+	Frame_Shift_Del	DEL	AGAACTGCCTTCAATG	AGAACTGCCTTCAATG	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttgcaaggaggtaaaaggcAgaactgccttcaatggagtt							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:28384744_28384759delAGAACTGCCTTCAATG	uc002het.2	+	13	2608_2623	c.2416_2431delAGAACTGCCTTCAATG	c.(2416-2433)AGAACTGCCTTCAATGGAfs	p.R806fs	EFCAB5_uc010wbj.1_Frame_Shift_Del_p.R750fs|EFCAB5_uc010wbk.1_Frame_Shift_Del_p.R463fs|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Intron|EFCAB5_uc010csf.2_Frame_Shift_Del_p.R685fs	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	806_811							calcium ion binding			ovary(1)|skin(1)	2						GGTAAAAGGCAGAACTGCCTTCAATGGAGTTTCATT	0.403																		10	58	---	---								-	28384759	AGAACTGCCTTCAATG	-	28384744	7	5	16	1	0	1	0	1	0	0	0	0	4938	180	7	0	2466	0	EFCAB5	17	28384744	Frame_Shift_Del	DEL	AGAACTGCCTTCAATG	TCGA-BT-A2LB-01A-11D-A18F-08	891467	28384744	52810466	582	4305										
NF1	4763	broad.mit.edu	37	chr17	29679408	29679408	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggacatggggcaaccttctCaggccaacactaagaagttg	11	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:29679408C>T	uc002hgg.2	+	51	7924	c.7591C>T	c.(7591-7593)CAG>TAG	p.Q2531*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q2510*|NF1_uc010cso.2_Nonsense_Mutation_p.Q719*|NF1_uc010wbt.1_Intron|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2531					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCAACCTTCTCAGGCCAACAC	0.388			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.004482	0	8	29										T	29679408	C	T	29679408	4	4	16	1	0	0	0	0	0	1	0	0	10356	827	29	1	7854	1	NF1	17	29679408	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1294664	29679408	51515802	583	4306										
LIG3	3980	broad.mit.edu	37	chr17	33325294	33325294	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atccaggagggattggagggGctggtgctgaaggatgtgaa	19	4	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:33325294G>A	uc002hik.1	+	13	2076	c.1968G>A	c.(1966-1968)GGG>GGA	p.G656G	LIG3_uc002hij.2_Silent_p.G656G	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	656					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	GATTGGAGGGGCTGGTGCTGA	0.562								Other_BER_factors			OREG0024326	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	13	42										A	33325294	G	A	33325294	2	1	16	1	0	0	0	0	0	0	0	1	8782	1190	42	2		2	LIG3	17	33325294	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3645886	33325294	47869916	584	4307										
DHRS11	79154	broad.mit.edu	37	chr17	34956152	34956152	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgccttcaaactccacgacaAggaccctgagaaggcagctg	10	14	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:34956152A>G	uc002hnd.2	+	5	849	c.635A>G	c.(634-636)AAG>AGG	p.K212R	MRM1_uc002hne.2_5'Flank|MRM1_uc002hnf.2_5'Flank	NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	212						extracellular region	binding|oxidoreductase activity				0						CTCCACGACAAGGACCCTGAG	0.572													0	0	0	0.00278	0	22	41										G	34956152	A	G	34956152	3	3	16	1	0	0	0	0	1	0	0	0	4487	72	3	5	653	5	DHRS11	17	34956152	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1630858	34956152	46239058	585	4308										
SOCS7	30837	broad.mit.edu	37	chr17	36551570	36551570	+	Frame_Shift_Del	DEL	C	C	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctttcttgaaggactgccaCcaactcctgtccagctgctc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:36551570delC	uc002hqa.2	+	8	1621	c.1498delC	c.(1498-1500)CCAfs	p.P500fs	SOCS7_uc010cvl.2_Frame_Shift_Del_p.P466fs|SOCS7_uc002hqb.2_Intron	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	500	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					AGGACTGCCACCAACTCCTGT	0.468																		13	31	---	---								-	36551570	C	-	36551570	7	5	16	1	0	1	0	1	0	0	0	0	14919	507	18	0	1528	0	SOCS7	17	36551570	Frame_Shift_Del	DEL	C	TCGA-BT-A2LB-01A-11D-A18F-08	1595418	36551570	44643640	586	4309										
RARA	5914	broad.mit.edu	37	chr17	38510642	38510642	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaaccggacccagatgcacaAcgctggcttcggccccctca	10	17	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:38510642A>G	uc002huk.1	+	7	1351	c.896A>G	c.(895-897)AAC>AGC	p.N299S	RARA_uc002hul.3_Missense_Mutation_p.N299S|RARA_uc010wfe.1_Missense_Mutation_p.N202S|RARA_uc002hun.1_Missense_Mutation_p.N294S	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	299	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CAGATGCACAACGCTGGCTTC	0.652			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								0	0	0	0.003163	0	15	71										G	38510642	A	G	38510642	3	3	16	1	0	0	0	0	1	0	0	0	13052	43	2	5	1085	5	RARA	17	38510642	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1959072	38510642	42684568	587	4310										
KRT33B	3884	broad.mit.edu	37	chr17	39521742	39521742	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacctggttcaggtccacagCgggagcagcgtccacctcca	12	15	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:39521742C>T	uc002hwl.2	-	4	697	c.652G>A	c.(652-654)GCT>ACT	p.A218T		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	218	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				AGGTCCACAGCGGGAGCAGCG	0.562													0	0	0	0.00499	0	16	34										T	39521742	C	T	39521742	3	4	16	1	0	0	0	0	1	0	0	0	8470	768	27	2	578	2	KRT33B	17	39521742	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1011100	39521742	41673468	588	4311										
MEOX1	4222	broad.mit.edu	37	chr17	41719371	41719371	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccttcacacgcttccacttCatccttcggttctggaacca	5	17	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:41719371C>G	uc002idz.2	-	3	701	c.672G>C	c.(670-672)ATG>ATC	p.M224I	MEOX1_uc002iea.2_Missense_Mutation_p.E167Q|MEOX1_uc002ieb.2_Missense_Mutation_p.M109I	NM_004527	NP_004518	P50221	MEOX1_HUMAN	mesenchyme homeobox 1 isoform 1	224	Homeobox.					nucleus	sequence-specific DNA binding				0		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		GCTTCCACTTCATCCTTCGGT	0.582													0	0	0	0.012213	0	28	119										G	41719371	C	G	41719371	3	3	16	1	0	0	0	0	1	0	0	0	9473	835	29	1	96	1	MEOX1	17	41719371	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2197629	41719371	39475839	589	4312										
GRN	2896	broad.mit.edu	37	chr17	42427117	42427117	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcgatcctgcttccaaagatCaggtgcagctggggtgtggg	16	9	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:42427117C>G	uc002igp.1	+	4	566	c.347C>G	c.(346-348)TCA>TGA	p.S116*	GRN_uc002igq.1_3'UTR|GRN_uc002igr.1_5'Flank	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	116					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TTCCAAAGATCAGGTGCAGCT	0.652													0	0	0	0.004672	0	3	20										G	42427117	C	G	42427117	4	3	16	1	0	0	0	0	0	1	0	0	6804	838	29	1	357	1	GRN	17	42427117	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	707746	42427117	38768093	590	4313										
ITGA2B	3674	broad.mit.edu	37	chr17	42462950	42462957	+	Frame_Shift_Del	DEL	GGTGTTCC	GGTGTTCC	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccacgtaaatgcggctcagGgtgttcccgcgacaggggga							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:42462950_42462957delGGTGTTCC	uc002igt.1	-	4	568_575	c.536_543delGGAACACC	c.(535-543)GGGAACACCfs	p.G179fs		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	179_181	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	TGCGGCTCAGGGTGTTCCCGCGACAGGG	0.635																		7	8	---	---								-	42462957	GGTGTTCC	-	42462950	7	5	16	1	0	1	0	1	0	0	0	0	7876	1219	43	0	2684	0	ITGA2B	17	42462950	Frame_Shift_Del	DEL	GGTGTTCC	TCGA-BT-A2LB-01A-11D-A18F-08	35833	42462950	38732260	591	4314										
FMNL1	752	broad.mit.edu	37	chr17	43318986	43318986	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgactccgggggtgccgaccGgctcccccagcccaggtgcg	15	18	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:43318986G>C	uc002iin.2	+	14	1770	c.1570G>C	c.(1570-1572)GGC>CGC	p.G524R	FMNL1_uc002iiq.2_Missense_Mutation_p.G102R|FMNL1_uc010dag.2_5'Flank	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	524	Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						GGTGCCGACCGGCTCCCCCAG	0.716													0	0	0	0.001168	0	4	5										C	43318986	G	C	43318986	3	2	16	1	0	0	0	0	1	0	0	0	5951	1116	39	4	1624	4	FMNL1	17	43318986	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	856036	43318986	37876224	592	4315										
WNT9B	7484	broad.mit.edu	37	chr17	44954078	44954078	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gagcttgtgtacacctgcaaGcactaggcctactgcccagc	10	14	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:44954078G>A	uc002ikw.1	+	4	1105	c.1068G>A	c.(1066-1068)AAG>AAA	p.K356K	WNT9B_uc002ikx.1_Intron	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	356					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			ACACCTGCAAGCACTAGGCCT	0.627													0	0	0	0.010729	0	12	31										A	44954078	G	A	44954078	2	1	16	1	0	0	0	0	0	0	0	1	17396	962	34	2		2	WNT9B	17	44954078	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1635092	44954078	36241132	593	4316										
NPEPPS	9520	broad.mit.edu	37	chr17	45689897	45689897	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caggacataaggcaacgttaGaagaagcccgtcgtcggttt	12	9	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:45689897G>A	uc002ilr.3	+	18	2390	c.2167G>A	c.(2167-2169)GAA>AAA	p.E723K	NPEPPS_uc010wkt.1_Missense_Mutation_p.E719K|NPEPPS_uc010wku.1_Missense_Mutation_p.E687K|NPEPPS_uc010wkv.1_Missense_Mutation_p.E277K|NPEPPS_uc002ils.1_Missense_Mutation_p.E156K	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	723					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						GGCAACGTTAGAAGAAGCCCG	0.458													0	0	0	0.00499	0	16	55										A	45689897	G	A	45689897	3	1	16	1	0	0	0	0	1	0	0	0	10575	943	33	1	2237	1	NPEPPS	17	45689897	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	735819	45689897	35505313	594	4317										
SNX11	29916	broad.mit.edu	37	chr17	46189426	46189426	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgggcttttggtgtaggatGtcggagaaccaagaacagga	15	5	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:46189426G>A	uc002inf.1	+	3	375	c.21G>A	c.(19-21)ATG>ATA	p.M7I	SNX11_uc010wlg.1_5'UTR|SNX11_uc010wlh.1_5'UTR|SNX11_uc010wli.1_5'UTR|SNX11_uc010wlj.1_Intron|SNX11_uc002ing.1_Missense_Mutation_p.M7I|SNX11_uc002inh.1_Missense_Mutation_p.M7I	NM_152244	NP_689450	Q9Y5W9	SNX11_HUMAN	sorting nexin 11	7					cell communication|protein transport	membrane	phosphatidylinositol binding				0						GGTGTAGGATGTCGGAGAACC	0.458													0	0	0	0.013537	0	12	51										A	46189426	G	A	46189426	3	1	16	1	0	0	0	0	1	0	0	0	14882	1377	48	2	23	2	SNX11	17	46189426	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	499529	46189426	35005784	595	4318										
HOXB8	3218	broad.mit.edu	37	chr17	46690570	46690570	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtcccagctgaagcctacttCttgtcgcccttctgcgcgtc	9	16	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:46690570C>T	uc002inw.2	-	2	961	c.726G>A	c.(724-726)AAG>AAA	p.K242K	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	242						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGCCTACTTCTTGTCGCCCT	0.468													0	0	0	0.007413	0	16	83										T	46690570	C	T	46690570	2	4	16	1	0	0	0	0	0	0	0	1	7307	912	32	1		1	HOXB8	17	46690570	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	501144	46690570	34504640	596	4319										
SNF8	11267	broad.mit.edu	37	chr17	47013602	47013602	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tagttcctccaaagttatcaGacctgtttggagacagggaa	10	8	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:47013602G>A	uc002ioj.2	-	5	410	c.352C>T	c.(352-354)CTG>TTG	p.L118L	SNF8_uc002iok.2_Silent_p.L118L	NM_007241	NP_009172	Q96H20	SNF8_HUMAN	EAP30 subunit of ELL complex	118					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding				0						AAAGTTATCAGACCTGTTTGG	0.428													0	0	0	0.009096	0	3	24										A	47013602	G	A	47013602	2	1	16	1	0	0	0	0	0	0	0	1	14846	933	33	1		1	SNF8	17	47013602	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	323032	47013602	34181608	597	4320										
PHB	5245	broad.mit.edu	37	chr17	47486813	47486813	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggccggaagaggatgcgcagTgtgatgttgacattctgtaa	15	6	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:47486813T>C	uc002iox.1	-	4	346	c.273A>G	c.(271-273)ACA>ACG	p.T91T		NM_002634	NP_002625	P35232	PHB_HUMAN	prohibitin	91					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding				0	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			GGATGCGCAGTGTGATGTTGA	0.448													0	0	0	0.00632	0	26	55										C	47486813	T	C	47486813	2	2	16	1	0	0	0	0	0	0	0	1	11814	1683	59	5		5	PHB	17	47486813	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	473211	47486813	33708397	598	4321										
EME1	146956	broad.mit.edu	37	chr17	48450605	48450605	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatctacttccgggccctgcGtggcagttgaaagagtggcg	15	10	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:48450605G>A	uc002iqs.1	+	1	16	c.-57G>A	c.(-59--55)GCGTG>GCATG		MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_5'Flank	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1						DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			CGGGCCCTGCGTGGCAGTTGA	0.597								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.009096	0	4	4										A	48450605	G	A	48450605	1	1	16	1	0	0	0	0	0	0	0	0	5088	1160	40	2		2	EME1	17	48450605	Translation_Start_Site	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	963792	48450605	32744605	599	4322										
CUEDC1	404093	broad.mit.edu	37	chr17	55950043	55950043	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctctctccagagcgaggagGaagtcgcggttccgttgcag	14	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:55950043G>A	uc002ivd.1	-	5	1484	c.765C>T	c.(763-765)TTC>TTT	p.F255F	CUEDC1_uc002ive.1_Silent_p.F255F	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	255										skin(2)	2						GAGCGAGGAGGAAGTCGCGGT	0.597													0	0	0	0.001168	0	5	37										A	55950043	G	A	55950043	2	1	16	1	0	0	0	0	0	0	0	1	4052	1165	41	1		1	CUEDC1	17	55950043	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7499438	55950043	25245167	600	4323										
RAD51C	5889	broad.mit.edu	37	chr17	56774148	56774148	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagagggaagttttatggttGatagagtggtagaccttgct	14	4	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:56774148G>A	uc002iwu.2	+	3	541	c.499G>A	c.(499-501)GAT>AAT	p.D167N	RAD51C_uc010woa.1_Missense_Mutation_p.D167N|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	167					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTTATGGTTGATAGAGTGGT	0.413								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.008361	0	29	42										A	56774148	G	A	56774148	3	1	16	1	0	0	0	0	1	0	0	0	12988	1290	45	1	513	1	RAD51C	17	56774148	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	824105	56774148	24421062	601	4324										
RAD51C	5889	broad.mit.edu	37	chr17	56780655	56780655	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cagagttactggcacaagttTatcttcttccagatttcctt	6	10	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:56780655T>C	uc002iwu.2	+	4	712	c.670T>C	c.(670-672)TAT>CAT	p.Y224H	RAD51C_uc010woa.1_Missense_Mutation_p.Y224H|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	224					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCACAAGTTTATCTTCTTCC	0.348								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.003954	0	24	42										C	56780655	T	C	56780655	3	2	16	1	0	0	0	0	1	0	0	0	12988	1754	61	5	688	5	RAD51C	17	56780655	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	6507	56780655	24414555	602	4325										
TRIM37	4591	broad.mit.edu	37	chr17	57181659	57181659	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agaaatacaacttaccctaaTacagctgaaacaacacagtt	4	10	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:57181659T>C	uc002iwy.3	-	2	562	c.118A>G	c.(118-120)ATT>GTT	p.I40V	TRIM37_uc002iwz.3_Missense_Mutation_p.I40V|TRIM37_uc002ixa.3_5'UTR|TRIM37_uc010woc.1_Intron|uc002ixb.2_5'Flank	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	40	RING-type; degenerate.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTTACCCTAATACAGCTGAAA	0.353									Mulibrey_Nanism				0	0	0	0.004482	0	8	26										C	57181659	T	C	57181659	3	2	16	1	0	0	0	0	1	0	0	0	16508	1406	49	5	2876	5	TRIM37	17	57181659	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	401004	57181659	24013551	603	4326										
KCNH6	81033	broad.mit.edu	37	chr17	61615788	61615788	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caggtgctgaagggcttcccCgagtgcctgcaggctgacat	14	12	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:61615788C>T	uc002jay.2	+	8	1799	c.1719C>T	c.(1717-1719)CCC>CCT	p.P573P	KCNH6_uc010wpl.1_Silent_p.P450P|KCNH6_uc010wpm.1_Silent_p.P573P|KCNH6_uc002jaz.1_Silent_p.P520P	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	573	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGGGCTTCCCCGAGTGCCTGC	0.731													0	0	0	0.008291	0	8	13										T	61615788	C	T	61615788	2	4	16	1	0	0	0	0	0	0	0	1	8036	639	23	2		2	KCNH6	17	61615788	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4434129	61615788	19579422	604	4327										
POLG2	11232	broad.mit.edu	37	chr17	62493064	62493064	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcagaccttatggcaggccCtgacggctacacgagagcgc	13	13	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:62493064C>T	uc002jei.2	-	1	106	c.23G>A	c.(22-24)AGG>AAG	p.R8K	POLG2_uc010deg.1_Missense_Mutation_p.R8K	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	8					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			ATGGCAGGCCCTGACGGCTAC	0.567													0	0	0	0.006122	0	16	53										T	62493064	C	T	62493064	3	4	16	1	0	0	0	0	1	0	0	0	12201	681	24	2	1466	2	POLG2	17	62493064	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	877276	62493064	18702146	605	4328										
BTBD17	388419	broad.mit.edu	37	chr17	72352856	72352856	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acgatgaggtgcaggtgcagGgcgttctcaaccaggtactc	14	10	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:72352856G>T	uc002jkn.2	-	3	1377	c.1377C>A	c.(1375-1377)GCC>GCA	p.A459A		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	459						extracellular region					0						GCAGGTGCAGGGCGTTCTCAA	0.647													1	0	2.98393e-07	0.00278	3.13295e-07	20	72										T	72352856	G	T	72352856	2	4	16	1	0	0	0	0	0	0	0	1	1542	1219	43	4		4	BTBD17	17	72352856	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	9859792	72352856	8842354	606	4329										
GRIN2C	2905	broad.mit.edu	37	chr17	72848655	72848655	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcaggctggtgatgacggcGaaggcgctccagtcgtactc	15	11	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:72848655G>A	uc002jlt.1	-	3	651	c.495C>T	c.(493-495)TTC>TTT	p.F165F	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.F165F|GRIN2C_uc002jlv.1_3'UTR	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	165	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGATGACGGCGAAGGCGCTCC	0.701													0	0	0	0.004482	0	6	17										A	72848655	G	A	72848655	2	1	16	1	0	0	0	0	0	0	0	1	6781	1049	37	1		1	GRIN2C	17	72848655	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	495799	72848655	8346555	607	4330										
CASKIN2	57513	broad.mit.edu	37	chr17	73498946	73498946	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acaaagcttagggggccgctCtgtgccctctgggaggttcc	14	12	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:73498946C>G	uc002joc.2	-	18	2759	c.2209G>C	c.(2209-2211)GAG>CAG	p.E737Q	CASKIN2_uc010wsc.1_Missense_Mutation_p.E655Q	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	737	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGGGCCGCTCTGTGCCCTCT	0.657													0	0	0	0.000602	0	4	27										G	73498946	C	G	73498946	3	3	16	1	0	0	0	0	1	0	0	0	2667	922	32	1	1411	1	CASKIN2	17	73498946	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	650291	73498946	7696264	608	4331										
TSEN54	283989	broad.mit.edu	37	chr17	73515107	73515107	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctgaagaggttgggttatgTggttcgacgattccaaccaa	12	8	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:73515107T>C	uc002jof.1	+	6	533	c.500T>C	c.(499-501)GTG>GCG	p.V167A	TSEN54_uc002joe.1_Silent_p.C164C	NM_207346	NP_997229	Q7Z6J9	SEN54_HUMAN	tRNA splicing endonuclease 54 homolog	167					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	nucleolus				ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGGGTTATGTGGTTCGACGA	0.453													0	0	0	0.01441	0	43	72										C	73515107	T	C	73515107	3	2	16	1	0	0	0	0	1	0	0	0	16611	1696	59	5	522	5	TSEN54	17	73515107	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	16161	73515107	7680103	609	4332										
UNK	85451	broad.mit.edu	37	chr17	73813469	73813469	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgcggctccccaccgggctcCatcaggaagcccccaaacct	9	19	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:73813469C>T	uc002jpm.2	+	10	1395	c.1395C>T	c.(1393-1395)TCC>TCT	p.S465S		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	389							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCGGGCTCCATCAGGAAGC	0.657													0	0	0	0.00278	0	20	83										T	73813469	C	T	73813469	2	4	16	1	0	0	0	0	0	0	0	1	16997	581	21	2		2	UNK	17	73813469	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	298362	73813469	7381741	610	4333										
QRICH2	84074	broad.mit.edu	37	chr17	74288992	74288992	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgggccaaaccagactgatCcattccaggccggaccaaac	9	14	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:74288992C>A	uc002jrd.1	-	4	1498	c.1318G>T	c.(1318-1320)GAT>TAT	p.D440Y	QRICH2_uc010wsz.1_Missense_Mutation_p.D366Y|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	440	Gln-rich.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						ccagactgatccattccaggc	0.119													1	0	0.000442599	0.006214	0.000456911	9	20										A	74288992	C	A	74288992	3	1	16	1	0	0	0	0	1	0	0	0	12880	855	30	3	3737	3	QRICH2	17	74288992	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	475523	74288992	6906218	611	4334										
TMC8	147138	broad.mit.edu	37	chr17	76134245	76134245	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgctgaatagcgtcttcctCttcctcaccttctacatcaa	4	15	5	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:76134245C>T	uc002jup.2	+	12	1891	c.1509C>T	c.(1507-1509)CTC>CTT	p.L503L	TMC8_uc002juq.2_Silent_p.L280L|TMC8_uc010wtr.1_3'UTR|TMC8_uc002jur.1_5'UTR	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	503	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GCGTCTTCCTCTTCCTCACCT	0.617									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.00245	0	13	66										T	76134245	C	T	76134245	2	4	16	1	0	0	0	0	0	0	0	1	15988	900	32	1		1	TMC8	17	76134245	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1845253	76134245	5060965	612	4335										
DNAH17	8632	broad.mit.edu	37	chr17	76430168	76430168	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggagatggtgaggtccccgTtgttgaaggggtacgaccgg	18	7	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:76430168T>C	uc010dhp.1	-	20	3389	c.3167A>G	c.(3166-3168)AAC>AGC	p.N1056S	DNAH17_uc002jvq.2_Missense_Mutation_p.N341S|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAGGTCCCCGTTGTTGAAGGG	0.567													0	0	0	0.013726	0	30	126										C	76430168	T	C	76430168	3	2	16	1	0	0	0	0	1	0	0	0	4601	1725	60	5	1249	5	DNAH17	17	76430168	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	295923	76430168	4765042	613	4336										
SLC38A10	124565	broad.mit.edu	37	chr17	79220205	79220205	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccctgggggcggcatccttCtggccatctctcagcttggc	13	15	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:79220205C>T	uc002jzz.1	-	16	2886	c.2511G>A	c.(2509-2511)CAG>CAA	p.Q837Q	SLC38A10_uc002jzy.1_Silent_p.Q755Q	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	837					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGGCATCCTTCTGGCCATCTC	0.716													0	0	0	0.00308	0	7	25										T	79220205	C	T	79220205	2	4	16	1	0	0	0	0	0	0	0	1	14602	912	32	1		1	SLC38A10	17	79220205	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2790037	79220205	1975005	614	4337										
SLC38A10	124565	broad.mit.edu	37	chr17	79257211	79257211	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccctgaacacatccttacctGaaacccgaacagccgggcaa	7	16	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:79257211G>A	uc002jzz.1	-	4	730	c.355C>T	c.(355-357)CAG>TAG	p.Q119*	SLC38A10_uc002jzy.1_Nonsense_Mutation_p.Q37*|SLC38A10_uc002kab.2_Nonsense_Mutation_p.Q119*	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	119					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ATCCTTACCTGAAACCCGAAC	0.602													0	0	0	0.008291	0	9	12										A	79257211	G	A	79257211	4	1	16	1	0	0	0	0	0	1	0	0	14602	1299	45	1	3334	1	SLC38A10	17	79257211	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	37006	79257211	1937999	615	4338										
ASPSCR1	79058	broad.mit.edu	37	chr17	79954451	79954451	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tccggaggacgcggacacctCagggccctgctgcgagcaca	14	15	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:79954451C>T	uc002kcx.2	+	7	759	c.662C>T	c.(661-663)TCA>TTA	p.S221L	ASPSCR1_uc002kcw.1_Missense_Mutation_p.S221L|ASPSCR1_uc002kcy.2_Missense_Mutation_p.S221L|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Missense_Mutation_p.S144L|ASPSCR1_uc002kdb.1_Missense_Mutation_p.S144L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	221							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GCGGACACCTCAGGGCCCTGC	0.682			T	TFE3	alveolar soft part sarcoma								0	0	0	0.001168	0	6	23										T	79954451	C	T	79954451	3	4	16	1	0	0	0	0	1	0	0	0	1059	838	29	1	688	1	ASPSCR1	17	79954451	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	697240	79954451	1240759	616	4339										
TBCD	6904	broad.mit.edu	37	chr17	80899327	80899327	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcaaccgtctgtgtgaccttCtgggcgtacccaggccccag	12	15	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:80899327C>T	uc002kfz.2	+	38	3662	c.3532C>T	c.(3532-3534)CTG>TTG	p.L1178L	TBCD_uc002kfy.1_Silent_p.L1216L|TBCD_uc002kgc.2_Silent_p.L297L|TBCD_uc002kgd.2_Silent_p.L170L	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	1178					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GTGTGACCTTCTGGGCGTACC	0.627													0	0	0	0.004672	0	3	8										T	80899327	C	T	80899327	2	4	16	1	0	0	0	0	0	0	0	1	15630	912	32	1		1	TBCD	17	80899327	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	944876	80899327	295883	617	4340										
YES1	7525	broad.mit.edu	37	chr18	724590	724590	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctgagggcacggcatcctgTatcctcgctccacttgttct	9	15	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:724590T>C	uc002kky.2	-	12	1687	c.1466A>G	c.(1465-1467)TAC>TGC	p.Y489C	YES1_uc002kkz.2_Missense_Mutation_p.Y489C	NM_005433	NP_005424	P07947	YES_HUMAN	viral oncogene yes-1 homolog 1	489	Protein kinase.				blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|ovary(1)	3					Dasatinib(DB01254)	CGGCATCCTGTATCCTCGCTC	0.413													0	0	0	0.00278	0	23	58										C	724590	T	C	724590	3	2	16	1	0	0	0	0	1	0	0	0	17471	1638	57	5	169	5	YES1	18	724590	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08		724590	77352658	618	4341										
SMCHD1	23347	broad.mit.edu	37	chr18	2750410	2750410	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tatcatagaaggacctataaTtaagttaatgattcttccag	6	6	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:2750410T>C	uc002klm.3	+	32	4259	c.4070T>C	c.(4069-4071)ATT>ACT	p.I1357T	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1357					chromosome organization		ATP binding				0						GGACCTATAATTAAGTTAATG	0.383													0	0	0	0.010729	0	11	29										C	2750410	T	C	2750410	3	2	16	1	0	0	0	0	1	0	0	0	14788	1493	52	5	4196	5	SMCHD1	18	2750410	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	2025820	2750410	75326838	619	4342										
AFG3L2	10939	broad.mit.edu	37	chr18	12337383	12337383	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgtgagaagagctactgttCttttataagcatcattaata	7	6	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:12337383C>G	uc002kqz.1	-	16	2245	c.2132G>C	c.(2131-2133)AGA>ACA	p.R711T		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	711					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	AGCTACTGTTCTTTTATAAGC	0.393													0	0	0	0.00333	0	22	38										G	12337383	C	G	12337383	3	3	16	1	0	0	0	0	1	0	0	0	360	913	32	1	269	1	AFG3L2	18	12337383	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	9586973	12337383	65739865	620	4343										
POTEC	388468	broad.mit.edu	37	chr18	14534973	14534973	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caccacttgctgtttttgttCatgtacgccaagcaaaagtg	8	10	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:14534973C>T	uc010dln.2	-	4	1298	c.844G>A	c.(844-846)GAA>AAA	p.E282K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	282	ANK 5.									skin(3)	3						TGTTTTTGTTCATGTACGCCA	0.303													0	0	0	0.006214	0	5	56										T	14534973	C	T	14534973	3	4	16	1	0	0	0	0	1	0	0	0	12262	835	29	1	816	1	POTEC	18	14534973	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2197590	14534973	63542275	621	4344										
C18orf8	29919	broad.mit.edu	37	chr18	21084405	21084405	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agatgataggaatcccatctCatttaggtaatggtatagac	9	6	1	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:21084405C>G	uc010xax.1	+	2	294	c.173C>G	c.(172-174)TCA>TGA	p.S58*	C18orf8_uc010xau.1_5'UTR|C18orf8_uc010xav.1_Nonsense_Mutation_p.S58*|C18orf8_uc010xaw.1_5'UTR|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	58										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AATCCCATCTCATTTAGGTAA	0.378													0	0	0	0.013726	0	29	83										G	21084405	C	G	21084405	4	3	16	1	0	0	0	0	0	1	0	0	1907	838	29	1	179	1	C18orf8	18	21084405	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6549432	21084405	56992843	622	4345										
NPC1	4864	broad.mit.edu	37	chr18	21148963	21148963	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tataaaaacaggatggacatCtaaaggaaaagtaaattata	7	3	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:21148963C>T	uc002kum.3	-	4	562	c.288_splice	c.e4-1	p.R96_splice	NPC1_uc010xba.1_Splice_Site	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor						autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GGATGGACATCTAAAGGAAAA	0.338													0	0	0	0.00308	0	6	16										T	21148963	C	T	21148963	5	4	16	1	0	0	0	0	0	0	1	0	10570	927	32	1	3637	1	NPC1	18	21148963	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	64558	21148963	56928285	623	4346										
ZNF521	25925	broad.mit.edu	37	chr18	22805190	22805190	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgattctgcagcaaagtttCcatagtgtaggctgccccac	10	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:22805190C>A	uc002kvk.2	-	4	2939	c.2692G>T	c.(2692-2694)GAA>TAA	p.E898*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.E898*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.E678*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	898	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGCAAAGTTTCCATAGTGTAG	0.502			T	PAX5	ALL								1	0	1.75199e-13	0.007291	1.88071e-13	29	35										A	22805190	C	A	22805190	4	1	16	1	0	0	0	0	0	1	0	0	17962	864	30	3	1263	3	ZNF521	18	22805190	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1656227	22805190	55272058	624	4347										
KIAA1012	22878	broad.mit.edu	37	chr18	29419397	29419397	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttttctggcctgaaaaatttCaatagttccatttctggtgg	8	7	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:29419397C>G	uc002kxc.3	-	27	4225	c.3861G>C	c.(3859-3861)TTG>TTC	p.L1287F	KIAA1012_uc002kxb.3_Missense_Mutation_p.L1233F|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1287					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TGAAAAATTTCAATAGTTCCA	0.328													0	0	0	0.001855	0	13	44										G	29419397	C	G	29419397	3	3	16	1	0	0	0	0	1	0	0	0	8204	825	29	1	458	1	KIAA1012	18	29419397	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6614207	29419397	48657851	625	4348										
KATNAL2	83473	broad.mit.edu	37	chr18	44595908	44595908	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	actgaatgtaaaacaaccttCtttaacatttctgcatccac	3	11	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:44595908C>T	uc002lco.2	+	10	923	c.729C>T	c.(727-729)TTC>TTT	p.F243F	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Silent_p.F170F	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	315						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						AAACAACCTTCTTTAACATTT	0.378													0	0	0	0.004007	0	16	49										T	44595908	C	T	44595908	2	4	16	1	0	0	0	0	0	0	0	1	7986	912	32	1		1	KATNAL2	18	44595908	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	15176511	44595908	33481340	626	4349										
C19orf35	374872	broad.mit.edu	37	chr19	2276228	2276228	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacgcctccaggaacttcagGgccgcgctcagctgcagcag	12	16	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:2276228G>A	uc002lvn.2	-	4	973	c.873C>T	c.(871-873)GCC>GCT	p.A291A	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	291										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAACTTCAGGGCCGCGCTCA	0.726													0	0	0	0.001168	0	6	3										A	2276228	G	A	2276228	2	1	16	1	0	0	0	0	0	0	0	1	1920	1219	43	2		2	C19orf35	19	2276228	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		2276228	56852755	627	4350										
GTF2F1	2962	broad.mit.edu	37	chr19	6381161	6381161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agagggctgaggaggcctcgCtgtcaatgtcgctctcctct	13	12	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:6381161C>T	uc002meq.2	-	10	1349	c.1064G>A	c.(1063-1065)AGC>AAC	p.S355N	GTF2F1_uc010xjb.1_Missense_Mutation_p.S176N|GTF2F1_uc010xjc.1_Missense_Mutation_p.S270N	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	355					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GGAGGCCTCGCTGTCAATGTC	0.677													0	0	0	0.00308	0	7	7										T	6381161	C	T	6381161	3	4	16	1	0	0	0	0	1	0	0	0	6858	797	28	2	505	2	GTF2F1	19	6381161	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4104933	6381161	52747822	628	4351										
TIMM44	10469	broad.mit.edu	37	chr19	7992108	7992108	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgctggaggccgagatgtcCaggagccgccaggccgcgta	17	12	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:7992108C>T	uc002miz.2	-	13	1325	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	TIMM44_uc002mja.2_Silent_p.L181L|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	441					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CCGAGATGTCCAGGAGCCGCC	0.672													0	0	0	0.007413	0	19	21										T	7992108	C	T	7992108	2	4	16	1	0	0	0	0	0	0	0	1	15909	581	21	2		2	TIMM44	19	7992108	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1610947	7992108	51136875	629	4352										
MUC16	94025	broad.mit.edu	37	chr19	9057298	9057298	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggggtgaggagtgaagtcaCagaaaaagaggaggaaggga	19	2	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:9057298C>T	uc002mkp.2	-	3	30352	c.30148G>A	c.(30148-30150)GTG>ATG	p.V10050M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10052	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTGAAGTCACAGAAAAAGAG	0.463													0	0	0	0.004007	0	16	24										T	9057298	C	T	9057298	3	4	16	1	0	0	0	0	1	0	0	0	9973	478	17	2	13703	2	MUC16	19	9057298	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1065190	9057298	50071685	630	4353										
MAN2B1	4125	broad.mit.edu	37	chr19	12758381	12758381	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccagcgtgagcaggtgcaccGagggcggcaggtccctgcgc	17	14	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:12758381G>A	uc002mub.2	-	22	2772	c.2696C>T	c.(2695-2697)TCG>TTG	p.S899L	MAN2B1_uc010dyv.1_Missense_Mutation_p.S898L	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	899					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						CAGGTGCACCGAGGGCGGCAG	0.692													0	0	0	0.007291	0	27	23										A	12758381	G	A	12758381	3	1	16	1	0	0	0	0	1	0	0	0	9216	1059	37	1	351	1	MAN2B1	19	12758381	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3701083	12758381	46370602	631	4354										
TNPO2	30000	broad.mit.edu	37	chr19	12825962	12825962	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccgcacctcggggtcatcatCcacagccagggcaaataggt	11	14	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:12825962C>T	uc002muo.2	-	8	855	c.670G>A	c.(670-672)GAT>AAT	p.D224N	TNPO2_uc002mup.2_Missense_Mutation_p.D316N|TNPO2_uc002muq.2_Missense_Mutation_p.D224N|TNPO2_uc002mur.2_Missense_Mutation_p.D224N	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	224	HEAT 3.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						GGGTCATCATCCACAGCCAGG	0.622													0	0	0	0.00278	0	18	27										T	12825962	C	T	12825962	3	4	16	1	0	0	0	0	1	0	0	0	16333	855	30	1	2091	1	TNPO2	19	12825962	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	67581	12825962	46303021	632	4355										
SYDE1	85360	broad.mit.edu	37	chr19	15223296	15223296	+	Frame_Shift_Del	DEL	C	C	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcgcccacaaggcctcgtgCccgcagctccggcccaggcc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:15223296delC	uc002nah.1	+	7	1749	c.1718delC	c.(1717-1719)GCCfs	p.A573fs	SYDE1_uc002nai.1_Frame_Shift_Del_p.A506fs|SYDE1_uc002naj.1_Frame_Shift_Del_p.A230fs	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	573	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						AGGCCTCGTGCCCGCAGCTCC	0.647																		12	14	---	---								-	15223296	C	-	15223296	7	5	16	1	0	1	0	1	0	0	0	0	15432	739	26	0	1744	0	SYDE1	19	15223296	Frame_Shift_Del	DEL	C	TCGA-BT-A2LB-01A-11D-A18F-08	2397334	15223296	43905687	633	4356										
RASAL3	64926	broad.mit.edu	37	chr19	15562677	15562677	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaagacccccgcgtccttgGagaaagctgcaggctctgga	12	14	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:15562677G>A	uc002nbe.2	-	18	3051	c.2965C>T	c.(2965-2967)CCA>TCA	p.P989S	WIZ_uc002nbb.3_5'Flank|RASAL3_uc002nbd.2_3'UTR|RASAL3_uc010eaa.1_Missense_Mutation_p.P403S	NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	989					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						CGCGTCCTTGGAGAAAGCTGC	0.602													0	0	0	0.007291	0	31	24										A	15562677	G	A	15562677	3	1	16	1	0	0	0	0	1	0	0	0	13065	1174	41	1	74	1	RASAL3	19	15562677	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	339381	15562677	43566306	634	4357										
NDUFA13	51079	broad.mit.edu	37	chr19	19626839	19626839	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacgccctgtctgggcaaaaGaggagtaaagacccctcagc	11	13	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:19626839G>C	uc010xqy.1	+	1	300	c.41G>C	c.(40-42)AGA>ACA	p.R14T	TSSK6_uc002nmq.2_5'Flank|TSSK6_uc002nmr.2_5'Flank|NDUFA13_uc002nms.2_Missense_Mutation_p.R14T|NDUFA13_uc010xqx.1_Missense_Mutation_p.R14T	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CTGGGCAAAAGAGGAGTAAAG	0.612													0	0	0	0.006122	0	18	20										C	19626839	G	C	19626839	3	2	16	1	0	0	0	0	1	0	0	0	10263	957	33	1		1	NDUFA13	19	19626839	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4064162	19626839	39502144	635	4358										
RYR1	6261	broad.mit.edu	37	chr19	39068655	39068655	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gatcacagcccacaatgagcGcaagcccaacccgccgccag	9	18	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:39068655G>A	uc002oit.2	+	98	14400	c.14270G>A	c.(14269-14271)CGC>CAC	p.R4757H	RYR1_uc002oiu.2_Missense_Mutation_p.R4752H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4757					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CACAATGAGCGCAAGCCCAAC	0.632													0	0	0	0.004007	0	14	27										A	39068655	G	A	39068655	3	1	16	1	0	0	0	0	1	0	0	0	13768	1087	38	2	14660	2	RYR1	19	39068655	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	19441816	39068655	20060328	636	4359										
FCGBP	8857	broad.mit.edu	37	chr19	40366091	40366091	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcctgacaggctgccacgtAggtagccactgcaggacaga	14	12	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:40366091A>G	uc002omp.3	-	30	14151	c.14143T>C	c.(14143-14145)TAC>CAC	p.Y4715H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4715						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCTGCCACGTAGGTAGCCACT	0.662													0	0	0	0.010771	0	42	20										G	40366091	A	G	40366091	3	3	16	1	0	0	0	0	1	0	0	0	5778	420	15	5	2102	5	FCGBP	19	40366091	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	1297436	40366091	18762892	637	4360										
SHKBP1	92799	broad.mit.edu	37	chr19	41096303	41096303	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgtgggacctaaccaccgcCatggacggcctcggccaggc	13	15	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:41096303C>T	uc002oob.2	+	16	1792	c.1743C>T	c.(1741-1743)GCC>GCT	p.A581A	SHKBP1_uc002ooc.2_Silent_p.A556A|SHKBP1_uc002ood.2_Intron|SHKBP1_uc010xvl.1_Silent_p.A504A|SHKBP1_uc002ooe.2_Silent_p.A418A|SHKBP1_uc002oof.2_Silent_p.A418A|SHKBP1_uc010xvm.1_Silent_p.A361A|SHKBP1_uc010xvn.1_Silent_p.A459A|LTBP4_uc002oog.1_5'Flank	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	581	WD 5.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TAACCACCGCCATGGACGGCC	0.697													0	0	0	0.003954	0	23	12										T	41096303	C	T	41096303	2	4	16	1	0	0	0	0	0	0	0	1	14284	581	21	2		2	SHKBP1	19	41096303	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	730212	41096303	18032680	638	4361										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41808719	41808745	+	In_Frame_Del	DEL	GGTGGTGGTGGCTTCCGGGGCCGCGGG	GGTGGTGGTGGCTTCCGGGGCCGCGGG	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaaagcgctttgacaaccgaGgtggtggtggcttccggggc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:41808719_41808745delGGTGGTGGTGGCTTCCGGGGCCGCGGG	uc002oqb.3	+	12	2126_2152	c.1837_1863delGGTGGTGGTGGCTTCCGGGGCCGCGGG	c.(1837-1863)GGTGGTGGTGGCTTCCGGGGCCGCGGGdel	p.GGGGFRGRG613del	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc002oqa.3_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010ehm.2_In_Frame_Del_p.GGGGFRGRG613del|HNRNPUL1_uc002oqc.3_In_Frame_Del_p.GGGGFRGRG499del|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010ehn.2_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010eho.2_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010xvy.1_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010ehp.2_In_Frame_Del_p.GGGGFRGRG469del|HNRNPUL1_uc002oqf.3_In_Frame_Del_p.GGGGFRGRG137del	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	613_621	Necessary for transcription repression.|Necessary for interaction with TP53.|Gly-rich.|1-2.|5 X 3 AA repeats of R-G-G.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TGACAACCGAGGTGGTGGTGGCTTCCGGGGCCGCGGGGGTGGTGGTG	0.652																		10	47	---	---								-	41808745	GGTGGTGGTGGCTTCCGGGGCCGCGGG	-	41808719	7	5	16	1	0	1	0	1	0	0	0	0	7274	1000	35	0	1883	0	HNRNPUL1	19	41808719	In_Frame_Del	DEL	GGTGGTGGTGGCTTCCGGGGCCGCGGG	TCGA-BT-A2LB-01A-11D-A18F-08	712416	41808719	17320264	639	4362										
CNFN	84518	broad.mit.edu	37	chr19	42891312	42891312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagggaacttccttactctCggatcttcagttcccgcgcc	8	15	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:42891312C>T	uc002otp.3	-	4	387	c.332G>A	c.(331-333)CGA>CAA	p.R111Q	CNFN_uc002otq.3_Missense_Mutation_p.R124Q	NM_032488	NP_115877	Q9BYD5	CNFN_HUMAN	cornifelin	111					keratinization	cornified envelope|cytoplasm					0		Prostate(69;0.00899)				TCCTTACTCTCGGATCTTCAG	0.637													0	0	0	0.010504	0	18	16										T	42891312	C	T	42891312	3	4	16	1	0	0	0	0	1	0	0	0	3595	884	31	1	10	1	CNFN	19	42891312	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1082593	42891312	16237671	640	4363										
ZNF226	7769	broad.mit.edu	37	chr19	44680458	44680458	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaaaggtttcagtcgtagatCagcacttaatgttcattgca	9	7	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:44680458C>T	uc002oyp.2	+	6	1187	c.1043C>T	c.(1042-1044)TCA>TTA	p.S348L	ZNF226_uc002oyq.2_Missense_Mutation_p.S231L|ZNF226_uc002oyr.2_Missense_Mutation_p.S231L|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.S348L|ZNF226_uc002oyt.2_Missense_Mutation_p.S348L	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	348	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTCGTAGATCAGCACTTAAT	0.468													0	0	0	0.009718	0	43	28										T	44680458	C	T	44680458	3	4	16	1	0	0	0	0	1	0	0	0	17777	838	29	1	1111	1	ZNF226	19	44680458	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1789146	44680458	14448525	641	4364										
CLPTM1	1209	broad.mit.edu	37	chr19	45477814	45477814	+	Missense_Mutation	SNP	A	A	G													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gactagcggcgagaactcagAcggctgctacgagcactttg							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:45477814A>G	uc002pai.2	+	4	443	c.428A>G	c.(427-429)GAC>GGC	p.D143G	CLPTM1_uc010ejv.1_Missense_Mutation_p.D41G|CLPTM1_uc010xxf.1_Missense_Mutation_p.D41G|CLPTM1_uc010xxg.1_Missense_Mutation_p.D129G	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	143	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GAGAACTCAGACGGCTGCTAC	0.567													0	0	0	0.003271	0	33	27										G	45477814	A	G	45477814	3	3	16	1	0	0	0	0	1	0	0	0	3554	275	10	5	442	5	CLPTM1	19	45477814	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	797356	45477814	13651169	642	4365	22	2								
CLPTM1	1209	broad.mit.edu	37	chr19	45477816	45477816	+	Missense_Mutation	SNP	G	G	A													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctagcggcgagaactcagacGgctgctacgagcactttgct							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:45477816G>A	uc002pai.2	+	4	445	c.430G>A	c.(430-432)GGC>AGC	p.G144S	CLPTM1_uc010ejv.1_Missense_Mutation_p.G42S|CLPTM1_uc010xxf.1_Missense_Mutation_p.G42S|CLPTM1_uc010xxg.1_Missense_Mutation_p.G130S	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	144	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GAACTCAGACGGCTGCTACGA	0.572													0	0	0	0.013726	0	32	27										A	45477816	G	A	45477816	3	1	16	1	0	0	0	0	1	0	0	0	3554	1116	39	2	444	2	CLPTM1	19	45477816	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2	45477816	13651167	643	4366	22	2								
NUCB1	4924	broad.mit.edu	37	chr19	49422510	49422510	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttcctcgcatccactcagagGaaggagtttggggacaccgg	13	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:49422510G>T	uc002plb.3	+	10	1041	c.969G>T	c.(967-969)AGG>AGT	p.R323S	NUCB1_uc002pla.2_Missense_Mutation_p.R323S|NUCB1_uc002plc.2_Missense_Mutation_p.R323S|NUCB1_uc002pld.2_5'UTR	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	323	EF-hand 2.					ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		CCACTCAGAGGAAGGAGTTTG	0.602													1	0	1.58986e-06	0.008291	1.66318e-06	7	65										T	49422510	G	T	49422510	3	4	16	1	0	0	0	0	1	0	0	0	10718	1165	41	3	1003	3	NUCB1	19	49422510	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	3944694	49422510	9706473	644	4367										
TSKS	60385	broad.mit.edu	37	chr19	50243365	50243365	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttcttggcccgcagggcctCgtcttgggccagccgaaggg	16	13	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:50243365C>T	uc002ppm.2	-	10	1584	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	525							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CGCAGGGCCTCGTCTTGGGCC	0.632													0	0	0	0.01441	0	68	35										T	50243365	C	T	50243365	3	4	16	1	0	0	0	0	1	0	0	0	16623	893	31	1	213	1	TSKS	19	50243365	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	820855	50243365	8885618	645	4368										
NLRP2	55655	broad.mit.edu	37	chr19	55493759	55493759	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaactaatgctagactgggcAgaggacaacctcatccacaa	8	11	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:55493759A>G	uc002qij.2	+	6	779	c.693A>G	c.(691-693)GCA>GCG	p.A231A	NLRP2_uc010yfp.1_Silent_p.A208A|NLRP2_uc010esn.2_Silent_p.A207A|NLRP2_uc010eso.2_Silent_p.A228A|NLRP2_uc010esp.2_Silent_p.A209A	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	231	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TAGACTGGGCAGAGGACAACC	0.577													0	0	0	0.009535	0	29	17										G	55493759	A	G	55493759	2	3	16	1	0	0	0	0	0	0	0	1	10477	175	7	5		5	NLRP2	19	55493759	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	5250394	55493759	3635224	646	4369										
ZNF418	147686	broad.mit.edu	37	chr19	58441801	58441801	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgtgaggaacttacccaggGaggatataagtacccagttc	12	8	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:58441801G>A	uc002qqs.1	-	3	420	c.128C>T	c.(127-129)TCC>TTC	p.S43F	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Intron	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	43	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CTTACCCAGGGAGGATATAAG	0.488													0	0	0	0.01441	0	70	47										A	58441801	G	A	58441801	3	1	16	1	0	0	0	0	1	0	0	0	17892	1174	41	1	1910	1	ZNF418	19	58441801	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	2948042	58441801	687182	647	4370										
ZNF606	80095	broad.mit.edu	37	chr19	58489802	58489802	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tctgatgaataataagggaaGaattcttacaaaatgctttt	7	4	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:58489802G>A	uc002qqw.2	-	7	2864	c.2246C>T	c.(2245-2247)TCT>TTT	p.S749F	ZNF606_uc010yhp.1_Missense_Mutation_p.S659F	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	749	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AATAAGGGAAGAATTCTTACA	0.373													0	0	0	0.01441	0	73	32										A	58489802	G	A	58489802	3	1	16	1	0	0	0	0	1	0	0	0	18029	942	33	1	136	1	ZNF606	19	58489802	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	48001	58489802	639181	648	4371										
DEFB127	140850	broad.mit.edu	37	chr20	139536	139536	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agatactgttgcctcaatatCaaggaactggaagcatgtaa	9	7	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:139536C>T	uc002wcy.1	+	2	171	c.171C>T	c.(169-171)ATC>ATT	p.I57I		NM_139074	NP_620713	Q9H1M4	DB127_HUMAN	defensin, beta 127 preproprotein	57					defense response to bacterium|innate immune response	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			GCCTCAATATCAAGGAACTGG	0.393													0	0	0	0.003163	0	12	14										T	139536	C	T	139536	2	4	16	1	0	0	0	0	0	0	0	1	4413	816	29	1		1	DEFB127	20	139536	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08		139536	62885984	649	4372										
ANGPT4	51378	broad.mit.edu	37	chr20	896835	896835	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caaggaggaggctgccctgcAgcatggctagctgggagagc	17	10	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:896835A>G	uc002wei.2	-	1	126	c.23T>C	c.(22-24)CTG>CCG	p.L8P	ANGPT4_uc010zpn.1_Missense_Mutation_p.L2P	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	8					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GCTGCCCTGCAGCATGGCTAG	0.602													0	0	0	0.010504	0	17	42										G	896835	A	G	896835	3	3	16	1	0	0	0	0	1	0	0	0	612	188	7	5	1524	5	ANGPT4	20	896835	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	757299	896835	62128685	650	4373										
SDCBP2	27111	broad.mit.edu	37	chr20	1291531	1291531	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccagaatctccatgatctttTtgtcctagggaggaggcaag	11	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:1291531T>C	uc002wev.3	-	8	866	c.737A>G	c.(736-738)AAA>AGA	p.K246R	SDCBP2_uc002weu.3_Missense_Mutation_p.K161R	NM_080489	NP_536737	Q9H190	SDCB2_HUMAN	syndecan binding protein 2 isoform a	246	PDZ 2.				intracellular signal transduction|intracellular transport|nervous system development	cytoplasm	protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity			large_intestine(1)|skin(1)	2						CATGATCTTTTTGTCCTAGGG	0.537													0	0	0	0.004482	0	9	20										C	1291531	T	C	1291531	3	2	16	1	0	0	0	0	1	0	0	0	13956	1841	64	5	149	5	SDCBP2	20	1291531	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	394696	1291531	61733989	651	4374										
RASSF2	9770	broad.mit.edu	37	chr20	4778713	4778713	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tacaagttgtaggtcttcagAtgcaagagaagttcatttct	9	6	4	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:4778713A>T	uc002wld.2	-	3	132	c.78T>A	c.(76-78)CAT>CAA	p.H26Q	RASSF2_uc002wlc.2_5'Flank|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.H26Q	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	26					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						AGGTCTTCAGATGCAAGAGAA	0.473													0	0	0	0.012319	0	17	40										T	4778713	A	T	4778713	3	4	16	1	0	0	0	0	1	0	0	0	13086	330	12	5	938	5	RASSF2	20	4778713	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3487182	4778713	58246807	652	4375										
MCM8	84515	broad.mit.edu	37	chr20	5966679	5966679	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccacagaagctgctcgagttCttcaagatttttaccttgag	8	10	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:5966679C>T	uc002wmi.2	+	16	2442	c.2065C>T	c.(2065-2067)CTT>TTT	p.L689F	MCM8_uc002wmj.2_Missense_Mutation_p.L673F|MCM8_uc002wmk.2_Missense_Mutation_p.L729F|MCM8_uc002wml.2_Missense_Mutation_p.L689F|MCM8_uc010gbp.2_Missense_Mutation_p.L642F|MCM8_uc002wmm.2_Missense_Mutation_p.L227F	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	689					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						TGCTCGAGTTCTTCAAGATTT	0.463													0	0	0	0.004656	0	25	39										T	5966679	C	T	5966679	3	4	16	1	0	0	0	0	1	0	0	0	9393	913	32	1	2123	1	MCM8	20	5966679	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1187966	5966679	57058841	653	4376										
LRRN4	164312	broad.mit.edu	37	chr20	6025248	6025248	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gacaagtcacaactgcaagtGagggggttgccaaagaggtt	14	7	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:6025248G>C	uc002wmo.2	-	4	1163	c.939C>G	c.(937-939)CTC>CTG	p.L313L		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	313	Extracellular (Potential).					integral to membrane				skin(3)	3						AACTGCAAGTGAGGGGGTTGC	0.483													0	0	0	0.000602	0	5	14										C	6025248	G	C	6025248	2	2	16	1	0	0	0	0	0	0	0	1	9037	1277	45	1		1	LRRN4	20	6025248	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	58569	6025248	57000272	654	4377										
ESF1	51575	broad.mit.edu	37	chr20	13756530	13756530	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaaggttacctcatcagcacGaggagcatctttatctaatt	7	9	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:13756530G>A	uc002woj.2	-	3	1132	c.1024C>T	c.(1024-1026)CGT>TGT	p.R342C	ESF1_uc002wok.1_Missense_Mutation_p.R342C	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						TCATCAGCACGAGGAGCATCT	0.368													0	0	0	0.009535	0	33	41										A	13756530	G	A	13756530	3	1	16	1	0	0	0	0	1	0	0	0	5251	1058	37	1	1579	1	ESF1	20	13756530	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	7731282	13756530	49268990	655	4378										
CRNKL1	51340	broad.mit.edu	37	chr20	20020280	20020280	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgtctaaacgtggctgactGatggctaattcatagattgc	10	7	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:20020280G>A	uc002wrs.2	-	12	2033	c.2001C>T	c.(1999-2001)ATC>ATT	p.I667I		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	667	HAT 13.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						GTGGCTGACTGATGGCTAATT	0.378													0	0	0	0.00278	0	24	67										A	20020280	G	A	20020280	2	1	16	1	0	0	0	0	0	0	0	1	3891	1280	45	1		1	CRNKL1	20	20020280	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	6263750	20020280	43005240	656	4379										
RALGAPA2	57186	broad.mit.edu	37	chr20	20493296	20493296	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gttatgactctggatatactCatcctcttgagcattttggc	8	9	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:20493296C>T	uc002wrz.2	-	32	4860	c.4717G>A	c.(4717-4719)GAG>AAG	p.E1573K	RALGAPA2_uc010gcx.2_Missense_Mutation_p.E1277K|RALGAPA2_uc010zsg.1_Missense_Mutation_p.E1021K|RALGAPA2_uc002wsa.1_Missense_Mutation_p.E345K	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1573					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGGATATACTCATCCTCTTGA	0.468													0	0	0	0.001168	0	5	51										T	20493296	C	T	20493296	3	4	16	1	0	0	0	0	1	0	0	0	13014	835	29	1	936	1	RALGAPA2	20	20493296	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	473016	20493296	42532224	657	4380										
NAPB	63908	broad.mit.edu	37	chr20	23375803	23375803	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgtaaatgtcgatggctgcAtttaagcagttgatagcctc	11	7	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:23375803A>G	uc002wta.2	-	4	432	c.315T>C	c.(313-315)AAT>AAC	p.N105N	NAPB_uc002wtc.2_Intron|NAPB_uc002wtb.2_Silent_p.N109N|NAPB_uc002wtd.3_Intron|NAPB_uc010zss.1_5'UTR|NAPB_uc010zst.1_Silent_p.N66N	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	105					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					CGATGGCTGCATTTAAGCAGT	0.428													0	0	0	0.001855	0	12	17										G	23375803	A	G	23375803	2	3	16	1	0	0	0	0	0	0	0	1	10162	214	8	5		5	NAPB	20	23375803	Silent	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	2882507	23375803	39649717	658	4381										
CST4	1472	broad.mit.edu	37	chr20	23669392	23669392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cacccacctgctccctggctCgcagcacctgcagcgggcgt	11	19	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:23669392C>T	uc002wto.1	-	1	271	c.215G>A	c.(214-216)CGA>CAA	p.R72Q		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	72						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CTCCCTGGCTCGCAGCACCTG	0.597													0	0	0	0.004482	0	9	43										T	23669392	C	T	23669392	3	4	16	1	0	0	0	0	1	0	0	0	3974	884	31	1	222	1	CST4	20	23669392	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	293589	23669392	39356128	659	4382										
VSX1	30813	broad.mit.edu	37	chr20	25059543	25059543	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcagggtagtgggcctcgctGaatgccttctccaactcttc	10	13	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:25059543G>T	uc002wuf.2	-	3	584	c.549C>A	c.(547-549)TTC>TTA	p.F183L	VSX1_uc002wue.2_RNA|VSX1_uc010gdd.1_Missense_Mutation_p.F183L|VSX1_uc010gde.1_RNA|VSX1_uc010gdf.1_Missense_Mutation_p.F183L|VSX1_uc002wug.1_Missense_Mutation_p.F183L	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	183	Homeobox.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGCCTCGCTGAATGCCTTCT	0.567													1	0	1.62565e-12	0.012213	1.74076e-12	33	50										T	25059543	G	T	25059543	3	4	16	1	0	0	0	0	1	0	0	0	17228	1281	45	3	653	3	VSX1	20	25059543	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1390151	25059543	37965977	660	4383										
ZNF337	26152	broad.mit.edu	37	chr20	25657489	25657489	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atttccactacactgttcctCctccttgagcttactgcatg	5	14	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:25657489C>T	uc002wva.2	-	4	957	c.435G>A	c.(433-435)AGG>AGA	p.R145R	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Silent_p.R113R|ZNF337_uc002wvb.2_Silent_p.R145R|ZNF337_uc002wvc.2_Silent_p.R145R	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACTGTTCCTCCTCCTTGAGC	0.443													0	0	0	0.004289	0	31	144										T	25657489	C	T	25657489	2	4	16	1	0	0	0	0	0	0	0	1	17850	854	30	1		1	ZNF337	20	25657489	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	597946	25657489	37368031	661	4384										
ID1	3397	broad.mit.edu	37	chr20	30193214	30193214	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaagtcgccagtggcagcacCgccaccgccgccgcgggccc	13	19	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:30193214C>T	uc002wwg.1	+	1	123	c.24C>T	c.(22-24)ACC>ACT	p.T8T	ID1_uc002wwh.1_Silent_p.T8T|hsa-mir-3193|MI0014238_5'Flank	NM_002165	NP_002156	P41134	ID1_HUMAN	inhibitor of DNA binding 1 isoform a	8					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GTGGCAGCACCGCCACCGCCG	0.622													0	0	0	0.006122	0	14	29										T	30193214	C	T	30193214	2	4	16	1	0	0	0	0	0	0	0	1	7489	639	23	2		2	ID1	20	30193214	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4535725	30193214	32832306	662	4385										
NFS1	9054	broad.mit.edu	37	chr20	34286483	34286483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcagcggctgtatctgcggGaaccgcagactgaggagcac	16	11	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:34286483G>A	uc002xdw.1	-	2	191	c.127C>T	c.(127-129)CCC>TCC	p.P43S	NFS1_uc002xdt.1_5'UTR|NFS1_uc002xdu.1_5'UTR|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_5'UTR|NFS1_uc010zvl.1_Missense_Mutation_p.P43S|NFS1_uc002xdx.2_Missense_Mutation_p.P43S|ROMO1_uc002xdy.2_5'Flank|ROMO1_uc010gfm.2_5'Flank	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	43					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GTATCTGCGGGAACCGCAGAC	0.542													0	0	0	0.00499	0	15	54										A	34286483	G	A	34286483	3	1	16	1	0	0	0	0	1	0	0	0	10385	1174	41	1	1294	1	NFS1	20	34286483	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	4093269	34286483	28739037	663	4386										
PHF20	51230	broad.mit.edu	37	chr20	34459579	34459579	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttttttcttctaggtcagttGaagtctgctttggaagctgg	11	6	4	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:34459579G>A	uc002xek.1	+	9	1221	c.1110G>A	c.(1108-1110)TTG>TTA	p.L370L	PHF20_uc002xei.1_Silent_p.L370L|PHF20_uc010gfo.1_Silent_p.L370L|PHF20_uc002xej.1_Silent_p.L254L	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					TAGGTCAGTTGAAGTCTGCTT	0.453													0	0	0	0.01441	0	57	72										A	34459579	G	A	34459579	2	1	16	1	0	0	0	0	0	0	0	1	11831	1281	45	1		1	PHF20	20	34459579	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	173096	34459579	28565941	664	4387										
PPP1R16B	26051	broad.mit.edu	37	chr20	37547047	37547047	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagagccctcagacgcttcTggagctgaagcggcagcggg	15	12	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:37547047T>C	uc002xje.2	+	11	1631	c.1442T>C	c.(1441-1443)CTG>CCG	p.L481P	PPP1R16B_uc010ggc.2_Missense_Mutation_p.L439P	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	481					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGACGCTTCTGGAGCTGAAG	0.647													0	0	0	0.010818	0	31	50										C	37547047	T	C	37547047	3	2	16	1	0	0	0	0	1	0	0	0	12366	1580	55	5	1480	5	PPP1R16B	20	37547047	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	3087468	37547047	25478473	665	4388										
FAM83D	81610	broad.mit.edu	37	chr20	37570635	37570635	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcatggacgtgttcacagacAtcgacatcttcagagacctg	9	11	4	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:37570635A>G	uc002xjg.2	+	2	648	c.607A>G	c.(607-609)ATC>GTC	p.I203V	FAM83D_uc002xjf.2_Missense_Mutation_p.I203V	NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	173					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				GTTCACAGACATCGACATCTT	0.478													0	0	0	0.004656	0	25	58										G	37570635	A	G	37570635	3	3	16	1	0	0	0	0	1	0	0	0	5636	217	8	5	613	5	FAM83D	20	37570635	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	23588	37570635	25454885	666	4389										
SERINC3	10955	broad.mit.edu	37	chr20	43132519	43132519	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aattatctgaatccagtaaaGacccactctttgatggtgga	8	8	2	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:43132519G>A	uc002xme.2	-	8	1126	c.992C>T	c.(991-993)TCT>TTT	p.S331F	SERINC3_uc002xmf.1_Missense_Mutation_p.S331F|SERINC3_uc010ggs.1_Missense_Mutation_p.S324F|SERINC3_uc010zwp.1_Missense_Mutation_p.S276F	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	331	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			ATCCAGTAAAGACCCACTCTT	0.413													0	0	0	0.014323	0	23	40										A	43132519	G	A	43132519	3	1	16	1	0	0	0	0	1	0	0	0	14081	942	33	1	441	1	SERINC3	20	43132519	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5561884	43132519	19893001	667	4390										
CDH22	64405	broad.mit.edu	37	chr20	44803691	44803691	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggctcttgtggtggcgcctGagggtgaggatcagcagcac	17	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:44803691G>A	uc002xrm.2	-	11	2342	c.1941C>T	c.(1939-1941)CTC>CTT	p.L647L	CDH22_uc010ghk.1_Silent_p.L647L	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	647	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGTGGCGCCTGAGGGTGAGGA	0.627													0	0	0	0.004656	0	23	25										A	44803691	G	A	44803691	2	1	16	1	0	0	0	0	0	0	0	1	3107	1277	45	1		1	CDH22	20	44803691	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1671172	44803691	18221829	668	4391										
SULF2	55959	broad.mit.edu	37	chr20	46292924	46292924	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttgaggcggcctttgtgctgGgtgtggtagctgtaacagac	16	7	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:46292924G>C	uc002xto.2	-	15	2337	c.2007C>G	c.(2005-2007)ACC>ACG	p.T669T	SULF2_uc002xtr.2_Silent_p.T669T|SULF2_uc002xtq.2_Silent_p.T669T|SULF2_uc010zyd.1_5'UTR	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	669					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CTTTGTGCTGGGTGTGGTAGC	0.602											OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	8	25										C	46292924	G	C	46292924	2	2	16	1	0	0	0	0	0	0	0	1	15370	1219	43	4		4	SULF2	20	46292924	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1489233	46292924	16732596	669	4392										
ATP9A	10079	broad.mit.edu	37	chr20	50255994	50255994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gctgcatggaagactggtctCggcccaccagggttaagccc	13	13	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:50255994C>T	uc002xwg.1	-	15	1556	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	ATP9A_uc010gih.1_Missense_Mutation_p.R383Q|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	519	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						AGACTGGTCTCGGCCCACCAG	0.547											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	23	40										T	50255994	C	T	50255994	3	4	16	1	0	0	0	0	1	0	0	0	1198	884	31	1	1643	1	ATP9A	20	50255994	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3963070	50255994	12769526	670	4393										
SALL4	57167	broad.mit.edu	37	chr20	50400861	50400861	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggaaactggtgtttgggaacGccgtcagtagcacttggttt	14	7	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:50400861G>C	uc002xwh.3	-	4	3206	c.3105C>G	c.(3103-3105)GGC>GGG	p.G1035G	SALL4_uc010gii.2_Silent_p.G598G|SALL4_uc002xwi.3_Silent_p.G258G	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	1035					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTTTGGGAACGCCGTCAGTAG	0.517													0	0	0	0.014323	0	21	80										C	50400861	G	C	50400861	2	2	16	1	0	0	0	0	0	0	0	1	13813	1074	38	4		4	SALL4	20	50400861	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	144867	50400861	12624659	671	4394										
SLC17A9	63910	broad.mit.edu	37	chr20	61588228	61588228	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgagccaggacttcggctgGaacaagaaggaggccggcat	15	9	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:61588228G>A	uc002yea.3	+	2	355	c.171G>A	c.(169-171)TGG>TGA	p.W57*	SLC17A9_uc002ydz.3_Nonsense_Mutation_p.W51*|SLC17A9_uc011aap.1_Nonsense_Mutation_p.W77*	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	57					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						ACTTCGGCTGGAACAAGAAGG	0.632													0	0	0	0.006214	0	9	32										A	61588228	G	A	61588228	4	1	16	1	0	0	0	0	0	1	0	0	14424	1183	41	1	177	1	SLC17A9	20	61588228	Nonsense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	11187367	61588228	1437292	672	4395										
TPTE	7179	broad.mit.edu	37	chr21	10934121	10934121	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggatcgtaagctctttcacCtaaaataaataatatgtatg	6	6	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:10934121C>G	uc002yip.1	-	16	1225	c.857_splice	c.e16-1	p.S286_splice	TPTE_uc002yis.1_Splice_Site|TPTE_uc002yiq.1_Splice_Site_p.S268_splice|TPTE_uc002yir.1_Splice_Site_p.S248_splice|TPTE_uc010gkv.1_Splice_Site_p.S148_splice	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTCTTTCACCTAAAATAAAT	0.299													0	0	0	0.00278	0	22	163										G	10934121	C	G	10934121	5	3	16	1	0	0	0	0	0	0	1	0	16427	695	24	4	835	4	TPTE	21	10934121	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08		10934121	37195774	673	4396										
MRPL39	54148	broad.mit.edu	37	chr21	26978900	26978900	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctggctttctctttattaaaGagatcattccgcatttctgt	6	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:26978900G>C	uc002ylo.2	-	2	155	c.141C>G	c.(139-141)CTC>CTG	p.L47L	MRPL39_uc002yln.2_Silent_p.L47L	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	47						mitochondrial ribosome	nucleotide binding				0						CTTTATTAAAGAGATCATTCC	0.413													0	0	0	0.00308	0	7	48										C	26978900	G	C	26978900	2	2	16	1	0	0	0	0	0	0	0	1	9802	929	33	1		1	MRPL39	21	26978900	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	16044779	26978900	21150995	674	4397										
GRIK1	2897	broad.mit.edu	37	chr21	30959910	30959910	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccactgccaggtcagccctCtgcaaaagcaagtccaaaat	8	14	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:30959910C>G	uc002yno.1	-	12	2034	c.1570_splice	c.e12-1	p.R524_splice	GRIK1_uc002ynn.2_Splice_Site_p.R509_splice|GRIK1_uc011acs.1_Splice_Site_p.R524_splice|GRIK1_uc011act.1_Splice_Site_p.R385_splice|GRIK1_uc010glq.1_Splice_Site_p.R367_splice	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1						central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGTCAGCCCTCTGCAAAAGCA	0.453													0	0	0	0.00308	0	8	15										G	30959910	C	G	30959910	5	3	16	1	0	0	0	0	0	0	1	0	6773	927	32	1	1371	1	GRIK1	21	30959910	Splice_Site	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3981010	30959910	17169985	675	4398										
C21orf59	56683	broad.mit.edu	37	chr21	33979964	33979964	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttaaaaaagccaaccttagAtattattgctttggcttctt	5	7	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:33979964A>G	uc002yqc.2	-	3	483	c.370T>C	c.(370-372)TCT>CCT	p.S124P	C21orf59_uc002ypx.1_Missense_Mutation_p.S17P|C21orf59_uc002ypy.1_Missense_Mutation_p.S124P|C21orf59_uc002ypz.1_Missense_Mutation_p.S124P|C21orf59_uc010glx.2_Intron|C21orf59_uc002yqd.2_Missense_Mutation_p.S124P|C21orf59_uc002yqb.3_Missense_Mutation_p.S124P|C21orf59_uc011adr.1_Missense_Mutation_p.S68P	NM_021254	NP_067077	P57076	CU059_HUMAN	hypothetical protein LOC56683	124						cytosol|nucleus					0						CCAACCTTAGATATTATTGCT	0.249													0	0	0	0.00245	0	15	40										G	33979964	A	G	33979964	3	3	16	1	0	0	0	0	1	0	0	0	2130	333	12	5	522	5	C21orf59	21	33979964	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	3020054	33979964	14149931	676	4399										
SYNJ1	8867	broad.mit.edu	37	chr21	34003938	34003938	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acagaactcaaaacattactTtgcgttgcagaaggcaactg	8	9	1	2	rs61750219		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:34003938T>C	uc002yqh.2	-	32	4206	c.4206A>G	c.(4204-4206)CAA>CAG	p.Q1402Q	SYNJ1_uc011ads.1_3'UTR|SYNJ1_uc002yqf.2_3'UTR|SYNJ1_uc002yqg.2_Silent_p.Q1316Q|SYNJ1_uc002yqi.2_3'UTR|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1363	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						AAACATTACTTTGCGTTGCAG	0.448													0	0	0	0.013726	0	28	29										C	34003938	T	C	34003938	2	2	16	1	0	0	0	0	0	0	0	1	15449	1838	64	5		5	SYNJ1	21	34003938	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	23974	34003938	14125957	677	4400										
DOPEY2	9980	broad.mit.edu	37	chr21	37571421	37571421	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaagacggctcctcatcagCaaaagattagctcagtgttt	8	11	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:37571421C>T	uc002yvg.2	+	3	271	c.192C>T	c.(190-192)AGC>AGT	p.S64S	DOPEY2_uc011aeb.1_Silent_p.S64S	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	64					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCCTCATCAGCAAAAGATTAG	0.458													0	0	0	0.007413	0	19	43										T	37571421	C	T	37571421	2	4	16	1	0	0	0	0	0	0	0	1	4708	709	25	2		2	DOPEY2	21	37571421	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3567483	37571421	10558474	678	4401										
ZNF295	49854	broad.mit.edu	37	chr21	43413477	43413477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctctgtcttgcagaggctttGaaggcaacactgcatttctt	9	10	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:43413477G>A	uc002zab.3	-	3	942	c.728C>T	c.(727-729)TCA>TTA	p.S243L	ZNF295_uc002yzz.3_Missense_Mutation_p.S243L|ZNF295_uc002yzy.3_Missense_Mutation_p.S243L|ZNF295_uc002zaa.3_Missense_Mutation_p.S243L|ZNF295_uc010gov.1_Missense_Mutation_p.S243L|ZNF295_uc002zac.2_Missense_Mutation_p.S243L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	243					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CAGAGGCTTTGAAGGCAACAC	0.428													0	0	0	0.001855	0	14	17										A	43413477	G	A	43413477	3	1	16	1	0	0	0	0	1	0	0	0	17824	1294	45	1	2476	1	ZNF295	21	43413477	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5842056	43413477	4716418	679	4402										
TRAPPC10	7109	broad.mit.edu	37	chr21	45522807	45522807	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgcccgacgtcaggctgttCaagtacctcccccatcattc	7	17	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:45522807C>T	uc002zea.2	+	22	3664	c.3495C>T	c.(3493-3495)TTC>TTT	p.F1165F	TRAPPC10_uc010gpo.2_Silent_p.F876F|TRAPPC10_uc011afa.1_Silent_p.F543F	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1165					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TCAGGCTGTTCAAGTACCTCC	0.552													0	0	0	0.01441	0	41	75										T	45522807	C	T	45522807	2	4	16	1	0	0	0	0	0	0	0	1	16454	825	29	1		1	TRAPPC10	21	45522807	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2109330	45522807	2607088	680	4403										
POFUT2	23275	broad.mit.edu	37	chr21	46685469	46685469	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccgcagaacctgttgtacgtCgtcttggggtccaaccccag	11	14	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:46685469C>T	uc002zhc.2	-	9	1243	c.1218G>A	c.(1216-1218)ACG>ACA	p.T406T	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_3'UTR	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	406					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		TGTTGTACGTCGTCTTGGGGT	0.527													0	0	0	0.00245	0	14	55										T	46685469	C	T	46685469	2	4	16	1	0	0	0	0	0	0	0	1	12184	871	31	1		1	POFUT2	21	46685469	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1162662	46685469	1444426	681	4404										
MCM3AP	8888	broad.mit.edu	37	chr21	47704198	47704198	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgtccgaccaaataaagtacCtccccggggtcgattcaggc	10	14	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:47704198C>A	uc002zir.1	-	1	1039	c.1003G>T	c.(1003-1005)GGT>TGT	p.G335C	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	335					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					AATAAAGTACCTCCCCGGGGT	0.522													1	0	2.70662e-09	0.009535	2.86622e-09	33	124										A	47704198	C	A	47704198	3	1	16	1	0	0	0	0	1	0	0	0	9388	681	24	4	5051	4	MCM3AP	21	47704198	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1018729	47704198	425697	682	4405										
P2RX6	9127	broad.mit.edu	37	chr22	21380552	21380552	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctctcccaggtcacctttttCtgtgacctgctactgctgta	7	14	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:21380552C>T	uc010gsu.1	+	11	1062	c.1062C>T	c.(1060-1062)TTC>TTT	p.F354F	P2RX6_uc002ztz.2_Silent_p.F328F|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	354	Helical; Name=2; (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TCACCTTTTTCTGTGACCTGC	0.463													0	0	0	0.001984	0	6	7										T	21380552	C	T	21380552	2	4	16	1	0	0	0	0	0	0	0	1	11344	912	32	1		1	P2RX6	22	21380552	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08		21380552	29924014	683	4406										
CCDC116	164592	broad.mit.edu	37	chr22	21988323	21988323	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgctcaggtgcagctgcccAagaagccactggtcccagaa	11	14	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:21988323A>T	uc002zve.2	+	3	178	c.85A>T	c.(85-87)AAG>TAG	p.K29*	CCDC116_uc011aih.1_Nonsense_Mutation_p.K29*	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	29										ovary(1)|skin(1)	2	Colorectal(54;0.105)					GCAGCTGCCCAAGAAGCCACT	0.637													0	0	0	0.007291	0	28	75										T	21988323	A	T	21988323	4	4	16	1	0	0	0	0	0	1	0	0	2753	131	5	5	91	5	CCDC116	22	21988323	Nonsense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	607771	21988323	29316243	684	4407										
TOP3B	8940	broad.mit.edu	37	chr22	22322014	22322014	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tttgtcatgtttaaaaacatCtgtgcgatctcccggtcaaa	7	9	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:22322014C>T	uc002zvs.2	-	8	1248	c.813G>A	c.(811-813)CAG>CAA	p.Q271Q	TOP3B_uc010gtm.1_5'UTR|TOP3B_uc002zvr.2_5'UTR|TOP3B_uc010gtl.2_Silent_p.Q271Q|TOP3B_uc002zvt.3_Silent_p.Q271Q	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	271					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TTAAAAACATCTGTGCGATCT	0.502													0	0	0	0.003271	0	31	73										T	22322014	C	T	22322014	2	4	16	1	0	0	0	0	0	0	0	1	16365	912	32	1		1	TOP3B	22	22322014	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	333691	22322014	28982552	685	4408										
GGTLC2	91227	broad.mit.edu	37	chr22	22989480	22989480	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gccgctctcgtcaatgtgccCgacgatcatggtgggccagg	14	13	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:22989480C>T	uc010gtt.2	+	3	366	c.332C>T	c.(331-333)CCG>CTG	p.P111L	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Missense_Mutation_p.P111L	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	111					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		TCAATGTGCCCGACGATCATG	0.652													0	0	0	0.003755	0	32	91										T	22989480	C	T	22989480	3	4	16	1	0	0	0	0	1	0	0	0	6366	652	23	2	342	2	GGTLC2	22	22989480	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	667466	22989480	28315086	686	4409										
C22orf28	51493	broad.mit.edu	37	chr22	32797844	32797858	+	In_Frame_Del	DEL	GGTTCTTAGCAAGCG	GGTTCTTAGCAAGCG	-													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	acatcactttcatctaaattGgttcttagcaagcggacacc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:32797844_32797858delGGTTCTTAGCAAGCG	uc003amm.2	-	5	504_518	c.373_387delCGCTTGCTAAGAACC	c.(373-387)CGCTTGCTAAGAACCdel	p.RLLRT125del	C22orf28_uc011ama.1_RNA	NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	125_129					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0						CATCTAAATTGGTTCTTAGCAAGCGGACACCACAG	0.465																		10	36	---	---								-	32797858	GGTTCTTAGCAAGCG	-	32797844	7	5	16	1	0	1	0	1	0	0	0	0	2140	1335	47	0	1162	0	C22orf28	22	32797844	In_Frame_Del	DEL	GGTTCTTAGCAAGCG	TCGA-BT-A2LB-01A-11D-A18F-08	9808364	32797844	18506722	687	4410										
CARD10	29775	broad.mit.edu	37	chr22	37887821	37887821	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgacgatggggtagatctcGttctgcaccagctcccgcac	11	13	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:37887821G>C	uc003asx.1	-	19	2808	c.2805C>G	c.(2803-2805)AAC>AAG	p.N935K	CARD10_uc003ast.1_RNA|CARD10_uc003asu.1_5'UTR|CARD10_uc003asv.1_5'UTR|CARD10_uc011ank.1_Missense_Mutation_p.N253K|CARD10_uc003asw.1_Missense_Mutation_p.N649K|CARD10_uc003asy.1_Missense_Mutation_p.N935K	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	935					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GGTAGATCTCGTTCTGCACCA	0.617													0	0	0	0.006214	0	7	55										C	37887821	G	C	37887821	3	2	16	1	0	0	0	0	1	0	0	0	2644	1136	40	4	301	4	CARD10	22	37887821	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	5089977	37887821	13416745	688	4411										
GALR3	8484	broad.mit.edu	37	chr22	38220829	38220829	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggctgctggcggcgctcttCtcggcgccctacctcagcta	12	16	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:38220829C>G	uc003aub.1	+	2	484	c.459C>G	c.(457-459)TTC>TTG	p.F153L		NM_003614	NP_003605	O60755	GALR3_HUMAN	galanin receptor 3	153	Helical; Name=4; (Potential).				feeding behavior|learning or memory|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity				0	Melanoma(58;0.045)					CGGCGCTCTTCTCGGCGCCCT	0.771													0	0	0	0.000602	0	4	11										G	38220829	C	G	38220829	3	3	16	1	0	0	0	0	1	0	0	0	6229	912	32	1	465	1	GALR3	22	38220829	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	333008	38220829	13083737	689	4412										
PLA2G6	8398	broad.mit.edu	37	chr22	38541624	38541624	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaagaatactgatggaaattCactagggcgtcagcctccaa	10	9	2	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:38541624C>T	uc003auy.1	-	3	382	c.246G>A	c.(244-246)GTG>GTA	p.V82V	PLA2G6_uc003auz.1_Silent_p.V82V|PLA2G6_uc003ava.1_Silent_p.V82V|PLA2G6_uc003avb.2_Silent_p.V82V|PLA2G6_uc010gxk.1_Intron|PLA2G6_uc011ano.1_Silent_p.V82V	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	82					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	GATGGAAATTCACTAGGGCGT	0.572													0	0	0	0.007413	0	15	36										T	38541624	C	T	38541624	2	4	16	1	0	0	0	0	0	0	0	1	12008	813	29	1		1	PLA2G6	22	38541624	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	320795	38541624	12762942	690	4413										
NPTXR	23467	broad.mit.edu	37	chr22	39239400	39239400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cgcagcggcccagcttgccgGtgagctcacggatggtgtcc	15	14	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:39239400G>A	uc003awk.2	-	1	618	c.464C>T	c.(463-465)ACC>ATC	p.T155I		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	155	Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CAGCTTGCCGGTGAGCTCACG	0.602													0	0	0	0.004672	0	3	10										A	39239400	G	A	39239400	3	1	16	1	0	0	0	0	1	0	0	0	10604	1261	44	2	1058	2	NPTXR	22	39239400	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	697776	39239400	12065166	691	4414										
EP300	2033	broad.mit.edu	37	chr22	41513289	41513289	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtggtgatattaatcagcttCagacaagtcttggcatggta	11	6	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:41513289C>T	uc003azl.3	+	2	588	c.193C>T	c.(193-195)CAG>TAG	p.Q65*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	65	Interaction with ALX1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TAATCAGCTTCAGACAAGTCT	0.418			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.008871	0	19	43										T	41513289	C	T	41513289	4	4	16	1	0	0	0	0	0	1	0	0	5148	827	29	1	199	1	EP300	22	41513289	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2273889	41513289	9791277	692	4415										
TCF20	6942	broad.mit.edu	37	chr22	42607770	42607770	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aggattcttgtaacttctggGagccatgctttaattccatg	9	8	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:42607770G>A	uc003bcj.1	-	1	3676	c.3542C>T	c.(3541-3543)TCC>TTC	p.S1181F	TCF20_uc003bck.1_Missense_Mutation_p.S1181F|TCF20_uc003bnt.2_Missense_Mutation_p.S1181F	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1181	Leucine-zipper.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TAACTTCTGGGAGCCATGCTT	0.532													0	0	0	0.010504	0	22	59										A	42607770	G	A	42607770	3	1	16	1	0	0	0	0	1	0	0	0	15687	1174	41	1	2378	1	TCF20	22	42607770	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1094481	42607770	8696796	693	4416										
TTLL12	23170	broad.mit.edu	37	chr22	43570524	43570524	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cctgtagtccttgaagtgtgAgaagttgaagaggatgtcgg	15	5	0	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:43570524A>C	uc003bdq.2	-	7	1047	c.1015T>G	c.(1015-1017)TCA>GCA	p.S339A	TTLL12_uc003bdr.1_Missense_Mutation_p.S339A	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	339	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				TTGAAGTGTGAGAAGTTGAAG	0.657													0	0	0	0.010818	0	28	46										C	43570524	A	C	43570524	3	2	16	1	0	0	0	0	1	0	0	0	16722	304	11	5	951	5	TTLL12	22	43570524	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	962754	43570524	7734042	694	4417										
IL17REL	400935	broad.mit.edu	37	chr22	50436125	50436125	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agaacttacttgggaagcgaCgctgttcgaaagggcaccgc	13	10	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:50436125C>T	uc003bje.1	-	12	1098	c.866G>A	c.(865-867)CGT>CAT	p.R289H		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	289										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TGGGAAGCGACGCTGTTCGAA	0.527													0	0	0	0.003163	0	13	49										T	50436125	C	T	50436125	3	4	16	1	0	0	0	0	1	0	0	0	7644	536	19	2	156	2	IL17REL	22	50436125	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6865601	50436125	868441	695	4418										
PANX2	56666	broad.mit.edu	37	chr22	50609337	50609337	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tggtcaccatcggcaccgtgCtggtgcccatcctgctggtc	12	15	1	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:50609337C>T	uc003bjn.3	+	1	178	c.178C>T	c.(178-180)CTG>TTG	p.L60L	PANX2_uc003bjp.3_5'UTR|PANX2_uc003bjo.3_Silent_p.L60L	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	60	Helical; (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CGGCACCGTGCTGGTGCCCAT	0.587													0	0	0	0.000602	0	4	12										T	50609337	C	T	50609337	2	4	16	1	0	0	0	0	0	0	0	1	11421	796	28	2		2	PANX2	22	50609337	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	173212	50609337	695229	696	4419										
PLXNB2	23654	broad.mit.edu	37	chr22	50719219	50719220	+	Frame_Shift_Ins	INS	-	-	G													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caggttggagaactggtagaINSgggcctgctccaccaccggc							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:50719219_50719220insG	uc003bkv.3	-	24	4052_4053	c.3946_3947insC	c.(3946-3948)CTCfs	p.L1316fs	PLXNB2_uc003bkt.1_Frame_Shift_Ins_p.L108fs|PLXNB2_uc003bku.1_Frame_Shift_Ins_p.L301fs	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1316	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAACTGGTAGAGGGCCTGCTCC	0.653																		9	36	---	---								G	50719220	-	G	50719219	7	5	16	1	0	1	1	0	0	0	0	0	12124	304	11	0	1625	0	PLXNB2	22	50719219	Frame_Shift_Ins	INS	-	TCGA-BT-A2LB-01A-11D-A18F-08	109882	50719219	585347	697	4420										
SLC25A6	293	broad.mit.edu	37	chrX	1505571	1505571	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cccgcaggacgttggaccacGcacccttgaagaaggccttg	12	14	0	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:1505571G>T	uc004cpt.2	-	4	917	c.821C>A	c.(820-822)GCG>GAG	p.A274E	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	274	Helical; Name=6; (By similarity).|Solcar 3.				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GTTGGACCACGCACCCTTGAA	0.607													1	0	1.19662e-71	0.01441	1.30239e-71	154	78										T	1505571	G	T	1505571	3	4	16	1	0	0	0	0	1	0	0	0	14513	1087	38	4	79	4	SLC25A6	23	1505571	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08		1505571	153764989	698	4421										
ARSH	347527	broad.mit.edu	37	chrX	2945385	2945385	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atgggaggatgggaaggaggTatccgtgtgccagggatatt	18	4	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:2945385T>C	uc011mhj.1	+	7	1068	c.1068T>C	c.(1066-1068)GGT>GGC	p.G356G		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	356						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GGGAAGGAGGTATCCGTGTGC	0.453													0	0	0	0.00623	0	36	20										C	2945385	T	C	2945385	2	2	16	1	0	0	0	0	0	0	0	1	993	1625	57	5		5	ARSH	23	2945385	Silent	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	1439814	2945385	152325175	699	4422										
MID1	4281	broad.mit.edu	37	chrX	10535150	10535150	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ttattcgggtgagtggctttCaggcactcgtcacagtagga	13	8	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:10535150C>T	uc004cte.3	-	2	629	c.438G>A	c.(436-438)CTG>CTA	p.L146L	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Silent_p.L146L|MID1_uc004cth.3_Silent_p.L146L|MID1_uc004ctk.3_Silent_p.L146L|MID1_uc004cti.3_Silent_p.L146L|MID1_uc004ctj.3_Silent_p.L146L|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Silent_p.L146L|MID1_uc004ctn.1_Silent_p.L146L|MID1_uc004cto.1_Silent_p.L146L|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Silent_p.L146L|MID1_uc004ctu.2_Silent_p.L146L|MID1_uc004ctv.2_Silent_p.L146L|MID1_uc004ctw.2_Silent_p.L146L|MID1_uc010ndy.1_Silent_p.L146L|uc010ndz.1_5'Flank|MID1_uc004cty.2_Silent_p.L146L|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Silent_p.L146L|MID1_uc010nea.1_Intron|MID1_uc004cuc.1_Silent_p.L146L|MID1_uc004cud.1_Silent_p.L146L|MID1_uc004cue.1_Silent_p.L146L|MID1_uc004cuf.1_Silent_p.L146L|MID1_uc004cug.1_Silent_p.L146L	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	146	B box-type 1.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						GAGTGGCTTTCAGGCACTCGT	0.552													0	0	0	0.004289	0	38	24										T	10535150	C	T	10535150	2	4	16	1	0	0	0	0	0	0	0	1	9576	813	29	1		1	MID1	23	10535150	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	7589765	10535150	144735410	700	4423										
ARHGAP6	395	broad.mit.edu	37	chrX	11204418	11204418	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggacctgtctgtaaataggaTtcagactgagtttcttatct	9	7	4	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:11204418T>C	uc004cup.1	-	5	2084	c.1211A>G	c.(1210-1212)AAT>AGT	p.N404S	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.N404S|ARHGAP6_uc004cum.1_Missense_Mutation_p.N201S|ARHGAP6_uc004cun.1_Missense_Mutation_p.N224S|ARHGAP6_uc010neb.1_Missense_Mutation_p.N226S|ARHGAP6_uc011mif.1_Missense_Mutation_p.N201S	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	404	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GTAAATAGGATTCAGACTGAG	0.428													0	0	0	0.01441	0	110	84										C	11204418	T	C	11204418	3	2	16	1	0	0	0	0	1	0	0	0	887	1493	52	5	1871	5	ARHGAP6	23	11204418	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	669268	11204418	144066142	701	4424										
AMELX	265	broad.mit.edu	37	chrX	11316858	11316858	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccaacactccatgactccaaTccaacaccaccagccaaacc	2	20	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:11316858T>C	uc004cut.2	+	5	403	c.335T>C	c.(334-336)ATC>ACC	p.I112T	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.I126T|AMELX_uc004cuu.2_Missense_Mutation_p.I96T	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	112					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						ATGACTCCAATCCAACACCAC	0.642													0	0	0	0.01441	0	65	39										C	11316858	T	C	11316858	3	2	16	1	0	0	0	0	1	0	0	0	569	1435	50	5	395	5	AMELX	23	11316858	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	112440	11316858	143953702	702	4425										
RBBP7	5931	broad.mit.edu	37	chrX	16864054	16864054	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcttagcagtgtgtcctccaTgaataaactgttacaagaac	7	9	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:16864054T>A	uc004cxt.2	-	11	1464	c.1106A>T	c.(1105-1107)CAT>CTT	p.H369L	RBBP7_uc004cxs.1_Missense_Mutation_p.H413L|RBBP7_uc004cxu.2_Missense_Mutation_p.H360L	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	369	WD 6.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					GTGTCCTCCATGAATAAACTG	0.363													0	0	0	0.007291	0	31	19										A	16864054	T	A	16864054	3	1	16	1	0	0	0	0	1	0	0	0	13104	1464	51	5	179	5	RBBP7	23	16864054	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	5547196	16864054	138406506	703	4426										
DMD	1756	broad.mit.edu	37	chrX	31947824	31947824	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccagtttcatttaattgtttGagaattccctggcgcagggg	11	8	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:31947824G>C	uc004dda.1	-	47	7045	c.6801C>G	c.(6799-6801)CTC>CTG	p.L2267L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Silent_p.L923L|DMD_uc004dcx.2_Silent_p.L926L|DMD_uc004dcz.2_Silent_p.L2144L|DMD_uc004dcy.1_Silent_p.L2263L|DMD_uc004ddb.1_Silent_p.L2259L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2267	Spectrin 16.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTAATTGTTTGAGAATTCCCT	0.423													0	0	0	0.012319	0	21	31										C	31947824	G	C	31947824	2	2	16	1	0	0	0	0	0	0	0	1	4580	1277	45	1		1	DMD	23	31947824	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	15083770	31947824	123322736	704	4427										
USP9X	8239	broad.mit.edu	37	chrX	41047370	41047371	+	Splice_Site	INS	-	-	GT													0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tcactaaaatttatgagaagINSgtaagaattatcacagaact							TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:41047370_41047371insGT	uc004dfb.2	+	25	4443	c.3810_splice	c.e25+1	p.K1270_splice	USP9X_uc004dfc.2_Splice_Site_p.K1270_splice	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTTATGAGAAGGTAAGAATTAT	0.297																		19	15	---	---								GT	41047371	-	GT	41047370	8	5	16	1	0	1	1	0	0	0	1	0	17087	1014	35	0	3904	0	USP9X	23	41047370	Splice_Site	INS	-	TCGA-BT-A2LB-01A-11D-A18F-08	9099546	41047370	114223190	705	4428										
KDM6A	7403	broad.mit.edu	37	chrX	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ccagagtgcctagcgtctctCagcctggagtccgtcctgcc	11	16	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.007291	0	29	24										T	44922802	C	T	44922802	4	4	16	1	0	0	0	0	0	1	0	0	8137	827	29	1	1725	1	KDM6A	23	44922802	Nonsense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	3875432	44922802	110347758	706	4429										
CHST7	56548	broad.mit.edu	37	chrX	46434113	46434113	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aagtacccggtggtggtcatCaaggacgtgcgcctgctcga	14	11	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:46434113C>T	uc004dgt.2	+	1	922	c.747C>T	c.(745-747)ATC>ATT	p.I249I		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	249	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						TGGTGGTCATCAAGGACGTGC	0.682													0	0	0	0.010729	0	12	14										T	46434113	C	T	46434113	2	4	16	1	0	0	0	0	0	0	0	1	3409	816	29	1		1	CHST7	23	46434113	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1511311	46434113	108836447	707	4430										
OTUD5	55593	broad.mit.edu	37	chrX	48780496	48780496	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctgtgcactttgtttttcttCatactgtctaggtattcctg	7	9	3	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:48780496C>T	uc004dlu.2	-	9	1732	c.1671G>A	c.(1669-1671)ATG>ATA	p.M557I	OTUD5_uc004dlt.3_Missense_Mutation_p.M552I|OTUD5_uc004dlv.2_Missense_Mutation_p.M552I|OTUD5_uc011mmp.1_Missense_Mutation_p.M335I	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	557					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						TGTTTTTCTTCATACTGTCTA	0.532													0	0	0	0.003271	0	33	26										T	48780496	C	T	48780496	3	4	16	1	0	0	0	0	1	0	0	0	11315	826	29	1	48	1	OTUD5	23	48780496	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	2346383	48780496	106490064	708	4431										
GPKOW	27238	broad.mit.edu	37	chrX	48973498	48973498	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	aaccatggcccgaacattgtCaggatcaaggccttccacct	8	14	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:48973498C>T	uc004dmr.2	-	6	806	c.799G>A	c.(799-801)GAC>AAC	p.D267N		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	267	KOW 1.					nucleus	nucleic acid binding			ovary(2)	2						CGAACATTGTCAGGATCAAGG	0.547													0	0	0	0.004878	0	36	23										T	48973498	C	T	48973498	3	4	16	1	0	0	0	0	1	0	0	0	6613	826	29	1	655	1	GPKOW	23	48973498	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	193002	48973498	106297062	709	4432										
IQSEC2	23096	broad.mit.edu	37	chrX	53268459	53268459	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtcaccaagatcttcttcttCtggaaaattttggtgacctt	7	9	5	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:53268459C>A	uc004dsd.2	-	11	3234	c.3033G>T	c.(3031-3033)CAG>CAT	p.Q1011H	IQSEC2_uc004dsc.2_Missense_Mutation_p.Q806H	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	1001	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						TCTTCTTCTTCTGGAAAATTT	0.498											OREG0019800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.000308642	0.003163	0.000319004	14	27										A	53268459	C	A	53268459	3	1	16	1	0	0	0	0	1	0	0	0	7818	912	32	3	1453	3	IQSEC2	23	53268459	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	4294961	53268459	102002101	710	4433										
PFKFB1	5207	broad.mit.edu	37	chrX	54959877	54959877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	atccagggcttcctcaggttCccgggtgatgtccacattct	10	13	2	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:54959877C>T	uc004dty.1	-	14	1446	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	PFKFB1_uc010nkd.1_Missense_Mutation_p.E267K|PFKFB1_uc011mol.1_Missense_Mutation_p.E394K	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	459	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TCCTCAGGTTCCCGGGTGATG	0.552													0	0	0	0.004656	0	27	16										T	54959877	C	T	54959877	3	4	16	1	0	0	0	0	1	0	0	0	11760	864	30	1	44	1	PFKFB1	23	54959877	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	1691418	54959877	100310683	711	4434										
APEX2	27301	broad.mit.edu	37	chrX	55028739	55028739	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtggctgctgaagaaggcctGagtggcctgtttgccaccca	14	11	0	3			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:55028739G>A	uc004dtz.2	+	3	373	c.297G>A	c.(295-297)CTG>CTA	p.L99L	APEX2_uc011mom.1_Intron	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	99					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						AAGAAGGCCTGAGTGGCCTGT	0.552								Other_BER_factors					0	0	0	0.01441	0	46	20										A	55028739	G	A	55028739	2	1	16	1	0	0	0	0	0	0	0	1	770	1277	45	1		1	APEX2	23	55028739	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	68862	55028739	100241821	712	4435										
UBQLN2	29978	broad.mit.edu	37	chrX	56591246	56591246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	cttcccgcacagaaaatcgcGatccactacccaatccatgg	6	16	0	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:56591246G>A	uc004dus.2	+	1	1175	c.940G>A	c.(940-942)GAT>AAT	p.D314N	UBQLN2_uc011moq.1_Missense_Mutation_p.D314N	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	314						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						AGAAAATCGCGATCCACTACC	0.567													0	0	0	0.005443	0	27	20										A	56591246	G	A	56591246	3	1	16	1	0	0	0	0	1	0	0	0	16894	1058	37	1	942	1	UBQLN2	23	56591246	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1562507	56591246	98679314	713	4436										
KIAA2022	340533	broad.mit.edu	37	chrX	73963126	73963126	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	agatggccctgctttggattCttaagttgctctacttcagt	9	9	3	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:73963126C>T	uc004eby.2	-	3	1883	c.1266G>A	c.(1264-1266)AAG>AAA	p.K422K		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	422					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCTTTGGATTCTTAAGTTGCT	0.428													0	0	0	0.014323	0	21	39										T	73963126	C	T	73963126	2	4	16	1	0	0	0	0	0	0	0	1	8269	912	32	1		1	KIAA2022	23	73963126	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	17371880	73963126	81307434	714	4437										
MAGEE2	139599	broad.mit.edu	37	chrX	75003930	75003930	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgacactaatagccaactgGaccaaatcatttgccttatc	6	11	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:75003930G>A	uc004ecj.1	-	1	1142	c.957C>T	c.(955-957)GTC>GTT	p.V319V		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	319	MAGE 2.									ovary(1)|skin(1)	2						TAGCCAACTGGACCAAATCAT	0.453													0	0	0	0.012319	0	18	35										A	75003930	G	A	75003930	2	1	16	1	0	0	0	0	0	0	0	1	9186	1161	41	1		1	MAGEE2	23	75003930	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	1040804	75003930	80266630	715	4438										
TNMD	64102	broad.mit.edu	37	chrX	99854576	99854576	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	tgtatttactgccgtcgaggCaaccgctattgccgccgcgt	11	13	0	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:99854576C>T	uc004efy.3	+	7	1042	c.816C>T	c.(814-816)GGC>GGT	p.G272G	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	272	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						GCCGTCGAGGCAACCGCTATT	0.478													0	0	0	0.001984	0	5	16										T	99854576	C	T	99854576	2	4	16	1	0	0	0	0	0	0	0	1	16319	697	25	2		2	TNMD	23	99854576	Silent	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	24850646	99854576	55415984	716	4439										
TSPAN6	7105	broad.mit.edu	37	chrX	99888412	99888412	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ggcaccttacttcattgtttActttgtctgcatctctctgt	6	11	4	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:99888412A>T	uc004ega.1	-	5	678	c.575T>A	c.(574-576)GTA>GAA	p.V192E	TSPAN6_uc010nna.1_Missense_Mutation_p.V98E	NM_003270	NP_003261	O43657	TSN6_HUMAN	transmembrane 4 superfamily member 6	192	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			ovary(1)	1						TTCATTGTTTACTTTGTCTGC	0.294													0	0	0	0.004007	0	14	32										T	99888412	A	T	99888412	3	4	16	1	0	0	0	0	1	0	0	0	16648	391	14	5	174	5	TSPAN6	23	99888412	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	33836	99888412	55382148	717	4440										
MORC4	79710	broad.mit.edu	37	chrX	106219839	106219839	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	ctccttggtatactcaaagtCttgtttgttgtaggcaggtt	10	7	2	0			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:106219839C>T	uc004emu.3	-	9	1375	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.D378N|MORC4_uc004emw.3_Missense_Mutation_p.D126N	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	378							ATP binding|zinc ion binding			ovary(1)	1						TACTCAAAGTCTTGTTTGTTG	0.408													0	0	0	0.003163	0	13	43										T	106219839	C	T	106219839	3	4	16	1	0	0	0	0	1	0	0	0	9704	913	32	1	1717	1	MORC4	23	106219839	Missense_Mutation	SNP	C	TCGA-BT-A2LB-01A-11D-A18F-08	6331427	106219839	49050721	718	4441										
MID2	11043	broad.mit.edu	37	chrX	107084505	107084505	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	accatgagaatgagaaagtgAacatgtactgtgtatctgat	10	5	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:107084505A>G	uc004enl.2	+	2	1183	c.610A>G	c.(610-612)AAC>GAC	p.N204D	MID2_uc004enk.2_Missense_Mutation_p.N204D	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	204	B box-type 2.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGAGAAAGTGAACATGTACTG	0.507													0	0	0	0.00333	0	25	39										G	107084505	A	G	107084505	3	3	16	1	0	0	0	0	1	0	0	0	9578	246	9	5	616	5	MID2	23	107084505	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	864666	107084505	48186055	719	4442										
WDR44	54521	broad.mit.edu	37	chrX	117543582	117543582	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	caatatgcgaatgaaatacaAtactgaaggtatttttcatc	6	6	1	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:117543582A>G	uc004eqn.2	+	11	2089	c.1664A>G	c.(1663-1665)AAT>AGT	p.N555S	WDR44_uc004eqo.2_Missense_Mutation_p.N555S|WDR44_uc011mtr.1_Missense_Mutation_p.N530S|WDR44_uc010nqi.2_Missense_Mutation_p.N265S	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	555						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						ATGAAATACAATACTGAAGGT	0.348													0	0	0	0.007413	0	19	41										G	117543582	A	G	117543582	3	3	16	1	0	0	0	0	1	0	0	0	17293	101	4	5	1706	5	WDR44	23	117543582	Missense_Mutation	SNP	A	TCGA-BT-A2LB-01A-11D-A18F-08	10459077	117543582	37726978	720	4443										
ZCCHC12	170261	broad.mit.edu	37	chrX	117960326	117960326	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gcccaggtttttgagaatttGatcatcactctccaggagct	9	10	3	2			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:117960326G>A	uc004equ.2	+	4	1592	c.1119G>A	c.(1117-1119)TTG>TTA	p.L373L		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						TTGAGAATTTGATCATCACTC	0.502													0	0	0	0.00499	0	16	26										A	117960326	G	A	117960326	2	1	16	1	0	0	0	0	0	0	0	1	17578	1281	45	1		1	ZCCHC12	23	117960326	Silent	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	416744	117960326	37310234	721	4444										
SASH3	54440	broad.mit.edu	37	chrX	128922525	128922525	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gaacaggaagatgggcaagaTgatggtgaaggccctgtcag	16	6	1	4			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:128922525T>C	uc011mun.1	+	3	454	c.272T>C	c.(271-273)ATG>ACG	p.M91T	SASH3_uc004euu.2_Missense_Mutation_p.M91T|SASH3_uc011muo.1_Missense_Mutation_p.M8T	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	91										ovary(2)|pancreas(1)	3						ATGGGCAAGATGATGGTGAAG	0.572													0	0	0	0.003163	0	11	23										C	128922525	T	C	128922525	3	2	16	1	0	0	0	0	1	0	0	0	13849	1464	51	5	282	5	SASH3	23	128922525	Missense_Mutation	SNP	T	TCGA-BT-A2LB-01A-11D-A18F-08	10962199	128922525	26348035	722	4445										
MAGEA11	4110	broad.mit.edu	37	chrX	148797576	148797576	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32871012482663	237	1.44013991078056e-70	3.49331056509119	3.63236105426136	3.46474326162306	9.47726161769807e-46	6.16022005150375e-44	169	gtgcacaggctctccaagctGaggagcaggaggctgccttc	14	12	1	1			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:148797576G>A	uc004fdq.2	+	5	532	c.430G>A	c.(430-432)GAG>AAG	p.E144K	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.E115K	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	144						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TCTCCAAGCTGAGGAGCAGGA	0.577													0	0	0	0.008291	0	10	28										A	148797576	G	A	148797576	3	1	16	1	0	0	0	0	1	0	0	0	9165	1291	45	1	457	1	MAGEA11	23	148797576	Missense_Mutation	SNP	G	TCGA-BT-A2LB-01A-11D-A18F-08	19875051	148797576	6472984	723	4446										
NOL9	79707	broad.mit.edu	37	chr1	6585956	6585956	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ttaggtcttcggtatggtttCtctttatgtgcctcctcagg	10	9	3	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:6585956C>T	uc001ans.2	-	12	2086	c.2067G>A	c.(2065-2067)GAG>GAA	p.E689E	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	689					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		GGTATGGTTTCTCTTTATGTG	0.413													0	0	0	0.006214	0	8	81										T	6585956	C	T	6585956	2	4	17	1	0	0	0	0	0	0	0	1	10528	912	32	1		1	NOL9	1	6585956	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		6585956	242664665	1	4447										
ARID1A	8289	broad.mit.edu	37	chr1	27057789	27057790	+	Frame_Shift_Ins	INS	-	-	T													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cccctcatgcccaaccttcgINStatcagcagcagccacagtc							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:27057789_27057790insT	uc001bmv.1	+	3	1870_1871	c.1497_1498insT	c.(1495-1500)TCGTATfs	p.S499fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.S499fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.S499fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.S116fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	499_500					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCAACCTTCGTATCAGCAGCA	0.604			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													240	357	---	---								T	27057790	-	T	27057789	7	5	17	1	0	1	1	0	0	0	0	0	913	1132	40	0	1507	0	ARID1A	1	27057789	Frame_Shift_Ins	INS	-	TCGA-BT-A2LD-01A-12D-A20D-08	20471833	27057789	222192832	2	4448										
DMRTB1	63948	broad.mit.edu	37	chr1	53927213	53927213	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctggtggctccagcatgcaCccctactgcccgttcccgct	9	19	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:53927213C>A	uc001cvq.1	+	2	700	c.645C>A	c.(643-645)CAC>CAA	p.H215Q		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	215	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCAGCATGCACCCCTACTGCC	0.647													1	0	1.15088e-07	0.028581	1.29369e-07	16	146										A	53927213	C	A	53927213	3	1	17	1	0	0	0	0	1	0	0	0	4590	506	18	4	651	4	DMRTB1	1	53927213	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	26869424	53927213	195323408	3	4449										
ACOT11	26027	broad.mit.edu	37	chr1	55060253	55060253	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	agctgaagcagatcacgccgCggacagaagaggagaagatg	15	8	1	6			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:55060253C>T	uc001cxm.1	+	6	578	c.496C>T	c.(496-498)CGG>TGG	p.R166W	ACOT11_uc001cxj.1_Missense_Mutation_p.R44W|ACOT11_uc001cxk.2_Missense_Mutation_p.R132W|ACOT11_uc001cxl.1_Missense_Mutation_p.R166W	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	166					fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						GATCACGCCGCGGACAGAAGA	0.627													0	0	0	0.014758	0	4	44										T	55060253	C	T	55060253	3	4	17	1	0	0	0	0	1	0	0	0	149	759	27	2	518	2	ACOT11	1	55060253	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	1133040	55060253	194190368	4	4450										
TRIM46	80128	broad.mit.edu	37	chr1	155154564	155154564	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctacttggtcaaggtgggcGtcgggctggagagcaagctt	16	9	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:155154564G>A	uc001fhs.1	+	9	1908	c.1825G>A	c.(1825-1827)GTC>ATC	p.V609I	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.V483I|TRIM46_uc001fhu.1_Missense_Mutation_p.V586I|TRIM46_uc009wpg.1_Missense_Mutation_p.V596I|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	609	B30.2/SPRY.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CAAGGTGGGCGTCGGGCTGGA	0.647													0	0	0	0.020292	0	14	37										A	155154564	G	A	155154564	3	1	17	1	0	0	0	0	1	0	0	0	16518	1145	40	2	1859	2	TRIM46	1	155154564	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	100094311	155154564	94096057	5	4451										
NR1I3	9970	broad.mit.edu	37	chr1	161200969	161200969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gctcttggagctgcagttttCgtagtgttccatggaagtga	13	7	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:161200969C>T	uc001fzx.2	-	7	964	c.761G>A	c.(760-762)CGA>CAA	p.R254Q	TOMM40L_uc009wuf.1_Intron|NR1I3_uc001fzf.2_Missense_Mutation_p.R250Q|NR1I3_uc001fzg.2_Missense_Mutation_p.R221Q|NR1I3_uc001fzh.2_Missense_Mutation_p.R221Q|NR1I3_uc001fzi.2_Missense_Mutation_p.R221Q|NR1I3_uc001fzj.2_Missense_Mutation_p.R221Q|NR1I3_uc001fzk.2_Intron|NR1I3_uc001fzl.2_Intron|NR1I3_uc001fzm.2_Missense_Mutation_p.R175Q|NR1I3_uc001fzn.2_Intron|NR1I3_uc009wug.2_Missense_Mutation_p.R83Q|NR1I3_uc001fzp.2_Missense_Mutation_p.R254Q|NR1I3_uc001fzo.2_Missense_Mutation_p.R83Q|NR1I3_uc001fzq.2_Intron|NR1I3_uc001fzr.2_Intron|NR1I3_uc001fzs.2_Intron|NR1I3_uc001fzt.2_Intron|NR1I3_uc001fzu.2_Intron|NR1I3_uc001fzv.2_Intron|NR1I3_uc001fzw.2_Missense_Mutation_p.R254Q|NR1I3_uc001fzy.2_Missense_Mutation_p.R250Q|NR1I3_uc001fzz.2_Intron|NR1I3_uc001gaa.2_Intron|NR1I3_uc001gab.2_Intron|NR1I3_uc001gac.2_Missense_Mutation_p.R225Q|NR1I3_uc010pkm.1_Missense_Mutation_p.R221Q|NR1I3_uc010pkn.1_3'UTR	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2	254					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CTGCAGTTTTCGTAGTGTTCC	0.532													0	0	0	0.006122	0	17	29										T	161200969	C	T	161200969	3	4	17	1	0	0	0	0	1	0	0	0	10621	884	31	1	419	1	NR1I3	1	161200969	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	6046405	161200969	88049652	6	4452										
BAT2L2	23215	broad.mit.edu	37	chr1	171484973	171484973	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acaaatgatgacaactatggAcctggacccagtttacgtcc	8	11	0	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:171484973A>G	uc010pmg.1	+	5	761	c.495A>G	c.(493-495)GGA>GGG	p.G165G	BAT2L2_uc001ghq.1_Silent_p.G162G|BAT2L2_uc001ghr.1_Silent_p.G167G	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	165							protein C-terminus binding				0						ACAACTATGGACCTGGACCCA	0.398													0	0	0	0.006214	0	8	42										G	171484973	A	G	171484973	2	3	17	1	0	0	0	0	0	0	0	1	1321	262	10	5		5	BAT2L2	1	171484973	Silent	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	10284004	171484973	77765648	7	4453										
HMCN1	83872	broad.mit.edu	37	chr1	185953314	185953314	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctttaagttgctccaaaatcCttacatcactgtgcgcagtg	7	11	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:185953314C>T	uc001grq.1	+	19	3033	c.2804C>T	c.(2803-2805)CCT>CTT	p.P935L	HMCN1_uc001grr.1_Missense_Mutation_p.P276L	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	935	Ig-like C2-type 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CTCCAAAATCCTTACATCACT	0.383													0	0	0	0.006214	0	10	49										T	185953314	C	T	185953314	3	4	17	1	0	0	0	0	1	0	0	0	7220	681	24	2	2878	2	HMCN1	1	185953314	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	14468341	185953314	63297307	8	4454										
GPR37L1	9283	broad.mit.edu	37	chr1	202097242	202097242	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccagctggtgacatggcgggTgcgaggccctccagggagga	18	11	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:202097242T>G	uc001gxj.2	+	2	1067	c.1004T>G	c.(1003-1005)GTG>GGG	p.V335G		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	335	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						ACATGGCGGGTGCGAGGCCCT	0.617													0	0	0	0.016522	0	7	70										G	202097242	T	G	202097242	3	3	17	1	0	0	0	0	1	0	0	0	6692	1696	59	5	1010	5	GPR37L1	1	202097242	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	16143928	202097242	47153379	9	4455										
KCNH1	3756	broad.mit.edu	37	chr1	210856624	210856624	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ttttttttaaatagacctctCagctggctccaaaaatgtct	5	9	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:210856624C>T	uc001hib.2	-	11	3139	c.2969G>A	c.(2968-2970)TGA>TAA	p.*990*	KCNH1_uc001hic.2_Silent_p.*963*	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	990					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ATAGACCTCTCAGCTGGCTCC	0.443													0	0	0	0.010729	0	10	177										T	210856624	C	T	210856624	2	4	17	1	0	0	0	0	0	0	0	1	8031	837	29	1		1	KCNH1	1	210856624	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	8759382	210856624	38393997	10	4456										
FAM71A	149647	broad.mit.edu	37	chr1	212798487	212798487	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cagatgtcatgctactggcaCgaccggccaccggctgcgaa	12	14	1	1	rs141642686	byFrequency	TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:212798487C>T	uc001hjk.2	+	1	672	c.268C>T	c.(268-270)CGA>TGA	p.R90*	uc010pth.1_Intron	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	90										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		GCTACTGGCACGACCGGCCAC	0.567													0	0	0	0.00308	0	8	72										T	212798487	C	T	212798487	4	4	17	1	0	0	0	0	0	1	0	0	5607	528	19	2	270	2	FAM71A	1	212798487	Nonsense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	1941863	212798487	36452134	11	4457										
HHIPL2	79802	broad.mit.edu	37	chr1	222713516	222713516	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctggcgcgtgatggggtccCctcggtccacagcacaacgc	13	16	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:222713516C>T	uc001hnh.1	-	4	1344	c.1286G>A	c.(1285-1287)GGG>GAG	p.G429E		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	429					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GATGGGGTCCCCTCGGTCCAC	0.577													0	0	0	0.02938	0	7	94										T	222713516	C	T	222713516	3	4	17	1	0	0	0	0	1	0	0	0	7094	623	22	2	912	2	HHIPL2	1	222713516	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	9915029	222713516	26537105	12	4458										
RYR2	6262	broad.mit.edu	37	chr1	237787085	237787085	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	atcaatatgcttctcaatttTaaggatgacaaaagtgaatg	7	5	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr1:237787085T>G	uc001hyl.1	+	39	6057	c.5937T>G	c.(5935-5937)TTT>TTG	p.F1979L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1979	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCTCAATTTTAAGGATGACA	0.348													0	0	0	0.004672	0	3	26										G	237787085	T	G	237787085	3	3	17	1	0	0	0	0	1	0	0	0	13769	1751	61	5	6091	5	RYR2	1	237787085	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	15073569	237787085	11463536	13	4459										
PROKR1	10887	broad.mit.edu	37	chr2	68882436	68882436	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gggcgcccttctacggcttcAccatcgtgcgcgacttcttc	10	16	3	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:68882436A>C	uc010yqj.1	+	2	910	c.910A>C	c.(910-912)ACC>CCC	p.T304P	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	304	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						CTACGGCTTCACCATCGTGCG	0.587													0	0	0	0.010729	0	11	93										C	68882436	A	C	68882436	3	2	17	1	0	0	0	0	1	0	0	0	12552	159	6	5	916	5	PROKR1	2	68882436	Missense_Mutation	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08		68882436	174316937	14	4460										
FBXO41	150726	broad.mit.edu	37	chr2	73492583	73492583	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gccagttctggatggcctggCgccgcaggcctgagctgcga	16	13	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:73492583C>T	uc002sjb.1	-	5	1574	c.1574G>A	c.(1573-1575)CGC>CAC	p.R525H		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	464						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						GATGGCCTGGCGCCGCAGGCC	0.701													0	0	0	0.004672	0	3	29										T	73492583	C	T	73492583	3	4	17	1	0	0	0	0	1	0	0	0	5750	768	27	2	1272	2	FBXO41	2	73492583	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	4610147	73492583	169706790	15	4461										
WBP1	23559	broad.mit.edu	37	chr2	74687437	74687437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cttatactgtggccccaggcCgccccttgactgcttccagt	9	16	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:74687437C>T	uc002slj.1	+	4	592	c.439C>T	c.(439-441)CGC>TGC	p.R147C	WBP1_uc002slh.1_RNA|INO80B_uc002sli.1_RNA|WBP1_uc002slk.1_Missense_Mutation_p.R144C|WBP1_uc002sll.1_RNA	NM_012477	NP_036609	Q96G27	WBP1_HUMAN	WW domain binding protein 1	147							WW domain binding				0						GGCCCCAGGCCGCCCCTTGAC	0.602													0	0	0	0.01441	0	51	247										T	74687437	C	T	74687437	3	4	17	1	0	0	0	0	1	0	0	0	17254	652	23	2	453	2	WBP1	2	74687437	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	1194854	74687437	168511936	16	4462										
SLC4A10	57282	broad.mit.edu	37	chr2	162820755	162820755	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctcttcacaattattcagatGagttgccttggccttttgtg	8	9	3	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:162820755G>A	uc002ubx.3	+	22	3157	c.2973G>A	c.(2971-2973)ATG>ATA	p.M991I	SLC4A10_uc002uby.3_Missense_Mutation_p.M961I|SLC4A10_uc010zcs.1_Missense_Mutation_p.M972I	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	991	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TTATTCAGATGAGTTGCCTTG	0.393													0	0	0	0.009096	0	3	23										A	162820755	G	A	162820755	3	1	17	1	0	0	0	0	1	0	0	0	14651	1290	45	1	3144	1	SLC4A10	2	162820755	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	88133318	162820755	80378618	17	4463										
TTN	7273	broad.mit.edu	37	chr2	179408943	179408943	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aatacctattctttccacggGctcaatttcagcaattgatt	5	10	3	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:179408943G>T	uc010zfg.1	-	294	88533	c.88309C>A	c.(88309-88311)CCC>ACC	p.P29437T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P23132T|TTN_uc010zfi.1_Missense_Mutation_p.P23065T|TTN_uc010zfj.1_Missense_Mutation_p.P22940T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30364							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTCCACGGGCTCAATTTCA	0.388													1	0	0.00307968	0.00308	0.00331658	7	54										T	179408943	G	T	179408943	3	4	17	1	0	0	0	0	1	0	0	0	16732	1203	42	4	12038	4	TTN	2	179408943	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	16588188	179408943	63790430	18	4464										
TTN	7273	broad.mit.edu	37	chr2	179591911	179591911	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tcctcagtactgagattgttCatctgtatgacggccactga	9	10	3	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:179591911C>T	uc010zfg.1	-	66	16673	c.16449G>A	c.(16447-16449)ATG>ATA	p.M5483I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.M2144I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6410							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGATTGTTCATCTGTATGA	0.453													0	0	0	0.014758	0	5	78										T	179591911	C	T	179591911	3	4	17	1	0	0	0	0	1	0	0	0	16732	826	29	1	84524	1	TTN	2	179591911	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	182968	179591911	63607462	19	4465										
ZNF804A	91752	broad.mit.edu	37	chr2	185801399	185801399	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aaagacaatgtgagccatttGtacctgtccttaacaaacac	6	10	0	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:185801399G>T	uc002uph.2	+	4	1870	c.1276G>T	c.(1276-1278)GTA>TTA	p.V426L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	426						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGAGCCATTTGTACCTGTCCT	0.373													1	0	1.5739e-10	0.028581	1.82241e-10	16	85										T	185801399	G	T	185801399	3	4	17	1	0	0	0	0	1	0	0	0	18167	1377	48	4	1290	4	ZNF804A	2	185801399	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	6209488	185801399	57397974	20	4466										
ZNF142	7701	broad.mit.edu	37	chr2	219514052	219514052	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aagaacttctggcagttaggGcactggaggctggggtctgg	17	7	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:219514052G>A	uc002vin.2	-	6	1015	c.579C>T	c.(577-579)TGC>TGT	p.C193C	ZNF142_uc002vil.2_Silent_p.C154C|ZNF142_uc010fvt.2_Silent_p.C30C|ZNF142_uc002vim.2_Silent_p.C30C	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGCAGTTAGGGCACTGGAGGC	0.557											OREG0015202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.020292	0	13	37										A	219514052	G	A	219514052	2	1	17	1	0	0	0	0	0	0	0	1	17728	1195	42	2		2	ZNF142	2	219514052	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	33712653	219514052	23685321	21	4467										
KIF1A	547	broad.mit.edu	37	chr2	241710435	241710435	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gcccggggcaaacaagatgcGctcgtggaggctggacacgg	17	11	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr2:241710435G>A	uc002vzy.2	-	14	1413	c.1267C>T	c.(1267-1269)CGC>TGC	p.R423C	KIF1A_uc010fzk.2_Missense_Mutation_p.R432C|KIF1A_uc002vzz.1_Missense_Mutation_p.R432C	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	423					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AACAAGATGCGCTCGTGGAGG	0.647													0	0	0	0.025465	0	38	80										A	241710435	G	A	241710435	3	1	17	1	0	0	0	0	1	0	0	0	8283	1087	38	2	3941	2	KIF1A	2	241710435	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	22196383	241710435	1488938	22	4468										
CNOT10	25904	broad.mit.edu	37	chr3	32811403	32811403	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cttcaatgatccatcctaaaGaggtgccccctgaggccatc	8	14	1	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:32811403G>A	uc003cfc.1	+	18	2284	c.2029G>A	c.(2029-2031)GAG>AAG	p.E677K	CNOT10_uc003cfd.1_Missense_Mutation_p.E676K|CNOT10_uc003cfe.1_Missense_Mutation_p.E650K|CNOT10_uc010hfv.1_Intron|CNOT10_uc011axj.1_Missense_Mutation_p.E737K|CNOT10_uc010hfw.1_Missense_Mutation_p.E372K	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	677					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						CCATCCTAAAGAGGTGCCCCC	0.453													0	0	0	0.013537	0	10	91										A	32811403	G	A	32811403	3	1	17	1	0	0	0	0	1	0	0	0	3618	943	33	1	2099	1	CNOT10	3	32811403	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		32811403	165211027	23	4469										
KBTBD5	131377	broad.mit.edu	37	chr3	42732383	42732383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cgaggccttcccacaggagcGtagctcactcagcctggtca	11	15	3	0	rs144187563		TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:42732383G>A	uc003clv.1	+	5	1740	c.1640G>A	c.(1639-1641)CGT>CAT	p.R547H		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	547	Kelch 4.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CCACAGGAGCGTAGCTCACTC	0.617													0	0	0	0.008291	0	8	74										A	42732383	G	A	42732383	3	1	17	1	0	0	0	0	1	0	0	0	7996	1145	40	2	1658	2	KBTBD5	3	42732383	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	9920980	42732383	155290047	24	4470										
CCR5	1234	broad.mit.edu	37	chr3	46415257	46415257	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acagagactcttgggatgacGcactgctgcatcaaccccat	9	13	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:46415257G>A	uc003cpo.3	+	3	986	c.864G>A	c.(862-864)ACG>ACA	p.T288T	CCR5_uc010hjd.2_Silent_p.T288T	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	288	Helical; Name=7; (Potential).		T -> M (in INCCR5-72A).		cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	TTGGGATGACGCACTGCTGCA	0.473													0	0	0	0.021523	0	24	376										A	46415257	G	A	46415257	2	1	17	1	0	0	0	0	0	0	0	1	2944	1074	38	2		2	CCR5	3	46415257	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	3682874	46415257	151607173	25	4471										
RHOA	387	broad.mit.edu	37	chr3	49412958	49412958	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggtccttgctgaagactatgAgcaagcatgtctttccacag	10	10	1	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:49412958A>G	uc003cwu.2	-	2	341	c.65T>C	c.(64-66)CTC>CCC	p.L22P	RHOA_uc010hku.2_Intron	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	22					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GAAGACTATGAGCAAGCATGT	0.473													0	0	0	0.030466	0	42	82										G	49412958	A	G	49412958	3	3	17	1	0	0	0	0	1	0	0	0	13331	304	11	5	532	5	RHOA	3	49412958	Missense_Mutation	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	2997701	49412958	148609472	26	4472										
VPRBP	9730	broad.mit.edu	37	chr3	51457623	51457623	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctagcggaccctgggggggcCgtggctgaggatgagcagta	19	9	0	2	rs114108730	by1000genomes	TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:51457623C>T	uc003dbe.1	-	14	2969	c.2801G>A	c.(2800-2802)CGG>CAG	p.R934Q	VPRBP_uc003dbf.1_Missense_Mutation_p.R210Q	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	934					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CTGGGGGGGCCGTGGCTGAGG	0.597													0	0	0	0.024245	0	15	47										T	51457623	C	T	51457623	3	4	17	1	0	0	0	0	1	0	0	0	17182	652	23	2	1766	2	VPRBP	3	51457623	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	2044665	51457623	146564807	27	4473										
SENP7	57337	broad.mit.edu	37	chr3	101212807	101212807	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggttttgcatttaacatcttTcttatctgaaaataggatga	7	5	3	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:101212807T>C	uc003dut.2	-	3	207	c.96A>G	c.(94-96)AGA>AGG	p.R32R	SENP7_uc003duu.2_Silent_p.R32R|SENP7_uc003duv.2_5'UTR|SENP7_uc003duw.2_Silent_p.R32R|SENP7_uc003dux.2_5'UTR	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	32					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						TTAACATCTTTCTTATCTGAA	0.358													0	0	0	0.0333	0	14	28										C	101212807	T	C	101212807	2	2	17	1	0	0	0	0	0	0	0	1	14051	1780	62	5		5	SENP7	3	101212807	Silent	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	49755184	101212807	96809623	28	4474										
STXBP5L	9515	broad.mit.edu	37	chr3	121137298	121137298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggtgatgggagagctgacccGtgcacggattgcacttgatg	16	8	0	4			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:121137298G>A	uc003eec.3	+	27	3553	c.3413G>A	c.(3412-3414)CGT>CAT	p.R1138H	STXBP5L_uc011bji.1_Missense_Mutation_p.R1114H	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	1138	v-SNARE coiled-coil homology.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GAGCTGACCCGTGCACGGATT	0.532													0	0	0	0.013726	0	32	32										A	121137298	G	A	121137298	3	1	17	1	0	0	0	0	1	0	0	0	15356	1145	40	2	3515	2	STXBP5L	3	121137298	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	19924491	121137298	76885132	29	4475										
KALRN	8997	broad.mit.edu	37	chr3	124132333	124132333	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acaggtgacagcagagctagAcgcctggaatgaagacttgc	13	9	0	5			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr3:124132333A>G	uc003ehg.2	+	14	2484	c.2357A>G	c.(2356-2358)GAC>GGC	p.D786G	KALRN_uc010hrv.1_Missense_Mutation_p.D786G|KALRN_uc003ehf.1_Missense_Mutation_p.D786G|KALRN_uc011bjy.1_Missense_Mutation_p.D786G|KALRN_uc003ehh.1_Missense_Mutation_p.D132G	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	786					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GCAGAGCTAGACGCCTGGAAT	0.527													0	0	0	0.014758	0	5	40										G	124132333	A	G	124132333	3	3	17	1	0	0	0	0	1	0	0	0	7975	275	10	5	2411	5	KALRN	3	124132333	Missense_Mutation	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	2995035	124132333	73890097	30	4476										
MXD4	10608	broad.mit.edu	37	chr4	2254190	2254190	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gcgtggtgtggcgggtgctgTcggggcccaggggcaccagt	21	10	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr4:2254190T>C	uc003geu.1	-	4	286	c.254A>G	c.(253-255)GAC>GGC	p.D85G		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	85	Helix-loop-helix motif.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						GCGGGTGCTGTCGGGGCCCAG	0.637													0	0	0	0.013537	0	13	50										C	2254190	T	C	2254190	3	2	17	1	0	0	0	0	1	0	0	0	10001	1667	58	5	387	5	MXD4	4	2254190	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08		2254190	188900086	31	4477										
PPP2R2C	5522	broad.mit.edu	37	chr4	6473933	6473933	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aggaagctgtggttaattttCcgcgtgtccgtgtcctcgcc	12	11	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr4:6473933C>T	uc003gjc.2	-	1	394	c.24G>A	c.(22-24)CGG>CGA	p.R8R	PPP2R2C_uc011bwd.1_Intron|PPP2R2C_uc011bwe.1_Intron	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	8					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						GGTTAATTTTCCGCGTGTCCG	0.667													0	0	0	0.015359	0	31	237										T	6473933	C	T	6473933	2	4	17	1	0	0	0	0	0	0	0	1	12386	842	30	1		1	PPP2R2C	4	6473933	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	4219743	6473933	184680343	32	4478										
SORCS2	57537	broad.mit.edu	37	chr4	7725484	7725484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acggcttcaaggccatgtacGtgaaccttacactgaccggg	11	12	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr4:7725484G>A	uc003gkb.3	+	19	2485	c.2485G>A	c.(2485-2487)GTG>ATG	p.V829M	SORCS2_uc011bwi.1_Missense_Mutation_p.V657M	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	829	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GGCCATGTACGTGAACCTTAC	0.607													0	0	0	0.010504	0	19	185										A	7725484	G	A	7725484	3	1	17	1	0	0	0	0	1	0	0	0	14931	1145	40	2	2559	2	SORCS2	4	7725484	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	1251551	7725484	183428792	33	4479										
ANKRD50	57182	broad.mit.edu	37	chr4	125591960	125591960	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cgtaccacctcaacatttccTtgtgctgaagctatactgag	7	12	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr4:125591960T>C	uc003ifg.3	-	3	2738	c.2472A>G	c.(2470-2472)CAA>CAG	p.Q824Q	ANKRD50_uc011cgo.1_Silent_p.Q645Q|ANKRD50_uc010inw.2_Silent_p.Q824Q	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	824	ANK 11.									central_nervous_system(1)	1						CAACATTTCCTTGTGCTGAAG	0.438													0	0	0	0.00308	0	8	86										C	125591960	T	C	125591960	2	2	17	1	0	0	0	0	0	0	0	1	677	1606	56	5		5	ANKRD50	4	125591960	Silent	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	117866476	125591960	65562316	34	4480										
PLEKHG4B	153478	broad.mit.edu	37	chr5	162962	162962	+	Frame_Shift_Del	DEL	G	G	-													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gccttccccggggcaggtgtGgcagtgctgaagcctcatgc							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr5:162962delG	uc003jak.2	+	11	1757	c.1707delG	c.(1705-1707)GTGfs	p.V569fs		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	569					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GGGCAGGTGTGGCAGTGCTGA	0.647																		2	4	---	---								-	162962	G	-	162962	7	5	17	1	0	1	0	1	0	0	0	0	12072	1335	47	0	1749	0	PLEKHG4B	5	162962	Frame_Shift_Del	DEL	G	TCGA-BT-A2LD-01A-12D-A20D-08		162962	180752298	35	4481										
UGT3A1	133688	broad.mit.edu	37	chr5	35957445	35957445	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgaggacttcctgggactgaTgggtgttcaacatggagcca	14	8	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr5:35957445T>C	uc003jjv.1	-	5	1077	c.920A>G	c.(919-921)CAT>CGT	p.H307R	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.H307R|UGT3A1_uc011cor.1_Missense_Mutation_p.H273R	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	307	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTGGGACTGATGGGTGTTCAA	0.488													0	0	0	0.02938	0	5	55										C	35957445	T	C	35957445	3	2	17	1	0	0	0	0	1	0	0	0	16960	1464	51	5	663	5	UGT3A1	5	35957445	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	35794483	35957445	144957815	36	4482										
NSA2	10412	broad.mit.edu	37	chr5	74069827	74069827	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gttattaccaaaggtactgtCattgaagtaaatgtgagcga	10	5	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr5:74069827C>T	uc003kdk.1	+	5	740	c.657C>T	c.(655-657)GTC>GTT	p.V219V		NM_014886	NP_055701	O95478	NSA2_HUMAN	NSA2 ribosome biogenesis homolog	219					rRNA processing	nucleolus|ribonucleoprotein complex				ovary(1)	1						AAGGTACTGTCATTGAAGTAA	0.423													0	0	0	0.00308	0	7	79										T	74069827	C	T	74069827	2	4	17	1	0	0	0	0	0	0	0	1	10668	813	29	1		1	NSA2	5	74069827	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	38112382	74069827	106845433	37	4483										
PPIP5K2	23262	broad.mit.edu	37	chr5	102502895	102502895	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	atttgtagcttactccatctGgaagcatttctcttatcaaa	5	9	3	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr5:102502895G>A	uc003kod.3	+	18	2452	c.1933G>A	c.(1933-1935)GGA>AGA	p.G645R	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.G645R|PPIP5K2_uc003kof.2_5'Flank	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	645					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TACTCCATCTGGAAGCATTTC	0.294													0	0	0	0.02938	0	6	38										A	102502895	G	A	102502895	3	1	17	1	0	0	0	0	1	0	0	0	12333	1349	47	2	1999	2	PPIP5K2	5	102502895	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	28433068	102502895	78412365	38	4484										
PHF15	23338	broad.mit.edu	37	chr5	133914401	133914401	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccctcgctgcgacctggtgaCcctgctaggaaggcccgagg	14	15	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr5:133914401C>T	uc003kzo.1	+	11	1946	c.1767C>T	c.(1765-1767)GAC>GAT	p.D589D	PHF15_uc011cxt.1_Silent_p.D633D|PHF15_uc003kzk.2_Silent_p.D649D|PHF15_uc003kzl.2_3'UTR|PHF15_uc003kzm.2_Silent_p.D590D|PHF15_uc003kzn.2_3'UTR	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	589					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACCTGGTGACCCTGCTAGGA	0.662													0	0	0	0.02938	0	6	32										T	133914401	C	T	133914401	2	4	17	1	0	0	0	0	0	0	0	1	11826	506	18	2		2	PHF15	5	133914401	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	31411506	133914401	47000859	39	4485										
FGFR4	2264	broad.mit.edu	37	chr5	176520735	176520735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctttggcatggaccctgcccGgcctgaccaagccagcactg	11	16	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr5:176520735G>A	uc003mfl.2	+	11	1645	c.1478G>A	c.(1477-1479)CGG>CAG	p.R493Q	FGFR4_uc003mfm.2_Missense_Mutation_p.R493Q|FGFR4_uc011dfu.1_Missense_Mutation_p.R425Q|FGFR4_uc003mfo.2_Missense_Mutation_p.R453Q	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	493	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GACCCTGCCCGGCCTGACCAA	0.453										TSP Lung(9;0.080)			0	0	0	0.014758	0	5	42										A	176520735	G	A	176520735	3	1	17	1	0	0	0	0	1	0	0	0	5868	1116	39	2	1586	2	FGFR4	5	176520735	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	42606334	176520735	4394525	40	4486										
E2F3	1871	broad.mit.edu	37	chr6	20402595	20402597	+	In_Frame_Del	DEL	CGC	CGC	-													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctgctagccagccccggcttCgccgccgccgccgccgctgc							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:20402595_20402597delCGC	uc003nda.2	+	1	459_461	c.132_134delCGC	c.(130-135)TTCGCC>TTC	p.A53del	E2F3_uc003ncz.2_In_Frame_Del_p.A53del	NM_001949	NP_001940	O00716	E2F3_HUMAN	E2F transcription factor 3	53	Poly-Ala.				G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			GCCCCGGCTTcgccgccgccgcc	0.591																		19	692	---	---								-	20402597	CGC	-	20402595	7	5	17	1	0	1	0	1	0	0	0	0	4868	883	31	0	134	0	E2F3	6	20402595	In_Frame_Del	DEL	CGC	TCGA-BT-A2LD-01A-12D-A20D-08		20402595	150712472	41	4487										
BTN2A2	10385	broad.mit.edu	37	chr6	26384093	26384093	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cttctccctgccagcctcccTcctcctcctcctgctcctcc	3	25	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:26384093T>C	uc003nhq.2	+	2	130	c.44T>C	c.(43-45)CTC>CCC	p.L15P	BTN2A2_uc011dkf.1_Missense_Mutation_p.L15P|BTN2A2_uc011dkg.1_Missense_Mutation_p.L15P|BTN2A2_uc003nhr.2_Missense_Mutation_p.L15P|BTN2A2_uc011dkh.1_Missense_Mutation_p.L15P|BTN2A2_uc003nhs.2_Missense_Mutation_p.L15P|BTN2A2_uc003nht.2_Missense_Mutation_p.L15P	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	15					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						CCAGCCTCcctcctcctcctc	0.483													0	0	0	0.021553	0	3	101										C	26384093	T	C	26384093	3	2	17	1	0	0	0	0	1	0	0	0	1561	1551	54	5	46	5	BTN2A2	6	26384093	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	5981498	26384093	144730974	42	4488										
PBX2	5089	broad.mit.edu	37	chr6	32154671	32154671	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctgagagattgaaagagccGccagagccttgtgggggcag	16	9	0	5			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:32154671G>A	uc003oav.1	-	7	1303	c.1032C>T	c.(1030-1032)GGC>GGT	p.G344G	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	344							transcription factor binding			ovary(1)	1						TGAAAGAGCCGCCAGAGCCTT	0.527													0	0	0	0.004672	0	3	49										A	32154671	G	A	32154671	2	1	17	1	0	0	0	0	0	0	0	1	11493	1074	38	2		2	PBX2	6	32154671	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	5770578	32154671	138960396	43	4489										
PNRC1	10957	broad.mit.edu	37	chr6	89793784	89793784	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	attatgctggggcaaagtttAgtgatccaccttctcctagt	9	9	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:89793784A>T	uc003pmv.2	+	2	1038	c.853A>T	c.(853-855)AGT>TGT	p.S285C	PNRC1_uc003pmx.2_Missense_Mutation_p.S100C	NM_006813	NP_006804	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	285	SH3-binding.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		GGCAAAGTTTAGTGATCCACC	0.408										Multiple Myeloma(7;0.094)			0	0	0	0.004672	0	3	57										T	89793784	A	T	89793784	3	4	17	1	0	0	0	0	1	0	0	0	12174	420	15	5	859	5	PNRC1	6	89793784	Missense_Mutation	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	57639113	89793784	81321283	44	4490										
REV3L	5980	broad.mit.edu	37	chr6	111688580	111688580	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctatcatctccatttaatgcTttggaatctggggatattgg	9	7	3	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:111688580T>C	uc003puy.3	-	14	6734	c.6411A>G	c.(6409-6411)AAA>AAG	p.K2137K	REV3L_uc003pux.3_Silent_p.K2059K|REV3L_uc003puz.3_Silent_p.K2059K|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2137					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CATTTAATGCTTTGGAATCTG	0.378								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.028581	0	14	109										C	111688580	T	C	111688580	2	2	17	1	0	0	0	0	0	0	0	1	13240	1606	56	5		5	REV3L	6	111688580	Silent	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	21894796	111688580	59426487	45	4491										
CTAGE9	643854	broad.mit.edu	37	chr6	132031779	132031779	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ttcacaggttgcctccaaacTtcgtgcttcttctgctgccg	8	14	3	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:132031779T>C	uc011ece.1	-	1	379	c.379A>G	c.(379-381)AGT>GGT	p.S127G	ENPP3_uc003qcu.3_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_001145659	NP_001139131	A4FU28	CTGE9_HUMAN	CTAGE family, member 4-like	127	Potential.					integral to membrane					0						GCCTCCAAACTTCGTGCTTCT	0.403													0	0	0	0.014323	0	18	107										C	132031779	T	C	132031779	3	2	17	1	0	0	0	0	1	0	0	0	3996	1609	56	5	1958	5	CTAGE9	6	132031779	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	20343199	132031779	39083288	46	4492										
FNDC1	84624	broad.mit.edu	37	chr6	159654483	159654483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccgccacgcgtcccctgctcGtccgcccgcagcacggtcac	10	22	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr6:159654483G>A	uc010kjv.2	+	11	3139	c.2939G>A	c.(2938-2940)CGT>CAT	p.R980H	FNDC1_uc010kjw.1_Missense_Mutation_p.R865H	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	980						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TCCCCTGCTCGTCCGCCCGCA	0.662													0	0	0	0.006214	0	5	15										A	159654483	G	A	159654483	3	1	17	1	0	0	0	0	1	0	0	0	5968	1145	40	2	2981	2	FNDC1	6	159654483	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	27622704	159654483	11460584	47	4493										
MEOX2	4223	broad.mit.edu	37	chr7	15652118	15652118	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	caccaattcccgacagctctGatgggagaagtgttcccttt	9	12	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:15652118G>C	uc003stc.2	-	3	1090	c.809C>G	c.(808-810)TCA>TGA	p.S270*	MEOX2_uc011jxw.1_Nonsense_Mutation_p.S270*	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	270					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CGACAGCTCTGATGGGAGAAG	0.537													0	0	0	0.006214	0	10	176										C	15652118	G	C	15652118	4	2	17	1	0	0	0	0	0	1	0	0	9474	1294	45	1	109	1	MEOX2	7	15652118	Nonsense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		15652118	143486545	48	4494										
CRHR2	1395	broad.mit.edu	37	chr7	30704745	30704745	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	caggaaccacatgacatttcGcaggataaaggtggtgatga	12	7	0	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:30704745G>A	uc003tbn.2	-	5	728	c.484C>T	c.(484-486)CGA>TGA	p.R162*	CRHR2_uc010kvw.1_Nonsense_Mutation_p.R162*|CRHR2_uc010kvx.1_Nonsense_Mutation_p.R161*|CRHR2_uc010kvy.1_5'UTR|CRHR2_uc003tbo.2_Nonsense_Mutation_p.R148*|CRHR2_uc003tbp.2_Nonsense_Mutation_p.R189*	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	162	Helical; Name=2; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						ATGACATTTCGCAGGATAAAG	0.572													0	0	0	0.02938	0	6	81										A	30704745	G	A	30704745	4	1	17	1	0	0	0	0	0	1	0	0	3872	1095	38	2	783	2	CRHR2	7	30704745	Nonsense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	15052627	30704745	128433918	49	4495										
SBDS	51119	broad.mit.edu	37	chr7	66459244	66459244	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tctgttccaaacgcactgatGagatcttcctttttggcaac	7	11	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:66459244G>A	uc003tvm.1	-	2	397	c.213C>T	c.(211-213)CTC>CTT	p.L71L	TYW1_uc003tvn.2_5'Flank|TYW1_uc010lai.2_5'Flank	NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	71					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						ACGCACTGATGAGATCTTCCT	0.428			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				0	0	0	0.013537	0	9	119										A	66459244	G	A	66459244	2	1	17	1	0	0	0	0	0	0	0	1	13857	1277	45	1		1	SBDS	7	66459244	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	35754499	66459244	92679419	50	4496										
PPP1R9A	55607	broad.mit.edu	37	chr7	94917928	94917928	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tggagtgtgcagcaggtttcTcactggttaatgagcctaaa	12	7	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:94917928T>C	uc003unp.2	+	15	3264	c.2982T>C	c.(2980-2982)TCT>TCC	p.S994S	PPP1R9A_uc010lfj.2_Silent_p.S1270S|PPP1R9A_uc011kif.1_Silent_p.S1192S|PPP1R9A_uc003unq.2_Intron|PPP1R9A_uc011kig.1_Silent_p.S986S|PPP1R9A_uc003unr.2_Silent_p.S283S	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	994	Interacts with TGN38 (By similarity).|SAM.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGCAGGTTTCTCACTGGTTAA	0.448										HNSCC(28;0.073)			0	0	0	0.013537	0	12	100										C	94917928	T	C	94917928	2	2	17	1	0	0	0	0	0	0	0	1	12378	1538	54	5		5	PPP1R9A	7	94917928	Silent	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	28458684	94917928	64220735	51	4497										
MUC17	140453	broad.mit.edu	37	chr7	100679464	100679464	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	atgctggtggtcagttctgaGgctaacaccctttcaacaac	9	11	3	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:100679464G>C	uc003uxp.1	+	3	4820	c.4767G>C	c.(4765-4767)GAG>GAC	p.E1589D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1589	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|24.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGTTCTGAGGCTAACACCC	0.488													0	0	0	0.021523	0	26	383										C	100679464	G	C	100679464	3	2	17	1	0	0	0	0	1	0	0	0	9974	991	35	4	4777	4	MUC17	7	100679464	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	5761536	100679464	58459199	52	4498										
HYAL4	23553	broad.mit.edu	37	chr7	123516944	123516944	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cataaggaagatgtggaacgCgcccagttaccttcacttga	10	10	1	2	rs150077532	byFrequency	TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:123516944C>T	uc003vlc.2	+	5	1819	c.1181C>T	c.(1180-1182)GCG>GTG	p.A394V	HYAL4_uc011knz.1_3'UTR	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	394	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						ATGTGGAACGCGCCCAGTTAC	0.507													0	0	0	0.012319	0	21	72										T	123516944	C	T	123516944	3	4	17	1	0	0	0	0	1	0	0	0	7466	768	27	2	1191	2	HYAL4	7	123516944	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	22837480	123516944	35621719	53	4499										
CCDC136	64753	broad.mit.edu	37	chr7	128452358	128452358	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aggaacctgctgagcctgaaGacatggaggtaatggttgcc	14	8	0	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:128452358G>C	uc003vnv.1	+	13	2900	c.2533G>C	c.(2533-2535)GAC>CAC	p.D845H	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Missense_Mutation_p.D661H|CCDC136_uc010llq.1_Missense_Mutation_p.D214H|CCDC136_uc003vny.1_Missense_Mutation_p.D455H	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	845						integral to membrane	protein binding			ovary(2)	2						TGAGCCTGAAGACATGGAGGT	0.522													0	0	0	0.004672	0	3	15										C	128452358	G	C	128452358	3	2	17	1	0	0	0	0	1	0	0	0	2770	942	33	1	2583	1	CCDC136	7	128452358	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	4935414	128452358	30686305	54	4500										
OR2A12	346525	broad.mit.edu	37	chr7	143792375	143792375	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctagactgcacacacccatgTatgtcttcctgtcacacctg	6	15	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:143792375T>C	uc011kty.1	+	1	175	c.175T>C	c.(175-177)TAT>CAT	p.Y59H		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					CACACCCATGTATGTCTTCCT	0.463													0	0	0	0.021553	0	5	109										C	143792375	T	C	143792375	3	2	17	1	0	0	0	0	1	0	0	0	10975	1638	57	5	177	5	OR2A12	7	143792375	Missense_Mutation	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08	15340017	143792375	15346288	55	4501										
CNTNAP2	26047	broad.mit.edu	37	chr7	147600794	147600794	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccaagtactactgtaactgcGacgcggactacaagcaatgg	10	11	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:147600794G>A	uc003weu.1	+	14	2752	c.2236G>A	c.(2236-2238)GAC>AAC	p.D746N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	746	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTGTAACTGCGACGCGGACTA	0.547										HNSCC(39;0.1)			0	0	0	0.004482	0	8	30										A	147600794	G	A	147600794	3	1	17	1	0	0	0	0	1	0	0	0	3647	1058	37	1	2290	1	CNTNAP2	7	147600794	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	3808419	147600794	11537869	56	4502										
NOS3	4846	broad.mit.edu	37	chr7	150696071	150696071	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctggaccccaggaaacggtcGcttcgacgtgctgcccctgc	12	16	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr7:150696071G>A	uc003wif.2	+	8	1150	c.854G>A	c.(853-855)CGC>CAC	p.R285H	NOS3_uc011kuy.1_Missense_Mutation_p.R79H|NOS3_uc011kuz.1_Missense_Mutation_p.R285H|NOS3_uc011kva.1_Missense_Mutation_p.R285H|NOS3_uc011kvb.1_Missense_Mutation_p.R285H	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	285	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GGAAACGGTCGCTTCGACGTG	0.672													0	0	0	0.017118	0	36	133										A	150696071	G	A	150696071	3	1	17	1	0	0	0	0	1	0	0	0	10544	1087	38	2	880	2	NOS3	7	150696071	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	3095277	150696071	8442592	57	4503										
DLC1	10395	broad.mit.edu	37	chr8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccgactggctgctgctgctgCtggtctgcgtggagttggaa	16	10	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr8:12957624C>G	uc003wwm.2	-	9	2666	c.2222G>C	c.(2221-2223)AGC>ACC	p.S741T	DLC1_uc003wwk.1_Missense_Mutation_p.S304T|DLC1_uc003wwl.1_Missense_Mutation_p.S338T|DLC1_uc011kxx.1_Missense_Mutation_p.S230T	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GCTGCTGCTGCTGGTCTGCGT	0.627													0	0	0	0.02938	0	6	82										G	12957624	C	G	12957624	3	3	17	1	0	0	0	0	1	0	0	0	4550	797	28	4	2404	4	DLC1	8	12957624	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		12957624	133406398	58	4504										
VDAC3	7419	broad.mit.edu	37	chr8	42260958	42260958	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	attgctgctaagtacatgctGgattgtagaacttctctctc	8	9	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr8:42260958G>A	uc011lct.1	+	8	824	c.681G>A	c.(679-681)CTG>CTA	p.L227L	VDAC3_uc003xpc.2_Silent_p.L228L	NM_005662	NP_005653	Q9Y277	VDAC3_HUMAN	voltage-dependent anion channel 3 isoform b	227	Beta stranded; (By similarity).				adenine transport	mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			upper_aerodigestive_tract(1)	1	all_cancers(6;3.86e-23)|all_lung(13;6.47e-12)|Lung NSC(13;1.08e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00266)|Lung(22;0.00849)|LUSC - Lung squamous cell carcinoma(45;0.024)		Dihydroxyaluminium(DB01375)	AGTACATGCTGGATTGTAGAA	0.413													0	0	0	0.009096	0	4	113										A	42260958	G	A	42260958	2	1	17	1	0	0	0	0	0	0	0	1	17145	1335	47	2		2	VDAC3	8	42260958	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	29303334	42260958	104103064	59	4505										
ZNF704	619279	broad.mit.edu	37	chr8	81582753	81582753	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cttaccccagatggatggttCggatgtgtttctggatacct	11	9	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr8:81582753C>T	uc003yby.1	-	5	876	c.644G>A	c.(643-645)CGA>CAA	p.R215Q		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	215	C2H2-type.					intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			ATGGATGGTTCGGATGTGTTT	0.527													0	0	0	0.016723	0	10	114										T	81582753	C	T	81582753	3	4	17	1	0	0	0	0	1	0	0	0	18104	884	31	1	614	1	ZNF704	8	81582753	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	39321795	81582753	64781269	60	4506										
CTHRC1	115908	broad.mit.edu	37	chr8	104394752	104394752	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tatctgggttggtacttgttCagattacccaaaaggagatg	11	6	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr8:104394752C>T	uc003ylk.2	+	4	755	c.656C>T	c.(655-657)TCA>TTA	p.S219L		NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	219						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			GGTACTTGTTCAGATTACCCA	0.373													0	0	0	0.024245	0	11	118										T	104394752	C	T	104394752	3	4	17	1	0	0	0	0	1	0	0	0	4010	838	29	1	670	1	CTHRC1	8	104394752	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	22811999	104394752	41969270	61	4507										
CTHRC1	115908	broad.mit.edu	37	chr8	104394804	104394804	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tggaattcagtttctcgcatCattattgaagaactaccaaa	6	8	3	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr8:104394804C>T	uc003ylk.2	+	4	807	c.708C>T	c.(706-708)ATC>ATT	p.I236I		NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	236						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			TTTCTCGCATCATTATTGAAG	0.343													0	0	0	0.008291	0	9	92										T	104394804	C	T	104394804	2	4	17	1	0	0	0	0	0	0	0	1	4010	816	29	1		1	CTHRC1	8	104394804	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	52	104394804	41969218	62	4508										
BAAT	570	broad.mit.edu	37	chr9	104124824	104124824	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acctctcctccccagtgtaaCctcaaatcgtgggtcgttga	8	14	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr9:104124824C>T	uc010mtd.2	-	4	1252	c.1143G>A	c.(1141-1143)AGG>AGA	p.R381R	BAAT_uc004bbd.3_Silent_p.R381R	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	381					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	CCCAGTGTAACCTCAAATCGT	0.537													0	0	0	0.021553	0	6	47										T	104124824	C	T	104124824	2	4	17	1	0	0	0	0	0	0	0	1	1280	506	18	2		2	BAAT	9	104124824	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		104124824	37088607	63	4509										
AMBP	259	broad.mit.edu	37	chr9	116840418	116840418	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acttggatgttgtcgggcggCgttggcacagggccagcgct	17	10	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr9:116840418C>T	uc004bie.3	-	1	335	c.72G>A	c.(70-72)ACG>ACA	p.T24T	AMBP_uc011lxk.1_5'Flank|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	24					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	TGTCGGGCGGCGTTGGCACAG	0.617													0	0	0	0.006214	0	9	88										T	116840418	C	T	116840418	2	4	17	1	0	0	0	0	0	0	0	1	564	755	27	2		2	AMBP	9	116840418	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	12715594	116840418	24373013	64	4510										
ADARB2	105	broad.mit.edu	37	chr10	1230959	1230959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gggcgacttccccggctggcGcgcctcggcgtcactcacgc	14	18	2	0	rs141253548	byFrequency	TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr10:1230959G>A	uc009xhq.2	-	9	2259	c.1885C>T	c.(1885-1887)CGC>TGC	p.R629C	ADARB2_uc009xhp.2_Missense_Mutation_p.R13C|ADARB2_uc001igl.3_5'UTR|ADARB2_uc001igm.3_Missense_Mutation_p.R138C	NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	629	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CCCGGCTGGCGCGCCTCGGCG	0.672													0	0	0	0.008291	0	10	80										A	1230959	G	A	1230959	3	1	17	1	0	0	0	0	1	0	0	0	283	1087	38	2	342	2	ADARB2	10	1230959	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		1230959	134303788	65	4511										
C10orf71	118461	broad.mit.edu	37	chr10	50534970	50534971	+	Frame_Shift_Del	DEL	AC	AC	-													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cccctcccccaaaacaagcaAcacacacacacacacacaca					rs72337199		TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr10:50534970_50534971delAC	uc010qgp.1	+	4	2408_2409	c.2069_2070delAC	c.(2068-2070)AACfs	p.N690fs		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	690											0						AAAACAAGCAacacacacacac	0.406																		2	4	---	---								-	50534971	AC	-	50534970	7	5	17	1	0	1	0	1	0	0	0	0	1614	58	2	0		0	C10orf71	10	50534970	Frame_Shift_Del	DEL	AC	TCGA-BT-A2LD-01A-12D-A20D-08	49304011	50534970	84999777	66	4512										
DOCK1	1793	broad.mit.edu	37	chr10	128798484	128798484	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	agaaaatcagttttgtctgtCagattgttcgcgtgggtcgc	12	7	3	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr10:128798484C>G	uc001ljt.2	+	10	962	c.898C>G	c.(898-900)CAG>GAG	p.Q300E	DOCK1_uc010qun.1_Missense_Mutation_p.Q300E	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	300					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TTTTGTCTGTCAGATTGTTCG	0.448													0	0	0	0.014758	0	4	39										G	128798484	C	G	128798484	3	3	17	1	0	0	0	0	1	0	0	0	4684	827	29	1	936	1	DOCK1	10	128798484	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	78263514	128798484	6736263	67	4513										
SAA2	6289	broad.mit.edu	37	chr11	18267001	18267001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gccccatttattggcagcctGatcggccagcgagtcctccg	11	15	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr11:18267001G>C	uc001mnz.3	-	4	329	c.292C>G	c.(292-294)CAG>GAG	p.Q98E	SAA2_uc009yhj.2_Intron	NM_030754	NP_110381	P02735	SAA_HUMAN	serum amyloid A2 isoform a	98				ADQAAN -> SEATVK (in Ref. 11; AA sequence).	acute-phase response|elevation of cytosolic calcium ion concentration|innate immune response|lymphocyte chemotaxis|macrophage chemotaxis|negative regulation of inflammatory response|neutrophil chemotaxis|platelet activation|positive regulation of cell adhesion|positive regulation of interleukin-1 secretion	high-density lipoprotein particle	G-protein-coupled receptor binding				0					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	TTGGCAGCCTGATCGGCCAGC	0.552													0	0	0	0.006214	0	9	111										C	18267001	G	C	18267001	3	2	17	1	0	0	0	0	1	0	0	0	13799	1299	45	1	106	1	SAA2	11	18267001	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		18267001	116739515	68	4514										
FAT3	120114	broad.mit.edu	37	chr11	92495148	92495148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	accagatcaagctgccagaaCgtgaccgaaagaagagagga	12	9	1	5			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr11:92495148C>T	uc001pdj.3	+	4	3813	c.3796C>T	c.(3796-3798)CGT>TGT	p.R1266C		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1266	Cadherin 12.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGCCAGAACGTGACCGAAA	0.473										TCGA Ovarian(4;0.039)			0	0	0	0.016723	0	12	117										T	92495148	C	T	92495148	3	4	17	1	0	0	0	0	1	0	0	0	5691	536	19	2	3810	2	FAT3	11	92495148	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	74228147	92495148	42511368	69	4515										
FAT3	120114	broad.mit.edu	37	chr11	92532073	92532073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgatggaaagttctacagtaCctccatggtcaccatcatgg	9	10	3	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr11:92532073C>T	uc001pdj.3	+	9	5911	c.5894C>T	c.(5893-5895)ACC>ATC	p.T1965I		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1965	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTCTACAGTACCTCCATGGTC	0.418										TCGA Ovarian(4;0.039)			0	0	0	0.013726	0	35	56										T	92532073	C	T	92532073	3	4	17	1	0	0	0	0	1	0	0	0	5691	507	18	2	5928	2	FAT3	11	92532073	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	36925	92532073	42474443	70	4516										
CNTN5	53942	broad.mit.edu	37	chr11	100211904	100211904	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggctgggaacccgtcataccAttagccaacgaatctgaagt	10	11	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr11:100211904A>G	uc001pga.2	+	23	3336	c.2997A>G	c.(2995-2997)CCA>CCG	p.P999P	CNTN5_uc001pgb.2_Silent_p.P925P|CNTN5_uc010ruk.1_Silent_p.P270P	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	999	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCGTCATACCATTAGCCAACG	0.433													0	0	0	0.024334	0	25	94										G	100211904	A	G	100211904	2	3	17	1	0	0	0	0	0	0	0	1	3644	204	8	5		5	CNTN5	11	100211904	Silent	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	7679831	100211904	34794612	71	4517										
PVRL1	5818	broad.mit.edu	37	chr11	119547811	119547811	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggtcagccctgcagcacttaCgtggtccagtggtactcagt	12	12	2	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr11:119547811C>T	uc001pwv.2	-	4	1023	c.851_splice	c.e4+1	p.T284_splice	PVRL1_uc001pwu.1_Splice_Site_p.T284_splice|PVRL1_uc001pww.2_Splice_Site_p.T284_splice	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1						adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GCAGCACTTACGTGGTCCAGT	0.577													0	0	0	0.020292	0	13	63										T	119547811	C	T	119547811	5	4	17	1	0	0	0	0	0	0	1	0	12839	550	19	2	1159	2	PVRL1	11	119547811	Splice_Site	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	19335907	119547811	15458705	72	4518										
SLC2A14	144195	broad.mit.edu	37	chr12	7970478	7970478	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aagttggaggtccagttggaGcagccggccactgccatcgc	14	12	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr12:7970478G>A	uc001qtk.2	-	15	2086	c.1293C>T	c.(1291-1293)TGC>TGT	p.C431C	SLC2A14_uc001qtl.2_Silent_p.C408C|SLC2A14_uc001qtm.2_Silent_p.C408C|SLC2A14_uc010sgg.1_Silent_p.C322C|SLC2A14_uc001qtn.2_Silent_p.C431C|SLC2A14_uc001qto.2_Silent_p.C66C|SLC2A14_uc010sgh.1_Silent_p.C446C	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	431	Helical; Name=11; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		TCCAGTTGGAGCAGCCGGCCA	0.483													0	0	0	0.0333	0	14	146										A	7970478	G	A	7970478	2	1	17	1	0	0	0	0	0	0	0	1	14543	963	34	2		2	SLC2A14	12	7970478	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		7970478	125881417	73	4519										
ADCY6	112	broad.mit.edu	37	chr12	49176704	49176704	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aggctgagggcgggcgggtgCggcgtggaaagccagcagca	21	9	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr12:49176704C>T	uc001rsh.3	-	1	1174	c.514G>A	c.(514-516)GCA>ACA	p.A172T	ADCY6_uc001rsj.3_Missense_Mutation_p.A172T|ADCY6_uc001rsi.3_Missense_Mutation_p.A172T	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	172					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CGGGCGGGTGCGGCGTGGAAA	0.647													0	0	0	0.00308	0	7	100										T	49176704	C	T	49176704	3	4	17	1	0	0	0	0	1	0	0	0	298	768	27	2	3076	2	ADCY6	12	49176704	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	41206226	49176704	84675191	74	4520										
DIP2B	57609	broad.mit.edu	37	chr12	51034594	51034594	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgctccctctaagtaccaccGaactcgatctgggggagcca	10	14	2	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr12:51034594G>A	uc001rwv.2	+	3	416	c.260G>A	c.(259-261)CGA>CAA	p.R87Q	DIP2B_uc001rwu.2_Missense_Mutation_p.R87Q|DIP2B_uc009zls.1_5'UTR	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	87						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						AAGTACCACCGAACTCGATCT	0.468													0	0	0	0.028581	0	15	28										A	51034594	G	A	51034594	3	1	17	1	0	0	0	0	1	0	0	0	4528	1058	37	1	270	1	DIP2B	12	51034594	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	1857890	51034594	82817301	75	4521										
PLXNC1	10154	broad.mit.edu	37	chr12	94648979	94648979	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgttttgcaggctttgctgaGctgcagatggataaattgga	13	5	0	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr12:94648979G>A	uc001tdc.2	+	17	3243	c.2994G>A	c.(2992-2994)GAG>GAA	p.E998E	PLXNC1_uc010sut.1_Silent_p.E45E	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	998	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						GCTTTGCTGAGCTGCAGATGG	0.393													0	0	0	0.006214	0	8	30										A	94648979	G	A	94648979	2	1	17	1	0	0	0	0	0	0	0	1	12126	962	34	2		2	PLXNC1	12	94648979	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	43614385	94648979	39202916	76	4522										
NCOR2	9612	broad.mit.edu	37	chr12	124824693	124824693	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggtgggcatgggagtgggagGcggggcggctgctgctgccc	23	9	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr12:124824693G>A	uc010tay.1	-	39	5732	c.5576C>T	c.(5575-5577)GCC>GTC	p.A1859V	NCOR2_uc010taz.1_Missense_Mutation_p.A1843V|NCOR2_uc010tax.1_5'UTR	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	1860					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGAGTGGGAGGCGGGgcggct	0.493													0	0	0	0.016522	0	25	45										A	124824693	G	A	124824693	3	1	17	1	0	0	0	0	1	0	0	0	10236	1203	42	2	2042	2	NCOR2	12	124824693	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	30175714	124824693	9027202	77	4523										
TMEM132D	121256	broad.mit.edu	37	chr12	130185155	130185155	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ttcaggaagaaggagacgtcCgcgttgttgatgtggtaggt	16	5	1	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr12:130185155C>T	uc009zyl.1	-	2	496	c.168G>A	c.(166-168)GCG>GCA	p.A56A		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	56	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGGAGACGTCCGCGTTGTTGA	0.562													0	0	0	0.006214	0	10	36										T	130185155	C	T	130185155	2	4	17	1	0	0	0	0	0	0	0	1	16044	639	23	2		2	TMEM132D	12	130185155	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	5360462	130185155	3666740	78	4524										
FNDC3A	22862	broad.mit.edu	37	chr13	49777357	49777357	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgggagtgtttacagccaatGaaaggtgatccagttattta	11	5	0	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr13:49777357G>T	uc001vcm.2	+	25	3524	c.3219G>T	c.(3217-3219)ATG>ATT	p.M1073I	FNDC3A_uc001vcn.2_Missense_Mutation_p.M1073I|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.M1017I	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1073	Fibronectin type-III 9.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACAGCCAATGAAAGGTGATC	0.328													1	0	9.16793e-09	0.0333	1.03813e-08	15	27										T	49777357	G	T	49777357	3	4	17	1	0	0	0	0	1	0	0	0	5969	1290	45	3	3324	3	FNDC3A	13	49777357	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		49777357	65392521	79	4525										
GPC5	2262	broad.mit.edu	37	chr13	92345539	92345539	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tggaggctgctgcttcggttCaggagttcttcactgatgtg	14	8	3	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr13:92345539C>A	uc010tif.1	+	3	790	c.424C>A	c.(424-426)CAG>AAG	p.Q142K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	142						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGCTTCGGTTCAGGAGTTCTT	0.408													1	0	2.27111e-07	0.013537	2.53443e-07	11	80										A	92345539	C	A	92345539	3	1	17	1	0	0	0	0	1	0	0	0	6601	827	29	3	434	3	GPC5	13	92345539	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	42568182	92345539	22824339	80	4526										
TUBGCP3	10426	broad.mit.edu	37	chr13	113181716	113181716	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	actgatccatcgtcataaacGaaggaatcatcgatttcctc	6	11	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr13:113181716G>A	uc001vse.1	-	12	1605	c.1418C>T	c.(1417-1419)TCG>TTG	p.S473L	TUBGCP3_uc010tjq.1_Missense_Mutation_p.S463L|TUBGCP3_uc001vsf.2_Missense_Mutation_p.S473L	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	473					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CGTCATAAACGAAGGAATCAT	0.368													0	0	0	0.021553	0	6	78										A	113181716	G	A	113181716	3	1	17	1	0	0	0	0	1	0	0	0	16764	1059	37	1	1349	1	TUBGCP3	13	113181716	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	20836177	113181716	1988162	81	4527										
AKAP6	9472	broad.mit.edu	37	chr14	33015022	33015022	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggactctcccacgcagcctaCattgccaaaaagaggacttt	8	13	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr14:33015022C>T	uc001wrq.2	+	4	1333	c.1163C>T	c.(1162-1164)ACA>ATA	p.T388I	AKAP6_uc010aml.2_Missense_Mutation_p.T385I	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	388					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACGCAGCCTACATTGCCAAAA	0.418													0	0	0	0.004482	0	9	47										T	33015022	C	T	33015022	3	4	17	1	0	0	0	0	1	0	0	0	455	478	17	2	1173	2	AKAP6	14	33015022	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		33015022	74334518	82	4528										
INSM2	84684	broad.mit.edu	37	chr14	36004658	36004658	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gagccaccgctgcctcagggCccctacacggagggggtgtt	15	14	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr14:36004658C>A	uc001wth.1	+	1	1411	c.1200C>A	c.(1198-1200)GGC>GGA	p.G400G		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		TGCCTCAGGGCCCCTACACGG	0.682													1	0	1.6384e-10	0.02938	1.88294e-10	7	70										A	36004658	C	A	36004658	2	1	17	1	0	0	0	0	0	0	0	1	7772	726	26	4		4	INSM2	14	36004658	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	2989636	36004658	71344882	83	4529										
FOXA1	3169	broad.mit.edu	37	chr14	38061857	38061858	+	Frame_Shift_Ins	INS	-	-	A													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tcatggtcatgtaggtgttcINSatggagttcatggagcccag							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr14:38061857_38061858insA	uc001wuf.2	-	2	443_444	c.131_132insT	c.(130-132)ATGfs	p.M44fs	FOXA1_uc010tpz.1_Frame_Shift_Ins_p.M11fs	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	44					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TGTAGGTGTTCATGGAGTTCAT	0.614																		18	96	---	---								A	38061858	-	A	38061857	7	5	17	1	0	1	1	0	0	0	0	0	5989	826	29	0	1290	0	FOXA1	14	38061857	Frame_Shift_Ins	INS	-	TCGA-BT-A2LD-01A-12D-A20D-08	2057199	38061857	69287683	84	4530										
GPR65	8477	broad.mit.edu	37	chr14	88477734	88477734	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctttagagaaatggcaaatCaacctcaacttgttcaggac	7	10	3	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr14:88477734C>G	uc001xvv.2	+	2	1073	c.543C>G	c.(541-543)ATC>ATG	p.I181M		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	181	Helical; Name=5; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						AATGGCAAATCAACCTCAACT	0.413													0	0	0	0.021553	0	5	92										G	88477734	C	G	88477734	3	3	17	1	0	0	0	0	1	0	0	0	6706	816	29	1	545	1	GPR65	14	88477734	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	50415877	88477734	18871806	85	4531										
CHAC1	79094	broad.mit.edu	37	chr15	41247690	41247690	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	accaaggaggtcaccttctaTccccaagatgctcctgacca	7	15	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr15:41247690T>C	uc001znh.2	+	3	533	c.513T>C	c.(511-513)TAT>TAC	p.Y171Y	CHAC1_uc010uct.1_Intron	NM_024111	NP_077016	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator-like 1 isoform	171					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TCACCTTCTATCCCCAAGATG	0.572													0	0	0	0.030593	0	27	215										C	41247690	T	C	41247690	2	2	17	1	0	0	0	0	0	0	0	1	3308	1442	50	5		5	CHAC1	15	41247690	Silent	SNP	T	TCGA-BT-A2LD-01A-12D-A20D-08		41247690	61283702	86	4532										
PLDN	26258	broad.mit.edu	37	chr15	45898644	45898644	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aaaaagaagagttggaaaggGagcagcaacgagagaaggag	16	3	0	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr15:45898644G>A	uc001zvq.2	+	5	676	c.451G>A	c.(451-453)GAG>AAG	p.E151K	PLDN_uc001zvr.2_RNA|PLDN_uc001zvs.2_RNA	NM_012388	NP_036520	Q9UL45	PLDN_HUMAN	pallidin	151	Potential.				post-Golgi vesicle-mediated transport|synaptic vesicle docking involved in exocytosis	BLOC-1 complex|endomembrane system|membrane	identical protein binding|syntaxin-13 binding			skin(1)	1		Lung NSC(122;1.6e-06)|all_lung(180;1.13e-05)|Melanoma(134;0.027)		all cancers(107;6.58e-18)|GBM - Glioblastoma multiforme(94;5.91e-07)		GTTGGAAAGGGAGCAGCAACG	0.398													0	0	0	0.004482	0	8	57										A	45898644	G	A	45898644	3	1	17	1	0	0	0	0	1	0	0	0	12051	1175	41	1	469	1	PLDN	15	45898644	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	4650954	45898644	56632748	87	4533										
CSNK1G1	53944	broad.mit.edu	37	chr15	64508801	64508801	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acaccgtcttcaaagtaaatGttcggtcacagaggtcaaac	8	10	4	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr15:64508801G>A	uc002anf.2	-	5	884	c.404C>T	c.(403-405)ACA>ATA	p.T135I	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Missense_Mutation_p.T135I|CSNK1G1_uc002anh.1_Missense_Mutation_p.T135I|CSNK1G1_uc002anj.2_Missense_Mutation_p.T108I	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	135	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						CAAAGTAAATGTTCGGTCACA	0.468													0	0	0	0.01892	0	21	25										A	64508801	G	A	64508801	3	1	17	1	0	0	0	0	1	0	0	0	3954	1377	48	2	896	2	CSNK1G1	15	64508801	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	18610157	64508801	38022591	88	4534										
IGDCC3	9543	broad.mit.edu	37	chr15	65625614	65625614	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccttgcaccaccagccggccCtgtgccgttctcctcacccg	8	21	2	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr15:65625614C>T	uc002aos.2	-	6	1215	c.963G>A	c.(961-963)CAG>CAA	p.Q321Q		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	321	Extracellular (Potential).|Ig-like C2-type 3.									ovary(3)	3						CCAGCCGGCCCTGTGCCGTTC	0.642													0	0	0	0.004482	0	8	84										T	65625614	C	T	65625614	2	4	17	1	0	0	0	0	0	0	0	1	7568	680	24	2		2	IGDCC3	15	65625614	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	1116813	65625614	36905778	89	4535										
LRRC49	54839	broad.mit.edu	37	chr15	71302263	71302263	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gaaatccagttgtcaattttAcactctggaaatactatgta	6	7	2	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr15:71302263A>G	uc002asw.2	+	13	1772	c.1525A>G	c.(1525-1527)ACA>GCA	p.T509A	LRRC49_uc002asu.2_Missense_Mutation_p.T499A|LRRC49_uc002asx.2_Missense_Mutation_p.T465A|LRRC49_uc010ukf.1_Missense_Mutation_p.T514A|LRRC49_uc002asy.2_Missense_Mutation_p.T215A|LRRC49_uc002asz.2_Missense_Mutation_p.T481A	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	509						cytoplasm|microtubule				ovary(1)	1						TGTCAATTTTACACTCTGGAA	0.363													0	0	0	0.02938	0	6	35										G	71302263	A	G	71302263	3	3	17	1	0	0	0	0	1	0	0	0	9006	391	14	5	1575	5	LRRC49	15	71302263	Missense_Mutation	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	5676649	71302263	31229129	90	4536										
RHBDF1	64285	broad.mit.edu	37	chr16	113739	113739	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgcagtgacggatgctcttgCgctgccatttctgggtgctg	14	10	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:113739C>T	uc002cfl.3	-	7	456	c.308G>A	c.(307-309)CGC>CAC	p.R103H	RHBDF1_uc010uty.1_Missense_Mutation_p.R126H|RHBDF1_uc010utz.1_Missense_Mutation_p.R103H|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	103	Cytoplasmic (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				GATGCTCTTGCGCTGCCATTT	0.657													0	0	0	0.004482	0	7	51										T	113739	C	T	113739	3	4	17	1	0	0	0	0	1	0	0	0	13319	768	27	2	2319	2	RHBDF1	16	113739	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		113739	90241014	91	4537										
GRIN2A	2903	broad.mit.edu	37	chr16	9916174	9916174	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctttctgattaaatttggtCatgtactgatgcatgtaggg	10	6	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:9916174C>G	uc002czo.3	-	10	2663	c.2115G>C	c.(2113-2115)ATG>ATC	p.M705I	GRIN2A_uc010uym.1_Missense_Mutation_p.M705I|GRIN2A_uc010uyn.1_Missense_Mutation_p.M548I|GRIN2A_uc002czr.3_Missense_Mutation_p.M705I	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	705	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAAATTTGGTCATGTACTGAT	0.468													0	0	0	0.006214	0	9	74										G	9916174	C	G	9916174	3	3	17	1	0	0	0	0	1	0	0	0	6779	826	29	1	2295	1	GRIN2A	16	9916174	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	9802435	9916174	80438579	92	4538										
SNX29	92017	broad.mit.edu	37	chr16	12223537	12223537	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ggagcactcagccgcgctccGgcaagaggtggacaccttga	14	13	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:12223537G>A	uc002dby.3	+	6	418	c.362G>A	c.(361-363)CGG>CAG	p.R121Q	SNX29_uc010uyx.1_Missense_Mutation_p.R148Q	NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	121	Potential.				cell communication		phosphatidylinositol binding			ovary(1)	1						GCCGCGCTCCGGCAAGAGGTG	0.607													0	0	0	0.00308	0	7	20										A	12223537	G	A	12223537	3	1	17	1	0	0	0	0	1	0	0	0	14898	1116	39	2	380	2	SNX29	16	12223537	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	2307363	12223537	78131216	93	4539										
SRCAP	10847	broad.mit.edu	37	chr16	30718977	30718977	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aggagcaggccaagctgcgtCgaattgcttccaccatggcc	12	13	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:30718977C>T	uc002dze.1	+	6	962	c.577C>T	c.(577-579)CGA>TGA	p.R193*	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Nonsense_Mutation_p.R50*|SRCAP_uc010bzz.1_5'Flank|SNORA30_uc002dzh.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	193	HSA.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CAAGCTGCGTCGAATTGCTTC	0.572													0	0	0	0.028581	0	15	57										T	30718977	C	T	30718977	4	4	17	1	0	0	0	0	0	1	0	0	15134	876	31	1	591	1	SRCAP	16	30718977	Nonsense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	18495440	30718977	59635776	94	4540										
SRCAP	10847	broad.mit.edu	37	chr16	30720939	30720939	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctgaaaagtactcggaccttCtgtctcagagcctcaaccag	8	13	3	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:30720939C>T	uc002dze.1	+	7	1124	c.739C>T	c.(739-741)CTG>TTG	p.L247L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.L104L|SRCAP_uc010bzz.1_5'Flank|SNORA30_uc002dzh.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	247					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTCGGACCTTCTGTCTCAGAG	0.547													0	0	0	0.012213	0	32	92										T	30720939	C	T	30720939	2	4	17	1	0	0	0	0	0	0	0	1	15134	912	32	1		1	SRCAP	16	30720939	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	1962	30720939	59633814	95	4541										
RNF40	9810	broad.mit.edu	37	chr16	30774850	30774850	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	caacatgtgatgggactcctCtcccagagccggggacatca	11	13	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:30774850C>G	uc002dzq.2	+	4	535	c.412C>G	c.(412-414)CTC>GTC	p.L138V	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Missense_Mutation_p.L138V|RNF40_uc010cab.2_Missense_Mutation_p.L138V|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.L138V|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	138					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			TGGGACTCCTCTCCCAGAGCC	0.617													0	0	0	0.006122	0	19	46										G	30774850	C	G	30774850	3	3	17	1	0	0	0	0	1	0	0	0	13493	913	32	1	422	1	RNF40	16	30774850	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	53911	30774850	59579903	96	4542										
CKLF	51192	broad.mit.edu	37	chr16	66592158	66592158	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cctgaaccatatattgttatCactggatttgaagtcaccgt	7	9	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:66592158C>T	uc002eow.2	+	2	291	c.144C>T	c.(142-144)ATC>ATT	p.I48I	CKLF_uc002eox.1_Silent_p.I48I|CKLF_uc002eot.2_Silent_p.I48I|CKLF_uc002eou.2_Intron|CKLF_uc002eov.2_Intron	NM_016951	NP_058647	Q9UBR5	CKLF_HUMAN	chemokine-like factor isoform a	48	Helical; (Potential).|MARVEL.				cell proliferation|lymphocyte chemotaxis|macrophage chemotaxis|neutrophil chemotaxis|secretion by cell	extracellular space|integral to membrane	chemokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0689)|Epithelial(162;0.217)		ATATTGTTATCACTGGATTTG	0.353													0	0	0	0.008291	0	10	51										T	66592158	C	T	66592158	2	4	17	1	0	0	0	0	0	0	0	1	3447	816	29	1		1	CKLF	16	66592158	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	35817308	66592158	23762595	97	4543										
TMED6	146456	broad.mit.edu	37	chr16	69385672	69385672	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gacatgccgctttctggagcCtcctctgcaggtgaactgct	11	13	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:69385672C>A	uc002exc.1	-	1	18	c.-15G>T	c.(-17--13)GAGGC>GATGC			NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain						transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						TTTCTGGAGCCTCCTCTGCAG	0.537													1	0	0.00448238	0.004482	0.00479366	8	32										A	69385672	C	A	69385672	1	1	17	1	0	0	0	0	0	0	0	0	16005	696	24	4		4	TMED6	16	69385672	Translation_Start_Site	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	2793514	69385672	20969081	98	4544										
C16orf7	9605	broad.mit.edu	37	chr16	89774351	89774351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgaggcagtagccctcctctCcgatcaggtacctgcatgga	11	13	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr16:89774351C>T	uc002fom.1	-	15	1939	c.1814G>A	c.(1813-1815)GGA>GAA	p.G605E	C16orf7_uc002fol.1_Missense_Mutation_p.G535E	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	605	VPS9.				ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GCCCTCCTCTCCGATCAGGTA	0.622													0	0	0	0.024245	0	11	77										T	89774351	C	T	89774351	3	4	17	1	0	0	0	0	1	0	0	0	1828	855	30	1	85	1	C16orf7	16	89774351	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	20388679	89774351	580402	99	4545										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	54	34										T	7577538	C	T	7577538	3	4	17	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		7577538	73617672	100	4546										
GUCY2D	3000	broad.mit.edu	37	chr17	7917216	7917216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	agaagtggtgcagagggtgcGgagcccccctccactgtgtc	15	12	0	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr17:7917216G>A	uc002gjt.2	+	12	2356	c.2282G>A	c.(2281-2283)CGG>CAG	p.R761Q		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	761	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CAGAGGGTGCGGAGCCCCCCT	0.622													0	0	0	0.024245	0	15	148										A	7917216	G	A	7917216	3	1	17	1	0	0	0	0	1	0	0	0	6897	1116	39	2	2324	2	GUCY2D	17	7917216	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	339678	7917216	73277994	101	4547										
RAPGEFL1	51195	broad.mit.edu	37	chr17	38347663	38347663	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cgctgcagcgaggtcacgcaCtgggtggccaccgaagtgct	15	13	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr17:38347663C>T	uc010cwu.1	+	9	1303	c.813C>T	c.(811-813)CAC>CAT	p.H271H	RAPGEFL1_uc010wfd.1_Silent_p.H207H	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	477	Ras-GEF.				G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AGGTCACGCACTGGGTGGCCA	0.682													0	0	0	0.020292	0	12	22										T	38347663	C	T	38347663	2	4	17	1	0	0	0	0	0	0	0	1	13049	564	20	2		2	RAPGEFL1	17	38347663	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	30430447	38347663	42847547	102	4548										
KRTAP4-11	653240	broad.mit.edu	37	chr17	39274427	39274427	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	cactggggcctgcagcagctGgacacacagcagctggggcg	16	13	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr17:39274427G>A	uc002hvz.2	-	1	180	c.141C>T	c.(139-141)TCC>TCT	p.S47S		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	47	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].|5.		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGCAGCAGCTGGACACACAGC	0.677													0	0	0	0.0333	0	14	194										A	39274427	G	A	39274427	2	1	17	1	0	0	0	0	0	0	0	1	8549	1335	47	2		2	KRTAP4-11	17	39274427	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	926764	39274427	41920783	103	4549										
FAM104A	84923	broad.mit.edu	37	chr17	71223344	71223346	+	In_Frame_Del	DEL	CTT	CTT	-													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gaaagacagggtttctgctaCttcttttggtctggggggga							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr17:71223344_71223346delCTT	uc002jji.3	-	2	367_369	c.279_281delAAG	c.(277-282)AGAAGT>AGT	p.R93del	FAM104A_uc002jjj.3_In_Frame_Del_p.R93del	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	93											0			LUSC - Lung squamous cell carcinoma(166;0.197)			GTTTCTGCTACTTCTTTTGGTCT	0.409																		7	66	---	---								-	71223346	CTT	-	71223344	7	5	17	1	0	1	0	1	0	0	0	0	5385	565	20	0	354	0	FAM104A	17	71223344	In_Frame_Del	DEL	CTT	TCGA-BT-A2LD-01A-12D-A20D-08	31948917	71223344	9971866	104	4550										
DTNA	1837	broad.mit.edu	37	chr18	32418763	32418763	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gctgatgaacatgttctcatCgggttgtatgtcaacatgct	10	8	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr18:32418763C>T	uc010dmn.1	+	12	1228	c.1227C>T	c.(1225-1227)ATC>ATT	p.I409I	DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Intron|DTNA_uc002kxw.2_Intron|DTNA_uc010dmj.2_Intron|DTNA_uc002kxz.2_Intron|DTNA_uc002kxy.2_Intron|DTNA_uc010dml.2_Intron|DTNA_uc002kyb.3_Silent_p.I406I|DTNA_uc010dmm.2_Silent_p.I409I|DTNA_uc010xby.1_Intron|DTNA_uc010dmo.2_Intron|DTNA_uc002kyd.3_Intron|DTNA_uc010xbz.1_Silent_p.I118I|DTNA_uc010xca.1_Intron|DTNA_uc002kye.2_Intron	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	409	Syntrophin-binding region.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						ATGTTCTCATCGGGTTGTATG	0.502													0	0	0	0.021553	0	6	83										T	32418763	C	T	32418763	2	4	17	1	0	0	0	0	0	0	0	1	4788	874	31	1		1	DTNA	18	32418763	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		32418763	45658485	105	4551										
SMAD7	4092	broad.mit.edu	37	chr18	46448082	46448082	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgccgcagccgattttgctcCgcaccttctgcaccagctga	9	16	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr18:46448082C>T	uc002ldg.2	-	4	1228	c.941G>A	c.(940-942)CGG>CAG	p.R314Q	SMAD7_uc002ldf.2_Missense_Mutation_p.R126Q|SMAD7_uc010xde.1_Missense_Mutation_p.R99Q	NM_005904	NP_005895	O15105	SMAD7_HUMAN	SMAD family member 7	314	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding				0	Colorectal(1;0.0518)					GATTTTGCTCCGCACCTTCTG	0.557													0	0	0	0.012319	0	21	60										T	46448082	C	T	46448082	3	4	17	1	0	0	0	0	1	0	0	0	14763	652	23	2	343	2	SMAD7	18	46448082	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	14029319	46448082	31629166	106	4552										
CXXC1	30827	broad.mit.edu	37	chr18	47812525	47812525	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gatcagggacaggcctcttgCgccctccaccctcatcccgg	10	18	3	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr18:47812525C>T	uc002leq.3	-	4	1059	c.326G>A	c.(325-327)CGC>CAC	p.R109H	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Missense_Mutation_p.R109H|CXXC1_uc010doy.2_Missense_Mutation_p.R109H|CXXC1_uc002les.2_Missense_Mutation_p.R109H	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	109					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						AGGCCTCTTGCGCCCTCCACC	0.642													0	0	0	0.01441	0	56	126										T	47812525	C	T	47812525	3	4	17	1	0	0	0	0	1	0	0	0	4097	768	27	2	1704	2	CXXC1	18	47812525	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	1364443	47812525	30264723	107	4553										
DOK6	220164	broad.mit.edu	37	chr18	67365704	67365704	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tatggtgaatgcacaatgcaGatcactcatgaaaatatcta	7	7	3	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr18:67365704G>A	uc002lkl.2	+	5	664	c.474G>A	c.(472-474)CAG>CAA	p.Q158Q		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	158	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GCACAATGCAGATCACTCATG	0.438													0	0	0	0.006122	0	17	46										A	67365704	G	A	67365704	2	1	17	1	0	0	0	0	0	0	0	1	4701	933	33	1		1	DOK6	18	67365704	Silent	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	19553179	67365704	10711544	108	4554										
SMARCA4	6597	broad.mit.edu	37	chr19	11141426	11141426	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gaaccacgaaggcggaggacCggggcatgctgctgaaaacc	15	11	0	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:11141426C>T	uc002mqf.3	+	25	3687	c.3403C>T	c.(3403-3405)CGG>TGG	p.R1135W	SMARCA4_uc010dxp.2_Missense_Mutation_p.R1135W|SMARCA4_uc010dxo.2_Missense_Mutation_p.R1135W|SMARCA4_uc002mqg.1_Missense_Mutation_p.R1135W|SMARCA4_uc010dxq.2_Missense_Mutation_p.R1135W|SMARCA4_uc010dxr.2_Missense_Mutation_p.R1135W|SMARCA4_uc002mqj.3_Missense_Mutation_p.R1135W|SMARCA4_uc010dxs.2_Missense_Mutation_p.R1135W|SMARCA4_uc010dxt.1_Missense_Mutation_p.R355W|SMARCA4_uc002mqh.3_Missense_Mutation_p.R258W|SMARCA4_uc002mqi.1_Missense_Mutation_p.R338W	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1135	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGCGGAGGACCGGGGCATGCT	0.632			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.014758	0	4	27										T	11141426	C	T	11141426	3	4	17	1	0	0	0	0	1	0	0	0	14770	643	23	2	3497	2	SMARCA4	19	11141426	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		11141426	47987557	109	4555										
ANO8	57719	broad.mit.edu	37	chr19	17435648	17435648	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	catctggccgggcctgcccgCccgccccgttggacccaggc	13	20	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:17435648C>T	uc002ngf.2	-	17	3368	c.3209G>A	c.(3208-3210)GGC>GAC	p.G1070D	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	1070	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(3)	3						GGCCTGCCCGCCCGCCCCGTT	0.711													0	0	0	0.024245	0	15	99										T	17435648	C	T	17435648	3	4	17	1	0	0	0	0	1	0	0	0	703	739	26	2	497	2	ANO8	19	17435648	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	6294222	17435648	41693335	110	4556										
TSHZ3	57616	broad.mit.edu	37	chr19	31770237	31770237	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ccacagctgctgctgctgctActgctgctgctgctgctgcc	11	16	0	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:31770237A>G	uc002nsy.3	-	2	527	c.462T>C	c.(460-462)AGT>AGC	p.S154S		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	154	Ser-rich.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					tgctgctgctactgctgctgc	0.448													0	0	0	0.00308	0	6	265										G	31770237	A	G	31770237	2	3	17	1	0	0	0	0	0	0	0	1	16622	388	14	5		5	TSHZ3	19	31770237	Silent	SNP	A	TCGA-BT-A2LD-01A-12D-A20D-08	14334589	31770237	27358746	111	4557										
CD22	933	broad.mit.edu	37	chr19	35837577	35837577	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctcaggcacaagaaaatgtgGactatgtgatcctcaaacat	8	9	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:35837577G>A	uc010edt.2	+	14	2598	c.2521G>A	c.(2521-2523)GAC>AAC	p.D841N	CD22_uc010xst.1_Missense_Mutation_p.D669N|CD22_uc010edu.2_Missense_Mutation_p.D753N|CD22_uc010edv.2_3'UTR|CD22_uc002nzb.3_Missense_Mutation_p.D664N|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	841	ITIM motif 4.|Cytoplasmic (Potential).				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AGAAAATGTGGACTATGTGAT	0.562													0	0	0	0.004482	0	8	13										A	35837577	G	A	35837577	3	1	17	1	0	0	0	0	1	0	0	0	2985	1174	41	1	2571	1	CD22	19	35837577	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	4067340	35837577	23291406	112	4558										
ZFP82	284406	broad.mit.edu	37	chr19	36896541	36896541	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gctcttttccttgctccaatGaggaaatcacatctggttta	7	10	3	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:36896541G>A	uc002ody.1	-	4	405	c.170C>T	c.(169-171)TCA>TTA	p.S57L		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TTGCTCCAATGAGGAAATCAC	0.383													0	0	0	0.01441	0	62	101										A	36896541	G	A	36896541	3	1	17	1	0	0	0	0	1	0	0	0	17650	1294	45	1	1436	1	ZFP82	19	36896541	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	1058964	36896541	22232442	113	4559										
ZNF529	57711	broad.mit.edu	37	chr19	37037947	37037947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	acatgccttgcattcataggGtttttctccagtatgaattc	7	9	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:37037947G>A	uc002oeh.3	-	5	1715	c.1513C>T	c.(1513-1515)CCC>TCC	p.P505S	ZNF529_uc010xth.1_Missense_Mutation_p.P505S|ZNF529_uc010xti.1_Missense_Mutation_p.P487S|ZNF529_uc002oeg.3_Missense_Mutation_p.P400S	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					CATTCATAGGGTTTTTCTCCA	0.403													0	0	0	0.009096	0	4	19										A	37037947	G	A	37037947	3	1	17	1	0	0	0	0	1	0	0	0	17967	1261	44	2	182	2	ZNF529	19	37037947	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	141406	37037947	22091036	114	4560										
IRF2BP1	26145	broad.mit.edu	37	chr19	46388156	46388157	+	Frame_Shift_Ins	INS	-	-	CA													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tcgtggaacatctggcgagcINScactgccaggacgccggcgt							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:46388156_46388157insCA	uc002pds.1	-	1	1220_1221	c.876_877insTG	c.(874-879)GTGGCTfs	p.V292fs		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	292_293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		ATCTGGCGAGCCACTGCCAGGA	0.594																		9	126	---	---								CA	46388157	-	CA	46388156	7	5	17	1	0	1	1	0	0	0	0	0	7829	739	26	0	881	0	IRF2BP1	19	46388156	Frame_Shift_Ins	INS	-	TCGA-BT-A2LD-01A-12D-A20D-08	9350209	46388156	12740827	115	4561										
SIGLEC12	89858	broad.mit.edu	37	chr19	52002805	52002805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gtgggatgaggctgagcatcGaggagcgagtgatagtgggg	21	4	0	3	rs149053840		TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:52002805G>A	uc002pwx.1	-	3	1030	c.974C>T	c.(973-975)TCG>TTG	p.S325L	SIGLEC12_uc002pww.1_Missense_Mutation_p.S207L|SIGLEC12_uc010eoy.1_Missense_Mutation_p.S52L	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	325	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GCTGAGCATCGAGGAGCGAGT	0.667													0	0	0	0.010729	0	12	89										A	52002805	G	A	52002805	3	1	17	1	0	0	0	0	1	0	0	0	14308	1059	37	1	837	1	SIGLEC12	19	52002805	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	5614649	52002805	7126178	116	4562										
ZNF471	57573	broad.mit.edu	37	chr19	57035702	57035702	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	atatctttcagattgggaatCtatatatgtgacacaggaat	8	5	3	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:57035702C>T	uc002qnh.2	+	5	399	c.266C>T	c.(265-267)TCT>TTT	p.S89F		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		GATTGGGAATCTATATATGTG	0.333													0	0	0	0.024245	0	13	72										T	57035702	C	T	57035702	3	4	17	1	0	0	0	0	1	0	0	0	17927	913	32	1	280	1	ZNF471	19	57035702	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	5032897	57035702	2093281	117	4563										
ZNF586	54807	broad.mit.edu	37	chr19	58290574	58290574	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	actctggagcaaagcgttatGaatgcaatgaatgtgggaag	13	5	1	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:58290574G>C	uc002qqd.2	+	3	805	c.619G>C	c.(619-621)GAA>CAA	p.E207Q	ZNF587_uc002qqb.2_Intron|ZNF586_uc002qqe.2_Missense_Mutation_p.M164I|ZNF586_uc010euh.2_Missense_Mutation_p.E164Q|ZNF586_uc002qqf.1_Intron	NM_017652	NP_060122	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	207	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAGCGTTATGAATGCAATGA	0.428													0	0	0	0.02938	0	7	150										C	58290574	G	C	58290574	3	2	17	1	0	0	0	0	1	0	0	0	18016	1291	45	1	629	1	ZNF586	19	58290574	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	1254872	58290574	838409	118	4564										
ZNF586	54807	broad.mit.edu	37	chr19	58290633	58290633	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	agtctcattaaacacaggagGattcacactggagagaggcc	11	9	2	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr19:58290633G>C	uc002qqd.2	+	3	864	c.678G>C	c.(676-678)AGG>AGC	p.R226S	ZNF587_uc002qqb.2_Intron|ZNF586_uc002qqe.2_Missense_Mutation_p.G184A|ZNF586_uc010euh.2_Missense_Mutation_p.R183S|ZNF586_uc002qqf.1_Intron	NM_017652	NP_060122	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	226	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AACACAGGAGGATTCACACTG	0.418													0	0	0	0.010729	0	10	157										C	58290633	G	C	58290633	3	2	17	1	0	0	0	0	1	0	0	0	18016	1165	41	1	688	1	ZNF586	19	58290633	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	59	58290633	838350	119	4565										
KIF16B	55614	broad.mit.edu	37	chr20	16359928	16359928	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	caggaggtactgtagctggcGttctttatattgcagcctgt	12	8	1	0			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr20:16359928G>A	uc002wpg.1	-	19	2877	c.2719C>T	c.(2719-2721)CGC>TGC	p.R907C	KIF16B_uc002wpe.1_Missense_Mutation_p.R289C|KIF16B_uc002wpf.1_Missense_Mutation_p.R289C|KIF16B_uc010gch.1_Missense_Mutation_p.R907C|KIF16B_uc010gci.1_Missense_Mutation_p.R907C|KIF16B_uc010gcj.1_Missense_Mutation_p.R918C	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	907	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TGTAGCTGGCGTTCTTTATAT	0.438													0	0	0	0.021553	0	4	63										A	16359928	G	A	16359928	3	1	17	1	0	0	0	0	1	0	0	0	8278	1145	40	2	1266	2	KIF16B	20	16359928	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		16359928	46665592	120	4566										
ASXL1	171023	broad.mit.edu	37	chr20	31021631	31021631	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	aaaagaagccccggcttgaaGatcgtcagtcctttcgtaac	9	11	1	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr20:31021631G>A	uc002wxs.2	+	11	2056	c.1630G>A	c.(1630-1632)GAT>AAT	p.D544N	ASXL1_uc010geb.2_Missense_Mutation_p.D435N	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	544					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CCGGCTTGAAGATCGTCAGTC	0.532			F|N|Mis		MDS|CMML								0	0	0	0.013537	0	13	209										A	31021631	G	A	31021631	3	1	17	1	0	0	0	0	1	0	0	0	1066	942	33	1	1682	1	ASXL1	20	31021631	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08	14661703	31021631	32003889	121	4567										
ZNF341	84905	broad.mit.edu	37	chr20	32371588	32371589	+	Frame_Shift_Ins	INS	-	-	G													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	atctgcccacccacggcagcINSgggggcaggttcaagtgcca					rs139829835		TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr20:32371588_32371589insG	uc002wzy.2	+	12	1790_1791	c.1770_1771insG	c.(1768-1773)AGCGGGfs	p.S590fs	ZNF341_uc002wzx.2_Frame_Shift_Ins_p.S583fs|ZNF341_uc010geq.2_Frame_Shift_Ins_p.S500fs|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	590_591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCCACGGCAGCGGGGGCAGGTT	0.614																		11	163	---	---								G	32371589	-	G	32371588	7	5	17	1	0	1	1	0	0	0	0	0	17854	767	27	0	1795	0	ZNF341	20	32371588	Frame_Shift_Ins	INS	-	TCGA-BT-A2LD-01A-12D-A20D-08	1349957	32371588	30653932	122	4568										
ZNFX1	57169	broad.mit.edu	37	chr20	47863986	47863986	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctccatggctcccccacaatCgccaatcacatagatatggc	6	16	1	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr20:47863986C>T	uc002xui.2	-	14	5822	c.5575G>A	c.(5575-5577)GAT>AAT	p.D1859N		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1859							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCCCCACAATCGCCAATCACA	0.517													0	0	0	0.01441	0	52	114										T	47863986	C	T	47863986	3	4	17	1	0	0	0	0	1	0	0	0	18202	884	31	1	185	1	ZNFX1	20	47863986	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	15492398	47863986	15161534	123	4569										
NCAM2	4685	broad.mit.edu	37	chr21	22696785	22696785	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	atgacattttcctgcagggcCtcaggctctccagaacccgc	9	15	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr21:22696785C>A	uc002yld.1	+	6	951	c.702C>A	c.(700-702)GCC>GCA	p.A234A	NCAM2_uc011acb.1_Silent_p.A92A|NCAM2_uc011acc.1_Silent_p.A259A	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	234	Ig-like C2-type 3.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CCTGCAGGGCCTCAGGCTCTC	0.507													1	0	5.18039e-06	0.00308	5.73943e-06	7	107										A	22696785	C	A	22696785	2	1	17	1	0	0	0	0	0	0	0	1	10203	668	24	4		4	NCAM2	21	22696785	Silent	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		22696785	25433110	124	4570										
PRR5-ARHGAP8	553158	broad.mit.edu	37	chr22	45130923	45130923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gcagggggtacatgagtccaGgggcgtgactgaggactacc	17	9	0	3			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chr22:45130923G>A	uc003bfd.2	+	7	844	c.572G>A	c.(571-573)AGG>AAG	p.R191K	PRR5_uc003bew.1_Missense_Mutation_p.R182K|PRR5_uc003bex.1_Missense_Mutation_p.R96K|PRR5_uc010gzt.1_Missense_Mutation_p.R214K|PRR5_uc010gzu.1_Missense_Mutation_p.R155K|PRR5_uc003bey.1_Missense_Mutation_p.R182K|PRR5_uc003bez.1_Missense_Mutation_p.R96K|PRR5-ARHGAP8_uc003bfc.2_Intron|PRR5-ARHGAP8_uc011aqi.1_Intron|PRR5-ARHGAP8_uc011aqj.1_Intron|PRR5_uc003bfa.1_Missense_Mutation_p.R84K|PRR5_uc003bfb.1_Missense_Mutation_p.R191K|PRR5_uc003bfe.1_Intron|PRR5-ARHGAP8_uc003bfg.1_Intron|PRR5_uc003bfh.1_Missense_Mutation_p.R90K	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						CATGAGTCCAGGGGCGTGACT	0.652													0	0	0	0.02938	0	7	59										A	45130923	G	A	45130923	3	1	17	1	0	0	0	0	1	0	0	0	12601	1000	35	2		2	PRR5-ARHGAP8	22	45130923	Missense_Mutation	SNP	G	TCGA-BT-A2LD-01A-12D-A20D-08		45130923	6173643	125	4571										
ACE2	59272	broad.mit.edu	37	chrX	15605982	15605982	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	tgttcatataatggtttaatCtgaaaagcccaggaagaaag	9	5	2	2			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chrX:15605982C>A	uc004cxa.1	-	6	865	c.697_splice	c.e6-1	p.I233_splice	ACE2_uc004cxb.2_Splice_Site_p.I233_splice	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor						angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	ATGGTTTAATCTGAAAAGCCC	0.368													1	0	2.32078e-09	0.024245	2.64741e-09	14	16										A	15605982	C	A	15605982	5	1	17	1	0	0	0	0	0	0	1	0	137	927	32	3	1773	3	ACE2	23	15605982	Splice_Site	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08		15605982	139664578	126	4572										
YY2	404281	broad.mit.edu	37	chrX	21863399	21863399	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	gatggctgactctccctcttCttattcttcctcctcttctt	4	15	6	1			TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chrX:21863399C>T	uc010nfq.2	+	3	532	c.335C>T	c.(334-336)TCT>TTT	p.S112F	MBTPS2_uc004dae.2_Missense_Mutation_p.S112F|MBTPS2_uc004dab.2_Missense_Mutation_p.S112F	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						tctccctcttcttattcttcc	0.249													0	0	0	0.006214	0	8	60										T	21863399	C	T	21863399	3	4	17	1	0	0	0	0	1	0	0	0	17506	913	32	1		1	YY2	23	21863399	Missense_Mutation	SNP	C	TCGA-BT-A2LD-01A-12D-A20D-08	6257417	21863399	133407161	127	4573										
KDM6A	7403	broad.mit.edu	37	chrX	44833924	44833924	+	Frame_Shift_Del	DEL	C	C	-													0.1875	24	0.000344709565868183	2.13822629969419	5.83152627189324	1.62396934153989	0.054211061962268	0.140948761101897	13	ctttcagcattatctgcataCcagaggtactacagtttaca							TCGA-BT-A2LD-01A-12D-A20D-08	TCGA-BT-A2LD-10A-01D-A20D-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	cc95719c-7fcc-4ed7-837e-1840c0a6bc27	c8dad5de-60a0-4dec-9529-5c70a6216491	g.chrX:44833924delC	uc004dge.3	+	4	723	c.348delC	c.(346-348)TACfs	p.Y116fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.Y116fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.Y116fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.Y116fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.Y116fs|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	116	TPR 1.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATCTGCATACCAGAGGTACT	0.348			D|N|F|S		renal|oesophageal SCC|MM													23	21	---	---								-	44833924	C	-	44833924	7	5	17	1	0	1	0	1	0	0	0	0	8137	518	18	0	362	0	KDM6A	23	44833924	Frame_Shift_Del	DEL	C	TCGA-BT-A2LD-01A-12D-A20D-08	22970525	44833924	110436636	128	4574										
CDK11B	984	broad.mit.edu	37	chr1	1572548	1572548	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccacgcagcagctggatcatCagggtcttcacctcccctgg	10	16	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:1572548C>G	uc001agv.1	-	19	1698	c.1587G>C	c.(1585-1587)CTG>CTC	p.L529L	CDK11B_uc009vkj.2_Silent_p.L186L|CDK11B_uc001ags.1_Silent_p.L387L|CDK11B_uc001agt.1_Silent_p.L312L|CDK11B_uc001aha.1_Silent_p.L495L|CDK11B_uc001agw.1_Silent_p.L484L|CDK11B_uc001agy.1_Silent_p.L527L|CDK11B_uc001agx.1_Silent_p.L518L|CDK11B_uc001agz.1_Silent_p.L273L	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	542	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						GCTGGATCATCAGGGTCTTCA	0.652													0	0	0	1	0	6	88										G	1572548	C	G	1572548	2	3	18	1	0	0	0	0	0	0	0	1	3127	813	29	1		1	CDK11B	1	1572548	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		1572548	247678073	1	4575										
CDK11A	728642	broad.mit.edu	37	chr1	1635767	1635767	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccccgcagcagctggatcatCagggtcttcacctcccctgg	10	17	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:1635767C>G	uc009vks.2	-	15	1689	c.1581G>C	c.(1579-1581)CTG>CTC	p.L527L	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Silent_p.L34L|CDK11A_uc009vkp.2_Silent_p.L144L|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Silent_p.L517L|CDK11A_uc010nys.1_3'UTR	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	530	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GCTGGATCATCAGGGTCTTCA	0.672													0	0	0	1	0	10	36										G	1635767	C	G	1635767	2	3	18	1	0	0	0	0	0	0	0	1	3126	813	29	1		1	CDK11A	1	1635767	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	63219	1635767	247614854	2	4576										
MEGF6	1953	broad.mit.edu	37	chr1	3511904	3511904	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcgcaggcggcactcacccGagaggcagccctcctcgtcg	14	17	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:3511904G>C	uc001akl.2	-	3	601	c.374C>G	c.(373-375)TCG>TGG	p.S125W		NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	125	EGF-like 1.|EMI.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCACTCACCCGAGAGGCAGCC	0.682													0	0	0	1	0	40	39										C	3511904	G	C	3511904	3	2	18	1	0	0	0	0	1	0	0	0	9462	1059	37	1	4391	1	MEGF6	1	3511904	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1876137	3511904	245738717	3	4577										
KIF1B	23095	broad.mit.edu	37	chr1	10342591	10342591	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaagctattgaacgtttaaaGgtaagtaatagttcagactg	10	4	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:10342591G>A	uc001aqx.3	+	15	1636	c.1434G>A	c.(1432-1434)AAG>AAA	p.K478K	KIF1B_uc001aqv.3_Silent_p.K432K|KIF1B_uc001aqw.3_Silent_p.K432K|KIF1B_uc001aqy.2_Silent_p.K452K|KIF1B_uc001aqz.2_Silent_p.K478K|KIF1B_uc001ara.2_Silent_p.K438K|KIF1B_uc001arb.2_Silent_p.K464K	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	478	Potential.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AACGTTTAAAGGTAAGTAATA	0.294													0	0	0	1	0	41	89										A	10342591	G	A	10342591	2	1	18	1	0	0	0	0	0	0	0	1	8284	1014	35	2		2	KIF1B	1	10342591	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6830687	10342591	238908030	4	4578										
FBXO2	26232	broad.mit.edu	37	chr1	11708844	11708844	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccccgtgctcgaagcggacGaagcggacgcccggcccgta	14	17	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:11708844G>A	uc001asj.2	-	6	1140	c.798C>T	c.(796-798)TTC>TTT	p.F266F	FBXO2_uc009vna.2_Silent_p.F269F	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	266	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CGAAGCGGACGAAGCGGACGC	0.677													0	0	0	1	0	137	103										A	11708844	G	A	11708844	2	1	18	1	0	0	0	0	0	0	0	1	5732	1049	37	1		1	FBXO2	1	11708844	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1366253	11708844	237541777	5	4579										
VPS13D	55187	broad.mit.edu	37	chr1	12337497	12337497	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctaaacaggagtgttttctCaacctgaagatggcttcttt	8	8	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:12337497C>G	uc001atv.2	+	19	3993	c.3852C>G	c.(3850-3852)CTC>CTG	p.L1284L	VPS13D_uc001atw.2_Silent_p.L1284L|VPS13D_uc001atx.2_Silent_p.L472L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1284					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGTGTTTTCTCAACCTGAAGA	0.398													0	0	0	1	0	125	134										G	12337497	C	G	12337497	2	3	18	1	0	0	0	0	0	0	0	1	17189	813	29	1		1	VPS13D	1	12337497	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	628653	12337497	236913124	6	4580										
UBR4	23352	broad.mit.edu	37	chr1	19477120	19477120	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggggcagctgagtcgctatCtccagtgccgttgctctggt	15	11	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:19477120C>T	uc001bbi.2	-	49	7385	c.7381G>A	c.(7381-7383)GAT>AAT	p.D2461N	UBR4_uc001bbk.1_Missense_Mutation_p.D115N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2461					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GAGTCGCTATCTCCAGTGCCG	0.547													0	0	0	1	0	203	205										T	19477120	C	T	19477120	3	4	18	1	0	0	0	0	1	0	0	0	16901	913	32	1	8402	1	UBR4	1	19477120	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7139623	19477120	229773501	7	4581										
LDLRAD2	401944	broad.mit.edu	37	chr1	22141309	22141309	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtgggcgaagtcacctctttCcgtctgggtgagctggggct	16	10	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:22141309C>T	uc001bfg.1	+	2	691	c.504C>T	c.(502-504)TTC>TTT	p.F168F		NM_001013693	NP_001013715	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain	168	Extracellular (Potential).					integral to membrane	receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		TCACCTCTTTCCGTCTGGGTG	0.711													0	0	0	1	0	8	9										T	22141309	C	T	22141309	2	4	18	1	0	0	0	0	0	0	0	1	8706	854	30	1		1	LDLRAD2	1	22141309	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2664189	22141309	227109312	8	4582										
C1orf213	148898	broad.mit.edu	37	chr1	23695890	23695890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caaaagatccactagatcgtCgtctccaaaacctgagagac	7	12	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:23695890C>T	uc001bgw.2	+	1	427	c.100C>T	c.(100-102)CGT>TGT	p.R34C	ZNF436_uc001bgt.2_5'Flank|ZNF436_uc001bgu.2_5'UTR|C1orf213_uc001bgv.2_Missense_Mutation_p.R34C	NM_138479	NP_612488			hypothetical protein LOC148898 isoform 1												0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.97e-26)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;5.23e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		ACTAGATCGTCGTCTCCAAAA	0.572													0	0	0	1	0	34	47										T	23695890	C	T	23695890	3	4	18	1	0	0	0	0	1	0	0	0	2030	884	31	1	102	1	C1orf213	1	23695890	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1554581	23695890	225554731	9	4583										
ARID1A	8289	broad.mit.edu	37	chr1	27106492	27106492	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cactaacttatgaaaaggagGaggaacaggaccaaggggtg	14	6	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:27106492G>T	uc001bmv.1	+	20	6476	c.6103G>T	c.(6103-6105)GAG>TAG	p.E2035*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.E1818*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.E881*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.E363*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.E277*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2035					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGAAAAGGAGGAGGAACAGGA	0.557			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								1	0	2.47907e-22	1	2.60217e-22	54	100										T	27106492	G	T	27106492	4	4	18	1	0	0	0	0	0	1	0	0	913	1175	41	3	6181	3	ARID1A	1	27106492	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3410602	27106492	222144129	10	4584										
SFN	2810	broad.mit.edu	37	chr1	27189727	27189727	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagagagccagtctgatccaGaaggccaagctggcagagca	14	10	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:27189727G>A	uc001bnc.1	+	1	95	c.24G>A	c.(22-24)CAG>CAA	p.Q8Q		NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	8					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		GTCTGATCCAGAAGGCCAAGC	0.627													0	0	0	1	0	76	85										A	27189727	G	A	27189727	2	1	18	1	0	0	0	0	0	0	0	1	14159	933	33	1		1	SFN	1	27189727	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	83235	27189727	222060894	11	4585										
SDC3	9672	broad.mit.edu	37	chr1	31347175	31347175	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccttccgctccaggatactCttctgaggcagctgagcagc	10	14	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:31347175C>T	uc001bse.2	-	4	1178	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	SDC3_uc001bsd.2_Silent_p.K319K	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	377	Extracellular (Potential).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGATACTCTTCTGAGGCA	0.652													0	0	0	1	0	38	46										T	31347175	C	T	31347175	2	4	18	1	0	0	0	0	0	0	0	1	13953	912	32	1		1	SDC3	1	31347175	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4157448	31347175	217903446	12	4586										
TMEM54	113452	broad.mit.edu	37	chr1	33363913	33363913	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttccggaagtcgcccacactCaggcctcctgtgggggacag	13	14	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:33363913C>G	uc001bwi.1	-	2	138	c.24G>C	c.(22-24)CTG>CTC	p.L8L	TMEM54_uc001bwj.1_Silent_p.L8L|TMEM54_uc001bwk.1_Silent_p.L8L	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	8						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CGCCCACACTCAGGCCTCCTG	0.617													0	0	0	1	0	44	55										G	33363913	C	G	33363913	2	3	18	1	0	0	0	0	0	0	0	1	16177	813	29	1		1	TMEM54	1	33363913	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2016738	33363913	215886708	13	4587										
CSMD2	114784	broad.mit.edu	37	chr1	33987087	33987087	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctttgaaagccgaactgccCaaagccttggcccttgacag	9	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:33987087C>G	uc001bxn.1	-	67	10170	c.10141G>C	c.(10141-10143)GGG>CGG	p.G3381R	CSMD2_uc001bxm.1_Missense_Mutation_p.G3525R	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3381	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCGAACTGCCCAAAGCCTTGG	0.602													0	0	0	1	0	37	69										G	33987087	C	G	33987087	3	3	18	1	0	0	0	0	1	0	0	0	3945	594	21	4	334	4	CSMD2	1	33987087	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	623174	33987087	215263534	14	4588										
ZMYM6	9204	broad.mit.edu	37	chr1	35485180	35485180	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agatgatgcaaaagaaagctGaaagcctgggttcaactgct	11	7	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:35485180G>A	uc001byh.2	-	4	430	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	ZMYM6_uc001byf.1_Nonsense_Mutation_p.Q68*|ZMYM6_uc010oht.1_5'UTR|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Nonsense_Mutation_p.Q68*|ZMYM6_uc009vur.1_Intron|ZMYM6_uc001byj.2_Nonsense_Mutation_p.Q68*|ZMYM6_uc001byi.2_Nonsense_Mutation_p.Q68*|ZMYM6_uc001byk.2_Nonsense_Mutation_p.Q68*	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	68					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				AAAGAAAGCTGAAAGCCTGGG	0.368													0	0	0	1	0	22	39										A	35485180	G	A	35485180	4	1	18	1	0	0	0	0	0	1	0	0	17701	1299	45	1	3827	1	ZMYM6	1	35485180	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1498093	35485180	213765441	15	4589										
CLSPN	63967	broad.mit.edu	37	chr1	36211080	36211080	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggaaaagagcctgagcaaaGagcaagtgcttcttccattg	12	8	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:36211080G>C	uc001bzi.2	-	16	3018	c.2938C>G	c.(2938-2940)CTT>GTT	p.L980V	CLSPN_uc009vux.2_Missense_Mutation_p.L916V	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	980	CKB motif 3.				activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCTGAGCAAAGAGCAAGTGCT	0.438													0	0	0	1	0	30	42										C	36211080	G	C	36211080	3	2	18	1	0	0	0	0	1	0	0	0	3560	942	33	1	1121	1	CLSPN	1	36211080	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	725900	36211080	213039541	16	4590										
MANEAL	149175	broad.mit.edu	37	chr1	38265658	38265658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caatggcaagtactatgagaCggccctgcaggcggccctga	13	12	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:38265658C>T	uc001cby.2	+	4	1238	c.1157C>T	c.(1156-1158)ACG>ATG	p.T386M	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.T164M	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	386	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TACTATGAGACGGCCCTGCAG	0.567													0	0	0	1	0	47	60										T	38265658	C	T	38265658	3	4	18	1	0	0	0	0	1	0	0	0	9222	536	19	2	1171	2	MANEAL	1	38265658	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2054578	38265658	210984963	17	4591										
TESK2	10420	broad.mit.edu	37	chr1	45811074	45811074	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	catctcgtggccggtagtatGggtccaagacactcactgta	11	11	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:45811074G>C	uc001cns.1	-	11	1557	c.1154C>G	c.(1153-1155)CCA>CGA	p.P385R	TESK2_uc009vxr.1_Missense_Mutation_p.P356R|TESK2_uc010olo.1_Missense_Mutation_p.P302R|TESK2_uc009vxs.1_Missense_Mutation_p.P177R	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	385					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					CCGGTAGTATGGGTCCAAGAC	0.557													0	0	0	1	0	55	48										C	45811074	G	C	45811074	3	2	18	1	0	0	0	0	1	0	0	0	15765	1348	47	4	565	4	TESK2	1	45811074	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7545416	45811074	203439547	18	4592										
IPP	3652	broad.mit.edu	37	chr1	46212053	46212053	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atctgatgaaaaaggactatCagcagccttgggacagtcct	10	9	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:46212053C>T	uc001cou.2	-	2	298	c.31G>A	c.(31-33)GAT>AAT	p.D11N	IPP_uc001cos.3_Missense_Mutation_p.D11N	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	11						actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AAAGGACTATCAGCAGCCTTG	0.408													0	0	0	1	0	48	118										T	46212053	C	T	46212053	3	4	18	1	0	0	0	0	1	0	0	0	7800	826	29	1	1857	1	IPP	1	46212053	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	400979	46212053	203038568	19	4593										
LRRC41	10489	broad.mit.edu	37	chr1	46751935	46751935	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aacagcaggtggcggaacttGagagtgtgcagggagctggc	18	7	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:46751935G>C	uc001cpn.2	-	4	638	c.594C>G	c.(592-594)CTC>CTG	p.L198L	LRRC41_uc010omb.1_Silent_p.L198L|LRRC41_uc001cpo.1_Silent_p.L198L	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	198										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GGCGGAACTTGAGAGTGTGCA	0.592													0	0	0	1	0	40	45										C	46751935	G	C	46751935	2	2	18	1	0	0	0	0	0	0	0	1	8999	1277	45	1		1	LRRC41	1	46751935	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	539882	46751935	202498686	20	4594										
HOOK1	51361	broad.mit.edu	37	chr1	60297859	60297859	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtaatgtaaagaaggtccttCaaggaattatgagttattat	9	3	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:60297859C>T	uc009wad.2	+	5	349	c.247C>T	c.(247-249)CAA>TAA	p.Q83*	HOOK1_uc001czo.2_Nonsense_Mutation_p.Q83*|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Nonsense_Mutation_p.Q41*	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	83	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					GAAGGTCCTTCAAGGAATTAT	0.289													0	0	0	1	0	56	85										T	60297859	C	T	60297859	4	4	18	1	0	0	0	0	0	1	0	0	7282	827	29	1	261	1	HOOK1	1	60297859	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	13545924	60297859	188952762	21	4595										
IFI44L	10964	broad.mit.edu	37	chr1	79093672	79093672	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgcttggaaatgtttctttGagtcttctctataagtctag	8	7	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:79093672G>C	uc010oro.1	+	2	251	c.72G>C	c.(70-72)TTG>TTC	p.L24F	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	24						cytoplasm					0						ATGTTTCTTTGAGTCTTCTCT	0.363													0	0	0	1	0	32	24										C	79093672	G	C	79093672	3	2	18	1	0	0	0	0	1	0	0	0	7518	1281	45	1	74	1	IFI44L	1	79093672	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	18795813	79093672	170156949	22	4596										
SEP15	9403	broad.mit.edu	37	chr1	87379771	87379771	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gccggcaccagacacccactCggcccagccgccatcgctac	9	21	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:87379771C>G	uc010osi.1	-	1	337	c.24G>C	c.(22-24)CCG>CCC	p.P8P	HS2ST1_uc001dmc.3_5'Flank|HS2ST1_uc010osk.1_5'Flank|SEP15_uc010osj.1_Silent_p.P8P	NM_004261	NP_004252	O60613	SEP15_HUMAN	15 kDa selenoprotein isoform 1 precursor	5					'de novo' posttranslational protein folding	endoplasmic reticulum lumen	selenium binding				0		Lung NSC(277;0.153)		all cancers(265;0.00744)|Epithelial(280;0.0333)		GACACCCACTCGGCCCAGCCG	0.587													0	0	0	1	0	53	74										G	87379771	C	G	87379771	2	3	18	1	0	0	0	0	0	0	0	1	14053	871	31	1		1	SEP15	1	87379771	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	8286099	87379771	161870850	23	4597										
LRRC8C	84230	broad.mit.edu	37	chr1	90179371	90179371	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaatggactcctgataaactGaggcagaagctacagacaaa	10	8	0	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:90179371G>A	uc001dnl.3	+	3	1484	c.1242G>A	c.(1240-1242)CTG>CTA	p.L414L		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	414	LRR 1.					endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CTGATAAACTGAGGCAGAAGC	0.413													0	0	0	1	0	41	53										A	90179371	G	A	90179371	2	1	18	1	0	0	0	0	0	0	0	1	9023	1277	45	1		1	LRRC8C	1	90179371	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2799600	90179371	159071250	24	4598										
SNX7	51375	broad.mit.edu	37	chr1	99150470	99150470	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgatggacatgaactccttCagccctatgatgccaacatc	7	12	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:99150470C>G	uc010ouc.1	+	2	262	c.210C>G	c.(208-210)TTC>TTG	p.F70L	SNX7_uc001dsa.2_Missense_Mutation_p.F6L|SNX7_uc010oud.1_Missense_Mutation_p.F70L	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	6					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		TGAACTCCTTCAGCCCTATGA	0.338													0	0	0	1	0	50	85										G	99150470	C	G	99150470	3	3	18	1	0	0	0	0	1	0	0	0	14907	825	29	1	216	1	SNX7	1	99150470	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	8971099	99150470	150100151	25	4599										
FAM40A	85369	broad.mit.edu	37	chr1	110591786	110591786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggatgtaaaccgccacaaaGaggtcattgttaaggccatt	10	8	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:110591786G>C	uc001dza.1	+	16	1733	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	FAM40A_uc001dyz.1_Missense_Mutation_p.E477Q|FAM40A_uc009wfp.1_Missense_Mutation_p.E396Q	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	572						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		CCGCCACAAAGAGGTCATTGT	0.522													0	0	0	1	0	30	50										C	110591786	G	C	110591786	3	2	18	1	0	0	0	0	1	0	0	0	5560	943	33	1	1776	1	FAM40A	1	110591786	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11441316	110591786	138658835	26	4600										
FAM40A	85369	broad.mit.edu	37	chr1	110592108	110592108	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tacatggcccagcacctggtGtttgccaactgcattccttt	8	13	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:110592108G>A	uc001dza.1	+	17	1834	c.1815G>A	c.(1813-1815)GTG>GTA	p.V605V	FAM40A_uc001dyz.1_Silent_p.V510V|FAM40A_uc009wfp.1_Silent_p.V429V	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	605						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		AGCACCTGGTGTTTGCCAACT	0.473													0	0	0	1	0	57	72										A	110592108	G	A	110592108	2	1	18	1	0	0	0	0	0	0	0	1	5560	1364	48	2		2	FAM40A	1	110592108	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	322	110592108	138658513	27	4601										
PPM1J	333926	broad.mit.edu	37	chr1	113253221	113253221	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtgctcatattgtgtcaggtCatacactcgtacctggtggg	12	9	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:113253221C>G	uc001ect.1	-	9	1258	c.1231G>C	c.(1231-1233)GAC>CAC	p.D411H	PPM1J_uc009wgl.1_RNA|PPM1J_uc001ecs.1_Missense_Mutation_p.D205H	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	411	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTGTCAGGTCATACACTCGT	0.532													0	0	0	1	0	90	125										G	113253221	C	G	113253221	3	3	18	1	0	0	0	0	1	0	0	0	12342	826	29	1	294	1	PPM1J	1	113253221	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2661113	113253221	135997400	28	4602										
OLFML3	56944	broad.mit.edu	37	chr1	114523069	114523069	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaaggagcgggaggcactcaGaactgaggccgacaccatct	14	11	2	2	rs144544470	by1000genomes	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:114523069G>C	uc001eer.1	+	2	339	c.230G>C	c.(229-231)AGA>ACA	p.R77T	OLFML3_uc001ees.1_Missense_Mutation_p.R57T|OLFML3_uc001eet.1_5'UTR	NM_020190	NP_064575	Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3 precursor	77	Potential.				multicellular organismal development	extracellular region					0	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGCACTCAGAACTGAGGCC	0.587													0	0	0	1	0	40	71										C	114523069	G	C	114523069	3	2	18	1	0	0	0	0	1	0	0	0	10859	942	33	1	236	1	OLFML3	1	114523069	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1269848	114523069	134727552	29	4603										
TRIM45	80263	broad.mit.edu	37	chr1	117656050	117656050	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggagcagaaggtgcagcagtGaaacacgcctgagtgtgggc	17	8	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:117656050G>A	uc001egz.2	-	5	2113	c.1525C>T	c.(1525-1527)CAC>TAC	p.H509Y	TRIM45_uc009whe.2_Missense_Mutation_p.H491Y|TRIM45_uc001eha.2_Missense_Mutation_p.H405Y	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	509						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		GTGCAGCAGTGAAACACGCCT	0.572													0	0	0	1	0	48	39										A	117656050	G	A	117656050	3	1	18	1	0	0	0	0	1	0	0	0	16517	1290	45	1	225	1	TRIM45	1	117656050	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3132981	117656050	131594571	30	4604										
FAM72D	728833	broad.mit.edu	37	chr1	143912363	143912363	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtaatgctcctactattttGattcccctaggctaaaattc	5	10	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:143912363G>C	uc002qvn.1	-	1	781	c.-67C>G	c.(-69--65)ATCAA>ATGAA		FAM72D_uc010evy.1_Translation_Start_Site	NM_207418	NP_997301	Q6L9T8	FA72D_HUMAN	hypothetical protein LOC653573												0						CTACTATTTTGATTCCCCTAG	0.418													0	0	0	1	0	41	80										C	143912363	G	C	143912363	1	2	18	1	0	0	0	0	0	0	0	0	5616	1305	45	1		1	FAM72D	1	143912363	Translation_Start_Site	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	26256313	143912363	105338258	31	4605										
PDE4DIP	9659	broad.mit.edu	37	chr1	144882814	144882814	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcctcgatctcccatccatCagacattgcttctcccatct	3	17	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:144882814C>T	uc001elw.3	-	24	3496	c.3205G>A	c.(3205-3207)GAT>AAT	p.D1069N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.D1135N|PDE4DIP_uc001elv.3_Missense_Mutation_p.D76N	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1069					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCCATCCATCAGACATTGCT	0.512			T	PDGFRB	MPD								0	0	0	1	0	116	494										T	144882814	C	T	144882814	3	4	18	1	0	0	0	0	1	0	0	0	11643	826	29	1	3919	1	PDE4DIP	1	144882814	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	970451	144882814	104367807	32	4606										
PDE4DIP	9659	broad.mit.edu	37	chr1	145075664	145075664	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggccgccgcagctgcttcttCctcctcggccgctgctgccc	11	20	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145075664C>A	uc001emh.2	-	1	416	c.199G>T	c.(199-201)GAA>TAA	p.E67*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Nonsense_Mutation_p.E67*|PDE4DIP_uc001emk.2_Nonsense_Mutation_p.E67*	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTGCTTCTTCCTCCTCGGCC	0.721			T	PDGFRB	MPD								1	0	6.05902e-23	1	6.3708e-23	25	208										A	145075664	C	A	145075664	4	1	18	1	0	0	0	0	0	1	0	0	11643	864	30	3	8613	3	PDE4DIP	1	145075664	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	192850	145075664	104174957	33	4607										
NOTCH2NL	388677	broad.mit.edu	37	chr1	145281491	145281491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcttcacagggcagaagtgtGagactgatgtcaatgagtgt	14	6	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145281491G>A	uc001emn.3	+	4	791	c.421G>A	c.(421-423)GAG>AAG	p.E141K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.E141K|NOTCH2NL_uc001emo.2_Missense_Mutation_p.E141K|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	141	EGF-like 4.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GCAGAAGTGTGAGACTGATGT	0.552													0	0	0	1	0	64	553										A	145281491	G	A	145281491	3	1	18	1	0	0	0	0	1	0	0	0	10549	1291	45	1	431	1	NOTCH2NL	1	145281491	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	205827	145281491	103969130	34	4608										
TXNIP	10628	broad.mit.edu	37	chr1	145439874	145439874	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagccaactcaagagacaaaGaaaaactttgaagtagtgga	9	7	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145439874G>C	uc001enn.3	+	3	761	c.420G>C	c.(418-420)AAG>AAC	p.K140N	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.K85N	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	140					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAGAGACAAAGAAAAACTTTG	0.438													0	0	0	1	0	62	68										C	145439874	G	C	145439874	3	2	18	1	0	0	0	0	1	0	0	0	16800	933	33	1	430	1	TXNIP	1	145439874	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	158383	145439874	103810747	35	4609										
TXNIP	10628	broad.mit.edu	37	chr1	145440123	145440123	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgtctctgctcgaattgacaGaaaaggattctgtgaaggta	11	6	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:145440123G>A	uc001enn.3	+	4	898	c.557G>A	c.(556-558)AGA>AAA	p.R186K	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.R131K	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	186					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CGAATTGACAGAAAAGGATTC	0.458													0	0	0	1	0	101	142										A	145440123	G	A	145440123	3	1	18	1	0	0	0	0	1	0	0	0	16800	942	33	1	571	1	TXNIP	1	145440123	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	249	145440123	103810498	36	4610										
ADAMTSL4	54507	broad.mit.edu	37	chr1	150532597	150532597	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtacaggcccggctctgcgtCtacccctactacacagccac	8	18	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:150532597C>T	uc001eux.2	+	19	3386	c.3150C>T	c.(3148-3150)GTC>GTT	p.V1050V	ADAMTSL4_uc009wlw.2_Silent_p.V1073V|ADAMTSL4_uc010pcg.1_Silent_p.V1011V|ADAMTSL4_uc009wlx.2_Silent_p.V213V	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	1050	PLAC.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GGCTCTGCGTCTACCCCTACT	0.622											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	89	131										T	150532597	C	T	150532597	2	4	18	1	0	0	0	0	0	0	0	1	277	900	32	1		1	ADAMTSL4	1	150532597	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5092474	150532597	98718024	37	4611										
SEMA6C	10500	broad.mit.edu	37	chr1	151111130	151111130	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tagctgcggcacacagggctGaatgagttcgttccacaggc	13	11	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:151111130G>C	uc001ewu.2	-	7	732	c.432C>G	c.(430-432)TTC>TTG	p.F144L	SEMA6C_uc001ewv.2_Missense_Mutation_p.F144L|SEMA6C_uc001eww.2_Missense_Mutation_p.F144L|SEMA6C_uc010pcq.1_Missense_Mutation_p.F144L|SEMA6C_uc009wml.1_RNA	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	144	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACACAGGGCTGAATGAGTTCG	0.527													0	0	0	1	0	36	53										C	151111130	G	C	151111130	3	2	18	1	0	0	0	0	1	0	0	0	14041	1281	45	1	2512	1	SEMA6C	1	151111130	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	578533	151111130	98139491	38	4612										
RFX5	5993	broad.mit.edu	37	chr1	151316209	151316209	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgtgcagatcgggcagagatGagatgctgctgtagcaggaa	16	6	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:151316209G>A	uc001exv.1	-	9	919	c.705C>T	c.(703-705)CTC>CTT	p.L235L	RFX5_uc001exw.1_Silent_p.L235L|RFX5_uc009wmr.1_Silent_p.L235L|RFX5_uc010pcx.1_Silent_p.L195L	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	235						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGGCAGAGATGAGATGCTGCT	0.582													0	0	0	1	0	40	66										A	151316209	G	A	151316209	2	1	18	1	0	0	0	0	0	0	0	1	13266	1277	45	1		1	RFX5	1	151316209	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	205079	151316209	97934412	39	4613										
ASH1L	55870	broad.mit.edu	37	chr1	155365333	155365333	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctttctttaattggatcaatCgactctttgggctgtgataa	8	7	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:155365333C>T	uc009wqq.2	-	7	6500	c.6020G>A	c.(6019-6021)CGA>CAA	p.R2007Q	ASH1L_uc001fkt.2_Missense_Mutation_p.R2007Q	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2007					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTGGATCAATCGACTCTTTGG	0.413													0	0	0	1	0	28	42										T	155365333	C	T	155365333	3	4	18	1	0	0	0	0	1	0	0	0	1041	884	31	1	2962	1	ASH1L	1	155365333	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4049124	155365333	93885288	40	4614										
LMNA	4000	broad.mit.edu	37	chr1	156100507	156100507	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gccgcactgagcactgctctCagtgagaagcgcacgctgga	13	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:156100507C>G	uc001fni.2	+	2	705	c.456C>G	c.(454-456)CTC>CTG	p.L152L	LMNA_uc001fnf.1_Silent_p.L152L|LMNA_uc001fng.2_Silent_p.L152L|LMNA_uc001fnh.2_Silent_p.L152L|LMNA_uc009wro.1_Silent_p.L152L|LMNA_uc010pgz.1_Silent_p.L40L|LMNA_uc001fnj.2_Silent_p.L71L|LMNA_uc001fnk.2_Silent_p.L53L	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	152	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					GCACTGCTCTCAGTGAGAAGC	0.637									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome		OREG0013866	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	14	19										G	156100507	C	G	156100507	2	3	18	1	0	0	0	0	0	0	0	1	8848	813	29	1		1	LMNA	1	156100507	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	735174	156100507	93150114	41	4615										
SMG5	23381	broad.mit.edu	37	chr1	156230322	156230322	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcggagcgggggcaggttacGaagagccatgtcctctggga	17	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:156230322G>A	uc001foc.3	-	15	2352	c.2203C>T	c.(2203-2205)CGT>TGT	p.R735C	SMG5_uc009wrv.2_Missense_Mutation_p.R220C	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	735					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GGCAGGTTACGAAGAGCCATG	0.562													0	0	0	1	0	46	63										A	156230322	G	A	156230322	3	1	18	1	0	0	0	0	1	0	0	0	14796	1058	37	1	879	1	SMG5	1	156230322	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	129815	156230322	93020299	42	4616										
NES	10763	broad.mit.edu	37	chr1	156639156	156639156	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gactctctatctccttccctCtgagtgaacttcaggaactg	7	13	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:156639156C>G	uc001fpq.2	-	4	4957	c.4824G>C	c.(4822-4824)CAG>CAC	p.Q1608H		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1608	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCCTTCCCTCTGAGTGAACT	0.617													0	0	0	1	0	33	59										G	156639156	C	G	156639156	3	3	18	1	0	0	0	0	1	0	0	0	10337	912	32	1	45	1	NES	1	156639156	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	408834	156639156	92611465	43	4617										
FCRL3	115352	broad.mit.edu	37	chr1	157665209	157665209	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccagaatgttctgcagtcaGagagaggttgaaggaggctc	14	7	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:157665209G>A	uc001frb.2	-	8	1613	c.1321C>T	c.(1321-1323)CTG>TTG	p.L441L	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.L441L|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.L167L|FCRL3_uc001frc.1_Silent_p.L441L	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	441	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TCTGCAGTCAGAGAGAGGTTG	0.557													0	0	0	1	0	90	131										A	157665209	G	A	157665209	2	1	18	1	0	0	0	0	0	0	0	1	5796	933	33	1		1	FCRL3	1	157665209	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1026053	157665209	91585412	44	4618										
CADM3	57863	broad.mit.edu	37	chr1	159169587	159169587	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcacctaccacgccatcatCggtgggatcgtggctttcat	10	13	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:159169587C>T	uc001ftl.2	+	8	1141	c.999C>T	c.(997-999)ATC>ATT	p.I333I	CADM3_uc001ftk.2_Silent_p.I367I|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	333	Helical; (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					ACGCCATCATCGGTGGGATCG	0.542													0	0	0	1	0	73	75										T	159169587	C	T	159169587	2	4	18	1	0	0	0	0	0	0	0	1	2568	874	31	1		1	CADM3	1	159169587	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1504378	159169587	90081034	45	4619										
COPA	1314	broad.mit.edu	37	chr1	160262955	160262955	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggaaaagccaaggttacttaCccgcatggctgtttcgaaag	11	9	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:160262955C>T	uc009wti.2	-	27	3217	c.2823_splice	c.e27+1	p.R941_splice	COPA_uc001fvv.3_Splice_Site_p.R950_splice	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform						COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGTTACTTACCCGCATGGCT	0.468													0	0	0	1	0	51	226										T	160262955	C	T	160262955	5	4	18	1	0	0	0	0	0	0	1	0	3727	521	18	2	878	2	COPA	1	160262955	Splice_Site	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1093368	160262955	88987666	46	4620										
CD48	962	broad.mit.edu	37	chr1	160681499	160681499	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctggtcaccaggagtgacaGaggcagcagtagcaattcca	13	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:160681499G>A	uc001fwn.2	-	1	87	c.55C>T	c.(55-57)CTG>TTG	p.L19L	CD48_uc001fwo.1_Silent_p.L19L|CD48_uc001fwp.2_Silent_p.L19L	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	19					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AGGAGTGACAGAGGCAGCAGT	0.532													0	0	0	1	0	34	57										A	160681499	G	A	160681499	2	1	18	1	0	0	0	0	0	0	0	1	3020	933	33	1		1	CD48	1	160681499	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	418544	160681499	88569122	47	4621										
GPA33	10223	broad.mit.edu	37	chr1	167038281	167038281	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caatggtgatggaggcatcgGactgctcagcattgttggat	14	7	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:167038281G>C	uc001gea.1	-	3	637	c.293C>G	c.(292-294)TCC>TGC	p.S98C		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	98	Ig-like V-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						GGAGGCATCGGACTGCTCAGC	0.502													0	0	0	1	0	34	46										C	167038281	G	C	167038281	3	2	18	1	0	0	0	0	1	0	0	0	6586	1174	41	1	686	1	GPA33	1	167038281	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6356782	167038281	82212340	48	4622										
CD247	919	broad.mit.edu	37	chr1	167408587	167408587	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgaggctgacttacgttataGagctggttctggccctgctg	13	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:167408587G>C	uc001gei.3	-	3	358	c.213C>G	c.(211-213)CTC>CTG	p.L71L	CD247_uc001gej.3_Silent_p.L71L|CD247_uc001gek.2_Silent_p.L71L	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	71	Cytoplasmic (Potential).|ITAM 1.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TTACGTTATAGAGCTGGTTCT	0.572													0	0	0	1	0	53	103										C	167408587	G	C	167408587	2	2	18	1	0	0	0	0	0	0	0	1	2988	929	33	1		1	CD247	1	167408587	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	370306	167408587	81842034	49	4623										
GPR161	23432	broad.mit.edu	37	chr1	168056841	168056841	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acctttgatttgttccacttCatcctcaaatgtcaccgagc	5	13	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:168056841C>A	uc001gfc.2	-	7	1620	c.1306G>T	c.(1306-1308)GAA>TAA	p.E436*	GPR161_uc001gfb.2_Nonsense_Mutation_p.E304*|GPR161_uc010pll.1_Nonsense_Mutation_p.E346*|GPR161_uc010plm.1_Nonsense_Mutation_p.E322*|GPR161_uc009wvo.2_Nonsense_Mutation_p.E453*|GPR161_uc001gfd.2_Nonsense_Mutation_p.E436*|GPR161_uc010pln.1_Nonsense_Mutation_p.E456*	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	436	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					TGTTCCACTTCATCCTCAAAT	0.483													1	0	1.15365e-47	1	1.23418e-47	95	143										A	168056841	C	A	168056841	4	1	18	1	0	0	0	0	0	1	0	0	6665	835	29	3	291	3	GPR161	1	168056841	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	648254	168056841	81193780	50	4624										
TIPRL	261726	broad.mit.edu	37	chr1	168165852	168165852	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aattgatggggtgcttatcaGaatgaatgacacgagacttt	11	5	1	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:168165852G>C	uc001gfg.2	+	5	729	c.584G>C	c.(583-585)AGA>ACA	p.R195T	TIPRL_uc001gfh.2_Missense_Mutation_p.R195T	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	195	Interaction with PPP2CA.				DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					GTGCTTATCAGAATGAATGAC	0.328													0	0	0	1	0	65	90										C	168165852	G	C	168165852	3	2	18	1	0	0	0	0	1	0	0	0	15923	942	33	1	627	1	TIPRL	1	168165852	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	109011	168165852	81084769	51	4625										
NME7	29922	broad.mit.edu	37	chr1	169292506	169292506	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccgctttaaaaaggtgcgatGattctttacatcatgctaga	8	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:169292506G>A	uc001gfu.2	-	3	365	c.127C>T	c.(127-129)CAT>TAT	p.H43Y	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.H7Y|NME7_uc001gfv.1_Missense_Mutation_p.H43Y	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	43	DM10.				CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					AAGGTGCGATGATTCTTTACA	0.308													0	0	0	1	0	68	106										A	169292506	G	A	169292506	3	1	18	1	0	0	0	0	1	0	0	0	10496	1290	45	1	1043	1	NME7	1	169292506	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1126654	169292506	79958115	52	4626										
SMG7	9887	broad.mit.edu	37	chr1	183518360	183518360	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagaaatccttattggagaaGccctcagagctcatgtcaca	8	10	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:183518360G>T	uc001gqg.2	+	18	2882	c.2760G>T	c.(2758-2760)AAG>AAT	p.K920N	SMG7_uc001gqf.2_Missense_Mutation_p.K924N|SMG7_uc001gqh.2_Missense_Mutation_p.K874N|SMG7_uc001gqi.2_Missense_Mutation_p.K832N|SMG7_uc010poc.1_Missense_Mutation_p.K928N	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	920					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TATTGGAGAAGCCCTCAGAGC	0.388													1	0	9.72345e-25	1	1.02414e-24	41	42										T	183518360	G	T	183518360	3	4	18	1	0	0	0	0	1	0	0	0	14798	962	34	4	2984	4	SMG7	1	183518360	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	14225854	183518360	65732261	53	4627										
SMG7	9887	broad.mit.edu	37	chr1	183520021	183520021	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gactccagataacagggataGaaggactgcagatcggtgga	14	7	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:183520021G>A	uc001gqg.2	+	20	3241	c.3119G>A	c.(3118-3120)AGA>AAA	p.R1040K	SMG7_uc001gqf.2_Missense_Mutation_p.R1044K|SMG7_uc001gqh.2_Missense_Mutation_p.R994K|SMG7_uc001gqi.2_Missense_Mutation_p.R952K|SMG7_uc010poc.1_Missense_Mutation_p.R1048K	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	1040					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AACAGGGATAGAAGGACTGCA	0.458													0	0	0	1	0	63	62										A	183520021	G	A	183520021	3	1	18	1	0	0	0	0	1	0	0	0	14798	942	33	1	3351	1	SMG7	1	183520021	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1661	183520021	65730600	54	4628										
GLT25D2	23127	broad.mit.edu	37	chr1	183920230	183920230	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcctgtcctttctgcgtttGaggtttatcatgaaaatcta	8	9	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:183920230G>C	uc001gqr.2	-	8	1419	c.1047C>G	c.(1045-1047)CTC>CTG	p.L349L	GLT25D2_uc010poj.1_Silent_p.L349L|GLT25D2_uc001gqq.2_Silent_p.L86L|GLT25D2_uc001gqs.2_Silent_p.L229L	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	349					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						TTCTGCGTTTGAGGTTTATCA	0.413													0	0	0	1	0	127	202										C	183920230	G	C	183920230	2	2	18	1	0	0	0	0	0	0	0	1	6467	1277	45	1		1	GLT25D2	1	183920230	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	400209	183920230	65330391	55	4629										
NEK7	140609	broad.mit.edu	37	chr1	198262135	198262135	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaatggatacaacttcaaatCtgacatctggtctcttggct	7	9	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:198262135C>T	uc001gun.3	+	8	977	c.650C>T	c.(649-651)TCT>TTT	p.S217F		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	217	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						AACTTCAAATCTGACATCTGG	0.323													0	0	0	1	0	133	170										T	198262135	C	T	198262135	3	4	18	1	0	0	0	0	1	0	0	0	10329	913	32	1	676	1	NEK7	1	198262135	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	14341905	198262135	50988486	56	4630										
OPTC	26254	broad.mit.edu	37	chr1	203467966	203467966	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gccgaagacttcaaagggctGagtatgtaatgccctgggaa	13	8	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:203467966G>C	uc001gzu.1	+	4	644	c.528G>C	c.(526-528)CTG>CTC	p.L176L		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	176						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			TCAAAGGGCTGAGTATGTAAT	0.557													0	0	0	1	0	45	55										C	203467966	G	C	203467966	2	2	18	1	0	0	0	0	0	0	0	1	10888	1304	45	1		1	OPTC	1	203467966	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	5205831	203467966	45782655	57	4631										
IKBKE	9641	broad.mit.edu	37	chr1	206649607	206649607	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcatgcgcctcgtaggggagGaggggcagagcatctacaag	16	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:206649607G>T	uc001hdz.1	+	6	810	c.442G>T	c.(442-444)GAG>TAG	p.E148*	IKBKE_uc009xbu.1_Nonsense_Mutation_p.E148*|IKBKE_uc009xbv.1_Nonsense_Mutation_p.E148*|IKBKE_uc001hea.1_Nonsense_Mutation_p.E63*	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	148	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CGTAGGGGAGGAGGGGCAGAG	0.607													1	0	5.5144e-22	1	5.76848e-22	59	81										T	206649607	G	T	206649607	4	4	18	1	0	0	0	0	0	1	0	0	7612	1175	41	3	456	3	IKBKE	1	206649607	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3181641	206649607	42601014	58	4632										
OBSCN	84033	broad.mit.edu	37	chr1	228467882	228467882	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccggtgtgtctcttgcagcgCgggaggtgacagtgacaggg	18	9	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:228467882C>T	uc009xez.1	+	29	7710	c.7666C>T	c.(7666-7668)CGG>TGG	p.R2556W	OBSCN_uc001hsn.2_Missense_Mutation_p.R2556W|OBSCN_uc001hsp.1_Missense_Mutation_p.R255W|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2556	Ig-like 24.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCTTGCAGCGCGGGAGGTGAC	0.642													0	0	0	1	0	55	73										T	228467882	C	T	228467882	3	4	18	1	0	0	0	0	1	0	0	0	10812	759	27	2	7776	2	OBSCN	1	228467882	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	21818275	228467882	20782739	59	4633										
LYST	1130	broad.mit.edu	37	chr1	235929543	235929543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caaatgatctacaaacctctCggggcatgggtgtgagttgc	12	9	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:235929543C>T	uc001hxj.2	-	21	6132	c.5957G>A	c.(5956-5958)CGA>CAA	p.R1986Q	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1986					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACAAACCTCTCGGGGCATGGG	0.328									Chediak-Higashi_syndrome				0	0	0	1	0	121	123										T	235929543	C	T	235929543	3	4	18	1	0	0	0	0	1	0	0	0	9128	884	31	1	5580	1	LYST	1	235929543	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7461661	235929543	13321078	60	4634										
OR2L3	391192	broad.mit.edu	37	chr1	248224664	248224664	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctccttgctgtctaccacatGaaatctgcagaagggaggaa	10	10	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:248224664G>A	uc001idx.1	+	1	681	c.681G>A	c.(679-681)ATG>ATA	p.M227I	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCTACCACATGAAATCTGCAG	0.468													0	0	0	1	0	92	158										A	248224664	G	A	248224664	3	1	18	1	0	0	0	0	1	0	0	0	11008	1290	45	1	683	1	OR2L3	1	248224664	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	12295121	248224664	1025957	61	4635										
OR2M5	127059	broad.mit.edu	37	chr1	248309371	248309371	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcaggaaagtgttaggaaagGgcaagtgtggagagtgagta	17	2	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr1:248309371G>T	uc010pze.1	+	1	922	c.922G>T	c.(922-924)GGC>TGC	p.G308C		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GTTAGGAAAGGGCAAGTGTGG	0.433													1	0	2.44723e-14	1	2.52127e-14	27	43										T	248309371	G	T	248309371	3	4	18	1	0	0	0	0	1	0	0	0	11013	1232	43	4	924	4	OR2M5	1	248309371	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	84707	248309371	941250	62	4636										
CPSF3	51692	broad.mit.edu	37	chr2	9583767	9583767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcaaaccagtgaatttattCgtgctttgaaaccgcctcat	7	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:9583767C>T	uc002qzo.1	+	10	1254	c.1219C>T	c.(1219-1221)CGT>TGT	p.R407C	CPSF3_uc010ewx.1_Intron|CPSF3_uc002qzp.1_Missense_Mutation_p.R370C	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	407					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TGAATTTATTCGTGCTTTGAA	0.388													0	0	0	1	0	59	113										T	9583767	C	T	9583767	3	4	18	1	0	0	0	0	1	0	0	0	3826	884	31	1	1257	1	CPSF3	2	9583767	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		9583767	233615606	63	4637										
NTSR2	23620	broad.mit.edu	37	chr2	11802148	11802148	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cggcgcacgtctttatgtctCaccaggctgacctggcctcc	10	16	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:11802148C>T	uc002rbq.3	-	2	917	c.843G>A	c.(841-843)GTG>GTA	p.V281V		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	281	Cytoplasmic (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	CTTTATGTCTCACCAGGCTGA	0.557													0	0	0	1	0	68	81										T	11802148	C	T	11802148	2	4	18	1	0	0	0	0	0	0	0	1	10711	813	29	1		1	NTSR2	2	11802148	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2218381	11802148	231397225	64	4638										
C2orf39	92749	broad.mit.edu	37	chr2	26624903	26624903	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccctggacccgaacgtggacGagcacttgtccacccagatt	10	15	0	1	rs149082901		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:26624903G>T	uc002rhg.2	+	1	120	c.46G>T	c.(46-48)GAG>TAG	p.E16*	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	16											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAACGTGGACGAGCACTTGTC	0.677													1	0	2.89027e-11	1	2.94798e-11	20	28										T	26624903	G	T	26624903	4	4	18	1	0	0	0	0	0	1	0	0	2164	1059	37	3	48	3	C2orf39	2	26624903	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	14822755	26624903	216574470	65	4639										
EMILIN1	11117	broad.mit.edu	37	chr2	27302012	27302012	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggccgccagctaccctcctCgaggtttcagcctctacaca	9	17	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:27302012C>G	uc002rii.3	+	1	507	c.79C>G	c.(79-81)CGA>GGA	p.R27G	EMILIN1_uc010eyq.1_Missense_Mutation_p.R27G	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	27					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTACCCTCCTCGAGGTTTCAG	0.716													0	0	0	1	0	12	18										G	27302012	C	G	27302012	3	3	18	1	0	0	0	0	1	0	0	0	5093	876	31	1	81	1	EMILIN1	2	27302012	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	677109	27302012	215897361	66	4640										
C2orf53	339779	broad.mit.edu	37	chr2	27360541	27360541	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgtgcgatgcggcggtgcccCagctggaccaccagggcctg	16	14	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:27360541C>T	uc002rjb.2	-	3	1237	c.657G>A	c.(655-657)CTG>CTA	p.L219L	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	219											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCGGTGCCCCAGCTGGACCA	0.662													0	0	0	1	0	36	33										T	27360541	C	T	27360541	2	4	18	1	0	0	0	0	0	0	0	1	2174	581	21	2		2	C2orf53	2	27360541	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	58529	27360541	215838832	67	4641										
ZNF513	130557	broad.mit.edu	37	chr2	27600419	27600419	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agaaggacctagttcaggatGagtctgtgtggacagcccgg	15	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:27600419G>T	uc002rkk.2	-	4	1819	c.1619C>A	c.(1618-1620)TCA>TAA	p.S540*	ZNF513_uc002rkj.2_Nonsense_Mutation_p.S478*	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	540					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTTCAGGATGAGTCTGTGTG	0.607													1	0	8.16277e-20	1	8.48098e-20	32	56										T	27600419	G	T	27600419	4	4	18	1	0	0	0	0	0	1	0	0	17955	1294	45	3	10	3	ZNF513	2	27600419	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	239878	27600419	215598954	68	4642										
BIRC6	57448	broad.mit.edu	37	chr2	32716581	32716581	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcatgtattagtgaaatttCtttctggcaccagtccacat	6	9	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:32716581C>G	uc010ezu.2	+	44	8430	c.8296C>G	c.(8296-8298)CTT>GTT	p.L2766V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2766					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGTGAAATTTCTTTCTGGCAC	0.398													0	0	0	1	0	72	101										G	32716581	C	G	32716581	3	3	18	1	0	0	0	0	1	0	0	0	1438	913	32	1	8470	1	BIRC6	2	32716581	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5116162	32716581	210482792	69	4643										
BIRC6	57448	broad.mit.edu	37	chr2	32740370	32740370	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagctattaaacaattactaGactcaggtttgccttctctt	5	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:32740370G>C	uc010ezu.2	+	55	11016	c.10882G>C	c.(10882-10884)GAC>CAC	p.D3628H		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3628					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ACAATTACTAGACTCAGGTTT	0.418													0	0	0	1	0	38	47										C	32740370	G	C	32740370	3	2	18	1	0	0	0	0	1	0	0	0	1438	942	33	1	11100	1	BIRC6	2	32740370	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	23789	32740370	210459003	70	4644										
SLC8A1	6546	broad.mit.edu	37	chr2	40656481	40656481	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcatcatcttggtccctctCatccacctccagaaccagag	5	16	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:40656481C>A	uc002rrx.2	-	1	964	c.940G>T	c.(940-942)GAG>TAG	p.E314*	SLC8A1_uc002rry.2_Nonsense_Mutation_p.E314*|SLC8A1_uc002rrz.2_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsa.2_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsd.3_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsb.1_Nonsense_Mutation_p.E314*|SLC8A1_uc010fan.1_Nonsense_Mutation_p.E314*|SLC8A1_uc002rsc.1_Nonsense_Mutation_p.E314*	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	314	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGGTCCCTCTCATCCACCTCC	0.413													1	0	1.46924e-35	1	1.56091e-35	83	129										A	40656481	C	A	40656481	4	1	18	1	0	0	0	0	0	1	0	0	14706	835	29	3	2129	3	SLC8A1	2	40656481	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7916111	40656481	202542892	71	4645										
SPTBN1	6711	broad.mit.edu	37	chr2	54859746	54859746	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatgcctaccaccttggaagGagctgaagcagcaattaaaa	9	9	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:54859746G>C	uc002rxu.2	+	17	3857	c.3608G>C	c.(3607-3609)GGA>GCA	p.G1203A	SPTBN1_uc002rxx.2_Missense_Mutation_p.G1190A	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1203	Spectrin 9.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACCTTGGAAGGAGCTGAAGCA	0.458													0	0	0	1	0	38	47										C	54859746	G	C	54859746	3	2	18	1	0	0	0	0	1	0	0	0	15118	1174	41	1	3783	1	SPTBN1	2	54859746	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	14203265	54859746	188339627	72	4646										
PUS10	150962	broad.mit.edu	37	chr2	61175207	61175207	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgagttttcaagtggaggcgGaagtggtgctcatccacgta	14	7	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:61175207G>A	uc010fci.2	-	16	1482	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	PUS10_uc002sao.2_Silent_p.F474F|PUS10_uc010ypk.1_Silent_p.F251F	NM_144709	NP_653310	Q3MIT2	PUS10_HUMAN	pseudouridylate synthase 10	474					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)			AGTGGAGGCGGAAGTGGTGCT	0.547													0	0	0	1	0	116	130										A	61175207	G	A	61175207	2	1	18	1	0	0	0	0	0	0	0	1	12831	1165	41	1		1	PUS10	2	61175207	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6315461	61175207	182024166	73	4647										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360405	71360405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgagagagctgaaaactcaaGcaaatctgatctgaggaaaa	10	6	3	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:71360405G>A	uc002sht.1	+	2	819	c.467G>A	c.(466-468)AGC>AAC	p.S156N	MPHOSPH10_uc010feb.1_Missense_Mutation_p.S156N	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	156					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GAAAACTCAAGCAAATCTGAT	0.448													0	0	0	1	0	59	76										A	71360405	G	A	71360405	3	1	18	1	0	0	0	0	1	0	0	0	9725	971	34	2	473	2	MPHOSPH10	2	71360405	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10185198	71360405	171838968	74	4648			1	14		3	3	237	G		8.229103e-06
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360599	71360599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tagaaaacatagaaaaagaaGaggaacgaaaagatgataat	9	2	0	6			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:71360599G>C	uc002sht.1	+	2	1013	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	MPHOSPH10_uc010feb.1_Missense_Mutation_p.E221Q	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	221	Potential.				RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						AGAAAAAGAAGAGGAACGAAA	0.338													0	0	0	1	0	40	33										C	71360599	G	C	71360599	3	2	18	1	0	0	0	0	1	0	0	0	9725	943	33	1	667	1	MPHOSPH10	2	71360599	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	194	71360599	171838774	75	4649			1	14		3	3	237	G		8.229103e-06
MPHOSPH10	10199	broad.mit.edu	37	chr2	71360641	71360641	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atgaggaggaggaagatattGatttttttgaagatattgat	12	0	0	6			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:71360641G>C	uc002sht.1	+	2	1055	c.703G>C	c.(703-705)GAT>CAT	p.D235H	MPHOSPH10_uc010feb.1_Missense_Mutation_p.D235H	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	235	Potential.				RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GGAAGATATTGATTTTTTTGA	0.343													0	0	0	1	0	49	52										C	71360641	G	C	71360641	3	2	18	1	0	0	0	0	1	0	0	0	9725	1290	45	1	709	1	MPHOSPH10	2	71360641	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	42	71360641	171838732	76	4650			1	14		3	3	237	G		8.229103e-06
MOGS	7841	broad.mit.edu	37	chr2	74689845	74689845	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggctctccagggcctgggtCagtagactgcctgccagtct	13	13	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:74689845C>T	uc010ffj.2	-	4	1234	c.1071G>A	c.(1069-1071)CTG>CTA	p.L357L	MOGS_uc010ffh.2_Silent_p.L82L|MOGS_uc010yrt.1_Silent_p.L238L|MOGS_uc010ffi.2_Silent_p.L251L	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	357	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GGGCCTGGGTCAGTAGACTGC	0.542													0	0	0	1	0	55	62										T	74689845	C	T	74689845	2	4	18	1	0	0	0	0	0	0	0	1	9697	813	29	1		1	MOGS	2	74689845	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3329204	74689845	168509528	77	4651										
HTRA2	27429	broad.mit.edu	37	chr2	74757145	74757145	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcggagctgatggctgcgccGagggcggggcggggtgcagg	24	9	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:74757145G>A	uc002smi.1	+	1	614	c.12G>A	c.(10-12)CCG>CCA	p.P4P	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.P4P|HTRA2_uc002smk.1_Silent_p.P4P|HTRA2_uc002sml.1_Silent_p.P4P|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	4					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGGCTGCGCCGAGGGCGGGGC	0.741													0	0	0	1	0	57	67										A	74757145	G	A	74757145	2	1	18	1	0	0	0	0	0	0	0	1	7454	1045	37	1		1	HTRA2	2	74757145	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	67300	74757145	168442228	78	4652										
SEMA4F	10505	broad.mit.edu	37	chr2	74907021	74907021	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggggcgggactggctggcttCttcttggggattctcgcagc	17	10	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:74907021C>T	uc002sna.1	+	14	2109	c.1998C>T	c.(1996-1998)TTC>TTT	p.F666F	SEMA4F_uc010ffr.1_Silent_p.F278F|SEMA4F_uc002snb.1_Silent_p.F278F|SEMA4F_uc002snc.1_Silent_p.F511F	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	666	Helical; (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGGCTGGCTTCTTCTTGGGGA	0.627													0	0	0	1	0	33	45										T	74907021	C	T	74907021	2	4	18	1	0	0	0	0	0	0	0	1	14035	912	32	1		1	SEMA4F	2	74907021	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	149876	74907021	168292352	79	4653										
KDM3A	55818	broad.mit.edu	37	chr2	86693893	86693894	+	Frame_Shift_Ins	INS	-	-	A													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agccctaataactgttcaggINSaaaaaaggtagaaccttcag							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:86693893_86693894insA	uc002sri.3	+	10	1733_1734	c.1406_1407insA	c.(1405-1407)GGAfs	p.G469fs	KDM3A_uc010ytj.1_Frame_Shift_Ins_p.G469fs|KDM3A_uc010ytk.1_Frame_Shift_Ins_p.G417fs	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	469					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						AACTGTTCAGGAAAAAAGGTAG	0.401																		41	87	---	---								A	86693894	-	A	86693893	7	5	18	1	0	1	1	0	0	0	0	0	8126	1174	41	0	1440	0	KDM3A	2	86693893	Frame_Shift_Ins	INS	-	TCGA-BT-A3PH-01A-11D-A21Z-08	11786872	86693893	156505480	80	4654										
KDM3A	55818	broad.mit.edu	37	chr2	86707394	86707394	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaagcagcctccaagccagcCggcagcatgaagcctgcctg	12	15	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:86707394C>T	uc002sri.3	+	16	2748	c.2421C>T	c.(2419-2421)GCC>GCT	p.A807A	KDM3A_uc010ytj.1_Silent_p.A807A|KDM3A_uc010ytk.1_Silent_p.A755A	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	807					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						CCAAGCCAGCCGGCAGCATGA	0.567													0	0	0	1	0	25	22										T	86707394	C	T	86707394	2	4	18	1	0	0	0	0	0	0	0	1	8126	639	23	2		2	KDM3A	2	86707394	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	13501	86707394	156491979	81	4655										
ANKRD36B	57730	broad.mit.edu	37	chr2	98206122	98206122	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atgtagtaatggggaaatgcGaagccatccgagcacaagcg	13	8	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:98206122G>A	uc010yvc.1	-	1	307	c.27C>T	c.(25-27)TTC>TTT	p.F9F	ANKRD36B_uc010yve.1_RNA|ANKRD36B_uc010fif.2_RNA	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B	9											0						GGGGAAATGCGAAGCCATCCG	0.512													0	0	0	1	0	30	47										A	98206122	G	A	98206122	2	1	18	1	0	0	0	0	0	0	0	1	666	1049	37	1		1	ANKRD36B	2	98206122	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11498728	98206122	144993251	82	4656										
POU3F3	5455	broad.mit.edu	37	chr2	105472929	105472929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggacacgccgacgtcggacGacctggagcagttcgccaag	14	13	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:105472929G>A	uc010ywg.1	+	1	961	c.961G>A	c.(961-963)GAC>AAC	p.D321N		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	321	POU-specific.				metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						GACGTCGGACGACCTGGAGCA	0.617													0	0	0	1	0	34	34										A	105472929	G	A	105472929	3	1	18	1	0	0	0	0	1	0	0	0	12276	1058	37	1	963	1	POU3F3	2	105472929	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7266807	105472929	137726444	83	4657										
DPP10	57628	broad.mit.edu	37	chr2	116485505	116485505	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatgggattgctgactggttAtatgaaggtgagttgatcag	14	3	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:116485505A>G	uc002tla.1	+	8	1147	c.690A>G	c.(688-690)TTA>TTG	p.L230L	DPP10_uc002tlb.1_Silent_p.L180L|DPP10_uc002tlc.1_Silent_p.L226L|DPP10_uc002tle.2_Silent_p.L234L|DPP10_uc002tlf.1_Silent_p.L223L	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	230	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CTGACTGGTTATATGAAGGTG	0.299													0	0	0	1	0	19	19										G	116485505	A	G	116485505	2	3	18	1	0	0	0	0	0	0	0	1	4727	446	16	5		5	DPP10	2	116485505	Silent	SNP	A	TCGA-BT-A3PH-01A-11D-A21Z-08	11012576	116485505	126713868	84	4658										
DDX18	8886	broad.mit.edu	37	chr2	118577326	118577326	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggagaagccagataatgatGaagatgagagtgaggtgccc	15	5	0	7			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:118577326G>A	uc002tlh.1	+	3	571	c.472G>A	c.(472-474)GAA>AAA	p.E158K		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	158							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						AGATAATGATGAAGATGAGAG	0.413											OREG0003814	type=REGULATORY REGION|Gene=DDX18|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	1	0	17	45										A	118577326	G	A	118577326	3	1	18	1	0	0	0	0	1	0	0	0	4345	1291	45	1	482	1	DDX18	2	118577326	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2091821	118577326	124622047	85	4659										
CNTNAP5	129684	broad.mit.edu	37	chr2	125555701	125555701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctgtttttgaggctggcacGtcggttacttacatgtttca	11	8	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:125555701G>A	uc002tno.2	+	19	3382	c.3018G>A	c.(3016-3018)ACG>ACA	p.T1006T	CNTNAP5_uc010flu.2_Silent_p.T1007T	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1006	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGGCTGGCACGTCGGTTACTT	0.423													0	0	0	1	0	8	6										A	125555701	G	A	125555701	2	1	18	1	0	0	0	0	0	0	0	1	3650	1132	40	2		2	CNTNAP5	2	125555701	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6978375	125555701	117643672	86	4660										
UGGT1	56886	broad.mit.edu	37	chr2	128935411	128935411	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cacatttgattgcaggttcaGaagaaggcagatatggtgaa	12	5	1	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:128935411G>C	uc002tps.2	+	33	3808	c.3630G>C	c.(3628-3630)CAG>CAC	p.Q1210H	UGGT1_uc002tpr.2_Missense_Mutation_p.Q1186H	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1210					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TGCAGGTTCAGAAGAAGGCAG	0.418													0	0	0	1	0	96	288										C	128935411	G	C	128935411	3	2	18	1	0	0	0	0	1	0	0	0	16938	933	33	1	3760	1	UGGT1	2	128935411	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3379710	128935411	114263962	87	4661										
SMPD4	55627	broad.mit.edu	37	chr2	130911411	130911411	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggagctaaagcccagccatGagaggaaggagtggccagcc	15	10	0	1	rs142449057		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:130911411G>C	uc002tqq.1	-	17	2394	c.1874C>G	c.(1873-1875)TCA>TGA	p.S625*	SMPD4_uc002tqo.1_Nonsense_Mutation_p.S157*|SMPD4_uc002tqp.1_Nonsense_Mutation_p.S364*|SMPD4_uc010yzy.1_Nonsense_Mutation_p.S374*|SMPD4_uc010yzz.1_Nonsense_Mutation_p.S289*|SMPD4_uc002tqr.1_Nonsense_Mutation_p.S596*|SMPD4_uc002tqs.1_Nonsense_Mutation_p.S493*|SMPD4_uc002tqt.1_Nonsense_Mutation_p.S474*|SMPD4_uc010zaa.1_Nonsense_Mutation_p.S483*|SMPD4_uc010zab.1_Nonsense_Mutation_p.S523*|SMPD4_uc010zac.1_Nonsense_Mutation_p.S366*|SMPD4_uc010zad.1_Nonsense_Mutation_p.S261*	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	586					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GCCCAGCCATGAGAGGAAGGA	0.592													0	0	0	1	0	138	76										C	130911411	G	C	130911411	4	2	18	1	0	0	0	0	0	1	0	0	14807	1294	45	1	742	1	SMPD4	2	130911411	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1976000	130911411	112287962	88	4662										
ACMSD	130013	broad.mit.edu	37	chr2	135655919	135655919	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttgttttttaggataaagtCattttgggaaccgattaccc	8	6	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:135655919C>T	uc002ttz.2	+	9	925	c.858C>T	c.(856-858)GTC>GTT	p.V286V	ACMSD_uc002tua.2_Silent_p.V228V|uc010zbe.1_Intron	NM_138326	NP_612199	Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	286					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.115)		AGGATAAAGTCATTTTGGGAA	0.343													0	0	0	1	0	277	37										T	135655919	C	T	135655919	2	4	18	1	0	0	0	0	0	0	0	1	144	813	29	1		1	ACMSD	2	135655919	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4744508	135655919	107543454	89	4663										
XIRP2	129446	broad.mit.edu	37	chr2	168104227	168104227	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgagagagctgaagaaggatGatgtctttaattccatccaa	10	6	1	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:168104227G>A	uc002udx.2	+	8	6343	c.6325G>A	c.(6325-6327)GAT>AAT	p.D2109N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D1934N|XIRP2_uc010fpq.2_Missense_Mutation_p.D1887N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1934					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAAGAAGGATGATGTCTTTAA	0.368													0	0	0	1	0	39	10										A	168104227	G	A	168104227	3	1	18	1	0	0	0	0	1	0	0	0	17427	1290	45	1	6355	1	XIRP2	2	168104227	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	32448308	168104227	75095146	90	4664										
TTN	7273	broad.mit.edu	37	chr2	179406276	179406276	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	catgccatcacgggaaacatCaaatatctgtaatgtttctg	7	9	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:179406276C>G	uc010zfg.1	-	299	90048	c.89824G>C	c.(89824-89826)GAT>CAT	p.D29942H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D23637H|TTN_uc010zfi.1_Missense_Mutation_p.D23570H|TTN_uc010zfj.1_Missense_Mutation_p.D23445H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30869							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGGAAACATCAAATATCTGT	0.443													0	0	0	1	0	11	3										G	179406276	C	G	179406276	3	3	18	1	0	0	0	0	1	0	0	0	16732	826	29	1	10503	1	TTN	2	179406276	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	11302049	179406276	63793097	91	4665										
TTN	7273	broad.mit.edu	37	chr2	179435914	179435914	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgatgttctctgcagagactCtaaattcatattcaacacct	5	11	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:179435914C>G	uc010zfg.1	-	275	67465	c.67241G>C	c.(67240-67242)AGA>ACA	p.R22414T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R16109T|TTN_uc010zfi.1_Missense_Mutation_p.R16042T|TTN_uc010zfj.1_Missense_Mutation_p.R15917T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23341							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAGAGACTCTAAATTCATA	0.443													0	0	0	1	0	61	18										G	179435914	C	G	179435914	3	3	18	1	0	0	0	0	1	0	0	0	16732	913	32	1	33182	1	TTN	2	179435914	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	29638	179435914	63763459	92	4666										
CCDC141	285025	broad.mit.edu	37	chr2	179701672	179701673	+	Missense_Mutation	DNP	GG	GG	AA													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttcaacttccaaagtcactGgagaaccttccatgacagtt							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:179701672_179701673GG>AA	uc002unf.1	-	13	2605_2606	c.2548_2549CC>TT	c.(2548-2550)CCA>TTA	p.P850L	CCDC141_uc002une.1_Missense_Mutation_p.P300L	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	850	Ig-like.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CAAAGTCACTGGAGAACCTTCC	0.446													0	0	0	1	0	28	8										AA	179701673	GG	AA	179701672	3	1	18	1	0	0	0	0	1	0	0	0	2775	1348	47	2	82	2	CCDC141	2	179701672	Missense_Mutation	DNP	GG	TCGA-BT-A3PH-01A-11D-A21Z-08	265758	179701672	63497701	93	4667										
CERKL	375298	broad.mit.edu	37	chr2	182430845	182430845	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagcgtgcccttcatattccAttactattaaaaaaacacac	4	11	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:182430845A>G	uc002unx.2	-	4	718	c.617T>C	c.(616-618)ATG>ACG	p.M206T	CERKL_uc002uny.2_Missense_Mutation_p.M206T|CERKL_uc010zfm.1_Missense_Mutation_p.M162T|CERKL_uc002unz.2_Intron|CERKL_uc002uoa.2_Intron|CERKL_uc002uob.2_Intron|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_Intron|CERKL_uc002uod.1_Missense_Mutation_p.M1T|CERKL_uc002uoe.2_Missense_Mutation_p.M206T	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	206	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTCATATTCCATTACTATTAA	0.308													0	0	0	1	0	46	9										G	182430845	A	G	182430845	3	3	18	1	0	0	0	0	1	0	0	0	3268	217	8	5	1103	5	CERKL	2	182430845	Missense_Mutation	SNP	A	TCGA-BT-A3PH-01A-11D-A21Z-08	2729173	182430845	60768528	94	4668										
ASNSD1	54529	broad.mit.edu	37	chr2	190532598	190532598	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgaataaggaaataatgatgGaactgggtcgaatttcttct	10	4	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:190532598G>C	uc002uqt.2	+	5	2007	c.1573G>C	c.(1573-1575)GAA>CAA	p.E525Q		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	525	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			AATAATGATGGAACTGGGTCG	0.413													0	0	0	1	0	65	12										C	190532598	G	C	190532598	3	2	18	1	0	0	0	0	1	0	0	0	1049	1175	41	1	1579	1	ASNSD1	2	190532598	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	8101753	190532598	52666775	95	4669										
CLK1	1195	broad.mit.edu	37	chr2	201718103	201718103	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtaattcttttggctggatCatactccaacattttctgaa	6	8	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:201718103C>T	uc002uwe.2	-	13	1562	c.1381G>A	c.(1381-1383)GAT>AAT	p.D461N	CLK1_uc002uwd.2_Missense_Mutation_p.D284N|CLK1_uc010zhi.1_Missense_Mutation_p.D503N|CLK1_uc002uwf.2_Missense_Mutation_p.D235N|CLK1_uc002uwg.2_Missense_Mutation_p.D310N|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	461	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TTGGCTGGATCATACTCCAAC	0.368													0	0	0	1	0	35	11										T	201718103	C	T	201718103	3	4	18	1	0	0	0	0	1	0	0	0	3536	826	29	1	77	1	CLK1	2	201718103	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	11185505	201718103	41481270	96	4670										
CCDC108	255101	broad.mit.edu	37	chr2	219900268	219900268	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gattccttgtggtctcctttCctagctcccagcctttccaa	6	15	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:219900268C>G	uc002vjl.1	-	5	560	c.476G>C	c.(475-477)GGA>GCA	p.G159A	CCDC108_uc010zkp.1_Missense_Mutation_p.G148A|CCDC108_uc010zkq.1_Missense_Mutation_p.G94A|CCDC108_uc002vjn.2_Missense_Mutation_p.G94A	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	159						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTCTCCTTTCCTAGCTCCCA	0.502													0	0	0	1	0	77	26										G	219900268	C	G	219900268	3	3	18	1	0	0	0	0	1	0	0	0	2743	855	30	1	5573	1	CCDC108	2	219900268	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	18182165	219900268	23299105	97	4671										
ALPI	248	broad.mit.edu	37	chr2	233321358	233321358	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agaatggcaaactggggcctGagacgcccctggccatggac	14	12	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:233321358G>C	uc002vst.3	+	3	330	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	ALPI_uc002vsu.3_5'UTR	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	85					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ACTGGGGCCTGAGACGCCCCT	0.607													0	0	0	1	0	13	1										C	233321358	G	C	233321358	3	2	18	1	0	0	0	0	1	0	0	0	543	1291	45	1	263	1	ALPI	2	233321358	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	13421090	233321358	9878015	98	4672										
AGAP1	116987	broad.mit.edu	37	chr2	236957880	236957880	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctagccaacagcgtctgggAagagagcagccaggggcgga	17	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr2:236957880A>G	uc002vvs.2	+	16	2664	c.2069A>G	c.(2068-2070)GAA>GGA	p.E690G	AGAP1_uc002vvt.2_Missense_Mutation_p.E637G	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	690	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						AGCGTCTGGGAAGAGAGCAGC	0.567													0	0	0	1	0	45	11										G	236957880	A	G	236957880	3	3	18	1	0	0	0	0	1	0	0	0	366	246	9	5	2131	5	AGAP1	2	236957880	Missense_Mutation	SNP	A	TCGA-BT-A3PH-01A-11D-A21Z-08	3636522	236957880	6241493	99	4673										
SH3BP5	9467	broad.mit.edu	37	chr3	15300495	15300495	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccaggttcttcagggccatCttgtactcgccttttgccag	9	13	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:15300495C>G	uc003bzp.1	-	7	921	c.732G>C	c.(730-732)AAG>AAC	p.K244N	SH3BP5_uc010hem.1_Intron|SH3BP5_uc003bzq.1_Missense_Mutation_p.K87N|SH3BP5_uc003bzr.1_Missense_Mutation_p.K87N|uc003bzo.1_RNA	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	244					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						TCAGGGCCATCTTGTACTCGC	0.557													0	0	0	1	0	46	62										G	15300495	C	G	15300495	3	3	18	1	0	0	0	0	1	0	0	0	14247	912	32	1	647	1	SH3BP5	3	15300495	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		15300495	182721935	100	4674										
EOMES	8320	broad.mit.edu	37	chr3	27761760	27761760	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccacctctacgaacacattgTagtgggcagtgggattgagt	12	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:27761760T>C	uc003cdx.2	-	2	938	c.938A>G	c.(937-939)TAC>TGC	p.Y313C	EOMES_uc003cdy.3_Missense_Mutation_p.Y313C|EOMES_uc010hfn.2_Missense_Mutation_p.Y313C|EOMES_uc011axc.1_Missense_Mutation_p.Y18C	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	313	T-box.				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						GAACACATTGTAGTGGGCAGT	0.502													0	0	0	1	0	194	234										C	27761760	T	C	27761760	3	2	18	1	0	0	0	0	1	0	0	0	5147	1638	57	5	1142	5	EOMES	3	27761760	Missense_Mutation	SNP	T	TCGA-BT-A3PH-01A-11D-A21Z-08	12461265	27761760	170260670	101	4675										
GOLGA4	2803	broad.mit.edu	37	chr3	37388779	37388779	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgagtatatgatgggtcgtGagactaaggtataaatcatg	12	3	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:37388779G>C	uc003cgv.2	+	21	6872	c.6568G>C	c.(6568-6570)GAG>CAG	p.E2190Q	GOLGA4_uc003cgw.2_Missense_Mutation_p.E2205Q|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.E2071Q	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2190	GRIP.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GATGGGTCGTGAGACTAAGGT	0.373													0	0	0	1	0	70	91										C	37388779	G	C	37388779	3	2	18	1	0	0	0	0	1	0	0	0	6555	1291	45	1	6720	1	GOLGA4	3	37388779	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	9627019	37388779	160633651	102	4676										
XIRP1	165904	broad.mit.edu	37	chr3	39226133	39226133	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgcagtttgacctccgacctCctggcctgagccactgggcc	11	16	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:39226133C>G	uc003cjk.1	-	2	5025	c.4804G>C	c.(4804-4806)GAG>CAG	p.E1602Q	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.E285Q	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1602							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCTCCGACCTCCTGGCCTGAG	0.562													0	0	0	1	0	190	177										G	39226133	C	G	39226133	3	3	18	1	0	0	0	0	1	0	0	0	17426	864	30	1	731	1	XIRP1	3	39226133	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1837354	39226133	158796297	103	4677										
CELSR3	1951	broad.mit.edu	37	chr3	48664109	48664109	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cacctcaatctcccggaagtCatggaaaatctgtagcggaa	9	11	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:48664109C>T	uc003cuf.1	-	54	12241	c.12241G>A	c.(12241-12243)GAC>AAC	p.D4081N	SLC26A6_uc003cug.2_Missense_Mutation_p.D674N|SLC26A6_uc003cuh.2_Missense_Mutation_p.D695N|SLC26A6_uc010hke.2_Missense_Mutation_p.D527N|SLC26A6_uc003cuk.2_Missense_Mutation_p.D587N|SLC26A6_uc003cui.2_Missense_Mutation_p.D694N|SLC26A6_uc003cuj.2_Missense_Mutation_p.D676N|SLC26A6_uc011bbp.1_Missense_Mutation_p.D659N	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCCCGGAAGTCATGGAAAATC	0.602													0	0	0	1	0	166	307										T	48664109	C	T	48664109	3	4	18	1	0	0	0	0	1	0	0	0	3223	826	29	1		1	CELSR3	3	48664109	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	9437976	48664109	149358321	104	4678										
USP4	7375	broad.mit.edu	37	chr3	49339954	49339954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctggtagccagaaaattgagGagcaaaacgtcctacttgag	11	8	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:49339954G>A	uc003cwq.2	-	10	1229	c.1150C>T	c.(1150-1152)CCT>TCT	p.P384S	USP4_uc003cwo.2_Missense_Mutation_p.P114S|USP4_uc003cwp.2_Missense_Mutation_p.P114S|USP4_uc003cwr.2_Missense_Mutation_p.P337S	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	384					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GAAAATTGAGGAGCAAAACGT	0.388													0	0	0	1	0	49	34										A	49339954	G	A	49339954	3	1	18	1	0	0	0	0	1	0	0	0	17068	1174	41	1	1793	1	USP4	3	49339954	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	675845	49339954	148682476	105	4679										
MST1	4485	broad.mit.edu	37	chr3	49724610	49724610	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caggatttgatgccgcagctCtggaagcgcacagcagggtc	14	11	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:49724610C>G	uc003cxg.2	-	5	651	c.579G>C	c.(577-579)CAG>CAC	p.Q193H	MST1_uc011bcs.1_Missense_Mutation_p.Q193H|MST1_uc010hkx.2_Missense_Mutation_p.Q114H|MST1_uc011bct.1_Missense_Mutation_p.Q193H|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	179	Kringle 1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGCCGCAGCTCTGGAAGCGCA	0.622													0	0	0	1	0	36	67										G	49724610	C	G	49724610	3	3	18	1	0	0	0	0	1	0	0	0	9890	912	32	1	1654	1	MST1	3	49724610	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	384656	49724610	148297820	106	4680										
DNAH1	25981	broad.mit.edu	37	chr3	52382979	52382979	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcatgagccactggtggaaGagctacgggccaccattgcc	12	12	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52382979G>C	uc011bef.1	+	13	2443	c.2182G>C	c.(2182-2184)GAG>CAG	p.E728Q	DNAH1_uc003ddt.1_Missense_Mutation_p.E728Q	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	728	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACTGGTGGAAGAGCTACGGGC	0.592													0	0	0	1	0	96	123										C	52382979	G	C	52382979	3	2	18	1	0	0	0	0	1	0	0	0	4597	943	33	1	2228	1	DNAH1	3	52382979	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2658369	52382979	145639451	107	4681										
NT5DC2	64943	broad.mit.edu	37	chr3	52561907	52561907	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccatgggccaccaggcggctCaggacagcaaacgtctcatc	11	15	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52561907C>G	uc003deo.2	-	8	1186	c.762G>C	c.(760-762)CTG>CTC	p.L254L	NT5DC2_uc003dem.2_Silent_p.L124L|NT5DC2_uc003den.2_Silent_p.L291L|NT5DC2_uc010hmi.2_Silent_p.L266L|NT5DC2_uc010hmj.2_Silent_p.L70L	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	254							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		CCAGGCGGCTCAGGACAGCAA	0.602													0	0	0	1	0	49	106										G	52561907	C	G	52561907	2	3	18	1	0	0	0	0	0	0	0	1	10691	813	29	1		1	NT5DC2	3	52561907	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	178928	52561907	145460523	108	4682										
PBRM1	55193	broad.mit.edu	37	chr3	52613209	52613209	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	catttccacagggacatcttCtttttcctgttgtaaagaaa	6	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52613209C>T	uc003des.2	-	21	3406	c.3394G>A	c.(3394-3396)GAA>AAA	p.E1132K	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E1132K|PBRM1_uc003der.2_Missense_Mutation_p.E1100K|PBRM1_uc003det.2_Missense_Mutation_p.E1147K|PBRM1_uc003deu.2_Missense_Mutation_p.E1147K|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E1132K|PBRM1_uc010hmk.1_Missense_Mutation_p.E1107K|PBRM1_uc003dey.2_Missense_Mutation_p.E1107K|PBRM1_uc003dez.1_Missense_Mutation_p.E1131K	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1132					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.E1132fs*27(1)		kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGGACATCTTCTTTTTCCTGT	0.408			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	56	75										T	52613209	C	T	52613209	3	4	18	1	0	0	0	0	1	0	0	0	11491	922	32	1	1546	1	PBRM1	3	52613209	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	51302	52613209	145409221	109	4683										
PBRM1	55193	broad.mit.edu	37	chr3	52643597	52643597	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atttgggacatgagagtcctCatctccctccaggtctctgc	9	13	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52643597C>G	uc003des.2	-	16	2311	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E767Q|PBRM1_uc003der.2_Missense_Mutation_p.E735Q|PBRM1_uc003det.2_Missense_Mutation_p.E782Q|PBRM1_uc003deu.2_Missense_Mutation_p.E782Q|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E767Q|PBRM1_uc010hmk.1_Missense_Mutation_p.E767Q|PBRM1_uc003dey.2_Missense_Mutation_p.E767Q|PBRM1_uc003dez.1_Missense_Mutation_p.E767Q|PBRM1_uc003dfb.1_Missense_Mutation_p.E680Q|PBRM1_uc003dfa.1_Missense_Mutation_p.E113Q|PBRM1_uc003dfc.2_Missense_Mutation_p.E134Q	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	767					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TGAGAGTCCTCATCTCCCTCC	0.438			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	43	25										G	52643597	C	G	52643597	3	3	18	1	0	0	0	0	1	0	0	0	11491	835	29	1	2661	1	PBRM1	3	52643597	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	30388	52643597	145378833	110	4684										
ITIH1	3697	broad.mit.edu	37	chr3	52820325	52820325	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctcaggagggacaagaattCagtataacctgcctagtgga	11	8	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:52820325C>A	uc003dfs.2	+	13	1632	c.1608C>A	c.(1606-1608)TTC>TTA	p.F536L	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Missense_Mutation_p.F137L|ITIH1_uc010hmo.1_Missense_Mutation_p.F90L|ITIH1_uc003dfu.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	536	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GACAAGAATTCAGTATAACCT	0.582													1	0	0.0477658	1	0.0478438	6	3										A	52820325	C	A	52820325	3	1	18	1	0	0	0	0	1	0	0	0	7903	825	29	3	1658	3	ITIH1	3	52820325	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	176728	52820325	145202105	111	4685										
LRIG1	26018	broad.mit.edu	37	chr3	66501996	66501996	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cacttacagaaagagagagaCgacatgtgatgaagcagcgc	12	8	0	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:66501996C>T	uc003dmx.2	-	3	366	c.352G>A	c.(352-354)GTC>ATC	p.V118I	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Missense_Mutation_p.V118I	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	118	Extracellular (Potential).|LRR 3.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		AAGAGAGAGACGACATGTGAT	0.483													0	0	0	1	0	97	227										T	66501996	C	T	66501996	3	4	18	1	0	0	0	0	1	0	0	0	8944	536	19	2	2997	2	LRIG1	3	66501996	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	13681671	66501996	131520434	112	4686										
OR5H6	79295	broad.mit.edu	37	chr3	97983819	97983819	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttttaccattggaactattCttatatcttatacaattatc	2	7	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:97983819C>G	uc003dsi.1	+	1	691	c.691C>G	c.(691-693)CTT>GTT	p.L231V		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	231	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TGGAACTATTCTTATATCTTA	0.338													0	0	0	1	0	21	31										G	97983819	C	G	97983819	3	3	18	1	0	0	0	0	1	0	0	0	11163	913	32	1	693	1	OR5H6	3	97983819	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	31481823	97983819	100038611	113	4687										
ABI3BP	25890	broad.mit.edu	37	chr3	100569525	100569525	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagtgttgcccttggctgttCaagagttctagaagttttag	11	7	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:100569525C>G	uc003dun.2	-	14	1364	c.1279G>C	c.(1279-1281)GAA>CAA	p.E427Q	ABI3BP_uc003duo.2_Missense_Mutation_p.E469Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	427	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						CTTGGCTGTTCAAGAGTTCTA	0.358													0	0	0	1	0	32	67										G	100569525	C	G	100569525	3	3	18	1	0	0	0	0	1	0	0	0	91	835	29	1	2036	1	ABI3BP	3	100569525	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2585706	100569525	97452905	114	4688										
PCNP	57092	broad.mit.edu	37	chr3	101304305	101304305	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctaaagaaactgttccaactCttgctccaaaaactctttca	3	12	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:101304305C>G	uc003dva.2	+	3	322	c.304C>G	c.(304-306)CTT>GTT	p.L102V	PCNP_uc003dvb.2_RNA|PCNP_uc003dvc.2_RNA|PCNP_uc003dvd.2_Missense_Mutation_p.L102V	NM_020357	NP_065090	Q8WW12	PCNP_HUMAN	PEST proteolytic signal containing nuclear	102					cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding				0						TGTTCCAACTCTTGCTCCAAA	0.284													0	0	0	1	0	61	45										G	101304305	C	G	101304305	3	3	18	1	0	0	0	0	1	0	0	0	11589	913	32	1	314	1	PCNP	3	101304305	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	734780	101304305	96718125	115	4689										
RPL24	6152	broad.mit.edu	37	chr3	101399989	101399989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atctgccagtttagcgttttCcaccaactcggggagctgaa	10	11	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:101399989C>T	uc003dvh.1	-	6	507	c.464G>A	c.(463-465)GGA>GAA	p.G155E	RPL24_uc003dvi.1_3'UTR	NM_000986	NP_000977	P83731	RL24_HUMAN	ribosomal protein L24	155					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TTAGCGTTTTCCACCAACTCG	0.378													0	0	0	1	0	151	132										T	101399989	C	T	101399989	3	4	18	1	0	0	0	0	1	0	0	0	13572	855	30	1	13	1	RPL24	3	101399989	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	95684	101399989	96622441	116	4690										
CCDC54	84692	broad.mit.edu	37	chr3	107096817	107096817	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aacgactaaagatatcctctCtatgaaagaagacatcaagg	7	8	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:107096817C>G	uc003dwi.1	+	1	630	c.383C>G	c.(382-384)TCT>TGT	p.S128C		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	128	Potential.										0						GATATCCTCTCTATGAAAGAA	0.393													0	0	0	1	0	29	30										G	107096817	C	G	107096817	3	3	18	1	0	0	0	0	1	0	0	0	2824	913	32	1	385	1	CCDC54	3	107096817	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5696828	107096817	90925613	117	4691										
CD47	961	broad.mit.edu	37	chr3	107798974	107798974	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctccttttagtaattgtgaGacttcaatttttgcactact	5	8	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:107798974G>A	uc003dwt.1	-	2	444	c.264C>T	c.(262-264)GTC>GTT	p.V88V	CD47_uc003dwu.1_Silent_p.V88V|CD47_uc003dwv.1_Silent_p.V88V|CD47_uc003dww.1_Silent_p.V88V	NM_001777	NP_001768	Q08722	CD47_HUMAN	CD47 antigen isoform 1 precursor	88	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			GTAATTGTGAGACTTCAATTT	0.383													0	0	0	1	0	62	104										A	107798974	G	A	107798974	2	1	18	1	0	0	0	0	0	0	0	1	3019	929	33	1		1	CD47	3	107798974	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	702157	107798974	90223456	118	4692										
MYH15	22989	broad.mit.edu	37	chr3	108163567	108163567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagttcctccctctgaaactCtgatttctccaaggctttct	5	14	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:108163567C>G	uc003dxa.1	-	23	2692	c.2635G>C	c.(2635-2637)GAG>CAG	p.E879Q		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	879	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CTCTGAAACTCTGATTTCTCC	0.438													0	0	0	1	0	97	78										G	108163567	C	G	108163567	3	3	18	1	0	0	0	0	1	0	0	0	10034	922	32	1	3285	1	MYH15	3	108163567	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	364593	108163567	89858863	119	4693										
UPK1B	7348	broad.mit.edu	37	chr3	118906732	118906732	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gacatctatggggctgcctgGatcggcatatttgtgggcat	14	8	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:118906732G>A	uc003ecc.2	+	3	269	c.180G>A	c.(178-180)TGG>TGA	p.W60*	UPK1B_uc011bix.1_5'UTR|UPK1B_uc003ecd.2_Nonsense_Mutation_p.W60*	NM_006952	NP_008883	O75841	UPK1B_HUMAN	uroplakin 1B	60	Extracellular (Potential).				epithelial cell differentiation	integral to membrane	structural molecule activity				0				GBM - Glioblastoma multiforme(114;0.222)		GGGCTGCCTGGATCGGCATAT	0.517													0	0	0	1	0	71	153										A	118906732	G	A	118906732	4	1	18	1	0	0	0	0	0	1	0	0	17005	1183	41	1	186	1	UPK1B	3	118906732	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10743165	118906732	79115698	120	4694										
POLQ	10721	broad.mit.edu	37	chr3	121179028	121179028	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acgacgatcatgggataaatGagccaagatcctcagttcaa	9	9	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:121179028G>A	uc003eee.3	-	25	7150	c.7021C>T	c.(7021-7023)CAT>TAT	p.H2341Y	POLQ_uc003eed.2_Missense_Mutation_p.H1513Y	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2341					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGGGATAAATGAGCCAAGATC	0.428								DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	72	63										A	121179028	G	A	121179028	3	1	18	1	0	0	0	0	1	0	0	0	12208	1290	45	1	775	1	POLQ	3	121179028	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2272296	121179028	76843402	121	4695										
POLQ	10721	broad.mit.edu	37	chr3	121187223	121187223	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cctactagtgttggcattttGatttcaaaatctcttggcac	7	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:121187223G>C	uc003eee.3	-	23	6903	c.6774C>G	c.(6772-6774)ATC>ATG	p.I2258M	POLQ_uc003eed.2_Missense_Mutation_p.I1430M	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2258					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TTGGCATTTTGATTTCAAAAT	0.383								DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	81	140										C	121187223	G	C	121187223	3	2	18	1	0	0	0	0	1	0	0	0	12208	1280	45	1	1030	1	POLQ	3	121187223	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	8195	121187223	76835207	122	4696										
CD86	942	broad.mit.edu	37	chr3	121822489	121822489	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaccaggaaaacttggttctGaatgaggtatacttaggcaa	11	6	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:121822489G>C	uc003eet.2	+	3	311	c.195G>C	c.(193-195)CTG>CTC	p.L65L	CD86_uc011bjo.1_5'UTR|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Silent_p.L59L	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	65	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	ACTTGGTTCTGAATGAGGTAT	0.438													0	0	0	1	0	110	108										C	121822489	G	C	121822489	2	2	18	1	0	0	0	0	0	0	0	1	3043	1277	45	1		1	CD86	3	121822489	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	635266	121822489	76199941	123	4697										
ADCY5	111	broad.mit.edu	37	chr3	123019119	123019119	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acggagcaggccagcaggctGagcagcacgctgtaggtgaa	16	10	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:123019119G>A	uc003egh.1	-	15	2748	c.2748C>T	c.(2746-2748)CTC>CTT	p.L916L	ADCY5_uc003egg.1_Silent_p.L549L|ADCY5_uc003egi.1_Silent_p.L475L	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	916	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CCAGCAGGCTGAGCAGCACGC	0.652													0	0	0	1	0	44	40										A	123019119	G	A	123019119	2	1	18	1	0	0	0	0	0	0	0	1	297	1277	45	1		1	ADCY5	3	123019119	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1196630	123019119	75003311	124	4698										
COL6A6	131873	broad.mit.edu	37	chr3	130287162	130287162	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	accctgactggtagtgccctGagctttgtgtctcagtactt	10	11	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:130287162G>C	uc010htl.2	+	5	2146	c.2115G>C	c.(2113-2115)CTG>CTC	p.L705L		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	705	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GTAGTGCCCTGAGCTTTGTGT	0.488													0	0	0	1	0	124	102										C	130287162	G	C	130287162	2	2	18	1	0	0	0	0	0	0	0	1	3703	1277	45	1		1	COL6A6	3	130287162	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7268043	130287162	67735268	125	4699										
PCOLCE2	26577	broad.mit.edu	37	chr3	142557645	142557645	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caccacaatactttccaattCttctagcatcgttgacttcc	3	14	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:142557645C>G	uc003evd.2	-	5	873	c.677G>C	c.(676-678)AGA>ACA	p.R226T		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	226	CUB 2.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						CTTTCCAATTCTTCTAGCATC	0.383													0	0	0	1	0	73	83										G	142557645	C	G	142557645	3	3	18	1	0	0	0	0	1	0	0	0	11595	913	32	1	590	1	PCOLCE2	3	142557645	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	12270483	142557645	55464785	126	4700										
CPA3	1359	broad.mit.edu	37	chr3	148596271	148596271	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagagattgagaaacagtttGatgttaaagaagatatccca	9	4	0	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:148596271G>C	uc003ewm.2	+	4	365	c.313G>C	c.(313-315)GAT>CAT	p.D105H		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	105					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			GAAACAGTTTGATGTTAAAGA	0.338													0	0	0	1	0	86	66										C	148596271	G	C	148596271	3	2	18	1	0	0	0	0	1	0	0	0	3791	1290	45	1	327	1	CPA3	3	148596271	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6038626	148596271	49426159	127	4701										
HPS3	84343	broad.mit.edu	37	chr3	148876575	148876575	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	attacagaaatacgagagagGattaatcttttacattaatc	6	5	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:148876575G>A	uc003ewu.1	+	10	1954	c.1814G>A	c.(1813-1815)GGA>GAA	p.G605E	HPS3_uc011bnq.1_Missense_Mutation_p.G440E|HPS3_uc003ewv.1_5'Flank	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	605						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TACGAGAGAGGATTAATCTTT	0.348									Hermansky-Pudlak_syndrome				0	0	0	1	0	45	84										A	148876575	G	A	148876575	3	1	18	1	0	0	0	0	1	0	0	0	7340	1174	41	1	1852	1	HPS3	3	148876575	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	280304	148876575	49145855	128	4702										
KPNA4	3840	broad.mit.edu	37	chr3	160253311	160253311	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcaacttacctagcagcttGaactgcacttaattgaattc	5	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:160253311G>A	uc003fdn.2	-	5	583	c.277C>T	c.(277-279)CAA>TAA	p.Q93*		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	93	ARM 1; truncated.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			CTAGCAGCTTGAACTGCACTT	0.303													0	0	0	1	0	31	22										A	160253311	G	A	160253311	4	1	18	1	0	0	0	0	0	1	0	0	8432	1299	45	1	1340	1	KPNA4	3	160253311	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11376736	160253311	37769119	129	4703										
FNDC3B	64778	broad.mit.edu	37	chr3	172061902	172061902	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgcatcggaaagtggctgtGaggtctcagagtacagcgtg	15	8	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:172061902G>A	uc003fhy.2	+	19	2276	c.2104G>A	c.(2104-2106)GAG>AAG	p.E702K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E702K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	702	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AAGTGGCTGTGAGGTCTCAGA	0.517													0	0	0	1	0	148	132										A	172061902	G	A	172061902	3	1	18	1	0	0	0	0	1	0	0	0	5970	1291	45	1	2174	1	FNDC3B	3	172061902	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11808591	172061902	25960528	130	4704										
AP2M1	1173	broad.mit.edu	37	chr3	183898646	183898646	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccctcatgtagacaaaagaaGagcagtcacagatcaccagc	8	12	3	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:183898646G>A	uc011bqx.1	+	6	596	c.439G>A	c.(439-441)GAG>AAG	p.E147K	AP2M1_uc003fmw.2_Missense_Mutation_p.E145K|AP2M1_uc003fmx.2_Missense_Mutation_p.E145K|AP2M1_uc003fmy.2_Missense_Mutation_p.E145K|AP2M1_uc011bqy.1_Missense_Mutation_p.E17K|AP2M1_uc011bqz.1_5'UTR	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	147					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GACAAAAGAAGAGCAGTCACA	0.522													0	0	0	1	0	238	250										A	183898646	G	A	183898646	3	1	18	1	0	0	0	0	1	0	0	0	742	943	33	1	454	1	AP2M1	3	183898646	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11836744	183898646	14123784	131	4705										
LEPREL1	55214	broad.mit.edu	37	chr3	189690804	189690804	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttcagtgggactcgaccttCataaccagactgaaaaaaaa	7	10	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:189690804C>T	uc011bsk.1	-	11	1946	c.1558G>A	c.(1558-1560)GAA>AAA	p.E520K	LEPREL1_uc003fsg.2_Missense_Mutation_p.E339K	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	520					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACTCGACCTTCATAACCAGAC	0.398													0	0	0	1	0	40	38										T	189690804	C	T	189690804	3	4	18	1	0	0	0	0	1	0	0	0	8730	835	29	1	588	1	LEPREL1	3	189690804	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5792158	189690804	8331626	132	4706										
RNF168	165918	broad.mit.edu	37	chr3	196199142	196199142	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttttgggtaaagtttatttCtgtttcctcttgatctgggg	10	5	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr3:196199142C>T	uc003fwq.2	-	6	1802	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K	RNF168_uc010iah.2_Missense_Mutation_p.E255K|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	422					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		AAGTTTATTTCTGTTTCCTCT	0.378													0	0	0	1	0	85	102										T	196199142	C	T	196199142	3	4	18	1	0	0	0	0	1	0	0	0	13459	922	32	1	455	1	RNF168	3	196199142	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6508338	196199142	1823288	133	4707										
PIGG	54872	broad.mit.edu	37	chr4	517589	517589	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcagaggccgcgagaagtgGatggtgctggccagtccgtg	17	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:517589G>A	uc003gak.3	+	9	2092	c.1956G>A	c.(1954-1956)TGG>TGA	p.W652*	PIGG_uc003gaj.3_Nonsense_Mutation_p.W644*|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Nonsense_Mutation_p.W519*|PIGG_uc003gal.3_Nonsense_Mutation_p.W563*	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	652					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GCGAGAAGTGGATGGTGCTGG	0.657													0	0	0	1	0	28	15										A	517589	G	A	517589	4	1	18	1	0	0	0	0	0	1	0	0	11888	1183	41	1	1990	1	PIGG	4	517589	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		517589	190636687	134	4708										
WHSC1	7468	broad.mit.edu	37	chr4	1918624	1918624	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaaagagtgcacgccagtatCacgtacagttctttggtgac	10	9	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:1918624C>T	uc003gdz.3	+	4	963	c.787C>T	c.(787-789)CAC>TAC	p.H263Y	WHSC1_uc003geb.3_Missense_Mutation_p.H263Y|WHSC1_uc003gec.3_Missense_Mutation_p.H263Y|WHSC1_uc003ged.3_Missense_Mutation_p.H263Y|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.H263Y|WHSC1_uc003gdy.1_Missense_Mutation_p.H263Y|WHSC1_uc010icd.1_Missense_Mutation_p.H263Y|WHSC1_uc003gea.1_Missense_Mutation_p.H263Y|WHSC1_uc010ice.1_Missense_Mutation_p.H263Y|WHSC1_uc003geh.1_Missense_Mutation_p.H263Y	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	263	PWWP 1.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		ACGCCAGTATCACGTACAGTT	0.383			T	IGH@	MM								0	0	0	1	0	22	27										T	1918624	C	T	1918624	3	4	18	1	0	0	0	0	1	0	0	0	17359	826	29	1	797	1	WHSC1	4	1918624	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1401035	1918624	189235652	135	4709										
HTT	3064	broad.mit.edu	37	chr4	3208581	3208581	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgcttggaggggatccatctCagccagtcgggagctgtgct	15	10	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:3208581C>G	uc011bvq.1	+	45	6097	c.5952C>G	c.(5950-5952)CTC>CTG	p.L1984L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1982					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGATCCATCTCAGCCAGTCGG	0.507													0	0	0	1	0	49	45										G	3208581	C	G	3208581	2	3	18	1	0	0	0	0	0	0	0	1	7457	813	29	1		1	HTT	4	3208581	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1289957	3208581	187945695	136	4710										
RGS12	6002	broad.mit.edu	37	chr4	3432571	3432571	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcatccagacggtggaggatGagcacgtggccgagctgacc	16	11	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:3432571G>C	uc003ggw.2	+	17	4907	c.4003G>C	c.(4003-4005)GAG>CAG	p.E1335Q	RGS12_uc003ggv.2_Missense_Mutation_p.E1335Q|RGS12_uc003ggy.1_3'UTR|RGS12_uc003ggz.2_Missense_Mutation_p.E687Q|RGS12_uc011bvs.1_3'UTR|RGS12_uc003gha.2_Missense_Mutation_p.E677Q|RGS12_uc010icv.2_Missense_Mutation_p.E534Q	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1335						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGTGGAGGATGAGCACGTGGC	0.692													0	0	0	1	0	34	44										C	3432571	G	C	3432571	3	2	18	1	0	0	0	0	1	0	0	0	13295	1291	45	1	4123	1	RGS12	4	3432571	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	223990	3432571	187721705	137	4711										
EVC	2121	broad.mit.edu	37	chr4	5806484	5806484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatggaaaattacaaactgcGgaaaaagcaagaactcagca	9	7	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:5806484G>A	uc003gil.1	+	17	2661	c.2477G>A	c.(2476-2478)CGG>CAG	p.R826Q	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	826					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TACAAACTGCGGAAAAAGCAA	0.557													0	0	0	1	0	55	40										A	5806484	G	A	5806484	3	1	18	1	0	0	0	0	1	0	0	0	5285	1116	39	2	2543	2	EVC	4	5806484	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2373913	5806484	185347792	138	4712										
GRPEL1	80273	broad.mit.edu	37	chr4	7065824	7065824	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgttcctccaacttgaccttCtcttccaggagggtcttctc	7	14	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:7065824C>A	uc003gjy.1	-	2	230	c.189G>T	c.(187-189)GAG>GAT	p.E63D	GRPEL1_uc003gjz.1_Missense_Mutation_p.E63D	NM_025196	NP_079472	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial precursor	63					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding				0						ACTTGACCTTCTCTTCCAGGA	0.552													1	0	4.09171e-25	1	4.31707e-25	57	35										A	7065824	C	A	7065824	3	1	18	1	0	0	0	0	1	0	0	0	6806	912	32	3	476	3	GRPEL1	4	7065824	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1259340	7065824	184088452	139	4713										
SLC2A9	56606	broad.mit.edu	37	chr4	9987351	9987351	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atttcaaaggctcctgcctgGagcgagcaggccatcagcaa	11	12	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:9987351G>A	uc003gmc.2	-	4	538	c.477C>T	c.(475-477)CTC>CTT	p.L159L	SLC2A9_uc003gmd.2_Silent_p.L130L	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	159	Helical; Name=3; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						CTCCTGCCTGGAGCGAGCAGG	0.448													0	0	0	1	0	20	67										A	9987351	G	A	9987351	2	1	18	1	0	0	0	0	0	0	0	1	14552	1161	41	1		1	SLC2A9	4	9987351	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2921527	9987351	181166925	140	4714										
LRRC66	339977	broad.mit.edu	37	chr4	52861441	52861441	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acagagggaagctgttatttCtccggagagggaagggtcta	15	6	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:52861441C>G	uc003gzi.2	-	4	1760	c.1747G>C	c.(1747-1749)GAA>CAA	p.E583Q		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	583						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GCTGTTATTTCTCCGGAGAGG	0.498													0	0	0	1	0	41	93										G	52861441	C	G	52861441	3	3	18	1	0	0	0	0	1	0	0	0	9018	922	32	1	899	1	LRRC66	4	52861441	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	42874090	52861441	138292835	141	4715										
PDGFRA	5156	broad.mit.edu	37	chr4	55161411	55161411	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgacatcggcatagactcttCagacctggtggaagacagct	11	10	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:55161411C>T	uc003han.3	+	23	3573	c.3242C>T	c.(3241-3243)TCA>TTA	p.S1081L	PDGFRA_uc003haa.2_Missense_Mutation_p.S841L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1081	Ser-rich.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ATAGACTCTTCAGACCTGGTG	0.517			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	1	0	33	100										T	55161411	C	T	55161411	3	4	18	1	0	0	0	0	1	0	0	0	11661	838	29	1	3328	1	PDGFRA	4	55161411	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2299970	55161411	135992865	142	4716										
EXOC1	55763	broad.mit.edu	37	chr4	56750054	56750054	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatttctttgaagttgcaaaGatcaagatgactggcacaac	9	7	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:56750054G>C	uc003hbe.1	+	10	1448	c.1290G>C	c.(1288-1290)AAG>AAC	p.K430N	EXOC1_uc003hbf.1_Missense_Mutation_p.K430N|EXOC1_uc003hbg.1_Missense_Mutation_p.K430N	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	430					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AAGTTGCAAAGATCAAGATGA	0.284													0	0	0	1	0	20	21										C	56750054	G	C	56750054	3	2	18	1	0	0	0	0	1	0	0	0	5301	933	33	1	1324	1	EXOC1	4	56750054	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1588643	56750054	134404222	143	4717										
RUFY3	22902	broad.mit.edu	37	chr4	71588434	71588434	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgcgagagctggatgacatCtcacttacacctgacccaga	9	13	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:71588434C>G	uc003hfq.2	+	1	739	c.144C>G	c.(142-144)ATC>ATG	p.I48M	RUFY3_uc003hfp.3_Intron|RUFY3_uc011cax.1_Missense_Mutation_p.I48M|RUFY3_uc003hfr.2_Missense_Mutation_p.I48M	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	48					negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TGGATGACATCTCACTTACAC	0.527													0	0	0	1	0	67	59										G	71588434	C	G	71588434	3	3	18	1	0	0	0	0	1	0	0	0	13740	903	32	1	508	1	RUFY3	4	71588434	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	14838380	71588434	119565842	144	4718										
RUFY3	22902	broad.mit.edu	37	chr4	71634327	71634327	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctggtctgttggtgggtctGaatgtcattgatgccaattt	13	6	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:71634327G>C	uc003hfq.2	+	5	1240	c.645G>C	c.(643-645)CTG>CTC	p.L215L	RUFY3_uc003hfp.3_Silent_p.L275L|RUFY3_uc011cax.1_Silent_p.L233L|RUFY3_uc003hfr.2_Silent_p.L215L|RUFY3_uc011cay.1_Silent_p.L151L	NM_014961	NP_055776	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 2	215	RUN.				negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			TGGTGGGTCTGAATGTCATTG	0.438													0	0	0	1	0	70	69										C	71634327	G	C	71634327	2	2	18	1	0	0	0	0	0	0	0	1	13740	1277	45	1		1	RUFY3	4	71634327	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	45893	71634327	119519949	145	4719										
FRAS1	80144	broad.mit.edu	37	chr4	79400752	79400752	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtttgagattgccttggcaGatgcctctgacaatgcccgc	11	11	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:79400752G>C	uc003hlb.2	+	56	8763	c.8323G>C	c.(8323-8325)GAT>CAT	p.D2775H		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2770	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGCCTTGGCAGATGCCTCTGA	0.527													0	0	0	1	0	28	49										C	79400752	G	C	79400752	3	2	18	1	0	0	0	0	1	0	0	0	6042	942	33	1	8620	1	FRAS1	4	79400752	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7766425	79400752	111753524	146	4720										
HPSE	10855	broad.mit.edu	37	chr4	84223345	84223345	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtatactcgaagcttccttCtctttgaaccttgcacgctt	7	12	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:84223345C>T	uc003hoj.3	-	10	1382	c.1283G>A	c.(1282-1284)AGA>AAA	p.R428K	HPSE_uc010ika.2_Missense_Mutation_p.R370K|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.R171K|HPSE_uc011cct.1_Missense_Mutation_p.R354K|HPSE_uc003hok.3_Missense_Mutation_p.R428K	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	428					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	AAGCTTCCTTCTCTTTGAACC	0.423													0	0	0	1	0	31	61										T	84223345	C	T	84223345	3	4	18	1	0	0	0	0	1	0	0	0	7344	913	32	1	360	1	HPSE	4	84223345	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4822593	84223345	106930931	147	4721										
SPP1	6696	broad.mit.edu	37	chr4	88902684	88902684	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggatgatatggatgatgaaGatgatgatgaccatgtggac	14	3	0	7			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:88902684G>T	uc003hra.2	+	6	439	c.274G>T	c.(274-276)GAT>TAT	p.D92Y	SPP1_uc003hrb.2_Missense_Mutation_p.D65Y|SPP1_uc003hrc.2_Missense_Mutation_p.D78Y|SPP1_uc011cde.1_Missense_Mutation_p.D105Y|SPP1_uc003hrd.2_Missense_Mutation_p.D51Y	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	92					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		GGATGATGAAGATGATGATGA	0.428													1	0	3.41882e-60	1	3.66387e-60	128	91										T	88902684	G	T	88902684	3	4	18	1	0	0	0	0	1	0	0	0	15085	942	33	3	292	3	SPP1	4	88902684	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4679339	88902684	102251592	148	4722										
FAM190A	401145	broad.mit.edu	37	chr4	91230191	91230191	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgctttctgctgatcttacCacagctcagacaccttcaga	6	13	4	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:91230191C>G	uc003hsv.3	+	2	1096	c.756C>G	c.(754-756)ACC>ACG	p.T252T	FAM190A_uc003hsu.3_Silent_p.T252T|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Silent_p.T252T	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	252										large_intestine(1)|ovary(1)	2						CTGATCTTACCACAGCTCAGA	0.438													0	0	0	1	0	32	57										G	91230191	C	G	91230191	2	3	18	1	0	0	0	0	0	0	0	1	5521	581	21	4		4	FAM190A	4	91230191	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2327507	91230191	99924085	149	4723										
PDLIM5	10611	broad.mit.edu	37	chr4	95583676	95583676	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tacacctggcatgacacttgCtttgtatgctcagtaagtag	9	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:95583676C>T	uc003hti.2	+	12	1840	c.1689C>T	c.(1687-1689)TGC>TGT	p.C563C	PDLIM5_uc011cdx.1_Silent_p.C460C|PDLIM5_uc003hth.2_Silent_p.C454C|PDLIM5_uc003htj.2_Silent_p.C238C|PDLIM5_uc003htk.2_Silent_p.C592C|PDLIM5_uc011cdy.1_Silent_p.C441C|PDLIM5_uc003htl.2_Silent_p.C238C	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	563	LIM zinc-binding 3.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		ATGACACTTGCTTTGTATGCT	0.408													0	0	0	1	0	57	27										T	95583676	C	T	95583676	2	4	18	1	0	0	0	0	0	0	0	1	11683	805	28	2		2	PDLIM5	4	95583676	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4353485	95583676	95570600	150	4724										
NHEDC1	150159	broad.mit.edu	37	chr4	103832596	103832596	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttttgtatttacctggtcttCacttggaaaatatcgaacaa	6	7	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:103832596C>T	uc003hww.2	-	8	1050	c.928G>A	c.(928-930)GAA>AAA	p.E310K	NHEDC1_uc003hwu.2_Missense_Mutation_p.E310K|NHEDC1_uc010ilm.2_Missense_Mutation_p.E77K|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_Missense_Mutation_p.E83K	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	310						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		ACCTGGTCTTCACTTGGAAAA	0.299													0	0	0	1	0	17	34										T	103832596	C	T	103832596	3	4	18	1	0	0	0	0	1	0	0	0	10400	835	29	1	739	1	NHEDC1	4	103832596	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	8248920	103832596	87321680	151	4725										
DKK2	27123	broad.mit.edu	37	chr4	107845202	107845202	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcccttcgcacagtcgcaaCgctggaaaatttccagccca	9	15	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:107845202C>T	uc003hyi.2	-	4	1394	c.689G>A	c.(688-690)CGT>CAT	p.R230H	DKK2_uc003hyj.1_3'UTR	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	230	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		ACAGTCGCAACGCTGGAAAAT	0.488													0	0	0	1	0	47	100										T	107845202	C	T	107845202	3	4	18	1	0	0	0	0	1	0	0	0	4545	536	19	2	94	2	DKK2	4	107845202	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4012606	107845202	83309074	152	4726										
SGMS2	166929	broad.mit.edu	37	chr4	108824404	108824404	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcagctcaatggagactctCaggcaaaagttcaacggatt	9	9	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:108824404C>T	uc003hyl.3	+	5	1144	c.589C>T	c.(589-591)CAG>TAG	p.Q197*	uc003hym.1_Intron|SGMS2_uc003hyn.2_Nonsense_Mutation_p.Q197*|SGMS2_uc003hyo.2_Nonsense_Mutation_p.Q197*	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	197					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TGGAGACTCTCAGGCAAAAGT	0.408													0	0	0	1	0	49	133										T	108824404	C	T	108824404	4	4	18	1	0	0	0	0	0	1	0	0	14215	827	29	1	599	1	SGMS2	4	108824404	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	979202	108824404	82329872	153	4727										
NDST4	64579	broad.mit.edu	37	chr4	115750948	115750948	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agattaaaaaattattacctCtggatccataggtggatatt	7	5	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:115750948C>G	uc003ibu.2	-	13	3176	c.2497G>C	c.(2497-2499)GAG>CAG	p.E833Q	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	833	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATTATTACCTCTGGATCCATA	0.343													0	0	0	1	0	32	13										G	115750948	C	G	115750948	3	3	18	1	0	0	0	0	1	0	0	0	10258	922	32	1	129	1	NDST4	4	115750948	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6926544	115750948	75403328	154	4728										
EXOSC9	5393	broad.mit.edu	37	chr4	122737544	122737544	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atgctcccataatactctcaGatagtgaagaagaagaaatg	8	7	1	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:122737544G>C	uc003iea.2	+	11	1285	c.1177G>C	c.(1177-1179)GAT>CAT	p.D393H	EXOSC9_uc003idz.2_Missense_Mutation_p.D410H|EXOSC9_uc003ieb.2_Missense_Mutation_p.D377H	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	393					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						AATACTCTCAGATAGTGAAGA	0.244													0	0	0	1	0	14	36										C	122737544	G	C	122737544	3	2	18	1	0	0	0	0	1	0	0	0	5321	942	33	1	1274	1	EXOSC9	4	122737544	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6986596	122737544	68416732	155	4729										
MFSD8	256471	broad.mit.edu	37	chr4	128878746	128878746	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtctctaaaatgtcccattCtctaggtgtaaagaagaaaa	7	7	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:128878746C>G	uc003ifp.2	-	3	227	c.64G>C	c.(64-66)GAA>CAA	p.E22Q	MFSD8_uc011cgu.1_5'UTR|MFSD8_uc011cgv.1_Missense_Mutation_p.E22Q|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_5'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	22	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						ATGTCCCATTCTCTAGGTGTA	0.308													0	0	0	1	0	59	55										G	128878746	C	G	128878746	3	3	18	1	0	0	0	0	1	0	0	0	9538	927	32	1	1536	1	MFSD8	4	128878746	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6141202	128878746	62275530	156	4730										
GUCY1B3	2983	broad.mit.edu	37	chr4	156726374	156726374	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctatccagaaaaaatacagGaacagaggtatgactaatca	7	7	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:156726374G>C	uc003ipc.2	+	13	1996	c.1829G>C	c.(1828-1830)GGA>GCA	p.G610A	GUCY1B3_uc011cio.1_Missense_Mutation_p.G632A|GUCY1B3_uc011cip.1_Missense_Mutation_p.G590A|GUCY1B3_uc003ipd.2_Missense_Mutation_p.G538A|GUCY1B3_uc010iqf.2_Missense_Mutation_p.G577A|GUCY1B3_uc010iqg.2_Missense_Mutation_p.G581A|GUCY1B3_uc011ciq.1_Missense_Mutation_p.G538A	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	610					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAAAATACAGGAACAGAGGTA	0.358													0	0	0	1	0	11	2										C	156726374	G	C	156726374	3	2	18	1	0	0	0	0	1	0	0	0	6895	1174	41	1	1879	1	GUCY1B3	4	156726374	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	27847628	156726374	34427902	157	4731										
DDX60	55601	broad.mit.edu	37	chr4	169204637	169204637	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcccactaaaatccttctttGacttaatagtttgagtcacg	6	10	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:169204637G>C	uc003irp.2	-	13	1974	c.1682C>G	c.(1681-1683)TCA>TGA	p.S561*		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	561							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		ATCCTTCTTTGACTTAATAGT	0.333													0	0	0	1	0	28	25										C	169204637	G	C	169204637	4	2	18	1	0	0	0	0	0	1	0	0	4378	1294	45	1	3560	1	DDX60	4	169204637	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	12478263	169204637	21949639	158	4732										
SH3RF1	57630	broad.mit.edu	37	chr4	170028027	170028027	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acgacaggtctagactcattCaagacaggacccagggagga	12	10	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr4:170028027C>G	uc003isa.1	-	11	2804	c.2469G>C	c.(2467-2469)TTG>TTC	p.L823F		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	823						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TAGACTCATTCAAGACAGGAC	0.483													0	0	0	1	0	61	54										G	170028027	C	G	170028027	3	3	18	1	0	0	0	0	1	0	0	0	14258	825	29	1	205	1	SH3RF1	4	170028027	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	823390	170028027	21126249	159	4733										
ADCY2	108	broad.mit.edu	37	chr5	7414837	7414837	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatatgccttgttgccatggGatacctgttcatgtgttttg	11	7	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:7414837G>T	uc003jdz.1	+	2	429	c.362G>T	c.(361-363)GGA>GTA	p.G121V		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	121	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GTTGCCATGGGATACCTGTTC	0.428													1	0	8.16721e-17	1	8.45692e-17	33	31										T	7414837	G	T	7414837	3	4	18	1	0	0	0	0	1	0	0	0	294	1174	41	3	368	3	ADCY2	5	7414837	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		7414837	173500423	160	4734										
SEMA5A	9037	broad.mit.edu	37	chr5	9066645	9066645	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgggctttgcatgtgtatcgGaatcgttgctcatagtggcc	13	9	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:9066645G>C	uc003jek.2	-	17	2899	c.2187C>G	c.(2185-2187)TTC>TTG	p.F729L		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	729	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ATGTGTATCGGAATCGTTGCT	0.557													0	0	0	1	0	129	79										C	9066645	G	C	9066645	3	2	18	1	0	0	0	0	1	0	0	0	14037	1165	41	1	1065	1	SEMA5A	5	9066645	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1651808	9066645	171848615	161	4735										
MYO10	4651	broad.mit.edu	37	chr5	16668556	16668556	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gacacccaaccagagttcctGagggaagccaccttccttgc	9	15	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:16668556G>A	uc003jft.3	-	40	6373	c.5905C>T	c.(5905-5907)CAG>TAG	p.Q1969*	MYO10_uc011cnb.1_Nonsense_Mutation_p.Q598*|MYO10_uc011cnc.1_Nonsense_Mutation_p.Q848*|MYO10_uc011cnd.1_Nonsense_Mutation_p.Q1326*|MYO10_uc011cne.1_Nonsense_Mutation_p.Q1326*|MYO10_uc010itx.2_Nonsense_Mutation_p.Q1591*	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1969	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CAGAGTTCCTGAGGGAAGCCA	0.512													0	0	0	1	0	15	9										A	16668556	G	A	16668556	4	1	18	1	0	0	0	0	0	1	0	0	10062	1299	45	1	279	1	MYO10	5	16668556	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7601911	16668556	164246704	162	4736										
OSMR	9180	broad.mit.edu	37	chr5	38884065	38884065	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgttatttggaagggaaacaGattcatggagaacaacttga	11	4	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:38884065G>A	uc003jln.1	+	5	922	c.555G>A	c.(553-555)CAG>CAA	p.Q185Q	OSMR_uc003jlm.1_Silent_p.Q185Q	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	185	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					AAGGGAAACAGATTCATGGAG	0.373													0	0	0	1	0	62	27										A	38884065	G	A	38884065	2	1	18	1	0	0	0	0	0	0	0	1	11292	933	33	1		1	OSMR	5	38884065	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	22215509	38884065	142031195	163	4737										
PAIP1	10605	broad.mit.edu	37	chr5	43543211	43543211	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tataagagaaatttgggataGatgtggccttttaaaaagaa	10	2	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:43543211G>C	uc003job.2	-	4	876	c.629C>G	c.(628-630)TCT>TGT	p.S210C	PAIP1_uc003joa.2_Missense_Mutation_p.S131C|PAIP1_uc010ivp.2_Missense_Mutation_p.S131C|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.S98C	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	210	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATTTGGGATAGATGTGGCCTT	0.358													0	0	0	1	0	22	17										C	43543211	G	C	43543211	3	2	18	1	0	0	0	0	1	0	0	0	11396	942	33	1	842	1	PAIP1	5	43543211	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4659146	43543211	137372049	164	4738										
C5orf35	133383	broad.mit.edu	37	chr5	56207012	56207012	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcaggaccctccgatatgttCcagaggaatccaaagacaaa	8	11	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:56207012C>G	uc003jqx.2	+	2	488	c.115C>G	c.(115-117)CCA>GCA	p.P39A	C5orf35_uc003jqy.2_Intron	NM_153706	NP_714917	Q8NE22	CE035_HUMAN	hypothetical protein LOC133383	39										ovary(1)	1		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.173)		OV - Ovarian serous cystadenocarcinoma(10;2.58e-39)		CCGATATGTTCCAGAGGAATC	0.383													0	0	0	1	0	41	23										G	56207012	C	G	56207012	3	3	18	1	0	0	0	0	1	0	0	0	2294	855	30	1	121	1	C5orf35	5	56207012	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	12663801	56207012	124708248	165	4739										
MAST4	375449	broad.mit.edu	37	chr5	66459046	66459046	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagcagggtccgggcacatcCggcccagcactctccacggt	12	17	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:66459046C>G	uc003jut.1	+	28	3540	c.3472C>G	c.(3472-3474)CGG>GGG	p.R1158G	MAST4_uc003juw.2_Missense_Mutation_p.R1086G|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1350						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CGGGCACATCCGGCCCAGCAC	0.632													0	0	0	1	0	66	255										G	66459046	C	G	66459046	3	3	18	1	0	0	0	0	1	0	0	0	9327	643	23	4	4283	4	MAST4	5	66459046	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10252034	66459046	114456214	166	4740										
BDP1	55814	broad.mit.edu	37	chr5	70855922	70855922	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agagtagaggatctagatctCctgatgcatgcatggacaag	12	7	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:70855922C>T	uc003kbp.1	+	37	7617	c.7354C>T	c.(7354-7356)CCT>TCT	p.P2452S	BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2452					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATCTAGATCTCCTGATGCATG	0.438													0	0	0	1	0	49	34										T	70855922	C	T	70855922	3	4	18	1	0	0	0	0	1	0	0	0	1395	855	30	1	7500	1	BDP1	5	70855922	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4396876	70855922	110059338	167	4741										
TNPO1	3842	broad.mit.edu	37	chr5	72188999	72188999	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgccacagcactgcagtctGgattccttccgtactgtgaa	9	12	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:72188999G>A	uc003kck.3	+	16	1969	c.1822G>A	c.(1822-1824)GGA>AGA	p.G608R	TNPO1_uc011csj.1_Missense_Mutation_p.G558R|TNPO1_uc003kch.2_Missense_Mutation_p.G600R|TNPO1_uc003kci.3_Missense_Mutation_p.G600R|TNPO1_uc003kcg.3_Missense_Mutation_p.G600R	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	608					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		ACTGCAGTCTGGATTCCTTCC	0.398													0	0	0	1	0	46	140										A	72188999	G	A	72188999	3	1	18	1	0	0	0	0	1	0	0	0	16332	1349	47	2	1884	2	TNPO1	5	72188999	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1333077	72188999	108726261	168	4742										
THBS4	7060	broad.mit.edu	37	chr5	79366148	79366148	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtgtggagtcggttgggctgGagatggctatatctgtggaa	18	4	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:79366148G>C	uc003kgh.2	+	12	1690	c.1367G>C	c.(1366-1368)GGA>GCA	p.G456A	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	456	EGF-like 4.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GGTTGGGCTGGAGATGGCTAT	0.562													0	0	0	1	0	15	76										C	79366148	G	C	79366148	3	2	18	1	0	0	0	0	1	0	0	0	15853	1174	41	1	1409	1	THBS4	5	79366148	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7177149	79366148	101549112	169	4743										
MSH3	4437	broad.mit.edu	37	chr5	80150118	80150118	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccattgcctatgctacacttGagtatttcatcagagatgta	7	9	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:80150118G>C	uc003kgz.2	+	21	3236	c.2983G>C	c.(2983-2985)GAG>CAG	p.E995Q		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	995					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		TGCTACACTTGAGTATTTCAT	0.289								MMR					0	0	0	1	0	35	106										C	80150118	G	C	80150118	3	2	18	1	0	0	0	0	1	0	0	0	9871	1291	45	1	3065	1	MSH3	5	80150118	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	783970	80150118	100765142	170	4744										
RASGRF2	5924	broad.mit.edu	37	chr5	80422972	80422972	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acagctgcagcaggacatggGagtccaccaggtgagtaggg	16	9	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:80422972G>C	uc003kha.1	+	17	2676	c.2676G>C	c.(2674-2676)GGG>GGC	p.G892G	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	892					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CAGGACATGGGAGTCCACCAG	0.493													0	0	0	1	0	17	53										C	80422972	G	C	80422972	2	2	18	1	0	0	0	0	0	0	0	1	13073	1161	41	1		1	RASGRF2	5	80422972	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	272854	80422972	100492288	171	4745										
CETN3	1070	broad.mit.edu	37	chr5	89701566	89701566	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgtcataatctttaagaatCttcagtacatcagctttttt	4	8	5	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:89701566C>G	uc003kjo.2	-	3	329	c.204G>C	c.(202-204)AAG>AAC	p.K68N		NM_004365	NP_004356	O15182	CETN3_HUMAN	centrin 3	68	EF-hand 2.				cell division|centrosome cycle|mitosis	centriole	calcium ion binding				0		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		CTTTAAGAATCTTCAGTACAT	0.338													0	0	0	1	0	38	35										G	89701566	C	G	89701566	3	3	18	1	0	0	0	0	1	0	0	0	3276	912	32	1	311	1	CETN3	5	89701566	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	9278594	89701566	91213694	172	4746										
GPR98	84059	broad.mit.edu	37	chr5	89943435	89943435	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggatgggaaggctactgcaaGagagagagatttcattcctg	14	6	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:89943435G>A	uc003kju.2	+	17	3239	c.3143G>A	c.(3142-3144)AGA>AAA	p.R1048K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1048	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCTACTGCAAGAGAGAGAGAT	0.423													0	0	0	1	0	36	92										A	89943435	G	A	89943435	3	1	18	1	0	0	0	0	1	0	0	0	6721	942	33	1	3209	1	GPR98	5	89943435	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	241869	89943435	90971825	173	4747										
FAM170A	340069	broad.mit.edu	37	chr5	118965403	118965403	+	Translation_Start_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagagccaagaagggccaatCtacaggaaaaagtgggaggt	15	6	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:118965403C>G	uc003ksm.2	+	1	150	c.-60C>G	c.(-62--58)ATCTA>ATGTA		FAM170A_uc003ksl.2_Translation_Start_Site|FAM170A_uc003ksn.2_Translation_Start_Site|FAM170A_uc003kso.2_Translation_Start_Site	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A							intracellular	zinc ion binding			skin(1)	1						AAGGGCCAATCTACAGGAAAA	0.398													0	0	0	1	0	25	26										G	118965403	C	G	118965403	1	3	18	1	0	0	0	0	0	0	0	0	5489	928	32	1		1	FAM170A	5	118965403	Translation_Start_Site	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	29021968	118965403	61949857	174	4748										
ZNF608	57507	broad.mit.edu	37	chr5	124079813	124079815	+	In_Frame_Del	DEL	CTC	CTC	-													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcttgattcgcctgtggctCtcctcctcctcctcttcctt							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:124079813_124079815delCTC	uc003ktq.1	-	1	991_993	c.868_870delGAG	c.(868-870)GAGdel	p.E290del	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_In_Frame_Del_p.E290del|ZNF608_uc003ktt.1_In_Frame_Del_p.E290del	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	290	Potential.					intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCTGTGGCTCTCCTCCTCCTCC	0.522																		11	339	---	---								-	124079815	CTC	-	124079813	7	5	18	1	0	1	0	1	0	0	0	0	18031	912	32	0	3704	0	ZNF608	5	124079813	In_Frame_Del	DEL	CTC	TCGA-BT-A3PH-01A-11D-A21Z-08	5114410	124079813	56835447	175	4749										
LMNB1	4001	broad.mit.edu	37	chr5	126147468	126147468	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttgcttcttcttttagcttGagaatgccagactgtcatca	7	9	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:126147468G>C	uc003kud.1	+	5	1185	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	LMNB1_uc003kuc.2_Missense_Mutation_p.E273Q|LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Missense_Mutation_p.E63Q	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	273	Rod.|Coil 2.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		CTTTTAGCTTGAGAATGCCAG	0.423													0	0	0	1	0	30	28										C	126147468	G	C	126147468	3	2	18	1	0	0	0	0	1	0	0	0	8849	1291	45	1	835	1	LMNB1	5	126147468	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2067655	126147468	54767792	176	4750										
AFF4	27125	broad.mit.edu	37	chr5	132270097	132270097	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtacacgggaaggagaatcCcagtttgcatcagggtcccg	14	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:132270097C>A	uc003kyd.2	-	3	1068	c.660G>T	c.(658-660)TGG>TGT	p.W220C	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.W220C|AFF4_uc003kyf.3_Missense_Mutation_p.W220C	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	220	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGGAGAATCCCAGTTTGCAT	0.448													1	0	9.17885e-22	1	9.56911e-22	33	49										A	132270097	C	A	132270097	3	1	18	1	0	0	0	0	1	0	0	0	359	624	22	4	2907	4	AFF4	5	132270097	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6122629	132270097	48645163	177	4751										
PCDHA5	56143	broad.mit.edu	37	chr5	140202695	140202695	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcgtgtctgtggaagtggcCgacgtgaacgacaacgctcc	14	11	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:140202695C>A	uc003lhl.2	+	1	1335	c.1335C>A	c.(1333-1335)GCC>GCA	p.A445A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.A445A|PCDHA5_uc003lhj.1_Silent_p.A445A	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	445	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAGTGGCCGACGTGAACG	0.657													1	0	4.21487e-37	1	4.48562e-37	89	71										A	140202695	C	A	140202695	2	1	18	1	0	0	0	0	0	0	0	1	11527	639	23	4		4	PCDHA5	5	140202695	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7932598	140202695	40712565	178	4752										
PCDHB13	56123	broad.mit.edu	37	chr5	140595757	140595757	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccaggccgacttgctcaccGtctacctggtggtggcgttg	13	14	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:140595757G>A	uc003lja.1	+	1	2249	c.2062G>A	c.(2062-2064)GTC>ATC	p.V688I		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	688	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTGCTCACCGTCTACCTGGT	0.687													0	0	0	1	0	89	168										A	140595757	G	A	140595757	3	1	18	1	0	0	0	0	1	0	0	0	11538	1145	40	2	2064	2	PCDHB13	5	140595757	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	393062	140595757	40319503	179	4753										
FAT2	2196	broad.mit.edu	37	chr5	150934193	150934193	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atgcctaccaccaccctggaGgtggacttcagtgagggttc	12	12	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:150934193G>A	uc003lue.3	-	4	3688	c.3675C>T	c.(3673-3675)ACC>ACT	p.T1225T	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1225	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCACCCTGGAGGTGGACTTCA	0.517													0	0	0	1	0	37	99										A	150934193	G	A	150934193	2	1	18	1	0	0	0	0	0	0	0	1	5690	987	35	2		2	FAT2	5	150934193	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10338436	150934193	29981067	180	4754										
GEMIN5	25929	broad.mit.edu	37	chr5	154267890	154267890	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccaggaaagtgggacctgatGagaagcaggacgaggcagca	16	8	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:154267890G>T	uc003lvx.3	-	28	4490	c.4407C>A	c.(4405-4407)CTC>CTA	p.L1469L	GEMIN5_uc011ddk.1_Silent_p.L1468L	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1469					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GGGACCTGATGAGAAGCAGGA	0.527													1	0	9.16793e-09	1	9.31997e-09	16	59										T	154267890	G	T	154267890	2	4	18	1	0	0	0	0	0	0	0	1	6331	1277	45	3		3	GEMIN5	5	154267890	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3333697	154267890	26647370	181	4755										
ODZ2	57451	broad.mit.edu	37	chr5	167631499	167631499	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccagctgcaacggccttgctGaaggcaacaagctgctggcc	12	14	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:167631499G>A	uc010jjd.2	+	19	3670	c.3670G>A	c.(3670-3672)GAA>AAA	p.E1224K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1001K|ODZ2_uc003lzt.3_Missense_Mutation_p.E597K|ODZ2_uc010jje.2_Missense_Mutation_p.E495K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CGGCCTTGCTGAAGGCAACAA	0.577													0	0	0	1	0	18	42										A	167631499	G	A	167631499	3	1	18	1	0	0	0	0	1	0	0	0	10835	1291	45	1	3744	1	ODZ2	5	167631499	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	13363609	167631499	13283761	182	4756										
DOCK2	1794	broad.mit.edu	37	chr5	169502984	169502984	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagctgggattaagatccatGagaaaagggtgtcagataac	13	5	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:169502984G>A	uc003maf.2	+	47	4842	c.4762G>A	c.(4762-4764)GAG>AAG	p.E1588K	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E1080K|DOCK2_uc003mah.2_Missense_Mutation_p.E144K	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1588	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAAGATCCATGAGAAAAGGGT	0.532													0	0	0	1	0	40	118										A	169502984	G	A	169502984	3	1	18	1	0	0	0	0	1	0	0	0	4687	1291	45	1	4948	1	DOCK2	5	169502984	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1871485	169502984	11412276	183	4757										
NKX2-5	1482	broad.mit.edu	37	chr5	172660109	172660109	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agctcatagacctgcgcctgCgagaagagcacgcgcggctt	13	13	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:172660109C>T	uc003mcm.1	-	2	614	c.438G>A	c.(436-438)TCG>TCA	p.S146S	NKX2-5_uc011dfe.1_3'UTR|NKX2-5_uc010jjt.1_3'UTR	NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	146	Homeobox.				adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCTGCGCCTGCGAGAAGAGCA	0.692													0	0	0	1	0	8	5										T	172660109	C	T	172660109	2	4	18	1	0	0	0	0	0	0	0	1	10453	755	27	2		2	NKX2-5	5	172660109	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3157125	172660109	8255151	184	4758										
CPEB4	80315	broad.mit.edu	37	chr5	173316947	173316947	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctccagctacccataacattCaggatgagatcttggggtca	9	11	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:173316947C>G	uc003mcs.3	+	1	1617	c.211C>G	c.(211-213)CAG>GAG	p.Q71E	CPEB4_uc010jju.1_Missense_Mutation_p.Q71E|CPEB4_uc010jjv.2_Missense_Mutation_p.Q71E|CPEB4_uc011dfg.1_Missense_Mutation_p.Q71E	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	71							nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CCATAACATTCAGGATGAGAT	0.498													0	0	0	1	0	111	83										G	173316947	C	G	173316947	3	3	18	1	0	0	0	0	1	0	0	0	3803	827	29	1	213	1	CPEB4	5	173316947	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	656838	173316947	7598313	185	4759										
CANX	821	broad.mit.edu	37	chr5	179143168	179143168	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgtggtgaatagtggaaatCtgctcaatgacatgactcct	10	8	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr5:179143168C>T	uc003mkk.2	+	8	961	c.784C>T	c.(784-786)CTG>TTG	p.L262L	CANX_uc011dgp.1_Silent_p.L297L|CANX_uc010jlb.1_Silent_p.L198L|CANX_uc003mkl.2_Silent_p.L262L|CANX_uc011dgq.1_Silent_p.L154L	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	262	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGTGGAAATCTGCTCAATGA	0.388													0	0	0	1	0	61	57										T	179143168	C	T	179143168	2	4	18	1	0	0	0	0	0	0	0	1	2618	912	32	1		1	CANX	5	179143168	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5826221	179143168	1772092	186	4760										
HIVEP1	3096	broad.mit.edu	37	chr6	12122571	12122571	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	catgccgaccacaggttattCagcagtacctgcaaatataa	7	11	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12122571C>T	uc003nac.2	+	4	2722	c.2543C>T	c.(2542-2544)TCA>TTA	p.S848L	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	848					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACAGGTTATTCAGCAGTACCT	0.398													0	0	0	1	0	39	107										T	12122571	C	T	12122571	3	4	18	1	0	0	0	0	1	0	0	0	7186	838	29	1	2553	1	HIVEP1	6	12122571	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		12122571	158992496	187	4761			2	15		6	5	1064	N	C	4.615993e-09
HIVEP1	3096	broad.mit.edu	37	chr6	12122603	12122603	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caaatataatacctcctcctCatccactaagaggaagtcag	5	12	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12122603C>T	uc003nac.2	+	4	2754	c.2575C>T	c.(2575-2577)CAT>TAT	p.H859Y	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	859					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACCTCCTCCTCATCCACTAAG	0.443													0	0	0	1	0	36	91										T	12122603	C	T	12122603	3	4	18	1	0	0	0	0	1	0	0	0	7186	826	29	1	2585	1	HIVEP1	6	12122603	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	32	12122603	158992464	188	4762			2	15		6	5	1064	N	C	4.615993e-09
HIVEP1	3096	broad.mit.edu	37	chr6	12122781	12122781	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgttcttggtactggacagtCcctggatgagagccaccaag	12	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12122781C>G	uc003nac.2	+	4	2932	c.2753C>G	c.(2752-2754)TCC>TGC	p.S918C	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	918					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				ACTGGACAGTCCCTGGATGAG	0.517													0	0	0	1	0	10	33										G	12122781	C	G	12122781	3	3	18	1	0	0	0	0	1	0	0	0	7186	855	30	1	2763	1	HIVEP1	6	12122781	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	178	12122781	158992286	189	4763			2	15		6	5	1064	N	C	4.615993e-09
HIVEP1	3096	broad.mit.edu	37	chr6	12123600	12123600	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcacccttctcgggacgggtCtcatcctcaccagcttgcac	8	17	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12123600C>T	uc003nac.2	+	4	3751	c.3572C>T	c.(3571-3573)TCT>TTT	p.S1191F	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1191					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CGGGACGGGTCTCATCCTCAC	0.512													0	0	0	1	0	3	30										T	12123600	C	T	12123600	3	4	18	1	0	0	0	0	1	0	0	0	7186	913	32	1	3582	1	HIVEP1	6	12123600	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	819	12123600	158991467	190	4764			2	15		6	5	1064	N	C	4.615993e-09
HIVEP1	3096	broad.mit.edu	37	chr6	12123624	12123624	+	Nonsense_Mutation	SNP	C	C	G													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcctcaccagcttgcactatCagacgctctcagaggagaac							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12123624C>G	uc003nac.2	+	4	3775	c.3596C>G	c.(3595-3597)TCA>TGA	p.S1199*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1199					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTTGCACTATCAGACGCTCTC	0.512													0	0	0	1	0	4	31										G	12123624	C	G	12123624	4	3	18	1	0	0	0	0	0	1	0	0	7186	838	29	1	3606	1	HIVEP1	6	12123624	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	24	12123624	158991443	191	4765	23	2	2	15		6	5	1064	N	C	4.615993e-09
HIVEP1	3096	broad.mit.edu	37	chr6	12123634	12123634	+	Silent	SNP	C	C	T													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttgcactatcagacgctctCagaggagaacttcaggaaag							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:12123634C>T	uc003nac.2	+	4	3785	c.3606C>T	c.(3604-3606)CTC>CTT	p.L1202L	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1202					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CAGACGCTCTCAGAGGAGAAC	0.517													0	0	0	1	0	3	34										T	12123634	C	T	12123634	2	4	18	1	0	0	0	0	0	0	0	1	7186	813	29	1		1	HIVEP1	6	12123634	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10	12123634	158991433	192	4766	23	2	2	15		6	5	1064	N	C	4.615993e-09
RNF182	221687	broad.mit.edu	37	chr6	13977385	13977385	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcctgaagacactgcggagtCtcaggcctctgatgagctgg	13	11	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:13977385C>G	uc003nbe.2	+	3	453	c.35C>G	c.(34-36)TCT>TGT	p.S12C	RNF182_uc003nbf.2_Missense_Mutation_p.S12C|RNF182_uc003nbg.2_Missense_Mutation_p.S12C	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	12						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			ACTGCGGAGTCTCAGGCCTCT	0.468													0	0	0	1	0	45	100										G	13977385	C	G	13977385	3	3	18	1	0	0	0	0	1	0	0	0	13466	913	32	1	37	1	RNF182	6	13977385	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1853751	13977385	157137682	193	4767										
KIF13A	63971	broad.mit.edu	37	chr6	17771434	17771434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcagccagggttatgtgcctGaggtggaggcatgctctgca	16	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:17771434G>C	uc003ncg.3	-	38	4597	c.4492C>G	c.(4492-4494)CAG>GAG	p.Q1498E	KIF13A_uc003ncf.2_Intron|KIF13A_uc003nch.3_Intron|KIF13A_uc003nci.3_Intron|KIF13A_uc003nce.1_Intron	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1498					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTATGTGCCTGAGGTGGAGGC	0.458													0	0	0	1	0	8	17										C	17771434	G	C	17771434	3	2	18	1	0	0	0	0	1	0	0	0	8274	1299	45	1	958	1	KIF13A	6	17771434	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3794049	17771434	153343633	194	4768										
LRRC16A	55604	broad.mit.edu	37	chr6	25619782	25619782	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatctaatgactccggggaaGaagcagaaaaagagtttatt	10	5	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:25619782G>A	uc011djw.1	+	37	4463	c.4087G>A	c.(4087-4089)GAA>AAA	p.E1363K	LRRC16A_uc010jpx.2_Missense_Mutation_p.E1318K|LRRC16A_uc010jpy.2_Missense_Mutation_p.E1357K	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1363					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CTCCGGGGAAGAAGCAGAAAA	0.498													0	0	0	1	0	62	45										A	25619782	G	A	25619782	3	1	18	1	0	0	0	0	1	0	0	0	8971	943	33	1	4233	1	LRRC16A	6	25619782	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7848348	25619782	145495285	195	4769										
ZNF322A	79692	broad.mit.edu	37	chr6	26637743	26637743	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtatttatagtgtagctcctCtgtttgagttctcattttct	7	7	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:26637743C>G	uc003nil.3	-	4	1668	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	ZNF322A_uc003nij.2_5'Flank	NM_024639	NP_078915	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322A	347					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0						TGTAGCTCCTCTGTTTGAGTT	0.428													0	0	0	1	0	63	101										G	26637743	C	G	26637743	3	3	18	1	0	0	0	0	1	0	0	0	17838	922	32	1	173	1	ZNF322A	6	26637743	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1017961	26637743	144477324	196	4770										
FKSG83	83954	broad.mit.edu	37	chr6	27293278	27293278	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcatcaaaagacggtctttCatattcacagtatcagtctg	8	9	6	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:27293278C>G	uc010jqt.2	+	1	701	c.217C>G	c.(217-219)CAT>GAT	p.H73D	FKSG83_uc010jqs.1_3'UTR	NM_032030	NP_114419	Q3KNW7	Q3KNW7_HUMAN	FKSG83	73						integral to membrane	pheromone receptor activity				0						GACGGTCTTTCATATTCACAG	0.398													0	0	0	1	0	72	67										G	27293278	C	G	27293278	3	3	18	1	0	0	0	0	1	0	0	0	5918	826	29	1	219	1	FKSG83	6	27293278	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	655535	27293278	143821789	197	4771										
GNL1	2794	broad.mit.edu	37	chr6	30514513	30514513	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggggatgaaaacacaggctGaggcggccgtccactgccag	16	11	0	2	rs5875262		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:30514513G>A	uc003nqh.2	-	11	2570	c.1542C>T	c.(1540-1542)CTC>CTT	p.L514L	GNL1_uc011dmi.1_Silent_p.L311L|GNL1_uc011dmj.1_Silent_p.L512L|GNL1_uc011dmk.1_Silent_p.L169L	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	514				L -> V (in Ref. 1; AAA66492).	response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						AACACAGGCTGAGGCGGCCGT	0.507													0	0	0	1	0	28	83										A	30514513	G	A	30514513	2	1	18	1	0	0	0	0	0	0	0	1	6535	1277	45	1		1	GNL1	6	30514513	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3221235	30514513	140600554	198	4772										
MDC1	9656	broad.mit.edu	37	chr6	30672146	30672146	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctggctcaggggtcttgacaGaggacctatttgtcctgcac	12	11	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:30672146G>C	uc003nrg.3	-	10	5254	c.4814C>G	c.(4813-4815)TCT>TGT	p.S1605C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S1212C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1605	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GGTCTTGACAGAGGACCTATT	0.602								Other_conserved_DNA_damage_response_genes					0	0	0	1	0	91	86										C	30672146	G	C	30672146	3	2	18	1	0	0	0	0	1	0	0	0	9403	942	33	1	1479	1	MDC1	6	30672146	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	157633	30672146	140442921	199	4773										
MDC1	9656	broad.mit.edu	37	chr6	30673848	30673848	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcaggtactgtaggaggcaGacaagcatctggagattcct	12	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:30673848G>C	uc003nrg.3	-	10	3552	c.3112C>G	c.(3112-3114)CTG>GTG	p.L1038V	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.L645V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1038	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GTAGGAGGCAGACAAGCATCT	0.517								Other_conserved_DNA_damage_response_genes					0	0	0	1	0	41	35										C	30673848	G	C	30673848	3	2	18	1	0	0	0	0	1	0	0	0	9403	933	33	1	3181	1	MDC1	6	30673848	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1702	30673848	140441219	200	4774										
BAT5	7920	broad.mit.edu	37	chr6	31660894	31660894	+	Frame_Shift_Del	DEL	C	C	-													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgggcgaagcagggccacaCcccggcgggaagggccccct							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:31660894delC	uc003nvy.1	-	7	566	c.536delG	c.(535-537)GGTfs	p.G179fs	BAT5_uc003nvx.1_5'UTR|BAT5_uc011dny.1_Frame_Shift_Del_p.G146fs|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_5'UTR|BAT5_uc010jtc.1_RNA|BAT5_uc011doa.1_Frame_Shift_Del_p.V81fs	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	179						integral to membrane	hydrolase activity|protein binding				0						CAGGGCCACACCCCGGCGGGA	0.622																		24	66	---	---								-	31660894	C	-	31660894	7	5	18	1	0	1	0	1	0	0	0	0	1324	507	18	0	1196	0	BAT5	6	31660894	Frame_Shift_Del	DEL	C	TCGA-BT-A3PH-01A-11D-A21Z-08	987046	31660894	139454173	201	4775										
BAT5	7920	broad.mit.edu	37	chr6	31669889	31669889	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcatgtttctccagggcacGgggctgatagtacgtatcct	12	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:31669889G>A	uc003nvy.1	-	2	181	c.151C>T	c.(151-153)CGT>TGT	p.R51C	BAT5_uc003nvx.1_5'UTR|BAT5_uc011dny.1_Intron|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_5'UTR|BAT5_uc010jtc.1_Intron|BAT5_uc011doa.1_5'UTR	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	51						integral to membrane	hydrolase activity|protein binding				0						TCCAGGGCACGGGGCTGATAG	0.547													0	0	0	1	0	19	54										A	31669889	G	A	31669889	3	1	18	1	0	0	0	0	1	0	0	0	1324	1116	39	2	1601	2	BAT5	6	31669889	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	8995	31669889	139445178	202	4776										
TNXB	7148	broad.mit.edu	37	chr6	32046817	32046817	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcccctcactcacctgtcacGcccacggcggacaccgggcc	10	21	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:32046817G>A	uc003nzl.2	-	11	4570	c.4368C>T	c.(4366-4368)GGC>GGT	p.G1456G		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1543					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CACCTGTCACGCCCACGGCGG	0.662													0	0	0	1	0	47	27										A	32046817	G	A	32046817	2	1	18	1	0	0	0	0	0	0	0	1	16343	1074	38	2		2	TNXB	6	32046817	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	376928	32046817	139068250	203	4777										
HLA-DOA	3111	broad.mit.edu	37	chr6	32977305	32977305	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccaggaccagccctgctctGagggccattacactctggtg	11	15	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:32977305G>C	uc003ocr.2	-	1	85	c.9C>G	c.(7-9)CTC>CTG	p.L3L	HLA-DOA_uc010juj.2_5'UTR|HLA-DOA_uc010jui.2_Silent_p.L3L	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	3					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GCCCTGCTCTGAGGGCCATTA	0.587													0	0	0	1	0	5	12										C	32977305	G	C	32977305	2	2	18	1	0	0	0	0	0	0	0	1	7200	1277	45	1		1	HLA-DOA	6	32977305	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	930488	32977305	138137762	204	4778										
ANKS1A	23294	broad.mit.edu	37	chr6	34985275	34985275	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggcggagcagcagcagccgGagccaggactctgcggaggg	19	11	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:34985275G>C	uc003ojx.3	+	11	1591	c.1449G>C	c.(1447-1449)CGG>CGC	p.R483R	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Silent_p.R23R|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	483						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						GCAGCAGCCGGAGCCAGGACT	0.592													0	0	0	1	0	70	54										C	34985275	G	C	34985275	2	2	18	1	0	0	0	0	0	0	0	1	688	1161	41	1		1	ANKS1A	6	34985275	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2007970	34985275	136129792	205	4779										
MAPK14	1432	broad.mit.edu	37	chr6	36020527	36020527	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtggcagtgaagaagctctcCagaccatttcagtccatcat	9	11	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:36020527C>T	uc003olp.2	+	2	649	c.168C>T	c.(166-168)TCC>TCT	p.S56S	MAPK14_uc011dth.1_Silent_p.S56S|MAPK14_uc003olo.2_Silent_p.S56S|MAPK14_uc003olq.2_Silent_p.S56S|MAPK14_uc003olr.2_Silent_p.S56S|MAPK14_uc011dti.1_5'UTR	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1	56	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						AGAAGCTCTCCAGACCATTTC	0.383													0	0	0	1	0	32	93										T	36020527	C	T	36020527	2	4	18	1	0	0	0	0	0	0	0	1	9276	581	21	2		2	MAPK14	6	36020527	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1035252	36020527	135094540	206	4780										
PPIL1	51645	broad.mit.edu	37	chr6	36823787	36823787	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttggtatctggccccgcattGgccattgcgagaattccagc	11	12	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:36823787G>A	uc003omu.2	-	4	555	c.303C>T	c.(301-303)GCC>GCT	p.A101A		NM_016059	NP_057143	Q9Y3C6	PPIL1_HUMAN	peptidylprolyl isomerase-like 1	101	PPIase cyclophilin-type.|Cyclosporin A binding.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GCCCCGCATTGGCCATTGCGA	0.552													0	0	0	1	0	23	23										A	36823787	G	A	36823787	2	1	18	1	0	0	0	0	0	0	0	1	12326	1335	47	2		2	PPIL1	6	36823787	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	803260	36823787	134291280	207	4781										
LRFN2	57497	broad.mit.edu	37	chr6	40399707	40399707	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtgcggctggtgctgttgctGaggtgtggcagctggacgat	19	7	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:40399707G>C	uc003oph.1	-	2	1611	c.1146C>G	c.(1144-1146)CTC>CTG	p.L382L		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	382	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCTGTTGCTGAGGTGTGGCA	0.652													0	0	0	1	0	23	50										C	40399707	G	C	40399707	2	2	18	1	0	0	0	0	0	0	0	1	8938	1277	45	1		1	LRFN2	6	40399707	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3575920	40399707	130715360	208	4782										
PRPH2	5961	broad.mit.edu	37	chr6	42689881	42689881	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatagcacccccatccctatCaatgagttgggcacaaaatg	8	12	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:42689881C>G	uc003osk.2	-	1	478	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	64	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CCATCCCTATCAATGAGTTGG	0.517													0	0	0	1	0	78	70										G	42689881	C	G	42689881	3	3	18	1	0	0	0	0	1	0	0	0	12577	825	29	1	860	1	PRPH2	6	42689881	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2290174	42689881	128425186	209	4783										
ME1	4199	broad.mit.edu	37	chr6	84108173	84108173	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcatgaatttctcaatgtcaGatgtcagcactctataaaag	7	8	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:84108173G>C	uc003pjy.2	-	3	381	c.275C>G	c.(274-276)TCT>TGT	p.S92C	ME1_uc011dzb.1_Missense_Mutation_p.S17C|ME1_uc011dzc.1_Intron	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	92					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	CTCAATGTCAGATGTCAGCAC	0.363													0	0	0	1	0	14	54										C	84108173	G	C	84108173	3	2	18	1	0	0	0	0	1	0	0	0	9417	942	33	1	1491	1	ME1	6	84108173	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	41418292	84108173	87006894	210	4784										
MDN1	23195	broad.mit.edu	37	chr6	90425454	90425454	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtgaggacacctccgggttCaagcaaagcattcaaacgat	10	10	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:90425454C>G	uc003pnn.1	-	45	6894	c.6778G>C	c.(6778-6780)GAA>CAA	p.E2260Q		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2260					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCTCCGGGTTCAAGCAAAGCA	0.448													0	0	0	1	0	28	107										G	90425454	C	G	90425454	3	3	18	1	0	0	0	0	1	0	0	0	9415	835	29	1	10244	1	MDN1	6	90425454	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6317281	90425454	80689613	211	4785										
PREP	5550	broad.mit.edu	37	chr6	105825294	105825294	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgaagtggcaactatacttgGgataatcatatagttcagtc	9	6	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:105825294G>A	uc003prc.2	-	3	424	c.221C>T	c.(220-222)CCC>CTC	p.P74L		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	74					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ACTATACTTGGGATAATCATA	0.358													0	0	0	1	0	29	106										A	105825294	G	A	105825294	3	1	18	1	0	0	0	0	1	0	0	0	12474	1232	43	2	1963	2	PREP	6	105825294	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	15399840	105825294	65289773	212	4786										
MARCKS	4082	broad.mit.edu	37	chr6	114181750	114181750	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccccccagcggaggcggcaGagtaaaagagcaagcttttg	13	12	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:114181750G>C	uc003pvy.3	+	2	1389	c.994G>C	c.(994-996)GAG>CAG	p.E332Q		NM_002356	NP_002347	P29966	MARCS_HUMAN	myristoylated alanine-rich protein kinase C	332					energy reserve metabolic process|regulation of insulin secretion	actin cytoskeleton|plasma membrane	actin filament binding|calmodulin binding				0		all_cancers(87;7.65e-05)|all_epithelial(87;0.000296)|all_hematologic(75;0.0172)|Colorectal(196;0.0317)|all_lung(197;0.198)		Epithelial(106;1.59e-07)|all cancers(137;9.85e-07)|OV - Ovarian serous cystadenocarcinoma(136;0.000322)		GGAGGCGGCAGAGTAAAAGAG	0.597													0	0	0	1	0	73	53										C	114181750	G	C	114181750	3	2	18	1	0	0	0	0	1	0	0	0	9309	943	33	1	1000	1	MARCKS	6	114181750	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	8356456	114181750	56933317	213	4787										
PLN	5350	broad.mit.edu	37	chr6	118880088	118880088	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cctgtcctgctggtatcatgGagaaagtccaatacctcact	8	12	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:118880088G>C	uc003pye.2	+	2	215	c.4G>C	c.(4-6)GAG>CAG	p.E2Q	C6orf204_uc003pxz.1_Intron|C6orf204_uc003pya.1_Intron|C6orf204_uc003pyb.2_Intron|C6orf204_uc011ebj.1_Intron|C6orf204_uc003pyc.2_Intron	NM_002667	NP_002658	P26678	PPLA_HUMAN	phospholamban	2	Cytoplasmic (Potential).				blood circulation|regulation of calcium ion transport	integral to membrane|mitochondrial membrane|sarcoplasmic reticulum	calcium channel regulator activity|protein binding				0		all_cancers(87;0.0916)|all_epithelial(87;0.131)		GBM - Glioblastoma multiforme(226;0.0325)|all cancers(137;0.154)|OV - Ovarian serous cystadenocarcinoma(136;0.176)		TGGTATCATGGAGAAAGTCCA	0.403													0	0	0	1	0	17	17										C	118880088	G	C	118880088	3	2	18	1	0	0	0	0	1	0	0	0	12100	1175	41	1	6	1	PLN	6	118880088	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4698338	118880088	52234979	214	4788										
PTPRK	5796	broad.mit.edu	37	chr6	128318060	128318060	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acttacatgctataatgtttCcatatcggttttttgctcta	5	8	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:128318060C>A	uc003qbk.2	-	17	3117	c.2750G>T	c.(2749-2751)GGA>GTA	p.G917V	PTPRK_uc003qbj.2_Missense_Mutation_p.G918V|PTPRK_uc010kfc.2_Missense_Mutation_p.G918V|PTPRK_uc011ebu.1_Missense_Mutation_p.G934V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	917	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TATAATGTTTCCATATCGGTT	0.333													1	0	0.0135373	1	0.0135816	9	19										A	128318060	C	A	128318060	3	1	18	1	0	0	0	0	1	0	0	0	12805	855	30	3	1647	3	PTPRK	6	128318060	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	9437972	128318060	42797007	215	4789										
HIVEP2	3097	broad.mit.edu	37	chr6	143095470	143095470	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggaaaaggaaataagtcctCagaggcaacggatggcaaag	13	6	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:143095470C>T	uc003qjd.2	-	5	1149	c.406G>A	c.(406-408)GAG>AAG	p.E136K		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AATAAGTCCTCAGAGGCAACG	0.502													0	0	0	1	0	77	71										T	143095470	C	T	143095470	3	4	18	1	0	0	0	0	1	0	0	0	7187	835	29	1	6958	1	HIVEP2	6	143095470	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	14777410	143095470	28019597	216	4790										
UTRN	7402	broad.mit.edu	37	chr6	145051568	145051568	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggcccgagttttcttggctGatcagccaattgaggcccct	11	12	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:145051568G>A	uc003qkt.2	+	53	7977	c.7885G>A	c.(7885-7887)GAT>AAT	p.D2629N		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2629	Spectrin 18.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TTTCTTGGCTGATCAGCCAAT	0.448													0	0	0	1	0	19	39										A	145051568	G	A	145051568	3	1	18	1	0	0	0	0	1	0	0	0	17100	1290	45	1	8095	1	UTRN	6	145051568	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1956098	145051568	26063499	217	4791										
RAET1E	135250	broad.mit.edu	37	chr6	150210659	150210659	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtcatgttcattgcgtcaaaGaggagggatttctctccatt	10	8	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:150210659G>C	uc003qnl.1	-	3	507	c.447C>G	c.(445-447)CTC>CTG	p.L149L	uc003qni.1_Intron|RAET1E_uc003qnj.2_Silent_p.L149L|RAET1E_uc003qnk.1_Silent_p.L113L|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	149	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TTGCGTCAAAGAGGAGGGATT	0.468													0	0	0	1	0	84	69										C	150210659	G	C	150210659	2	2	18	1	0	0	0	0	0	0	0	1	12999	929	33	1		1	RAET1E	6	150210659	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	5159091	150210659	20904408	218	4792										
ARID1B	57492	broad.mit.edu	37	chr6	157256700	157256700	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatacagcaagaaagaccatCaagtttaccagtaagacatt	6	8	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr6:157256700C>G	uc003qqn.2	+	4	1966	c.1814C>G	c.(1813-1815)TCA>TGA	p.S605*	ARID1B_uc003qqo.2_Nonsense_Mutation_p.S618*|ARID1B_uc003qqp.2_Nonsense_Mutation_p.S605*|ARID1B_uc003qqq.1_Nonsense_Mutation_p.S33*	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	663					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GAAAGACCATCAAGTTTACCA	0.373													0	0	0	1	0	17	58										G	157256700	C	G	157256700	4	3	18	1	0	0	0	0	0	1	0	0	914	838	29	1	2045	1	ARID1B	6	157256700	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7046041	157256700	13858367	219	4793										
SUN1	23353	broad.mit.edu	37	chr7	872165	872165	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtttgaagtggtgaacatgGatttttctcggcttcacatg	12	6	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:872165G>C	uc011jvp.1	+	2	83	c.4G>C	c.(4-6)GAT>CAT	p.D2H	SUN1_uc010ksa.1_Missense_Mutation_p.D23H|SUN1_uc003sje.1_Missense_Mutation_p.D2H|SUN1_uc003sjf.2_Intron|SUN1_uc011jvq.1_Missense_Mutation_p.D2H	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	2	Nuclear.|LMNA-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GGTGAACATGGATTTTTCTCG	0.537													0	0	0	1	0	12	17										C	872165	G	C	872165	3	2	18	1	0	0	0	0	1	0	0	0	15388	1174	41	1	73	1	SUN1	7	872165	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		872165	158266498	220	4794										
SUN1	23353	broad.mit.edu	37	chr7	872210	872210	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtcctccccagtgtgtgccgGagaacacgggctacacgtat	12	13	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:872210G>C	uc011jvp.1	+	2	128	c.49G>C	c.(49-51)GAG>CAG	p.E17Q	SUN1_uc010ksa.1_Missense_Mutation_p.E38Q|SUN1_uc003sje.1_Missense_Mutation_p.E17Q|SUN1_uc003sjf.2_Intron|SUN1_uc011jvq.1_Missense_Mutation_p.E17Q	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	17	Nuclear.|LMNA-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GTGTGTGCCGGAGAACACGGG	0.562													0	0	0	1	0	9	16										C	872210	G	C	872210	3	2	18	1	0	0	0	0	1	0	0	0	15388	1175	41	1	118	1	SUN1	7	872210	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	45	872210	158266453	221	4795										
HDAC9	9734	broad.mit.edu	37	chr7	18767220	18767220	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagcctttcctggaacccacGcacacacgtgcgctctctgt	8	17	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:18767220G>A	uc003suh.2	+	12	1781	c.1740G>A	c.(1738-1740)ACG>ACA	p.T580T	HDAC9_uc003sue.2_Silent_p.T580T|HDAC9_uc011jyd.1_Silent_p.T580T|HDAC9_uc003sui.2_Silent_p.T583T|HDAC9_uc003suj.2_Silent_p.T539T|HDAC9_uc003sua.1_Silent_p.T558T|HDAC9_uc010kue.1_Silent_p.T235T	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	580					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGAACCCACGCACACACGTG	0.527													0	0	0	1	0	4	14										A	18767220	G	A	18767220	2	1	18	1	0	0	0	0	0	0	0	1	7014	1074	38	2		2	HDAC9	7	18767220	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	17895010	18767220	140371443	222	4796										
ABCB5	340273	broad.mit.edu	37	chr7	20766683	20766683	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atagcaactgaagctttggaGaatatacgtactatagtgtc	9	6	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:20766683G>C	uc003suw.3	+	13	1857	c.1311G>C	c.(1309-1311)GAG>GAC	p.E437D	ABCB5_uc010kuh.2_Missense_Mutation_p.E882D|ABCB5_uc003sux.1_Missense_Mutation_p.E60D	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	437	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AAGCTTTGGAGAATATACGTA	0.328													0	0	0	1	0	33	48										C	20766683	G	C	20766683	3	2	18	1	0	0	0	0	1	0	0	0	44	933	33	1	2769	1	ABCB5	7	20766683	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1999463	20766683	138371980	223	4797										
STK31	56164	broad.mit.edu	37	chr7	23821065	23821065	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atcctgatggctctcaaattGagaaaataaaagaagaaata	7	5	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:23821065G>C	uc003sws.3	+	16	2060	c.1993G>C	c.(1993-1995)GAG>CAG	p.E665Q	STK31_uc003swt.3_Missense_Mutation_p.E642Q|STK31_uc011jze.1_Missense_Mutation_p.E665Q|STK31_uc010kuq.2_Missense_Mutation_p.E642Q	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	665							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CTCTCAAATTGAGAAAATAAA	0.299													0	0	0	1	0	20	43										C	23821065	G	C	23821065	3	2	18	1	0	0	0	0	1	0	0	0	15295	1291	45	1	2055	1	STK31	7	23821065	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3054382	23821065	135317598	224	4798										
VPS41	27072	broad.mit.edu	37	chr7	38860835	38860835	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtcaaaagtctcgtgaaattCttctccagaatacagtccaa	6	10	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:38860835C>G	uc003tgy.2	-	6	378	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	VPS41_uc003tgz.2_Missense_Mutation_p.E93Q|VPS41_uc010kxn.2_Missense_Mutation_p.E118Q	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	118					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TCGTGAAATTCTTCTCCAGAA	0.368													0	0	0	1	0	75	102										G	38860835	C	G	38860835	3	3	18	1	0	0	0	0	1	0	0	0	17207	922	32	1	2308	1	VPS41	7	38860835	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	15039770	38860835	120277828	225	4799										
POLM	27434	broad.mit.edu	37	chr7	44119193	44119193	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gacaaccctagaggagtgttCtccaaagtggggaagcccct	12	11	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:44119193C>G	uc003tjt.2	-	4	711	c.619G>C	c.(619-621)GAA>CAA	p.E207Q	POLM_uc003tjw.1_5'Flank|POLM_uc003tju.2_Missense_Mutation_p.E207Q|POLM_uc003tjx.2_Missense_Mutation_p.E207Q|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Intron|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Missense_Mutation_p.E207Q|POLM_uc011kbu.1_Missense_Mutation_p.E174Q|POLM_uc010kxy.2_Missense_Mutation_p.E207Q	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	207					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						GAGGAGTGTTCTCCAAAGTGG	0.637								DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	42	67										G	44119193	C	G	44119193	3	3	18	1	0	0	0	0	1	0	0	0	12206	922	32	1	897	1	POLM	7	44119193	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5258358	44119193	115019470	226	4800										
CCM2	83605	broad.mit.edu	37	chr7	45115443	45115443	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcctggagaccattggcgtGaaggatggccgcggcatcat	14	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:45115443G>A	uc003tmo.2	+	10	1268	c.1122G>A	c.(1120-1122)GTG>GTA	p.V374V	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Silent_p.V316V|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Silent_p.V283V|CCM2_uc003tms.2_Silent_p.V395V	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	374					endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						CCATTGGCGTGAAGGATGGCC	0.612									Familial_Cerebral_Cavernous_Angioma				0	0	0	1	0	54	59										A	45115443	G	A	45115443	2	1	18	1	0	0	0	0	0	0	0	1	2908	1277	45	1		1	CCM2	7	45115443	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	996250	45115443	114023220	227	4801										
CLIP2	7461	broad.mit.edu	37	chr7	73790516	73790516	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcacaggaggtggcgggcctGaaggacaaggttcagcaggc	18	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:73790516G>A	uc003uam.2	+	10	2112	c.1785G>A	c.(1783-1785)CTG>CTA	p.L595L	CLIP2_uc003uan.2_Silent_p.L560L|CLIP2_uc003uao.2_5'UTR	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	595	Potential.					microtubule associated complex				skin(3)	3						TGGCGGGCCTGAAGGACAAGG	0.612													0	0	0	1	0	26	26										A	73790516	G	A	73790516	2	1	18	1	0	0	0	0	0	0	0	1	3533	1277	45	1		1	CLIP2	7	73790516	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	28675073	73790516	85348147	228	4802										
AKAP9	10142	broad.mit.edu	37	chr7	91709233	91709233	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	taaatcaactaagagaagatGagttggggtcagatatatca	10	4	3	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:91709233G>A	uc003ulg.2	+	31	8011	c.7786G>A	c.(7786-7788)GAG>AAG	p.E2596K	AKAP9_uc003ulf.2_Missense_Mutation_p.E2588K|AKAP9_uc003uli.2_Missense_Mutation_p.E2219K|AKAP9_uc003ulj.2_Missense_Mutation_p.E366K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2608	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAGAGAAGATGAGTTGGGGTC	0.318			T	BRAF	papillary thyroid								0	0	0	1	0	50	39										A	91709233	G	A	91709233	3	1	18	1	0	0	0	0	1	0	0	0	459	1291	45	1	7908	1	AKAP9	7	91709233	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	17918717	91709233	67429430	229	4803										
HEPACAM2	253012	broad.mit.edu	37	chr7	92838029	92838029	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagcgaggcccatgcttaatGatatatgtagtattgtcagt	10	6	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:92838029G>A	uc003umm.2	-	4	899	c.876C>T	c.(874-876)ATC>ATT	p.I292I	HEPACAM2_uc003uml.2_Silent_p.I280I|HEPACAM2_uc010lff.2_Silent_p.I280I|HEPACAM2_uc011khy.1_Silent_p.I315I	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	292	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CATGCTTAATGATATATGTAG	0.463													0	0	0	1	0	37	59										A	92838029	G	A	92838029	2	1	18	1	0	0	0	0	0	0	0	1	7053	1280	45	1		1	HEPACAM2	7	92838029	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1128796	92838029	66300634	230	4804										
CCDC132	55610	broad.mit.edu	37	chr7	92921129	92921129	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atgaaaagcatgacaatgagGatactgcttcagcttctggt	10	7	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:92921129G>A	uc003umo.2	+	13	1185	c.1057G>A	c.(1057-1059)GAT>AAT	p.D353N	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.D323N|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.D73N	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	353											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TGACAATGAGGATACTGCTTC	0.368													0	0	0	1	0	33	40										A	92921129	G	A	92921129	3	1	18	1	0	0	0	0	1	0	0	0	2767	1174	41	1	1149	1	CCDC132	7	92921129	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	83100	92921129	66217534	231	4805										
PON2	5445	broad.mit.edu	37	chr7	95039303	95039303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gactgtagtaaacaacatttGcccagtgtaagttcaagtat	8	7	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:95039303G>A	uc003unv.2	-	6	726	c.605C>T	c.(604-606)GCA>GTA	p.A202V	PON2_uc003unu.2_Missense_Mutation_p.A190V|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Missense_Mutation_p.A115V	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	202					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			AACAACATTTGCCCAGTGTAA	0.388													0	0	0	1	0	66	94										A	95039303	G	A	95039303	3	1	18	1	0	0	0	0	1	0	0	0	12249	1319	46	2	475	2	PON2	7	95039303	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2118174	95039303	64099360	232	4806										
SMURF1	57154	broad.mit.edu	37	chr7	98634777	98634777	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agagctaagaactgggcttcGattcctctcataaacctcca	7	12	1	2	rs148999069	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:98634777G>A	uc003upu.1	-	16	2120	c.1800C>T	c.(1798-1800)ATC>ATT	p.I600I	SMURF1_uc003upv.1_Silent_p.I574I|SMURF1_uc003upt.2_Silent_p.I574I	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	600	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			ACTGGGCTTCGATTCCTCTCA	0.468											OREG0018188	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	52	79										A	98634777	G	A	98634777	2	1	18	1	0	0	0	0	0	0	0	1	14819	1048	37	1		1	SMURF1	7	98634777	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3595474	98634777	60503886	233	4807										
PUS7	54517	broad.mit.edu	37	chr7	105111175	105111175	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tattcttcattccatattttGaaagtcctcgaagcagctgc	6	10	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:105111175G>C	uc003vcx.2	-	11	1577	c.1358C>G	c.(1357-1359)TCA>TGA	p.S453*	PUS7_uc010lji.2_Nonsense_Mutation_p.S459*|PUS7_uc003vcy.2_Nonsense_Mutation_p.S453*|PUS7_uc003vcz.1_Nonsense_Mutation_p.S453*	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	453	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TCCATATTTTGAAAGTCCTCG	0.423													0	0	0	1	0	92	109										C	105111175	G	C	105111175	4	2	18	1	0	0	0	0	0	1	0	0	12833	1294	45	1	651	1	PUS7	7	105111175	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6476398	105111175	54027488	234	4808										
LAMB4	22798	broad.mit.edu	37	chr7	107689947	107689947	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcagcagatgatgatatgtGataatatttcttgatgtttt	8	3	2	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:107689947G>A	uc010ljo.1	-	27	4030	c.3946C>T	c.(3946-3948)CAC>TAC	p.H1316Y	LAMB4_uc003vey.2_Missense_Mutation_p.H1316Y|LAMB4_uc010ljp.1_Missense_Mutation_p.H285Y	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1316	Domain II.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GATGATATGTGATAATATTTC	0.284													0	0	0	1	0	27	47										A	107689947	G	A	107689947	3	1	18	1	0	0	0	0	1	0	0	0	8613	1290	45	1	1371	1	LAMB4	7	107689947	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2578772	107689947	51448716	235	4809										
ZNF800	168850	broad.mit.edu	37	chr7	127014125	127014125	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctgtggagaatgggtaatgGaagggggtgaagattctaca	16	3	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:127014125G>C	uc003vlx.1	-	5	1528	c.1265C>G	c.(1264-1266)TCC>TGC	p.S422C	ZNF800_uc003vlw.1_Missense_Mutation_p.S325C|ZNF800_uc003vly.1_Missense_Mutation_p.S422C|ZNF800_uc010lla.2_Missense_Mutation_p.S422C	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATGGGTAATGGAAGGGGGTGA	0.353													0	0	0	1	0	55	84										C	127014125	G	C	127014125	3	2	18	1	0	0	0	0	1	0	0	0	18166	1174	41	1	737	1	ZNF800	7	127014125	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	19324178	127014125	32124538	236	4810										
KIAA1549	57670	broad.mit.edu	37	chr7	138604031	138604031	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgtatcaaaagtagtggcaGacggcggggctgtgacatgg	16	7	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:138604031G>C	uc011kql.1	-	2	390	c.341C>G	c.(340-342)TCT>TGT	p.S114C	KIAA1549_uc003vuk.3_Missense_Mutation_p.S64C|KIAA1549_uc011kqj.1_Missense_Mutation_p.S114C	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	114						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AGTAGTGGCAGACGGCGGGGC	0.517			O	BRAF	pilocytic astrocytoma								0	0	0	1	0	58	55										C	138604031	G	C	138604031	3	2	18	1	0	0	0	0	1	0	0	0	8244	942	33	1	5587	1	KIAA1549	7	138604031	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11589906	138604031	20534632	237	4811										
KLRG2	346689	broad.mit.edu	37	chr7	139168067	139168067	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggctcagccccgggcgcctCgccattccggggcagcttga	14	16	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:139168067C>G	uc003vvb.2	-	1	391	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	KLRG2_uc010lnc.2_Missense_Mutation_p.E108Q	NM_198508	NP_940910	A4D1S0	KLRG2_HUMAN	killer cell lectin-like receptor subfamily G,	108	Pro-rich.					integral to membrane	sugar binding			central_nervous_system(1)	1	Melanoma(164;0.233)					CCGGGCGCCTCGCCATTCCGG	0.771													0	0	0	1	0	6	6										G	139168067	C	G	139168067	3	3	18	1	0	0	0	0	1	0	0	0	8422	893	31	1	927	1	KLRG2	7	139168067	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	564036	139168067	19970596	238	4812										
DENND2A	27147	broad.mit.edu	37	chr7	140258011	140258011	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	taagacaaatgagaatgtttCactgtggttgggaaaacaca	10	5	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:140258011C>T	uc010lnj.2	-	9	2036	c.1891G>A	c.(1891-1893)GAA>AAA	p.E631K	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.E631K|DENND2A_uc003vvw.2_Missense_Mutation_p.E631K|DENND2A_uc003vvx.2_Missense_Mutation_p.E631K	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	631	UDENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GAGAATGTTTCACTGTGGTTG	0.473													0	0	0	1	0	29	32										T	140258011	C	T	140258011	3	4	18	1	0	0	0	0	1	0	0	0	4429	840	29	1	1178	1	DENND2A	7	140258011	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1089944	140258011	18880652	239	4813										
C7orf33	202865	broad.mit.edu	37	chr7	148288196	148288196	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cggtccaggtcaatttaactTgtcatatgccacgggaagac	10	10	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:148288196T>A	uc003wew.2	+	1	540	c.179T>A	c.(178-180)TTG>TAG	p.L60*		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	60										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CAATTTAACTTGTCATATGCC	0.493													0	0	0	1	0	61	87										A	148288196	T	A	148288196	4	1	18	1	0	0	0	0	0	1	0	0	2388	1821	63	5	181	5	C7orf33	7	148288196	Nonsense_Mutation	SNP	T	TCGA-BT-A3PH-01A-11D-A21Z-08	8030185	148288196	10850467	240	4814										
ZNF777	27153	broad.mit.edu	37	chr7	149153043	149153043	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttctcgggggagtccagcaGgggcctgacgtaaggtttct	15	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:149153043G>A	uc003wfv.2	-	2	234	c.71C>T	c.(70-72)CCT>CTT	p.P24L		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GAGTCCAGCAGGGGCCTGACG	0.547													0	0	0	1	0	39	54										A	149153043	G	A	149153043	3	1	18	1	0	0	0	0	1	0	0	0	18147	1000	35	2	2444	2	ZNF777	7	149153043	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	864847	149153043	9985620	241	4815										
KRBA1	84626	broad.mit.edu	37	chr7	149419541	149419541	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gacaaaccgtggcctacaagGaaggaaggcccaggagccct	13	12	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:149419541G>A	uc003wfz.2	+	6	894	c.495G>A	c.(493-495)AGG>AGA	p.R165R	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_5'Flank	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	165										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCTACAAGGAAGGAAGGCC	0.607													0	0	0	1	0	3	9										A	149419541	G	A	149419541	2	1	18	1	0	0	0	0	0	0	0	1	8439	1165	41	1		1	KRBA1	7	149419541	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	266498	149419541	9719122	242	4816										
NOS3	4846	broad.mit.edu	37	chr7	150699303	150699303	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cacaggtcctgtgtatggatGagtatgacgtggtgtccctc	13	9	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:150699303G>A	uc003wif.2	+	14	1959	c.1663G>A	c.(1663-1665)GAG>AAG	p.E555K	NOS3_uc011kuy.1_Missense_Mutation_p.E349K|NOS3_uc011kuz.1_Missense_Mutation_p.E555K|NOS3_uc011kva.1_Missense_Mutation_p.E555K|NOS3_uc011kvb.1_Missense_Mutation_p.E555K	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	555	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GTGTATGGATGAGTATGACGT	0.602													0	0	0	1	0	6	12										A	150699303	G	A	150699303	3	1	18	1	0	0	0	0	1	0	0	0	10544	1291	45	1	1713	1	NOS3	7	150699303	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1279762	150699303	8439360	243	4817										
MLL3	58508	broad.mit.edu	37	chr7	151877000	151877000	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttttgggaaaacagcatatCtaggtcctaaaggaggggca	12	7	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:151877000C>G	uc003wla.2	-	37	7580	c.7361G>C	c.(7360-7362)AGA>ACA	p.R2454T	MLL3_uc003wkz.2_Missense_Mutation_p.R1515T|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2454	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AACAGCATATCTAGGTCCTAA	0.478			N		medulloblastoma								0	0	0	1	0	86	99										G	151877000	C	G	151877000	3	3	18	1	0	0	0	0	1	0	0	0	9622	913	32	1	7466	1	MLL3	7	151877000	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1177697	151877000	7261663	244	4818										
MLL3	58508	broad.mit.edu	37	chr7	151878836	151878836	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaaaggtccaggaccactatCaagaggtgcaggtgtcaaca	11	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:151878836C>G	uc003wla.2	-	36	6328	c.6109G>C	c.(6109-6111)GAT>CAT	p.D2037H	MLL3_uc003wkz.2_Missense_Mutation_p.D1098H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2037	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGACCACTATCAAGAGGTGCA	0.468			N		medulloblastoma								0	0	0	1	0	53	74										G	151878836	C	G	151878836	3	3	18	1	0	0	0	0	1	0	0	0	9622	826	29	1	8722	1	MLL3	7	151878836	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1836	151878836	7259827	245	4819										
MLL3	58508	broad.mit.edu	37	chr7	151945114	151945114	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagcagaggaactaagagctGaagggtaattatgcagcatg	13	6	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr7:151945114G>A	uc003wla.2	-	14	2624	c.2405C>T	c.(2404-2406)TCA>TTA	p.S802L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	802					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACTAAGAGCTGAAGGGTAATT	0.423			N		medulloblastoma								0	0	0	1	0	37	740										A	151945114	G	A	151945114	3	1	18	1	0	0	0	0	1	0	0	0	9622	1294	45	1	12514	1	MLL3	7	151945114	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	66278	151945114	7193549	246	4820										
PCM1	5108	broad.mit.edu	37	chr8	17813081	17813081	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atccaatagcctcacatcatCtgttccttatcctactgctt	3	14	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:17813081C>G	uc003wyi.3	+	10	1813	c.1391C>G	c.(1390-1392)TCT>TGT	p.S464C	PCM1_uc011kyh.1_Missense_Mutation_p.S464C|PCM1_uc003wyj.3_Missense_Mutation_p.S464C|PCM1_uc003wyh.2_Missense_Mutation_p.S503C|PCM1_uc010lta.1_Missense_Mutation_p.S503C	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	464					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		CTCACATCATCTGTTCCTTAT	0.433			T	RET|JAK2	papillary thyroid|CML|MPD								0	0	0	1	0	23	33										G	17813081	C	G	17813081	3	3	18	1	0	0	0	0	1	0	0	0	11584	913	32	1	1421	1	PCM1	8	17813081	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		17813081	128550941	247	4821										
CHD7	55636	broad.mit.edu	37	chr8	61654025	61654025	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaatgatgagtctttttggcGaggatgggaatattttcagt	13	3	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:61654025G>A	uc003xue.2	+	2	511	c.34G>A	c.(34-36)GAG>AAG	p.E12K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	12					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCTTTTTGGCGAGGATGGGAA	0.488													0	0	0	1	0	13	9										A	61654025	G	A	61654025	3	1	18	1	0	0	0	0	1	0	0	0	3330	1059	37	1	36	1	CHD7	8	61654025	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	43840944	61654025	84709997	248	4822										
KCNB2	9312	broad.mit.edu	37	chr8	73848265	73848265	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caggaaacggacgaatttggAcaactcaatgacaaccgcca	9	11	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:73848265A>G	uc003xzb.2	+	3	1263	c.675A>G	c.(673-675)GGA>GGG	p.G225G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	225					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACGAATTTGGACAACTCAATG	0.468													0	0	0	1	0	60	73										G	73848265	A	G	73848265	2	3	18	1	0	0	0	0	0	0	0	1	8013	262	10	5		5	KCNB2	8	73848265	Silent	SNP	A	TCGA-BT-A3PH-01A-11D-A21Z-08	12194240	73848265	72515757	249	4823										
RALYL	138046	broad.mit.edu	37	chr8	85785626	85785626	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgagaaacagcagaaggcgGaggcaggtaagtgatctctg	15	6	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:85785626G>C	uc003ycq.3	+	8	1095	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	RALYL_uc003ycr.3_Missense_Mutation_p.E227Q|RALYL_uc003ycs.3_Missense_Mutation_p.E227Q|RALYL_uc010lzy.2_Missense_Mutation_p.E216Q|RALYL_uc003yct.3_Missense_Mutation_p.E240Q|RALYL_uc003ycu.3_Missense_Mutation_p.E154Q|RALYL_uc003ycv.3_Missense_Mutation_p.E139Q	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	227	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						GCAGAAGGCGGAGGCAGGTAA	0.463													0	0	0	1	0	4	4										C	85785626	G	C	85785626	3	2	18	1	0	0	0	0	1	0	0	0	13020	1175	41	1	744	1	RALYL	8	85785626	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11937361	85785626	60578396	250	4824										
ESRP1	54845	broad.mit.edu	37	chr8	95680397	95680397	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcctgtgaggaatatgcacaGaatgcgttgaggaagcataa	13	6	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:95680397G>C	uc003ygq.3	+	10	1335	c.1152G>C	c.(1150-1152)CAG>CAC	p.Q384H	ESRP1_uc003ygr.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygs.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygt.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygu.3_Missense_Mutation_p.Q384H|ESRP1_uc003ygv.2_Missense_Mutation_p.Q224H|ESRP1_uc003ygw.2_Missense_Mutation_p.Q224H	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	384	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AATATGCACAGAATGCGTTGA	0.458													0	0	0	1	0	47	50										C	95680397	G	C	95680397	3	2	18	1	0	0	0	0	1	0	0	0	5258	933	33	1	1190	1	ESRP1	8	95680397	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	9894771	95680397	50683625	251	4825										
UBR5	51366	broad.mit.edu	37	chr8	103323975	103323975	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcctctacctgtccagcagtGaaaatggctacattcctctc	7	14	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:103323975G>A	uc003ykr.1	-	19	2439	c.2406C>T	c.(2404-2406)TTC>TTT	p.F802F	UBR5_uc003yks.1_Silent_p.F802F	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	802					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GTCCAGCAGTGAAAATGGCTA	0.413													0	0	0	1	0	105	90										A	103323975	G	A	103323975	2	1	18	1	0	0	0	0	0	0	0	1	16902	1281	45	1		1	UBR5	8	103323975	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7643578	103323975	43040047	252	4826										
PKHD1L1	93035	broad.mit.edu	37	chr8	110492333	110492333	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgcagaatcttcttacagaGaagttgttttgaatgctacc	8	8	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:110492333G>C	uc003yne.2	+	55	9396	c.9292G>C	c.(9292-9294)GAA>CAA	p.E3098Q		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3098	Extracellular (Potential).|G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCTTACAGAGAAGTTGTTTT	0.353										HNSCC(38;0.096)			0	0	0	1	0	5	3										C	110492333	G	C	110492333	3	2	18	1	0	0	0	0	1	0	0	0	11972	943	33	1	9510	1	PKHD1L1	8	110492333	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7168358	110492333	35871689	253	4827										
DEPDC6	64798	broad.mit.edu	37	chr8	120977541	120977541	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtcaagtatgagcgcaccttCatggcatctgaattcctgga	10	10	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:120977541C>T	uc003yow.3	+	4	682	c.495C>T	c.(493-495)TTC>TTT	p.F165F	DEPDC6_uc011lid.1_Silent_p.F64F	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	165	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AGCGCACCTTCATGGCATCTG	0.532													0	0	0	1	0	41	61										T	120977541	C	T	120977541	2	4	18	1	0	0	0	0	0	0	0	1	4443	825	29	1		1	DEPDC6	8	120977541	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10485208	120977541	25386481	254	4828										
WISP1	8840	broad.mit.edu	37	chr8	134239872	134239872	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctatggattaatgcctgcttCtgtaacctgagctgtaggaa	10	8	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:134239872C>T	uc003yub.2	+	5	1099	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	WISP1_uc003yuc.2_Silent_p.F254F|WISP1_uc010meb.2_Silent_p.F169F|WISP1_uc010mec.2_3'UTR|WISP1_uc010med.2_Silent_p.F96F|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	341	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ATGCCTGCTTCTGTAACCTGA	0.502													0	0	0	1	0	61	59										T	134239872	C	T	134239872	2	4	18	1	0	0	0	0	0	0	0	1	17369	912	32	1		1	WISP1	8	134239872	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	13262331	134239872	12124150	255	4829										
NDRG1	10397	broad.mit.edu	37	chr8	134266798	134266798	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcaccttcccaaaaaggtggGacaccaccatgtccggcaga	9	14	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:134266798G>C	uc003yuh.2	-	9	1164	c.578C>G	c.(577-579)TCC>TGC	p.S193C	NDRG1_uc003yuf.1_Missense_Mutation_p.S4C|NDRG1_uc003yug.2_Missense_Mutation_p.S193C|NDRG1_uc010mee.2_Missense_Mutation_p.S112C|NDRG1_uc010mef.2_Missense_Mutation_p.S127C|NDRG1_uc011ljh.1_Missense_Mutation_p.S21C|NDRG1_uc011lji.1_Intron	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	193					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AAAAAGGTGGGACACCACCAT	0.537													0	0	0	1	0	24	35										C	134266798	G	C	134266798	3	2	18	1	0	0	0	0	1	0	0	0	10251	1174	41	1	638	1	NDRG1	8	134266798	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	26926	134266798	12097224	256	4830										
SLC45A4	57210	broad.mit.edu	37	chr8	142229062	142229062	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cctggttctgggtccggaacCagctgcccaggaaggtctgg	15	12	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:142229062C>T	uc003ywd.1	-	4	832	c.524G>A	c.(523-525)TGG>TAG	p.W175*	SLC45A4_uc003ywc.1_Nonsense_Mutation_p.W175*|SLC45A4_uc010meq.1_Nonsense_Mutation_p.W173*	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	226					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGTCCGGAACCAGCTGCCCAG	0.647													0	0	0	1	0	89	89										T	142229062	C	T	142229062	4	4	18	1	0	0	0	0	0	1	0	0	14643	595	21	2	1892	2	SLC45A4	8	142229062	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7962264	142229062	4134960	257	4831										
ZNF623	9831	broad.mit.edu	37	chr8	144732634	144732634	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	attcaggtctcattgagcatCagcgcgttcattcaggagaa	10	9	5	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:144732634C>G	uc003yzd.2	+	1	681	c.592C>G	c.(592-594)CAG>GAG	p.Q198E	ZNF623_uc011lkp.1_Missense_Mutation_p.Q158E|ZNF623_uc003yzc.2_Missense_Mutation_p.Q158E	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	198	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CATTGAGCATCAGCGCGTTCA	0.473													0	0	0	1	0	57	62										G	144732634	C	G	144732634	3	3	18	1	0	0	0	0	1	0	0	0	18044	827	29	1	594	1	ZNF623	8	144732634	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2503572	144732634	1631388	258	4832										
EPPK1	83481	broad.mit.edu	37	chr8	144946756	144946756	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcaaggctagccccgagccGggggcacgcacacacctttc	12	16	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:144946756G>A	uc003zaa.1	-	1	679	c.666C>T	c.(664-666)CCC>CCT	p.P222P		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	222	Plectin 5.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCCCGAGCCGGGGGCACGCA	0.662													0	0	0	1	0	11	16										A	144946756	G	A	144946756	2	1	18	1	0	0	0	0	0	0	0	1	5190	1103	39	2		2	EPPK1	8	144946756	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	214122	144946756	1417266	259	4833										
EXOSC4	54512	broad.mit.edu	37	chr8	145134907	145134907	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtgaactgtcaatatagttCagcgaccttcagcacaggtg	10	9	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:145134907C>T	uc003zau.2	+	2	343	c.233C>T	c.(232-234)TCA>TTA	p.S78L	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	78					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAATATAGTTCAGCGACCTTC	0.617													0	0	0	1	0	104	145										T	145134907	C	T	145134907	3	4	18	1	0	0	0	0	1	0	0	0	5317	838	29	1	239	1	EXOSC4	8	145134907	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	188151	145134907	1229115	260	4834										
NFKBIL2	4796	broad.mit.edu	37	chr8	145661307	145661307	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtcaggggcatgtccagctCcagccagtccccggccaggc	14	16	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr8:145661307C>T	uc011llg.1	-	17	2524	c.2509G>A	c.(2509-2511)GAG>AAG	p.E837K	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	837					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			ATGTCCAGCTCCAGCCAGTCC	0.622													0	0	0	1	0	9	17										T	145661307	C	T	145661307	3	4	18	1	0	0	0	0	1	0	0	0	10382	864	30	1	1667	1	NFKBIL2	8	145661307	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	526400	145661307	702715	261	4835										
DOCK8	81704	broad.mit.edu	37	chr9	446486	446486	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcatgtacaccaccccgttCaccctggaggggcggcctcg	11	16	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:446486C>G	uc003zgf.2	+	44	5809	c.5697C>G	c.(5695-5697)TTC>TTG	p.F1899L	DOCK8_uc010mgu.2_Missense_Mutation_p.F1201L|DOCK8_uc010mgv.2_Missense_Mutation_p.F1799L|DOCK8_uc003zgk.2_Missense_Mutation_p.F1357L	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1899					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CCACCCCGTTCACCCTGGAGG	0.522													0	0	0	1	0	67	99										G	446486	C	G	446486	3	3	18	1	0	0	0	0	1	0	0	0	4693	825	29	1	5871	1	DOCK8	9	446486	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		446486	140766945	262	4836										
RFX3	5991	broad.mit.edu	37	chr9	3257090	3257090	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcatcatcacattgtcaagcCacgcagcccactgctccagg	8	16	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:3257090C>T	uc003zhr.2	-	15	2027	c.1715G>A	c.(1714-1716)TGG>TAG	p.W572*	RFX3_uc010mhd.2_Nonsense_Mutation_p.W572*|RFX3_uc003zhs.1_Nonsense_Mutation_p.W572*	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	572					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		ATTGTCAAGCCACGCAGCCCA	0.498													0	0	0	1	0	64	71										T	3257090	C	T	3257090	4	4	18	1	0	0	0	0	0	1	0	0	13264	595	21	2	706	2	RFX3	9	3257090	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2810604	3257090	137956341	263	4837										
FREM1	158326	broad.mit.edu	37	chr9	14824958	14824958	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggagcctcttttggaagctgGtcatccactggagttatatg	12	8	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:14824958G>A	uc003zlm.2	-	11	2504	c.1914C>T	c.(1912-1914)GAC>GAT	p.D638D	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	638	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTGGAAGCTGGTCATCCACTG	0.383													0	0	0	1	0	28	33										A	14824958	G	A	14824958	2	1	18	1	0	0	0	0	0	0	0	1	6044	1252	44	2		2	FREM1	9	14824958	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	11567868	14824958	126388473	264	4838										
PTPLAD2	401494	broad.mit.edu	37	chr9	21007098	21007098	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcttctttctgagtatagatGactgtaggtaaaatacatac	7	6	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:21007098G>T	uc010miq.1	-	7	683	c.637C>A	c.(637-639)CAT>AAT	p.H213N	PTPLAD2_uc003zoj.1_Missense_Mutation_p.H176N|PTPLAD2_uc010mir.1_Missense_Mutation_p.H213N	NM_001010915	NP_001010915	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain	213	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			skin(1)	1				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		GAGTATAGATGACTGTAGGTA	0.348													1	0	2.80507e-11	1	2.86585e-11	27	50										T	21007098	G	T	21007098	3	4	18	1	0	0	0	0	1	0	0	0	12776	1290	45	3	65	3	PTPLAD2	9	21007098	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6182140	21007098	120206333	265	4839										
UBAP2	55833	broad.mit.edu	37	chr9	33927842	33927842	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tactgctgctggatgcactcGcgggggtcccacccagacag	13	14	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:33927842G>A	uc003ztq.1	-	20	2437	c.2324C>T	c.(2323-2325)GCG>GTG	p.A775V	UBAP2_uc011loc.1_Missense_Mutation_p.A684V|UBAP2_uc011lod.1_Missense_Mutation_p.A508V|UBAP2_uc011loe.1_Missense_Mutation_p.A530V|UBAP2_uc011lof.1_Missense_Mutation_p.A700V|UBAP2_uc011log.1_3'UTR|UBAP2_uc003ztn.1_Missense_Mutation_p.A14V|UBAP2_uc003zto.1_Missense_Mutation_p.A14V|UBAP2_uc003ztp.1_Missense_Mutation_p.A14V	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	775										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GGATGCACTCGCGGGGGTCCC	0.642													0	0	0	1	0	84	106										A	33927842	G	A	33927842	3	1	18	1	0	0	0	0	1	0	0	0	16834	1087	38	2	1075	2	UBAP2	9	33927842	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	12920744	33927842	107285589	266	4840										
KIAA1045	23349	broad.mit.edu	37	chr9	34976667	34976667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgccctggaccctgaacatcGaggccacatagagtggcctg	12	13	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:34976667G>A	uc003zvq.2	+	5	957	c.779G>A	c.(778-780)CGA>CAA	p.R260Q	KIAA1045_uc003zvr.2_Missense_Mutation_p.R260Q	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	260							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			CCTGAACATCGAGGCCACATA	0.632													0	0	0	1	0	51	77										A	34976667	G	A	34976667	3	1	18	1	0	0	0	0	1	0	0	0	8207	1058	37	1	793	1	KIAA1045	9	34976667	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1048825	34976667	106236764	267	4841										
SMC5	23137	broad.mit.edu	37	chr9	72962016	72962016	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccaaacacattggatgaaaTtgatgctttattaactgaag	7	6	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:72962016T>C	uc004ahr.2	+	20	2720	c.2603T>C	c.(2602-2604)ATT>ACT	p.I868T	SMC5_uc011lry.1_Missense_Mutation_p.I13T	NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	868					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						TTGGATGAAATTGATGCTTTA	0.368													0	0	0	1	0	31	34										C	72962016	T	C	72962016	3	2	18	1	0	0	0	0	1	0	0	0	14786	1493	52	5	2681	5	SMC5	9	72962016	Missense_Mutation	SNP	T	TCGA-BT-A3PH-01A-11D-A21Z-08	37985349	72962016	68251415	268	4842										
TRPM6	140803	broad.mit.edu	37	chr9	77390846	77390846	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgtgaggagctcgatgacagCacaggcggcggaggagaagg	19	8	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:77390846C>A	uc004ajl.1	-	24	3594	c.3356G>T	c.(3355-3357)TGC>TTC	p.C1119F	TRPM6_uc004ajk.1_Missense_Mutation_p.C1114F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.C75F	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1119	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TCGATGACAGCACAGGCGGCG	0.542													1	0	2.40265e-35	1	2.54814e-35	50	100										A	77390846	C	A	77390846	3	1	18	1	0	0	0	0	1	0	0	0	16587	710	25	4	2776	4	TRPM6	9	77390846	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4428830	77390846	63822585	269	4843										
PCSK5	5125	broad.mit.edu	37	chr9	78796359	78796359	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggccactaccacgccgacaaGaagcgctgcaggaagtgtgc	13	13	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:78796359G>C	uc004ajz.2	+	16	2587	c.2049G>C	c.(2047-2049)AAG>AAC	p.K683N	PCSK5_uc004aka.2_RNA|PCSK5_uc004akb.2_5'UTR	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	683	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						ACGCCGACAAGAAGCGCTGCA	0.522													0	0	0	1	0	26	52										C	78796359	G	C	78796359	3	2	18	1	0	0	0	0	1	0	0	0	11603	933	33	1	2111	1	PCSK5	9	78796359	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1405513	78796359	62417072	270	4844										
PSAT1	29968	broad.mit.edu	37	chr9	80912185	80912185	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcccgccaagctgccgcactCagtaagtccccgcgagcggg	12	17	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:80912185C>G	uc004ala.2	+	1	127	c.59C>G	c.(58-60)TCA>TGA	p.S20*	PSAT1_uc004alb.2_Nonsense_Mutation_p.S20*	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1 isoform 1	20					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	CTGCCGCACTCAGTAAGTCCC	0.697													0	0	0	1	0	14	14										G	80912185	C	G	80912185	4	3	18	1	0	0	0	0	0	1	0	0	12644	840	29	1	61	1	PSAT1	9	80912185	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2115826	80912185	60301246	271	4845										
KIF27	55582	broad.mit.edu	37	chr9	86485462	86485462	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtctatacttccaaacgaaCcttttctccttttcaagtta	4	11	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:86485462C>G	uc004ana.2	-	12	2873	c.2729G>C	c.(2728-2730)GGT>GCT	p.G910A	KIF27_uc010mpw.2_Missense_Mutation_p.G844A|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	910					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TCCAAACGAACCTTTTCTCCT	0.348													0	0	0	1	0	26	34										G	86485462	C	G	86485462	3	3	18	1	0	0	0	0	1	0	0	0	8296	507	18	4	1504	4	KIF27	9	86485462	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5573277	86485462	54727969	272	4846										
ANP32B	10541	broad.mit.edu	37	chr9	100756947	100756947	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttggacaattgcaaatcaaAtgatggaaaaattgagggct	10	5	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:100756947A>T	uc004aya.2	+	2	438	c.89A>T	c.(88-90)AAT>ATT	p.N30I		NM_006401	NP_006392	Q92688	AN32B_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	30	LRR 1.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(62;0.0559)				TGCAAATCAAATGATGGAAAA	0.363													0	0	0	1	0	32	52										T	100756947	A	T	100756947	3	4	18	1	0	0	0	0	1	0	0	0	706	101	4	5	95	5	ANP32B	9	100756947	Missense_Mutation	SNP	A	TCGA-BT-A3PH-01A-11D-A21Z-08	14271485	100756947	40456484	273	4847										
OR13C4	138804	broad.mit.edu	37	chr9	107289386	107289386	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgccaattagaatcactacGtacataactagaatcagagc	6	9	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:107289386G>A	uc011lvn.1	-	1	105	c.105C>T	c.(103-105)TAC>TAT	p.Y35Y		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAATCACTACGTACATAACTA	0.413													0	0	0	1	0	68	81										A	107289386	G	A	107289386	2	1	18	1	0	0	0	0	0	0	0	1	10936	1140	40	2		2	OR13C4	9	107289386	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6532439	107289386	33924045	274	4848										
FBXW2	26190	broad.mit.edu	37	chr9	123550366	123550366	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agctccaggggaaggagtttGaggaagtcccgcttgaggag	17	7	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:123550366G>C	uc004bkl.1	-	3	332	c.171C>G	c.(169-171)CTC>CTG	p.L57L	FBXW2_uc011lyc.1_5'UTR|FBXW2_uc004bkn.2_Silent_p.L89L|FBXW2_uc004bkm.1_Silent_p.L57L|FBXW2_uc010mvj.1_Silent_p.L57L	NM_012164	NP_036296	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2	57	F-box.				proteolysis		protein binding|ubiquitin-protein ligase activity			urinary_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						GAAGGAGTTTGAGGAAGTCCC	0.463													0	0	0	1	0	45	64										C	123550366	G	C	123550366	2	2	18	1	0	0	0	0	0	0	0	1	5766	1277	45	1		1	FBXW2	9	123550366	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	16260980	123550366	17663065	275	4849										
C5	727	broad.mit.edu	37	chr9	123737147	123737147	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaaacatcgatgtccatactCaagcggagttgtttaaccag	9	9	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:123737147C>G	uc004bkv.2	-	30	3957	c.3927G>C	c.(3925-3927)TTG>TTC	p.L1309F		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1309					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TGTCCATACTCAAGCGGAGTT	0.403													0	0	0	1	0	101	131										G	123737147	C	G	123737147	3	3	18	1	0	0	0	0	1	0	0	0	2280	825	29	1	1151	1	C5	9	123737147	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	186781	123737147	17476284	276	4850										
ZBTB6	10773	broad.mit.edu	37	chr9	125673538	125673538	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcacaaaataagccctgatCttgattcccaggaacttcag	6	12	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:125673538C>G	uc004bnh.2	-	2	903	c.814G>C	c.(814-816)GAT>CAT	p.D272H		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGCCCTGATCTTGATTCCCA	0.428													0	0	0	1	0	23	39										G	125673538	C	G	125673538	3	3	18	1	0	0	0	0	1	0	0	0	17549	913	32	1	464	1	ZBTB6	9	125673538	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1936391	125673538	15539893	277	4851										
ZBTB6	10773	broad.mit.edu	37	chr9	125673781	125673781	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctctctgatgtcagactctCtactgtagactgcaaagcat	7	11	4	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:125673781C>G	uc004bnh.2	-	2	660	c.571G>C	c.(571-573)GAG>CAG	p.E191Q		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCAGACTCTCTACTGTAGAC	0.353													0	0	0	1	0	35	36										G	125673781	C	G	125673781	3	3	18	1	0	0	0	0	1	0	0	0	17549	922	32	1	707	1	ZBTB6	9	125673781	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	243	125673781	15539650	278	4852										
GOLGA1	2800	broad.mit.edu	37	chr9	127689002	127689002	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	actaaccttttcaagctgatCcatcttttctgaccattcct	3	13	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:127689002C>G	uc004bpc.2	-	7	760	c.418G>C	c.(418-420)GAT>CAT	p.D140H	GOLGA1_uc010mws.2_RNA|GOLGA1_uc010mwt.1_Missense_Mutation_p.D115H	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	140	Potential.					Golgi cisterna membrane				ovary(1)	1						TCAAGCTGATCCATCTTTTCT	0.343													0	0	0	1	0	53	113										G	127689002	C	G	127689002	3	3	18	1	0	0	0	0	1	0	0	0	6551	855	30	1	1953	1	GOLGA1	9	127689002	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2015221	127689002	13524429	279	4853										
GOLGA1	2800	broad.mit.edu	37	chr9	127691529	127691529	+	Silent	SNP	C	C	T													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctaatgcaatttcaagcttCtcttttatcttctgcaagtt							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:127691529C>T	uc004bpc.2	-	5	609	c.267G>A	c.(265-267)GAG>GAA	p.E89E	GOLGA1_uc010mws.2_5'Flank|GOLGA1_uc010mwt.1_Intron	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	89	Potential.					Golgi cisterna membrane				ovary(1)	1						TTTCAAGCTTCTCTTTTATCT	0.368													0	0	0	1	0	5	41										T	127691529	C	T	127691529	2	4	18	1	0	0	0	0	0	0	0	1	6551	912	32	1		1	GOLGA1	9	127691529	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2527	127691529	13521902	280	4854	24	2								
GOLGA1	2800	broad.mit.edu	37	chr9	127691531	127691531	+	Missense_Mutation	SNP	C	C	T													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	taatgcaatttcaagcttctCttttatcttctgcaagtttc							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:127691531C>T	uc004bpc.2	-	5	607	c.265G>A	c.(265-267)GAG>AAG	p.E89K	GOLGA1_uc010mws.2_5'Flank|GOLGA1_uc010mwt.1_Intron	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	89	Potential.					Golgi cisterna membrane				ovary(1)	1						TCAAGCTTCTCTTTTATCTTC	0.363													0	0	0	1	0	5	42										T	127691531	C	T	127691531	3	4	18	1	0	0	0	0	1	0	0	0	6551	922	32	1	2114	1	GOLGA1	9	127691531	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2	127691531	13521900	281	4855	24	2								
NUP188	23511	broad.mit.edu	37	chr9	131767776	131767776	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctggcagccctgcgccacttCaccccagatgtctgccagat	9	17	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:131767776C>T	uc004bws.1	+	40	4726	c.4704C>T	c.(4702-4704)TTC>TTT	p.F1568F		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1568					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TGCGCCACTTCACCCCAGATG	0.577													0	0	0	1	0	40	61										T	131767776	C	T	131767776	2	4	18	1	0	0	0	0	0	0	0	1	10758	825	29	1		1	NUP188	9	131767776	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4076245	131767776	9445655	282	4856										
BARHL1	56751	broad.mit.edu	37	chr9	135464731	135464731	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctacccgcagagtctggtttCcaacctggaccccggcgcgg	12	16	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:135464731C>G	uc004cbp.1	+	3	998	c.806C>G	c.(805-807)TCC>TGC	p.S269C		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	269						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		AGTCTGGTTTCCAACCTGGAC	0.672													0	0	0	1	0	90	99										G	135464731	C	G	135464731	3	3	18	1	0	0	0	0	1	0	0	0	1313	855	30	1	816	1	BARHL1	9	135464731	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3696955	135464731	5748700	283	4857										
CEL	1056	broad.mit.edu	37	chr9	135947083	135947083	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgccccccacgggtgactctGaggctgcccctgtgcccccc	11	20	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:135947083G>A	uc010naa.1	+	11	2219	c.2203G>A	c.(2203-2205)GAG>AAG	p.E735K		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	732	16.|17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GGGTGACTCTGAGGCTGCCCC	0.682													0	0	0	1	0	27	30										A	135947083	G	A	135947083	3	1	18	1	0	0	0	0	1	0	0	0	3209	1291	45	1	2245	1	CEL	9	135947083	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	482352	135947083	5266348	284	4858										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													0	0	0	1	0	71	105										T	137328351	C	T	137328351	3	4	18	1	0	0	0	0	1	0	0	0	13763	855	30	1	1318	1	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1381268	137328351	3885080	285	4859										
SDCCAG3	10807	broad.mit.edu	37	chr9	139303520	139303520	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccctttccatagccaaaatCtgcaaagaaacaatgtcacc	4	14	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:139303520C>G	uc004chi.2	-	3	426	c.221_splice	c.e3-1	p.D74_splice	SDCCAG3_uc004chj.2_Intron|SDCCAG3_uc004chk.2_Intron|PMPCA_uc011mdy.1_5'Flank|PMPCA_uc010nbk.2_5'Flank|PMPCA_uc004chl.2_5'Flank|PMPCA_uc010nbl.2_5'Flank|PMPCA_uc011mdz.1_5'Flank	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3							cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		TAGCCAAAATCTGCAAAGAAA	0.458													0	0	0	1	0	47	96										G	139303520	C	G	139303520	5	3	18	1	0	0	0	0	0	0	1	0	13958	927	32	1	1119	1	SDCCAG3	9	139303520	Splice_Site	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1975169	139303520	1909911	286	4860										
MAN1B1	11253	broad.mit.edu	37	chr9	140003028	140003028	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaagcccaccctctgcctatCtggacccctgcctagggtgg	11	16	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:140003028C>G	uc004cld.2	+	13	2120	c.2085C>G	c.(2083-2085)ATC>ATG	p.I695M	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.I368M|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	695	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CTCTGCCTATCTGGACCCCTG	0.597													0	0	0	1	0	121	153										G	140003028	C	G	140003028	3	3	18	1	0	0	0	0	1	0	0	0	9212	903	32	1	2135	1	MAN1B1	9	140003028	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	699508	140003028	1210403	287	4861										
RNF208	727800	broad.mit.edu	37	chr9	140115104	140115104	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acagtctcacggcggcaggtGgggcaggagatgaacttgta	16	8	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:140115104G>C	uc004clz.1	-	1	672	c.561C>G	c.(559-561)CCC>CCG	p.P187P		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	187	RING-type.						zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGCGGCAGGTGGGGCAGGAGA	0.652													0	0	0	1	0	14	42										C	140115104	G	C	140115104	2	2	18	1	0	0	0	0	0	0	0	1	13475	1335	47	4		4	RNF208	9	140115104	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	112076	140115104	1098327	288	4862										
RNF208	727800	broad.mit.edu	37	chr9	140115581	140115581	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atcttcatggcctccatcttGaggatgacatggggaccctt	10	11	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr9:140115581G>T	uc004clz.1	-	1	195	c.84C>A	c.(82-84)CTC>CTA	p.L28L		NM_031297	NP_112587	Q9H0X6	RN208_HUMAN	ring finger protein 208	28							zinc ion binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CCTCCATCTTGAGGATGACAT	0.662													1	0	0.00152264	1	0.00153264	17	22										T	140115581	G	T	140115581	2	4	18	1	0	0	0	0	0	0	0	1	13475	1277	45	3		3	RNF208	9	140115581	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	477	140115581	1097850	289	4863										
DHTKD1	55526	broad.mit.edu	37	chr10	12139993	12139993	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acctgctgaagacacatgttCaggtgggcagcctccaaatg	11	11	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:12139993C>G	uc001ild.3	+	8	1768	c.1669C>G	c.(1669-1671)CAG>GAG	p.Q557E		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	557					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GACACATGTTCAGGTGGGCAG	0.502													0	0	0	1	0	42	58										G	12139993	C	G	12139993	3	3	18	1	0	0	0	0	1	0	0	0	4500	827	29	1	1699	1	DHTKD1	10	12139993	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		12139993	123394754	290	4864										
CAMK1D	57118	broad.mit.edu	37	chr10	12811675	12811675	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcttattttctttctagcccGaaaatctcttgtactacagt	4	10	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:12811675G>A	uc001ilo.2	+	5	677	c.442G>A	c.(442-444)GAA>AAA	p.E148K	CAMK1D_uc001iln.2_Missense_Mutation_p.E148K	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	148	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		TTTCTAGCCCGAAAATCTCTT	0.388													0	0	0	1	0	28	27										A	12811675	G	A	12811675	3	1	18	1	0	0	0	0	1	0	0	0	2597	1059	37	1	460	1	CAMK1D	10	12811675	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	671682	12811675	122723072	291	4865										
ERCC6	2074	broad.mit.edu	37	chr10	50682233	50682233	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgagattcttgggacctccaGaaaagagatcagggtggttg	14	6	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:50682233G>A	uc001jhs.3	-	13	2592	c.2438C>T	c.(2437-2439)TCT>TTT	p.S813F	ERCC6_uc009xod.2_5'UTR|ERCC6_uc010qgr.1_Missense_Mutation_p.S183F|ERCC6_uc001jhr.3_Missense_Mutation_p.S181F	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	813					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GGGACCTCCAGAAAAGAGATC	0.413								Direct_reversal_of_damage|NER					0	0	0	1	0	54	62										A	50682233	G	A	50682233	3	1	18	1	0	0	0	0	1	0	0	0	5217	942	33	1	2079	1	ERCC6	10	50682233	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	37870558	50682233	84852514	292	4866										
SLC18A3	6572	broad.mit.edu	37	chr10	50819248	50819248	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcatgagctacgacgtgccGctgctgatcggcctgggcgt	15	13	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:50819248G>A	uc001jhw.2	+	1	902	c.462G>A	c.(460-462)CCG>CCA	p.P154P	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	154	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						ACGACGTGCCGCTGCTGATCG	0.637													0	0	0	1	0	45	150										A	50819248	G	A	50819248	2	1	18	1	0	0	0	0	0	0	0	1	14427	1074	38	2		2	SLC18A3	10	50819248	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	137015	50819248	84715499	293	4867										
OGDHL	55753	broad.mit.edu	37	chr10	50955190	50955190	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccagcgacagagtgatgttcCggttggtgacgcggttgatc	15	9	0	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:50955190C>T	uc001jie.2	-	9	1194	c.1052G>A	c.(1051-1053)CGG>CAG	p.R351Q	OGDHL_uc009xog.2_Missense_Mutation_p.R378Q|OGDHL_uc010qgt.1_Missense_Mutation_p.R294Q|OGDHL_uc010qgu.1_Missense_Mutation_p.R142Q|OGDHL_uc009xoh.2_Missense_Mutation_p.R142Q	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	351					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						AGTGATGTTCCGGTTGGTGAC	0.587													0	0	0	1	0	61	82										T	50955190	C	T	50955190	3	4	18	1	0	0	0	0	1	0	0	0	10840	652	23	2	2040	2	OGDHL	10	50955190	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	135942	50955190	84579557	294	4868										
PCDH15	65217	broad.mit.edu	37	chr10	55663071	55663071	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccgatgtagaattttttctGaaacactgggggatgattat	10	5	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:55663071G>C	uc001jju.1	-	26	3828	c.3433C>G	c.(3433-3435)CAG>GAG	p.Q1145E	PCDH15_uc010qhq.1_Missense_Mutation_p.Q1150E|PCDH15_uc010qhr.1_Missense_Mutation_p.Q1145E|PCDH15_uc010qhs.1_Missense_Mutation_p.Q1157E|PCDH15_uc010qht.1_Missense_Mutation_p.Q1152E|PCDH15_uc010qhu.1_Missense_Mutation_p.Q1145E|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.Q1145E|PCDH15_uc010qhw.1_Missense_Mutation_p.Q1108E|PCDH15_uc010qhx.1_Missense_Mutation_p.Q1074E|PCDH15_uc010qhy.1_Missense_Mutation_p.Q1150E|PCDH15_uc010qhz.1_Missense_Mutation_p.Q1145E|PCDH15_uc010qia.1_Missense_Mutation_p.Q1123E|PCDH15_uc010qib.1_Missense_Mutation_p.Q1123E	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1145	Cadherin 11.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AATTTTTTCTGAAACACTGGG	0.353										HNSCC(58;0.16)			0	0	0	1	0	35	38										C	55663071	G	C	55663071	3	2	18	1	0	0	0	0	1	0	0	0	11511	1299	45	1	4085	1	PCDH15	10	55663071	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4707881	55663071	79871676	295	4869										
HKDC1	80201	broad.mit.edu	37	chr10	71020971	71020971	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcgacctgaccaagcagggtCtcctcttccgagggcagatt	11	13	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:71020971C>G	uc001jpf.3	+	16	2426	c.2293C>G	c.(2293-2295)CTC>GTC	p.L765V	HKDC1_uc010qje.1_Missense_Mutation_p.L628V|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	765					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						CAAGCAGGGTCTCCTCTTCCG	0.517													0	0	0	1	0	41	54										G	71020971	C	G	71020971	3	3	18	1	0	0	0	0	1	0	0	0	7193	913	32	1	2355	1	HKDC1	10	71020971	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	15357900	71020971	64513776	296	4870										
CHCHD1	118487	broad.mit.edu	37	chr10	75542839	75542839	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttgtgttttcaggaagcccGaaagatgagatcaatacagg	11	6	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:75542839G>A	uc001jvc.3	+	3	277	c.251G>A	c.(250-252)CGA>CAA	p.R84Q	CHCHD1_uc001jvb.2_3'UTR|KIAA0913_uc009xrk.1_5'Flank|KIAA0913_uc001jve.2_5'Flank|KIAA0913_uc009xrl.2_5'Flank|KIAA0913_uc001jvf.2_5'Flank	NM_203298	NP_976043	Q96BP2	CHCH1_HUMAN	coiled-coil-helix-coiled-coil-helix domain	84						nucleus					0	Prostate(51;0.0112)					CAGGAAGCCCGAAAGATGAGA	0.378													0	0	0	1	0	58	71										A	75542839	G	A	75542839	3	1	18	1	0	0	0	0	1	0	0	0	3314	1058	37	1	261	1	CHCHD1	10	75542839	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4521868	75542839	59991908	297	4871										
IFIT2	3433	broad.mit.edu	37	chr10	91066854	91066854	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atctgcggtatggcaactttCagctgtaccaaatgaagtgt	10	8	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:91066854C>T	uc009xts.2	+	2	1316	c.1141C>T	c.(1141-1143)CAG>TAG	p.Q381*	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	381	TPR 6.				negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				TGGCAACTTTCAGCTGTACCA	0.403													0	0	0	1	0	74	41										T	91066854	C	T	91066854	4	4	18	1	0	0	0	0	0	1	0	0	7523	827	29	1	1147	1	IFIT2	10	91066854	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	15524015	91066854	44467893	298	4872										
C10orf129	142827	broad.mit.edu	37	chr10	96967005	96967005	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcccccagctgactgccaaGaaaattcgctatcaattacg	7	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:96967005G>C	uc001kke.2	+	4	569	c.444G>C	c.(442-444)AAG>AAC	p.K148N	C10orf129_uc009xuu.1_Missense_Mutation_p.K58N	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	acyl-coenzyme A synthetase ACSM6, mitochondrial	148					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGACTGCCAAGAAAATTCGCT	0.463													0	0	0	1	0	76	59										C	96967005	G	C	96967005	3	2	18	1	0	0	0	0	1	0	0	0	1593	933	33	1	454	1	C10orf129	10	96967005	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	5900151	96967005	38567742	299	4873										
PPRC1	23082	broad.mit.edu	37	chr10	103898696	103898696	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtgacctcatcaccccagttGacccactggggcccagtaca	9	16	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:103898696G>A	uc001kum.2	+	4	589	c.550G>A	c.(550-552)GAC>AAC	p.D184N	PPRC1_uc001kun.2_Missense_Mutation_p.D64N|PPRC1_uc010qqj.1_Missense_Mutation_p.D184N|PPRC1_uc009xxa.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CACCCCAGTTGACCCACTGGG	0.562													0	0	0	1	0	67	55										A	103898696	G	A	103898696	3	1	18	1	0	0	0	0	1	0	0	0	12410	1290	45	1	564	1	PPRC1	10	103898696	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6931691	103898696	31636051	300	4874										
PPRC1	23082	broad.mit.edu	37	chr10	103899460	103899460	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctacactggagtcagagacaGaggctgctgtgcccaaggta	13	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:103899460G>C	uc001kum.2	+	5	1234	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	PPRC1_uc001kun.2_Missense_Mutation_p.E279Q|PPRC1_uc010qqj.1_Missense_Mutation_p.E399Q|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTCAGAGACAGAGGCTGCTGT	0.562													0	0	0	1	0	137	152										C	103899460	G	C	103899460	3	2	18	1	0	0	0	0	1	0	0	0	12410	943	33	1	1213	1	PPRC1	10	103899460	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	764	103899460	31635287	301	4875										
SLK	9748	broad.mit.edu	37	chr10	105768064	105768064	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aacgcatcaaaggagaacaaGagaaagagttgtccaaattt	9	6	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:105768064G>C	uc001kxo.1	+	12	2768	c.2734G>C	c.(2734-2736)GAG>CAG	p.E912Q	SLK_uc001kxp.1_Missense_Mutation_p.E912Q	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	912	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity	p.E912*(1)		ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGGAGAACAAGAGAAAGAGTT	0.363													0	0	0	1	0	29	85										C	105768064	G	C	105768064	3	2	18	1	0	0	0	0	1	0	0	0	14748	943	33	1	2780	1	SLK	10	105768064	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1868604	105768064	29766683	302	4876										
SORCS1	114815	broad.mit.edu	37	chr10	108412274	108412274	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcagtgtactgttcccttaCgccatcagtgcaattattgg	10	10	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:108412274C>T	uc001kym.2	-	18	2349	c.2341G>A	c.(2341-2343)GTA>ATA	p.V781I	SORCS1_uc001kyl.2_Missense_Mutation_p.V781I|SORCS1_uc009xxs.2_Missense_Mutation_p.V781I|SORCS1_uc001kyn.1_Missense_Mutation_p.V781I|SORCS1_uc001kyo.2_Missense_Mutation_p.V781I	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	781	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGTTCCCTTACGCCATCAGTG	0.493													0	0	0	1	0	32	95										T	108412274	C	T	108412274	3	4	18	1	0	0	0	0	1	0	0	0	14930	536	19	2	1435	2	SORCS1	10	108412274	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2644210	108412274	27122473	303	4877										
DCLRE1A	9937	broad.mit.edu	37	chr10	115607068	115607068	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	accttcaaccacgccatactGaaaggcatcaactgtaaagc	6	13	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:115607068G>A	uc001law.2	-	3	3070	c.2152C>T	c.(2152-2154)CAG>TAG	p.Q718*		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	718					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		ACGCCATACTGAAAGGCATCA	0.378								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	1	0	47	53										A	115607068	G	A	115607068	4	1	18	1	0	0	0	0	0	1	0	0	4294	1299	45	1	998	1	DCLRE1A	10	115607068	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7194794	115607068	19927679	304	4878										
VWA2	340706	broad.mit.edu	37	chr10	116045895	116045895	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggtggcggtgcctgtggggGagtaccaggatgtgcctgac	19	8	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:116045895G>C	uc001lbl.1	+	11	1516	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	VWA2_uc001lbk.1_Missense_Mutation_p.E399Q|VWA2_uc009xyf.1_Missense_Mutation_p.E95Q	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	399	VWFA 2.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		GCCTGTGGGGGAGTACCAGGA	0.682													0	0	0	1	0	67	136										C	116045895	G	C	116045895	3	2	18	1	0	0	0	0	1	0	0	0	17236	1175	41	1	1233	1	VWA2	10	116045895	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	438827	116045895	19488852	305	4879										
ATRNL1	26033	broad.mit.edu	37	chr10	117045884	117045884	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagtagaatttgttctggatGaaatacagaagtatacacaa	8	4	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:117045884G>A	uc001lcg.2	+	15	2778	c.2392G>A	c.(2392-2394)GAA>AAA	p.E798K		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	798	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGTTCTGGATGAAATACAGAA	0.269													0	0	0	1	0	35	71										A	117045884	G	A	117045884	3	1	18	1	0	0	0	0	1	0	0	0	1207	1291	45	1	2450	1	ATRNL1	10	117045884	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	999989	117045884	18488863	306	4880										
ADAM12	8038	broad.mit.edu	37	chr10	127824155	127824155	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atggtcatggccacttacctGagaccagaacacgtgctgag	11	11	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:127824155G>A	uc001ljk.2	-	5	836	c.423C>T	c.(421-423)CTC>CTT	p.L141L	ADAM12_uc010qul.1_Silent_p.L138L|ADAM12_uc001ljm.2_Silent_p.L141L|ADAM12_uc001ljn.2_Silent_p.L138L|ADAM12_uc001ljl.3_Silent_p.L138L	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	141					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CCACTTACCTGAGACCAGAAC	0.512													0	0	0	1	0	32	67										A	127824155	G	A	127824155	2	1	18	1	0	0	0	0	0	0	0	1	236	1277	45	1		1	ADAM12	10	127824155	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10778271	127824155	7710592	307	4881										
C10orf90	118611	broad.mit.edu	37	chr10	128192934	128192934	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cattttggggctggcaatttGaggtggctcaatggggacgg	17	6	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:128192934G>C	uc001ljq.2	-	3	956	c.835C>G	c.(835-837)CAA>GAA	p.Q279E	C10orf90_uc001ljp.2_Missense_Mutation_p.Q232E|C10orf90_uc010qum.1_Missense_Mutation_p.Q376E|C10orf90_uc009yao.2_Missense_Mutation_p.Q376E|C10orf90_uc001ljs.1_Missense_Mutation_p.Q232E	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	279										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		CTGGCAATTTGAGGTGGCTCA	0.502											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	76	144										C	128192934	G	C	128192934	3	2	18	1	0	0	0	0	1	0	0	0	1623	1299	45	1	1292	1	C10orf90	10	128192934	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	368779	128192934	7341813	308	4882										
MKI67	4288	broad.mit.edu	37	chr10	129902126	129902126	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggccttctcctgctgggttCctcttctactgggtttggtt	11	11	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:129902126C>G	uc001lke.2	-	13	8173	c.7978G>C	c.(7978-7980)GAA>CAA	p.E2660Q	MKI67_uc001lkf.2_Missense_Mutation_p.E2300Q|MKI67_uc009yav.1_Missense_Mutation_p.E2235Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1810Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2660	14.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTGCTGGGTTCCTCTTCTACT	0.517													0	0	0	1	0	83	70										G	129902126	C	G	129902126	3	3	18	1	0	0	0	0	1	0	0	0	9598	864	30	1	1804	1	MKI67	10	129902126	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1709192	129902126	5632621	309	4883										
MKI67	4288	broad.mit.edu	37	chr10	129906114	129906114	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttaggagtttgtggccgtctCttgctgccggttaagttctc	12	9	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:129906114C>G	uc001lke.2	-	13	4185	c.3990G>C	c.(3988-3990)AAG>AAC	p.K1330N	MKI67_uc001lkf.2_Missense_Mutation_p.K970N|MKI67_uc009yav.1_Missense_Mutation_p.K905N|MKI67_uc009yaw.1_Missense_Mutation_p.K480N	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1330	16 X 122 AA approximate repeats.|3.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTGGCCGTCTCTTGCTGCCGG	0.502													0	0	0	1	0	123	124										G	129906114	C	G	129906114	3	3	18	1	0	0	0	0	1	0	0	0	9598	912	32	1	5792	1	MKI67	10	129906114	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3988	129906114	5628633	310	4884										
KNDC1	85442	broad.mit.edu	37	chr10	135003134	135003134	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggactccgtgctggttgctGaggacggggctgtgctcttc	16	10	1	1	rs143362573		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr10:135003134G>C	uc001llz.1	+	8	1475	c.1474G>C	c.(1474-1476)GAG>CAG	p.E492Q	KNDC1_uc001lma.1_Missense_Mutation_p.E427Q	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	492	KIND 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GCTGGTTGCTGAGGACGGGGC	0.672													0	0	0	1	0	31	25										C	135003134	G	C	135003134	3	2	18	1	0	0	0	0	1	0	0	0	8426	1291	45	1	1504	1	KNDC1	10	135003134	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	5097020	135003134	531613	311	4885										
OR52I1	390037	broad.mit.edu	37	chr11	4615695	4615695	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acaagagaattctcacgcctCaagtgatgctgggaatgagt	11	8	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:4615695C>G	uc010qyi.1	+	1	427	c.427C>G	c.(427-429)CAA>GAA	p.Q143E		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	143	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCACGCCTCAAGTGATGCT	0.507													0	0	0	1	0	53	10										G	4615695	C	G	4615695	3	3	18	1	0	0	0	0	1	0	0	0	11120	827	29	1	429	1	OR52I1	11	4615695	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		4615695	130390821	312	4886										
OR52A4	390053	broad.mit.edu	37	chr11	5142104	5142104	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	accttaagtcgtgcctctttCagaggcaagtgaaagacagt	10	9	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:5142104C>T	uc001lzz.1	-	1	705	c.705G>A	c.(703-705)CTG>CTA	p.L235L		NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GTGCCTCTTTCAGAGGCAAGT	0.358													0	0	0	1	0	43	5										T	5142104	C	T	5142104	2	4	18	1	0	0	0	0	0	0	0	1	11109	813	29	1		1	OR52A4	11	5142104	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	526409	5142104	129864412	313	4887										
IPO7	10527	broad.mit.edu	37	chr11	9455272	9455272	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tagtattctcttttagaattCtatgaggagatcttctcttt	6	6	4	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:9455272C>G	uc001mho.2	+	18	2095	c.1953C>G	c.(1951-1953)TTC>TTG	p.F651L		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	651					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTTTAGAATTCTATGAGGAGA	0.383													0	0	0	1	0	59	6										G	9455272	C	G	9455272	3	3	18	1	0	0	0	0	1	0	0	0	7797	912	32	1	2023	1	IPO7	11	9455272	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	4313168	9455272	125551244	314	4888										
EIF3M	10480	broad.mit.edu	37	chr11	32610646	32610646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttaaagtggcagcatcttgtGgggccatccagtacatccca	10	11	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:32610646G>A	uc001mtu.2	+	4	446	c.403G>A	c.(403-405)GGG>AGG	p.G135R	EIF3M_uc010ref.1_Intron	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	135						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					AGCATCTTGTGGGGCCATCCA	0.383													0	0	0	1	0	33	80										A	32610646	G	A	32610646	3	1	18	1	0	0	0	0	1	0	0	0	5023	1348	47	2	417	2	EIF3M	11	32610646	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	23155374	32610646	102395870	315	4889										
FBXO3	26273	broad.mit.edu	37	chr11	33763508	33763508	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggaacatcaaagactctcctCcgtctctcctcttcatcatc	4	16	6	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:33763508C>G	uc001muz.2	-	11	1390	c.1362G>C	c.(1360-1362)CGG>CGC	p.R454R	FBXO3_uc010rej.1_Silent_p.R141R|FBXO3_uc001muy.2_Silent_p.R341R|FBXO3_uc009ykb.2_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	454	Poly-Arg.				proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AGACTCTCCTCCGTCTCTCCT	0.368													0	0	0	1	0	58	11										G	33763508	C	G	33763508	2	3	18	1	0	0	0	0	0	0	0	1	5739	842	30	1		1	FBXO3	11	33763508	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1152862	33763508	101243008	316	4890										
LRP4	4038	broad.mit.edu	37	chr11	46916251	46916251	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaagacaagctcgcggcggtGgtggaaatcaagggcaatgg	17	7	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:46916251G>A	uc001ndn.3	-	12	1575	c.1429C>T	c.(1429-1431)CAC>TAC	p.H477Y		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	477	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TCGCGGCGGTGGTGGAAATCA	0.582													0	0	0	1	0	81	9										A	46916251	G	A	46916251	3	1	18	1	0	0	0	0	1	0	0	0	8959	1348	47	2	4396	2	LRP4	11	46916251	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	13152743	46916251	88090265	317	4891										
SLC43A1	8501	broad.mit.edu	37	chr11	57256845	57256845	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgcagtagcgtggtctgatgGatttggtagcaaccccgtcc	13	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:57256845G>C	uc001nkk.2	-	12	1332	c.1214C>G	c.(1213-1215)TCC>TGC	p.S405C	SLC43A1_uc001nkl.2_Missense_Mutation_p.S405C	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	405					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						TGGTCTGATGGATTTGGTAGC	0.577													0	0	0	1	0	44	130										C	57256845	G	C	57256845	3	2	18	1	0	0	0	0	1	0	0	0	14632	1174	41	1	481	1	SLC43A1	11	57256845	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10340594	57256845	77749671	318	4892										
ASRGL1	80150	broad.mit.edu	37	chr11	62159721	62159721	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcaagctgcacttcggaattGatcctgacgatactactatc	8	11	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62159721G>C	uc001nte.3	+	7	1176	c.892G>C	c.(892-894)GAT>CAT	p.D298H	ASRGL1_uc001ntf.3_Missense_Mutation_p.D298H|ASRGL1_uc001ntg.3_Missense_Mutation_p.D170H	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	298					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	CTTCGGAATTGATCCTGACGA	0.527											OREG0021023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	29	60										C	62159721	G	C	62159721	3	2	18	1	0	0	0	0	1	0	0	0	1060	1290	45	1	914	1	ASRGL1	11	62159721	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4902876	62159721	72846795	319	4893										
INTS5	80789	broad.mit.edu	37	chr11	62414897	62414897	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaggcttcccaatggcccaaGagggcggccagcagcccccg	14	16	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62414897G>A	uc001nud.2	-	2	2708	c.2655C>T	c.(2653-2655)CTC>CTT	p.L885L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	885					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AATGGCCCAAGAGGGCGGCCA	0.642													0	0	0	1	0	32	72										A	62414897	G	A	62414897	2	1	18	1	0	0	0	0	0	0	0	1	7781	929	33	1		1	INTS5	11	62414897	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	255176	62414897	72591619	320	4894										
INTS5	80789	broad.mit.edu	37	chr11	62416485	62416485	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcaatccacaagctctccaGagacagtgcccagcaaagct	9	14	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62416485G>C	uc001nud.2	-	2	1120	c.1067C>G	c.(1066-1068)TCT>TGT	p.S356C	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	356					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AAGCTCTCCAGAGACAGTGCC	0.607													0	0	0	1	0	43	96										C	62416485	G	C	62416485	3	2	18	1	0	0	0	0	1	0	0	0	7781	942	33	1	1996	1	INTS5	11	62416485	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1588	62416485	72590031	321	4895										
METTL12	751071	broad.mit.edu	37	chr11	62434355	62434355	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagcttctatcagaatgcttGagggttctaaaccctcaggg	10	10	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:62434355G>T	uc001nug.1	+	3	814	c.555G>T	c.(553-555)TTG>TTT	p.L185F	C11orf48_uc001nue.2_Intron|C11orf48_uc001nuf.2_Intron|METTL12_uc001nuh.2_3'UTR|METTL12_uc010rmc.1_RNA	NM_001043229	NP_001036694	A8MUP2	MTL12_HUMAN	methyltransferase like 12 precursor	185						mitochondrion	methyltransferase activity				0						CAGAATGCTTGAGGGTTCTAA	0.547													1	0	5.26018e-13	1	5.41022e-13	21	28										T	62434355	G	T	62434355	3	4	18	1	0	0	0	0	1	0	0	0	9496	1281	45	3	561	3	METTL12	11	62434355	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	17870	62434355	72572161	322	4896										
FKBP2	2286	broad.mit.edu	37	chr11	64011466	64011466	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caaccctggtgttcgaggtgGagctgctcaaaatagagcga	13	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:64011466G>C	uc001nyy.2	+	6	590	c.394G>C	c.(394-396)GAG>CAG	p.E132Q	FKBP2_uc010rnh.1_Missense_Mutation_p.E132Q|FKBP2_uc001nyz.2_Missense_Mutation_p.E132Q	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	132	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						GTTCGAGGTGGAGCTGCTCAA	0.572													0	0	0	1	0	52	118										C	64011466	G	C	64011466	3	2	18	1	0	0	0	0	1	0	0	0	5908	1175	41	1	412	1	FKBP2	11	64011466	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1577111	64011466	70995050	323	4897										
GPR137	56834	broad.mit.edu	37	chr11	64054470	64054470	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccaaggtgaagcgtcggccgGagatgagccgaggcttgtaa	16	9	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:64054470G>C	uc001nzg.1	+	3	699	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Missense_Mutation_p.E137Q|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Missense_Mutation_p.E189Q|GPR137_uc001nze.1_Missense_Mutation_p.E131Q|GPR137_uc001nzf.2_Missense_Mutation_p.E131Q|GPR137_uc001nzh.1_Missense_Mutation_p.E131Q|GPR137_uc001nzi.2_Missense_Mutation_p.E131Q|GPR137_uc010rnj.1_Missense_Mutation_p.E131Q	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	131	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						GCGTCGGCCGGAGATGAGCCG	0.572													0	0	0	1	0	10	22										C	64054470	G	C	64054470	3	2	18	1	0	0	0	0	1	0	0	0	6645	1175	41	1	579	1	GPR137	11	64054470	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	43004	64054470	70952046	324	4898										
ATG2A	23130	broad.mit.edu	37	chr11	64662883	64662883	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggagacgggggctgccgggGacaggatgtcatacacggtc	19	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:64662883G>T	uc001obx.2	-	40	5574	c.5459C>A	c.(5458-5460)TCC>TAC	p.S1820Y	uc009ypx.2_5'Flank|ATG2A_uc001obw.2_Missense_Mutation_p.S585Y	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1820							protein binding			ovary(1)|central_nervous_system(1)	2						GGCTGCCGGGGACAGGATGTC	0.701													1	0	1.26484e-09	1	1.28796e-09	7	9										T	64662883	G	T	64662883	3	4	18	1	0	0	0	0	1	0	0	0	1093	1174	41	3	365	3	ATG2A	11	64662883	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	608413	64662883	70343633	325	4899										
PACS1	55690	broad.mit.edu	37	chr11	65961019	65961019	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatggacaaagatcttaactCagtggtcatcgctgtgaagc	10	8	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:65961019C>G	uc001oha.1	+	2	553	c.419C>G	c.(418-420)TCA>TGA	p.S140*	PACS1_uc001ogz.1_Nonsense_Mutation_p.S140*	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	140					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						GATCTTAACTCAGTGGTCATC	0.488													0	0	0	1	0	21	96										G	65961019	C	G	65961019	4	3	18	1	0	0	0	0	0	1	0	0	11372	838	29	1	425	1	PACS1	11	65961019	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1298136	65961019	69045497	326	4900										
GPR152	390212	broad.mit.edu	37	chr11	67220174	67220174	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtggccagtggcacccaggtCagcttccatggtagtgtcca	13	12	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:67220174C>T	uc001olm.2	-	1	27	c.22G>A	c.(22-24)GAC>AAC	p.D8N	uc009yrw.1_Intron|CABP4_uc001oln.2_Intron|CABP4_uc001olo.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	8	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GCACCCAGGTCAGCTTCCATG	0.602													0	0	0	1	0	59	36										T	67220174	C	T	67220174	3	4	18	1	0	0	0	0	1	0	0	0	6658	826	29	1	1394	1	GPR152	11	67220174	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1259155	67220174	67786342	327	4901										
UNC93B1	81622	broad.mit.edu	37	chr11	67759316	67759316	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caccagcgtcaccagcagcaCcgccagcttagcctgggcgt	11	17	1	0	rs4014596		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:67759316C>T	uc001omw.1	-	12	1575	c.1495G>A	c.(1495-1497)GTG>ATG	p.V499M		NM_030930	NP_112192	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1	499	Helical; (Potential).				innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome					0						ACCAGCAGCACCGCCAGCTTA	0.741													0	0	0	1	0	3	28										T	67759316	C	T	67759316	3	4	18	1	0	0	0	0	1	0	0	0	16994	507	18	2	302	2	UNC93B1	11	67759316	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	539142	67759316	67247200	328	4902										
SUV420H1	51111	broad.mit.edu	37	chr11	67957499	67957499	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gacaacttgcctccatttctCctgccattcaccaccatgat	4	16	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:67957499C>G	uc001onm.1	-	2	301	c.45G>C	c.(43-45)AGG>AGC	p.R15S	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_5'UTR|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.R15S|SUV420H1_uc001onp.2_Missense_Mutation_p.R15S|SUV420H1_uc010rqa.1_Missense_Mutation_p.R15S|SUV420H1_uc001onq.2_Missense_Mutation_p.R15S	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CTCCATTTCTCCTGCCATTCA	0.473													0	0	0	1	0	278	508										G	67957499	C	G	67957499	3	3	18	1	0	0	0	0	1	0	0	0	15411	854	30	1	2660	1	SUV420H1	11	67957499	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	198183	67957499	67049017	329	4903										
CTTN	2017	broad.mit.edu	37	chr11	70265929	70265929	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcgccgttggctttgagtatCaaggcaaaacggagaagcac	13	9	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:70265929C>G	uc001opv.3	+	9	852	c.646C>G	c.(646-648)CAA>GAA	p.Q216E	CTTN_uc001opu.2_Missense_Mutation_p.Q216E|CTTN_uc001opw.3_Missense_Mutation_p.Q216E|CTTN_uc010rqm.1_5'Flank|CTTN_uc001opx.2_5'Flank	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	216	Cortactin 4.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CTTTGAGTATCAAGGCAAAAC	0.473													0	0	0	1	0	137	35										G	70265929	C	G	70265929	3	3	18	1	0	0	0	0	1	0	0	0	4044	827	29	1	672	1	CTTN	11	70265929	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2308430	70265929	64740587	330	4904										
RAB38	23682	broad.mit.edu	37	chr11	87908415	87908415	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagtggagcaccttgagcgcGaagtccacgccgattgtggc	14	12	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:87908415G>C	uc001pcj.1	-	1	185	c.138C>G	c.(136-138)TTC>TTG	p.F46L	hsa-mir-3166|MI0014196_5'Flank	NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	46	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCTTGAGCGCGAAGTCCACGC	0.637													0	0	0	1	0	32	9										C	87908415	G	C	87908415	3	2	18	1	0	0	0	0	1	0	0	0	12928	1049	37	1	509	1	RAB38	11	87908415	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	17642486	87908415	47098101	331	4905										
ATM	472	broad.mit.edu	37	chr11	108106537	108106537	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgtgagaaaatactggtgtGaaatatctcagcaacagtgg	11	6	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:108106537G>C	uc001pkb.1	+	5	857	c.472G>C	c.(472-474)GAA>CAA	p.E158Q	ATM_uc009yxr.1_Missense_Mutation_p.E158Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	158					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATACTGGTGTGAAATATCTCA	0.363			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	1	0	64	21										C	108106537	G	C	108106537	3	2	18	1	0	0	0	0	1	0	0	0	1109	1291	45	1	486	1	ATM	11	108106537	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	20198122	108106537	26899979	332	4906										
POU2AF1	5450	broad.mit.edu	37	chr11	111225125	111225125	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaaggactggctctgggataGagatggggagctggacaaac	17	6	1	1	rs149278202		TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:111225125G>C	uc001plg.3	-	5	887	c.632C>G	c.(631-633)TCT>TGT	p.S211C		NM_006235	NP_006226	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	211					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			kidney(1)	1		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		CTCTGGGATAGAGATGGGGAG	0.622			T	BCL6	NHL								0	0	0	1	0	35	12										C	111225125	G	C	111225125	3	2	18	1	0	0	0	0	1	0	0	0	12270	942	33	1	142	1	POU2AF1	11	111225125	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3118588	111225125	23781391	333	4907										
FDXACB1	91893	broad.mit.edu	37	chr11	111747287	111747287	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatcctgaagattctgggttGagaaccttcaaaaggtaagc	11	7	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:111747287G>C	uc001pmc.3	-	4	907	c.610C>G	c.(610-612)CAA>GAA	p.Q204E	ALG9_uc010rwo.1_5'UTR|FDXACB1_uc009yyi.2_Missense_Mutation_p.Q55E|C11orf1_uc001pmd.2_5'Flank	NM_138378	NP_612387	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain	204					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0						ATTCTGGGTTGAGAACCTTCA	0.413													0	0	0	1	0	52	19										C	111747287	G	C	111747287	3	2	18	1	0	0	0	0	1	0	0	0	5806	1299	45	1	1272	1	FDXACB1	11	111747287	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	522162	111747287	23259229	334	4908										
TTC36	143941	broad.mit.edu	37	chr11	118399332	118399332	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcccagatgaagttttccctCaagcacagctggaacagtcc	9	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:118399332C>G	uc001ptg.1	+	2	133	c.133C>G	c.(133-135)CAA>GAA	p.Q45E	TTC36_uc010ryb.1_RNA|TTC36_uc010ryc.1_Intron|TMEM25_uc010ryd.1_5'Flank|TMEM25_uc001ptk.3_5'Flank|TMEM25_uc010rye.1_5'Flank|TMEM25_uc001pth.2_5'Flank|TMEM25_uc009zad.2_5'Flank|TMEM25_uc001pti.2_5'Flank|TMEM25_uc010ryf.1_5'Flank|TMEM25_uc001ptl.2_5'Flank|TMEM25_uc001ptm.2_5'Flank	NM_001080441	NP_001073910	A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	45							binding				0						AGTTTTCCCTCAAGCACAGCT	0.572													0	0	0	1	0	56	10										G	118399332	C	G	118399332	3	3	18	1	0	0	0	0	1	0	0	0	16701	827	29	1	139	1	TTC36	11	118399332	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6652045	118399332	16607184	335	4909										
GLB1L3	112937	broad.mit.edu	37	chr11	134183857	134183857	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ataactggatctgtcagcatCaataactcttccctggaggg	9	10	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr11:134183857C>T	uc009zdf.2	+	17	1962	c.1602C>T	c.(1600-1602)ATC>ATT	p.I534I	GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	534					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CTGTCAGCATCAATAACTCTT	0.483													0	0	0	1	0	27	6										T	134183857	C	T	134183857	2	4	18	1	0	0	0	0	0	0	0	1	6430	816	29	1		1	GLB1L3	11	134183857	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	15784525	134183857	822659	336	4910										
AKAP3	10566	broad.mit.edu	37	chr12	4724985	4724985	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	attcagctggcgctccttctCatagcgcagcaccgactgca	9	15	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:4724985C>T	uc001qnb.3	-	5	2711	c.2482G>A	c.(2482-2484)GAG>AAG	p.E828K		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	828					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						CGCTCCTTCTCATAGCGCAGC	0.562													0	0	0	1	0	101	142										T	4724985	C	T	4724985	3	4	18	1	0	0	0	0	1	0	0	0	452	835	29	1	83	1	AKAP3	12	4724985	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		4724985	129126910	337	4911										
KCNA5	3741	broad.mit.edu	37	chr12	5155043	5155043	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggagaatgcagacagtgcccGaaggggcagctgccccctag	15	12	0	2	rs139805781	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:5155043G>A	uc001qni.2	+	1	1959	c.1730G>A	c.(1729-1731)CGA>CAA	p.R577Q		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	577						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GACAGTGCCCGAAGGGGCAGC	0.642													0	0	0	1	0	25	33										A	5155043	G	A	5155043	3	1	18	1	0	0	0	0	1	0	0	0	8006	1058	37	1	1732	1	KCNA5	12	5155043	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	430058	5155043	128696852	338	4912										
PHC1	1911	broad.mit.edu	37	chr12	9074235	9074235	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcggccgcccagctcatcagCcgatcccagagtgtgagctc	11	16	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:9074235C>G	uc001qvd.2	+	5	501	c.345C>G	c.(343-345)AGC>AGG	p.S115R	PHC1_uc001qvc.1_Missense_Mutation_p.S78R|PHC1_uc010sgn.1_Missense_Mutation_p.S115R|PHC1_uc001qve.2_Missense_Mutation_p.S115R	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	115					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						AGCTCATCAGCCGATCCCAGA	0.557													0	0	0	1	0	28	29										G	9074235	C	G	9074235	3	3	18	1	0	0	0	0	1	0	0	0	11816	738	26	4	359	4	PHC1	12	9074235	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3919192	9074235	124777660	339	4913										
PZP	5858	broad.mit.edu	37	chr12	9303317	9303317	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgtcttgcagaaccatgaagGaaaaacttagcgtctgattt	9	7	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:9303317G>A	uc001qvl.2	-	34	4336	c.4307C>T	c.(4306-4308)TCC>TTC	p.S1436F	PZP_uc009zgl.2_Missense_Mutation_p.S1222F	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AACCATGAAGGAAAAACTTAG	0.383													0	0	0	1	0	34	41										A	9303317	G	A	9303317	3	1	18	1	0	0	0	0	1	0	0	0	12869	1174	41	1	153	1	PZP	12	9303317	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	229082	9303317	124548578	340	4914										
PRR4	11272	broad.mit.edu	37	chr12	10999683	10999683	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	taccagagtggttgctcctgGggatgtcttgctggtctgtc	14	9	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:10999683G>A	uc001qyz.3	-	3	423	c.384C>T	c.(382-384)CCC>CCT	p.P128P	PRR4_uc009zhp.2_Silent_p.P141P|PRH1_uc001qzb.3_RNA|PRR4_uc001qza.3_RNA	NM_007244	NP_009175	Q16378	PROL4_HUMAN	proline rich 4 (lacrimal) isoform 2	128					visual perception	extracellular space					0						GTTGCTCCTGGGGATGTCTTG	0.463													0	0	0	1	0	70	82										A	10999683	G	A	10999683	2	1	18	1	0	0	0	0	0	0	0	1	12599	1219	43	2		2	PRR4	12	10999683	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1696366	10999683	122852212	341	4915										
TAS2R50	259296	broad.mit.edu	37	chr12	11138715	11138715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagcctcctaggactccaaaCcgaaacgattaggaatagaa	8	11	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:11138715C>T	uc001qzl.2	-	1	797	c.745G>A	c.(745-747)GTT>ATT	p.V249I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	249	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						GGACTCCAAACCGAAACGATT	0.438													0	0	0	1	0	40	58										T	11138715	C	T	11138715	3	4	18	1	0	0	0	0	1	0	0	0	15581	507	18	2	158	2	TAS2R50	12	11138715	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	139032	11138715	122713180	342	4916										
CDKN1B	1027	broad.mit.edu	37	chr12	12870793	12870793	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatgtcaaacgtgcgagtgtCtaacgggagccctagcctgg	14	10	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:12870793C>G	uc001rat.2	+	1	492	c.20C>G	c.(19-21)TCT>TGT	p.S7C		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	7					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		GTGCGAGTGTCTAACGGGAGC	0.612									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				0	0	0	1	0	61	85										G	12870793	C	G	12870793	3	3	18	1	0	0	0	0	1	0	0	0	3159	913	32	1	22	1	CDKN1B	12	12870793	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1732078	12870793	120981102	343	4917										
CDKN1B	1027	broad.mit.edu	37	chr12	12871765	12871765	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcccctgcgcttagattcttCtactcaaaacaaaagagcca	5	13	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:12871765C>G	uc001rat.2	+	2	954	c.482C>G	c.(481-483)TCT>TGT	p.S161C		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	161	Nuclear localization signal (Potential).			S->A: No change in PKB/AKT1-mediated phosphorylation.	autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		TTAGATTCTTCTACTCAAAAC	0.438									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				0	0	0	1	0	77	95										G	12871765	C	G	12871765	3	3	18	1	0	0	0	0	1	0	0	0	3159	913	32	1	488	1	CDKN1B	12	12871765	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	972	12871765	120980130	344	4918										
SOX5	6660	broad.mit.edu	37	chr12	23728769	23728769	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gttcagtggctgtgccacttCatcctgcaatgatcattaga	9	10	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:23728769C>T	uc001rfw.2	-	10	1270	c.1168G>A	c.(1168-1170)GAA>AAA	p.E390K	SOX5_uc001rfx.2_Missense_Mutation_p.E377K|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Missense_Mutation_p.E4K|SOX5_uc010siv.1_Missense_Mutation_p.E377K|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E342K	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	390					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TGTGCCACTTCATCCTGCAAT	0.443													0	0	0	1	0	40	52										T	23728769	C	T	23728769	3	4	18	1	0	0	0	0	1	0	0	0	14954	835	29	1	1147	1	SOX5	12	23728769	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10857004	23728769	110123126	345	4919										
SOX5	6660	broad.mit.edu	37	chr12	23998926	23998926	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccagcctttaccttccggctCgtttttgatgagctcttcca	7	14	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:23998926C>G	uc001rfw.2	-	3	574	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	SOX5_uc001rfx.2_Missense_Mutation_p.E145Q|SOX5_uc001rfy.2_Missense_Mutation_p.E145Q|SOX5_uc010siv.1_Missense_Mutation_p.E145Q|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E110Q|SOX5_uc001rga.2_Missense_Mutation_p.E123Q	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	158					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						CCTTCCGGCTCGTTTTTGATG	0.408													0	0	0	1	0	32	62										G	23998926	C	G	23998926	3	3	18	1	0	0	0	0	1	0	0	0	14954	893	31	1	1881	1	SOX5	12	23998926	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	270157	23998926	109852969	346	4920										
PRPF40B	25766	broad.mit.edu	37	chr12	50029643	50029643	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	taggaacaggccaagcagctCcggcgccgcaatatccaggc	12	14	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:50029643C>T	uc001rur.1	+	14	1291	c.1227C>T	c.(1225-1227)CTC>CTT	p.L409L	PRPF40B_uc001rup.1_Silent_p.L431L|PRPF40B_uc001ruq.1_Silent_p.L403L|PRPF40B_uc001rus.1_Silent_p.L352L	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	409					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CCAAGCAGCTCCGGCGCCGCA	0.602													0	0	0	1	0	43	44										T	50029643	C	T	50029643	2	4	18	1	0	0	0	0	0	0	0	1	12572	842	30	1		1	PRPF40B	12	50029643	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	26030717	50029643	83822252	347	4921										
SCN8A	6334	broad.mit.edu	37	chr12	52100287	52100287	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagaaggagggggctcccctCggagctcttctgaaatctct	12	11	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:52100287C>T	uc001ryw.2	+	11	1601	c.1423C>T	c.(1423-1425)CGG>TGG	p.R475W	SCN8A_uc010snl.1_Missense_Mutation_p.R340W|SCN8A_uc001ryx.1_Missense_Mutation_p.R340W|SCN8A_uc001ryz.1_Missense_Mutation_p.R340W|SCN8A_uc001ryy.2_Missense_Mutation_p.R340W	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	475					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGGCTCCCCTCGGAGCTCTTC	0.502													0	0	0	1	0	12	10										T	52100287	C	T	52100287	3	4	18	1	0	0	0	0	1	0	0	0	13924	875	31	1	1461	1	SCN8A	12	52100287	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2070644	52100287	81751608	348	4922										
EIF4B	1975	broad.mit.edu	37	chr12	53412671	53412671	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccactgctccacgggctgctCgggaacccaatatcgaccgg	11	16	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:53412671C>A	uc001sbh.3	+	3	447	c.241C>A	c.(241-243)CGG>AGG	p.R81R	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Silent_p.R81R|EIF4B_uc010snv.1_Silent_p.R81R|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	81					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						ACGGGCTGCTCGGGAACCCAA	0.512													1	0	6.09941e-20	1	6.34794e-20	52	113										A	53412671	C	A	53412671	2	1	18	1	0	0	0	0	0	0	0	1	5027	875	31	3		3	EIF4B	12	53412671	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1312384	53412671	80439224	349	4923										
SMARCC2	6601	broad.mit.edu	37	chr12	56575311	56575311	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttctggggttggtgaaggaGagggggagcgcttcctcttc	17	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:56575311G>C	uc001skb.2	-	10	1017	c.911C>G	c.(910-912)TCT>TGT	p.S304C	SMARCC2_uc001skd.2_Missense_Mutation_p.S304C|SMARCC2_uc001ska.2_Missense_Mutation_p.S304C|SMARCC2_uc001skc.2_Missense_Mutation_p.S304C|SMARCC2_uc010sqf.1_Missense_Mutation_p.S193C	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	304					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGTGAAGGAGAGGGGGAGCG	0.507													0	0	0	1	0	29	45										C	56575311	G	C	56575311	3	2	18	1	0	0	0	0	1	0	0	0	14776	942	33	1	2906	1	SMARCC2	12	56575311	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	3162640	56575311	77276584	350	4924										
BAZ2A	11176	broad.mit.edu	37	chr12	56996518	56996518	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	taagttcccctctgttccttCtacaaagataccagccaaat	4	13	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:56996518C>A	uc001slq.1	-	19	3603	c.3409G>T	c.(3409-3411)GAA>TAA	p.E1137*	BAZ2A_uc001slp.1_Nonsense_Mutation_p.E1135*|BAZ2A_uc001slo.1_5'Flank|BAZ2A_uc009zov.1_Nonsense_Mutation_p.E107*|BAZ2A_uc009zow.1_Nonsense_Mutation_p.E1105*	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1137					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TCTGTTCCTTCTACAAAGATA	0.493													1	0	3.6726e-16	1	3.79647e-16	20	33										A	56996518	C	A	56996518	4	1	18	1	0	0	0	0	0	1	0	0	1331	922	32	3	2352	3	BAZ2A	12	56996518	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	421207	56996518	76855377	351	4925										
SRGAP1	57522	broad.mit.edu	37	chr12	64472798	64472798	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccagcacagtcgttccacaGaatcagtgaagtccactgtc	8	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:64472798G>C	uc010ssp.1	+	9	1281	c.1225G>C	c.(1225-1227)GAA>CAA	p.E409Q	SRGAP1_uc001srt.2_Missense_Mutation_p.E409Q|SRGAP1_uc001srv.2_Missense_Mutation_p.E369Q	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	409					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TCGTTCCACAGAATCAGTGAA	0.468													0	0	0	1	0	37	44										C	64472798	G	C	64472798	3	2	18	1	0	0	0	0	1	0	0	0	15144	943	33	1	1259	1	SRGAP1	12	64472798	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7476280	64472798	69379097	352	4926										
ZDHHC17	23390	broad.mit.edu	37	chr12	77239552	77239552	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctgtatagcaaaatttgatCatcattgcccatgggtgggt	11	7	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:77239552C>T	uc001syk.1	+	13	1556	c.1393C>T	c.(1393-1395)CAT>TAT	p.H465Y		NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	465	Cytoplasmic (Potential).|DHHC-type.				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						AAAATTTGATCATCATTGCCC	0.348													0	0	0	1	0	102	113										T	77239552	C	T	77239552	3	4	18	1	0	0	0	0	1	0	0	0	17604	826	29	1	1443	1	ZDHHC17	12	77239552	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	12766754	77239552	56612343	353	4927										
SLC6A15	55117	broad.mit.edu	37	chr12	85285836	85285836	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtcttcattggaaagaaggtCtttgacagactcagtaacat	9	7	4	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:85285836C>G	uc001szv.2	-	2	557	c.64G>C	c.(64-66)GAC>CAC	p.D22H	SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.D22H	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	22	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						GAAAGAAGGTCTTTGACAGAC	0.353													0	0	0	1	0	79	113										G	85285836	C	G	85285836	3	3	18	1	0	0	0	0	1	0	0	0	14678	913	32	1	2286	1	SLC6A15	12	85285836	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	8046284	85285836	48566059	354	4928										
AMDHD1	144193	broad.mit.edu	37	chr12	96354209	96354209	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	actgaagctgctgatgacatCatcaataaccacctcccaaa	5	13	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:96354209C>T	uc001tel.1	+	5	727	c.621C>T	c.(619-621)ATC>ATT	p.I207I	AMDHD1_uc009zth.1_Silent_p.I98I	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	207					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						CTGATGACATCATCAATAACC	0.403													0	0	0	1	0	17	38										T	96354209	C	T	96354209	2	4	18	1	0	0	0	0	0	0	0	1	567	816	29	1		1	AMDHD1	12	96354209	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	11068373	96354209	37497686	355	4929										
TXNRD1	7296	broad.mit.edu	37	chr12	104609593	104609593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgtgcgacatgggctgcgccGagggcaaggcagtggcggcg	20	10	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:104609593G>A	uc010swk.1	+	1	35	c.13G>A	c.(13-15)GAG>AAG	p.E5K	TXNRD1_uc001tkm.1_Intron	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	5					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GGGCTGCGCCGAGGGCAAGGC	0.721											OREG0022069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	2										A	104609593	G	A	104609593	3	1	18	1	0	0	0	0	1	0	0	0	16804	1059	37	1	15	1	TXNRD1	12	104609593	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	8255384	104609593	29242302	356	4930										
NUAK1	9891	broad.mit.edu	37	chr12	106461446	106461446	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agactgagcaaagtcattctCtttcttggatttcttcagcg	8	9	5	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:106461446C>G	uc001tlj.1	-	7	2500	c.1120G>C	c.(1120-1122)GAG>CAG	p.E374Q		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	374							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						AAGTCATTCTCTTTCTTGGAT	0.542													0	0	0	1	0	42	58										G	106461446	C	G	106461446	3	3	18	1	0	0	0	0	1	0	0	0	10712	922	32	1	869	1	NUAK1	12	106461446	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1851853	106461446	27390449	357	4931										
ATXN2	6311	broad.mit.edu	37	chr12	111926344	111926344	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acatgctgggctggaagtctGaaccccttgggaagtgacct	13	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:111926344G>C	uc001tsj.2	-	15	2818	c.2656C>G	c.(2656-2658)CAG>GAG	p.Q886E	ATXN2_uc001tsh.2_Missense_Mutation_p.Q621E|ATXN2_uc001tsi.2_Missense_Mutation_p.Q597E|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.Q72E	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	886					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CTGGAAGTCTGAACCCCTTGG	0.498													0	0	0	1	0	33	64										C	111926344	G	C	111926344	3	2	18	1	0	0	0	0	1	0	0	0	1211	1299	45	1	1329	1	ATXN2	12	111926344	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	5464898	111926344	21925551	358	4932										
NAA25	80018	broad.mit.edu	37	chr12	112530905	112530905	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caacagtttatctgcttgctGaattgccattttattattac	5	8	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:112530905G>A	uc001ttm.2	-	2	114	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.Q4*|NAA25_uc009zwa.1_Nonsense_Mutation_p.Q32*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	32	TPR 1.					cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TCTGCTTGCTGAATTGCCATT	0.308													0	0	0	1	0	54	70										A	112530905	G	A	112530905	4	1	18	1	0	0	0	0	0	1	0	0	10121	1299	45	1	2916	1	NAA25	12	112530905	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	604561	112530905	21320990	359	4933										
TBX5	6910	broad.mit.edu	37	chr12	114793425	114793425	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagtccttggcacgccatgaGagtagaggaactcagggggc	16	9	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:114793425G>C	uc001tvo.2	-	9	1964	c.1469C>G	c.(1468-1470)TCT>TGT	p.S490C	TBX5_uc001tvp.2_Missense_Mutation_p.S490C|TBX5_uc001tvq.2_Missense_Mutation_p.S440C	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	490					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CACGCCATGAGAGTAGAGGAA	0.612													0	0	0	1	0	20	48										C	114793425	G	C	114793425	3	2	18	1	0	0	0	0	1	0	0	0	15658	942	33	1	91	1	TBX5	12	114793425	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2262520	114793425	19058470	360	4934										
FBXO21	23014	broad.mit.edu	37	chr12	117583954	117583954	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caccgtttcatagacaaactCcagatcttctggataccgga	7	12	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:117583954C>G	uc001twk.2	-	12	1864	c.1825G>C	c.(1825-1827)GAG>CAG	p.E609Q	FBXO21_uc001twj.2_Missense_Mutation_p.E602Q|FBXO21_uc009zwq.2_Missense_Mutation_p.E542Q	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	609					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		TAGACAAACTCCAGATCTTCT	0.453													0	0	0	1	0	48	86										G	117583954	C	G	117583954	3	3	18	1	0	0	0	0	1	0	0	0	5733	864	30	1	65	1	FBXO21	12	117583954	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2790529	117583954	16267941	361	4935										
GCN1L1	10985	broad.mit.edu	37	chr12	120575576	120575576	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gatgatccggtgccctgtgtCatcctctacggagaggatca	12	11	3	2	rs146550123	by1000genomes	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:120575576C>T	uc001txo.2	-	49	6449	c.6436G>A	c.(6436-6438)GAC>AAC	p.D2146N		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2146					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCCCTGTGTCATCCTCTACG	0.582													0	0	0	1	0	23	21										T	120575576	C	T	120575576	3	4	18	1	0	0	0	0	1	0	0	0	6299	826	29	1	1619	1	GCN1L1	12	120575576	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2991622	120575576	13276319	362	4936										
HNF1A	6927	broad.mit.edu	37	chr12	121426650	121426650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcccagggaggacccgtggcGtgtggcgaagatggtcaagt	17	9	1	1	rs139016696	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:121426650G>A	uc001tzg.2	+	2	364	c.341G>A	c.(340-342)CGT>CAT	p.R114H	HNF1A_uc001tze.1_Missense_Mutation_p.R114H|HNF1A_uc001tzf.2_Missense_Mutation_p.R114H|HNF1A_uc010szn.1_Missense_Mutation_p.R114H	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	114					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GACCCGTGGCGTGTGGCGAAG	0.627									Hepatic_Adenoma_Familial_Clustering_of				0	0	0	1	0	29	42										A	121426650	G	A	121426650	3	1	18	1	0	0	0	0	1	0	0	0	7251	1145	40	2	347	2	HNF1A	12	121426650	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	851074	121426650	12425245	363	4937										
SBNO1	55206	broad.mit.edu	37	chr12	123798237	123798237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccaagtttacaatggatttCatgacaatttctaaagcatt	5	7	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:123798237C>G	uc010tap.1	-	23	3150	c.3150G>C	c.(3148-3150)ATG>ATC	p.M1050I	SBNO1_uc010tao.1_Missense_Mutation_p.M1049I|SBNO1_uc010taq.1_Missense_Mutation_p.M1I|SBNO1_uc001ues.1_Missense_Mutation_p.M1I	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1050							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CAATGGATTTCATGACAATTT	0.333													0	0	0	1	0	17	19										G	123798237	C	G	123798237	3	3	18	1	0	0	0	0	1	0	0	0	13862	826	29	1	1067	1	SBNO1	12	123798237	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2371587	123798237	10053658	364	4938										
DNAH10	196385	broad.mit.edu	37	chr12	124398990	124398990	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcacctgggagttccgtgaCgagatggtcaatcggatttg	13	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:124398990C>T	uc001uft.3	+	60	10138	c.10113C>T	c.(10111-10113)GAC>GAT	p.D3371D		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3371					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGTTCCGTGACGAGATGGTCA	0.597													0	0	0	1	0	48	55										T	124398990	C	T	124398990	2	4	18	1	0	0	0	0	0	0	0	1	4598	535	19	2		2	DNAH10	12	124398990	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	600753	124398990	9452905	365	4939										
RIMBP2	23504	broad.mit.edu	37	chr12	130926567	130926567	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cttgacgatgtcgaactcctCctcgttgaggaagatgacgt	11	10	0	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr12:130926567C>A	uc001uil.2	-	8	1443	c.1279G>T	c.(1279-1281)GAG>TAG	p.E427*	RIMBP2_uc001uim.2_Nonsense_Mutation_p.E335*|RIMBP2_uc001uin.1_Nonsense_Mutation_p.E86*	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	427	Fibronectin type-III 2.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCGAACTCCTCCTCGTTGAGG	0.572													1	0	2.66076e-39	1	2.8366e-39	57	67										A	130926567	C	A	130926567	4	1	18	1	0	0	0	0	0	1	0	0	13363	864	30	3	1927	3	RIMBP2	12	130926567	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6527577	130926567	2925328	366	4940										
MPHOSPH8	54737	broad.mit.edu	37	chr13	20222578	20222578	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcaggacaaagaaaccaaaaGaaatgaatccaaagaaaaat	6	6	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:20222578G>C	uc001umh.2	+	4	1244	c.1235G>C	c.(1234-1236)AGA>ACA	p.R412T	MPHOSPH8_uc001umg.2_Missense_Mutation_p.R412T|MPHOSPH8_uc001umi.2_Missense_Mutation_p.R109T	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	412					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GAAACCAAAAGAAATGAATCC	0.318													0	0	0	1	0	6	10										C	20222578	G	C	20222578	3	2	18	1	0	0	0	0	1	0	0	0	9727	942	33	1	1249	1	MPHOSPH8	13	20222578	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		20222578	94947300	367	4941										
SLC7A1	6541	broad.mit.edu	37	chr13	30091761	30091761	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccagagattttggaaggctCcatgtttttgggtgagagta	13	6	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:30091761C>G	uc001uso.2	-	10	1846	c.1459G>C	c.(1459-1461)GAG>CAG	p.E487Q		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	487	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TTGGAAGGCTCCATGTTTTTG	0.463													0	0	0	1	0	82	79										G	30091761	C	G	30091761	3	3	18	1	0	0	0	0	1	0	0	0	14692	864	30	1	446	1	SLC7A1	13	30091761	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	9869183	30091761	85078117	368	4942										
C13orf36	400120	broad.mit.edu	37	chr13	37269507	37269507	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagtctgcagcatttcctctCagaggtccactttttcaaac	6	12	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:37269507C>T	uc001uvt.3	+	2	738	c.292C>T	c.(292-294)CAG>TAG	p.Q98*		NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120	98						integral to membrane				skin(1)	1						CATTTCCTCTCAGAGGTCCAC	0.483													0	0	0	1	0	35	37										T	37269507	C	T	37269507	4	4	18	1	0	0	0	0	0	1	0	0	1730	827	29	1	294	1	C13orf36	13	37269507	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7177746	37269507	77900371	369	4943										
FREM2	341640	broad.mit.edu	37	chr13	39432167	39432167	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggctatcctgtcatctgtatCacagtgagtaggagattcac	10	9	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:39432167C>G	uc001uwv.2	+	13	7521	c.7212C>G	c.(7210-7212)ATC>ATG	p.I2404M	FREM2_uc001uww.2_Missense_Mutation_p.I490M	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2404	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCATCTGTATCACAGTGAGTA	0.353													0	0	0	1	0	43	88										G	39432167	C	G	39432167	3	3	18	1	0	0	0	0	1	0	0	0	6045	816	29	1	7262	1	FREM2	13	39432167	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2162660	39432167	75737711	370	4944										
RB1	5925	broad.mit.edu	37	chr13	49050910	49050910	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctcaaaagaagtgctgaagGaagcaaccctcctaaaccac	8	12	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:49050910G>T	uc001vcb.2	+	25	2760	c.2594G>T	c.(2593-2595)GGA>GTA	p.G865V		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	865	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGTGCTGAAGGAAGCAACCCT	0.383		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			1	0	6.81593e-30	1	7.21618e-30	46	78										T	49050910	G	T	49050910	3	4	18	1	0	0	0	0	1	0	0	0	13098	1174	41	3	2692	3	RB1	13	49050910	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	9618743	49050910	66118968	371	4945										
MYCBP2	23077	broad.mit.edu	37	chr13	77642919	77642919	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcatgttcccattcttcacgGactctggtagcttccatgcg	9	13	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:77642919G>C	uc001vkf.2	-	71	11929	c.11838C>G	c.(11836-11838)GTC>GTG	p.V3946V	MYCBP2_uc010aev.2_Silent_p.V3350V|MYCBP2_uc001vke.2_Silent_p.V563V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3946					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATTCTTCACGGACTCTGGTAG	0.398													0	0	0	1	0	59	56										C	77642919	G	C	77642919	2	2	18	1	0	0	0	0	0	0	0	1	10018	1161	41	1		1	MYCBP2	13	77642919	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	28592009	77642919	37526959	372	4946										
EDNRB	1910	broad.mit.edu	37	chr13	78474013	78474013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccttaaagcagtttttgaatCttttgctcaccaaatacaga	5	9	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:78474013C>G	uc001vko.2	-	6	1433	c.1175G>C	c.(1174-1176)AGA>ACA	p.R392T	EDNRB_uc001vkq.1_Missense_Mutation_p.R392T|uc001vkn.1_Intron|EDNRB_uc010aez.1_Missense_Mutation_p.R392T|EDNRB_uc001vkp.1_Missense_Mutation_p.R475T	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	392	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GTTTTTGAATCTTTTGCTCAC	0.338													0	0	0	1	0	39	36										G	78474013	C	G	78474013	3	3	18	1	0	0	0	0	1	0	0	0	4920	913	32	1	282	1	EDNRB	13	78474013	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	831094	78474013	36695865	373	4947										
SLITRK5	26050	broad.mit.edu	37	chr13	88328479	88328479	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagggacttggacgaggtatCcaagcaggaactttgcccaa	12	9	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr13:88328479C>G	uc001vln.2	+	2	1055	c.836C>G	c.(835-837)TCC>TGC	p.S279C	SLITRK5_uc010tic.1_Missense_Mutation_p.S38C	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	279	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GACGAGGTATCCAAGCAGGAA	0.542													0	0	0	1	0	32	77										G	88328479	C	G	88328479	3	3	18	1	0	0	0	0	1	0	0	0	14746	855	30	1	838	1	SLITRK5	13	88328479	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	9854466	88328479	26841399	374	4948										
TEP1	7011	broad.mit.edu	37	chr14	20876254	20876254	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acagtgctctttagactagaGagggtggccaggcaccggtt	14	9	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:20876254G>A	uc001vxe.2	-	2	385	c.345C>T	c.(343-345)CTC>CTT	p.L115L	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.L115L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	115	TEP1 N-terminal 4.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TTAGACTAGAGAGGGTGGCCA	0.512													0	0	0	1	0	67	110										A	20876254	G	A	20876254	2	1	18	1	0	0	0	0	0	0	0	1	15756	929	33	1		1	TEP1	14	20876254	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		20876254	86473286	375	4949										
SUPT16H	11198	broad.mit.edu	37	chr14	21822642	21822642	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggtcatcaacaatggtcttCatgattttagtccagttgag	10	7	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:21822642C>G	uc001wao.2	-	23	3057	c.2718G>C	c.(2716-2718)ATG>ATC	p.M906I	SUPT16H_uc001wan.2_Missense_Mutation_p.M50I	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	906					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CAATGGTCTTCATGATTTTAG	0.463													0	0	0	1	0	46	58										G	21822642	C	G	21822642	3	3	18	1	0	0	0	0	1	0	0	0	15393	826	29	1	441	1	SUPT16H	14	21822642	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	946388	21822642	85526898	376	4950										
CMTM5	116173	broad.mit.edu	37	chr14	23847933	23847933	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctagatctactctcccactCagcaaaggtccagccccagc	7	17	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:23847933C>T	uc010akm.2	+	3	779	c.335C>T	c.(334-336)TCA>TTA	p.S112L	CMTM5_uc001wjs.2_Intron|CMTM5_uc001wjt.2_Intron|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	112	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CTCTCCCACTCAGCAAAGGTC	0.632													0	0	0	1	0	33	59										T	23847933	C	T	23847933	3	4	18	1	0	0	0	0	1	0	0	0	3586	841	29	1		1	CMTM5	14	23847933	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2025291	23847933	83501607	377	4951										
CTSG	1511	broad.mit.edu	37	chr14	25044531	25044531	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcaccaggaaccctccacatCtgctctgacctgctggactc	8	17	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:25044531C>G	uc001wpq.2	-	2	180	c.143G>C	c.(142-144)AGA>ACA	p.R48T		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	48	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CCCTCCACATCTGCTCTGACC	0.592													0	0	0	1	0	114	136										G	25044531	C	G	25044531	3	3	18	1	0	0	0	0	1	0	0	0	4035	913	32	1	640	1	CTSG	14	25044531	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1196598	25044531	82305009	378	4952										
BAZ1A	11177	broad.mit.edu	37	chr14	35227966	35227966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtcatcatgtcgtaccaattCtacaacaagttgttcaaaag	6	9	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:35227966C>G	uc001wsk.2	-	25	4898	c.4330G>C	c.(4330-4332)GAA>CAA	p.E1444Q	BAZ1A_uc001wsl.2_Missense_Mutation_p.E1412Q	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1444					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CGTACCAATTCTACAACAAGT	0.393													0	0	0	1	0	41	74										G	35227966	C	G	35227966	3	3	18	1	0	0	0	0	1	0	0	0	1329	922	32	1	352	1	BAZ1A	14	35227966	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10183435	35227966	72121574	379	4953										
DLGAP5	9787	broad.mit.edu	37	chr14	55642131	55642131	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctttcaagtgatgggacttCttttattggaaggccattta	9	6	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:55642131C>T	uc001xbs.2	-	10	1451	c.1234G>A	c.(1234-1236)GAA>AAA	p.E412K	DLGAP5_uc001xbt.2_Missense_Mutation_p.E412K	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	412					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						GATGGGACTTCTTTTATTGGA	0.313													0	0	0	1	0	21	16										T	55642131	C	T	55642131	3	4	18	1	0	0	0	0	1	0	0	0	4563	922	32	1	1441	1	DLGAP5	14	55642131	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	20414165	55642131	51707409	380	4954										
C14orf105	55195	broad.mit.edu	37	chr14	57947337	57947337	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acctctgttcaagatttcatCaggcaacatggttagaaggt	9	8	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:57947337C>T	uc001xcy.2	-	5	774	c.631G>A	c.(631-633)GAT>AAT	p.D211N	C14orf105_uc010trl.1_Missense_Mutation_p.D210N|C14orf105_uc010trm.1_Missense_Mutation_p.D122N|C14orf105_uc010trn.1_Missense_Mutation_p.D122N|C14orf105_uc001xcz.2_Missense_Mutation_p.D210N|C14orf105_uc010aox.1_RNA|C14orf105_uc010aoy.1_Missense_Mutation_p.D132N	NM_018168	NP_060638	Q9NVL8	CN105_HUMAN	hypothetical protein LOC55195	211											0						AAGATTTCATCAGGCAACATG	0.393													0	0	0	1	0	59	89										T	57947337	C	T	57947337	3	4	18	1	0	0	0	0	1	0	0	0	1737	826	29	1	267	1	C14orf105	14	57947337	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2305206	57947337	49402203	381	4955										
SYNE2	23224	broad.mit.edu	37	chr14	64522742	64522742	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtggagagcatcacttccctCgaagccatcattatacccta	7	13	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:64522742C>T	uc001xgm.2	+	49	10055	c.9825C>T	c.(9823-9825)CTC>CTT	p.L3275L	SYNE2_uc001xgl.2_Silent_p.L3275L|SYNE2_uc010apw.1_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3275	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCACTTCCCTCGAAGCCATCA	0.408													0	0	0	1	0	44	53										T	64522742	C	T	64522742	2	4	18	1	0	0	0	0	0	0	0	1	15443	871	31	1		1	SYNE2	14	64522742	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6575405	64522742	42826798	382	4956										
SYNE2	23224	broad.mit.edu	37	chr14	64593421	64593421	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agaacaccaacttgctccttGaatgttttgacaaccttcaa	5	11	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:64593421G>C	uc001xgm.2	+	73	14043	c.13813G>C	c.(13813-13815)GAA>CAA	p.E4605Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E4605Q|SYNE2_uc010apy.2_Missense_Mutation_p.E990Q|SYNE2_uc010apz.1_Missense_Mutation_p.E497Q	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4605	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTTGCTCCTTGAATGTTTTGA	0.478													0	0	0	1	0	55	59										C	64593421	G	C	64593421	3	2	18	1	0	0	0	0	1	0	0	0	15443	1291	45	1	14099	1	SYNE2	14	64593421	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	70679	64593421	42756119	383	4957										
SIPA1L1	26037	broad.mit.edu	37	chr14	72176165	72176165	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgccacatcgtcacctcgctCagggccaggcaaggagaaag	12	13	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:72176165C>G	uc001xms.2	+	15	4403	c.4055C>G	c.(4054-4056)TCA>TGA	p.S1352*	SIPA1L1_uc001xmt.2_Nonsense_Mutation_p.S1331*|SIPA1L1_uc001xmu.2_Nonsense_Mutation_p.S1331*|SIPA1L1_uc001xmv.2_Nonsense_Mutation_p.S1352*|SIPA1L1_uc010ttm.1_Nonsense_Mutation_p.S806*|SIPA1L1_uc001xmw.2_Nonsense_Mutation_p.S117*	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1352	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TCACCTCGCTCAGGGCCAGGC	0.612													0	0	0	1	0	32	50										G	72176165	C	G	72176165	4	3	18	1	0	0	0	0	0	1	0	0	14329	838	29	1	4109	1	SIPA1L1	14	72176165	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7582744	72176165	35173375	384	4958										
PAPLN	89932	broad.mit.edu	37	chr14	73727502	73727502	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgtatggtggtgacagcaccGggggcatgcccaggtcaagg	17	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:73727502G>A	uc010ttx.1	+	16	2234	c.2071G>A	c.(2071-2073)GGG>AGG	p.G691R	PAPLN_uc001xnw.3_Missense_Mutation_p.G664R|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.G691R|PAPLN_uc010arm.2_5'UTR|PAPLN_uc010arn.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	691						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		TGACAGCACCGGGGGCATGCC	0.637													0	0	0	1	0	26	19										A	73727502	G	A	73727502	3	1	18	1	0	0	0	0	1	0	0	0	11428	1116	39	2	2048	2	PAPLN	14	73727502	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1551337	73727502	33622038	385	4959										
TGFB3	7043	broad.mit.edu	37	chr14	76427367	76427367	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gacccacttccagcccagatCctgtcggaagtcaatgtaga	9	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:76427367C>G	uc001xsc.2	-	6	1835	c.979G>C	c.(979-981)GAT>CAT	p.D327H		NM_003239	NP_003230	P10600	TGFB3_HUMAN	transforming growth factor, beta 3 precursor	327					cell growth|cell-cell junction organization|detection of hypoxia|face morphogenesis|in utero embryonic development|induction of apoptosis|lung alveolus development|mammary gland development|menstrual cycle phase|negative regulation of cell proliferation|negative regulation of DNA replication|negative regulation of macrophage cytokine production|negative regulation of neuron apoptosis|odontogenesis|ossification involved in bone remodeling|palate development|platelet activation|platelet degranulation|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of collagen biosynthetic process|positive regulation of DNA replication|positive regulation of epithelial to mesenchymal transition|positive regulation of filopodium assembly|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|response to progesterone stimulus|salivary gland morphogenesis|transforming growth factor beta receptor signaling pathway	extracellular matrix|platelet alpha granule lumen	growth factor activity|identical protein binding|transforming growth factor beta binding|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0169)		CAGCCCAGATCCTGTCGGAAG	0.488													0	0	0	1	0	54	85										G	76427367	C	G	76427367	3	3	18	1	0	0	0	0	1	0	0	0	15816	855	30	1	267	1	TGFB3	14	76427367	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2699865	76427367	30922173	386	4960										
TTC7B	145567	broad.mit.edu	37	chr14	91123528	91123528	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccctactcacccagtgcaggGagcccatgcagagcttggca	11	15	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr14:91123528G>C	uc001xyp.2	-	11	1453	c.1331C>G	c.(1330-1332)TCC>TGC	p.S444C	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	444							binding			ovary(2)	2		Melanoma(154;0.222)				CCAGTGCAGGGAGCCCATGCA	0.622													0	0	0	1	0	44	76										C	91123528	G	C	91123528	3	2	18	1	0	0	0	0	1	0	0	0	16710	1174	41	1	1240	1	TTC7B	14	91123528	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	14696161	91123528	16226012	387	4961										
ATP10A	57194	broad.mit.edu	37	chr15	25981266	25981266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	attcgatcacgctggtgaacGtcaaaggattgaattcggag	12	7	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:25981266G>A	uc010ayu.2	-	3	783	c.677C>T	c.(676-678)ACG>ATG	p.T226M		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	226	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCTGGTGAACGTCAAAGGATT	0.507													0	0	0	1	0	24	43										A	25981266	G	A	25981266	3	1	18	1	0	0	0	0	1	0	0	0	1116	1145	40	2	3898	2	ATP10A	15	25981266	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		25981266	76550126	388	4962										
GABRG3	2567	broad.mit.edu	37	chr15	27772741	27772741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cctcaactactattccagctGtagaaaaccaaccaccacga	4	15	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:27772741G>A	uc001zbg.1	+	8	1194	c.1028G>A	c.(1027-1029)TGT>TAT	p.C343Y		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	343	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TATTCCAGCTGTAGAAAACCA	0.522													0	0	0	1	0	11	15										A	27772741	G	A	27772741	3	1	18	1	0	0	0	0	1	0	0	0	6173	1377	48	2	1058	2	GABRG3	15	27772741	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1791475	27772741	74758651	389	4963										
RAD51	5888	broad.mit.edu	37	chr15	41023291	41023291	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagaggggaaaccagaatctGcaaaatctacgactctccct	8	11	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:41023291G>A	uc001zmi.3	+	10	1234	c.935G>A	c.(934-936)TGC>TAC	p.C312Y	RAD51_uc010bbw.2_Silent_p.L271L|RAD51_uc010bbx.2_Missense_Mutation_p.C313Y|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.C313Y	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	312					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		ACCAGAATCTGCAAAATCTAC	0.423								Homologous_recombination					0	0	0	1	0	50	66										A	41023291	G	A	41023291	3	1	18	1	0	0	0	0	1	0	0	0	12985	1319	46	2	1094	2	RAD51	15	41023291	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	13250550	41023291	61508101	390	4964										
VPS18	57617	broad.mit.edu	37	chr15	41192994	41192994	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgaacgtgctgggggagactGagcaggccatccacaactac	13	11	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:41192994G>A	uc001zne.2	+	4	2317	c.1978G>A	c.(1978-1980)GAG>AAG	p.E660K		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	660	Clathrin.				endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGGGGAGACTGAGCAGGCCAT	0.637													0	0	0	1	0	94	105										A	41192994	G	A	41192994	3	1	18	1	0	0	0	0	1	0	0	0	17191	1291	45	1	1992	1	VPS18	15	41192994	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	169703	41192994	61338398	391	4965										
FBN1	2200	broad.mit.edu	37	chr15	48741027	48741027	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcaaaggcaataaaagcttCcaactgtgtcaatgcactgc	9	10	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:48741027C>T	uc001zwx.1	-	46	5937	c.5609G>A	c.(5608-5610)GGA>GAA	p.G1870E	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1870	EGF-like 31; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATAAAAGCTTCCAACTGTGTC	0.353													0	0	0	1	0	31	36										T	48741027	C	T	48741027	3	4	18	1	0	0	0	0	1	0	0	0	5702	855	30	1	3090	1	FBN1	15	48741027	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7548033	48741027	53790365	392	4966										
LEO1	123169	broad.mit.edu	37	chr15	52258162	52258162	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcagatagctgttgtctctCatcatcggaaagctgaggcc	10	11	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:52258162C>T	uc002abo.2	-	2	614	c.598G>A	c.(598-600)GAG>AAG	p.E200K	LEO1_uc010bfd.2_Missense_Mutation_p.E200K	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	200	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TGTTGTCTCTCATCATCGGAA	0.438													0	0	0	1	0	150	193										T	52258162	C	T	52258162	3	4	18	1	0	0	0	0	1	0	0	0	8726	835	29	1	1446	1	LEO1	15	52258162	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3517135	52258162	50273230	393	4967										
TLN2	83660	broad.mit.edu	37	chr15	63008574	63008574	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaggaccagcagcaaaggctGagagaagctgcagaaggcct	15	9	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:63008574G>C	uc002alb.3	+	20	2679	c.2679G>C	c.(2677-2679)CTG>CTC	p.L893L		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	893	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AGCAAAGGCTGAGAGAAGCTG	0.502													0	0	0	1	0	35	48										C	63008574	G	C	63008574	2	2	18	1	0	0	0	0	0	0	0	1	15945	1277	45	1		1	TLN2	15	63008574	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10750412	63008574	39522818	394	4968										
HCN4	10021	broad.mit.edu	37	chr15	73615897	73615897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acggtgtgtccacctgggacGggctgctggcgggcgaggcg	20	11	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:73615897G>A	uc002avp.2	-	8	3531	c.2537C>T	c.(2536-2538)CCG>CTG	p.P846L		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	846	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		CACCTGGGACGGGCTGCTGGC	0.672													0	0	0	1	0	54	84										A	73615897	G	A	73615897	3	1	18	1	0	0	0	0	1	0	0	0	6999	1116	39	2	1078	2	HCN4	15	73615897	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10607323	73615897	28915495	395	4969										
C15orf39	56905	broad.mit.edu	37	chr15	75498861	75498861	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgaagaggccactggatgttGactggactctggcgactggg	16	8	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:75498861G>C	uc002azp.3	+	2	792	c.472G>C	c.(472-474)GAC>CAC	p.D158H	C15orf39_uc002azq.3_Missense_Mutation_p.D158H|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	158											0						ACTGGATGTTGACTGGACTCT	0.612													0	0	0	1	0	42	71										C	75498861	G	C	75498861	3	2	18	1	0	0	0	0	1	0	0	0	1793	1290	45	1	474	1	C15orf39	15	75498861	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1882964	75498861	27032531	396	4970										
NEIL1	79661	broad.mit.edu	37	chr15	75641328	75641328	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggtgttcggcggctgcgtgGagaagtcctctgtcagccgc	16	11	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:75641328G>T	uc002bad.2	+	2	588	c.82G>T	c.(82-84)GAG>TAG	p.E28*	NEIL1_uc002bae.2_Nonsense_Mutation_p.E114*	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	nei endonuclease VIII-like 1	28					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|protein C-terminus binding|zinc ion binding			ovary(1)	1						CGGCTGCGTGGAGAAGTCCTC	0.647								BER_DNA_glycosylases					1	0	1.74807e-11	1	1.78893e-11	29	60										T	75641328	G	T	75641328	4	4	18	1	0	0	0	0	0	1	0	0	10318	1175	41	3	84	3	NEIL1	15	75641328	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	142467	75641328	26890064	397	4971										
SEC11A	23478	broad.mit.edu	37	chr15	85259297	85259297	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cacatcgtccaaaaagtctaGagacagcatggcggggacgg	13	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:85259297G>C	uc002blb.1	-	1	378	c.10C>G	c.(10-12)CTA>GTA	p.L4V	SEC11A_uc002blc.1_5'UTR	NM_014300	NP_055115	P67812	SC11A_HUMAN	SEC11-like 1	4	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	protein binding|serine-type peptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(143;0.199)			AAAAAGTCTAGAGACAGCATG	0.622													0	0	0	1	0	21	23										C	85259297	G	C	85259297	3	2	18	1	0	0	0	0	1	0	0	0	13978	933	33	1	553	1	SEC11A	15	85259297	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	9617969	85259297	17272095	398	4972										
AGBL1	123624	broad.mit.edu	37	chr15	86807733	86807733	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cctgtaccaaaatgtgcaatCcaatagtctcaggagagatt	8	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:86807733C>G	uc002blz.1	+	10	1273	c.1193C>G	c.(1192-1194)TCC>TGC	p.S398C	AGBL1_uc002bma.1_Missense_Mutation_p.S129C|AGBL1_uc002bmb.1_Missense_Mutation_p.S92C	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	398					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						AATGTGCAATCCAATAGTCTC	0.488													0	0	0	1	0	17	42										G	86807733	C	G	86807733	3	3	18	1	0	0	0	0	1	0	0	0	375	855	30	1	1227	1	AGBL1	15	86807733	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1548436	86807733	15723659	399	4973										
BLM	641	broad.mit.edu	37	chr15	91341444	91341444	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ataaaacaagagatgtgactGacgatgtgaaaagtattgta	10	3	0	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:91341444G>A	uc002bpr.2	+	17	3332	c.3235G>A	c.(3235-3237)GAC>AAC	p.D1079N	BLM_uc010uqh.1_Missense_Mutation_p.D1079N|BLM_uc010uqi.1_Missense_Mutation_p.D704N|BLM_uc010bnx.2_Missense_Mutation_p.D1079N|BLM_uc002bpt.2_Missense_Mutation_p.D54N	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1079					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AGATGTGACTGACGATGTGAA	0.294			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				0	0	0	1	0	32	32										A	91341444	G	A	91341444	3	1	18	1	0	0	0	0	1	0	0	0	1445	1290	45	1	3297	1	BLM	15	91341444	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4533711	91341444	11189948	400	4974										
IGF1R	3480	broad.mit.edu	37	chr15	99467847	99467847	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggaactacacagcccggattCaggccacatctctctctggg	10	14	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr15:99467847C>T	uc002bul.2	+	13	2766	c.2716C>T	c.(2716-2718)CAG>TAG	p.Q906*	IGF1R_uc010bon.2_Nonsense_Mutation_p.Q906*|IGF1R_uc010boo.1_RNA	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	906	Extracellular (Potential).|Fibronectin type-III 3.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	AGCCCGGATTCAGGCCACATC	0.527													0	0	0	1	0	36	81										T	99467847	C	T	99467847	4	4	18	1	0	0	0	0	0	1	0	0	7571	827	29	1	2766	1	IGF1R	15	99467847	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	8126403	99467847	3063545	401	4975										
GNPTG	84572	broad.mit.edu	37	chr16	1412126	1412126	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgccgttcccggagccggcaGagcaaggtggggcctcagac	16	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:1412126G>A	uc002clm.2	+	6	440	c.405G>A	c.(403-405)CAG>CAA	p.Q135Q		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	135						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				GGAGCCGGCAGAGCAAGGTGG	0.667													0	0	0	1	0	8	0										A	1412126	G	A	1412126	2	1	18	1	0	0	0	0	0	0	0	1	6546	933	33	1		1	GNPTG	16	1412126	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		1412126	88942627	402	4976										
TSC2	7249	broad.mit.edu	37	chr16	2110794	2110794	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttctgctgaacatcatcgaaCggctccttcagcagctccag	8	14	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2110794C>T	uc002con.2	+	11	1205	c.1099C>T	c.(1099-1101)CGG>TGG	p.R367W	TSC2_uc010bsd.2_Missense_Mutation_p.R367W|TSC2_uc002coo.2_Missense_Mutation_p.R367W|TSC2_uc010uvv.1_Missense_Mutation_p.R330W|TSC2_uc010uvw.1_Missense_Mutation_p.R318W|TSC2_uc002cop.2_Missense_Mutation_p.R167W	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	367	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CATCATCGAACGGCTCCTTCA	0.602			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	1	0	47	8										T	2110794	C	T	2110794	3	4	18	1	0	0	0	0	1	0	0	0	16603	527	19	2	1137	2	TSC2	16	2110794	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	698668	2110794	88243959	403	4977										
CEMP1	752014	broad.mit.edu	37	chr16	2580759	2580759	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcctgggcagggcctcgcctGagggagggcctggggcaggg	22	11	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2580759G>A	uc002cqr.2	-	1	672	c.316C>T	c.(316-318)CAG>TAG	p.Q106*	AMDHD2_uc010uwc.1_Silent_p.*595*|AMDHD2_uc010uwd.1_Silent_p.*359*	NM_001048212	NP_001041677	Q6PRD7	CEMP1_HUMAN	cementum protein 1	106						cytoplasm				skin(1)	1						GGCCTCGCCTGAGGGAGGGCC	0.632													0	0	0	1	0	17	4										A	2580759	G	A	2580759	4	1	18	1	0	0	0	0	0	1	0	0	3224	1303	45	1	431	1	CEMP1	16	2580759	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	469965	2580759	87773994	404	4978										
SRRM2	23524	broad.mit.edu	37	chr16	2814872	2814872	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgggtcttctccaggacttaGagatgggtctgggactccct	13	10	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2814872G>C	uc002crk.2	+	11	4892	c.4343G>C	c.(4342-4344)AGA>ACA	p.R1448T	SRRM2_uc002crj.1_Missense_Mutation_p.R1352T|SRRM2_uc002crl.1_Missense_Mutation_p.R1448T|SRRM2_uc010bsu.1_Missense_Mutation_p.R1352T	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1448	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCAGGACTTAGAGATGGGTCT	0.493													0	0	0	1	0	86	22										C	2814872	G	C	2814872	3	2	18	1	0	0	0	0	1	0	0	0	15168	942	33	1	4381	1	SRRM2	16	2814872	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	234113	2814872	87539881	405	4979										
SRRM2	23524	broad.mit.edu	37	chr16	2815072	2815072	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agtgtcttaccccccagagaGaaagaagcgggtcagaatca	11	10	3	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:2815072G>C	uc002crk.2	+	11	5092	c.4543G>C	c.(4543-4545)GAA>CAA	p.E1515Q	SRRM2_uc002crj.1_Missense_Mutation_p.E1419Q|SRRM2_uc002crl.1_Missense_Mutation_p.E1515Q|SRRM2_uc010bsu.1_Missense_Mutation_p.E1419Q	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1515	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCCCCAGAGAGAAAGAAGCGG	0.522													0	0	0	1	0	135	37										C	2815072	G	C	2815072	3	2	18	1	0	0	0	0	1	0	0	0	15168	943	33	1	4581	1	SRRM2	16	2815072	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	200	2815072	87539681	406	4980										
ADCY9	115	broad.mit.edu	37	chr16	4016668	4016668	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgctggcgaagatcacccctCcgctgtcatggttcttggag	12	12	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:4016668C>G	uc002cvx.2	-	11	3709	c.3170G>C	c.(3169-3171)GGA>GCA	p.G1057A		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1057	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						GATCACCCCTCCGCTGTCATG	0.592													0	0	0	1	0	156	35										G	4016668	C	G	4016668	3	3	18	1	0	0	0	0	1	0	0	0	301	855	30	1	895	1	ADCY9	16	4016668	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1201596	4016668	86338085	407	4981										
HMOX2	3163	broad.mit.edu	37	chr16	4556895	4556895	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acacctcccatctctccacaGaatggctgacctctcggagc	7	17	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:4556895G>A	uc010bts.2	+	3	258	c.87_splice	c.e3-1	p.R29_splice	HMOX2_uc002cwr.3_Splice_Site_p.R29_splice|HMOX2_uc002cwq.3_Splice_Site_p.R29_splice|HMOX2_uc002cws.3_Splice_Site_p.R83_splice|HMOX2_uc010btt.2_Splice_Site_p.R29_splice|HMOX2_uc002cwt.2_Splice_Site_p.R29_splice	NM_001127206	NP_001120678	P30519	HMOX2_HUMAN	heme oxygenase (decyclizing) 2						cellular iron ion homeostasis|heme catabolic process|heme oxidation|response to hypoxia|transmembrane transport	endoplasmic reticulum membrane|microsome|plasma membrane	electron carrier activity|heme oxygenase (decyclizing) activity|metal ion binding|protein binding				0					NADH(DB00157)	TCTCTCCACAGAATGGCTGAC	0.517											OREG0023582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	112	30										A	4556895	G	A	4556895	5	1	18	1	0	0	0	0	0	0	1	0	7244	956	33	1	92	1	HMOX2	16	4556895	Splice_Site	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	540227	4556895	85797858	408	4982										
DNAH3	55567	broad.mit.edu	37	chr16	21136611	21136611	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	attcctcaatgtttcgacttGagtcatagttgctcttggga	9	8	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:21136611G>C	uc010vbe.1	-	9	1289	c.1289C>G	c.(1288-1290)TCA>TGA	p.S430*	DNAH3_uc002die.2_Nonsense_Mutation_p.S401*	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	430	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTTTCGACTTGAGTCATAGTT	0.483													0	0	0	1	0	63	21										C	21136611	G	C	21136611	4	2	18	1	0	0	0	0	0	1	0	0	4603	1294	45	1	11276	1	DNAH3	16	21136611	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	16579716	21136611	69218142	409	4983										
TMEM159	57146	broad.mit.edu	37	chr16	21172532	21172532	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agaggagccccagagtatctCaagggacttgcaggaactgc	13	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:21172532C>G	uc002dif.3	+	2	390	c.29C>G	c.(28-30)TCA>TGA	p.S10*	DNAH3_uc010vbe.1_5'Flank|TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Nonsense_Mutation_p.S10*|TMEM159_uc002dih.3_Nonsense_Mutation_p.S10*	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	10						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		CAGAGTATCTCAAGGGACTTG	0.438													0	0	0	1	0	29	9										G	21172532	C	G	21172532	4	3	18	1	0	0	0	0	0	1	0	0	16071	838	29	1	31	1	TMEM159	16	21172532	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	35921	21172532	69182221	410	4984										
CLN3	1201	broad.mit.edu	37	chr16	28493700	28493700	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gttccagaaaaagaggagttCaaactgcaacaaataccaga	8	8	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:28493700C>G	uc002dpo.2	-	12	1233	c.910G>C	c.(910-912)GAA>CAA	p.E304Q	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.E226Q|CLN3_uc010vcu.1_Missense_Mutation_p.E204Q|CLN3_uc002dpn.2_Missense_Mutation_p.E205Q|CLN3_uc002dpm.2_Missense_Mutation_p.E250Q|CLN3_uc010vcv.1_Missense_Mutation_p.E280Q|CLN3_uc010byd.2_Intron|CLN3_uc002dpp.2_Missense_Mutation_p.E304Q|CLN3_uc002dpt.1_Missense_Mutation_p.E204Q|CLN3_uc002dpq.1_Missense_Mutation_p.E256Q|CLN3_uc010bye.1_Missense_Mutation_p.E287Q|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.E177Q|CLN3_uc002dpu.1_Missense_Mutation_p.E202Q|CLN3_uc002dpw.1_Missense_Mutation_p.E151Q|CLN3_uc010vcw.1_Missense_Mutation_p.E250Q|CLN3_uc002dqa.2_3'UTR|CLN3_uc010vcx.1_3'UTR	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	304					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						AAGAGGAGTTCAAACTGCAAC	0.592													0	0	0	1	0	27	39										G	28493700	C	G	28493700	3	3	18	1	0	0	0	0	1	0	0	0	3543	835	29	1	422	1	CLN3	16	28493700	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	7321168	28493700	61861053	411	4985										
CD19	930	broad.mit.edu	37	chr16	28948444	28948444	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggagccttggggtcccggagCccgccgggagtgggtgaatg	20	10	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:28948444C>T	uc002drs.2	+	8	1247	c.1185C>T	c.(1183-1185)AGC>AGT	p.S395S	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.S395S	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	395	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						GGTCCCGGAGCCCGCCGGGAG	0.692													0	0	0	1	0	4	6										T	28948444	C	T	28948444	2	4	18	1	0	0	0	0	0	0	0	1	2973	738	26	2		2	CD19	16	28948444	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	454744	28948444	61406309	412	4986										
RNF40	9810	broad.mit.edu	37	chr16	30777495	30777495	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	actccttagtttgagatgctGaatgcagagttagaggaaaa	11	5	0	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:30777495G>A	uc002dzq.2	+	9	1128	c.1005G>A	c.(1003-1005)CTG>CTA	p.L335L	RNF40_uc010caa.2_Silent_p.L335L|RNF40_uc010cab.2_Intron|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Silent_p.L335L|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	335	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			TTGAGATGCTGAATGCAGAGT	0.592													0	0	0	1	0	53	88										A	30777495	G	A	30777495	2	1	18	1	0	0	0	0	0	0	0	1	13493	1277	45	1		1	RNF40	16	30777495	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1829051	30777495	59577258	413	4987										
MYLK3	91807	broad.mit.edu	37	chr16	46764544	46764544	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcacacctcgtaacccgcaGagatggaggtctccttgacg	12	13	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:46764544G>C	uc002eei.3	-	5	1645	c.1529C>G	c.(1528-1530)TCT>TGT	p.S510C	MYLK3_uc010vge.1_Missense_Mutation_p.S169C|MYLK3_uc002eej.1_Missense_Mutation_p.S169C	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	510					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GTAACCCGCAGAGATGGAGGT	0.612													0	0	0	1	0	72	126										C	46764544	G	C	46764544	3	2	18	1	0	0	0	0	1	0	0	0	10058	942	33	1	966	1	MYLK3	16	46764544	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	15987049	46764544	43590209	414	4988										
NUP93	9688	broad.mit.edu	37	chr16	56857669	56857669	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caaatgacagacgtgttgttGacaccggcaacggatgccct	11	11	0	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:56857669G>A	uc002eka.2	+	8	826	c.705G>A	c.(703-705)TTG>TTA	p.L235L	NUP93_uc002ekb.2_Silent_p.L112L|NUP93_uc010vhi.1_Silent_p.L112L	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	235					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						ACGTGTTGTTGACACCGGCAA	0.517													0	0	0	1	0	77	85										A	56857669	G	A	56857669	2	1	18	1	0	0	0	0	0	0	0	1	10772	1281	45	1		1	NUP93	16	56857669	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10093125	56857669	33497084	415	4989										
SLC12A3	6559	broad.mit.edu	37	chr16	56899426	56899426	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gctgacctgcactccttcctCaaggtaagtgctgtctcaga	9	13	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:56899426C>G	uc010ccm.2	+	1	308	c.279C>G	c.(277-279)CTC>CTG	p.L93L	SLC12A3_uc002ekd.3_Silent_p.L93L|SLC12A3_uc010ccn.2_Silent_p.L93L	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	93	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ACTCCTTCCTCAAGGTAAGTG	0.373													0	0	0	1	0	32	38										G	56899426	C	G	56899426	2	3	18	1	0	0	0	0	0	0	0	1	14384	813	29	1		1	SLC12A3	16	56899426	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	41757	56899426	33455327	416	4990										
FBXL8	55336	broad.mit.edu	37	chr16	67195736	67195736	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gaggaggtgctggcactcatCttccgccacctgtccctgag	12	14	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67195736C>T	uc002erj.1	+	2	168	c.48C>T	c.(46-48)ATC>ATT	p.I16I	TRADD_uc002eri.1_5'Flank|TRADD_uc010vjb.1_5'Flank|FBXL8_uc002erk.1_Silent_p.I16I|HSF4_uc002erl.1_5'Flank|HSF4_uc002erm.1_5'Flank|HSF4_uc002ern.1_5'Flank|HSF4_uc010cec.1_5'Flank	NM_018378	NP_060848	Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	16	F-box.						protein binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		TGGCACTCATCTTCCGCCACC	0.682													0	0	0	1	0	13	17										T	67195736	C	T	67195736	2	4	18	1	0	0	0	0	0	0	0	1	5725	903	32	1		1	FBXL8	16	67195736	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10296310	67195736	23159017	417	4991										
FBXL8	55336	broad.mit.edu	37	chr16	67196840	67196840	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acggctggaatttgagccatCgaggaagccgagccgccggg	16	11	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67196840C>T	uc002erj.1	+	3	362	c.242C>T	c.(241-243)TCG>TTG	p.S81L	FBXL8_uc002erk.1_Missense_Mutation_p.S81L|HSF4_uc002erl.1_5'Flank|HSF4_uc002erm.1_5'Flank|HSF4_uc002ern.1_5'Flank|HSF4_uc010cec.1_5'Flank	NM_018378	NP_060848	Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	81							protein binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		TTTGAGCCATCGAGGAAGCCG	0.632													0	0	0	1	0	3	2										T	67196840	C	T	67196840	3	4	18	1	0	0	0	0	1	0	0	0	5725	893	31	1	248	1	FBXL8	16	67196840	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1104	67196840	23157913	418	4992										
E2F4	1874	broad.mit.edu	37	chr16	67228652	67228652	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgagtggtcccattgaggttCtgctggtgaacaaggaggca	15	7	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67228652C>G	uc002erz.2	+	6	640	c.577C>G	c.(577-579)CTG>GTG	p.L193V		NM_001950	NP_001941	Q16254	E2F4_HUMAN	E2F transcription factor 4	193					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		CATTGAGGTTCTGCTGGTGAA	0.542													0	0	0	1	0	63	58										G	67228652	C	G	67228652	3	3	18	1	0	0	0	0	1	0	0	0	4869	912	32	1	599	1	E2F4	16	67228652	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	31812	67228652	23126101	419	4993										
FAM65A	79567	broad.mit.edu	37	chr16	67575861	67575861	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcatccagcccacagctctCaggcactgcccgccactcac	6	21	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67575861C>G	uc010vjp.1	+	13	1328	c.1232C>G	c.(1231-1233)TCA>TGA	p.S411*	FAM65A_uc010cei.1_Nonsense_Mutation_p.S233*|FAM65A_uc002eth.2_Nonsense_Mutation_p.S391*|FAM65A_uc010cej.2_Nonsense_Mutation_p.S394*|FAM65A_uc002eti.1_Nonsense_Mutation_p.S354*|FAM65A_uc010vjq.1_Nonsense_Mutation_p.S405*|FAM65A_uc002etj.1_Nonsense_Mutation_p.S390*|FAM65A_uc002etk.2_Nonsense_Mutation_p.S390*	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	395						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCACAGCTCTCAGGCACTGCC	0.622													0	0	0	1	0	44	71										G	67575861	C	G	67575861	4	3	18	1	0	0	0	0	0	1	0	0	5599	838	29	1	1218	1	FAM65A	16	67575861	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	347209	67575861	22778892	420	4994										
SLC12A4	6560	broad.mit.edu	37	chr16	67985897	67985897	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agctgtcttggcacagatgtCaaactggtcccgggacaggg	14	10	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:67985897C>T	uc002euz.2	-	8	1102	c.961G>A	c.(961-963)GAC>AAC	p.D321N	SLC12A4_uc010ceu.2_Missense_Mutation_p.D315N|SLC12A4_uc010vkh.1_Missense_Mutation_p.D290N|SLC12A4_uc010vki.1_Missense_Mutation_p.D321N|SLC12A4_uc010vkj.1_Missense_Mutation_p.D323N|SLC12A4_uc002eva.2_Missense_Mutation_p.D321N|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	321					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCACAGATGTCAAACTGGTCC	0.587													0	0	0	1	0	27	44										T	67985897	C	T	67985897	3	4	18	1	0	0	0	0	1	0	0	0	14385	826	29	1	2364	1	SLC12A4	16	67985897	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	410036	67985897	22368856	421	4995										
SLC7A6OS	84138	broad.mit.edu	37	chr16	68344264	68344264	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggagcctgcagaggcggcttCaggttctccctcctcgtgga	14	13	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:68344264C>G	uc002evw.1	-	2	464	c.445G>C	c.(445-447)GAA>CAA	p.E149Q	PRMT7_uc002evx.1_5'Flank|PRMT7_uc002evy.1_5'Flank|PRMT7_uc010vlg.1_5'Flank	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	149					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		GAGGCGGCTTCAGGTTCTCCC	0.612													0	0	0	1	0	23	19										G	68344264	C	G	68344264	3	3	18	1	0	0	0	0	1	0	0	0	14702	835	29	1	500	1	SLC7A6OS	16	68344264	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	358367	68344264	22010489	422	4996										
PRMT7	54496	broad.mit.edu	37	chr16	68380131	68380131	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctggaaccggcctcggtttgGagagatcaatgaccaggaca	13	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:68380131G>C	uc002evy.1	+	11	1415	c.1139G>C	c.(1138-1140)GGA>GCA	p.G380A	PRMT7_uc002evx.1_Missense_Mutation_p.G380A|PRMT7_uc010vlg.1_Missense_Mutation_p.G330A|PRMT7_uc002evz.1_Missense_Mutation_p.G226A	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	380					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CCTCGGTTTGGAGAGATCAAT	0.562													0	0	0	1	0	49	63										C	68380131	G	C	68380131	3	2	18	1	0	0	0	0	1	0	0	0	12541	1174	41	1	1173	1	PRMT7	16	68380131	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	35867	68380131	21974622	423	4997										
CDH3	1001	broad.mit.edu	37	chr16	68721629	68721629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atctactggacggcagaggtCaacgaggaaggtacctgagt	14	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:68721629C>T	uc002ewf.2	+	12	2917	c.1785C>T	c.(1783-1785)GTC>GTT	p.V595V	CDH3_uc010vli.1_Silent_p.V540V	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	595	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CGGCAGAGGTCAACGAGGAAG	0.602													0	0	0	1	0	29	42										T	68721629	C	T	68721629	2	4	18	1	0	0	0	0	0	0	0	1	3111	813	29	1		1	CDH3	16	68721629	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	341498	68721629	21633124	424	4998										
FA2H	79152	broad.mit.edu	37	chr16	74761154	74761154	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagctcaccagacagtcttaGagaggccctcaatgaggtct	11	11	4	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:74761154G>C	uc002fde.1	-	3	562	c.494C>G	c.(493-495)TCT>TGT	p.S165C	FA2H_uc010vmy.1_Intron	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	165					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						GACAGTCTTAGAGAGGCCCTC	0.587													0	0	0	1	0	25	38										C	74761154	G	C	74761154	3	2	18	1	0	0	0	0	1	0	0	0	5352	942	33	1	644	1	FA2H	16	74761154	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6039525	74761154	15593599	425	4999										
LDHD	197257	broad.mit.edu	37	chr16	75150574	75150574	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttctgggagcagtagcccctCcaggggaacagctcccaggt	13	13	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:75150574C>G	uc002fdm.2	-	1	92	c.45G>C	c.(43-45)TGG>TGC	p.W15C	LDHD_uc002fdn.2_Missense_Mutation_p.W15C	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	15							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						AGTAGCCCCTCCAGGGGAACA	0.627													0	0	0	1	0	70	112										G	75150574	C	G	75150574	3	3	18	1	0	0	0	0	1	0	0	0	8703	856	30	1	1522	1	LDHD	16	75150574	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	389420	75150574	15204179	426	5000										
TERF2IP	54386	broad.mit.edu	37	chr16	75690294	75690294	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggagaagtttaacttggatCtatcaacagttacacaggcc	9	8	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:75690294C>A	uc002fet.1	+	3	1082	c.985C>A	c.(985-987)CTA>ATA	p.L329I		NM_018975	NP_061848	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting	329					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1						TAACTTGGATCTATCAACAGT	0.388													1	0	1.4958e-60	1	1.60582e-60	93	168										A	75690294	C	A	75690294	3	1	18	1	0	0	0	0	1	0	0	0	15760	912	32	3	995	3	TERF2IP	16	75690294	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	539720	75690294	14664459	427	5001										
CENPN	55839	broad.mit.edu	37	chr16	81053723	81053723	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggtgacagtcagcttcagaGaaactgaggagaatgcagtc	13	7	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:81053723G>C	uc002ffx.2	+	6	1163	c.373G>C	c.(373-375)GAA>CAA	p.E125Q	CENPN_uc002ffw.3_Missense_Mutation_p.E125Q|CENPN_uc010vnl.1_Missense_Mutation_p.E125Q|CENPN_uc010vnm.1_Missense_Mutation_p.E105Q|CENPN_uc002ffy.3_Missense_Mutation_p.E125Q	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	125					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						CAGCTTCAGAGAAACTGAGGA	0.423													0	0	0	1	0	30	33										C	81053723	G	C	81053723	3	2	18	1	0	0	0	0	1	0	0	0	3238	943	33	1	391	1	CENPN	16	81053723	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	5363429	81053723	9301030	428	5002										
BCMO1	53630	broad.mit.edu	37	chr16	81303925	81303925	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aacagcctctaccagctcttCtacctggccaacctgaacca	5	17	3	1	rs141341532	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:81303925C>G	uc002fgn.1	+	7	1223	c.1005C>G	c.(1003-1005)TTC>TTG	p.F335L	BCMO1_uc010vnp.1_Missense_Mutation_p.F266L	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	335					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						ACCAGCTCTTCTACCTGGCCA	0.577													0	0	0	1	0	46	71										G	81303925	C	G	81303925	3	3	18	1	0	0	0	0	1	0	0	0	1384	912	32	1	1031	1	BCMO1	16	81303925	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	250202	81303925	9050828	429	5003										
ZCCHC14	23174	broad.mit.edu	37	chr16	87448115	87448115	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggtgaccagcggcggggccGaggggttcaggcaccgtctc	18	12	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:87448115G>A	uc002fjz.1	-	10	1124	c.1097C>T	c.(1096-1098)TCG>TTG	p.S366L	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.S142L	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	366					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		CGGCGGGGCCGAGGGGTTCAG	0.637													0	0	0	1	0	24	31										A	87448115	G	A	87448115	3	1	18	1	0	0	0	0	1	0	0	0	17580	1059	37	1	1768	1	ZCCHC14	16	87448115	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	6144190	87448115	2906638	430	5004										
KLHDC4	54758	broad.mit.edu	37	chr16	87741967	87741967	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cccgctcacctcagtcctccGcaccgctctcctctccgctg	6	23	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:87741967G>A	uc002fki.2	-	11	1599	c.1553C>T	c.(1552-1554)GCG>GTG	p.A518V	LOC100129637_uc002fkg.2_5'Flank|LOC100129637_uc002fke.2_5'Flank|KLHDC4_uc002fkh.1_RNA|KLHDC4_uc010cht.1_Missense_Mutation_p.R203W|KLHDC4_uc002fkj.2_Missense_Mutation_p.A487V|KLHDC4_uc002fkk.2_Missense_Mutation_p.A337V|KLHDC4_uc002fkl.2_Missense_Mutation_p.A461V	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	518										pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		TCAGTCCTCCGCACCGCTCTC	0.622													0	0	0	1	0	59	90										A	87741967	G	A	87741967	3	1	18	1	0	0	0	0	1	0	0	0	8358	1087	38	2	13	2	KLHDC4	16	87741967	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	293852	87741967	2612786	431	5005										
ZC3H18	124245	broad.mit.edu	37	chr16	88677720	88677720	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagaacagacagcgcgagcgCgagcgggagcgggagcggga	21	9	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:88677720C>G	uc002fky.2	+	8	1451	c.1251C>G	c.(1249-1251)CGC>CGG	p.R417R	ZC3H18_uc010voy.1_Silent_p.R300R|ZC3H18_uc010voz.1_Silent_p.R441R|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	417	Potential.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		agcgcgagcgcgagcgggagc	0													0	0	0	1	0	2	5										G	88677720	C	G	88677720	2	3	18	1	0	0	0	0	0	0	0	1	17565	755	27	4		4	ZC3H18	16	88677720	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	935753	88677720	1677033	432	5006										
CDT1	81620	broad.mit.edu	37	chr16	88870299	88870299	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgccccgggcccccccgcatCgcgccgcccaagctggcctg	12	23	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:88870299C>T	uc002flu.2	+	1	114	c.60C>T	c.(58-60)ATC>ATT	p.I20I		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	20	PIP-box K+4 motif.				DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		ccccccgcATCGCGCCGCCCA	0.572													0	0	0	1	0	13	23										T	88870299	C	T	88870299	2	4	18	1	0	0	0	0	0	0	0	1	3180	874	31	1		1	CDT1	16	88870299	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	192579	88870299	1484454	433	5007										
ANKRD11	29123	broad.mit.edu	37	chr16	89350394	89350394	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcccagctgtcctcccctttGaaatcaaaggatgaatcgga	8	12	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr16:89350394G>C	uc002fmx.1	-	9	3017	c.2556C>G	c.(2554-2556)TTC>TTG	p.F852L	ANKRD11_uc002fmy.1_Missense_Mutation_p.F852L|ANKRD11_uc002fnc.1_Missense_Mutation_p.F852L|ANKRD11_uc002fnb.1_Missense_Mutation_p.F809L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	852	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTCCCCTTTGAAATCAAAGG	0.488													0	0	0	1	0	48	59										C	89350394	G	C	89350394	3	2	18	1	0	0	0	0	1	0	0	0	639	1281	45	1	5455	1	ANKRD11	16	89350394	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	480095	89350394	1004359	434	5008										
MYO1C	4641	broad.mit.edu	37	chr17	1378124	1378124	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acctccttaaggttccggaaGagaaggtcattgtttttgtc	10	8	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:1378124G>T	uc002fsp.2	-	16	1918	c.1698C>A	c.(1696-1698)CTC>CTA	p.L566L	MYO1C_uc002fsn.2_Silent_p.L547L|MYO1C_uc002fso.2_Silent_p.L531L|MYO1C_uc010vqj.1_Silent_p.L531L|MYO1C_uc010vqk.1_Silent_p.L542L	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	566	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGTTCCGGAAGAGAAGGTCAT	0.637													1	0	2.17126e-26	1	2.29479e-26	42	7										T	1378124	G	T	1378124	2	4	18	1	0	0	0	0	0	0	0	1	10070	929	33	3		3	MYO1C	17	1378124	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		1378124	79817086	435	5009										
TP53	7157	broad.mit.edu	37	chr17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acaggcacaaacacgcacctCaaagctgttccgtcccagta	7	15	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	18	2										T	7577127	C	T	7577127	3	4	18	1	0	0	0	0	1	0	0	0	16378	835	29	1	475	1	TP53	17	7577127	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6199003	7577127	73618083	436	5010										
C17orf59	54785	broad.mit.edu	37	chr17	8092765	8092765	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aggggcagaaggcgggggtgGaggcgcgccgctcagacgga	22	9	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:8092765G>C	uc010vut.1	-	1	800	c.694C>G	c.(694-696)CCA>GCA	p.P232A		NM_017622	NP_060092	Q96GS4	CQ059_HUMAN	hypothetical protein LOC54785	232	Pro-rich.										0						GGCGGGGGTGGAGGCGCGCCG	0.682													0	0	0	1	0	6	2										C	8092765	G	C	8092765	3	2	18	1	0	0	0	0	1	0	0	0	1867	1174	41	1	383	1	C17orf59	17	8092765	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	515638	8092765	73102445	437	5011										
RAI1	10743	broad.mit.edu	37	chr17	17701534	17701534	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccgggaagccccccaggcctGacggcccagctgacccggcc	13	20	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:17701534G>A	uc002grm.2	+	3	5741	c.5272G>A	c.(5272-5274)GAC>AAC	p.D1758N	RAI1_uc002grn.1_Missense_Mutation_p.D1758N	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1758						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CCCCAGGCCTGACGGCCCAGC	0.697													0	0	0	1	0	9	0										A	17701534	G	A	17701534	3	1	18	1	0	0	0	0	1	0	0	0	13007	1290	45	1	5274	1	RAI1	17	17701534	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	9608769	17701534	63493676	438	5012										
TOP3A	7156	broad.mit.edu	37	chr17	18188594	18188594	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagcccggaggtcaggcttaGacatttcatagcccatggaa	11	11	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:18188594G>C	uc002gsx.1	-	15	1968	c.1739C>G	c.(1738-1740)TCT>TGT	p.S580C	TOP3A_uc010cpz.1_Missense_Mutation_p.S32C|TOP3A_uc010vxr.1_Missense_Mutation_p.S110C|TOP3A_uc002gsw.1_Missense_Mutation_p.S32C|TOP3A_uc010vxs.1_Missense_Mutation_p.S478C	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	580					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GTCAGGCTTAGACATTTCATA	0.522													0	0	0	1	0	42	8										C	18188594	G	C	18188594	3	2	18	1	0	0	0	0	1	0	0	0	16364	942	33	1	1286	1	TOP3A	17	18188594	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	487060	18188594	63006616	439	5013										
EFCAB5	374786	broad.mit.edu	37	chr17	28296332	28296332	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctggttaccagaggttgatGaaagaagtcacagaagacct	11	7	2	6			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:28296332G>A	uc002het.2	+	4	906	c.714G>A	c.(712-714)ATG>ATA	p.M238I	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Missense_Mutation_p.M182I|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.M117I|EFCAB5_uc010csf.2_Missense_Mutation_p.M117I	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	238							calcium ion binding			ovary(1)|skin(1)	2						AGAGGTTGATGAAAGAAGTCA	0.358													0	0	0	1	0	44	3										A	28296332	G	A	28296332	3	1	18	1	0	0	0	0	1	0	0	0	4938	1290	45	1	728	1	EFCAB5	17	28296332	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10107738	28296332	52898878	440	5014										
NF1	4763	broad.mit.edu	37	chr17	29554250	29554250	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcttaggaagagcagcacttCagaaaagagtgatggcactg	13	7	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:29554250C>T	uc002hgg.2	+	19	2599	c.2266C>T	c.(2266-2268)CAG>TAG	p.Q756*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q756*|NF1_uc010csn.1_Nonsense_Mutation_p.Q616*|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	756					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.Q756*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGCAGCACTTCAGAAAAGAGT	0.517			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	1	0	172	18										T	29554250	C	T	29554250	4	4	18	1	0	0	0	0	0	1	0	0	10356	827	29	1	2401	1	NF1	17	29554250	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1257918	29554250	51640960	441	5015										
SUZ12	23512	broad.mit.edu	37	chr17	30323823	30323823	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttctttttcccagcaaattGaagagttttctgatgttaat	6	6	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:30323823G>C	uc002hgs.2	+	15	2023	c.1801G>C	c.(1801-1803)GAA>CAA	p.E601Q	SUZ12_uc002hgt.2_Missense_Mutation_p.E578Q	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	601	VEFS-box.				negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				CCAGCAAATTGAAGAGTTTTC	0.299			T	JAZF1	endometrial stromal tumours								0	0	0	1	0	7	62										C	30323823	G	C	30323823	3	2	18	1	0	0	0	0	1	0	0	0	15413	1291	45	1	1859	1	SUZ12	17	30323823	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	769573	30323823	50871387	442	5016										
GPR179	440435	broad.mit.edu	37	chr17	36485624	36485624	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggtcttgtcttagtgccctCgactctggggctccttcact	11	13	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36485624C>T	uc002hpz.2	-	11	3849	c.3828G>A	c.(3826-3828)TCG>TCA	p.S1276S		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1276	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTAGTGCCCTCGACTCTGGGG	0.562													0	0	0	1	0	80	2										T	36485624	C	T	36485624	2	4	18	1	0	0	0	0	0	0	0	1	6674	871	31	1		1	GPR179	17	36485624	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6161801	36485624	44709586	443	5017			3	16		4	4	1459	C		2.596653e-06
GPR179	440435	broad.mit.edu	37	chr17	36486316	36486316	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgcatcctctgcgtccatctCattctccccagccctgcttt	5	18	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36486316C>T	uc002hpz.2	-	11	3157	c.3136G>A	c.(3136-3138)GAG>AAG	p.E1046K		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1046	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GCGTCCATCTCATTCTCCCCA	0.597													0	0	0	1	0	87	7										T	36486316	C	T	36486316	3	4	18	1	0	0	0	0	1	0	0	0	6674	835	29	1	3971	1	GPR179	17	36486316	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	692	36486316	44708894	444	5018			3	16		4	4	1459	C		2.596653e-06
GPR179	440435	broad.mit.edu	37	chr17	36486596	36486596	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtggaggtgggagatagcatCcttggctctcccaggccccc	14	13	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36486596C>T	uc002hpz.2	-	11	2877	c.2856G>A	c.(2854-2856)AGG>AGA	p.R952R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	952	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GAGATAGCATCCTTGGCTCTC	0.468													0	0	0	1	0	19	2										T	36486596	C	T	36486596	2	4	18	1	0	0	0	0	0	0	0	1	6674	854	30	1		1	GPR179	17	36486596	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	280	36486596	44708614	445	5019			3	16		4	4	1459	C		2.596653e-06
GPR179	440435	broad.mit.edu	37	chr17	36487082	36487082	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttcttggccagcttcctcctCagcagtgagtcaagaagagg	11	11	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:36487082C>T	uc002hpz.2	-	11	2391	c.2370G>A	c.(2368-2370)CTG>CTA	p.L790L		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	790	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GCTTCCTCCTCAGCAGTGAGT	0.657													0	0	0	1	0	17	2										T	36487082	C	T	36487082	2	4	18	1	0	0	0	0	0	0	0	1	6674	813	29	1		1	GPR179	17	36487082	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	486	36487082	44708128	446	5020			3	16		4	4	1459	C		2.596653e-06
MSL1	339287	broad.mit.edu	37	chr17	38289813	38289822	+	Frame_Shift_Del	DEL	AAAGAATTTT	AAAGAATTTT	-													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tattcagaggatcagggaacAaagaattttacagcgactgc							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:38289813_38289822delAAAGAATTTT	uc002hub.2	+	7	999_1008	c.980_989delAAAGAATTTT	c.(979-990)CAAAGAATTTTAfs	p.Q327fs	MSL1_uc002hua.3_Frame_Shift_Del_p.Q265fs|MSL1_uc002hud.2_Frame_Shift_Del_p.Q67fs	NM_001012241	NP_001012241	Q68DK7	MSL1_HUMAN	hampin	528_531					histone H4-K16 acetylation	MSL complex					0						ATCAGGGAACAAAGAATTTTACAGCGACTG	0.39																		9	3	---	---								-	38289822	AAAGAATTTT	-	38289813	7	5	18	1	0	1	0	1	0	0	0	0	9877	130	5	0	816	0	MSL1	17	38289813	Frame_Shift_Del	DEL	AAAGAATTTT	TCGA-BT-A3PH-01A-11D-A21Z-08	1802731	38289813	42905397	447	5021										
KRTAP4-12	83755	broad.mit.edu	37	chr17	39279805	39279805	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcacagcacaaggggcggggGcaggtggagatgacacaggt	19	8	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:39279805G>A	uc002hwa.2	-	1	615	c.570C>T	c.(568-570)TGC>TGT	p.C190C		NM_031854	NP_114060	Q9BQ66	KR412_HUMAN	keratin associated protein 4-12	190						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGGGGCGGGGGCAGGTGGAGA	0.478													0	0	0	1	0	3	36										A	39279805	G	A	39279805	2	1	18	1	0	0	0	0	0	0	0	1	8550	1195	42	2		2	KRTAP4-12	17	39279805	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	989992	39279805	41915405	448	5022										
BRCA1	672	broad.mit.edu	37	chr17	41245834	41245834	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agattctttttcgagtgattCtattgggttaggatttttct	9	4	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:41245834C>T	uc002icq.2	-	10	1946	c.1714G>A	c.(1714-1716)GAA>AAA	p.E572K	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.E501K|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.E525K|BRCA1_uc002ict.2_Missense_Mutation_p.E572K|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.E572K|BRCA1_uc002ide.1_Missense_Mutation_p.E403K|BRCA1_uc010cyy.1_Missense_Mutation_p.E572K|BRCA1_uc010whs.1_Missense_Mutation_p.E572K|BRCA1_uc010cyz.2_Missense_Mutation_p.E525K|BRCA1_uc010cza.2_Missense_Mutation_p.E546K|BRCA1_uc010wht.1_Missense_Mutation_p.E276K	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	572					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCGAGTGATTCTATTGGGTTA	0.338			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	1	0	90	4										T	41245834	C	T	41245834	3	4	18	1	0	0	0	0	1	0	0	0	1498	922	32	1	4003	1	BRCA1	17	41245834	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1966029	41245834	39949376	449	5023										
SCRN2	90507	broad.mit.edu	37	chr17	45915767	45915767	+	Frame_Shift_Del	DEL	G	G	-													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaaagtgggggacagcacctGgggggcctgggccaccccca							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:45915767delG	uc002imd.2	-	7	1114	c.988delC	c.(988-990)CAGfs	p.Q330fs	SCRN2_uc002imc.2_Frame_Shift_Del_p.Q338fs|SCRN2_uc002imf.2_Frame_Shift_Del_p.Q330fs|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	330					proteolysis		dipeptidase activity			ovary(1)	1						GACAGCACCTGGGGGGCCTGG	0.577																		245	59	---	---								-	45915767	G	-	45915767	7	5	18	1	0	1	0	1	0	0	0	0	13939	1357	47	0	315	0	SCRN2	17	45915767	Frame_Shift_Del	DEL	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4669933	45915767	35279443	450	5024										
TEX14	56155	broad.mit.edu	37	chr17	56646611	56646611	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcatcaatgtgatgctgtgaGaaggcttctactagttttta	9	6	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:56646611G>C	uc010dcz.1	-	27	4084	c.3966C>G	c.(3964-3966)TTC>TTG	p.F1322L	TEX14_uc002iwr.1_Missense_Mutation_p.F1316L|TEX14_uc002iws.1_Missense_Mutation_p.F1276L|TEX14_uc010dda.1_Missense_Mutation_p.F1056L	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1322						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATGCTGTGAGAAGGCTTCTA	0.418													0	0	0	1	0	65	13										C	56646611	G	C	56646611	3	2	18	1	0	0	0	0	1	0	0	0	15775	933	33	1	555	1	TEX14	17	56646611	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	10730844	56646611	24548599	451	5025										
HELZ	9931	broad.mit.edu	37	chr17	65141996	65141996	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttgccctcatagaaaagctCagaggtataactgcagtaaa	8	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:65141996C>G	uc010wqk.1	-	21	2822	c.2635G>C	c.(2635-2637)GAG>CAG	p.E879Q	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.E878Q	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TAGAAAAGCTCAGAGGTATAA	0.373													0	0	0	1	0	20	35										G	65141996	C	G	65141996	3	3	18	1	0	0	0	0	1	0	0	0	7049	835	29	1	3248	1	HELZ	17	65141996	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	8495385	65141996	16053214	452	5026										
COG1	9382	broad.mit.edu	37	chr17	71197805	71197805	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagctgcactcagttcttttCatggccagactctgccagtc	8	13	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:71197805C>G	uc002jjg.2	+	7	1875	c.1839C>G	c.(1837-1839)TTC>TTG	p.F613L	COG1_uc002jjh.2_Missense_Mutation_p.F613L|COG1_uc002jjf.1_Missense_Mutation_p.F613L	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	613					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			CAGTTCTTTTCATGGCCAGAC	0.547													0	0	0	1	0	57	6										G	71197805	C	G	71197805	3	3	18	1	0	0	0	0	1	0	0	0	3657	825	29	1	1865	1	COG1	17	71197805	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6055809	71197805	9997405	453	5027										
MIF4GD	57409	broad.mit.edu	37	chr17	73262901	73262901	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcccggaactcaatgatctCcagcagcagcagctgggcca	11	15	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:73262901C>G	uc002jnr.2	-	6	718	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	MIF4GD_uc002jno.2_Missense_Mutation_p.E238Q|MIF4GD_uc002jnp.2_Missense_Mutation_p.E231Q|MIF4GD_uc002jnq.2_Missense_Mutation_p.E238Q			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	197	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			TCAATGATCTCCAGCAGCAGC	0.592													0	0	0	1	0	106	7										G	73262901	C	G	73262901	3	3	18	1	0	0	0	0	1	0	0	0	9584	864	30	1	83	1	MIF4GD	17	73262901	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2065096	73262901	7932309	454	5028										
ACOX1	51	broad.mit.edu	37	chr17	73949633	73949633	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctcccacaaggaaggacctGacaaacaccatggtcccgta	8	14	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:73949633G>C	uc002jqf.2	-	7	1133	c.843C>G	c.(841-843)GTC>GTG	p.V281V	ACOX1_uc010wsq.1_Silent_p.V243V|ACOX1_uc002jqe.2_Silent_p.V281V|ACOX1_uc010wsr.1_Silent_p.V213V	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	281					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						GGAAGGACCTGACAAACACCA	0.527													0	0	0	1	0	94	14										C	73949633	G	C	73949633	2	2	18	1	0	0	0	0	0	0	0	1	158	1277	45	1		1	ACOX1	17	73949633	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	686732	73949633	7245577	455	5029										
SRP68	6730	broad.mit.edu	37	chr17	74057619	74057619	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agctttccattcttgatgttCaaaacgtagcattcctgaga	7	9	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:74057619C>G	uc002jqk.1	-	5	633	c.598G>C	c.(598-600)GAA>CAA	p.E200Q	SRP68_uc010wsu.1_Missense_Mutation_p.E99Q|SRP68_uc002jql.1_Missense_Mutation_p.E162Q	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	200					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TCTTGATGTTCAAAACGTAGC	0.433													0	0	0	1	0	76	8										G	74057619	C	G	74057619	3	3	18	1	0	0	0	0	1	0	0	0	15155	835	29	1	1333	1	SRP68	17	74057619	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	107986	74057619	7137591	456	5030										
MGAT5B	146664	broad.mit.edu	37	chr17	74900408	74900408	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcaccgagtgctccttcctCatctacctcagtgaggtcga	10	14	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:74900408C>T	uc002jti.2	+	5	730	c.627C>T	c.(625-627)CTC>CTT	p.L209L	MGAT5B_uc002jth.2_Silent_p.L198L	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	198	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GCTCCTTCCTCATCTACCTCA	0.667													0	0	0	1	0	19	1										T	74900408	C	T	74900408	2	4	18	1	0	0	0	0	0	0	0	1	9549	813	29	1		1	MGAT5B	17	74900408	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	842789	74900408	6294802	457	5031										
SYNGR2	9144	broad.mit.edu	37	chr17	76167833	76167833	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cctgcagggtgtgctggcctCcctggcctaccagcgctaca	12	16	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr17:76167833C>T	uc002juu.1	+	4	518	c.491C>T	c.(490-492)TCC>TTC	p.S164F	SYNGR2_uc002jut.2_Missense_Mutation_p.P194S|SYNGR2_uc002juv.1_Silent_p.L117L|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	164	MARVEL.|Helical; (Potential).					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			GTGCTGGCCTCCCTGGCCTAC	0.652													0	0	0	1	0	94	15										T	76167833	C	T	76167833	3	4	18	1	0	0	0	0	1	0	0	0	15446	855	30	1	505	1	SYNGR2	17	76167833	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1267425	76167833	5027377	458	5032										
LPIN2	9663	broad.mit.edu	37	chr18	2937747	2937747	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tttggattctgagggcgcctCcgctaaggctgcgttgggaa	15	9	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:2937747C>G	uc002klo.2	-	7	1350	c.1111G>C	c.(1111-1113)GAG>CAG	p.E371Q		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	371					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GAGGGCGCCTCCGCTAAGGCT	0.483													0	0	0	1	0	45	74										G	2937747	C	G	2937747	3	3	18	1	0	0	0	0	1	0	0	0	8919	864	30	1	1635	1	LPIN2	18	2937747	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		2937747	75139501	459	5033										
LAMA1	284217	broad.mit.edu	37	chr18	6961983	6961983	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcactccataggaatttctGagtaagtcaaaggttgatct	8	8	4	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:6961983G>C	uc002knm.2	-	52	7507	c.7413C>G	c.(7411-7413)CTC>CTG	p.L2471L	LAMA1_uc002knl.2_5'UTR|LAMA1_uc010wzj.1_Silent_p.L1947L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2471	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAATTTCTGAGTAAGTCAA	0.403													0	0	0	1	0	83	103										C	6961983	G	C	6961983	2	2	18	1	0	0	0	0	0	0	0	1	8605	1277	45	1		1	LAMA1	18	6961983	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4024236	6961983	71115265	460	5034										
PTPRM	5797	broad.mit.edu	37	chr18	8244134	8244134	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atggtgaactcaatggacaaGagctatgctgagcagggcac	13	8	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:8244134G>C	uc002knn.3	+	15	2882	c.2379G>C	c.(2377-2379)AAG>AAC	p.K793N	PTPRM_uc010dkv.2_Missense_Mutation_p.K793N|PTPRM_uc010wzl.1_Missense_Mutation_p.K580N	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	793	Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CAATGGACAAGAGCTATGCTG	0.463													0	0	0	1	0	74	90										C	8244134	G	C	8244134	3	2	18	1	0	0	0	0	1	0	0	0	12806	933	33	1	2437	1	PTPRM	18	8244134	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1282151	8244134	69833114	461	5035										
NPC1	4864	broad.mit.edu	37	chr18	21120457	21120457	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatccaatatctactttgttCaggactgcgatgctgaatga	8	8	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:21120457C>G	uc002kum.3	-	17	2833	c.2559G>C	c.(2557-2559)CTG>CTC	p.L853L	NPC1_uc010xaz.1_Silent_p.L586L|NPC1_uc010xba.1_Silent_p.L698L	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	853	Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CTACTTTGTTCAGGACTGCGA	0.358													0	0	0	1	0	22	51										G	21120457	C	G	21120457	2	3	18	1	0	0	0	0	0	0	0	1	10570	813	29	1		1	NPC1	18	21120457	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	12876323	21120457	56956791	462	5036										
OSBPL1A	114876	broad.mit.edu	37	chr18	21914240	21914240	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gttctgttgttttgccttctCttgctgctgctaaaagtaat	8	8	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:21914240C>T	uc002kve.2	-	6	623	c.449G>A	c.(448-450)AGA>AAA	p.R150K		NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	150					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TTTGCCTTCTCTTGCTGCTGC	0.363													0	0	0	1	0	30	51										T	21914240	C	T	21914240	3	4	18	1	0	0	0	0	1	0	0	0	11277	913	32	1	2495	1	OSBPL1A	18	21914240	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	793783	21914240	56163008	463	5037										
CHST9	83539	broad.mit.edu	37	chr18	24496276	24496276	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atagtccaagtaataaaagtCatagattaattgtctctcag	6	6	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:24496276C>T	uc002kwd.2	-	5	1477	c.1279G>A	c.(1279-1281)GAC>AAC	p.D427N	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.D342N|CHST9_uc002kwe.2_Missense_Mutation_p.D427N	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	427	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					TAATAAAAGTCATAGATTAAT	0.313													0	0	0	1	0	30	54										T	24496276	C	T	24496276	3	4	18	1	0	0	0	0	1	0	0	0	3411	826	29	1	56	1	CHST9	18	24496276	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2582036	24496276	53580972	464	5038										
C18orf34	374864	broad.mit.edu	37	chr18	30554571	30554571	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtctggaagttggccagcctCatctggctgaagaggaccac	13	11	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:30554571C>T	uc002kxn.2	-	21	2605	c.2463G>A	c.(2461-2463)ATG>ATA	p.M821I	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Missense_Mutation_p.M285I|C18orf34_uc010xbr.1_Missense_Mutation_p.M845I|C18orf34_uc010dmf.1_Missense_Mutation_p.M141I|C18orf34_uc002kxo.2_Missense_Mutation_p.M783I|C18orf34_uc002kxp.2_Missense_Mutation_p.M821I	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	821										ovary(1)	1						TGGCCAGCCTCATCTGGCTGA	0.493													0	0	0	1	0	51	45										T	30554571	C	T	30554571	3	4	18	1	0	0	0	0	1	0	0	0	1902	826	29	1	148	1	C18orf34	18	30554571	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6058295	30554571	47522677	465	5039										
C18orf34	374864	broad.mit.edu	37	chr18	30791874	30791874	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	actcacttgggtatcttgaaGagttttttgtcttacagcaa	8	7	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:30791874G>C	uc002kxn.2	-	19	2366	c.2224C>G	c.(2224-2226)CTT>GTT	p.L742V	C18orf34_uc010dme.1_Missense_Mutation_p.L256V|C18orf34_uc010xbr.1_Missense_Mutation_p.L742V|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.L704V|C18orf34_uc002kxp.2_Missense_Mutation_p.L742V	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	742										ovary(1)	1						GTATCTTGAAGAGTTTTTTGT	0.328													0	0	0	1	0	22	29										C	30791874	G	C	30791874	3	2	18	1	0	0	0	0	1	0	0	0	1902	942	33	1	395	1	C18orf34	18	30791874	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	237303	30791874	47285374	466	5040										
PHLPP1	23239	broad.mit.edu	37	chr18	60645778	60645778	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgctgtggtggtgcagctcaGtgtcactgaggacagcttct	14	10	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:60645778G>T	uc002lis.2	+	18	2910	c.2732G>T	c.(2731-2733)AGT>ATT	p.S911I		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1423					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						GTGCAGCTCAGTGTCACTGAG	0.632													1	0	9.05144e-12	1	9.29403e-12	10	13										T	60645778	G	T	60645778	3	4	18	1	0	0	0	0	1	0	0	0	11854	1029	36	4	4334	4	PHLPP1	18	60645778	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	29853904	60645778	17431470	467	5041										
ZNF236	7776	broad.mit.edu	37	chr18	74583695	74583695	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttataaccggaatatcgacaGaagtggattcacgtattcgt	9	7	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr18:74583695G>A	uc002lmi.2	+	5	773	c.575G>A	c.(574-576)AGA>AAA	p.R192K	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.R192K	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	192					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AATATCGACAGAAGTGGATTC	0.418													0	0	0	1	0	70	86										A	74583695	G	A	74583695	3	1	18	1	0	0	0	0	1	0	0	0	17786	942	33	1	593	1	ZNF236	18	74583695	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	13937917	74583695	3493553	468	5042										
ZFR2	23217	broad.mit.edu	37	chr19	3834946	3834946	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gttgtgcagtatagctggccCccacagtgggcaggggaagg	17	9	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:3834946C>T	uc002lyw.2	-	2	101	c.89G>A	c.(88-90)GGG>GAG	p.G30E	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	30						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		ATAGCTGGCCCCCACAGTGGG	0.637													0	0	0	1	0	11	5										T	3834946	C	T	3834946	3	4	18	1	0	0	0	0	1	0	0	0	17657	623	22	2	2802	2	ZFR2	19	3834946	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		3834946	55294037	469	5043										
TMEM146	257062	broad.mit.edu	37	chr19	5745940	5745940	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccagggcatgttcaagtactCagatcaccccctcaaccgga	8	15	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:5745940C>G	uc002mda.2	+	9	735	c.674C>G	c.(673-675)TCA>TGA	p.S225*	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	225	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTCAAGTACTCAGATCACCCC	0.468													0	0	0	1	0	85	249										G	5745940	C	G	5745940	4	3	18	1	0	0	0	0	0	1	0	0	16057	838	29	1	708	1	TMEM146	19	5745940	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1910994	5745940	53383043	470	5044										
NDUFA7	4701	broad.mit.edu	37	chr19	8386222	8386222	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cagttccgcagccgctggatGagacgggtggcggacgccat	16	12	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:8386222G>A	uc002mjm.1	-	1	59	c.21C>T	c.(19-21)CTC>CTT	p.L7L	RPS28_uc002mjn.2_5'Flank	NM_005001	NP_004992	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	7					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	GCCGCTGGATGAGACGGGTGG	0.716													0	0	0	1	0	4	4										A	8386222	G	A	8386222	2	1	18	1	0	0	0	0	0	0	0	1	10270	1277	45	1		1	NDUFA7	19	8386222	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2640282	8386222	50742761	471	5045										
MUC16	94025	broad.mit.edu	37	chr19	9067806	9067806	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgtggtcttcactaggccaGaggtggggagtgaagtcaga	16	7	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:9067806G>C	uc002mkp.2	-	3	19844	c.19640C>G	c.(19639-19641)TCT>TGT	p.S6547C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6549	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACTAGGCCAGAGGTGGGGAG	0.488													0	0	0	1	0	28	17										C	9067806	G	C	9067806	3	2	18	1	0	0	0	0	1	0	0	0	9973	942	33	1	24211	1	MUC16	19	9067806	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	681584	9067806	50061177	472	5046										
MUC16	94025	broad.mit.edu	37	chr19	9071775	9071775	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tagaagagttgacccctgtaCtggagacctcagtaatagta	10	8	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:9071775C>G	uc002mkp.2	-	3	15875	c.15671G>C	c.(15670-15672)AGT>ACT	p.S5224T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5226	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACCCCTGTACTGGAGACCTC	0.507													0	0	0	1	0	88	53										G	9071775	C	G	9071775	3	3	18	1	0	0	0	0	1	0	0	0	9973	565	20	4	28180	4	MUC16	19	9071775	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3969	9071775	50057208	473	5047										
YIPF2	78992	broad.mit.edu	37	chr19	11034009	11034009	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcaaggtaggggacagcgcGatgtttgagggcagagatgt	19	5	0	2	rs151256467	byFrequency	TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:11034009G>A	uc002mqb.2	-	9	1033	c.909C>T	c.(907-909)ATC>ATT	p.I303I	YIPF2_uc002mqc.2_Silent_p.I303I	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	303	Lumenal (Potential).					integral to membrane|transport vesicle					0						GGGACAGCGCGATGTTTGAGG	0.627													0	0	0	1	0	47	140										A	11034009	G	A	11034009	2	1	18	1	0	0	0	0	0	0	0	1	17475	1048	37	1		1	YIPF2	19	11034009	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1962234	11034009	48094974	474	5048										
ZNF700	90592	broad.mit.edu	37	chr19	12060829	12060829	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctgtaaattctcttcttttCaaatacatgaaaggaagcac	5	8	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:12060829C>G	uc002msu.2	+	4	2116	c.1990C>G	c.(1990-1992)CAA>GAA	p.Q664E	ZNF700_uc010xme.1_Missense_Mutation_p.Q682E|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	664	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCTTCTTTTCAAATACATGA	0.398													0	0	0	1	0	26	27										G	12060829	C	G	12060829	3	3	18	1	0	0	0	0	1	0	0	0	18101	827	29	1	2004	1	ZNF700	19	12060829	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1026820	12060829	47068154	475	5049										
LPHN1	22859	broad.mit.edu	37	chr19	14273746	14273746	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcagtgtgtaggggttcagCtggctcaccaccagccgccc	13	15	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:14273746C>G	uc010xnn.1	-	6	1178	c.882G>C	c.(880-882)CAG>CAC	p.Q294H	LPHN1_uc010xno.1_Missense_Mutation_p.Q289H|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	294	Olfactomedin-like.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						AGGGGTTCAGCTGGCTCACCA	0.632													0	0	0	1	0	11	36										G	14273746	C	G	14273746	3	3	18	1	0	0	0	0	1	0	0	0	8915	796	28	4	3618	4	LPHN1	19	14273746	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2212917	14273746	44855237	476	5050										
JAK3	3718	broad.mit.edu	37	chr19	17953847	17953847	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggctctcacctgacagtcttCagcagctctcccggccgctg	10	17	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:17953847C>T	uc002nhn.3	-	5	655	c.555G>A	c.(553-555)CTG>CTA	p.L185L	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Silent_p.L185L|JAK3_uc010xpx.1_Silent_p.L185L|JAK3_uc010xpy.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	185	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGACAGTCTTCAGCAGCTCTC	0.672		2	Mis		acute megakaryocytic leukemia|								0	0	0	1	0	42	28										T	17953847	C	T	17953847	2	4	18	1	0	0	0	0	0	0	0	1	7939	813	29	1		1	JAK3	19	17953847	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	3680101	17953847	41175136	477	5051										
UPF1	5976	broad.mit.edu	37	chr19	18968269	18968269	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcctgcaggtccagtaccgGatgcaccctgcactcagcgc	11	17	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:18968269G>C	uc002nkg.2	+	15	2417	c.2142G>C	c.(2140-2142)CGG>CGC	p.R714R	UPF1_uc002nkf.2_Silent_p.R703R|UPF1_uc002nkh.2_5'Flank	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	714				R->A: Impairs ATPase activity and ATP binding.	cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TCCAGTACCGGATGCACCCTG	0.647													0	0	0	1	0	22	16										C	18968269	G	C	18968269	2	2	18	1	0	0	0	0	0	0	0	1	17000	1161	41	1		1	UPF1	19	18968269	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1014422	18968269	40160714	478	5052										
ZNF626	199777	broad.mit.edu	37	chr19	20807417	20807417	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcttcacatttgtagggtctCtctccagtatgaattttctt	6	9	5	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:20807417C>G	uc002npb.1	-	4	1416	c.1266G>C	c.(1264-1266)GAG>GAC	p.E422D	ZNF626_uc002npc.1_Missense_Mutation_p.E346D	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TGTAGGGTCTCTCTCCAGTAT	0.378													0	0	0	1	0	46	35										G	20807417	C	G	20807417	3	3	18	1	0	0	0	0	1	0	0	0	18047	912	32	1	324	1	ZNF626	19	20807417	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1839148	20807417	38321566	479	5053										
ZNF91	7644	broad.mit.edu	37	chr19	23544674	23544674	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttctcttcagtatgagttatCttatgattagcaagggttga	9	5	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:23544674C>G	uc002nre.2	-	4	1220	c.1107G>C	c.(1105-1107)AAG>AAC	p.K369N	ZNF91_uc010xrj.1_Missense_Mutation_p.K337N	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	369	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TATGAGTTATCTTATGATTAG	0.358													0	0	0	1	0	15	45										G	23544674	C	G	23544674	3	3	18	1	0	0	0	0	1	0	0	0	18197	912	32	1	2472	1	ZNF91	19	23544674	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2737257	23544674	35584309	480	5054										
ZNF599	148103	broad.mit.edu	37	chr19	35251122	35251122	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgcatgtgtaagggttattcCttgcatcagtcatggggtct	12	7	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35251122C>G	uc010edn.1	-	4	972	c.584G>C	c.(583-585)AGG>ACG	p.R195T	ZNF599_uc010edm.1_Missense_Mutation_p.R158T	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			AGGGTTATTCCTTGCATCAGT	0.493													0	0	0	1	0	37	83										G	35251122	C	G	35251122	3	3	18	1	0	0	0	0	1	0	0	0	18026	681	24	4	1186	4	ZNF599	19	35251122	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	11706448	35251122	23877861	481	5055			4	17		3	3	153	C		3.408887e-06
ZNF599	148103	broad.mit.edu	37	chr19	35251243	35251243	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atcatctggctccaaatcatCatgtttataactcaacttct	3	11	6	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35251243C>T	uc010edn.1	-	4	851	c.463G>A	c.(463-465)GAT>AAT	p.D155N	ZNF599_uc010edm.1_Missense_Mutation_p.D118N	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TCCAAATCATCATGTTTATAA	0.438													0	0	0	1	0	34	127										T	35251243	C	T	35251243	3	4	18	1	0	0	0	0	1	0	0	0	18026	826	29	1	1307	1	ZNF599	19	35251243	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	121	35251243	23877740	482	5056			4	17		3	3	153	C		3.408887e-06
ZNF599	148103	broad.mit.edu	37	chr19	35251274	35251274	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcaacttctcagggcatatCtctttgtgggggtttgttcc	10	10	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35251274C>G	uc010edn.1	-	4	820	c.432G>C	c.(430-432)GAG>GAC	p.E144D	ZNF599_uc010edm.1_Missense_Mutation_p.E107D	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CAGGGCATATCTCTTTGTGGG	0.448													0	0	0	1	0	44	161										G	35251274	C	G	35251274	3	3	18	1	0	0	0	0	1	0	0	0	18026	912	32	1	1338	1	ZNF599	19	35251274	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	31	35251274	23877709	483	5057			4	17		3	3	153	C		3.408887e-06
GRAMD1A	57655	broad.mit.edu	37	chr19	35502453	35502453	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctggcagaatgcactgcttGaaaaggtgggcctgggtgag	16	7	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:35502453G>C	uc010xse.1	+	7	738	c.601G>C	c.(601-603)GAA>CAA	p.E201Q	GRAMD1A_uc002nxi.1_Missense_Mutation_p.E288Q|GRAMD1A_uc002nxk.2_Missense_Mutation_p.E194Q|GRAMD1A_uc002nxl.2_Missense_Mutation_p.L4F|GRAMD1A_uc010xsf.1_Missense_Mutation_p.E206Q|GRAMD1A_uc002nxm.1_5'Flank	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	201						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCACTGCTTGAAAAGGTGGG	0.627													0	0	0	1	0	30	81										C	35502453	G	C	35502453	3	2	18	1	0	0	0	0	1	0	0	0	6747	1291	45	1	627	1	GRAMD1A	19	35502453	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	251179	35502453	23626530	484	5058										
ZNF781	163115	broad.mit.edu	37	chr19	38161042	38161042	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctttaaatacattgcatttCtttgcattaaaatttgtctg	4	6	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:38161042C>G	uc002ogy.2	-	4	750	c.8G>C	c.(7-9)AGA>ACA	p.R3T	ZNF781_uc002ogz.2_5'UTR	NM_152605	NP_689818	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATTGCATTTCTTTGCATTAA	0.343													0	0	0	1	0	27	81										G	38161042	C	G	38161042	3	3	18	1	0	0	0	0	1	0	0	0	18151	913	32	1	979	1	ZNF781	19	38161042	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2658589	38161042	20967941	485	5059										
SERTAD1	29950	broad.mit.edu	37	chr19	40929372	40929372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tgccaccgctgtgtggccagGatctagccaccaggagtcga	13	13	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:40929372G>A	uc002ont.3	-	2	241	c.82C>T	c.(82-84)CCT>TCT	p.P28S		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	28					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTGTGGCCAGGATCTAGCCAC	0.567													0	0	0	1	0	48	29										A	40929372	G	A	40929372	3	1	18	1	0	0	0	0	1	0	0	0	14120	1174	41	1	632	1	SERTAD1	19	40929372	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2768330	40929372	18199611	486	5060										
CYP2F1	1572	broad.mit.edu	37	chr19	41628036	41628036	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcttcctcaccaagatggcaGaggtaatccctacctggaaa	9	12	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:41628036G>C	uc002opu.1	+	6	876	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	CYP2F1_uc010xvw.1_Missense_Mutation_p.E60Q|CYP2F1_uc010xvv.1_Missense_Mutation_p.E274Q|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	274					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CAAGATGGCAGAGGTAATCCC	0.602													0	0	0	1	0	32	21										C	41628036	G	C	41628036	3	2	18	1	0	0	0	0	1	0	0	0	4171	943	33	1	838	1	CYP2F1	19	41628036	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	698664	41628036	17500947	487	5061										
PLAUR	5329	broad.mit.edu	37	chr19	44156432	44156432	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gggcctcggcagtcaatgagGaaagtctcttcagaggagca	14	9	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:44156432G>C	uc002oxf.1	-	6	929	c.699C>G	c.(697-699)TTC>TTG	p.F233L	PLAUR_uc002oxd.1_Missense_Mutation_p.F233L|PLAUR_uc002oxe.1_Missense_Mutation_p.F228L|PLAUR_uc002oxg.1_Missense_Mutation_p.F188L	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	233	UPAR/Ly6 3.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	AGTCAATGAGGAAAGTCTCTT	0.572											OREG0025532	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	24	62										C	44156432	G	C	44156432	3	2	18	1	0	0	0	0	1	0	0	0	12023	1165	41	1	412	1	PLAUR	19	44156432	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2528396	44156432	14972551	488	5062										
PVR	5817	broad.mit.edu	37	chr19	45164564	45164564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctcctatttccccaggtacaGagcatgccagcgcctcagct	8	16	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:45164564G>C	uc002ozm.2	+	7	1455	c.1156G>C	c.(1156-1158)GAG>CAG	p.E386Q	PVR_uc010xxb.1_Missense_Mutation_p.E333Q|PVR_uc010xxc.1_Missense_Mutation_p.E341Q|PVR_uc002ozn.2_Missense_Mutation_p.E331Q	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	386	Cytoplasmic (Potential).				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		CCCAGGTACAGAGCATGCCAG	0.547													0	0	0	1	0	41	33										C	45164564	G	C	45164564	3	2	18	1	0	0	0	0	1	0	0	0	12837	943	33	1	1211	1	PVR	19	45164564	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1008132	45164564	13964419	489	5063										
PRKD2	25865	broad.mit.edu	37	chr19	47181774	47181774	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgaggctgacgtacatgatCacgcccactgaccacatgtc	9	14	1	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:47181774C>T	uc002pfh.2	-	17	2559	c.2217G>A	c.(2215-2217)GTG>GTA	p.V739V	PRKD2_uc002pfd.2_Silent_p.V113V|PRKD2_uc010eks.2_Silent_p.V142V|PRKD2_uc010ekt.2_Silent_p.V6V|PRKD2_uc002pfe.2_Silent_p.V259V|PRKD2_uc002pff.2_Silent_p.V259V|PRKD2_uc002pfg.2_Silent_p.V582V|PRKD2_uc002pfi.2_Silent_p.V739V|PRKD2_uc002pfj.2_Silent_p.V739V|PRKD2_uc010xye.1_Silent_p.V739V|PRKD2_uc002pfk.2_Silent_p.V582V	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	739	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CGTACATGATCACGCCCACTG	0.627													0	0	0	1	0	57	56										T	47181774	C	T	47181774	2	4	18	1	0	0	0	0	0	0	0	1	12519	813	29	1		1	PRKD2	19	47181774	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2017210	47181774	11947209	490	5064										
PRKD2	25865	broad.mit.edu	37	chr19	47204090	47204090	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tccctcgccttcctcctcctCactggcgtggagcgcattct	8	18	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:47204090C>T	uc002pfh.2	-	8	1429	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K	PRKD2_uc002pfg.2_Missense_Mutation_p.E206K|PRKD2_uc002pfi.2_Missense_Mutation_p.E363K|PRKD2_uc002pfj.2_Missense_Mutation_p.E363K|PRKD2_uc010xye.1_Missense_Mutation_p.E363K|PRKD2_uc002pfk.2_Missense_Mutation_p.E206K	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	363					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity	p.E363E(1)		ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		TCCTCCTCCTCACTGGCGTGG	0.587													0	0	0	1	0	35	34										T	47204090	C	T	47204090	3	4	18	1	0	0	0	0	1	0	0	0	12519	835	29	1	1597	1	PRKD2	19	47204090	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	22316	47204090	11924893	491	5065										
CYTH2	9266	broad.mit.edu	37	chr19	48973714	48973714	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcctgcgggaggagctcagtGaagccatgagcgaggtggag	19	8	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:48973714G>A	uc002pjj.3	+	2	424	c.124G>A	c.(124-126)GAA>AAA	p.E42K	uc002pjg.2_5'Flank|CYTH2_uc010xzr.1_Missense_Mutation_p.E42K|CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	42	Potential.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GGAGCTCAGTGAAGCCATGAG	0.677													0	0	0	1	0	18	80										A	48973714	G	A	48973714	3	1	18	1	0	0	0	0	1	0	0	0	4204	1291	45	1	130	1	CYTH2	19	48973714	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1769624	48973714	10155269	492	5066										
LMTK3	114783	broad.mit.edu	37	chr19	49000753	49000753	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggggggtccccgtctccgctGagtgccgtgtctccgccggc	16	16	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49000753G>A	uc002pjk.2	-	12	3660	c.3660C>T	c.(3658-3660)CTC>CTT	p.L1220L		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CGTCTCCGCTGAGTGCCGTGT	0.716													0	0	0	1	0	8	42										A	49000753	G	A	49000753	2	1	18	1	0	0	0	0	0	0	0	1	8860	1277	45	1		1	LMTK3	19	49000753	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	27039	49000753	10128230	493	5067										
BCAT2	587	broad.mit.edu	37	chr19	49300454	49300454	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atgggtgggcttacccccatCttcgtgggtccagtagacaa	12	11	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49300454C>G	uc002pkr.2	-	7	869	c.832G>C	c.(832-834)GAT>CAT	p.D278H	BCAT2_uc002pkp.2_Missense_Mutation_p.D238H|BCAT2_uc002pkq.3_Missense_Mutation_p.D238H|BCAT2_uc002pks.2_Missense_Mutation_p.D238H|BCAT2_uc002pkt.2_Missense_Mutation_p.D186H|BCAT2_uc010emh.1_Missense_Mutation_p.D278H|BCAT2_uc010emi.1_Missense_Mutation_p.D186H	NM_001190	NP_001181	O15382	BCAT2_HUMAN	branched chain aminotransferase 2, mitochondrial	278						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			ovary(1)	1		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	TTACCCCCATCTTCGTGGGTC	0.607													0	0	0	1	0	16	17										G	49300454	C	G	49300454	3	3	18	1	0	0	0	0	1	0	0	0	1355	913	32	1	366	1	BCAT2	19	49300454	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	299701	49300454	9828529	494	5068										
ALDH16A1	126133	broad.mit.edu	37	chr19	49965030	49965030	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gcctcccagcctggaatccgGaaggtggccttctgcggagc	14	14	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49965030G>A	uc002pnt.2	+	6	848	c.732G>A	c.(730-732)CGG>CGA	p.R244R	ALDH16A1_uc010yar.1_Silent_p.R244R|ALDH16A1_uc010yas.1_Silent_p.R79R|ALDH16A1_uc010yat.1_Silent_p.R81R	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	244							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CTGGAATCCGGAAGGTGGCCT	0.711													0	0	0	1	0	6	17										A	49965030	G	A	49965030	2	1	18	1	0	0	0	0	0	0	0	1	488	1161	41	1		1	ALDH16A1	19	49965030	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	664576	49965030	9163953	495	5069										
ALDH16A1	126133	broad.mit.edu	37	chr19	49965915	49965915	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggggcggcttcggagtggccGagggctggatggggccgtgg	24	8	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:49965915G>A	uc002pnt.2	+	8	1117	c.1001G>A	c.(1000-1002)CGA>CAA	p.R334Q	ALDH16A1_uc010yar.1_Missense_Mutation_p.R283Q|ALDH16A1_uc010yas.1_Missense_Mutation_p.R169Q|ALDH16A1_uc010yat.1_Missense_Mutation_p.R171Q	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	334							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CGGAGTGGCCGAGGGCTGGAT	0.672													0	0	0	1	0	31	65										A	49965915	G	A	49965915	3	1	18	1	0	0	0	0	1	0	0	0	488	1058	37	1	1031	1	ALDH16A1	19	49965915	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	885	49965915	9163068	496	5070										
ZNF615	284370	broad.mit.edu	37	chr19	52505446	52505447	+	Frame_Shift_Ins	INS	-	-	C													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gtagttctccaacatcacgtINScccggtacaggtccttctga							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:52505446_52505447insC	uc002pye.1	-	4	395_396	c.103_104insG	c.(103-105)GACfs	p.D35fs	ZNF615_uc002pyf.1_Frame_Shift_Ins_p.D35fs|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Frame_Shift_Ins_p.D35fs|ZNF615_uc010epi.1_Frame_Shift_Ins_p.D31fs|ZNF615_uc010ydg.1_Frame_Shift_Ins_p.D40fs	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CAACATCACGTCCCGGTACAGG	0.564																		204	180	---	---								C	52505447	-	C	52505446	7	5	18	1	0	1	1	0	0	0	0	0	18037	1667	58	0	2103	0	ZNF615	19	52505446	Frame_Shift_Ins	INS	-	TCGA-BT-A3PH-01A-11D-A21Z-08	2539531	52505446	6623537	497	5071										
ZNF616	90317	broad.mit.edu	37	chr19	52618746	52618746	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agacgtgaacattgactgaaGaccttgccacattctttgca	8	10	1	5			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:52618746G>A	uc002pym.2	-	4	1954	c.1671C>T	c.(1669-1671)GTC>GTT	p.V557V	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	557	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		ATTGACTGAAGACCTTGCCAC	0.438													0	0	0	1	0	58	34										A	52618746	G	A	52618746	2	1	18	1	0	0	0	0	0	0	0	1	18038	929	33	1		1	ZNF616	19	52618746	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	113300	52618746	6510237	498	5072										
ZNF321	399669	broad.mit.edu	37	chr19	53432634	53432634	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tattgccttgcgctgtggatGagaactccttcatcatgcat	9	10	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:53432634G>A	uc010eqj.2	-	4	346	c.176C>T	c.(175-177)TCA>TTA	p.S59L	ZNF321_uc002qaj.1_Missense_Mutation_p.S6L|ZNF321_uc002qak.1_Missense_Mutation_p.S59L	NM_203307	NP_976052			zinc finger protein 321												0				GBM - Glioblastoma multiforme(134;0.0305)		CGCTGTGGATGAGAACTCCTT	0.353													0	0	0	1	0	104	88										A	53432634	G	A	53432634	3	1	18	1	0	0	0	0	1	0	0	0	17837	1294	45	1	481	1	ZNF321	19	53432634	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	813888	53432634	5696349	499	5073										
TNNT1	7138	broad.mit.edu	37	chr19	55645272	55645272	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cacaacttctgggcgtggctGatgcggttgtacagcacgtt	13	10	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:55645272G>A	uc002qjb.3	-	13	863	c.774C>T	c.(772-774)ATC>ATT	p.I258I	TNNT1_uc002qiz.3_Silent_p.I172I|TNNT1_uc002qja.3_Silent_p.I172I|TNNT1_uc002qjc.3_Silent_p.I242I|TNNT1_uc002qje.3_Silent_p.I231I|TNNT1_uc002qjd.3_Silent_p.I231I	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	258					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		GGGCGTGGCTGATGCGGTTGT	0.627													0	0	0	1	0	50	30										A	55645272	G	A	55645272	2	1	18	1	0	0	0	0	0	0	0	1	16327	1280	45	1		1	TNNT1	19	55645272	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2212638	55645272	3483711	500	5074										
C19orf51	352909	broad.mit.edu	37	chr19	55672758	55672758	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcctgtgtcccgccagcgtCggaactcctgggggtgaatg	15	13	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:55672758C>A	uc002qji.1	-	7	726	c.692G>T	c.(691-693)CGA>CTA	p.R231L	C19orf51_uc002qjh.1_Missense_Mutation_p.R46L|C19orf51_uc002qjj.1_Missense_Mutation_p.R278L|C19orf51_uc002qjk.1_Missense_Mutation_p.R177L|C19orf51_uc002qjl.1_Missense_Mutation_p.R299L			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	231											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CCGCCAGCGTCGGAACTCCTG	0.587													1	0	0.00307968	1	0.00309483	6	16										A	55672758	C	A	55672758	3	1	18	1	0	0	0	0	1	0	0	0	1933	884	31	3	957	3	C19orf51	19	55672758	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	27486	55672758	3456225	501	5075										
NLRP8	126205	broad.mit.edu	37	chr19	56466732	56466732	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tatatttctagcttgtttccCaccagagctgagaacttttc	6	10	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:56466732C>T	uc002qmh.2	+	3	1379	c.1308C>T	c.(1306-1308)CCC>CCT	p.P436P	NLRP8_uc010etg.2_Silent_p.P436P	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	436	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCTTGTTTCCCACCAGAGCTG	0.488													0	0	0	1	0	65	42										T	56466732	C	T	56466732	2	4	18	1	0	0	0	0	0	0	0	1	10483	581	21	2		2	NLRP8	19	56466732	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	793974	56466732	2662251	502	5076										
ZNF582	147948	broad.mit.edu	37	chr19	56895395	56895395	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tctgaggttgaacggtagttGaatcatgactcaaggtcttc	11	7	4	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:56895395G>C	uc002qmz.1	-	5	1550	c.1391C>G	c.(1390-1392)TCA>TGA	p.S464*	ZNF582_uc002qmy.2_Nonsense_Mutation_p.S495*	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		AACGGTAGTTGAATCATGACT	0.363													0	0	0	1	0	23	108										C	56895395	G	C	56895395	4	2	18	1	0	0	0	0	0	1	0	0	18011	1294	45	1	166	1	ZNF582	19	56895395	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	428663	56895395	2233588	503	5077										
ZNF470	388566	broad.mit.edu	37	chr19	57088680	57088680	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aatgtgggaaagccttcagcCagaatgctcatcttgttcaa	9	9	4	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:57088680C>G	uc002qnl.3	+	6	1559	c.883C>G	c.(883-885)CAG>GAG	p.Q295E	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	295	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGCCTTCAGCCAGAATGCTCA	0.448													0	0	0	1	0	58	50										G	57088680	C	G	57088680	3	3	18	1	0	0	0	0	1	0	0	0	17926	595	21	4	897	4	ZNF470	19	57088680	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	193285	57088680	2040303	504	5078										
MZF1	7593	broad.mit.edu	37	chr19	59073565	59073565	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agatgctgcgtgagcgtgggCcgctggcggaaggccttgcc	18	11	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr19:59073565C>T	uc002qto.2	-	6	2640	c.2079G>A	c.(2077-2079)CGG>CGA	p.R693R	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Silent_p.R693R	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	693	C2H2-type 12.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		TGAGCGTGGGCCGCTGGCGGA	0.667													0	0	0	1	0	7	26										T	59073565	C	T	59073565	2	4	18	1	0	0	0	0	0	0	0	1	10108	726	26	2		2	MZF1	19	59073565	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1984885	59073565	55418	505	5079										
CSRP2BP	57325	broad.mit.edu	37	chr20	18123337	18123337	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atccacctgagtagtctgatCagtcggcatgatgacgaagc	11	10	2	4			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:18123337C>G	uc002wqj.2	+	2	655	c.33C>G	c.(31-33)ATC>ATG	p.I11M	CSRP2BP_uc002wqk.2_5'Flank	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	11					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						GTAGTCTGATCAGTCGGCATG	0.527													0	0	0	1	0	22	25										G	18123337	C	G	18123337	3	3	18	1	0	0	0	0	1	0	0	0	3968	816	29	1	35	1	CSRP2BP	20	18123337	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		18123337	44902183	506	5080										
ASXL1	171023	broad.mit.edu	37	chr20	30956842	30956842	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acttcccctctcgcatgcctCaatgctatgctacattccaa	4	16	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:30956842C>G	uc002wxs.2	+	3	594	c.168C>G	c.(166-168)CTC>CTG	p.L56L	ASXL1_uc002wxr.1_RNA|ASXL1_uc002wxt.2_RNA|ASXL1_uc010geb.2_5'UTR	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	56					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TCGCATGCCTCAATGCTATGC	0.443			F|N|Mis		MDS|CMML								0	0	0	1	0	59	73										G	30956842	C	G	30956842	2	3	18	1	0	0	0	0	0	0	0	1	1066	813	29	1		1	ASXL1	20	30956842	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	12833505	30956842	32068678	507	5081										
EDEM2	55741	broad.mit.edu	37	chr20	33703305	33703305	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagggctgactggggcagctGagaagtgggaccttctgttt	16	7	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:33703305G>A	uc002xbo.2	-	11	1768	c.1668C>T	c.(1666-1668)CTC>CTT	p.L556L	EDEM2_uc010zus.1_Silent_p.L335L|EDEM2_uc002xbq.2_Silent_p.L519L|EDEM2_uc010zut.1_Silent_p.L515L|EDEM2_uc002xbp.2_Silent_p.L404L|EDEM2_uc002xbn.2_Silent_p.L404L|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Silent_p.L280L	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	556					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TGGGGCAGCTGAGAAGTGGGA	0.488													0	0	0	1	0	131	193										A	33703305	G	A	33703305	2	1	18	1	0	0	0	0	0	0	0	1	4912	1277	45	1		1	EDEM2	20	33703305	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	2746463	33703305	29322215	508	5082										
CEP250	11190	broad.mit.edu	37	chr20	34091303	34091303	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggccgggagctgaccactcaGaggcagctgatgcaggaacg	16	11	1	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:34091303G>C	uc002xcm.2	+	31	5777	c.5106G>C	c.(5104-5106)CAG>CAC	p.Q1702H	CEP250_uc010zve.1_Missense_Mutation_p.Q1070H	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1702	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TGACCACTCAGAGGCAGCTGA	0.587													0	0	0	1	0	66	93										C	34091303	G	C	34091303	3	2	18	1	0	0	0	0	1	0	0	0	3252	933	33	1	5212	1	CEP250	20	34091303	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	387998	34091303	28934217	509	5083										
SLA2	84174	broad.mit.edu	37	chr20	35243657	35243657	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtccaccagggcctggagtGaggggaaggtgaggcgcggt	21	8	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:35243657G>C	uc002xfv.2	-	6	865	c.503C>G	c.(502-504)TCA>TGA	p.S168*	SLA2_uc002xfu.2_Nonsense_Mutation_p.S168*	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2 isoform a	168	SH2.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GGCCTGGAGTGAGGGGAAGGT	0.617													0	0	0	1	0	32	71										C	35243657	G	C	35243657	4	2	18	1	0	0	0	0	0	1	0	0	14364	1294	45	1	294	1	SLA2	20	35243657	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1152354	35243657	27781863	510	5084										
BPI	671	broad.mit.edu	37	chr20	36948673	36948673	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gagaccctggatgtacagatGaaggtgaggctgacactgag	15	7	0	6			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:36948673G>T	uc002xib.2	+	7	827	c.765G>T	c.(763-765)ATG>ATT	p.M255I		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	255					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				ATGTACAGATGAAGGTGAGGC	0.468													1	0	3.86903e-22	1	4.05421e-22	30	37										T	36948673	G	T	36948673	3	4	18	1	0	0	0	0	1	0	0	0	1490	1290	45	3	791	3	BPI	20	36948673	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	1705016	36948673	26076847	511	5085										
SLC32A1	140679	broad.mit.edu	37	chr20	37356882	37356882	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggtggccaaggcgctgttgtCctatcctctgccattctttg	11	12	2	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:37356882C>A	uc002xjc.2	+	2	1441	c.1178C>A	c.(1177-1179)TCC>TAC	p.S393Y		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	393	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCGCTGTTGTCCTATCCTCTG	0.627													1	0	2.44723e-14	1	2.52127e-14	21	49										A	37356882	C	A	37356882	3	1	18	1	0	0	0	0	1	0	0	0	14565	855	30	3	1184	3	SLC32A1	20	37356882	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	408209	37356882	25668638	512	5086										
SERINC3	10955	broad.mit.edu	37	chr20	43129838	43129838	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agcccgccgaggctgtccatCttcttcatcactggcaccac	8	17	4	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:43129838C>G	uc002xme.2	-	9	1293	c.1159G>C	c.(1159-1161)GAT>CAT	p.D387H	SERINC3_uc002xmf.1_Missense_Mutation_p.D387H|SERINC3_uc010ggs.1_Missense_Mutation_p.D380H|SERINC3_uc010zwp.1_Missense_Mutation_p.D332H	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	387	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GGCTGTCCATCTTCTTCATCA	0.517													0	0	0	1	0	70	101										G	43129838	C	G	43129838	3	3	18	1	0	0	0	0	1	0	0	0	14081	913	32	1	270	1	SERINC3	20	43129838	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	5772956	43129838	19895682	513	5087										
PCIF1	63935	broad.mit.edu	37	chr20	44571881	44571881	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	atcatgaacgacattcctatCaggtacagctccacagctgg	8	12	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:44571881C>T	uc002xqs.2	+	8	1133	c.819C>T	c.(817-819)ATC>ATT	p.I273I	PCIF1_uc002xqt.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	273						nucleus				skin(1)	1						ACATTCCTATCAGGTACAGCT	0.517													0	0	0	1	0	57	85										T	44571881	C	T	44571881	2	4	18	1	0	0	0	0	0	0	0	1	11580	816	29	1		1	PCIF1	20	44571881	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1442043	44571881	18453639	514	5088										
PRPF6	24148	broad.mit.edu	37	chr20	62659061	62659061	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccattttggaaaagtctcgtCtgaagaacccaaagaaccct	7	11	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr20:62659061C>T	uc002yho.2	+	17	2479	c.2311C>T	c.(2311-2313)CTG>TTG	p.L771L	PRPF6_uc002yhp.2_Silent_p.L731L	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	771					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					AAAGTCTCGTCTGAAGAACCC	0.612													0	0	0	1	0	96	88										T	62659061	C	T	62659061	2	4	18	1	0	0	0	0	0	0	0	1	12574	912	32	1		1	PRPF6	20	62659061	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	18087180	62659061	366459	515	5089										
PRDM15	63977	broad.mit.edu	37	chr21	43222884	43222884	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaactgacctgctgaatgctCtgtactgcggaattggtctc	10	10	2	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr21:43222884C>G	uc002yzq.1	-	30	4140	c.4029G>C	c.(4027-4029)CAG>CAC	p.Q1343H	PRDM15_uc002yzo.2_Missense_Mutation_p.Q1014H|PRDM15_uc002yzp.2_Missense_Mutation_p.Q1034H|PRDM15_uc002yzr.1_Missense_Mutation_p.Q1034H	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCTGAATGCTCTGTACTGCGG	0.527													0	0	0	1	0	116	145										G	43222884	C	G	43222884	3	3	18	1	0	0	0	0	1	0	0	0	12456	912	32	1	502	1	PRDM15	21	43222884	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		43222884	4907011	516	5090										
KRTAP10-10	353333	broad.mit.edu	37	chr21	46057969	46057969	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgtcccctcctgcggtgcctCtgcctcctcctgccagccca	8	22	1	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr21:46057969C>T	uc002zfq.2	+	1	697	c.635C>T	c.(634-636)TCT>TTT	p.S212F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	212	15 X 5 AA repeats of C-C-X(3).					keratin filament					0						TGCGGTGCCTCTGCCTCCTCC	0.697													0	0	0	1	0	78	85										T	46057969	C	T	46057969	3	4	18	1	0	0	0	0	1	0	0	0	8506	913	32	1	637	1	KRTAP10-10	21	46057969	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	2835085	46057969	2071926	517	5091										
UFD1L	7353	broad.mit.edu	37	chr22	19459219	19459219	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	gccccactcacccagtgtggGaggtagcagatgccctcatc	11	15	2	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:19459219G>C	uc002zpm.2	-	4	412	c.282C>G	c.(280-282)CTC>CTG	p.L94L	UFD1L_uc002zpo.2_Silent_p.L94L|UFD1L_uc011agy.1_Silent_p.L94L|UFD1L_uc002zpp.2_Silent_p.L47L|UFD1L_uc010grq.2_Silent_p.L47L	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	94					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					CCCAGTGTGGGAGGTAGCAGA	0.572													0	0	0	1	0	26	46										C	19459219	G	C	19459219	2	2	18	1	0	0	0	0	0	0	0	1	16932	1161	41	1		1	UFD1L	22	19459219	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08		19459219	31845347	518	5092										
DERL3	91319	broad.mit.edu	37	chr22	24179997	24179997	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acgtacaccagcatggccatGagggcctggcccaggaagaa	13	12	0	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:24179997G>A	uc002zyh.2	-	5	397	c.372C>T	c.(370-372)CTC>CTT	p.L124L	DERL3_uc002zyk.3_Silent_p.L124L|DERL3_uc002zyi.2_Silent_p.L124L|DERL3_uc002zyj.2_Intron	NM_001002862	NP_001002862	Q96Q80	DERL3_HUMAN	derlin 3 isoform 2	124	Lumenal (Potential).				endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	integral to endoplasmic reticulum membrane	protein binding			ovary(1)	1						GCATGGCCATGAGGGCCTGGC	0.677													0	0	0	1	0	33	51										A	24179997	G	A	24179997	2	1	18	1	0	0	0	0	0	0	0	1	4448	1277	45	1		1	DERL3	22	24179997	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	4720778	24179997	27124569	519	5093										
CYTSA	23384	broad.mit.edu	37	chr22	24717865	24717865	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ccctgataaccagagcgatgGaggaggaactctgacttctt	11	10	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:24717865G>C	uc002zzw.2	+	5	1224	c.917G>C	c.(916-918)GGA>GCA	p.G306A	CYTSA_uc002zzv.3_Missense_Mutation_p.G306A|CYTSA_uc011ajq.1_Missense_Mutation_p.G306A	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	306					cell cycle|cell division						0						CAGAGCGATGGAGGAGGAACT	0.493													0	0	0	1	0	65	123										C	24717865	G	C	24717865	3	2	18	1	0	0	0	0	1	0	0	0	4209	1174	41	1	927	1	CYTSA	22	24717865	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	537868	24717865	26586701	520	5094										
RNF215	200312	broad.mit.edu	37	chr22	30780387	30780387	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ctgccatcctccatagccatCcttggagaggccacaggtgg	11	14	0	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:30780387C>G	uc003ahp.2	-	5	685	c.685G>C	c.(685-687)GAT>CAT	p.D229H	RNF215_uc011akw.1_Missense_Mutation_p.D134H	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	229	Extracellular (Potential).					integral to membrane	zinc ion binding			central_nervous_system(1)	1						CCATAGCCATCCTTGGAGAGG	0.602													0	0	0	1	0	52	79										G	30780387	C	G	30780387	3	3	18	1	0	0	0	0	1	0	0	0	13479	855	30	1	468	1	RNF215	22	30780387	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	6062522	30780387	20524179	521	5095										
SEC14L2	23541	broad.mit.edu	37	chr22	30803141	30803141	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcattagctggcagcctccaGaggtgagcacaaattatccc	9	12	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:30803141G>C	uc003ahr.2	+	4	405	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	SEC14L2_uc003ahq.2_Missense_Mutation_p.E78Q|SEC14L2_uc011akx.1_Missense_Mutation_p.E24Q|SEC14L2_uc003ahs.2_Intron|SEC14L2_uc011aky.1_Intron|SEC14L2_uc003aht.2_5'Flank|SEC14L2_uc003ahu.3_5'Flank|SEC14L2_uc010gvv.2_5'Flank|SEC14L2_uc010gvw.1_5'Flank|MTP18_uc010gvx.1_5'Flank|MTP18_uc003ahv.1_5'Flank|MTP18_uc010gvy.1_5'Flank	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	78	CRAL-TRIO.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	GCAGCCTCCAGAGGTGAGCAC	0.473													0	0	0	1	0	30	29										C	30803141	G	C	30803141	3	2	18	1	0	0	0	0	1	0	0	0	13982	943	33	1	246	1	SEC14L2	22	30803141	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	22754	30803141	20501425	522	5096										
DEPDC5	9681	broad.mit.edu	37	chr22	32269279	32269279	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagctccttgacctcatcctCtaccctgacagagatcctgg	7	15	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:32269279C>G	uc003als.2	+	34	3573	c.3431C>G	c.(3430-3432)TCT>TGT	p.S1144C	DEPDC5_uc011als.1_Missense_Mutation_p.S1075C|DEPDC5_uc011alu.1_Missense_Mutation_p.S1175C|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.S1166C|DEPDC5_uc003alu.2_Missense_Mutation_p.S593C|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_3'UTR|DEPDC5_uc003alw.2_Missense_Mutation_p.S442C|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_Missense_Mutation_p.S170C|DEPDC5_uc011aly.1_5'UTR	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1144					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ACCTCATCCTCTACCCTGACA	0.547													0	0	0	1	0	67	117										G	32269279	C	G	32269279	3	3	18	1	0	0	0	0	1	0	0	0	4442	913	32	1	3649	1	DEPDC5	22	32269279	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1466138	32269279	19035287	523	5097										
EP300	2033	broad.mit.edu	37	chr22	41489048	41489048	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaccggggccgccttcagccAagcggcctaaactctcatct	9	16	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:41489048A>C	uc003azl.3	+	1	435	c.40A>C	c.(40-42)AAG>CAG	p.K14Q		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	14	Interaction with ALX1.|Nuclear localization signal (Potential).				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GCCTTCAGCCAAGCGGCCTAA	0.547			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	1	0	128	151										C	41489048	A	C	41489048	3	2	18	1	0	0	0	0	1	0	0	0	5148	131	5	5	42	5	EP300	22	41489048	Missense_Mutation	SNP	A	TCGA-BT-A3PH-01A-11D-A21Z-08	9219769	41489048	9815518	524	5098										
TCF20	6942	broad.mit.edu	37	chr22	42609617	42609617	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ttgagtctggggggttcattCtgagcaccttgtgccggtga	15	8	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:42609617C>T	uc003bcj.1	-	1	1829	c.1695G>A	c.(1693-1695)CAG>CAA	p.Q565Q	TCF20_uc003bck.1_Silent_p.Q565Q|TCF20_uc003bnt.2_Silent_p.Q565Q	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GGGGTTCATTCTGAGCACCTT	0.582													0	0	0	1	0	41	54										T	42609617	C	T	42609617	2	4	18	1	0	0	0	0	0	0	0	1	15687	912	32	1		1	TCF20	22	42609617	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	1120569	42609617	8694949	525	5099										
TUBGCP6	85378	broad.mit.edu	37	chr22	50682166	50682166	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	accttaatagccagcccagaGaggtccgcattgtctggcac	10	13	1	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:50682166G>C	uc003bkb.1	-	1	1235	c.723C>G	c.(721-723)CTC>CTG	p.L241L	TUBGCP6_uc010har.1_Silent_p.L241L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Silent_p.L241L	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	241					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCAGCCCAGAGAGGTCCGCAT	0.522													0	0	0	1	0	36	47										C	50682166	G	C	50682166	2	2	18	1	0	0	0	0	0	0	0	1	16767	929	33	1		1	TUBGCP6	22	50682166	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	8072549	50682166	622400	526	5100										
TUBGCP6	85378	broad.mit.edu	37	chr22	50682726	50682726	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	catgtcaggctgcagctgttGagtctcatcttgaaaaagat	10	8	3	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chr22:50682726G>A	uc003bkb.1	-	1	675	c.163C>T	c.(163-165)CAA>TAA	p.Q55*	TUBGCP6_uc010har.1_Nonsense_Mutation_p.Q55*|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Nonsense_Mutation_p.Q55*	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	55					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCAGCTGTTGAGTCTCATCT	0.532													0	0	0	1	0	61	97										A	50682726	G	A	50682726	4	1	18	1	0	0	0	0	0	1	0	0	16767	1299	45	1	5396	1	TUBGCP6	22	50682726	Nonsense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	560	50682726	621840	527	5101										
OFD1	8481	broad.mit.edu	37	chrX	13757019	13757019	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aaatcaaccctacttccagtCtctacaaatcactggtaaga	4	12	3	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:13757019C>G	uc004cvp.3	+	4	726	c.367C>G	c.(367-369)CTC>GTC	p.L123V	OFD1_uc004cvr.3_5'UTR|OFD1_uc011mil.1_5'UTR|OFD1_uc004cvq.3_5'UTR|OFD1_uc010nen.2_Missense_Mutation_p.L122V|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.L122V|OFD1_uc004cvv.3_Missense_Mutation_p.L122V	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	123					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						TACTTCCAGTCTCTACAAATC	0.284													0	0	0	1	0	63	5										G	13757019	C	G	13757019	3	3	18	1	0	0	0	0	1	0	0	0	10838	913	32	1	381	1	OFD1	23	13757019	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08		13757019	141513541	528	5102										
CYBB	1536	broad.mit.edu	37	chrX	37664367	37664367	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	acacccttcgcatccattctCaagtcagtctggtacaaata	5	13	3	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:37664367C>T	uc004ddr.2	+	10	1321	c.1260C>T	c.(1258-1260)CTC>CTT	p.L420L	CYBB_uc011mkf.1_Silent_p.L388L|CYBB_uc011mkg.1_Silent_p.L153L	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	420	Cytoplasmic (Potential).		L -> P (in XCGD).		electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CATCCATTCTCAAGTCAGTCT	0.473													0	0	0	1	0	39	6										T	37664367	C	T	37664367	2	4	18	1	0	0	0	0	0	0	0	1	4133	813	29	1		1	CYBB	23	37664367	Silent	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	23907348	37664367	117606193	529	5103										
KDM6A	7403	broad.mit.edu	37	chrX	44918318	44918318	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	ggcagtctattgataaatcaGaagcaagtgcagatacatgg	11	6	2	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:44918318G>C	uc004dge.3	+	11	1318	c.943G>C	c.(943-945)GAA>CAA	p.E315Q	KDM6A_uc010nhk.2_Missense_Mutation_p.E315Q|KDM6A_uc011mkz.1_Missense_Mutation_p.E315Q|KDM6A_uc011mla.1_Missense_Mutation_p.E315Q|KDM6A_uc011mlb.1_Missense_Mutation_p.E315Q|KDM6A_uc011mlc.1_Missense_Mutation_p.E64Q|KDM6A_uc011mld.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	315	TPR 6.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGATAAATCAGAAGCAAGTGC	0.328			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	1	0	42	7										C	44918318	G	C	44918318	3	2	18	1	0	0	0	0	1	0	0	0	8137	943	33	1	985	1	KDM6A	23	44918318	Missense_Mutation	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	7253951	44918318	110352242	530	5104										
KDM6A	7403	broad.mit.edu	37	chrX	44941858	44941858	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	aagtcatcataaagaccactCagatagtgaatctacatcgt	6	9	4	3			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:44941858C>G	uc004dge.3	+	21	3557	c.3182C>G	c.(3181-3183)TCA>TGA	p.S1061*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.S1113*|KDM6A_uc011mla.1_Nonsense_Mutation_p.S1016*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.S1068*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.S765*|KDM6A_uc011mld.1_Nonsense_Mutation_p.S700*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1061					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAGACCACTCAGATAGTGAA	0.313			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	1	0	39	4										G	44941858	C	G	44941858	4	3	18	1	0	0	0	0	0	1	0	0	8137	838	29	1	3264	1	KDM6A	23	44941858	Nonsense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	23540	44941858	110328702	531	5105										
CXorf36	79742	broad.mit.edu	37	chrX	45010958	45010958	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	caaatctggagtcacacgttCtcaggggcctcaagatgtct	10	11	5	1			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:45010958C>G	uc004dgg.2	-	5	1316	c.1241G>C	c.(1240-1242)AGA>ACA	p.R414T		NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	414						extracellular region				lung(1)	1						GTCACACGTTCTCAGGGGCCT	0.537													0	0	0	1	0	96	11										G	45010958	C	G	45010958	3	3	18	1	0	0	0	0	1	0	0	0	4106	913	32	1	64	1	CXorf36	23	45010958	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	69100	45010958	110259602	532	5106										
RGAG4	340526	broad.mit.edu	37	chrX	71350506	71350506	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	agaatcagctcatccaggtcGgccatttctgttgaccataa	8	11	3	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:71350506G>T	uc010nlh.1	-	1	1246	c.885C>A	c.(883-885)GCC>GCA	p.A295A	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	295										ovary(2)|skin(1)	3	Renal(35;0.156)					CATCCAGGTCGGCCATTTCTG	0.493													1	0	6.60522e-78	1	7.10351e-78	127	7										T	71350506	G	T	71350506	2	4	18	1	0	0	0	0	0	0	0	1	13275	1103	39	4		4	RGAG4	23	71350506	Silent	SNP	G	TCGA-BT-A3PH-01A-11D-A21Z-08	26339548	71350506	83920054	533	5107										
IRS4	8471	broad.mit.edu	37	chrX	107977802	107977803	+	Frame_Shift_Ins	INS	-	-	C													0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tcccacttcctgagcctttgINSccccccccagagttcttgcc							TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:107977802_107977803insC	uc004eoc.2	-	1	1805_1806	c.1772_1773insG	c.(1771-1773)GGCfs	p.G591fs		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	591						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTGAGCCTTTGCCCCCCCCAGA	0.545																		8	409	---	---								C	107977803	-	C	107977802	7	5	18	1	0	1	1	0	0	0	0	0	7842	1306	46	0	2004	0	IRS4	23	107977802	Frame_Shift_Ins	INS	-	TCGA-BT-A3PH-01A-11D-A21Z-08	36627296	107977802	47292758	534	5108										
DCAF12L2	340578	broad.mit.edu	37	chrX	125299171	125299171	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	tggcctccacatccctcggaCggatgtgggcatatactggg	13	12	0	0			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:125299171C>T	uc004euk.1	-	1	764	c.737G>A	c.(736-738)CGT>CAT	p.R246H		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	246										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ATCCCTCGGACGGATGTGGGC	0.647													0	0	0	1	0	29	0										T	125299171	C	T	125299171	3	4	18	1	0	0	0	0	1	0	0	0	4265	536	19	2	658	2	DCAF12L2	23	125299171	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	17321369	125299171	29971389	535	5109										
GPR101	83550	broad.mit.edu	37	chrX	136113144	136113144	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.597378277153558	319	6.46836842577713e-128	4.22948919890639	4.77668322670081	3.63233397726988	1.33901146169682e-05	0.000108794681262867	244	cgcacttccaagctgtgtctCttgacattgtacagcagagc	9	12	1	2			TCGA-BT-A3PH-01A-11D-A21Z-08	TCGA-BT-A3PH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cda1a403-16b6-487c-a82a-c377d1d0f89d	f7ffcce9-2a24-4abe-8f8c-b9ba6a770803	g.chrX:136113144C>G	uc011mwh.1	-	1	690	c.690G>C	c.(688-690)AAG>AAC	p.K230N		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	230	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGCTGTGTCTCTTGACATTGT	0.522													0	0	0	1	0	114	11										G	136113144	C	G	136113144	3	3	18	1	0	0	0	0	1	0	0	0	6622	912	32	1	839	1	GPR101	23	136113144	Missense_Mutation	SNP	C	TCGA-BT-A3PH-01A-11D-A21Z-08	10813973	136113144	19157416	536	5110										
AURKAIP1	54998	broad.mit.edu	37	chr1	1309762	1309762	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgggccggccggcgatgtgCtgtaaaggggcccgcagacc	17	13	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:1309762C>G	uc001afb.1	-	2	226	c.116G>C	c.(115-117)AGC>ACC	p.S39T	AURKAIP1_uc001afc.2_Missense_Mutation_p.S39T|AURKAIP1_uc001afd.2_Missense_Mutation_p.S39T|AURKAIP1_uc009vkb.1_Missense_Mutation_p.S39T	NM_017900	NP_060370	Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	39					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGGCGATGTGCTGTAAAGGGG	0.706													0	0	0	0.00308	0	7	9										G	1309762	C	G	1309762	3	3	19	1	0	0	0	0	1	0	0	0	1222	797	28	4	491	4	AURKAIP1	1	1309762	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		1309762	247940859	1	5111										
PER3	8863	broad.mit.edu	37	chr1	7887376	7887376	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagcccgaccttcccacctgCcgccatggtgcccagccagg	11	19	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:7887376C>T	uc001aoo.2	+	17	2538	c.2363C>T	c.(2362-2364)GCC>GTC	p.A788V	PER3_uc009vmg.1_Missense_Mutation_p.A796V|PER3_uc009vmh.1_Missense_Mutation_p.A789V|PER3_uc001aop.2_Missense_Mutation_p.A796V|PER3_uc010nzw.1_Missense_Mutation_p.A477V	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	788	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCCACCTGCCGCCATGGTG	0.701													0	0	0	0.01441	0	46	85										T	7887376	C	T	7887376	3	4	19	1	0	0	0	0	1	0	0	0	11731	739	26	2	2429	2	PER3	1	7887376	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6577614	7887376	241363245	2	5112										
SLC45A1	50651	broad.mit.edu	37	chr1	8386045	8386045	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccagccacgcctacatgatgGacgtgtgcagccccgcagac	11	16	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8386045G>A	uc001apb.2	+	3	658	c.658G>A	c.(658-660)GAC>AAC	p.D220N		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	220					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTACATGATGGACGTGTGCAG	0.662													0	0	0	0.01441	0	65	167										A	8386045	G	A	8386045	3	1	19	1	0	0	0	0	1	0	0	0	14640	1174	41	1	668	1	SLC45A1	1	8386045	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	498669	8386045	240864576	3	5113										
SLC45A1	50651	broad.mit.edu	37	chr1	8390858	8390858	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggctgtgacggggacattctGagggtgggctccttggacac	17	9	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8390858G>A	uc001apb.2	+	4	1305	c.1305G>A	c.(1303-1305)CTG>CTA	p.L435L	SLC45A1_uc001apc.2_Silent_p.L133L	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	435					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACATTCTGAGGGTGGGCT	0.662													0	0	0	0.013726	0	28	83										A	8390858	G	A	8390858	2	1	19	1	0	0	0	0	0	0	0	1	14640	1277	45	1		1	SLC45A1	1	8390858	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4813	8390858	240859763	4	5114										
SLC45A1	50651	broad.mit.edu	37	chr1	8399581	8399581	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagaagctggaggagttcctCagcgtccgcaccctctactt	11	13	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8399581C>T	uc001apb.2	+	7	1803	c.1803C>T	c.(1801-1803)CTC>CTT	p.L601L	SLC45A1_uc001apc.2_Silent_p.L299L	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	601	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGTTCCTCAGCGTCCGCA	0.637													0	0	0	0.011902	0	40	85										T	8399581	C	T	8399581	2	4	19	1	0	0	0	0	0	0	0	1	14640	813	29	1		1	SLC45A1	1	8399581	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8723	8399581	240851040	5	5115										
FBXO2	26232	broad.mit.edu	37	chr1	11708769	11708769	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctcagggttctacccacacGctgctgttggtcacccgggc	12	15	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:11708769G>A	uc001asj.2	-	6	1215	c.873C>T	c.(871-873)AGC>AGT	p.S291S	FBXO2_uc009vna.2_Silent_p.S294S	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	291	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CTACCCACACGCTGCTGTTGG	0.657													0	0	0	0.01441	0	40	69										A	11708769	G	A	11708769	2	1	19	1	0	0	0	0	0	0	0	1	5732	1078	38	2		2	FBXO2	1	11708769	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3309188	11708769	237541852	6	5116										
PADI1	29943	broad.mit.edu	37	chr1	17552410	17552410	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacctcacccacagctggctGatgtcgctggctggtgagtg	14	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:17552410G>A	uc001bah.1	+	5	605	c.513G>A	c.(511-513)CTG>CTA	p.L171L		NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	171					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	ACAGCTGGCTGATGTCGCTGG	0.612													0	0	0	0.01441	0	111	223										A	17552410	G	A	17552410	2	1	19	1	0	0	0	0	0	0	0	1	11377	1277	45	1		1	PADI1	1	17552410	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5843641	17552410	231698211	7	5117										
ARID1A	8289	broad.mit.edu	37	chr1	27057835	27057835	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caccacagctccagtcctctCagcctccatactcccagcag	5	20	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:27057835C>T	uc001bmv.1	+	3	1916	c.1543C>T	c.(1543-1545)CAG>TAG	p.Q515*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q515*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q515*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q132*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	515					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAGTCCTCTCAGCCTCCATA	0.632			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	237	398										T	27057835	C	T	27057835	4	4	19	1	0	0	0	0	0	1	0	0	913	827	29	1	1553	1	ARID1A	1	27057835	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9505425	27057835	222192786	8	5118										
TRNAU1AP	54952	broad.mit.edu	37	chr1	28898397	28898397	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agacatatgaagaagttggaGatgatgcattggaaggtaag	14	2	0	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:28898397G>C	uc001bqi.2	+	8	806	c.712G>C	c.(712-714)GAT>CAT	p.D238H	TRNAU1AP_uc001bqh.2_Missense_Mutation_p.D128H|TRNAU1AP_uc010ofw.1_Missense_Mutation_p.D128H	NM_017846	NP_060316	Q9NX07	TSAP1_HUMAN	tRNA selenocysteine associated protein 1	238					selenocysteine incorporation	cytoplasm|nucleus	nucleotide binding|RNA binding				0						AGAAGTTGGAGATGATGCATT	0.333													0	0	0	0.01441	0	40	88										C	28898397	G	C	28898397	3	2	19	1	0	0	0	0	1	0	0	0	16569	942	33	1	742	1	TRNAU1AP	1	28898397	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1840562	28898397	220352224	9	5119										
BSDC1	55108	broad.mit.edu	37	chr1	32849566	32849566	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagtcagataaccctttcttCatcttctctgttgctcctga	5	12	5	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:32849566C>T	uc001bvh.3	-	4	269	c.222G>A	c.(220-222)ATG>ATA	p.M74I	BSDC1_uc010ohg.1_Missense_Mutation_p.M91I|BSDC1_uc010ohh.1_Intron|BSDC1_uc010ohi.1_Intron|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Intron|BSDC1_uc001bvi.2_Missense_Mutation_p.M91I	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	74							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCCTTTCTTCATCTTCTCTG	0.547													0	0	0	0.009535	0	27	95										T	32849566	C	T	32849566	3	4	19	1	0	0	0	0	1	0	0	0	1528	826	29	1	1102	1	BSDC1	1	32849566	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3951169	32849566	216401055	10	5120										
EIF2C4	192670	broad.mit.edu	37	chr1	36301442	36301442	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attatttttgtagcggaggtGaaacgtgttggagataccct	12	5	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:36301442G>A	uc001bzj.1	+	13	1762	c.1572G>A	c.(1570-1572)GTG>GTA	p.V524V		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	524	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TAGCGGAGGTGAAACGTGTTG	0.368													0	0	0	0.00308	0	8	22										A	36301442	G	A	36301442	2	1	19	1	0	0	0	0	0	0	0	1	5008	1277	45	1		1	EIF2C4	1	36301442	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3451876	36301442	212949179	11	5121										
RRAGC	64121	broad.mit.edu	37	chr1	39325198	39325200	+	In_Frame_Del	DEL	CCG	CCG	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccctgccccaacccctccgcCcgccgccgccgcctcctctt					rs113599946		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:39325198_39325200delCCG	uc001ccq.2	-	1	141_143	c.119_121delCGG	c.(118-123)GCGGGC>GGC	p.A40del	RRAGC_uc010oim.1_In_Frame_Del_p.A40del|RRAGC_uc001ccr.2_Intron	NM_022157	NP_071440	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	40					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				acccctccgcccgccgccgccgc	0.468																		2	4	---	---								-	39325200	CCG	-	39325198	7	5	19	1	0	1	0	1	0	0	0	0	13674	623	22	0	1106	0	RRAGC	1	39325198	In_Frame_Del	DEL	CCG	TCGA-BT-A3PJ-01A-21D-A21Z-08	3023756	39325198	209925423	12	5122										
RLF	6018	broad.mit.edu	37	chr1	40705282	40705282	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtgacagtagtgcacccatCcagaacactgattgctgtca	10	11	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:40705282C>G	uc001cfc.3	+	8	4939	c.4908C>G	c.(4906-4908)ATC>ATG	p.I1636M	RLF_uc001cfd.3_Missense_Mutation_p.I1327M	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1636					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GTGCACCCATCCAGAACACTG	0.468													0	0	0	0.011902	0	37	57										G	40705282	C	G	40705282	3	3	19	1	0	0	0	0	1	0	0	0	13389	845	30	1	4938	1	RLF	1	40705282	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1380084	40705282	208545339	13	5123										
SMAP2	64744	broad.mit.edu	37	chr1	40875495	40875495	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atggaccgaagtctggacatCaatgcctttagggttggtta	12	7	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:40875495C>G	uc001cfj.2	+	4	455	c.390C>G	c.(388-390)ATC>ATG	p.I130M	SMAP2_uc010ojh.1_Missense_Mutation_p.I130M|SMAP2_uc001cfk.2_Missense_Mutation_p.I100M|SMAP2_uc010oji.1_Missense_Mutation_p.I47M	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	130	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			GTCTGGACATCAATGCCTTTA	0.373													0	0	0	0.007413	0	16	23										G	40875495	C	G	40875495	3	3	19	1	0	0	0	0	1	0	0	0	14767	816	29	1	404	1	SMAP2	1	40875495	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	170213	40875495	208375126	14	5124										
HIVEP3	59269	broad.mit.edu	37	chr1	42047045	42047045	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaaggagaaaagggagactgGtgggggcaggtatggcttct	19	4	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:42047045G>T	uc001cgz.3	-	4	4637	c.3424C>A	c.(3424-3426)CCA>ACA	p.P1142T	HIVEP3_uc001cha.3_Missense_Mutation_p.P1142T|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1142					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGGAGACTGGTGGGGGCAGG	0.602													1	0	1.05635e-38	0.01441	1.15518e-38	59	129										T	42047045	G	T	42047045	3	4	19	1	0	0	0	0	1	0	0	0	7188	1261	44	4	3820	4	HIVEP3	1	42047045	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1171550	42047045	207203576	15	5125										
PRDX1	5052	broad.mit.edu	37	chr1	45977057	45977057	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacatcaggcttgatggtatCactgccaggtttccagccag	11	11	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:45977057C>T	uc001cnz.2	-	5	576	c.544G>A	c.(544-546)GAT>AAT	p.D182N	PRDX1_uc001coa.2_Missense_Mutation_p.D182N|PRDX1_uc001cob.2_Missense_Mutation_p.D182N|PRDX1_uc001coc.2_Missense_Mutation_p.D182N	NM_181697	NP_859048	Q06830	PRDX1_HUMAN	peroxiredoxin 1	182					cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity				0	Acute lymphoblastic leukemia(166;0.155)					TTGATGGTATCACTGCCAGGT	0.493													0	0	0	0.01441	0	157	279										T	45977057	C	T	45977057	3	4	19	1	0	0	0	0	1	0	0	0	12464	826	29	1	59	1	PRDX1	1	45977057	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3930012	45977057	203273564	16	5126										
ACOT11	26027	broad.mit.edu	37	chr1	55066985	55066985	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggcctatcgccaggaggctGagacccaccggcgccacatc	12	16	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:55066985G>A	uc001cxm.1	+	9	1010	c.928G>A	c.(928-930)GAG>AAG	p.E310K	ACOT11_uc001cxj.1_Missense_Mutation_p.E188K|ACOT11_uc001cxl.1_Missense_Mutation_p.E310K	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	310	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CCAGGAGGCTGAGACCCACCG	0.642													0	0	0	0.011902	0	40	99										A	55066985	G	A	55066985	3	1	19	1	0	0	0	0	1	0	0	0	149	1291	45	1	962	1	ACOT11	1	55066985	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	9089928	55066985	194183636	17	5127										
DOCK7	85440	broad.mit.edu	37	chr1	62993932	62993932	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccgctctcactttcataatCatcagtggctatacaaattg	5	11	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:62993932C>T	uc001daq.2	-	31	3860	c.3826G>A	c.(3826-3828)GAT>AAT	p.D1276N	DOCK7_uc001dan.2_Missense_Mutation_p.D1137N|DOCK7_uc001dao.2_Missense_Mutation_p.D1137N|DOCK7_uc001dap.2_Missense_Mutation_p.D1245N|DOCK7_uc001dam.2_Missense_Mutation_p.D456N|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1276					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTTTCATAATCATCAGTGGCT	0.408													0	0	0	0.001855	0	14	22										T	62993932	C	T	62993932	3	4	19	1	0	0	0	0	1	0	0	0	4692	826	29	1	2676	1	DOCK7	1	62993932	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	7926947	62993932	186256689	18	5128										
ROR1	4919	broad.mit.edu	37	chr1	64643839	64643839	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caggaagtgattgagatggtGagaaaacggcagctcttacc	13	7	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:64643839G>A	uc001dbj.2	+	9	2514	c.2115G>A	c.(2113-2115)GTG>GTA	p.V705V	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	705	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TTGAGATGGTGAGAAAACGGC	0.458													0	0	0	0.014323	0	23	58										A	64643839	G	A	64643839	2	1	19	1	0	0	0	0	0	0	0	1	13526	1277	45	1		1	ROR1	1	64643839	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1649907	64643839	184606782	19	5129										
SYDE2	84144	broad.mit.edu	37	chr1	85624533	85624533	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctttgagattgttttttcgaTccactgtagactcaactgtc	7	9	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:85624533T>A	uc009wcm.2	-	7	3534	c.3485A>T	c.(3484-3486)GAT>GTT	p.D1162V		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1162					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GTTTTTTCGATCCACTGTAGA	0.363													0	0	0	0.00308	0	5	9										A	85624533	T	A	85624533	3	1	19	1	0	0	0	0	1	0	0	0	15433	1435	50	5	103	5	SYDE2	1	85624533	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	20980694	85624533	163626088	20	5130										
BRDT	676	broad.mit.edu	37	chr1	92433810	92433810	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtgggtgttaaggaaagaatCaagaaaggtaaggcaggagg	17	2	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:92433810C>A	uc001dok.3	+	4	787	c.438C>A	c.(436-438)ATC>ATA	p.I146I	BRDT_uc001dol.3_Silent_p.I146I|BRDT_uc010osz.1_Silent_p.I146I|BRDT_uc009wdf.2_Silent_p.I73I|BRDT_uc010ota.1_Silent_p.I100I|BRDT_uc010otb.1_Silent_p.I100I|BRDT_uc001dom.3_Silent_p.I146I	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AGGAAAGAATCAAGAAAGGTA	0.398													1	0	7.93312e-07	0.00245	8.18569e-07	12	15										A	92433810	C	A	92433810	2	1	19	1	0	0	0	0	0	0	0	1	1508	816	29	3		3	BRDT	1	92433810	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6809277	92433810	156816811	21	5131										
ABCA4	24	broad.mit.edu	37	chr1	94461703	94461703	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccagcagctcgagggtgcaGagggaggtcatgactttcag	15	9	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:94461703G>C	uc001dqh.2	-	49	6882	c.6778C>G	c.(6778-6780)CTG>GTG	p.L2260V		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2260	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGAGGGTGCAGAGGGAGGTCA	0.517													0	0	0	0.004656	0	22	64										C	94461703	G	C	94461703	3	2	19	1	0	0	0	0	1	0	0	0	34	933	33	1	51	1	ABCA4	1	94461703	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2027893	94461703	154788918	22	5132										
CELSR2	1952	broad.mit.edu	37	chr1	109793958	109793958	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actccaggggccccagtactCcgagtcacagcctcggatcg	11	16	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:109793958C>G	uc001dxa.3	+	1	1318	c.1257C>G	c.(1255-1257)CTC>CTG	p.L419L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	419	Cadherin 3.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCCCAGTACTCCGAGTCACAG	0.547													0	0	0	0.01441	0	62	85										G	109793958	C	G	109793958	2	3	19	1	0	0	0	0	0	0	0	1	3222	842	30	1		1	CELSR2	1	109793958	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	15332255	109793958	139456663	23	5133										
CELSR2	1952	broad.mit.edu	37	chr1	109795716	109795716	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acgtcagctcctctggtgagCcgggctacagtccacgtccg	12	15	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:109795716C>T	uc001dxa.3	+	1	3076	c.3015C>T	c.(3013-3015)AGC>AGT	p.S1005S		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1005	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCTGGTGAGCCGGGCTACAG	0.567													0	0	0	0.00499	0	15	67										T	109795716	C	T	109795716	2	4	19	1	0	0	0	0	0	0	0	1	3222	738	26	2		2	CELSR2	1	109795716	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1758	109795716	139454905	24	5134										
MAGI3	260425	broad.mit.edu	37	chr1	114226131	114226131	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attattagagggtaagagtcGaagaatagcaggctatacgg	13	4	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:114226131G>A	uc001edk.2	+	21	4122	c.3941G>A	c.(3940-3942)CGA>CAA	p.R1314Q	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1339					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTAAGAGTCGAAGAATAGCA	0.453													0	0	0	0.004878	0	31	69										A	114226131	G	A	114226131	3	1	19	1	0	0	0	0	1	0	0	0	9192	1058	37	1	4077	1	MAGI3	1	114226131	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4430415	114226131	135024490	25	5135										
WDR3	10885	broad.mit.edu	37	chr1	118494605	118494605	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tttatttctcataggatggaGcactcatagcaactggctcc	8	10	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:118494605G>A	uc010oxe.1	+	17	1876	c.1810G>A	c.(1810-1812)GCA>ACA	p.A604T	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	604	WD 11.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		ATAGGATGGAGCACTCATAGC	0.383													0	0	0	0.004672	0	3	96										A	118494605	G	A	118494605	3	1	19	1	0	0	0	0	1	0	0	0	17282	971	34	2	1872	2	WDR3	1	118494605	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4268474	118494605	130756016	26	5136										
HSD3B2	3284	broad.mit.edu	37	chr1	119958115	119958115	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcgtccgcctgttggtggaaGagaaggaactgaaggagatc	15	7	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:119958115G>C	uc001ehs.2	+	1	846	c.73G>C	c.(73-75)GAG>CAG	p.E25Q	HSD3B2_uc001eht.2_Missense_Mutation_p.E25Q|HSD3B2_uc001ehu.2_Missense_Mutation_p.E25Q	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	25					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GTTGGTGGAAGAGAAGGAACT	0.522													0	0	0	0.007413	0	18	73										C	119958115	G	C	119958115	3	2	19	1	0	0	0	0	1	0	0	0	7391	943	33	1	75	1	HSD3B2	1	119958115	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1463510	119958115	129292506	27	5137										
SEC22B	9554	broad.mit.edu	37	chr1	145109581	145109581	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgtgaagctgccttccctaaGacgttggcttttgcctacct	9	12	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:145109581G>A	uc001eml.1	+	5	383	c.243G>A	c.(241-243)AAG>AAA	p.K81K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	81	Longin.|Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						CCTTCCCTAAGACGTTGGCTT	0.423													0	0	0	0.003271	0	35	350										A	145109581	G	A	145109581	2	1	19	1	0	0	0	0	0	0	0	1	13989	933	33	1		1	SEC22B	1	145109581	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	25151466	145109581	104141040	28	5138										
HRNR	388697	broad.mit.edu	37	chr1	152187575	152187575	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taggggaatggccagatccaGacccttgtcggccgtggccc	14	13	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:152187575G>A	uc001ezt.1	-	3	6606	c.6530C>T	c.(6529-6531)TCT>TTT	p.S2177F		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2177	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGATCCAGACCCTTGTCG	0.637													0	0	0	0.01441	0	36	295										A	152187575	G	A	152187575	3	1	19	1	0	0	0	0	1	0	0	0	7359	942	33	1	2026	1	HRNR	1	152187575	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7077994	152187575	97063046	29	5139										
HRNR	388697	broad.mit.edu	37	chr1	152192129	152192129	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	catgtcggccgcgactaggaGactggccagatccagagccc	13	14	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:152192129G>C	uc001ezt.1	-	3	2052	c.1976C>G	c.(1975-1977)TCT>TGT	p.S659C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	659	6.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGACTAGGAGACTGGCCAGA	0.592													0	0	0	0.00308	0	8	284										C	152192129	G	C	152192129	3	2	19	1	0	0	0	0	1	0	0	0	7359	942	33	1	6580	1	HRNR	1	152192129	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4554	152192129	97058492	30	5140										
FLAD1	80308	broad.mit.edu	37	chr1	154962840	154962840	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atctgcagatgttggaagctGagggcagcatgaagcaggcc	15	8	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:154962840G>C	uc001fgf.1	+	5	1744	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	FLAD1_uc001fgd.1_3'UTR|FLAD1_uc001fge.1_Missense_Mutation_p.E367Q|FLAD1_uc001fgg.1_Missense_Mutation_p.E367Q|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	464	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTTGGAAGCTGAGGGCAGCAT	0.602													0	0	0	0.003271	0	28	108										C	154962840	G	C	154962840	3	2	19	1	0	0	0	0	1	0	0	0	5920	1291	45	1	1548	1	FLAD1	1	154962840	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2770711	154962840	94287781	31	5141										
LMNA	4000	broad.mit.edu	37	chr1	156105709	156105709	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagctggcagccaaggaggcGaagcttcgagacctggagga	16	10	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156105709G>A	uc001fni.2	+	6	1203	c.954G>A	c.(952-954)GCG>GCA	p.A318A	LMNA_uc001fnf.1_Silent_p.A318A|LMNA_uc001fng.2_Silent_p.A318A|LMNA_uc001fnh.2_Silent_p.A318A|LMNA_uc009wro.1_Silent_p.A318A|LMNA_uc010pgz.1_Silent_p.A206A|LMNA_uc001fnj.2_Silent_p.A237A|LMNA_uc001fnk.2_Silent_p.A219A|LMNA_uc009wrp.2_Missense_Mutation_p.R46Q|LMNA_uc010pha.1_5'UTR	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	318	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					CCAAGGAGGCGAAGCTTCGAG	0.657									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				0	0	0	0.010504	0	19	41										A	156105709	G	A	156105709	2	1	19	1	0	0	0	0	0	0	0	1	8848	1045	37	1		1	LMNA	1	156105709	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1142869	156105709	93144912	32	5142										
HAPLN2	60484	broad.mit.edu	37	chr1	156593740	156593740	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggagcaaggtggagcctgGggagctccgggaaacgctga	18	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156593740G>C	uc001fpn.1	+	4	634	c.227G>C	c.(226-228)GGG>GCG	p.G76A	HAPLN2_uc010phq.1_Missense_Mutation_p.G76A	NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	76	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGGAGCCTGGGGAGCTCCGG	0.682													0	0	0	0.00278	0	20	9										C	156593740	G	C	156593740	3	2	19	1	0	0	0	0	1	0	0	0	6955	1232	43	4	233	4	HAPLN2	1	156593740	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	488031	156593740	92656881	33	5143										
HAPLN2	60484	broad.mit.edu	37	chr1	156594201	156594201	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagttcaattactacgaggcGaagcaggcgtgcgaggagca	14	9	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156594201G>A	uc001fpn.1	+	5	905	c.498G>A	c.(496-498)GCG>GCA	p.A166A		NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	166	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACTACGAGGCGAAGCAGGCGT	0.672													0	0	0	0.004007	0	13	27										A	156594201	G	A	156594201	2	1	19	1	0	0	0	0	0	0	0	1	6955	1045	37	1		1	HAPLN2	1	156594201	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	461	156594201	92656420	34	5144										
CD1A	909	broad.mit.edu	37	chr1	158226040	158226040	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acgtttcatcttgggtcttcTtgatgcaggaaaggcacatc	10	9	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:158226040T>C	uc001frt.2	+	3	1105	c.572T>C	c.(571-573)CTT>CCT	p.L191P		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	191	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TTGGGTCTTCTTGATGCAGGA	0.468													0	0	0	0.01441	0	37	116										C	158226040	T	C	158226040	3	2	19	1	0	0	0	0	1	0	0	0	2974	1609	56	5	582	5	CD1A	1	158226040	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1631839	158226040	91024581	35	5145										
OR10Z1	128368	broad.mit.edu	37	chr1	158576243	158576243	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcagaatggggcagaccaaCgtaacctcctggagggattt	12	10	1	2	rs140704584	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:158576243C>G	uc010pio.1	+	1	15	c.15C>G	c.(13-15)AAC>AAG	p.N5K		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					GGCAGACCAACGTAACCTCCT	0.468													0	0	0	0.001168	0	6	66										G	158576243	C	G	158576243	3	3	19	1	0	0	0	0	1	0	0	0	10923	535	19	4	17	4	OR10Z1	1	158576243	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	350203	158576243	90674378	36	5146										
NCSTN	23385	broad.mit.edu	37	chr1	160328025	160328025	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gccaaagctgatgtccttttCattgctccccgggagccagg	11	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:160328025C>T	uc001fvx.2	+	17	2218	c.2094C>T	c.(2092-2094)TTC>TTT	p.F698F	NCSTN_uc001fvy.2_Silent_p.F678F|NCSTN_uc010pjf.1_Silent_p.F560F|NCSTN_uc001fvz.2_Silent_p.F478F|NCSTN_uc010pjg.1_Silent_p.F440F	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	698	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGTCCTTTTCATTGCTCCCC	0.557													0	0	0	0.01441	0	51	601										T	160328025	C	T	160328025	2	4	19	1	0	0	0	0	0	0	0	1	10241	825	29	1		1	NCSTN	1	160328025	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1751782	160328025	88922596	37	5147										
NOS1AP	9722	broad.mit.edu	37	chr1	162337159	162337159	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccaacacggacgagagcgagGagcgcgactcgtggtcccag	15	13	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:162337159G>T	uc001gbv.2	+	10	1810	c.1423G>T	c.(1423-1425)GAG>TAG	p.E475*	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Nonsense_Mutation_p.E470*|NOS1AP_uc009wut.1_Nonsense_Mutation_p.E180*	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	475					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CGAGAGCGAGGAGCGCGACTC	0.657													1	0	0.00198382	0.001984	0.00201778	7	97										T	162337159	G	T	162337159	4	4	19	1	0	0	0	0	0	1	0	0	10542	1175	41	3	1515	3	NOS1AP	1	162337159	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2009134	162337159	86913462	38	5148										
TEDDM1	127670	broad.mit.edu	37	chr1	182368982	182368982	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagaagccatagattcccaaCaggaatgaggcattgatcat	10	8	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:182368982C>T	uc001gpe.2	-	1	770	c.639G>A	c.(637-639)CTG>CTA	p.L213L		NM_172000	NP_741997	Q5T9Z0	TEDM1_HUMAN	putative membrane protein HE9	213	Helical; (Potential).					integral to membrane				ovary(2)	2						AGATTCCCAACAGGAATGAGG	0.488													0	0	0	0.007413	0	18	25										T	182368982	C	T	182368982	2	4	19	1	0	0	0	0	0	0	0	1	15746	465	17	2		2	TEDDM1	1	182368982	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	20031823	182368982	66881639	39	5149										
LAMC1	3915	broad.mit.edu	37	chr1	183086502	183086502	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagatggctctgaagcatctCtcgagtggtcctctgagagg	14	9	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:183086502C>G	uc001gpy.3	+	9	1869	c.1612C>G	c.(1612-1614)CTC>GTC	p.L538V		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	538	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAAGCATCTCTCGAGTGGTC	0.488													0	0	0	0.007291	0	24	15										G	183086502	C	G	183086502	3	3	19	1	0	0	0	0	1	0	0	0	8614	913	32	1	1646	1	LAMC1	1	183086502	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	717520	183086502	66164119	40	5150										
CACNA1S	779	broad.mit.edu	37	chr1	201030503	201030503	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgaagaaggcaatgaggatGatgtagatgatgaagaagat	14	1	0	9			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:201030503G>A	uc001gvv.2	-	25	3374	c.3147C>T	c.(3145-3147)ATC>ATT	p.I1049I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1049	III.|Helical; Name=S6 of repeat III; (Potential).|Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAATGAGGATGATGTAGATGA	0.512													0	0	0	0.012213	0	32	33										A	201030503	G	A	201030503	2	1	19	1	0	0	0	0	0	0	0	1	2547	1280	45	1		1	CACNA1S	1	201030503	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	17944001	201030503	48220118	41	5151										
CTSE	1510	broad.mit.edu	37	chr1	206320303	206320303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagcttgtccgggatcattgGagccgaccaagtctctgtga	13	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:206320303G>A	uc001hdu.2	+	4	564	c.446G>A	c.(445-447)GGA>GAA	p.G149E	CTSE_uc001hdv.2_Missense_Mutation_p.G149E|CTSE_uc010prs.1_Missense_Mutation_p.G74E	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	149					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GGGATCATTGGAGCCGACCAA	0.493													0	0	0	0.013726	0	30	35										A	206320303	G	A	206320303	3	1	19	1	0	0	0	0	1	0	0	0	4033	1174	41	1	460	1	CTSE	1	206320303	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5289800	206320303	42930318	42	5152										
IL24	11009	broad.mit.edu	37	chr1	207072706	207072706	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcgacagcctctcaaatgcAgatggttgtgctcccttgcc	11	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:207072706A>G	uc001hes.1	+	3	360	c.86A>G	c.(85-87)CAG>CGG	p.Q29R	IL24_uc001het.1_Intron|IL24_uc001heu.1_Missense_Mutation_p.Q30R|IL24_uc001hev.1_Intron|IL24_uc001hew.1_Missense_Mutation_p.Q30R|IL24_uc001hex.1_Intron	NM_006850	NP_006841	Q13007	IL24_HUMAN	interleukin 24 isoform 1 precursor	29					apoptosis	extracellular space	cytokine activity				0	Breast(84;0.201)					TCTCAAATGCAGATGGTTGTG	0.587													0	0	0	0.010771	0	38	29										G	207072706	A	G	207072706	3	3	19	1	0	0	0	0	1	0	0	0	7677	188	7	5	95	5	IL24	1	207072706	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	752403	207072706	42177915	43	5153										
PFKFB2	5208	broad.mit.edu	37	chr1	207241622	207241622	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatctctcggggtgccctatGagcagtggaagattctgaat	12	8	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:207241622G>A	uc001hfg.2	+	10	1064	c.955G>A	c.(955-957)GAG>AAG	p.E319K	PFKFB2_uc010psc.1_Missense_Mutation_p.E221K|PFKFB2_uc001hfh.2_Missense_Mutation_p.E319K|PFKFB2_uc009xcc.2_Missense_Mutation_p.E277K|PFKFB2_uc010psd.1_Missense_Mutation_p.E133K	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	319	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					GGTGCCCTATGAGCAGTGGAA	0.473													0	0	0	0.006122	0	17	12										A	207241622	G	A	207241622	3	1	19	1	0	0	0	0	1	0	0	0	11761	1291	45	1	989	1	PFKFB2	1	207241622	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	168916	207241622	42008999	44	5154										
USH2A	7399	broad.mit.edu	37	chr1	216062088	216062088	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatcacagatgttggagtatCagagaacagctctggacttg	11	7	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:216062088C>T	uc001hku.1	-	41	8290	c.7903G>A	c.(7903-7905)GAT>AAT	p.D2635N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2635	Extracellular (Potential).|Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTGGAGTATCAGAGAACAGC	0.498										HNSCC(13;0.011)			0	0	0	0.00245	0	15	21										T	216062088	C	T	216062088	3	4	19	1	0	0	0	0	1	0	0	0	17033	826	29	1	7833	1	USH2A	1	216062088	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8820466	216062088	33188533	45	5155										
NVL	4931	broad.mit.edu	37	chr1	224420909	224420909	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggagagaattgtacctttttCatttccactcttctgtcttg	7	9	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:224420909C>G	uc001hok.2	-	21	2492	c.2449G>C	c.(2449-2451)GAA>CAA	p.E817Q	NVL_uc001hol.2_Missense_Mutation_p.E711Q|NVL_uc010pvd.1_Missense_Mutation_p.E726Q|NVL_uc010pve.1_Missense_Mutation_p.E628Q|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	817						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		GTACCTTTTTCATTTCCACTC	0.383													0	0	0	0.008871	0	18	57										G	224420909	C	G	224420909	3	3	19	1	0	0	0	0	1	0	0	0	10780	835	29	1	133	1	NVL	1	224420909	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8358821	224420909	24829712	46	5156										
NVL	4931	broad.mit.edu	37	chr1	224477270	224477270	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccatttcaggatttttcttCtgctgttcctgtagcttcat	6	10	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:224477270C>T	uc001hok.2	-	13	1534	c.1491G>A	c.(1489-1491)CAG>CAA	p.Q497Q	NVL_uc001hol.2_Silent_p.Q391Q|NVL_uc010pvd.1_Silent_p.Q406Q|NVL_uc010pve.1_Silent_p.Q308Q|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	497						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		GATTTTTCTTCTGCTGTTCCT	0.473													0	0	0	0.014323	0	23	35										T	224477270	C	T	224477270	2	4	19	1	0	0	0	0	0	0	0	1	10780	912	32	1		1	NVL	1	224477270	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	56361	224477270	24773351	47	5157										
PSEN2	5664	broad.mit.edu	37	chr1	227071519	227071519	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgaccctcaaatacggagcGaagcacgtgatcatgctgtt	10	11	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:227071519G>A	uc009xeo.1	+	5	682	c.255G>A	c.(253-255)GCG>GCA	p.A85A	PSEN2_uc009xep.1_Silent_p.A85A|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	85	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				AATACGGAGCGAAGCACGTGA	0.582													0	0	0	0.004878	0	34	131										A	227071519	G	A	227071519	2	1	19	1	0	0	0	0	0	0	0	1	12651	1045	37	1		1	PSEN2	1	227071519	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2594249	227071519	22179102	48	5158										
LYST	1130	broad.mit.edu	37	chr1	235972637	235972637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctttttcttgtacacatcGaatgatgaagttgctctgat	8	8	2	3	rs115019462	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:235972637G>A	uc001hxj.2	-	5	1656	c.1481C>T	c.(1480-1482)TCG>TTG	p.S494L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.S494L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	494					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGTACACATCGAATGATGAAG	0.398									Chediak-Higashi_syndrome				0	0	0	0.00632	0	26	47										A	235972637	G	A	235972637	3	1	19	1	0	0	0	0	1	0	0	0	9128	1059	37	1	10120	1	LYST	1	235972637	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	8901118	235972637	13277984	49	5159										
MYT1L	23040	broad.mit.edu	37	chr2	1855420	1855420	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	catctctacatacctccgatGagaagcataattgccggtga	8	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:1855420G>A	uc002qxe.2	-	19	3594	c.2767C>T	c.(2767-2769)CAT>TAT	p.H923Y	MYT1L_uc002qxd.2_Missense_Mutation_p.H921Y	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	923	C2HC-type 4.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TACCTCCGATGAGAAGCATAA	0.433													0	0	0	0.01441	0	49	110										A	1855420	G	A	1855420	3	1	19	1	0	0	0	0	1	0	0	0	10107	1290	45	1	821	1	MYT1L	2	1855420	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		1855420	241343953	50	5160										
RHOB	388	broad.mit.edu	37	chr2	20647266	20647266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agctggtggtggtgggcgacGgcgcgtgtggcaagacgtgc	21	8	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:20647266G>A	uc002rdv.2	+	1	432	c.40G>A	c.(40-42)GGC>AGC	p.G14S		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	14	GTP (By similarity).			G->V: No effect on internalization of EGF receptor but decreases trafficking of receptor to the lysosome with associated accumulation in late endosomes.	angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GGTGGGCGACGGCGCGTGTGG	0.677													0	0	0	0.010818	0	28	72										A	20647266	G	A	20647266	3	1	19	1	0	0	0	0	1	0	0	0	13332	1116	39	2	42	2	RHOB	2	20647266	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	18791846	20647266	222552107	51	5161										
ITSN2	50618	broad.mit.edu	37	chr2	24538094	24538094	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcccacatgtttggccctcCtgaaacataagtggaagaaa	9	10	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:24538094C>T	uc002rfe.2	-	3	290	c.32_splice	c.e3-1	p.G11_splice	ITSN2_uc002rff.2_Splice_Site_p.G11_splice|ITSN2_uc002rfg.2_Splice_Site_p.G11_splice|ITSN2_uc010eyd.2_Splice_Site_p.G11_splice	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGGCCCTCCTGAAACATAA	0.358													0	0	0	0.003163	0	14	43										T	24538094	C	T	24538094	5	4	19	1	0	0	0	0	0	0	1	0	7927	695	24	2	5265	2	ITSN2	2	24538094	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3890828	24538094	218661279	52	5162										
C2orf70	339778	broad.mit.edu	37	chr2	26799014	26799014	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcttcaacctggacagccatCgctccacagagcttacgaat	8	14	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:26799014C>T	uc010eyn.2	+	2	319	c.319C>T	c.(319-321)CGC>TGC	p.R107C		NM_001105519	NP_001098989	A6NJV1	CB070_HUMAN	hypothetical protein LOC339778	107										skin(1)	1						GGACAGCCATCGCTCCACAGA	0.637													0	0	0	0.01441	0	81	113										T	26799014	C	T	26799014	3	4	19	1	0	0	0	0	1	0	0	0	2190	884	31	1	325	1	C2orf70	2	26799014	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2260920	26799014	216400359	53	5163										
FOSL2	2355	broad.mit.edu	37	chr2	28635076	28635076	+	Frame_Shift_Del	DEL	C	C	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cccagcgctctgtcatcaagCccatcagcattgctgggggc							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:28635076delC	uc002rma.2	+	4	1551	c.742delC	c.(742-744)CCCfs	p.P248fs	FOSL2_uc010ymi.1_Frame_Shift_Del_p.P209fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	248					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGTCATCAAGCCCATCAGCAT	0.652																		22	65	---	---								-	28635076	C	-	28635076	7	5	19	1	0	1	0	1	0	0	0	0	5988	739	26	0	756	0	FOSL2	2	28635076	Frame_Shift_Del	DEL	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1836062	28635076	214564297	54	5164										
BIRC6	57448	broad.mit.edu	37	chr2	32832645	32832645	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagaatatgatggaaacattCgacaagcaacagttaagtgg	11	5	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:32832645C>T	uc010ezu.2	+	72	14328	c.14194C>T	c.(14194-14196)CGA>TGA	p.R4732*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4732					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGGAAACATTCGACAAGCAAC	0.378													0	0	0	0.009535	0	31	52										T	32832645	C	T	32832645	4	4	19	1	0	0	0	0	0	1	0	0	1438	876	31	1	14480	1	BIRC6	2	32832645	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4197569	32832645	210366728	55	5165										
FAM98A	25940	broad.mit.edu	37	chr2	33813494	33813494	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acatatgcctttcaactcttGaaagacctcactaccgcctc	4	15	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:33813494G>A	uc002rpa.1	-	4	504	c.430C>T	c.(430-432)CAA>TAA	p.Q144*	FAM98A_uc010yne.1_Intron|FAM98A_uc010ynd.1_5'Flank|FAM98A_uc002roz.1_Nonsense_Mutation_p.Q21*	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	144										ovary(1)	1	all_hematologic(175;0.115)					TTCAACTCTTGAAAGACCTCA	0.423													0	0	0	0.00623	0	35	87										A	33813494	G	A	33813494	4	1	19	1	0	0	0	0	0	1	0	0	5656	1299	45	1	1146	1	FAM98A	2	33813494	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	980849	33813494	209385879	56	5166										
ZFP36L2	678	broad.mit.edu	37	chr2	43452474	43452474	+	Missense_Mutation	SNP	C	C	T													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcgaagggccggcacagctCggtcttgtagcgcgtggagt							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:43452474C>T	uc002rsv.3	-	2	760	c.469G>A	c.(469-471)GAG>AAG	p.E157K	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	157	C3H1-type 1.|RNA-binding.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CGGCACAGCTCGGTCTTGTAG	0.652													0	0	0	0.013537	0	12	45										T	43452474	C	T	43452474	3	4	19	1	0	0	0	0	1	0	0	0	17644	893	31	1	1019	1	ZFP36L2	2	43452474	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9638980	43452474	199746899	57	5167	25	2								
ZFP36L2	678	broad.mit.edu	37	chr2	43452478	43452478	+	Missense_Mutation	SNP	C	C	G													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagggccggcacagctcggtCttgtagcgcgtggagttgat							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:43452478C>G	uc002rsv.3	-	2	756	c.465G>C	c.(463-465)AAG>AAC	p.K155N	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	155	C3H1-type 1.|RNA-binding.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				ACAGCTCGGTCTTGTAGCGCG	0.657													0	0	0	0.010729	0	11	47										G	43452478	C	G	43452478	3	3	19	1	0	0	0	0	1	0	0	0	17644	912	32	1	1023	1	ZFP36L2	2	43452478	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4	43452478	199746895	58	5168	25	2								
ATP6V1E2	90423	broad.mit.edu	37	chr2	46739578	46739578	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctcactgagcaaatctgaGatgaggtcatttcgggctct	11	10	4	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:46739578G>C	uc002ruy.2	-	2	1387	c.273C>G	c.(271-273)ATC>ATG	p.I91M	ATP6V1E2_uc002ruz.2_Missense_Mutation_p.I91M	NM_080653	NP_542384	Q96A05	VATE2_HUMAN	ATPase, H+ transporting, lysosomal 31kDa, V1	91					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain	proton-transporting ATPase activity, rotational mechanism			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.151)			GCAAATCTGAGATGAGGTCAT	0.527													0	0	0	0.003755	0	29	70										C	46739578	G	C	46739578	3	2	19	1	0	0	0	0	1	0	0	0	1184	932	33	1	411	1	ATP6V1E2	2	46739578	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3287100	46739578	196459795	59	5169										
SPTBN1	6711	broad.mit.edu	37	chr2	54848571	54848571	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	catcctgatgagaagtccatAatcacttatgtggtgactta	8	8	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:54848571A>T	uc002rxu.2	+	8	1047	c.798A>T	c.(796-798)ATA>ATT	p.I266I	SPTBN1_uc002rxv.1_Silent_p.I266I|SPTBN1_uc002rxx.2_Silent_p.I253I	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	266	CH 2.|Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGAAGTCCATAATCACTTATG	0.463													0	0	0	0.004878	0	33	72										T	54848571	A	T	54848571	2	4	19	1	0	0	0	0	0	0	0	1	15118	352	13	5		5	SPTBN1	2	54848571	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	8108993	54848571	188350802	60	5170										
REG3A	5068	broad.mit.edu	37	chr2	79385578	79385578	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggtttccagagggccgcttCtggcaggccagctttgaggg	16	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:79385578C>T	uc002sod.1	-	3	462	c.207G>A	c.(205-207)CAG>CAA	p.Q69Q	REG3A_uc002soe.1_Silent_p.Q69Q|REG3A_uc002sof.1_Silent_p.Q69Q	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	69	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						AGGGCCGCTTCTGGCAGGCCA	0.572													0	0	0	0.005524	0	32	76										T	79385578	C	T	79385578	2	4	19	1	0	0	0	0	0	0	0	1	13212	912	32	1		1	REG3A	2	79385578	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	24537007	79385578	163813795	61	5171										
LRRTM1	347730	broad.mit.edu	37	chr2	80530727	80530727	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctccgagaggctgttgtagCgcagggacaagcccagcagg	16	11	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:80530727C>T	uc002sok.1	-	2	488	c.218G>A	c.(217-219)CGC>CAC	p.R73H	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	73	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCTGTTGTAGCGCAGGGACAA	0.662										HNSCC(69;0.2)			0	0	0	0.01441	0	48	114										T	80530727	C	T	80530727	3	4	19	1	0	0	0	0	1	0	0	0	9039	768	27	2	1354	2	LRRTM1	2	80530727	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1145149	80530727	162668646	62	5172										
POLR1A	25885	broad.mit.edu	37	chr2	86305369	86305369	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gactggcctggaagtgtactCaaaaaggatcggtcaatagc	12	8	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:86305369C>T	uc002sqs.2	-	10	1504	c.1125G>A	c.(1123-1125)TTG>TTA	p.L375L	POLR1A_uc002sqv.2_Silent_p.L375L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	375					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GAAGTGTACTCAAAAAGGATC	0.423													0	0	0	0.00333	0	22	41										T	86305369	C	T	86305369	2	4	19	1	0	0	0	0	0	0	0	1	12209	825	29	1		1	POLR1A	2	86305369	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5774642	86305369	156894004	63	5173										
ANKRD36	375248	broad.mit.edu	37	chr2	97779539	97779539	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgcttgtgctcggatggcttCgcatttccccaataccccat	8	15	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:97779539C>G	uc010yva.1	+	1	307	c.63C>G	c.(61-63)TTC>TTG	p.F21L	ANKRD36_uc002sxn.2_Missense_Mutation_p.F21L|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.F21L|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21											0						CGGATGGCTTCGCATTTCCCC	0.512													0	0	0	0.01441	0	54	90										G	97779539	C	G	97779539	3	3	19	1	0	0	0	0	1	0	0	0	665	883	31	1	65	1	ANKRD36	2	97779539	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	11474170	97779539	145419834	64	5174										
EIF5B	9669	broad.mit.edu	37	chr2	99998633	99998633	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgtttctagtttgatagagaGaatgtacggattccaggaat	11	4	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:99998633G>C	uc002tab.2	+	13	2257	c.2073G>C	c.(2071-2073)GAG>GAC	p.E691D		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	691					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TTGATAGAGAGAATGTACGGA	0.353													0	0	0	0.006214	0	8	53										C	99998633	G	C	99998633	3	2	19	1	0	0	0	0	1	0	0	0	5044	933	33	1	2123	1	EIF5B	2	99998633	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2219094	99998633	143200740	65	5175										
SLC5A7	60482	broad.mit.edu	37	chr2	108608587	108608587	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgggtcggaggagggtatatCaatggcacagctgaagcagt	16	6	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:108608587C>T	uc002tdv.2	+	3	480	c.204C>T	c.(202-204)ATC>ATT	p.I68I	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Silent_p.I68I|SLC5A7_uc010ywn.1_5'UTR	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	68	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GAGGGTATATCAATGGCACAG	0.393													0	0	0	0.011902	0	34	75										T	108608587	C	T	108608587	2	4	19	1	0	0	0	0	0	0	0	1	14670	816	29	1		1	SLC5A7	2	108608587	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8609954	108608587	134590786	66	5176										
RANBP2	5903	broad.mit.edu	37	chr2	109398640	109398640	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttgtttaaagagagagccaaActttatagatgggatcggga	12	4	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:109398640A>G	uc002tem.3	+	27	8943	c.8817A>G	c.(8815-8817)AAA>AAG	p.K2939K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2939	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AGAGAGCCAAACTTTATAGAT	0.363													0	0	0	0.010504	0	17	28										G	109398640	A	G	109398640	2	3	19	1	0	0	0	0	0	0	0	1	13028	40	2	5		5	RANBP2	2	109398640	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	790053	109398640	133800733	67	5177										
PSD4	23550	broad.mit.edu	37	chr2	113955352	113955352	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agaccactgtctggagggggAgagcttggtggggcagatgg	20	6	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:113955352A>G	uc002tjc.2	+	14	2669	c.2486A>G	c.(2485-2487)GAG>GGG	p.E829G	PSD4_uc002tjd.2_Missense_Mutation_p.E449G|PSD4_uc002tje.2_Missense_Mutation_p.E799G|PSD4_uc002tjf.2_Missense_Mutation_p.E450G|PSD4_uc002tjg.2_5'UTR|PSD4_uc010yxs.1_Missense_Mutation_p.E59G|PSD4_uc002tjh.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	829	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CTGGAGGGGGAGAGCTTGGTG	0.622													0	0	0	0.000602	0	3	107										G	113955352	A	G	113955352	3	3	19	1	0	0	0	0	1	0	0	0	12649	304	11	5	2536	5	PSD4	2	113955352	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	4556712	113955352	129244021	68	5178										
DPP10	57628	broad.mit.edu	37	chr2	116066832	116066832	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taggaactgggaagtaacagCcctccacagagaaactggaa	11	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:116066832C>T	uc002tla.1	+	2	535	c.78C>T	c.(76-78)AGC>AGT	p.S26S	DPP10_uc002tlb.1_5'UTR|DPP10_uc002tlc.1_Silent_p.S22S|DPP10_uc002tle.2_Silent_p.S30S|DPP10_uc002tlf.1_Silent_p.S19S	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	26	Mediates effects on KCND2.|Cytoplasmic (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GAAGTAACAGCCCTCCACAGA	0.403													0	0	0	0.008871	0	19	24										T	116066832	C	T	116066832	2	4	19	1	0	0	0	0	0	0	0	1	4727	738	26	2		2	DPP10	2	116066832	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2111480	116066832	127132541	69	5179										
DPP10	57628	broad.mit.edu	37	chr2	116572442	116572442	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attccgtactcattgacatgGataatgtcattgtagcaaga	8	7	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:116572442G>A	uc002tla.1	+	20	2231	c.1774G>A	c.(1774-1776)GAT>AAT	p.D592N	DPP10_uc002tlb.1_Missense_Mutation_p.D542N|DPP10_uc002tlc.1_Missense_Mutation_p.D588N|DPP10_uc002tle.2_Missense_Mutation_p.D596N|DPP10_uc002tlf.1_Missense_Mutation_p.D585N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	592	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CATTGACATGGATAATGTCAT	0.413													0	0	0	0.00333	0	20	73										A	116572442	G	A	116572442	3	1	19	1	0	0	0	0	1	0	0	0	4727	1174	41	1	2023	1	DPP10	2	116572442	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	505610	116572442	126626931	70	5180										
WDR33	55339	broad.mit.edu	37	chr2	128467402	128467402	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctggggggagcacggccctCatgcctcggcggggctcctc	16	15	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:128467402C>T	uc002tpg.1	-	19	3520	c.3337G>A	c.(3337-3339)GAG>AAG	p.E1113K		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1113					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GCACGGCCCTCATGCCTCGGC	0.522													0	0	0	0.01441	0	73	130										T	128467402	C	T	128467402	3	4	19	1	0	0	0	0	1	0	0	0	17284	835	29	1	689	1	WDR33	2	128467402	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	11894960	128467402	114731971	71	5181										
WDR33	55339	broad.mit.edu	37	chr2	128482710	128482710	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gatatcaaaaagtttacagaGatgatcacgtgatgctgtga	10	5	2	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:128482710G>C	uc002tpg.1	-	9	1114	c.931C>G	c.(931-933)CTC>GTC	p.L311V		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	311	WD 5.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		AGTTTACAGAGATGATCACGT	0.383													0	0	0	0.010729	0	9	13										C	128482710	G	C	128482710	3	2	19	1	0	0	0	0	1	0	0	0	17284	942	33	1	3135	1	WDR33	2	128482710	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	15308	128482710	114716663	72	5182										
POTEF	728378	broad.mit.edu	37	chr2	130878029	130878029	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacttgcccatcttgctcctGagaccaaatggcttcttcac	6	15	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:130878029G>C	uc010fmh.2	-	3	460	c.60C>G	c.(58-60)CTC>CTG	p.L20L		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	20						cell cortex	ATP binding			skin(3)|ovary(2)	5						TCTTGCTCCTGAGACCAAATG	0.557													0	0	0	0.006999	0	23	146										C	130878029	G	C	130878029	2	2	19	1	0	0	0	0	0	0	0	1	12265	1277	45	1		1	POTEF	2	130878029	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2395319	130878029	112321344	73	5183										
CCDC115	84317	broad.mit.edu	37	chr2	131098587	131098587	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gactccggttctggggtcttAgtggggcccttgcgcctccg	15	13	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:131098587A>C	uc002tqy.1	-	4	548	c.324T>G	c.(322-324)ACT>ACG	p.T108T	CCDC115_uc002tqw.1_Silent_p.T100T|CCDC115_uc010zaf.1_Silent_p.T103T|CCDC115_uc002tqx.2_Silent_p.T103T|CCDC115_uc002tqz.1_Silent_p.T108T|IMP4_uc002tra.1_5'Flank	NM_032357	NP_115733	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	108						endosome|lysosome					0	Colorectal(110;0.1)					CTGGGGTCTTAGTGGGGCCCT	0.522													0	0	0	0.001168	0	5	17										C	131098587	A	C	131098587	2	2	19	1	0	0	0	0	0	0	0	1	2752	407	15	5		5	CCDC115	2	131098587	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	220558	131098587	112100786	74	5184										
FAM168B	130074	broad.mit.edu	37	chr2	131810476	131810476	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcacttacatttgcaggtgaTcaccactgagggggcacata	10	10	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:131810476T>C	uc002tsd.2	-	6	817	c.588A>G	c.(586-588)TGA>TGG	p.*196W		NM_001009993	NP_001009993	A1KXE4	F168B_HUMAN	hypothetical protein LOC130074	196											0						TTGCAGGTGATCACCACTGAG	0.557													0	0	0	0.009096	0	3	8										C	131810476	T	C	131810476	4	2	19	1	0	0	0	0	0	0	0	0	5486	1448	50	5	3	5	FAM168B	2	131810476	Nonstop_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	711889	131810476	111388897	75	5185										
GPR39	2863	broad.mit.edu	37	chr2	133174626	133174626	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctctttctcatggcttcacCcagcctcccgggcagtgact	9	16	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133174626C>T	uc002ttl.2	+	1	480	c.11C>T	c.(10-12)CCC>CTC	p.P4L		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	4	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						ATGGCTTCACCCAGCCTCCCG	0.517													0	0	0	0.003755	0	28	51										T	133174626	C	T	133174626	3	4	19	1	0	0	0	0	1	0	0	0	6693	623	22	2	13	2	GPR39	2	133174626	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1364150	133174626	110024747	76	5186										
NCKAP5	344148	broad.mit.edu	37	chr2	133531409	133531409	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctatgatgtggctctgaaatAcagaatctgcaactgcatcg	9	9	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133531409A>G	uc002ttp.2	-	16	5482	c.5108T>C	c.(5107-5109)GTA>GCA	p.V1703A	NCKAP5_uc002ttq.2_Missense_Mutation_p.V384A	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1703							protein binding				0						GCTCTGAAATACAGAATCTGC	0.343													0	0	0	0.01441	0	40	67										G	133531409	A	G	133531409	3	3	19	1	0	0	0	0	1	0	0	0	10223	391	14	5	641	5	NCKAP5	2	133531409	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	356783	133531409	109667964	77	5187										
NCKAP5	344148	broad.mit.edu	37	chr2	133721430	133721430	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttatgttttctctcttcctCtgacagcttttcctgaagca	5	12	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133721430C>T	uc002ttp.2	-	8	816	c.442G>A	c.(442-444)GAG>AAG	p.E148K	NCKAP5_uc002ttq.2_Missense_Mutation_p.E148K|NCKAP5_uc002tts.1_Missense_Mutation_p.E123K	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	148	Potential.						protein binding				0						CTCTCTTCCTCTGACAGCTTT	0.403													0	0	0	0.003163	0	14	83										T	133721430	C	T	133721430	3	4	19	1	0	0	0	0	1	0	0	0	10223	922	32	1	5339	1	NCKAP5	2	133721430	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	190021	133721430	109477943	78	5188										
ZEB2	9839	broad.mit.edu	37	chr2	145154073	145154073	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgccactctctgtcttcttGatctttttgcgagacagaca	7	11	4	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:145154073G>C	uc002tvu.2	-	9	3453	c.2973C>G	c.(2971-2973)ATC>ATG	p.I991M	ZEB2_uc002tvv.2_Missense_Mutation_p.I985M|ZEB2_uc010zbm.1_Missense_Mutation_p.I962M|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	991						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTGTCTTCTTGATCTTTTTGC	0.443													0	0	0	0.01441	0	56	91										C	145154073	G	C	145154073	3	2	19	1	0	0	0	0	1	0	0	0	17621	1280	45	1	679	1	ZEB2	2	145154073	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	11432643	145154073	98045300	79	5189										
GALNT13	114805	broad.mit.edu	37	chr2	155099224	155099224	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gttacagattttctcaagttGacattagagaattacgtgaa	8	5	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:155099224G>C	uc002tyr.3	+	6	1059	c.492G>C	c.(490-492)TTG>TTC	p.L164F	GALNT13_uc002tyt.3_Missense_Mutation_p.L164F|GALNT13_uc010foc.1_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	164	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TTCTCAAGTTGACATTAGAGA	0.338													0	0	0	0.010729	0	11	25										C	155099224	G	C	155099224	3	2	19	1	0	0	0	0	1	0	0	0	6211	1281	45	1	506	1	GALNT13	2	155099224	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	9945151	155099224	88100149	80	5190										
SCRN3	79634	broad.mit.edu	37	chr2	175263091	175263091	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gattatttttggaaaaaattCagatagactctatgatgaag	8	3	2	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:175263091C>G	uc002uiq.2	+	2	168	c.80C>G	c.(79-81)TCA>TGA	p.S27*	CIR1_uc002uim.2_5'Flank|CIR1_uc002uin.2_5'Flank|CIR1_uc002uio.2_5'Flank|CIR1_uc002uip.2_5'Flank|SCRN3_uc010zen.1_Intron|SCRN3_uc010zeo.1_5'UTR|SCRN3_uc002uir.1_RNA	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	27					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			GGAAAAAATTCAGATAGACTC	0.343													0	0	0	0.008871	0	18	96										G	175263091	C	G	175263091	4	3	19	1	0	0	0	0	0	1	0	0	13940	838	29	1	82	1	SCRN3	2	175263091	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	20163867	175263091	67936282	81	5191										
TTN	7273	broad.mit.edu	37	chr2	179480041	179480041	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attaaaaacctactttgtttCtgcaacaggttctccacagg	6	10	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:179480041C>T	uc010zfg.1	-	208	41151	c.40927G>A	c.(40927-40929)GAA>AAA	p.E13643K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E7338K|TTN_uc010zfi.1_Missense_Mutation_p.E7271K|TTN_uc010zfj.1_Missense_Mutation_p.E7146K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14570							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTTTGTTTCTGCAACAGGT	0.373													0	0	0	0.004656	0	23	36										T	179480041	C	T	179480041	3	4	19	1	0	0	0	0	1	0	0	0	16732	922	32	1	59478	1	TTN	2	179480041	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4216950	179480041	63719332	82	5192										
ANKAR	150709	broad.mit.edu	37	chr2	190593496	190593496	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tactaagaattagtacgattGctgaaggcacacttctcagt	8	8	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:190593496G>A	uc002uqw.1	+	14	2929	c.2929G>A	c.(2929-2931)GCT>ACT	p.A977T	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Missense_Mutation_p.A144T	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1048						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TAGTACGATTGCTGAAGGCAC	0.373													0	0	0	0.01441	0	55	28										A	190593496	G	A	190593496	3	1	19	1	0	0	0	0	1	0	0	0	623	1319	46	2	3196	2	ANKAR	2	190593496	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	11113455	190593496	52605877	83	5193										
MYO1B	4430	broad.mit.edu	37	chr2	192256914	192256914	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tagatcaaagatattcatccGaaacccaagaacagtatgta	6	8	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:192256914G>C	uc010fsg.2	+	19	2318	c.2063G>C	c.(2062-2064)CGA>CCA	p.R688P	MYO1B_uc002usq.2_Missense_Mutation_p.R688P|MYO1B_uc002usr.2_Missense_Mutation_p.R688P|MYO1B_uc002usu.2_5'UTR	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	688	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ATATTCATCCGAAACCCAAGA	0.303													0	0	0	0.004007	0	12	49										C	192256914	G	C	192256914	3	2	19	1	0	0	0	0	1	0	0	0	10069	1058	37	1	2133	1	MYO1B	2	192256914	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1663418	192256914	50942459	84	5194										
DNAH7	56171	broad.mit.edu	37	chr2	196729276	196729276	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagtagtatcataccccttaGagatttcaacttggaaaact	6	9	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:196729276G>C	uc002utj.3	-	41	7204	c.7103C>G	c.(7102-7104)TCT>TGT	p.S2368C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2368	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATACCCCTTAGAGATTTCAAC	0.448													0	0	0	0.013537	0	9	70										C	196729276	G	C	196729276	3	2	19	1	0	0	0	0	1	0	0	0	4606	942	33	1	5071	1	DNAH7	2	196729276	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4472362	196729276	46470097	85	5195										
CDK15	65061	broad.mit.edu	37	chr2	202744799	202744799	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggcctcccagatgctaaaAggctttcccagagaccgcgt	10	14	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:202744799A>C	uc002uyt.2	+	12	1156	c.1107A>C	c.(1105-1107)AAA>AAC	p.K369N	CDK15_uc002uys.2_Missense_Mutation_p.K318N|CDK15_uc010ftn.1_Missense_Mutation_p.K318N|CDK15_uc002uyu.1_RNA	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	369	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	AGATGCTAAAAGGCTTTCCCA	0.542													0	0	0	0.007413	0	16	53										C	202744799	A	C	202744799	3	2	19	1	0	0	0	0	1	0	0	0	3131	69	3	5	996	5	CDK15	2	202744799	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	6015523	202744799	40454574	86	5196										
NBEAL1	65065	broad.mit.edu	37	chr2	204078256	204078256	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctagcttgaatctcagcatCaacccattagccatgcgact	6	13	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204078256C>G	uc002uzt.3	+	54	8196	c.7863C>G	c.(7861-7863)ATC>ATG	p.I2621M	NBEAL1_uc002uzs.3_Missense_Mutation_p.I1262M|NBEAL1_uc002uzu.2_Missense_Mutation_p.I116M	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2621							binding			ovary(1)|skin(1)	2						ATCTCAGCATCAACCCATTAG	0.289													0	0	0	0.003163	0	14	97										G	204078256	C	G	204078256	3	3	19	1	0	0	0	0	1	0	0	0	10188	816	29	1	8073	1	NBEAL1	2	204078256	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1333457	204078256	39121117	87	5197										
CYP20A1	57404	broad.mit.edu	37	chr2	204154576	204154576	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagatattgaaggaaaaattGaccgatttattattcctaga	7	4	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204154576G>A	uc002uzv.3	+	10	1682	c.1060G>A	c.(1060-1062)GAC>AAC	p.D354N	CYP20A1_uc002uzx.3_Missense_Mutation_p.D252N|CYP20A1_uc010zif.1_Missense_Mutation_p.D362N|CYP20A1_uc002uzy.3_Missense_Mutation_p.D252N|CYP20A1_uc002uzw.3_RNA|CYP20A1_uc010ftw.2_Missense_Mutation_p.D84N	NM_177538	NP_803882	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A,	354						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0						AGGAAAAATTGACCGATTTAT	0.333													0	0	0	0.00874	0	42	23										A	204154576	G	A	204154576	3	1	19	1	0	0	0	0	1	0	0	0	4152	1290	45	1	1098	1	CYP20A1	2	204154576	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	76320	204154576	39044797	88	5198										
RAPH1	65059	broad.mit.edu	37	chr2	204304271	204304271	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgcctccgtaaccagccttCtgttgatcagacagcagttc	8	14	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204304271C>G	uc002vad.2	-	14	3867	c.3642G>C	c.(3640-3642)CAG>CAC	p.Q1214H		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	1214					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						AACCAGCCTTCTGTTGATCAG	0.562													0	0	0	0.001168	0	6	33										G	204304271	C	G	204304271	3	3	19	1	0	0	0	0	1	0	0	0	13050	912	32	1	114	1	RAPH1	2	204304271	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	149695	204304271	38895102	89	5199										
INO80D	54891	broad.mit.edu	37	chr2	206869295	206869295	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agaggtggaggccattagttCagcagaaggccccatgccac	13	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:206869295C>T	uc002vaz.3	-	11	3286	c.2881G>A	c.(2881-2883)GAA>AAA	p.E961K		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	Error:Variant_position_missing_in_Q53TQ3_after_alignment					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GCCATTAGTTCAGCAGAAGGC	0.597													0	0	0	0.010729	0	9	11										T	206869295	C	T	206869295	3	4	19	1	0	0	0	0	1	0	0	0	7749	835	29	1	206	1	INO80D	2	206869295	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2565024	206869295	36330078	90	5200										
ADAM23	8745	broad.mit.edu	37	chr2	207452091	207452091	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagacggatatgcatgcaatCaaaatcaggtatgctgggct	11	7	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:207452091C>G	uc002vbq.2	+	19	2003	c.1780C>G	c.(1780-1782)CAA>GAA	p.Q594E	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	594	Cys-rich.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGCATGCAATCAAAATCAGGT	0.289													0	0	0	0.013537	0	10	47										G	207452091	C	G	207452091	3	3	19	1	0	0	0	0	1	0	0	0	245	827	29	1	1854	1	ADAM23	2	207452091	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	582796	207452091	35747282	91	5201										
IDH1	3417	broad.mit.edu	37	chr2	209108167	209108167	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttacttgtcatatatctcctGaaagatgtctttaaaacgcc	5	9	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:209108167G>A	uc002vcs.2	-	6	928	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	IDH1_uc002vct.2_Nonsense_Mutation_p.Q228*|IDH1_uc002vcu.2_Nonsense_Mutation_p.Q228*	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	228					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TATATCTCCTGAAAGATGTCT	0.353			Mis		gliobastoma 								0	0	0	0.005443	0	25	39										A	209108167	G	A	209108167	4	1	19	1	0	0	0	0	0	1	0	0	7494	1299	45	1	582	1	IDH1	2	209108167	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1656076	209108167	34091206	92	5202										
CPS1	1373	broad.mit.edu	37	chr2	211513262	211513262	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttgaggccttcctatgttttGaggtaacactgtatattgtt	9	6	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:211513262G>A	uc002vee.3	+	27	3534	c.3402G>A	c.(3400-3402)TTG>TTA	p.L1134L	CPS1_uc010fur.2_Silent_p.L1140L|CPS1_uc010fus.2_Silent_p.L683L	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1134	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCTATGTTTTGAGGTAACACT	0.348													0	0	0	0.008291	0	9	73										A	211513262	G	A	211513262	2	1	19	1	0	0	0	0	0	0	0	1	3823	1281	45	1		1	CPS1	2	211513262	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2405095	211513262	31686111	93	5203										
FN1	2335	broad.mit.edu	37	chr2	216226285	216226285	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttggaaagatgatttactctCgggaatcttctctgtcagcc	9	9	4	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:216226285C>T	uc002vfa.2	-	46	7693	c.7427G>A	c.(7426-7428)CGA>CAA	p.R2476Q	FN1_uc002vfb.2_Missense_Mutation_p.R2264Q|FN1_uc002vfc.2_Missense_Mutation_p.R2239Q|FN1_uc002vfd.2_Missense_Mutation_p.R2420Q|FN1_uc002vfe.2_Missense_Mutation_p.R2354Q|FN1_uc002vff.2_Missense_Mutation_p.R2329Q|FN1_uc002vfg.2_Missense_Mutation_p.R2295Q|FN1_uc002vfh.2_Missense_Mutation_p.R2175Q|FN1_uc002vfi.2_Missense_Mutation_p.R2445Q|FN1_uc002vfj.2_Missense_Mutation_p.R2266Q|FN1_uc002vez.2_Missense_Mutation_p.R639Q|FN1_uc010zjp.1_Missense_Mutation_p.R1013Q	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2385					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATTTACTCTCGGGAATCTTC	0.408													0	0	0	0.008361	0	26	152										T	216226285	C	T	216226285	3	4	19	1	0	0	0	0	1	0	0	0	5962	884	31	1	10	1	FN1	2	216226285	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4713023	216226285	26973088	94	5204										
CHPF	79586	broad.mit.edu	37	chr2	220406623	220406638	+	Frame_Shift_Del	DEL	GGTGTCAGGCACCAGG	GGTGTCAGGCACCAGG	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccgtgcgcctcggtgtaggtGgtgtcaggcaccaggaagaa							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:220406623_220406638delGGTGTCAGGCACCAGG	uc002vmc.3	-	2	815_830	c.588_603delCCTGGTGCCTGACACC	c.(586-603)TTCCTGGTGCCTGACACCfs	p.F196fs	CHPF_uc010zlh.1_Frame_Shift_Del_p.F34fs|CHPF_uc002vmd.3_Frame_Shift_Del_p.F196fs|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	196_201	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CGGTGTAGGTGGTGTCAGGCACCAGGAAGAACCAGT	0.681											OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						7	19	---	---								-	220406638	GGTGTCAGGCACCAGG	-	220406623	7	5	19	1	0	1	0	1	0	0	0	0	3368	1335	47	0	1736	0	CHPF	2	220406623	Frame_Shift_Del	DEL	GGTGTCAGGCACCAGG	TCGA-BT-A3PJ-01A-21D-A21Z-08	4180338	220406623	22792750	95	5205										
DOCK10	55619	broad.mit.edu	37	chr2	225751218	225751218	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggtcaatctcaaaggaatgTgaaggaagcttctctggttt	11	6	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:225751218T>A	uc010fwz.1	-	5	686	c.447A>T	c.(445-447)TCA>TCT	p.S149S	DOCK10_uc002vob.2_Silent_p.S143S|DOCK10_uc002vod.1_Silent_p.S149S	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	149							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CAAAGGAATGTGAAGGAAGCT	0.333													0	0	0	0.010729	0	10	5										A	225751218	T	A	225751218	2	1	19	1	0	0	0	0	0	0	0	1	4685	1683	59	5		5	DOCK10	2	225751218	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	5344595	225751218	17448155	96	5206										
COL4A3	1285	broad.mit.edu	37	chr2	228157990	228157990	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggacatttggggcctgctggAcctgagggagcccctggaag	17	10	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:228157990A>T	uc002vom.1	+	38	3456	c.3294A>T	c.(3292-3294)GGA>GGT	p.G1098G	COL4A3_uc002von.1_Silent_p.G1098G|COL4A3_uc002voo.1_Silent_p.G1098G|COL4A3_uc002vop.1_Silent_p.G1098G|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1098	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCCTGCTGGACCTGAGGGAG	0.527													0	0	0	0.004672	0	3	29										T	228157990	A	T	228157990	2	4	19	1	0	0	0	0	0	0	0	1	3691	262	10	5		5	COL4A3	2	228157990	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2406772	228157990	15041383	97	5207										
RAMP1	10267	broad.mit.edu	37	chr2	238820246	238820246	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctggcccaatgcagaggtgGacaggttcttcctggcagtg	14	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:238820246G>T	uc002vxj.2	+	3	400	c.268G>T	c.(268-270)GAC>TAC	p.D90Y		NM_005855	NP_005846	O60894	RAMP1_HUMAN	receptor activity-modifying protein 1 precursor	90	Extracellular (Potential).				intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity				0		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	TGCAGAGGTGGACAGGTTCTT	0.642													1	0	4.01765e-15	0.009718	4.26278e-15	38	55										T	238820246	G	T	238820246	3	4	19	1	0	0	0	0	1	0	0	0	13021	1174	41	3	278	3	RAMP1	2	238820246	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	10662256	238820246	4379127	98	5208										
ASB1	51665	broad.mit.edu	37	chr2	239353166	239353166	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcaactgcaatggtcctgtCaacacacagggattctacag	8	11	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:239353166C>T	uc002vyg.2	+	4	764	c.678C>T	c.(676-678)GTC>GTT	p.V226V		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	226					intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		ATGGTCCTGTCAACACACAGG	0.597													0	0	0	0.00308	0	6	99										T	239353166	C	T	239353166	2	4	19	1	0	0	0	0	0	0	0	1	1013	813	29	1		1	ASB1	2	239353166	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	532920	239353166	3846207	99	5209										
GRM7	2917	broad.mit.edu	37	chr3	7348315	7348315	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagaaggggccatcaccattCagcccaagcgagccacggtg	12	14	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:7348315C>G	uc003bqm.2	+	4	1283	c.1009C>G	c.(1009-1011)CAG>GAG	p.Q337E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.Q337E|GRM7_uc003bql.2_Missense_Mutation_p.Q337E|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	337	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CATCACCATTCAGCCCAAGCG	0.507													0	0	0	0.008291	0	9	78										G	7348315	C	G	7348315	3	3	19	1	0	0	0	0	1	0	0	0	6802	827	29	1	1023	1	GRM7	3	7348315	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		7348315	190674115	100	5210										
FANCD2	2177	broad.mit.edu	37	chr3	10138051	10138051	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acccaacatgtgcctctgctCaaaaagaccctggaactttt	6	13	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:10138051C>G	uc003buw.2	+	42	4158	c.4080C>G	c.(4078-4080)CTC>CTG	p.L1360L	FANCD2_uc003bux.1_Silent_p.L1360L|FANCD2_uc003buy.1_Silent_p.L1360L|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1360					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGCCTCTGCTCAAAAAGACCC	0.423			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	48	58										G	10138051	C	G	10138051	2	3	19	1	0	0	0	0	0	0	0	1	5665	813	29	1		1	FANCD2	3	10138051	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2789736	10138051	187884379	101	5211										
RAF1	5894	broad.mit.edu	37	chr3	12653512	12653512	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gttgcaggcccctcaccttgAgtgctttcataaggcagtca	10	12	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:12653512A>C	uc003bxf.3	-	3	672	c.257T>G	c.(256-258)CTC>CGC	p.L86R	RAF1_uc011aut.1_5'Flank|RAF1_uc011auu.1_Intron	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	86	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	CCTCACCTTGAGTGCTTTCAT	0.488			T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				0	0	0	0.01441	0	47	172										C	12653512	A	C	12653512	3	2	19	1	0	0	0	0	1	0	0	0	13002	304	11	5	1749	5	RAF1	3	12653512	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2515461	12653512	185368918	102	5212										
FGD5	152273	broad.mit.edu	37	chr3	14941941	14941941	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aacctttgtccggactccgcCgagtacgacaacacacaggg	10	14	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:14941941C>G	uc003bzc.2	+	8	3296	c.3186C>G	c.(3184-3186)GCC>GCG	p.A1062A	FGD5_uc011avk.1_Silent_p.A1062A|FGD5_uc003bzd.2_Silent_p.A140A	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1062	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CGGACTCCGCCGAGTACGACA	0.577													0	0	0	0.008291	0	8	39										G	14941941	C	G	14941941	2	3	19	1	0	0	0	0	0	0	0	1	5836	639	23	4		4	FGD5	3	14941941	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2288429	14941941	183080489	103	5213										
ZNF385D	79750	broad.mit.edu	37	chr3	21466996	21466996	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgtttacctgtttaagttgCgtttccgagttgacgtgcac	10	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:21466996C>G	uc003cce.2	-	6	1248	c.840G>C	c.(838-840)ACG>ACC	p.T280T		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	280	Matrin-type 3.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GTTTAAGTTGCGTTTCCGAGT	0.413													0	0	0	0.013537	0	9	67										G	21466996	C	G	21466996	2	3	19	1	0	0	0	0	0	0	0	1	17875	755	27	4		4	ZNF385D	3	21466996	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6525055	21466996	176555434	104	5214										
NGLY1	55768	broad.mit.edu	37	chr3	25770771	25770771	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggtggagctgtttagaaatCttctcattttcacagggaat	10	6	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:25770771C>G	uc003cdl.2	-	10	1572	c.1464G>C	c.(1462-1464)AAG>AAC	p.K488N	NGLY1_uc010hfg.2_Missense_Mutation_p.K470N|NGLY1_uc003cdm.2_Missense_Mutation_p.K488N|NGLY1_uc011awo.1_Missense_Mutation_p.K446N|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	488	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						GTTTAGAAATCTTCTCATTTT	0.313													0	0	0	0.010729	0	11	13										G	25770771	C	G	25770771	3	3	19	1	0	0	0	0	1	0	0	0	10398	912	32	1	512	1	NGLY1	3	25770771	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4303775	25770771	172251659	105	5215										
DYNC1LI1	51143	broad.mit.edu	37	chr3	32578521	32578521	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acactgtaaacaaaacttccGgatatgtgactgaataaaat	6	7	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:32578521G>C	uc003cfb.3	-	6	902	c.814C>G	c.(814-816)CGG>GGG	p.R272G	DYNC1LI1_uc011axh.1_Missense_Mutation_p.R156G	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	272					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						CAAAACTTCCGGATATGTGAC	0.264													0	0	0	0.004656	0	23	46										C	32578521	G	C	32578521	3	2	19	1	0	0	0	0	1	0	0	0	4844	1115	39	4	789	4	DYNC1LI1	3	32578521	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	6807750	32578521	165443909	106	5216										
STAC	6769	broad.mit.edu	37	chr3	36422160	36422160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccctccgagcagcccccgcGaggacggcgtggacgggctg	16	16	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:36422160G>A	uc003cgh.1	+	1	64	c.25G>A	c.(25-27)GAG>AAG	p.E9K	STAC_uc010hgd.1_RNA|STAC_uc011aya.1_Missense_Mutation_p.E9K	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	9					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						CAGCCCCCGCGAGGACGGCGT	0.721													0	0	0	0.001168	0	3	22										A	36422160	G	A	36422160	3	1	19	1	0	0	0	0	1	0	0	0	15238	1059	37	1	27	1	STAC	3	36422160	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3843639	36422160	161600270	107	5217										
MAP4	4134	broad.mit.edu	37	chr3	47894824	47894824	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acccggacacagaggagcctCgctgccaccgccctcagtct	10	18	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:47894824C>T	uc003csb.2	-	18	3806	c.3280G>A	c.(3280-3282)GAG>AAG	p.E1094K	MAP4_uc003csc.3_Intron|MAP4_uc003crw.2_Missense_Mutation_p.E173K|MAP4_uc003crx.2_Missense_Mutation_p.E270K|MAP4_uc011bbe.1_Intron|MAP4_uc003cry.2_Missense_Mutation_p.E829K|MAP4_uc003csa.3_Missense_Mutation_p.E760K|MAP4_uc003crz.3_RNA	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	1094					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AGAGGAGCCTCGCTGCCACCG	0.652													0	0	0	0.000602	0	5	8										T	47894824	C	T	47894824	3	4	19	1	0	0	0	0	1	0	0	0	9258	893	31	1	337	1	MAP4	3	47894824	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	11472664	47894824	150127606	108	5218										
CCDC71	64925	broad.mit.edu	37	chr3	49201299	49201299	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tagcggcatgggaagcagtgTggcccgacctgcaggcaacc	15	12	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:49201299T>A	uc003cwg.3	-	2	481	c.343A>T	c.(343-345)ACA>TCA	p.T115S		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	115										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGAAGCAGTGTGGCCCGACCT	0.602													0	0	0	0.009718	0	43	64										A	49201299	T	A	49201299	3	1	19	1	0	0	0	0	1	0	0	0	2844	1696	59	5	1064	5	CCDC71	3	49201299	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1306475	49201299	148821131	109	5219										
MON1A	84315	broad.mit.edu	37	chr3	49949438	49949438	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgaacatggcaccctcctggCccgcacctgcaggccaaaag	10	17	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:49949438C>T	uc003cxz.2	-	3	551	c.425G>A	c.(424-426)GGC>GAC	p.G142D	MON1A_uc003cya.2_Intron|MON1A_uc003cyb.2_Intron	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	45							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ACCCTCCTGGCCCGCACCTGC	0.607													0	0	0	0.005443	0	21	74										T	49949438	C	T	49949438	3	4	19	1	0	0	0	0	1	0	0	0	9698	739	26	2	1549	2	MON1A	3	49949438	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	748139	49949438	148072992	110	5220										
IFRD2	7866	broad.mit.edu	37	chr3	50326727	50326727	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaagagcagtgcaatggtttCaccggcagcgatccgcaggt	13	10	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:50326727C>T	uc011bdp.1	-	8	1165	c.1036G>A	c.(1036-1038)GAA>AAA	p.E346K	IFRD2_uc003czb.2_Missense_Mutation_p.E448K	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	346							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCAATGGTTTCACCGGCAGCG	0.607													0	0	0	0.009096	0	4	10										T	50326727	C	T	50326727	3	4	19	1	0	0	0	0	1	0	0	0	7554	835	29	1	504	1	IFRD2	3	50326727	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	377289	50326727	147695703	111	5221										
RBM15B	29890	broad.mit.edu	37	chr3	51429743	51429743	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgtcccgggagcgggccctgGactactacgggctgtacgac	15	13	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:51429743G>A	uc003dbd.2	+	1	1013	c.913G>A	c.(913-915)GAC>AAC	p.D305N		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	305					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCGGGCCCTGGACTACTACGG	0.428													0	0	0	0.010504	0	18	30										A	51429743	G	A	51429743	3	1	19	1	0	0	0	0	1	0	0	0	13117	1174	41	1	915	1	RBM15B	3	51429743	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1103016	51429743	146592687	112	5222										
VPRBP	9730	broad.mit.edu	37	chr3	51458411	51458411	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgaatttcagcatcatggatGaagaactcaccctcagccac	7	12	4	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:51458411G>A	uc003dbe.1	-	14	2181	c.2013C>T	c.(2011-2013)TTC>TTT	p.F671F	VPRBP_uc003dbf.1_5'UTR	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	671					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CATCATGGATGAAGAACTCAC	0.363													0	0	0	0.008361	0	24	95										A	51458411	G	A	51458411	2	1	19	1	0	0	0	0	0	0	0	1	17182	1281	45	1		1	VPRBP	3	51458411	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	28668	51458411	146564019	113	5223										
APPL1	26060	broad.mit.edu	37	chr3	57282256	57282256	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggacagtgatatagagaccaTgcaacagacaatagaggatt	11	6	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:57282256T>C	uc003dio.2	+	10	887	c.740T>C	c.(739-741)ATG>ACG	p.M247T	APPL1_uc010hnb.2_Missense_Mutation_p.M247T|APPL1_uc011bey.1_Missense_Mutation_p.M230T	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	247	Required for RAB5A binding.|Potential.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		ATAGAGACCATGCAACAGACA	0.408													0	0	0	0.009535	0	25	88										C	57282256	T	C	57282256	3	2	19	1	0	0	0	0	1	0	0	0	817	1464	51	5	778	5	APPL1	3	57282256	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	5823845	57282256	140740174	114	5224										
PRICKLE2	166336	broad.mit.edu	37	chr3	64084988	64084988	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagcggtccccaaaggcattCtgcaaagccaggtccgacac	10	15	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:64084988C>T	uc003dmf.2	-	8	2860	c.2274G>A	c.(2272-2274)CAG>CAA	p.Q758Q		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	758						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CAAAGGCATTCTGCAAAGCCA	0.587													0	0	0	0.008291	0	10	41										T	64084988	C	T	64084988	2	4	19	1	0	0	0	0	0	0	0	1	12487	912	32	1		1	PRICKLE2	3	64084988	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6802732	64084988	133937442	115	5225										
LRIG1	26018	broad.mit.edu	37	chr3	66449393	66449393	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagggctggtgagatactcaCaggtgctccaggccttccag	13	12	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:66449393C>T	uc003dmx.2	-	10	1246	c.1232_splice	c.e10+1	p.L411_splice	LRIG1_uc011bfu.1_Splice_Site_p.L31_splice|LRIG1_uc003dmw.2_Splice_Site_p.L77_splice|LRIG1_uc010hnz.2_Intron|LRIG1_uc010hoa.2_Splice_Site_p.L435_splice	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like							integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GAGATACTCACAGGTGCTCCA	0.498													0	0	0	0.013537	0	9	25										T	66449393	C	T	66449393	5	4	19	1	0	0	0	0	0	0	1	0	8944	492	17	2	2088	2	LRIG1	3	66449393	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2364405	66449393	131573037	116	5226										
C3orf64	285203	broad.mit.edu	37	chr3	69027546	69027546	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtagtgaacgcctctcagccTggccaagtctaagtaacagc	10	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:69027546T>C	uc003dnl.2	-	17	1780	c.1375A>G	c.(1375-1377)AGG>GGG	p.R459G	C3orf64_uc003dnj.2_Missense_Mutation_p.R138G|C3orf64_uc003dnk.2_Missense_Mutation_p.R375G|C3orf64_uc011bfw.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	459						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		CCTCTCAGCCTGGCCAAGTCT	0.428													0	0	0	0.005443	0	24	100										C	69027546	T	C	69027546	3	2	19	1	0	0	0	0	1	0	0	0	2240	1579	55	5	216	5	C3orf64	3	69027546	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	2578153	69027546	128994884	117	5227										
PDZRN3	23024	broad.mit.edu	37	chr3	73432821	73432821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtagcgccccatcttcatctCgctcaccgcgtcgtcgtcgg	10	17	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:73432821C>T	uc003dpl.1	-	10	2992	c.2896G>A	c.(2896-2898)GAG>AAG	p.E966K	PDZRN3_uc011bgh.1_Missense_Mutation_p.E623K|PDZRN3_uc010hoe.1_Missense_Mutation_p.E664K|PDZRN3_uc011bgf.1_Missense_Mutation_p.E683K|PDZRN3_uc011bgg.1_Missense_Mutation_p.E686K	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	966							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		ATCTTCATCTCGCTCACCGCG	0.667													0	0	0	0.010818	0	27	138										T	73432821	C	T	73432821	3	4	19	1	0	0	0	0	1	0	0	0	11709	893	31	1	308	1	PDZRN3	3	73432821	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4405275	73432821	124589609	118	5228										
ROBO1	6091	broad.mit.edu	37	chr3	78649289	78649289	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcttcattattatcttctcCtctttcatatcctccaagta	1	12	6	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:78649289C>T	uc003dqe.2	-	30	5123	c.4915G>A	c.(4915-4917)GGA>AGA	p.G1639R	ROBO1_uc003dqb.2_Missense_Mutation_p.G1600R|ROBO1_uc003dqc.2_Missense_Mutation_p.G1539R|ROBO1_uc003dqd.2_Missense_Mutation_p.G1594R|ROBO1_uc010hoh.2_Missense_Mutation_p.G831R	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1639	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TTATCTTCTCCTCTTTCATAT	0.363													0	0	0	0.000602	0	3	17										T	78649289	C	T	78649289	3	4	19	1	0	0	0	0	1	0	0	0	13513	690	24	2	48	2	ROBO1	3	78649289	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5216468	78649289	119373141	119	5229										
CRYBG3	131544	broad.mit.edu	37	chr3	97618083	97618083	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggaggatcaaataatataatCatgtcgatacggccaatcca	8	8	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:97618083C>T	uc003drx.2	+	11	2167	c.2103C>T	c.(2101-2103)ATC>ATT	p.I701I		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						ATAATATAATCATGTCGATAC	0.363													0	0	0	0.01441	0	41	43										T	97618083	C	T	97618083	2	4	19	1	0	0	0	0	0	0	0	1	3913	816	29	1		1	CRYBG3	3	97618083	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	18968794	97618083	100404347	120	5230										
PVRL3	25945	broad.mit.edu	37	chr3	110830952	110830952	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaatgtttcattaaagtgttTaattgaagtaaatgaaacca	7	3	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:110830952T>C	uc003dxt.1	+	2	236	c.236T>C	c.(235-237)TTA>TCA	p.L79S	PVRL3_uc003dxu.1_Missense_Mutation_p.L56S	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	79	Extracellular (Potential).|Ig-like V-type.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						TTAAAGTGTTTAATTGAAGTA	0.388													0	0	0	0.010729	0	9	43										C	110830952	T	C	110830952	3	2	19	1	0	0	0	0	1	0	0	0	12841	1764	61	5	242	5	PVRL3	3	110830952	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	13212869	110830952	87191478	121	5231										
TMPRSS7	344805	broad.mit.edu	37	chr3	111794169	111794169	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgccctttctccaccaaagcCtgcagcaggagttcctccgc	8	17	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:111794169C>G	uc010hqb.2	+	13	1577	c.1407C>G	c.(1405-1407)ACC>ACG	p.T469T	TMPRSS7_uc011bhr.1_Silent_p.T324T	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	595	Extracellular (Potential).|LDL-receptor class A 3.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						CCACCAAAGCCTGCAGCAGGA	0.532													0	0	0	0.013726	0	32	131										G	111794169	C	G	111794169	2	3	19	1	0	0	0	0	0	0	0	1	16249	695	24	4		4	TMPRSS7	3	111794169	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	963217	111794169	86228261	122	5232										
KALRN	8997	broad.mit.edu	37	chr3	124438234	124438234	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cccgcctagcatgcttcataGaacgtcgcaagcaccagaat	8	14	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:124438234G>A	uc003ehg.2	+	60	9005	c.8878G>A	c.(8878-8880)GAA>AAA	p.E2960K	KALRN_uc003ehk.2_Missense_Mutation_p.E1263K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2959					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGCTTCATAGAACGTCGCAA	0.562													0	0	0	0.003954	0	25	105										A	124438234	G	A	124438234	3	1	19	1	0	0	0	0	1	0	0	0	7975	943	33	1	9272	1	KALRN	3	124438234	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	12644065	124438234	73584196	123	5233										
ALG1L	200810	broad.mit.edu	37	chr3	125652507	125652507	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	catccagctccatgaaggccGaccgctccatggctgcgtcc	10	17	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:125652507G>A	uc003eig.1	-	2	175	c.11C>T	c.(10-12)TCG>TTG	p.S4L		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	4							transferase activity, transferring glycosyl groups				0						CATGAAGGCCGACCGCTCCAT	0.637													0	0	0	0.00245	0	13	46										A	125652507	G	A	125652507	3	1	19	1	0	0	0	0	1	0	0	0	517	1059	37	1	572	1	ALG1L	3	125652507	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1214273	125652507	72369923	124	5234										
RUVBL1	8607	broad.mit.edu	37	chr3	127842556	127842556	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcgtagtgctcttcacctcCtcaatcttcattttgcagac	5	13	5	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:127842556C>G	uc003ekh.2	-	1	116	c.12G>C	c.(10-12)GAG>GAC	p.E4D	RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Missense_Mutation_p.E4D	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	4					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		TCTTCACCTCCTCAATCTTCA	0.612													0	0	0	0.014323	0	17	62										G	127842556	C	G	127842556	3	3	19	1	0	0	0	0	1	0	0	0	13752	680	24	4	1402	4	RUVBL1	3	127842556	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2190049	127842556	70179874	125	5235										
CPNE4	131034	broad.mit.edu	37	chr3	131415421	131415421	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccgtgcattgaatgcaagctCaacatagtcgtcattgccag	9	11	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:131415421C>G	uc003eok.2	-	5	907	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	CPNE4_uc011blq.1_Missense_Mutation_p.E176Q|CPNE4_uc003eol.2_Missense_Mutation_p.E176Q|CPNE4_uc003eom.2_Missense_Mutation_p.E158Q	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	158	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AATGCAAGCTCAACATAGTCG	0.408													0	0	0	0.01441	0	60	51										G	131415421	C	G	131415421	3	3	19	1	0	0	0	0	1	0	0	0	3814	835	29	1	1249	1	CPNE4	3	131415421	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3572865	131415421	66607009	126	5236										
DNAJC13	23317	broad.mit.edu	37	chr3	132211337	132211337	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtaacacaagagcactttatCagtattgccccattcctata	5	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:132211337C>T	uc003eor.2	+	33	3768	c.3703C>T	c.(3703-3705)CAG>TAG	p.Q1235*		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1235							heat shock protein binding			ovary(1)|breast(1)	2						AGCACTTTATCAGTATTGCCC	0.403													0	0	0	0.01441	0	147	176										T	132211337	C	T	132211337	4	4	19	1	0	0	0	0	0	1	0	0	4632	827	29	1	3829	1	DNAJC13	3	132211337	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	795916	132211337	65811093	127	5237										
C3orf36	80111	broad.mit.edu	37	chr3	133647173	133647173	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aattagttgccccgctctgcCttgagactgagactttctga	9	11	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:133647173C>G	uc003epz.1	-	1	1484	c.475G>C	c.(475-477)GGC>CGC	p.G159R		NM_025041	NP_079317	Q3SXR2	CC036_HUMAN	hypothetical protein LOC80111	159										ovary(1)	1						CCCGCTCTGCCTTGAGACTGA	0.517													0	0	0	0.006122	0	16	83										G	133647173	C	G	133647173	3	3	19	1	0	0	0	0	1	0	0	0	2226	681	24	4	26	4	C3orf36	3	133647173	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1435836	133647173	64375257	128	5238										
SLC25A36	55186	broad.mit.edu	37	chr3	140675471	140675471	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tatatttctgaagttcagctGaacaccatggctggagccag	10	9	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:140675471G>A	uc003etr.2	+	2	379	c.144G>A	c.(142-144)CTG>CTA	p.L48L	SLC25A36_uc003etp.2_Silent_p.L48L|SLC25A36_uc003ets.2_Silent_p.L48L|SLC25A36_uc003etq.2_5'UTR|SLC25A36_uc011bmz.1_Silent_p.L48L	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	48	Helical; Name=2; (Potential).|Solcar 1.				response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						AAGTTCAGCTGAACACCATGG	0.453													0	0	0	0.00333	0	22	133										A	140675471	G	A	140675471	2	1	19	1	0	0	0	0	0	0	0	1	14500	1277	45	1		1	SLC25A36	3	140675471	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7028298	140675471	57346959	129	5239										
PPM1L	151742	broad.mit.edu	37	chr3	160474178	160474178	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgagacccgagacgcttttcCtgctgtgcatcagcttggct	11	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:160474178C>T	uc003fdr.2	+	1	183	c.82C>T	c.(82-84)CTG>TTG	p.L28L		NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	28	Helical; (Potential).				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			GACGCTTTTCCTGCTGTGCAT	0.522													0	0	0	0.003163	0	15	89										T	160474178	C	T	160474178	2	4	19	1	0	0	0	0	0	0	0	1	12344	680	24	2		2	PPM1L	3	160474178	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	19798707	160474178	37548252	130	5240										
WDR49	151790	broad.mit.edu	37	chr3	167277882	167277882	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccatctgtgctgccagtcaaAagccgagtctcatttgcatc	8	13	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:167277882A>G	uc003fev.1	-	5	927	c.621T>C	c.(619-621)CTT>CTC	p.L207L	WDR49_uc003feu.1_Silent_p.L32L|WDR49_uc011bpd.1_Silent_p.L260L|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	207	WD 4.									large_intestine(1)|ovary(1)|skin(1)	3						TGCCAGTCAAAAGCCGAGTCT	0.453													0	0	0	0.010818	0	25	150										G	167277882	A	G	167277882	2	3	19	1	0	0	0	0	0	0	0	1	17299	1	1	5		5	WDR49	3	167277882	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	6803704	167277882	30744548	131	5241										
SLC7A14	57709	broad.mit.edu	37	chr3	170198742	170198742	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttggtgtgctcctcagacaaGaacttgacaaaaccatcaat	7	10	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:170198742G>A	uc003fgz.2	-	7	1645	c.1329C>T	c.(1327-1329)TTC>TTT	p.F443F	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	443						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CCTCAGACAAGAACTTGACAA	0.512													0	0	0	0.01441	0	49	55										A	170198742	G	A	170198742	2	1	19	1	0	0	0	0	0	0	0	1	14696	933	33	1		1	SLC7A14	3	170198742	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2920860	170198742	27823688	132	5242										
CCDC39	339829	broad.mit.edu	37	chr3	180397147	180397147	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cccatcctcccagtgcagctCagccaggaattcgctactca	7	17	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:180397147C>T	uc010hxe.2	-	1	137	c.22G>A	c.(22-24)GAG>AAG	p.E8K	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	8					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAGTGCAGCTCAGCCAGGAAT	0.557													0	0	0	0.01441	0	140	194										T	180397147	C	T	180397147	3	4	19	1	0	0	0	0	1	0	0	0	2811	835	29	1	2883	1	CCDC39	3	180397147	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	10198405	180397147	17625283	133	5243										
YEATS2	55689	broad.mit.edu	37	chr3	183432930	183432930	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttaatttatcattgcttcacAgtgaagaactgaatgtcatc	6	7	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:183432930A>T	uc003fly.2	+	2	177	c.-18_splice	c.e2-2			NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATTGCTTCACAGTGAAGAACT	0.358													0	0	0	0.007835	0	40	39										T	183432930	A	T	183432930	5	4	19	1	0	0	0	0	0	0	1	0	17469	202	7	5		5	YEATS2	3	183432930	Splice_Site	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	3035783	183432930	14589500	134	5244										
C3orf21	152002	broad.mit.edu	37	chr3	194790762	194790762	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcaacatcaccccgctgttGaagcccggcagcccctcggg	11	17	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:194790762G>A	uc003fum.3	-	4	972	c.864C>T	c.(862-864)TTC>TTT	p.F288F	C3orf21_uc003ful.2_Silent_p.F85F|C3orf21_uc003fuk.2_Silent_p.F82F	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	288						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		CCCCGCTGTTGAAGCCCGGCA	0.677													0	0	0	0.004878	0	28	131										A	194790762	G	A	194790762	2	1	19	1	0	0	0	0	0	0	0	1	2214	1281	45	1		1	C3orf21	3	194790762	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	11357832	194790762	3231668	135	5245										
GAK	2580	broad.mit.edu	37	chr4	875739	875739	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtgggcagcgcttcatgctGaacatgtacacggcggcctc	14	12	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:875739G>A	uc003gbm.3	-	15	1816	c.1617C>T	c.(1615-1617)TTC>TTT	p.F539F	GAK_uc003gbn.3_Silent_p.F460F|GAK_uc010ibk.1_Silent_p.F433F|GAK_uc003gbl.3_Silent_p.F403F	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	539	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GCTTCATGCTGAACATGTACA	0.652													0	0	0	0.00499	0	14	10										A	875739	G	A	875739	2	1	19	1	0	0	0	0	0	0	0	1	6195	1281	45	1		1	GAK	4	875739	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		875739	190278537	136	5246										
GAK	2580	broad.mit.edu	37	chr4	875769	875769	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acggcggcctccgcggtgctGaagagacggcagaagcacag	16	12	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:875769G>C	uc003gbm.3	-	15	1786	c.1587C>G	c.(1585-1587)TTC>TTG	p.F529L	GAK_uc003gbn.3_Missense_Mutation_p.F450L|GAK_uc010ibk.1_Missense_Mutation_p.F423L|GAK_uc003gbl.3_Missense_Mutation_p.F393L	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	529	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CCGCGGTGCTGAAGAGACGGC	0.642													0	0	0	0.004007	0	12	8										C	875769	G	C	875769	3	2	19	1	0	0	0	0	1	0	0	0	6195	1281	45	1	2404	1	GAK	4	875769	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	30	875769	190278507	137	5247										
KIAA1530	57654	broad.mit.edu	37	chr4	1377693	1377693	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgaaggctcaggctgatacCgcccgcgctcgcattgggag	14	13	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:1377693C>T	uc003gde.3	+	13	2448	c.2001C>T	c.(1999-2001)ACC>ACT	p.T667T	KIAA1530_uc010ibv.2_Silent_p.T218T	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	667											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			AGGCTGATACCGCCCGCGCTC	0.642													0	0	0	0.004007	0	14	67										T	1377693	C	T	1377693	2	4	19	1	0	0	0	0	0	0	0	1	8241	639	23	2		2	KIAA1530	4	1377693	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	501924	1377693	189776583	138	5248										
MFSD10	10227	broad.mit.edu	37	chr4	2935298	2935298	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acagagccagccatacctccGaacaggacactgttgtacct	8	14	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:2935298G>A	uc003gfw.2	-	2	578	c.264C>T	c.(262-264)TTC>TTT	p.F88F	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_5'UTR|MFSD10_uc003gfz.2_Silent_p.F88F|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Silent_p.F88F|MFSD10_uc003ggb.1_Silent_p.F88F|MFSD10_uc003ggc.2_Silent_p.F88F|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank|C4orf10_uc003ggg.1_5'Flank|C4orf10_uc003ggh.2_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	88	Helical; (Potential).				apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCATACCTCCGAACAGGACAC	0.632													0	0	0	0.004007	0	15	50										A	2935298	G	A	2935298	2	1	19	1	0	0	0	0	0	0	0	1	9528	1049	37	1		1	MFSD10	4	2935298	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1557605	2935298	188218978	139	5249										
JAKMIP1	152789	broad.mit.edu	37	chr4	6107652	6107652	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccgtcgctgctcctgctcgcGctccagcttcgcctcctgca	9	20	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:6107652G>A	uc003giu.3	-	3	448	c.172C>T	c.(172-174)CGC>TGC	p.R58C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R58C|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.R58C|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.R58C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R58C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	58	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCCTGCTCGCGCTCCAGCTTC	0.562													0	0	0	0.003755	0	26	45										A	6107652	G	A	6107652	3	1	19	1	0	0	0	0	1	0	0	0	7940	1087	38	2	2474	2	JAKMIP1	4	6107652	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3172354	6107652	185046624	140	5250										
SLAIN2	57606	broad.mit.edu	37	chr4	48422313	48422313	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tatggttcagagcacagtctCagcaaatcctcccagcaata	7	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:48422313C>T	uc003gya.3	+	7	1676	c.1532C>T	c.(1531-1533)TCA>TTA	p.S511L		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	511						centrosome					0						AGCACAGTCTCAGCAAATCCT	0.522													0	0	0	0.01441	0	57	103										T	48422313	C	T	48422313	3	4	19	1	0	0	0	0	1	0	0	0	14366	838	29	1	1558	1	SLAIN2	4	48422313	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	42314661	48422313	142731963	141	5251										
FRYL	285527	broad.mit.edu	37	chr4	48553580	48553580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgggagctaccattgtattgCtactggaagtagttcctgta	11	7	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:48553580C>T	uc003gyh.1	-	37	5056	c.4451G>A	c.(4450-4452)AGC>AAC	p.S1484N	FRYL_uc003gyk.2_Missense_Mutation_p.S1484N|FRYL_uc003gyg.1_Missense_Mutation_p.S180N|FRYL_uc003gyi.1_Missense_Mutation_p.S373N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1484					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CATTGTATTGCTACTGGAAGT	0.358													0	0	0	0.008291	0	10	58										T	48553580	C	T	48553580	3	4	19	1	0	0	0	0	1	0	0	0	6064	797	28	2	4702	2	FRYL	4	48553580	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	131267	48553580	142600696	142	5252										
KIT	3815	broad.mit.edu	37	chr4	55524222	55524222	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgggattttctctgcgttcTgctcctactgcttcgcgtcc	9	14	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:55524222T>G	uc010igr.2	+	1	128	c.41T>G	c.(40-42)CTG>CGG	p.L14R	KIT_uc010igs.2_Missense_Mutation_p.L14R	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	14					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTCTGCGTTCTGCTCCTACTG	0.667		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	0.004656	0	24	31										G	55524222	T	G	55524222	3	3	19	1	0	0	0	0	1	0	0	0	8329	1580	55	5	43	5	KIT	4	55524222	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	6970642	55524222	135630054	143	5253										
PPAT	5471	broad.mit.edu	37	chr4	57266984	57266984	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caagagcagcaggcgtagcaGattctggaacagtgctaacc	12	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:57266984G>C	uc003hbr.2	-	8	1182	c.980C>G	c.(979-981)TCT>TGT	p.S327C		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	327		Magnesium (By similarity).			glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	AGGCGTAGCAGATTCTGGAAC	0.458													0	0	0	0.004878	0	36	121										C	57266984	G	C	57266984	3	2	19	1	0	0	0	0	1	0	0	0	12302	942	33	1	589	1	PPAT	4	57266984	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1742762	57266984	133887292	144	5254										
UGT2A1	10941	broad.mit.edu	37	chr4	70513304	70513304	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gccaaatcaaaacattcccaCcaagagtggttcctatgaga	7	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:70513304C>A	uc003hem.3	-	1	122	c.59G>T	c.(58-60)GGT>GTT	p.G20V	UGT2A1_uc011caq.1_Missense_Mutation_p.G20V|UGT2A1_uc010ihu.2_Missense_Mutation_p.G20V|UGT2A1_uc010iht.2_Missense_Mutation_p.G20V	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	20					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						AACATTCCCACCAAGAGTGGT	0.383													1	0	0.00448238	0.004482	0.00455262	7	12										A	70513304	C	A	70513304	3	1	19	1	0	0	0	0	1	0	0	0	16950	507	18	4	1548	4	UGT2A1	4	70513304	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	13246320	70513304	120640972	145	5255										
CDKL2	8999	broad.mit.edu	37	chr4	76529105	76529105	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccagcaaacacaggattttTattaaaaagctcctgatgcc	6	10	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:76529105T>C	uc003hiq.2	-	6	1216	c.691A>G	c.(691-693)AAA>GAA	p.K231E	CDKL2_uc011cbp.1_Missense_Mutation_p.K231E|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	231	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACAGGATTTTTATTAAAAAGC	0.388													0	0	0	0.010729	0	10	49										C	76529105	T	C	76529105	3	2	19	1	0	0	0	0	1	0	0	0	3154	1763	61	5	814	5	CDKL2	4	76529105	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	6015801	76529105	114625171	146	5256										
STBD1	8987	broad.mit.edu	37	chr4	77230498	77230498	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taggagttactctgaagtttCaagaaatgaaagccttgaat	9	5	2	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:77230498C>T	uc003hka.2	+	2	668	c.422C>T	c.(421-423)TCA>TTA	p.S141L	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_5'UTR	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	141	Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			TCTGAAGTTTCAAGAAATGAA	0.428													0	0	0	0.00308	0	7	32										T	77230498	C	T	77230498	3	4	19	1	0	0	0	0	1	0	0	0	15273	838	29	1	428	1	STBD1	4	77230498	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	701393	77230498	113923778	147	5257										
FRAS1	80144	broad.mit.edu	37	chr4	79295384	79295384	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggaaggggtactttgcagatCatgcaaagcacaaatgcaca	11	8	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:79295384C>T	uc003hlb.2	+	25	3570	c.3130C>T	c.(3130-3132)CAT>TAT	p.H1044Y	FRAS1_uc003hkw.2_Missense_Mutation_p.H1044Y	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1043	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTTTGCAGATCATGCAAAGCA	0.507													0	0	0	0.00623	0	28	111										T	79295384	C	T	79295384	3	4	19	1	0	0	0	0	1	0	0	0	6042	826	29	1	3228	1	FRAS1	4	79295384	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2064886	79295384	111858892	148	5258										
SEC31A	22872	broad.mit.edu	37	chr4	83740266	83740266	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctgggtgagaacaactttGagaactggcatgaaagcaga	13	7	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:83740266G>C	uc003hnf.2	-	27	3788	c.3624C>G	c.(3622-3624)CTC>CTG	p.L1208L	SEC31A_uc003hnd.2_Silent_p.L377L|SEC31A_uc003hne.2_Silent_p.L957L|SEC31A_uc011ccl.1_Silent_p.L1154L|SEC31A_uc003hnl.2_Silent_p.L1055L|SEC31A_uc003hng.2_Silent_p.L1193L|SEC31A_uc003hnh.2_Silent_p.L1208L|SEC31A_uc003hni.2_Silent_p.L1094L|SEC31A_uc003hnj.2_Silent_p.L1169L|SEC31A_uc011ccm.1_Silent_p.L1188L|SEC31A_uc011ccn.1_Silent_p.L1193L|SEC31A_uc003hnk.2_Silent_p.L1169L|SEC31A_uc003hnm.2_Silent_p.L1208L	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1208					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GAACAACTTTGAGAACTGGCA	0.418													0	0	0	0.006122	0	17	30										C	83740266	G	C	83740266	2	2	19	1	0	0	0	0	0	0	0	1	13998	1277	45	1		1	SEC31A	4	83740266	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4444882	83740266	107414010	149	5259										
COL25A1	84570	broad.mit.edu	37	chr4	109790268	109790268	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gttcctggtaaacctggtaaGcctggttctccttgaggacc	11	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:109790268G>A	uc003hze.1	-	19	1590	c.1059C>T	c.(1057-1059)GGC>GGT	p.G353G	COL25A1_uc003hzg.2_Silent_p.G353G|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Silent_p.G134G	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	353	Extracellular (Potential).|Collagen-like 4.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		AACCTGGTAAGCCTGGTTCTC	0.244													0	0	0	0.001984	0	6	33										A	109790268	G	A	109790268	2	1	19	1	0	0	0	0	0	0	0	1	3684	958	34	2		2	COL25A1	4	109790268	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	26050002	109790268	81364008	150	5260										
TIFA	92610	broad.mit.edu	37	chr4	113199085	113199085	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcagagcgaataagtgccaTactccggtatgggcctgtgt	13	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:113199085T>C	uc003ial.2	-	2	770	c.488A>G	c.(487-489)TAT>TGT	p.Y163C		NM_052864	NP_443096	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with a	163							protein binding			breast(1)	1		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ATAAGTGCCATACTCCGGTAT	0.428													0	0	0	0.004482	0	9	28										C	113199085	T	C	113199085	3	2	19	1	0	0	0	0	1	0	0	0	15891	1406	49	5	70	5	TIFA	4	113199085	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	3408817	113199085	77955191	151	5261										
ANK2	287	broad.mit.edu	37	chr4	114158209	114158209	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggcggtggccatcctcttgGagaatgacaccaaagggaaa	13	9	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:114158209G>C	uc003ibe.3	+	6	650	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	ANK2_uc003ibd.3_Missense_Mutation_p.E163Q|ANK2_uc003ibf.3_Missense_Mutation_p.E184Q|ANK2_uc003ibc.2_Missense_Mutation_p.E160Q|ANK2_uc011cgb.1_Missense_Mutation_p.E199Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	184	ANK 5.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CATCCTCTTGGAGAATGACAC	0.498													0	0	0	0.01441	0	44	176										C	114158209	G	C	114158209	3	2	19	1	0	0	0	0	1	0	0	0	621	1175	41	1	597	1	ANK2	4	114158209	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	959124	114158209	76996067	152	5262										
FAT4	79633	broad.mit.edu	37	chr4	126412206	126412206	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acctgccaacctggcattttCaactatgccacaaggctggg	9	13	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:126412206C>A	uc003ifj.3	+	17	14229	c.14229C>A	c.(14227-14229)TTC>TTA	p.F4743L	FAT4_uc011cgp.1_Missense_Mutation_p.F2984L|FAT4_uc003ifi.1_Missense_Mutation_p.F2220L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4743	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGCATTTTCAACTATGCCA	0.498													1	0	3.27435e-08	0.00245	3.39827e-08	13	69										A	126412206	C	A	126412206	3	1	19	1	0	0	0	0	1	0	0	0	5692	825	29	3	14295	3	FAT4	4	126412206	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	12253997	126412206	64742070	153	5263										
PLK4	10733	broad.mit.edu	37	chr4	128804637	128804637	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caattatgtgtatctggtatTagaaatgtgccataatggag	10	4	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:128804637T>C	uc003ifo.2	+	4	511	c.266T>C	c.(265-267)TTA>TCA	p.L89S	PLK4_uc011cgs.1_Missense_Mutation_p.L57S|PLK4_uc011cgt.1_Missense_Mutation_p.L48S	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	89	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TATCTGGTATTAGAAATGTGC	0.308													0	0	0	0.014323	0	18	27										C	128804637	T	C	128804637	3	2	19	1	0	0	0	0	1	0	0	0	12098	1764	61	5	280	5	PLK4	4	128804637	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	2392431	128804637	62349639	154	5264										
ARFIP1	27236	broad.mit.edu	37	chr4	153831239	153831239	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaagtattgcacaatcagctGgtccttttccacaatgccat	6	11	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:153831239G>T	uc003imz.2	+	9	1266	c.990G>T	c.(988-990)CTG>CTT	p.L330L	ARFIP1_uc003inb.2_Silent_p.L298L|ARFIP1_uc003ina.2_Silent_p.L298L|ARFIP1_uc003inc.2_Silent_p.L330L|ARFIP1_uc011cij.1_Silent_p.L150L	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	330	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					ACAATCAGCTGGTCCTTTTCC	0.403													1	0	1.4051e-37	0.01441	1.53186e-37	68	104										T	153831239	G	T	153831239	2	4	19	1	0	0	0	0	0	0	0	1	854	1335	47	4		4	ARFIP1	4	153831239	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	25026602	153831239	37323037	155	5265										
KIAA0922	23240	broad.mit.edu	37	chr4	154506049	154506049	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaacaacacacactccaacaCtaaaagcatgcctcttctct	2	15	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:154506049C>T	uc003inm.3	+	12	1172	c.1120C>T	c.(1120-1122)CTA>TTA	p.L374L	KIAA0922_uc010ipp.2_Silent_p.L375L|KIAA0922_uc010ipq.2_Silent_p.L227L|KIAA0922_uc010ips.1_5'UTR	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	374	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CACTCCAACACTAAAAGCATG	0.393													0	0	0	0.010818	0	25	43										T	154506049	C	T	154506049	2	4	19	1	0	0	0	0	0	0	0	1	8201	564	20	2		2	KIAA0922	4	154506049	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	674810	154506049	36648227	156	5266										
RNF175	285533	broad.mit.edu	37	chr4	154669807	154669807	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gatgactcacattgtaggatCggccatgcctctgtctccac	9	13	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:154669807C>G	uc003int.2	-	3	609	c.236G>C	c.(235-237)CGA>CCA	p.R79P	RNF175_uc003inu.1_Missense_Mutation_p.D3H	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	79						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				ATTGTAGGATCGGCCATGCCT	0.532													0	0	0	0.000602	0	4	16										G	154669807	C	G	154669807	3	3	19	1	0	0	0	0	1	0	0	0	13463	884	31	1	778	1	RNF175	4	154669807	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	163758	154669807	36484469	157	5267										
DCHS2	54798	broad.mit.edu	37	chr4	155158295	155158295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccagaagtaatacgggactGatagtaaatattgtgcctga	10	6	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:155158295G>C	uc003inw.2	-	25	6144	c.6144C>G	c.(6142-6144)ATC>ATG	p.I2048M		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2048	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATACGGGACTGATAGTAAATA	0.383													0	0	0	0.00499	0	14	17										C	155158295	G	C	155158295	3	2	19	1	0	0	0	0	1	0	0	0	4288	1280	45	1	2610	1	DCHS2	4	155158295	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	488488	155158295	35995981	158	5268										
FGG	2266	broad.mit.edu	37	chr4	155533181	155533181	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttttctcacttggttttgatGattcatcaggattataagtg	8	5	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:155533181G>A	uc003ioj.2	-	3	437	c.296C>T	c.(295-297)TCA>TTA	p.S99L	FGG_uc003iog.2_Missense_Mutation_p.S99L|FGG_uc003ioh.2_Missense_Mutation_p.S99L|FGG_uc010ipx.2_5'UTR|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'Flank|FGG_uc003iok.2_Missense_Mutation_p.S99L	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	99					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGGTTTTGATGATTCATCAGG	0.308													0	0	0	0.000602	0	4	21										A	155533181	G	A	155533181	3	1	19	1	0	0	0	0	1	0	0	0	5870	1294	45	1	1112	1	FGG	4	155533181	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	374886	155533181	35621095	159	5269										
GUCY1B3	2983	broad.mit.edu	37	chr4	156723650	156723650	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcatctggagaaggagccatGaagatcgtcaacctcctcaa	10	11	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:156723650G>A	uc003ipc.2	+	10	1499	c.1332G>A	c.(1330-1332)ATG>ATA	p.M444I	GUCY1B3_uc011cio.1_Missense_Mutation_p.M466I|GUCY1B3_uc011cip.1_Missense_Mutation_p.M424I|GUCY1B3_uc003ipd.2_Missense_Mutation_p.M372I|GUCY1B3_uc010iqf.2_Missense_Mutation_p.M411I|GUCY1B3_uc010iqg.2_Missense_Mutation_p.M415I|GUCY1B3_uc011ciq.1_Missense_Mutation_p.M372I	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	444	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAGGAGCCATGAAGATCGTCA	0.453													0	0	0	0.004672	0	3	25										A	156723650	G	A	156723650	3	1	19	1	0	0	0	0	1	0	0	0	6895	1290	45	1	1370	1	GUCY1B3	4	156723650	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1190469	156723650	34430626	160	5270										
DDX60L	91351	broad.mit.edu	37	chr4	169374324	169374324	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccaagagcatgtgatgactCgagaacaagctctctgagaa	10	9	1	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:169374324C>G	uc003irq.3	-	8	1168	c.947G>C	c.(946-948)CGA>CCA	p.R316P	DDX60L_uc003irr.1_Missense_Mutation_p.R316P|DDX60L_uc003irs.1_Missense_Mutation_p.R43P	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	316							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TGTGATGACTCGAGAACAAGC	0.408													0	0	0	0.006999	0	35	39										G	169374324	C	G	169374324	3	3	19	1	0	0	0	0	1	0	0	0	4379	884	31	1	4297	1	DDX60L	4	169374324	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	12650674	169374324	21779952	161	5271										
C4orf41	60684	broad.mit.edu	37	chr4	184607795	184607795	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtgcaaagccaagtttcatgCcccaagttttcatgttgatg	9	9	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:184607795C>T	uc003ivx.2	+	18	1963	c.1787C>T	c.(1786-1788)GCC>GTC	p.A596V	C4orf41_uc003ivw.2_Missense_Mutation_p.A596V|C4orf41_uc010isc.2_Intron|C4orf41_uc003ivy.2_Missense_Mutation_p.A202V	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	596											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		AAGTTTCATGCCCCAAGTTTT	0.413													0	0	0	0.01441	0	75	151										T	184607795	C	T	184607795	3	4	19	1	0	0	0	0	1	0	0	0	2270	739	26	2	1853	2	C4orf41	4	184607795	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	15233471	184607795	6546481	162	5272										
F11	2160	broad.mit.edu	37	chr4	187206844	187206844	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtggcattttaaatcaatctGaaataaaagaggacacatct	7	6	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:187206844G>C	uc003iza.1	+	12	1690	c.1357G>C	c.(1357-1359)GAA>CAA	p.E453Q		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	453	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AAATCAATCTGAAATAAAAGA	0.348													0	0	0	0.001855	0	10	44										C	187206844	G	C	187206844	3	2	19	1	0	0	0	0	1	0	0	0	5337	1291	45	1	1399	1	F11	4	187206844	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2599049	187206844	3947432	163	5273										
ZFP42	132625	broad.mit.edu	37	chr4	188924151	188924151	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcctggccctcaggctctcGgaggggatgatttctcagac	13	12	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:188924151G>C	uc003izg.1	+	3	435	c.190G>C	c.(190-192)GGA>CGA	p.G64R	ZFP42_uc003izh.1_Missense_Mutation_p.G64R|ZFP42_uc003izi.1_Missense_Mutation_p.G64R	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	64					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCAGGCTCTCGGAGGGGATGA	0.507													0	0	0	0.00308	0	6	47										C	188924151	G	C	188924151	3	2	19	1	0	0	0	0	1	0	0	0	17647	1117	39	4	192	4	ZFP42	4	188924151	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1717307	188924151	2230125	164	5274										
LRRC14B	389257	broad.mit.edu	37	chr5	195402	195402	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acaagcaatgagcttggtgcTttcttgctgcaagctttcaa	9	9	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:195402T>G	uc003jal.1	+	2	1507	c.1479T>G	c.(1477-1479)GCT>GCG	p.A493A		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	493										skin(1)	1						AGCTTGGTGCTTTCTTGCTGC	0.483													0	0	0	0.001855	0	14	123										G	195402	T	G	195402	2	3	19	1	0	0	0	0	0	0	0	1	8969	1596	56	5		5	LRRC14B	5	195402	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08		195402	180719858	165	5275										
KIAA0947	23379	broad.mit.edu	37	chr5	5464730	5464730	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgtatccagagttatctgcCagggcccggaccctcaacat	9	13	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:5464730C>T	uc003jdm.3	+	13	5505	c.5283C>T	c.(5281-5283)GCC>GCT	p.A1761A		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1761										ovary(1)|central_nervous_system(1)	2						AGTTATCTGCCAGGGCCCGGA	0.547													0	0	0	0.006122	0	16	20										T	5464730	C	T	5464730	2	4	19	1	0	0	0	0	0	0	0	1	8202	581	21	2		2	KIAA0947	5	5464730	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5269328	5464730	175450530	166	5276										
TARS	6897	broad.mit.edu	37	chr5	33459811	33459811	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttctatcagagcgaatatagGaaaagaggattccaggaggt	12	5	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:33459811G>A	uc003jhy.2	+	11	1390	c.1095G>A	c.(1093-1095)AGG>AGA	p.R365R	TARS_uc011cob.1_Silent_p.R353R|TARS_uc010iup.1_Silent_p.R306R|TARS_uc011coc.1_Silent_p.R386R|TARS_uc003jhz.2_Silent_p.R261R|TARS_uc011cod.1_Silent_p.R244R	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	365					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	GCGAATATAGGAAAAGAGGAT	0.398													0	0	0	0.01441	0	69	57										A	33459811	G	A	33459811	2	1	19	1	0	0	0	0	0	0	0	1	15556	1165	41	1		1	TARS	5	33459811	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	27995081	33459811	147455449	167	5277										
NUP155	9631	broad.mit.edu	37	chr5	37324164	37324164	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcctgcaaaccctttagttCttgtagcactgactctagca	6	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:37324164C>G	uc003jku.1	-	20	2255	c.2137G>C	c.(2137-2139)GAA>CAA	p.E713Q	NUP155_uc003jkt.1_Missense_Mutation_p.E654Q|NUP155_uc010iuz.1_Missense_Mutation_p.E713Q	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	713					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCCTTTAGTTCTTGTAGCACT	0.358													0	0	0	0.01441	0	54	59										G	37324164	C	G	37324164	3	3	19	1	0	0	0	0	1	0	0	0	10756	922	32	1	2102	1	NUP155	5	37324164	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3864353	37324164	143591096	168	5278										
EGFLAM	133584	broad.mit.edu	37	chr5	38418241	38418241	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagcgcttactggttggttaGagcaacagggacaaaccgag	13	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:38418241G>C	uc003jlc.1	+	12	1892	c.1568G>C	c.(1567-1569)AGA>ACA	p.R523T	EGFLAM_uc003jlb.1_Missense_Mutation_p.R523T|EGFLAM_uc003jle.1_Missense_Mutation_p.R289T|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	523	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TGGTTGGTTAGAGCAACAGGG	0.512													0	0	0	0.005443	0	26	172										C	38418241	G	C	38418241	3	2	19	1	0	0	0	0	1	0	0	0	4966	942	33	1	1628	1	EGFLAM	5	38418241	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1094077	38418241	142497019	169	5279										
OSMR	9180	broad.mit.edu	37	chr5	38869153	38869153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaaaaccagaactgatggctCtatttgcagtctttcagaca	8	9	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:38869153C>G	uc003jln.1	+	2	374	c.7C>G	c.(7-9)CTA>GTA	p.L3V	OSMR_uc003jlm.1_Missense_Mutation_p.L3V	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	3					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACTGATGGCTCTATTTGCAGT	0.318													0	0	0	0.01441	0	67	57										G	38869153	C	G	38869153	3	3	19	1	0	0	0	0	1	0	0	0	11292	912	32	1	9	1	OSMR	5	38869153	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	450912	38869153	142046107	170	5280										
HCN1	348980	broad.mit.edu	37	chr5	45353208	45353208	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acaataaatcttacctctctCagaggatcattgagttcatt	5	9	5	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:45353208C>G	uc003jok.2	-	5	1396	c.1371G>C	c.(1369-1371)CTG>CTC	p.L457L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	457	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTACCTCTCTCAGAGGATCAT	0.343													0	0	0	0.004482	0	7	71										G	45353208	C	G	45353208	2	3	19	1	0	0	0	0	0	0	0	1	6996	813	29	1		1	HCN1	5	45353208	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6484055	45353208	135562052	171	5281										
IPO11	51194	broad.mit.edu	37	chr5	61733234	61733234	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacacagccaggtttctattCagtgttgctggtaagttgtt	11	7	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:61733234C>T	uc003jtc.2	+	2	318	c.128C>T	c.(127-129)TCA>TTA	p.S43L	IPO11_uc011cqr.1_Missense_Mutation_p.S83L|IPO11_uc003jtb.1_Missense_Mutation_p.S43L	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	43	Importin N-terminal.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		GGTTTCTATTCAGTGTTGCTG	0.378													0	0	0	0.010504	0	19	25										T	61733234	C	T	61733234	3	4	19	1	0	0	0	0	1	0	0	0	7793	838	29	1	254	1	IPO11	5	61733234	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	16380026	61733234	119182026	172	5282										
POLK	51426	broad.mit.edu	37	chr5	74892219	74892219	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgtctcataagaagagtttCtttgataaaaaacgatcaga	7	5	3	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:74892219C>G	uc003kdw.2	+	13	1797	c.1701C>G	c.(1699-1701)TTC>TTG	p.F567L	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.F369L|POLK_uc003kec.2_Missense_Mutation_p.F477L|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.F477L	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	567					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AGAAGAGTTTCTTTGATAAAA	0.373								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.001855	0	13	11										G	74892219	C	G	74892219	3	3	19	1	0	0	0	0	1	0	0	0	12204	912	32	1	1747	1	POLK	5	74892219	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	13158985	74892219	106023041	173	5283										
PAPD4	167153	broad.mit.edu	37	chr5	78915520	78915520	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacccttcactccaaatcatCaacaacataataacttcttt	0	14	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:78915520C>T	uc010jae.1	+	3	467	c.49C>T	c.(49-51)CAA>TAA	p.Q17*	PAPD4_uc003kgb.2_Nonsense_Mutation_p.Q17*|PAPD4_uc010jaf.1_Nonsense_Mutation_p.Q17*|PAPD4_uc003kga.2_Nonsense_Mutation_p.Q17*|PAPD4_uc003kfz.2_Nonsense_Mutation_p.Q17*	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	17					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		TCCAAATCATCAACAACATAA	0.393													0	0	0	0.003954	0	20	28										T	78915520	C	T	78915520	4	4	19	1	0	0	0	0	0	1	0	0	11424	827	29	1	51	1	PAPD4	5	78915520	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4023301	78915520	101999740	174	5284										
MTX3	345778	broad.mit.edu	37	chr5	79279583	79279583	+	Missense_Mutation	SNP	G	G	A													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtgttggcagtttccgaggaGgaagctgagggctttggcga							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:79279583G>A	uc010jag.2	-	9	890	c.863C>T	c.(862-864)CCT>CTT	p.P288L	MTX3_uc010jah.2_3'UTR|MTX3_uc003kge.3_Missense_Mutation_p.P227L	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	288					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		TTTCCGAGGAGGAAGCTGAGG	0.468													0	0	0	0.00874	0	32	51										A	79279583	G	A	79279583	3	1	19	1	0	0	0	0	1	0	0	0	9969	1000	35	2	79	2	MTX3	5	79279583	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	364063	79279583	101635677	175	5285	26	2								
MTX3	345778	broad.mit.edu	37	chr5	79279590	79279590	+	Nonsense_Mutation	SNP	G	G	A													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagtttccgaggaggaagctGagggctttggcgaagattgt							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:79279590G>A	uc010jag.2	-	9	883	c.856C>T	c.(856-858)CAG>TAG	p.Q286*	MTX3_uc010jah.2_3'UTR|MTX3_uc003kge.3_Nonsense_Mutation_p.Q225*	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	286					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GGAGGAAGCTGAGGGCTTTGG	0.468													0	0	0	0.01441	0	34	50										A	79279590	G	A	79279590	4	1	19	1	0	0	0	0	0	1	0	0	9969	1299	45	1	86	1	MTX3	5	79279590	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7	79279590	101635670	176	5286	26	2								
FAM81B	153643	broad.mit.edu	37	chr5	94772582	94772582	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agatggtccagggggattatCgccacgaaatgaaccttttg	12	8	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:94772582C>T	uc003kla.1	+	7	911	c.865C>T	c.(865-867)CGC>TGC	p.R289C	FAM81B_uc010jbe.1_Missense_Mutation_p.R85C	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	289										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GGGGGATTATCGCCACGAAAT	0.398													0	0	0	0.004007	0	13	39										T	94772582	C	T	94772582	3	4	19	1	0	0	0	0	1	0	0	0	5629	884	31	1	891	1	FAM81B	5	94772582	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	15492992	94772582	86142678	177	5287										
FBN2	2201	broad.mit.edu	37	chr5	127622542	127622542	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcagcacattcatccagatCtagaacaaaaaataaaaatt	3	8	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:127622542C>G	uc003kuu.2	-	55	7320	c.6881_splice	c.e55-1	p.D2294_splice		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATCCAGATCTAGAACaaaa	0.378													0	0	0	0.001855	0	12	23										G	127622542	C	G	127622542	5	3	19	1	0	0	0	0	0	0	1	0	5703	927	32	1	1902	1	FBN2	5	127622542	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	32849960	127622542	53292718	178	5288										
RAPGEF6	51735	broad.mit.edu	37	chr5	130840372	130840372	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccggtctagttcccgatgctCatgtaccataacaatttctc	6	13	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:130840372C>T	uc003kvn.1	-	11	1407	c.1201G>A	c.(1201-1203)GAG>AAG	p.E401K	RAPGEF6_uc003kvp.1_Missense_Mutation_p.E451K|RAPGEF6_uc003kvo.1_Missense_Mutation_p.E401K|RAPGEF6_uc010jdi.1_Missense_Mutation_p.E401K|RAPGEF6_uc010jdj.1_Missense_Mutation_p.E401K|RAPGEF6_uc003kvq.2_Missense_Mutation_p.E118K|RAPGEF6_uc003kvr.2_Missense_Mutation_p.E401K|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.E401K	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	401					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCCCGATGCTCATGTACCATA	0.383													0	0	0	0.01441	0	41	45										T	130840372	C	T	130840372	3	4	19	1	0	0	0	0	1	0	0	0	13048	835	29	1	4162	1	RAPGEF6	5	130840372	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3217830	130840372	50074888	179	5289										
SLC4A9	83697	broad.mit.edu	37	chr5	139741424	139741424	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccaagaaaggcttctgacaaTgaggaagcccccctgaggga	12	11	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:139741424T>A	uc003lfm.2	+	4	644	c.609T>A	c.(607-609)AAT>AAA	p.N203K	SLC4A9_uc003lfj.2_Missense_Mutation_p.N179K|SLC4A9_uc011czg.1_Missense_Mutation_p.N179K|SLC4A9_uc003lfl.2_Missense_Mutation_p.N179K|SLC4A9_uc003lfk.2_Missense_Mutation_p.N179K	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	203	Cytoplasmic (Potential).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCTGACAATGAGGAAGCCC	0.353													0	0	0	0.01441	0	61	49										A	139741424	T	A	139741424	3	1	19	1	0	0	0	0	1	0	0	0	14660	1461	51	5	551	5	SLC4A9	5	139741424	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	8901052	139741424	41173836	180	5290										
PCDHGA4	56111	broad.mit.edu	37	chr5	140734781	140734781	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggttgtaatggcggcgcctcCtgctcgcccagaccacaccc	11	17	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:140734781C>G	uc003ljq.1	+	1	14	c.14C>G	c.(13-15)CCT>CGT	p.P5R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.P5R	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	5					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGCGCCTCCTGCTCGCCCA	0.602													0	0	0	0.00278	0	22	28										G	140734781	C	G	140734781	3	3	19	1	0	0	0	0	1	0	0	0	11556	681	24	4	16	4	PCDHGA4	5	140734781	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	993357	140734781	40180479	181	5291										
ARAP3	64411	broad.mit.edu	37	chr5	141033813	141033813	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgacttggagagaaagggttGatccaatgacttctggctgg	14	6	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:141033813G>A	uc003llm.2	-	33	4417	c.4339C>T	c.(4339-4341)CAA>TAA	p.Q1447*	ARAP3_uc003lll.2_Nonsense_Mutation_p.Q398*|ARAP3_uc011dbe.1_Nonsense_Mutation_p.Q1096*|ARAP3_uc003lln.2_Nonsense_Mutation_p.Q1278*	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1447					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						AGAAAGGGTTGATCCAATGAC	0.602													0	0	0	0.005524	0	36	44										A	141033813	G	A	141033813	4	1	19	1	0	0	0	0	0	1	0	0	840	1299	45	1	299	1	ARAP3	5	141033813	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	299032	141033813	39881447	182	5292										
FOXC1	2296	broad.mit.edu	37	chr6	1612341	1612341	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctacgactgtagcaagttttGacacaccctcaaagccgaac	7	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:1612341G>A	uc003mtp.2	+	1	1661	c.1661G>A	c.(1660-1662)TGA>TAA	p.*554*		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	554					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		AGCAAGTTTTGACACACCCTC	0.448													0	0	0	0.012319	0	18	86										A	1612341	G	A	1612341	2	1	19	1	0	0	0	0	0	0	0	1	5994	1285	45	1		1	FOXC1	6	1612341	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		1612341	169502726	183	5293										
SERPINB9	5272	broad.mit.edu	37	chr6	2900817	2900817	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttaaaaggcgtatggcaaaaGtaccacttgcattagaaaga	9	6	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:2900817G>T	uc003mug.2	-	2	150	c.29C>A	c.(28-30)ACT>AAT	p.T10N	uc003mue.2_RNA|SERPINB9_uc003muh.2_Missense_Mutation_p.T10N	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	10					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TATGGCAAAAGTACCACTTGC	0.458													1	0	8.06247e-56	0.01441	8.83032e-56	128	234										T	2900817	G	T	2900817	3	4	19	1	0	0	0	0	1	0	0	0	14108	1029	36	4	1125	4	SERPINB9	6	2900817	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1288476	2900817	168214250	184	5294										
RREB1	6239	broad.mit.edu	37	chr6	7247274	7247274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggagacggagggcccctccGacggggagagcgcggccgag	20	12	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:7247274G>A	uc003mxc.2	+	11	4816	c.4426G>A	c.(4426-4428)GAC>AAC	p.D1476N	RREB1_uc003mxb.2_Missense_Mutation_p.D1531N|RREB1_uc010jnx.2_Intron	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	1476					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGGCCCCTCCGACGGGGAGAG	0.672													0	0	0	0.004672	0	3	25										A	7247274	G	A	7247274	3	1	19	1	0	0	0	0	1	0	0	0	13679	1058	37	1	4625	1	RREB1	6	7247274	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4346457	7247274	163867793	185	5295										
PAK1IP1	55003	broad.mit.edu	37	chr6	10697685	10697685	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacatttatgacatgaaaaaGaagattgagcatggggctct	10	6	1	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:10697685G>A	uc003mzg.2	+	2	244	c.213G>A	c.(211-213)AAG>AAA	p.K71K	C6orf52_uc011dij.1_5'Flank|C6orf52_uc011dik.1_5'Flank|C6orf52_uc003mzf.3_5'Flank|C6orf52_uc011dil.1_5'Flank	NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	71	WD 1.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				ACATGAAAAAGAAGATTGAGC	0.393													0	0	0	0.004482	0	7	106										A	10697685	G	A	10697685	2	1	19	1	0	0	0	0	0	0	0	1	11400	933	33	1		1	PAK1IP1	6	10697685	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3450411	10697685	160417382	186	5296										
KIF13A	63971	broad.mit.edu	37	chr6	17809073	17809073	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtgagtttgctcatttcctCagccaggaagtttgcttccc	10	11	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:17809073C>T	uc003ncg.3	-	18	2194	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	KIF13A_uc003ncf.2_Missense_Mutation_p.E697K|KIF13A_uc003nch.3_Missense_Mutation_p.E697K|KIF13A_uc003nci.3_Missense_Mutation_p.E697K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	697	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTCATTTCCTCAGCCAGGAAG	0.488													0	0	0	0.004656	0	23	35										T	17809073	C	T	17809073	3	4	19	1	0	0	0	0	1	0	0	0	8274	835	29	1	3441	1	KIF13A	6	17809073	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	7111388	17809073	153305994	187	5297										
PRSS16	10279	broad.mit.edu	37	chr6	27222869	27222869	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actgcttggacatggcacctGagaggccctcagactccccc	10	16	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:27222869G>A	uc003nja.2	+	11	1447	c.1435G>A	c.(1435-1437)GAG>AAG	p.E479K	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Missense_Mutation_p.E222K|PRSS16_uc003njd.2_RNA	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	479					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						CATGGCACCTGAGAGGCCCTC	0.507													0	0	0	0.01441	0	126	145										A	27222869	G	A	27222869	3	1	19	1	0	0	0	0	1	0	0	0	12616	1291	45	1	1477	1	PRSS16	6	27222869	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	9413796	27222869	143892198	188	5298										
C6orf27	80737	broad.mit.edu	37	chr6	31737803	31737803	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggctgacaggcacatctcaGgctcgtctccaccccccaag	10	17	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:31737803G>A	uc011dog.1	-	8	1413	c.1175C>T	c.(1174-1176)CCT>CTT	p.P392L	C6orf27_uc003nxd.2_Missense_Mutation_p.P67L|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	392						extracellular region				ovary(3)	3						GCACATCTCAGGCTCGTCTCC	0.622													0	0	0	0.004289	0	32	80										A	31737803	G	A	31737803	3	1	19	1	0	0	0	0	1	0	0	0	2362	1000	35	2	1539	2	C6orf27	6	31737803	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4514934	31737803	139377264	189	5299										
ATF6B	1388	broad.mit.edu	37	chr6	32086844	32086844	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccagtccctgcagatactcTttcttctttctccgggactg	7	14	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:32086844T>G	uc003nzn.2	-	10	1074	c.1041A>C	c.(1039-1041)AAA>AAC	p.K347N	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Missense_Mutation_p.K344N|ATF6B_uc003nzp.1_Missense_Mutation_p.K36N	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	347	Cytoplasmic (Potential).|Basic motif.				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCAGATACTCTTTCTTCTTTC	0.607													0	0	0	0.010818	0	24	34										G	32086844	T	G	32086844	3	3	19	1	0	0	0	0	1	0	0	0	1085	1606	56	5	1106	5	ATF6B	6	32086844	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	349041	32086844	139028223	190	5300										
NOTCH4	4855	broad.mit.edu	37	chr6	32166323	32166323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctggcacgtggagggtgggCctgtttcttcagcctttggg	17	9	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:32166323C>T	uc003obb.2	-	26	4770	c.4631G>A	c.(4630-4632)GGC>GAC	p.G1544D	NOTCH4_uc011dpt.1_5'Flank|NOTCH4_uc003oba.2_Missense_Mutation_p.G204D|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_5'Flank	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1544	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGAGGGTGGGCCTGTTTCTTC	0.572													0	0	0	0.007413	0	15	43										T	32166323	C	T	32166323	3	4	19	1	0	0	0	0	1	0	0	0	10551	739	26	2	1400	2	NOTCH4	6	32166323	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	79479	32166323	138948744	191	5301										
SYNGAP1	8831	broad.mit.edu	37	chr6	33400506	33400506	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaaagctccatcaaacgaacGaagtcacaacccaaacttga	5	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:33400506G>A	uc011dri.1	+	5	627	c.432G>A	c.(430-432)ACG>ACA	p.T144T	SYNGAP1_uc003oeo.1_Silent_p.T129T|SYNGAP1_uc010juy.2_Silent_p.T129T	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	144					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						TCAAACGAACGAAGTCACAAC	0.582													0	0	0	0.004656	0	24	61										A	33400506	G	A	33400506	2	1	19	1	0	0	0	0	0	0	0	1	15444	1045	37	1		1	SYNGAP1	6	33400506	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1234183	33400506	137714561	192	5302										
DEF6	50619	broad.mit.edu	37	chr6	35288972	35288972	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctctctgccagataagcgtCcggtcaccagcagctccttc	8	16	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:35288972C>T	uc003okk.2	+	11	1720	c.1681C>T	c.(1681-1683)CCG>TCG	p.P561S	DEF6_uc010jvs.2_Missense_Mutation_p.P536S|DEF6_uc010jvt.2_Missense_Mutation_p.P306S	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	561						cytoplasm|nucleus|plasma membrane					0						AGATAAGCGTCCGGTCACCAG	0.627													0	0	0	0.01441	0	189	298										T	35288972	C	T	35288972	3	4	19	1	0	0	0	0	1	0	0	0	4386	855	30	1	1723	1	DEF6	6	35288972	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1888466	35288972	135826095	193	5303										
TULP1	7287	broad.mit.edu	37	chr6	35478696	35478696	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctgcggagctcttctctctCaggggcttcttgggaggcag	14	11	5	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:35478696C>G	uc003okv.3	-	5	453	c.441G>C	c.(439-441)CTG>CTC	p.L147L	TULP1_uc003okw.3_Silent_p.L94L	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	147					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						TCTTCTCTCTCAGGGGCTTCT	0.413													0	0	0	0.013114	0	41	104										G	35478696	C	G	35478696	2	3	19	1	0	0	0	0	0	0	0	1	16770	813	29	1		1	TULP1	6	35478696	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	189724	35478696	135636371	194	5304										
STK38	11329	broad.mit.edu	37	chr6	36489566	36489566	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttttcattgcatacacatgtCccgtatctttcttctgaaca	4	11	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:36489566C>G	uc003omg.2	-	4	923	c.335G>C	c.(334-336)GGA>GCA	p.G112A	STK38_uc003omh.2_Missense_Mutation_p.G112A|STK38_uc003omi.2_Missense_Mutation_p.G112A	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	112	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						ATACACATGTCCCGTATCTTT	0.358													0	0	0	0.010818	0	31	102										G	36489566	C	G	36489566	3	3	19	1	0	0	0	0	1	0	0	0	15302	855	30	1	1102	1	STK38	6	36489566	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1010870	36489566	134625501	195	5305										
C6orf89	221477	broad.mit.edu	37	chr6	36887410	36887410	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtgaggccatgttgcagctCatccctcccttccagtgccg	11	15	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:36887410C>T	uc003omx.2	+	8	1166	c.882C>T	c.(880-882)CTC>CTT	p.L294L	C6orf89_uc003omv.2_Silent_p.L188L|C6orf89_uc003omw.2_Silent_p.L301L|C6orf89_uc011dtr.1_Silent_p.L188L|C6orf89_uc003omy.2_Silent_p.L128L	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	294						integral to membrane				ovary(1)	1						TGTTGCAGCTCATCCCTCCCT	0.532													0	0	0	0.01441	0	72	79										T	36887410	C	T	36887410	2	4	19	1	0	0	0	0	0	0	0	1	2373	813	29	1		1	C6orf89	6	36887410	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	397844	36887410	134227657	196	5306										
KIF6	221458	broad.mit.edu	37	chr6	39313505	39313505	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agtggggtgctggtgctgctCtgtttctggctgtgtggact	17	7	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:39313505C>G	uc003oot.2	-	21	2387	c.2292G>C	c.(2290-2292)CAG>CAC	p.Q764H	KIF6_uc003oos.2_Missense_Mutation_p.Q215H|KIF6_uc010jwz.1_Missense_Mutation_p.Q139H|KIF6_uc010jxa.1_Missense_Mutation_p.Q538H|KIF6_uc011dua.1_Missense_Mutation_p.Q747H|KIF6_uc010jxb.1_Missense_Mutation_p.Q708H	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	764					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TGGTGCTGCTCTGTTTCTGGC	0.557													0	0	0	0.012213	0	27	37										G	39313505	C	G	39313505	3	3	19	1	0	0	0	0	1	0	0	0	8308	912	32	1	164	1	KIF6	6	39313505	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2426095	39313505	131801562	197	5307										
DAAM2	23500	broad.mit.edu	37	chr6	39846247	39846247	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagacaaagacattggagaaGgaagagatgatgcggacgct	15	5	0	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:39846247G>A	uc003oow.2	+	13	1584	c.1428G>A	c.(1426-1428)AAG>AAA	p.K476K	DAAM2_uc010jxc.2_Silent_p.K476K|DAAM2_uc003oox.2_Silent_p.K476K	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	476	Potential.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CATTGGAGAAGGAAGAGATGA	0.587													0	0	0	0.010729	0	10	13										A	39846247	G	A	39846247	2	1	19	1	0	0	0	0	0	0	0	1	4216	991	35	2		2	DAAM2	6	39846247	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	532742	39846247	131268820	198	5308										
NFYA	4800	broad.mit.edu	37	chr6	41057404	41057404	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagggccagacccagcagatCatcatccagcagccccagac	9	17	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:41057404C>T	uc003opo.2	+	5	574	c.396C>T	c.(394-396)ATC>ATT	p.I132I	NFYA_uc003opp.2_Silent_p.I103I|NFYA_uc003opq.2_Silent_p.I103I	NM_002505	NP_002496	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha isoform 1	132	Gln-rich.				transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCAGCAGATCATCATCCAGC	0.552													0	0	0	0.01441	0	54	75										T	41057404	C	T	41057404	2	4	19	1	0	0	0	0	0	0	0	1	10389	816	29	1		1	NFYA	6	41057404	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1211157	41057404	130057663	199	5309										
TMEM63B	55362	broad.mit.edu	37	chr6	44119725	44119725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctggcgcgctcggccgccGagaggcgcaacgtgaagcgg	18	14	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:44119725G>A	uc003owr.2	+	19	1880	c.1816G>A	c.(1816-1818)GAG>AAG	p.E606K	TMEM63B_uc003ows.2_Missense_Mutation_p.E509K|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	606						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTCGGCCGCCGAGAGGCGCAA	0.677											OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	9	15										A	44119725	G	A	44119725	3	1	19	1	0	0	0	0	1	0	0	0	16188	1059	37	1	1886	1	TMEM63B	6	44119725	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3062321	44119725	126995342	200	5310										
TDRD6	221400	broad.mit.edu	37	chr6	46660819	46660819	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tatgttctcaagagggaaatGactatttctatgaaataata	7	4	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46660819G>C	uc003oyj.2	+	1	4954	c.4954G>C	c.(4954-4956)GAC>CAC	p.D1652H	TDRD6_uc010jze.2_Missense_Mutation_p.D1646H	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1652					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGAGGGAAATGACTATTTCTA	0.378													0	0	0	0.006122	0	17	69										C	46660819	G	C	46660819	3	2	19	1	0	0	0	0	1	0	0	0	15731	1290	45	1	4956	1	TDRD6	6	46660819	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2541094	46660819	124454248	201	5311										
PLA2G7	7941	broad.mit.edu	37	chr6	46678299	46678299	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taccttcagttgttccatatCaaactttaaatctaatgcat	3	9	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46678299C>T	uc010jzf.2	-	8	1029	c.760G>A	c.(760-762)GAT>AAT	p.D254N	PLA2G7_uc010jzg.1_Missense_Mutation_p.D254N|PLA2G7_uc011dwd.1_Missense_Mutation_p.D209N|PLA2G7_uc011dwe.1_Missense_Mutation_p.D127N	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	254					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			TGTTCCATATCAAACTTTAAA	0.333													0	0	0	0.01441	0	43	37										T	46678299	C	T	46678299	3	4	19	1	0	0	0	0	1	0	0	0	12009	826	29	1	585	1	PLA2G7	6	46678299	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	17480	46678299	124436768	202	5312										
MEP1A	4224	broad.mit.edu	37	chr6	46766860	46766860	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagaaatccagaaatggcctGagagacccaaacaccaggtg	10	11	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46766860G>A	uc010jzh.1	+	5	246	c.204G>A	c.(202-204)CTG>CTA	p.L68L	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Silent_p.L96L|MEP1A_uc011dwi.1_5'UTR	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	68	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GAAATGGCCTGAGAGACCCAA	0.428													0	0	0	0.01441	0	37	112										A	46766860	G	A	46766860	2	1	19	1	0	0	0	0	0	0	0	1	9475	1277	45	1		1	MEP1A	6	46766860	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	88561	46766860	124348207	203	5313										
CD2AP	23607	broad.mit.edu	37	chr6	47577018	47577018	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttgaattgttgtgcattgtaGaagcactgaaaaaggatcac	10	5	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:47577018G>C	uc003oyw.2	+	16	2248	c.1792G>C	c.(1792-1794)GAA>CAA	p.E598Q		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	598	Potential.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			GTGCATTGTAGAAGCACTGAA	0.353													0	0	0	0.009096	0	3	150										C	47577018	G	C	47577018	3	2	19	1	0	0	0	0	1	0	0	0	2994	943	33	1	1854	1	CD2AP	6	47577018	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	810158	47577018	123538049	204	5314										
EFHC1	114327	broad.mit.edu	37	chr6	52344529	52344529	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagtattcaccagaagcactCgcgtcaattcagaaccatgt	7	12	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:52344529C>T	uc003pap.3	+	9	1799	c.1584C>T	c.(1582-1584)CTC>CTT	p.L528L	EFHC1_uc011dwv.1_Silent_p.L437L|EFHC1_uc011dww.1_Silent_p.L509L	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	528						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					CAGAAGCACTCGCGTCAATTC	0.478													0	0	0	0.006999	0	39	59										T	52344529	C	T	52344529	2	4	19	1	0	0	0	0	0	0	0	1	4946	871	31	1		1	EFHC1	6	52344529	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4767511	52344529	118770538	205	5315										
C6orf142	90523	broad.mit.edu	37	chr6	53883760	53883760	+	Translation_Start_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aacatgtaagcacgtcgaatCattttctagacagaatctga	7	8	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:53883760C>G	uc003pcg.3	+	1	47	c.-66C>G	c.(-68--64)ATCAT>ATGAT		C6orf142_uc003pcf.2_Translation_Start_Site	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523							nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CACGTCGAATCATTTTCTAGA	0.398													0	0	0	0.000602	0	5	11										G	53883760	C	G	53883760	1	3	19	1	0	0	0	0	0	0	0	0	2333	841	29	1		1	C6orf142	6	53883760	Translation_Start_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1539231	53883760	117231307	206	5316										
DST	667	broad.mit.edu	37	chr6	56497803	56497803	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gattgtagattacttagaacTtgctgatgttcaccaggtag	10	6	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:56497803T>A	uc003pdf.2	-	27	3583	c.3555A>T	c.(3553-3555)CAA>CAT	p.Q1185H	DST_uc003pcz.3_Missense_Mutation_p.Q1007H|DST_uc011dxj.1_Missense_Mutation_p.Q1036H|DST_uc011dxk.1_Missense_Mutation_p.Q1047H|DST_uc003pcy.3_Missense_Mutation_p.Q681H|DST_uc003pdb.2_Missense_Mutation_p.Q681H|DST_uc003pdc.3_Missense_Mutation_p.Q681H|DST_uc003pdd.3_Missense_Mutation_p.Q681H	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1007					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TACTTAGAACTTGCTGATGTT	0.373													0	0	0	0.003271	0	31	43										A	56497803	T	A	56497803	3	1	19	1	0	0	0	0	1	0	0	0	4783	1606	56	5	18396	5	DST	6	56497803	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	2614043	56497803	114617264	207	5317										
ZNF451	26036	broad.mit.edu	37	chr6	57015563	57015563	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttggattacctgcgaaccatGactcatatagtctttgtaga	8	8	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:57015563G>A	uc003pdm.1	+	11	2879	c.2655G>A	c.(2653-2655)ATG>ATA	p.M885I	ZNF451_uc003pdl.2_Missense_Mutation_p.M885I|ZNF451_uc003pdn.1_Intron|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.M885I	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	885					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TGCGAACCATGACTCATATAG	0.363													0	0	0	0.012213	0	29	78										A	57015563	G	A	57015563	3	1	19	1	0	0	0	0	1	0	0	0	17919	1290	45	1	2697	1	ZNF451	6	57015563	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	517760	57015563	114099504	208	5318										
COL12A1	1303	broad.mit.edu	37	chr6	75799843	75799843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tacctcgttccccagggggtCcctgcatccctggtgtgccc	11	17	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:75799843C>T	uc003phs.2	-	63	9090	c.8924G>A	c.(8923-8925)GGA>GAA	p.G2975E	COL12A1_uc003pht.2_Missense_Mutation_p.G1811E	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2975	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCCAGGGGGTCCCTGCATCCC	0.617													0	0	0	0.01441	0	65	115										T	75799843	C	T	75799843	3	4	19	1	0	0	0	0	1	0	0	0	3669	855	30	1	283	1	COL12A1	6	75799843	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	18784280	75799843	95315224	209	5319										
SNX14	57231	broad.mit.edu	37	chr6	86223790	86223790	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acattagaaaatacaaacctCtgagaagtgttatgagtgag	9	5	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:86223790C>G	uc003pkr.2	-	25	2748	c.2555G>C	c.(2554-2556)AGA>ACA	p.R852T	SNX14_uc003pkp.2_Missense_Mutation_p.R715T|SNX14_uc003pkq.2_Missense_Mutation_p.R458T|SNX14_uc011dzg.1_Missense_Mutation_p.R800T|SNX14_uc003pks.2_Missense_Mutation_p.R799T|SNX14_uc003pkt.2_Missense_Mutation_p.R843T	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	852					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ATACAAACCTCTGAGAAGTGT	0.318													0	0	0	0.006999	0	34	36										G	86223790	C	G	86223790	3	3	19	1	0	0	0	0	1	0	0	0	14885	913	32	1	305	1	SNX14	6	86223790	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	10423947	86223790	84891277	210	5320										
BACH2	60468	broad.mit.edu	37	chr6	90647877	90647877	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actcaccaatttgcggatttCacattctaaattctgaatac	4	10	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:90647877C>T	uc011eab.1	-	8	2838	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K	BACH2_uc003pnw.2_Missense_Mutation_p.E677K	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	677	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TTGCGGATTTCACATTCTAAA	0.458													0	0	0	0.010818	0	24	116										T	90647877	C	T	90647877	3	4	19	1	0	0	0	0	1	0	0	0	1284	835	29	1	504	1	BACH2	6	90647877	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4424087	90647877	80467190	211	5321										
COQ3	51805	broad.mit.edu	37	chr6	99823966	99823966	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tactctattctcttatccagGactggatcaaatgatttatg	6	8	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:99823966G>A	uc003ppk.2	-	5	606	c.579C>T	c.(577-579)GTC>GTT	p.V193V		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	193					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		TCTTATCCAGGACTGGATCAA	0.443													0	0	0	0.005524	0	32	134										A	99823966	G	A	99823966	2	1	19	1	0	0	0	0	0	0	0	1	3746	1161	41	1		1	COQ3	6	99823966	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	9176089	99823966	71291101	212	5322										
SEC63	11231	broad.mit.edu	37	chr6	108202384	108202384	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaaggctatacacaggatgtGttatttttgatttggtttcc	9	5	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:108202384G>T	uc003psc.3	-	18	2173	c.1904C>A	c.(1903-1905)ACA>AAA	p.T635K	SEC63_uc003psb.3_Missense_Mutation_p.T495K	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	635	Potential.|Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CACAGGATGTGTTATTTTTGA	0.348													1	0	8.88839e-20	0.010818	9.52996e-20	28	46										T	108202384	G	T	108202384	3	4	19	1	0	0	0	0	1	0	0	0	14005	1377	48	4	394	4	SEC63	6	108202384	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	8378418	108202384	62912683	213	5323										
TRAF3IP2	10758	broad.mit.edu	37	chr6	111913199	111913199	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggagcaggtggttctgattCctcttccggggaatattctg	13	8	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:111913199C>T	uc011ebc.1	-	3	706	c.91G>A	c.(91-93)GAA>AAA	p.E31K	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.E31K|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.E31K|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.E31K|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.E31K	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	40					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		GGTTCTGATTCCTCTTCCGGG	0.463													0	0	0	0.00245	0	12	66										T	111913199	C	T	111913199	3	4	19	1	0	0	0	0	1	0	0	0	16438	864	30	1	1638	1	TRAF3IP2	6	111913199	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3710815	111913199	59201868	214	5324										
MAP3K5	4217	broad.mit.edu	37	chr6	137018501	137018501	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgagctttcctgatgtcattGagtatagattcccggaagta	10	8	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:137018501G>C	uc003qhc.2	-	5	1192	c.831C>G	c.(829-831)CTC>CTG	p.L277L	MAP3K5_uc011edk.1_Silent_p.L122L|MAP3K5_uc010kgw.1_Silent_p.L277L	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	277					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGATGTCATTGAGTATAGATT	0.358													0	0	0	0.007413	0	15	100										C	137018501	G	C	137018501	2	2	19	1	0	0	0	0	0	0	0	1	9253	1277	45	1		1	MAP3K5	6	137018501	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	25105302	137018501	34096566	215	5325										
TAB2	23118	broad.mit.edu	37	chr6	149699347	149699347	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agaaggaagtaggatgaatgGaagtaggactctaacgcaca	13	5	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:149699347G>T	uc003qmj.2	+	3	474	c.296G>T	c.(295-297)GGA>GTA	p.G99V	TAB2_uc011eec.1_Missense_Mutation_p.G67V|TAB2_uc010kia.1_Missense_Mutation_p.G99V|TAB2_uc010kib.1_Missense_Mutation_p.G99V|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	99					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						AGGATGAATGGAAGTAGGACT	0.453													1	0	0.000274275	0.004482	0.000279768	7	67										T	149699347	G	T	149699347	3	4	19	1	0	0	0	0	1	0	0	0	15493	1174	41	3	302	3	TAB2	6	149699347	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	12680846	149699347	21415720	216	5326										
LATS1	9113	broad.mit.edu	37	chr6	150023160	150023160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taaattcctaagggattcccGaatttcttgtaacatttgcc	6	9	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:150023160G>A	uc003qmu.1	-	2	651	c.103C>T	c.(103-105)CGG>TGG	p.R35W	LATS1_uc010kif.1_5'UTR|LATS1_uc003qmv.1_Missense_Mutation_p.R35W|LATS1_uc003qmw.2_Missense_Mutation_p.R35W|LATS1_uc010kig.1_5'UTR	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	35					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGGGATTCCCGAATTTCTTGT	0.423													0	0	0	0.006122	0	16	79										A	150023160	G	A	150023160	3	1	19	1	0	0	0	0	1	0	0	0	8646	1057	37	1	3317	1	LATS1	6	150023160	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	323813	150023160	21091907	217	5327										
AKAP12	9590	broad.mit.edu	37	chr6	151674198	151674198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaaacatcatccagacagccGttgaccagtttgtacgtaca	7	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:151674198G>A	uc011eep.1	+	4	4912	c.4672G>A	c.(4672-4674)GTT>ATT	p.V1558I	AKAP12_uc003qoe.2_Missense_Mutation_p.V1558I|AKAP12_uc003qof.2_Missense_Mutation_p.V1460I|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.V1453I	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1558					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CCAGACAGCCGTTGACCAGTT	0.448													0	0	0	0.003271	0	28	91										A	151674198	G	A	151674198	3	1	19	1	0	0	0	0	1	0	0	0	448	1145	40	2	4711	2	AKAP12	6	151674198	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1651038	151674198	19440869	218	5328										
SYNE1	23345	broad.mit.edu	37	chr6	152640037	152640037	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgaactacattatctgtcttCgctttcagcttagttagaat	6	8	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:152640037C>T	uc010kiw.2	-	85	16952	c.16350G>A	c.(16348-16350)GCG>GCA	p.A5450A	SYNE1_uc010kiv.2_5'Flank|SYNE1_uc003qos.3_5'Flank|SYNE1_uc003qot.3_Silent_p.A5379A|SYNE1_uc003qou.3_Silent_p.A5450A|SYNE1_uc010kiz.2_Silent_p.A1205A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5450	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATCTGTCTTCGCTTTCAGCT	0.378										HNSCC(10;0.0054)			0	0	0	0.004482	0	7	38										T	152640037	C	T	152640037	2	4	19	1	0	0	0	0	0	0	0	1	15442	871	31	1		1	SYNE1	6	152640037	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	965839	152640037	18475030	219	5329										
TIAM2	26230	broad.mit.edu	37	chr6	155451298	155451298	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctggggagcctctccccctCaggtatccgcctttctgatg	10	16	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:155451298C>T	uc003qqb.2	+	6	2214	c.941C>T	c.(940-942)TCA>TTA	p.S314L	TIAM2_uc003qqe.2_Missense_Mutation_p.S314L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	314					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTCTCCCCCTCAGGTATCCGC	0.557													0	0	0	0.00333	0	21	30										T	155451298	C	T	155451298	3	4	19	1	0	0	0	0	1	0	0	0	15888	838	29	1	943	1	TIAM2	6	155451298	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2811261	155451298	15663769	220	5330										
SNX8	29886	broad.mit.edu	37	chr7	2311494	2311494	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacacactcaccgagccgctGaaggacaggaagagcttgag	13	11	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:2311494G>A	uc003slw.2	-	4	574	c.531C>T	c.(529-531)TTC>TTT	p.F177F		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	177	PX.				cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CCGAGCCGCTGAAGGACAGGA	0.637													0	0	0	0.000602	0	5	10										A	2311494	G	A	2311494	2	1	19	1	0	0	0	0	0	0	0	1	14908	1281	45	1		1	SNX8	7	2311494	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		2311494	156827169	221	5331										
SDK1	221935	broad.mit.edu	37	chr7	4189070	4189070	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actcctcgtccatcagccatGaggcgacagcatgcgtcgtt	10	14	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:4189070G>A	uc003smx.2	+	30	4739	c.4600G>A	c.(4600-4602)GAG>AAG	p.E1534K	SDK1_uc010kso.2_Missense_Mutation_p.E810K|SDK1_uc003smy.2_Missense_Mutation_p.E21K	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1534	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CATCAGCCATGAGGCGACAGC	0.667													0	0	0	0.013537	0	8	10										A	4189070	G	A	4189070	3	1	19	1	0	0	0	0	1	0	0	0	13968	1291	45	1	4718	1	SDK1	7	4189070	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1877576	4189070	154949593	222	5332										
CCDC129	223075	broad.mit.edu	37	chr7	31682389	31682389	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tagtatcatcccaggactgtCagctagagtcggatgggcca	12	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:31682389C>T	uc003tcj.1	+	11	2398	c.1405C>T	c.(1405-1407)CAG>TAG	p.Q469*	CCDC129_uc011kad.1_Nonsense_Mutation_p.Q479*|CCDC129_uc003tci.1_Nonsense_Mutation_p.Q320*|CCDC129_uc011kae.1_Nonsense_Mutation_p.Q495*|CCDC129_uc003tck.1_Nonsense_Mutation_p.Q377*	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	469											0						CCAGGACTGTCAGCTAGAGTC	0.502													0	0	0	0.013537	0	11	107										T	31682389	C	T	31682389	4	4	19	1	0	0	0	0	0	1	0	0	2764	827	29	1	1443	1	CCDC129	7	31682389	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	27493319	31682389	127456274	223	5333										
MRPS24	64951	broad.mit.edu	37	chr7	43908565	43908565	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctggggtccgctcacctgTgtgcagcgacagccagcctt	13	15	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:43908565T>C	uc003tit.1	-	3	268	c.217A>G	c.(217-219)ACA>GCA	p.T73A		NM_032014	NP_114403	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24 precursor	73					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CGCTCACCTGTGTGCAGCGAC	0.458													0	0	0	0.01441	0	52	71										C	43908565	T	C	43908565	3	2	19	1	0	0	0	0	1	0	0	0	9835	1696	59	5	294	5	MRPS24	7	43908565	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	12226176	43908565	115230098	224	5334										
PKD1L1	168507	broad.mit.edu	37	chr7	47886526	47886526	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggttgtggagagaaacgttCagatttccactctctcttgt	10	8	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:47886526C>T	uc003tny.1	-	32	5104	c.5104G>A	c.(5104-5106)GAA>AAA	p.E1702K		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1702	Extracellular (Potential).|GPS.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GAGAAACGTTCAGATTTCCAC	0.408													0	0	0	0.005524	0	31	79										T	47886526	C	T	47886526	3	4	19	1	0	0	0	0	1	0	0	0	11964	835	29	1	3549	1	PKD1L1	7	47886526	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3977961	47886526	111252137	225	5335										
VWC2	375567	broad.mit.edu	37	chr7	49815164	49815164	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggcaccagagcagccgggcCaggagaagcgtgagcacgcc	16	13	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:49815164C>G	uc003tot.1	+	2	689	c.133C>G	c.(133-135)CAG>GAG	p.Q45E		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	45					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						GCAGCCGGGCCAGGAGAAGCG	0.716													0	0	0	0.006214	0	9	6										G	49815164	C	G	49815164	3	3	19	1	0	0	0	0	1	0	0	0	17240	595	21	4	135	4	VWC2	7	49815164	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1928638	49815164	109323499	226	5336										
MRPS17	51373	broad.mit.edu	37	chr7	56022758	56022758	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagttggaaaagtcatagatCcagtgacaggaaagccctgt	11	7	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:56022758C>T	uc003trd.2	+	3	310	c.280C>T	c.(280-282)CCA>TCA	p.P94S	MRPS17_uc003trb.2_Missense_Mutation_p.P189S	NM_015969	NP_057053	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17 precursor	94					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGTCATAGATCCAGTGACAGG	0.458													0	0	0	0.007291	0	29	90										T	56022758	C	T	56022758	3	4	19	1	0	0	0	0	1	0	0	0	9827	855	30	1	286	1	MRPS17	7	56022758	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6207594	56022758	103115905	227	5337										
SEMA3A	10371	broad.mit.edu	37	chr7	83764184	83764184	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccaacatacagcctactccGttcctcatccaaaaggaagg	6	14	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:83764184G>A	uc003uhz.2	-	2	511	c.196C>T	c.(196-198)CGG>TGG	p.R66W		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	66	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						AGCCTACTCCGTTCCTCATCC	0.388													0	0	0	0.000602	0	3	72										A	83764184	G	A	83764184	3	1	19	1	0	0	0	0	1	0	0	0	14024	1144	40	2	2183	2	SEMA3A	7	83764184	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	27741426	83764184	75374479	228	5338										
SPDYE3	441272	broad.mit.edu	37	chr7	99917593	99917593	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcactgggtgtgggcgcgaGatcgcgcccacctttcctag	14	13	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:99917593G>A	uc003uug.1	+	5	739	c.499G>A	c.(499-501)GAT>AAT	p.D167N	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	544											0						GTGGGCGCGAGATCGCGCCCA	0.582													0	0	0	0.012213	0	27	18										A	99917593	G	A	99917593	3	1	19	1	0	0	0	0	1	0	0	0	15029	942	33	1	1668	1	SPDYE3	7	99917593	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	16153409	99917593	59221070	229	5339										
SRRT	51593	broad.mit.edu	37	chr7	100485992	100485992	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccagggaggttatcctgggaAacctcgcaacaggtgaggag	15	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:100485992A>C	uc003uwy.2	+	20	2811	c.2543A>C	c.(2542-2544)AAA>ACA	p.K848T	SRRT_uc010lhl.1_Missense_Mutation_p.K847T|SRRT_uc003uxa.2_Missense_Mutation_p.K843T|SRRT_uc003uwz.2_Missense_Mutation_p.K844T|uc010lhm.1_5'Flank	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	848					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TATCCTGGGAAACCTCGCAAC	0.612													0	0	0	0.013537	0	11	13										C	100485992	A	C	100485992	3	2	19	1	0	0	0	0	1	0	0	0	15171	14	1	5	2613	5	SRRT	7	100485992	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	568399	100485992	58652671	230	5340										
LAMB4	22798	broad.mit.edu	37	chr7	107746973	107746973	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccttggatgtaggggctataAgggttttcaatttcaaaact	10	6	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:107746973A>C	uc010ljo.1	-	7	720	c.636T>G	c.(634-636)CCT>CCG	p.P212P	LAMB4_uc003vey.2_Silent_p.P212P	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	212	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AGGGGCTATAAGGGTTTTCAA	0.269													0	0	0	0.010729	0	11	7										C	107746973	A	C	107746973	2	2	19	1	0	0	0	0	0	0	0	1	8613	59	3	5		5	LAMB4	7	107746973	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	7260981	107746973	51391690	231	5341										
AKR1D1	6718	broad.mit.edu	37	chr7	137798473	137798473	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cactgaagaagaaatgaaggAcattgaagccttgaataaaa	9	5	0	6			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:137798473A>G	uc003vtz.2	+	8	962	c.893A>G	c.(892-894)GAC>GGC	p.D298G	AKR1D1_uc011kqe.1_Intron|AKR1D1_uc011kqf.1_Missense_Mutation_p.D257G|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	298					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						GAAATGAAGGACATTGAAGCC	0.388													0	0	0	0.006122	0	13	23										G	137798473	A	G	137798473	3	3	19	1	0	0	0	0	1	0	0	0	473	275	10	5	923	5	AKR1D1	7	137798473	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	30051500	137798473	21340190	232	5342										
ZYX	7791	broad.mit.edu	37	chr7	143079495	143079495	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccttccccgccgcctcctccGgaggaggagggagggcctga	15	16	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:143079495G>A	uc003wcw.2	+	3	518	c.363G>A	c.(361-363)CCG>CCA	p.P121P	ZYX_uc011ktd.1_5'UTR|ZYX_uc003wcx.2_Silent_p.P121P|ZYX_uc011kte.1_Silent_p.P121P|ZYX_uc011ktf.1_5'UTR	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	121	Pro-rich.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CGCCTCCTCCGGAGGAGGAGG	0.697													0	0	0	0.004007	0	14	17										A	143079495	G	A	143079495	2	1	19	1	0	0	0	0	0	0	0	1	18251	1103	39	2		2	ZYX	7	143079495	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5281022	143079495	16059168	233	5343										
MLL3	58508	broad.mit.edu	37	chr7	151896487	151896487	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccatcttctgacagattatCtaaacttatcttgctttgtc	4	10	4	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:151896487C>T	uc003wla.2	-	27	4369	c.4150G>A	c.(4150-4152)GAT>AAT	p.D1384N	MLL3_uc003wkz.2_Missense_Mutation_p.D445N	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1384					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GACAGATTATCTAAACTTATC	0.348			N		medulloblastoma								0	0	0	0.00499	0	16	13										T	151896487	C	T	151896487	3	4	19	1	0	0	0	0	1	0	0	0	9622	913	32	1	10717	1	MLL3	7	151896487	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8816992	151896487	7242176	234	5344										
PSD3	23362	broad.mit.edu	37	chr8	18729886	18729886	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccacctgctgaactgaaaaaCtagaaacagcatcttggtcc	7	12	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:18729886C>T	uc003wza.2	-	3	591	c.488G>A	c.(487-489)AGT>AAT	p.S163N		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	163					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		AACTGAAAAACTAGAAACAGC	0.443													0	0	0	0.006214	0	9	31										T	18729886	C	T	18729886	3	4	19	1	0	0	0	0	1	0	0	0	12648	565	20	2	2747	2	PSD3	8	18729886	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		18729886	127634136	235	5345										
SCARA5	286133	broad.mit.edu	37	chr8	27737165	27737165	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacaccacgtctccgtccttCttgtcccagccgtcgtcaca	6	19	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:27737165C>T	uc003xgj.2	-	8	1712	c.1272G>A	c.(1270-1272)AAG>AAA	p.K424K	SCARA5_uc010luz.2_Silent_p.K199K	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	424	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CTCCGTCCTTCTTGTCCCAGC	0.642													0	0	0	0.005524	0	32	118										T	27737165	C	T	27737165	2	4	19	1	0	0	0	0	0	0	0	1	13880	912	32	1		1	SCARA5	8	27737165	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9007279	27737165	118626857	236	5346										
HGSNAT	138050	broad.mit.edu	37	chr8	43053085	43053085	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgtggacaggaaccccattCttttatccaggtaagtcacc	8	12	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:43053085C>G	uc003xpx.3	+	17	1764	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	600	Helical; (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GAACCCCATTCTTTTATCCAG	0.547													0	0	0	0.001984	0	6	35										G	43053085	C	G	43053085	3	3	19	1	0	0	0	0	1	0	0	0	7088	912	32	1	1782	1	HGSNAT	8	43053085	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	15315920	43053085	103310937	237	5347										
CHD7	55636	broad.mit.edu	37	chr8	61754499	61754499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgatggagttctcagacttgGaaagtgattctgaagaaaag	12	4	2	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:61754499G>A	uc003xue.2	+	21	5215	c.4738G>A	c.(4738-4740)GAA>AAA	p.E1580K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1580					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTCAGACTTGGAAAGTGATTC	0.468													0	0	0	0.000602	0	5	17										A	61754499	G	A	61754499	3	1	19	1	0	0	0	0	1	0	0	0	3330	1175	41	1	4816	1	CHD7	8	61754499	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	18701414	61754499	84609523	238	5348										
BHLHE22	27319	broad.mit.edu	37	chr8	65494338	65494338	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cggcggctgcagcggcagcaGctgctgccctgcacccggcg	16	17	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:65494338G>A	uc003xvi.2	+	1	1525	c.991G>A	c.(991-993)GCT>ACT	p.A331T	LOC401463_uc003xvh.2_5'UTR	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	331	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCGGCAGCAGCTGCTGCCCT	0.741													0	0	0	0.000602	0	4	5										A	65494338	G	A	65494338	3	1	19	1	0	0	0	0	1	0	0	0	1421	971	34	2	993	2	BHLHE22	8	65494338	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3739839	65494338	80869684	239	5349										
TRAM1	23471	broad.mit.edu	37	chr8	71510491	71510491	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgattcagtagcttgttcttCtgaagaccaaaaaggacaca	8	8	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:71510491C>T	uc003xyo.1	-	3	358	c.188_splice	c.e3-1	p.E63_splice	TRAM1_uc011lfc.1_Splice_Site_p.E32_splice	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1						cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GCTTGTTCTTCTGAAGACCAA	0.333													0	0	0	0.003163	0	13	35										T	71510491	C	T	71510491	5	4	19	1	0	0	0	0	0	0	1	0	16448	927	32	1	973	1	TRAM1	8	71510491	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6016153	71510491	74853531	240	5350										
KIAA1429	25962	broad.mit.edu	37	chr8	95547204	95547204	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccagtgtcagacagttatacCagcctcttagcaccagacca	7	14	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:95547204C>T	uc003ygo.1	-	5	360	c.347G>A	c.(346-348)TGG>TAG	p.W116*	KIAA1429_uc003ygp.2_Nonsense_Mutation_p.W116*	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	116					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ACAGTTATACCAGCCTCTTAG	0.343													0	0	0	0.01441	0	41	158										T	95547204	C	T	95547204	4	4	19	1	0	0	0	0	0	1	0	0	8231	595	21	2	5225	2	KIAA1429	8	95547204	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	24036713	95547204	50816818	241	5351										
FZD6	8323	broad.mit.edu	37	chr8	104337528	104337528	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccttaaatcatgttcgacaAgtcatacaacatgatggccg	7	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:104337528A>C	uc003ylh.2	+	4	1478	c.1194A>C	c.(1192-1194)CAA>CAC	p.Q398H	FZD6_uc003yli.2_Missense_Mutation_p.Q398H|FZD6_uc003ylj.2_Missense_Mutation_p.Q398H|FZD6_uc011lhn.1_Missense_Mutation_p.Q364H|FZD6_uc011lho.1_Missense_Mutation_p.Q93H|FZD6_uc011lhp.1_Missense_Mutation_p.Q343H	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	398	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATGTTCGACAAGTCATACAAC	0.408													0	0	0	0.01441	0	68	194										C	104337528	A	C	104337528	3	2	19	1	0	0	0	0	1	0	0	0	6134	69	3	5	1204	5	FZD6	8	104337528	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	8790324	104337528	42026494	242	5352										
KCNV1	27012	broad.mit.edu	37	chr8	110984991	110984991	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttcttgaagtctaaagtttCactcagctctttccttctga	5	11	6	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:110984991C>G	uc003ynr.3	-	2	829	c.487G>C	c.(487-489)GAA>CAA	p.E163Q	KCNV1_uc010mcw.2_Missense_Mutation_p.E163Q	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	163	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TCTAAAGTTTCACTCAGCTCT	0.383													0	0	0	0.01441	0	54	76										G	110984991	C	G	110984991	3	3	19	1	0	0	0	0	1	0	0	0	8094	835	29	1	1023	1	KCNV1	8	110984991	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6647463	110984991	35379031	243	5353										
CSMD3	114788	broad.mit.edu	37	chr8	113304838	113304838	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctttgttggcccttgcataaGatacccaatattgcatgaga	8	9	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:113304838G>A	uc003ynu.2	-	55	8875	c.8716C>T	c.(8716-8718)CTT>TTT	p.L2906F	CSMD3_uc003yns.2_Missense_Mutation_p.L2108F|CSMD3_uc003ynt.2_Missense_Mutation_p.L2866F|CSMD3_uc011lhx.1_Missense_Mutation_p.L2737F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2906	Extracellular (Potential).|Sushi 19.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTTGCATAAGATACCCAATA	0.438										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.01441	0	49	156										A	113304838	G	A	113304838	3	1	19	1	0	0	0	0	1	0	0	0	3946	942	33	1	2475	1	CSMD3	8	113304838	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2319847	113304838	33059184	244	5354										
CSMD3	114788	broad.mit.edu	37	chr8	113363413	113363413	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttttaacttacctaaacaaaTtgggattggataattccatc	5	7	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:113363413T>C	uc003ynu.2	-	40	6475	c.6316A>G	c.(6316-6318)ATT>GTT	p.I2106V	CSMD3_uc003yns.2_Missense_Mutation_p.I1308V|CSMD3_uc003ynt.2_Missense_Mutation_p.I2066V|CSMD3_uc011lhx.1_Missense_Mutation_p.I2002V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2106	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTAAACAAATTGGGATTGGA	0.303										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.006122	0	15	85										C	113363413	T	C	113363413	3	2	19	1	0	0	0	0	1	0	0	0	3946	1493	52	5	4935	5	CSMD3	8	113363413	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	58575	113363413	33000609	245	5355										
RAD21	5885	broad.mit.edu	37	chr8	117864827	117864827	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgctgctgttgctggtcctCtctaggaacctctggatttt	10	10	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:117864827C>A	uc003yod.2	-	10	1570	c.1282G>T	c.(1282-1284)GAG>TAG	p.E428*		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	428					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TGCTGGTCCTCTCTAGGAACC	0.413													1	0	6.33239e-15	0.010504	6.70875e-15	18	126										A	117864827	C	A	117864827	4	1	19	1	0	0	0	0	0	1	0	0	12981	922	32	3	633	3	RAD21	8	117864827	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4501414	117864827	28499195	246	5356										
TG	7038	broad.mit.edu	37	chr8	133899037	133899037	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccagcaaaacctttttggaGggaaatttttggtgaatgtt	10	5	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:133899037G>C	uc003ytw.2	+	9	1461	c.1420G>C	c.(1420-1422)GGG>CGG	p.G474R		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	474					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCTTTTTGGAGGGAAATTTTT	0.473													0	0	0	0.012213	0	32	41										C	133899037	G	C	133899037	3	2	19	1	0	0	0	0	1	0	0	0	15810	1000	35	4	1454	4	TG	8	133899037	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	16034210	133899037	12464985	247	5357										
ZNF251	90987	broad.mit.edu	37	chr8	145947530	145947530	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgtgaactttctgatgctgAatgagggttgacctccggct	12	9	1	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:145947530A>C	uc003zdv.3	-	5	1771	c.1515T>G	c.(1513-1515)ATT>ATG	p.I505M		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	505	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTGATGCTGAATGAGGGTTG	0.537													0	0	0	0.01441	0	64	66										C	145947530	A	C	145947530	3	2	19	1	0	0	0	0	1	0	0	0	17793	242	9	5	504	5	ZNF251	8	145947530	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	12048493	145947530	416492	248	5358										
FREM1	158326	broad.mit.edu	37	chr9	14740152	14740152	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcccagatacttgcctatcCaaaaggactttctcccacca	4	16	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:14740152C>G	uc003zlm.2	-	36	6925	c.6335G>C	c.(6334-6336)TGG>TCG	p.W2112S	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.W648S	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2112	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTGCCTATCCAAAAGGACTT	0.498													0	0	0	0.006999	0	31	170										G	14740152	C	G	14740152	3	3	19	1	0	0	0	0	1	0	0	0	6044	595	21	4	212	4	FREM1	9	14740152	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		14740152	126473279	249	5359										
VCP	7415	broad.mit.edu	37	chr9	35059694	35059694	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctgtcaggatctggttgatGactcggtcagcagccccacc	11	13	4	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:35059694G>A	uc003zvy.2	-	14	2189	c.1800C>T	c.(1798-1800)GTC>GTT	p.V600V	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Silent_p.V269V|VCP_uc010mki.1_Silent_p.V555V	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	600					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCTGGTTGATGACTCGGTCAG	0.512													0	0	0	0.01441	0	111	102										A	35059694	G	A	35059694	2	1	19	1	0	0	0	0	0	0	0	1	17137	1277	45	1		1	VCP	9	35059694	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	20319542	35059694	106153737	250	5360										
DCAF10	79269	broad.mit.edu	37	chr9	37861326	37861326	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggattcgcttgttgggatttGacaaacagtgcagtgaactt	12	6	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:37861326G>A	uc004aao.2	+	7	1575	c.1501G>A	c.(1501-1503)GAC>AAC	p.D501N	DCAF10_uc010mlz.2_Missense_Mutation_p.D328N|DCAF10_uc004aap.2_Missense_Mutation_p.D152N	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	501	WD 6.					CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						GTTGGGATTTGACAAACAGTG	0.488													0	0	0	0.005524	0	36	127										A	37861326	G	A	37861326	3	1	19	1	0	0	0	0	1	0	0	0	4261	1290	45	1	1527	1	DCAF10	9	37861326	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2801632	37861326	103352105	251	5361										
FAM122A	116224	broad.mit.edu	37	chr9	71395443	71395443	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cactcctgggaggaaagtttCagcctgagtgacaacgacgt	12	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:71395443C>T	uc004agw.1	+	1	480	c.363C>T	c.(361-363)TTC>TTT	p.F121F	PIP5K1B_uc004agu.2_Intron|PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	121											0						AGGAAAGTTTCAGCCTGAGTG	0.557													0	0	0	0.01441	0	108	173										T	71395443	C	T	71395443	2	4	19	1	0	0	0	0	0	0	0	1	5419	825	29	1		1	FAM122A	9	71395443	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	33534117	71395443	69817988	252	5362										
APBA1	320	broad.mit.edu	37	chr9	72091005	72091005	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacagggtcactggggtgaaGagatgtgcttgatgactctg	15	7	2	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:72091005G>C	uc004ahh.2	-	3	1531	c.1255C>G	c.(1255-1257)CTT>GTT	p.L419V		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	419	LIN-2/CASK binding.|Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						CTGGGGTGAAGAGATGTGCTT	0.498													0	0	0	0.007413	0	16	55										C	72091005	G	C	72091005	3	2	19	1	0	0	0	0	1	0	0	0	756	942	33	1	1302	1	APBA1	9	72091005	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	695562	72091005	69122426	253	5363										
FLJ46321	389763	broad.mit.edu	37	chr9	84609239	84609239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttacagaagtgtcaagttaCgaatttcccaccagctgtaa	7	10	1	1	rs115598379	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:84609239C>T	uc004amn.2	+	4	3901	c.3854C>T	c.(3853-3855)ACG>ATG	p.T1285M		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1285						integral to membrane					0						TGTCAAGTTACGAATTTCCCA	0.562													0	0	0	0.00245	0	13	22										T	84609239	C	T	84609239	3	4	19	1	0	0	0	0	1	0	0	0	5932	536	19	2	3868	2	FLJ46321	9	84609239	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	12518234	84609239	56604192	254	5364										
SLC28A3	64078	broad.mit.edu	37	chr9	86917263	86917263	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaaaagaggaagggctctgtGaaagttcagcacacaggccg	13	8	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:86917263G>A	uc010mpz.2	-	5	501	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	SLC28A3_uc011lsy.1_Missense_Mutation_p.H57Y|SLC28A3_uc004anu.1_Missense_Mutation_p.H126Y|SLC28A3_uc010mqb.2_Missense_Mutation_p.H57Y	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	126	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						AGGGCTCTGTGAAAGTTCAGC	0.483													0	0	0	0.00308	0	7	20										A	86917263	G	A	86917263	3	1	19	1	0	0	0	0	1	0	0	0	14533	1290	45	1	1755	1	SLC28A3	9	86917263	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2308024	86917263	54296168	255	5365										
NXNL2	158046	broad.mit.edu	37	chr9	91150578	91150578	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgtcagccgacggcagctccCaggagatgctggacttcatg	13	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:91150578C>T	uc011ltj.1	+	1	563	c.229C>T	c.(229-231)CAG>TAG	p.Q77*	NXNL2_uc004aqa.2_Nonsense_Mutation_p.Q77*	NM_001161625	NP_001155097	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2 isoform 1	77	Thioredoxin.										0						CGGCAGCTCCCAGGAGATGCT	0.647													0	0	0	0.010504	0	18	30										T	91150578	C	T	91150578	4	4	19	1	0	0	0	0	0	1	0	0	10789	595	21	2	231	2	NXNL2	9	91150578	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4233315	91150578	50062853	256	5366										
FAM120AOS	158293	broad.mit.edu	37	chr9	96212868	96212868	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgtcggttgcatcctgctcCtctacagaggtttctccaaa	8	13	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:96212868C>A	uc004atu.3	-	2	1460	c.577G>T	c.(577-579)GGA>TGA	p.G193*	FAM120AOS_uc004atm.2_RNA|FAM120AOS_uc004atn.3_RNA|FAM120AOS_uc004ato.3_RNA|FAM120AOS_uc004atp.3_RNA|FAM120AOS_uc004atq.3_RNA|FAM120AOS_uc004atr.3_RNA|FAM120AOS_uc004ats.3_RNA|FAM120AOS_uc004att.3_RNA|FAM120A_uc004atv.2_5'Flank|FAM120A_uc004atw.2_5'Flank	NM_198841	NP_942138	Q5T036	F120S_HUMAN	hypothetical protein LOC158293	193											0						CATCCTGCTCCTCTACAGAGG	0.493													1	0	0.000274275	0.004482	0.000279768	8	27										A	96212868	C	A	96212868	4	1	19	1	0	0	0	0	0	1	0	0	5416	690	24	4	201	4	FAM120AOS	9	96212868	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5062290	96212868	45000563	257	5367										
C9orf3	84909	broad.mit.edu	37	chr9	97844896	97844896	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acggggagctgatggtgagtGaggacgccagacagcagcag	18	8	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:97844896G>A	uc004ava.2	+	15	2494	c.2359G>A	c.(2359-2361)GAG>AAG	p.E787K	C9orf3_uc004auy.2_Missense_Mutation_p.E688K|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Missense_Mutation_p.E149K|C9orf3_uc011luk.1_Missense_Mutation_p.E128K|C9orf3_uc004avd.2_Missense_Mutation_p.E149K|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	787					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GATGGTGAGTGAGGACGCCAG	0.597													0	0	0	0.003755	0	32	51										A	97844896	G	A	97844896	3	1	19	1	0	0	0	0	1	0	0	0	2477	1291	45	1	2112	1	C9orf3	9	97844896	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1632028	97844896	43368535	258	5368										
C9orf102	375748	broad.mit.edu	37	chr9	98660185	98660185	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agggaactcgtgaggatattGaaaataacatgccagagttt	11	5	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:98660185G>C	uc004avt.3	+	3	947	c.559G>C	c.(559-561)GAA>CAA	p.E187Q	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_5'UTR|C9orf102_uc010mry.1_5'UTR|C9orf102_uc010mrz.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	187	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				TGAGGATATTGAAAATAACAT	0.333													0	0	0	0.00333	0	20	65										C	98660185	G	C	98660185	3	2	19	1	0	0	0	0	1	0	0	0	2445	1291	45	1	569	1	C9orf102	9	98660185	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	815289	98660185	42553246	259	5369										
FAM22G	441457	broad.mit.edu	37	chr9	99691320	99691320	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgaggggatggcttcaaatgGaggtgagcctgtagggatgg	19	4	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:99691320G>C	uc004awq.1	+	1	729	c.14G>C	c.(13-15)GGA>GCA	p.G5A		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	5										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GCTTCAAATGGAGGTGAGCCT	0.537													0	0	0	0.01441	0	91	106										C	99691320	G	C	99691320	3	2	19	1	0	0	0	0	1	0	0	0	5546	1174	41	1	16	1	FAM22G	9	99691320	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1031135	99691320	41522111	260	5370										
LPPR1	54886	broad.mit.edu	37	chr9	104032211	104032211	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcctactacttcgaatgcaCtgacacttttcaggtgcata	7	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:104032211C>A	uc004bbb.2	+	3	512	c.113C>A	c.(112-114)ACT>AAT	p.T38N	LPPR1_uc011lvi.1_Missense_Mutation_p.T14N|LPPR1_uc004bbc.2_Missense_Mutation_p.T38N|LPPR1_uc010mtc.2_Missense_Mutation_p.T22N	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	38						integral to membrane	catalytic activity				0						TTCGAATGCACTGACACTTTT	0.502													1	0	5.03518e-11	0.007413	5.28731e-11	18	70										A	104032211	C	A	104032211	3	1	19	1	0	0	0	0	1	0	0	0	8924	565	20	4	119	4	LPPR1	9	104032211	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4340891	104032211	37181220	261	5371										
ZNF462	58499	broad.mit.edu	37	chr9	109688717	109688717	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actttggtgactctggaaggCtttactattgtaaacactgt	9	7	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:109688717C>A	uc004bcz.2	+	3	2813	c.2524C>A	c.(2524-2526)CTT>ATT	p.L842I	ZNF462_uc010mto.2_Missense_Mutation_p.L690I|ZNF462_uc004bda.2_Missense_Mutation_p.L690I	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	842					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CTCTGGAAGGCTTTACTATTG	0.423													1	0	1.39921e-30	0.01441	1.52079e-30	71	109										A	109688717	C	A	109688717	3	1	19	1	0	0	0	0	1	0	0	0	17923	797	28	4	2530	4	ZNF462	9	109688717	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5656506	109688717	31524714	262	5372										
PTPN3	5774	broad.mit.edu	37	chr9	112225592	112225592	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttacagtaactttaaaggtCtgtaccacgccatctaaaaa	5	10	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:112225592C>T	uc004bed.2	-	2	235	c.123G>A	c.(121-123)CAG>CAA	p.Q41Q	PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.Q41Q|PTPN3_uc011lwh.1_5'UTR|PTPN3_uc004bee.3_Silent_p.Q41Q	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	41	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CTTTAAAGGTCTGTACCACGC	0.358													0	0	0	0.005443	0	25	43										T	112225592	C	T	112225592	2	4	19	1	0	0	0	0	0	0	0	1	12789	912	32	1		1	PTPN3	9	112225592	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2536875	112225592	28987839	263	5373										
TNFSF15	9966	broad.mit.edu	37	chr9	117568272	117568272	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggctgtttccccaaagctCagtcccagatcctcggccat	8	16	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:117568272C>T	uc004bjh.2	-	1	137	c.21G>A	c.(19-21)CTG>CTA	p.L7L		NM_005118	NP_005109	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily,	7	Cytoplasmic (Potential).				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding				0						CCCCAAAGCTCAGTCCCAGAT	0.622													0	0	0	0.01441	0	43	87										T	117568272	C	T	117568272	2	4	19	1	0	0	0	0	0	0	0	1	16305	813	29	1		1	TNFSF15	9	117568272	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5342680	117568272	23645159	264	5374										
RABEPK	10244	broad.mit.edu	37	chr9	127990287	127990287	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggacaaagctcttcatccacGgaggcttggcgggggacaga	15	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:127990287G>A	uc004bpi.2	+	7	798	c.625G>A	c.(625-627)GGA>AGA	p.G209R	RABEPK_uc004bpj.2_Missense_Mutation_p.G158R|RABEPK_uc004bpk.2_Missense_Mutation_p.G209R|RABEPK_uc004bpl.1_Missense_Mutation_p.G158R|RABEPK_uc004bpm.2_Missense_Mutation_p.G209R	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	209	Kelch 4.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						CTTCATCCACGGAGGCTTGGC	0.488													0	0	0	0.001984	0	7	50										A	127990287	G	A	127990287	3	1	19	1	0	0	0	0	1	0	0	0	12963	1117	39	2	643	2	RABEPK	9	127990287	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	10422015	127990287	13223144	265	5375										
GAPVD1	26130	broad.mit.edu	37	chr9	128074826	128074826	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcaggaggtgcaaccagaaGaggtgttggtcatttcctta	12	7	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:128074826G>C	uc010mwx.2	+	9	1863	c.1537G>C	c.(1537-1539)GAG>CAG	p.E513Q	GAPVD1_uc011lzs.1_Missense_Mutation_p.E513Q|GAPVD1_uc004bpp.2_Missense_Mutation_p.E513Q|GAPVD1_uc004bpq.2_Missense_Mutation_p.E513Q|GAPVD1_uc004bpr.2_Missense_Mutation_p.E513Q|GAPVD1_uc004bps.2_Missense_Mutation_p.E513Q|GAPVD1_uc010mwy.1_Missense_Mutation_p.E372Q	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	513					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GCAACCAGAAGAGGTGTTGGT	0.433													0	0	0	0.01441	0	35	55										C	128074826	G	C	128074826	3	2	19	1	0	0	0	0	1	0	0	0	6239	943	33	1	1559	1	GAPVD1	9	128074826	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	84539	128074826	13138605	266	5376										
GARNL3	84253	broad.mit.edu	37	chr9	130119513	130119513	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacaggagatctgtctgtctGactctcccatggtgatgacc	10	12	4	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:130119513G>T	uc011mae.1	+	21	2352	c.1951G>T	c.(1951-1953)GAC>TAC	p.D651Y	GARNL3_uc011mad.1_Missense_Mutation_p.D629Y|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	651	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGTCTGTCTGACTCTCCCAT	0.522													1	0	3.27435e-08	0.00245	3.39827e-08	12	101										T	130119513	G	T	130119513	3	4	19	1	0	0	0	0	1	0	0	0	6241	1290	45	3	2033	3	GARNL3	9	130119513	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2044687	130119513	11093918	267	5377										
NUP214	8021	broad.mit.edu	37	chr9	134026030	134026030	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actttcagaaggagttggaaGagttaaaagcccgaacttcc	10	8	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:134026030G>A	uc004cag.2	+	16	2266	c.2155G>A	c.(2155-2157)GAG>AAG	p.E719K	NUP214_uc004cah.2_Missense_Mutation_p.E709K|NUP214_uc004cai.2_Missense_Mutation_p.E149K|NUP214_uc004caf.1_Missense_Mutation_p.E708K|NUP214_uc010mzf.2_Missense_Mutation_p.E17K	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	719	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GGAGTTGGAAGAGTTAAAAGC	0.438			T	DEK|SET|ABL1	AML|T-ALL								0	0	0	0.004007	0	15	79										A	134026030	G	A	134026030	3	1	19	1	0	0	0	0	1	0	0	0	10762	943	33	1	2217	1	NUP214	9	134026030	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3906517	134026030	7187401	268	5378										
NUP214	8021	broad.mit.edu	37	chr9	134026095	134026095	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctgaggagatgaagatgctGcgaacagaatcagatgactt	12	6	2	7			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:134026095G>A	uc004cag.2	+	16	2331	c.2220G>A	c.(2218-2220)CTG>CTA	p.L740L	NUP214_uc004cah.2_Silent_p.L730L|NUP214_uc004cai.2_Silent_p.L170L|NUP214_uc004caf.1_Silent_p.L729L|NUP214_uc010mzf.2_Silent_p.L38L	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	740	Leucine-zipper 1.|11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGAAGATGCTGCGAACAGAAT	0.408			T	DEK|SET|ABL1	AML|T-ALL								0	0	0	0.009535	0	28	100										A	134026095	G	A	134026095	2	1	19	1	0	0	0	0	0	0	0	1	10762	1306	46	2		2	NUP214	9	134026095	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	65	134026095	7187336	269	5379										
SETX	23064	broad.mit.edu	37	chr9	135139634	135139634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cactgggctttcctataaaaGctttcttttcttggaactgc	7	10	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:135139634G>A	uc004cbk.2	-	26	8209	c.8026C>T	c.(8026-8028)CTT>TTT	p.L2676F	SETX_uc004cbj.2_Missense_Mutation_p.L2324F|SETX_uc010mzt.2_Missense_Mutation_p.L2262F	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2676	Necessary for nuclear localization.				cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCCTATAAAAGCTTTCTTTTC	0.493													0	0	0	0.01441	0	67	95										A	135139634	G	A	135139634	3	1	19	1	0	0	0	0	1	0	0	0	14141	971	34	2	11	2	SETX	9	135139634	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1113539	135139634	6073797	270	5380										
VAV2	7410	broad.mit.edu	37	chr9	136804268	136804268	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agaggtcaaaggggtcaaacAgctcgctgttccttaatcca	10	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:136804268A>G	uc004ces.2	-	2	324	c.278T>C	c.(277-279)CTG>CCG	p.L93P	VAV2_uc004cer.2_Missense_Mutation_p.L93P	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	93	CH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGGGTCAAACAGCTCGCTGTT	0.502													0	0	0	0.006999	0	40	57										G	136804268	A	G	136804268	3	3	19	1	0	0	0	0	1	0	0	0	17129	188	7	5	2474	5	VAV2	9	136804268	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	1664634	136804268	4409163	271	5381										
KIAA0649	9858	broad.mit.edu	37	chr9	138376899	138376899	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaaccggctcacggcagtgcCccgactgccctgtgtccccc	11	19	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:138376899C>T	uc004cfr.1	+	4	1092	c.543C>T	c.(541-543)GCC>GCT	p.A181A		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	181						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		ACGGCAGTGCCCCGACTGCCC	0.706													0	0	0	0.00245	0	13	48										T	138376899	C	T	138376899	2	4	19	1	0	0	0	0	0	0	0	1	8187	610	22	2		2	KIAA0649	9	138376899	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1572631	138376899	2836532	272	5382										
CAMSAP1	157922	broad.mit.edu	37	chr9	138713796	138713796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgagcttcaggcgctgccttGccgacagcgcctccatcttc	10	17	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:138713796G>A	uc004cgr.3	-	11	2711	c.2711C>T	c.(2710-2712)GCA>GTA	p.A904V	CAMSAP1_uc004cgq.3_Missense_Mutation_p.A794V|CAMSAP1_uc010nbg.2_Missense_Mutation_p.A626V	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	904						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GCGCTGCCTTGCCGACAGCGC	0.632													0	0	0	0.01441	0	41	76										A	138713796	G	A	138713796	3	1	19	1	0	0	0	0	1	0	0	0	2611	1319	46	2	2125	2	CAMSAP1	9	138713796	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	336897	138713796	2499635	273	5383										
MAN1B1	11253	broad.mit.edu	37	chr9	139981500	139981500	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagctctcggttcctctcagTcggacttcctgacgccgcca	10	16	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:139981500T>A	uc004cld.2	+	1	84	c.49T>A	c.(49-51)TCG>ACG	p.S17T	MAN1B1_uc004clc.2_5'UTR|MAN1B1_uc011meo.1_5'UTR|MAN1B1_uc011mep.1_Missense_Mutation_p.S17T|MAN1B1_uc010ncc.2_RNA|LOC100289341_uc004clb.3_5'Flank	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	17	Cytoplasmic (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		TTCCTCTCAGTCGGACTTCCT	0.692													0	0	0	0.013537	0	8	5										A	139981500	T	A	139981500	3	1	19	1	0	0	0	0	1	0	0	0	9212	1667	58	5	51	5	MAN1B1	9	139981500	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1267704	139981500	1231931	274	5384										
CACNA1B	774	broad.mit.edu	37	chr9	140878605	140878605	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcaggtcatcgtggggagcGtctttgaagtggtctgggcg	18	7	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:140878605G>A	uc004cog.2	+	13	1817	c.1672G>A	c.(1672-1674)GTC>ATC	p.V558I	CACNA1B_uc011mfd.1_Missense_Mutation_p.V89I	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	558	Helical; Name=S3 of repeat II; (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGTGGGGAGCGTCTTTGAAGT	0.592													0	0	0	0.000602	0	4	8										A	140878605	G	A	140878605	3	1	19	1	0	0	0	0	1	0	0	0	2539	1145	40	2	1722	2	CACNA1B	9	140878605	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	897105	140878605	334826	275	5385										
GPR158	57512	broad.mit.edu	37	chr10	25465209	25465209	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtggctggttactctttcctCtgccatctacgggttgcagc	11	12	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:25465209C>A	uc001isj.2	+	1	920	c.860C>A	c.(859-861)TCT>TAT	p.S287Y	LOC100128811_uc010qde.1_5'Flank	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	287	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ACTCTTTCCTCTGCCATCTAC	0.612													1	0	1.56738e-10	0.004289	1.64344e-10	28	22										A	25465209	C	A	25465209	3	1	19	1	0	0	0	0	1	0	0	0	6663	913	32	3	862	3	GPR158	10	25465209	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		25465209	110069538	276	5386										
ARMC4	55130	broad.mit.edu	37	chr10	28151397	28151397	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggacaataaaggaacaactCcatgatctgtgataacagct	8	8	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28151397C>A	uc009xky.2	-	18	2863	c.2765G>T	c.(2764-2766)GGA>GTA	p.G922V	ARMC4_uc010qds.1_Missense_Mutation_p.G447V|ARMC4_uc010qdt.1_Missense_Mutation_p.G614V|ARMC4_uc001itz.2_Missense_Mutation_p.G922V	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	922	ARM 8.						binding			ovary(4)|skin(2)	6						AGGAACAACTCCATGATCTGT	0.299													1	0	1.91123e-38	0.01441	2.08684e-38	62	61										A	28151397	C	A	28151397	3	1	19	1	0	0	0	0	1	0	0	0	953	855	30	3	381	3	ARMC4	10	28151397	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2686188	28151397	107383350	277	5387										
MPP7	143098	broad.mit.edu	37	chr10	28409311	28409311	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttatagtcaaagagggctttGataaacatctggaagaaaag	10	4	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28409311G>C	uc001iua.1	-	12	1103	c.699C>G	c.(697-699)ATC>ATG	p.I233M	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.I233M|MPP7_uc009xla.2_Missense_Mutation_p.I233M|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	233	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						AGAGGGCTTTGATAAACATCT	0.338													0	0	0	0.010818	0	31	36										C	28409311	G	C	28409311	3	2	19	1	0	0	0	0	1	0	0	0	9739	1280	45	1	1063	1	MPP7	10	28409311	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	257914	28409311	107125436	278	5388										
WAC	51322	broad.mit.edu	37	chr10	28897267	28897267	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgccaatacctcccttacttCaggacccaaatcttcttaga	4	15	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28897267C>T	uc001iuf.2	+	8	1157	c.1072C>T	c.(1072-1074)CAG>TAG	p.Q358*	WAC_uc001iud.2_Nonsense_Mutation_p.Q313*|WAC_uc001iue.2_Nonsense_Mutation_p.Q48*|WAC_uc009xlb.2_Nonsense_Mutation_p.Q313*|WAC_uc001iug.2_Nonsense_Mutation_p.Q255*|WAC_uc001iuh.2_Nonsense_Mutation_p.Q313*	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	358					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						TCCCTTACTTCAGGACCCAAA	0.458													0	0	0	0.001984	0	6	37										T	28897267	C	T	28897267	4	4	19	1	0	0	0	0	0	1	0	0	17244	827	29	1	1102	1	WAC	10	28897267	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	487956	28897267	106637480	279	5389										
TMEM72	643236	broad.mit.edu	37	chr10	45430144	45430144	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcctggcctacttccttctGagcaagcggaagaagaggaa	13	10	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:45430144G>C	uc001jbn.2	+	5	587	c.390G>C	c.(388-390)CTG>CTC	p.L130L	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Silent_p.L12L	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	130	Helical; (Potential).					integral to membrane					0						ACTTCCTTCTGAGCAAGCGGA	0.602													0	0	0	0.004007	0	16	148										C	45430144	G	C	45430144	2	2	19	1	0	0	0	0	0	0	0	1	16198	1277	45	1		1	TMEM72	10	45430144	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	16532877	45430144	90104603	280	5390										
FRMPD2	143162	broad.mit.edu	37	chr10	49393605	49393605	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agccctcttaccaaaaccacGatgtgggtcacgtttcagtg	9	12	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:49393605G>A	uc001jgi.2	-	18	2457	c.2350C>T	c.(2350-2352)CGT>TGT	p.R784C	FRMPD2_uc001jgh.2_Missense_Mutation_p.R752C|FRMPD2_uc001jgj.2_Missense_Mutation_p.R762C	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	784	PDZ 1.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CCAAAACCACGATGTGGGTCA	0.502													0	0	0	0.00333	0	19	111										A	49393605	G	A	49393605	3	1	19	1	0	0	0	0	1	0	0	0	6058	1058	37	1	1627	1	FRMPD2	10	49393605	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3963461	49393605	86141142	281	5391										
PCDH15	65217	broad.mit.edu	37	chr10	55826641	55826641	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctatgtttactgtggcagttGaggtcttaaagaaaaacaca	9	6	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:55826641G>C	uc001jju.1	-	18	2491	c.2096C>G	c.(2095-2097)TCA>TGA	p.S699*	PCDH15_uc010qhq.1_Nonsense_Mutation_p.S704*|PCDH15_uc010qhr.1_Nonsense_Mutation_p.S699*|PCDH15_uc010qhs.1_Nonsense_Mutation_p.S711*|PCDH15_uc010qht.1_Nonsense_Mutation_p.S706*|PCDH15_uc010qhu.1_Nonsense_Mutation_p.S699*|PCDH15_uc001jjv.1_Nonsense_Mutation_p.S677*|PCDH15_uc010qhv.1_Nonsense_Mutation_p.S699*|PCDH15_uc010qhw.1_Nonsense_Mutation_p.S662*|PCDH15_uc010qhx.1_Nonsense_Mutation_p.S628*|PCDH15_uc010qhy.1_Nonsense_Mutation_p.S704*|PCDH15_uc010qhz.1_Nonsense_Mutation_p.S699*|PCDH15_uc010qia.1_Nonsense_Mutation_p.S677*|PCDH15_uc010qib.1_Nonsense_Mutation_p.S677*|PCDH15_uc001jjw.2_Nonsense_Mutation_p.S699*	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	699	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTGGCAGTTGAGGTCTTAAA	0.368										HNSCC(58;0.16)			0	0	0	0.001984	0	6	89										C	55826641	G	C	55826641	4	2	19	1	0	0	0	0	0	1	0	0	11511	1294	45	1	5454	1	PCDH15	10	55826641	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	6433036	55826641	79708106	282	5392										
ARID5B	84159	broad.mit.edu	37	chr10	63852165	63852165	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcaggaaaacctcaccatgtGagactggagaatttcaggaa	10	8	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:63852165G>C	uc001jlt.1	+	10	2969	c.2943G>C	c.(2941-2943)GTG>GTC	p.V981V		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	981					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CTCACCATGTGAGACTGGAGA	0.537													0	0	0	0.013726	0	32	131										C	63852165	G	C	63852165	2	2	19	1	0	0	0	0	0	0	0	1	922	1277	45	1		1	ARID5B	10	63852165	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	8025524	63852165	71682582	283	5393										
STOX1	219736	broad.mit.edu	37	chr10	70645249	70645249	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggaagcagaatccatttacaTaaatgaccctactgtcaaac	6	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:70645249T>C	uc001jos.2	+	3	1784	c.1697T>C	c.(1696-1698)ATA>ACA	p.I566T	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.I456T	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	566						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						TCCATTTACATAAATGACCCT	0.418													0	0	0	0.003163	0	14	62										C	70645249	T	C	70645249	3	2	19	1	0	0	0	0	1	0	0	0	15318	1406	49	5	1707	5	STOX1	10	70645249	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	6793084	70645249	64889498	284	5394										
KIAA1279	26128	broad.mit.edu	37	chr10	70748916	70748916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgaaccacatcgacacggagGagctgtcggcgggggaggag	18	9	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:70748916G>A	uc001joy.2	+	1	424	c.328G>A	c.(328-330)GAG>AAG	p.E110K		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	110					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						CGACACGGAGGAGCTGTCGGC	0.682													0	0	0	0.00623	0	31	35										A	70748916	G	A	70748916	3	1	19	1	0	0	0	0	1	0	0	0	8221	1175	41	1	330	1	KIAA1279	10	70748916	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	103667	70748916	64785831	285	5395										
KIAA1274	27143	broad.mit.edu	37	chr10	72300935	72300935	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcttcgtgttcagctgcctCagcggccagggccgtaccac	13	15	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:72300935C>A	uc001jrd.3	+	16	2267	c.1986C>A	c.(1984-1986)CTC>CTA	p.L662L	KIAA1274_uc001jre.3_5'UTR	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	662										ovary(2)|central_nervous_system(1)	3						TCAGCTGCCTCAGCGGCCAGG	0.607													1	0	1.80625e-27	0.01441	1.96021e-27	62	67										A	72300935	C	A	72300935	2	1	19	1	0	0	0	0	0	0	0	1	8220	813	29	3		3	KIAA1274	10	72300935	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1552019	72300935	63233812	286	5396										
PSAP	5660	broad.mit.edu	37	chr10	73581638	73581638	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agtgacaccaggtaccttaaTgggctccaccagttccaggg	11	12	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:73581638T>C	uc001jsm.2	-	8	1008	c.904A>G	c.(904-906)ATT>GTT	p.I302V	PSAP_uc001jsl.2_Missense_Mutation_p.I26V	NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	302					glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						GGTACCTTAATGGGCTCCACC	0.408													0	0	0	0.013726	0	26	58										C	73581638	T	C	73581638	3	2	19	1	0	0	0	0	1	0	0	0	12643	1464	51	5	698	5	PSAP	10	73581638	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1280703	73581638	61953109	287	5397										
SYNPO2L	79933	broad.mit.edu	37	chr10	75406489	75406493	+	Frame_Shift_Del	DEL	GCCCC	GCCCC	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcctgttcactggtgccctGccccaggcctccacacatga							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:75406489_75406493delGCCCC	uc001jut.3	-	4	3069_3073	c.2917_2921delGGGGC	c.(2917-2922)GGGGCAfs	p.G973fs	SYNPO2L_uc001jus.3_Frame_Shift_Del_p.G749fs	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	973_974						cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					CTGGTGCCCTGCCCCAGGCCTCCAC	0.595																		35	169	---	---								-	75406493	GCCCC	-	75406489	7	5	19	1	0	1	0	1	0	0	0	0	15455	1319	46	0	16	0	SYNPO2L	10	75406489	Frame_Shift_Del	DEL	GCCCC	TCGA-BT-A3PJ-01A-21D-A21Z-08	1824851	75406489	60128258	288	5398										
GHITM	27069	broad.mit.edu	37	chr10	85903844	85903844	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggactgtctaatgagattgGagctattgaaaaggctgtgt	14	4	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:85903844G>A	uc001kcs.1	+	4	527	c.323G>A	c.(322-324)GGA>GAA	p.G108E	GHITM_uc010qma.1_Missense_Mutation_p.E64K|GHITM_uc010qmb.1_Missense_Mutation_p.G38E	NM_014394	NP_055209	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	108	Mitochondrial intermembrane (Potential).				apoptosis	integral to membrane|mitochondrial inner membrane					0						AATGAGATTGGAGCTATTGAA	0.398													0	0	0	0.01441	0	55	40										A	85903844	G	A	85903844	3	1	19	1	0	0	0	0	1	0	0	0	6370	1174	41	1	333	1	GHITM	10	85903844	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	10497355	85903844	49630903	289	5399										
PIK3AP1	118788	broad.mit.edu	37	chr10	98408463	98408463	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtccctgaagccgtgtttctCagcgatggtgttggggtagt	15	8	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:98408463C>G	uc001kmq.2	-	7	1266	c.1138G>C	c.(1138-1140)GAG>CAG	p.E380Q	PIK3AP1_uc001kmp.2_Missense_Mutation_p.E202Q	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	380						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CCGTGTTTCTCAGCGATGGTG	0.572													0	0	0	0.008361	0	25	23										G	98408463	C	G	98408463	3	3	19	1	0	0	0	0	1	0	0	0	11908	835	29	1	1323	1	PIK3AP1	10	98408463	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	12504619	98408463	37126284	290	5400										
RRP12	23223	broad.mit.edu	37	chr10	99160214	99160214	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	catgggcgtctccggggcttCgcttttgcccaagcgcaagg	14	13	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:99160214C>T	uc001knf.2	-	2	356	c.217G>A	c.(217-219)GAA>AAA	p.E73K	RRP12_uc010qou.1_Missense_Mutation_p.E73K|RRP12_uc009xvn.2_Missense_Mutation_p.E73K	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	73						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCCGGGGCTTCGCTTTTGCCC	0.562													0	0	0	0.01441	0	50	49										T	99160214	C	T	99160214	3	4	19	1	0	0	0	0	1	0	0	0	13686	893	31	1	3808	1	RRP12	10	99160214	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	751751	99160214	36374533	291	5401										
GSTO1	9446	broad.mit.edu	37	chr10	106022765	106022765	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttggtaggaagctttattaGaagccaaaataaagaagact	9	5	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:106022765G>A	uc001kya.2	+	4	404	c.395G>A	c.(394-396)AGA>AAA	p.R132K		NM_004832	NP_004823	P78417	GSTO1_HUMAN	glutathione-S-transferase omega 1	132	GST C-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	AGCTTTATTAGAAGCCAAAAT	0.368													0	0	0	0.001855	0	11	13										A	106022765	G	A	106022765	3	1	19	1	0	0	0	0	1	0	0	0	6842	942	33	1	409	1	GSTO1	10	106022765	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	6862551	106022765	29511982	292	5402										
GPAM	57678	broad.mit.edu	37	chr10	113928632	113928632	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccatggagcaaagctctataGagaacatctttccgtccatc	7	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:113928632G>C	uc009xxy.1	-	10	1071	c.873C>G	c.(871-873)CTC>CTG	p.L291L	GPAM_uc001kzp.2_Silent_p.L291L|GPAM_uc001kzq.1_Silent_p.L291L	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	291					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		AAGCTCTATAGAGAACATCTT	0.408													0	0	0	0.006999	0	31	30										C	113928632	G	C	113928632	2	2	19	1	0	0	0	0	0	0	0	1	6588	929	33	1		1	GPAM	10	113928632	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7905867	113928632	21606115	293	5403										
GPAM	57678	broad.mit.edu	37	chr10	113928680	113928680	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcatcgagccttcgtcgtatGaagaagcccccaagcttatg	9	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:113928680G>A	uc009xxy.1	-	10	1023	c.825C>T	c.(823-825)TTC>TTT	p.F275F	GPAM_uc001kzp.2_Silent_p.F275F|GPAM_uc001kzq.1_Silent_p.F275F	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	275					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		TTCGTCGTATGAAGAAGCCCC	0.373													0	0	0	0.004289	0	27	34										A	113928680	G	A	113928680	2	1	19	1	0	0	0	0	0	0	0	1	6588	1281	45	1		1	GPAM	10	113928680	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	48	113928680	21606067	294	5404										
FAM160B1	57700	broad.mit.edu	37	chr10	116621198	116621198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gttttttccttaccagtattGaccacatcacactgctagag	6	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:116621198G>A	uc001lcb.2	+	17	2532	c.2197G>A	c.(2197-2199)GAC>AAC	p.D733N	FAM160B1_uc001lcc.2_Intron	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	733										lung(1)	1						TACCAGTATTGACCACATCAC	0.368													0	0	0	0.004656	0	24	23										A	116621198	G	A	116621198	3	1	19	1	0	0	0	0	1	0	0	0	5470	1290	45	1	2263	1	FAM160B1	10	116621198	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2692518	116621198	18913549	295	5405										
TRUB1	142940	broad.mit.edu	37	chr10	116734976	116734976	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttcctgaagacaaatggacAattgatgacattgcacagtc	8	9	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:116734976A>T	uc001lcd.2	+	8	949	c.888A>T	c.(886-888)ACA>ACT	p.T296T	TRUB1_uc010qsl.1_Silent_p.T198T	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	296					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ACAAATGGACAATTGATGACA	0.433													0	0	0	0.01441	0	69	69										T	116734976	A	T	116734976	2	4	19	1	0	0	0	0	0	0	0	1	16599	117	5	5		5	TRUB1	10	116734976	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	113778	116734976	18799771	296	5406										
FAM45A	404636	broad.mit.edu	37	chr10	120892117	120892117	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaaatcagagagccacgttaTacaggtaactccctcacctt	7	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:120892117T>C	uc001ldw.2	+	8	937	c.893T>C	c.(892-894)ATA>ACA	p.I298T	FAM45A_uc010qsv.1_Missense_Mutation_p.I290T|FAM45A_uc010qsw.1_Missense_Mutation_p.I147T|FAM45A_uc010qsx.1_RNA|FAM45A_uc010qsy.1_Missense_Mutation_p.I225T|FAM45A_uc010qsz.1_Missense_Mutation_p.I187T	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	298										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		AGCCACGTTATACAGGTAACT	0.522													0	0	0	0.01441	0	113	54										C	120892117	T	C	120892117	3	2	19	1	0	0	0	0	1	0	0	0	5564	1406	49	5	923	5	FAM45A	10	120892117	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	4157141	120892117	14642630	297	5407										
ATE1	11101	broad.mit.edu	37	chr10	123658448	123658448	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggctgaaagacgacttgaActctgggtcctcaaaggaga	12	9	2	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:123658448A>G	uc001lfp.2	-	7	932	c.850T>C	c.(850-852)TTC>CTC	p.F284L	ATE1_uc001lfq.2_Intron|ATE1_uc010qtr.1_Intron|ATE1_uc010qts.1_Missense_Mutation_p.F188L|ATE1_uc010qtt.1_Missense_Mutation_p.F277L|ATE1_uc001lfr.2_Intron|ATE1_uc009xzu.2_Intron	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2	284					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				GACGACTTGAACTCTGGGTCC	0.438													0	0	0	0.01441	0	44	27										G	123658448	A	G	123658448	3	3	19	1	0	0	0	0	1	0	0	0	1078	43	2	5	730	5	ATE1	10	123658448	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2766331	123658448	11876299	298	5408										
TACC2	10579	broad.mit.edu	37	chr10	123844550	123844550	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acatccatctttgacgtgctCaaggagcaggcccagccacc	9	15	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:123844550C>G	uc001lfv.2	+	4	2895	c.2535C>G	c.(2533-2535)CTC>CTG	p.L845L	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.L845L|TACC2_uc010qtv.1_Silent_p.L845L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	845						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTGACGTGCTCAAGGAGCAGG	0.527													0	0	0	0.01441	0	103	66										G	123844550	C	G	123844550	2	3	19	1	0	0	0	0	0	0	0	1	15499	813	29	1		1	TACC2	10	123844550	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	186102	123844550	11690197	299	5409										
PPP2R2D	55844	broad.mit.edu	37	chr10	133757494	133757494	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cccaatattgaagcccatggAtcttatggtagaagcgagtc	10	9	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:133757494A>G	uc001lks.2	+	4	644	c.401A>G	c.(400-402)GAT>GGT	p.D134G	PPP2R2D_uc001lkr.2_Intron|PPP2R2D_uc001lkt.2_Intron|PPP2R2D_uc009yay.2_Missense_Mutation_p.D2G	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	167					cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		AAGCCCATGGATCTTATGGTA	0.343													0	0	0	0.00308	0	8	8										G	133757494	A	G	133757494	3	3	19	1	0	0	0	0	1	0	0	0	12387	333	12	5	416	5	PPP2R2D	10	133757494	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	9912944	133757494	1777253	300	5410										
SYCE1	93426	broad.mit.edu	37	chr10	135369290	135369290	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctccacatcttacactgtgGctgcagcctcctggctgcgg	10	16	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:135369290G>A	uc001lno.2	-	10	818	c.713C>T	c.(712-714)GCC>GTC	p.A238V	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.A110V|SYCE1_uc009ybn.2_Missense_Mutation_p.A238V|SYCE1_uc001lnn.2_Missense_Mutation_p.A202V	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	238	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTACACTGTGGCTGCAGCCTC	0.632													0	0	0	0.01441	0	52	32										A	135369290	G	A	135369290	3	1	19	1	0	0	0	0	1	0	0	0	15425	1203	42	2	401	2	SYCE1	10	135369290	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1611796	135369290	165457	301	5411										
FRG2B	441581	broad.mit.edu	37	chr10	135439041	135439041	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtctcctggatttcactgttGtgcacaggagtggaggatct	13	8	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:135439041G>T	uc010qvg.1	-	4	452	c.399C>A	c.(397-399)CAC>CAA	p.H133Q		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	133						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTTCACTGTTGTGCACAGGAG	0.532													1	0	1.90571e-15	0.004289	2.02499e-15	38	59										T	135439041	G	T	135439041	3	4	19	1	0	0	0	0	1	0	0	0	6047	1368	48	4	440	4	FRG2B	10	135439041	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	69751	135439041	95706	302	5412										
TRPM5	29850	broad.mit.edu	37	chr11	2432685	2432685	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccgtcatgggggtgcagcagCgcctgggtggtgacaccgta	17	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:2432685C>G	uc001lwm.3	-	18	2688	c.2679G>C	c.(2677-2679)GCG>GCC	p.A893A	TRPM5_uc010qxl.1_Silent_p.A893A|TRPM5_uc009ydn.2_Silent_p.A895A	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	893	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGTGCAGCAGCGCCTGGGTGG	0.632													0	0	0	0.009718	0	44	30										G	2432685	C	G	2432685	2	3	19	1	0	0	0	0	0	0	0	1	16586	755	27	4		4	TRPM5	11	2432685	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		2432685	132573831	303	5413										
OR6A2	8590	broad.mit.edu	37	chr11	6816047	6816047	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctctcttgacctcttgattgCgcaggcagtaaatgatggga	11	9	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:6816047C>T	uc001mes.1	-	1	1093	c.893G>A	c.(892-894)CGC>CAC	p.R298H		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTCTTGATTGCGCAGGCAGTA	0.488													0	0	0	0.003755	0	30	73										T	6816047	C	T	6816047	3	4	19	1	0	0	0	0	1	0	0	0	11186	768	27	2	94	2	OR6A2	11	6816047	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4383362	6816047	128190469	304	5414										
C11orf16	56673	broad.mit.edu	37	chr11	8947368	8947368	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccacatggcgggcagccacaGaggcagccctggcacagtag	14	14	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:8947368G>C	uc001mhb.3	-	5	970	c.846C>G	c.(844-846)CTC>CTG	p.L282L	C11orf16_uc001mhc.3_Silent_p.L282L	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	282										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GGCAGCCACAGAGGCAGCCCT	0.592													0	0	0	0.01441	0	88	78										C	8947368	G	C	8947368	2	2	19	1	0	0	0	0	0	0	0	1	1631	929	33	1		1	C11orf16	11	8947368	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2131321	8947368	126059148	305	5415										
IPO7	10527	broad.mit.edu	37	chr11	9435902	9435902	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcttctttctgaccagtctGatcagtctgtcctcatccag	7	13	6	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:9435902G>A	uc001mho.2	+	5	722	c.580G>A	c.(580-582)GAT>AAT	p.D194N		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	194					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGACCAGTCTGATCAGTCTGT	0.398													0	0	0	0.01441	0	66	68										A	9435902	G	A	9435902	3	1	19	1	0	0	0	0	1	0	0	0	7797	1290	45	1	598	1	IPO7	11	9435902	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	488534	9435902	125570614	306	5416										
PDE3B	5140	broad.mit.edu	37	chr11	14665990	14665990	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacagcttgagccccctcttCagcatcgcctgtgccttctt	7	17	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:14665990C>T	uc001mln.2	+	1	722	c.369C>T	c.(367-369)TTC>TTT	p.F123F	PDE3B_uc001mlm.2_Silent_p.F123F|PDE3B_uc010rcr.1_Silent_p.F123F|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	123	Helical; (Potential).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GCCCCCTCTTCAGCATCGCCT	0.716													0	0	0	0.00623	0	33	32										T	14665990	C	T	14665990	2	4	19	1	0	0	0	0	0	0	0	1	11638	825	29	1		1	PDE3B	11	14665990	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5230088	14665990	120340526	307	5417										
E2F8	79733	broad.mit.edu	37	chr11	19256466	19256466	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcggcgtacttattctcctcCccgatgctcttcaaggtgcc	8	15	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:19256466C>T	uc001mpm.2	-	5	1113	c.591G>A	c.(589-591)GGG>GGA	p.G197G	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Silent_p.G197G	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	197					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TATTCTCCTCCCCGATGCTCT	0.428													0	0	0	0.010504	0	15	86										T	19256466	C	T	19256466	2	4	19	1	0	0	0	0	0	0	0	1	4873	610	22	2		2	E2F8	11	19256466	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4590476	19256466	115750050	308	5418										
MADD	8567	broad.mit.edu	37	chr11	47350217	47350217	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtccggttttagttcctgaaAttaaagaagtggtgagccac	11	7	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:47350217A>G	uc001ner.1	+	35	4992	c.4801A>G	c.(4801-4803)ATT>GTT	p.I1601V	MADD_uc001neq.2_Missense_Mutation_p.I1542V|MADD_uc001nev.1_Silent_p.K1475K|MADD_uc001nes.1_Missense_Mutation_p.I1519V|MADD_uc001net.1_Missense_Mutation_p.I1562V|MADD_uc009yln.1_Missense_Mutation_p.I1495V|MADD_uc001neu.1_Missense_Mutation_p.I1499V|MADD_uc001nex.2_Silent_p.K1577K|MADD_uc001nez.2_Missense_Mutation_p.I1498V|MADD_uc001new.2_Missense_Mutation_p.I1541V	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1601					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		AGTTCCTGAAATTAAAGAAGT	0.577													0	0	0	0.003163	0	13	43										G	47350217	A	G	47350217	3	3	19	1	0	0	0	0	1	0	0	0	9152	101	4	5	4935	5	MADD	11	47350217	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	28093751	47350217	87656299	309	5419										
OR9G4	283189	broad.mit.edu	37	chr11	56510978	56510978	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agccaaggaaatgcgcttatCttctgagacacaactggcca	9	11	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:56510978C>T	uc010rjo.1	-	1	310	c.310G>A	c.(310-312)GAT>AAT	p.D104N		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	104	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATGCGCTTATCTTCTGAGACA	0.458													0	0	0	0.01441	0	57	77										T	56510978	C	T	56510978	3	4	19	1	0	0	0	0	1	0	0	0	11251	913	32	1	676	1	OR9G4	11	56510978	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9160761	56510978	78495538	310	5420										
MRPL16	54948	broad.mit.edu	37	chr11	59578113	59578113	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caggagcggcgcactagcgcGagccagcagcctccacatgg	14	15	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:59578113G>A	uc001noh.2	-	1	233	c.19C>T	c.(19-21)CGC>TGC	p.R7C		NM_017840	NP_060310	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16 precursor	7							rRNA binding			central_nervous_system(1)	1						GCACTAGCGCGAGCCAGCAGC	0.652													0	0	0	0.01441	0	45	80										A	59578113	G	A	59578113	3	1	19	1	0	0	0	0	1	0	0	0	9781	1058	37	1	752	1	MRPL16	11	59578113	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3067135	59578113	75428403	311	5421										
MS4A4A	51338	broad.mit.edu	37	chr11	60070049	60070049	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taggtccgaggtagtctaggAatgaatatcaccagctctgt	11	8	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:60070049A>G	uc001noz.2	+	5	415	c.405A>G	c.(403-405)GGA>GGG	p.G135G	MS4A4A_uc001npa.2_Silent_p.G116G|MS4A4A_uc001npb.2_Silent_p.G116G|MS4A4A_uc001npc.2_Intron	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	135	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GTAGTCTAGGAATGAATATCA	0.303													0	0	0	0.004007	0	14	69										G	60070049	A	G	60070049	2	3	19	1	0	0	0	0	0	0	0	1	9862	233	9	5		5	MS4A4A	11	60070049	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	491936	60070049	74936467	312	5422										
DDB1	1642	broad.mit.edu	37	chr11	61099151	61099151	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acaggtttaagtcttcggccGaagtaaagtgtcctgaaaga	11	7	1	2	rs35597036		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61099151G>A	uc001nrc.3	-	2	300	c.74C>T	c.(73-75)TCG>TTG	p.S25L	DDB1_uc010rle.1_Missense_Mutation_p.S25L|DDB1_uc010rlf.1_Missense_Mutation_p.S25L|DDB1_uc001nrd.2_Missense_Mutation_p.S25L|DDB1_uc009ynl.1_Missense_Mutation_p.S25L|DAK_uc001nre.2_5'Flank	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	25	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						GTCTTCGGCCGAAGTAAAGTG	0.468								NER					0	0	0	0.003954	0	19	70										A	61099151	G	A	61099151	3	1	19	1	0	0	0	0	1	0	0	0	4323	1059	37	1	3452	1	DDB1	11	61099151	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1029102	61099151	73907365	313	5423										
FADS1	3992	broad.mit.edu	37	chr11	61570834	61570834	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttctgagtgactgtcccttaCctgggtggaaacccagtcca	10	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61570834C>T	uc010rlm.1	-	9	1376	c.1248_splice	c.e9+1	p.Q416_splice	FADS1_uc001nsh.2_Splice_Site_p.Q275_splice	NM_013402	NP_037534	O60427	FADS1_HUMAN	fatty acid desaturase 1						cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)	1					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTGTCCCTTACCTGGGTGGAA	0.458													0	0	0	0.01441	0	78	196										T	61570834	C	T	61570834	5	4	19	1	0	0	0	0	0	0	1	0	5365	521	18	2	272	2	FADS1	11	61570834	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	471683	61570834	73435682	314	5424										
FADS1	3992	broad.mit.edu	37	chr11	61580784	61580784	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggagagagttcatatacttCttcacaaggcccttgttgat	9	8	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61580784C>T	uc010rlm.1	-	2	545	c.417G>A	c.(415-417)AAG>AAA	p.K139K	FADS2_uc001nsj.2_5'Flank|FADS1_uc001nsh.2_5'UTR|FADS1_uc010rln.1_5'UTR	NM_013402	NP_037534	O60427	FADS1_HUMAN	fatty acid desaturase 1	82	Cytoplasmic (Potential).|Cytochrome b5 heme-binding.				cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)	1					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCATATACTTCTTCACAAGGC	0.532													0	0	0	0.01441	0	103	154										T	61580784	C	T	61580784	2	4	19	1	0	0	0	0	0	0	0	1	5365	912	32	1		1	FADS1	11	61580784	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9950	61580784	73425732	315	5425										
EML3	256364	broad.mit.edu	37	chr11	62376050	62376050	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agggccccaacaccccgctcGaaggcccccagtccaatctc	8	20	1	0	rs138198368		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62376050G>A	uc001ntu.1	-	9	1382	c.1074C>T	c.(1072-1074)TTC>TTT	p.F358F	EML3_uc001ntr.1_Silent_p.F330F|EML3_uc001nts.1_Silent_p.F330F|EML3_uc001ntt.1_Silent_p.F242F|EML3_uc010rly.1_Silent_p.F358F|EML3_uc009yny.1_Silent_p.F141F	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	358	WD 2.					cytoplasm|microtubule	protein binding			ovary(1)	1						CACCCCGCTCGAAGGCCCCCA	0.597													0	0	0	0.01441	0	51	348										A	62376050	G	A	62376050	2	1	19	1	0	0	0	0	0	0	0	1	5098	1049	37	1		1	EML3	11	62376050	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	795266	62376050	72630466	316	5426										
TAF6L	10629	broad.mit.edu	37	chr11	62554200	62554200	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gccggaggacccttctctttCggtgaccctggccgacatct	11	15	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62554200C>T	uc001nvc.2	+	11	1402	c.1301C>T	c.(1300-1302)TCG>TTG	p.S434L	TMEM179B_uc001nvd.3_5'Flank	NM_006473	NP_006464	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II	434					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			ovary(3)	3						CCTTCTCTTTCGGTGACCCTG	0.692											OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008361	0	25	45										T	62554200	C	T	62554200	3	4	19	1	0	0	0	0	1	0	0	0	15528	893	31	1	1339	1	TAF6L	11	62554200	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	178150	62554200	72452316	317	5427										
SLC22A8	9376	broad.mit.edu	37	chr11	62760793	62760793	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctggctcctgctttggcttCtttgcccgcagggacctagg	12	13	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62760793C>G	uc001nwo.2	-	11	1681	c.1545G>C	c.(1543-1545)AAG>AAC	p.K515N	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_3'UTR|SLC22A8_uc009yom.2_Missense_Mutation_p.K392N|SLC22A8_uc010rmm.1_Missense_Mutation_p.K424N|SLC22A8_uc009yon.2_Missense_Mutation_p.K515N	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	515	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GCTTTGGCTTCTTTGCCCGCA	0.632													0	0	0	0.010729	0	10	28										G	62760793	C	G	62760793	3	3	19	1	0	0	0	0	1	0	0	0	14460	912	32	1	87	1	SLC22A8	11	62760793	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	206593	62760793	72245723	318	5428										
MARK2	2011	broad.mit.edu	37	chr11	63666130	63666130	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaacgctctaccttgtcatgGagtacgctagtggcggtagg	13	9	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:63666130G>A	uc001nxw.2	+	5	967	c.388G>A	c.(388-390)GAG>AAG	p.E130K	MARK2_uc001nxx.2_Missense_Mutation_p.E130K|MARK2_uc001nxy.2_Missense_Mutation_p.E130K|MARK2_uc001nxv.3_Missense_Mutation_p.E130K|MARK2_uc001nxz.3_Missense_Mutation_p.E97K|MARK2_uc009yoy.2_Missense_Mutation_p.E97K	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCTTGTCATGGAGTACGCTAG	0.498													0	0	0	0.01441	0	47	121										A	63666130	G	A	63666130	3	1	19	1	0	0	0	0	1	0	0	0	9313	1175	41	1	406	1	MARK2	11	63666130	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	905337	63666130	71340386	319	5429										
PLCB3	5331	broad.mit.edu	37	chr11	64030227	64030227	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agtaccgcacccggacctctCaggggaactcgttcaacccc	9	17	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:64030227C>T	uc001nzb.2	+	19	2302	c.2302C>T	c.(2302-2304)CAG>TAG	p.Q768*	PLCB3_uc009ypg.1_Nonsense_Mutation_p.Q768*|PLCB3_uc009yph.1_Nonsense_Mutation_p.Q701*|PLCB3_uc009ypi.2_Nonsense_Mutation_p.Q768*	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	768	C2.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCGGACCTCTCAGGGGAACTC	0.637													0	0	0	0.01441	0	165	227										T	64030227	C	T	64030227	4	4	19	1	0	0	0	0	0	1	0	0	12029	827	29	1	2376	1	PLCB3	11	64030227	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	364097	64030227	70976289	320	5430										
CAPN1	823	broad.mit.edu	37	chr11	64972254	64972254	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggctgcagcttcgtgctcgcCcttatgcagaagcaccgtcg	12	14	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:64972254C>G	uc009yqd.1	+	11	1377	c.1266C>G	c.(1264-1266)GCC>GCG	p.A422A	CAPN1_uc001odf.1_Silent_p.A422A|CAPN1_uc001odg.1_Silent_p.A422A|CAPN1_uc010roa.1_Silent_p.A163A	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	422	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TCGTGCTCGCCCTTATGCAGA	0.637											OREG0021073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009718	0	39	84										G	64972254	C	G	64972254	2	3	19	1	0	0	0	0	0	0	0	1	2622	610	22	4		4	CAPN1	11	64972254	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	942027	64972254	70034262	321	5431										
KCNK7	10089	broad.mit.edu	37	chr11	65363055	65363055	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcagtgcccagcagctcttcCagagctccgggtggcaggca	14	14	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:65363055C>A	uc001oes.2	-	1	413	c.189G>T	c.(187-189)CTG>CTT	p.L63L	KCNK7_uc001oeq.2_Silent_p.L63L|KCNK7_uc001oer.2_Silent_p.L63L|KCNK7_uc001oeu.2_Silent_p.L63L	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	63						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						GCAGCTCTTCCAGAGCTCCGG	0.687													1	0	0.000157383	0.00308	0.000160996	8	7										A	65363055	C	A	65363055	2	1	19	1	0	0	0	0	0	0	0	1	8071	581	21	4		4	KCNK7	11	65363055	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	390801	65363055	69643461	322	5432										
SLC29A2	3177	broad.mit.edu	37	chr11	66134033	66134033	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actactgggaatcccgttctCatctggggtgaggggggacg	16	9	2	1	rs141666252		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:66134033C>T	uc001oht.2	-	8	965	c.736G>A	c.(736-738)GAG>AAG	p.E246K	SLC29A2_uc001ohs.2_Missense_Mutation_p.E126K|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Missense_Mutation_p.E126K|SLC29A2_uc001ohu.2_Missense_Mutation_p.E246K|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	246					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						ATCCCGTTCTCATCTGGGGTG	0.577													0	0	0	0.012213	0	25	66										T	66134033	C	T	66134033	3	4	19	1	0	0	0	0	1	0	0	0	14535	835	29	1	654	1	SLC29A2	11	66134033	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	770978	66134033	68872483	323	5433										
INPPL1	3636	broad.mit.edu	37	chr11	71949115	71949115	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgcagggcgggcgggccagCgggctgggcgaggcaggcat	22	11	0	0	rs34634942		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:71949115C>T	uc001osf.2	+	27	3729	c.3582C>T	c.(3580-3582)AGC>AGT	p.S1194S	INPPL1_uc001osg.2_Silent_p.S952S	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1194					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						GGCGGGCCAGCGGGCTGGGCG	0.652											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	10	53										T	71949115	C	T	71949115	2	4	19	1	0	0	0	0	0	0	0	1	7761	767	27	2		2	INPPL1	11	71949115	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5815082	71949115	63057401	324	5434										
ARHGEF17	9828	broad.mit.edu	37	chr11	73066682	73066682	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaggcgaggcctgcctttctCaagttcctagaggtactgtg	13	10	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:73066682C>G	uc001otu.2	+	4	3579	c.3558C>G	c.(3556-3558)CTC>CTG	p.L1186L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1186	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CTGCCTTTCTCAAGTTCCTAG	0.557													0	0	0	0.01441	0	34	88										G	73066682	C	G	73066682	2	3	19	1	0	0	0	0	0	0	0	1	900	813	29	1		1	ARHGEF17	11	73066682	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1117567	73066682	61939834	325	5435										
MYO7A	4647	broad.mit.edu	37	chr11	76903243	76903243	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcacgccctggcacagccccTccgaggacaacgtggccacc	10	19	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:76903243T>A	uc001oyb.2	+	31	4344	c.4072T>A	c.(4072-4074)TCC>ACC	p.S1358T	MYO7A_uc010rsm.1_Missense_Mutation_p.S1347T|MYO7A_uc001oyc.2_Missense_Mutation_p.S1358T|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.S569T	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1358	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCACAGCCCCTCCGAGGACAA	0.622											OREG0021258	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	79	107										A	76903243	T	A	76903243	3	1	19	1	0	0	0	0	1	0	0	0	10082	1551	54	5	4224	5	MYO7A	11	76903243	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	3836561	76903243	58103273	326	5436										
SYTL2	54843	broad.mit.edu	37	chr11	85456690	85456690	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tttgccttacctcgggcttgCtggtgctgcatcttcttctg	10	12	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:85456690C>T	uc010rth.1	-	3	655	c.379G>A	c.(379-381)GCA>ACA	p.A127T	SYTL2_uc010rtg.1_Missense_Mutation_p.A127T|SYTL2_uc010rti.1_Missense_Mutation_p.A127T|SYTL2_uc010rtj.1_Missense_Mutation_p.A79T|SYTL2_uc001pbf.3_Missense_Mutation_p.A127T	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	127					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTCGGGCTTGCTGGTGCTGCA	0.532													0	0	0	0.01441	0	78	192										T	85456690	C	T	85456690	3	4	19	1	0	0	0	0	1	0	0	0	15480	797	28	2	4973	2	SYTL2	11	85456690	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8553447	85456690	49549826	327	5437										
TYR	7299	broad.mit.edu	37	chr11	88911234	88911234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggagaaggaatgctgtccacCgtggagcggggacaggagtc	18	8	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:88911234C>T	uc001pcs.2	+	1	195	c.113C>T	c.(112-114)CCG>CTG	p.P38L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	38	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TGCTGTCCACCGTGGAGCGGG	0.547									Oculocutaneous_Albinism				0	0	0	0.01441	0	48	50										T	88911234	C	T	88911234	3	4	19	1	0	0	0	0	1	0	0	0	16810	652	23	2	115	2	TYR	11	88911234	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3454544	88911234	46095282	328	5438										
GPR83	10888	broad.mit.edu	37	chr11	94134384	94134384	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtggctcgcaccaaggggagGagacagagcagcaagaggtg	18	8	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:94134384G>T	uc001pet.2	-	1	202	c.30C>A	c.(28-30)CTC>CTA	p.L10L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	10						integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCAAGGGGAGGAGACAGAGCA	0.711													1	0	2.94398e-08	0.007413	3.06432e-08	18	46										T	94134384	G	T	94134384	2	4	19	1	0	0	0	0	0	0	0	1	6713	1161	41	3		3	GPR83	11	94134384	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5223150	94134384	40872132	329	5439										
KDM4DL	390245	broad.mit.edu	37	chr11	94759441	94759441	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggctgtgaggccttcctgcgGcacaaagtggccctcatctc	12	14	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:94759441G>C	uc010ruf.1	+	1	1020	c.720G>C	c.(718-720)CGG>CGC	p.R240R		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	240	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CCTTCCTGCGGCACAAAGTGG	0.562													0	0	0	0.006122	0	17	20										C	94759441	G	C	94759441	2	2	19	1	0	0	0	0	0	0	0	1	8132	1190	42	4		4	KDM4DL	11	94759441	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	625057	94759441	40247075	330	5440										
CWF19L2	143884	broad.mit.edu	37	chr11	107205622	107205622	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttacagactttctgatatcTtttgaagagagatctatcaa	6	7	4	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:107205622T>A	uc010rvp.1	-	16	2454	c.2424A>T	c.(2422-2424)AAA>AAT	p.K808N	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	808							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TTCTGATATCTTTTGAAGAGA	0.338													0	0	0	0.003163	0	12	77										A	107205622	T	A	107205622	3	1	19	1	0	0	0	0	1	0	0	0	4072	1606	56	5	272	5	CWF19L2	11	107205622	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	12446181	107205622	27800894	331	5441										
KDELC2	143888	broad.mit.edu	37	chr11	108357021	108357021	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcatccccaaaccttttggGgacttcttttagcatttgct	6	12	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:108357021G>A	uc001pkj.2	-	3	613	c.547C>T	c.(547-549)CCC>TCC	p.P183S	KDELC2_uc001pki.2_Missense_Mutation_p.P127S	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	183						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		AACCTTTTGGGGACTTCTTTT	0.423													0	0	0	0.01441	0	67	76										A	108357021	G	A	108357021	3	1	19	1	0	0	0	0	1	0	0	0	8118	1232	43	2	1000	2	KDELC2	11	108357021	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1151399	108357021	26649495	332	5442										
ARHGAP20	57569	broad.mit.edu	37	chr11	110582896	110582897	+	Frame_Shift_Ins	INS	-	-	A													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccgagacactcctgtcagggINSaagaggagcgccccggctgt							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:110582896_110582897insA	uc001pkz.1	-	2	343_344	c.58_59insT	c.(58-60)TCCfs	p.S20fs	ARHGAP20_uc001pky.1_5'Flank|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	20					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCTGTCAGGGAAGAGGAGCGC	0.48																		19	34	---	---								A	110582897	-	A	110582896	7	5	19	1	0	1	1	0	0	0	0	0	870	1174	41	0	3576	0	ARHGAP20	11	110582896	Frame_Shift_Ins	INS	-	TCGA-BT-A3PJ-01A-21D-A21Z-08	2225875	110582896	24423620	333	5443										
PCSK7	9159	broad.mit.edu	37	chr11	117089803	117089803	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcacgagcctccaggcgttGaggaggccgaaaccgtgctg	14	12	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:117089803G>C	uc001pqr.2	-	11	1602	c.1401C>G	c.(1399-1401)CTC>CTG	p.L467L		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	467	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		TCCAGGCGTTGAGGAGGCCGA	0.602			T	IGH@	MLCLS								0	0	0	0.009535	0	25	17										C	117089803	G	C	117089803	2	2	19	1	0	0	0	0	0	0	0	1	11605	1277	45	1		1	PCSK7	11	117089803	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	6506907	117089803	17916713	334	5444										
DSCAML1	57453	broad.mit.edu	37	chr11	117392001	117392001	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcgtcaggcagcaccagctCcgtgttgcgataccagcgga	12	14	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:117392001C>T	uc001prh.1	-	6	1239	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	DSCAML1_uc001pri.1_Missense_Mutation_p.E217K	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	353	Extracellular (Potential).|Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGCACCAGCTCCGTGTTGCGA	0.627													0	0	0	0.01441	0	100	81										T	117392001	C	T	117392001	3	4	19	1	0	0	0	0	1	0	0	0	4769	864	30	1	5216	1	DSCAML1	11	117392001	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	302198	117392001	17614515	335	5445										
VPS11	55823	broad.mit.edu	37	chr11	118948319	118948319	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggcggagaaccatgcacatCatgagtggtacctgaagatc	12	9	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:118948319C>T	uc010ryx.1	+	10	1576	c.1534C>T	c.(1534-1536)CAT>TAT	p.H512Y	VPS11_uc010ryy.1_Missense_Mutation_p.H358Y	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	512	Clathrin.				protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CCATGCACATCATGAGTGGTA	0.393													0	0	0	0.004482	0	8	14										T	118948319	C	T	118948319	3	4	19	1	0	0	0	0	1	0	0	0	17185	826	29	1	1567	1	VPS11	11	118948319	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1556318	118948319	16058197	336	5446										
H2AFX	3014	broad.mit.edu	37	chr11	118965872	118965872	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcaggtggcgggggatgattCgcgtcttcttgttgtcgcgg	18	8	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:118965872C>T	uc001pvg.2	-	1	306	c.233G>A	c.(232-234)CGA>CAA	p.R78Q	H2AFX_uc001pvh.1_RNA	NM_002105	NP_002096	P16104	H2AX_HUMAN	H2A histone family, member X	78				R -> L (in Ref. 2; CAG33360).	DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		GGGGATGATTCGCGTCTTCTT	0.682								Chromatin_Structure|Direct_reversal_of_damage			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	38	225										T	118965872	C	T	118965872	3	4	19	1	0	0	0	0	1	0	0	0	6928	884	31	1	202	1	H2AFX	11	118965872	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	17553	118965872	16040644	337	5447										
MCAM	4162	broad.mit.edu	37	chr11	119181614	119181614	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cggctccggcagctttctctCtgcgccacaaagacactcct	8	17	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119181614C>T	uc001pwf.2	-	14	1675	c.1646_splice	c.e14-1	p.E549_splice	MCAM_uc001pwg.1_Splice_Site	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule						anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		AGCTTTCTCTCTGCGCCACAA	0.632													0	0	0	0.007835	0	34	182										T	119181614	C	T	119181614	5	4	19	1	0	0	0	0	0	0	1	0	9368	927	32	1	307	1	MCAM	11	119181614	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	215742	119181614	15824902	338	5448										
MCAM	4162	broad.mit.edu	37	chr11	119182861	119182861	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctctcaggggctgcgggactCactcggacgtcagacacatc	12	14	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119182861C>T	uc001pwf.2	-	9	1073	c.1044G>A	c.(1042-1044)GTG>GTA	p.V348V	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	348	Ig-like C2-type 2.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CTGCGGGACTCACTCGGACGT	0.627													0	0	0	0.00499	0	15	93										T	119182861	C	T	119182861	2	4	19	1	0	0	0	0	0	0	0	1	9368	813	29	1		1	MCAM	11	119182861	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1247	119182861	15823655	339	5449										
MCAM	4162	broad.mit.edu	37	chr11	119183625	119183625	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcaaggtgtacaaaccactCgactccacagtctgggacga	10	12	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119183625C>G	uc001pwf.2	-	6	623	c.594G>C	c.(592-594)TCG>TCC	p.S198S	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	198	Ig-like V-type 2.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		ACAAACCACTCGACTCCACAG	0.562													0	0	0	0.008871	0	18	94										G	119183625	C	G	119183625	2	3	19	1	0	0	0	0	0	0	0	1	9368	871	31	1		1	MCAM	11	119183625	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	764	119183625	15822891	340	5450										
PANX3	116337	broad.mit.edu	37	chr11	124489817	124489817	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acctcaccaactcggcatgtGatgaacacccatagttaaga	7	12	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:124489817G>C	uc001qah.2	+	4	1165	c.1165G>C	c.(1165-1167)GAT>CAT	p.D389H	TBRG1_uc001qak.3_5'Flank|TBRG1_uc001qaj.3_5'Flank|TBRG1_uc001qal.3_5'Flank|TBRG1_uc001qam.3_5'Flank|TBRG1_uc009zbf.2_5'Flank|TBRG1_uc009zbg.2_5'Flank|TBRG1_uc001qai.1_5'Flank	NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	389	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTCGGCATGTGATGAACACCC	0.418													0	0	0	0.006999	0	34	47										C	124489817	G	C	124489817	3	2	19	1	0	0	0	0	1	0	0	0	11422	1290	45	1	1179	1	PANX3	11	124489817	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5306192	124489817	10516699	341	5451										
PKNOX2	63876	broad.mit.edu	37	chr11	125280125	125280125	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attcccccaattccatgtccGgagtctccaataacccccag	5	17	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:125280125G>C	uc001qbu.2	+	8	936	c.622G>C	c.(622-624)GGA>CGA	p.G208R	PKNOX2_uc010saz.1_Missense_Mutation_p.G179R|PKNOX2_uc010sba.1_Missense_Mutation_p.G179R|PKNOX2_uc010sbb.1_Missense_Mutation_p.G144R|PKNOX2_uc001qbv.2_5'Flank	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	208						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		TTCCATGTCCGGAGTCTCCAA	0.572													0	0	0	0.01441	0	108	217										C	125280125	G	C	125280125	3	2	19	1	0	0	0	0	1	0	0	0	11983	1117	39	4	640	4	PKNOX2	11	125280125	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	790308	125280125	9726391	342	5452										
JAM3	83700	broad.mit.edu	37	chr11	134010623	134010623	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcgagtggaagaaaattcaaGatgaacaaaccacatatgtg	9	6	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:134010623G>A	uc001qhb.1	+	3	373	c.349G>A	c.(349-351)GAT>AAT	p.D117N	JAM3_uc009zcz.1_Missense_Mutation_p.D117N	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	72	Extracellular (Potential).|Ig-like V-type.				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		GAAAATTCAAGATGAACAAAC	0.438													0	0	0	0.00308	0	6	58										A	134010623	G	A	134010623	3	1	19	1	0	0	0	0	1	0	0	0	7944	942	33	1	359	1	JAM3	11	134010623	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	8730498	134010623	995893	343	5453										
GLB1L2	89944	broad.mit.edu	37	chr11	134238561	134238561	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttttgaaaaccgtgtctgccAttgtggacgccggctcctcc	10	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:134238561A>G	uc001qhp.2	+	10	1101	c.913A>G	c.(913-915)ATT>GTT	p.I305V	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	305					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CGTGTCTGCCATTGTGGACGC	0.532													0	0	0	0.001855	0	12	72										G	134238561	A	G	134238561	3	3	19	1	0	0	0	0	1	0	0	0	6429	217	8	5	951	5	GLB1L2	11	134238561	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	227938	134238561	767955	344	5454										
IQSEC3	440073	broad.mit.edu	37	chr12	284199	284199	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggctcaaggagcctggtgtaGactctgccccaccaccctgc	11	16	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:284199G>C	uc001qhw.1	+	11	2646	c.2640G>C	c.(2638-2640)TAG>TAC	p.*880Y		NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	880	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GCCTGGTGTAGACTCTGCCCC	0.692													0	0	0	0.006122	0	16	15										C	284199	G	C	284199	4	2	19	1	0	0	0	0	0	0	0	0	7819	937	33	1	3682	1	IQSEC3	12	284199	Nonstop_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		284199	133567696	345	5455										
WNK1	65125	broad.mit.edu	37	chr12	862795	862795	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccctgttcctctcgccgccgGctcctgcccccaagaatggc	9	20	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:862795G>T	uc001qio.3	+	1	571	c.64G>T	c.(64-66)GCT>TCT	p.A22S	WNK1_uc001qin.2_Missense_Mutation_p.A22S|WNK1_uc001qip.3_Missense_Mutation_p.A22S	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	22					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTCGCCGCCGGCTCCTGCCCC	0.682													1	0	1.10923e-09	0.00278	1.15626e-09	20	37										T	862795	G	T	862795	3	4	19	1	0	0	0	0	1	0	0	0	17374	1203	42	4	66	4	WNK1	12	862795	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	578596	862795	132989100	346	5456										
NRIP2	83714	broad.mit.edu	37	chr12	2944040	2944040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gccaggggctgctcggtgggGgcgtcaccgagtcctctctg	17	13	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:2944040G>A	uc001qlc.2	-	1	182	c.110C>T	c.(109-111)CCC>CTC	p.P37L	NRIP2_uc010sed.1_Missense_Mutation_p.P37L|uc009zdz.1_5'Flank	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	37					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GCTCGGTGGGGGCGTCACCGA	0.632													0	0	0	0.011902	0	44	94										A	2944040	G	A	2944040	3	1	19	1	0	0	0	0	1	0	0	0	10653	1232	43	2	759	2	NRIP2	12	2944040	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2081245	2944040	130907855	347	5457										
C1S	716	broad.mit.edu	37	chr12	7175803	7175803	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggagctgggtgaatgaggtGctgggcccggagctgccgaa	20	8	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:7175803G>A	uc001qsj.2	+	14	1958	c.1239G>A	c.(1237-1239)GTG>GTA	p.V413V	C1S_uc001qsk.2_Silent_p.V413V|C1S_uc001qsl.2_Silent_p.V413V|C1S_uc009zfr.2_Silent_p.V246V|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	413	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TGAATGAGGTGCTGGGCCCGG	0.552													0	0	0	0.01441	0	44	106										A	7175803	G	A	7175803	2	1	19	1	0	0	0	0	0	0	0	1	1974	1306	46	2		2	C1S	12	7175803	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4231763	7175803	126676092	348	5458										
A2M	2	broad.mit.edu	37	chr12	9242527	9242527	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagaggcttgatgactgtgtCtttccttccgtgttcaggaa	11	9	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:9242527C>G	uc001qvk.1	-	21	2802	c.2689G>C	c.(2689-2691)GAC>CAC	p.D897H	A2M_uc009zgk.1_Missense_Mutation_p.D747H	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	897					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGACTGTGTCTTTCCTTCCG	0.368													0	0	0	0.00499	0	16	42										G	9242527	C	G	9242527	3	3	19	1	0	0	0	0	1	0	0	0	4	913	32	1	1799	1	A2M	12	9242527	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2066724	9242527	124609368	349	5459										
KLRD1	3824	broad.mit.edu	37	chr12	10464092	10464100	+	In_Frame_Del	DEL	TGGGTTGGG	TGGGTTGGG	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctgttcttgccaagaaaaaTgggttgggtaccggtgcaac							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:10464092_10464100delTGGGTTGGG	uc001qxw.3	+	5	390_398	c.193_201delTGGGTTGGG	c.(193-201)TGGGTTGGGdel	p.WVG65del	KLRD1_uc001qxx.3_In_Frame_Del_p.WVG65del|KLRD1_uc001qxy.3_In_Frame_Del_p.WVG34del|KLRD1_uc009zhh.2_In_Frame_Del_p.WVG44del|KLRD1_uc009zhi.2_In_Frame_Del_p.WVG65del|KLRD1_uc001qxz.3_In_Frame_Del_p.WVG65del	NM_001114396	NP_001107868	Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D,	65_67	Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						CCAAGAAAAATGGGTTGGGTACCGGTGCA	0.402																		15	101	---	---								-	10464100	TGGGTTGGG	-	10464092	7	5	19	1	0	1	0	1	0	0	0	0	8419	1464	51	0	207	0	KLRD1	12	10464092	In_Frame_Del	DEL	TGGGTTGGG	TCGA-BT-A3PJ-01A-21D-A21Z-08	1221565	10464092	123387803	350	5460										
MANSC1	54682	broad.mit.edu	37	chr12	12483694	12483694	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctgggcacttgcttcatccAtcttaaatagtttctccaag	7	11	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:12483694A>G	uc001rai.1	-	4	821	c.563T>C	c.(562-564)ATG>ACG	p.M188T	MANSC1_uc010shm.1_Missense_Mutation_p.M122T|MANSC1_uc001raj.1_Missense_Mutation_p.M154T|MANSC1_uc009zht.1_Missense_Mutation_p.M107T	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	188	Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TGCTTCATCCATCTTAAATAG	0.418													0	0	0	0.004656	0	21	38										G	12483694	A	G	12483694	3	3	19	1	0	0	0	0	1	0	0	0	9224	217	8	5	736	5	MANSC1	12	12483694	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2019602	12483694	121368201	351	5461										
SLCO1A2	6579	broad.mit.edu	37	chr12	21453315	21453315	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atatttttccttcttgacctCttctttttgtttgtcttcat	3	9	5	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:21453315C>T	uc001rer.2	-	7	1128	c.877G>A	c.(877-879)GAG>AAG	p.E293K	SLCO1A2_uc001res.2_Missense_Mutation_p.E293K|SLCO1A2_uc010siq.1_Missense_Mutation_p.E161K|SLCO1A2_uc010sio.1_Missense_Mutation_p.E161K|SLCO1A2_uc010sip.1_Missense_Mutation_p.E161K|SLCO1A2_uc001ret.2_Missense_Mutation_p.E291K|SLCO1A2_uc001reu.2_Missense_Mutation_p.E273K	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	293	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TTCTTGACCTCTTCTTTTTGT	0.299													0	0	0	0.009096	0	3	15										T	21453315	C	T	21453315	3	4	19	1	0	0	0	0	1	0	0	0	14722	922	32	1	1167	1	SLCO1A2	12	21453315	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	8969621	21453315	112398580	352	5462										
SLCO1A2	6579	broad.mit.edu	37	chr12	21453473	21453473	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	accaccatgcaccgacccaaCgagtgtcagtgggagttatg	11	12	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:21453473C>T	uc001rer.2	-	7	970	c.719G>A	c.(718-720)CGT>CAT	p.R240H	SLCO1A2_uc001res.2_Missense_Mutation_p.R240H|SLCO1A2_uc010siq.1_Missense_Mutation_p.R108H|SLCO1A2_uc010sio.1_Missense_Mutation_p.R108H|SLCO1A2_uc010sip.1_Missense_Mutation_p.R108H|SLCO1A2_uc001ret.2_Missense_Mutation_p.R238H|SLCO1A2_uc001reu.2_Missense_Mutation_p.R220H	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	240	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACCGACCCAACGAGTGTCAGT	0.383													0	0	0	0.004672	0	3	25										T	21453473	C	T	21453473	3	4	19	1	0	0	0	0	1	0	0	0	14722	536	19	2	1325	2	SLCO1A2	12	21453473	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	158	21453473	112398422	353	5463										
STK38L	23012	broad.mit.edu	37	chr12	27470859	27470859	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tttctgctctgaaacacctcAagaaacgtacagaaaagtga	7	9	3	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:27470859A>G	uc001rhr.2	+	11	1185	c.986A>G	c.(985-987)CAA>CGA	p.Q329R	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.Q236R|STK38L_uc010sjn.1_Missense_Mutation_p.Q67R|STK38L_uc010sjo.1_5'UTR	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	329	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					GAAACACCTCAAGAAACGTAC	0.383													0	0	0	0.013537	0	11	21										G	27470859	A	G	27470859	3	3	19	1	0	0	0	0	1	0	0	0	15303	130	5	5	1024	5	STK38L	12	27470859	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	6017386	27470859	106381036	354	5464										
DENND5B	160518	broad.mit.edu	37	chr12	31632937	31632937	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagggaagttgtatctccttCatcaagactacttgccaatg	8	9	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:31632937C>A	uc001rki.1	-	3	676	c.490G>T	c.(490-492)GAA>TAA	p.E164*	DENND5B_uc001rkh.1_Nonsense_Mutation_p.E199*|DENND5B_uc009zjq.1_Nonsense_Mutation_p.E83*|DENND5B_uc001rkj.2_Nonsense_Mutation_p.E186*|DENND5B_uc001rkk.1_Nonsense_Mutation_p.E86*	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	164						integral to membrane				ovary(1)|central_nervous_system(1)	2						GTATCTCCTTCATCAAGACTA	0.423													1	0	1.76056e-25	0.011902	1.90193e-25	40	79										A	31632937	C	A	31632937	4	1	19	1	0	0	0	0	0	1	0	0	4437	835	29	3	3410	3	DENND5B	12	31632937	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4162078	31632937	102218958	355	5465										
MLL2	8085	broad.mit.edu	37	chr12	49443747	49443747	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcaccctggctcagattagaGatctcgttaacgatgtcgga	10	10	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49443747G>C	uc001rta.3	-	11	3624	c.3624C>G	c.(3622-3624)ATC>ATG	p.I1208M		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1208					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAGATTAGAGATCTCGTTAA	0.607			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004656	0	26	43										C	49443747	G	C	49443747	3	2	19	1	0	0	0	0	1	0	0	0	9621	932	33	1	13165	1	MLL2	12	49443747	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	17810810	49443747	84408148	356	5466										
LMBR1L	55716	broad.mit.edu	37	chr12	49494208	49494208	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acaggaagtgctgagcttagGaccaggagacagacacagtt	13	8	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49494208G>A	uc001rth.3	-	15	1545	c.1203C>T	c.(1201-1203)GTC>GTT	p.V401V	LMBR1L_uc001rtg.3_Silent_p.V396V|LMBR1L_uc001rti.3_Silent_p.V381V	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	401	Helical; (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1						CTGAGCTTAGGACCAGGAGAC	0.453													0	0	0	0.01441	0	49	105										A	49494208	G	A	49494208	2	1	19	1	0	0	0	0	0	0	0	1	8841	1161	41	1		1	LMBR1L	12	49494208	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	50461	49494208	84357687	357	5467										
TROAP	10024	broad.mit.edu	37	chr12	49724323	49724323	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgctgtaggagtgagcctgaGataccggagtcctctcgcca	13	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49724323G>T	uc001rtx.3	+	13	1862	c.1695G>T	c.(1693-1695)GAG>GAT	p.E565D	TROAP_uc009zlh.2_Missense_Mutation_p.E565D|TROAP_uc001rty.2_Missense_Mutation_p.E273D	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	565	4 X 33 AA approximate tandem repeats.|Cys-rich.|2.				cell adhesion	cytoplasm				ovary(1)	1						GTGAGCCTGAGATACCGGAGT	0.592													1	0	4.14922e-12	0.004007	4.37632e-12	15	56										T	49724323	G	T	49724323	3	4	19	1	0	0	0	0	1	0	0	0	16572	933	33	3	1843	3	TROAP	12	49724323	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	230115	49724323	84127572	358	5468										
NCKAP5L	57701	broad.mit.edu	37	chr12	50189089	50189089	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggccgtggtactaccacagtCtgcccagggagggcccttcc	13	15	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50189089C>T	uc009zlk.2	-	8	2756	c.2554G>A	c.(2554-2556)GAC>AAC	p.D852N	NCKAP5L_uc001rvc.3_Missense_Mutation_p.D56N|NCKAP5L_uc001rvb.2_Missense_Mutation_p.D445N	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	848	Pro-rich.									central_nervous_system(1)	1						CTACCACAGTCTGCCCAGGGA	0.647													0	0	0	0.00623	0	32	146										T	50189089	C	T	50189089	3	4	19	1	0	0	0	0	1	0	0	0	10224	913	32	1	1474	1	NCKAP5L	12	50189089	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	464766	50189089	83662806	359	5469										
LIMA1	51474	broad.mit.edu	37	chr12	50615999	50615999	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttaagatcctcaccgtccttGatgtggggatatcgaccctg	10	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50615999G>C	uc001rwj.3	-	4	609	c.435C>G	c.(433-435)ATC>ATG	p.I145M	LIMA1_uc001rwh.3_Translation_Start_Site|LIMA1_uc001rwi.3_Translation_Start_Site|LIMA1_uc001rwk.3_Missense_Mutation_p.I145M|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	145					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CACCGTCCTTGATGTGGGGAT	0.453													0	0	0	0.010729	0	11	53										C	50615999	G	C	50615999	3	2	19	1	0	0	0	0	1	0	0	0	8796	1280	45	1	1879	1	LIMA1	12	50615999	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	426910	50615999	83235896	360	5470										
LIMA1	51474	broad.mit.edu	37	chr12	50616215	50616215	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctgggttctcccacttcttCtttaacacagtcagggtccc	7	15	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50616215C>T	uc001rwj.3	-	4	393	c.219G>A	c.(217-219)AAG>AAA	p.K73K	LIMA1_uc001rwh.3_5'UTR|LIMA1_uc001rwi.3_5'UTR|LIMA1_uc001rwk.3_Silent_p.K73K|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	73					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CCCACTTCTTCTTTAACACAG	0.498													0	0	0	0.01441	0	58	89										T	50616215	C	T	50616215	2	4	19	1	0	0	0	0	0	0	0	1	8796	912	32	1		1	LIMA1	12	50616215	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	216	50616215	83235680	361	5471										
ATF1	466	broad.mit.edu	37	chr12	51207891	51207891	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgacaaattcaggcagtactCagcaaggtacaactattctt	7	9	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:51207891C>T	uc001rww.3	+	5	705	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	ATF1_uc010smu.1_Nonsense_Mutation_p.Q8*	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	143					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						AGGCAGTACTCAGCAAGGTAC	0.468			T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								0	0	0	0.001855	0	14	63										T	51207891	C	T	51207891	4	4	19	1	0	0	0	0	0	1	0	0	1079	827	29	1	441	1	ATF1	12	51207891	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	591676	51207891	82644004	362	5472										
NCKAP1L	3071	broad.mit.edu	37	chr12	54920519	54920519	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaacagacaatcaccacactCtacacaaactggtcagtgtt	6	12	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:54920519C>T	uc001sgc.3	+	21	2443	c.2364C>T	c.(2362-2364)CTC>CTT	p.L788L	NCKAP1L_uc010sox.1_Silent_p.L330L|NCKAP1L_uc010soy.1_Silent_p.L738L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	788					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TCACCACACTCTACACAAACT	0.512													0	0	0	0.004007	0	15	20										T	54920519	C	T	54920519	2	4	19	1	0	0	0	0	0	0	0	1	10222	900	32	1		1	NCKAP1L	12	54920519	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3712628	54920519	78931376	363	5473										
STAT2	6773	broad.mit.edu	37	chr12	56749506	56749506	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctcaccaattgggccctctGagcctggatcaaaattcttt	7	13	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:56749506G>A	uc001slc.2	-	4	445	c.367C>T	c.(367-369)CAG>TAG	p.Q123*	STAT2_uc001sld.2_Nonsense_Mutation_p.Q119*|STAT2_uc010sqn.1_Nonsense_Mutation_p.Q119*	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	123					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGGGCCCTCTGAGCCTGGATC	0.453													0	0	0	0.01441	0	44	74										A	56749506	G	A	56749506	4	1	19	1	0	0	0	0	0	1	0	0	15264	1299	45	1	2272	1	STAT2	12	56749506	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1828987	56749506	77102389	364	5474										
STAC3	246329	broad.mit.edu	37	chr12	57638146	57638146	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgactgtgatcttctctccTggcctgggaggggaagggag	16	8	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:57638146T>A	uc001snp.2	-	10	1005	c.810A>T	c.(808-810)CCA>CCT	p.P270P	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Silent_p.P231P|STAC3_uc010srm.1_Silent_p.P84P	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	270	SH3 1.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TCTTCTCTCCTGGCCTGGGAG	0.587											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	19	71										A	57638146	T	A	57638146	2	1	19	1	0	0	0	0	0	0	0	1	15240	1567	55	5		5	STAC3	12	57638146	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	888640	57638146	76213749	365	5475										
C12orf56	115749	broad.mit.edu	37	chr12	64784273	64784273	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtcgtagacctcgggcggcaGatgccgccgcaggaacacat	14	13	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:64784273G>T	uc001ssa.3	-	1	73	c.73C>A	c.(73-75)CTG>ATG	p.L25M	uc001srx.2_Intron	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	25											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		TCGGGCGGCAGATGCCGCCGC	0.682													1	0	9.65021e-13	0.010818	1.01935e-12	29	46										T	64784273	G	T	64784273	3	4	19	1	0	0	0	0	1	0	0	0	1700	933	33	3	1847	3	C12orf56	12	64784273	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7146127	64784273	69067622	366	5476										
IRAK3	11213	broad.mit.edu	37	chr12	66605248	66605248	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atactgcttaaatcttccatCagctttcaaaatatcataga	3	9	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:66605248C>G	uc001sth.2	+	5	561	c.459C>G	c.(457-459)ATC>ATG	p.I153M	IRAK3_uc010ssy.1_Missense_Mutation_p.I92M	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	153					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		AATCTTCCATCAGCTTTCAAA	0.343													0	0	0	0.010729	0	10	14										G	66605248	C	G	66605248	3	3	19	1	0	0	0	0	1	0	0	0	7824	816	29	1	477	1	IRAK3	12	66605248	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1820975	66605248	67246647	367	5477										
CAND1	55832	broad.mit.edu	37	chr12	67696105	67696119	+	In_Frame_Del	DEL	AGTGATGATGAATAC	AGTGATGATGAATAC	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attaaaacttacccttagggAgtgatgatgaatacagtgat							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:67696105_67696119delAGTGATGATGAATAC	uc001stn.2	+	8	1440_1454	c.1003_1017delAGTGATGATGAATAC	c.(1003-1017)AGTGATGATGAATACdel	p.SDDEY335del	CAND1_uc001sto.2_In_Frame_Del_p.SDDEY13del	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	335_339	Asp-rich.|HEAT 8.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		ACCCTTAGGGAGTGATGATGAATACAGTGATGATG	0.358																		10	179	---	---								-	67696119	AGTGATGATGAATAC	-	67696105	7	5	19	1	0	1	0	1	0	0	0	0	2615	304	11	0	1033	0	CAND1	12	67696105	In_Frame_Del	DEL	AGTGATGATGAATAC	TCGA-BT-A3PJ-01A-21D-A21Z-08	1090857	67696105	66155790	368	5478										
FRS2	10818	broad.mit.edu	37	chr12	69968139	69968139	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggtgtatgaaaatataaatGggctatctatccctagtgcc	9	7	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:69968139G>A	uc001suy.2	+	10	1441	c.931G>A	c.(931-933)GGG>AGG	p.G311R	FRS2_uc001suz.2_Missense_Mutation_p.G311R|FRS2_uc009zrj.2_Missense_Mutation_p.G311R|FRS2_uc009zrk.2_Missense_Mutation_p.G311R	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	311					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAATATAAATGGGCTATCTAT	0.458													0	0	0	0.007291	0	28	48										A	69968139	G	A	69968139	3	1	19	1	0	0	0	0	1	0	0	0	6061	1348	47	2	949	2	FRS2	12	69968139	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2272034	69968139	63883756	369	5479										
C12orf12	196477	broad.mit.edu	37	chr12	91347544	91347544	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctctccctcctccacatattCagcctcttcgacctcttctt	2	19	5	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:91347544C>T	uc001tbj.2	-	1	1410	c.976G>A	c.(976-978)GAA>AAA	p.E326K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	326	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						tccacatattcagcctcttcg	0.164													0	0	0	0.008291	0	10	23										T	91347544	C	T	91347544	3	4	19	1	0	0	0	0	1	0	0	0	1676	835	29	1	248	1	C12orf12	12	91347544	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	21379405	91347544	42504351	370	5480										
CHST11	50515	broad.mit.edu	37	chr12	105151459	105151459	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agtctacgagaactactgatGaaatgaccacagaattcttc	7	9	2	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:105151459G>A	uc001tkx.1	+	4	1228	c.937G>A	c.(937-939)GAA>AAA	p.E313K	CHST11_uc001tky.2_Missense_Mutation_p.E308K|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	313	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						AACTACTGATGAAATGACCAC	0.463													0	0	0	0.001855	0	12	30										A	105151459	G	A	105151459	3	1	19	1	0	0	0	0	1	0	0	0	3399	1291	45	1	947	1	CHST11	12	105151459	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	13803915	105151459	28700436	371	5481										
FOXN4	121643	broad.mit.edu	37	chr12	109719382	109719382	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggtctgggctggtgctggaGagtctggagcaagatgtgcc	19	7	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:109719382G>C	uc001toe.3	-	9	1229	c.1124C>G	c.(1123-1125)TCT>TGT	p.S375C	FOXN4_uc009zvg.2_Missense_Mutation_p.S172C|FOXN4_uc001tof.3_Missense_Mutation_p.S195C	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	375					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						TGGTGCTGGAGAGTCTGGAGC	0.682													0	0	0	0.008291	0	10	22										C	109719382	G	C	109719382	3	2	19	1	0	0	0	0	1	0	0	0	6022	942	33	1	437	1	FOXN4	12	109719382	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4567923	109719382	24132513	372	5482										
UBE3B	89910	broad.mit.edu	37	chr12	109940905	109940905	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcgggggtaaacgggtcgacTctgcagaagtccagaaggtt	15	8	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:109940905T>A	uc001top.2	+	14	1963	c.1360T>A	c.(1360-1362)TCT>ACT	p.S454T	UBE3B_uc001toq.2_Missense_Mutation_p.S454T|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.S454T	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	454					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						ACGGGTCGACTCTGCAGAAGT	0.512													0	0	0	0.008871	0	19	87										A	109940905	T	A	109940905	3	1	19	1	0	0	0	0	1	0	0	0	16877	1551	54	5	1406	5	UBE3B	12	109940905	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	221523	109940905	23910990	373	5483										
BRAP	8315	broad.mit.edu	37	chr12	112087755	112087755	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atacctactttctttccacaGactgcttttcttttaggaga	5	10	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:112087755G>A	uc001tsn.3	-	11	1597	c.1403C>T	c.(1402-1404)TCT>TTT	p.S468F	BRAP_uc010syh.1_Missense_Mutation_p.S289F|BRAP_uc009zvv.2_Missense_Mutation_p.S438F	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	468	Potential.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						TCTTTCCACAGACTGCTTTTC	0.338													0	0	0	0.009096	0	3	38										A	112087755	G	A	112087755	3	1	19	1	0	0	0	0	1	0	0	0	1497	942	33	1	383	1	BRAP	12	112087755	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2146850	112087755	21764140	374	5484										
SRRM4	84530	broad.mit.edu	37	chr12	119583320	119583320	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccacgcaaaccagctcagcCaggtctcggggccaggagaa	12	14	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:119583320C>T	uc001txa.1	+	9	1198	c.906C>T	c.(904-906)GCC>GCT	p.A302A		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	302	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CCAGCTCAGCCAGGTCTCGGG	0.622													0	0	0	0.001168	0	3	17										T	119583320	C	T	119583320	2	4	19	1	0	0	0	0	0	0	0	1	15170	581	21	2		2	SRRM4	12	119583320	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	7495565	119583320	14268575	375	5485										
COQ5	84274	broad.mit.edu	37	chr12	120947870	120947870	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaaggcaatggtgtaaatatCaaacttgtcatcatcaaagg	8	6	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:120947870C>G	uc001tyn.2	-	4	651	c.631G>C	c.(631-633)GAT>CAT	p.D211H	COQ5_uc001tyo.2_Missense_Mutation_p.D130H|COQ5_uc010szj.1_Missense_Mutation_p.D137H	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	211					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGTAAATATCAAACTTGTCA	0.448													0	0	0	0.01441	0	38	59										G	120947870	C	G	120947870	3	3	19	1	0	0	0	0	1	0	0	0	3748	826	29	1	368	1	COQ5	12	120947870	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1364550	120947870	12904025	376	5486										
P2RX7	5027	broad.mit.edu	37	chr12	121615184	121615184	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atccctggtgcaagtgctgtCagccctgtgtggtcaacgaa	12	11	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:121615184C>T	uc001tzm.2	+	11	1219	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	P2RX7_uc001tzn.2_Nonsense_Mutation_p.Q285*|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_Nonsense_Mutation_p.Q86*|P2RX7_uc001tzq.2_Nonsense_Mutation_p.Q205*	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	375						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAAGTGCTGTCAGCCCTGTGT	0.532													0	0	0	0.00245	0	13	58										T	121615184	C	T	121615184	4	4	19	1	0	0	0	0	0	1	0	0	11345	827	29	1	1165	1	P2RX7	12	121615184	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	667314	121615184	12236711	377	5487										
KDM2B	84678	broad.mit.edu	37	chr12	121878735	121878735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aactggagctgcaaagggccGagaccgcgatccatgagcag	14	11	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:121878735G>A	uc001uat.2	-	21	3598	c.3494C>T	c.(3493-3495)TCG>TTG	p.S1165L	KDM2B_uc001uaq.2_Missense_Mutation_p.S605L|KDM2B_uc010szy.1_Missense_Mutation_p.S605L|KDM2B_uc001uar.2_Missense_Mutation_p.S756L|KDM2B_uc001uas.2_Missense_Mutation_p.S1096L|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.S413L|KDM2B_uc010szx.1_Missense_Mutation_p.S413L|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1165	LRR 3.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						GCAAAGGGCCGAGACCGCGAT	0.637													0	0	0	0.00623	0	28	87										A	121878735	G	A	121878735	3	1	19	1	0	0	0	0	1	0	0	0	8125	1059	37	1	580	1	KDM2B	12	121878735	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	263551	121878735	11973160	378	5488										
RSRC2	65117	broad.mit.edu	37	chr12	122991412	122991412	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcaatttcctaaatttgacaTtttggtccttgtttccaaaa	4	8	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:122991412T>C	uc001ucr.2	-	9	1240	c.1094A>G	c.(1093-1095)AAT>AGT	p.N365S	RSRC2_uc001uco.2_Missense_Mutation_p.N134S|RSRC2_uc001ucp.2_Missense_Mutation_p.N306S|RSRC2_uc001ucq.2_Missense_Mutation_p.N133S|RSRC2_uc001ucs.2_Missense_Mutation_p.N134S|RSRC2_uc001uct.2_Missense_Mutation_p.N317S|RSRC2_uc001ucu.2_Missense_Mutation_p.N366S	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	365										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		AAATTTGACATTTTGGTCCTT	0.289													0	0	0	0.006999	0	34	51										C	122991412	T	C	122991412	3	2	19	1	0	0	0	0	1	0	0	0	13715	1493	52	5	218	5	RSRC2	12	122991412	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1112677	122991412	10860483	379	5489										
ABCB9	23457	broad.mit.edu	37	chr12	123434347	123434347	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggaccaacctgtgcggttctCatcaaagaagcttgtctcct	9	12	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:123434347C>T	uc001udm.3	-	4	1145	c.835G>A	c.(835-837)GAG>AAG	p.E279K	ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.E279K|ABCB9_uc010taj.1_Missense_Mutation_p.E279K|ABCB9_uc001udp.2_Missense_Mutation_p.E279K|ABCB9_uc001udq.2_Missense_Mutation_p.E61K|ABCB9_uc001udr.2_Missense_Mutation_p.E279K	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	279	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GTGCGGTTCTCATCAAAGAAG	0.572													0	0	0	0.005443	0	23	74										T	123434347	C	T	123434347	3	4	19	1	0	0	0	0	1	0	0	0	48	835	29	1	1501	1	ABCB9	12	123434347	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	442935	123434347	10417548	380	5490										
DNAH10	196385	broad.mit.edu	37	chr12	124330151	124330151	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgtgcgttttctgcagagtcGactggatgctcctgtaccag	12	10	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:124330151G>A	uc001uft.3	+	30	5036	c.5011G>A	c.(5011-5013)GAC>AAC	p.D1671N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1671	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGCAGAGTCGACTGGATGCT	0.532													0	0	0	0.013726	0	25	32										A	124330151	G	A	124330151	3	1	19	1	0	0	0	0	1	0	0	0	4598	1058	37	1	5129	1	DNAH10	12	124330151	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	895804	124330151	9521744	381	5491										
DNAH10	196385	broad.mit.edu	37	chr12	124345611	124345611	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	accccaaagccgtgagtgtcAtagaactctacggcatcctg	9	13	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:124345611A>G	uc001uft.3	+	38	6473	c.6448A>G	c.(6448-6450)ATA>GTA	p.I2150V		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2150	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CGTGAGTGTCATAGAACTCTA	0.483													0	0	0	0.010818	0	27	32										G	124345611	A	G	124345611	3	3	19	1	0	0	0	0	1	0	0	0	4598	217	8	5	6598	5	DNAH10	12	124345611	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	15460	124345611	9506284	382	5492										
TMEM132B	114795	broad.mit.edu	37	chr12	125834468	125834468	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggaagtggcagccagctgtCggctgcaaggggccccaggg	19	11	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:125834468C>T	uc001uhe.1	+	2	531	c.523C>T	c.(523-525)CGG>TGG	p.R175W		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	175	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCCAGCTGTCGGCTGCAAGG	0.612													0	0	0	0.009718	0	35	49										T	125834468	C	T	125834468	3	4	19	1	0	0	0	0	1	0	0	0	16043	875	31	1	529	1	TMEM132B	12	125834468	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1488857	125834468	8017427	383	5493										
GOLGA3	2802	broad.mit.edu	37	chr12	133384936	133384936	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccagagaccggattttgcttGatttggaagtttttttctcc	9	8	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:133384936G>C	uc001ukz.1	-	5	1278	c.719C>G	c.(718-720)TCA>TGA	p.S240*	GOLGA3_uc001ula.1_Nonsense_Mutation_p.S240*|GOLGA3_uc001ulb.2_Nonsense_Mutation_p.S240*	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	240	Golgi-targeting domain.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GATTTTGCTTGATTTGGAAGT	0.532													0	0	0	0.01441	0	89	126										C	133384936	G	C	133384936	4	2	19	1	0	0	0	0	0	1	0	0	6554	1294	45	1	3995	1	GOLGA3	12	133384936	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7550468	133384936	466959	384	5494										
EFHA1	221154	broad.mit.edu	37	chr13	22178097	22178097	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctgtgcggagactgtaaaaCtgccatcccgcgccgcaaca	10	15	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:22178097C>G	uc001uof.2	-	1	213	c.191G>C	c.(190-192)AGT>ACT	p.S64T		NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	64							calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		GACTGTAAAACTGCCATCCCG	0.672													0	0	0	0.00632	0	18	98										G	22178097	C	G	22178097	3	3	19	1	0	0	0	0	1	0	0	0	4943	565	20	4	1161	4	EFHA1	13	22178097	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		22178097	92991781	385	5495										
MIPEP	4285	broad.mit.edu	37	chr13	24449002	24449002	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taccttttctttgtctagatGgattccactaatttcaaaat	4	8	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:24449002G>A	uc001uox.3	-	5	686	c.586C>T	c.(586-588)CAT>TAT	p.H196Y		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	196					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		TTGTCTAGATGGATTCCACTA	0.323													0	0	0	0.010818	0	27	109										A	24449002	G	A	24449002	3	1	19	1	0	0	0	0	1	0	0	0	9592	1348	47	2	1615	2	MIPEP	13	24449002	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2270905	24449002	90720876	386	5496										
POLR1D	51082	broad.mit.edu	37	chr13	28197305	28197305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaatgagctcatgaatgtctGccaacatgtgcttgacaagt	10	8	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:28197305G>A	uc010tdm.1	+	3	1350	c.320G>A	c.(319-321)TGC>TAC	p.C107Y	LNX2_uc001url.3_5'Flank|LNX2_uc001urm.1_5'Flank|POLR1D_uc010aam.2_Intron|POLR1D_uc001urq.2_Intron|POLR1D_uc001uro.2_Missense_Mutation_p.C107Y|POLR1D_uc001urp.2_Intron	NM_015972	NP_057056	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D isoform 1	107					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		ATGAATGTCTGCCAACATGTG	0.423													0	0	0	0.011902	0	37	95										A	28197305	G	A	28197305	3	1	19	1	0	0	0	0	1	0	0	0	12212	1319	46	2	326	2	POLR1D	13	28197305	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3748303	28197305	86972573	387	5497										
KL	9365	broad.mit.edu	37	chr13	33638310	33638310	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctactcgaagaaaggcagaaGaagttacaaatagttctgaa	9	6	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:33638310G>A	uc001uus.2	+	5	3034	c.3026G>A	c.(3025-3027)AGA>AAA	p.R1009K		NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	1009	Cytoplasmic (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		AAAGGCAGAAGAAGTTACAAA	0.323													0	0	0	0.010729	0	10	25										A	33638310	G	A	33638310	3	1	19	1	0	0	0	0	1	0	0	0	8331	942	33	1	3044	1	KL	13	33638310	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5441005	33638310	81531568	388	5498										
RFXAP	5994	broad.mit.edu	37	chr13	37394043	37394043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagaagagcgaccaggccctGaactgcggtgggactgcctc	14	12	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:37394043G>A	uc001uvu.1	+	1	705	c.549G>A	c.(547-549)CTG>CTA	p.L183L		NM_000538	NP_000529	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	183						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ACCAGGCCCTGAACTGCGGTG	0.557													0	0	0	0.012319	0	18	18										A	37394043	G	A	37394043	2	1	19	1	0	0	0	0	0	0	0	1	13270	1277	45	1		1	RFXAP	13	37394043	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3755733	37394043	77775835	389	5499										
NHLRC3	387921	broad.mit.edu	37	chr13	39621833	39621833	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttactcctgatgggaagtacTtgattgtggcccagctgaat	11	8	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:39621833T>C	uc001uxc.2	+	7	1136	c.814T>C	c.(814-816)TTG>CTG	p.L272L	NHLRC3_uc001uxd.2_Silent_p.L205L|NHLRC3_uc001uxe.2_Silent_p.L75L	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	272						extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TGGGAAGTACTTGATTGTGGC	0.423													0	0	0	0.004656	0	23	16										C	39621833	T	C	39621833	2	2	19	1	0	0	0	0	0	0	0	1	10407	1606	56	5		5	NHLRC3	13	39621833	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	2227790	39621833	75548045	390	5500										
AKAP11	11215	broad.mit.edu	37	chr13	42876628	42876628	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctacttttttaaacccctCagacgaaaatttgaaaacat	4	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:42876628C>T	uc001uys.1	+	8	3921	c.3746C>T	c.(3745-3747)TCA>TTA	p.S1249L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1249					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTAAACCCCTCAGACGAAAAT	0.363													0	0	0	0.013726	0	28	32										T	42876628	C	T	42876628	3	4	19	1	0	0	0	0	1	0	0	0	447	838	29	1	3768	1	AKAP11	13	42876628	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3254795	42876628	72293250	391	5501										
AKAP11	11215	broad.mit.edu	37	chr13	42877371	42877371	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttgaaaaatctggatatgaaGaagataatgagtgtcacgtt	10	3	2	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:42877371G>A	uc001uys.1	+	8	4664	c.4489G>A	c.(4489-4491)GAA>AAA	p.E1497K		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1497					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGGATATGAAGAAGATAATGA	0.398													0	0	0	0.01441	0	42	40										A	42877371	G	A	42877371	3	1	19	1	0	0	0	0	1	0	0	0	447	943	33	1	4511	1	AKAP11	13	42877371	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	743	42877371	72292507	392	5502										
RB1	5925	broad.mit.edu	37	chr13	48937042	48937043	+	Frame_Shift_Ins	INS	-	-	A													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caaaacaactagaaaatgatINSacaagaattattgaagttct							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:48937042_48937043insA	uc001vcb.2	+	8	976_977	c.810_811insA	c.(808-813)GATACAfs	p.D270fs	RB1_uc010acs.1_RNA|RB1_uc010act.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	270_271					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.L267fs*3(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAGAAAATGATACAAGAATTAT	0.342		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)								40	49	---	---								A	48937043	-	A	48937042	7	5	19	1	0	1	1	0	0	0	0	0	13098	1403	49	0	840	0	RB1	13	48937042	Frame_Shift_Ins	INS	-	TCGA-BT-A3PJ-01A-21D-A21Z-08	6059671	48937042	66232836	393	5503										
PCDH8	5100	broad.mit.edu	37	chr13	53418738	53418738	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcttcggggacaggtacctgCcaggaggggactggtagagg	18	8	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:53418738C>A	uc001vhi.2	-	3	3373	c.3170G>T	c.(3169-3171)GGC>GTC	p.G1057V	PCDH8_uc001vhj.2_Missense_Mutation_p.G960V	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	1057	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGGTACCTGCCAGGAGGGGA	0.547													1	0	3.09479e-21	0.006999	3.32818e-21	38	39										A	53418738	C	A	53418738	3	1	19	1	0	0	0	0	1	0	0	0	11517	739	26	4	46	4	PCDH8	13	53418738	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4481696	53418738	61751140	394	5504										
MYCBP2	23077	broad.mit.edu	37	chr13	77743847	77743847	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagcagttctggaatgtcatCagctaaaaaaaggcataaaa	8	7	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:77743847C>T	uc001vkf.2	-	40	5774	c.5683G>A	c.(5683-5685)GAT>AAT	p.D1895N	MYCBP2_uc010aev.2_Missense_Mutation_p.D1299N	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGAATGTCATCAGCTAAAAAA	0.398													0	0	0	0.007413	0	20	34										T	77743847	C	T	77743847	3	4	19	1	0	0	0	0	1	0	0	0	10018	826	29	1	8419	1	MYCBP2	13	77743847	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	24325109	77743847	37426031	395	5505										
RBM26	64062	broad.mit.edu	37	chr13	79943007	79943007	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attactgtaatagtgctgctCaaagtaggtacagggtagtg	12	5	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:79943007C>G	uc001vkz.2	-	6	767	c.753G>C	c.(751-753)TTG>TTC	p.L251F	RBM26_uc001vky.2_Missense_Mutation_p.L251F|RBM26_uc001vla.2_Missense_Mutation_p.L251F|RBM26_uc001vkx.2_5'UTR|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	251					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TAGTGCTGCTCAAAGTAGGTA	0.398													0	0	0	0.009096	0	3	131										G	79943007	C	G	79943007	3	3	19	1	0	0	0	0	1	0	0	0	13126	825	29	1	2253	1	RBM26	13	79943007	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2199160	79943007	35226871	396	5506										
IPO5	3843	broad.mit.edu	37	chr13	98652878	98652880	+	In_Frame_Del	DEL	ATT	ATT	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgccgatgatcaaggaacacAttatgcaaatgcttcaaaat							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:98652878_98652880delATT	uc001vnf.1	+	10	1152_1154	c.1087_1089delATT	c.(1087-1089)ATTdel	p.I363del	IPO5_uc001vne.2_In_Frame_Del_p.I381del|IPO5_uc010tik.1_In_Frame_Del_p.I238del|IPO5_uc010til.1_In_Frame_Del_p.I303del|IPO5_uc001vng.1_5'Flank	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	363	Ran-GTP binding (By similarity).				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						CAAGGAACACATTATGCAAATGC	0.414																		36	97	---	---								-	98652880	ATT	-	98652878	7	5	19	1	0	1	0	1	0	0	0	0	7796	217	8	0	1183	0	IPO5	13	98652878	In_Frame_Del	DEL	ATT	TCGA-BT-A3PJ-01A-21D-A21Z-08	18709871	98652878	16517000	397	5507										
NALCN	259232	broad.mit.edu	37	chr13	102029158	102029158	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agtagaaaaatggaaacactCcatatttgttctcccgatcg	7	9	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:102029158C>T	uc001vox.1	-	6	726	c.537G>A	c.(535-537)TGG>TGA	p.W179*	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Nonsense_Mutation_p.W179*|NALCN_uc001vpa.2_Nonsense_Mutation_p.W179*	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	179	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGGAAACACTCCATATTTGTT	0.308													0	0	0	0.014323	0	19	105										T	102029158	C	T	102029158	4	4	19	1	0	0	0	0	0	1	0	0	10148	856	30	1	4835	1	NALCN	13	102029158	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3376280	102029158	13140720	398	5508										
TPP2	7174	broad.mit.edu	37	chr13	103279421	103279421	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actttccagaagaacctgaaCggaatggggtagctcctggt	12	9	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:103279421C>A	uc001vpi.3	+	7	947	c.844C>A	c.(844-846)CGG>AGG	p.R282R		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	282					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGAACCTGAACGGAATGGGGT	0.463													1	0	5.8336e-16	0.003271	6.21728e-16	31	92										A	103279421	C	A	103279421	2	1	19	1	0	0	0	0	0	0	0	1	16409	527	19	4		4	TPP2	13	103279421	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1250263	103279421	11890457	399	5509										
ATP11A	23250	broad.mit.edu	37	chr13	113532536	113532536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacctcgggactaagactaaGagccagtgcctttctgtcga	11	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:113532536G>C	uc001vsi.3	+	29	3421	c.3333G>C	c.(3331-3333)AAG>AAC	p.K1111N	ATP11A_uc001vsj.3_Intron|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1111	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTAAGACTAAGAGCCAGTGCC	0.527													0	0	0	0.012213	0	30	66										C	113532536	G	C	113532536	3	2	19	1	0	0	0	0	1	0	0	0	1119	933	33	1	3447	1	ATP11A	13	113532536	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	10253115	113532536	1637342	400	5510										
RPGRIP1	57096	broad.mit.edu	37	chr14	21792872	21792872	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggataaagtggatatttctCtgctgcatcagggtgagaat	12	5	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:21792872C>G	uc001wag.2	+	14	1858	c.1858C>G	c.(1858-1860)CTG>GTG	p.L620V	RPGRIP1_uc001wah.2_Missense_Mutation_p.L262V|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_Missense_Mutation_p.L85V|RPGRIP1_uc001wak.2_Missense_Mutation_p.L95V|RPGRIP1_uc010aim.2_Intron|RPGRIP1_uc001wal.2_Silent_p.L28L|RPGRIP1_uc001wam.2_5'UTR	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	620					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GGATATTTCTCTGCTGCATCA	0.493													0	0	0	0.012319	0	17	85										G	21792872	C	G	21792872	3	3	19	1	0	0	0	0	1	0	0	0	13549	912	32	1	1912	1	RPGRIP1	14	21792872	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		21792872	85556668	401	5511										
JUB	84962	broad.mit.edu	37	chr14	23444283	23444283	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatgcatcggaaacagcctgGatgataggacttccccattg	10	10	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:23444283G>T	uc001whz.2	-	5	1646	c.1270C>A	c.(1270-1272)CCA>ACA	p.P424T	JUB_uc001why.2_Missense_Mutation_p.P7T	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	424	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AAACAGCCTGGATGATAGGAC	0.517													1	0	1.06801e-11	0.009535	1.1248e-11	29	103										T	23444283	G	T	23444283	3	4	19	1	0	0	0	0	1	0	0	0	7968	1174	41	3	362	3	JUB	14	23444283	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1651411	23444283	83905257	402	5512										
CEBPE	1053	broad.mit.edu	37	chr14	23588121	23588121	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggcctcaggcgctggcttCacggcaaagagatcggagag	15	11	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:23588121C>T	uc001wiv.1	-	1	354	c.180G>A	c.(178-180)GTG>GTA	p.V60V		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		GCGCTGGCTTCACGGCAAAGA	0.632													0	0	0	0.004289	0	33	62										T	23588121	C	T	23588121	2	4	19	1	0	0	0	0	0	0	0	1	3202	813	29	1		1	CEBPE	14	23588121	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	143838	23588121	83761419	403	5513										
CTSG	1511	broad.mit.edu	37	chr14	25044606	25044606	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggggcctgctctcccggcctCcgatgatctcccctggaagg	13	16	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:25044606C>G	uc001wpq.2	-	2	105	c.68G>C	c.(67-69)GGA>GCA	p.G23A		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	23	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CTCCCGGCCTCCGATGATCTC	0.567													0	0	0	0.01441	0	108	128										G	25044606	C	G	25044606	3	3	19	1	0	0	0	0	1	0	0	0	4035	855	30	1	715	1	CTSG	14	25044606	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1456485	25044606	82304934	404	5514										
AP4S1	11154	broad.mit.edu	37	chr14	31535513	31535513	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggaaacagaagtcataaaGagctgtctctctcgatccaa	8	10	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:31535513G>A	uc001wqy.3	+	2	493	c.111G>A	c.(109-111)AAG>AAA	p.K37K	AP4S1_uc001wqw.3_Silent_p.K37K|AP4S1_uc001wqx.3_Silent_p.K37K|AP4S1_uc010amh.2_Silent_p.K37K|AP4S1_uc001wqz.3_RNA	NM_001128126	NP_001121598	Q9Y587	AP4S1_HUMAN	adaptor-related protein complex 4, sigma 1	37						coated pit|Golgi apparatus	protein transporter activity				0	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.221)	GBM - Glioblastoma multiforme(265;0.00553)		AAGTCATAAAGAGCTGTCTCT	0.393													0	0	0	0.00278	0	20	72										A	31535513	G	A	31535513	2	1	19	1	0	0	0	0	0	0	0	1	754	933	33	1		1	AP4S1	14	31535513	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	6490907	31535513	75814027	405	5515										
PPP2R3C	55012	broad.mit.edu	37	chr14	35557192	35557192	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgaaacaggatcttgtccatGgattttcattagttcctgta	8	7	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:35557192G>A	uc001wss.2	-	12	1492	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	PPP2R3C_uc001wst.2_Missense_Mutation_p.H264Y|PPP2R3C_uc010tpr.1_Missense_Mutation_p.H264Y|PPP2R3C_uc001wsu.2_RNA	NM_017917	NP_060387	Q969Q6	P2R3C_HUMAN	serine/threonine-protein phosphatase 2A	380						centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		TCTTGTCCATGGATTTTCATT	0.308													0	0	0	0.004007	0	13	24										A	35557192	G	A	35557192	3	1	19	1	0	0	0	0	1	0	0	0	12390	1348	47	2	231	2	PPP2R3C	14	35557192	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4021679	35557192	71792348	406	5516										
NIN	51199	broad.mit.edu	37	chr14	51237206	51237208	+	In_Frame_Del	DEL	AGG	AGG	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gctgcttgcctgcctgctgcAggatctgctctctctctttt							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:51237206_51237208delAGG	uc001wym.2	-	12	1523_1525	c.1332_1334delCCT	c.(1330-1335)ATCCTG>ATG	p.444_445IL>M	NIN_uc001wyi.2_In_Frame_Del_p.444_445IL>M|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_In_Frame_Del_p.444_445IL>M|NIN_uc010tqp.1_In_Frame_Del_p.450_451IL>M|NIN_uc001wyo.2_In_Frame_Del_p.444_445IL>M|NIN_uc001wyp.1_In_Frame_Del_p.406_407IL>M	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	444_445	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCCTGCTGCAGGATCTGCTCTC	0.448			T	PDGFRB	MPD													14	55	---	---								-	51237208	AGG	-	51237206	7	5	19	1	0	1	0	1	0	0	0	0	10417	188	7	0	5295	0	NIN	14	51237206	In_Frame_Del	DEL	AGG	TCGA-BT-A3PJ-01A-21D-A21Z-08	15680014	51237206	56112334	407	5517										
GMFB	2764	broad.mit.edu	37	chr14	54948149	54948149	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggttgtcgttcaggtagttCatctttaagttcatctggtg	11	6	5	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:54948149C>T	uc010tqz.1	-	4	277	c.178G>A	c.(178-180)GAA>AAA	p.E60K	GMFB_uc001xaw.1_RNA	NM_004124	NP_004115	P60983	GMFB_HUMAN	glia maturation factor, beta	60	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity				0						TCAGGTAGTTCATCTTTAAGT	0.378													0	0	0	0.004482	0	6	42										T	54948149	C	T	54948149	3	4	19	1	0	0	0	0	1	0	0	0	6489	835	29	1	266	1	GMFB	14	54948149	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3710943	54948149	52401391	408	5518										
KIAA0831	22863	broad.mit.edu	37	chr14	55852662	55852662	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcgaagatttgccagacgctCataatgacttcttaagtcaa	7	9	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:55852662C>A	uc001xbx.1	-	5	598	c.562G>T	c.(562-564)GAG>TAG	p.E188*	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Nonsense_Mutation_p.E75*	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	188					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						GCCAGACGCTCATAATGACTT	0.423													1	0	0.000442599	0.006214	0.000450819	7	39										A	55852662	C	A	55852662	4	1	19	1	0	0	0	0	0	1	0	0	8195	835	29	3	940	3	KIAA0831	14	55852662	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	904513	55852662	51496878	409	5519										
AKAP5	9495	broad.mit.edu	37	chr14	64936344	64936344	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcagttgtcaatagaacagcTggttaatgaaatggcctctg	10	7	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:64936344T>G	uc001xhd.3	+	2	1610	c.1232T>G	c.(1231-1233)CTG>CGG	p.L411R	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	411					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		ATAGAACAGCTGGTTAATGAA	0.348													0	0	0	0.014323	0	19	84										G	64936344	T	G	64936344	3	3	19	1	0	0	0	0	1	0	0	0	454	1580	55	5	1234	5	AKAP5	14	64936344	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	9083682	64936344	42413196	410	5520										
ARG2	384	broad.mit.edu	37	chr14	68086727	68086727	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcagcctctcgcgtctcctCcagacgcgagtgcattccat	10	16	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:68086727C>T	uc001xjs.2	+	1	149	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	11					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	CGCGTCTCCTCCAGACGCGAG	0.617													0	0	0	0.004672	0	3	17										T	68086727	C	T	68086727	2	4	19	1	0	0	0	0	0	0	0	1	858	842	30	1		1	ARG2	14	68086727	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3150383	68086727	39262813	411	5521										
PNMA1	9240	broad.mit.edu	37	chr14	74179620	74179620	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atctgggcatccctagagctCtcaacgctcccaaacacctg	7	16	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:74179620C>T	uc001xor.1	-	1	1509	c.723G>A	c.(721-723)GAG>GAA	p.E241E		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	241					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		ccctagagctctcaacgctcc	0													0	0	0	0.004878	0	33	99										T	74179620	C	T	74179620	2	4	19	1	0	0	0	0	0	0	0	1	12153	912	32	1		1	PNMA1	14	74179620	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	6092893	74179620	33169920	412	5522										
ZC3H14	79882	broad.mit.edu	37	chr14	89044479	89044479	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggagattctgtagaaaaaaAtcaaggtaataacttaaatg	8	3	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:89044479A>T	uc001xww.2	+	9	1499	c.1274A>T	c.(1273-1275)AAT>ATT	p.N425I	ZC3H14_uc010twd.1_Missense_Mutation_p.N425I|ZC3H14_uc010twe.1_Missense_Mutation_p.N425I|ZC3H14_uc001xwx.2_Missense_Mutation_p.N425I|ZC3H14_uc010twf.1_Missense_Mutation_p.N270I|ZC3H14_uc001xwy.2_Missense_Mutation_p.N391I|ZC3H14_uc010twg.1_Missense_Mutation_p.N270I|ZC3H14_uc001xxa.2_5'UTR	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	425						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						GTAGAAAAAAATCAAGGTAAT	0.343													0	0	0	0.010729	0	9	44										T	89044479	A	T	89044479	3	4	19	1	0	0	0	0	1	0	0	0	17563	101	4	5	1308	5	ZC3H14	14	89044479	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	14864859	89044479	18305061	413	5523										
SLC24A4	123041	broad.mit.edu	37	chr14	92922835	92922835	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acattgagaacgggaatgttCctgtggaaaaccccgaagac	11	9	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:92922835C>A	uc001yak.2	+	12	1111	c.1087C>A	c.(1087-1089)CCT>ACT	p.P363T	SLC24A4_uc001yai.2_Missense_Mutation_p.P316T|SLC24A4_uc010twm.1_Missense_Mutation_p.P361T|SLC24A4_uc001yaj.2_Missense_Mutation_p.P344T|SLC24A4_uc010auj.2_Missense_Mutation_p.P252T|SLC24A4_uc010twn.1_Missense_Mutation_p.P136T|SLC24A4_uc001yan.2_Missense_Mutation_p.P74T	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	380	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CGGGAATGTTCCTGTGGAAAA	0.597											OREG0022876	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	6.33695e-27	0.007835	6.86663e-27	38	51										A	92922835	C	A	92922835	3	1	19	1	0	0	0	0	1	0	0	0	14468	855	30	3	1133	3	SLC24A4	14	92922835	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3878356	92922835	14426705	414	5524										
HSP90AA1	3320	broad.mit.edu	37	chr14	102551654	102551654	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caaaaagagtaatgggatatCcaataaactgagaatgtttc	8	5	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:102551654C>G	uc001yku.3	-	4	834	c.644G>C	c.(643-645)GGA>GCA	p.G215A	HSP90AA1_uc001ykv.3_Missense_Mutation_p.G337A|HSP90AA1_uc001ykw.1_Missense_Mutation_p.G36A|HSP90AA1_uc001ykx.1_Missense_Mutation_p.G204A	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	215					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	AATGGGATATCCAATAAACTG	0.378													0	0	0	0.009096	0	4	32										G	102551654	C	G	102551654	3	3	19	1	0	0	0	0	1	0	0	0	7401	855	30	1	1586	1	HSP90AA1	14	102551654	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9628819	102551654	4797886	415	5525										
OCA2	4948	broad.mit.edu	37	chr15	28326981	28326981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caggagctccaccgccggcgCgccggggtaccgcctgccgt	15	18	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:28326981C>T	uc001zbh.3	-	2	150	c.40G>A	c.(40-42)GCG>ACG	p.A14T	OCA2_uc010ayv.2_Missense_Mutation_p.A14T	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	14	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ACCGCCGGCGCGCCGGGGTAC	0.657									Oculocutaneous_Albinism				0	0	0	0.00245	0	12	30										T	28326981	C	T	28326981	3	4	19	1	0	0	0	0	1	0	0	0	10815	768	27	2	2568	2	OCA2	15	28326981	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		28326981	74204411	416	5526										
RYR3	6263	broad.mit.edu	37	chr15	33916209	33916209	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctctttcatcccatgcccCgtagacaccagtcaggtagg	9	15	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:33916209C>T	uc001zhi.2	+	20	2629	c.2559C>T	c.(2557-2559)CCC>CCT	p.P853P	RYR3_uc010bar.2_Silent_p.P853P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	853	4 X approximate repeats.|1.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCCATGCCCCGTAGACACCA	0.438													0	0	0	0.01441	0	76	129										T	33916209	C	T	33916209	2	4	19	1	0	0	0	0	0	0	0	1	13770	639	23	2		2	RYR3	15	33916209	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5589228	33916209	68615183	417	5527										
BUB1B	701	broad.mit.edu	37	chr15	40512774	40512774	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tatatttttaggctaaaagaTggtgaattgtggaataaatt	9	1	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40512774T>C	uc001zkx.3	+	23	3179	c.2967T>C	c.(2965-2967)GAT>GAC	p.D989D	PAK6_uc010bbl.2_Intron|PAK6_uc010bbm.2_Intron	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	989	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GGCTAAAAGATGGTGAATTGT	0.358			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.004007	0	16	58										C	40512774	T	C	40512774	2	2	19	1	0	0	0	0	0	0	0	1	1571	1461	51	5		5	BUB1B	15	40512774	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	6596565	40512774	62018618	418	5528										
PLCB2	5330	broad.mit.edu	37	chr15	40594208	40594208	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcagcttccacccgcttgcGgtcagcaggaaacatctgga	11	13	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40594208G>A	uc001zld.2	-	7	833	c.532C>T	c.(532-534)CGC>TGC	p.R178C	PLCB2_uc010bbo.2_Missense_Mutation_p.R178C|PLCB2_uc010ucm.1_Missense_Mutation_p.R178C|PLCB2_uc001zle.3_Missense_Mutation_p.R178C	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	178					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		ACCCGCTTGCGGTCAGCAGGA	0.582													0	0	0	0.004672	0	3	61										A	40594208	G	A	40594208	3	1	19	1	0	0	0	0	1	0	0	0	12028	1116	39	2	3129	2	PLCB2	15	40594208	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	81434	40594208	61937184	419	5529										
C15orf52	388115	broad.mit.edu	37	chr15	40627522	40627522	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgggctctgggagccctgctCctctctgtggctcagggcaa	14	14	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40627522C>T	uc001zlh.3	-	11	1458	c.1442G>A	c.(1441-1443)GGA>GAA	p.G481E	C15orf52_uc010ucn.1_Missense_Mutation_p.G271E	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	481										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GAGCCCTGCTCCTCTCTGTGG	0.657													0	0	0	0.003954	0	23	108										T	40627522	C	T	40627522	3	4	19	1	0	0	0	0	1	0	0	0	1800	855	30	1	166	1	C15orf52	15	40627522	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	33314	40627522	61903870	420	5530										
EHD4	30844	broad.mit.edu	37	chr15	42202032	42202032	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatacacttggcatctccttCttcaggtagctgatgatgta	8	9	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:42202032C>T	uc001zot.2	-	5	1017	c.954G>A	c.(952-954)AAG>AAA	p.K318K		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	318					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GCATCTCCTTCTTCAGGTAGC	0.438													0	0	0	0.010504	0	17	54										T	42202032	C	T	42202032	2	4	19	1	0	0	0	0	0	0	0	1	4980	912	32	1		1	EHD4	15	42202032	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1574510	42202032	60329360	421	5531										
LRRC57	255252	broad.mit.edu	37	chr15	42840409	42840409	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggacaagtcgatggtcctgaGattgctcgtcagcttctgca	12	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:42840409G>A	uc001zqd.1	-	2	486	c.118C>T	c.(118-120)CTC>TTC	p.L40F	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Missense_Mutation_p.L40F	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	40	LRR 1.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		ATGGTCCTGAGATTGCTCGTC	0.552													0	0	0	0.007835	0	34	137										A	42840409	G	A	42840409	3	1	19	1	0	0	0	0	1	0	0	0	9013	942	33	1	617	1	LRRC57	15	42840409	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	638377	42840409	59690983	422	5532										
MAP1A	4130	broad.mit.edu	37	chr15	43816763	43816763	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcaggaggcagactcctgggGagacactaagcgcacaccag	13	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:43816763G>T	uc001zrt.2	+	4	3559	c.3092G>T	c.(3091-3093)GGA>GTA	p.G1031V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1031						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GACTCCTGGGGAGACACTAAG	0.562													1	0	4.67007e-22	0.00874	5.03745e-22	41	50										T	43816763	G	T	43816763	3	4	19	1	0	0	0	0	1	0	0	0	9227	1174	41	3	3094	3	MAP1A	15	43816763	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	976354	43816763	58714629	423	5533										
COPS2	9318	broad.mit.edu	37	chr15	49431772	49431772	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatagaattaatggatttttCagaataatttcttgtgactg	7	3	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:49431772C>G	uc001zxf.2	-	4	404	c.325G>C	c.(325-327)GAA>CAA	p.E109Q	COPS2_uc001zxh.2_Missense_Mutation_p.E109Q|COPS2_uc010ufa.1_Missense_Mutation_p.E45Q	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	109					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ATGGATTTTTCAGAATAATTT	0.313													0	0	0	0.003271	0	31	34										G	49431772	C	G	49431772	3	3	19	1	0	0	0	0	1	0	0	0	3733	835	29	1	1067	1	COPS2	15	49431772	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5615009	49431772	53099620	424	5534										
DMXL2	23312	broad.mit.edu	37	chr15	51791720	51791720	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagataccaagtctatagatCtaagaagaacccatcttgac	6	9	3	5			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:51791720C>T	uc002abf.2	-	18	3926	c.3701G>A	c.(3700-3702)AGA>AAA	p.R1234K	DMXL2_uc010ufy.1_Missense_Mutation_p.R1234K|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1234						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GTCTATAGATCTAAGAAGAAC	0.428													0	0	0	0.012213	0	30	53										T	51791720	C	T	51791720	3	4	19	1	0	0	0	0	1	0	0	0	4595	913	32	1	5516	1	DMXL2	15	51791720	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2359948	51791720	50739672	425	5535										
WDR72	256764	broad.mit.edu	37	chr15	54003547	54003547	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcccacctgttcagcagctgAtagatgtaactgtgaccatc	9	12	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:54003547A>G	uc002acj.2	-	8	885	c.843T>C	c.(841-843)TAT>TAC	p.Y281Y	WDR72_uc010bfi.1_Silent_p.Y281Y	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	281										lung(1)|skin(1)	2				all cancers(107;0.0511)		TCAGCAGCTGATAGATGTAAC	0.448													0	0	0	0.004289	0	34	58										G	54003547	A	G	54003547	2	3	19	1	0	0	0	0	0	0	0	1	17319	340	12	5		5	WDR72	15	54003547	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2211827	54003547	48527845	426	5536										
PIGB	9488	broad.mit.edu	37	chr15	55611498	55611498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggagccggggggcggagatgCcagcctcactttgcatggtc	17	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:55611498C>T	uc002act.2	+	1	366	c.50C>T	c.(49-51)GCC>GTC	p.A17V	uc002acs.2_5'Flank|PIGB_uc010ugg.1_5'UTR	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	17					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		GGCGGAGATGCCAGCCTCACT	0.592													0	0	0	0.004672	0	3	20										T	55611498	C	T	55611498	3	4	19	1	0	0	0	0	1	0	0	0	11885	739	26	2	52	2	PIGB	15	55611498	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1607951	55611498	46919894	427	5537										
LIPC	3990	broad.mit.edu	37	chr15	58855765	58855765	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcacgctggatgtggatatcGgcgagctgatcatgatcaag	13	8	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:58855765G>C	uc010bga.1	+	10	1839	c.1231G>C	c.(1231-1233)GGC>CGC	p.G411R	LIPC_uc010bfz.1_Missense_Mutation_p.G411R|LIPC_uc002afa.1_Missense_Mutation_p.G411R|LIPC_uc010bgb.1_Missense_Mutation_p.G309R|LIPC_uc010ugy.1_Missense_Mutation_p.G350R	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	411	PLAT.				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TGTGGATATCGGCGAGCTGAT	0.468													0	0	0	0.004289	0	31	139										C	58855765	G	C	58855765	3	2	19	1	0	0	0	0	1	0	0	0	8820	1116	39	4	1261	4	LIPC	15	58855765	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3244267	58855765	43675627	428	5538										
HERC1	8925	broad.mit.edu	37	chr15	63908715	63908715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtagagcagatccacctcctCcaggtcctctagggtgagtg	12	12	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:63908715C>T	uc002amp.2	-	75	14003	c.13855G>A	c.(13855-13857)GAG>AAG	p.E4619K		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4619	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCCACCTCCTCCAGGTCCTCT	0.542													0	0	0	0.00278	0	25	51										T	63908715	C	T	63908715	3	4	19	1	0	0	0	0	1	0	0	0	7057	864	30	1	746	1	HERC1	15	63908715	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5052950	63908715	38622677	429	5539										
HERC1	8925	broad.mit.edu	37	chr15	63948074	63948074	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttctcttcagcaattcctcgGagaaagctgggtagaaactt	9	9	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:63948074G>A	uc002amp.2	-	50	10099	c.9951C>T	c.(9949-9951)CTC>CTT	p.L3317L		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3317					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CAATTCCTCGGAGAAAGCTGG	0.443													0	0	0	0.00245	0	11	8										A	63948074	G	A	63948074	2	1	19	1	0	0	0	0	0	0	0	1	7057	1161	41	1		1	HERC1	15	63948074	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	39359	63948074	38583318	430	5540										
HERC1	8925	broad.mit.edu	37	chr15	64010869	64010869	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tatacacaacggtacacttcTgataagtgtttaccaggttg	8	8	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64010869T>C	uc002amp.2	-	21	4030	c.3882A>G	c.(3880-3882)TCA>TCG	p.S1294S	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1294					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GGTACACTTCTGATAAGTGTT	0.358													0	0	0	0.004672	0	3	8										C	64010869	T	C	64010869	2	2	19	1	0	0	0	0	0	0	0	1	7057	1567	55	5		5	HERC1	15	64010869	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	62795	64010869	38520523	431	5541										
HERC1	8925	broad.mit.edu	37	chr15	64067652	64067652	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctggcaactgtggtcctttGaggcataaaacttgttgggg	13	7	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64067652G>C	uc002amp.2	-	2	319	c.171C>G	c.(169-171)CTC>CTG	p.L57L	HERC1_uc010uil.1_Silent_p.L57L|HERC1_uc010bgt.1_Silent_p.L57L|HERC1_uc002amq.1_Silent_p.L57L	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	57					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GTGGTCCTTTGAGGCATAAAA	0.443													0	0	0	0.012319	0	17	41										C	64067652	G	C	64067652	2	2	19	1	0	0	0	0	0	0	0	1	7057	1277	45	1		1	HERC1	15	64067652	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	56783	64067652	38463740	432	5542										
PPIB	5479	broad.mit.edu	37	chr15	64455081	64455081	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	actttgggccccttcttcttCtcatcggccgcagaaggtcc	9	15	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64455081C>T	uc002and.2	-	1	274	c.105G>A	c.(103-105)GAG>GAA	p.E35E	PPIB_uc010bgx.1_Silent_p.E27E	NM_000942	NP_000933	P23284	PPIB_HUMAN	peptidylprolyl isomerase B precursor	35					protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding				0					L-Proline(DB00172)	CCTTCTTCTTCTCATCGGCCG	0.667													0	0	0	0.006214	0	8	23										T	64455081	C	T	64455081	2	4	19	1	0	0	0	0	0	0	0	1	12319	912	32	1		1	PPIB	15	64455081	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	387429	64455081	38076311	433	5543										
C15orf44	81556	broad.mit.edu	37	chr15	65871971	65871971	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tccaggaaaccaaaggctagAgcggcctttcgcaaacggtt	11	11	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:65871971A>C	uc002apd.2	-	12	1668	c.1332T>G	c.(1330-1332)GCT>GCG	p.A444A	C15orf44_uc010uix.1_Silent_p.A480A|C15orf44_uc010uiz.1_Silent_p.A408A|C15orf44_uc010uja.1_Silent_p.A394A|C15orf44_uc010ujb.1_Silent_p.A365A|C15orf44_uc002ape.3_Silent_p.A444A|C15orf44_uc010uiy.1_Silent_p.A365A	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	444										ovary(1)	1						CAAAGGCTAGAGCGGCCTTTC	0.507													0	0	0	0.00499	0	15	53										C	65871971	A	C	65871971	2	2	19	1	0	0	0	0	0	0	0	1	1798	291	11	5		5	C15orf44	15	65871971	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	1416890	65871971	36659421	434	5544										
GLCE	26035	broad.mit.edu	37	chr15	69561007	69561007	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtggctggccaattatggtGacccgtaagttaggggaagg	17	6	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69561007G>C	uc002ary.1	+	5	1506	c.1278G>C	c.(1276-1278)GTG>GTC	p.V426V		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	426	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						CAATTATGGTGACCCGTAAGT	0.488													0	0	0	0.012213	0	29	48										C	69561007	G	C	69561007	2	2	19	1	0	0	0	0	0	0	0	1	6432	1277	45	1		1	GLCE	15	69561007	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3689036	69561007	32970385	435	5545										
GLCE	26035	broad.mit.edu	37	chr15	69561321	69561321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aactgcaggggaaaaactcgGaaaagaagcaaggtccttgt	12	7	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69561321G>A	uc002ary.1	+	5	1820	c.1592G>A	c.(1591-1593)GGA>GAA	p.G531E		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	531	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						GAAAAACTCGGAAAAGAAGCA	0.428													0	0	0	0.00333	0	19	44										A	69561321	G	A	69561321	3	1	19	1	0	0	0	0	1	0	0	0	6432	1174	41	1	1602	1	GLCE	15	69561321	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	314	69561321	32970071	436	5546										
KIF23	9493	broad.mit.edu	37	chr15	69737226	69737226	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtagatcataagcccgcctCtaacatgcaaactgaaacag	8	11	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69737226C>T	uc002asb.2	+	19	2594	c.2477C>T	c.(2476-2478)TCT>TTT	p.S826F	KIF23_uc002asc.2_Missense_Mutation_p.S722F|KIF23_uc010bii.2_Intron|KIF23_uc010ukc.1_Missense_Mutation_p.S539F	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	826					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						AAGCCCGCCTCTAACATGCAA	0.478													0	0	0	0.01441	0	56	78										T	69737226	C	T	69737226	3	4	19	1	0	0	0	0	1	0	0	0	8291	913	32	1	2551	1	KIF23	15	69737226	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	175905	69737226	32794166	437	5547										
ARID3B	10620	broad.mit.edu	37	chr15	74836792	74836792	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	accttctgtctccacagcagGacagccgaactggaatctgg	10	13	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:74836792G>C	uc002aye.2	+	2	716	c.515G>C	c.(514-516)GGA>GCA	p.G172A	ARID3B_uc002ayc.2_Missense_Mutation_p.G172A|ARID3B_uc002ayd.2_Missense_Mutation_p.G172A	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						TCCACAGCAGGACAGCCGAAC	0.512													0	0	0	0.008361	0	25	37										C	74836792	G	C	74836792	3	2	19	1	0	0	0	0	1	0	0	0	917	1174	41	1	517	1	ARID3B	15	74836792	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5099566	74836792	27694600	438	5548										
CYP1A2	1544	broad.mit.edu	37	chr15	75043585	75043585	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcacagcaagaaggggcctaGagccagcggcaacctcatcc	12	14	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:75043585G>C	uc002ayr.1	+	3	951	c.887G>C	c.(886-888)AGA>ACA	p.R296T		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	296					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	AAGGGGCCTAGAGCCAGCGGC	0.557													0	0	0	0.009718	0	40	61										C	75043585	G	C	75043585	3	2	19	1	0	0	0	0	1	0	0	0	4150	942	33	1	893	1	CYP1A2	15	75043585	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	206793	75043585	27487807	439	5549										
RCN2	5955	broad.mit.edu	37	chr15	77241555	77241555	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgactatttctatcatgatGagctttaatctctgagcctg	7	8	3	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:77241555G>A	uc002bcd.2	+	7	1167	c.946G>A	c.(946-948)GAG>AAG	p.E316K	RCN2_uc002bce.2_Missense_Mutation_p.E388K|RCN2_uc010bks.2_Missense_Mutation_p.E269K	NM_002902	NP_002893	Q14257	RCN2_HUMAN	reticulocalbin 2 precursor	316	Prevents secretion from ER (Potential).					endoplasmic reticulum lumen	calcium ion binding				0						CTATCATGATGAGCTTTAATC	0.388													0	0	0	0.003163	0	13	65										A	77241555	G	A	77241555	3	1	19	1	0	0	0	0	1	0	0	0	13180	1291	45	1	972	1	RCN2	15	77241555	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2197970	77241555	25289837	440	5550										
ARNT2	9915	broad.mit.edu	37	chr15	80767365	80767365	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttataggaactgaagcatctCatccttgaagcagctgatgg	10	8	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:80767365C>G	uc002bfr.2	+	5	589	c.423C>G	c.(421-423)CTC>CTG	p.L141L	ARNT2_uc002bfq.2_Silent_p.L141L|ARNT2_uc010unm.1_Silent_p.L130L|ARNT2_uc002bfs.2_Silent_p.L130L	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	141	PAS 1.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			TGAAGCATCTCATCCTTGAAG	0.453													0	0	0	0.001984	0	6	382										G	80767365	C	G	80767365	2	3	19	1	0	0	0	0	0	0	0	1	966	813	29	1		1	ARNT2	15	80767365	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3525810	80767365	21764027	441	5551										
FAM108C1	58489	broad.mit.edu	37	chr15	80988240	80988240	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttctacattggcctcggctCccgcatcaactgcaacatct	6	16	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:80988240C>T	uc002bfu.2	+	1	589	c.470C>T	c.(469-471)TCC>TTC	p.S157F	FAM108C1_uc002bft.2_Missense_Mutation_p.S150F	NM_021214	NP_067037	Q6PCB6	F108C_HUMAN	hypothetical protein LOC58489	157							hydrolase activity				0						GGCCTCGGCTCCCGCATCAAC	0.637													0	0	0	0.000602	0	4	16										T	80988240	C	T	80988240	3	4	19	1	0	0	0	0	1	0	0	0	5393	855	30	1	472	1	FAM108C1	15	80988240	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	220875	80988240	21543152	442	5552										
STARD5	80765	broad.mit.edu	37	chr15	81605709	81605709	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtaaccgctgaggtcggtaTggaagaatgtgaccaggttg	16	6	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:81605709T>C	uc002bgm.2	-	6	614	c.530A>G	c.(529-531)CAT>CGT	p.H177R	STARD5_uc002bgn.2_Missense_Mutation_p.H70R	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	177	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						GAGGTCGGTATGGAAGAATGT	0.562													0	0	0	0.01441	0	58	86										C	81605709	T	C	81605709	3	2	19	1	0	0	0	0	1	0	0	0	15259	1464	51	5	115	5	STARD5	15	81605709	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	617469	81605709	20925683	443	5553										
ALPK3	57538	broad.mit.edu	37	chr15	85407673	85407673	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagggtgaaactatgtttagGatcatcccactgtatctgat	9	8	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:85407673G>A	uc002ble.2	+	12	5273	c.5106G>A	c.(5104-5106)GAG>GAA	p.E1702E	ALPK3_uc010upc.1_Silent_p.R3R	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1702	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTATGTTTAGGATCATCCCAC	0.517													0	0	0	0.011902	0	41	66										A	85407673	G	A	85407673	2	1	19	1	0	0	0	0	0	0	0	1	546	1188	41	1		1	ALPK3	15	85407673	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3801964	85407673	17123719	444	5554										
AKAP13	11214	broad.mit.edu	37	chr15	86122380	86122380	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtgatttgtcaagcatagttGaggaggagaatacagaccgt	13	5	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:86122380G>A	uc002blv.1	+	7	1251	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	AKAP13_uc002blt.1_Missense_Mutation_p.E361K|AKAP13_uc002blu.1_Missense_Mutation_p.E361K	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	361					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AAGCATAGTTGAGGAGGAGAA	0.493													0	0	0	0.008291	0	11	52										A	86122380	G	A	86122380	3	1	19	1	0	0	0	0	1	0	0	0	449	1291	45	1	1103	1	AKAP13	15	86122380	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	714707	86122380	16409012	445	5555										
MAN2A2	4122	broad.mit.edu	37	chr15	91450061	91450061	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgtgccaacctcaccagcatGctgattcagagagtgcacta	9	13	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:91450061G>A	uc010bnz.2	+	7	1042	c.927G>A	c.(925-927)ATG>ATA	p.M309I	MAN2A2_uc010boa.2_Missense_Mutation_p.M351I|MAN2A2_uc002bqc.2_Missense_Mutation_p.M309I|MAN2A2_uc010uql.1_Missense_Mutation_p.M13I|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	309	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TCACCAGCATGCTGATTCAGA	0.597													0	0	0	0.00333	0	24	69										A	91450061	G	A	91450061	3	1	19	1	0	0	0	0	1	0	0	0	9215	1319	46	2	949	2	MAN2A2	15	91450061	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5327681	91450061	11081331	446	5556										
SV2B	9899	broad.mit.edu	37	chr15	91810843	91810843	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagaatgaatacactgattcTggccgtggtttggtttgcca	11	8	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:91810843T>C	uc002bqv.2	+	7	1569	c.1178T>C	c.(1177-1179)CTG>CCG	p.L393P	SV2B_uc002bqt.2_Missense_Mutation_p.L393P|SV2B_uc010uqv.1_Missense_Mutation_p.L242P|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	393	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			ACACTGATTCTGGCCGTGGTT	0.443													0	0	0	0.001168	0	4	28										C	91810843	T	C	91810843	3	2	19	1	0	0	0	0	1	0	0	0	15415	1580	55	5	1204	5	SV2B	15	91810843	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	360782	91810843	10720549	447	5557										
LINS1	55180	broad.mit.edu	37	chr15	101112154	101112154	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcagcctccagcatgtcatCgtcttgttctatgaaaaccc	8	13	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:101112154C>T	uc002bwe.2	-	7	1630	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	LINS1_uc002bwd.2_Missense_Mutation_p.D34N|LINS1_uc002bwf.2_Missense_Mutation_p.D447N|LINS1_uc002bwg.2_Missense_Mutation_p.D447N|LINS1_uc002bwh.2_Missense_Mutation_p.D447N	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	447											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			AGCATGTCATCGTCTTGTTCT	0.448													0	0	0	0.01441	0	39	48										T	101112154	C	T	101112154	3	4	19	1	0	0	0	0	1	0	0	0	8818	884	31	1	942	1	LINS1	15	101112154	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9301311	101112154	1419238	448	5558										
TELO2	9894	broad.mit.edu	37	chr16	1559872	1559872	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acgaggactgcaggacgctgGcactgagggccctgctgctt	15	12	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:1559872G>T	uc002cly.2	+	21	2740	c.2449G>T	c.(2449-2451)GCA>TCA	p.A817S		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	817						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				CAGGACGCTGGCACTGAGGGC	0.642													1	0	1.08611e-07	0.010729	1.12231e-07	9	28										T	1559872	G	T	1559872	3	4	19	1	0	0	0	0	1	0	0	0	15754	1203	42	4	2527	4	TELO2	16	1559872	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		1559872	88794881	449	5559										
CREBBP	1387	broad.mit.edu	37	chr16	3786760	3786760	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gatcaggtgggtggcaatggAagatgtaatcatctccttca	12	7	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:3786760A>G	uc002cvv.2	-	27	4655	c.4451T>C	c.(4450-4452)TTC>TCC	p.F1484S	CREBBP_uc002cvw.2_Missense_Mutation_p.F1446S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1484	Cys/His-rich.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGGCAATGGAAGATGTAATC	0.507			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.01441	0	58	60										G	3786760	A	G	3786760	3	3	19	1	0	0	0	0	1	0	0	0	3861	246	9	5	2897	5	CREBBP	16	3786760	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2226888	3786760	86567993	450	5560										
TAOK2	9344	broad.mit.edu	37	chr16	29994974	29994988	+	Splice_Site	DEL	ACCGCCTCCCTGGTG	ACCGCCTCCCTGGTG	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	accactttgccaccatccgaAccgcctccctggtgagtgta					rs61737875		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:29994974_29994988delACCGCCTCCCTGGTG	uc002dva.1	+	13	2205	c.1422_splice	c.e13+1	p.L474_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Splice_Site_p.L474_splice|TAOK2_uc002dvc.1_Splice_Site_p.L474_splice|TAOK2_uc010bzm.1_Splice_Site_p.L481_splice|TAOK2_uc002dvd.1_Splice_Site_p.L301_splice	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2						actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CACCATCCGAACCGCCTCCCTGGTGAGTGTAGCCA	0.577																		44	396	---	---								-	29994988	ACCGCCTCCCTGGTG	-	29994974	8	5	19	1	0	1	0	1	0	0	1	0	15545	43	2	0	1457	0	TAOK2	16	29994974	Splice_Site	DEL	ACCGCCTCCCTGGTG	TCGA-BT-A3PJ-01A-21D-A21Z-08	26208214	29994974	60359779	451	5561										
NOD2	64127	broad.mit.edu	37	chr16	50733855	50733855	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caggttgccgatcttcacacCgtcccagagggtgaggcact	12	13	2	2	rs144368009		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:50733855C>T	uc002egm.1	+	2	635	c.530C>T	c.(529-531)CCG>CTG	p.P177L	NOD2_uc010cbj.1_Missense_Mutation_p.P150L|NOD2_uc010cbk.1_Missense_Mutation_p.P150L|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	177	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				ATCTTCACACCGTCCCAGAGG	0.542													0	0	0	0.009096	0	4	71										T	50733855	C	T	50733855	3	4	19	1	0	0	0	0	1	0	0	0	10517	652	23	2	536	2	NOD2	16	50733855	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	20738881	50733855	39620898	452	5562										
KATNB1	10300	broad.mit.edu	37	chr16	57787344	57787344	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcgccgcagccccagcagcGaggatgaccgggacgagcgc	16	15	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:57787344G>A	uc002eml.1	+	12	1464	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	364	Interaction with PAFAH1B1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CCCCAGCAGCGAGGATGACCG	0.662													0	0	0	0.013537	0	10	77										A	57787344	G	A	57787344	3	1	19	1	0	0	0	0	1	0	0	0	7987	1059	37	1	1132	1	KATNB1	16	57787344	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7053489	57787344	32567409	453	5563										
PLEKHG4	25894	broad.mit.edu	37	chr16	67314065	67314065	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aagaggaggaacctgcttccCagatgcacgttaaggaccca	11	11	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:67314065C>T	uc002eso.3	+	1	2653	c.118C>T	c.(118-120)CAG>TAG	p.Q40*	PLEKHG4_uc002esp.3_5'UTR|PLEKHG4_uc002esq.3_Nonsense_Mutation_p.Q40*|PLEKHG4_uc002esr.1_Nonsense_Mutation_p.Q40*|PLEKHG4_uc010cef.2_Nonsense_Mutation_p.Q40*|PLEKHG4_uc002ess.3_Nonsense_Mutation_p.Q40*|PLEKHG4_uc010ceg.2_Nonsense_Mutation_p.Q40*	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	40					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		ACCTGCTTCCCAGATGCACGT	0.592													0	0	0	0.01441	0	55	50										T	67314065	C	T	67314065	4	4	19	1	0	0	0	0	0	1	0	0	12071	595	21	2	120	2	PLEKHG4	16	67314065	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	9526721	67314065	23040688	454	5564										
THAP11	57215	broad.mit.edu	37	chr16	67877394	67877394	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgtcatccgcaagaagcacGgaatgtgaactggtgccccg	12	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:67877394G>T	uc002euo.2	+	1	1182	c.937G>T	c.(937-939)GGA>TGA	p.G313*	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		CAAGAAGCACGGAATGTGAAC	0.612													1	0	6.53348e-20	0.003755	7.01562e-20	31	39										T	67877394	G	T	67877394	4	4	19	1	0	0	0	0	0	1	0	0	15840	1117	39	4	939	4	THAP11	16	67877394	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	563329	67877394	22477359	455	5565										
CIRH1A	84916	broad.mit.edu	37	chr16	69202805	69202805	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgacatcattgctcagctcCcaccacccattaaaaagaag	5	13	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:69202805C>T	uc002ews.3	+	17	2122	c.2026C>T	c.(2026-2028)CCA>TCA	p.P676S	CIRH1A_uc002ewt.3_Missense_Mutation_p.P593S|CIRH1A_uc010cfi.2_Missense_Mutation_p.P478S	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	676						nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		TGCTCAGCTCCCACCACCCAT	0.443													0	0	0	0.000602	0	4	141										T	69202805	C	T	69202805	3	4	19	1	0	0	0	0	1	0	0	0	3434	623	22	2	2088	2	CIRH1A	16	69202805	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1325411	69202805	21151948	456	5566										
SNTB2	6645	broad.mit.edu	37	chr16	69279609	69279609	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caccaagctttagtggcagtGaggactctggttcgccaaaa	11	10	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:69279609G>A	uc002ewu.2	+	2	705	c.685G>A	c.(685-687)GAG>AAG	p.E229K		NM_006750	NP_006741	Q13425	SNTB2_HUMAN	basic beta 2 syntrophin	229	PH 1.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		TAGTGGCAGTGAGGACTCTGG	0.493													0	0	0	0.01441	0	189	214										A	69279609	G	A	69279609	3	1	19	1	0	0	0	0	1	0	0	0	14873	1291	45	1	691	1	SNTB2	16	69279609	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	76804	69279609	21075144	457	5567										
COG4	25839	broad.mit.edu	37	chr16	70531255	70531255	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcatccaccatgctggatgtCagctggcccttctcataggt	9	13	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:70531255C>T	uc002ezc.2	-	11	1361	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	COG4_uc002ezb.2_5'UTR|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Silent_p.L450L|COG4_uc002eze.2_Silent_p.L144L	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	446					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TGCTGGATGTCAGCTGGCCCT	0.512													0	0	0	0.01441	0	91	114										T	70531255	C	T	70531255	2	4	19	1	0	0	0	0	0	0	0	1	3660	813	29	1		1	COG4	16	70531255	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1251646	70531255	19823498	458	5568										
SF3B3	23450	broad.mit.edu	37	chr16	70602260	70602260	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctgatgtccaagaaagtttCatctgggttcgctacaagcg	10	9	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:70602260C>A	uc002ezf.2	+	22	3238	c.3027C>A	c.(3025-3027)TTC>TTA	p.F1009L		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1009					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				AAGAAAGTTTCATCTGGGTTC	0.433													1	0	1.96642e-18	0.006999	2.10519e-18	40	51										A	70602260	C	A	70602260	3	1	19	1	0	0	0	0	1	0	0	0	14152	825	29	3	3109	3	SF3B3	16	70602260	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	71005	70602260	19752493	459	5569										
RFWD3	55159	broad.mit.edu	37	chr16	74678291	74678291	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcctgttcactagtgtccaAagctctcagggttcgggcat	10	12	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:74678291A>C	uc002fda.2	-	6	1146	c.1048T>G	c.(1048-1050)TTG>GTG	p.L350V	RFWD3_uc010cgq.2_Missense_Mutation_p.L350V	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	350					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTAGTGTCCAAAGCTCTCAGG	0.453													0	0	0	0.01441	0	36	227										C	74678291	A	C	74678291	3	2	19	1	0	0	0	0	1	0	0	0	13261	11	1	5	1308	5	RFWD3	16	74678291	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	4076031	74678291	15676462	460	5570										
CNTNAP4	85445	broad.mit.edu	37	chr16	76592577	76592577	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatcagaaagagtacttcttCtgattggcagctatgattta	8	6	3	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:76592577C>T	uc002feu.1	+	26	4309	c.3924C>T	c.(3922-3924)TTC>TTT	p.F1308F	CNTNAP4_uc002fev.1_Silent_p.F1172F|CNTNAP4_uc010chb.1_Silent_p.F1235F|CNTNAP4_uc002fex.1_Silent_p.F1311F	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1308	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						AGTACTTCTTCTGATTGGCAG	0.363													0	0	0	0.004482	0	9	13										T	76592577	C	T	76592577	2	4	19	1	0	0	0	0	0	0	0	1	3649	912	32	1		1	CNTNAP4	16	76592577	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1914286	76592577	13762176	461	5571										
SLC38A8	146167	broad.mit.edu	37	chr16	84075602	84075602	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccaggaaggcagggaccactCcgcccgctttggagaaggcc	14	14	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:84075602C>T	uc002fhg.1	-	1	161	c.161G>A	c.(160-162)GGA>GAA	p.G54E		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	54					amino acid transport|sodium ion transport	integral to membrane					0						AGGGACCACTCCGCCCGCTTT	0.637													0	0	0	0.00333	0	18	174										T	84075602	C	T	84075602	3	4	19	1	0	0	0	0	1	0	0	0	14610	855	30	1	1186	1	SLC38A8	16	84075602	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	7483025	84075602	6279151	462	5572										
LRRC50	123872	broad.mit.edu	37	chr16	84211366	84211366	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcgccgccacacccccagaGacgtgtgtcggagttgccca	12	16	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:84211366G>C	uc002fhl.3	+	12	2278	c.2097G>C	c.(2095-2097)GAG>GAC	p.E699D	LRRC50_uc010vnw.1_Missense_Mutation_p.E463D	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	699					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CACCCCCAGAGACGTGTGTCG	0.592									Kartagener_syndrome				0	0	0	0.01441	0	57	257										C	84211366	G	C	84211366	3	2	19	1	0	0	0	0	1	0	0	0	9009	933	33	1	2143	1	LRRC50	16	84211366	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	135764	84211366	6143387	463	5573										
FOXC2	2303	broad.mit.edu	37	chr16	86601790	86601790	+	Frame_Shift_Del	DEL	G	G	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	accctgcgaacgtcgccgccGggcggagagctgagcccggg							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:86601790delG	uc002fjq.2	+	1	934	c.849delG	c.(847-849)CCGfs	p.P283fs		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	283					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						CGTCGCCGCCGGGCGGAGAGC	0.677									Late-onset_Hereditary_Lymphedema									2	4	---	---								-	86601790	G	-	86601790	7	5	19	1	0	1	0	1	0	0	0	0	5995	1103	39	0	851	0	FOXC2	16	86601790	Frame_Shift_Del	DEL	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2390424	86601790	3752963	464	5574										
RNMTL1	55178	broad.mit.edu	37	chr17	691281	691281	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cattcactgcctttattattGatttgtgacaatctccgtga	6	9	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:691281G>C	uc002frw.2	+	3	742	c.636G>C	c.(634-636)TTG>TTC	p.L212F		NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	212					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CTTTATTATTGATTTGTGACA	0.463													0	0	0	0.01441	0	62	140										C	691281	G	C	691281	3	2	19	1	0	0	0	0	1	0	0	0	13507	1281	45	1	646	1	RNMTL1	17	691281	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		691281	80503929	465	5575										
SLC25A11	8402	broad.mit.edu	37	chr17	4841188	4841188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcggacaactttgaacagcaCgtcctagacacagacaggca	10	12	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:4841188C>T	uc002fzo.1	-	8	906	c.793G>A	c.(793-795)GTG>ATG	p.V265M	SLC25A11_uc002fzp.1_Missense_Mutation_p.V261M|RNF167_uc002fzq.2_5'Flank|RNF167_uc002fzr.2_5'Flank|RNF167_uc002fzs.2_5'Flank|RNF167_uc002fzt.2_5'Flank|RNF167_uc002fzu.2_5'Flank|RNF167_uc002fzv.2_5'Flank	NM_003562	NP_003553	Q02978	M2OM_HUMAN	solute carrier family 25 member 11 isoform 1	265	Solcar 3.				gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity				0						TTGAACAGCACGTCCTAGACA	0.627													0	0	0	0.010818	0	28	69										T	4841188	C	T	4841188	3	4	19	1	0	0	0	0	1	0	0	0	14473	536	19	2	155	2	SLC25A11	17	4841188	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4149907	4841188	76354022	466	5576										
DHX33	56919	broad.mit.edu	37	chr17	5352201	5352201	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcttgctgttgacaaaattCtctttgcaccaatcctgaat	5	10	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:5352201C>A	uc002gca.2	-	11	1745	c.1743G>T	c.(1741-1743)GAG>GAT	p.E581D	DHX33_uc002gbz.2_Missense_Mutation_p.E352D|DHX33_uc002gcb.2_Missense_Mutation_p.E408D|DHX33_uc010clf.2_Missense_Mutation_p.E357D	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	581						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						TGACAAAATTCTCTTTGCACC	0.368													1	0	8.28177e-16	0.007413	8.81329e-16	15	28										A	5352201	C	A	5352201	3	1	19	1	0	0	0	0	1	0	0	0	4506	912	32	3	388	3	DHX33	17	5352201	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	511013	5352201	75843009	467	5577										
XAF1	54739	broad.mit.edu	37	chr17	6659401	6659401	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctgcagagagcagaacatgGaaggagacttctcggtgtgc	14	9	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:6659401G>A	uc002gdn.2	+	1	246	c.4G>A	c.(4-6)GAA>AAA	p.E2K	XAF1_uc010clr.1_Missense_Mutation_p.E2K|XAF1_uc002gdm.1_5'UTR|XAF1_uc002gdo.2_Missense_Mutation_p.E2K|XAF1_uc002gdp.2_5'UTR|XAF1_uc002gdq.2_5'UTR|XAF1_uc002gdr.2_5'UTR	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	2					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						GCAGAACATGGAAGGAGACTT	0.537													0	0	0	0.01441	0	86	43										A	6659401	G	A	6659401	3	1	19	1	0	0	0	0	1	0	0	0	17416	1175	41	1	6	1	XAF1	17	6659401	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1307200	6659401	74535809	468	5578										
TP53	7157	broad.mit.edu	37	chr17	7577108	7577108	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcgccggtctctcccaggaCaggcacaaacacgcacctca	9	17	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:7577108C>A	uc002gim.2	-	8	1024	c.830G>T	c.(829-831)TGT>TTT	p.C277F	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C277F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C145F|TP53_uc010cng.1_Missense_Mutation_p.C145F|TP53_uc002gii.1_Missense_Mutation_p.C145F|TP53_uc010cnh.1_Missense_Mutation_p.C277F|TP53_uc010cni.1_Missense_Mutation_p.C277F|TP53_uc002gij.2_Missense_Mutation_p.C277F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	277	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> W (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> Y (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C277F(20)|p.C277Y(15)|p.0?(7)|p.C277*(6)|p.C277G(4)|p.C277C(4)|p.?(2)|p.C277W(2)|p.C277fs*29(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.C277_P278insXXXXXXX(1)|p.L265_K305del41(1)|p.C275_R283delCACPGRDRR(1)|p.S269fs*21(1)|p.A276_C277delAC(1)|p.F270_D281del12(1)|p.C275fs*67(1)|p.C277R(1)|p.C277S(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCCCAGGACAGGCACAAAC	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	4.96729e-08	0.008871	5.14779e-08	21	23										A	7577108	C	A	7577108	3	1	19	1	0	0	0	0	1	0	0	0	16378	478	17	4	456	4	TP53	17	7577108	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	917707	7577108	73618102	469	5579										
ALOXE3	59344	broad.mit.edu	37	chr17	8018935	8018935	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccaccctcaccggtagcattCttgtcgggcccggagctccc	10	18	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:8018935C>G	uc010cnr.2	-	4	794	c.424G>C	c.(424-426)GAA>CAA	p.E142Q	ALOXE3_uc002gka.2_Missense_Mutation_p.E298Q|ALOXE3_uc010vuo.1_Missense_Mutation_p.E274Q|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	142	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CGGTAGCATTCTTGTCGGGCC	0.478													0	0	0	0.004878	0	31	58										G	8018935	C	G	8018935	3	3	19	1	0	0	0	0	1	0	0	0	542	922	32	1	1763	1	ALOXE3	17	8018935	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	441827	8018935	73176275	470	5580										
STX8	9482	broad.mit.edu	37	chr17	9153949	9153949	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gccacaagcagcagtaaaatCaccatgatcatccctggaaa	7	12	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:9153949C>T	uc002glx.2	-	8	807	c.657G>A	c.(655-657)GTG>GTA	p.V219V		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8	219	Helical; Anchor for type IV membrane protein; (Potential).				transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						GCAGTAAAATCACCATGATCA	0.463													0	0	0	0.006214	0	7	14										T	9153949	C	T	9153949	2	4	19	1	0	0	0	0	0	0	0	1	15350	813	29	1		1	STX8	17	9153949	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1135014	9153949	72041261	471	5581										
ELAC2	60528	broad.mit.edu	37	chr17	12897026	12897026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcatgtggtcaaaggcaactCccactttctcgctgaagttg	9	11	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:12897026C>T	uc002gnz.3	-	23	2326	c.2231G>A	c.(2230-2232)GGA>GAA	p.G744E	ELAC2_uc002gnu.3_Missense_Mutation_p.G141E|ELAC2_uc002gnv.3_Missense_Mutation_p.G372E|ELAC2_uc002gnw.3_Missense_Mutation_p.G400E|ELAC2_uc002gnx.3_Missense_Mutation_p.G504E|ELAC2_uc010vvo.1_Missense_Mutation_p.G542E|ELAC2_uc010vvp.1_Missense_Mutation_p.G725E|ELAC2_uc010vvq.1_Missense_Mutation_p.G743E|ELAC2_uc010vvr.1_Missense_Mutation_p.G704E	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	744					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						AAAGGCAACTCCCACTTTCTC	0.577									Hereditary_Prostate_Cancer				0	0	0	0.00499	0	15	113										T	12897026	C	T	12897026	3	4	19	1	0	0	0	0	1	0	0	0	5047	855	30	1	257	1	ELAC2	17	12897026	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3743077	12897026	68298184	472	5582										
TRIM16	10626	broad.mit.edu	37	chr17	15532492	15532492	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttgtgtgctgtgtccgggtCaaacgtgatgtcatacgcat	12	9	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15532492C>T	uc002gox.2	-	9	1689	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	TRIM16_uc002gor.1_Missense_Mutation_p.D378N|TRIM16_uc002gow.2_Missense_Mutation_p.D162N|TRIM16_uc002goy.2_Missense_Mutation_p.D248N	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	378	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		GTGTCCGGGTCAAACGTGATG	0.567													0	0	0	0.01441	0	43	75										T	15532492	C	T	15532492	3	4	19	1	0	0	0	0	1	0	0	0	16488	826	29	1	566	1	TRIM16	17	15532492	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2635466	15532492	65662718	473	5583										
NCOR1	9611	broad.mit.edu	37	chr17	15942889	15942889	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttgtcatcaaagcttcccatGagagccttcctgataatgtc	7	11	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15942889G>A	uc002gpo.2	-	44	7053	c.6813C>T	c.(6811-6813)CTC>CTT	p.L2271L	NCOR1_uc002gpn.2_Silent_p.L2168L|NCOR1_uc002gpl.2_Silent_p.L286L|NCOR1_uc002gpm.2_Silent_p.L791L|NCOR1_uc010vwb.1_Silent_p.L855L|NCOR1_uc010coy.2_Silent_p.L1179L	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2271	Interaction with C1D (By similarity).|ID2 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGCTTCCCATGAGAGCCTTCC	0.473													0	0	0	0.013537	0	11	31										A	15942889	G	A	15942889	2	1	19	1	0	0	0	0	0	0	0	1	10235	1277	45	1		1	NCOR1	17	15942889	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	410397	15942889	65252321	474	5584										
RAI1	10743	broad.mit.edu	37	chr17	17696270	17696270	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	accagcccgagtcatgcagtCttttcgagaaaggtgtggtt	12	9	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:17696270C>G	uc002grm.2	+	3	477	c.8C>G	c.(7-9)TCT>TGT	p.S3C	RAI1_uc002grn.1_Missense_Mutation_p.S3C	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	3						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GTCATGCAGTCTTTTCGAGAA	0.378													0	0	0	0.012319	0	21	33										G	17696270	C	G	17696270	3	3	19	1	0	0	0	0	1	0	0	0	13007	913	32	1	10	1	RAI1	17	17696270	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1753381	17696270	63498940	475	5585										
SMCR7	125170	broad.mit.edu	37	chr17	18167285	18167285	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cgggctgcaggcgggggctgCggaccatgtgcgtctcctgg	19	12	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:18167285C>T	uc002gst.2	+	4	783	c.572C>T	c.(571-573)GCG>GTG	p.A191V	SMCR7_uc002gsu.2_Silent_p.C166C|SMCR7_uc010vxq.1_Missense_Mutation_p.A202V	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	191						integral to membrane	protein binding				0	all_neural(463;0.228)					GCGGGGGCTGCGGACCATGTG	0.701													0	0	0	0.006214	0	8	17										T	18167285	C	T	18167285	3	4	19	1	0	0	0	0	1	0	0	0	14790	777	27	2	619	2	SMCR7	17	18167285	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	471015	18167285	63027925	476	5586										
ZNF286B	729288	broad.mit.edu	37	chr17	18565289	18565289	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgaactctttgatgtctgatGagagatgaactgcacttaaa	9	6	2	6			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:18565289G>A	uc010vyd.1	-	5	1781	c.1530C>T	c.(1528-1530)CTC>CTT	p.L510L		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	510	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GATGTCTGATGAGAGATGAAC	0.358													0	0	0	0.00333	0	16	46										A	18565289	G	A	18565289	2	1	19	1	0	0	0	0	0	0	0	1	17821	1277	45	1		1	ZNF286B	17	18565289	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	398004	18565289	62629921	477	5587										
ALDH3A1	218	broad.mit.edu	37	chr17	19648427	19648427	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcgggcgcgcttcacggcctCgctgatcttgctcatggcgc	14	15	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19648427C>T	uc010cqu.2	-	1	346	c.16G>A	c.(16-18)GAG>AAG	p.E6K	ALDH3A1_uc010vzd.1_Missense_Mutation_p.E6K|ALDH3A1_uc002gwj.2_Missense_Mutation_p.E6K|ALDH3A1_uc010cqv.2_Missense_Mutation_p.E6K|ALDH3A1_uc002gwk.2_Intron|ALDH3A1_uc002gwl.1_5'Flank	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	6					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TTCACGGCCTCGCTGATCTTG	0.682													0	0	0	0.00278	0	18	38										T	19648427	C	T	19648427	3	4	19	1	0	0	0	0	1	0	0	0	497	893	31	1	1385	1	ALDH3A1	17	19648427	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1083138	19648427	61546783	478	5588										
AKAP10	11216	broad.mit.edu	37	chr17	19861683	19861683	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agctctgcttcactgtgtttAgactgtgtgctcttattcgc	9	10	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19861683A>T	uc002gwo.2	-	4	658	c.521T>A	c.(520-522)CTA>CAA	p.L174Q	AKAP10_uc002gwp.1_Missense_Mutation_p.L174Q|AKAP10_uc010cqw.1_Missense_Mutation_p.L174Q|AKAP10_uc010vze.1_Missense_Mutation_p.L95Q	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	174	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CACTGTGTTTAGACTGTGTGC	0.413													0	0	0	0.003954	0	26	57										T	19861683	A	T	19861683	3	4	19	1	0	0	0	0	1	0	0	0	446	420	15	5	1515	5	AKAP10	17	19861683	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	213256	19861683	61333527	479	5589										
MAP2K3	5606	broad.mit.edu	37	chr17	21205466	21205466	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cacccacagggagacgtgtgGatctgcatggagctcatgga	14	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:21205466G>T	uc002gys.2	+	6	676	c.411G>T	c.(409-411)TGG>TGT	p.W137C	MAP2K3_uc002gyt.2_Missense_Mutation_p.W108C|MAP2K3_uc002gyu.2_Missense_Mutation_p.W108C	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	137	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GAGACGTGTGGATCTGCATGG	0.507													1	0	1.96292e-10	0.010504	2.05215e-10	15	77										T	21205466	G	T	21205466	3	4	19	1	0	0	0	0	1	0	0	0	9238	1183	41	3	433	3	MAP2K3	17	21205466	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1343783	21205466	59989744	480	5590										
FOXN1	8456	broad.mit.edu	37	chr17	26862193	26862193	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctggatgccatcaatccctCactcactgacttcgacttcc	5	17	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:26862193C>T	uc010crm.2	+	8	1802	c.1604C>T	c.(1603-1605)TCA>TTA	p.S535L	FOXN1_uc002hbj.2_Missense_Mutation_p.S535L	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	535					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					ATCAATCCCTCACTCACTGAC	0.597													0	0	0	0.008871	0	16	37										T	26862193	C	T	26862193	3	4	19	1	0	0	0	0	1	0	0	0	6019	838	29	1	1630	1	FOXN1	17	26862193	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5656727	26862193	54333017	481	5591										
SUPT6H	6830	broad.mit.edu	37	chr17	27010765	27010765	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaacgggctttacagcagttCctctatgtgcagatggccaa	11	10	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27010765C>T	uc002hby.2	+	17	2250	c.2160C>T	c.(2158-2160)TTC>TTT	p.F720F	SUPT6H_uc010crt.2_Silent_p.F720F	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	720					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TACAGCAGTTCCTCTATGTGC	0.473													0	0	0	0.007413	0	19	38										T	27010765	C	T	27010765	2	4	19	1	0	0	0	0	0	0	0	1	15397	854	30	1		1	SUPT6H	17	27010765	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	148572	27010765	54184445	482	5592										
TLCD1	116238	broad.mit.edu	37	chr17	27051729	27051729	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcctgaggggccaggcggaaGagaaagtacatgaccaggtt	16	8	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27051729G>C	uc002hco.2	-	4	658	c.543C>G	c.(541-543)CTC>CTG	p.L181L	TLCD1_uc010waw.1_Silent_p.L134L	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	181	TLC.|Helical; (Potential).					integral to membrane					0	Lung NSC(42;0.00431)					CCAGGCGGAAGAGAAAGTACA	0.512													0	0	0	0.003954	0	23	94										C	27051729	G	C	27051729	2	2	19	1	0	0	0	0	0	0	0	1	15934	929	33	1		1	TLCD1	17	27051729	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	40964	27051729	54143481	483	5593										
TAOK1	57551	broad.mit.edu	37	chr17	27809286	27809286	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agtagatgtgtggtctcttgGaataacatgtattgaactag	11	4	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27809286G>A	uc002hdz.1	+	8	829	c.635G>A	c.(634-636)GGA>GAA	p.G212E	TAOK1_uc010wbe.1_Missense_Mutation_p.G212E|TAOK1_uc010wbf.1_Missense_Mutation_p.G212E|TAOK1_uc002heb.1_Missense_Mutation_p.G38E	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	212	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			TGGTCTCTTGGAATAACATGT	0.313													0	0	0	0.00874	0	36	70										A	27809286	G	A	27809286	3	1	19	1	0	0	0	0	1	0	0	0	15544	1174	41	1	661	1	TAOK1	17	27809286	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	757557	27809286	53385924	484	5594										
CPD	1362	broad.mit.edu	37	chr17	28750013	28750013	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaactttatgtgatggagatAtctgataatccgggtgtcca	11	6	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:28750013A>G	uc002hfb.1	+	5	1644	c.1629A>G	c.(1627-1629)ATA>ATG	p.I543M	CPD_uc010wbo.1_Missense_Mutation_p.I296M|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	543	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						TGATGGAGATATCTGATAATC	0.383													0	0	0	0.003163	0	15	42										G	28750013	A	G	28750013	3	3	19	1	0	0	0	0	1	0	0	0	3798	439	16	5	1647	5	CPD	17	28750013	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	940727	28750013	52445197	485	5595										
CCT6B	10693	broad.mit.edu	37	chr17	33259398	33259398	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agttgtaccttgggaataatGagtaaggcatcagcaaaagc	11	6	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:33259398G>C	uc002hig.2	-	11	1429	c.1335C>G	c.(1333-1335)CTC>CTG	p.L445L	CCT6B_uc010ctg.2_Silent_p.L408L|CCT6B_uc010wcc.1_Silent_p.L400L	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	445					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				TGGGAATAATGAGTAAGGCAT	0.383													0	0	0	0.014323	0	20	82										C	33259398	G	C	33259398	2	2	19	1	0	0	0	0	0	0	0	1	2958	1277	45	1		1	CCT6B	17	33259398	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4509385	33259398	47935812	486	5596										
UNC45B	146862	broad.mit.edu	37	chr17	33482390	33482390	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggagaatgaggagatgtctCtggctgtctgcaacctgctc	13	9	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:33482390C>T	uc002hja.2	+	7	812	c.715C>T	c.(715-717)CTG>TTG	p.L239L	UNC45B_uc002hjb.2_Silent_p.L239L|UNC45B_uc002hjc.2_Silent_p.L239L|UNC45B_uc010cto.2_Silent_p.L239L	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	239	ARM 2.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GGAGATGTCTCTGGCTGTCTG	0.557													0	0	0	0.00623	0	40	72										T	33482390	C	T	33482390	2	4	19	1	0	0	0	0	0	0	0	1	16986	912	32	1		1	UNC45B	17	33482390	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	222992	33482390	47712820	487	5597										
CDC6	990	broad.mit.edu	37	chr17	38445697	38445697	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcaaacccgatcccaggcaCaggctacaatcagttttcca	6	15	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:38445697C>T	uc002huj.1	+	2	235	c.25C>T	c.(25-27)CAG>TAG	p.Q9*		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	9					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						ATCCCAGGCACAGGCTACAAT	0.408													0	0	0	0.003271	0	29	46										T	38445697	C	T	38445697	4	4	19	1	0	0	0	0	0	1	0	0	3083	479	17	2	27	2	CDC6	17	38445697	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4963307	38445697	42749513	488	5598										
KRT25	147183	broad.mit.edu	37	chr17	38910244	38910244	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acatcagcctctacactctgGtgaagagccagctcattttc	7	13	4	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:38910244G>A	uc002hve.2	-	3	598	c.537C>T	c.(535-537)CAC>CAT	p.H179H		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	179	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				CTACACTCTGGTGAAGAGCCA	0.408													0	0	0	0.004007	0	13	71										A	38910244	G	A	38910244	2	1	19	1	0	0	0	0	0	0	0	1	8462	1252	44	2		2	KRT25	17	38910244	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	464547	38910244	42284966	489	5599										
PTRF	284119	broad.mit.edu	37	chr17	40575088	40575088	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtacccgggaagcggccgctCgacaatatagagcgtggggt	16	10	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:40575088C>G	uc002hzo.2	-	1	187	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	PTRF_uc010wgi.1_Missense_Mutation_p.E10Q	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	10					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		AGCGGCCGCTCGACAATATAG	0.726													0	0	0	0.004672	0	3	8										G	40575088	C	G	40575088	3	3	19	1	0	0	0	0	1	0	0	0	12815	893	31	1	1152	1	PTRF	17	40575088	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1664844	40575088	40620122	490	5600										
COASY	80347	broad.mit.edu	37	chr17	40716813	40716813	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agctcaatagctcagcgactGaagggcctgggggcgtttgt	15	9	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:40716813G>A	uc002hzz.2	+	5	1291	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	COASY_uc010cyj.2_Silent_p.L407L|COASY_uc002iab.2_Silent_p.L83L|COASY_uc002iad.2_Silent_p.L378L|COASY_uc002iac.2_Silent_p.L378L|COASY_uc002iae.2_Silent_p.L173L|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	378	DPCK.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CTCAGCGACTGAAGGGCCTGG	0.587													0	0	0	0.006999	0	39	73										A	40716813	G	A	40716813	2	1	19	1	0	0	0	0	0	0	0	1	3652	1277	45	1		1	COASY	17	40716813	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	141725	40716813	40478397	491	5601										
PLCD3	113026	broad.mit.edu	37	chr17	43195690	43195690	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcggtgctgctgggccccccGatctgggagtcagtcagata	14	12	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:43195690G>A	uc002iib.2	-	6	1197	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	361	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	TGGGCCCCCCGATCTGGGAGT	0.592													0	0	0	0.013726	0	28	85										A	43195690	G	A	43195690	2	1	19	1	0	0	0	0	0	0	0	1	12032	1048	37	1		1	PLCD3	17	43195690	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2478877	43195690	37999520	492	5602										
HOXB1	3211	broad.mit.edu	37	chr17	46607930	46607930	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgggccccgtagctcgaggGatgaaaatagcctccgtctc	12	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46607930G>C	uc002ink.1	-	1	343	c.337C>G	c.(337-339)CCC>GCC	p.P113A		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	113						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TAGCTCGAGGGATGAAAATAG	0.642													0	0	0	0.00632	0	25	146										C	46607930	G	C	46607930	3	2	19	1	0	0	0	0	1	0	0	0	7299	1174	41	1	576	1	HOXB1	17	46607930	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3412240	46607930	34587280	493	5603										
HOXB3	3213	broad.mit.edu	37	chr17	46628332	46628332	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggttcagcaggttggccatCtctacacggcgaggccggca	14	12	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46628332C>T	uc002inn.2	-	2	1060	c.660G>A	c.(658-660)GAG>GAA	p.E220E	HOXB3_uc010wlm.1_Silent_p.E147E|HOXB3_uc010dbf.2_Silent_p.E220E|HOXB3_uc010dbg.2_Silent_p.E220E|HOXB3_uc002ino.2_Silent_p.E220E|HOXB3_uc010wlk.1_Silent_p.E88E|HOXB3_uc010wll.1_Silent_p.E147E	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	220	Homeobox.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGTTGGCCATCTCTACACGGC	0.607													0	0	0	0.01441	0	53	229										T	46628332	C	T	46628332	2	4	19	1	0	0	0	0	0	0	0	1	7302	912	32	1		1	HOXB3	17	46628332	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	20402	46628332	34566878	494	5604										
HOXB9	3219	broad.mit.edu	37	chr17	46703546	46703547	+	Missense_Mutation	DNP	GG	GG	AA													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agctcgcgtactggccagaaGgaaacttggctggaggcgcg							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46703546_46703547GG>AA	uc002inx.2	-	1	289_290	c.85_86CC>TT	c.(85-87)CCT>TTT	p.P29F		NM_024017	NP_076922	P17482	HXB9_HUMAN	homeobox B9	29					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGGCCAGAAGGAAACTTGGCT	0.604													0	0	0	0.004672	0	6	24										AA	46703547	GG	AA	46703546	3	1	19	1	0	0	0	0	1	0	0	0	7308	1000	35	2	674	2	HOXB9	17	46703546	Missense_Mutation	DNP	GG	TCGA-BT-A3PJ-01A-21D-A21Z-08	75214	46703546	34491664	495	5605										
EPN3	55040	broad.mit.edu	37	chr17	48614133	48614133	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacagcggcaagaactggcgGcacgtgtacaaggctctaac	13	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:48614133G>A	uc002ira.3	+	2	651	c.216G>A	c.(214-216)CGG>CGA	p.R72R	EPN3_uc010wms.1_Silent_p.R127R|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.R72R	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	72	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGAACTGGCGGCACGTGTACA	0.597													0	0	0	0.009535	0	31	131										A	48614133	G	A	48614133	2	1	19	1	0	0	0	0	0	0	0	1	5187	1190	42	2		2	EPN3	17	48614133	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1910587	48614133	32581077	496	5606										
SPAG9	9043	broad.mit.edu	37	chr17	49198014	49198014	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caccacaccgtcctccagctCcatggtggcaagcggacggg	12	16	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:49198014C>G	uc002itc.2	-	1	213	c.4G>C	c.(4-6)GAG>CAG	p.E2Q	SPAG9_uc002itb.2_Missense_Mutation_p.E2Q|SPAG9_uc002itd.2_Missense_Mutation_p.E2Q	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	2					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TCCTCCAGCTCCATGGTGGCA	0.552													0	0	0	0.001168	0	5	8										G	49198014	C	G	49198014	3	3	19	1	0	0	0	0	1	0	0	0	14985	864	30	1	4081	1	SPAG9	17	49198014	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	583881	49198014	31997196	497	5607										
CA10	56934	broad.mit.edu	37	chr17	49825019	49825019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agagaaggcctgtccattgaGgaggtgctccgacccttggc	14	11	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:49825019G>A	uc002itw.3	-	4	1425	c.439C>T	c.(439-441)CTC>TTC	p.L147F	CA10_uc002itu.3_Missense_Mutation_p.L76F|CA10_uc002itv.3_Missense_Mutation_p.L153F|CA10_uc002itx.3_Missense_Mutation_p.L147F|CA10_uc002ity.3_Missense_Mutation_p.L147F|CA10_uc002itz.2_Missense_Mutation_p.L147F	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	147					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTCCATTGAGGAGGTGCTCC	0.507													0	0	0	0.01441	0	38	183										A	49825019	G	A	49825019	3	1	19	1	0	0	0	0	1	0	0	0	2511	1000	35	2	571	2	CA10	17	49825019	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	627005	49825019	31370191	498	5608										
PCTP	58488	broad.mit.edu	37	chr17	53844767	53844767	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccaactctactggcagacatCtatatggactcagattacag	7	11	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:53844767C>T	uc002iul.3	+	2	322	c.213C>T	c.(211-213)ATC>ATT	p.I71I	PCTP_uc002ium.3_5'UTR|PCTP_uc010dcg.2_Silent_p.I71I|PCTP_uc010dch.2_RNA	NM_021213	NP_067036	Q9UKL6	PPCT_HUMAN	phosphatidylcholine transfer protein isoform 1	71	START.					cytosol	phosphatidylcholine binding|phosphatidylcholine transmembrane transporter activity			lung(1)	1			BRCA - Breast invasive adenocarcinoma(1;0.00207)			TGGCAGACATCTATATGGACT	0.323													0	0	0	0.00632	0	21	36										T	53844767	C	T	53844767	2	4	19	1	0	0	0	0	0	0	0	1	11607	903	32	1		1	PCTP	17	53844767	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4019748	53844767	27350443	499	5609										
PTRH2	51651	broad.mit.edu	37	chr17	57775139	57775139	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcatttcgaaccacaagaatCatcttgtactccccgctgtc	5	14	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:57775139C>T	uc002ixt.2	-	2	326	c.201G>A	c.(199-201)ATG>ATA	p.M67I	PTRH2_uc002ixs.2_RNA	NM_016077	NP_057161	Q9Y3E5	PTH2_HUMAN	Bcl-2 inhibitor of transcription precursor	67					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CCACAAGAATCATCTTGTACT	0.468													0	0	0	0.003755	0	36	93										T	57775139	C	T	57775139	3	4	19	1	0	0	0	0	1	0	0	0	12817	826	29	1	342	1	PTRH2	17	57775139	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3930372	57775139	23420071	500	5610										
KCNH6	81033	broad.mit.edu	37	chr17	61623247	61623247	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcagatcctggatttgcagGgagttggggccactgaactc	13	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:61623247G>A	uc002jay.2	+	14	3049	c.2969G>A	c.(2968-2970)GGG>GAG	p.G990E	KCNH6_uc010wpl.1_Missense_Mutation_p.G831E|KCNH6_uc010wpm.1_Missense_Mutation_p.G954E|KCNH6_uc002jaz.1_Missense_Mutation_p.G901E	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	990	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GGATTTGCAGGGAGTTGGGGC	0.507													0	0	0	0.007413	0	17	52										A	61623247	G	A	61623247	3	1	19	1	0	0	0	0	1	0	0	0	8036	1232	43	2	3023	2	KCNH6	17	61623247	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	3848108	61623247	19571963	501	5611										
DDX5	1655	broad.mit.edu	37	chr17	62499341	62499341	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aatcttccttatttggggttCaaagcccatatcaagcattc	6	10	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62499341C>T	uc002jek.2	-	7	1022	c.775G>A	c.(775-777)GAA>AAA	p.E259K	DDX5_uc010deh.2_Missense_Mutation_p.E259K|DDX5_uc002jej.2_Missense_Mutation_p.E154K|DDX5_uc010wqa.1_Missense_Mutation_p.E180K|DDX5_uc002jel.1_Missense_Mutation_p.E7K	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	259	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			ATTTGGGGTTCAAAGCCCATA	0.363			T	ETV4	prostate								0	0	0	0.004656	0	20	92										T	62499341	C	T	62499341	3	4	19	1	0	0	0	0	1	0	0	0	4367	835	29	1	1097	1	DDX5	17	62499341	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	876094	62499341	18695869	502	5612										
CCDC45	90799	broad.mit.edu	37	chr17	62523291	62523291	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaccataaagaagaaaatacTggaaatgaggaggtagagga	13	3	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62523291T>C	uc002jem.2	+	11	1273	c.1215T>C	c.(1213-1215)ACT>ACC	p.T405T	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Silent_p.T241T	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	405						centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AAGAAAATACTGGAAATGAGG	0.413													0	0	0	0.001984	0	6	30										C	62523291	T	C	62523291	2	2	19	1	0	0	0	0	0	0	0	1	2816	1567	55	5		5	CCDC45	17	62523291	Silent	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	23950	62523291	18671919	503	5613										
BPTF	2186	broad.mit.edu	37	chr17	65890162	65890162	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaatacagggcaaattggatCaaggcagttcagatgtgtag	12	5	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:65890162C>G	uc002jgf.2	+	7	2485	c.2424C>G	c.(2422-2424)ATC>ATG	p.I808M	BPTF_uc002jge.2_Missense_Mutation_p.I934M|BPTF_uc010wqm.1_Missense_Mutation_p.I871M	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	934					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAAATTGGATCAAGGCAGTTC	0.393													0	0	0	0.01441	0	48	69										G	65890162	C	G	65890162	3	3	19	1	0	0	0	0	1	0	0	0	1495	816	29	1	2836	1	BPTF	17	65890162	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3366871	65890162	15305048	504	5614										
COG1	9382	broad.mit.edu	37	chr17	71192710	71192710	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gatcaagctactcttagaaaTtccggagaagatctggagct	10	8	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:71192710T>A	uc002jjg.2	+	2	416	c.380T>A	c.(379-381)ATT>AAT	p.I127N	COG1_uc002jjh.2_Missense_Mutation_p.I127N|COG1_uc002jjf.1_Missense_Mutation_p.I127N	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	127					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			CTCTTAGAAATTCCGGAGAAG	0.557													0	0	0	0.01441	0	65	118										A	71192710	T	A	71192710	3	1	19	1	0	0	0	0	1	0	0	0	3657	1493	52	5	386	5	COG1	17	71192710	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	5302548	71192710	10002500	505	5615										
BTBD17	388419	broad.mit.edu	37	chr17	72353375	72353375	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggaactggtaggcctgcagCaggaggtcggccaccgcggg	18	11	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:72353375C>T	uc002jkn.2	-	3	858	c.858G>A	c.(856-858)CTG>CTA	p.L286L		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	286						extracellular region					0						AGGCCTGCAGCAGGAGGTCGG	0.711													0	0	0	0.001168	0	4	6										T	72353375	C	T	72353375	2	4	19	1	0	0	0	0	0	0	0	1	1542	697	25	2		2	BTBD17	17	72353375	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1160665	72353375	8841835	506	5616										
GRB2	2885	broad.mit.edu	37	chr17	73316530	73316530	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caagctcctttccaccagttGgggtctgagttatccatgac	9	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:73316530G>C	uc002jnx.3	-	6	930	c.573C>G	c.(571-573)CCC>CCG	p.P191P	GRB2_uc002jny.3_Silent_p.P150P	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	191	SH3 2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TCCACCAGTTGGGGTCTGAGT	0.537													0	0	0	0.01441	0	56	196										C	73316530	G	C	73316530	2	2	19	1	0	0	0	0	0	0	0	1	6758	1335	47	4		4	GRB2	17	73316530	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	963155	73316530	7878680	507	5617										
ITGB4	3691	broad.mit.edu	37	chr17	73727372	73727372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggccctagacagcccccgaGgccttcggacagaggtcacc	13	16	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:73727372G>A	uc002jpg.2	+	10	1325	c.1138G>A	c.(1138-1140)GGC>AGC	p.G380S	ITGB4_uc002jph.2_Missense_Mutation_p.G380S|ITGB4_uc010dgo.2_Missense_Mutation_p.G380S|ITGB4_uc002jpi.3_Missense_Mutation_p.G380S|ITGB4_uc010dgp.1_Missense_Mutation_p.G380S|ITGB4_uc002jpj.2_Missense_Mutation_p.G380S|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	380	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCCCCCGAGGCCTTCGGAC	0.637													0	0	0	0.003163	0	15	97										A	73727372	G	A	73727372	3	1	19	1	0	0	0	0	1	0	0	0	7897	1000	35	2	1172	2	ITGB4	17	73727372	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	410842	73727372	7467838	508	5618										
SFRS2	6427	broad.mit.edu	37	chr17	74732409	74732409	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggacttggacttggaccttCgtgcggatctggacttggag	15	8	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:74732409C>T	uc002jsv.2	-	2	670	c.500G>A	c.(499-501)CGA>CAA	p.R167Q	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R167Q|SFRS2_uc010wtg.1_Missense_Mutation_p.R155Q|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	167	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						CTTGGACCTTCGTGCGGATCT	0.622													0	0	0	0.00333	0	20	92										T	74732409	C	T	74732409	3	4	19	1	0	0	0	0	1	0	0	0	14175	884	31	1	169	1	SFRS2	17	74732409	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1005037	74732409	6462801	509	5619										
DNAH17	8632	broad.mit.edu	37	chr17	76503684	76503684	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gagatgacggagtccgccgtGgacagcttctgctgccagct	14	12	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:76503684G>A	uc010wtu.1	-	2	492	c.315C>T	c.(313-315)TCC>TCT	p.S105S						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTCCGCCGTGGACAGCTTCT	0.592													0	0	0	0.013537	0	10	55										A	76503684	G	A	76503684	2	1	19	1	0	0	0	0	0	0	0	1	4601	1335	47	2		2	DNAH17	17	76503684	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1771275	76503684	4691526	510	5620										
ENGASE	64772	broad.mit.edu	37	chr17	77082023	77082040	+	In_Frame_Del	DEL	CGCTGCCAGCCTGCTGGC	CGCTGCCAGCCTGCTGGC	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctctcctgccaggtggtggaCgctgccagcctgctggcccc							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:77082023_77082040delCGCTGCCAGCCTGCTGGC	uc002jwv.2	+	14	1832_1849	c.1824_1841delCGCTGCCAGCCTGCTGGC	c.(1822-1842)GACGCTGCCAGCCTGCTGGCC>GAC	p.AASLLA609del	ENGASE_uc002jww.2_In_Frame_Del_p.AASLLA314del	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	609_614						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						AGGTGGTGGACGCTGCCAGCCTGCTGGCCCCTCTGCCC	0.706																		42	73	---	---								-	77082040	CGCTGCCAGCCTGCTGGC	-	77082023	7	5	19	1	0	1	0	1	0	0	0	0	5118	535	19	0	1878	0	ENGASE	17	77082023	In_Frame_Del	DEL	CGCTGCCAGCCTGCTGGC	TCGA-BT-A3PJ-01A-21D-A21Z-08	578339	77082023	4113187	511	5621										
CCDC40	55036	broad.mit.edu	37	chr17	78073333	78073333	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttttcctacccagaacctttCagagatcgtggccctgcaga	8	13	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:78073333C>G	uc010dht.2	+	20	3215	c.3188C>G	c.(3187-3189)TCA>TGA	p.S1063*	CCDC40_uc002jxm.3_Nonsense_Mutation_p.S846*|CCDC40_uc002jxn.3_Nonsense_Mutation_p.S459*|GAA_uc002jxo.2_5'Flank|GAA_uc002jxp.2_5'Flank|GAA_uc002jxq.2_5'Flank	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1063					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CAGAACCTTTCAGAGATCGTG	0.552													0	0	0	0.006999	0	34	35										G	78073333	C	G	78073333	4	3	19	1	0	0	0	0	0	1	0	0	2812	838	29	1	3266	1	CCDC40	17	78073333	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	991310	78073333	3121877	512	5622										
P4HB	5034	broad.mit.edu	37	chr17	79813139	79813139	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cctgcaaaaactgcttggcaGagtccgactccacgtcctga	9	14	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:79813139G>A	uc002kbn.1	-	4	700	c.503C>T	c.(502-504)TCT>TTT	p.S168F	P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	168					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CTGCTTGGCAGAGTCCGACTC	0.552													0	0	0	0.004289	0	35	117										A	79813139	G	A	79813139	3	1	19	1	0	0	0	0	1	0	0	0	11359	942	33	1	1055	1	P4HB	17	79813139	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1739806	79813139	1382071	513	5623										
DLGAP1	9229	broad.mit.edu	37	chr18	3499318	3499318	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tcctggcgctgcgagctctcCagcgagcgctcccggatcag	13	16	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:3499318C>T	uc002kmf.2	-	10	2866	c.2799G>A	c.(2797-2799)CTG>CTA	p.L933L	DLGAP1_uc002kme.1_Silent_p.L631L|DLGAP1_uc010dkn.2_Silent_p.L641L|DLGAP1_uc010wyw.1_Silent_p.L639L|DLGAP1_uc010wyx.1_Silent_p.L655L|DLGAP1_uc010wyy.1_Silent_p.L617L	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	933					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GCGAGCTCTCCAGCGAGCGCT	0.697													0	0	0	0.004672	0	3	9										T	3499318	C	T	3499318	2	4	19	1	0	0	0	0	0	0	0	1	4559	581	21	2		2	DLGAP1	18	3499318	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		3499318	74577930	514	5624										
EPB41L3	23136	broad.mit.edu	37	chr18	5438071	5438071	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tagttgggcagggtctggtgGataaaatttcacattaaatg	12	4	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:5438071G>C	uc002kmt.1	-	6	654	c.568C>G	c.(568-570)CCA>GCA	p.P190A	EPB41L3_uc010wzh.1_Missense_Mutation_p.P190A|EPB41L3_uc002kmu.1_Missense_Mutation_p.P190A|EPB41L3_uc010dkq.1_Missense_Mutation_p.P81A|EPB41L3_uc010dks.1_Missense_Mutation_p.P212A|EPB41L3_uc002kmv.1_Missense_Mutation_p.P81A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	190	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGGTCTGGTGGATAAAATTTC	0.383													0	0	0	0.014323	0	15	49										C	5438071	G	C	5438071	3	2	19	1	0	0	0	0	1	0	0	0	5154	1174	41	1	2763	1	EPB41L3	18	5438071	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1938753	5438071	72639177	515	5625										
MIB1	57534	broad.mit.edu	37	chr18	19321641	19321641	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gggggaagcaggacggcggcGagggccatgtgggcaccgtc	21	10	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:19321641G>A	uc002ktq.2	+	1	97	c.97G>A	c.(97-99)GAG>AAG	p.E33K	MIB1_uc002ktp.2_Intron	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	33	MIB/HERC2 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			GGACGGCGGCGAGGGCCATGT	0.667													0	0	0	0.003163	0	14	22										A	19321641	G	A	19321641	3	1	19	1	0	0	0	0	1	0	0	0	9566	1059	37	1	99	1	MIB1	18	19321641	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	13883570	19321641	58755607	516	5626										
NPC1	4864	broad.mit.edu	37	chr18	21136222	21136222	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gttacctggtgcagtatctgTatgtcaagcggaggtccaaa	12	8	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21136222T>C	uc002kum.3	-	8	1585	c.1311A>G	c.(1309-1311)ATA>ATG	p.I437M	NPC1_uc010xaz.1_Missense_Mutation_p.I238M|NPC1_uc010xba.1_Missense_Mutation_p.I282M	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	437					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GCAGTATCTGTATGTCAAGCG	0.498													0	0	0	0.013114	0	35	71										C	21136222	T	C	21136222	3	2	19	1	0	0	0	0	1	0	0	0	10570	1628	57	5	2597	5	NPC1	18	21136222	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1814581	21136222	56941026	517	5627										
LAMA3	3909	broad.mit.edu	37	chr18	21422437	21422437	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atttttaccaagcagcgcacCcgacgtttcccgcgcaggtg	10	14	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21422437C>A	uc002kuq.2	+	28	3501	c.3415C>A	c.(3415-3417)CCG>ACG	p.P1139T	LAMA3_uc002kur.2_Missense_Mutation_p.P1139T	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1139	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCAGCGCACCCGACGTTTCC	0.582													1	0	6.07242e-22	0.01441	6.54024e-22	56	85										A	21422437	C	A	21422437	3	1	19	1	0	0	0	0	1	0	0	0	8607	623	22	4	3525	4	LAMA3	18	21422437	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	286215	21422437	56654811	518	5628										
LAMA3	3909	broad.mit.edu	37	chr18	21479343	21479343	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgggctgaagcccagcgcatGatgagggaactgcggaacag	16	9	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21479343G>A	uc002kuq.2	+	47	6014	c.5928G>A	c.(5926-5928)ATG>ATA	p.M1976I	LAMA3_uc002kur.2_Intron|LAMA3_uc002kus.3_Missense_Mutation_p.M367I|LAMA3_uc002kut.3_Intron	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1976	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCAGCGCATGATGAGGGAAC	0.493													0	0	0	0.008871	0	16	59										A	21479343	G	A	21479343	3	1	19	1	0	0	0	0	1	0	0	0	8607	1290	45	1	6289	1	LAMA3	18	21479343	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	56906	21479343	56597905	519	5629										
DSG1	1828	broad.mit.edu	37	chr18	28916515	28916515	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggtaatatgggatcaaatGataaagtgggagactttgta	12	3	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:28916515G>A	uc002kwp.2	+	9	1416	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	402	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GGGATCAAATGATAAAGTGGG	0.383													0	0	0	0.001855	0	12	43										A	28916515	G	A	28916515	3	1	19	1	0	0	0	0	1	0	0	0	4776	1290	45	1	1238	1	DSG1	18	28916515	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	7437172	28916515	49160733	520	5630										
KIAA1632	57724	broad.mit.edu	37	chr18	43450624	43450624	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaaagcgtacagaatgaactCtggcattttgggtgctgtac	12	7	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:43450624C>T	uc002lbm.2	-	36	6233	c.6133G>A	c.(6133-6135)GAG>AAG	p.E2045K	KIAA1632_uc010xcq.1_Missense_Mutation_p.E599K|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_Intron|KIAA1632_uc002lbn.2_Missense_Mutation_p.E920K	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2045					autophagy						0						AGAATGAACTCTGGCATTTTG	0.488													0	0	0	0.006122	0	16	39										T	43450624	C	T	43450624	3	4	19	1	0	0	0	0	1	0	0	0	8249	922	32	1	1642	1	KIAA1632	18	43450624	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	14534109	43450624	34626624	521	5631										
MBD1	4152	broad.mit.edu	37	chr18	47800628	47800639	+	In_Frame_Del	DEL	GTCGCAGCAGAA	GTCGCAGCAGAA	-													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgcccccgaatttgggcttGtcgcagcagaagtcgcagcg					rs115570375	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:47800628_47800639delGTCGCAGCAGAA	uc010dow.1	-	11	1500_1511	c.1063_1074delTTCTGCTGCGAC	c.(1063-1074)TTCTGCTGCGACdel	p.FCCD355del	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_In_Frame_Del_p.FCCD305del|MBD1_uc010xdi.1_In_Frame_Del_p.FCCD406del|MBD1_uc002leh.3_Intron|MBD1_uc002len.2_In_Frame_Del_p.FCCD355del|MBD1_uc002lei.3_In_Frame_Del_p.FCCD355del|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_In_Frame_Del_p.FCCD306del|MBD1_uc002lel.3_In_Frame_Del_p.FCCD332del|MBD1_uc002lem.3_In_Frame_Del_p.FCCD355del|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_In_Frame_Del_p.FCCD380del|MBD1_uc010dox.1_In_Frame_Del_p.FCCD332del|MBD1_uc002leo.2_In_Frame_Del_p.FCCD355del	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	355_358	CXXC-type 3.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ATTTGGGCTTGTCGCAGCAGAAGTCGCAGCGG	0.651																		10	124	---	---								-	47800639	GTCGCAGCAGAA	-	47800628	7	5	19	1	0	1	0	1	0	0	0	0	9342	1368	48	0	961	0	MBD1	18	47800628	In_Frame_Del	DEL	GTCGCAGCAGAA	TCGA-BT-A3PJ-01A-21D-A21Z-08	4350004	47800628	30276620	522	5632										
ZNF407	55628	broad.mit.edu	37	chr18	72775115	72775115	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtctcccttaggcattgtttCcaagtcgtacgagtgccgtc	10	12	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:72775115C>T	uc002llw.2	+	8	5495	c.5438C>T	c.(5437-5439)TCC>TTC	p.S1813F		NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1813					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGCATTGTTTCCAAGTCGTAC	0.557													0	0	0	0.01441	0	53	88										T	72775115	C	T	72775115	3	4	19	1	0	0	0	0	1	0	0	0	17884	855	30	1	5598	1	ZNF407	18	72775115	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	24974487	72775115	5302133	523	5633										
ZNF516	9658	broad.mit.edu	37	chr18	74091492	74091492	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	attcttaggcatgctagcggCttttgtgaccactcccaggg	11	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:74091492C>G	uc010dqx.1	-	3	2813	c.2578G>C	c.(2578-2580)GCC>CCC	p.A860P	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	860					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ATGCTAGCGGCTTTTGTGACC	0.617													0	0	0	0.00333	0	22	140										G	74091492	C	G	74091492	3	3	19	1	0	0	0	0	1	0	0	0	17957	797	28	4	930	4	ZNF516	18	74091492	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1316377	74091492	3985756	524	5634										
ATP8B3	148229	broad.mit.edu	37	chr19	1784889	1784889	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agggaaggtgtttatggacaCactcagcaggaccaccagca	12	10	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:1784889C>T	uc002ltw.2	-	28	3823	c.3589G>A	c.(3589-3591)GTG>ATG	p.V1197M	ATP8B3_uc002ltv.2_Missense_Mutation_p.V1160M|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1197	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTATGGACACACTCAGCAGG	0.637													0	0	0	0.006214	0	6	33										T	1784889	C	T	1784889	3	4	19	1	0	0	0	0	1	0	0	0	1196	478	17	2	321	2	ATP8B3	19	1784889	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		1784889	57344094	525	5635										
THOP1	7064	broad.mit.edu	37	chr19	2808407	2808407	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggtggagacctacttccatGagtttggccacgtgatgcac	12	10	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:2808407G>C	uc002lwj.2	+	9	1575	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	THOP1_uc010xgz.1_Missense_Mutation_p.E353Q|THOP1_uc002lwk.2_5'Flank	NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	474		By similarity.			proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTACTTCCATGAGTTTGGCCA	0.512													0	0	0	0.004482	0	7	39										C	2808407	G	C	2808407	3	2	19	1	0	0	0	0	1	0	0	0	15868	1291	45	1	1454	1	THOP1	19	2808407	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1023518	2808407	56320576	526	5636										
CELF5	60680	broad.mit.edu	37	chr19	3290311	3290311	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acgcagatgttcctacccttCggcaatatcatttcctccaa	5	14	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:3290311C>T	uc002lxm.2	+	11	1306	c.1269C>T	c.(1267-1269)TTC>TTT	p.F423F	CELF5_uc002lxl.1_Missense_Mutation_p.R410W|CELF5_uc010dtj.1_Missense_Mutation_p.R385W|CELF5_uc010xhg.1_Missense_Mutation_p.R296W|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	423	RRM 3.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						TCCTACCCTTCGGCAATATCA	0.577													0	0	0	0.010818	0	25	93										T	3290311	C	T	3290311	2	4	19	1	0	0	0	0	0	0	0	1	3219	884	31	1		1	CELF5	19	3290311	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	481904	3290311	55838672	527	5637										
LONP1	9361	broad.mit.edu	37	chr19	5719793	5719793	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggtgcggaaacacatcgggGatcgtcatgggcgtgagcgc	17	9	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:5719793G>A	uc002mcx.2	-	1	384	c.351C>T	c.(349-351)ATC>ATT	p.I117I	TMEM146_uc010duj.1_5'Flank|TMEM146_uc002mda.2_5'Flank|LONP1_uc002mcy.2_Silent_p.I53I|LONP1_uc010duh.2_5'UTR|LONP1_uc010dui.2_Silent_p.I117I|LONP1_uc002mcz.2_Intron	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	117					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						ACACATCGGGGATCGTCATGG	0.532													0	0	0	0.009718	0	42	77										A	5719793	G	A	5719793	2	1	19	1	0	0	0	0	0	0	0	1	8892	1164	41	1		1	LONP1	19	5719793	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2429482	5719793	53409190	528	5638										
RETN	56729	broad.mit.edu	37	chr19	7734744	7734744	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcattggcctggagtgccaGagcgtcacctccagggggga	16	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:7734744G>A	uc002mhf.1	+	3	202	c.156G>A	c.(154-156)CAG>CAA	p.Q52Q	RETN_uc002mhg.1_Silent_p.Q52Q|RETN_uc010dvm.1_Intron	NM_020415	NP_065148	Q9HD89	RETN_HUMAN	resistin	52							hormone activity			ovary(1)	1						TGGAGTGCCAGAGCGTCACCT	0.612													0	0	0	0.004289	0	28	41										A	7734744	G	A	7734744	2	1	19	1	0	0	0	0	0	0	0	1	13236	933	33	1		1	RETN	19	7734744	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2014951	7734744	51394239	529	5639										
MAP2K7	5609	broad.mit.edu	37	chr19	7974989	7974989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gcaggagatcatgaagcagaCgggctacctgaccatcgggg	15	10	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:7974989C>T	uc002mit.2	+	3	373	c.308C>T	c.(307-309)ACG>ATG	p.T103M	MAP2K7_uc002miv.2_Missense_Mutation_p.T103M|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.T103M|MAP2K7_uc010dvv.2_Translation_Start_Site	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	103					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	ATGAAGCAGACGGGCTACCTG	0.647													0	0	0	0.006214	0	7	18										T	7974989	C	T	7974989	3	4	19	1	0	0	0	0	1	0	0	0	9242	536	19	2	318	2	MAP2K7	19	7974989	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	240245	7974989	51153994	530	5640										
QTRT1	81890	broad.mit.edu	37	chr19	10818004	10818004	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acatcatcatgcagctggacGacgtggttagcagtactgtg	12	9	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:10818004G>A	uc002mpr.2	+	4	503	c.478G>A	c.(478-480)GAC>AAC	p.D160N		NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	160					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GCAGCTGGACGACGTGGTTAG	0.572													0	0	0	0.01441	0	39	215										A	10818004	G	A	10818004	3	1	19	1	0	0	0	0	1	0	0	0	12885	1058	37	1	492	1	QTRT1	19	10818004	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2843015	10818004	48310979	531	5641										
DNM2	1785	broad.mit.edu	37	chr19	10897350	10897350	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tacaagaactttcggcccgaCgaccccacccgcaaaaccaa	6	17	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:10897350C>T	uc002mps.1	+	7	1124	c.960C>T	c.(958-960)GAC>GAT	p.D320D	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.D320D|DNM2_uc002mpv.1_Silent_p.D320D|DNM2_uc002mpu.1_Silent_p.D320D|DNM2_uc010dxl.1_Silent_p.D320D|DNM2_uc002mpw.2_Silent_p.D53D	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	320					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TTCGGCCCGACGACCCCACCC	0.637													0	0	0	0.012319	0	21	27										T	10897350	C	T	10897350	2	4	19	1	0	0	0	0	0	0	0	1	4672	535	19	2		2	DNM2	19	10897350	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	79346	10897350	48231633	532	5642										
KANK2	25959	broad.mit.edu	37	chr19	11287304	11287304	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gccccctcagcagtgggtatGtgctgagattctcgagacag	13	11	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11287304G>A	uc010dxv.2	-	9	2268	c.1710C>T	c.(1708-1710)CAC>CAT	p.H570H	KANK2_uc002mqm.2_Silent_p.H578H|KANK2_uc002mqo.3_Silent_p.H570H|KANK2_uc002mqp.1_Silent_p.H379H	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	570											0						CAGTGGGTATGTGCTGAGATT	0.632													0	0	0	0.01441	0	70	244										A	11287304	G	A	11287304	2	1	19	1	0	0	0	0	0	0	0	1	7977	1368	48	2		2	KANK2	19	11287304	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	389954	11287304	47841679	533	5643										
DOCK6	57572	broad.mit.edu	37	chr19	11332547	11332548	+	Missense_Mutation	DNP	GG	GG	AT													0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cagcaaagtcatgcagccgtGgcaaggtatcccgtgcaatc							TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11332547_11332548GG>AT	uc002mqs.3	-	28	3570_3571	c.3529_3530CC>AT	c.(3529-3531)CCA>ATA	p.P1177I	DOCK6_uc010xlq.1_Missense_Mutation_p.P516I	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1177					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						ATGCAGCCGTGGCAAGGTATCC	0.584													0	0	0	0.004672	0	92	204										AT	11332548	GG	AT	11332547	3	1	19	1	0	0	0	0	1	0	0	0	4691	1348	47	2	2697	2	DOCK6	19	11332547	Missense_Mutation	DNP	GG	TCGA-BT-A3PJ-01A-21D-A21Z-08	45243	11332547	47796436	534	5644										
ZNF823	55552	broad.mit.edu	37	chr19	11832850	11832850	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttttctacatgttttacacTcataaggtttttctactgtg	5	8	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11832850T>G	uc002msm.2	-	4	1625	c.1499A>C	c.(1498-1500)GAG>GCG	p.E500A	ZNF823_uc010xmd.1_Missense_Mutation_p.E318A|ZNF823_uc010dyi.1_Missense_Mutation_p.E456A	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	500	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGTTTTACACTCATAAGGTTT	0.378										HNSCC(68;0.2)			0	0	0	0.014323	0	22	28										G	11832850	T	G	11832850	3	3	19	1	0	0	0	0	1	0	0	0	18176	1551	54	5	337	5	ZNF823	19	11832850	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	500303	11832850	47296133	535	5645										
BRD4	23476	broad.mit.edu	37	chr19	15355563	15355563	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgccccttcttttttgacttCggagccatctctgcagagga	9	12	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:15355563C>T	uc002nar.2	-	12	2391	c.2169G>A	c.(2167-2169)CCG>CCA	p.P723P		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	723					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TTTTTGACTTCGGAGCCATCT	0.567			T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.00623	0	34	172										T	15355563	C	T	15355563	2	4	19	1	0	0	0	0	0	0	0	1	1504	871	31	1		1	BRD4	19	15355563	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3522713	15355563	43773420	536	5646										
ANO8	57719	broad.mit.edu	37	chr19	17440802	17440802	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgatgaggtgcttctcatagGcgctctccagccggtaattt	11	10	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:17440802G>C	uc002ngf.2	-	11	1454	c.1295C>G	c.(1294-1296)GCC>GGC	p.A432G	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	432	Extracellular (Potential).|Leu-rich.					chloride channel complex	chloride channel activity			ovary(3)	3						CTTCTCATAGGCGCTCTCCAG	0.627													0	0	0	0.012213	0	30	122										C	17440802	G	C	17440802	3	2	19	1	0	0	0	0	1	0	0	0	703	1203	42	4	2435	4	ANO8	19	17440802	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2085239	17440802	41688181	537	5647										
ZNF536	9745	broad.mit.edu	37	chr19	31040309	31040309	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccccagagcctggacaagccGatgaacatgctgtcggtcct	11	14	0	2	rs139373364		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:31040309G>A	uc002nsu.1	+	4	3921	c.3783G>A	c.(3781-3783)CCG>CCA	p.P1261P	ZNF536_uc010edd.1_Silent_p.P1261P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGGACAAGCCGATGAACATGC	0.597													0	0	0	0.008291	0	9	27										A	31040309	G	A	31040309	2	1	19	1	0	0	0	0	0	0	0	1	17971	1045	37	1		1	ZNF536	19	31040309	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	13599507	31040309	28088674	538	5648										
FFAR2	2867	broad.mit.edu	37	chr19	35940871	35940871	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaggtcgtctgcgccctcacGagttttggcttctacagcag	11	12	3	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:35940871G>A	uc002nzg.2	+	2	335	c.255G>A	c.(253-255)ACG>ACA	p.T85T	FFAR2_uc010eea.2_Silent_p.T85T	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	85	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCGCCCTCACGAGTTTTGGCT	0.622													0	0	0	0.00245	0	13	22										A	35940871	G	A	35940871	2	1	19	1	0	0	0	0	0	0	0	1	5828	1045	37	1		1	FFAR2	19	35940871	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4900562	35940871	23188112	539	5649										
HCST	10870	broad.mit.edu	37	chr19	36393522	36393522	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	catctgggtcacatcctcttCctgcttttgctcccaggtga	8	14	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:36393522C>T	uc002ocl.1	+	1	141	c.27C>T	c.(25-27)TTC>TTT	p.F9F	NFKBID_uc002oci.1_5'Flank|NFKBID_uc002ocj.1_5'Flank|HCST_uc002ock.1_Silent_p.F9F	NM_014266	NP_055081	Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer isoform 1	9					regulation of immune response	integral to membrane|plasma membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACATCCTCTTCCTGCTTTTGC	0.582													0	0	0	0.01441	0	174	213										T	36393522	C	T	36393522	2	4	19	1	0	0	0	0	0	0	0	1	7003	854	30	1		1	HCST	19	36393522	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	452651	36393522	22735461	540	5650										
GRIK5	2901	broad.mit.edu	37	chr19	42558025	42558025	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggatgcgcagggtgtagttGgttctctgccctttgctgtt	14	8	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:42558025G>A	uc002osj.1	-	9	1148	c.1113C>T	c.(1111-1113)ACC>ACT	p.T371T	GRIK5_uc010eib.1_Silent_p.T290T	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	371	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGGTGTAGTTGGTTCTCTGCC	0.662													0	0	0	0.005443	0	22	51										A	42558025	G	A	42558025	2	1	19	1	0	0	0	0	0	0	0	1	6777	1335	47	2		2	GRIK5	19	42558025	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	6164503	42558025	16570958	541	5651										
CEACAM8	1088	broad.mit.edu	37	chr19	43093837	43093837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gaaggccacagcatccttgtCctccacggggttggagttgt	13	11	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:43093837C>T	uc002oud.2	-	3	577	c.475G>A	c.(475-477)GAC>AAC	p.D159N	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	159	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				GCATCCTTGTCCTCCACGGGG	0.552													0	0	0	0.01441	0	86	214										T	43093837	C	T	43093837	3	4	19	1	0	0	0	0	1	0	0	0	3198	855	30	1	586	1	CEACAM8	19	43093837	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	535812	43093837	16035146	542	5652										
ERCC2	2068	broad.mit.edu	37	chr19	45860556	45860556	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agaggcagacccgtgccagcGtcatggtgaaggttgccatg	15	10	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:45860556G>A	uc002pbj.2	-	15	1498	c.1451C>T	c.(1450-1452)ACG>ATG	p.T484M	ERCC2_uc002pbh.2_Missense_Mutation_p.T47M|ERCC2_uc002pbi.2_Missense_Mutation_p.T177M|ERCC2_uc010ejz.2_Missense_Mutation_p.T406M|ERCC2_uc002pbk.2_Missense_Mutation_p.T460M	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	484	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCGTGCCAGCGTCATGGTGAA	0.652			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.010818	0	27	50										A	45860556	G	A	45860556	3	1	19	1	0	0	0	0	1	0	0	0	5213	1145	40	2	867	2	ERCC2	19	45860556	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2766719	45860556	13268427	543	5653										
SLC8A2	6543	broad.mit.edu	37	chr19	47933517	47933517	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acggcaatgcccacgaaggcGaagacggtgaagagcgtgac	15	10	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:47933517G>A	uc002pgx.2	-	10	2873	c.2595C>T	c.(2593-2595)TTC>TTT	p.F865F	SLC8A2_uc010xyq.1_Silent_p.F621F|SLC8A2_uc010xyr.1_Silent_p.F328F|SLC8A2_uc010ele.2_Missense_Mutation_p.R892C	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	865	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCACGAAGGCGAAGACGGTGA	0.726													0	0	0	0.00308	0	7	23										A	47933517	G	A	47933517	2	1	19	1	0	0	0	0	0	0	0	1	14707	1049	37	1		1	SLC8A2	19	47933517	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2072961	47933517	11195466	544	5654										
EHD2	30846	broad.mit.edu	37	chr19	48229178	48229178	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacgagttctcagaggccatCggcgcgttgcggggccatga	16	11	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:48229178C>T	uc002phj.3	+	4	862	c.612C>T	c.(610-612)ATC>ATT	p.I204I	EHD2_uc010xyu.1_Silent_p.I68I|EHD2_uc010xyv.1_5'Flank	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	204					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		CAGAGGCCATCGGCGCGTTGC	0.637													0	0	0	0.012319	0	19	32										T	48229178	C	T	48229178	2	4	19	1	0	0	0	0	0	0	0	1	4978	874	31	1		1	EHD2	19	48229178	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	295661	48229178	10899805	545	5655										
RASIP1	54922	broad.mit.edu	37	chr19	49238513	49238513	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cggttgctgggggcctggatGaggcactgagtcaactgatc	16	9	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49238513G>A	uc002pki.2	-	4	1316	c.1119C>T	c.(1117-1119)CTC>CTT	p.L373L		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	373					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GGGCCTGGATGAGGCACTGAG	0.667													0	0	0	0.004656	0	19	59										A	49238513	G	A	49238513	2	1	19	1	0	0	0	0	0	0	0	1	13078	1277	45	1		1	RASIP1	19	49238513	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1009335	49238513	9890470	546	5656										
PPP1R15A	23645	broad.mit.edu	37	chr19	49379181	49379181	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgtggccacaccttcccgctCgtctgctgctgcagcggctg	12	16	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49379181C>T	uc002pky.3	+	3	2245	c.1976C>T	c.(1975-1977)TCG>TTG	p.S659L		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	659					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CCTTCCCGCTCGTCTGCTGCT	0.567													0	0	0	0.01441	0	82	169										T	49379181	C	T	49379181	3	4	19	1	0	0	0	0	1	0	0	0	12363	893	31	1	1982	1	PPP1R15A	19	49379181	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	140668	49379181	9749802	547	5657										
GYS1	2997	broad.mit.edu	37	chr19	49473902	49473902	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgctgacagaaactgtagagGaaggaggtgagctgcgagca	16	6	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49473902G>T	uc002plp.2	-	14	1951	c.1710C>A	c.(1708-1710)TTC>TTA	p.F570L	GYS1_uc010xzy.1_Missense_Mutation_p.F203L|GYS1_uc010emm.2_Missense_Mutation_p.F506L|GYS1_uc010xzz.1_Missense_Mutation_p.F490L	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	570					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		AACTGTAGAGGAAGGAGGTGA	0.592											OREG0025611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.35188e-11	0.006122	2.47329e-11	17	58										T	49473902	G	T	49473902	3	4	19	1	0	0	0	0	1	0	0	0	6912	1165	41	3	515	3	GYS1	19	49473902	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	94721	49473902	9655081	548	5658										
HRC	3270	broad.mit.edu	37	chr19	49658061	49658061	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggtggtgcctgtgctcagctGagtcttccgtgtcttcactc	12	12	4	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49658061G>C	uc002pmv.2	-	1	621	c.434C>G	c.(433-435)TCA>TGA	p.S145*	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	145	4 X tandem repeats, acidic.|6 X approximate tandem repeats.|2-2.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GTGCTCAGCTGAGTCTTCCGT	0.582													0	0	0	0.00874	0	44	110										C	49658061	G	C	49658061	4	2	19	1	0	0	0	0	0	1	0	0	7352	1294	45	1	1689	1	HRC	19	49658061	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	184159	49658061	9470922	549	5659										
KLK2	3817	broad.mit.edu	37	chr19	51381756	51381756	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcctgaaaagcctgctgtgTacaccaaggtggtgcattac	11	10	0	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:51381756T>C	uc002ptv.2	+	5	768	c.727T>C	c.(727-729)TAC>CAC	p.Y243H	KLK2_uc002ptu.2_3'UTR|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Missense_Mutation_p.Y226H|KLK2_uc010ycm.1_Missense_Mutation_p.Y141H|KLK2_uc010eoh.2_Missense_Mutation_p.Y141H	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	243	Peptidase S1.				proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		GCCTGCTGTGTACACCAAGGT	0.537			T	ETV4	prostate								0	0	0	0.01441	0	124	266										C	51381756	T	C	51381756	3	2	19	1	0	0	0	0	1	0	0	0	8404	1638	57	5	782	5	KLK2	19	51381756	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	1723695	51381756	7747227	550	5660										
KLK8	11202	broad.mit.edu	37	chr19	51499316	51499316	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctagtgcttatcctagaatCagcccttgctgcctatgatc	7	12	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:51499316C>T	uc002pur.1	-	6	961	c.782G>A	c.(781-783)TGA>TAA	p.*261*	KLK8_uc002puq.1_Silent_p.*306*|KLK8_uc002pus.1_Silent_p.*120*|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Silent_p.*261*|KLK9_uc002puv.1_RNA	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	261					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		ATCCTAGAATCAGCCCTTGCT	0.537													0	0	0	0.01441	0	100	245										T	51499316	C	T	51499316	2	4	19	1	0	0	0	0	0	0	0	1	8410	837	29	1		1	KLK8	19	51499316	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	117560	51499316	7629667	551	5661										
ZNF160	90338	broad.mit.edu	37	chr19	53572357	53572357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgcatttgaaaggttttgttCcagtatggatgacctgatgg	12	5	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:53572357C>T	uc010eqk.2	-	7	1846	c.1430G>A	c.(1429-1431)GGA>GAA	p.G477E	ZNF160_uc002qaq.3_Missense_Mutation_p.G477E|ZNF160_uc002qar.3_Missense_Mutation_p.G477E	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	477					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AGGTTTTGTTCCAGTATGGAT	0.398													0	0	0	0.009718	0	36	84										T	53572357	C	T	53572357	3	4	19	1	0	0	0	0	1	0	0	0	17736	855	30	1	1030	1	ZNF160	19	53572357	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	2073041	53572357	5556626	552	5662										
LILRA2	11027	broad.mit.edu	37	chr19	55087422	55087422	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggccatcccccactgcatctGagatcagagcaccaagctca	8	16	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:55087422G>T	uc002qgg.3	+	6	1190	c.1101G>T	c.(1099-1101)CTG>CTT	p.L367L	LILRA2_uc010ern.2_Silent_p.L367L|LILRA2_uc002qgf.2_Silent_p.L367L|LILRA2_uc010yfe.1_Silent_p.L367L|LILRA2_uc010yff.1_Silent_p.L355L|LILRA2_uc010ero.2_Silent_p.L355L|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	367	Ig-like C2-type 4.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CACTGCATCTGAGATCAGAGC	0.587													1	0	1.15919e-05	0.008871	1.19092e-05	19	122										T	55087422	G	T	55087422	2	4	19	1	0	0	0	0	0	0	0	1	8785	1277	45	3		3	LILRA2	19	55087422	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1515065	55087422	4041561	553	5663										
NLRP4	147945	broad.mit.edu	37	chr19	56369129	56369129	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctgagattcacctatactttGaggaggaagtcaagcaagaa	10	7	2	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:56369129G>A	uc002qmd.3	+	3	792	c.370G>A	c.(370-372)GAG>AAG	p.E124K	NLRP4_uc002qmf.2_Missense_Mutation_p.E49K|NLRP4_uc010etf.2_5'UTR	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	124							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCTATACTTTGAGGAGGAAGT	0.473													0	0	0	0.009718	0	34	69										A	56369129	G	A	56369129	3	1	19	1	0	0	0	0	1	0	0	0	10479	1291	45	1	376	1	NLRP4	19	56369129	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1281707	56369129	2759854	554	5664										
NLRP5	126206	broad.mit.edu	37	chr19	56538546	56538546	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccagggaatgttctcctacgTcttcttcctccccgttagag	8	14	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:56538546T>A	uc002qmj.2	+	7	947	c.947T>A	c.(946-948)GTC>GAC	p.V316D	NLRP5_uc002qmi.2_Missense_Mutation_p.V297D	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	316	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTCTCCTACGTCTTCTTCCTC	0.567													0	0	0	0.004482	0	8	14										A	56538546	T	A	56538546	3	1	19	1	0	0	0	0	1	0	0	0	10480	1667	58	5	973	5	NLRP5	19	56538546	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	169417	56538546	2590437	555	5665										
ZNF134	7693	broad.mit.edu	37	chr19	58131977	58131977	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggaagacacacaggagcactGagagtggggatgcatttcat	14	7	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:58131977G>C	uc002qpn.2	+	3	589	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	ZNF134_uc002qpo.2_5'UTR|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	164						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAGGAGCACTGAGAGTGGGGA	0.488													0	0	0	0.00333	0	22	35										C	58131977	G	C	58131977	3	2	19	1	0	0	0	0	1	0	0	0	17721	1291	45	1	496	1	ZNF134	19	58131977	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1593431	58131977	997006	556	5666										
ZNF324	25799	broad.mit.edu	37	chr19	58982235	58982235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	taaaaagcctgcagagacaaCggggtgcctccccatctcgg	11	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:58982235C>T	uc002qsw.1	+	4	470	c.376C>T	c.(376-378)CGG>TGG	p.R126W	ZNF324_uc002qsx.1_5'Flank	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGAGACAACGGGGTGCCTC	0.602													0	0	0	0.01441	0	50	109										T	58982235	C	T	58982235	3	4	19	1	0	0	0	0	1	0	0	0	17841	527	19	2	386	2	ZNF324	19	58982235	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	850258	58982235	146748	557	5667										
CSNK2A1	1457	broad.mit.edu	37	chr20	470507	470507	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	acaacccaaactccacatatCcaaactataatcgtacatct	1	14	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:470507C>A	uc002wdw.1	-	10	1033	c.640G>T	c.(640-642)GAT>TAT	p.D214Y	CSNK2A1_uc002wdx.1_Missense_Mutation_p.D214Y|CSNK2A1_uc002wdy.1_Missense_Mutation_p.D78Y	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	214	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CTCCACATATCCAAACTATAA	0.323													1	0	3.62473e-10	0.012319	3.78394e-10	21	51										A	470507	C	A	470507	3	1	19	1	0	0	0	0	1	0	0	0	3957	855	30	3	555	3	CSNK2A1	20	470507	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		470507	62555013	558	5668										
SRXN1	140809	broad.mit.edu	37	chr20	629543	629543	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ccagaggacatcgatgggggGcacgctgtctgggtcctcct	15	12	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:629543G>T	uc002wea.2	-	2	290	c.229C>A	c.(229-231)CCC>ACC	p.P77T	SRXN1_uc002web.2_RNA	NM_080725	NP_542763	Q9BYN0	SRXN1_HUMAN	sulfiredoxin 1 homolog	77					response to oxidative stress	cytosol	antioxidant activity|ATP binding|DNA binding|sulfiredoxin activity			ovary(1)	1						TCGATGGGGGGCACGCTGTCT	0.577													1	0	2.17888e-05	0.006214	2.23531e-05	9	40										T	629543	G	T	629543	3	4	19	1	0	0	0	0	1	0	0	0	15172	1203	42	4	188	4	SRXN1	20	629543	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	159036	629543	62395977	559	5669										
VPS16	64601	broad.mit.edu	37	chr20	2844876	2844876	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggtaccccttctcctaaagAtgaagaggagcaaactggca	10	10	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:2844876A>G	uc002whe.2	+	17	1711	c.1663A>G	c.(1663-1665)ATG>GTG	p.M555V	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'UTR|VPS16_uc002whf.2_Missense_Mutation_p.M411V|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.M241V|VPS16_uc002whi.2_Missense_Mutation_p.M39V	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	555					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TCTCCTAAAGATGAAGAGGAG	0.617													0	0	0	0.012213	0	26	86										G	2844876	A	G	2844876	3	3	19	1	0	0	0	0	1	0	0	0	17190	333	12	5	1729	5	VPS16	20	2844876	Missense_Mutation	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2215333	2844876	60180644	560	5670										
PANK2	80025	broad.mit.edu	37	chr20	3869809	3869809	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcgccgccatcactctcttCtgggctacaccgccttctct	8	18	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:3869809C>T	uc002wkc.2	+	1	68	c.62C>T	c.(61-63)TCT>TTT	p.S21F	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	21					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TCACTCTCTTCTGGGCTACAC	0.677													0	0	0	0.006122	0	19	14										T	3869809	C	T	3869809	3	4	19	1	0	0	0	0	1	0	0	0	11417	913	32	1	64	1	PANK2	20	3869809	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1024933	3869809	59155711	561	5671										
TRMT6	51605	broad.mit.edu	37	chr20	5924896	5924896	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttcaattaactgctgaactaTttcctataagaaaaggagca	6	7	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:5924896T>A	uc002wmh.1	-	4	492	c.370A>T	c.(370-372)ATA>TTA	p.I124L	TRMT6_uc010zra.1_5'UTR|TRMT6_uc010gbn.1_5'UTR|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	124					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						TGCTGAACTATTTCCTATAAG	0.308													0	0	0	0.003163	0	12	17										A	5924896	T	A	5924896	3	1	19	1	0	0	0	0	1	0	0	0	16565	1493	52	5	1155	5	TRMT6	20	5924896	Missense_Mutation	SNP	T	TCGA-BT-A3PJ-01A-21D-A21Z-08	2055087	5924896	57100624	562	5672										
PLCB4	5332	broad.mit.edu	37	chr20	9288501	9288501	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttaactggcagaaggaagttCcctcctttttgcaagaagga	10	8	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:9288501C>T	uc002wnf.2	+	3	176	c.40C>T	c.(40-42)CCC>TCC	p.P14S	PLCB4_uc010gbw.1_Missense_Mutation_p.P14S|PLCB4_uc010gbx.2_Missense_Mutation_p.P14S|PLCB4_uc002wne.2_Missense_Mutation_p.P14S	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	14					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GAAGGAAGTTCCCTCCTTTTT	0.299													0	0	0	0.004007	0	12	28										T	9288501	C	T	9288501	3	4	19	1	0	0	0	0	1	0	0	0	12030	855	30	1	42	1	PLCB4	20	9288501	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3363605	9288501	53737019	563	5673										
CRNKL1	51340	broad.mit.edu	37	chr20	20023021	20023021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tgatccaaagataaatgtagCgcttccagtgcctcttctcc	7	12	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:20023021C>T	uc002wrs.2	-	9	1627	c.1595G>A	c.(1594-1596)CGC>CAC	p.R532H		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	532	HAT 9.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						ATAAATGTAGCGCTTCCAGTG	0.448													0	0	0	0.01441	0	48	75										T	20023021	C	T	20023021	3	4	19	1	0	0	0	0	1	0	0	0	3891	768	27	2	979	2	CRNKL1	20	20023021	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	10734520	20023021	43002499	564	5674										
ABHD12	26090	broad.mit.edu	37	chr20	25297683	25297683	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtgggtgctgcctgcactcaCcttgtaaagctccacgcggt	12	13	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:25297683C>A	uc002wus.1	-	5	711	c.573_splice	c.e5+1	p.K191_splice	ABHD12_uc002wuq.2_Splice_Site_p.K191_splice|ABHD12_uc002wur.2_Splice_Site_p.K191_splice|ABHD12_uc002wut.1_Splice_Site_p.K191_splice|ABHD12_uc002wuu.1_Splice_Site	NM_001042472	NP_001035937	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform a							integral to membrane	acylglycerol lipase activity			skin(1)	1						CCTGCACTCACCTTGTAAAGC	0.547													1	0	2.40579e-17	0.00623	2.57171e-17	31	55										A	25297683	C	A	25297683	5	1	19	1	0	0	0	0	0	0	1	0	76	521	18	4	720	4	ABHD12	20	25297683	Splice_Site	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5274662	25297683	37727837	565	5675										
XKR7	343702	broad.mit.edu	37	chr20	30584822	30584822	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggcatattcttcatgtgtgtCtactactgtctcctgcaccc	7	13	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:30584822C>T	uc002wxe.2	+	3	1476	c.1302C>T	c.(1300-1302)GTC>GTT	p.V434V		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	434	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATGTGTGTCTACTACTGTC	0.587													0	0	0	0.00632	0	25	103										T	30584822	C	T	30584822	2	4	19	1	0	0	0	0	0	0	0	1	17433	900	32	1		1	XKR7	20	30584822	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	5287139	30584822	32440698	566	5676										
KIF3B	9371	broad.mit.edu	37	chr20	30897794	30897794	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ggaatgccaagcagtttgaaCtgtacgatgagacgttccga	12	8	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:30897794C>T	uc002wxq.2	+	2	381	c.214C>T	c.(214-216)CTG>TTG	p.L72L	KIF3B_uc010ztv.1_Silent_p.L72L|KIF3B_uc010ztw.1_Silent_p.L72L	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	72	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCAGTTTGAACTGTACGATGA	0.498													0	0	0	0.010729	0	8	81										T	30897794	C	T	30897794	2	4	19	1	0	0	0	0	0	0	0	1	8301	564	20	2		2	KIF3B	20	30897794	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	312972	30897794	32127726	567	5677										
TOMM34	10953	broad.mit.edu	37	chr20	43580587	43580587	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaacaggcaccaaggggattGagggcagcttcaggcgccac	14	11	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:43580587G>A	uc002xmy.2	-	4	577	c.437C>T	c.(436-438)TCA>TTA	p.S146L	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	146					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				CAAGGGGATTGAGGGCAGCTT	0.527													0	0	0	0.009718	0	40	172										A	43580587	G	A	43580587	3	1	19	1	0	0	0	0	1	0	0	0	16354	1294	45	1	508	1	TOMM34	20	43580587	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	12682793	43580587	19444933	568	5678										
MATN4	8785	broad.mit.edu	37	chr20	43927050	43927050	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtagcgacccagagggaactCggtgcgcacgcggctcgaga	16	12	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:43927050C>T	uc002xnn.2	-	7	1373	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	MATN4_uc002xno.2_Missense_Mutation_p.E355K|MATN4_uc002xnp.2_Missense_Mutation_p.E314K|MATN4_uc010zwr.1_Missense_Mutation_p.E344K|MATN4_uc002xnr.1_Missense_Mutation_p.E396K	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	437	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AGAGGGAACTCGGTGCGCACG	0.657													0	0	0	0.01441	0	93	64										T	43927050	C	T	43927050	3	4	19	1	0	0	0	0	1	0	0	0	9336	893	31	1	575	1	MATN4	20	43927050	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	346463	43927050	19098470	569	5679										
TNNC2	7125	broad.mit.edu	37	chr20	44453014	44453014	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atctggcgcaccatcatgacCaagaactcctcgaagtcgat	8	13	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:44453014C>T	uc002xpr.2	-	4	297	c.231G>A	c.(229-231)TTG>TTA	p.L77L		NM_003279	NP_003270	P02585	TNNC2_HUMAN	fast skeletal muscle troponin C	77	EF-hand 2.				muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(115;0.0122)				CCATCATGACCAAGAACTCCT	0.662													0	0	0	0.003271	0	31	168										T	44453014	C	T	44453014	2	4	19	1	0	0	0	0	0	0	0	1	16322	593	21	2		2	TNNC2	20	44453014	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	525964	44453014	18572506	570	5680										
NCOA3	8202	broad.mit.edu	37	chr20	46254142	46254142	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caggaaaaactatttccaatGatgatgatgttcaaaaagcc	7	7	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:46254142G>A	uc002xtk.2	+	5	479	c.274G>A	c.(274-276)GAT>AAT	p.D92N	NCOA3_uc010ght.1_Missense_Mutation_p.D92N|NCOA3_uc002xtl.2_Missense_Mutation_p.D92N|NCOA3_uc002xtm.2_Missense_Mutation_p.D92N|NCOA3_uc002xtn.2_Missense_Mutation_p.D92N|NCOA3_uc010zyc.1_5'Flank	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	92					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TATTTCCAATGATGATGATGT	0.368													0	0	0	0.01441	0	54	39										A	46254142	G	A	46254142	3	1	19	1	0	0	0	0	1	0	0	0	10230	1290	45	1	284	1	NCOA3	20	46254142	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	1801128	46254142	16771378	571	5681										
ZNF217	7764	broad.mit.edu	37	chr20	52199147	52199147	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aggtcttctgaatgtgtgaaGgtctggctgcagaacatgca	13	7	3	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:52199147G>A	uc002xwq.3	-	1	490	c.219C>T	c.(217-219)ACC>ACT	p.T73T	ZNF217_uc010gij.1_Silent_p.T65T	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	73	C2H2-type 1.				negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			AATGTGTGAAGGTCTGGCTGC	0.463													0	0	0	0.009718	0	42	96										A	52199147	G	A	52199147	2	1	19	1	0	0	0	0	0	0	0	1	17769	987	35	2		2	ZNF217	20	52199147	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5945005	52199147	10826373	572	5682										
SYNJ1	8867	broad.mit.edu	37	chr21	34022588	34022588	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atgctaattttctctaaactCatttcttcttccaaattttt	1	9	4	0	rs115683257	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:34022588C>G	uc002yqh.2	-	23	3060	c.3060G>C	c.(3058-3060)ATG>ATC	p.M1020I	SYNJ1_uc011ads.1_Missense_Mutation_p.M976I|SYNJ1_uc002yqf.2_Missense_Mutation_p.M981I|SYNJ1_uc002yqg.2_Missense_Mutation_p.M976I|SYNJ1_uc002yqi.2_Missense_Mutation_p.M1020I	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	981	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						TCTCTAAACTCATTTCTTCTT	0.353													0	0	0	0.01441	0	39	80										G	34022588	C	G	34022588	3	3	19	1	0	0	0	0	1	0	0	0	15449	826	29	1	1843	1	SYNJ1	21	34022588	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08		34022588	14107307	573	5683										
MORC3	23515	broad.mit.edu	37	chr21	37744784	37744784	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gacggcaacagatgtttcaaCatcaagtaacattgaggagt	10	7	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:37744784C>A	uc002yvi.2	+	16	2697	c.2621C>A	c.(2620-2622)ACA>AAA	p.T874K		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	874	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GATGTTTCAACATCAAGTAAC	0.358													1	0	1.5739e-10	0.004007	1.64785e-10	13	47										A	37744784	C	A	37744784	3	1	19	1	0	0	0	0	1	0	0	0	9703	478	17	4	2683	4	MORC3	21	37744784	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3722196	37744784	10385111	574	5684										
KCNJ15	3772	broad.mit.edu	37	chr21	39671488	39671488	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agaacccggtgagcccatttCaaatcataccccctgcatca	6	15	3	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:39671488C>G	uc002ywv.2	+	4	607	c.305C>G	c.(304-306)TCA>TGA	p.S102*	KCNJ15_uc002yww.2_Nonsense_Mutation_p.S102*|KCNJ15_uc002ywx.2_Nonsense_Mutation_p.S102*	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	102	Extracellular (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						GAGCCCATTTCAAATCATACC	0.493													0	0	0	0.01441	0	52	69										G	39671488	C	G	39671488	4	3	19	1	0	0	0	0	0	1	0	0	8049	838	29	1	307	1	KCNJ15	21	39671488	Nonsense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	1926704	39671488	8458407	575	5685										
ERG	2078	broad.mit.edu	37	chr21	39755585	39755585	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctggagggcctgggcgatccCgtggaagtcgaacttgtagg	17	9	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:39755585C>A	uc010gnw.2	-	12	1496	c.1201G>T	c.(1201-1203)GGG>TGG	p.G401W	ERG_uc002yxa.2_Missense_Mutation_p.G394W|ERG_uc011aek.1_Missense_Mutation_p.G302W|ERG_uc010gnv.2_Missense_Mutation_p.G278W|ERG_uc010gnx.2_Missense_Mutation_p.G377W|ERG_uc011ael.1_Missense_Mutation_p.G401W|ERG_uc002yxb.2_Missense_Mutation_p.G377W	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	401					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				TGGGCGATCCCGTGGAAGTCG	0.582													1	0	1.2582e-26	0.01441	1.3613e-26	56	98										A	39755585	C	A	39755585	3	1	19	1	0	0	0	0	1	0	0	0	5222	652	23	4	263	4	ERG	21	39755585	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	84097	39755585	8374310	576	5686										
BRWD1	54014	broad.mit.edu	37	chr21	40590434	40590434	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	aaaaataaaaaacttaccaaGattcaaaagttgatctatac	3	6	2	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:40590434G>T	uc002yxk.1	-	30	3674	c.3535C>A	c.(3535-3537)CTT>ATT	p.L1179I	BRWD1_uc010goc.1_Intron|BRWD1_uc002yxl.2_Missense_Mutation_p.L1179I|BRWD1_uc010god.1_Missense_Mutation_p.L145I	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1179	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AACTTACCAAGATTCAAAAGT	0.284													1	0	5.18039e-06	0.00308	5.3299e-06	6	27										T	40590434	G	T	40590434	3	4	19	1	0	0	0	0	1	0	0	0	1525	942	33	3	3718	3	BRWD1	21	40590434	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	834849	40590434	7539461	577	5687										
TMPRSS2	7113	broad.mit.edu	37	chr21	42840425	42840425	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttgcatctctgtgtctcaatGagaagcaccttggcagcgtt	10	10	2	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:42840425G>A	uc002yzj.2	-	12	1346	c.1212C>T	c.(1210-1212)CTC>CTT	p.L404L	TMPRSS2_uc010gor.2_Silent_p.L441L|TMPRSS2_uc010gos.1_Silent_p.L404L	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	404	Peptidase S1.|Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GTGTCTCAATGAGAAGCACCT	0.542			T	ERG|ETV1|ETV4|ETV5	prostate 								0	0	0	0.007291	0	29	45										A	42840425	G	A	42840425	2	1	19	1	0	0	0	0	0	0	0	1	16244	1277	45	1		1	TMPRSS2	21	42840425	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2249991	42840425	5289470	578	5688										
PCNT	5116	broad.mit.edu	37	chr21	47746353	47746353	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cattcggagaaaaagacggcGaagaggaagggctcggctgt	16	7	0	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:47746353G>A	uc002zji.3	+	2	224	c.117G>A	c.(115-117)GCG>GCA	p.A39A	PCNT_uc002zjj.2_5'UTR|C21orf58_uc011afx.1_5'Flank|C21orf58_uc002zjf.2_5'Flank|C21orf58_uc010gqj.1_5'Flank|C21orf58_uc002zjg.1_5'Flank	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	39					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AAAAGACGGCGAAGAGGAAGG	0.507													0	0	0	0.009535	0	28	53										A	47746353	G	A	47746353	2	1	19	1	0	0	0	0	0	0	0	1	11590	1045	37	1		1	PCNT	21	47746353	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4905928	47746353	383542	579	5689										
PCNT	5116	broad.mit.edu	37	chr21	47858172	47858172	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ctcagcacggtgacccaggaGaagctggagctgagcagagc	15	11	1	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:47858172G>A	uc002zji.3	+	41	9302	c.9195G>A	c.(9193-9195)GAG>GAA	p.E3065E	PCNT_uc002zjj.2_Silent_p.E2868E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3065	Interaction with NEK2.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGACCCAGGAGAAGCTGGAGC	0.527													0	0	0	0.006214	0	8	61										A	47858172	G	A	47858172	2	1	19	1	0	0	0	0	0	0	0	1	11590	933	33	1		1	PCNT	21	47858172	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	111819	47858172	271723	580	5690										
CABIN1	23523	broad.mit.edu	37	chr22	24479187	24479187	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctgcccaccacaggtgcgaGtactccagaaggaactggct	11	13	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:24479187G>A	uc002zzi.1	+	20	2882	c.2755G>A	c.(2755-2757)GTA>ATA	p.V919I	CABIN1_uc002zzj.1_Missense_Mutation_p.V869I|CABIN1_uc002zzl.1_Missense_Mutation_p.V919I	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	919					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACAGGTGCGAGTACTCCAGAA	0.582													0	0	0	0.009096	0	3	68										A	24479187	G	A	24479187	3	1	19	1	0	0	0	0	1	0	0	0	2528	1029	36	2	2829	2	CABIN1	22	24479187	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08		24479187	26825379	581	5691										
AP1B1	162	broad.mit.edu	37	chr22	29745219	29745219	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tggctcacctgtgtgctctcGtcatggaagccctcgaggaa	12	12	3	0	rs144812422		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:29745219G>C	uc003afj.2	-	11	1609	c.1425C>G	c.(1423-1425)GAC>GAG	p.D475E	AP1B1_uc003afi.2_Missense_Mutation_p.D475E|AP1B1_uc003afk.2_Missense_Mutation_p.D475E|AP1B1_uc003afl.2_Missense_Mutation_p.D475E|AP1B1_uc011ako.1_Missense_Mutation_p.D28E	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	475					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GTGTGCTCTCGTCATGGAAGC	0.612													0	0	0	0.01441	0	46	110										C	29745219	G	C	29745219	3	2	19	1	0	0	0	0	1	0	0	0	731	1136	40	4	1476	4	AP1B1	22	29745219	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	5266032	29745219	21559347	582	5692										
SYN3	8224	broad.mit.edu	37	chr22	33264982	33264982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	cttgctgcagaagttgtagaCggagtagagagagttgacag	15	5	0	5	rs77543787	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:33264982C>T	uc003amx.2	-	4	751	c.592G>A	c.(592-594)GTC>ATC	p.V198I	SYN3_uc003amy.2_Missense_Mutation_p.V198I|SYN3_uc003amz.2_Missense_Mutation_p.V197I	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	198	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						AAGTTGTAGACGGAGTAGAGA	0.632													0	0	0	0.014323	0	19	40										T	33264982	C	T	33264982	3	4	19	1	0	0	0	0	1	0	0	0	15439	536	19	2	1190	2	SYN3	22	33264982	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	3519763	33264982	18039584	583	5693										
GGA1	26088	broad.mit.edu	37	chr22	38014472	38014472	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caggtgctggaaacatgcatGaagagctgcggcaagcggtt	15	8	0	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:38014472G>C	uc003atc.2	+	4	587	c.222G>C	c.(220-222)ATG>ATC	p.M74I	GGA1_uc003atd.2_Missense_Mutation_p.M74I|GGA1_uc003ate.2_Missense_Mutation_p.M74I|GGA1_uc003atf.2_Missense_Mutation_p.M1I	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	74	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					AAACATGCATGAAGAGCTGCG	0.637													0	0	0	0.014323	0	18	70										C	38014472	G	C	38014472	3	2	19	1	0	0	0	0	1	0	0	0	6352	1290	45	1	302	1	GGA1	22	38014472	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	4749490	38014472	13290094	584	5694										
TNRC6B	23112	broad.mit.edu	37	chr22	40711471	40711471	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcagcacagcaccccgatcAgtcagggggtgggggacaca	15	12	2	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:40711471A>T	uc011aor.1	+	20	5074	c.4863A>T	c.(4861-4863)TCA>TCT	p.S1621S	TNRC6B_uc003aym.2_Silent_p.S817S|TNRC6B_uc003ayn.3_Silent_p.S1511S|TNRC6B_uc003ayo.2_Silent_p.S1368S	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1621					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						CACCCCGATCAGTCAGGGGGT	0.582													0	0	0	0.01441	0	39	147										T	40711471	A	T	40711471	2	4	19	1	0	0	0	0	0	0	0	1	16338	175	7	5		5	TNRC6B	22	40711471	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08	2696999	40711471	10593095	585	5695										
PRR5-ARHGAP8	553158	broad.mit.edu	37	chr22	45198028	45198028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caccctcccacgagctggacCaccagcggctgctggagtaa	11	16	0	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:45198028C>T	uc003bfd.2	+	9	1185	c.913C>T	c.(913-915)CAC>TAC	p.H305Y	PRR5-ARHGAP8_uc003bfc.2_Missense_Mutation_p.H182Y|PRR5-ARHGAP8_uc011aqi.1_Missense_Mutation_p.H173Y|PRR5-ARHGAP8_uc011aqj.1_Missense_Mutation_p.H87Y|ARHGAP8_uc003bfi.2_Missense_Mutation_p.H51Y|ARHGAP8_uc010gzv.2_Missense_Mutation_p.H51Y|ARHGAP8_uc003bfj.2_Missense_Mutation_p.H51Y|ARHGAP8_uc003bfk.2_Missense_Mutation_p.H51Y|ARHGAP8_uc003bfl.2_Intron|PRR5-ARHGAP8_uc003bfg.1_Missense_Mutation_p.H87Y	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						CGAGCTGGACCACCAGCGGCT	0.597													0	0	0	0.010729	0	11	72										T	45198028	C	T	45198028	3	4	19	1	0	0	0	0	1	0	0	0	12601	594	21	2	539	2	PRR5-ARHGAP8	22	45198028	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	4486557	45198028	6106538	586	5696										
PRRG1	5638	broad.mit.edu	37	chrX	37312442	37312442	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	caaggggagagtaaccgaggAagtgactggtttcagtttta	14	5	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:37312442A>T	uc004ddn.2	+	5	478	c.225A>T	c.(223-225)GGA>GGT	p.G75G	PRRG1_uc004ddo.2_Silent_p.G75G	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	75	Extracellular (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						GTAACCGAGGAAGTGACTGGT	0.373													0	0	0	0.009535	0	27	9										T	37312442	A	T	37312442	2	4	19	1	0	0	0	0	0	0	0	1	12605	233	9	5		5	PRRG1	23	37312442	Silent	SNP	A	TCGA-BT-A3PJ-01A-21D-A21Z-08		37312442	117958118	587	5697										
CACNA1F	778	broad.mit.edu	37	chrX	49079027	49079027	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	atctccactggccaggttgtCcacagcaatggcaagaaaca	9	12	1	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:49079027C>T	uc004dnb.2	-	17	2337	c.2275G>A	c.(2275-2277)GAC>AAC	p.D759N	CACNA1F_uc010nip.2_Missense_Mutation_p.D748N	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	759	II.|Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GCCAGGTTGTCCACAGCAATG	0.562													0	0	0	0.010818	0	25	18										T	49079027	C	T	49079027	3	4	19	1	0	0	0	0	1	0	0	0	2543	855	30	1	3786	1	CACNA1F	23	49079027	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	11766585	49079027	106191533	588	5698										
HDAC8	55869	broad.mit.edu	37	chrX	71792545	71792545	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	gtcacacatactgacatactCgggactatagatataaaccg	7	10	1	2			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:71792545C>T	uc004eau.2	-	1	109	c.67G>A	c.(67-69)GAG>AAG	p.E23K	HDAC8_uc011mqf.1_5'UTR|HDAC8_uc011mqg.1_Missense_Mutation_p.E23K|HDAC8_uc011mqh.1_Missense_Mutation_p.E23K|HDAC8_uc010nlk.1_5'UTR|HDAC8_uc004eav.2_Missense_Mutation_p.E23K|HDAC8_uc004eaw.2_RNA	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	23	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	CTGACATACTCGGGACTATAG	0.592													0	0	0	0.01441	0	68	42										T	71792545	C	T	71792545	3	4	19	1	0	0	0	0	1	0	0	0	7013	893	31	1	1196	1	HDAC8	23	71792545	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	22713518	71792545	83478015	589	5699										
PCDH19	57526	broad.mit.edu	37	chrX	99661763	99661763	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	tctatttcaaagaagccgcgGtcgccctcggtcatgtcgta	10	12	3	1			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:99661763G>A	uc010nmz.2	-	1	3509	c.1833C>T	c.(1831-1833)GAC>GAT	p.D611D	PCDH19_uc004efw.3_Silent_p.D611D|PCDH19_uc004efx.3_Silent_p.D611D	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	611	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AGAAGCCGCGGTCGCCCTCGG	0.567													0	0	0	0.004482	0	8	58										A	99661763	G	A	99661763	2	1	19	1	0	0	0	0	0	0	0	1	11514	1252	44	2		2	PCDH19	23	99661763	Silent	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	27869218	99661763	55608797	590	5700										
AMOT	154796	broad.mit.edu	37	chrX	112033995	112033995	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	ttctgaaacgttggtgggctGacagttgccctgacgctgtt	13	9	1	3			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:112033995G>A	uc004epr.2	-	7	1942	c.1942C>T	c.(1942-1944)CAG>TAG	p.Q648*	AMOT_uc004eps.2_Nonsense_Mutation_p.Q239*	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	648	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TTGGTGGGCTGACAGTTGCCC	0.512													0	0	0	0.010771	0	39	29										A	112033995	G	A	112033995	4	1	19	1	0	0	0	0	0	1	0	0	582	1299	45	1	1332	1	AMOT	23	112033995	Nonsense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	12372232	112033995	43236565	591	5701										
DDX26B	203522	broad.mit.edu	37	chrX	134709105	134709105	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agagattgatccagaccaacCcaaaagactgcatacttttg	7	10	0	4			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:134709105C>T	uc004eyw.3	+	13	2090	c.1727C>T	c.(1726-1728)CCC>CTC	p.P576L	DDX26B_uc004eyx.3_Missense_Mutation_p.P177L	NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	576											0	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGACCAACCCAAAAGACTG	0.403													0	0	0	0.01441	0	59	29										T	134709105	C	T	134709105	3	4	19	1	0	0	0	0	1	0	0	0	4353	623	22	2	1777	2	DDX26B	23	134709105	Missense_Mutation	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	22675110	134709105	20561455	592	5702										
CNGA2	1260	broad.mit.edu	37	chrX	150911821	150911821	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agcaaccttgtcctctacatCttggtcatcatccactggaa	6	13	4	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:150911821C>T	uc004fey.1	+	7	1070	c.846C>T	c.(844-846)ATC>ATT	p.I282I		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	282	Helical; Name=H4; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTACATCTTGGTCATCA	0.507													0	0	0	0.01441	0	90	48										T	150911821	C	T	150911821	2	4	19	1	0	0	0	0	0	0	0	1	3597	903	32	1		1	CNGA2	23	150911821	Silent	SNP	C	TCGA-BT-A3PJ-01A-21D-A21Z-08	16202716	150911821	4358739	593	5703										
PDZD4	57595	broad.mit.edu	37	chrX	153069709	153069709	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.400337837837838	237	2.48426785224429e-72	3.50689809778614	4.56253487513628	3.08529703190946	7.05394479640587e-08	8.33648021393421e-07	169	agctctccccagtgttgtagGcgctggtgctgtccttgtcc	12	13	1	0			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:153069709G>A	uc004fiz.1	-	8	1659	c.1409C>T	c.(1408-1410)GCC>GTC	p.A470V	PDZD4_uc004fiy.1_Missense_Mutation_p.A395V|PDZD4_uc004fix.2_Missense_Mutation_p.A374V|PDZD4_uc004fja.1_Missense_Mutation_p.A476V|PDZD4_uc011mze.1_Missense_Mutation_p.A361V	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	470						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTGTTGTAGGCGCTGGTGCT	0.672													0	0	0	0.00333	0	23	11										A	153069709	G	A	153069709	3	1	19	1	0	0	0	0	1	0	0	0	11703	1203	42	2	904	2	PDZD4	23	153069709	Missense_Mutation	SNP	G	TCGA-BT-A3PJ-01A-21D-A21Z-08	2157888	153069709	2200851	594	5704										
MRPL20	55052	broad.mit.edu	37	chr1	1337499	1337499	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	actctggaaaaaatgccttcAggttccttcccatcccccaa	5	15	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:1337499A>G	uc001afo.3	-	4	510	c.414T>C	c.(412-414)CCT>CCC	p.P138P	CCNL2_uc001afh.2_5'Flank|CCNL2_uc001afj.2_5'Flank|CCNL2_uc001afk.2_5'Flank|CCNL2_uc001afi.2_5'Flank|LOC148413_uc001afn.1_RNA	NM_017971	NP_060441	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20 precursor	138							protein binding|rRNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		AAATGCCTTCAGGTTCCTTCC	0.463													0	0	0	0.007835	0	32	215										G	1337499	A	G	1337499	2	3	20	1	0	0	0	0	0	0	0	1	9786	175	7	5		5	MRPL20	1	1337499	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08		1337499	247913122	1	5705										
KIAA0562	9731	broad.mit.edu	37	chr1	3740058	3740058	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcctcactgcaacggtaacaCtttccaaacccgtctttttt	5	14	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:3740058C>A	uc001aky.2	-	19	2792	c.2433G>T	c.(2431-2433)AAG>AAT	p.K811N	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	811						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		AACGGTAACACTTTCCAAACC	0.507													1	0	0.000978159	0.010729	0.000997898	10	114										A	3740058	C	A	3740058	3	1	20	1	0	0	0	0	1	0	0	0	8184	564	20	4	360	4	KIAA0562	1	3740058	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2402559	3740058	245510563	2	5706										
CASZ1	54897	broad.mit.edu	37	chr1	10705093	10705093	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggtgatgttggtcacaaaaTagcagccggtgcggaggcag	16	7	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:10705093T>C	uc001aro.2	-	18	4069	c.3749A>G	c.(3748-3750)TAT>TGT	p.Y1250C		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGTCACAAAATAGCAGCCGGT	0.592													0	0	0	0.004289	0	27	205										C	10705093	T	C	10705093	3	2	20	1	0	0	0	0	1	0	0	0	2685	1406	49	5	1546	5	CASZ1	1	10705093	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	6965035	10705093	238545528	3	5707										
VPS13D	55187	broad.mit.edu	37	chr1	12405437	12405437	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttctgcctgacagacacacCcatgacctccggattcatca	7	15	3	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:12405437C>T	uc001atv.2	+	43	9033	c.8892C>T	c.(8890-8892)ACC>ACT	p.T2964T	VPS13D_uc001atw.2_Silent_p.T2939T|VPS13D_uc001atx.2_Silent_p.T2151T	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2963					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACAGACACACCCATGACCTCC	0.438													0	0	0	0.00333	0	23	166										T	12405437	C	T	12405437	2	4	20	1	0	0	0	0	0	0	0	1	17189	610	22	2		2	VPS13D	1	12405437	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1700344	12405437	236845184	4	5708										
PADI2	11240	broad.mit.edu	37	chr1	17395638	17395638	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgtggtaggcagaaatgtcGtcgatgaaggtgcattcgag	15	5	0	2	rs61731909		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:17395638G>A	uc001baf.2	-	16	1981	c.1899C>T	c.(1897-1899)GAC>GAT	p.D633D	PADI2_uc010ocm.1_Silent_p.D517D	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	633					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CAGAAATGTCGTCGATGAAGG	0.597													0	0	0	0.003954	0	19	173										A	17395638	G	A	17395638	2	1	20	1	0	0	0	0	0	0	0	1	11378	1136	40	2		2	PADI2	1	17395638	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4990201	17395638	231854983	5	5709										
PADI1	29943	broad.mit.edu	37	chr1	17552329	17552329	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acctggcgctggggccctgaGggctatggggctatcttgct	16	11	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:17552329G>C	uc001bah.1	+	5	524	c.432G>C	c.(430-432)GAG>GAC	p.E144D		NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	144					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GGGGCCCTGAGGGCTATGGGG	0.602													0	0	0	0.010504	0	18	150										C	17552329	G	C	17552329	3	2	20	1	0	0	0	0	1	0	0	0	11377	991	35	4	450	4	PADI1	1	17552329	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	156691	17552329	231698292	6	5710										
ZBTB40	9923	broad.mit.edu	37	chr1	22816495	22816495	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagcagctgtacactctgtgCaaggagcagcagttctgtga	12	10	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:22816495C>T	uc001bft.2	+	3	565	c.54C>T	c.(52-54)TGC>TGT	p.C18C	ZBTB40_uc001bfu.2_Silent_p.C18C|ZBTB40_uc009vqi.1_Silent_p.C18C	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	18					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		ACACTCTGTGCAAGGAGCAGC	0.547													0	0	0	0.004007	0	13	126										T	22816495	C	T	22816495	2	4	20	1	0	0	0	0	0	0	0	1	17539	718	25	2		2	ZBTB40	1	22816495	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5264166	22816495	226434126	7	5711										
EPHB2	2048	broad.mit.edu	37	chr1	23233202	23233202	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtcttggtgtttctctctcaGgggagtttggcgaggtctgc	15	8	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:23233202G>C	uc009vqj.1	+	11	2034	c.1889_splice	c.e11-1	p.G630_splice	EPHB2_uc001bge.2_Splice_Site_p.G631_splice|EPHB2_uc001bgf.2_Splice_Site_p.G630_splice|EPHB2_uc010odu.1_Splice_Site_p.G572_splice	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor						axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TTCTCTCTCAGGGGAGTTTGG	0.567									Hereditary_Prostate_Cancer				0	0	0	0.00308	0	7	48										C	23233202	G	C	23233202	5	2	20	1	0	0	0	0	0	0	1	0	5175	1014	35	4	1933	4	EPHB2	1	23233202	Splice_Site	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	416707	23233202	226017419	8	5712										
PAQR7	164091	broad.mit.edu	37	chr1	26189908	26189908	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acggccacccccacatagtcCaggaagaagaagctgtaatg	10	12	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:26189908C>T	uc001bkx.2	-	2	1090	c.423G>A	c.(421-423)CTG>CTA	p.L141L		NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	141	Helical; Name=3; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		CCACATAGTCCAGGAAGAAGA	0.547													0	0	0	0.010771	0	36	181										T	26189908	C	T	26189908	2	4	20	1	0	0	0	0	0	0	0	1	11440	581	21	2		2	PAQR7	1	26189908	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2956706	26189908	223060713	9	5713										
MACF1	23499	broad.mit.edu	37	chr1	39801743	39801743	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	actaaggaaaccaaacatcaAatttcctcatctaatgaatg	4	9	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:39801743A>G	uc010oiu.1	+	1	4934	c.4803A>G	c.(4801-4803)CAA>CAG	p.Q1601Q	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3166					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCAAACATCAAATTTCCTCAT	0.373													0	0	0	0.010504	0	20	102										G	39801743	A	G	39801743	2	3	20	1	0	0	0	0	0	0	0	1	9144	11	1	5		5	MACF1	1	39801743	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	13611835	39801743	209448878	10	5714										
ZMPSTE24	10269	broad.mit.edu	37	chr1	40737578	40737587	+	Frame_Shift_Del	DEL	ATCTATGCTG	ATCTATGCTG	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttttcaggttcttgtcacaAtctatgctgattatattgcc							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:40737578_40737587delATCTATGCTG	uc001cfg.2	+	6	851_860	c.640_649delATCTATGCTG	c.(640-651)ATCTATGCTGATfs	p.I214fs		NM_005857	NP_005848	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	214_217						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity				0	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TCTTGTCACAATCTATGCTGATTATATTGC	0.3																		11	173	---	---								-	40737587	ATCTATGCTG	-	40737578	7	5	20	1	0	1	0	1	0	0	0	0	17695	101	4	0	662	0	ZMPSTE24	1	40737578	Frame_Shift_Del	DEL	ATCTATGCTG	TCGA-BT-A3PK-01A-21D-A21Z-08	935835	40737578	208513043	11	5715										
PLK3	1263	broad.mit.edu	37	chr1	45266717	45266717	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cctcatcgcagatcctaaatGagattgagctgcaccgagac	9	12	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:45266717G>C	uc001cmn.2	+	3	428	c.328G>C	c.(328-330)GAG>CAG	p.E110Q	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	110	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					GATCCTAAATGAGATTGAGCT	0.587													0	0	0	0.001168	0	5	113										C	45266717	G	C	45266717	3	2	20	1	0	0	0	0	1	0	0	0	12097	1291	45	1	338	1	PLK3	1	45266717	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4529139	45266717	203983904	12	5716										
STIL	6491	broad.mit.edu	37	chr1	47746122	47746122	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggagaacaactgcccatatCtccctgaggtctcaaggcta	10	12	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:47746122C>G	uc001crc.1	-	12	2163	c.2008G>C	c.(2008-2010)GAT>CAT	p.D670H	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.D623H|STIL_uc010omo.1_Missense_Mutation_p.D670H|STIL_uc001crd.1_Missense_Mutation_p.D670H|STIL_uc001cre.1_Missense_Mutation_p.D670H|STIL_uc001crf.1_Missense_Mutation_p.D283H|STIL_uc001crg.1_Missense_Mutation_p.D623H	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	670	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				CTGCCCATATCTCCCTGAGGT	0.473													0	0	0	0.01441	0	50	135										G	47746122	C	G	47746122	3	3	20	1	0	0	0	0	1	0	0	0	15281	913	32	1	1882	1	STIL	1	47746122	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2479405	47746122	201504499	13	5717										
TMEM61	199964	broad.mit.edu	37	chr1	55457707	55457707	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttgctcttgatgccgtttcTgcggagacgacaccgagtgc	12	12	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:55457707T>C	uc001cyd.2	+	3	838	c.564T>C	c.(562-564)TCT>TCC	p.S188S		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	188						integral to membrane					0						ATGCCGTTTCTGCGGAGACGA	0.612													0	0	0	0.01441	0	93	209										C	55457707	T	C	55457707	2	2	20	1	0	0	0	0	0	0	0	1	16185	1567	55	5		5	TMEM61	1	55457707	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	7711585	55457707	193792914	14	5718										
LHX8	431707	broad.mit.edu	37	chr1	75622729	75622729	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctacgtgccccaagatggaaCgatgttaactgcgctgcata	10	11	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:75622729C>T	uc001dgo.2	+	9	1626	c.962C>T	c.(961-963)ACG>ATG	p.T321M	LHX8_uc001dgq.2_Missense_Mutation_p.T260M	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	321						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CAAGATGGAACGATGTTAACT	0.478													0	0	0	0.00278	0	18	84										T	75622729	C	T	75622729	3	4	20	1	0	0	0	0	1	0	0	0	8776	536	19	2	992	2	LHX8	1	75622729	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	20165022	75622729	173627892	15	5719										
NEXN	91624	broad.mit.edu	37	chr1	78383288	78383288	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	taaacctgtcccaaaaacctAtgtaccaaaacttggcaagg	6	11	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:78383288A>G	uc001dic.3	+	3	362	c.65A>G	c.(64-66)TAT>TGT	p.Y22C	NEXN_uc001dia.3_Missense_Mutation_p.Y22C|NEXN_uc009wcb.1_Intron|NEXN_uc001dib.3_Intron|NEXN_uc001did.1_5'Flank|NEXN_uc001dif.1_5'Flank	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	22					regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		CCAAAAACCTATGTACCAAAA	0.348													0	0	0	0.013537	0	10	51										G	78383288	A	G	78383288	3	3	20	1	0	0	0	0	1	0	0	0	10355	449	16	5	71	5	NEXN	1	78383288	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2760559	78383288	170867333	16	5720										
COL24A1	255631	broad.mit.edu	37	chr1	86304318	86304318	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctctccttggtcccccactgGaccctacagagaccacacac	6	19	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:86304318G>C	uc001dlj.2	-	43	3673	c.3631C>G	c.(3631-3633)CCA>GCA	p.P1211A	COL24A1_uc001dli.2_Missense_Mutation_p.P347A|COL24A1_uc010osd.1_Missense_Mutation_p.P511A|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1211	Collagen-like 13.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCCCCACTGGACCCTACAGA	0.408													0	0	0	0.003271	0	25	133										C	86304318	G	C	86304318	3	2	20	1	0	0	0	0	1	0	0	0	3683	1174	41	1	1585	1	COL24A1	1	86304318	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	7921030	86304318	162946303	17	5721										
GBP1	2633	broad.mit.edu	37	chr1	89525999	89525999	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agactgcaccgtggagcccaGagagaagcctgcaagggaga	15	10	0	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:89525999G>T	uc001dmx.2	-	3	419	c.199C>A	c.(199-201)CTG>ATG	p.L67M		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	67					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GTGGAGCCCAGAGAGAAGCCT	0.517													1	0	1.99824e-07	0.00499	2.12429e-07	14	112										T	89525999	G	T	89525999	3	4	20	1	0	0	0	0	1	0	0	0	6273	933	33	3	1615	3	GBP1	1	89525999	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3221681	89525999	159724622	18	5722										
LRIG2	9860	broad.mit.edu	37	chr1	113655277	113655277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acgtcatgcccgaggatgacGtcttctttattgccaatgtg	10	10	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:113655277G>A	uc001edf.1	+	14	2173	c.1975G>A	c.(1975-1977)GTC>ATC	p.V659I	LRIG2_uc009wgn.1_Missense_Mutation_p.V556I	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	659	Ig-like C2-type 2.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CGAGGATGACGTCTTCTTTAT	0.483													0	0	0	0.006214	0	10	56										A	113655277	G	A	113655277	3	1	20	1	0	0	0	0	1	0	0	0	8945	1145	40	2	2029	2	LRIG2	1	113655277	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	24129278	113655277	135595344	19	5723										
FMO5	2330	broad.mit.edu	37	chr1	146658516	146658516	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttatagcaaagaaggcaagaGctagcataaacttgcctatt	8	7	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:146658516G>A	uc001epi.2	-	9	1954	c.1565C>T	c.(1564-1566)GCT>GTT	p.A522V	FMO5_uc001eph.3_Intron|FMO5_uc001epj.2_3'UTR	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	522						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					GAAGGCAAGAGCTAGCATAAA	0.403													0	0	0	0.008291	0	9	76										A	146658516	G	A	146658516	3	1	20	1	0	0	0	0	1	0	0	0	5958	971	34	2	183	2	FMO5	1	146658516	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	33003239	146658516	102592105	20	5724										
TCHHL1	126637	broad.mit.edu	37	chr1	152059640	152059640	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttaggatcattgtgttcaGatgcttctcctggaaagttg	10	7	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:152059640G>C	uc001ezo.1	-	3	583	c.518C>G	c.(517-519)TCT>TGT	p.S173C		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	173							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATTGTGTTCAGATGCTTCTCC	0.438													0	0	0	0.008291	0	9	127										C	152059640	G	C	152059640	3	2	20	1	0	0	0	0	1	0	0	0	15698	942	33	1	2200	1	TCHHL1	1	152059640	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	5401124	152059640	97190981	21	5725										
TCHHL1	126637	broad.mit.edu	37	chr1	152060608	152060608	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acacagaggacatttctcagGagctgaggcatctttacaaa	9	9	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:152060608G>C	uc001ezo.1	-	2	77	c.12C>G	c.(10-12)CTC>CTG	p.L4L		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	4							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CATTTCTCAGGAGCTGAGGCA	0.458													0	0	0	0.004482	0	7	105										C	152060608	G	C	152060608	2	2	20	1	0	0	0	0	0	0	0	1	15698	1161	41	1		1	TCHHL1	1	152060608	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	968	152060608	97190013	22	5726										
RPTN	126638	broad.mit.edu	37	chr1	152127881	152127884	+	Frame_Shift_Del	DEL	TGTC	TGTC	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cataatgatagctctggcctTgtctgtctgtctgaccgtag							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:152127881_152127884delTGTC	uc001ezs.1	-	3	1756_1759	c.1691_1694delGACA	c.(1690-1695)AGACAAfs	p.R564fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	564_565	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						GCTCTGGCCTTGTCTGTCTGTCTG	0.485																		7	1314	---	---								-	152127884	TGTC	-	152127881	7	5	20	1	0	1	0	1	0	0	0	0	13664	1812	63	0	664	0	RPTN	1	152127881	Frame_Shift_Del	DEL	TGTC	TCGA-BT-A3PK-01A-21D-A21Z-08	67273	152127881	97122740	23	5727										
HRNR	388697	broad.mit.edu	37	chr1	152185716	152185716	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acttccatgctgactataacCagaggactgtcctgagccag	9	12	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:152185716C>G	uc001ezt.1	-	3	8465	c.8389G>C	c.(8389-8391)GGT>CGT	p.G2797R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2797	30.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTATAACCAGAGGACTGT	0.537													0	0	0	0.00333	0	21	166										G	152185716	C	G	152185716	3	3	20	1	0	0	0	0	1	0	0	0	7359	594	21	4	167	4	HRNR	1	152185716	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	57835	152185716	97064905	24	5728										
TPM3	7170	broad.mit.edu	37	chr1	154141837	154141837	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcgctaatggccttgtacttCagtttctgggcatagagctc	10	10	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:154141837C>T	uc001fec.1	-	9	913	c.798G>A	c.(796-798)CTG>CTA	p.L266L	TPM3_uc001fdx.1_Intron|TPM3_uc010pei.1_Intron|TPM3_uc001fdy.1_Intron|TPM3_uc001fdz.1_Intron|TPM3_uc001fea.1_Intron|TPM3_uc001feb.1_Intron|TPM3_uc010pej.1_Intron|TPM3_uc009wor.2_Intron|TPM3_uc001fed.1_Silent_p.L229L	NM_152263	NP_689476	P06753	TPM3_HUMAN	tropomyosin 3 isoform 1	265	By similarity.				cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/ALK(33)	haematopoietic_and_lymphoid_tissue(22)|soft_tissue(11)|skin(1)	34	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CCTTGTACTTCAGTTTCTGGG	0.517			T	NTRK1|ALK	papillary thyroid|ALCL								0	0	0	0.008291	0	8	131										T	154141837	C	T	154141837	2	4	20	1	0	0	0	0	0	0	0	1	16404	813	29	1		1	TPM3	1	154141837	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1956121	154141837	95108784	25	5729										
SMG5	23381	broad.mit.edu	37	chr1	156230278	156230278	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agcaggggccgatccgtgtcAaagttaaagcgtctgtgggc	15	9	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:156230278A>G	uc001foc.3	-	15	2396	c.2247T>C	c.(2245-2247)TTT>TTC	p.F749F	SMG5_uc009wrv.2_Silent_p.F234F	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	749					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GATCCGTGTCAAAGTTAAAGC	0.547													0	0	0	0.010818	0	24	179										G	156230278	A	G	156230278	2	3	20	1	0	0	0	0	0	0	0	1	14796	127	5	5		5	SMG5	1	156230278	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2088441	156230278	93020343	26	5730										
POGK	57645	broad.mit.edu	37	chr1	166818806	166818806	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaagtgcccgtgccccagcaCctgccggaagacctgactga	11	15	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:166818806C>G	uc001gdt.1	+	5	1110	c.990C>G	c.(988-990)CAC>CAG	p.H330Q	POGK_uc010ple.1_Missense_Mutation_p.H245Q|POGK_uc010plf.1_Missense_Mutation_p.H212Q	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	330					multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TGCCCCAGCACCTGCCGGAAG	0.547													0	0	0	0.007835	0	35	118										G	166818806	C	G	166818806	3	3	20	1	0	0	0	0	1	0	0	0	12185	506	18	4	1004	4	POGK	1	166818806	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	10588528	166818806	82431815	27	5731										
FMO4	2329	broad.mit.edu	37	chr1	171310693	171310693	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcttgggaagttttctttggAccatgtactccttatcagta	9	8	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:171310693A>G	uc001gho.2	+	10	1609	c.1392A>G	c.(1390-1392)GGA>GGG	p.G464G		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	464					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TTTTCTTTGGACCATGTACTC	0.498													0	0	0	0.00499	0	14	113										G	171310693	A	G	171310693	2	3	20	1	0	0	0	0	0	0	0	1	5957	262	10	5		5	FMO4	1	171310693	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	4491887	171310693	77939928	28	5732										
DNM3	26052	broad.mit.edu	37	chr1	172017833	172017833	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgaaagggccttccttgaaGagtgtggatctggtaataca	12	6	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:172017833G>C	uc001gie.2	+	10	1454	c.1278G>C	c.(1276-1278)AAG>AAC	p.K426N	DNM3_uc001gid.3_Missense_Mutation_p.K426N|DNM3_uc009wwb.2_Missense_Mutation_p.K426N|DNM3_uc001gif.2_Missense_Mutation_p.K426N	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	426					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CTTCCTTGAAGAGTGTGGATC	0.383													0	0	0	0.00308	0	7	150										C	172017833	G	C	172017833	3	2	20	1	0	0	0	0	1	0	0	0	4673	933	33	1	1316	1	DNM3	1	172017833	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	707140	172017833	77232788	29	5733										
SOAT1	6646	broad.mit.edu	37	chr1	179320559	179320559	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttactctgcttttattctCaagaatggtatgcacgtcag	7	9	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:179320559C>G	uc001gml.2	+	15	1621	c.1558C>G	c.(1558-1560)CAA>GAA	p.Q520E	SOAT1_uc010pni.1_Missense_Mutation_p.Q455E|SOAT1_uc001gmm.2_Missense_Mutation_p.Q462E|SOAT1_uc010pnj.1_Missense_Mutation_p.Q256E|SOAT1_uc010pnk.1_Missense_Mutation_p.Q455E	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	520					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	CTTTTATTCTCAAGAATGGTA	0.418													0	0	0	0.013537	0	10	249										G	179320559	C	G	179320559	3	3	20	1	0	0	0	0	1	0	0	0	14910	827	29	1	1612	1	SOAT1	1	179320559	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	7302726	179320559	69930062	30	5734										
CACNA1E	777	broad.mit.edu	37	chr1	181759626	181759626	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgagtccactctctccccaGgatatattccagttggcttg	8	12	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:181759626G>T	uc001gow.2	+	44	5997	c.5832G>T	c.(5830-5832)CAG>CAT	p.Q1944H	CACNA1E_uc009wxs.2_Missense_Mutation_p.Q1832H|CACNA1E_uc009wxt.2_Missense_Mutation_p.Q1170H	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1944	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCTCTCCCCAGGATATATTCC	0.493													1	0	2.18419e-29	0.01441	2.50962e-29	52	106										T	181759626	G	T	181759626	3	4	20	1	0	0	0	0	1	0	0	0	2542	991	35	4	6006	4	CACNA1E	1	181759626	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2439067	181759626	67490995	31	5735										
CFH	3075	broad.mit.edu	37	chr1	196659330	196659330	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agaccacagttacatgtatgGagaatggctggtctcctact	10	9	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:196659330G>A	uc001gtj.3	+	9	1537	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	CFH_uc001gti.3_Missense_Mutation_p.E433K|CFH_uc009wyw.2_Missense_Mutation_p.E408K|CFH_uc009wyx.2_Missense_Mutation_p.E369K	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	433	Sushi 7.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TACATGTATGGAGAATGGCTG	0.433													0	0	0	0.001984	0	5	112										A	196659330	G	A	196659330	3	1	20	1	0	0	0	0	1	0	0	0	3283	1175	41	1	1331	1	CFH	1	196659330	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	14899704	196659330	52591291	32	5736										
DDX59	83479	broad.mit.edu	37	chr1	200617674	200617674	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcctgtgctcactacaacttCatagtctccttcaagtaatc	4	13	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:200617674C>T	uc009wzk.2	-	7	1732	c.1489G>A	c.(1489-1491)GAA>AAA	p.E497K	DDX59_uc010ppl.1_Missense_Mutation_p.E497K	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	497	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ACTACAACTTCATAGTCTCCT	0.363													0	0	0	0.010729	0	10	235										T	200617674	C	T	200617674	3	4	20	1	0	0	0	0	1	0	0	0	4376	835	29	1	378	1	DDX59	1	200617674	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3958344	200617674	48632947	33	5737										
KIF21B	23046	broad.mit.edu	37	chr1	200967639	200967639	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggctgttctccagctcgtcGatcagcttctgcttgatttc	9	12	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:200967639G>C	uc001gvs.1	-	14	2267	c.1950C>G	c.(1948-1950)ATC>ATG	p.I650M	KIF21B_uc001gvr.1_Missense_Mutation_p.I650M|KIF21B_uc009wzl.1_Missense_Mutation_p.I650M|KIF21B_uc010ppn.1_Missense_Mutation_p.I650M	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	650	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CCAGCTCGTCGATCAGCTTCT	0.562													0	0	0	0.004656	0	23	235										C	200967639	G	C	200967639	3	2	20	1	0	0	0	0	1	0	0	0	8289	1048	37	1	3008	1	KIF21B	1	200967639	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	349965	200967639	48282982	34	5738										
KDM5B	10765	broad.mit.edu	37	chr1	202743773	202743773	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaataagtccaagatcttccTctccacatgtggaattttca	5	10	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:202743773T>C	uc001gyf.2	-	3	489	c.373A>G	c.(373-375)AGG>GGG	p.R125G	KDM5B_uc009xag.2_Missense_Mutation_p.R125G|KDM5B_uc001gyg.1_5'UTR	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	125	ARID.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						AAGATCTTCCTCTCCACATGT	0.358													0	0	0	0.012319	0	17	68										C	202743773	T	C	202743773	3	2	20	1	0	0	0	0	1	0	0	0	8134	1550	54	5	4361	5	KDM5B	1	202743773	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	1776134	202743773	46506848	35	5739										
C4BPA	722	broad.mit.edu	37	chr1	207300065	207300065	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catgattctttagaaatcacCtgtcgcaagccagatgtttc	7	10	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:207300065C>T	uc001hfo.2	+	7	908	c.714C>T	c.(712-714)ACC>ACT	p.T238T		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	238	Sushi 4.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TAGAAATCACCTGTCGCAAGC	0.373													0	0	0	0.004656	0	21	100										T	207300065	C	T	207300065	2	4	20	1	0	0	0	0	0	0	0	1	2249	668	24	2		2	C4BPA	1	207300065	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	4556292	207300065	41950556	36	5740										
WDR26	80232	broad.mit.edu	37	chr1	224588738	224588738	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acttgtcaaactgtcttcatGagactggctcatttttgtcc	7	10	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:224588738G>A	uc001hop.3	-	9	1258	c.892C>T	c.(892-894)CAT>TAT	p.H298Y	WDR26_uc001hoq.3_Missense_Mutation_p.H282Y|WDR26_uc010pvh.1_Missense_Mutation_p.H5Y	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	445	WD 3.					cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		CTGTCTTCATGAGACTGGCTC	0.418													0	0	0	0.008291	0	9	55										A	224588738	G	A	224588738	3	1	20	1	0	0	0	0	1	0	0	0	17280	1290	45	1	676	1	WDR26	1	224588738	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	17288673	224588738	24661883	37	5741										
TMEM63A	9725	broad.mit.edu	37	chr1	226053628	226053628	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctccacagtctccttcctggCatctctggggagtcctgtga	10	14	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:226053628C>T	uc001hpm.1	-	10	965	c.715G>A	c.(715-717)GCC>ACC	p.A239T		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	239						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					TCCTTCCTGGCATCTCTGGGG	0.627													0	0	0	0.010504	0	14	36										T	226053628	C	T	226053628	3	4	20	1	0	0	0	0	1	0	0	0	16187	710	25	2	1768	2	TMEM63A	1	226053628	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1464890	226053628	23196993	38	5742										
OR13G1	441933	broad.mit.edu	37	chr1	247835472	247835472	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcctgcctgcatctccctaTtctggaagctgtacaccatc	6	15	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:247835472T>A	uc001idi.1	-	1	872	c.872A>T	c.(871-873)AAT>ATT	p.N291I		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	291	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATCTCCCTATTCTGGAAGCT	0.448													0	0	0	0.00308	0	6	152										A	247835472	T	A	247835472	3	1	20	1	0	0	0	0	1	0	0	0	10942	1493	52	5	55	5	OR13G1	1	247835472	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	21781844	247835472	1415149	39	5743										
TRIM58	25893	broad.mit.edu	37	chr1	248039733	248039733	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aacaatagcagggtcaggaaAttgggcatccagggatcatt	12	7	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:248039733A>G	uc001ido.2	+	6	1451	c.1403A>G	c.(1402-1404)AAT>AGT	p.N468S	OR2W3_uc001idp.1_Intron	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	468						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGGTCAGGAAATTGGGCATCC	0.448													0	0	0	0.009535	0	26	81										G	248039733	A	G	248039733	3	3	20	1	0	0	0	0	1	0	0	0	16528	101	4	5	1425	5	TRIM58	1	248039733	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	204261	248039733	1210888	40	5744										
OR2T1	26696	broad.mit.edu	37	chr1	248570047	248570047	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctacgagacagtgatgtatgTgtgctgtgttttgatgctgc	13	6	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr1:248570047T>C	uc010pzm.1	+	1	752	c.752T>C	c.(751-753)GTG>GCG	p.V251A		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	251	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGATGTATGTGTGCTGTGTT	0.507													0	0	0	0.007291	0	26	89										C	248570047	T	C	248570047	3	2	20	1	0	0	0	0	1	0	0	0	11016	1696	59	5	754	5	OR2T1	1	248570047	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	530314	248570047	680574	41	5745										
DNAJC27	51277	broad.mit.edu	37	chr2	25180826	25180826	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atcacaccctgtgtgtccttGtaaaactcatttcgaacctt	5	12	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:25180826G>A	uc002rft.1	-	4	309	c.258C>T	c.(256-258)TAC>TAT	p.Y86Y	DNAJC27_uc010ykn.1_Silent_p.Y15Y|DNAJC27_uc002rfu.1_RNA|DNAJC27_uc010eyg.1_Silent_p.Y86Y	NM_016544	NP_057628	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	86					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			skin(1)	1						GTGTGTCCTTGTAAAACTCAT	0.418													0	0	0	0.001168	0	6	56										A	25180826	G	A	25180826	2	1	20	1	0	0	0	0	0	0	0	1	4645	1372	48	2		2	DNAJC27	2	25180826	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08		25180826	218018547	42	5746										
C2orf16	84226	broad.mit.edu	37	chr2	27803662	27803662	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	accaagcagtatcaaaagagAcaagaggtcagctgacaagc	10	9	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:27803662A>G	uc002rkz.3	+	1	4274	c.4223A>G	c.(4222-4224)GAC>GGC	p.D1408G	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1408										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATCAAAAGAGACAAGAGGTCA	0.488													0	0	0	0.005443	0	28	111										G	27803662	A	G	27803662	3	3	20	1	0	0	0	0	1	0	0	0	2157	275	10	5	4225	5	C2orf16	2	27803662	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2622836	27803662	215395711	43	5747										
PLB1	151056	broad.mit.edu	37	chr2	28828806	28828806	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagctggccagagccctttgGaccaatatggtaaaataagt	10	9	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:28828806G>T	uc002rmb.1	+	42	3048	c.3048G>T	c.(3046-3048)TGG>TGT	p.W1016C	PLB1_uc010ezj.1_Missense_Mutation_p.W1005C|PLB1_uc002rme.1_Intron|PLB1_uc002rmf.1_RNA	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	1016	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|3.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GAGCCCTTTGGACCAATATGG	0.522													1	0	6.12954e-19	0.004656	6.92044e-19	24	185										T	28828806	G	T	28828806	3	4	20	1	0	0	0	0	1	0	0	0	12024	1183	41	3	3247	3	PLB1	2	28828806	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1025144	28828806	214370567	44	5748										
GPR75	10936	broad.mit.edu	37	chr2	54080838	54080838	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aattcaaactggtaaagaatGaagctcccattgctggagag	10	7	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:54080838G>C	uc002rxo.3	-	2	1327	c.1056C>G	c.(1054-1056)TTC>TTG	p.F352L	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	352	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GGTAAAGAATGAAGCTCCCAT	0.443													0	0	0	0.010504	0	20	91										C	54080838	G	C	54080838	3	2	20	1	0	0	0	0	1	0	0	0	6708	1281	45	1	570	1	GPR75	2	54080838	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	25252032	54080838	189118535	45	5749										
ADD2	119	broad.mit.edu	37	chr2	70890760	70890760	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caggcctttgctgaggatttCctctgccgtctgctcctcct	9	15	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:70890760C>T	uc002sgz.2	-	16	2443	c.1978G>A	c.(1978-1980)GAA>AAA	p.E660K	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.E354K|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	660					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						CTGAGGATTTCCTCTGCCGTC	0.577													0	0	0	0.004289	0	33	141										T	70890760	C	T	70890760	3	4	20	1	0	0	0	0	1	0	0	0	305	864	30	1	206	1	ADD2	2	70890760	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	16809922	70890760	172308613	46	5750										
ALMS1	7840	broad.mit.edu	37	chr2	73651764	73651764	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agggaataatgaagagactaTttcgtctgttgatgaactga	11	4	1	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:73651764T>A	uc002sje.1	+	6	1085	c.974T>A	c.(973-975)ATT>AAT	p.I325N	ALMS1_uc002sjf.1_Missense_Mutation_p.I282N	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	324					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GAAGAGACTATTTCGTCTGTT	0.418													0	0	0	0.004482	0	9	43										A	73651764	T	A	73651764	3	1	20	1	0	0	0	0	1	0	0	0	535	1493	52	5	989	5	ALMS1	2	73651764	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	2761004	73651764	169547609	47	5751										
HTRA2	27429	broad.mit.edu	37	chr2	74757342	74757342	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggggtcactgaaccccgagCatgcctgacgtctgggaccc	13	14	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:74757342C>T	uc002smi.1	+	1	811	c.209C>T	c.(208-210)GCA>GTA	p.A70V	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.A70V|HTRA2_uc002smk.1_Missense_Mutation_p.A70V|HTRA2_uc002sml.1_Missense_Mutation_p.A70V|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	70					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						GAACCCCGAGCATGCCTGACG	0.657													0	0	0	0.009096	0	4	14										T	74757342	C	T	74757342	3	4	20	1	0	0	0	0	1	0	0	0	7454	710	25	2	211	2	HTRA2	2	74757342	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1105578	74757342	168442031	48	5752										
LRRTM4	80059	broad.mit.edu	37	chr2	77746503	77746503	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtctttagtgagttagatctCaagtgcaaaatgatgagttt	10	4	2	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:77746503C>G	uc002snr.2	-	3	907	c.492G>C	c.(490-492)TTG>TTC	p.L164F	LRRTM4_uc002snq.2_Missense_Mutation_p.L164F|LRRTM4_uc002sns.2_Missense_Mutation_p.L164F|LRRTM4_uc002snt.2_Missense_Mutation_p.L165F	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	164	LRR 5.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		AGTTAGATCTCAAGTGCAAAA	0.413													0	0	0	0.006214	0	8	80										G	77746503	C	G	77746503	3	3	20	1	0	0	0	0	1	0	0	0	9042	825	29	1	1294	1	LRRTM4	2	77746503	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2989161	77746503	165452870	49	5753										
ZNF2	7549	broad.mit.edu	37	chr2	95847683	95847683	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cacactggagacaagccataTgaatgcagcgaatgcgggaa	12	9	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:95847683T>C	uc002suf.2	+	6	1569	c.1107T>C	c.(1105-1107)TAT>TAC	p.Y369Y	ZNF2_uc002sug.2_Silent_p.Y327Y|ZNF2_uc010yue.1_Silent_p.Y332Y|ZNF2_uc010fhs.2_Silent_p.Y290Y	NM_021088	NP_066574	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2 isoform a	369	C2H2-type 8.			Y -> H (in Ref. 2; AAH05068).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		ACAAGCCATATGAATGCAGCG	0.552													0	0	0	0.011902	0	31	169										C	95847683	T	C	95847683	2	2	20	1	0	0	0	0	0	0	0	1	17757	1471	51	5		5	ZNF2	2	95847683	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	18101180	95847683	147351690	50	5754										
CNNM4	26504	broad.mit.edu	37	chr2	97427544	97427544	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acctcatcgggtccggcctcAtggcggtggcctcctccacc	11	18	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:97427544A>T	uc002swx.2	+	1	906	c.808A>T	c.(808-810)ATG>TTG	p.M270L		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	270	Helical; (Potential).|DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						GTCCGGCCTCATGGCGGTGGC	0.592													0	0	0	0.00245	0	12	176										T	97427544	A	T	97427544	3	4	20	1	0	0	0	0	1	0	0	0	3615	217	8	5	810	5	CNNM4	2	97427544	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	1579861	97427544	145771829	51	5755										
AFF3	3899	broad.mit.edu	37	chr2	100170804	100170804	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttggccaggttgtcggccatCtcccagtagtcgtagctgtg	13	11	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:100170804C>G	uc002tag.2	-	23	3764	c.3528G>C	c.(3526-3528)GAG>GAC	p.E1176D	AFF3_uc002taf.2_Missense_Mutation_p.E1201D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1176					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TGTCGGCCATCTCCCAGTAGT	0.507													0	0	0	0.008291	0	10	190										G	100170804	C	G	100170804	3	3	20	1	0	0	0	0	1	0	0	0	358	912	32	1	160	1	AFF3	2	100170804	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2743260	100170804	143028569	52	5756										
IL1B	3553	broad.mit.edu	37	chr2	113590327	113590327	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttttttgctgtgagtcccgGagcgtgcagttcagtgatcg	13	9	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:113590327G>C	uc002tii.1	-	5	465	c.378C>G	c.(376-378)CTC>CTG	p.L126L	IL1B_uc002tih.1_Silent_p.L95L	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	126					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	GTGAGTCCCGGAGCGTGCAGT	0.478													0	0	0	0.008871	0	14	157										C	113590327	G	C	113590327	2	2	20	1	0	0	0	0	0	0	0	1	7651	1161	41	1		1	IL1B	2	113590327	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	13419523	113590327	129609046	53	5757										
NCKAP5	344148	broad.mit.edu	37	chr2	133887605	133887606	+	Missense_Mutation	DNP	GG	GG	TT													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tctgttgcgttcagactctaGggtcacctcctgcaaccgct							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:133887605_133887606GG>TT	uc002ttp.2	-	6	659_660	c.285_286CC>AA	c.(283-288)ACCCTA>ACAATA	p.L96I	NCKAP5_uc002ttq.2_Missense_Mutation_p.L96I|NCKAP5_uc002ttt.1_Missense_Mutation_p.L96I|NCKAP5_uc002tts.1_Missense_Mutation_p.L71I	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	96	Potential.						protein binding				0						TCAGACTCTAGGGTCACCTCCT	0.48													0	0	0	0.004672	0	5	28										TT	133887606	GG	TT	133887605	3	4	20	1	0	0	0	0	1	0	0	0	10223	991	35	4	5503	4	NCKAP5	2	133887605	Missense_Mutation	DNP	GG	TCGA-BT-A3PK-01A-21D-A21Z-08	20297278	133887605	109311768	54	5758										
NEB	4703	broad.mit.edu	37	chr2	152536298	152536298	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atcgcatcagttctcaggtcAtatcccttcttgctcaagtc	6	13	5	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:152536298A>G	uc010fnx.2	-	32	3383	c.3192T>C	c.(3190-3192)TAT>TAC	p.Y1064Y		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1064	Nebulin 26.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTCAGGTCATATCCCTTCT	0.443													0	0	0	0.001855	0	10	117										G	152536298	A	G	152536298	2	3	20	1	0	0	0	0	0	0	0	1	10302	224	8	5		5	NEB	2	152536298	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	18648693	152536298	90663075	55	5759										
TBR1	10716	broad.mit.edu	37	chr2	162273127	162273127	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtcagatacagacaattttcCtgactccaaggactcaccag	7	12	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:162273127C>T	uc002ubw.1	+	1	508	c.206C>T	c.(205-207)CCT>CTT	p.P69L	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	69						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GACAATTTTCCTGACTCCAAG	0.488													0	0	0	0.013537	0	11	72										T	162273127	C	T	162273127	3	4	20	1	0	0	0	0	1	0	0	0	15644	681	24	2	208	2	TBR1	2	162273127	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	9736829	162273127	80926246	56	5760										
DHRS9	10170	broad.mit.edu	37	chr2	169948457	169948457	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aatatggagaaggttacattGaaaaaagtgagtttccgggc	12	4	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:169948457G>A	uc002uep.2	+	7	2234	c.730G>A	c.(730-732)GAA>AAA	p.E244K	DHRS9_uc002ueq.2_Missense_Mutation_p.E244K|DHRS9_uc010zdc.1_Missense_Mutation_p.E304K|DHRS9_uc010zdd.1_Missense_Mutation_p.E244K|DHRS9_uc010zde.1_Missense_Mutation_p.E244K	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	244					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						AGGTTACATTGAAAAAAGTGA	0.403													0	0	0	0.009096	0	4	43										A	169948457	G	A	169948457	3	1	20	1	0	0	0	0	1	0	0	0	4498	1291	45	1	740	1	DHRS9	2	169948457	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	7675330	169948457	73250916	57	5761										
MTX2	10651	broad.mit.edu	37	chr2	177161616	177161616	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccttggcctgaaaatgctacAttatatcagcaattgaaagg	8	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:177161616A>G	uc002ukx.2	+	2	304	c.69A>G	c.(67-69)ACA>ACG	p.T23T	MTX2_uc002ukw.2_Silent_p.T13T	NM_006554	NP_006545	O75431	MTX2_HUMAN	metaxin 2	23					protein targeting to mitochondrion	mitochondrial outer membrane				ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00365)|Epithelial(96;0.0654)|all cancers(119;0.181)			AAAATGCTACATTATATCAGC	0.313													0	0	0	0.003954	0	21	150										G	177161616	A	G	177161616	2	3	20	1	0	0	0	0	0	0	0	1	9968	204	8	5		5	MTX2	2	177161616	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	7213159	177161616	66037757	58	5762										
TTN	7273	broad.mit.edu	37	chr2	179635334	179635334	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gacattagggtgtgtaagctCgacagtgaaaacagcatcct	11	8	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:179635334C>G	uc010zfg.1	-	35	8409	c.8185G>C	c.(8185-8187)GAG>CAG	p.E2729Q	TTN_uc010zfh.1_Missense_Mutation_p.E2683Q|TTN_uc010zfi.1_Missense_Mutation_p.E2683Q|TTN_uc010zfj.1_Missense_Mutation_p.E2683Q|TTN_uc002unb.2_Missense_Mutation_p.E2729Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2729							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGTAAGCTCGACAGTGAAA	0.378													0	0	0	0.007413	0	16	136										G	179635334	C	G	179635334	3	3	20	1	0	0	0	0	1	0	0	0	16732	893	31	1	103115	1	TTN	2	179635334	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2473718	179635334	63564039	59	5763										
SLC39A10	57181	broad.mit.edu	37	chr2	196581361	196581361	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atcctttgctataaatacagGaactgatgactcggttgttt	8	7	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:196581361G>C	uc002utg.3	+	7	1911	c.1697G>C	c.(1696-1698)GGA>GCA	p.G566A	SLC39A10_uc002uth.3_Missense_Mutation_p.G566A|SLC39A10_uc010zgp.1_Missense_Mutation_p.G116A	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	566					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			ATAAATACAGGAACTGATGAC	0.323													0	0	0	0.013537	0	11	82										C	196581361	G	C	196581361	3	2	20	1	0	0	0	0	1	0	0	0	14613	1188	41	1	1719	1	SLC39A10	2	196581361	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	16946027	196581361	46618012	60	5764										
FN1	2335	broad.mit.edu	37	chr2	216245603	216245603	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggcaaccacactgactgtgtActcagaacccggtctgaggc	11	13	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:216245603A>G	uc002vfa.2	-	33	5631	c.5365T>C	c.(5365-5367)TAC>CAC	p.Y1789H	FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Missense_Mutation_p.Y1789H|FN1_uc002vfe.2_Missense_Mutation_p.Y1698H|FN1_uc002vff.2_Missense_Mutation_p.Y1698H|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Missense_Mutation_p.Y1789H|FN1_uc002vfj.2_Intron|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Intron|FN1_uc002vfk.1_5'Flank|FN1_uc010fva.1_5'Flank|FN1_uc010fvb.1_5'Flank|FN1_uc010fvc.1_Missense_Mutation_p.Y151H|FN1_uc010fvd.1_Intron	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1788	Heparin-binding 2.|Fibronectin type-III 13.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGACTGTGTACTCAGAACCC	0.542													0	0	0	0.010504	0	22	127										G	216245603	A	G	216245603	3	3	20	1	0	0	0	0	1	0	0	0	5962	391	14	5	2124	5	FN1	2	216245603	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	19664242	216245603	26953770	61	5765										
ARPC2	10109	broad.mit.edu	37	chr2	219110212	219110212	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttagccacagggaacctcctCtggagctgaaagacacagac	10	12	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:219110212C>G	uc002vhd.2	+	8	731	c.619C>G	c.(619-621)CTG>GTG	p.L207V	ARPC2_uc002vhe.2_Missense_Mutation_p.L207V|ARPC2_uc002vhf.2_Missense_Mutation_p.L93V	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	207					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		GGAACCTCCTCTGGAGCTGAA	0.527													0	0	0	0.010729	0	11	99										G	219110212	C	G	219110212	3	3	20	1	0	0	0	0	1	0	0	0	971	912	32	1	645	1	ARPC2	2	219110212	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2864609	219110212	24089161	62	5766										
WNT10A	80326	broad.mit.edu	37	chr2	219746934	219746934	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctccccccggagcccgtgctCaatgccaacacagtgtgcct	9	18	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:219746934C>T	uc002vjd.1	+	2	628	c.165C>T	c.(163-165)CTC>CTT	p.L55L		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	55					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCCCGTGCTCAATGCCAACA	0.617													0	0	0	0.00278	0	19	67										T	219746934	C	T	219746934	2	4	20	1	0	0	0	0	0	0	0	1	17379	813	29	1		1	WNT10A	2	219746934	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	636722	219746934	23452439	63	5767										
COL4A3	1285	broad.mit.edu	37	chr2	228172496	228172496	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agtggatcacctgcaacctgGacaacgagaggctttgtctt	11	10	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:228172496G>A	uc002vom.1	+	48	4485	c.4323G>A	c.(4321-4323)TGG>TGA	p.W1441*	COL4A3_uc002von.1_Nonsense_Mutation_p.W1441*|COL4A3_uc002voo.1_Nonsense_Mutation_p.W1441*|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'UTR	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1441	Epitope recognized by Goodpasture antibodies.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CTGCAACCTGGACAACGAGAG	0.468													0	0	0	0.00245	0	13	88										A	228172496	G	A	228172496	4	1	20	1	0	0	0	0	0	1	0	0	3691	1183	41	1	4513	1	COL4A3	2	228172496	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	8425562	228172496	15026877	64	5768										
ALPI	248	broad.mit.edu	37	chr2	233321093	233321093	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccggccttctggaaccgccaGgcagctgaggccctggatgc	14	15	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:233321093G>A	uc002vst.3	+	2	179	c.102G>A	c.(100-102)CAG>CAA	p.Q34Q	ALPI_uc002vsu.3_5'UTR	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	34					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGAACCGCCAGGCAGCTGAGG	0.627													0	0	0	0.007413	0	17	79										A	233321093	G	A	233321093	2	1	20	1	0	0	0	0	0	0	0	1	543	991	35	2		2	ALPI	2	233321093	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	5148597	233321093	9878280	65	5769										
MTERFD2	130916	broad.mit.edu	37	chr2	242035577	242035577	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtcatcagatgtgctgctctCagactcctcctcctcccgag	8	16	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:242035577C>G	uc002wan.1	-	3	1562	c.1069G>C	c.(1069-1071)GAG>CAG	p.E357Q	MTERFD2_uc010zoj.1_Missense_Mutation_p.E140Q	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	328										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		GTGCTGCTCTCAGACTCCTCC	0.333													0	0	0	0.008291	0	6	55										G	242035577	C	G	242035577	3	3	20	1	0	0	0	0	1	0	0	0	9920	835	29	1	167	1	MTERFD2	2	242035577	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	8714484	242035577	1163796	66	5770										
ING5	84289	broad.mit.edu	37	chr2	242662468	242662468	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caggtctcctatggggagatGattggctgtgacaatccaga	13	8	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr2:242662468G>A	uc002wcd.2	+	6	622	c.597G>A	c.(595-597)ATG>ATA	p.M199I		NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	199	PHD-type.				DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		ATGGGGAGATGATTGGCTGTG	0.602													0	0	0	0.000602	0	5	82										A	242662468	G	A	242662468	3	1	20	1	0	0	0	0	1	0	0	0	7739	1290	45	1	619	1	ING5	2	242662468	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	626891	242662468	536905	67	5771										
CHL1	10752	broad.mit.edu	37	chr3	403383	403383	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttatgttattttcaaatagaTgtccgtccattgatacaaac	5	7	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:403383T>A	uc003bou.2	+	12	1531	c.1260T>A	c.(1258-1260)GAT>GAA	p.D420E	CHL1_uc003bot.2_Missense_Mutation_p.D436E|CHL1_uc003bow.1_Missense_Mutation_p.D420E|CHL1_uc011asi.1_Missense_Mutation_p.D436E	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	420	Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTCAAATAGATGTCCGTCCAT	0.353													0	0	0	0.006122	0	17	161										A	403383	T	A	403383	3	1	20	1	0	0	0	0	1	0	0	0	3349	1478	51	5	1350	5	CHL1	3	403383	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08		403383	197619047	68	5772										
FANCD2	2177	broad.mit.edu	37	chr3	10133873	10133873	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggctgccccagattcatgaAgagaaactcctctactggaa	9	11	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:10133873A>C	uc003buw.2	+	38	3864	c.3786A>C	c.(3784-3786)GAA>GAC	p.E1262D	FANCD2_uc003bux.1_Missense_Mutation_p.E1262D|FANCD2_uc003buy.1_Missense_Mutation_p.E1262D|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1262					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGATTCATGAAGAGAAACTCC	0.418			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	64	303										C	10133873	A	C	10133873	3	2	20	1	0	0	0	0	1	0	0	0	5665	69	3	5	3932	5	FANCD2	3	10133873	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	9730490	10133873	187888557	69	5773										
SGOL1	151648	broad.mit.edu	37	chr3	20215950	20215950	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagactcgttgttttcttctCtattagagtcattgctcact	6	10	4	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:20215950C>G	uc003cbs.2	-	6	1260	c.1073G>C	c.(1072-1074)AGA>ACA	p.R358T	SGOL1_uc003cbr.2_Intron|SGOL1_uc010hfa.2_Intron|SGOL1_uc003cbt.2_Intron|SGOL1_uc003cbu.2_Missense_Mutation_p.R358T|SGOL1_uc003cbv.2_Intron|SGOL1_uc003cbw.2_Intron|SGOL1_uc003cbx.2_Intron|SGOL1_uc003cby.2_Intron|SGOL1_uc003cbz.2_Missense_Mutation_p.R358T|SGOL1_uc003cca.2_Missense_Mutation_p.R358T|SGOL1_uc003ccb.2_Intron|SGOL1_uc003ccc.2_Intron	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	358					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						GTTTTCTTCTCTATTAGAGTC	0.398													0	0	0	0.001855	0	13	109										G	20215950	C	G	20215950	3	3	20	1	0	0	0	0	1	0	0	0	14216	913	32	1	648	1	SGOL1	3	20215950	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	10082077	20215950	177806480	70	5774										
MYD88	4615	broad.mit.edu	37	chr3	38180222	38180222	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaggtcccggcgcggggtctGcggccccggtctcctccaca	15	17	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:38180222G>A	uc003chx.2	+	1	254	c.70G>A	c.(70-72)GCG>ACG	p.A24T	ACAA1_uc003cht.2_5'Flank|ACAA1_uc003chu.2_5'Flank|ACAA1_uc010hgy.2_5'Flank|ACAA1_uc010hgz.2_5'Flank|ACAA1_uc003chv.2_5'Flank|MYD88_uc011ayh.1_Missense_Mutation_p.A24T|MYD88_uc011ayi.1_Missense_Mutation_p.A24T|MYD88_uc011ayj.1_Missense_Mutation_p.A24T|MYD88_uc011ayk.1_Missense_Mutation_p.A24T|MYD88_uc011ayl.1_Missense_Mutation_p.A24T	NM_002468	NP_002459	Q99836	MYD88_HUMAN	myeloid differentiation primary response gene	11					3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(93)|breast(1)	94				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CGCGGGGTCTGCGGCCCCGGT	0.687			Mis 		ABC-DLBCL								0	0	0	0.006214	0	9	43										A	38180222	G	A	38180222	3	1	20	1	0	0	0	0	1	0	0	0	10023	1319	46	2	72	2	MYD88	3	38180222	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	17964272	38180222	159842208	71	5775										
XIRP1	165904	broad.mit.edu	37	chr3	39229444	39229444	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctatctgctctctgctaacaGaggtcagggcatggaggcgg	14	10	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:39229444G>C	uc003cjk.1	-	2	1714	c.1493C>G	c.(1492-1494)TCT>TGT	p.S498C	XIRP1_uc003cji.2_Missense_Mutation_p.S498C|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	498							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TCTGCTAACAGAGGTCAGGGC	0.592													0	0	0	0.004482	0	8	167										C	39229444	G	C	39229444	3	2	20	1	0	0	0	0	1	0	0	0	17426	942	33	1	4042	1	XIRP1	3	39229444	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1049222	39229444	158792986	72	5776										
ZNF167	55888	broad.mit.edu	37	chr3	44612226	44612226	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atagaaatctcattgaccatCagagaatccacactggggag	9	9	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:44612226C>T	uc010hin.2	+	6	2012	c.1624C>T	c.(1624-1626)CAG>TAG	p.Q542*	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Nonsense_Mutation_p.Q542*|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	542	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		CATTGACCATCAGAGAATCCA	0.453													0	0	0	0.006122	0	15	160										T	44612226	C	T	44612226	4	4	20	1	0	0	0	0	0	1	0	0	17738	827	29	1	1642	1	ZNF167	3	44612226	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5382782	44612226	153410204	73	5777										
ZNF35	7584	broad.mit.edu	37	chr3	44700861	44700861	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttacggaaaaatgctatgaaTgtaatgaatgtgggaaaaca	10	3	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:44700861T>C	uc003cnq.2	+	4	1227	c.1006T>C	c.(1006-1008)TGT>CGT	p.C336R	ZNF35_uc003cnr.2_Missense_Mutation_p.C176R	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	336	C2H2-type 5.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		ATGCTATGAATGTAATGAATG	0.428													0	0	0	0.001168	0	6	60										C	44700861	T	C	44700861	3	2	20	1	0	0	0	0	1	0	0	0	17859	1464	51	5	1016	5	ZNF35	3	44700861	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	88635	44700861	153321569	74	5778										
SCAP	22937	broad.mit.edu	37	chr3	47458631	47458631	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccttttgtccaagaacaccaGagcggtaatgcctgaggaga	11	10	0	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:47458631G>A	uc003crh.1	-	18	3292	c.3037C>T	c.(3037-3039)CTG>TTG	p.L1013L	SCAP_uc011baz.1_Silent_p.L757L|SCAP_uc003crg.2_Silent_p.L620L	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	1013	Interaction with SREBF2 (By similarity).|Cytoplasmic (By similarity).|WD 3.				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		AAGAACACCAGAGCGGTAATG	0.587													0	0	0	0.00245	0	13	60										A	47458631	G	A	47458631	2	1	20	1	0	0	0	0	0	0	0	1	13877	933	33	1		1	SCAP	3	47458631	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2757770	47458631	150563799	75	5779										
COL7A1	1294	broad.mit.edu	37	chr3	48605567	48605567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gccaacatctcctttttctcCtcggataccaggcactccat	5	16	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:48605567C>T	uc003ctz.2	-	105	7832	c.7831G>A	c.(7831-7833)GGA>AGA	p.G2611R		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2611	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCTTTTTCTCCTCGGATACCA	0.532													0	0	0	0.010504	0	16	83										T	48605567	C	T	48605567	3	4	20	1	0	0	0	0	1	0	0	0	3704	690	24	2	1059	2	COL7A1	3	48605567	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1146936	48605567	149416863	76	5780										
CELSR3	1951	broad.mit.edu	37	chr3	48687965	48687965	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggacgccaaactttgtctgGggccaccacacaccagatct	9	14	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:48687965G>T	uc003cul.2	-	16	6701	c.6420C>A	c.(6418-6420)CCC>CCA	p.P2140P	CELSR3_uc003cuf.1_Silent_p.P2210P|CELSR3_uc010hkg.2_Silent_p.P118P	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2140	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACTTTGTCTGGGGCCACCACA	0.617													1	0	5.9392e-07	0.001168	6.26992e-07	5	51										T	48687965	G	T	48687965	2	4	20	1	0	0	0	0	0	0	0	1	3223	1219	43	4		4	CELSR3	3	48687965	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	82398	48687965	149334465	77	5781										
DOCK3	1795	broad.mit.edu	37	chr3	51308411	51308411	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgcagtccattgccaggacaGtggatagccgcctgttttct	11	11	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:51308411G>T	uc011bds.1	+	24	2544	c.2521G>T	c.(2521-2523)GTG>TTG	p.V841L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	841						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGCCAGGACAGTGGATAGCCG	0.547													1	0	6.12954e-19	0.004656	6.92044e-19	22	196										T	51308411	G	T	51308411	3	4	20	1	0	0	0	0	1	0	0	0	4688	1029	36	4	2615	4	DOCK3	3	51308411	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2620446	51308411	146714019	78	5782										
GRM2	2912	broad.mit.edu	37	chr3	51750145	51750145	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttctatgtcacctccagtGactaccgggtgagctacctg	9	13	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:51750145G>A	uc010hlv.2	+	4	2595	c.2356G>A	c.(2356-2358)GAC>AAC	p.D786N	GRM2_uc003dbo.3_Missense_Mutation_p.D168N|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	786	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CACCTCCAGTGACTACCGGGT	0.532													0	0	0	0.009096	0	4	68										A	51750145	G	A	51750145	3	1	20	1	0	0	0	0	1	0	0	0	6797	1290	45	1	2366	1	GRM2	3	51750145	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	441734	51750145	146272285	79	5783										
SEMA3G	56920	broad.mit.edu	37	chr3	52473771	52473771	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcctggagagcgatgactttGagcacagaccctgagtctgg	14	10	1	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:52473771G>C	uc003dea.1	-	12	1392	c.1392C>G	c.(1390-1392)CTC>CTG	p.L464L		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	464	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CGATGACTTTGAGCACAGACC	0.632													0	0	0	0.00308	0	7	61										C	52473771	G	C	52473771	2	2	20	1	0	0	0	0	0	0	0	1	14030	1277	45	1		1	SEMA3G	3	52473771	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	723626	52473771	145548659	80	5784										
PBRM1	55193	broad.mit.edu	37	chr3	52643634	52643634	+	Frame_Shift_Del	DEL	T	T	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctgcgtgtttcaagcaggacTttgtgtagaacaagagcatc							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:52643634delT	uc003des.2	-	16	2274	c.2262delA	c.(2260-2262)AAAfs	p.K754fs	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Frame_Shift_Del_p.K754fs|PBRM1_uc003der.2_Frame_Shift_Del_p.K722fs|PBRM1_uc003det.2_Frame_Shift_Del_p.K769fs|PBRM1_uc003deu.2_Frame_Shift_Del_p.K769fs|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Frame_Shift_Del_p.K754fs|PBRM1_uc010hmk.1_Frame_Shift_Del_p.K754fs|PBRM1_uc003dey.2_Frame_Shift_Del_p.K754fs|PBRM1_uc003dez.1_Frame_Shift_Del_p.K754fs|PBRM1_uc003dfb.1_Frame_Shift_Del_p.K667fs|PBRM1_uc003dfa.1_Frame_Shift_Del_p.K100fs|PBRM1_uc003dfc.2_Frame_Shift_Del_p.K121fs	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	754					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CAAGCAGGACTTTGTGTAGAA	0.418			Mis|N|F|S|D|O		clear cell renal carcinoma|breast													8	113	---	---								-	52643634	T	-	52643634	7	5	20	1	0	1	0	1	0	0	0	0	11491	1606	56	0	2698	0	PBRM1	3	52643634	Frame_Shift_Del	DEL	T	TCGA-BT-A3PK-01A-21D-A21Z-08	169863	52643634	145378796	81	5785										
ITIH1	3697	broad.mit.edu	37	chr3	52814364	52814364	+	Frame_Shift_Del	DEL	C	C	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cctgccgaaggaactggcagCccaaactatcaagaagtcct							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:52814364delC	uc003dfs.2	+	6	677	c.653delC	c.(652-654)GCCfs	p.A218fs	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_5'Flank	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	218					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GAACTGGCAGCCCAAACTATC	0.527																		7	41	---	---								-	52814364	C	-	52814364	7	5	20	1	0	1	0	1	0	0	0	0	7903	739	26	0	675	0	ITIH1	3	52814364	Frame_Shift_Del	DEL	C	TCGA-BT-A3PK-01A-21D-A21Z-08	170730	52814364	145208066	82	5786										
PRKCD	5580	broad.mit.edu	37	chr3	53217515	53217515	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgccgcaccgcttcaaggtTcacaactacatgagccccac	7	16	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:53217515T>C	uc003dgl.2	+	9	1058	c.705T>C	c.(703-705)GTT>GTC	p.V235V	PRKCD_uc003dgm.2_Silent_p.V235V|PRKCD_uc010hmt.1_Silent_p.V7V	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	235	Phorbol-ester/DAG-type 2.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GCTTCAAGGTTCACAACTACA	0.592													0	0	0	0.012319	0	19	121										C	53217515	T	C	53217515	2	2	20	1	0	0	0	0	0	0	0	1	12509	1770	62	5		5	PRKCD	3	53217515	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	403151	53217515	144804915	83	5787										
C3orf63	23272	broad.mit.edu	37	chr3	56674101	56674101	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acgaaatccatgttcaatggGaacactgggacacaaactgc	9	10	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:56674101G>A	uc003did.3	-	16	2778	c.2677C>T	c.(2677-2679)CCC>TCC	p.P893S	C3orf63_uc003dic.3_Missense_Mutation_p.P497S|C3orf63_uc003die.3_Missense_Mutation_p.P893S	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	893										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		TGTTCAATGGGAACACTGGGA	0.323													0	0	0	0.001984	0	4	41										A	56674101	G	A	56674101	3	1	20	1	0	0	0	0	1	0	0	0	2239	1174	41	1	2431	1	C3orf63	3	56674101	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3456586	56674101	141348329	84	5788										
DZIP3	9666	broad.mit.edu	37	chr3	108355537	108355537	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgctgcaatgtgatgtaccTggaattgttaaaattttggt	10	4	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:108355537T>G	uc003dxd.2	+	11	1415	c.993T>G	c.(991-993)CCT>CCG	p.P331P	DZIP3_uc003dxf.1_Silent_p.P331P|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Silent_p.P331P|DZIP3_uc003dxg.1_Silent_p.P54P	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	331					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGATGTACCTGGAATTGTTA	0.313													0	0	0	0.003271	0	28	169										G	108355537	T	G	108355537	2	3	20	1	0	0	0	0	0	0	0	1	4865	1567	55	5		5	DZIP3	3	108355537	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	51681436	108355537	89666893	85	5789										
SLC9A10	285335	broad.mit.edu	37	chr3	111936346	111936346	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cccaattaagtagtagttttCtagcaaaggtaactgttttt	7	6	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:111936346C>T	uc003dyu.2	-	15	1955	c.1733G>A	c.(1732-1734)AGA>AAA	p.R578K	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.R530K	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	578					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TAGTAGTTTTCTAGCAAAGGT	0.303													0	0	0	0.001168	0	5	82										T	111936346	C	T	111936346	3	4	20	1	0	0	0	0	1	0	0	0	14710	913	32	1	1860	1	SLC9A10	3	111936346	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3580809	111936346	86086084	86	5790										
GSK3B	2932	broad.mit.edu	37	chr3	119720941	119720941	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgatggcgaccagttctccTgaatcacaaagtttggcttg	10	9	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:119720941T>C	uc003edo.2	-	2	1217	c.234A>G	c.(232-234)TCA>TCG	p.S78S	GSK3B_uc003edn.2_Silent_p.S78S	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2	78	Protein kinase.				axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	CCAGTTCTCCTGAATCACAAA	0.398													0	0	0	0.01441	0	42	224										C	119720941	T	C	119720941	2	2	20	1	0	0	0	0	0	0	0	1	6824	1567	55	5		5	GSK3B	3	119720941	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	7784595	119720941	78301489	87	5791										
SEMA5B	54437	broad.mit.edu	37	chr3	122667521	122667521	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caccatgataggcccctctgCagtcctagctccgggaggca	11	15	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:122667521C>T	uc003efz.1	-	3	464	c.160G>A	c.(160-162)GCA>ACA	p.A54T	SEMA5B_uc011bju.1_5'UTR|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.A54T|SEMA5B_uc010hro.1_5'UTR|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	54	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GGCCCCTCTGCAGTCCTAGCT	0.612													0	0	0	0.006214	0	6	52										T	122667521	C	T	122667521	3	4	20	1	0	0	0	0	1	0	0	0	14038	710	25	2	3379	2	SEMA5B	3	122667521	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2946580	122667521	75354909	88	5792										
SNX4	8723	broad.mit.edu	37	chr3	125166629	125166629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcaattcacaggattacatCttgctaaagcattccttagc	5	10	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:125166629C>T	uc003eib.2	-	14	1389	c.1347G>A	c.(1345-1347)AAG>AAA	p.K449K	SNX4_uc011bkf.1_Silent_p.K304K	NM_003794	NP_003785	O95219	SNX4_HUMAN	sorting nexin 4	449					cell communication|endocytic recycling|endocytosis|protein transport	cytoplasmic dynein complex|early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4						AGGATTACATCTTGCTAAAGC	0.313													0	0	0	0.014323	0	17	118										T	125166629	C	T	125166629	2	4	20	1	0	0	0	0	0	0	0	1	14904	912	32	1		1	SNX4	3	125166629	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2499108	125166629	72855801	89	5793										
A4GNT	51146	broad.mit.edu	37	chr3	137843160	137843160	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gacccctctgggcctttaatCaggtccctgtaagtcctggg	11	13	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:137843160C>T	uc003ers.2	-	3	1171	c.969G>A	c.(967-969)CTG>CTA	p.L323L		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	323	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						GGCCTTTAATCAGGTCCCTGT	0.522													0	0	0	0.001984	0	7	114										T	137843160	C	T	137843160	2	4	20	1	0	0	0	0	0	0	0	1	7	813	29	1		1	A4GNT	3	137843160	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	12676531	137843160	60179270	90	5794										
ZBTB38	253461	broad.mit.edu	37	chr3	141161237	141161237	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcctcttgtttcagatgacaGtcatgtccctttccagggac	8	12	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:141161237G>A	uc003etw.2	+	8	989	c.7G>A	c.(7-9)GTC>ATC	p.V3I	ZBTB38_uc010hun.2_5'UTR|ZBTB38_uc010huo.2_Missense_Mutation_p.V3I|ZBTB38_uc003ety.2_Missense_Mutation_p.V3I|ZBTB38_uc010hup.2_Missense_Mutation_p.V4I	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	3					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCAGATGACAGTCATGTCCCT	0.438													0	0	0	0.010504	0	19	121										A	141161237	G	A	141161237	3	1	20	1	0	0	0	0	1	0	0	0	17536	1029	36	2	9	2	ZBTB38	3	141161237	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3318077	141161237	56861193	91	5795										
ZBTB38	253461	broad.mit.edu	37	chr3	141163550	141163550	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgcaagcagacccaaaagcAttaaggagaaaaagaaaact	8	7	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:141163550A>G	uc003etw.2	+	8	3302	c.2320A>G	c.(2320-2322)ATT>GTT	p.I774V	ZBTB38_uc010hun.2_Missense_Mutation_p.I771V|ZBTB38_uc010huo.2_Missense_Mutation_p.I774V|ZBTB38_uc003ety.2_Missense_Mutation_p.I774V|ZBTB38_uc010hup.2_Missense_Mutation_p.I775V	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	774					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						ACCCAAAAGCATTAAGGAGAA	0.468													0	0	0	0.00308	0	6	39										G	141163550	A	G	141163550	3	3	20	1	0	0	0	0	1	0	0	0	17536	217	8	5	2322	5	ZBTB38	3	141163550	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2313	141163550	56858880	92	5796										
ATR	545	broad.mit.edu	37	chr3	142226809	142226809	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgttcctgaatattttgcttCttttctgtaataaatgattc	5	6	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:142226809C>T	uc003eux.3	-	28	5117	c.4995G>A	c.(4993-4995)AAG>AAA	p.K1665K		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1665	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TATTTTGCTTCTTTTCTGTAA	0.348								Other_conserved_DNA_damage_response_genes					0	0	0	0.006214	0	8	48										T	142226809	C	T	142226809	2	4	20	1	0	0	0	0	0	0	0	1	1204	912	32	1		1	ATR	3	142226809	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1063259	142226809	55795621	93	5797										
HPS3	84343	broad.mit.edu	37	chr3	148872982	148872982	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgtgaatacgatctcaccaGtgcagctgtacaaagagatg	10	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:148872982G>A	uc003ewu.1	+	8	1629	c.1489G>A	c.(1489-1491)GTG>ATG	p.V497M	HPS3_uc011bnq.1_Missense_Mutation_p.V332M	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	497						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GATCTCACCAGTGCAGCTGTA	0.333									Hermansky-Pudlak_syndrome				0	0	0	0.004007	0	14	84										A	148872982	G	A	148872982	3	1	20	1	0	0	0	0	1	0	0	0	7340	1029	36	2	1519	2	HPS3	3	148872982	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	6646173	148872982	49149448	94	5798										
CCNL1	57018	broad.mit.edu	37	chr3	156866286	156866286	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	taaggtgaggagaaccatgaTtatgatgtcttcgagggctt	13	5	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:156866286T>A	uc003fbf.2	-	11	1924	c.1325A>T	c.(1324-1326)AAT>ATT	p.N442I	CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_Missense_Mutation_p.N236I|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	442					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			AGAACCATGATTATGATGTCT	0.423													0	0	0	0.014323	0	21	124										A	156866286	T	A	156866286	3	1	20	1	0	0	0	0	1	0	0	0	2931	1493	52	5	259	5	CCNL1	3	156866286	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	7993304	156866286	41156144	95	5799										
SMC4	10051	broad.mit.edu	37	chr3	160138558	160138558	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gagccattgatgaaaaatacGacgtggctatatcatcctgt	9	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:160138558G>C	uc003fdh.2	+	13	2001	c.1888G>C	c.(1888-1890)GAC>CAC	p.D630H	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.D394H|SMC4_uc003fdi.2_Missense_Mutation_p.D605H|SMC4_uc003fdj.2_Missense_Mutation_p.D630H|SMC4_uc010hwd.2_Missense_Mutation_p.D630H|SMC4_uc003fdl.2_Missense_Mutation_p.D333H	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	630	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGAAAAATACGACGTGGCTAT	0.373													0	0	0	0.010504	0	18	133										C	160138558	G	C	160138558	3	2	20	1	0	0	0	0	1	0	0	0	14785	1058	37	1	1934	1	SMC4	3	160138558	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3272272	160138558	37883872	96	5800										
CCDC39	339829	broad.mit.edu	37	chr3	180359944	180359944	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	actgtgaagcatttctcgagTacgcttaacttcaagtttta	7	8	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:180359944T>G	uc010hxe.2	-	13	1826	c.1711A>C	c.(1711-1713)ACT>CCT	p.T571P	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	571	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATTTCTCGAGTACGCTTAACT	0.323													0	0	0	0.010729	0	10	24										G	180359944	T	G	180359944	3	3	20	1	0	0	0	0	1	0	0	0	2811	1638	57	5	1146	5	CCDC39	3	180359944	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	20221386	180359944	17662486	97	5801										
KLHL6	89857	broad.mit.edu	37	chr3	183217612	183217612	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggcttggtgcgttccgaaaTgatctggaaatcgatggggg	17	6	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:183217612T>A	uc003flr.2	-	4	971	c.913A>T	c.(913-915)ATT>TTT	p.I305F	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Intron	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	305										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CGTTCCGAAATGATCTGGAAA	0.363													0	0	0	0.001984	0	6	42										A	183217612	T	A	183217612	3	1	20	1	0	0	0	0	1	0	0	0	8393	1464	51	5	968	5	KLHL6	3	183217612	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	2857668	183217612	14804818	98	5802										
EPHB3	2049	broad.mit.edu	37	chr3	184299392	184299392	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cggctgcagatgaaccagacGctgcctgtgcaggtctgaca	13	12	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:184299392G>A	uc003foz.2	+	16	3416	c.2979G>A	c.(2977-2979)ACG>ACA	p.T993T		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	993	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGAACCAGACGCTGCCTGTGC	0.617													0	0	0	0.009096	0	3	29										A	184299392	G	A	184299392	2	1	20	1	0	0	0	0	0	0	0	1	5176	1074	38	2		2	EPHB3	3	184299392	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1081780	184299392	13723038	99	5803										
DGKG	1608	broad.mit.edu	37	chr3	185970927	185970927	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaggtcatttcctgttccaaGaggcaggacagccactggtg	12	10	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:185970927G>A	uc003fqa.2	-	18	2092	c.1555C>T	c.(1555-1557)CTT>TTT	p.L519F	DGKG_uc003fqb.2_Missense_Mutation_p.L480F|DGKG_uc003fqc.2_Missense_Mutation_p.L494F|DGKG_uc011brx.1_Missense_Mutation_p.L460F	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	519	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCTGTTCCAAGAGGCAGGACA	0.512													0	0	0	0.007413	0	15	126										A	185970927	G	A	185970927	3	1	20	1	0	0	0	0	1	0	0	0	4469	942	33	1	852	1	DGKG	3	185970927	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1671535	185970927	12051503	100	5804										
KIAA0226	9711	broad.mit.edu	37	chr3	197427591	197427591	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cctctgagaagctggacctgCggaggacactggacagctgg	15	11	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr3:197427591C>T	uc003fyc.2	-	7	1337	c.1154G>A	c.(1153-1155)CGC>CAC	p.R385H	KIAA0226_uc003fyd.3_Missense_Mutation_p.R325H|KIAA0226_uc003fye.1_Missense_Mutation_p.R92H|KIAA0226_uc003fyf.2_Missense_Mutation_p.R218H|KIAA0226_uc003fyg.2_Missense_Mutation_p.R378H	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	385	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GCTGGACCTGCGGAGGACACT	0.577													0	0	0	0.012319	0	22	85										T	197427591	C	T	197427591	3	4	20	1	0	0	0	0	1	0	0	0	8162	768	27	2	1869	2	KIAA0226	3	197427591	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	11456664	197427591	594839	101	5805										
FGFR3	2261	broad.mit.edu	37	chr4	1807559	1807559	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cggcggcccccgggcctggaCtactccttcgacacctgcaa	11	18	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:1807559C>T	uc003gdr.3	+	13	1984	c.1728C>T	c.(1726-1728)GAC>GAT	p.D576D	FGFR3_uc003gdu.2_Silent_p.D578D|FGFR3_uc003gds.3_Silent_p.D464D|FGFR3_uc003gdq.3_Silent_p.D577D	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	576	Protein kinase.|Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	cgggccTGGACTACTCCTTCG	0.567		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	35	159										T	1807559	C	T	1807559	2	4	20	1	0	0	0	0	0	0	0	1	5867	564	20	2		2	FGFR3	4	1807559	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		1807559	189346717	102	5806										
OTOP1	133060	broad.mit.edu	37	chr4	4199012	4199012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccctccccagctgctctcctCctgcttctcctcctccttgt	4	22	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:4199012C>T	uc003ghp.1	-	5	1579	c.1549G>A	c.(1549-1551)GAG>AAG	p.E517K		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	517					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTGCTCTCCTCCTGCTTCTCC	0.567													0	0	0	0.00308	0	8	80										T	4199012	C	T	4199012	3	4	20	1	0	0	0	0	1	0	0	0	11305	864	30	1	297	1	OTOP1	4	4199012	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2391453	4199012	186955264	103	5807										
GABRB1	2560	broad.mit.edu	37	chr4	47427924	47427924	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgtgcctcccagctcaaagtCaagatccccgacttgactga	8	15	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:47427924C>G	uc003gxh.2	+	9	1688	c.1314C>G	c.(1312-1314)GTC>GTG	p.V438V	GABRB1_uc011bze.1_Silent_p.V368V	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	438	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGCTCAAAGTCAAGATCCCCG	0.572													0	0	0	0.012319	0	20	157										G	47427924	C	G	47427924	2	3	20	1	0	0	0	0	0	0	0	1	6166	813	29	1		1	GABRB1	4	47427924	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	43228912	47427924	143726352	104	5808										
GC	2638	broad.mit.edu	37	chr4	72622632	72622632	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttactgtgtgttcaggcagCtacaaaacgaatggttagtt	10	6	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:72622632C>T	uc003hge.2	-	8	985	c.832_splice	c.e8-1	p.L278_splice	GC_uc003hgd.2_Splice_Site_p.L156_splice|GC_uc010iie.2_Splice_Site_p.L278_splice|GC_uc010iif.2_Splice_Site_p.L297_splice	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor						hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GTTCAGGCAGCTACAAAACGA	0.338													0	0	0	0.01441	0	54	84										T	72622632	C	T	72622632	5	4	20	1	0	0	0	0	0	0	1	0	6282	811	28	2	613	2	GC	4	72622632	Splice_Site	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	25194708	72622632	118531644	105	5809										
ANKRD17	26057	broad.mit.edu	37	chr4	73959821	73959821	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agtgattatccggtctccagTcttgtctttctgtttatcaa	7	9	5	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:73959821T>C	uc003hgp.2	-	28	5419	c.5302A>G	c.(5302-5304)ACT>GCT	p.T1768A	ANKRD17_uc003hgo.2_Missense_Mutation_p.T1655A|ANKRD17_uc003hgq.2_Missense_Mutation_p.T1517A|ANKRD17_uc003hgr.2_Missense_Mutation_p.T1767A	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1768	KH.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CGGTCTCCAGTCTTGTCTTTC	0.358													0	0	0	0.01441	0	139	120										C	73959821	T	C	73959821	3	2	20	1	0	0	0	0	1	0	0	0	646	1667	58	5	2537	5	ANKRD17	4	73959821	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	1337189	73959821	117194455	106	5810										
WDFY3	23001	broad.mit.edu	37	chr4	85678145	85678145	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgcaggttctcaggcagctcActaactggctgctgcagaaa	11	11	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:85678145A>T	uc003hpd.2	-	33	5766	c.5358T>A	c.(5356-5358)AGT>AGA	p.S1786R		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1786						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAGGCAGCTCACTAACTGGCT	0.502													0	0	0	0.013726	0	30	214										T	85678145	A	T	85678145	3	4	20	1	0	0	0	0	1	0	0	0	17267	156	6	5	5366	5	WDFY3	4	85678145	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	11718324	85678145	105476131	107	5811										
HERC6	55008	broad.mit.edu	37	chr4	89352340	89352340	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttattaatgaaatttgtccTgagtctggaggggttagttc	11	4	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:89352340T>A	uc011cdi.1	+	17	2316	c.2133T>A	c.(2131-2133)CCT>CCA	p.P711P	HERC6_uc011cdj.1_Silent_p.P675P|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	711	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		AAATTTGTCCTGAGTCTGGAG	0.373													0	0	0	0.003163	0	14	118										A	89352340	T	A	89352340	2	1	20	1	0	0	0	0	0	0	0	1	7062	1567	55	5		5	HERC6	4	89352340	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	3674195	89352340	101801936	108	5812										
GPRIN3	285513	broad.mit.edu	37	chr4	90169257	90169257	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagctggagcttggagtctgCgccaagctgctttttcttat	11	10	2	0	rs140505056		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:90169257C>T	uc003hsm.1	-	2	2524	c.2005G>A	c.(2005-2007)GCA>ACA	p.A669T		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	669										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TTGGAGTCTGCGCCAAGCTGC	0.547													0	0	0	0.006214	0	8	53										T	90169257	C	T	90169257	3	4	20	1	0	0	0	0	1	0	0	0	6731	768	27	2	329	2	GPRIN3	4	90169257	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	816917	90169257	100985019	109	5813										
BBS7	55212	broad.mit.edu	37	chr4	122782704	122782704	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgtttcaaaggagaggaacTgttttcctctttttgtgaag	10	5	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:122782704T>A	uc003ied.2	-	4	470	c.296A>T	c.(295-297)CAG>CTG	p.Q99L	BBS7_uc003iee.1_Missense_Mutation_p.Q99L|BBS7_uc010inq.1_Missense_Mutation_p.Q55L	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	99					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						GGAGAGGAACTGTTTTCCTCT	0.353									Bardet-Biedl_syndrome				0	0	0	0.006122	0	14	57										A	122782704	T	A	122782704	3	1	20	1	0	0	0	0	1	0	0	0	1341	1580	55	5	1920	5	BBS7	4	122782704	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	32613447	122782704	68371572	110	5814										
KIAA1109	84162	broad.mit.edu	37	chr4	123122253	123122253	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tataaagccacttaccacttCatctttgcacagaaaaactt	3	11	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:123122253C>T	uc003ieh.2	+	13	1515	c.1470C>T	c.(1468-1470)TTC>TTT	p.F490F	KIAA1109_uc003iei.1_Silent_p.F244F|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	490					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTTACCACTTCATCTTTGCAC	0.358													0	0	0	0.001168	0	4	72										T	123122253	C	T	123122253	2	4	20	1	0	0	0	0	0	0	0	1	8208	825	29	1		1	KIAA1109	4	123122253	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	339549	123122253	68032023	111	5815										
ADAD1	132612	broad.mit.edu	37	chr4	123317468	123317468	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaagaaagatttaatcaactAatttctaatcgttcagaata	4	5	3	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:123317468A>G	uc003ieo.2	+	7	892	c.660A>G	c.(658-660)CTA>CTG	p.L220L	ADAD1_uc003iep.2_Silent_p.L220L|ADAD1_uc003ieq.2_Silent_p.L202L	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	220					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TTAATCAACTAATTTCTAATC	0.284													0	0	0	0.008291	0	8	61										G	123317468	A	G	123317468	2	3	20	1	0	0	0	0	0	0	0	1	231	349	13	5		5	ADAD1	4	123317468	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	195215	123317468	67836808	112	5816										
MFSD8	256471	broad.mit.edu	37	chr4	128865042	128865060	+	Frame_Shift_Del	DEL	GTCTATAATTAGACCATAA	GTCTATAATTAGACCATAA	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aataagaggctcttttcttgGtctataattagaccataaac							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:128865042_128865060delGTCTATAATTAGACCATAA	uc003ifp.2	-	5	449_467	c.286_304delTTATGGTCTAATTATAGAC	c.(286-306)TTATGGTCTAATTATAGACCAfs	p.L96fs	MFSD8_uc011cgu.1_Frame_Shift_Del_p.L51fs|MFSD8_uc011cgv.1_Frame_Shift_Del_p.L96fs|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_Frame_Shift_Del_p.L51fs	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	96_102	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						TCTTTTCTTGGTCTATAATTAGACCATAAACCAAATATA	0.402																		11	109	---	---								-	128865060	GTCTATAATTAGACCATAA	-	128865042	7	5	20	1	0	1	0	1	0	0	0	0	9538	1261	44	0	1288	0	MFSD8	4	128865042	Frame_Shift_Del	DEL	GTCTATAATTAGACCATAA	TCGA-BT-A3PK-01A-21D-A21Z-08	5547574	128865042	62289234	113	5817										
LARP1B	55132	broad.mit.edu	37	chr4	129043216	129043216	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaaacatcctggaggagatcGaacaggcacccacatgtctc	9	12	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:129043216G>C	uc003iga.2	+	11	1528	c.1397G>C	c.(1396-1398)CGA>CCA	p.R466P	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.R466P|LARP1B_uc003igb.1_Missense_Mutation_p.R181P	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	466							RNA binding				0						GGAGGAGATCGAACAGGCACC	0.368													0	0	0	0.00278	0	19	114										C	129043216	G	C	129043216	3	2	20	1	0	0	0	0	1	0	0	0	8629	1058	37	1	1520	1	LARP1B	4	129043216	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	178174	129043216	62111060	114	5818										
PCDH18	54510	broad.mit.edu	37	chr4	138452557	138452557	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgcttatttttagtatggatGagccagacctctgaggtact	10	7	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:138452557G>A	uc003ihe.3	-	1	1073	c.686C>T	c.(685-687)TCA>TTA	p.S229L	PCDH18_uc003ihf.3_Missense_Mutation_p.S222L|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.S9L|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	229	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TAGTATGGATGAGCCAGACCT	0.463													0	0	0	0.001168	0	6	85										A	138452557	G	A	138452557	3	1	20	1	0	0	0	0	1	0	0	0	11513	1294	45	1	2737	1	PCDH18	4	138452557	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	9409341	138452557	52701719	115	5819										
SFRP2	6423	broad.mit.edu	37	chr4	154709870	154709870	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttggcagggatgggcttgcAattgctgcgcttgtaggaga	17	6	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:154709870A>T	uc003inv.1	-	1	359	c.118T>A	c.(118-120)TGC>AGC	p.C40S		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	40	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				ATGGGCTTGCAATTGCTGCGC	0.637													0	0	0	0.001855	0	8	108										T	154709870	A	T	154709870	3	4	20	1	0	0	0	0	1	0	0	0	14162	130	5	5	781	5	SFRP2	4	154709870	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	16257313	154709870	36444406	116	5820										
FNIP2	57600	broad.mit.edu	37	chr4	159782529	159782529	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttatattctgttccaaggaTagctgaacctgtatggctta	8	8	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:159782529T>C	uc003iqe.3	+	11	1367	c.1184T>C	c.(1183-1185)ATA>ACA	p.I395T		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	395					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		GTTCCAAGGATAGCTGAACCT	0.393													0	0	0	0.004672	0	3	38										C	159782529	T	C	159782529	3	2	20	1	0	0	0	0	1	0	0	0	5976	1406	49	5	1226	5	FNIP2	4	159782529	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	5072659	159782529	31371747	117	5821										
SCRG1	11341	broad.mit.edu	37	chr4	174312370	174312370	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttgcagtaacagatcatctCacatcccttcccatcccaga	5	15	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:174312370C>T	uc003ite.2	-	2	609	c.196G>A	c.(196-198)GAG>AAG	p.E66K	SCRG1_uc003itf.2_RNA	NM_007281	NP_009212	O75711	SCRG1_HUMAN	stimulator of chondrogenesis 1 precursor	66					nervous system development	extracellular space					0		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.15e-17)|Epithelial(43;4.33e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.62e-09)|STAD - Stomach adenocarcinoma(60;0.00278)|GBM - Glioblastoma multiforme(59;0.00659)|LUSC - Lung squamous cell carcinoma(193;0.0919)		CAGATCATCTCACATCCCTTC	0.438													0	0	0	0.003163	0	11	228										T	174312370	C	T	174312370	3	4	20	1	0	0	0	0	1	0	0	0	13936	835	29	1	108	1	SCRG1	4	174312370	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	14529841	174312370	16841906	118	5822										
FAT1	2195	broad.mit.edu	37	chr4	187541336	187541336	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caaattgctttttcagtgaaAtttcacccaagggtccaatt	6	9	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr4:187541336A>T	uc003izf.2	-	10	6592	c.6404T>A	c.(6403-6405)ATT>AAT	p.I2135N		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2135	Extracellular (Potential).|Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTTCAGTGAAATTTCACCCAA	0.423										HNSCC(5;0.00058)			0	0	0	0.007413	0	17	83										T	187541336	A	T	187541336	3	4	20	1	0	0	0	0	1	0	0	0	5689	101	4	5	7434	5	FAT1	4	187541336	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	13228966	187541336	3612940	119	5823										
SLC9A3	6550	broad.mit.edu	37	chr5	482240	482240	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgctcgctcctcttcaccttCagccactgcaccagaggctt	7	17	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:482240C>T	uc003jbe.2	-	8	1501	c.1389G>A	c.(1387-1389)CTG>CTA	p.L463L	SLC9A3_uc011clx.1_Silent_p.L454L	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	463	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TCTTCACCTTCAGCCACTGCA	0.701													0	0	0	0.010729	0	9	49										T	482240	C	T	482240	2	4	20	1	0	0	0	0	0	0	0	1	14713	813	29	1		1	SLC9A3	5	482240	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		482240	180433020	120	5824										
CLPTM1L	81037	broad.mit.edu	37	chr5	1338993	1338993	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acatcttcatgtaccgatgcAcatcggcaggcagggaggac	12	11	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:1338993A>T	uc003jch.2	-	4	627	c.581T>A	c.(580-582)GTG>GAG	p.V194E	CLPTM1L_uc003jcg.2_Missense_Mutation_p.V61E	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	194	Extracellular (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GTACCGATGCACATCGGCAGG	0.647													0	0	0	0.00333	0	21	139										T	1338993	A	T	1338993	3	4	20	1	0	0	0	0	1	0	0	0	3555	159	6	5	1091	5	CLPTM1L	5	1338993	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	856753	1338993	179576267	121	5825										
ADCY2	108	broad.mit.edu	37	chr5	7817000	7817000	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agcccgagcggcagtacatgCacattggcaccatggtggag	14	11	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:7817000C>T	uc003jdz.1	+	23	2972	c.2905C>T	c.(2905-2907)CAC>TAC	p.H969Y	ADCY2_uc011cmo.1_Missense_Mutation_p.H789Y|ADCY2_uc010itm.1_Missense_Mutation_p.H165Y	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	969	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GCAGTACATGCACATTGGCAC	0.517											OREG0016499	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	20	91										T	7817000	C	T	7817000	3	4	20	1	0	0	0	0	1	0	0	0	294	710	25	2	2995	2	ADCY2	5	7817000	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	6478007	7817000	173098260	122	5826										
DNAH5	1767	broad.mit.edu	37	chr5	13901509	13901509	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcatgggctgctgaatcctaTggaagagctggcgggcccac	15	11	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:13901509T>C	uc003jfd.2	-	14	1946	c.1904A>G	c.(1903-1905)CAT>CGT	p.H635R		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	635	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGAATCCTATGGAAGAGCTG	0.507									Kartagener_syndrome				0	0	0	0.00308	0	6	39										C	13901509	T	C	13901509	3	2	20	1	0	0	0	0	1	0	0	0	4604	1464	51	5	12234	5	DNAH5	5	13901509	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	6084509	13901509	167013751	123	5827										
KIF2A	3796	broad.mit.edu	37	chr5	61669661	61669661	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctaaaacttctttgtgaacaAaatgtgagtgtactatggtt	8	5	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:61669661A>C	uc003jsy.3	+	17	2105	c.1794A>C	c.(1792-1794)CAA>CAC	p.Q598H	KIF2A_uc003jsz.3_Missense_Mutation_p.Q636H|KIF2A_uc010iwp.2_Missense_Mutation_p.Q579H|KIF2A_uc003jsx.3_Missense_Mutation_p.Q578H|KIF2A_uc010iwq.2_Missense_Mutation_p.Q401H	NM_004520	NP_004511	O00139	KIF2A_HUMAN	kinesin heavy chain member 2 isoform 1	598					blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		TTTGTGAACAAAATGTGAGTG	0.383													0	0	0	0.004007	0	13	74										C	61669661	A	C	61669661	3	2	20	1	0	0	0	0	1	0	0	0	8297	11	1	5	1978	5	KIF2A	5	61669661	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	47768152	61669661	119245599	124	5828										
MAST4	375449	broad.mit.edu	37	chr5	66440574	66440574	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtggacaaaaccaaaagcacCaccttgccatccacagaaac	6	14	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:66440574C>A	uc003jut.1	+	21	2309	c.2241C>A	c.(2239-2241)ACC>ACA	p.T747T	MAST4_uc003juu.1_Silent_p.T757T|MAST4_uc011cra.1_Silent_p.T730T|MAST4_uc003juv.2_Silent_p.T742T|MAST4_uc003juw.2_Silent_p.T742T	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	939						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCAAAAGCACCACCTTGCCAT	0.398													1	0	0.00909568	0.009096	0.00921723	4	26										A	66440574	C	A	66440574	2	1	20	1	0	0	0	0	0	0	0	1	9327	581	21	4		4	MAST4	5	66440574	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	4770913	66440574	114474686	125	5829										
HOMER1	9456	broad.mit.edu	37	chr5	78692703	78692703	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agttctctggcattatcaatTtcttgttttaacctttctat	4	8	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:78692703T>G	uc003kfy.2	-	8	1922	c.819A>C	c.(817-819)GAA>GAC	p.E273D	HOMER1_uc010jab.2_Intron|HOMER1_uc010jac.2_Missense_Mutation_p.E143D|HOMER1_uc010jad.2_Missense_Mutation_p.E99D	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	273	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		CATTATCAATTTCTTGTTTTA	0.348													0	0	0	0.001984	0	6	19										G	78692703	T	G	78692703	3	3	20	1	0	0	0	0	1	0	0	0	7278	1838	64	5	253	5	HOMER1	5	78692703	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	12252129	78692703	102222557	126	5830										
ANKRD34B	340120	broad.mit.edu	37	chr5	79855446	79855446	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agaagaactttcagggtctcTgtatcttctgaatttatagc	8	7	4	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:79855446T>C	uc010jam.2	-	4	743	c.393A>G	c.(391-393)ACA>ACG	p.T131T	ANKRD34B_uc003kgw.2_Silent_p.T131T|ANKRD34B_uc010jan.2_Silent_p.T131T	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	131	ANK 4.					cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		TCAGGGTCTCTGTATCTTCTG	0.438													0	0	0	0.003954	0	23	131										C	79855446	T	C	79855446	2	2	20	1	0	0	0	0	0	0	0	1	663	1567	55	5		5	ANKRD34B	5	79855446	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	1162743	79855446	101059814	127	5831										
VCAN	1462	broad.mit.edu	37	chr5	82832894	82832894	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctaaagaagatgaaccttgtAgtgaagaaacagatccagtg	10	6	0	6	rs142339468		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:82832894A>G	uc003kii.3	+	8	4428	c.4072A>G	c.(4072-4074)AGT>GGT	p.S1358G	VCAN_uc003kij.3_Missense_Mutation_p.S371G|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.S22G	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1358	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGAACCTTGTAGTGAAGAAAC	0.318													0	0	0	0.010729	0	9	98										G	82832894	A	G	82832894	3	3	20	1	0	0	0	0	1	0	0	0	17135	420	15	5	4098	5	VCAN	5	82832894	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2977448	82832894	98082366	128	5832										
TTC37	9652	broad.mit.edu	37	chr5	94845328	94845328	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catttgctgcttcctttttcAgttgtagatgttcgtttaag	8	7	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:94845328A>T	uc003klb.2	-	29	3254	c.2984T>A	c.(2983-2985)CTG>CAG	p.L995Q		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	995	TPR 16.						binding			ovary(3)|pancreas(1)	4						TTCCTTTTTCAGTTGTAGATG	0.239													0	0	0	0.00308	0	6	49										T	94845328	A	T	94845328	3	4	20	1	0	0	0	0	1	0	0	0	16702	188	7	5	1770	5	TTC37	5	94845328	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	12012434	94845328	86069932	129	5833										
CCNI2	645121	broad.mit.edu	37	chr5	132083140	132083140	+	Translation_Start_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgttccgggagctgggttatAaaatgccgggttaagcggca	15	7	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:132083140A>G	uc003kxq.1	+	1	4	c.-47A>G	c.(-49--45)ATAAA>ATGAA		CCNI2_uc011cxg.1_Translation_Start_Site|CCNI2_uc011cxh.1_Translation_Start_Site	NM_001039780	NP_001034869	Q6ZMN8	CCNI2_HUMAN	cyclin I family, member 2						regulation of cyclin-dependent protein kinase activity		protein kinase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTGGGTTATAAAATGCCGGG	0.701													0	0	0	0.004672	0	2	5										G	132083140	A	G	132083140	1	3	20	1	0	0	0	0	0	0	0	0	2927	377	13	5		5	CCNI2	5	132083140	Translation_Start_Site	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	37237812	132083140	48832120	130	5834										
AFF4	27125	broad.mit.edu	37	chr5	132228738	132228738	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtactctctgttgctggatgGcttatggcctgctgaattct	11	9	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:132228738G>C	uc003kyd.2	-	12	2788	c.2380C>G	c.(2380-2382)CCA>GCA	p.P794A	AFF4_uc011cxk.1_Missense_Mutation_p.P472A|AFF4_uc003kye.1_Missense_Mutation_p.P794A	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	794					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGCTGGATGGCTTATGGCCT	0.423													0	0	0	0.01441	0	65	402										C	132228738	G	C	132228738	3	2	20	1	0	0	0	0	1	0	0	0	359	1203	42	4	1151	4	AFF4	5	132228738	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	145598	132228738	48686522	131	5835										
FSTL4	23105	broad.mit.edu	37	chr5	132552957	132552957	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcttggatgtcgaccacaagGactctgctcagtgctggctg	13	11	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:132552957G>T	uc003kyn.1	-	13	1790	c.1572C>A	c.(1570-1572)GTC>GTA	p.V524V	FSTL4_uc003kym.1_Silent_p.V173V	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	524						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CGACCACAAGGACTCTGCTCA	0.507													1	0	2.79863e-10	0.004656	3.061e-10	19	102										T	132552957	G	T	132552957	2	4	20	1	0	0	0	0	0	0	0	1	6079	1161	41	3		3	FSTL4	5	132552957	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	324219	132552957	48362303	132	5836										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139917005	139917005	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccaccaacgttgggccaaccAaaaggagtcagtgccagtca	10	13	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:139917005A>G	uc003lfs.1	+	31	7183	c.7059A>G	c.(7057-7059)CCA>CCG	p.P2353P	ANKHD1_uc003lfr.2_Silent_p.P2353P|ANKHD1-EIF4EBP3_uc011czh.1_Silent_p.P1109P|ANKHD1_uc003lfw.2_Silent_p.P1008P|ANKHD1_uc010jfl.2_Silent_p.P729P|ANKHD1-EIF4EBP3_uc003lfx.1_Silent_p.P507P	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2353						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCCAACCAAAAGGAGTCA	0.522													0	0	0	0.006999	0	35	149										G	139917005	A	G	139917005	2	3	20	1	0	0	0	0	0	0	0	1	629	117	5	5		5	ANKHD1-EIF4EBP3	5	139917005	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	7364048	139917005	40998255	133	5837										
PCDHA10	56139	broad.mit.edu	37	chr5	140236270	140236270	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agctaaagttgttgttgacaGcaactgatggaggcaaacct	11	7	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:140236270G>A	uc003lhx.2	+	1	637	c.637G>A	c.(637-639)GCA>ACA	p.A213T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.A213T|PCDHA10_uc011dad.1_Missense_Mutation_p.A213T	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	213	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGTTGACAGCAACTGATGG	0.423													0	0	0	0.00333	0	21	143										A	140236270	G	A	140236270	3	1	20	1	0	0	0	0	1	0	0	0	11520	971	34	2	639	2	PCDHA10	5	140236270	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	319265	140236270	40678990	134	5838										
PCDHB7	56129	broad.mit.edu	37	chr5	140552984	140552984	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgatagcggggaggggaatAtctatcccgaattggtgctg	15	6	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:140552984A>G	uc003lit.2	+	1	742	c.568A>G	c.(568-570)ATC>GTC	p.I190V		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	190	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGGGAATATCTATCCCGA	0.488													0	0	0	0.007413	0	16	66										G	140552984	A	G	140552984	3	3	20	1	0	0	0	0	1	0	0	0	11547	449	16	5	570	5	PCDHB7	5	140552984	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	316714	140552984	40362276	135	5839										
PCDHGA7	56108	broad.mit.edu	37	chr5	140764040	140764040	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atcctttgattatgagcagtTgagagaactacaactaagag	9	6	0	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:140764040T>A	uc003lka.1	+	1	1574	c.1574T>A	c.(1573-1575)TTG>TAG	p.L525*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Nonsense_Mutation_p.L525*	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	525	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATGAGCAGTTGAGAGAACTA	0.532													0	0	0	0.000602	0	5	67										A	140764040	T	A	140764040	4	1	20	1	0	0	0	0	0	1	0	0	11559	1821	63	5	1576	5	PCDHGA7	5	140764040	Nonsense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	211056	140764040	40151220	136	5840										
CSNK1A1	1452	broad.mit.edu	37	chr5	148929685	148929685	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaagaatcttatagagcttGctctcgtacagcaactgggg	11	8	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:148929685G>T	uc003lqx.1	-	2	663	c.183C>A	c.(181-183)AGC>AGA	p.S61R	CSNK1A1_uc011dcc.1_5'UTR|CSNK1A1_uc003lqv.1_5'UTR|CSNK1A1_uc003lqw.1_Missense_Mutation_p.S61R|CSNK1A1_uc003lqy.1_Missense_Mutation_p.S61R|CSNK1A1_uc010jha.1_Missense_Mutation_p.S61R	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	61	Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		TATAGAGCTTGCTCTCGTACA	0.542													1	0	6.94344e-10	0.006122	7.54002e-10	14	167										T	148929685	G	T	148929685	3	4	20	1	0	0	0	0	1	0	0	0	3950	1310	46	4	954	4	CSNK1A1	5	148929685	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	8165645	148929685	31985575	137	5841										
RMND5B	64777	broad.mit.edu	37	chr5	177573138	177573138	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tccaggtgatgatgggcagcCtggtgtacctgcggctgggc	17	10	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:177573138C>T	uc003mim.2	+	8	898	c.718C>T	c.(718-720)CTG>TTG	p.L240L	RMND5B_uc003min.2_Silent_p.L240L|RMND5B_uc003mio.2_Silent_p.L227L|RMND5B_uc003mip.2_Silent_p.L240L|RMND5B_uc011dgf.1_Silent_p.L281L|RMND5B_uc003miq.2_Silent_p.L180L	NM_022762	NP_073599	Q96G75	RMD5B_HUMAN	required for meiotic nuclear division 5 homolog	240										ovary(1)|skin(1)	2	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGGGCAGCCTGGTGTACCT	0.642											OREG0017097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	7	48										T	177573138	C	T	177573138	2	4	20	1	0	0	0	0	0	0	0	1	13398	680	24	2		2	RMND5B	5	177573138	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	28643453	177573138	3342122	138	5842										
AGXT2L2	85007	broad.mit.edu	37	chr5	177640080	177640080	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcccagggccatcagtgctCagcaaaacgtagttctcctt	8	14	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:177640080C>G	uc003miz.2	-	11	1449	c.1197G>C	c.(1195-1197)CTG>CTC	p.L399L	AGXT2L2_uc003miy.2_Silent_p.L124L|AGXT2L2_uc003mjc.2_Silent_p.L358L|AGXT2L2_uc003mja.2_Intron|AGXT2L2_uc003mjb.2_Silent_p.L124L|AGXT2L2_uc003mjd.1_Silent_p.L257L	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	399						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	CATCAGTGCTCAGCAAAACGT	0.567													0	0	0	0.008291	0	7	101										G	177640080	C	G	177640080	2	3	20	1	0	0	0	0	0	0	0	1	407	813	29	1		1	AGXT2L2	5	177640080	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	66942	177640080	3275180	139	5843										
ADAMTS2	9509	broad.mit.edu	37	chr5	178552080	178552080	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcttggcgtgcacggagcggGtggtgttgtcgtgtagcggc	20	8	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:178552080G>T	uc003mjw.2	-	19	2852	c.2852C>A	c.(2851-2853)ACC>AAC	p.T951N		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	951	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CACGGAGCGGGTGGTGTTGTC	0.697													1	0	4.06502e-11	0.013114	4.45683e-11	38	220										T	178552080	G	T	178552080	3	4	20	1	0	0	0	0	1	0	0	0	265	1261	44	4	799	4	ADAMTS2	5	178552080	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	912000	178552080	2363180	140	5844										
TBC1D9B	23061	broad.mit.edu	37	chr5	179294465	179294465	+	Frame_Shift_Del	DEL	A	A	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttgagcctcccagggcaggAaaagatccagatctgaggcc							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr5:179294465delA	uc003mlh.2	-	19	2931	c.2894delT	c.(2893-2895)TTCfs	p.F965fs	TBC1D9B_uc003mli.2_Intron|TBC1D9B_uc003mlj.2_Intron|TBC1D9B_uc003mlf.2_5'Flank|TBC1D9B_uc003mlg.2_Intron|TBC1D9B_uc011dgv.1_Intron|TBC1D9B_uc011dgw.1_Frame_Shift_Del_p.F235fs	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	965						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCAGGGCAGGAAAAGATCCAG	0.597																		5	9	---	---								-	179294465	A	-	179294465	7	5	20	1	0	1	0	1	0	0	0	0	15625	246	9	0	874	0	TBC1D9B	5	179294465	Frame_Shift_Del	DEL	A	TCGA-BT-A3PK-01A-21D-A21Z-08	742385	179294465	1620795	141	5845										
DSP	1832	broad.mit.edu	37	chr6	7586077	7586077	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaattcttcctactcttattCctactcatttagcagtagtt	4	10	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:7586077C>A	uc003mxp.1	+	24	8861	c.8582C>A	c.(8581-8583)TCC>TAC	p.S2861Y	DSP_uc003mxq.1_Missense_Mutation_p.S2262Y	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2861	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TACTCTTATTCCTACTCATTT	0.313													1	0	5.3912e-06	0.006122	5.67824e-06	13	172										A	7586077	C	A	7586077	3	1	20	1	0	0	0	0	1	0	0	0	4781	855	30	3	8676	3	DSP	6	7586077	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		7586077	163528990	142	5846										
SNRNP48	154007	broad.mit.edu	37	chr6	7602960	7602960	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccaagaatgttcacataaccAagaaatcatatactgaggta	6	8	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:7602960A>G	uc003mxr.2	+	6	759	c.700A>G	c.(700-702)AAG>GAG	p.K234E	SNRNP48_uc003mxs.2_RNA|SNRNP48_uc003mxt.1_5'UTR	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	234					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						TCACATAACCAAGAAATCATA	0.333													0	0	0	0.00308	0	6	47										G	7602960	A	G	7602960	3	3	20	1	0	0	0	0	1	0	0	0	14857	131	5	5	722	5	SNRNP48	6	7602960	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	16883	7602960	163512107	143	5847										
SLC35B3	51000	broad.mit.edu	37	chr6	8422784	8422784	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggtagggtaattcaggtagcCcaaggaagtgtttgataacc	13	6	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:8422784C>A	uc010joe.2	-	5	659	c.493G>T	c.(493-495)GGC>TGC	p.G165C	SLC35B3_uc003mya.2_Missense_Mutation_p.G133C|SLC35B3_uc003myc.2_Intron|SLC35B3_uc003myb.2_Missense_Mutation_p.G165C|SLC35B3_uc011did.1_Missense_Mutation_p.G165C|SLC35B3_uc003myd.2_RNA	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	165	Helical; (Potential).				transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)					TTCAGGTAGCCCAAGGAAGTG	0.358													1	0	4.35082e-09	0.010504	4.67996e-09	16	66										A	8422784	C	A	8422784	3	1	20	1	0	0	0	0	1	0	0	0	14577	623	22	4	740	4	SLC35B3	6	8422784	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	819824	8422784	162692283	144	5848										
HIST1H4I	8294	broad.mit.edu	37	chr6	27107349	27107349	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cggtcaccgccatggacgtgGtctacgcgctcaagcgccag	13	15	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:27107349G>T	uc003niy.1	+	1	262	c.262G>T	c.(262-264)GTC>TTC	p.V88F	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	88					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CATGGACGTGGTCTACGCGCT	0.602			T	BCL6	NHL								1	0	1.05317e-09	0.00245	1.14093e-09	10	88										T	27107349	G	T	27107349	3	4	20	1	0	0	0	0	1	0	0	0	7173	1261	44	4	264	4	HIST1H4I	6	27107349	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	18684565	27107349	144007718	145	5849										
PGBD1	84547	broad.mit.edu	37	chr6	28269267	28269267	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggaagaatactattgctttGataagtcaatgtgtgaatgc	10	4	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:28269267G>A	uc003nky.2	+	7	2006	c.1636G>A	c.(1636-1638)GAT>AAT	p.D546N	PGBD1_uc003nkz.2_Missense_Mutation_p.D546N	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	546					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CTATTGCTTTGATAAGTCAAT	0.348													0	0	0	0.006122	0	17	144										A	28269267	G	A	28269267	3	1	20	1	0	0	0	0	1	0	0	0	11780	1290	45	1	1658	1	PGBD1	6	28269267	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1161918	28269267	142845800	146	5850										
PGBD1	84547	broad.mit.edu	37	chr6	28269301	28269301	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaatgctttgatagtgaccAattcctgaatggaaagccta	9	7	0	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:28269301A>G	uc003nky.2	+	7	2040	c.1670A>G	c.(1669-1671)CAA>CGA	p.Q557R	PGBD1_uc003nkz.2_Missense_Mutation_p.Q557R	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	557					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						GATAGTGACCAATTCCTGAAT	0.363													0	0	0	0.00245	0	14	116										G	28269301	A	G	28269301	3	3	20	1	0	0	0	0	1	0	0	0	11780	130	5	5	1692	5	PGBD1	6	28269301	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	34	28269301	142845766	147	5851										
MDC1	9656	broad.mit.edu	37	chr6	30680687	30680687	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcctcttcttcataggaatGacaactggggttgctgggat	11	8	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:30680687G>A	uc003nrg.3	-	5	1472	c.1032C>T	c.(1030-1032)GTC>GTT	p.V344V	MDC1_uc003nrf.3_5'UTR|MDC1_uc011dmp.1_Silent_p.V216V|MDC1_uc003nrh.1_Silent_p.V216V|MDC1_uc003nri.2_Silent_p.V344V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	344	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TCATAGGAATGACAACTGGGG	0.547								Other_conserved_DNA_damage_response_genes					0	0	0	0.006122	0	18	113										A	30680687	G	A	30680687	2	1	20	1	0	0	0	0	0	0	0	1	9403	1277	45	1		1	MDC1	6	30680687	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2411386	30680687	140434380	148	5852										
IP6K3	117283	broad.mit.edu	37	chr6	33690810	33690810	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	taatgacagagaggagggccCggagctggtgcaggatgggc	19	7	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:33690810C>T	uc010jvf.2	-	7	1456	c.920G>A	c.(919-921)CGG>CAG	p.R307Q	IP6K3_uc003ofb.2_Missense_Mutation_p.R307Q	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	307					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						GAGGAGGGCCCGGAGCTGGTG	0.552													0	0	0	0.00245	0	12	54										T	33690810	C	T	33690810	3	4	20	1	0	0	0	0	1	0	0	0	7790	652	23	2	316	2	IP6K3	6	33690810	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3010123	33690810	137424257	149	5853										
KCNK5	8645	broad.mit.edu	37	chr6	39159465	39159465	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaagggacagccaggccagcCccaagtagatccagagctcc	11	14	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:39159465C>A	uc003oon.2	-	5	1065	c.701G>T	c.(700-702)GGG>GTG	p.G234V		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	234	Helical; (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CCAGGCCAGCCCCAAGTAGAT	0.577													1	0	1.10923e-09	0.00278	1.19881e-09	22	180										A	39159465	C	A	39159465	3	1	20	1	0	0	0	0	1	0	0	0	8069	623	22	4	802	4	KCNK5	6	39159465	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5468655	39159465	131955602	150	5854										
CUL9	23113	broad.mit.edu	37	chr6	43152278	43152278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaggtctacgccaactgccCtgggctgttaggtgagcggg	16	10	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:43152278C>T	uc003ouk.2	+	2	305	c.230C>T	c.(229-231)CCT>CTT	p.P77L	CUL9_uc003ouj.1_Missense_Mutation_p.P77L|CUL9_uc003oul.2_Missense_Mutation_p.P77L|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	77					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GCCAACTGCCCTGGGCTGTTA	0.572													0	0	0	0.00308	0	6	91										T	43152278	C	T	43152278	3	4	20	1	0	0	0	0	1	0	0	0	4061	681	24	2	232	2	CUL9	6	43152278	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3992813	43152278	127962789	151	5855										
ZNF318	24149	broad.mit.edu	37	chr6	43305708	43305708	+	Frame_Shift_Del	DEL	C	C	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	attccccagggcagtaagctCctctacctttaagtctgtag							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:43305708delC	uc003oux.2	-	10	6106	c.6028delG	c.(6028-6030)GAGfs	p.E2010fs	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2010					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCAGTAAGCTCCTCTACCTTT	0.473																		8	109	---	---								-	43305708	C	-	43305708	7	5	20	1	0	1	0	1	0	0	0	0	17833	864	30	0	815	0	ZNF318	6	43305708	Frame_Shift_Del	DEL	C	TCGA-BT-A3PK-01A-21D-A21Z-08	153430	43305708	127809359	152	5856										
C6orf138	442213	broad.mit.edu	37	chr6	47846771	47846771	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agatacaagcgagaagcaatGatattgctttcatcccctgc	8	10	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:47846771G>C	uc011dwm.1	-	3	1843	c.1758C>G	c.(1756-1758)ATC>ATG	p.I586M	C6orf138_uc011dwn.1_Missense_Mutation_p.I350M	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	603						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						GAGAAGCAATGATATTGCTTT	0.433													0	0	0	0.001168	0	6	53										C	47846771	G	C	47846771	3	2	20	1	0	0	0	0	1	0	0	0	2332	1280	45	1	735	1	C6orf138	6	47846771	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4541063	47846771	123268296	153	5857										
MUT	4594	broad.mit.edu	37	chr6	49416588	49416588	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caattcgaagtttaggtattCcctcagctacagctttggcc	8	11	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:49416588C>T	uc003ozg.3	-	7	1640	c.1385G>A	c.(1384-1386)GGA>GAA	p.G462E		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	462					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTTAGGTATTCCCTCAGCTAC	0.333													0	0	0	0.014323	0	16	227										T	49416588	C	T	49416588	3	4	20	1	0	0	0	0	1	0	0	0	9991	855	30	1	895	1	MUT	6	49416588	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1569817	49416588	121698479	154	5858										
PKHD1	5314	broad.mit.edu	37	chr6	51612779	51612779	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctttgtcctgaatgcagtcaAaagaagagctggtggccaca	11	9	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:51612779A>G	uc003pah.1	-	58	9911	c.9635T>C	c.(9634-9636)TTT>TCT	p.F3212S	PKHD1_uc010jzn.1_Missense_Mutation_p.F1195S|PKHD1_uc003pai.2_Missense_Mutation_p.F3212S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3212	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AATGCAGTCAAAAGAAGAGCT	0.448													0	0	0	0.00333	0	22	128										G	51612779	A	G	51612779	3	3	20	1	0	0	0	0	1	0	0	0	11971	14	1	5	2668	5	PKHD1	6	51612779	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2196191	51612779	119502288	155	5859										
PKHD1	5314	broad.mit.edu	37	chr6	51824704	51824704	+	Missense_Mutation	SNP	T	T	A													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttgaggatgcttgtgttagTgtccagcagaagcaattggc							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:51824704T>A	uc003pah.1	-	36	6148	c.5872A>T	c.(5872-5874)ACT>TCT	p.T1958S	PKHD1_uc003pai.2_Missense_Mutation_p.T1958S	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1958	Extracellular (Potential).|G8 1.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTTGTGTTAGTGTCCAGCAGA	0.463											OREG0017492	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	18	210										A	51824704	T	A	51824704	3	1	20	1	0	0	0	0	1	0	0	0	11971	1696	59	5	6519	5	PKHD1	6	51824704	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	211925	51824704	119290363	156	5860	27	2								
PKHD1	5314	broad.mit.edu	37	chr6	51824706	51824706	+	Missense_Mutation	SNP	T	T	C													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaggatgcttgtgttagtgTccagcagaagcaattggcca							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:51824706T>C	uc003pah.1	-	36	6146	c.5870A>G	c.(5869-5871)GAC>GGC	p.D1957G	PKHD1_uc003pai.2_Missense_Mutation_p.D1957G	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1957	Extracellular (Potential).|G8 1.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TGTGTTAGTGTCCAGCAGAAG	0.453											OREG0017492	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	16	210										C	51824706	T	C	51824706	3	2	20	1	0	0	0	0	1	0	0	0	11971	1667	58	5	6521	5	PKHD1	6	51824706	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	2	51824706	119290361	157	5861	27	2								
HTR1E	3354	broad.mit.edu	37	chr6	87725847	87725847	+	Frame_Shift_Del	DEL	C	C	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttccatgcctccatcaggatCccccccttcgacaatgatct							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:87725847delC	uc003pli.2	+	2	1498	c.795delC	c.(793-795)ATCfs	p.I265fs		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	265	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CCATCAGGATCCCCCCCTTCG	0.512																		7	322	---	---								-	87725847	C	-	87725847	7	5	20	1	0	1	0	1	0	0	0	0	7439	845	30	0	797	0	HTR1E	6	87725847	Frame_Shift_Del	DEL	C	TCGA-BT-A3PK-01A-21D-A21Z-08	35901141	87725847	83389220	158	5862										
FIG4	9896	broad.mit.edu	37	chr6	110106228	110106228	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atttaccattgccctatgatGaaggtaggtaactgtttgtg	10	6	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:110106228G>A	uc003ptt.2	+	17	2160	c.1945G>A	c.(1945-1947)GAA>AAA	p.E649K	FIG4_uc011eau.1_Missense_Mutation_p.E372K	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	649					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GCCCTATGATGAAGGTAGGTA	0.289													0	0	0	0.00278	0	18	183										A	110106228	G	A	110106228	3	1	20	1	0	0	0	0	1	0	0	0	5888	1291	45	1	2011	1	FIG4	6	110106228	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	22380381	110106228	61008839	159	5863										
MAN1A1	4121	broad.mit.edu	37	chr6	119669755	119669755	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccttgtcacgcagctggtccTgggccaccttcttcttctcc	8	17	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:119669755T>C	uc003pym.1	-	2	918	c.476A>G	c.(475-477)CAG>CGG	p.Q159R	MAN1A1_uc010kei.1_Missense_Mutation_p.Q159R	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	159	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		CAGCTGGTCCTGGGCCACCTT	0.652													0	0	0	0.008291	0	9	97										C	119669755	T	C	119669755	3	2	20	1	0	0	0	0	1	0	0	0	9210	1580	55	5	1533	5	MAN1A1	6	119669755	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	9563527	119669755	51445312	160	5864										
HSF2	3298	broad.mit.edu	37	chr6	122733867	122733867	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaatttcagcatccttacttCaaacaaggacaggatgactt	7	9	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:122733867C>G	uc003pyu.2	+	3	475	c.288C>G	c.(286-288)TTC>TTG	p.F96L	HSF2_uc003pyt.3_Missense_Mutation_p.F96L|HSF2_uc003pyv.2_Missense_Mutation_p.F96L	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	96	By similarity.				response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		ATCCTTACTTCAAACAAGGAC	0.398													0	0	0	0.001984	0	7	133										G	122733867	C	G	122733867	3	3	20	1	0	0	0	0	1	0	0	0	7396	825	29	1	298	1	HSF2	6	122733867	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3064112	122733867	48381200	161	5865										
CTGF	1490	broad.mit.edu	37	chr6	132270442	132270442	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catcttcctgtagtacagcgAttcaaagatgtcattgtctc	7	10	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:132270442A>G	uc003qcz.2	-	5	1218	c.1012T>C	c.(1012-1014)TCG>CCG	p.S338P		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	338	Heparin-binding.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		TAGTACAGCGATTCAAAGATG	0.453													0	0	0	0.00499	0	14	109										G	132270442	A	G	132270442	3	3	20	1	0	0	0	0	1	0	0	0	4008	333	12	5	41	5	CTGF	6	132270442	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	9536575	132270442	38844625	162	5866										
AHI1	54806	broad.mit.edu	37	chr6	135787429	135787429	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tagtgactctcgtgctcttcTtcaggttgttagtgttagca	10	8	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:135787429T>C	uc003qgi.2	-	7	656	c.272A>G	c.(271-273)AAG>AGG	p.K91R	AHI1_uc003qgh.2_Missense_Mutation_p.K91R|AHI1_uc003qgj.2_Missense_Mutation_p.K91R|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Missense_Mutation_p.K91R	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	91						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		CGTGCTCTTCTTCAGGTTGTT	0.393													0	0	0	0.007291	0	27	229										C	135787429	T	C	135787429	3	2	20	1	0	0	0	0	1	0	0	0	413	1609	56	5	3467	5	AHI1	6	135787429	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	3516987	135787429	35327638	163	5867										
TNFAIP3	7128	broad.mit.edu	37	chr6	138198260	138198260	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gagaccggggaagatttgaaGacttaaaagttcactttttg	11	5	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:138198260G>A	uc003qhr.2	+	6	919	c.853G>A	c.(853-855)GAC>AAC	p.D285N	TNFAIP3_uc003qhs.2_Missense_Mutation_p.D285N	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	285	TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AAGATTTGAAGACTTAAAAGT	0.373			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								0	0	0	0.010729	0	11	98										A	138198260	G	A	138198260	3	1	20	1	0	0	0	0	1	0	0	0	16271	942	33	1	871	1	TNFAIP3	6	138198260	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2410831	138198260	32916807	164	5868										
PLEKHG1	57480	broad.mit.edu	37	chr6	151152027	151152027	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gctggcatatgggacagatgGagtccacagagacctccagc	13	11	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:151152027G>A	uc003qny.1	+	16	2092	c.1780G>A	c.(1780-1782)GAG>AAG	p.E594K	PLEKHG1_uc011eel.1_Missense_Mutation_p.E634K|PLEKHG1_uc011eem.1_Missense_Mutation_p.E653K|PLEKHG1_uc003qnz.2_Missense_Mutation_p.E594K	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	594					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GGGACAGATGGAGTCCACAGA	0.532													0	0	0	0.006214	0	7	131										A	151152027	G	A	151152027	3	1	20	1	0	0	0	0	1	0	0	0	12068	1175	41	1	1834	1	PLEKHG1	6	151152027	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	12953767	151152027	19963040	165	5869										
SYNJ2	8871	broad.mit.edu	37	chr6	158516772	158516772	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtccctcctgttcccaaaccAagaacatttcagcctgggaa	7	14	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:158516772A>G	uc003qqx.1	+	27	3942	c.3867A>G	c.(3865-3867)CCA>CCG	p.P1289P	SYNJ2_uc003qqy.1_Silent_p.P1002P|SYNJ2_uc003qqz.1_Silent_p.P906P|SYNJ2_uc003qra.1_Silent_p.P632P|SYNJ2_uc010kjp.1_Silent_p.P172P	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1289	Catalytic (By similarity).|Pro-rich.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TTCCCAAACCAAGAACATTTC	0.597													0	0	0	0.008291	0	10	52										G	158516772	A	G	158516772	2	3	20	1	0	0	0	0	0	0	0	1	15450	117	5	5		5	SYNJ2	6	158516772	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	7364745	158516772	12598295	166	5870										
MAP3K4	4216	broad.mit.edu	37	chr6	161470322	161470322	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agattgtaggttactcaacaCatcatgagcatctccaacgc	7	11	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:161470322C>G	uc003qtn.2	+	3	1160	c.1018C>G	c.(1018-1020)CAT>GAT	p.H340D	MAP3K4_uc010kkc.1_Missense_Mutation_p.H340D|MAP3K4_uc003qto.2_Missense_Mutation_p.H340D|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	340					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TTACTCAACACATCATGAGCA	0.453													0	0	0	0.004482	0	7	73										G	161470322	C	G	161470322	3	3	20	1	0	0	0	0	1	0	0	0	9252	478	17	4	1028	4	MAP3K4	6	161470322	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2953550	161470322	9644745	167	5871										
MAP3K4	4216	broad.mit.edu	37	chr6	161470565	161470565	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgggcatcaagaatttatcaGacattggctggccagtgttt	11	7	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr6:161470565G>C	uc003qtn.2	+	3	1403	c.1261G>C	c.(1261-1263)GAC>CAC	p.D421H	MAP3K4_uc010kkc.1_Missense_Mutation_p.D421H|MAP3K4_uc003qto.2_Missense_Mutation_p.D421H|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	421					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GAATTTATCAGACATTGGCTG	0.438													0	0	0	0.006214	0	8	71										C	161470565	G	C	161470565	3	2	20	1	0	0	0	0	1	0	0	0	9252	942	33	1	1271	1	MAP3K4	6	161470565	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	243	161470565	9644502	168	5872										
SNX8	29886	broad.mit.edu	37	chr7	2311576	2311576	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgacgaagcgcttcagggctCtcctcctggcctcgatgaac	11	14	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:2311576C>G	uc003slw.2	-	4	492	c.449G>C	c.(448-450)AGA>ACA	p.R150T		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	150	PX.				cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CTTCAGGGCTCTCCTCCTGGC	0.637													0	0	0	0.009096	0	4	59										G	2311576	C	G	2311576	3	3	20	1	0	0	0	0	1	0	0	0	14908	913	32	1	980	1	SNX8	7	2311576	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		2311576	156827087	169	5873										
CREB5	9586	broad.mit.edu	37	chr7	28858795	28858795	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cccagcaacaagtcatccagCataataccatcactacttcc	3	16	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:28858795C>A	uc003szq.2	+	11	1816	c.1426C>A	c.(1426-1428)CAT>AAT	p.H476N	CREB5_uc003szo.2_Missense_Mutation_p.H443N|CREB5_uc003szr.2_Missense_Mutation_p.H469N|CREB5_uc003szs.2_Missense_Mutation_p.H337N	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	476					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AGTCATCCAGCATAATACCAT	0.502													1	0	9.64103e-21	0.01441	1.09667e-20	60	247										A	28858795	C	A	28858795	3	1	20	1	0	0	0	0	1	0	0	0	3860	710	25	4	1519	4	CREB5	7	28858795	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	26547219	28858795	130279868	170	5874										
ANLN	54443	broad.mit.edu	37	chr7	36445999	36445999	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tacaagaacagcctggtaccGcttgtttatccaaattttcc	6	11	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:36445999G>T	uc003tff.2	+	4	901	c.697G>T	c.(697-699)GCT>TCT	p.A233S	ANLN_uc011kaz.1_Missense_Mutation_p.A145S|ANLN_uc003tfg.2_Missense_Mutation_p.A233S|ANLN_uc010kxe.2_Missense_Mutation_p.A233S	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	233	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						GCCTGGTACCGCTTGTTTATC	0.458													1	0	4.7546e-09	0.004007	5.10223e-09	17	67										T	36445999	G	T	36445999	3	4	20	1	0	0	0	0	1	0	0	0	694	1087	38	4	711	4	ANLN	7	36445999	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	7587204	36445999	122692664	171	5875										
ELMO1	9844	broad.mit.edu	37	chr7	37311474	37311474	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaaggatagtgccattttttAtctcattgcggttctggaaa	10	6	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:37311474A>T	uc003tfk.1	-	5	513	c.206T>A	c.(205-207)ATA>AAA	p.I69K	ELMO1_uc011kbc.1_5'UTR|ELMO1_uc010kxg.1_Missense_Mutation_p.I69K	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	69					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GCCATTTTTTATCTCATTGCG	0.353													0	0	0	0.004482	0	6	107										T	37311474	A	T	37311474	3	4	20	1	0	0	0	0	1	0	0	0	5065	449	16	5	2049	5	ELMO1	7	37311474	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	865475	37311474	121827189	172	5876										
HUS1	3364	broad.mit.edu	37	chr7	48015279	48015279	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcaagactggtaaataaatActaacctacaaaaccaatga	4	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:48015279A>G	uc003tod.1	-	5	601	c.471T>C	c.(469-471)AGT>AGC	p.S157S	HUS1_uc003toe.1_Silent_p.S157S|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	157					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)				GTAAATAAATACTAACCTACA	0.318								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.00308	0	6	32										G	48015279	A	G	48015279	2	3	20	1	0	0	0	0	0	0	0	1	7459	388	14	5		5	HUS1	7	48015279	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	10703805	48015279	111123384	173	5877										
EGFR	1956	broad.mit.edu	37	chr7	55214318	55214318	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaaatcctgcatggcgccgtGcggttcagcaacaaccctgc	11	14	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:55214318G>A	uc003tqk.2	+	4	690	c.444G>A	c.(442-444)GTG>GTA	p.V148V	EGFR_uc003tqh.2_Silent_p.V148V|EGFR_uc003tqi.2_Silent_p.V148V|EGFR_uc003tqj.2_Silent_p.V148V|EGFR_uc010kzg.1_Intron|EGFR_uc011kco.1_Silent_p.V95V	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	148	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATGGCGCCGTGCGGTTCAGCA	0.532		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			0	0	0	0.006122	0	15	102										A	55214318	G	A	55214318	2	1	20	1	0	0	0	0	0	0	0	1	4967	1306	46	2		2	EGFR	7	55214318	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	7199039	55214318	103924345	174	5878										
POR	5447	broad.mit.edu	37	chr7	75615697	75615697	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gatgtgcagaacaccttctaCgacatcgtggctgagctcgg	12	11	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:75615697C>A	uc003udy.2	+	16	2023	c.1941C>A	c.(1939-1941)TAC>TAA	p.Y647*	POR_uc011kgc.1_Nonsense_Mutation_p.Y455*|POR_uc011kgd.1_Missense_Mutation_p.T553K|POR_uc011kge.1_Nonsense_Mutation_p.Y385*|POR_uc003uea.2_Nonsense_Mutation_p.Y134*	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	644					cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	ACACCTTCTACGACATCGTGG	0.632													1	0	1.55795e-14	0.012319	1.72894e-14	17	88										A	75615697	C	A	75615697	4	1	20	1	0	0	0	0	0	1	0	0	12257	547	19	4	1999	4	POR	7	75615697	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	20401379	75615697	83522966	175	5879										
RSBN1L	222194	broad.mit.edu	37	chr7	77326204	77326204	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgctgctgcacgctcagcctCaccatctcctcctgcccgcc	7	22	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:77326204C>T	uc010ldt.1	+	1	462	c.418C>T	c.(418-420)CAC>TAC	p.H140Y	RSBN1L_uc003ugm.2_5'Flank|uc003ugj.1_RNA	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	140						nucleus				ovary(1)	1						CGCTCAGCCTCACCATCTCCT	0.682													0	0	0	0.004482	0	6	51										T	77326204	C	T	77326204	3	4	20	1	0	0	0	0	1	0	0	0	13697	826	29	1	420	1	RSBN1L	7	77326204	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1710507	77326204	81812459	176	5880										
PCLO	27445	broad.mit.edu	37	chr7	82579040	82579040	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgagatgggtgagtaaaggaCtttgggggatttgggtgggg	21	1	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:82579040C>T	uc003uhx.2	-	6	11153	c.10864G>A	c.(10864-10866)GTC>ATC	p.V3622I	PCLO_uc003uhv.2_Missense_Mutation_p.V3622I|PCLO_uc010lec.2_Missense_Mutation_p.V587I	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3553					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAGTAAAGGACTTTGGGGGAT	0.478													0	0	0	0.006122	0	18	99										T	82579040	C	T	82579040	3	4	20	1	0	0	0	0	1	0	0	0	11583	565	20	2	4661	2	PCLO	7	82579040	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5252836	82579040	76559623	177	5881										
PCLO	27445	broad.mit.edu	37	chr7	82579271	82579271	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttaattatttctaccttggCatccactcgtgcccgtatgg	7	11	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:82579271C>T	uc003uhx.2	-	6	10922	c.10633G>A	c.(10633-10635)GCC>ACC	p.A3545T	PCLO_uc003uhv.2_Missense_Mutation_p.A3545T|PCLO_uc010lec.2_Missense_Mutation_p.A510T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3476					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCTACCTTGGCATCCACTCGT	0.443													0	0	0	0.004482	0	8	57										T	82579271	C	T	82579271	3	4	20	1	0	0	0	0	1	0	0	0	11583	710	25	2	4892	2	PCLO	7	82579271	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	231	82579271	76559392	178	5882										
CDK14	5218	broad.mit.edu	37	chr7	90528655	90528655	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcaccctggggggctgcatcCagataatgtgaaggtaggaa	15	8	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:90528655C>T	uc003uky.2	+	7	911	c.689C>T	c.(688-690)CCA>CTA	p.P230L	CDK14_uc003ukz.1_Missense_Mutation_p.P212L|CDK14_uc010les.1_Missense_Mutation_p.P184L|CDK14_uc011khl.1_Missense_Mutation_p.P101L	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	230	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						GGGCTGCATCCAGATAATGTG	0.363													0	0	0	0.00499	0	12	50										T	90528655	C	T	90528655	3	4	20	1	0	0	0	0	1	0	0	0	3130	594	21	2	657	2	CDK14	7	90528655	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	7949384	90528655	68610008	179	5883										
FZD1	8321	broad.mit.edu	37	chr7	90894816	90894816	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcatgaacaagttcggcttCcagtggccagacacgctcaa	9	13	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:90894816C>T	uc003ula.2	+	1	1034	c.621C>T	c.(619-621)TTC>TTT	p.F207F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	207	FZ.|Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			AGTTCGGCTTCCAGTGGCCAG	0.701													0	0	0	0.00499	0	15	75										T	90894816	C	T	90894816	2	4	20	1	0	0	0	0	0	0	0	1	6128	854	30	1		1	FZD1	7	90894816	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	366161	90894816	68243847	180	5884										
KRIT1	889	broad.mit.edu	37	chr7	91855114	91855114	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcttcacaaatatttaatgGagatcttccttgttggtctg	7	7	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:91855114G>C	uc003ulq.1	-	10	1345	c.1174C>G	c.(1174-1176)CCA>GCA	p.P392A	KRIT1_uc010lev.1_Intron|KRIT1_uc003ulr.1_Missense_Mutation_p.P392A|KRIT1_uc003uls.1_Missense_Mutation_p.P392A|KRIT1_uc003ult.1_Missense_Mutation_p.P344A|KRIT1_uc003ulu.1_Missense_Mutation_p.P392A|KRIT1_uc003ulv.1_Missense_Mutation_p.P392A	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	392	ANK 4.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATATTTAATGGAGATCTTCCT	0.348									Familial_Cerebral_Cavernous_Angioma				0	0	0	0.008291	0	11	87										C	91855114	G	C	91855114	3	2	20	1	0	0	0	0	1	0	0	0	8445	1174	41	1	1068	1	KRIT1	7	91855114	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	960298	91855114	67283549	181	5885										
GPC2	221914	broad.mit.edu	37	chr7	99771457	99771457	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggctttcttgaatcccctcaCccagatagttgccccagtca	7	15	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:99771457C>A	uc003utv.2	-	5	1060	c.892_splice	c.e5+1	p.D298_splice	GPC2_uc010lgr.2_Intron|GPC2_uc003utw.1_3'UTR	NM_152742	NP_689955	Q8N158	GPC2_HUMAN	glypican 2 precursor							anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|pancreas(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AATCCCCTCACCCAGATAGTT	0.378													1	0	3.13765e-25	0.01441	3.59605e-25	56	628										A	99771457	C	A	99771457	5	1	20	1	0	0	0	0	0	0	1	0	6598	521	18	4	870	4	GPC2	7	99771457	Splice_Site	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	7916343	99771457	59367206	182	5886										
CUX1	1523	broad.mit.edu	37	chr7	101882763	101882763	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaggaggcgctgaaacgagcGtatcagcaaaagccataccc	11	11	1	1	rs140169027		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:101882763G>T	uc003uyx.3	+	23	3824	c.3786G>T	c.(3784-3786)GCG>GCT	p.A1262A	CUX1_uc003uys.3_Silent_p.A1273A|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	1262	Homeobox.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						TGAAACGAGCGTATCAGCAAA	0.597													1	0	2.61193e-14	0.009535	2.88454e-14	28	87										T	101882763	G	T	101882763	2	4	20	1	0	0	0	0	0	0	0	1	4064	1132	40	4		4	CUX1	7	101882763	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2111306	101882763	57255900	183	5887										
LAMB4	22798	broad.mit.edu	37	chr7	107706844	107706844	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttctgccagttgtaaagcctCcacaattgaagcatgaccct	7	12	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:107706844C>A	uc010ljo.1	-	20	2732	c.2648G>T	c.(2647-2649)GGA>GTA	p.G883V	LAMB4_uc003vey.2_Missense_Mutation_p.G883V|LAMB4_uc010ljp.1_5'Flank	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	883	Laminin EGF-like 8.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGTAAAGCCTCCACAATTGAA	0.428													1	0	1.12685e-05	0.004482	1.17866e-05	7	49										A	107706844	C	A	107706844	3	1	20	1	0	0	0	0	1	0	0	0	8613	855	30	3	2697	3	LAMB4	7	107706844	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5824081	107706844	51431819	184	5888										
LMOD2	442721	broad.mit.edu	37	chr7	123302814	123302814	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctagctcttcaccttatgtaTctcccaggcactcaccctgg	6	16	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:123302814T>C	uc003vky.2	+	2	1331	c.1174T>C	c.(1174-1176)TCT>CCT	p.S392P		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	392	Pro-rich.					cytoskeleton	actin binding|tropomyosin binding				0						ACCTTATGTATCTCCCAGGCA	0.488													0	0	0	0.001855	0	13	90										C	123302814	T	C	123302814	3	2	20	1	0	0	0	0	1	0	0	0	8857	1435	50	5	1180	5	LMOD2	7	123302814	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	15595970	123302814	35835849	185	5889										
IRF5	3663	broad.mit.edu	37	chr7	128586051	128586051	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgccacctcagccctacaaGatctacgaggtctgctccaa	7	15	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:128586051G>C	uc003vog.2	+	3	469	c.348G>C	c.(346-348)AAG>AAC	p.K116N	IRF5_uc010llr.1_Missense_Mutation_p.K116N|IRF5_uc011kot.1_Missense_Mutation_p.K116N|IRF5_uc011kou.1_Missense_Mutation_p.K116N|IRF5_uc010lls.1_Missense_Mutation_p.K116N|IRF5_uc003voh.2_Missense_Mutation_p.K116N|IRF5_uc010llt.2_Missense_Mutation_p.K116N|IRF5_uc003voi.2_Missense_Mutation_p.K116N|IRF5_uc010llu.1_Missense_Mutation_p.K116N|IRF5_uc003vok.2_Missense_Mutation_p.K116N|IRF5_uc003voj.3_Missense_Mutation_p.K116N|IRF5_uc010llv.1_Missense_Mutation_p.K116N|IRF5_uc010llw.1_Missense_Mutation_p.K116N	NM_002200	NP_002191	Q13568	IRF5_HUMAN	interferon regulatory factor 5 isoform a	116	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGCCCTACAAGATCTACGAGG	0.637													0	0	0	0.004482	0	6	71										C	128586051	G	C	128586051	3	2	20	1	0	0	0	0	1	0	0	0	7833	933	33	1	354	1	IRF5	7	128586051	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	5283237	128586051	30552612	186	5890										
CPA2	1358	broad.mit.edu	37	chr7	129929559	129929559	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcttggcttgaaggcaatcaTggagcatgtgcgagaccacc	13	10	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:129929559T>C	uc003vpq.2	+	11	1251	c.1232T>C	c.(1231-1233)ATG>ACG	p.M411T		NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	411					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AAGGCAATCATGGAGCATGTG	0.522													0	0	0	0.012213	0	29	124										C	129929559	T	C	129929559	3	2	20	1	0	0	0	0	1	0	0	0	3790	1464	51	5	1274	5	CPA2	7	129929559	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	1343508	129929559	29209104	187	5891										
TMUB1	83590	broad.mit.edu	37	chr7	150779465	150779465	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcccctggggcctcccctctCatgctgtcggtagctgccat	11	17	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:150779465C>A	uc003wjb.2	-	1	301	c.186G>T	c.(184-186)ATG>ATT	p.M62I	FASTK_uc003wiw.1_5'Flank|FASTK_uc003wix.1_5'Flank|FASTK_uc003wiy.1_5'Flank|FASTK_uc003wiz.1_5'Flank|FASTK_uc003wja.1_5'Flank|TMUB1_uc003wjc.2_Missense_Mutation_p.M62I|TMUB1_uc003wjd.2_Missense_Mutation_p.M62I	NM_031434	NP_113622	Q9BVT8	TMUB1_HUMAN	transmembrane and ubiquitin-like domain	62						cytoplasm|integral to membrane|nucleus					0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCCCTCTCATGCTGTCGG	0.687													1	0	3.7963e-18	0.00333	4.26498e-18	20	134										A	150779465	C	A	150779465	3	1	20	1	0	0	0	0	1	0	0	0	16261	826	29	3	562	3	TMUB1	7	150779465	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	20849906	150779465	8359198	188	5892										
MLL3	58508	broad.mit.edu	37	chr7	151919766	151919766	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctgacaaactgcatgcatccAtctaaaaagaccatatttgt	5	10	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr7:151919766A>G	uc003wla.2	-	21	3544	c.3325T>C	c.(3325-3327)TGG>CGG	p.W1109R	MLL3_uc003wkz.2_Missense_Mutation_p.W170R	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1109	PHD-type 6.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCATGCATCCATCTAAAAAGA	0.348			N		medulloblastoma								0	0	0	0.001984	0	6	33										G	151919766	A	G	151919766	3	3	20	1	0	0	0	0	1	0	0	0	9622	231	8	5	11566	5	MLL3	7	151919766	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	1140301	151919766	7218897	189	5893										
RP1L1	94137	broad.mit.edu	37	chr8	10466033	10466033	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cccttcagcctcctgggcatCcccttctgcctctggggcct	9	19	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr8:10466033C>T	uc003wtc.2	-	4	5804	c.5575G>A	c.(5575-5577)GAT>AAT	p.D1859N		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1859					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCTGGGCATCCCCTTCTGCC	0.627													0	0	0	0.006122	0	14	323										T	10466033	C	T	10466033	3	4	20	1	0	0	0	0	1	0	0	0	13533	855	30	1	1631	1	RP1L1	8	10466033	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		10466033	135897989	190	5894										
SDR16C5	195814	broad.mit.edu	37	chr8	57228822	57228822	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccgtggctttgggagtaaggCaaaaatcatagcctccagaa	11	9	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr8:57228822C>T	uc003xsy.1	-	2	723	c.85G>A	c.(85-87)GCC>ACC	p.A29T	SDR16C5_uc010lyk.1_Missense_Mutation_p.A29T|SDR16C5_uc010lyl.1_Missense_Mutation_p.A29T	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	29	Helical; (Potential).				detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GGGAGTAAGGCAAAAATCATA	0.458													0	0	0	0.003954	0	19	65										T	57228822	C	T	57228822	3	4	20	1	0	0	0	0	1	0	0	0	13971	710	25	2	868	2	SDR16C5	8	57228822	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	46762789	57228822	89135200	191	5895										
MTDH	92140	broad.mit.edu	37	chr8	98703239	98703239	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaggctggaatgaaaagtctGtaaaactctcctcacagatc	9	9	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr8:98703239G>C	uc003yhz.2	+	6	1199	c.871G>C	c.(871-873)GTA>CTA	p.V291L	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	291	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TGAAAAGTCTGTAAAACTCTC	0.418													0	0	0	0.00308	0	6	60										C	98703239	G	C	98703239	3	2	20	1	0	0	0	0	1	0	0	0	9917	1377	48	4	893	4	MTDH	8	98703239	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	41474417	98703239	47660783	192	5896										
ZNF250	58500	broad.mit.edu	37	chr8	146108216	146108216	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgactctctcccttggtttCacattctgaaagaacaaatc	5	11	3	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr8:146108216C>T	uc003zeq.3	-	6	484	c.367G>A	c.(367-369)GAA>AAA	p.E123K	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.E118K|ZNF250_uc010mgg.2_Missense_Mutation_p.E118K	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		CCCTTGGTTTCACATTCTGAA	0.413													0	0	0	0.001855	0	11	167										T	146108216	C	T	146108216	3	4	20	1	0	0	0	0	1	0	0	0	17792	835	29	1	1319	1	ZNF250	8	146108216	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	47404977	146108216	255806	193	5897										
VPS13A	23230	broad.mit.edu	37	chr9	79960014	79960014	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gatggagcagctacattcctCttaataaatcacacaaagaa	6	9	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:79960014C>G	uc004akr.2	+	52	7505	c.7245C>G	c.(7243-7245)CTC>CTG	p.L2415L	VPS13A_uc004akp.3_Silent_p.L2415L|VPS13A_uc004akq.3_Silent_p.L2415L|VPS13A_uc004aks.2_Silent_p.L2376L	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2415					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CTACATTCCTCTTAATAAATC	0.343													0	0	0	0.004007	0	14	131										G	79960014	C	G	79960014	2	3	20	1	0	0	0	0	0	0	0	1	17186	900	32	1		1	VPS13A	9	79960014	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		79960014	61253417	194	5898										
C9orf102	375748	broad.mit.edu	37	chr9	98691012	98691012	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcgtctagttgcttgacgtGctacagcagtactgtatggc	11	10	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:98691012G>A	uc004avt.3	+	11	2038	c.1650G>A	c.(1648-1650)GTG>GTA	p.V550V	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Silent_p.V252V|C9orf102_uc010mry.1_Silent_p.V252V|C9orf102_uc010mrz.2_Silent_p.V361V|C9orf102_uc004avu.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	550	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				TGCTTGACGTGCTACAGCAGT	0.393													0	0	0	0.007291	0	22	103										A	98691012	G	A	98691012	2	1	20	1	0	0	0	0	0	0	0	1	2445	1306	46	2		2	C9orf102	9	98691012	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	18730998	98691012	42522419	195	5899										
C9orf156	51531	broad.mit.edu	37	chr9	100667070	100667070	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagtcatatgaacaggctcaGaagccggcttgatcctcagc	10	12	3	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:100667070G>A	uc004axv.1	-	5	1348	c.1271C>T	c.(1270-1272)TCT>TTT	p.S424F	C9orf156_uc004axw.1_Missense_Mutation_p.S321F|C9orf156_uc004axx.1_Missense_Mutation_p.S278F	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	424					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				AACAGGCTCAGAAGCCGGCTT	0.502													0	0	0	0.00245	0	14	109										A	100667070	G	A	100667070	3	1	20	1	0	0	0	0	1	0	0	0	2465	942	33	1	58	1	C9orf156	9	100667070	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1976058	100667070	40546361	196	5900										
PTPN3	5774	broad.mit.edu	37	chr9	112151539	112151539	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcgttctgtgagagtcgtcaAcatgacaatgagtgacaact	10	8	2	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:112151539A>G	uc004bed.2	-	22	2339	c.2227T>C	c.(2227-2229)TTG>CTG	p.L743L	PTPN3_uc004beb.2_Silent_p.L612L|PTPN3_uc004bec.2_Silent_p.L567L|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.L698L|PTPN3_uc011lwh.1_Silent_p.L589L|PTPN3_uc011lwd.1_Silent_p.L211L|PTPN3_uc011lwe.1_Silent_p.L456L|PTPN3_uc011lwf.1_Silent_p.L411L	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	743	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AGAGTCGTCAACATGACAATG	0.502													0	0	0	0.010729	0	9	74										G	112151539	A	G	112151539	2	3	20	1	0	0	0	0	0	0	0	1	12789	40	2	5		5	PTPN3	9	112151539	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	11484469	112151539	29061892	197	5901										
PTPN3	5774	broad.mit.edu	37	chr9	112189306	112189306	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggtagtagcttctttgcctGaaagaacgtatggtgctcaa	11	7	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:112189306G>A	uc004bed.2	-	12	1037	c.925C>T	c.(925-927)CAG>TAG	p.Q309*	PTPN3_uc004beb.2_Nonsense_Mutation_p.Q178*|PTPN3_uc004bec.2_Nonsense_Mutation_p.Q178*|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Nonsense_Mutation_p.Q309*|PTPN3_uc011lwh.1_Nonsense_Mutation_p.Q200*|PTPN3_uc011lwe.1_Nonsense_Mutation_p.Q22*|PTPN3_uc011lwf.1_Nonsense_Mutation_p.Q22*	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	309	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						TTCTTTGCCTGAAAGAACGTA	0.448													0	0	0	0.001984	0	6	104										A	112189306	G	A	112189306	4	1	20	1	0	0	0	0	0	1	0	0	12789	1299	45	1	1876	1	PTPN3	9	112189306	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	37767	112189306	29024125	198	5902										
OR1L1	26737	broad.mit.edu	37	chr9	125424441	125424441	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctgcttctggttctctccttCtgcattccacattttcactc	4	15	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:125424441C>A	uc011lza.1	+	1	597	c.597C>A	c.(595-597)TTC>TTA	p.F199L		NM_001005236	NP_001005236	Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L,	199	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TTCTCTCCTTCTGCATTCCAC	0.463													1	0	6.4685e-43	0.01441	7.45105e-43	51	373										A	125424441	C	A	125424441	3	1	20	1	0	0	0	0	1	0	0	0	10963	912	32	3	449	3	OR1L1	9	125424441	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	13235135	125424441	15788990	199	5903										
FUBP3	8939	broad.mit.edu	37	chr9	133506081	133506081	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggagcttcagaggaacccccCtcccaacagcgaccccaacc	8	19	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:133506081C>T	uc004bzr.1	+	13	1292	c.1184C>T	c.(1183-1185)CCT>CTT	p.P395L	FUBP3_uc004bzs.1_Missense_Mutation_p.P308L	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	395	KH 4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		AGGAACCCCCCTCCCAACAGC	0.587													0	0	0	0.000602	0	5	84										T	133506081	C	T	133506081	3	4	20	1	0	0	0	0	1	0	0	0	6093	681	24	2	1234	2	FUBP3	9	133506081	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	8081640	133506081	7707350	200	5904										
SURF6	6838	broad.mit.edu	37	chr9	136201230	136201234	+	Frame_Shift_Del	DEL	GCAGG	GCAGG	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgccctgaagcctctcacctGcagggttccctgctgagctg					rs35975060		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:136201230_136201234delGCAGG	uc004cdb.3	-	2	376_380	c.298_302delCCTGC	c.(298-303)CCTGCAfs	p.P100fs		NM_006753	NP_006744	O75683	SURF6_HUMAN	surfeit 6	100_101						granular component	DNA binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		CCTCTCACCTGCAGGGTTCCCTGCT	0.605																		7	50	---	---								-	136201234	GCAGG	-	136201230	7	5	20	1	0	1	0	1	0	0	0	0	15403	1319	46	0	799	0	SURF6	9	136201230	Frame_Shift_Del	DEL	GCAGG	TCGA-BT-A3PK-01A-21D-A21Z-08	2695149	136201230	5012201	201	5905										
SURF1	6834	broad.mit.edu	37	chr9	136220674	136220682	+	In_Frame_Del	DEL	CCTCCCGGG	CCTCCCGGG	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaggaggagatgaggccgcCctcccgggcctcccggacag					rs151258319		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:136220674_136220682delCCTCCCGGG	uc004cdh.1	-	5	469_477	c.437_445delCCCGGGAGG	c.(436-447)GCCCGGGAGGGC>GGC	p.ARE146del	SURF1_uc004cdg.1_In_Frame_Del_p.ARE37del|SURF2_uc004cdi.2_5'Flank	NM_003172	NP_003163	Q15526	SURF1_HUMAN	surfeit 1	146_148					aerobic respiration|respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			breast(2)	2				OV - Ovarian serous cystadenocarcinoma(145;5.06e-07)|Epithelial(140;4.25e-06)|all cancers(34;3.93e-05)		ATGAGGCCGCCCTCCCGGGCCTCCCGGAC	0.598																		33	331	---	---								-	136220682	CCTCCCGGG	-	136220674	7	5	20	1	0	1	0	1	0	0	0	0	15400	623	22	0	477	0	SURF1	9	136220674	In_Frame_Del	DEL	CCTCCCGGG	TCGA-BT-A3PK-01A-21D-A21Z-08	19444	136220674	4992757	202	5906										
SLC2A6	11182	broad.mit.edu	37	chr9	136337170	136337170	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aagaaggaccttctccccgtGcggaagaaggactcgatctg	12	11	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:136337170G>A	uc004cee.2	-	10	1592	c.1497C>T	c.(1495-1497)CGC>CGT	p.R499R	SLC2A6_uc004cef.2_Silent_p.R437R|SLC2A6_uc004ceg.2_Silent_p.R476R	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	499	Cytoplasmic (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		TTCTCCCCGTGCGGAAGAAGG	0.627													0	0	0	0.001855	0	13	63										A	136337170	G	A	136337170	2	1	20	1	0	0	0	0	0	0	0	1	14549	1306	46	2		2	SLC2A6	9	136337170	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	116496	136337170	4876261	203	5907										
PMPCA	23203	broad.mit.edu	37	chr9	139306631	139306631	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggcatctcagaataagtttgGacagttttgtacagtaggaa	11	5	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr9:139306631G>C	uc004chl.2	+	2	259	c.254G>C	c.(253-255)GGA>GCA	p.G85A	SDCCAG3_uc004chi.2_5'Flank|SDCCAG3_uc004chj.2_5'Flank|SDCCAG3_uc004chk.2_5'Flank|PMPCA_uc011mdy.1_Missense_Mutation_p.G85A|PMPCA_uc010nbk.2_RNA|PMPCA_uc010nbl.2_5'UTR|PMPCA_uc011mdz.1_5'UTR	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	85					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		AATAAGTTTGGACAGTTTTGT	0.423													0	0	0	0.004007	0	10	277										C	139306631	G	C	139306631	3	2	20	1	0	0	0	0	1	0	0	0	12140	1174	41	1	260	1	PMPCA	9	139306631	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2969461	139306631	1906800	204	5908										
SLC39A12	221074	broad.mit.edu	37	chr10	18289692	18289692	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggagcagccttctcatcatCatccgagtcaggagtgacca	10	12	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:18289692C>T	uc001ipo.2	+	11	1970	c.1697C>T	c.(1696-1698)TCA>TTA	p.S566L	SLC39A12_uc001ipn.2_Missense_Mutation_p.S529L|SLC39A12_uc001ipp.2_Missense_Mutation_p.S565L|SLC39A12_uc010qck.1_Missense_Mutation_p.S432L	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	566	Poly-Ser.|Cytoplasmic (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TTCTCATCATCATCCGAGTCA	0.443													0	0	0	0.000602	0	5	75										T	18289692	C	T	18289692	3	4	20	1	0	0	0	0	1	0	0	0	14615	838	29	1	1735	1	SLC39A12	10	18289692	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		18289692	117245055	205	5909										
KIAA1217	56243	broad.mit.edu	37	chr10	24822144	24822144	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggaagaagaagaagaaggagAcaaaataatggcagaactcc	12	5	0	6			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:24822144A>G	uc001iru.3	+	16	3795	c.3392A>G	c.(3391-3393)GAC>GGC	p.D1131G	KIAA1217_uc001irs.2_Missense_Mutation_p.D1051G|KIAA1217_uc001irt.3_Missense_Mutation_p.D1096G|KIAA1217_uc010qcy.1_Missense_Mutation_p.D1095G|KIAA1217_uc010qcz.1_Missense_Mutation_p.D1096G|KIAA1217_uc001irw.2_Missense_Mutation_p.D814G|KIAA1217_uc001irz.2_Missense_Mutation_p.D814G|KIAA1217_uc001irx.2_Missense_Mutation_p.D814G|KIAA1217_uc001iry.2_Missense_Mutation_p.D814G	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1131					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GAAGAAGGAGACAAAATAATG	0.537													0	0	0	0.010729	0	9	72										G	24822144	A	G	24822144	3	3	20	1	0	0	0	0	1	0	0	0	8216	275	10	5	3454	5	KIAA1217	10	24822144	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	6532452	24822144	110712603	206	5910										
PTCHD3	374308	broad.mit.edu	37	chr10	27703135	27703135	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tccggtttggtgagcttgggCttctgctccggccccggcct	14	14	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:27703135C>T	uc001itu.2	-	1	163	c.45G>A	c.(43-45)AAG>AAA	p.K15K		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	15					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGAGCTTGGGCTTCTGCTCCG	0.642													0	0	0	0.007835	0	36	188										T	27703135	C	T	27703135	2	4	20	1	0	0	0	0	0	0	0	1	12734	796	28	2		2	PTCHD3	10	27703135	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2880991	27703135	107831612	207	5911										
TMEM72	643236	broad.mit.edu	37	chr10	45430459	45430459	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtccgcatagtcccctccctCgccgaaggtctggatgatgg	12	14	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:45430459C>T	uc001jbn.2	+	5	902	c.705C>T	c.(703-705)CTC>CTT	p.L235L	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Silent_p.L117L	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	235						integral to membrane					0						TCCCCTCCCTCGCCGAAGGTC	0.602													0	0	0	0.008291	0	9	176										T	45430459	C	T	45430459	2	4	20	1	0	0	0	0	0	0	0	1	16198	871	31	1		1	TMEM72	10	45430459	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	17727324	45430459	90104288	208	5912										
OGDHL	55753	broad.mit.edu	37	chr10	50957813	50957813	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggggtcaaactggcagaagaTctgctccaggtccttgcgga	14	10	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:50957813T>A	uc001jie.2	-	8	1088	c.946A>T	c.(946-948)ATC>TTC	p.I316F	OGDHL_uc009xog.2_Missense_Mutation_p.I343F|OGDHL_uc010qgt.1_Missense_Mutation_p.I259F|OGDHL_uc010qgu.1_Missense_Mutation_p.I107F|OGDHL_uc009xoh.2_Missense_Mutation_p.I107F	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	316					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TGGCAGAAGATCTGCTCCAGG	0.662													0	0	0	0.000602	0	4	26										A	50957813	T	A	50957813	3	1	20	1	0	0	0	0	1	0	0	0	10840	1435	50	5	2150	5	OGDHL	10	50957813	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	5527354	50957813	84576934	209	5913										
ARID5B	84159	broad.mit.edu	37	chr10	63850916	63850916	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggccagcaaacagccactcaCctctcctagtgccctggtgg	10	16	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:63850916C>T	uc001jlt.1	+	10	1720	c.1694C>T	c.(1693-1695)ACC>ATC	p.T565I		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	565					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CAGCCACTCACCTCTCCTAGT	0.562													0	0	0	0.004007	0	14	62										T	63850916	C	T	63850916	3	4	20	1	0	0	0	0	1	0	0	0	922	507	18	2	1732	2	ARID5B	10	63850916	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	12893103	63850916	71683831	210	5914										
EGR2	1959	broad.mit.edu	37	chr10	64573654	64573654	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtgtccagtgggcagggaaaGggcttacggtctgggccagc	18	9	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:64573654G>C	uc010qim.1	-	3	898	c.744C>G	c.(742-744)CCC>CCG	p.P248P	EGR2_uc010qin.1_Silent_p.P198P|EGR2_uc001jmi.2_Silent_p.P248P|EGR2_uc010qio.1_Silent_p.P261P|EGR2_uc009xph.2_Silent_p.P248P	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	248					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGCAGGGAAAGGGCTTACGGT	0.597													0	0	0	0.007413	0	16	95										C	64573654	G	C	64573654	2	2	20	1	0	0	0	0	0	0	0	1	4972	987	35	4		4	EGR2	10	64573654	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	722738	64573654	70961093	211	5915										
EGR2	1959	broad.mit.edu	37	chr10	64575748	64575748	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agctggtgcacaaaaccactGagagttactgggattttgtc	11	8	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:64575748G>A	uc010qim.1	-	2	196	c.42C>T	c.(40-42)CTC>CTT	p.L14L	EGR2_uc010qin.1_Intron|EGR2_uc001jmi.2_Silent_p.L14L|EGR2_uc010qio.1_Intron|EGR2_uc009xph.2_Silent_p.L14L	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	14					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CAAAACCACTGAGAGTTACTG	0.572													0	0	0	0.00632	0	21	369										A	64575748	G	A	64575748	2	1	20	1	0	0	0	0	0	0	0	1	4972	1277	45	1		1	EGR2	10	64575748	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2094	64575748	70958999	212	5916										
REEP3	221035	broad.mit.edu	37	chr10	65369972	65369972	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggagcaataactgaacgttTaagaagcttcagtatgcatg	10	6	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:65369972T>G	uc001jmt.2	+	6	626	c.443T>G	c.(442-444)TTA>TGA	p.L148*		NM_001001330	NP_001001330	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	148						integral to membrane					0	Prostate(12;0.0119)|all_hematologic(501;0.191)					ACTGAACGTTTAAGAAGCTTC	0.328													0	0	0	0.004672	0	3	10										G	65369972	T	G	65369972	4	3	20	1	0	0	0	0	0	1	0	0	13206	1764	61	5	465	5	REEP3	10	65369972	Nonsense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	794224	65369972	70164775	213	5917										
DNA2	1763	broad.mit.edu	37	chr10	70182518	70182518	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccccactaacacaaatctccGtgaaaaaaaaagggggccca	7	13	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:70182518G>A	uc001jof.2	-	15	2596	c.2596C>T	c.(2596-2598)CGG>TGG	p.R866W	DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	780					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						ACAAATCTCCGTGAAAAAAAA	0.408													0	0	0	0.00308	0	8	22										A	70182518	G	A	70182518	3	1	20	1	0	0	0	0	1	0	0	0	4596	1144	40	2	872	2	DNA2	10	70182518	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4812546	70182518	65352229	214	5918										
SYNPO2L	79933	broad.mit.edu	37	chr10	75407279	75407279	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catagggggcggggtcttggGagccattggagggggggtct	22	6	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:75407279G>C	uc001jut.3	-	4	2283	c.2131C>G	c.(2131-2133)CCC>GCC	p.P711A	SYNPO2L_uc001jus.3_Missense_Mutation_p.P487A	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	711	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					GGGGTCTTGGGAGCCATTGGA	0.627													0	0	0	0.006999	0	31	133										C	75407279	G	C	75407279	3	2	20	1	0	0	0	0	1	0	0	0	15455	1174	41	1	806	1	SYNPO2L	10	75407279	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	5224761	75407279	60127468	215	5919										
GRID1	2894	broad.mit.edu	37	chr10	87362131	87362131	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggtcttcaccgggctctgccGgaacagccccccgttgggtg	14	15	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:87362131G>A	uc001kdl.1	-	16	3030	c.2929C>T	c.(2929-2931)CGG>TGG	p.R977W	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.R548W|uc001kdk.1_Intron	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	977	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	GGGCTCTGCCGGAACAGCCCC	0.667										Multiple Myeloma(13;0.14)			0	0	0	0.003954	0	21	96										A	87362131	G	A	87362131	3	1	20	1	0	0	0	0	1	0	0	0	6771	1115	39	2	104	2	GRID1	10	87362131	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	11954852	87362131	48172616	216	5920										
HMX3	340784	broad.mit.edu	37	chr10	124895626	124895627	+	Frame_Shift_Ins	INS	-	-	C													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cacagccccaaccgccgccgINSccccccccacccgctcccaa							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr10:124895626_124895627insC	uc010quc.1	+	1	60_61	c.60_61insC	c.(58-63)CCGCCCfs	p.P20fs		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	20_21	Pro-rich.				cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		AACCGCCGCCGCCCCCCCCACC	0.748																		2	4	---	---								C	124895627	-	C	124895626	7	5	20	1	0	1	1	0	0	0	0	0	7248	1074	38	0	62	0	HMX3	10	124895626	Frame_Shift_Ins	INS	-	TCGA-BT-A3PK-01A-21D-A21Z-08	37533495	124895626	10639121	217	5921										
NUP98	4928	broad.mit.edu	37	chr11	3746382	3746382	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaagctagattttctgaatCacgattaacaggagaaaaga	9	5	2	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:3746382C>T	uc001lyh.2	-	15	2089	c.1798G>A	c.(1798-1800)GAT>AAT	p.D600N	NUP98_uc001lyi.2_Missense_Mutation_p.D600N|NUP98_uc001lyj.1_Missense_Mutation_p.D600N|NUP98_uc001lyk.1_Missense_Mutation_p.D617N	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	617					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TTTTCTGAATCACGATTAACA	0.328			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.00308	0	7	57										T	3746382	C	T	3746382	3	4	20	1	0	0	0	0	1	0	0	0	10773	826	29	1	3701	1	NUP98	11	3746382	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		3746382	131260134	218	5922										
OR52K2	119774	broad.mit.edu	37	chr11	4470668	4470668	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atctggatctccatccctttCtgcttagcatatacactggc	6	13	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:4470668C>G	uc001lyz.1	+	1	99	c.99C>G	c.(97-99)TTC>TTG	p.F33L		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATCCCTTTCTGCTTAGCAT	0.517													0	0	0	0.010504	0	18	112										G	4470668	C	G	4470668	3	3	20	1	0	0	0	0	1	0	0	0	11124	912	32	1	101	1	OR52K2	11	4470668	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	724286	4470668	130535848	219	5923										
TEAD1	7003	broad.mit.edu	37	chr11	12901332	12901332	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atcgtctcggccactgccatTcataacaagctggggctgcc	10	14	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:12901332T>A	uc001mkj.3	+	6	1028	c.363T>A	c.(361-363)ATT>ATA	p.I121I	TEAD1_uc001mkk.3_Silent_p.I40I|TEAD1_uc009ygl.2_Silent_p.I15I	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	136					hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCACTGCCATTCATAACAAGC	0.597													0	0	0	0.001168	0	5	106										A	12901332	T	A	12901332	2	1	20	1	0	0	0	0	0	0	0	1	15735	1771	62	5		5	TEAD1	11	12901332	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	8430664	12901332	122105184	220	5924										
ACCSL	390110	broad.mit.edu	37	chr11	44075044	44075044	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcactgatgaaatacctggAatttgccaagaggtatgagt	10	7	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:44075044A>C	uc001mxw.1	+	8	1093	c.1037A>C	c.(1036-1038)GAA>GCA	p.E346A	ACCSL_uc009ykr.2_Missense_Mutation_p.E165A	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	346							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5						AAATACCTGGAATTTGCCAAG	0.433													0	0	0	0.008291	0	8	63										C	44075044	A	C	44075044	3	2	20	1	0	0	0	0	1	0	0	0	134	246	9	5	1067	5	ACCSL	11	44075044	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	31173712	44075044	90931472	221	5925										
DGKZ	8525	broad.mit.edu	37	chr11	46397494	46397494	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tacgacaaggagcagctcaaGgaggcctgtgagtgcggtgg	17	8	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:46397494G>T	uc001ncn.1	+	22	2693	c.2568G>T	c.(2566-2568)AAG>AAT	p.K856N	DGKZ_uc001nch.1_Missense_Mutation_p.K684N|DGKZ_uc010rgq.1_Missense_Mutation_p.K611N|DGKZ_uc001ncj.1_Missense_Mutation_p.K634N|DGKZ_uc010rgr.1_Missense_Mutation_p.K633N|DGKZ_uc001nck.1_Missense_Mutation_p.K446N|DGKZ_uc001ncl.2_Missense_Mutation_p.K668N|DGKZ_uc001ncm.2_Missense_Mutation_p.K667N|DGKZ_uc009yky.1_Missense_Mutation_p.K668N|DGKZ_uc010rgs.1_Missense_Mutation_p.K645N	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	856					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		AGCAGCTCAAGGAGGCCTGTG	0.687													1	0	0.004672	0.004672	0.00475562	3	16										T	46397494	G	T	46397494	3	4	20	1	0	0	0	0	1	0	0	0	4474	991	35	4	3097	4	DGKZ	11	46397494	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2322450	46397494	88609022	222	5926										
OR8H2	390151	broad.mit.edu	37	chr11	55872742	55872742	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atttattgacctcagttactCaactgtcgtcacacctaaaa	4	11	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:55872742C>G	uc010riy.1	+	1	224	c.224C>G	c.(223-225)TCA>TGA	p.S75*		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CTCAGTTACTCAACTGTCGTC	0.438										HNSCC(53;0.14)			0	0	0	0.004656	0	22	485										G	55872742	C	G	55872742	4	3	20	1	0	0	0	0	0	1	0	0	11238	838	29	1	226	1	OR8H2	11	55872742	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	9475248	55872742	79133774	223	5927										
OR8H2	390151	broad.mit.edu	37	chr11	55873336	55873336	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttccttgggaagagatcaagTggcttctgttttttatacta	9	6	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:55873336T>C	uc010riy.1	+	1	818	c.818T>C	c.(817-819)GTG>GCG	p.V273A		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					AGAGATCAAGTGGCTTCTGTT	0.373										HNSCC(53;0.14)			0	0	0	0.007413	0	16	96										C	55873336	T	C	55873336	3	2	20	1	0	0	0	0	1	0	0	0	11238	1696	59	5	820	5	OR8H2	11	55873336	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	594	55873336	79133180	224	5928										
OR10Q1	219960	broad.mit.edu	37	chr11	57995840	57995840	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtggtggccgcaaaagggcaGggtgaagattaaggcggtga	19	5	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:57995840G>T	uc010rkd.1	-	1	508	c.508C>A	c.(508-510)CTG>ATG	p.L170M		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				CAAAAGGGCAGGGTGAAGATT	0.652													1	0	0.000602214	0.000602	0.000615747	5	48										T	57995840	G	T	57995840	3	4	20	1	0	0	0	0	1	0	0	0	10916	991	35	4	455	4	OR10Q1	11	57995840	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2122504	57995840	77010676	225	5929										
AHNAK	79026	broad.mit.edu	37	chr11	62291760	62291760	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggacctgttatgtcaatatCtggctttttacctttgacat	7	8	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62291760C>G	uc001ntl.2	-	5	10429	c.10129G>C	c.(10129-10131)GAT>CAT	p.D3377H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3377					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGTCAATATCTGGCTTTTTA	0.383													0	0	0	0.006214	0	8	95										G	62291760	C	G	62291760	3	3	20	1	0	0	0	0	1	0	0	0	414	913	32	1	7663	1	AHNAK	11	62291760	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	4295920	62291760	72714756	226	5930			1	18		5	5	2419	C		4.428981e-08
AHNAK	79026	broad.mit.edu	37	chr11	62292043	62292043	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttacatgcatgtcaggcatCttcagttttggaccttttaa	7	8	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62292043C>G	uc001ntl.2	-	5	10146	c.9846G>C	c.(9844-9846)AAG>AAC	p.K3282N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3282					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGTCAGGCATCTTCAGTTTTG	0.428													0	0	0	0.006214	0	6	121										G	62292043	C	G	62292043	3	3	20	1	0	0	0	0	1	0	0	0	414	912	32	1	7946	1	AHNAK	11	62292043	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	283	62292043	72714473	227	5931			1	18		5	5	2419	C		4.428981e-08
AHNAK	79026	broad.mit.edu	37	chr11	62292768	62292768	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggcaggttcacatccacatCtgggccctctcctttgaagc	10	14	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62292768C>G	uc001ntl.2	-	5	9421	c.9121G>C	c.(9121-9123)GAT>CAT	p.D3041H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3041					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACATCCACATCTGGGCCCTCT	0.522													0	0	0	0.004289	0	28	401										G	62292768	C	G	62292768	3	3	20	1	0	0	0	0	1	0	0	0	414	913	32	1	8671	1	AHNAK	11	62292768	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	725	62292768	72713748	228	5932			1	18		5	5	2419	C		4.428981e-08
AHNAK	79026	broad.mit.edu	37	chr11	62292797	62292797	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcctttgaagccaggcatgCtgaatttgggcattttcact	9	10	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62292797C>G	uc001ntl.2	-	5	9392	c.9092G>C	c.(9091-9093)AGC>ACC	p.S3031T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3031					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GCCAGGCATGCTGAATTTGGG	0.532													0	0	0	0.005524	0	30	424										G	62292797	C	G	62292797	3	3	20	1	0	0	0	0	1	0	0	0	414	797	28	4	8700	4	AHNAK	11	62292797	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	29	62292797	72713719	229	5933			1	18		5	5	2419	C		4.428981e-08
AHNAK	79026	broad.mit.edu	37	chr11	62294178	62294178	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggggctttgatgttcatctCtggcatctttaacttaggcc	11	9	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62294178C>G	uc001ntl.2	-	5	8011	c.7711G>C	c.(7711-7713)GAG>CAG	p.E2571Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2571					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGTTCATCTCTGGCATCTTT	0.473													0	0	0	0.00333	0	19	260										G	62294178	C	G	62294178	3	3	20	1	0	0	0	0	1	0	0	0	414	922	32	1	10081	1	AHNAK	11	62294178	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1381	62294178	72712338	230	5934			1	18		5	5	2419	C		4.428981e-08
METTL12	751071	broad.mit.edu	37	chr11	62434192	62434192	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggccaaacacctctatgccCtggacaccctgcctcaagcc	7	18	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62434192C>T	uc001nug.1	+	3	651	c.392C>T	c.(391-393)CCT>CTT	p.P131L	C11orf48_uc001nue.2_Intron|C11orf48_uc001nuf.2_Intron|METTL12_uc001nuh.2_3'UTR|METTL12_uc010rmc.1_RNA	NM_001043229	NP_001036694	A8MUP2	MTL12_HUMAN	methyltransferase like 12 precursor	131						mitochondrion	methyltransferase activity				0						CCTCTATGCCCTGGACACCCT	0.597													0	0	0	0.008291	0	11	61										T	62434192	C	T	62434192	3	4	20	1	0	0	0	0	1	0	0	0	9496	681	24	2	398	2	METTL12	11	62434192	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	140014	62434192	72572324	231	5935										
ZBTB3	79842	broad.mit.edu	37	chr11	62521022	62521022	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcaggaggccagcacagcccGatgggccaagaactgggtac	15	12	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:62521022G>C	uc001nuz.2	-	2	387	c.265C>G	c.(265-267)CGG>GGG	p.R89G		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	89	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						AGCACAGCCCGATGGGCCAAG	0.557													0	0	0	0.009096	0	4	26										C	62521022	G	C	62521022	3	2	20	1	0	0	0	0	1	0	0	0	17531	1057	37	1	1463	1	ZBTB3	11	62521022	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	86830	62521022	72485494	232	5936										
SLC29A2	3177	broad.mit.edu	37	chr11	66133943	66133943	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaaggttttcctggcttctGgggctcatctggctctgatt	12	9	4	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:66133943G>C	uc001oht.2	-	8	1055	c.826C>G	c.(826-828)CAG>GAG	p.Q276E	SLC29A2_uc001ohs.2_Missense_Mutation_p.Q156E|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Missense_Mutation_p.Q156E|SLC29A2_uc001ohu.2_Missense_Mutation_p.Q276E|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	276					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						CCTGGCTTCTGGGGCTCATCT	0.532													0	0	0	0.010729	0	10	56										C	66133943	G	C	66133943	3	2	20	1	0	0	0	0	1	0	0	0	14535	1357	47	4	564	4	SLC29A2	11	66133943	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3612921	66133943	68872573	233	5937										
C11orf80	79703	broad.mit.edu	37	chr11	66571581	66571581	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcatggacttgttgggagaaCtgatactgactccagcagct	12	9	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:66571581C>A	uc001ojf.2	+	9	965	c.958C>A	c.(958-960)CTG>ATG	p.L320M	C11orf80_uc001ojg.2_Missense_Mutation_p.L86M|C11orf80_uc001ojh.2_Missense_Mutation_p.L87M|C11orf80_uc001oji.2_Missense_Mutation_p.L87M|C11orf80_uc010rpk.1_Missense_Mutation_p.L155M	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	165											0						GTTGGGAGAACTGATACTGAC	0.463													1	0	1.59361e-14	0.006999	1.76421e-14	41	156										A	66571581	C	A	66571581	3	1	20	1	0	0	0	0	1	0	0	0	1664	564	20	4	992	4	C11orf80	11	66571581	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	437638	66571581	68434935	234	5938										
CLPB	81570	broad.mit.edu	37	chr11	72069953	72069953	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcagctccttgacagtgcggTagtcatcagcaagaacagca	11	11	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:72069953T>C	uc001osj.2	-	6	886	c.836A>G	c.(835-837)TAC>TGC	p.Y279C	CLPB_uc010rqx.1_Missense_Mutation_p.Y234C|CLPB_uc010rqy.1_Missense_Mutation_p.Y220C|CLPB_uc001osk.2_Missense_Mutation_p.Y249C|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Missense_Mutation_p.Y78C	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	279	ANK 3.				cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						GACAGTGCGGTAGTCATCAGC	0.413													0	0	0	0.003163	0	11	143										C	72069953	T	C	72069953	3	2	20	1	0	0	0	0	1	0	0	0	3551	1638	57	5	1335	5	CLPB	11	72069953	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	5498372	72069953	62936563	235	5939										
CHRDL2	25884	broad.mit.edu	37	chr11	74422031	74422031	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccggagtccagagggagtgtGaggttctgcagtgggggagg	21	6	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:74422031G>C	uc001ovi.2	-	4	548	c.295C>G	c.(295-297)CAC>GAC	p.H99D	CHRDL2_uc001ovg.2_5'UTR|CHRDL2_uc001ovh.2_Missense_Mutation_p.H99D|CHRDL2_uc001ovk.1_Missense_Mutation_p.H99D			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	99					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					GAGGGAGTGTGAGGTTCTGCA	0.517													0	0	0	0.006214	0	7	54										C	74422031	G	C	74422031	3	2	20	1	0	0	0	0	1	0	0	0	3374	1290	45	1	1096	1	CHRDL2	11	74422031	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2352078	74422031	60584485	236	5940										
SESN3	143686	broad.mit.edu	37	chr11	94910950	94910950	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catggttgtgtcaacatcctCatgggtggccatagtgttat	11	8	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:94910950C>T	uc001pfk.1	-	8	1402	c.1180G>A	c.(1180-1182)GAG>AAG	p.E394K	SESN3_uc010rug.1_Missense_Mutation_p.E255K	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	394					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TCAACATCCTCATGGGTGGCC	0.388													0	0	0	0.013537	0	11	84										T	94910950	C	T	94910950	3	4	20	1	0	0	0	0	1	0	0	0	14126	835	29	1	310	1	SESN3	11	94910950	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	20488919	94910950	40095566	237	5941										
YAP1	10413	broad.mit.edu	37	chr11	102100657	102100657	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agctagataaagaaagctttCttacatggttatagagccct	8	7	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:102100657C>T	uc001pgt.2	+	9	1871	c.1501C>T	c.(1501-1503)CTT>TTT	p.L501F	YAP1_uc001pgs.2_Missense_Mutation_p.L451F|YAP1_uc001pgu.2_Missense_Mutation_p.L485F|YAP1_uc001pgv.2_Missense_Mutation_p.L447F|YAP1_uc010ruo.1_Missense_Mutation_p.L323F|YAP1_uc001pgw.2_Missense_Mutation_p.L325F|YAP1_uc010rup.1_Missense_Mutation_p.L266F	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	501	Transactivation domain.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		AGAAAGCTTTCTTACATGGTT	0.438													0	0	0	0.00278	0	19	118										T	102100657	C	T	102100657	3	4	20	1	0	0	0	0	1	0	0	0	17463	913	32	1	1547	1	YAP1	11	102100657	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	7189707	102100657	32905859	238	5942										
DYNC2H1	79659	broad.mit.edu	37	chr11	103055726	103055726	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaattcattattaatctcatAaggggacttggtggaaatct	9	5	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:103055726A>G	uc001pho.2	+	41	6723	c.6579A>G	c.(6577-6579)ATA>ATG	p.I2193M	DYNC2H1_uc001phn.1_Missense_Mutation_p.I2193M|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2193					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTAATCTCATAAGGGGACTTG	0.348													0	0	0	0.00333	0	20	53										G	103055726	A	G	103055726	3	3	20	1	0	0	0	0	1	0	0	0	4846	352	13	5	6741	5	DYNC2H1	11	103055726	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	955069	103055726	31950790	239	5943										
DYNC2H1	79659	broad.mit.edu	37	chr11	103270433	103270433	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aagtgcctcctcctaacgatCgacaaggatctccaatactg	7	13	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:103270433C>T	uc001pho.2	+	84	12343	c.12199C>T	c.(12199-12201)CGA>TGA	p.R4067*	DYNC2H1_uc001phn.1_Nonsense_Mutation_p.R4074*|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4067					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCCTAACGATCGACAAGGATC	0.348													0	0	0	0.00499	0	13	31										T	103270433	C	T	103270433	4	4	20	1	0	0	0	0	0	1	0	0	4846	876	31	1	12558	1	DYNC2H1	11	103270433	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	214707	103270433	31736083	240	5944										
ATM	472	broad.mit.edu	37	chr11	108122629	108122629	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tccaggaacggtaaaaatggGaatagagcaaaatatgtgtg	12	4	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:108122629G>T	uc001pkb.1	+	11	2058	c.1673G>T	c.(1672-1674)GGA>GTA	p.G558V	ATM_uc009yxr.1_Missense_Mutation_p.G558V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	558					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.G558*(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTAAAAATGGGAATAGAGCAA	0.353			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			1	0	1.45105e-14	0.006122	1.61425e-14	16	87										T	108122629	G	T	108122629	3	4	20	1	0	0	0	0	1	0	0	0	1109	1174	41	3	1711	3	ATM	11	108122629	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4852196	108122629	26883887	241	5945										
ATM	472	broad.mit.edu	37	chr11	108201015	108201015	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	actgaaagaggatcgtaaacGcttcttatgtaaagcagttg	10	6	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:108201015G>C	uc001pkb.1	+	50	7767	c.7382G>C	c.(7381-7383)CGC>CCC	p.R2461P	ATM_uc009yxr.1_Missense_Mutation_p.R2461P|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.R1113P|ATM_uc001pkg.1_Missense_Mutation_p.R818P	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2461	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GATCGTAAACGCTTCTTATGT	0.388			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.010729	0	10	44										C	108201015	G	C	108201015	3	2	20	1	0	0	0	0	1	0	0	0	1109	1087	38	4	7576	4	ATM	11	108201015	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	78386	108201015	26805501	242	5946										
ASAM	79827	broad.mit.edu	37	chr11	122953891	122953891	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acatggtaagattctgcagcAgaactcgtccagggtggttg	13	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:122953891A>G	uc001pyt.2	-	5	940	c.581T>C	c.(580-582)CTG>CCG	p.L194P		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	194	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		ATTCTGCAGCAGAACTCGTCC	0.443													0	0	0	0.013537	0	11	134										G	122953891	A	G	122953891	3	3	20	1	0	0	0	0	1	0	0	0	1009	188	7	5	552	5	ASAM	11	122953891	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	14752876	122953891	12052625	243	5947										
ACRV1	56	broad.mit.edu	37	chr11	125547901	125547901	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cacctgaaggctgttctcctGaaggctgctcacctacagta	9	13	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr11:125547901G>A	uc001qcs.2	-	2	611	c.344C>T	c.(343-345)TCA>TTA	p.S115L	ACRV1_uc001qck.2_Missense_Mutation_p.S45L|ACRV1_uc001qcl.2_Missense_Mutation_p.S45L|ACRV1_uc001qcm.2_Intron|ACRV1_uc001qcn.2_Missense_Mutation_p.S60L|ACRV1_uc001qco.2_Intron|ACRV1_uc001qcp.2_Intron|ACRV1_uc001qcq.2_Missense_Mutation_p.S45L|ACRV1_uc001qcr.2_Missense_Mutation_p.S115L	NM_001612	NP_001603	P26436	ASPX_HUMAN	acrosomal vesicle protein 1 isoform a precursor	115	4 X 4 AA repeats of S-G-E-H.|3-2.|9 X 5 AA repeats of [SV]-G-E-Q-[PSA].				multicellular organismal development	acrosomal vesicle					0	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)		CTGTTCTCCTGAAGGCTGCTC	0.527													0	0	0	0.010729	0	11	160										A	125547901	G	A	125547901	3	1	20	1	0	0	0	0	1	0	0	0	172	1294	45	1	465	1	ACRV1	11	125547901	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2594010	125547901	9458615	244	5948										
KDM5A	5927	broad.mit.edu	37	chr12	431654	431654	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcagcttcttttacagcatcCctgagttttcgaaagagatc	7	10	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:431654C>T	uc001qif.1	-	17	2718	c.2355G>A	c.(2353-2355)AGG>AGA	p.R785R	KDM5A_uc001qie.1_Silent_p.R785R|KDM5A_uc010sdn.1_Silent_p.R744R	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	785					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TTACAGCATCCCTGAGTTTTC	0.373			T 	NUP98	AML								0	0	0	0.00499	0	16	143										T	431654	C	T	431654	2	4	20	1	0	0	0	0	0	0	0	1	8133	622	22	2		2	KDM5A	12	431654	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		431654	133420241	245	5949										
PLEKHA5	54477	broad.mit.edu	37	chr12	19427653	19427653	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttaacaaaaattaatagtgTaaagctgaattctctgccat	5	7	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:19427653T>A	uc001reb.2	+	10	1117	c.1031T>A	c.(1030-1032)GTA>GAA	p.V344E	PLEKHA5_uc010sie.1_Missense_Mutation_p.V350E|PLEKHA5_uc001rea.2_Missense_Mutation_p.V344E|PLEKHA5_uc009zin.2_Missense_Mutation_p.V102E|PLEKHA5_uc010sif.1_Missense_Mutation_p.V236E|PLEKHA5_uc010sig.1_Missense_Mutation_p.V236E|PLEKHA5_uc010sih.1_Missense_Mutation_p.V236E|PLEKHA5_uc001rec.1_Missense_Mutation_p.V32E	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	344							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ATTAATAGTGTAAAGCTGAAT	0.383													0	0	0	0.005443	0	23	127										A	19427653	T	A	19427653	3	1	20	1	0	0	0	0	1	0	0	0	12059	1638	57	5	1069	5	PLEKHA5	12	19427653	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	18995999	19427653	114424242	246	5950										
C12orf77	196415	broad.mit.edu	37	chr12	25148970	25148970	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttgtttgctcccagtgggtaGagaacccggcattgtgggta	14	8	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:25148970G>C	uc001rgf.2	-	3	383	c.178C>G	c.(178-180)CTA>GTA	p.L60V		NM_001101339	NP_001094809	C9JDV5	CL097_HUMAN	hypothetical protein LOC196415	60											0						CCAGTGGGTAGAGAACCCGGC	0.458													0	0	0	0.001168	0	5	42										C	25148970	G	C	25148970	3	2	20	1	0	0	0	0	1	0	0	0	1716	933	33	1	267	1	C12orf77	12	25148970	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	5721317	25148970	108702925	247	5951										
ITPR2	3709	broad.mit.edu	37	chr12	26647234	26647234	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gacactgaatgtctgacattGatatccccatcttatctgaa	6	10	3	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:26647234G>A	uc001rhg.2	-	39	5639	c.5222C>T	c.(5221-5223)TCA>TTA	p.S1741L	ITPR2_uc009zjg.1_5'UTR	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1741	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GTCTGACATTGATATCCCCAT	0.338													0	0	0	0.007413	0	13	53										A	26647234	G	A	26647234	3	1	20	1	0	0	0	0	1	0	0	0	7921	1294	45	1	2959	1	ITPR2	12	26647234	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1498264	26647234	107204661	248	5952										
TM7SF3	51768	broad.mit.edu	37	chr12	27135731	27135731	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttccagaatctgtgtccaaaGaaacaaatgaagaaaccaag	7	8	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:27135731G>C	uc010sjl.1	-	7	1168	c.930C>G	c.(928-930)TTC>TTG	p.F310L		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	310	Phe-rich.|Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					TGTGTCCAAAGAAACAAATGA	0.368													0	0	0	0.00308	0	6	36										C	27135731	G	C	27135731	3	2	20	1	0	0	0	0	1	0	0	0	15972	933	33	1	806	1	TM7SF3	12	27135731	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	488497	27135731	106716164	249	5953										
FAM60A	58516	broad.mit.edu	37	chr12	31446847	31446847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgtagtctttagactgggtcCagcccttgcatctaccacct	8	13	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:31446847C>T	uc010sjz.1	-	4	486	c.247G>A	c.(247-249)GGA>AGA	p.G83R	FAM60A_uc001rkd.2_Missense_Mutation_p.G83R|FAM60A_uc010ska.1_Missense_Mutation_p.G83R|FAM60A_uc001rke.2_Missense_Mutation_p.G83R|FAM60A_uc010skb.1_Intron|FAM60A_uc001rkc.2_Missense_Mutation_p.G108R	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	83											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					AGACTGGGTCCAGCCCTTGCA	0.368													0	0	0	0.010729	0	11	71										T	31446847	C	T	31446847	3	4	20	1	0	0	0	0	1	0	0	0	5595	603	21	2	430	2	FAM60A	12	31446847	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	4311116	31446847	102405048	250	5954										
MLL2	8085	broad.mit.edu	37	chr12	49433004	49433004	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggaacctcctggagcctcaCcggctgttcacatccataga	10	14	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:49433004C>A	uc001rta.3	-	33	8366	c.8366_splice	c.e33+1	p.R2789_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGAGCCTCACCGGCTGTTCA	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	9.8876e-21	0.004878	1.12191e-20	27	143										A	49433004	C	A	49433004	5	1	20	1	0	0	0	0	0	0	1	0	9621	521	18	4	8334	4	MLL2	12	49433004	Splice_Site	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	17986157	49433004	84418891	251	5955										
METTL7A	25840	broad.mit.edu	37	chr12	51318851	51318851	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	accatctttatcctgagactGgccatttacatcctgacatt	5	12	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:51318851G>C	uc001rxb.2	+	1	318	c.30G>C	c.(28-30)CTG>CTC	p.L10L	METTL7A_uc010smv.1_Silent_p.L10L	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	10	Targeting to lipid droplets.					endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						TCCTGAGACTGGCCATTTACA	0.453													0	0	0	0.012213	0	26	144										C	51318851	G	C	51318851	2	2	20	1	0	0	0	0	0	0	0	1	9505	1335	47	4		4	METTL7A	12	51318851	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1885847	51318851	82533044	252	5956										
SLC4A8	9498	broad.mit.edu	37	chr12	51865155	51865155	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	attgtccttgtggcaactgaTgccagttcccttgtctgcta	9	11	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:51865155T>C	uc001rys.1	+	14	1921	c.1743T>C	c.(1741-1743)GAT>GAC	p.D581D	SLC4A8_uc010sni.1_Silent_p.D528D|SLC4A8_uc001rym.2_Silent_p.D528D|SLC4A8_uc001ryn.2_Silent_p.D528D|SLC4A8_uc001ryo.2_Silent_p.D528D|SLC4A8_uc010snj.1_Silent_p.D608D|SLC4A8_uc001ryq.3_Silent_p.D581D|SLC4A8_uc001ryr.2_Silent_p.D581D|SLC4A8_uc010snk.1_Silent_p.D528D	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	581	Helical; (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGGCAACTGATGCCAGTTCCC	0.428													0	0	0	0.003271	0	31	146										C	51865155	T	C	51865155	2	2	20	1	0	0	0	0	0	0	0	1	14659	1461	51	5		5	SLC4A8	12	51865155	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	546304	51865155	81986740	253	5957										
SP1	6667	broad.mit.edu	37	chr12	53775912	53775912	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggagtcccagccatcccctTtggctctgctggcagcaact	10	15	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:53775912T>G	uc001scw.2	+	3	278	c.181T>G	c.(181-183)TTG>GTG	p.L61V	SP1_uc010sog.1_Missense_Mutation_p.L54V	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	61	Ser/Thr-rich.|Repressor domain.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GCCATCCCCTTTGGCTCTGCT	0.542											OREG0021870	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	16	75										G	53775912	T	G	53775912	3	3	20	1	0	0	0	0	1	0	0	0	14959	1838	64	5	191	5	SP1	12	53775912	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	1910757	53775912	80075983	254	5958										
HNRNPA1	3178	broad.mit.edu	37	chr12	54675607	54675607	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agatccaaacaccaagcgctCcaggggctttgggtttgtca	11	11	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:54675607C>G	uc001sfl.2	+	3	265	c.161C>G	c.(160-162)TCC>TGC	p.S54C	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.S54C|HNRNPA1_uc009zng.2_Missense_Mutation_p.S54C|HNRNPA1_uc009znh.2_Missense_Mutation_p.S54C|HNRNPA1_uc009zni.2_Missense_Mutation_p.S54C|HNRNPA1_uc001sfn.2_Missense_Mutation_p.S54C|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.S9C|HNRNPA1_uc009znj.1_Missense_Mutation_p.S9C	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	54	Globular A domain.|RRM 1.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						ACCAAGCGCTCCAGGGGCTTT	0.448													0	0	0	0.004482	0	7	30										G	54675607	C	G	54675607	3	3	20	1	0	0	0	0	1	0	0	0	7257	855	30	1	171	1	HNRNPA1	12	54675607	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	899695	54675607	79176288	255	5959										
INHBE	83729	broad.mit.edu	37	chr12	57850077	57850077	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agcaccacatcaccaacctgGgctggcataccttaactctg	7	15	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:57850077G>A	uc001snw.2	+	2	723	c.499G>A	c.(499-501)GGC>AGC	p.G167S		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	167					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						CACCAACCTGGGCTGGCATAC	0.577											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	87	336										A	57850077	G	A	57850077	3	1	20	1	0	0	0	0	1	0	0	0	7744	1232	43	2	505	2	INHBE	12	57850077	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3174470	57850077	76001818	256	5960										
TMEM5	10329	broad.mit.edu	37	chr12	64195998	64195998	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agtggttactttatgcacaaAatttagtgcaaattcaaaaa	6	5	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:64195998A>C	uc001srq.1	+	4	660	c.556A>C	c.(556-558)AAT>CAT	p.N186H	TMEM5_uc001srr.1_Missense_Mutation_p.N83H|TMEM5_uc001srs.1_5'UTR	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	186	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TTATGCACAAAATTTAGTGCA	0.363													0	0	0	0.009096	0	4	62										C	64195998	A	C	64195998	3	2	20	1	0	0	0	0	1	0	0	0	16171	14	1	5	570	5	TMEM5	12	64195998	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	6345921	64195998	69655897	257	5961										
IRAK3	11213	broad.mit.edu	37	chr12	66605244	66605244	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggaatactgcttaaatcttCcatcagctttcaaaatatca	4	9	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:66605244C>G	uc001sth.2	+	5	557	c.455C>G	c.(454-456)TCC>TGC	p.S152C	IRAK3_uc010ssy.1_Missense_Mutation_p.S91C	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	152					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		CTTAAATCTTCCATCAGCTTT	0.338													0	0	0	0.001168	0	6	47										G	66605244	C	G	66605244	3	3	20	1	0	0	0	0	1	0	0	0	7824	855	30	1	473	1	IRAK3	12	66605244	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2409246	66605244	67246651	258	5962										
PTPRR	5801	broad.mit.edu	37	chr12	71139613	71139613	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttacctctcttgaagtcctAtgggcttcattttgaaagga	8	9	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:71139613A>G	uc001swi.1	-	6	1408	c.992T>C	c.(991-993)ATA>ACA	p.I331T	PTPRR_uc001swh.1_Missense_Mutation_p.I86T|PTPRR_uc009zrs.2_Missense_Mutation_p.I180T|PTPRR_uc010stq.1_Missense_Mutation_p.I219T|PTPRR_uc010str.1_Missense_Mutation_p.I180T	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	331	Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TTGAAGTCCTATGGGCTTCAT	0.423													0	0	0	0.001168	0	5	49										G	71139613	A	G	71139613	3	3	20	1	0	0	0	0	1	0	0	0	12810	449	16	5	1017	5	PTPRR	12	71139613	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	4534369	71139613	62712282	259	5963										
TRHDE	29953	broad.mit.edu	37	chr12	72667281	72667281	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	attatctacaacgcgctcatCgagaatgagctcctgggctt	9	11	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:72667281C>G	uc001sxa.2	+	1	753	c.723C>G	c.(721-723)ATC>ATG	p.I241M	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	241	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ACGCGCTCATCGAGAATGAGC	0.587													0	0	0	0.014323	0	20	101										G	72667281	C	G	72667281	3	3	20	1	0	0	0	0	1	0	0	0	16476	874	31	1	725	1	TRHDE	12	72667281	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1527668	72667281	61184614	260	5964										
GLIPR1L2	144321	broad.mit.edu	37	chr12	75784898	75784898	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgtcagcggccggtggaccaTggaggccgcaaggcccttcg	16	13	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:75784898T>C	uc001sxr.1	+	1	10	c.2T>C	c.(1-3)ATG>ACG	p.M1T	CAPS2_uc001sxm.3_5'Flank|CAPS2_uc009zsa.2_5'Flank|GLIPR1L2_uc001sxp.1_Missense_Mutation_p.M1T|GLIPR1L2_uc001sxq.1_5'UTR	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	1						integral to membrane				ovary(1)	1						CGGTGGACCATGGAGGCCGCA	0.682											OREG0021999	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	3	21										C	75784898	T	C	75784898	3	2	20	1	0	0	0	0	1	0	0	0	6443	1464	51	5	4	5	GLIPR1L2	12	75784898	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	3117617	75784898	58066997	261	5965										
LRRIQ1	84125	broad.mit.edu	37	chr12	85459088	85459088	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caggctgtgttctctccacaCtggcagagtgtacaaatctt	9	11	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:85459088C>T	uc001tac.2	+	9	2551	c.2440C>T	c.(2440-2442)CTG>TTG	p.L814L	LRRIQ1_uc001tab.1_Silent_p.L814L	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	814										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TCTCTCCACACTGGCAGAGTG	0.383													0	0	0	0.003954	0	22	114										T	85459088	C	T	85459088	2	4	20	1	0	0	0	0	0	0	0	1	9029	564	20	2		2	LRRIQ1	12	85459088	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	9674190	85459088	48392807	262	5966										
USP44	84101	broad.mit.edu	37	chr12	95926706	95926706	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aagagctggtaaactggtacCagttgtctctaattcacgtt	9	8	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:95926706C>T	uc001teg.2	-	2	1471	c.1327G>A	c.(1327-1329)GGT>AGT	p.G443S	USP44_uc001teh.2_Missense_Mutation_p.G443S|USP44_uc009zte.2_Missense_Mutation_p.G440S	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	443					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						AAACTGGTACCAGTTGTCTCT	0.388													0	0	0	0.010729	0	10	54										T	95926706	C	T	95926706	3	4	20	1	0	0	0	0	1	0	0	0	17072	594	21	2	831	2	USP44	12	95926706	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	10467618	95926706	37925189	263	5967										
HAL	3034	broad.mit.edu	37	chr12	96370219	96370219	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagcttgccttctgctccagGagcagcctgtgggctgcctc	12	15	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:96370219G>A	uc001tem.1	-	20	2118	c.1821C>T	c.(1819-1821)CTC>CTT	p.L607L	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Silent_p.L399L|HAL_uc010sux.1_Intron	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	607					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	TCTGCTCCAGGAGCAGCCTGT	0.507													0	0	0	0.00278	0	19	96										A	96370219	G	A	96370219	2	1	20	1	0	0	0	0	0	0	0	1	6947	1161	41	1		1	HAL	12	96370219	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	443513	96370219	37481676	264	5968										
APAF1	317	broad.mit.edu	37	chr12	99076995	99076995	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caagtcaattgctgccatttCaccaacagtagtcatcatct	5	12	5	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:99076995C>T	uc001tfz.2	+	15	2698	c.2121C>T	c.(2119-2121)TTC>TTT	p.F707F	APAF1_uc001tfy.2_Silent_p.F696F|APAF1_uc001tga.2_Silent_p.F696F|APAF1_uc001tgb.2_Silent_p.F707F|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Silent_p.F116F	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	707	WD 3.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	GCTGCCATTTCACCAACAGTA	0.383													0	0	0	0.014323	0	19	183										T	99076995	C	T	99076995	2	4	20	1	0	0	0	0	0	0	0	1	755	825	29	1		1	APAF1	12	99076995	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2706776	99076995	34774900	265	5969										
C12orf48	55010	broad.mit.edu	37	chr12	102589201	102589201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catcaaagcctttgtgtgttCtttacatggaaaatgacctt	7	8	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:102589201C>T	uc001tjf.2	+	10	1487	c.1375C>T	c.(1375-1377)CTT>TTT	p.L459F	C12orf48_uc001tjg.2_Missense_Mutation_p.L378F|C12orf48_uc010swa.1_Missense_Mutation_p.L536F|C12orf48_uc001tjh.2_Missense_Mutation_p.L378F|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.L174F|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	459					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						TTTGTGTGTTCTTTACATGGA	0.264													0	0	0	0.006122	0	15	142										T	102589201	C	T	102589201	3	4	20	1	0	0	0	0	1	0	0	0	1692	913	32	1	1162	1	C12orf48	12	102589201	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3512206	102589201	31262694	266	5970										
NOS1	4842	broad.mit.edu	37	chr12	117696896	117696896	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cacaaggaccagagtttcatGttccaggtgcacaatgtcat	9	10	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:117696896G>C	uc001twm.1	-	15	3093	c.2407C>G	c.(2407-2409)CAT>GAT	p.H803D	NOS1_uc001twn.1_5'Flank	NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	803	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGAGTTTCATGTTCCAGGTGC	0.408													0	0	0	0.010729	0	9	102										C	117696896	G	C	117696896	3	2	20	1	0	0	0	0	1	0	0	0	10541	1377	48	4	1957	4	NOS1	12	117696896	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	15107695	117696896	16154999	267	5971										
COX6A1	1337	broad.mit.edu	37	chr12	120875952	120875952	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggcggtagttggtgtgtcctCggtttctcggctgctgggtc	17	9	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:120875952C>T	uc001tyf.1	+	1	49	c.23C>T	c.(22-24)TCG>TTG	p.S8L		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	8					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTGTCCTCGGTTTCTCGG	0.637													0	0	0	0.00308	0	6	32										T	120875952	C	T	120875952	3	4	20	1	0	0	0	0	1	0	0	0	3774	893	31	1	25	1	COX6A1	12	120875952	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3179056	120875952	12975943	268	5972										
C12orf43	64897	broad.mit.edu	37	chr12	121454163	121454163	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttccctgccacgtgcgggcGttgctccaagccccaagccg	11	18	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:121454163G>A	uc001tzh.1	-	1	138	c.115C>T	c.(115-117)CGC>TGC	p.R39C	C12orf43_uc009zxa.1_Missense_Mutation_p.R39C|C12orf43_uc010szo.1_Translation_Start_Site|C12orf43_uc010szp.1_Missense_Mutation_p.R39C|C12orf43_uc001tzi.1_Missense_Mutation_p.R39C	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	39											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACGTGCGGGCGTTGCTCCAAG	0.627													0	0	0	0.008291	0	10	50										A	121454163	G	A	121454163	3	1	20	1	0	0	0	0	1	0	0	0	1689	1145	40	2	697	2	C12orf43	12	121454163	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	578211	121454163	12397732	269	5973										
KNTC1	9735	broad.mit.edu	37	chr12	123087591	123087591	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aagttctctctggacactctGtacgtgtctacagcaaaaca	7	11	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr12:123087591G>A	uc001ucv.2	+	48	5065	c.4902G>A	c.(4900-4902)CTG>CTA	p.L1634L	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1634					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TGGACACTCTGTACGTGTCTA	0.363													0	0	0	0.004672	0	3	24										A	123087591	G	A	123087591	2	1	20	1	0	0	0	0	0	0	0	1	8428	1364	48	2		2	KNTC1	12	123087591	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1633428	123087591	10764304	270	5974										
UFM1	51569	broad.mit.edu	37	chr13	38924164	38924164	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttcctttaagatcacgctgAcgtcggacccacggctgccg	10	14	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:38924164A>T	uc001uwu.2	+	2	146	c.31A>T	c.(31-33)ACG>TCG	p.T11S	UFM1_uc010abz.2_Missense_Mutation_p.T11S|UFM1_uc010aca.2_Missense_Mutation_p.T11S	NM_016617	NP_057701	P61960	UFM1_HUMAN	ubiquitin-fold modifier 1 precursor	11					protein ufmylation	cytoplasm|nucleus	protein binding				0		Lung NSC(96;3.18e-06)|Prostate(109;0.00314)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;1.05e-08)|Epithelial(112;1.44e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000855)|BRCA - Breast invasive adenocarcinoma(63;0.00342)|GBM - Glioblastoma multiforme(144;0.0132)		GATCACGCTGACGTCGGACCC	0.582													0	0	0	0.010504	0	19	126										T	38924164	A	T	38924164	3	4	20	1	0	0	0	0	1	0	0	0	16933	275	10	5	37	5	UFM1	13	38924164	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08		38924164	76245714	271	5975										
FREM2	341640	broad.mit.edu	37	chr13	39446912	39446912	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgcagtcctatgtgacccttCgagtccctctgtatgtttcc	8	13	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:39446912C>T	uc001uwv.2	+	17	8326	c.8017C>T	c.(8017-8019)CGA>TGA	p.R2673*		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2673	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTGACCCTTCGAGTCCCTCT	0.438													0	0	0	0.003954	0	21	91										T	39446912	C	T	39446912	4	4	20	1	0	0	0	0	0	1	0	0	6045	876	31	1	8083	1	FREM2	13	39446912	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	522748	39446912	75722966	272	5976										
AKAP11	11215	broad.mit.edu	37	chr13	42876351	42876351	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctgagaatgaacaaaatactAtagaaaaagaagagttcatg	8	4	1	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:42876351A>G	uc001uys.1	+	8	3644	c.3469A>G	c.(3469-3471)ATA>GTA	p.I1157V		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1157					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		ACAAAATACTATAGAAAAAGA	0.423													0	0	0	0.000602	0	5	115										G	42876351	A	G	42876351	3	3	20	1	0	0	0	0	1	0	0	0	447	449	16	5	3491	5	AKAP11	13	42876351	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	3429439	42876351	72293527	273	5977										
RCBTB2	1102	broad.mit.edu	37	chr13	49064303	49064303	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gataaagttcttcaggagatCatggtccatttctgcaaaac	8	8	4	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:49064303C>T	uc001vch.2	-	15	1971	c.1600G>A	c.(1600-1602)GAT>AAT	p.D534N	RCBTB2_uc001vcg.2_RNA|RCBTB2_uc010tgg.1_Missense_Mutation_p.D539N|RCBTB2_uc001vci.2_Missense_Mutation_p.D510N|RCBTB2_uc010tgh.1_Missense_Mutation_p.D260N|RCBTB2_uc001vcj.2_Missense_Mutation_p.D486N	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	534							Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		TTCAGGAGATCATGGTCCATT	0.398													0	0	0	0.006214	0	7	106										T	49064303	C	T	49064303	3	4	20	1	0	0	0	0	1	0	0	0	13172	826	29	1	59	1	RCBTB2	13	49064303	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	6187952	49064303	66105575	274	5978										
KLHL1	57626	broad.mit.edu	37	chr13	70535552	70535552	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtaaacatggccgcaaaataGtcggagactgaactcagaac	10	9	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:70535552G>T	uc001vip.2	-	3	1499	c.705C>A	c.(703-705)GAC>GAA	p.D235E	KLHL1_uc010thm.1_Missense_Mutation_p.D174E	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	235	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCGCAAAATAGTCGGAGACTG	0.443													1	0	6.40141e-05	0.010729	6.60463e-05	10	58										T	70535552	G	T	70535552	3	4	20	1	0	0	0	0	1	0	0	0	8365	1020	36	4	1577	4	KLHL1	13	70535552	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	21471249	70535552	44634326	275	5979										
C13orf34	79866	broad.mit.edu	37	chr13	73305498	73305498	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agacccagaagatattcatcGtcaagctttatacttaagtc	6	9	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:73305498G>C	uc001viv.1	+	3	352	c.233G>C	c.(232-234)CGT>CCT	p.R78P	C13orf34_uc010thq.1_5'UTR|C13orf34_uc010aen.1_Missense_Mutation_p.R153P|C13orf34_uc010thr.1_Intron|C13orf34_uc001viw.1_Intron	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	78					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		GATATTCATCGTCAAGCTTTA	0.353													0	0	0	0.001984	0	5	95										C	73305498	G	C	73305498	3	2	20	1	0	0	0	0	1	0	0	0	1728	1145	40	4	239	4	C13orf34	13	73305498	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2769946	73305498	41864380	276	5980										
LMO7	4008	broad.mit.edu	37	chr13	76397778	76397778	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aatgtggtcagcacccctgcAccaagcccggacgcaagcca	10	16	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:76397778A>G	uc001vjv.2	+	12	2779	c.2019A>G	c.(2017-2019)GCA>GCG	p.A673A	LMO7_uc010thv.1_Silent_p.A624A|LMO7_uc001vjt.1_Silent_p.A572A|LMO7_uc010thw.1_Silent_p.A523A|LMO7_uc001vjw.1_Silent_p.A579A	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	958						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GCACCCCTGCACCAAGCCCGG	0.453													0	0	0	0.00278	0	23	87										G	76397778	A	G	76397778	2	3	20	1	0	0	0	0	0	0	0	1	8855	146	6	5		5	LMO7	13	76397778	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	3092280	76397778	38772100	277	5981										
EDNRB	1910	broad.mit.edu	37	chr13	78477304	78477304	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aatttacctgcatgaaagctGtcttctgaacgggatgaagc	10	8	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:78477304G>A	uc001vko.2	-	3	1046	c.788C>T	c.(787-789)ACA>ATA	p.T263I	EDNRB_uc001vkq.1_Missense_Mutation_p.T263I|uc001vkn.1_Intron|EDNRB_uc010aez.1_Missense_Mutation_p.T263I|EDNRB_uc001vkp.1_Missense_Mutation_p.T346I	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	263	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CATGAAAGCTGTCTTCTGAAC	0.403													0	0	0	0.006122	0	13	83										A	78477304	G	A	78477304	3	1	20	1	0	0	0	0	1	0	0	0	4920	1377	48	2	681	2	EDNRB	13	78477304	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2079526	78477304	36692574	278	5982										
CLYBL	171425	broad.mit.edu	37	chr13	100425084	100425084	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cacgtgtcttgcaggaaagcGtctctagcagctgatatccc	10	12	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:100425084G>A	uc001vok.2	+	2	83	c.69G>A	c.(67-69)GCG>GCA	p.A23A	CLYBL_uc010tix.1_Silent_p.A23A|CLYBL_uc010tiy.1_Silent_p.A23A	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	23					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCAGGAAAGCGTCTCTAGCAG	0.393													0	0	0	0.005524	0	33	174										A	100425084	G	A	100425084	2	1	20	1	0	0	0	0	0	0	0	1	3573	1132	40	2		2	CLYBL	13	100425084	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	21947780	100425084	14744794	279	5983										
TNFSF13B	10673	broad.mit.edu	37	chr13	108922324	108922325	+	Missense_Mutation	DNP	TG	TG	GA													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaaatgaaactgaaggagtgTgtttccatcctcccacggaa							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:108922324_108922325TG>GA	uc001vqr.2	+	1	348_349	c.81_82TG>GA	c.(79-84)TGTGTT>TGGATT	p.27_28CV>WI	TNFSF13B_uc010agj.2_Missense_Mutation_p.27_28CV>WI	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	27_28	Cytoplasmic (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			TGAAGGAGTGTGTTTCCATCCT	0.495													0	0	0	0.004672	0	12	219										GA	108922325	TG	GA	108922324	3	3	20	1	0	0	0	0	1	0	0	0	16303	1702	59	5	83	5	TNFSF13B	13	108922324	Missense_Mutation	DNP	TG	TCGA-BT-A3PK-01A-21D-A21Z-08	8497240	108922324	6247554	280	5984										
MYO16	23026	broad.mit.edu	37	chr13	109672259	109672259	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atcatgcactacgcaggaagGgtaagtggccagaactgcat	12	9	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr13:109672259G>A	uc001vqt.1	+	23	2856	c.2730G>A	c.(2728-2730)AGG>AGA	p.R910R	MYO16_uc010agk.1_Silent_p.R932R|MYO16_uc001vqu.1_Silent_p.R710R|MYO16_uc010tjh.1_Silent_p.R422R	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	910	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ACGCAGGAAGGGTAAGTGGCC	0.448													0	0	0	0.010729	0	10	65										A	109672259	G	A	109672259	2	1	20	1	0	0	0	0	0	0	0	1	10064	1246	43	2		2	MYO16	13	109672259	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	749935	109672259	5497619	281	5985										
CHD8	57680	broad.mit.edu	37	chr14	21870182	21870182	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtagttcgtcttaacaagatCtggtcaatgtcctcttcaca	7	10	5	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:21870182C>T	uc001was.1	-	20	3253	c.3159G>A	c.(3157-3159)CAG>CAA	p.Q1053Q	CHD8_uc001war.1_Silent_p.Q949Q|CHD8_uc001wav.1_Silent_p.Q495Q	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1332					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTAACAAGATCTGGTCAATGT	0.413													0	0	0	0.001855	0	12	156										T	21870182	C	T	21870182	2	4	20	1	0	0	0	0	0	0	0	1	3331	912	32	1		1	CHD8	14	21870182	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		21870182	85479358	282	5986										
CHD8	57680	broad.mit.edu	37	chr14	21870572	21870572	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caacttgaggctggccttatCaaacatctctctctcgtagg	8	12	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:21870572C>G	uc001was.1	-	19	3062	c.2968G>C	c.(2968-2970)GAT>CAT	p.D990H	CHD8_uc001war.1_Missense_Mutation_p.D886H|CHD8_uc001wav.1_Missense_Mutation_p.D432H	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1269	Helicase C-terminal.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CTGGCCTTATCAAACATCTCT	0.483													0	0	0	0.001984	0	6	116										G	21870572	C	G	21870572	3	3	20	1	0	0	0	0	1	0	0	0	3331	826	29	1	4020	1	CHD8	14	21870572	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	390	21870572	85478968	283	5987										
DCAF11	80344	broad.mit.edu	37	chr14	24588376	24588376	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagatgagcgtcgctttgctGtcttctccattgctgtctcc	9	13	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:24588376G>C	uc001wlv.2	+	9	1082	c.802G>C	c.(802-804)GTC>CTC	p.V268L	DCAF11_uc001wlw.2_Missense_Mutation_p.V268L|DCAF11_uc001wlz.2_Missense_Mutation_p.V168L|DCAF11_uc001wly.2_Missense_Mutation_p.V224L|DCAF11_uc001wme.2_Missense_Mutation_p.V228L|DCAF11_uc010tny.1_Missense_Mutation_p.V135L|DCAF11_uc001wmd.2_Missense_Mutation_p.V268L|DCAF11_uc001wmc.2_Missense_Mutation_p.V168L|DCAF11_uc001wmb.3_Missense_Mutation_p.V242L|DCAF11_uc001wma.3_Missense_Mutation_p.V268L	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	268	WD 3.					CUL4 RING ubiquitin ligase complex	protein binding				0						TCGCTTTGCTGTCTTCTCCAT	0.463													0	0	0	0.00278	0	17	155										C	24588376	G	C	24588376	3	2	20	1	0	0	0	0	1	0	0	0	4262	1377	48	4	832	4	DCAF11	14	24588376	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2717804	24588376	82761164	284	5988										
MAPK1IP1L	93487	broad.mit.edu	37	chr14	55529993	55529993	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctactcccagtaatcctttcCaagtgccttcaggaccttct	5	15	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:55529993C>T	uc001xbq.1	+	3	840	c.676C>T	c.(676-678)CAA>TAA	p.Q226*		NM_144578	NP_653179	Q8NDC0	MISSL_HUMAN	MAPK-interacting and spindle-stabilizing	226	Pro-rich.										0						TAATCCTTTCCAAGTGCCTTC	0.512													0	0	0	0.006214	0	9	102										T	55529993	C	T	55529993	4	4	20	1	0	0	0	0	0	1	0	0	9278	595	21	2	682	2	MAPK1IP1L	14	55529993	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	30941617	55529993	51819547	285	5989										
KCNH5	27133	broad.mit.edu	37	chr14	63174336	63174336	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gagtggcatttgggatttggGagatgaggcctggggtacgc	19	5	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:63174336G>C	uc001xfx.2	-	11	2908	c.2857C>G	c.(2857-2859)CCC>GCC	p.P953A	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	953	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGGGATTTGGGAGATGAGGCC	0.463													0	0	0	0.010504	0	19	211										C	63174336	G	C	63174336	3	2	20	1	0	0	0	0	1	0	0	0	8035	1174	41	1	113	1	KCNH5	14	63174336	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	7644343	63174336	44175204	286	5990										
KCNH5	27133	broad.mit.edu	37	chr14	63174651	63174651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggtcacactgttctctgaatCactgctcttggggtcctcag	10	12	5	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:63174651C>G	uc001xfx.2	-	11	2593	c.2542G>C	c.(2542-2544)GAT>CAT	p.D848H	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	848	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCTCTGAATCACTGCTCTTG	0.438													0	0	0	0.003163	0	12	117										G	63174651	C	G	63174651	3	3	20	1	0	0	0	0	1	0	0	0	8035	826	29	1	428	1	KCNH5	14	63174651	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	315	63174651	44174889	287	5991										
FUT8	2530	broad.mit.edu	37	chr14	66208906	66208906	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atctactattttgggggccaGaatgcccacaatcaaattgc	8	10	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:66208906G>C	uc001xin.2	+	11	2703	c.1506G>C	c.(1504-1506)CAG>CAC	p.Q502H	FUT8_uc001xio.2_Missense_Mutation_p.Q502H|FUT8_uc010tsp.1_Missense_Mutation_p.Q339H|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.Q502H|FUT8_uc001xiq.2_Missense_Mutation_p.Q373H|FUT8_uc001xis.2_Missense_Mutation_p.Q96H	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	502	SH3.|Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TTGGGGGCCAGAATGCCCACA	0.433													0	0	0	0.004482	0	8	172										C	66208906	G	C	66208906	3	2	20	1	0	0	0	0	1	0	0	0	6110	933	33	1	1639	1	FUT8	14	66208906	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3034255	66208906	41140634	288	5992										
PLEKHH1	57475	broad.mit.edu	37	chr14	68040539	68040539	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtgatgtcatccggaaacctCaaggccaagtggatctgaac	11	10	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:68040539C>T	uc001xjl.1	+	13	2003	c.1861C>T	c.(1861-1863)CAA>TAA	p.Q621*	PLEKHH1_uc010tsw.1_Nonsense_Mutation_p.Q189*|PLEKHH1_uc001xjm.1_Nonsense_Mutation_p.Q136*|PLEKHH1_uc001xjn.1_Nonsense_Mutation_p.Q136*	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	621	PH 1.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCGGAAACCTCAAGGCCAAGT	0.502													0	0	0	0.006214	0	7	131										T	68040539	C	T	68040539	4	4	20	1	0	0	0	0	0	1	0	0	12076	827	29	1	1907	1	PLEKHH1	14	68040539	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1831633	68040539	39309001	289	5993										
PLEKHH1	57475	broad.mit.edu	37	chr14	68040602	68040602	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggagggttcacagacgtttCaggtgagcacgctcctggct	15	10	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:68040602C>G	uc001xjl.1	+	13	2066	c.1924C>G	c.(1924-1926)CAG>GAG	p.Q642E	PLEKHH1_uc010tsw.1_Missense_Mutation_p.Q210E|PLEKHH1_uc001xjm.1_Missense_Mutation_p.Q157E|PLEKHH1_uc001xjn.1_Missense_Mutation_p.Q157E	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	642	PH 1.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		ACAGACGTTTCAGGTGAGCAC	0.488													0	0	0	0.004482	0	7	93										G	68040602	C	G	68040602	3	3	20	1	0	0	0	0	1	0	0	0	12076	827	29	1	1970	1	PLEKHH1	14	68040602	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	63	68040602	39308938	290	5994										
ANGEL1	23357	broad.mit.edu	37	chr14	77255678	77255678	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccagagtatctcttcagagaGaagggagagacgacccagga	13	9	2	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:77255678G>A	uc001xsv.2	-	10	2019	c.1906C>T	c.(1906-1908)CTC>TTC	p.L636F	uc001xsu.1_5'Flank|ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	636										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TCTTCAGAGAGAAGGGAGAGA	0.562													0	0	0	0.007413	0	14	169										A	77255678	G	A	77255678	3	1	20	1	0	0	0	0	1	0	0	0	608	942	33	1	110	1	ANGEL1	14	77255678	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	9215076	77255678	30093862	291	5995										
STON2	85439	broad.mit.edu	37	chr14	81743987	81743987	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccaactgtgctcaagtccatTgacaacactggcagatccat	7	13	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:81743987T>C	uc010tvu.1	-	4	1869	c.1668A>G	c.(1666-1668)TCA>TCG	p.S556S	STON2_uc001xvk.1_Silent_p.S556S|STON2_uc010tvt.1_Silent_p.S353S	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	556	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TCAAGTCCATTGACAACACTG	0.478													0	0	0	0.001168	0	6	43										C	81743987	T	C	81743987	2	2	20	1	0	0	0	0	0	0	0	1	15317	1799	63	5		5	STON2	14	81743987	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	4488309	81743987	25605553	292	5996										
SEL1L	6400	broad.mit.edu	37	chr14	81950697	81950697	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atctacatcggtgccaaaccCatagaaatggtagtctccga	8	11	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:81950697C>A	uc010tvv.1	-	19	2035	c.1918G>T	c.(1918-1920)GGG>TGG	p.G640W		NM_005065	NP_005056	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like precursor	640	Lumenal (Potential).|Interaction with ERLEC1, OS9 and SYVN1.|Sel1-like 10.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)		GTGCCAAACCCATAGAAATGG	0.368													1	0	2.4624e-09	0.008871	2.65495e-09	18	161										A	81950697	C	A	81950697	3	1	20	1	0	0	0	0	1	0	0	0	14010	594	21	4	478	4	SEL1L	14	81950697	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	206710	81950697	25398843	293	5997										
SPATA7	55812	broad.mit.edu	37	chr14	88883148	88883148	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aactgcaatgcgagccaattAtaaaaataattccaagtcac	5	9	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:88883148A>G	uc001xwq.2	+	5	483	c.332A>G	c.(331-333)TAT>TGT	p.Y111C	SPATA7_uc001xwr.2_Missense_Mutation_p.Y79C|SPATA7_uc001xws.2_Missense_Mutation_p.Y47C|SPATA7_uc001xwt.2_Missense_Mutation_p.Y5C	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	111					response to stimulus|visual perception					ovary(1)	1						CGAGCCAATTATAAAAATAAT	0.294													0	0	0	0.004482	0	7	76										G	88883148	A	G	88883148	3	3	20	1	0	0	0	0	1	0	0	0	15013	449	16	5	350	5	SPATA7	14	88883148	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	6932451	88883148	18466392	294	5998										
ZC3H14	79882	broad.mit.edu	37	chr14	89044449	89044449	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aagtccccccattaaagaagAggaaacaaaaggagattctg	9	8	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:89044449A>G	uc001xww.2	+	9	1469	c.1244A>G	c.(1243-1245)GAG>GGG	p.E415G	ZC3H14_uc010twd.1_Missense_Mutation_p.E415G|ZC3H14_uc010twe.1_Missense_Mutation_p.E415G|ZC3H14_uc001xwx.2_Missense_Mutation_p.E415G|ZC3H14_uc010twf.1_Missense_Mutation_p.E260G|ZC3H14_uc001xwy.2_Missense_Mutation_p.E381G|ZC3H14_uc010twg.1_Missense_Mutation_p.E260G|ZC3H14_uc001xxa.2_5'UTR	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	415						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						ATTAAAGAAGAGGAAACAAAA	0.388													0	0	0	0.00308	0	6	107										G	89044449	A	G	89044449	3	3	20	1	0	0	0	0	1	0	0	0	17563	304	11	5	1278	5	ZC3H14	14	89044449	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	161301	89044449	18305091	295	5999										
PAPOLA	10914	broad.mit.edu	37	chr14	96998956	96998956	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgcaatagcatcaactcttgTacataaatttttcttggtat	5	7	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:96998956T>C	uc001yfq.2	+	9	1016	c.806T>C	c.(805-807)GTA>GCA	p.V269A	PAPOLA_uc001yfp.2_Missense_Mutation_p.V269A|PAPOLA_uc001yfr.2_Missense_Mutation_p.V269A|PAPOLA_uc010twv.1_Missense_Mutation_p.V269A|PAPOLA_uc010avp.2_Missense_Mutation_p.V19A	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	269					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		TCAACTCTTGTACATAAATTT	0.313													0	0	0	0.001984	0	5	61										C	96998956	T	C	96998956	3	2	20	1	0	0	0	0	1	0	0	0	11429	1638	57	5	840	5	PAPOLA	14	96998956	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	7954507	96998956	10350584	296	6000										
TECPR2	9895	broad.mit.edu	37	chr14	102904529	102904529	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gatgctgtccagcaggtggcAgtctcgccctcaggttcgcc	13	14	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:102904529A>G	uc001ylw.1	+	10	2713	c.2565A>G	c.(2563-2565)GCA>GCG	p.A855A	TECPR2_uc010awl.2_Silent_p.A855A|TECPR2_uc010txx.1_Silent_p.A18A	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	855							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						AGCAGGTGGCAGTCTCGCCCT	0.438											OREG0022547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	9	54										G	102904529	A	G	102904529	2	3	20	1	0	0	0	0	0	0	0	1	15741	175	7	5		5	TECPR2	14	102904529	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	5905573	102904529	4445011	297	6001										
AMN	81693	broad.mit.edu	37	chr14	103390133	103390133	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agccagaaccggaccccgtgCgccggcggcgccgttgagtt	15	15	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr14:103390133C>A	uc001ymg.3	+	2	162	c.129C>A	c.(127-129)TGC>TGA	p.C43*	AMN_uc001ymh.3_5'UTR	NM_030943	NP_112205	Q9BXJ7	AMNLS_HUMAN	amnionless protein precursor	43	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|multicellular organismal development	integral to membrane|plasma membrane					0				Colorectal(3;0.00739)|READ - Rectum adenocarcinoma(2;0.0336)|Epithelial(152;0.0363)|all cancers(159;0.147)	Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGACCCCGTGCGCCGGCGGCG	0.716													1	0	2.17888e-05	0.006214	2.25829e-05	10	48										A	103390133	C	A	103390133	4	1	20	1	0	0	0	0	0	1	0	0	580	776	27	4	135	4	AMN	14	103390133	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	485604	103390133	3959407	298	6002										
CYFIP1	23191	broad.mit.edu	37	chr15	23003016	23003016	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgctgcttccagccgcccatCcaccagtccctcgccagcag	8	21	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:23003016C>G	uc001yus.2	+	31	3842	c.3738C>G	c.(3736-3738)ATC>ATG	p.I1246M	CYFIP1_uc001yut.2_Missense_Mutation_p.I1246M|CYFIP1_uc001yuu.2_Missense_Mutation_p.I815M|CYFIP1_uc001yuv.2_Missense_Mutation_p.I440M	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	1246					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		AGCCGCCCATCCACCAGTCCC	0.552													0	0	0	0.000602	0	5	38										G	23003016	C	G	23003016	3	3	20	1	0	0	0	0	1	0	0	0	4137	845	30	1	4237	1	CYFIP1	15	23003016	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		23003016	79528376	299	6003										
C15orf55	256646	broad.mit.edu	37	chr15	34640674	34640674	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcaactggtccccattgtgcCcctggaaaaagcttggccag	10	13	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:34640674C>T	uc001zif.2	+	2	676	c.521C>T	c.(520-522)CCC>CTC	p.P174L	C15orf55_uc010ucc.1_Missense_Mutation_p.P202L|C15orf55_uc010ucd.1_Missense_Mutation_p.P192L	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	174	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCCATTGTGCCCCTGGAAAAA	0.597			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.004672	0	3	26										T	34640674	C	T	34640674	3	4	20	1	0	0	0	0	1	0	0	0	1803	623	22	2	527	2	C15orf55	15	34640674	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	11637658	34640674	67890718	300	6004										
ZNF770	54989	broad.mit.edu	37	chr15	35275416	35275416	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggcagactatgagttagttGatgcctctccagatgaacta	10	8	1	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:35275416G>A	uc001ziw.2	-	3	531	c.220C>T	c.(220-222)CAA>TAA	p.Q74*		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	74	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TGAGTTAGTTGATGCCTCTCC	0.358													0	0	0	0.003163	0	12	84										A	35275416	G	A	35275416	4	1	20	1	0	0	0	0	0	1	0	0	18140	1299	45	1	1859	1	ZNF770	15	35275416	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	634742	35275416	67255976	301	6005										
CASC5	57082	broad.mit.edu	37	chr15	40917631	40917631	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cctgtatatcctgatgagatCaattcttcagactctattaa	5	9	4	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:40917631C>T	uc010bbs.1	+	11	5408	c.5247C>T	c.(5245-5247)ATC>ATT	p.I1749I	CASC5_uc010ucq.1_Silent_p.I1573I|CASC5_uc001zme.2_Silent_p.I1723I|CASC5_uc010bbt.1_Silent_p.I1723I	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1749					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CTGATGAGATCAATTCTTCAG	0.343													0	0	0	0.004007	0	15	114										T	40917631	C	T	40917631	2	4	20	1	0	0	0	0	0	0	0	1	2663	816	29	1		1	CASC5	15	40917631	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5642215	40917631	61613761	302	6006										
INO80	54617	broad.mit.edu	37	chr15	41347486	41347486	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttcggcatggctctcaatgTccttggaaaaccattcatta	7	10	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:41347486T>A	uc001zni.2	-	18	2360	c.2147A>T	c.(2146-2148)GAC>GTC	p.D716V	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	716	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						GCTCTCAATGTCCTTGGAAAA	0.378													0	0	0	0.00499	0	16	76										A	41347486	T	A	41347486	3	1	20	1	0	0	0	0	1	0	0	0	7746	1667	58	5	2599	5	INO80	15	41347486	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	429855	41347486	61183906	303	6007										
EXD1	161829	broad.mit.edu	37	chr15	41482170	41482170	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccggtctgcagacccttcgcGatacgtgtttaggtaaccat	10	12	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:41482170G>T	uc001znk.2	-	9	1038	c.847C>A	c.(847-849)CGC>AGC	p.R283S	EXD1_uc001znj.2_Missense_Mutation_p.R81S|EXD1_uc010ucv.1_Missense_Mutation_p.R341S	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	283					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						GACCCTTCGCGATACGTGTTT	0.547													1	0	2.17888e-05	0.006214	2.25829e-05	7	132										T	41482170	G	T	41482170	3	4	20	1	0	0	0	0	1	0	0	0	5297	1058	37	3	705	3	EXD1	15	41482170	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	134684	41482170	61049222	304	6008										
SPTBN5	51332	broad.mit.edu	37	chr15	42171661	42171661	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acactgtgtgccagctgcacGgccttctccctcttcagggc	10	16	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:42171661G>C	uc001zos.2	-	16	3207	c.2874C>G	c.(2872-2874)GCC>GCG	p.A958A		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	993	Spectrin 7.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCAGCTGCACGGCCTTCTCCC	0.632													0	0	0	0.009096	0	4	6										C	42171661	G	C	42171661	2	2	20	1	0	0	0	0	0	0	0	1	15121	1103	39	4		4	SPTBN5	15	42171661	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	689491	42171661	60359731	305	6009										
FBN1	2200	broad.mit.edu	37	chr15	48725087	48725087	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcacatcctacggtcttctcTgagcacatatcccacgggac	8	15	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:48725087T>C	uc001zwx.1	-	55	7043	c.6715A>G	c.(6715-6717)AGA>GGA	p.R2239G	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2239	EGF-like 38; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CGGTCTTCTCTGAGCACATAT	0.468													0	0	0	0.007835	0	30	171										C	48725087	T	C	48725087	3	2	20	1	0	0	0	0	1	0	0	0	5702	1588	55	5	1948	5	FBN1	15	48725087	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	6553426	48725087	53806305	306	6010										
FBN1	2200	broad.mit.edu	37	chr15	48773879	48773879	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gccagtttttccttttttgcCggagtagcccatatcacagt	8	11	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:48773879C>G	uc001zwx.1	-	32	4265	c.3937G>C	c.(3937-3939)GGC>CGC	p.G1313R		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1313	EGF-like 21; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCTTTTTTGCCGGAGTAGCCC	0.373													0	0	0	0.00499	0	14	137										G	48773879	C	G	48773879	3	3	20	1	0	0	0	0	1	0	0	0	5702	652	23	4	4818	4	FBN1	15	48773879	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	48792	48773879	53757513	307	6011										
CYP19A1	1588	broad.mit.edu	37	chr15	51514603	51514603	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtccagcatgacacgacgcaGaagggtcaacacgtccacat	10	13	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:51514603G>A	uc001zyz.3	-	6	822	c.571C>T	c.(571-573)CTG>TTG	p.L191L	CYP19A1_uc001zza.3_Silent_p.L191L|CYP19A1_uc001zzb.2_Silent_p.L191L|CYP19A1_uc001zzd.2_Silent_p.L191L|CYP19A1_uc010bey.1_Silent_p.L191L	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	191					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	ACACGACGCAGAAGGGTCAAC	0.488													0	0	0	0.006214	0	8	96										A	51514603	G	A	51514603	2	1	20	1	0	0	0	0	0	0	0	1	4148	933	33	1		1	CYP19A1	15	51514603	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2740724	51514603	51016789	308	6012										
DMXL2	23312	broad.mit.edu	37	chr15	51792343	51792343	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcttccatacaacatttccaGaagcgtactttattgtcaga	6	10	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:51792343G>C	uc002abf.2	-	18	3303	c.3078C>G	c.(3076-3078)TTC>TTG	p.F1026L	DMXL2_uc010ufy.1_Missense_Mutation_p.F1026L|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1026	WD 8.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		AACATTTCCAGAAGCGTACTT	0.363													0	0	0	0.001168	0	5	108										C	51792343	G	C	51792343	3	2	20	1	0	0	0	0	1	0	0	0	4595	933	33	1	6139	1	DMXL2	15	51792343	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	277740	51792343	50739049	309	6013										
LIPC	3990	broad.mit.edu	37	chr15	58855759	58855759	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcttatcacgctggatgtgGatatcggcgagctgatcatg	12	8	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:58855759G>C	uc010bga.1	+	10	1833	c.1225G>C	c.(1225-1227)GAT>CAT	p.D409H	LIPC_uc010bfz.1_Missense_Mutation_p.D409H|LIPC_uc002afa.1_Missense_Mutation_p.D409H|LIPC_uc010bgb.1_Missense_Mutation_p.D307H|LIPC_uc010ugy.1_Missense_Mutation_p.D348H	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	409	PLAT.		D -> A.		cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		GCTGGATGTGGATATCGGCGA	0.453													0	0	0	0.006214	0	9	176										C	58855759	G	C	58855759	3	2	20	1	0	0	0	0	1	0	0	0	8820	1174	41	1	1255	1	LIPC	15	58855759	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	7063416	58855759	43675633	310	6014										
VPS13C	54832	broad.mit.edu	37	chr15	62167121	62167121	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	actccaatcactaacccctcTgcaaattcttcagggccttg	5	15	4	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:62167121T>C	uc002agz.2	-	77	10442	c.10368A>G	c.(10366-10368)GCA>GCG	p.A3456A	VPS13C_uc002aha.2_Silent_p.A3413A|VPS13C_uc002ahb.1_Silent_p.A3456A|VPS13C_uc002ahc.1_Silent_p.A3413A	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3456					protein localization					ovary(2)	2						CTAACCCCTCTGCAAATTCTT	0.294													0	0	0	0.01441	0	45	220										C	62167121	T	C	62167121	2	2	20	1	0	0	0	0	0	0	0	1	17188	1567	55	5		5	VPS13C	15	62167121	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	3311362	62167121	40364271	311	6015										
TLN2	83660	broad.mit.edu	37	chr15	63032843	63032843	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttccagacaaaagaagaccaGatccaagtgatagggaacct	9	9	0	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:63032843G>C	uc002alb.3	+	29	3900	c.3900G>C	c.(3898-3900)CAG>CAC	p.Q1300H	TLN2_uc002alc.3_5'UTR	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1300					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AAGAAGACCAGATCCAAGTGA	0.502													0	0	0	0.010504	0	21	101										C	63032843	G	C	63032843	3	2	20	1	0	0	0	0	1	0	0	0	15945	933	33	1	4014	1	TLN2	15	63032843	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	865722	63032843	39498549	312	6016										
DENND4A	10260	broad.mit.edu	37	chr15	66021464	66021464	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgacatctggtggaggatcaTagagatcaaagtatcttgaa	11	5	4	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:66021464T>C	uc002aph.2	-	11	1811	c.1433A>G	c.(1432-1434)TAT>TGT	p.Y478C	DENND4A_uc002api.2_Missense_Mutation_p.Y478C|DENND4A_uc002apj.3_Missense_Mutation_p.Y478C|DENND4A_uc010ujj.1_Missense_Mutation_p.Y478C	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	478	DENN.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGGAGGATCATAGAGATCAAA	0.393													0	0	0	0.00308	0	5	19										C	66021464	T	C	66021464	3	2	20	1	0	0	0	0	1	0	0	0	4433	1406	49	5	4379	5	DENND4A	15	66021464	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	2988621	66021464	36509928	313	6017										
RAB11A	8766	broad.mit.edu	37	chr15	66172008	66172008	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aacttttgtgtctcccctcaGaaaagaatggtttgtcattc	7	9	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:66172008G>A	uc002apk.2	+	4	559	c.431_splice	c.e4-1	p.E144_splice	RAB11A_uc010ujk.1_Splice_Site_p.E144_splice	NM_004663	NP_004654	P62491	RB11A_HUMAN	Ras-related protein Rab-11A						cell cycle|cytokinesis|neuron projection development|plasma membrane to endosome transport|protein localization in plasma membrane|small GTPase mediated signal transduction|vesicle-mediated transport	cleavage furrow|plasma membrane|recycling endosome membrane|trans-Golgi network	GTP binding|GTPase activity|syntaxin binding				0						TCTCCCCTCAGAAAAGAATGG	0.338													0	0	0	0.008291	0	10	155										A	66172008	G	A	66172008	5	1	20	1	0	0	0	0	0	0	1	0	12891	956	33	1	444	1	RAB11A	15	66172008	Splice_Site	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	150544	66172008	36359384	314	6018										
ACSBG1	23205	broad.mit.edu	37	chr15	78475048	78475048	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agggccccactgcccataccGtgtacacattggccatcttg	9	15	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:78475048G>A	uc002bdh.2	-	6	799	c.743C>T	c.(742-744)ACG>ATG	p.T248M	ACSBG1_uc010umw.1_Missense_Mutation_p.T244M|ACSBG1_uc010umx.1_Missense_Mutation_p.T6M|ACSBG1_uc010umy.1_Missense_Mutation_p.T141M	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	248					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						TGCCCATACCGTGTACACATT	0.537													0	0	0	0.004289	0	27	161										A	78475048	G	A	78475048	3	1	20	1	0	0	0	0	1	0	0	0	173	1159	40	2	1467	2	ACSBG1	15	78475048	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	12303040	78475048	24056344	315	6019										
FAM154B	283726	broad.mit.edu	37	chr15	82575106	82575106	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agttgtcgtcaaggacttatTaagaagcagcagcagattcc	10	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:82575106T>C	uc002bgv.2	+	3	969	c.900T>C	c.(898-900)ATT>ATC	p.I300I	FAM154B_uc010unr.1_Silent_p.I285I|FAM154B_uc010uns.1_RNA	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	hypothetical protein LOC283726	300										skin(2)	2						AAGGACTTATTAAGAAGCAGC	0.398													0	0	0	0.014323	0	16	74										C	82575106	T	C	82575106	2	2	20	1	0	0	0	0	0	0	0	1	5464	1742	61	5		5	FAM154B	15	82575106	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	4100058	82575106	19956286	316	6020										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651116	84651116	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	attcagacaagggaagagaaGcgtattaacctgaccattgg	11	7	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:84651116G>T	uc002bjz.3	+	21	2960	c.2736G>T	c.(2734-2736)AAG>AAT	p.K912N	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.K912N|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.K912N	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	912	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGAAGAGAAGCGTATTAACC	0.468													1	0	0.000157383	0.00308	0.000161646	8	99										T	84651116	G	T	84651116	3	4	20	1	0	0	0	0	1	0	0	0	276	962	34	4	2814	4	ADAMTSL3	15	84651116	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2076010	84651116	17880276	317	6021										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651605	84651605	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agcaccaactcctgggagttGaagaataagcagtttgaagc	11	8	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:84651605G>A	uc002bjz.3	+	21	3449	c.3225G>A	c.(3223-3225)TTG>TTA	p.L1075L	ADAMTSL3_uc010bmt.1_Silent_p.L1075L|ADAMTSL3_uc010bmu.1_Silent_p.L1075L	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1075						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCTGGGAGTTGAAGAATAAGC	0.443													0	0	0	0.001168	0	6	72										A	84651605	G	A	84651605	2	1	20	1	0	0	0	0	0	0	0	1	276	1281	45	1		1	ADAMTSL3	15	84651605	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	489	84651605	17879787	318	6022										
AGBL1	123624	broad.mit.edu	37	chr15	86702233	86702233	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	caaggttattactccttacaCccgaaagcgcacccaagcaa	6	14	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:86702233C>A	uc002blz.1	+	4	406	c.326C>A	c.(325-327)ACC>AAC	p.T109N		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	109					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ACTCCTTACACCCGAAAGCGC	0.438													1	0	5.61819e-17	0.005443	6.28078e-17	18	117										A	86702233	C	A	86702233	3	1	20	1	0	0	0	0	1	0	0	0	375	507	18	4	336	4	AGBL1	15	86702233	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2050628	86702233	15829159	319	6023										
NTRK3	4916	broad.mit.edu	37	chr15	88679230	88679230	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcactcgtcacattcaccagCgtcaagttgatggcatgaac	8	12	4	2	rs141317844	by1000genomes	TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:88679230C>G	uc002bme.1	-	8	969	c.807G>C	c.(805-807)ACG>ACC	p.T269T	NTRK3_uc002bmh.2_Silent_p.T269T|NTRK3_uc002bmf.1_Silent_p.T269T|NTRK3_uc010upl.1_Silent_p.T171T|NTRK3_uc010bnh.1_Silent_p.T269T|NTRK3_uc002bmg.2_Silent_p.T269T	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	269	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CATTCACCAGCGTCAAGTTGA	0.478			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.008871	0	16	154										G	88679230	C	G	88679230	2	3	20	1	0	0	0	0	0	0	0	1	10708	755	27	4		4	NTRK3	15	88679230	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1976997	88679230	13852162	320	6024										
CRTC3	64784	broad.mit.edu	37	chr15	91169176	91169176	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgagtgtggggaatagtgtGaacaacatcccagctgctat	12	7	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:91169176G>A	uc002bpp.2	+	10	1024	c.918G>A	c.(916-918)GTG>GTA	p.V306V	CRTC3_uc002bpo.2_Silent_p.V306V	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	306					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			GGAATAGTGTGAACAACATCC	0.537			T	MAML2	salivary gland mucoepidermoid								0	0	0	0.00874	0	34	500										A	91169176	G	A	91169176	2	1	20	1	0	0	0	0	0	0	0	1	3901	1277	45	1		1	CRTC3	15	91169176	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2489946	91169176	11362216	321	6025										
CHD2	1106	broad.mit.edu	37	chr15	93496669	93496669	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcctctcctacctgttccacCaacaccagctgtatggcccc	5	19	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr15:93496669C>A	uc002bsp.2	+	14	2160	c.1585C>A	c.(1585-1587)CAA>AAA	p.Q529K	CHD2_uc002bso.1_Missense_Mutation_p.Q529K	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	529	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCTGTTCCACCAACACCAGCT	0.443													1	0	9.86323e-18	0.003954	1.10536e-17	24	108										A	93496669	C	A	93496669	3	1	20	1	0	0	0	0	1	0	0	0	3325	595	21	4	1639	4	CHD2	15	93496669	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2327493	93496669	9034723	322	6026										
ZNF213	7760	broad.mit.edu	37	chr16	3189016	3189016	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	catcccattctatttctcccGggaagaatggggcaccctgg	10	13	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:3189016G>C	uc010uws.1	+	5	1085	c.638G>C	c.(637-639)CGG>CCG	p.R213P	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Missense_Mutation_p.R213P|ZNF213_uc010uwt.1_Silent_p.P188P	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	213	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TATTTCTCCCGGGAAGAATGG	0.617													0	0	0	0.013537	0	9	170										C	3189016	G	C	3189016	3	2	20	1	0	0	0	0	1	0	0	0	17766	1116	39	4	652	4	ZNF213	16	3189016	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08		3189016	87165737	323	6027										
ATF7IP2	80063	broad.mit.edu	37	chr16	10524885	10524885	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcacagaagaggcaaaagaTtcactgaacacttctgaaaa	7	8	3	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:10524885T>G	uc002czu.2	+	3	635	c.408T>G	c.(406-408)GAT>GAG	p.D136E	ATF7IP2_uc002czv.2_Missense_Mutation_p.D136E|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Intron|ATF7IP2_uc002czw.2_Missense_Mutation_p.D136E|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGGCAAAAGATTCACTGAACA	0.413													0	0	0	0.003271	0	27	103										G	10524885	T	G	10524885	3	3	20	1	0	0	0	0	1	0	0	0	1088	1490	52	5	410	5	ATF7IP2	16	10524885	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	7335869	10524885	79829868	324	6028										
KIAA0430	9665	broad.mit.edu	37	chr16	15728731	15728731	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aagaggtgcaggttgagtatTtggaggtggtatatttggcc	16	3	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:15728731T>A	uc002ddr.2	-	4	1082	c.889A>T	c.(889-891)AAT>TAT	p.N297Y	KIAA0430_uc002ddq.2_Missense_Mutation_p.N296Y|KIAA0430_uc010uzv.1_Missense_Mutation_p.N296Y|KIAA0430_uc010uzw.1_Missense_Mutation_p.N296Y|KIAA0430_uc010uzx.1_3'UTR	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	296						peroxisome	nucleotide binding|RNA binding				0						GGTTGAGTATTTGGAGGTGGT	0.443													0	0	0	0.00308	0	7	174										A	15728731	T	A	15728731	3	1	20	1	0	0	0	0	1	0	0	0	8177	1841	64	5	4438	5	KIAA0430	16	15728731	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	5203846	15728731	74626022	325	6029										
DNAH3	55567	broad.mit.edu	37	chr16	20975225	20975225	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtcaaggaatgcatgtagagAtttatgaaccaagtcaggga	12	5	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:20975225A>G	uc010vbe.1	-	53	9981	c.9981T>C	c.(9979-9981)AAT>AAC	p.N3327N	DNAH3_uc010vbd.1_Silent_p.N762N	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3327					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCATGTAGAGATTTATGAACC	0.488													0	0	0	0.010729	0	10	127										G	20975225	A	G	20975225	2	3	20	1	0	0	0	0	0	0	0	1	4603	330	12	5		5	DNAH3	16	20975225	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	5246494	20975225	69379528	326	6030										
CRYM	1428	broad.mit.edu	37	chr16	21273477	21273477	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtcaggtctgctggctccaaCagctaagagacagcaaaaca	10	11	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:21273477C>G	uc002dik.2	-	6	761	c.676G>C	c.(676-678)GTT>CTT	p.V226L	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Missense_Mutation_p.V184L|CRYM_uc002dim.2_Missense_Mutation_p.V226L	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	226					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	CTGGCTCCAACAGCTAAGAGA	0.522													0	0	0	0.001984	0	5	40										G	21273477	C	G	21273477	3	3	20	1	0	0	0	0	1	0	0	0	3921	478	17	4	280	4	CRYM	16	21273477	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	298252	21273477	69081276	327	6031										
PDZD9	255762	broad.mit.edu	37	chr16	21995741	21995750	+	Frame_Shift_Del	DEL	TTTCTTGTCG	TTTCTTGTCG	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggagaaggggccctcacttcTttcttgtcgtctctgtgaat					rs146108684	byFrequency	TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:21995741_21995750delTTTCTTGTCG	uc002dka.1	-	5	764_773	c.447_456delCGACAAGAAA	c.(445-456)GACGACAAGAAAfs	p.D149fs		NM_173806	NP_776167	Q8IXQ8	PDZD9_HUMAN	hypothetical protein LOC255762	211_214										pancreas(1)	1						CCCTCACTTCTTTCTTGTCGTCTCTGTGAA	0.433																		13	219	---	---								-	21995750	TTTCTTGTCG	-	21995741	7	5	20	1	0	1	0	1	0	0	0	0	11706	1606	56	0	156	0	PDZD9	16	21995741	Frame_Shift_Del	DEL	TTTCTTGTCG	TCGA-BT-A3PK-01A-21D-A21Z-08	722264	21995741	68359012	328	6032										
RABEP2	79874	broad.mit.edu	37	chr16	28919983	28919983	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctgctcctgctgcgagccctGgggggctgaggatggcagct	17	12	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:28919983G>A	uc002drq.2	-	8	1240	c.1192C>T	c.(1192-1194)CAG>TAG	p.Q398*	uc010vct.1_Intron|RABEP2_uc010vdf.1_Nonsense_Mutation_p.Q327*|RABEP2_uc010byn.2_Nonsense_Mutation_p.Q366*	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	398	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						TGCGAGCCCTGGGGGGCTGAG	0.642													0	0	0	0.008871	0	19	191										A	28919983	G	A	28919983	4	1	20	1	0	0	0	0	0	1	0	0	12962	1357	47	2	541	2	RABEP2	16	28919983	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	6924242	28919983	61434770	329	6033										
CD2BP2	10421	broad.mit.edu	37	chr16	30365608	30365608	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgtttgcctttaaagcggctCccaggaccccctgacccagc	9	16	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:30365608C>T	uc002dxr.2	-	2	367	c.114G>A	c.(112-114)GGG>GGA	p.G38G	CD2BP2_uc002dxs.2_Silent_p.G38G	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	38					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						TAAAGCGGCTCCCAGGACCCC	0.537													0	0	0	0.010818	0	25	362										T	30365608	C	T	30365608	2	4	20	1	0	0	0	0	0	0	0	1	2995	842	30	1		1	CD2BP2	16	30365608	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1445625	30365608	59989145	330	6034										
RPGRIP1L	23322	broad.mit.edu	37	chr16	53636095	53636095	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttcaccatctgctcgtgcatCaaaaactagggagaaaagag	9	9	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:53636095C>G	uc002ehp.2	-	27	3905	c.3841G>C	c.(3841-3843)GAT>CAT	p.D1281H	RPGRIP1L_uc002eho.3_Missense_Mutation_p.D1201H|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.D1235H|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.D1247H	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	1281					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				GCTCGTGCATCAAAAACTAGG	0.423													0	0	0	0.00308	0	5	56										G	53636095	C	G	53636095	3	3	20	1	0	0	0	0	1	0	0	0	13550	826	29	1	110	1	RPGRIP1L	16	53636095	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	23270487	53636095	36718658	331	6035										
IRX6	79190	broad.mit.edu	37	chr16	55360337	55360337	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcaggctccaccccagcgccCgctctctgctgcgcacccta	8	21	2	0	rs139857215	byFrequency	TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:55360337C>G	uc002ehy.2	+	2	668	c.135C>G	c.(133-135)CCC>CCG	p.P45P	IRX6_uc002ehx.2_Silent_p.P45P|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	45						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CCCCAGCGCCCGCTCTCTGCT	0.637													0	0	0	0.006214	0	7	61										G	55360337	C	G	55360337	2	3	20	1	0	0	0	0	0	0	0	1	7848	639	23	4		4	IRX6	16	55360337	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1724242	55360337	34994416	332	6036										
IRX6	79190	broad.mit.edu	37	chr16	55362966	55362966	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtctctggcgcacaccgcgaCagccagcgctgttgaaggtg	14	13	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:55362966C>T	uc002ehy.2	+	5	1609	c.1076C>T	c.(1075-1077)ACA>ATA	p.T359I	IRX6_uc002ehx.2_Missense_Mutation_p.T359I	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	359						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						CACACCGCGACAGCCAGCGCT	0.637													0	0	0	0.008871	0	14	104										T	55362966	C	T	55362966	3	4	20	1	0	0	0	0	1	0	0	0	7848	478	17	2	1094	2	IRX6	16	55362966	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2629	55362966	34991787	333	6037										
NLRC5	84166	broad.mit.edu	37	chr16	57103764	57103764	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccaggctgacctccagctgtGtgagcaccgagggcctcgcc	13	16	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:57103764G>T	uc002ekk.1	+	37	4741	c.4516G>T	c.(4516-4518)GTG>TTG	p.V1506L	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Missense_Mutation_p.V48L|NLRC5_uc002ekr.1_Missense_Mutation_p.V393L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1506	LRR 16.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CTCCAGCTGTGTGAGCACCGA	0.637													1	0	0.000274275	0.004482	0.00028107	5	20										T	57103764	G	T	57103764	3	4	20	1	0	0	0	0	1	0	0	0	10470	1377	48	4	4654	4	NLRC5	16	57103764	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1740798	57103764	33250989	334	6038										
FAM65A	79567	broad.mit.edu	37	chr16	67576933	67576933	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccagatccctcagagtctacGgttcagagtctaagccccac	8	15	4	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr16:67576933G>T	uc010vjp.1	+	13	2400	c.2304G>T	c.(2302-2304)ACG>ACT	p.T768T	FAM65A_uc010cei.1_Silent_p.T590T|FAM65A_uc002eth.2_Silent_p.T748T|FAM65A_uc010cej.2_Silent_p.T751T|FAM65A_uc002eti.1_Silent_p.T711T|FAM65A_uc010vjq.1_Silent_p.T762T|FAM65A_uc002etj.1_Silent_p.T747T|FAM65A_uc002etk.2_Silent_p.T747T	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	752	Pro-rich.					cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CAGAGTCTACGGTTCAGAGTC	0.622													1	0	3.4597e-24	0.01441	3.95519e-24	48	187										T	67576933	G	T	67576933	2	4	20	1	0	0	0	0	0	0	0	1	5599	1103	39	4		4	FAM65A	16	67576933	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	10473169	67576933	22777820	335	6039										
SRR	63826	broad.mit.edu	37	chr17	2221250	2221250	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttgttactcacagcagtggAaaccatggccaggctctcac	10	12	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:2221250A>C	uc002fue.1	+	3	323	c.255A>C	c.(253-255)GGA>GGC	p.G85G	SRR_uc002fui.1_5'UTR|SRR_uc002fuh.1_Silent_p.G85G	NM_021947	NP_068766	Q9GZT4	SRR_HUMAN	serine racemase	85					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity				0		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACAGCAGTGGAAACCATGGCC	0.468													0	0	0	0.014323	0	22	104										C	2221250	A	C	2221250	2	2	20	1	0	0	0	0	0	0	0	1	15165	233	9	5		5	SRR	17	2221250	Silent	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08		2221250	78973960	336	6040										
PSMB6	5694	broad.mit.edu	37	chr17	4700748	4700748	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgcaggtcctacatcgccaaTcgagtgactgacaagctgac	10	12	0	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:4700748T>A	uc002fzb.2	+	3	219	c.186T>A	c.(184-186)AAT>AAA	p.N62K		NM_002798	NP_002789	P28072	PSB6_HUMAN	proteasome beta 6 subunit precursor	62					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2						ACATCGCCAATCGAGTGACTG	0.552													0	0	0	0.009535	0	25	130										A	4700748	T	A	4700748	3	1	20	1	0	0	0	0	1	0	0	0	12681	1432	50	5	196	5	PSMB6	17	4700748	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	2479498	4700748	76494462	337	6041										
RICH2	9912	broad.mit.edu	37	chr17	12888211	12888211	+	Frame_Shift_Del	DEL	A	A	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agatggcatgtcccctggggAaagcatgtctacaggtaacc							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:12888211delA	uc002gnr.3	+	20	2630	c.2303delA	c.(2302-2304)GAAfs	p.E768fs	RICH2_uc010vvk.1_Frame_Shift_Del_p.E768fs|RICH2_uc010vvl.1_Frame_Shift_Del_p.E762fs|RICH2_uc002gns.3_Frame_Shift_Del_p.E562fs|RICH2_uc010vvm.1_Frame_Shift_Del_p.E762fs|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	768					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TCCCCTGGGGAAAGCATGTCT	0.537																		11	58	---	---								-	12888211	A	-	12888211	7	5	20	1	0	1	0	1	0	0	0	0	13357	246	9	0	2381	0	RICH2	17	12888211	Frame_Shift_Del	DEL	A	TCGA-BT-A3PK-01A-21D-A21Z-08	8187463	12888211	68306999	338	6042										
NCOR1	9611	broad.mit.edu	37	chr17	15952254	15952254	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tggggtggggagatgggctcGtagggctccgaagagacgtg	21	6	0	2	rs144480346	byFrequency	TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:15952254G>C	uc002gpo.2	-	41	6681	c.6441C>G	c.(6439-6441)TAC>TAG	p.Y2147*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.Y2044*|NCOR1_uc002gpl.2_Nonsense_Mutation_p.Y162*|NCOR1_uc002gpm.2_Nonsense_Mutation_p.Y667*|NCOR1_uc010vwb.1_Nonsense_Mutation_p.Y731*|NCOR1_uc010coy.2_Nonsense_Mutation_p.Y1055*|NCOR1_uc010vwc.1_Nonsense_Mutation_p.Y957*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2147	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGATGGGCTCGTAGGGCTCCG	0.522													0	0	0	0.014323	0	18	102										C	15952254	G	C	15952254	4	2	20	1	0	0	0	0	0	1	0	0	10235	1140	40	4	905	4	NCOR1	17	15952254	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3064043	15952254	65242956	339	6043										
MAPK7	5598	broad.mit.edu	37	chr17	19284405	19284405	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctgtgggggctgagagggtgCgggcctatatccagagcttg	18	8	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:19284405C>A	uc002gvn.2	+	4	1269	c.883C>A	c.(883-885)CGG>AGG	p.R295R	B9D1_uc010cqm.1_5'Flank|B9D1_uc002gvl.3_5'Flank|MAPK7_uc002gvo.2_Silent_p.R156R|MAPK7_uc002gvq.2_Silent_p.R295R|MAPK7_uc002gvp.2_Silent_p.R295R	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	295	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					TGAGAGGGTGCGGGCCTATAT	0.607													1	0	4.68919e-08	0.008291	4.99668e-08	8	68										A	19284405	C	A	19284405	2	1	20	1	0	0	0	0	0	0	0	1	9282	759	27	4		4	MAPK7	17	19284405	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3332151	19284405	61910805	340	6044										
SLFN12L	342615	broad.mit.edu	37	chr17	33806548	33806548	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgtaacaacttttcagtcgaGaagttttttatttcaacgtg	7	6	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:33806548G>C	uc002hjn.2	-	3	1647	c.768C>G	c.(766-768)TTC>TTG	p.F256L		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TTTCAGTCGAGAAGTTTTTTA	0.343													0	0	0	0.001168	0	5	65										C	33806548	G	C	33806548	3	2	20	1	0	0	0	0	1	0	0	0	14735	933	33	1	1097	1	SLFN12L	17	33806548	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	14522143	33806548	47388662	341	6045										
RAPGEFL1	51195	broad.mit.edu	37	chr17	38346912	38346912	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtgcccctccccgaggagatCcaggtctcccctggagacac	11	17	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:38346912C>T	uc010cwu.1	+	8	1105	c.615C>T	c.(613-615)ATC>ATT	p.I205I	RAPGEFL1_uc010wfd.1_Silent_p.I141I	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	411					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CCGAGGAGATCCAGGTCTCCC	0.637													0	0	0	0.009718	0	40	146										T	38346912	C	T	38346912	2	4	20	1	0	0	0	0	0	0	0	1	13049	845	30	1		1	RAPGEFL1	17	38346912	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	4540364	38346912	42848298	342	6046										
ITGA2B	3674	broad.mit.edu	37	chr17	42462686	42462686	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggagctgaagcccgcttcacAgtaacgcttgtcccagcctg	11	14	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:42462686A>T	uc002igt.1	-	5	624	c.592T>A	c.(592-594)TGT>AGT	p.C198S		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	198	FG-GAP 3.|Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CCCGCTTCACAGTAACGCTTG	0.682													0	0	0	0.009096	0	3	27										T	42462686	A	T	42462686	3	4	20	1	0	0	0	0	1	0	0	0	7876	188	7	5	2631	5	ITGA2B	17	42462686	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	4115774	42462686	38732524	343	6047										
OSBPL7	114881	broad.mit.edu	37	chr17	45891068	45891068	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgttgagctgcacaggcattGacaccttggacaggtctttg	12	10	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:45891068G>A	uc002ilx.1	-	15	1687	c.1484C>T	c.(1483-1485)TCA>TTA	p.S495L	OSBPL7_uc002ilw.1_Missense_Mutation_p.S57L	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	495					lipid transport		lipid binding				0						CACAGGCATTGACACCTTGGA	0.662													0	0	0	0.00308	0	7	83										A	45891068	G	A	45891068	3	1	20	1	0	0	0	0	1	0	0	0	11282	1294	45	1	1080	1	OSBPL7	17	45891068	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3428382	45891068	35304142	344	6048										
SLC35B1	10237	broad.mit.edu	37	chr17	47784399	47784399	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggcaaaggtgaacgtctcctGcttggctccttccccatact	9	14	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:47784399G>T	uc002iph.1	-	2	223	c.136C>A	c.(136-138)CAG>AAG	p.Q46K	SLC35B1_uc002ipi.1_5'UTR|SLC35B1_uc002ipj.1_5'UTR|SLC35B1_uc010wly.1_Missense_Mutation_p.Q46K	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	46						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						AACGTCTCCTGCTTGGCTCCT	0.403													1	0	2.85442e-18	0.010818	3.21475e-18	25	183										T	47784399	G	T	47784399	3	4	20	1	0	0	0	0	1	0	0	0	14575	1328	46	4	864	4	SLC35B1	17	47784399	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1893331	47784399	33410811	345	6049										
ABCC3	8714	broad.mit.edu	37	chr17	48752728	48752728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cccaccctactgcagcgttgGaaggtgcagaggataaggag	14	10	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:48752728G>A	uc002isl.2	+	20	2685	c.2605G>A	c.(2605-2607)GAA>AAA	p.E869K		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	869	Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TGCAGCGTTGGAAGGTGCAGA	0.522													0	0	0	0.000602	0	5	84										A	48752728	G	A	48752728	3	1	20	1	0	0	0	0	1	0	0	0	54	1175	41	1	2767	1	ABCC3	17	48752728	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	968329	48752728	32442482	346	6050										
EFCAB3	146779	broad.mit.edu	37	chr17	60470976	60470976	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	agactttatcaaggttctaaCagataagaatctcttcctca	5	9	4	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:60470976C>G	uc002izu.1	+	5	416	c.338C>G	c.(337-339)ACA>AGA	p.T113R	EFCAB3_uc010wpc.1_Missense_Mutation_p.T165R	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	113	EF-hand 2.						calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			AAGGTTCTAACAGATAAGAAT	0.408													0	0	0	0.004656	0	20	83										G	60470976	C	G	60470976	3	3	20	1	0	0	0	0	1	0	0	0	4935	478	17	4	520	4	EFCAB3	17	60470976	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	11718248	60470976	20724234	347	6051										
DCAF7	10238	broad.mit.edu	37	chr17	61662585	61662585	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ttccgcaggtggtgattctaGatgtccgggttccctgcaca	12	11	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:61662585G>C	uc002jbc.2	+	7	968	c.751G>C	c.(751-753)GAT>CAT	p.D251H	DCAF7_uc002jbb.2_RNA|DCAF7_uc010wpn.1_Missense_Mutation_p.D51H	NM_005828	NP_005819	P61962	DCAF7_HUMAN	WD-repeat protein	251					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			ovary(1)	1						GGTGATTCTAGATGTCCGGGT	0.443													0	0	0	0.006214	0	7	139										C	61662585	G	C	61662585	3	2	20	1	0	0	0	0	1	0	0	0	4275	942	33	1	774	1	DCAF7	17	61662585	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1191609	61662585	19532625	348	6052										
CD79B	974	broad.mit.edu	37	chr17	62007656	62007656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccagctcacattgccggaggCgctgttcatgtagcagtgca	12	12	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:62007656C>T	uc002jdq.1	-	3	291	c.208G>A	c.(208-210)GCC>ACC	p.A70T	CD79B_uc002jdo.1_Missense_Mutation_p.A44T|CD79B_uc002jdp.1_Missense_Mutation_p.A71T|CD79B_uc002jdr.1_Intron	NM_000626	NP_000617	P40259	CD79B_HUMAN	CD79B antigen isoform 1 precursor	70	Extracellular (Potential).|Ig-like V-type.				cell surface receptor linked signaling pathway|immune response	Golgi apparatus|integral to plasma membrane|nucleus	transmembrane receptor activity				0						TTGCCGGAGGCGCTGTTCATG	0.572			Mis|O		DLBCL								0	0	0	0.000602	0	5	58										T	62007656	C	T	62007656	3	4	20	1	0	0	0	0	1	0	0	0	3037	768	27	2	497	2	CD79B	17	62007656	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	345071	62007656	19187554	349	6053										
PRKCA	5578	broad.mit.edu	37	chr17	64637500	64637500	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggagcaagcacaagttcaaaAtccacacttacggaagcccc	8	13	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:64637500A>T	uc002jfp.1	+	4	360	c.316A>T	c.(316-318)ATC>TTC	p.I106F	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	106	Phorbol-ester/DAG-type 2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	CAAGTTCAAAATCCACACTTA	0.458													0	0	0	0.01441	0	49	216										T	64637500	A	T	64637500	3	4	20	1	0	0	0	0	1	0	0	0	12507	101	4	5	330	5	PRKCA	17	64637500	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2629844	64637500	16557710	350	6054										
FDXR	2232	broad.mit.edu	37	chr17	72860379	72860379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggccccaggcacgggaggccGatgcctggcgggcagcttcc	17	15	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:72860379G>A	uc002jly.2	-	9	980	c.893C>T	c.(892-894)TCG>TTG	p.S298L	FDXR_uc010wri.1_Missense_Mutation_p.S246L|FDXR_uc010wrj.1_Missense_Mutation_p.S296L|FDXR_uc002jlw.2_Missense_Mutation_p.S55L|FDXR_uc002jlx.2_Missense_Mutation_p.S304L|FDXR_uc002jmc.2_Missense_Mutation_p.S270L|FDXR_uc010wrk.1_Missense_Mutation_p.S329L|FDXR_uc010wrl.1_Missense_Mutation_p.S341L|FDXR_uc002jma.2_Missense_Mutation_p.S299L|FDXR_uc010wrm.1_Missense_Mutation_p.S258L|FDXR_uc002jlz.2_Missense_Mutation_p.S290L|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	298					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					ACGGGAGGCCGATGCCTGGCG	0.692													0	0	0	0.008291	0	10	46										A	72860379	G	A	72860379	3	1	20	1	0	0	0	0	1	0	0	0	5807	1059	37	1	598	1	FDXR	17	72860379	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	8222879	72860379	8334831	351	6055										
GGA3	23163	broad.mit.edu	37	chr17	73239236	73239236	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cacaggaattggtgggtcagActgcactatgcctgaaaggg	14	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:73239236A>T	uc002jni.1	-	6	445	c.436T>A	c.(436-438)TCT>ACT	p.S146T	GGA3_uc002jnj.1_Missense_Mutation_p.S113T|GGA3_uc010wrw.1_Missense_Mutation_p.S24T|GGA3_uc002jnk.1_Missense_Mutation_p.S74T|GGA3_uc010wrx.1_Missense_Mutation_p.S24T|GGA3_uc010wry.1_Missense_Mutation_p.S74T|GGA3_uc010wrz.1_Intron	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	146	VHS.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			GGTGGGTCAGACTGCACTATG	0.542													0	0	0	0.012319	0	19	151										T	73239236	A	T	73239236	3	4	20	1	0	0	0	0	1	0	0	0	6354	275	10	5	1871	5	GGA3	17	73239236	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	378857	73239236	7955974	352	6056										
SRP68	6730	broad.mit.edu	37	chr17	74066468	74066468	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtgatactaacctgtacctcTgaaaatctccatgccgtaaa	6	11	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr17:74066468T>C	uc002jqk.1	-	2	277	c.242A>G	c.(241-243)CAG>CGG	p.Q81R	SRP68_uc010wsu.1_Intron|SRP68_uc002jql.1_Missense_Mutation_p.Q81R	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	81					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						CCTGTACCTCTGAAAATCTCC	0.373													0	0	0	0.003163	0	11	67										C	74066468	T	C	74066468	3	2	20	1	0	0	0	0	1	0	0	0	15155	1580	55	5	1701	5	SRP68	17	74066468	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	827232	74066468	7128742	353	6057										
MYOM1	8736	broad.mit.edu	37	chr18	3187533	3187533	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcaatgcaattttacattctCcttctcccaaaccgtgtggg	7	12	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:3187533C>A	uc002klp.2	-	5	1208	c.874G>T	c.(874-876)GAG>TAG	p.E292*	MYOM1_uc002klq.2_Nonsense_Mutation_p.E292*	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	292	Ig-like C2-type 1.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTTACATTCTCCTTCTCCCAA	0.433													1	0	3.86212e-05	0.008291	3.99378e-05	8	164										A	3187533	C	A	3187533	4	1	20	1	0	0	0	0	0	1	0	0	10091	864	30	3	4319	3	MYOM1	18	3187533	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		3187533	74889715	354	6058										
LAMA1	284217	broad.mit.edu	37	chr18	7044769	7044769	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcccggcctccagggctgctGatggtacccaggacagcacc	12	16	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:7044769G>A	uc002knm.2	-	7	1022	c.928C>T	c.(928-930)CAG>TAG	p.Q310*	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	310	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGGCTGCTGATGGTACCCA	0.478													0	0	0	0.010818	0	28	176										A	7044769	G	A	7044769	4	1	20	1	0	0	0	0	0	1	0	0	8605	1299	45	1	8527	1	LAMA1	18	7044769	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	3857236	7044769	71032479	355	6059										
TUBB6	84617	broad.mit.edu	37	chr18	12326037	12326037	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggcggagagcaacatgaacGacctggtatccgagtaccag	13	10	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:12326037G>A	uc002kqw.2	+	4	1294	c.1249G>A	c.(1249-1251)GAC>AAC	p.D417N	TUBB6_uc002kqv.2_Missense_Mutation_p.D345N|TUBB6_uc002kqx.2_Missense_Mutation_p.D380N|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	417					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		CAACATGAACGACCTGGTATC	0.557													0	0	0	0.006214	0	9	201										A	12326037	G	A	12326037	3	1	20	1	0	0	0	0	1	0	0	0	16757	1058	37	1	1263	1	TUBB6	18	12326037	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	5281268	12326037	65751211	356	6060										
MIB1	57534	broad.mit.edu	37	chr18	19321721	19321721	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gacaacggcacagctgccaaCtaccgctgctccggggctta	11	15	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:19321721C>T	uc002ktq.2	+	1	177	c.177C>T	c.(175-177)AAC>AAT	p.N59N	MIB1_uc002ktp.2_Intron	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	59	MIB/HERC2 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			CAGCTGCCAACTACCGCTGCT	0.721													0	0	0	0.001168	0	6	35										T	19321721	C	T	19321721	2	4	20	1	0	0	0	0	0	0	0	1	9566	564	20	2		2	MIB1	18	19321721	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	6995684	19321721	58755527	357	6061										
DSC3	1825	broad.mit.edu	37	chr18	28581659	28581659	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaatcttcaggaaaacgtttCcctttagttgcaccaaaaac	5	10	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:28581659C>G	uc002kwj.3	-	14	2315	c.2160G>C	c.(2158-2160)GGG>GGC	p.G720G	DSC3_uc002kwi.3_Silent_p.G720G	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	720	Cytoplasmic (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GAAAACGTTTCCCTTTAGTTG	0.284													0	0	0	0.00278	0	17	115										G	28581659	C	G	28581659	2	3	20	1	0	0	0	0	0	0	0	1	4767	842	30	1		1	DSC3	18	28581659	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	9259938	28581659	49495589	358	6062										
DSG3	1830	broad.mit.edu	37	chr18	29049227	29049227	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttacccaaccacaagcccTgggaccaggtatggcaggcc	10	15	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:29049227T>G	uc002kws.2	+	12	1921	c.1812T>G	c.(1810-1812)CCT>CCG	p.P604P		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	604	Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCACAAGCCCTGGGACCAGGT	0.592													0	0	0	0.006214	0	7	91										G	29049227	T	G	29049227	2	3	20	1	0	0	0	0	0	0	0	1	4778	1567	55	5		5	DSG3	18	29049227	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	467568	29049227	49028021	359	6063										
ATP8B1	5205	broad.mit.edu	37	chr18	55319836	55319836	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gctccaagaggtatgaagaaGaggatcatcgatgttaggac	13	6	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:55319836G>C	uc002lgw.2	-	24	3141	c.3141C>G	c.(3139-3141)CTC>CTG	p.L1047L	uc002lgu.1_Intron|uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	1047	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GTATGAAGAAGAGGATCATCG	0.463									Byler_disease				0	0	0	0.001984	0	5	89										C	55319836	G	C	55319836	2	2	20	1	0	0	0	0	0	0	0	1	1194	929	33	1		1	ATP8B1	18	55319836	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	26270609	55319836	22757412	360	6064										
VPS4B	9525	broad.mit.edu	37	chr18	61067362	61067362	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttgaaccacagagagaatCaatttcatcaatgaagataa	6	7	4	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:61067362C>G	uc002lix.2	-	7	969	c.709G>C	c.(709-711)GAT>CAT	p.D237H	VPS4B_uc010dpx.2_Missense_Mutation_p.D237H|VPS4B_uc010dpy.2_Missense_Mutation_p.D119H|VPS4B_uc010dpz.1_Missense_Mutation_p.D119H	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	237					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						CAGAGAGAATCAATTTCATCA	0.343													0	0	0	0.006122	0	16	118										G	61067362	C	G	61067362	3	3	20	1	0	0	0	0	1	0	0	0	17210	826	29	1	645	1	VPS4B	18	61067362	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5747526	61067362	17009886	361	6065										
PQLC1	80148	broad.mit.edu	37	chr18	77664069	77664069	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcctgccccaggatggccagGtccaccagcacctgcagcag	12	17	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr18:77664069G>A	uc002lnl.2	-	6	895	c.723C>T	c.(721-723)GAC>GAT	p.D241D	PQLC1_uc010dre.2_Silent_p.D158D|PQLC1_uc002lnk.2_Silent_p.D223D|PQLC1_uc010xfm.1_3'UTR	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	241	Helical; (Potential).					integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		GGATGGCCAGGTCCACCAGCA	0.682													0	0	0	0.001984	0	6	34										A	77664069	G	A	77664069	2	1	20	1	0	0	0	0	0	0	0	1	12418	1252	44	2		2	PQLC1	18	77664069	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	16596707	77664069	413179	362	6066										
PPAP2C	8612	broad.mit.edu	37	chr19	281413	281413	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggaggagtgcgggtatccaTagtggttgtggtcagcctcg	17	7	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:281413T>C	uc002loi.2	-	6	941	c.842A>G	c.(841-843)TAT>TGT	p.Y281C	PPAP2C_uc002loh.2_Missense_Mutation_p.Y302C|PPAP2C_uc002loj.2_Missense_Mutation_p.Y225C	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	281					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGTATCCATAGTGGTTGTG	0.657													0	0	0	0.001168	0	5	32										C	281413	T	C	281413	3	2	20	1	0	0	0	0	1	0	0	0	12292	1406	49	5	28	5	PPAP2C	19	281413	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08		281413	58847570	363	6067										
CNN2	1265	broad.mit.edu	37	chr19	1032581	1032581	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaaaacctgtccaacttcatCaaggccatggtcagctacgg	9	12	3	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:1032581C>G	uc002lqu.2	+	4	639	c.276C>G	c.(274-276)ATC>ATG	p.I92M	CNN2_uc002lqt.1_Missense_Mutation_p.I92M|CNN2_uc010drz.1_Intron|CNN2_uc002lqv.2_Missense_Mutation_p.I92M|CNN2_uc010xgb.1_Missense_Mutation_p.I92M|CNN2_uc010xgc.1_Missense_Mutation_p.I92M	NM_004368	NP_004359	Q99439	CNN2_HUMAN	calponin 2 isoform a	92	CH.				actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAACTTCATCAAGGCCATGG	0.507													0	0	0	0.001855	0	9	102										G	1032581	C	G	1032581	3	3	20	1	0	0	0	0	1	0	0	0	3610	816	29	1	290	1	CNN2	19	1032581	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	751168	1032581	58096402	364	6068										
ABCA7	10347	broad.mit.edu	37	chr19	1058041	1058041	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcatggccacctttgtgcttGagctcttctctgatcaggtg	11	11	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:1058041G>C	uc002lqw.3	+	36	5239	c.5008G>C	c.(5008-5010)GAG>CAG	p.E1670Q	ABCA7_uc002lqy.2_Missense_Mutation_p.E123Q|ABCA7_uc010dsc.2_5'Flank	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1670					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTTGTGCTTGAGCTCTTCTC	0.572													0	0	0	0.006214	0	8	93										C	1058041	G	C	1058041	3	2	20	1	0	0	0	0	1	0	0	0	37	1291	45	1	5146	1	ABCA7	19	1058041	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	25460	1058041	58070942	365	6069										
FAM108A1	81926	broad.mit.edu	37	chr19	1881473	1881473	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	accagggagtaggtggcctcCggcggcaggaaggcgagctt	18	10	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:1881473C>T	uc002lug.2	-	2	499	c.93G>A	c.(91-93)CCG>CCA	p.P31P	FAM108A1_uc002lud.2_Silent_p.P31P|FAM108A1_uc002lue.2_Silent_p.P31P|FAM108A1_uc002luf.2_Silent_p.P31P	NM_001130111	NP_001123583	Q96GS6	F18A1_HUMAN	hypothetical protein LOC81926 isoform 2	31						extracellular region	hydrolase activity				0		Ovarian(11;0.000137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGGCCTCCGGCGGCAGGA	0.711													0	0	0	0.000602	0	4	66										T	1881473	C	T	1881473	2	4	20	1	0	0	0	0	0	0	0	1	5391	639	23	2		2	FAM108A1	19	1881473	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	823432	1881473	57247510	366	6070										
THOP1	7064	broad.mit.edu	37	chr19	2810332	2810332	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccatgttcagcgggacccacGtggagcgggactttgtggag	16	10	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:2810332G>A	uc002lwj.2	+	10	1641	c.1486G>A	c.(1486-1488)GTG>ATG	p.V496M	THOP1_uc010xgz.1_Missense_Mutation_p.V375M|THOP1_uc002lwk.2_Missense_Mutation_p.V7M	NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	496					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGACCCACGTGGAGCGGGA	0.692													0	0	0	0.000602	0	4	55										A	2810332	G	A	2810332	3	1	20	1	0	0	0	0	1	0	0	0	15868	1145	40	2	1524	2	THOP1	19	2810332	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	928859	2810332	56318651	367	6071										
CLEC4G	339390	broad.mit.edu	37	chr19	7794268	7794268	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggggtcagcagttgtgccttTtctcacagatccagccgtcc	11	13	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:7794268T>A	uc002mhp.3	-	9	935	c.866A>T	c.(865-867)AAA>ATA	p.K289I		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	289	Extracellular (Potential).					integral to membrane	protein binding|sugar binding				0						GTTGTGCCTTTTCTCACAGAT	0.622													0	0	0	0.006214	0	7	46										A	7794268	T	A	7794268	3	1	20	1	0	0	0	0	1	0	0	0	3517	1841	64	5	19	5	CLEC4G	19	7794268	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	4983936	7794268	51334715	368	6072										
DOCK6	57572	broad.mit.edu	37	chr19	11313325	11313325	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttgtacacaaactcctgctCatccaggtcaccgaagtggg	9	13	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:11313325C>T	uc002mqs.3	-	42	5337	c.5296G>A	c.(5296-5298)GAG>AAG	p.E1766K	DOCK6_uc002mqr.3_Missense_Mutation_p.E166K|DOCK6_uc010xlq.1_Missense_Mutation_p.E1105K	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1766	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						AACTCCTGCTCATCCAGGTCA	0.622													0	0	0	0.013537	0	12	220										T	11313325	C	T	11313325	3	4	20	1	0	0	0	0	1	0	0	0	4691	835	29	1	875	1	DOCK6	19	11313325	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	3519057	11313325	47815658	369	6073										
JAK3	3718	broad.mit.edu	37	chr19	17942037	17942037	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cctaggcgcgggttccccacCagaaaatggggctctggcct	13	14	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:17942037C>G	uc002nhn.3	-	21	3078	c.2978G>C	c.(2977-2979)TGG>TCG	p.W993S	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.W993S	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	993	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						GGTTCCCCACCAGAAAATGGG	0.368		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.00245	0	10	74										G	17942037	C	G	17942037	3	3	20	1	0	0	0	0	1	0	0	0	7939	608	21	4	412	4	JAK3	19	17942037	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	6628712	17942037	41186946	370	6074										
COMP	1311	broad.mit.edu	37	chr19	18898425	18898425	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acttgtcctcgtccgtgttgCgctggtctgggttccgcacc	12	14	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:18898425C>T	uc002nke.2	-	10	1046	c.1010G>A	c.(1009-1011)CGC>CAC	p.R337H	COMP_uc002nkd.2_Missense_Mutation_p.R304H|COMP_uc010xqj.1_Missense_Mutation_p.R284H	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	337	TSP type-3 3.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						GTCCGTGTTGCGCTGGTCTGG	0.612													0	0	0	0.012319	0	21	160										T	18898425	C	T	18898425	3	4	20	1	0	0	0	0	1	0	0	0	3724	768	27	2	1303	2	COMP	19	18898425	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	956388	18898425	40230558	371	6075										
ZNF430	80264	broad.mit.edu	37	chr19	21239443	21239443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttatttctttcagttacatAttctcattttgcccaagacc	3	10	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:21239443A>G	uc002npj.2	+	5	439	c.329A>G	c.(328-330)TAT>TGT	p.Y110C	ZNF430_uc002npk.2_Missense_Mutation_p.Y109C	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						TCAGTTACATATTCTCATTTT	0.308													0	0	0	0.004482	0	7	63										G	21239443	A	G	21239443	3	3	20	1	0	0	0	0	1	0	0	0	17901	449	16	5	347	5	ZNF430	19	21239443	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	2341018	21239443	37889540	372	6076										
ZNF492	57615	broad.mit.edu	37	chr19	22836772	22836772	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cctgtctggagcaaggaaaaGaaccttggaatgtgaagaga	13	6	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:22836772G>C	uc002nqw.3	+	3	329	c.85G>C	c.(85-87)GAA>CAA	p.E29Q		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GCAAGGAAAAGAACCTTGGAA	0.423													0	0	0	0.008291	0	7	160										C	22836772	G	C	22836772	3	2	20	1	0	0	0	0	1	0	0	0	17940	943	33	1	91	1	ZNF492	19	22836772	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1597329	22836772	36292211	373	6077										
MLL4	9757	broad.mit.edu	37	chr19	36214059	36214059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ccatcacggcaagaagatgcGcatggctcgatgtggacact	12	11	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:36214059G>A	uc010eei.2	+	6	2885	c.2885G>A	c.(2884-2886)CGC>CAC	p.R962H		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	962	CXXC-type.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGAAGATGCGCATGGCTCGA	0.637													0	0	0	0.008291	0	7	69										A	36214059	G	A	36214059	3	1	20	1	0	0	0	0	1	0	0	0	9623	1087	38	2	2907	2	MLL4	19	36214059	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	13377287	36214059	22914924	374	6078										
ZNF383	163087	broad.mit.edu	37	chr19	37733704	37733704	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcacaatttattcaacatcAgagaattcatattggtgaaa	5	7	4	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:37733704A>C	uc002oft.1	+	8	1146	c.566A>C	c.(565-567)CAG>CCG	p.Q189P	ZNF383_uc002ofs.1_Missense_Mutation_p.Q124P|ZNF383_uc002ofu.1_Missense_Mutation_p.Q189P	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	189	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.Q189*(1)		ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCAACATCAGAGAATTCAT	0.338													0	0	0	0.009096	0	4	49										C	37733704	A	C	37733704	3	2	20	1	0	0	0	0	1	0	0	0	17871	188	7	5	580	5	ZNF383	19	37733704	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	1519645	37733704	21395279	375	6079										
CATSPERG	57828	broad.mit.edu	37	chr19	38861352	38861352	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgtctctgagacattccaggAtgggctccatgttcagctcc	10	13	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:38861352A>T	uc002oih.3	+	29	3487	c.3400A>T	c.(3400-3402)ATG>TTG	p.M1134L	CATSPERG_uc002oig.3_Missense_Mutation_p.M1094L|CATSPERG_uc002oif.3_Missense_Mutation_p.M774L|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1134	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						ACATTCCAGGATGGGCTCCAT	0.552													0	0	0	0.006122	0	15	124										T	38861352	A	T	38861352	3	4	20	1	0	0	0	0	1	0	0	0	2692	333	12	5	3510	5	CATSPERG	19	38861352	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	1127648	38861352	20267631	376	6080										
FAM98C	147965	broad.mit.edu	37	chr19	38896259	38896259	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cactacatctgctttccactGgagtgaccgggcagaggtgt	12	11	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:38896259G>A	uc002oin.1	+	6	753	c.734G>A	c.(733-735)TGG>TAG	p.W245*	FAM98C_uc002oio.1_Nonsense_Mutation_p.W219*|FAM98C_uc010xtz.1_Intron	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	245										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCTTTCCACTGGAGTGACCGG	0.612													0	0	0	0.001984	0	6	71										A	38896259	G	A	38896259	4	1	20	1	0	0	0	0	0	1	0	0	5658	1357	47	2	756	2	FAM98C	19	38896259	Nonsense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	34907	38896259	20232724	377	6081										
PLD3	23646	broad.mit.edu	37	chr19	40872687	40872687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctcctccccacagaaagcccGctgggtcctgctggtcctca	9	18	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:40872687G>A	uc002onm.3	+	5	508	c.110G>A	c.(109-111)CGC>CAC	p.R37H	PLD3_uc002onj.3_Missense_Mutation_p.R37H|PLD3_uc002onk.3_Missense_Mutation_p.R37H|PLD3_uc002onl.3_Missense_Mutation_p.R37H|PLD3_uc002onn.2_Missense_Mutation_p.R37H|PLD3_uc002ono.2_Silent_p.P66P	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	37	Cytoplasmic (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			CAGAAAGCCCGCTGGGTCCTG	0.627													0	0	0	0.001168	0	5	54										A	40872687	G	A	40872687	3	1	20	1	0	0	0	0	1	0	0	0	12047	1087	38	2	120	2	PLD3	19	40872687	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1976428	40872687	18256296	378	6082										
ERCC2	2068	broad.mit.edu	37	chr19	45867571	45867571	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggtgaggttgacgctcatgGagtcgatgcagacgttgtct	16	7	2	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:45867571G>T	uc002pbj.2	-	9	784	c.737C>A	c.(736-738)TCC>TAC	p.S246Y	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.S168Y|ERCC2_uc002pbk.2_Missense_Mutation_p.S222Y|ERCC2_uc002pbl.3_Missense_Mutation_p.S222Y|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	246	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GACGCTCATGGAGTCGATGCA	0.682			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				1	0	3.09899e-07	0.004482	3.27916e-07	8	76										T	45867571	G	T	45867571	3	4	20	1	0	0	0	0	1	0	0	0	5213	1174	41	3	1662	3	ERCC2	19	45867571	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4994884	45867571	13261412	379	6083										
CCDC8	83987	broad.mit.edu	37	chr19	46915949	46915949	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cttccaggaactgggtcagcCgctcccgaaattctgcttcc	9	15	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:46915949C>A	uc002pep.2	-	1	971	c.119G>T	c.(118-120)CGG>CTG	p.R40L		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	40						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		ctgggtcagccgctcccgaaa	0.104													1	0	5.50884e-06	0.013537	5.78873e-06	10	107										A	46915949	C	A	46915949	3	1	20	1	0	0	0	0	1	0	0	0	2853	652	23	4	1501	4	CCDC8	19	46915949	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1048378	46915949	12213034	380	6084										
PNMAL2	57469	broad.mit.edu	37	chr19	46998670	46998670	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cggtgaccagcagggccctgTgcgcgtccacgtccaggctc	14	16	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:46998670T>C	uc002pes.2	-	1	500	c.53A>G	c.(52-54)CAC>CGC	p.H18R	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	18										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		cagggccctgtgcgcgtccac	0.154													0	0	0	0.008291	0	7	59										C	46998670	T	C	46998670	3	2	20	1	0	0	0	0	1	0	0	0	12158	1696	59	5	1858	5	PNMAL2	19	46998670	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	82721	46998670	12130313	381	6085										
KPTN	11133	broad.mit.edu	37	chr19	47984066	47984066	+	Frame_Shift_Del	DEL	C	C	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaggttttccacgggctgttCctcaaactgatgcagcccct							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:47984066delC	uc002pgy.2	-	6	654	c.550delG	c.(550-552)GAAfs	p.E184fs	KPTN_uc010xys.1_RNA	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	184					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)		ACGGGCTGTTCCTCAAACTGA	0.602																		27	327	---	---								-	47984066	C	-	47984066	7	5	20	1	0	1	0	1	0	0	0	0	8437	864	30	0	788	0	KPTN	19	47984066	Frame_Shift_Del	DEL	C	TCGA-BT-A3PK-01A-21D-A21Z-08	985396	47984066	11144917	382	6086										
HRC	3270	broad.mit.edu	37	chr19	49657934	49657934	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttctccttcatcatcttcCccatcatggcctcggtgtcc	5	17	6	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr19:49657934C>G	uc002pmv.2	-	1	748	c.561G>C	c.(559-561)GGG>GGC	p.G187G		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	187	4 X tandem repeats, acidic.|1-1.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CATCATCTTCCCCATCATGGC	0.463													0	0	0	0.004482	0	8	97										G	49657934	C	G	49657934	2	3	20	1	0	0	0	0	0	0	0	1	7352	610	22	4		4	HRC	19	49657934	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1673868	49657934	9471049	383	6087										
ZNF343	79175	broad.mit.edu	37	chr20	2463828	2463828	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cagtgtgtcctctggtgtctGatgagatttgacttatgact	11	7	2	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:2463828G>A	uc002wge.1	-	6	2267	c.1779C>T	c.(1777-1779)ATC>ATT	p.I593I	ZNF343_uc010gao.1_Silent_p.I593I|ZNF343_uc002wgd.1_Silent_p.I503I	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	593	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCTGGTGTCTGATGAGATTTG	0.507													0	0	0	0.010729	0	9	75										A	2463828	G	A	2463828	2	1	20	1	0	0	0	0	0	0	0	1	17855	1280	45	1		1	ZNF343	20	2463828	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08		2463828	60561692	384	6088										
BPIL3	128859	broad.mit.edu	37	chr20	31624294	31624294	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggcaccgtcaaatatgttctGatgtccgcaccagccaccac	8	15	2	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:31624294G>C	uc010zuc.1	+	7	621	c.621G>C	c.(619-621)CTG>CTC	p.L207L	BPIL3_uc010zud.1_Silent_p.L146L	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	207						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						AATATGTTCTGATGTCCGCAC	0.587													0	0	0	0.009535	0	24	319										C	31624294	G	C	31624294	2	2	20	1	0	0	0	0	0	0	0	1	1493	1277	45	1		1	BPIL3	20	31624294	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	29160466	31624294	31401226	385	6089										
TRPC4AP	26133	broad.mit.edu	37	chr20	33593524	33593524	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tatccacctggttttcaaatCggtccagggacagagtgaca	10	10	1	2	rs143166417	byFrequency	TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:33593524C>T	uc002xbk.2	-	16	1944	c.1910G>A	c.(1909-1911)CGA>CAA	p.R637Q	TRPC4AP_uc002xbj.2_RNA|TRPC4AP_uc010zuq.1_Missense_Mutation_p.R228Q|TRPC4AP_uc002xbl.2_Missense_Mutation_p.R629Q|TRPC4AP_uc010zur.1_Missense_Mutation_p.R598Q	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	637					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GTTTTCAAATCGGTCCAGGGA	0.507													0	0	0	0.006122	0	13	108										T	33593524	C	T	33593524	3	4	20	1	0	0	0	0	1	0	0	0	16578	884	31	1	499	1	TRPC4AP	20	33593524	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1969230	33593524	29431996	386	6090										
PHF20	51230	broad.mit.edu	37	chr20	34457364	34457364	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttataaacatggtagctgtGgattcaaactctcaaacttt	6	7	2	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:34457364G>T	uc002xek.1	+	7	924	c.813G>T	c.(811-813)GTG>GTT	p.V271V	PHF20_uc002xei.1_Silent_p.V271V|PHF20_uc010gfo.1_Silent_p.V271V|PHF20_uc002xej.1_Silent_p.V155V|PHF20_uc002xel.1_Silent_p.V133V	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					TGGTAGCTGTGGATTCAAACT	0.294													1	0	3.27435e-08	0.00245	3.49725e-08	14	68										T	34457364	G	T	34457364	2	4	20	1	0	0	0	0	0	0	0	1	11831	1335	47	4		4	PHF20	20	34457364	Silent	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	863840	34457364	28568156	387	6091										
CHD6	84181	broad.mit.edu	37	chr20	40033522	40033522	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	acatggatgggtaaatgagtCcaggagatactcctgggatg	14	6	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:40033522C>A	uc002xka.1	-	37	8037	c.7859G>T	c.(7858-7860)GGA>GTA	p.G2620V	CHD6_uc002xjz.1_Missense_Mutation_p.G157V	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2620					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GTAAATGAGTCCAGGAGATAC	0.512													1	0	0.00010058	0.013537	0.000103538	13	56										A	40033522	C	A	40033522	3	1	20	1	0	0	0	0	1	0	0	0	3329	855	30	3	292	3	CHD6	20	40033522	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5576158	40033522	22991998	388	6092										
CHD6	84181	broad.mit.edu	37	chr20	40118569	40118569	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggcgataatgagaaaagggCcgtggattcctctcagaaat	13	7	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:40118569C>A	uc002xka.1	-	12	1707	c.1529G>T	c.(1528-1530)GGC>GTC	p.G510V	CHD6_uc002xkd.2_Missense_Mutation_p.G488V	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	510	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GAGAAAAGGGCCGTGGATTCC	0.493													1	0	4.59853e-10	0.005443	5.00558e-10	27	119										A	40118569	C	A	40118569	3	1	20	1	0	0	0	0	1	0	0	0	3329	739	26	4	6722	4	CHD6	20	40118569	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	85047	40118569	22906951	389	6093										
PCK1	5105	broad.mit.edu	37	chr20	56136669	56136669	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aggaagagggcatcctcaggCggctgaagaagtatgacaac	14	8	1	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:56136669C>T	uc002xyn.3	+	2	365	c.202C>T	c.(202-204)CGG>TGG	p.R68W	PCK1_uc010zzm.1_5'UTR	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	68					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CATCCTCAGGCGGCTGAAGAA	0.617													0	0	0	0.001855	0	12	110										T	56136669	C	T	56136669	3	4	20	1	0	0	0	0	1	0	0	0	11581	759	27	2	204	2	PCK1	20	56136669	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	16018100	56136669	6888851	390	6094										
LAMA5	3911	broad.mit.edu	37	chr20	60904247	60904247	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atgaagtcataggatttatcCaggggctcctcccggaggta	12	9	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr20:60904247C>T	uc002ycq.2	-	33	4249	c.4182G>A	c.(4180-4182)CTG>CTA	p.L1394L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1394	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGATTTATCCAGGGGCTCCT	0.637													0	0	0	0.014323	0	21	120										T	60904247	C	T	60904247	2	4	20	1	0	0	0	0	0	0	0	1	8609	581	21	2		2	LAMA5	20	60904247	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	4767578	60904247	2121273	391	6095										
ADAMTS5	11096	broad.mit.edu	37	chr21	28296403	28296403	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcaacaagcattgcttaaacGcagaaggcctttgggagaga	11	8	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr21:28296403G>A	uc002ymg.2	-	8	3491	c.2762C>T	c.(2761-2763)GCG>GTG	p.A921V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	921	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TTGCTTAAACGCAGAAGGCCT	0.483													0	0	0	0.010729	0	10	68										A	28296403	G	A	28296403	3	1	20	1	0	0	0	0	1	0	0	0	269	1087	38	2	34	2	ADAMTS5	21	28296403	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08		28296403	19833492	392	6096										
RNF160	26046	broad.mit.edu	37	chr21	30331900	30331900	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gaaatagttataggccacatCacagataaaagacactgatg	8	7	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr21:30331900C>A	uc002ymr.2	-	13	2624	c.2611G>T	c.(2611-2613)GAT>TAT	p.D871Y		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	825							ligase activity|zinc ion binding				0						TAGGCCACATCACAGATAAAA	0.343													1	0	3.62473e-10	0.012319	3.95504e-10	18	102										A	30331900	C	A	30331900	3	1	20	1	0	0	0	0	1	0	0	0	13455	826	29	3	2899	3	RNF160	21	30331900	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2035497	30331900	17797995	393	6097										
KRTAP13-2	337959	broad.mit.edu	37	chr21	31744204	31744204	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gctcctcgatccatagcccaGggagcggcagctgctggatc	13	14	0	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr21:31744204G>T	uc002ynz.3	-	1	354	c.328C>A	c.(328-330)CTG>ATG	p.L110M		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	110						intermediate filament					0						CCATAGCCCAGGGAGCGGCAG	0.597													1	0	1.12685e-05	0.004482	1.17866e-05	7	60										T	31744204	G	T	31744204	3	4	20	1	0	0	0	0	1	0	0	0	8523	991	35	4	203	4	KRTAP13-2	21	31744204	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	1412304	31744204	16385691	394	6098										
BRWD1	54014	broad.mit.edu	37	chr21	40650683	40650683	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tcttaccaacactaaaagaaGaacaaagcatttgaacgcct	5	10	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr21:40650683G>A	uc002yxk.1	-	10	1128	c.989C>T	c.(988-990)TCT>TTT	p.S330F	BRWD1_uc002yxl.2_Missense_Mutation_p.S330F|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_5'UTR|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.S50F	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	330	WD 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ACTAAAAGAAGAACAAAGCAT	0.328													0	0	0	0.004482	0	6	110										A	40650683	G	A	40650683	3	1	20	1	0	0	0	0	1	0	0	0	1525	942	33	1	6344	1	BRWD1	21	40650683	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	8906479	40650683	7479212	395	6099										
DGCR8	54487	broad.mit.edu	37	chr22	20074169	20074169	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	taaagcaatcgttcagagagAcagagtggatgaagaggcct	13	6	1	5			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:20074169A>G	uc002zri.2	+	2	1033	c.683A>G	c.(682-684)GAC>GGC	p.D228G	DGCR8_uc010grz.2_Missense_Mutation_p.D228G|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	228	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					GTTCAGAGAGACAGAGTGGAT	0.478													0	0	0	0.009718	0	39	261										G	20074169	A	G	20074169	3	3	20	1	0	0	0	0	1	0	0	0	4464	275	10	5	685	5	DGCR8	22	20074169	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08		20074169	31230397	396	6100										
TOP3B	8940	broad.mit.edu	37	chr22	22314027	22314027	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gggtgtggcccaggacctggCggtagtcggccttgccctgg	18	12	0	0	rs138357708		TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:22314027C>T	uc002zvs.2	-	15	2171	c.1736G>A	c.(1735-1737)CGC>CAC	p.R579H	TOP3B_uc010gtm.1_Missense_Mutation_p.R124H|TOP3B_uc002zvr.2_Missense_Mutation_p.R304H|TOP3B_uc010gtl.2_Missense_Mutation_p.R579H|TOP3B_uc002zvt.3_Missense_Mutation_p.R579H	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	579					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CAGGACCTGGCGGTAGTCGGC	0.622													0	0	0	0.010504	0	20	211										T	22314027	C	T	22314027	3	4	20	1	0	0	0	0	1	0	0	0	16365	768	27	2	868	2	TOP3B	22	22314027	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2239858	22314027	28990539	397	6101										
GNAZ	2781	broad.mit.edu	37	chr22	23438386	23438386	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgcatcgccgcagctgactaTatccccactgtcgaggacat	9	15	0	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:23438386T>C	uc002zwu.1	+	2	1041	c.504T>C	c.(502-504)TAT>TAC	p.Y168Y	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	168						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		CAGCTGACTATATCCCCACTG	0.607													0	0	0	0.010729	0	11	90										C	23438386	T	C	23438386	2	2	20	1	0	0	0	0	0	0	0	1	6514	1413	49	5		5	GNAZ	22	23438386	Silent	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	1124359	23438386	27866180	398	6102										
RAB36	9609	broad.mit.edu	37	chr22	23500179	23500179	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggctttttccgggtgtctagTgatcatcacggcctttgacc	11	11	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:23500179T>A	uc002zwv.1	+	7	633	c.593T>A	c.(592-594)GTG>GAG	p.V198E	RAB36_uc010gtw.1_Missense_Mutation_p.V176E	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	198					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		GGGTGTCTAGTGATCATCACG	0.622													0	0	0	0.004289	0	28	249										A	23500179	T	A	23500179	3	1	20	1	0	0	0	0	1	0	0	0	12926	1710	59	5	619	5	RAB36	22	23500179	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	61793	23500179	27804387	399	6103										
EMID1	129080	broad.mit.edu	37	chr22	29622494	29622494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	cgcaggttgtctcaactgcaGcaaagtgtcagagctgacag	12	10	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:29622494G>A	uc003aen.2	+	5	488	c.413G>A	c.(412-414)AGC>AAC	p.S138N	EMID1_uc003aem.2_Missense_Mutation_p.S140N|EMID1_uc003aeo.2_Missense_Mutation_p.S140N|EMID1_uc003aep.2_Missense_Mutation_p.S140N	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	138						collagen					0						CTCAACTGCAGCAAAGTGTCA	0.632													0	0	0	0.006122	0	15	55										A	29622494	G	A	29622494	3	1	20	1	0	0	0	0	1	0	0	0	5091	971	34	2	437	2	EMID1	22	29622494	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	6122315	29622494	21682072	400	6104										
NCF4	4689	broad.mit.edu	37	chr22	37261076	37261080	+	Frame_Shift_Del	DEL	AGAGC	AGAGC	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcgcttcgggccagacagcaAgagcagtgccctggcctgta							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:37261076_37261080delAGAGC	uc003apy.3	+	3	417_421	c.233_237delAGAGC	c.(232-237)AAGAGCfs	p.K78fs	NCF4_uc003apz.3_Frame_Shift_Del_p.K78fs	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	78_79	PX.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						CCAGACAGCAAGAGCAGTGCCCTGG	0.62																		18	136	---	---								-	37261080	AGAGC	-	37261076	7	5	20	1	0	1	0	1	0	0	0	0	10218	72	3	0	243	0	NCF4	22	37261076	Frame_Shift_Del	DEL	AGAGC	TCGA-BT-A3PK-01A-21D-A21Z-08	7638582	37261076	14043490	401	6105										
EP300	2033	broad.mit.edu	37	chr22	41553402	41553402	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gcaaagccttggatactgttGtggcagaaaggtaagaaatg	13	5	0	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:41553402G>A	uc003azl.3	+	18	3886	c.3491G>A	c.(3490-3492)TGT>TAT	p.C1164Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1164					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGATACTGTTGTGGCAGAAAG	0.393			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.004878	0	30	121										A	41553402	G	A	41553402	3	1	20	1	0	0	0	0	1	0	0	0	5148	1377	48	2	3561	2	EP300	22	41553402	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	4292326	41553402	9751164	402	6106										
ACO2	50	broad.mit.edu	37	chr22	41918881	41918881	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gctatgaagatatggggcgcTcagcagctgtggccaagcag	15	9	1	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:41918881T>A	uc003bac.2	+	10	1208	c.1186T>A	c.(1186-1188)TCA>ACA	p.S396T	ACO2_uc003bad.2_Missense_Mutation_p.S421T	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	396					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						TATGGGGCGCTCAGCAGCTGT	0.572													0	0	0	0.008871	0	19	78										A	41918881	T	A	41918881	3	1	20	1	0	0	0	0	1	0	0	0	147	1551	54	5	1224	5	ACO2	22	41918881	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	365479	41918881	9385685	403	6107										
TTLL1	25809	broad.mit.edu	37	chr22	43459894	43459894	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctggtactcggggtgtatttCactgtgcagaaccggcaaaa	12	9	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:43459894C>T	uc003bdi.2	-	7	913	c.672G>A	c.(670-672)GTG>GTA	p.V224V	TTLL1_uc010gzh.2_Silent_p.V224V|TTLL1_uc003bdj.2_Silent_p.V110V|TTLL1_uc003bdh.2_Silent_p.V186V	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	224	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		GGGTGTATTTCACTGTGCAGA	0.458													0	0	0	0.004482	0	6	159										T	43459894	C	T	43459894	2	4	20	1	0	0	0	0	0	0	0	1	16719	813	29	1		1	TTLL1	22	43459894	Silent	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	1541013	43459894	7844672	404	6108										
SMC1B	27127	broad.mit.edu	37	chr22	45802460	45802460	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tttcttttcttcatattctcCtataagctctcctgaagtgc	4	11	5	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chr22:45802460C>T	uc003bgc.2	-	4	548	c.496G>A	c.(496-498)GGA>AGA	p.G166R	SMC1B_uc003bgd.2_Missense_Mutation_p.G166R|SMC1B_uc003bge.1_5'UTR	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	166	Potential.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCATATTCTCCTATAAGCTCT	0.363													0	0	0	0.000602	0	5	57										T	45802460	C	T	45802460	3	4	20	1	0	0	0	0	1	0	0	0	14782	690	24	2	3299	2	SMC1B	22	45802460	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	2342566	45802460	5502106	405	6109										
DYNLT3	6990	broad.mit.edu	37	chrX	37705596	37705596	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gacaatattgtgggcttcctCagcattgaagccaacctaaa	8	10	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:37705596C>T	uc004dds.2	-	2	172	c.46G>A	c.(46-48)GAG>AAG	p.E16K		NM_006520	NP_006511	P51808	DYLT3_HUMAN	dynein, light chain, Tctex-type 3	16					cell division|mitosis|regulation of mitotic cell cycle|transport	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|nucleus|plasma membrane	motor activity				0						TGGGCTTCCTCAGCATTGAAG	0.408													0	0	0	0.004482	0	6	21										T	37705596	C	T	37705596	3	4	20	1	0	0	0	0	1	0	0	0	4853	835	29	1	320	1	DYNLT3	23	37705596	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08		37705596	117564964	406	6110										
USP9X	8239	broad.mit.edu	37	chrX	41075732	41075732	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttgataagatatatatcagAgcttgctatcaccaccagac	7	9	2	4			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:41075732A>G	uc004dfb.2	+	35	6545	c.5912A>G	c.(5911-5913)GAG>GGG	p.E1971G	USP9X_uc004dfc.2_Missense_Mutation_p.E1971G	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1971					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TATATATCAGAGCTTGCTATC	0.398													0	0	0	0.00632	0	24	54										G	41075732	A	G	41075732	3	3	20	1	0	0	0	0	1	0	0	0	17087	304	11	5	6046	5	USP9X	23	41075732	Missense_Mutation	SNP	A	TCGA-BT-A3PK-01A-21D-A21Z-08	3370136	41075732	114194828	407	6111										
TFE3	7030	broad.mit.edu	37	chrX	48887952	48887952	+	Frame_Shift_Del	DEL	C	C	-													0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ggggagcattctgggcaggtCccccccctacatggaacgtt							TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:48887952delC	uc004dmb.3	-	10	1683	c.1445delG	c.(1444-1446)GGAfs	p.G482fs	TFE3_uc004dmc.3_Frame_Shift_Del_p.G377fs	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	482					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						CTGGGCAGGTCCCCCCCCTAC	0.647			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal													40	122	---	---								-	48887952	C	-	48887952	7	5	20	1	0	1	0	1	0	0	0	0	15797	855	30	0	286	0	TFE3	23	48887952	Frame_Shift_Del	DEL	C	TCGA-BT-A3PK-01A-21D-A21Z-08	7812220	48887952	106382608	408	6112										
RLIM	51132	broad.mit.edu	37	chrX	73812092	73812092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gttcactttcataggtgacaGtgttgtttggtgtctgagac	12	6	3	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:73812092G>A	uc004ebu.2	-	5	1348	c.1058C>T	c.(1057-1059)ACT>ATT	p.T353I	RLIM_uc004ebw.2_Missense_Mutation_p.T353I	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	353					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						ATAGGTGACAGTGTTGTTTGG	0.468													0	0	0	0.003163	0	14	44										A	73812092	G	A	73812092	3	1	20	1	0	0	0	0	1	0	0	0	13390	1029	36	2	820	2	RLIM	23	73812092	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	24924140	73812092	81458468	409	6113										
BTK	695	broad.mit.edu	37	chrX	100617587	100617587	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aaatttggcagcccatagcaTttttggctgtctgagagcag	11	8	1	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:100617587T>G	uc004ehg.2	-	6	675	c.482A>C	c.(481-483)AAT>ACT	p.N161T	BTK_uc010nnn.2_Missense_Mutation_p.N161T|BTK_uc010nno.2_Missense_Mutation_p.N195T|BTK_uc004ehi.2_Missense_Mutation_p.N161T	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	161	Btk-type.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						GCCCATAGCATTTTTGGCTGT	0.448									Agammaglobulinemia_X-linked				0	0	0	0.01441	0	46	84										G	100617587	T	G	100617587	3	3	20	1	0	0	0	0	1	0	0	0	1557	1493	52	5	1553	5	BTK	23	100617587	Missense_Mutation	SNP	T	TCGA-BT-A3PK-01A-21D-A21Z-08	26805495	100617587	54652973	410	6114										
NGFRAP1	27018	broad.mit.edu	37	chrX	102632754	102632754	+	Nonstop_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	tgaattttgccttatgccttGactcctgccatttatcatga	6	10	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:102632754G>T	uc004eki.2	+	3	717	c.335G>T	c.(334-336)TGA>TTA	p.*112L	NGFRAP1_uc004ekh.2_Nonstop_Mutation_p.*102L|NGFRAP1_uc004ekj.1_Nonstop_Mutation_p.*112L	NM_206915	NP_996798	Q00994	BEX3_HUMAN	nerve growth factor receptor (TNFRSF16)	112					apoptosis|multicellular organismal development|nerve growth factor receptor signaling pathway	cytosol|nucleus	caspase regulator activity|metal ion binding				0						CTTATGCCTTGACTCCTGCCA	0.418													1	0	3.09899e-07	0.004482	3.27916e-07	9	42										T	102632754	G	T	102632754	4	4	20	1	0	0	0	0	0	0	0	0	10397	1285	45	3	337	3	NGFRAP1	23	102632754	Nonstop_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	2015167	102632754	52637806	411	6115										
RGAG1	57529	broad.mit.edu	37	chrX	109697168	109697168	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	ctctggagaggcatccacctCtcacattaacatcacagcct	6	15	3	1			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:109697168C>G	uc004eor.1	+	3	3569	c.3323C>G	c.(3322-3324)TCT>TGT	p.S1108C	RGAG1_uc011msr.1_Missense_Mutation_p.S1108C	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1108										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GCATCCACCTCTCACATTAAC	0.532													0	0	0	0.003163	0	14	112										G	109697168	C	G	109697168	3	3	20	1	0	0	0	0	1	0	0	0	13274	913	32	1	3325	1	RGAG1	23	109697168	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	7064414	109697168	45573392	412	6116										
BCORL1	63035	broad.mit.edu	37	chrX	129150054	129150054	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	gtaggggtctttgcttgcaaGaacaagtggcagccagatga	14	7	1	3			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:129150054G>T	uc004evb.1	+	4	3420	c.3306G>T	c.(3304-3306)AAG>AAT	p.K1102N	BCORL1_uc010nrd.1_Missense_Mutation_p.K1004N	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1102					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TTGCTTGCAAGAACAAGTGGC	0.577													1	0	7.76418e-22	0.005443	8.85389e-22	21	58										T	129150054	G	T	129150054	3	4	20	1	0	0	0	0	1	0	0	0	1387	933	33	3	3316	3	BCORL1	23	129150054	Missense_Mutation	SNP	G	TCGA-BT-A3PK-01A-21D-A21Z-08	19452886	129150054	26120506	413	6117										
AFF2	2334	broad.mit.edu	37	chrX	147743712	147743712	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	aatacacagcaacagaaaatCaaaacctgagtggtcacgtg	8	9	2	2			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:147743712C>G	uc004fcp.2	+	3	943	c.464C>G	c.(463-465)TCA>TGA	p.S155*	AFF2_uc004fco.2_Nonsense_Mutation_p.S151*|AFF2_uc004fcq.2_Nonsense_Mutation_p.S151*|AFF2_uc004fcr.2_Nonsense_Mutation_p.S151*|AFF2_uc011mxb.1_Nonsense_Mutation_p.S155*|AFF2_uc004fcs.2_Nonsense_Mutation_p.S151*	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	155					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AACAGAAAATCAAAACCTGAG	0.463													0	0	0	0.00333	0	23	173										G	147743712	C	G	147743712	4	3	20	1	0	0	0	0	0	1	0	0	357	838	29	1	474	1	AFF2	23	147743712	Nonsense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	18593658	147743712	7526848	414	6118										
L1CAM	3897	broad.mit.edu	37	chrX	153128264	153128264	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.239130434782609	99	7.09188447887169e-22	2.76105399121674	3.41385063915676	2.35417388873358	0.580404648091503	0.7111952018206	63	atccacgctgcccccataatCggccaggctgtcgtcactgc	9	17	1	0			TCGA-BT-A3PK-01A-21D-A21Z-08	TCGA-BT-A3PK-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4ad38e8e-e63e-41d9-9216-617be7fa1d75	eb8ecd73-a631-4193-a59a-d841e08d51e9	g.chrX:153128264C>T	uc004fjb.2	-	28	3736	c.3628G>A	c.(3628-3630)GAT>AAT	p.D1210N	L1CAM_uc004fjc.2_Missense_Mutation_p.D1206N|L1CAM_uc010nuo.2_Missense_Mutation_p.D1201N	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1210	Cytoplasmic (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCCATAATCGGCCAGGCTG	0.597													0	0	0	0.014323	0	18	42										T	153128264	C	T	153128264	3	4	20	1	0	0	0	0	1	0	0	0	8588	884	31	1	149	1	L1CAM	23	153128264	Missense_Mutation	SNP	C	TCGA-BT-A3PK-01A-21D-A21Z-08	5384552	153128264	2142296	415	6119										
EPHA2	1969	broad.mit.edu	37	chr1	16477440	16477440	+	Frame_Shift_Del	DEL	G	G	-													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cgagctcccctccagctgcaGcaaagtccagcagtaccact							TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:16477440delG	uc001aya.1	-	2	241	c.104delC	c.(103-105)GCTfs	p.A35fs	EPHA2_uc010oca.1_Frame_Shift_Del_p.A35fs	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	35	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TCCAGCTGCAGCAAAGTCCAG	0.597																		57	39	---	---								-	16477440	G	-	16477440	7	5	21	1	0	1	0	1	0	0	0	0	5167	971	34	0	2890	0	EPHA2	1	16477440	Frame_Shift_Del	DEL	G	TCGA-BT-A42B-01A-32D-A23M-08		16477440	232773181	1	6120										
KIAA0467	23334	broad.mit.edu	37	chr1	43893772	43893772	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cctgctgcaggagcatgcacAgcggtgctatgtccgtggtg	15	11	0	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:43893772A>G	uc001cjk.1	+	12	1667	c.1205A>G	c.(1204-1206)CAG>CGG	p.Q402R		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1301						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GAGCATGCACAGCGGTGCTAT	0.637													0	0	0	0.019004	0	34	69										G	43893772	A	G	43893772	3	3	21	1	0	0	0	0	1	0	0	0	8178	188	7	5	1243	5	KIAA0467	1	43893772	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	27416332	43893772	205356849	2	6121										
KANK4	163782	broad.mit.edu	37	chr1	62740332	62740332	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccactcccaaaagtgagctcGgcatcctctggctcagcagc	9	16	2	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:62740332G>A	uc001dah.3	-	3	821	c.444C>T	c.(442-444)GCC>GCT	p.A148A	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	148										ovary(3)|skin(2)|lung(1)	6						AAGTGAGCTCGGCATCCTCTG	0.627													0	0	0	0.012319	0	21	47										A	62740332	G	A	62740332	2	1	21	1	0	0	0	0	0	0	0	1	7979	1103	39	2		2	KANK4	1	62740332	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	18846560	62740332	186510289	3	6122										
LEPR	3953	broad.mit.edu	37	chr1	66075760	66075760	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttggagtaattggagcaatcCagcctacacagttgtcatgg	11	8	1	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:66075760C>A	uc001dci.2	+	13	2085	c.1883C>A	c.(1882-1884)CCA>CAA	p.P628Q	LEPR_uc001dcg.2_Missense_Mutation_p.P628Q|LEPR_uc001dch.2_Missense_Mutation_p.P628Q|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.P628Q|LEPR_uc001dck.2_Missense_Mutation_p.P628Q	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	628	Extracellular (Potential).|Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGGAGCAATCCAGCCTACACA	0.423													1	0	4.88506e-25	0.01441	5.47362e-25	60	71										A	66075760	C	A	66075760	3	1	21	1	0	0	0	0	1	0	0	0	8728	594	21	4	1925	4	LEPR	1	66075760	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	3335428	66075760	183174861	4	6123										
IGSF9	57549	broad.mit.edu	37	chr1	159898436	159898436	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccaggacctggcaagggactGggtggggctgctggaggggg	22	8	0	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:159898436G>A	uc001fur.2	-	19	2940	c.2742C>T	c.(2740-2742)CCC>CCT	p.P914P	IGSF9_uc001fuq.2_Silent_p.P898P|IGSF9_uc001fup.2_Silent_p.P60P	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	914	Pro-rich.|Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCAAGGGACTGGGTGGGGCTG	0.652													0	0	0	0.014758	0	5	9										A	159898436	G	A	159898436	2	1	21	1	0	0	0	0	0	0	0	1	7605	1335	47	2		2	IGSF9	1	159898436	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	93822676	159898436	89352185	5	6124										
NCF2	4688	broad.mit.edu	37	chr1	183559371	183559371	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccgggagtgggggtcctggaCggcactgaaggcatccaggg	19	10	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:183559371C>T	uc001gqj.3	-	1	369	c.94G>A	c.(94-96)GTC>ATC	p.V32I	NCF2_uc010pod.1_Missense_Mutation_p.V32I|NCF2_uc010poe.1_Missense_Mutation_p.V32I|NCF2_uc001gqk.3_Missense_Mutation_p.V32I	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	32					cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						GGGTCCTGGACGGCACTGAAG	0.557													0	0	0	0.01441	0	98	132										T	183559371	C	T	183559371	3	4	21	1	0	0	0	0	1	0	0	0	10217	536	19	2	1546	2	NCF2	1	183559371	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	23660935	183559371	65691250	6	6125										
TMEM63A	9725	broad.mit.edu	37	chr1	226044658	226044658	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gagtagtagacaatggagggGagcagggccgagaaggacca	18	6	0	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:226044658G>A	uc001hpm.1	-	16	1687	c.1437C>T	c.(1435-1437)CTC>CTT	p.L479L		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	479	Helical; (Potential).					integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					CAATGGAGGGGAGCAGGGCCG	0.597													0	0	0	0.016522	0	18	29										A	226044658	G	A	226044658	2	1	21	1	0	0	0	0	0	0	0	1	16187	1161	41	1		1	TMEM63A	1	226044658	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	42485287	226044658	23205963	7	6126										
KIF26B	55083	broad.mit.edu	37	chr1	245582982	245582982	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gcctgcagtgtcccagcctcGcagggctcctgcgtggccag	14	16	0	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr1:245582982G>T	uc001ibf.1	+	4	1541	c.1101G>T	c.(1099-1101)TCG>TCT	p.S367S	KIF26B_uc010pyq.1_Silent_p.S367S	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	367					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TCCCAGCCTCGCAGGGCTCCT	0.587													1	0	1.36615e-20	0.013726	1.51252e-20	34	94										T	245582982	G	T	245582982	2	4	21	1	0	0	0	0	0	0	0	1	8295	1074	38	4		4	KIF26B	1	245582982	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	19538324	245582982	3667639	8	6127										
TTC27	55622	broad.mit.edu	37	chr2	33007733	33007733	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tttgtcaacttcctatatccGattaaaacaaaagtaagtac	4	8	1	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr2:33007733G>T	uc002rom.2	+	15	2051	c.1820G>T	c.(1819-1821)CGA>CTA	p.R607L	TTC27_uc010ymx.1_Missense_Mutation_p.R557L|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	607	TPR 5.|HAT 2.						protein binding			central_nervous_system(1)	1						TCCTATATCCGATTAAAACAA	0.294													1	0	5.35267e-07	0.043863	5.53109e-07	17	20										T	33007733	G	T	33007733	3	4	21	1	0	0	0	0	1	0	0	0	16692	1058	37	3	1878	3	TTC27	2	33007733	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		33007733	210191640	9	6128										
SOS1	6654	broad.mit.edu	37	chr2	39250333	39250333	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	attgctagttgtttccccttCatttgctgactataaaaccg	6	10	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr2:39250333C>T	uc002rrk.3	-	10	1277	c.1236G>A	c.(1234-1236)ATG>ATA	p.M412I	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.M26I|SOS1_uc002rrl.2_Missense_Mutation_p.M144I	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	412					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				GTTTCCCCTTCATTTGCTGAC	0.353									Noonan_syndrome				0	0	0	0.041601	0	31	49										T	39250333	C	T	39250333	3	4	21	1	0	0	0	0	1	0	0	0	14936	826	29	1	2821	1	SOS1	2	39250333	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	6242600	39250333	203949040	10	6129										
ANKRD36B	57730	broad.mit.edu	37	chr2	98177186	98177186	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	atatttgaaacagaatctttGtcgtcacttgtagcctgaat	7	7	2	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr2:98177186G>C	uc010yvc.1	-	8	1087	c.807C>G	c.(805-807)GAC>GAG	p.D269E	ANKRD36B_uc010yve.1_RNA|ANKRD36B_uc010fif.2_RNA	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	ankyrin repeat domain 36B	269											0						CAGAATCTTTGTCGTCACTTG	0.323													0	0	0	0.037714	0	27	41										C	98177186	G	C	98177186	3	2	21	1	0	0	0	0	1	0	0	0	666	1368	48	4	3398	4	ANKRD36B	2	98177186	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	58926853	98177186	145022187	11	6130										
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tgggagaaattcacctgtctCttcatctagttgtaactgag	9	8	4	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr2:178098810C>T	uc002ulh.3	-	2	790	c.235G>A	c.(235-237)GAG>AAG	p.E79K	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63K|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63K|NFE2L2_uc002uli.3_Missense_Mutation_p.E63K|NFE2L2_uc010fra.2_Missense_Mutation_p.E63K|NFE2L2_uc010frb.2_Missense_Mutation_p.E63K	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.030466	0	41	40										T	178098810	C	T	178098810	3	4	21	1	0	0	0	0	1	0	0	0	10368	922	32	1	1598	1	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	79921624	178098810	65100563	12	6131										
ALS2CR12	130540	broad.mit.edu	37	chr2	202216040	202216040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	actccctgtggagttcttgcGtggtagttgaggggtcttga	15	7	2	2	rs143899839		TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr2:202216040G>A	uc010ftg.2	-	2	532	c.88C>T	c.(88-90)CGC>TGC	p.R30C	ALS2CR12_uc002uya.3_Missense_Mutation_p.R30C|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	30					regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GAGTTCTTGCGTGGTAGTTGA	0.517													0	0	0	0.016723	0	11	36										A	202216040	G	A	202216040	3	1	21	1	0	0	0	0	1	0	0	0	553	1145	40	2	1305	2	ALS2CR12	2	202216040	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	24117230	202216040	40983333	13	6132										
BSN	8927	broad.mit.edu	37	chr3	49690722	49690722	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gccaggctgctcagcctgccGcagagggcacgccagccagc	14	17	1	1	rs142148405		TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr3:49690722G>A	uc003cxe.3	+	5	3847	c.3733G>A	c.(3733-3735)GCA>ACA	p.A1245T		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1245					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCAGCCTGCCGCAGAGGGCAC	0.637													0	0	0	0.030466	0	41	67										A	49690722	G	A	49690722	3	1	21	1	0	0	0	0	1	0	0	0	1530	1087	38	2	3751	2	BSN	3	49690722	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		49690722	148331708	14	6133										
ARHGEF3	50650	broad.mit.edu	37	chr3	56807790	56807790	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ggccttcacgggcgggatgaGgtttgctagcgacgtgactc	16	10	1	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr3:56807790G>C	uc003dig.2	-	2	320	c.151C>G	c.(151-153)CTC>GTC	p.L51V	ARHGEF3_uc011bew.1_Missense_Mutation_p.L51V|ARHGEF3_uc003dih.2_Missense_Mutation_p.L83V|ARHGEF3_uc011bev.1_Missense_Mutation_p.L22V|ARHGEF3_uc003dif.2_Missense_Mutation_p.L57V|ARHGEF3_uc010hmy.1_5'UTR|ARHGEF3_uc003dii.2_Missense_Mutation_p.L51V	NM_019555	NP_062455	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor 3 isoform	51					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		GGCGGGATGAGGTTTGCTAGC	0.473													0	0	0	0.013726	0	28	10										C	56807790	G	C	56807790	3	2	21	1	0	0	0	0	1	0	0	0	904	1000	35	4	1465	4	ARHGEF3	3	56807790	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	7117068	56807790	141214640	15	6134										
PRR23B	389151	broad.mit.edu	37	chr3	138738758	138738758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	acggagggcgttccgggagcGgcgagcgcgcgtggggacct	21	11	0	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr3:138738758G>A	uc003esy.1	-	1	1011	c.746C>T	c.(745-747)CCG>CTG	p.P249L		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	249	Pro-rich.									breast(1)	1						TTCCGGGAGCGGCGAGCGCGC	0.672													0	0	0	0.009096	0	4	83										A	138738758	G	A	138738758	3	1	21	1	0	0	0	0	1	0	0	0	12595	1116	39	2	55	2	PRR23B	3	138738758	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	81930968	138738758	59283672	16	6135										
PCOLCE2	26577	broad.mit.edu	37	chr3	142567124	142567124	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tgccagctgtgttggcatcaGaaatcatctgcaccatcatc	8	12	4	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr3:142567124G>A	uc003evd.2	-	3	579	c.383C>T	c.(382-384)TCT>TTT	p.S128F		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	128	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GTTGGCATCAGAAATCATCTG	0.512													0	0	0	0.021022	0	39	61										A	142567124	G	A	142567124	3	1	21	1	0	0	0	0	1	0	0	0	11595	942	33	1	892	1	PCOLCE2	3	142567124	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	3828366	142567124	55455306	17	6136										
SKIL	6498	broad.mit.edu	37	chr3	170099114	170099114	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccatgtttctcagacacattCatttttacaccccaggtgag	6	12	2	2	rs140174204	by1000genomes	TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr3:170099114C>G	uc003fgu.2	+	3	1893	c.1181C>G	c.(1180-1182)TCA>TGA	p.S394*	SKIL_uc011bps.1_Nonsense_Mutation_p.S374*|SKIL_uc003fgv.2_Nonsense_Mutation_p.S394*|SKIL_uc003fgw.2_Nonsense_Mutation_p.S394*	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	394					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CAGACACATTCATTTTTACAC	0.284													0	0	0	0.041601	0	33	56										G	170099114	C	G	170099114	4	3	21	1	0	0	0	0	0	1	0	0	14358	838	29	1	1187	1	SKIL	3	170099114	Nonsense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	27531990	170099114	27923316	18	6137										
USP13	8975	broad.mit.edu	37	chr3	179462957	179462957	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cttctctgaaccagaaaatgTtgatgatttctggagcagtg	10	7	2	4			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr3:179462957T>C	uc003fkh.2	+	13	1742	c.1661T>C	c.(1660-1662)GTT>GCT	p.V554A	USP13_uc003fkf.2_Intron	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	554					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			CCAGAAAATGTTGATGATTTC	0.512													0	0	0	0.041601	0	31	58										C	179462957	T	C	179462957	3	2	21	1	0	0	0	0	1	0	0	0	17041	1725	60	5	1711	5	USP13	3	179462957	Missense_Mutation	SNP	T	TCGA-BT-A42B-01A-32D-A23M-08	9363843	179462957	18559473	19	6138										
TRIM2	23321	broad.mit.edu	37	chr4	154217081	154217081	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gaagaggcgcgttaagtcccCggggagcggccacgtcaagc	16	12	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr4:154217081C>T	uc003ing.2	+	6	1523	c.1322C>T	c.(1321-1323)CCG>CTG	p.P441L	TRIM2_uc003inh.2_Missense_Mutation_p.P468L	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	441						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		GTTAAGTCCCCGGGGAGCGGC	0.527													0	0	0	0.012213	0	33	41										T	154217081	C	T	154217081	3	4	21	1	0	0	0	0	1	0	0	0	16491	652	23	2	1425	2	TRIM2	4	154217081	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08		154217081	36937195	20	6139										
FAT1	2195	broad.mit.edu	37	chr4	187539564	187539564	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	agtcccactatgttctgctcGgatgagatctatctctgttc	8	11	3	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr4:187539564G>A	uc003izf.2	-	10	8364	c.8176C>T	c.(8176-8178)CGA>TGA	p.R2726*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2726	Extracellular (Potential).|Cadherin 25.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TGTTCTGCTCGGATGAGATCT	0.453										HNSCC(5;0.00058)			0	0	0	0.01441	0	56	101										A	187539564	G	A	187539564	4	1	21	1	0	0	0	0	0	1	0	0	5689	1124	39	2	5662	2	FAT1	4	187539564	Nonsense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	33322483	187539564	3614712	21	6140										
CDH10	1008	broad.mit.edu	37	chr5	24537588	24537588	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tttgatcacaaactctgactCtggctctactggcctcagag	8	12	5	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr5:24537588C>T	uc003jgr.1	-	3	759	c.427G>A	c.(427-429)GAG>AAG	p.E143K	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	143	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AACTCTGACTCTGGCTCTACT	0.423										HNSCC(23;0.051)			0	0	0	0.01441	0	62	109										T	24537588	C	T	24537588	3	4	21	1	0	0	0	0	1	0	0	0	3096	922	32	1	1979	1	CDH10	5	24537588	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08		24537588	156377672	22	6141										
HTR1A	3350	broad.mit.edu	37	chr5	63257179	63257179	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tggcgcacaggtgcaagatgGatgaggtgcagcacagcacg	16	9	0	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr5:63257179G>A	uc011cqt.1	-	1	368	c.368C>T	c.(367-369)TCC>TTC	p.S123F		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	123	Helical; Name=3; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GTGCAAGATGGATGAGGTGCA	0.642													0	0	0	0.01892	0	26	13										A	63257179	G	A	63257179	3	1	21	1	0	0	0	0	1	0	0	0	7436	1174	41	1	903	1	HTR1A	5	63257179	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	38719591	63257179	117658081	23	6142										
LCA5	167691	broad.mit.edu	37	chr6	80197346	80197346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	attcaaaatcaggtaacaatGgcaaaacagggtattttaga	8	5	2	1	rs139048294		TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr6:80197346G>A	uc003pix.2	-	8	1904	c.1469C>T	c.(1468-1470)CCA>CTA	p.P490L	LCA5_uc003piy.2_Missense_Mutation_p.P490L	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	490					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		AGGTAACAATGGCAAAACAGG	0.383													0	0	0	0.01441	0	66	108										A	80197346	G	A	80197346	3	1	21	1	0	0	0	0	1	0	0	0	8656	1348	47	2	628	2	LCA5	6	80197346	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		80197346	90917721	24	6143										
SSPO	23145	broad.mit.edu	37	chr7	149489805	149489805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccagtgccgtggcatccaccGcaaggcacgcaggtgctctg	13	15	1	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr7:149489805G>A	uc010lpk.2	+	39	5861	c.5861G>A	c.(5860-5862)CGC>CAC	p.R1954H		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1954	TSP type-1 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCATCCACCGCAAGGCACGC	0.687													0	0	0	0.016723	0	13	15										A	149489805	G	A	149489805	3	1	21	1	0	0	0	0	1	0	0	0	15188	1087	38	2	6007	2	SSPO	7	149489805	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		149489805	9648858	25	6144										
TNKS	8658	broad.mit.edu	37	chr8	9584174	9584174	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gtacacctatacgtacttctGatgttgattatcgactctta	6	9	2	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:9584174G>A	uc003wss.2	+	13	1950	c.1945G>A	c.(1945-1947)GAT>AAT	p.D649N	TNKS_uc011kww.1_Missense_Mutation_p.D412N|TNKS_uc010lrs.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	649					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		ACGTACTTCTGATGTTGATTA	0.363													0	0	0	0.01441	0	70	119										A	9584174	G	A	9584174	3	1	21	1	0	0	0	0	1	0	0	0	16316	1290	45	1	1995	1	TNKS	8	9584174	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		9584174	136779848	26	6145										
UNC5D	137970	broad.mit.edu	37	chr8	35608269	35608269	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttttggctgcatgtcctgtaActccctggattacaacttga	8	10	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:35608269A>G	uc003xjr.1	+	13	2433	c.2105A>G	c.(2104-2106)AAC>AGC	p.N702S	UNC5D_uc003xjs.1_Missense_Mutation_p.N697S|UNC5D_uc003xju.1_Missense_Mutation_p.N278S	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	702	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		ATGTCCTGTAACTCCCTGGAT	0.463													0	0	0	0.01441	0	66	114										G	35608269	A	G	35608269	3	3	21	1	0	0	0	0	1	0	0	0	16992	43	2	5	2155	5	UNC5D	8	35608269	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	26024095	35608269	110755753	27	6146										
PXDNL	137902	broad.mit.edu	37	chr8	52321370	52321370	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gcgcactcggtgggtgggccTgtagaaaagggcaataaggg	18	7	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:52321370T>C	uc003xqu.3	-	17	2915	c.2814A>G	c.(2812-2814)ACA>ACG	p.T938T	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	938					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGGGTGGGCCTGTAGAAAAGG	0.647													0	0	0	0.006214	0	9	39										C	52321370	T	C	52321370	2	2	21	1	0	0	0	0	0	0	0	1	12848	1567	55	5		5	PXDNL	8	52321370	Silent	SNP	T	TCGA-BT-A42B-01A-32D-A23M-08	16713101	52321370	94042652	28	6147										
HAS2	3037	broad.mit.edu	37	chr8	122626355	122626355	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	caaaacatggaagatcatacAtcaagcaccatgtcatattg	6	9	3	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:122626355A>T	uc003yph.2	-	4	2191	c.1653T>A	c.(1651-1653)GAT>GAA	p.D551E		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	551	Extracellular (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AAGATCATACATCAAGCACCA	0.443													0	0	0	0.01441	0	52	135										T	122626355	A	T	122626355	3	4	21	1	0	0	0	0	1	0	0	0	6962	214	8	5	9	5	HAS2	8	122626355	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	70304985	122626355	23737667	29	6148										
ATAD2	29028	broad.mit.edu	37	chr8	124382167	124382167	+	Missense_Mutation	SNP	A	A	T													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tcttcatcatcttcatcatcAtcatcatcatcatcatcgtc					rs149531312	byFrequency	TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:124382167A>T	uc003yqh.3	-	7	933	c.825T>A	c.(823-825)GAT>GAA	p.D275E	ATAD2_uc011lii.1_Missense_Mutation_p.D66E|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D275E	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	275	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			cttcatcatcatcatcatcat	0.179													0	0	0	0.004482	0	9	31										T	124382167	A	T	124382167	3	4	21	1	0	0	0	0	1	0	0	0	1071	214	8	5	3435	5	ATAD2	8	124382167	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	1755812	124382167	21981855	30	6149	28	2	1	19		3	2	28	N	A	6.715599e-05
ATAD2	29028	broad.mit.edu	37	chr8	124382176	124382176	+	Silent	SNP	A	A	G													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tcttcatcatcatcatcatcAtcatcatcgtcatcatcatc					rs148244463		TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:124382176A>G	uc003yqh.3	-	7	924	c.816T>C	c.(814-816)GAT>GAC	p.D272D	ATAD2_uc011lii.1_Silent_p.D63D|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Silent_p.D272D	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	272	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			catcatcatcatcatcatcgt	0.164													0	0	0	0.004482	0	8	29										G	124382176	A	G	124382176	2	3	21	1	0	0	0	0	0	0	0	1	1071	214	8	5		5	ATAD2	8	124382176	Silent	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	9	124382176	21981846	31	6150	28	2	1	19		3	2	28	N	A	6.715599e-05
ATAD2	29028	broad.mit.edu	37	chr8	124382194	124382194	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tcatcatcatcgtcatcatcAtcatcatcttcatcatcttc	1	14	12	0	rs140021846	byFrequency	TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:124382194A>T	uc003yqh.3	-	7	906	c.798T>A	c.(796-798)GAT>GAA	p.D266E	ATAD2_uc011lii.1_Missense_Mutation_p.D57E|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D266E	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	266	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			cgtcatcatcatcatcatctt	0.169													0	0	0	0.014758	0	4	42										T	124382194	A	T	124382194	3	4	21	1	0	0	0	0	1	0	0	0	1071	214	8	5	3462	5	ATAD2	8	124382194	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	18	124382194	21981828	32	6151			1	19		3	2	28	N	A	6.715599e-05
COL22A1	169044	broad.mit.edu	37	chr8	139606274	139606274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	actcacctttgggacctatgGgtccagagggtccttccaga	11	12	1	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr8:139606274G>A	uc003yvd.2	-	63	5048	c.4601C>T	c.(4600-4602)CCC>CTC	p.P1534L	COL22A1_uc011ljo.1_Missense_Mutation_p.P814L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1534	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGACCTATGGGTCCAGAGGG	0.652										HNSCC(7;0.00092)			0	0	0	0.019004	0	35	70										A	139606274	G	A	139606274	3	1	21	1	0	0	0	0	1	0	0	0	3681	1232	43	2	291	2	COL22A1	8	139606274	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	15224080	139606274	6757748	33	6152										
NFIL3	4783	broad.mit.edu	37	chr9	94172665	94172665	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	taattttagtgaaagcagctCagcttttaaagtggcgtttt	9	5	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr9:94172665C>G	uc004arh.2	-	2	747	c.352G>C	c.(352-354)GAG>CAG	p.E118Q		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	118	Leucine-zipper.				circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						GAAAGCAGCTCAGCTTTTAAA	0.393													0	0	0	0.01441	0	63	102										G	94172665	C	G	94172665	3	3	21	1	0	0	0	0	1	0	0	0	10373	835	29	1	1040	1	NFIL3	9	94172665	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08		94172665	47040766	34	6153										
SVEP1	79987	broad.mit.edu	37	chr9	113173859	113173859	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	taaccatcagagcagtagtaGaatgcaatgtctccaaagag	9	8	2	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr9:113173859G>C	uc010mtz.2	-	37	6469	c.6132C>G	c.(6130-6132)TTC>TTG	p.F2044L	SVEP1_uc010mty.2_5'UTR	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2044	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AGCAGTAGTAGAATGCAATGT	0.557													0	0	0	0.024245	0	15	27										C	113173859	G	C	113173859	3	2	21	1	0	0	0	0	1	0	0	0	15417	933	33	1	4631	1	SVEP1	9	113173859	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	19001194	113173859	28039572	35	6154										
ARHGAP22	58504	broad.mit.edu	37	chr10	49658321	49658321	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	taccttttcacactcctctcGtactcagtccgctggcggca	7	16	3	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr10:49658321G>C	uc001jgt.2	-	9	2148	c.1851C>G	c.(1849-1851)TAC>TAG	p.Y617*	ARHGAP22_uc001jgs.2_Nonsense_Mutation_p.Y527*|ARHGAP22_uc001jgu.2_Nonsense_Mutation_p.Y633*|ARHGAP22_uc010qgl.1_Nonsense_Mutation_p.Y574*|ARHGAP22_uc010qgm.1_Nonsense_Mutation_p.Y623*|ARHGAP22_uc001jgv.2_Nonsense_Mutation_p.Y315*|ARHGAP22_uc001jgr.2_Nonsense_Mutation_p.Y334*	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	617	Potential.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						CACTCCTCTCGTACTCAGTCC	0.687													0	0	0	0.024245	0	14	3										C	49658321	G	C	49658321	4	2	21	1	0	0	0	0	0	1	0	0	872	1140	40	4	253	4	ARHGAP22	10	49658321	Nonsense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		49658321	85876426	36	6155										
PCDH15	65217	broad.mit.edu	37	chr10	56077173	56077173	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tgagagtggtggtggtggttCgcctctcattcagattttgg	15	6	2	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr10:56077173C>T	uc001jju.1	-	8	1129	c.734G>A	c.(733-735)CGA>CAA	p.R245Q	PCDH15_uc010qhq.1_Missense_Mutation_p.R250Q|PCDH15_uc010qhr.1_Missense_Mutation_p.R245Q|PCDH15_uc010qhs.1_Missense_Mutation_p.R250Q|PCDH15_uc010qht.1_Missense_Mutation_p.R245Q|PCDH15_uc010qhu.1_Missense_Mutation_p.R245Q|PCDH15_uc001jjv.1_Missense_Mutation_p.R223Q|PCDH15_uc010qhv.1_Missense_Mutation_p.R245Q|PCDH15_uc010qhw.1_Missense_Mutation_p.R208Q|PCDH15_uc010qhx.1_Missense_Mutation_p.R245Q|PCDH15_uc010qhy.1_Missense_Mutation_p.R250Q|PCDH15_uc010qhz.1_Missense_Mutation_p.R245Q|PCDH15_uc010qia.1_Missense_Mutation_p.R223Q|PCDH15_uc010qib.1_Missense_Mutation_p.R223Q|PCDH15_uc001jjw.2_Missense_Mutation_p.R245Q	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	245	Extracellular (Potential).|Cadherin 2.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GGTGGTGGTTCGCCTCTCATT	0.413										HNSCC(58;0.16)			0	0	0	0.01441	0	60	19										T	56077173	C	T	56077173	3	4	21	1	0	0	0	0	1	0	0	0	11511	884	31	1	6881	1	PCDH15	10	56077173	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	6418852	56077173	79457574	37	6156										
FRG2B	441581	broad.mit.edu	37	chr10	135438800	135438800	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctgggcacacagaggcccccGgagccgagtgagcagtgtca	15	13	1	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr10:135438800G>A	uc010qvg.1	-	4	693	c.640C>T	c.(640-642)CGG>TGG	p.R214W		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	214						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AGAGGCCCCCGGAGCCGAGTG	0.582													0	0	0	0.030466	0	37	27										A	135438800	G	A	135438800	3	1	21	1	0	0	0	0	1	0	0	0	6047	1115	39	2	199	2	FRG2B	10	135438800	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	79361627	135438800	95947	38	6157										
MUC5B	727897	broad.mit.edu	37	chr11	1276413	1276414	+	Frame_Shift_Ins	INS	-	-	G													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cgactggcacaccccccactINSgccagccccgcagccccggt							TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr11:1276413_1276414insG	uc009ycr.1	+	58	16944_16945	c.16818_16819insG	c.(16816-16821)ACTGCCfs	p.T5606fs	MUC5B_uc001ltb.2_Frame_Shift_Ins_p.T5272fs	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5269_5270	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCCCCCACTGCCAGCCCCGC	0.673																		4	2	---	---								G	1276414	-	G	1276413	7	5	21	1	0	1	1	0	0	0	0	0	9979	1567	55	0	15958	0	MUC5B	11	1276413	Frame_Shift_Ins	INS	-	TCGA-BT-A42B-01A-32D-A23M-08		1276413	133730103	39	6158										
OR51A2	401667	broad.mit.edu	37	chr11	4976491	4976491	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	accaggagcatgctcttaaaGgagaatactatccctatttg	8	9	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr11:4976491G>T	uc010qyt.1	-	1	453	c.453C>A	c.(451-453)TCC>TCA	p.S151S		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTCTTAAAGGAGAATACTA	0.423													1	0	9.62906e-15	0.025465	1.04128e-14	35	97										T	4976491	G	T	4976491	2	4	21	1	0	0	0	0	0	0	0	1	11086	987	35	4		4	OR51A2	11	4976491	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	3700078	4976491	130030025	40	6159										
CST6	1474	broad.mit.edu	37	chr11	65780370	65780370	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccgcaagaccagggtcactgGagaccacgtcgacctcacca	10	16	2	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr11:65780370G>T	uc001ogr.2	+	2	368	c.314G>T	c.(313-315)GGA>GTA	p.G105V	CST6_uc001ogs.1_Missense_Mutation_p.G15V	NM_001323	NP_001314	Q15828	CYTM_HUMAN	cystatin M precursor	105					anatomical structure morphogenesis	extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1						AGGGTCACTGGAGACCACGTC	0.657													1	0	1.5739e-10	0.028581	1.68244e-10	17	30										T	65780370	G	T	65780370	3	4	21	1	0	0	0	0	1	0	0	0	3976	1174	41	3	320	3	CST6	11	65780370	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	60803879	65780370	69226146	41	6160										
ODZ4	26011	broad.mit.edu	37	chr11	78443573	78443573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctgtgtgatgaaaggtgcccGctcgaaccgcaggatgatgg	15	9	0	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr11:78443573G>A	uc001ozl.3	-	21	3389	c.2926C>T	c.(2926-2928)CGG>TGG	p.R976W		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	976	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						AAAGGTGCCCGCTCGAACCGC	0.542													0	0	0	0.020292	0	15	9										A	78443573	G	A	78443573	3	1	21	1	0	0	0	0	1	0	0	0	10837	1086	38	2	5439	2	ODZ4	11	78443573	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	12663203	78443573	56562943	42	6161										
MLL2	8085	broad.mit.edu	37	chr12	49420990	49421006	+	Frame_Shift_Del	DEL	GGGGAAGGGGGCGGGGA	GGGGAAGGGGGCGGGGA	-													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tggcaggagaaggtgccaagGgggaagggggcggggagggt							TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr12:49420990_49421006delGGGGAAGGGGGCGGGGA	uc001rta.3	-	48	14743_14759	c.14743_14759delTCCCCGCCCCCTTCCCC	c.(14743-14760)TCCCCGCCCCCTTCCCCCfs	p.S4915fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4915_4920	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGGTGCCAAGGGGGAAGGGGGCGGGGAGGGTTCTTCA	0.641			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								48	52	---	---								-	49421006	GGGGAAGGGGGCGGGGA	-	49420990	7	5	21	1	0	1	0	1	0	0	0	0	9621	1232	43	0	1882	0	MLL2	12	49420990	Frame_Shift_Del	DEL	GGGGAAGGGGGCGGGGA	TCGA-BT-A42B-01A-32D-A23M-08		49420990	84430905	43	6162										
AQP5	362	broad.mit.edu	37	chr12	50355840	50355840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccgtggccttcctcaaggccGtgttcgcagagttcttggcc	12	14	2	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr12:50355840G>A	uc001rvo.2	+	1	562	c.40G>A	c.(40-42)GTG>ATG	p.V14M		NM_001651	NP_001642	P55064	AQP5_HUMAN	aquaporin 5	14	Helical; (Potential).				carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity				0						CCTCAAGGCCGTGTTCGCAGA	0.428													0	0	0	0.043863	0	19	40										A	50355840	G	A	50355840	3	1	21	1	0	0	0	0	1	0	0	0	829	1145	40	2	42	2	AQP5	12	50355840	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	934850	50355840	83496055	44	6163										
C12orf42	374470	broad.mit.edu	37	chr12	103696166	103696166	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttccgacgggatttccggacGcgcccaggagtctgctttgg	14	12	1	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr12:103696166G>A	uc001tjt.2	-	6	891	c.803C>T	c.(802-804)GCG>GTG	p.A268V	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Missense_Mutation_p.A268V|C12orf42_uc001tju.2_Missense_Mutation_p.A173V	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	268										ovary(1)|central_nervous_system(1)	2						ATTTCCGGACGCGCCCAGGAG	0.667													0	0	0	0.01441	0	49	79										A	103696166	G	A	103696166	3	1	21	1	0	0	0	0	1	0	0	0	1688	1087	38	2	283	2	C12orf42	12	103696166	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	53340326	103696166	30155729	45	6164										
TMEM132D	121256	broad.mit.edu	37	chr12	129559351	129559351	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	atttaactttgatgtttgccGttccaacagctaacacactc	5	11	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr12:129559351G>A	uc009zyl.1	-	9	2697	c.2369C>T	c.(2368-2370)ACG>ATG	p.T790M	TMEM132D_uc001uia.2_Missense_Mutation_p.T328M	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	790	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GATGTTTGCCGTTCCAACAGC	0.483													0	0	0	0.017118	0	33	86										A	129559351	G	A	129559351	3	1	21	1	0	0	0	0	1	0	0	0	16044	1145	40	2	934	2	TMEM132D	12	129559351	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	25863185	129559351	4292544	46	6165										
LECT1	11061	broad.mit.edu	37	chr13	53313190	53313190	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctgtcgctccccttccagaaGtagaaggccccgatggcccc	10	17	0	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr13:53313190G>A	uc001vhf.2	-	2	300	c.189C>T	c.(187-189)TAC>TAT	p.Y63Y	LECT1_uc001vhg.2_Silent_p.Y63Y|LECT1_uc001vhh.2_Silent_p.Y90Y	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	63	Helical; (Potential).				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		CCTTCCAGAAGTAGAAGGCCC	0.652													0	0	0	0.038147	0	7	20										A	53313190	G	A	53313190	2	1	21	1	0	0	0	0	0	0	0	1	8712	1024	36	2		2	LECT1	13	53313190	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		53313190	61856688	47	6166										
TMCO3	55002	broad.mit.edu	37	chr13	114202741	114202741	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttgtcctggggagccgggcgCgaagagcgggcgtcatctct	17	11	2	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr13:114202741C>T	uc001vtu.3	+	12	2255	c.1894C>T	c.(1894-1896)CGA>TGA	p.R632*		NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	632						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GAGCCGGGCGCGAAGAGCGGG	0.652													0	0	0	0.01441	0	49	77										T	114202741	C	T	114202741	4	4	21	1	0	0	0	0	0	1	0	0	15994	760	27	2	1936	2	TMCO3	13	114202741	Nonsense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	60889551	114202741	967137	48	6167										
POTEG	404785	broad.mit.edu	37	chr14	19563461	19563461	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	agtatagtcagccttctactTgagcaaaacattgatgtatc	7	8	2	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr14:19563461T>A	uc001vuz.1	+	5	1027	c.975T>A	c.(973-975)CTT>CTA	p.L325L	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	325	ANK 5.									ovary(1)	1						GCCTTCTACTTGAGCAAAACA	0.358													0	0	0	0.023175	0	27	276										A	19563461	T	A	19563461	2	1	21	1	0	0	0	0	0	0	0	1	12266	1799	63	5		5	POTEG	14	19563461	Silent	SNP	T	TCGA-BT-A42B-01A-32D-A23M-08		19563461	87786079	49	6168										
SUPT16H	11198	broad.mit.edu	37	chr14	21829276	21829276	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gcttctcgagttttataacgTttctgtacttctttaataat	5	7	3	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr14:21829276T>C	uc001wao.2	-	16	2229	c.1890A>G	c.(1888-1890)AAA>AAG	p.K630K	SUPT16H_uc001wan.2_5'Flank	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	630					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TTTTATAACGTTTCTGTACTT	0.408													0	0	0	0.008871	0	19	113										C	21829276	T	C	21829276	2	2	21	1	0	0	0	0	0	0	0	1	15393	1722	60	5		5	SUPT16H	14	21829276	Silent	SNP	T	TCGA-BT-A42B-01A-32D-A23M-08	2265815	21829276	85520264	50	6169										
EFS	10278	broad.mit.edu	37	chr14	23828664	23828664	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccataaccaggcaggcggggTgggggtgggggcagaggccg	22	9	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr14:23828664T>G	uc001wjo.2	-	4	1631	c.1023A>C	c.(1021-1023)CCA>CCC	p.P341P	EFS_uc001wjp.2_Silent_p.P248P|EFS_uc010tnm.1_Silent_p.P172P	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	341	SH3-binding (Potential).|Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GCAGGCGGGGTGGGGGTGGGG	0.697													0	0	0	0.010504	0	14	63										G	23828664	T	G	23828664	2	3	21	1	0	0	0	0	0	0	0	1	4959	1683	59	5		5	EFS	14	23828664	Silent	SNP	T	TCGA-BT-A42B-01A-32D-A23M-08	1999388	23828664	83520876	51	6170										
NEO1	4756	broad.mit.edu	37	chr15	73593703	73593703	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cagtgaagacagcctccatcGggactctaggaaggagccgg	14	11	1	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr15:73593703G>A	uc002avm.3	+	28	4349	c.4207G>A	c.(4207-4209)GGG>AGG	p.G1403R	NEO1_uc010ukx.1_Missense_Mutation_p.G1392R|NEO1_uc010uky.1_Missense_Mutation_p.G1350R|NEO1_uc010ukz.1_Missense_Mutation_p.G816R|NEO1_uc002avn.3_Missense_Mutation_p.G1041R	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	1403	Cytoplasmic (Potential).				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						AGCCTCCATCGGGACTCTAGG	0.557													0	0	0	0.004672	0	3	36										A	73593703	G	A	73593703	3	1	21	1	0	0	0	0	1	0	0	0	10336	1116	39	2	4317	2	NEO1	15	73593703	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		73593703	28937689	52	6171										
ZNF710	374655	broad.mit.edu	37	chr15	90611415	90611415	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gctgacgcaccagggcacccGgccccacaagtgccaggtat	12	16	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr15:90611415G>A	uc002bov.1	+	2	1169	c.1046G>A	c.(1045-1047)CGG>CAG	p.R349Q		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			CAGGGCACCCGGCCCCACAAG	0.642													0	0	0	0.01441	0	71	35										A	90611415	G	A	90611415	3	1	21	1	0	0	0	0	1	0	0	0	18112	1116	39	2	1048	2	ZNF710	15	90611415	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	17017712	90611415	11919977	53	6172										
RNPS1	10921	broad.mit.edu	37	chr16	2304013	2304013	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctcctgtggcggcggcggccCggggaccgtgatctccggcg	18	15	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:2304013C>T	uc002cpt.2	-	8	1416	c.870G>A	c.(868-870)CCG>CCA	p.P290P	DCI_uc002cpr.2_5'Flank|DCI_uc002cps.2_5'Flank|RNPS1_uc002cpu.2_Silent_p.P290P|RNPS1_uc002cpv.2_Silent_p.P113P|RNPS1_uc002cpw.2_Silent_p.P290P|RNPS1_uc002cpx.2_Silent_p.P267P|RNPS1_uc010uwa.1_RNA	NM_080594	NP_542161	Q15287	RNPS1_HUMAN	RNA-binding protein S1, serine-rich domain	290	Necessary for interaction with TRA2B, nuclear localization and exon-skipping.|Arg/Pro-rich.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(1)	1						GGCGGCGGCCCGGGGACCGTG	0.657													0	0	0	0.014758	0	4	8										T	2304013	C	T	2304013	2	4	21	1	0	0	0	0	0	0	0	1	13511	639	23	2		2	RNPS1	16	2304013	Silent	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08		2304013	88050740	54	6173										
CIITA	4261	broad.mit.edu	37	chr16	11001758	11001758	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cagccggggacactgcgggcGcggcagctgctggagctgct	18	13	0	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:11001758G>A	uc002dai.3	+	11	2542	c.2409G>A	c.(2407-2409)GCG>GCA	p.A803A	CIITA_uc002daj.3_Silent_p.A804A|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Silent_p.A803A|CIITA_uc002dah.2_Silent_p.A755A|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	803					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						CACTGCGGGCGCGGCAGCTGC	0.682			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								0	0	0	0.045705	0	34	24										A	11001758	G	A	11001758	2	1	21	1	0	0	0	0	0	0	0	1	3428	1074	38	2		2	CIITA	16	11001758	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	8697745	11001758	79352995	55	6174										
ABCC1	4363	broad.mit.edu	37	chr16	16230365	16230365	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tgttttcgggttccctccgaAtgaacctggacccattcagc	9	13	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:16230365A>G	uc010bvi.2	+	29	4331	c.4156A>G	c.(4156-4158)ATG>GTG	p.M1386V	ABCC1_uc010bvj.2_Missense_Mutation_p.M1327V|ABCC1_uc010bvk.2_Missense_Mutation_p.M1330V|ABCC1_uc010bvl.2_Missense_Mutation_p.M1386V|ABCC1_uc010bvm.2_Missense_Mutation_p.M1271V|ABCC1_uc002del.3_Missense_Mutation_p.M1280V	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1386	ABC transporter 2.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCCCTCCGAATGAACCTGGA	0.552													0	0	0	0.013537	0	10	25										G	16230365	A	G	16230365	3	3	21	1	0	0	0	0	1	0	0	0	49	101	4	5	4270	5	ABCC1	16	16230365	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	5228607	16230365	74124388	56	6175										
SLC5A11	115584	broad.mit.edu	37	chr16	24902200	24902200	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tgaattctaggttttgccgcGgttggtgggatggaaggact	16	5	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:24902200G>A	uc002dmu.2	+	9	907	c.675G>A	c.(673-675)GCG>GCA	p.A225A	SLC5A11_uc002dms.2_Silent_p.A161A|SLC5A11_uc010vcd.1_Silent_p.A190A|SLC5A11_uc002dmt.2_Intron|SLC5A11_uc010vce.1_Silent_p.A155A|SLC5A11_uc010bxt.2_Silent_p.A161A	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	225	Helical; (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		GTTTTGCCGCGGTTGGTGGGA	0.542													0	0	0	0.01441	0	98	159										A	24902200	G	A	24902200	2	1	21	1	0	0	0	0	0	0	0	1	14663	1103	39	2		2	SLC5A11	16	24902200	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	8671835	24902200	65452553	57	6176										
MVP	9961	broad.mit.edu	37	chr16	29852959	29852959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cctacatgctgacccaggacGaagtcctgtgggagaaagag	13	10	0	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:29852959G>A	uc002dui.2	+	9	1318	c.1234G>A	c.(1234-1236)GAA>AAA	p.E412K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.E412K|MVP_uc010vea.1_Missense_Mutation_p.E6K	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	412	MVP 8.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GACCCAGGACGAAGTCCTGTG	0.617													0	0	0	0.043863	0	20	18										A	29852959	G	A	29852959	3	1	21	1	0	0	0	0	1	0	0	0	9996	1059	37	1	1264	1	MVP	16	29852959	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	4950759	29852959	60501794	58	6177										
DOC2A	8448	broad.mit.edu	37	chr16	30017613	30017613	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ggcagtcactccagtgcttcCgagcctcgcctcgggcacct	11	17	1	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:30017613C>A	uc002dvm.2	-	11	1197	c.1097G>T	c.(1096-1098)CGG>CTG	p.R366L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Missense_Mutation_p.R364L|DOC2A_uc002dvn.2_Missense_Mutation_p.R366L|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Missense_Mutation_p.R366L|DOC2A_uc002dvp.2_Missense_Mutation_p.R366L|DOC2A_uc002dvq.2_Missense_Mutation_p.R366L	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	366	Interaction with UNC13D.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						CCAGTGCTTCCGAGCCTCGCC	0.721													1	0	3.32936e-07	0.038395	3.47899e-07	19	23										A	30017613	C	A	30017613	3	1	21	1	0	0	0	0	1	0	0	0	4683	652	23	4	109	4	DOC2A	16	30017613	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	164654	30017613	60337140	59	6178										
ITGAD	3681	broad.mit.edu	37	chr16	31425842	31425842	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctgacttctcgtgccattttCaatgaaaccaagaaccccac	5	14	2	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr16:31425842C>T	uc002ebv.1	+	17	2116	c.2067C>T	c.(2065-2067)TTC>TTT	p.F689F	ITGAD_uc010cap.1_Silent_p.F690F	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	689	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GTGCCATTTTCAATGAAACCA	0.493													0	0	0	0.01441	0	171	296										T	31425842	C	T	31425842	2	4	21	1	0	0	0	0	0	0	0	1	7884	825	29	1		1	ITGAD	16	31425842	Silent	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	1408229	31425842	58928911	60	6179										
YWHAE	7531	broad.mit.edu	37	chr17	1268269	1268270	+	Nonsense_Mutation	DNP	TA	TA	AT													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tctagctccaatcacattctTatatgcaacagataggaggt							TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr17:1268269_1268270TA>AT	uc002fsj.2	-	2	299_300	c.147_148TA>AT	c.(145-150)TATAAG>TAATAG	p.49_50YK>**	YWHAE_uc002fsk.2_Nonsense_Mutation_p.27_28YK>**|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_RNA	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	49_50					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding	p.Y49C(1)		lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		ATCACATTCTTATATGCAACAG	0.411													0	0	0	0.004672	0	10	153										AT	1268270	TA	AT	1268269	4	1	21	1	0	0	0	0	0	1	0	0	17499	1763	61	5	639	5	YWHAE	17	1268269	Nonsense_Mutation	DNP	TA	TCGA-BT-A42B-01A-32D-A23M-08		1268269	79926941	61	6180										
ADAM11	4185	broad.mit.edu	37	chr17	42854950	42854950	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gtgtcaccttctaccaccagGgcaaggagctggactgcagg	13	12	2	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr17:42854950G>A	uc002ihh.2	+	22	1882	c.1882G>A	c.(1882-1884)GGC>AGC	p.G628S	ADAM11_uc010wjd.1_Missense_Mutation_p.G428S|ADAM11_uc002ihi.2_5'UTR	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	628	Cys-rich.|Extracellular (Potential).				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				CTACCACCAGGGCAAGGAGCT	0.617													0	0	0	0.01441	0	57	116										A	42854950	G	A	42854950	3	1	21	1	0	0	0	0	1	0	0	0	235	1232	43	2	1968	2	ADAM11	17	42854950	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	41586681	42854950	38340260	62	6181										
CACNA1A	773	broad.mit.edu	37	chr19	13409700	13409700	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctcgctcggcctcgccctccCagaacccgggttgctccagg	11	19	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:13409700C>T	uc010dze.2	-	19	2986	c.2750G>A	c.(2749-2751)TGG>TAG	p.W917*	CACNA1A_uc010dzc.2_Nonsense_Mutation_p.W442*|CACNA1A_uc002mwy.3_Nonsense_Mutation_p.W916*|CACNA1A_uc010xne.1_Nonsense_Mutation_p.W445*	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	917	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CTCGCCCTCCCAGAACCCGGG	0.771													0	0	0	0.043863	0	17	22										T	13409700	C	T	13409700	4	4	21	1	0	0	0	0	0	1	0	0	2538	595	21	2	4991	2	CACNA1A	19	13409700	Nonsense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08		13409700	45719283	63	6182										
NWD1	284434	broad.mit.edu	37	chr19	16860863	16860863	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ctcatcctctcagcttgctcGggggcactgggggttttgga	14	11	2	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:16860863G>A	uc002neu.3	+	6	1832	c.1410G>A	c.(1408-1410)TCG>TCA	p.S470S	NWD1_uc002net.3_Silent_p.S335S|NWD1_uc002nev.3_Silent_p.S264S			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	470	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CAGCTTGCTCGGGGGCACTGG	0.632													0	0	0	0.01441	0	51	105										A	16860863	G	A	16860863	2	1	21	1	0	0	0	0	0	0	0	1	10781	1103	39	2		2	NWD1	19	16860863	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	3451163	16860863	42268120	64	6183										
GMIP	51291	broad.mit.edu	37	chr19	19745888	19745888	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gtgcacttcgtgaccacaaaGggtacctcctccgggaagtc	11	13	0	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:19745888G>A	uc002nnd.2	-	16	1812	c.1695C>T	c.(1693-1695)CCC>CCT	p.P565P	GMIP_uc010xrb.1_Silent_p.P539P|GMIP_uc010xrc.1_Silent_p.P536P	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	565	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						TGACCACAAAGGGTACCTCCT	0.597													0	0	0	0.017118	0	37	80										A	19745888	G	A	19745888	2	1	21	1	0	0	0	0	0	0	0	1	6491	987	35	2		2	GMIP	19	19745888	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	2885025	19745888	39383095	65	6184										
RHPN2	85415	broad.mit.edu	37	chr19	33517486	33517486	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	catctgcaggtctgagttgaCgaagctcagctccagccgca	11	13	3	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:33517486C>T	uc002nuf.2	-	3	304	c.238G>A	c.(238-240)GTC>ATC	p.V80I	RHPN2_uc010xro.1_5'UTR|RHPN2_uc002nue.2_5'UTR	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	80	REM.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					TCTGAGTTGACGAAGCTCAGC	0.562													0	0	0	0.01441	0	62	89										T	33517486	C	T	33517486	3	4	21	1	0	0	0	0	1	0	0	0	13351	536	19	2	1874	2	RHPN2	19	33517486	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	13771598	33517486	25611497	66	6185										
RYR1	6261	broad.mit.edu	37	chr19	39026668	39026668	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tcaatgcctttgagagacagAacaaggccgaggggctgggc	15	9	1	3			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:39026668A>C	uc002oit.2	+	82	11678	c.11548A>C	c.(11548-11550)AAC>CAC	p.N3850H	RYR1_uc002oiu.2_Missense_Mutation_p.N3845H|RYR1_uc002oiv.1_Missense_Mutation_p.N765H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3850					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGAGAGACAGAACAAGGCCGA	0.577													0	0	0	0.004482	0	8	15										C	39026668	A	C	39026668	3	2	21	1	0	0	0	0	1	0	0	0	13768	246	9	5	11874	5	RYR1	19	39026668	Missense_Mutation	SNP	A	TCGA-BT-A42B-01A-32D-A23M-08	5509182	39026668	20102315	67	6186										
PRR12	57479	broad.mit.edu	37	chr19	50117814	50117814	+	Frame_Shift_Del	DEL	C	C	-													0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	cgttgcagacggggcgtgaaCccccacccatctggcgagtc							TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:50117814delC	uc002poo.3	+	7	4798	c.4798delC	c.(4798-4800)CCCfs	p.P1600fs		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	779							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGGCGTGAACCCCCACCCAT	0.612																		2	4	---	---								-	50117814	C	-	50117814	7	5	21	1	0	1	0	1	0	0	0	0	12584	507	18	0	4824	0	PRR12	19	50117814	Frame_Shift_Del	DEL	C	TCGA-BT-A42B-01A-32D-A23M-08	11091146	50117814	9011169	68	6187										
MYBPC2	4606	broad.mit.edu	37	chr19	50939408	50939408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttcaaggagtcccacaactcCgccagcaatgtgaggacccc	9	15	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:50939408C>T	uc002psf.2	+	4	387	c.336C>T	c.(334-336)TCC>TCT	p.S112S		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	112	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CCCACAACTCCGCCAGCAATG	0.607													0	0	0	0.009096	0	3	10										T	50939408	C	T	50939408	2	4	21	1	0	0	0	0	0	0	0	1	10012	639	23	2		2	MYBPC2	19	50939408	Silent	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	821594	50939408	8189575	69	6188										
EPN1	29924	broad.mit.edu	37	chr19	56200276	56200276	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tcaggcccccctcccgaggcGgagcaggcgtggccgcagag	16	16	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr19:56200276G>A	uc002qlw.2	+	4	861	c.519G>A	c.(517-519)GCG>GCA	p.A173A	EPN1_uc002qlv.2_Silent_p.A173A|EPN1_uc010etd.2_Silent_p.A173A|EPN1_uc002qlx.2_Silent_p.A284A	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	173					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CTCCCGAGGCGGAGCAGGCGT	0.692													0	0	0	0.021553	0	5	6										A	56200276	G	A	56200276	2	1	21	1	0	0	0	0	0	0	0	1	5185	1103	39	2		2	EPN1	19	56200276	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	5260868	56200276	2928707	70	6189										
SGK2	10110	broad.mit.edu	37	chr20	42204997	42204997	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ccacaaggaccagaggcagcGgctgggctccaaagcagact	13	13	0	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr20:42204997G>A	uc002xkv.2	+	10	1226	c.1007G>A	c.(1006-1008)CGG>CAG	p.R336Q	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.R276Q|SGK2_uc010ggm.2_Missense_Mutation_p.R276Q|SGK2_uc002xks.2_Missense_Mutation_p.R275Q|SGK2_uc002xku.2_Missense_Mutation_p.R276Q	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	336	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAGAGGCAGCGGCTGGGCTCC	0.602													0	0	0	0.017118	0	36	62										A	42204997	G	A	42204997	3	1	21	1	0	0	0	0	1	0	0	0	14209	1116	39	2	1045	2	SGK2	20	42204997	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08		42204997	20820523	71	6190										
PRIC285	85441	broad.mit.edu	37	chr20	62200824	62200824	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	accggccggcggccaaagtcGaagaccacccattgctcaaa	10	15	1	1	rs143216041		TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr20:62200824G>A	uc002yfm.2	-	5	1657	c.765C>T	c.(763-765)TTC>TTT	p.F255F	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	255					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGCCAAAGTCGAAGACCACCC	0.677													0	0	0	0.016522	0	22	30										A	62200824	G	A	62200824	2	1	21	1	0	0	0	0	0	0	0	1	12485	1049	37	1		1	PRIC285	20	62200824	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	19995827	62200824	824696	72	6191										
ARFRP1	10139	broad.mit.edu	37	chr20	62338384	62338384	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttgtccaggcccaggatcagGatgcagtactcgtccttctg	11	12	2	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chr20:62338384G>A	uc002yga.2	-	1	627	c.60C>T	c.(58-60)ATC>ATT	p.I20I	ARFRP1_uc002ygc.2_Silent_p.I20I|ARFRP1_uc002ygh.3_Silent_p.I20I|ARFRP1_uc011abf.1_Silent_p.I20I|ARFRP1_uc011abg.1_Silent_p.I20I|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Silent_p.I20I|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	20					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CCAGGATCAGGATGCAGTACT	0.607													0	0	0	0.030593	0	28	34										A	62338384	G	A	62338384	2	1	21	1	0	0	0	0	0	0	0	1	856	1164	41	1		1	ARFRP1	20	62338384	Silent	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	137560	62338384	687136	73	6192										
ZMYM3	9203	broad.mit.edu	37	chrX	70471085	70471085	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	ttctgctctcctaacgcgctCgcttctcttctgtacctcgg	7	16	4	0			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chrX:70471085C>A	uc004dzh.1	-	4	808	c.721G>T	c.(721-723)GAG>TAG	p.E241*	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Nonsense_Mutation_p.E241*|ZMYM3_uc004dzj.1_Nonsense_Mutation_p.E241*|ZMYM3_uc011mpu.1_5'UTR|ZMYM3_uc004dzk.3_Nonsense_Mutation_p.E241*|ZMYM3_uc004dzl.3_Nonsense_Mutation_p.E241*|ZMYM3_uc004dzm.3_Nonsense_Mutation_p.E241*	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	241					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTAACGCGCTCGCTTCTCTTC	0.527													1	0	1.99505e-19	0.012213	2.18282e-19	32	8										A	70471085	C	A	70471085	4	1	21	1	0	0	0	0	0	1	0	0	17698	893	31	3	3497	3	ZMYM3	23	70471085	Nonsense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08		70471085	84799475	74	6193										
MAGT1	84061	broad.mit.edu	37	chrX	77112890	77112890	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tcggcgatccaccgggcaatCtgctcagctgaaaaaccccg	10	15	2	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chrX:77112890C>T	uc004fof.2	-	4	653	c.591G>A	c.(589-591)CAG>CAA	p.Q197Q	MAGT1_uc004fog.3_Intron	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	165					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						ACCGGGCAATCTGCTCAGCTG	0.463													0	0	0	0.01441	0	75	19										T	77112890	C	T	77112890	2	4	21	1	0	0	0	0	0	0	0	1	9196	912	32	1		1	MAGT1	23	77112890	Silent	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	6641805	77112890	78157670	75	6194										
DIAPH2	1730	broad.mit.edu	37	chrX	96354743	96354743	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	atactcaacgaattagcagaGcttaagaatgaatatgatga	8	5	1	5			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chrX:96354743G>C	uc004efu.3	+	20	2694	c.2298G>C	c.(2296-2298)GAG>GAC	p.E766D	DIAPH2_uc004eft.3_Missense_Mutation_p.E766D	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	766	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						AATTAGCAGAGCTTAAGAATG	0.358													0	0	0	0.01892	0	22	4										C	96354743	G	C	96354743	3	2	21	1	0	0	0	0	1	0	0	0	4519	962	34	4	2376	4	DIAPH2	23	96354743	Missense_Mutation	SNP	G	TCGA-BT-A42B-01A-32D-A23M-08	19241853	96354743	58915817	76	6195										
PAK3	5063	broad.mit.edu	37	chrX	110439847	110439847	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	gtggaaggtgaacccccttaCcttaatgaaaatccactcag	8	11	1	2			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chrX:110439847C>T	uc004epa.2	+	13	1458	c.1431C>T	c.(1429-1431)TAC>TAT	p.Y477Y	PAK3_uc010npt.1_Silent_p.Y462Y|PAK3_uc010npu.1_Silent_p.Y462Y|PAK3_uc004eoy.1_Silent_p.Y217Y|PAK3_uc004eoz.2_Silent_p.Y462Y|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Silent_p.Y498Y|PAK3_uc010npw.1_Silent_p.Y483Y	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	477	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						AACCCCCTTACCTTAATGAAA	0.438										TSP Lung(19;0.15)			0	0	0	0.014323	0	21	43										T	110439847	C	T	110439847	2	4	21	1	0	0	0	0	0	0	0	1	11402	518	18	2		2	PAK3	23	110439847	Silent	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	14085104	110439847	44830713	77	6196										
MAGEA12	4111	broad.mit.edu	37	chrX	151900051	151900051	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.12987012987013	10	0.114834338020845	1.55467847516365	3.08992346938776	1.28174603174603	0.178895407997576	0.323005597773401	0	tccaggtagttttcctgcacCaaatcttgggtgagcagctt	10	10	1	1			TCGA-BT-A42B-01A-32D-A23M-08	TCGA-BT-A42B-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	316411ea-2e0b-494a-b3a9-ce8225140e32	791afb2c-5644-4d7e-8c0b-249c53d4e64a	g.chrX:151900051C>G	uc010ntp.2	-	3	1104	c.750G>C	c.(748-750)TTG>TTC	p.L250F	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.L250F	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	250	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCTGCACCAAATCTTGGG	0.567													0	0	0	0.041601	0	32	104										G	151900051	C	G	151900051	3	3	21	1	0	0	0	0	1	0	0	0	9166	593	21	4	198	4	MAGEA12	23	151900051	Missense_Mutation	SNP	C	TCGA-BT-A42B-01A-32D-A23M-08	41460204	151900051	3370509	78	6197										
CAMTA1	23261	broad.mit.edu	37	chr1	7723702	7723702	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctgtgtccatcagcagcggGctcaacagcgacccggacat	11	15	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:7723702G>A	uc001aoi.2	+	9	1302	c.1095G>A	c.(1093-1095)GGG>GGA	p.G365G		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCAGCAGCGGGCTCAACAGCG	0.662													0	0	0	0.010729	0	12	126										A	7723702	G	A	7723702	2	1	22	1	0	0	0	0	0	0	0	1	2613	1190	42	2		2	CAMTA1	1	7723702	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08		7723702	241526919	1	6198										
PER3	8863	broad.mit.edu	37	chr1	7863866	7863866	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagctttgtgaatccctggaGccggaagatttctttcatca	9	10	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:7863866G>T	uc001aoo.2	+	9	1266	c.1091G>T	c.(1090-1092)AGC>ATC	p.S364I	PER3_uc009vmg.1_Missense_Mutation_p.S365I|PER3_uc009vmh.1_Missense_Mutation_p.S365I|PER3_uc001aop.2_Missense_Mutation_p.S365I|PER3_uc010nzw.1_Missense_Mutation_p.S46I|PER3_uc001aon.2_Missense_Mutation_p.S364I	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	364	PAC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		AATCCCTGGAGCCGGAAGATT	0.403													1	0	1.36161e-19	0.004289	1.53322e-19	36	41										T	7863866	G	T	7863866	3	4	22	1	0	0	0	0	1	0	0	0	11731	971	34	4	1125	4	PER3	1	7863866	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	140164	7863866	241386755	2	6199										
RERE	473	broad.mit.edu	37	chr1	8617577	8617577	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttcatgaggagatggtccctCttactctgaaaaggaaaatc	9	8	3	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:8617577C>G	uc001ape.2	-	6	1338	c.528G>C	c.(526-528)AAG>AAC	p.K176N	RERE_uc001apf.2_Missense_Mutation_p.K176N|RERE_uc001aph.1_Missense_Mutation_p.K176N	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	176	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GATGGTCCCTCTTACTCTGAA	0.438													0	0	0	0.012319	0	22	30										G	8617577	C	G	8617577	3	3	22	1	0	0	0	0	1	0	0	0	13231	912	32	1	4248	1	RERE	1	8617577	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	753711	8617577	240633044	3	6200										
DFFA	1676	broad.mit.edu	37	chr1	10523593	10523593	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tctttggtcaagcacctgttGgagtgtgtgctgcagccgct	13	10	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:10523593G>T	uc001arj.2	-	4	624	c.526C>A	c.(526-528)CAA>AAA	p.Q176K	DFFA_uc001ark.2_Missense_Mutation_p.Q176K	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	176					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGCACCTGTTGGAGTGTGTGC	0.547													1	0	3.61848e-18	0.007835	4.05776e-18	40	167										T	10523593	G	T	10523593	3	4	22	1	0	0	0	0	1	0	0	0	4452	1357	47	4	505	4	DFFA	1	10523593	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1906016	10523593	238727028	4	6201										
C1orf127	148345	broad.mit.edu	37	chr1	11017751	11017751	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atgtccacatacagtcccatCaggctggcgtcttcaagaga	9	12	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:11017751C>T	uc010oao.1	-	3	173	c.168G>A	c.(166-168)CTG>CTA	p.L56L	C1orf127_uc001arr.1_Silent_p.L56L|C1orf127_uc001ars.1_Silent_p.L56L	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	56										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		ACAGTCCCATCAGGCTGGCGT	0.582													0	0	0	0.00361	0	62	83										T	11017751	C	T	11017751	2	4	22	1	0	0	0	0	0	0	0	1	1994	813	29	1		1	C1orf127	1	11017751	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	494158	11017751	238232870	5	6202										
SPEN	23013	broad.mit.edu	37	chr1	16203049	16203049	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	attcatcccagtctagaaatCagtctcctcagagactggct	7	12	5	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:16203049C>G	uc001axk.1	+	3	961	c.757C>G	c.(757-759)CAG>GAG	p.Q253E	SPEN_uc010obp.1_Missense_Mutation_p.Q212E	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	253	Ser-rich.|Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTCTAGAAATCAGTCTCCTCA	0.537													0	0	0	0.005524	0	33	90										G	16203049	C	G	16203049	3	3	22	1	0	0	0	0	1	0	0	0	15037	827	29	1	767	1	SPEN	1	16203049	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5185298	16203049	233047572	6	6203										
SPEN	23013	broad.mit.edu	37	chr1	16260122	16260130	+	In_Frame_Del	DEL	AGCGATCCA	AGCGATCCA	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgacccggtgaccccacccAgcgatccaagcatccccata							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:16260122_16260130delAGCGATCCA	uc001axk.1	+	11	7591_7599	c.7387_7395delAGCGATCCA	c.(7387-7395)AGCGATCCAdel	p.SDP2463del	SPEN_uc010obp.1_In_Frame_Del_p.SDP2422del	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2463_2465	RID.|Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GACCCCACCCAGCGATCCAAGCATCCCCA	0.603																		12	117	---	---								-	16260130	AGCGATCCA	-	16260122	7	5	22	1	0	1	0	1	0	0	0	0	15037	188	7	0	7429	0	SPEN	1	16260122	In_Frame_Del	DEL	AGCGATCCA	TCGA-BT-A42C-01A-11D-A23M-08	57073	16260122	232990499	7	6204										
LUZP1	7798	broad.mit.edu	37	chr1	23419953	23419953	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttgtttcttgtttcattctCtacctgctttaggtagtcca	6	9	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:23419953C>T	uc001bgk.2	-	4	1186	c.802G>A	c.(802-804)GAG>AAG	p.E268K	LUZP1_uc010odv.1_Missense_Mutation_p.E268K|LUZP1_uc001bgl.2_Missense_Mutation_p.E268K|LUZP1_uc001bgm.1_Missense_Mutation_p.E268K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	268	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		GTTTCATTCTCTACCTGCTTT	0.413													0	0	0	0.010818	0	32	51										T	23419953	C	T	23419953	3	4	22	1	0	0	0	0	1	0	0	0	9086	922	32	1	2436	1	LUZP1	1	23419953	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	7159831	23419953	225830668	8	6205										
LUZP1	7798	broad.mit.edu	37	chr1	23420139	23420139	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttttatcaatttctcattttCtttctccttttcattcaagt	1	9	6	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:23420139C>G	uc001bgk.2	-	4	1000	c.616G>C	c.(616-618)GAA>CAA	p.E206Q	LUZP1_uc010odv.1_Missense_Mutation_p.E206Q|LUZP1_uc001bgl.2_Missense_Mutation_p.E206Q|LUZP1_uc001bgm.1_Missense_Mutation_p.E206Q	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	206	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTCTCATTTTCTTTCTCCTTT	0.328													0	0	0	0.007413	0	20	29										G	23420139	C	G	23420139	3	3	22	1	0	0	0	0	1	0	0	0	9086	922	32	1	2622	1	LUZP1	1	23420139	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	186	23420139	225830482	9	6206										
ASAP3	55616	broad.mit.edu	37	chr1	23763091	23763091	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggtttagggccgccgtgtgaGggtagctgggcctccatgac	17	10	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:23763091G>A	uc001bha.2	-	16	1657	c.1533C>T	c.(1531-1533)CCC>CCT	p.P511P	ASAP3_uc001bgy.1_Silent_p.P15P|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Silent_p.P380P|ASAP3_uc010oea.1_Silent_p.P502P|ASAP3_uc001bhb.2_Silent_p.P34P	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	511	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CGCCGTGTGAGGGTAGCTGGG	0.587													0	0	0	0.00361	0	56	70										A	23763091	G	A	23763091	2	1	22	1	0	0	0	0	0	0	0	1	1012	987	35	2		2	ASAP3	1	23763091	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	342952	23763091	225487530	10	6207										
ZNF683	257101	broad.mit.edu	37	chr1	26691249	26691249	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gggaaggcagagcttggccaGaggcttggaaggcccctggg	19	9	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:26691249G>A	uc001bmg.1	-	4	906	c.788C>T	c.(787-789)TCT>TTT	p.S263F	ZNF683_uc001bmh.1_Missense_Mutation_p.S263F|ZNF683_uc009vsj.1_Missense_Mutation_p.S263F	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		AGCTTGGCCAGAGGCTTGGAA	0.642													0	0	0	0.00361	0	58	48										A	26691249	G	A	26691249	3	1	22	1	0	0	0	0	1	0	0	0	18087	942	33	1	738	1	ZNF683	1	26691249	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2928158	26691249	222559372	11	6208										
FCN3	8547	broad.mit.edu	37	chr1	27699711	27699711	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cacagatggtaccagccgctCaaggtggcgccctggctcaa	12	14	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:27699711C>G	uc001boa.2	-	5	315	c.309G>C	c.(307-309)TTG>TTC	p.L103F	FCN3_uc001bob.2_Missense_Mutation_p.L92F	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	103	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCAGCCGCTCAAGGTGGCGC	0.642													0	0	0	0.003271	0	34	71										G	27699711	C	G	27699711	3	3	22	1	0	0	0	0	1	0	0	0	5793	825	29	1	606	1	FCN3	1	27699711	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1008462	27699711	221550910	12	6209										
GMEB1	10691	broad.mit.edu	37	chr1	29040947	29040947	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccaagagcagctcaccagacAcagtgaccatccacccttca	6	17	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:29040947A>C	uc001bra.2	+	10	1522	c.1384A>C	c.(1384-1386)ACA>CCA	p.T462P	GMEB1_uc001bqz.2_Missense_Mutation_p.T452P|GMEB1_uc001brb.2_Missense_Mutation_p.T452P	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CTCACCAGACACAGTGACCAT	0.582													0	0	0	0.003954	0	26	83										C	29040947	A	C	29040947	3	2	22	1	0	0	0	0	1	0	0	0	6487	159	6	5	1418	5	GMEB1	1	29040947	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	1341236	29040947	220209674	13	6210										
S100PBP	64766	broad.mit.edu	37	chr1	33321593	33321593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgggttgacaggaacatgcGaagccaccatcggttccagc	13	11	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:33321593G>A	uc001bvz.2	+	7	1458	c.1181G>A	c.(1180-1182)CGA>CAA	p.R394Q	S100PBP_uc001bwc.2_Missense_Mutation_p.R394Q|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	394						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGAACATGCGAAGCCACCAT	0.512													0	0	0	0.003954	0	25	60										A	33321593	G	A	33321593	3	1	22	1	0	0	0	0	1	0	0	0	13791	1058	37	1	1208	1	S100PBP	1	33321593	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4280646	33321593	215929028	14	6211										
DLGAP3	58512	broad.mit.edu	37	chr1	35365869	35365869	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taacccccccagtcatcttgCggcacctgcaggaacagggg	11	15	2	0	rs139408471		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:35365869C>T	uc001byc.2	-	2	1113	c.1113G>A	c.(1111-1113)CCG>CCA	p.P371P		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	371					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				AGTCATCTTGCGGCACCTGCA	0.612													0	0	0	0.006122	0	18	187										T	35365869	C	T	35365869	2	4	22	1	0	0	0	0	0	0	0	1	4561	755	27	2		2	DLGAP3	1	35365869	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2044276	35365869	213884752	15	6212										
RSPO1	284654	broad.mit.edu	37	chr1	38079496	38079496	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccgctcctcggagcccctccGgaaaccacagagctgctgct	10	18	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:38079496G>A	uc001cbl.1	-	7	1293	c.505C>T	c.(505-507)CGG>TGG	p.R169W	RSPO1_uc001cbm.1_Missense_Mutation_p.R169W|RSPO1_uc009vvf.1_Missense_Mutation_p.R142W|RSPO1_uc009vvg.1_Intron	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	169	TSP type-1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAGCCCCTCCGGAAACCACAG	0.627													0	0	0	0.00308	0	8	117										A	38079496	G	A	38079496	3	1	22	1	0	0	0	0	1	0	0	0	13709	1115	39	2	294	2	RSPO1	1	38079496	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2713627	38079496	211171125	16	6213										
LEPRE1	64175	broad.mit.edu	37	chr1	43224586	43224586	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaagtcttcaaagggcttctCtcgacttgggtgggaagcaa	13	8	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:43224586C>G	uc001chv.2	-	4	990	c.877G>C	c.(877-879)GAG>CAG	p.E293Q	LEPRE1_uc001chw.2_Missense_Mutation_p.E293Q|LEPRE1_uc001chx.3_Missense_Mutation_p.E293Q	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	293					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AAGGGCTTCTCTCGACTTGGG	0.443													0	0	0	0.00361	0	51	63										G	43224586	C	G	43224586	3	3	22	1	0	0	0	0	1	0	0	0	8729	922	32	1	1400	1	LEPRE1	1	43224586	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5145090	43224586	206026035	17	6214										
TIE1	7075	broad.mit.edu	37	chr1	43778138	43778138	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggagcggcgggagaacgtctCatccccccaggcccgcactg	14	16	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:43778138C>T	uc001ciu.2	+	12	1872	c.1793C>T	c.(1792-1794)TCA>TTA	p.S598L	TIE1_uc010okd.1_Missense_Mutation_p.S598L|TIE1_uc010oke.1_Missense_Mutation_p.S553L|TIE1_uc009vwq.2_Missense_Mutation_p.S554L|TIE1_uc010okf.1_Missense_Mutation_p.S243L|TIE1_uc010okg.1_Missense_Mutation_p.S243L	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	598	Fibronectin type-III 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GAGAACGTCTCATCCCCCCAG	0.706													0	0	0	0.001168	0	5	42										T	43778138	C	T	43778138	3	4	22	1	0	0	0	0	1	0	0	0	15890	838	29	1	1839	1	TIE1	1	43778138	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	553552	43778138	205472483	18	6215										
SLC6A9	6536	broad.mit.edu	37	chr1	44482736	44482736	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gacctgttctggggaagaggGggccacaggtccatgagccg	17	10	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:44482736G>T	uc001cll.2	-	1	262	c.70C>A	c.(70-72)CCC>ACC	p.P24T	SLC6A9_uc009vxe.2_5'Flank|SLC6A9_uc010okm.1_Intron|SLC6A9_uc001clm.2_Missense_Mutation_p.P24T|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.P24T|SLC6A9_uc001cln.2_Intron|SLC6A9_uc010oko.1_Intron|SLC6A9_uc010okp.1_Intron	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	24	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GGGGAAGAGGGGGCCACAGGT	0.677													1	0	7.07596e-05	0.006122	7.30378e-05	14	59										T	44482736	G	T	44482736	3	4	22	1	0	0	0	0	1	0	0	0	14691	1232	43	4	2106	4	SLC6A9	1	44482736	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	704598	44482736	204767885	19	6216										
PRDX1	5052	broad.mit.edu	37	chr1	45981460	45981460	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgaagtcaagagggtaaaaGaagaacacaacatattttcc	9	6	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:45981460G>C	uc001cnz.2	-	2	158	c.126C>G	c.(124-126)TTC>TTG	p.F42L	PRDX1_uc001coa.2_Missense_Mutation_p.F42L|PRDX1_uc001cob.2_Missense_Mutation_p.F42L|PRDX1_uc001coc.2_Missense_Mutation_p.F42L	NM_181697	NP_859048	Q06830	PRDX1_HUMAN	peroxiredoxin 1	42	Thioredoxin.				cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity				0	Acute lymphoblastic leukemia(166;0.155)					GAGGGTAAAAGAAGAACACAA	0.408													0	0	0	0.00361	0	67	57										C	45981460	G	C	45981460	3	2	22	1	0	0	0	0	1	0	0	0	12464	933	33	1	489	1	PRDX1	1	45981460	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1498724	45981460	203269161	20	6217										
CCDC17	149483	broad.mit.edu	37	chr1	46086690	46086690	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cttggtcaaatagtccaagtGagacccaagcctttggctgt	10	10	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:46086690G>A	uc010olt.1	-	11	1632	c.1484C>T	c.(1483-1485)TCA>TTA	p.S495L	CCDC17_uc009vxy.2_Missense_Mutation_p.S463L|CCDC17_uc010ols.1_Missense_Mutation_p.S486L|CCDC17_uc001com.3_Missense_Mutation_p.S316L|CCDC17_uc001con.3_RNA|CCDC17_uc009vxz.2_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	495										ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TAGTCCAAGTGAGACCCAAGC	0.592													0	0	0	0.005443	0	26	26										A	46086690	G	A	46086690	3	1	22	1	0	0	0	0	1	0	0	0	2793	1294	45	1	396	1	CCDC17	1	46086690	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	105230	46086690	203163931	21	6218										
LRRC41	10489	broad.mit.edu	37	chr1	46744710	46744710	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccacggccccagcgctccaGccgcttggcgaactccagaa	10	18	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:46744710G>T	uc001cpn.2	-	10	2310	c.2266C>A	c.(2266-2268)CTG>ATG	p.L756M	LRRC41_uc010omb.1_3'UTR	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	756										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CAGCGCTCCAGCCGCTTGGCG	0.582													1	0	1.5842e-08	0.001855	1.69292e-08	11	64										T	46744710	G	T	46744710	3	4	22	1	0	0	0	0	1	0	0	0	8999	962	34	4	176	4	LRRC41	1	46744710	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	658020	46744710	202505911	22	6219										
ZYG11B	79699	broad.mit.edu	37	chr1	53287142	53287142	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgcagcatgctgattgaagaAggaggattgcagcatttata	12	5	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:53287142A>C	uc001cuj.2	+	14	2271	c.2076A>C	c.(2074-2076)GAA>GAC	p.E692D	ZYG11B_uc010onj.1_Missense_Mutation_p.E613D|ZYG11B_uc009vzh.2_Missense_Mutation_p.E114D	NM_024646	NP_078922	Q9C0D3	ZY11B_HUMAN	zyg-11 homolog B	692							protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TGATTGAAGAAGGAGGATTGC	0.358													0	0	0	0.009096	0	4	55										C	53287142	A	C	53287142	3	2	22	1	0	0	0	0	1	0	0	0	18250	69	3	5	2130	5	ZYG11B	1	53287142	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	6542432	53287142	195963479	23	6220										
PODN	127435	broad.mit.edu	37	chr1	53544320	53544320	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcgtgcccagtggcctgcctCgccgcgtgcgcaccctcatg	13	18	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:53544320C>A	uc001cuv.2	+	8	1289	c.1282C>A	c.(1282-1284)CGC>AGC	p.R428S	PODN_uc001cuw.2_Missense_Mutation_p.R409S|PODN_uc010onr.1_Missense_Mutation_p.R409S|PODN_uc010ons.1_Missense_Mutation_p.R286S	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	380	LRR 12.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						TGGCCTGCCTCGCCGCGTGCG	0.632													1	0	1.76056e-25	0.011902	2.00733e-25	44	148										A	53544320	C	A	53544320	3	1	22	1	0	0	0	0	1	0	0	0	12178	884	31	3	1312	3	PODN	1	53544320	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	257178	53544320	195706301	24	6221										
USP1	7398	broad.mit.edu	37	chr1	62916526	62916526	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caaagcttaaaggagtatgaGgggaagtggttgctttttga	14	3	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:62916526G>C	uc001daj.1	+	9	2560	c.2232G>C	c.(2230-2232)GAG>GAC	p.E744D	USP1_uc001dak.1_Missense_Mutation_p.E744D|USP1_uc001dal.1_Missense_Mutation_p.E744D	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	744					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		AGGAGTATGAGGGGAAGTGGT	0.373													0	0	0	0.010729	0	12	56										C	62916526	G	C	62916526	3	2	22	1	0	0	0	0	1	0	0	0	17037	991	35	4	2262	4	USP1	1	62916526	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	9372206	62916526	186334095	25	6222										
SGIP1	84251	broad.mit.edu	37	chr1	67155919	67155919	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttcttccagccctcctccaaTagcacccttagcgcgggctg	8	17	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:67155919T>C	uc001dcr.2	+	17	1707	c.1490T>C	c.(1489-1491)ATA>ACA	p.I497T	SGIP1_uc010opd.1_Missense_Mutation_p.I97T|SGIP1_uc001dcs.2_Missense_Mutation_p.I97T|SGIP1_uc001dct.2_Missense_Mutation_p.I97T|SGIP1_uc009wat.2_Missense_Mutation_p.I291T	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	497	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						CCTCCTCCAATAGCACCCTTA	0.458													0	0	0	0.007413	0	17	235										C	67155919	T	C	67155919	3	2	22	1	0	0	0	0	1	0	0	0	14206	1406	49	5	1556	5	SGIP1	1	67155919	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	4239393	67155919	182094702	26	6223										
ABCD3	5825	broad.mit.edu	37	chr1	94943841	94943841	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttagacatagttttgtatatCtttaagttaacgagtgcaat	7	4	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:94943841C>G	uc001dqn.3	+	8	756	c.654C>G	c.(652-654)ATC>ATG	p.I218M	ABCD3_uc001dqm.3_Missense_Mutation_p.I218M|ABCD3_uc010oto.1_Missense_Mutation_p.I242M|ABCD3_uc010otp.1_Missense_Mutation_p.I145M|ABCD3_uc009wdr.2_Missense_Mutation_p.I218M	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	218	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTTTGTATATCTTTAAGTTAA	0.259													0	0	0	0.000602	0	4	27										G	94943841	C	G	94943841	3	3	22	1	0	0	0	0	1	0	0	0	62	903	32	1	684	1	ABCD3	1	94943841	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	27787922	94943841	154306780	27	6224										
KCNA2	3737	broad.mit.edu	37	chr1	111146504	111146504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caacttgaaaatcctaaagaCtcttaccaaccggatgacac	5	12	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:111146504C>T	uc001dzu.2	-	2	1397	c.901G>A	c.(901-903)GTC>ATC	p.V301I	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.V301I	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	301	Helical; Voltage-sensor; Name=Segment S4; (Potential).					juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ATCCTAAAGACTCTTACCAAC	0.527													0	0	0	0.004289	0	37	162										T	111146504	C	T	111146504	3	4	22	1	0	0	0	0	1	0	0	0	8003	565	20	2	602	2	KCNA2	1	111146504	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	16202663	111146504	138104117	28	6225										
TSPAN2	10100	broad.mit.edu	37	chr1	115600206	115600206	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtaggttggacctgttcggaGctttcttttccacagcactg	11	10	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:115600206G>C	uc001eft.2	-	6	530	c.468C>G	c.(466-468)AGC>AGG	p.S156R		NM_005725	NP_005716	O60636	TSN2_HUMAN	tetraspan 2	156	Extracellular (Potential).					integral to membrane					0	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		CCTGTTCGGAGCTTTCTTTTC	0.493													0	0	0	0.007291	0	23	269										C	115600206	G	C	115600206	3	2	22	1	0	0	0	0	1	0	0	0	16641	962	34	4	209	4	TSPAN2	1	115600206	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4453702	115600206	133650415	29	6226										
ITGA10	8515	broad.mit.edu	37	chr1	145534181	145534181	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cttcctgatctgaaccaagaTggttttgctgatgtggctgt	11	8	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:145534181T>C	uc001eoa.2	+	14	1762	c.1686T>C	c.(1684-1686)GAT>GAC	p.D562D	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.D431D|ITGA10_uc009wiw.2_Silent_p.D419D|ITGA10_uc010oyw.1_Silent_p.D507D	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	562	Potential.|Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGAACCAAGATGGTTTTGCTG	0.582													0	0	0	0.005524	0	37	489										C	145534181	T	C	145534181	2	2	22	1	0	0	0	0	0	0	0	1	7873	1461	51	5		5	ITGA10	1	145534181	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	29933975	145534181	103716440	30	6227										
C1orf54	79630	broad.mit.edu	37	chr1	150246527	150246527	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaagaaagactgggagaggaTgaatattatcaggtggtcta	14	3	2	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:150246527T>A	uc001eud.2	+	2	122	c.84T>A	c.(82-84)GAT>GAA	p.D28E	C1orf54_uc001euc.2_Missense_Mutation_p.D28E|C1orf54_uc001eue.2_Missense_Mutation_p.D28E|C1orf54_uc001euf.2_Missense_Mutation_p.D28E|C1orf54_uc001eug.2_Missense_Mutation_p.D28E	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	28						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGGAGAGGATGAATATTATC	0.448													0	0	0	0.012213	0	30	325										A	150246527	T	A	150246527	3	1	22	1	0	0	0	0	1	0	0	0	2046	1461	51	5	90	5	C1orf54	1	150246527	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	4712346	150246527	99004094	31	6228										
SETDB1	9869	broad.mit.edu	37	chr1	150915383	150915383	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaaggaaagagtctactgtcGgggaaccatattgcctatga	11	7	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:150915383G>A	uc001evu.2	+	7	919	c.729G>A	c.(727-729)TCG>TCA	p.S243S	SETDB1_uc009wmf.2_Silent_p.S243S|SETDB1_uc001evv.2_Silent_p.S243S|SETDB1_uc001evw.3_Silent_p.S243S|SETDB1_uc009wmg.1_Silent_p.S243S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTCTACTGTCGGGGAACCATA	0.453													0	0	0	0.008871	0	17	260										A	150915383	G	A	150915383	2	1	22	1	0	0	0	0	0	0	0	1	14138	1103	39	2		2	SETDB1	1	150915383	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	668856	150915383	98335238	32	6229										
FLG	2312	broad.mit.edu	37	chr1	152279926	152279926	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagatctatctaccaattgcTcgtagtgggatccctgcctt	8	12	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:152279926T>G	uc001ezu.1	-	3	7472	c.7436A>C	c.(7435-7437)GAG>GCG	p.E2479A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2479	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TACCAATTGCTCGTAGTGGGA	0.572									Ichthyosis				0	0	0	0.00361	0	74	870										G	152279926	T	G	152279926	3	3	22	1	0	0	0	0	1	0	0	0	5922	1551	54	5	4753	5	FLG	1	152279926	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	1364543	152279926	96970695	33	6230										
DCST1	149095	broad.mit.edu	37	chr1	155018907	155018907	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtggcttggactgggctctCtactccatcttcgacaccat	9	13	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155018907C>T	uc001fgn.1	+	13	1536	c.1440C>T	c.(1438-1440)CTC>CTT	p.L480L	DCST1_uc010per.1_Silent_p.L505L|DCST1_uc010pes.1_Silent_p.L455L|uc001fgo.2_Intron	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	480	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			ACTGGGCTCTCTACTCCATCT	0.612													0	0	0	0.004007	0	16	186										T	155018907	C	T	155018907	2	4	22	1	0	0	0	0	0	0	0	1	4302	900	32	1		1	DCST1	1	155018907	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2738981	155018907	94231714	34	6231										
THBS3	7059	broad.mit.edu	37	chr1	155172605	155172605	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggctctgacctccctcacctCattgatgtcactgcagtggg	10	14	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155172605C>T	uc001fix.2	-	8	978	c.955G>A	c.(955-957)GAG>AAG	p.E319K	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Missense_Mutation_p.E310K|THBS3_uc001fiz.2_Missense_Mutation_p.E319K|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Missense_Mutation_p.E199K|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	319	EGF-like 2; calcium-binding (Potential).				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCCCTCACCTCATTGATGTCA	0.607													0	0	0	0.00361	0	42	143										T	155172605	C	T	155172605	3	4	22	1	0	0	0	0	1	0	0	0	15852	835	29	1	1979	1	THBS3	1	155172605	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	153698	155172605	94078016	35	6232										
DAP3	7818	broad.mit.edu	37	chr1	155698905	155698905	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggagtcctctgggagaagtgGttgaacaggtataagaaaaa	14	4	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155698905G>A	uc001flq.2	+	8	845	c.676G>A	c.(676-678)GTT>ATT	p.V226I	DAP3_uc001flr.2_Missense_Mutation_p.V226I|DAP3_uc001fls.2_Missense_Mutation_p.V226I|DAP3_uc010pgl.1_Missense_Mutation_p.V185I|DAP3_uc001flt.2_Missense_Mutation_p.V192I|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Missense_Mutation_p.V192I	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	226					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GGGAGAAGTGGTTGAACAGGT	0.398													0	0	0	0.008291	0	10	152										A	155698905	G	A	155698905	3	1	22	1	0	0	0	0	1	0	0	0	4234	1261	44	2	702	2	DAP3	1	155698905	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	526300	155698905	93551716	36	6233										
RXFP4	339403	broad.mit.edu	37	chr1	155912334	155912334	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgaagtttgacctggtgccCtggaacagtactttctatac	10	9	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:155912334C>T	uc010pgs.1	+	1	855	c.834C>T	c.(832-834)CCC>CCT	p.P278P		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	278	Extracellular (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					ACCTGGTGCCCTGGAACAGTA	0.537													0	0	0	0.00361	0	172	204										T	155912334	C	T	155912334	2	4	22	1	0	0	0	0	0	0	0	1	13762	668	24	2		2	RXFP4	1	155912334	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	213429	155912334	93338287	37	6234										
ARHGAP30	257106	broad.mit.edu	37	chr1	161021373	161021373	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcgtggtgtgcctggttcaGagtttgtgccacccagtgct	13	11	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:161021373G>C	uc001fxl.2	-	10	1497	c.1151C>G	c.(1150-1152)TCT>TGT	p.S384C	ARHGAP30_uc001fxk.2_Missense_Mutation_p.S384C|ARHGAP30_uc001fxm.2_Missense_Mutation_p.S230C|ARHGAP30_uc009wtx.2_Missense_Mutation_p.S57C|ARHGAP30_uc001fxn.1_Missense_Mutation_p.S230C	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	384					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCCTGGTTCAGAGTTTGTGCC	0.607													0	0	0	0.00361	0	47	257										C	161021373	G	C	161021373	3	2	22	1	0	0	0	0	1	0	0	0	879	942	33	1	2166	1	ARHGAP30	1	161021373	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5109039	161021373	88229248	38	6235										
USP21	27005	broad.mit.edu	37	chr1	161130596	161130596	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tacgacctctgcctccccggCcaggtctgcctgatgaacgg	11	16	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:161130596C>T	uc010pke.1	+	3	543	c.166C>T	c.(166-168)CCA>TCA	p.P56S	USP21_uc010pkc.1_Missense_Mutation_p.P56S|USP21_uc010pkd.1_Missense_Mutation_p.P56S|USP21_uc010pkf.1_Missense_Mutation_p.P56S	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	56					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCCTCCCCGGCCAGGTCTGCC	0.642													0	0	0	0.008291	0	11	242										T	161130596	C	T	161130596	3	4	22	1	0	0	0	0	1	0	0	0	17050	739	26	2	168	2	USP21	1	161130596	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	109223	161130596	88120025	39	6236										
OLFML2B	25903	broad.mit.edu	37	chr1	161954646	161954646	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	accagggtgttgccgtagtaAtagttggttacgtaaatccg	12	7	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:161954646A>G	uc001gbu.2	-	7	2023	c.1599T>C	c.(1597-1599)TAT>TAC	p.Y533Y	OLFML2B_uc001gbt.2_Silent_p.Y16Y|OLFML2B_uc010pkq.1_Silent_p.Y534Y	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	533	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TGCCGTAGTAATAGTTGGTTA	0.537													0	0	0	0.00361	0	76	382										G	161954646	A	G	161954646	2	3	22	1	0	0	0	0	0	0	0	1	10858	108	4	5		5	OLFML2B	1	161954646	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	824050	161954646	87295975	40	6237										
ILDR2	387597	broad.mit.edu	37	chr1	166927059	166927059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aatctcccagggtgacagtcGagccctgttttgaagctact	10	11	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:166927059G>A	uc001gdx.1	-	2	382	c.326C>T	c.(325-327)TCG>TTG	p.S109L		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	109	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						GGTGACAGTCGAGCCCTGTTT	0.493													0	0	0	0.00361	0	46	174										A	166927059	G	A	166927059	3	1	22	1	0	0	0	0	1	0	0	0	7710	1059	37	1	1629	1	ILDR2	1	166927059	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4972413	166927059	82323562	41	6238										
KLHL20	27252	broad.mit.edu	37	chr1	173754326	173754326	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atggcgggatgaattaccgtCggctagggggtggcgtagga	19	6	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:173754326C>T	uc001gjc.2	+	12	1950	c.1771C>T	c.(1771-1773)CGG>TGG	p.R591W	KLHL20_uc010pmr.1_Missense_Mutation_p.R402W|KLHL20_uc009wwf.2_Missense_Mutation_p.R573W	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	591	Kelch 6.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GAATTACCGTCGGCTAGGGGG	0.363													0	0	0	0.004878	0	32	44										T	173754326	C	T	173754326	3	4	22	1	0	0	0	0	1	0	0	0	8375	875	31	1	1813	1	KLHL20	1	173754326	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6827267	173754326	75496295	42	6239										
TNR	7143	broad.mit.edu	37	chr1	175336348	175336348	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagtcctcctactcaccagtCctggcattcatggtggctgg	10	14	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:175336348C>G	uc001gkp.1	-	8	2130	c.2049G>C	c.(2047-2049)AGG>AGC	p.R683S	TNR_uc009wwu.1_Missense_Mutation_p.R683S	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	683	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACTCACCAGTCCTGGCATTCA	0.493													0	0	0	0.010818	0	27	85										G	175336348	C	G	175336348	3	3	22	1	0	0	0	0	1	0	0	0	16335	854	30	1	2083	1	TNR	1	175336348	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1582022	175336348	73914273	43	6240										
HMCN1	83872	broad.mit.edu	37	chr1	186094817	186094817	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcttccatgcgtagctgatgGaatccccacaccagcaatta	7	13	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:186094817G>C	uc001grq.1	+	82	12810	c.12581G>C	c.(12580-12582)GGA>GCA	p.G4194A	HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4194	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTAGCTGATGGAATCCCCACA	0.388													0	0	0	0.00632	0	26	70										C	186094817	G	C	186094817	3	2	22	1	0	0	0	0	1	0	0	0	7220	1174	41	1	12907	1	HMCN1	1	186094817	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10758469	186094817	63155804	44	6241										
HMCN1	83872	broad.mit.edu	37	chr1	186114897	186114897	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gttcacagtggatggaagttGgggaagctggcatagttgga	17	4	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:186114897G>A	uc001grq.1	+	93	14679	c.14450G>A	c.(14449-14451)TGG>TAG	p.W4817*	HMCN1_uc001grs.1_Nonsense_Mutation_p.W386*	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4817	TSP type-1 6.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATGGAAGTTGGGGAAGCTGG	0.498													0	0	0	0.00361	0	60	75										A	186114897	G	A	186114897	4	1	22	1	0	0	0	0	0	1	0	0	7220	1357	47	2	14820	2	HMCN1	1	186114897	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	20080	186114897	63135724	45	6242										
ASPM	259266	broad.mit.edu	37	chr1	197073065	197073065	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ataattgctttatacattttCagataatactgccgagcctt	5	8	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:197073065C>T	uc001gtu.2	-	18	5573	c.5316G>A	c.(5314-5316)CTG>CTA	p.L1772L	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1772	IQ 7.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TATACATTTTCAGATAATACT	0.358													0	0	0	0.001855	0	14	90										T	197073065	C	T	197073065	2	4	22	1	0	0	0	0	0	0	0	1	1056	813	29	1		1	ASPM	1	197073065	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	10958168	197073065	52177556	46	6243										
LGTN	1939	broad.mit.edu	37	chr1	206782760	206782760	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	accagtttctcgagcaccagAggccatgttgtaaaggttgg	12	9	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:206782760A>C	uc001heh.2	-	3	509	c.300T>G	c.(298-300)CCT>CCG	p.P100P	LGTN_uc009xbw.2_Silent_p.P100P|LGTN_uc010prw.1_Silent_p.P100P	NM_006893	NP_008824	P41214	EIF2D_HUMAN	ligatin	100	PUA.				intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CGAGCACCAGAGGCCATGTTG	0.438													0	0	0	0.001368	0	12	105										C	206782760	A	C	206782760	2	2	22	1	0	0	0	0	0	0	0	1	8760	291	11	5		5	LGTN	1	206782760	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	9709695	206782760	42467861	47	6244										
NENF	29937	broad.mit.edu	37	chr1	212617721	212617721	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccctacaatgccttgacgggGaaggactccactagaggggt	13	11	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:212617721G>A	uc001hjd.2	+	3	336	c.279G>A	c.(277-279)GGG>GGA	p.G93G	NENF_uc010ptf.1_RNA	NM_013349	NP_037481	Q9UMX5	NENF_HUMAN	neuron derived neurotrophic factor precursor	93	Cytochrome b5 heme-binding.					extracellular space	heme binding				0				all cancers(67;0.00967)|OV - Ovarian serous cystadenocarcinoma(81;0.0108)|GBM - Glioblastoma multiforme(131;0.0325)|Epithelial(68;0.132)		CCTTGACGGGGAAGGACTCCA	0.512													0	0	0	0.001368	0	12	93										A	212617721	G	A	212617721	2	1	22	1	0	0	0	0	0	0	0	1	10335	1161	41	1		1	NENF	1	212617721	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5834961	212617721	36632900	48	6245										
KCTD3	51133	broad.mit.edu	37	chr1	215792292	215792292	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttacagtgagggaatgtgagGgatccagtaggatgggctca	16	5	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:215792292G>A	uc001hks.2	+	16	1921	c.1627G>A	c.(1627-1629)GGA>AGA	p.G543R	KCTD3_uc001hkt.2_Missense_Mutation_p.G543R|KCTD3_uc010pub.1_Missense_Mutation_p.G441R|KCTD3_uc009xdn.2_Missense_Mutation_p.G267R	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	543	WD 5.					voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		GGAATGTGAGGGATCCAGTAG	0.453													0	0	0	0.006214	0	8	107										A	215792292	G	A	215792292	3	1	22	1	0	0	0	0	1	0	0	0	8110	1233	43	2	1689	2	KCTD3	1	215792292	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3174571	215792292	33458329	49	6246										
BPNT1	10380	broad.mit.edu	37	chr1	220233036	220233036	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaacagactaacctcccacaGcatgtaaaataacttctgga	5	11	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:220233036G>T	uc001hma.2	-	8	942	c.770C>A	c.(769-771)GCT>GAT	p.A257D	BPNT1_uc010pug.1_Missense_Mutation_p.A202D|BPNT1_uc010puh.1_Missense_Mutation_p.A221D|BPNT1_uc001hmb.3_Missense_Mutation_p.A272D	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	257					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		ACCTCCCACAGCATGTAAAAT	0.338													1	0	1.5842e-08	0.001855	1.69292e-08	14	136										T	220233036	G	T	220233036	3	4	22	1	0	0	0	0	1	0	0	0	1494	971	34	4	164	4	BPNT1	1	220233036	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4440744	220233036	29017585	50	6247										
AIDA	64853	broad.mit.edu	37	chr1	222867175	222867175	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccagtttaaattcttcttgaGactgtgtggactaaatttaa	7	6	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:222867175G>C	uc001hnn.2	-	4	450	c.245C>G	c.(244-246)TCT>TGT	p.S82C	AIDA_uc001hno.2_RNA|AIDA_uc010pus.1_Missense_Mutation_p.S58C	NM_022831	NP_073742	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	82					dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity						0						TTCTTCTTGAGACTGTGTGGA	0.313													0	0	0	0.010729	0	11	26										C	222867175	G	C	222867175	3	2	22	1	0	0	0	0	1	0	0	0	423	942	33	1	703	1	AIDA	1	222867175	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2634139	222867175	26383446	51	6248										
LYST	1130	broad.mit.edu	37	chr1	235884050	235884050	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggatactgcatgagatcattGaaggatcggccagcatgttt	12	7	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr1:235884050G>A	uc001hxj.2	-	40	9646	c.9471C>T	c.(9469-9471)TTC>TTT	p.F3157F	LYST_uc001hxi.2_Silent_p.F381F	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3157	BEACH.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGAGATCATTGAAGGATCGGC	0.363									Chediak-Higashi_syndrome				0	0	0	0.005524	0	38	112										A	235884050	G	A	235884050	2	1	22	1	0	0	0	0	0	0	0	1	9128	1281	45	1		1	LYST	1	235884050	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	13016875	235884050	13366571	52	6249										
FAM110C	642273	broad.mit.edu	37	chr2	45650	45650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gctcacgctgcgcaccttgaGggtcacacagtccgaccccg	11	17	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:45650G>A	uc010yim.1	-	1	736	c.736C>T	c.(736-738)CTC>TTC	p.L246F		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	hypothetical protein LOC642273	246						microtubule|microtubule organizing center|spindle pole					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CGCACCTTGAGGGTCACACAG	0.687													0	0	0	0.004672	0	3	31										A	45650	G	A	45650	3	1	22	1	0	0	0	0	1	0	0	0	5398	1000	35	2	237	2	FAM110C	2	45650	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08		45650	243153723	53	6250										
NBAS	51594	broad.mit.edu	37	chr2	15448382	15448382	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccctgaaacatggggccaaTcgggcatagatctggaggct	13	10	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:15448382T>A	uc002rcc.1	-	40	4781	c.4755A>T	c.(4753-4755)CGA>CGT	p.R1585R	NBAS_uc010exl.1_Silent_p.R657R|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1585										ovary(2)|liver(1)|skin(1)	4						ATGGGGCCAATCGGGCATAGA	0.463													0	0	0	0.001984	0	7	89										A	15448382	T	A	15448382	2	1	22	1	0	0	0	0	0	0	0	1	10186	1422	50	5		5	NBAS	2	15448382	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	15402732	15448382	227750991	54	6251										
SPAST	6683	broad.mit.edu	37	chr2	32340842	32340842	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actcgtaagaaaaaagacttGaagaattttaggaatgtgga	10	3	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:32340842G>A	uc002roc.2	+	6	1163	c.942G>A	c.(940-942)TTG>TTA	p.L314L	SPAST_uc002rod.2_Silent_p.L282L	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	314	Required for interaction with microtubules and microtubule severing.|Sufficient for microtubule severing.|Sufficient for interaction with microtubules.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AAAAAGACTTGAAGAATTTTA	0.303													0	0	0	0.002836	0	30	48										A	32340842	G	A	32340842	2	1	22	1	0	0	0	0	0	0	0	1	14996	1281	45	1		1	SPAST	2	32340842	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16892460	32340842	210858531	55	6252										
THADA	63892	broad.mit.edu	37	chr2	43808919	43808919	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaaaatactcagcaatccacAcatattttgccatatgggag	6	9	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:43808919A>G	uc002rsw.3	-	8	1034	c.682T>C	c.(682-684)TGT>CGT	p.C228R	THADA_uc002rsx.3_Missense_Mutation_p.C228R|THADA_uc002rsy.3_RNA|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Missense_Mutation_p.C228R|THADA_uc002rtc.3_Missense_Mutation_p.C228R|THADA_uc002rtd.2_Missense_Mutation_p.C228R	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	228							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGCAATCCACACATATTTTGC	0.333													0	0	0	0.004482	0	8	72										G	43808919	A	G	43808919	3	3	22	1	0	0	0	0	1	0	0	0	15837	159	6	5	5303	5	THADA	2	43808919	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	11468077	43808919	199390454	56	6253										
MSH6	2956	broad.mit.edu	37	chr2	48027760	48027760	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggatcatggaagaagttgctGatggttttaagtctaaaatc	11	4	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:48027760G>T	uc002rwd.3	+	4	2790	c.2638G>T	c.(2638-2640)GAT>TAT	p.D880Y	MSH6_uc002rwc.2_Missense_Mutation_p.D880Y|MSH6_uc010fbj.2_Missense_Mutation_p.D578Y|MSH6_uc010yoi.1_Missense_Mutation_p.D750Y|MSH6_uc010yoj.1_Missense_Mutation_p.D578Y	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	880					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGAAGTTGCTGATGGTTTTAA	0.363			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				1	0	1.96895e-08	0.00278	2.09585e-08	23	120										T	48027760	G	T	48027760	3	4	22	1	0	0	0	0	1	0	0	0	9874	1290	45	3	2652	3	MSH6	2	48027760	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4218841	48027760	195171613	57	6254										
NRXN1	9378	broad.mit.edu	37	chr2	51254845	51254845	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcaggacctgcgaggagttGaccctcacgtcacgaatcca	12	13	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:51254845G>A	uc010fbq.2	-	2	2044	c.567C>T	c.(565-567)GTC>GTT	p.V189V	NRXN1_uc002rxe.3_Silent_p.V189V|NRXN1_uc002rxd.1_Silent_p.V189V	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCGAGGAGTTGACCCTCACGT	0.721													0	0	0	0.003163	0	13	11										A	51254845	G	A	51254845	2	1	22	1	0	0	0	0	0	0	0	1	10665	1277	45	1		1	NRXN1	2	51254845	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3227085	51254845	191944528	58	6255										
C2orf63	130162	broad.mit.edu	37	chr2	55407749	55407749	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttgtgcaggccacattcactGtagacaatctgagctaaagc	9	10	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:55407749G>T	uc002ryi.2	-	11	1627	c.1281C>A	c.(1279-1281)TAC>TAA	p.Y427*	C2orf63_uc002ryh.2_5'UTR|C2orf63_uc002ryj.2_Nonsense_Mutation_p.Y305*	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	427							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			CACATTCACTGTAGACAATCT	0.448													1	0	7.88023e-25	0.00361	8.94735e-25	49	76										T	55407749	G	T	55407749	4	4	22	1	0	0	0	0	0	1	0	0	2182	1372	48	4	491	4	C2orf63	2	55407749	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4152904	55407749	187791624	59	6256										
CCDC104	112942	broad.mit.edu	37	chr2	55764680	55764680	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgaagctgcaataatgaataAttcccaaggggatggtgaac	11	6	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:55764680A>G	uc002ryy.2	+	7	797	c.599A>G	c.(598-600)AAT>AGT	p.N200S	CCDC104_uc002ryx.2_Missense_Mutation_p.N225S	NM_080667	NP_542398	Q96G28	CC104_HUMAN	coiled-coil domain containing 104	200										ovary(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ATAATGAATAATTCCCAAGGG	0.373													0	0	0	0.001984	0	6	101										G	55764680	A	G	55764680	3	3	22	1	0	0	0	0	1	0	0	0	2739	101	4	5	625	5	CCDC104	2	55764680	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	356931	55764680	187434693	60	6257										
USP34	9736	broad.mit.edu	37	chr2	61622358	61622358	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctaatatgttactttcttgaGttgatatatcctaattaaaa	4	5	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:61622358G>A	uc002sbe.2	-	4	585	c.563C>T	c.(562-564)ACT>ATT	p.T188I		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	188					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			ACTTTCTTGAGTTGATATATC	0.229													0	0	0	0.006214	0	10	11										A	61622358	G	A	61622358	3	1	22	1	0	0	0	0	1	0	0	0	17062	1029	36	2	10385	2	USP34	2	61622358	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5857678	61622358	181577015	61	6258										
ETAA1	54465	broad.mit.edu	37	chr2	67630594	67630594	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccaatcaaaggaaacaccaaGatatctgtggcaaataatca	6	9	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:67630594G>C	uc002sdz.1	+	5	919	c.780G>C	c.(778-780)AAG>AAC	p.K260N		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	260						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						GAAACACCAAGATATCTGTGG	0.313													0	0	0	0.00245	0	15	87										C	67630594	G	C	67630594	3	2	22	1	0	0	0	0	1	0	0	0	5267	933	33	1	798	1	ETAA1	2	67630594	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6008236	67630594	175568779	62	6259										
ARHGAP25	9938	broad.mit.edu	37	chr2	69002357	69002357	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgttcctctctatagctcgGtcaaggagtgtgatgactgg	12	9	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:69002357G>T	uc002seu.2	+	2	430	c.66G>T	c.(64-66)CGG>CGT	p.R22R	ARHGAP25_uc010yqk.1_5'UTR|ARHGAP25_uc010fdg.2_Silent_p.R22R|ARHGAP25_uc010yql.1_Silent_p.R22R|ARHGAP25_uc002sev.2_Silent_p.R15R|ARHGAP25_uc002sew.2_Silent_p.R15R|ARHGAP25_uc002sex.2_Silent_p.R15R|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	22					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CTATAGCTCGGTCAAGGAGTG	0.612													1	0	6.27289e-28	0.00361	7.1822e-28	45	599										T	69002357	G	T	69002357	2	4	22	1	0	0	0	0	0	0	0	1	874	1248	44	4		4	ARHGAP25	2	69002357	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1371763	69002357	174197016	63	6260										
LOXL3	84695	broad.mit.edu	37	chr2	74779494	74779494	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgggtccagcctgtggcctCtgtgaagcccagctcccggc	14	15	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:74779494C>G	uc002smp.1	-	2	340	c.268G>C	c.(268-270)GAG>CAG	p.E90Q	LOXL3_uc002smo.1_5'Flank|LOXL3_uc010ffm.1_Missense_Mutation_p.E90Q|LOXL3_uc002smq.1_Missense_Mutation_p.E90Q|LOXL3_uc010ffn.1_Missense_Mutation_p.E90Q|DOK1_uc002smr.2_Intron|DOK1_uc002sms.2_5'Flank|DOK1_uc010ffo.2_5'Flank|DOK1_uc002smt.2_5'Flank|DOK1_uc002smu.2_5'Flank|DOK1_uc010yrz.1_5'Flank|DOK1_uc002smv.2_5'Flank|DOK1_uc002smw.1_5'Flank	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	90	SRCR 1.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CCTGTGGCCTCTGTGAAGCCC	0.572													0	0	0	0.006122	0	16	85										G	74779494	C	G	74779494	3	3	22	1	0	0	0	0	1	0	0	0	8901	922	32	1	2045	1	LOXL3	2	74779494	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5777137	74779494	168419879	64	6261										
GGCX	2677	broad.mit.edu	37	chr2	85778102	85778102	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagatatgccaggtcttgctCcagtgcaagctctgtagtgt	11	10	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:85778102C>G	uc002sps.2	-	13	1940	c.1834G>C	c.(1834-1836)GAG>CAG	p.E612Q	GGCX_uc010yss.1_Missense_Mutation_p.E428Q|GGCX_uc010yst.1_Missense_Mutation_p.E555Q	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	612	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	AGGTCTTGCTCCAGTGCAAGC	0.453													0	0	0	0.00361	0	101	120										G	85778102	C	G	85778102	3	3	22	1	0	0	0	0	1	0	0	0	6356	864	30	1	454	1	GGCX	2	85778102	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	10998608	85778102	157421271	65	6262										
ANKRD36	375248	broad.mit.edu	37	chr2	97866233	97866233	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttttcgaatataaccagagAaaaaaaggatggagaaatat	8	3	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:97866233A>G	uc010yva.1	+	46	3072	c.2828A>G	c.(2827-2829)GAA>GGA	p.E943G	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	943											0						ATAACCAGAGAAAAAAAGGAT	0.323													0	0	0	0.004672	0	2	11										G	97866233	A	G	97866233	3	3	22	1	0	0	0	0	1	0	0	0	665	246	9	5	3010	5	ANKRD36	2	97866233	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	12088131	97866233	145333140	66	6263										
C2orf55	343990	broad.mit.edu	37	chr2	99463218	99463218	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gctgtcctccccaaggccttCtgcagcctcccgaagcttaa	8	17	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:99463218C>T	uc002szf.1	-	2	340	c.46G>A	c.(46-48)GAA>AAA	p.E16K		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	16											0						CCAAGGCCTTCTGCAGCCTCC	0.527													0	0	0	0.00361	0	43	76										T	99463218	C	T	99463218	3	4	22	1	0	0	0	0	1	0	0	0	2176	922	32	1	2878	1	C2orf55	2	99463218	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1596985	99463218	143736155	67	6264										
GPR45	11250	broad.mit.edu	37	chr2	105859329	105859329	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgcgaggcctgcatagagttGctgccccagaccttccaaat	10	14	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:105859329G>A	uc002tco.1	+	1	1130	c.1014G>A	c.(1012-1014)TTG>TTA	p.L338L		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	338	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GCATAGAGTTGCTGCCCCAGA	0.547													0	0	0	0.008871	0	21	195										A	105859329	G	A	105859329	2	1	22	1	0	0	0	0	0	0	0	1	6696	1310	46	2		2	GPR45	2	105859329	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6396111	105859329	137340044	68	6265										
BUB1	699	broad.mit.edu	37	chr2	111399043	111399043	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tatagaggttaatggcattcTaggaacaatggaaagtggaa	12	3	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:111399043T>C	uc002tgc.2	-	22	2738	c.2626_splice	c.e22-1	p.N876_splice	BUB1_uc010yxh.1_Splice_Site_p.N856_splice|BUB1_uc010fkb.2_Intron	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1						apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		AATGGCATTCTAGGAACAATG	0.403													0	0	0	0.006999	0	37	105										C	111399043	T	C	111399043	5	2	22	1	0	0	0	0	0	0	1	0	1570	1536	53	5	649	5	BUB1	2	111399043	Splice_Site	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	5539714	111399043	131800330	69	6266										
ZC3H6	376940	broad.mit.edu	37	chr2	113089651	113089651	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	attagtttgtatgaccctagGgatcacggttcatcatccac	8	10	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:113089651G>A	uc002thq.1	+	12	3550	c.3156G>A	c.(3154-3156)AGG>AGA	p.R1052R		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	1052							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						ATGACCCTAGGGATCACGGTT	0.453													0	0	0	0.005443	0	25	40										A	113089651	G	A	113089651	2	1	22	1	0	0	0	0	0	0	0	1	17568	1223	43	2		2	ZC3H6	2	113089651	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1690608	113089651	130109722	70	6267										
INSIG2	51141	broad.mit.edu	37	chr2	118854145	118854145	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atgaaaccatggcagaaggaGagacagagtcacctgggccc	13	10	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:118854145G>C	uc002tlk.2	+	2	219	c.13G>C	c.(13-15)GAG>CAG	p.E5Q	INSIG2_uc010yye.1_Intron	NM_016133	NP_057217	Q9Y5U4	INSI2_HUMAN	insulin induced protein 2	5					ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex		p.E5K(1)		ovary(1)|central_nervous_system(1)	2						GGCAGAAGGAGAGACAGAGTC	0.418													0	0	0	0.002299	0	24	54										C	118854145	G	C	118854145	3	2	22	1	0	0	0	0	1	0	0	0	7766	943	33	1	15	1	INSIG2	2	118854145	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5764494	118854145	124345228	71	6268										
PCDP1	200373	broad.mit.edu	37	chr2	120385260	120385260	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttcaaattcttcctgaggcgGatcagtcaggatgattatac	9	8	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:120385260G>C	uc002tmb.2	+	17	1782	c.690G>C	c.(688-690)CGG>CGC	p.R230R	PCDP1_uc010yyq.1_Silent_p.R360R	NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	516						cilium	calmodulin binding				0	Colorectal(110;0.196)					TCCTGAGGCGGATCAGTCAGG	0.483													0	0	0	0.009535	0	30	227										C	120385260	G	C	120385260	2	2	22	1	0	0	0	0	0	0	0	1	11572	1161	41	1		1	PCDP1	2	120385260	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1531115	120385260	122814113	72	6269										
PTPN4	5775	broad.mit.edu	37	chr2	120725515	120725515	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctagatattgtaagaacaatGagagatcagcgagccatgat	10	6	1	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:120725515G>A	uc002tmf.1	+	26	3432	c.2661G>A	c.(2659-2661)ATG>ATA	p.M887I	PTPN4_uc010flj.1_Missense_Mutation_p.M600I|PTPN4_uc010yyr.1_Missense_Mutation_p.M520I	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	887	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	TAAGAACAATGAGAGATCAGC	0.373													0	0	0	0.00361	0	52	85										A	120725515	G	A	120725515	3	1	22	1	0	0	0	0	1	0	0	0	12790	1290	45	1	2759	1	PTPN4	2	120725515	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	340255	120725515	122473858	73	6270										
GLI2	2736	broad.mit.edu	37	chr2	121747003	121747003	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccctttcctcagggcaacctGgcggtggtgcagcagaagcc	13	14	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:121747003G>C	uc010flp.2	+	13	3543	c.3513G>C	c.(3511-3513)CTG>CTC	p.L1171L	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.L843L|GLI2_uc002tmu.3_Silent_p.L826L	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1171					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGGGCAACCTGGCGGTGGTGC	0.632													0	0	0	0.000602	0	5	67										C	121747003	G	C	121747003	2	2	22	1	0	0	0	0	0	0	0	1	6438	1335	47	4		4	GLI2	2	121747003	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1021488	121747003	121452370	74	6271										
CCDC74A	90557	broad.mit.edu	37	chr2	132290451	132290451	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttcagctgcggcacctcaaGtccctcctggaagggagcca	11	14	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:132290451G>C	uc002tta.2	+	6	943	c.891G>C	c.(889-891)AAG>AAC	p.K297N	CCDC74A_uc002ttb.2_Missense_Mutation_p.K231N	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	297										skin(1)	1						GGCACCTCAAGTCCCTCCTGG	0.697													0	0	0	0.00308	0	8	97										C	132290451	G	C	132290451	3	2	22	1	0	0	0	0	1	0	0	0	2847	1020	36	4	913	4	CCDC74A	2	132290451	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10543448	132290451	110908922	75	6272										
LCT	3938	broad.mit.edu	37	chr2	136575162	136575163	+	Missense_Mutation	DNP	CC	CC	TG													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catgggctcgatgcccgcatCctgtagcctgtcaatcagct							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:136575162_136575163CC>TG	uc002tuu.1	-	6	1466_1467	c.1455_1456GG>CA	c.(1453-1458)CAGGAT>CACAAT	p.485_486QD>HN		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	485_486	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ATGCCCGCATCCTGTAGCCTGT	0.614													0	0	0	0.004672	0	9	86										TG	136575163	CC	TG	136575162	3	4	22	1	0	0	0	0	1	0	0	0	8693	855	30	1	4375	1	LCT	2	136575162	Missense_Mutation	DNP	CC	TCGA-BT-A42C-01A-11D-A23M-08	4284711	136575162	106624211	76	6273										
LRP1B	53353	broad.mit.edu	37	chr2	141092027	141092027	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtcagaaatcatacctgtgGgtctctgtaagttcttttgt	9	7	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:141092027G>A	uc002tvj.1	-	79	13190	c.12218C>T	c.(12217-12219)CCC>CTC	p.P4073L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4073	Extracellular (Potential).|LDL-receptor class B 35.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATACCTGTGGGTCTCTGTAA	0.363										TSP Lung(27;0.18)			0	0	0	0.002836	0	35	67										A	141092027	G	A	141092027	3	1	22	1	0	0	0	0	1	0	0	0	8955	1232	43	2	1633	2	LRP1B	2	141092027	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4516865	141092027	102107346	77	6274										
LRP1B	53353	broad.mit.edu	37	chr2	141130656	141130656	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cattttgctggtatacactgAccattggaacaccggaactg	9	10	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:141130656A>C	uc002tvj.1	-	69	11661	c.10689T>G	c.(10687-10689)GGT>GGG	p.G3563G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3563	Extracellular (Potential).|LDL-receptor class A 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATACACTGACCATTGGAAC	0.353										TSP Lung(27;0.18)			0	0	0	0.001984	0	7	98										C	141130656	A	C	141130656	2	2	22	1	0	0	0	0	0	0	0	1	8955	262	10	5		5	LRP1B	2	141130656	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	38629	141130656	102068717	78	6275										
ERMN	57471	broad.mit.edu	37	chr2	158178129	158178129	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catcatgtttagaatgtaacAtgtcagcttggctaggtttt	9	6	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:158178129A>G	uc002tzh.2	-	3	771	c.509T>C	c.(508-510)ATG>ACG	p.M170T	ERMN_uc010zcj.1_Missense_Mutation_p.M64T|ERMN_uc010zck.1_Missense_Mutation_p.M150T|ERMN_uc002tzi.2_Missense_Mutation_p.M183T	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	170						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						AGAATGTAACATGTCAGCTTG	0.353													0	0	0	0.006999	0	40	220										G	158178129	A	G	158178129	3	3	22	1	0	0	0	0	1	0	0	0	5235	217	8	5	349	5	ERMN	2	158178129	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	17047473	158178129	85021244	79	6276										
CCDC148	130940	broad.mit.edu	37	chr2	159035486	159035486	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctccatcaaacgcctttccaAtaattcttgtctatatttaa	2	11	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:159035486A>G	uc002tzq.2	-	12	1656	c.1393T>C	c.(1393-1395)TTG>CTG	p.L465L	CCDC148_uc002tzr.2_Silent_p.L313L|CCDC148_uc010foh.2_Silent_p.L178L	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	465										ovary(2)	2						CGCCTTTCCAATAATTCTTGT	0.403													0	0	0	0.004656	0	25	39										G	159035486	A	G	159035486	2	3	22	1	0	0	0	0	0	0	0	1	2782	98	4	5		5	CCDC148	2	159035486	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	857357	159035486	84163887	80	6277										
PKP4	8502	broad.mit.edu	37	chr2	159477589	159477589	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caggacagagccagaacaagGaaccctctattcaccagaac	8	13	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:159477589G>C	uc002tzv.2	+	5	628	c.368G>C	c.(367-369)GGA>GCA	p.G123A	PKP4_uc002tzt.1_5'UTR|PKP4_uc002tzu.2_Missense_Mutation_p.G123A|PKP4_uc002tzw.2_Missense_Mutation_p.G123A|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Missense_Mutation_p.G123A|PKP4_uc002uaa.2_5'UTR	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	123					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						CCAGAACAAGGAACCCTCTAT	0.408										HNSCC(62;0.18)			0	0	0	0.001168	0	6	102										C	159477589	G	C	159477589	3	2	22	1	0	0	0	0	1	0	0	0	11987	1174	41	1	382	1	PKP4	2	159477589	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	442103	159477589	83721784	81	6278										
BAZ2B	29994	broad.mit.edu	37	chr2	160257136	160257136	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aatttgctgagctcgaagttCtttttccattctgatttgct	7	8	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:160257136C>G	uc002uao.2	-	17	3224	c.2872G>C	c.(2872-2874)GAA>CAA	p.E958Q	BAZ2B_uc002uap.2_Missense_Mutation_p.E922Q|BAZ2B_uc002uaq.1_Missense_Mutation_p.E788Q	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	958	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GCTCGAAGTTCTTTTTCCATT	0.244													0	0	0	0.001368	0	13	39										G	160257136	C	G	160257136	3	3	22	1	0	0	0	0	1	0	0	0	1332	922	32	1	3718	1	BAZ2B	2	160257136	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	779547	160257136	82942237	82	6279										
SCN2A	6326	broad.mit.edu	37	chr2	166231228	166231228	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcttttaggagccattccaTctatcatgaatgtacttctg	6	10	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:166231228T>A	uc002udc.2	+	22	4296	c.4006T>A	c.(4006-4008)TCT>ACT	p.S1336T	SCN2A_uc002udd.2_Missense_Mutation_p.S1336T|SCN2A_uc002ude.2_Missense_Mutation_p.S1336T	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1336	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGCCATTCCATCTATCATGAA	0.333													0	0	0	0.00308	0	7	111										A	166231228	T	A	166231228	3	1	22	1	0	0	0	0	1	0	0	0	13916	1435	50	5	4184	5	SCN2A	2	166231228	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	5974092	166231228	76968145	83	6280										
MAP1D	254042	broad.mit.edu	37	chr2	172945092	172945092	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cacacggttctgatcacgtcGaggggcgcgcagatcctgac	13	13	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:172945092G>A	uc002uhk.2	+	10	1039	c.966G>A	c.(964-966)TCG>TCA	p.S322S	MAP1D_uc010zdw.1_Silent_p.S204S	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	322					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TGATCACGTCGAGGGGCGCGC	0.612													0	0	0	0.00361	0	255	167										A	172945092	G	A	172945092	2	1	22	1	0	0	0	0	0	0	0	1	9229	1045	37	1		1	MAP1D	2	172945092	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6713864	172945092	70254281	84	6281										
TTN	7273	broad.mit.edu	37	chr2	179417524	179417524	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtctttcattgagagatcacGtataggagctggtacttcag	11	7	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:179417524G>A	uc010zfg.1	-	284	82623	c.82399C>T	c.(82399-82401)CGT>TGT	p.R27467C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R21162C|TTN_uc010zfi.1_Missense_Mutation_p.R21095C|TTN_uc010zfj.1_Missense_Mutation_p.R20970C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28394							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGAGATCACGTATAGGAGCT	0.438													0	0	0	0.008291	0	10	100										A	179417524	G	A	179417524	3	1	22	1	0	0	0	0	1	0	0	0	16732	1145	40	2	17988	2	TTN	2	179417524	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6472432	179417524	63781849	85	6282										
PMS1	5378	broad.mit.edu	37	chr2	190718686	190718686	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taatccgacatcattacaatCtgaaatgcctaaaggaatct	5	9	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:190718686C>G	uc002urh.3	+	8	1373	c.844C>G	c.(844-846)CTG>GTG	p.L282V	PMS1_uc010zga.1_Missense_Mutation_p.L243V|PMS1_uc010zgb.1_Missense_Mutation_p.L221V|PMS1_uc002urk.3_Missense_Mutation_p.L243V|PMS1_uc002uri.3_Missense_Mutation_p.L282V|PMS1_uc010zgc.1_Missense_Mutation_p.L106V|PMS1_uc010zgd.1_Missense_Mutation_p.L106V|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.L243V|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.L67V|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Translation_Start_Site	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	282					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TCATTACAATCTGAAATGCCT	0.279			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					0	0	0	0.00308	0	6	57										G	190718686	C	G	190718686	3	3	22	1	0	0	0	0	1	0	0	0	12142	912	32	1	870	1	PMS1	2	190718686	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	11301162	190718686	52480687	86	6283										
PMS1	5378	broad.mit.edu	37	chr2	190718983	190718983	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aggaatctgttttaattgctCttgaaaatctgatgacgact	8	6	3	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:190718983C>T	uc002urh.3	+	9	1514	c.985C>T	c.(985-987)CTT>TTT	p.L329F	PMS1_uc010zga.1_Missense_Mutation_p.L290F|PMS1_uc010zgb.1_Missense_Mutation_p.L268F|PMS1_uc002urk.3_Missense_Mutation_p.L290F|PMS1_uc002uri.3_Missense_Mutation_p.L329F|PMS1_uc010zgc.1_Missense_Mutation_p.L153F|PMS1_uc010zgd.1_Missense_Mutation_p.L153F|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.L290F|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Missense_Mutation_p.L114F|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_5'UTR	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	329					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			TTTAATTGCTCTTGAAAATCT	0.254			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					0	0	0	0.004482	0	9	47										T	190718983	C	T	190718983	3	4	22	1	0	0	0	0	1	0	0	0	12142	913	32	1	1015	1	PMS1	2	190718983	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	297	190718983	52480390	87	6284										
MDH1B	130752	broad.mit.edu	37	chr2	207619970	207619970	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcttcggaggcagtcctccaGagtgaacacctccttgttgg	12	12	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:207619970G>C	uc002vbs.2	-	5	728	c.673C>G	c.(673-675)CTG>GTG	p.L225V	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.L225V|MDH1B_uc010fuj.2_Missense_Mutation_p.L127V|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	225					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CAGTCCTCCAGAGTGAACACC	0.577													0	0	0	0.00874	0	44	35										C	207619970	G	C	207619970	3	2	22	1	0	0	0	0	1	0	0	0	9409	933	33	1	915	1	MDH1B	2	207619970	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16900987	207619970	35579403	88	6285										
KIAA1486	57624	broad.mit.edu	37	chr2	226447337	226447337	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aagagcaggccgcggccctgGgacctgcctctgccacccct	12	18	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr2:226447337G>C	uc002voe.2	+	4	1379	c.1204G>C	c.(1204-1206)GGA>CGA	p.G402R	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.G172R	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	402	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CGCGGCCCTGGGACCTGCCTC	0.667													0	0	0	0.000602	0	5	4										C	226447337	G	C	226447337	3	2	22	1	0	0	0	0	1	0	0	0	8237	1233	43	4	1214	4	KIAA1486	2	226447337	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	18827367	226447337	16752036	89	6286										
TSEN2	80746	broad.mit.edu	37	chr3	12571305	12571305	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgatgaccattttgaaggctCtctccgcaggcctctcagtt	9	12	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:12571305C>G	uc003bxc.2	+	10	1568	c.1181C>G	c.(1180-1182)TCT>TGT	p.S394C	TSEN2_uc003bwz.2_Missense_Mutation_p.S335C|TSEN2_uc003bxa.2_Missense_Mutation_p.S368C|TSEN2_uc011auq.1_Missense_Mutation_p.S368C|TSEN2_uc003bxb.2_Missense_Mutation_p.S394C|TSEN2_uc011aur.1_Missense_Mutation_p.S303C	NM_025265	NP_079541	Q8NCE0	SEN2_HUMAN	tRNA-intron nuclease 2 isoform 1	394					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(1)	1						TTTGAAGGCTCTCTCCGCAGG	0.403													0	0	0	0.00361	0	56	120										G	12571305	C	G	12571305	3	3	22	1	0	0	0	0	1	0	0	0	16609	913	32	1	1215	1	TSEN2	3	12571305	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		12571305	185451125	90	6287										
ZNF445	353274	broad.mit.edu	37	chr3	44490077	44490077	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atgggattttcacattgatcCttctgcctgctcttctgttg	8	10	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:44490077C>T	uc003cnf.2	-	8	1434	c.1086G>A	c.(1084-1086)AAG>AAA	p.K362K	ZNF445_uc011azv.1_Silent_p.K350K|ZNF445_uc011azw.1_Silent_p.K362K	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	362					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CACATTGATCCTTCTGCCTGC	0.418													0	0	0	0.004007	0	16	80										T	44490077	C	T	44490077	2	4	22	1	0	0	0	0	0	0	0	1	17915	680	24	2		2	ZNF445	3	44490077	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	31918772	44490077	153532353	91	6288										
WDR82	80335	broad.mit.edu	37	chr3	52294439	52294439	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtcataaagcttgaccatttCagagttgacacctgcagcga	9	10	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:52294439C>T	uc003ddl.2	-	5	787	c.505G>A	c.(505-507)GAA>AAA	p.E169K	WDR82_uc003ddk.2_Missense_Mutation_p.E94K	NM_025222	NP_079498	Q6UXN9	WDR82_HUMAN	WD repeat domain 82	169	WD 3.				histone H3-K4 methylation	chromatin|PTW/PP1 phosphatase complex|Set1C/COMPASS complex	protein binding				0				BRCA - Breast invasive adenocarcinoma(193;2.67e-05)|Kidney(197;0.00198)|KIRC - Kidney renal clear cell carcinoma(197;0.00223)|OV - Ovarian serous cystadenocarcinoma(275;0.246)		TTGACCATTTCAGAGTTGACA	0.338													0	0	0	0.003163	0	15	47										T	52294439	C	T	52294439	3	4	22	1	0	0	0	0	1	0	0	0	17328	835	29	1	456	1	WDR82	3	52294439	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	7804362	52294439	145727991	92	6289										
DNAH1	25981	broad.mit.edu	37	chr3	52398863	52398863	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgcaggagctgatctgcctCcgggccatccgtgatgtgaa	13	12	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:52398863C>G	uc011bef.1	+	34	5607	c.5346C>G	c.(5344-5346)CTC>CTG	p.L1782L		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1782					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGATCTGCCTCCGGGCCATCC	0.637													0	0	0	0.004007	0	16	51										G	52398863	C	G	52398863	2	3	22	1	0	0	0	0	0	0	0	1	4597	842	30	1		1	DNAH1	3	52398863	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	104424	52398863	145623567	93	6290										
GNL3	26354	broad.mit.edu	37	chr3	52725636	52725636	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taatgttggtgtatccatggGgcttacaaggtaaatggagg	14	4	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:52725636G>A	uc003dfd.2	+	9	1033	c.860G>A	c.(859-861)GGG>GAG	p.G287E	GNL3_uc003dfe.2_Missense_Mutation_p.G275E|GNL3_uc003dff.2_Missense_Mutation_p.G275E|SNORD69_uc003dfh.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	287	G.|Intermediate (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		GTATCCATGGGGCTTACAAGG	0.323													0	0	0	0.001168	0	5	31										A	52725636	G	A	52725636	3	1	22	1	0	0	0	0	1	0	0	0	6537	1232	43	2	894	2	GNL3	3	52725636	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	326773	52725636	145296794	94	6291										
ACOX2	8309	broad.mit.edu	37	chr3	58519231	58519231	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtgtatcacaaactcctggGtggctgcgtcataggtggct	13	9	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:58519231G>T	uc003dkl.2	-	5	699	c.524C>A	c.(523-525)ACC>AAC	p.T175N		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	175					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		AAACTCCTGGGTGGCTGCGTC	0.542											OREG0015638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.80697e-09	0.010729	3.04741e-09	10	144										T	58519231	G	T	58519231	3	4	22	1	0	0	0	0	1	0	0	0	159	1261	44	4	1565	4	ACOX2	3	58519231	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5793595	58519231	139503199	95	6292										
FOXP1	27086	broad.mit.edu	37	chr3	71050168	71050168	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgcatttgtactctacattgGgctgtacttctatcgtccag	8	10	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:71050168G>T	uc003dol.2	-	9	1340	c.1017C>A	c.(1015-1017)GCC>GCA	p.A339A	FOXP1_uc003dom.2_Silent_p.A263A|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Silent_p.A339A|FOXP1_uc003dop.2_Silent_p.A339A|FOXP1_uc003doq.1_Silent_p.A338A|FOXP1_uc003doi.2_Silent_p.A239A|FOXP1_uc003doj.2_Silent_p.A239A|FOXP1_uc003dok.2_Silent_p.A152A|FOXP1_uc003dor.1_Silent_p.A117A	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	339					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		CTCTACATTGGGCTGTACTTC	0.353			T	PAX5	ALL								1	0	0.00741294	0.007413	0.00756564	17	74										T	71050168	G	T	71050168	2	4	22	1	0	0	0	0	0	0	0	1	6026	1219	43	4		4	FOXP1	3	71050168	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	12530937	71050168	126972262	96	6293										
DPPA2	151871	broad.mit.edu	37	chr3	109027098	109027098	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cactgccttgcgtttcctcgAacatcgctgtaatctggtct	8	13	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:109027098A>C	uc003dxo.2	-	6	686	c.439T>G	c.(439-441)TCG>GCG	p.S147A		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	147						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						CGTTTCCTCGAACATCGCTGT	0.433													0	0	0	0.001368	0	13	116										C	109027098	A	C	109027098	3	2	22	1	0	0	0	0	1	0	0	0	4734	246	9	5	469	5	DPPA2	3	109027098	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	37976930	109027098	88995332	97	6294										
SIDT1	54847	broad.mit.edu	37	chr3	113303564	113303564	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaaaaggaaaaccagacctgGaatctacagcgaaaaaagaa	9	7	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:113303564G>C	uc003eak.2	+	8	1506	c.855G>C	c.(853-855)TGG>TGC	p.W285C	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.W285C|SIDT1_uc011big.1_Missense_Mutation_p.W38C	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	285	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						ACCAGACCTGGAATCTACAGC	0.358													0	0	0	0.001368	0	10	96										C	113303564	G	C	113303564	3	2	22	1	0	0	0	0	1	0	0	0	14302	1183	41	1	885	1	SIDT1	3	113303564	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4276466	113303564	84718866	98	6295										
IGSF11	152404	broad.mit.edu	37	chr3	118623621	118623621	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagtgccaatggctccagctAttagtccaatgttcctgggc	10	12	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:118623621A>G	uc003ebw.2	-	6	975	c.728T>C	c.(727-729)ATA>ACA	p.I243T	IGSF11_uc011biv.1_Intron|IGSF11_uc003ebx.2_Missense_Mutation_p.I219T|IGSF11_uc003eby.2_Missense_Mutation_p.I242T|IGSF11_uc003ebz.2_Missense_Mutation_p.I218T|IGSF11_uc010hqs.2_Missense_Mutation_p.I242T	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	243	Helical; (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						GGCTCCAGCTATTAGTCCAAT	0.358													0	0	0	0.00361	0	59	248										G	118623621	A	G	118623621	3	3	22	1	0	0	0	0	1	0	0	0	7598	449	16	5	575	5	IGSF11	3	118623621	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	5320057	118623621	79398809	99	6296										
KALRN	8997	broad.mit.edu	37	chr3	124436142	124436142	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cttatgaatcatgatgaactGatggaggaaaaagtagcttt	10	4	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:124436142G>A	uc003ehg.2	+	59	8452	c.8325G>A	c.(8323-8325)CTG>CTA	p.L2775L	KALRN_uc003ehk.2_Silent_p.L1078L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2774	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGATGAACTGATGGAGGAAA	0.413													0	0	0	0.00361	0	71	82										A	124436142	G	A	124436142	2	1	22	1	0	0	0	0	0	0	0	1	7975	1277	45	1		1	KALRN	3	124436142	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5812521	124436142	73586288	100	6297										
UROC1	131669	broad.mit.edu	37	chr3	126208204	126208204	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acgtcatggtgatctcggctCaggaccaccggcgcctgtgc	13	14	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:126208204C>T	uc003eiz.1	-	17	1655	c.1623G>A	c.(1621-1623)CTG>CTA	p.L541L	UROC1_uc010hsi.1_Silent_p.L601L	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	541					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		GATCTCGGCTCAGGACCACCG	0.582													0	0	0	0.00361	0	87	148										T	126208204	C	T	126208204	2	4	22	1	0	0	0	0	0	0	0	1	17025	813	29	1		1	UROC1	3	126208204	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1772062	126208204	71814226	101	6298										
ACAD11	84129	broad.mit.edu	37	chr3	132337486	132337486	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taatgtagtaacctggtgctTggcagttaaagacatctgga	11	6	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:132337486T>C	uc003eov.3	-	11	1786	c.1406A>G	c.(1405-1407)CAA>CGA	p.Q469R	ACAD11_uc011blr.1_Missense_Mutation_p.Q80R|ACAD11_uc003eoy.2_Missense_Mutation_p.Q469R	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	469						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						ACCTGGTGCTTGGCAGTTAAA	0.338													0	0	0	0.003163	0	15	75										C	132337486	T	C	132337486	3	2	22	1	0	0	0	0	1	0	0	0	109	1812	63	5	976	5	ACAD11	3	132337486	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	6129282	132337486	65684944	102	6299										
RAB6B	51560	broad.mit.edu	37	chr3	133614257	133614257	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttaccgctctgctcccccaaGaacaccaacttgaattttct	4	15	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:133614257G>T	uc003epy.2	-	1	435	c.54C>A	c.(52-54)TTC>TTA	p.F18L	RAB6B_uc011blu.1_5'UTR	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	18					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						GCTCCCCCAAGAACACCAACT	0.507													1	0	7.25294e-45	0.00361	8.46435e-45	68	60										T	133614257	G	T	133614257	3	4	22	1	0	0	0	0	1	0	0	0	12952	933	33	3	604	3	RAB6B	3	133614257	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1276771	133614257	64408173	103	6300										
ZIC4	84107	broad.mit.edu	37	chr3	147113765	147113765	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgatttacaagtttgtattTggctttgaagggctttccct	10	6	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:147113765T>G	uc003ewd.1	-	3	835	c.562A>C	c.(562-564)AAA>CAA	p.K188Q	ZIC4_uc003ewc.1_Missense_Mutation_p.K118Q|ZIC4_uc011bno.1_Missense_Mutation_p.K238Q	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	188	C2H2-type 2; atypical.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGTTTGTATTTGGCTTTGAAG	0.572													0	0	0	0.010818	0	30	367										G	147113765	T	G	147113765	3	3	22	1	0	0	0	0	1	0	0	0	17678	1821	63	5	454	5	ZIC4	3	147113765	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	13499508	147113765	50908665	104	6301										
PLCH1	23007	broad.mit.edu	37	chr3	155208658	155208658	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcaacaaaagggtcaatgatCtattaagtaaagagaaagta	8	4	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:155208658C>G	uc011bok.1	-	18	2549	c.2272_splice	c.e18-1	p.I758_splice	PLCH1_uc011boj.1_Splice_Site_p.I758_splice|PLCH1_uc011bol.1_Splice_Site_p.I740_splice	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a						lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGTCAATGATCTATTAAGTAA	0.313													0	0	0	0.001168	0	6	48										G	155208658	C	G	155208658	5	3	22	1	0	0	0	0	0	0	1	0	12037	927	32	1	2849	1	PLCH1	3	155208658	Splice_Site	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	8094893	155208658	42813772	105	6302										
MECOM	2122	broad.mit.edu	37	chr3	168833343	168833348	+	In_Frame_Del	DEL	GGGGCT	GGGGCT	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actgcccatacttagatccaGgggctggtcttggcttgtgg							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:168833343_168833348delGGGGCT	uc003ffi.3	-	7	2017_2022	c.1748_1753delAGCCCC	c.(1747-1755)CAGCCCCTG>CTG	p.QP583del	MECOM_uc010hwk.1_In_Frame_Del_p.QP606del|MECOM_uc003ffj.3_In_Frame_Del_p.QP648del|MECOM_uc011bpi.1_In_Frame_Del_p.QP584del|MECOM_uc003ffn.3_In_Frame_Del_p.QP583del|MECOM_uc003ffk.2_In_Frame_Del_p.QP583del|MECOM_uc003ffl.2_In_Frame_Del_p.QP743del|MECOM_uc011bpj.1_In_Frame_Del_p.QP771del|MECOM_uc011bpk.1_In_Frame_Del_p.QP573del|MECOM_uc010hwn.2_In_Frame_Del_p.QP771del	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	583_584	CTBP-binding motif 2 (By similarity).				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CTTAGATCCAGGGGCTGGTCTTGGCT	0.534																		15	170	---	---								-	168833348	GGGGCT	-	168833343	7	5	22	1	0	1	0	1	0	0	0	0	9422	991	35	0	1442	0	MECOM	3	168833343	In_Frame_Del	DEL	GGGGCT	TCGA-BT-A42C-01A-11D-A23M-08	13624685	168833343	29189087	106	6303										
ECT2	1894	broad.mit.edu	37	chr3	172472376	172472376	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaggactagcttggcagactCttccatttttgattctaaag	9	8	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:172472376C>G	uc003fii.2	+	2	194	c.56C>G	c.(55-57)TCT>TGT	p.S19C	ECT2_uc010hwv.1_Missense_Mutation_p.S19C|ECT2_uc003fih.2_Missense_Mutation_p.S19C|ECT2_uc003fij.1_Missense_Mutation_p.S19C|ECT2_uc003fik.1_Missense_Mutation_p.S19C|ECT2_uc003fil.1_Missense_Mutation_p.S19C	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	19					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			TTGGCAGACTCTTCCATTTTT	0.323													0	0	0	0.001368	0	13	17										G	172472376	C	G	172472376	3	3	22	1	0	0	0	0	1	0	0	0	4901	913	32	1	58	1	ECT2	3	172472376	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	3639033	172472376	25550054	107	6304										
ECT2	1894	broad.mit.edu	37	chr3	172472419	172472419	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actgagatttccaaggaaaaCttacttattggatctacttc	6	8	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:172472419C>G	uc003fii.2	+	2	237	c.99C>G	c.(97-99)AAC>AAG	p.N33K	ECT2_uc010hwv.1_Missense_Mutation_p.N33K|ECT2_uc003fih.2_Missense_Mutation_p.N33K|ECT2_uc003fij.1_Missense_Mutation_p.N33K|ECT2_uc003fik.1_Missense_Mutation_p.N33K|ECT2_uc003fil.1_Missense_Mutation_p.N33K	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	33					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CCAAGGAAAACTTACTTATTG	0.323													0	0	0	0.00499	0	17	15										G	172472419	C	G	172472419	3	3	22	1	0	0	0	0	1	0	0	0	4901	564	20	4	101	4	ECT2	3	172472419	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	43	172472419	25550011	108	6305										
ABCC5	10057	broad.mit.edu	37	chr3	183670874	183670874	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccatttatgagtaaccttacCccgcttccttgcttgatcca	5	14	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:183670874C>T	uc003fmg.2	-	18	2832	c.2667G>A	c.(2665-2667)GGG>GGA	p.G889G	ABCC5_uc011bqt.1_Silent_p.G417G|ABCC5_uc010hxl.2_Silent_p.G889G	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	889	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GTAACCTTACCCCGCTTCCTT	0.463													0	0	0	0.00361	0	57	109										T	183670874	C	T	183670874	2	4	22	1	0	0	0	0	0	0	0	1	56	637	22	2		2	ABCC5	3	183670874	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	11198455	183670874	14351556	109	6306										
THPO	7066	broad.mit.edu	37	chr3	184090596	184090596	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caggaaagagtccacgagttCcattcaagagttcgtgtatc	10	9	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:184090596C>A	uc003fol.1	-	6	982	c.767G>T	c.(766-768)GGA>GTA	p.G256V	THPO_uc003fom.1_Missense_Mutation_p.G252V|THPO_uc003fon.2_Missense_Mutation_p.W217C|THPO_uc011bro.1_Intron|THPO_uc003fop.2_Missense_Mutation_p.W213C|THPO_uc011brp.1_Intron|THPO_uc011brq.1_Missense_Mutation_p.W177C	NM_000460	NP_000451	P40225	TPO_HUMAN	thrombopoietin precursor	256					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			ovary(1)	1	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCCACGAGTTCCATTCAAGAG	0.562													1	0	2.60632e-51	0.00361	3.04816e-51	91	286										A	184090596	C	A	184090596	3	1	22	1	0	0	0	0	1	0	0	0	15869	856	30	3	298	3	THPO	3	184090596	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	419722	184090596	13931834	110	6307										
DGKG	1608	broad.mit.edu	37	chr3	186015941	186015941	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggctgaaggccaggaagagGtgagtgctcagtggctgggg	20	6	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr3:186015941G>A	uc003fqa.2	-	4	759	c.222C>T	c.(220-222)CAC>CAT	p.H74H	DGKG_uc003fqb.2_Silent_p.H74H|DGKG_uc003fqc.2_Silent_p.H74H|DGKG_uc011brx.1_Silent_p.H74H	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	74					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCAGGAAGAGGTGAGTGCTCA	0.527													0	0	0	0.009535	0	33	211										A	186015941	G	A	186015941	2	1	22	1	0	0	0	0	0	0	0	1	4469	1252	44	2		2	DGKG	3	186015941	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1925345	186015941	12006489	111	6308										
FGFR3	2261	broad.mit.edu	37	chr4	1806099	1806099	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgacgaggcgggcagtgtgtAtgcaggcatcctcagctacg	15	10	1	1	rs121913485		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:1806099A>G	uc003gdr.3	+	9	1374	c.1118A>G	c.(1117-1119)TAT>TGT	p.Y373C	FGFR3_uc003gdu.2_Missense_Mutation_p.Y375C|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.Y373C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	373	Extracellular (Potential).		Y -> C (in KERSEB and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.Y373C(437)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGCAGTGTGTATGCAGGCATC	0.682	Y373C(KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00361	0	159	67										G	1806099	A	G	1806099	3	3	22	1	0	0	0	0	1	0	0	0	5867	449	16	5	1303	5	FGFR3	4	1806099	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08		1806099	189348177	112	6309										
C1QTNF7	114905	broad.mit.edu	37	chr4	15437374	15437374	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttccagagccaaagatgtttGtcttgctctatgttacaagt	8	8	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:15437374G>C	uc011bxb.1	+	2	234	c.7G>C	c.(7-9)GTC>CTC	p.V3L	C1QTNF7_uc003gno.2_Missense_Mutation_p.V10L|C1QTNF7_uc003gnp.2_Missense_Mutation_p.V3L	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	3						collagen					0						AAAGATGTTTGTCTTGCTCTA	0.448													0	0	0	0.009096	0	4	68										C	15437374	G	C	15437374	3	2	22	1	0	0	0	0	1	0	0	0	1968	1377	48	4	34	4	C1QTNF7	4	15437374	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	13631275	15437374	175716902	113	6310										
CD38	952	broad.mit.edu	37	chr4	15780060	15780060	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggccaactgcgagttcagccCggtgtccggggacaaaccct	13	14	1	0	rs78988986	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:15780060C>A	uc011bxc.1	+	1	130	c.23C>A	c.(22-24)CCG>CAG	p.P8Q	CD38_uc003goj.1_Missense_Mutation_p.P8Q|CD38_uc003gol.1_Missense_Mutation_p.P8Q	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	8	Cytoplasmic (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2						GAGTTCAGCCCGGTGTCCGGG	0.647													1	0	5.20006e-24	0.011902	5.89196e-24	43	96										A	15780060	C	A	15780060	3	1	22	1	0	0	0	0	1	0	0	0	3009	652	23	4	25	4	CD38	4	15780060	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	342686	15780060	175374216	114	6311										
SLC34A2	10568	broad.mit.edu	37	chr4	25677816	25677816	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttgctgtggtacccgatcccGttcactcgcctgcccatccg	9	17	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:25677816G>A	uc003grr.2	+	13	1599	c.1518G>A	c.(1516-1518)CCG>CCA	p.P506P	SLC34A2_uc003grs.2_Silent_p.P505P|SLC34A2_uc010iev.2_Silent_p.P505P	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	506	Helical; Name=M6; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				ACCCGATCCCGTTCACTCGCC	0.567													0	0	0	0.012213	0	34	121										A	25677816	G	A	25677816	2	1	22	1	0	0	0	0	0	0	0	1	14568	1132	40	2		2	SLC34A2	4	25677816	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	9897756	25677816	165476460	115	6312										
DCAF4L1	285429	broad.mit.edu	37	chr4	41984468	41984468	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcgacgggacaccagcagtCatttgataccagcagtgatg	13	10	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:41984468C>G	uc003gwk.2	+	1	756	c.659C>G	c.(658-660)TCA>TGA	p.S220*		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	220										skin(1)	1						CACCAGCAGTCATTTGATACC	0.552													0	0	0	0.00361	0	70	262										G	41984468	C	G	41984468	4	3	22	1	0	0	0	0	0	1	0	0	4271	838	29	1	661	1	DCAF4L1	4	41984468	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	16306652	41984468	149169808	116	6313										
GABRB1	2560	broad.mit.edu	37	chr4	47033934	47033934	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctacttcttccccttagcacCaatgaacccagcaacatgtc	4	16	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:47033934C>T	uc003gxh.2	+	2	458	c.84C>T	c.(82-84)ACC>ACT	p.T28T	GABRB1_uc011bze.1_5'UTR|GABRB1_uc011bzd.1_Silent_p.T28T|GABRB1_uc010igg.2_RNA	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	28	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCCTTAGCACCAATGAACCCA	0.458													0	0	0	0.00278	0	21	258										T	47033934	C	T	47033934	2	4	22	1	0	0	0	0	0	0	0	1	6166	581	21	2		2	GABRB1	4	47033934	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5049466	47033934	144120342	117	6314										
SCD5	79966	broad.mit.edu	37	chr4	83557961	83557961	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acaaagcacatgagcaccacGgagatcttatagtacctaca	7	11	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:83557961G>A	uc003hna.2	-	4	905	c.585C>T	c.(583-585)TCC>TCT	p.S195S		NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	195	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				TGAGCACCACGGAGATCTTAT	0.517													0	0	0	0.010504	0	21	19										A	83557961	G	A	83557961	2	1	22	1	0	0	0	0	0	0	0	1	13887	1103	39	2		2	SCD5	4	83557961	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	36524027	83557961	107596315	118	6315										
WDFY3	23001	broad.mit.edu	37	chr4	85672647	85672647	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttctttacctccaacaaaaGatcaattagtggagtttgct	6	8	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:85672647G>C	uc003hpd.2	-	36	6370	c.5962C>G	c.(5962-5964)CTT>GTT	p.L1988V		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1988						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCAACAAAAGATCAATTAGT	0.358													0	0	0	0.00245	0	14	72										C	85672647	G	C	85672647	3	2	22	1	0	0	0	0	1	0	0	0	17267	942	33	1	4750	1	WDFY3	4	85672647	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2114686	85672647	105481629	119	6316										
WDFY3	23001	broad.mit.edu	37	chr4	85672677	85672677	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggagtttgcttgctggcagGagtgagacagaggttgtcta	16	5	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:85672677G>C	uc003hpd.2	-	36	6340	c.5932C>G	c.(5932-5934)CCT>GCT	p.P1978A		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1978						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGCTGGCAGGAGTGAGACAG	0.388													0	0	0	0.003163	0	14	90										C	85672677	G	C	85672677	3	2	22	1	0	0	0	0	1	0	0	0	17267	1174	41	1	4780	1	WDFY3	4	85672677	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	30	85672677	105481599	120	6317										
KLHL8	57563	broad.mit.edu	37	chr4	88097923	88097923	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atctacctctttgtgttcatTgatgccttcatcatccattt	4	11	5	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:88097923T>G	uc011cdb.1	-	6	1579	c.1194A>C	c.(1192-1194)TCA>TCC	p.S398S	KLHL8_uc003hql.1_Silent_p.S398S|KLHL8_uc003hqm.1_Silent_p.S322S|KLHL8_uc003hqn.1_Silent_p.S215S|KLHL8_uc010ikj.1_Silent_p.S47S	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	398	Kelch 2.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TTGTGTTCATTGATGCCTTCA	0.338													0	0	0	0.012319	0	22	65										G	88097923	T	G	88097923	2	3	22	1	0	0	0	0	0	0	0	1	8395	1799	63	5		5	KLHL8	4	88097923	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	2425246	88097923	103056353	121	6318										
AGXT2L1	64850	broad.mit.edu	37	chr4	109663675	109663675	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cttactgagcagtgaatgtgTatccgtgcacattccatttc	8	10	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:109663675T>G	uc003hzc.2	-	13	1646	c.1465A>C	c.(1465-1467)ACA>CCA	p.T489P	AGXT2L1_uc010imc.2_Missense_Mutation_p.T483P|AGXT2L1_uc011cfm.1_Missense_Mutation_p.T449P|AGXT2L1_uc011cfn.1_Missense_Mutation_p.T416P|AGXT2L1_uc011cfo.1_Missense_Mutation_p.T431P	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	489					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		AGTGAATGTGTATCCGTGCAC	0.438													0	0	0	0.00499	0	16	127										G	109663675	T	G	109663675	3	3	22	1	0	0	0	0	1	0	0	0	406	1638	57	5	38	5	AGXT2L1	4	109663675	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	21565752	109663675	81490601	122	6319										
SYNPO2	171024	broad.mit.edu	37	chr4	119951548	119951548	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgacttcttaccaaagaaagGaggaagagtcggtaagaacg	12	7	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:119951548G>C	uc003icm.3	+	4	1814	c.1618G>C	c.(1618-1620)GAG>CAG	p.E540Q	SYNPO2_uc010ina.2_Missense_Mutation_p.E540Q|SYNPO2_uc010inb.2_Missense_Mutation_p.E540Q|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.E468Q	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	540						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						CCAAAGAAAGGAGGAAGAGTC	0.517													0	0	0	0.00361	0	53	54										C	119951548	G	C	119951548	3	2	22	1	0	0	0	0	1	0	0	0	15454	1175	41	1	1632	1	SYNPO2	4	119951548	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10287873	119951548	71202728	123	6320										
SPATA5	166378	broad.mit.edu	37	chr4	123855676	123855676	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actgaagaagagagactgctAaagttcagcataggagcaaa	11	6	1	4	rs141742510	by1000genomes	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:123855676A>G	uc003iez.3	+	5	1003	c.930A>G	c.(928-930)CTA>CTG	p.L310L	SPATA5_uc003iey.2_Silent_p.L309L	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	310					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						AGAGACTGCTAAAGTTCAGCA	0.348													0	0	0	0.00245	0	14	64										G	123855676	A	G	123855676	2	3	22	1	0	0	0	0	0	0	0	1	15010	349	13	5		5	SPATA5	4	123855676	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	3904128	123855676	67298600	124	6321										
UCP1	7350	broad.mit.edu	37	chr4	141489011	141489011	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcggagctgatttgccgctGaagccccgcaggcagcccgc	15	15	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:141489011G>A	uc011chj.1	-	2	323	c.247C>T	c.(247-249)CAG>TAG	p.Q83*	UCP1_uc011chk.1_Nonsense_Mutation_p.Q83*	NM_021833	NP_068605	P25874	UCP1_HUMAN	uncoupling protein 1	83	Solcar 1.|Helical; Name=2; (Potential).				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	all_hematologic(180;0.162)					ATTTGCCGCTGAAGCCCCGCA	0.562													0	0	0	0.00632	0	28	136										A	141489011	G	A	141489011	4	1	22	1	0	0	0	0	0	1	0	0	16927	1299	45	1	694	1	UCP1	4	141489011	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	17633335	141489011	49665265	125	6322										
TBC1D9	23158	broad.mit.edu	37	chr4	141600892	141600892	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gttgacgagtttctcttcctCtggcatcccaaacagcctat	7	13	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:141600892C>G	uc010ioj.2	-	4	738	c.466G>C	c.(466-468)GAG>CAG	p.E156Q		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	156	GRAM 1.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTCTCTTCCTCTGGCATCCCA	0.423													0	0	0	0.007413	0	18	25										G	141600892	C	G	141600892	3	3	22	1	0	0	0	0	1	0	0	0	15624	922	32	1	3406	1	TBC1D9	4	141600892	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	111881	141600892	49553384	126	6323										
EDNRA	1909	broad.mit.edu	37	chr4	148406949	148406949	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcatgtggatgatttcaccaCttttcgtggcacagagctca	9	10	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:148406949C>A	uc003iky.2	+	2	808	c.116C>A	c.(115-117)ACT>AAT	p.T39N	EDNRA_uc011cid.1_Intron|EDNRA_uc010ipe.1_Missense_Mutation_p.T39N|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Missense_Mutation_p.T39N	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	39	Extracellular (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GATTTCACCACTTTTCGTGGC	0.473													1	0	1.04594e-18	0.00623	1.17533e-18	41	65										A	148406949	C	A	148406949	3	1	22	1	0	0	0	0	1	0	0	0	4919	565	20	4	118	4	EDNRA	4	148406949	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6806057	148406949	42747327	127	6324										
RAPGEF2	9693	broad.mit.edu	37	chr4	160271403	160271403	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaatgcatcttcgcagctttCttctcctcctacttctccac	3	16	4	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:160271403C>G	uc003iqg.3	+	20	3654	c.3344C>G	c.(3343-3345)TCT>TGT	p.S1115C		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1115	Ser-rich.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TCGCAGCTTTCTTCTCCTCCT	0.333													0	0	0	0.010729	0	10	29										G	160271403	C	G	160271403	3	3	22	1	0	0	0	0	1	0	0	0	13044	913	32	1	3422	1	RAPGEF2	4	160271403	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	11864454	160271403	30882873	128	6325										
SPATA4	132851	broad.mit.edu	37	chr4	177116553	177116553	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctgaagccaacgcagaacgGaacgagacaagcgggagctc	13	12	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:177116553G>T	uc003iuo.1	-	1	270	c.161C>A	c.(160-162)TCC>TAC	p.S54Y		NM_144644	NP_653245	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	54					apoptosis|spermatogenesis						0		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		ACGCAGAACGGAACGAGACAA	0.607													1	0	2.97807e-44	0.00361	3.46805e-44	73	91										T	177116553	G	T	177116553	3	4	22	1	0	0	0	0	1	0	0	0	15009	1174	41	3	780	3	SPATA4	4	177116553	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16845150	177116553	14037723	129	6326										
ING2	3622	broad.mit.edu	37	chr4	184431737	184431737	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cccgcaggcagcggaccagtGaaagccgtgatttatgtcac	12	12	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr4:184431737G>A	uc003ivs.1	+	2	604	c.475G>A	c.(475-477)GAA>AAA	p.E159K	ING2_uc011ckk.1_Missense_Mutation_p.E119K	NM_001564	NP_001555	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	159					chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			ovary(1)	1		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GCGGACCAGTGAAAGCCGTGA	0.458													0	0	0	0.005524	0	38	48										A	184431737	G	A	184431737	3	1	22	1	0	0	0	0	1	0	0	0	7736	1291	45	1	481	1	ING2	4	184431737	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	7315184	184431737	6722539	130	6327										
CDH18	1016	broad.mit.edu	37	chr5	19473804	19473804	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cttttttgctgcgcctcaggGtgataaaaagtaccacaatt	8	9	1	1	rs147821413		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:19473804G>A	uc003jgc.2	-	12	2281	c.1904C>T	c.(1903-1905)ACC>ATC	p.T635I	CDH18_uc003jgd.2_Missense_Mutation_p.T635I|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	635	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GCGCCTCAGGGTGATAAAAAG	0.423													0	0	0	0.007291	0	30	301										A	19473804	G	A	19473804	3	1	22	1	0	0	0	0	1	0	0	0	3103	1261	44	2	472	2	CDH18	5	19473804	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08		19473804	161441456	131	6328										
AMACR	23600	broad.mit.edu	37	chr5	33989503	33989503	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtcaaagatttgacaccactCtgccttcgtcttctctgcaa	6	13	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:33989503C>T	uc003jig.2	-	5	926	c.844G>A	c.(844-846)GAG>AAG	p.E282K	AMACR_uc003jih.2_3'UTR|AMACR_uc003jii.2_Missense_Mutation_p.E267K|AMACR_uc003jij.2_Missense_Mutation_p.E282K	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	282					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						TGACACCACTCTGCCTTCGTC	0.458													0	0	0	0.00361	0	63	83										T	33989503	C	T	33989503	3	4	22	1	0	0	0	0	1	0	0	0	562	922	32	1	366	1	AMACR	5	33989503	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	14515699	33989503	146925757	132	6329										
C5orf42	65250	broad.mit.edu	37	chr5	37169135	37169135	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttttataaacactgaagagtCctgttgaggtgtcaaatttt	8	5	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:37169135C>T	uc011cpa.1	-	34	7222	c.6991G>A	c.(6991-6993)GAC>AAC	p.D2331N	C5orf42_uc011coy.1_Missense_Mutation_p.D831N|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.D1406N|C5orf42_uc003jkr.1_Missense_Mutation_p.D364N	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2331										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACTGAAGAGTCCTGTTGAGGT	0.388													0	0	0	0.00361	0	55	96										T	37169135	C	T	37169135	3	4	22	1	0	0	0	0	1	0	0	0	2301	855	30	1	2678	1	C5orf42	5	37169135	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	3179632	37169135	143746125	133	6330										
PPAP2A	8611	broad.mit.edu	37	chr5	54737704	54737704	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caaacagcatgcagtacatgGaaaacgaagagtggcctgaa	11	8	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:54737704G>A	uc003jqa.2	-	4	940	c.524C>T	c.(523-525)TCC>TTC	p.S175F	PPAP2A_uc003jpz.2_Missense_Mutation_p.S176F|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	175	Helical; (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GCAGTACATGGAAAACGAAGA	0.403													0	0	0	0.001984	0	6	93										A	54737704	G	A	54737704	3	1	22	1	0	0	0	0	1	0	0	0	12290	1174	41	1	342	1	PPAP2A	5	54737704	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	17568569	54737704	126177556	134	6331										
CARTPT	9607	broad.mit.edu	37	chr5	71015207	71015207	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttgggtacccgtgcccaggaGgacgccgagctccagccccg	14	16	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:71015207G>A	uc003kbv.1	+	1	214	c.87G>A	c.(85-87)GAG>GAA	p.E29E		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	29					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	GTGCCCAGGAGGACGCCGAGC	0.662													0	0	0	0.001984	0	7	127										A	71015207	G	A	71015207	2	1	22	1	0	0	0	0	0	0	0	1	2659	991	35	2		2	CARTPT	5	71015207	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16277503	71015207	109900053	135	6332										
BTF3	689	broad.mit.edu	37	chr5	72798768	72798768	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtttacaaaccaaggaacaGtgatccactttaacaaccct	5	11	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:72798768G>A	uc003kcr.1	+	4	586	c.343G>A	c.(343-345)GTG>ATG	p.V115M	BTF3_uc003kcq.1_Missense_Mutation_p.V71M|BTF3_uc003kcs.1_RNA|BTF3_uc003kct.1_RNA	NM_001037637	NP_001032726	P20290	BTF3_HUMAN	basic transcription factor 3 isoform A	115	NAC-A/B.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding				0		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		CCAAGGAACAGTGATCCACTT	0.363													0	0	0	0.00361	0	63	98										A	72798768	G	A	72798768	3	1	22	1	0	0	0	0	1	0	0	0	1551	1029	36	2	357	2	BTF3	5	72798768	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1783561	72798768	108116492	136	6333										
HOMER1	9456	broad.mit.edu	37	chr5	78672000	78672000	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gacagttgtccctccaggtcTttgttccgaatttctacttc	7	12	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:78672000T>C	uc003kfy.2	-	9	2000	c.897A>G	c.(895-897)AAA>AAG	p.K299K	HOMER1_uc010jab.2_3'UTR|HOMER1_uc010jac.2_Silent_p.K169K|HOMER1_uc010jad.2_Silent_p.K125K	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	299	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		CCTCCAGGTCTTTGTTCCGAA	0.358													0	0	0	0.013114	0	44	58										C	78672000	T	C	78672000	2	2	22	1	0	0	0	0	0	0	0	1	7278	1606	56	5		5	HOMER1	5	78672000	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	5873232	78672000	102243260	137	6334										
RASGRF2	5924	broad.mit.edu	37	chr5	80409473	80409473	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gccaccactggctgtgtccaGaacatcttccccagtgaggg	11	14	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:80409473G>T	uc003kha.1	+	15	2204	c.2204G>T	c.(2203-2205)AGA>ATA	p.R735I	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	735	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		GCTGTGTCCAGAACATCTTCC	0.522													1	0	1.47197e-15	0.007835	1.6439e-15	41	67										T	80409473	G	T	80409473	3	4	22	1	0	0	0	0	1	0	0	0	13073	942	33	3	2262	3	RASGRF2	5	80409473	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1737473	80409473	100505787	138	6335										
SRFBP1	153443	broad.mit.edu	37	chr5	121330336	121330336	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctaaatctgctcttggtgatGatatcaactttgaaaaaatc	6	7	3	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:121330336G>A	uc003kst.1	+	4	313	c.241G>A	c.(241-243)GAT>AAT	p.D81N		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TCTTGGTGATGATATCAACTT	0.254													0	0	0	0.00245	0	14	12										A	121330336	G	A	121330336	3	1	22	1	0	0	0	0	1	0	0	0	15143	1290	45	1	255	1	SRFBP1	5	121330336	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	40920863	121330336	59584924	139	6336										
FBN2	2201	broad.mit.edu	37	chr5	127800489	127800489	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aggctgggctggacacatctCacagggatggccccacgccc	13	15	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:127800489C>G	uc003kuu.2	-	6	1193	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	FBN2_uc003kuv.2_Missense_Mutation_p.E219Q|FBN2_uc003kuw.3_Missense_Mutation_p.E252Q|FBN2_uc003kux.1_Missense_Mutation_p.E252Q	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	252	TB 1.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGACACATCTCACAGGGATGG	0.607													0	0	0	0.012213	0	34	121										G	127800489	C	G	127800489	3	3	22	1	0	0	0	0	1	0	0	0	5703	835	29	1	8224	1	FBN2	5	127800489	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6470153	127800489	53114771	140	6337										
DDX46	9879	broad.mit.edu	37	chr5	134102654	134102654	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aagccgagagcgaagaagatCtcgaagtagagacaggagac	14	7	1	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:134102654C>G	uc003kzw.2	+	3	422	c.254C>G	c.(253-255)TCT>TGT	p.S85C	DDX46_uc003kzv.1_Intron	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	85	Arg-rich.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGAAGAAGATCTCGAAGTAGA	0.473													0	0	0	0.006214	0	10	64										G	134102654	C	G	134102654	3	3	22	1	0	0	0	0	1	0	0	0	4364	913	32	1	264	1	DDX46	5	134102654	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6302165	134102654	46812606	141	6338										
PCDHA3	56145	broad.mit.edu	37	chr5	140180995	140180995	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgggtggcgtccaaaagacaCggggaccttctggaggtaaa	15	9	1	1	rs138112183		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140180995C>A	uc003lhf.2	+	1	213	c.213C>A	c.(211-213)CAC>CAA	p.H71Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.H71Q	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	71	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAAAGACACGGGGACCTTC	0.627													1	0	7.92265e-33	0.00361	9.1869e-33	58	346										A	140180995	C	A	140180995	3	1	22	1	0	0	0	0	1	0	0	0	11525	535	19	4	215	4	PCDHA3	5	140180995	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6078341	140180995	40734265	142	6339										
PCDHA12	56137	broad.mit.edu	37	chr5	140256931	140256931	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcacatcccgttccacgtggGgctgtacactggcgagatca	12	13	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140256931G>T	uc003lic.2	+	1	2001	c.1874G>T	c.(1873-1875)GGG>GTG	p.G625V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.G625V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	625	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCACGTGGGGCTGTACACT	0.677													1	0	6.4308e-24	0.00361	7.27134e-24	53	81										T	140256931	G	T	140256931	3	4	22	1	0	0	0	0	1	0	0	0	11522	1232	43	4	1876	4	PCDHA12	5	140256931	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	75936	140256931	40658329	143	6340										
PCDHB11	56125	broad.mit.edu	37	chr5	140579906	140579906	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttaaaatgagagtcattccaGacaataggaaataccccgag	8	8	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140579906G>C	uc003liy.2	+	1	559	c.559G>C	c.(559-561)GAC>CAC	p.D187H	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	187	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCATTCCAGACAATAGGAA	0.448													0	0	0	0.001855	0	13	96										C	140579906	G	C	140579906	3	2	22	1	0	0	0	0	1	0	0	0	11536	942	33	1	561	1	PCDHB11	5	140579906	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	322975	140579906	40335354	144	6341										
PCDHGA7	56108	broad.mit.edu	37	chr5	140763792	140763792	+	Frame_Shift_Del	DEL	G	G	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actcacatattcatgcaggtGgcagacaccaacgataaccc							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:140763792delG	uc003lka.1	+	1	1326	c.1326delG	c.(1324-1326)GTGfs	p.V442fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Frame_Shift_Del_p.V442fs	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	442	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATGCAGGTGGCAGACACCA	0.507																		13	116	---	---								-	140763792	G	-	140763792	7	5	22	1	0	1	0	1	0	0	0	0	11559	1335	47	0	1328	0	PCDHGA7	5	140763792	Frame_Shift_Del	DEL	G	TCGA-BT-A42C-01A-11D-A23M-08	183886	140763792	40151468	145	6342										
C5orf54	63920	broad.mit.edu	37	chr5	159822193	159822193	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaggattcttctccttggcaCataaatacgcaaattgatac	7	9	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr5:159822193C>T	uc003lye.1	-	2	769	c.305G>A	c.(304-306)TGT>TAT	p.C102Y	C5orf54_uc003lyf.1_Missense_Mutation_p.C102Y	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	102										pancreas(1)	1						ctccttggcacataaatacgc	0													0	0	0	0.00361	0	55	52										T	159822193	C	T	159822193	3	4	22	1	0	0	0	0	1	0	0	0	2310	478	17	2	1483	2	C5orf54	5	159822193	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	19058401	159822193	21093067	146	6343										
TXNDC5	81567	broad.mit.edu	37	chr6	7904949	7904949	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cggctgcagccgctggcagtGtccacacctggaacaaggca	13	14	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:7904949G>A	uc003mxv.2	-	2	303	c.271C>T	c.(271-273)CAC>TAC	p.H91Y	TXNDC5_uc003mxw.2_Missense_Mutation_p.H48Y|TXNDC5_uc010jnz.2_5'UTR|TXNDC5_uc010joa.1_5'UTR	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	91	Thioredoxin 1.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					CGCTGGCAGTGTCCACACCTG	0.547													0	0	0	0.00361	0	55	46										A	7904949	G	A	7904949	3	1	22	1	0	0	0	0	1	0	0	0	16796	1377	48	2	1063	2	TXNDC5	6	7904949	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08		7904949	163210118	147	6344										
DCDC2	51473	broad.mit.edu	37	chr6	24205258	24205258	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctggaacctcaacctgagtaTcttcatcttcttggacttct	6	12	6	1	rs150003705		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:24205258T>A	uc003ndx.2	-	8	1297	c.995A>T	c.(994-996)GAT>GTT	p.D332V	DCDC2_uc003ndy.2_Missense_Mutation_p.D332V|DCDC2_uc003ndw.2_Missense_Mutation_p.D83V	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	332					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				AACCTGAGTATCTTCATCTTC	0.403													0	0	0	0.00632	0	25	387										A	24205258	T	A	24205258	3	1	22	1	0	0	0	0	1	0	0	0	4285	1435	50	5	447	5	DCDC2	6	24205258	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	16300309	24205258	146909809	148	6345										
SLC17A3	10786	broad.mit.edu	37	chr6	25845738	25845738	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gacattcctccacccaaactCagggtcctggagacacaaaa	7	14	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:25845738C>T	uc003nfi.3	-	11	1245	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	SLC17A3_uc003nfk.3_Missense_Mutation_p.E457K	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	379					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						CACCCAAACTCAGGGTCCTGG	0.413													0	0	0	0.00361	0	73	44										T	25845738	C	T	25845738	3	4	22	1	0	0	0	0	1	0	0	0	14418	835	29	1	131	1	SLC17A3	6	25845738	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1640480	25845738	145269329	149	6346										
SLC17A2	10246	broad.mit.edu	37	chr6	25921506	25921506	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agaagggaagagatcagcaaAccagcaccaagcattttttt	9	8	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:25921506A>T	uc011dkb.1	-	3	458	c.375T>A	c.(373-375)GGT>GGA	p.G125G	SLC17A2_uc011dkc.1_Silent_p.G125G|SLC17A2_uc003nfl.2_Silent_p.G125G			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	125					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						AGATCAGCAAACCAGCACCAA	0.468													0	0	0	0.008871	0	19	129										T	25921506	A	T	25921506	2	4	22	1	0	0	0	0	0	0	0	1	14417	30	2	5		5	SLC17A2	6	25921506	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	75768	25921506	145193561	150	6347										
ZNF184	7738	broad.mit.edu	37	chr6	27425078	27425078	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttacctatagagaccaggtgTgtataattttccaatgtcac	7	8	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:27425078T>A	uc003njj.2	-	3	997	c.186A>T	c.(184-186)ACA>ACT	p.T62T	ZNF184_uc010jqv.2_Silent_p.T62T|ZNF184_uc003nji.2_Silent_p.T62T	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	62	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGACCAGGTGTGTATAATTTT	0.448													0	0	0	0.001368	0	12	134										A	27425078	T	A	27425078	2	1	22	1	0	0	0	0	0	0	0	1	17748	1683	59	5		5	ZNF184	6	27425078	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	1503572	27425078	143689989	151	6348										
OR2B2	81697	broad.mit.edu	37	chr6	27879892	27879892	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttgtggtatagcaaaggtccAggagtgagagattgctaaga	14	4	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:27879892A>T	uc011dkw.1	-	1	206	c.206T>A	c.(205-207)CTG>CAG	p.L69Q		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCAAAGGTCCAGGAGTGAGAG	0.413													0	0	0	0.005524	0	37	80										T	27879892	A	T	27879892	3	4	22	1	0	0	0	0	1	0	0	0	10989	188	7	5	871	5	OR2B2	6	27879892	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	454814	27879892	143235175	152	6349										
ZNF193	7746	broad.mit.edu	37	chr6	28200426	28200426	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cacatgggaaaatgtttaatGagcagacctgggaggtatca	12	6	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:28200426G>C	uc003nkq.1	+	4	770	c.655G>C	c.(655-657)GAG>CAG	p.E219Q	ZNF193_uc003nkr.1_Missense_Mutation_p.E219Q|ZNF193_uc010jqz.1_Missense_Mutation_p.E270Q	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	219					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATGTTTAATGAGCAGACCTG	0.458													0	0	0	0.001368	0	13	85										C	28200426	G	C	28200426	3	2	22	1	0	0	0	0	1	0	0	0	17754	1291	45	1	665	1	ZNF193	6	28200426	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	320534	28200426	142914641	153	6350										
PPP1R11	6992	broad.mit.edu	37	chr6	30035194	30035194	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctgagccttagccatggccGaggcaggggctgggctgagc	17	12	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:30035194G>T	uc003npb.2	+	1	263	c.7G>T	c.(7-9)GAG>TAG	p.E3*	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	3						soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3						AGCCATGGCCGAGGCAGGGGC	0.607													1	0	1.45844e-13	0.002836	1.62214e-13	31	171										T	30035194	G	T	30035194	4	4	22	1	0	0	0	0	0	1	0	0	12353	1059	37	3	9	3	PPP1R11	6	30035194	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1834768	30035194	141079873	154	6351										
KIAA1949	170954	broad.mit.edu	37	chr6	30652748	30652748	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggtttctgagtttgagcctCtatgtccctgggtgtccatt	11	9	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:30652748C>G	uc003nra.2	-	2	1279	c.1048G>C	c.(1048-1050)GAG>CAG	p.E350Q	KIAA1949_uc003nrb.3_Missense_Mutation_p.E350Q	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	350						cytoplasm|cytoskeleton	actin binding				0						GTTTGAGCCTCTATGTCCCTG	0.577													0	0	0	0.003163	0	16	295										G	30652748	C	G	30652748	3	3	22	1	0	0	0	0	1	0	0	0	8263	922	32	1	805	1	KIAA1949	6	30652748	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	617554	30652748	140462319	155	6352										
MDC1	9656	broad.mit.edu	37	chr6	30671304	30671305	+	Frame_Shift_Ins	INS	-	-	T													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tctcttgcctggttttggagINStcacgacatcctgagattga							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:30671304_30671305insT	uc003nrg.3	-	11	6012_6013	c.5572_5573insA	c.(5572-5574)ACTfs	p.T1858fs	MDC1_uc003nrf.3_Frame_Shift_Ins_p.T489fs	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1858	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TGGTTTTGGAGTCACGACATCC	0.505								Other_conserved_DNA_damage_response_genes										223	167	---	---								T	30671305	-	T	30671304	7	5	22	1	0	1	1	0	0	0	0	0	9403	1029	36	0	716	0	MDC1	6	30671304	Frame_Shift_Ins	INS	-	TCGA-BT-A42C-01A-11D-A23M-08	18556	30671304	140443763	156	6353										
CCHCR1	54535	broad.mit.edu	37	chr6	31110756	31110756	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agaccttttatggactccctGgtgggcactgctgctgctac	11	12	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:31110756G>C	uc003nsr.3	-	17	2331	c.2208C>G	c.(2206-2208)ACC>ACG	p.T736T	CCHCR1_uc011dne.1_Silent_p.T722T|CCHCR1_uc003nsq.3_Silent_p.T789T|CCHCR1_uc003nsp.3_Silent_p.T825T	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	736					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						TGGACTCCCTGGTGGGCACTG	0.532													0	0	0	0.00361	0	61	779										C	31110756	G	C	31110756	2	2	22	1	0	0	0	0	0	0	0	1	2877	1335	47	4		4	CCHCR1	6	31110756	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	439452	31110756	140004311	157	6354										
C6orf27	80737	broad.mit.edu	37	chr6	31733741	31733741	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcttctcgtccccctgcagtCacagtcaccatcaccacgga	7	18	4	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:31733741C>G	uc011dog.1	-	16	2656	c.2418G>C	c.(2416-2418)GTG>GTC	p.V806V		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	806						extracellular region				ovary(3)	3						CCCCTGCAGTCACAGTCACCA	0.637													0	0	0	0.00278	0	24	440										G	31733741	C	G	31733741	2	3	22	1	0	0	0	0	0	0	0	1	2362	813	29	1		1	C6orf27	6	31733741	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	622985	31733741	139381326	158	6355										
DAXX	1616	broad.mit.edu	37	chr6	33289243	33289243	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagaggatgttgcagaactcCgccgaggccaaaaacagaga	13	9	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:33289243C>T	uc003oec.2	-	3	513	c.309G>A	c.(307-309)GCG>GCA	p.A103A	DAXX_uc011drd.1_Silent_p.A28A|DAXX_uc011dre.1_Silent_p.A115A|DAXX_uc003oed.2_Silent_p.A103A|DAXX_uc010juw.2_Silent_p.A28A	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	103	Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding	p.A103fs*40(1)		pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TGCAGAACTCCGCCGAGGCCA	0.562			Mis|F|N		Pancreatic neuroendocrine tumors								0	0	0	0.008291	0	10	271										T	33289243	C	T	33289243	2	4	22	1	0	0	0	0	0	0	0	1	4243	639	23	2		2	DAXX	6	33289243	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1555502	33289243	137825824	159	6356										
LHFPL5	222662	broad.mit.edu	37	chr6	35773642	35773642	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcaggctacttcggccttttCtcctactgcgtgggtaacgt	11	12	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:35773642C>G	uc003olg.1	+	1	572	c.195C>G	c.(193-195)TTC>TTG	p.F65L		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	65	Helical; (Potential).					integral to membrane				skin(1)	1						TCGGCCTTTTCTCCTACTGCG	0.587													0	0	0	0.00361	0	311	165										G	35773642	C	G	35773642	3	3	22	1	0	0	0	0	1	0	0	0	8768	912	32	1	197	1	LHFPL5	6	35773642	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2484399	35773642	135341425	160	6357										
CDKN1A	1026	broad.mit.edu	37	chr6	36651884	36651885	+	Frame_Shift_Ins	INS	-	-	G													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgctgcaggcgccatgtcaINSgaaccggctggggatgtccg							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:36651884_36651885insG	uc003omm.3	+	2	128_129	c.6_7insG	c.(4-9)TCAGAAfs	p.S2fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.S36fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.S2fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.S2fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	2_3					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GCGCCATGTCAGAACCGGCTGG	0.629									Multiple_Endocrine_Neoplasia_type_1									18	18	---	---								G	36651885	-	G	36651884	7	5	22	1	0	1	1	0	0	0	0	0	3158	175	7	0	8	0	CDKN1A	6	36651884	Frame_Shift_Ins	INS	-	TCGA-BT-A42C-01A-11D-A23M-08	878242	36651884	134463183	161	6358										
KIF6	221458	broad.mit.edu	37	chr6	39545887	39545887	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgctccccagtgaccatggCcagttcatccttcagttcct	7	16	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:39545887C>A	uc003oot.2	-	10	1221	c.1126G>T	c.(1126-1128)GCC>TCC	p.A376S	KIF6_uc010jxa.1_Missense_Mutation_p.A167S|KIF6_uc011dua.1_Missense_Mutation_p.A376S|KIF6_uc010jxb.1_Missense_Mutation_p.A376S	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	376	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GTGACCATGGCCAGTTCATCC	0.428													1	0	2.4624e-09	0.008871	2.67865e-09	19	201										A	39545887	C	A	39545887	3	1	22	1	0	0	0	0	1	0	0	0	8308	739	26	4	1374	4	KIF6	6	39545887	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2894003	39545887	131569180	162	6359										
TREM2	54209	broad.mit.edu	37	chr6	41126740	41126740	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgctagaatcttgatgagaaAgatgcaggccaggaggagaa	14	5	1	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:41126740A>T	uc003opy.2	-	4	649	c.547T>A	c.(547-549)TTT>ATT	p.F183I	TREM2_uc003opz.2_Missense_Mutation_p.L226H|TREM2_uc010jxl.1_Intron	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	183	Helical; (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTGATGAGAAAGATGCAGGCC	0.567													0	0	0	0.008291	0	11	104										T	41126740	A	T	41126740	3	4	22	1	0	0	0	0	1	0	0	0	16468	72	3	5	153	5	TREM2	6	41126740	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	1580853	41126740	129988327	163	6360										
PRICKLE4	29964	broad.mit.edu	37	chr6	41754506	41754506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccggcccggaacaggggagaCtggactcgaccgaactgaag	15	12	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:41754506C>T	uc011duf.1	+	8	1042	c.794C>T	c.(793-795)ACT>ATT	p.T265I	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_RNA|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	225						nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACAGGGGAGACTGGACTCGAC	0.612													0	0	0	0.001855	0	14	193										T	41754506	C	T	41754506	3	4	22	1	0	0	0	0	1	0	0	0	12489	565	20	2	816	2	PRICKLE4	6	41754506	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	627766	41754506	129360561	164	6361										
HTR1B	3351	broad.mit.edu	37	chr6	78172393	78172393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcttgccggtcctgttgggcGtctgtttcaaaatccgggag	14	10	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:78172393G>A	uc003pil.1	-	1	728	c.728C>T	c.(727-729)ACG>ATG	p.T243M		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	243	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	CCTGTTGGGCGTCTGTTTCAA	0.612													0	0	0	0.00361	0	69	37										A	78172393	G	A	78172393	3	1	22	1	0	0	0	0	1	0	0	0	7437	1145	40	2	448	2	HTR1B	6	78172393	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	36417887	78172393	92942674	165	6362										
DSE	29940	broad.mit.edu	37	chr6	116757645	116757645	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tagggccatctatagatgttCagagcttcactgtccacgga	10	10	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:116757645C>T	uc003pws.2	+	6	2208	c.2014C>T	c.(2014-2016)CAG>TAG	p.Q672*	DSE_uc011ebg.1_Nonsense_Mutation_p.Q691*|DSE_uc003pwt.2_Nonsense_Mutation_p.Q672*|DSE_uc003pwu.2_Nonsense_Mutation_p.Q339*	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	672					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TATAGATGTTCAGAGCTTCAC	0.517													0	0	0	0.00361	0	55	127										T	116757645	C	T	116757645	4	4	22	1	0	0	0	0	0	1	0	0	4774	827	29	1	2032	1	DSE	6	116757645	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	38585252	116757645	54357422	166	6363										
VNN1	8876	broad.mit.edu	37	chr6	133014264	133014264	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caacagctgacaaatgtggcAaaacattcatccaagctgtt	7	10	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:133014264A>G	uc003qdo.2	-	4	745	c.725T>C	c.(724-726)TTG>TCG	p.L242S		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	242	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		CAAATGTGGCAAAACATTCAT	0.428													0	0	0	0.00361	0	50	34										G	133014264	A	G	133014264	3	3	22	1	0	0	0	0	1	0	0	0	17179	131	5	5	832	5	VNN1	6	133014264	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	16256619	133014264	38100803	167	6364										
STX11	8676	broad.mit.edu	37	chr6	144508445	144508445	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atccgcgacgtacacgagctCttcttgcagatggcggtgct	12	12	2	1	rs145774130	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:144508445C>G	uc003qks.3	+	2	873	c.681C>G	c.(679-681)CTC>CTG	p.L227L		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	227	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TACACGAGCTCTTCTTGCAGA	0.652									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.006999	0	41	25										G	144508445	C	G	144508445	2	3	22	1	0	0	0	0	0	0	0	1	15336	900	32	1		1	STX11	6	144508445	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	11494181	144508445	26606622	168	6365										
IYD	389434	broad.mit.edu	37	chr6	150713540	150713540	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcgtggttgtgaaggacccaGacgtgaagcacaagattcga	13	8	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:150713540G>C	uc003qnu.1	+	3	570	c.430G>C	c.(430-432)GAC>CAC	p.D144H	IYD_uc003qnv.1_Missense_Mutation_p.D144H|IYD_uc003qnw.1_RNA|IYD_uc003qnx.1_Missense_Mutation_p.D144H|IYD_uc010kik.1_Missense_Mutation_p.D62H	NM_203395	NP_981932	Q6PHW0	IYD1_HUMAN	iodotyrosine dehalogenase 1 isoform 2	144	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				ovary(2)	2		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		GAAGGACCCAGACGTGAAGCA	0.493													0	0	0	0.012319	0	23	196										C	150713540	G	C	150713540	3	2	22	1	0	0	0	0	1	0	0	0	7932	942	33	1	440	1	IYD	6	150713540	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6205095	150713540	20401527	169	6366										
TIAM2	26230	broad.mit.edu	37	chr6	155451184	155451184	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccccggcatgcctgaccccaGtctccatgccagcttcccac	7	21	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr6:155451184G>T	uc003qqb.2	+	6	2100	c.827G>T	c.(826-828)AGT>ATT	p.S276I	TIAM2_uc003qqe.2_Missense_Mutation_p.S276I	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	276					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCTGACCCCAGTCTCCATGCC	0.602													1	0	9.4991e-31	0.00361	1.09451e-30	68	31										T	155451184	G	T	155451184	3	4	22	1	0	0	0	0	1	0	0	0	15888	1029	36	4	829	4	TIAM2	6	155451184	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4737644	155451184	15663883	170	6367										
CARD11	84433	broad.mit.edu	37	chr7	2978460	2978460	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagtctggcaggctgcgcttCccggcctgggtgggagggag	20	10	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:2978460C>T	uc003smv.2	-	7	1274	c.870G>A	c.(868-870)GGG>GGA	p.G290G		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	290	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGCTGCGCTTCCCGGCCTGGG	0.632			Mis		DLBCL								0	0	0	0.00308	0	7	65										T	2978460	C	T	2978460	2	4	22	1	0	0	0	0	0	0	0	1	2645	842	30	1		1	CARD11	7	2978460	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		2978460	156160203	171	6368										
GLI3	2737	broad.mit.edu	37	chr7	42005113	42005113	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aacccaaaggcgcgagtctgCggcacagcgggccgcggccc	15	16	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:42005113C>A	uc011kbh.1	-	15	3649	c.3558G>T	c.(3556-3558)CCG>CCT	p.P1186P	GLI3_uc011kbg.1_Silent_p.P1127P	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1186					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGCGAGTCTGCGGCACAGCGG	0.652									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				1	0	3.61922e-38	0.00361	4.20571e-38	92	179										A	42005113	C	A	42005113	2	1	22	1	0	0	0	0	0	0	0	1	6439	755	27	4		4	GLI3	7	42005113	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	39026653	42005113	117133550	172	6369										
GLI3	2737	broad.mit.edu	37	chr7	42005561	42005561	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gactgcgcttctccgcggacGtggccatcgccggggggttg	17	13	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:42005561G>A	uc011kbh.1	-	15	3201	c.3110C>T	c.(3109-3111)ACG>ATG	p.T1037M	GLI3_uc011kbg.1_Missense_Mutation_p.T978M	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1037					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTCCGCGGACGTGGCCATCGC	0.697									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.007413	0	17	60										A	42005561	G	A	42005561	3	1	22	1	0	0	0	0	1	0	0	0	6439	1145	40	2	1636	2	GLI3	7	42005561	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	448	42005561	117133102	173	6370										
OGDH	4967	broad.mit.edu	37	chr7	44736090	44736090	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctccacgggtctgacggagGatattctgacacacatcggg	12	12	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:44736090G>T	uc003tln.2	+	14	1943	c.1834G>T	c.(1834-1836)GAT>TAT	p.D612Y	OGDH_uc011kbx.1_Missense_Mutation_p.D608Y|OGDH_uc011kby.1_Missense_Mutation_p.D462Y|OGDH_uc003tlp.2_Missense_Mutation_p.D623Y|OGDH_uc011kbz.1_Missense_Mutation_p.D407Y|OGDH_uc003tlo.1_Missense_Mutation_p.D445Y	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	612					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCTGACGGAGGATATTCTGAC	0.527													1	0	1.96292e-10	0.010504	2.1525e-10	21	102										T	44736090	G	T	44736090	3	4	22	1	0	0	0	0	1	0	0	0	10839	1174	41	3	2057	3	OGDH	7	44736090	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2730529	44736090	114402573	174	6371										
OGDH	4967	broad.mit.edu	37	chr7	44737336	44737336	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggacaagccaagtgggtgcgGcagaatggcatcgtgttgct	16	8	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:44737336G>C	uc003tln.2	+	17	2422	c.2313G>C	c.(2311-2313)CGG>CGC	p.R771R	OGDH_uc011kbx.1_Silent_p.R767R|OGDH_uc011kby.1_Silent_p.R621R|OGDH_uc003tlp.2_Silent_p.R782R|OGDH_uc011kbz.1_Silent_p.R566R	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	771					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	AGTGGGTGCGGCAGAATGGCA	0.602													0	0	0	0.004482	0	7	148										C	44737336	G	C	44737336	2	2	22	1	0	0	0	0	0	0	0	1	10839	1190	42	4		4	OGDH	7	44737336	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1246	44737336	114401327	175	6372										
GTF2I	2969	broad.mit.edu	37	chr7	74105441	74105469	+	Splice_Site	DEL	ATTGTAAGCATTGTATTTTTATCTTTTGC	ATTGTAAGCATTGTATTTTTATCTTTTGC	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcaaaaagattttgtaaaatAttgtaagcattgtattttta							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:74105441_74105469delATTGTAAGCATTGTATTTTTATCTTTTGC	uc003uau.2	+	3	608	c.238_splice	c.e3+1	p.C80_splice	GTF2I_uc003uat.2_Splice_Site_p.C80_splice|GTF2I_uc003uav.2_Splice_Site_p.C80_splice|GTF2I_uc003uaw.2_Splice_Site_p.C80_splice|GTF2I_uc003uay.2_Splice_Site_p.C80_splice|GTF2I_uc003uax.2_Splice_Site_p.C80_splice	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TTTGTAAAATATTGTAAGCATTGTATTTTTATCTTTTGCATTTCATTAA	0.24																		8	98	---	---								-	74105469	ATTGTAAGCATTGTATTTTTATCTTTTGC	-	74105441	8	5	22	1	0	1	0	1	0	0	1	0	6867	449	16	0	242	0	GTF2I	7	74105441	Splice_Site	DEL	ATTGTAAGCATTGTATTTTTATCTTTTGC	TCGA-BT-A42C-01A-11D-A23M-08	29368105	74105441	85033222	176	6373										
CACNA2D1	781	broad.mit.edu	37	chr7	81746455	81746455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caatgaaaacaggttttatcCtctggctgcctggctcactg	9	11	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:81746455C>T	uc003uhr.1	-	6	687	c.431G>A	c.(430-432)AGG>AAG	p.R144K		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	144	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AGGTTTTATCCTCTGGCTGCC	0.358													0	0	0	0.006214	0	10	46										T	81746455	C	T	81746455	3	4	22	1	0	0	0	0	1	0	0	0	2548	681	24	2	2980	2	CACNA2D1	7	81746455	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	7641014	81746455	77392208	177	6374										
PCLO	27445	broad.mit.edu	37	chr7	82595105	82595105	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actgttttttctttcccaggTtccacctgatcaggttttgc	7	11	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:82595105T>A	uc003uhx.2	-	4	4288	c.3999A>T	c.(3997-3999)GAA>GAT	p.E1333D	PCLO_uc003uhv.2_Missense_Mutation_p.E1333D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTTCCCAGGTTCCACCTGAT	0.373													0	0	0	0.004289	0	32	81										A	82595105	T	A	82595105	3	1	22	1	0	0	0	0	1	0	0	0	11583	1722	60	5	11534	5	PCLO	7	82595105	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	848650	82595105	76543558	178	6375										
GRM3	2913	broad.mit.edu	37	chr7	86416022	86416022	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggccagcgacggctggggcgCgcaggagagcatcatcaagg	18	11	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:86416022C>T	uc003uid.2	+	3	2013	c.914C>T	c.(913-915)GCG>GTG	p.A305V	GRM3_uc010lef.2_Missense_Mutation_p.A303V|GRM3_uc010leg.2_Missense_Mutation_p.A177V|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	305	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GGCTGGGGCGCGCAGGAGAGC	0.677													0	0	0	0.003163	0	15	83										T	86416022	C	T	86416022	3	4	22	1	0	0	0	0	1	0	0	0	6798	768	27	2	920	2	GRM3	7	86416022	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	3820917	86416022	72722641	179	6376										
GAL3ST4	79690	broad.mit.edu	37	chr7	99758066	99758066	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tagaccccagcacagggcatCtgccagcagaaccaatgact	9	14	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:99758066C>T	uc003utt.2	-	3	1963	c.946G>A	c.(946-948)GAT>AAT	p.D316N	C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_Missense_Mutation_p.D316N|GAL3ST4_uc010lgq.2_Missense_Mutation_p.D254N	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	316	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACAGGGCATCTGCCAGCAGA	0.557													0	0	0	0.00361	0	47	147										T	99758066	C	T	99758066	3	4	22	1	0	0	0	0	1	0	0	0	6200	913	32	1	518	1	GAL3ST4	7	99758066	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	13342044	99758066	59380597	180	6377										
TRIP6	7205	broad.mit.edu	37	chr7	100469281	100469281	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtggtgtgtcaccgcggcctCgacggcatccccttcacagt	12	15	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:100469281C>T	uc003uww.2	+	7	1286	c.1116C>T	c.(1114-1116)CTC>CTT	p.L372L		NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	372	LIM zinc-binding 2.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					ACCGCGGCCTCGACGGCATCC	0.622													0	0	0	0.00623	0	35	49										T	100469281	C	T	100469281	2	4	22	1	0	0	0	0	0	0	0	1	16556	871	31	1		1	TRIP6	7	100469281	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	711215	100469281	58669382	181	6378										
MUC17	140453	broad.mit.edu	37	chr7	100682960	100682960	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atggaagtactccattaacaAgtatacttgtcagcaccctg	7	10	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:100682960A>T	uc003uxp.1	+	3	8316	c.8263A>T	c.(8263-8265)AGT>TGT	p.S2755C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2755	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|44.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCATTAACAAGTATACTTGT	0.493													0	0	0	0.012319	0	22	650										T	100682960	A	T	100682960	3	4	22	1	0	0	0	0	1	0	0	0	9974	72	3	5	8273	5	MUC17	7	100682960	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	213679	100682960	58455703	182	6379										
MUC17	140453	broad.mit.edu	37	chr7	100693838	100693838	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagaatacaagacagtattgGacaatgccaccgaagtagtg	10	8	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:100693838G>A	uc003uxp.1	+	7	12849	c.12796G>A	c.(12796-12798)GAC>AAC	p.D4266N	MUC17_uc010lho.1_Intron	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4266	Extracellular (Potential).|SEA.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GACAGTATTGGACAATGCCAC	0.463													0	0	0	0.004656	0	27	80										A	100693838	G	A	100693838	3	1	22	1	0	0	0	0	1	0	0	0	9974	1174	41	1	12822	1	MUC17	7	100693838	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10878	100693838	58444825	183	6380										
RELN	5649	broad.mit.edu	37	chr7	103197585	103197585	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggagaattgtaacagaataGagtgagatctctctggggta	13	4	2	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:103197585G>C	uc003vca.2	-	38	5796	c.5636C>G	c.(5635-5637)TCT>TGT	p.S1879C	RELN_uc010liz.2_Missense_Mutation_p.S1879C	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1879					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAACAGAATAGAGTGAGATCT	0.378													0	0	0	0.001168	0	6	53										C	103197585	G	C	103197585	3	2	22	1	0	0	0	0	1	0	0	0	13220	942	33	1	4858	1	RELN	7	103197585	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2503747	103197585	55941078	184	6381										
PLXNA4	91584	broad.mit.edu	37	chr7	131825479	131825493	+	In_Frame_Del	DEL	CAGAGAGGCAGGCGT	CAGAGAGGCAGGCGT	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catgaaggtctgagccaccaCagagaggcaggcgtctgtga							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:131825479_131825493delCAGAGAGGCAGGCGT	uc003vra.3	-	30	5532_5546	c.5303_5317delACGCCTGCCTCTCTG	c.(5302-5319)GACGCCTGCCTCTCTGTG>GTG	p.DACLS1768del	PLXNA4_uc003vqz.3_In_Frame_Del_p.DACLS53del	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1768_1772	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGAGCCACCACAGAGAGGCAGGCGTCTGTGATGCT	0.558																		15	195	---	---								-	131825493	CAGAGAGGCAGGCGT	-	131825479	7	5	22	1	0	1	0	1	0	0	0	0	12122	478	17	0	379	0	PLXNA4	7	131825479	In_Frame_Del	DEL	CAGAGAGGCAGGCGT	TCGA-BT-A42C-01A-11D-A23M-08	28627894	131825479	27313184	185	6382										
ZC3HAV1	56829	broad.mit.edu	37	chr7	138764694	138764694	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcctcttgactgccgttctcTaaaaacctctggcttgtccc	6	15	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:138764694T>C	uc003vun.2	-	4	1381	c.993A>G	c.(991-993)TTA>TTG	p.L331L	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Silent_p.L331L	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	331					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						TGCCGTTCTCTAAAAACCTCT	0.552													0	0	0	0.00361	0	63	70										C	138764694	T	C	138764694	2	2	22	1	0	0	0	0	0	0	0	1	17572	1519	53	5		5	ZC3HAV1	7	138764694	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	6939215	138764694	20373969	186	6383										
TAS2R39	259285	broad.mit.edu	37	chr7	142880649	142880649	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gttttacttgctgaatacctCattggtatcattgcaaatgg	8	7	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr7:142880649C>A	uc011ksw.1	+	1	138	c.138C>A	c.(136-138)CTC>CTA	p.L46L		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	46	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					CTGAATACCTCATTGGTATCA	0.413													1	0	0.00307968	0.00308	0.00315493	7	53										A	142880649	C	A	142880649	2	1	22	1	0	0	0	0	0	0	0	1	15573	813	29	3		3	TAS2R39	7	142880649	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4115955	142880649	16258014	187	6384										
MFHAS1	9258	broad.mit.edu	37	chr8	8748771	8748771	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcgccgtcgaaggttcttgtCcgaaacgccatagtaggctg	13	11	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:8748771C>G	uc003wsj.1	-	1	2361	c.1798G>C	c.(1798-1800)GAC>CAC	p.D600H		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	600	Roc.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		AGGTTCTTGTCCGAAACGCCA	0.642													0	0	0	0.001984	0	7	104										G	8748771	C	G	8748771	3	3	22	1	0	0	0	0	1	0	0	0	9521	855	30	1	1372	1	MFHAS1	8	8748771	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		8748771	137615251	188	6385										
DLC1	10395	broad.mit.edu	37	chr8	12957634	12957634	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gctgctgctgctggtctgcgTggagttggaaacgctcctct	14	11	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:12957634T>A	uc003wwm.2	-	9	2656	c.2212A>T	c.(2212-2214)ACG>TCG	p.T738S	DLC1_uc003wwk.1_Missense_Mutation_p.T301S|DLC1_uc003wwl.1_Missense_Mutation_p.T335S|DLC1_uc011kxx.1_Missense_Mutation_p.T227S	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	738					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CTGGTCTGCGTGGAGTTGGAA	0.617													0	0	0	0.003954	0	25	81										A	12957634	T	A	12957634	3	1	22	1	0	0	0	0	1	0	0	0	4550	1696	59	5	2414	5	DLC1	8	12957634	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	4208863	12957634	133406388	189	6386										
DLC1	10395	broad.mit.edu	37	chr8	12958064	12958064	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccagtgctgctgaggctgcgGacggaagacacctcctggcg	15	13	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:12958064G>A	uc003wwm.2	-	9	2226	c.1782C>T	c.(1780-1782)GTC>GTT	p.V594V	DLC1_uc003wwk.1_Silent_p.V157V|DLC1_uc003wwl.1_Silent_p.V191V|DLC1_uc011kxx.1_Silent_p.V83V	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	594					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TGAGGCTGCGGACGGAAGACA	0.697													0	0	0	0.00499	0	17	118										A	12958064	G	A	12958064	2	1	22	1	0	0	0	0	0	0	0	1	4550	1161	41	1		1	DLC1	8	12958064	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	430	12958064	133405958	190	6387										
MTUS1	57509	broad.mit.edu	37	chr8	17611869	17611869	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttggggtattcgttttgattGttgattttcctaaactgggt	11	4	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:17611869G>C	uc003wxv.2	-	2	1922	c.1448C>G	c.(1447-1449)ACA>AGA	p.T483R	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.T483R|MTUS1_uc010lsz.2_Missense_Mutation_p.T483R	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	483						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		CGTTTTGATTGTTGATTTTCC	0.378													0	0	0	0.00361	0	75	143										C	17611869	G	C	17611869	3	2	22	1	0	0	0	0	1	0	0	0	9965	1377	48	4	2739	4	MTUS1	8	17611869	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4653805	17611869	128752153	191	6388										
UNC5D	137970	broad.mit.edu	37	chr8	35579728	35579728	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atttctcttgtgtctttcagGcattgagaatgccagcgaca	9	9	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:35579728G>T	uc003xjr.1	+	9	1446	c.1118G>T	c.(1117-1119)AGC>ATC	p.S373I	UNC5D_uc003xjs.1_Missense_Mutation_p.S368I|UNC5D_uc003xju.1_5'Flank|UNC5D_uc003xjt.1_Missense_Mutation_p.G131V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	373	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TGTCTTTCAGGCATTGAGAAT	0.493													1	0	1.06961e-07	0.00308	1.12754e-07	8	182										T	35579728	G	T	35579728	3	4	22	1	0	0	0	0	1	0	0	0	16992	1217	42	4	1152	4	UNC5D	8	35579728	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	17967859	35579728	110784294	192	6389										
RAB11FIP1	80223	broad.mit.edu	37	chr8	37730513	37730513	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggatgtggaaatgggagctgCtatgggagatgagagagagg	20	2	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:37730513C>T	uc003xkm.1	-	4	1851	c.1807G>A	c.(1807-1809)GCA>ACA	p.A603T	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_5'UTR|RAB11FIP1_uc003xko.1_5'UTR|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	603	Ser-rich.				protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			ATGGGAGCTGCTATGGGAGAT	0.547													0	0	0	0.002836	0	34	111										T	37730513	C	T	37730513	3	4	22	1	0	0	0	0	1	0	0	0	12893	797	28	2	2056	2	RAB11FIP1	8	37730513	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2150785	37730513	108633509	193	6390										
FNTA	2339	broad.mit.edu	37	chr8	42911569	42911570	+	Frame_Shift_Ins	INS	-	-	C													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caacccccgccccagccgcaINScccaccgccgccccagcagc							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:42911569_42911570insC	uc003xps.2	+	1	128_129	c.80_81insC	c.(79-81)CACfs	p.H27fs	FNTA_uc003xpt.2_5'UTR|FNTA_uc003xpu.2_Frame_Shift_Ins_p.H27fs|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	27	Pro-rich.				cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CCCCAGCCGCACCCACCGCCGC	0.748																		5	4	---	---								C	42911570	-	C	42911569	7	5	22	1	0	1	1	0	0	0	0	0	5977	159	6	0	82	0	FNTA	8	42911569	Frame_Shift_Ins	INS	-	TCGA-BT-A42C-01A-11D-A23M-08	5181056	42911569	103452453	194	6391										
RGS22	26166	broad.mit.edu	37	chr8	101075735	101075735	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcccaatgtaccttttataaAtttcttaaatctttcaaact	1	9	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:101075735A>G	uc003yjb.1	-	8	1456	c.1261T>C	c.(1261-1263)TTT>CTT	p.F421L	RGS22_uc003yja.1_Missense_Mutation_p.F240L|RGS22_uc003yjc.1_Missense_Mutation_p.F409L|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	421					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CCTTTTATAAATTTCTTAAAT	0.388													0	0	0	0.006122	0	15	68										G	101075735	A	G	101075735	3	3	22	1	0	0	0	0	1	0	0	0	13305	101	4	5	2613	5	RGS22	8	101075735	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	58164166	101075735	45288287	195	6392										
PKHD1L1	93035	broad.mit.edu	37	chr8	110489537	110489537	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aagacgttgttattaatttcCaagcttactgttgtattctc	6	7	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:110489537C>T	uc003yne.2	+	53	9105	c.9001C>T	c.(9001-9003)CAA>TAA	p.Q3001*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3001	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TATTAATTTCCAAGCTTACTG	0.418										HNSCC(38;0.096)			0	0	0	0.012213	0	34	45										T	110489537	C	T	110489537	4	4	22	1	0	0	0	0	0	1	0	0	11972	595	21	2	9211	2	PKHD1L1	8	110489537	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	9413802	110489537	35874485	196	6393										
GSDMD	79792	broad.mit.edu	37	chr8	144643221	144643221	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaagacggtcaccatcccctCaggcagcaccctcgcattcc	8	18	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr8:144643221C>T	uc010mfe.2	+	8	1332	c.629C>T	c.(628-630)TCA>TTA	p.S210L	uc003yye.2_5'Flank|GSDMD_uc003yyf.2_Missense_Mutation_p.S258L|GSDMD_uc003yyi.2_3'UTR|GSDMD_uc003yyg.2_Missense_Mutation_p.S210L|GSDMD_uc003yyh.2_Missense_Mutation_p.S141L	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	210											0						ACCATCCCCTCAGGCAGCACC	0.667													0	0	0	0.001168	0	6	50										T	144643221	C	T	144643221	3	4	22	1	0	0	0	0	1	0	0	0	6819	838	29	1	643	1	GSDMD	8	144643221	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	34153684	144643221	1720801	197	6394										
TTC39B	158219	broad.mit.edu	37	chr9	15187022	15187022	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaaattgctgctttcaagaaCacataagttgccttgagaaa	7	7	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:15187022C>T	uc003zlr.1	-	15	1330	c.1209G>A	c.(1207-1209)GTG>GTA	p.V403V	TTC39B_uc003zlq.1_Silent_p.V372V|TTC39B_uc011lmp.1_Silent_p.V304V|TTC39B_uc010mie.1_Silent_p.V401V|TTC39B_uc011lmq.1_Silent_p.V390V|TTC39B_uc011lmr.1_Silent_p.V334V|TTC39B_uc010mif.1_Silent_p.V403V|TTC39B_uc003zlp.1_5'UTR	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	403							binding			ovary(1)	1						CTTTCAAGAACACATAAGTTG	0.383													0	0	0	0.007835	0	39	39										T	15187022	C	T	15187022	2	4	22	1	0	0	0	0	0	0	0	1	16705	465	17	2		2	TTC39B	9	15187022	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		15187022	126026409	198	6395										
DMRTA1	63951	broad.mit.edu	37	chr9	22451128	22451128	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aactgatctccaaatcccatCagctttacctaggatcatct	4	13	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:22451128C>T	uc003zpp.1	+	2	958	c.733C>T	c.(733-735)CAG>TAG	p.Q245*		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	245					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|skin(1)	2		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CAAATCCCATCAGCTTTACCT	0.398													0	0	0	0.003163	0	15	17										T	22451128	C	T	22451128	4	4	22	1	0	0	0	0	0	1	0	0	4588	827	29	1	739	1	DMRTA1	9	22451128	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	7264106	22451128	118762303	199	6396										
STOML2	30968	broad.mit.edu	37	chr9	35102793	35102793	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccagaggaggcgcggcgcgGagcgcggccagaagccagta	18	12	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:35102793G>C	uc003zwi.2	-	2	136	c.73C>G	c.(73-75)CCG>GCG	p.P25A	STOML2_uc003zwh.2_5'UTR|STOML2_uc003zwj.2_5'UTR|STOML2_uc011lou.1_Missense_Mutation_p.P25A|STOML2_uc003zwk.2_5'UTR	NM_013442	NP_038470	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	25						cytoskeleton	receptor binding				0			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCGCGGCGCGGAGCGCGGCCA	0.647													0	0	0	0.003271	0	34	77										C	35102793	G	C	35102793	3	2	22	1	0	0	0	0	1	0	0	0	15313	1174	41	1	1033	1	STOML2	9	35102793	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	12651665	35102793	106110638	200	6397										
EPB41L4B	54566	broad.mit.edu	37	chr9	111970252	111970252	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aactgggctttcagaatgttAcacttcacatgatccgcaac	7	11	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:111970252A>G	uc004bdz.1	-	18	2125	c.1830T>C	c.(1828-1830)TGT>TGC	p.C610C		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	610						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TCAGAATGTTACACTTCACAT	0.428													0	0	0	0.008871	0	19	119										G	111970252	A	G	111970252	2	3	22	1	0	0	0	0	0	0	0	1	5156	389	14	5		5	EPB41L4B	9	111970252	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	76867459	111970252	29243179	201	6398										
HSDL2	84263	broad.mit.edu	37	chr9	115216316	115216316	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgttccagaattcaaagaaGagaaactgcagctgcaacca	8	10	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:115216316G>C	uc004bga.1	+	9	982	c.889G>C	c.(889-891)GAG>CAG	p.E297Q	HSDL2_uc011lwv.1_Missense_Mutation_p.E176Q|HSDL2_uc004bgb.1_Missense_Mutation_p.E131Q|HSDL2_uc004bgc.1_Missense_Mutation_p.E224Q|HSDL2_uc011lww.1_Missense_Mutation_p.E92Q	NM_032303	NP_115679	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	297						peroxisome	oxidoreductase activity|sterol binding				0						ATTCAAAGAAGAGAAACTGCA	0.403													0	0	0	0.006214	0	9	49										C	115216316	G	C	115216316	3	2	22	1	0	0	0	0	1	0	0	0	7394	943	33	1	923	1	HSDL2	9	115216316	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3246064	115216316	25997115	202	6399										
CRB2	286204	broad.mit.edu	37	chr9	126128573	126128573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agcgggaggtgctggagtgcGcatcggcgccctgcgagcac	18	12	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:126128573G>A	uc004bnx.1	+	4	774	c.682G>A	c.(682-684)GCA>ACA	p.A228T	CRB2_uc004bnw.1_Missense_Mutation_p.A228T	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	228	Extracellular (Potential).|EGF-like 5.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GCTGGAGTGCGCATCGGCGCC	0.741													0	0	0	0.001168	0	5	3										A	126128573	G	A	126128573	3	1	22	1	0	0	0	0	1	0	0	0	3849	1087	38	2	696	2	CRB2	9	126128573	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10912257	126128573	15084858	203	6400										
SPTAN1	6709	broad.mit.edu	37	chr9	131356499	131356499	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagaagcgtaaaggcatgttGgagaagagttgcaagaagtt	15	3	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131356499G>A	uc004bvl.3	+	24	3374	c.3261G>A	c.(3259-3261)TTG>TTA	p.L1087L	SPTAN1_uc011mbg.1_Silent_p.L1067L|SPTAN1_uc011mbh.1_Silent_p.L1099L|SPTAN1_uc004bvm.3_Silent_p.L1087L|SPTAN1_uc004bvn.3_Silent_p.L1067L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1087	Spectrin 11.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AAGGCATGTTGGAGAAGAGTT	0.468													0	0	0	0.010771	0	43	36										A	131356499	G	A	131356499	2	1	22	1	0	0	0	0	0	0	0	1	15116	1339	47	2		2	SPTAN1	9	131356499	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5227926	131356499	9856932	204	6401										
SPTAN1	6709	broad.mit.edu	37	chr9	131356542	131356542	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgttgttccgtgaagcgaatGaactacagcaatggatcaat	10	7	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131356542G>T	uc004bvl.3	+	24	3417	c.3304G>T	c.(3304-3306)GAA>TAA	p.E1102*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.E1082*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.E1114*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.E1102*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.E1082*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1102	Spectrin 12.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAGCGAATGAACTACAGCA	0.468													1	0	1.19451e-25	0.00361	1.3648e-25	48	38										T	131356542	G	T	131356542	4	4	22	1	0	0	0	0	0	1	0	0	15116	1291	45	3	3394	3	SPTAN1	9	131356542	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	43	131356542	9856889	205	6402										
SPTAN1	6709	broad.mit.edu	37	chr9	131362362	131362362	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctctttctttgaataggatGaaactgattccaagacagcc	7	10	2	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131362362G>A	uc004bvl.3	+	27	3660	c.3547G>A	c.(3547-3549)GAA>AAA	p.E1183K	SPTAN1_uc011mbh.1_Missense_Mutation_p.E1195K|SPTAN1_uc004bvm.3_Missense_Mutation_p.E1183K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1163K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1183					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAATAGGATGAAACTGATTC	0.438													0	0	0	0.003755	0	34	20										A	131362362	G	A	131362362	3	1	22	1	0	0	0	0	1	0	0	0	15116	1291	45	1	3649	1	SPTAN1	9	131362362	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5820	131362362	9851069	206	6403										
SPTAN1	6709	broad.mit.edu	37	chr9	131367332	131367332	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagatgctgatgaaaccaaaGaatggattgaagagaagaat	12	3	0	7			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131367332G>C	uc004bvl.3	+	30	3852	c.3739G>C	c.(3739-3741)GAA>CAA	p.E1247Q	SPTAN1_uc011mbh.1_Missense_Mutation_p.E1259Q|SPTAN1_uc004bvm.3_Missense_Mutation_p.E1247Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1227Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1247	Spectrin 14.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAACCAAAGAATGGATTGA	0.413													0	0	0	0.005524	0	37	25										C	131367332	G	C	131367332	3	2	22	1	0	0	0	0	1	0	0	0	15116	943	33	1	3853	1	SPTAN1	9	131367332	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4970	131367332	9846099	207	6404										
SPTAN1	6709	broad.mit.edu	37	chr9	131378100	131378100	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agttcttccgggacatggatGacgaggagtcctggatcaag	14	8	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131378100G>A	uc004bvl.3	+	40	5436	c.5323G>A	c.(5323-5325)GAC>AAC	p.D1775N	SPTAN1_uc004bvm.3_Missense_Mutation_p.D1780N|SPTAN1_uc004bvn.3_Missense_Mutation_p.D1755N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1775	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGACATGGATGACGAGGAGTC	0.567													0	0	0	0.010771	0	44	25										A	131378100	G	A	131378100	3	1	22	1	0	0	0	0	1	0	0	0	15116	1290	45	1	5496	1	SPTAN1	9	131378100	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10768	131378100	9835331	208	6405										
SPTAN1	6709	broad.mit.edu	37	chr9	131394948	131394948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgcccatggtggaggaagggGaacctgaccctgagttcgag	16	9	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131394948G>A	uc004bvl.3	+	54	7209	c.7096G>A	c.(7096-7098)GAA>AAA	p.E2366K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E2371K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E2346K|SPTAN1_uc004bvo.3_Missense_Mutation_p.E133K|SPTAN1_uc004bvp.3_Missense_Mutation_p.E109K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2366	EF-hand 2.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGAGGAAGGGGAACCTGACCC	0.567													0	0	0	0.00361	0	58	35										A	131394948	G	A	131394948	3	1	22	1	0	0	0	0	1	0	0	0	15116	1175	41	1	7325	1	SPTAN1	9	131394948	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16848	131394948	9818483	209	6406										
WDR34	89891	broad.mit.edu	37	chr9	131397156	131397156	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agcctagggtcaaagctggaGaaggccactgccgtggcgcc	15	12	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:131397156G>A	uc004bvq.1	-	7	1150	c.1026C>T	c.(1024-1026)TTC>TTT	p.F342F	WDR34_uc004bvs.1_Silent_p.F333F|WDR34_uc004bvr.1_Silent_p.F314F	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	342						cytoplasm				central_nervous_system(2)|skin(1)	3						CAAAGCTGGAGAAGGCCACTG	0.647											OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	26	14										A	131397156	G	A	131397156	2	1	22	1	0	0	0	0	0	0	0	1	17285	933	33	1		1	WDR34	9	131397156	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2208	131397156	9816275	210	6407										
TSC1	7248	broad.mit.edu	37	chr9	135802666	135802666	+	Frame_Shift_Del	DEL	G	G	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccaggtaataatccaccaaGgtgtttacaagcatagggcc							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:135802666delG	uc004cca.2	-	4	366	c.132delC	c.(130-132)ACCfs	p.T44fs	TSC1_uc004ccb.3_Frame_Shift_Del_p.T44fs|TSC1_uc011mcq.1_Frame_Shift_Del_p.T44fs|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_Intron|TSC1_uc004ccc.1_Frame_Shift_Del_p.T44fs|TSC1_uc004ccd.2_Frame_Shift_Del_p.T44fs|TSC1_uc004cce.1_Frame_Shift_Del_p.T44fs	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	44					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AATCCACCAAGGTGTTTACAA	0.448			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis									33	13	---	---								-	135802666	G	-	135802666	7	5	22	1	0	1	0	1	0	0	0	0	16602	987	35	0	3442	0	TSC1	9	135802666	Frame_Shift_Del	DEL	G	TCGA-BT-A42C-01A-11D-A23M-08	4405510	135802666	5410765	211	6408										
KCNT1	57582	broad.mit.edu	37	chr9	138650354	138650354	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gctgtgcctcgttttcacggGgtgagtgccggccgtcagtg	16	11	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:138650354G>A	uc011mdq.1	+	10	928	c.854G>A	c.(853-855)GGG>GAG	p.G285E	KCNT1_uc011mdr.1_Missense_Mutation_p.G112E|KCNT1_uc010nbf.2_Missense_Mutation_p.G237E|KCNT1_uc004cgo.1_Missense_Mutation_p.G34E	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	285						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GTTTTCACGGGGTGAGTGCCG	0.612													0	0	0	0.004289	0	33	31										A	138650354	G	A	138650354	3	1	22	1	0	0	0	0	1	0	0	0	8091	1246	43	2	892	2	KCNT1	9	138650354	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2847688	138650354	2563077	212	6409										
SEC16A	9919	broad.mit.edu	37	chr9	139348776	139348776	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggccgtcagggagcgtctgcGgagctgcatgggaacggtgg	20	9	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr9:139348776G>A	uc004chx.2	-	21	6170	c.5861C>T	c.(5860-5862)CCG>CTG	p.P1954L	SEC16A_uc004chs.2_5'Flank|SEC16A_uc004cht.2_5'UTR|SEC16A_uc004chu.2_Missense_Mutation_p.P139L|SEC16A_uc004chv.3_Missense_Mutation_p.P1344L|SEC16A_uc004chw.2_Missense_Mutation_p.P1954L|SEC16A_uc010nbn.2_Missense_Mutation_p.P1954L	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1776	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GAGCGTCTGCGGAGCTGCATG	0.602													0	0	0	0.004672	0	2	5										A	139348776	G	A	139348776	3	1	22	1	0	0	0	0	1	0	0	0	13986	1116	39	2	1260	2	SEC16A	9	139348776	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	698422	139348776	1864655	213	6410										
TUBB8	347688	broad.mit.edu	37	chr10	95170	95170	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccgatctgcgtgagcacgatCtccctcatggccaaggcggg	13	14	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:95170C>T	uc001ifi.2	-	1	9	c.9G>A	c.(7-9)GAG>GAA	p.E3E	TUBB8_uc009xhe.2_Silent_p.E3E|TUBB8_uc010pzs.1_Intron	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	3					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TGAGCACGATCTCCCTCATGG	0.672													0	0	0	0.009096	0	3	8										T	95170	C	T	95170	2	4	22	1	0	0	0	0	0	0	0	1	16758	912	32	1		1	TUBB8	10	95170	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		95170	135439577	214	6411										
CUBN	8029	broad.mit.edu	37	chr10	17107518	17107518	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttttgttacctgttgctgcaCtgattgcttcatagtttatt	7	7	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:17107518C>T	uc001ioo.2	-	22	3180	c.3128G>A	c.(3127-3129)AGT>AAT	p.S1043N		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1043					cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGTTGCTGCACTGATTGCTTC	0.423													0	0	0	0.00361	0	54	217										T	17107518	C	T	17107518	3	4	22	1	0	0	0	0	1	0	0	0	4051	565	20	2	7927	2	CUBN	10	17107518	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	17012348	17107518	118427229	215	6412										
ARMC3	219681	broad.mit.edu	37	chr10	23250840	23250840	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agtgtcgagctaaacttcaaGaactaaatgcaatacctcct	6	10	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:23250840G>T	uc001irm.3	+	7	648	c.565G>T	c.(565-567)GAA>TAA	p.E189*	ARMC3_uc010qcv.1_Nonsense_Mutation_p.E189*|ARMC3_uc010qcw.1_Intron	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	189	ARM 5.						binding				0						TAAACTTCAAGAACTAAATGC	0.333													1	0	0.00198382	0.001984	0.00203612	6	24										T	23250840	G	T	23250840	4	4	22	1	0	0	0	0	0	1	0	0	952	943	33	3	587	3	ARMC3	10	23250840	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6143322	23250840	112283907	216	6413										
AGAP6	414189	broad.mit.edu	37	chr10	51749116	51749116	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agagtcaagcacaatattccAgaggaactctcaaacagaag	8	9	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:51749116A>G	uc001jix.3	+	2	670	c.272A>G	c.(271-273)CAG>CGG	p.Q91R		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	91					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						ACAATATTCCAGAGGAACTCT	0.353													0	0	0	0.001168	0	5	53										G	51749116	A	G	51749116	3	3	22	1	0	0	0	0	1	0	0	0	372	188	7	5	278	5	AGAP6	10	51749116	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	28498276	51749116	83785631	217	6414										
C10orf35	219738	broad.mit.edu	37	chr10	71392625	71392625	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcaggtgccaggctgggtgCtgctcagtcccccttcaatg	14	13	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:71392625C>T	uc001jpq.3	+	4	346	c.176C>T	c.(175-177)GCT>GTT	p.A59V		NM_145306	NP_660349	Q96D05	CJ035_HUMAN	hypothetical protein LOC219738	59						integral to membrane				ovary(1)|skin(1)	2						AGGCTGGGTGCTGCTCAGTCC	0.627													0	0	0	0.001168	0	5	84										T	71392625	C	T	71392625	3	4	22	1	0	0	0	0	1	0	0	0	1603	797	28	2	182	2	C10orf35	10	71392625	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	19643509	71392625	64142122	218	6415										
LRIT1	26103	broad.mit.edu	37	chr10	85991892	85991892	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gttgaagcactttcggcagcGcttctgaagagcactgcagc	12	11	1	3	rs75121307		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:85991892G>A	uc001kcz.1	-	4	1685	c.1663C>T	c.(1663-1665)CGC>TGC	p.R555C		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	555	Cytoplasmic (Potential).					integral to endoplasmic reticulum membrane					0						TTTCGGCAGCGCTTCTGAAGA	0.552													0	0	0	0.002836	0	36	52										A	85991892	G	A	85991892	3	1	22	1	0	0	0	0	1	0	0	0	8947	1087	38	2	212	2	LRIT1	10	85991892	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	14599267	85991892	49542855	219	6416										
STAMBPL1	57559	broad.mit.edu	37	chr10	90672881	90672881	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaatataaagctgaaattctCaaaaaattggagcatcagag	7	5	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:90672881C>G	uc001kfk.2	+	6	867	c.444C>G	c.(442-444)CTC>CTG	p.L148L	STAMBPL1_uc010qmx.1_Silent_p.L148L|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Silent_p.L148L|STAMBPL1_uc001kfn.2_5'UTR	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	148							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		CTGAAATTCTCAAAAAATTGG	0.408													0	0	0	0.002836	0	34	84										G	90672881	C	G	90672881	2	3	22	1	0	0	0	0	0	0	0	1	15250	813	29	1		1	STAMBPL1	10	90672881	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4680989	90672881	44861866	220	6417										
BTAF1	9044	broad.mit.edu	37	chr10	93726464	93726464	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atcacactatatcatcagttCgaagagcagcattggaaact	7	9	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:93726464C>T	uc001khr.2	+	14	1698	c.1600C>T	c.(1600-1602)CGA>TGA	p.R534*	BTAF1_uc001khs.1_Nonsense_Mutation_p.R204*|BTAF1_uc001kht.1_5'UTR	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	534	HEAT 3.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ATCATCAGTTCGAAGAGCAGC	0.338													0	0	0	0.002836	0	30	58										T	93726464	C	T	93726464	4	4	22	1	0	0	0	0	0	1	0	0	1536	876	31	1	1654	1	BTAF1	10	93726464	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	3053583	93726464	41808283	221	6418										
CYP2C18	1562	broad.mit.edu	37	chr10	96454775	96454775	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	attataaagatcagaggtttCttaacttgatggaaaaattc	7	4	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:96454775C>T	uc001kjv.3	+	4	909	c.583C>T	c.(583-585)CTT>TTT	p.L195F	CYP2C18_uc001kjw.3_Missense_Mutation_p.L195F|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	195					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TCAGAGGTTTCTTAACTTGAT	0.408													0	0	0	0.001168	0	6	68										T	96454775	C	T	96454775	3	4	22	1	0	0	0	0	1	0	0	0	4165	913	32	1	597	1	CYP2C18	10	96454775	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2728311	96454775	39079972	222	6419										
BLNK	29760	broad.mit.edu	37	chr10	97951794	97951794	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gttattctgactgtcaataaGaaccaaaggactatgttgat	8	6	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:97951794G>A	uc001kls.3	-	17	1484	c.1306C>T	c.(1306-1308)CTT>TTT	p.L436F	BLNK_uc001kme.3_Missense_Mutation_p.L331F|BLNK_uc001klt.3_Missense_Mutation_p.L327F|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Missense_Mutation_p.L302F|BLNK_uc001klv.3_Missense_Mutation_p.L279F|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Missense_Mutation_p.L413F|BLNK_uc001kly.3_Missense_Mutation_p.L384F|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Missense_Mutation_p.L361F|BLNK_uc001kmb.3_Missense_Mutation_p.L232F|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Missense_Mutation_p.L354F|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	436	SH2.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		CTGTCAATAAGAACCAAAGGA	0.343													0	0	0	0.00361	0	43	41										A	97951794	G	A	97951794	3	1	22	1	0	0	0	0	1	0	0	0	1447	942	33	1	68	1	BLNK	10	97951794	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1497019	97951794	37582953	223	6420										
PI4K2A	55361	broad.mit.edu	37	chr10	99400862	99400862	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cggcaggccgagctggccatCgagcgctgcatctttcccga	13	15	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:99400862C>G	uc001kog.1	+	1	420	c.363C>G	c.(361-363)ATC>ATG	p.I121M	PI4K2A_uc010qoy.1_Intron	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	121					phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		AGCTGGCCATCGAGCGCTGCA	0.711													0	0	0	0.004482	0	8	28										G	99400862	C	G	99400862	3	3	22	1	0	0	0	0	1	0	0	0	11871	874	31	1	365	1	PI4K2A	10	99400862	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1449068	99400862	36133885	224	6421										
ADRB1	153	broad.mit.edu	37	chr10	115804383	115804383	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcgccatcacctcgcccttCcgctaccagagcctgctgac	7	20	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:115804383C>A	uc001lba.2	+	1	578	c.492C>A	c.(490-492)TTC>TTA	p.F164L		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	164	Cytoplasmic (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	CCTCGCCCTTCCGCTACCAGA	0.572													1	0	1.08321e-29	0.00361	1.24546e-29	70	89										A	115804383	C	A	115804383	3	1	22	1	0	0	0	0	1	0	0	0	340	854	30	3	494	3	ADRB1	10	115804383	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	16403521	115804383	19730364	225	6422										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118357370	118357370	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtagaagcaagtttcgagaGtactcctgaagaggtgcgac	13	7	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr10:118357370G>T	uc001lco.1	+	7	623	c.605G>T	c.(604-606)AGT>ATT	p.S202I	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.S202I|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	202					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AGTTTCGAGAGTACTCCTGAA	0.468													1	0	4.96729e-08	0.008871	5.25665e-08	20	86										T	118357370	G	T	118357370	3	4	22	1	0	0	0	0	1	0	0	0	12150	1029	36	4	627	4	PNLIPRP1	10	118357370	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2552987	118357370	17177377	226	6423										
B4GALNT4	338707	broad.mit.edu	37	chr11	373764	373764	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccccaggctcatggcctcccGgaggtactactttgagttgc	11	14	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:373764G>A	uc001lpb.2	+	8	728	c.719G>A	c.(718-720)CGG>CAG	p.R240Q		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	240	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATGGCCTCCCGGAGGTACTAC	0.642													0	0	0	0.00361	0	47	37										A	373764	G	A	373764	3	1	22	1	0	0	0	0	1	0	0	0	1269	1116	39	2	749	2	B4GALNT4	11	373764	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08		373764	134632752	227	6424										
KRTAP5-5	439915	broad.mit.edu	37	chr11	1651190	1651190	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggctgtgggggctgtggctcCggctgtggaggctgtggggg	24	7	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:1651190C>T	uc001lty.2	+	1	158	c.120C>T	c.(118-120)TCC>TCT	p.S40S		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	40						keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		gctgtggctccggctgtggag	0.104													0	0	0	0.00308	0	4	33										T	1651190	C	T	1651190	2	4	22	1	0	0	0	0	0	0	0	1	8564	639	23	2		2	KRTAP5-5	11	1651190	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1277426	1651190	133355326	228	6425										
SYT9	143425	broad.mit.edu	37	chr11	7335059	7335059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acttctctgtgtacgactttGacaggttctctcgtcatgac	8	11	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:7335059G>C	uc001mfe.2	+	3	1168	c.931G>C	c.(931-933)GAC>CAC	p.D311H	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	311	Cytoplasmic (Potential).|C2 1.	Calcium 2 (By similarity).|Calcium 3 (By similarity).|Calcium 1 (By similarity).				cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		GTACGACTTTGACAGGTTCTC	0.473													0	0	0	0.00361	0	69	141										C	7335059	G	C	7335059	3	2	22	1	0	0	0	0	1	0	0	0	15478	1290	45	1	941	1	SYT9	11	7335059	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5683869	7335059	127671457	229	6426										
PAX6	5080	broad.mit.edu	37	chr11	31824258	31824258	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gccgggaggatcacctgcagAattcgggaaatgtcgcacgg	15	10	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:31824258A>T	uc001mtd.3	-	4	1025	c.135T>A	c.(133-135)ATT>ATA	p.I45I	PAX6_uc001mte.3_Silent_p.I45I|PAX6_uc001mtg.3_Silent_p.I45I|PAX6_uc001mtf.3_Silent_p.I45I|PAX6_uc001mth.3_Silent_p.I45I|PAX6_uc009yjr.2_Silent_p.I45I	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	45	Paired.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)					TCACCTGCAGAATTCGGGAAA	0.617									Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				0	0	0	0.004007	0	16	8										T	31824258	A	T	31824258	2	4	22	1	0	0	0	0	0	0	0	1	11483	242	9	5		5	PAX6	11	31824258	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	24489199	31824258	103182258	230	6427										
OR4C46	119749	broad.mit.edu	37	chr11	51515813	51515813	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcatagatcactttatgtgtGatctgaaccctttgctcaac	6	10	4	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:51515813G>C	uc010ric.1	+	1	532	c.532G>C	c.(532-534)GAT>CAT	p.D178H		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTTATGTGTGATCTGAACCC	0.453													0	0	0	0.001368	0	12	192										C	51515813	G	C	51515813	3	2	22	1	0	0	0	0	1	0	0	0	11051	1290	45	1	534	1	OR4C46	11	51515813	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	19691555	51515813	83490703	231	6428										
OR8H2	390151	broad.mit.edu	37	chr11	55872777	55872777	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctaaaaccttagcgaacttaCtgacttccaactatatttcc	3	12	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:55872777C>A	uc010riy.1	+	1	259	c.259C>A	c.(259-261)CTG>ATG	p.L87M		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					AGCGAACTTACTGACTTCCAA	0.438										HNSCC(53;0.14)			1	0	1.66425e-11	0.004878	1.83235e-11	37	632										A	55872777	C	A	55872777	3	1	22	1	0	0	0	0	1	0	0	0	11238	564	20	4	261	4	OR8H2	11	55872777	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4356964	55872777	79133739	232	6429										
RTN4RL2	349667	broad.mit.edu	37	chr11	57243961	57243961	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcctggttccagcgcgcgcgCgtgtccagctccgacgtgac	14	16	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:57243961C>G	uc010rjt.1	+	3	840	c.840C>G	c.(838-840)CGC>CGG	p.R280R		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	280	LRRCT.				axon regeneration	anchored to plasma membrane	receptor activity				0						AGCGCGCGCGCGTGTCCAGCT	0.716													0	0	0	0.001168	0	5	4										G	57243961	C	G	57243961	2	3	22	1	0	0	0	0	0	0	0	1	13732	755	27	4		4	RTN4RL2	11	57243961	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1371184	57243961	77762555	233	6430										
MS4A14	84689	broad.mit.edu	37	chr11	60183468	60183468	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catctaagtctacatcatccCatgtcaaacagtcttctaat	3	12	6	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:60183468C>T	uc001npj.2	+	5	1592	c.1027C>T	c.(1027-1029)CAT>TAT	p.H343Y	MS4A14_uc001npi.2_Missense_Mutation_p.H231Y|MS4A14_uc001npn.2_Missense_Mutation_p.H81Y|MS4A14_uc001npk.2_Missense_Mutation_p.H326Y|MS4A14_uc001npl.2_Missense_Mutation_p.H81Y|MS4A14_uc001npm.2_Missense_Mutation_p.H81Y	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	343						integral to membrane	receptor activity			breast(1)	1						TACATCATCCCATGTCAAACA	0.338													0	0	0	0.006214	0	10	69										T	60183468	C	T	60183468	3	4	22	1	0	0	0	0	1	0	0	0	9858	594	21	2	1045	2	MS4A14	11	60183468	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2939507	60183468	74823048	234	6431										
VWCE	220001	broad.mit.edu	37	chr11	61058340	61058340	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcacactcgggccacctcctGacagcctccatggttgcagg	11	16	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:61058340G>C	uc001nra.2	-	4	634	c.355C>G	c.(355-357)CAG>GAG	p.Q119E	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	119						extracellular region	calcium ion binding			ovary(1)	1						GCCACCTCCTGACAGCCTCCA	0.622													0	0	0	0.006999	0	40	70										C	61058340	G	C	61058340	3	2	22	1	0	0	0	0	1	0	0	0	17242	1299	45	1	2580	1	VWCE	11	61058340	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	874872	61058340	73948176	235	6432										
TMEM179B	374395	broad.mit.edu	37	chr11	62557492	62557492	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agctctgagacagatgctctCgttgggtcacgcctttccca	10	13	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:62557492C>T	uc001nvd.3	+	5	663	c.633C>T	c.(631-633)CTC>CTT	p.L211L		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	211						integral to membrane					0						CAGATGCTCTCGTTGGGTCAC	0.592													0	0	0	0.00361	0	64	107										T	62557492	C	T	62557492	2	4	22	1	0	0	0	0	0	0	0	1	16094	871	31	1		1	TMEM179B	11	62557492	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1499152	62557492	72449024	236	6433										
FAU	2197	broad.mit.edu	37	chr11	64889086	64889086	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagcacgacttgatcttccgGggcaatgccctccagtgagg	13	12	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:64889086G>A	uc001ocx.2	-	3	213	c.106C>T	c.(106-108)CCG>TCG	p.P36S	FAU_uc001ocy.1_Missense_Mutation_p.P36S|MRPL49_uc001ocz.1_5'Flank|MRPL49_uc001oda.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	ubiquitin-like protein fubi and ribosomal	36											0						TGATCTTCCGGGGCAATGCCC	0.612													0	0	0	0.00308	0	8	116										A	64889086	G	A	64889086	3	1	22	1	0	0	0	0	1	0	0	0	5694	1232	43	2	307	2	FAU	11	64889086	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2331594	64889086	70117430	237	6434										
EHBP1L1	254102	broad.mit.edu	37	chr11	65349507	65349507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcaagatgcagggggacccCtgaggctcctccaaggggct	16	12	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:65349507C>T	uc001oeo.3	+	9	1629	c.1364C>T	c.(1363-1365)CCT>CTT	p.P455L	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	455										central_nervous_system(1)	1						AGGGGGACCCCTGAGGCTCCT	0.642													0	0	0	0.00278	0	19	81										T	65349507	C	T	65349507	3	4	22	1	0	0	0	0	1	0	0	0	4976	681	24	2	1398	2	EHBP1L1	11	65349507	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	460421	65349507	69657009	238	6435										
NPAS4	266743	broad.mit.edu	37	chr11	66189921	66189921	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcttcttttcctccctccaGgtggacctggttgcccaggg	10	15	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:66189921G>A	uc001ohx.1	+	3	504	c.328_splice	c.e3-1	p.V110_splice	NPAS4_uc010rpc.1_Splice_Site	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4						transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTCCCTCCAGGTGGACCTGG	0.527													0	0	0	0.00361	0	63	206										A	66189921	G	A	66189921	5	1	22	1	0	0	0	0	0	0	1	0	10565	1014	35	2	337	2	NPAS4	11	66189921	Splice_Site	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	840414	66189921	68816595	239	6436										
ACTN3	89	broad.mit.edu	37	chr11	66325335	66325335	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggagatcaacttcaacacaCtgcagaccaagttgcggctc	9	12	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:66325335C>G	uc001oio.1	+	10	1081	c.1063C>G	c.(1063-1065)CTG>GTG	p.L355V	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	355	Spectrin 1.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						CTTCAACACACTGCAGACCAA	0.587													0	0	0	0.001168	0	5	102										G	66325335	C	G	66325335	3	3	22	1	0	0	0	0	1	0	0	0	206	564	20	4	1101	4	ACTN3	11	66325335	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	135414	66325335	68681181	240	6437										
CCDC87	55231	broad.mit.edu	37	chr11	66359149	66359149	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aagtttctatcagagacccgTacggcagccgcctggaccac	10	14	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:66359149T>A	uc001oiq.3	-	1	1406	c.1338A>T	c.(1336-1338)GTA>GTT	p.V446V	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	446										ovary(1)|skin(1)	2						CAGAGACCCGTACGGCAGCCG	0.532													0	0	0	0.004007	0	16	265										A	66359149	T	A	66359149	2	1	22	1	0	0	0	0	0	0	0	1	2862	1625	57	5		5	CCDC87	11	66359149	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	33814	66359149	68647367	241	6438										
PITPNM1	9600	broad.mit.edu	37	chr11	67269467	67269467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agtcatcagacagtggccctCggcccgtcttgaccgagtga	12	13	3	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:67269467C>T	uc001olx.2	-	4	695	c.506G>A	c.(505-507)CGA>CAA	p.R169Q	PITPNM1_uc001oly.2_Missense_Mutation_p.R169Q|PITPNM1_uc001olz.2_Missense_Mutation_p.R169Q	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	169					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity	p.R169R(1)		lung(2)|central_nervous_system(1)	3						CAGTGGCCCTCGGCCCGTCTT	0.612													0	0	0	0.006999	0	38	85										T	67269467	C	T	67269467	3	4	22	1	0	0	0	0	1	0	0	0	11950	884	31	1	3308	1	PITPNM1	11	67269467	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	910318	67269467	67737049	242	6439										
PITPNM1	9600	broad.mit.edu	37	chr11	67269826	67269826	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtttggctgctgccccccatCaggcaggtaataggtctcaa	11	12	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:67269826C>T	uc001olx.2	-	3	541	c.352G>A	c.(352-354)GAT>AAT	p.D118N	PITPNM1_uc001oly.2_Missense_Mutation_p.D118N|PITPNM1_uc001olz.2_Missense_Mutation_p.D118N	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	118					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGCCCCCCATCAGGCAGGTAA	0.607													0	0	0	0.00361	0	68	199										T	67269826	C	T	67269826	3	4	22	1	0	0	0	0	1	0	0	0	11950	826	29	1	3466	1	PITPNM1	11	67269826	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	359	67269826	67736690	243	6440										
IGHMBP2	3508	broad.mit.edu	37	chr11	68703726	68703726	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgaagttggttttcttgctgAggaccggaggatcaacgtgg	15	6	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:68703726A>G	uc001ook.1	+	13	1880	c.1778A>G	c.(1777-1779)GAG>GGG	p.E593G	IGHMBP2_uc001ool.1_Missense_Mutation_p.E217G|IGHMBP2_uc001oom.1_Missense_Mutation_p.E171G	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	593					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTTCTTGCTGAGGACCGGAGG	0.532													0	0	0	0.010818	0	33	410										G	68703726	A	G	68703726	3	3	22	1	0	0	0	0	1	0	0	0	7591	304	11	5	1828	5	IGHMBP2	11	68703726	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	1433900	68703726	66302790	244	6441										
GRM5	2915	broad.mit.edu	37	chr11	88386506	88386506	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgggagattggagcttgattGtgatgccaccaacagcttct	12	9	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:88386506G>C	uc001pcq.2	-	3	1177	c.977C>G	c.(976-978)ACA>AGA	p.T326R	GRM5_uc009yvm.2_Missense_Mutation_p.T326R	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	326	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GAGCTTGATTGTGATGCCACC	0.453													0	0	0	0.010729	0	11	74										C	88386506	G	C	88386506	3	2	22	1	0	0	0	0	1	0	0	0	6800	1377	48	4	2689	4	GRM5	11	88386506	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	19682780	88386506	46620010	245	6442										
AMOTL1	154810	broad.mit.edu	37	chr11	94533301	94533301	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctccacctgagtaccccttCaagaccaagcaaatgatgtc	6	15	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:94533301C>A	uc001pfb.2	+	3	1115	c.945C>A	c.(943-945)TTC>TTA	p.F315L	AMOTL1_uc001pfc.2_Missense_Mutation_p.F265L	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	315						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				AGTACCCCTTCAAGACCAAGC	0.597													1	0	2.21704e-12	0.00278	2.45088e-12	24	165										A	94533301	C	A	94533301	3	1	22	1	0	0	0	0	1	0	0	0	583	825	29	3	955	3	AMOTL1	11	94533301	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6146795	94533301	40473215	246	6443										
BTG4	54766	broad.mit.edu	37	chr11	111369384	111369384	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccagtgacttctgtatgtttCaaacaagatcgtcatcagct	7	10	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:111369384C>G	uc001plj.2	-	2	303	c.118G>C	c.(118-120)GAA>CAA	p.E40Q	BTG4_uc001plk.2_Missense_Mutation_p.E40Q	NM_017589	NP_060059	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	40					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation						0		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		CTGTATGTTTCAAACAAGATC	0.408													0	0	0	0.004656	0	28	10										G	111369384	C	G	111369384	3	3	22	1	0	0	0	0	1	0	0	0	1556	835	29	1	573	1	BTG4	11	111369384	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	16836083	111369384	23637132	247	6444										
GRAMD1B	57476	broad.mit.edu	37	chr11	123483472	123483472	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tctggcttgctcctcagggtCtccacagagctgcgctatcg	11	14	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:123483472C>G	uc001pyx.2	+	14	1823	c.1494C>G	c.(1492-1494)GTC>GTG	p.V498V	GRAMD1B_uc001pyw.2_Silent_p.V505V|GRAMD1B_uc010rzw.1_Silent_p.V458V|GRAMD1B_uc010rzx.1_Silent_p.V458V|GRAMD1B_uc001pyy.2_Silent_p.V189V	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	498						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TCCTCAGGGTCTCCACAGAGC	0.522													0	0	0	0.00499	0	16	6										G	123483472	C	G	123483472	2	3	22	1	0	0	0	0	0	0	0	1	6748	900	32	1		1	GRAMD1B	11	123483472	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	12114088	123483472	11523044	248	6445										
ROBO3	64221	broad.mit.edu	37	chr11	124747869	124747869	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtatctagctcagacggccaGgggcacggccgcccctggcg	15	15	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr11:124747869G>A	uc001qbc.2	+	21	3215	c.3023G>A	c.(3022-3024)AGG>AAG	p.R1008K	ROBO3_uc010saq.1_3'UTR|ROBO3_uc001qbd.2_5'UTR|ROBO3_uc010sar.1_Missense_Mutation_p.R57K|ROBO3_uc001qbe.2_5'UTR|ROBO3_uc001qbf.1_5'UTR	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1008	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CAGACGGCCAGGGGCACGGCC	0.597													0	0	0	0.004672	0	3	17										A	124747869	G	A	124747869	3	1	22	1	0	0	0	0	1	0	0	0	13515	1000	35	2	3105	2	ROBO3	11	124747869	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1264397	124747869	10258647	249	6446										
SLC6A12	6539	broad.mit.edu	37	chr12	306659	306659	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgttcaggaagcagagggcgAtgcagtccctgtgggagtgg	18	7	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:306659A>C	uc001qhz.2	-	11	1502	c.959T>G	c.(958-960)ATC>AGC	p.I320S	SLC6A12_uc001qhx.2_5'UTR|SLC6A12_uc001qhy.2_5'UTR|SLC6A12_uc001qia.2_Missense_Mutation_p.I320S|SLC6A12_uc001qib.2_Missense_Mutation_p.I320S|SLC6A12_uc009zdh.1_Missense_Mutation_p.I320S	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	320	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			GCAGAGGGCGATGCAGTCCCT	0.378													0	0	0	0.000602	0	4	36										C	306659	A	C	306659	3	2	22	1	0	0	0	0	1	0	0	0	14675	333	12	5	913	5	SLC6A12	12	306659	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08		306659	133545236	250	6447										
CCDC77	84318	broad.mit.edu	37	chr12	550970	550970	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atgcccgggcaaaccaggatCttgcccttctgtgtgaggtc	12	12	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:550970C>A	uc001qig.2	+	13	1531	c.1351C>A	c.(1351-1353)CTT>ATT	p.L451I	CCDC77_uc009zdk.2_Missense_Mutation_p.L419I|CCDC77_uc010sdp.1_Missense_Mutation_p.L419I|CCDC77_uc010sdq.1_Missense_Mutation_p.L419I	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	451	Potential.					centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AAACCAGGATCTTGCCCTTCT	0.433													1	0	7.03913e-09	0.001368	7.59668e-09	13	116										A	550970	C	A	550970	3	1	22	1	0	0	0	0	1	0	0	0	2851	913	32	3	1393	3	CCDC77	12	550970	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	244311	550970	133300925	251	6448										
WNK1	65125	broad.mit.edu	37	chr12	994879	994879	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agccccatactcattgtcctGaagtagattctgatacacaa	6	11	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:994879G>A	uc001qio.3	+	19	5416	c.4909G>A	c.(4909-4911)GAA>AAA	p.E1637K	WNK1_uc001qip.3_Missense_Mutation_p.E1390K|WNK1_uc001qir.3_Missense_Mutation_p.E810K	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1637					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCATTGTCCTGAAGTAGATTC	0.473													0	0	0	0.00361	0	71	68										A	994879	G	A	994879	3	1	22	1	0	0	0	0	1	0	0	0	17374	1291	45	1	6485	1	WNK1	12	994879	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	443909	994879	132857016	252	6449										
WNK1	65125	broad.mit.edu	37	chr12	994963	994963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agctgcggtctctgttcagtGaacacagctcatctggagct	11	11	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:994963G>A	uc001qio.3	+	19	5500	c.4993G>A	c.(4993-4995)GAA>AAA	p.E1665K	WNK1_uc001qip.3_Missense_Mutation_p.E1418K|WNK1_uc001qir.3_Missense_Mutation_p.E838K	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1665					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCTGTTCAGTGAACACAGCTC	0.478													0	0	0	0.00361	0	57	53										A	994963	G	A	994963	3	1	22	1	0	0	0	0	1	0	0	0	17374	1291	45	1	6569	1	WNK1	12	994963	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	84	994963	132856932	253	6450										
DYRK4	8798	broad.mit.edu	37	chr12	4722735	4722735	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agatagccccacgaagcatgTtcagcattcaggtgatcagc	10	11	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:4722735T>C	uc001qmx.2	+	13	1539	c.1379T>C	c.(1378-1380)GTT>GCT	p.V460A	DYRK4_uc001qmy.1_Missense_Mutation_p.V459A|DYRK4_uc001qmz.1_Missense_Mutation_p.V173A|DYRK4_uc001qna.1_Missense_Mutation_p.V96A|DYRK4_uc010ser.1_Missense_Mutation_p.V97A	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	460						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			ACGAAGCATGTTCAGCATTCA	0.493													0	0	0	0.008291	0	10	89										C	4722735	T	C	4722735	3	2	22	1	0	0	0	0	1	0	0	0	4858	1725	60	5	1421	5	DYRK4	12	4722735	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	3727772	4722735	129129160	254	6451										
GRIN2B	2904	broad.mit.edu	37	chr12	13717440	13717440	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgagccattcacaccagacAggttagccatgttcttggcc	10	12	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:13717440A>C	uc001rbt.2	-	13	2911	c.2732T>G	c.(2731-2733)CTG>CGG	p.L911R		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	911	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CACACCAGACAGGTTAGCCAT	0.582													0	0	0	0.00361	0	65	270										C	13717440	A	C	13717440	3	2	22	1	0	0	0	0	1	0	0	0	6780	188	7	5	1726	5	GRIN2B	12	13717440	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	8994705	13717440	120134455	255	6452										
SOX5	6660	broad.mit.edu	37	chr12	23999053	23999053	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcgccactctgtcgcccaccTtcttctgccttctgaggtga	8	16	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:23999053T>A	uc001rfw.2	-	3	447	c.345A>T	c.(343-345)GAA>GAT	p.E115D	SOX5_uc001rfx.2_Missense_Mutation_p.E102D|SOX5_uc001rfy.2_Missense_Mutation_p.E102D|SOX5_uc010siv.1_Missense_Mutation_p.E102D|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.E67D|SOX5_uc001rga.2_Missense_Mutation_p.E80D	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	115					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GTCGCCCACCTTCTTCTGCCT	0.478													0	0	0	0.00245	0	13	155										A	23999053	T	A	23999053	3	1	22	1	0	0	0	0	1	0	0	0	14954	1606	56	5	2008	5	SOX5	12	23999053	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	10281613	23999053	109852842	256	6453										
MLL2	8085	broad.mit.edu	37	chr12	49431524	49431525	+	Missense_Mutation	DNP	TC	TC	CA													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttttccagcagggaggatccTcctgggccactcagtgggct							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			TC	CA	TC	TC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:49431524_49431525TC>CA	uc001rta.3	-	34	9614_9615	c.9614_9615GA>TG	c.(9613-9615)GGA>GTG	p.G3205V		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3205					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGAGGATCCTCCTGGGCCACT	0.599			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004672	0	4	21										CA	49431525	TC	CA	49431524	3	2	22	1	0	0	0	0	1	0	0	0	9621	1538	54	5	7082	5	MLL2	12	49431524	Missense_Mutation	DNP	TC	TCGA-BT-A42C-01A-11D-A23M-08	25432471	49431524	84420371	257	6454										
ERBB3	2065	broad.mit.edu	37	chr12	56480394	56480394	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	attgactggagggacatcgtGagggaccgagatgctgagat	16	6	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:56480394G>C	uc001sjh.2	+	4	694	c.501G>C	c.(499-501)GTG>GTC	p.V167V	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Silent_p.V108V|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	167	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GGGACATCGTGAGGGACCGAG	0.493													0	0	0	0.012213	0	30	254										C	56480394	G	C	56480394	2	2	22	1	0	0	0	0	0	0	0	1	5208	1277	45	1		1	ERBB3	12	56480394	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	7048870	56480394	77371501	258	6455										
PIP4K2C	79837	broad.mit.edu	37	chr12	57985171	57985171	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aagaccaagaagaagcatttCgtgcagcagaaggtgaaggt	13	6	0	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:57985171C>T	uc001sou.2	+	1	230	c.99C>T	c.(97-99)TTC>TTT	p.F33F	PIP4K2C_uc001sot.2_Silent_p.F33F|PIP4K2C_uc010srs.1_Silent_p.F33F|PIP4K2C_uc010srt.1_Silent_p.F33F	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	33						cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					AGAAGCATTTCGTGCAGCAGA	0.662													0	0	0	0.00361	0	101	258										T	57985171	C	T	57985171	2	4	22	1	0	0	0	0	0	0	0	1	11938	883	31	1		1	PIP4K2C	12	57985171	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1504777	57985171	75866724	259	6456										
IRAK3	11213	broad.mit.edu	37	chr12	66639035	66639035	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcaaagttaagaccatcaaTggatgaagtgagtatataca	10	5	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:66639035T>C	uc001sth.2	+	11	1409	c.1307T>C	c.(1306-1308)ATG>ACG	p.M436T	IRAK3_uc010ssy.1_Missense_Mutation_p.M375T	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	436	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		AGACCATCAATGGATGAAGTG	0.418													0	0	0	0.00361	0	77	372										C	66639035	T	C	66639035	3	2	22	1	0	0	0	0	1	0	0	0	7824	1464	51	5	1349	5	IRAK3	12	66639035	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	8653864	66639035	67212860	260	6457										
IFNG	3458	broad.mit.edu	37	chr12	68553296	68553296	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acttacaaaatatttcttaaGgttttctgcttcttttacat	3	7	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:68553296G>C	uc001stw.1	-	1	226	c.100C>G	c.(100-102)CTT>GTT	p.L34V		NM_000619	NP_000610	P01579	IFNG_HUMAN	interferon, gamma precursor	34					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	TATTTCTTAAGGTTTTCTGCT	0.363													0	0	0	0.000602	0	5	51										C	68553296	G	C	68553296	3	2	22	1	0	0	0	0	1	0	0	0	7548	1000	35	4	416	4	IFNG	12	68553296	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1914261	68553296	65298599	261	6458										
CORO1C	23603	broad.mit.edu	37	chr12	109095064	109095064	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgcttgcccaaatacatgccGaaacttgctctgtcgtacca	7	14	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:109095064G>A	uc001tnj.2	-	2	127	c.31C>T	c.(31-33)CGG>TGG	p.R11W	CORO1C_uc009zva.2_Missense_Mutation_p.R64W|CORO1C_uc010sxf.1_Missense_Mutation_p.R11W	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	11					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						AATACATGCCGAAACTTGCTC	0.443													0	0	0	0.010729	0	10	165										A	109095064	G	A	109095064	3	1	22	1	0	0	0	0	1	0	0	0	3755	1057	37	1	1433	1	CORO1C	12	109095064	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	40541768	109095064	24756831	262	6459										
KNTC1	9735	broad.mit.edu	37	chr12	123072359	123072359	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccctaagatttgtggttggtTcatttggtacctgtcttcag	10	8	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:123072359T>G	uc001ucv.2	+	39	3995	c.3832T>G	c.(3832-3834)TCA>GCA	p.S1278A	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1278					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TGTGGTTGGTTCATTTGGTAC	0.423													0	0	0	0.009096	0	3	37										G	123072359	T	G	123072359	3	3	22	1	0	0	0	0	1	0	0	0	8428	1783	62	5	3982	5	KNTC1	12	123072359	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	13977295	123072359	10779536	263	6460										
KNTC1	9735	broad.mit.edu	37	chr12	123078909	123078909	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagaatatagatatggacacAagcctcattttggaatattg	9	5	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:123078909A>C	uc001ucv.2	+	43	4495	c.4332A>C	c.(4330-4332)ACA>ACC	p.T1444T	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1444					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		ATATGGACACAAGCCTCATTT	0.323													0	0	0	0.003954	0	24	42										C	123078909	A	C	123078909	2	2	22	1	0	0	0	0	0	0	0	1	8428	117	5	5		5	KNTC1	12	123078909	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	6550	123078909	10772986	264	6461										
MPHOSPH9	10198	broad.mit.edu	37	chr12	123687540	123687540	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agtccggggaaaaggatattCtgtcatcaagggcattcgga	13	7	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:123687540C>A	uc001uel.2	-	6	1063	c.956G>T	c.(955-957)AGA>ATA	p.R319I	MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	319					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		AAAGGATATTCTGTCATCAAG	0.463													1	0	2.01807e-28	0.00361	2.31547e-28	52	177										A	123687540	C	A	123687540	3	1	22	1	0	0	0	0	1	0	0	0	9728	913	32	3	2199	3	MPHOSPH9	12	123687540	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	608631	123687540	10164355	265	6462										
GTF2H3	2967	broad.mit.edu	37	chr12	124144458	124144458	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcattgaaattggttatgtCtgttctgtgtgtttgtcaag	10	5	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:124144458C>A	uc001ufo.1	+	11	827	c.801C>A	c.(799-801)GTC>GTA	p.V267V	GTF2H3_uc010tau.1_Silent_p.V226V	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	267					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		TTGGTTATGTCTGTTCTGTGT	0.403								NER					1	0	1.45844e-13	0.002836	1.62214e-13	35	62										A	124144458	C	A	124144458	2	1	22	1	0	0	0	0	0	0	0	1	6864	900	32	3		3	GTF2H3	12	124144458	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	456918	124144458	9707437	266	6463										
ULK1	8408	broad.mit.edu	37	chr12	132379547	132379547	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcccccggcccgcctgcgccAtggagcccggccgcggcggc	16	21	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:132379547A>G	uc001uje.2	+	1	269	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	1					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		cgccTGCGCCATGGAGCCCGG	0.373													0	0	0	0.000602	0	4	7										G	132379547	A	G	132379547	3	3	22	1	0	0	0	0	1	0	0	0	16972	217	8	5	3	5	ULK1	12	132379547	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	8235089	132379547	1472348	267	6464										
EP400	57634	broad.mit.edu	37	chr12	132504716	132504716	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgctccacagggcccgcttcGaggacggccgcccatcgcca	12	18	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr12:132504716G>A	uc001ujn.2	+	21	4435	c.4400G>A	c.(4399-4401)CGA>CAA	p.R1467Q	EP400_uc001ujl.2_Missense_Mutation_p.R1466Q|EP400_uc001ujm.2_Missense_Mutation_p.R1467Q	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1503					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCCCGCTTCGAGGACGGCCG	0.652													0	0	0	0.007291	0	27	94										A	132504716	G	A	132504716	3	1	22	1	0	0	0	0	1	0	0	0	5149	1058	37	1	4479	1	EP400	12	132504716	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	125169	132504716	1347179	268	6465										
ATP12A	479	broad.mit.edu	37	chr13	25276099	25276099	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atggttactggtgatcatccCatcacagccaaagctattgc	8	11	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:25276099C>A	uc001upp.2	+	14	2095	c.1908C>A	c.(1906-1908)CCC>CCA	p.P636P	ATP12A_uc010aaa.2_Silent_p.P642P	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	636	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GTGATCATCCCATCACAGCCA	0.478													1	0	7.93312e-07	0.00245	8.33054e-07	13	154										A	25276099	C	A	25276099	2	1	22	1	0	0	0	0	0	0	0	1	1122	581	21	4		4	ATP12A	13	25276099	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		25276099	89893779	269	6466										
ATP12A	479	broad.mit.edu	37	chr13	25281419	25281419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agaaacctctctgcctaggtCgcctgatctttgacaacctc	7	14	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:25281419C>T	uc001upp.2	+	17	2528	c.2341C>T	c.(2341-2343)CGC>TGC	p.R781C	ATP12A_uc010aaa.2_Missense_Mutation_p.R787C	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	781	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGCCTAGGTCGCCTGATCTT	0.532													0	0	0	0.00361	0	52	130										T	25281419	C	T	25281419	3	4	22	1	0	0	0	0	1	0	0	0	1122	884	31	1	2425	1	ATP12A	13	25281419	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5320	25281419	89888459	270	6467										
BRCA2	675	broad.mit.edu	37	chr13	32936814	32936814	+	Missense_Mutation	SNP	C	C	T													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taagcccagaaagggtgcttCttcaactaaaatacaggcaa							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:32936814C>T	uc001uub.1	+	17	8187	c.7960C>T	c.(7960-7962)CTT>TTT	p.L2654F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2654					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGGGTGCTTCTTCAACTAAA	0.373			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00333	0	22	25										T	32936814	C	T	32936814	3	4	22	1	0	0	0	0	1	0	0	0	1499	913	32	1	8022	1	BRCA2	13	32936814	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	7655395	32936814	82233064	271	6468	29	2								
BRCA2	675	broad.mit.edu	37	chr13	32936817	32936817	+	Nonsense_Mutation	SNP	C	C	T													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcccagaaagggtgcttcttCaactaaaatacaggcaagtt							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:32936817C>T	uc001uub.1	+	17	8190	c.7963C>T	c.(7963-7965)CAA>TAA	p.Q2655*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2655					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGTGCTTCTTCAACTAAAATA	0.378			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00333	0	22	25										T	32936817	C	T	32936817	4	4	22	1	0	0	0	0	0	1	0	0	1499	827	29	1	8025	1	BRCA2	13	32936817	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	3	32936817	82233061	272	6469	29	2								
BRCA2	675	broad.mit.edu	37	chr13	32937596	32937596	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagttggtcagaagattattCttcatggagcagaactggtg	12	6	3	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:32937596C>T	uc001uub.1	+	18	8484	c.8257C>T	c.(8257-8259)CTT>TTT	p.L2753F		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2753					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAAGATTATTCTTCATGGAGC	0.438			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.012319	0	21	65										T	32937596	C	T	32937596	3	4	22	1	0	0	0	0	1	0	0	0	1499	913	32	1	8323	1	BRCA2	13	32937596	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	779	32937596	82232282	273	6470										
KLF5	688	broad.mit.edu	37	chr13	73636804	73636804	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taactcacaaaacatccaacCtgtcagatacaatagaagga	5	10	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:73636804C>G	uc001vje.2	+	2	1391	c.1067C>G	c.(1066-1068)CCT>CGT	p.P356R	KLF5_uc001vjd.2_Missense_Mutation_p.P265R	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	356					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		AACATCCAACCTGTCAGATAC	0.453													0	0	0	0.007413	0	18	89										G	73636804	C	G	73636804	3	3	22	1	0	0	0	0	1	0	0	0	8349	681	24	4	1073	4	KLF5	13	73636804	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	40699208	73636804	41533074	274	6471										
DCT	1638	broad.mit.edu	37	chr13	95121217	95121217	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaggaatggatgttctgccgAatcactggtggtttcttccg	12	8	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:95121217A>C	uc001vlv.3	-	2	805	c.378T>G	c.(376-378)ATT>ATG	p.I126M	DCT_uc010afh.2_Missense_Mutation_p.I126M	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	126	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TGTTCTGCCGAATCACTGGTG	0.507													0	0	0	0.00361	0	94	202										C	95121217	A	C	95121217	3	2	22	1	0	0	0	0	1	0	0	0	4304	242	9	5	1316	5	DCT	13	95121217	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	21484413	95121217	20048661	275	6472										
RASA3	22821	broad.mit.edu	37	chr13	114778667	114778667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgggggagagaatggcgggcGcaaagaacctcaggaagatg	18	6	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr13:114778667G>A	uc001vui.2	-	15	1594	c.1463C>T	c.(1462-1464)GCG>GTG	p.A488V	RASA3_uc010tkk.1_Missense_Mutation_p.A456V|RASA3_uc001vuj.2_Missense_Mutation_p.A105V	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	488	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			AATGGCGGGCGCAAAGAACCT	0.617													0	0	0	0.003954	0	18	6										A	114778667	G	A	114778667	3	1	22	1	0	0	0	0	1	0	0	0	13062	1087	38	2	1081	2	RASA3	13	114778667	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	19657450	114778667	391211	276	6473										
OR4Q3	441669	broad.mit.edu	37	chr14	20215775	20215775	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caatctcctatgtattatttTttaggtcatctctctttcat	3	9	5	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:20215775T>C	uc010tkt.1	+	1	189	c.189T>C	c.(187-189)TTT>TTC	p.F63F		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	63	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTATTATTTTTTAGGTCATC	0.413													0	0	0	0.00361	0	59	143										C	20215775	T	C	20215775	2	2	22	1	0	0	0	0	0	0	0	1	11081	1838	64	5		5	OR4Q3	14	20215775	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08		20215775	87133765	277	6474										
ACIN1	22985	broad.mit.edu	37	chr14	23533347	23533347	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cggcatattttcagccccttGtcatgggtcccatcatcgcc	8	15	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:23533347G>T	uc001wit.3	-	12	3064	c.2736C>A	c.(2734-2736)GAC>GAA	p.D912E	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.D154E|ACIN1_uc001wiq.3_Missense_Mutation_p.D154E|ACIN1_uc001wir.3_Missense_Mutation_p.D185E|ACIN1_uc001wis.3_Missense_Mutation_p.D593E|ACIN1_uc010akg.2_Missense_Mutation_p.D899E	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	912					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCAGCCCCTTGTCATGGGTCC	0.562													1	0	1.58986e-06	0.008291	1.6631e-06	11	170										T	23533347	G	T	23533347	3	4	22	1	0	0	0	0	1	0	0	0	142	1368	48	4	1321	4	ACIN1	14	23533347	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3317572	23533347	83816193	278	6475										
EFS	10278	broad.mit.edu	37	chr14	23829056	23829056	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atagatggggggccccggctCccggcctccttcccactcca	11	18	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:23829056C>T	uc001wjo.2	-	4	1239	c.631G>A	c.(631-633)GAG>AAG	p.E211K	EFS_uc001wjp.2_Missense_Mutation_p.E118K|EFS_uc010tnm.1_Intron	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	211	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GGCCCCGGCTCCCGGCCTCCT	0.617													0	0	0	0.010818	0	31	137										T	23829056	C	T	23829056	3	4	22	1	0	0	0	0	1	0	0	0	4959	864	30	1	1066	1	EFS	14	23829056	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	295709	23829056	83520484	279	6476										
JPH4	84502	broad.mit.edu	37	chr14	24045009	24045009	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccgaagggccagaggcaggaGactgcggacgcgcccgccgt	17	14	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:24045009G>C	uc001wkq.2	-	4	1954	c.1036C>G	c.(1036-1038)CTC>GTC	p.L346V	JPH4_uc010tnr.1_5'Flank|JPH4_uc001wkr.2_Missense_Mutation_p.L346V|JPH4_uc001wks.2_Missense_Mutation_p.L346V	NM_032452	NP_115828	Q96JJ6	JPH4_HUMAN	junctophilin 4	346	Cytoplasmic (Potential).|MORN 8.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				ovary(1)|pancreas(1)	2	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		AGAGGCAGGAGACTGCGGACG	0.731													0	0	0	0.001984	0	5	4										C	24045009	G	C	24045009	3	2	22	1	0	0	0	0	1	0	0	0	7963	942	33	1	866	1	JPH4	14	24045009	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	215953	24045009	83304531	280	6477										
PNN	5411	broad.mit.edu	37	chr14	39646875	39646875	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccaggatcaaaatatggatGaaaagggaaagcaaaggtat	11	4	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:39646875G>A	uc001wuw.3	+	5	503	c.406G>A	c.(406-408)GAA>AAA	p.E136K		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	136	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		AAATATGGATGAAAAGGGAAA	0.403													0	0	0	0.00361	0	57	134										A	39646875	G	A	39646875	3	1	22	1	0	0	0	0	1	0	0	0	12160	1291	45	1	424	1	PNN	14	39646875	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	15601866	39646875	67702665	281	6478										
MDGA2	161357	broad.mit.edu	37	chr14	47504376	47504376	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgatccatcaggcattgcaaCttctttatccgctctagacc	6	13	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:47504376C>G	uc001wwj.3	-	8	1646	c.1450G>C	c.(1450-1452)GTT>CTT	p.V484L	MDGA2_uc001wwi.3_Missense_Mutation_p.V255L|MDGA2_uc010ani.2_Missense_Mutation_p.V44L	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	484	Ig-like 5.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						GGCATTGCAACTTCTTTATCC	0.418													0	0	0	0.00361	0	57	108										G	47504376	C	G	47504376	3	3	22	1	0	0	0	0	1	0	0	0	9407	565	20	4	1460	4	MDGA2	14	47504376	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	7857501	47504376	59845164	282	6479										
NIN	51199	broad.mit.edu	37	chr14	51288736	51288736	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aaactgtcaaacagctccttGagtcgggcctcatgctggtc	10	12	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:51288736G>C	uc001wym.2	-	3	230	c.39C>G	c.(37-39)CTC>CTG	p.L13L	NIN_uc001wyi.2_Silent_p.L13L|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.L13L|NIN_uc010tqp.1_Intron|NIN_uc001wyo.2_Silent_p.L13L|NIN_uc001wyp.1_Intron	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	13	EF-hand 1.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					ACAGCTCCTTGAGTCGGGCCT	0.587			T	PDGFRB	MPD								0	0	0	0.00361	0	147	301										C	51288736	G	C	51288736	2	2	22	1	0	0	0	0	0	0	0	1	10417	1277	45	1		1	NIN	14	51288736	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3784360	51288736	56060804	283	6480										
DAAM1	23002	broad.mit.edu	37	chr14	59791171	59791171	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acgaaaattcaacattagatAggtaagtcagactattatga	7	5	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:59791171A>T	uc001xdz.1	+	8	1113	c.988A>T	c.(988-990)AGG>TGG	p.R330W	DAAM1_uc001xea.1_Missense_Mutation_p.R330W|DAAM1_uc001xeb.1_Missense_Mutation_p.R330W	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	330	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AACATTAGATAGGTAAGTCAG	0.289													0	0	0	0.001984	0	7	27										T	59791171	A	T	59791171	3	4	22	1	0	0	0	0	1	0	0	0	4215	434	15	5	1014	5	DAAM1	14	59791171	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	8502435	59791171	47558369	284	6481										
SLC10A1	6554	broad.mit.edu	37	chr14	70252841	70252841	+	Frame_Shift_Del	DEL	C	C	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acatagcgcatgtattgtggCcgtttggatttgaggacgat							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:70252841delC	uc001xlr.2	-	2	674	c.540delG	c.(538-540)CGGfs	p.R180fs		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	180					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		TGTATTGTGGCCGTTTGGATT	0.438																		36	116	---	---								-	70252841	C	-	70252841	7	5	22	1	0	1	0	1	0	0	0	0	14373	726	26	0	525	0	SLC10A1	14	70252841	Frame_Shift_Del	DEL	C	TCGA-BT-A42C-01A-11D-A23M-08	10461670	70252841	37096699	285	6482										
C14orf115	55237	broad.mit.edu	37	chr14	74825233	74825233	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aggagaaggaggctggcaggGatgtgacagctgtgatggcc	19	6	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:74825233G>T	uc001xpw.3	+	2	1938	c.1747G>T	c.(1747-1749)GAT>TAT	p.D583Y		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	583					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GGCTGGCAGGGATGTGACAGC	0.652													1	0	0.00829132	0.008291	0.0084463	11	108										T	74825233	G	T	74825233	3	4	22	1	0	0	0	0	1	0	0	0	1740	1174	41	3	1749	3	C14orf115	14	74825233	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4572392	74825233	32524307	286	6483										
KIAA1409	57578	broad.mit.edu	37	chr14	94004479	94004479	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgggggccgctgcggagactCacctctatcagacctctcct	11	15	4	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr14:94004479C>T	uc001ybv.1	+	9	819	c.736C>T	c.(736-738)CAC>TAC	p.H246Y	KIAA1409_uc001ybs.1_Missense_Mutation_p.H246Y|KIAA1409_uc001ybu.1_Missense_Mutation_p.H184Y	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	423						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGCGGAGACTCACCTCTATCA	0.592													0	0	0	0.006214	0	10	59										T	94004479	C	T	94004479	3	4	22	1	0	0	0	0	1	0	0	0	8230	826	29	1	770	1	KIAA1409	14	94004479	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	19179246	94004479	13345061	287	6484										
RYR3	6263	broad.mit.edu	37	chr15	34080596	34080596	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctcatcctggacgagttcgCggtcctctgcagagatctct	10	14	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:34080596C>T	uc001zhi.2	+	67	9837	c.9767C>T	c.(9766-9768)GCG>GTG	p.A3256V	RYR3_uc010bar.2_Missense_Mutation_p.A3256V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3256					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GACGAGTTCGCGGTCCTCTGC	0.567													0	0	0	0.00245	0	15	86										T	34080596	C	T	34080596	3	4	22	1	0	0	0	0	1	0	0	0	13770	768	27	2	10033	2	RYR3	15	34080596	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		34080596	68450796	288	6485										
RPUSD2	27079	broad.mit.edu	37	chr15	40861663	40861663	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagaaacagtgtctacccagGttgggacagagggcgggctg	16	9	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:40861663G>T	uc001zmd.1	+	1	127	c.127G>T	c.(127-129)GTT>TTT	p.V43F		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	43					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		GTCTACCCAGGTTGGGACAGA	0.627													1	0	1.10923e-09	0.00278	1.20906e-09	25	40										T	40861663	G	T	40861663	3	4	22	1	0	0	0	0	1	0	0	0	13667	1261	44	4	129	4	RPUSD2	15	40861663	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	6781067	40861663	61669729	289	6486										
CASC5	57082	broad.mit.edu	37	chr15	40913273	40913273	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atgaaaataacagtaatattActaggctctttagagaaaaa	6	4	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:40913273A>T	uc010bbs.1	+	11	1050	c.889A>T	c.(889-891)ACT>TCT	p.T297S	CASC5_uc010ucq.1_Missense_Mutation_p.T121S|CASC5_uc001zme.2_Missense_Mutation_p.T271S|CASC5_uc010bbt.1_Missense_Mutation_p.T271S	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	297	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAGTAATATTACTAGGCTCTT	0.373													0	0	0	0.009096	0	4	26										T	40913273	A	T	40913273	3	4	22	1	0	0	0	0	1	0	0	0	2663	391	14	5	927	5	CASC5	15	40913273	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	51610	40913273	61618119	290	6487										
MGA	23269	broad.mit.edu	37	chr15	42003201	42003201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttcagtggccgaactaaatCatcttataaatccattttac	4	9	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:42003201C>T	uc001zog.1	+	8	2829	c.2738C>T	c.(2737-2739)TCA>TTA	p.S913L	MGA_uc010ucy.1_Missense_Mutation_p.S913L|MGA_uc010ucz.1_Missense_Mutation_p.S913L	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	913						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CGAACTAAATCATCTTATAAA	0.403													0	0	0	0.004878	0	38	101										T	42003201	C	T	42003201	3	4	22	1	0	0	0	0	1	0	0	0	9540	838	29	1	2764	1	MGA	15	42003201	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1089928	42003201	60528191	291	6488										
SPG11	80208	broad.mit.edu	37	chr15	44951440	44951440	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtaggatgacacatttgttGatgaacagtaatgatgtgtt	11	3	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:44951440G>A	uc001ztx.2	-	3	535	c.504C>T	c.(502-504)ATC>ATT	p.I168I	SPG11_uc010ueh.1_Silent_p.I168I|SPG11_uc010uei.1_Silent_p.I168I|SPG11_uc001zua.1_Silent_p.I168I	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	168	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CACATTTGTTGATGAACAGTA	0.358													0	0	0	0.00499	0	16	53										A	44951440	G	A	44951440	2	1	22	1	0	0	0	0	0	0	0	1	15040	1280	45	1		1	SPG11	15	44951440	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2948239	44951440	57579952	292	6489										
SLC27A2	11001	broad.mit.edu	37	chr15	50526106	50526106	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggcctccatcaaaatgaaaGaaaaccatgaatttgatgga	8	7	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:50526106G>C	uc001zxw.2	+	9	1829	c.1597G>C	c.(1597-1599)GAA>CAA	p.E533Q	SLC27A2_uc010bes.2_Missense_Mutation_p.E480Q|SLC27A2_uc001zxx.2_Missense_Mutation_p.E298Q	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	533	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CAAAATGAAAGAAAACCATGA	0.373													0	0	0	0.001984	0	7	40										C	50526106	G	C	50526106	3	2	22	1	0	0	0	0	1	0	0	0	14526	943	33	1	1631	1	SLC27A2	15	50526106	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5574666	50526106	52005286	293	6490										
HERC1	8925	broad.mit.edu	37	chr15	64017588	64017588	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggagacacaggggagccctgAagcatgccaccaagacaccg	13	13	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:64017588A>C	uc002amp.2	-	18	3619	c.3471T>G	c.(3469-3471)CTT>CTG	p.L1157L	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1157					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GGGAGCCCTGAAGCATGCCAC	0.512													0	0	0	0.006122	0	19	110										C	64017588	A	C	64017588	2	2	22	1	0	0	0	0	0	0	0	1	7057	233	9	5		5	HERC1	15	64017588	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	13491482	64017588	38513804	294	6491										
EDC3	80153	broad.mit.edu	37	chr15	74963915	74963915	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caacatcctggctcttcacaTctgtcctcttagggatattc	6	13	4	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:74963915T>G	uc002ayn.2	-	6	853	c.365A>C	c.(364-366)GAT>GCT	p.D122A	EDC3_uc002ayo.2_Missense_Mutation_p.D122A|EDC3_uc002aym.2_Missense_Mutation_p.D122A	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	122					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						GCTCTTCACATCTGTCCTCTT	0.522													0	0	0	0.004482	0	9	146										G	74963915	T	G	74963915	3	3	22	1	0	0	0	0	1	0	0	0	4907	1435	50	5	1181	5	EDC3	15	74963915	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	10946327	74963915	27567477	295	6492										
EFTUD1	79631	broad.mit.edu	37	chr15	82443993	82443993	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcttctcaaaggcctcagaGcagccatcttgtagctcttg	8	13	5	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:82443993G>A	uc002bgt.1	-	18	2971	c.2802C>T	c.(2800-2802)TGC>TGT	p.C934C	EFTUD1_uc002bgs.1_Silent_p.C305C|EFTUD1_uc002bgu.1_Silent_p.C883C	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	934					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						AGGCCTCAGAGCAGCCATCTT	0.458													0	0	0	0.001855	0	14	145										A	82443993	G	A	82443993	2	1	22	1	0	0	0	0	0	0	0	1	4960	963	34	2		2	EFTUD1	15	82443993	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	7480078	82443993	20087399	296	6493										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84581959	84581959	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agactgagactgagctgcccGaggaagagtgtgaaggcccc	15	10	0	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr15:84581959G>T	uc002bjz.3	+	16	2040	c.1816G>T	c.(1816-1818)GAG>TAG	p.E606*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.E606*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.E606*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	606	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGAGCTGCCCGAGGAAGAGTG	0.637													1	0	9.16793e-09	0.00499	9.83567e-09	18	66										T	84581959	G	T	84581959	4	4	22	1	0	0	0	0	0	1	0	0	276	1059	37	3	1874	3	ADAMTSL3	15	84581959	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2137966	84581959	17949433	297	6494										
NPRL3	8131	broad.mit.edu	37	chr16	162645	162645	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agccatggcggacacctcatCctggagcgccaggatcagct	12	14	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:162645C>T	uc002cfr.2	-	6	622	c.523G>A	c.(523-525)GAT>AAT	p.D175N	NPRL3_uc010uua.1_RNA|NPRL3_uc002cfp.1_RNA|NPRL3_uc002cfq.2_5'UTR|NPRL3_uc010uub.1_Missense_Mutation_p.D150N|NPRL3_uc010uuc.1_Missense_Mutation_p.D97N|NPRL3_uc002cfs.1_Missense_Mutation_p.D150N	NM_001077350	NP_001070818	Q12980	NPRL3_HUMAN	conserved gene telomeric to alpha globin cluster	175							protein binding			ovary(1)	1						GACACCTCATCCTGGAGCGCC	0.657													0	0	0	0.001984	0	7	19										T	162645	C	T	162645	3	4	22	1	0	0	0	0	1	0	0	0	10598	855	30	1	1221	1	NPRL3	16	162645	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		162645	90192108	298	6495										
ATF7IP2	80063	broad.mit.edu	37	chr16	10566012	10566012	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tctgtggaaagtcctaatttGacaactccaattacatcaaa	5	9	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:10566012G>A	uc002czu.2	+	8	1625	c.1398G>A	c.(1396-1398)TTG>TTA	p.L466L	ATF7IP2_uc002czv.2_Silent_p.L466L|ATF7IP2_uc010uyo.1_Intron|ATF7IP2_uc010uyp.1_Silent_p.L10L|ATF7IP2_uc002czw.2_Silent_p.L466L|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	466					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GTCCTAATTTGACAACTCCAA	0.284													0	0	0	0.001368	0	11	15										A	10566012	G	A	10566012	2	1	22	1	0	0	0	0	0	0	0	1	1088	1281	45	1		1	ATF7IP2	16	10566012	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10403367	10566012	79788741	299	6496										
XYLT1	64131	broad.mit.edu	37	chr16	17232337	17232337	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggtgatgcgcaggttgttgtCcaccatggtgtcgcagtggg	17	8	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:17232337C>A	uc002dfa.2	-	8	1724	c.1639G>T	c.(1639-1641)GAC>TAC	p.D547Y		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	547	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AGGTTGTTGTCCACCATGGTG	0.597													1	0	7.93312e-07	0.00245	8.33054e-07	11	102										A	17232337	C	A	17232337	3	1	22	1	0	0	0	0	1	0	0	0	17460	855	30	3	1260	3	XYLT1	16	17232337	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6666325	17232337	73122416	300	6497										
DNAH3	55567	broad.mit.edu	37	chr16	21133386	21133386	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgacttcaagtttgatcatGattagctgaggtatgaaaaa	9	5	2	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:21133386G>A	uc010vbe.1	-	10	1464	c.1464C>T	c.(1462-1464)ATC>ATT	p.I488I	DNAH3_uc002die.2_Silent_p.I459I	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	488	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTTTGATCATGATTAGCTGAG	0.393													0	0	0	0.008361	0	31	70										A	21133386	G	A	21133386	2	1	22	1	0	0	0	0	0	0	0	1	4603	1280	45	1		1	DNAH3	16	21133386	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3901049	21133386	69221367	301	6498										
EEF2K	29904	broad.mit.edu	37	chr16	22237249	22237249	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acagcaacctaacaaaaagtGagcggtatagctccagcggg	11	10	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:22237249G>A	uc002dki.2	+	2	684	c.199G>A	c.(199-201)GAG>AAG	p.E67K	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	67					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		AACAAAAAGTGAGCGGTATAG	0.507													0	0	0	0.007291	0	28	66										A	22237249	G	A	22237249	3	1	22	1	0	0	0	0	1	0	0	0	4930	1291	45	1	201	1	EEF2K	16	22237249	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1103863	22237249	68117504	302	6499										
ZNF629	23361	broad.mit.edu	37	chr16	30795792	30795792	+	Missense_Mutation	SNP	C	C	G													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccgggccccacagcgcagtCtcgggctccatcccagagct							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30795792C>G	uc002dzs.1	-	2	220	c.12G>C	c.(10-12)GAG>GAC	p.E4D		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			ACAGCGCAGTCTCGGGCTCCA	0.632													0	0	0	0.000602	0	5	6										G	30795792	C	G	30795792	3	3	22	1	0	0	0	0	1	0	0	0	18050	912	32	1	2605	1	ZNF629	16	30795792	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	8558543	30795792	59558961	303	6500	30	2								
ZNF629	23361	broad.mit.edu	37	chr16	30795800	30795800	+	Missense_Mutation	SNP	C	C	T													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccacagcgcagtctcgggctCcatcccagagctcaggactg							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30795800C>T	uc002dzs.1	-	2	212	c.4G>A	c.(4-6)GAG>AAG	p.E2K		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	2					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GTCTCGGGCTCCATCCCAGAG	0.632													0	0	0	0.004672	0	3	6										T	30795800	C	T	30795800	3	4	22	1	0	0	0	0	1	0	0	0	18050	864	30	1	2613	1	ZNF629	16	30795800	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	8	30795800	59558953	304	6501	30	2								
ORAI3	93129	broad.mit.edu	37	chr16	30964944	30964944	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgcagcaccgtcccaagctGagccagcctgcccaccccgg	10	20	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30964944G>C	uc002eac.2	+	2	873	c.667G>C	c.(667-669)GAG>CAG	p.E223Q		NM_152288	NP_689501	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator	223						integral to membrane	protein binding				0						GTCCCAAGCTGAGCCAGCCTG	0.672											OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	34	373										C	30964944	G	C	30964944	3	2	22	1	0	0	0	0	1	0	0	0	11259	1291	45	1	673	1	ORAI3	16	30964944	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	169144	30964944	59389809	305	6502										
SETD1A	9739	broad.mit.edu	37	chr16	30990892	30990892	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctggccgacctggccctgaCccctgcccggcgcgggctgc	14	20	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:30990892C>A	uc002ead.1	+	14	4471	c.3785C>A	c.(3784-3786)ACC>AAC	p.T1262N		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1262					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CTGGCCCTGACCCCTGCCCGG	0.726													1	0	0.00621372	0.006214	0.00635361	10	36										A	30990892	C	A	30990892	3	1	22	1	0	0	0	0	1	0	0	0	14130	507	18	4	3835	4	SETD1A	16	30990892	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	25948	30990892	59363861	306	6503										
FUS	2521	broad.mit.edu	37	chr16	31195261	31195261	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagagctcccaatcgtcttaCgggcagcagtcctcctaccc	8	17	1	1	rs73530286	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:31195261C>A	uc002ebf.2	+	4	356	c.273C>A	c.(271-273)TAC>TAA	p.Y91*	FUS_uc002ebe.1_Nonsense_Mutation_p.Y91*|FUS_uc002ebh.2_Nonsense_Mutation_p.Y90*|FUS_uc002ebg.2_5'UTR|FUS_uc002ebi.2_Nonsense_Mutation_p.Y91*|FUS_uc002ebj.2_5'UTR|FUS_uc002ebk.1_5'Flank	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	91	Gln/Gly/Ser/Tyr-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		AATCGTCTTACGGGCAGCAGT	0.572			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								1	0	4.09656e-53	0.00361	4.80135e-53	133	199										A	31195261	C	A	31195261	4	1	22	1	0	0	0	0	0	1	0	0	6100	547	19	4	287	4	FUS	16	31195261	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	204369	31195261	59159492	307	6504										
RSPRY1	89970	broad.mit.edu	37	chr16	57241994	57241994	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caggaacctccctattcaatGataacattacacgaaatggc	6	11	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:57241994G>A	uc002elb.2	+	3	653	c.375G>A	c.(373-375)ATG>ATA	p.M125I	RSPRY1_uc002elc.2_Missense_Mutation_p.M125I|RSPRY1_uc002eld.2_Missense_Mutation_p.M125I	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	125						extracellular region	zinc ion binding			ovary(1)	1						CCTATTCAATGATAACATTAC	0.294													0	0	0	0.00361	0	52	110										A	57241994	G	A	57241994	3	1	22	1	0	0	0	0	1	0	0	0	13713	1290	45	1	381	1	RSPRY1	16	57241994	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	26046733	57241994	33112759	308	6505										
GPR56	9289	broad.mit.edu	37	chr16	57687989	57687989	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	accggatcaacgccacggtgTggaagctccagcccacagcc	11	16	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:57687989T>C	uc002emb.2	+	6	1004	c.712T>C	c.(712-714)TGG>CGG	p.W238R	GPR56_uc002elz.1_Missense_Mutation_p.W68R|GPR56_uc002ema.1_Missense_Mutation_p.W63R|GPR56_uc002emc.2_Missense_Mutation_p.W238R|GPR56_uc002emf.2_Missense_Mutation_p.W238R|GPR56_uc010vhs.1_Missense_Mutation_p.W238R|GPR56_uc002emd.2_Missense_Mutation_p.W238R|GPR56_uc002eme.2_Missense_Mutation_p.W238R|GPR56_uc010vht.1_Missense_Mutation_p.W243R|GPR56_uc002emg.3_Missense_Mutation_p.W238R|GPR56_uc010vhu.1_Missense_Mutation_p.W63R	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	238	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						CGCCACGGTGTGGAAGCTCCA	0.652													0	0	0	0.004007	0	14	114										C	57687989	T	C	57687989	3	2	22	1	0	0	0	0	1	0	0	0	6700	1696	59	5	741	5	GPR56	16	57687989	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	445995	57687989	32666764	309	6506										
SMPD3	55512	broad.mit.edu	37	chr16	68405651	68405651	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggcccgcgcttgggtgttaAaaaggttgttgaccctggcg	15	9	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:68405651A>T	uc002ewa.2	-	3	856	c.434T>A	c.(433-435)TTT>TAT	p.F145Y	SMPD3_uc010cfe.2_Missense_Mutation_p.F145Y|SMPD3_uc010vlh.1_Missense_Mutation_p.F145Y	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	145	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	TTGGGTGTTAAAAAGGTTGTT	0.592													0	0	0	0.006214	0	9	26										T	68405651	A	T	68405651	3	4	22	1	0	0	0	0	1	0	0	0	14806	14	1	5	1561	5	SMPD3	16	68405651	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	10717662	68405651	21949102	310	6507										
LRRC50	123872	broad.mit.edu	37	chr16	84203923	84203923	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagaggggaccctcccagctGaggccccaccaccaccgccc	10	21	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:84203923G>A	uc002fhl.3	+	8	1670	c.1489G>A	c.(1489-1491)GAG>AAG	p.E497K	LRRC50_uc010vnw.1_Missense_Mutation_p.E261K	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	497	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CCTCCCAGCTGAGGCCCCACC	0.627									Kartagener_syndrome				0	0	0	0.010818	0	32	70										A	84203923	G	A	84203923	3	1	22	1	0	0	0	0	1	0	0	0	9009	1291	45	1	1519	1	LRRC50	16	84203923	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	15798272	84203923	6150830	311	6508										
KIAA0513	9764	broad.mit.edu	37	chr16	85100858	85100858	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agaatgacatgggcgagtcgCcctcgcacccgtcctgggac	13	14	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:85100858C>T	uc002fiu.2	+	2	401	c.181C>T	c.(181-183)CCC>TCC	p.P61S	KIAA0513_uc002fis.3_Missense_Mutation_p.P61S|KIAA0513_uc010voj.1_Missense_Mutation_p.P61S|KIAA0513_uc002fit.2_Missense_Mutation_p.P61S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	61						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GGGCGAGTCGCCCTCGCACCC	0.632													0	0	0	0.001168	0	6	98										T	85100858	C	T	85100858	3	4	22	1	0	0	0	0	1	0	0	0	8181	739	26	2	183	2	KIAA0513	16	85100858	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	896935	85100858	5253895	312	6509										
KIAA0513	9764	broad.mit.edu	37	chr16	85114926	85114926	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggctctgtcttgcaggcacaCtctgaggttctggaatgcag	13	10	4	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:85114926C>G	uc002fiu.2	+	9	1128	c.908C>G	c.(907-909)ACT>AGT	p.T303S	KIAA0513_uc010voj.1_Missense_Mutation_p.T303S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	303						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		TGCAGGCACACTCTGAGGTTC	0.567													0	0	0	0.008871	0	19	22										G	85114926	C	G	85114926	3	3	22	1	0	0	0	0	1	0	0	0	8181	565	20	4	938	4	KIAA0513	16	85114926	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	14068	85114926	5239827	313	6510										
GAS8	2622	broad.mit.edu	37	chr16	90099213	90099213	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agggcactgtagtcatgaagCtggcacagaaagagcaccgc	13	10	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr16:90099213C>G	uc002fqi.1	+	4	498	c.376C>G	c.(376-378)CTG>GTG	p.L126V	GAS8_uc010vps.1_Missense_Mutation_p.L101V|GAS8_uc002fqh.2_Missense_Mutation_p.L43V|GAS8_uc010vpt.1_Missense_Mutation_p.L126V|GAS8_uc010vpu.1_Missense_Mutation_p.L43V|GAS8_uc010vpv.1_Missense_Mutation_p.L97V|GAS8_uc010cjc.1_Missense_Mutation_p.L43V|GAS8_uc010vpw.1_Missense_Mutation_p.L43V|GAS8_uc002fqj.1_5'UTR|C16orf3_uc002fqk.1_5'Flank	NM_001481	NP_001472	O95995	GAS8_HUMAN	growth arrest-specific 8	126	Microtubule-binding.				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		AGTCATGAAGCTGGCACAGAA	0.552													0	0	0	0.006214	0	9	166										G	90099213	C	G	90099213	3	3	22	1	0	0	0	0	1	0	0	0	6251	796	28	4	390	4	GAS8	16	90099213	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4984287	90099213	255540	314	6511										
SERPINF1	5176	broad.mit.edu	37	chr17	1680704	1680704	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acagacacaggggcccttctCttcattggcaagattctgga	10	11	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:1680704C>G	uc002ftl.2	+	8	1378	c.1221C>G	c.(1219-1221)CTC>CTG	p.L407L	SERPINF1_uc010cjw.2_Silent_p.L220L	NM_002615	NP_002606	P36955	PEDF_HUMAN	serine (or cysteine) proteinase inhibitor, clade	407					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity			ovary(1)	1						GGGCCCTTCTCTTCATTGGCA	0.542													0	0	0	0.009535	0	29	202										G	1680704	C	G	1680704	2	3	22	1	0	0	0	0	0	0	0	1	14114	900	32	1		1	SERPINF1	17	1680704	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		1680704	79514506	315	6512										
NEURL4	84461	broad.mit.edu	37	chr17	7222372	7222372	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctctggctcctactcaccttGagaccgttgtggaagacccc	9	15	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:7222372G>C	uc002gga.1	-	22	3688	c.3681C>G	c.(3679-3681)CTC>CTG	p.L1227L	NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Silent_p.L1225L	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1227	NHR 6.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TACTCACCTTGAGACCGTTGT	0.627													0	0	0	0.00308	0	7	64										C	7222372	G	C	7222372	2	2	22	1	0	0	0	0	0	0	0	1	10347	1277	45	1		1	NEURL4	17	7222372	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5541668	7222372	73972838	316	6513										
DNAH2	146754	broad.mit.edu	37	chr17	7637562	7637562	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctgcagaggccatgaacatGaagcctgagatggtgataaa	12	8	0	5			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:7637562G>A	uc002giu.1	+	5	704	c.690G>A	c.(688-690)ATG>ATA	p.M230I	DNAH2_uc002git.2_Missense_Mutation_p.M230I|DNAH2_uc010vuk.1_Missense_Mutation_p.M230I	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	230	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCATGAACATGAAGCCTGAGA	0.537													0	0	0	0.004482	0	7	16										A	7637562	G	A	7637562	3	1	22	1	0	0	0	0	1	0	0	0	4602	1290	45	1	708	1	DNAH2	17	7637562	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	415190	7637562	73557648	317	6514										
MYOCD	93649	broad.mit.edu	37	chr17	12656344	12656344	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agaggctgtctccagctgtcCttttgcatcccaagtacctg	9	13	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:12656344C>T	uc002gnn.2	+	10	2038	c.1739C>T	c.(1738-1740)CCT>CTT	p.P580L	MYOCD_uc002gno.2_Missense_Mutation_p.P580L|MYOCD_uc002gnp.1_Missense_Mutation_p.P484L|MYOCD_uc002gnq.2_Missense_Mutation_p.P299L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	580					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCCAGCTGTCCTTTTGCATCC	0.512													0	0	0	0.00308	0	8	122										T	12656344	C	T	12656344	3	4	22	1	0	0	0	0	1	0	0	0	10087	681	24	2	1777	2	MYOCD	17	12656344	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5018782	12656344	68538866	318	6515										
DRG2	1819	broad.mit.edu	37	chr17	17997132	17997132	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctttccatcctttagccactGagtatcatctgggcctgctg	8	13	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:17997132G>A	uc002gsh.1	+	2	125	c.70G>A	c.(70-72)GAG>AAG	p.E24K	DRG2_uc010vxg.1_Missense_Mutation_p.E24K|DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.E24K	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	24					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)					TTTAGCCACTGAGTATCATCT	0.577													0	0	0	0.002836	0	31	77										A	17997132	G	A	17997132	3	1	22	1	0	0	0	0	1	0	0	0	4762	1291	45	1	76	1	DRG2	17	17997132	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5340788	17997132	63198078	319	6516										
NOS2	4843	broad.mit.edu	37	chr17	26087165	26087165	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtggtcctcatctgggcggCggcacccaaacaccaaggtc	12	14	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:26087165C>T	uc002gzu.2	-	25	3314	c.3050G>A	c.(3049-3051)CGC>CAC	p.R1017H		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1017					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	ATCTGGGCGGCGGCACCCAAA	0.652											OREG0024268	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	104										T	26087165	C	T	26087165	3	4	22	1	0	0	0	0	1	0	0	0	10543	768	27	2	423	2	NOS2	17	26087165	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	8090033	26087165	55108045	320	6517										
NEK8	284086	broad.mit.edu	37	chr17	27064966	27064966	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggtggtccaggtggcagctgGgcgcacgcagaaagccggcg	19	11	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:27064966G>C	uc002hcp.2	+	7	1019	c.1019G>C	c.(1018-1020)GGG>GCG	p.G340A		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	340	RCC1 1.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					GTGGCAGCTGGGCGCACGCAG	0.672													0	0	0	0.010729	0	10	163										C	27064966	G	C	27064966	3	2	22	1	0	0	0	0	1	0	0	0	10330	1232	43	4	1045	4	NEK8	17	27064966	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	977801	27064966	54130244	321	6518										
EFCAB5	374786	broad.mit.edu	37	chr17	28417662	28417662	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atgaaatacttggcgagttcTctggagagataaagaaaaaa	10	4	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:28417662T>G	uc002het.2	+	20	4099	c.3907T>G	c.(3907-3909)TCT>GCT	p.S1303A	EFCAB5_uc010cse.2_Missense_Mutation_p.S1058A|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1303							calcium ion binding			ovary(1)|skin(1)	2						TGGCGAGTTCTCTGGAGAGAT	0.383													0	0	0	0.004656	0	25	94										G	28417662	T	G	28417662	3	3	22	1	0	0	0	0	1	0	0	0	4938	1551	54	5	4152	5	EFCAB5	17	28417662	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	1352696	28417662	52777548	322	6519										
AP2B1	163	broad.mit.edu	37	chr17	33977553	33977553	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttgccttttctttaggattCtgataatcctgaccttcgag	7	9	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:33977553C>A	uc002hjr.2	+	13	1730	c.1541C>A	c.(1540-1542)TCT>TAT	p.S514Y	AP2B1_uc002hjq.2_Missense_Mutation_p.S514Y|AP2B1_uc010wci.1_Missense_Mutation_p.S476Y|AP2B1_uc002hjs.2_Missense_Mutation_p.S457Y|AP2B1_uc002hjt.2_Missense_Mutation_p.S514Y|AP2B1_uc010ctv.2_Missense_Mutation_p.S514Y|AP2B1_uc010wcj.1_Missense_Mutation_p.S251Y	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	514					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTTTAGGATTCTGATAATCCT	0.438													1	0	2.14674e-31	0.00361	2.47876e-31	52	82										A	33977553	C	A	33977553	3	1	22	1	0	0	0	0	1	0	0	0	741	913	32	3	1587	3	AP2B1	17	33977553	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5559891	33977553	47217657	323	6520										
RPL23	9349	broad.mit.edu	37	chr17	37008873	37008892	+	Frame_Shift_Del	DEL	TGGTTTGCCTTTCTTGACTG	TGGTTTGCCTTTCTTGACTG	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcacccttttttctgagctcTggtttgcctttcttgactgt							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:37008873_37008892delTGGTTTGCCTTTCTTGACTG	uc002hqx.1	-	3	281_300	c.191_210delCAGTCAAGAAAGGCAAACCA	c.(190-210)ACAGTCAAGAAAGGCAAACCAfs	p.T64fs	RPL23_uc002hqw.1_Frame_Shift_Del_p.T5fs|RPL23_uc002hqy.1_Frame_Shift_Del_p.T64fs	NM_000978	NP_000969	P62829	RL23_HUMAN	ribosomal protein L23	64_70					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome				0						TTCTGAGCTCTGGTTTGCCTTTCTTGACTGTGGCCATCAC	0.482																		11	133	---	---								-	37008892	TGGTTTGCCTTTCTTGACTG	-	37008873	7	5	22	1	0	1	0	1	0	0	0	0	13570	1567	55	0	224	0	RPL23	17	37008873	Frame_Shift_Del	DEL	TGGTTTGCCTTTCTTGACTG	TCGA-BT-A42C-01A-11D-A23M-08	3031320	37008873	44186337	324	6521										
PLXDC1	57125	broad.mit.edu	37	chr17	37265201	37265201	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcagaggatgcccgtagaaaGggaaatcaaaggacaagacc	13	8	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:37265201G>C	uc002hrg.2	-	4	637	c.425C>G	c.(424-426)CCT>CGT	p.P142R	PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	142	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						CCCGTAGAAAGGGAAATCAAA	0.617													0	0	0	0.004007	0	14	29										C	37265201	G	C	37265201	3	2	22	1	0	0	0	0	1	0	0	0	12117	1000	35	4	1121	4	PLXDC1	17	37265201	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	256328	37265201	43930009	325	6522										
FKBP10	60681	broad.mit.edu	37	chr17	39977232	39977232	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gccccccaggaggcgactctCggggccaacaaggtgatcga	14	14	1	1	rs143450797	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:39977232C>T	uc002hxv.2	+	8	1615	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	FKBP10_uc002hxw.1_Silent_p.L194L	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	430	PPIase FKBP-type 4.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		AGGCGACTCTCGGGGCCAACA	0.701													0	0	0	0.009096	0	4	30										T	39977232	C	T	39977232	2	4	22	1	0	0	0	0	0	0	0	1	5902	871	31	1		1	FKBP10	17	39977232	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2712031	39977232	41217978	326	6523										
NT5C3L	115024	broad.mit.edu	37	chr17	39991455	39991455	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaagctagaatgtgacttacTgtaagaagaagggcatcgct	12	6	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:39991455T>A	uc002hyc.3	-	3	292	c.283A>T	c.(283-285)AAT>TAT	p.N95Y	NT5C3L_uc002hxx.3_5'Flank|NT5C3L_uc010wfu.1_5'Flank|NT5C3L_uc002hyb.3_Missense_Mutation_p.N18Y|NT5C3L_uc002hyd.3_Missense_Mutation_p.N18Y|NT5C3L_uc002hxy.3_Missense_Mutation_p.N53Y|NT5C3L_uc002hxz.3_Missense_Mutation_p.N18Y|NT5C3L_uc002hya.3_Missense_Mutation_p.N53Y|KLHL10_uc010cxr.2_5'Flank|KLHL10_uc010wfv.1_5'Flank|KLHL10_uc010wfw.1_5'Flank	NM_052935	NP_443167	C9JKC4	C9JKC4_HUMAN	5'-nucleotidase, cytosolic III-like	61						cytoplasm	5'-nucleotidase activity|magnesium ion binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.15)		TGTGACTTACTGTAAGAAGAA	0.388													0	0	0	0.00361	0	49	72										A	39991455	T	A	39991455	3	1	22	1	0	0	0	0	1	0	0	0	10689	1594	55	5	749	5	NT5C3L	17	39991455	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	14223	39991455	41203755	327	6524										
NBR1	4077	broad.mit.edu	37	chr17	41352619	41352619	+	Frame_Shift_Del	DEL	T	T	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agtggagcttccaccgtcacTgcccaggtaccactcacagc							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:41352619delT	uc010czd.2	+	17	2602	c.2462delT	c.(2461-2463)CTGfs	p.L821fs	NBR1_uc010diz.2_Frame_Shift_Del_p.L821fs|NBR1_uc010whu.1_Frame_Shift_Del_p.L821fs|NBR1_uc010whv.1_Frame_Shift_Del_p.L821fs|NBR1_uc010whw.1_Frame_Shift_Del_p.L800fs	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	821					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		CCACCGTCACTGCCCAGGTAC	0.517																		41	94	---	---								-	41352619	T	-	41352619	7	5	22	1	0	1	0	1	0	0	0	0	10200	1580	55	0	2524	0	NBR1	17	41352619	Frame_Shift_Del	DEL	T	TCGA-BT-A42C-01A-11D-A23M-08	1361164	41352619	39842591	328	6525										
MPP2	4355	broad.mit.edu	37	chr17	41960382	41960382	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctggggggtggtgtctcataGgtctttgaggccacagagtc	16	8	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:41960382G>C	uc010wip.1	-	5	534	c.477C>G	c.(475-477)ACC>ACG	p.T159T	MPP2_uc002ien.1_Silent_p.T131T|MPP2_uc010wim.1_Silent_p.T103T|MPP2_uc002ieo.1_Silent_p.T114T|MPP2_uc010win.1_5'UTR|MPP2_uc010wio.1_Silent_p.T103T|MPP2_uc010czm.1_Silent_p.T97T	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	138	L27 2.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GTGTCTCATAGGTCTTTGAGG	0.632													0	0	0	0.00308	0	8	98										C	41960382	G	C	41960382	2	2	22	1	0	0	0	0	0	0	0	1	9734	987	35	4		4	MPP2	17	41960382	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	607763	41960382	39234828	329	6526										
NGFR	4804	broad.mit.edu	37	chr17	47590264	47590264	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgcttgcaagctgggccaccCaggacagcgccacactggac	12	15	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:47590264C>A	uc002ioz.3	+	6	1302	c.1177C>A	c.(1177-1179)CAG>AAG	p.Q393K		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	393	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					CTGGGCCACCCAGGACAGCGC	0.692													1	0	7.07758e-08	0.004656	7.47535e-08	28	34										A	47590264	C	A	47590264	3	1	22	1	0	0	0	0	1	0	0	0	10396	595	21	4	1199	4	NGFR	17	47590264	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	5629882	47590264	33604946	330	6527										
NGFR	4804	broad.mit.edu	37	chr17	47590332	47590332	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagcgagccgacctcgtggaGagtctgtgcagtgagtccac	14	12	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:47590332G>C	uc002ioz.3	+	6	1370	c.1245G>C	c.(1243-1245)GAG>GAC	p.E415D		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	415	Cytoplasmic (Potential).|Death.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					ACCTCGTGGAGAGTCTGTGCA	0.706													0	0	0	0.010729	0	10	14										C	47590332	G	C	47590332	3	2	22	1	0	0	0	0	1	0	0	0	10396	933	33	1	1267	1	NGFR	17	47590332	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	68	47590332	33604878	331	6528										
ITGA3	3675	broad.mit.edu	37	chr17	48156573	48156573	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccatggcaatgggtcctggcCctgccgaccacctggagacc	12	16	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:48156573C>A	uc010dbl.2	+	20	2998	c.2534C>A	c.(2533-2535)CCC>CAC	p.P845H	ITGA3_uc010dbm.2_Missense_Mutation_p.P845H	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	845	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						GGGTCCTGGCCCTGCCGACCA	0.552													1	0	6.38683e-12	0.008361	7.0462e-12	28	266										A	48156573	C	A	48156573	3	1	22	1	0	0	0	0	1	0	0	0	7877	623	22	4	2612	4	ITGA3	17	48156573	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	566241	48156573	33038637	332	6529										
KIF2B	84643	broad.mit.edu	37	chr17	51900906	51900906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcggctgcagcaggagatccGagctagacgcgccctcgatg	15	13	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:51900906G>A	uc002iua.2	+	1	668	c.512G>A	c.(511-513)CGA>CAA	p.R171Q	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	171	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAGGAGATCCGAGCTAGACGC	0.532													0	0	0	0.00361	0	87	209										A	51900906	G	A	51900906	3	1	22	1	0	0	0	0	1	0	0	0	8298	1058	37	1	514	1	KIF2B	17	51900906	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3744333	51900906	29294304	333	6530										
RNF43	54894	broad.mit.edu	37	chr17	56435956	56435956	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcctggagcccggggatgtGcagctctggggaagcggtga	18	10	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:56435956G>A	uc002iwf.2	-	8	3137	c.1181C>T	c.(1180-1182)GCA>GTA	p.A394V	RNF43_uc010wnv.1_Missense_Mutation_p.A353V|RNF43_uc002iwh.3_Missense_Mutation_p.A394V|RNF43_uc002iwg.3_Missense_Mutation_p.A394V|RNF43_uc010dcw.2_Missense_Mutation_p.A267V	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	394	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGGGGATGTGCAGCTCTGGG	0.682													0	0	0	0.001168	0	6	26										A	56435956	G	A	56435956	3	1	22	1	0	0	0	0	1	0	0	0	13495	1319	46	2	1178	2	RNF43	17	56435956	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	4535050	56435956	24759254	334	6531										
BRIP1	83990	broad.mit.edu	37	chr17	59857637	59857637	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctaacctgtgaatttttaatGatatgattagcctccagctg	7	8	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:59857637G>C	uc002izk.1	-	13	2061	c.1920C>G	c.(1918-1920)ATC>ATG	p.I640M	BRIP1_uc002izl.1_Missense_Mutation_p.I21M	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	640					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						AATTTTTAATGATATGATTAG	0.333			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.001368	0	12	84										C	59857637	G	C	59857637	3	2	22	1	0	0	0	0	1	0	0	0	1514	1280	45	1	1861	1	BRIP1	17	59857637	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3421681	59857637	21337573	335	6532										
KCNH6	81033	broad.mit.edu	37	chr17	61607729	61607729	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggcaggccaggcggaccaggGccaggcacaggcaggggcaa	19	12	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:61607729G>A	uc002jay.2	+	4	581	c.501G>A	c.(499-501)GGG>GGA	p.G167G	KCNH6_uc002jax.1_Silent_p.G167G|KCNH6_uc010wpl.1_Silent_p.G44G|KCNH6_uc010wpm.1_Silent_p.G167G|KCNH6_uc002jaz.1_Silent_p.G167G	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	167	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GCGGACCAGGGCCAGGCACAG	0.637													0	0	0	0.008361	0	26	163										A	61607729	G	A	61607729	2	1	22	1	0	0	0	0	0	0	0	1	8036	1190	42	2		2	KCNH6	17	61607729	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1750092	61607729	19587481	336	6533										
LRRC37A3	374819	broad.mit.edu	37	chr17	62891163	62891163	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aggtctcctccgtggttggaGatggtttaacctctgtagta	12	8	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:62891163G>C	uc002jey.2	-	3	2744	c.2213C>G	c.(2212-2214)TCT>TGT	p.S738C	LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron|LRRC37A3_uc010dek.1_5'Flank	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	738	Extracellular (Potential).					integral to membrane					0						CGTGGTTGGAGATGGTTTAAC	0.512													0	0	0	0.00361	0	55	324										C	62891163	G	C	62891163	3	2	22	1	0	0	0	0	1	0	0	0	8993	942	33	1	2739	1	LRRC37A3	17	62891163	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1283434	62891163	18304047	337	6534										
GNA13	10672	broad.mit.edu	37	chr17	63010685	63010696	+	In_Frame_Del	DEL	ATTGTTTCAAAA	ATTGTTTCAAAA	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgaaaacccggttattgacgAttgtttcaaaaatgttcaga							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:63010685_63010696delATTGTTTCAAAA	uc002jfc.2	-	4	1022_1033	c.813_824delTTTTGAAACAAT	c.(811-825)ATTTTTGAAACAATC>ATC	p.271_275IFETI>I	GNA13_uc010wqh.1_In_Frame_Del_p.176_180IFETI>I	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	271_275					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						GTTATTGACGATTGTTTCAAAAATGTTCAGAG	0.396																		12	205	---	---								-	63010696	ATTGTTTCAAAA	-	63010685	7	5	22	1	0	1	0	1	0	0	0	0	6501	333	12	0	313	0	GNA13	17	63010685	In_Frame_Del	DEL	ATTGTTTCAAAA	TCGA-BT-A42C-01A-11D-A23M-08	119522	63010685	18184525	338	6535										
SLC25A19	60386	broad.mit.edu	37	chr17	73282503	73282503	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggaggatgccatggtactttGcgctggggtcactgcgagac	16	9	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:73282503G>C	uc002jns.3	-	2	1080	c.170C>G	c.(169-171)GCA>GGA	p.A57G	SLC25A19_uc010dge.2_Missense_Mutation_p.A57G|SLC25A19_uc002jnv.3_Missense_Mutation_p.A57G|SLC25A19_uc002jnu.3_Missense_Mutation_p.A57G|SLC25A19_uc002jnw.3_Missense_Mutation_p.A57G|SLC25A19_uc002jnt.3_Missense_Mutation_p.A57G	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	57	Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			ATGGTACTTTGCGCTGGGGTC	0.537													0	0	0	0.00245	0	15	199										C	73282503	G	C	73282503	3	2	22	1	0	0	0	0	1	0	0	0	14481	1319	46	4	812	4	SLC25A19	17	73282503	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10271818	73282503	7912707	339	6536										
CASKIN2	57513	broad.mit.edu	37	chr17	73498040	73498040	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggaaggctgctgggctcggGctggggaaggctagaagctg	20	7	0	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:73498040G>C	uc002joc.2	-	18	3665	c.3115C>G	c.(3115-3117)CCC>GCC	p.P1039A	CASKIN2_uc010wsc.1_Missense_Mutation_p.P957A	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1039	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGGGCTCGGGCTGGGGAAGG	0.697													0	0	0	0.008291	0	11	148										C	73498040	G	C	73498040	3	2	22	1	0	0	0	0	1	0	0	0	2667	1203	42	4	505	4	CASKIN2	17	73498040	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	215537	73498040	7697170	340	6537										
EXOC7	23265	broad.mit.edu	37	chr17	74097809	74097809	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggccacatggtagtagctgaTgacatggtccaggcaggaca	14	9	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:74097809T>C	uc002jqs.2	-	3	357	c.262A>G	c.(262-264)ATC>GTC	p.I88V	EXOC7_uc010dgv.1_Missense_Mutation_p.I35V|EXOC7_uc002jqq.2_Missense_Mutation_p.I88V|EXOC7_uc010wsw.1_Missense_Mutation_p.I88V|EXOC7_uc010wsx.1_Missense_Mutation_p.I88V|EXOC7_uc002jqr.2_Missense_Mutation_p.I88V|EXOC7_uc010wsv.1_Missense_Mutation_p.I47V|EXOC7_uc002jqu.2_Missense_Mutation_p.I88V|EXOC7_uc002jqv.2_Missense_Mutation_p.I88V	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	88					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			TAGTAGCTGATGACATGGTCC	0.547													0	0	0	0.002836	0	31	285										C	74097809	T	C	74097809	3	2	22	1	0	0	0	0	1	0	0	0	5310	1464	51	5	2017	5	EXOC7	17	74097809	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	599769	74097809	7097401	341	6538										
MGAT5B	146664	broad.mit.edu	37	chr17	74936492	74936492	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttgactctgcagctcttcatCgggtttggcttcccctacga	9	13	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:74936492C>T	uc002jti.2	+	12	1723	c.1620C>T	c.(1618-1620)ATC>ATT	p.I540I	MGAT5B_uc002jth.2_Silent_p.I529I	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	531	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						AGCTCTTCATCGGGTTTGGCT	0.662													0	0	0	0.00361	0	85	180										T	74936492	C	T	74936492	2	4	22	1	0	0	0	0	0	0	0	1	9549	874	31	1		1	MGAT5B	17	74936492	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	838683	74936492	6258718	342	6539										
SEC14L1	6397	broad.mit.edu	37	chr17	75189528	75189528	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccctgaaaatgaagattggaCctgttttgaacagtctgcaa	9	8	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:75189528C>T	uc002jto.2	+	6	638	c.371C>T	c.(370-372)ACC>ATC	p.T124I	SEC14L1_uc010dhc.2_Missense_Mutation_p.T124I|SEC14L1_uc010wth.1_Missense_Mutation_p.T124I|SEC14L1_uc002jtm.2_Missense_Mutation_p.T124I|SEC14L1_uc010wti.1_Missense_Mutation_p.T90I	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	124	PRELI/MSF1.				transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						GAAGATTGGACCTGTTTTGAA	0.358													0	0	0	0.001168	0	6	92										T	75189528	C	T	75189528	3	4	22	1	0	0	0	0	1	0	0	0	13981	507	18	2	385	2	SEC14L1	17	75189528	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	253036	75189528	6005682	343	6540										
CBX4	8535	broad.mit.edu	37	chr17	77808858	77808858	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	accttgcgcccacttgtcggGcgggtggctcttggccccca	13	16	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:77808858G>C	uc002jxe.2	-	5	746	c.583C>G	c.(583-585)CCC>GCC	p.P195A		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	195	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACTTGTCGGGCGGGTGGCTC	0.711											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	111										C	77808858	G	C	77808858	3	2	22	1	0	0	0	0	1	0	0	0	2720	1203	42	4	1103	4	CBX4	17	77808858	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2619330	77808858	3386352	344	6541										
CARD14	79092	broad.mit.edu	37	chr17	78162187	78162187	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	accgcacagctgtatctactGaagcaggagctgcagcgagc	12	12	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:78162187G>C	uc002jxw.1	+	5	882	c.687G>C	c.(685-687)CTG>CTC	p.L229L	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Silent_p.L229L|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_5'UTR|CARD14_uc010dhu.1_Silent_p.L27L	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	229	Potential.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGTATCTACTGAAGCAGGAGC	0.587													0	0	0	0.004289	0	36	43										C	78162187	G	C	78162187	2	2	22	1	0	0	0	0	0	0	0	1	2646	1277	45	1		1	CARD14	17	78162187	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	353329	78162187	3033023	345	6542										
SLC26A11	284129	broad.mit.edu	37	chr17	78195377	78195377	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gagatgccttcttcggtgacGgcgctgggtcaggccaggtc	16	11	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:78195377G>C	uc002jyb.1	+	3	287	c.18G>C	c.(16-18)ACG>ACC	p.T6T	SGSH_uc002jxz.3_5'Flank|SGSH_uc002jya.3_5'Flank|SGSH_uc002jxy.2_5'Flank|SGSH_uc010wue.1_5'Flank|SLC26A11_uc002jyc.1_Silent_p.T6T|SLC26A11_uc002jyd.1_Silent_p.T6T|SLC26A11_uc010dhv.1_Silent_p.T6T	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	6	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTTCGGTGACGGCGCTGGGTC	0.687													0	0	0	0.012319	0	22	20										C	78195377	G	C	78195377	2	2	22	1	0	0	0	0	0	0	0	1	14516	1103	39	4		4	SLC26A11	17	78195377	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	33190	78195377	2999833	346	6543										
CCDC57	284001	broad.mit.edu	37	chr17	80115782	80115782	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctggtccacctcacggggaaGctcacgctggagagcggccg	15	14	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr17:80115782G>A	uc002kdz.1	-	15	2438	c.2083C>T	c.(2083-2085)CTT>TTT	p.L695F	CCDC57_uc002kdx.1_Missense_Mutation_p.L695F|CCDC57_uc010dik.1_Missense_Mutation_p.L203F	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	695										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TCACGGGGAAGCTCACGCTGG	0.642													0	0	0	0.004672	0	3	18										A	80115782	G	A	80115782	3	1	22	1	0	0	0	0	1	0	0	0	2827	971	34	2	680	2	CCDC57	17	80115782	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1920405	80115782	1079428	347	6544										
EMILIN2	84034	broad.mit.edu	37	chr18	2891874	2891874	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgcgacagcctgcaccttttGaaatctctcaacgacacgat	7	14	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr18:2891874G>A	uc002kln.2	+	4	1908	c.1749G>A	c.(1747-1749)TTG>TTA	p.L583L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	583	Potential.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TGCACCTTTTGAAATCTCTCA	0.458													0	0	0	0.006122	0	16	174										A	2891874	G	A	2891874	2	1	22	1	0	0	0	0	0	0	0	1	5094	1281	45	1		1	EMILIN2	18	2891874	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08		2891874	75185374	348	6545										
LAMA1	284217	broad.mit.edu	37	chr18	6986291	6986291	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttctttcaatacctccaattCttccagcggcttctggtaat	5	12	4	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr18:6986291C>T	uc002knm.2	-	37	5318	c.5224G>A	c.(5224-5226)GAA>AAA	p.E1742K	LAMA1_uc010wzj.1_Missense_Mutation_p.E1218K	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1742	Domain II and I.|Potential.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTCCAATTCTTCCAGCGGC	0.423													0	0	0	0.009535	0	31	276										T	6986291	C	T	6986291	3	4	22	1	0	0	0	0	1	0	0	0	8605	922	32	1	4111	1	LAMA1	18	6986291	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4094417	6986291	71090957	349	6546										
ANKRD12	23253	broad.mit.edu	37	chr18	9255911	9255912	+	Missense_Mutation	DNP	TA	TA	AG													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catcacacagaaaaatgccaTaaagaaggtgagaagagcaa							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr18:9255911_9255912TA>AG	uc002knv.2	+	9	2903_2904	c.2646_2647TA>AG	c.(2644-2649)CATAAA>CAAGAA	p.882_883HK>QE	ANKRD12_uc002knw.2_Missense_Mutation_p.859_860HK>QE|ANKRD12_uc002knx.2_Missense_Mutation_p.859_860HK>QE|ANKRD12_uc010dkx.1_Missense_Mutation_p.589_590HK>QE	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	882_883						nucleus				ovary(2)|central_nervous_system(1)	3						AAAAATGCCATAAAGAAGGTGA	0.332													0	0	0	0.004672	0	5	51										AG	9255912	TA	AG	9255911	3	1	22	1	0	0	0	0	1	0	0	0	640	1403	49	5	2676	5	ANKRD12	18	9255911	Missense_Mutation	DNP	TA	TCGA-BT-A42C-01A-11D-A23M-08	2269620	9255911	68821337	350	6547										
MUM1	84939	broad.mit.edu	37	chr19	1370839	1370839	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggagtacattgtgaaggccaAgggcgcggagagccacctgc	16	10	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1370839A>G	uc010xgm.1	+	11	1817	c.1748A>G	c.(1747-1749)AAG>AGG	p.K583R	MUM1_uc010dsi.2_Missense_Mutation_p.K515R|MUM1_uc002lrz.2_Missense_Mutation_p.K584R|MUM1_uc002lsb.2_Missense_Mutation_p.K515R			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	583					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGAAGGCCAAGGGCGCGGAG	0.662													0	0	0	0.00308	0	7	7										G	1370839	A	G	1370839	3	3	22	1	0	0	0	0	1	0	0	0	9985	72	3	5	1793	5	MUM1	19	1370839	Missense_Mutation	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08		1370839	57758144	351	6548										
PCSK4	54760	broad.mit.edu	37	chr19	1482190	1482190	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagagctgtcccaggatgtaGgcggggccgtcacacgctgc	15	13	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1482190G>T	uc002ltb.1	-	15	1898	c.1836C>A	c.(1834-1836)GCC>GCA	p.A612A	C19orf25_uc010xgn.1_5'Flank|C19orf25_uc010dsk.2_5'Flank|C19orf25_uc010xgo.1_5'Flank|PCSK4_uc002lsz.2_Silent_p.A99A|PCSK4_uc002lta.2_3'UTR	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	612					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGATGTAGGCGGGGCCGT	0.716													1	0	6.4e-05	0.004672	6.62005e-05	2	3										T	1482190	G	T	1482190	2	4	22	1	0	0	0	0	0	0	0	1	11602	987	35	4		4	PCSK4	19	1482190	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	111351	1482190	57646793	352	6549										
PCSK4	54760	broad.mit.edu	37	chr19	1482922	1482922	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaaatagtagcccttgttctCtaggcccagggtccacacgc	10	13	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1482922C>G	uc002ltb.1	-	13	1731	c.1669G>C	c.(1669-1671)GAG>CAG	p.E557Q	PCSK4_uc002lsz.2_Missense_Mutation_p.E44Q|PCSK4_uc002lta.2_Intron	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	557					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTTGTTCTCTAGGCCCAGG	0.627													0	0	0	0.00499	0	16	34										G	1482922	C	G	1482922	3	3	22	1	0	0	0	0	1	0	0	0	11602	922	32	1	610	1	PCSK4	19	1482922	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	732	1482922	57646061	353	6550										
REXO1	57455	broad.mit.edu	37	chr19	1827792	1827792	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccttggtctcccgcaggccGcccccctcggcctccaggcc	10	22	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:1827792G>A	uc002lua.3	-	2	1091	c.996C>T	c.(994-996)GGC>GGT	p.G332G	REXO1_uc010dsr.1_Silent_p.G286G	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	332						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGCAGGCCGCCCCCCTCGG	0.731													0	0	0	0.006214	0	8	8										A	1827792	G	A	1827792	2	1	22	1	0	0	0	0	0	0	0	1	13241	1074	38	2		2	REXO1	19	1827792	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	344870	1827792	57301191	354	6551										
AP3D1	8943	broad.mit.edu	37	chr19	2102196	2102196	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cacttggccagcgtcgccttCatctcttctaacaagttgct	7	14	3	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:2102196C>T	uc002luz.2	-	30	3661	c.3438G>A	c.(3436-3438)ATG>ATA	p.M1146I	AP3D1_uc010dsv.2_Missense_Mutation_p.M236I|AP3D1_uc002luy.2_Missense_Mutation_p.M1105I|AP3D1_uc002lva.2_Missense_Mutation_p.M1208I	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	1146					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGTCGCCTTCATCTCTTCTA	0.572													0	0	0	0.00361	0	146	158										T	2102196	C	T	2102196	3	4	22	1	0	0	0	0	1	0	0	0	746	826	29	1	27	1	AP3D1	19	2102196	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	274404	2102196	57026787	355	6552										
ZNF555	148254	broad.mit.edu	37	chr19	2852510	2852510	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tatgaatacaacacgtacggAaaagtcttcatgcatcgccg	8	10	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:2852510A>G	uc002lwo.2	+	4	536	c.447A>G	c.(445-447)GGA>GGG	p.G149G	ZNF555_uc002lwn.3_Silent_p.G148G	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACGTACGGAAAAGTCTTCA	0.458													0	0	0	0.001368	0	11	120										G	2852510	A	G	2852510	2	3	22	1	0	0	0	0	0	0	0	1	17983	233	9	5		5	ZNF555	19	2852510	Silent	SNP	A	TCGA-BT-A42C-01A-11D-A23M-08	750314	2852510	56276473	356	6553										
PIAS4	51588	broad.mit.edu	37	chr19	4037409	4037409	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgagcgagtgtgaggacgccGacgagatcgagtacctggtg	17	8	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:4037409G>A	uc002lzg.2	+	10	1190	c.1180G>A	c.(1180-1182)GAC>AAC	p.D394N		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	394					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGGACGCCGACGAGATCGA	0.701													0	0	0	0.003163	0	14	32										A	4037409	G	A	4037409	3	1	22	1	0	0	0	0	1	0	0	0	11878	1058	37	1	1218	1	PIAS4	19	4037409	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1184899	4037409	55091574	357	6554										
MUC16	94025	broad.mit.edu	37	chr19	9021060	9021060	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggtggggctctcaccagaccCtgcaggaccctctctgtggt	13	14	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:9021060C>A	uc002mkp.2	-	19	37467	c.37263G>T	c.(37261-37263)CAG>CAT	p.Q12421H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12423	Extracellular (Potential).|SEA 3.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCACCAGACCCTGCAGGACCC	0.547													1	0	7.03913e-09	0.001368	7.59668e-09	13	183										A	9021060	C	A	9021060	3	1	22	1	0	0	0	0	1	0	0	0	9973	680	24	4	6524	4	MUC16	19	9021060	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4983651	9021060	50107923	358	6555										
TNPO2	30000	broad.mit.edu	37	chr19	12817453	12817453	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gcagctctgtcatcaggggcTtgaggtgcatgtcgggtggc	17	9	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:12817453T>C	uc002muo.2	-	13	1612	c.1427A>G	c.(1426-1428)AAG>AGG	p.K476R	TNPO2_uc002mup.2_Missense_Mutation_p.K568R|TNPO2_uc002muq.2_Missense_Mutation_p.K476R|TNPO2_uc002mur.2_Missense_Mutation_p.K476R|SNORD41_uc002mut.1_5'Flank	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	476	HEAT 8.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						CATCAGGGGCTTGAGGTGCAT	0.637													0	0	0	0.00308	0	7	77										C	12817453	T	C	12817453	3	2	22	1	0	0	0	0	1	0	0	0	16333	1609	56	5	1314	5	TNPO2	19	12817453	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	3796393	12817453	46311530	359	6556										
AKAP8L	26993	broad.mit.edu	37	chr19	15512114	15512114	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gggatgatgttctgggagaaGagggagggcagccgagaggc	21	5	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:15512114G>C	uc002naw.1	-	5	762	c.663C>G	c.(661-663)CTC>CTG	p.L221L	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Silent_p.L160L|AKAP8L_uc002nay.1_Silent_p.L221L|AKAP8L_uc002naz.2_Silent_p.L69L	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	221						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						TCTGGGAGAAGAGGGAGGGCA	0.672													0	0	0	0.00361	0	87	93										C	15512114	G	C	15512114	2	2	22	1	0	0	0	0	0	0	0	1	458	929	33	1		1	AKAP8L	19	15512114	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2694661	15512114	43616869	360	6557										
IL12RB1	3594	broad.mit.edu	37	chr19	18174753	18174753	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtgtctgctcgcacctgcacCgtgtaggctacaccagcccg	11	16	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:18174753C>T	uc002nhw.1	-	13	1615	c.1551G>A	c.(1549-1551)ACG>ACA	p.T517T	IL12RB1_uc010xqb.1_Silent_p.T517T|IL12RB1_uc002nhx.1_Silent_p.T557T	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	517	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCACCTGCACCGTGTAGGCTA	0.632													0	0	0	0.001368	0	11	21										T	18174753	C	T	18174753	2	4	22	1	0	0	0	0	0	0	0	1	7626	639	23	2		2	IL12RB1	19	18174753	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2662639	18174753	40954230	361	6558										
KIAA1683	80726	broad.mit.edu	37	chr19	18375916	18375916	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgagtggtcttccccggcaCgtgtccgtggggctgtggct	16	12	1	1	rs140540623		TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:18375916C>T	uc002nin.2	-	3	2650	c.2434G>A	c.(2434-2436)GTG>ATG	p.V812M	KIAA1683_uc010ebn.2_Missense_Mutation_p.V812M|KIAA1683_uc010xqe.1_Missense_Mutation_p.V766M	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	812						mitochondrion				ovary(2)	2						TTCCCCGGCACGTGTCCGTGG	0.687													0	0	0	0.004007	0	15	100										T	18375916	C	T	18375916	3	4	22	1	0	0	0	0	1	0	0	0	8251	536	19	2	1677	2	KIAA1683	19	18375916	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	201163	18375916	40753067	362	6559										
NCAN	1463	broad.mit.edu	37	chr19	19337300	19337300	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgctttctcccacagctcatCaccccacgtcacaacatgga	5	17	4	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:19337300C>T	uc002nlz.2	+	7	1177	c.1078C>T	c.(1078-1080)CAC>TAC	p.H360Y	NCAN_uc010ecc.1_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	360					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CACAGCTCATCACCCCACGTC	0.562													0	0	0	0.001368	0	13	110										T	19337300	C	T	19337300	3	4	22	1	0	0	0	0	1	0	0	0	10204	826	29	1	1100	1	NCAN	19	19337300	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	961384	19337300	39791683	363	6560										
ZNF93	81931	broad.mit.edu	37	chr19	20045094	20045094	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctcaacccttagtaaacatGagatcattcatactggaaag	6	10	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:20045094G>A	uc002non.2	+	4	1441	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	444	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						TAGTAAACATGAGATCATTCA	0.388													0	0	0	0.00333	0	23	41										A	20045094	G	A	20045094	3	1	22	1	0	0	0	0	1	0	0	0	18199	1291	45	1	1344	1	ZNF93	19	20045094	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	707794	20045094	39083889	364	6561										
ZNF682	91120	broad.mit.edu	37	chr19	20135146	20135146	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cagaaactcccactcctccaGagagaattctatggtcacat	6	13	2	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:20135146G>C	uc002noq.2	-	2	166	c.43C>G	c.(43-45)CTG>GTG	p.L15V	ZNF682_uc002noo.2_5'UTR|ZNF682_uc002nop.2_5'UTR|ZNF682_uc010eck.2_Intron	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						CACTCCTCCAGAGAGAATTCT	0.433													0	0	0	0.003954	0	25	58										C	20135146	G	C	20135146	3	2	22	1	0	0	0	0	1	0	0	0	18086	933	33	1	1465	1	ZNF682	19	20135146	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	90052	20135146	38993837	365	6562										
ZNF257	113835	broad.mit.edu	37	chr19	22271880	22271880	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggcaaagcctttaaccggtCttcataccttattcgacata	6	11	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:22271880C>A	uc010ecx.2	+	4	1497	c.1328C>A	c.(1327-1329)TCT>TAT	p.S443Y	ZNF257_uc010ecy.2_Missense_Mutation_p.S411Y	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	443	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTAACCGGTCTTCATACCTT	0.408													1	0	0.000219431	0.00245	0.000226068	15	22										A	22271880	C	A	22271880	3	1	22	1	0	0	0	0	1	0	0	0	17797	913	32	3	1342	3	ZNF257	19	22271880	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2136734	22271880	36857103	366	6563										
MAG	4099	broad.mit.edu	37	chr19	35793494	35793494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tcctgtccacggtcatctacGagagcgagctgcagctggag	13	12	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:35793494G>A	uc002nyy.1	+	7	1263	c.1114G>A	c.(1114-1116)GAG>AAG	p.E372K	MAG_uc002nyx.1_Missense_Mutation_p.E372K|MAG_uc010eds.1_Missense_Mutation_p.E347K|MAG_uc002nyz.1_Missense_Mutation_p.E372K	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	372	Ig-like C2-type 3.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGTCATCTACGAGAGCGAGCT	0.587													0	0	0	0.007291	0	28	137										A	35793494	G	A	35793494	3	1	22	1	0	0	0	0	1	0	0	0	9162	1059	37	1	1132	1	MAG	19	35793494	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	13521614	35793494	23335489	367	6564										
DPF1	8193	broad.mit.edu	37	chr19	38709684	38709684	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaggccaccctccttcttcaGgggtgcttcacagtctgggg	13	13	4	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:38709684G>A	uc002ohl.2	-	4	421	c.394C>T	c.(394-396)CTG>TTG	p.L132L	DPF1_uc002ohm.2_Silent_p.L132L|DPF1_uc002ohn.2_Silent_p.L50L|DPF1_uc010xtu.1_Silent_p.L106L|DPF1_uc010xtv.1_Silent_p.L106L|DPF1_uc010xtw.1_Silent_p.L106L	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	132					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCCTTCTTCAGGGGTGCTTCA	0.612													0	0	0	0.007835	0	38	270										A	38709684	G	A	38709684	2	1	22	1	0	0	0	0	0	0	0	1	4716	991	35	2		2	DPF1	19	38709684	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2916190	38709684	20419299	368	6565										
LGALS4	3960	broad.mit.edu	37	chr19	39292958	39292958	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acctagtttacgttatacctCttgcctgtgggaggcacata	9	10	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:39292958C>G	uc002ojg.2	-	8	871	c.657G>C	c.(655-657)AAG>AAC	p.K219N		NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	219	Galectin 2.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CGTTATACCTCTTGCCTGTGG	0.328													0	0	0	0.00361	0	171	121										G	39292958	C	G	39292958	3	3	22	1	0	0	0	0	1	0	0	0	8745	912	32	1	326	1	LGALS4	19	39292958	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	583274	39292958	19836025	369	6566										
CCDC97	90324	broad.mit.edu	37	chr19	41822706	41822706	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	caccctgcgtacccgcctgcGtaaccggcgctatgctgccc	10	19	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:41822706G>A	uc002oqg.2	+	2	586	c.464G>A	c.(463-465)CGT>CAT	p.R155H	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	155											0						ACCCGCCTGCGTAACCGGCGC	0.677													0	0	0	0.00361	0	44	61										A	41822706	G	A	41822706	3	1	22	1	0	0	0	0	1	0	0	0	2875	1145	40	2	470	2	CCDC97	19	41822706	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2529748	41822706	17306277	370	6567										
BCKDHA	593	broad.mit.edu	37	chr19	41930481	41930481	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gccacctgcagacctacgggGagcactacccactggatcac	10	16	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:41930481G>A	uc002oqq.2	+	9	1335	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Missense_Mutation_p.E470K|BCKDHA_uc002oqr.2_Missense_Mutation_p.E435K|BCKDHA_uc010xvz.1_Missense_Mutation_p.E439K	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	436					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						GACCTACGGGGAGCACTACCC	0.617													0	0	0	0.00874	0	38	149										A	41930481	G	A	41930481	3	1	22	1	0	0	0	0	1	0	0	0	1359	1175	41	1	1340	1	BCKDHA	19	41930481	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	107775	41930481	17198502	371	6568										
ZNF574	64763	broad.mit.edu	37	chr19	42584313	42584319	+	Frame_Shift_Del	DEL	GGGGAGC	GGGGAGC	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	accacctgcgcacacacacaGgggagcggcccttcccctgc							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:42584313_42584319delGGGGAGC	uc002osm.3	+	2	1724_1730	c.1555_1561delGGGGAGC	c.(1555-1563)GGGGAGCGGfs	p.G519fs	ZNF574_uc002osk.3_Frame_Shift_Del_p.G609fs	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	519_521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CACACACACAGGGGAGCGGCCCTTCCC	0.609																		15	786	---	---								-	42584319	GGGGAGC	-	42584313	7	5	22	1	0	1	0	1	0	0	0	0	18003	1000	35	0	1557	0	ZNF574	19	42584313	Frame_Shift_Del	DEL	GGGGAGC	TCGA-BT-A42C-01A-11D-A23M-08	653832	42584313	16544670	372	6569										
POU2F2	5452	broad.mit.edu	37	chr19	42600386	42600386	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgggtcgggcagcgtagggcGggtcacggcctggtggggtg	23	9	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:42600386G>A	uc002osp.2	-	8	578	c.511C>T	c.(511-513)CGC>TGC	p.R171C	POU2F2_uc002osn.2_Intron|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Intron|POU2F2_uc002osr.1_Missense_Mutation_p.R171C	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	171					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				AGCGTAGGGCGGGTCACGGCC	0.706													0	0	0	0.000602	0	5	23										A	42600386	G	A	42600386	3	1	22	1	0	0	0	0	1	0	0	0	12272	1131	39	2		2	POU2F2	19	42600386	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16073	42600386	16528597	373	6570										
PSG7	5676	broad.mit.edu	37	chr19	43441225	43441225	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gggaggggctgagaggggccCcatggtctctgctccctgcg	18	12	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:43441225C>A	uc002ovl.3	-	1	106	c.4G>T	c.(4-6)GGG>TGG	p.G2W	PSG3_uc002ouf.2_5'Flank|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.G2W	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	2					female pregnancy	extracellular region					0		Prostate(69;0.00682)				GAGAGGGGCCCCATGGTCTCT	0.572													1	0	2.38352e-08	0.004289	2.5322e-08	34	161										A	43441225	C	A	43441225	3	1	22	1	0	0	0	0	1	0	0	0	12660	623	22	4	1279	4	PSG7	19	43441225	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	840839	43441225	15687758	374	6571										
FBXO46	23403	broad.mit.edu	37	chr19	46216533	46216533	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catcaccagcagctgctgctGagaggagcggagccggctgg	16	12	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:46216533G>C	uc002pcy.2	-	2	346	c.221C>G	c.(220-222)TCA>TGA	p.S74*	FBXO46_uc002pcz.2_Nonsense_Mutation_p.S74*	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	74							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		AGCTGCTGCTGAGAGGAGCGG	0.642													0	0	0	0.003163	0	13	114										C	46216533	G	C	46216533	4	2	22	1	0	0	0	0	0	1	0	0	5755	1294	45	1	1594	1	FBXO46	19	46216533	Nonsense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	2775308	46216533	12912450	375	6572										
MAMSTR	284358	broad.mit.edu	37	chr19	49218558	49218558	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	agtctgtcccttcccacagaGatggcccaggaggacccagg	12	14	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:49218558G>C	uc002pkg.2	-	5	448	c.386C>G	c.(385-387)TCT>TGT	p.S129C	MAMSTR_uc002pkf.2_Missense_Mutation_p.S26C	NM_001130915	NP_001124387	Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing	129	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			ovary(1)	1						TTCCCACAGAGATGGCCCAGG	0.627													0	0	0	0.000602	0	3	9										C	49218558	G	C	49218558	3	2	22	1	0	0	0	0	1	0	0	0	9209	942	33	1	885	1	MAMSTR	19	49218558	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	3002025	49218558	9910425	376	6573										
FUT1	2523	broad.mit.edu	37	chr19	49254435	49254435	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acaggatcgacaggcctaggCcatgtggaaagctgtcttga	13	9	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:49254435C>T	uc002pkk.2	-	4	1079	c.104G>A	c.(103-105)GGC>GAC	p.G35D		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	35	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		CAGGCCTAGGCCATGTGGAAA	0.602													0	0	0	0.004656	0	23	93										T	49254435	C	T	49254435	3	4	22	1	0	0	0	0	1	0	0	0	6101	739	26	2	997	2	FUT1	19	49254435	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	35877	49254435	9874548	377	6574										
TSKS	60385	broad.mit.edu	37	chr19	50266516	50266516	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gctcgccatggtgtgggggtCtggctcccagggaggggctc	19	11	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:50266516C>T	uc002ppm.2	-	1	1	c.-10_splice	c.e1-1			NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate								protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GTGTGGGGGTCTGGCTCCCAG	0.632													0	0	0	0.00632	0	27	115										T	50266516	C	T	50266516	5	4	22	1	0	0	0	0	0	0	1	0	16623	928	32	1		1	TSKS	19	50266516	Splice_Site	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1012081	50266516	8862467	378	6575										
TMEM150B	284417	broad.mit.edu	37	chr19	55824329	55824329	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tccagggcggagaagtcaacGgctaagagaccgaagagcgc	15	10	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:55824329G>A	uc010esw.1	-	8	773	c.600C>T	c.(598-600)GCC>GCT	p.A200A	TMEM150B_uc010yfu.1_Silent_p.A200A|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	200	Helical; (Potential).					integral to membrane					0						AGAAGTCAACGGCTAAGAGAC	0.682													0	0	0	0.004672	0	3	34										A	55824329	G	A	55824329	2	1	22	1	0	0	0	0	0	0	0	1	16065	1103	39	2		2	TMEM150B	19	55824329	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	5557813	55824329	3304654	379	6576										
ZNF471	57573	broad.mit.edu	37	chr19	57037045	57037045	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ttgcccaacatcagaaaactCatacaggagagaaaccttat	6	10	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:57037045C>G	uc002qnh.2	+	5	1742	c.1609C>G	c.(1609-1611)CAT>GAT	p.H537D		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	537	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		TCAGAAAACTCATACAGGAGA	0.393													0	0	0	0.006214	0	9	93										G	57037045	C	G	57037045	3	3	22	1	0	0	0	0	1	0	0	0	17927	826	29	1	1623	1	ZNF471	19	57037045	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1212716	57037045	2091938	380	6577										
ZNF460	10794	broad.mit.edu	37	chr19	57803086	57803086	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	acactggagaaaagccttttGagtgcaaagaatgtgggaaa	12	5	0	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:57803086G>C	uc002qog.2	+	3	1499	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q	ZNF460_uc010ygv.1_Missense_Mutation_p.E352Q	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	393	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAGCCTTTTGAGTGCAAAGA	0.468													0	0	0	0.003271	0	35	133										C	57803086	G	C	57803086	3	2	22	1	0	0	0	0	1	0	0	0	17921	1291	45	1	1187	1	ZNF460	19	57803086	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	766041	57803086	1325897	381	6578										
ZNF551	90233	broad.mit.edu	37	chr19	58198132	58198132	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gaagagccctggaaaaggaaGgtggatgaggctacatttgt	15	5	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:58198132G>A	uc002qpw.3	+	3	664	c.441G>A	c.(439-441)AAG>AAA	p.K147K	ZNF551_uc002qpv.3_Silent_p.K90K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAAAAGGAAGGTGGATGAGG	0.507													0	0	0	0.00361	0	119	94										A	58198132	G	A	58198132	2	1	22	1	0	0	0	0	0	0	0	1	17980	991	35	2		2	ZNF551	19	58198132	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	395046	58198132	930851	382	6579										
ZNF274	10782	broad.mit.edu	37	chr19	58723904	58723904	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctagaaaacgattgcgcaaaCgtgactcacaagttaaaagt	8	8	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr19:58723904C>A	uc002qrq.1	+	10	1816	c.1357C>A	c.(1357-1359)CGT>AGT	p.R453S	ZNF274_uc002qrr.1_Missense_Mutation_p.R421S|ZNF274_uc002qrs.1_Missense_Mutation_p.R348S|ZNF274_uc010eum.1_Missense_Mutation_p.R212S	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	453					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		ATTGCGCAAACGTGACTCACA	0.423													1	0	4.68919e-08	0.008291	4.972e-08	11	163										A	58723904	C	A	58723904	3	1	22	1	0	0	0	0	1	0	0	0	17806	536	19	4	1382	4	ZNF274	19	58723904	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	525772	58723904	405079	383	6580										
CSNK2A1	1457	broad.mit.edu	37	chr20	469337	469337	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cttacctgcccaagatatcaTtgaaacgtggatctaattca	6	10	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:469337T>C	uc002wdw.1	-	11	1202	c.809A>G	c.(808-810)AAT>AGT	p.N270S	CSNK2A1_uc002wdx.1_Missense_Mutation_p.N270S|CSNK2A1_uc002wdy.1_Missense_Mutation_p.N134S	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	270	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CAAGATATCATTGAAACGTGG	0.358													0	0	0	0.00361	0	47	33										C	469337	T	C	469337	3	2	22	1	0	0	0	0	1	0	0	0	3957	1493	52	5	382	5	CSNK2A1	20	469337	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08		469337	62556183	384	6581										
C20orf194	25943	broad.mit.edu	37	chr20	3305600	3305600	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cccagatcccagagtttgctCtgctacctccttggcctgta	8	15	1	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:3305600C>A	uc002wii.2	-	14	1255	c.1204G>T	c.(1204-1206)GAG>TAG	p.E402*	C20orf194_uc002wij.3_Nonsense_Mutation_p.E141*|C20orf194_uc002wik.2_Nonsense_Mutation_p.E76*|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	402											0						AGAGTTTGCTCTGCTACCTCC	0.413													1	0	3.03874e-20	0.003271	3.42881e-20	36	114										A	3305600	C	A	3305600	4	1	22	1	0	0	0	0	0	1	0	0	2099	922	32	3	2425	3	C20orf194	20	3305600	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	2836263	3305600	59719920	385	6582										
PLCB4	5332	broad.mit.edu	37	chr20	9400495	9400495	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	catgaggcggcctgatcgaaCatttgaccccttctctgaaa	9	12	1	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:9400495C>T	uc002wnf.2	+	24	2193	c.2057C>T	c.(2056-2058)ACA>ATA	p.T686I	PLCB4_uc010gbw.1_Missense_Mutation_p.T686I|PLCB4_uc010gbx.2_Missense_Mutation_p.T698I|PLCB4_uc002wne.2_Missense_Mutation_p.T686I|PLCB4_uc002wnh.2_Missense_Mutation_p.T533I	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	686					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CCTGATCGAACATTTGACCCC	0.433													0	0	0	0.00333	0	23	277										T	9400495	C	T	9400495	3	4	22	1	0	0	0	0	1	0	0	0	12030	478	17	2	2183	2	PLCB4	20	9400495	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	6094895	9400495	53625025	386	6583										
ASXL1	171023	broad.mit.edu	37	chr20	31023699	31023699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ggacagatgggatggttgctCctcagagctgggtgtctcga	16	8	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:31023699C>T	uc002wxs.2	+	12	3610	c.3184C>T	c.(3184-3186)CCT>TCT	p.P1062S	ASXL1_uc010geb.2_Missense_Mutation_p.P953S	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1062					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GATGGTTGCTCCTCAGAGCTG	0.547			F|N|Mis		MDS|CMML								0	0	0	0.00361	0	93	156										T	31023699	C	T	31023699	3	4	22	1	0	0	0	0	1	0	0	0	1066	855	30	1	3240	1	ASXL1	20	31023699	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	21623204	31023699	32001821	387	6584										
EDEM2	55741	broad.mit.edu	37	chr20	33719493	33719493	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctgaagcaggatggctccttTcaccaagtactcaaagtagg	10	10	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:33719493T>A	uc002xbo.2	-	7	896	c.796A>T	c.(796-798)AAA>TAA	p.K266*	EDEM2_uc010zuv.1_Nonsense_Mutation_p.K225*|EDEM2_uc010zus.1_Nonsense_Mutation_p.K45*|EDEM2_uc002xbq.2_Nonsense_Mutation_p.K229*|EDEM2_uc010zut.1_Nonsense_Mutation_p.K225*|EDEM2_uc002xbp.2_Nonsense_Mutation_p.K114*|EDEM2_uc002xbn.2_Nonsense_Mutation_p.K114*|EDEM2_uc002xbr.2_Intron|EDEM2_uc010zuu.1_5'UTR	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	266					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			ATGGCTCCTTTCACCAAGTAC	0.527													0	0	0	0.005524	0	40	357										A	33719493	T	A	33719493	4	1	22	1	0	0	0	0	0	1	0	0	4912	1792	62	5	960	5	EDEM2	20	33719493	Nonsense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	2695794	33719493	29306027	388	6585										
L3MBTL	26013	broad.mit.edu	37	chr20	42159033	42159033	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgctggctggttcgagaagaCgggccacaagctgcagcctc	14	12	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:42159033C>A	uc010zwh.1	+	10	1146	c.1100C>A	c.(1099-1101)ACG>AAG	p.T367K	L3MBTL_uc002xkl.2_Missense_Mutation_p.T299K|L3MBTL_uc002xkm.2_Missense_Mutation_p.T299K|L3MBTL_uc010ggl.2_Missense_Mutation_p.T299K|L3MBTL_uc002xkn.1_Missense_Mutation_p.T58K|L3MBTL_uc002xko.2_5'Flank	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	299	MBT 1.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TTCGAGAAGACGGGCCACAAG	0.577													1	0	6.49762e-13	0.006122	7.19757e-13	16	220										A	42159033	C	A	42159033	3	1	22	1	0	0	0	0	1	0	0	0	8591	536	19	4	922	4	L3MBTL	20	42159033	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	8439540	42159033	20866487	389	6586										
MATN4	8785	broad.mit.edu	37	chr20	43932954	43932954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cgtgctcgtctagcgggggcGatgccatggcgcgcagggag	19	11	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:43932954G>A	uc002xnn.2	-	3	744	c.557C>T	c.(556-558)TCG>TTG	p.S186L	MATN4_uc002xno.2_Missense_Mutation_p.S186L|MATN4_uc002xnp.2_Missense_Mutation_p.S186L|MATN4_uc010zwr.1_Missense_Mutation_p.S134L|MATN4_uc002xnr.1_Missense_Mutation_p.S186L|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	186	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TAGCGGGGGCGATGCCATGGC	0.682													0	0	0	0.00361	0	49	76										A	43932954	G	A	43932954	3	1	22	1	0	0	0	0	1	0	0	0	9336	1059	37	1	1220	1	MATN4	20	43932954	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1773921	43932954	19092566	390	6587										
WFDC8	90199	broad.mit.edu	37	chr20	44181845	44181845	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tctgtctggggacaatcgatGtcactgtgacatgaaggtgg	14	7	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:44181845G>A	uc002xow.2	-	5	595	c.516C>T	c.(514-516)GAC>GAT	p.D172D	WFDC8_uc002xox.2_Silent_p.D172D	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	172	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				GACAATCGATGTCACTGTGAC	0.463													0	0	0	0.00308	0	8	132										A	44181845	G	A	44181845	2	1	22	1	0	0	0	0	0	0	0	1	17353	1368	48	2		2	WFDC8	20	44181845	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	248891	44181845	18843675	391	6588										
SLC2A10	81031	broad.mit.edu	37	chr20	45354635	45354635	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ataggcctcgtcagctttgcCgtgcccatggactcaggccc	11	15	2	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:45354635C>A	uc002xsl.2	+	2	1057	c.960C>A	c.(958-960)GCC>GCA	p.A320A		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	320	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCAGCTTTGCCGTGCCCATGG	0.657													1	0	1.10923e-09	0.00278	1.20906e-09	22	114										A	45354635	C	A	45354635	2	1	22	1	0	0	0	0	0	0	0	1	14539	639	23	4		4	SLC2A10	20	45354635	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1172790	45354635	17670885	392	6589										
SLMO2	51012	broad.mit.edu	37	chr20	57613514	57613526	+	Splice_Site	DEL	CACTTACAGACTT	CACTTACAGACTT	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tttctccgggaataaagacaCacttacagacttcacaatgg							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:57613514_57613526delCACTTACAGACTT	uc002yam.2	-	2	317	c.201_splice	c.e2+1	p.S67_splice	SLMO2_uc010zzv.1_Splice_Site_p.S67_splice	NM_016045	NP_057129	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2											skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			AATAAAGACACACTTACAGACTTCACAATGGAA	0.437																		20	200	---	---								-	57613526	CACTTACAGACTT	-	57613514	8	5	22	1	0	1	0	1	0	0	1	0	14751	493	17	0		0	SLMO2	20	57613514	Splice_Site	DEL	CACTTACAGACTT	TCGA-BT-A42C-01A-11D-A23M-08	12258879	57613514	5412006	393	6590										
ADRM1	11047	broad.mit.edu	37	chr20	60882815	60882815	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccagcccgacccagcccatcCagctgagcgacctccagagc	9	20	0	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:60882815C>T	uc002ycn.2	+	7	867	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	ADRM1_uc002yco.2_Nonsense_Mutation_p.Q263*	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	263					proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			CCAGCCCATCCAGCTGAGCGA	0.677													0	0	0	0.00308	0	7	41										T	60882815	C	T	60882815	4	4	22	1	0	0	0	0	0	1	0	0	345	595	21	2	809	2	ADRM1	20	60882815	Nonsense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	3269301	60882815	2142705	394	6591										
MYT1	4661	broad.mit.edu	37	chr20	62850332	62850332	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccatcctgaacctctccacgCgctgctgggagatgcctgag	11	15	1	3			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr20:62850332C>T	uc002yii.2	+	12	2279	c.1915C>T	c.(1915-1917)CGC>TGC	p.R639C	MYT1_uc002yih.2_Missense_Mutation_p.R341C|MYT1_uc002yij.2_Missense_Mutation_p.R298C	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	639					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CCTCTCCACGCGCTGCTGGGA	0.572													0	0	0	0.001855	0	14	127										T	62850332	C	T	62850332	3	4	22	1	0	0	0	0	1	0	0	0	10106	768	27	2	1953	2	MYT1	20	62850332	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	1967517	62850332	175188	395	6592										
N6AMT1	29104	broad.mit.edu	37	chr21	30255351	30255351	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	atagaggctaggaatgcagaTactacaccagaccctgaccc	9	12	0	4			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr21:30255351T>C	uc002ymo.1	-	2	203	c.177A>G	c.(175-177)GTA>GTG	p.V59V	N6AMT1_uc002ymp.1_Silent_p.V59V|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	59					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						GGAATGCAGATACTACACCAG	0.353													0	0	0	0.001855	0	12	86										C	30255351	T	C	30255351	2	2	22	1	0	0	0	0	0	0	0	1	10114	1393	49	5		5	N6AMT1	21	30255351	Silent	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08		30255351	17874544	396	6593										
ABCG1	9619	broad.mit.edu	37	chr21	43704774	43704774	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccaccagcccagcgccaaacTcttcgagctgttcgaccagg	9	17	1	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr21:43704774T>C	uc002zaq.2	+	7	945	c.839T>C	c.(838-840)CTC>CCC	p.L280P	ABCG1_uc002zan.2_Missense_Mutation_p.L282P|ABCG1_uc002zam.2_Missense_Mutation_p.L258P|ABCG1_uc002zao.2_Missense_Mutation_p.L277P|ABCG1_uc002zap.2_Missense_Mutation_p.L280P|ABCG1_uc002zar.2_Missense_Mutation_p.L291P|ABCG1_uc011aev.1_Missense_Mutation_p.L291P|ABCG1_uc010gpb.1_5'Flank	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	280	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	AGCGCCAAACTCTTCGAGCTG	0.627													0	0	0	0.008871	0	15	157										C	43704774	T	C	43704774	3	2	22	1	0	0	0	0	1	0	0	0	68	1551	54	5	1033	5	ABCG1	21	43704774	Missense_Mutation	SNP	T	TCGA-BT-A42C-01A-11D-A23M-08	13449423	43704774	4425121	397	6594										
PCNT	5116	broad.mit.edu	37	chr21	47858159	47858159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	cctcacaaaagcgctcagcaCggtgacccaggagaagctgg	12	13	2	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr21:47858159C>T	uc002zji.3	+	41	9289	c.9182C>T	c.(9181-9183)ACG>ATG	p.T3061M	PCNT_uc002zjj.2_Missense_Mutation_p.T2864M	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3061	Interaction with NEK2.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCGCTCAGCACGGTGACCCAG	0.512													0	0	0	0.00308	0	8	104										T	47858159	C	T	47858159	3	4	22	1	0	0	0	0	1	0	0	0	11590	536	19	2	9344	2	PCNT	21	47858159	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	4153385	47858159	271736	398	6595										
AP1B1	162	broad.mit.edu	37	chr22	29745198	29745206	+	Splice_Site	DEL	CTGGCTCAC	CTGGCTCAC	-													0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ctcacaccctggccagctcgCtggctcacctgtgtgctctc							TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr22:29745198_29745206delCTGGCTCAC	uc003afj.2	-	11	1621	c.1437_splice	c.e11+1	p.Q479_splice	AP1B1_uc003afi.2_Splice_Site_p.Q479_splice|AP1B1_uc003afk.2_Splice_Site_p.Q479_splice|AP1B1_uc003afl.2_Splice_Site_p.Q479_splice|AP1B1_uc011ako.1_Splice_Site_p.Q32_splice	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GGCCAGCTCGCTGGCTCACCTGTGTGCTC	0.584																		12	107	---	---								-	29745206	CTGGCTCAC	-	29745198	8	5	22	1	0	1	0	1	0	0	1	0	731	812	28	0		0	AP1B1	22	29745198	Splice_Site	DEL	CTGGCTCAC	TCGA-BT-A42C-01A-11D-A23M-08		29745198	21559368	399	6596										
TCN2	6948	broad.mit.edu	37	chr22	31013431	31013431	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gtccatctctgttctggccgGgtccaccgtggaagatgtcc	12	13	2	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr22:31013431G>A	uc003aip.1	+	7	1213	c.1055G>A	c.(1054-1056)GGG>GAG	p.G352E	TCN2_uc003aiq.1_Missense_Mutation_p.G348E|TCN2_uc003air.1_Missense_Mutation_p.G325E	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	352					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTCTGGCCGGGTCCACCGTG	0.572													0	0	0	0.007291	0	30	75										A	31013431	G	A	31013431	3	1	22	1	0	0	0	0	1	0	0	0	15704	1232	43	2	1081	2	TCN2	22	31013431	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	1268233	31013431	20291135	400	6597										
EFCAB6	64800	broad.mit.edu	37	chr22	43950813	43950813	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	taaactcctctctggagatgGtgttcgttttcatggtgtca	10	8	3	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chr22:43950813G>T	uc003bdy.1	-	27	3799	c.3584C>A	c.(3583-3585)ACC>AAC	p.T1195N	EFCAB6_uc003bdz.1_Missense_Mutation_p.T1043N|EFCAB6_uc010gzi.1_Missense_Mutation_p.T1043N|EFCAB6_uc010gzj.1_Missense_Mutation_p.T421N	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1195	EF-hand 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				TCTGGAGATGGTGTTCGTTTT	0.527													1	0	4.7796e-09	0.004656	5.1787e-09	26	191										T	43950813	G	T	43950813	3	4	22	1	0	0	0	0	1	0	0	0	4939	1261	44	4	945	4	EFCAB6	22	43950813	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	12937382	43950813	7353753	401	6598										
XG	7499	broad.mit.edu	37	chrX	2670373	2670373	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tgtgttttctaatgcacgccCgaggtaagaggcattttgct	11	8	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:2670373C>A	uc011mhg.1	+	1	281	c.58C>A	c.(58-60)CGA>AGA	p.R20R	XG_uc010ndb.2_RNA|XG_uc004cqp.2_Silent_p.R20R	NM_175569	NP_780778	P55808	XG_HUMAN	XG glycoprotein isoform 1 precursor	20						integral to membrane|plasma membrane				ovary(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AATGCACGCCCGAGGTAAGAG	0.483													1	0	3.17917e-66	0.00361	3.73416e-66	114	190										A	2670373	C	A	2670373	2	1	22	1	0	0	0	0	0	0	0	1	17424	644	23	4		4	XG	23	2670373	Silent	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08		2670373	152600187	402	6599										
RPGR	6103	broad.mit.edu	37	chrX	38156597	38156597	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	actctcttggaggtttctctCagaacatcgtggaaagactg	10	9	3	2			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:38156597C>T	uc004ded.1	-	11	1522	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	RPGR_uc004deb.2_Missense_Mutation_p.E452K|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA|RPGR_uc004dee.1_Missense_Mutation_p.E137K	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	452					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						AGGTTTCTCTCAGAACATCGT	0.453													0	0	0	0.010504	0	21	36										T	38156597	C	T	38156597	3	4	22	1	0	0	0	0	1	0	0	0	13548	835	29	1	2683	1	RPGR	23	38156597	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	35486224	38156597	117113963	403	6600										
SLC35A2	7355	broad.mit.edu	37	chrX	48762196	48762196	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	aggtagacagcaccaatgacGagtccagcgccaagggcaaa	12	11	0	2	rs146079657	byFrequency	TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:48762196G>A	uc004dlo.1	-	4	994	c.990C>T	c.(988-990)CTC>CTT	p.L330L	SLC35A2_uc011mml.1_Silent_p.L343L|SLC35A2_uc004dlp.1_Silent_p.L330L|SLC35A2_uc011mmm.1_Silent_p.L358L|SLC35A2_uc011mmn.1_Silent_p.L269L|SLC35A2_uc004dlr.1_Missense_Mutation_p.S184L|SLC35A2_uc004dlq.2_Intron	NM_005660	NP_005651	P78381	S35A2_HUMAN	solute carrier family 35, member A2 isoform a	330	Helical; (Potential).				galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)	1						CACCAATGACGAGTCCAGCGC	0.607													0	0	0	0.005443	0	24	5										A	48762196	G	A	48762196	2	1	22	1	0	0	0	0	0	0	0	1	14571	1045	37	1		1	SLC35A2	23	48762196	Silent	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	10605599	48762196	106508364	404	6601										
KCND1	3750	broad.mit.edu	37	chrX	48826378	48826378	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccgtgggcaatgcagccgccCcgttcggtagaagttcagca	13	13	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:48826378C>A	uc004dlx.1	-	1	1874	c.301G>T	c.(301-303)GGG>TGG	p.G101W	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	101	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						TGCAGCCGCCCCGTTCGGTAG	0.582													1	0	0.000274275	0.004482	0.000282038	8	32										A	48826378	C	A	48826378	3	1	22	1	0	0	0	0	1	0	0	0	8018	623	22	4	1666	4	KCND1	23	48826378	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	64182	48826378	106444182	405	6602										
CCDC120	90060	broad.mit.edu	37	chrX	48921477	48921477	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	ccggcggccccccacagcccGcgcctaccctccaccgcacc	8	26	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:48921477G>A	uc010nik.2	+	5	776	c.269G>A	c.(268-270)CGC>CAC	p.R90H	CCDC120_uc011mmq.1_Missense_Mutation_p.R78H|CCDC120_uc004dmf.2_Missense_Mutation_p.R90H|CCDC120_uc010nil.2_Missense_Mutation_p.R90H|CCDC120_uc011mmr.1_Missense_Mutation_p.R90H|CCDC120_uc011mms.1_Missense_Mutation_p.R78H	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	90							protein binding			pancreas(1)	1						CCCACAGCCCGCGCCTACCCT	0.682													0	0	0	0.009096	0	4	22										A	48921477	G	A	48921477	3	1	22	1	0	0	0	0	1	0	0	0	2756	1087	38	2	279	2	CCDC120	23	48921477	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	95099	48921477	106349083	406	6603										
HEPH	9843	broad.mit.edu	37	chrX	65427138	65427138	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	tggtacattcaggatccctcGgccaaggactggaccagaag	12	11	1	1			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:65427138G>A	uc011moz.1	+	14	2462	c.2402G>A	c.(2401-2403)CGG>CAG	p.R801Q	HEPH_uc004dwn.2_Missense_Mutation_p.R801Q|HEPH_uc004dwo.2_Missense_Mutation_p.R531Q|HEPH_uc010nkr.2_Missense_Mutation_p.R609Q|HEPH_uc011mpa.1_Missense_Mutation_p.R801Q|HEPH_uc010nks.2_Missense_Mutation_p.R90Q	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	798	Extracellular (Potential).|Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AGGATCCCTCGGCCAAGGACT	0.478													0	0	0	0.001855	0	14	3										A	65427138	G	A	65427138	3	1	22	1	0	0	0	0	1	0	0	0	7054	1116	39	2	2609	2	HEPH	23	65427138	Missense_Mutation	SNP	G	TCGA-BT-A42C-01A-11D-A23M-08	16505661	65427138	89843422	407	6604										
PDZD4	57595	broad.mit.edu	37	chrX	153072223	153072223	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.278325123152709	113	5.05306756356965e-29	3.09677451304061	4.33395867439494	2.36053608573159	0.612490633302584	0.730493415865467	77	gacataaatgcccaggtcctCctcgtcgtccgtgcggtagc	11	14	0	0			TCGA-BT-A42C-01A-11D-A23M-08	TCGA-BT-A42C-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ecdb39bc-f59d-4b7e-8541-985acea634f9	109c7ef3-fe4f-4d2a-8dc1-7ed3ba4735b2	g.chrX:153072223C>G	uc004fiz.1	-	4	710	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	PDZD4_uc004fiy.1_Missense_Mutation_p.E79Q|PDZD4_uc004fix.2_Missense_Mutation_p.E58Q|PDZD4_uc004fja.1_Missense_Mutation_p.E160Q|PDZD4_uc011mze.1_Missense_Mutation_p.E45Q	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	154	PDZ.					cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGGTCCTCCTCGTCGTCC	0.627													0	0	0	0.00361	0	67	16										G	153072223	C	G	153072223	3	3	22	1	0	0	0	0	1	0	0	0	11703	864	30	1	1869	1	PDZD4	23	153072223	Missense_Mutation	SNP	C	TCGA-BT-A42C-01A-11D-A23M-08	87645085	153072223	2198337	408	6605										
CCDC27	148870	broad.mit.edu	37	chr1	3672130	3672130	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ggctcagacacgaacgtggaCggtgagggagcccctagggc	17	11	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:3672130C>T	uc001akv.2	+	3	633	c.552C>T	c.(550-552)GAC>GAT	p.D184D		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	184										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CGAACGTGGACGGTGAGGGAG	0.647													0	0	0	0.012319	0	21	228										T	3672130	C	T	3672130	2	4	23	1	0	0	0	0	0	0	0	1	2801	550	19	2		2	CCDC27	1	3672130	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08		3672130	245578491	1	6606										
CAMTA1	23261	broad.mit.edu	37	chr1	7798119	7798119	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aaattgaaccctgagtacttCcagacaaggcaggagaagct	10	9	0	4			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:7798119C>G	uc001aoi.2	+	16	3966	c.3759C>G	c.(3757-3759)TTC>TTG	p.F1253L	CAMTA1_uc010nzv.1_Missense_Mutation_p.F340L|CAMTA1_uc001aok.3_Missense_Mutation_p.F296L|CAMTA1_uc001aoj.2_Missense_Mutation_p.F209L	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1253					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTGAGTACTTCCAGACAAGGC	0.488													0	0	0	0.027356	0	26	103										G	7798119	C	G	7798119	3	3	23	1	0	0	0	0	1	0	0	0	2613	854	30	1	3821	1	CAMTA1	1	7798119	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	4125989	7798119	241452502	2	6607										
PTCHD2	57540	broad.mit.edu	37	chr1	11596720	11596720	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agagcggctataagattcccCtgcccgcaggggcctcccta	11	15	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:11596720C>T	uc001ash.3	+	21	4294	c.4156C>T	c.(4156-4158)CTG>TTG	p.L1386L		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1386	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TAAGATTCCCCTGCCCGCAGG	0.672													0	0	0	0.004672	0	3	10										T	11596720	C	T	11596720	2	4	23	1	0	0	0	0	0	0	0	1	12733	680	24	2		2	PTCHD2	1	11596720	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	3798601	11596720	237653901	3	6608										
PADI4	23569	broad.mit.edu	37	chr1	17690129	17690129	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttccctgctggagccactggGcctccagtgcaccttcatca	9	16	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:17690129G>A	uc001baj.2	+	16	1899	c.1871G>A	c.(1870-1872)GGC>GAC	p.G624D		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	624					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GAGCCACTGGGCCTCCAGTGC	0.617													0	0	0	0.00308	0	7	47										A	17690129	G	A	17690129	3	1	23	1	0	0	0	0	1	0	0	0	11380	1203	42	2	1933	2	PADI4	1	17690129	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	6093409	17690129	231560492	4	6609										
LSM10	84967	broad.mit.edu	37	chr1	36859515	36859515	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	acattgcggcctgtcacaaaGaggtcatccagcttgacctg	10	12	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:36859515G>C	uc001cao.1	-	2	366	c.216C>G	c.(214-216)CTC>CTG	p.L72L		NM_032881	NP_116270	Q969L4	LSM10_HUMAN	LSM10, U7 small nuclear RNA associated	72					histone mRNA metabolic process|mRNA processing|RNA splicing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	Cajal body|U7 snRNP	histone pre-mRNA DCP binding|protein binding				0		Myeloproliferative disorder(586;0.0393)				CTGTCACAAAGAGGTCATCCA	0.552													0	0	0	0.010504	0	21	83										C	36859515	G	C	36859515	2	2	23	1	0	0	0	0	0	0	0	1	9051	929	33	1		1	LSM10	1	36859515	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	19169386	36859515	212391106	5	6610										
TTLL7	79739	broad.mit.edu	37	chr1	84373315	84373315	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgattgagcagagatggaccGagggcagctgactgaacgtc	15	8	0	5	rs143330409		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:84373315G>A	uc001djc.2	-	16	2212	c.1816C>T	c.(1816-1818)CGG>TGG	p.R606W	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	606					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GAGATGGACCGAGGGCAGCTG	0.468													0	0	0	0.021553	0	5	34										A	84373315	G	A	84373315	3	1	23	1	0	0	0	0	1	0	0	0	16729	1057	37	1	871	1	TTLL7	1	84373315	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	47513800	84373315	164877306	6	6611										
FMO3	2328	broad.mit.edu	37	chr1	171086316	171086316	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cctccttcattggggcaaagCccaacatcccatggctgttt	8	14	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:171086316C>T	uc001ghi.2	+	9	1444	c.1333C>T	c.(1333-1335)CCC>TCC	p.P445S	FMO3_uc001ghh.2_Missense_Mutation_p.P445S|FMO3_uc010pmb.1_Missense_Mutation_p.P425S|FMO3_uc010pmc.1_Missense_Mutation_p.P382S	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	445				KP -> T (in Ref. 1; AAA86284).	xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGGGCAAAGCCCAACATCCC	0.483													0	0	0	0.025465	0	39	51										T	171086316	C	T	171086316	3	4	23	1	0	0	0	0	1	0	0	0	5956	739	26	2	1363	2	FMO3	1	171086316	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	86713001	171086316	78164305	7	6612										
TNN	63923	broad.mit.edu	37	chr1	175067712	175067712	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gaccaggagagcaagaaggcCgacaccaaggcccagacagg	14	12	0	3	rs150075962	by1000genomes	TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:175067712C>T	uc001gkl.1	+	9	2213	c.2100C>T	c.(2098-2100)GCC>GCT	p.A700A	TNN_uc010pmx.1_Silent_p.A611A	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	700	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCAAGAAGGCCGACACCAAGG	0.572													0	0	0	0.015359	0	33	91										T	175067712	C	T	175067712	2	4	23	1	0	0	0	0	0	0	0	1	16320	639	23	2		2	TNN	1	175067712	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	3981396	175067712	74182909	8	6613										
LHX9	56956	broad.mit.edu	37	chr1	197881675	197881675	+	Frame_Shift_Del	DEL	C	C	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tctaagaatgctgaacggtaCcactctagaggcaggtgagt							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:197881675delC	uc001gui.1	+	1	41	c.14delC	c.(13-15)ACCfs	p.T5fs	LHX9_uc009wzc.1_RNA	NM_001014434	NP_001014434	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 2	Error:Variant_position_missing_in_Q9NQ69_after_alignment					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CTGAACGGTACCACTCTAGAG	0.567																		91	139	---	---								-	197881675	C	-	197881675	7	5	23	1	0	1	0	1	0	0	0	0	8777	507	18	0	16	0	LHX9	1	197881675	Frame_Shift_Del	DEL	C	TCGA-C4-A0F0-01A-12D-A10S-08	22813963	197881675	51368946	9	6614										
KDM5B	10765	broad.mit.edu	37	chr1	202710600	202710600	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ctgctgaatacggggccagcCctacccctaggtctatgaga	11	13	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:202710600C>T	uc001gyf.2	-	19	2956	c.2840G>A	c.(2839-2841)GGG>GAG	p.G947E	KDM5B_uc009xag.2_Missense_Mutation_p.G983E|KDM5B_uc001gyg.1_Missense_Mutation_p.G789E	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	947					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CGGGGCCAGCCCTACCCCTAG	0.547													0	0	0	0.015359	0	35	61										T	202710600	C	T	202710600	3	4	23	1	0	0	0	0	1	0	0	0	8134	623	22	2	1830	2	KDM5B	1	202710600	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	4828925	202710600	46540021	10	6615										
OR13G1	441933	broad.mit.edu	37	chr1	247835572	247835572	+	Frame_Shift_Del	DEL	G	G	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgtatagctggaagcagggcGgatataggtgtagattacag					rs117404602	by1000genomes	TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:247835572delG	uc001idi.1	-	1	772	c.772delC	c.(772-774)CGCfs	p.R258fs		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GAAGCAGGGCGGATATAGGTG	0.463																		62	70	---	---								-	247835572	G	-	247835572	7	5	23	1	0	1	0	1	0	0	0	0	10942	1116	39	0	155	0	OR13G1	1	247835572	Frame_Shift_Del	DEL	G	TCGA-C4-A0F0-01A-12D-A10S-08	45124972	247835572	1415049	11	6616										
OR2T1	26696	broad.mit.edu	37	chr1	248570286	248570286	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tctctgtgttttacaccattCtcacacccatgctgaacccc	4	16	2	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr1:248570286C>T	uc010pzm.1	+	1	991	c.991C>T	c.(991-993)CTC>TTC	p.L331F		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	331	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTACACCATTCTCACACCCAT	0.527													0	0	0	0.01441	0	60	210										T	248570286	C	T	248570286	3	4	23	1	0	0	0	0	1	0	0	0	11016	913	32	1	993	1	OR2T1	1	248570286	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	734714	248570286	680335	12	6617										
ASB3	51130	broad.mit.edu	37	chr2	53992709	53992709	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gtaagcctctgtaaaatccaTttgtttgaccagtctacaaa	6	9	2	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr2:53992709T>C	uc002rxg.1	-	2	136	c.1A>G	c.(1-3)ATG>GTG	p.M1V	ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Missense_Mutation_p.M39V|ASB3_uc010yoo.1_Missense_Mutation_p.M1V|CHAC2_uc002rxk.1_5'Flank|uc002rxj.1_5'Flank	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	1					intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTAAAATCCATTTGTTTGACC	0.443													0	0	0	0.00499	0	16	107										C	53992709	T	C	53992709	3	2	23	1	0	0	0	0	1	0	0	0	1024	1493	52	5	1591	5	ASB3	2	53992709	Missense_Mutation	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08		53992709	189206664	13	6618										
C2orf78	388960	broad.mit.edu	37	chr2	74043846	74043846	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gagcctgtttccactgctgtGaccagtctccggtcactgcc	10	15	2	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr2:74043846G>T	uc002sjr.1	+	3	2617	c.2496G>T	c.(2494-2496)GTG>GTT	p.V832V		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	832										ovary(2)	2						CCACTGCTGTGACCAGTCTCC	0.493													1	0	0.000442599	0.006214	0.000474214	9	69										T	74043846	G	T	74043846	2	4	23	1	0	0	0	0	0	0	0	1	2195	1277	45	3		3	C2orf78	2	74043846	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	20051137	74043846	169155527	14	6619										
TTN	7273	broad.mit.edu	37	chr2	179597433	179597433	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttgagccgggtttagttacaAaactgggtggttctgaagaa	13	5	1	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr2:179597433A>G	uc010zfg.1	-	53	12847	c.12623T>C	c.(12622-12624)TTT>TCT	p.F4208S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.F869S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5135							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTAGTTACAAAACTGGGTGG	0.403													0	0	0	0.008291	0	11	13										G	179597433	A	G	179597433	3	3	23	1	0	0	0	0	1	0	0	0	16732	14	1	5	88402	5	TTN	2	179597433	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	105553587	179597433	63601940	15	6620										
FAM126B	285172	broad.mit.edu	37	chr2	201846351	201846351	+	Frame_Shift_Del	DEL	G	G	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aatctacactaagatcagttGgttgctgtacatactgcttg							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr2:201846351delG	uc002uws.3	-	12	1423	c.1235delC	c.(1234-1236)CCAfs	p.P412fs	FAM126B_uc002uwu.2_Frame_Shift_Del_p.P386fs|FAM126B_uc002uwv.2_Frame_Shift_Del_p.P412fs	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	412						intracellular				ovary(1)	1						AAGATCAGTTGGTTGCTGTAC	0.478																		9	67	---	---								-	201846351	G	-	201846351	7	5	23	1	0	1	0	1	0	0	0	0	5430	1348	47	0	361	0	FAM126B	2	201846351	Frame_Shift_Del	DEL	G	TCGA-C4-A0F0-01A-12D-A10S-08	22248918	201846351	41353022	16	6621										
COL4A4	1286	broad.mit.edu	37	chr2	227953429	227953429	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tcaccttttgttccaagccaGccagggagccccaagtctcc	8	16	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr2:227953429G>T	uc010zlt.1	-	22	2217	c.1563C>A	c.(1561-1563)GGC>GGA	p.G521G		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	521	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TTCCAAGCCAGCCAGGGAGCC	0.587													1	0	9.4957e-49	0.01441	1.15488e-48	111	71										T	227953429	G	T	227953429	2	4	23	1	0	0	0	0	0	0	0	1	3693	958	34	4		4	COL4A4	2	227953429	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	26107078	227953429	15245944	17	6622										
ITGA9	3680	broad.mit.edu	37	chr3	37826549	37826549	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gggtggtggaaatagctcatGggaacccagaagaggtgacg	17	6	1	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:37826549G>C	uc003chd.2	+	26	2922	c.2869G>C	c.(2869-2871)GGG>CGG	p.G957R		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	957	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AATAGCTCATGGGAACCCAGA	0.562													0	0	0	0.014323	0	21	67										C	37826549	G	C	37826549	3	2	23	1	0	0	0	0	1	0	0	0	7883	1348	47	4	2971	4	ITGA9	3	37826549	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		37826549	160195881	18	6623										
PLXNB1	5364	broad.mit.edu	37	chr3	48453976	48453976	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	acggtgagcagagatgccacGtaggcacggtcccgagctga	15	11	0	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:48453976G>A	uc003csw.2	-	26	5178	c.4908C>T	c.(4906-4908)TAC>TAT	p.Y1636Y	PLXNB1_uc003cst.2_Silent_p.Y86Y|PLXNB1_uc003csu.2_Silent_p.Y1453Y|PLXNB1_uc003csx.2_Silent_p.Y1636Y	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1636	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAGATGCCACGTAGGCACGGT	0.572													0	0	0	0.00499	0	18	58										A	48453976	G	A	48453976	2	1	23	1	0	0	0	0	0	0	0	1	12123	1140	40	2		2	PLXNB1	3	48453976	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	10627427	48453976	149568454	19	6624										
COL7A1	1294	broad.mit.edu	37	chr3	48605196	48605196	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gcctgggggaccagcttctcCctgcaggcatcaggcagtgg	15	13	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:48605196C>A	uc003ctz.2	-	107	7931	c.7930G>T	c.(7930-7932)GGA>TGA	p.G2644*		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2644	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCAGCTTCTCCCTGCAGGCAT	0.672													1	0	5.99346e-17	0.01441	6.85692e-17	54	139										A	48605196	C	A	48605196	4	1	23	1	0	0	0	0	0	1	0	0	3704	637	22	4	952	4	COL7A1	3	48605196	Nonsense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	151220	48605196	149417234	20	6625										
LRIG1	26018	broad.mit.edu	37	chr3	66430809	66430809	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gccattggaaacaagcaagtActgggcttccgcgcgctctg	12	12	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:66430809A>G	uc003dmx.2	-	19	3174	c.3160T>C	c.(3160-3162)TAC>CAC	p.Y1054H	SLC25A26_uc011bft.1_RNA|LRIG1_uc011bfu.1_Missense_Mutation_p.Y674H|LRIG1_uc003dmw.2_Missense_Mutation_p.Y720H|LRIG1_uc010hnz.2_Missense_Mutation_p.Y770H|LRIG1_uc010hoa.2_Missense_Mutation_p.Y1031H	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	1054	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		ACAAGCAAGTACTGGGCTTCC	0.567													0	0	0	0.025465	0	38	131										G	66430809	A	G	66430809	3	3	23	1	0	0	0	0	1	0	0	0	8944	391	14	5	125	5	LRIG1	3	66430809	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	17825613	66430809	131591621	21	6626										
GPR128	84873	broad.mit.edu	37	chr3	100364943	100364943	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gcttctgttgacatggtcttTagtccaaaggtgagtttttc	10	7	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:100364943T>C	uc003duc.2	+	9	1369	c.1101T>C	c.(1099-1101)TTT>TTC	p.F367F	GPR128_uc011bhc.1_Silent_p.F68F	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	367	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						ACATGGTCTTTAGTCCAAAGG	0.378													0	0	0	0.012213	0	29	51										C	100364943	T	C	100364943	2	2	23	1	0	0	0	0	0	0	0	1	6641	1751	61	5		5	GPR128	3	100364943	Silent	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	33934134	100364943	97657487	22	6627										
STXBP5L	9515	broad.mit.edu	37	chr3	120973778	120973778	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gtacaagctaaaaacttcaaAagtgtttgaaaaacagaagg	8	5	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:120973778A>T	uc003eec.3	+	16	1618	c.1478A>T	c.(1477-1479)AAA>ATA	p.K493I	STXBP5L_uc011bji.1_Missense_Mutation_p.K493I	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	493					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AAAACTTCAAAAGTGTTTGAA	0.348													0	0	0	0.013537	0	11	21										T	120973778	A	T	120973778	3	4	23	1	0	0	0	0	1	0	0	0	15356	14	1	5	1536	5	STXBP5L	3	120973778	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	20608835	120973778	77048652	23	6628										
ACPP	55	broad.mit.edu	37	chr3	132050577	132050577	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gagtcctataaacatgaacaGgcaagttggggagccaagag	13	7	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:132050577G>A	uc010htp.2	+	3	393	c.303G>A	c.(301-303)CAG>CAA	p.Q101Q	ACPP_uc003eon.3_Silent_p.Q101Q|ACPP_uc003eop.3_Silent_p.Q101Q	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	101						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						AACATGAACAGGCAAGTTGGG	0.348													0	0	0	0.004482	0	8	21										A	132050577	G	A	132050577	2	1	23	1	0	0	0	0	0	0	0	1	167	1014	35	2		2	ACPP	3	132050577	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	11076799	132050577	65971853	24	6629										
ZNF639	51193	broad.mit.edu	37	chr3	179050893	179050893	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ctgtacttagaattctagacCacactgccttttctacaggt	6	11	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr3:179050893C>T	uc003fjq.1	+	5	629	c.286C>T	c.(286-288)CAC>TAC	p.H96Y	ZNF639_uc003fjr.1_Missense_Mutation_p.H96Y	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	96					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			aattctagaccacactgcctT	0.119													0	0	0	0.001984	0	7	13										T	179050893	C	T	179050893	3	4	23	1	0	0	0	0	1	0	0	0	18053	594	21	2	296	2	ZNF639	3	179050893	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	47000316	179050893	18971537	25	6630										
SLC4A4	8671	broad.mit.edu	37	chr4	72399971	72399971	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gtccaaaccgaggttggttcGttccaccgtttggagaaaac	11	10	0	1	rs150967020		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr4:72399971G>A	uc003hfy.2	+	18	2425	c.2308G>A	c.(2308-2310)GTT>ATT	p.V770I	SLC4A4_uc010iic.2_Missense_Mutation_p.V770I|SLC4A4_uc010iib.2_Missense_Mutation_p.V770I|SLC4A4_uc003hfz.2_Missense_Mutation_p.V770I|SLC4A4_uc003hgc.3_Missense_Mutation_p.V726I|SLC4A4_uc010iid.2_5'UTR	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	770	Interaction with CA4.|Extracellular (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AGGTTGGTTCGTTCCACCGTT	0.423													0	0	0	0.008871	0	19	32										A	72399971	G	A	72399971	3	1	23	1	0	0	0	0	1	0	0	0	14656	1145	40	2	2495	2	SLC4A4	4	72399971	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		72399971	118754305	26	6631										
INTU	27152	broad.mit.edu	37	chr4	128632073	128632073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttttttctttttaagactgaCatctggtcctgagaacacac	6	9	2	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr4:128632073C>T	uc003ifk.1	+	14	2445	c.2375C>T	c.(2374-2376)ACA>ATA	p.T792I	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	792										ovary(1)	1						TTAAGACTGACATCTGGTCCT	0.333													0	0	0	0.01441	0	48	30										T	128632073	C	T	128632073	3	4	23	1	0	0	0	0	1	0	0	0	7786	478	17	2	2429	2	INTU	4	128632073	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	56232102	128632073	62522203	27	6632										
USP38	84640	broad.mit.edu	37	chr4	144134859	144134859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agtactaacagagacccctcGtacaagtgacggtgagaaga	11	9	0	4			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr4:144134859G>A	uc003ijb.2	+	9	2264	c.1730G>A	c.(1729-1731)CGT>CAT	p.R577H	USP38_uc003ija.3_Missense_Mutation_p.R577H|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	577					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					GAGACCCCTCGTACAAGTGAC	0.413													0	0	0	0.00308	0	7	43										A	144134859	G	A	144134859	3	1	23	1	0	0	0	0	1	0	0	0	17066	1145	40	2	1764	2	USP38	4	144134859	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	15502786	144134859	47019417	28	6633										
FBXW7	55294	broad.mit.edu	37	chr4	153253770	153253770	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tcttctttgcatttctctctCcagagaaggttgtcttcagc	7	11	6	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr4:153253770C>T	uc003ims.2	-	6	1112	c.963G>A	c.(961-963)TGG>TGA	p.W321*	FBXW7_uc011cii.1_Nonsense_Mutation_p.W321*|FBXW7_uc003imt.2_Nonsense_Mutation_p.W321*|FBXW7_uc011cih.1_Nonsense_Mutation_p.W145*|FBXW7_uc003imq.2_Nonsense_Mutation_p.W241*|FBXW7_uc003imr.2_Nonsense_Mutation_p.W203*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	321	F-box.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATTTCTCTCTCCAGAGAAGGT	0.393			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.013726	0	32	19										T	153253770	C	T	153253770	4	4	23	1	0	0	0	0	0	1	0	0	5769	856	30	1	1188	1	FBXW7	4	153253770	Nonsense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	9118911	153253770	37900506	29	6634										
HCN1	348980	broad.mit.edu	37	chr5	45303773	45303773	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gacaccagcaacaccgtgttGaatgaaatacatttttttac	6	9	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr5:45303773G>A	uc003jok.2	-	6	1571	c.1546C>T	c.(1546-1548)CAA>TAA	p.Q516*		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	516	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ACACCGTGTTGAATGAAATAC	0.388													0	0	0	0.006214	0	10	116										A	45303773	G	A	45303773	4	1	23	1	0	0	0	0	0	1	0	0	6996	1299	45	1	1138	1	HCN1	5	45303773	Nonsense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		45303773	135611487	30	6635										
MAP1B	4131	broad.mit.edu	37	chr5	71494957	71494957	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agtggctactcctatgagacCattgggaaaactaccaagac	9	10	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr5:71494957C>G	uc003kbw.3	+	5	6016	c.5775C>G	c.(5773-5775)ACC>ACG	p.T1925T	MAP1B_uc010iyw.1_Silent_p.T1942T|MAP1B_uc010iyx.1_Silent_p.T1799T|MAP1B_uc010iyy.1_Silent_p.T1799T	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1925	MAP1B 3.					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CCTATGAGACCATTGGGAAAA	0.463													0	0	0	0.00308	0	8	71										G	71494957	C	G	71494957	2	3	23	1	0	0	0	0	0	0	0	1	9228	581	21	4		4	MAP1B	5	71494957	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	26191184	71494957	109420303	31	6636										
KDM3B	51780	broad.mit.edu	37	chr5	137761206	137761206	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgtagacttggtgaactgcaGgaactgtgctataatttccg	11	7	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr5:137761206G>T	uc003lcy.1	+	17	4546	c.4346G>T	c.(4345-4347)AGG>ATG	p.R1449M	KDM3B_uc010jew.1_Missense_Mutation_p.R1105M|KDM3B_uc011cys.1_Missense_Mutation_p.R481M	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1449					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GTGAACTGCAGGAACTGTGCT	0.448													1	0	1.61788e-16	0.012213	1.83541e-16	33	111										T	137761206	G	T	137761206	3	4	23	1	0	0	0	0	1	0	0	0	8127	1000	35	4	4412	4	KDM3B	5	137761206	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	66266249	137761206	43154054	32	6637										
OR10C1	442194	broad.mit.edu	37	chr6	29408490	29408490	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gatcccatctgttgcgggccGccgcaaggccttctccacct	10	17	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr6:29408490G>A	uc011dlp.1	+	1	698	c.698G>A	c.(697-699)CGC>CAC	p.R233H	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTTGCGGGCCGCCGCAAGGCC	0.587													0	0	0	0.017118	0	32	313										A	29408490	G	A	29408490	3	1	23	1	0	0	0	0	1	0	0	0	10898	1087	38	2	700	2	OR10C1	6	29408490	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		29408490	141706577	33	6638										
GPR111	222611	broad.mit.edu	37	chr6	47649716	47649716	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgaggtcctagtctggagccAagtgacaaagacagagatca	12	8	2	4			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr6:47649716A>T	uc010jzj.1	+	6	1422	c.1421A>T	c.(1420-1422)CAA>CTA	p.Q474L	GPR111_uc010jzk.1_Missense_Mutation_p.Q406L|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	474	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GTCTGGAGCCAAGTGACAAAG	0.448													0	0	0	0.01441	0	68	63										T	47649716	A	T	47649716	3	4	23	1	0	0	0	0	1	0	0	0	6628	130	5	5	1235	5	GPR111	6	47649716	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	18241226	47649716	123465351	34	6639										
AHR	196	broad.mit.edu	37	chr7	17378759	17378759	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gactaaaaatggcactagtgGaaaagactctgctaccacat	8	9	1	1	rs138430398		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:17378759G>T	uc011jxz.1	+	10	1923	c.1310G>T	c.(1309-1311)GGA>GTA	p.G437V	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	437					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					GGCACTAGTGGAAAAGACTCT	0.438													1	0	3.03874e-20	0.015359	3.53646e-20	35	65										T	17378759	G	T	17378759	3	4	23	1	0	0	0	0	1	0	0	0	416	1174	41	3	1348	3	AHR	7	17378759	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		17378759	141759904	35	6640										
PDE1C	5137	broad.mit.edu	37	chr7	31912954	31912954	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgagtagttcatagaaaataAatttcagtgcatgatcccca	7	7	2	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:31912954A>G	uc003tcm.1	-	6	1029	c.560T>C	c.(559-561)TTT>TCT	p.F187S	PDE1C_uc003tcn.1_Missense_Mutation_p.F187S|PDE1C_uc003tco.1_Missense_Mutation_p.F247S|PDE1C_uc003tcr.2_Missense_Mutation_p.F187S|PDE1C_uc003tcs.2_Missense_Mutation_p.F187S	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	187					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			ATAGAAAATAAATTTCAGTGC	0.398													0	0	0	0.007291	0	25	32										G	31912954	A	G	31912954	3	3	23	1	0	0	0	0	1	0	0	0	11635	14	1	5	1392	5	PDE1C	7	31912954	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	14534195	31912954	127225709	36	6641										
SEMA3A	10371	broad.mit.edu	37	chr7	83675657	83675657	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	taccattgagccacctggaaTcatgctgctctgtcctgatt	8	12	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:83675657T>A	uc003uhz.2	-	6	965	c.650A>T	c.(649-651)GAT>GTT	p.D217V		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	217	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						CCACCTGGAATCATGCTGCTC	0.428													0	0	0	0.008871	0	17	139										A	83675657	T	A	83675657	3	1	23	1	0	0	0	0	1	0	0	0	14024	1435	50	5	1713	5	SEMA3A	7	83675657	Missense_Mutation	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	51762703	83675657	75463006	37	6642										
ZKSCAN5	23660	broad.mit.edu	37	chr7	99117480	99117480	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tctccaagttccttcccttcCcctgaaggacagccaggagc	8	16	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:99117480C>T	uc003uqv.2	+	4	708	c.584C>T	c.(583-585)CCC>CTC	p.P195L	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.P195L|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.P195L|ZKSCAN5_uc003uqx.2_Intron|ZKSCAN5_uc003uqy.2_5'UTR	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	195					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CCTTCCCTTCCCCTGAAGGAC	0.532													0	0	0	0.012213	0	28	91										T	99117480	C	T	99117480	3	4	23	1	0	0	0	0	1	0	0	0	17687	623	22	2	594	2	ZKSCAN5	7	99117480	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	15441823	99117480	60021183	38	6643										
FBXO24	26261	broad.mit.edu	37	chr7	100189393	100189393	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	taccgccgcttcttgcccacCaaggatcacgtcttcattct	6	16	5	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:100189393C>T	uc003uvm.1	+	4	719	c.426C>T	c.(424-426)ACC>ACT	p.T142T	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Silent_p.T128T|FBXO24_uc003uvn.1_5'UTR|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Silent_p.T180T|FBXO24_uc011kka.1_Silent_p.T130T	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	142						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TCTTGCCCACCAAGGATCACG	0.607													0	0	0	0.01441	0	41	66										T	100189393	C	T	100189393	2	4	23	1	0	0	0	0	0	0	0	1	5735	581	21	2		2	FBXO24	7	100189393	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	1071913	100189393	58949270	39	6644										
RELN	5649	broad.mit.edu	37	chr7	103243875	103243875	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tctggttctcaaaatctgacAtaattgtggacggaagggca	11	7	3	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:103243875A>G	uc003vca.2	-	24	3369	c.3209T>C	c.(3208-3210)ATG>ACG	p.M1070T	RELN_uc010liz.2_Missense_Mutation_p.M1070T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1070					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAAATCTGACATAATTGTGGA	0.507													0	0	0	0.009535	0	31	93										G	103243875	A	G	103243875	3	3	23	1	0	0	0	0	1	0	0	0	13220	217	8	5	7341	5	RELN	7	103243875	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	3054482	103243875	55894788	40	6645										
RNF133	168433	broad.mit.edu	37	chr7	122338738	122338738	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgcattttggatttttccctCtggtggcactataactcctg	8	10	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr7:122338738C>G	uc003vkj.1	-	1	471	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	79	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						ATTTTTCCCTCTGGTGGCACT	0.448													0	0	0	0.019004	0	38	94										G	122338738	C	G	122338738	3	3	23	1	0	0	0	0	1	0	0	0	13439	922	32	1	899	1	RNF133	7	122338738	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	19094863	122338738	36799925	41	6646										
ANK1	286	broad.mit.edu	37	chr8	41615618	41615618	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aagctttgtccaagttacctGatcttgctgctctcagaaag	8	10	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr8:41615618G>A	uc003xok.2	-	2	149	c.65C>T	c.(64-66)TCA>TTA	p.S22L	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.S22L|ANK1_uc003xoj.2_Missense_Mutation_p.S22L|ANK1_uc003xol.2_Missense_Mutation_p.S22L|ANK1_uc003xom.2_Missense_Mutation_p.S55L	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	22	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CAAGTTACCTGATCTTGCTGC	0.507													0	0	0	0.01441	0	63	297										A	41615618	G	A	41615618	3	1	23	1	0	0	0	0	1	0	0	0	620	1294	45	1	6098	1	ANK1	8	41615618	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		41615618	104748404	42	6647										
ADCY8	114	broad.mit.edu	37	chr8	131861957	131861957	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aagttttccggaggatgaggGgcaaacatttataatcctct	10	7	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr8:131861957G>C	uc003ytd.3	-	10	2559	c.2303C>G	c.(2302-2304)CCC>CGC	p.P768R	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	768					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GAGGATGAGGGGCAAACATTT	0.473										HNSCC(32;0.087)			0	0	0	0.020292	0	15	41										C	131861957	G	C	131861957	3	2	23	1	0	0	0	0	1	0	0	0	300	1232	43	4	1488	4	ADCY8	8	131861957	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	90246339	131861957	14502065	43	6648										
ARHGAP39	80728	broad.mit.edu	37	chr8	145770746	145770746	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tggccatgagctcccagccgCgggccaggctctccaggcgg	15	16	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr8:145770746C>T	uc003zdt.1	-	7	2963	c.2408G>A	c.(2407-2409)CGC>CAC	p.R803H	ARHGAP39_uc011llk.1_Missense_Mutation_p.R803H|ARHGAP39_uc003zds.1_Missense_Mutation_p.R803H	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	803	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						CTCCCAGCCGCGGGCCAGGCT	0.662													0	0	0	0.008291	0	10	99										T	145770746	C	T	145770746	3	4	23	1	0	0	0	0	1	0	0	0	884	768	27	2	964	2	ARHGAP39	8	145770746	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	13908789	145770746	593276	44	6649										
FRMPD1	22844	broad.mit.edu	37	chr9	37746199	37746199	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cgagcccacagctgcaccacCgcacccctgtcgaggaaaag	10	17	0	0	rs147765962		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr9:37746199C>T	uc004aag.1	+	16	4214	c.4170C>T	c.(4168-4170)ACC>ACT	p.T1390T	FRMPD1_uc004aah.1_Silent_p.T1390T	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1390						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GCTGCACCACCGCACCCCTGT	0.662													0	0	0	0.01441	0	66	71										T	37746199	C	T	37746199	2	4	23	1	0	0	0	0	0	0	0	1	6057	639	23	2		2	FRMPD1	9	37746199	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08		37746199	103467232	45	6650										
C9orf41	138199	broad.mit.edu	37	chr9	77642968	77642968	+	Missense_Mutation	SNP	C	C	T													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aatgatcttccagaagtgctCacgctcaagcctctcctcct							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr9:77642968C>T	uc004ajq.2	-	1	343	c.190G>A	c.(190-192)GAG>AAG	p.E64K	C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	64										ovary(1)|skin(1)	2						CAGAAGTGCTCACGCTCAAGC	0.557													0	0	0	0.009096	0	4	10										T	77642968	C	T	77642968	3	4	23	1	0	0	0	0	1	0	0	0	2482	835	29	1	1071	1	C9orf41	9	77642968	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	39896769	77642968	63570463	46	6651	31	2								
C9orf41	138199	broad.mit.edu	37	chr9	77642970	77642970	+	Missense_Mutation	SNP	C	C	T													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgatcttccagaagtgctcaCgctcaagcctctcctcctcc							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr9:77642970C>T	uc004ajq.2	-	1	341	c.188G>A	c.(187-189)CGT>CAT	p.R63H	C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	63										ovary(1)|skin(1)	2						GAAGTGCTCACGCTCAAGCCT	0.557													0	0	0	0.009096	0	4	10										T	77642970	C	T	77642970	3	4	23	1	0	0	0	0	1	0	0	0	2482	536	19	2	1073	2	C9orf41	9	77642970	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	2	77642970	63570461	47	6652	31	2								
GCNT1	2650	broad.mit.edu	37	chr9	79118499	79118499	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	acaccacttgtttgccaataAgtttgacgtggatgttgacc	9	9	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr9:79118499A>C	uc010mpf.2	+	3	1543	c.1202A>C	c.(1201-1203)AAG>ACG	p.K401T	GCNT1_uc010mpg.2_Missense_Mutation_p.K401T|GCNT1_uc010mph.2_Missense_Mutation_p.K401T|GCNT1_uc004akf.3_Missense_Mutation_p.K401T|GCNT1_uc010mpi.2_Missense_Mutation_p.K401T|GCNT1_uc004akh.3_Missense_Mutation_p.K401T	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	401	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						TTTGCCAATAAGTTTGACGTG	0.488													0	0	0	0.007413	0	19	142										C	79118499	A	C	79118499	3	2	23	1	0	0	0	0	1	0	0	0	6300	72	3	5	1204	5	GCNT1	9	79118499	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	1475529	79118499	62094932	48	6653										
AGTPBP1	23287	broad.mit.edu	37	chr9	88272367	88272367	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cacttgcgaagtattatacaGaattttcatcccattggcat	6	9	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr9:88272367G>A	uc011ltd.1	-	9	925	c.892C>T	c.(892-894)CTG>TTG	p.L298L	AGTPBP1_uc011ltc.1_Silent_p.L196L|AGTPBP1_uc010mqc.2_Silent_p.L298L|AGTPBP1_uc011lte.1_Silent_p.L350L	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	298					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GTATTATACAGAATTTTCATC	0.289													0	0	0	0.00308	0	7	52										A	88272367	G	A	88272367	2	1	23	1	0	0	0	0	0	0	0	1	400	933	33	1		1	AGTPBP1	9	88272367	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	9153868	88272367	52941064	49	6654										
CDK20	23552	broad.mit.edu	37	chr9	90584799	90584799	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgcccgggaaaaggggggacCcattcaacagctcccccatg	12	14	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr9:90584799C>A	uc004apr.2	-	6	905	c.599G>T	c.(598-600)GGG>GTG	p.G200V	CDK20_uc004aps.2_Missense_Mutation_p.G179V|CDK20_uc004apt.2_Missense_Mutation_p.G192V|CDK20_uc004apu.2_Intron	NM_001039803	NP_001034892	Q8IZL9	CDK20_HUMAN	cell cycle related kinase isoform 3	200	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						AAGGGGGGACCCATTCAACAG	0.577													1	0	4.88506e-25	0.01441	5.78493e-25	60	103										A	90584799	C	A	90584799	3	1	23	1	0	0	0	0	1	0	0	0	3137	623	22	4	453	4	CDK20	9	90584799	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	2312432	90584799	50628632	50	6655										
FAM21A	387680	broad.mit.edu	37	chr10	51855357	51855359	+	Splice_Site	DEL	AGG	AGG	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgtcttgtctttccacccacAggagacacggatgtgtttgg							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr10:51855357_51855359delAGG	uc001jjb.2	+	15	1323	c.1241_splice	c.e15-1	p.G414_splice	FAM21A_uc001jja.1_Splice_Site_p.G166_splice|FAM21A_uc010qhi.1_Splice_Site_p.G414_splice|FAM21A_uc010qhj.1_Splice_Site_p.G414_splice|FAM21B_uc009xoq.2_Splice_Site_p.G326_splice	NM_001005751	NP_001005751	Q641Q2	FA21A_HUMAN	hypothetical protein LOC387680						retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				ovary(1)	1						TTCCACCCACAGGAGACACGGAT	0.512																		17	38	---	---								-	51855359	AGG	-	51855357	8	5	23	1	0	1	0	1	0	0	1	0	5540	202	7	0	1297	0	FAM21A	10	51855357	Splice_Site	DEL	AGG	TCGA-C4-A0F0-01A-12D-A10S-08		51855357	83679390	51	6656										
INPP5F	22876	broad.mit.edu	37	chr10	121557048	121557048	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ggagactgagcagttgattcAtgttcataatcataccctgt	9	8	3	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr10:121557048A>G	uc001leo.2	+	8	1110	c.944A>G	c.(943-945)CAT>CGT	p.H315R		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	315	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CAGTTGATTCATGTTCATAAT	0.423													0	0	0	0.020292	0	12	16										G	121557048	A	G	121557048	3	3	23	1	0	0	0	0	1	0	0	0	7758	217	8	5	974	5	INPP5F	10	121557048	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	69701691	121557048	13977699	52	6657										
OR52K1	390036	broad.mit.edu	37	chr11	4510227	4510227	+	Frame_Shift_Del	DEL	T	T	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	atgcctggatctccatccccTtctgctttgcttatactctg							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr11:4510227delT	uc001lza.1	+	1	97	c.97delT	c.(97-99)TTCfs	p.F33fs		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTCCATCCCCTTCTGCTTTGC	0.498																		99	63	---	---								-	4510227	T	-	4510227	7	5	23	1	0	1	0	1	0	0	0	0	11123	1609	56	0	99	0	OR52K1	11	4510227	Frame_Shift_Del	DEL	T	TCGA-C4-A0F0-01A-12D-A10S-08		4510227	130496289	53	6658										
OR2AG2	338755	broad.mit.edu	37	chr11	6789447	6789447	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agctccatagaacatcccgaCcacaatcaggtgggaagagc	10	12	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr11:6789447C>T	uc001meq.1	-	1	742	c.742G>A	c.(742-744)GTC>ATC	p.V248I		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AACATCCCGACCACAATCAGG	0.483													0	0	0	0.012319	0	23	17										T	6789447	C	T	6789447	3	4	23	1	0	0	0	0	1	0	0	0	10985	507	18	2	212	2	OR2AG2	11	6789447	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	2279220	6789447	128217069	54	6659										
OR5D18	219438	broad.mit.edu	37	chr11	55587220	55587220	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttctggccatctacaatgtcActgtgctagggaatattggg	11	8	3	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr11:55587220A>T	uc010rin.1	+	1	115	c.115A>T	c.(115-117)ACT>TCT	p.T39S		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				CTACAATGTCACTGTGCTAGG	0.453													0	0	0	0.01441	0	102	101										T	55587220	A	T	55587220	3	4	23	1	0	0	0	0	1	0	0	0	11157	159	6	5	117	5	OR5D18	11	55587220	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	48797773	55587220	79419296	55	6660										
TMEM123	114908	broad.mit.edu	37	chr11	102272686	102272686	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agatgtcactgaactattgtGggttacggtcattgtggatg	13	5	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr11:102272686G>A	uc001pha.2	-	3	830	c.409C>T	c.(409-411)CAC>TAC	p.H137Y	TMEM123_uc009yxc.2_Missense_Mutation_p.H118Y	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	137	Thr-rich.|Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		GAACTATTGTGGGTTACGGTC	0.373													0	0	0	0.01441	0	939	45										A	102272686	G	A	102272686	3	1	23	1	0	0	0	0	1	0	0	0	16033	1348	47	2	229	2	TMEM123	11	102272686	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	46685466	102272686	32733830	56	6661										
USP5	8078	broad.mit.edu	37	chr12	6973255	6973287	+	In_Frame_Del	DEL	GGCTCCACAAGCGCAGCAGCCGACCCCCCTCCT	GGCTCCACAAGCGCAGCAGCCGACCCCCCTCCT	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgcctggctctagtgggccgGgctccacaagcgcagcagcc							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:6973255_6973287delGGCTCCACAAGCGCAGCAGCCGACCCCCCTCCT	uc001qri.3	+	17	2199_2231	c.2140_2172delGGCTCCACAAGCGCAGCAGCCGACCCCCCTCCT	c.(2140-2172)GGCTCCACAAGCGCAGCAGCCGACCCCCCTCCTdel	p.GSTSAAADPPP714del	USP5_uc001qrh.3_In_Frame_Del_p.GSTSAAADPPP691del	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	714_724	UBA 2.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding	p.D698N(1)		lung(2)|breast(1)|skin(1)	4						TAGTGGGCCGGGCTCCACAAGCGCAGCAGCCGACCCCCCTCCTGAGGACTGTG	0.635																		7	188	---	---								-	6973287	GGCTCCACAAGCGCAGCAGCCGACCCCCCTCCT	-	6973255	7	5	23	1	0	1	0	1	0	0	0	0	17078	1232	43	0	2206	0	USP5	12	6973255	In_Frame_Del	DEL	GGCTCCACAAGCGCAGCAGCCGACCCCCCTCCT	TCGA-C4-A0F0-01A-12D-A10S-08		6973255	126878640	57	6662										
CD163	9332	broad.mit.edu	37	chr12	7656275	7656275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tcttcaagtagcaccattctGagtttgctcattccaaagat	6	10	4	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:7656275G>A	uc001qsz.3	-	1	140	c.12C>T	c.(10-12)CTC>CTT	p.L4L	CD163_uc001qta.3_Silent_p.L4L|CD163_uc009zfw.2_Silent_p.L4L	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	4					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GCACCATTCTGAGTTTGCTCA	0.318													0	0	0	0.013537	0	10	68										A	7656275	G	A	7656275	2	1	23	1	0	0	0	0	0	0	0	1	2967	1277	45	1		1	CD163	12	7656275	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	683020	7656275	126195620	58	6663										
ABCC9	10060	broad.mit.edu	37	chr12	21997778	21997778	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gtgagacccatccattctacAgtgagggatgtaacaaggca	11	9	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:21997778A>G	uc001rfi.1	-	25	3188	c.3168T>C	c.(3166-3168)ACT>ACC	p.T1056T	ABCC9_uc001rfh.2_Silent_p.T1056T|ABCC9_uc001rfj.1_Silent_p.T1020T	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1056	ABC transmembrane type-1 2.|Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCCATTCTACAGTGAGGGATG	0.418													0	0	0	0.01441	0	53	69										G	21997778	A	G	21997778	2	3	23	1	0	0	0	0	0	0	0	1	59	175	7	5		5	ABCC9	12	21997778	Silent	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	14341503	21997778	111854117	59	6664										
CAPRIN2	65981	broad.mit.edu	37	chr12	30873763	30873763	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	acctcaggagtctctgaggtCataaactctgtttcagatcc	8	11	5	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:30873763C>A	uc001rji.1	-	12	2881	c.2130G>T	c.(2128-2130)ATG>ATT	p.M710I	CAPRIN2_uc001rjf.1_Missense_Mutation_p.M507I|CAPRIN2_uc001rjg.1_Missense_Mutation_p.M377I|CAPRIN2_uc001rjh.1_Missense_Mutation_p.M710I|CAPRIN2_uc001rjj.1_Missense_Mutation_p.M377I|CAPRIN2_uc001rjk.3_Missense_Mutation_p.M710I|CAPRIN2_uc001rjl.3_Intron|CAPRIN2_uc001rjm.1_Intron	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	710					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TCTCTGAGGTCATAAACTCTG	0.378													1	0	6.97489e-18	0.021022	8.04795e-18	36	118										A	30873763	C	A	30873763	3	1	23	1	0	0	0	0	1	0	0	0	2636	826	29	3	1281	3	CAPRIN2	12	30873763	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	8875985	30873763	102978132	60	6665										
SLC2A13	114134	broad.mit.edu	37	chr12	40499322	40499322	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgacaccaccccggtgtcatAgccaaacaggaagccgccca	9	16	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:40499322A>C	uc010skm.1	-	1	340	c.289T>G	c.(289-291)TAT>GAT	p.Y97D	SLC2A13_uc001rmf.2_Missense_Mutation_p.Y97D	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	97	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				CCGGTGTCATAGCCAAACAGG	0.592										HNSCC(50;0.14)			0	0	0	0.004482	0	6	3										C	40499322	A	C	40499322	3	2	23	1	0	0	0	0	1	0	0	0	14542	420	15	5	1697	5	SLC2A13	12	40499322	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	9625559	40499322	93352573	61	6666										
CNTN1	1272	broad.mit.edu	37	chr12	41421677	41421677	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agctcctagccagcctccaaGgatcatcagttcagtaaggt	9	12	3	0	rs143121881		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:41421677G>A	uc001rmm.1	+	22	2842	c.2729G>A	c.(2728-2730)AGG>AAG	p.R910K	CNTN1_uc001rmn.1_Missense_Mutation_p.R899K	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	910	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CAGCCTCCAAGGATCATCAGT	0.393													0	0	0	0.01441	0	49	26										A	41421677	G	A	41421677	3	1	23	1	0	0	0	0	1	0	0	0	3640	1000	35	2	2811	2	CNTN1	12	41421677	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	922355	41421677	92430218	62	6667										
ACVRL1	94	broad.mit.edu	37	chr12	52307405	52307405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tggccctgatcctgggccccGtgctggccttgctggccctg	14	16	0	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:52307405G>A	uc001rzj.2	+	4	659	c.376G>A	c.(376-378)GTG>ATG	p.V126M	ACVRL1_uc001rzk.2_Missense_Mutation_p.V126M|ACVRL1_uc010snm.1_Intron	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	126	Helical; (Potential).				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CCTGGGCCCCGTGCTGGCCTT	0.682									Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.027356	0	24	10										A	52307405	G	A	52307405	3	1	23	1	0	0	0	0	1	0	0	0	225	1145	40	2	386	2	ACVRL1	12	52307405	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	10885728	52307405	81544490	63	6668										
ATP5B	506	broad.mit.edu	37	chr12	57039660	57039660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agcggcccgcagtaagagctGagctgggggcagcgacgctg	18	11	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:57039660G>C	uc001slr.2	-	1	193	c.88C>G	c.(88-90)CAG>GAG	p.Q30E	SNORD59B_uc001sls.1_5'Flank|SNORD59A_uc001slt.1_5'Flank	NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	30					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						AGTAAGAGCTGAGCTGGGGGC	0.657													0	0	0	0.004672	0	3	13										C	57039660	G	C	57039660	3	2	23	1	0	0	0	0	1	0	0	0	1148	1299	45	1	1541	1	ATP5B	12	57039660	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	4732255	57039660	76812235	64	6669										
AVPR1A	552	broad.mit.edu	37	chr12	63543915	63543926	+	In_Frame_Del	DEL	GGTACCCAAGAT	GGTACCCAAGAT	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tagcagatgaagccgtagcaGgtacccaagatgaccacggg							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:63543915_63543926delGGTACCCAAGAT	uc001sro.1	-	1	2665_2676	c.691_702delATCTTGGGTACC	c.(691-702)ATCTTGGGTACCdel	p.ILGT231del		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	231_234	Helical; Name=5; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	AGCCGTAGCAGGTACCCAAGATGACCACGGGC	0.632																		36	74	---	---								-	63543926	GGTACCCAAGAT	-	63543915	7	5	23	1	0	1	0	1	0	0	0	0	1231	987	35	0	562	0	AVPR1A	12	63543915	In_Frame_Del	DEL	GGTACCCAAGAT	TCGA-C4-A0F0-01A-12D-A10S-08	6504255	63543915	70307980	65	6670										
VPS33A	65082	broad.mit.edu	37	chr12	122745915	122745919	+	Frame_Shift_Del	DEL	TCAAC	TCAAC	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tcccaagacacccagatcctTcaaccgctgttcgcacaaca							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr12:122745915_122745919delTCAAC	uc001ucd.2	-	4	485_489	c.372_376delGTTGA	c.(370-378)CGGTTGAAGfs	p.R124fs	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Frame_Shift_Del_p.R124fs	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	124_126					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CCCAGATCCTTCAACCGCTGTTCGC	0.473																		55	131	---	---								-	122745919	TCAAC	-	122745915	7	5	23	1	0	1	0	1	0	0	0	0	17198	1792	62	0	1454	0	VPS33A	12	122745915	Frame_Shift_Del	DEL	TCAAC	TCGA-C4-A0F0-01A-12D-A10S-08	59202000	122745915	11105980	66	6671										
RB1	5925	broad.mit.edu	37	chr13	48947629	48947629	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	atctgatttcctattttaacGtaagccatatatgaaacatt	4	7	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr13:48947629G>T	uc001vcb.2	+	12	1381	c.1215_splice	c.e12+1	p.N405_splice	RB1_uc010act.1_Splice_Site_p.N106_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(14)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.264		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			1	0	1.17004e-41	0.01441	1.41032e-41	66	54										T	48947629	G	T	48947629	5	4	23	1	0	0	0	0	0	0	1	0	13098	1159	40	4	1262	4	RB1	13	48947629	Splice_Site	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		48947629	66222249	67	6672										
NEK3	4752	broad.mit.edu	37	chr13	52707832	52707832	+	Frame_Shift_Del	DEL	C	C	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tatcacaacgtacgtgtcctCctcatctagcccaggctcaa					rs34488913	by1000genomes	TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr13:52707832delC	uc001vgi.2	-	17	1664	c.1429delG	c.(1429-1431)GAGfs	p.E477fs	NEK3_uc001vgg.2_Frame_Shift_Del_p.E454fs|NEK3_uc001vgh.2_Frame_Shift_Del_p.E481fs|NEK3_uc010tgx.1_RNA|NEK3_uc010tgy.1_Frame_Shift_Del_p.E460fs	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a	477					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		TACGTGTCCTCCTCATCTAGC	0.408																		2	4	---	---								-	52707832	C	-	52707832	7	5	23	1	0	1	0	1	0	0	0	0	10325	864	30	0	99	0	NEK3	13	52707832	Frame_Shift_Del	DEL	C	TCGA-C4-A0F0-01A-12D-A10S-08	3760203	52707832	62462046	68	6673										
LMO7	4008	broad.mit.edu	37	chr13	76427232	76427232	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cttttttgtgtttcagaggcGaatctttagataacctggac	9	7	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr13:76427232G>T	uc001vjv.2	+	25	4430	c.3670G>T	c.(3670-3672)GAA>TAA	p.E1224*	LMO7_uc010thv.1_Nonsense_Mutation_p.E1175*|LMO7_uc010thw.1_Nonsense_Mutation_p.E1101*	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1509						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTTCAGAGGCGAATCTTTAGA	0.378													1	0	1.55811e-20	0.008361	1.82909e-20	27	81										T	76427232	G	T	76427232	4	4	23	1	0	0	0	0	0	1	0	0	8855	1059	37	3	4639	3	LMO7	13	76427232	Nonsense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	23719400	76427232	38742646	69	6674										
BMP4	652	broad.mit.edu	37	chr14	54418914	54418914	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	acttggcataataaaacgacCatcagcattcggttaccagg	8	10	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr14:54418914C>A	uc001xal.3	-	2	214	c.27G>T	c.(25-27)ATG>ATT	p.M9I	BMP4_uc010aoh.2_Missense_Mutation_p.M9I|BMP4_uc001xao.3_Missense_Mutation_p.M9I|BMP4_uc001xan.3_Missense_Mutation_p.M9I	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	9					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						ATAAAACGACCATCAGCATTC	0.493													1	0	2.45108e-15	0.00874	2.75746e-15	42	65										A	54418914	C	A	54418914	3	1	23	1	0	0	0	0	1	0	0	0	1462	594	21	4	1207	4	BMP4	14	54418914	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08		54418914	52930626	70	6675										
ANGEL1	23357	broad.mit.edu	37	chr14	77275517	77275517	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	atgctccaggccaacaccgcTgggtcctcttcccactgctc	8	18	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr14:77275517T>C	uc001xsv.2	-	2	647	c.534A>G	c.(532-534)CCA>CCG	p.P178P	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	178										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CCAACACCGCTGGGTCCTCTT	0.652													0	0	0	0.00499	0	15	37										C	77275517	T	C	77275517	2	2	23	1	0	0	0	0	0	0	0	1	608	1567	55	5		5	ANGEL1	14	77275517	Silent	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	22856603	77275517	30074023	71	6676										
ATP10A	57194	broad.mit.edu	37	chr15	25925012	25925012	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cttcgggaggcgtccctgagCaaaggtctctttgggagcac	14	11	1	1	rs141308074		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr15:25925012C>A	uc010ayu.2	-	21	4082	c.3976G>T	c.(3976-3978)GCT>TCT	p.A1326S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1326	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CGTCCCTGAGCAAAGGTCTCT	0.597													1	0	1.02067e-35	0.01441	1.21938e-35	50	50										A	25925012	C	A	25925012	3	1	23	1	0	0	0	0	1	0	0	0	1116	710	25	4	527	4	ATP10A	15	25925012	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08		25925012	76606380	72	6677										
MAP2K1	5604	broad.mit.edu	37	chr15	66777338	66777338	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tctcctgcagccagaaagacTccaggggactcattactctg	9	13	3	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr15:66777338T>A	uc010bhq.2	+	7	1179	c.704T>A	c.(703-705)CTC>CAC	p.L235H	MAP2K1_uc010ujp.1_Missense_Mutation_p.L213H	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	235	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CCAGAAAGACTCCAGGGGACT	0.517									Cardiofaciocutaneous_syndrome				0	0	0	0.01441	0	86	143										A	66777338	T	A	66777338	3	1	23	1	0	0	0	0	1	0	0	0	9236	1551	54	5	730	5	MAP2K1	15	66777338	Missense_Mutation	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	40852326	66777338	35754054	73	6678										
FBXO22	26263	broad.mit.edu	37	chr15	76225291	76225291	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agttttttcctagtgttcccTtattcggcttctttggaaat	7	8	1	0	rs150074021		TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr15:76225291T>G	uc002bbk.2	+	7	1165	c.1060T>G	c.(1060-1062)TTA>GTA	p.L354V	FBXO22_uc002bbl.2_Missense_Mutation_p.L250V|FBXO22OS_uc002bbm.1_RNA	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	354					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						TAGTGTTCCCTTATTCGGCTT	0.408													0	0	0	0.01441	0	49	87										G	76225291	T	G	76225291	3	3	23	1	0	0	0	0	1	0	0	0	5734	1606	56	5	1123	5	FBXO22	15	76225291	Missense_Mutation	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	9447953	76225291	26306101	74	6679										
ST20	400410	broad.mit.edu	37	chr15	80191455	80191455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tttaggctcaagcttctttaCaaagccattttcctatgaga	6	9	2	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr15:80191455C>T	uc002bez.3	-	3	738	c.58G>A	c.(58-60)GTA>ATA	p.V20I	ST20_uc002bfa.3_Missense_Mutation_p.V20I|MTHFS_uc002bex.3_5'Flank	NM_001100879	NP_001094349	Q9HBF5	ST20_HUMAN	cervical cancer suppressor-1	20											0						AGCTTCTTTACAAAGCCATTT	0.318													0	0	0	0.008871	0	18	44										T	80191455	C	T	80191455	3	4	23	1	0	0	0	0	1	0	0	0	15212	478	17	2	185	2	ST20	15	80191455	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	3966164	80191455	22339937	75	6680										
CLUAP1	23059	broad.mit.edu	37	chr16	3556338	3556338	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cctctcttgatagatatgagCcccagactgacatcccgcct	7	15	1	5			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:3556338C>G	uc002cvk.1	+	3	247	c.142C>G	c.(142-144)CCC>GCC	p.P48A	CLUAP1_uc002cvj.1_Missense_Mutation_p.P48A|CLUAP1_uc002cvl.1_Missense_Mutation_p.P48A	NM_015041	NP_055856	Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1 isoform 1	48						nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TAGATATGAGCCCCAGACTGA	0.483													0	0	0	0.01441	0	80	48										G	3556338	C	G	3556338	3	3	23	1	0	0	0	0	1	0	0	0	3569	739	26	4	152	4	CLUAP1	16	3556338	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08		3556338	86798415	76	6681										
CREBBP	1387	broad.mit.edu	37	chr16	3788647	3788647	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gtggccggaagaaatgaataCtatccagataagaaatgtac	10	6	0	4			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:3788647C>T	uc002cvv.2	-	26	4511	c.4307G>A	c.(4306-4308)AGT>AAT	p.S1436N	CREBBP_uc002cvw.2_Missense_Mutation_p.S1398N	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1436	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GAAATGAATACTATCCAGATA	0.423			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.010818	0	33	11										T	3788647	C	T	3788647	3	4	23	1	0	0	0	0	1	0	0	0	3861	565	20	2	3045	2	CREBBP	16	3788647	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	232309	3788647	86566106	77	6682										
CP110	9738	broad.mit.edu	37	chr16	19547561	19547561	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aatgaagcttttccaaagacCtcttcagcaaccccacaaga	5	13	2	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:19547561C>G	uc002dgl.3	+	4	817	c.570C>G	c.(568-570)ACC>ACG	p.T190T	CP110_uc002dgk.3_Silent_p.T190T			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	190	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						TTCCAAAGACCTCTTCAGCAA	0.393													0	0	0	0.01441	0	126	66										G	19547561	C	G	19547561	2	3	23	1	0	0	0	0	0	0	0	1	3788	668	24	4		4	CP110	16	19547561	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	15758914	19547561	70807192	78	6683										
GP2	2813	broad.mit.edu	37	chr16	20337750	20337750	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	catcctttccataaggtgagGcatgcaggtcactttgctgt	10	10	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:20337750G>C	uc002dgv.2	-	2	87	c.4C>G	c.(4-6)CCT>GCT	p.P2A	GP2_uc002dgw.2_Missense_Mutation_p.P2A|GP2_uc002dgx.2_Missense_Mutation_p.P2A|GP2_uc002dgy.2_Missense_Mutation_p.P2A	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	2						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						ATAAGGTGAGGCATGCAGGTC	0.498													0	0	0	0.01441	0	68	30										C	20337750	G	C	20337750	3	2	23	1	0	0	0	0	1	0	0	0	6582	1203	42	4	1653	4	GP2	16	20337750	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	790189	20337750	70017003	79	6684										
FTO	79068	broad.mit.edu	37	chr16	53967950	53967950	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gggctccccgtggaacaaagGaatgaaatcttgactgccat	11	10	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:53967950G>A	uc002ehr.2	+	8	1515	c.1293G>A	c.(1291-1293)AGG>AGA	p.R431R	FTO_uc010vha.1_Silent_p.R135R|FTO_uc010cbz.2_Silent_p.R32R|FTO_uc002ehs.2_RNA	NM_001080432	NP_001073901	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	431					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGGAACAAAGGAATGAAATCT	0.428													0	0	0	0.009096	0	4	64										A	53967950	G	A	53967950	2	1	23	1	0	0	0	0	0	0	0	1	6086	1165	41	1		1	FTO	16	53967950	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	33630200	53967950	36386803	80	6685										
CDH1	999	broad.mit.edu	37	chr16	68842337	68842337	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttccttttaggcctccgtttCtggaatccaagcagaattgc	8	11	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:68842337C>T	uc002ewg.1	+	4	522	c.398C>T	c.(397-399)TCT>TTT	p.S133F	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.S133F	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	133					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GCCTCCGTTTCTGGAATCCAA	0.478			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.01441	0	51	78										T	68842337	C	T	68842337	3	4	23	1	0	0	0	0	1	0	0	0	3095	913	32	1	412	1	CDH1	16	68842337	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	14874387	68842337	21512416	81	6686										
HYDIN	54768	broad.mit.edu	37	chr16	70917863	70917863	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agcaaagtgtaaagaatgccGgcagggtggactgcagggtc	16	7	0	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr16:70917863G>A	uc002ezr.2	-	59	10064	c.9936C>T	c.(9934-9936)GCC>GCT	p.A3312A		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3313										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AAAGAATGCCGGCAGGGTGGA	0.488													0	0	0	0.016723	0	13	59										A	70917863	G	A	70917863	2	1	23	1	0	0	0	0	0	0	0	1	7467	1103	39	2		2	HYDIN	16	70917863	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	2075526	70917863	19436890	82	6687										
SMTNL2	342527	broad.mit.edu	37	chr17	4510756	4510756	+	Frame_Shift_Del	DEL	T	T	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tcacctacgtccagtcgctgTacaaccacctgcgtcgcttc							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr17:4510756delT	uc002fyf.1	+	8	1427	c.1360delT	c.(1360-1362)TACfs	p.Y454fs	SMTNL2_uc002fye.2_Frame_Shift_Del_p.Y310fs|uc002fyg.1_5'Flank	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	454	CH.										0				READ - Rectum adenocarcinoma(115;0.0325)		CCAGTCGCTGTACAACCACCT	0.612																		117	91	---	---								-	4510756	T	-	4510756	7	5	23	1	0	1	0	1	0	0	0	0	14816	1638	57	0	1390	0	SMTNL2	17	4510756	Frame_Shift_Del	DEL	T	TCGA-C4-A0F0-01A-12D-A10S-08		4510756	76684454	83	6688										
KRT32	3882	broad.mit.edu	37	chr17	39623211	39623211	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttggatcctgctctccagctCcgcattctcctgctccagct	7	17	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr17:39623211C>T	uc002hwr.2	-	1	428	c.367G>A	c.(367-369)GAG>AAG	p.E123K		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	123	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				CTCTCCAGCTCCGCATTCTCC	0.572													0	0	0	0.013114	0	49	148										T	39623211	C	T	39623211	3	4	23	1	0	0	0	0	1	0	0	0	8468	864	30	1	1007	1	KRT32	17	39623211	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	35112455	39623211	41571999	84	6689										
TLK2	11011	broad.mit.edu	37	chr17	60673977	60673977	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gggaataccggattcataaaGagctggatcatcccagaata	10	8	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr17:60673977G>C	uc010ddp.2	+	18	1826	c.1558G>C	c.(1558-1560)GAG>CAG	p.E520Q	TLK2_uc002izx.3_Missense_Mutation_p.E346Q|TLK2_uc002izz.3_Missense_Mutation_p.E498Q|TLK2_uc002jaa.3_Missense_Mutation_p.E466Q|TLK2_uc010wpd.1_Missense_Mutation_p.E466Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	520	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						GATTCATAAAGAGCTGGATCA	0.373													0	0	0	0.009718	0	40	118										C	60673977	G	C	60673977	3	2	23	1	0	0	0	0	1	0	0	0	15941	943	33	1	1554	1	TLK2	17	60673977	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	21050766	60673977	20521233	85	6690										
ARHGAP28	79822	broad.mit.edu	37	chr18	6876136	6876136	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tcattgctttctagttttttGagaaagttgaggaatcaggt	10	4	3	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr18:6876136G>C	uc010wzi.1	+	9	926	c.688G>C	c.(688-690)GAG>CAG	p.E230Q	ARHGAP28_uc002knc.2_Missense_Mutation_p.E355Q|ARHGAP28_uc002knd.2_Missense_Mutation_p.E248Q|ARHGAP28_uc002kne.2_Missense_Mutation_p.E248Q|ARHGAP28_uc002knf.2_Missense_Mutation_p.E239Q			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	230					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				CTAGTTTTTTGAGAAAGTTGA	0.318													0	0	0	0.006214	0	9	96										C	6876136	G	C	6876136	3	2	23	1	0	0	0	0	1	0	0	0	877	1291	45	1	772	1	ARHGAP28	18	6876136	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		6876136	71201112	86	6691										
DSC3	1825	broad.mit.edu	37	chr18	28576944	28576944	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gccctccatttttcattcctGatcccatagtaccacaaaaa	3	14	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr18:28576944G>C	uc002kwj.3	-	15	2461	c.2306C>G	c.(2305-2307)TCA>TGA	p.S769*	DSC3_uc002kwi.3_Nonsense_Mutation_p.S769*	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	769	Cytoplasmic (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TTTCATTCCTGATCCCATAGT	0.433													0	0	0	0.012319	0	22	64										C	28576944	G	C	28576944	4	2	23	1	0	0	0	0	0	1	0	0	4767	1294	45	1	423	1	DSC3	18	28576944	Nonsense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	21700808	28576944	49500304	87	6692										
DCC	1630	broad.mit.edu	37	chr18	50450132	50450132	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	agaccatccaatgtagtagcCattgaaggaaaagatgctgt	10	7	0	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr18:50450132C>A	uc002lfe.1	+	4	1340	c.753C>A	c.(751-753)GCC>GCA	p.A251A	DCC_uc010xdr.1_Silent_p.A99A	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	251	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ATGTAGTAGCCATTGAAGGAA	0.418													1	0	1.08052e-11	0.019004	1.19566e-11	35	53										A	50450132	C	A	50450132	2	1	23	1	0	0	0	0	0	0	0	1	4282	581	21	4		4	DCC	18	50450132	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	21873188	50450132	27627116	88	6693										
DCC	1630	broad.mit.edu	37	chr18	51013172	51013172	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ctttttcttttgcagctgtcGtgagcgccatcccggtgcca	10	13	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr18:51013172G>A	uc002lfe.1	+	26	4329	c.3742G>A	c.(3742-3744)GTG>ATG	p.V1248M	DCC_uc010dpf.1_Missense_Mutation_p.V883M	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1248	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGCAGCTGTCGTGAGCGCCAT	0.488													0	0	0	0.01441	0	67	94										A	51013172	G	A	51013172	3	1	23	1	0	0	0	0	1	0	0	0	4282	1145	40	2	3844	2	DCC	18	51013172	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	563040	51013172	27064076	89	6694										
C19orf28	126321	broad.mit.edu	37	chr19	3550991	3550991	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	caggctcccacctgagtgccGtgagctccaccttctcatgg	10	16	1	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:3550991G>A	uc002lxz.2	-	2	670	c.500C>T	c.(499-501)ACG>ATG	p.T167M	C19orf28_uc002lxw.2_Missense_Mutation_p.T167M|C19orf28_uc002lxx.2_Missense_Mutation_p.T167M|C19orf28_uc002lxy.2_Missense_Mutation_p.T158M	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	167					transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGAGTGCCGTGAGCTCCAC	0.557													0	0	0	0.014323	0	23	15										A	3550991	G	A	3550991	3	1	23	1	0	0	0	0	1	0	0	0	1917	1145	40	2	1185	2	C19orf28	19	3550991	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		3550991	55577992	90	6695										
CCL25	6370	broad.mit.edu	37	chr19	8122718	8122718	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tgtaaagaagttgagttctgGaaactccaagttatcatcgt	9	6	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:8122718G>C	uc002mjd.2	+	4	359	c.359G>C	c.(358-360)GGA>GCA	p.G120A	CCL25_uc002mjc.3_Missense_Mutation_p.G119A|CCL25_uc010dvy.1_Missense_Mutation_p.W75C	NM_005624	NP_005615	O15444	CCL25_HUMAN	small inducible cytokine A25 precursor	120					chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|hormone activity				0						ttgagttctggaaactccaag	0													0	0	0	0.009535	0	17	68										C	8122718	G	C	8122718	3	2	23	1	0	0	0	0	1	0	0	0	2897	1174	41	1	373	1	CCL25	19	8122718	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	4571727	8122718	51006265	91	6696										
ZNF714	148206	broad.mit.edu	37	chr19	21300901	21300901	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aacataattcatactggagaGaaatcttacaaatgtgaaga	7	5	2	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:21300901G>A	uc002npo.3	+	6	1794	c.1434G>A	c.(1432-1434)GAG>GAA	p.E478E	ZNF714_uc002npl.2_Silent_p.E323E|ZNF714_uc010ecp.1_Silent_p.E429E|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATACTGGAGAGAAATCTTACA	0.308													0	0	0	0.020292	0	14	42										A	21300901	G	A	21300901	2	1	23	1	0	0	0	0	0	0	0	1	18115	933	33	1		1	ZNF714	19	21300901	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	13178183	21300901	37828082	92	6697										
NFKBID	84807	broad.mit.edu	37	chr19	36387690	36387690	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gagcacctcagccgcagcatAtgccgcccagcgcagccccc	10	20	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:36387690A>T	uc002oci.1	-	6	770	c.196T>A	c.(196-198)TAT>AAT	p.Y66N	NFKBID_uc002och.1_5'Flank|NFKBID_uc002ocj.1_Missense_Mutation_p.Y81N	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	66	ANK 1.				inflammatory response	nucleus					0						GCCGCAGCATATGCCGCCCAG	0.473													0	0	0	0.012319	0	20	25										T	36387690	A	T	36387690	3	4	23	1	0	0	0	0	1	0	0	0	10379	449	16	5	773	5	NFKBID	19	36387690	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	15086789	36387690	22741293	93	6698										
FAM98C	147965	broad.mit.edu	37	chr19	38893808	38893808	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	actttcatggaggcggtgaaGgcggaagcgtgggagggggc	21	6	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:38893808G>A	uc002oin.1	+	1	34	c.15G>A	c.(13-15)AAG>AAA	p.K5K	FAM98C_uc002oio.1_Silent_p.K5K|FAM98C_uc010xtz.1_Silent_p.K5K	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	5										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGGCGGTGAAGGCGGAAGCGT	0.726													0	0	0	0.021553	0	4	22										A	38893808	G	A	38893808	2	1	23	1	0	0	0	0	0	0	0	1	5658	991	35	2		2	FAM98C	19	38893808	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	2506118	38893808	20235175	94	6699										
ZNF230	7773	broad.mit.edu	37	chr19	44514476	44514476	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gactgcccttgccagcaaatCtgggaacaaactgcaagtga	10	11	1	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:44514476C>G	uc002oyb.1	+	5	536	c.285C>G	c.(283-285)ATC>ATG	p.I95M		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	95	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GCCAGCAAATCTGGGAACAAA	0.468													0	0	0	0.010729	0	10	62										G	44514476	C	G	44514476	3	3	23	1	0	0	0	0	1	0	0	0	17781	903	32	1	299	1	ZNF230	19	44514476	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	5620668	44514476	14614507	95	6700										
ZNF211	10520	broad.mit.edu	37	chr19	58152819	58152819	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ccctgaatgtgggaaatcgtTtagtcagatatacagcctca	9	9	2	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr19:58152819T>C	uc002qpq.2	+	3	1145	c.965T>C	c.(964-966)TTT>TCT	p.F322S	ZNF211_uc010yhb.1_Missense_Mutation_p.F326S|ZNF211_uc002qpp.2_Missense_Mutation_p.F335S|ZNF211_uc002qpr.2_Missense_Mutation_p.F386S|ZNF211_uc002qps.2_Missense_Mutation_p.F387S|ZNF211_uc002qpt.2_Missense_Mutation_p.F334S|ZNF211_uc010yhc.1_Missense_Mutation_p.F334S|ZNF211_uc010yhd.1_Missense_Mutation_p.F261S|ZNF211_uc010yhe.1_Missense_Mutation_p.F313S	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	322	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGGAAATCGTTTAGTCAGATA	0.418													0	0	0	0.01441	0	49	75										C	58152819	T	C	58152819	3	2	23	1	0	0	0	0	1	0	0	0	17764	1841	64	5	1018	5	ZNF211	19	58152819	Missense_Mutation	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	13638343	58152819	976164	96	6701										
ProSAPiP1	9762	broad.mit.edu	37	chr20	3147630	3147630	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ctgccctggctgcccccaccCcctgtgcgggtacccacgct	10	21	0	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr20:3147630C>T	uc002wia.1	-	1	1578	c.180G>A	c.(178-180)GGG>GGA	p.G60G	ProSAPiP1_uc002wib.1_Silent_p.G60G	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	60	Poly-Gly.					cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						TGCCCCCACCCCCTGTGCGGG	0.716													0	0	0	0.010729	0	11	19										T	3147630	C	T	3147630	2	4	23	1	0	0	0	0	0	0	0	1	12870	610	22	2		2	ProSAPiP1	20	3147630	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08		3147630	59877890	97	6702										
CD93	22918	broad.mit.edu	37	chr20	23066316	23066316	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	gaagccctcaatgttacttcCgggggagcctgggctcccac	12	14	1	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr20:23066316C>T	uc002wsv.2	-	1	662	c.514G>A	c.(514-516)GGA>AGA	p.G172R		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	172	Extracellular (Potential).|C-type lectin.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					ATGTTACTTCCGGGGGAGCCT	0.652													0	0	0	0.016723	0	12	111										T	23066316	C	T	23066316	3	4	23	1	0	0	0	0	1	0	0	0	3047	661	23	2	1452	2	CD93	20	23066316	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	19918686	23066316	39959204	98	6703										
EMILIN3	90187	broad.mit.edu	37	chr20	39992445	39992445	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	cgggacagcaacgccaggcgAggtctgtcactgtcttgtag	14	11	3	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr20:39992445A>T	uc002xjy.1	-	3	571	c.347T>A	c.(346-348)CTC>CAC	p.L116H		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	116	EMI.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				ACGCCAGGCGAGGTCTGTCAC	0.617													0	0	0	0.01441	0	61	136										T	39992445	A	T	39992445	3	4	23	1	0	0	0	0	1	0	0	0	5095	304	11	5	1961	5	EMILIN3	20	39992445	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08	16926129	39992445	23033075	99	6704										
MMP9	4318	broad.mit.edu	37	chr20	44640354	44640354	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	caccaccgccaactacgaccGggacaagctcttcggcttct	8	17	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr20:44640354G>A	uc002xqz.2	+	6	984	c.965G>A	c.(964-966)CGG>CAG	p.R322Q		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	322	Fibronectin type-II 2.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	AACTACGACCGGGACAAGCTC	0.627											OREG0025989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	5	28										A	44640354	G	A	44640354	3	1	23	1	0	0	0	0	1	0	0	0	9669	1116	39	2	987	2	MMP9	20	44640354	Missense_Mutation	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	4647909	44640354	18385166	100	6705										
SON	6651	broad.mit.edu	37	chr21	34926719	34926719	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tttctgccaatattgaggatAttaatgaagcagatttagtg	9	4	1	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr21:34926719A>G	uc002yse.1	+	3	5231	c.5182A>G	c.(5182-5184)ATT>GTT	p.I1728V	SON_uc002ysb.1_Missense_Mutation_p.I1728V|SON_uc002ysc.2_Missense_Mutation_p.I1728V|SON_uc002ysd.2_Missense_Mutation_p.I719V|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.I719V	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1728					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						TATTGAGGATATTAATGAAGC	0.433													0	0	0	0.01441	0	78	150										G	34926719	A	G	34926719	3	3	23	1	0	0	0	0	1	0	0	0	14926	449	16	5	5192	5	SON	21	34926719	Missense_Mutation	SNP	A	TCGA-C4-A0F0-01A-12D-A10S-08		34926719	13203176	101	6706										
PCNT	5116	broad.mit.edu	37	chr21	47783573	47783573	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	acttgaactgagagaaaaggCtgaatccgagaaacagacca	10	8	0	6			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr21:47783573C>G	uc002zji.3	+	14	2440	c.2333C>G	c.(2332-2334)GCT>GGT	p.A778G	PCNT_uc002zjj.2_Missense_Mutation_p.A660G	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	778	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGAGAAAAGGCTGAATCCGAG	0.463													0	0	0	0.024245	0	15	149										G	47783573	C	G	47783573	3	3	23	1	0	0	0	0	1	0	0	0	11590	797	28	4	2387	4	PCNT	21	47783573	Missense_Mutation	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	12856854	47783573	346322	102	6707										
POTEH	23784	broad.mit.edu	37	chr22	16279260	16279260	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aaaaatttcaccacttgctgTttttgctcatgtacaccaag	5	10	2	0			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr22:16279260T>C	uc010gqp.2	-	4	1015	c.963A>G	c.(961-963)AAA>AAG	p.K321K	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.K40K|POTEH_uc002zlj.1_Silent_p.K156K	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	321	ANK 5.									skin(1)	1						CCACTTGCTGTTTTTGCTCAT	0.323													0	0	0	0.015359	0	32	446										C	16279260	T	C	16279260	2	2	23	1	0	0	0	0	0	0	0	1	12267	1722	60	5		5	POTEH	22	16279260	Silent	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08		16279260	35025306	103	6708										
SLC5A4	6527	broad.mit.edu	37	chr22	32647856	32647856	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ttactggcaaagagagaggcGcccatctggaatgcaagaga	13	8	1	3			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr22:32647856G>A	uc003ami.2	-	3	215	c.213C>T	c.(211-213)GGC>GGT	p.G71G		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	71	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						AGAGAGAGGCGCCCATCTGGA	0.438													0	0	0	0.01441	0	44	35										A	32647856	G	A	32647856	2	1	23	1	0	0	0	0	0	0	0	1	14667	1074	38	2		2	SLC5A4	22	32647856	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08	16368596	32647856	18656710	104	6709										
CSNK1E	1454	broad.mit.edu	37	chr22	38696882	38696883	+	Frame_Shift_Del	DEL	GC	GC	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	caggttgcccttcttccccaGccccatgaggaagttgtcgg							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chr22:38696882_38696883delGC	uc003avj.2	-	5	672_673	c.411_412delGC	c.(409-414)GGGCTGfs	p.G137fs	CSNK1E_uc003avk.2_Frame_Shift_Del_p.G137fs|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Frame_Shift_Del_p.G137fs|CSNK1E_uc003avo.2_Frame_Shift_Del_p.G137fs|CSNK1E_uc003avp.1_Frame_Shift_Del_p.G137fs|CSNK1E_uc003avq.1_Frame_Shift_Del_p.G137fs	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	137_138	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					TTCTTCCCCAGCCCCATGAGGA	0.569																		72	68	---	---								-	38696883	GC	-	38696882	7	5	23	1	0	1	0	1	0	0	0	0	3953	962	34	0	862	0	CSNK1E	22	38696882	Frame_Shift_Del	DEL	GC	TCGA-C4-A0F0-01A-12D-A10S-08	6049026	38696882	12607684	105	6710										
TMEM47	83604	broad.mit.edu	37	chrX	34657461	34657461	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	aggaatgcaatgagaatgatGgcagcgccgcccaggagtaa	14	8	0	2			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chrX:34657461G>T	uc004ddh.2	-	2	529	c.270C>A	c.(268-270)GCC>GCA	p.A90A	TMEM47_uc010ngs.2_RNA	NM_031442	NP_113630	Q9BQJ4	TMM47_HUMAN	transmembrane protein 47	90	Helical; (Potential).					integral to membrane				lung(1)	1						TGAGAATGATGGCAGCGCCGC	0.448													1	0	3.09899e-07	0.004482	3.3469e-07	8	7										T	34657461	G	T	34657461	2	4	23	1	0	0	0	0	0	0	0	1	16168	1335	47	4		4	TMEM47	23	34657461	Silent	SNP	G	TCGA-C4-A0F0-01A-12D-A10S-08		34657461	120613099	106	6711										
BCOR	54880	broad.mit.edu	37	chrX	39933138	39933138	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	caaccatttcctggaggagaTagtgtttctttcggaatctc	9	9	2	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chrX:39933138T>C	uc004den.3	-	4	1753	c.1461A>G	c.(1459-1461)CTA>CTG	p.L487L	BCOR_uc004dep.3_Silent_p.L487L|BCOR_uc004deo.3_Silent_p.L487L|BCOR_uc004dem.3_Silent_p.L487L|BCOR_uc004deq.3_Silent_p.L487L	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	487					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CTGGAGGAGATAGTGTTTCTT	0.512													0	0	0	0.009718	0	44	18										C	39933138	T	C	39933138	2	2	23	1	0	0	0	0	0	0	0	1	1386	1393	49	5		5	BCOR	23	39933138	Silent	SNP	T	TCGA-C4-A0F0-01A-12D-A10S-08	5275677	39933138	115337422	107	6712										
CACNA1F	778	broad.mit.edu	37	chrX	49089732	49089749	+	Splice_Site	DEL	GAAGGATTCTCTCACCTT	GAAGGATTCTCTCACCTT	-													0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	tccaagggtctgcagggatgGaaggattctctcacctttcc							TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chrX:49089732_49089749delGAAGGATTCTCTCACCTT	uc004dnb.2	-	1	87	c.25_splice	c.e1+1	p.D9_splice	CACNA1F_uc010nip.2_Splice_Site_p.D9_splice|CCDC22_uc011mna.1_5'Flank|CCDC22_uc004dnc.1_5'Flank|CCDC22_uc004dnd.1_5'Flank	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	TGCAGGGATGGAAGGATTCTCTCACCTTTCCCGCCTTC	0.578																		11	26	---	---								-	49089749	GAAGGATTCTCTCACCTT	-	49089732	8	5	23	1	0	1	0	1	0	0	1	0	2543	1189	41	0		0	CACNA1F	23	49089732	Splice_Site	DEL	GAAGGATTCTCTCACCTT	TCGA-C4-A0F0-01A-12D-A10S-08	9156594	49089732	106180828	108	6713										
ABCD1	215	broad.mit.edu	37	chrX	152994806	152994806	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.12962962962963	14	0.0453015394525457	1.64263547386011	3.02860915492958	1.12692433671798	1	1	5	ctcatgaagtatgtgtggagCgcctcgggcctgctcatggt	14	10	2	1			TCGA-C4-A0F0-01A-12D-A10S-08	TCGA-C4-A0F0-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	612fd956-9a41-4201-9d74-6ab50f6ae987	02addf8a-9108-4a60-bba3-c45d654a30f7	g.chrX:152994806C>T	uc004fif.2	+	2	1419	c.1020C>T	c.(1018-1020)AGC>AGT	p.S340S		NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	340	ABC transmembrane type-1.|Helical; (Potential).				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATGTGTGGAGCGCCTCGGGCC	0.597													0	0	0	0.028581	0	14	110										T	152994806	C	T	152994806	2	4	23	1	0	0	0	0	0	0	0	1	60	767	27	2		2	ABCD1	23	152994806	Silent	SNP	C	TCGA-C4-A0F0-01A-12D-A10S-08	103905074	152994806	2275754	109	6714										
PTCHD2	57540	broad.mit.edu	37	chr1	11561631	11561631	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gacacttccgcggctcaaaaGcccacagccaatcggagcgg	11	15	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:11561631G>T	uc001ash.3	+	2	720	c.582G>T	c.(580-582)AAG>AAT	p.K194N	PTCHD2_uc001asi.1_Missense_Mutation_p.K194N	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	194	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CGGCTCAAAAGCCCACAGCCA	0.697													1	0	0.00448238	0.047766	0.00450083	8	12										T	11561631	G	T	11561631	3	4	24	1	0	0	0	0	1	0	0	0	12733	962	34	4	584	4	PTCHD2	1	11561631	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		11561631	237688990	1	6715										
ATP13A2	23400	broad.mit.edu	37	chr1	17330838	17330838	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gactcctacctgacctggtaGaaggcttgctgggtctcgat	12	11	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:17330838G>A	uc001baa.2	-	6	736	c.546C>T	c.(544-546)TTC>TTT	p.F182F	ATP13A2_uc001bab.2_Silent_p.F177F|ATP13A2_uc001bac.2_Silent_p.F177F	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	182	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		TGACCTGGTAGAAGGCTTGCT	0.433													0	0	0	0.047766	0	7	31										A	17330838	G	A	17330838	2	1	24	1	0	0	0	0	0	0	0	1	1124	933	33	1		1	ATP13A2	1	17330838	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	5769207	17330838	231919783	2	6716										
C1orf38	9473	broad.mit.edu	37	chr1	28212380	28212380	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	actcggactcttttgcagatGatgatgaacatgattatgaa	9	6	1	6			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:28212380G>A	uc001bpc.3	+	6	1907	c.1879G>A	c.(1879-1881)GAT>AAT	p.D627N	C1orf38_uc001boz.2_3'UTR|C1orf38_uc001bpa.2_3'UTR|C1orf38_uc010ofn.1_Missense_Mutation_p.D431N|C1orf38_uc010ofo.1_Missense_Mutation_p.D498N	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	627	Asp/Glu-rich.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTGCAGATGATGATGAACA	0.299													0	0	0	0.069288	0	21	62										A	28212380	G	A	28212380	3	1	24	1	0	0	0	0	1	0	0	0	2039	1290	45	1	1901	1	C1orf38	1	28212380	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	10881542	28212380	221038241	3	6717										
TINAGL1	64129	broad.mit.edu	37	chr1	32043028	32043028	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gacttctgggacttctgcctCggcgtgccacccccttttcc	9	17	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:32043028C>T	uc001bta.2	+	2	405	c.279C>T	c.(277-279)CTC>CTT	p.L93L	TINAGL1_uc001bsz.2_Intron|TINAGL1_uc010ogi.1_Silent_p.L93L|TINAGL1_uc010ogj.1_Silent_p.L93L|TINAGL1_uc010ogk.1_Silent_p.L93L	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	93	SMB.				endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		ACTTCTGCCTCGGCGTGCCAC	0.607													0	0	0	0.048971	0	60	162										T	32043028	C	T	32043028	2	4	24	1	0	0	0	0	0	0	0	1	15919	871	31	1		1	TINAGL1	1	32043028	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	3830648	32043028	217207593	4	6718										
SPOCD1	90853	broad.mit.edu	37	chr1	32264127	32264127	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtgccttgtgtcaggtcccaGagggctgcctcaatgccagc	13	13	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:32264127G>T	uc001bts.1	-	8	2002	c.1944C>A	c.(1942-1944)CTC>CTA	p.L648L	SPOCD1_uc001btt.2_Translation_Start_Site|SPOCD1_uc001btu.2_Silent_p.L648L|SPOCD1_uc001btv.2_Silent_p.L141L|SPOCD1_uc001btw.1_Translation_Start_Site	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	648	TFIIS central.				transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCAGGTCCCAGAGGGCTGCCT	0.642													1	0	6.53275e-17	0.020292	7.02199e-17	14	58										T	32264127	G	T	32264127	2	4	24	1	0	0	0	0	0	0	0	1	15077	929	33	3		3	SPOCD1	1	32264127	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	221099	32264127	216986494	5	6719										
VCAM1	7412	broad.mit.edu	37	chr1	101194673	101194673	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgtgtcccagagaaaccattTactgttgagatctcccctgg	9	11	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:101194673T>C	uc001dti.2	+	5	1059	c.939T>C	c.(937-939)TTT>TTC	p.F313F	VCAM1_uc001dtj.2_Intron|VCAM1_uc010ouj.1_Silent_p.F251F	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	313	Ig-like C2-type 4.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGAAACCATTTACTGTTGAGA	0.413													0	0	0	0.020292	0	13	31										C	101194673	T	C	101194673	2	2	24	1	0	0	0	0	0	0	0	1	17134	1751	61	5		5	VCAM1	1	101194673	Silent	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	68930546	101194673	148055948	6	6720										
CELSR2	1952	broad.mit.edu	37	chr1	109806818	109806818	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccatgcacagctggcactggGagccagcggggggcccggcc	17	15	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:109806818G>A	uc001dxa.3	+	10	5181	c.5120G>A	c.(5119-5121)GGA>GAA	p.G1707E		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1707	Extracellular (Potential).|Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTGGCACTGGGAGCCAGCGGG	0.667											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.054565	0	28	94										A	109806818	G	A	109806818	3	1	24	1	0	0	0	0	1	0	0	0	3222	1174	41	1	5158	1	CELSR2	1	109806818	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	8612145	109806818	139443803	7	6721										
CELSR2	1952	broad.mit.edu	37	chr1	109806952	109806952	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gcggaatacctgggccagccGgcggtgtggcccgtggcttt	17	12	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:109806952G>A	uc001dxa.3	+	10	5315	c.5254G>A	c.(5254-5256)GGC>AGC	p.G1752S		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1752	Extracellular (Potential).|Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TGGGCCAGCCGGCGGTGTGGC	0.667											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.036044	0	36	111										A	109806952	G	A	109806952	3	1	24	1	0	0	0	0	1	0	0	0	3222	1116	39	2	5292	2	CELSR2	1	109806952	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	134	109806952	139443669	8	6722										
POLR3C	10623	broad.mit.edu	37	chr1	145608196	145608196	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggtggcccagggtctgaattCtcagtggtaggtaccgaagg	16	8	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:145608196C>T	uc001eoh.2	-	4	662	c.501G>A	c.(499-501)GAG>GAA	p.E167E	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Silent_p.E180E|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Silent_p.E167E	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	167					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			GGTCTGAATTCTCAGTGGTAG	0.478													0	0	0	0.041601	0	30	187										T	145608196	C	T	145608196	2	4	24	1	0	0	0	0	0	0	0	1	12230	912	32	1		1	POLR3C	1	145608196	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	35801244	145608196	103642425	9	6723										
HRNR	388697	broad.mit.edu	37	chr1	152193724	152193724	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gcactccaacttgaatgactAaaagaggattcttgccgttt	8	9	1	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:152193724A>T	uc001ezt.1	-	3	457	c.381T>A	c.(379-381)TTT>TTA	p.F127L		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	127	1.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGAATGACTAAAAGAGGATT	0.438													0	0	0	0.048971	0	55	297										T	152193724	A	T	152193724	3	4	24	1	0	0	0	0	1	0	0	0	7359	359	13	5	8175	5	HRNR	1	152193724	Missense_Mutation	SNP	A	TCGA-C4-A0F1-01A-11D-A10S-08	6585528	152193724	97056897	10	6724										
DCAF6	55827	broad.mit.edu	37	chr1	168034939	168034939	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atttgatgcttctggaagctGataatcatgtggtaaactgc	10	6	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:168034939G>C	uc001gew.2	+	16	2520	c.2278G>C	c.(2278-2280)GAT>CAT	p.D760H	DCAF6_uc001gev.2_Missense_Mutation_p.D780H|DCAF6_uc001gex.2_Missense_Mutation_p.D851H|DCAF6_uc010plk.1_Missense_Mutation_p.D820H|DCAF6_uc001gey.2_Missense_Mutation_p.D633H|DCAF6_uc001gez.2_Missense_Mutation_p.D65H	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	760	WD 7.				positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCTGGAAGCTGATAATCATGT	0.443													0	0	0	0.048971	0	48	36										C	168034939	G	C	168034939	3	2	24	1	0	0	0	0	1	0	0	0	4274	1290	45	1	2404	1	DCAF6	1	168034939	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	15841215	168034939	81215682	11	6725										
CACNA1S	779	broad.mit.edu	37	chr1	201056980	201056980	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aggacacccagcaccaggttGaggatgaagaaggatcccag	13	10	0	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:201056980G>A	uc001gvv.2	-	7	1205	c.978C>T	c.(976-978)CTC>CTT	p.L326L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	326	I.|Helical; Name=S6 of repeat I; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCACCAGGTTGAGGATGAAGA	0.393													0	0	0	0.080935	0	11	81										A	201056980	G	A	201056980	2	1	24	1	0	0	0	0	0	0	0	1	2547	1277	45	1		1	CACNA1S	1	201056980	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	33022041	201056980	48193641	12	6726										
C4BPA	722	broad.mit.edu	37	chr1	207314560	207314560	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gataaaggctacattctggtCggacaggcgaaactctcctg	11	10	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:207314560C>T	uc001hfo.2	+	10	1577	c.1383C>T	c.(1381-1383)GTC>GTT	p.V461V		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	461	Sushi 7.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						ACATTCTGGTCGGACAGGCGA	0.413													0	0	0	0.027356	0	27	112										T	207314560	C	T	207314560	2	4	24	1	0	0	0	0	0	0	0	1	2249	871	31	1		1	C4BPA	1	207314560	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	6257580	207314560	41936061	13	6727										
MIA3	375056	broad.mit.edu	37	chr1	222826648	222826648	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtcaaaataaaggtggaaatGattcagatgaattagcaaat	9	3	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:222826648G>C	uc001hnl.2	+	15	4297	c.4288G>C	c.(4288-4290)GAT>CAT	p.D1430H	MIA3_uc009xea.1_Missense_Mutation_p.D1207H|MIA3_uc001hnm.2_Missense_Mutation_p.D308H	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1430	Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		AGGTGGAAATGATTCAGATGA	0.418													0	0	0	0.0333	0	16	56										C	222826648	G	C	222826648	3	2	24	1	0	0	0	0	1	0	0	0	9565	1290	45	1	4346	1	MIA3	1	222826648	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	15512088	222826648	26423973	14	6728										
NID1	4811	broad.mit.edu	37	chr1	236208952	236208952	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tggcataggagctggaatcaGaggaggctagaacagcctgg	16	7	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr1:236208952G>C	uc001hxo.2	-	3	659	c.557C>G	c.(556-558)TCT>TGT	p.S186C	NID1_uc009xgd.2_Missense_Mutation_p.S186C	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	186	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCTGGAATCAGAGGAGGCTAG	0.413													0	0	0	0.028581	0	17	65										C	236208952	G	C	236208952	3	2	24	1	0	0	0	0	1	0	0	0	10414	942	33	1	3258	1	NID1	1	236208952	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	13382304	236208952	13041669	15	6729										
KCNS3	3790	broad.mit.edu	37	chr2	18112633	18112633	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttgattcttgctgcagcaatCgctaccaggaacgcaaggag	11	10	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:18112633C>T	uc002rcv.2	+	3	809	c.358C>T	c.(358-360)CGC>TGC	p.R120C	KCNS3_uc002rcw.2_Missense_Mutation_p.R120C	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	120	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTGCAGCAATCGCTACCAGGA	0.507													0	0	0	0.092188	0	40	133										T	18112633	C	T	18112633	3	4	24	1	0	0	0	0	1	0	0	0	8090	884	31	1	360	1	KCNS3	2	18112633	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		18112633	225086740	16	6730										
APOB	338	broad.mit.edu	37	chr2	21239390	21239390	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tctgtaagacgttttgccctCagtagattcatcattaactc	6	10	4	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:21239390C>T	uc002red.2	-	21	3381	c.3253G>A	c.(3253-3255)GAG>AAG	p.E1085K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1085					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTTTTGCCCTCAGTAGATTCA	0.453													0	0	0	0.069288	0	24	59										T	21239390	C	T	21239390	3	4	24	1	0	0	0	0	1	0	0	0	785	835	29	1	10474	1	APOB	2	21239390	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	3126757	21239390	221959983	17	6731										
APOB	338	broad.mit.edu	37	chr2	21250702	21250702	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	caaactcttcacacttacctCgatgaggtcagctgaagcaa	7	12	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:21250702C>T	uc002red.2	-	14	2193	c.2065G>A	c.(2065-2067)GAG>AAG	p.E689K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	689					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACACTTACCTCGATGAGGTCA	0.433													0	0	0	0.049695	0	18	54										T	21250702	C	T	21250702	3	4	24	1	0	0	0	0	1	0	0	0	785	893	31	1	11690	1	APOB	2	21250702	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	11312	21250702	221948671	18	6732										
TP53I3	9540	broad.mit.edu	37	chr2	24305998	24305998	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	caaaatgttgctggctcctgGaggtgggtcatactggcctt	13	9	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:24305998G>A	uc002rey.1	-	3	223	c.163C>T	c.(163-165)CCA>TCA	p.P55S	LOC375190_uc002rew.2_Intron|TP53I3_uc002rex.1_Missense_Mutation_p.P55S|TP53I3_uc002rez.1_Missense_Mutation_p.P55S|TP53I3_uc010ykk.1_Silent_p.L4L	NM_147184	NP_671713	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	55					induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGGCTCCTGGAGGTGGGTCA	0.562													0	0	0	0.048971	0	60	145										A	24305998	G	A	24305998	3	1	24	1	0	0	0	0	1	0	0	0	16384	1174	41	1	851	1	TP53I3	2	24305998	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	3055296	24305998	218893375	19	6733										
AFTPH	54812	broad.mit.edu	37	chr2	64779737	64779737	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tggattctgttaaaacttctGatgatgaagttggttctccc	9	7	3	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:64779737G>C	uc002sdc.2	+	1	1161	c.1129G>C	c.(1129-1131)GAT>CAT	p.D377H	AFTPH_uc002scz.2_Missense_Mutation_p.D377H|AFTPH_uc002sda.2_Missense_Mutation_p.D377H|AFTPH_uc002sdb.2_Missense_Mutation_p.D377H	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	377					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						TAAAACTTCTGATGATGAAGT	0.348													0	0	0	0.037714	0	30	78										C	64779737	G	C	64779737	3	2	24	1	0	0	0	0	1	0	0	0	364	1290	45	1	1131	1	AFTPH	2	64779737	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	40473739	64779737	178419636	20	6734										
VWA3B	200403	broad.mit.edu	37	chr2	98737802	98737802	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agtggcaggaaaatgctactCctgtgaccgaacagtccata	10	10	0	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:98737802C>T	uc002syo.2	+	5	847	c.583C>T	c.(583-585)CCT>TCT	p.P195S	VWA3B_uc010yvh.1_Missense_Mutation_p.P45S|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Missense_Mutation_p.P195S|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	195										ovary(3)|large_intestine(2)|skin(1)	6						AAATGCTACTCCTGTGACCGA	0.537													0	0	0	0.038395	0	15	44										T	98737802	C	T	98737802	3	4	24	1	0	0	0	0	1	0	0	0	17238	855	30	1	597	1	VWA3B	2	98737802	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	33958065	98737802	144461571	21	6735										
MERTK	10461	broad.mit.edu	37	chr2	112766049	112766049	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acccaaatgtcattcgacttCtaggtacttccgagaaatgc	7	11	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:112766049C>G	uc002thk.1	+	14	2079	c.1957C>G	c.(1957-1959)CTA>GTA	p.L653V	MERTK_uc002thl.1_Missense_Mutation_p.L477V	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	653	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						CATTCGACTTCTAGGTACTTC	0.488													0	0	0	0.0918	0	25	52										G	112766049	C	G	112766049	3	3	24	1	0	0	0	0	1	0	0	0	9479	912	32	1	2011	1	MERTK	2	112766049	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	14028247	112766049	130433324	22	6736										
GALNT5	11227	broad.mit.edu	37	chr2	158165235	158165235	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	caacatcagtctttcatccaGaactggtaagcaaaagattg	7	9	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:158165235G>C	uc002tzg.2	+	9	2932	c.2677G>C	c.(2677-2679)GAA>CAA	p.E893Q	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	893	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						CTTTCATCCAGAACTGGTAAG	0.408													0	0	0	0.069288	0	22	52										C	158165235	G	C	158165235	3	2	24	1	0	0	0	0	1	0	0	0	6216	943	33	1	2711	1	GALNT5	2	158165235	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	45399186	158165235	85034138	23	6737										
UPP2	151531	broad.mit.edu	37	chr2	158980394	158980394	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tttgcagctatgtgtggactCtgtggtctaaaaggtaagct	12	6	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:158980394C>G	uc002tzp.2	+	6	992	c.798C>G	c.(796-798)CTC>CTG	p.L266L	UPP2_uc002tzo.2_Silent_p.L323L	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	266					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						TGTGTGGACTCTGTGGTCTAA	0.388													0	0	0	0.09836	0	36	102										G	158980394	C	G	158980394	2	3	24	1	0	0	0	0	0	0	0	1	17010	900	32	1		1	UPP2	2	158980394	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	815159	158980394	84218979	24	6738										
INPP1	3628	broad.mit.edu	37	chr2	191227381	191227381	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cttggaaaaaaatatttttgGagaagaatccaatgagttta	8	3	0	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:191227381G>A	uc002ury.3	+	4	933	c.233G>A	c.(232-234)GGA>GAA	p.G78E	INPP1_uc010fsb.2_Missense_Mutation_p.G78E|INPP1_uc002urx.3_Missense_Mutation_p.G78E	NM_001128928	NP_001122400	P49441	INPP_HUMAN	inositol polyphosphate-1-phosphatase	78					signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)	AATATTTTTGGAGAAGAATCC	0.303													0	0	0	0.030593	0	22	73										A	191227381	G	A	191227381	3	1	24	1	0	0	0	0	1	0	0	0	7751	1174	41	1	239	1	INPP1	2	191227381	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	32246987	191227381	51971992	25	6739										
MOGAT1	116255	broad.mit.edu	37	chr2	223553091	223553091	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tccattggaatcactgtgatGctgatcatacacaactattt	6	9	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:223553091G>T	uc010fws.1	+	2	171	c.123G>T	c.(121-123)ATG>ATT	p.M41I	MOGAT1_uc010fwt.1_Missense_Mutation_p.M1I	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	41	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		TCACTGTGATGCTGATCATAC	0.473													1	0	5.9392e-07	0.021553	6.03819e-07	5	12										T	223553091	G	T	223553091	3	4	24	1	0	0	0	0	1	0	0	0	9694	1319	46	4	129	4	MOGAT1	2	223553091	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	32325710	223553091	19646282	26	6740										
SLC16A14	151473	broad.mit.edu	37	chr2	230902218	230902218	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acatatgtagaaggaaaaatCatatttttgcgtgatgtcat	8	4	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:230902218C>T	uc002vqd.1	-	5	1774	c.1411G>A	c.(1411-1413)GAT>AAT	p.D471N	FBXO36_uc010fxi.1_Intron	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	471	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AAGGAAAAATCATATTTTTGC	0.333													0	0	0	0.050027	0	32	42										T	230902218	C	T	230902218	3	4	24	1	0	0	0	0	1	0	0	0	14407	826	29	1	125	1	SLC16A14	2	230902218	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	7349127	230902218	12297155	27	6741										
UGT1A3	54659	broad.mit.edu	37	chr2	234638460	234638460	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tttgccatgctttttctgctCcttatgcaagccttgcctct	6	13	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:234638460C>A	uc002vuy.2	+	1	688	c.688C>A	c.(688-690)CCT>ACT	p.P230T	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.P230T	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	230					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TTTTTCTGCTCCTTATGCAAG	0.468													1	0	2.05912e-35	0.048971	2.26318e-35	86	263										A	234638460	C	A	234638460	3	1	24	1	0	0	0	0	1	0	0	0	16943	855	30	3	690	3	UGT1A3	2	234638460	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	3736242	234638460	8560913	28	6742										
SH3BP4	23677	broad.mit.edu	37	chr2	235962412	235962412	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtgaactccctggacgttctGagagcagccgccttcagccc	11	15	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr2:235962412G>A	uc002vvp.2	+	6	3237	c.2844G>A	c.(2842-2844)CTG>CTA	p.L948L	SH3BP4_uc010fym.2_Silent_p.L930L|SH3BP4_uc002vvq.2_Silent_p.L948L	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	948					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TGGACGTTCTGAGAGCAGCCG	0.597													0	0	0	0.048971	0	75	176										A	235962412	G	A	235962412	2	1	24	1	0	0	0	0	0	0	0	1	14246	1277	45	1		1	SH3BP4	2	235962412	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	1323952	235962412	7236961	29	6743										
LRRN1	57633	broad.mit.edu	37	chr3	3887565	3887565	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggcaccaggtgaaggaagttTtaatccaggattcgagtgaa	13	6	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:3887565T>A	uc003bpt.3	+	2	2001	c.1240T>A	c.(1240-1242)TTA>ATA	p.L414I	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	414	LRRCT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GAAGGAAGTTTTAATCCAGGA	0.488													0	0	0	0.039052	0	39	93										A	3887565	T	A	3887565	3	1	24	1	0	0	0	0	1	0	0	0	9034	1838	64	5	1242	5	LRRN1	3	3887565	Missense_Mutation	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08		3887565	194134865	30	6744										
ATG7	10533	broad.mit.edu	37	chr3	11354786	11354786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttttttttctaggatctaaaGaagtaccacttctactattg	5	7	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:11354786G>C	uc003bwc.2	+	6	537	c.420G>C	c.(418-420)AAG>AAC	p.K140N	ATG7_uc003bwd.2_Missense_Mutation_p.K140N|ATG7_uc011aum.1_Intron	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	140					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						AGGATCTAAAGAAGTACCACT	0.373													0	0	0	0.028581	0	14	63										C	11354786	G	C	11354786	3	2	24	1	0	0	0	0	1	0	0	0	1101	933	33	1	438	1	ATG7	3	11354786	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	7467221	11354786	186667644	31	6745										
KCNH8	131096	broad.mit.edu	37	chr3	19492801	19492801	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tttctgtgctccgggggagtAtctgctgcgtcaaggggatg	16	8	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:19492801A>G	uc003cbk.1	+	10	1925	c.1730A>G	c.(1729-1731)TAT>TGT	p.Y577C	KCNH8_uc011awe.1_3'UTR|KCNH8_uc010hex.1_Missense_Mutation_p.Y38C|KCNH8_uc011awf.1_3'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	577	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CCGGGGGAGTATCTGCTGCGT	0.512													0	0	0	0.034045	0	30	68										G	19492801	A	G	19492801	3	3	24	1	0	0	0	0	1	0	0	0	8038	449	16	5	1768	5	KCNH8	3	19492801	Missense_Mutation	SNP	A	TCGA-C4-A0F1-01A-11D-A10S-08	8138015	19492801	178529629	32	6746										
SGOL1	151648	broad.mit.edu	37	chr3	20218129	20218129	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttctccttgtcctggaagttCagtttcttcaagaggaattt	8	8	4	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:20218129C>T	uc003cbs.2	-	5	626	c.439G>A	c.(439-441)GAA>AAA	p.E147K	SGOL1_uc003cbr.2_Missense_Mutation_p.E147K|SGOL1_uc010hfa.2_Missense_Mutation_p.E147K|SGOL1_uc003cbt.2_Missense_Mutation_p.E147K|SGOL1_uc003cbu.2_Missense_Mutation_p.E147K|SGOL1_uc003cbv.2_Missense_Mutation_p.E147K|SGOL1_uc003cbw.2_Missense_Mutation_p.E147K|SGOL1_uc003cbx.2_Missense_Mutation_p.E147K|SGOL1_uc003cby.2_Missense_Mutation_p.E147K|SGOL1_uc003cbz.2_Missense_Mutation_p.E147K|SGOL1_uc003cca.2_Missense_Mutation_p.E147K|SGOL1_uc003ccb.2_Missense_Mutation_p.E147K|SGOL1_uc003ccc.2_Missense_Mutation_p.E147K	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	147	Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						CCTGGAAGTTCAGTTTCTTCA	0.254													0	0	0	0.09319	0	11	46										T	20218129	C	T	20218129	3	4	24	1	0	0	0	0	1	0	0	0	14216	835	29	1	1286	1	SGOL1	3	20218129	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	725328	20218129	177804301	33	6747										
GLB1	2720	broad.mit.edu	37	chr3	33038825	33038825	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccaaggttaaagccattaatCcagacctggccctggagaga	10	11	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:33038825C>A	uc003cfi.1	-	16	1863	c.1746G>T	c.(1744-1746)TGG>TGT	p.W582C	GLB1_uc003cfh.1_Missense_Mutation_p.W552C|GLB1_uc003cfj.1_Missense_Mutation_p.W451C|GLB1_uc011axk.1_Missense_Mutation_p.W630C	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	582					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				AGCCATTAATCCAGACCTGGC	0.597													1	0	1.56452e-12	0.043863	1.65257e-12	18	40										A	33038825	C	A	33038825	3	1	24	1	0	0	0	0	1	0	0	0	6427	856	30	3	291	3	GLB1	3	33038825	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	12820696	33038825	164983605	34	6748										
MLH1	4292	broad.mit.edu	37	chr3	37035075	37035075	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gggttattcggcggctggacGagacagtggtgaaccgcatc	16	9	0	2	rs63750081		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:37035075G>A	uc003cgl.2	+	1	97	c.37G>A	c.(37-39)GAG>AAG	p.E13K	MLH1_uc011aye.1_5'Flank|EPM2AIP1_uc003cgk.2_5'Flank|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Missense_Mutation_p.E13K|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	13					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						GCGGCTGGACGAGACAGTGGT	0.567		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.030593	0	25	75										A	37035075	G	A	37035075	3	1	24	1	0	0	0	0	1	0	0	0	9617	1059	37	1	39	1	MLH1	3	37035075	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	3996250	37035075	160987355	35	6749										
VIPR1	7433	broad.mit.edu	37	chr3	42576579	42576579	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgaagatggtctttgagctcGtcgtggggtctttccaggta	14	7	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:42576579G>A	uc003clf.2	+	11	1247	c.1123G>A	c.(1123-1125)GTC>ATC	p.V375I	VIPR1_uc011azl.1_Missense_Mutation_p.V327I|VIPR1_uc011azm.1_Missense_Mutation_p.V165I|VIPR1_uc011azn.1_Missense_Mutation_p.V348I|VIPR1_uc003clg.2_Missense_Mutation_p.V20I	NM_004624	NP_004615	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	375	Helical; Name=7; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CTTTGAGCTCGTCGTGGGGTC	0.498													0	0	0	0.048971	0	64	167										A	42576579	G	A	42576579	3	1	24	1	0	0	0	0	1	0	0	0	17166	1145	40	2	1165	2	VIPR1	3	42576579	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	5541504	42576579	155445851	36	6750										
CELSR3	1951	broad.mit.edu	37	chr3	48698816	48698817	+	Missense_Mutation	DNP	TC	TC	AT													0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggctactgtcacggccaccaTcgtggtggccgagaggcgcg					rs111946927		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:48698816_48698817TC>AT	uc003cul.2	-	1	1532_1533	c.1251_1252GA>AT	c.(1249-1254)ACGATG>ACATTG	p.M418L	CELSR3_uc003cuf.1_Missense_Mutation_p.M488L	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	418	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACGGCCACCATCGTGGTGGCCG	0.658													0	0	0	0.004672	0	17	56										AT	48698817	TC	AT	48698816	3	1	24	1	0	0	0	0	1	0	0	0	3223	1435	50	5	8826	5	CELSR3	3	48698816	Missense_Mutation	DNP	TC	TCGA-C4-A0F1-01A-11D-A10S-08	6122237	48698816	149323614	37	6751										
C3orf71	646450	broad.mit.edu	37	chr3	48956327	48956327	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agcgcgggcttgaccggcgtCggcccgccgcctccgctgcc	15	19	0	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:48956327C>T	uc010hkk.1	-	1	492	c.256G>A	c.(256-258)GAC>AAC	p.D86N	ARIH2_uc003cvb.2_5'UTR|ARIH2_uc003cvc.2_5'UTR	NM_001123040	NP_001116512	Q8N7S6	CC071_HUMAN	hypothetical protein LOC646450	86						integral to membrane					0						TGACCGGCGTCGGCCCGCCGC	0.721													0	0	0	0.02938	0	5	9										T	48956327	C	T	48956327	3	4	24	1	0	0	0	0	1	0	0	0	2243	884	31	1	620	1	C3orf71	3	48956327	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	257511	48956327	149066103	38	6752										
LAMB2	3913	broad.mit.edu	37	chr3	49166159	49166159	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cacagaggccaccaggaactCcagggtctgaccttcctgta	10	14	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:49166159C>G	uc003cwe.2	-	14	2124	c.1825G>C	c.(1825-1827)GAG>CAG	p.E609Q	LAMB2_uc003cwf.1_Missense_Mutation_p.E609Q	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	609	Laminin IV type B.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACCAGGAACTCCAGGGTCTGA	0.607													0	0	0	0.048971	0	47	105										G	49166159	C	G	49166159	3	3	24	1	0	0	0	0	1	0	0	0	8611	864	30	1	3647	1	LAMB2	3	49166159	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	209832	49166159	148856271	39	6753										
SRPRB	58477	broad.mit.edu	37	chr3	133534474	133534474	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atagtgcagcattccagcgaGaggtgaaagatgtggctgag	15	6	0	4			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:133534474G>A	uc003epx.1	+	5	467	c.451G>A	c.(451-453)GAG>AAG	p.E151K		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	151						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						ATTCCAGCGAGAGGTGAAAGA	0.433													0	0	0	0.048971	0	216	164										A	133534474	G	A	133534474	3	1	24	1	0	0	0	0	1	0	0	0	15162	943	33	1	469	1	SRPRB	3	133534474	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	84368315	133534474	64487956	40	6754										
ATR	545	broad.mit.edu	37	chr3	142231262	142231262	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gatgcaatgtcttgggtattTatggtatgctgatcgtcatg	12	5	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:142231262T>G	uc003eux.3	-	27	4814	c.4692A>C	c.(4690-4692)ATA>ATC	p.I1564I		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1564					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CTTGGGTATTTATGGTATGCT	0.353								Other_conserved_DNA_damage_response_genes					0	0	0	0.048971	0	49	166										G	142231262	T	G	142231262	2	3	24	1	0	0	0	0	0	0	0	1	1204	1744	61	5		5	ATR	3	142231262	Silent	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	8696788	142231262	55791168	41	6755										
SUCNR1	56670	broad.mit.edu	37	chr3	151599155	151599155	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cactcaggtcgtcatcaactCcttttacattgtgacacggc	7	13	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:151599155C>T	uc003ezf.1	+	3	923	c.824C>T	c.(823-825)TCC>TTC	p.S275F		NM_033050	NP_149039	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	275	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	GTCATCAACTCCTTTTACATT	0.473													0	0	0	0.048971	0	154	131										T	151599155	C	T	151599155	3	4	24	1	0	0	0	0	1	0	0	0	15365	855	30	1	830	1	SUCNR1	3	151599155	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	9367893	151599155	46423275	42	6756										
DHX36	170506	broad.mit.edu	37	chr3	154018909	154018909	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tctgtgttctttttgttctgGaacatacctaaaataaaaac	5	7	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:154018909G>C	uc003ezy.3	-	10	1306	c.1225C>G	c.(1225-1227)CCA>GCA	p.P409A	DHX36_uc010hvq.2_Missense_Mutation_p.P409A|DHX36_uc003ezz.3_Missense_Mutation_p.P409A	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	409						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTTGTTCTGGAACATACCTA	0.294													0	0	0	0.064281	0	37	134										C	154018909	G	C	154018909	3	2	24	1	0	0	0	0	1	0	0	0	4509	1174	41	1	1865	1	DHX36	3	154018909	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	2419754	154018909	44003521	43	6757										
ACTL6A	86	broad.mit.edu	37	chr3	179291159	179291159	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	actaatcttatattctagttGaagactgggatagtttccaa	7	6	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:179291159G>A	uc003fjw.2	+	4	453	c.280G>A	c.(280-282)GAA>AAA	p.E94K	ACTL6A_uc003fjx.2_Missense_Mutation_p.E52K|ACTL6A_uc003fjy.2_Missense_Mutation_p.E52K	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	94					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			TATTCTAGTTGAAGACTGGGA	0.343													0	0	0	0.0918	0	27	120										A	179291159	G	A	179291159	3	1	24	1	0	0	0	0	1	0	0	0	198	1291	45	1	294	1	ACTL6A	3	179291159	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	25272250	179291159	18731271	44	6758										
USP13	8975	broad.mit.edu	37	chr3	179460036	179460036	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atgtttttcgttttttggtgGaagaacgcattcagtgctgt	11	5	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr3:179460036G>A	uc003fkh.2	+	12	1513	c.1432G>A	c.(1432-1434)GAA>AAA	p.E478K	USP13_uc003fkf.2_Missense_Mutation_p.E478K	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	478					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TTTTTTGGTGGAAGAACGCAT	0.488													0	0	0	0.049695	0	17	117										A	179460036	G	A	179460036	3	1	24	1	0	0	0	0	1	0	0	0	17041	1175	41	1	1478	1	USP13	3	179460036	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	168877	179460036	18562394	45	6759										
CRIPAK	285464	broad.mit.edu	37	chr4	1389009	1389009	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgctcacacgtgccgatgcgGagtgcccgcctgctcacacg	12	16	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:1389009G>T	uc003gdf.2	+	1	3670	c.710G>T	c.(709-711)GGA>GTA	p.G237V		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	237	6.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TGCCGATGCGGAGTGCCCGCC	0.677													1	0	5.04308e-16	0.086207	5.37341e-16	24	156										T	1389009	G	T	1389009	3	4	24	1	0	0	0	0	1	0	0	0	3877	1174	41	3	712	3	CRIPAK	4	1389009	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		1389009	189765267	46	6760										
FAM193A	8603	broad.mit.edu	37	chr4	2701583	2701583	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agagctgtaaaaaagaagaaGaaggagaggccaagtaaaga	13	3	0	6			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:2701583G>C	uc010icl.2	+	17	3162	c.2811G>C	c.(2809-2811)AAG>AAC	p.K937N	FAM193A_uc010ick.2_Missense_Mutation_p.K1137N|FAM193A_uc003gfd.2_Missense_Mutation_p.K937N|FAM193A_uc011bvm.1_Missense_Mutation_p.K959N|FAM193A_uc011bvn.1_Missense_Mutation_p.K937N|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.K791N	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	937	Poly-Lys.									ovary(3)	3						AAAAGAAGAAGAAGGAGAGGC	0.383													0	0	0	0.041601	0	28	74										C	2701583	G	C	2701583	3	2	24	1	0	0	0	0	1	0	0	0	5524	933	33	1	2869	1	FAM193A	4	2701583	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	1312574	2701583	188452693	47	6761										
BOD1L	259282	broad.mit.edu	37	chr4	13602850	13602850	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aatcaagaccccttcactttCttctcctaaccctgtacaag	3	15	4	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:13602850C>T	uc003gmz.1	-	10	5791	c.5674G>A	c.(5674-5676)GAA>AAA	p.E1892K	BOD1L_uc010idr.1_Missense_Mutation_p.E1229K	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1892							DNA binding			ovary(5)|breast(1)	6						CCTTCACTTTCTTCTCCTAAC	0.483													0	0	0	0.104719	0	41	105										T	13602850	C	T	13602850	3	4	24	1	0	0	0	0	1	0	0	0	1483	922	32	1	3549	1	BOD1L	4	13602850	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	10901267	13602850	177551426	48	6762										
CC2D2A	57545	broad.mit.edu	37	chr4	15569099	15569099	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cacaatgctgactaccccctCggccaggtgagagatgctgg	12	13	0	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:15569099C>T	uc010idv.2	+	26	3527	c.3282C>T	c.(3280-3282)CTC>CTT	p.L1094L	CC2D2A_uc003gnx.2_Silent_p.L1045L|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1094	C2.				cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						ACTACCCCCTCGGCCAGGTGA	0.493													0	0	0	0.020292	0	14	50										T	15569099	C	T	15569099	2	4	24	1	0	0	0	0	0	0	0	1	2728	871	31	1		1	CC2D2A	4	15569099	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	1966249	15569099	175585177	49	6763										
TLR10	81793	broad.mit.edu	37	chr4	38777082	38777082	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgtggctggggtcaagtctgCgggaacctttcttagagaca	14	8	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:38777082C>T	uc003gti.2	-	2	509	c.130G>A	c.(130-132)GCA>ACA	p.A44T	TLR10_uc003gtj.2_Missense_Mutation_p.A44T|TLR10_uc003gtk.2_Missense_Mutation_p.A44T	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	44	Extracellular (Potential).|LRR 1.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						GTCAAGTCTGCGGGAACCTTT	0.448													0	0	0	0.049695	0	19	42										T	38777082	C	T	38777082	3	4	24	1	0	0	0	0	1	0	0	0	15947	768	27	2	2309	2	TLR10	4	38777082	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	23207983	38777082	152377194	50	6764										
KDR	3791	broad.mit.edu	37	chr4	55961077	55961077	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccgtttcagatccacagggaTtgctccaacgtagtctttcc	8	13	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:55961077T>A	uc003has.2	-	21	3165	c.2863A>T	c.(2863-2865)ATC>TTC	p.I955F	KDR_uc003hat.1_Missense_Mutation_p.I955F	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	955	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TCCACAGGGATTGCTCCAACG	0.463			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.076483	0	24	61										A	55961077	T	A	55961077	3	1	24	1	0	0	0	0	1	0	0	0	8139	1493	52	5	1247	5	KDR	4	55961077	Missense_Mutation	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	17183995	55961077	135193199	51	6765										
KDR	3791	broad.mit.edu	37	chr4	55961105	55961105	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acgtagtctttcccttgacgGaatcgtgcccctttggtcta	9	12	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:55961105G>A	uc003has.2	-	21	3137	c.2835C>T	c.(2833-2835)TTC>TTT	p.F945F	KDR_uc003hat.1_Silent_p.F945F	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	945	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TCCCTTGACGGAATCGTGCCC	0.433			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.055883	0	20	48										A	55961105	G	A	55961105	2	1	24	1	0	0	0	0	0	0	0	1	8139	1165	41	1		1	KDR	4	55961105	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	28	55961105	135193171	52	6766										
GRID2	2895	broad.mit.edu	37	chr4	94693231	94693231	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttttcttcatctccaggatgAcaaggaaattgacctggagc	9	9	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:94693231A>G	uc011cdt.1	+	16	2864	c.2606A>G	c.(2605-2607)GAC>GGC	p.D869G	GRID2_uc011cdu.1_Missense_Mutation_p.D774G	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	869	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CTCCAGGATGACAAGGAAATT	0.383													0	0	0	0.049695	0	18	67										G	94693231	A	G	94693231	3	3	24	1	0	0	0	0	1	0	0	0	6772	275	10	5	2668	5	GRID2	4	94693231	Missense_Mutation	SNP	A	TCGA-C4-A0F1-01A-11D-A10S-08	38732126	94693231	96461045	53	6767										
EGF	1950	broad.mit.edu	37	chr4	110890162	110890162	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acagccctgaagtggatagaGagagctaatatggatggttc	13	6	0	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:110890162G>C	uc003hzy.3	+	11	2063	c.1611G>C	c.(1609-1611)GAG>GAC	p.E537D	EGF_uc011cfu.1_Missense_Mutation_p.E495D|EGF_uc011cfv.1_Missense_Mutation_p.E537D	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	537	LDL-receptor class B 6.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	AGTGGATAGAGAGAGCTAATA	0.403													0	0	0	0.059317	0	28	70										C	110890162	G	C	110890162	3	2	24	1	0	0	0	0	1	0	0	0	4962	933	33	1	1653	1	EGF	4	110890162	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	16196931	110890162	80264114	54	6768										
ANK2	287	broad.mit.edu	37	chr4	114158306	114158306	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acttctgcttcagaatgaccAcaatgctgacgtacaatcca	6	12	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:114158306A>G	uc003ibe.3	+	6	747	c.647A>G	c.(646-648)CAC>CGC	p.H216R	ANK2_uc003ibd.3_Missense_Mutation_p.H195R|ANK2_uc003ibf.3_Missense_Mutation_p.H216R|ANK2_uc003ibc.2_Missense_Mutation_p.H192R|ANK2_uc011cgb.1_Missense_Mutation_p.H231R	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	216	ANK 6.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGAATGACCACAATGCTGAC	0.483													0	0	0	0.048971	0	64	155										G	114158306	A	G	114158306	3	3	24	1	0	0	0	0	1	0	0	0	621	159	6	5	694	5	ANK2	4	114158306	Missense_Mutation	SNP	A	TCGA-C4-A0F1-01A-11D-A10S-08	3268144	114158306	76995970	55	6769										
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gccatcatattgaacacagcGgactgctgcaacatgaccca	8	13	1	2	rs149680468		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.020292	0	15	58										C	153247289	G	C	153247289	3	2	24	1	0	0	0	0	1	0	0	0	5769	1116	39	4	622	4	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	39088983	153247289	37906987	56	6770										
EGFLAM	133584	broad.mit.edu	37	chr5	38407204	38407204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctacacctgggggggctcgcGatgccagtgcaccctgggca	15	14	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:38407204G>A	uc003jlc.1	+	8	1427	c.1103G>A	c.(1102-1104)CGA>CAA	p.R368Q	EGFLAM_uc003jlb.1_Missense_Mutation_p.R368Q|EGFLAM_uc003jle.1_Missense_Mutation_p.R134Q|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	368	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GGGGGCTCGCGATGCCAGTGC	0.552													0	0	0	0.062417	0	22	52										A	38407204	G	A	38407204	3	1	24	1	0	0	0	0	1	0	0	0	4966	1058	37	1	1147	1	EGFLAM	5	38407204	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		38407204	142508056	57	6771										
IL6ST	3572	broad.mit.edu	37	chr5	55247891	55247891	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tttttgtccgaacagtaggtCctttggaaggtgctgtaaca	11	7	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:55247891C>G	uc003jqq.2	-	13	1820	c.1565G>C	c.(1564-1566)GGA>GCA	p.G522A	IL6ST_uc010iwb.2_Missense_Mutation_p.G461A|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.G233A|IL6ST_uc003jqr.2_3'UTR|IL6ST_uc010iwe.1_5'Flank	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	522	Extracellular (Potential).|Fibronectin type-III 5.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				AACAGTAGGTCCTTTGGAAGG	0.348			O		hepatocellular ca								0	0	0	0.027356	0	25	49										G	55247891	C	G	55247891	3	3	24	1	0	0	0	0	1	0	0	0	7703	855	30	1	1211	1	IL6ST	5	55247891	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	16840687	55247891	125667369	58	6772										
VCAN	1462	broad.mit.edu	37	chr5	82817190	82817190	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tatttctccagaaactatgaGaacaacaaaaatcacagagg	6	8	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:82817190G>A	uc003kii.3	+	7	3421	c.3065G>A	c.(3064-3066)AGA>AAA	p.R1022K	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.R1022K|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1022	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAAACTATGAGAACAACAAAA	0.433													0	0	0	0.038395	0	18	44										A	82817190	G	A	82817190	3	1	24	1	0	0	0	0	1	0	0	0	17135	942	33	1	3087	1	VCAN	5	82817190	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	27569299	82817190	98098070	59	6773										
GPR98	84059	broad.mit.edu	37	chr5	90106172	90106172	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acatgtacaaagactatttgGgttccacagcgatcttatta	7	8	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:90106172G>A	uc003kju.2	+	74	15191	c.15095G>A	c.(15094-15096)GGG>GAG	p.G5032E	GPR98_uc003kjt.2_Missense_Mutation_p.G2738E|GPR98_uc003kjw.2_Missense_Mutation_p.G693E	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5032	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGACTATTTGGGTTCCACAGC	0.403													0	0	0	0.038147	0	8	18										A	90106172	G	A	90106172	3	1	24	1	0	0	0	0	1	0	0	0	6721	1232	43	2	15389	2	GPR98	5	90106172	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	7288982	90106172	90809088	60	6774										
RFESD	317671	broad.mit.edu	37	chr5	94989768	94989768	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tctttatgttcaactagcatGaatcttgatggctctgcaca	7	9	4	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:94989768G>A	uc003klf.2	+	3	1395	c.3G>A	c.(1-3)ATG>ATA	p.M1I	RFESD_uc003klg.2_Missense_Mutation_p.M54I|RFESD_uc011cun.1_Missense_Mutation_p.M54I|SPATA9_uc010jbh.1_Intron|SPATA9_uc003klh.1_Intron|SPATA9_uc003kli.1_Intron	NM_173362	NP_775498	Q8TAC1	RFESD_HUMAN	Rieske (Fe-S) domain containing isoform 2	1							2 iron, 2 sulfur cluster binding|metal ion binding|oxidoreductase activity				0		all_cancers(142;0.000215)|all_epithelial(76;7.43e-07)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)|Colorectal(57;0.162)		all cancers(79;5.94e-17)		CAACTAGCATGAATCTTGATG	0.373													0	0	0	0.024245	0	14	47										A	94989768	G	A	94989768	3	1	24	1	0	0	0	0	1	0	0	0	13249	1290	45	1	172	1	RFESD	5	94989768	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	4883596	94989768	85925492	61	6775										
PPIP5K2	23262	broad.mit.edu	37	chr5	102526629	102526629	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	taaagcaagtggatgaatttCttgcttccattgcttctcca	7	9	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:102526629C>T	uc003kod.3	+	29	3958	c.3439C>T	c.(3439-3441)CTT>TTT	p.L1147F	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.L1126F|PPIP5K2_uc003kof.2_Missense_Mutation_p.L329F	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	1147					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						GGATGAATTTCTTGCTTCCAT	0.373													0	0	0	0.069456	0	33	72										T	102526629	C	T	102526629	3	4	24	1	0	0	0	0	1	0	0	0	12333	913	32	1	3482	1	PPIP5K2	5	102526629	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	7536861	102526629	78388631	62	6776										
GRIA1	2890	broad.mit.edu	37	chr5	153181955	153181955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gcctcagcaatgtggcaggcGtgttctacatcctgatcgga	12	11	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr5:153181955G>A	uc003lva.3	+	15	2790	c.2425G>A	c.(2425-2427)GTG>ATG	p.V809M	GRIA1_uc003luy.3_Missense_Mutation_p.V809M|GRIA1_uc003luz.3_Missense_Mutation_p.V714M|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.V729M|GRIA1_uc011dcx.1_Missense_Mutation_p.V740M|GRIA1_uc011dcy.1_Missense_Mutation_p.V819M|GRIA1_uc011dcz.1_Missense_Mutation_p.V819M	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	809	Helical; (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGTGGCAGGCGTGTTCTACAT	0.413													0	0	0	0.048971	0	45	101										A	153181955	G	A	153181955	3	1	24	1	0	0	0	0	1	0	0	0	6767	1145	40	2	2602	2	GRIA1	5	153181955	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	50655326	153181955	27733305	63	6777										
MSH5	4439	broad.mit.edu	37	chr6	31727896	31727896	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gatggaactctgtgcccgaaCctttgtgcccaactccacag	9	14	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:31727896C>A	uc003nwv.1	+	19	1794	c.1715C>A	c.(1714-1716)ACC>AAC	p.T572N	MSH5_uc003nwt.1_Missense_Mutation_p.T589N|MSH5_uc003nwu.1_Missense_Mutation_p.T572N|MSH5_uc003nww.1_Missense_Mutation_p.T572N|MSH5_uc003nwx.1_Missense_Mutation_p.T589N|MSH5_uc011dof.1_Missense_Mutation_p.T271N|MSH5_uc003nwy.1_Missense_Mutation_p.T246N|MSH5_uc003nwz.3_RNA|C6orf26_uc003nxa.3_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	572					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						TGTGCCCGAACCTTTGTGCCC	0.532								Direct_reversal_of_damage|MMR					1	0	9.34078e-37	0.048971	1.03129e-36	78	169										A	31727896	C	A	31727896	3	1	24	1	0	0	0	0	1	0	0	0	9873	507	18	4	1836	4	MSH5	6	31727896	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		31727896	139387171	64	6778										
SLC44A4	80736	broad.mit.edu	37	chr6	31838641	31838641	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	taggcactgaggttggtggtGaaacccagctgggagatgga	17	6	0	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:31838641G>A	uc010jti.2	-	10	951	c.885C>T	c.(883-885)TTC>TTT	p.F295F	SLC44A4_uc011dol.1_Silent_p.F219F|SLC44A4_uc011dom.1_Silent_p.F253F	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	295	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GGTTGGTGGTGAAACCCAGCT	0.662													0	0	0	0.036044	0	39	95										A	31838641	G	A	31838641	2	1	24	1	0	0	0	0	0	0	0	1	14638	1281	45	1		1	SLC44A4	6	31838641	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	110745	31838641	139276426	65	6779										
PHIP	55023	broad.mit.edu	37	chr6	79727268	79727268	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aaaataaacccgaataatatGatctgtgcttcccgtcgcca	6	11	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:79727268G>A	uc003pir.2	-	11	1253	c.1027C>T	c.(1027-1029)CAT>TAT	p.H343Y	PHIP_uc011dyp.1_Missense_Mutation_p.H343Y	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	343	WD 4.				insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		CGAATAATATGATCTGTGCTT	0.323													0	0	0	0.049695	0	18	39										A	79727268	G	A	79727268	3	1	24	1	0	0	0	0	1	0	0	0	11842	1290	45	1	4558	1	PHIP	6	79727268	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	47888627	79727268	91387799	66	6780										
C6orf165	154313	broad.mit.edu	37	chr6	88136336	88136336	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aaaatgaccataaaatcaaaGatagcggtcccaacatcaca	5	10	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:88136336G>C	uc003plv.2	+	8	1025	c.933G>C	c.(931-933)AAG>AAC	p.K311N	C6orf165_uc003plw.2_Missense_Mutation_p.K123N|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Missense_Mutation_p.K311N	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	311										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TAAAATCAAAGATAGCGGTCC	0.363													0	0	0	0.028581	0	15	37										C	88136336	G	C	88136336	3	2	24	1	0	0	0	0	1	0	0	0	2341	933	33	1	959	1	C6orf165	6	88136336	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	8409068	88136336	82978731	67	6781										
MDN1	23195	broad.mit.edu	37	chr6	90468570	90468570	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccagcaacaccagggatccaGaagatccttcaagcaaacca	7	14	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:90468570G>A	uc003pnn.1	-	18	2686	c.2570C>T	c.(2569-2571)TCT>TTT	p.S857F	MDN1_uc003pno.1_Missense_Mutation_p.S275F	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	857					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CAGGGATCCAGAAGATCCTTC	0.473													0	0	0	0.016723	0	13	40										A	90468570	G	A	90468570	3	1	24	1	0	0	0	0	1	0	0	0	9415	942	33	1	14560	1	MDN1	6	90468570	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	2332234	90468570	80646497	68	6782										
ASF1A	25842	broad.mit.edu	37	chr6	119226948	119226948	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtaaataatgaatatactgaGacagaattaagggaaaatcc	8	4	0	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:119226948G>A	uc011ebn.1	+	3	694	c.357G>A	c.(355-357)GAG>GAA	p.E119E		NM_014034	NP_054753	Q9Y294	ASF1A_HUMAN	ASF1 anti-silencing function 1 homolog A	119	Interaction with histone H3, CHAF1B, and HIRA.				chromatin modification|DNA repair|loss of chromatin silencing|nucleosome assembly|transcription, DNA-dependent	chromatin remodeling complex	chromatin binding|histone binding				0		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0633)|OV - Ovarian serous cystadenocarcinoma(136;0.188)		AATATACTGAGACAGAATTAA	0.323													0	0	0	0.041601	0	33	73										A	119226948	G	A	119226948	2	1	24	1	0	0	0	0	0	0	0	1	1037	933	33	1		1	ASF1A	6	119226948	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	28758378	119226948	51888119	69	6783										
SYNE1	23345	broad.mit.edu	37	chr6	152650896	152650896	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtaaggcttcctggatgtctCcatccagctctgagagctca	10	12	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:152650896C>G	uc010kiw.2	-	78	15526	c.14924G>C	c.(14923-14925)GGA>GCA	p.G4975A	SYNE1_uc003qot.3_Missense_Mutation_p.G4904A|SYNE1_uc003qou.3_Missense_Mutation_p.G4975A|SYNE1_uc010kiz.2_Missense_Mutation_p.G730A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4975	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGATGTCTCCATCCAGCTC	0.463										HNSCC(10;0.0054)			0	0	0	0.045515	0	48	134										G	152650896	C	G	152650896	3	3	24	1	0	0	0	0	1	0	0	0	15442	855	30	1	11818	1	SYNE1	6	152650896	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	33423948	152650896	18464171	70	6784										
TTLL2	83887	broad.mit.edu	37	chr6	167755005	167755005	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgcaagaccaagacctccccGtgtgtcctgtcagaccgtgg	11	14	1	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:167755005G>A	uc003qvs.1	+	3	1705	c.1617G>A	c.(1615-1617)CCG>CCA	p.P539P	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	539					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		AGACCTCCCCGTGTGTCCTGT	0.542													0	0	0	0.086207	0	40	77										A	167755005	G	A	167755005	2	1	24	1	0	0	0	0	0	0	0	1	16724	1132	40	2		2	TTLL2	6	167755005	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	15104109	167755005	3360062	71	6785										
SMOC2	64094	broad.mit.edu	37	chr6	169064768	169064768	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgctagcccccagaggtcatGctgaaagtacgtctaataga	10	10	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr6:169064768G>A	uc003qws.1	+	12	1320	c.1300G>A	c.(1300-1302)GCT>ACT	p.A434T	SMOC2_uc003qwr.1_Missense_Mutation_p.A445T|SMOC2_uc011egu.1_Missense_Mutation_p.A111T	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	434				A -> V (in Ref. 6; AAH47583).	signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CAGAGGTCATGCTGAAAGTAC	0.299													0	0	0	0.0333	0	16	43										A	169064768	G	A	169064768	3	1	24	1	0	0	0	0	1	0	0	0	14802	1319	46	2	1379	2	SMOC2	6	169064768	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	1309763	169064768	2050299	72	6786										
RNF216	54476	broad.mit.edu	37	chr7	5662766	5662766	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctccaccctctgcaccttctCcacaggcttctccagcgggg	8	19	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:5662766C>G	uc003soy.1	-	17	2516	c.2326G>C	c.(2326-2328)GAG>CAG	p.E776Q	RNF216_uc010ksz.1_Missense_Mutation_p.E398Q|RNF216_uc010kta.1_Missense_Mutation_p.E398Q|RNF216_uc011jwj.1_Missense_Mutation_p.E398Q|RNF216_uc003sox.1_Missense_Mutation_p.E833Q	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	776	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TGCACCTTCTCCACAGGCTTC	0.577													0	0	0	0.099896	0	23	66										G	5662766	C	G	5662766	3	3	24	1	0	0	0	0	1	0	0	0	13480	864	30	1	278	1	RNF216	7	5662766	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		5662766	153475897	73	6787			1	20		3	3	949	C		1.847408e-05
RNF216	54476	broad.mit.edu	37	chr7	5663694	5663694	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gaggggcacttgcctccattCtttcttttctgttcctcttc	7	13	4	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:5663694C>A	uc003soy.1	-	16	2464	c.2274G>T	c.(2272-2274)AAG>AAT	p.K758N	RNF216_uc010ksz.1_Missense_Mutation_p.K380N|RNF216_uc010kta.1_Missense_Mutation_p.K380N|RNF216_uc011jwj.1_Missense_Mutation_p.K380N|RNF216_uc003sox.1_Missense_Mutation_p.K815N	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	758	Potential.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TGCCTCCATTCTTTCTTTTCT	0.537													1	0	7.48243e-07	0.058154	7.57557e-07	10	21										A	5663694	C	A	5663694	3	1	24	1	0	0	0	0	1	0	0	0	13480	912	32	3	334	3	RNF216	7	5663694	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	928	5663694	153474969	74	6788			1	20		3	3	949	C		1.847408e-05
RNF216	54476	broad.mit.edu	37	chr7	5663714	5663714	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctttcttttctgttcctcttCagcctccttctggatttcct	4	14	5	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:5663714C>T	uc003soy.1	-	16	2444	c.2254G>A	c.(2254-2256)GAA>AAA	p.E752K	RNF216_uc010ksz.1_Missense_Mutation_p.E374K|RNF216_uc010kta.1_Missense_Mutation_p.E374K|RNF216_uc011jwj.1_Missense_Mutation_p.E374K|RNF216_uc003sox.1_Missense_Mutation_p.E809K	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	752	Potential.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TGTTCCTCTTCAGCCTCCTTC	0.547													0	0	0	0.047766	0	9	21										T	5663714	C	T	5663714	3	4	24	1	0	0	0	0	1	0	0	0	13480	835	29	1	354	1	RNF216	7	5663714	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	20	5663714	153474949	75	6789			1	20		3	3	949	C		1.847408e-05
HDAC9	9734	broad.mit.edu	37	chr7	18975511	18975511	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctagaaggaggacatgatctCacagccatctgtgatgcatc	10	10	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:18975511C>G	uc003suh.2	+	22	2915	c.2874C>G	c.(2872-2874)CTC>CTG	p.L958L	HDAC9_uc003sue.2_Silent_p.L958L|HDAC9_uc003sui.2_Silent_p.L961L|HDAC9_uc003suj.2_Silent_p.L917L|HDAC9_uc003suk.2_Silent_p.L206L	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	958	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GACATGATCTCACAGCCATCT	0.433													0	0	0	0.048971	0	68	143										G	18975511	C	G	18975511	2	3	24	1	0	0	0	0	0	0	0	1	7014	813	29	1		1	HDAC9	7	18975511	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	13311797	18975511	140163152	76	6790										
CDCA7L	55536	broad.mit.edu	37	chr7	21945945	21945945	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcggaagctgtaaaactcttCcgcaaatttagcggctgaga	10	9	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:21945945C>A	uc010kuk.2	-	6	1003	c.883G>T	c.(883-885)GAA>TAA	p.E295*	CDCA7L_uc003sve.3_Nonsense_Mutation_p.E261*|CDCA7L_uc010kul.2_Nonsense_Mutation_p.E249*|CDCA7L_uc003svf.3_Nonsense_Mutation_p.E294*	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	295					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						TAAAACTCTTCCGCAAATTTA	0.483													1	0	1.14385e-22	0.048971	1.23496e-22	54	145										A	21945945	C	A	21945945	4	1	24	1	0	0	0	0	0	1	0	0	3091	864	30	3	501	3	CDCA7L	7	21945945	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2970434	21945945	137192718	77	6791										
MAGI2	9863	broad.mit.edu	37	chr7	77885323	77885323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtccttaagtatatccactaCttctgtatggctcaggttct	7	10	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:77885323C>T	uc003ugx.2	-	10	2238	c.1984G>A	c.(1984-1986)GTA>ATA	p.V662I	MAGI2_uc003ugy.2_Missense_Mutation_p.V662I|MAGI2_uc010ldx.1_Missense_Mutation_p.V271I|MAGI2_uc010ldy.1_Missense_Mutation_p.V271I|MAGI2_uc011kgr.1_Missense_Mutation_p.V494I|MAGI2_uc011kgs.1_Missense_Mutation_p.V499I	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	662	PDZ 3.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ATATCCACTACTTCTGTATGG	0.438													0	0	0	0.080935	0	12	26										T	77885323	C	T	77885323	3	4	24	1	0	0	0	0	1	0	0	0	9191	565	20	2	2435	2	MAGI2	7	77885323	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	55939378	77885323	81253340	78	6792										
PCLO	27445	broad.mit.edu	37	chr7	82580534	82580534	+	Frame_Shift_Del	DEL	C	C	-													0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	taatgaagtcactgcatcagCcgtatgaataccagacaaat							TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:82580534delC	uc003uhx.2	-	6	9659	c.9370delG	c.(9370-9372)GCTfs	p.A3124fs	PCLO_uc003uhv.2_Frame_Shift_Del_p.A3124fs|PCLO_uc010lec.2_Frame_Shift_Del_p.A89fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3055					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTGCATCAGCCGTATGAATA	0.453																		12	21	---	---								-	82580534	C	-	82580534	7	5	24	1	0	1	0	1	0	0	0	0	11583	739	26	0	6155	0	PCLO	7	82580534	Frame_Shift_Del	DEL	C	TCGA-C4-A0F1-01A-11D-A10S-08	4695211	82580534	76558129	79	6793										
ZKSCAN1	7586	broad.mit.edu	37	chr7	99621928	99621928	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	accccgcctcttacagtcacGaggtaagaagcaaggtttca	9	12	3	1	rs148037051		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:99621928G>A	uc003usk.1	+	3	797	c.578G>A	c.(577-579)CGA>CAA	p.R193Q	ZKSCAN1_uc003usj.2_Missense_Mutation_p.R192Q|ZKSCAN1_uc003usl.1_Missense_Mutation_p.R157Q|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	193					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R193Q(1)		ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTACAGTCACGAGGTAAGAAG	0.488													0	0	0	0.028581	0	14	37										A	99621928	G	A	99621928	3	1	24	1	0	0	0	0	1	0	0	0	17683	1058	37	1	584	1	ZKSCAN1	7	99621928	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	17041394	99621928	59516735	80	6794										
AGFG2	3268	broad.mit.edu	37	chr7	100151098	100151098	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgatcctgcaccgtctctctCagttgctgcctccacctcga	7	17	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:100151098C>G	uc003uvf.2	+	4	696	c.560C>G	c.(559-561)TCA>TGA	p.S187*	AGFG2_uc003uvg.1_Intron|AGFG2_uc010lgy.2_Missense_Mutation_p.Q49E	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	187					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						CCGTCTCTCTCAGTTGCTGCC	0.542													0	0	0	0.064281	0	32	102										G	100151098	C	G	100151098	4	3	24	1	0	0	0	0	0	1	0	0	381	838	29	1	574	1	AGFG2	7	100151098	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	529170	100151098	58987565	81	6795										
GPR37	2861	broad.mit.edu	37	chr7	124404704	124404704	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggcctggttggaggtcccggGggtccggctgccgacgcctc	18	14	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:124404704G>T	uc003vli.2	-	1	978	c.327C>A	c.(325-327)CCC>CCA	p.P109P		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	109	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GAGGTCCCGGGGGTCCGGCTG	0.726													1	0	1.66031e-10	0.0918	1.72389e-10	24	48										T	124404704	G	T	124404704	2	4	24	1	0	0	0	0	0	0	0	1	6691	1219	43	4		4	GPR37	7	124404704	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	24253606	124404704	34733959	82	6796										
STRA8	346673	broad.mit.edu	37	chr7	134927560	134927560	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttctgaataaggcaaagagtCatattccagaactggagcaa	9	7	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:134927560C>A	uc011kpx.1	+	3	286	c.286C>A	c.(286-288)CAT>AAT	p.H96N		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	96	Potential.				DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						GGCAAAGAGTCATATTCCAGA	0.483													1	0	2.94398e-08	0.043863	3.03094e-08	20	71										A	134927560	C	A	134927560	3	1	24	1	0	0	0	0	1	0	0	0	15322	826	29	3	296	3	STRA8	7	134927560	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	10522856	134927560	24211103	83	6797										
TBXAS1	6916	broad.mit.edu	37	chr7	139655334	139655334	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tggactcctggcaggcccctGaggatccctttgtgaaacac	11	13	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:139655334G>A	uc011kqv.1	+	8	921	c.757G>A	c.(757-759)GAG>AAG	p.E253K	TBXAS1_uc003vvh.2_Missense_Mutation_p.E207K|TBXAS1_uc010lne.2_Missense_Mutation_p.E139K|TBXAS1_uc011kqu.1_Missense_Mutation_p.E158K|TBXAS1_uc003vvi.2_Missense_Mutation_p.E207K|TBXAS1_uc003vvj.2_Missense_Mutation_p.E207K|TBXAS1_uc011kqw.1_Missense_Mutation_p.E187K	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	206	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					GCAGGCCCCTGAGGATCCCTT	0.577													0	0	0	0.048971	0	50	124										A	139655334	G	A	139655334	3	1	24	1	0	0	0	0	1	0	0	0	15661	1291	45	1	787	1	TBXAS1	7	139655334	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	4727774	139655334	19483329	84	6798										
EPHA1	2041	broad.mit.edu	37	chr7	143096402	143096402	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agctctgtaatggccgctctCacaggtacagatggtggccc	12	12	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:143096402C>T	uc003wcz.2	-	5	1027	c.940G>A	c.(940-942)GAG>AAG	p.E314K		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	314	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TGGCCGCTCTCACAGGTACAG	0.657													0	0	0	0.039052	0	47	87										T	143096402	C	T	143096402	3	4	24	1	0	0	0	0	1	0	0	0	5165	835	29	1	2046	1	EPHA1	7	143096402	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	3441068	143096402	16042261	85	6799										
EPHA1	2041	broad.mit.edu	37	chr7	143096426	143096426	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggtacagatggtggccccctCagactcagcagtgctctgct	12	13	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:143096426C>T	uc003wcz.2	-	5	1003	c.916G>A	c.(916-918)GAG>AAG	p.E306K		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	306	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GTGGCCCCCTCAGACTCAGCA	0.657													0	0	0	0.045705	0	32	75										T	143096426	C	T	143096426	3	4	24	1	0	0	0	0	1	0	0	0	5165	835	29	1	2070	1	EPHA1	7	143096426	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	24	143096426	16042237	86	6800										
CUL1	8454	broad.mit.edu	37	chr7	148484186	148484186	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acagtgcaagtgacgatgccGaagccagcatgatctccaag	11	11	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:148484186G>A	uc010lpg.2	+	13	1979	c.1453G>A	c.(1453-1455)GAA>AAA	p.E485K	CUL1_uc003wey.2_Missense_Mutation_p.E485K|CUL1_uc003wez.2_Missense_Mutation_p.E375K|CUL1_uc003wfa.2_Missense_Mutation_p.E146K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	485					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGACGATGCCGAAGCCAGCAT	0.398													0	0	0	0.069288	0	21	54										A	148484186	G	A	148484186	3	1	24	1	0	0	0	0	1	0	0	0	4054	1059	37	1	1499	1	CUL1	7	148484186	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	5387760	148484186	10654477	87	6801										
SSPO	23145	broad.mit.edu	37	chr7	149512401	149512401	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtgccccctgggccagctctCccaggacgggctgtgcgtgc	15	16	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:149512401C>T	uc010lpk.2	+	76	10721	c.10721C>T	c.(10720-10722)TCC>TTC	p.S3574F		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3574					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCCAGCTCTCCCAGGACGGG	0.721													0	0	0	0.021553	0	6	17										T	149512401	C	T	149512401	3	4	24	1	0	0	0	0	1	0	0	0	15188	855	30	1	11013	1	SSPO	7	149512401	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	1028215	149512401	9626262	88	6802										
MLL3	58508	broad.mit.edu	37	chr7	151855998	151855998	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agagtacatagcttgtttctCctcttcgtcctttttccttt	5	11	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr7:151855998C>A	uc003wla.2	-	44	11839	c.11620G>T	c.(11620-11622)GAG>TAG	p.E3874*	MLL3_uc003wkz.2_Nonsense_Mutation_p.E2935*|MLL3_uc003wkx.2_5'Flank|MLL3_uc003wky.2_Nonsense_Mutation_p.E1383*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3874					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCTTGTTTCTCCTCTTCGTCC	0.448			N		medulloblastoma								1	0	2.43152e-32	0.048971	2.66049e-32	102	276										A	151855998	C	A	151855998	4	1	24	1	0	0	0	0	0	1	0	0	9622	864	30	3	3179	3	MLL3	7	151855998	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2343597	151855998	7282665	89	6803										
HNF4G	3174	broad.mit.edu	37	chr8	76465276	76465276	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	taatgcttttcttaatactaGatctcagtctcaagccctgg	6	10	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr8:76465276G>A	uc003yaq.2	+	6	619	c.349_splice	c.e6-1	p.I117_splice	HNF4G_uc003yar.2_Splice_Site_p.I154_splice	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			CTTAATACTAGATCTCAGTCT	0.348													0	0	0	0.049695	0	18	67										A	76465276	G	A	76465276	5	1	24	1	0	0	0	0	0	0	1	0	7254	956	33	1	477	1	HNF4G	8	76465276	Splice_Site	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		76465276	69898746	90	6804										
VPS13B	157680	broad.mit.edu	37	chr8	100403871	100403871	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggaagtgcccccttggcaaaGcagcaatcatatcaggcctc	10	13	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr8:100403871G>A	uc003yiv.2	+	21	3132	c.3021G>A	c.(3019-3021)AAG>AAA	p.K1007K	VPS13B_uc003yiw.2_Silent_p.K1007K|VPS13B_uc003yiu.1_Silent_p.K1007K|VPS13B_uc003yix.1_Silent_p.K477K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1007					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCTTGGCAAAGCAGCAATCAT	0.388													0	0	0	0.043863	0	18	103										A	100403871	G	A	100403871	2	1	24	1	0	0	0	0	0	0	0	1	17187	962	34	2		2	VPS13B	8	100403871	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	23938595	100403871	45960151	91	6805										
TSNARE1	203062	broad.mit.edu	37	chr8	143436064	143436064	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gctccccaggccacctccacGggcgatggatccgtatgaca	11	16	0	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr8:143436064G>A	uc003ywk.2	-	2	140	c.22C>T	c.(22-24)CGT>TGT	p.R8C	TSNARE1_uc011lju.1_Missense_Mutation_p.R8C|TSNARE1_uc003ywj.2_Missense_Mutation_p.R8C|TSNARE1_uc003ywl.3_Missense_Mutation_p.R8C	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	8					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCACCTCCACGGGCGATGGAT	0.612													0	0	0	0.0918	0	25	135										A	143436064	G	A	143436064	3	1	24	1	0	0	0	0	1	0	0	0	16627	1116	39	2	1567	2	TSNARE1	8	143436064	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	43032193	143436064	2927958	92	6806										
ZNF517	340385	broad.mit.edu	37	chr8	146033636	146033636	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctgaacgagcactaccggctCcacagcggcgagaggccata	12	14	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr8:146033636C>T	uc003zed.1	+	5	1442	c.1335C>T	c.(1333-1335)CTC>CTT	p.L445L	ZNF517_uc010mgd.1_Silent_p.L351L|ZNF517_uc003zee.1_RNA|ZNF517_uc011llm.1_Silent_p.L351L|ZNF517_uc003zef.1_Intron	NM_213605	NP_998770	Q6ZMY9	ZN517_HUMAN	zinc finger protein 517	445	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			ACTACCGGCTCCACAGCGGCG	0.682													0	0	0	0.016723	0	11	13										T	146033636	C	T	146033636	2	4	24	1	0	0	0	0	0	0	0	1	17958	842	30	1		1	ZNF517	8	146033636	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2597572	146033636	330386	93	6807										
KIAA1797	54914	broad.mit.edu	37	chr9	20720513	20720513	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tatgttctcaatgggatactCaacttgattccatcaaccag	6	10	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr9:20720513C>T	uc003zog.1	+	6	630	c.267C>T	c.(265-267)CTC>CTT	p.L89L		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	89						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		ATGGGATACTCAACTTGATTC	0.408													0	0	0	0.048971	0	92	101										T	20720513	C	T	20720513	2	4	24	1	0	0	0	0	0	0	0	1	8258	813	29	1		1	KIAA1797	9	20720513	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		20720513	120492918	94	6808										
RGP1	9827	broad.mit.edu	37	chr9	35752111	35752111	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttctccctcccaatccctctCagctccaccccaggcttctg	4	21	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr9:35752111C>T	uc011lpf.1	+	8	1062	c.921C>T	c.(919-921)CTC>CTT	p.L307L	GBA2_uc003zxw.2_5'Flank|GBA2_uc011lpc.1_5'Flank|GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Silent_p.L347L	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	307										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAATCCCTCTCAGCTCCACCC	0.567													0	0	0	0.099896	0	24	16										T	35752111	C	T	35752111	2	4	24	1	0	0	0	0	0	0	0	1	13284	813	29	1		1	RGP1	9	35752111	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	15031598	35752111	105461320	95	6809										
RGP1	9827	broad.mit.edu	37	chr9	35752709	35752709	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cgagaaccaggattggtactCctaccccctgtggaacagcc	10	14	0	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr9:35752709C>G	uc011lpf.1	+	9	1155	c.1014C>G	c.(1012-1014)CTC>CTG	p.L338L	GBA2_uc011lpd.1_5'Flank|RGP1_uc011lpe.1_Silent_p.L378L	NM_001080496	NP_001073965	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog	338										ovary(1)	1	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GATTGGTACTCCTACCCCCTG	0.498													0	0	0	0.083992	0	22	20										G	35752709	C	G	35752709	2	3	24	1	0	0	0	0	0	0	0	1	13284	842	30	1		1	RGP1	9	35752709	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	598	35752709	105460722	96	6810										
ZNF189	7743	broad.mit.edu	37	chr9	104170392	104170392	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gataaacaaagagggatcttCctatgggaaataccaaggga	11	6	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr9:104170392C>G	uc004bbh.1	+	3	618	c.342C>G	c.(340-342)TTC>TTG	p.F114L	ZNF189_uc004bbg.1_Missense_Mutation_p.F72L|ZNF189_uc004bbi.1_Missense_Mutation_p.F100L|ZNF189_uc011lvk.1_Missense_Mutation_p.F99L	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	114					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				GAGGGATCTTCCTATGGGAAA	0.378													0	0	0	0.055883	0	22	16										G	104170392	C	G	104170392	3	3	24	1	0	0	0	0	1	0	0	0	17751	854	30	1	352	1	ZNF189	9	104170392	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	68417683	104170392	37043039	97	6811										
PHF19	26147	broad.mit.edu	37	chr9	123620306	123620306	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cgagccaacacctggtacttCtccccacaggccaaccgccc	7	20	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr9:123620306C>T	uc004bks.1	-	15	1912	c.1659G>A	c.(1657-1659)GAG>GAA	p.E553E	PHF19_uc011lyf.1_Silent_p.E344E|PHF19_uc004bkr.2_RNA	NM_015651	NP_056466	Q5T6S3	PHF19_HUMAN	PHD finger protein 19 isoform a	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|breast(1)	2						CCTGGTACTTCTCCCCACAGG	0.572													0	0	0	0.048971	0	53	36										T	123620306	C	T	123620306	2	4	24	1	0	0	0	0	0	0	0	1	11829	912	32	1		1	PHF19	9	123620306	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	19449914	123620306	17593125	98	6812										
SNAPC4	6621	broad.mit.edu	37	chr9	139273744	139273744	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgagccggcacgtttgggaaGaggtggcctgtggggaggaa	20	6	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr9:139273744G>C	uc004chh.2	-	21	2544	c.2535C>G	c.(2533-2535)CTC>CTG	p.L845L		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	845					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTTTGGGAAGAGGTGGCCTG	0.637													0	0	0	0.09319	0	13	17										C	139273744	G	C	139273744	2	2	24	1	0	0	0	0	0	0	0	1	14837	929	33	1		1	SNAPC4	9	139273744	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	15653438	139273744	1939687	99	6813										
MTPAP	55149	broad.mit.edu	37	chr10	30602779	30602779	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtaaaatccaggcactttctCgggccaaatctacaaatttt	6	10	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr10:30602779C>T	uc001iva.3	-	9	1571	c.1508G>A	c.(1507-1509)CGA>CAA	p.R503Q	MTPAP_uc001ivb.3_Missense_Mutation_p.R633Q	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	503					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						GGCACTTTCTCGGGCCAAATC	0.428													0	0	0	0.048971	0	57	141										T	30602779	C	T	30602779	3	4	24	1	0	0	0	0	1	0	0	0	9956	884	31	1	244	1	MTPAP	10	30602779	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		30602779	104931968	100	6814										
DUPD1	338599	broad.mit.edu	37	chr10	76797697	76797697	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggagctgcttcaaaaagcccCggttcgggaggacgcagcgg	16	11	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr10:76797697C>T	uc001jwq.1	-	3	560	c.560G>A	c.(559-561)CGG>CAG	p.R187Q		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	187	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CAAAAAGCCCCGGTTCGGGAG	0.642													0	0	0	0.045705	0	32	87										T	76797697	C	T	76797697	3	4	24	1	0	0	0	0	1	0	0	0	4804	652	23	2	106	2	DUPD1	10	76797697	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	46194918	76797697	58737050	101	6815										
MINPP1	9562	broad.mit.edu	37	chr10	89268152	89268152	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgagattttttgatcactgtGagaagtttttaactgaagta	9	3	1	4			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr10:89268152G>C	uc001keu.2	+	2	1147	c.697G>C	c.(697-699)GAG>CAG	p.E233Q	MINPP1_uc009xtf.1_RNA|MINPP1_uc001kev.2_Missense_Mutation_p.E233Q	NM_004897	NP_004888	Q9UNW1	MINP1_HUMAN	multiple inositol polyphosphate histidine	233					bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			urinary_tract(1)	1		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)		TGATCACTGTGAGAAGTTTTT	0.313													0	0	0	0.076483	0	23	38										C	89268152	G	C	89268152	3	2	24	1	0	0	0	0	1	0	0	0	9588	1291	45	1	741	1	MINPP1	10	89268152	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	12470455	89268152	46266595	102	6816										
EIF3A	8661	broad.mit.edu	37	chr10	120801973	120801973	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctctgtcctcatccagtcctCgtctaggtggtctgtcatca	8	14	6	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr10:120801973C>T	uc001ldu.2	-	19	3205	c.3059G>A	c.(3058-3060)CGA>CAA	p.R1020Q	EIF3A_uc010qsu.1_Missense_Mutation_p.R986Q|EIF3A_uc009xzg.1_Missense_Mutation_p.R59Q	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1020	Asp-rich.|10.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		ATCCAGTCCTCGTCTAGGTGG	0.587													0	0	0	0.048971	0	87	212										T	120801973	C	T	120801973	3	4	24	1	0	0	0	0	1	0	0	0	5012	884	31	1	1105	1	EIF3A	10	120801973	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	31533821	120801973	14732774	103	6817										
IRF7	3665	broad.mit.edu	37	chr11	612784	612784	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgccctctaggtgcactcggCacagccagggttccagctgc	12	15	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:612784C>A	uc001lqh.2	-	11	1743	c.1373G>T	c.(1372-1374)TGC>TTC	p.C458F	IRF7_uc009ycb.2_Missense_Mutation_p.C352F|IRF7_uc010qwf.1_Missense_Mutation_p.C457F|IRF7_uc001lqf.2_Missense_Mutation_p.C165F|IRF7_uc010qwg.1_Missense_Mutation_p.C165F|IRF7_uc001lqg.2_Missense_Mutation_p.C471F|IRF7_uc001lqi.2_Missense_Mutation_p.C429F|IRF7_uc010qwh.1_Missense_Mutation_p.C165F	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	458					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGCACTCGGCACAGCCAGGG	0.672													1	0	3.6726e-16	0.0918	3.93033e-16	22	52										A	612784	C	A	612784	3	1	24	1	0	0	0	0	1	0	0	0	7835	710	25	4	142	4	IRF7	11	612784	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		612784	134393732	104	6818										
KIF18A	81930	broad.mit.edu	37	chr11	28090880	28090880	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gagccaattagtattctcatCaaattgcttcaattcctcct	4	11	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:28090880C>G	uc001msc.2	-	11	1698	c.1516G>C	c.(1516-1518)GAT>CAT	p.D506H		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	506					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						GTATTCTCATCAAATTGCTTC	0.413													0	0	0	0.083992	0	24	58										G	28090880	C	G	28090880	3	3	24	1	0	0	0	0	1	0	0	0	8280	826	29	1	1208	1	KIF18A	11	28090880	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	27478096	28090880	106915636	105	6819										
FJX1	24147	broad.mit.edu	37	chr11	35640755	35640755	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acccggagcagattcagggcGaggccctgtcttactatctg	12	12	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:35640755G>A	uc001mwh.2	+	1	1021	c.571G>A	c.(571-573)GAG>AAG	p.E191K		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	191						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				GATTCAGGGCGAGGCCCTGTC	0.731													0	0	0	0.009096	0	3	5										A	35640755	G	A	35640755	3	1	24	1	0	0	0	0	1	0	0	0	5901	1059	37	1	573	1	FJX1	11	35640755	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	7549875	35640755	99365761	106	6820										
API5	8539	broad.mit.edu	37	chr11	43356859	43356859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cattcctccttcttataagaGcacagtaacactatcctgga	5	12	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:43356859G>A	uc010rfh.1	+	12	1483	c.1310G>A	c.(1309-1311)AGC>AAC	p.S437N	API5_uc010rfg.1_Missense_Mutation_p.S426N|API5_uc001mxf.2_Missense_Mutation_p.S437N|API5_uc010rfi.1_Missense_Mutation_p.S383N|API5_uc001mxg.2_Missense_Mutation_p.S311N	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	437					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCTTATAAGAGCACAGTAACA	0.383													0	0	0	0.036044	0	38	74										A	43356859	G	A	43356859	3	1	24	1	0	0	0	0	1	0	0	0	773	971	34	2	1356	2	API5	11	43356859	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	7716104	43356859	91649657	107	6821										
OR8K3	219473	broad.mit.edu	37	chr11	56086697	56086697	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gccctacgaaggacatggaaTaacttatgtaatatttttgt	8	6	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:56086697T>A	uc010rjf.1	+	1	915	c.915T>A	c.(913-915)AAT>AAA	p.N305K		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GGACATGGAATAACTTATGTA	0.328													0	0	0	0.058154	0	9	31										A	56086697	T	A	56086697	3	1	24	1	0	0	0	0	1	0	0	0	11244	1403	49	5	917	5	OR8K3	11	56086697	Missense_Mutation	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	12729838	56086697	78919819	108	6822										
BEST1	7439	broad.mit.edu	37	chr11	61729849	61729849	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccatcctcccagggcaaactCaaggaccaaactactgtggc	8	15	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:61729849C>G	uc001nss.2	+	10	1803	c.1223C>G	c.(1222-1224)TCA>TGA	p.S408*	BEST1_uc010rlq.1_3'UTR|BEST1_uc010rlr.1_3'UTR|BEST1_uc010rls.1_Nonsense_Mutation_p.S36*|BEST1_uc001nsr.2_Nonsense_Mutation_p.S348*|BEST1_uc009ynt.2_RNA|BEST1_uc010rlt.1_Nonsense_Mutation_p.S348*|BEST1_uc001nst.2_Nonsense_Mutation_p.S321*|BEST1_uc010rlu.1_3'UTR|BEST1_uc010rlv.1_Nonsense_Mutation_p.S302*	NM_004183	NP_004174	O76090	BEST1_HUMAN	bestrophin 1 isoform 1	408	Cytoplasmic (Potential).				response to stimulus|transepithelial chloride transport|visual perception	basolateral plasma membrane|chloride channel complex|cytosol|membrane fraction	chloride channel activity			central_nervous_system(1)	1						AGGGCAAACTCAAGGACCAAA	0.577													0	0	0	0.062417	0	22	62										G	61729849	C	G	61729849	4	3	24	1	0	0	0	0	0	1	0	0	1404	838	29	1	1257	1	BEST1	11	61729849	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	5643152	61729849	73276667	109	6823										
METTL12	751071	broad.mit.edu	37	chr11	62433975	62433975	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	actggttctttggatacgacGaagtccaggggctcctactg	12	10	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:62433975G>A	uc001nug.1	+	3	434	c.175G>A	c.(175-177)GAA>AAA	p.E59K	C11orf48_uc001nue.2_Intron|C11orf48_uc001nuf.2_Intron|METTL12_uc001nuh.2_Silent_p.T100T|METTL12_uc010rmc.1_RNA	NM_001043229	NP_001036694	A8MUP2	MTL12_HUMAN	methyltransferase like 12 precursor	59						mitochondrion	methyltransferase activity				0						TGGATACGACGAAGTCCAGGG	0.612													0	0	0	0.048971	0	50	93										A	62433975	G	A	62433975	3	1	24	1	0	0	0	0	1	0	0	0	9496	1059	37	1	181	1	METTL12	11	62433975	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	704126	62433975	72572541	110	6824										
CTTN	2017	broad.mit.edu	37	chr11	70281229	70281229	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggggtgtgcaagggccggtaCgggctcttcccagccaacta	15	12	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:70281229C>T	uc001opv.3	+	18	1820	c.1614C>T	c.(1612-1614)TAC>TAT	p.Y538Y	CTTN_uc001opu.2_Intron|CTTN_uc001opw.3_Silent_p.Y501Y|CTTN_uc010rqm.1_Intron|CTTN_uc001opx.2_Silent_p.Y222Y	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	538	SH3.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		AGGGCCGGTACGGGCTCTTCC	0.617													0	0	0	0.045705	0	32	58										T	70281229	C	T	70281229	2	4	24	1	0	0	0	0	0	0	0	1	4044	547	19	2		2	CTTN	11	70281229	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	7847254	70281229	64725287	111	6825										
HEPHL1	341208	broad.mit.edu	37	chr11	93778916	93778916	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggctgtttacagacgcttcaCggatggaacctactccatag	10	11	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:93778916C>T	uc001pep.2	+	2	405	c.248C>T	c.(247-249)ACG>ATG	p.T83M		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	83	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGACGCTTCACGGATGGAACC	0.453													0	0	0	0.069234	0	11	34										T	93778916	C	T	93778916	3	4	24	1	0	0	0	0	1	0	0	0	7055	536	19	2	254	2	HEPHL1	11	93778916	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	23497687	93778916	41227600	112	6826										
MLL	4297	broad.mit.edu	37	chr11	118376454	118376454	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cacttaatacttcatctcacCgaactgtccccaacatcata	2	15	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:118376454C>T	uc001pta.2	+	27	9861	c.9838C>T	c.(9838-9840)CGA>TGA	p.R3280*	MLL_uc001ptb.2_Nonsense_Mutation_p.R3283*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3280					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TTCATCTCACCGAACTGTCCC	0.433			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.048971	0	49	70										T	118376454	C	T	118376454	4	4	24	1	0	0	0	0	0	1	0	0	9620	644	23	2	9944	2	MLL	11	118376454	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	24597538	118376454	16630062	113	6827										
OR10S1	219873	broad.mit.edu	37	chr11	123848195	123848195	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aagtggtacatgggtaagctGaggtgagagtcagagcccac	15	7	1	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:123848195G>C	uc001pzm.1	-	1	204	c.204C>G	c.(202-204)CTC>CTG	p.L68L		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TGGGTAAGCTGAGGTGAGAGT	0.542													0	0	0	0.02938	0	7	35										C	123848195	G	C	123848195	2	2	24	1	0	0	0	0	0	0	0	1	10918	1277	45	1		1	OR10S1	11	123848195	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	5471741	123848195	11158321	114	6828										
OR8B4	283162	broad.mit.edu	37	chr11	124294748	124294748	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggataaactcagtcactgagGagctgtttctcagagtcatt	10	8	4	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:124294748G>A	uc010sak.1	-	1	20	c.20C>T	c.(19-21)TCC>TTC	p.S7F		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGTCACTGAGGAGCTGTTTCT	0.483													0	0	0	0.02938	0	6	17										A	124294748	G	A	124294748	3	1	24	1	0	0	0	0	1	0	0	0	11229	1174	41	1	911	1	OR8B4	11	124294748	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	446553	124294748	10711768	115	6829										
CDON	50937	broad.mit.edu	37	chr11	125891384	125891384	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccaagtttctggacagcagaGagcggctcagaagtaaaata	11	8	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr11:125891384G>C	uc009zbw.2	-	3	236	c.108C>G	c.(106-108)CTC>CTG	p.L36L	CDON_uc001qdc.3_Silent_p.L36L|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Silent_p.L36L	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	36	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		GGACAGCAGAGAGCGGCTCAG	0.448													0	0	0	0.028581	0	16	33										C	125891384	G	C	125891384	2	2	24	1	0	0	0	0	0	0	0	1	3170	929	33	1		1	CDON	11	125891384	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	1596636	125891384	9115132	116	6830										
FOXM1	2305	broad.mit.edu	37	chr12	2967845	2967845	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctgggaccagttgatgttgtCagggcccagtgggtcctcgt	15	10	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:2967845C>T	uc001qlf.2	-	9	2516	c.2251G>A	c.(2251-2253)GAC>AAC	p.D751N	uc001qld.2_Intron|FOXM1_uc001qle.2_Missense_Mutation_p.D789N|FOXM1_uc001qlg.2_Missense_Mutation_p.D736N|FOXM1_uc009zea.2_Missense_Mutation_p.D736N|FOXM1_uc009zeb.2_Missense_Mutation_p.D735N	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	751					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TTGATGTTGTCAGGGCCCAGT	0.577													0	0	0	0.027356	0	26	62										T	2967845	C	T	2967845	3	4	24	1	0	0	0	0	1	0	0	0	6018	826	29	1	44	1	FOXM1	12	2967845	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		2967845	130884050	117	6831										
DYRK4	8798	broad.mit.edu	37	chr12	4722727	4722727	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aaaacaaaagatagccccacGaagcatgttcagcattcagg	8	10	2	1	rs143171709		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:4722727G>A	uc001qmx.2	+	13	1531	c.1371G>A	c.(1369-1371)ACG>ACA	p.T457T	DYRK4_uc001qmy.1_Silent_p.T456T|DYRK4_uc001qmz.1_Silent_p.T170T|DYRK4_uc001qna.1_Silent_p.T93T|DYRK4_uc010ser.1_Silent_p.T94T	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	457						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			ATAGCCCCACGAAGCATGTTC	0.473													0	0	0	0.043863	0	20	66										A	4722727	G	A	4722727	2	1	24	1	0	0	0	0	0	0	0	1	4858	1045	37	1		1	DYRK4	12	4722727	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	1754882	4722727	129129168	118	6832										
ATN1	1822	broad.mit.edu	37	chr12	7045608	7045608	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctcttccagttcttcctcctCttcctctgcctcccccttcc	2	22	4	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:7045608C>G	uc001qrw.1	+	5	1415	c.1178C>G	c.(1177-1179)TCT>TGT	p.S393C	ATN1_uc001qrx.1_Missense_Mutation_p.S393C|ATN1_uc001qry.1_Missense_Mutation_p.S392C	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	393	Poly-Ser.				cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						tcttcctcctcttcctctgcc	0.448													0	0	0	0.099896	0	24	65										G	7045608	C	G	7045608	3	3	24	1	0	0	0	0	1	0	0	0	1111	913	32	1	1192	1	ATN1	12	7045608	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2322881	7045608	126806287	119	6833										
C12orf35	55196	broad.mit.edu	37	chr12	32138214	32138214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gagttcatctaaatttagtaGaattctaactcctaaggagt	7	6	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:32138214G>A	uc001rks.2	+	4	4739	c.4325G>A	c.(4324-4326)AGA>AAA	p.R1442K	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1442										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			AAATTTAGTAGAATTCTAACT	0.358													0	0	0	0.059317	0	32	99										A	32138214	G	A	32138214	3	1	24	1	0	0	0	0	1	0	0	0	1682	942	33	1	4327	1	C12orf35	12	32138214	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	25092606	32138214	101713681	120	6834										
TMEM117	84216	broad.mit.edu	37	chr12	44781901	44781901	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tttataaacctcatgaatatGggcaatatatcggcccgggg	10	8	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:44781901G>A	uc001rod.2	+	8	1057	c.991G>A	c.(991-993)GGG>AGG	p.G331R	TMEM117_uc001roe.2_Missense_Mutation_p.G227R|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	331						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TCATGAATATGGGCAATATAT	0.368													0	0	0	0.043863	0	19	29										A	44781901	G	A	44781901	3	1	24	1	0	0	0	0	1	0	0	0	16028	1348	47	2	1017	2	TMEM117	12	44781901	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	12643687	44781901	89069994	121	6835										
MLL2	8085	broad.mit.edu	37	chr12	49424159	49424159	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gccattcaccatcttctgctGcaccgatgggggtggggtgg	15	11	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:49424159G>A	uc001rta.3	-	42	13903	c.13903C>T	c.(13903-13905)CAG>TAG	p.Q4635*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4635					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATCTTCTGCTGCACCGATGGG	0.627			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.02938	0	5	12										A	49424159	G	A	49424159	4	1	24	1	0	0	0	0	0	1	0	0	9621	1328	46	2	2762	2	MLL2	12	49424159	Nonsense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	4642258	49424159	84427736	122	6836										
CCDC60	160777	broad.mit.edu	37	chr12	119942996	119942996	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cagagcagcatgatctctgtGaaccctggctcggatgagcc	12	12	1	4			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:119942996G>T	uc001txe.2	+	7	1236	c.771G>T	c.(769-771)GTG>GTT	p.V257V	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	257										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TGATCTCTGTGAACCCTGGCT	0.577													1	0	2.79443e-65	0.048971	3.09928e-65	86	274										T	119942996	G	T	119942996	2	4	24	1	0	0	0	0	0	0	0	1	2831	1277	45	3		3	CCDC60	12	119942996	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	70518837	119942996	13908899	123	6837										
RSRC2	65117	broad.mit.edu	37	chr12	122992836	122992836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aaatttcattggattaacagCggctgggttatagtagctag	11	5	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:122992836C>T	uc001ucr.2	-	8	1110	c.964G>A	c.(964-966)GCT>ACT	p.A322T	RSRC2_uc001uco.2_Missense_Mutation_p.A91T|RSRC2_uc001ucp.2_Missense_Mutation_p.A263T|RSRC2_uc001ucq.2_Missense_Mutation_p.A90T|RSRC2_uc001ucs.2_Missense_Mutation_p.A91T|RSRC2_uc001uct.2_Missense_Mutation_p.A274T|RSRC2_uc001ucu.2_Missense_Mutation_p.A323T	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	322										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		GGATTAACAGCGGCTGGGTTA	0.448													0	0	0	0.0918	0	20	97										T	122992836	C	T	122992836	3	4	24	1	0	0	0	0	1	0	0	0	13715	768	27	2	352	2	RSRC2	12	122992836	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	3049840	122992836	10859059	124	6838										
DENR	8562	broad.mit.edu	37	chr12	123253605	123253605	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atgatgacagcatcgaagatCttggagaagtaaagaagtga	12	4	1	6			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr12:123253605C>A	uc001uda.2	+	8	713	c.577C>A	c.(577-579)CTT>ATT	p.L193I	DENR_uc010tag.1_Intron|DENR_uc001udb.2_Missense_Mutation_p.L147I	NM_003677	NP_003668	O43583	DENR_HUMAN	density-regulated protein	193							protein binding|translation initiation factor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.28e-05)|Epithelial(86;6.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.199)		CATCGAAGATCTTGGAGAAGT	0.318													1	0	7.34454e-26	0.048971	8.00031e-26	45	133										A	123253605	C	A	123253605	3	1	24	1	0	0	0	0	1	0	0	0	4438	913	32	3	603	3	DENR	12	123253605	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	260769	123253605	10598290	125	6839										
FLT1	2321	broad.mit.edu	37	chr13	28897021	28897021	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acgctatctagtcttggtttCttgccttgttccaggcctgg	10	11	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr13:28897021C>T	uc001usb.3	-	21	3144	c.2859G>A	c.(2857-2859)AAG>AAA	p.K953K	FLT1_uc010aap.2_5'Flank|FLT1_uc010aaq.2_Silent_p.K78K|FLT1_uc001usa.3_Silent_p.K171K	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	953	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTCTTGGTTTCTTGCCTTGTT	0.493													0	0	0	0.048971	0	66	151										T	28897021	C	T	28897021	2	4	24	1	0	0	0	0	0	0	0	1	5941	912	32	1		1	FLT1	13	28897021	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		28897021	86272857	126	6840										
NBEA	26960	broad.mit.edu	37	chr13	35619479	35619479	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aattattatcagttcttaatCagatgccacagagacacggt	7	8	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr13:35619479C>T	uc001uvb.2	+	5	870	c.664C>T	c.(664-666)CAG>TAG	p.Q222*		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	222						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AGTTCTTAATCAGATGCCACA	0.323													0	0	0	0.02938	0	7	14										T	35619479	C	T	35619479	4	4	24	1	0	0	0	0	0	1	0	0	10187	827	29	1	678	1	NBEA	13	35619479	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	6722458	35619479	79550399	127	6841										
ENOX1	55068	broad.mit.edu	37	chr13	43935581	43935581	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggatcaaagcctgggacacaGattgagtctgtaaagtatac	11	7	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr13:43935581G>A	uc001uza.3	-	6	516	c.216C>T	c.(214-216)ATC>ATT	p.I72I	ENOX1_uc001uzb.3_Silent_p.I72I|ENOX1_uc001uzc.3_Silent_p.I72I|ENOX1_uc010tfm.1_5'Flank	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	72					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CTGGGACACAGATTGAGTCTG	0.413													0	0	0	0.055883	0	20	52										A	43935581	G	A	43935581	2	1	24	1	0	0	0	0	0	0	0	1	5126	932	33	1		1	ENOX1	13	43935581	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	8316102	43935581	71234297	128	6842										
KPNA3	3839	broad.mit.edu	37	chr13	50306520	50306520	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tacttacttatcatccctttCtagacatttgactagaattg	4	9	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr13:50306520C>G	uc001vdj.2	-	6	785	c.370G>C	c.(370-372)GAA>CAA	p.E124Q		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	124	ARM 2.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		TCATCCCTTTCTAGACATTTG	0.308													0	0	0	0.0918	0	25	64										G	50306520	C	G	50306520	3	3	24	1	0	0	0	0	1	0	0	0	8431	922	32	1	1243	1	KPNA3	13	50306520	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	6370939	50306520	64863358	129	6843										
NIN	51199	broad.mit.edu	37	chr14	51226630	51226630	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gagctcttttcttaactcctCtttctcaagagtgtgtttct	6	10	5	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:51226630C>T	uc001wym.2	-	17	2535	c.2344G>A	c.(2344-2346)GAG>AAG	p.E782K	NIN_uc001wyi.2_Missense_Mutation_p.E782K|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.E782K|NIN_uc010tqp.1_Missense_Mutation_p.E788K|NIN_uc001wyo.2_Missense_Mutation_p.E782K	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	782	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CTTAACTCCTCTTTCTCAAGA	0.507			T	PDGFRB	MPD								0	0	0	0.048971	0	111	223										T	51226630	C	T	51226630	3	4	24	1	0	0	0	0	1	0	0	0	10417	922	32	1	4265	1	NIN	14	51226630	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		51226630	56122910	130	6844										
SLC38A6	145389	broad.mit.edu	37	chr14	61486269	61486269	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcttttacagttggtggtggCaggcaccataataattcaga	10	7	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:61486269C>A	uc001xfg.1	+	5	490	c.374C>A	c.(373-375)GCA>GAA	p.A125E	SLC38A6_uc001xfh.1_Missense_Mutation_p.A125E|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Missense_Mutation_p.A102E	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	125	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TTGGTGGTGGCAGGCACCATA	0.313													1	0	2.13384e-23	0.048971	2.31403e-23	44	105										A	61486269	C	A	61486269	3	1	24	1	0	0	0	0	1	0	0	0	14608	710	25	4	392	4	SLC38A6	14	61486269	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	10259639	61486269	45863271	131	6845										
SMOC1	64093	broad.mit.edu	37	chr14	70459181	70459181	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tggagacccagccggtgttcGatggagatggtaagatcttg	15	7	1	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:70459181G>A	uc001xls.1	+	6	827	c.574G>A	c.(574-576)GAT>AAT	p.D192N	SMOC1_uc001xlt.1_Missense_Mutation_p.D192N	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	192					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		GCCGGTGTTCGATGGAGATGG	0.413													0	0	0	0.080935	0	11	67										A	70459181	G	A	70459181	3	1	24	1	0	0	0	0	1	0	0	0	14801	1058	37	1	596	1	SMOC1	14	70459181	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	8972912	70459181	36890359	132	6846										
C14orf159	80017	broad.mit.edu	37	chr14	91681828	91681828	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gctgtccacagtcagtacctGaggaaagcagtcggaccctc	11	13	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:91681828G>A	uc001xzb.2	+	15	2397	c.1629G>A	c.(1627-1629)CTG>CTA	p.L543L	C14orf159_uc001xyx.2_Silent_p.L491L|C14orf159_uc001xyw.2_Silent_p.L548L|C14orf159_uc001xzc.2_Silent_p.L543L|C14orf159_uc001xza.2_Silent_p.L548L|C14orf159_uc001xyv.2_Silent_p.L508L|C14orf159_uc001xyz.2_Silent_p.L419L|C14orf159_uc001xze.2_Silent_p.L543L	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	543						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GTCAGTACCTGAGGAAAGCAG	0.567													0	0	0	0.048971	0	44	126										A	91681828	G	A	91681828	2	1	24	1	0	0	0	0	0	0	0	1	1755	1277	45	1		1	C14orf159	14	91681828	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	21222647	91681828	15667712	133	6847										
GPR68	8111	broad.mit.edu	37	chr14	91700960	91700960	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gtcagcagctccttggcccaGatgaccacgctgacgccgac	11	16	1	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:91700960G>A	uc001xzg.2	-	2	776	c.435C>T	c.(433-435)ATC>ATT	p.I145I	GPR68_uc001xzh.2_Silent_p.I155I	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	145	Helical; Name=4; (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		CCTTGGCCCAGATGACCACGC	0.627													0	0	0	0.080935	0	12	29										A	91700960	G	A	91700960	2	1	24	1	0	0	0	0	0	0	0	1	6707	932	33	1		1	GPR68	14	91700960	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	19132	91700960	15648580	134	6848										
TRIP11	9321	broad.mit.edu	37	chr14	92506013	92506013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccaatccggagccgaggcccCcaagccaggacgacatcgcg	12	17	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:92506013C>T	uc001xzy.2	-	1	805	c.17G>A	c.(16-18)GGG>GAG	p.G6E	TRIP11_uc001xzz.3_RNA	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	6					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GCCGAGGCCCCCAAGCCAGGA	0.577			T	PDGFRB	AML								0	0	0	0.038147	0	6	15										T	92506013	C	T	92506013	3	4	24	1	0	0	0	0	1	0	0	0	16552	623	22	2	6006	2	TRIP11	14	92506013	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	805053	92506013	14843527	135	6849										
PLD4	122618	broad.mit.edu	37	chr14	105397201	105397201	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ctccccaaaacctggcctcaGaacttctcatctcacttcaa	3	17	4	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr14:105397201G>A	uc001ypu.1	+	7	981	c.840G>A	c.(838-840)CAG>CAA	p.Q280Q	PLD4_uc010tyl.1_Silent_p.Q287Q	NM_138790	NP_620145	Q96BZ4	PLD4_HUMAN	phospholipase D4	280					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|skin(1)	2		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	CCTGGCCTCAGAACTTCTCAT	0.567													0	0	0	0.048971	0	68	156										A	105397201	G	A	105397201	2	1	24	1	0	0	0	0	0	0	0	1	12048	933	33	1		1	PLD4	14	105397201	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	12891188	105397201	1952339	136	6850										
BUB1B	701	broad.mit.edu	37	chr15	40500941	40500941	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcaaatgtcttcaaattcctGagaaactagaacttactaat	4	8	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:40500941G>A	uc001zkx.3	+	16	2325	c.2113G>A	c.(2113-2115)GAG>AAG	p.E705K		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	705					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TCAAATTCCTGAGAAACTAGA	0.423			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.020292	0	15	57										A	40500941	G	A	40500941	3	1	24	1	0	0	0	0	1	0	0	0	1571	1291	45	1	2175	1	BUB1B	15	40500941	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		40500941	62030451	137	6851										
INO80	54617	broad.mit.edu	37	chr15	41388034	41388034	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cagaagtttcaccaagcaatGaatttggaggttcttcctta	8	8	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:41388034G>A	uc001zni.2	-	3	449	c.236C>T	c.(235-237)TCA>TTA	p.S79L	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	79	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						ACCAAGCAATGAATTTGGAGG	0.433													0	0	0	0.099896	0	27	71										A	41388034	G	A	41388034	3	1	24	1	0	0	0	0	1	0	0	0	7746	1294	45	1	4570	1	INO80	15	41388034	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	887093	41388034	61143358	138	6852										
NUSAP1	51203	broad.mit.edu	37	chr15	41657737	41657737	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agtcagagtaccttgggtctGaaggggtcactcaagcgctc	13	10	4	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:41657737G>C	uc001zns.3	+	7	1028	c.798G>C	c.(796-798)CTG>CTC	p.L266L	NUSAP1_uc001znq.3_Silent_p.L71L|NUSAP1_uc001znr.3_Silent_p.L265L|NUSAP1_uc010bce.2_Silent_p.L266L|NUSAP1_uc001znt.3_Silent_p.L251L|NUSAP1_uc001znv.3_Silent_p.L264L|NUSAP1_uc001znu.3_Silent_p.L265L|NUSAP1_uc010ucw.1_Silent_p.L242L|NUSAP1_uc001znw.3_Silent_p.L70L	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	266	Interaction with microtubules (By similarity).				cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		CCTTGGGTCTGAAGGGGTCAC	0.502													0	0	0	0.021553	0	5	26										C	41657737	G	C	41657737	2	2	24	1	0	0	0	0	0	0	0	1	10778	1277	45	1		1	NUSAP1	15	41657737	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	269703	41657737	60873655	139	6853										
LIPC	3990	broad.mit.edu	37	chr15	58861007	58861007	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgaaataaagtctaaaacatCaaagcgaaagatcagatgag	8	5	3	4			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:58861007C>G	uc010bga.1	+	11	2089	c.1481C>G	c.(1480-1482)TCA>TGA	p.S494*	LIPC_uc002afa.1_Nonsense_Mutation_p.S494*|LIPC_uc010ugy.1_Nonsense_Mutation_p.S433*	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	494					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TCTAAAACATCAAAGCGAAAG	0.348													0	0	0	0.047766	0	8	28										G	58861007	C	G	58861007	4	3	24	1	0	0	0	0	0	1	0	0	8820	838	29	1	1515	1	LIPC	15	58861007	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	17203270	58861007	43670385	140	6854										
FAM63B	54629	broad.mit.edu	37	chr15	59146724	59146724	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tccatcaagtggaagacaatCtgggaatagtgaacgtaaac	10	7	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:59146724C>G	uc002afj.2	+	9	1983	c.1781C>G	c.(1780-1782)TCT>TGT	p.S594C	FAM63B_uc002afi.2_Missense_Mutation_p.S593C|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	594										central_nervous_system(1)	1						GGAAGACAATCTGGGAATAGT	0.378													0	0	0	0.069288	0	22	59										G	59146724	C	G	59146724	3	3	24	1	0	0	0	0	1	0	0	0	5597	913	32	1	1815	1	FAM63B	15	59146724	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	285717	59146724	43384668	141	6855										
CILP	8483	broad.mit.edu	37	chr15	65491367	65491367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tagaaggagttggtggcattCtgaaagcaatcatggggcag	15	5	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:65491367C>G	uc002aon.2	-	9	1438	c.1257G>C	c.(1255-1257)CAG>CAC	p.Q419H		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	419					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TGGTGGCATTCTGAAAGCAAT	0.507													0	0	0	0.037714	0	27	95										G	65491367	C	G	65491367	3	3	24	1	0	0	0	0	1	0	0	0	3429	912	32	1	2301	1	CILP	15	65491367	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	6344643	65491367	37040025	142	6856										
TLE3	7090	broad.mit.edu	37	chr15	70346924	70346924	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccttgatgcggggcgtgggcGaggccaggtcccagatggtg	19	10	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:70346924G>A	uc002asm.2	-	16	2807	c.1688C>T	c.(1687-1689)TCG>TTG	p.S563L	TLE3_uc002ask.2_Missense_Mutation_p.S490L|TLE3_uc002asl.2_Missense_Mutation_p.S563L|TLE3_uc010ukd.1_Missense_Mutation_p.S553L|TLE3_uc010bik.1_Missense_Mutation_p.S144L|TLE3_uc010bil.1_Missense_Mutation_p.S560L|TLE3_uc002asn.2_Missense_Mutation_p.S551L|TLE3_uc002asp.2_Missense_Mutation_p.S555L|TLE3_uc002aso.2_Missense_Mutation_p.S558L	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	563	WD 2.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						GGGCGTGGGCGAGGCCAGGTC	0.652													0	0	0	0.09319	0	13	30										A	70346924	G	A	70346924	3	1	24	1	0	0	0	0	1	0	0	0	15937	1059	37	1	650	1	TLE3	15	70346924	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	4855557	70346924	32184468	143	6857										
CPEB1	64506	broad.mit.edu	37	chr15	83296112	83296112	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atcttttatccttcctgcttCttcttcctagacacagaaaa	3	12	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr15:83296112C>G	uc002bit.2	-	2	339	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	CPEB1_uc002biu.2_Missense_Mutation_p.E35Q|CPEB1_uc010uof.1_5'UTR|CPEB1_uc002biv.2_Missense_Mutation_p.E8Q	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	8					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			CTTCCTGCTTCTTCTTCCTAG	0.398													0	0	0	0.058154	0	10	41										G	83296112	C	G	83296112	3	3	24	1	0	0	0	0	1	0	0	0	3800	922	32	1	1722	1	CPEB1	15	83296112	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	12949188	83296112	19235280	144	6858										
SOLH	6650	broad.mit.edu	37	chr16	601635	601635	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cacggcagcagtgagggtgtCttctggatggagtacggcga	17	8	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:601635C>T	uc002chi.2	+	9	2679	c.2316C>T	c.(2314-2316)GTC>GTT	p.V772V	SOLH_uc002chj.2_5'Flank	NM_005632	NP_005623	O75808	CAN15_HUMAN	small optic lobes	772	Calpain catalytic.				proteolysis	intracellular	calcium-dependent cysteine-type endopeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)	2		Hepatocellular(780;0.00335)				GTGAGGGTGTCTTCTGGATGG	0.672													0	0	0	0.050027	0	30	55										T	601635	C	T	601635	2	4	24	1	0	0	0	0	0	0	0	1	14925	900	32	1		1	SOLH	16	601635	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		601635	89753118	145	6859										
PKD1	5310	broad.mit.edu	37	chr16	2155925	2155925	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gacgtgctggggatcggcctGccgcagcagccctgggagca	17	13	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:2155925G>A	uc002cos.1	-	20	8013	c.7804C>T	c.(7804-7806)CAG>TAG	p.Q2602*	PKD1_uc002cot.1_Nonsense_Mutation_p.Q2602*|PKD1_uc010bse.1_5'Flank	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2602	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GGATCGGCCTGCCGCAGCAGC	0.657													0	0	0	0.043863	0	20	51										A	2155925	G	A	2155925	4	1	24	1	0	0	0	0	0	1	0	0	11963	1328	46	2	5215	2	PKD1	16	2155925	Nonsense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	1554290	2155925	88198828	146	6860										
SRRM2	23524	broad.mit.edu	37	chr16	2813979	2813979	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcatatcctacagtggactcGaattctctcttggggcagag	10	10	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:2813979G>A	uc002crk.2	+	11	3999	c.3450G>A	c.(3448-3450)TCG>TCA	p.S1150S	SRRM2_uc002crj.1_Silent_p.S1054S|SRRM2_uc002crl.1_Silent_p.S1150S|SRRM2_uc010bsu.1_Silent_p.S1054S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1150	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CAGTGGACTCGAATTCTCTCT	0.478													0	0	0	0.064281	0	35	129										A	2813979	G	A	2813979	2	1	24	1	0	0	0	0	0	0	0	1	15168	1045	37	1		1	SRRM2	16	2813979	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	658054	2813979	87540774	147	6861										
CREBBP	1387	broad.mit.edu	37	chr16	3781375	3781375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gagggtgaggaaggcgtcgcGcccatccatgaggtcacagc	16	11	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:3781375G>A	uc002cvv.2	-	30	5194	c.4990C>T	c.(4990-4992)CGC>TGC	p.R1664C	CREBBP_uc002cvw.2_Missense_Mutation_p.R1626C	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1664	Interaction with TRERF1.		R -> H (in RSTS1; abolishes acetyltransferase activity).		cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAGGCGTCGCGCCCATCCATG	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.021553	0	6	10										A	3781375	G	A	3781375	3	1	24	1	0	0	0	0	1	0	0	0	3861	1087	38	2	2346	2	CREBBP	16	3781375	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	967396	3781375	86573378	148	6862										
CCDC135	84229	broad.mit.edu	37	chr16	57755605	57755605	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gaggatgaggataagagcttCgacatgccccactcgtgggt	14	9	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:57755605C>A	uc002emi.2	+	9	1322	c.1233C>A	c.(1231-1233)TTC>TTA	p.F411L	CCDC135_uc002emj.2_Missense_Mutation_p.F411L|CCDC135_uc002emk.2_Missense_Mutation_p.F346L	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	411						cytoplasm				central_nervous_system(1)	1						ATAAGAGCTTCGACATGCCCC	0.532													1	0	6.38683e-12	0.037714	6.68836e-12	22	63										A	57755605	C	A	57755605	3	1	24	1	0	0	0	0	1	0	0	0	2769	883	31	3	1263	3	CCDC135	16	57755605	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	53974230	57755605	32599148	149	6863										
CDH3	1001	broad.mit.edu	37	chr16	68718667	68718667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggtccaggagggcatccccaCtggggagcctgtgtgtgtct	16	11	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:68718667C>T	uc002ewf.2	+	10	2496	c.1364C>T	c.(1363-1365)ACT>ATT	p.T455I	CDH3_uc010vli.1_Missense_Mutation_p.T400I	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	455	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		GGCATCCCCACTGGGGAGCCT	0.552													0	0	0	0.048971	0	61	214										T	68718667	C	T	68718667	3	4	24	1	0	0	0	0	1	0	0	0	3111	565	20	2	1402	2	CDH3	16	68718667	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	10963062	68718667	21636086	150	6864										
KIAA0182	23199	broad.mit.edu	37	chr16	85689517	85689517	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gcgcatgtctggcctcagcgCggagaggtaagtgcgtctcg	16	11	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:85689517C>T	uc002fix.2	+	6	1057	c.983C>T	c.(982-984)GCG>GTG	p.A328V	KIAA0182_uc002fiw.2_Missense_Mutation_p.A224V|KIAA0182_uc002fiy.2_Missense_Mutation_p.A255V	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	328	Potential.						protein binding			large_intestine(3)|ovary(1)|skin(1)	5						GGCCTCAGCGCGGAGAGGTAA	0.657													0	0	0	0.047766	0	8	26										T	85689517	C	T	85689517	3	4	24	1	0	0	0	0	1	0	0	0	8159	768	27	2	1005	2	KIAA0182	16	85689517	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	16970850	85689517	4665236	151	6865										
KLHDC4	54758	broad.mit.edu	37	chr16	87743101	87743101	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	accggggctgccccgccgagCctggcgcggtgagcacctgc	16	17	0	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:87743101C>A	uc002fki.2	-	10	1263	c.1217G>T	c.(1216-1218)GGC>GTC	p.G406V	KLHDC4_uc002fkh.1_RNA|KLHDC4_uc010cht.1_Intron|KLHDC4_uc002fkj.2_Missense_Mutation_p.G375V|KLHDC4_uc002fkk.2_Missense_Mutation_p.G225V|KLHDC4_uc002fkl.2_Missense_Mutation_p.G349V|KLHDC4_uc010chu.1_Missense_Mutation_p.G225V	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	406										pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CCCCGCCGAGCCTGGCGCGGT	0.697													1	0	3.51602e-12	0.049695	3.69788e-12	13	37										A	87743101	C	A	87743101	3	1	24	1	0	0	0	0	1	0	0	0	8358	739	26	4	353	4	KLHDC4	16	87743101	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2053584	87743101	2611652	152	6866										
TCF25	22980	broad.mit.edu	37	chr16	89977011	89977011	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tctttcaggctaagtcctatCagccatggaaacaccattgc	7	12	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr16:89977011C>G	uc002fpb.2	+	17	1894	c.1812C>G	c.(1810-1812)ATC>ATG	p.I604M	TCF25_uc002fpc.2_Missense_Mutation_p.Q409E|uc010ciy.1_5'Flank	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	604					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TAAGTCCTATCAGCCATGGAA	0.557											OREG0024057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.069288	0	21	90										G	89977011	C	G	89977011	3	3	24	1	0	0	0	0	1	0	0	0	15690	816	29	1	1878	1	TCF25	16	89977011	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2233910	89977011	377742	153	6867										
SGSM2	9905	broad.mit.edu	37	chr17	2265472	2265472	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	agcgggaaggccccggccctCagccctcaggccttgaaaca	12	16	2	1	rs113450178		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:2265472C>T	uc002fun.3	+	4	541	c.366C>T	c.(364-366)CTC>CTT	p.L122L	SGSM2_uc002fum.3_Silent_p.L122L|SGSM2_uc010vqw.1_Silent_p.L122L	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	122	RUN.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CCCCGGCCCTCAGCCCTCAGG	0.642													0	0	0	0.048971	0	109	125										T	2265472	C	T	2265472	2	4	24	1	0	0	0	0	0	0	0	1	14223	813	29	1		1	SGSM2	17	2265472	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		2265472	78929738	154	6868										
EIF5A	1984	broad.mit.edu	37	chr17	7214697	7214697	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	catccaggatgggtacctatCactgctccaggacagcgggg	13	12	1	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:7214697C>A	uc010vtv.1	+	4	536	c.299C>A	c.(298-300)TCA>TAA	p.S100*	EIF5A_uc002gfr.2_Nonsense_Mutation_p.S130*|EIF5A_uc002gft.2_Nonsense_Mutation_p.S100*|EIF5A_uc002gfu.2_Nonsense_Mutation_p.S100*	NM_001970	NP_001961	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	100					induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding				0						GGGTACCTATCACTGCTCCAG	0.562													1	0	1.66031e-10	0.0918	1.72389e-10	26	136										A	7214697	C	A	7214697	4	1	24	1	0	0	0	0	0	1	0	0	5041	838	29	3	403	3	EIF5A	17	7214697	Nonsense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	4949225	7214697	73980513	155	6869										
DNAH2	146754	broad.mit.edu	37	chr17	7702000	7702000	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aacatcctcagctcaggcgaGgtgcccaatctctacaagcc	8	15	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:7702000G>A	uc002giu.1	+	54	8537	c.8523G>A	c.(8521-8523)GAG>GAA	p.E2841E		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2841	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GCTCAGGCGAGGTGCCCAATC	0.512													0	0	0	0.048971	0	82	74										A	7702000	G	A	7702000	2	1	24	1	0	0	0	0	0	0	0	1	4602	991	35	2		2	DNAH2	17	7702000	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	487303	7702000	73493210	156	6870										
RPL26	6154	broad.mit.edu	37	chr17	8285553	8285553	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggaagacataatcttccttcGaatgtgggaaggtgcattga	12	6	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:8285553G>C	uc002glh.1	-	2	172	c.76C>G	c.(76-78)CGA>GGA	p.R26G		NM_000987	NP_000978	P61254	RL26_HUMAN	ribosomal protein L26	26					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						ATCTTCCTTCGAATGTGGGAA	0.418													0	0	0	0.024245	0	16	89										C	8285553	G	C	8285553	3	2	24	1	0	0	0	0	1	0	0	0	13573	1066	37	1	373	1	RPL26	17	8285553	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	583553	8285553	72909657	157	6871										
MYH1	4619	broad.mit.edu	37	chr17	10419637	10419637	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gagggttcatggggaagactTggtcatctttcactgttaca	12	7	4	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:10419637T>G	uc002gmo.2	-	4	321	c.227A>C	c.(226-228)CAA>CCA	p.Q76P	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	76	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGGGAAGACTTGGTCATCTTT	0.463													0	0	0	0.048971	0	56	232										G	10419637	T	G	10419637	3	3	24	1	0	0	0	0	1	0	0	0	10029	1812	63	5	5740	5	MYH1	17	10419637	Missense_Mutation	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	2134084	10419637	70775573	158	6872										
MYH2	4620	broad.mit.edu	37	chr17	10442618	10442618	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttgatgcgggcaaccatccaCaggaacatcttctcgtagac	9	12	2	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:10442618C>T	uc010coi.2	-	14	1448	c.1320G>A	c.(1318-1320)CTG>CTA	p.L440L	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.L440L|MYH2_uc010coj.2_Silent_p.L440L	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	440	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CAACCATCCACAGGAACATCT	0.473													0	0	0	0.048971	0	47	247										T	10442618	C	T	10442618	2	4	24	1	0	0	0	0	0	0	0	1	10035	465	17	2		2	MYH2	17	10442618	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	22981	10442618	70752592	159	6873										
ZNF207	7756	broad.mit.edu	37	chr17	30685544	30685544	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	acataaagaaacaatagatgCcgtaccaaatgcaatacctg	6	9	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:30685544C>G	uc002hhh.3	+	3	339	c.191C>G	c.(190-192)GCC>GGC	p.A64G	ZNF207_uc002hhj.3_Missense_Mutation_p.A64G|ZNF207_uc002hhi.3_Missense_Mutation_p.A64G|ZNF207_uc010csz.2_Missense_Mutation_p.A67G|ZNF207_uc002hhk.1_Missense_Mutation_p.A64G|ZNF207_uc002hhl.1_5'Flank	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	64						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			ACAATAGATGCCGTACCAAAT	0.318													0	0	0	0.099896	0	24	90										G	30685544	C	G	30685544	3	3	24	1	0	0	0	0	1	0	0	0	17762	739	26	4	201	4	ZNF207	17	30685544	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	20242926	30685544	50509666	160	6874										
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39261650	39261650	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gttctgacaccatggtcagcTcctgttgtggctccgtgtgc	12	12	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:39261650T>C	uc010wfp.1	+	1	10	c.10T>C	c.(10-12)TCC>CCC	p.S4P		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	4						keratin filament					0						CATGGTCAGCTCCTGTTGTGG	0.592													0	0	0	0.0333	0	9	28										C	39261650	T	C	39261650	3	2	24	1	0	0	0	0	1	0	0	0	8557	1551	54	5	12	5	KRTAP4-9	17	39261650	Missense_Mutation	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	8576106	39261650	41933560	161	6875										
EZH1	2145	broad.mit.edu	37	chr17	40870014	40870014	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cagcaaaaggaagcagtctgTgccacatggttctggttcaa	11	9	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:40870014T>C	uc002iaz.2	-	10	1148	c.1003A>G	c.(1003-1005)ACA>GCA	p.T335A	EZH1_uc002iba.2_Missense_Mutation_p.T326A|EZH1_uc010wgt.1_Missense_Mutation_p.T265A|EZH1_uc010wgu.1_Missense_Mutation_p.T341A|EZH1_uc010wgv.1_Missense_Mutation_p.T295A|EZH1_uc010wgw.1_Missense_Mutation_p.T196A|EZH1_uc010cyp.2_Missense_Mutation_p.T236A|EZH1_uc010cyq.2_Missense_Mutation_p.T252A|EZH1_uc010cys.2_Missense_Mutation_p.T286A|EZH1_uc010cyo.1_Intron|EZH1_uc010cyr.1_5'UTR	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	335					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		AAGCAGTCTGTGCCACATGGT	0.408													0	0	0	0.020292	0	12	57										C	40870014	T	C	40870014	3	2	24	1	0	0	0	0	1	0	0	0	5333	1696	59	5	1288	5	EZH1	17	40870014	Missense_Mutation	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	1608364	40870014	40325196	162	6876										
PLCD3	113026	broad.mit.edu	37	chr17	43195396	43195396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gcgcacggcttggaccacgtCccggaagagaatcttggagg	15	11	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:43195396C>T	uc002iib.2	-	7	1339	c.1225G>A	c.(1225-1227)GAC>AAC	p.D409N		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	409	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	TGGACCACGTCCCGGAAGAGA	0.657													0	0	0	0.038147	0	8	31										T	43195396	C	T	43195396	3	4	24	1	0	0	0	0	1	0	0	0	12032	855	30	1	1179	1	PLCD3	17	43195396	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2325382	43195396	37999814	163	6877										
PDK2	5164	broad.mit.edu	37	chr17	48174834	48174834	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccttcaccttcctcaggcagGagctgcctgtgcgcctggcc	11	17	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:48174834G>C	uc002iqc.2	+	2	270	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	PDK2_uc002iqb.2_5'UTR	NM_002611	NP_002602	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase 2 precursor	56					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(3)	3						CCTCAGGCAGGAGCTGCCTGT	0.488									Autosomal_Dominant_Polycystic_Kidney_Disease				0	0	0	0.086207	0	35	63										C	48174834	G	C	48174834	3	2	24	1	0	0	0	0	1	0	0	0	11676	1175	41	1	172	1	PDK2	17	48174834	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	4979438	48174834	33020376	164	6878										
KIF2B	84643	broad.mit.edu	37	chr17	51901324	51901324	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cagacgggaagtgggaagacGtacaccatgggtggagactt	16	7	0	3	rs139246128		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:51901324G>A	uc002iua.2	+	1	1086	c.930G>A	c.(928-930)ACG>ACA	p.T310T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	310	ATP (By similarity).|Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GTGGGAAGACGTACACCATGG	0.547													0	0	0	0.048971	0	64	70										A	51901324	G	A	51901324	2	1	24	1	0	0	0	0	0	0	0	1	8298	1132	40	2		2	KIF2B	17	51901324	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	3726490	51901324	29293886	165	6879										
OR4D1	26689	broad.mit.edu	37	chr17	56233157	56233157	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcatctggttcctcctccttCtgatctcttatactgtcatc	4	14	5	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:56233157C>T	uc010wno.1	+	1	643	c.643C>T	c.(643-645)CTG>TTG	p.L215L	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTCCTCCTTCTGATCTCTTA	0.537													0	0	0	0.048971	0	56	56										T	56233157	C	T	56233157	2	4	24	1	0	0	0	0	0	0	0	1	11053	912	32	1		1	OR4D1	17	56233157	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	4331833	56233157	24962053	166	6880										
TRIM37	4591	broad.mit.edu	37	chr17	57148206	57148206	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggtaaagtctggtggaacagGagtggtaacaaaagatgcca	14	5	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:57148206G>A	uc002iwy.3	-	9	1231	c.787C>T	c.(787-789)CCT>TCT	p.P263S	TRIM37_uc002iwz.3_Missense_Mutation_p.P263S|TRIM37_uc002ixa.3_Missense_Mutation_p.P141S|TRIM37_uc010woc.1_Missense_Mutation_p.P229S	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	263						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GGTGGAACAGGAGTGGTAACA	0.363									Mulibrey_Nanism				0	0	0	0.083992	0	25	94										A	57148206	G	A	57148206	3	1	24	1	0	0	0	0	1	0	0	0	16508	1174	41	1	2179	1	TRIM37	17	57148206	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	915049	57148206	24047004	167	6881										
SYNGR2	9144	broad.mit.edu	37	chr17	76167700	76167700	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gactctgtgagggcagccatCaccttcagcttcttttccat	8	13	4	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:76167700C>T	uc002juu.1	+	3	474	c.447C>T	c.(445-447)ATC>ATT	p.I149I	SYNGR2_uc002jut.2_Silent_p.I149I|SYNGR2_uc002juv.1_Intron|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	149	MARVEL.|Helical; (Potential).					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			GGGCAGCCATCACCTTCAGCT	0.612													0	0	0	0.037714	0	23	51										T	76167700	C	T	76167700	2	4	24	1	0	0	0	0	0	0	0	1	15446	816	29	1		1	SYNGR2	17	76167700	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	19019494	76167700	5027510	168	6882										
BIRC5	332	broad.mit.edu	37	chr17	76219552	76219552	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttctttatttccaggcaaagGaaaccaacaataagaagaaa	6	7	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr17:76219552G>A	uc002jvg.2	+	4	467	c.346G>A	c.(346-348)GAA>AAA	p.E116K	BIRC5_uc002jvf.2_Missense_Mutation_p.E139K|BIRC5_uc002jvh.2_Silent_p.R76R|BIRC5_uc002jvi.2_RNA|EPR1_uc002jvj.1_RNA	NM_001168	NP_001159	O15392	BIRC5_HUMAN	baculoviral IAP repeat-containing protein 5	116					anti-apoptosis|apoptosis|cell division|chromosome segregation|cytokinesis|establishment of chromosome localization|G2/M transition of mitotic cell cycle|mitosis|mitotic prometaphase|positive regulation of exit from mitosis|positive regulation of mitotic cell cycle|protein complex localization|spindle checkpoint	centriole|chromosome passenger complex|chromosome, centromeric region|cytoplasm|cytoplasmic microtubule|cytosol|interphase microtubule organizing center|midbody|midbody|nuclear chromosome|spindle|spindle microtubule	caspase inhibitor activity|chaperone binding|cobalt ion binding|cofactor binding|cysteine-type endopeptidase inhibitor activity|metal ion binding|microtubule binding|protein heterodimerization activity|protein homodimerization activity|Ran GTPase binding|zinc ion binding			kidney(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.153)			CCAGGCAAAGGAAACCAACAA	0.468													0	0	0	0.0918	0	25	43										A	76219552	G	A	76219552	3	1	24	1	0	0	0	0	1	0	0	0	1437	1175	41	1	433	1	BIRC5	17	76219552	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	51852	76219552	4975658	169	6883										
C18orf10	25941	broad.mit.edu	37	chr18	34387820	34387820	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gctgactcaccatccagcttCacactccatgtcatgtggaa	7	14	3	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr18:34387820C>T	uc002kzw.1	-	3	671	c.243G>A	c.(241-243)GTG>GTA	p.V81V	C18orf10_uc002kzv.1_Silent_p.V81V|C18orf10_uc010xci.1_Silent_p.V81V|C18orf10_uc002kzx.1_Silent_p.V81V|C18orf10_uc002kzy.3_Silent_p.V81V	NM_015476	NP_056291	Q68CL5	TPGS2_HUMAN	tubulin polyglutamylase complex subunit 2	81						cytoplasm|microtubule				skin(1)	1						catccagcttcACACTCCATG	0.204													0	0	0	0.054565	0	33	66										T	34387820	C	T	34387820	2	4	24	1	0	0	0	0	0	0	0	1	1895	813	29	1		1	C18orf10	18	34387820	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		34387820	43689428	170	6884										
CELF4	56853	broad.mit.edu	37	chr18	34839222	34839222	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gatgaacaggttacagccctCgggccctgcggtgaggggag	17	10	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr18:34839222C>G	uc002lae.2	-	11	1651	c.1255G>C	c.(1255-1257)GAG>CAG	p.E419Q	CELF4_uc010dnd.1_Missense_Mutation_p.E417Q|CELF4_uc002lag.2_Intron|CELF4_uc002laf.2_Missense_Mutation_p.E413Q|CELF4_uc002lai.2_Missense_Mutation_p.E403Q	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	419	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TTACAGCCCTCGGGCCCTGCG	0.323													0	0	0	0.069234	0	9	29										G	34839222	C	G	34839222	3	3	24	1	0	0	0	0	1	0	0	0	3218	893	31	1	213	1	CELF4	18	34839222	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	451402	34839222	43238026	171	6885										
CREB3L3	84699	broad.mit.edu	37	chr19	4168351	4168351	+	Missense_Mutation	SNP	G	G	A													0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cccatttcacttggcagtacGaggagcgagtgctgaaaaaa							TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:4168351G>A	uc002lzl.2	+	6	834	c.718G>A	c.(718-720)GAG>AAG	p.E240K	CREB3L3_uc002lzm.2_Missense_Mutation_p.E230K|CREB3L3_uc010xib.1_Missense_Mutation_p.E229K|CREB3L3_uc010xic.1_Intron	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	240	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGGCAGTACGAGGAGCGAGT	0.408													0	0	0	0.020292	0	13	43										A	4168351	G	A	4168351	3	1	24	1	0	0	0	0	1	0	0	0	3858	1059	37	1	740	1	CREB3L3	19	4168351	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		4168351	54960632	172	6886	32	2								
CREB3L3	84699	broad.mit.edu	37	chr19	4168358	4168358	+	Missense_Mutation	SNP	G	G	A													0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cacttggcagtacgaggagcGagtgctgaaaaaaatccgcc							TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:4168358G>A	uc002lzl.2	+	6	841	c.725G>A	c.(724-726)CGA>CAA	p.R242Q	CREB3L3_uc002lzm.2_Missense_Mutation_p.R232Q|CREB3L3_uc010xib.1_Missense_Mutation_p.R231Q|CREB3L3_uc010xic.1_Intron	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	242	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		TACGAGGAGCGAGTGCTGAAA	0.413													0	0	0	0.016723	0	12	46										A	4168358	G	A	4168358	3	1	24	1	0	0	0	0	1	0	0	0	3858	1058	37	1	747	1	CREB3L3	19	4168358	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	7	4168358	54960625	173	6887	32	2								
SEMA6B	10501	broad.mit.edu	37	chr19	4550273	4550273	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	actgcatcccgggggctgcgCagcacccgggcctgggggtg	18	14	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:4550273C>G	uc010duc.1	-	11	1171	c.1133G>C	c.(1132-1134)TGC>TCC	p.C378S	SEMA6B_uc010dud.2_Missense_Mutation_p.C378S|SEMA6B_uc010xih.1_Missense_Mutation_p.C378S	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	378	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGGCTGCGCAGCACCCGGG	0.602													0	0	0	0.037714	0	27	76										G	4550273	C	G	4550273	3	3	24	1	0	0	0	0	1	0	0	0	14040	710	25	4	1557	4	SEMA6B	19	4550273	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	381915	4550273	54578710	174	6888										
SH2D3A	10045	broad.mit.edu	37	chr19	6760801	6760801	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atataactgtgaaccagagcCggtatgctggggaattgctc	12	8	0	2	rs143102735		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:6760801C>T	uc002mft.2	-	3	461	c.267G>A	c.(265-267)CCG>CCA	p.P89P	SH2D3A_uc010xjg.1_Intron	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	89	SH2.				JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						GAACCAGAGCCGGTATGCTGG	0.632													0	0	0	0.092188	0	32	78										T	6760801	C	T	6760801	2	4	24	1	0	0	0	0	0	0	0	1	14233	639	23	2		2	SH2D3A	19	6760801	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	2210528	6760801	52368182	175	6889										
MUC16	94025	broad.mit.edu	37	chr19	9057196	9057196	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggtgacttcagaggcagccaGtatttcaactgaggtgccac	12	10	2	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:9057196G>A	uc002mkp.2	-	3	30454	c.30250C>T	c.(30250-30252)CTG>TTG	p.L10084L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10086	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGCAGCCAGTATTTCAACT	0.473													0	0	0	0.09319	0	10	41										A	9057196	G	A	9057196	2	1	24	1	0	0	0	0	0	0	0	1	9973	1020	36	2		2	MUC16	19	9057196	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	2296395	9057196	50071787	176	6890										
MLL4	9757	broad.mit.edu	37	chr19	36221009	36221009	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcttctgccagaaacacactGatctcctggatggcaaggtg	10	11	3	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:36221009G>A	uc010eei.2	+	24	5059	c.5059G>A	c.(5059-5061)GAT>AAT	p.D1687N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1687					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAAACACACTGATCTCCTGGA	0.587													0	0	0	0.058154	0	8	21										A	36221009	G	A	36221009	3	1	24	1	0	0	0	0	1	0	0	0	9623	1290	45	1	5149	1	MLL4	19	36221009	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	27163813	36221009	22907974	177	6891										
ZNF790	388536	broad.mit.edu	37	chr19	37310567	37310567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cttcccacattctttacattCatatgttttcttaacagtgt	3	10	3	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:37310567C>G	uc002oew.2	-	5	798	c.679G>C	c.(679-681)GAA>CAA	p.E227Q	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	227	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCTTTACATTCATATGTTTTC	0.348													0	0	0	0.030593	0	27	53										G	37310567	C	G	37310567	3	3	24	1	0	0	0	0	1	0	0	0	18159	835	29	1	1235	1	ZNF790	19	37310567	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	1089558	37310567	21818416	178	6892										
AP2S1	1175	broad.mit.edu	37	chr19	47349397	47349397	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttctggatgaggataaagcgGatctgggggcagcaggagga	18	5	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:47349397G>A	uc002pft.1	-	2	186	c.6C>T	c.(4-6)ATC>ATT	p.I2I	AP2S1_uc002pfu.1_Silent_p.I2I	NM_004069	NP_004060	P53680	AP2S1_HUMAN	adaptor-related protein complex 2, sigma 1	2					axon guidance|clathrin coat assembly|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|regulation of endocytosis|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	protein transporter activity				0		all_cancers(25;1.24e-06)|all_epithelial(76;1.09e-05)|all_lung(116;0.00019)|Lung NSC(112;0.000601)|Ovarian(192;0.0221)|all_neural(266;0.0459)|Breast(70;0.128)		OV - Ovarian serous cystadenocarcinoma(262;3.86e-05)|all cancers(93;0.000107)|Epithelial(262;0.00325)|GBM - Glioblastoma multiforme(486;0.0336)		GGATAAAGCGGATCTGGGGGC	0.597													0	0	0	0.055883	0	18	50										A	47349397	G	A	47349397	2	1	24	1	0	0	0	0	0	0	0	1	743	1164	41	1		1	AP2S1	19	47349397	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	10038830	47349397	11779586	179	6893										
CRX	1406	broad.mit.edu	37	chr19	48343102	48343102	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tatcaggccagagctatggcGcctacagccccgtggatagc	12	13	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:48343102G>A	uc002phq.3	+	4	982	c.778G>A	c.(778-780)GCC>ACC	p.A260T		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	260					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GAGCTATGGCGCCTACAGCCC	0.632													0	0	0	0.048971	0	99	236										A	48343102	G	A	48343102	3	1	24	1	0	0	0	0	1	0	0	0	3902	1087	38	2	788	2	CRX	19	48343102	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	993705	48343102	10785881	180	6894										
LRRC4B	94030	broad.mit.edu	37	chr19	51022595	51022595	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccgttgaaggcgcccacctcGatcttgcgcaccaggttctt	10	15	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:51022595G>A	uc002pss.2	-	3	512	c.375C>T	c.(373-375)ATC>ATT	p.I125I		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	125	Extracellular (Potential).|LRR 2.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CGCCCACCTCGATCTTGCGCA	0.622													0	0	0	0.028581	0	16	50										A	51022595	G	A	51022595	2	1	24	1	0	0	0	0	0	0	0	1	9007	1048	37	1		1	LRRC4B	19	51022595	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	2679493	51022595	8106388	181	6895										
LILRA6	79168	broad.mit.edu	37	chr19	54745730	54745730	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ccacagggctgggcagggctGagagggtgggtttgttgtag	20	6	0	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:54745730G>A	uc002qeu.1	-	4	504	c.380C>T	c.(379-381)TCA>TTA	p.S127L	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Missense_Mutation_p.S127L|LILRA6_uc002qek.1_Missense_Mutation_p.S127L|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.S127L|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.S127L|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.S127L|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.S127L|LILRA6_uc010yep.1_Missense_Mutation_p.S127L|LILRA6_uc010yeq.1_Missense_Mutation_p.S127L|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_5'UTR	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	127	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGCAGGGCTGAGAGGGTGGG	0.562													0	0	0	0.048971	0	38	91										A	54745730	G	A	54745730	3	1	24	1	0	0	0	0	1	0	0	0	8789	1294	45	1	1085	1	LILRA6	19	54745730	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	3723135	54745730	4383253	182	6896										
ZSCAN5A	79149	broad.mit.edu	37	chr19	56733572	56733572	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tcagattcagagcgtctcctCtgttcccgctgtgagtcgaa	10	12	4	3			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr19:56733572C>T	uc002qmq.2	-	5	1029	c.863G>A	c.(862-864)AGA>AAA	p.R288K	ZSCAN5A_uc010ygi.1_Missense_Mutation_p.R171K|ZSCAN5A_uc002qmr.2_Missense_Mutation_p.R288K|ZSCAN5A_uc002qms.1_Missense_Mutation_p.R287K	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	288					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						AGCGTCTCCTCTGTTCCCGCT	0.537													0	0	0	0.048971	0	67	138										T	56733572	C	T	56733572	3	4	24	1	0	0	0	0	1	0	0	0	18235	913	32	1	631	1	ZSCAN5A	19	56733572	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	1987842	56733572	2395411	183	6897										
RIN2	54453	broad.mit.edu	37	chr20	19955572	19955572	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	actcccaacgcgaatggcacGgagcggactcggtccccccc	11	18	0	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr20:19955572G>T	uc002wro.1	+	7	939	c.903G>T	c.(901-903)ACG>ACT	p.T301T	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Silent_p.T95T	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	301					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						CGAATGGCACGGAGCGGACTC	0.607													1	0	9.70103e-10	0.069234	1.00299e-09	9	31										T	19955572	G	T	19955572	2	4	24	1	0	0	0	0	0	0	0	1	13372	1103	39	4		4	RIN2	20	19955572	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08		19955572	43069948	184	6898										
C20orf186	149954	broad.mit.edu	37	chr20	31699226	31699226	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ttctgccatccaaggaccttTtggtgctgagcgcatgagtg	12	10	1	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr20:31699226T>C	uc010zue.1	+	16	1843	c.1828T>C	c.(1828-1830)TTG>CTG	p.L610L		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	610						cytoplasm|extracellular region	lipid binding				0						CAAGGACCTTTTGGTGCTGAG	0.587													0	0	0	0.076483	0	22	47										C	31699226	T	C	31699226	2	2	24	1	0	0	0	0	0	0	0	1	2098	1838	64	5		5	C20orf186	20	31699226	Silent	SNP	T	TCGA-C4-A0F1-01A-11D-A10S-08	11743654	31699226	31326294	185	6899										
RBM12	10137	broad.mit.edu	37	chr20	34242690	34242690	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggaggaattggtggcggcggGactgtgttcattggagaggc	20	5	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr20:34242690G>T	uc002xdq.2	-	3	787	c.555C>A	c.(553-555)GTC>GTA	p.V185V	CPNE1_uc010zvj.1_5'Flank|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Silent_p.V185V|RBM12_uc002xds.2_Silent_p.V185V	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	185	Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GTGGCGGCGGGACTGTGTTCA	0.547													1	0	1.15088e-07	0.028581	1.17495e-07	14	41										T	34242690	G	T	34242690	2	4	24	1	0	0	0	0	0	0	0	1	13113	1161	41	3		3	RBM12	20	34242690	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	2543464	34242690	28782830	186	6900										
ADA	100	broad.mit.edu	37	chr20	43255222	43255222	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aactcataggcgatccttttGatagcctcccggcagcccct	8	15	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr20:43255222G>A	uc002xmj.2	-	4	365	c.237C>T	c.(235-237)ATC>ATT	p.I79I	ADA_uc010ggt.2_RNA	NM_000022	NP_000013	P00813	ADA_HUMAN	adenosine deaminase	79					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			pancreas(2)|ovary(1)	3		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	CGATCCTTTTGATAGCCTCCC	0.567									Adenosine_Deaminase_Deficiency				0	0	0	0.059317	0	29	79										A	43255222	G	A	43255222	2	1	24	1	0	0	0	0	0	0	0	1	230	1280	45	1		1	ADA	20	43255222	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	9012532	43255222	19770298	187	6901										
ZNF335	63925	broad.mit.edu	37	chr20	44589147	44589147	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	attttgaaggtgtagcgcttCttaaaggactttccacactg	9	8	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr20:44589147C>G	uc002xqw.2	-	13	1923	c.1800G>C	c.(1798-1800)AAG>AAC	p.K600N	ZNF335_uc010zxk.1_Missense_Mutation_p.K445N	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	600	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TGTAGCGCTTCTTAAAGGACT	0.622													0	0	0	0.048971	0	47	113										G	44589147	C	G	44589147	3	3	24	1	0	0	0	0	1	0	0	0	17849	912	32	1	2292	1	ZNF335	20	44589147	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	1333925	44589147	18436373	188	6902										
ZNF295	49854	broad.mit.edu	37	chr21	43413917	43413917	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgcacagcagcaaggctgctCttctcaacaaatagagagga	10	10	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr21:43413917C>T	uc002zab.3	-	3	502	c.288G>A	c.(286-288)AAG>AAA	p.K96K	ZNF295_uc002yzz.3_Silent_p.K96K|ZNF295_uc002yzy.3_Silent_p.K96K|ZNF295_uc002zaa.3_Silent_p.K96K|ZNF295_uc010gov.1_Silent_p.K96K|ZNF295_uc002zac.2_Silent_p.K96K	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	96	Mediates homodimerization.|BTB.				negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CAAGGCTGCTCTTCTCAACAA	0.398													0	0	0	0.028581	0	16	38										T	43413917	C	T	43413917	2	4	24	1	0	0	0	0	0	0	0	1	17824	912	32	1		1	ZNF295	21	43413917	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		43413917	4715978	189	6903										
RIMBP3	85376	broad.mit.edu	37	chr22	20457929	20457929	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	atctgcatacacagcataacCggtgacctggactccattgg	9	12	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr22:20457929C>T	uc002zsd.3	-	1	3858	c.3373G>A	c.(3373-3375)GGT>AGT	p.G1125S		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			ACAGCATAACCGGTGACCTGG	0.592													0	0	0	0.02938	0	4	28										T	20457929	C	T	20457929	3	4	24	1	0	0	0	0	1	0	0	0	13364	652	23	2	1550	2	RIMBP3	22	20457929	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		20457929	30846637	190	6904										
MED15	51586	broad.mit.edu	37	chr22	20939289	20939289	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	cagccatgaccgccattcacGgcccacccatcacgtatgtc	7	18	2	1	rs147995933		TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr22:20939289G>A	uc002zsp.2	+	15	2031	c.1951G>A	c.(1951-1953)GGC>AGC	p.G651S	MED15_uc002zsq.2_Missense_Mutation_p.G611S|MED15_uc010gso.2_Missense_Mutation_p.G594S|MED15_uc002zsr.2_Missense_Mutation_p.G585S|MED15_uc011ahs.1_Missense_Mutation_p.G585S|MED15_uc002zss.2_Missense_Mutation_p.G530S|MED15_uc011ahu.1_Missense_Mutation_p.G361S|MED15_uc002zst.2_Missense_Mutation_p.G267S|MED15_uc002zsu.2_Missense_Mutation_p.G256S	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	651					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			CGCCATTCACGGCCCACCCAT	0.657													0	0	0	0.036044	0	20	106										A	20939289	G	A	20939289	3	1	24	1	0	0	0	0	1	0	0	0	9433	1116	39	2	2009	2	MED15	22	20939289	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	481360	20939289	30365277	191	6905										
CRYBB1	1414	broad.mit.edu	37	chr22	27008146	27008146	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tggaagttttccagttcgaaGaccaccagctgcaggagaga	12	9	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr22:27008146G>T	uc003acy.1	-	3	259	c.189C>A	c.(187-189)GTC>GTA	p.V63V		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	63	Beta/gamma crystallin 'Greek key' 1.				visual perception		structural constituent of eye lens			ovary(1)	1						CCAGTTCGAAGACCACCAGCT	0.532													1	0	7.87624e-14	0.076483	8.35567e-14	23	93										T	27008146	G	T	27008146	2	4	24	1	0	0	0	0	0	0	0	1	3910	929	33	3		3	CRYBB1	22	27008146	Silent	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	6068857	27008146	24296420	192	6906										
MICALL1	85377	broad.mit.edu	37	chr22	38327931	38327931	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggacacggctttccactcatCaaacgcaaggtaccagctgg	10	13	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr22:38327931C>T	uc003aui.2	+	10	2091	c.2007C>T	c.(2005-2007)ATC>ATT	p.I669I		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	669						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					TTCCACTCATCAAACGCAAGG	0.642													0	0	0	0.074837	0	31	65										T	38327931	C	T	38327931	2	4	24	1	0	0	0	0	0	0	0	1	9573	816	29	1		1	MICALL1	22	38327931	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	11319785	38327931	12976635	193	6907										
MICALL1	85377	broad.mit.edu	37	chr22	38328839	38328839	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gacatgctggtggactggttCaagctcatccacgagaagca	12	10	2	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr22:38328839C>T	uc003aui.2	+	12	2262	c.2178C>T	c.(2176-2178)TTC>TTT	p.F726F		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	726						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					TGGACTGGTTCAAGCTCATCC	0.617													0	0	0	0.09319	0	11	59										T	38328839	C	T	38328839	2	4	24	1	0	0	0	0	0	0	0	1	9573	825	29	1		1	MICALL1	22	38328839	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	908	38328839	12975727	194	6908										
GTSE1	51512	broad.mit.edu	37	chr22	46722532	46722532	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggagacgttcctctgagcccCgcaagaactctgcaatgagg	12	12	2	4			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chr22:46722532C>T	uc011aqy.1	+	9	1917	c.1705C>T	c.(1705-1707)CGC>TGC	p.R569C	GTSE1_uc011aqz.1_Missense_Mutation_p.R416C|GTSE1_uc003bhl.1_Missense_Mutation_p.R194C|GTSE1_uc003bhm.1_Missense_Mutation_p.R194C|GTSE1_uc003bhn.2_5'Flank	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	550					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CTCTGAGCCCCGCAAGAACTC	0.562													0	0	0	0.049695	0	11	62										T	46722532	C	T	46722532	3	4	24	1	0	0	0	0	1	0	0	0	6885	652	23	2	1735	2	GTSE1	22	46722532	Missense_Mutation	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	8393693	46722532	4582034	195	6909										
RBM10	8241	broad.mit.edu	37	chrX	47041369	47041369	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	gctgttcccgacgtctctacCtaccagtacgatgagacctc	8	15	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chrX:47041369C>G	uc004dhf.2	+	16	2092	c.1713C>G	c.(1711-1713)ACC>ACG	p.T571T	RBM10_uc004dhg.2_Silent_p.T493T|RBM10_uc004dhh.2_Silent_p.T570T|RBM10_uc010nhq.2_Silent_p.T494T|RBM10_uc004dhi.2_Silent_p.T636T	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	571	Tyr-rich.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						ACGTCTCTACCTACCAGTACG	0.582													0	0	0	0.034045	0	30	21										G	47041369	C	G	47041369	2	3	24	1	0	0	0	0	0	0	0	1	13111	668	24	4		4	RBM10	23	47041369	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08		47041369	108229191	196	6910										
RBM10	8241	broad.mit.edu	37	chrX	47045533	47045533	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tccccgagccgccagagcccAagaggaggaagtacggcggc	15	14	0	2			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chrX:47045533A>T	uc004dhf.2	+	22	2879	c.2500A>T	c.(2500-2502)AAG>TAG	p.K834*	RBM10_uc004dhg.2_Nonsense_Mutation_p.K756*|RBM10_uc004dhh.2_Nonsense_Mutation_p.K833*|RBM10_uc010nhq.2_Nonsense_Mutation_p.K757*|RBM10_uc004dhi.2_Nonsense_Mutation_p.K899*	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	834					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						GCCAGAGCCCAAGAGGAGGAA	0.607													0	0	0	0.099896	0	22	18										T	47045533	A	T	47045533	4	4	24	1	0	0	0	0	0	1	0	0	13111	131	5	5	2582	5	RBM10	23	47045533	Nonsense_Mutation	SNP	A	TCGA-C4-A0F1-01A-11D-A10S-08	4164	47045533	108225027	197	6911										
FAM123B	139285	broad.mit.edu	37	chrX	63413139	63413139	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	ggctgcagctcccttggcctGagcagcttcatccttttggg	12	13	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chrX:63413139G>A	uc004dvo.2	-	2	301	c.28C>T	c.(28-30)CAG>TAG	p.Q10*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	10					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCCTTGGCCTGAGCAGCTTCA	0.527													0	0	0	0.104719	0	42	36										A	63413139	G	A	63413139	4	1	24	1	0	0	0	0	0	1	0	0	5423	1299	45	1	3383	1	FAM123B	23	63413139	Nonsense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	16367606	63413139	91857421	198	6912										
ZMYM3	9203	broad.mit.edu	37	chrX	70470410	70470410	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	tgccccttctgcagtggtgtCcggcaatgtgcacaagtcat	11	12	2	0			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chrX:70470410C>T	uc004dzh.1	-	5	1032	c.945G>A	c.(943-945)CGG>CGA	p.R315R	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.R315R|ZMYM3_uc004dzj.1_Silent_p.R315R|ZMYM3_uc011mpu.1_Silent_p.R46R|ZMYM3_uc004dzk.3_Silent_p.R315R|ZMYM3_uc004dzl.3_Silent_p.R315R|ZMYM3_uc004dzm.3_Silent_p.R315R	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	315					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					GCAGTGGTGTCCGGCAATGTG	0.622													0	0	0	0.028581	0	14	8										T	70470410	C	T	70470410	2	4	24	1	0	0	0	0	0	0	0	1	17698	842	30	1		1	ZMYM3	23	70470410	Silent	SNP	C	TCGA-C4-A0F1-01A-11D-A10S-08	7057271	70470410	84800150	199	6913										
MAGEE1	57692	broad.mit.edu	37	chrX	75650837	75650837	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.402010050251256	80	2.45877325158608e-24	3.41556291390728	4.65758579169175	2.94445078785111	0.00372299320670154	0.0146663368748849	57	aggcctggcaacaactttttGatgcaggtcctaagcttcat	9	10	1	1			TCGA-C4-A0F1-01A-11D-A10S-08	TCGA-C4-A0F1-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9377460a-8497-41b8-b2c2-5f50cfeda1fe	6f297c27-b481-4101-833d-bd43bd80ba29	g.chrX:75650837G>C	uc004ecm.1	+	1	2721	c.2514G>C	c.(2512-2514)TTG>TTC	p.L838F		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	838	Interaction with DTNA (By similarity).|MAGE 2.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						ACAACTTTTTGATGCAGGTCC	0.502													0	0	0	0.080935	0	11	14										C	75650837	G	C	75650837	3	2	24	1	0	0	0	0	1	0	0	0	9185	1281	45	1	2516	1	MAGEE1	23	75650837	Missense_Mutation	SNP	G	TCGA-C4-A0F1-01A-11D-A10S-08	5180427	75650837	79619723	200	6914										
EIF2C1	26523	broad.mit.edu	37	chr1	36379798	36379798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgctcagctctgccgtttttCaacagccagtgatattcctg	8	12	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:36379798C>G	uc001bzl.2	+	14	1969	c.1756C>G	c.(1756-1758)CAA>GAA	p.Q586E	EIF2C1_uc001bzk.2_Missense_Mutation_p.Q511E|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	586	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGCCGTTTTTCAACAGCCAGT	0.517													0	0	0	0.139131	0	122	33										G	36379798	C	G	36379798	3	3	25	1	0	0	0	0	1	0	0	0	5005	827	29	1	1810	1	EIF2C1	1	36379798	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		36379798	212870823	1	6915										
KIAA0467	23334	broad.mit.edu	37	chr1	43895747	43895747	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tccaatccccactacttcttCtattgccctccatccagcag	3	18	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:43895747C>T	uc001cjk.1	+	15	2139	c.1677C>T	c.(1675-1677)TTC>TTT	p.F559F		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1458						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACTACTTCTTCTATTGCCCTC	0.537													0	0	0	0.139131	0	145	52										T	43895747	C	T	43895747	2	4	25	1	0	0	0	0	0	0	0	1	8178	912	32	1		1	KIAA0467	1	43895747	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	7515949	43895747	205354874	2	6916										
CTH	1491	broad.mit.edu	37	chr1	70897873	70897873	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aaaacggaatggcagttgccCagttcctggaatctaatcct	9	10	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:70897873C>G	uc001dfd.2	+	8	976	c.832C>G	c.(832-834)CAG>GAG	p.Q278E	CTH_uc009wbl.1_RNA|CTH_uc001dfe.2_Missense_Mutation_p.Q234E|CTH_uc010oqq.1_Missense_Mutation_p.Q246E	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	278					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GGCAGTTGCCCAGTTCCTGGA	0.403													0	0	0	0.139131	0	67	23										G	70897873	C	G	70897873	3	3	25	1	0	0	0	0	1	0	0	0	4009	595	21	4	862	4	CTH	1	70897873	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	27002126	70897873	178352748	3	6917										
FPGT	8790	broad.mit.edu	37	chr1	74671227	74671227	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctttggagtctgtttcctgtCatgcttagatgtttggaatc	10	7	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:74671227C>A	uc001dgb.1	+	4	1533	c.1496C>A	c.(1495-1497)TCA>TAA	p.S499*	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Nonsense_Mutation_p.S124*|FPGT_uc010oqu.1_Nonsense_Mutation_p.S245*|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	499					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TGTTTCCTGTCATGCTTAGAT	0.378													1	0	5.2432e-18	0.139131	5.66114e-18	49	57										A	74671227	C	A	74671227	4	1	25	1	0	0	0	0	0	1	0	0	6037	838	29	3	1510	3	FPGT	1	74671227	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	3773354	74671227	174579394	4	6918										
SLC35A3	23443	broad.mit.edu	37	chr1	100459152	100459152	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtttccctgggaattttggtCtttcagactaccagtttggt	10	8	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:100459152C>G	uc001dsp.1	+	2	239	c.42C>G	c.(40-42)GTC>GTG	p.V14V	SLC35A3_uc001dsq.1_Silent_p.V14V|SLC35A3_uc009wdy.1_Silent_p.V14V|SLC35A3_uc001dsr.1_Silent_p.V56V|SLC35A3_uc001dss.1_5'Flank	NM_012243	NP_036375	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 member 3A	14	Helical; (Potential).				UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		GAATTTTGGTCTTTCAGACTA	0.358													0	0	0	0.009096	0	4	123										G	100459152	C	G	100459152	2	3	25	1	0	0	0	0	0	0	0	1	14572	900	32	1		1	SLC35A3	1	100459152	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	25787925	100459152	148791469	5	6919										
MAN1A2	10905	broad.mit.edu	37	chr1	117944812	117944812	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccttcttttctcacagggaaGaggaagaacgtctgagaaat	10	8	3	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:117944812G>C	uc001ehd.1	+	2	1028	c.307G>C	c.(307-309)GAG>CAG	p.E103Q	MAN1A2_uc009whg.1_Intron	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	103	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TCACAGGGAAGAGGAAGAACG	0.363													0	0	0	0.069456	0	32	26										C	117944812	G	C	117944812	3	2	25	1	0	0	0	0	1	0	0	0	9211	943	33	1	313	1	MAN1A2	1	117944812	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	17485660	117944812	131305809	6	6920										
HRNR	388697	broad.mit.edu	37	chr1	152188199	152188199	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggaagaccaccctgagccaGacccatatgggccgtagctg	12	13	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:152188199G>C	uc001ezt.1	-	3	5982	c.5906C>G	c.(5905-5907)TCT>TGT	p.S1969C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1969	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGAGCCAGACCCATATGG	0.617													0	0	0	0.074837	0	39	859										C	152188199	G	C	152188199	3	2	25	1	0	0	0	0	1	0	0	0	7359	942	33	1	2650	1	HRNR	1	152188199	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	34243387	152188199	97062422	7	6921										
OR6Y1	391112	broad.mit.edu	37	chr1	158516978	158516978	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgcaatgtatggtctttctGagggctgcctttacttcatg	10	9	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:158516978G>A	uc010pil.1	-	1	918	c.918C>T	c.(916-918)CTC>CTT	p.L306L		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGGTCTTTCTGAGGGCTGCCT	0.438													0	0	0	0.099896	0	28	83										A	158516978	G	A	158516978	2	1	25	1	0	0	0	0	0	0	0	1	11213	1277	45	1		1	OR6Y1	1	158516978	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	6328779	158516978	90733643	8	6922										
DARS2	55157	broad.mit.edu	37	chr1	173795914	173795914	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcaccttgtgtggatggattCagtaccgaaggtaaattgag	12	6	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:173795914C>A	uc001gjh.1	+	2	627	c.217C>A	c.(217-219)CAG>AAG	p.Q73K	CENPL_uc009wwg.2_5'Flank|CENPL_uc001gje.3_5'Flank|CENPL_uc001gjg.3_5'Flank|CENPL_uc001gjf.3_5'Flank	NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	73					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	TGGATGGATTCAGTACCGAAG	0.423													1	0	6.27289e-28	0.139131	6.87251e-28	53	43										A	173795914	C	A	173795914	3	1	25	1	0	0	0	0	1	0	0	0	4242	827	29	3	223	3	DARS2	1	173795914	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	15278936	173795914	75454707	9	6923										
FAM5B	57795	broad.mit.edu	37	chr1	177245564	177245564	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctcacaaccggcagtttgaaGagtcaggtgagcagccagaa	12	10	2	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:177245564G>A	uc001glf.2	+	6	1318	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	FAM5B_uc010pna.1_Missense_Mutation_p.E86K|FAM5B_uc001glg.2_Missense_Mutation_p.E231K	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	336						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GCAGTTTGAAGAGTCAGGTGA	0.388													0	0	0	0.074837	0	36	37										A	177245564	G	A	177245564	3	1	25	1	0	0	0	0	1	0	0	0	5593	943	33	1	1024	1	FAM5B	1	177245564	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	3449650	177245564	72005057	10	6924										
CRB1	23418	broad.mit.edu	37	chr1	197390534	197390534	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caatggctcttctacttttcCgaagcaacagggatgtgttt	9	9	2	0	rs114342808	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:197390534C>T	uc001gtz.2	+	6	1711	c.1576C>T	c.(1576-1578)CGA>TGA	p.R526*	CRB1_uc010poz.1_Nonsense_Mutation_p.R457*|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Nonsense_Mutation_p.R414*|CRB1_uc010ppb.1_Nonsense_Mutation_p.R526*|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Nonsense_Mutation_p.R7*|CRB1_uc001gub.1_Nonsense_Mutation_p.R175*	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	526	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TCTACTTTTCCGAAGCAACAG	0.453													0	0	0	0.139131	0	55	52										T	197390534	C	T	197390534	4	4	25	1	0	0	0	0	0	1	0	0	3848	644	23	2	1598	2	CRB1	1	197390534	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	20144970	197390534	51860087	11	6925										
KLHDC8A	55220	broad.mit.edu	37	chr1	205306715	205306715	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cgtctccaggacagtgggttGattccctgaaagtgtcaagg	13	9	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:205306715G>C	uc001hcf.1	-	6	1433	c.865C>G	c.(865-867)CAA>GAA	p.Q289E	KLHDC8A_uc010prg.1_Missense_Mutation_p.Q176E|KLHDC8A_uc001hcg.1_Missense_Mutation_p.Q289E	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	289	Kelch 7.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACAGTGGGTTGATTCCCTGAA	0.587													0	0	0	0.125774	0	30	94										C	205306715	G	C	205306715	3	2	25	1	0	0	0	0	1	0	0	0	8362	1299	45	1	191	1	KLHDC8A	1	205306715	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	7916181	205306715	43943906	12	6926										
SNTG2	54221	broad.mit.edu	37	chr2	1241711	1241711	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggagtcagctctgggatcctCcggttttacacagcccagga	12	12	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:1241711C>T	uc002qwq.2	+	10	899	c.771C>T	c.(769-771)CTC>CTT	p.L257L	SNTG2_uc010ewi.2_Silent_p.L130L	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	257					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CTGGGATCCTCCGGTTTTACA	0.642													0	0	0	0.02938	0	6	8										T	1241711	C	T	1241711	2	4	25	1	0	0	0	0	0	0	0	1	14875	842	30	1		1	SNTG2	2	1241711	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		1241711	241957662	13	6927										
TPO	7173	broad.mit.edu	37	chr2	1520688	1520688	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccctcgggtgacttggatctCcatgtcgctggctgctctgc	12	14	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:1520688C>T	uc002qww.2	+	15	2643	c.2552C>T	c.(2551-2553)TCC>TTC	p.S851F	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.S794F|TPO_uc002qwr.2_Missense_Mutation_p.S851F|TPO_uc002qwx.2_Missense_Mutation_p.S794F|TPO_uc010yio.1_Missense_Mutation_p.S678F|TPO_uc010yip.1_Missense_Mutation_p.S807F|TPO_uc002qwy.1_Missense_Mutation_p.S147F|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	851	Helical; (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACTTGGATCTCCATGTCGCTG	0.572													0	0	0	0.074837	0	35	73										T	1520688	C	T	1520688	3	4	25	1	0	0	0	0	1	0	0	0	16407	855	30	1	2606	1	TPO	2	1520688	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	278977	1520688	241678685	14	6928										
TRIM54	57159	broad.mit.edu	37	chr2	27505677	27505677	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctggagaagcagctcatctgCcccatctgcctggagatgtt	11	12	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:27505677C>T	uc002rjo.2	+	1	78	c.78C>T	c.(76-78)TGC>TGT	p.C26C	TRIM54_uc002rjn.2_Silent_p.C26C	NM_187841	NP_912730	Q9BYV2	TRI54_HUMAN	ring finger protein 30 isoform 2	26	RING-type.				cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTCATCTGCCCCATCTGCC	0.587													0	0	0	0.139131	0	72	360										T	27505677	C	T	27505677	2	4	25	1	0	0	0	0	0	0	0	1	16525	747	26	2		2	TRIM54	2	27505677	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	25984989	27505677	215693696	15	6929										
PSME4	23198	broad.mit.edu	37	chr2	54159084	54159084	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	catagccaagaggacaggctGaataatgcattgtacaaagt	10	7	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:54159084G>A	uc002rxp.2	-	10	1260	c.1204C>T	c.(1204-1206)CAG>TAG	p.Q402*	PSME4_uc010yop.1_Nonsense_Mutation_p.Q288*|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	402					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGGACAGGCTGAATAATGCAT	0.453													0	0	0	0.117977	0	44	57										A	54159084	G	A	54159084	4	1	25	1	0	0	0	0	0	1	0	0	12709	1299	45	1	4475	1	PSME4	2	54159084	Nonsense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	26653407	54159084	189040289	16	6930										
REG3G	130120	broad.mit.edu	37	chr2	79254983	79254983	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggagtagcactgatgtgatGaattactttgcatgggagaa	13	4	0	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:79254983G>A	uc002snw.2	+	5	469	c.384G>A	c.(382-384)ATG>ATA	p.M128I	REG3G_uc002snx.2_Missense_Mutation_p.M128I|REG3G_uc010ffu.2_Missense_Mutation_p.M82I	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	128	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						CTGATGTGATGAATTACTTTG	0.502													0	0	0	0.117977	0	45	174										A	79254983	G	A	79254983	3	1	25	1	0	0	0	0	1	0	0	0	13213	1290	45	1	398	1	REG3G	2	79254983	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	25095899	79254983	163944390	17	6931										
FER1L5	90342	broad.mit.edu	37	chr2	97361264	97361264	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agatcctggcctggggccttCggaacatgaagaaggcgagc	15	10	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:97361264C>T	uc010fia.2	+	34	3841	c.3841C>T	c.(3841-3843)CGG>TGG	p.R1281W	FER1L5_uc002sws.3_5'UTR|FER1L5_uc010fib.1_RNA|FER1L5_uc002swt.3_5'UTR|FER1L5_uc010yus.1_5'UTR	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1281						integral to membrane				ovary(1)	1						CTGGGGCCTTCGGAACATGAA	0.602													0	0	0	0.047766	0	8	8										T	97361264	C	T	97361264	3	4	25	1	0	0	0	0	1	0	0	0	5814	875	31	1	3975	1	FER1L5	2	97361264	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	18106281	97361264	145838109	18	6932										
GPR45	11250	broad.mit.edu	37	chr2	105858505	105858505	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcatcgtgtaccagaggccgGctatgcgctcggccatcaac	11	14	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:105858505G>A	uc002tco.1	+	1	306	c.190G>A	c.(190-192)GCT>ACT	p.A64T		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	64	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CCAGAGGCCGGCTATGCGCTC	0.617													0	0	0	0.139131	0	110	46										A	105858505	G	A	105858505	3	1	25	1	0	0	0	0	1	0	0	0	6696	1203	42	2	192	2	GPR45	2	105858505	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	8497241	105858505	137340868	19	6933										
ST6GAL2	84620	broad.mit.edu	37	chr2	107460193	107460193	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	accggctgggtgggcgcgggGcagcgcctggcgtgcgtcca	20	13	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:107460193G>C	uc002tdq.2	-	2	360	c.241C>G	c.(241-243)CCC>GCC	p.P81A	ST6GAL2_uc002tdr.2_Missense_Mutation_p.P81A|ST6GAL2_uc002tds.3_Missense_Mutation_p.P81A	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	81	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TGGGCGCGGGGCAGCGCCTGG	0.657													0	0	0	0.125774	0	27	72										C	107460193	G	C	107460193	3	2	25	1	0	0	0	0	1	0	0	0	15221	1203	42	4	1455	4	ST6GAL2	2	107460193	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1601688	107460193	135739180	20	6934										
HNMT	3176	broad.mit.edu	37	chr2	138771674	138771674	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aggttctttttaataatactCtgagtttcatagtgattgag	8	4	3	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:138771674C>G	uc002tvc.2	+	7	1001	c.853C>G	c.(853-855)CTG>GTG	p.L285V	HNMT_uc002tvf.2_Missense_Mutation_p.L285V	NM_006895	NP_008826	P50135	HNMT_HUMAN	histamine N-methyltransferase isoform 1	285					respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)	TAATAATACTCTGAGTTTCAT	0.343													0	0	0	0.049695	0	19	112										G	138771674	C	G	138771674	3	3	25	1	0	0	0	0	1	0	0	0	7255	912	32	1	1093	1	HNMT	2	138771674	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	31311481	138771674	104427699	21	6935										
LRP1B	53353	broad.mit.edu	37	chr2	141598563	141598563	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggttttcaaagagccatctaGccttgccacattaatttgcg	8	10	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:141598563G>A	uc002tvj.1	-	30	6010	c.5038C>T	c.(5038-5040)CTA>TTA	p.L1680L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1680	Extracellular (Potential).|LDL-receptor class B 15.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGCCATCTAGCCTTGCCACA	0.398										TSP Lung(27;0.18)			0	0	0	0.131918	0	48	62										A	141598563	G	A	141598563	2	1	25	1	0	0	0	0	0	0	0	1	8955	962	34	2		2	LRP1B	2	141598563	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2826889	141598563	101600810	22	6936										
KCNH7	90134	broad.mit.edu	37	chr2	163302755	163302755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gctacaagaatagccacattCtcgtcttttctgttcttctc	5	12	5	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:163302755C>G	uc002uch.1	-	7	1539	c.1327G>C	c.(1327-1329)GAA>CAA	p.E443Q	KCNH7_uc002uci.2_Missense_Mutation_p.E436Q	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	443	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TAGCCACATTCTCGTCTTTTC	0.378													0	0	0	0.108266	0	28	39										G	163302755	C	G	163302755	3	3	25	1	0	0	0	0	1	0	0	0	8037	922	32	1	2369	1	KCNH7	2	163302755	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	21704192	163302755	79896618	23	6937										
NFE2L2	4780	broad.mit.edu	37	chr2	178095734	178095734	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caatttttctttttcatcttTcaaatgatctaaatcttgct	2	8	6	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:178095734T>G	uc002ulh.3	-	5	2152	c.1597A>C	c.(1597-1599)AAA>CAA	p.K533Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.K517Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.K510Q|NFE2L2_uc002uli.3_Missense_Mutation_p.K517Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	533	Leucine-zipper.				transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTTTCATCTTTCAAATGATCT	0.343			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.139131	0	101	103										G	178095734	T	G	178095734	3	3	25	1	0	0	0	0	1	0	0	0	10368	1792	62	5	224	5	NFE2L2	2	178095734	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	14792979	178095734	65103639	24	6938										
TTN	7273	broad.mit.edu	37	chr2	179482509	179482509	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttttttgatgggcttaccaaTtggatcagcaactttgacga	9	7	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:179482509T>C	uc010zfg.1	-	202	40089	c.39865A>G	c.(39865-39867)ATT>GTT	p.I13289V	TTN_uc010zfh.1_Missense_Mutation_p.I6984V|TTN_uc010zfi.1_Missense_Mutation_p.I6917V|TTN_uc010zfj.1_Missense_Mutation_p.I6792V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14216							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTACCAATTGGATCAGCA	0.378													0	0	0	0.062417	0	17	68										C	179482509	T	C	179482509	3	2	25	1	0	0	0	0	1	0	0	0	16732	1493	52	5	60564	5	TTN	2	179482509	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	1386775	179482509	63716864	25	6939										
CASP8	841	broad.mit.edu	37	chr2	202141587	202141587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccaaatgaaaagcaaacctcGgggatactgtctgatcatca	8	10	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:202141587G>A	uc002uxr.1	+	8	907	c.698G>A	c.(697-699)CGG>CAG	p.R233Q	CASP8_uc002uxo.1_Silent_p.S211S|CASP8_uc002uxp.1_Missense_Mutation_p.R250Q|CASP8_uc002uxq.1_Missense_Mutation_p.R218Q|CASP8_uc002uxt.1_Missense_Mutation_p.R292Q|CASP8_uc002uxu.1_RNA|CASP8_uc002uxv.1_Missense_Mutation_p.R218Q|CASP8_uc002uxw.1_Missense_Mutation_p.R218Q|CASP8_uc002uxy.1_Missense_Mutation_p.R233Q|CASP8_uc002uxx.1_Missense_Mutation_p.R218Q|CASP8_uc010ftf.2_Intron|CASP8_uc010fte.1_Silent_p.S93S	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	233					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AGCAAACCTCGGGGATACTGT	0.428										HNSCC(4;0.00038)			0	0	0	0.134883	0	26	21										A	202141587	G	A	202141587	3	1	25	1	0	0	0	0	1	0	0	0	2677	1116	39	2	1001	2	CASP8	2	202141587	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	22659078	202141587	41057786	26	6940										
PLCD4	84812	broad.mit.edu	37	chr2	219501002	219501002	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggggcagacactatgtttccGggtgctggtgcctgaacttg	15	9	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:219501002G>A	uc002vij.1	+	15	2264	c.2069G>A	c.(2068-2070)CGG>CAG	p.R690Q		NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	690	C2.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CTATGTTTCCGGGTGCTGGTG	0.448													0	0	0	0.139131	0	168	183										A	219501002	G	A	219501002	3	1	25	1	0	0	0	0	1	0	0	0	12033	1116	39	2	2123	2	PLCD4	2	219501002	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	17359415	219501002	23698371	27	6941										
CRYBA2	1412	broad.mit.edu	37	chr2	219857870	219857884	+	In_Frame_Del	DEL	GCCGGGCCCGGCGCG	GCCGGGCCCGGCGCG	-													0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agagcgtgaggctggcgggcGccgggcccggcgcgggggcg					rs141631259	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:219857870_219857884delGCCGGGCCCGGCGCG	uc002vjj.1	-	2	50_64	c.15_29delCGCGCCGGGCCCGGC	c.(13-30)CCCGCGCCGGGCCCGGCG>CCG	p.APGPA6del	CRYBA2_uc002vjk.1_In_Frame_Del_p.APGPA6del	NM_057094	NP_476435	P53672	CRBA2_HUMAN	crystallin, beta A2	6_10	N-terminal arm.						structural constituent of eye lens				0		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTggcgggcgccgggcccggcgcgggggcgcTGC	0.581																		6	11	---	---								-	219857884	GCCGGGCCCGGCGCG	-	219857870	7	5	25	1	0	1	0	1	0	0	0	0	3908	1087	38	0	580	0	CRYBA2	2	219857870	In_Frame_Del	DEL	GCCGGGCCCGGCGCG	TCGA-C4-A0F6-01A-11D-A10S-08	356868	219857870	23341503	28	6942										
KIF1A	547	broad.mit.edu	37	chr2	241702670	241702670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agtccacaggctcagctggcGtctccgcacaaggcgtgcgc	13	15	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:241702670G>A	uc002vzy.2	-	20	1981	c.1835C>T	c.(1834-1836)ACG>ATG	p.T612M	KIF1A_uc010fzk.2_Missense_Mutation_p.T621M|KIF1A_uc002vzz.1_Missense_Mutation_p.T621M	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	612					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTCAGCTGGCGTCTCCGCACA	0.642													0	0	0	0.021553	0	6	11										A	241702670	G	A	241702670	3	1	25	1	0	0	0	0	1	0	0	0	8283	1145	40	2	3349	2	KIF1A	2	241702670	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	21844800	241702670	1496703	29	6943										
GRM7	2917	broad.mit.edu	37	chr3	6903515	6903515	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	accgccggttttcgtcaagcCggagaaagtagttggagtga	14	8	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:6903515C>T	uc003bqm.2	+	1	714	c.440C>T	c.(439-441)CCG>CTG	p.P147L	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.P147L|GRM7_uc003bql.2_Missense_Mutation_p.P147L	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	147	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TTCGTCAAGCCGGAGAAAGTA	0.597													0	0	0	0.0918	0	23	70										T	6903515	C	T	6903515	3	4	25	1	0	0	0	0	1	0	0	0	6802	652	23	2	442	2	GRM7	3	6903515	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		6903515	191118915	30	6944										
VILL	50853	broad.mit.edu	37	chr3	38039653	38039653	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgacccaggacctgctgcaGgaggaggtgaggaaggcctg	17	10	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:38039653G>A	uc003chj.2	+	8	1123	c.837G>A	c.(835-837)CAG>CAA	p.Q279Q	VILL_uc003chk.1_Silent_p.Q279Q|VILL_uc003chl.2_Silent_p.Q279Q|VILL_uc010hgu.2_Silent_p.Q109Q	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	279	Gelsolin-like 3.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		ACCTGCTGCAGGAGGAGGTGA	0.642													0	0	0	0.069234	0	11	35										A	38039653	G	A	38039653	2	1	25	1	0	0	0	0	0	0	0	1	17162	991	35	2		2	VILL	3	38039653	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	31136138	38039653	159982777	31	6945										
SLC6A20	54716	broad.mit.edu	37	chr3	45811793	45811793	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agatgcgaggtagcccttcaCctgctccaggttgctggctg	13	12	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:45811793C>T	uc011bai.1	-	7	1130	c.1006G>A	c.(1006-1008)GTG>ATG	p.V336M	SLC6A20_uc003cow.2_Translation_Start_Site|SLC6A20_uc011baj.1_Missense_Mutation_p.V299M	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	336	Extracellular (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TAGCCCTTCACCTGCTCCAGG	0.517													0	0	0	0.11911	0	15	61										T	45811793	C	T	45811793	3	4	25	1	0	0	0	0	1	0	0	0	14684	507	18	2	792	2	SLC6A20	3	45811793	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	7772140	45811793	152210637	32	6946										
SMARCC1	6599	broad.mit.edu	37	chr3	47752241	47752241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	attttcatccacctcataatCctcctcattcatccattcat	0	15	5	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:47752241C>T	uc003crq.2	-	9	968	c.850G>A	c.(850-852)GAT>AAT	p.D284N	SMARCC1_uc011bbd.1_Missense_Mutation_p.D175N	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	284					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		ACCTCATAATCCTCCTCATTC	0.343													0	0	0	0.064281	0	33	89										T	47752241	C	T	47752241	3	4	25	1	0	0	0	0	1	0	0	0	14775	855	30	1	2547	1	SMARCC1	3	47752241	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	1940448	47752241	150270189	33	6947										
RNF123	63891	broad.mit.edu	37	chr3	49757948	49757948	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	accctcccctacctaggagaGagcaagccacatcagtgctc	8	16	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:49757948G>C	uc003cxh.2	+	36	3591	c.3505G>C	c.(3505-3507)GAG>CAG	p.E1169Q	RNF123_uc003cxi.2_RNA|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1169						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		ACCTAGGAGAGAGCAAGCCAC	0.577													0	0	0	0.11911	0	14	56										C	49757948	G	C	49757948	3	2	25	1	0	0	0	0	1	0	0	0	13433	943	33	1	3643	1	RNF123	3	49757948	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2005707	49757948	148264482	34	6948										
CACNA1D	776	broad.mit.edu	37	chr3	53766966	53766966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atccctgaagggagcgctttCttcattcttagcaagaccaa	8	11	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:53766966C>G	uc003dgv.3	+	19	2761	c.2598C>G	c.(2596-2598)TTC>TTG	p.F866L	CACNA1D_uc003dgu.3_Missense_Mutation_p.F886L|CACNA1D_uc003dgy.3_Missense_Mutation_p.F866L|CACNA1D_uc003dgw.3_Missense_Mutation_p.F533L|CACNA1D_uc003dgx.1_Missense_Mutation_p.F14L	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	866	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGAGCGCTTTCTTCATTCTTA	0.527													0	0	0	0.080422	0	38	37										G	53766966	C	G	53766966	3	3	25	1	0	0	0	0	1	0	0	0	2541	912	32	1	2844	1	CACNA1D	3	53766966	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	4009018	53766966	144255464	35	6949										
SLC25A26	115286	broad.mit.edu	37	chr3	66293723	66293723	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaaacatatgttggctgcctCtgctggagaagtggtaagta	13	6	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:66293723C>T	uc011bfq.1	+	4	1015	c.287C>T	c.(286-288)TCT>TTT	p.S96F	SLC25A26_uc011bfs.1_Missense_Mutation_p.S8F|SLC25A26_uc011bft.1_RNA|SLC25A26_uc011bfr.1_Missense_Mutation_p.S96F|SLC25A26_uc003dmt.2_Missense_Mutation_p.S8F	NM_173471	NP_775742	Q70HW3	SAMC_HUMAN	solute carrier family 25, member 26 isoform a	96	Solcar 2.|Helical; Name=3; (Potential).					integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity			pancreas(1)	1		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)		TTGGCTGCCTCTGCTGGAGAA	0.313													0	0	0	0.09836	0	37	104										T	66293723	C	T	66293723	3	4	25	1	0	0	0	0	1	0	0	0	14489	913	32	1	99	1	SLC25A26	3	66293723	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	12526757	66293723	131728707	36	6950										
IFT122	55764	broad.mit.edu	37	chr3	129195257	129195257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gttcagacaagcaagtatctCttttcaccaaggatggagtg	10	8	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:129195257C>G	uc003emm.2	+	10	1122	c.916C>G	c.(916-918)CTT>GTT	p.L306V	IFT122_uc003eml.2_Missense_Mutation_p.L357V|IFT122_uc003emn.2_Missense_Mutation_p.L247V|IFT122_uc003emo.2_Missense_Mutation_p.L195V|IFT122_uc003emp.2_Missense_Mutation_p.L156V|IFT122_uc010htc.2_Missense_Mutation_p.L298V|IFT122_uc011bky.1_Missense_Mutation_p.L97V|IFT122_uc003emq.2_Missense_Mutation_p.L146V|IFT122_uc003emr.2_Missense_Mutation_p.L97V|IFT122_uc011bla.1_Missense_Mutation_p.L97V|IFT122_uc011bkx.1_Missense_Mutation_p.L146V|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	306	WD 5.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						GCAAGTATCTCTTTTCACCAA	0.507													0	0	0	0.139131	0	72	71										G	129195257	C	G	129195257	3	3	25	1	0	0	0	0	1	0	0	0	7555	913	32	1	1111	1	IFT122	3	129195257	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	62901534	129195257	68827173	37	6951										
IGSF10	285313	broad.mit.edu	37	chr3	151163672	151163672	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagtgggtgtagtgaagccaGaactctggtctggagagatg	16	6	2	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:151163672G>C	uc011bod.1	-	4	4097	c.4097C>G	c.(4096-4098)TCT>TGT	p.S1366C		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1366					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGAAGCCAGAACTCTGGTC	0.478													0	0	0	0.139131	0	62	221										C	151163672	G	C	151163672	3	2	25	1	0	0	0	0	1	0	0	0	7597	942	33	1	3834	1	IGSF10	3	151163672	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	21968415	151163672	46858758	38	6952										
NMD3	51068	broad.mit.edu	37	chr3	160942825	160942825	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aggtattccgaaacaagtctCgatttcgttctgcaaacaat	7	9	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:160942825C>A	uc003feb.1	+	3	271	c.152C>A	c.(151-153)TCG>TAG	p.S51*	NMD3_uc003fec.2_Nonsense_Mutation_p.S51*|NMD3_uc003fed.1_Nonsense_Mutation_p.S51*	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	51					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			AAACAAGTCTCGATTTCGTTC	0.413													1	0	7.50695e-29	0.139131	8.25488e-29	55	128										A	160942825	C	A	160942825	4	1	25	1	0	0	0	0	0	1	0	0	10488	893	31	3	158	3	NMD3	3	160942825	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	9779153	160942825	37079605	39	6953										
PPP1R2	5504	broad.mit.edu	37	chr3	195245954	195245954	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccttcattgtagtgaagcttCcttttcatttcaaattgtcg	6	9	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:195245954C>A	uc003fup.2	-	5	808	c.432G>T	c.(430-432)AGG>AGT	p.R144S		NM_006241	NP_006232	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory subunit 2	144					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			urinary_tract(1)	1	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		AGTGAAGCTTCCTTTTCATTT	0.284													1	0	1.22102e-19	0.139131	1.32797e-19	51	59										A	195245954	C	A	195245954	3	1	25	1	0	0	0	0	1	0	0	0	12370	854	30	3	193	3	PPP1R2	3	195245954	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	34303129	195245954	2776476	40	6954										
RPL35A	6165	broad.mit.edu	37	chr3	197678160	197678160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tctatttgggcaagagatgcGcttatgtatataaagcaaag	10	5	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:197678160G>A	uc003fyr.2	+	3	215	c.142G>A	c.(142-144)GCT>ACT	p.A48T	IQCG_uc003fyp.2_Intron|IQCG_uc003fyo.2_5'Flank|IQCG_uc003fyq.3_5'Flank|RPL35A_uc003fys.2_Missense_Mutation_p.A48T	NM_000996	NP_000987	P18077	RL35A_HUMAN	ribosomal protein L35a	48					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome|tRNA binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;1.04e-23)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.182)		CAAGAGATGCGCTTATGTATA	0.358													0	0	0	0.050027	0	29	85										A	197678160	G	A	197678160	3	1	25	1	0	0	0	0	1	0	0	0	13585	1087	38	2	148	2	RPL35A	3	197678160	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2432206	197678160	344270	41	6955										
PDE6B	5158	broad.mit.edu	37	chr4	656971	656971	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgggaagttcctgctctcgGaggaggttggtatactcacc	13	9	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:656971G>A	uc003gap.2	+	15	1968	c.1915G>A	c.(1915-1917)GAG>AAG	p.E639K	PDE6B_uc003gao.3_Missense_Mutation_p.E639K|PDE6B_uc011buy.1_Missense_Mutation_p.E360K|PDE6B_uc011buz.1_Missense_Mutation_p.E71K	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	639					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						CCTGCTCTCGGAGGAGGTTGG	0.622													0	0	0	0.074837	0	35	74										A	656971	G	A	656971	3	1	25	1	0	0	0	0	1	0	0	0	11646	1175	41	1	1973	1	PDE6B	4	656971	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		656971	190497305	42	6956										
TACC3	10460	broad.mit.edu	37	chr4	1733001	1733001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agcctgccttggagctgaaaGaggagagcttcagagacccc	13	11	1	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:1733001G>C	uc003gdo.2	+	6	1672	c.1564G>C	c.(1564-1566)GAG>CAG	p.E522Q	TACC3_uc010ibz.2_Missense_Mutation_p.E522Q|TACC3_uc003gdp.2_Missense_Mutation_p.E162Q|TACC3_uc010ica.2_5'UTR	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	522						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GGAGCTGAAAGAGGAGAGCTT	0.627													0	0	0	0.139131	0	58	115										C	1733001	G	C	1733001	3	2	25	1	0	0	0	0	1	0	0	0	15500	943	33	1	1582	1	TACC3	4	1733001	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1076030	1733001	189421275	43	6957										
LETM1	3954	broad.mit.edu	37	chr4	1843344	1843344	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cgaacagggcgcgaagagtgCcagccacgcacaggaaggca	15	12	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:1843344C>T	uc003gdv.2	-	3	621	c.324G>A	c.(322-324)TGG>TGA	p.W108*	LETM1_uc010icc.2_5'Flank|LETM1_uc011bvg.1_Nonsense_Mutation_p.W108*	NM_012318	NP_036450	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane	108					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			central_nervous_system(1)	1			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			GCGAAGAGTGCCAGCCACGCA	0.587													0	0	0	0.009096	0	4	122										T	1843344	C	T	1843344	4	4	25	1	0	0	0	0	0	1	0	0	8734	740	26	2	1943	2	LETM1	4	1843344	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	110343	1843344	189310932	44	6958										
LDB2	9079	broad.mit.edu	37	chr4	16900009	16900009	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgcagtctcttgttcatctCatagattcggtactctggct	8	11	4	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:16900009C>T	uc003goz.2	-	1	416	c.100G>A	c.(100-102)GAG>AAG	p.E34K	LDB2_uc003gpa.2_Missense_Mutation_p.E34K|LDB2_uc003gpb.2_Missense_Mutation_p.E34K|LDB2_uc011bxh.1_Missense_Mutation_p.E34K|LDB2_uc010iee.2_Missense_Mutation_p.E34K	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	34							LIM domain binding|transcription cofactor activity				0						TTGTTCATCTCATAGATTCGG	0.453													0	0	0	0.139131	0	68	76										T	16900009	C	T	16900009	3	4	25	1	0	0	0	0	1	0	0	0	8696	835	29	1	1162	1	LDB2	4	16900009	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	15056665	16900009	174254267	45	6959										
SOD3	6649	broad.mit.edu	37	chr4	24801248	24801248	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tctgactcggcggagtggatCcgagacatgtacgccaaggt	14	10	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:24801248C>T	uc003gqz.2	+	2	310	c.105C>T	c.(103-105)ATC>ATT	p.I35I	SOD3_uc003gqy.1_RNA	NM_003102	NP_003093	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular precursor	35					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding				0		Breast(46;0.0503)				CGGAGTGGATCCGAGACATGT	0.697													0	0	0	0.115264	0	3	9										T	24801248	C	T	24801248	2	4	25	1	0	0	0	0	0	0	0	1	14922	845	30	1		1	SOD3	4	24801248	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	7901239	24801248	166353028	46	6960										
PDGFRA	5156	broad.mit.edu	37	chr4	55139810	55139810	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggagggccgtgtgactttcGccaaagtggaggagaccatc	15	9	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:55139810G>A	uc003han.3	+	10	1802	c.1471G>A	c.(1471-1473)GCC>ACC	p.A491T	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.A385T|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	491	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGTGACTTTCGCCAAAGTGGA	0.532			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.0918	0	26	131										A	55139810	G	A	55139810	3	1	25	1	0	0	0	0	1	0	0	0	11661	1087	38	2	1505	2	PDGFRA	4	55139810	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	30338562	55139810	136014466	47	6961										
AASDH	132949	broad.mit.edu	37	chr4	57250456	57250456	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agccttatgcaccaattcctGaagagtcatttcactgaagt	7	10	2	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:57250456G>A	uc003hbn.2	-	2	163	c.10C>T	c.(10-12)CAG>TAG	p.Q4*	AASDH_uc010ihb.2_5'Flank|AASDH_uc011caa.1_5'UTR|AASDH_uc003hbo.2_Intron|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Nonsense_Mutation_p.Q4*|AASDH_uc003hbp.2_Nonsense_Mutation_p.Q4*|AASDH_uc003hbq.1_Nonsense_Mutation_p.Q4*	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	4					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				ACCAATTCCTGAAGAGTCATT	0.418													0	0	0	0.080422	0	39	76										A	57250456	G	A	57250456	4	1	25	1	0	0	0	0	0	1	0	0	22	1299	45	1	3342	1	AASDH	4	57250456	Nonsense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2110646	57250456	133903820	48	6962										
ALB	213	broad.mit.edu	37	chr4	74285275	74285275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aaggcaacaaaagagcaactGaaagctgttatggatgattt	10	5	0	3	rs11538206		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:74285275G>A	uc003hgs.3	+	13	1777	c.1704G>A	c.(1702-1704)CTG>CTA	p.L568L	ALB_uc003hgw.3_Silent_p.L376L|ALB_uc011cbe.1_Silent_p.L247L|ALB_uc003hgt.3_Silent_p.L568L|ALB_uc010iii.2_Silent_p.L453L|ALB_uc003hgu.3_Silent_p.L418L|ALB_uc003hgv.3_Silent_p.L247L|ALB_uc011cbf.1_Silent_p.L458L|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Silent_p.L247L	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	568	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AAGAGCAACTGAAAGCTGTTA	0.413													0	0	0	0.099896	0	28	104										A	74285275	G	A	74285275	2	1	25	1	0	0	0	0	0	0	0	1	486	1277	45	1		1	ALB	4	74285275	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	17034819	74285275	116869001	49	6963										
G3BP2	9908	broad.mit.edu	37	chr4	76570708	76570708	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caccccttggaggaggtcctCttccatcacgatcacgcatc	8	16	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:76570708C>G	uc003hir.2	-	12	1520	c.1355G>C	c.(1354-1356)AGA>ACA	p.R452T	G3BP2_uc003his.2_Missense_Mutation_p.R452T|G3BP2_uc003hit.2_Missense_Mutation_p.R419T	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	452	Gly-rich.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AGGAGGTCCTCTTCCATCACG	0.582													0	0	0	0.069288	0	23	109										G	76570708	C	G	76570708	3	3	25	1	0	0	0	0	1	0	0	0	6142	913	32	1	97	1	G3BP2	4	76570708	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2285433	76570708	114583568	50	6964										
PPEF2	5470	broad.mit.edu	37	chr4	76781888	76781888	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgtgggcattctgaggcatCgccctctgggcaggatttct	13	10	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:76781888C>T	uc003hix.2	-	17	2551	c.2194G>A	c.(2194-2196)GAT>AAT	p.D732N	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	732					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTGAGGCATCGCCCTCTGGG	0.512													0	0	0	0.069288	0	22	64										T	76781888	C	T	76781888	3	4	25	1	0	0	0	0	1	0	0	0	12308	884	31	1	71	1	PPEF2	4	76781888	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	211180	76781888	114372388	51	6965										
PTPN13	5783	broad.mit.edu	37	chr4	87735669	87735669	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgacacgtcttcaagcagaaGaagagcaaaaacagcagcct	9	10	2	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:87735669G>C	uc003hpz.2	+	48	7903	c.7423G>C	c.(7423-7425)GAA>CAA	p.E2475Q	PTPN13_uc003hpy.2_Missense_Mutation_p.E2480Q|PTPN13_uc003hqa.2_Missense_Mutation_p.E2456Q|PTPN13_uc003hqb.2_Missense_Mutation_p.E2284Q	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2475						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAAGCAGAAGAAGAGCAAAA	0.408													0	0	0	0.132662	0	14	29										C	87735669	G	C	87735669	3	2	25	1	0	0	0	0	1	0	0	0	12782	943	33	1	7624	1	PTPN13	4	87735669	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	10953781	87735669	103418607	52	6966										
PPM1K	152926	broad.mit.edu	37	chr4	89199513	89199513	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aatgctgggtggcagcagaaTtggctcatcaatgcggttat	13	7	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:89199513T>C	uc003hrm.3	-	2	613	c.223A>G	c.(223-225)ATT>GTT	p.I75V	PPM1K_uc010ikp.1_Missense_Mutation_p.I75V|PPM1K_uc003hrn.2_Missense_Mutation_p.I75V	NM_152542	NP_689755	Q8N3J5	PPM1K_HUMAN	protein phosphatase 1K (PP2C domain containing)	75					protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		GGCAGCAGAATTGGCTCATCA	0.498													0	0	0	0.125774	0	31	35										C	89199513	T	C	89199513	3	2	25	1	0	0	0	0	1	0	0	0	12343	1493	52	5	919	5	PPM1K	4	89199513	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	1463844	89199513	101954763	53	6967										
CENPE	1062	broad.mit.edu	37	chr4	104103931	104103931	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aaactcacctggagagcagtAagtgtttcatcaaaagatac	8	8	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:104103931A>C	uc003hxb.1	-	11	1041	c.951T>G	c.(949-951)CTT>CTG	p.L317L	CENPE_uc003hxc.1_Silent_p.L317L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	317	Kinesin-motor.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GGAGAGCAGTAAGTGTTTCAT	0.353													0	0	0	0.116897	0	28	141										C	104103931	A	C	104103931	2	2	25	1	0	0	0	0	0	0	0	1	3230	349	13	5		5	CENPE	4	104103931	Silent	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	14904418	104103931	87050345	54	6968										
ARSJ	79642	broad.mit.edu	37	chr4	114899684	114899684	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttcggcagcgagcttgtcaaGagtaggtgttttaatctcag	12	7	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:114899684G>C	uc003ibq.1	-	1	1195	c.307C>G	c.(307-309)CTT>GTT	p.L103V	ARSJ_uc010imu.1_Missense_Mutation_p.L103V|ARSJ_uc010imv.1_5'UTR	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	103						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		AGCTTGTCAAGAGTAGGTGTT	0.458													0	0	0	0.124865	0	48	79										C	114899684	G	C	114899684	3	2	25	1	0	0	0	0	1	0	0	0	995	942	33	1	1500	1	ARSJ	4	114899684	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	10795753	114899684	76254592	55	6969										
PRSS12	8492	broad.mit.edu	37	chr4	119203155	119203155	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctttggtataaacaccaggaGaatccttgactccacagcca	7	12	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:119203155G>T	uc003ica.1	-	13	2611	c.2564C>A	c.(2563-2565)TCT>TAT	p.S855Y		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	855	Peptidase S1.					membrane	scavenger receptor activity			skin(1)	1						AACACCAGGAGAATCCTTGAC	0.488													1	0	2.98393e-07	0.076483	3.0983e-07	22	91										T	119203155	G	T	119203155	3	4	25	1	0	0	0	0	1	0	0	0	12615	942	33	3	67	3	PRSS12	4	119203155	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	4303471	119203155	71951121	56	6970										
LRBA	987	broad.mit.edu	37	chr4	151771938	151771938	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcagtgagcaaacgttgatgCatctgagaccagttgaactc	10	9	2	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:151771938C>T	uc010ipj.2	-	24	4416	c.3942G>A	c.(3940-3942)ATG>ATA	p.M1314I	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Missense_Mutation_p.M1314I	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1314	WD 1.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					AACGTTGATGCATCTGAGACC	0.393													0	0	0	0.146539	0	17	90										T	151771938	C	T	151771938	3	4	25	1	0	0	0	0	1	0	0	0	8931	710	25	2	4789	2	LRBA	4	151771938	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	32568783	151771938	39382338	57	6971										
TLR2	7097	broad.mit.edu	37	chr4	154625550	154625550	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	actctaccagatgcctccctCttacccatgttactagtatt	4	14	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:154625550C>G	uc003inq.2	+	3	1710	c.1491C>G	c.(1489-1491)CTC>CTG	p.L497L	TLR2_uc003inr.2_Silent_p.L497L|TLR2_uc003ins.2_Silent_p.L497L	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	497	LRR 13.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				ATGCCTCCCTCTTACCCATGT	0.358													0	0	0	0.083992	0	22	112										G	154625550	C	G	154625550	2	3	25	1	0	0	0	0	0	0	0	1	15948	900	32	1		1	TLR2	4	154625550	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2853612	154625550	36528726	58	6972										
GRIA2	2891	broad.mit.edu	37	chr4	158142864	158142864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcaagaatacagtgcatttcGagtagggatggttcagtttt	11	5	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:158142864G>A	uc003ipm.3	+	2	593	c.134G>A	c.(133-135)CGA>CAA	p.R45Q	GRIA2_uc011cit.1_5'UTR|GRIA2_uc003ipl.3_Missense_Mutation_p.R45Q|GRIA2_uc003ipk.3_5'UTR|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	45	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGTGCATTTCGAGTAGGGATG	0.507													0	0	0	0.080422	0	36	130										A	158142864	G	A	158142864	3	1	25	1	0	0	0	0	1	0	0	0	6768	1058	37	1	140	1	GRIA2	4	158142864	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	3517314	158142864	33011412	59	6973										
PDLIM3	27295	broad.mit.edu	37	chr4	186425667	186425667	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgtcacagagcggcatcctCtgtgccccgcctgaaccgcc	10	17	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:186425667C>G	uc003ixw.3	-	7	991	c.867G>C	c.(865-867)CAG>CAC	p.Q289H	PDLIM3_uc003ixx.3_Missense_Mutation_p.Q241H|PDLIM3_uc010isi.2_RNA	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	289						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GCGGCATCCTCTGTGCCCCGC	0.507													0	0	0	0.0333	0	15	59										G	186425667	C	G	186425667	3	3	25	1	0	0	0	0	1	0	0	0	11681	912	32	1	235	1	PDLIM3	4	186425667	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	28282803	186425667	4728609	60	6974										
MED10	84246	broad.mit.edu	37	chr5	6378552	6378552	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agctgccgaatgttctccacGaacttctccaggtgctcctc	8	15	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:6378552G>A	uc003jdo.2	-	1	88	c.45C>T	c.(43-45)TTC>TTT	p.F15F		NM_032286	NP_115662	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	15					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(1)	1						TGTTCTCCACGAACTTCTCCA	0.652													0	0	0	0.076483	0	23	14										A	6378552	G	A	6378552	2	1	25	1	0	0	0	0	0	0	0	1	9426	1049	37	1		1	MED10	5	6378552	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		6378552	174536708	61	6975										
ADAMTS12	81792	broad.mit.edu	37	chr5	33614349	33614349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagctgtttctcacctgtccCgcaggtcacactgcactctg	8	16	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:33614349C>T	uc003jia.1	-	16	2684	c.2521G>A	c.(2521-2523)GGG>AGG	p.G841R	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G756R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	841	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCACCTGTCCCGCAGGTCACA	0.507										HNSCC(64;0.19)			0	0	0	0.146539	0	17	34										T	33614349	C	T	33614349	3	4	25	1	0	0	0	0	1	0	0	0	257	652	23	2	2299	2	ADAMTS12	5	33614349	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	27235797	33614349	147300911	62	6976										
HCN1	348980	broad.mit.edu	37	chr5	45262237	45262237	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggcccgttccggggaccgccGtcacgggttgagggatggag	19	11	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:45262237G>A	uc003jok.2	-	8	2484	c.2459C>T	c.(2458-2460)ACG>ATG	p.T820M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	820	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GGGGACCGCCGTCACGGGTTG	0.677													0	0	0	0.074837	0	36	37										A	45262237	G	A	45262237	3	1	25	1	0	0	0	0	1	0	0	0	6996	1145	40	2	217	2	HCN1	5	45262237	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	11647888	45262237	135653023	63	6977										
GPR98	84059	broad.mit.edu	37	chr5	89948215	89948215	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tttctgtatcttggcagctcTttcagaatgattctgctttg	8	8	5	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:89948215T>C	uc003kju.2	+	19	3565	c.3469T>C	c.(3469-3471)TTT>CTT	p.F1157L	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1157	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGGCAGCTCTTTCAGAATGA	0.373													0	0	0	0.125774	0	21	116										C	89948215	T	C	89948215	3	2	25	1	0	0	0	0	1	0	0	0	6721	1609	56	5	3543	5	GPR98	5	89948215	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	44685978	89948215	90967045	64	6978										
PCDHA7	56141	broad.mit.edu	37	chr5	140215250	140215250	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atgagctggtggttaccgcgCgggacgggggctcgccttct	17	11	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:140215250C>T	uc003lhq.2	+	1	1282	c.1282C>T	c.(1282-1284)CGG>TGG	p.R428W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.R428W	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	428	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTACCGCGCGGGACGGGGG	0.617													0	0	0	0.139131	0	43	99										T	140215250	C	T	140215250	3	4	25	1	0	0	0	0	1	0	0	0	11529	759	27	2	1284	2	PCDHA7	5	140215250	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	50267035	140215250	40700010	65	6979										
PCDHA13	56136	broad.mit.edu	37	chr5	140263524	140263524	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgcaggtgttcgtgctggaCgagaacgacaacgctccggc	14	12	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:140263524C>T	uc003lif.2	+	1	1671	c.1671C>T	c.(1669-1671)GAC>GAT	p.D557D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.D557D|PCDHA13_uc003lid.2_Silent_p.D557D	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	557	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGCTGGACGAGAACGACA	0.697													0	0	0	0.139131	0	67	40										T	140263524	C	T	140263524	2	4	25	1	0	0	0	0	0	0	0	1	11523	535	19	2		2	PCDHA13	5	140263524	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	48274	140263524	40651736	66	6980										
ADRA1B	147	broad.mit.edu	37	chr5	159344642	159344642	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tagaggcaggagtcatgaagGagatgtccaactccaaggag	14	7	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:159344642G>C	uc003lxt.1	+	1	903	c.730G>C	c.(730-732)GAG>CAG	p.E244Q		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	244	Cytoplasmic (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	AGTCATGAAGGAGATGTCCAA	0.527													0	0	0	0.139131	0	75	23										C	159344642	G	C	159344642	3	2	25	1	0	0	0	0	1	0	0	0	335	1175	41	1	732	1	ADRA1B	5	159344642	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	19081118	159344642	21570618	67	6981										
ZNF354B	117608	broad.mit.edu	37	chr5	178310385	178310385	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taaatccttcagtcgaaggtCtgggctttttatacatcaaa	7	8	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:178310385C>T	uc003mjl.2	+	5	1158	c.932C>T	c.(931-933)TCT>TTT	p.S311F	ZNF354B_uc003mjm.2_Missense_Mutation_p.S311F	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	311	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTCGAAGGTCTGGGCTTTTT	0.418													0	0	0	0.0333	0	18	34										T	178310385	C	T	178310385	3	4	25	1	0	0	0	0	1	0	0	0	17862	913	32	1	946	1	ZNF354B	5	178310385	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	18965743	178310385	2604875	68	6982										
ZNF184	7738	broad.mit.edu	37	chr6	27420988	27420988	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctggagatagctcttcttcaGaaatgtcaggctctggggct	12	9	5	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:27420988G>A	uc003njj.2	-	5	1161	c.350C>T	c.(349-351)TCT>TTT	p.S117F	ZNF184_uc010jqv.2_Missense_Mutation_p.S117F|ZNF184_uc003nji.2_Missense_Mutation_p.S117F	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTCTTCTTCAGAAATGTCAGG	0.373													0	0	0	0.117977	0	44	119										A	27420988	G	A	27420988	3	1	25	1	0	0	0	0	1	0	0	0	17748	942	33	1	1909	1	ZNF184	6	27420988	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		27420988	143694079	69	6983										
GTPBP2	54676	broad.mit.edu	37	chr6	43593965	43593965	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggggaaggggaagcatacttCtctgccatccggtgcagggt	16	9	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:43593965C>G	uc003ovs.2	-	3	433	c.396G>C	c.(394-396)GAG>GAC	p.E132D	GTPBP2_uc010jyv.2_Missense_Mutation_p.E44D|GTPBP2_uc003ovt.1_Missense_Mutation_p.E132D	NM_019096	NP_061969	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	132							GTP binding|GTPase activity			liver(1)|skin(1)	2	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AAGCATACTTCTCTGCCATCC	0.592													0	0	0	0.059317	0	32	107										G	43593965	C	G	43593965	3	3	25	1	0	0	0	0	1	0	0	0	6880	912	32	1	1452	1	GTPBP2	6	43593965	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	16172977	43593965	127521102	70	6984										
SLC25A27	9481	broad.mit.edu	37	chr6	46644165	46644165	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttacttatgaaaaaatcagaGagatgagtggagtcagtcca	10	5	2	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:46644165G>C	uc003oyh.2	+	9	1197	c.946G>C	c.(946-948)GAG>CAG	p.E316Q	SLC25A27_uc011dwb.1_Intron|SLC25A27_uc003oyg.2_Intron|SLC25A27_uc011dwc.1_Missense_Mutation_p.E230Q|SLC25A27_uc003oyi.2_Missense_Mutation_p.E246Q	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	316	Solcar 3.				generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			AAAAATCAGAGAGATGAGTGG	0.368													0	0	0	0.144211	0	29	43										C	46644165	G	C	46644165	3	2	25	1	0	0	0	0	1	0	0	0	14490	943	33	1	980	1	SLC25A27	6	46644165	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	3050200	46644165	124470902	71	6985										
PAQR8	85315	broad.mit.edu	37	chr6	52268632	52268632	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taccggaggccttatccagtCatgaggaagatctgtcaagt	11	9	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:52268632C>T	uc003pao.3	+	2	795	c.621C>T	c.(619-621)GTC>GTT	p.V207V		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	207	Extracellular (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					CTTATCCAGTCATGAGGAAGA	0.547													0	0	0	0.139131	0	48	51										T	52268632	C	T	52268632	2	4	25	1	0	0	0	0	0	0	0	1	11441	813	29	1		1	PAQR8	6	52268632	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	5624467	52268632	118846435	72	6986										
BCLAF1	9774	broad.mit.edu	37	chr6	136599241	136599241	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgaatggaatgtgaatgctGagaaggagtattttttgcag	13	3	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:136599241G>C	uc003qgx.1	-	4	1031	c.778C>G	c.(778-780)CAG>GAG	p.Q260E	BCLAF1_uc003qgw.1_Missense_Mutation_p.Q260E|BCLAF1_uc003qgy.1_Missense_Mutation_p.Q258E|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.Q258E	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	260					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGTGAATGCTGAGAAGGAGTA	0.443													0	0	0	0.058154	0	10	71										C	136599241	G	C	136599241	3	2	25	1	0	0	0	0	1	0	0	0	1383	1299	45	1	2024	1	BCLAF1	6	136599241	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	84330609	136599241	34515826	73	6987										
WTAP	9589	broad.mit.edu	37	chr6	160174506	160174506	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgcagccaaacagggaaaaAgttaatggcgaagtgtcgaa	12	6	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:160174506A>G	uc003qsl.2	+	7	689	c.467A>G	c.(466-468)AAG>AGG	p.K156R	WTAP_uc003qso.2_Missense_Mutation_p.K37R	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	156					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		ACAGGGAAAAAGTTAATGGCG	0.423													0	0	0	0.02938	0	7	65										G	160174506	A	G	160174506	3	3	25	1	0	0	0	0	1	0	0	0	17406	72	3	5	493	5	WTAP	6	160174506	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	23575265	160174506	10940561	74	6988										
TNRC18	84629	broad.mit.edu	37	chr7	5352441	5352441	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggggagcgccgcctgcgcgGaagggccagccgtgggggcg	22	12	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:5352441G>A	uc003soi.3	-	27	8430	c.8081C>T	c.(8080-8082)TCC>TTC	p.S2694F		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2694							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGCCTGCGCGGAAGGGCCAGC	0.622													0	0	0	0.014758	0	5	13										A	5352441	G	A	5352441	3	1	25	1	0	0	0	0	1	0	0	0	16336	1174	41	1	841	1	TNRC18	7	5352441	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		5352441	153786222	75	6989										
EPDR1	54749	broad.mit.edu	37	chr7	37960368	37960368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggtcccggctaccgggactCgcgcgtccggatctcaaaag	13	14	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:37960368C>T	uc003tfp.2	+	1	206	c.187C>T	c.(187-189)CGC>TGC	p.R63C	EPDR1_uc003tfq.2_Missense_Mutation_p.R63C|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	Error:Variant_position_missing_in_Q9UM22_after_alignment					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						TACCGGGACTCGCGCGTCCGG	0.672													0	0	0	0.080422	0	29	13										T	37960368	C	T	37960368	3	4	25	1	0	0	0	0	1	0	0	0	5163	884	31	1	189	1	EPDR1	7	37960368	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	32607927	37960368	121178295	76	6990										
ZMIZ2	83637	broad.mit.edu	37	chr7	44796036	44796036	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccctgcagtgatggttcattCgcatatgagtctgtgccttg	11	10	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:44796036C>T	uc003tlr.2	+	3	186	c.63C>T	c.(61-63)TTC>TTT	p.F21F	ZMIZ2_uc003tlq.2_Silent_p.F21F|ZMIZ2_uc003tls.2_Silent_p.F21F	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	21					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						ATGGTTCATTCGCATATGAGT	0.577													0	0	0	0.139131	0	80	46										T	44796036	C	T	44796036	2	4	25	1	0	0	0	0	0	0	0	1	17694	883	31	1		1	ZMIZ2	7	44796036	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	6835668	44796036	114342627	77	6991										
HIP1	3092	broad.mit.edu	37	chr7	75203167	75203167	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggcggcactgccctgctgccGtcacggacacagagcgggac	15	15	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:75203167G>C	uc003uds.1	-	8	685	c.644C>G	c.(643-645)ACG>AGG	p.T215R	HIP1_uc011kfz.1_Missense_Mutation_p.T92R	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	215					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CCCTGCTGCCGTCACGGACAC	0.547			T	PDGFRB	CMML								0	0	0	0.021553	0	6	97										C	75203167	G	C	75203167	3	2	25	1	0	0	0	0	1	0	0	0	7114	1145	40	4	2565	4	HIP1	7	75203167	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	30407131	75203167	83935496	78	6992										
SEMA3C	10512	broad.mit.edu	37	chr7	80374329	80374329	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tccctgctgatgttgctgccGagtgtctttgcaatattggt	11	9	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:80374329G>A	uc003uhj.2	-	18	2699	c.2137C>T	c.(2137-2139)CGG>TGG	p.R713W	SEMA3C_uc011kgw.1_Missense_Mutation_p.R731W	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	713					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TGTTGCTGCCGAGTGTCTTTG	0.483													0	0	0	0.080422	0	39	161										A	80374329	G	A	80374329	3	1	25	1	0	0	0	0	1	0	0	0	14026	1057	37	1	122	1	SEMA3C	7	80374329	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	5171162	80374329	78764334	79	6993										
CDK6	1021	broad.mit.edu	37	chr7	92462586	92462586	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ataggcgccctccccgatctCcgccacgcattcgtactgct	8	18	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:92462586C>T	uc011khw.1	-	2	464	c.52G>A	c.(52-54)GAG>AAG	p.E18K	CDK6_uc010lez.2_Missense_Mutation_p.E18K	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	18	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCCCCGATCTCCGCCACGCAT	0.537			T	MLLT10	ALL								0	0	0	0.0333	0	16	13										T	92462586	C	T	92462586	3	4	25	1	0	0	0	0	1	0	0	0	3148	864	30	1	956	1	CDK6	7	92462586	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	12088257	92462586	66676077	80	6994										
SAMD9	54809	broad.mit.edu	37	chr7	92732940	92732940	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcaccagaggtttttcatatCgaatgtactttttagctata	6	7	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:92732940C>G	uc003umf.2	-	3	2727	c.2471G>C	c.(2470-2472)CGA>CCA	p.R824P	SAMD9_uc003umg.2_Missense_Mutation_p.R824P	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	824						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTTCATATCGAATGTACTT	0.358													0	0	0	0.083992	0	26	119										G	92732940	C	G	92732940	3	3	25	1	0	0	0	0	1	0	0	0	13826	884	31	1	2302	1	SAMD9	7	92732940	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	270354	92732940	66405723	81	6995										
AGFG2	3268	broad.mit.edu	37	chr7	100148019	100148022	+	Frame_Shift_Del	DEL	GTTT	GTTT	-													0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgacaccttcattcttttagGtttgccggaagatttggttg							TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:100148019_100148022delGTTT	uc003uvf.2	+	3	452_455	c.316_319delGTTT	c.(316-321)GTTTGCfs	p.V106fs	AGFG2_uc003uvg.1_Frame_Shift_Del_p.V106fs|AGFG2_uc010lgy.2_5'UTR	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	106_107	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						ATTCTTTTAGGTTTGCCGGAAGAT	0.348																		163	137	---	---								-	100148022	GTTT	-	100148019	7	5	25	1	0	1	0	1	0	0	0	0	381	1275	44	0	326	0	AGFG2	7	100148019	Frame_Shift_Del	DEL	GTTT	TCGA-C4-A0F6-01A-11D-A10S-08	7415079	100148019	58990644	82	6996										
SLC26A3	1811	broad.mit.edu	37	chr7	107423661	107423661	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tttacttacctgattgccatCaagtggataatcgtatttga	7	7	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:107423661C>G	uc003ver.2	-	9	1319	c.1108G>C	c.(1108-1110)GAT>CAT	p.D370H	SLC26A3_uc003ves.2_Missense_Mutation_p.D335H	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	370					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TGATTGCCATCAAGTGGATAA	0.423													0	0	0	0.139131	0	68	77										G	107423661	C	G	107423661	3	3	25	1	0	0	0	0	1	0	0	0	14518	826	29	1	1238	1	SLC26A3	7	107423661	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	7275642	107423661	51715002	83	6997										
DOCK4	9732	broad.mit.edu	37	chr7	111508111	111508111	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	acggactgacatgagaagctCctgaatgcagcagcggaact	12	10	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:111508111C>T	uc003vfx.2	-	22	2478	c.2209G>A	c.(2209-2211)GAG>AAG	p.E737K	DOCK4_uc003vfw.2_Missense_Mutation_p.E178K|DOCK4_uc003vfy.2_Missense_Mutation_p.E737K|DOCK4_uc003vga.1_Missense_Mutation_p.E342K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	737					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ATGAGAAGCTCCTGAATGCAG	0.433													0	0	0	0.058154	0	9	42										T	111508111	C	T	111508111	3	4	25	1	0	0	0	0	1	0	0	0	4689	864	30	1	3815	1	DOCK4	7	111508111	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	4084450	111508111	47630552	84	6998										
FLNC	2318	broad.mit.edu	37	chr7	128492642	128492651	+	Splice_Site	DEL	CAGGTGATGA	CAGGTGATGA	-													0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgatgccccaactcccccacCaggtgatgactccatgagga							TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:128492642_128492651delCAGGTGATGA	uc003vnz.3	+	36	6052	c.5843_splice	c.e36-1	p.G1948_splice	FLNC_uc003voa.3_Splice_Site_p.G1915_splice	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a						cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						ACTCCCCCACCAGGTGATGACTCCATGAGG	0.624																		15	191	---	---								-	128492651	CAGGTGATGA	-	128492642	8	5	25	1	0	1	0	1	0	0	1	0	5935	609	21	0		0	FLNC	7	128492642	Splice_Site	DEL	CAGGTGATGA	TCGA-C4-A0F6-01A-11D-A10S-08	16984531	128492642	30646021	85	6999										
TPK1	27010	broad.mit.edu	37	chr7	144245674	144245674	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atcaccctccattccagtgtCtacatgcaacctgtgctttc	5	15	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:144245674C>T	uc003weq.2	-	8	626	c.523G>A	c.(523-525)GAC>AAC	p.D175N	TPK1_uc003weo.2_Missense_Mutation_p.D121N|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.D126N|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	175					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	ATTCCAGTGTCTACATGCAAC	0.473													0	0	0	0.050027	0	33	148										T	144245674	C	T	144245674	3	4	25	1	0	0	0	0	1	0	0	0	16401	913	32	1	216	1	TPK1	7	144245674	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	15753032	144245674	14892989	86	7000										
INTS9	55756	broad.mit.edu	37	chr8	28633422	28633422	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gggcggctgagtgtactgctCaggacacaccacgtgcaggg	16	11	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:28633422C>T	uc003xha.2	-	14	1716	c.1417G>A	c.(1417-1419)GAG>AAG	p.E473K	INTS9_uc011lav.1_Missense_Mutation_p.E449K|INTS9_uc011law.1_Missense_Mutation_p.E452K|INTS9_uc011lax.1_Missense_Mutation_p.E366K|INTS9_uc010lvc.2_RNA	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	473					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		GTGTACTGCTCAGGACACACC	0.622													0	0	0	0.0918	0	24	56										T	28633422	C	T	28633422	3	4	25	1	0	0	0	0	1	0	0	0	7785	835	29	1	575	1	INTS9	8	28633422	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		28633422	117730600	87	7001										
VPS13B	157680	broad.mit.edu	37	chr8	100833675	100833675	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aagaagcgtttgttgatactGaaataagacttggtgctttt	10	4	0	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:100833675G>C	uc003yiv.2	+	50	9334	c.9223G>C	c.(9223-9225)GAA>CAA	p.E3075Q	VPS13B_uc003yiw.2_Missense_Mutation_p.E3050Q	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3075					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGTTGATACTGAAATAAGACT	0.418													0	0	0	0.076483	0	22	146										C	100833675	G	C	100833675	3	2	25	1	0	0	0	0	1	0	0	0	17187	1291	45	1	9611	1	VPS13B	8	100833675	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	72200253	100833675	45530347	88	7002										
UBR5	51366	broad.mit.edu	37	chr8	103335546	103335546	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctatagtacttacttagcttCagtagttttgctagcttttt	6	7	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:103335546C>T	uc003ykr.1	-	14	1810	c.1777G>A	c.(1777-1779)GAA>AAA	p.E593K	UBR5_uc003yks.1_Missense_Mutation_p.E593K	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	593					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TACTTAGCTTCAGTAGTTTTG	0.368													0	0	0	0.047766	0	7	54										T	103335546	C	T	103335546	3	4	25	1	0	0	0	0	1	0	0	0	16902	835	29	1	6806	1	UBR5	8	103335546	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2501871	103335546	43028476	89	7003										
TG	7038	broad.mit.edu	37	chr8	133906095	133906095	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaggacctcggccttcctccGctcttcccgccccgggaggc	12	19	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:133906095G>A	uc003ytw.2	+	11	2963	c.2922G>A	c.(2920-2922)CCG>CCA	p.P974P		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	974	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCCTTCCTCCGCTCTTCCCGC	0.602													0	0	0	0.144211	0	31	168										A	133906095	G	A	133906095	2	1	25	1	0	0	0	0	0	0	0	1	15810	1074	38	2		2	TG	8	133906095	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	30570549	133906095	12457927	90	7004										
VLDLR	7436	broad.mit.edu	37	chr9	2652927	2652927	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cattggtagacacagtgcttCtgttggacacacgtacccag	10	11	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:2652927C>G	uc003zhk.1	+	18	2961	c.2564C>G	c.(2563-2565)TCT>TGT	p.S855C	VLDLR_uc003zhl.1_Missense_Mutation_p.S827C|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.S786C	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	855	Cytoplasmic (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		CACAGTGCTTCTGTTGGACAC	0.448													0	0	0	0.139131	0	72	81										G	2652927	C	G	2652927	3	3	25	1	0	0	0	0	1	0	0	0	17171	913	32	1	2634	1	VLDLR	9	2652927	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		2652927	138560504	91	7005										
C9orf102	375748	broad.mit.edu	37	chr9	98690414	98690414	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aacagagataaagttcttctCttttctttttccaccaaggt	5	9	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:98690414C>G	uc004avt.3	+	10	2008	c.1620C>G	c.(1618-1620)CTC>CTG	p.L540L	C9orf102_uc010mrx.1_Intron|C9orf102_uc011lum.1_Silent_p.L242L|C9orf102_uc010mry.1_Silent_p.L242L|C9orf102_uc010mrz.2_Silent_p.L351L|C9orf102_uc004avu.2_Intron	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	540	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				aagttcttctcttttcttttt	0													0	0	0	0.0918	0	25	42										G	98690414	C	G	98690414	2	3	25	1	0	0	0	0	0	0	0	1	2445	900	32	1		1	C9orf102	9	98690414	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	96037487	98690414	42523017	92	7006										
CORO2A	7464	broad.mit.edu	37	chr9	100888882	100888882	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aaaacgtcaaagccatttgtCagccaggttttcttctcctc	6	12	4	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:100888882C>G	uc004ayl.2	-	11	1661	c.1395G>C	c.(1393-1395)CTG>CTC	p.L465L	CORO2A_uc004aym.2_Silent_p.L465L|CORO2A_uc004ayk.2_Silent_p.L112L	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	465					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				AGCCATTTGTCAGCCAGGTTT	0.567													0	0	0	0.139131	0	64	152										G	100888882	C	G	100888882	2	3	25	1	0	0	0	0	0	0	0	1	3756	813	29	1		1	CORO2A	9	100888882	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2198468	100888882	40324549	93	7007										
SVEP1	79987	broad.mit.edu	37	chr9	113213596	113213596	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcctttcacacatgtgcaacGatagccagccacaccatcaa	5	15	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:113213596G>A	uc010mtz.2	-	23	4211	c.3874C>T	c.(3874-3876)CGT>TGT	p.R1292C	SVEP1_uc010mua.1_Missense_Mutation_p.R1292C	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1292	EGF-like 3; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CATGTGCAACGATAGCCAGCC	0.373													0	0	0	0.134883	0	30	14										A	113213596	G	A	113213596	3	1	25	1	0	0	0	0	1	0	0	0	15417	1058	37	1	6945	1	SVEP1	9	113213596	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	12324714	113213596	27999835	94	7008										
NUP188	23511	broad.mit.edu	37	chr9	131721315	131721315	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgaatatgcagactgtgttGataaattggagaaggaacta	11	3	0	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:131721315G>C	uc004bws.1	+	8	509	c.487G>C	c.(487-489)GAT>CAT	p.D163H		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	163					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						AGACTGTGTTGATAAATTGGA	0.284													0	0	0	0.116897	0	29	45										C	131721315	G	C	131721315	3	2	25	1	0	0	0	0	1	0	0	0	10758	1290	45	1	517	1	NUP188	9	131721315	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	18507719	131721315	9492116	95	7009										
FNBP1	23048	broad.mit.edu	37	chr9	132658259	132658259	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tctccttcaactacggaaatCgttccttcattctgacctga	5	13	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:132658259C>T	uc004byw.1	-	16	1923	c.1704G>A	c.(1702-1704)ACG>ACA	p.T568T	FNBP1_uc011mbv.1_Silent_p.T558T|FNBP1_uc011mbw.1_Silent_p.T563T|FNBP1_uc004bza.2_Silent_p.T502T|FNBP1_uc004byz.1_Silent_p.T539T|FNBP1_uc004byv.1_5'Flank|FNBP1_uc011mbu.1_Silent_p.T196T|FNBP1_uc004byx.1_Silent_p.T484T|FNBP1_uc004byy.1_Silent_p.T474T	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	568	Required for self-association and induction of membrane tubulation.|Interaction with FASLG.|SH3.|Interaction with PDE6G (By similarity).|Interaction with DNM1 and DNM3.|Required for interaction with TNKS.|Interaction with DNM2 and WASL.|Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		CTACGGAAATCGTTCCTTCAT	0.443			T	MLL	AML								0	0	0	0.0918	0	22	49										T	132658259	C	T	132658259	2	4	25	1	0	0	0	0	0	0	0	1	5965	871	31	1		1	FNBP1	9	132658259	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	936944	132658259	8555172	96	7010										
DDX31	64794	broad.mit.edu	37	chr9	135545428	135545428	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgcgccaccgccccttccgGgtccggaacggctccagctg	12	19	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:135545428G>A	uc004cbq.1	-	1	361	c.209C>T	c.(208-210)CCC>CTC	p.P70L	DDX31_uc010mzu.1_Missense_Mutation_p.P70L|DDX31_uc004cbr.1_Missense_Mutation_p.P70L|DDX31_uc004cbs.1_Missense_Mutation_p.P70L|GTF3C4_uc010mzv.2_5'Flank|GTF3C4_uc010mzw.2_5'Flank	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	70						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		GCCCCTTCCGGGTCCGGAACG	0.761													0	0	0	0.115264	0	2	1										A	135545428	G	A	135545428	3	1	25	1	0	0	0	0	1	0	0	0	4356	1232	43	2	2433	2	DDX31	9	135545428	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2887169	135545428	5668003	97	7011										
RXRA	6256	broad.mit.edu	37	chr9	137300844	137300844	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggcttcttcaagcggacggtGcgcaaggacctgacctacac	12	13	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:137300844G>A	uc004cfb.2	+	4	651	c.489G>A	c.(487-489)GTG>GTA	p.V163V	RXRA_uc004cfc.1_Silent_p.V66V	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	163	Nuclear receptor.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	AGCGGACGGTGCGCAAGGACC	0.642													0	0	0	0.139131	0	64	32										A	137300844	G	A	137300844	2	1	25	1	0	0	0	0	0	0	0	1	13763	1306	46	2		2	RXRA	9	137300844	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1755416	137300844	3912587	98	7012										
NOTCH1	4851	broad.mit.edu	37	chr9	139391498	139391498	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggcatcccaggcaggtggttGaggggcacggacggagactg	19	9	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:139391498G>C	uc004chz.2	-	34	6693	c.6693C>G	c.(6691-6693)CTC>CTG	p.L2231L		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2231	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGGTGGTTGAGGGGCACGG	0.721			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.11911	0	12	16										C	139391498	G	C	139391498	2	2	25	1	0	0	0	0	0	0	0	1	10547	1277	45	1		1	NOTCH1	9	139391498	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2090654	139391498	1821933	99	7013										
ENTPD2	954	broad.mit.edu	37	chr9	139945421	139945421	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agcagaggaagctgtgggtgTagactcggtagtgctggccg	18	7	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:139945421T>C	uc004ckw.1	-	5	763	c.707A>G	c.(706-708)TAC>TGC	p.Y236C	ENTPD2_uc004ckv.1_5'Flank|ENTPD2_uc004ckx.1_Missense_Mutation_p.Y236C	NM_203468	NP_982293	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	236	Extracellular (Potential).					integral to membrane	ATP binding				0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCTGTGGGTGTAGACTCGGTA	0.632													0	0	0	0.105934	0	6	23										C	139945421	T	C	139945421	3	2	25	1	0	0	0	0	1	0	0	0	5139	1638	57	5	800	5	ENTPD2	9	139945421	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	553923	139945421	1268010	100	7014										
SFMBT2	57713	broad.mit.edu	37	chr10	7205753	7205753	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagttggcgtactgggcgtaGaaagccactttgactctctc	11	11	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:7205753G>C	uc009xio.1	-	21	2755	c.2664C>G	c.(2662-2664)TTC>TTG	p.F888L	SFMBT2_uc001ijn.1_Missense_Mutation_p.F888L|SFMBT2_uc010qay.1_Missense_Mutation_p.F723L	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	888					regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						ACTGGGCGTAGAAAGCCACTT	0.547													0	0	0	0.076483	0	23	70										C	7205753	G	C	7205753	3	2	25	1	0	0	0	0	1	0	0	0	14158	933	33	1	24	1	SFMBT2	10	7205753	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		7205753	128328994	101	7015										
GAD2	2572	broad.mit.edu	37	chr10	26581833	26581833	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttcctttcctctttgtagccTcagcacacaaatgtctgctt	5	13	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:26581833T>C	uc001isp.2	+	15	2000	c.1497T>C	c.(1495-1497)CCT>CCC	p.P499P	GAD2_uc001isq.2_Silent_p.P499P	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	499					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CTTTGTAGCCTCAGCACACAA	0.448													0	0	0	0.139131	0	116	281										C	26581833	T	C	26581833	2	2	25	1	0	0	0	0	0	0	0	1	6180	1538	54	5		5	GAD2	10	26581833	Silent	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	19376080	26581833	108952914	102	7016										
ANUBL1	93550	broad.mit.edu	37	chr10	46121537	46121537	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtgctctgtaatctatttctGcttgtgctcccggccagtga	10	11	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:46121537G>T	uc001jcp.3	-	7	1976	c.1734C>A	c.(1732-1734)AGC>AGA	p.S578R	ANUBL1_uc001jcl.3_Missense_Mutation_p.S98R|ANUBL1_uc001jcm.3_Missense_Mutation_p.S578R|ANUBL1_uc009xmu.2_Missense_Mutation_p.S504R|ANUBL1_uc001jcn.3_Missense_Mutation_p.S504R|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	578							zinc ion binding				0						ATCTATTTCTGCTTGTGCTCC	0.468													1	0	0.00909568	0.009096	0.00937894	4	146										T	46121537	G	T	46121537	3	4	25	1	0	0	0	0	1	0	0	0	713	1310	46	4	465	4	ANUBL1	10	46121537	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	19539704	46121537	89413210	103	7017										
RBP3	5949	broad.mit.edu	37	chr10	48382225	48382225	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggccgtcacactgctggtcaGaatgaccatgctcttcttgg	11	12	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:48382225G>C	uc001jez.2	-	4	3538	c.3424C>G	c.(3424-3426)CTG>GTG	p.L1142V		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	1142	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTGCTGGTCAGAATGACCATG	0.592													0	0	0	0.043863	0	19	32										C	48382225	G	C	48382225	3	2	25	1	0	0	0	0	1	0	0	0	13157	933	33	1	323	1	RBP3	10	48382225	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2260688	48382225	87152522	104	7018										
PLCE1	51196	broad.mit.edu	37	chr10	96064271	96064271	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atttaaatgctgcaatgtttGaggcaaatggtggttgtggt	13	3	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:96064271G>A	uc001kjk.2	+	25	6125	c.5491G>A	c.(5491-5493)GAG>AAG	p.E1831K	PLCE1_uc010qnx.1_Missense_Mutation_p.E1815K|PLCE1_uc001kjm.2_Missense_Mutation_p.E1523K|PLCE1_uc001kjp.2_Missense_Mutation_p.E189K	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1831	PI-PLC Y-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TGCAATGTTTGAGGCAAATGG	0.378													0	0	0	0.139131	0	72	136										A	96064271	G	A	96064271	3	1	25	1	0	0	0	0	1	0	0	0	12034	1291	45	1	5871	1	PLCE1	10	96064271	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	47682046	96064271	39470476	105	7019										
PKP3	11187	broad.mit.edu	37	chr11	397293	397293	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caccggagccgcggggtaggCggggcagtgccgggggccgt	22	12	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:397293C>T	uc001lpc.2	+	3	868	c.792C>T	c.(790-792)GGC>GGT	p.G264G		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	264					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCGGGGTAGGCGGGGCAGTGC	0.736													0	0	0	0.009096	0	4	2										T	397293	C	T	397293	2	4	25	1	0	0	0	0	0	0	0	1	11986	755	27	2		2	PKP3	11	397293	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		397293	134609223	106	7020										
PGAP2	27315	broad.mit.edu	37	chr11	3845209	3845209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcggcctgcactcggcgcctCgcttcttggtggccttcgcc	12	17	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:3845209C>T	uc001lys.2	+	4	571	c.445C>T	c.(445-447)CGC>TGC	p.R149C	PGAP2_uc001lyl.2_Missense_Mutation_p.R106C|PGAP2_uc010qxw.1_Missense_Mutation_p.R206C|PGAP2_uc010qxx.1_Missense_Mutation_p.S129L|PGAP2_uc001lyp.3_Intron|PGAP2_uc010qxy.1_Missense_Mutation_p.R145C|PGAP2_uc010qxz.1_Missense_Mutation_p.R145C|PGAP2_uc001lyn.3_Missense_Mutation_p.S41L|PGAP2_uc010qya.1_RNA|PGAP2_uc001lyr.2_Missense_Mutation_p.R88C|PGAP2_uc010qyb.1_Missense_Mutation_p.S91L|PGAP2_uc001lyt.2_5'UTR	NM_014489	NP_055304	Q9UHJ9	PGAP2_HUMAN	FGF receptor activating protein 1 isoform 1	149					GPI anchor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein transporter activity				0						CTCGGCGCCTCGCTTCTTGGT	0.642													0	0	0	0.069288	0	22	63										T	3845209	C	T	3845209	3	4	25	1	0	0	0	0	1	0	0	0	11778	893	31	1	634	1	PGAP2	11	3845209	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	3447916	3845209	131161307	107	7021										
NLRP14	338323	broad.mit.edu	37	chr11	7079046	7079046	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagcttttgtgtgaggccttAagacatccaaagtgttatct	9	8	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:7079046A>C	uc001mfb.1	+	7	2753	c.2430A>C	c.(2428-2430)TTA>TTC	p.L810F		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	810					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GTGAGGCCTTAAGACATCCAA	0.393													0	0	0	0.099896	0	25	45										C	7079046	A	C	7079046	3	2	25	1	0	0	0	0	1	0	0	0	10476	359	13	5	2452	5	NLRP14	11	7079046	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	3233837	7079046	127927470	108	7022										
WEE1	7465	broad.mit.edu	37	chr11	9608064	9608064	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtggtatgtgctgctggtgcTgaacctcttccgagaaatgg	14	8	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:9608064T>C	uc001mhs.2	+	9	1792	c.1539T>C	c.(1537-1539)GCT>GCC	p.A513A	WEE1_uc001mht.2_Silent_p.A299A	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1	513	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		CTGCTGGTGCTGAACCTCTTC	0.398													0	0	0	0.009096	0	3	94										C	9608064	T	C	9608064	2	2	25	1	0	0	0	0	0	0	0	1	17341	1567	55	5		5	WEE1	11	9608064	Silent	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	2529018	9608064	125398452	109	7023										
QSER1	79832	broad.mit.edu	37	chr11	32956871	32956871	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taaaaacttggaacatttatCttcattttcttctgatgaag	5	6	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:32956871C>G	uc001mty.2	+	4	3947	c.3680C>G	c.(3679-3681)TCT>TGT	p.S1227C	QSER1_uc001mtz.1_Missense_Mutation_p.S988C|QSER1_uc001mua.2_Missense_Mutation_p.S732C	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1227										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					GAACATTTATCTTCATTTTCT	0.363													0	0	0	0.139131	0	77	132										G	32956871	C	G	32956871	3	3	25	1	0	0	0	0	1	0	0	0	12882	913	32	1	3686	1	QSER1	11	32956871	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	23348807	32956871	102049645	110	7024										
OR5M8	219484	broad.mit.edu	37	chr11	56258184	56258184	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cgaatctttaaaatagcaggGaaaatgtaaaggtaggaaat	10	3	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:56258184G>A	uc001nix.1	-	1	663	c.663C>T	c.(661-663)TTC>TTT	p.F221F		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					AAATAGCAGGGAAAATGTAAA	0.408													0	0	0	0.0333	0	18	46										A	56258184	G	A	56258184	2	1	25	1	0	0	0	0	0	0	0	1	11176	1165	41	1		1	OR5M8	11	56258184	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	23301313	56258184	78748332	111	7025										
OR5M10	390167	broad.mit.edu	37	chr11	56344512	56344512	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgtgcctgccttcagcagaaCggatcctgaagatcgctgca	11	12	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:56344512C>A	uc001niz.1	-	1	686	c.686G>T	c.(685-687)CGT>CTT	p.R229L		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCAGCAGAACGGATCCTGAA	0.443													1	0	3.07281e-33	0.139131	3.41679e-33	61	49										A	56344512	C	A	56344512	3	1	25	1	0	0	0	0	1	0	0	0	11173	536	19	4	265	4	OR5M10	11	56344512	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	86328	56344512	78662004	112	7026										
PC	5091	broad.mit.edu	37	chr11	66619974	66619974	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	acatagggggcgatctttttGagatcgtgggtgcgcacacg	15	8	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:66619974G>C	uc001ojn.1	-	13	1810	c.1761C>G	c.(1759-1761)CTC>CTG	p.L587L	PC_uc001ojo.1_Silent_p.L587L|PC_uc001ojp.1_Silent_p.L587L|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	587	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CGATCTTTTTGAGATCGTGGG	0.612													0	0	0	0.139131	0	43	109										C	66619974	G	C	66619974	2	2	25	1	0	0	0	0	0	0	0	1	11497	1277	45	1		1	PC	11	66619974	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	10275462	66619974	68386542	113	7027										
SSH3	54961	broad.mit.edu	37	chr11	67075644	67075644	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgccctgggctctgcctgcaGatccgccaggctctggagct	13	15	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:67075644G>T	uc001okj.2	+	9	1064	c.886_splice	c.e9-1	p.I296_splice	SSH3_uc001okk.2_Splice_Site|SSH3_uc001okl.2_Splice_Site_p.I150_splice	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3						regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TCTGCCTGCAGATCCGCCAGG	0.647													1	0	1.15505e-17	0.11126	1.24261e-17	37	103										T	67075644	G	T	67075644	5	4	25	1	0	0	0	0	0	0	1	0	15185	956	33	3	919	3	SSH3	11	67075644	Splice_Site	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	455670	67075644	67930872	114	7028										
RNF121	55298	broad.mit.edu	37	chr11	71698134	71698134	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atggctgtcatgtttaccctCtttggtcttaacttattatt	6	8	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:71698134C>T	uc001ora.2	+	5	823	c.483C>T	c.(481-483)CTC>CTT	p.L161L	RNF121_uc001ord.2_Silent_p.L80L|RNF121_uc001orb.2_Silent_p.L129L|RNF121_uc009yst.2_Silent_p.L129L	NM_018320	NP_060790	Q9H920	RN121_HUMAN	ring finger protein 121	161	Helical; (Potential).					integral to membrane	zinc ion binding				0						TGTTTACCCTCTTTGGTCTTA	0.423													0	0	0	0.139131	0	56	94										T	71698134	C	T	71698134	2	4	25	1	0	0	0	0	0	0	0	1	13431	900	32	1		1	RNF121	11	71698134	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	4622490	71698134	63308382	115	7029										
C11orf30	56946	broad.mit.edu	37	chr11	76257009	76257009	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgagaagacagcagtgtctGacattttgaaaatgtctttg	10	6	2	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:76257009G>C	uc001oxl.2	+	20	3585	c.3442G>C	c.(3442-3444)GAC>CAC	p.D1148H	C11orf30_uc001oxm.2_Missense_Mutation_p.D1050H|C11orf30_uc010rsb.1_Missense_Mutation_p.D1163H|C11orf30_uc010rsc.1_Missense_Mutation_p.D1149H|C11orf30_uc001oxn.2_Missense_Mutation_p.D1149H|C11orf30_uc010rsd.1_Missense_Mutation_p.D1057H|C11orf30_uc010rse.1_Missense_Mutation_p.D395H|C11orf30_uc001oxp.2_Intron	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1148					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						AGCAGTGTCTGACATTTTGAA	0.438													0	0	0	0.083992	0	25	70										C	76257009	G	C	76257009	3	2	25	1	0	0	0	0	1	0	0	0	1636	1290	45	1	3516	1	C11orf30	11	76257009	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	4558875	76257009	58749507	116	7030										
PRSS23	11098	broad.mit.edu	37	chr11	86518961	86518961	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcttatgaaacgctctatgcCaatggcagccgcacagagac	9	12	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:86518961C>T	uc001pcb.2	+	2	492	c.276C>T	c.(274-276)GCC>GCT	p.A92A	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Silent_p.A60A	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	92					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGCTCTATGCCAATGGCAGCC	0.517													0	0	0	0.045705	0	17	34										T	86518961	C	T	86518961	2	4	25	1	0	0	0	0	0	0	0	1	12620	581	21	2		2	PRSS23	11	86518961	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	10261952	86518961	48487555	117	7031										
KDM4D	55693	broad.mit.edu	37	chr11	94731995	94731995	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	catgcacagcttcgggcccaGaacctgagcccctacctgag	10	16	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:94731995G>A	uc001pfe.2	+	3	2291	c.1459G>A	c.(1459-1461)GAA>AAA	p.E487K		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	487					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TTCGGGCCCAGAACCTGAGCC	0.622													0	0	0	0.062417	0	23	53										A	94731995	G	A	94731995	3	1	25	1	0	0	0	0	1	0	0	0	8131	943	33	1	1461	1	KDM4D	11	94731995	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	8213034	94731995	40274521	118	7032										
DDI1	414301	broad.mit.edu	37	chr11	103908030	103908030	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccccacgatctgtccctgctCaaggaacgcaaccctccctt	6	19	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:103908030C>G	uc001phr.2	+	1	723	c.480C>G	c.(478-480)CTC>CTG	p.L160L	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	160					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGTCCCTGCTCAAGGAACGCA	0.622													0	0	0	0.0918	0	22	112										G	103908030	C	G	103908030	2	3	25	1	0	0	0	0	0	0	0	1	4328	813	29	1		1	DDI1	11	103908030	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	9176035	103908030	31098486	119	7033										
GUCY1A2	2977	broad.mit.edu	37	chr11	106558469	106558469	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aatgaatgtgaaactttcttCtcgttttaataatctaagaa	5	5	3	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:106558469C>G	uc001pjg.1	-	8	2395	c.2005G>C	c.(2005-2007)GAA>CAA	p.E669Q	GUCY1A2_uc010rvo.1_Missense_Mutation_p.E690Q|GUCY1A2_uc009yxn.1_Missense_Mutation_p.E700Q	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	669					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AAACTTTCTTCTCGTTTTAAT	0.408													0	0	0	0.11126	0	41	57										G	106558469	C	G	106558469	3	3	25	1	0	0	0	0	1	0	0	0	6893	922	32	1	197	1	GUCY1A2	11	106558469	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2650439	106558469	28448047	120	7034										
ROBO4	54538	broad.mit.edu	37	chr11	124757704	124757704	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctccaaggagtggctgccccGgagcagtggggaactgttgg	17	10	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:124757704G>A	uc001qbg.2	-	13	2121	c.1981C>T	c.(1981-1983)CGG>TGG	p.R661W	ROBO4_uc010sas.1_Missense_Mutation_p.R516W|ROBO4_uc001qbh.2_Missense_Mutation_p.R551W|ROBO4_uc001qbi.2_Missense_Mutation_p.R219W|ROBO4_uc010sat.1_Missense_Mutation_p.R219W	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	661					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGGCTGCCCCGGAGCAGTGGG	0.577													0	0	0	0.045705	0	29	23										A	124757704	G	A	124757704	3	1	25	1	0	0	0	0	1	0	0	0	13516	1115	39	2	1066	2	ROBO4	11	124757704	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	18199235	124757704	10248812	121	7035										
C12orf60	144608	broad.mit.edu	37	chr12	14976569	14976569	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aagcgataaagactatggaaAtgaatatttctgtgtttaag	9	3	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:14976569A>G	uc001rcj.3	+	2	904	c.700A>G	c.(700-702)ATG>GTG	p.M234V		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	234										ovary(1)|central_nervous_system(1)	2						GACTATGGAAATGAATATTTC	0.358													0	0	0	0.0918	0	24	36										G	14976569	A	G	14976569	3	3	25	1	0	0	0	0	1	0	0	0	1703	101	4	5	702	5	C12orf60	12	14976569	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08		14976569	118875326	122	7036										
PDE3A	5139	broad.mit.edu	37	chr12	20523043	20523043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gagcatttggggtcccagctGattgctgggaccaaggaaga	15	8	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:20523043G>A	uc001reh.1	+	1	847	c.825G>A	c.(823-825)CTG>CTA	p.L275L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627													0	0	0	0.124865	0	44	39										A	20523043	G	A	20523043	2	1	25	1	0	0	0	0	0	0	0	1	11637	1277	45	1		1	PDE3A	12	20523043	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	5546474	20523043	113328852	123	7037										
COL2A1	1280	broad.mit.edu	37	chr12	48381056	48381056	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cacgggcaacactcacagcaGatcctttggctccaggaatt	9	13	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:48381056G>T	uc001rqu.2	-	20	1443	c.1262C>A	c.(1261-1263)TCT>TAT	p.S421Y	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.S352Y	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	421	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	ACTCACAGCAGATCCTTTGGC	0.557													1	0	1.99824e-07	0.0333	2.08938e-07	14	49										T	48381056	G	T	48381056	3	4	25	1	0	0	0	0	1	0	0	0	3687	942	33	3	3341	3	COL2A1	12	48381056	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	27858013	48381056	85470839	124	7038										
COL2A1	1280	broad.mit.edu	37	chr12	48390378	48390378	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggcgccaccagccttttcatCaaatcctccagccatctggg	8	16	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:48390378C>G	uc001rqu.2	-	8	743	c.562G>C	c.(562-564)GAT>CAT	p.D188H	COL2A1_uc001rqv.2_Missense_Mutation_p.D119H	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	188					axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCCTTTTCATCAAATCCTCCA	0.498													0	0	0	0.139131	0	118	413										G	48390378	C	G	48390378	3	3	25	1	0	0	0	0	1	0	0	0	3687	826	29	1	4089	1	COL2A1	12	48390378	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	9322	48390378	85461517	125	7039										
ZNF641	121274	broad.mit.edu	37	chr12	48739131	48739131	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gagaaggtcatgcttactcaGagagactactatcccacagt	9	10	2	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:48739131G>C	uc001rrn.1	-	4	610	c.445C>G	c.(445-447)CTG>GTG	p.L149V	ZNF641_uc001rro.1_Missense_Mutation_p.L135V|ZNF641_uc010sls.1_Intron	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	149	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.L149L(1)		ovary(1)|pancreas(1)	2						TGCTTACTCAGAGAGACTACT	0.502													0	0	0	0.146539	0	17	85										C	48739131	G	C	48739131	3	2	25	1	0	0	0	0	1	0	0	0	18054	933	33	1	883	1	ZNF641	12	48739131	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	348753	48739131	85112764	126	7040										
MLL2	8085	broad.mit.edu	37	chr12	49416552	49416552	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggtgcgcagccgccggtactGagatgacttggagtgcacaa	15	10	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:49416552G>A	uc001rta.3	-	51	16159	c.16159C>T	c.(16159-16161)CAG>TAG	p.Q5387*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5387					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CGCCGGTACTGAGATGACTTG	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.139131	0	27	25										A	49416552	G	A	49416552	4	1	25	1	0	0	0	0	0	1	0	0	9621	1299	45	1	470	1	MLL2	12	49416552	Nonsense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	677421	49416552	84435343	127	7041										
DIP2B	57609	broad.mit.edu	37	chr12	51065079	51065079	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cctggatcaaccgttcaattCagggatcgtccacttcttca	7	13	5	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:51065079C>T	uc001rwv.2	+	5	694	c.538C>T	c.(538-540)CAG>TAG	p.Q180*	DIP2B_uc001rwu.2_Nonsense_Mutation_p.Q180*|DIP2B_uc009zls.1_Nonsense_Mutation_p.Q62*	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	180	Ser-rich.					nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CCGTTCAATTCAGGGATCGTC	0.527													0	0	0	0.139131	0	82	71										T	51065079	C	T	51065079	4	4	25	1	0	0	0	0	0	1	0	0	4528	827	29	1	556	1	DIP2B	12	51065079	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	1648527	51065079	82786816	128	7042										
LETMD1	25875	broad.mit.edu	37	chr12	51451849	51451849	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggcctgaattctacgcataTtggtgaagataggtgtcgaa	12	6	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:51451849T>C	uc001rxm.2	+	8	1006	c.950T>C	c.(949-951)ATT>ACT	p.I317T	LETMD1_uc001rxl.2_Missense_Mutation_p.I261T|LETMD1_uc009zlv.2_RNA|LETMD1_uc001rxs.2_Intron|LETMD1_uc009zlw.2_Missense_Mutation_p.I330T|LETMD1_uc001rxn.2_Missense_Mutation_p.I160T|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Missense_Mutation_p.I200T|LETMD1_uc001rxq.2_Missense_Mutation_p.I193T|LETMD1_uc001rxr.2_RNA|LETMD1_uc001rxt.2_Missense_Mutation_p.I57T	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	317	Mitochondrial intermembrane (Potential).|LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						TCTACGCATATTGGTGAAGAT	0.408													0	0	0	0.049695	0	19	68										C	51451849	T	C	51451849	3	2	25	1	0	0	0	0	1	0	0	0	8736	1493	52	5	980	5	LETMD1	12	51451849	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	386770	51451849	82400046	129	7043										
KRT78	196374	broad.mit.edu	37	chr12	53241751	53241751	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	actcagcatccagagcccctCgttctccctggagctgctcc	8	18	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:53241751C>A	uc001sbc.1	-	2	603	c.539G>T	c.(538-540)CGA>CTA	p.R180L		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	180	Coil 1B.|Rod.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						CAGAGCCCCTCGTTCTCCCTG	0.607													1	0	3.6726e-16	0.0918	3.92271e-16	24	68										A	53241751	C	A	53241751	3	1	25	1	0	0	0	0	1	0	0	0	8491	884	31	3	1055	3	KRT78	12	53241751	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	1789902	53241751	80610144	130	7044										
GDF11	10220	broad.mit.edu	37	chr12	56142751	56142751	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggctgtcacctccctggggcCgggagccgaggggctggtga	19	12	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:56142751C>T	uc001shq.2	+	2	864	c.827C>T	c.(826-828)CCG>CTG	p.P276L	GDF11_uc010spv.1_Missense_Mutation_p.P276L	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	276					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						TCCCTGGGGCCGGGAGCCGAG	0.597													0	0	0	0.021553	0	5	23										T	56142751	C	T	56142751	3	4	25	1	0	0	0	0	1	0	0	0	6312	652	23	2	833	2	GDF11	12	56142751	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2901000	56142751	77709144	131	7045										
B4GALNT1	2583	broad.mit.edu	37	chr12	58021630	58021630	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aagccggagatctcgcgcacCgcgccccccacctgcaggga	12	18	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:58021630C>T	uc001spg.1	-	10	1587	c.1155G>A	c.(1153-1155)GCG>GCA	p.A385A	B4GALNT1_uc010sru.1_Silent_p.A330A	NM_001478	NP_001469	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	385	Lumenal (Potential).				lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity				0	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TCTCGCGCACCGCGCCCCCCA	0.711													0	0	0	0.009096	0	3	6										T	58021630	C	T	58021630	2	4	25	1	0	0	0	0	0	0	0	1	1266	639	23	2		2	B4GALNT1	12	58021630	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	1878879	58021630	75830265	132	7046										
IL26	55801	broad.mit.edu	37	chr12	68595841	68595841	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggtaatggatttcatctctCtagctgatgaagcacaggaa	10	7	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:68595841C>G	uc001stx.1	-	4	421	c.386G>C	c.(385-387)AGA>ACA	p.R129T		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	129					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTTCATCTCTCTAGCTGATGA	0.239													0	0	0	0.014758	0	5	13										G	68595841	C	G	68595841	3	3	25	1	0	0	0	0	1	0	0	0	7679	913	32	1	137	1	IL26	12	68595841	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	10574211	68595841	65256054	133	7047										
RAP1B	5908	broad.mit.edu	37	chr12	69042512	69042512	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	acaagcttgcatcatgcgtgAgtataagctagtcgttcttg	10	8	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:69042512A>G	uc001sub.2	+	2	171	c.8A>G	c.(7-9)GAG>GGG	p.E3G	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Missense_Mutation_p.E3G|RAP1B_uc010stf.1_Missense_Mutation_p.E3G|RAP1B_uc010stg.1_Missense_Mutation_p.E3G|RAP1B_uc010sth.1_Missense_Mutation_p.E3G|RAP1B_uc010sti.1_Missense_Mutation_p.E3G	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	3					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		ATCATGCGTGAGTATAAGCTA	0.373													0	0	0	0.139131	0	520	27										G	69042512	A	G	69042512	3	3	25	1	0	0	0	0	1	0	0	0	13036	304	11	5	10	5	RAP1B	12	69042512	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	446671	69042512	64809383	134	7048										
NUP107	57122	broad.mit.edu	37	chr12	69109478	69109478	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaagatgaagttagattactCaaatatctctttactctaat	5	6	3	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:69109478C>G	uc001suf.2	+	12	1156	c.1041C>G	c.(1039-1041)CTC>CTG	p.L347L	NUP107_uc001sug.2_Silent_p.L194L|NUP107_uc010stj.1_Silent_p.L318L	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	347					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TTAGATTACTCAAATATCTCT	0.333													0	0	0	0.0333	0	17	894										G	69109478	C	G	69109478	2	3	25	1	0	0	0	0	0	0	0	1	10753	813	29	1		1	NUP107	12	69109478	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	66966	69109478	64742417	135	7049										
PTPRB	5787	broad.mit.edu	37	chr12	70932750	70932750	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttccctctattctccggcaaGagtgcaatgtcacatgactg	8	12	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:70932750G>C	uc001swb.3	-	25	5199	c.5169C>G	c.(5167-5169)CTC>CTG	p.L1723L	PTPRB_uc010sto.1_Silent_p.L1633L|PTPRB_uc010stp.1_Silent_p.L1633L|PTPRB_uc001swc.3_Silent_p.L1941L|PTPRB_uc001swa.3_Silent_p.L1853L	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1723	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTCCGGCAAGAGTGCAATGT	0.368													0	0	0	0.09319	0	13	23										C	70932750	G	C	70932750	2	2	25	1	0	0	0	0	0	0	0	1	12796	929	33	1		1	PTPRB	12	70932750	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1823272	70932750	62919145	136	7050										
TSPAN8	7103	broad.mit.edu	37	chr12	71526475	71526475	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atgtgatttagttctcacctCtttgtaaacttgttttccat	5	8	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:71526475C>G	uc009zrt.1	-	6	736	c.574G>C	c.(574-576)GAG>CAG	p.E192Q	TSPAN8_uc001swk.1_Missense_Mutation_p.E192Q|TSPAN8_uc001swj.1_Missense_Mutation_p.E192Q	NM_004616	NP_004607	P19075	TSN8_HUMAN	transmembrane 4 superfamily member 3	192	Extracellular (Potential).				protein glycosylation	integral to membrane|lysosome	signal transducer activity			skin(2)|lung(1)|central_nervous_system(1)	4			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			GTTCTCACCTCTTTGTAAACT	0.343													0	0	0	0.054565	0	34	120										G	71526475	C	G	71526475	3	3	25	1	0	0	0	0	1	0	0	0	16650	922	32	1	151	1	TSPAN8	12	71526475	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	593725	71526475	62325420	137	7051										
ZFC3H1	196441	broad.mit.edu	37	chr12	72057372	72057372	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gccactggaggccggggccgGagtatctgcggtcgccatcc	16	14	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:72057372G>C	uc001swo.2	-	1	378	c.19C>G	c.(19-21)CCG>GCG	p.P7A	ZFC3H1_uc010sts.1_Missense_Mutation_p.P7A|ZFC3H1_uc001swp.2_Missense_Mutation_p.P7A|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	7					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCCGGGGCCGGAGTATCTGCG	0.602											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	98	96										C	72057372	G	C	72057372	3	2	25	1	0	0	0	0	1	0	0	0	17630	1174	41	1	6090	1	ZFC3H1	12	72057372	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	530897	72057372	61794523	138	7052										
C12orf74	338809	broad.mit.edu	37	chr12	93100450	93100450	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtccagaggtgccaccccaaGactgtggagcctctcctcgg	12	15	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:93100450G>C	uc001tch.1	+	2	273	c.43G>C	c.(43-45)GAC>CAC	p.D15H	C12orf74_uc001tci.2_Missense_Mutation_p.D15H	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	15											0						GCCACCCCAAGACTGTGGAGC	0.557													0	0	0	0.0333	0	17	55										C	93100450	G	C	93100450	3	2	25	1	0	0	0	0	1	0	0	0	1714	942	33	1	45	1	C12orf74	12	93100450	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	21043078	93100450	40751445	139	7053										
C12orf74	338809	broad.mit.edu	37	chr12	93100519	93100519	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aggggagtctcctccagtttGaccggcaagccccaggccgc	13	15	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:93100519G>C	uc001tch.1	+	2	342	c.112G>C	c.(112-114)GAC>CAC	p.D38H	C12orf74_uc001tci.2_Missense_Mutation_p.D38H	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	38											0						CCTCCAGTTTGACCGGCAAGC	0.622													0	0	0	0.116897	0	23	70										C	93100519	G	C	93100519	3	2	25	1	0	0	0	0	1	0	0	0	1714	1290	45	1	114	1	C12orf74	12	93100519	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	69	93100519	40751376	140	7054										
ACACB	32	broad.mit.edu	37	chr12	109702924	109702924	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctcgtccacaggacatcctgGagtggaagaccgcacgcacc	11	15	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:109702924G>C	uc001tob.2	+	51	7071	c.6952G>C	c.(6952-6954)GAG>CAG	p.E2318Q	ACACB_uc001toc.2_Missense_Mutation_p.E2318Q|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.E984Q	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2318					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGACATCCTGGAGTGGAAGAC	0.647													0	0	0	0.134883	0	30	150										C	109702924	G	C	109702924	3	2	25	1	0	0	0	0	1	0	0	0	107	1175	41	1	7150	1	ACACB	12	109702924	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	16602405	109702924	24148971	141	7055										
ATP2A2	488	broad.mit.edu	37	chr12	110720594	110720594	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttattactggcagcatgtatAtcttttgtaagtataaaaaa	6	4	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:110720594A>G	uc001tqk.3	+	3	776	c.213A>G	c.(211-213)ATA>ATG	p.I71M	ATP2A2_uc001tql.3_Missense_Mutation_p.I71M|ATP2A2_uc010sxy.1_Missense_Mutation_p.I71M	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	71	Lumenal (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						CAGCATGTATATCTTTTGTAA	0.328													0	0	0	0.055883	0	19	59										G	110720594	A	G	110720594	3	3	25	1	0	0	0	0	1	0	0	0	1137	439	16	5	223	5	ATP2A2	12	110720594	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	1017670	110720594	23131301	142	7056										
CCDC63	160762	broad.mit.edu	37	chr12	111291361	111291361	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tttaagttccgaaaccagcaGaagattgcgagtcagtagta	10	7	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:111291361G>T	uc001trv.1	+	3	357	c.162G>T	c.(160-162)CAG>CAT	p.Q54H	CCDC63_uc009zvt.1_Intron|CCDC63_uc010sye.1_Missense_Mutation_p.Q14H|CCDC63_uc001trw.1_Intron	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	54	Potential.			RQQFRKMVESRKSFKFRNQQKIASQY -> VGSAVAAAVGQ AARAATDKQSGPRHC (in Ref. 2; AAH64580).						skin(6)|ovary(1)|pancreas(1)	8						GAAACCAGCAGAAGATTGCGA	0.512													1	0	7.03913e-09	0.09319	7.41223e-09	12	39										T	111291361	G	T	111291361	3	4	25	1	0	0	0	0	1	0	0	0	2834	933	33	3	168	3	CCDC63	12	111291361	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	570767	111291361	22560534	143	7057										
CUX2	23316	broad.mit.edu	37	chr12	111655742	111655742	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taaaaagcttccaagccgagGtaagacccagggcccacagc	10	13	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:111655742G>T	uc001tsa.1	+	3	375	c.222_splice	c.e3+1	p.E74_splice	CUX2_uc001tsb.1_Splice_Site_p.E129_splice	NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CCAAGCCGAGGTAAGACCCAG	0.562													1	0	8.81991e-31	0.139131	9.73457e-31	53	66										T	111655742	G	T	111655742	5	4	25	1	0	0	0	0	0	0	1	0	4065	1275	44	4	233	4	CUX2	12	111655742	Splice_Site	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	364381	111655742	22196153	144	7058										
NAA25	80018	broad.mit.edu	37	chr12	112477050	112477050	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taccatgatgatgctggtttCttttttcttctttttctttt	5	7	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:112477050C>G	uc001ttm.2	-	22	2652	c.2632G>C	c.(2632-2634)GAA>CAA	p.E878Q	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.E850Q|NAA25_uc009zwa.1_Missense_Mutation_p.E856Q	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	878						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ATGCTGGTTTCTTTTTTCTTC	0.348													0	0	0	0.146539	0	17	38										G	112477050	C	G	112477050	3	3	25	1	0	0	0	0	1	0	0	0	10121	922	32	1	298	1	NAA25	12	112477050	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	821308	112477050	21374845	145	7059										
C12orf51	283450	broad.mit.edu	37	chr12	112694164	112694164	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aagagcatctgctatcaaatCtaaggtacaggcagcgagct	10	9	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:112694164C>G	uc009zwc.2	-	14	2009	c.1991G>C	c.(1990-1992)AGA>ACA	p.R664T	C12orf51_uc010syk.1_Missense_Mutation_p.R487T|C12orf51_uc001tts.2_Missense_Mutation_p.R487T|C12orf51_uc001ttt.3_Missense_Mutation_p.R485T	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTATCAAATCTAAGGTACAG	0.443													0	0	0	0.134883	0	26	101										G	112694164	C	G	112694164	3	3	25	1	0	0	0	0	1	0	0	0	1696	913	32	1	10223	1	C12orf51	12	112694164	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	217114	112694164	21157731	146	7060										
VSIG10	54621	broad.mit.edu	37	chr12	118517226	118517226	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	acacttgaacttcttgccatCcgacagctgggactcgctca	8	14	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:118517226C>G	uc001tws.2	-	4	1184	c.850G>C	c.(850-852)GAT>CAT	p.D284H		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	284	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane					0						TTCTTGCCATCCGACAGCTGG	0.537													0	0	0	0.080935	0	12	72										G	118517226	C	G	118517226	3	3	25	1	0	0	0	0	1	0	0	0	17220	855	30	1	796	1	VSIG10	12	118517226	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	5823062	118517226	15334669	147	7061										
COQ5	84274	broad.mit.edu	37	chr12	120966898	120966898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cccgcatcgcccgcgaccacCcacggccgcaatagctccat	8	21	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:120966898C>T	uc001tyn.2	-	1	67	c.47G>A	c.(46-48)GGG>GAG	p.G16E	COQ5_uc001tyo.2_5'UTR|COQ5_uc010szj.1_Missense_Mutation_p.G16E	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	16					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGCGACCACCCACGGCCGCA	0.647													0	0	0	0.116897	0	27	25										T	120966898	C	T	120966898	3	4	25	1	0	0	0	0	1	0	0	0	3748	623	22	2	964	2	COQ5	12	120966898	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2449672	120966898	12884997	148	7062										
DNAH10	196385	broad.mit.edu	37	chr12	124298176	124298176	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aggagctctataatctccatGaagagatggaggtactcaat	10	7	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:124298176G>A	uc001uft.3	+	19	3281	c.3256G>A	c.(3256-3258)GAA>AAA	p.E1086K	DNAH10_uc010tav.1_Missense_Mutation_p.E628K|DNAH10_uc010taw.1_Missense_Mutation_p.E571K	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1086	Stem (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAATCTCCATGAAGAGATGGA	0.423													0	0	0	0.099896	0	26	66										A	124298176	G	A	124298176	3	1	25	1	0	0	0	0	1	0	0	0	4598	1291	45	1	3330	1	DNAH10	12	124298176	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	3331278	124298176	9553719	149	7063										
NCOR2	9612	broad.mit.edu	37	chr12	124957593	124957593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagctcctccttggacagccGtggcggcaccagctccagct	11	17	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:124957593G>A	uc010tba.1	-	4	613	c.496C>T	c.(496-498)CGG>TGG	p.R166W	NCOR2_uc010tay.1_Missense_Mutation_p.R166W|NCOR2_uc010taz.1_Missense_Mutation_p.R166W|NCOR2_uc010tbb.1_Missense_Mutation_p.R166W|NCOR2_uc010tbc.1_Missense_Mutation_p.R166W|NCOR2_uc001ugj.1_Missense_Mutation_p.R166W|NCOR2_uc001ugk.1_Missense_Mutation_p.R166W	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	166					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTGGACAGCCGTGGCGGCACC	0.602													0	0	0	0.0918	0	26	88										A	124957593	G	A	124957593	3	1	25	1	0	0	0	0	1	0	0	0	10236	1144	40	2	7248	2	NCOR2	12	124957593	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	659417	124957593	8894302	150	7064										
TMEM132D	121256	broad.mit.edu	37	chr12	129559559	129559559	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atcgtaaatatccaagggcgTgactgagccatcactgaact	9	10	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:129559559T>G	uc009zyl.1	-	9	2489	c.2161A>C	c.(2161-2163)ACG>CCG	p.T721P	TMEM132D_uc001uia.2_Missense_Mutation_p.T259P	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	721	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCCAAGGGCGTGACTGAGCCA	0.473													0	0	0	0.059317	0	31	100										G	129559559	T	G	129559559	3	3	25	1	0	0	0	0	1	0	0	0	16044	1696	59	5	1142	5	TMEM132D	12	129559559	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	4601966	129559559	4292336	151	7065										
PSPC1	55269	broad.mit.edu	37	chr13	20315736	20315736	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgcttccgtttttgcaactCttggtttctgagttcttcca	7	10	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:20315736C>G	uc001uml.2	-	5	1207	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q	PSPC1_uc001umj.1_RNA|PSPC1_uc001umk.1_RNA	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	341	Sufficient for perinucleolar caps localization and interaction with NONO.|Potential.|Sufficient for paraspeckles localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		TTTTGCAACTCTTGGTTTCTG	0.328													0	0	0	0.108266	0	21	91										G	20315736	C	G	20315736	3	3	25	1	0	0	0	0	1	0	0	0	12716	922	32	1	570	1	PSPC1	13	20315736	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		20315736	94854142	152	7066										
FRY	10129	broad.mit.edu	37	chr13	32802752	32802752	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggacacagctgctgaaacagAtgagaaggcaaacaagctca	11	9	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:32802752A>T	uc001utx.2	+	40	5862	c.5366A>T	c.(5365-5367)GAT>GTT	p.D1789V	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1789					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCTGAAACAGATGAGAAGGCA	0.512													0	0	0	0.139131	0	50	68										T	32802752	A	T	32802752	3	4	25	1	0	0	0	0	1	0	0	0	6063	333	12	5	5524	5	FRY	13	32802752	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	12487016	32802752	82367126	153	7067										
LECT1	11061	broad.mit.edu	37	chr13	53282807	53282807	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggtagttggaacaatttttCttaccacttctcttctttcc	5	10	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:53282807C>T	uc001vhf.2	-	6	764	c.653G>A	c.(652-654)AGA>AAA	p.R218K	LECT1_uc001vhg.2_Missense_Mutation_p.R218K|LECT1_uc001vhh.2_Missense_Mutation_p.R207K	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	218					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		AACAATTTTTCTTACCACTTC	0.393													0	0	0	0.069456	0	33	111										T	53282807	C	T	53282807	3	4	25	1	0	0	0	0	1	0	0	0	8712	913	32	1	359	1	LECT1	13	53282807	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	20480055	53282807	61887071	154	7068										
PCDH9	5101	broad.mit.edu	37	chr13	67801771	67801771	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gagctgaattacagaggtacCtacgggagcattctctggaa	12	8	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:67801771C>G	uc001vik.2	-	2	1494	c.802G>C	c.(802-804)GGT>CGT	p.G268R	PCDH9_uc001vil.2_Missense_Mutation_p.G268R|PCDH9_uc010thl.1_Missense_Mutation_p.G268R|PCDH9_uc001vin.3_Missense_Mutation_p.G268R	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	268	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACAGAGGTACCTACGGGAGCA	0.483													0	0	0	0.139131	0	60	55										G	67801771	C	G	67801771	3	3	25	1	0	0	0	0	1	0	0	0	11518	681	24	4	2927	4	PCDH9	13	67801771	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	14518964	67801771	47368107	155	7069										
KLF5	688	broad.mit.edu	37	chr13	73636411	73636412	+	Frame_Shift_Ins	INS	-	-	G													0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctttctgtccctacccagcaINSgggccacctgtaccagctac							TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:73636411_73636412insG	uc001vje.2	+	2	998_999	c.674_675insG	c.(673-675)CAGfs	p.Q225fs	KLF5_uc001vjd.2_Frame_Shift_Ins_p.Q134fs	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	225					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CCTACCCAGCAGGGCCACCTGT	0.455																		27	83	---	---								G	73636412	-	G	73636411	7	5	25	1	0	1	1	0	0	0	0	0	8349	188	7	0	680	0	KLF5	13	73636411	Frame_Shift_Ins	INS	-	TCGA-C4-A0F6-01A-11D-A10S-08	5834640	73636411	41533467	156	7070										
MYH7	4625	broad.mit.edu	37	chr14	23885425	23885425	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cttggcctgttccatctcctCgtccttctctgccagcttcc	6	18	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:23885425C>T	uc001wjx.2	-	34	4847	c.4741G>A	c.(4741-4743)GAG>AAG	p.E1581K		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1581	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCATCTCCTCGTCCTTCTCT	0.647													0	0	0	0.139131	0	51	368										T	23885425	C	T	23885425	3	4	25	1	0	0	0	0	1	0	0	0	10039	893	31	1	1094	1	MYH7	14	23885425	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		23885425	83464115	157	7071										
NIN	51199	broad.mit.edu	37	chr14	51225101	51225101	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaccagagaagttgttttctCtctcttaagagtctctttca	7	9	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:51225101C>G	uc001wym.2	-	18	2838	c.2647G>C	c.(2647-2649)GAG>CAG	p.E883Q	NIN_uc001wyi.2_Missense_Mutation_p.E883Q|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.E889Q|NIN_uc001wyo.2_Missense_Mutation_p.E883Q	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	883	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GTTGTTTTCTCTCTCTTAAGA	0.502			T	PDGFRB	MPD								0	0	0	0.139131	0	94	36										G	51225101	C	G	51225101	3	3	25	1	0	0	0	0	1	0	0	0	10417	922	32	1	3958	1	NIN	14	51225101	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	27339676	51225101	56124439	158	7072										
DHRS7	51635	broad.mit.edu	37	chr14	60620715	60620715	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aacagctttggtagccgcttCatgggaaccagtgtcggtca	12	10	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:60620715C>T	uc001xes.2	-	3	539	c.355G>A	c.(355-357)GAA>AAA	p.E119K	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Missense_Mutation_p.E69K|DHRS7_uc001xeu.2_Missense_Mutation_p.E119K	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	119							binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		GTAGCCGCTTCATGGGAACCA	0.388													0	0	0	0.076483	0	20	97										T	60620715	C	T	60620715	3	4	25	1	0	0	0	0	1	0	0	0	4495	835	29	1	684	1	DHRS7	14	60620715	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	9395614	60620715	46728825	159	7073										
KCNH5	27133	broad.mit.edu	37	chr14	63246455	63246455	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agagaacatacccgtttcctCagattgcaagtaagagtgag	10	8	1	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:63246455C>G	uc001xfx.2	-	10	2061	c.2010G>C	c.(2008-2010)CTG>CTC	p.L670L	KCNH5_uc001xfy.2_Intron|KCNH5_uc001xfz.1_Silent_p.L612L	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	670	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CCCGTTTCCTCAGATTGCAAG	0.393													0	0	0	0.139131	0	93	84										G	63246455	C	G	63246455	2	3	25	1	0	0	0	0	0	0	0	1	8035	813	29	1		1	KCNH5	14	63246455	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2625740	63246455	44103085	160	7074										
C14orf4	64207	broad.mit.edu	37	chr14	77492242	77492242	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtgcgctgtgcccagagtatCtgccaccgacatgagagcgg	14	12	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:77492242C>G	uc001xsy.2	-	1	2793	c.1894G>C	c.(1894-1896)GAT>CAT	p.D632H		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	632						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		CCCAGAGTATCTGCCACCGAC	0.632													0	0	0	0.080935	0	11	31										G	77492242	C	G	77492242	3	3	25	1	0	0	0	0	1	0	0	0	1773	913	32	1	500	1	C14orf4	14	77492242	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	14245787	77492242	29857298	161	7075										
SERPINA4	5267	broad.mit.edu	37	chr14	95033347	95033347	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atttcctcaaggaccactccCaaagacttctatgttgatga	6	11	2	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:95033347C>G	uc001ydk.2	+	3	756	c.690C>G	c.(688-690)CCC>CCG	p.P230P	SERPINA4_uc010avd.2_Silent_p.P267P|SERPINA4_uc001ydl.2_Silent_p.P230P	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	230					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		GGACCACTCCCAAAGACTTCT	0.507													0	0	0	0.038395	0	19	121										G	95033347	C	G	95033347	2	3	25	1	0	0	0	0	0	0	0	1	14091	581	21	4		4	SERPINA4	14	95033347	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	17541105	95033347	12316193	162	7076										
EVL	51466	broad.mit.edu	37	chr14	100595958	100595958	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctcaaagtccgatgccaaccGggcaagcagcgggggtggcg	16	12	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:100595958G>A	uc001ygt.2	+	7	1009	c.770G>A	c.(769-771)CGG>CAG	p.R257Q	EVL_uc001ygv.2_Missense_Mutation_p.R263Q|EVL_uc001ygu.2_Missense_Mutation_p.R259Q|EVL_uc010avu.2_Missense_Mutation_p.R116Q	NM_016337	NP_057421	Q9UI08	EVL_HUMAN	Enah/Vasp-like	257	EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			large_intestine(2)|ovary(1)	3		Melanoma(154;0.152)				GATGCCAACCGGGCAAGCAGC	0.587													0	0	0	0.131918	0	45	22										A	100595958	G	A	100595958	3	1	25	1	0	0	0	0	1	0	0	0	5291	1116	39	2	802	2	EVL	14	100595958	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	5562611	100595958	6753582	163	7077										
OCA2	4948	broad.mit.edu	37	chr15	28211933	28211933	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agaacaaggcaaatcccaatGaacatgtgtgcagtgaatcc	9	9	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:28211933G>A	uc001zbh.3	-	15	1649	c.1539C>T	c.(1537-1539)TTC>TTT	p.F513F	OCA2_uc010ayv.2_Silent_p.F489F	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	513	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AAATCCCAATGAACATGTGTG	0.398									Oculocutaneous_Albinism				0	0	0	0.062417	0	22	19										A	28211933	G	A	28211933	2	1	25	1	0	0	0	0	0	0	0	1	10815	1281	45	1		1	OCA2	15	28211933	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		28211933	74319459	164	7078										
TJP1	7082	broad.mit.edu	37	chr15	30011184	30011184	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tatctgtatgtgggctgctcGaggtctctgctggcttgttt	13	8	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:30011184G>A	uc001zcr.2	-	21	3637	c.3162C>T	c.(3160-3162)CTC>CTT	p.L1054L	TJP1_uc010azl.2_Silent_p.L1042L|TJP1_uc001zcq.2_Silent_p.L978L|TJP1_uc001zcs.2_Silent_p.L974L	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1054					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TGGGCTGCTCGAGGTCTCTGC	0.517													0	0	0	0.139131	0	124	422										A	30011184	G	A	30011184	2	1	25	1	0	0	0	0	0	0	0	1	15926	1045	37	1		1	TJP1	15	30011184	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1799251	30011184	72520208	165	7079										
OTUD7A	161725	broad.mit.edu	37	chr15	31776455	31776455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgtacttccaggcgtcgcccCgcggcccaccgcccttctcc	9	21	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:31776455C>T	uc001zfq.2	-	11	1916	c.1823G>A	c.(1822-1824)CGG>CAG	p.R608Q	OTUD7A_uc001zfr.2_Missense_Mutation_p.R615Q	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	608						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGCGTCGCCCCGCGGCCCACC	0.697													0	0	0	0.047766	0	8	14										T	31776455	C	T	31776455	3	4	25	1	0	0	0	0	1	0	0	0	11318	652	23	2	961	2	OTUD7A	15	31776455	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	1765271	31776455	70754937	166	7080										
UNC13C	440279	broad.mit.edu	37	chr15	54919034	54919034	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taatccacacagcattctcgGaaaggaaaatcgaccagggg	10	10	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:54919034G>A	uc002ack.2	+	31	6368	c.6368G>A	c.(6367-6369)GGA>GAA	p.G2123E	UNC13C_uc002acm.2_Missense_Mutation_p.G44E	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2123	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGCATTCTCGGAAAGGAAAAT	0.284													0	0	0	0.038147	0	6	17										A	54919034	G	A	54919034	3	1	25	1	0	0	0	0	1	0	0	0	16983	1174	41	1	6490	1	UNC13C	15	54919034	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	23142579	54919034	47612358	167	7081										
SLTM	79811	broad.mit.edu	37	chr15	59179725	59179725	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttttcccctcactttgaccaAcaaagcgatcccgcctattg	5	15	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:59179725A>T	uc002afp.2	-	18	2478	c.2390T>A	c.(2389-2391)GTT>GAT	p.V797D	SLTM_uc002afn.2_Missense_Mutation_p.V339D|SLTM_uc002afo.2_Missense_Mutation_p.V779D|SLTM_uc002afq.2_Missense_Mutation_p.V366D|SLTM_uc010bgd.2_Missense_Mutation_p.V366D	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	797	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						ACTTTGACCAACAAAGCGATC	0.403													0	0	0	0.092188	0	41	101										T	59179725	A	T	59179725	3	4	25	1	0	0	0	0	1	0	0	0	14754	43	2	5	730	5	SLTM	15	59179725	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	4260691	59179725	43351667	168	7082										
CLN6	54982	broad.mit.edu	37	chr15	68504196	68504196	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agggtgcggggggaccgctcGatgagctggggttcagagtg	21	7	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:68504196G>A	uc002arf.2	-	4	461	c.303C>T	c.(301-303)ATC>ATT	p.I101I	CLN6_uc010ujy.1_Intron|CLN6_uc010ujz.1_Silent_p.I133I	NM_017882	NP_060352	Q9NWW5	CLN6_HUMAN	CLN6 protein	101	Helical; (Potential).				cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity				0						GGGACCGCTCGATGAGCTGGG	0.612													0	0	0	0.055883	0	22	72										A	68504196	G	A	68504196	2	1	25	1	0	0	0	0	0	0	0	1	3545	1048	37	1		1	CLN6	15	68504196	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	9324471	68504196	34027196	169	7083										
TBC1D21	161514	broad.mit.edu	37	chr15	74180837	74180837	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccgcctgcgtggtttatgctGagctcatccagaaggatgta	12	10	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:74180837G>C	uc002avz.2	+	10	1044	c.961G>C	c.(961-963)GAG>CAG	p.E321Q	TBC1D21_uc010ulc.1_Missense_Mutation_p.E285Q	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	321						intracellular	Rab GTPase activator activity			ovary(2)	2						GGTTTATGCTGAGCTCATCCA	0.383													0	0	0	0.047766	0	8	52										C	74180837	G	C	74180837	3	2	25	1	0	0	0	0	1	0	0	0	15607	1291	45	1	999	1	TBC1D21	15	74180837	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	5676641	74180837	28350555	170	7084										
ZNF710	374655	broad.mit.edu	37	chr15	90622959	90622959	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagcaggagatggaggacttCgaggagaacgcctacagcta	14	9	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:90622959C>T	uc002bov.1	+	5	2016	c.1893C>T	c.(1891-1893)TTC>TTT	p.F631F		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			TGGAGGACTTCGAGGAGAACG	0.582													0	0	0	0.117977	0	37	130										T	90622959	C	T	90622959	2	4	25	1	0	0	0	0	0	0	0	1	18112	883	31	1		1	ZNF710	15	90622959	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	16442122	90622959	11908433	171	7085										
FURIN	5045	broad.mit.edu	37	chr15	91421501	91421501	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtggatgggccagcccgcctCgccgaggaggccttcttccg	15	15	1	0	rs146865309		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:91421501C>T	uc002bpu.1	+	8	1023	c.807C>T	c.(805-807)CTC>CTT	p.L269L		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	269					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CAGCCCGCCTCGCCGAGGAGG	0.642													0	0	0	0.038395	0	17	28										T	91421501	C	T	91421501	2	4	25	1	0	0	0	0	0	0	0	1	6099	871	31	1		1	FURIN	15	91421501	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	798542	91421501	11109891	172	7086										
AXIN1	8312	broad.mit.edu	37	chr16	347183	347183	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gctggcgctcttccccgactCagccttcttggcatttcttt	8	15	4	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:347183C>A	uc002cgp.1	-	7	2005	c.1828G>T	c.(1828-1830)GAG>TAG	p.E610*	AXIN1_uc002cgq.1_Nonsense_Mutation_p.E610*	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	610	Interaction with RNF111.|Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				TTCCCCGACTCAGCCTTCTTG	0.612													1	0	3.33393e-45	0.139131	3.72101e-45	88	308										A	347183	C	A	347183	4	1	25	1	0	0	0	0	0	1	0	0	1236	835	29	3	780	3	AXIN1	16	347183	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		347183	90007570	173	7087										
STUB1	10273	broad.mit.edu	37	chr16	731323	731323	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agctggagatggagagctatGatgaggccatcgccaatctg	14	8	1	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:731323G>C	uc002cit.2	+	2	742	c.331G>C	c.(331-333)GAT>CAT	p.D111H	STUB1_uc002ciu.2_Missense_Mutation_p.D39H|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	111	TPR 3.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				GGAGAGCTATGATGAGGCCAT	0.667													0	0	0	0.038395	0	18	44										C	731323	G	C	731323	3	2	25	1	0	0	0	0	1	0	0	0	15334	1290	45	1	337	1	STUB1	16	731323	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	384140	731323	89623430	174	7088										
STUB1	10273	broad.mit.edu	37	chr16	732373	732373	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgtcactgcagcgtgtgggtCattttgaccccgtgacccgg	13	12	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:732373C>T	uc002cit.2	+	7	1207	c.796C>T	c.(796-798)CAT>TAT	p.H266Y	STUB1_uc002ciu.2_Missense_Mutation_p.H194Y|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	266	U-box.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				GCGTGTGGGTCATTTTGACCC	0.612													0	0	0	0.139131	0	64	73										T	732373	C	T	732373	3	4	25	1	0	0	0	0	1	0	0	0	15334	826	29	1	822	1	STUB1	16	732373	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	1050	732373	89622380	175	7089										
XYLT1	64131	broad.mit.edu	37	chr16	17353054	17353054	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttttcctggcatgaggcggtCtggacacatccttcccgtgg	12	12	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:17353054C>G	uc002dfa.2	-	3	789	c.704G>C	c.(703-705)AGA>ACA	p.R235T		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	235	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						ATGAGGCGGTCTGGACACATC	0.612													0	0	0	0.139131	0	47	187										G	17353054	C	G	17353054	3	3	25	1	0	0	0	0	1	0	0	0	17460	913	32	1	2215	1	XYLT1	16	17353054	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	16620681	17353054	73001699	176	7090										
TNRC6A	27327	broad.mit.edu	37	chr16	24815594	24815594	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aggccctggttctcggcctcAgatttccaaagagtcttcca	9	13	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:24815594A>G	uc002dmm.2	+	12	3905	c.3791A>G	c.(3790-3792)CAG>CGG	p.Q1264R	TNRC6A_uc010bxs.2_Missense_Mutation_p.Q1011R|TNRC6A_uc002dmn.2_Missense_Mutation_p.Q1011R|TNRC6A_uc002dmo.2_Missense_Mutation_p.Q952R|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_5'Flank	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1264	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TCTCGGCCTCAGATTTCCAAA	0.393													0	0	0	0.09836	0	40	42										G	24815594	A	G	24815594	3	3	25	1	0	0	0	0	1	0	0	0	16337	188	7	5	3837	5	TNRC6A	16	24815594	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	7462540	24815594	65539159	177	7091										
ARHGAP17	55114	broad.mit.edu	37	chr16	24988548	24988548	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	atactcacgtgtctcctctcGgcatcggtgccatgctggcc	10	15	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:24988548G>A	uc002dnb.2	-	3	279	c.186C>T	c.(184-186)GCC>GCT	p.A62A	ARHGAP17_uc002dnc.2_Silent_p.A62A|ARHGAP17_uc010vcf.1_Intron|ARHGAP17_uc002dng.1_Silent_p.A62A	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	62	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		GTCTCCTCTCGGCATCGGTGC	0.547													0	0	0	0.058154	0	10	53										A	24988548	G	A	24988548	2	1	25	1	0	0	0	0	0	0	0	1	867	1103	39	2		2	ARHGAP17	16	24988548	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	172954	24988548	65366205	178	7092										
XPO6	23214	broad.mit.edu	37	chr16	28137114	28137114	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agcagggagctcaagtctctCagggagcagtgcagccgccg	15	12	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:28137114C>G	uc002dpa.1	-	13	2163	c.1662G>C	c.(1660-1662)CTG>CTC	p.L554L	XPO6_uc002dpb.1_Silent_p.L540L|XPO6_uc010vcp.1_Silent_p.L554L	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	554					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						TCAAGTCTCTCAGGGAGCAGT	0.592													0	0	0	0.139131	0	46	118										G	28137114	C	G	28137114	2	3	25	1	0	0	0	0	0	0	0	1	17445	813	29	1		1	XPO6	16	28137114	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	3148566	28137114	62217639	179	7093										
TEPP	374739	broad.mit.edu	37	chr16	58019836	58019836	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cactttccgaagcttcggctCcagctacaggtaggggaacg	12	12	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:58019836C>A	uc002emw.3	+	7	813	c.776C>A	c.(775-777)TCC>TAC	p.S259Y	TEPP_uc002emv.3_Missense_Mutation_p.S286Y	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	259						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						AGCTTCGGCTCCAGCTACAGG	0.652													1	0	3.27435e-08	0.11911	3.43576e-08	11	33										A	58019836	C	A	58019836	3	1	25	1	0	0	0	0	1	0	0	0	15757	855	30	3	883	3	TEPP	16	58019836	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	29882722	58019836	32334917	180	7094										
ACD	65057	broad.mit.edu	37	chr16	67691914	67691914	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagagcagggctcctgggctCccctggtagctccggtcctg	14	15	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:67691914C>T	uc002etq.3	-	10	1776	c.1439G>A	c.(1438-1440)GGA>GAA	p.G480E	ACD_uc002etp.3_Missense_Mutation_p.G477E|ACD_uc002etr.3_Missense_Mutation_p.G477E|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	480					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCCTGGGCTCCCCTGGTAGC	0.607													0	0	0	0.108266	0	25	85										T	67691914	C	T	67691914	3	4	25	1	0	0	0	0	1	0	0	0	135	855	30	1	207	1	ACD	16	67691914	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	9672078	67691914	22662839	181	7095										
CIRH1A	84916	broad.mit.edu	37	chr16	69199280	69199280	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcccagacaaacagtatacaGattggagccggactgtccag	10	11	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:69199280G>C	uc002ews.3	+	15	1780	c.1684G>C	c.(1684-1686)GAT>CAT	p.D562H	CIRH1A_uc002ewr.2_Missense_Mutation_p.D562H|CIRH1A_uc002ewt.3_Missense_Mutation_p.D479H|CIRH1A_uc010cfi.2_Missense_Mutation_p.D364H	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	562	WD 11.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		ACAGTATACAGATTGGAGCCG	0.488													0	0	0	0.069234	0	11	52										C	69199280	G	C	69199280	3	2	25	1	0	0	0	0	1	0	0	0	3434	942	33	1	1738	1	CIRH1A	16	69199280	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1507366	69199280	21155473	182	7096										
SPAG7	9552	broad.mit.edu	37	chr17	4863785	4863785	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctcgatcttgttcattggctGaaactttttcttgatctgcc	7	10	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:4863785G>A	uc002gae.2	-	3	244	c.211C>T	c.(211-213)CAG>TAG	p.Q71*	SPAG7_uc002gad.2_Nonsense_Mutation_p.Q20*|SPAG7_uc002gaf.2_Nonsense_Mutation_p.Q71*	NM_004890	NP_004881	O75391	SPAG7_HUMAN	sperm associated antigen 7	71	R3H.					nucleus	nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2						TTCATTGGCTGAAACTTTTTC	0.532													0	0	0	0.139131	0	59	67										A	4863785	G	A	4863785	4	1	25	1	0	0	0	0	0	1	0	0	14983	1299	45	1	492	1	SPAG7	17	4863785	Nonsense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		4863785	76331425	183	7097										
USP43	124739	broad.mit.edu	37	chr17	9559744	9559744	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagtttccaagtacggctctCagttccaaggcaattcccag	8	13	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:9559744C>T	uc010cod.2	+	2	529	c.529C>T	c.(529-531)CAG>TAG	p.Q177*	USP43_uc002gma.3_5'UTR|USP43_uc010vva.1_Nonsense_Mutation_p.Q177*|USP43_uc010coe.2_Silent_p.L8L	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	177					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GTACGGCTCTCAGTTCCAAGG	0.522													0	0	0	0.115264	0	3	15										T	9559744	C	T	9559744	4	4	25	1	0	0	0	0	0	1	0	0	17071	827	29	1	535	1	USP43	17	9559744	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	4695959	9559744	71635466	184	7098										
MYH1	4619	broad.mit.edu	37	chr17	10400658	10400658	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aagttggtctaaagattcctCataagcattcttaatcttaa	5	7	4	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:10400658C>G	uc002gmo.2	-	32	4571	c.4477G>C	c.(4477-4479)GAG>CAG	p.E1493Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1493	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AAAGATTCCTCATAAGCATTC	0.343													0	0	0	0.062417	0	19	64										G	10400658	C	G	10400658	3	3	25	1	0	0	0	0	1	0	0	0	10029	835	29	1	1378	1	MYH1	17	10400658	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	840914	10400658	70794552	185	7099										
MYH1	4619	broad.mit.edu	37	chr17	10400727	10400727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cttttgagaagcttcaagttCagcatgagtttcttcacact	7	9	4	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:10400727C>G	uc002gmo.2	-	32	4502	c.4408G>C	c.(4408-4410)GAA>CAA	p.E1470Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1470	Potential.			E -> V (in Ref. 4; CAA27380).		muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GCTTCAAGTTCAGCATGAGTT	0.378													0	0	0	0.080935	0	10	48										G	10400727	C	G	10400727	3	3	25	1	0	0	0	0	1	0	0	0	10029	835	29	1	1447	1	MYH1	17	10400727	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	69	10400727	70794483	186	7100										
PHF12	57649	broad.mit.edu	37	chr17	27254016	27254016	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gcagcattattacctttcggCgaacagtgcaccggtgacac	10	12	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:27254016C>G	uc002hdg.1	-	3	844	c.314G>C	c.(313-315)CGC>CCC	p.R105P	PHF12_uc010wbb.1_Missense_Mutation_p.R87P|PHF12_uc002hdi.1_Missense_Mutation_p.R101P|PHF12_uc002hdj.1_Missense_Mutation_p.R105P|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdk.1_Missense_Mutation_p.R101P|uc002hdl.2_Intron|PHF12_uc002hdh.1_5'Flank	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	105	PHD-type 1.|Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TACCTTTCGGCGAACAGTGCA	0.493													0	0	0	0.038147	0	8	77										G	27254016	C	G	27254016	3	3	25	1	0	0	0	0	1	0	0	0	11823	768	27	4	2778	4	PHF12	17	27254016	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	16853289	27254016	53941194	187	7101										
WNK4	65266	broad.mit.edu	37	chr17	40936120	40936120	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cctactggctctgtcaaaatCggggacctgggcctggccac	12	14	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:40936120C>T	uc002ibj.2	+	3	978	c.957C>T	c.(955-957)ATC>ATT	p.I319I	WNK4_uc010wgx.1_Missense_Mutation_p.S13L|WNK4_uc002ibk.1_Silent_p.I91I|WNK4_uc010wgy.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	319	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTGTCAAAATCGGGGACCTGG	0.597													0	0	0	0.139131	0	64	202										T	40936120	C	T	40936120	2	4	25	1	0	0	0	0	0	0	0	1	17377	874	31	1		1	WNK4	17	40936120	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	13682104	40936120	40259090	188	7102										
CA10	56934	broad.mit.edu	37	chr17	49713340	49713340	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tctctggatatagttcctctAtattaagcccctgtagtaaa	6	9	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:49713340A>G	uc002itw.3	-	7	1651	c.665T>C	c.(664-666)ATA>ACA	p.I222T	CA10_uc002itu.3_Missense_Mutation_p.I151T|CA10_uc002itv.3_Missense_Mutation_p.I228T|CA10_uc002itx.3_Missense_Mutation_p.I222T|CA10_uc002ity.3_Missense_Mutation_p.I222T|CA10_uc002itz.2_Missense_Mutation_p.I222T	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	222					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TAGTTCCTCTATATTAAGCCC	0.368													0	0	0	0.045705	0	29	82										G	49713340	A	G	49713340	3	3	25	1	0	0	0	0	1	0	0	0	2511	449	16	5	333	5	CA10	17	49713340	Missense_Mutation	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	8777220	49713340	31481870	189	7103										
HELZ	9931	broad.mit.edu	37	chr17	65119237	65119237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggggtggaggagtatatgctCtaataggattgccaataagt	14	4	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:65119237C>G	uc010wqk.1	-	26	3669	c.3482G>C	c.(3481-3483)AGA>ACA	p.R1161T	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.R1160T	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGTATATGCTCTAATAGGATT	0.408													0	0	0	0.038395	0	18	45										G	65119237	C	G	65119237	3	3	25	1	0	0	0	0	1	0	0	0	7049	913	32	1	2381	1	HELZ	17	65119237	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	15405897	65119237	16075973	190	7104										
PSMD12	5718	broad.mit.edu	37	chr17	65340841	65340841	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	taattccattccatagtcctCaacaagtgtggaccaacgca	6	12	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:65340841C>A	uc002jfy.2	-	9	1050	c.964G>T	c.(964-966)GAG>TAG	p.E322*	PSMD12_uc002jga.2_Nonsense_Mutation_p.E302*|PSMD12_uc002jfz.2_Nonsense_Mutation_p.E263*	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	322	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					CCATAGTCCTCAACAAGTGTG	0.363													1	0	4.7546e-09	0.146539	5.02437e-09	13	61										A	65340841	C	A	65340841	4	1	25	1	0	0	0	0	0	1	0	0	12695	835	29	3	418	3	PSMD12	17	65340841	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	221604	65340841	15854369	191	7105										
ABCA8	10351	broad.mit.edu	37	chr17	66933153	66933153	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cctagcaagaacttcaaatgAtatgagtatgtattagtaaa	7	5	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:66933153A>G	uc002jhp.2	-	4	584	c.405T>C	c.(403-405)TAT>TAC	p.Y135Y	ABCA8_uc002jhq.2_Silent_p.Y135Y|ABCA8_uc010wqq.1_Silent_p.Y135Y|ABCA8_uc010wqr.1_Silent_p.Y74Y|ABCA8_uc002jhr.2_Silent_p.Y135Y|ABCA8_uc002jhs.2_Silent_p.Y135Y|ABCA8_uc002jht.2_Silent_p.Y135Y	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	135						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ACTTCAAATGATATGAGTATG	0.368													0	0	0	0.0918	0	25	55										G	66933153	A	G	66933153	2	3	25	1	0	0	0	0	0	0	0	1	38	340	12	5		5	ABCA8	17	66933153	Silent	SNP	A	TCGA-C4-A0F6-01A-11D-A10S-08	1592312	66933153	14262057	192	7106										
COG1	9382	broad.mit.edu	37	chr17	71197988	71197988	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caagaggttaaagaagtactCctccagcagagcgtgatggg	13	8	0	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:71197988C>T	uc002jjg.2	+	7	2058	c.2022C>T	c.(2020-2022)CTC>CTT	p.L674L	COG1_uc002jjh.2_Silent_p.L674L|COG1_uc002jjf.1_Silent_p.L674L	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	674					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			AAGAAGTACTCCTCCAGCAGA	0.463													0	0	0	0.0333	0	16	53										T	71197988	C	T	71197988	2	4	25	1	0	0	0	0	0	0	0	1	3657	842	30	1		1	COG1	17	71197988	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	4264835	71197988	9997222	193	7107										
DSG2	1829	broad.mit.edu	37	chr18	29101087	29101087	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aggttacgctttggatgcaaGaggaaacaatgtagagaaac	12	5	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr18:29101087G>A	uc002kwu.3	+	5	592	c.404G>A	c.(403-405)AGA>AAA	p.R135K		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	135	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TTGGATGCAAGAGGAAACAAT	0.343													0	0	0	0.076483	0	23	67										A	29101087	G	A	29101087	3	1	25	1	0	0	0	0	1	0	0	0	4777	942	33	1	422	1	DSG2	18	29101087	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		29101087	48976161	194	7108										
SETBP1	26040	broad.mit.edu	37	chr18	42530401	42530401	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agaaagcatttgacaatacaGaagggaaaagggaaggttat	12	3	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr18:42530401G>A	uc010dni.2	+	4	1392	c.1096G>A	c.(1096-1098)GAA>AAA	p.E366K		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	366						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGACAATACAGAAGGGAAAAG	0.453									Schinzel-Giedion_syndrome				0	0	0	0.055883	0	20	54										A	42530401	G	A	42530401	3	1	25	1	0	0	0	0	1	0	0	0	14129	943	33	1	1299	1	SETBP1	18	42530401	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	13429314	42530401	35546847	195	7109										
MALT1	10892	broad.mit.edu	37	chr18	56390314	56390314	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gcccttttgataggaaatatGaattaccgggagcaccccaa	9	10	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr18:56390314G>T	uc002lhm.1	+	10	1311	c.1053G>T	c.(1051-1053)ATG>ATT	p.M351I	MALT1_uc002lhn.1_Missense_Mutation_p.M340I	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	351	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						TAGGAAATATGAATTACCGGG	0.398			T	BIRC3	MALT								1	0	3.62473e-10	0.062417	3.84402e-10	19	63										T	56390314	G	T	56390314	3	4	25	1	0	0	0	0	1	0	0	0	9202	1290	45	3	1091	3	MALT1	18	56390314	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	13859913	56390314	21686934	196	7110										
MUM1	84939	broad.mit.edu	37	chr19	1357029	1357029	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttttggcccgaaccgcgactTcaacaaaaaataagagaaga	8	9	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:1357029T>G	uc010xgm.1	+	2	148	c.79T>G	c.(79-81)TCA>GCA	p.S27A	MUM1_uc010dsi.2_5'UTR|MUM1_uc002lrz.2_Missense_Mutation_p.S28A|MUM1_uc002lsb.2_5'UTR|MUM1_uc002lsc.1_5'Flank			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	27					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AACCGCGACTTCAACAAAAAA	0.358													0	0	0	0.062417	0	21	44										G	1357029	T	G	1357029	3	3	25	1	0	0	0	0	1	0	0	0	9985	1783	62	5	88	5	MUM1	19	1357029	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08		1357029	57771954	197	7111										
AP3D1	8943	broad.mit.edu	37	chr19	2130435	2130435	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gggtcctccagcttctccttCagccggggaaaggcagggcg	15	13	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2130435C>T	uc002luz.2	-	6	787	c.564G>A	c.(562-564)CTG>CTA	p.L188L	AP3D1_uc002luy.2_Intron|AP3D1_uc002lva.2_Silent_p.L188L	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	188	HEAT 4.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCTCCTTCAGCCGGGGAA	0.602													0	0	0	0.144211	0	32	75										T	2130435	C	T	2130435	2	4	25	1	0	0	0	0	0	0	0	1	746	813	29	1		1	AP3D1	19	2130435	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	773406	2130435	56998548	198	7112										
DOT1L	84444	broad.mit.edu	37	chr19	2216303	2216303	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agcattgtggagctagagaaGagccagcggcagcaggagct	16	8	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2216303G>A	uc002lvb.3	+	20	1983	c.1947G>A	c.(1945-1947)AAG>AAA	p.K649K	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_5'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	649						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTAGAGAAGAGCCAGCGGC	0.662													0	0	0	0.064281	0	32	69										A	2216303	G	A	2216303	2	1	25	1	0	0	0	0	0	0	0	1	4709	933	33	1		1	DOT1L	19	2216303	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	85868	2216303	56912680	199	7113										
DOT1L	84444	broad.mit.edu	37	chr19	2216319	2216319	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agaagagccagcggcagcagGagctcctgcagctcaagtcc	13	13	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2216319G>T	uc002lvb.3	+	20	1999	c.1963G>T	c.(1963-1965)GAG>TAG	p.E655*	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_5'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	655						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCAGCAGGAGCTCCTGCA	0.672													1	0	1.64293e-13	0.083992	1.74855e-13	23	52										T	2216319	G	T	2216319	4	4	25	1	0	0	0	0	0	1	0	0	4709	1175	41	3	2041	3	DOT1L	19	2216319	Nonsense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	16	2216319	56912664	200	7114										
JSRP1	126306	broad.mit.edu	37	chr19	2254207	2254207	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cgctccggctttcagcctctCcttccccgttcctggggtcc	9	19	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2254207C>G	uc002lvi.1	-	3	276	c.241G>C	c.(241-243)GAG>CAG	p.E81Q	JSRP1_uc002lvj.1_Missense_Mutation_p.E81Q	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	81						sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCAGCCTCTCCTTCCCCGTT	0.637											OREG0025137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	63	167										G	2254207	C	G	2254207	3	3	25	1	0	0	0	0	1	0	0	0	7966	864	30	1	770	1	JSRP1	19	2254207	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	37888	2254207	56874776	201	7115										
DPP9	91039	broad.mit.edu	37	chr19	4690967	4690967	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cttaatggggcacttaaattCatctggaaagaaagaaagaa	9	5	2	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:4690967C>G	uc002mba.2	-	14	1777	c.1519G>C	c.(1519-1521)GAA>CAA	p.E507Q		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	478					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CACTTAAATTCATCTGGAAAG	0.562													0	0	0	0.009096	0	4	13										G	4690967	C	G	4690967	3	3	25	1	0	0	0	0	1	0	0	0	4733	835	29	1	1195	1	DPP9	19	4690967	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2436760	4690967	54438016	202	7116										
SAFB2	9667	broad.mit.edu	37	chr19	5591776	5591776	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cacctgcccatcccggtggtCtcccatcattggcctcgaac	8	18	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:5591776C>G	uc002mcd.2	-	17	2589	c.2377G>C	c.(2377-2379)GAC>CAC	p.D793H		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	793	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TCCCGGTGGTCTCCCATCATT	0.592													0	0	0	0.105934	0	11	46										G	5591776	C	G	5591776	3	3	25	1	0	0	0	0	1	0	0	0	13807	913	32	1	504	1	SAFB2	19	5591776	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	900809	5591776	53537207	203	7117										
MYO1F	4542	broad.mit.edu	37	chr19	8587680	8587680	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccaggggcagggggccccctCtggcagaggggggcacccca	18	15	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:8587680C>G	uc002mkg.2	-	26	3002	c.2888G>C	c.(2887-2889)AGA>ACA	p.R963T		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	963				VPPSARGGPL -> APLCPQGGAPC (in Ref. 5; CAA67058).		unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GGGGCCCCCTCTGGCAGAGGG	0.652													0	0	0	0.009096	0	4	8										G	8587680	C	G	8587680	3	3	25	1	0	0	0	0	1	0	0	0	10073	913	32	1	420	1	MYO1F	19	8587680	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2995904	8587680	50541303	204	7118										
ADAMTS10	81794	broad.mit.edu	37	chr19	8670203	8670203	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttgtggtccacgcgggtgggGaaggcgatctcatagctctc	15	10	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:8670203G>T	uc002mkj.1	-	4	403	c.129C>A	c.(127-129)TTC>TTA	p.F43L	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	43					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CGCGGGTGGGGAAGGCGATCT	0.677													1	0	0.000442599	0.058154	0.000457967	10	13										T	8670203	G	T	8670203	3	4	25	1	0	0	0	0	1	0	0	0	256	1165	41	3	3274	3	ADAMTS10	19	8670203	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	82523	8670203	50458780	205	7119										
TNPO2	30000	broad.mit.edu	37	chr19	12826060	12826060	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccagcccagcggcccacctcGatgaaggtgtcaatattgtc	10	14	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:12826060G>A	uc002muo.2	-	7	830	c.645C>T	c.(643-645)ATC>ATT	p.I215I	TNPO2_uc002mup.2_Silent_p.I307I|TNPO2_uc002muq.2_Silent_p.I215I|TNPO2_uc002mur.2_Silent_p.I215I	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	215	HEAT 3.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						GGCCCACCTCGATGAAGGTGT	0.642													0	0	0	0.02938	0	7	18										A	12826060	G	A	12826060	2	1	25	1	0	0	0	0	0	0	0	1	16333	1048	37	1		1	TNPO2	19	12826060	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	4155857	12826060	46302923	206	7120										
ZNF569	148266	broad.mit.edu	37	chr19	37917250	37917250	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccactcctcctgagtgaagtCgatagccacatctttgaatg	8	12	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:37917250C>T	uc002ogi.2	-	4	604	c.46G>A	c.(46-48)GAC>AAC	p.D16N	ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Missense_Mutation_p.D40N	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	16	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAGTGAAGTCGATAGCCACA	0.398													0	0	0	0.139131	0	59	110										T	37917250	C	T	37917250	3	4	25	1	0	0	0	0	1	0	0	0	17997	884	31	1	2026	1	ZNF569	19	37917250	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	25091190	37917250	21211733	207	7121										
PRX	57716	broad.mit.edu	37	chr19	40900472	40900472	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctcggcccctgggggctgctCctcagcaccctcgcccccca	10	22	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40900472C>G	uc002onr.2	-	7	4056	c.3787G>C	c.(3787-3789)GAG>CAG	p.E1263Q	PRX_uc002onq.2_Missense_Mutation_p.E1124Q|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1263					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGGGGCTGCTCCTCAGCACCC	0.706													0	0	0	0.058154	0	10	24										G	40900472	C	G	40900472	3	3	25	1	0	0	0	0	1	0	0	0	12642	864	30	1	602	1	PRX	19	40900472	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2983222	40900472	18228511	208	7122			1	21		6	6	1132	C		5.107725e-13
PRX	57716	broad.mit.edu	37	chr19	40901150	40901150	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agccacccctggcactagttCtgctgcctcagtgtcccggc	10	17	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901150C>G	uc002onr.2	-	7	3378	c.3109G>C	c.(3109-3111)GAA>CAA	p.E1037Q	PRX_uc002onq.2_Missense_Mutation_p.E898Q|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1037					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCACTAGTTCTGCTGCCTCA	0.627													0	0	0	0.069288	0	22	140										G	40901150	C	G	40901150	3	3	25	1	0	0	0	0	1	0	0	0	12642	922	32	1	1280	1	PRX	19	40901150	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	678	40901150	18227833	209	7123			1	21		6	6	1132	C		5.107725e-13
PRX	57716	broad.mit.edu	37	chr19	40901173	40901173	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgcctcagtgtcccggcctCtgaccccaaacttggggaga	11	15	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901173C>G	uc002onr.2	-	7	3355	c.3086G>C	c.(3085-3087)AGA>ACA	p.R1029T	PRX_uc002onq.2_Missense_Mutation_p.R890T|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1029					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTCCCGGCCTCTGACCCCAAA	0.637													0	0	0	0.134883	0	26	152										G	40901173	C	G	40901173	3	3	25	1	0	0	0	0	1	0	0	0	12642	913	32	1	1303	1	PRX	19	40901173	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	23	40901173	18227810	210	7124			1	21		6	6	1132	C		5.107725e-13
PRX	57716	broad.mit.edu	37	chr19	40901264	40901264	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gcctgagggcaggtgggcatCcaggctgagctgtgggatgg	20	8	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901264C>G	uc002onr.2	-	7	3264	c.2995G>C	c.(2995-2997)GAT>CAT	p.D999H	PRX_uc002onq.2_Missense_Mutation_p.D860H|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	999					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGTGGGCATCCAGGCTGAGC	0.667													0	0	0	0.144211	0	29	139										G	40901264	C	G	40901264	3	3	25	1	0	0	0	0	1	0	0	0	12642	855	30	1	1394	1	PRX	19	40901264	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	91	40901264	18227719	211	7125			1	21		6	6	1132	C		5.107725e-13
PRX	57716	broad.mit.edu	37	chr19	40901420	40901420	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tcgcccagccccctcagcctCtgccttagccacctttggcc	7	21	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901420C>T	uc002onr.2	-	7	3108	c.2839G>A	c.(2839-2841)GAG>AAG	p.E947K	PRX_uc002onq.2_Missense_Mutation_p.E808K|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	947					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCCTCAGCCTCTGCCTTAGCC	0.577													0	0	0	0.139131	0	51	239										T	40901420	C	T	40901420	3	4	25	1	0	0	0	0	1	0	0	0	12642	922	32	1	1550	1	PRX	19	40901420	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	156	40901420	18227563	212	7126			1	21		6	6	1132	C		5.107725e-13
PRX	57716	broad.mit.edu	37	chr19	40901603	40901603	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cctgacccctgctgccacctCagggccctccacccgctctc	7	23	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901603C>G	uc002onr.2	-	7	2925	c.2656G>C	c.(2656-2658)GAG>CAG	p.E886Q	PRX_uc002onq.2_Missense_Mutation_p.E747Q|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	886					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTGCCACCTCAGGGCCCTCC	0.637													0	0	0	0.050027	0	13	114										G	40901603	C	G	40901603	3	3	25	1	0	0	0	0	1	0	0	0	12642	835	29	1	1733	1	PRX	19	40901603	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	183	40901603	18227380	213	7127			1	21		6	6	1132	C		5.107725e-13
CEACAM21	90273	broad.mit.edu	37	chr19	42082676	42082676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agaatgcatcccctggcaggGgctcttgctcacaggtgagg	14	11	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:42082676G>A	uc002ore.3	+	1	146	c.50G>A	c.(49-51)GGG>GAG	p.G17E	CEACAM21_uc002orc.1_Intron|CEACAM21_uc002ord.1_Intron|CEACAM21_uc002orf.2_RNA|CEACAM21_uc002org.3_Missense_Mutation_p.G17E	NM_001098506	NP_001091976	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion	17						integral to membrane				ovary(1)	1						CCCTGGCAGGGGCTCTTGCTC	0.652													0	0	0	0.047766	0	9	55										A	42082676	G	A	42082676	3	1	25	1	0	0	0	0	1	0	0	0	3192	1232	43	2	52	2	CEACAM21	19	42082676	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1181073	42082676	17046307	214	7128										
ALDH16A1	126133	broad.mit.edu	37	chr19	49971800	49971800	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgcccagtgcggcctgtcctCtgctggccctggaggtctgc	14	15	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:49971800C>T	uc002pnt.2	+	15	2217	c.2101C>T	c.(2101-2103)CTG>TTG	p.L701L	ALDH16A1_uc010yar.1_Silent_p.L650L|ALDH16A1_uc010yas.1_Silent_p.L536L|ALDH16A1_uc010yat.1_Silent_p.L538L	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	701							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GGCCTGTCCTCTGCTGGCCCT	0.667													0	0	0	0.11911	0	14	274										T	49971800	C	T	49971800	2	4	25	1	0	0	0	0	0	0	0	1	488	912	32	1		1	ALDH16A1	19	49971800	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	7889124	49971800	9157183	215	7129										
KLK14	43847	broad.mit.edu	37	chr19	51582812	51582812	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	actgccctcccgatccgtgcGggctgctgtagctgcagcag	13	15	0	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:51582812G>A	uc002pvs.1	-	5	627	c.408C>T	c.(406-408)CCC>CCT	p.P136P		NM_022046	NP_071329	Q9P0G3	KLK14_HUMAN	kallikrein 14 preproprotein	136	Peptidase S1.				epidermis morphogenesis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis|seminal clot liquefaction	extracellular space	serine-type endopeptidase activity			skin(1)	1		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00422)		CGATCCGTGCGGGCTGCTGTA	0.657													0	0	0	0.069234	0	8	48										A	51582812	G	A	51582812	2	1	25	1	0	0	0	0	0	0	0	1	8402	1103	39	2		2	KLK14	19	51582812	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	1611012	51582812	7546171	216	7130										
ZNF677	342926	broad.mit.edu	37	chr19	53741588	53741588	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tattatgttgttgatcttttCtgtgagtgagatttttgtta	9	2	2	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:53741588C>T	uc002qbf.1	-	5	577	c.392G>A	c.(391-393)AGA>AAA	p.R131K	ZNF677_uc002qbg.1_Missense_Mutation_p.R131K	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TTGATCTTTTCTGTGAGTGAG	0.358													0	0	0	0.117977	0	43	115										T	53741588	C	T	53741588	3	4	25	1	0	0	0	0	1	0	0	0	18081	913	32	1	1366	1	ZNF677	19	53741588	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	2158776	53741588	5387395	217	7131										
PRKCG	5582	broad.mit.edu	37	chr19	54403944	54403944	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ttggcatgtgtaaggagaacGtcttccccgggacgacaacc	12	11	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:54403944G>A	uc002qcq.1	+	14	1798	c.1516G>A	c.(1516-1518)GTC>ATC	p.V506I	PRKCG_uc010yeg.1_Missense_Mutation_p.V506I|PRKCG_uc010yeh.1_Missense_Mutation_p.V393I	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	506	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TAAGGAGAACGTCTTCCCCGG	0.587													0	0	0	0.139131	0	435	273										A	54403944	G	A	54403944	3	1	25	1	0	0	0	0	1	0	0	0	12512	1145	40	2	1570	2	PRKCG	19	54403944	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	662356	54403944	4725039	218	7132										
CNOT3	4849	broad.mit.edu	37	chr19	54656169	54656169	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cccaccctccccacagacatCatcctgagcagtacatcagc	5	19	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:54656169C>A	uc002qdj.1	+	15	2021	c.1710C>A	c.(1708-1710)ATC>ATA	p.I570I	CNOT3_uc010yel.1_Silent_p.I570I|CNOT3_uc002qdi.2_Silent_p.I483I|CNOT3_uc002qdk.1_Silent_p.I570I|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_Silent_p.I25I	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	570	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCACAGACATCATCCTGAGCA	0.667													1	0	5.99346e-17	0.139131	6.42464e-17	54	305										A	54656169	C	A	54656169	2	1	25	1	0	0	0	0	0	0	0	1	3620	816	29	3		3	CNOT3	19	54656169	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	252225	54656169	4472814	219	7133										
ZNF671	79891	broad.mit.edu	37	chr19	58232870	58232870	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agaattgctttccacatgccCcacacaagtatggtttctgc	7	12	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:58232870C>T	uc002qpz.3	-	4	683	c.584G>A	c.(583-585)GGG>GAG	p.G195E	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Missense_Mutation_p.G118E|ZNF671_uc010yhf.1_Missense_Mutation_p.G97E	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	195	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCCACATGCCCCACACAAGTA	0.488													0	0	0	0.139131	0	57	209										T	58232870	C	T	58232870	3	4	25	1	0	0	0	0	1	0	0	0	18075	623	22	2	1024	2	ZNF671	19	58232870	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	3576701	58232870	896113	220	7134										
NSFL1C	55968	broad.mit.edu	37	chr20	1433180	1433180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagtgaaggctttgaaggctCctttgggcttcacaaagtcc	11	10	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:1433180C>T	uc002wfc.2	-	7	1691	c.743G>A	c.(742-744)GGA>GAA	p.G248E	NSFL1C_uc002wfd.2_Missense_Mutation_p.G137E|NSFL1C_uc002wfe.2_Missense_Mutation_p.G217E|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Missense_Mutation_p.G14E	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	248						chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						TTTGAAGGCTCCTTTGGGCTT	0.577													0	0	0	0.139131	0	146	330										T	1433180	C	T	1433180	3	4	25	1	0	0	0	0	1	0	0	0	10672	855	30	1	381	1	NSFL1C	20	1433180	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		1433180	61592340	221	7135										
TASP1	55617	broad.mit.edu	37	chr20	13463978	13463978	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tggtgcgcacaagatgctctCcacatcctagaaatccaaag	8	12	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:13463978C>G	uc002woi.2	-	11	998	c.881G>C	c.(880-882)GGA>GCA	p.G294A	TASP1_uc010zri.1_RNA|TASP1_uc002woh.2_Missense_Mutation_p.G271A|TASP1_uc010zrj.1_RNA	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	294					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						AAGATGCTCTCCACATCCTAG	0.433													0	0	0	0.139131	0	59	154										G	13463978	C	G	13463978	3	3	25	1	0	0	0	0	1	0	0	0	15586	855	30	1	397	1	TASP1	20	13463978	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	12030798	13463978	49561542	222	7136										
SLC32A1	140679	broad.mit.edu	37	chr20	37353313	37353313	+	Translation_Start_Site	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cagccctcgccttcttgcatCgcgttccccgcatcctcggg	9	19	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:37353313C>G	uc002xjc.2	+	1	209	c.-54C>G	c.(-56--52)ATCGC>ATGGC			NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1						neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CTTCTTGCATCGCGTTCCCCG	0.692													0	0	0	0.038147	0	8	57										G	37353313	C	G	37353313	1	3	25	1	0	0	0	0	0	0	0	0	14565	899	31	1		1	SLC32A1	20	37353313	Translation_Start_Site	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	23889335	37353313	25672207	223	7137										
NCOA5	57727	broad.mit.edu	37	chr20	44699006	44699006	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cctgctgtctctgtgatcccGcaaatctctactatgtctgt	7	13	3	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:44699006G>A	uc002xrd.2	-	2	736	c.208C>T	c.(208-210)CGG>TGG	p.R70W	NCOA5_uc002xrc.2_5'UTR|NCOA5_uc002xre.2_Missense_Mutation_p.R70W	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	70	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				CTGTGATCCCGCAAATCTCTA	0.562													0	0	0	0.021553	0	6	330										A	44699006	G	A	44699006	3	1	25	1	0	0	0	0	1	0	0	0	10232	1086	38	2	1555	2	NCOA5	20	44699006	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	7345693	44699006	18326514	224	7138										
CDH22	64405	broad.mit.edu	37	chr20	44841804	44841804	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cgttccaatgggggctgactCctggatgctgaactggtaca	13	10	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:44841804C>G	uc002xrm.2	-	5	1263	c.862G>C	c.(862-864)GAG>CAG	p.E288Q	CDH22_uc010ghk.1_Missense_Mutation_p.E288Q|CDH22_uc002xrn.1_Missense_Mutation_p.E39Q	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	288	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGGGCTGACTCCTGGATGCTG	0.597													0	0	0	0.139131	0	52	67										G	44841804	C	G	44841804	3	3	25	1	0	0	0	0	1	0	0	0	3107	864	30	1	1652	1	CDH22	20	44841804	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	142798	44841804	18183716	225	7139										
KCNG1	3755	broad.mit.edu	37	chr20	49626376	49626376	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caatcttctgcaggtagcggCgcttgcagcagccgtccagg	13	13	2	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:49626376C>T	uc002xwa.3	-	2	795	c.500G>A	c.(499-501)CGC>CAC	p.R167H	KCNG1_uc002xwb.2_Missense_Mutation_p.R167H	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	167	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						CAGGTAGCGGCGCTTGCAGCA	0.687													0	0	0	0.134883	0	28	150										T	49626376	C	T	49626376	3	4	25	1	0	0	0	0	1	0	0	0	8027	768	27	2	1049	2	KCNG1	20	49626376	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	4784572	49626376	13399144	226	7140										
BCAS1	8537	broad.mit.edu	37	chr20	52645197	52645197	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggccggggcgtgccctggggTtttatctgtgtcctgccccg	16	13	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:52645197T>A	uc002xws.2	-	4	795	c.457A>T	c.(457-459)ACC>TCC	p.T153S	BCAS1_uc010zzb.1_Missense_Mutation_p.T56S|BCAS1_uc010gim.2_Missense_Mutation_p.T56S|BCAS1_uc002xwt.2_Missense_Mutation_p.T153S|BCAS1_uc010gil.1_Missense_Mutation_p.T153S|BCAS1_uc010zzc.1_Missense_Mutation_p.T56S	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	153						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TGCCCTGGGGTTTTATCTGTG	0.612													0	0	0	0.139131	0	104	121										A	52645197	T	A	52645197	3	1	25	1	0	0	0	0	1	0	0	0	1350	1725	60	5	1333	5	BCAS1	20	52645197	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	3018821	52645197	10380323	227	7141										
ADAMTS1	9510	broad.mit.edu	37	chr21	28214229	28214229	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aaaccatcatcttctatgacGgagcagcttctgctcggatc	8	12	4	1	rs141975781		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr21:28214229G>A	uc002ymf.2	-	3	1613	c.1158C>T	c.(1156-1158)TCC>TCT	p.S386S		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	386	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		CTTCTATGACGGAGCAGCTTC	0.438													0	0	0	0.069456	0	38	84										A	28214229	G	A	28214229	2	1	25	1	0	0	0	0	0	0	0	1	255	1103	39	2		2	ADAMTS1	21	28214229	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		28214229	19915666	228	7142										
TFF2	7032	broad.mit.edu	37	chr21	43767668	43767668	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aagcagcacttccgagaggcGcattcctcggggctgatgcc	13	13	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr21:43767668G>A	uc002zaw.2	-	3	445	c.303C>T	c.(301-303)TGC>TGT	p.C101C		NM_005423	NP_005414	Q03403	TFF2_HUMAN	trefoil factor 2 precursor	101	P-type 2.				digestion	extracellular region				pancreas(1)	1						TCCGAGAGGCGCATTCCTCGG	0.577													0	0	0	0.058154	0	10	51										A	43767668	G	A	43767668	2	1	25	1	0	0	0	0	0	0	0	1	15801	1079	38	2		2	TFF2	21	43767668	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	15553439	43767668	4362227	229	7143										
MYO18B	84700	broad.mit.edu	37	chr22	26286747	26286747	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ctgacttgacctctgaccttGccgatgagcgcttcaaaggt	10	12	2	4			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr22:26286747G>A	uc003abz.1	+	26	4589	c.4339G>A	c.(4339-4341)GCC>ACC	p.A1447T	MYO18B_uc003aca.1_Missense_Mutation_p.A1328T|MYO18B_uc010guy.1_Missense_Mutation_p.A1329T|MYO18B_uc010guz.1_Missense_Mutation_p.A1328T|MYO18B_uc011aka.1_Missense_Mutation_p.A601T|MYO18B_uc011akb.1_Missense_Mutation_p.A960T	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1447	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CTCTGACCTTGCCGATGAGCG	0.592													0	0	0	0.139131	0	65	24										A	26286747	G	A	26286747	3	1	25	1	0	0	0	0	1	0	0	0	10066	1319	46	2	4437	2	MYO18B	22	26286747	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08		26286747	25017819	230	7144										
SF3A1	10291	broad.mit.edu	37	chr22	30748978	30748978	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gtcttgtcaacaatatttctGacctctggaggagggtaaat	10	7	4	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr22:30748978G>C	uc003ahl.2	-	2	279	c.147C>G	c.(145-147)GTC>GTG	p.V49V		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	49					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						CAATATTTCTGACCTCTGGAG	0.478													0	0	0	0.116897	0	29	172										C	30748978	G	C	30748978	2	2	25	1	0	0	0	0	0	0	0	1	14146	1277	45	1		1	SF3A1	22	30748978	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	4462231	30748978	20555588	231	7145										
CELSR1	9620	broad.mit.edu	37	chr22	46792543	46792543	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tagtgactgggcccacactcGcacacgtagccctgcgggga	13	14	0	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr22:46792543G>A	uc003bhw.1	-	13	5802	c.5802C>T	c.(5800-5802)TGC>TGT	p.C1934C	CELSR1_uc011arc.1_Silent_p.C255C	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1934	Extracellular (Potential).|EGF-like 6; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCCCACACTCGCACACGTAGC	0.622													0	0	0	0.02938	0	7	20										A	46792543	G	A	46792543	2	1	25	1	0	0	0	0	0	0	0	1	3221	1079	38	2		2	CELSR1	22	46792543	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	16043565	46792543	4512023	232	7146										
KAL1	3730	broad.mit.edu	37	chrX	8507728	8507728	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggtcatgccagatgatgcctCtgatccggttgttctgttgt	12	9	3	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:8507728C>T	uc004csf.2	-	10	1576	c.1426G>A	c.(1426-1428)GAG>AAG	p.E476K		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	476	Fibronectin type-III 3.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						GATGATGCCTCTGATCCGGTT	0.453													0	0	0	0.139131	0	48	259										T	8507728	C	T	8507728	3	4	25	1	0	0	0	0	1	0	0	0	7974	922	32	1	636	1	KAL1	23	8507728	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08		8507728	146762832	233	7147										
DMD	1756	broad.mit.edu	37	chrX	31645811	31645811	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tgccattgtttcatcagctcTtttactcccttggagtcttc	6	12	4	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:31645811T>G	uc004dda.1	-	55	8440	c.8196A>C	c.(8194-8196)AAA>AAC	p.K2732N	DMD_uc004dcr.1_Missense_Mutation_p.K272N|DMD_uc004dcs.1_Missense_Mutation_p.K272N|DMD_uc004dct.1_Missense_Mutation_p.K272N|DMD_uc004dcu.1_Missense_Mutation_p.K272N|DMD_uc004dcv.1_Missense_Mutation_p.K272N|DMD_uc004dcw.2_Missense_Mutation_p.K1388N|DMD_uc004dcx.2_Missense_Mutation_p.K1391N|DMD_uc004dcz.2_Missense_Mutation_p.K2609N|DMD_uc004dcy.1_Missense_Mutation_p.K2728N|DMD_uc004ddb.1_Missense_Mutation_p.K2724N	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2732	Spectrin 19.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCATCAGCTCTTTTACTCCCT	0.433													0	0	0	0.049695	0	15	90										G	31645811	T	G	31645811	3	3	25	1	0	0	0	0	1	0	0	0	4580	1606	56	5	3109	5	DMD	23	31645811	Missense_Mutation	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	23138083	31645811	123624749	234	7148										
EFHC2	80258	broad.mit.edu	37	chrX	44108098	44108098	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cttggttctttataaagtcaCcatatgaattgagaactgct	7	7	2	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:44108098C>T	uc004dgb.3	-	7	1013	c.923G>A	c.(922-924)GGT>GAT	p.G308D		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	308	DM10 2.						calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6						TATAAAGTCACCATATGAATT	0.378													0	0	0	0.092188	0	38	45										T	44108098	C	T	44108098	3	4	25	1	0	0	0	0	1	0	0	0	4947	507	18	2	1366	2	EFHC2	23	44108098	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	12462287	44108098	111162462	235	7149										
KDM6A	7403	broad.mit.edu	37	chrX	44938512	44938512	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	cccactggaacaaagaaaatCtggcattgtgaaagtaatag	9	7	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:44938512C>T	uc004dge.3	+	20	3435	c.3060C>T	c.(3058-3060)ATC>ATT	p.I1020I	KDM6A_uc010nhk.2_Silent_p.I986I|KDM6A_uc011mkz.1_Silent_p.I1072I|KDM6A_uc011mla.1_Silent_p.I975I|KDM6A_uc011mlb.1_Silent_p.I1027I|KDM6A_uc011mlc.1_Silent_p.I724I|KDM6A_uc011mld.1_Silent_p.I659I	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1020					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CAAAGAAAATCTGGCATTGTG	0.403			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.139131	0	48	100										T	44938512	C	T	44938512	2	4	25	1	0	0	0	0	0	0	0	1	8137	903	32	1		1	KDM6A	23	44938512	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	830414	44938512	110332048	236	7150										
HUWE1	10075	broad.mit.edu	37	chrX	53603879	53603879	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ccttcctctggagcatggtaTgcagccagagcattcagcat	10	12	2	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:53603879T>C	uc004dsp.2	-	44	6267	c.5865A>G	c.(5863-5865)GCA>GCG	p.A1955A	HUWE1_uc004dsn.2_Silent_p.A780A	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1955					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GAGCATGGTATGCAGCCAGAG	0.383													0	0	0	0.139131	0	45	68										C	53603879	T	C	53603879	2	2	25	1	0	0	0	0	0	0	0	1	7461	1451	51	5		5	HUWE1	23	53603879	Silent	SNP	T	TCGA-C4-A0F6-01A-11D-A10S-08	8665367	53603879	101666681	237	7151										
FAM120C	54954	broad.mit.edu	37	chrX	54143003	54143003	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tacacaacacatgagcagcaGatgggtggggacattagctg	13	8	0	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:54143003G>C	uc004dsz.3	-	10	2370	c.2287C>G	c.(2287-2289)CTG>GTG	p.L763V	FAM120C_uc011moh.1_Missense_Mutation_p.L763V	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	763										ovary(1)|central_nervous_system(1)	2						ATGAGCAGCAGATGGGTGGGG	0.478													0	0	0	0.146539	0	14	83										C	54143003	G	C	54143003	3	2	25	1	0	0	0	0	1	0	0	0	5418	933	33	1	1031	1	FAM120C	23	54143003	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	539124	54143003	101127557	238	7152										
STARD8	9754	broad.mit.edu	37	chrX	67940785	67940785	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggtaggcatcttccgcaagtCtggggtcaagtccaggatcc	13	11	3	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:67940785C>T	uc004dxa.2	+	8	2201	c.1829C>T	c.(1828-1830)TCT>TTT	p.S610F	STARD8_uc004dxb.2_Missense_Mutation_p.S690F|STARD8_uc004dxc.3_Missense_Mutation_p.S610F	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	610	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						TTCCGCAAGTCTGGGGTCAAG	0.572													0	0	0	0.069456	0	36	39										T	67940785	C	T	67940785	3	4	25	1	0	0	0	0	1	0	0	0	15262	913	32	1	2103	1	STARD8	23	67940785	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	13797782	67940785	87329775	239	7153										
MED12	9968	broad.mit.edu	37	chrX	70345221	70345221	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaggagtcatgcagccatgaGtgcaaccagcggttggtcgt	15	9	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:70345221G>T	uc004dyy.2	+	16	2446	c.2247G>T	c.(2245-2247)GAG>GAT	p.E749D	MED12_uc011mpq.1_Missense_Mutation_p.E749D|MED12_uc004dyz.2_Missense_Mutation_p.E749D|MED12_uc004dza.2_Missense_Mutation_p.E596D	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	749					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GCAGCCATGAGTGCAACCAGC	0.542													1	0	3.76525e-18	0.139131	4.08016e-18	46	26										T	70345221	G	T	70345221	3	4	25	1	0	0	0	0	1	0	0	0	9428	1020	36	4	2309	4	MED12	23	70345221	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	2404436	70345221	84925339	240	7154										
TAF1	6872	broad.mit.edu	37	chrX	70608124	70608124	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tttctggaaaagtaaagatcGgccacggaggatacgaatgg	13	6	1	1			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:70608124G>A	uc004dzu.3	+	16	2513	c.2462G>A	c.(2461-2463)CGG>CAG	p.R821Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.R842Q|TAF1_uc004dzv.3_5'UTR	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	821					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AGTAAAGATCGGCCACGGAGG	0.433													0	0	0	0.139131	0	104	82										A	70608124	G	A	70608124	3	1	25	1	0	0	0	0	1	0	0	0	15510	1116	39	2	2587	2	TAF1	23	70608124	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	262903	70608124	84662436	241	7155										
GPR174	84636	broad.mit.edu	37	chrX	78427144	78427144	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	agacggttttatcactgcaaGataaatatcccatggcccaa	7	10	1	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:78427144G>A	uc004edg.1	+	1	676	c.640G>A	c.(640-642)GAT>AAT	p.D214N		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	214	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						ATCACTGCAAGATAAATATCC	0.428										HNSCC(63;0.18)			0	0	0	0.059317	0	31	99										A	78427144	G	A	78427144	3	1	25	1	0	0	0	0	1	0	0	0	6672	942	33	1	642	1	GPR174	23	78427144	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	7819020	78427144	76843416	242	7156										
DRP2	1821	broad.mit.edu	37	chrX	100513302	100513302	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	tctctctccatggcaggattCtccagggagagctgaggcgc	13	12	3	2			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:100513302C>T	uc004egz.2	+	22	2764	c.2395C>T	c.(2395-2397)CTC>TTC	p.L799F	DRP2_uc011mrh.1_Missense_Mutation_p.L721F	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	799					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TGGCAGGATTCTCCAGGGAGA	0.587													0	0	0	0.02938	0	3	6										T	100513302	C	T	100513302	3	4	25	1	0	0	0	0	1	0	0	0	4764	913	32	1	2473	1	DRP2	23	100513302	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	22086158	100513302	54757258	243	7157										
HTR2C	3358	broad.mit.edu	37	chrX	114141690	114141690	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	ggctatgtttgttcaggaatCaatcctctggtgtatactct	9	8	4	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:114141690C>T	uc004epu.1	+	6	1817	c.1089C>T	c.(1087-1089)ATC>ATT	p.I363I	HTR2C_uc010nqc.1_Silent_p.I363I|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	363	Helical; Name=7; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	GTTCAGGAATCAATCCTCTGG	0.398													0	0	0	0.139131	0	139	155										T	114141690	C	T	114141690	2	4	25	1	0	0	0	0	0	0	0	1	7443	816	29	1		1	HTR2C	23	114141690	Silent	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	13628388	114141690	41128870	244	7158										
GLUD2	2747	broad.mit.edu	37	chrX	120183007	120183007	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aactattcccattgtacccaCggcagagttccaagacagta	7	12	0	2	rs141237083		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:120183007C>T	uc004eto.2	+	1	1546	c.1469C>T	c.(1468-1470)ACG>ATG	p.T490M		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	490					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATTGTACCCACGGCAGAGTTC	0.438													0	0	0	0.139131	0	111	111										T	120183007	C	T	120183007	3	4	25	1	0	0	0	0	1	0	0	0	6477	536	19	2	1471	2	GLUD2	23	120183007	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	6041317	120183007	35087553	245	7159										
UTP14A	10813	broad.mit.edu	37	chrX	129059059	129059059	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaggaccccaaataatcgccCtgatgcccctaaggagaaga	10	12	0	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:129059059C>G	uc004euz.2	+	12	1665	c.1637C>G	c.(1636-1638)CCT>CGT	p.P546R	UTP14A_uc011mup.1_Missense_Mutation_p.P494R|UTP14A_uc011muq.1_Missense_Mutation_p.P492R	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	546					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						AATAATCGCCCTGATGCCCCT	0.478													0	0	0	0.139131	0	165	163										G	129059059	C	G	129059059	3	3	25	1	0	0	0	0	1	0	0	0	17092	681	24	4	1683	4	UTP14A	23	129059059	Missense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	8876052	129059059	26211501	246	7160										
MAGEC1	9947	broad.mit.edu	37	chrX	140995585	140995585	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	aaagttcccatgagagtcctCagagtcctcctgaggggcct	11	12	1	3			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:140995585C>T	uc004fbt.2	+	4	2681	c.2395C>T	c.(2395-2397)CAG>TAG	p.Q799*	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	799							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGAGTCCTCAGAGTCCTCC	0.567										HNSCC(15;0.026)			0	0	0	0.139131	0	204	343										T	140995585	C	T	140995585	4	4	25	1	0	0	0	0	0	1	0	0	9180	827	29	1	2401	1	MAGEC1	23	140995585	Nonsense_Mutation	SNP	C	TCGA-C4-A0F6-01A-11D-A10S-08	11936526	140995585	14274975	247	7161										
SPANXN1	494118	broad.mit.edu	37	chrX	144337274	144337274	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	gaatattcaacagtattagcGttttgctacaggaaagctaa	8	6	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:144337274G>A	uc004fcb.2	+	2	159	c.159G>A	c.(157-159)GCG>GCA	p.A53A		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	53											0	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTATTAGCGTTTTGCTACA	0.433													0	0	0	0.139131	0	88	129										A	144337274	G	A	144337274	2	1	25	1	0	0	0	0	0	0	0	1	14990	1132	40	2		2	SPANXN1	23	144337274	Silent	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	3341689	144337274	10933286	248	7162										
UBL4A	8266	broad.mit.edu	37	chrX	153713943	153713943	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.42570281124498	106	8.00704673735311e-36	3.76482709070452	5.57187479231741	2.51963455682	0.0055266850250947	0.019418082520603	78	caggaagcggctggccaaccGttcgatgtcgtccagcgtca	13	13	1	0			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:153713943G>A	uc004flo.2	-	4	418	c.409C>T	c.(409-411)CGG>TGG	p.R137W		NM_014235	NP_055050	P11441	UBL4A_HUMAN	ubiquitin-like 4	137					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGGCCAACCGTTCGATGTCG	0.602													0	0	0	0.139131	0	45	223										A	153713943	G	A	153713943	3	1	25	1	0	0	0	0	1	0	0	0	16884	1144	40	2	68	2	UBL4A	23	153713943	Missense_Mutation	SNP	G	TCGA-C4-A0F6-01A-11D-A10S-08	9376669	153713943	1556617	249	7163										
PRDM2	7799	broad.mit.edu	37	chr1	14107286	14107286	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cgtacctcttccagccccctCttccagtgcatctccacacc	4	21	3	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:14107286C>A	uc001avi.2	+	8	3852	c.2996C>A	c.(2995-2997)TCT>TAT	p.S999Y	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S999Y|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S798Y|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	999	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CCAGCCCCCTCTTCCAGTGCA	0.607													1	0	5.34484e-38	0.01441	6.14407e-38	94	67										A	14107286	C	A	14107286	3	1	26	1	0	0	0	0	1	0	0	0	12458	913	32	3	3022	3	PRDM2	1	14107286	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		14107286	235143335	1	7164										
UBR4	23352	broad.mit.edu	37	chr1	19475090	19475090	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gggccaacggcaaagcagctTtccagggcttctaaagaact	11	11	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:19475090T>A	uc001bbi.2	-	50	7465	c.7461A>T	c.(7459-7461)GAA>GAT	p.E2487D	UBR4_uc001bbk.1_Missense_Mutation_p.E141D	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2487					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAAAGCAGCTTTCCAGGGCTT	0.512													0	0	0	0.01441	0	134	119										A	19475090	T	A	19475090	3	1	26	1	0	0	0	0	1	0	0	0	16901	1838	64	5	8318	5	UBR4	1	19475090	Missense_Mutation	SNP	T	TCGA-C4-A0F7-01A-11D-A10S-08	5367804	19475090	229775531	2	7165										
CSMD2	114784	broad.mit.edu	37	chr1	34076828	34076828	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tggttgggctcggtggagaaGttcaggaactggatgtgagc	18	5	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:34076828G>C	uc001bxn.1	-	41	6065	c.6036C>G	c.(6034-6036)AAC>AAG	p.N2012K	CSMD2_uc001bxm.1_Missense_Mutation_p.N2052K|CSMD2_uc001bxo.1_Missense_Mutation_p.N925K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2012	CUB 12.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGGTGGAGAAGTTCAGGAACT	0.547													0	0	0	0.004007	0	15	30										C	34076828	G	C	34076828	3	2	26	1	0	0	0	0	1	0	0	0	3945	1020	36	4	4543	4	CSMD2	1	34076828	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	14601738	34076828	215173793	3	7166										
RIMS3	9783	broad.mit.edu	37	chr1	41101622	41101622	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gttgctgttggtgctcccatCggtggactcccggctgccct	13	14	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:41101622C>T	uc001cfu.1	-	4	794	c.325G>A	c.(325-327)GAT>AAT	p.D109N	RIMS3_uc001cfv.1_Missense_Mutation_p.D109N	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	109					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			GTGCTCCCATCGGTGGACTCC	0.682													0	0	0	0.01441	0	81	44										T	41101622	C	T	41101622	3	4	26	1	0	0	0	0	1	0	0	0	13369	884	31	1	621	1	RIMS3	1	41101622	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	7024794	41101622	208148999	4	7167										
GLIS1	148979	broad.mit.edu	37	chr1	53986418	53986418	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctcggtcaggacgtcggcctCggtgtcagggcccgcatgca	15	14	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:53986418C>T	uc001cvr.1	-	6	1657	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	364					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACGTCGGCCTCGGTGTCAGGG	0.662													0	0	0	0.001855	0	13	21										T	53986418	C	T	53986418	3	4	26	1	0	0	0	0	1	0	0	0	6445	893	31	1	792	1	GLIS1	1	53986418	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	12884796	53986418	195264203	5	7168										
TGFBR3	7049	broad.mit.edu	37	chr1	92185658	92185658	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	aaatatctgggaaaggaaacGgaaggcctccattttggcct	11	8	1	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:92185658G>A	uc001doh.2	-	9	1671	c.1205C>T	c.(1204-1206)CCG>CTG	p.P402L	TGFBR3_uc009wde.2_Missense_Mutation_p.P179L|TGFBR3_uc010osy.1_Missense_Mutation_p.P360L|TGFBR3_uc001doi.2_Missense_Mutation_p.P401L|TGFBR3_uc001doj.2_Missense_Mutation_p.P401L	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	402	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GAAAGGAAACGGAAGGCCTCC	0.572													0	0	0	0.01441	0	67	56										A	92185658	G	A	92185658	3	1	26	1	0	0	0	0	1	0	0	0	15820	1116	39	2	1386	2	TGFBR3	1	92185658	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	38199240	92185658	157064963	6	7169										
FLG	2312	broad.mit.edu	37	chr1	152279046	152279046	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gatgctgagtgcctggagctGtcttgtgcctgctcatggcg	15	10	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:152279046G>T	uc001ezu.1	-	3	8352	c.8316C>A	c.(8314-8316)GAC>GAA	p.D2772E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2772	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGGAGCTGTCTTGTGCCT	0.597									Ichthyosis				1	0	5.87652e-79	0.01441	6.81899e-79	168	560										T	152279046	G	T	152279046	3	4	26	1	0	0	0	0	1	0	0	0	5922	1368	48	4	3873	4	FLG	1	152279046	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	60093388	152279046	96971575	7	7170										
SLC39A1	27173	broad.mit.edu	37	chr1	153932939	153932939	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cagctccatggcccgagcccGgtctcgctgcagccctaccg	11	19	1	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:153932939G>A	uc001fdh.2	-	4	779	c.610C>T	c.(610-612)CGG>TGG	p.R204W	CRTC2_uc010ped.1_5'Flank|SLC39A1_uc001fdi.2_Missense_Mutation_p.R204W|SLC39A1_uc001fdj.2_Missense_Mutation_p.R204W|SLC39A1_uc001fdk.2_Missense_Mutation_p.R204W|SLC39A1_uc010pee.1_Missense_Mutation_p.R102W|SLC39A1_uc001fdl.2_Missense_Mutation_p.R204W	NM_014437	NP_055252	Q9NY26	S39A1_HUMAN	solute carrier family 39 (zinc transporter),	204	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		GCCCGAGCCCGGTCTCGCTGC	0.662													0	0	0	0.007835	0	41	35										A	153932939	G	A	153932939	3	1	26	1	0	0	0	0	1	0	0	0	14612	1115	39	2	368	2	SLC39A1	1	153932939	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	1653893	153932939	95317682	8	7171										
RXRG	6258	broad.mit.edu	37	chr1	165370612	165370612	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggcatttcaagccaatggaaCgcagagctgggaggcgcagc	15	10	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:165370612C>T	uc001gda.2	-	10	1580	c.1280G>A	c.(1279-1281)CGT>CAT	p.R427H		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	427	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GCCAATGGAACGCAGAGCTGG	0.602													0	0	0	0.00632	0	23	94										T	165370612	C	T	165370612	3	4	26	1	0	0	0	0	1	0	0	0	13765	536	19	2	115	2	RXRG	1	165370612	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	11437673	165370612	83880009	9	7172										
DNM3	26052	broad.mit.edu	37	chr1	172017754	172017754	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ttgctttcttaccttcaggaCagggttgtttactccagaca	8	10	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:172017754C>T	uc001gie.2	+	10	1375	c.1199C>T	c.(1198-1200)ACA>ATA	p.T400I	DNM3_uc001gid.3_Missense_Mutation_p.T400I|DNM3_uc009wwb.2_Missense_Mutation_p.T400I|DNM3_uc001gif.2_Missense_Mutation_p.T400I	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	400					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						ACCTTCAGGACAGGGTTGTTT	0.333													0	0	0	0.000602	0	5	25										T	172017754	C	T	172017754	3	4	26	1	0	0	0	0	1	0	0	0	4673	478	17	2	1237	2	DNM3	1	172017754	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	6647142	172017754	77232867	10	7173										
TNR	7143	broad.mit.edu	37	chr1	175355398	175355398	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ccacaaaagccacagtgtccGagacatcgcgaaccaggatc	9	14	0	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:175355398G>A	uc001gkp.1	-	6	1628	c.1547C>T	c.(1546-1548)TCG>TTG	p.S516L	TNR_uc009wwu.1_Missense_Mutation_p.S516L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	516	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CACAGTGTCCGAGACATCGCG	0.512													0	0	0	0.00245	0	12	57										A	175355398	G	A	175355398	3	1	26	1	0	0	0	0	1	0	0	0	16335	1059	37	1	2593	1	TNR	1	175355398	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	3337644	175355398	73895223	11	7174										
KIF21B	23046	broad.mit.edu	37	chr1	200968596	200968596	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cgtctcgctcttcctcctccTgggcaccaggcaccattggg	10	17	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:200968596T>C	uc001gvs.1	-	13	2085	c.1768_splice	c.e13-1	p.E590_splice	KIF21B_uc001gvr.1_Splice_Site_p.E590_splice|KIF21B_uc009wzl.1_Splice_Site_p.E590_splice|KIF21B_uc010ppn.1_Splice_Site_p.E590_splice	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TTCCTCCTCCTGGGCACCAGG	0.632													0	0	0	0.01441	0	95	35										C	200968596	T	C	200968596	5	2	26	1	0	0	0	0	0	0	1	0	8289	1594	55	5	3196	5	KIF21B	1	200968596	Splice_Site	SNP	T	TCGA-C4-A0F7-01A-11D-A10S-08	25613198	200968596	48282025	12	7175										
ACBD3	64746	broad.mit.edu	37	chr1	226340215	226340215	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gaacagtgaccacttctcctCggcccactgtaatcacggaa	8	14	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:226340215C>T	uc001hpy.2	-	7	1243	c.1196G>A	c.(1195-1197)CGA>CAA	p.R399Q		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	399	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		CACTTCTCCTCGGCCCACTGT	0.463													0	0	0	0.01441	0	135	225										T	226340215	C	T	226340215	3	4	26	1	0	0	0	0	1	0	0	0	123	884	31	1	398	1	ACBD3	1	226340215	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	25371619	226340215	22910406	13	7176			1	22		2	2	15	C		4.070115e-05
ACBD3	64746	broad.mit.edu	37	chr1	226340229	226340229	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tctcctcggcccactgtaatCacggaatctgcatcctgctg	8	15	3	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr1:226340229C>T	uc001hpy.2	-	7	1229	c.1182G>A	c.(1180-1182)GTG>GTA	p.V394V		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	394	GOLD.			KEKIQQDADSVITV -> QREDSAGCRFRDYS (in Ref. 2).	steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		CCACTGTAATCACGGAATCTG	0.453													0	0	0	0.01441	0	141	249										T	226340229	C	T	226340229	2	4	26	1	0	0	0	0	0	0	0	1	123	813	29	1		1	ACBD3	1	226340229	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	14	226340229	22910392	14	7177			1	22		2	2	15	C		4.070115e-05
MYT1L	23040	broad.mit.edu	37	chr2	1983502	1983502	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	agcgcggacatacctcgaacCcctttggaccgcgtgcgatg	12	14	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr2:1983502C>T	uc002qxe.2	-	6	875	c.48G>A	c.(46-48)GGG>GGA	p.G16G	MYT1L_uc002qxd.2_Silent_p.G16G|MYT1L_uc002qxf.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	16					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TACCTCGAACCCCTTTGGACC	0.597													0	0	0	0.006214	0	9	65										T	1983502	C	T	1983502	2	4	26	1	0	0	0	0	0	0	0	1	10107	610	22	2		2	MYT1L	2	1983502	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		1983502	241215871	15	7178										
CDKL4	344387	broad.mit.edu	37	chr2	39417450	39417453	+	Frame_Shift_Del	DEL	TGTT	TGTT	-													0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	aaaatgcaattcatacctagTgttctgattatcagataaag							TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr2:39417450_39417453delTGTT	uc002rrm.2	-	5	645_648	c.645_648delAACA	c.(643-648)AGAACAfs	p.R215fs	CDKL4_uc010fal.1_Frame_Shift_Del_p.R215fs	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4	215_216	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				TCATACCTAGTGTTCTGATTATCA	0.343																		25	96	---	---								-	39417453	TGTT	-	39417450	7	5	26	1	0	1	0	1	0	0	0	0	3156	1683	59	0	315	0	CDKL4	2	39417450	Frame_Shift_Del	DEL	TGTT	TCGA-C4-A0F7-01A-11D-A10S-08	37433948	39417450	203781923	16	7179										
CTNNA2	1496	broad.mit.edu	37	chr2	79971689	79971689	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gaagagttggtggctgctgtAgaggatgtgcgcaaacaagg	17	5	0	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr2:79971689A>T	uc010ysh.1	+	2	284	c.279A>T	c.(277-279)GTA>GTT	p.V93V	CTNNA2_uc010yse.1_Silent_p.V93V|CTNNA2_uc010ysf.1_Silent_p.V93V|CTNNA2_uc010ysg.1_Silent_p.V93V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	93					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TGGCTGCTGTAGAGGATGTGC	0.428													0	0	0	0.012319	0	22	16										T	79971689	A	T	79971689	2	4	26	1	0	0	0	0	0	0	0	1	4013	407	15	5		5	CTNNA2	2	79971689	Silent	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08	40554239	79971689	163227684	17	7180										
DNAH7	56171	broad.mit.edu	37	chr2	196865506	196865506	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	acgtcataaacatttagaaaGatatctatatagtcactcaa	4	7	4	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr2:196865506G>A	uc002utj.3	-	12	1376	c.1275C>T	c.(1273-1275)ATC>ATT	p.I425I		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	425	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CATTTAGAAAGATATCTATAT	0.343													0	0	0	0.01441	0	158	150										A	196865506	G	A	196865506	2	1	26	1	0	0	0	0	0	0	0	1	4606	932	33	1		1	DNAH7	2	196865506	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	116893817	196865506	46333867	18	7181										
IKZF2	22807	broad.mit.edu	37	chr2	213872344	213872344	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggtagtatccaaagctttgaCatcctccttcatgtaagctg	8	10	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr2:213872344C>A	uc002vem.2	-	8	1490	c.1321G>T	c.(1321-1323)GTC>TTC	p.V441F	IKZF2_uc010fuu.2_Missense_Mutation_p.V296F|IKZF2_uc002vej.2_Missense_Mutation_p.V388F|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.V367F|IKZF2_uc002vel.2_Missense_Mutation_p.V362F|IKZF2_uc010fuw.2_Missense_Mutation_p.V215F|IKZF2_uc010fux.2_Missense_Mutation_p.V215F|IKZF2_uc010fuy.2_Missense_Mutation_p.V369F|IKZF2_uc002ven.2_Missense_Mutation_p.V415F|IKZF2_uc002vei.2_Missense_Mutation_p.V219F	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		AAAGCTTTGACATCCTCCTTC	0.483													1	0	1.12685e-05	0.004482	1.18464e-05	9	63										A	213872344	C	A	213872344	3	1	26	1	0	0	0	0	1	0	0	0	7615	478	17	4	263	4	IKZF2	2	213872344	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	17006838	213872344	29327029	19	7182										
HRH1	3269	broad.mit.edu	37	chr3	11301151	11301151	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	taagtatcgtaccaagacccGagcctcggccaccattctgg	9	14	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:11301151G>A	uc010hdr.2	+	2	770	c.428G>A	c.(427-429)CGA>CAA	p.R143Q	HRH1_uc010hds.2_Missense_Mutation_p.R143Q|HRH1_uc010hdt.2_Missense_Mutation_p.R143Q|HRH1_uc003bwb.3_Missense_Mutation_p.R143Q	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	143	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	ACCAAGACCCGAGCCTCGGCC	0.552													0	0	0	0.01441	0	51	187										A	11301151	G	A	11301151	3	1	26	1	0	0	0	0	1	0	0	0	7355	1058	37	1	430	1	HRH1	3	11301151	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		11301151	186721279	20	7183										
PRKCD	5580	broad.mit.edu	37	chr3	53213624	53213624	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	acactggtgcagaagaagccGaccatgtatcctgagtggaa	12	9	0	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:53213624G>A	uc003dgl.2	+	4	500	c.147G>A	c.(145-147)CCG>CCA	p.P49P	PRKCD_uc003dgm.2_Silent_p.P49P|PRKCD_uc003dgn.2_Silent_p.P49P	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	49	C2.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AGAAGAAGCCGACCATGTATC	0.592													0	0	0	0.010504	0	20	43										A	53213624	G	A	53213624	2	1	26	1	0	0	0	0	0	0	0	1	12509	1045	37	1		1	PRKCD	3	53213624	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	41912473	53213624	144808806	21	7184										
ATXN7	6314	broad.mit.edu	37	chr3	63985136	63985136	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tttttgaaagccaaaggcacGtccctgacagctgaaaatag	9	9	0	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:63985136G>A	uc003dlw.3	+	13	3225	c.2672G>A	c.(2671-2673)CGT>CAT	p.R891H	ATXN7_uc010hnv.2_Silent_p.T913T|ATXN7_uc011bfn.1_Missense_Mutation_p.R746H	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	891				PKARP -> VGNGL (in Ref. 2; AAC39765/ AAC19163).	cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CCAAAGGCACGTCCCTGACAG	0.448													0	0	0	0.00499	0	16	26										A	63985136	G	A	63985136	3	1	26	1	0	0	0	0	1	0	0	0	1215	1145	40	2	2853	2	ATXN7	3	63985136	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	10771512	63985136	134037294	22	7185										
CD200	4345	broad.mit.edu	37	chr3	112054803	112054803	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	accacagactctgaccaggaCaattgggggccctctcctta	9	14	2	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:112054803C>A	uc003dyw.2	+	2	170	c.26C>A	c.(25-27)ACA>AAA	p.T9K	CD200_uc010hqd.1_Intron|CD200_uc003dyx.2_Intron|CD200_uc003dyy.2_Intron|CD200_uc003dyz.2_Intron	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	Error:Variant_position_missing_in_P41217_after_alignment					regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				CTGACCAGGACAATTGGGGGC	0.274													1	0	8.58068e-18	0.007291	9.42343e-18	27	116										A	112054803	C	A	112054803	3	1	26	1	0	0	0	0	1	0	0	0	2980	478	17	4	32	4	CD200	3	112054803	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	48069667	112054803	85967627	23	7186										
C3orf30	152405	broad.mit.edu	37	chr3	118865565	118865565	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctgaccagagaggttccagaCagaccgaccacagaatggca	11	12	0	5			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:118865565C>G	uc003ecb.1	+	1	569	c.529C>G	c.(529-531)CAG>GAG	p.Q177E	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.Q177E	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	177										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		AGGTTCCAGACAGACCGACCA	0.527													0	0	0	0.01441	0	38	79										G	118865565	C	G	118865565	3	3	26	1	0	0	0	0	1	0	0	0	2220	479	17	4	531	4	C3orf30	3	118865565	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	6810762	118865565	79156865	24	7187										
SI	6476	broad.mit.edu	37	chr3	164786928	164786928	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tatcaacgaagaagcaccaaGgaataagagagtcattccac	8	9	2	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:164786928G>C	uc003fei.2	-	4	373	c.311C>G	c.(310-312)CCT>CGT	p.P104R		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	104	Lumenal.|P-type 1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GAAGCACCAAGGAATAAGAGA	0.343										HNSCC(35;0.089)			0	0	0	0.012213	0	34	71										C	164786928	G	C	164786928	3	2	26	1	0	0	0	0	1	0	0	0	14297	1000	35	4	5352	4	SI	3	164786928	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	45921363	164786928	33235502	25	7188										
EIF4A2	1974	broad.mit.edu	37	chr3	186501413	186501413	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tcggatcatgtctggtggctCcgcggattataacaggtatg	13	8	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:186501413C>T	uc003fqs.2	+	1	53	c.14C>T	c.(13-15)TCC>TTC	p.S5F	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Missense_Mutation_p.S5F|EIF4A2_uc003fqv.2_5'UTR|EIF4A2_uc003fqw.2_5'UTR|SNORD2_uc010hyu.1_5'Flank|EIF4A2_uc011bsb.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	5					interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TCTGGTGGCTCCGCGGATTAT	0.562			T	BCL6	NHL								0	0	0	0.01441	0	81	184										T	186501413	C	T	186501413	3	4	26	1	0	0	0	0	1	0	0	0	5025	855	30	1	16	1	EIF4A2	3	186501413	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	21714485	186501413	11521017	26	7189										
MUC4	4585	broad.mit.edu	37	chr3	195511815	195511815	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gtggatgctgaggaagggctGgtgacaggaagaggggtggc	22	4	0	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr3:195511815G>A	uc011bto.1	-	2	7096	c.6636C>T	c.(6634-6636)ACC>ACT	p.T2212T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGGGCTGGTGACAGGAA	0.602													0	0	0	0.004672	0	3	5										A	195511815	G	A	195511815	2	1	26	1	0	0	0	0	0	0	0	1	9978	1335	47	2		2	MUC4	3	195511815	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	9010402	195511815	2510615	27	7190										
RGS12	6002	broad.mit.edu	37	chr4	3425321	3425321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tcacggaggtgctgcggcccGtggtggccagatacggcctg	17	12	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr4:3425321G>A	uc003ggw.2	+	13	4091	c.3187G>A	c.(3187-3189)GTG>ATG	p.V1063M	RGS12_uc003ggv.2_Missense_Mutation_p.V1063M|RGS12_uc003ggy.1_Missense_Mutation_p.V461M|RGS12_uc003ggz.2_Missense_Mutation_p.V415M|RGS12_uc010icu.1_Missense_Mutation_p.V262M|RGS12_uc011bvs.1_Missense_Mutation_p.V405M|RGS12_uc003gha.2_Missense_Mutation_p.V405M|RGS12_uc010icv.2_Missense_Mutation_p.V262M|RGS12_uc003ghb.2_Missense_Mutation_p.V262M	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1063	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCTGCGGCCCGTGGTGGCCAG	0.632													0	0	0	0.004289	0	35	93										A	3425321	G	A	3425321	3	1	26	1	0	0	0	0	1	0	0	0	13295	1145	40	2	3291	2	RGS12	4	3425321	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		3425321	187728955	28	7191										
TMPRSS11F	389208	broad.mit.edu	37	chr4	68964665	68964665	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tatgattgctacaattgctaAtgtgaaaagagctagccgta	9	6	0	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr4:68964665A>G	uc003hdt.1	-	2	152	c.103T>C	c.(103-105)TTA>CTA	p.L35L		NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	35	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ACAATTGCTAATGTGAAAAGA	0.388													0	0	0	0.004672	0	3	14										G	68964665	A	G	68964665	2	3	26	1	0	0	0	0	0	0	0	1	16240	98	4	5		5	TMPRSS11F	4	68964665	Silent	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08	65539344	68964665	122189611	29	7192										
FRAS1	80144	broad.mit.edu	37	chr4	79429990	79429990	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tctgtgtcaccccctgcgacCctcatttccccagatacgct	6	18	3	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr4:79429990C>T	uc003hlb.2	+	63	10050	c.9610C>T	c.(9610-9612)CCT>TCT	p.P3204S	FRAS1_uc003hlc.1_Missense_Mutation_p.P206S	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3199	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CCCCTGCGACCCTCATTTCCC	0.567													0	0	0	0.008291	0	11	15										T	79429990	C	T	79429990	3	4	26	1	0	0	0	0	1	0	0	0	6042	623	22	2	9935	2	FRAS1	4	79429990	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	10465325	79429990	111724286	30	7193										
RG9MTD2	93587	broad.mit.edu	37	chr4	100479211	100479211	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	aatgattcatgatacctttaAtaccatcaagtgatcaaaac	4	8	3	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr4:100479211A>G	uc003huy.2	-	3	656	c.343T>C	c.(343-345)TTA>CTA	p.L115L	RG9MTD2_uc003huz.3_Silent_p.L115L|RG9MTD2_uc003hva.3_Silent_p.L115L	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	115							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		GATACCTTTAATACCATCAAG	0.328													0	0	0	0.001855	0	10	18										G	100479211	A	G	100479211	2	3	26	1	0	0	0	0	0	0	0	1	13272	98	4	5		5	RG9MTD2	4	100479211	Silent	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08	21049221	100479211	90675065	31	7194										
UGT8	7368	broad.mit.edu	37	chr4	115597250	115597250	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	agtattttttactggatattGcctttgtgcttttgcttggt	9	5	0	0	rs77695673		TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr4:115597250G>T	uc003ibs.2	+	6	1954	c.1432G>T	c.(1432-1434)GCC>TCC	p.A478S	UGT8_uc003ibt.2_Missense_Mutation_p.A478S|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	478	Helical; (Potential).				central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		ACTGGATATTGCCTTTGTGCT	0.373													1	0	7.34454e-26	0.01441	8.28788e-26	50	83										T	115597250	G	T	115597250	3	4	26	1	0	0	0	0	1	0	0	0	16962	1319	46	4	1450	4	UGT8	4	115597250	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	15118039	115597250	75557026	32	7195										
IRX4	50805	broad.mit.edu	37	chr5	1879669	1879671	+	In_Frame_Del	DEL	CCT	CCT	-													0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ccgcgcctcctcctcgccccCctcctcctcctcgccctccg							TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr5:1879669_1879671delCCT	uc003jcz.2	-	4	802_804	c.683_685delAGG	c.(682-687)GAGGGG>GGG	p.E228del	IRX4_uc011cmf.1_In_Frame_Del_p.E89del	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	228	Poly-Glu.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		tcctcgcccccctcctcctcctc	0.507																		7	141	---	---								-	1879671	CCT	-	1879669	7	5	26	1	0	1	0	1	0	0	0	0	7846	623	22	0	882	0	IRX4	5	1879669	In_Frame_Del	DEL	CCT	TCGA-C4-A0F7-01A-11D-A10S-08		1879669	179035591	33	7196										
SRD5A1	6715	broad.mit.edu	37	chr5	6633926	6633926	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	agcgagtccgccccgcgtctCcgcagcgcgcccaactgcat	11	19	1	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr5:6633926C>T	uc003jdw.2	+	1	427	c.237C>T	c.(235-237)CTC>CTT	p.L79L	NSUN2_uc003jdu.2_5'Flank|NSUN2_uc011cmk.1_5'Flank|NSUN2_uc003jdv.2_5'Flank|SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.S88F	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	79					androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	CCCCGCGTCTCCGCAGCGCGC	0.736													0	0	0	0.006122	0	16	157										T	6633926	C	T	6633926	2	4	26	1	0	0	0	0	0	0	0	1	15137	842	30	1		1	SRD5A1	5	6633926	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	4754257	6633926	174281334	34	7197										
MARVELD2	153562	broad.mit.edu	37	chr5	68737477	68737477	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ttgggatgtacaaggttattCttaacgcttatttgaaacca	8	6	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr5:68737477C>G	uc003jwq.2	+	7	1732	c.1673C>G	c.(1672-1674)TCT>TGT	p.S558C	MARVELD2_uc010ixf.2_Missense_Mutation_p.S546C|MARVELD2_uc003jwr.1_Intron|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	558	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		CAAGGTTATTCTTAACGCTTA	0.179													0	0	0	0.004656	0	24	34										G	68737477	C	G	68737477	3	3	26	1	0	0	0	0	1	0	0	0	9318	913	32	1	1695	1	MARVELD2	5	68737477	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	62103551	68737477	112177783	35	7198										
PDGFRB	5159	broad.mit.edu	37	chr5	149515232	149515232	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gaggttggtcagtgtgagcaCgctggagaaggtgccatcct	16	8	1	2	rs80162387	by1000genomes	TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr5:149515232C>T	uc003lro.2	-	3	719	c.250G>A	c.(250-252)GTG>ATG	p.V84M	PDGFRB_uc010jhd.2_Translation_Start_Site|PDGFRB_uc011dcg.1_Missense_Mutation_p.V84M	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	84	Extracellular (Potential).|Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	AGTGTGAGCACGCTGGAGAAG	0.597			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								0	0	0	0.004482	0	8	102										T	149515232	C	T	149515232	3	4	26	1	0	0	0	0	1	0	0	0	11662	536	19	2	3154	2	PDGFRB	5	149515232	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	80777755	149515232	31400028	36	7199										
FAM136B	387071	broad.mit.edu	37	chr6	3045879	3045879	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggtgcaccatgcattgcaatGacaaagccaaagattcaata	8	9	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:3045879G>A	uc011dhr.1	+	1	262	c.262G>A	c.(262-264)GAC>AAC	p.D88N		NM_001012983	NP_001013001			hypothetical protein LOC387071												0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				GCATTGCAATGACAAAGCCAA	0.547													0	0	0	0.009718	0	41	106										A	3045879	G	A	3045879	3	1	26	1	0	0	0	0	1	0	0	0	5451	1290	45	1	264	1	FAM136B	6	3045879	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		3045879	168069188	37	7200										
KIF13A	63971	broad.mit.edu	37	chr6	17777555	17777555	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cctccgaatgtgccgggcttTggtggaaagtgcttctttga	13	9	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:17777555T>C	uc003ncg.3	-	34	4228	c.4123A>G	c.(4123-4125)AAA>GAA	p.K1375E	KIF13A_uc003ncf.2_Missense_Mutation_p.K1362E|KIF13A_uc003nch.3_Missense_Mutation_p.K1375E|KIF13A_uc003nci.3_Missense_Mutation_p.K1362E|KIF13A_uc003nce.1_5'UTR	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1375					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TGCCGGGCTTTGGTGGAAAGT	0.368													0	0	0	0.010729	0	10	33										C	17777555	T	C	17777555	3	2	26	1	0	0	0	0	1	0	0	0	8274	1821	63	5	1343	5	KIF13A	6	17777555	Missense_Mutation	SNP	T	TCGA-C4-A0F7-01A-11D-A10S-08	14731676	17777555	153337512	38	7201										
CUL9	23113	broad.mit.edu	37	chr6	43156294	43156294	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cttgcggggtcccggtcctcGcagctccctggatcagcatg	13	15	1	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:43156294G>A	uc003ouk.2	+	8	2096	c.2021G>A	c.(2020-2022)CGC>CAC	p.R674H	CUL9_uc003ouj.1_3'UTR|CUL9_uc003oul.2_Missense_Mutation_p.R674H|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_3'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	674					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCCGGTCCTCGCAGCTCCCTG	0.542													0	0	0	0.01441	0	53	43										A	43156294	G	A	43156294	3	1	26	1	0	0	0	0	1	0	0	0	4061	1087	38	2	2047	2	CUL9	6	43156294	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	25378739	43156294	127958773	39	7202										
HSP90AB1	3326	broad.mit.edu	37	chr6	44216418	44216418	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	aggtggagacttttgcctttCaggcagaaattgcccaactc	10	10	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:44216418C>T	uc003oxa.1	+	2	136	c.52C>T	c.(52-54)CAG>TAG	p.Q18*	HSP90AB1_uc011dvr.1_Nonsense_Mutation_p.Q18*|HSP90AB1_uc003oxb.1_Nonsense_Mutation_p.Q18*|HSP90AB1_uc011dvs.1_5'UTR|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	18					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding	p.Q18*(1)		lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTTTGCCTTTCAGGCAGAAAT	0.423													0	0	0	0.01441	0	91	209										T	44216418	C	T	44216418	4	4	26	1	0	0	0	0	0	1	0	0	7402	827	29	1	54	1	HSP90AB1	6	44216418	Nonsense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	1060124	44216418	126898649	40	7203										
ME1	4199	broad.mit.edu	37	chr6	83963391	83963391	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	caatactggtttcgatacttGttcaggagacgaaatgcatt	9	7	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:83963391G>T	uc003pjy.2	-	7	877	c.771C>A	c.(769-771)AAC>AAA	p.N257K	ME1_uc011dzb.1_Missense_Mutation_p.N182K|ME1_uc011dzc.1_Missense_Mutation_p.N91K	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	257					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TTCGATACTTGTTCAGGAGAC	0.328													1	0	2.00529e-23	0.00333	2.22208e-23	21	89										T	83963391	G	T	83963391	3	4	26	1	0	0	0	0	1	0	0	0	9417	1368	48	4	979	4	ME1	6	83963391	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	39746973	83963391	87151676	41	7204										
AKD1	221264	broad.mit.edu	37	chr6	109980580	109980580	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cgtattattgtgctgtctttGcccagaaattctctggcaca	8	10	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:109980580G>A	uc003ptn.2	-	7	558	c.481C>T	c.(481-483)CAA>TAA	p.Q161*	AKD1_uc003ptr.3_Nonsense_Mutation_p.Q161*|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	161					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TGCTGTCTTTGCCCAGAAATT	0.303													0	0	0	0.00623	0	35	39										A	109980580	G	A	109980580	4	1	26	1	0	0	0	0	0	1	0	0	460	1328	46	2	5406	2	AKD1	6	109980580	Nonsense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	26017189	109980580	61134487	42	7205										
GPR126	57211	broad.mit.edu	37	chr6	142691909	142691909	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tcccaaacctagctctgaaaGctgaaagcaacctaagctgt	7	12	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:142691909G>C	uc010khc.2	+	4	1459	c.1048G>C	c.(1048-1050)GCT>CCT	p.A350P	GPR126_uc010khd.2_Missense_Mutation_p.A350P|GPR126_uc010khe.2_Missense_Mutation_p.A350P|GPR126_uc010khf.2_Missense_Mutation_p.A350P|GPR126_uc003qix.2_Missense_Mutation_p.A350P	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	350	Pentaxin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AGCTCTGAAAGCTGAAAGCAA	0.358													0	0	0	0.009096	0	3	48										C	142691909	G	C	142691909	3	2	26	1	0	0	0	0	1	0	0	0	6640	971	34	4	1062	4	GPR126	6	142691909	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	32711329	142691909	28423158	43	7206										
TAB2	23118	broad.mit.edu	37	chr6	149700178	149700178	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	agctgccagccccccaaataCggatgagctgatgtcccgta	10	14	0	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr6:149700178C>T	uc003qmj.2	+	3	1305	c.1127C>T	c.(1126-1128)ACG>ATG	p.T376M	TAB2_uc011eec.1_Missense_Mutation_p.T344M|TAB2_uc010kia.1_Missense_Mutation_p.T376M|TAB2_uc010kib.1_Missense_Mutation_p.T376M|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	376					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						CCCCCAAATACGGATGAGCTG	0.493													0	0	0	0.00333	0	26	60										T	149700178	C	T	149700178	3	4	26	1	0	0	0	0	1	0	0	0	15493	536	19	2	1133	2	TAB2	6	149700178	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	7008269	149700178	21414889	44	7207										
FOXK1	221937	broad.mit.edu	37	chr7	4794201	4794201	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gcagagtttgcagcaaaggcCgcgtcggagcagcaggcaga	16	10	0	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr7:4794201C>T	uc003snc.1	+	3	868	c.858C>T	c.(856-858)GCC>GCT	p.A286A	FOXK1_uc003sna.1_Silent_p.A123A|FOXK1_uc003snb.1_Silent_p.A286A	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	286					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		CAGCAAAGGCCGCGTCGGAGC	0.657													0	0	0	0.010729	0	11	59										T	4794201	C	T	4794201	2	4	26	1	0	0	0	0	0	0	0	1	6014	639	23	2		2	FOXK1	7	4794201	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		4794201	154344462	45	7208										
DNAH11	8701	broad.mit.edu	37	chr7	21826264	21826264	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	caacctcagtgagctgaaagCctttcccaaccctcccatcg	6	17	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr7:21826264C>G	uc003svc.2	+	60	9672	c.9641C>G	c.(9640-9642)GCC>GGC	p.A3214G		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3214	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GAGCTGAAAGCCTTTCCCAAC	0.512									Kartagener_syndrome				0	0	0	0.006214	0	9	96										G	21826264	C	G	21826264	3	3	26	1	0	0	0	0	1	0	0	0	4599	739	26	4	9876	4	DNAH11	7	21826264	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	17032063	21826264	137312399	46	7209										
HECW1	23072	broad.mit.edu	37	chr7	43484652	43484652	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gagggggctactccaggcacGgcgcaccctggccactccgg	15	16	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr7:43484652G>A	uc003tid.1	+	11	2486	c.1881G>A	c.(1879-1881)ACG>ACA	p.T627T	HECW1_uc011kbi.1_Silent_p.T627T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	627					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTCCAGGCACGGCGCACCCTG	0.706													0	0	0	0.008291	0	11	20										A	43484652	G	A	43484652	2	1	26	1	0	0	0	0	0	0	0	1	7042	1103	39	2		2	HECW1	7	43484652	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	21658388	43484652	115654011	47	7210										
FBXO24	26261	broad.mit.edu	37	chr7	100187841	100187841	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ccagtcagagaccttgttgcCctcggccagacctgccgcta	10	16	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr7:100187841C>G	uc003uvm.1	+	3	476	c.183C>G	c.(181-183)GCC>GCG	p.A61A	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Silent_p.A61A|FBXO24_uc003uvn.1_Intron|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Silent_p.A99A|FBXO24_uc011kka.1_Silent_p.A49A	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	61	F-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ACCTTGTTGCCCTCGGCCAGA	0.607													0	0	0	0.01441	0	64	31										G	100187841	C	G	100187841	2	3	26	1	0	0	0	0	0	0	0	1	5735	610	22	4		4	FBXO24	7	100187841	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	56703189	100187841	58950822	48	7211										
ACHE	43	broad.mit.edu	37	chr7	100491616	100491616	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	aggctgcttgggctccggtgGcagaaagcgacggggtccca	17	11	0	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr7:100491616G>A	uc003uxd.2	-	1	394	c.238C>T	c.(238-240)CCA>TCA	p.P80S	ACHE_uc003uxe.2_Missense_Mutation_p.P80S|ACHE_uc003uxf.2_Missense_Mutation_p.P80S|ACHE_uc003uxg.2_Missense_Mutation_p.P80S|ACHE_uc003uxh.2_Missense_Mutation_p.P80S|ACHE_uc003uxi.2_Missense_Mutation_p.P80S|ACHE_uc003uxj.1_Missense_Mutation_p.P199S	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	80					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GGCTCCGGTGGCAGAAAGCGA	0.627													0	0	0	0.005443	0	28	146										A	100491616	G	A	100491616	3	1	26	1	0	0	0	0	1	0	0	0	141	1203	42	2	1757	2	ACHE	7	100491616	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	303775	100491616	58647047	49	7212										
ORAI2	80228	broad.mit.edu	37	chr7	102087006	102087006	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gacgcagtaccagtacccgcGgccgctgctgattgccttca	11	15	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr7:102087006G>A	uc010lhz.1	+	4	507	c.272G>A	c.(271-273)CGG>CAG	p.R91Q	ORAI2_uc003uzj.2_Missense_Mutation_p.R91Q|ORAI2_uc003uzk.2_Missense_Mutation_p.R91Q|ORAI2_uc011kks.1_Missense_Mutation_p.R14Q	NM_001126340	NP_001119812	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator	91						integral to membrane	protein binding			ovary(1)|kidney(1)	2						CAGTACCCGCGGCCGCTGCTG	0.662													0	0	0	0.014323	0	17	72										A	102087006	G	A	102087006	3	1	26	1	0	0	0	0	1	0	0	0	11258	1116	39	2	278	2	ORAI2	7	102087006	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	1595390	102087006	57051657	50	7213										
DDHD2	23259	broad.mit.edu	37	chr8	38095117	38095117	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gaaactggaatctcccaacaGagaaattattattttacaca	5	8	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr8:38095117G>A	uc003xlb.2	+	4	850	c.473G>A	c.(472-474)AGA>AAA	p.R158K	DDHD2_uc003xla.2_Missense_Mutation_p.R158K|DDHD2_uc003xlc.2_Missense_Mutation_p.R158K|DDHD2_uc011lbl.1_Silent_p.Q10Q	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	158					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TCTCCCAACAGAGAAATTATT	0.333													0	0	0	0.006122	0	16	57										A	38095117	G	A	38095117	3	1	26	1	0	0	0	0	1	0	0	0	4327	942	33	1	483	1	DDHD2	8	38095117	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		38095117	108268905	51	7214										
KCNB2	9312	broad.mit.edu	37	chr8	73480335	73480335	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gcactttcgtttggccaagaActtgattactgggggattga	12	7	0	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr8:73480335A>G	uc003xzb.2	+	2	954	c.366A>G	c.(364-366)GAA>GAG	p.E122E		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	122	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTGGCCAAGAACTTGATTACT	0.448													0	0	0	0.004878	0	37	120										G	73480335	A	G	73480335	2	3	26	1	0	0	0	0	0	0	0	1	8013	40	2	5		5	KCNB2	8	73480335	Silent	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08	35385218	73480335	72883687	52	7215										
ZFHX4	79776	broad.mit.edu	37	chr8	77776411	77776411	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	agaaatgccaaagagcatgtTagattattacctcactcagt	7	8	2	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr8:77776411T>C	uc003yav.2	+	11	10713	c.10326T>C	c.(10324-10326)GTT>GTC	p.V3442V		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3438						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAGAGCATGTTAGATTATTAC	0.433										HNSCC(33;0.089)			0	0	0	0.001168	0	6	24										C	77776411	T	C	77776411	2	2	26	1	0	0	0	0	0	0	0	1	17632	1741	61	5		5	ZFHX4	8	77776411	Silent	SNP	T	TCGA-C4-A0F7-01A-11D-A10S-08	4296076	77776411	68587611	53	7216										
POU5F1B	5462	broad.mit.edu	37	chr8	128429170	128429170	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gtctccgtcatcactctgggCtctcccatgcattcaaactg	7	15	6	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr8:128429170C>T	uc003ysf.2	+	1	1314	c.1059C>T	c.(1057-1059)GGC>GGT	p.G353G	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_5'Flank	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	353						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCACTCTGGGCTCTCCCATGC	0.577													0	0	0	0.001855	0	12	14										T	128429170	C	T	128429170	2	4	26	1	0	0	0	0	0	0	0	1	12282	784	28	2		2	POU5F1B	8	128429170	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	50652759	128429170	17934852	54	7217										
SETX	23064	broad.mit.edu	37	chr9	135205856	135205856	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	atacatgttaggacaataatCtgggcaaatggctgttctcc	9	8	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr9:135205856C>A	uc004cbk.2	-	10	1312	c.1129G>T	c.(1129-1131)GAT>TAT	p.D377Y	SETX_uc004cbj.2_5'UTR|SETX_uc010mzt.2_5'UTR	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	377					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GGACAATAATCTGGGCAAATG	0.388													1	0	1.68575e-08	0.007291	1.78748e-08	29	14										A	135205856	C	A	135205856	3	1	26	1	0	0	0	0	1	0	0	0	14141	913	32	3	6972	3	SETX	9	135205856	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		135205856	6007575	55	7218										
TAF5	6877	broad.mit.edu	37	chr10	105133276	105133277	+	Frame_Shift_Ins	INS	-	-	A													0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	agagttgtcccaacttttttINSatcctctgtttgtgcacatg							TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr10:105133276_105133277insA	uc001kwv.2	+	2	744_745	c.721_722insA	c.(721-723)TATfs	p.Y241fs	TAF5_uc010qqq.1_Frame_Shift_Ins_p.Y241fs	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	241					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CCAACTTTTTTATCCTCTGTTT	0.371																		105	165	---	---								A	105133277	-	A	105133276	7	5	26	1	0	1	1	0	0	0	0	0	15525	1754	61	0	727	0	TAF5	10	105133276	Frame_Shift_Ins	INS	-	TCGA-C4-A0F7-01A-11D-A10S-08		105133276	30401471	56	7219										
PHRF1	57661	broad.mit.edu	37	chr11	607297	607297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ccctggggcggttcaggctcGgaacttgtcaaatgggagtg	16	9	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr11:607297G>A	uc001lqe.2	+	14	1972	c.1841G>A	c.(1840-1842)CGG>CAG	p.R614Q	PHRF1_uc010qwc.1_Missense_Mutation_p.R613Q|PHRF1_uc010qwd.1_Missense_Mutation_p.R612Q|PHRF1_uc010qwe.1_Missense_Mutation_p.R610Q|PHRF1_uc009ybz.1_Missense_Mutation_p.R404Q|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	614							RNA polymerase binding|zinc ion binding				0						GTTCAGGCTCGGAACTTGTCA	0.667													0	0	0	0.01441	0	44	137										A	607297	G	A	607297	3	1	26	1	0	0	0	0	1	0	0	0	11861	1116	39	2	1888	2	PHRF1	11	607297	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		607297	134399219	57	7220										
PLCB3	5331	broad.mit.edu	37	chr11	64035013	64035013	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gactcggagagccaggaggaGaacacgcagctctgaactgg	15	10	1	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr11:64035013G>A	uc001nzb.2	+	31	3690	c.3690G>A	c.(3688-3690)GAG>GAA	p.E1230E	PLCB3_uc009ypg.1_Silent_p.E1230E|PLCB3_uc009yph.1_Silent_p.E1163E|PLCB3_uc009ypi.2_Silent_p.E1230E|GPR137_uc009ypj.1_5'Flank	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1230					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GCCAGGAGGAGAACACGCAGC	0.652													0	0	0	0.004482	0	8	3										A	64035013	G	A	64035013	2	1	26	1	0	0	0	0	0	0	0	1	12029	933	33	1		1	PLCB3	11	64035013	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	63427716	64035013	70971503	58	7221										
PYGM	5837	broad.mit.edu	37	chr11	64525784	64525784	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cgaatcccgtagccataggcGgccaggcccagtgttgccat	12	14	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr11:64525784G>A	uc001oax.3	-	4	1279	c.462C>T	c.(460-462)GCC>GCT	p.A154A	PYGM_uc001oay.3_Intron	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	154					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	AGCCATAGGCGGCCAGGCCCA	0.602													0	0	0	0.01441	0	122	42										A	64525784	G	A	64525784	2	1	26	1	0	0	0	0	0	0	0	1	12862	1103	39	2		2	PYGM	11	64525784	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	490771	64525784	70480732	59	7222										
ANKRD49	54851	broad.mit.edu	37	chr11	94231644	94231644	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gccaggaggacaagtatctaTcactacctctttgaaattgt	8	9	3	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr11:94231644T>C	uc001pew.2	+	3	805	c.666T>C	c.(664-666)TAT>TAC	p.Y222Y	ANKRD49_uc001pex.2_3'UTR|ANKRD49_uc001pey.2_RNA	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	222					positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAAGTATCTATCACTACCTCT	0.398													0	0	0	0.011902	0	41	64										C	94231644	T	C	94231644	2	2	26	1	0	0	0	0	0	0	0	1	675	1442	50	5		5	ANKRD49	11	94231644	Silent	SNP	T	TCGA-C4-A0F7-01A-11D-A10S-08	29705860	94231644	40774872	60	7223										
PPP2R1B	5519	broad.mit.edu	37	chr11	111614171	111614171	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cattactaacactttgggaaCaatagtattttgggcccact	7	9	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr11:111614171C>T	uc001plx.1	-	12	1567	c.1483G>A	c.(1483-1485)GTT>ATT	p.V495I	PPP2R1B_uc001plw.1_Missense_Mutation_p.V495I|PPP2R1B_uc010rwi.1_Missense_Mutation_p.V431I|PPP2R1B_uc010rwj.1_Missense_Mutation_p.V334I|PPP2R1B_uc010rwk.1_Missense_Mutation_p.V450I|PPP2R1B_uc010rwl.1_Missense_Mutation_p.V368I	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	495	HEAT 13.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		ACTTTGGGAACAATAGTATTT	0.383													0	0	0	0.00245	0	13	168										T	111614171	C	T	111614171	3	4	26	1	0	0	0	0	1	0	0	0	12383	478	17	2	561	2	PPP2R1B	11	111614171	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	17382527	111614171	23392345	61	7224										
TECTA	7007	broad.mit.edu	37	chr11	121039497	121039497	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cagggtgaagtagtgttgacGactcgagatgtgctgtatgt	15	5	0	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr11:121039497G>C	uc010rzo.1	+	19	5862	c.5862G>C	c.(5860-5862)ACG>ACC	p.T1954T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1954	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGTGTTGACGACTCGAGATG	0.483													0	0	0	0.00333	0	25	63										C	121039497	G	C	121039497	2	2	26	1	0	0	0	0	0	0	0	1	15744	1045	37	1		1	TECTA	11	121039497	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	9425326	121039497	13967019	62	7225										
A2ML1	144568	broad.mit.edu	37	chr12	9006743	9006743	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggtcacattaactttactatTagtacaaagattctggacag	7	7	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr12:9006743T>A	uc001quz.3	+	21	2708	c.2610T>A	c.(2608-2610)ATT>ATA	p.I870I	A2ML1_uc001qva.1_Silent_p.I450I|A2ML1_uc010sgm.1_Silent_p.I370I	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	714						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ACTTTACTATTAGTACAAAGA	0.458													0	0	0	0.013537	0	13	39										A	9006743	T	A	9006743	2	1	26	1	0	0	0	0	0	0	0	1	5	1742	61	5		5	A2ML1	12	9006743	Silent	SNP	T	TCGA-C4-A0F7-01A-11D-A10S-08		9006743	124845152	63	7226										
MLL2	8085	broad.mit.edu	37	chr12	49425220	49425220	+	Frame_Shift_Del	DEL	G	G	-													0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	actgggctcccagggcacatGgctcttcccgaggttcctgc							TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr12:49425220delG	uc001rta.3	-	39	13268	c.13268delC	c.(13267-13269)CCAfs	p.P4423fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4423					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CAGGGCACATGGCTCTTCCCG	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								30	57	---	---								-	49425220	G	-	49425220	7	5	26	1	0	1	0	1	0	0	0	0	9621	1348	47	0	3409	0	MLL2	12	49425220	Frame_Shift_Del	DEL	G	TCGA-C4-A0F7-01A-11D-A10S-08	40418477	49425220	84426675	64	7227										
KRT74	121391	broad.mit.edu	37	chr12	52962081	52962081	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tccttggcctggtgcagggcGccctccagctcatccagctt	11	16	1	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr12:52962081G>A	uc001sap.1	-	7	1275	c.1227C>T	c.(1225-1227)GGC>GGT	p.G409G		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	409	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		GGTGCAGGGCGCCCTCCAGCT	0.652													0	0	0	0.00874	0	35	113										A	52962081	G	A	52962081	2	1	26	1	0	0	0	0	0	0	0	1	8487	1074	38	2		2	KRT74	12	52962081	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	3536861	52962081	80889814	65	7228										
HSP90B1	7184	broad.mit.edu	37	chr12	104326676	104326676	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggctaatatcactgactgatGaaaatgctctttctggaaat	8	7	3	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr12:104326676G>A	uc001tkb.1	+	4	472	c.367G>A	c.(367-369)GAA>AAA	p.E123K	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Missense_Mutation_p.E123K|LOC253724_uc010swf.1_5'Flank|LOC253724_uc009zuh.2_5'Flank	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	123					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	ACTGACTGATGAAAATGCTCT	0.343													0	0	0	0.01441	0	87	110										A	104326676	G	A	104326676	3	1	26	1	0	0	0	0	1	0	0	0	7403	1291	45	1	381	1	HSP90B1	12	104326676	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	51364595	104326676	29525219	66	7229										
RCBTB1	55213	broad.mit.edu	37	chr13	50129739	50129739	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gtaaacagtttgtaacttttCgaggagttggttgatttgct	11	4	0	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr13:50129739C>T	uc001vde.1	-	6	776	c.515G>A	c.(514-516)CGA>CAA	p.R172Q		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	172	RCC1 3.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		TGTAACTTTTCGAGGAGTTGG	0.443													0	0	0	0.004007	0	16	35										T	50129739	C	T	50129739	3	4	26	1	0	0	0	0	1	0	0	0	13171	884	31	1	1112	1	RCBTB1	13	50129739	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		50129739	65040139	67	7230										
SNW1	22938	broad.mit.edu	37	chr14	78184464	78184464	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctcttcttgccttcatgctcGtgttccttggggcggctgct	11	13	3	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr14:78184464G>A	uc001xuf.2	-	14	1605	c.1578C>T	c.(1576-1578)CAC>CAT	p.H526H	SNW1_uc010tvm.1_Silent_p.H451H|SNW1_uc010asu.2_Silent_p.H364H|SNW1_uc010tvn.1_Missense_Mutation_p.T553M	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein	526					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CTTCATGCTCGTGTTCCTTGG	0.468													0	0	0	0.01441	0	100	182										A	78184464	G	A	78184464	2	1	26	1	0	0	0	0	0	0	0	1	14879	1136	40	2		2	SNW1	14	78184464	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		78184464	29165076	68	7231										
ATP2A1	487	broad.mit.edu	37	chr16	28913653	28913653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tggaccgccccccccggagcCccaaggagcccctcatcagt	10	20	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr16:28913653C>T	uc002dro.1	+	17	2654	c.2470C>T	c.(2470-2472)CCC>TCC	p.P824S	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.P824S|ATP2A1_uc002drp.1_Missense_Mutation_p.P699S	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	824	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCCCGGAGCCCCAAGGAGCC	0.647													0	0	0	0.01441	0	51	631										T	28913653	C	T	28913653	3	4	26	1	0	0	0	0	1	0	0	0	1136	623	22	2	2536	2	ATP2A1	16	28913653	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		28913653	61441100	69	7232										
RPGRIP1L	23322	broad.mit.edu	37	chr16	53679568	53679568	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctgtcatgtgccaacgaaatCagaggcacattgacttttcc	8	11	2	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr16:53679568C>T	uc002ehp.2	-	17	2716	c.2652G>A	c.(2650-2652)CTG>CTA	p.L884L	RPGRIP1L_uc002eho.3_Silent_p.L884L|RPGRIP1L_uc010vgy.1_Silent_p.L884L|RPGRIP1L_uc010cbx.2_Silent_p.L884L|RPGRIP1L_uc010vgz.1_Silent_p.L884L	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	884					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				CCAACGAAATCAGAGGCACAT	0.333													0	0	0	0.012213	0	34	70										T	53679568	C	T	53679568	2	4	26	1	0	0	0	0	0	0	0	1	13550	813	29	1		1	RPGRIP1L	16	53679568	Silent	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	24765915	53679568	36675185	70	7233										
TP53	7157	broad.mit.edu	37	chr17	7577568	7577568	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cgcccatgcaggaactgttaCacatgtagttgtagtggatg	12	8	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	1.77791e-30	0.01441	2.02485e-30	60	8										A	7577568	C	A	7577568	3	1	26	1	0	0	0	0	1	0	0	0	16378	478	17	4	577	4	TP53	17	7577568	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		7577568	73617642	71	7234										
TP53I13	90313	broad.mit.edu	37	chr17	27899299	27899299	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tggtccccagcccactcgctCagccctgaggtttccctctg	9	18	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr17:27899299C>G	uc002hee.2	+	6	691	c.653C>G	c.(652-654)TCA>TGA	p.S218*		NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	218	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		CCCACTCGCTCAGCCCTGAGG	0.637													0	0	0	0.01441	0	55	13										G	27899299	C	G	27899299	4	3	26	1	0	0	0	0	0	1	0	0	16383	838	29	1	675	1	TP53I13	17	27899299	Nonsense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	20321731	27899299	53295911	72	7235										
CASKIN2	57513	broad.mit.edu	37	chr17	73498739	73498739	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctcagcatccccctctgtggGgccagggcggcttaggctgt	14	14	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr17:73498739G>A	uc002joc.2	-	18	2966	c.2416C>T	c.(2416-2418)CCC>TCC	p.P806S	CASKIN2_uc010wsc.1_Missense_Mutation_p.P724S	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	806	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCTCTGTGGGGCCAGGGCGG	0.701													0	0	0	0.009096	0	4	44										A	73498739	G	A	73498739	3	1	26	1	0	0	0	0	1	0	0	0	2667	1232	43	2	1204	2	CASKIN2	17	73498739	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	45599440	73498739	7696471	73	7236										
CCDC57	284001	broad.mit.edu	37	chr17	80059594	80059594	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tagttacggatcttggggggCctctggcagcctttagcttt	13	9	2	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr17:80059594C>G	uc002kdx.1	-	17	2749	c.2712G>C	c.(2710-2712)AGG>AGC	p.R904S		NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	905										ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			TCTTGGGGGGCCTCTGGCAGC	0.612													0	0	0	0.01441	0	210	45										G	80059594	C	G	80059594	3	3	26	1	0	0	0	0	1	0	0	0	2827	738	26	4	39	4	CCDC57	17	80059594	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	6560855	80059594	1135616	74	7237										
SETBP1	26040	broad.mit.edu	37	chr18	42530725	42530725	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tgagtaaaatgatagagaatGagtccccctcagttggcctt	10	8	1	4			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr18:42530725G>A	uc010dni.2	+	4	1716	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	474						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GATAGAGAATGAGTCCCCCTC	0.483									Schinzel-Giedion_syndrome				0	0	0	0.01441	0	66	27										A	42530725	G	A	42530725	3	1	26	1	0	0	0	0	1	0	0	0	14129	1291	45	1	1623	1	SETBP1	18	42530725	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		42530725	35546523	75	7238										
HDGFRP2	84717	broad.mit.edu	37	chr19	4499523	4499523	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gcgaacaaggacgtaatggaGaaggcagcagaagtctatac	13	7	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:4499523G>A	uc002mao.2	+	14	1704	c.1611G>A	c.(1609-1611)GAG>GAA	p.E537E	HDGFRP2_uc002map.2_Silent_p.E537E|HDGFRP2_uc010dtz.1_RNA|HDGFRP2_uc010dua.2_Silent_p.E2E|HDGFRP2_uc002maq.1_Silent_p.E2E	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	537	Potential.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						ACGTAATGGAGAAGGCAGCAG	0.463													0	0	0	0.004482	0	9	47										A	4499523	G	A	4499523	2	1	26	1	0	0	0	0	0	0	0	1	7020	933	33	1		1	HDGFRP2	19	4499523	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		4499523	54629460	76	7239										
PRR22	163154	broad.mit.edu	37	chr19	5783026	5783026	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ccaggtcctccctgggccccGggggagtggcgctggctggg	19	14	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:5783026G>A	uc002mdb.1	-	1	1585	c.1226C>T	c.(1225-1227)CCG>CTG	p.P409L	PRR22_uc010xiv.1_Missense_Mutation_p.P411L	NM_153359	NP_699190	Q8IZ63	PRR22_HUMAN	proline rich 22 isoform 2	409											0						CCTGGGCCCCGGGGGAGTGGC	0.667													0	0	0	0.004482	0	6	11										A	5783026	G	A	5783026	3	1	26	1	0	0	0	0	1	0	0	0	12593	1116	39	2	40	2	PRR22	19	5783026	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	1283503	5783026	53345957	77	7240										
C19orf39	126074	broad.mit.edu	37	chr19	11486191	11486191	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ttctgtttctccttctagaaGatccgcttccagtacccacc	5	15	3	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:11486191G>A	uc002mrg.1	+	2	226	c.189G>A	c.(187-189)AAG>AAA	p.K63K		NM_175871	NP_787067	Q6NVH7	CS039_HUMAN	hypothetical protein LOC126074	63											0						CCTTCTAGAAGATCCGCTTCC	0.582													0	0	0	0.01441	0	99	308										A	11486191	G	A	11486191	2	1	26	1	0	0	0	0	0	0	0	1	1922	933	33	1		1	C19orf39	19	11486191	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	5703165	11486191	47642792	78	7241										
ANO8	57719	broad.mit.edu	37	chr19	17440975	17440975	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctagcttcttgtagccctcgGcactcacactgacaagcagg	9	14	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:17440975G>T	uc002ngf.2	-	10	1391	c.1232C>A	c.(1231-1233)GCC>GAC	p.A411D	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	411	Helical; (Potential).|Leu-rich.					chloride channel complex	chloride channel activity			ovary(3)	3						GTAGCCCTCGGCACTCACACT	0.627													1	0	4.7796e-09	0.004656	5.1121e-09	26	78										T	17440975	G	T	17440975	3	4	26	1	0	0	0	0	1	0	0	0	703	1203	42	4	2502	4	ANO8	19	17440975	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	5954784	17440975	41688008	79	7242										
ZNF461	92283	broad.mit.edu	37	chr19	37147421	37147421	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cttgctccaatgaggagattAcggctggcttagaaacagaa	11	8	0	4			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:37147421A>G	uc002oem.2	-	4	389	c.161T>C	c.(160-162)GTA>GCA	p.V54A	ZNF461_uc002oen.2_Missense_Mutation_p.V23A|ZNF461_uc010xtj.1_Missense_Mutation_p.V54A	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TGAGGAGATTACGGCTGGCTT	0.433													0	0	0	0.004672	0	3	67										G	37147421	A	G	37147421	3	3	26	1	0	0	0	0	1	0	0	0	17922	391	14	5	1542	5	ZNF461	19	37147421	Missense_Mutation	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08	19706446	37147421	21981562	80	7243										
ZNF567	163081	broad.mit.edu	37	chr19	37210842	37210842	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggaagtcctttcaccagaagGcaaatcttactgtacatcag	8	10	3	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:37210842G>T	uc010xtl.1	+	6	1438	c.1216G>T	c.(1216-1218)GCA>TCA	p.A406S	ZNF567_uc002oeo.1_Missense_Mutation_p.A406S|ZNF567_uc010xtk.1_Missense_Mutation_p.A406S|ZNF567_uc002oep.3_Missense_Mutation_p.A375S|ZNF567_uc002oeq.1_Missense_Mutation_p.A375S	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	406	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCACCAGAAGGCAAATCTTAC	0.433													1	0	2.48551e-13	0.00499	2.68173e-13	17	56										T	37210842	G	T	37210842	3	4	26	1	0	0	0	0	1	0	0	0	17995	1203	42	4	1133	4	ZNF567	19	37210842	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	63421	37210842	21918141	81	7244										
SULT2B1	6820	broad.mit.edu	37	chr19	49055556	49055556	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cccgggcttgtgggacacctAtgaagatgacatctcggaaa	12	10	1	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:49055556A>T	uc002pjl.2	+	1	128	c.47A>T	c.(46-48)TAT>TTT	p.Y16F		NM_177973	NP_814444	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	16				Missing: Increases the cholesterol sulfotransferase activity.|Missing: Loss of the cholesterol sulfotransferase activity.	3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		TGGGACACCTATGAAGATGAC	0.672													0	0	0	0.010504	0	18	34										T	49055556	A	T	49055556	3	4	26	1	0	0	0	0	1	0	0	0	15379	449	16	5	49	5	SULT2B1	19	49055556	Missense_Mutation	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08	11844714	49055556	10073427	82	7245										
KLK5	25818	broad.mit.edu	37	chr19	51453127	51453127	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	tcacttcttcctgcagtgggCggccgtgagcagccactgtg	13	13	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:51453127C>T	uc002pue.2	-	4	537	c.319G>A	c.(319-321)GCC>ACC	p.A107T	KLK5_uc002puf.2_Missense_Mutation_p.A107T|KLK5_uc002pug.2_Missense_Mutation_p.A107T	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	107	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		CTGCAGTGGGCGGCCGTGAGC	0.512													0	0	0	0.010771	0	40	11										T	51453127	C	T	51453127	3	4	26	1	0	0	0	0	1	0	0	0	8407	768	27	2	578	2	KLK5	19	51453127	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	2397571	51453127	7675856	83	7246										
SAPS1	22870	broad.mit.edu	37	chr19	55758320	55758320	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ccattgcttgcaggtggggtGgctgcagcaggaagtccagc	16	10	0	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr19:55758320G>A	uc002qjw.3	-	2	394	c.152C>T	c.(151-153)CCA>CTA	p.P51L	SAPS1_uc002qjv.2_Missense_Mutation_p.P113L	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	51	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CAGGTGGGGTGGCTGCAGCAG	0.657													0	0	0	0.010504	0	19	30										A	55758320	G	A	55758320	3	1	26	1	0	0	0	0	1	0	0	0	13836	1348	47	2	2585	2	SAPS1	19	55758320	Missense_Mutation	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	4305193	55758320	3370663	84	7247										
IFNGR2	3460	broad.mit.edu	37	chr21	34805103	34805103	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ctggcaggagcctgtttcttCctggtcctgaaatatagagg	12	9	1	2			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr21:34805103C>A	uc002yrp.3	+	6	1452	c.804C>A	c.(802-804)TTC>TTA	p.F268L	IFNGR2_uc002yrq.3_Missense_Mutation_p.F287L|IFNGR2_uc010gma.2_Missense_Mutation_p.F189L|IFNGR2_uc002yrr.3_Missense_Mutation_p.F189L|TMEM50B_uc002yrs.1_RNA	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	268	Helical; (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	CCTGTTTCTTCCTGGTCCTGA	0.468													1	0	1.62957e-23	0.00874	1.82216e-23	45	85										A	34805103	C	A	34805103	3	1	26	1	0	0	0	0	1	0	0	0	7550	854	30	3	826	3	IFNGR2	21	34805103	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08		34805103	13324792	85	7248										
SLC19A1	6573	broad.mit.edu	37	chr21	46951334	46951334	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	gaggcagcatctgccgcgccGttgtagacccgcgcactgtt	13	14	1	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr21:46951334G>A	uc002zhl.1	-	3	1037	c.918C>T	c.(916-918)AAC>AAT	p.N306N	SLC19A1_uc010gpy.1_Silent_p.N306N|SLC19A1_uc011aft.1_Silent_p.N266N|SLC19A1_uc002zhm.1_Silent_p.N306N|SLC19A1_uc010gpz.1_Silent_p.N185N	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	306	Extracellular (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		CTGCCGCGCCGTTGTAGACCC	0.662													0	0	0	0.004878	0	34	103										A	46951334	G	A	46951334	2	1	26	1	0	0	0	0	0	0	0	1	14428	1136	40	2		2	SLC19A1	21	46951334	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	12146231	46951334	1178561	86	7249										
C22orf24	25775	broad.mit.edu	37	chr22	32334024	32334024	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	aaagacttgtcttttgatgcAgccctgttgtatcctcttga	8	9	2	3			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr22:32334024A>G	uc003aly.2	-	2	196	c.29T>C	c.(28-30)CTG>CCG	p.L10P	C22orf24_uc003alx.2_RNA	NM_015372	NP_056187	Q9Y442	CV024_HUMAN	hypothetical protein LOC25775	10						integral to membrane				central_nervous_system(1)	1						CTTTTGATGCAGCCCTGTTGT	0.378													0	0	0	0.01441	0	124	348										G	32334024	A	G	32334024	3	3	26	1	0	0	0	0	1	0	0	0	2138	188	7	5	461	5	C22orf24	22	32334024	Missense_Mutation	SNP	A	TCGA-C4-A0F7-01A-11D-A10S-08		32334024	18970542	87	7250										
TST	7263	broad.mit.edu	37	chr22	37414345	37414345	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	ggttctgggcgtgagggctcGgatgtcaccgggtggccctc	18	11	2	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chr22:37414345G>A	uc003aqg.2	-	1	1129	c.429C>T	c.(427-429)TCC>TCT	p.S143S	TST_uc003aqh.2_Silent_p.S143S|MPST_uc003aqi.1_5'Flank|MPST_uc003aqj.2_5'Flank|MPST_uc003aqm.2_5'Flank|MPST_uc011amu.1_5'Flank|MPST_uc003aql.2_5'Flank	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	143	Rhodanese 1.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						GTGAGGGCTCGGATGTCACCG	0.607													0	0	0	0.00278	0	25	71										A	37414345	G	A	37414345	2	1	26	1	0	0	0	0	0	0	0	1	16670	1103	39	2		2	TST	22	37414345	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08	5080321	37414345	13890221	88	7251										
ZNF645	158506	broad.mit.edu	37	chrX	22291957	22291957	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cctcagaaacagcattatgcGccacctccatctccatcatc	4	17	3	1			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chrX:22291957G>A	uc004dai.1	+	1	898	c.849G>A	c.(847-849)GCG>GCA	p.A283A		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	283	Pro-rich.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						AGCATTATGCGCCACCTCCAT	0.473													0	0	0	0.01441	0	69	20										A	22291957	G	A	22291957	2	1	26	1	0	0	0	0	0	0	0	1	18058	1074	38	2		2	ZNF645	23	22291957	Silent	SNP	G	TCGA-C4-A0F7-01A-11D-A10S-08		22291957	132978603	89	7252										
FLNA	2316	broad.mit.edu	37	chrX	153592464	153592464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.144444444444444	13	0.0324397931874628	1.78084767828728	1.69865470852018	1.79665401862711	0.0025092716799495	0.011248459254946	6	cttcaccggcttcctgggcaCgtaggagcagctgtaagtgc	13	12	1	0			TCGA-C4-A0F7-01A-11D-A10S-08	TCGA-C4-A0F7-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f389176f-d8f3-45c2-aae4-7378a3d6fc7f	df7ba0ba-91dd-453c-b60b-699994ec4b3b	g.chrX:153592464C>T	uc004fkk.2	-	15	2455	c.2206G>A	c.(2206-2208)GTG>ATG	p.V736M	FLNA_uc010nuu.1_Missense_Mutation_p.V736M	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	736	Filamin 5.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTCCTGGGCACGTAGGAGCAG	0.612													0	0	0	0.01441	0	73	18										T	153592464	C	T	153592464	3	4	26	1	0	0	0	0	1	0	0	0	5933	536	19	2	5873	2	FLNA	23	153592464	Missense_Mutation	SNP	C	TCGA-C4-A0F7-01A-11D-A10S-08	131300507	153592464	1678096	90	7253										
NOC2L	26155	broad.mit.edu	37	chr1	880485	880485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcctcctcgtcctcttcatCgtcttccaccccatgccgag	5	20	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:880485C>T	uc001abz.3	-	18	2154	c.2095G>A	c.(2095-2097)GAT>AAT	p.D699N	NOC2L_uc001aby.3_Missense_Mutation_p.D496N|NOC2L_uc009vjq.2_Missense_Mutation_p.D699N	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	699	Asp/Glu-rich (acidic).					nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		tcctcttcatcgtcttccacc	0.468													0	0	0	0.008291	0	9	13										T	880485	C	T	880485	3	4	27	1	0	0	0	0	1	0	0	0	10513	884	31	1	162	1	NOC2L	1	880485	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		880485	248370136	1	7254										
VWA1	64856	broad.mit.edu	37	chr1	1374667	1374667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcgacccggacacggactacGacgtggcgctagtgcctgag	14	13	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:1374667G>A	uc001afs.2	+	3	1058	c.838G>A	c.(838-840)GAC>AAC	p.D280N	VWA1_uc001afr.2_Missense_Mutation_p.D68N	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	280	Fibronectin type-III 1.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CACGGACTACGACGTGGCGCT	0.741													0	0	0	0.009096	0	4	8										A	1374667	G	A	1374667	3	1	27	1	0	0	0	0	1	0	0	0	17235	1058	37	1	848	1	VWA1	1	1374667	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	494182	1374667	247875954	2	7255										
TAS1R1	80835	broad.mit.edu	37	chr1	6634783	6634783	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aatgacaagtaccaggtggaGaccatggtgctgctgctgca	13	9	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:6634783G>A	uc001ant.2	+	3	591	c.591G>A	c.(589-591)GAG>GAA	p.E197E	TAS1R1_uc001anu.2_Intron|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_Silent_p.E197E	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	197	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		ACCAGGTGGAGACCATGGTGC	0.587													0	0	0	0.004482	0	9	40										A	6634783	G	A	6634783	2	1	27	1	0	0	0	0	0	0	0	1	15559	933	33	1		1	TAS1R1	1	6634783	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5260116	6634783	242615838	3	7256										
TNFRSF8	943	broad.mit.edu	37	chr1	12164562	12164562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cttcttccattctgtctgtcCggcagggatgattgtcaagt	10	10	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:12164562C>T	uc001atq.2	+	4	617	c.395C>T	c.(394-396)CCG>CTG	p.P132L	TNFRSF8_uc010obc.1_Missense_Mutation_p.P21L	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	132	TNFR-Cys 3.|Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TCTGTCTGTCCGGCAGGGATG	0.577													0	0	0	0.008291	0	9	21										T	12164562	C	T	12164562	3	4	27	1	0	0	0	0	1	0	0	0	16296	652	23	2	409	2	TNFRSF8	1	12164562	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5529779	12164562	237086059	4	7257										
FBLIM1	54751	broad.mit.edu	37	chr1	16111108	16111108	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	taccccctgaacaaccatctCttctgcaagccatgccatgt	5	16	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:16111108C>G	uc001axd.1	+	10	1517	c.1074C>G	c.(1072-1074)CTC>CTG	p.L358L	FBLIM1_uc001axe.1_Silent_p.L358L|FBLIM1_uc001axf.2_RNA|FBLIM1_uc001axh.1_Silent_p.L261L|FBLIM1_uc001axi.1_Silent_p.L261L	NM_017556	NP_060026	Q8WUP2	FBLI1_HUMAN	filamin-binding LIM protein-1 isoform a	358	PLEKHC1-binding.|LIM zinc-binding 3.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			skin(1)	1		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		ACAACCATCTCTTCTGCAAGC	0.637													0	0	0	0.001984	0	6	75										G	16111108	C	G	16111108	2	3	27	1	0	0	0	0	0	0	0	1	5697	900	32	1		1	FBLIM1	1	16111108	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3946546	16111108	233139513	5	7258										
FBXO42	54455	broad.mit.edu	37	chr1	16641903	16641903	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtcatcttcactgtccgagGagctggccatgacattccac	9	13	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:16641903G>A	uc001ayg.2	-	2	227	c.11C>T	c.(10-12)TCC>TTC	p.S4F	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.S4F	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	4										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ACTGTCCGAGGAGCTGGCCAT	0.458													0	0	0	0.010729	0	10	65										A	16641903	G	A	16641903	3	1	27	1	0	0	0	0	1	0	0	0	5751	1174	41	1	2178	1	FBXO42	1	16641903	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	530795	16641903	232608718	6	7259										
SPATA21	374955	broad.mit.edu	37	chr1	16727277	16727277	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttcgttctggaacttctgagCtctcttcttgctgggggttg	12	9	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:16727277C>T	uc001ayn.2	-	11	1595	c.1112G>A	c.(1111-1113)AGC>AAC	p.S371N	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Missense_Mutation_p.S348N	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	371							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		AACTTCTGAGCTCTCTTCTTG	0.592													0	0	0	0.004007	0	17	209										T	16727277	C	T	16727277	3	4	27	1	0	0	0	0	1	0	0	0	15006	797	28	2	309	2	SPATA21	1	16727277	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	85374	16727277	232523344	7	7260										
HP1BP3	50809	broad.mit.edu	37	chr1	21103139	21103139	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttcttccttctcttcattctCaggttccccctttggctgct	5	15	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:21103139C>T	uc001bdw.1	-	4	441	c.301G>A	c.(301-303)GAG>AAG	p.E101K	HP1BP3_uc001bdv.1_Missense_Mutation_p.E63K|HP1BP3_uc010odh.1_Missense_Mutation_p.E63K|HP1BP3_uc001bdy.1_Missense_Mutation_p.E101K|HP1BP3_uc001bdz.2_RNA|HP1BP3_uc001bea.2_Missense_Mutation_p.E100K|HP1BP3_uc001beb.2_Missense_Mutation_p.E101K	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	101					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TCTTCATTCTCAGGTTCCCCC	0.403													0	0	0	0.01441	0	65	147										T	21103139	C	T	21103139	3	4	27	1	0	0	0	0	1	0	0	0	7328	835	29	1	1400	1	HP1BP3	1	21103139	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4375862	21103139	228147482	8	7261										
CELA3A	10136	broad.mit.edu	37	chr1	22336318	22336318	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggaagcccacggtgttcactCgagtctccgccttcatcgac	10	15	3	0	rs148724731		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:22336318C>G	uc001bfl.2	+	7	782	c.763C>G	c.(763-765)CGA>GGA	p.R255G		NM_005747	NP_005738	P09093	CEL3A_HUMAN	elastase 3A, pancreatic preproprotein	255	Peptidase S1.				cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1						GGTGTTCACTCGAGTCTCCGC	0.592													0	0	0	0.013537	0	11	55										G	22336318	C	G	22336318	3	3	27	1	0	0	0	0	1	0	0	0	3213	876	31	1	789	1	CELA3A	1	22336318	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1233179	22336318	226914303	9	7262										
ARID1A	8289	broad.mit.edu	37	chr1	27102121	27102121	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcaagtctggtctcctggcaGagagcacatgggcattagat	12	9	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:27102121G>C	uc001bmv.1	+	19	5420	c.5047G>C	c.(5047-5049)GAG>CAG	p.E1683Q	ARID1A_uc001bmt.1_Missense_Mutation_p.E1682Q|ARID1A_uc001bmu.1_Missense_Mutation_p.E1466Q|ARID1A_uc001bmx.1_Missense_Mutation_p.E529Q|ARID1A_uc009vsm.1_Missense_Mutation_p.E11Q|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1683					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCTCCTGGCAGAGAGCACATG	0.522			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.001984	0	7	27										C	27102121	G	C	27102121	3	2	27	1	0	0	0	0	1	0	0	0	913	943	33	1	5121	1	ARID1A	1	27102121	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4765803	27102121	222148500	10	7263										
SPOCD1	90853	broad.mit.edu	37	chr1	32280503	32280503	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccctgcaggccagagctctCtctgggaggccagcagacct	12	15	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:32280503C>G	uc001bts.1	-	2	490	c.432G>C	c.(430-432)GAG>GAC	p.E144D	SPOCD1_uc001btu.2_Missense_Mutation_p.E144D|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	144					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCAGAGCTCTCTCTGGGAGGC	0.592													0	0	0	0.01441	0	36	92										G	32280503	C	G	32280503	3	3	27	1	0	0	0	0	1	0	0	0	15077	912	32	1	3278	1	SPOCD1	1	32280503	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5178382	32280503	216970118	11	7264										
LCK	3932	broad.mit.edu	37	chr1	32742252	32742252	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tggcggtgaagagcctgaagCagggcagcatgtccccggac	16	11	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:32742252C>A	uc001bux.2	+	9	967	c.829C>A	c.(829-831)CAG>AAG	p.Q277K	LCK_uc001buy.2_Missense_Mutation_p.Q277K|LCK_uc001buz.2_Missense_Mutation_p.Q277K|LCK_uc010ohc.1_Missense_Mutation_p.Q321K|LCK_uc001bva.2_Missense_Mutation_p.Q284K	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	277	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GAGCCTGAAGCAGGGCAGCAT	0.637			T	TRB@	T-ALL								1	0	2.23348e-06	0.004007	2.37504e-06	16	58										A	32742252	C	A	32742252	3	1	27	1	0	0	0	0	1	0	0	0	8676	711	25	4	859	4	LCK	1	32742252	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	461749	32742252	216508369	12	7265										
RNF220	55182	broad.mit.edu	37	chr1	45115332	45115332	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	accatgccttcctttttacaGaatcaccgaagattcagctg	6	12	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:45115332G>A	uc001clv.1	+	13	1806	c.1446_splice	c.e13-1	p.K482_splice	RNF220_uc001clw.1_Splice_Site_p.K482_splice|RNF220_uc010oky.1_Splice_Site_p.K269_splice|RNF220_uc010okz.1_Splice_Site_p.K224_splice|RNF220_uc001clx.1_Splice_Site_p.K198_splice|RNF220_uc001cly.1_Splice_Site_p.K162_splice|RNF220_uc001clz.1_Splice_Site_p.K161_splice|RNF220_uc001cma.1_Splice_Site_p.K161_splice|TMEM53_uc001cmb.1_Intron	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220						protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CCTTTTTACAGAATCACCGAA	0.338													0	0	0	0.00308	0	8	124										A	45115332	G	A	45115332	5	1	27	1	0	0	0	0	0	0	1	0	13483	956	33	1	1491	1	RNF220	1	45115332	Splice_Site	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	12373080	45115332	204135289	13	7266										
TMEM53	79639	broad.mit.edu	37	chr1	45120468	45120468	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcgtcctgtagcctgtcataGaagtgggtgtggaagagggc	17	7	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:45120468G>C	uc001cmc.2	-	3	633	c.597C>G	c.(595-597)TTC>TTG	p.F199L	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Missense_Mutation_p.F126L|TMEM53_uc009vxh.1_Missense_Mutation_p.F82L|TMEM53_uc010ola.1_Missense_Mutation_p.F82L	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	199						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					GCCTGTCATAGAAGTGGGTGT	0.617													0	0	0	0.008291	0	10	41										C	45120468	G	C	45120468	3	2	27	1	0	0	0	0	1	0	0	0	16176	933	33	1	240	1	TMEM53	1	45120468	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5136	45120468	204130153	14	7267										
ZFYVE9	9372	broad.mit.edu	37	chr1	52704276	52704276	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gacagagcatttctctgaatCtcaggacatgactaattgga	9	8	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52704276C>T	uc001cto.2	+	4	1359	c.1187C>T	c.(1186-1188)TCT>TTT	p.S396F	ZFYVE9_uc001ctn.2_Missense_Mutation_p.S396F|ZFYVE9_uc001ctp.2_Missense_Mutation_p.S396F	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	396					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TTCTCTGAATCTCAGGACATG	0.368													0	0	0	0.004656	0	25	126										T	52704276	C	T	52704276	3	4	27	1	0	0	0	0	1	0	0	0	17668	913	32	1	1193	1	ZFYVE9	1	52704276	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	7583808	52704276	196546345	15	7268			1	23		5	5	833	C		4.189232e-10
ZFYVE9	9372	broad.mit.edu	37	chr1	52704805	52704805	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtagcaagcctgccatctatCagtgttccttttggtggtgc	11	10	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52704805C>T	uc001cto.2	+	4	1888	c.1716C>T	c.(1714-1716)ATC>ATT	p.I572I	ZFYVE9_uc001ctn.2_Silent_p.I572I|ZFYVE9_uc001ctp.2_Silent_p.I572I	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	572					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TGCCATCTATCAGTGTTCCTT	0.393													0	0	0	0.003163	0	15	87										T	52704805	C	T	52704805	2	4	27	1	0	0	0	0	0	0	0	1	17668	816	29	1		1	ZFYVE9	1	52704805	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	529	52704805	196545816	16	7269			1	23		5	5	833	C		4.189232e-10
ZFYVE9	9372	broad.mit.edu	37	chr1	52704876	52704876	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcaaattccaaagccattatCagaccatttacaaaatgact	3	10	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52704876C>T	uc001cto.2	+	4	1959	c.1787C>T	c.(1786-1788)TCA>TTA	p.S596L	ZFYVE9_uc001ctn.2_Missense_Mutation_p.S596L|ZFYVE9_uc001ctp.2_Missense_Mutation_p.S596L	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	596					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						AAGCCATTATCAGACCATTTA	0.378													0	0	0	0.010729	0	12	77										T	52704876	C	T	52704876	3	4	27	1	0	0	0	0	1	0	0	0	17668	838	29	1	1793	1	ZFYVE9	1	52704876	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	71	52704876	196545745	17	7270			1	23		5	5	833	C		4.189232e-10
ZFYVE9	9372	broad.mit.edu	37	chr1	52705008	52705008	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccatctttgggaaacatctCtaatgtcgatacaaatgggg	9	8	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52705008C>G	uc001cto.2	+	4	2091	c.1919C>G	c.(1918-1920)TCT>TGT	p.S640C	ZFYVE9_uc001ctn.2_Missense_Mutation_p.S640C|ZFYVE9_uc001ctp.2_Missense_Mutation_p.S640C	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	640					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						GGAAACATCTCTAATGTCGAT	0.378													0	0	0	0.003954	0	25	113										G	52705008	C	G	52705008	3	3	27	1	0	0	0	0	1	0	0	0	17668	913	32	1	1925	1	ZFYVE9	1	52705008	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	132	52705008	196545613	18	7271			1	23		5	5	833	C		4.189232e-10
ZFYVE9	9372	broad.mit.edu	37	chr1	52705108	52705108	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatagcccagataatgatctCagagctggtcagtttggaat	11	7	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52705108C>T	uc001cto.2	+	4	2191	c.2019C>T	c.(2017-2019)CTC>CTT	p.L673L	ZFYVE9_uc001ctn.2_Silent_p.L673L|ZFYVE9_uc001ctp.2_Silent_p.L673L	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	673					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						ATAATGATCTCAGAGCTGGTC	0.468													0	0	0	0.00278	0	21	126										T	52705108	C	T	52705108	2	4	27	1	0	0	0	0	0	0	0	1	17668	813	29	1		1	ZFYVE9	1	52705108	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	100	52705108	196545513	19	7272			1	23		5	5	833	C		4.189232e-10
ZCCHC11	23318	broad.mit.edu	37	chr1	52940613	52940613	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgtagctttgcagttgcaaGaggtagcagatgtgtcggtg	15	6	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52940613G>T	uc001ctx.2	-	13	2852	c.2618C>A	c.(2617-2619)TCT>TAT	p.S873Y	ZCCHC11_uc001cty.2_Missense_Mutation_p.S873Y|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S873Y|ZCCHC11_uc009vze.1_Missense_Mutation_p.S873Y|ZCCHC11_uc009vzf.1_Missense_Mutation_p.S632Y|ZCCHC11_uc001cub.2_Missense_Mutation_p.S873Y	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	873					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						GCAGTTGCAAGAGGTAGCAGA	0.413													1	0	1.58986e-06	0.008291	1.69461e-06	10	72										T	52940613	G	T	52940613	3	4	27	1	0	0	0	0	1	0	0	0	17577	942	33	3	2391	3	ZCCHC11	1	52940613	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	235505	52940613	196310008	20	7273										
ZCCHC11	23318	broad.mit.edu	37	chr1	52940833	52940833	+	Missense_Mutation	SNP	G	G	T													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	actgcttttgctggtagaaaGagatgaagagtcctgtccgt							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52940833G>T	uc001ctx.2	-	13	2632	c.2398C>A	c.(2398-2400)CTT>ATT	p.L800I	ZCCHC11_uc001cty.2_Missense_Mutation_p.L800I|ZCCHC11_uc001ctz.2_Missense_Mutation_p.L800I|ZCCHC11_uc009vze.1_Missense_Mutation_p.L800I|ZCCHC11_uc009vzf.1_Missense_Mutation_p.L559I|ZCCHC11_uc001cub.2_Missense_Mutation_p.L800I	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	800					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						CTGGTAGAAAGAGATGAAGAG	0.363													1	0	0.000308642	0.003163	0.000320676	13	218										T	52940833	G	T	52940833	3	4	27	1	0	0	0	0	1	0	0	0	17577	942	33	3	2611	3	ZCCHC11	1	52940833	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	220	52940833	196309788	21	7274	33	2								
ZCCHC11	23318	broad.mit.edu	37	chr1	52940841	52940841	+	Missense_Mutation	SNP	G	G	C													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgctggtagaaagagatgaaGagtcctgtccgtggtcagca							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:52940841G>C	uc001ctx.2	-	13	2624	c.2390C>G	c.(2389-2391)TCT>TGT	p.S797C	ZCCHC11_uc001cty.2_Missense_Mutation_p.S797C|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S797C|ZCCHC11_uc009vze.1_Missense_Mutation_p.S797C|ZCCHC11_uc009vzf.1_Missense_Mutation_p.S556C|ZCCHC11_uc001cub.2_Missense_Mutation_p.S797C	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	797					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AAGAGATGAAGAGTCCTGTCC	0.358													0	0	0	0.00245	0	13	225										C	52940841	G	C	52940841	3	2	27	1	0	0	0	0	1	0	0	0	17577	942	33	1	2619	1	ZCCHC11	1	52940841	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8	52940841	196309780	22	7275	33	2								
EXTL2	2135	broad.mit.edu	37	chr1	101339508	101339508	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgttttacttttatatttttCttttgtagttggcatatgga	7	3	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:101339508C>G	uc001dtk.1	-	5	1320	c.983G>C	c.(982-984)AGA>ACA	p.R328T	EXTL2_uc001dtl.1_Missense_Mutation_p.R328T|EXTL2_uc010ouk.1_Missense_Mutation_p.R315T|EXTL2_uc001dtm.1_Missense_Mutation_p.R327T	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	328	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		TTATATTTTTCTTTTGTAGTT	0.299													0	0	0	0.010729	0	11	97										G	101339508	C	G	101339508	3	3	27	1	0	0	0	0	1	0	0	0	5326	913	32	1	13	1	EXTL2	1	101339508	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	48398667	101339508	147911113	23	7276										
MTMR11	10903	broad.mit.edu	37	chr1	149906110	149906110	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctacgtcgaacctctcgttGaccgtgctgaccctccagcc	9	17	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:149906110G>A	uc001etl.3	-	7	908	c.657C>T	c.(655-657)GTC>GTT	p.V219V	MTMR11_uc001etm.1_Silent_p.V147V|MTMR11_uc010pbm.1_Silent_p.V191V|MTMR11_uc010pbn.1_Silent_p.V61V	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	219	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACCTCTCGTTGACCGTGCTGA	0.572													0	0	0	0.010729	0	12	106										A	149906110	G	A	149906110	2	1	27	1	0	0	0	0	0	0	0	1	9940	1277	45	1		1	MTMR11	1	149906110	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	48566602	149906110	99344511	24	7277										
PRPF3	9129	broad.mit.edu	37	chr1	150325402	150325402	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atttcaaaaagcatggggctGaacactactgggaccttgcg	11	9	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:150325402G>A	uc001eum.3	+	16	2161	c.1999G>A	c.(1999-2001)GAA>AAA	p.E667K	PRPF3_uc010pca.1_Missense_Mutation_p.E626K|PRPF3_uc010pcb.1_Missense_Mutation_p.E618K	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	667					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		GCATGGGGCTGAACACTACTG	0.488													0	0	0	0.008291	0	11	135										A	150325402	G	A	150325402	3	1	27	1	0	0	0	0	1	0	0	0	12565	1291	45	1	2057	1	PRPF3	1	150325402	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	419292	150325402	98925219	25	7278										
TCHH	7062	broad.mit.edu	37	chr1	152085383	152085383	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	taacaggctctcctttccgtCacaccgggctcgcttctcct	7	17	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:152085383C>T	uc001ezp.2	-	2	310	c.310G>A	c.(310-312)GAC>AAC	p.D104N	TCHH_uc009wne.1_Missense_Mutation_p.D104N	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	104					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTTCCGTCACACCGGGCT	0.522													0	0	0	0.010504	0	20	170										T	152085383	C	T	152085383	3	4	27	1	0	0	0	0	1	0	0	0	15697	826	29	1	5525	1	TCHH	1	152085383	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1759981	152085383	97165238	26	7279										
FLG	2312	broad.mit.edu	37	chr1	152275916	152275916	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccgtctcctgactgttcctCattacgtgtttctctgcttg	8	13	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:152275916C>G	uc001ezu.1	-	3	11482	c.11446G>C	c.(11446-11448)GAG>CAG	p.E3816Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3816	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTGTTCCTCATTACGTGTT	0.577									Ichthyosis				0	0	0	0.00308	0	8	612										G	152275916	C	G	152275916	3	3	27	1	0	0	0	0	1	0	0	0	5922	835	29	1	743	1	FLG	1	152275916	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	190533	152275916	96974705	27	7280										
FLG	2312	broad.mit.edu	37	chr1	152285757	152285757	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gagtgtccagacctatttacCgattgctcgtggtgggatcc	12	10	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:152285757C>T	uc001ezu.1	-	3	1641	c.1605G>A	c.(1603-1605)TCG>TCA	p.S535S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	535	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTATTTACCGATTGCTCGT	0.582									Ichthyosis				0	0	0	0.01441	0	89	479										T	152285757	C	T	152285757	2	4	27	1	0	0	0	0	0	0	0	1	5922	639	23	2		2	FLG	1	152285757	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9841	152285757	96964864	28	7281										
OR6K6	128371	broad.mit.edu	37	chr1	158724630	158724630	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agcaatattcagtgggtaatCaacattccaattataggagt	8	6	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:158724630C>G	uc001fsw.1	+	1	25	c.25C>G	c.(25-27)CAA>GAA	p.Q9E		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					AGTGGGTAATCAACATTCCAA	0.393													0	0	0	0.010504	0	21	128										G	158724630	C	G	158724630	3	3	27	1	0	0	0	0	1	0	0	0	11204	827	29	1	27	1	OR6K6	1	158724630	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6438873	158724630	90525991	29	7282										
MNDA	4332	broad.mit.edu	37	chr1	158813830	158813830	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	taagcccccaggtccctcagGagccagcacatctgcagctg	10	16	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:158813830G>A	uc001fsz.1	+	4	688	c.488G>A	c.(487-489)GGA>GAA	p.G163E		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	163					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					GGTCCCTCAGGAGCCAGCACA	0.483													0	0	0	0.010729	0	10	143										A	158813830	G	A	158813830	3	1	27	1	0	0	0	0	1	0	0	0	9676	1174	41	1	498	1	MNDA	1	158813830	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	89200	158813830	90436791	30	7283										
KIFAP3	22920	broad.mit.edu	37	chr1	169993598	169993598	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ataaaaatgctgagtttcttCaagaatgacacaactaaaat	5	6	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:169993598C>G	uc001ggv.2	-	9	1252	c.981G>C	c.(979-981)TTG>TTC	p.L327F	KIFAP3_uc010plx.1_Missense_Mutation_p.L29F	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	327					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGAGTTTCTTCAAGAATGACA	0.323													0	0	0	0.000602	0	4	103										G	169993598	C	G	169993598	3	3	27	1	0	0	0	0	1	0	0	0	8311	825	29	1	1445	1	KIFAP3	1	169993598	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	11179768	169993598	79257023	31	7284										
FMO3	2328	broad.mit.edu	37	chr1	171083188	171083188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atttaacgatgagctcccagCaagcattctgtgtggcattg	10	9	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:171083188C>T	uc001ghi.2	+	7	980	c.869C>T	c.(868-870)GCA>GTA	p.A290V	FMO3_uc001ghh.2_Missense_Mutation_p.A290V|FMO3_uc010pmb.1_Missense_Mutation_p.A270V|FMO3_uc010pmc.1_Missense_Mutation_p.A227V	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	290					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAGCTCCCAGCAAGCATTCTG	0.433													0	0	0	0.005443	0	26	61										T	171083188	C	T	171083188	3	4	27	1	0	0	0	0	1	0	0	0	5956	710	25	2	891	2	FMO3	1	171083188	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1089590	171083188	78167433	32	7285										
CEP350	9857	broad.mit.edu	37	chr1	179989859	179989859	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccagcatagattcagtcagtGaagggcctcttcttagtgag	11	9	4	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:179989859G>A	uc001gnt.2	+	12	3333	c.2950G>A	c.(2950-2952)GAA>AAA	p.E984K	CEP350_uc009wxl.2_Missense_Mutation_p.E983K|CEP350_uc001gnu.2_Missense_Mutation_p.E818K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	984						centrosome|nucleus|spindle				ovary(4)	4						TTCAGTCAGTGAAGGGCCTCT	0.428													0	0	0	0.010729	0	11	182										A	179989859	G	A	179989859	3	1	27	1	0	0	0	0	1	0	0	0	3254	1291	45	1	2992	1	CEP350	1	179989859	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8906671	179989859	69260762	33	7286										
CEP350	9857	broad.mit.edu	37	chr1	179989968	179989968	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agaaaaggaattttgtcctgGagaaagaaatagttatgaac	10	3	0	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:179989968G>C	uc001gnt.2	+	12	3442	c.3059G>C	c.(3058-3060)GGA>GCA	p.G1020A	CEP350_uc009wxl.2_Missense_Mutation_p.G1019A|CEP350_uc001gnu.2_Missense_Mutation_p.G854A	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1020						centrosome|nucleus|spindle				ovary(4)	4						TTTTGTCCTGGAGAAAGAAAT	0.408													0	0	0	0.00308	0	8	77										C	179989968	G	C	179989968	3	2	27	1	0	0	0	0	1	0	0	0	3254	1174	41	1	3101	1	CEP350	1	179989968	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	109	179989968	69260653	34	7287										
HMCN1	83872	broad.mit.edu	37	chr1	186088322	186088322	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aacattttttttcatttttaGgagcaattgaaatacttgcc	5	6	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:186088322G>A	uc001grq.1	+	78	12078	c.11849_splice	c.e78-1	p.G3950_splice		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTCATTTTTAGGAGCAATTGA	0.373													0	0	0	0.003271	0	36	109										A	186088322	G	A	186088322	5	1	27	1	0	0	0	0	0	0	1	0	7220	1014	35	2	12158	2	HMCN1	1	186088322	Splice_Site	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	6098354	186088322	63162299	35	7288										
TPR	7175	broad.mit.edu	37	chr1	186319407	186319407	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acttggacttccatattactGaggtgctgtttcaatgtggc	10	8	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:186319407G>C	uc001grv.2	-	21	3021	c.2724C>G	c.(2722-2724)CTC>CTG	p.L908L		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	908	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CCATATTACTGAGGTGCTGTT	0.318			T	NTRK1	papillary thyroid								0	0	0	0.012319	0	19	100										C	186319407	G	C	186319407	2	2	27	1	0	0	0	0	0	0	0	1	16413	1277	45	1		1	TPR	1	186319407	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	231085	186319407	62931214	36	7289										
PTPRC	5788	broad.mit.edu	37	chr1	198701513	198701513	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaaaccgttatgttgacattCttccttgtgagtatttattg	7	6	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:198701513C>T	uc001gur.1	+	19	2233	c.2053C>T	c.(2053-2055)CTT>TTT	p.L685F	PTPRC_uc001gus.1_Missense_Mutation_p.L637F|PTPRC_uc001gut.1_Missense_Mutation_p.L524F|PTPRC_uc009wzf.1_Missense_Mutation_p.L573F|PTPRC_uc010ppg.1_Missense_Mutation_p.L621F	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	685	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGTTGACATTCTTCCTTGTGA	0.358													0	0	0	0.001168	0	6	72										T	198701513	C	T	198701513	3	4	27	1	0	0	0	0	1	0	0	0	12797	913	32	1	2134	1	PTPRC	1	198701513	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	12382106	198701513	50549108	37	7290										
IL20	50604	broad.mit.edu	37	chr1	207039849	207039849	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctgcgaatcgatgctgcctCctgcgccatttgctaagact	9	14	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:207039849C>A	uc001her.2	+	3	290	c.246C>A	c.(244-246)CTC>CTA	p.L82L	IL20_uc010pry.1_Silent_p.L153L|IL20_uc009xby.2_Silent_p.L82L	NM_018724	NP_061194	Q9NYY1	IL20_HUMAN	interleukin 20 precursor	82					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding				0	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		GATGCTGCCTCCTGCGCCATT	0.512													1	0	3.90053e-15	0.012213	4.22713e-15	30	541										A	207039849	C	A	207039849	2	1	27	1	0	0	0	0	0	0	0	1	7667	842	30	3		3	IL20	1	207039849	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	8338336	207039849	42210772	38	7291										
LAMB3	3914	broad.mit.edu	37	chr1	209823311	209823311	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgggaagtagggcctacctCgccatactgggtgcagtagg	15	10	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:209823311C>G	uc001hhg.2	-	2	571	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	LAMB3_uc009xco.2_Missense_Mutation_p.E61Q|LAMB3_uc001hhh.2_Missense_Mutation_p.E61Q|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.E61Q	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	61	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGGCCTACCTCGCCATACTGG	0.483													0	0	0	0.004672	0	3	55										G	209823311	C	G	209823311	3	3	27	1	0	0	0	0	1	0	0	0	8612	893	31	1	3421	1	LAMB3	1	209823311	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2783462	209823311	39427310	39	7292										
KCNK2	3776	broad.mit.edu	37	chr1	215256745	215256745	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctcatgcttcccagcgcctCgcgggagagacccggctata	11	16	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:215256745C>G	uc001hkq.2	+	1	186	c.17C>G	c.(16-18)TCG>TGG	p.S6W	KCNK2_uc001hko.2_Intron|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_Intron|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Intron	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	6	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCCAGCGCCTCGCGGGAGAGA	0.547													0	0	0	0.001984	0	5	85										G	215256745	C	G	215256745	3	3	27	1	0	0	0	0	1	0	0	0	8066	893	31	1	62	1	KCNK2	1	215256745	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5433434	215256745	33993876	40	7293										
USH2A	7399	broad.mit.edu	37	chr1	215963529	215963529	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcattttactggcaccgggtCattctttttaatatgtgctt	8	8	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:215963529C>T	uc001hku.1	-	51	10441	c.10054G>A	c.(10054-10056)GAC>AAC	p.D3352N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3352	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGCACCGGGTCATTCTTTTTA	0.403										HNSCC(13;0.011)			0	0	0	0.00308	0	8	170										T	215963529	C	T	215963529	3	4	27	1	0	0	0	0	1	0	0	0	17033	826	29	1	5642	1	USH2A	1	215963529	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	706784	215963529	33287092	41	7294										
CABC1	56997	broad.mit.edu	37	chr1	227171276	227171276	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctggcgtggcccagagcatCaacagtgatgtcaacaacct	10	13	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:227171276C>G	uc001hqm.1	+	14	4523	c.1104C>G	c.(1102-1104)ATC>ATG	p.I368M	CABC1_uc001hqn.1_Missense_Mutation_p.I368M|CABC1_uc009xeq.1_Missense_Mutation_p.I316M|CABC1_uc010pvq.1_Missense_Mutation_p.I89M|CABC1_uc010pvr.1_Missense_Mutation_p.I42M|CABC1_uc001hqo.1_Missense_Mutation_p.I89M|CABC1_uc009xer.1_Translation_Start_Site	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	368	Protein kinase.				cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CCCAGAGCATCAACAGTGATG	0.622													0	0	0	0.001168	0	6	73										G	227171276	C	G	227171276	3	3	27	1	0	0	0	0	1	0	0	0	2527	816	29	1	1134	1	CABC1	1	227171276	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	11207747	227171276	22079345	42	7295										
COG2	22796	broad.mit.edu	37	chr1	230795210	230795210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctctggttttatttttcagGaagatttcgatgtcgatcat	8	6	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:230795210G>A	uc001htw.2	+	2	224	c.73G>A	c.(73-75)GAA>AAA	p.E25K	COG2_uc001htx.2_Missense_Mutation_p.E25K|COG2_uc010pwc.1_5'UTR	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	25					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TATTTTTCAGGAAGATTTCGA	0.378													0	0	0	0.006214	0	10	103										A	230795210	G	A	230795210	3	1	27	1	0	0	0	0	1	0	0	0	3658	1188	41	1	79	1	COG2	1	230795210	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3623934	230795210	18455411	43	7296										
AHCTF1	25909	broad.mit.edu	37	chr1	247053281	247053281	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	actataccttgataaacgctCaaacttctgtcgacgactgg	7	11	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr1:247053281C>G	uc001ibu.1	-	16	2138	c.2131G>C	c.(2131-2133)GAG>CAG	p.E711Q	AHCTF1_uc001ibv.1_Missense_Mutation_p.E720Q|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	711	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GATAAACGCTCAAACTTCTGT	0.338													0	0	0	0.012319	0	19	221										G	247053281	C	G	247053281	3	3	27	1	0	0	0	0	1	0	0	0	408	835	29	1	4749	1	AHCTF1	1	247053281	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	16258071	247053281	2197340	44	7297										
LPIN1	23175	broad.mit.edu	37	chr2	11911647	11911647	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atcgctcccagcgagacgccGtcaagcagctctgtagtaaa	10	13	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:11911647G>A	uc010yjn.1	+	5	712	c.438G>A	c.(436-438)CCG>CCA	p.P146P	LPIN1_uc010yjm.1_Silent_p.P195P|LPIN1_uc002rbt.2_Silent_p.P146P|LPIN1_uc002rbs.2_Silent_p.P146P	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	146					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GCGAGACGCCGTCAAGCAGCT	0.537													0	0	0	0.004007	0	14	23										A	11911647	G	A	11911647	2	1	27	1	0	0	0	0	0	0	0	1	8918	1132	40	2		2	LPIN1	2	11911647	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08		11911647	231287726	45	7298										
PUM2	23369	broad.mit.edu	37	chr2	20478508	20478508	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgggtgctaggctgctactaGatcttttgtacaagtcagag	12	7	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:20478508G>C	uc002rds.1	-	12	1816	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	PUM2_uc002rdq.1_Translation_Start_Site|PUM2_uc002rdt.1_Missense_Mutation_p.S598C|PUM2_uc002rdr.2_Intron|PUM2_uc010yjy.1_Intron|PUM2_uc002rdu.1_Missense_Mutation_p.S598C|PUM2_uc010yjz.1_Missense_Mutation_p.S537C	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	598	Ser-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGCTACTAGATCTTTTGTA	0.438													0	0	0	0.009096	0	4	225										C	20478508	G	C	20478508	3	2	27	1	0	0	0	0	1	0	0	0	12826	942	33	1	1437	1	PUM2	2	20478508	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8566861	20478508	222720865	46	7299										
APOB	338	broad.mit.edu	37	chr2	21228021	21228021	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	caggactgtttcaacataatCtgctttgtttttcaaactgg	7	8	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:21228021C>T	uc002red.2	-	26	11847	c.11719G>A	c.(11719-11721)GAT>AAT	p.D3907N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3907					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAACATAATCTGCTTTGTTT	0.428													0	0	0	0.009718	0	44	129										T	21228021	C	T	21228021	3	4	27	1	0	0	0	0	1	0	0	0	785	913	32	1	1988	1	APOB	2	21228021	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	749513	21228021	221971352	47	7300										
ASXL2	55252	broad.mit.edu	37	chr2	25990452	25990452	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtctttgtaagcaaacttacTggtatggagtctctcagatc	9	8	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:25990452T>A	uc002rgs.2	-	7	996	c.775A>T	c.(775-777)AGA>TGA	p.R259*	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCAAACTTACTGGTATGGAGT	0.373													0	0	0	0.005443	0	28	73										A	25990452	T	A	25990452	4	1	27	1	0	0	0	0	0	1	0	0	1067	1594	55	5	3556	5	ASXL2	2	25990452	Nonsense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	4762431	25990452	217208921	48	7301										
CENPA	1058	broad.mit.edu	37	chr2	27016087	27016087	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	catgcaggccgagttactctCttcccaaaggatgtgcaact	9	12	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:27016087C>G	uc002rhr.2	+	4	546	c.363C>G	c.(361-363)CTC>CTG	p.L121L	CENPA_uc002rht.2_RNA|CENPA_uc002rhs.2_Silent_p.L95L	NM_001809	NP_001800	P49450	CENPA_HUMAN	centromere protein A isoform a	121	H3-like.				CenH3-containing nucleosome assembly at centromere|establishment of mitotic spindle orientation|interspecies interaction between organisms|kinetochore assembly|mitotic prometaphase|protein localization to chromosome, centromeric region	condensed nuclear chromosome kinetochore|cytosol|nucleoplasm|nucleosome	chromatin binding|DNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGTTACTCTCTTCCCAAAGG	0.542													0	0	0	0.01441	0	56	310										G	27016087	C	G	27016087	2	3	27	1	0	0	0	0	0	0	0	1	3226	900	32	1		1	CENPA	2	27016087	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1025635	27016087	216183286	49	7302										
C2orf53	339779	broad.mit.edu	37	chr2	27360613	27360613	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggatccttctcgcttggcacGcatctctccaccactccagg	8	17	2	0	rs137967723	byFrequency	TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:27360613G>A	uc002rjb.2	-	3	1165	c.585C>T	c.(583-585)TGC>TGT	p.C195C		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	195											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCTTGGCACGCATCTCTCCA	0.657													0	0	0	0.010729	0	10	51										A	27360613	G	A	27360613	2	1	27	1	0	0	0	0	0	0	0	1	2174	1079	38	2		2	C2orf53	2	27360613	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	344526	27360613	215838760	50	7303										
SUPT7L	9913	broad.mit.edu	37	chr2	27884232	27884232	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttctgttggtctggcttgatGatattggtatctctccccag	10	9	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:27884232G>A	uc002rlh.1	-	3	381	c.38C>T	c.(37-39)TCA>TTA	p.S13L	SUPT7L_uc002rli.1_Missense_Mutation_p.S13L|SUPT7L_uc010ymf.1_Intron|SUPT7L_uc002rlj.1_Missense_Mutation_p.S11L|SUPT7L_uc010ezh.1_Missense_Mutation_p.S11L|SLC4A1AP_uc002rlk.3_5'Flank	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	13					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					CTGGCTTGATGATATTGGTAT	0.448													0	0	0	0.006214	0	9	102										A	27884232	G	A	27884232	3	1	27	1	0	0	0	0	1	0	0	0	15398	1294	45	1	1222	1	SUPT7L	2	27884232	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	523619	27884232	215315141	51	7304										
HEATR5B	54497	broad.mit.edu	37	chr2	37287790	37287790	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agaatcgcctcgggccttctCagcttccaattcctttaagg	8	13	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:37287790C>G	uc002rpp.1	-	12	1879	c.1783G>C	c.(1783-1785)GAG>CAG	p.E595Q		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	595							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CGGGCCTTCTCAGCTTCCAAT	0.448													0	0	0	0.013537	0	13	130										G	37287790	C	G	37287790	3	3	27	1	0	0	0	0	1	0	0	0	7032	835	29	1	4532	1	HEATR5B	2	37287790	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9403558	37287790	205911583	52	7305										
THADA	63892	broad.mit.edu	37	chr2	43519295	43519295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	caagaactcctttggggtcaGatggacacagtgctccgtct	11	11	2	2	rs34600960		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:43519295G>C	uc002rsw.3	-	33	5237	c.4885C>G	c.(4885-4887)CTG>GTG	p.L1629V	THADA_uc010far.2_Missense_Mutation_p.L824V|THADA_uc002rsx.3_Missense_Mutation_p.L1629V|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1629							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TTTGGGGTCAGATGGACACAG	0.488													0	0	0	0.009096	0	3	17										C	43519295	G	C	43519295	3	2	27	1	0	0	0	0	1	0	0	0	15837	933	33	1	1000	1	THADA	2	43519295	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	6231505	43519295	199680078	53	7306										
NRXN1	9378	broad.mit.edu	37	chr2	50779755	50779755	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtctctctggaagtccacatGataccattctccatcattca	5	13	5	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:50779755G>A	uc010fbq.2	-	9	3326	c.1849C>T	c.(1849-1851)CAT>TAT	p.H617Y	NRXN1_uc002rxb.3_Missense_Mutation_p.H249Y|NRXN1_uc002rxe.3_Missense_Mutation_p.H577Y|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAGTCCACATGATACCATTCT	0.458													0	0	0	0.006214	0	8	173										A	50779755	G	A	50779755	3	1	27	1	0	0	0	0	1	0	0	0	10665	1290	45	1	3117	1	NRXN1	2	50779755	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	7260460	50779755	192419618	54	7307										
ETAA1	54465	broad.mit.edu	37	chr2	67637048	67637048	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgttgaatttttagaggaaGaagagaaaaatagaaagtgt	11	0	0	5			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:67637048G>C	uc002sdz.1	+	6	2798	c.2659G>C	c.(2659-2661)GAA>CAA	p.E887Q		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	887	Poly-Glu.					cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						TTTAGAGGAAGAAGAGAAAAA	0.333													0	0	0	0.001855	0	13	199										C	67637048	G	C	67637048	3	2	27	1	0	0	0	0	1	0	0	0	5267	943	33	1	2681	1	ETAA1	2	67637048	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	16857293	67637048	175562325	55	7308										
HTRA2	27429	broad.mit.edu	37	chr2	74757145	74757145	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcggagctgatggctgcgccGagggcggggcggggtgcagg	24	9	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:74757145G>A	uc002smi.1	+	1	614	c.12G>A	c.(10-12)CCG>CCA	p.P4P	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Silent_p.P4P|HTRA2_uc002smk.1_Silent_p.P4P|HTRA2_uc002sml.1_Silent_p.P4P|HTRA2_uc002smm.1_Intron|HTRA2_uc002smn.1_Intron|HTRA2_uc010ffl.2_5'Flank	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	4					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGGCTGCGCCGAGGGCGGGGC	0.741													0	0	0	0.004672	0	3	24										A	74757145	G	A	74757145	2	1	27	1	0	0	0	0	0	0	0	1	7454	1045	37	1		1	HTRA2	2	74757145	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	7120097	74757145	168442228	56	7309										
REV1	51455	broad.mit.edu	37	chr2	100019387	100019387	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aggaggtccttcatgttttaGaaacccatcaattaacttct	6	9	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:100019387G>A	uc002tad.2	-	20	3561	c.3349C>T	c.(3349-3351)CTA>TTA	p.L1117L	REV1_uc002tac.2_Silent_p.L1116L	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	1117					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						TCATGTTTTAGAAACCCATCA	0.408								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.013537	0	12	154										A	100019387	G	A	100019387	2	1	27	1	0	0	0	0	0	0	0	1	13239	933	33	1		1	REV1	2	100019387	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	25262242	100019387	143179986	57	7310										
MAP3K2	10746	broad.mit.edu	37	chr2	128066317	128066317	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctagtttgacgttgcctgttGaatctcgcaggatatttgcg	11	8	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:128066317G>C	uc002toj.1	-	15	1543	c.1478C>G	c.(1477-1479)TCA>TGA	p.S493*		NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	493	Protein kinase.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		GTTGCCTGTTGAATCTCGCAG	0.433													0	0	0	0.001855	0	13	146										C	128066317	G	C	128066317	4	2	27	1	0	0	0	0	0	1	0	0	9250	1294	45	1	389	1	MAP3K2	2	128066317	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	28046930	128066317	115133056	58	7311										
R3HDM1	23518	broad.mit.edu	37	chr2	136433011	136433011	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cccaacagcattggaaatcaGattcaaggagtggtcatccc	9	11	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:136433011G>C	uc002tuo.2	+	19	2527	c.2157G>C	c.(2155-2157)CAG>CAC	p.Q719H	R3HDM1_uc010fni.2_Missense_Mutation_p.Q718H|R3HDM1_uc002tup.2_Missense_Mutation_p.Q664H|R3HDM1_uc010zbh.1_Missense_Mutation_p.Q467H	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	719							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		TTGGAAATCAGATTCAAGGAG	0.423													0	0	0	0.010729	0	10	135										C	136433011	G	C	136433011	3	2	27	1	0	0	0	0	1	0	0	0	12887	933	33	1	2223	1	R3HDM1	2	136433011	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8366694	136433011	106766362	59	7312										
ZEB2	9839	broad.mit.edu	37	chr2	145157492	145157492	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcctaaagggctggtggctCcaagcccaccattcataaag	9	13	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:145157492C>T	uc002tvu.2	-	8	1742	c.1262G>A	c.(1261-1263)GGA>GAA	p.G421E	ZEB2_uc002tvv.2_Missense_Mutation_p.G415E|ZEB2_uc010zbm.1_Missense_Mutation_p.G392E|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.G450E	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	421						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCTGGTGGCTCCAAGCCCACC	0.453													0	0	0	0.004007	0	17	99										T	145157492	C	T	145157492	3	4	27	1	0	0	0	0	1	0	0	0	17621	855	30	1	2394	1	ZEB2	2	145157492	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	8724481	145157492	98041881	60	7313										
TANC1	85461	broad.mit.edu	37	chr2	160035372	160035372	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cccgtgtctctctctgagctCtatttgcttcagtgcaacat	7	13	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:160035372C>T	uc002uag.2	+	14	2482	c.2208C>T	c.(2206-2208)CTC>CTT	p.L736L	TANC1_uc010fol.1_Silent_p.L630L|TANC1_uc010zcm.1_Silent_p.L728L|TANC1_uc010fom.1_Silent_p.L542L|TANC1_uc002uai.1_RNA	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	736						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TCTCTGAGCTCTATTTGCTTC	0.552													0	0	0	0.008361	0	29	268										T	160035372	C	T	160035372	2	4	27	1	0	0	0	0	0	0	0	1	15541	900	32	1		1	TANC1	2	160035372	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	14877880	160035372	83164001	61	7314										
BAZ2B	29994	broad.mit.edu	37	chr2	160295645	160295645	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgaatcactgctactaatgcCttcacttgaggtgtctgatg	9	9	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:160295645C>T	uc002uao.2	-	7	1127	c.775G>A	c.(775-777)GGC>AGC	p.G259S	BAZ2B_uc002uap.2_Missense_Mutation_p.G257S|BAZ2B_uc002uas.1_Missense_Mutation_p.G196S|BAZ2B_uc002uau.1_Missense_Mutation_p.G257S|BAZ2B_uc002uaq.1_Missense_Mutation_p.G187S|BAZ2B_uc002uat.3_Missense_Mutation_p.G196S|BAZ2B_uc010fop.1_Missense_Mutation_p.G257S	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	259	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTACTAATGCCTTCACTTGAG	0.348													0	0	0	0.013726	0	35	235										T	160295645	C	T	160295645	3	4	27	1	0	0	0	0	1	0	0	0	1332	681	24	2	5855	2	BAZ2B	2	160295645	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	260273	160295645	82903728	62	7315										
C2orf77	129881	broad.mit.edu	37	chr2	170502533	170502533	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttcctgtacagcttttacaaGagggtaaatatatttatttg	7	5	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:170502533G>C	uc002ufe.2	-	9	1571	c.1477C>G	c.(1477-1479)CTT>GTT	p.L493V		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	493											0						GCTTTTACAAGAGGGTAAATA	0.433													0	0	0	0.01441	0	71	174										C	170502533	G	C	170502533	3	2	27	1	0	0	0	0	1	0	0	0	2194	942	33	1	185	1	C2orf77	2	170502533	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	10206888	170502533	72696840	63	7316										
TTN	7273	broad.mit.edu	37	chr2	179397871	179397871	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgtgtcagtggtacactttCagttccagaaagaatttcag	9	8	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:179397871C>G	uc010zfg.1	-	307	95991	c.95767G>C	c.(95767-95769)GAA>CAA	p.E31923Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25618Q|TTN_uc010zfi.1_Missense_Mutation_p.E25551Q|TTN_uc010zfj.1_Missense_Mutation_p.E25426Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32850							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTACACTTTCAGTTCCAGAA	0.433													0	0	0	0.00245	0	15	206										G	179397871	C	G	179397871	3	3	27	1	0	0	0	0	1	0	0	0	16732	835	29	1	4528	1	TTN	2	179397871	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	8895338	179397871	63801502	64	7317										
TTN	7273	broad.mit.edu	37	chr2	179477688	179477688	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagtcttcagcatttcaatgAcataagactcaatctttgca	5	10	5	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:179477688A>G	uc010zfg.1	-	214	42280	c.42056T>C	c.(42055-42057)GTC>GCC	p.V14019A	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V7714A|TTN_uc010zfi.1_Missense_Mutation_p.V7647A|TTN_uc010zfj.1_Missense_Mutation_p.V7522A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14946							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTCAATGACATAAGACTC	0.478													0	0	0	0.00308	0	8	62										G	179477688	A	G	179477688	3	3	27	1	0	0	0	0	1	0	0	0	16732	275	10	5	58325	5	TTN	2	179477688	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	79817	179477688	63721685	65	7318										
DNER	92737	broad.mit.edu	37	chr2	230312236	230312236	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcaggggtccaccttttcttCacaagcagatccgaagtatc	9	12	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:230312236C>T	uc002vpv.2	-	8	1429	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	DNER_uc010zly.1_Missense_Mutation_p.E156K	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	428	Extracellular (Potential).|EGF-like 5.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		ACCTTTTCTTCACAAGCAGAT	0.483													0	0	0	0.009096	0	4	31										T	230312236	C	T	230312236	3	4	27	1	0	0	0	0	1	0	0	0	4667	835	29	1	955	1	DNER	2	230312236	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	50834548	230312236	12887137	66	7319										
RBM44	375316	broad.mit.edu	37	chr2	238726510	238726510	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	caatctaagagtggttccttGagccctcaaaaagtattaaa	7	8	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr2:238726510G>C	uc002vxi.3	+	3	1083	c.951G>C	c.(949-951)TTG>TTC	p.L317F		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	316							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		GTGGTTCCTTGAGCCCTCAAA	0.318													0	0	0	0.001168	0	6	48										C	238726510	G	C	238726510	3	2	27	1	0	0	0	0	1	0	0	0	13138	1281	45	1	957	1	RBM44	2	238726510	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8414274	238726510	4472863	67	7320										
CNTN6	27255	broad.mit.edu	37	chr3	1418703	1418703	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttttagtccctgttgtggcaCcagtaaacatccatggaggt	10	9	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:1418703C>T	uc003boz.2	+	17	2377	c.2110C>T	c.(2110-2112)CCA>TCA	p.P704S	CNTN6_uc011asj.1_Missense_Mutation_p.P632S|CNTN6_uc003bpa.2_Missense_Mutation_p.P704S	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	704	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGTTGTGGCACCAGTAAACAT	0.378													0	0	0	0.004482	0	8	211										T	1418703	C	T	1418703	3	4	27	1	0	0	0	0	1	0	0	0	3645	507	18	2	2172	2	CNTN6	3	1418703	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		1418703	196603727	68	7321										
HRH1	3269	broad.mit.edu	37	chr3	11301597	11301597	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccccagttgtcttcagccaaGaggatgatagagaagtagac	11	9	2	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:11301597G>A	uc010hdr.2	+	2	1216	c.874G>A	c.(874-876)GAG>AAG	p.E292K	HRH1_uc010hds.2_Missense_Mutation_p.E292K|HRH1_uc010hdt.2_Missense_Mutation_p.E292K|HRH1_uc003bwb.3_Missense_Mutation_p.E292K	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	292	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CTTCAGCCAAGAGGATGATAG	0.493													0	0	0	0.00308	0	8	127										A	11301597	G	A	11301597	3	1	27	1	0	0	0	0	1	0	0	0	7355	943	33	1	876	1	HRH1	3	11301597	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9882894	11301597	186720833	69	7322										
IQSEC1	9922	broad.mit.edu	37	chr3	12977699	12977699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagtttgcggtggtccatgcCgtgcagggctgtctggggtt	17	9	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:12977699C>T	uc003bxt.2	-	3	868	c.859G>A	c.(859-861)GGC>AGC	p.G287S	IQSEC1_uc003bxu.3_Missense_Mutation_p.G165S|IQSEC1_uc011auw.1_Missense_Mutation_p.G273S	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	287					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						TGGTCCATGCCGTGCAGGGCT	0.662													0	0	0	0.010729	0	12	97										T	12977699	C	T	12977699	3	4	27	1	0	0	0	0	1	0	0	0	7817	652	23	2	2625	2	IQSEC1	3	12977699	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1676102	12977699	185044731	70	7323										
FGD5	152273	broad.mit.edu	37	chr3	14861786	14861786	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtgtggctccctacagggtgGagcggccgagggtcccgcag	18	12	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:14861786G>C	uc003bzc.2	+	1	1318	c.1208G>C	c.(1207-1209)GGA>GCA	p.G403A	FGD5_uc011avk.1_Missense_Mutation_p.G403A	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	403					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CTACAGGGTGGAGCGGCCGAG	0.632													0	0	0	0.004672	0	3	27										C	14861786	G	C	14861786	3	2	27	1	0	0	0	0	1	0	0	0	5836	1174	41	1	1210	1	FGD5	3	14861786	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1884087	14861786	183160644	71	7324										
SUSD5	26032	broad.mit.edu	37	chr3	33194715	33194715	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgaatctccagggtagagttGactggtacttcgtcaagtca	11	8	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:33194715G>C	uc003cfo.1	-	5	1827	c.1409C>G	c.(1408-1410)TCA>TGA	p.S470*		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	470	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						GGGTAGAGTTGACTGGTACTT	0.517													0	0	0	0.004672	0	3	61										C	33194715	G	C	33194715	4	2	27	1	0	0	0	0	0	1	0	0	15408	1294	45	1	484	1	SUSD5	3	33194715	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	18332929	33194715	164827715	72	7325										
TRANK1	9881	broad.mit.edu	37	chr3	36874809	36874809	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaccagactgaggaggatttCcaagccccctggagccaggc	13	13	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:36874809C>T	uc003cgj.2	-	12	4785	c.4483G>A	c.(4483-4485)GAA>AAA	p.E1495K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2045					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGGAGGATTTCCAAGCCCCCT	0.532													0	0	0	0.001984	0	6	91										T	36874809	C	T	36874809	3	4	27	1	0	0	0	0	1	0	0	0	16451	864	30	1	2656	1	TRANK1	3	36874809	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3680094	36874809	161147621	73	7326										
SETD2	29072	broad.mit.edu	37	chr3	47158213	47158213	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtacactcacactgcattcGcttaatatctcgatgagatt	6	10	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:47158213G>A	uc003cqs.2	-	4	4539	c.4486C>T	c.(4486-4488)CGA>TGA	p.R1496*	SETD2_uc003cqv.2_Nonsense_Mutation_p.R1485*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1496	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CACTGCATTCGCTTAATATCT	0.313			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.010729	0	12	139										A	47158213	G	A	47158213	4	1	27	1	0	0	0	0	0	1	0	0	14131	1095	38	2	3280	2	SETD2	3	47158213	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	10283404	47158213	150864217	74	7327										
COL7A1	1294	broad.mit.edu	37	chr3	48609570	48609570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cccacctcaccttctcgcctCgcggccctggcagtcctcgg	9	21	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:48609570C>T	uc003ctz.2	-	90	7014	c.7013G>A	c.(7012-7014)CGA>CAA	p.R2338Q		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2338	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTTCTCGCCTCGCGGCCCTGG	0.612													0	0	0	0.004482	0	7	30										T	48609570	C	T	48609570	3	4	27	1	0	0	0	0	1	0	0	0	3704	884	31	1	1937	1	COL7A1	3	48609570	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1451357	48609570	149412860	75	7328										
ZMYND10	51364	broad.mit.edu	37	chr3	50379109	50379109	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccactgcctctagcacatcCagcctgtaggtctcagccca	8	17	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:50379109C>T	uc003dag.1	-	11	1289	c.1143G>A	c.(1141-1143)CTG>CTA	p.L381L	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Silent_p.L376L	NM_015896	NP_056980	O75800	ZMY10_HUMAN	zinc finger, MYND domain-containing 10	381						cytoplasm	protein binding|zinc ion binding			lung(4)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		CTAGCACATCCAGCCTGTAGG	0.612										TSP Lung(30;0.18)			0	0	0	0.007413	0	12	67										T	50379109	C	T	50379109	2	4	27	1	0	0	0	0	0	0	0	1	17702	581	21	2		2	ZMYND10	3	50379109	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1769539	50379109	147643321	76	7329										
STAB1	23166	broad.mit.edu	37	chr3	52547984	52547984	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcctgccttcagcctcttccGggaattgctgcaggtacgga	12	13	2	0	rs149300853		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:52547984G>T	uc003dej.2	+	32	3508	c.3434G>T	c.(3433-3435)CGG>CTG	p.R1145L		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1145	FAS1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AGCCTCTTCCGGGAATTGCTG	0.652													1	0	1.49906e-05	0.00245	1.57193e-05	11	171										T	52547984	G	T	52547984	3	4	27	1	0	0	0	0	1	0	0	0	15236	1116	39	4	3560	4	STAB1	3	52547984	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2168875	52547984	145474446	77	7330										
PDE12	201626	broad.mit.edu	37	chr3	57543244	57543244	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtttcgaatcaagcagcacGaaggcctggccactttctac	9	12	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:57543244G>A	uc003diw.3	+	1	1264	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	PDE12_uc003div.2_Missense_Mutation_p.E380K	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	380							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		CAAGCAGCACGAAGGCCTGGC	0.537													0	0	0	0.009096	0	4	74										A	57543244	G	A	57543244	3	1	27	1	0	0	0	0	1	0	0	0	11632	1059	37	1	1140	1	PDE12	3	57543244	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4995260	57543244	140479186	78	7331										
FLNB	2317	broad.mit.edu	37	chr3	57994493	57994493	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcatgtaccgcaagtaccatCagcggcccacctttcgccag	9	16	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:57994493C>G	uc003djj.2	+	1	367	c.202C>G	c.(202-204)CAG>GAG	p.Q68E	FLNB_uc010hne.2_Missense_Mutation_p.Q68E|FLNB_uc003djk.2_Missense_Mutation_p.Q68E|FLNB_uc010hnf.2_Missense_Mutation_p.Q68E	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	68	Actin-binding.|CH 1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CAAGTACCATCAGCGGCCCAC	0.617													0	0	0	0.001168	0	5	124										G	57994493	C	G	57994493	3	3	27	1	0	0	0	0	1	0	0	0	5934	827	29	1	204	1	FLNB	3	57994493	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	451249	57994493	140027937	79	7332										
PXK	54899	broad.mit.edu	37	chr3	58377546	58377546	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtcagataaagattttcagtGtctaatcaaacttctgcctt	6	8	5	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:58377546G>A	uc003djz.1	+	7	686	c.587G>A	c.(586-588)TGT>TAT	p.C196Y	PXK_uc003djx.1_Missense_Mutation_p.C196Y|PXK_uc003djy.1_Missense_Mutation_p.C179Y|PXK_uc003dka.1_Missense_Mutation_p.C196Y|PXK_uc003dkb.1_Missense_Mutation_p.C113Y|PXK_uc003dkc.1_Missense_Mutation_p.C179Y|PXK_uc011bfe.1_Missense_Mutation_p.C163Y|PXK_uc010hnj.1_Missense_Mutation_p.C163Y|PXK_uc003dkd.1_Missense_Mutation_p.C59Y|PXK_uc010hnk.1_Intron	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	196	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		GATTTTCAGTGTCTAATCAAA	0.383													0	0	0	0.014323	0	20	233										A	58377546	G	A	58377546	3	1	27	1	0	0	0	0	1	0	0	0	12849	1377	48	2	613	2	PXK	3	58377546	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	383053	58377546	139644884	80	7333										
ACOX2	8309	broad.mit.edu	37	chr3	58508267	58508267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agtggtctggttccaagcctCgtgctggtcagctccggatt	13	11	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:58508267C>T	uc003dkl.2	-	12	1763	c.1588G>A	c.(1588-1590)GAG>AAG	p.E530K		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	acyl-Coenzyme A oxidase 2	530					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		TTCCAAGCCTCGTGCTGGTCA	0.532													0	0	0	0.005443	0	23	75										T	58508267	C	T	58508267	3	4	27	1	0	0	0	0	1	0	0	0	159	893	31	1	473	1	ACOX2	3	58508267	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	130721	58508267	139514163	81	7334										
ATXN7	6314	broad.mit.edu	37	chr3	63938123	63938123	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tggtgtgtaacgactgtaatCaggttgtcaaaccgcaggca	12	8	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:63938123C>T	uc003dlw.3	+	5	1016	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	ATXN7_uc003dlv.2_Nonsense_Mutation_p.Q155*|ATXN7_uc010hnv.2_Nonsense_Mutation_p.Q155*	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	155					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CGACTGTAATCAGGTTGTCAA	0.373													0	0	0	0.00245	0	14	175										T	63938123	C	T	63938123	4	4	27	1	0	0	0	0	0	1	0	0	1215	827	29	1	473	1	ATXN7	3	63938123	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5429856	63938123	134084307	82	7335										
ATXN7	6314	broad.mit.edu	37	chr3	63975994	63975994	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcgaaggcgatgacaaagaaGagtctgttgaaaaactggac	13	6	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:63975994G>A	uc003dlw.3	+	10	2057	c.1504G>A	c.(1504-1506)GAG>AAG	p.E502K	ATXN7_uc003dlv.2_Missense_Mutation_p.E502K|ATXN7_uc010hnv.2_Missense_Mutation_p.E502K|ATXN7_uc011bfn.1_Missense_Mutation_p.E357K	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	502					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TGACAAAGAAGAGTCTGTTGA	0.552													0	0	0	0.001168	0	5	103										A	63975994	G	A	63975994	3	1	27	1	0	0	0	0	1	0	0	0	1215	943	33	1	1602	1	ATXN7	3	63975994	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	37871	63975994	134046436	83	7336										
C3orf64	285203	broad.mit.edu	37	chr3	69027583	69027583	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagcgttcatcttcacagttGtacctaaggacacaagggtg	10	10	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:69027583G>A	uc003dnl.2	-	17	1743	c.1338C>T	c.(1336-1338)TAC>TAT	p.Y446Y	C3orf64_uc003dnj.2_Silent_p.Y125Y|C3orf64_uc003dnk.2_Silent_p.Y362Y|C3orf64_uc011bfw.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	446						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		CTTCACAGTTGTACCTAAGGA	0.453													0	0	0	0.010729	0	12	138										A	69027583	G	A	69027583	2	1	27	1	0	0	0	0	0	0	0	1	2240	1372	48	2		2	C3orf64	3	69027583	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5051589	69027583	128994847	84	7337										
FOXP1	27086	broad.mit.edu	37	chr3	71050197	71050197	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctatcgtccagcgcatgctCactgttgagatgtctgcaac	9	12	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:71050197C>G	uc003dol.2	-	9	1311	c.988G>C	c.(988-990)GAG>CAG	p.E330Q	FOXP1_uc003dom.2_Missense_Mutation_p.E254Q|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Missense_Mutation_p.E330Q|FOXP1_uc003dop.2_Missense_Mutation_p.E330Q|FOXP1_uc003doq.1_Missense_Mutation_p.E329Q|FOXP1_uc003doi.2_Missense_Mutation_p.E230Q|FOXP1_uc003doj.2_Missense_Mutation_p.E230Q|FOXP1_uc003dok.2_Missense_Mutation_p.E143Q|FOXP1_uc003dor.1_Missense_Mutation_p.E108Q	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	330	C2H2-type.				cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		AGCGCATGCTCACTGTTGAGA	0.353			T	PAX5	ALL								0	0	0	0.008291	0	9	123										G	71050197	C	G	71050197	3	3	27	1	0	0	0	0	1	0	0	0	6026	835	29	1	1081	1	FOXP1	3	71050197	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2022614	71050197	126972233	85	7338										
OR5K2	402135	broad.mit.edu	37	chr3	98216586	98216586	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cacaggatttacagatcaccCtgagctgaagactctgctgt	9	11	2	4	rs143260385	byFrequency	TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:98216586C>T	uc011bgx.1	+	1	62	c.62C>T	c.(61-63)CCT>CTT	p.P21L		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						ACAGATCACCCTGAGCTGAAG	0.413													0	0	0	0.00245	0	14	256										T	98216586	C	T	98216586	3	4	27	1	0	0	0	0	1	0	0	0	11167	681	24	2	64	2	OR5K2	3	98216586	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	27166389	98216586	99805844	86	7339										
MYH15	22989	broad.mit.edu	37	chr3	108129603	108129603	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agtcggcaagggccttgccaGactgcagctgcttctggtcc	13	13	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:108129603G>C	uc003dxa.1	-	32	4439	c.4382C>G	c.(4381-4383)TCT>TGT	p.S1461C		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1461	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GGCCTTGCCAGACTGCAGCTG	0.632													0	0	0	0.001168	0	5	67										C	108129603	G	C	108129603	3	2	27	1	0	0	0	0	1	0	0	0	10034	942	33	1	1502	1	MYH15	3	108129603	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9913017	108129603	89892827	87	7340										
DPPA4	55211	broad.mit.edu	37	chr3	109050829	109050829	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggagggattggtatcttcttCtgaggtctggggttgtcagt	16	5	5	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:109050829C>T	uc003dxq.3	-	3	283	c.228G>A	c.(226-228)CAG>CAA	p.Q76Q	DPPA4_uc011bho.1_Silent_p.Q76Q|DPPA4_uc011bhp.1_Silent_p.Q76Q	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	76						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GTATCTTCTTCTGAGGTCTGG	0.458													0	0	0	0.004289	0	35	228										T	109050829	C	T	109050829	2	4	27	1	0	0	0	0	0	0	0	1	4736	912	32	1		1	DPPA4	3	109050829	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	921226	109050829	88971601	88	7341										
GOLGB1	2804	broad.mit.edu	37	chr3	121412961	121412961	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cttctctttcaggtgcttctCttctgcctgttccagtcttc	6	14	5	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:121412961C>G	uc003eei.3	-	13	6520	c.6394G>C	c.(6394-6396)GAG>CAG	p.E2132Q	GOLGB1_uc010hrc.2_Missense_Mutation_p.E2137Q|GOLGB1_uc003eej.3_Missense_Mutation_p.E2098Q|GOLGB1_uc011bjm.1_Missense_Mutation_p.E2018Q|GOLGB1_uc010hrd.1_Missense_Mutation_p.E2096Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2132	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGGTGCTTCTCTTCTGCCTGT	0.398													0	0	0	0.01441	0	72	577										G	121412961	C	G	121412961	3	3	27	1	0	0	0	0	1	0	0	0	6565	922	32	1	3425	1	GOLGB1	3	121412961	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	12362132	121412961	76609469	89	7342										
GOLGB1	2804	broad.mit.edu	37	chr3	121413280	121413280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgatacctgatgcagtccttCtgtagctgctttacttcttg	8	10	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:121413280C>T	uc003eei.3	-	13	6201	c.6075G>A	c.(6073-6075)CAG>CAA	p.Q2025Q	GOLGB1_uc010hrc.2_Silent_p.Q2030Q|GOLGB1_uc003eej.3_Silent_p.Q1991Q|GOLGB1_uc011bjm.1_Silent_p.Q1911Q|GOLGB1_uc010hrd.1_Silent_p.Q1989Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2025	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGCAGTCCTTCTGTAGCTGCT	0.358													0	0	0	0.009535	0	31	363										T	121413280	C	T	121413280	2	4	27	1	0	0	0	0	0	0	0	1	6565	912	32	1		1	GOLGB1	3	121413280	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	319	121413280	76609150	90	7343										
KPNA1	3836	broad.mit.edu	37	chr3	122186201	122186201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	catgttactaatctgagcctCatgaaagcctccatctgaca	6	12	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:122186201C>T	uc003efd.1	-	3	241	c.205G>A	c.(205-207)GAG>AAG	p.E69K	KPNA1_uc011bjr.1_5'UTR|KPNA1_uc010hrh.2_5'UTR|KPNA1_uc003efe.2_Missense_Mutation_p.E69K	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	69					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		ATCTGAGCCTCATGAAAGCCT	0.363													0	0	0	0.00308	0	8	95										T	122186201	C	T	122186201	3	4	27	1	0	0	0	0	1	0	0	0	8429	835	29	1	1459	1	KPNA1	3	122186201	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	772921	122186201	75836229	91	7344										
PDIA5	10954	broad.mit.edu	37	chr3	122811201	122811201	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttttttgttttttttttacaGaggtggcagctgaaaatcat	8	4	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:122811201G>A	uc003egc.1	+	3	226	c.170_splice	c.e3-1	p.E57_splice	PDIA5_uc003egd.1_Splice_Site	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor						cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		TTTTTTTACAGAGGTGGCAGC	0.502													0	0	0	0.006214	0	10	104										A	122811201	G	A	122811201	5	1	27	1	0	0	0	0	0	0	1	0	11671	956	33	1	179	1	PDIA5	3	122811201	Splice_Site	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	625000	122811201	75211229	92	7345										
PLSCR5	389158	broad.mit.edu	37	chr3	146311797	146311797	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctgagttatctgtgatcctCagggtgcaagatcgcagagt	12	9	2	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:146311797C>T	uc003ewb.2	-	4	1367	c.363G>A	c.(361-363)CTG>CTA	p.L121L	PLSCR5_uc010hvb.2_Silent_p.L109L|PLSCR5_uc010hvc.2_Silent_p.L121L	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	121											0						CTGTGATCCTCAGGGTGCAAG	0.453													0	0	0	0.008291	0	11	223										T	146311797	C	T	146311797	2	4	27	1	0	0	0	0	0	0	0	1	12113	813	29	1		1	PLSCR5	3	146311797	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	23500596	146311797	51710633	93	7346										
SAMD7	344658	broad.mit.edu	37	chr3	169644760	169644760	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agcacccagcaaccagaagtCaagtgaaacgaatgaaaagc	9	10	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:169644760C>T	uc003fgd.2	+	6	977	c.710C>T	c.(709-711)TCA>TTA	p.S237L	SAMD7_uc003fge.2_Missense_Mutation_p.S237L|SAMD7_uc011bpo.1_Missense_Mutation_p.S138L	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	237										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AACCAGAAGTCAAGTGAAACG	0.498													0	0	0	0.012319	0	22	124										T	169644760	C	T	169644760	3	4	27	1	0	0	0	0	1	0	0	0	13824	838	29	1	724	1	SAMD7	3	169644760	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	23332963	169644760	28377670	94	7347										
SPATA16	83893	broad.mit.edu	37	chr3	172643146	172643146	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatgatttacctgtgaatatCggcagcttcctgcttgatat	9	8	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:172643146C>G	uc003fin.3	-	7	1376	c.1218G>C	c.(1216-1218)CCG>CCC	p.P406P		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	406					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			CTGTGAATATCGGCAGCTTCC	0.373													0	0	0	0.004672	0	3	92										G	172643146	C	G	172643146	2	3	27	1	0	0	0	0	0	0	0	1	15000	871	31	1		1	SPATA16	3	172643146	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2998386	172643146	25379284	95	7348										
USP13	8975	broad.mit.edu	37	chr3	179448467	179448467	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctccggtgaaatctgaactCattgaacaggtgatgaagga	11	8	2	5			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:179448467C>G	uc003fkh.2	+	10	1305	c.1224C>G	c.(1222-1224)CTC>CTG	p.L408L	USP13_uc003fkf.2_Silent_p.L408L	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	408					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			AATCTGAACTCATTGAACAGG	0.468													0	0	0	0.008291	0	8	95										G	179448467	C	G	179448467	2	3	27	1	0	0	0	0	0	0	0	1	17041	813	29	1		1	USP13	3	179448467	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6805321	179448467	18573963	96	7349										
PEX5L	51555	broad.mit.edu	37	chr3	179526147	179526147	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aacagaacccctagacctgtCtgcaggtctgggtcgatcat	10	12	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:179526147C>G	uc003fki.1	-	13	1561	c.1431G>C	c.(1429-1431)CAG>CAC	p.Q477H	PEX5L_uc011bqd.1_Missense_Mutation_p.Q434H|PEX5L_uc011bqe.1_Missense_Mutation_p.Q285H|PEX5L_uc011bqf.1_Missense_Mutation_p.Q369H|PEX5L_uc003fkj.1_Missense_Mutation_p.Q442H|PEX5L_uc010hxd.1_Missense_Mutation_p.Q475H|PEX5L_uc011bqg.1_Missense_Mutation_p.Q453H|PEX5L_uc011bqh.1_Missense_Mutation_p.Q418H	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	477	TPR 3.				protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CTAGACCTGTCTGCAGGTCTG	0.443													0	0	0	0.010729	0	11	159										G	179526147	C	G	179526147	3	3	27	1	0	0	0	0	1	0	0	0	11749	912	32	1	461	1	PEX5L	3	179526147	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	77680	179526147	18496283	97	7350										
KLHL6	89857	broad.mit.edu	37	chr3	183217456	183217456	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcactctccagctcatgctCtgttagcgggagcttggcca	10	14	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:183217456C>G	uc003flr.2	-	4	1127	c.1069G>C	c.(1069-1071)GAG>CAG	p.E357Q	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Intron	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	357	Kelch 1.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			AGCTCATGCTCTGTTAGCGGG	0.552													0	0	0	0.004007	0	15	218										G	183217456	C	G	183217456	3	3	27	1	0	0	0	0	1	0	0	0	8393	922	32	1	812	1	KLHL6	3	183217456	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3691309	183217456	14804974	98	7351										
TRA2B	6434	broad.mit.edu	37	chr3	185636158	185636158	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagataaaaacttacgaggtGagtatgatcgagatctggaa	11	4	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr3:185636158G>A	uc003fpv.2	-	8	1127	c.851C>T	c.(850-852)TCA>TTA	p.S284L	TRA2B_uc003fpt.2_RNA|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Missense_Mutation_p.S184L|TRA2B_uc003fpw.2_Missense_Mutation_p.S264L	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	284	Arg/Ser-rich (RS2 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						CTTACGAGGTGAGTATGATCG	0.378													0	0	0	0.004482	0	8	167										A	185636158	G	A	185636158	3	1	27	1	0	0	0	0	1	0	0	0	16431	1294	45	1	23	1	TRA2B	3	185636158	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2418702	185636158	12386272	99	7352										
ZNF595	152687	broad.mit.edu	37	chr4	87139	87139	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atcctcaacccttactaaacAtaagagaattcatactggag	5	10	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:87139A>G	uc003fzv.1	+	6	1901	c.1745A>G	c.(1744-1746)CAT>CGT	p.H582R	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.H350R|ZNF595_uc011but.1_Missense_Mutation_p.H350R	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	582					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		CTTACTAAACATAAGAGAATT	0.373													0	0	0	0.006122	0	19	49										G	87139	A	G	87139	3	3	27	1	0	0	0	0	1	0	0	0	18022	217	8	5	1758	5	ZNF595	4	87139	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08		87139	191067137	100	7353										
WHSC1	7468	broad.mit.edu	37	chr4	1980413	1980413	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgacgtgtgtggcaaaccttCgacttcattttgccacctct	8	12	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:1980413C>T	uc003gdz.3	+	22	4051	c.3875C>T	c.(3874-3876)TCG>TTG	p.S1292L	WHSC1_uc003geb.3_Missense_Mutation_p.S1292L|WHSC1_uc003gec.3_Missense_Mutation_p.S1292L|WHSC1_uc003ged.3_Missense_Mutation_p.S1292L|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.S511L|WHSC1_uc011bvh.1_Missense_Mutation_p.S353L|WHSC1_uc010icf.2_Missense_Mutation_p.S640L	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1292					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGCAAACCTTCGACTTCATTT	0.542			T	IGH@	MM								0	0	0	0.010729	0	12	89										T	1980413	C	T	1980413	3	4	27	1	0	0	0	0	1	0	0	0	17359	893	31	1	4033	1	WHSC1	4	1980413	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1893274	1980413	189173863	101	7354										
KIAA0232	9778	broad.mit.edu	37	chr4	6873346	6873346	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaggaatgaatagaagtcaaGaaaaacagacctggtgggaa	12	4	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:6873346G>A	uc003gjr.3	+	8	4310	c.3847G>A	c.(3847-3849)GAA>AAA	p.E1283K	KIAA0232_uc003gjq.3_Missense_Mutation_p.E1283K	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	1283							ATP binding			ovary(2)	2						TAGAAGTCAAGAAAAACAGAC	0.353													0	0	0	0.003163	0	15	107										A	6873346	G	A	6873346	3	1	27	1	0	0	0	0	1	0	0	0	8163	943	33	1	3869	1	KIAA0232	4	6873346	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4892933	6873346	184280930	102	7355										
TLR6	10333	broad.mit.edu	37	chr4	38831092	38831092	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ataggttctttgtctttggtCatgatgttgcagtggctatc	11	6	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:38831092C>T	uc003gtm.2	-	1	69	c.3G>A	c.(1-3)ATG>ATA	p.M1I	TLR6_uc010ifg.1_Missense_Mutation_p.M1I	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	1					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						TGTCTTTGGTCATGATGTTGC	0.343													0	0	0	0.000602	0	5	165										T	38831092	C	T	38831092	3	4	27	1	0	0	0	0	1	0	0	0	15952	826	29	1	2391	1	TLR6	4	38831092	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	31957746	38831092	152323184	103	7356										
PDS5A	23244	broad.mit.edu	37	chr4	39905710	39905710	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgcagaagtttgtcctttatCcagctgactttctctgcagc	8	11	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:39905710C>T	uc003guv.3	-	12	1875	c.1335G>A	c.(1333-1335)TGG>TGA	p.W445*	PDS5A_uc010ifo.2_Nonsense_Mutation_p.W405*|PDS5A_uc003guw.3_Nonsense_Mutation_p.W445*	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	445					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						TGTCCTTTATCCAGCTGACTT	0.383													0	0	0	0.009096	0	3	34										T	39905710	C	T	39905710	4	4	27	1	0	0	0	0	0	1	0	0	11691	856	30	1	2799	1	PDS5A	4	39905710	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1074618	39905710	151248566	104	7357										
PPBP	5473	broad.mit.edu	37	chr4	74853297	74853297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccaaactttggatgtttttgGgatgaattccagaggttgtc	11	6	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:74853297G>A	uc003hhj.2	-	2	301	c.221C>T	c.(220-222)CCC>CTC	p.P74L		NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor	74					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			GATGTTTTTGGGATGAATTCC	0.393													0	0	0	0.00632	0	27	72										A	74853297	G	A	74853297	3	1	27	1	0	0	0	0	1	0	0	0	12303	1232	43	2	173	2	PPBP	4	74853297	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	34947587	74853297	116300979	105	7358										
CNOT6L	246175	broad.mit.edu	37	chr4	78663304	78663304	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccttaacttacttttctgttTtgaagaatattgcacaacca	4	9	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:78663304T>C	uc011ccd.1	-	8	994	c.863A>G	c.(862-864)AAA>AGA	p.K288R	CNOT6L_uc003hks.2_Missense_Mutation_p.K288R|CNOT6L_uc003hkt.1_Missense_Mutation_p.K131R|CNOT6L_uc011cce.1_3'UTR	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	288					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						CTTTTCTGTTTTGAAGAATAT	0.338													0	0	0	0.001984	0	6	31										C	78663304	T	C	78663304	3	2	27	1	0	0	0	0	1	0	0	0	3623	1841	64	5	824	5	CNOT6L	4	78663304	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	3810007	78663304	112490972	106	7359										
BMP3	651	broad.mit.edu	37	chr4	81967324	81967324	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgccaatgatgccgccatttCtgagccagaaagtgtggtat	11	9	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:81967324C>T	uc003hmg.3	+	2	1069	c.749C>T	c.(748-750)TCT>TTT	p.S250F		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	250					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						GCCGCCATTTCTGAGCCAGAA	0.473													0	0	0	0.004007	0	15	114										T	81967324	C	T	81967324	3	4	27	1	0	0	0	0	1	0	0	0	1461	913	32	1	755	1	BMP3	4	81967324	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3304020	81967324	109186952	107	7360										
COPS4	51138	broad.mit.edu	37	chr4	83996452	83996452	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cattttttttccccttagcaCgagaagccctgccaacgtgg	8	13	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:83996452C>T	uc003hoa.2	+	10	1229	c.1090C>T	c.(1090-1092)CGA>TGA	p.R364*	COPS4_uc003hob.2_Missense_Mutation_p.T413M|COPS4_uc010ijw.2_Nonsense_Mutation_p.R396*|COPS4_uc010ijx.2_Silent_p.H335H	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	364					cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				CCCCTTAGCACGAGAAGCCCT	0.363													0	0	0	0.000602	0	5	54										T	83996452	C	T	83996452	4	4	27	1	0	0	0	0	0	1	0	0	3735	528	19	2	1128	2	COPS4	4	83996452	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2029128	83996452	107157824	108	7361										
ZNF330	27309	broad.mit.edu	37	chr4	142147922	142147922	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaatgtttttcttcattaggGaaaacaaagtgcatgatgaa	8	4	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:142147922G>A	uc003iiq.3	+	5	433	c.213G>A	c.(211-213)GGG>GGA	p.G71G	ZNF330_uc011chl.1_Silent_p.G11G	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	71	C4-type 2 (Potential).					chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					CTTCATTAGGGAAAACAAAGT	0.393													0	0	0	0.003954	0	24	109										A	142147922	G	A	142147922	2	1	27	1	0	0	0	0	0	0	0	1	17845	1188	41	1		1	ZNF330	4	142147922	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	58151470	142147922	49006354	109	7362										
PLRG1	5356	broad.mit.edu	37	chr4	155458505	155458505	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgttagtaatcgactttcaGactgatcaaaagcacaagca	7	9	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:155458505G>C	uc003iny.2	-	14	1481	c.1418C>G	c.(1417-1419)TCT>TGT	p.S473C	PLRG1_uc003inz.2_Missense_Mutation_p.S464C	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	473	WD 7.					catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				TCGACTTTCAGACTGATCAAA	0.408													0	0	0	0.003163	0	15	41										C	155458505	G	C	155458505	3	2	27	1	0	0	0	0	1	0	0	0	12106	942	33	1	134	1	PLRG1	4	155458505	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	13310583	155458505	35695771	110	7363										
FGA	2243	broad.mit.edu	37	chr4	155507881	155507881	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctggctcttaaaatttccggGaaccaagtctggaactggtt	10	9	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:155507881G>C	uc003iod.1	-	5	758	c.700C>G	c.(700-702)CCC>GCC	p.P234A	FGA_uc003ioe.1_Missense_Mutation_p.P234A|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	234	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AAATTTCCGGGAACCAAGTCT	0.458													0	0	0	0.004672	0	3	137										C	155507881	G	C	155507881	3	2	27	1	0	0	0	0	1	0	0	0	5830	1174	41	1	1952	1	FGA	4	155507881	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	49376	155507881	35646395	111	7364										
HMGB2	3148	broad.mit.edu	37	chr4	174254744	174254744	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcttcccggcaggtctgcacGaagaaggcgtacgaggacat	13	11	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:174254744G>A	uc011ckc.1	-	1	177	c.57C>T	c.(55-57)TTC>TTT	p.F19F	HMGB2_uc003ita.3_Silent_p.F19F|HMGB2_uc003itb.2_Silent_p.F19F|HMGB2_uc003itc.2_Silent_p.F19F	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	19	HMG box 1.				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AGGTCTGCACGAAGAAGGCGT	0.582													0	0	0	0.001984	0	7	70										A	174254744	G	A	174254744	2	1	27	1	0	0	0	0	0	0	0	1	7226	1049	37	1		1	HMGB2	4	174254744	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	18746863	174254744	16899532	112	7365										
ODZ3	55714	broad.mit.edu	37	chr4	183675804	183675804	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatgagaagaaaattaaccgGataaggcaggtcacaacaga	11	6	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:183675804G>C	uc003ivd.1	+	21	4321	c.4284G>C	c.(4282-4284)CGG>CGC	p.R1428R	ODZ3_uc003ive.1_Silent_p.R841R	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1428	Extracellular (Potential).|NHL 4.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AAATTAACCGGATAAGGCAGG	0.478													0	0	0	0.004672	0	3	36										C	183675804	G	C	183675804	2	2	27	1	0	0	0	0	0	0	0	1	10836	1161	41	1		1	ODZ3	4	183675804	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9421060	183675804	7478472	113	7366										
SNX25	83891	broad.mit.edu	37	chr4	186278863	186278863	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaacattaattgccctcgttCaggtcacttttggaagaacc	8	10	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr4:186278863C>T	uc003ixh.2	+	16	2320	c.2131C>T	c.(2131-2133)CAG>TAG	p.Q711*	SNX25_uc010ish.2_Nonsense_Mutation_p.Q427*|SNX25_uc003ixi.2_Nonsense_Mutation_p.Q215*	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	711					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TGCCCTCGTTCAGGTCACTTT	0.368													0	0	0	0.006214	0	10	104										T	186278863	C	T	186278863	4	4	27	1	0	0	0	0	0	1	0	0	14896	827	29	1	2189	1	SNX25	4	186278863	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2603059	186278863	4875413	114	7367										
DNAH5	1767	broad.mit.edu	37	chr5	13865914	13865914	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtagaagatttagttgcttCtttatttcaagaagctgagg	10	4	2	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:13865914C>G	uc003jfd.2	-	27	4260	c.4218G>C	c.(4216-4218)AAG>AAC	p.K1406N		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1406	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTAGTTGCTTCTTTATTTCAA	0.343									Kartagener_syndrome				0	0	0	0.008871	0	19	113										G	13865914	C	G	13865914	3	3	27	1	0	0	0	0	1	0	0	0	4604	912	32	1	9868	1	DNAH5	5	13865914	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		13865914	167049346	115	7368										
NIPBL	25836	broad.mit.edu	37	chr5	37045560	37045560	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	attaggtgccatttcaaaatTaaaaagtcaacaccaagagg	7	7	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:37045560T>A	uc003jkl.3	+	37	6858	c.6359T>A	c.(6358-6360)TTA>TAA	p.L2120*	NIPBL_uc003jkk.3_Nonsense_Mutation_p.L2120*	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2120					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ATTTCAAAATTAAAAAGTCAA	0.303													0	0	0	0.01441	0	51	151										A	37045560	T	A	37045560	4	1	27	1	0	0	0	0	0	1	0	0	10428	1764	61	5	6501	5	NIPBL	5	37045560	Nonsense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	23179646	37045560	143869700	116	7369										
WDR70	55100	broad.mit.edu	37	chr5	37703084	37703084	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttcagtccagatgataagctCatagtcactggtacatctat	7	9	4	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:37703084C>G	uc003jkv.2	+	13	1369	c.1311C>G	c.(1309-1311)CTC>CTG	p.L437L		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	437	WD 6.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATGATAAGCTCATAGTCACTG	0.413													0	0	0	0.00308	0	8	130										G	37703084	C	G	37703084	2	3	27	1	0	0	0	0	0	0	0	1	17318	813	29	1		1	WDR70	5	37703084	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	657524	37703084	143212176	117	7370										
LIFR	3977	broad.mit.edu	37	chr5	38484884	38484884	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcagaactattaccattctcGtttccgatagcaaaggatac	7	10	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:38484884G>A	uc010ive.1	-	18	2916	c.2584C>T	c.(2584-2586)CGA>TGA	p.R862*	LIFR_uc003jli.2_Nonsense_Mutation_p.R862*	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	862	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					TACCATTCTCGTTTCCGATAG	0.363			T	PLAG1	salivary adenoma								0	0	0	0.009096	0	4	29										A	38484884	G	A	38484884	4	1	27	1	0	0	0	0	0	1	0	0	8780	1153	40	2	721	2	LIFR	5	38484884	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	781800	38484884	142430376	118	7371										
ZNF131	7690	broad.mit.edu	37	chr5	43161885	43161885	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgatatcttcgagagagcgcAtggaaacagcacctaaattg	10	9	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:43161885A>G	uc011cpw.1	+	5	942	c.906A>G	c.(904-906)GCA>GCG	p.A302A	ZNF131_uc010ivl.1_Silent_p.A268A|ZNF131_uc003jnj.3_Silent_p.A23A|ZNF131_uc003jnk.2_Silent_p.A268A|ZNF131_uc003jnn.3_Silent_p.A23A|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	302	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGAGAGCGCATGGAAACAGC	0.373													0	0	0	0.010504	0	21	65										G	43161885	A	G	43161885	2	3	27	1	0	0	0	0	0	0	0	1	17718	204	8	5		5	ZNF131	5	43161885	Silent	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	4677001	43161885	137753375	119	7372										
FST	10468	broad.mit.edu	37	chr5	52778823	52778823	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggctgagcacctcgtggaccGaggaggacgtgaatgacaac	15	10	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:52778823G>C	uc003jpd.2	+	2	226	c.199G>C	c.(199-201)GAG>CAG	p.E67Q	FST_uc003jpc.2_Missense_Mutation_p.E67Q	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	67	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CTCGTGGACCGAGGAGGACGT	0.587											OREG0016608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	28										C	52778823	G	C	52778823	3	2	27	1	0	0	0	0	1	0	0	0	6076	1059	37	1	205	1	FST	5	52778823	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9616938	52778823	128136437	120	7373										
DHX29	54505	broad.mit.edu	37	chr5	54579357	54579357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaagaggtttctaacaggttCcaaatcttccacatttgctg	7	9	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:54579357C>T	uc003jpx.2	-	11	1759	c.1639G>A	c.(1639-1641)GAA>AAA	p.E547K	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	547							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				CTAACAGGTTCCAAATCTTCC	0.398													0	0	0	0.003163	0	16	224										T	54579357	C	T	54579357	3	4	27	1	0	0	0	0	1	0	0	0	4503	864	30	1	2538	1	DHX29	5	54579357	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1800534	54579357	126335903	121	7374										
DHX29	54505	broad.mit.edu	37	chr5	54579455	54579455	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgggatcttcagagttttctCtcttattttcagaatgctgt	8	8	5	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:54579455C>G	uc003jpx.2	-	11	1661	c.1541G>C	c.(1540-1542)AGA>ACA	p.R514T	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	514	Potential.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				AGAGTTTTCTCTCTTATTTTC	0.378													0	0	0	0.010504	0	21	165										G	54579455	C	G	54579455	3	3	27	1	0	0	0	0	1	0	0	0	4503	913	32	1	2636	1	DHX29	5	54579455	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	98	54579455	126335805	122	7375										
TAF9	6880	broad.mit.edu	37	chr5	68661350	68661350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgcggcactggattgccaatCgcacatcatctgcatcaaca	8	14	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:68661350C>T	uc003jwc.1	-	2	547	c.215G>A	c.(214-216)CGA>CAA	p.R72Q	TAF9_uc003jwa.2_Intron|TAF9_uc003jwb.2_Intron|TAF9_uc003jwd.1_Missense_Mutation_p.R72Q|TAF9_uc003jwe.1_Missense_Mutation_p.R72Q|TAF9_uc003jwf.1_Missense_Mutation_p.R72Q	NM_003187	NP_003178	Q16594	TAF9_HUMAN	TAF9 RNA polymerase II, TATA box binding	72					histone H3 acetylation|negative regulation of apoptosis|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cell growth|positive regulation of response to cytokine stimulus|positive regulation of transcription from RNA polymerase II promoter|response to interleukin-1|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	MLL1 complex|PCAF complex|pre-snoRNP complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	activating transcription factor binding|C2H2 zinc finger domain binding|p53 binding|transcription coactivator activity|transcription regulatory region DNA binding				0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.1e-56)|Epithelial(20;9.54e-53)|all cancers(19;2.2e-48)|Lung(70;0.0176)		GATTGCCAATCGCACATCATC	0.418													0	0	0	0.00245	0	14	144										T	68661350	C	T	68661350	3	4	27	1	0	0	0	0	1	0	0	0	15532	884	31	1	993	1	TAF9	5	68661350	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	14081895	68661350	112253910	123	7376										
POLK	51426	broad.mit.edu	37	chr5	74869692	74869692	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aataccgagctgtgagtaaaGaggtaagttaatgtctcacc	10	7	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:74869692G>C	uc003kdw.2	+	5	634	c.538G>C	c.(538-540)GAG>CAG	p.E180Q	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kea.2_Missense_Mutation_p.E180Q|POLK_uc003keb.2_Missense_Mutation_p.E180Q|POLK_uc010izq.2_Missense_Mutation_p.E180Q|POLK_uc003kec.2_Missense_Mutation_p.E90Q|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.E90Q|POLK_uc003kee.2_Missense_Mutation_p.E180Q|POLK_uc003kef.2_Missense_Mutation_p.E90Q	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	180	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TGTGAGTAAAGAGGTAAGTTA	0.458								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.009096	0	4	69										C	74869692	G	C	74869692	3	2	27	1	0	0	0	0	1	0	0	0	12204	943	33	1	552	1	POLK	5	74869692	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	6208342	74869692	106045568	124	7377										
POC5	134359	broad.mit.edu	37	chr5	74970317	74970317	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gactgggtgtgagctgatctGgttccaagtgatctggaagc	15	7	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:74970317G>C	uc003keh.3	-	12	1868	c.1671C>G	c.(1669-1671)ACC>ACG	p.T557T	POC5_uc010izu.2_Silent_p.T381T|POC5_uc003keg.3_Silent_p.T532T	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	557					cell cycle	centriole				lung(1)	1						GAGCTGATCTGGTTCCAAGTG	0.433													0	0	0	0.00874	0	43	185										C	74970317	G	C	74970317	2	2	27	1	0	0	0	0	0	0	0	1	12177	1335	47	4		4	POC5	5	74970317	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	100625	74970317	105944943	125	7378										
FNIP1	96459	broad.mit.edu	37	chr5	131007915	131007915	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gggcagcctcacaagaaaatGaagcaggcacaatcttatct	9	10	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:131007915G>A	uc003kvs.1	-	14	2364	c.2222C>T	c.(2221-2223)TCA>TTA	p.S741L	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.S713L|FNIP1_uc010jdm.1_Missense_Mutation_p.S696L	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	741					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ACAAGAAAATGAAGCAGGCAC	0.453													0	0	0	0.008871	0	21	199										A	131007915	G	A	131007915	3	1	27	1	0	0	0	0	1	0	0	0	5975	1294	45	1	1298	1	FNIP1	5	131007915	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	56037598	131007915	49907345	126	7379										
SLC25A2	83884	broad.mit.edu	37	chr5	140683215	140683215	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccgagttttcggcgacgtagGccataagtgccgggccggtg	16	11	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:140683215G>A	uc003ljf.2	-	1	398	c.218C>T	c.(217-219)GCC>GTC	p.A73V		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	73	Helical; Name=2; (Potential).|Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	GGCGACGTAGGCCATAAGTGC	0.572													0	0	0	0.000602	0	5	78										A	140683215	G	A	140683215	3	1	27	1	0	0	0	0	1	0	0	0	14482	1203	42	2	691	2	SLC25A2	5	140683215	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9675300	140683215	40232045	127	7380										
GRXCR2	643226	broad.mit.edu	37	chr5	145239353	145239353	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcattgcaggcagggcacctCagggcccgataggactcctt	12	13	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:145239353C>T	uc003lns.1	-	3	690	c.690G>A	c.(688-690)CTG>CTA	p.L230L		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	230											0						CAGGGCACCTCAGGGCCCGAT	0.547													0	0	0	0.001984	0	7	66										T	145239353	C	T	145239353	2	4	27	1	0	0	0	0	0	0	0	1	6813	813	29	1		1	GRXCR2	5	145239353	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4556138	145239353	35675907	128	7381										
GPR151	134391	broad.mit.edu	37	chr5	145894520	145894520	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctcatgccaaaactgctctAcgtcaggaaggatgggaatc	10	10	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:145894520A>T	uc003lod.1	-	1	1157	c.1157T>A	c.(1156-1158)GTA>GAA	p.V386E		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	386	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAACTGCTCTACGTCAGGAAG	0.502													0	0	0	0.00278	0	23	49										T	145894520	A	T	145894520	3	4	27	1	0	0	0	0	1	0	0	0	6657	391	14	5	106	5	GPR151	5	145894520	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	655167	145894520	35020740	129	7382										
G3BP1	10146	broad.mit.edu	37	chr5	151169904	151169904	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	attttatggaaagaactcttCttatgtccatgggggattgg	11	5	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr5:151169904C>T	uc003lun.2	+	3	287	c.116C>T	c.(115-117)TCT>TTT	p.S39F	G3BP1_uc010jhy.1_Missense_Mutation_p.S39F|G3BP1_uc003lum.2_Missense_Mutation_p.S39F|G3BP1_uc011dcu.1_5'UTR|G3BP1_uc010jhz.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	39	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			AAGAACTCTTCTTATGTCCAT	0.368													0	0	0	0.000602	0	5	50										T	151169904	C	T	151169904	3	4	27	1	0	0	0	0	1	0	0	0	6141	913	32	1	122	1	G3BP1	5	151169904	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5275384	151169904	29745356	130	7383										
FOXQ1	94234	broad.mit.edu	37	chr6	1313343	1313343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgccatggccatccgcgactCggcgggcgggcgcttgacgc	16	16	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:1313343C>T	uc003mtl.3	+	1	669	c.404C>T	c.(403-405)TCG>TTG	p.S135L		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	135	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ATCCGCGACTCGGCGGGCGGG	0.592													0	0	0	0.006122	0	8	9										T	1313343	C	T	1313343	3	4	27	1	0	0	0	0	1	0	0	0	6030	893	31	1	406	1	FOXQ1	6	1313343	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		1313343	169801724	131	7384										
NUP153	9972	broad.mit.edu	37	chr6	17669713	17669713	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcaatattcgccgagctgttGaactggtcacaccgtaagat	10	10	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:17669713G>T	uc003ncd.1	-	6	1117	c.917C>A	c.(916-918)TCA>TAA	p.S306*	NUP153_uc011dje.1_Nonsense_Mutation_p.S306*|NUP153_uc010jpl.1_Nonsense_Mutation_p.S306*	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	306					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			CCGAGCTGTTGAACTGGTCAC	0.373													1	0	0.00024832	0.009096	0.000258595	4	115										T	17669713	G	T	17669713	4	4	27	1	0	0	0	0	0	1	0	0	10755	1294	45	3	3578	3	NUP153	6	17669713	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	16356370	17669713	153445354	132	7385										
ALDH5A1	7915	broad.mit.edu	37	chr6	24503595	24503595	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tacggagacattatccacacCccggcaaaggacaggcgggc	12	13	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:24503595C>T	uc003neg.2	+	3	571	c.543C>T	c.(541-543)ACC>ACT	p.T181T	ALDH5A1_uc003nef.2_Silent_p.T181T	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	181					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TTATCCACACCCCGGCAAAGG	0.572													0	0	0	0.010729	0	3	35										T	24503595	C	T	24503595	2	4	27	1	0	0	0	0	0	0	0	1	502	610	22	2		2	ALDH5A1	6	24503595	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6833882	24503595	146611472	133	7386										
BTN2A1	11120	broad.mit.edu	37	chr6	26468591	26468591	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatgtctccttctacaacatGagggacagatcgcacatcta	8	11	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:26468591G>A	uc003nib.1	+	8	1610	c.1398G>A	c.(1396-1398)ATG>ATA	p.M466I	BTN2A1_uc003nic.1_3'UTR|BTN2A1_uc003nid.1_Missense_Mutation_p.M314I|BTN2A1_uc011dko.1_Missense_Mutation_p.M405I|BTN2A1_uc010jqk.1_Missense_Mutation_p.M226I	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	466	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						TCTACAACATGAGGGACAGAT	0.552													0	0	0	0.001168	0	5	163										A	26468591	G	A	26468591	3	1	27	1	0	0	0	0	1	0	0	0	1560	1290	45	1	1451	1	BTN2A1	6	26468591	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1964996	26468591	144646476	134	7387										
OR2B6	26212	broad.mit.edu	37	chr6	27925387	27925387	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtcatgtcctttgataggttTgtagctatttgtcggcctct	10	8	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:27925387T>A	uc011dkx.1	+	1	369	c.369T>A	c.(367-369)TTT>TTA	p.F123L		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTGATAGGTTTGTAGCTATTT	0.473													0	0	0	0.00623	0	40	155										A	27925387	T	A	27925387	3	1	27	1	0	0	0	0	1	0	0	0	10991	1809	63	5	371	5	OR2B6	6	27925387	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	1456796	27925387	143189680	135	7388										
SYNGAP1	8831	broad.mit.edu	37	chr6	33391253	33391253	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgtgtgtctctgtcctccaGatgtacggggaccctctatg	11	12	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:33391253G>C	uc011dri.1	+	2	263	c.68_splice	c.e2-1	p.D23_splice	SYNGAP1_uc003oeo.1_Splice_Site_p.D8_splice|SYNGAP1_uc010juy.2_Splice_Site_p.D8_splice	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CTGTCCTCCAGATGTACGGGG	0.522													0	0	0	0.01441	0	63	185										C	33391253	G	C	33391253	5	2	27	1	0	0	0	0	0	0	1	0	15444	956	33	1	73	1	SYNGAP1	6	33391253	Splice_Site	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5465866	33391253	137723814	136	7389										
C6orf142	90523	broad.mit.edu	37	chr6	54025594	54025594	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgttgggttctgacacagtCaaagtatgtatgtatttaat	9	4	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:54025594C>G	uc003pcg.3	+	7	1004	c.891C>G	c.(889-891)GTC>GTG	p.V297V	C6orf142_uc003pcf.2_Silent_p.V821V|C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Silent_p.V832V	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	297						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CTGACACAGTCAAAGTATGTA	0.179													0	0	0	0.004482	0	7	85										G	54025594	C	G	54025594	2	3	27	1	0	0	0	0	0	0	0	1	2333	813	29	1		1	C6orf142	6	54025594	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	20634341	54025594	117089473	137	7390										
COL19A1	1310	broad.mit.edu	37	chr6	70639365	70639365	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aggtggtggaatttatgtttCaagccacagagggagatgtg	15	4	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:70639365C>G	uc003pfc.1	+	6	556	c.439C>G	c.(439-441)CAA>GAA	p.Q147E	COL19A1_uc010kam.1_Missense_Mutation_p.Q43E	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	147	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ATTTATGTTTCAAGCCACAGA	0.338													0	0	0	0.001984	0	4	66										G	70639365	C	G	70639365	3	3	27	1	0	0	0	0	1	0	0	0	3676	827	29	1	457	1	COL19A1	6	70639365	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	16613771	70639365	100475702	138	7391										
MYO6	4646	broad.mit.edu	37	chr6	76576333	76576333	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgcgggggcagtgtgctatGaaacagtgagtataactttt	13	5	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:76576333G>A	uc003pih.1	+	17	2044	c.1765G>A	c.(1765-1767)GAA>AAA	p.E589K	MYO6_uc003pig.1_Missense_Mutation_p.E589K|MYO6_uc003pii.1_Missense_Mutation_p.E589K	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	589	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AGTGTGCTATGAAACAGTGAG	0.299													0	0	0	0.00308	0	8	62										A	76576333	G	A	76576333	3	1	27	1	0	0	0	0	1	0	0	0	10081	1291	45	1	1827	1	MYO6	6	76576333	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5936968	76576333	94538734	139	7392										
GPR63	81491	broad.mit.edu	37	chr6	97247160	97247160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	taccctacagaagaatttccCaaaaatccatcgggtagtaa	6	10	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:97247160C>T	uc010kcl.2	-	3	926	c.448G>A	c.(448-450)GGG>AGG	p.G150R	GPR63_uc003pou.2_Missense_Mutation_p.G150R	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	150	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AAGAATTTCCCAAAAATCCAT	0.418													0	0	0	0.014323	0	22	56										T	97247160	C	T	97247160	3	4	27	1	0	0	0	0	1	0	0	0	6704	594	21	2	815	2	GPR63	6	97247160	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	20670827	97247160	73867907	140	7393										
C6orf204	387119	broad.mit.edu	37	chr6	118791768	118791768	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagctcttccatcatcttttGagtggtcagtttctctttag	7	10	5	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:118791768G>C	uc003pxz.1	-	11	2542	c.1954C>G	c.(1954-1956)CAA>GAA	p.Q652E		NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	652	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		ATCATCTTTTGAGTGGTCAGT	0.308													0	0	0	0.001984	0	5	118										C	118791768	G	C	118791768	3	2	27	1	0	0	0	0	1	0	0	0	2353	1299	45	1	475	1	C6orf204	6	118791768	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	21544608	118791768	52323299	141	7394										
VNN2	8875	broad.mit.edu	37	chr6	133070857	133070857	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaattttccaggtgacagatGaatttcggtaagtagcactt	9	6	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:133070857G>A	uc003qdt.2	-	6	1359	c.1348C>T	c.(1348-1350)CAT>TAT	p.H450Y	VNN2_uc003qds.2_Missense_Mutation_p.H159Y|VNN2_uc010kgb.2_Missense_Mutation_p.H229Y|VNN2_uc003qdv.2_Missense_Mutation_p.H397Y	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	450					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GGTGACAGATGAATTTCGGTA	0.378													0	0	0	0.009096	0	4	60										A	133070857	G	A	133070857	3	1	27	1	0	0	0	0	1	0	0	0	17180	1290	45	1	222	1	VNN2	6	133070857	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	14279089	133070857	38044210	142	7395										
BCLAF1	9774	broad.mit.edu	37	chr6	136589449	136589449	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgctgaagaggatgaagatcGagaatgatcttgctctcttt	11	6	2	6	rs147719127		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:136589449G>C	uc003qgx.1	-	10	2501	c.2248C>G	c.(2248-2250)CGA>GGA	p.R750G	BCLAF1_uc011edb.1_Missense_Mutation_p.R78G|BCLAF1_uc003qgw.1_Missense_Mutation_p.R577G|BCLAF1_uc003qgy.1_Missense_Mutation_p.R748G|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R748G	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	750	Poly-Ser.				induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GATGAAGATCGAGAATGATCT	0.338													0	0	0	0.000602	0	5	111										C	136589449	G	C	136589449	3	2	27	1	0	0	0	0	1	0	0	0	1383	1066	37	1	530	1	BCLAF1	6	136589449	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3518592	136589449	34525618	143	7396										
BCLAF1	9774	broad.mit.edu	37	chr6	136599168	136599168	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gactattctgagaaggactgTatcgactagatccatttcca	8	9	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:136599168T>C	uc003qgx.1	-	4	1104	c.851A>G	c.(850-852)TAC>TGC	p.Y284C	BCLAF1_uc003qgw.1_Missense_Mutation_p.Y284C|BCLAF1_uc003qgy.1_Missense_Mutation_p.Y282C|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.Y282C	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	284					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGAAGGACTGTATCGACTAGA	0.453													0	0	0	0.004482	0	9	86										C	136599168	T	C	136599168	3	2	27	1	0	0	0	0	1	0	0	0	1383	1638	57	5	1951	5	BCLAF1	6	136599168	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	9719	136599168	34515899	144	7397										
VTA1	51534	broad.mit.edu	37	chr6	142487389	142487389	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tttatacgcaatgcagactgGaatgaagatcgatagtaaaa	9	5	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:142487389G>C	uc003qiw.2	+	2	152	c.137G>C	c.(136-138)GGA>GCA	p.G46A	VTA1_uc011edt.1_RNA|VTA1_uc011edu.1_Intron	NM_016485	NP_057569	Q9NP79	VTA1_HUMAN	Vps20-associated 1 homolog	46	Interaction with CHMP5.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	cytosol|endosome membrane	protein binding				0	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;1.34e-05)|GBM - Glioblastoma multiforme(68;0.00182)		ATGCAGACTGGAATGAAGATC	0.289													0	0	0	0.004672	0	3	100										C	142487389	G	C	142487389	3	2	27	1	0	0	0	0	1	0	0	0	17230	1174	41	1	143	1	VTA1	6	142487389	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5888221	142487389	28627678	145	7398										
LATS1	9113	broad.mit.edu	37	chr6	150005065	150005065	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atccccctgtttgtaaagcaGaagggctttgtccattagct	9	10	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:150005065G>A	uc003qmu.1	-	4	1708	c.1160C>T	c.(1159-1161)TCT>TTT	p.S387F	LATS1_uc010kif.1_Missense_Mutation_p.S282F|LATS1_uc003qmv.1_Missense_Mutation_p.S387F|LATS1_uc003qmw.2_Missense_Mutation_p.S387F|LATS1_uc010kig.1_Missense_Mutation_p.S282F	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	387					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TTGTAAAGCAGAAGGGCTTTG	0.453													0	0	0	0.007413	0	19	129										A	150005065	G	A	150005065	3	1	27	1	0	0	0	0	1	0	0	0	8646	942	33	1	2252	1	LATS1	6	150005065	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	7517676	150005065	21110002	146	7399										
LATS1	9113	broad.mit.edu	37	chr6	150005361	150005361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccccaggtgggacaggagaGattcgggagattacgtattc	15	8	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr6:150005361G>C	uc003qmu.1	-	4	1412	c.864C>G	c.(862-864)ATC>ATG	p.I288M	LATS1_uc010kif.1_Missense_Mutation_p.I183M|LATS1_uc003qmv.1_Missense_Mutation_p.I288M|LATS1_uc003qmw.2_Missense_Mutation_p.I288M|LATS1_uc010kig.1_Missense_Mutation_p.I183M	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	288					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		GGACAGGAGAGATTCGGGAGA	0.517													0	0	0	0.004007	0	17	159										C	150005361	G	C	150005361	3	2	27	1	0	0	0	0	1	0	0	0	8646	932	33	1	2548	1	LATS1	6	150005361	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	296	150005361	21109706	147	7400										
DNAH11	8701	broad.mit.edu	37	chr7	21775305	21775305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctcgtcttagatatttcatGgagttgttgcttgagaaagg	12	5	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:21775305G>A	uc003svc.2	+	47	7540	c.7509G>A	c.(7507-7509)ATG>ATA	p.M2503I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2503	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GATATTTCATGGAGTTGTTGC	0.343									Kartagener_syndrome				0	0	0	0.000602	0	5	36										A	21775305	G	A	21775305	3	1	27	1	0	0	0	0	1	0	0	0	4599	1348	47	2	7692	2	DNAH11	7	21775305	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08		21775305	137363358	148	7401										
STK31	56164	broad.mit.edu	37	chr7	23810677	23810677	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aatacatatagtcaagtactGcaaaagattcattcagagga	7	6	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:23810677G>T	uc003sws.3	+	14	1834	c.1767G>T	c.(1765-1767)CTG>CTT	p.L589L	STK31_uc003swt.3_Silent_p.L566L|STK31_uc011jze.1_Silent_p.L589L|STK31_uc010kuq.2_Silent_p.L566L	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	589							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						GTCAAGTACTGCAAAAGATTC	0.338													1	0	2.3441e-25	0.01441	2.55874e-25	62	140										T	23810677	G	T	23810677	2	4	27	1	0	0	0	0	0	0	0	1	15295	1306	46	4		4	STK31	7	23810677	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2035372	23810677	135327986	149	7402										
HOXA1	3198	broad.mit.edu	37	chr7	27135406	27135406	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccgccgcaactgttggcgctGaccgcgcacgactggaaagt	13	14	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:27135406G>A	uc003sye.2	-	1	220	c.126C>T	c.(124-126)GTC>GTT	p.V42V	HOXA1_uc003syd.2_Silent_p.V42V|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	42						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						TGTTGGCGCTGACCGCGCACG	0.522											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.010729	0	10	104										A	27135406	G	A	27135406	2	1	27	1	0	0	0	0	0	0	0	1	7288	1277	45	1		1	HOXA1	7	27135406	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3324729	27135406	132003257	150	7403										
ZNF735	730291	broad.mit.edu	37	chr7	63667599	63667599	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttatggctaaaagaccgggaCcccctggaagccgagaaatg	12	10	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:63667599C>T	uc011kdn.1	+	1	19	c.19C>T	c.(19-21)CCC>TCC	p.P7S		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGACCGGGACCCCCTGGAAG	0.562													0	0	0	0.001984	0	4	50										T	63667599	C	T	63667599	3	4	27	1	0	0	0	0	1	0	0	0	18121	507	18	2	21	2	ZNF735	7	63667599	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	36532193	63667599	95471064	151	7404										
PPP1R9A	55607	broad.mit.edu	37	chr7	94915637	94915637	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttagcactgtcatcagatgaGgtaattccatggcactatga	9	8	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:94915637G>T	uc003unp.2	+	13	3159	c.2877G>T	c.(2875-2877)GAG>GAT	p.E959D	PPP1R9A_uc010lfj.2_Missense_Mutation_p.E1243D|PPP1R9A_uc011kif.1_Missense_Mutation_p.E1165D|PPP1R9A_uc003unq.2_Missense_Mutation_p.E1183D|PPP1R9A_uc011kig.1_Missense_Mutation_p.E959D|PPP1R9A_uc003unr.2_Missense_Mutation_p.E256D	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	959	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CATCAGATGAGGTAATTCCAT	0.458										HNSCC(28;0.073)			1	0	0.00024832	0.009096	0.000258595	4	85										T	94915637	G	T	94915637	3	4	27	1	0	0	0	0	1	0	0	0	12378	1014	35	4	3795	4	PPP1R9A	7	94915637	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	31248038	94915637	64223026	152	7405										
SRRT	51593	broad.mit.edu	37	chr7	100482607	100482607	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgacgagggcagcgtgtcaGagtctgagtcggagtcagag	17	7	3	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:100482607G>A	uc003uwy.2	+	10	1373	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	SRRT_uc010lhl.1_Missense_Mutation_p.E369K|SRRT_uc003uxa.2_Missense_Mutation_p.E369K|SRRT_uc003uwz.2_Missense_Mutation_p.E369K	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	369	Glu-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						CAGCGTGTCAGAGTCTGAGTC	0.577													0	0	0	0.001168	0	6	274										A	100482607	G	A	100482607	3	1	27	1	0	0	0	0	1	0	0	0	15171	943	33	1	1135	1	SRRT	7	100482607	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5566970	100482607	58656056	153	7406										
TRIM56	81844	broad.mit.edu	37	chr7	100731650	100731650	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctgcctgctcccacagctgGagctccatcctgggctcctg	10	18	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:100731650G>C	uc003uxq.2	+	3	1288	c.1057G>C	c.(1057-1059)GAG>CAG	p.E353Q	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	353					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					CCCACAGCTGGAGCTCCATCC	0.662													0	0	0	0.009096	0	4	8										C	100731650	G	C	100731650	3	2	27	1	0	0	0	0	1	0	0	0	16527	1175	41	1	1059	1	TRIM56	7	100731650	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	249043	100731650	58407013	154	7407										
SND1	27044	broad.mit.edu	37	chr7	127341354	127341354	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cccaaggcactttgtggactCacaccaccagaagcctgtta	8	14	1	1	rs34667910		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:127341354C>G	uc003vmi.2	+	5	792	c.566C>G	c.(565-567)TCA>TGA	p.S189*		NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	189					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						TTTGTGGACTCACACCACCAG	0.483													0	0	0	0.001168	0	6	73										G	127341354	C	G	127341354	4	3	27	1	0	0	0	0	0	1	0	0	14844	838	29	1	584	1	SND1	7	127341354	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	26609704	127341354	31797309	155	7408										
TSGA14	95681	broad.mit.edu	37	chr7	130067815	130067815	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccagtgtccagtcttgatttGatatgctggtatcttgggtt	11	7	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:130067815G>C	uc003vpz.2	-	2	125	c.78C>G	c.(76-78)ATC>ATG	p.I26M	TSGA14_uc010lmf.2_Translation_Start_Site|TSGA14_uc003vqa.2_Missense_Mutation_p.I26M|TSGA14_uc011kpg.1_Missense_Mutation_p.I26M|TSGA14_uc003vqb.1_RNA	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	26					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					GTCTTGATTTGATATGCTGGT	0.313													0	0	0	0.012213	0	28	56										C	130067815	G	C	130067815	3	2	27	1	0	0	0	0	1	0	0	0	16617	1280	45	1	1083	1	TSGA14	7	130067815	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2726461	130067815	29070848	156	7409										
TRPV5	56302	broad.mit.edu	37	chr7	142605898	142605898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agatggatgctcctggtcatCctccttgtctgagttcttga	10	10	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:142605898C>T	uc003wby.1	-	15	2236	c.1972G>A	c.(1972-1974)GAT>AAT	p.D658N		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	658	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					TCCTGGTCATCCTCCTTGTCT	0.532													0	0	0	0.001168	0	6	66										T	142605898	C	T	142605898	3	4	27	1	0	0	0	0	1	0	0	0	16596	855	30	1	221	1	TRPV5	7	142605898	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	12538083	142605898	16532765	157	7410										
TAS2R60	338398	broad.mit.edu	37	chr7	143141483	143141483	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctgaagagtcgtcgttcctCaaggtgtgggacaccttgag	14	9	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:143141483C>T	uc011ktg.1	+	1	938	c.938C>T	c.(937-939)TCA>TTA	p.S313L	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	313	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					CGTCGTTCCTCAAGGTGTGGG	0.502													0	0	0	0.010729	0	10	118										T	143141483	C	T	143141483	3	4	27	1	0	0	0	0	1	0	0	0	15582	838	29	1	940	1	TAS2R60	7	143141483	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	535585	143141483	15997180	158	7411										
OR6B1	135946	broad.mit.edu	37	chr7	143701967	143701967	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	catttattgcctaagaaaccGagaggtcaaggaagctctga	10	8	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:143701967G>A	uc003wdt.1	+	1	878	c.878G>A	c.(877-879)CGA>CAA	p.R293Q		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					CTAAGAAACCGAGAGGTCAAG	0.433													0	0	0	0.010729	0	12	73										A	143701967	G	A	143701967	3	1	27	1	0	0	0	0	1	0	0	0	11187	1058	37	1	880	1	OR6B1	7	143701967	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	560484	143701967	15436696	159	7412										
CNTNAP2	26047	broad.mit.edu	37	chr7	146536942	146536942	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtgacccaataccggatgctCtacagcgacacagggagaaa	11	11	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:146536942C>G	uc003weu.1	+	3	864	c.348C>G	c.(346-348)CTC>CTG	p.L116L		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	116	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACCGGATGCTCTACAGCGACA	0.468										HNSCC(39;0.1)			0	0	0	0.000602	0	5	38										G	146536942	C	G	146536942	2	3	27	1	0	0	0	0	0	0	0	1	3647	900	32	1		1	CNTNAP2	7	146536942	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2834975	146536942	12601721	160	7413										
SSPO	23145	broad.mit.edu	37	chr7	149522395	149522395	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaggcccaagacactgtattCaccctggactgtgccaacca	9	14	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:149522395C>T	uc010lpk.2	+	101	14022	c.14022C>T	c.(14020-14022)TTC>TTT	p.F4674F	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_RNA|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4674	TIL 6.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACACTGTATTCACCCTGGACT	0.637													0	0	0	0.008871	0	21	68										T	149522395	C	T	149522395	2	4	27	1	0	0	0	0	0	0	0	1	15188	826	29	1		1	SSPO	7	149522395	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2985453	149522395	9616268	161	7414										
GIMAP5	55340	broad.mit.edu	37	chr7	150439547	150439547	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cggggactgctacctgctctCtgccccggggccccacgtcc	12	19	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:150439547C>G	uc003whr.1	+	3	672	c.320C>G	c.(319-321)TCT>TGT	p.S107C	GIMAP5_uc010lpu.2_5'UTR	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	107	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TACCTGCTCTCTGCCCCGGGG	0.582													0	0	0	0.008291	0	11	88										G	150439547	C	G	150439547	3	3	27	1	0	0	0	0	1	0	0	0	6382	913	32	1	326	1	GIMAP5	7	150439547	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	917152	150439547	8699116	162	7415										
GIMAP5	55340	broad.mit.edu	37	chr7	150439620	150439620	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctcaggacacagtggccatCaggaaggtgaaagaggtctt	14	8	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:150439620C>G	uc003whr.1	+	3	745	c.393C>G	c.(391-393)ATC>ATG	p.I131M	GIMAP5_uc010lpu.2_Translation_Start_Site	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	131	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGTGGCCATCAGGAAGGTGA	0.592													0	0	0	0.004482	0	9	120										G	150439620	C	G	150439620	3	3	27	1	0	0	0	0	1	0	0	0	6382	816	29	1	399	1	GIMAP5	7	150439620	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	73	150439620	8699043	163	7416										
AGAP3	116988	broad.mit.edu	37	chr7	150840866	150840866	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gggacgcccggggcctgactCcactggcatatgctcgccgg	15	15	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr7:150840866C>G	uc003wjg.1	+	18	2575	c.2572C>G	c.(2572-2574)CCA>GCA	p.P858A	AGAP3_uc003wje.1_Missense_Mutation_p.P527A|AGAP3_uc003wjj.1_Missense_Mutation_p.P357A|AGAP3_uc003wjk.1_Missense_Mutation_p.P276A	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	822	ANK 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						GGGCCTGACTCCACTGGCATA	0.617													0	0	0	0.001168	0	6	86										G	150840866	C	G	150840866	3	3	27	1	0	0	0	0	1	0	0	0	369	855	30	1	2709	1	AGAP3	7	150840866	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	401246	150840866	8297797	164	7417										
C8orf42	157695	broad.mit.edu	37	chr8	442608	442608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agggtcagccgatatgtcttCaagagcaagttttggaggct	13	7	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:442608C>T	uc003wpd.2	-	3	923	c.349G>A	c.(349-351)GAA>AAA	p.E117K	C8orf42_uc011kwg.1_Missense_Mutation_p.E117K	NM_175075	NP_778250	Q86YL5	CH042_HUMAN	hypothetical protein LOC157695	117											0		Ovarian(12;0.0481)|Colorectal(14;0.0815)|Hepatocellular(245;0.0968)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;5.16e-14)|OV - Ovarian serous cystadenocarcinoma(5;7.35e-07)|BRCA - Breast invasive adenocarcinoma(11;4.17e-06)|COAD - Colon adenocarcinoma(149;0.0255)		GATATGTCTTCAAGAGCAAGT	0.493													0	0	0	0.001984	0	7	63										T	442608	C	T	442608	3	4	27	1	0	0	0	0	1	0	0	0	2428	835	29	1	212	1	C8orf42	8	442608	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		442608	145921414	165	7418										
C8orf42	157695	broad.mit.edu	37	chr8	442629	442629	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagagcaagttttggaggctCccaaccttcaatttcatctg	8	10	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:442629C>A	uc003wpd.2	-	3	902	c.328G>T	c.(328-330)GAG>TAG	p.E110*	C8orf42_uc011kwg.1_Nonsense_Mutation_p.E110*	NM_175075	NP_778250	Q86YL5	CH042_HUMAN	hypothetical protein LOC157695	110											0		Ovarian(12;0.0481)|Colorectal(14;0.0815)|Hepatocellular(245;0.0968)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;5.16e-14)|OV - Ovarian serous cystadenocarcinoma(5;7.35e-07)|BRCA - Breast invasive adenocarcinoma(11;4.17e-06)|COAD - Colon adenocarcinoma(149;0.0255)		TTTGGAGGCTCCCAACCTTCA	0.468													1	0	1.12685e-05	0.004482	1.18712e-05	9	73										A	442629	C	A	442629	4	1	27	1	0	0	0	0	0	1	0	0	2428	864	30	3	233	3	C8orf42	8	442629	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	21	442629	145921393	166	7419										
ESCO2	157570	broad.mit.edu	37	chr8	27645505	27645505	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atacaagtaaaaaaacaaaaGaccagctcatcatcgtgagt	6	8	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:27645505G>C	uc003xgg.2	+	6	1200	c.1117G>C	c.(1117-1119)GAC>CAC	p.D373H	ESCO2_uc010luy.1_RNA	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	373					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		AAAAACAAAAGACCAGCTCAT	0.289									SC_Phocomelia_syndrome				0	0	0	0.013537	0	13	107										C	27645505	G	C	27645505	3	2	27	1	0	0	0	0	1	0	0	0	5249	942	33	1	1135	1	ESCO2	8	27645505	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	27202876	27645505	118718517	167	7420										
PURG	29942	broad.mit.edu	37	chr8	30889612	30889612	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaggcatcacgaaactcaatCattccttgtgctgggaggac	10	10	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:30889612C>T	uc003xin.2	-	1	706	c.687G>A	c.(685-687)ATG>ATA	p.M229I	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.M229I	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	229	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		GAAACTCAATCATTCCTTGTG	0.488													0	0	0	0.003163	0	15	135										T	30889612	C	T	30889612	3	4	27	1	0	0	0	0	1	0	0	0	12829	826	29	1	469	1	PURG	8	30889612	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3244107	30889612	115474410	168	7421										
OPRK1	4986	broad.mit.edu	37	chr8	54147422	54147422	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tttgccttcaagggtgtgcgGaagtccaaagccttcacggg	13	10	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:54147422G>A	uc003xrh.1	-	2	882	c.507C>T	c.(505-507)TTC>TTT	p.F169F	OPRK1_uc003xri.1_Silent_p.F169F|OPRK1_uc010lyc.1_Silent_p.F80F	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	169	Cytoplasmic (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	AGGGTGTGCGGAAGTCCAAAG	0.512													0	0	0	0.000602	0	5	89										A	54147422	G	A	54147422	2	1	27	1	0	0	0	0	0	0	0	1	10885	1165	41	1		1	OPRK1	8	54147422	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	23257810	54147422	92216600	169	7422										
HNF4G	3174	broad.mit.edu	37	chr8	76471126	76471126	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctacatcaatgatcggcagtAtgactcccgggggaggtttg	13	9	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:76471126A>G	uc003yaq.2	+	9	1106	c.836A>G	c.(835-837)TAT>TGT	p.Y279C	HNF4G_uc003yar.2_Missense_Mutation_p.Y316C	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	279					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			GATCGGCAGTATGACTCCCGG	0.453													0	0	0	0.003271	0	35	89										G	76471126	A	G	76471126	3	3	27	1	0	0	0	0	1	0	0	0	7254	449	16	5	977	5	HNF4G	8	76471126	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	22323704	76471126	69892896	170	7423										
PKHD1L1	93035	broad.mit.edu	37	chr8	110535087	110535087	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agccaggacagccatttcctCagcagccttcggtaaaggca	10	13	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:110535087C>T	uc003yne.2	+	75	12402	c.12298C>T	c.(12298-12300)CAG>TAG	p.Q4100*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4100	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity	p.Q4100Q(1)		ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCCATTTCCTCAGCAGCCTTC	0.458										HNSCC(38;0.096)			0	0	0	0.001984	0	6	13										T	110535087	C	T	110535087	4	4	27	1	0	0	0	0	0	1	0	0	11972	827	29	1	12596	1	PKHD1L1	8	110535087	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	34063961	110535087	35828935	171	7424										
CSMD3	114788	broad.mit.edu	37	chr8	114448989	114448989	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccattttcttcatcaggatgAagtctaggcggccacattta	8	10	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:114448989A>T	uc003ynu.2	-	1	254	c.95T>A	c.(94-96)TTC>TAC	p.F32Y	CSMD3_uc011lhx.1_Missense_Mutation_p.F32Y|CSMD3_uc010mcx.1_Missense_Mutation_p.F32Y|CSMD3_uc003ynx.3_Missense_Mutation_p.F32Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	32	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATCAGGATGAAGTCTAGGCG	0.468										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.001168	0	5	178										T	114448989	A	T	114448989	3	4	27	1	0	0	0	0	1	0	0	0	3946	246	9	5	11374	5	CSMD3	8	114448989	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	3913902	114448989	31915033	172	7425										
WDR67	93594	broad.mit.edu	37	chr8	124095030	124095030	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aattccttgtggcattagctGattattctattaaatgtttt	6	5	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:124095030G>C	uc003ypp.1	+	3	403	c.313G>C	c.(313-315)GAT>CAT	p.D105H	WDR67_uc011lig.1_Missense_Mutation_p.D105H|WDR67_uc011lih.1_Intron|WDR67_uc003ypq.1_Intron|WDR67_uc003ypo.1_Missense_Mutation_p.D105H	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	105						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GGCATTAGCTGATTATTCTAT	0.348													0	0	0	0.009096	0	4	99										C	124095030	G	C	124095030	3	2	27	1	0	0	0	0	1	0	0	0	17315	1290	45	1	323	1	WDR67	8	124095030	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9646041	124095030	22268992	173	7426										
C8orf76	84933	broad.mit.edu	37	chr8	124250182	124250182	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaatactcctgcagtgctttCtggaaattatttgttaaata	7	6	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:124250182C>G	uc003yqc.1	-	3	245	c.214_splice	c.e3-1	p.K72_splice	C8orf76_uc003yqd.2_Splice_Site_p.K40_splice	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933								binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GCAGTGCTTTCTGGAAATTAT	0.378													0	0	0	0.004482	0	7	96										G	124250182	C	G	124250182	5	3	27	1	0	0	0	0	0	0	1	0	2437	927	32	1	945	1	C8orf76	8	124250182	Splice_Site	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	155152	124250182	22113840	174	7427										
LRRC6	23639	broad.mit.edu	37	chr8	133623581	133623581	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cacgtaagttggttgcacatCaacatcgattaaagaggtat	9	7	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:133623581C>T	uc003ytk.2	-	9	1077	c.1003G>A	c.(1003-1005)GAT>AAT	p.D335N	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	335	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GGTTGCACATCAACATCGATT	0.308													0	0	0	0.000602	0	4	60										T	133623581	C	T	133623581	3	4	27	1	0	0	0	0	1	0	0	0	9016	826	29	1	413	1	LRRC6	8	133623581	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9373399	133623581	12740441	175	7428										
KHDRBS3	10656	broad.mit.edu	37	chr8	136594141	136594141	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gggaaggggaggagttacagCccggccagttggagttgtag	19	6	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:136594141C>T	uc003yuv.2	+	6	1026	c.632C>T	c.(631-633)GCC>GTC	p.A211V	KHDRBS3_uc003yuw.2_Missense_Mutation_p.A211V|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	211					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			GGAGTTACAGCCCGGCCAGTT	0.502													0	0	0	0.010504	0	18	95										T	136594141	C	T	136594141	3	4	27	1	0	0	0	0	1	0	0	0	8148	739	26	2	654	2	KHDRBS3	8	136594141	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2970560	136594141	9769881	176	7429										
MGC70857	414919	broad.mit.edu	37	chr8	145753430	145753430	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgaagcaggtgatgaaattCttcattttggaatcatccag	9	6	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr8:145753430C>G	uc003zdp.1	-	2	341	c.183G>C	c.(181-183)AAG>AAC	p.K61N	LRRC24_uc003zdm.2_5'Flank|LRRC24_uc003zdn.2_5'Flank|MGC70857_uc003zdq.1_5'UTR|MGC70857_uc003zdr.1_RNA	NM_001001795	NP_001001795	Q6P1X6	CH082_HUMAN	hypothetical protein LOC414919	61											0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGATGAAATTCTTCATTTTGG	0.582													0	0	0	0.00245	0	12	61										G	145753430	C	G	145753430	3	3	27	1	0	0	0	0	1	0	0	0	9553	912	32	1	475	1	MGC70857	8	145753430	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9159289	145753430	610592	177	7430										
IL33	90865	broad.mit.edu	37	chr9	6252898	6252898	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttacagagtatcttgcttctCtaagcacatacaatgatcaa	5	9	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:6252898C>A	uc003zjt.2	+	5	433	c.376C>A	c.(376-378)CTA>ATA	p.L126I	IL33_uc011lmg.1_Intron|IL33_uc011lmh.1_Intron|IL33_uc003zju.1_Missense_Mutation_p.L126I	NM_033439	NP_254274	O95760	IL33_HUMAN	interleukin 33 precursor	126					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity				0		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		TCTTGCTTCTCTAAGCACATA	0.318													1	0	1.36161e-19	0.004289	1.48272e-19	38	86										A	6252898	C	A	6252898	3	1	27	1	0	0	0	0	1	0	0	0	7693	912	32	3	390	3	IL33	9	6252898	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		6252898	134960533	178	7431										
MPDZ	8777	broad.mit.edu	37	chr9	13113048	13113048	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcttaatccctgtatttcagAtgccactgtaaaggcaaaaa	6	9	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:13113048A>G	uc010mhy.2	-	40	5527	c.5476T>C	c.(5476-5478)TCT>CCT	p.S1826P	MPDZ_uc003zkx.3_Missense_Mutation_p.S91P|MPDZ_uc003zky.3_Missense_Mutation_p.S389P|MPDZ_uc010mib.2_Missense_Mutation_p.S560P|MPDZ_uc010mhx.2_Missense_Mutation_p.S677P|MPDZ_uc011lmm.1_Missense_Mutation_p.S714P|MPDZ_uc003zkz.3_Missense_Mutation_p.S548P|MPDZ_uc010mhz.2_Missense_Mutation_p.S1822P|MPDZ_uc011lmn.1_Missense_Mutation_p.S1793P|MPDZ_uc003zlb.3_Missense_Mutation_p.S1826P	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1855					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TGTATTTCAGATGCCACTGTA	0.323													0	0	0	0.004672	0	2	11										G	13113048	A	G	13113048	3	3	27	1	0	0	0	0	1	0	0	0	9722	333	12	5	673	5	MPDZ	9	13113048	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	6860150	13113048	128100383	179	7432										
OGN	4969	broad.mit.edu	37	chr9	95155527	95155527	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagcagacacgtgggcatttCtaaattgggaataaaatcat	9	7	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:95155527C>T	uc004asa.2	-	4	504	c.269_splice	c.e4-1	p.E90_splice	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|OGN_uc004asb.2_Splice_Site_p.E90_splice|OGN_uc011ltx.1_Splice_Site_p.E108_splice	NM_014057	NP_054776	P20774	MIME_HUMAN	osteoglycin preproprotein							extracellular space|proteinaceous extracellular matrix	growth factor activity				0						GTGGGCATTTCTAAATTGGGA	0.333													0	0	0	0.001984	0	6	43										T	95155527	C	T	95155527	5	4	27	1	0	0	0	0	0	0	1	0	10846	927	32	1	644	1	OGN	9	95155527	Splice_Site	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	82042479	95155527	46057904	180	7433										
PHF2	5253	broad.mit.edu	37	chr9	96415473	96415473	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acccctagaatgtccagcttCgtggagccacctgacattgt	9	13	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:96415473C>T	uc004aub.2	+	6	762	c.615C>T	c.(613-615)TTC>TTT	p.F205F	PHF2_uc011lug.1_Silent_p.F88F	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	205	JmjC.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		TGTCCAGCTTCGTGGAGCCAC	0.502													0	0	0	0.001168	0	6	29										T	96415473	C	T	96415473	2	4	27	1	0	0	0	0	0	0	0	1	11830	883	31	1		1	PHF2	9	96415473	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1259946	96415473	44797958	181	7434										
ZNF510	22869	broad.mit.edu	37	chr9	99522220	99522220	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtgccagttctcctgtggtCaaagagagttttcttatcac	9	9	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:99522220C>G	uc004awn.1	-	6	1081	c.892G>C	c.(892-894)GAC>CAC	p.D298H	ZNF510_uc004awo.1_Missense_Mutation_p.D298H	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTCCTGTGGTCAAAGAGAGTT	0.358													0	0	0	0.00308	0	8	112										G	99522220	C	G	99522220	3	3	27	1	0	0	0	0	1	0	0	0	17951	826	29	1	1163	1	ZNF510	9	99522220	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3106747	99522220	41691211	182	7435										
UGCG	7357	broad.mit.edu	37	chr9	114691868	114691868	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aggaatgtcttgtttaatgaGaaaagatgtgttggatcaag	12	2	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:114691868G>A	uc004bft.2	+	6	937	c.647G>A	c.(646-648)AGA>AAA	p.R216K		NM_003358	NP_003349	Q16739	CEGT_HUMAN	ceramide glucosyltransferase	216	Lumenal (Potential).				epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)	TGTTTAATGAGAAAAGATGTG	0.393													0	0	0	0.01441	0	65	79										A	114691868	G	A	114691868	3	1	27	1	0	0	0	0	1	0	0	0	16936	942	33	1	669	1	UGCG	9	114691868	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	15169648	114691868	26521563	183	7436										
GPR21	2844	broad.mit.edu	37	chr9	125797112	125797112	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtggtcccttctttatcactCctccatcacccccttccagt	4	18	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:125797112C>T	uc011lzk.1	+	1	267	c.267C>T	c.(265-267)CTC>CTT	p.L89L	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	89	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CTTTATCACTCCTCCATCACC	0.463													0	0	0	0.003271	0	36	44										T	125797112	C	T	125797112	2	4	27	1	0	0	0	0	0	0	0	1	6681	842	30	1		1	GPR21	9	125797112	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	11105244	125797112	15416319	184	7437										
TSC1	7248	broad.mit.edu	37	chr9	135786887	135786887	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgatggggaactcagagtctGaggtagctgccctggcatat	14	9	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:135786887G>A	uc004cca.2	-	10	1216	c.982C>T	c.(982-984)CAG>TAG	p.Q328*	TSC1_uc004ccb.3_Nonsense_Mutation_p.Q328*|TSC1_uc011mcq.1_Nonsense_Mutation_p.Q277*|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_Nonsense_Mutation_p.Q207*|TSC1_uc004ccc.1_Nonsense_Mutation_p.Q328*|TSC1_uc004ccd.2_Nonsense_Mutation_p.Q328*|TSC1_uc004cce.1_Nonsense_Mutation_p.Q328*	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	328					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CTCAGAGTCTGAGGTAGCTGC	0.502			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.004289	0	36	72										A	135786887	G	A	135786887	4	1	27	1	0	0	0	0	0	1	0	0	16602	1299	45	1	2568	1	TSC1	9	135786887	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9989775	135786887	5426544	185	7438										
COL5A1	1289	broad.mit.edu	37	chr9	137676852	137676852	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagggggagatcggcccaccCggtcccaggggagaagatgg	18	11	0	3	rs144775947		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:137676852C>T	uc004cfe.2	+	30	2884	c.2502C>T	c.(2500-2502)CCC>CCT	p.P834P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	834	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TCGGCCCACCCGGTCCCAGGG	0.617													0	0	0	0.000602	0	3	45										T	137676852	C	T	137676852	2	4	27	1	0	0	0	0	0	0	0	1	3696	639	23	2		2	COL5A1	9	137676852	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1889965	137676852	3536579	186	7439										
OBP2A	29991	broad.mit.edu	37	chr9	138439763	138439763	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	caggagctgcccgggacggaCgactacgtcttttactgcaa	12	12	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:138439763C>T	uc004cgb.2	+	4	366	c.324C>T	c.(322-324)GAC>GAT	p.D108D	OBP2A_uc004cgc.2_Silent_p.D108D|OBP2A_uc010nau.2_RNA|OBP2A_uc010nav.2_Nonsense_Mutation_p.R64*	NM_014582	NP_055397	Q9NY56	OBP2A_HUMAN	odorant binding protein 2A precursor	108					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CCGGGACGGACGACTACGTCT	0.612													0	0	0	0.004672	0	3	21										T	138439763	C	T	138439763	2	4	27	1	0	0	0	0	0	0	0	1	10810	535	19	2		2	OBP2A	9	138439763	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	762911	138439763	2773668	187	7440										
PMPCA	23203	broad.mit.edu	37	chr9	139313052	139313052	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgttgaacatgatgatgggcGgaggtggctccttctcggct	15	8	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr9:139313052G>A	uc004chl.2	+	9	1041	c.1036G>A	c.(1036-1038)GGA>AGA	p.G346R	PMPCA_uc010nbl.2_Missense_Mutation_p.G246R|PMPCA_uc011mdz.1_Missense_Mutation_p.G215R|PMPCA_uc004chm.1_Missense_Mutation_p.G96R|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	346					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GATGATGGGCGGAGGTGGCTC	0.602													0	0	0	0.000602	0	3	45										A	139313052	G	A	139313052	3	1	27	1	0	0	0	0	1	0	0	0	12140	1117	39	2	1070	2	PMPCA	9	139313052	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	873289	139313052	1900379	188	7441										
AKR1C4	1109	broad.mit.edu	37	chr10	5248277	5248277	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atgcaggattggccaagtccAtcggggtgtcaaacttcaac	11	10	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:5248277A>T	uc001ihw.2	+	5	520	c.487A>T	c.(487-489)ATC>TTC	p.I163F		NM_001818	NP_001809	P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	163					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			ovary(1)	1					NADH(DB00157)	GGCCAAGTCCATCGGGGTGTC	0.507													0	0	0	0.008291	0	11	126										T	5248277	A	T	5248277	3	4	27	1	0	0	0	0	1	0	0	0	472	217	8	5	505	5	AKR1C4	10	5248277	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08		5248277	130286470	189	7442										
UPF2	26019	broad.mit.edu	37	chr10	12071355	12071355	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgttgttctgtaatagttttTagtttcttgacaaaagcagt	8	4	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:12071355T>C	uc001ila.2	-	2	1008	c.534A>G	c.(532-534)CTA>CTG	p.L178L	UPF2_uc001ilb.2_Silent_p.L178L|UPF2_uc001ilc.2_Silent_p.L178L|UPF2_uc009xiz.1_Silent_p.L178L	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	178	MIF4G 1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TAATAGTTTTTAGTTTCTTGA	0.408													0	0	0	0.01441	0	62	157										C	12071355	T	C	12071355	2	2	27	1	0	0	0	0	0	0	0	1	17001	1741	61	5		5	UPF2	10	12071355	Silent	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	6823078	12071355	123463392	190	7443										
ZNF438	220929	broad.mit.edu	37	chr10	31138355	31138355	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtggtggagggtatcttatCacagtcggccttaggtcctg	14	8	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:31138355C>A	uc010qdz.1	-	7	1414	c.979G>T	c.(979-981)GAT>TAT	p.D327Y	ZNF438_uc001ivn.2_Missense_Mutation_p.D278Y|ZNF438_uc010qdy.1_Missense_Mutation_p.D317Y|ZNF438_uc001ivo.3_5'UTR|ZNF438_uc009xlg.2_Missense_Mutation_p.D327Y|ZNF438_uc001ivp.3_Missense_Mutation_p.D317Y|ZNF438_uc010qea.1_Missense_Mutation_p.D327Y|ZNF438_uc010qeb.1_Missense_Mutation_p.D327Y|ZNF438_uc010qec.1_5'UTR	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	327					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GGTATCTTATCACAGTCGGCC	0.468													1	0	0.00829132	0.008291	0.00853629	11	167										A	31138355	C	A	31138355	3	1	27	1	0	0	0	0	1	0	0	0	17907	826	29	3	1515	3	ZNF438	10	31138355	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	19067000	31138355	104396392	191	7444										
ALOX5	240	broad.mit.edu	37	chr10	45907638	45907638	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cttctcctttctcatgctcaGatggatggagtggaaccctg	10	11	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:45907638G>A	uc001jce.2	+	4	531	c.432_splice	c.e4-1	p.R144_splice	ALOX5_uc009xmt.2_Splice_Site_p.R144_splice|ALOX5_uc010qfg.1_Splice_Site_p.R144_splice	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase						hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CTCATGCTCAGATGGATGGAG	0.512													0	0	0	0.012319	0	23	66										A	45907638	G	A	45907638	5	1	27	1	0	0	0	0	0	0	1	0	540	956	33	1	445	1	ALOX5	10	45907638	Splice_Site	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	14769283	45907638	89627109	192	7445										
CHAT	1103	broad.mit.edu	37	chr10	50857602	50857602	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcagactccgtcagcgagctCcccgccccccggaggctgcg	13	19	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:50857602C>T	uc001jhz.2	+	10	1584	c.1431C>T	c.(1429-1431)CTC>CTT	p.L477L	CHAT_uc001jhv.1_Silent_p.L359L|CHAT_uc001jhx.1_Silent_p.L359L|CHAT_uc001jhy.1_Silent_p.L359L|CHAT_uc001jia.2_Silent_p.L359L|CHAT_uc010qgs.1_Silent_p.L359L	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	477					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TCAGCGAGCTCCCCGCCCCCC	0.617													0	0	0	0.009096	0	4	69										T	50857602	C	T	50857602	2	4	27	1	0	0	0	0	0	0	0	1	3313	842	30	1		1	CHAT	10	50857602	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4949964	50857602	84677145	193	7446										
PCDH15	65217	broad.mit.edu	37	chr10	55600095	55600095	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cttacttaaaaagctcatttCtatcgatggctctgttggtt	7	8	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:55600095C>G	uc001jju.1	-	29	4363	c.3968G>C	c.(3967-3969)AGA>ACA	p.R1323T	PCDH15_uc010qhq.1_Missense_Mutation_p.R1328T|PCDH15_uc010qhr.1_Missense_Mutation_p.R1323T|PCDH15_uc010qhs.1_Missense_Mutation_p.R1335T|PCDH15_uc010qht.1_Missense_Mutation_p.R1330T|PCDH15_uc010qhu.1_Missense_Mutation_p.R1323T|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1323T|PCDH15_uc010qhw.1_Missense_Mutation_p.R1286T|PCDH15_uc010qhx.1_Missense_Mutation_p.R1252T|PCDH15_uc010qhy.1_Missense_Mutation_p.R1328T|PCDH15_uc010qhz.1_Missense_Mutation_p.R1323T|PCDH15_uc010qia.1_Missense_Mutation_p.R1301T|PCDH15_uc010qib.1_Missense_Mutation_p.R1301T	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1323	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AAGCTCATTTCTATCGATGGC	0.408										HNSCC(58;0.16)			0	0	0	0.011902	0	44	117										G	55600095	C	G	55600095	3	3	27	1	0	0	0	0	1	0	0	0	11511	913	32	1	3538	1	PCDH15	10	55600095	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4742493	55600095	79934652	194	7447										
CTNNA3	29119	broad.mit.edu	37	chr10	68040318	68040318	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgattatcatccaacacattCaatgagcttttgcttaaggc	6	9	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:68040318C>T	uc009xpn.1	-	13	1917	c.1794G>A	c.(1792-1794)TTG>TTA	p.L598L	CTNNA3_uc001jmw.2_Silent_p.L598L	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	598					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CCAACACATTCAATGAGCTTT	0.343													0	0	0	0.008291	0	11	140										T	68040318	C	T	68040318	2	4	27	1	0	0	0	0	0	0	0	1	4014	825	29	1		1	CTNNA3	10	68040318	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	12440223	68040318	67494429	195	7448										
CCDC109A	90550	broad.mit.edu	37	chr10	74619017	74619017	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaacgctgtcagttcacactCaagcctatctctgactctgt	7	13	5	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:74619017C>G	uc001jtc.2	+	3	324	c.303C>G	c.(301-303)CTC>CTG	p.L101L	CCDC109A_uc009xqp.1_RNA|CCDC109A_uc009xqq.1_RNA|CCDC109A_uc010qjy.1_RNA|CCDC109A_uc009xqr.2_Silent_p.L101L|CCDC109A_uc001jtd.2_Silent_p.L52L	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	101	Mitochondrial matrix (Potential).				elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					AGTTCACACTCAAGCCTATCT	0.443													0	0	0	0.006214	0	10	194										G	74619017	C	G	74619017	2	3	27	1	0	0	0	0	0	0	0	1	2744	813	29	1		1	CCDC109A	10	74619017	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6578699	74619017	60915730	196	7449										
MYST4	23522	broad.mit.edu	37	chr10	76744917	76744917	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctggaccacaaaacgttgtAttatgatgtcgagccattcc	8	11	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:76744917A>G	uc001jwn.1	+	12	2946	c.2453A>G	c.(2452-2454)TAT>TGT	p.Y818C	MYST4_uc001jwm.1_Missense_Mutation_p.Y526C|MYST4_uc001jwo.1_Missense_Mutation_p.Y526C|MYST4_uc001jwp.1_Missense_Mutation_p.Y635C	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	818	Catalytic.|Interaction with BRPF1.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					AAAACGTTGTATTATGATGTC	0.383			T	CREBBP	AML								0	0	0	0.004007	0	16	101										G	76744917	A	G	76744917	3	3	27	1	0	0	0	0	1	0	0	0	10105	449	16	5	2491	5	MYST4	10	76744917	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	2125900	76744917	58789830	197	7450										
ANXA11	311	broad.mit.edu	37	chr10	81929059	81929059	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggtagccagccccaggggccCcagggtacaggttgggcatg	17	12	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:81929059C>T	uc001kbq.1	-	6	1052	c.227G>A	c.(226-228)GGG>GAG	p.G76E	ANXA11_uc010qlx.1_Missense_Mutation_p.G176E|ANXA11_uc001kbr.1_Missense_Mutation_p.G76E|ANXA11_uc001kbs.1_Missense_Mutation_p.G76E|ANXA11_uc001kbt.1_Missense_Mutation_p.G76E|ANXA11_uc010qly.1_Missense_Mutation_p.G43E|ANXA11_uc009xsq.1_Missense_Mutation_p.G76E|ANXA11_uc001kbu.1_Missense_Mutation_p.G76E	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	76					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			CCCAGGGGCCCCAGGGTACAG	0.652													0	0	0	0.001168	0	5	13										T	81929059	C	T	81929059	3	4	27	1	0	0	0	0	1	0	0	0	716	623	22	2	1338	2	ANXA11	10	81929059	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5184142	81929059	53605688	198	7451										
C10orf78	119392	broad.mit.edu	37	chr10	105882813	105882813	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcaggcctctgcgaatccatCatctccctatacaaatagtt	5	13	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:105882813C>T	uc001kxu.2	+	2	117	c.104C>T	c.(103-105)TCA>TTA	p.S35L	C10orf78_uc001kxs.2_Missense_Mutation_p.S22L|C10orf78_uc001kxt.2_5'UTR|C10orf78_uc001kxv.2_Missense_Mutation_p.S97L	NM_001002759	NP_001002759	Q86XK3	SFR1_HUMAN	hypothetical protein LOC119392 isoform a	35					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;1.31e-09)|all cancers(201;3.84e-08)|BRCA - Breast invasive adenocarcinoma(275;0.014)		GCGAATCCATCATCTCCCTAT	0.398													0	0	0	0.009718	0	44	92										T	105882813	C	T	105882813	3	4	27	1	0	0	0	0	1	0	0	0	1617	838	29	1	110	1	C10orf78	10	105882813	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	23953754	105882813	29651934	199	7452										
NRAP	4892	broad.mit.edu	37	chr10	115355468	115355468	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctgtgcagggattctgcatCtccagatctatacatgcgct	9	11	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:115355468C>T	uc001laj.2	-	38	4614	c.4450G>A	c.(4450-4452)GAT>AAT	p.D1484N	NRAP_uc009xyb.2_Missense_Mutation_p.D273N|NRAP_uc001lak.2_Missense_Mutation_p.D1449N|NRAP_uc001lal.3_Missense_Mutation_p.D1484N	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1484						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GATTCTGCATCTCCAGATCTA	0.512													0	0	0	0.008291	0	10	144										T	115355468	C	T	115355468	3	4	27	1	0	0	0	0	1	0	0	0	10638	913	32	1	762	1	NRAP	10	115355468	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9472655	115355468	20179279	200	7453										
FAM45A	404636	broad.mit.edu	37	chr10	120879939	120879939	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgtggtgtatcaccccaagAtagaagcggtccaggagttc	12	9	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:120879939A>G	uc001ldw.2	+	5	612	c.568A>G	c.(568-570)ATA>GTA	p.I190V	FAM45A_uc010qsv.1_Missense_Mutation_p.I182V|FAM45A_uc010qsw.1_Missense_Mutation_p.I39V|FAM45A_uc010qsx.1_Intron|FAM45A_uc010qsy.1_Missense_Mutation_p.I117V|FAM45A_uc010qsz.1_Missense_Mutation_p.I79V	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	190										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		TCACCCCAAGATAGAAGCGGT	0.398													0	0	0	0.001168	0	5	77										G	120879939	A	G	120879939	3	3	27	1	0	0	0	0	1	0	0	0	5564	333	12	5	586	5	FAM45A	10	120879939	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	5524471	120879939	14654808	201	7454										
BAG3	9531	broad.mit.edu	37	chr10	121431904	121431904	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccggtgatacacgagcagaaCgttacccggccagcagccca	11	15	0	2	rs138078305	byFrequency	TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:121431904C>T	uc001lem.2	+	3	951	c.645C>T	c.(643-645)AAC>AAT	p.N215N	BAG3_uc001lel.2_Silent_p.N215N	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	215					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		ACGAGCAGAACGTTACCCGGC	0.652													0	0	0	0.010504	0	22	70										T	121431904	C	T	121431904	2	4	27	1	0	0	0	0	0	0	0	1	1288	535	19	2		2	BAG3	10	121431904	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	551965	121431904	14102843	202	7455										
MKI67	4288	broad.mit.edu	37	chr10	129905874	129905874	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtttcccctgatgtctgtgtGagcttcttcagggctgagag	13	9	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr10:129905874G>A	uc001lke.2	-	13	4425	c.4230C>T	c.(4228-4230)CTC>CTT	p.L1410L	MKI67_uc001lkf.2_Silent_p.L1050L|MKI67_uc009yav.1_Silent_p.L985L|MKI67_uc009yaw.1_Silent_p.L560L	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1410	16 X 122 AA approximate repeats.|4.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ATGTCTGTGTGAGCTTCTTCA	0.498													0	0	0	0.013114	0	43	317										A	129905874	G	A	129905874	2	1	27	1	0	0	0	0	0	0	0	1	9598	1277	45	1		1	MKI67	10	129905874	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8473970	129905874	5628873	203	7456										
OR51B6	390058	broad.mit.edu	37	chr11	5372785	5372785	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttccagcttactggcttcccAggcatggagaaggcacatca	10	12	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:5372785A>C	uc010qzb.1	+	1	48	c.48A>C	c.(46-48)CCA>CCC	p.P16P	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGCTTCCCAGGCATGGAGA	0.453													0	0	0	0.004482	0	6	39										C	5372785	A	C	5372785	2	2	27	1	0	0	0	0	0	0	0	1	11092	175	7	5		5	OR51B6	11	5372785	Silent	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08		5372785	129633731	204	7457										
MICAL2	9645	broad.mit.edu	37	chr11	12248645	12248645	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccatttctaataactatctCaacctcacatttccaaggaa	2	12	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:12248645C>G	uc001mjz.2	+	15	2250	c.1962C>G	c.(1960-1962)CTC>CTG	p.L654L	MICAL2_uc010rch.1_Silent_p.L654L|MICAL2_uc001mka.2_Silent_p.L654L|MICAL2_uc010rci.1_Silent_p.L654L|MICAL2_uc001mkb.2_Silent_p.L654L|MICAL2_uc001mkc.2_Silent_p.L654L|MICAL2_uc001mkd.2_Silent_p.L483L|MICAL2_uc010rcj.1_Silent_p.L56L	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	654						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		ATAACTATCTCAACCTCACAT	0.443													0	0	0	0.013537	0	12	58										G	12248645	C	G	12248645	2	3	27	1	0	0	0	0	0	0	0	1	9570	813	29	1		1	MICAL2	11	12248645	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6875860	12248645	122757871	205	7458										
COPB1	1315	broad.mit.edu	37	chr11	14502617	14502617	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctaagtctggtgtgctcaaTactcttaggatatccataac	7	9	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:14502617T>C	uc001mli.2	-	9	1291	c.984A>G	c.(982-984)GTA>GTG	p.V328V	COPB1_uc001mlg.2_Silent_p.V328V|COPB1_uc001mlh.2_Silent_p.V328V	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	328	HEAT 5.				COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						GTGTGCTCAATACTCTTAGGA	0.363													0	0	0	0.008871	0	19	141										C	14502617	T	C	14502617	2	2	27	1	0	0	0	0	0	0	0	1	3728	1393	49	5		5	COPB1	11	14502617	Silent	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	2253972	14502617	120503899	206	7459										
GTF2H1	2965	broad.mit.edu	37	chr11	18361114	18361114	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tatgggctttgttttaggctGatgtccggccccaaactgat	11	9	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:18361114G>A	uc001moi.2	+	6	1211	c.517G>A	c.(517-519)GAT>AAT	p.D173N	GTF2H1_uc001moh.2_Missense_Mutation_p.D173N|GTF2H1_uc009yhm.2_Missense_Mutation_p.D57N	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	173					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						GTTTTAGGCTGATGTCCGGCC	0.423								NER					0	0	0	0.008291	0	9	92										A	18361114	G	A	18361114	3	1	27	1	0	0	0	0	1	0	0	0	6860	1290	45	1	531	1	GTF2H1	11	18361114	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3858497	18361114	116645402	207	7460										
CCDC34	91057	broad.mit.edu	37	chr11	27384539	27384539	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agctctggtggccaaggggaGacaacagcgacctggtggaa	16	9	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:27384539G>C	uc001mrh.1	-	1	257	c.203C>G	c.(202-204)TCT>TGT	p.S68C	CCDC34_uc001mri.1_Missense_Mutation_p.S68C	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	68											0						GCCAAGGGGAGACAACAGCGA	0.637													0	0	0	0.001984	0	7	95										C	27384539	G	C	27384539	3	2	27	1	0	0	0	0	1	0	0	0	2807	942	33	1	1026	1	CCDC34	11	27384539	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	9023425	27384539	107621977	208	7461										
METT5D1	196074	broad.mit.edu	37	chr11	28232683	28232683	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaggagtcagatattgttctCtatgccttggacagagaccc	10	9	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:28232683C>G	uc001msh.2	+	4	800	c.345C>G	c.(343-345)CTC>CTG	p.L115L	METT5D1_uc001msg.2_Silent_p.L115L|METT5D1_uc001mse.2_Silent_p.L115L	NM_001113528	NP_001107000	A6NJ78	MET15_HUMAN	methyltransferase 5 domain containing 1 isoform	115							methyltransferase activity				0						ATATTGTTCTCTATGCCTTGG	0.378													0	0	0	0.001168	0	6	103										G	28232683	C	G	28232683	2	3	27	1	0	0	0	0	0	0	0	1	9492	900	32	1		1	METT5D1	11	28232683	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	848144	28232683	106773833	209	7462										
EIF3M	10480	broad.mit.edu	37	chr11	32622318	32622318	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaaataaggaaatttcttttGacacaatgcagcaagaactt	6	6	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:32622318G>C	uc001mtu.2	+	9	926	c.883G>C	c.(883-885)GAC>CAC	p.D295H	EIF3M_uc010ref.1_Missense_Mutation_p.D163H	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,	295	PCI.					eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					AATTTCTTTTGACACAATGCA	0.343													0	0	0	0.006122	0	17	156										C	32622318	G	C	32622318	3	2	27	1	0	0	0	0	1	0	0	0	5023	1290	45	1	917	1	EIF3M	11	32622318	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4389635	32622318	102384198	210	7463										
PRPF19	27339	broad.mit.edu	37	chr11	60671325	60671325	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acatgggtgctccggcacttCgttagagactgtagagaaaa	12	8	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:60671325C>T	uc001nqf.2	-	2	235	c.28G>A	c.(28-30)GAA>AAA	p.E10K		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	10	U-box.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						TCCGGCACTTCGTTAGAGACT	0.507													0	0	0	0.008871	0	18	99										T	60671325	C	T	60671325	3	4	27	1	0	0	0	0	1	0	0	0	12564	893	31	1	1546	1	PRPF19	11	60671325	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	28049007	60671325	74335191	211	7464										
SYT7	9066	broad.mit.edu	37	chr11	61291406	61291406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gagacaagagcagctcccctCggctcccctgggaggcacga	13	15	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:61291406C>T	uc001nrv.2	-	7	806	c.800G>A	c.(799-801)CGA>CAA	p.R267Q	SYT7_uc009ynr.2_Missense_Mutation_p.R342Q	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	267	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						CAGCTCCCCTCGGCTCCCCTG	0.607													0	0	0	0.00245	0	13	205										T	61291406	C	T	61291406	3	4	27	1	0	0	0	0	1	0	0	0	15476	884	31	1	423	1	SYT7	11	61291406	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	620081	61291406	73715110	212	7465										
CD248	57124	broad.mit.edu	37	chr11	66082774	66082774	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agctgggtggcctgggttctGaggacaagggcatctggggc	19	8	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:66082774G>A	uc001ohm.1	-	1	1742	c.1725C>T	c.(1723-1725)CTC>CTT	p.L575L		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	575	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	CCTGGGTTCTGAGGACAAGGG	0.607													0	0	0	0.00333	0	23	143										A	66082774	G	A	66082774	2	1	27	1	0	0	0	0	0	0	0	1	2989	1277	45	1		1	CD248	11	66082774	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4791368	66082774	68923742	213	7466										
B3GNT1	11041	broad.mit.edu	37	chr11	66113603	66113603	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatcttattgtgctgattttCagcctccttttggggatgga	11	7	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:66113603C>T	uc001ohr.2	-	2	1310	c.1165G>A	c.(1165-1167)GAA>AAA	p.E389K	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	389	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						TGCTGATTTTCAGCCTCCTTT	0.502													0	0	0	0.01441	0	77	140										T	66113603	C	T	66113603	3	4	27	1	0	0	0	0	1	0	0	0	1256	835	29	1	86	1	B3GNT1	11	66113603	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	30829	66113603	68892913	214	7467										
SHANK2	22941	broad.mit.edu	37	chr11	70319029	70319029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgttcattctgtgcccgactCgagttaccccaagatcgatg	9	12	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:70319029C>T	uc001oqc.2	-	22	5573	c.5495G>A	c.(5494-5496)CGA>CAA	p.R1832Q	SHANK2_uc010rqn.1_Missense_Mutation_p.R1244Q|SHANK2_uc001opz.2_Missense_Mutation_p.R1237Q|uc009ysn.1_5'UTR|SHANK2_uc001opy.2_Missense_Mutation_p.R168Q	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1453	SAM.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GTGCCCGACTCGAGTTACCCC	0.488													0	0	0	0.01441	0	74	180										T	70319029	C	T	70319029	3	4	27	1	0	0	0	0	1	0	0	0	14265	884	31	1	58	1	SHANK2	11	70319029	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4205426	70319029	64687487	215	7468										
SYTL2	54843	broad.mit.edu	37	chr11	85447612	85447612	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	catttttagtttgttgtgatGagtgaccttctggcaacttg	10	6	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:85447612G>A	uc010rth.1	-	5	791	c.515C>T	c.(514-516)TCA>TTA	p.S172L	SYTL2_uc010rtg.1_Missense_Mutation_p.S173L|SYTL2_uc010rti.1_Missense_Mutation_p.S172L|SYTL2_uc010rtj.1_Missense_Mutation_p.S124L|SYTL2_uc001pbf.3_Missense_Mutation_p.S172L|SYTL2_uc010rtf.1_Missense_Mutation_p.S30L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	172					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TTGTTGTGATGAGTGACCTTC	0.313													0	0	0	0.000602	0	4	70										A	85447612	G	A	85447612	3	1	27	1	0	0	0	0	1	0	0	0	15480	1294	45	1	4826	1	SYTL2	11	85447612	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	15128583	85447612	49558904	216	7469										
C11orf73	51501	broad.mit.edu	37	chr11	86048472	86048472	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaatattgtccgaactccatCtgttgctcagattggaattt	8	8	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:86048472C>G	uc001pbu.2	+	3	558	c.320C>G	c.(319-321)TCT>TGT	p.S107C	C11orf73_uc001pbt.2_Missense_Mutation_p.S107C|C11orf73_uc010rto.1_RNA|C11orf73_uc010rtp.1_Missense_Mutation_p.S8C|C11orf73_uc001pbv.2_RNA	NM_016401	NP_057485	Q53FT3	CK073_HUMAN	lethal, Chr 7, Rinchik 6	107						cytoplasm					0		Acute lymphoblastic leukemia(157;1.17e-07)|all_hematologic(158;0.000556)				CGAACTCCATCTGTTGCTCAG	0.403													0	0	0	0.01441	0	51	272										G	86048472	C	G	86048472	3	3	27	1	0	0	0	0	1	0	0	0	1661	913	32	1	330	1	C11orf73	11	86048472	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	600860	86048472	48958044	217	7470										
FAT3	120114	broad.mit.edu	37	chr11	92533128	92533128	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctctattgatgcagactcaGaaaacaataaaatggtacat	6	7	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:92533128G>C	uc001pdj.3	+	9	6966	c.6949G>C	c.(6949-6951)GAA>CAA	p.E2317Q		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2317	Cadherin 21.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGCAGACTCAGAAAACAATAA	0.388										TCGA Ovarian(4;0.039)			0	0	0	0.000602	0	5	39										C	92533128	G	C	92533128	3	2	27	1	0	0	0	0	1	0	0	0	5691	943	33	1	6983	1	FAT3	11	92533128	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	6484656	92533128	42473388	218	7471										
MMP27	64066	broad.mit.edu	37	chr11	102564639	102564639	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aattgtctgtaaacttacctCcagcaccaaatgcccacaaa	4	13	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:102564639C>G	uc001phd.1	-	8	1214	c.1191G>C	c.(1189-1191)TGG>TGC	p.W397C		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	397	Hemopexin-like 3.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		AAACTTACCTCCAGCACCAAA	0.353													0	0	0	0.000602	0	4	169										G	102564639	C	G	102564639	3	3	27	1	0	0	0	0	1	0	0	0	9664	856	30	1	362	1	MMP27	11	102564639	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	10031511	102564639	32441877	219	7472										
DYNC2H1	79659	broad.mit.edu	37	chr11	103086469	103086469	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggctggtgtatctaaactaaAtgaagctaaagctcttgtgg	11	6	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:103086469A>C	uc001pho.2	+	55	8858	c.8714A>C	c.(8713-8715)AAT>ACT	p.N2905T	DYNC2H1_uc001phn.1_Missense_Mutation_p.N2905T|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2905	Potential.|Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCTAAACTAAATGAAGCTAAA	0.343													0	0	0	0.004672	0	3	19										C	103086469	A	C	103086469	3	2	27	1	0	0	0	0	1	0	0	0	4846	101	4	5	8932	5	DYNC2H1	11	103086469	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	521830	103086469	31920047	220	7473										
CARD16	114769	broad.mit.edu	37	chr11	104915124	104915124	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtcactgacccttacctgctGagagtcccagcgtctctgcc	9	16	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:104915124G>A	uc001pip.1	-	2	296	c.269C>T	c.(268-270)TCA>TTA	p.S90L	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Missense_Mutation_p.S90L	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	90	CARD.				regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						CTTACCTGCTGAGAGTCCCAG	0.453													0	0	0	0.01441	0	50	138										A	104915124	G	A	104915124	3	1	27	1	0	0	0	0	1	0	0	0	2647	1294	45	1	356	1	CARD16	11	104915124	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1828655	104915124	30091392	221	7474										
MLL	4297	broad.mit.edu	37	chr11	118374132	118374132	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagctccacccatgcaagtaGaaggatctgccaaggaatta	9	10	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:118374132G>C	uc001pta.2	+	27	7539	c.7516G>C	c.(7516-7518)GAA>CAA	p.E2506Q	MLL_uc001ptb.2_Missense_Mutation_p.E2509Q	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2506					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CATGCAAGTAGAAGGATCTGC	0.448			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.006214	0	9	72										C	118374132	G	C	118374132	3	2	27	1	0	0	0	0	1	0	0	0	9620	943	33	1	7622	1	MLL	11	118374132	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	13459008	118374132	16632384	222	7475										
OR4D5	219875	broad.mit.edu	37	chr11	123810416	123810416	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tttgttttcttcactgttttCtctgctgtgtattttatgac	6	7	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:123810416C>A	uc001pzk.1	+	1	93	c.93C>A	c.(91-93)TTC>TTA	p.F31L		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCACTGTTTTCTCTGCTGTGT	0.463													1	0	4.96729e-08	0.008871	5.34485e-08	19	154										A	123810416	C	A	123810416	3	1	27	1	0	0	0	0	1	0	0	0	11057	912	32	3	95	3	OR4D5	11	123810416	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5436284	123810416	11196100	223	7476										
OR10G8	219869	broad.mit.edu	37	chr11	123900608	123900608	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agtggcagggctatctccttCcacagctgcatggctcagct	11	13	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:123900608C>T	uc001pzp.1	+	1	279	c.279C>T	c.(277-279)TTC>TTT	p.F93F		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTATCTCCTTCCACAGCTGCA	0.522													0	0	0	0.008291	0	9	134										T	123900608	C	T	123900608	2	4	27	1	0	0	0	0	0	0	0	1	10903	854	30	1		1	OR10G8	11	123900608	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	90192	123900608	11105908	224	7477										
KCNJ5	3762	broad.mit.edu	37	chr11	128781390	128781390	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	caggagacctaccggtacctGagtgacctcttcaccaccct	8	16	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr11:128781390G>C	uc001qet.2	+	2	536	c.222G>C	c.(220-222)CTG>CTC	p.L74L	KCNJ5_uc009zck.2_Silent_p.L74L|KCNJ5_uc001qew.2_Silent_p.L74L	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	74	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	ACCGGTACCTGAGTGACCTCT	0.577													0	0	0	0.001168	0	4	134										C	128781390	G	C	128781390	2	2	27	1	0	0	0	0	0	0	0	1	8054	1277	45	1		1	KCNJ5	11	128781390	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4880782	128781390	6225126	225	7478										
FOXM1	2305	broad.mit.edu	37	chr12	2968590	2968590	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggagattgggacgaatcctcCcaggagtgagatgattcctc	13	9	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:2968590C>G	uc001qlf.2	-	9	1771	c.1506G>C	c.(1504-1506)TGG>TGC	p.W502C	uc001qld.2_Intron|FOXM1_uc001qle.2_Missense_Mutation_p.W540C|FOXM1_uc001qlg.2_Missense_Mutation_p.W487C|FOXM1_uc009zea.2_Missense_Mutation_p.W487C|FOXM1_uc009zeb.2_Missense_Mutation_p.W486C	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	502	Glu/Pro/Ser/Thr-rich.				cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			ACGAATCCTCCCAGGAGTGAG	0.547													0	0	0	0.001168	0	5	201										G	2968590	C	G	2968590	3	3	27	1	0	0	0	0	1	0	0	0	6018	624	22	4	789	4	FOXM1	12	2968590	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		2968590	130883305	226	7479										
CHD4	1108	broad.mit.edu	37	chr12	6680126	6680126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcacagcaactgggggaattCgggcaatggtagctgggagt	16	7	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:6680126C>T	uc001qpo.2	-	39	5794	c.5630G>A	c.(5629-5631)CGA>CAA	p.R1877Q	CHD4_uc001qpn.2_Missense_Mutation_p.R1870Q|CHD4_uc001qpp.2_Missense_Mutation_p.R1902Q|NOP2_uc001qph.1_5'Flank|NOP2_uc001qpi.1_5'Flank|NOP2_uc001qpj.1_5'Flank|NOP2_uc001qpk.1_5'Flank|NOP2_uc001qpl.1_5'Flank|NOP2_uc001qpm.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1877	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TGGGGGAATTCGGGCAATGGT	0.537													0	0	0	0.01441	0	54	333										T	6680126	C	T	6680126	3	4	27	1	0	0	0	0	1	0	0	0	3327	884	31	1	116	1	CHD4	12	6680126	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3711536	6680126	127171769	227	7480										
CHD4	1108	broad.mit.edu	37	chr12	6686986	6686986	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tagaaatttattcttgatctCtaagaaattgccacggttca	6	7	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:6686986C>G	uc001qpo.2	-	37	5490	c.5326G>C	c.(5326-5328)GAG>CAG	p.E1776Q	CHD4_uc001qpn.2_Missense_Mutation_p.E1769Q|CHD4_uc001qpp.2_Missense_Mutation_p.E1801Q|uc001qpq.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1776	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TTCTTGATCTCTAAGAAATTG	0.463													0	0	0	0.001855	0	11	163										G	6686986	C	G	6686986	3	3	27	1	0	0	0	0	1	0	0	0	3327	922	32	1	428	1	CHD4	12	6686986	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6860	6686986	127164909	228	7481										
ABCC9	10060	broad.mit.edu	37	chr12	22015985	22015985	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tatgccacagagtacctgttCctactgaaaaatgaaaaaga	7	8	0	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:22015985C>T	uc001rfi.1	-	18	2261	c.2241G>A	c.(2239-2241)AGG>AGA	p.R747R	ABCC9_uc001rfh.2_Silent_p.R747R|ABCC9_uc001rfj.1_Silent_p.R711R	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	747	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTACCTGTTCCTACTGAAAA	0.323													0	0	0	0.000602	0	5	74										T	22015985	C	T	22015985	2	4	27	1	0	0	0	0	0	0	0	1	59	854	30	1		1	ABCC9	12	22015985	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	15328999	22015985	111835910	229	7482										
ADAMTS20	80070	broad.mit.edu	37	chr12	43826585	43826585	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atccttgaccacattgggatGaacattcacttttgccaata	6	10	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:43826585G>T	uc010skx.1	-	20	2750	c.2750C>A	c.(2749-2751)TCA>TAA	p.S917*	ADAMTS20_uc001rno.1_Nonsense_Mutation_p.S71*|ADAMTS20_uc001rnp.1_Nonsense_Mutation_p.S71*	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	917	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACATTGGGATGAACATTCACT	0.368													1	0	0.000673444	0.008291	0.000696507	10	187										T	43826585	G	T	43826585	4	4	27	1	0	0	0	0	0	1	0	0	266	1294	45	3	3061	3	ADAMTS20	12	43826585	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	21810600	43826585	90025310	230	7483										
BAZ2A	11176	broad.mit.edu	37	chr12	56995427	56995427	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cattgcagggcatctgggctGagatgttaaaccagagtgct	13	8	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:56995427G>C	uc001slq.1	-	20	4174	c.3980C>G	c.(3979-3981)TCA>TGA	p.S1327*	BAZ2A_uc001slp.1_Nonsense_Mutation_p.S1325*|BAZ2A_uc001slo.1_Nonsense_Mutation_p.S155*|BAZ2A_uc009zov.1_Nonsense_Mutation_p.S297*|BAZ2A_uc009zow.1_Nonsense_Mutation_p.S1295*	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1327	Pro-rich.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						CATCTGGGCTGAGATGTTAAA	0.602													0	0	0	0.01441	0	51	118										C	56995427	G	C	56995427	4	2	27	1	0	0	0	0	0	1	0	0	1331	1294	45	1	1777	1	BAZ2A	12	56995427	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	13168842	56995427	76856468	231	7484										
FGD6	55785	broad.mit.edu	37	chr12	95604045	95604045	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtctgaattccccggttcttCagtgctttcactaggagtat	9	10	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:95604045C>T	uc001tdp.3	-	2	1239	c.1015G>A	c.(1015-1017)GAA>AAA	p.E339K	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	339					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CCCGGTTCTTCAGTGCTTTCA	0.408													0	0	0	0.012319	0	19	235										T	95604045	C	T	95604045	3	4	27	1	0	0	0	0	1	0	0	0	5837	835	29	1	3357	1	FGD6	12	95604045	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	38608618	95604045	38247850	232	7485										
C12orf48	55010	broad.mit.edu	37	chr12	102572447	102572447	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccttattagttcttttggaCgaagaagcagctaatgctcc	9	9	1	1	rs146074209	byFrequency	TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:102572447C>T	uc001tjf.2	+	8	1195	c.1083C>T	c.(1081-1083)GAC>GAT	p.D361D	C12orf48_uc001tjg.2_Silent_p.D280D|C12orf48_uc010swa.1_Silent_p.D438D|C12orf48_uc001tjh.2_Silent_p.D280D|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Silent_p.D76D|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	361					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						TTCTTTTGGACGAAGAAGCAG	0.368													0	0	0	0.000602	0	4	87										T	102572447	C	T	102572447	2	4	27	1	0	0	0	0	0	0	0	1	1692	535	19	2		2	C12orf48	12	102572447	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6968402	102572447	31279448	233	7486										
CKAP4	10970	broad.mit.edu	37	chr12	106632982	106632982	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagtccgcctccacttggctGactgaggctttcaggttgtc	11	12	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:106632982G>A	uc001tlk.2	-	2	1713	c.1629C>T	c.(1627-1629)GTC>GTT	p.V543V		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	543	Potential.					ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						CCACTTGGCTGACTGAGGCTT	0.527													0	0	0	0.005443	0	29	128										A	106632982	G	A	106632982	2	1	27	1	0	0	0	0	0	0	0	1	3444	1277	45	1		1	CKAP4	12	106632982	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4060535	106632982	27218913	234	7487										
SSH1	54434	broad.mit.edu	37	chr12	109182345	109182345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggctggatcctggctctcctCggggatgctggcctccagcc	14	15	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:109182345C>T	uc001tnm.2	-	15	2656	c.2569G>A	c.(2569-2571)GAG>AAG	p.E857K	SSH1_uc001tnl.2_Missense_Mutation_p.E545K	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	857					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						TGGCTCTCCTCGGGGATGCTG	0.667													0	0	0	0.009096	0	4	36										T	109182345	C	T	109182345	3	4	27	1	0	0	0	0	1	0	0	0	15183	893	31	1	584	1	SSH1	12	109182345	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2549363	109182345	24669550	235	7488										
KSR2	283455	broad.mit.edu	37	chr12	117923470	117923470	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttttggcatccctcacaacgGaatagagcgtccgtccctta	8	13	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:117923470G>C	uc001two.2	-	15	2214	c.2159C>G	c.(2158-2160)TCC>TGC	p.S720C		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	749	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCTCACAACGGAATAGAGCGT	0.448													0	0	0	0.003163	0	16	80										C	117923470	G	C	117923470	3	2	27	1	0	0	0	0	1	0	0	0	8582	1174	41	1	630	1	KSR2	12	117923470	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8741125	117923470	15928425	236	7489										
GPR133	283383	broad.mit.edu	37	chr12	131484985	131484985	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctggttggattgctctgtcaGaggtaagagaaaagaacatg	13	5	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:131484985G>C	uc001uit.3	+	9	1583	c.1024G>C	c.(1024-1026)GAG>CAG	p.E342Q	GPR133_uc010tbm.1_Missense_Mutation_p.E374Q	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	342	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGCTCTGTCAGAGGTAAGAGA	0.279													0	0	0	0.00245	0	11	93										C	131484985	G	C	131484985	3	2	27	1	0	0	0	0	1	0	0	0	6643	943	33	1	1058	1	GPR133	12	131484985	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	13561515	131484985	2366910	237	7490										
GPR133	283383	broad.mit.edu	37	chr12	131488789	131488789	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcctcccattaccgcttcccGgcccacgggcagagcttcat	8	18	1	1	rs73473278	byFrequency	TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr12:131488789G>A	uc001uit.3	+	11	1762	c.1203G>A	c.(1201-1203)CCG>CCA	p.P401P	GPR133_uc010tbm.1_Silent_p.P433P	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	401	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ACCGCTTCCCGGCCCACGGGC	0.632													0	0	0	0.001984	0	5	32										A	131488789	G	A	131488789	2	1	27	1	0	0	0	0	0	0	0	1	6643	1103	39	2		2	GPR133	12	131488789	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3804	131488789	2363106	238	7491										
TPTE2	93492	broad.mit.edu	37	chr13	20048070	20048070	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttacccttctacaaatactcGaagaagaacatccatgagaa	5	10	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:20048070G>C	uc001umd.2	-	7	587	c.376C>G	c.(376-378)CGA>GGA	p.R126G	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Missense_Mutation_p.R89G|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	126	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ACAAATACTCGAAGAAGAACA	0.259													0	0	0	0.004482	0	9	76										C	20048070	G	C	20048070	3	2	27	1	0	0	0	0	1	0	0	0	16428	1066	37	1	1252	1	TPTE2	13	20048070	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08		20048070	95121808	239	7492										
SLC7A1	6541	broad.mit.edu	37	chr13	30106971	30106971	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgggctttacctgtcaagatGagaattatgatcactgcgaa	10	7	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:30106971G>C	uc001uso.2	-	4	906	c.519C>G	c.(517-519)CTC>CTG	p.L173L		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	173	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CTGTCAAGATGAGAATTATGA	0.493													0	0	0	0.006214	0	7	100										C	30106971	G	C	30106971	2	2	27	1	0	0	0	0	0	0	0	1	14692	1277	45	1		1	SLC7A1	13	30106971	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	10058901	30106971	85062907	240	7493										
C13orf26	122046	broad.mit.edu	37	chr13	31543165	31543165	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcaagtcaaagagtaccttCagagtctttcctacaaaggt	7	10	4	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:31543165C>T	uc001uti.2	+	6	809	c.790C>T	c.(790-792)CAG>TAG	p.Q264*		NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	hypothetical protein LOC122046	264										ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)		AGAGTACCTTCAGAGTCTTTC	0.368													0	0	0	0.00308	0	7	129										T	31543165	C	T	31543165	4	4	27	1	0	0	0	0	0	1	0	0	1722	827	29	1	812	1	C13orf26	13	31543165	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1436194	31543165	83626713	241	7494										
BRCA2	675	broad.mit.edu	37	chr13	32914961	32914961	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagtttctccatatctctctCaatttcaacaagacaaacaa	2	11	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:32914961C>T	uc001uub.1	+	11	6696	c.6469C>T	c.(6469-6471)CAA>TAA	p.Q2157*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2157					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATATCTCTCTCAATTTCAACA	0.318			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008871	0	21	52										T	32914961	C	T	32914961	4	4	27	1	0	0	0	0	0	1	0	0	1499	827	29	1	6507	1	BRCA2	13	32914961	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1371796	32914961	82254917	242	7495										
NAA16	79612	broad.mit.edu	37	chr13	41910844	41910844	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gttaacttcagtaaaggctgCccacccttgtttactacttt	6	11	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:41910844C>T	uc001uyf.2	+	9	1290	c.966C>T	c.(964-966)TGC>TGT	p.C322C	NAA16_uc010tfg.1_Intron|NAA16_uc001uye.3_Silent_p.C322C|NAA16_uc001uyd.3_Intron	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	322					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						GTAAAGGCTGCCCACCCTTGT	0.318													0	0	0	0.004482	0	7	100										T	41910844	C	T	41910844	2	4	27	1	0	0	0	0	0	0	0	1	10119	747	26	2		2	NAA16	13	41910844	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	8995883	41910844	73259034	243	7496										
NALCN	259232	broad.mit.edu	37	chr13	101944589	101944589	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagtaccttcacaagccaggCgaggaagaaaatgagagtga	12	8	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:101944589C>T	uc001vox.1	-	8	1117	c.928G>A	c.(928-930)GCC>ACC	p.A310T	NALCN_uc001voy.2_Missense_Mutation_p.A25T|NALCN_uc001voz.2_Missense_Mutation_p.A310T|NALCN_uc001vpa.2_Missense_Mutation_p.A310T	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	310	Helical; Name=S6 of repeat I; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACAAGCCAGGCGAGGAAGAAA	0.458													0	0	0	0.010729	0	10	38										T	101944589	C	T	101944589	3	4	27	1	0	0	0	0	1	0	0	0	10148	768	27	2	4436	2	NALCN	13	101944589	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	60033745	101944589	13225289	244	7497										
C13orf27	93081	broad.mit.edu	37	chr13	103419691	103419691	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttttaaacgaaagaggtcttCatctctgagtttatgctgct	8	7	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr13:103419691C>A	uc001vpo.2	-	5	614	c.436G>T	c.(436-438)GAA>TAA	p.E146*	C13orf27_uc001vpn.2_Nonsense_Mutation_p.E105*|C13orf27_uc001vpp.2_Nonsense_Mutation_p.E105*	NM_138779	NP_620134	Q5JUR7	CM027_HUMAN	hypothetical protein LOC93081	146											0	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAGAGGTCTTCATCTCTGAGT	0.408													1	0	0.00307968	0.00308	0.00317789	6	155										A	103419691	C	A	103419691	4	1	27	1	0	0	0	0	0	1	0	0	1723	835	29	3	255	3	C13orf27	13	103419691	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1475102	103419691	11750187	245	7498										
SALL2	6297	broad.mit.edu	37	chr14	21993519	21993519	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agactcctctcctctcctctCtgggccccaggtgggatccg	10	17	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:21993519C>T	uc001wbe.2	-	2	625	c.343G>A	c.(343-345)GAG>AAG	p.E115K	SALL2_uc010tly.1_Missense_Mutation_p.E113K|SALL2_uc010tlz.1_Missense_Mutation_p.E113K|SALL2_uc001wbf.3_Missense_Mutation_p.E113K|SALL2_uc010tma.1_Missense_Mutation_p.E115K|SALL2_uc001wbg.1_Missense_Mutation_p.E115K	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	115							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CCTCTCCTCTCTGGGCCCCAG	0.642													0	0	0	0.000602	0	5	74										T	21993519	C	T	21993519	3	4	27	1	0	0	0	0	1	0	0	0	13811	922	32	1	2684	1	SALL2	14	21993519	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		21993519	85356021	246	7499										
PRKD1	5587	broad.mit.edu	37	chr14	30105594	30105594	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccatctctgcatcttggacCattgcttcttccatatcatc	5	14	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:30105594C>A	uc001wqh.2	-	7	1273	c.1092G>T	c.(1090-1092)ATG>ATT	p.M364I		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	364					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		CATCTTGGACCATTGCTTCTT	0.517													1	0	8.00594e-06	0.007413	8.47358e-06	17	151										A	30105594	C	A	30105594	3	1	27	1	0	0	0	0	1	0	0	0	12518	594	21	4	1694	4	PRKD1	14	30105594	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	8112075	30105594	77243946	247	7500										
ARHGAP5	394	broad.mit.edu	37	chr14	32560932	32560932	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttaacactcttttgccaaatCtagaagagattgaacatttg	6	7	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:32560932C>G	uc001wrl.2	+	2	1296	c.1057C>G	c.(1057-1059)CTA>GTA	p.L353V	ARHGAP5_uc001wrm.2_Missense_Mutation_p.L353V|ARHGAP5_uc001wrn.2_Missense_Mutation_p.L353V|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	353					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTTGCCAAATCTAGAAGAGAT	0.323													0	0	0	0.00499	0	18	173										G	32560932	C	G	32560932	3	3	27	1	0	0	0	0	1	0	0	0	886	912	32	1	1059	1	ARHGAP5	14	32560932	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2455338	32560932	74788608	248	7501										
BAZ1A	11177	broad.mit.edu	37	chr14	35228028	35228028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctgtcggccagaactccttCgacccagtgtcacaggcgat	10	15	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:35228028C>T	uc001wsk.2	-	25	4836	c.4268G>A	c.(4267-4269)CGA>CAA	p.R1423Q	BAZ1A_uc001wsl.2_Missense_Mutation_p.R1391Q	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1423					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding	p.R1423fs*21(1)		lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		AGAACTCCTTCGACCCAGTGT	0.408													0	0	0	0.001984	0	7	73										T	35228028	C	T	35228028	3	4	27	1	0	0	0	0	1	0	0	0	1329	884	31	1	414	1	BAZ1A	14	35228028	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2667096	35228028	72121512	249	7502										
RALGAPA1	253959	broad.mit.edu	37	chr14	36230213	36230213	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgaacaccttcccgcctaatCtaaaataaaatgaaaataga	4	10	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:36230213C>A	uc001wti.2	-	6	761	c.370_splice	c.e6-1	p.I124_splice	RALGAPA1_uc001wtj.2_Splice_Site_p.I124_splice|RALGAPA1_uc010tpv.1_Splice_Site_p.I124_splice|RALGAPA1_uc010tpw.1_Splice_Site_p.I124_splice|RALGAPA1_uc001wtk.1_Splice_Site	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1						activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CCCGCCTAATCTAAAATAAAA	0.323													1	0	0.000602214	0.000602	0.000624263	5	35										A	36230213	C	A	36230213	5	1	27	1	0	0	0	0	0	0	1	0	13013	927	32	3	6034	3	RALGAPA1	14	36230213	Splice_Site	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1002185	36230213	71119327	250	7503										
KLHDC2	23588	broad.mit.edu	37	chr14	50246473	50246473	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tatccttttttaggatgctaGaatgaatgatcttcactatc	6	7	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:50246473G>C	uc001wwx.2	+	8	1122	c.722G>C	c.(721-723)AGA>ACA	p.R241T	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Missense_Mutation_p.R241T|KLHDC2_uc010anp.2_Missense_Mutation_p.R241T	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	241	Kelch 4.					nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)					TAGGATGCTAGAATGAATGAT	0.318													0	0	0	0.006214	0	10	89										C	50246473	G	C	50246473	3	2	27	1	0	0	0	0	1	0	0	0	8356	942	33	1	752	1	KLHDC2	14	50246473	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	14016260	50246473	57103067	251	7504										
C14orf138	79609	broad.mit.edu	37	chr14	50583166	50583166	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acaacgcaacccacgccaccGgagctatactgctgtagtcg	9	15	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:50583166G>A	uc001wxo.1	-	1	132	c.105C>T	c.(103-105)TCC>TCT	p.S35S	C14orf138_uc001wxn.1_5'Flank|C14orf138_uc001wxp.1_Silent_p.S35S|C14orf138_uc001wxq.1_RNA	NM_024558	NP_078834	Q9H867	MT21D_HUMAN	hypothetical protein LOC79609 isoform a	35							methyltransferase activity				0	all_epithelial(31;0.000822)|Breast(41;0.0065)					CCACGCCACCGGAGCTATACT	0.602													0	0	0	0.000602	0	5	18										A	50583166	G	A	50583166	2	1	27	1	0	0	0	0	0	0	0	1	1746	1103	39	2		2	C14orf138	14	50583166	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	336693	50583166	56766374	252	7505										
WDHD1	11169	broad.mit.edu	37	chr14	55448271	55448271	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agcccaccttagttgctgggGattttcatggataccaacca	9	11	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:55448271G>A	uc001xbm.1	-	16	2128	c.2050C>T	c.(2050-2052)CCC>TCC	p.P684S	WDHD1_uc010aom.1_Missense_Mutation_p.P201S|WDHD1_uc001xbn.1_Missense_Mutation_p.P561S	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	684						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						AGTTGCTGGGGATTTTCATGG	0.368													0	0	0	0.013537	0	11	114										A	55448271	G	A	55448271	3	1	27	1	0	0	0	0	1	0	0	0	17268	1174	41	1	1383	1	WDHD1	14	55448271	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4865105	55448271	51901269	253	7506										
WDHD1	11169	broad.mit.edu	37	chr14	55467688	55467688	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctaaatattgcccacagggaGaccaggttactatattgagg	10	8	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:55467688G>A	uc001xbm.1	-	9	794	c.716C>T	c.(715-717)TCT>TTT	p.S239F	WDHD1_uc001xbn.1_Missense_Mutation_p.S116F	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	239	WD 6.					cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CCCACAGGGAGACCAGGTTAC	0.308													0	0	0	0.008871	0	21	166										A	55467688	G	A	55467688	3	1	27	1	0	0	0	0	1	0	0	0	17268	942	33	1	2745	1	WDHD1	14	55467688	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	19417	55467688	51881852	254	7507										
SPTB	6710	broad.mit.edu	37	chr14	65234536	65234536	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgggcaatcagccacgcctCagccacagaggcatccctcg	10	17	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:65234536C>G	uc001xht.2	-	29	6118	c.6064G>C	c.(6064-6066)GAG>CAG	p.E2022Q	SPTB_uc001xhr.2_Missense_Mutation_p.E2022Q|SPTB_uc001xhs.2_Missense_Mutation_p.E2022Q|SPTB_uc001xhu.2_Missense_Mutation_p.E2022Q|SPTB_uc010aqi.2_Missense_Mutation_p.E683Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2022	Spectrin 17.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGCCACGCCTCAGCCACAGAG	0.607													0	0	0	0.004482	0	8	29										G	65234536	C	G	65234536	3	3	27	1	0	0	0	0	1	0	0	0	15117	835	29	1	1019	1	SPTB	14	65234536	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9766848	65234536	42115004	255	7508										
RGS6	9628	broad.mit.edu	37	chr14	72985157	72985157	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtttctggctccaggggctcCaagtgcaatcaacctggatt	11	11	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:72985157C>G	uc001xna.3	+	15	1713	c.1190C>G	c.(1189-1191)CCA>CGA	p.P397R	RGS6_uc010ttn.1_Missense_Mutation_p.P397R|RGS6_uc001xmx.3_Missense_Mutation_p.P397R|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.P397R|RGS6_uc010ttp.1_Missense_Mutation_p.P328R|RGS6_uc001xmz.1_Missense_Mutation_p.P258R	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	397	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CCAGGGGCTCCAAGTGCAATC	0.468													0	0	0	0.008291	0	9	59										G	72985157	C	G	72985157	3	3	27	1	0	0	0	0	1	0	0	0	13309	594	21	4	1244	4	RGS6	14	72985157	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	7750621	72985157	34364383	256	7509										
ZNF410	57862	broad.mit.edu	37	chr14	74360609	74360609	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccttcccgtgactgaagcctCagaatgcagtcggctaatgt	10	12	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:74360609C>A	uc001xoz.1	+	3	325	c.143C>A	c.(142-144)TCA>TAA	p.S48*	ZNF410_uc001xoy.1_RNA|ZNF410_uc010ary.1_RNA|ZNF410_uc010tuf.1_RNA|ZNF410_uc010tug.1_5'UTR|ZNF410_uc010tuh.1_Nonsense_Mutation_p.S48*|ZNF410_uc010tui.1_RNA|ZNF410_uc010arz.1_Nonsense_Mutation_p.S48*|ZNF410_uc001xpa.1_5'UTR|ZNF410_uc001xpb.1_Nonsense_Mutation_p.S48*|ZNF410_uc001xpc.1_5'UTR	NM_021188	NP_067011	Q86VK4	ZN410_HUMAN	zinc finger protein 410	48					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00369)		ACTGAAGCCTCAGAATGCAGT	0.418													1	0	1.1362e-29	0.01441	1.24624e-29	62	103										A	74360609	C	A	74360609	4	1	27	1	0	0	0	0	0	1	0	0	17887	838	29	3	149	3	ZNF410	14	74360609	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1375452	74360609	32988931	257	7510										
RIN3	79890	broad.mit.edu	37	chr14	93081784	93081784	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaggctcggctcttgtgtttGaggacatcttcagattgatt	11	7	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr14:93081784G>C	uc001yap.2	+	4	552	c.400G>C	c.(400-402)GAG>CAG	p.E134Q	RIN3_uc010auk.2_Intron|RIN3_uc001yaq.2_Missense_Mutation_p.E59Q	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	134	SH2.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				TCTTGTGTTTGAGGACATCTT	0.522													0	0	0	0.001855	0	11	189										C	93081784	G	C	93081784	3	2	27	1	0	0	0	0	1	0	0	0	13373	1291	45	1	414	1	RIN3	14	93081784	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	18721175	93081784	14267756	258	7511										
MAGEL2	54551	broad.mit.edu	37	chr15	23889947	23889947	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gagctccctgggctttcagaGagacccagggccctggaggt	15	12	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:23889947G>C	uc001ywj.3	-	1	1229	c.1134C>G	c.(1132-1134)CTC>CTG	p.L378L		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		GGCTTTCAGAGAGACCCAGGG	0.647													0	0	0	0.009096	0	4	20										C	23889947	G	C	23889947	2	2	27	1	0	0	0	0	0	0	0	1	9189	929	33	1		1	MAGEL2	15	23889947	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08		23889947	78641445	259	7512										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32917399	32917399	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagaaaagaagctacgattaCaggctgcagtagtacagact	10	8	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:32917399C>A	uc001zgy.1	+	5	1392	c.670C>A	c.(670-672)CAG>AAG	p.Q224K	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.Q35K|ARHGAP11A_uc001zgw.2_Missense_Mutation_p.Q224K|ARHGAP11A_uc001zgx.2_Missense_Mutation_p.Q224K|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.Q35K	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	224	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		GCTACGATTACAGGCTGCAGT	0.363													1	0	5.82388e-19	0.01441	6.32666e-19	53	68										A	32917399	C	A	32917399	3	1	27	1	0	0	0	0	1	0	0	0	863	479	17	4	688	4	ARHGAP11A	15	32917399	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9027452	32917399	69613993	260	7513										
FMN1	342184	broad.mit.edu	37	chr15	33359049	33359049	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgtcaatgttgagcagcagaGagagctgctccaggagagtg	15	7	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:33359049G>C	uc001zhf.3	-	1	1037	c.1037C>G	c.(1036-1038)TCT>TGT	p.S346C	FMN1_uc001zhg.2_Missense_Mutation_p.S346C	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GAGCAGCAGAGAGAGCTGCTC	0.557													0	0	0	0.010729	0	10	98										C	33359049	G	C	33359049	3	2	27	1	0	0	0	0	1	0	0	0	5949	942	33	1	2621	1	FMN1	15	33359049	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	441650	33359049	69172343	261	7514										
C15orf55	256646	broad.mit.edu	37	chr15	34649515	34649515	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cctgttgccaagtctgggaaGcgagctctagctggaggtcc	14	11	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:34649515G>A	uc001zif.2	+	7	3377	c.3222G>A	c.(3220-3222)AAG>AAA	p.K1074K	C15orf55_uc010ucc.1_Silent_p.K1102K|C15orf55_uc010ucd.1_Silent_p.K1092K	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	1074						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGTCTGGGAAGCGAGCTCTAG	0.587			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.009096	0	4	55										A	34649515	G	A	34649515	2	1	27	1	0	0	0	0	0	0	0	1	1803	962	34	2		2	C15orf55	15	34649515	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1290466	34649515	67881877	262	7515										
SPRED1	161742	broad.mit.edu	37	chr15	38591726	38591726	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgctgacttttttatccgtgGagagcgactcagggacaaaa	11	8	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:38591726G>A	uc001zka.3	+	2	520	c.185G>A	c.(184-186)GGA>GAA	p.G62E		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	62	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TTTATCCGTGGAGAGCGACTC	0.388									Legius_syndrome				0	0	0	0.001984	0	7	94										A	38591726	G	A	38591726	3	1	27	1	0	0	0	0	1	0	0	0	15091	1174	41	1	191	1	SPRED1	15	38591726	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3942211	38591726	63939666	263	7516										
RASGRP1	10125	broad.mit.edu	37	chr15	38808463	38808463	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggatagctcttctggttccaGatggtcaaagagcagggaga	14	7	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:38808463G>C	uc001zke.3	-	6	788	c.610C>G	c.(610-612)CTG>GTG	p.L204V	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Missense_Mutation_p.L66V|RASGRP1_uc010bbg.2_Missense_Mutation_p.L66V|RASGRP1_uc001zkd.3_Missense_Mutation_p.L204V	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	204					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TCTGGTTCCAGATGGTCAAAG	0.468													0	0	0	0.009096	0	4	98										C	38808463	G	C	38808463	3	2	27	1	0	0	0	0	1	0	0	0	13074	933	33	1	1831	1	RASGRP1	15	38808463	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	216737	38808463	63722929	264	7517										
NUSAP1	51203	broad.mit.edu	37	chr15	41625174	41625174	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgatgatcatcccctctctaGaggagctggactccctcaag	9	14	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:41625174G>C	uc001zns.3	+	1	249	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	OIP5_uc001znp.2_5'Flank|NUSAP1_uc001znq.3_5'UTR|NUSAP1_uc001znr.3_Missense_Mutation_p.E7Q|NUSAP1_uc010bce.2_Missense_Mutation_p.E7Q|NUSAP1_uc001znt.3_Missense_Mutation_p.E7Q|NUSAP1_uc001znv.3_Missense_Mutation_p.E7Q|NUSAP1_uc001znu.3_Missense_Mutation_p.E7Q|NUSAP1_uc010ucw.1_Missense_Mutation_p.E7Q	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	7					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		CCCCTCTCTAGAGGAGCTGGA	0.582													0	0	0	0.001984	0	6	21										C	41625174	G	C	41625174	3	2	27	1	0	0	0	0	1	0	0	0	10778	943	33	1	21	1	NUSAP1	15	41625174	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2816711	41625174	60906218	265	7518										
LTK	4058	broad.mit.edu	37	chr15	41805071	41805071	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agaaaacagccaagacccctCggtgcctgagagcaaggagc	12	12	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:41805071C>G	uc001zoa.3	-	3	371	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	LTK_uc001zob.3_Missense_Mutation_p.E65Q|LTK_uc010ucx.1_Missense_Mutation_p.E65Q|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	65	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CAAGACCCCTCGGTGCCTGAG	0.652										TSP Lung(18;0.14)			0	0	0	0.009096	0	3	44										G	41805071	C	G	41805071	3	3	27	1	0	0	0	0	1	0	0	0	9080	893	31	1	2473	1	LTK	15	41805071	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	179897	41805071	60726321	266	7519										
MGA	23269	broad.mit.edu	37	chr15	41961828	41961828	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atcagaacattcagattactCagctgaaaatagattacaat	5	7	3	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:41961828C>G	uc001zog.1	+	2	827	c.736C>G	c.(736-738)CAG>GAG	p.Q246E	MGA_uc010ucy.1_Missense_Mutation_p.Q246E|MGA_uc010ucz.1_Missense_Mutation_p.Q246E	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	246	T-box.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCAGATTACTCAGCTGAAAAT	0.418													0	0	0	0.007291	0	30	32										G	41961828	C	G	41961828	3	3	27	1	0	0	0	0	1	0	0	0	9540	827	29	1	738	1	MGA	15	41961828	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	156757	41961828	60569564	267	7520										
CDAN1	146059	broad.mit.edu	37	chr15	43025297	43025297	+	Silent	SNP	G	G	A													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	caaggtctgagcacccacctGattctgctgcccaagccctt							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:43025297G>A	uc001zql.2	-	9	1572	c.1455C>T	c.(1453-1455)ATC>ATT	p.I485I	CDAN1_uc001zqj.2_5'Flank|CDAN1_uc001zqk.2_5'UTR|CDAN1_uc010bcx.1_RNA	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	485						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GCACCCACCTGATTCTGCTGC	0.552													0	0	0	0.00308	0	8	74										A	43025297	G	A	43025297	2	1	27	1	0	0	0	0	0	0	0	1	3054	1280	45	1		1	CDAN1	15	43025297	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1063469	43025297	59506095	268	7521	34	2								
CDAN1	146059	broad.mit.edu	37	chr15	43025301	43025301	+	Missense_Mutation	SNP	C	C	T													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtctgagcacccacctgattCtgctgcccaagcccttctca							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:43025301C>T	uc001zql.2	-	9	1568	c.1451G>A	c.(1450-1452)AGA>AAA	p.R484K	CDAN1_uc001zqj.2_5'Flank|CDAN1_uc001zqk.2_5'UTR|CDAN1_uc010bcx.1_RNA	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	484						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CCACCTGATTCTGCTGCCCAA	0.552													0	0	0	0.00308	0	8	76										T	43025301	C	T	43025301	3	4	27	1	0	0	0	0	1	0	0	0	3054	913	32	1	2312	1	CDAN1	15	43025301	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4	43025301	59506091	269	7522	34	2								
CASC4	113201	broad.mit.edu	37	chr15	44695105	44695105	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccgattctttgatgaaaatGaatcccctgttgatccgcag	9	10	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:44695105G>C	uc001zto.1	+	9	1392	c.1093G>C	c.(1093-1095)GAA>CAA	p.E365Q	CASC4_uc001ztp.2_Missense_Mutation_p.E365Q|CASC4_uc001ztq.2_Intron	NM_138423	NP_612432	Q6P4E1	CASC4_HUMAN	cancer susceptibility candidate 4 isoform a	365	Lumenal (Potential).					integral to membrane				ovary(1)	1		all_cancers(109;1.69e-13)|all_epithelial(112;3.94e-11)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.027)		all cancers(107;2.91e-20)|GBM - Glioblastoma multiforme(94;1.57e-06)|COAD - Colon adenocarcinoma(120;0.217)|Colorectal(105;0.237)		TGATGAAAATGAATCCCCTGT	0.453													0	0	0	0.004482	0	8	75										C	44695105	G	C	44695105	3	2	27	1	0	0	0	0	1	0	0	0	2662	1291	45	1	1127	1	CASC4	15	44695105	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1669804	44695105	57836287	270	7523										
SCG3	29106	broad.mit.edu	37	chr15	51988109	51988109	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaagaaacactgattactatCatgaaaacactgattgactt	5	7	1	5			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:51988109C>G	uc002abh.2	+	8	1314	c.906C>G	c.(904-906)ATC>ATG	p.I302M	SCG3_uc010ufz.1_Missense_Mutation_p.I70M	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	302					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		TGATTACTATCATGAAAACAC	0.333													0	0	0	0.01441	0	72	110										G	51988109	C	G	51988109	3	3	27	1	0	0	0	0	1	0	0	0	13892	816	29	1	936	1	SCG3	15	51988109	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	7293004	51988109	50543283	271	7524										
C15orf44	81556	broad.mit.edu	37	chr15	65891286	65891286	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cccttcaccattgtttaaatCtatgagacgttcaaggcatt	6	10	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:65891286C>G	uc002apd.2	-	5	865	c.529G>C	c.(529-531)GAT>CAT	p.D177H	C15orf44_uc010uix.1_Missense_Mutation_p.D213H|C15orf44_uc010uiz.1_Missense_Mutation_p.D141H|C15orf44_uc010uja.1_Missense_Mutation_p.D128H|C15orf44_uc010ujb.1_Missense_Mutation_p.D98H|C15orf44_uc002ape.3_Missense_Mutation_p.D177H|C15orf44_uc010uiy.1_Missense_Mutation_p.D98H	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	177	VWFA.			D -> Y (in Ref. 2; BAB55140).						ovary(1)	1						TTGTTTAAATCTATGAGACGT	0.418													0	0	0	0.013537	0	11	123										G	65891286	C	G	65891286	3	3	27	1	0	0	0	0	1	0	0	0	1798	913	32	1	1059	1	C15orf44	15	65891286	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	13903177	65891286	36640106	272	7525										
DENND4A	10260	broad.mit.edu	37	chr15	65983838	65983838	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agatgatattaagagcagctCaggtgtgctttctgaaaaac	10	6	2	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:65983838C>T	uc002aph.2	-	22	3340	c.2962G>A	c.(2962-2964)GAG>AAG	p.E988K	DENND4A_uc002api.2_Missense_Mutation_p.E1031K|DENND4A_uc002apj.3_Missense_Mutation_p.E988K	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	988					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AAGAGCAGCTCAGGTGTGCTT	0.284													0	0	0	0.003163	0	16	8										T	65983838	C	T	65983838	3	4	27	1	0	0	0	0	1	0	0	0	4433	835	29	1	2673	1	DENND4A	15	65983838	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	92552	65983838	36547554	273	7526										
CLK3	1198	broad.mit.edu	37	chr15	74912488	74912488	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	catcgtcggcgatcgcgggaGagggggccataccggacccg	17	13	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:74912488G>A	uc010uln.1	+	3	1196	c.735G>A	c.(733-735)GAG>GAA	p.E245E	CLK3_uc002ayg.3_Silent_p.E97E|CLK3_uc002ayh.3_5'UTR|CLK3_uc010ulm.1_Silent_p.E245E|CLK3_uc002ayj.3_Silent_p.E97E|CLK3_uc002ayk.3_5'UTR	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	245	Arg-rich.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						GATCGCGGGAGAGGGGGCCAT	0.617													0	0	0	0.01441	0	51	75										A	74912488	G	A	74912488	2	1	27	1	0	0	0	0	0	0	0	1	3538	933	33	1		1	CLK3	15	74912488	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8928650	74912488	27618904	274	7527										
POLG	5428	broad.mit.edu	37	chr15	89873444	89873444	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccagggggatgaggtcagcCggcgacagctggctggtcca	17	11	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:89873444C>T	uc002bns.3	-	3	1005	c.723G>A	c.(721-723)CCG>CCA	p.P241P	POLG_uc002bnr.3_Silent_p.P241P	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	241					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			TGAGGTCAGCCGGCGACAGCT	0.617								DNA_polymerases_(catalytic_subunits)					0	0	0	0.006214	0	10	47										T	89873444	C	T	89873444	2	4	27	1	0	0	0	0	0	0	0	1	12200	639	23	2		2	POLG	15	89873444	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	14960956	89873444	12657948	275	7528										
TTC23	64927	broad.mit.edu	37	chr15	99759146	99759146	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcccatggtatggaaaagctCaatggaaaacttgaaaacat	9	7	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr15:99759146C>G	uc002bur.2	-	6	943	c.412G>C	c.(412-414)GAG>CAG	p.E138Q	TTC23_uc002bus.2_Missense_Mutation_p.E138Q|TTC23_uc002but.2_Missense_Mutation_p.E138Q|TTC23_uc002buu.2_Missense_Mutation_p.E138Q|TTC23_uc002buv.2_Missense_Mutation_p.E138Q|TTC23_uc002bux.2_Missense_Mutation_p.E138Q|TTC23_uc002buw.2_Missense_Mutation_p.E138Q|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Missense_Mutation_p.E138Q|TTC23_uc010bor.2_Missense_Mutation_p.E138Q|TTC23_uc002buz.2_Missense_Mutation_p.E138Q	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	138	TPR 2.						binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			TGGAAAAGCTCAATGGAAAAC	0.393													0	0	0	0.007413	0	19	216										G	99759146	C	G	99759146	3	3	27	1	0	0	0	0	1	0	0	0	16687	835	29	1	963	1	TTC23	15	99759146	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9885702	99759146	2772246	276	7529										
BAIAP3	8938	broad.mit.edu	37	chr16	1391337	1391337	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctgggcatcctgcctgcctCggacgccacgcgggagcccc	14	18	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:1391337C>T	uc002clk.1	+	8	683	c.683C>T	c.(682-684)TCG>TTG	p.S228L	BAIAP3_uc002clj.2_Missense_Mutation_p.S210L|BAIAP3_uc010uuz.1_Missense_Mutation_p.S193L|BAIAP3_uc010uva.1_Missense_Mutation_p.S165L|BAIAP3_uc010uvb.1_Missense_Mutation_p.S245L|BAIAP3_uc010uvc.1_Missense_Mutation_p.S193L	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	228	C2 1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				CTGCCTGCCTCGGACGCCACG	0.706													0	0	0	0.008291	0	9	29										T	1391337	C	T	1391337	3	4	27	1	0	0	0	0	1	0	0	0	1304	893	31	1	713	1	BAIAP3	16	1391337	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		1391337	88963416	277	7530										
AMDHD2	51005	broad.mit.edu	37	chr16	2570828	2570828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagagaagctgttctttgagGagcggcgcgtggccgacgag	17	9	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:2570828G>A	uc002cqq.2	+	2	239	c.142G>A	c.(142-144)GAG>AAG	p.E48K	AMDHD2_uc002cqp.2_Missense_Mutation_p.E48K|AMDHD2_uc010uwc.1_Missense_Mutation_p.E48K|AMDHD2_uc010uwd.1_Intron	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	48					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						GTTCTTTGAGGAGCGGCGCGT	0.711													0	0	0	0.001855	0	6	13										A	2570828	G	A	2570828	3	1	27	1	0	0	0	0	1	0	0	0	568	1175	41	1	148	1	AMDHD2	16	2570828	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1179491	2570828	87783925	278	7531										
ADCY9	115	broad.mit.edu	37	chr16	4016190	4016190	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagtcatagcccatcttgctCaagacgcggtagctctcttc	8	13	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:4016190C>G	uc002cvx.2	-	11	4187	c.3648G>C	c.(3646-3648)TTG>TTC	p.L1216F		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1216	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CCATCTTGCTCAAGACGCGGT	0.572													0	0	0	0.010729	0	10	140										G	4016190	C	G	4016190	3	3	27	1	0	0	0	0	1	0	0	0	301	825	29	1	417	1	ADCY9	16	4016190	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1445362	4016190	86338563	279	7532										
PALB2	79728	broad.mit.edu	37	chr16	23640969	23640969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aatggattgtacctgttcgaCggaatgtttatgcagctcct	10	8	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:23640969C>T	uc002dlx.1	-	5	2706	c.2506G>A	c.(2506-2508)GTC>ATC	p.V836I		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	836					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		ACCTGTTCGACGGAATGTTTA	0.443			F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.001855	0	14	74										T	23640969	C	T	23640969	3	4	27	1	0	0	0	0	1	0	0	0	11406	536	19	2	1090	2	PALB2	16	23640969	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	19624779	23640969	66713784	280	7533										
SH2B1	25970	broad.mit.edu	37	chr16	28878108	28878108	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	actcaccgttttgagaggctGagactcagtcggggaggggg	17	8	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:28878108G>A	uc002dri.2	+	4	1132	c.693G>A	c.(691-693)CTG>CTA	p.L231L	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Silent_p.L231L|SH2B1_uc002drk.2_Silent_p.L231L|SH2B1_uc002drl.2_Silent_p.L231L|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Silent_p.L231L|SH2B1_uc002drm.2_Silent_p.L231L	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	231	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Required for NGF signaling (By similarity).|Required for nuclear localization (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						TTGAGAGGCTGAGACTCAGTC	0.622													0	0	0	0.008291	0	11	29										A	28878108	G	A	28878108	2	1	27	1	0	0	0	0	0	0	0	1	14227	1277	45	1		1	SH2B1	16	28878108	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5237139	28878108	61476645	281	7534										
ABCC11	85320	broad.mit.edu	37	chr16	48264436	48264436	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgccctccctggagcctcagGatttctctcttgctgactcc	8	16	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:48264436G>C	uc002eff.1	-	2	498	c.148C>G	c.(148-150)CCT>GCT	p.P50A	ABCC11_uc002efg.1_Missense_Mutation_p.P50A|ABCC11_uc002efh.1_Missense_Mutation_p.P50A|ABCC11_uc010vgl.1_Missense_Mutation_p.P50A	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	50	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGAGCCTCAGGATTTCTCTCT	0.498									Cerumen_Type				0	0	0	0.001984	0	4	44										C	48264436	G	C	48264436	3	2	27	1	0	0	0	0	1	0	0	0	51	1174	41	1	4112	1	ABCC11	16	48264436	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	19386328	48264436	42090317	282	7535										
ZNF423	23090	broad.mit.edu	37	chr16	49671947	49671947	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccacagaggcgctggagtcGggtgtggcgctgctcatgga	17	10	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:49671947G>A	uc002efs.2	-	5	1414	c.1116C>T	c.(1114-1116)CCC>CCT	p.P372P	ZNF423_uc010vgn.1_Silent_p.P255P	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	372					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CGCTGGAGTCGGGTGTGGCGC	0.677													0	0	0	0.000602	0	5	21										A	49671947	G	A	49671947	2	1	27	1	0	0	0	0	0	0	0	1	17895	1103	39	2		2	ZNF423	16	49671947	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1407511	49671947	40682806	283	7536										
HEATR3	55027	broad.mit.edu	37	chr16	50100305	50100305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acccgagcgccgaggtccgcGagtgcgcctgcgcagggctg	17	15	0	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:50100305G>A	uc002efw.2	+	2	328	c.166G>A	c.(166-168)GAG>AAG	p.E56K	HEATR3_uc002efx.2_Intron	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	56	HEAT 1.						binding			ovary(1)|skin(1)	2						CGAGGTCCGCGAGTGCGCCTG	0.756													0	0	0	0.009096	0	3	5										A	50100305	G	A	50100305	3	1	27	1	0	0	0	0	1	0	0	0	7029	1059	37	1	172	1	HEATR3	16	50100305	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	428358	50100305	40254448	284	7537										
NLRC5	84166	broad.mit.edu	37	chr16	57065331	57065331	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgcagggaggcggacctcatCttccttctttccccgcccac	9	17	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:57065331C>T	uc002ekk.1	+	11	2658	c.2433C>T	c.(2431-2433)ATC>ATT	p.I811I	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Silent_p.I560I|NLRC5_uc002ekl.2_Silent_p.I616I|NLRC5_uc002ekm.2_Silent_p.I616I|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_5'Flank	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	811					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CGGACCTCATCTTCCTTCTTT	0.562													0	0	0	0.009096	0	4	48										T	57065331	C	T	57065331	2	4	27	1	0	0	0	0	0	0	0	1	10470	903	32	1		1	NLRC5	16	57065331	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6965026	57065331	33289422	285	7538										
EDC4	23644	broad.mit.edu	37	chr16	67909846	67909846	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaatgaccctctttgtccccAggccccagtgcagagagccc	10	16	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:67909846A>T	uc002eur.2	+	2	249	c.83_splice	c.e2-2	p.G28_splice	EDC4_uc010cer.2_Splice_Site|EDC4_uc010vkg.1_Splice_Site|EDC4_uc010ces.1_5'Flank|EDC4_uc002eus.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTTTGTCCCCAGGCCCCAGTG	0.557													0	0	0	0.011902	0	46	120										T	67909846	A	T	67909846	5	4	27	1	0	0	0	0	0	0	1	0	4908	202	7	5	87	5	EDC4	16	67909846	Splice_Site	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	10844515	67909846	22444907	286	7539										
VAT1L	57687	broad.mit.edu	37	chr16	77859262	77859262	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttctccgaggctgctgcattCcccatgaacttcgtcacagc	8	15	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:77859262C>T	uc002ffg.1	+	3	580	c.483C>T	c.(481-483)TTC>TTT	p.F161F		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	161							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						CTGCTGCATTCCCCATGAACT	0.537													0	0	0	0.009096	0	4	39										T	77859262	C	T	77859262	2	4	27	1	0	0	0	0	0	0	0	1	17127	854	30	1		1	VAT1L	16	77859262	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9949416	77859262	12495491	287	7540										
PKD1L2	114780	broad.mit.edu	37	chr16	81249935	81249935	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcccgatgtggccgcaggtGtcaggggcagcggcggcctg	18	13	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:81249935G>A	uc002fgh.1	-	2	378	c.378C>T	c.(376-378)GAC>GAT	p.D126D	PKD1L2_uc002fgj.2_Silent_p.D126D	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	126	Extracellular (Potential).|C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCCGCAGGTGTCAGGGGCAG	0.657													0	0	0	0.00333	0	14	37										A	81249935	G	A	81249935	2	1	27	1	0	0	0	0	0	0	0	1	11965	1368	48	2		2	PKD1L2	16	81249935	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3390673	81249935	9104818	288	7541										
CDH15	1013	broad.mit.edu	37	chr16	89254631	89254631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccatcctggaaggcgaccccGatgggcagttcaccatccgc	11	16	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr16:89254631G>A	uc002fmt.2	+	7	993	c.916G>A	c.(916-918)GAT>AAT	p.D306N		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	306	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		AGGCGACCCCGATGGGCAGTT	0.647													0	0	0	0.004672	0	3	21										A	89254631	G	A	89254631	3	1	27	1	0	0	0	0	1	0	0	0	3100	1058	37	1	942	1	CDH15	16	89254631	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8004696	89254631	1100122	289	7542										
PRPF8	10594	broad.mit.edu	37	chr17	1582371	1582371	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tagtccaggtgcaggtagttGaggtttttgcggtgaatgag	16	4	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:1582371G>A	uc002fte.2	-	11	1653	c.1539C>T	c.(1537-1539)CTC>CTT	p.L513L		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	513						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GCAGGTAGTTGAGGTTTTTGC	0.542													0	0	0	0.00632	0	26	83										A	1582371	G	A	1582371	2	1	27	1	0	0	0	0	0	0	0	1	12575	1277	45	1		1	PRPF8	17	1582371	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08		1582371	79612839	290	7543										
MYH2	4620	broad.mit.edu	37	chr17	10432249	10432249	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcccgcttcttgttcatctCaatctgggctgaagtggccc	9	14	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:10432249C>T	uc010coi.2	-	27	3630	c.3502G>A	c.(3502-3504)GAG>AAG	p.E1168K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.E1168K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1168	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTGTTCATCTCAATCTGGGCT	0.612													0	0	0	0.001855	0	10	106										T	10432249	C	T	10432249	3	4	27	1	0	0	0	0	1	0	0	0	10035	835	29	1	2379	1	MYH2	17	10432249	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	8849878	10432249	70762961	291	7544										
MYH3	4621	broad.mit.edu	37	chr17	10535904	10535904	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccccctccatcttcttcttGagccggatggcttcattcct	6	16	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:10535904G>C	uc002gmq.1	-	33	4922	c.4845C>G	c.(4843-4845)CTC>CTG	p.L1615L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1615	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity	p.L1615R(1)		ovary(4)|central_nervous_system(2)|pancreas(1)	7						TCTTCTTCTTGAGCCGGATGG	0.587													0	0	0	0.00308	0	6	325										C	10535904	G	C	10535904	2	2	27	1	0	0	0	0	0	0	0	1	10036	1277	45	1		1	MYH3	17	10535904	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	103655	10535904	70659306	292	7545										
RAI1	10743	broad.mit.edu	37	chr17	17699982	17699982	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	accaagaagcggaacctggtCttgcggagccgcagcagcag	14	12	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17699982C>G	uc002grm.2	+	3	4189	c.3720C>G	c.(3718-3720)GTC>GTG	p.V1240V	RAI1_uc002grn.1_Silent_p.V1240V	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1240	Nuclear localization signal (Potential).					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GGAACCTGGTCTTGCGGAGCC	0.632													0	0	0	0.000602	0	5	20										G	17699982	C	G	17699982	2	3	27	1	0	0	0	0	0	0	0	1	13007	900	32	1		1	RAI1	17	17699982	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	7164078	17699982	63495228	293	7546			2	24		7	6	1387	N	C	1.07409e-11
RAI1	10743	broad.mit.edu	37	chr17	17700179	17700179	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgcctgcctcaagctcgcctCtcgggcagccttccaggggg	13	16	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17700179C>G	uc002grm.2	+	3	4386	c.3917C>G	c.(3916-3918)TCT>TGT	p.S1306C	RAI1_uc002grn.1_Missense_Mutation_p.S1306C	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1306						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		AAGCTCGCCTCTCGGGCAGCC	0.652													0	0	0	0.004007	0	16	77										G	17700179	C	G	17700179	3	3	27	1	0	0	0	0	1	0	0	0	13007	913	32	1	3919	1	RAI1	17	17700179	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	197	17700179	63495031	294	7547			2	24		7	6	1387	N	C	1.07409e-11
RAI1	10743	broad.mit.edu	37	chr17	17700285	17700285	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagatcacctcgcccagcctCaagaagttcgcatgtaaagc	8	13	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17700285C>G	uc002grm.2	+	3	4492	c.4023C>G	c.(4021-4023)CTC>CTG	p.L1341L	RAI1_uc002grn.1_Silent_p.L1341L	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1341						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CGCCCAGCCTCAAGAAGTTCG	0.632													0	0	0	0.010504	0	22	78										G	17700285	C	G	17700285	2	3	27	1	0	0	0	0	0	0	0	1	13007	813	29	1		1	RAI1	17	17700285	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	106	17700285	63494925	295	7548			2	24		7	6	1387	N	C	1.07409e-11
RAI1	10743	broad.mit.edu	37	chr17	17700331	17700331	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gggcctctcctggtaatcctCtgagcccatccctttccgac	8	17	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17700331C>A	uc002grm.2	+	3	4538	c.4069C>A	c.(4069-4071)CTG>ATG	p.L1357M	RAI1_uc002grn.1_Missense_Mutation_p.L1357M	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1357						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		TGGTAATCCTCTGAGCCCATC	0.622													1	0	1.67942e-08	0.006122	1.81137e-08	18	94										A	17700331	C	A	17700331	3	1	27	1	0	0	0	0	1	0	0	0	13007	912	32	3	4071	3	RAI1	17	17700331	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	46	17700331	63494879	296	7549			2	24		7	6	1387	N	C	1.07409e-11
RAI1	10743	broad.mit.edu	37	chr17	17700911	17700911	+	Missense_Mutation	SNP	C	C	T													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccgggccaagaacaccacctCttcaccctgtaaggggcgtg							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17700911C>T	uc002grm.2	+	3	5118	c.4649C>T	c.(4648-4650)TCT>TTT	p.S1550F	RAI1_uc002grn.1_Missense_Mutation_p.S1550F	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1550						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		AACACCACCTCTTCACCCTGT	0.612													0	0	0	0.010729	0	10	64										T	17700911	C	T	17700911	3	4	27	1	0	0	0	0	1	0	0	0	13007	913	32	1	4651	1	RAI1	17	17700911	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	580	17700911	63494299	297	7550	35	2	2	24		7	6	1387	N	C	1.07409e-11
RAI1	10743	broad.mit.edu	37	chr17	17700914	17700914	+	Missense_Mutation	SNP	C	C	T													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggccaagaacaccacctcttCaccctgtaaggggcgtgcca							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17700914C>T	uc002grm.2	+	3	5121	c.4652C>T	c.(4651-4653)TCA>TTA	p.S1551L	RAI1_uc002grn.1_Missense_Mutation_p.S1551L	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1551						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		ACCACCTCTTCACCCTGTAAG	0.607													0	0	0	0.010729	0	10	62										T	17700914	C	T	17700914	3	4	27	1	0	0	0	0	1	0	0	0	13007	838	29	1	4654	1	RAI1	17	17700914	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3	17700914	63494296	298	7551	35	2	2	24		7	6	1387	N	C	1.07409e-11
RAI1	10743	broad.mit.edu	37	chr17	17701368	17701368	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttcaaggaccttggggacctCtgtgggccctactaccctga	11	13	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:17701368C>T	uc002grm.2	+	3	5575	c.5106C>T	c.(5104-5106)CTC>CTT	p.L1702L	RAI1_uc002grn.1_Silent_p.L1702L	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1702						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		TTGGGGACCTCTGTGGGCCCT	0.592													0	0	0	0.00308	0	7	48										T	17701368	C	T	17701368	2	4	27	1	0	0	0	0	0	0	0	1	13007	900	32	1		1	RAI1	17	17701368	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	454	17701368	63493842	299	7552			2	24		7	6	1387	N	C	1.07409e-11
SLC13A2	9058	broad.mit.edu	37	chr17	26820718	26820718	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aaggccatcagcatcctattCgtcatcctggtgctgctctg	9	13	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:26820718C>T	uc002hbh.2	+	7	1075	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F	SLC13A2_uc010wal.1_Silent_p.F293F|SLC13A2_uc010wam.1_Silent_p.F292F|SLC13A2_uc010wan.1_Silent_p.F385F|SLC13A2_uc010wao.1_Silent_p.F293F|SLC13A2_uc002hbi.2_Silent_p.F265F	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	336	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GCATCCTATTCGTCATCCTGG	0.577													0	0	0	0.001984	0	7	144										T	26820718	C	T	26820718	2	4	27	1	0	0	0	0	0	0	0	1	14392	883	31	1		1	SLC13A2	17	26820718	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	9119350	26820718	54374492	300	7553										
SUPT6H	6830	broad.mit.edu	37	chr17	27000447	27000447	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	attttgtggaaagcgaggctGaggagtcagaggaagaatac	15	4	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:27000447G>A	uc002hby.2	+	2	118	c.28G>A	c.(28-30)GAG>AAG	p.E10K	SUPT6H_uc010crt.2_Missense_Mutation_p.E10K	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	10	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					AAGCGAGGCTGAGGAGTCAGA	0.483													0	0	0	0.00308	0	8	47										A	27000447	G	A	27000447	3	1	27	1	0	0	0	0	1	0	0	0	15397	1291	45	1	30	1	SUPT6H	17	27000447	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	179729	27000447	54194763	301	7554										
MYO18A	399687	broad.mit.edu	37	chr17	27421806	27421806	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gactcttgggaagaaatgtcCtggagctctgcctctagaga	12	9	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:27421806C>T	uc002hdt.1	-	30	4730	c.4572G>A	c.(4570-4572)CAG>CAA	p.Q1524Q	MYO18A_uc010wbc.1_Silent_p.Q1066Q|MYO18A_uc002hds.2_Silent_p.Q1066Q|MYO18A_uc010csa.1_Silent_p.Q1524Q|MYO18A_uc002hdu.1_Silent_p.Q1524Q	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1524	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AAGAAATGTCCTGGAGCTCTG	0.537													0	0	0	0.008291	0	10	264										T	27421806	C	T	27421806	2	4	27	1	0	0	0	0	0	0	0	1	10065	680	24	2		2	MYO18A	17	27421806	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	421359	27421806	53773404	302	7555										
C17orf42	79736	broad.mit.edu	37	chr17	29227537	29227537	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatcaaggtgagcccaggcaAttcttcgagtaccaaaaacg	10	10	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:29227537A>G	uc002hfu.2	-	3	609	c.539T>C	c.(538-540)ATT>ACT	p.I180T	C17orf42_uc002hfv.2_RNA|C17orf42_uc002hfw.2_Missense_Mutation_p.I180T	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	180					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				AGCCCAGGCAATTCTTCGAGT	0.338													0	0	0	0.00333	0	21	171										G	29227537	A	G	29227537	3	3	27	1	0	0	0	0	1	0	0	0	1856	101	4	5	551	5	C17orf42	17	29227537	Missense_Mutation	SNP	A	TCGA-CF-A1HR-01A-11D-A13W-08	1805731	29227537	51967673	303	7556										
NF1	4763	broad.mit.edu	37	chr17	29576080	29576080	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aagttcttccatgccatcatCagttcctcctcagaattccc	4	15	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:29576080C>G	uc002hgg.2	+	30	4386	c.4053C>G	c.(4051-4053)ATC>ATG	p.I1351M	NF1_uc002hgh.2_Missense_Mutation_p.I1351M|NF1_uc010csn.1_Missense_Mutation_p.I1211M|NF1_uc002hgi.1_Missense_Mutation_p.I384M	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1351	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGCCATCATCAGTTCCTCCT	0.388			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.00278	0	24	260										G	29576080	C	G	29576080	3	3	27	1	0	0	0	0	1	0	0	0	10356	816	29	1	4232	1	NF1	17	29576080	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	348543	29576080	51619130	304	7557										
ACACA	31	broad.mit.edu	37	chr17	35512649	35512649	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgttcacaatggacagagttGagagcactgactctcttata	9	8	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:35512649G>A	uc002hnm.2	-	43	5483	c.5292C>T	c.(5290-5292)CTC>CTT	p.L1764L	ACACA_uc002hnk.2_Silent_p.L1686L|ACACA_uc002hnl.2_Silent_p.L1706L|ACACA_uc002hnn.2_Silent_p.L1764L|ACACA_uc002hno.2_Silent_p.L1801L|ACACA_uc010cuy.2_Silent_p.L409L|ACACA_uc010wdc.1_5'UTR	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1764	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GGACAGAGTTGAGAGCACTGA	0.358													0	0	0	0.01441	0	43	312										A	35512649	G	A	35512649	2	1	27	1	0	0	0	0	0	0	0	1	106	1277	45	1		1	ACACA	17	35512649	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5936569	35512649	45682561	305	7558										
LASP1	3927	broad.mit.edu	37	chr17	37046755	37046755	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aacagagtgagctccagagtCaggtgaggggctgggcggtg	19	7	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:37046755C>T	uc002hra.2	+	3	578	c.247C>T	c.(247-249)CAG>TAG	p.Q83*	LASP1_uc010wdy.1_Nonsense_Mutation_p.Q83*|LASP1_uc010cvq.2_5'UTR|LASP1_uc010wdz.1_Intron	NM_006148	NP_006139	Q14847	LASP1_HUMAN	LIM and SH3 protein 1	83	Nebulin 1.					cortical actin cytoskeleton	ion transmembrane transporter activity|SH3/SH2 adaptor activity|zinc ion binding			lung(1)	1						GCTCCAGAGTCAGGTGAGGGG	0.597			T	MLL	AML								0	0	0	0.00245	0	13	67										T	37046755	C	T	37046755	4	4	27	1	0	0	0	0	0	1	0	0	8637	827	29	1	257	1	LASP1	17	37046755	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1534106	37046755	44148455	306	7559										
KRT24	192666	broad.mit.edu	37	chr17	38857538	38857538	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctctgccggagacacagctCgttctcatacctggaagggg	13	12	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:38857538C>G	uc002hvd.2	-	3	766	c.709G>C	c.(709-711)GAG>CAG	p.E237Q		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	237	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				AGACACAGCTCGTTCTCATAC	0.507													0	0	0	0.001168	0	6	60										G	38857538	C	G	38857538	3	3	27	1	0	0	0	0	1	0	0	0	8461	893	31	1	892	1	KRT24	17	38857538	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1810783	38857538	42337672	307	7560										
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39262231	39262231	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgcccaacctgtgtcatctcCagctgcccccgccccttgtg	8	20	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:39262231C>A	uc010wfp.1	+	1	591	c.591C>A	c.(589-591)TCC>TCA	p.S197S		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	197						keratin filament					0						GTGTCATCTCCAGCTGCCCCC	0.512													1	0	2.74318e-10	0.006214	2.96578e-10	6	4										A	39262231	C	A	39262231	2	1	27	1	0	0	0	0	0	0	0	1	8557	581	21	4		4	KRTAP4-9	17	39262231	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	404693	39262231	41932979	308	7561										
KLHL11	55175	broad.mit.edu	37	chr17	40011443	40011443	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gaaatttctccgtatcatatCagcagccttcagagcaagtt	7	10	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:40011443C>G	uc002hyf.1	-	2	682	c.676G>C	c.(676-678)GAT>CAT	p.D226H		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	226	BACK.					extracellular region					0		Breast(137;0.00156)				CGTATCATATCAGCAGCCTTC	0.383													0	0	0	0.01441	0	44	162										G	40011443	C	G	40011443	3	3	27	1	0	0	0	0	1	0	0	0	8367	826	29	1	1454	1	KLHL11	17	40011443	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	749212	40011443	41183767	309	7562										
ACLY	47	broad.mit.edu	37	chr17	40068681	40068681	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atgcccactcactgtggcttCctgtcccagccgtggcttca	9	16	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:40068681C>T	uc002hyg.2	-	3	437	c.274G>A	c.(274-276)GAA>AAA	p.E92K	ACLY_uc002hyh.2_Missense_Mutation_p.E92K|ACLY_uc002hyi.2_Missense_Mutation_p.E146K|ACLY_uc010wfx.1_Missense_Mutation_p.E146K|ACLY_uc010wfy.1_Missense_Mutation_p.E92K	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	92					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				ACTGTGGCTTCCTGTCCCAGC	0.567													0	0	0	0.010729	0	7	111										T	40068681	C	T	40068681	3	4	27	1	0	0	0	0	1	0	0	0	143	864	30	1	3139	1	ACLY	17	40068681	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	57238	40068681	41126529	310	7563										
KAT2A	2648	broad.mit.edu	37	chr17	40271680	40271680	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tttgagagctcgaacatcgtCtgccgctcccggggagccag	13	13	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:40271680C>G	uc002hyx.2	-	5	816	c.756G>C	c.(754-756)CAG>CAC	p.Q252H		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	252					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						CGAACATCGTCTGCCGCTCCC	0.547													0	0	0	0.012319	0	19	63										G	40271680	C	G	40271680	3	3	27	1	0	0	0	0	1	0	0	0	7981	912	32	1	1813	1	KAT2A	17	40271680	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	202999	40271680	40923530	311	7564										
GRN	2896	broad.mit.edu	37	chr17	42427695	42427696	+	Frame_Shift_Ins	INS	-	-	CC													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gatggctcctgggggtgctgINSccccatgccccaggtacaaa							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:42427695_42427696insCC	uc002igp.1	+	5	668_669	c.449_450insCC	c.(448-450)TGCfs	p.C150fs	GRN_uc002igq.1_3'UTR|GRN_uc002igr.1_5'Flank	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	150					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGGGGGTGCTGCCCCATGCCCC	0.619																		12	225	---	---								CC	42427696	-	CC	42427695	7	5	27	1	0	1	1	0	0	0	0	0	6804	1319	46	0	463	0	GRN	17	42427695	Frame_Shift_Ins	INS	-	TCGA-CF-A1HR-01A-11D-A13W-08	2156015	42427695	38767515	312	7565										
CALCOCO2	10241	broad.mit.edu	37	chr17	46926617	46926617	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggaatgttcttttgtagggaGaggtggaagagattgagcag	17	2	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:46926617G>A	uc002iof.2	+	5	500	c.421G>A	c.(421-423)GAG>AAG	p.E141K	CALCOCO2_uc010wlp.1_Missense_Mutation_p.E162K|CALCOCO2_uc010wlq.1_Missense_Mutation_p.E69K|CALCOCO2_uc010wlr.1_Missense_Mutation_p.E165K|CALCOCO2_uc010wls.1_Intron	NM_005831	NP_005822	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	141	Potential.				response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			ovary(1)	1						TTTGTAGGGAGAGGTGGAAGA	0.463													0	0	0	0.003271	0	34	107										A	46926617	G	A	46926617	3	1	27	1	0	0	0	0	1	0	0	0	2578	943	33	1	435	1	CALCOCO2	17	46926617	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4498922	46926617	34268593	313	7566										
SLC35B1	10237	broad.mit.edu	37	chr17	47780327	47780327	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttcgagttgtagtgatgatgGagcaggtcaggggaccaaaa	15	5	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:47780327G>C	uc002iph.1	-	8	896	c.809C>G	c.(808-810)TCC>TGC	p.S270C	SLC35B1_uc002ipi.1_Missense_Mutation_p.S203C|SLC35B1_uc002ipj.1_Missense_Mutation_p.S146C	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	270						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						AGTGATGATGGAGCAGGTCAG	0.502													0	0	0	0.004482	0	8	127										C	47780327	G	C	47780327	3	2	27	1	0	0	0	0	1	0	0	0	14575	1174	41	1	167	1	SLC35B1	17	47780327	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	853710	47780327	33414883	314	7567										
MRPL27	51264	broad.mit.edu	37	chr17	48445522	48445522	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acgtggacaaaagtcttgtaGagcacagcacccttgggcag	12	10	1	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:48445522G>C	uc002iqq.2	-	4	409	c.378C>G	c.(376-378)CTC>CTG	p.L126L	MRPL27_uc002iqr.2_3'UTR	NM_016504	NP_057588	Q9P0M9	RM27_HUMAN	mitochondrial ribosomal protein L27	126					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;1.73e-07)			AAGTCTTGTAGAGCACAGCAC	0.547													0	0	0	0.014323	0	22	57										C	48445522	G	C	48445522	2	2	27	1	0	0	0	0	0	0	0	1	9791	929	33	1		1	MRPL27	17	48445522	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	665195	48445522	32749688	315	7568										
UTP18	51096	broad.mit.edu	37	chr17	49374347	49374347	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgcaccattactcagacttCtaaagagactatttgaagta	6	8	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:49374347C>G	uc002its.2	+	13	1717	c.1668C>G	c.(1666-1668)TTC>TTG	p.F556L		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	556				GKALMYRLHHYSDF -> ARP (in Ref. 1; AAD34043).	rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			ACTCAGACTTCTAAAGAGACT	0.373													0	0	0	0.003163	0	16	167										G	49374347	C	G	49374347	3	3	27	1	0	0	0	0	1	0	0	0	17095	912	32	1	1718	1	UTP18	17	49374347	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	928825	49374347	31820863	316	7569										
MPO	4353	broad.mit.edu	37	chr17	56349051	56349051	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agcttcctgaactgggtaccGatgatgcaggcgaggagtgg	16	8	0	2	rs141229223	byFrequency	TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:56349051G>A	uc002ivu.1	-	11	2172	c.1995C>T	c.(1993-1995)ATC>ATT	p.I665I		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	665					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	ACTGGGTACCGATGATGCAGG	0.647													0	0	0	0.001984	0	5	46										A	56349051	G	A	56349051	2	1	27	1	0	0	0	0	0	0	0	1	9732	1048	37	1		1	MPO	17	56349051	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	6974704	56349051	24846159	317	7570										
MPO	4353	broad.mit.edu	37	chr17	56350157	56350157	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	catgttcagagcaggcaggtCcagcccaatcctcatgacct	9	14	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:56350157C>G	uc002ivu.1	-	10	1921	c.1744G>C	c.(1744-1746)GAC>CAC	p.D582H		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	582					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	GCAGGCAGGTCCAGCCCAATC	0.617													0	0	0	0.010729	0	12	210										G	56350157	C	G	56350157	3	3	27	1	0	0	0	0	1	0	0	0	9732	855	30	1	505	1	MPO	17	56350157	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1106	56350157	24845053	318	7571										
C17orf47	284083	broad.mit.edu	37	chr17	56620137	56620137	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctctggaacttcagatcctCacagaaagggctagagtcta	9	10	4	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:56620137C>G	uc002iwq.1	-	1	1547	c.1411G>C	c.(1411-1413)GAG>CAG	p.E471Q	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	471										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTCAGATCCTCACAGAAAGGG	0.493													0	0	0	0.008361	0	30	462										G	56620137	C	G	56620137	3	3	27	1	0	0	0	0	1	0	0	0	1858	835	29	1	309	1	C17orf47	17	56620137	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	269980	56620137	24575073	319	7572										
USP32	84669	broad.mit.edu	37	chr17	58286164	58286164	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aatccacaacaattgatctaTttcttcttagatggttgtcc	5	9	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:58286164T>C	uc002iyo.1	-	23	2910	c.2624A>G	c.(2623-2625)AAT>AGT	p.N875S	USP32_uc002iyn.1_Missense_Mutation_p.N545S	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	875					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AATTGATCTATTTCTTCTTAG	0.348													0	0	0	0.006122	0	14	115										C	58286164	T	C	58286164	3	2	27	1	0	0	0	0	1	0	0	0	17060	1493	52	5	2238	5	USP32	17	58286164	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	1666027	58286164	22909046	320	7573										
FBF1	85302	broad.mit.edu	37	chr17	73922925	73922925	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tggtgattcctccttcatcaTaggagagaagtcctctcaat	8	10	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:73922925T>C	uc002jqc.2	-	9	741	c.467A>G	c.(466-468)TAT>TGT	p.Y156C	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.Y146C|FBF1_uc002jqd.1_Missense_Mutation_p.Y156C	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	156											0						TCCTTCATCATAGGAGAGAAG	0.512													0	0	0	0.004482	0	8	21										C	73922925	T	C	73922925	3	2	27	1	0	0	0	0	1	0	0	0	5695	1406	49	5	3018	5	FBF1	17	73922925	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	15636761	73922925	7272285	321	7574										
PRPSAP1	5635	broad.mit.edu	37	chr17	74307742	74307742	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctttatcttgggacattgcaGcttctgaacctcatgaggga	10	9	3	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:74307742G>A	uc010wta.1	-	10	1485	c.1039C>T	c.(1039-1041)CTG>TTG	p.L347L	PRPSAP1_uc010wtb.1_Silent_p.L244L	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	318					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1						GGACATTGCAGCTTCTGAACC	0.453													0	0	0	0.008871	0	19	102										A	74307742	G	A	74307742	2	1	27	1	0	0	0	0	0	0	0	1	12581	962	34	2		2	PRPSAP1	17	74307742	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	384817	74307742	6887468	322	7575										
RNF213	57674	broad.mit.edu	37	chr17	78343329	78343329	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	attgaaaagcatgcccgcttCcggcagatgtgcaacagttt	10	10	0	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:78343329C>T	uc002jyh.1	+	20	6625	c.6402C>T	c.(6400-6402)TTC>TTT	p.F2134F	uc002jyi.1_Intron|RNF213_uc010dhw.1_Silent_p.F516F	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATGCCCGCTTCCGGCAGATGT	0.493													0	0	0	0.01441	0	62	177										T	78343329	C	T	78343329	2	4	27	1	0	0	0	0	0	0	0	1	13477	854	30	1		1	RNF213	17	78343329	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4035587	78343329	2851881	323	7576										
RNF213	57674	broad.mit.edu	37	chr17	78343399	78343399	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcaaggacaacgctccgcctGagaaggaagtgattgagagc	13	9	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:78343399G>A	uc002jyh.1	+	20	6695	c.6472G>A	c.(6472-6474)GAG>AAG	p.E2158K	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.E540K	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CGCTCCGCCTGAGAAGGAAGT	0.517													0	0	0	0.009718	0	42	139										A	78343399	G	A	78343399	3	1	27	1	0	0	0	0	1	0	0	0	13477	1291	45	1	12746	1	RNF213	17	78343399	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	70	78343399	2851811	324	7577										
NARF	26502	broad.mit.edu	37	chr17	80439027	80439027	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acaagaagctggaggctcttCaggaaagccttccccctgct	10	13	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr17:80439027C>T	uc002kfg.3	+	7	849	c.709C>T	c.(709-711)CAG>TAG	p.Q237*	NARF_uc002kff.3_Nonsense_Mutation_p.Q178*|NARF_uc010wvo.1_Nonsense_Mutation_p.Q192*|NARF_uc010wvp.1_Nonsense_Mutation_p.Q109*|NARF_uc010dit.2_Nonsense_Mutation_p.Q237*|NARF_uc002kfj.3_Nonsense_Mutation_p.Q189*|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Nonsense_Mutation_p.Q283*|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	237						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GGAGGCTCTTCAGGAAAGCCT	0.577													0	0	0	0.013537	0	13	182										T	80439027	C	T	80439027	4	4	27	1	0	0	0	0	0	1	0	0	10167	827	29	1	735	1	NARF	17	80439027	Nonsense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2095628	80439027	756183	325	7578										
LAMA1	284217	broad.mit.edu	37	chr18	7038844	7038844	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agagaggctgctgcagacatCagaaacgccaaagcagaagc	12	10	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:7038844C>T	uc002knm.2	-	11	1622	c.1528G>A	c.(1528-1530)GAT>AAT	p.D510N	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	510	Laminin EGF-like 5; first part.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCAGACATCAGAAACGCCA	0.567													0	0	0	0.003163	0	15	179										T	7038844	C	T	7038844	3	4	27	1	0	0	0	0	1	0	0	0	8605	826	29	1	7911	1	LAMA1	18	7038844	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		7038844	71038404	326	7579										
CEP76	79959	broad.mit.edu	37	chr18	12702511	12702511	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cagctgctggtggatgagctGcttcagctcggaggctttct	14	10	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:12702511G>A	uc002kri.2	-	1	193	c.37C>T	c.(37-39)CAG>TAG	p.Q13*	PSMG2_uc002krg.2_Intron|PSMG2_uc002krj.1_5'Flank|PSMG2_uc002krk.2_5'Flank|CEP76_uc002krh.3_5'UTR|CEP76_uc010wzz.1_Nonsense_Mutation_p.Q13*|CEP76_uc010xaa.1_5'Flank|CEP76_uc010xab.1_Nonsense_Mutation_p.Q13*	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	13					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						TGGATGAGCTGCTTCAGCTCG	0.706													0	0	0	0.001984	0	7	23										A	12702511	G	A	12702511	4	1	27	1	0	0	0	0	0	1	0	0	3261	1328	46	2	1990	2	CEP76	18	12702511	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	5663667	12702511	65374737	327	7580										
ELP2	55250	broad.mit.edu	37	chr18	33738801	33738801	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tatattttctattctagcaaGatagtgatcttccagaagga	7	6	3	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:33738801G>T	uc002kzk.1	+	14	1478	c.1468G>T	c.(1468-1470)GAT>TAT	p.D490Y	ELP2_uc010xcg.1_Missense_Mutation_p.D555Y|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.D464Y|ELP2_uc010xch.1_Missense_Mutation_p.D485Y|ELP2_uc002kzn.1_Missense_Mutation_p.D420Y|ELP2_uc002kzo.1_Missense_Mutation_p.D420Y	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	490					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						ATTCTAGCAAGATAGTGATCT	0.308													1	0	1.28384e-07	0.012319	1.37489e-07	20	75										T	33738801	G	T	33738801	3	4	27	1	0	0	0	0	1	0	0	0	5080	942	33	3	1522	3	ELP2	18	33738801	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	21036290	33738801	44338447	328	7581										
KIAA1632	57724	broad.mit.edu	37	chr18	43495477	43495477	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctctcagtgagtttcctaccTgagtgggcgtggccaagccc	12	13	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:43495477T>A	uc002lbm.2	-	20	3792	c.3692A>T	c.(3691-3693)CAG>CTG	p.Q1231L	KIAA1632_uc002lbo.1_Missense_Mutation_p.Q1231L|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.Q106L	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1231					autophagy						0						GTTTCCTACCTGAGTGGGCGT	0.418													0	0	0	0.00333	0	26	84										A	43495477	T	A	43495477	3	1	27	1	0	0	0	0	1	0	0	0	8249	1594	55	5	4147	5	KIAA1632	18	43495477	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08	9756676	43495477	34581771	329	7582										
TCEB3B	51224	broad.mit.edu	37	chr18	44559494	44559494	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcgtgctcattgctgctgctCaggcaggggttggcccgctt	15	12	2	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:44559494C>T	uc002lcr.1	-	1	2495	c.2142G>A	c.(2140-2142)CTG>CTA	p.L714L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	714					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TGCTGCTGCTCAGGCAGGGGT	0.522													0	0	0	0.014323	0	20	55										T	44559494	C	T	44559494	2	4	27	1	0	0	0	0	0	0	0	1	15679	813	29	1		1	TCEB3B	18	44559494	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1064017	44559494	33517754	330	7583										
KATNAL2	83473	broad.mit.edu	37	chr18	44589673	44589673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aggaacgactgctgaaacctCtgagtgcatttattggcatg	11	8	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:44589673C>T	uc002lco.2	+	7	645	c.451C>T	c.(451-453)CTG>TTG	p.L151L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Silent_p.L111L	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	223						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						GCTGAAACCTCTGAGTGCATT	0.468													0	0	0	0.009096	0	4	61										T	44589673	C	T	44589673	2	4	27	1	0	0	0	0	0	0	0	1	7986	912	32	1		1	KATNAL2	18	44589673	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	30179	44589673	33487575	331	7584										
DCC	1630	broad.mit.edu	37	chr18	50592482	50592482	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcttttatcaatgtgtggctGaaaatgaggctggaaatgcc	12	6	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:50592482G>A	uc002lfe.1	+	7	1794	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	DCC_uc010xdr.1_Missense_Mutation_p.E251K|DCC_uc010dpf.1_Missense_Mutation_p.E58K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	403	Extracellular (Potential).|Ig-like C2-type 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ATGTGTGGCTGAAAATGAGGC	0.438													0	0	0	0.007413	0	19	150										A	50592482	G	A	50592482	3	1	27	1	0	0	0	0	1	0	0	0	4282	1291	45	1	1233	1	DCC	18	50592482	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	6002809	50592482	27484766	332	7585										
ZNF236	7776	broad.mit.edu	37	chr18	74587572	74587572	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccttctgtcctgccgccttCtctcagaaagggaatcttca	8	14	5	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr18:74587572C>T	uc002lmi.2	+	6	984	c.786C>T	c.(784-786)TTC>TTT	p.F262F	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Silent_p.F262F	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	262	C2H2-type 8.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CTGCCGCCTTCTCTCAGAAAG	0.532											OREG0025069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	10	137										T	74587572	C	T	74587572	2	4	27	1	0	0	0	0	0	0	0	1	17786	912	32	1		1	ZNF236	18	74587572	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	23995090	74587572	3489676	333	7586										
MADCAM1	8174	broad.mit.edu	37	chr19	504758	504758	+	Frame_Shift_Del	DEL	G	G	-													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccccagcgtccaaacctgcGggtgaccagctgcccgcggc							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:504758delG	uc002los.2	+	5	952	c.942delG	c.(940-942)GCGfs	p.A314fs	MADCAM1_uc002lot.2_Frame_Shift_Del_p.A227fs|MADCAM1_uc010drq.2_Frame_Shift_Del_p.A132fs|C19orf20_uc002lou.2_5'Flank	NM_130760	NP_570116	Q13477	MADCA_HUMAN	mucosal vascular addressin cell adhesion	314	Extracellular (Potential).|Mucin-like.				cell adhesion|immune response|regulation of immune response|signal transduction	integral to membrane|membrane fraction|plasma membrane					0		all_cancers(10;4.25e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAACCTGCGGGTGACCAGC	0.672																		15	113	---	---								-	504758	G	-	504758	7	5	27	1	0	1	0	1	0	0	0	0	9151	1103	39	0	960	0	MADCAM1	19	504758	Frame_Shift_Del	DEL	G	TCGA-CF-A1HR-01A-11D-A13W-08		504758	58624225	334	7587										
SLC39A3	29985	broad.mit.edu	37	chr19	2737188	2737188	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgatcttcacggggagcaggGagccgagcagcatgaagaag	16	8	2	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:2737188G>C	uc002lwg.2	-	2	322	c.68C>G	c.(67-69)TCC>TGC	p.S23C	SLC39A3_uc010xgy.1_Missense_Mutation_p.S23C|SLC39A3_uc002lwh.2_Missense_Mutation_p.S23C	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	23	Helical; (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGAGCAGGGAGCCGAGCAG	0.547													0	0	0	0.004672	0	3	27										C	2737188	G	C	2737188	3	2	27	1	0	0	0	0	1	0	0	0	14619	1174	41	1	992	1	SLC39A3	19	2737188	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2232430	2737188	56391795	335	7588										
MATK	4145	broad.mit.edu	37	chr19	3781668	3781668	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctgcaggttcagtaaccagcCcgctgtggagtgaagaccca	12	12	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:3781668C>T	uc002lyt.2	-	8	1079	c.679G>A	c.(679-681)GGC>AGC	p.G227S	MATK_uc002lyv.2_Missense_Mutation_p.G228S|MATK_uc002lyu.2_Missense_Mutation_p.G186S|MATK_uc010dtq.2_Missense_Mutation_p.G227S	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	227					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTAACCAGCCCGCTGTGGAG	0.557													0	0	0	0.009096	0	3	41										T	3781668	C	T	3781668	3	4	27	1	0	0	0	0	1	0	0	0	9332	623	22	2	872	2	MATK	19	3781668	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1044480	3781668	55347315	336	7589										
INSR	3643	broad.mit.edu	37	chr19	7174599	7174599	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cacagagacactcactgcctCctcgaatgttgatgatcaga	8	12	2	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:7174599C>T	uc002mgd.1	-	4	1227	c.1118G>A	c.(1117-1119)GGA>GAA	p.G373E	INSR_uc002mge.1_Missense_Mutation_p.G373E|INSR_uc002mgf.2_Missense_Mutation_p.G373E	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	373					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCACTGCCTCCTCGAATGTT	0.602													0	0	0	0.004482	0	9	49										T	7174599	C	T	7174599	3	4	27	1	0	0	0	0	1	0	0	0	7773	855	30	1	3106	1	INSR	19	7174599	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3392931	7174599	51954384	337	7590										
ZNF441	126068	broad.mit.edu	37	chr19	11891441	11891441	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcagttgttcctgttacactCaactatatgaaaggactcac	6	10	3	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:11891441C>G	uc010dyj.2	+	4	996	c.802C>G	c.(802-804)CAA>GAA	p.Q268E	ZNF441_uc002msn.3_Missense_Mutation_p.Q224E	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	268	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTGTTACACTCAACTATATGA	0.383													0	0	0	0.009096	0	4	117										G	11891441	C	G	11891441	3	3	27	1	0	0	0	0	1	0	0	0	17911	827	29	1	816	1	ZNF441	19	11891441	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4716842	11891441	47237542	338	7591										
MYO9B	4650	broad.mit.edu	37	chr19	17305659	17305659	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctgaaagtcacgagaaagtCcccagcagccgggagaagcg	14	11	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:17305659C>G	uc010eak.2	+	22	3575	c.3423C>G	c.(3421-3423)GTC>GTG	p.V1141V	MYO9B_uc002nfi.2_Silent_p.V1141V|MYO9B_uc002nfj.1_Silent_p.V1141V	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1141	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						ACGAGAAAGTCCCCAGCAGCC	0.607													0	0	0	0.009096	0	4	26										G	17305659	C	G	17305659	2	3	27	1	0	0	0	0	0	0	0	1	10085	842	30	1		1	MYO9B	19	17305659	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5414218	17305659	41823324	339	7592										
ANO8	57719	broad.mit.edu	37	chr19	17440962	17440962	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ttgagccagatggctagcttCttgtagccctcggcactcac	10	13	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:17440962C>T	uc002ngf.2	-	10	1404	c.1245G>A	c.(1243-1245)AAG>AAA	p.K415K	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	415	Helical; (Potential).|Leu-rich.					chloride channel complex	chloride channel activity			ovary(3)	3						TGGCTAGCTTCTTGTAGCCCT	0.627													0	0	0	0.000602	0	5	54										T	17440962	C	T	17440962	2	4	27	1	0	0	0	0	0	0	0	1	703	912	32	1		1	ANO8	19	17440962	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	135303	17440962	41688021	340	7593										
ZNF682	91120	broad.mit.edu	37	chr19	20117297	20117297	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcttcacatttatagggtttCtctcccgtatgggttctctc	7	11	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:20117297C>T	uc002noq.2	-	4	1137	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	ZNF682_uc002noo.2_Silent_p.E306E|ZNF682_uc002nop.2_Silent_p.E306E|ZNF682_uc010eck.2_Silent_p.E262E	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TATAGGGTTTCTCTCCCGTAT	0.383													0	0	0	0.003954	0	23	114										T	20117297	C	T	20117297	2	4	27	1	0	0	0	0	0	0	0	1	18086	912	32	1		1	ZNF682	19	20117297	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2676335	20117297	39011686	341	7594										
SLC7A9	11136	broad.mit.edu	37	chr19	33359415	33359415	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcgacttctcatcctctctcCgctttctcaggccagtatcc	5	17	3	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:33359415C>T	uc002ntv.3	-	2	143	c.26G>A	c.(25-27)CGG>CAG	p.R9Q	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Missense_Mutation_p.R9Q|SLC7A9_uc002ntw.3_5'UTR	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	9	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	ATCCTCTCTCCGCTTTCTCAG	0.557													0	0	0	0.014323	0	20	148										T	33359415	C	T	33359415	3	4	27	1	0	0	0	0	1	0	0	0	14705	652	23	2	1485	2	SLC7A9	19	33359415	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	13242118	33359415	25769568	342	7595										
ZNF793	390927	broad.mit.edu	37	chr19	38028585	38028585	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agaaagaccgtatcgttgcaGagaatgtggaaaatccttca	10	7	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:38028585G>C	uc010efm.2	+	8	1467	c.1025G>C	c.(1024-1026)AGA>ACA	p.R342T	ZNF793_uc010xts.1_Missense_Mutation_p.R342T|ZNF793_uc010efo.2_Intron	NM_001013659	NP_001013681	Q6ZN11	ZN793_HUMAN	zinc finger protein 793	342	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATCGTTGCAGAGAATGTGGA	0.453													0	0	0	0.000602	0	4	70										C	38028585	G	C	38028585	3	2	27	1	0	0	0	0	1	0	0	0	18162	942	33	1	1039	1	ZNF793	19	38028585	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	4669170	38028585	21100398	343	7596										
SAMD4B	55095	broad.mit.edu	37	chr19	39868169	39868169	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cgaaacgctctgcaggagctGcagcagatcatcatcactcc	9	14	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:39868169G>A	uc002olb.2	+	10	2184	c.1149G>A	c.(1147-1149)CTG>CTA	p.L383L	SAMD4B_uc002ola.2_Silent_p.L383L	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	383							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TGCAGGAGCTGCAGCAGATCA	0.627													0	0	0	0.001168	0	5	75										A	39868169	G	A	39868169	2	1	27	1	0	0	0	0	0	0	0	1	13822	1306	46	2		2	SAMD4B	19	39868169	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1839584	39868169	19260814	344	7597										
PSG5	5673	broad.mit.edu	37	chr19	43680125	43680125	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctcgtgacactgggtagaatGaggatcctgttttcaatggg	13	7	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:43680125G>A	uc002ovu.2	-	3	737	c.606C>T	c.(604-606)CTC>CTT	p.L202L	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Silent_p.L202L|PSG5_uc002ovv.2_Silent_p.L295L|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	202	Ig-like C2-type 1.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				TGGGTAGAATGAGGATCCTGT	0.507													0	0	0	0.00308	0	6	277										A	43680125	G	A	43680125	2	1	27	1	0	0	0	0	0	0	0	1	12658	1277	45	1		1	PSG5	19	43680125	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3811956	43680125	15448858	345	7598										
PLAUR	5329	broad.mit.edu	37	chr19	44169603	44169603	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tttctccaccagctccagctCttctccttctgcaaggaggg	8	15	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:44169603C>T	uc002oxf.1	-	3	405	c.175G>A	c.(175-177)GAG>AAG	p.E59K	PLAUR_uc002oxd.1_Missense_Mutation_p.E59K|PLAUR_uc002oxe.1_Missense_Mutation_p.E54K|PLAUR_uc002oxg.1_Missense_Mutation_p.E59K	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	59	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	AGCTCCAGCTCTTCTCCTTCT	0.557													0	0	0	0.001168	0	6	89										T	44169603	C	T	44169603	3	4	27	1	0	0	0	0	1	0	0	0	12023	922	32	1	948	1	PLAUR	19	44169603	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	489478	44169603	14959380	346	7599										
ZNF285	26974	broad.mit.edu	37	chr19	44896514	44896514	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agttactcactcactaacatGaggttcctgaagttttccag	7	10	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:44896514G>A	uc002ozd.3	-	3	219	c.132C>T	c.(130-132)CTC>CTT	p.L44L	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Silent_p.L51L	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TCACTAACATGAGGTTCCTGA	0.428													0	0	0	0.00499	0	16	192										A	44896514	G	A	44896514	2	1	27	1	0	0	0	0	0	0	0	1	17819	1277	45	1		1	ZNF285	19	44896514	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	726911	44896514	14232469	347	7600										
CCDC9	26093	broad.mit.edu	37	chr19	47761897	47761897	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aggctcttcggcggaagaatGaggccctcatccggcgctac	13	13	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:47761897G>C	uc010xym.1	+	3	292	c.85G>C	c.(85-87)GAG>CAG	p.E29Q		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	29											0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		GCGGAAGAATGAGGCCCTCAT	0.552													0	0	0	0.009096	0	3	74										C	47761897	G	C	47761897	3	2	27	1	0	0	0	0	1	0	0	0	2867	1291	45	1	91	1	CCDC9	19	47761897	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	2865383	47761897	11367086	348	7601										
VN1R4	317703	broad.mit.edu	37	chr19	53770061	53770061	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tatacactggggtcacagctCatgagaacaaaggggctgag	13	8	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:53770061C>G	uc010ydu.1	-	1	858	c.858G>C	c.(856-858)ATG>ATC	p.M286I		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	286	Cytoplasmic (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		GGTCACAGCTCATGAGAACAA	0.393										HNSCC(26;0.072)			0	0	0	0.000602	0	5	82										G	53770061	C	G	53770061	3	3	27	1	0	0	0	0	1	0	0	0	17177	826	29	1	50	1	VN1R4	19	53770061	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	6008164	53770061	5358922	349	7602										
TMC4	147798	broad.mit.edu	37	chr19	54667458	54667458	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccccgtgaggctggaacctGagcaggataaaaacgatctg	12	10	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:54667458G>A	uc010erf.2	-	8	1425	c.1293C>T	c.(1291-1293)CTC>CTT	p.L431L	TMC4_uc002qdn.2_Nonsense_Mutation_p.Q122*|TMC4_uc002qdo.2_Silent_p.L425L	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	431	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCTGGAACCTGAGCAGGATAA	0.567											OREG0003641	type=REGULATORY REGION|Gene=AK124406|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.001168	0	6	74										A	54667458	G	A	54667458	2	1	27	1	0	0	0	0	0	0	0	1	15984	1277	45	1		1	TMC4	19	54667458	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	897397	54667458	4461525	350	7603										
LILRB1	10859	broad.mit.edu	37	chr19	55147018	55147018	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gccccagcagatgctgccgtGaagcacacacagcctgagga	12	14	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr19:55147018G>A	uc002qgj.2	+	14	1948	c.1608G>A	c.(1606-1608)GTG>GTA	p.V536V	LILRB1_uc010erp.1_Silent_p.V151V|LILRB1_uc002qgl.2_Silent_p.V536V|LILRB1_uc002qgk.2_Silent_p.V537V|LILRB1_uc002qgm.2_Silent_p.V537V|LILRB1_uc010erq.2_Silent_p.V520V|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	536	Cytoplasmic (Potential).|ITIM motif 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		ATGCTGCCGTGAAGCACACAC	0.627										HNSCC(37;0.09)			0	0	0	0.00308	0	5	137										A	55147018	G	A	55147018	2	1	27	1	0	0	0	0	0	0	0	1	8790	1277	45	1		1	LILRB1	19	55147018	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	479560	55147018	3981965	351	7604										
UQCC	55245	broad.mit.edu	37	chr20	33969816	33969816	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aacaggctgtggggaatcttTggtagtagaaagctgattaa	13	4	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:33969816T>C	uc002xcd.2	-	4	305	c.238A>G	c.(238-240)AAA>GAA	p.K80E	UQCC_uc010zuy.1_5'UTR|UQCC_uc010zuz.1_Intron|UQCC_uc010zva.1_Intron|UQCC_uc002xce.2_Missense_Mutation_p.K80E|UQCC_uc002xcg.2_5'UTR|UQCC_uc010gfb.2_Missense_Mutation_p.K80E|UQCC_uc010zvb.1_Intron|UQCC_uc002xcf.2_Intron|GDF5_uc010gfc.1_Intron|UQCC_uc002xci.1_Missense_Mutation_p.K34E|UQCC_uc010gfd.1_Missense_Mutation_p.K66E	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform	80						cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGGGAATCTTTGGTAGTAGAA	0.358													0	0	0	0.01441	0	91	251										C	33969816	T	C	33969816	3	2	27	1	0	0	0	0	1	0	0	0	17012	1821	63	5	689	5	UQCC	20	33969816	Missense_Mutation	SNP	T	TCGA-CF-A1HR-01A-11D-A13W-08		33969816	29055704	352	7605										
IFT52	51098	broad.mit.edu	37	chr20	42271258	42271258	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtggtggagttcaagaaattGaaccaggtacagagcctaca	12	7	1	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:42271258G>C	uc002xkw.2	+	13	1382	c.1260G>C	c.(1258-1260)TTG>TTC	p.L420F	IFT52_uc002xky.2_Missense_Mutation_p.L420F|IFT52_uc002xkx.2_RNA|IFT52_uc010ggn.2_Missense_Mutation_p.L396F|IFT52_uc002xkz.2_Intron	NM_016004	NP_057088	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog	420						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			ovary(2)	2		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TCAAGAAATTGAACCAGGTAC	0.463													0	0	0	0.001984	0	5	60										C	42271258	G	C	42271258	3	2	27	1	0	0	0	0	1	0	0	0	7561	1281	45	1	1306	1	IFT52	20	42271258	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	8301442	42271258	20754262	353	7606										
MMP9	4318	broad.mit.edu	37	chr20	44640217	44640217	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	atcctcctcgccccaggactCtacacccaggacggcaatgc	8	18	1	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:44640217C>G	uc002xqz.2	+	6	847	c.828C>G	c.(826-828)CTC>CTG	p.L276L		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	276					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CCCCAGGACTCTACACCCAGG	0.577											OREG0025989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	66										G	44640217	C	G	44640217	2	3	27	1	0	0	0	0	0	0	0	1	9669	900	32	1		1	MMP9	20	44640217	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	2368959	44640217	18385303	354	7607										
DDX27	55661	broad.mit.edu	37	chr20	47841697	47841697	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tctcagtacgatgaaaacctCtcgttccaggacatgaacct	7	12	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:47841697C>T	uc002xuh.2	+	6	715	c.654C>T	c.(652-654)CTC>CTT	p.L218L		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	218	Q motif.					nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATGAAAACCTCTCGTTCCAGG	0.338													0	0	0	0.007413	0	17	238										T	47841697	C	T	47841697	2	4	27	1	0	0	0	0	0	0	0	1	4354	900	32	1		1	DDX27	20	47841697	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3201480	47841697	15183823	355	7608										
PCK1	5105	broad.mit.edu	37	chr20	56136548	56136549	+	Frame_Shift_Ins	INS	-	-	C													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	acagcctaccccaggcagtgINSagggagtttctcgagaataa							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:56136548_56136549insC	uc002xyn.3	+	2	244_245	c.81_82insC	c.(79-84)GTGAGGfs	p.V27fs	PCK1_uc010zzm.1_5'UTR	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	27_28					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCCAGGCAGTGAGGGAGTTTCT	0.569																		15	215	---	---								C	56136549	-	C	56136548	7	5	27	1	0	1	1	0	0	0	0	0	11581	1277	45	0	83	0	PCK1	20	56136548	Frame_Shift_Ins	INS	-	TCGA-CF-A1HR-01A-11D-A13W-08	8294851	56136548	6888972	356	7609										
STX16	8675	broad.mit.edu	37	chr20	57251299	57251299	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtgattttaatattatttgtCatcatcattgtgctcattgt	6	5	4	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:57251299C>T	uc002xzi.2	+	9	1665	c.930C>T	c.(928-930)GTC>GTT	p.V310V	STX16_uc010zzq.1_Silent_p.V124V|STX16_uc002xzk.2_Silent_p.V293V|STX16_uc002xzm.2_Silent_p.V306V|STX16_uc002xzj.2_Silent_p.V289V|STX16_uc002xzl.2_Silent_p.V124V	NM_001001433	NP_001001433	O14662	STX16_HUMAN	syntaxin 16 isoform a	310	Helical; Anchor for type IV membrane protein; (Potential).				intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			ovary(1)	1	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			TATTATTTGTCATCATCATTG	0.448													0	0	0	0.00278	0	21	185										T	57251299	C	T	57251299	2	4	27	1	0	0	0	0	0	0	0	1	15338	813	29	1		1	STX16	20	57251299	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	1114751	57251299	5774221	357	7610										
COL20A1	57642	broad.mit.edu	37	chr20	61944555	61944555	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtcaccatcttggcctactaCagggacggggcccgcagtga	13	13	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr20:61944555C>T	uc011aau.1	+	17	2263	c.2163C>T	c.(2161-2163)TAC>TAT	p.Y721Y	COL20A1_uc011aav.1_Silent_p.Y542Y	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	721	Fibronectin type-III 5.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGGCCTACTACAGGGACGGGG	0.657													0	0	0	0.009096	0	3	32										T	61944555	C	T	61944555	2	4	27	1	0	0	0	0	0	0	0	1	3679	489	17	2		2	COL20A1	20	61944555	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4693256	61944555	1080965	358	7611										
CRYZL1	9946	broad.mit.edu	37	chr21	34994348	34994349	+	Frame_Shift_Ins	INS	-	-	T													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcccaacaggaaataaatccINStttttcatcttcatttctgc							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr21:34994348_34994349insT	uc011adw.1	-	4	350_351	c.170_171insA	c.(169-171)AAGfs	p.K57fs	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Frame_Shift_Ins_p.K81fs|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA|CRYZL1_uc002ysu.2_Frame_Shift_Ins_p.K57fs	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	57					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						GAAATAAATCCTTTTTCATCTT	0.327																		31	230	---	---								T	34994349	-	T	34994348	7	5	27	1	0	1	1	0	0	0	0	0	3923	680	24	0	918	0	CRYZL1	21	34994348	Frame_Shift_Ins	INS	-	TCGA-CF-A1HR-01A-11D-A13W-08		34994348	13135547	359	7612										
CLIC6	54102	broad.mit.edu	37	chr21	36088774	36088774	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tcagatgttgcaaaaagaatGaaatgaagctgggctgtttt	11	4	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr21:36088774G>A	uc010gmt.1	+	7	2109	c.2109G>A	c.(2107-2109)ATG>ATA	p.M703I	CLIC6_uc002yuf.1_Missense_Mutation_p.M685I	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	703	GST C-terminal.					chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						CAAAAAGAATGAAATGAAGCT	0.373													0	0	0	0.001168	0	6	100										A	36088774	G	A	36088774	3	1	27	1	0	0	0	0	1	0	0	0	3530	1290	45	1	2077	1	CLIC6	21	36088774	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1094426	36088774	12041121	360	7613										
PSMG1	8624	broad.mit.edu	37	chr21	40547517	40547517	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tacaaaacaatgtttaagatCatgtataaatgttactctga	5	5	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr21:40547517C>G	uc002yxi.2	-	7	995	c.866G>C	c.(865-867)TGA>TCA	p.*289S	PSMG1_uc002yxj.2_Nonstop_Mutation_p.*268S|PSMG1_uc010gob.2_Nonstop_Mutation_p.*202S	NM_003720	NP_003711	O95456	PSMG1_HUMAN	Down syndrome critical region protein 2 isoform	289					proteasome assembly	endoplasmic reticulum	protein binding				0		Prostate(19;8.44e-08)				TGTTTAAGATCATGTATAAAT	0.333											OREG0026220	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	3	77										G	40547517	C	G	40547517	4	3	27	1	0	0	0	0	0	0	0	0	12711	837	29	1	4	1	PSMG1	21	40547517	Nonstop_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4458743	40547517	7582378	361	7614										
PSMG1	8624	broad.mit.edu	37	chr21	40547542	40547542	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ataaatgttactctgaatctCatttgttgtcatcaatttct	4	7	5	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr21:40547542C>G	uc002yxi.2	-	7	970	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	PSMG1_uc002yxj.2_Missense_Mutation_p.E260Q|PSMG1_uc010gob.2_Missense_Mutation_p.E194Q	NM_003720	NP_003711	O95456	PSMG1_HUMAN	Down syndrome critical region protein 2 isoform	281					proteasome assembly	endoplasmic reticulum	protein binding				0		Prostate(19;8.44e-08)				CTCTGAATCTCATTTGTTGTC	0.368											OREG0026220	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	84										G	40547542	C	G	40547542	3	3	27	1	0	0	0	0	1	0	0	0	12711	835	29	1	29	1	PSMG1	21	40547542	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	25	40547542	7582353	362	7615										
DSCAM	1826	broad.mit.edu	37	chr21	41427661	41427661	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gggcagcttaccaatggtctCcatcgtgtctctctcttcaa	8	13	4	0			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr21:41427661C>G	uc002yyq.1	-	29	5478	c.5026G>C	c.(5026-5028)GAG>CAG	p.E1676Q	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1676	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCAATGGTCTCCATCGTGTCT	0.493													0	0	0	0.008871	0	20	68										G	41427661	C	G	41427661	3	3	27	1	0	0	0	0	1	0	0	0	4768	864	30	1	1032	1	DSCAM	21	41427661	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	880119	41427661	6702234	363	7616										
CECR2	27443	broad.mit.edu	37	chr22	18022144	18022144	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gtacctgaatcgagtacactCtgccgtctggaatgggaacc	11	11	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:18022144C>G	uc010gqw.1	+	15	2372	c.2246C>G	c.(2245-2247)TCT>TGT	p.S749C	CECR2_uc010gqv.1_Missense_Mutation_p.S608C|CECR2_uc002zml.2_Missense_Mutation_p.S608C	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	791					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CGAGTACACTCTGCCGTCTGG	0.582													0	0	0	0.001984	0	7	43										G	18022144	C	G	18022144	3	3	27	1	0	0	0	0	1	0	0	0	3206	913	32	1	2306	1	CECR2	22	18022144	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		18022144	33282422	364	7617										
SERPIND1	3053	broad.mit.edu	37	chr22	21140347	21140347	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	agaagaactacaatctagtgGagtccctgaagttgatgggg	13	6	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:21140347G>T	uc002ztb.1	+	4	1286	c.1219G>T	c.(1219-1221)GAG>TAG	p.E407*	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Nonsense_Mutation_p.E435*	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	407					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CAATCTAGTGGAGTCCCTGAA	0.483													1	0	6.31663e-08	0.003163	6.78064e-08	15	198										T	21140347	G	T	21140347	4	4	27	1	0	0	0	0	0	1	0	0	14110	1175	41	3	1229	3	SERPIND1	22	21140347	Nonsense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3118203	21140347	30164219	365	7618										
TFIP11	24144	broad.mit.edu	37	chr22	26894901	26894901	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gctggtcattctctaggaggCttttccacttagagatgatc	10	9	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:26894901C>A	uc003acr.2	-	9	1744	c.1370G>T	c.(1369-1371)AGC>ATC	p.S457I	TFIP11_uc003acs.2_Missense_Mutation_p.S457I|TFIP11_uc003act.2_Missense_Mutation_p.S457I	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	457					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCTAGGAGGCTTTTCCACTT	0.572													1	0	7.48243e-07	0.006214	7.9942e-07	10	253										A	26894901	C	A	26894901	3	1	27	1	0	0	0	0	1	0	0	0	15804	797	28	4	1167	4	TFIP11	22	26894901	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	5754554	26894901	24409665	366	7619										
SEC14L2	23541	broad.mit.edu	37	chr22	30806616	30806616	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tttcctgtggcctataacctCatcaaacccttcctgagtga	6	13	2	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:30806616C>G	uc003ahr.2	+	8	785	c.612C>G	c.(610-612)CTC>CTG	p.L204L	SEC14L2_uc003ahq.2_Silent_p.L204L|SEC14L2_uc011akx.1_Silent_p.L150L|SEC14L2_uc003ahs.2_Silent_p.L130L|SEC14L2_uc011aky.1_Silent_p.L121L|SEC14L2_uc003aht.2_RNA|SEC14L2_uc003ahu.3_Silent_p.L28L|SEC14L2_uc010gvv.2_RNA|SEC14L2_uc010gvw.1_RNA|MTP18_uc010gvx.1_5'UTR|MTP18_uc003ahv.1_Silent_p.L28L|MTP18_uc010gvy.1_Silent_p.L28L	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	204	CRAL-TRIO.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	CCTATAACCTCATCAAACCCT	0.527													0	0	0	0.009096	0	3	133										G	30806616	C	G	30806616	2	3	27	1	0	0	0	0	0	0	0	1	13982	813	29	1		1	SEC14L2	22	30806616	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	3911715	30806616	20497950	367	7620										
NAGA	4668	broad.mit.edu	37	chr22	42463826	42463827	+	In_Frame_Ins	INS	-	-	CAACTGGCATCGCGA													0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgggatccggcatcaggcggINSccactggcatcgcgaccacc							TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:42463826_42463827insCAACTGGCATCGCGA	uc003bbx.2	-	4	403_404	c.266_267insTCGCGATGCCAGTTG	c.(265-267)GGC>GGTCGCGATGCCAGTTGC	p.89_90insRDASC	NAGA_uc003bby.2_In_Frame_Ins_p.89_90insRDASC|NAGA_uc003bbw.3_In_Frame_Ins_p.89_90insRDASC	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	89_90					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						GCATCAGGCGGCCACTGGCATC	0.614																		8	185	---	---								CAACTGGCATCGCGA	42463827	-	CAACTGGCATCGCGA	42463826	7	5	27	1	0	1	1	0	0	0	0	0	10141	1190	42	0	996	0	NAGA	22	42463826	In_Frame_Ins	INS	-	TCGA-CF-A1HR-01A-11D-A13W-08	11657210	42463826	8840740	368	7621										
CYP2D6	1565	broad.mit.edu	37	chr22	42523515	42523515	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgggtcacacccagggggacGatgtccccaaagcgctgcac	13	14	1	0	rs149686350		TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:42523515G>A	uc003bce.2	-	7	1197	c.1107C>T	c.(1105-1107)ATC>ATT	p.I369I	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Silent_p.I63I|CYP2D6_uc003bcf.2_Silent_p.I318I	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	369							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						CCAGGGGGACGATGTCCCCAA	0.612													0	0	0	0.000602	0	4	41										A	42523515	G	A	42523515	2	1	27	1	0	0	0	0	0	0	0	1	4169	1048	37	1		1	CYP2D6	22	42523515	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	59689	42523515	8781051	369	7622										
C22orf9	23313	broad.mit.edu	37	chr22	45593787	45593787	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ccagggaccgtcctgtgcccGacagggaccgagaccgcagg	15	15	0	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chr22:45593787G>A	uc003bfx.1	-	9	1124	c.1058C>T	c.(1057-1059)TCG>TTG	p.S353L	C22orf9_uc010gzw.1_Missense_Mutation_p.S205L|C22orf9_uc003bfv.1_Missense_Mutation_p.S362L|C22orf9_uc003bfw.1_Missense_Mutation_p.S358L|C22orf9_uc010gzx.2_Missense_Mutation_p.S335L	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	353							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		TCCTGTGCCCGACAGGGACCG	0.607													0	0	0	0.00245	0	13	91										A	45593787	G	A	45593787	3	1	27	1	0	0	0	0	1	0	0	0	2151	1059	37	1	164	1	C22orf9	22	45593787	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	3070272	45593787	5710779	370	7623										
SYTL5	94122	broad.mit.edu	37	chrX	37955435	37955435	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tgagtcatttacagaagactCagaggatactgtaagcataa	9	6	2	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:37955435C>T	uc004ddu.2	+	10	1544	c.1010C>T	c.(1009-1011)TCA>TTA	p.S337L	SYTL5_uc004ddv.2_Missense_Mutation_p.S337L|SYTL5_uc004ddx.2_Missense_Mutation_p.S337L	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	337					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						ACAGAAGACTCAGAGGATACT	0.418													0	0	0	0.010729	0	11	57										T	37955435	C	T	37955435	3	4	27	1	0	0	0	0	1	0	0	0	15483	838	29	1	1040	1	SYTL5	23	37955435	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08		37955435	117315125	371	7624										
TFE3	7030	broad.mit.edu	37	chrX	48895743	48895743	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	tccttctctgagctggacccGatggtgagcagcgccatggg	14	12	1	2			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:48895743G>A	uc004dmb.3	-	4	997	c.759C>T	c.(757-759)ATC>ATT	p.I253I	TFE3_uc004dmc.3_Silent_p.I148I|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	253					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						AGCTGGACCCGATGGTGAGCA	0.602			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								0	0	0	0.004672	0	3	24										A	48895743	G	A	48895743	2	1	27	1	0	0	0	0	0	0	0	1	15797	1048	37	1		1	TFE3	23	48895743	Silent	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	10940308	48895743	106374817	372	7625										
CACNA1F	778	broad.mit.edu	37	chrX	49070628	49070628	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	aggggggccaccttgggcttGaaggcgatgattttgagcac	16	8	0	3			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:49070628G>C	uc004dnb.2	-	30	3794	c.3732C>G	c.(3730-3732)TTC>TTG	p.F1244L	CACNA1F_uc010nip.2_Missense_Mutation_p.F1233L	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1244	IV.|Helical; Name=S2 of repeat IV; (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CCTTGGGCTTGAAGGCGATGA	0.547													0	0	0	0.001168	0	6	55										C	49070628	G	C	49070628	3	2	27	1	0	0	0	0	1	0	0	0	2543	1281	45	1	2277	1	CACNA1F	23	49070628	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	174885	49070628	106199932	373	7626										
DOCK11	139818	broad.mit.edu	37	chrX	117788597	117788597	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	cccgcagaagtcaaagacttGaccaagagaatccgcactgt	9	12	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:117788597G>C	uc004eqp.2	+	43	4791	c.4728G>C	c.(4726-4728)TTG>TTC	p.L1576F	DOCK11_uc004eqq.2_Missense_Mutation_p.L1355F	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1576	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						TCAAAGACTTGACCAAGAGAA	0.423													0	0	0	0.004656	0	25	50										C	117788597	G	C	117788597	3	2	27	1	0	0	0	0	1	0	0	0	4686	1281	45	1	4898	1	DOCK11	23	117788597	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	68717969	117788597	37481963	374	7627										
ELF4	2000	broad.mit.edu	37	chrX	129206253	129206253	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ctttcctctctggaggccttCtcctccagagaatgcccctc	7	17	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:129206253C>T	uc004evd.3	-	5	865	c.480G>A	c.(478-480)GAG>GAA	p.E160E	ELF4_uc004eve.3_Silent_p.E160E	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	160	RUNX1-binding.				natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGAGGCCTTCTCCTCCAGAG	0.567			T	ERG	AML								0	0	0	0.013537	0	10	88										T	129206253	C	T	129206253	2	4	27	1	0	0	0	0	0	0	0	1	5056	912	32	1		1	ELF4	23	129206253	Silent	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	11417656	129206253	26064307	375	7628										
ARHGAP36	158763	broad.mit.edu	37	chrX	130220601	130220601	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	ggaaacctctgctgaagcccGggctgctgtccttgctcaaa	11	13	2	1			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:130220601G>T	uc004evz.2	+	11	1793	c.1448G>T	c.(1447-1449)CGG>CTG	p.R483L	ARHGAP36_uc004ewa.2_Missense_Mutation_p.R471L|ARHGAP36_uc004ewb.2_Missense_Mutation_p.R452L|ARHGAP36_uc004ewc.2_Missense_Mutation_p.R347L	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	483					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GCTGAAGCCCGGGCTGCTGTC	0.512													1	0	1.76056e-25	0.011902	1.92641e-25	40	26										T	130220601	G	T	130220601	3	4	27	1	0	0	0	0	1	0	0	0	883	1116	39	4	1486	4	ARHGAP36	23	130220601	Missense_Mutation	SNP	G	TCGA-CF-A1HR-01A-11D-A13W-08	1014348	130220601	25049959	376	7629										
ZNF75D	7626	broad.mit.edu	37	chrX	134421722	134421722	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.529411764705882	198	2.60363503629829e-69	3.74441289613482	4.73523940575389	3.08559108083837	0.921980682287118	0.972145733449512	145	gcatcctgatgtttgtatttCtgatgtagaaacagatatag	9	5	1	4			TCGA-CF-A1HR-01A-11D-A13W-08	TCGA-CF-A1HR-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	69acf4f1-063f-453d-b148-681518c0bc39	62d52ca4-cd68-4a07-87fb-57e5f2c09538	g.chrX:134421722C>T	uc004eyp.2	-	7	3535	c.880G>A	c.(880-882)GAA>AAA	p.E294K	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.E73K|ZNF75D_uc004eyo.2_Missense_Mutation_p.E199K	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	294	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GTTTGTATTTCTGATGTAGAA	0.373													0	0	0	0.003163	0	14	105										T	134421722	C	T	134421722	3	4	27	1	0	0	0	0	1	0	0	0	18131	922	32	1	656	1	ZNF75D	23	134421722	Missense_Mutation	SNP	C	TCGA-CF-A1HR-01A-11D-A13W-08	4201121	134421722	20848838	377	7630										
SLC2A5	6518	broad.mit.edu	37	chr1	9101954	9101954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccccccgcaggtttttagggGccagctcccctaagtacatg	10	15	0	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:9101954G>A	uc001apo.2	-	5	753	c.461C>T	c.(460-462)GCC>GTC	p.A154V	SLC2A5_uc010nzy.1_Missense_Mutation_p.A95V|SLC2A5_uc010nzz.1_Missense_Mutation_p.A39V|SLC2A5_uc010oaa.1_Missense_Mutation_p.A110V|SLC2A5_uc010oab.1_Missense_Mutation_p.A154V|SLC2A5_uc010oac.1_Silent_p.G112G|SLC2A5_uc001app.3_Missense_Mutation_p.A154V	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	154	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GTTTTTAGGGGCCAGCTCCCC	0.537													0	0	0	0.001168	0	5	16										A	9101954	G	A	9101954	3	1	28	1	0	0	0	0	1	0	0	0	14548	1203	42	2	1240	2	SLC2A5	1	9101954	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		9101954	240148667	1	7631										
TMEM54	113452	broad.mit.edu	37	chr1	33363895	33363895	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctgtcttcatcagcaccttCcggaagtcgcccacactcag	7	17	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:33363895C>G	uc001bwi.1	-	2	156	c.42G>C	c.(40-42)CGG>CGC	p.R14R	TMEM54_uc001bwj.1_Silent_p.R14R|TMEM54_uc001bwk.1_Silent_p.R14R	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	14						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCAGCACCTTCCGGAAGTCGC	0.632													0	0	0	0.001984	0	7	45										G	33363895	C	G	33363895	2	3	28	1	0	0	0	0	0	0	0	1	16177	842	30	1		1	TMEM54	1	33363895	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	24261941	33363895	215886726	2	7632										
RLF	6018	broad.mit.edu	37	chr1	40697236	40697236	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcaaagaagaattgacccttCtttagatacttttttggagc	8	7	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:40697236C>G	uc001cfc.3	+	7	1026	c.995C>G	c.(994-996)TCT>TGT	p.S332C	RLF_uc001cfd.3_Missense_Mutation_p.S23C	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	332					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			ATTGACCCTTCTTTAGATACT	0.358													0	0	0	0.010504	0	19	151										G	40697236	C	G	40697236	3	3	28	1	0	0	0	0	1	0	0	0	13389	913	32	1	1021	1	RLF	1	40697236	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7333341	40697236	208553385	3	7633										
DEM1	64789	broad.mit.edu	37	chr1	40981078	40981078	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgtcagacctcccagttattGatatcttgaagattgagtat	8	7	2	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:40981078G>T	uc001cfp.2	+	3	1067	c.862G>T	c.(862-864)GAT>TAT	p.D288Y	DEM1_uc001cfq.2_Missense_Mutation_p.D288Y|DEM1_uc001cfr.2_Missense_Mutation_p.D288Y|DEM1_uc001cfs.2_Missense_Mutation_p.D288Y	NM_022774	NP_073611	Q9H790	EXO5_HUMAN	defects in morphology 1 homolog	288							DNA binding|exonuclease activity				0						CCCAGTTATTGATATCTTGAA	0.493													1	0	1.01871e-10	0.008871	1.11764e-10	16	362										T	40981078	G	T	40981078	3	4	28	1	0	0	0	0	1	0	0	0	4425	1290	45	3	864	3	DEM1	1	40981078	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	283842	40981078	208269543	4	7634										
TIE1	7075	broad.mit.edu	37	chr1	43782984	43782984	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agtgggaggacatcacctttGaggacctcatcggggagggg	17	8	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:43782984G>C	uc001ciu.2	+	15	2603	c.2524G>C	c.(2524-2526)GAG>CAG	p.E842Q	TIE1_uc010oke.1_Missense_Mutation_p.E797Q|TIE1_uc009vwq.2_Missense_Mutation_p.E798Q|TIE1_uc010okg.1_Missense_Mutation_p.E487Q	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	842	Cytoplasmic (Potential).|Protein kinase.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CATCACCTTTGAGGACCTCAT	0.587													0	0	0	0.00499	0	14	162										C	43782984	G	C	43782984	3	2	28	1	0	0	0	0	1	0	0	0	15890	1291	45	1	2582	1	TIE1	1	43782984	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2801906	43782984	205467637	5	7635										
SLC6A9	6536	broad.mit.edu	37	chr1	44474198	44474198	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taggcccagggcagcacgtgCgtcatggacgagaagaagta	15	9	1	2	rs144161106		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:44474198C>T	uc001cll.2	-	5	828	c.636G>A	c.(634-636)ACG>ACA	p.T212T	SLC6A9_uc009vxe.2_Silent_p.T68T|SLC6A9_uc010okm.1_Silent_p.T139T|SLC6A9_uc001clm.2_Silent_p.T158T|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Silent_p.T143T|SLC6A9_uc001cln.2_Silent_p.T139T|SLC6A9_uc010oko.1_Silent_p.T28T|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	212	Extracellular (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GCAGCACGTGCGTCATGGACG	0.572													0	0	0	0.009096	0	4	114										T	44474198	C	T	44474198	2	4	28	1	0	0	0	0	0	0	0	1	14691	755	27	2		2	SLC6A9	1	44474198	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	691214	44474198	204776423	6	7636										
STIL	6491	broad.mit.edu	37	chr1	47716998	47717011	+	Frame_Shift_Del	DEL	CTTGGTTTAAGGTT	CTTGGTTTAAGGTT	-													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttcgaaggttcactgcaggaCttggtttaaggttctttact							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:47716998_47717011delCTTGGTTTAAGGTT	uc001crc.1	-	17	3816_3829	c.3661_3674delAACCTTAAACCAAG	c.(3661-3675)AACCTTAAACCAAGTfs	p.N1221fs	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Frame_Shift_Del_p.N1175fs|STIL_uc010omo.1_Frame_Shift_Del_p.N1204fs|STIL_uc001crd.1_Frame_Shift_Del_p.N1222fs|STIL_uc001cre.1_Frame_Shift_Del_p.N1221fs	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1221_1225					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				CACTGCAGGACTTGGTTTAAGGTTCTTTACTAAG	0.402																		19	335	---	---								-	47717011	CTTGGTTTAAGGTT	-	47716998	7	5	28	1	0	1	0	1	0	0	0	0	15281	565	20	0	193	0	STIL	1	47716998	Frame_Shift_Del	DEL	CTTGGTTTAAGGTT	TCGA-CF-A1HS-01A-11D-A13W-08	3242800	47716998	201533623	7	7637										
C1orf163	65260	broad.mit.edu	37	chr1	53153747	53153747	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	catcatgtgccaggaggccaAcgttgtgacatgctgctatt	11	10	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:53153747A>G	uc001cui.1	-	3	381	c.341T>C	c.(340-342)GTT>GCT	p.V114A		NM_023077	NP_075565	Q96BR5	SELR1_HUMAN	hypothetical protein LOC65260	114	Sel1-like 3.						binding				0						CAGGAGGCCAACGTTGTGACA	0.542													0	0	0	0.000602	0	5	98										G	53153747	A	G	53153747	3	3	28	1	0	0	0	0	1	0	0	0	2011	43	2	5	358	5	C1orf163	1	53153747	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	5436749	53153747	196096874	8	7638										
YIPF1	54432	broad.mit.edu	37	chr1	54343992	54343992	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcagtactaaacataccataGagatctggattgctgcggat	9	8	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:54343992G>T	uc001cvu.2	-	6	697	c.360C>A	c.(358-360)CTC>CTA	p.L120L	YIPF1_uc001cvv.2_RNA|YIPF1_uc001cvw.2_RNA|YIPF1_uc001cvx.2_RNA|YIPF1_uc001cvy.2_RNA	NM_018982	NP_061855	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1	120	Helical; (Potential).					integral to membrane|transport vesicle				large_intestine(1)|ovary(1)	2						ACATACCATAGAGATCTGGAT	0.423													1	0	1.024e-07	0.000602	1.10034e-07	5	172										T	54343992	G	T	54343992	2	4	28	1	0	0	0	0	0	0	0	1	17474	929	33	3		3	YIPF1	1	54343992	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1190245	54343992	194906629	9	7639										
PPAP2B	8613	broad.mit.edu	37	chr1	56990007	56990007	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtagttctgaatgtagccttCagagcagttgatctggctga	12	7	3	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:56990007C>T	uc001cyj.1	-	4	1018	c.517G>A	c.(517-519)GAA>AAA	p.E173K		NM_177414	NP_803133	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	173	Lumenal (Potential).				canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity				0						ATGTAGCCTTCAGAGCAGTTG	0.537													0	0	0	0.002522	0	44	132										T	56990007	C	T	56990007	3	4	28	1	0	0	0	0	1	0	0	0	12291	835	29	1	434	1	PPAP2B	1	56990007	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2646015	56990007	192260614	10	7640										
PPAP2B	8613	broad.mit.edu	37	chr1	56990203	56990203	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gacttcttcaggtaatagatCcggtagaattcccccgtgat	9	10	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:56990203C>T	uc001cyj.1	-	4	822	c.321G>A	c.(319-321)CGG>CGA	p.R107R		NM_177414	NP_803133	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	107	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity				0						GGTAATAGATCCGGTAGAATT	0.483													0	0	0	0.002299	0	20	78										T	56990203	C	T	56990203	2	4	28	1	0	0	0	0	0	0	0	1	12291	842	30	1		1	PPAP2B	1	56990203	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	196	56990203	192260418	11	7641										
DAB1	1600	broad.mit.edu	37	chr1	57480619	57480619	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caactgggagatgtcaaagtCatcacagtcgtctgtatcct	9	10	4	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:57480619C>A	uc001cys.1	-	14	2055	c.1381G>T	c.(1381-1383)GAC>TAC	p.D461Y	DAB1_uc001cyt.1_Missense_Mutation_p.D459Y|DAB1_uc001cyq.1_Missense_Mutation_p.D459Y|DAB1_uc001cyr.1_Missense_Mutation_p.D375Y|DAB1_uc009vzw.1_Missense_Mutation_p.D443Y|DAB1_uc009vzx.1_Missense_Mutation_p.D461Y	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	494					cell differentiation|nervous system development					skin(2)|ovary(1)	3						ATGTCAAAGTCATCACAGTCG	0.522													1	0	2.27111e-07	0.001368	2.41558e-07	12	69										A	57480619	C	A	57480619	3	1	28	1	0	0	0	0	1	0	0	0	4217	826	29	3	298	3	DAB1	1	57480619	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	490416	57480619	191770002	12	7642			1	25		5	5	386	C		1.754605e-11
DAB1	1600	broad.mit.edu	37	chr1	57480687	57480687	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tggagaaggcctctgaggtaCaggtgagggagggctggtcg	20	6	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:57480687C>G	uc001cys.1	-	14	1987	c.1313G>C	c.(1312-1314)TGT>TCT	p.C438S	DAB1_uc001cyt.1_Missense_Mutation_p.C436S|DAB1_uc001cyq.1_Missense_Mutation_p.C436S|DAB1_uc001cyr.1_Missense_Mutation_p.C352S|DAB1_uc009vzw.1_Missense_Mutation_p.C420S|DAB1_uc009vzx.1_Missense_Mutation_p.C438S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	471					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CTCTGAGGTACAGGTGAGGGA	0.547													0	0	0	0.004482	0	9	56										G	57480687	C	G	57480687	3	3	28	1	0	0	0	0	1	0	0	0	4217	478	17	4	366	4	DAB1	1	57480687	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	68	57480687	191769934	13	7643			1	25		5	5	386	C		1.754605e-11
DAB1	1600	broad.mit.edu	37	chr1	57480743	57480743	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acgggcggaggctgggccatCtggaaatccttaaacgtttc	13	10	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:57480743C>A	uc001cys.1	-	14	1931	c.1257G>T	c.(1255-1257)CAG>CAT	p.Q419H	DAB1_uc001cyt.1_Missense_Mutation_p.Q417H|DAB1_uc001cyq.1_Missense_Mutation_p.Q417H|DAB1_uc001cyr.1_Missense_Mutation_p.Q333H|DAB1_uc009vzw.1_Missense_Mutation_p.Q401H|DAB1_uc009vzx.1_Missense_Mutation_p.Q419H	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	452					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GCTGGGCCATCTGGAAATCCT	0.597													1	0	1.08611e-07	0.000978	1.16408e-07	12	56										A	57480743	C	A	57480743	3	1	28	1	0	0	0	0	1	0	0	0	4217	912	32	3	422	3	DAB1	1	57480743	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	56	57480743	191769878	14	7644			1	25		5	5	386	C		1.754605e-11
DAB1	1600	broad.mit.edu	37	chr1	57480856	57480856	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggcaaggggggtgaggggacCttggaacatggcagctggca	20	7	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:57480856C>T	uc001cys.1	-	14	1818	c.1144G>A	c.(1144-1146)GGT>AGT	p.G382S	DAB1_uc001cyt.1_Missense_Mutation_p.G380S|DAB1_uc001cyq.1_Missense_Mutation_p.G380S|DAB1_uc001cyr.1_Missense_Mutation_p.G296S|DAB1_uc009vzw.1_Missense_Mutation_p.G364S|DAB1_uc009vzx.1_Missense_Mutation_p.G382S	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	415					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GTGAGGGGACCTTGGAACATG	0.602													0	0	0	0.001855	0	13	55										T	57480856	C	T	57480856	3	4	28	1	0	0	0	0	1	0	0	0	4217	681	24	2	535	2	DAB1	1	57480856	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	113	57480856	191769765	15	7645			1	25		5	5	386	C		1.754605e-11
DAB1	1600	broad.mit.edu	37	chr1	57481004	57481004	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgggctgagcccccggcatCacctgagcgactggtggctg	15	13	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:57481004C>A	uc001cys.1	-	14	1670	c.996G>T	c.(994-996)GTG>GTT	p.V332V	DAB1_uc001cyt.1_Silent_p.V330V|DAB1_uc001cyq.1_Silent_p.V330V|DAB1_uc001cyr.1_Silent_p.V246V|DAB1_uc009vzw.1_Silent_p.V314V|DAB1_uc009vzx.1_Silent_p.V332V	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	365					cell differentiation|nervous system development					skin(2)|ovary(1)	3						CCCCCGGCATCACCTGAGCGA	0.667													1	0	0.00307968	0.00308	0.00314745	8	46										A	57481004	C	A	57481004	2	1	28	1	0	0	0	0	0	0	0	1	4217	813	29	3		3	DAB1	1	57481004	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	148	57481004	191769617	16	7646			1	25		5	5	386	C		1.754605e-11
LRRC7	57554	broad.mit.edu	37	chr1	70541913	70541913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctcttcacaggccacccggGgacctcagcctggacggtgc	12	17	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:70541913G>A	uc001dep.2	+	22	4300	c.4270G>A	c.(4270-4272)GGA>AGA	p.G1424R	LRRC7_uc009wbg.2_Missense_Mutation_p.G708R|LRRC7_uc001deq.2_Missense_Mutation_p.G618R	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1424						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GGCCACCCGGGGACCTCAGCC	0.468													0	0	0	0.001168	0	5	89										A	70541913	G	A	70541913	3	1	28	1	0	0	0	0	1	0	0	0	9020	1233	43	2	4356	2	LRRC7	1	70541913	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	13060909	70541913	178708708	17	7647										
ASB17	127247	broad.mit.edu	37	chr1	76397741	76397741	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taaaacttacttcaaaacggTatcctgatttttccacaaat	3	9	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:76397741T>C	uc001dhe.1	-	1	376	c.236A>G	c.(235-237)TAC>TGC	p.Y79C	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	79					intracellular signal transduction					ovary(1)	1						TTCAAAACGGTATCCTGATTT	0.378													0	0	0	0.003163	0	15	63										C	76397741	T	C	76397741	3	2	28	1	0	0	0	0	1	0	0	0	1021	1638	57	5	663	5	ASB17	1	76397741	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	5855828	76397741	172852880	18	7648										
LPHN2	23266	broad.mit.edu	37	chr1	82432119	82432119	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttggtgttcatcatttaccgGagcctgggacagttccttag	11	9	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:82432119G>A	uc001dit.3	+	12	2305	c.2124G>A	c.(2122-2124)CGG>CGA	p.R708R	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.R708R|LPHN2_uc001div.2_Silent_p.R708R|LPHN2_uc009wcd.2_Silent_p.R708R|LPHN2_uc001diw.2_Silent_p.R292R	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	721	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TCATTTACCGGAGCCTGGGAC	0.373													0	0	0	0.00278	0	23	84										A	82432119	G	A	82432119	2	1	28	1	0	0	0	0	0	0	0	1	8916	1161	41	1		1	LPHN2	1	82432119	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	6034378	82432119	166818502	19	7649										
CCDC18	343099	broad.mit.edu	37	chr1	93677790	93677790	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttaagtagtttagaaacagaAcctgtaaagctaggtggtca	10	5	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:93677790A>G	uc001dpq.2	+	11	1989	c.1821A>G	c.(1819-1821)GAA>GAG	p.E607E	CCDC18_uc009wdl.1_Silent_p.E168E	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	489										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TAGAAACAGAACCTGTAAAGC	0.289													0	0	0	0.006999	0	34	179										G	93677790	A	G	93677790	2	3	28	1	0	0	0	0	0	0	0	1	2794	40	2	5		5	CCDC18	1	93677790	Silent	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	11245671	93677790	155572831	20	7650										
COL11A1	1301	broad.mit.edu	37	chr1	103544384	103544384	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gactgaattcctttttttggTtttactgtaaatagtattga	7	4	0	2	rs150668398		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:103544384T>C	uc001dul.2	-	3	636	c.318A>G	c.(316-318)AAA>AAG	p.K106K	COL11A1_uc001dum.2_Silent_p.K106K|COL11A1_uc001dun.2_Silent_p.K106K|COL11A1_uc009weh.2_Silent_p.K106K	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	106	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTTTTTTGGTTTTACTGTAA	0.333													0	0	0	0.001368	0	13	39										C	103544384	T	C	103544384	2	2	28	1	0	0	0	0	0	0	0	1	3667	1722	60	5		5	COL11A1	1	103544384	Silent	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	9866594	103544384	145706237	21	7651										
KCND3	3752	broad.mit.edu	37	chr1	112524482	112524482	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgaagacgcggaagacccgGagcgtgacgaaggcgccgga	17	11	0	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:112524482G>C	uc001ebu.1	-	2	1347	c.867C>G	c.(865-867)CTC>CTG	p.L289L	KCND3_uc001ebv.1_Silent_p.L289L	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	289	Helical; Voltage-sensor; Name=Segment S4; (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GGAAGACCCGGAGCGTGACGA	0.602													0	0	0	0.00308	0	6	54										C	112524482	G	C	112524482	2	2	28	1	0	0	0	0	0	0	0	1	8020	1161	41	1		1	KCND3	1	112524482	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	8980098	112524482	136726139	22	7652										
TTF2	8458	broad.mit.edu	37	chr1	117640030	117640030	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taaacctgactggaggaaatCacctctttcttttggacatg	8	9	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:117640030C>A	uc001egy.2	+	21	3264	c.3244C>A	c.(3244-3246)CAC>AAC	p.H1082N		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	1082	Helicase C-terminal.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TGGAGGAAATCACCTCTTTCT	0.463													1	0	5.12918e-33	0.00361	5.73261e-33	53	249										A	117640030	C	A	117640030	3	1	28	1	0	0	0	0	1	0	0	0	16716	826	29	3	3326	3	TTF2	1	117640030	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5115548	117640030	131610591	23	7653										
PDE4DIP	9659	broad.mit.edu	37	chr1	144922578	144922578	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aattgtaccatcttgcttttGagacgactcctgagcacact	7	11	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:144922578G>C	uc001elw.3	-	7	1120	c.829C>G	c.(829-831)CAA>GAA	p.Q277E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.Q343E|PDE4DIP_uc001emc.1_Missense_Mutation_p.Q277E|PDE4DIP_uc001emd.1_Missense_Mutation_p.Q277E|PDE4DIP_uc001emb.1_Missense_Mutation_p.Q440E|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.Q64E	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	277	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCTTGCTTTTGAGACGACTCC	0.373			T	PDGFRB	MPD								0	0	0	0.00361	0	69	762										C	144922578	G	C	144922578	3	2	28	1	0	0	0	0	1	0	0	0	11643	1299	45	1	6373	1	PDE4DIP	1	144922578	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	27282548	144922578	104328043	24	7654										
SV2A	9900	broad.mit.edu	37	chr1	149879685	149879685	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcgctccccggggaacacttTggtgcgggatgcgtagtcca	15	12	0	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:149879685T>C	uc001etg.2	-	9	1944	c.1453A>G	c.(1453-1455)AAA>GAA	p.K485E	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Missense_Mutation_p.K485E	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	485	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	GGGAACACTTTGGTGCGGGAT	0.527													0	0	0	0.00361	0	50	168										C	149879685	T	C	149879685	3	2	28	1	0	0	0	0	1	0	0	0	15414	1821	63	5	795	5	SV2A	1	149879685	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	4957107	149879685	99370936	25	7655										
TARS2	80222	broad.mit.edu	37	chr1	150477198	150477198	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggagtgctggcagaaagctgCggggggaaatggtgagacct	19	6	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:150477198C>T	uc001euq.2	+	15	1816	c.1809C>T	c.(1807-1809)TGC>TGT	p.C603C	TARS2_uc001eur.2_Silent_p.C521C|TARS2_uc009wlt.2_Silent_p.C229C|TARS2_uc009wls.2_Silent_p.C473C	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	603					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CAGAAAGCTGCGGGGGGAAAT	0.567													0	0	0	0.007413	0	19	203										T	150477198	C	T	150477198	2	4	28	1	0	0	0	0	0	0	0	1	15557	776	27	2		2	TARS2	1	150477198	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	597513	150477198	98773423	26	7656										
CTSS	1520	broad.mit.edu	37	chr1	150727584	150727584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atttctctgccactggctggGaactctcagggaactcatca	9	12	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:150727584G>A	uc001evn.2	-	4	425	c.292C>T	c.(292-294)CCC>TCC	p.P98S	CTSS_uc010pcj.1_Intron|CTSS_uc001evo.1_Missense_Mutation_p.P98S	NM_004079	NP_004070	P25774	CATS_HUMAN	cathepsin S preproprotein	98					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity				0	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			CACTGGCTGGGAACTCTCAGG	0.333													0	0	0	0.00308	0	8	302										A	150727584	G	A	150727584	3	1	28	1	0	0	0	0	1	0	0	0	4041	1174	41	1	723	1	CTSS	1	150727584	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	250386	150727584	98523037	27	7657										
FAM63A	55793	broad.mit.edu	37	chr1	150973046	150973046	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaatcgcacattgacatccaGacctgtggccagtttaggca	10	11	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:150973046G>T	uc001ewf.2	-	6	2306	c.622C>A	c.(622-624)CTG>ATG	p.L208M	FAM63A_uc001ewc.2_Missense_Mutation_p.L66M|FAM63A_uc010pcm.1_Missense_Mutation_p.L113M|FAM63A_uc001ewd.2_Missense_Mutation_p.L66M|FAM63A_uc001ewe.2_Missense_Mutation_p.L42M|FAM63A_uc010pcn.1_Missense_Mutation_p.L256M|FAM63A_uc001ewg.2_Missense_Mutation_p.L208M	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	208							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTGACATCCAGACCTGTGGCC	0.493													1	0	8.60227e-14	0.004007	9.51257e-14	14	130										T	150973046	G	T	150973046	3	4	28	1	0	0	0	0	1	0	0	0	5596	933	33	3	811	3	FAM63A	1	150973046	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	245462	150973046	98277575	28	7658										
SCNM1	79005	broad.mit.edu	37	chr1	151139670	151139670	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccaaaacatcagaatgaattGagaagggaagaaaccaaagc	9	7	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:151139670G>C	uc001ewz.2	+	4	397	c.285G>C	c.(283-285)TTG>TTC	p.L95F	LYSMD1_uc001ewy.2_5'Flank|LYSMD1_uc010pcr.1_5'Flank|SCNM1_uc010pcs.1_Missense_Mutation_p.L95F|SCNM1_uc009wmn.2_RNA	NM_024041	NP_076946	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	95					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGAATGAATTGAGAAGGGAAG	0.483													0	0	0	0.004482	0	7	153										C	151139670	G	C	151139670	3	2	28	1	0	0	0	0	1	0	0	0	13926	1281	45	1	299	1	SCNM1	1	151139670	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	166624	151139670	98110951	29	7659										
SELENBP1	8991	broad.mit.edu	37	chr1	151338296	151338296	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttcttggggggcacctggatCaccttctccactgaccatgt	10	13	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:151338296C>T	uc001exx.2	-	8	917	c.870G>A	c.(868-870)GTG>GTA	p.V290V	SELENBP1_uc010pcy.1_Silent_p.V332V|SELENBP1_uc001exy.2_Silent_p.V187V|SELENBP1_uc001exz.2_Silent_p.V187V|SELENBP1_uc010pcz.1_Silent_p.V228V|SELENBP1_uc009wms.2_Silent_p.V126V|SELENBP1_uc009wmt.2_Silent_p.V187V|SELENBP1_uc001eya.2_Silent_p.V226V|SELENBP1_uc009wmu.2_Silent_p.V187V	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	290					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCACCTGGATCACCTTCTCCA	0.552													0	0	0	0.004007	0	16	219										T	151338296	C	T	151338296	2	4	28	1	0	0	0	0	0	0	0	1	14014	813	29	1		1	SELENBP1	1	151338296	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	198626	151338296	97912325	30	7660										
POGZ	23126	broad.mit.edu	37	chr1	151378787	151378787	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcagttgaggctggtgatggGagtgctggggctaagggagt	21	4	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:151378787G>A	uc001eyd.1	-	19	3030	c.2724C>T	c.(2722-2724)CTC>CTT	p.L908L	POGZ_uc001eye.1_Silent_p.L855L|POGZ_uc010pdb.1_Silent_p.L899L|POGZ_uc001eyf.1_Silent_p.L864L|POGZ_uc010pdc.1_Silent_p.L846L|POGZ_uc009wmv.1_Silent_p.L813L|POGZ_uc010pdd.1_Silent_p.L399L	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	908	Pro-rich.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTGGTGATGGGAGTGCTGGGG	0.597													0	0	0	0.003163	0	15	61										A	151378787	G	A	151378787	2	1	28	1	0	0	0	0	0	0	0	1	12186	1161	41	1		1	POGZ	1	151378787	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	40491	151378787	97871834	31	7661										
CGN	57530	broad.mit.edu	37	chr1	151506505	151506505	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aggctgagcgggacacagccCggctggacaaagagctactg	15	11	0	2	rs142498835		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:151506505C>A	uc009wmw.2	+	15	2941	c.2797C>A	c.(2797-2799)CGG>AGG	p.R933R	CGN_uc010pde.1_5'Flank	NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	927	Potential.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGACACAGCCCGGCTGGACAA	0.637													1	0	0.00909568	0.009096	0.00918356	4	50										A	151506505	C	A	151506505	2	1	28	1	0	0	0	0	0	0	0	1	3303	643	23	4		4	CGN	1	151506505	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	127718	151506505	97744116	32	7662										
RORC	6097	broad.mit.edu	37	chr1	151801935	151801935	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttctttgcagccagcagctCtgtaaagacaagagaggggg	13	9	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:151801935C>T	uc001ezh.2	-	2	149	c.41_splice	c.e2-1	p.E14_splice	RORC_uc010pdo.1_Splice_Site_p.E68_splice|RORC_uc010pdp.1_Splice_Site_p.E14_splice	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCAGCAGCTCTGTAAAGACA	0.532													0	0	0	0.00278	0	24	99										T	151801935	C	T	151801935	5	4	28	1	0	0	0	0	0	0	1	0	13530	927	32	1	1567	1	RORC	1	151801935	Splice_Site	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	295430	151801935	97448686	33	7663										
FLG	2312	broad.mit.edu	37	chr1	152281252	152281252	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctgactaccactgtaccctCggtgtccactgtctctgact	7	16	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:152281252C>T	uc001ezu.1	-	3	6146	c.6110G>A	c.(6109-6111)CGA>CAA	p.R2037Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2037	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGTACCCTCGGTGTCCACT	0.557									Ichthyosis				0	0	0	0.010504	0	20	853										T	152281252	C	T	152281252	3	4	28	1	0	0	0	0	1	0	0	0	5922	884	31	1	6079	1	FLG	1	152281252	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	479317	152281252	96969369	34	7664										
FLG	2312	broad.mit.edu	37	chr1	152287037	152287037	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgtttattatcttcatgttTatcatgatgactgtgctttc	6	7	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:152287037T>C	uc001ezu.1	-	3	361	c.325A>G	c.(325-327)AAA>GAA	p.K109E	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	109					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCATGTTTATCATGATGA	0.358									Ichthyosis				0	0	0	0.00245	0	15	253										C	152287037	T	C	152287037	3	2	28	1	0	0	0	0	1	0	0	0	5922	1763	61	5	11864	5	FLG	1	152287037	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	5785	152287037	96963584	35	7665										
LCE1F	353137	broad.mit.edu	37	chr1	152749146	152749146	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgactgctgcagccagccctCagcgggctccagctgctgcg	13	16	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:152749146C>G	uc010pdv.1	+	1	299	c.299C>G	c.(298-300)TCA>TGA	p.S100*		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	100					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCAGCCCTCAGCGGGCTCC	0.642													0	0	0	0.00308	0	6	47										G	152749146	C	G	152749146	4	3	28	1	0	0	0	0	0	1	0	0	8664	838	29	1	301	1	LCE1F	1	152749146	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	462109	152749146	96501475	36	7666										
INTS3	65123	broad.mit.edu	37	chr1	153724860	153724860	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aagatattatccataatcctCaggccttgagtcctcagttc	6	11	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:153724860C>T	uc009wom.2	+	9	1056	c.835C>T	c.(835-837)CAG>TAG	p.Q279*	INTS3_uc001fct.2_Nonsense_Mutation_p.Q279*|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_Nonsense_Mutation_p.Q73*|INTS3_uc010peb.1_Nonsense_Mutation_p.Q73*|INTS3_uc001fcw.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	280					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCATAATCCTCAGGCCTTGAG	0.433													0	0	0	0.006122	0	17	470										T	153724860	C	T	153724860	4	4	28	1	0	0	0	0	0	1	0	0	7779	827	29	1	865	1	INTS3	1	153724860	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	975714	153724860	95525761	37	7667										
PBXIP1	57326	broad.mit.edu	37	chr1	154924271	154924271	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcctaagcagggcccagtacCttctccatccatggtcccag	8	16	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:154924271C>T	uc001ffr.2	-	3	237	c.178G>A	c.(178-180)GGG>AGG	p.G60R	PBXIP1_uc001ffs.2_Missense_Mutation_p.G31R|PBXIP1_uc010pep.1_Intron|PBXIP1_uc009woy.1_RNA	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	60					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGCCCAGTACCTTCTCCATCC	0.522													0	0	0	0.000978	0	12	457										T	154924271	C	T	154924271	3	4	28	1	0	0	0	0	1	0	0	0	11496	695	24	2	2053	2	PBXIP1	1	154924271	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1199411	154924271	94326350	38	7668										
DAP3	7818	broad.mit.edu	37	chr1	155695275	155695275	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttatccagctatacgatatCttctgtgtatcctttcctgc	5	12	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:155695275C>G	uc001flq.2	+	5	542	c.373C>G	c.(373-375)CTT>GTT	p.L125V	DAP3_uc001flr.2_Missense_Mutation_p.L125V|DAP3_uc001fls.2_Missense_Mutation_p.L125V|DAP3_uc010pgl.1_Missense_Mutation_p.L84V|DAP3_uc001flt.2_Missense_Mutation_p.L91V|DAP3_uc001flu.2_Missense_Mutation_p.L125V|DAP3_uc010pgm.1_Missense_Mutation_p.L91V	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	125					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TATACGATATCTTCTGTGTAT	0.418													0	0	0	0.009535	0	25	141										G	155695275	C	G	155695275	3	3	28	1	0	0	0	0	1	0	0	0	4234	913	32	1	387	1	DAP3	1	155695275	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	771004	155695275	93555346	39	7669										
HAPLN2	60484	broad.mit.edu	37	chr1	156593922	156593922	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcatcaacggcatcgaggacGagagcgtggcgctgaccttg	14	11	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:156593922G>A	uc001fpn.1	+	4	816	c.409G>A	c.(409-411)GAG>AAG	p.E137K	HAPLN2_uc010phq.1_Missense_Mutation_p.E137K	NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	137	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CATCGAGGACGAGAGCGTGGC	0.697													0	0	0	0.009096	0	4	26										A	156593922	G	A	156593922	3	1	28	1	0	0	0	0	1	0	0	0	6955	1059	37	1	415	1	HAPLN2	1	156593922	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	898647	156593922	92656699	40	7670										
NES	10763	broad.mit.edu	37	chr1	156642464	156642464	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctctatggctgtttctttctCtaccaacccccagatttgcc	5	15	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:156642464C>G	uc001fpq.2	-	4	1649	c.1516G>C	c.(1516-1518)GAG>CAG	p.E506Q		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	506	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTTTCTTTCTCTACCAACCCC	0.502													0	0	0	0.003271	0	31	267										G	156642464	C	G	156642464	3	3	28	1	0	0	0	0	1	0	0	0	10337	922	32	1	3353	1	NES	1	156642464	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	48542	156642464	92608157	41	7671										
ALDH9A1	223	broad.mit.edu	37	chr1	165649774	165649774	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggagactttggccacatcggGatgctgacacagaaactggc	13	10	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:165649774G>A	uc001gdh.1	-	5	844	c.739C>T	c.(739-741)CCC>TCC	p.P247S	ALDH9A1_uc010pky.1_Missense_Mutation_p.P153S|ALDH9A1_uc010pkz.1_Missense_Mutation_p.P237S|ALDH9A1_uc010pla.1_Missense_Mutation_p.P153S	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	223					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	GCCACATCGGGATGCTGACAC	0.532													0	0	0	0.00623	0	39	186										A	165649774	G	A	165649774	3	1	28	1	0	0	0	0	1	0	0	0	506	1174	41	1	845	1	ALDH9A1	1	165649774	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	9007310	165649774	83600847	42	7672										
TBX19	9095	broad.mit.edu	37	chr1	168278089	168278089	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atcctgtctgtaccccacacCaacggaccaatcaatccagg	6	16	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:168278089C>G	uc001gfl.2	+	7	1077	c.1026C>G	c.(1024-1026)ACC>ACG	p.T342T	TBX19_uc001gfj.3_Silent_p.T210T|TBX19_uc001gfm.2_Silent_p.T45T	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	342					anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					TACCCCACACCAACGGACCAA	0.507													0	0	0	0.001368	0	11	156										G	168278089	C	G	168278089	2	3	28	1	0	0	0	0	0	0	0	1	15651	581	21	4		4	TBX19	1	168278089	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2628315	168278089	80972532	43	7673										
SCYL3	57147	broad.mit.edu	37	chr1	169847899	169847899	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagtgacaagatgaatgccaTccgcttccacagtacaagat	8	11	0	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:169847899T>A	uc001ggs.2	-	3	425	c.227A>T	c.(226-228)GAT>GTT	p.D76V	SCYL3_uc001ggt.2_Missense_Mutation_p.D76V|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	76	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGAATGCCATCCGCTTCCAC	0.443													0	0	0	0.00361	0	54	193										A	169847899	T	A	169847899	3	1	28	1	0	0	0	0	1	0	0	0	13949	1435	50	5	2049	5	SCYL3	1	169847899	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	1569810	169847899	79402722	44	7674										
PRG4	10216	broad.mit.edu	37	chr1	186273374	186273374	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctaagaaagttatagaatcaGaggaaataacagaaggtagg	11	3	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:186273374G>C	uc001gru.3	+	5	505	c.454G>C	c.(454-456)GAG>CAG	p.E152Q	PRG4_uc001grt.3_Missense_Mutation_p.E111Q|PRG4_uc009wyl.2_Intron|PRG4_uc009wym.2_Intron|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	152					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						TATAGAATCAGAGGAAATAAC	0.398													0	0	0	0.001168	0	6	73										C	186273374	G	C	186273374	3	2	28	1	0	0	0	0	1	0	0	0	12481	943	33	1	468	1	PRG4	1	186273374	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	16425475	186273374	62977247	45	7675										
CFHR3	10878	broad.mit.edu	37	chr1	196749062	196749062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcagaccacagttacatgtaCggagaaaggctggtctccta	11	10	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:196749062C>T	uc001gtl.2	+	3	476	c.389C>T	c.(388-390)ACG>ATG	p.T130M	CFHR3_uc001gtk.2_Missense_Mutation_p.T130M|CFHR3_uc010poy.1_Missense_Mutation_p.T130M|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	130	Sushi 2.					extracellular space					0						GTTACATGTACGGAGAAAGGC	0.473													0	0	0	0.009096	0	4	74										T	196749062	C	T	196749062	3	4	28	1	0	0	0	0	1	0	0	0	3286	536	19	2	399	2	CFHR3	1	196749062	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10475688	196749062	52501559	46	7676										
RNPEP	6051	broad.mit.edu	37	chr1	201972454	201972454	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	actcactcatgaagcctgctGaagagctagcccaactgtgg	10	12	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:201972454G>A	uc001gxd.2	+	9	1545	c.1516G>A	c.(1516-1518)GAA>AAA	p.E506K	RNPEP_uc001gxe.2_Missense_Mutation_p.E207K|RNPEP_uc001gxf.2_Missense_Mutation_p.E375K	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	506					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		GAAGCCTGCTGAAGAGCTAGC	0.582													0	0	0	0.00245	0	14	16										A	201972454	G	A	201972454	3	1	28	1	0	0	0	0	1	0	0	0	13509	1291	45	1	1550	1	RNPEP	1	201972454	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	5223392	201972454	47278167	47	7677										
ELF3	1999	broad.mit.edu	37	chr1	201981201	201981201	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caagcgccattgacttctcaCgatgtgacatggatggcgcc	11	12	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:201981201C>G	uc001gxg.3	+	2	3472	c.280C>G	c.(280-282)CGA>GGA	p.R94G	ELF3_uc001gxi.3_Missense_Mutation_p.R94G|ELF3_uc001gxh.3_Missense_Mutation_p.R94G	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	94	PNT.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						TGACTTCTCACGATGTGACAT	0.582													0	0	0	0.00308	0	7	83										G	201981201	C	G	201981201	3	3	28	1	0	0	0	0	1	0	0	0	5055	528	19	4	286	4	ELF3	1	201981201	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	8747	201981201	47269420	48	7678										
USH2A	7399	broad.mit.edu	37	chr1	215812566	215812566	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttcgtcagtcgtgcagatgaCctggaaaaagaaggctagac	12	8	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:215812566C>G	uc001hku.1	-	69	15370	c.14983G>C	c.(14983-14985)GTC>CTC	p.V4995L		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4995	Fibronectin type-III 35.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGCAGATGACCTGGAAAAAG	0.403										HNSCC(13;0.011)			0	0	0	0.001168	0	6	144										G	215812566	C	G	215812566	3	3	28	1	0	0	0	0	1	0	0	0	17033	507	18	4	641	4	USH2A	1	215812566	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	13831365	215812566	33438055	49	7679										
DISP1	84976	broad.mit.edu	37	chr1	223177617	223177617	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtgagctgagttcggcccctGaaggcctcagcaatggttgg	15	10	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:223177617G>C	uc001hnu.1	+	8	3025	c.2878G>C	c.(2878-2880)GAA>CAA	p.E960Q		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	960					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTCGGCCCCTGAAGGCCTCAG	0.507													0	0	0	0.004672	0	3	47										C	223177617	G	C	223177617	3	2	28	1	0	0	0	0	1	0	0	0	4539	1291	45	1	2904	1	DISP1	1	223177617	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	7365051	223177617	26073004	50	7680										
TLR5	7100	broad.mit.edu	37	chr1	223285979	223285979	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	catctttcaatacagcatcaGagagaccacagaaatacagt	6	10	3	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:223285979G>C	uc001hnv.1	-	4	841	c.395C>G	c.(394-396)TCT>TGT	p.S132C	TLR5_uc001hnw.1_Missense_Mutation_p.S132C	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	132	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		TACAGCATCAGAGAGACCACA	0.383													0	0	0	0.00308	0	7	91										C	223285979	G	C	223285979	3	2	28	1	0	0	0	0	1	0	0	0	15951	942	33	1	2185	1	TLR5	1	223285979	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	108362	223285979	25964642	51	7681										
SLC35F3	148641	broad.mit.edu	37	chr1	234367379	234367379	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caggaagttcgacgcgccctTcaccctcacgtggtttgcca	10	15	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:234367379T>C	uc001hwa.1	+	2	521	c.293T>C	c.(292-294)TTC>TCC	p.F98S	SLC35F3_uc001hvy.1_Missense_Mutation_p.F167S	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	98	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GACGCGCCCTTCACCCTCACG	0.587													0	0	0	0.007413	0	17	134										C	234367379	T	C	234367379	3	2	28	1	0	0	0	0	1	0	0	0	14590	1783	62	5	510	5	SLC35F3	1	234367379	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	11081400	234367379	14883242	52	7682										
CNST	163882	broad.mit.edu	37	chr1	246754982	246754982	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttctgcatcagatgaaaatGaaaatcagcttgacggggac	10	8	3	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:246754982G>C	uc001ibp.2	+	2	496	c.118G>C	c.(118-120)GAA>CAA	p.E40Q	CNST_uc001ibo.3_Missense_Mutation_p.E40Q	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	40					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						AGATGAAAATGAAAATCAGCT	0.478													0	0	0	0.004482	0	7	77										C	246754982	G	C	246754982	3	2	28	1	0	0	0	0	1	0	0	0	3634	1291	45	1	120	1	CNST	1	246754982	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	12387603	246754982	2495639	53	7683										
CNST	163882	broad.mit.edu	37	chr1	246829073	246829073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cggttttcctcagtgttggaGgaactgcattatactgcact	10	9	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:246829073G>A	uc001ibp.2	+	11	2422	c.2044G>A	c.(2044-2046)GGA>AGA	p.G682R		NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	682	Helical; (Potential).				positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						CAGTGTTGGAGGAACTGCATT	0.443													0	0	0	0.000602	0	5	100										A	246829073	G	A	246829073	3	1	28	1	0	0	0	0	1	0	0	0	3634	1001	35	2	2097	2	CNST	1	246829073	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	74091	246829073	2421548	54	7684										
OR11L1	391189	broad.mit.edu	37	chr1	248004359	248004359	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggttcagcagtggtgtgacCacagtgtagaagacagaaat	14	6	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr1:248004359C>A	uc001idn.1	-	1	840	c.840G>T	c.(838-840)GTG>GTT	p.V280V		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTGGTGTGACCACAGTGTAGA	0.443													1	0	1.9806e-07	0.002299	2.11737e-07	23	65										A	248004359	C	A	248004359	2	1	28	1	0	0	0	0	0	0	0	1	10930	581	21	4		4	OR11L1	1	248004359	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1175286	248004359	1246262	55	7685										
TPO	7173	broad.mit.edu	37	chr2	1480894	1480894	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggccggccgcgggcaccgccTgtctgcccttctaccgctct	12	19	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:1480894T>A	uc002qww.2	+	8	947	c.856T>A	c.(856-858)TGT>AGT	p.C286S	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.C286S|TPO_uc002qwr.2_Missense_Mutation_p.C286S|TPO_uc002qwx.2_Missense_Mutation_p.C286S|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.C286S	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	286	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGCACCGCCTGTCTGCCCTT	0.692													0	0	0	0.001984	0	4	7										A	1480894	T	A	1480894	3	1	28	1	0	0	0	0	1	0	0	0	16407	1580	55	5	882	5	TPO	2	1480894	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08		1480894	241718479	56	7686										
LPIN1	23175	broad.mit.edu	37	chr2	11944642	11944642	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gctgtgagggcaccatctatCtgtggaactgggatgataaa	13	7	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:11944642C>G	uc010yjn.1	+	16	2273	c.1999C>G	c.(1999-2001)CTG>GTG	p.L667V	LPIN1_uc010yjm.1_Missense_Mutation_p.L752V|LPIN1_uc002rbt.2_Missense_Mutation_p.L667V|LPIN1_uc010yjo.1_Missense_Mutation_p.L168V	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	667	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CACCATCTATCTGTGGAACTG	0.478													0	0	0	0.000978	0	11	103										G	11944642	C	G	11944642	3	3	28	1	0	0	0	0	1	0	0	0	8918	912	32	1	2053	1	LPIN1	2	11944642	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10463748	11944642	231254731	57	7687										
NCOA1	8648	broad.mit.edu	37	chr2	24929441	24929441	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtctttttccccctagggagCacagtgggctttctcctcaa	9	13	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:24929441C>T	uc002rfk.2	+	11	1360	c.1102C>T	c.(1102-1104)CAC>TAC	p.H368Y	NCOA1_uc010eye.2_Missense_Mutation_p.H368Y|NCOA1_uc002rfi.2_Missense_Mutation_p.H217Y|NCOA1_uc002rfj.2_Missense_Mutation_p.H368Y|NCOA1_uc002rfl.2_Missense_Mutation_p.H368Y	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	368	Interaction with STAT3.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTAGGGAGCACAGTGGGCT	0.378			T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.001168	0	4	63										T	24929441	C	T	24929441	3	4	28	1	0	0	0	0	1	0	0	0	10228	710	25	2	1136	2	NCOA1	2	24929441	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	12984799	24929441	218269932	58	7688										
KCNK3	3777	broad.mit.edu	37	chr2	26950989	26950989	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aacctcgtggtgctgcgcttCatgaccatgaacgccgagga	12	12	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:26950989C>T	uc002rhn.2	+	2	901	c.738C>T	c.(736-738)TTC>TTT	p.F246F		NM_002246	NP_002237	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	246	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGCTGCGCTTCATGACCATGA	0.697													0	0	0	0.001984	0	6	4										T	26950989	C	T	26950989	2	4	28	1	0	0	0	0	0	0	0	1	8067	825	29	1		1	KCNK3	2	26950989	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2021548	26950989	216248384	59	7689										
C2orf63	130162	broad.mit.edu	37	chr2	55407837	55407837	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcacatccccagcctcctcaGaaaatgtcagtctagaacaa	5	14	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:55407837G>C	uc002ryi.2	-	11	1539	c.1193C>G	c.(1192-1194)TCT>TGT	p.S398C	C2orf63_uc002ryh.2_5'UTR|C2orf63_uc002ryj.2_Missense_Mutation_p.S276C	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	398							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			AGCCTCCTCAGAAAATGTCAG	0.418													0	0	0	0.006122	0	15	73										C	55407837	G	C	55407837	3	2	28	1	0	0	0	0	1	0	0	0	2182	942	33	1	579	1	C2orf63	2	55407837	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	28456848	55407837	187791536	60	7690										
CCDC142	84865	broad.mit.edu	37	chr2	74709901	74709901	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctccccagtgcccccgggttGcgccctcagcgggggcacga	14	18	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:74709901G>C	uc002slr.2	-	1	457	c.64C>G	c.(64-66)CAA>GAA	p.Q22E	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.Q22E|CCDC142_uc002slp.2_Missense_Mutation_p.Q22E	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	22										central_nervous_system(1)	1						CCCCCGGGTTGCGCCCTCAGC	0.672													0	0	0	0.001984	0	7	63										C	74709901	G	C	74709901	3	2	28	1	0	0	0	0	1	0	0	0	2776	1328	46	4	2203	4	CCDC142	2	74709901	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	19302064	74709901	168489472	61	7691										
C2orf89	129293	broad.mit.edu	37	chr2	85097589	85097589	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tctgcgtagagccccttgccGcgctggtctggggtcatcca	13	14	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:85097589G>A	uc010ysl.1	-	2	518	c.429C>T	c.(427-429)CGC>CGT	p.R143R	C2orf89_uc002sou.3_Silent_p.R143R|C2orf89_uc010fgc.1_Silent_p.R143R	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	143	Extracellular (Potential).					integral to membrane				ovary(1)	1						GCCCCTTGCCGCGCTGGTCTG	0.582													0	0	0	0.005443	0	27	49										A	85097589	G	A	85097589	2	1	28	1	0	0	0	0	0	0	0	1	2203	1074	38	2		2	C2orf89	2	85097589	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10387688	85097589	158101784	62	7692										
C2orf89	129293	broad.mit.edu	37	chr2	85097649	85097649	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acatactccaggtggcgcttGaggcggcagtagatgtccct	13	11	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:85097649G>A	uc010ysl.1	-	2	458	c.369C>T	c.(367-369)CTC>CTT	p.L123L	C2orf89_uc002sou.3_Silent_p.L123L|C2orf89_uc010fgc.1_Silent_p.L123L	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	123	Extracellular (Potential).					integral to membrane				ovary(1)	1						GGTGGCGCTTGAGGCGGCAGT	0.572													0	0	0	0.006122	0	17	26										A	85097649	G	A	85097649	2	1	28	1	0	0	0	0	0	0	0	1	2203	1277	45	1		1	C2orf89	2	85097649	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	60	85097649	158101724	63	7693										
MRPL35	51318	broad.mit.edu	37	chr2	86437695	86437695	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aataaaacccagagtaaactCttagataaaatgacgacgtc	6	8	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:86437695C>T	uc002srg.3	+	4	529	c.471C>T	c.(469-471)CTC>CTT	p.L157L	MRPL35_uc002srf.3_Silent_p.L157L	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	157					translation	mitochondrial ribosome	structural constituent of ribosome				0						AGAGTAAACTCTTAGATAAAA	0.388													0	0	0	0.006214	0	10	104										T	86437695	C	T	86437695	2	4	28	1	0	0	0	0	0	0	0	1	9798	900	32	1		1	MRPL35	2	86437695	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1340046	86437695	156761678	64	7694										
SLC9A2	6549	broad.mit.edu	37	chr2	103318920	103318920	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagtgaaactgatgaaattCgagaactcttatcaagaaat	7	7	2	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:103318920C>G	uc002tca.2	+	9	1946	c.1804C>G	c.(1804-1806)CGA>GGA	p.R602G		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	602	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TGATGAAATTCGAGAACTCTT	0.328													0	0	0	0.001168	0	6	97										G	103318920	C	G	103318920	3	3	28	1	0	0	0	0	1	0	0	0	14712	876	31	1	1838	1	SLC9A2	2	103318920	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	16881225	103318920	139880453	65	7695										
CHCHD5	84269	broad.mit.edu	37	chr2	113343831	113343831	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagccttttgaggccttcgaGgagtgtcttcgacagaacga	12	10	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:113343831G>C	uc002thz.1	+	3	387	c.198G>C	c.(196-198)GAG>GAC	p.E66D	CHCHD5_uc002tia.2_Missense_Mutation_p.E66D	NM_032309	NP_115685	Q9BSY4	CHCH5_HUMAN	coiled-coil-helix-coiled-coil-helix domain	66	CHCH.										0						AGGCCTTCGAGGAGTGTCTTC	0.632													0	0	0	0.004672	0	3	42										C	113343831	G	C	113343831	3	2	28	1	0	0	0	0	1	0	0	0	3319	991	35	4	208	4	CHCHD5	2	113343831	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10024911	113343831	129855542	66	7696										
LIMS2	55679	broad.mit.edu	37	chr2	128412051	128412051	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agctccacatcacacagctcGcagcggaagcagcccgggtg	12	15	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:128412051G>A	uc002tpa.2	-	4	472	c.306C>T	c.(304-306)TGC>TGT	p.C102C	LIMS2_uc002tox.2_Silent_p.C126C|LIMS2_uc010fmb.2_Silent_p.C12C|LIMS2_uc002toy.2_Silent_p.C97C|LIMS2_uc010yzm.1_Silent_p.C124C|LIMS2_uc002toz.2_Silent_p.C97C|LIMS2_uc002tpb.2_Silent_p.C97C	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	102	LIM zinc-binding 2.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		CACACAGCTCGCAGCGGAAGC	0.617													0	0	0	0.002445	0	33	73										A	128412051	G	A	128412051	2	1	28	1	0	0	0	0	0	0	0	1	8804	1079	38	2		2	LIMS2	2	128412051	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	15068220	128412051	114787322	67	7697										
LY75	4065	broad.mit.edu	37	chr2	160738705	160738705	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgctgattaggtcactactGaaggctttgcatttcgcatg	10	8	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:160738705G>C	uc002ubc.3	-	7	1245	c.1176C>G	c.(1174-1176)TTC>TTG	p.F392L	LY75_uc002ubb.3_Missense_Mutation_p.F392L|LY75_uc010fos.2_Missense_Mutation_p.F392L|LY75_uc010fot.1_Missense_Mutation_p.F392L	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	392	C-type lectin 2.|Extracellular (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		GGTCACTACTGAAGGCTTTGC	0.423													0	0	0	0.004007	0	15	121										C	160738705	G	C	160738705	3	2	28	1	0	0	0	0	1	0	0	0	9099	1281	45	1	4108	1	LY75	2	160738705	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	32326654	160738705	82460668	68	7698										
GAD1	2571	broad.mit.edu	37	chr2	171709254	171709254	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtcacctggaaccctcacaaGatgatgggcgtgctgttgca	12	11	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:171709254G>C	uc002ugi.2	+	13	1637	c.1215G>C	c.(1213-1215)AAG>AAC	p.K405N	GAD1_uc010fqc.2_Missense_Mutation_p.K24N	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	405					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ACCCTCACAAGATGATGGGCG	0.507													0	0	0	0.000602	0	5	28										C	171709254	G	C	171709254	3	2	28	1	0	0	0	0	1	0	0	0	6179	933	33	1	1302	1	GAD1	2	171709254	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10970549	171709254	71490119	69	7699										
SP3	6670	broad.mit.edu	37	chr2	174819648	174819648	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gatgtagctgtataccagcaGaatctatagagttcactgta	9	7	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:174819648G>A	uc002uig.2	-	4	1756	c.1592C>T	c.(1591-1593)TCT>TTT	p.S531F	SP3_uc002uie.2_Missense_Mutation_p.S463F|SP3_uc002uif.2_Missense_Mutation_p.S478F|SP3_uc010zel.1_Missense_Mutation_p.S528F	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	531					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			TATACCAGCAGAATCTATAGA	0.433													0	0	0	0.000602	0	5	122										A	174819648	G	A	174819648	3	1	28	1	0	0	0	0	1	0	0	0	14965	942	33	1	769	1	SP3	2	174819648	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3110394	174819648	68379725	70	7700										
GPR155	151556	broad.mit.edu	37	chr2	175311382	175311382	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtaaacacagcaacacatgtCgggtcagttgctggtctcca	10	11	2	0	rs111563303		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:175311382C>T	uc002uit.2	-	13	2361	c.1970G>A	c.(1969-1971)CGA>CAA	p.R657Q	GPR155_uc002uiu.2_Missense_Mutation_p.R657Q|GPR155_uc002uiv.2_Missense_Mutation_p.R657Q|GPR155_uc010fqs.2_Missense_Mutation_p.R629Q	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	657					intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						CAACACATGTCGGGTCAGTTG	0.423													0	0	0	0.006214	0	8	125										T	175311382	C	T	175311382	3	4	28	1	0	0	0	0	1	0	0	0	6660	884	31	1	662	1	GPR155	2	175311382	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	491734	175311382	67887991	71	7701										
TTN	7273	broad.mit.edu	37	chr2	179474576	179474576	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	attgcatctcttccacctttCttcacccttagcaatcttct	2	15	5	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:179474576C>T	uc010zfg.1	-	221	44094	c.43870G>A	c.(43870-43872)GAA>AAA	p.E14624K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E8319K|TTN_uc010zfi.1_Missense_Mutation_p.E8252K|TTN_uc010zfj.1_Missense_Mutation_p.E8127K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15551							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCACCTTTCTTCACCCTTA	0.463													0	0	0	0.00361	0	50	486										T	179474576	C	T	179474576	3	4	28	1	0	0	0	0	1	0	0	0	16732	922	32	1	56483	1	TTN	2	179474576	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4163194	179474576	63724797	72	7702										
TTN	7273	broad.mit.edu	37	chr2	179629030	179629030	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aggagacacaacttctggaaCtaaagaaagaaaccacaaga	8	8	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:179629030C>G	uc010zfg.1	-	43	10213	c.9989_splice	c.e43-1	p.V3330_splice	TTN_uc010zfh.1_Splice_Site_p.V3284_splice|TTN_uc010zfi.1_Splice_Site_p.V3284_splice|TTN_uc010zfj.1_Splice_Site_p.V3284_splice|TTN_uc002umz.1_Splice_Site|TTN_uc002unb.2_Splice_Site_p.V3330_splice	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTCTGGAACTAAAGAAAGA	0.458													0	0	0	0.009096	0	4	41										G	179629030	C	G	179629030	5	3	28	1	0	0	0	0	0	0	1	0	16732	579	20	4	101280	4	TTN	2	179629030	Splice_Site	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	154454	179629030	63570343	73	7703										
ORMDL1	94101	broad.mit.edu	37	chr2	190636562	190636562	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttgggaattagtacactcagGagagaagctgtgtttaggat	13	4	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:190636562G>C	uc002urb.3	-	3	1180	c.393C>G	c.(391-393)CTC>CTG	p.L131L	ORMDL1_uc002urc.3_Silent_p.L131L|ORMDL1_uc002urd.3_Silent_p.L131L|ORMDL1_uc002ure.3_Silent_p.L131L	NM_016467	NP_057551	Q9P0S3	ORML1_HUMAN	ORM1-like 1	131					ceramide metabolic process	endoplasmic reticulum membrane|integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(117;0.00177)|Epithelial(96;0.0317)|all cancers(119;0.0889)			GTACACTCAGGAGAGAAGCTG	0.313													0	0	0	0.001855	0	13	88										C	190636562	G	C	190636562	2	2	28	1	0	0	0	0	0	0	0	1	11269	1161	41	1		1	ORMDL1	2	190636562	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	11007532	190636562	52562811	74	7704										
SGOL2	151246	broad.mit.edu	37	chr2	201436243	201436243	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaagtaataaaaaaacaaatGaacatggaatgaaaactttc	5	4	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:201436243G>C	uc002uvw.2	+	7	1287	c.1174G>C	c.(1174-1176)GAA>CAA	p.E392Q	SGOL2_uc010zhd.1_Missense_Mutation_p.E392Q|SGOL2_uc010zhe.1_Missense_Mutation_p.E392Q	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	392					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AAAAACAAATGAACATGGAAT	0.318													0	0	0	0.00308	0	8	46										C	201436243	G	C	201436243	3	2	28	1	0	0	0	0	1	0	0	0	14217	1291	45	1	1196	1	SGOL2	2	201436243	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10799681	201436243	41763130	75	7705										
BMPR2	659	broad.mit.edu	37	chr2	203420419	203420419	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaagaagttgataagaacctCaaggaaagctctgatgagaa	10	5	2	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:203420419C>G	uc002uzf.3	+	12	3179	c.2031C>G	c.(2029-2031)CTC>CTG	p.L677L	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	677	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						ATAAGAACCTCAAGGAAAGCT	0.463													0	0	0	0.006214	0	10	68										G	203420419	C	G	203420419	2	3	28	1	0	0	0	0	0	0	0	1	1471	813	29	1		1	BMPR2	2	203420419	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1984176	203420419	39778954	76	7706										
ICA1L	130026	broad.mit.edu	37	chr2	203650667	203650667	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttaatttctttggactctgtGaaggcactggctggttatca	10	7	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:203650667G>C	uc002uzh.1	-	13	1471	c.1307C>G	c.(1306-1308)TCA>TGA	p.S436*	ICA1L_uc002uzi.1_Nonsense_Mutation_p.S436*	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	436											0						TGGACTCTGTGAAGGCACTGG	0.323													0	0	0	0.00499	0	14	74										C	203650667	G	C	203650667	4	2	28	1	0	0	0	0	0	1	0	0	7478	1294	45	1	149	1	ICA1L	2	203650667	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	230248	203650667	39548706	77	7707										
CPS1	1373	broad.mit.edu	37	chr2	211481249	211481249	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttttaaacatggaaaagacaCtgaaaggcctcaacaggtaa	8	7	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:211481249C>G	uc002vee.3	+	21	2803	c.2671C>G	c.(2671-2673)CTG>GTG	p.L891V	CPS1_uc010fur.2_Missense_Mutation_p.L897V|CPS1_uc010fus.2_Missense_Mutation_p.L440V|LOC29034_uc002vef.2_5'Flank	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	891					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GGAAAAGACACTGAAAGGCCT	0.398													0	0	0	0.000602	0	4	107										G	211481249	C	G	211481249	3	3	28	1	0	0	0	0	1	0	0	0	3823	564	20	4	2775	4	CPS1	2	211481249	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7830582	211481249	31718124	78	7708										
ERBB4	2066	broad.mit.edu	37	chr2	212530179	212530179	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggccatctttaaaatgagaGcactttgtacagttgtcagg	11	7	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:212530179G>T	uc002veg.1	-	15	1838	c.1740C>A	c.(1738-1740)TGC>TGA	p.C580*	ERBB4_uc002veh.1_Nonsense_Mutation_p.C580*|ERBB4_uc010zji.1_Nonsense_Mutation_p.C580*|ERBB4_uc010zjj.1_Nonsense_Mutation_p.C580*|ERBB4_uc010fut.1_Nonsense_Mutation_p.C580*	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	580	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TAAAATGAGAGCACTTTGTAC	0.393										TSP Lung(8;0.080)			1	0	0.00307968	0.00308	0.00314745	7	59										T	212530179	G	T	212530179	4	4	28	1	0	0	0	0	0	1	0	0	5209	963	34	4	2242	4	ERBB4	2	212530179	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1048930	212530179	30669194	79	7709										
WDR69	164781	broad.mit.edu	37	chr2	228754637	228754637	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tctactcacagcttcacgaaCagagcaagtcaaacttttga	6	11	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:228754637C>T	uc002vpn.1	+	3	258	c.179C>T	c.(178-180)ACA>ATA	p.T60I	WDR69_uc010zlw.1_Missense_Mutation_p.T45I|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	60										breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		GCTTCACGAACAGAGCAAGTC	0.383													0	0	0	0.001855	0	14	56										T	228754637	C	T	228754637	3	4	28	1	0	0	0	0	1	0	0	0	17316	478	17	2	189	2	WDR69	2	228754637	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	16224458	228754637	14444736	80	7710										
DIS3L2	129563	broad.mit.edu	37	chr2	233075107	233075107	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgccctctcctgcaagccacTcgctgacggtaggatggaaa	11	13	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:233075107T>A	uc010fxz.2	+	10	1472	c.1196T>A	c.(1195-1197)CTC>CAC	p.L399H	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	399							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		TGCAAGCCACTCGCTGACGGT	0.512													0	0	0	0.004672	0	3	31										A	233075107	T	A	233075107	3	1	28	1	0	0	0	0	1	0	0	0	4537	1551	54	5	1230	5	DIS3L2	2	233075107	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	4320470	233075107	10124266	81	7711										
GPR35	2859	broad.mit.edu	37	chr2	241569480	241569480	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctggtgctaggcctgctgctCaacagcctggcgctctgggt	14	13	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr2:241569480C>G	uc002vzs.1	+	1	686	c.111C>G	c.(109-111)CTC>CTG	p.L37L	GPR35_uc010fzh.1_Silent_p.L68L|GPR35_uc010fzi.1_Silent_p.L68L	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	37	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GCCTGCTGCTCAACAGCCTGG	0.642													0	0	0	0.000602	0	5	38										G	241569480	C	G	241569480	2	3	28	1	0	0	0	0	0	0	0	1	6690	813	29	1		1	GPR35	2	241569480	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	8494373	241569480	1629893	82	7712										
CRELD1	78987	broad.mit.edu	37	chr3	9979321	9979321	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgccaccgcctgctggagctGagtgaggagctggtggagag	18	9	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:9979321G>A	uc003bug.2	+	4	451	c.333G>A	c.(331-333)CTG>CTA	p.L111L	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Silent_p.L111L|CRELD1_uc003buh.2_Silent_p.L111L|CRELD1_uc003bui.2_Silent_p.L111L|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	111	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						TGCTGGAGCTGAGTGAGGAGC	0.602													0	0	0	0.004672	0	3	10										A	9979321	G	A	9979321	2	1	28	1	0	0	0	0	0	0	0	1	3866	1277	45	1		1	CRELD1	3	9979321	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		9979321	188043109	83	7713										
VGLL4	9686	broad.mit.edu	37	chr3	11643348	11643348	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctcattttggagacgtggtcGttgtcacagtctaggtcctc	11	10	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:11643348G>C	uc003bwf.2	-	3	579	c.213C>G	c.(211-213)AAC>AAG	p.N71K	VGLL4_uc010hdx.1_Missense_Mutation_p.N77K|VGLL4_uc003bwg.2_Missense_Mutation_p.N76K|VGLL4_uc011aun.1_Missense_Mutation_p.N12K	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		AGACGTGGTCGTTGTCACAGT	0.557													0	0	0	0.001882	0	20	84										C	11643348	G	C	11643348	3	2	28	1	0	0	0	0	1	0	0	0	17158	1136	40	4	699	4	VGLL4	3	11643348	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1664027	11643348	186379082	84	7714										
XPC	7508	broad.mit.edu	37	chr3	14212042	14212042	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtgccttcttgaggtcacttGgaaagtccctgtgtaaagac	11	9	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:14212042G>T	uc011ave.1	-	3	412	c.308C>A	c.(307-309)CCA>CAA	p.P103Q	XPC_uc011avf.1_5'UTR|XPC_uc011avg.1_Missense_Mutation_p.P103Q	NM_004628	NP_004619	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	103	Glu-rich (acidic).				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			ovary(2)|breast(1)	3						GAGGTCACTTGGAAAGTCCCT	0.423			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				1	0	0.000151284	0.001855	0.000156915	11	178										T	14212042	G	T	14212042	3	4	28	1	0	0	0	0	1	0	0	0	17438	1348	47	4	1519	4	XPC	3	14212042	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2568694	14212042	183810388	85	7715										
C3orf35	339883	broad.mit.edu	37	chr3	37458815	37458815	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagaacaggcccagaatttGaaaatgtgataaagaggtta	10	6	0	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:37458815G>C	uc003cha.3	+	5	722	c.58G>C	c.(58-60)GAA>CAA	p.E20Q	C3orf35_uc003chb.2_Missense_Mutation_p.E20Q	NM_178339	NP_848029	Q8IVJ8	APRG1_HUMAN	AP20 region protein isoform B	20						integral to membrane				central_nervous_system(1)	1						CCCAGAATTTGAAAATGTGAT	0.398													0	0	0	0.001984	0	7	116										C	37458815	G	C	37458815	3	2	28	1	0	0	0	0	1	0	0	0	2225	1291	45	1	60	1	C3orf35	3	37458815	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	23246773	37458815	160563615	86	7716										
NKTR	4820	broad.mit.edu	37	chr3	42679619	42679619	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagatcatctttagattattCttcagacagtgagcagtcaa	7	8	5	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:42679619C>T	uc003clo.2	+	13	2570	c.2423C>T	c.(2422-2424)TCT>TTT	p.S808F	NKTR_uc003clm.1_Missense_Mutation_p.S555F|NKTR_uc003clp.2_Missense_Mutation_p.S555F|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.S698F|NKTR_uc003clr.1_Missense_Mutation_p.S555F|NKTR_uc003cls.2_Missense_Mutation_p.S508F	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	808	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TTAGATTATTCTTCAGACAGT	0.408													0	0	0	0.006122	0	17	78										T	42679619	C	T	42679619	3	4	28	1	0	0	0	0	1	0	0	0	10448	913	32	1	2469	1	NKTR	3	42679619	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5220804	42679619	155342811	87	7717										
KIF15	56992	broad.mit.edu	37	chr3	44846547	44846547	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggattttcacctaaagctcaGaaagagccatgtttgtttgc	9	8	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:44846547G>C	uc003cnx.3	+	15	1865	c.1716G>C	c.(1714-1716)CAG>CAC	p.Q572H	KIF15_uc010hiq.2_Missense_Mutation_p.Q475H|KIF15_uc003cny.1_Missense_Mutation_p.Q207H	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	572	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CTAAAGCTCAGAAAGAGCCAT	0.274													0	0	0	0.004007	0	15	59										C	44846547	G	C	44846547	3	2	28	1	0	0	0	0	1	0	0	0	8277	933	33	1	1774	1	KIF15	3	44846547	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2166928	44846547	153175883	88	7718										
STAB1	23166	broad.mit.edu	37	chr3	52556921	52556921	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggtgcccgcaagaacctctCagaacgctgggatgcctact	12	13	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:52556921C>T	uc003dej.2	+	62	6949	c.6875C>T	c.(6874-6876)TCA>TTA	p.S2292L	STAB1_uc003dek.1_Missense_Mutation_p.S307L|STAB1_uc003del.2_Missense_Mutation_p.S179L	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2292	Extracellular (Potential).|Link.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AAGAACCTCTCAGAACGCTGG	0.617													0	0	0	0.009096	0	4	46										T	52556921	C	T	52556921	3	4	28	1	0	0	0	0	1	0	0	0	15236	838	29	1	7121	1	STAB1	3	52556921	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7710374	52556921	145465509	89	7719										
PTPRG	5793	broad.mit.edu	37	chr3	62267314	62267314	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctttaccgtcacccttatcaGcaaagacagactgtgcctct	6	14	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:62267314G>A	uc003dlb.2	+	27	4561	c.3842G>A	c.(3841-3843)AGC>AAC	p.S1281N	PTPRG_uc003dlc.2_Missense_Mutation_p.S1252N|PTPRG_uc011bfi.1_Missense_Mutation_p.S527N|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1281	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ACCCTTATCAGCAAAGACAGA	0.403													0	0	0	0.009096	0	4	93										A	62267314	G	A	62267314	3	1	28	1	0	0	0	0	1	0	0	0	12802	971	34	2	3948	2	PTPRG	3	62267314	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	9710393	62267314	135755116	90	7720										
ADAMTS9	56999	broad.mit.edu	37	chr3	64644236	64644236	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctccatggtatgaaaccattCtgttgtctgccaccaccaag	7	13	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:64644236C>A	uc003dmg.2	-	4	943	c.911G>T	c.(910-912)AGA>ATA	p.R304I	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R304I|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R133I|ADAMTS9_uc003dmk.1_Missense_Mutation_p.R304I	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	304	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGAAACCATTCTGTTGTCTGC	0.368													1	0	1.96895e-08	0.00278	2.12119e-08	24	572										A	64644236	C	A	64644236	3	1	28	1	0	0	0	0	1	0	0	0	273	913	32	3	5040	3	ADAMTS9	3	64644236	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2376922	64644236	133378194	91	7721										
ARL6IP5	10550	broad.mit.edu	37	chr3	69153637	69153637	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgtttatccatgcatcgttGagacttcggaacctcaagaa	8	9	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:69153637G>A	uc003dnr.2	+	3	526	c.417G>A	c.(415-417)TTG>TTA	p.L139L		NM_006407	NP_006398	O75915	PRAF3_HUMAN	ADP-ribosylation-like factor 6 interacting	139	Cytoplasmic (By similarity).|Targeting to endoplasmic reticulum membrane (By similarity).				L-glutamate transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.78e-05)|Epithelial(33;0.000818)|LUSC - Lung squamous cell carcinoma(21;0.0118)|Lung(16;0.0189)|KIRC - Kidney renal clear cell carcinoma(39;0.203)|Kidney(39;0.238)		ATGCATCGTTGAGACTTCGGA	0.443													0	0	0	0.00278	0	23	759										A	69153637	G	A	69153637	2	1	28	1	0	0	0	0	0	0	0	1	944	1281	45	1		1	ARL6IP5	3	69153637	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4509401	69153637	128868793	92	7722										
CEP97	79598	broad.mit.edu	37	chr3	101481386	101481386	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tttgtacaagaagaagctttCagattcctttggaaccaggt	9	7	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:101481386C>G	uc003dvk.1	+	10	1902	c.1875C>G	c.(1873-1875)TTC>TTG	p.F625L	CEP97_uc011bhf.1_Missense_Mutation_p.F566L|CEP97_uc003dvl.1_Missense_Mutation_p.F321L|CEP97_uc003dvm.1_Missense_Mutation_p.F463L	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	625	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						AAGAAGCTTTCAGATTCCTTT	0.328													0	0	0	0.006122	0	17	123										G	101481386	C	G	101481386	3	3	28	1	0	0	0	0	1	0	0	0	3263	825	29	1	1913	1	CEP97	3	101481386	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	32327749	101481386	96541044	93	7723										
CD200	4345	broad.mit.edu	37	chr3	112054854	112054854	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctaggaaagaccaccatcaAtgattaccaggtaattttct	6	10	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:112054854A>G	uc003dyw.2	+	2	221	c.77A>G	c.(76-78)AAT>AGT	p.N26S	CD200_uc010hqd.1_Intron|CD200_uc003dyx.2_Intron|CD200_uc003dyy.2_Intron|CD200_uc003dyz.2_Intron	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	Error:Variant_position_missing_in_P41217_after_alignment					regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				ACCACCATCAATGATTACCAG	0.338													0	0	0	0.002836	0	33	68										G	112054854	A	G	112054854	3	3	28	1	0	0	0	0	1	0	0	0	2980	101	4	5	83	5	CD200	3	112054854	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	10573468	112054854	85967576	94	7724										
C3orf1	51300	broad.mit.edu	37	chr3	119217621	119217621	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	accgcggagctttctctgtaGagcattgtgcctatttcccc	9	13	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:119217621G>A	uc003ecn.2	+	1	254	c.41G>A	c.(40-42)AGA>AAA	p.R14K	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_5'Flank	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	14						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		TTTCTCTGTAGAGCATTGTGC	0.592													0	0	0	0.009535	0	27	196										A	119217621	G	A	119217621	3	1	28	1	0	0	0	0	1	0	0	0	2206	942	33	1	43	1	C3orf1	3	119217621	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	7162767	119217621	78804809	95	7725										
GOLGB1	2804	broad.mit.edu	37	chr3	121410632	121410632	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttggcattctcagaattgaGatcatccatatgacttctca	6	10	3	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:121410632G>C	uc003eei.3	-	14	7690	c.7564C>G	c.(7564-7566)CTC>GTC	p.L2522V	GOLGB1_uc010hrc.2_Missense_Mutation_p.L2527V|GOLGB1_uc003eej.3_Missense_Mutation_p.L2488V	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2522	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCAGAATTGAGATCATCCATA	0.393													0	0	0	0.004482	0	9	357										C	121410632	G	C	121410632	3	2	28	1	0	0	0	0	1	0	0	0	6565	942	33	1	2251	1	GOLGB1	3	121410632	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2193011	121410632	76611798	96	7726										
MYLK	4638	broad.mit.edu	37	chr3	123452592	123452592	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcctggctttggggcttgctCtcaaatttggggaatgctga	13	8	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:123452592C>G	uc003ego.2	-	10	1533	c.1251G>C	c.(1249-1251)GAG>GAC	p.E417D	MYLK_uc011bjw.1_Missense_Mutation_p.E417D|MYLK_uc003egp.2_Missense_Mutation_p.E417D|MYLK_uc003egq.2_Missense_Mutation_p.E417D|MYLK_uc003egr.2_Missense_Mutation_p.E417D|MYLK_uc003egs.2_Missense_Mutation_p.E241D	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	417	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GGGGCTTGCTCTCAAATTTGG	0.517													0	0	0	0.001368	0	12	143										G	123452592	C	G	123452592	3	3	28	1	0	0	0	0	1	0	0	0	10056	912	32	1	4593	1	MYLK	3	123452592	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2041960	123452592	74569838	97	7727										
ZBTB38	253461	broad.mit.edu	37	chr3	141162247	141162247	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagccgcagaggttccaccTctggtgtacaattgtagctg	11	12	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:141162247T>G	uc003etw.2	+	8	1999	c.1017T>G	c.(1015-1017)CCT>CCG	p.P339P	ZBTB38_uc010hun.2_Silent_p.P336P|ZBTB38_uc010huo.2_Silent_p.P339P|ZBTB38_uc003ety.2_Silent_p.P339P|ZBTB38_uc010hup.2_Silent_p.P340P	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	339					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AGGTTCCACCTCTGGTGTACA	0.498													0	0	0	0.004482	0	7	137										G	141162247	T	G	141162247	2	3	28	1	0	0	0	0	0	0	0	1	17536	1538	54	5		5	ZBTB38	3	141162247	Silent	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	17709655	141162247	56860183	98	7728										
GMPS	8833	broad.mit.edu	37	chr3	155632331	155632331	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cacaagtcctgaagagaaaaGaaaaatcattggggatactt	9	6	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:155632331G>C	uc003faq.2	+	8	1345	c.1010G>C	c.(1009-1011)AGA>ACA	p.R337T	GMPS_uc011bom.1_Missense_Mutation_p.R238T	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	337					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GAAGAGAAAAGAAAAATCATT	0.328			T	MLL	AML								0	0	0	0.006214	0	8	92										C	155632331	G	C	155632331	3	2	28	1	0	0	0	0	1	0	0	0	6498	942	33	1	1040	1	GMPS	3	155632331	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	14470084	155632331	42390099	99	7729										
KCNAB1	7881	broad.mit.edu	37	chr3	156232888	156232888	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgtaatctcattcctccctaGgaagcctattctgtagcaag	7	11	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:156232888G>T	uc003far.2	+	10	809	c.745_splice	c.e10-1	p.E249_splice	KCNAB1_uc011bon.1_Splice_Site_p.E220_splice|KCNAB1_uc003fas.2_Splice_Site_p.E238_splice|KCNAB1_uc003fat.2_Splice_Site_p.E231_splice|KCNAB1_uc010hvt.1_Splice_Site_p.E202_splice|KCNAB1_uc011boo.1_Splice_Site_p.E125_splice	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related							cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TTCCTCCCTAGGAAGCCTATT	0.413													1	0	1.33987e-11	0.008291	1.47775e-11	11	127										T	156232888	G	T	156232888	5	4	28	1	0	0	0	0	0	0	1	0	8009	1014	35	4	1253	4	KCNAB1	3	156232888	Splice_Site	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	600557	156232888	41789542	100	7730										
SKIL	6498	broad.mit.edu	37	chr3	170078501	170078501	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttctgcctcttccatcacctCaggttcttcctggcccattg	6	16	5	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:170078501C>G	uc003fgu.2	+	2	1094	c.382C>G	c.(382-384)CAG>GAG	p.Q128E	SKIL_uc011bps.1_Missense_Mutation_p.Q108E|SKIL_uc003fgv.2_Missense_Mutation_p.Q128E|SKIL_uc003fgw.2_Missense_Mutation_p.Q128E	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	128					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TCCATCACCTCAGGTTCTTCC	0.488													0	0	0	0.005443	0	27	353										G	170078501	C	G	170078501	3	3	28	1	0	0	0	0	1	0	0	0	14358	827	29	1	384	1	SKIL	3	170078501	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	13845613	170078501	27943929	101	7731										
MCF2L2	23101	broad.mit.edu	37	chr3	183013209	183013209	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttcatcagactcacttgcctCttgtgaaatatttcctggac	6	11	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:183013209C>G	uc003fli.1	-	13	1644	c.1554G>C	c.(1552-1554)AAG>AAC	p.K518N	MCF2L2_uc003flj.1_Missense_Mutation_p.K518N|MCF2L2_uc011bqr.1_RNA|uc003fln.1_Intron|uc003flo.2_5'Flank	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	518					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TCACTTGCCTCTTGTGAAATA	0.458													0	0	0	0.000602	0	4	99										G	183013209	C	G	183013209	3	3	28	1	0	0	0	0	1	0	0	0	9380	912	32	1	1862	1	MCF2L2	3	183013209	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	12934708	183013209	15009221	102	7732										
MAGEF1	64110	broad.mit.edu	37	chr3	184429334	184429334	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cgtgtgatgggactcttcttCttgtctttcaccaggaggaa	11	9	5	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:184429334C>T	uc003fpa.2	-	1	503	c.276G>A	c.(274-276)AAG>AAA	p.K92K		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	92	MAGE.									ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			GACTCTTCTTCTTGTCTTTCA	0.582													0	0	0	0.001168	0	5	176										T	184429334	C	T	184429334	2	4	28	1	0	0	0	0	0	0	0	1	9187	912	32	1		1	MAGEF1	3	184429334	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1416125	184429334	13593096	103	7733										
ATP13A5	344905	broad.mit.edu	37	chr3	193029620	193029620	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttacttttggaagcaagctGttgaaatgctgaaatatcac	8	7	1	2	rs112958471		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:193029620G>A	uc011bsq.1	-	20	2430	c.2430C>T	c.(2428-2430)AAC>AAT	p.N810N		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	810					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GAAGCAAGCTGTTGAAATGCT	0.423													0	0	0	0.001855	0	13	79										A	193029620	G	A	193029620	2	1	28	1	0	0	0	0	0	0	0	1	1127	1368	48	2		2	ATP13A5	3	193029620	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	8600286	193029620	4992810	104	7734										
ATP13A3	79572	broad.mit.edu	37	chr3	194176633	194176633	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tagtcttacctctttaattaGaagcttaaaaacagaaggca	6	7	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr3:194176633G>C	uc003fty.3	-	7	1021	c.619C>G	c.(619-621)CTA>GTA	p.L207V		NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	207	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TCTTTAATTAGAAGCTTAAAA	0.274													0	0	0	0.004482	0	7	197										C	194176633	G	C	194176633	3	2	28	1	0	0	0	0	1	0	0	0	1125	933	33	1	3165	1	ATP13A3	3	194176633	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1147013	194176633	3845797	105	7735										
WFS1	7466	broad.mit.edu	37	chr4	6303952	6303952	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgcgggccagcagcgagttCaagagcgtgctgctcagcct	14	13	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:6303952C>A	uc003giy.2	+	8	2596	c.2430C>A	c.(2428-2430)TTC>TTA	p.F810L	WFS1_uc003gix.2_Missense_Mutation_p.F810L|WFS1_uc003giz.2_Missense_Mutation_p.F628L	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	810					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GCAGCGAGTTCAAGAGCGTGC	0.662													1	0	0.00909568	0.009096	0.00918356	4	18										A	6303952	C	A	6303952	3	1	28	1	0	0	0	0	1	0	0	0	17357	825	29	3	2456	3	WFS1	4	6303952	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08		6303952	184850324	106	7736										
ADAMTS3	9508	broad.mit.edu	37	chr4	73169735	73169735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	accaagatctatgaaggtccGcgacttggcttcctcccctt	8	14	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:73169735G>A	uc003hgk.1	-	17	2360	c.2323C>T	c.(2323-2325)CGG>TGG	p.R775W	ADAMTS3_uc003hgl.2_Missense_Mutation_p.R116W	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	775	Spacer.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ATGAAGGTCCGCGACTTGGCT	0.393													0	0	0	0.00361	0	92	161										A	73169735	G	A	73169735	3	1	28	1	0	0	0	0	1	0	0	0	267	1086	38	2	1318	2	ADAMTS3	4	73169735	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	66865783	73169735	117984541	107	7737										
AFF1	4299	broad.mit.edu	37	chr4	88012958	88012958	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tttctaggactctcagcatgTcagttctgtaacccaaaacc	6	12	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:88012958T>A	uc003hqj.3	+	6	1591	c.1184T>A	c.(1183-1185)GTC>GAC	p.V395D	AFF1_uc003hqh.1_Missense_Mutation_p.V401D|AFF1_uc011ccy.1_Missense_Mutation_p.V373D|AFF1_uc011ccz.1_Missense_Mutation_p.V402D|AFF1_uc003hqk.3_Missense_Mutation_p.V395D|AFF1_uc011cda.1_Missense_Mutation_p.V33D	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	395						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCTCAGCATGTCAGTTCTGTA	0.284													0	0	0	0.001168	0	6	9										A	88012958	T	A	88012958	3	1	28	1	0	0	0	0	1	0	0	0	356	1667	58	5	1248	5	AFF1	4	88012958	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	14843223	88012958	103141318	108	7738										
SYNPO2	171024	broad.mit.edu	37	chr4	119979019	119979019	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	catgtccatggaaaccaggtCtgattactgtcttccagtag	9	10	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:119979019C>G	uc010inb.2	+	5	3912	c.3716C>G	c.(3715-3717)TCT>TGT	p.S1239C	SYNPO2_uc011cgh.1_3'UTR|SYNPO2_uc010inc.2_Missense_Mutation_p.S1109C	NM_133477	NP_597734	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform a	Error:Variant_position_missing_in_Q9UMS6_after_alignment						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						GAAACCAGGTCTGATTACTGT	0.443													0	0	0	0.001168	0	6	58										G	119979019	C	G	119979019	3	3	28	1	0	0	0	0	1	0	0	0	15454	913	32	1	3846	1	SYNPO2	4	119979019	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	31966061	119979019	71175257	109	7739										
ZNF827	152485	broad.mit.edu	37	chr4	146686170	146686170	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cggtggggacagtgtggcatTtcttatgctccagcagctgt	14	9	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:146686170T>G	uc003ikn.2	-	13	3248	c.3200A>C	c.(3199-3201)AAA>ACA	p.K1067T	ZNF827_uc003ikm.2_Missense_Mutation_p.K1067T|ZNF827_uc010iox.2_Missense_Mutation_p.K717T|ZNF827_uc003ikl.2_Missense_Mutation_p.K152T	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	1067	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					AGTGTGGCATTTCTTATGCTC	0.498													0	0	0	0.001984	0	5	133										G	146686170	T	G	146686170	3	3	28	1	0	0	0	0	1	0	0	0	18177	1841	64	5	37	5	ZNF827	4	146686170	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	26707151	146686170	44468106	110	7740										
NPY2R	4887	broad.mit.edu	37	chr4	156136153	156136153	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gccattcactctgaggtgtcCgtgacattcaaggctaaaaa	9	10	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:156136153C>A	uc003ioq.2	+	2	1557	c.1062C>A	c.(1060-1062)TCC>TCA	p.S354S	NPY2R_uc003ior.2_Silent_p.S354S	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	354	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CTGAGGTGTCCGTGACATTCA	0.507													1	0	1.33834e-09	0.007413	1.44929e-09	18	75										A	156136153	C	A	156136153	2	1	28	1	0	0	0	0	0	0	0	1	10609	639	23	4		4	NPY2R	4	156136153	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	9449983	156136153	35018123	111	7741										
NEIL3	55247	broad.mit.edu	37	chr4	178281777	178281777	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaggatggggaaaacaagggCaggcagttttatgcctgtcc	14	7	0	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr4:178281777C>T	uc003iut.2	+	9	1698	c.1581C>T	c.(1579-1581)GGC>GGT	p.G527G		NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	527					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		AAAACAAGGGCAGGCAGTTTT	0.443								BER_DNA_glycosylases					0	0	0	0.001168	0	6	102										T	178281777	C	T	178281777	2	4	28	1	0	0	0	0	0	0	0	1	10320	697	25	2		2	NEIL3	4	178281777	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	22145624	178281777	12872499	112	7742										
EXOC3	11336	broad.mit.edu	37	chr5	462321	462321	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atttaaagaatgaagtggaaGagggtgtgtctccgagccag	14	5	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:462321G>T	uc003jba.2	+	9	1680	c.1552G>T	c.(1552-1554)GAG>TAG	p.E518*		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	529					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TGAAGTGGAAGAGGGTGTGTC	0.547													1	0	1.61879e-10	0.001368	1.77135e-10	12	249										T	462321	G	T	462321	4	4	28	1	0	0	0	0	0	1	0	0	5303	943	33	3	1582	3	EXOC3	5	462321	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		462321	180452939	113	7743										
SLC9A3	6550	broad.mit.edu	37	chr5	476396	476396	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagcttggtcgacttgaagGactccaggcgcttccgcatg	12	13	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:476396G>T	uc003jbe.2	-	13	2100	c.1988C>A	c.(1987-1989)TCC>TAC	p.S663Y	SLC9A3_uc011clx.1_Missense_Mutation_p.S654Y|uc011cly.1_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	663	Interaction with PDZD3 (By similarity).|Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGACTTGAAGGACTCCAGGCG	0.602													1	0	2.17888e-05	0.006214	2.27693e-05	9	240										T	476396	G	T	476396	3	4	28	1	0	0	0	0	1	0	0	0	14713	1174	41	3	536	3	SLC9A3	5	476396	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	14075	476396	180438864	114	7744										
CDH6	1004	broad.mit.edu	37	chr5	31317512	31317512	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccctgcatgctgttgacaagGatgacccttatagtggacac	10	11	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:31317512G>C	uc003jhe.1	+	10	1869	c.1543G>C	c.(1543-1545)GAT>CAT	p.D515H	CDH6_uc003jhd.1_Missense_Mutation_p.D515H	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	515	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGTTGACAAGGATGACCCTTA	0.398													0	0	0	0.002299	0	20	246										C	31317512	G	C	31317512	3	2	28	1	0	0	0	0	1	0	0	0	3114	1174	41	1	1577	1	CDH6	5	31317512	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	30841116	31317512	149597748	115	7745										
SPEF2	79925	broad.mit.edu	37	chr5	35753786	35753786	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aggaagaggcggagcaggagCggcttgacatcattaatgag	16	6	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:35753786C>T	uc003jjo.2	+	24	3502	c.3391C>T	c.(3391-3393)CGG>TGG	p.R1131W	SPEF2_uc003jjp.1_Missense_Mutation_p.R617W	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1131					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAGCAGGAGCGGCTTGACAT	0.483													0	0	0	0.003163	0	10	377										T	35753786	C	T	35753786	3	4	28	1	0	0	0	0	1	0	0	0	15034	759	27	2	3506	2	SPEF2	5	35753786	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4436274	35753786	145161474	116	7746										
CAPSL	133690	broad.mit.edu	37	chr5	35910144	35910144	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taactttctaaaagcttgcaTgattacctcttttctggctc	5	10	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:35910144T>A	uc003jjt.1	-	4	444	c.349A>T	c.(349-351)ATG>TTG	p.M117L	CAPSL_uc003jju.1_Missense_Mutation_p.M117L	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	117	EF-hand 3.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			AAAGCTTGCATGATTACCTCT	0.373													0	0	0	0.001882	0	21	290										A	35910144	T	A	35910144	3	1	28	1	0	0	0	0	1	0	0	0	2639	1464	51	5	285	5	CAPSL	5	35910144	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	156358	35910144	145005116	117	7747										
PAIP1	10605	broad.mit.edu	37	chr5	43547975	43547975	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaaaatcctgaacatattctGatagagtaggataatcctca	6	7	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:43547975G>C	uc003job.2	-	3	723	c.476C>G	c.(475-477)TCA>TGA	p.S159*	PAIP1_uc003joa.2_Nonsense_Mutation_p.S80*|PAIP1_uc010ivp.2_Nonsense_Mutation_p.S80*|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Nonsense_Mutation_p.S47*	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	159	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					AACATATTCTGATAGAGTAGG	0.368													0	0	0	0.003163	0	14	175										C	43547975	G	C	43547975	4	2	28	1	0	0	0	0	0	1	0	0	11396	1294	45	1	999	1	PAIP1	5	43547975	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	7637831	43547975	137367285	118	7748										
BDP1	55814	broad.mit.edu	37	chr5	70786810	70786810	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acatgcattttgtatttgtaGataaatgtcaggctataagg	9	4	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:70786810G>C	uc003kbp.1	+	11	1756	c.1493_splice	c.e11-1	p.N498_splice	BDP1_uc003kbn.1_Splice_Site_p.N498_splice|BDP1_uc003kbo.2_Splice_Site_p.N498_splice	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator						regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TGTATTTGTAGATAAATGTCA	0.363													0	0	0	0.001368	0	12	42										C	70786810	G	C	70786810	5	2	28	1	0	0	0	0	0	0	1	0	1395	956	33	1	1534	1	BDP1	5	70786810	Splice_Site	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	27238835	70786810	110128450	119	7749										
PCSK1	5122	broad.mit.edu	37	chr5	95743998	95743998	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaggtgcctgtgtgcgtctcCgtgcagtcattgtgcaggtc	15	10	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:95743998C>G	uc003kls.1	-	9	1331	c.1125G>C	c.(1123-1125)ACG>ACC	p.T375T	PCSK1_uc010jbi.1_Silent_p.T65T	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	375	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGTGCGTCTCCGTGCAGTCAT	0.577													0	0	0	0.001984	0	6	20										G	95743998	C	G	95743998	2	3	28	1	0	0	0	0	0	0	0	1	11600	639	23	4		4	PCSK1	5	95743998	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	24957188	95743998	85171262	120	7750										
MCC	4163	broad.mit.edu	37	chr5	112421001	112421001	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgtagtcgagtttgaagctCtctgacctgaaatcataatg	9	8	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:112421001C>T	uc003kqj.3	-	7	1365	c.835G>A	c.(835-837)GAG>AAG	p.E279K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E469K|MCC_uc011cwb.1_Missense_Mutation_p.E279K|MCC_uc010jcd.1_Missense_Mutation_p.E241K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	279					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GTTTGAAGCTCTCTGACCTGA	0.532													0	0	0	0.003954	0	27	103										T	112421001	C	T	112421001	3	4	28	1	0	0	0	0	1	0	0	0	9373	922	32	1	1698	1	MCC	5	112421001	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	16677003	112421001	68494259	121	7751										
MRPL22	29093	broad.mit.edu	37	chr5	154346442	154346442	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagcttcgcagccggaccatCgttcacactctatgatgagg	10	13	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:154346442C>T	uc003lvy.3	+	7	644	c.606C>T	c.(604-606)ATC>ATT	p.I202I	MRPL22_uc003lvz.3_Silent_p.I122I	NM_014180	NP_054899	Q9NWU5	RM22_HUMAN	mitochondrial ribosomal protein L22 isoform a	202					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCCGGACCATCGTTCACACTC	0.438													0	0	0	0.009096	0	4	20										T	154346442	C	T	154346442	2	4	28	1	0	0	0	0	0	0	0	1	9788	874	31	1		1	MRPL22	5	154346442	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	41925441	154346442	26568818	122	7752										
MED7	9443	broad.mit.edu	37	chr5	156565803	156565803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agcatctttctctataatctGatctctcctatgacctgaat	4	11	4	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:156565803G>C	uc010jik.2	-	2	1032	c.640C>G	c.(640-642)CAG>GAG	p.Q214E	MED7_uc003lwm.3_Missense_Mutation_p.Q214E	NM_001100816	NP_001094286	O43513	MED7_HUMAN	mediator complex subunit 7	214					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity				0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTATAATCTGATCTCTCCTA	0.348													0	0	0	0.003214	0	43	223										C	156565803	G	C	156565803	3	2	28	1	0	0	0	0	1	0	0	0	9452	1299	45	1	65	1	MED7	5	156565803	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2219361	156565803	24349457	123	7753										
STK10	6793	broad.mit.edu	37	chr5	171523528	171523528	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctcagccaccagctcccgcaGagccttgttactggtgatgc	10	15	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:171523528G>T	uc003mbo.1	-	8	1207	c.907C>A	c.(907-909)CTG>ATG	p.L303M		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	303							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGCTCCCGCAGAGCCTTGTTA	0.627													1	0	0.00198382	0.001984	0.00203743	6	124										T	171523528	G	T	171523528	3	4	28	1	0	0	0	0	1	0	0	0	15285	933	33	3	2047	3	STK10	5	171523528	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	14957725	171523528	9391732	124	7754										
HK3	3101	broad.mit.edu	37	chr5	176323070	176323070	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagtgctgaacttaccagctCtgagctgtctgagggcccgg	13	12	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:176323070C>T	uc003mfa.2	-	2	183	c.91G>A	c.(91-93)GAG>AAG	p.E31K		NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	31	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTACCAGCTCTGAGCTGTCT	0.587													0	0	0	0.006122	0	19	57										T	176323070	C	T	176323070	3	4	28	1	0	0	0	0	1	0	0	0	7192	922	32	1	2752	1	HK3	5	176323070	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4799542	176323070	4592190	125	7755										
ZNF354C	30832	broad.mit.edu	37	chr5	178506306	178506306	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcaacccttatcaaacatctGagagtgcatactggagagaa	8	9	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:178506306G>C	uc003mju.2	+	5	988	c.873G>C	c.(871-873)CTG>CTC	p.L291L		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	291	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TCAAACATCTGAGAGTGCATA	0.418													0	0	0	0.00361	0	62	97										C	178506306	G	C	178506306	2	2	28	1	0	0	0	0	0	0	0	1	17863	1277	45	1		1	ZNF354C	5	178506306	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2183236	178506306	2408954	126	7756										
TBC1D9B	23061	broad.mit.edu	37	chr5	179292339	179292339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaaggtagtgccgatagtccGgagagctggtccccttctcc	13	12	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr5:179292339G>A	uc003mlh.2	-	21	3024	c.2987C>T	c.(2986-2988)CCG>CTG	p.P996L	TBC1D9B_uc003mli.2_Missense_Mutation_p.P979L|TBC1D9B_uc003mlj.2_Missense_Mutation_p.P978L|TBC1D9B_uc003mlf.2_Missense_Mutation_p.P70L|TBC1D9B_uc003mlg.2_Missense_Mutation_p.P155L|TBC1D9B_uc011dgv.1_Missense_Mutation_p.P155L	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	996						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGATAGTCCGGAGAGCTGGT	0.537													0	0	0	0.006214	0	7	118										A	179292339	G	A	179292339	3	1	28	1	0	0	0	0	1	0	0	0	15625	1116	39	2	773	2	TBC1D9B	5	179292339	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	786033	179292339	1622921	127	7757										
KIF13A	63971	broad.mit.edu	37	chr6	17987315	17987315	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtttggtgttagaaggaggaGggtgcaggaccgtttgattc	17	4	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:17987315G>C	uc003ncg.3	-	2	221	c.116C>G	c.(115-117)CCT>CGT	p.P39R	KIF13A_uc003ncf.2_Missense_Mutation_p.P39R|KIF13A_uc003nch.3_Missense_Mutation_p.P39R|KIF13A_uc003nci.3_Missense_Mutation_p.P39R|KIF13A_uc003nck.2_RNA	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	39	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			AGAAGGAGGAGGGTGCAGGAC	0.562													0	0	0	0.008291	0	9	123										C	17987315	G	C	17987315	3	2	28	1	0	0	0	0	1	0	0	0	8274	1000	35	4	5478	4	KIF13A	6	17987315	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		17987315	153127752	128	7758										
ZSCAN16	80345	broad.mit.edu	37	chr6	28093491	28093491	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctggtgctagaacagttcctGagcattcttcctaaagacct	8	11	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:28093491G>C	uc003nkm.2	+	2	370	c.270G>C	c.(268-270)CTG>CTC	p.L90L	uc010jqw.1_Intron|uc003nkk.1_RNA|uc003nkl.1_Intron|ZSCAN16_uc011dky.1_Silent_p.L90L	NM_025231	NP_079507	Q9H4T2	ZSC16_HUMAN	zinc finger and SCAN domain containing 16	90	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)	1						AACAGTTCCTGAGCATTCTTC	0.522													0	0	0	0.00308	0	8	91										C	28093491	G	C	28093491	2	2	28	1	0	0	0	0	0	0	0	1	18226	1277	45	1		1	ZSCAN16	6	28093491	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10106176	28093491	143021576	129	7759										
TNXB	7148	broad.mit.edu	37	chr6	32014187	32014187	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gagctggaggtctcctcagcCacggtcagttcccccaggtg	13	14	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:32014187C>T	uc003nzl.2	-	31	10567	c.10365G>A	c.(10363-10365)GTG>GTA	p.V3455V	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'UTR	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3502	Fibronectin type-III 27.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCCTCAGCCACGGTCAGTT	0.632													0	0	0	0.004482	0	7	20										T	32014187	C	T	32014187	2	4	28	1	0	0	0	0	0	0	0	1	16343	581	21	2		2	TNXB	6	32014187	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	3920696	32014187	139100880	130	7760										
PPT2	9374	broad.mit.edu	37	chr6	32130348	32130348	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cccaaatctctttgtagcttCtttggtttctatgatgcaaa	6	9	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:32130348C>G	uc003nzx.2	+	8	1282	c.714C>G	c.(712-714)TTC>TTG	p.F238L	PPT2_uc003nzw.2_Missense_Mutation_p.F244L|PPT2_uc011dpi.1_RNA|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Missense_Mutation_p.F238L|PPT2_uc003oaa.2_Missense_Mutation_p.F238L|PPT2_uc010jtu.1_Missense_Mutation_p.F238L|EGFL8_uc003oac.1_5'Flank|EGFL8_uc003oab.1_5'Flank	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	238					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						TTTGTAGCTTCTTTGGTTTCT	0.373													0	0	0	0.00361	0	71	234										G	32130348	C	G	32130348	3	3	28	1	0	0	0	0	1	0	0	0	12412	912	32	1	762	1	PPT2	6	32130348	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	116161	32130348	138984719	131	7761										
TAP2	6891	broad.mit.edu	37	chr6	32800587	32800587	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctggccactgcatcctggatCtcccgaagcacttcctggaa	9	15	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:32800587C>A	uc003occ.2	-	5	991	c.960G>T	c.(958-960)GAG>GAT	p.E320D	TAP2_uc011dqf.1_Missense_Mutation_p.E320D|TAP2_uc003ocb.1_Missense_Mutation_p.E320D|TAP2_uc003ocd.2_Missense_Mutation_p.E320D	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	320	Involved in peptide-binding site.|ABC transmembrane type-1.|Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						CATCCTGGATCTCCCGAAGCA	0.612													1	0	0.00448238	0.004482	0.00455872	7	33										A	32800587	C	A	32800587	3	1	28	1	0	0	0	0	1	0	0	0	15548	912	32	3	1213	3	TAP2	6	32800587	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	670239	32800587	138314480	132	7762										
RGL2	5863	broad.mit.edu	37	chr6	33261395	33261395	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tctcactctgtccactgcgaGatgaccaatgttggccgaag	10	12	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:33261395G>C	uc003odv.2	-	14	1723	c.1590C>G	c.(1588-1590)ATC>ATG	p.I530M	RGL2_uc003odu.2_Missense_Mutation_p.I90M|RGL2_uc010jur.2_Missense_Mutation_p.I90M|RGL2_uc003odw.2_Missense_Mutation_p.I448M|RGL2_uc011drb.1_3'UTR	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	530					Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						TCCACTGCGAGATGACCAATG	0.572													0	0	0	0.001855	0	10	40										C	33261395	G	C	33261395	3	2	28	1	0	0	0	0	1	0	0	0	13277	932	33	1	763	1	RGL2	6	33261395	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	460808	33261395	137853672	133	7763										
FKBP5	2289	broad.mit.edu	37	chr6	35565137	35565137	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcccacagtgaatgccacatCtctgcagtcaaacatccttc	6	15	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:35565137C>G	uc011dte.1	-	6	756	c.553G>C	c.(553-555)GAT>CAT	p.D185H	FKBP5_uc003okx.2_Missense_Mutation_p.D185H|FKBP5_uc011dtf.1_Missense_Mutation_p.D6H|FKBP5_uc003oky.2_Missense_Mutation_p.D185H|FKBP5_uc003okz.2_Missense_Mutation_p.D185H	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	185	PPIase FKBP-type 2.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						AATGCCACATCTCTGCAGTCA	0.488													0	0	0	0.004482	0	9	98										G	35565137	C	G	35565137	3	3	28	1	0	0	0	0	1	0	0	0	5911	913	32	1	902	1	FKBP5	6	35565137	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2303742	35565137	135549930	134	7764										
LHFPL5	222662	broad.mit.edu	37	chr6	35773576	35773576	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tccgtactggtcatggccctCttcatccagccctactggat	8	15	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:35773576C>G	uc003olg.1	+	1	506	c.129C>G	c.(127-129)CTC>CTG	p.L43L		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	43	Helical; (Potential).					integral to membrane				skin(1)	1						TCATGGCCCTCTTCATCCAGC	0.592													0	0	0	0.006999	0	35	115										G	35773576	C	G	35773576	2	3	28	1	0	0	0	0	0	0	0	1	8768	900	32	1		1	LHFPL5	6	35773576	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	208439	35773576	135341491	135	7765										
CDKN1A	1026	broad.mit.edu	37	chr6	36652284	36652284	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggtccccaggtggacctggaGactctcagggtcgaaaacgg	15	11	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:36652284G>C	uc003omm.3	+	2	528	c.406G>C	c.(406-408)GAC>CAC	p.D136H	CDKN1A_uc011dtq.1_Missense_Mutation_p.D170H|CDKN1A_uc003oml.2_Missense_Mutation_p.D136H|CDKN1A_uc003omn.2_Missense_Mutation_p.D136H	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	136					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						TGGACCTGGAGACTCTCAGGG	0.587									Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.009096	0	4	33										C	36652284	G	C	36652284	3	2	28	1	0	0	0	0	1	0	0	0	3158	942	33	1	408	1	CDKN1A	6	36652284	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	878708	36652284	134462783	136	7766										
RSPH9	221421	broad.mit.edu	37	chr6	43624433	43624433	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acccctccctggatttcatgGactccttggagcatgacatt	8	13	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:43624433G>A	uc003ovw.1	+	4	669	c.643G>A	c.(643-645)GAC>AAC	p.D215N	RSPH9_uc003ovx.1_Missense_Mutation_p.D200N	NM_152732	NP_689945	Q9H1X1	RSPH9_HUMAN	radial spoke head 9 homolog	215					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton				upper_aerodigestive_tract(1)|skin(1)	2						GGATTTCATGGACTCCTTGGA	0.517									Kartagener_syndrome				0	0	0	0.000978	0	10	434										A	43624433	G	A	43624433	3	1	28	1	0	0	0	0	1	0	0	0	13708	1174	41	1	657	1	RSPH9	6	43624433	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	6972149	43624433	127490634	137	7767										
HSP90AB1	3326	broad.mit.edu	37	chr6	44216498	44216498	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	attttccttcgggagttgatCtctaatgcttctgatgtagg	10	7	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:44216498C>G	uc003oxa.1	+	2	216	c.132C>G	c.(130-132)ATC>ATG	p.I44M	HSP90AB1_uc011dvr.1_Missense_Mutation_p.I44M|HSP90AB1_uc003oxb.1_Missense_Mutation_p.I44M|HSP90AB1_uc011dvs.1_Translation_Start_Site|HSP90AB1_uc003oxc.1_5'Flank	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	44					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGGAGTTGATCTCTAATGCTT	0.433													0	0	0	0.001855	0	12	363										G	44216498	C	G	44216498	3	3	28	1	0	0	0	0	1	0	0	0	7402	903	32	1	134	1	HSP90AB1	6	44216498	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	592065	44216498	126898569	138	7768										
HCRTR2	3062	broad.mit.edu	37	chr6	55120033	55120033	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgtttaagagcacagcaaagCgggcccgtaacagcattgtc	11	10	0	1	rs141639071	by1000genomes	TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:55120033C>T	uc003pcl.2	+	3	817	c.502C>T	c.(502-504)CGG>TGG	p.R168W	HCRTR2_uc010jzv.2_RNA|HCRTR2_uc010jzw.1_Missense_Mutation_p.R103W	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	168	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.R168W(1)		ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CACAGCAAAGCGGGCCCGTAA	0.517													0	0	0	0.001168	0	5	72										T	55120033	C	T	55120033	3	4	28	1	0	0	0	0	1	0	0	0	7002	759	27	2	512	2	HCRTR2	6	55120033	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10903535	55120033	115995034	139	7769										
MYO6	4646	broad.mit.edu	37	chr6	76623906	76623906	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caaagaccctcagagtaagaAaaaaggctggtggtatgccc	11	9	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:76623906A>C	uc003pih.1	+	34	3845	c.3566A>C	c.(3565-3567)AAA>ACA	p.K1189T	MYO6_uc003pii.1_Missense_Mutation_p.K1166T|MYO6_uc003pij.1_Missense_Mutation_p.K137T	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1198					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		CAGAGTAAGAAAAAAGGCTGG	0.532													0	0	0	0.003163	0	15	176										C	76623906	A	C	76623906	3	2	28	1	0	0	0	0	1	0	0	0	10081	14	1	5	3696	5	MYO6	6	76623906	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	21503873	76623906	94491161	140	7770										
L3MBTL3	84456	broad.mit.edu	37	chr6	130413972	130413972	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcaccctgtaggctggtgttCaaaaacaggacatccccttc	8	13	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:130413972C>G	uc003qbt.2	+	17	1771	c.1601C>G	c.(1600-1602)TCA>TGA	p.S534*	L3MBTL3_uc003qbu.2_Nonsense_Mutation_p.S509*	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	534	MBT 3.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		GGCTGGTGTTCAAAAACAGGA	0.408													0	0	0	0.00333	0	23	110										G	130413972	C	G	130413972	4	3	28	1	0	0	0	0	0	1	0	0	8593	838	29	1	1659	1	L3MBTL3	6	130413972	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	53790066	130413972	40701095	141	7771										
TMEM200A	114801	broad.mit.edu	37	chr6	130762701	130762701	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctcttgtctcctggggctgcCagaagacagtttgggtccaa	12	11	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:130762701C>G	uc003qca.2	+	3	2005	c.1134C>G	c.(1132-1134)GCC>GCG	p.A378A	TMEM200A_uc010kfh.2_Silent_p.A378A|TMEM200A_uc010kfi.2_Silent_p.A378A|TMEM200A_uc003qcb.2_Silent_p.A378A	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	378	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CTGGGGCTGCCAGAAGACAGT	0.522													0	0	0	0.001855	0	13	74										G	130762701	C	G	130762701	2	3	28	1	0	0	0	0	0	0	0	1	16120	581	21	4		4	TMEM200A	6	130762701	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	348729	130762701	40352366	142	7772										
NUP43	348995	broad.mit.edu	37	chr6	150067104	150067104	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccattacatcaccatggtgtCtgatatcacacaataactga	5	11	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:150067104C>G	uc003qmz.2	-	2	272	c.215G>C	c.(214-216)AGA>ACA	p.R72T	NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Missense_Mutation_p.R72T	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	72	WD 2.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		ACCATGGTGTCTGATATCACA	0.368													0	0	0	0.002096	0	31	160										G	150067104	C	G	150067104	3	3	28	1	0	0	0	0	1	0	0	0	10765	913	32	1	955	1	NUP43	6	150067104	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	19304403	150067104	21047963	143	7773										
SYNE1	23345	broad.mit.edu	37	chr6	152563519	152563519	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgactcttgagtgtaaggttCtgattcagaccactcctccg	9	11	3	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:152563519C>G	uc010kiw.2	-	107	20351	c.19749G>C	c.(19747-19749)CAG>CAC	p.Q6583H	SYNE1_uc010kiv.2_Missense_Mutation_p.Q1107H|SYNE1_uc003qos.3_Missense_Mutation_p.Q1107H|SYNE1_uc003qot.3_Missense_Mutation_p.Q6512H|SYNE1_uc003qou.3_Missense_Mutation_p.Q6583H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6583	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTGTAAGGTTCTGATTCAGAC	0.473										HNSCC(10;0.0054)			0	0	0	0.005443	0	29	120										G	152563519	C	G	152563519	3	3	28	1	0	0	0	0	1	0	0	0	15442	912	32	1	6877	1	SYNE1	6	152563519	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2496415	152563519	18551548	144	7774										
SYNE1	23345	broad.mit.edu	37	chr6	152771879	152771879	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccaggtgtgtcccttactggGtcccgcactgggagtttcac	12	13	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr6:152771879G>A	uc010kiw.2	-	27	3878	c.3276C>T	c.(3274-3276)GAC>GAT	p.D1092D	SYNE1_uc003qot.3_Silent_p.D1099D|SYNE1_uc003qou.3_Silent_p.D1092D|SYNE1_uc010kjb.1_Silent_p.D1075D|SYNE1_uc003qow.2_Silent_p.D387D|SYNE1_uc003qox.1_Silent_p.D608D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1092	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCCTTACTGGGTCCCGCACTG	0.493										HNSCC(10;0.0054)			0	0	0	0.006214	0	8	263										A	152771879	G	A	152771879	2	1	28	1	0	0	0	0	0	0	0	1	15442	1252	44	2		2	SYNE1	6	152771879	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	208360	152771879	18343188	145	7775										
CYP2W1	54905	broad.mit.edu	37	chr7	1024674	1024674	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgggcgtgggccgggagccGgtggctgacaagattctgca	18	10	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:1024674G>A	uc003sjq.1	+	3	439	c.426G>A	c.(424-426)CCG>CCA	p.P142P	CYP2W1_uc003sjr.1_Silent_p.P142P	NM_017781	NP_060251	Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W,	142					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCCGGGAGCCGGTGGCTGACA	0.677													0	0	0	0.007413	0	14	16										A	1024674	G	A	1024674	2	1	28	1	0	0	0	0	0	0	0	1	4176	1103	39	2		2	CYP2W1	7	1024674	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		1024674	158113989	146	7776										
CHST12	55501	broad.mit.edu	37	chr7	2472655	2472655	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caggcggagcggaggagcgtGctgcggggcttctgcgccaa	19	11	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:2472655G>C	uc003smc.2	+	2	516	c.381G>C	c.(379-381)GTG>GTC	p.V127V	CHST12_uc003smd.2_Silent_p.V127V	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	127	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		GGAGGAGCGTGCTGCGGGGCT	0.706													0	0	0	0.003163	0	16	45										C	2472655	G	C	2472655	2	2	28	1	0	0	0	0	0	0	0	1	3400	1306	46	4		4	CHST12	7	2472655	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1447981	2472655	156666008	147	7777										
DAGLB	221955	broad.mit.edu	37	chr7	6461401	6461401	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctcacactccacgtccagcAcctcactctccgctgacagg	6	20	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:6461401A>T	uc003sqa.2	-	9	1345	c.1175T>A	c.(1174-1176)GTG>GAG	p.V392E	DAGLB_uc003spz.2_Missense_Mutation_p.V89E|DAGLB_uc011jwt.1_Missense_Mutation_p.V206E|DAGLB_uc011jwu.1_Missense_Mutation_p.V263E|DAGLB_uc003sqb.2_Missense_Mutation_p.V111E|DAGLB_uc003sqc.2_Missense_Mutation_p.V111E|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.V351E|DAGLB_uc011jww.1_RNA	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	392	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CACGTCCAGCACCTCACTCTC	0.587													0	0	0	0.001168	0	6	20										T	6461401	A	T	6461401	3	4	28	1	0	0	0	0	1	0	0	0	4227	159	6	5	871	5	DAGLB	7	6461401	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	3988746	6461401	152677262	148	7778										
HDAC9	9734	broad.mit.edu	37	chr7	18975441	18975441	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tattatggtaggttttggtcAtttgacgaagcaattgatga	11	3	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:18975441A>T	uc003suh.2	+	22	2845	c.2804A>T	c.(2803-2805)CAT>CTT	p.H935L	HDAC9_uc003sue.2_Missense_Mutation_p.H935L|HDAC9_uc003sui.2_Missense_Mutation_p.H938L|HDAC9_uc003suj.2_Missense_Mutation_p.H894L|HDAC9_uc003suk.2_Missense_Mutation_p.H183L	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	935	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GGTTTTGGTCATTTGACGAAG	0.353													0	0	0	0.00361	0	60	112										T	18975441	A	T	18975441	3	4	28	1	0	0	0	0	1	0	0	0	7014	217	8	5	3012	5	HDAC9	7	18975441	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	12514040	18975441	140163222	149	7779										
GARS	2617	broad.mit.edu	37	chr7	30673444	30673444	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atcctctgtttgaagggcaaGagactggtaaaaaagagaca	11	6	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:30673444G>C	uc003tbm.2	+	17	2545	c.2188G>C	c.(2188-2190)GAG>CAG	p.E730Q		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	730					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	TGAAGGGCAAGAGACTGGTAA	0.428													0	0	0	0.001855	0	12	55										C	30673444	G	C	30673444	3	2	28	1	0	0	0	0	1	0	0	0	6242	943	33	1	2254	1	GARS	7	30673444	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	11698003	30673444	128465219	150	7780										
PDE1C	5137	broad.mit.edu	37	chr7	31793151	31793151	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcagggcgtttaaaatgacgCaaaggaggcttgatgactgg	15	6	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:31793151C>T	uc003tcm.1	-	18	2446	c.1977G>A	c.(1975-1977)TTG>TTA	p.L659L	PDE1C_uc003tcn.1_Silent_p.L659L|PDE1C_uc003tco.1_Silent_p.L719L	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	659					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TAAAATGACGCAAAGGAGGCT	0.483													0	0	0	0.006999	0	42	37										T	31793151	C	T	31793151	2	4	28	1	0	0	0	0	0	0	0	1	11635	725	25	2		2	PDE1C	7	31793151	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1119707	31793151	127345512	151	7781										
BBS9	27241	broad.mit.edu	37	chr7	33384191	33384191	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttctcaattctgtgtttacAgcaagcgaccgatgttgagg	10	9	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:33384191A>T	uc003tdn.1	+	12	1789	c.1276_splice	c.e12-2	p.Q426_splice	BBS9_uc003tdo.1_Splice_Site_p.Q426_splice|BBS9_uc003tdp.1_Splice_Site_p.Q426_splice|BBS9_uc003tdq.1_Splice_Site_p.Q426_splice|BBS9_uc010kwn.1_Splice_Site|BBS9_uc003tdr.1_5'Flank|BBS9_uc011kao.1_Splice_Site_p.Q304_splice	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2						fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			CTGTGTTTACAGCAAGCGACC	0.388									Bardet-Biedl_syndrome				0	0	0	0.00632	0	26	94										T	33384191	A	T	33384191	5	4	28	1	0	0	0	0	0	0	1	0	1342	202	7	5	1316	5	BBS9	7	33384191	Splice_Site	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	1591040	33384191	125754472	152	7782										
INHBA	3624	broad.mit.edu	37	chr7	41739709	41739709	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	actttgcccacatgaagcttTctgatcgcgttcagaagcgc	9	12	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:41739709T>C	uc003thq.2	-	1	499	c.264A>G	c.(262-264)AGA>AGG	p.R88R	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Silent_p.R88R|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	88					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CATGAAGCTTTCTGATCGCGT	0.522										TSP Lung(11;0.080)			0	0	0	0.008871	0	18	482										C	41739709	T	C	41739709	2	2	28	1	0	0	0	0	0	0	0	1	7741	1780	62	5		5	INHBA	7	41739709	Silent	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	8355518	41739709	117398954	153	7783										
URGCP	55665	broad.mit.edu	37	chr7	43917868	43917868	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	attaacttattcagaaatctCaggtttgtgttgcgcttccc	7	9	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:43917868C>G	uc003tiw.2	-	6	1251	c.1194G>C	c.(1192-1194)CTG>CTC	p.L398L	URGCP_uc003tiu.2_Silent_p.L355L|URGCP_uc003tiv.2_Silent_p.L323L|URGCP_uc003tix.2_Silent_p.L389L|URGCP_uc003tiy.2_Silent_p.L355L|URGCP_uc003tiz.2_Silent_p.L355L|URGCP_uc011kbj.1_Silent_p.L355L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	398					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						TCAGAAATCTCAGGTTTGTGT	0.448													0	0	0	0.006214	0	8	210										G	43917868	C	G	43917868	2	3	28	1	0	0	0	0	0	0	0	1	17023	813	29	1		1	URGCP	7	43917868	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2178159	43917868	115220795	154	7784										
ABCB4	5244	broad.mit.edu	37	chr7	87032471	87032471	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttttcactttcagtatccaGagctgatgtagcttcatcca	6	11	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:87032471G>C	uc003uiv.1	-	27	3710	c.3634C>G	c.(3634-3636)CTG>GTG	p.L1212V	ABCB4_uc003uiw.1_Missense_Mutation_p.L1205V|ABCB4_uc003uix.1_Missense_Mutation_p.L1158V	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	1212	ABC transporter 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCAGTATCCAGAGCTGATGTA	0.433													0	0	0	0.005524	0	39	233										C	87032471	G	C	87032471	3	2	28	1	0	0	0	0	1	0	0	0	43	933	33	1	234	1	ABCB4	7	87032471	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	43114603	87032471	72106192	155	7785										
SAMD9	54809	broad.mit.edu	37	chr7	92732369	92732369	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagtatcgaagaacaaattCtcagttagcatatccaacat	5	10	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:92732369C>T	uc003umf.2	-	3	3298	c.3042G>A	c.(3040-3042)GAG>GAA	p.E1014E	SAMD9_uc003umg.2_Silent_p.E1014E	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1014						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AGAACAAATTCTCAGTTAGCA	0.373													0	0	0	0.00361	0	72	86										T	92732369	C	T	92732369	2	4	28	1	0	0	0	0	0	0	0	1	13826	912	32	1		1	SAMD9	7	92732369	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5699898	92732369	66406294	156	7786										
TRRAP	8295	broad.mit.edu	37	chr7	98547739	98547739	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agctgctccgagcctttactGgtcgttttctctgcaacatg	9	12	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:98547739G>C	uc003upp.2	+	37	5376	c.5167G>C	c.(5167-5169)GGT>CGT	p.G1723R	TRRAP_uc011kis.1_Missense_Mutation_p.G1705R|TRRAP_uc003upr.2_Missense_Mutation_p.G1422R	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1723					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCCTTTACTGGTCGTTTTCT	0.413													0	0	0	0.008291	0	10	201										C	98547739	G	C	98547739	3	2	28	1	0	0	0	0	1	0	0	0	16598	1348	47	4	5251	4	TRRAP	7	98547739	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	5815370	98547739	60590924	157	7787										
TRRAP	8295	broad.mit.edu	37	chr7	98588176	98588176	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cccatccagtggctggcctgGatcccacagctgctcacctg	10	17	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:98588176G>T	uc003upp.2	+	63	9911	c.9702G>T	c.(9700-9702)TGG>TGT	p.W3234C	TRRAP_uc011kis.1_Missense_Mutation_p.W3205C|TRRAP_uc003upr.2_Missense_Mutation_p.W2922C	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3234	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGCTGGCCTGGATCCCACAGC	0.552													1	0	1.33834e-09	0.007413	1.44929e-09	12	68										T	98588176	G	T	98588176	3	4	28	1	0	0	0	0	1	0	0	0	16598	1183	41	3	9857	3	TRRAP	7	98588176	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	40437	98588176	60550487	158	7788										
DNAJB9	4189	broad.mit.edu	37	chr7	108212184	108212184	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	attagaaatggctactccccAgtcaattttcatctttgcaa	5	10	3	1	rs78948360		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:108212184A>C	uc003vfn.2	+	2	216	c.14A>C	c.(13-15)CAG>CCG	p.Q5P	THAP5_uc003vfl.2_5'Flank|THAP5_uc003vfm.2_5'Flank	NM_012328	NP_036460	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	5					ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding				0						GCTACTCCCCAGTCAATTTTC	0.318													0	0	0	0.007413	0	13	85										C	108212184	A	C	108212184	3	2	28	1	0	0	0	0	1	0	0	0	4627	188	7	5	16	5	DNAJB9	7	108212184	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	9624008	108212184	50926479	159	7789										
FOXP2	93986	broad.mit.edu	37	chr7	114299626	114299626	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgtatcttgtctcatttcaGgctatcatggagtcatctga	8	8	6	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:114299626G>C	uc003vhb.2	+	13	1920	c.1546_splice	c.e13-1	p.A516_splice	FOXP2_uc003vgu.2_Splice_Site|FOXP2_uc003vgz.2_Splice_Site_p.A541_splice|FOXP2_uc003vha.2_Splice_Site_p.A424_splice|FOXP2_uc011kmu.1_Splice_Site_p.A533_splice|FOXP2_uc011kmv.1_Splice_Site_p.A515_splice|FOXP2_uc010ljz.1_Splice_Site_p.A331_splice|FOXP2_uc003vhe.1_Splice_Site_p.A86_splice	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I						camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TCTCATTTCAGGCTATCATGG	0.363													0	0	0	0.003163	0	14	130										C	114299626	G	C	114299626	5	2	28	1	0	0	0	0	0	0	1	0	6027	1014	35	4	1758	4	FOXP2	7	114299626	Splice_Site	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	6087442	114299626	44839037	160	7790										
LMOD2	442721	broad.mit.edu	37	chr7	123302335	123302335	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aacacagacccttacccgctTtgctgaagccctcaaggaca	7	15	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:123302335T>C	uc003vky.2	+	2	852	c.695T>C	c.(694-696)TTT>TCT	p.F232S		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	232						cytoskeleton	actin binding|tropomyosin binding				0						CTTACCCGCTTTGCTGAAGCC	0.488													0	0	0	0.001168	0	5	21										C	123302335	T	C	123302335	3	2	28	1	0	0	0	0	1	0	0	0	8857	1841	64	5	701	5	LMOD2	7	123302335	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	9002709	123302335	35836328	161	7791										
FAM40B	57464	broad.mit.edu	37	chr7	129110495	129110495	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctctgcatcttacagcatctCagtcctggattatccttgct	6	13	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:129110495C>G	uc011koy.1	+	18	1923	c.1883C>G	c.(1882-1884)TCA>TGA	p.S628*	FAM40B_uc003vow.2_Nonsense_Mutation_p.S628*|FAM40B_uc011koz.1_Nonsense_Mutation_p.S120*	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	628											0						TACAGCATCTCAGTCCTGGAT	0.463													0	0	0	0.009096	0	4	42										G	129110495	C	G	129110495	4	3	28	1	0	0	0	0	0	1	0	0	5561	838	29	1	1953	1	FAM40B	7	129110495	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5808160	129110495	30028168	162	7792										
AKR1B15	441282	broad.mit.edu	37	chr7	134261766	134261766	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgacagtgatccccaagtctAtgacaccagcacacattgtt	7	12	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:134261766A>G	uc011kpr.1	+	10	1176	c.877A>G	c.(877-879)ATG>GTG	p.M293V	AKR1B15_uc011kps.1_Missense_Mutation_p.M265V	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	293	NADP (By similarity).						oxidoreductase activity			ovary(1)	1						CCCCAAGTCTATGACACCAGC	0.517													0	0	0	0.001168	0	5	120										G	134261766	A	G	134261766	3	3	28	1	0	0	0	0	1	0	0	0	468	449	16	5	907	5	AKR1B15	7	134261766	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	5151271	134261766	24876897	163	7793										
TAS2R60	338398	broad.mit.edu	37	chr7	143141091	143141091	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caaccttggaatgtcactggCgatagcatacggagctactg	11	10	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr7:143141091C>T	uc011ktg.1	+	1	546	c.546C>T	c.(544-546)GGC>GGT	p.G182G	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	182	Extracellular (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					ATGTCACTGGCGATAGCATAC	0.408													0	0	0	0.008291	0	11	226										T	143141091	C	T	143141091	2	4	28	1	0	0	0	0	0	0	0	1	15582	755	27	2		2	TAS2R60	7	143141091	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	8879325	143141091	15997572	164	7794										
CLN8	2055	broad.mit.edu	37	chr8	1728460	1728460	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tggaagctcaaccagtggctGatgattcacatgtttcactg	10	9	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:1728460G>A	uc003wpo.3	+	3	893	c.588G>A	c.(586-588)CTG>CTA	p.L196L		NM_018941	NP_061764	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8	196	TLC.				cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		ACCAGTGGCTGATGATTCACA	0.517													0	0	0	0.007413	0	19	54										A	1728460	G	A	1728460	2	1	28	1	0	0	0	0	0	0	0	1	3546	1277	45	1		1	CLN8	8	1728460	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		1728460	144635562	165	7795										
MCPH1	79648	broad.mit.edu	37	chr8	6312749	6312749	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atcaaacctcatgaggaattGaagaaaagtgggagaggcaa	12	5	2	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:6312749G>C	uc003wqi.2	+	9	1979	c.1911G>C	c.(1909-1911)TTG>TTC	p.L637F		NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	637						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		ATGAGGAATTGAAGAAAAGTG	0.368													0	0	0	0.002299	0	24	106										C	6312749	G	C	6312749	3	2	28	1	0	0	0	0	1	0	0	0	9398	1281	45	1	1953	1	MCPH1	8	6312749	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4584289	6312749	140051273	166	7796										
C8orf74	203076	broad.mit.edu	37	chr8	10555323	10555323	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgccaccccatcccctcccGctggccgagggcatggacag	11	18	0	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:10555323G>A	uc003wtd.1	+	3	485	c.456G>A	c.(454-456)CCG>CCA	p.P152P	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	152											0				COAD - Colon adenocarcinoma(149;0.0811)		ATCCCCTCCCGCTGGCCGAGG	0.652													0	0	0	0.008871	0	17	36										A	10555323	G	A	10555323	2	1	28	1	0	0	0	0	0	0	0	1	2436	1074	38	2		2	C8orf74	8	10555323	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4242574	10555323	135808699	167	7797										
UNC5D	137970	broad.mit.edu	37	chr8	35541109	35541109	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cccattgactctgaacaagaCgagaacattgacaccagggc	9	12	1	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:35541109C>T	uc003xjr.1	+	5	943	c.615C>T	c.(613-615)GAC>GAT	p.D205D	UNC5D_uc003xjs.1_Silent_p.D200D|UNC5D_uc003xjt.1_Translation_Start_Site	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	205	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTGAACAAGACGAGAACATTG	0.463													0	0	0	0.009096	0	3	27										T	35541109	C	T	35541109	2	4	28	1	0	0	0	0	0	0	0	1	16992	535	19	2		2	UNC5D	8	35541109	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	24985786	35541109	110822913	168	7798										
ADAM2	2515	broad.mit.edu	37	chr8	39604118	39604118	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaatggccatctcattggttTggaatggtaaatgttctcaa	9	6	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:39604118T>A	uc003xnj.2	-	19	2122	c.2047A>T	c.(2047-2049)AAA>TAA	p.K683*	ADAM2_uc003xnk.2_Nonsense_Mutation_p.K664*|ADAM2_uc011lck.1_Nonsense_Mutation_p.K620*|ADAM2_uc003xnl.2_Nonsense_Mutation_p.K527*	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	683	Extracellular (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTCATTGGTTTGGAATGGTAA	0.294													0	0	0	0.00499	0	17	106										A	39604118	T	A	39604118	4	1	28	1	0	0	0	0	0	1	0	0	241	1821	63	5	168	5	ADAM2	8	39604118	Nonsense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	4063009	39604118	106759904	169	7799										
CHRNB3	1142	broad.mit.edu	37	chr8	42585836	42585836	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgtggcttcctgacatagttCtctttgaaaagtaagtatca	8	7	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:42585836C>A	uc003xpi.1	+	4	477	c.349C>A	c.(349-351)CTC>ATC	p.L117I		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	117	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGACATAGTTCTCTTTGAAAA	0.299													1	0	9.31168e-06	0.001855	9.80424e-06	14	34										A	42585836	C	A	42585836	3	1	28	1	0	0	0	0	1	0	0	0	3392	913	32	3	363	3	CHRNB3	8	42585836	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2981718	42585836	103778186	170	7800										
EFCAB1	79645	broad.mit.edu	37	chr8	49642408	49642408	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaaatgaatccgtcaccattCaaatcaaacacttcaaagca	4	11	4	1	rs145734570	byFrequency	TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:49642408C>G	uc003xqo.2	-	4	502	c.342G>C	c.(340-342)TTG>TTC	p.L114F	EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Missense_Mutation_p.L62F|EFCAB1_uc010lxx.2_Intron|EFCAB1_uc011ldk.1_Intron	NM_024593	NP_078869	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1 isoform a	114	2 (Potential).|EF-hand 2.						calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				CGTCACCATTCAAATCAAACA	0.348													0	0	0	0.000602	0	5	56										G	49642408	C	G	49642408	3	3	28	1	0	0	0	0	1	0	0	0	4933	825	29	1	305	1	EFCAB1	8	49642408	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7056572	49642408	96721614	171	7801										
TGS1	96764	broad.mit.edu	37	chr8	56698335	56698335	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgtggtactgcagaatcacAtgacagcaaaggcataggcc	11	10	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:56698335A>T	uc003xsj.3	+	3	611	c.224A>T	c.(223-225)CAT>CTT	p.H75L	TGS1_uc010lyh.2_5'UTR	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	75					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GCAGAATCACATGACAGCAAA	0.413													0	0	0	0.009535	0	31	55										T	56698335	A	T	56698335	3	4	28	1	0	0	0	0	1	0	0	0	15834	217	8	5	234	5	TGS1	8	56698335	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	7055927	56698335	89665687	172	7802										
TGS1	96764	broad.mit.edu	37	chr8	56715061	56715061	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaagaagaacaaaaaggtgaAtggtctgcctcctgaaatag	11	6	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:56715061A>C	uc003xsj.3	+	9	2282	c.1895A>C	c.(1894-1896)AAT>ACT	p.N632T	TGS1_uc010lyh.2_Missense_Mutation_p.N536T	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	632	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			aaaaagGTGAATGGTCTGCCT	0.338													0	0	0	0.008291	0	11	49										C	56715061	A	C	56715061	3	2	28	1	0	0	0	0	1	0	0	0	15834	101	4	5	1929	5	TGS1	8	56715061	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	16726	56715061	89648961	173	7803										
OSR2	116039	broad.mit.edu	37	chr8	99961627	99961627	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgggtagccccatctcgggCctcagtaaattgactccgga	11	13	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:99961627C>A	uc003yir.2	+	2	982	c.447C>A	c.(445-447)GGC>GGA	p.G149G	OSR2_uc010mbn.2_Silent_p.G149G|OSR2_uc003yiq.2_Silent_p.G149G|OSR2_uc011lgx.1_Silent_p.G270G	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	149					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CCATCTCGGGCCTCAGTAAAT	0.532													1	0	0.00316338	0.003163	0.0032251	14	218										A	99961627	C	A	99961627	2	1	28	1	0	0	0	0	0	0	0	1	11294	726	26	4		4	OSR2	8	99961627	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	43246566	99961627	46402395	174	7804										
ATP6V1C1	528	broad.mit.edu	37	chr8	104054610	104054610	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttggcttgtcagatgaactgGctaaactggatgcatttgta	11	6	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:104054610G>C	uc003ykz.3	+	3	420	c.175G>C	c.(175-177)GCT>CCT	p.A59P	ATP6V1C1_uc010mbz.2_5'UTR|ATP6V1C1_uc003yla.2_Missense_Mutation_p.A59P|ATP6V1C1_uc011lhl.1_Intron	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	59					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			AGATGAACTGGCTAAACTGGA	0.368													0	0	0	0.004482	0	8	192										C	104054610	G	C	104054610	3	2	28	1	0	0	0	0	1	0	0	0	1180	1203	42	4	181	4	ATP6V1C1	8	104054610	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4092983	104054610	42309412	175	7805										
PKHD1L1	93035	broad.mit.edu	37	chr8	110412320	110412320	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttaggagggagaggcctgaAgcttgaggtgtggaataata	16	4	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:110412320A>G	uc003yne.2	+	13	1132	c.1028A>G	c.(1027-1029)AAG>AGG	p.K343R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	343	Extracellular (Potential).|IPT/TIG 3.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGAGGCCTGAAGCTTGAGGTG	0.408										HNSCC(38;0.096)			0	0	0	0.001168	0	6	172										G	110412320	A	G	110412320	3	3	28	1	0	0	0	0	1	0	0	0	11972	72	3	5	1078	5	PKHD1L1	8	110412320	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	6357710	110412320	35951702	176	7806										
CSMD3	114788	broad.mit.edu	37	chr8	113358347	113358347	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaaacctatgggtagatttaTtgtccatgtgcaatctaaac	7	7	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:113358347T>G	uc003ynu.2	-	41	6580	c.6421A>C	c.(6421-6423)ATA>CTA	p.I2141L	CSMD3_uc003yns.2_Missense_Mutation_p.I1343L|CSMD3_uc003ynt.2_Missense_Mutation_p.I2101L|CSMD3_uc011lhx.1_Missense_Mutation_p.I2037L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2141	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTAGATTTATTGTCCATGTG	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.00361	0	45	167										G	113358347	T	G	113358347	3	3	28	1	0	0	0	0	1	0	0	0	3946	1493	52	5	4826	5	CSMD3	8	113358347	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	2946027	113358347	33005675	177	7807										
TRPS1	7227	broad.mit.edu	37	chr8	116599614	116599614	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caccacactctcagaaactgGctctcccattttagagtctg	6	14	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:116599614G>C	uc003ynz.2	-	4	2734	c.2275C>G	c.(2275-2277)CCA>GCA	p.P759A	TRPS1_uc011lhy.1_Missense_Mutation_p.P763A|TRPS1_uc003yny.2_Missense_Mutation_p.P772A|TRPS1_uc010mcy.2_Missense_Mutation_p.P759A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	759	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCAGAAACTGGCTCTCCCATT	0.493									Langer-Giedion_syndrome				0	0	0	0.004878	0	35	439										C	116599614	G	C	116599614	3	2	28	1	0	0	0	0	1	0	0	0	16590	1203	42	4	1582	4	TRPS1	8	116599614	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3241267	116599614	29764408	178	7808										
HSF1	3297	broad.mit.edu	37	chr8	145535686	145535686	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccctggtgcgtgtcaaggagGagccccccagcccgcctcag	13	17	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:145535686G>C	uc003zbt.3	+	9	1068	c.898G>C	c.(898-900)GAG>CAG	p.E300Q	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	300	Regulatory domain.			E->A: Derepression of transcriptional activity at control temperature by 11%.		cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			TGTCAAGGAGGAGCCCCCCAG	0.701													0	0	0	0.000602	0	5	13										C	145535686	G	C	145535686	3	2	28	1	0	0	0	0	1	0	0	0	7395	1175	41	1	932	1	HSF1	8	145535686	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	28936072	145535686	828336	179	7809										
KIFC2	90990	broad.mit.edu	37	chr8	145693255	145693255	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccaccagggggcgacggactCagagaaaagggttcagcatc	14	11	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:145693255C>G	uc003zcz.2	+	7	760	c.695C>G	c.(694-696)TCA>TGA	p.S232*	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	232	Potential.|Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCGACGGACTCAGAGAAAAGG	0.667											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	59										G	145693255	C	G	145693255	4	3	28	1	0	0	0	0	0	1	0	0	8313	838	29	1	721	1	KIFC2	8	145693255	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	157569	145693255	670767	180	7810										
ZNF16	7564	broad.mit.edu	37	chr8	146157055	146157055	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cacactcaaaaggcttctctCctgtgtgagtcctgtggtgt	10	11	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr8:146157055C>A	uc003zet.2	-	4	1305	c.1118G>T	c.(1117-1119)GGA>GTA	p.G373V	ZNF16_uc003zeu.2_Missense_Mutation_p.G373V	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		AGGCTTCTCTCCTGTGTGAGT	0.532													1	0	0.00909568	0.009096	0.00918356	4	115										A	146157055	C	A	146157055	3	1	28	1	0	0	0	0	1	0	0	0	17735	855	30	3	934	3	ZNF16	8	146157055	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	463800	146157055	206967	181	7811										
MLLT3	4300	broad.mit.edu	37	chr9	20620762	20620762	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aacaccatccagtcgtgggtGaagccctccacggtgggttt	12	12	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:20620762G>A	uc003zoe.2	-	2	343	c.84C>T	c.(82-84)TTC>TTT	p.F28F	MLLT3_uc011lne.1_5'UTR|MLLT3_uc011lnf.1_Silent_p.F25F|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	28	YEATS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		AGTCGTGGGTGAAGCCCTCCA	0.602			T	MLL	ALL								0	0	0	0.00333	0	21	119										A	20620762	G	A	20620762	2	1	28	1	0	0	0	0	0	0	0	1	9628	1281	45	1		1	MLLT3	9	20620762	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		20620762	120592669	182	7812										
ZCCHC7	84186	broad.mit.edu	37	chr9	37126516	37126516	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaaagaactctgggaattcgGaatcttcgagtagtaaacca	9	7	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:37126516G>C	uc003zzq.2	+	2	360	c.187G>C	c.(187-189)GAA>CAA	p.E63Q	ZCCHC7_uc011lqh.1_Intron|ZCCHC7_uc011lqi.1_Missense_Mutation_p.E62Q|ZCCHC7_uc010mlt.2_Missense_Mutation_p.E62Q|ZCCHC7_uc003zzs.1_Missense_Mutation_p.E62Q	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	63							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		TGGGAATTCGGAATCTTCGAG	0.423													0	0	0	0.006214	0	10	226										C	37126516	G	C	37126516	3	2	28	1	0	0	0	0	1	0	0	0	17590	1175	41	1	189	1	ZCCHC7	9	37126516	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	16505754	37126516	104086915	183	7813										
VPS13A	23230	broad.mit.edu	37	chr9	79890500	79890500	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gagttaaaagtattcgaaccAgaaagttacaaaagcaggat	9	5	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:79890500A>C	uc004akr.2	+	25	2859	c.2599A>C	c.(2599-2601)AGA>CGA	p.R867R	VPS13A_uc004akp.3_Silent_p.R867R|VPS13A_uc004akq.3_Silent_p.R867R|VPS13A_uc004aks.2_Silent_p.R867R	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	867					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TATTCGAACCAGAAAGTTACA	0.348													0	0	0	0.00632	0	30	170										C	79890500	A	C	79890500	2	2	28	1	0	0	0	0	0	0	0	1	17186	180	7	5		5	VPS13A	9	79890500	Silent	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	42763984	79890500	61322931	184	7814										
CEP78	84131	broad.mit.edu	37	chr9	80881397	80881397	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgctagaattcctttgcctCtcgactcctttcctgtccca	5	15	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:80881397C>G	uc004akx.2	+	15	2113	c.1837C>G	c.(1837-1839)CTC>GTC	p.L613V	CEP78_uc004aky.3_Missense_Mutation_p.L630V|CEP78_uc010mpp.2_Missense_Mutation_p.L614V|CEP78_uc004akz.1_Missense_Mutation_p.L101V	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	613					G2/M transition of mitotic cell cycle	centrosome|cytosol		p.L613L(1)		ovary(1)	1						TCCTTTGCCTCTCGACTCCTT	0.428													0	0	0	0.004482	0	8	62										G	80881397	C	G	80881397	3	3	28	1	0	0	0	0	1	0	0	0	3262	913	32	1	1950	1	CEP78	9	80881397	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	990897	80881397	60332034	185	7815										
FLJ46321	389763	broad.mit.edu	37	chr9	84608089	84608089	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttagttccaacaaacaaaagAtgttggaagcccatattaaa	6	7	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:84608089A>G	uc004amn.2	+	4	2751	c.2704A>G	c.(2704-2706)ATG>GTG	p.M902V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	902						integral to membrane					0						CAAACAAAAGATGTTGGAAGC	0.433													0	0	0	0.000602	0	4	63										G	84608089	A	G	84608089	3	3	28	1	0	0	0	0	1	0	0	0	5932	333	12	5	2718	5	FLJ46321	9	84608089	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	3726692	84608089	56605342	186	7816										
PTCH1	5727	broad.mit.edu	37	chr9	98239043	98239043	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttttgtttttgcattacctCaaaagggattcttttattct	5	7	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:98239043C>G	uc004avk.3	-	11	1788	c.1600G>C	c.(1600-1602)GAG>CAG	p.E534Q	PTCH1_uc010mro.2_Missense_Mutation_p.E383Q|PTCH1_uc010mrp.2_Missense_Mutation_p.E383Q|PTCH1_uc010mrq.2_Missense_Mutation_p.E383Q|PTCH1_uc004avl.3_Missense_Mutation_p.E383Q|PTCH1_uc010mrr.2_Missense_Mutation_p.E468Q|PTCH1_uc004avm.3_Missense_Mutation_p.E533Q|PTCH1_uc010mrs.1_Missense_Mutation_p.E202Q	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	534	SSD.|Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TGCATTACCTCAAAAGGGATT	0.423									Basal_Cell_Nevus_syndrome				0	0	0	0.000602	0	4	23										G	98239043	C	G	98239043	3	3	28	1	0	0	0	0	1	0	0	0	12730	835	29	1	2795	1	PTCH1	9	98239043	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	13630954	98239043	42974388	187	7817										
EPB41L4B	54566	broad.mit.edu	37	chr9	112018480	112018480	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcctgtcggggtcagtccaaGagaatattcacagccatctc	10	12	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:112018480G>C	uc004bdz.1	-	9	1160	c.865C>G	c.(865-867)CTT>GTT	p.L289V	EPB41L4B_uc004bea.2_Missense_Mutation_p.L289V	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	289	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						GTCAGTCCAAGAGAATATTCA	0.368													0	0	0	0.002836	0	30	159										C	112018480	G	C	112018480	3	2	28	1	0	0	0	0	1	0	0	0	5156	942	33	1	2061	1	EPB41L4B	9	112018480	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	13779437	112018480	29194951	188	7818										
PTPN3	5774	broad.mit.edu	37	chr9	112185044	112185044	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agaaggcagactcttggtttCtaagtgctccactgataagg	11	8	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:112185044C>G	uc004bed.2	-	13	1202	c.1090G>C	c.(1090-1092)GAA>CAA	p.E364Q	PTPN3_uc004beb.2_Missense_Mutation_p.E233Q|PTPN3_uc004bec.2_Intron|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Intron|PTPN3_uc011lwh.1_Intron|PTPN3_uc011lwe.1_Missense_Mutation_p.E77Q|PTPN3_uc011lwf.1_Intron	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	364					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CTCTTGGTTTCTAAGTGCTCC	0.448													0	0	0	0.001168	0	5	212										G	112185044	C	G	112185044	3	3	28	1	0	0	0	0	1	0	0	0	12789	922	32	1	1707	1	PTPN3	9	112185044	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	166564	112185044	29028387	189	7819										
SVEP1	79987	broad.mit.edu	37	chr9	113198707	113198707	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaggttgagctggcttatggAgcccacaaaagactcagctg	13	9	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:113198707A>T	uc010mtz.2	-	28	5054	c.4717T>A	c.(4717-4719)TCC>ACC	p.S1573T		NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1573	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TGGCTTATGGAGCCCACAAAA	0.473													0	0	0	0.009096	0	4	104										T	113198707	A	T	113198707	3	4	28	1	0	0	0	0	1	0	0	0	15417	304	11	5	6082	5	SVEP1	9	113198707	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	1013663	113198707	28014724	190	7820										
DFNB31	25861	broad.mit.edu	37	chr9	117240927	117240927	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cgtggggctggggcaggcccGagggtggggagatgctgcgg	24	8	0	1	rs141863996		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:117240927G>A	uc004biz.3	-	2	1392	c.743C>T	c.(742-744)TCG>TTG	p.S248L	DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Missense_Mutation_p.S248L|DFNB31_uc004bjb.2_Missense_Mutation_p.S248L	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	248					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GGGCAGGCCCGAGGGTGGGGA	0.662													0	0	0	0.008291	0	7	11										A	117240927	G	A	117240927	3	1	28	1	0	0	0	0	1	0	0	0	4455	1059	37	1	2024	1	DFNB31	9	117240927	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4042220	117240927	23972504	191	7821										
PAPPA	5069	broad.mit.edu	37	chr9	118949701	118949701	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaacaagtgggtggcatattCagcccactgacccagaagtg	12	10	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:118949701C>G	uc004bjn.2	+	2	1065	c.684C>G	c.(682-684)TTC>TTG	p.F228L	PAPPA_uc011lxp.1_Missense_Mutation_p.F21L|PAPPA_uc011lxq.1_Missense_Mutation_p.F21L	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	228					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGGCATATTCAGCCCACTGA	0.547													0	0	0	0.003163	0	16	60										G	118949701	C	G	118949701	3	3	28	1	0	0	0	0	1	0	0	0	11432	825	29	1	690	1	PAPPA	9	118949701	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1708774	118949701	22263730	192	7822										
C5	727	broad.mit.edu	37	chr9	123716141	123716141	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agagtctttctcagcaacagCttcccctgagagacatgcaa	8	12	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:123716141C>T	uc004bkv.2	-	40	4798	c.4768G>A	c.(4768-4770)GCT>ACT	p.A1590T		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1590	NTR.				activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TCAGCAACAGCTTCCCCTGAG	0.383													0	0	0	0.00278	0	21	100										T	123716141	C	T	123716141	3	4	28	1	0	0	0	0	1	0	0	0	2280	797	28	2	270	2	C5	9	123716141	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4766440	123716141	17497290	193	7823										
CIZ1	25792	broad.mit.edu	37	chr9	130940682	130940682	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcgctctgttttcacattctCccacatctaggccacaggcc	6	16	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:130940682C>G	uc004btt.2	-	9	1749	c.1586G>C	c.(1585-1587)GGA>GCA	p.G529A	CIZ1_uc004btr.2_Missense_Mutation_p.G501A|CIZ1_uc004bts.2_Missense_Mutation_p.G500A|CIZ1_uc011maq.1_Missense_Mutation_p.G468A|CIZ1_uc004btu.2_Missense_Mutation_p.G449A|CIZ1_uc011mar.1_Missense_Mutation_p.G428A|CIZ1_uc011mas.1_Missense_Mutation_p.G559A|CIZ1_uc004btw.2_Missense_Mutation_p.G473A|CIZ1_uc004btv.2_Missense_Mutation_p.G529A	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	529						nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						TTCACATTCTCCCACATCTAG	0.562													0	0	0	0.00499	0	13	168										G	130940682	C	G	130940682	3	3	28	1	0	0	0	0	1	0	0	0	3441	855	30	1	1146	1	CIZ1	9	130940682	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7224541	130940682	10272749	194	7824										
LAMC3	10319	broad.mit.edu	37	chr9	133927972	133927972	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tccccactccctgtacagctGaggctggaagggacaggctt	12	13	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:133927972G>C	uc004caa.1	+	10	1823	c.1725G>C	c.(1723-1725)CTG>CTC	p.L575L		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	575	Laminin IV type A.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTGTACAGCTGAGGCTGGAAG	0.642											OREG0019556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00499	0	12	53										C	133927972	G	C	133927972	2	2	28	1	0	0	0	0	0	0	0	1	8616	1277	45	1		1	LAMC3	9	133927972	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2987290	133927972	7285459	195	7825										
SETX	23064	broad.mit.edu	37	chr9	135204838	135204838	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtgtatatgaagagatctctTttacagacttctgcttcctt	7	8	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:135204838T>C	uc004cbk.2	-	10	2330	c.2147A>G	c.(2146-2148)AAA>AGA	p.K716R	SETX_uc004cbj.2_Missense_Mutation_p.K335R|SETX_uc010mzt.2_Missense_Mutation_p.K335R	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	716					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AGAGATCTCTTTTACAGACTT	0.363													0	0	0	0.00361	0	66	173										C	135204838	T	C	135204838	3	2	28	1	0	0	0	0	1	0	0	0	14141	1841	64	5	5954	5	SETX	9	135204838	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	1276866	135204838	6008593	196	7826										
C9orf98	158067	broad.mit.edu	37	chr9	135601228	135601228	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aacaggtccattttcagcttGacctgctcttcagcatcctt	6	13	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:135601228G>C	uc004cbu.1	-	13	1843	c.1287C>G	c.(1285-1287)GTC>GTG	p.V429V	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Silent_p.V225V	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	429	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		TTTTCAGCTTGACCTGCTCTT	0.552													0	0	0	0.004672	0	3	10										C	135601228	G	C	135601228	2	2	28	1	0	0	0	0	0	0	0	1	2509	1277	45	1		1	C9orf98	9	135601228	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	396390	135601228	5612203	197	7827										
C9orf98	158067	broad.mit.edu	37	chr9	135702366	135702366	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tctgagccgtctccagctctGagatgtcctctggcaccatg	10	14	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:135702366G>C	uc004cbu.1	-	8	1188	c.632C>G	c.(631-633)TCA>TGA	p.S211*	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Nonsense_Mutation_p.S7*	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	211						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		CTCCAGCTCTGAGATGTCCTC	0.502													0	0	0	0.001168	0	5	287										C	135702366	G	C	135702366	4	2	28	1	0	0	0	0	0	1	0	0	2509	1294	45	1	831	1	C9orf98	9	135702366	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	101138	135702366	5511065	198	7828										
FAM166A	401565	broad.mit.edu	37	chr9	140139656	140139656	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggggtgggtactcatccctCtggcagtggtacagctggag	17	9	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:140139656C>G	uc004cmi.1	-	4	592	c.537G>C	c.(535-537)CAG>CAC	p.Q179H		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	179										ovary(1)	1						ACTCATCCCTCTGGCAGTGGT	0.667													0	0	0	0.001168	0	4	45										G	140139656	C	G	140139656	3	3	28	1	0	0	0	0	1	0	0	0	5481	912	32	1	432	1	FAM166A	9	140139656	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4437290	140139656	1073775	199	7829										
FAM166A	401565	broad.mit.edu	37	chr9	140139944	140139944	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gttctctacccctggcggctCctgggcgtccacctccaagg	11	17	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:140139944C>G	uc004cmi.1	-	3	392	c.337G>C	c.(337-339)GAG>CAG	p.E113Q		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	113										ovary(1)	1						CCTGGCGGCTCCTGGGCGTCC	0.627													0	0	0	0.004007	0	14	91										G	140139944	C	G	140139944	3	3	28	1	0	0	0	0	1	0	0	0	5481	864	30	1	636	1	FAM166A	9	140139944	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	288	140139944	1073487	200	7830										
CACNA1B	774	broad.mit.edu	37	chr9	140907677	140907677	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccatgtctgccgcgaacatcTccatcgccgcgtaaggctcc	9	17	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr9:140907677T>G	uc004cog.2	+	18	2402	c.2257T>G	c.(2257-2259)TCC>GCC	p.S753A	CACNA1B_uc011mfd.1_Missense_Mutation_p.S284A	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	753	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGCGAACATCTCCATCGCCGC	0.602													0	0	0	0.006214	0	7	26										G	140907677	T	G	140907677	3	3	28	1	0	0	0	0	1	0	0	0	2539	1551	54	5	2327	5	CACNA1B	9	140907677	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	767733	140907677	305754	201	7831										
USP6NL	9712	broad.mit.edu	37	chr10	11505382	11505382	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggacctgggacggtaactgcGagcgcggggtgcgctgctcg	19	11	0	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:11505382G>A	uc001ikt.3	-	15	1866	c.1545C>T	c.(1543-1545)CTC>CTT	p.L515L	USP6NL_uc001iks.1_Silent_p.L532L	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	515						intracellular	Rab GTPase activator activity				0						CGGTAACTGCGAGCGCGGGGT	0.587													0	0	0	0.00333	0	23	145										A	11505382	G	A	11505382	2	1	28	1	0	0	0	0	0	0	0	1	17084	1045	37	1		1	USP6NL	10	11505382	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		11505382	124029365	202	7832										
DHTKD1	55526	broad.mit.edu	37	chr10	12160750	12160750	+	Frame_Shift_Del	DEL	T	T	-													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tccttttctgtccaacagggTtaagaccctcgtgttctgct							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:12160750delT	uc001ild.3	+	15	2504	c.2405delT	c.(2404-2406)GTTfs	p.V802fs		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	802					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TCCAACAGGGTTAAGACCCTC	0.378																		22	543	---	---								-	12160750	T	-	12160750	7	5	28	1	0	1	0	1	0	0	0	0	4500	1725	60	0	2463	0	DHTKD1	10	12160750	Frame_Shift_Del	DEL	T	TCGA-CF-A1HS-01A-11D-A13W-08	655368	12160750	123373997	203	7833										
CUBN	8029	broad.mit.edu	37	chr10	16911847	16911847	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agggaaccacatcaaaatcaCtgaacctgtgaaatgtacct	7	10	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:16911847C>G	uc001ioo.2	-	59	9294	c.9242G>C	c.(9241-9243)AGT>ACT	p.S3081T	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.S437T	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3081	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATCAAAATCACTGAACCTGTG	0.413													0	0	0	0.001368	0	12	64										G	16911847	C	G	16911847	3	3	28	1	0	0	0	0	1	0	0	0	4051	565	20	4	1665	4	CUBN	10	16911847	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4751097	16911847	118622900	204	7834										
CSTF2T	23283	broad.mit.edu	37	chr10	53458275	53458275	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgggctccacttctccagtGactgaaagcaaagtccctcc	8	15	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:53458275G>C	uc001jjp.2	-	1	1081	c.1035C>G	c.(1033-1035)GTC>GTG	p.V345V	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	345	Gly-rich.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		CTTCTCCAGTGACTGAAAGCA	0.582													0	0	0	0.008871	0	20	73										C	53458275	G	C	53458275	2	2	28	1	0	0	0	0	0	0	0	1	3985	1277	45	1		1	CSTF2T	10	53458275	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	36546428	53458275	82076472	205	7835										
MYST4	23522	broad.mit.edu	37	chr10	76781861	76781861	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aggaggacgaggaggaggaaGaagaggaggaagaagaggaa	21	1	0	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:76781861G>C	uc001jwn.1	+	16	3737	c.3244G>C	c.(3244-3246)GAA>CAA	p.E1082Q	MYST4_uc001jwm.1_Missense_Mutation_p.E790Q|MYST4_uc001jwo.1_Missense_Mutation_p.E790Q|MYST4_uc001jwp.1_Missense_Mutation_p.E899Q	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1082	Poly-Glu.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					ggaggaggaagaagaggagga	0.274			T	CREBBP	AML						OREG0020273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	67										C	76781861	G	C	76781861	3	2	28	1	0	0	0	0	1	0	0	0	10105	943	33	1	3298	1	MYST4	10	76781861	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	23323586	76781861	58752886	206	7836										
CYP26A1	1592	broad.mit.edu	37	chr10	94836385	94836385	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acatcgggtgtgttattaagGagacccttcgactgaatccc	10	10	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:94836385G>C	uc001kil.2	+	6	1129	c.1084G>C	c.(1084-1086)GAG>CAG	p.E362Q	CYP26A1_uc001kik.1_Missense_Mutation_p.E293Q|CYP26A1_uc001kim.1_Missense_Mutation_p.E260Q	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	362					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				TGTTATTAAGGAGACCCTTCG	0.388													0	0	0	0.00278	0	22	77										C	94836385	G	C	94836385	3	2	28	1	0	0	0	0	1	0	0	0	4155	1175	41	1	1106	1	CYP26A1	10	94836385	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	18054524	94836385	40698362	207	7837										
TCTN3	26123	broad.mit.edu	37	chr10	97446269	97446269	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tacctccatattctgtggatCagtcatgcttcttggaacct	7	11	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:97446269C>G	uc001klb.3	-	7	1115	c.871G>C	c.(871-873)GAT>CAT	p.D291H	TCTN3_uc001kla.3_Missense_Mutation_p.D140H|TCTN3_uc010qoi.1_Missense_Mutation_p.D212H|TCTN3_uc001kld.2_Missense_Mutation_p.D309H|TCTN3_uc009xux.1_Missense_Mutation_p.D140H|TCTN3_uc009xuy.1_RNA	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	291	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		TTCTGTGGATCAGTCATGCTT	0.398													0	0	0	0.00245	0	14	155										G	97446269	C	G	97446269	3	3	28	1	0	0	0	0	1	0	0	0	15721	826	29	1	984	1	TCTN3	10	97446269	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2609884	97446269	38088478	208	7838										
CC2D2B	387707	broad.mit.edu	37	chr10	97775978	97775978	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cactgcatcagtttagctatCggaaataaggaggagcatgc	11	8	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:97775978C>T	uc001kll.2	+	6	628	c.429C>T	c.(427-429)ATC>ATT	p.I143I	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Silent_p.I143I	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	143										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		GTTTAGCTATCGGAAATAAGG	0.418													0	0	0	0.004007	0	15	51										T	97775978	C	T	97775978	2	4	28	1	0	0	0	0	0	0	0	1	2729	874	31	1		1	CC2D2B	10	97775978	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	329709	97775978	37758769	209	7839										
SEC31B	25956	broad.mit.edu	37	chr10	102265919	102265919	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccgagggcaccactgcacatCaaagcaccagctgctctgtg	10	15	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:102265919C>G	uc001krc.1	-	9	1024	c.922G>C	c.(922-924)GAT>CAT	p.D308H	SEC31B_uc010qpo.1_Missense_Mutation_p.D307H|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_5'UTR|SEC31B_uc010qpp.1_Missense_Mutation_p.D311H|SEC31B_uc009xwn.1_Missense_Mutation_p.D308H|SEC31B_uc009xwo.1_Missense_Mutation_p.D308H|SEC31B_uc010qpq.1_Missense_Mutation_p.D151H	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	308	WD 6.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CACTGCACATCAAAGCACCAG	0.517													0	0	0	0.000978	0	12	98										G	102265919	C	G	102265919	3	3	28	1	0	0	0	0	1	0	0	0	13999	826	29	1	2689	1	SEC31B	10	102265919	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4489941	102265919	33268828	210	7840										
FAM178A	55719	broad.mit.edu	37	chr10	102676898	102676898	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaacgagaactaaagaggttGagaaaggagcaaatggagca	14	4	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:102676898G>C	uc001krt.3	+	3	1298	c.756G>C	c.(754-756)TTG>TTC	p.L252F	FAM178A_uc001krr.1_Missense_Mutation_p.L252F|FAM178A_uc001krs.2_Missense_Mutation_p.L252F|FAM178A_uc001kru.1_Missense_Mutation_p.L188F	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	252											0						TAAAGAGGTTGAGAAAGGAGC	0.438													0	0	0	0.001855	0	12	76										C	102676898	G	C	102676898	3	2	28	1	0	0	0	0	1	0	0	0	5503	1281	45	1	766	1	FAM178A	10	102676898	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	410979	102676898	32857849	211	7841										
GBF1	8729	broad.mit.edu	37	chr10	104139673	104139673	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgcagatgtgggtgggatgGaggagacccggatgagggct	20	6	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:104139673G>C	uc001kux.1	+	36	5077	c.4837G>C	c.(4837-4839)GAG>CAG	p.E1613Q	GBF1_uc001kuy.1_Missense_Mutation_p.E1609Q|GBF1_uc001kuz.1_Missense_Mutation_p.E1610Q	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1613					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GGGTGGGATGGAGGAGACCCG	0.547													0	0	0	0.001984	0	6	32										C	104139673	G	C	104139673	3	2	28	1	0	0	0	0	1	0	0	0	6271	1175	41	1	4975	1	GBF1	10	104139673	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1462775	104139673	31395074	212	7842										
SH3PXD2A	9644	broad.mit.edu	37	chr10	105495508	105495508	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acccggcagtattcatcgatGggcttcagtctcttcacagc	9	13	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:105495508G>T	uc001kxj.1	-	4	428	c.288C>A	c.(286-288)CCC>CCA	p.P96P	SH3PXD2A_uc010qqu.1_Silent_p.P26P	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	96	PX.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ATTCATCGATGGGCTTCAGTC	0.582													1	0	4.67007e-22	0.00874	5.20557e-22	25	112										T	105495508	G	T	105495508	2	4	28	1	0	0	0	0	0	0	0	1	14256	1335	47	4		4	SH3PXD2A	10	105495508	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1355835	105495508	30039239	213	7843										
GRK5	2869	broad.mit.edu	37	chr10	121156215	121156215	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttctgttttaggcagaataTgaagttactccagatgaaaa	8	6	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:121156215T>A	uc001led.2	+	4	503	c.270T>A	c.(268-270)TAT>TAA	p.Y90*	GRK5_uc009xzh.2_5'UTR|GRK5_uc010qta.1_5'UTR	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	90	N-terminal.|RGS.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		AGGCAGAATATGAAGTTACTC	0.333													0	0	0	0.000602	0	4	87										A	121156215	T	A	121156215	4	1	28	1	0	0	0	0	0	1	0	0	6792	1471	51	5	284	5	GRK5	10	121156215	Nonsense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	15660707	121156215	14378532	214	7844										
INPP5F	22876	broad.mit.edu	37	chr10	121541205	121541205	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttggtgggcaaactcccaggAgaccatgaggtctgtaaagt	13	8	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr10:121541205A>G	uc001leo.2	+	3	403	c.237A>G	c.(235-237)GGA>GGG	p.G79G	INPP5F_uc001len.3_Silent_p.G79G	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	79							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		AACTCCCAGGAGACCATGAGG	0.423													0	0	0	0.006122	0	19	68										G	121541205	A	G	121541205	2	3	28	1	0	0	0	0	0	0	0	1	7758	291	11	5		5	INPP5F	10	121541205	Silent	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	384990	121541205	13993542	215	7845										
EPS8L2	64787	broad.mit.edu	37	chr11	721618	721618	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tggtttgtggcccggctgcaGaaggcagccgaggctttcaa	15	10	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:721618G>A	uc001lqt.2	+	10	1069	c.822G>A	c.(820-822)CAG>CAA	p.Q274Q	EPS8L2_uc010qwj.1_Silent_p.Q290Q|EPS8L2_uc001lqu.2_Silent_p.Q274Q|EPS8L2_uc010qwk.1_Silent_p.Q290Q|EPS8L2_uc001lqv.2_Silent_p.Q229Q|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'Flank|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	274						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCGGCTGCAGAAGGCAGCCG	0.557													0	0	0	0.001984	0	6	5										A	721618	G	A	721618	2	1	28	1	0	0	0	0	0	0	0	1	5196	933	33	1		1	EPS8L2	11	721618	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		721618	134284898	216	7846										
OR10A5	144124	broad.mit.edu	37	chr11	6867721	6867721	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctaaatcaaataattctcctGagagcaagaagttgttatca	6	7	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:6867721G>C	uc001met.1	+	1	808	c.808G>C	c.(808-810)GAG>CAG	p.E270Q		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TAATTCTCCTGAGAGCAAGAA	0.423													0	0	0	0.00361	0	59	171										C	6867721	G	C	6867721	3	2	28	1	0	0	0	0	1	0	0	0	10893	1291	45	1	810	1	OR10A5	11	6867721	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	6146103	6867721	128138795	217	7847										
LDHAL6A	160287	broad.mit.edu	37	chr11	18487256	18487256	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagaaaaaaggagaaacacGccttgatttagtccagcgaa	9	9	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:18487256G>A	uc001mop.1	+	4	578	c.317G>A	c.(316-318)CGC>CAC	p.R106H	LDHAL6A_uc001moq.2_Missense_Mutation_p.R106H	NM_001144071	NP_001137543	Q6ZMR3	LDH6A_HUMAN	lactate dehydrogenase A-like 6A	106		Substrate (By similarity).			glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	GGAGAAACACGCCTTGATTTA	0.388													0	0	0	0.006214	0	10	124										A	18487256	G	A	18487256	3	1	28	1	0	0	0	0	1	0	0	0	8699	1087	38	2	327	2	LDHAL6A	11	18487256	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	11619535	18487256	116519260	218	7848										
MYBPC3	4607	broad.mit.edu	37	chr11	47364473	47364473	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcctccaaggggcgcgtgatGagcacagggggctctgtcca	15	12	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:47364473G>A	uc001nfa.3	-	15	1420	c.1365C>T	c.(1363-1365)CTC>CTT	p.L455L	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	454	Ig-like C2-type 3.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GGCGCGTGATGAGCACAGGGG	0.632													0	0	0	0.004672	0	3	10										A	47364473	G	A	47364473	2	1	28	1	0	0	0	0	0	0	0	1	10013	1277	45	1		1	MYBPC3	11	47364473	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	28877217	47364473	87642043	219	7849										
OR5AK2	390181	broad.mit.edu	37	chr11	56756546	56756546	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttactcatcaacacagattCcagatttcaaacactcacgt	3	13	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:56756546C>G	uc010rjp.1	+	1	158	c.158C>G	c.(157-159)TCC>TGC	p.S53C		NM_001005323	NP_001005323	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						AACACAGATTCCAGATTTCAA	0.378													0	0	0	0.00361	0	79	57										G	56756546	C	G	56756546	3	3	28	1	0	0	0	0	1	0	0	0	11142	855	30	1	160	1	OR5AK2	11	56756546	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	9392073	56756546	78249970	220	7850										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57080263	57080263	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggctcaggggcatcagcaaaGagaacacagggctggtcagg	16	9	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:57080263G>A	uc001njr.2	-	4	2211	c.1899C>T	c.(1897-1899)CTC>CTT	p.L633L	TNKS1BP1_uc001njs.2_Silent_p.L633L|TNKS1BP1_uc009ymd.1_Silent_p.L84L	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	633	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CATCAGCAAAGAGAACACAGG	0.662													0	0	0	0.003163	0	10	24										A	57080263	G	A	57080263	2	1	28	1	0	0	0	0	0	0	0	1	16317	929	33	1		1	TNKS1BP1	11	57080263	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	323717	57080263	77926253	221	7851										
OR9Q1	219956	broad.mit.edu	37	chr11	57946980	57946980	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttgcattcactgaatatcctGaatgggcactccctctcttc	6	13	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:57946980G>A	uc001nmj.2	+	3	380	c.64G>A	c.(64-66)GAA>AAA	p.E22K		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TGAATATCCTGAATGGGCACT	0.453													0	0	0	0.008291	0	10	144										A	57946980	G	A	57946980	3	1	28	1	0	0	0	0	1	0	0	0	11255	1291	45	1	66	1	OR9Q1	11	57946980	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	866717	57946980	77059536	222	7852										
OR9Q2	219957	broad.mit.edu	37	chr11	57958572	57958572	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tggtgattattgtgtttgctCttttcgtcatgcctgcctgt	10	8	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:57958572C>G	uc010rka.1	+	1	610	c.610C>G	c.(610-612)CTT>GTT	p.L204V		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				TGTGTTTGCTCTTTTCGTCAT	0.473													0	0	0	0.004289	0	35	25										G	57958572	C	G	57958572	3	3	28	1	0	0	0	0	1	0	0	0	11256	913	32	1	612	1	OR9Q2	11	57958572	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	11592	57958572	77047944	223	7853										
NRXN2	9379	broad.mit.edu	37	chr11	64427940	64427940	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agggacacatcctctgcctcCgtgtgcatggcgttaggcag	13	12	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:64427940C>T	uc001oar.2	-	12	2692	c.2253G>A	c.(2251-2253)ACG>ACA	p.T751T	NRXN2_uc001oas.2_Silent_p.T720T|NRXN2_uc001oaq.2_Silent_p.T418T	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCTCTGCCTCCGTGTGCATGG	0.602													0	0	0	0.000602	0	5	35										T	64427940	C	T	64427940	2	4	28	1	0	0	0	0	0	0	0	1	10666	639	23	2		2	NRXN2	11	64427940	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	6469368	64427940	70578576	224	7854										
RASGRP2	10235	broad.mit.edu	37	chr11	64502637	64502637	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taagggaagttcccacggatGatctggaattcttcctgtga	11	8	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:64502637G>A	uc009ypu.2	-	12	1586	c.1359C>T	c.(1357-1359)ATC>ATT	p.I453I	RASGRP2_uc001oat.2_Silent_p.I355I|RASGRP2_uc001oau.2_Silent_p.I308I|RASGRP2_uc009ypv.2_Silent_p.I453I|RASGRP2_uc009ypw.2_Silent_p.I453I	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	453	EF-hand 1.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						TCCCACGGATGATCTGGAATT	0.557													0	0	0	0.003163	0	15	47										A	64502637	G	A	64502637	2	1	28	1	0	0	0	0	0	0	0	1	13075	1280	45	1		1	RASGRP2	11	64502637	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	74697	64502637	70503879	225	7855										
TIGD3	220359	broad.mit.edu	37	chr11	65124558	65124558	+	Frame_Shift_Del	DEL	C	C	-													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acagagagggtgcctttgagCccctgcccaccaaagctgat							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:65124558delC	uc001odo.3	+	2	1442	c.1279delC	c.(1279-1281)CCCfs	p.P427fs		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	427					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						TGCCTTTGAGCCCCTGCCCAC	0.562																		48	34	---	---								-	65124558	C	-	65124558	7	5	28	1	0	1	0	1	0	0	0	0	15894	739	26	0	1281	0	TIGD3	11	65124558	Frame_Shift_Del	DEL	C	TCGA-CF-A1HS-01A-11D-A13W-08	621921	65124558	69881958	226	7856										
KDM2A	22992	broad.mit.edu	37	chr11	67017821	67017821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccacagagcgcaccatggtaCgggaaaaggagaacaatccc	11	12	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:67017821C>T	uc001ojw.2	+	17	3184	c.2320C>T	c.(2320-2322)CGG>TGG	p.R774W	KDM2A_uc001ojx.2_Intron|KDM2A_uc001ojy.2_Missense_Mutation_p.R468W|KDM2A_uc010rpn.1_Missense_Mutation_p.R335W|KDM2A_uc001ojz.1_Missense_Mutation_p.R232W|KDM2A_uc001oka.2_5'Flank	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	774					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						CACCATGGTACGGGAAAAGGA	0.617													0	0	0	0.001984	0	7	24										T	67017821	C	T	67017821	3	4	28	1	0	0	0	0	1	0	0	0	8124	527	19	2	2382	2	KDM2A	11	67017821	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1893263	67017821	67988695	227	7857										
UBTFL1	642623	broad.mit.edu	37	chr11	89819393	89819393	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aagatgaacaaaagccaaaaAtacaggaacggtccagactt	8	8	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:89819393A>T	uc010rub.1	+	1	276	c.276A>T	c.(274-276)AAA>AAT	p.K92N		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	92					multicellular organismal development	cytoplasm|nucleus	DNA binding				0						AAAGCCAAAAATACAGGAACG	0.418													0	0	0	0.00333	0	23	18										T	89819393	A	T	89819393	3	4	28	1	0	0	0	0	1	0	0	0	16907	98	4	5	278	5	UBTFL1	11	89819393	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	22801572	89819393	45187123	228	7858										
BCL9L	283149	broad.mit.edu	37	chr11	118771774	118771774	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caggaggattggacgcagggGgcagaggcatgtggctgagc	20	7	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr11:118771774G>A	uc001pug.2	-	6	3643	c.2678C>T	c.(2677-2679)CCC>CTC	p.P893L	BCL9L_uc009zal.2_Missense_Mutation_p.P888L	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	893	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GGACGCAGGGGGCAGAGGCAT	0.602													0	0	0	0.00278	0	19	16										A	118771774	G	A	118771774	3	1	28	1	0	0	0	0	1	0	0	0	1382	1232	43	2	1833	2	BCL9L	11	118771774	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	28952381	118771774	16234742	229	7859										
KDM5A	5927	broad.mit.edu	37	chr12	420231	420231	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taagcgtaattgctgccactCtgaaaaaccaaagtagattc	7	9	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:420231C>G	uc001qif.1	-	21	3400	c.3037_splice	c.e21-1	p.S1013_splice	KDM5A_uc001qie.1_Splice_Site_p.S1013_splice|KDM5A_uc010sdn.1_Splice_Site_p.S972_splice	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1						chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TGCTGCCACTCTGAAAAACCA	0.418			T 	NUP98	AML								0	0	0	0.004672	0	3	36										G	420231	C	G	420231	5	3	28	1	0	0	0	0	0	0	1	0	8133	927	32	1	2068	1	KDM5A	12	420231	Splice_Site	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08		420231	133431664	230	7860										
CD163	9332	broad.mit.edu	37	chr12	7639982	7639982	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gattacagaggccacttgctCtgaaggacataatgaagcac	10	9	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:7639982C>T	uc001qsz.3	-	8	2151	c.2023G>A	c.(2023-2025)GAG>AAG	p.E675K	CD163_uc001qta.3_Missense_Mutation_p.E675K|CD163_uc009zfw.2_Missense_Mutation_p.E708K	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	675	SRCR 6.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GCCACTTGCTCTGAAGGACAT	0.468													0	0	0	0.000602	0	5	46										T	7639982	C	T	7639982	3	4	28	1	0	0	0	0	1	0	0	0	2967	922	32	1	1483	1	CD163	12	7639982	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7219751	7639982	126211913	231	7861										
A2M	2	broad.mit.edu	37	chr12	9268390	9268390	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agactgaggcgtctgtgggcAggaggaccaagaggagaaga	18	6	1	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:9268390A>G	uc001qvk.1	-	1	169	c.56T>C	c.(55-57)CTG>CCG	p.L19P	A2M_uc009zgk.1_5'UTR	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	19					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GTCTGTGGGCAGGAGGACCAA	0.468													0	0	0	0.001368	0	13	91										G	9268390	A	G	9268390	3	3	28	1	0	0	0	0	1	0	0	0	4	188	7	5	4512	5	A2M	12	9268390	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	1628408	9268390	124583505	232	7862										
GSG1	83445	broad.mit.edu	37	chr12	13256440	13256440	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttgagtcagttgagagggatCgctcattcactcttgcagcg	12	9	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:13256440C>G	uc001rbn.2	-	1	180	c.7G>C	c.(7-9)GAT>CAT	p.D3H	GSG1_uc001rbo.2_Missense_Mutation_p.D3H|GSG1_uc001rbp.2_Missense_Mutation_p.D3H|GSG1_uc001rbq.1_Missense_Mutation_p.D3H	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	Error:Variant_position_missing_in_Q2KHT4_after_alignment						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TGAGAGGGATCGCTCATTCAC	0.428													0	0	0	0.005443	0	26	232										G	13256440	C	G	13256440	3	3	28	1	0	0	0	0	1	0	0	0	6820	884	31	1	1246	1	GSG1	12	13256440	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	3988050	13256440	120595455	233	7863										
GUCY2C	2984	broad.mit.edu	37	chr12	14827597	14827597	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgaaagcatgagcaaatttgGgggtggtaatattttctcca	11	5	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:14827597G>T	uc001rcd.2	-	8	1183	c.1046C>A	c.(1045-1047)CCC>CAC	p.P349H	GUCY2C_uc009zhz.2_Missense_Mutation_p.P349H	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	349	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						AGCAAATTTGGGGGTGGTAAT	0.388													1	0	9.70103e-10	0.008291	1.056e-09	10	189										T	14827597	G	T	14827597	3	4	28	1	0	0	0	0	1	0	0	0	6896	1232	43	4	2255	4	GUCY2C	12	14827597	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1571157	14827597	119024298	234	7864										
EPS8	2059	broad.mit.edu	37	chr12	15803941	15803941	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gttcttttggccactctgctCtgcaggagggaatgaaggca	13	9	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:15803941C>T	uc009zif.2	-	14	1345	c.1251_splice	c.e14-1	p.R417_splice	EPS8_uc001rdb.2_Splice_Site_p.R417_splice|EPS8_uc009zig.2_Splice_Site_p.R157_splice|EPS8_uc010shv.1_Splice_Site_p.R157_splice	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway						cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		CCACTCTGCTCTGCAGGAGGG	0.448													0	0	0	0.001368	0	12	72										T	15803941	C	T	15803941	5	4	28	1	0	0	0	0	0	0	1	0	5194	927	32	1	1250	1	EPS8	12	15803941	Splice_Site	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	976344	15803941	118047954	235	7865										
SLCO1B3	28234	broad.mit.edu	37	chr12	21028199	21028199	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aataactcctaaggactctcGttgggttggagcttggtggc	13	8	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:21028199G>C	uc001rek.2	+	8	884	c.758G>C	c.(757-759)CGT>CCT	p.R253P	SLCO1B3_uc001rel.2_Missense_Mutation_p.R253P|SLCO1B3_uc010sil.1_Missense_Mutation_p.R253P|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.R78P	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	253	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AAGGACTCTCGTTGGGTTGGA	0.378													0	0	0	0.009718	0	42	272										C	21028199	G	C	21028199	3	2	28	1	0	0	0	0	1	0	0	0	14724	1145	40	4	784	4	SLCO1B3	12	21028199	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	5224258	21028199	112823696	236	7866										
ITPR2	3709	broad.mit.edu	37	chr12	26839539	26839539	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcccctgcctggcgttttttCtttgaagttggagggactcc	11	11	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:26839539C>G	uc001rhg.2	-	11	1440	c.1023G>C	c.(1021-1023)AAG>AAC	p.K341N		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	341	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GGCGTTTTTTCTTTGAAGTTG	0.413													0	0	0	0.001855	0	13	260										G	26839539	C	G	26839539	3	3	28	1	0	0	0	0	1	0	0	0	7921	912	32	1	7270	1	ITPR2	12	26839539	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5811340	26839539	107012356	237	7867										
C12orf35	55196	broad.mit.edu	37	chr12	32136793	32136794	+	Frame_Shift_Ins	INS	-	-	C													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gcacagatgtttcacataaaINSatatgtgatcagtcaaagtc							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:32136793_32136794insC	uc001rks.2	+	4	3318_3319	c.2904_2905insC	c.(2902-2907)AAAATAfs	p.K968fs		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	968_969										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			TTTCACATAAAATATGTGATCA	0.351																		10	115	---	---								C	32136794	-	C	32136793	7	5	28	1	0	1	1	0	0	0	0	0	1682	11	1	0	2906	0	C12orf35	12	32136793	Frame_Shift_Ins	INS	-	TCGA-CF-A1HS-01A-11D-A13W-08	5297254	32136793	101715102	238	7868										
BICD1	636	broad.mit.edu	37	chr12	32480490	32480490	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgacggagcagcatgagcgGgtgcaccggctcacagagca	15	12	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:32480490G>A	uc001rku.2	+	5	1182	c.1101G>A	c.(1099-1101)CGG>CGA	p.R367R	BICD1_uc001rkv.2_Silent_p.R367R|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	367	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AGCATGAGCGGGTGCACCGGC	0.612													0	0	0	0.00308	0	8	61										A	32480490	G	A	32480490	2	1	28	1	0	0	0	0	0	0	0	1	1428	1219	43	2		2	BICD1	12	32480490	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	343697	32480490	101371405	239	7869										
CNTN1	1272	broad.mit.edu	37	chr12	41337797	41337797	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttacatttaaaaatatatagAtcctacgcgaattatattgg	5	5	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:41337797A>G	uc001rmm.1	+	14	1621	c.1508A>G	c.(1507-1509)GAT>GGT	p.D503G	CNTN1_uc009zjy.1_Missense_Mutation_p.D503G|CNTN1_uc001rmn.1_Missense_Mutation_p.D492G|CNTN1_uc001rmo.2_Missense_Mutation_p.D503G	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	503					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane		p.D503H(1)		lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AAATATATAGATCCTACGCGA	0.338													0	0	0	0.001855	0	11	60										G	41337797	A	G	41337797	3	3	28	1	0	0	0	0	1	0	0	0	3640	347	12	5	1558	5	CNTN1	12	41337797	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	8857307	41337797	92514098	240	7870										
PLEKHA9	51054	broad.mit.edu	37	chr12	45567619	45567619	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggcattctggagagcaacttGagtctgatccagactgagac	12	9	2	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:45567619G>A	uc001rom.1	-	3	1067	c.530C>T	c.(529-531)TCA>TTA	p.S177L	PLEKHA9_uc009zke.2_Missense_Mutation_p.S177L	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		AGAGCAACTTGAGTCTGATCC	0.388													0	0	0	0.004482	0	7	182										A	45567619	G	A	45567619	3	1	28	1	0	0	0	0	1	0	0	0	12063	1294	45	1	649	1	PLEKHA9	12	45567619	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4229822	45567619	88284276	241	7871										
RND1	27289	broad.mit.edu	37	chr12	49258602	49258602	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	actaagctccaccctctgttCctctgtctccaaacaggctg	6	16	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:49258602C>T	uc001rsn.2	-	2	275	c.172G>A	c.(172-174)GAA>AAA	p.E58K		NM_014470	NP_055285	Q92730	RND1_HUMAN	GTP-binding protein RHO6 precursor	58					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			ovary(1)	1						ACCCTCTGTTCCTCTGTCTCC	0.507													0	0	0	0.00632	0	25	176										T	49258602	C	T	49258602	3	4	28	1	0	0	0	0	1	0	0	0	13419	864	30	1	542	1	RND1	12	49258602	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	3690983	49258602	84593293	242	7872										
SLC4A8	9498	broad.mit.edu	37	chr12	51845973	51845973	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atgaagagcatgtgcctcatGagctgtttacagagctggat	12	7	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:51845973G>T	uc001rys.1	+	4	521	c.343G>T	c.(343-345)GAG>TAG	p.E115*	SLC4A8_uc010sni.1_Nonsense_Mutation_p.E62*|SLC4A8_uc001rym.2_Nonsense_Mutation_p.E62*|SLC4A8_uc001ryn.2_Nonsense_Mutation_p.E62*|SLC4A8_uc001ryo.2_Nonsense_Mutation_p.E62*|SLC4A8_uc001ryp.1_Nonsense_Mutation_p.E62*|SLC4A8_uc010snj.1_Nonsense_Mutation_p.E142*|SLC4A8_uc001ryq.3_Nonsense_Mutation_p.E115*|SLC4A8_uc001ryr.2_Nonsense_Mutation_p.E115*|SLC4A8_uc010snk.1_Nonsense_Mutation_p.E62*	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	115	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGTGCCTCATGAGCTGTTTAC	0.478													1	0	3.59834e-05	0.001168	3.74155e-05	6	222										T	51845973	G	T	51845973	4	4	28	1	0	0	0	0	0	1	0	0	14659	1291	45	3	357	3	SLC4A8	12	51845973	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2587371	51845973	82005922	243	7873										
KRT6A	3853	broad.mit.edu	37	chr12	52882204	52882204	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agctcctggtactccttcagCagccgggccaggtcctgctt	11	15	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:52882204C>T	uc001sam.2	-	7	1541	c.1332G>A	c.(1330-1332)CTG>CTA	p.L444L		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	444	Rod.|Coil 2.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACTCCTTCAGCAGCCGGGCCA	0.612													0	0	0	0.002096	0	30	40										T	52882204	C	T	52882204	2	4	28	1	0	0	0	0	0	0	0	1	8480	697	25	2		2	KRT6A	12	52882204	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1036231	52882204	80969691	244	7874										
TCTN1	79600	broad.mit.edu	37	chr12	111064234	111064234	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	attttacagcaaacccacctCaaagagtatttgaacttgtt	5	9	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:111064234C>G	uc009zvs.2	+	3	517	c.409C>G	c.(409-411)CAA>GAA	p.Q137E	TCTN1_uc010syb.1_Missense_Mutation_p.Q137E|TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Missense_Mutation_p.Q77E|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Missense_Mutation_p.Q137E|TCTN1_uc001trn.3_Missense_Mutation_p.Q137E|TCTN1_uc001tri.2_Missense_Mutation_p.Q81E|TCTN1_uc001trj.1_Missense_Mutation_p.Q81E|TCTN1_uc001trk.3_RNA	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	137					multicellular organismal development	extracellular region					0						AAACCCACCTCAAAGAGTATT	0.313													0	0	0	0.00308	0	8	41										G	111064234	C	G	111064234	3	3	28	1	0	0	0	0	1	0	0	0	15719	827	29	1	519	1	TCTN1	12	111064234	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	58182030	111064234	22787661	245	7875										
C12orf51	283450	broad.mit.edu	37	chr12	112666449	112666449	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aagcatttaaaaatcaccttAcctctgatcttggaacacaa	4	10	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:112666449A>G	uc009zwc.2	-	35	5436	c.5418_splice	c.e35+1	p.E1806_splice	C12orf51_uc001ttr.1_5'Flank	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						AAATCACCTTACCTCTGATCT	0.403													0	0	0	0.004482	0	9	83										G	112666449	A	G	112666449	5	3	28	1	0	0	0	0	0	0	1	0	1696	405	14	5	6710	5	C12orf51	12	112666449	Splice_Site	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	1602215	112666449	21185446	246	7876										
TBX3	6926	broad.mit.edu	37	chr12	115115443	115115443	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttttgcaaaagggttgttgtCtatttttaactgggttatct	9	4	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:115115443C>G	uc001tvt.1	-	5	1847	c.883G>C	c.(883-885)GAC>CAC	p.D295H	TBX3_uc001tvu.1_Missense_Mutation_p.D275H	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	295	T-box; second part.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		GGGTTGTTGTCTATTTTTAAC	0.358													0	0	0	0.006122	0	16	125										G	115115443	C	G	115115443	3	3	28	1	0	0	0	0	1	0	0	0	15656	913	32	1	1364	1	TBX3	12	115115443	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	2448994	115115443	18736452	247	7877										
EP400	57634	broad.mit.edu	37	chr12	132475243	132475243	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aagaaggccttaaatttacaGaaagtttccaggagaggtag	11	5	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr12:132475243G>T	uc001ujn.2	+	8	2648	c.2613G>T	c.(2611-2613)CAG>CAT	p.Q871H	EP400_uc001ujl.2_Missense_Mutation_p.Q870H|EP400_uc001ujm.2_Missense_Mutation_p.Q871H|EP400_uc001ujj.1_Missense_Mutation_p.Q834H|EP400_uc001ujk.2_Missense_Mutation_p.Q907H	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	907					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TAAATTTACAGAAAGTTTCCA	0.393													1	0	1.49906e-05	0.00245	1.57044e-05	13	51										T	132475243	G	T	132475243	3	4	28	1	0	0	0	0	1	0	0	0	5149	933	33	3	2640	3	EP400	12	132475243	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	17359800	132475243	1376652	248	7878										
SACS	26278	broad.mit.edu	37	chr13	23915126	23915126	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctactgtctattactgaaatAgaaagtcgcagatctgctgg	9	8	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:23915126A>G	uc001uon.2	-	10	3478	c.2889T>C	c.(2887-2889)TCT>TCC	p.S963S	SACS_uc001uoo.2_Silent_p.S816S|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	963					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTACTGAAATAGAAAGTCGCA	0.363													0	0	0	0.00333	0	25	91										G	23915126	A	G	23915126	2	3	28	1	0	0	0	0	0	0	0	1	13804	407	15	5		5	SACS	13	23915126	Silent	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08		23915126	91254752	249	7879										
KBTBD6	89890	broad.mit.edu	37	chr13	41705450	41705450	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccagaggtctgtcctgggctGagcagctagatagatgtcat	13	9	2	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:41705450G>A	uc001uxu.1	-	1	1487	c.1198C>T	c.(1198-1200)CAG>TAG	p.Q400*	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Nonsense_Mutation_p.Q334*|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	400	Kelch 1.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		GTCCTGGGCTGAGCAGCTAGA	0.502													0	0	0	0.004289	0	34	156										A	41705450	G	A	41705450	4	1	28	1	0	0	0	0	0	1	0	0	7997	1299	45	1	830	1	KBTBD6	13	41705450	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	17790324	41705450	73464428	250	7880										
NEK5	341676	broad.mit.edu	37	chr13	52667254	52667254	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctcaactccagtattttcttGaggaatagggtgataacttg	9	7	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:52667254G>C	uc001vge.2	-	13	1284	c.1144C>G	c.(1144-1146)CAA>GAA	p.Q382E	NEK5_uc001vgf.2_Missense_Mutation_p.Q382E	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	382							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GTATTTTCTTGAGGAATAGGG	0.418													0	0	0	0.009718	0	44	126										C	52667254	G	C	52667254	3	2	28	1	0	0	0	0	1	0	0	0	10327	1299	45	1	1022	1	NEK5	13	52667254	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10961804	52667254	62502624	251	7881										
KLF5	688	broad.mit.edu	37	chr13	73636553	73636553	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cacacctctgctgttccgcaGactgcagtgaaacaattcca	7	14	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:73636553G>A	uc001vje.2	+	2	1140	c.816G>A	c.(814-816)CAG>CAA	p.Q272Q	KLF5_uc001vjd.2_Silent_p.Q181Q	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	272					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CTGTTCCGCAGACTGCAGTGA	0.502													0	0	0	0.008871	0	21	93										A	73636553	G	A	73636553	2	1	28	1	0	0	0	0	0	0	0	1	8349	933	33	1		1	KLF5	13	73636553	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	20969299	73636553	41533325	252	7882										
MYCBP2	23077	broad.mit.edu	37	chr13	77825292	77825292	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcattgtctcttaccctccgGggactctgtctggccgtcca	9	15	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:77825292G>C	uc001vkf.2	-	16	2352	c.2261C>G	c.(2260-2262)CCC>CGC	p.P754R	MYCBP2_uc010aev.2_Missense_Mutation_p.P158R	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	754	Cys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTACCCTCCGGGGACTCTGTC	0.443													0	0	0	0.00308	0	8	65										C	77825292	G	C	77825292	3	2	28	1	0	0	0	0	1	0	0	0	10018	1232	43	4	11937	4	MYCBP2	13	77825292	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4188739	77825292	37344586	253	7883										
SLITRK6	84189	broad.mit.edu	37	chr13	86369424	86369424	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtaatctcgttaggttcataAacgatccttcttcaagaact	6	9	4	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:86369424A>C	uc001vll.1	-	2	1679	c.1220T>G	c.(1219-1221)TTT>TGT	p.F407C	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	407	Extracellular (Potential).|LRR 7.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TAGGTTCATAAACGATCCTTC	0.338													0	0	0	0.008361	0	30	101										C	86369424	A	C	86369424	3	2	28	1	0	0	0	0	1	0	0	0	14747	14	1	5	1309	5	SLITRK6	13	86369424	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	8544132	86369424	28800454	254	7884										
GPR180	160897	broad.mit.edu	37	chr13	95273419	95273419	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agtcagaatgaagaagtctcAaagcagacctctccagtggg	11	9	3	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:95273419A>G	uc001vly.2	+	6	902	c.824A>G	c.(823-825)CAA>CGA	p.Q275R	GPR180_uc001vlz.2_Missense_Mutation_p.Q174R|GPR180_uc010afi.2_Missense_Mutation_p.Q36R	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	275						integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AAGAAGTCTCAAAGCAGACCT	0.423													0	0	0	0.000602	0	5	188										G	95273419	A	G	95273419	3	3	28	1	0	0	0	0	1	0	0	0	6676	130	5	5	846	5	GPR180	13	95273419	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	8903995	95273419	19896459	255	7885										
ZIC2	7546	broad.mit.edu	37	chr13	100635308	100635308	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atccgcgtgcacacaggcgaGaaacccttcccctgcccctt	8	18	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr13:100635308G>C	uc001von.2	+	1	990	c.990G>C	c.(988-990)GAG>GAC	p.E330D		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	330					brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACACAGGCGAGAAACCCTTCC	0.607													0	0	0	0.000602	0	5	114										C	100635308	G	C	100635308	3	2	28	1	0	0	0	0	1	0	0	0	17676	933	33	1	992	1	ZIC2	13	100635308	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	5361889	100635308	14534570	256	7886										
OR6S1	341799	broad.mit.edu	37	chr14	21108987	21108987	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaggcatagatgaatggattCaacagtggtgtcacaaatgt	11	5	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:21108987C>G	uc001vxv.1	-	1	864	c.864G>C	c.(862-864)TTG>TTC	p.L288F		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		TGAATGGATTCAACAGTGGTG	0.443													0	0	0	0.001168	0	6	238										G	21108987	C	G	21108987	3	3	28	1	0	0	0	0	1	0	0	0	11209	825	29	1	135	1	OR6S1	14	21108987	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08		21108987	86240553	257	7887										
GZMB	3002	broad.mit.edu	37	chr14	25101100	25101100	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttaatctctgggtcccccacGcacaactcaatggtactgtc	7	14	2	0	rs149659869	by1000genomes	TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:25101100G>A	uc001wps.2	-	4	630	c.564C>T	c.(562-564)TGC>TGT	p.C188C	GZMB_uc010ama.2_Silent_p.C176C|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	188	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		GGTCCCCCACGCACAACTCAA	0.458													0	0	0	0.001168	0	6	244										A	25101100	G	A	25101100	2	1	28	1	0	0	0	0	0	0	0	1	6916	1079	38	2		2	GZMB	14	25101100	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3992113	25101100	82248440	258	7888										
INSM2	84684	broad.mit.edu	37	chr14	36003540	36003540	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttgcggagcgtgtcttccctCtgctggggccccagggggcg	17	13	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:36003540C>G	uc001wth.1	+	1	293	c.82C>G	c.(82-84)CTG>GTG	p.L28V		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		TGTCTTCCCTCTGCTGGGGCC	0.687													0	0	0	0.003163	0	14	32										G	36003540	C	G	36003540	3	3	28	1	0	0	0	0	1	0	0	0	7772	912	32	1	84	1	INSM2	14	36003540	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10902440	36003540	71346000	259	7889										
GNG2	54331	broad.mit.edu	37	chr14	52433361	52433361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgacccctgttccggcttcaGaaaacccgtttagggagaag	11	11	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:52433361G>C	uc001wzi.2	+	4	701	c.172G>C	c.(172-174)GAA>CAA	p.E58Q	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_RNA|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Missense_Mutation_p.E58Q	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	58					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	TCCGGCTTCAGAAAACCCGTT	0.522													0	0	0	0.00361	0	75	112										C	52433361	G	C	52433361	3	2	28	1	0	0	0	0	1	0	0	0	6527	943	33	1	178	1	GNG2	14	52433361	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	16429821	52433361	54916179	260	7890										
GPR135	64582	broad.mit.edu	37	chr14	59930507	59930507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tttaggctgtttggtcactgCcgtcaccggctctggtggtc	13	11	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:59930507C>T	uc010apj.2	-	1	1553	c.1438G>A	c.(1438-1440)GCA>ACA	p.A480T	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	480	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)		TTGGTCACTGCCGTCACCGGC	0.547													0	0	0	0.00308	0	7	20										T	59930507	C	T	59930507	3	4	28	1	0	0	0	0	1	0	0	0	6644	739	26	2	50	2	GPR135	14	59930507	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7497146	59930507	47419033	261	7891										
VASH1	22846	broad.mit.edu	37	chr14	77242312	77242313	+	Missense_Mutation	DNP	GC	GC	AT													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttctcagggaactacttccGccacatcgtgctgggggtga							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:77242312_77242313GC>AT	uc001xst.2	+	5	1538_1539	c.608_609GC>AT	c.(607-609)CGC>CAT	p.R203H		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	203					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		AACTACTTCCGCCACATCGTGC	0.629													0	0	0	0.004672	0	3	7										AT	77242313	GC	AT	77242312	3	1	28	1	0	0	0	0	1	0	0	0	17122	1087	38	2	626	2	VASH1	14	77242312	Missense_Mutation	DNP	GC	TCGA-CF-A1HS-01A-11D-A13W-08	17311805	77242312	30107228	262	7892										
BRF1	2972	broad.mit.edu	37	chr14	105707692	105707692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagggcagtcatggacacctCgtggttcttctccccgaatt	10	13	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr14:105707692C>T	uc001yqp.2	-	6	967	c.604G>A	c.(604-606)GAG>AAG	p.E202K	BRF1_uc010tyo.1_Missense_Mutation_p.E87K|BRF1_uc010typ.1_Missense_Mutation_p.E87K|BRF1_uc001yql.2_5'UTR|BRF1_uc001yqo.2_Intron|BRF1_uc010axg.1_Missense_Mutation_p.E175K|BRF1_uc001yqn.2_RNA|BRF1_uc010axh.1_RNA|BRF1_uc010axj.1_Intron	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	202	2.				positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		ATGGACACCTCGTGGTTCTTC	0.637													0	0	0	0.004007	0	16	41										T	105707692	C	T	105707692	3	4	28	1	0	0	0	0	1	0	0	0	1510	893	31	1	1481	1	BRF1	14	105707692	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	28465380	105707692	1641848	263	7893										
CYFIP1	23191	broad.mit.edu	37	chr15	22980128	22980128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	taccattttctcaggaatttCaaagagataagcagcctaat	6	8	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:22980128C>G	uc001yus.2	+	23	2730	c.2626C>G	c.(2626-2628)CAA>GAA	p.Q876E	CYFIP1_uc001yut.2_Missense_Mutation_p.Q876E|CYFIP1_uc010aya.1_Missense_Mutation_p.Q904E|CYFIP1_uc001yuu.2_Missense_Mutation_p.Q445E|CYFIP1_uc001yuv.2_Missense_Mutation_p.Q70E	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	876					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TCAGGAATTTCAAAGAGATAA	0.358													0	0	0	0.00245	0	14	151										G	22980128	C	G	22980128	3	3	28	1	0	0	0	0	1	0	0	0	4137	827	29	1	3093	1	CYFIP1	15	22980128	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08		22980128	79551264	264	7894										
BAHD1	22893	broad.mit.edu	37	chr15	40758317	40758317	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cgccacgggcgcatccttaaGaacccccagtagcctcctca	8	18	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:40758317G>C	uc001zlu.2	+	7	2402	c.2331G>C	c.(2329-2331)AAG>AAC	p.K777N	BAHD1_uc001zlt.2_Missense_Mutation_p.K776N|BAHD1_uc010bbp.1_Missense_Mutation_p.K773N|BAHD1_uc001zlv.2_Missense_Mutation_p.K774N	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	777	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GCATCCTTAAGAACCCCCAGT	0.627													0	0	0	0.010504	0	15	43										C	40758317	G	C	40758317	3	2	28	1	0	0	0	0	1	0	0	0	1297	933	33	1	2353	1	BAHD1	15	40758317	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	17778189	40758317	61773075	265	7895										
RPAP1	26015	broad.mit.edu	37	chr15	41817271	41817271	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gctcagcatctcagcttcctCtgggggcaaggccagttctt	11	13	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:41817271C>T	uc001zod.2	-	15	2117	c.1993G>A	c.(1993-1995)GAG>AAG	p.E665K	RPAP1_uc001zoc.2_5'Flank	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	665						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TCAGCTTCCTCTGGGGGCAAG	0.617													0	0	0	0.004289	0	34	16										T	41817271	C	T	41817271	3	4	28	1	0	0	0	0	1	0	0	0	13541	922	32	1	2232	1	RPAP1	15	41817271	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1058954	41817271	60714121	266	7896										
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42138489	42138489	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttcaccgatcttctgacgtgGcgtccactggcccaggccac	10	16	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:42138489G>T	uc010bco.2	+	17	1790	c.1689G>T	c.(1687-1689)TGG>TGT	p.W563C	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.W794C|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.W794C|JMJD7-PLA2G4B_uc001zoq.3_Missense_Mutation_p.W264C|JMJD7-PLA2G4B_uc001zor.1_3'UTR	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	563	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						TTCTGACGTGGCGTCCACTGG	0.522													1	0	0.00198382	0.001984	0.00203743	6	89										T	42138489	G	T	42138489	3	4	28	1	0	0	0	0	1	0	0	0	7955	1212	42	4	2468	4	JMJD7-PLA2G4B	15	42138489	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	321218	42138489	60392903	267	7897										
UBR1	197131	broad.mit.edu	37	chr15	43339472	43339472	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtgttgcccaacctgtcttcGgatttcttccattccctgca	7	14	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:43339472G>A	uc001zqq.2	-	14	1621	c.1555C>T	c.(1555-1557)CGA>TGA	p.R519*	UBR1_uc010udk.1_Nonsense_Mutation_p.R519*	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	519					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ACCTGTCTTCGGATTTCTTCC	0.423													0	0	0	0.006214	0	9	234										A	43339472	G	A	43339472	4	1	28	1	0	0	0	0	0	1	0	0	16898	1124	39	2	3830	2	UBR1	15	43339472	Nonsense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1200983	43339472	59191920	268	7898										
UNC13C	440279	broad.mit.edu	37	chr15	54435219	54435219	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctgattctctttcagatagCagttctgtggatgaaaaggt	10	7	3	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:54435219C>T	uc002ack.2	+	2	2988	c.2988C>T	c.(2986-2988)AGC>AGT	p.S996S		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	996					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTTCAGATAGCAGTTCTGTGG	0.313													0	0	0	0.001368	0	10	83										T	54435219	C	T	54435219	2	4	28	1	0	0	0	0	0	0	0	1	16983	709	25	2		2	UNC13C	15	54435219	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	11095747	54435219	48096173	269	7899										
DIS3L	115752	broad.mit.edu	37	chr15	66621672	66621672	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aagataagaaaatggaaattAagggaaatctgttcagcaac	9	4	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:66621672A>G	uc010ujm.1	+	14	2485	c.2470A>G	c.(2470-2472)AAG>GAG	p.K824E	DIS3L_uc002app.2_Missense_Mutation_p.K741E|DIS3L_uc010bho.2_Missense_Mutation_p.K690E	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	824					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						AATGGAAATTAAGGGAAATCT	0.333													0	0	0	0.001984	0	7	64										G	66621672	A	G	66621672	3	3	28	1	0	0	0	0	1	0	0	0	4536	363	13	5	2524	5	DIS3L	15	66621672	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	12186453	66621672	35909720	270	7900										
CCDC33	80125	broad.mit.edu	37	chr15	74573023	74573023	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccacagtgaaaggcagccagCcgtggaccctcaaccagccc	10	17	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:74573023C>G	uc002axo.2	+	9	1298	c.904C>G	c.(904-906)CCG>GCG	p.P302A	CCDC33_uc002axp.2_Missense_Mutation_p.P124A	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	505							protein binding			ovary(3)|skin(2)	5						AGGCAGCCAGCCGTGGACCCT	0.582													0	0	0	0.001984	0	7	67										G	74573023	C	G	74573023	3	3	28	1	0	0	0	0	1	0	0	0	2806	739	26	4	938	4	CCDC33	15	74573023	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7951351	74573023	27958369	271	7901										
LMAN1L	79748	broad.mit.edu	37	chr15	75116785	75116785	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcctgttctacctcctcattCagactgtaggcttcttcggc	7	14	4	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:75116785C>G	uc002ayt.1	+	13	1419	c.1417C>G	c.(1417-1419)CAG>GAG	p.Q473E	LMAN1L_uc010bke.1_Missense_Mutation_p.Q461E|CPLX3_uc002ayu.1_5'Flank	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	473	Helical; (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						CCTCCTCATTCAGACTGTAGG	0.597													0	0	0	0.00308	0	7	122										G	75116785	C	G	75116785	3	3	28	1	0	0	0	0	1	0	0	0	8837	827	29	1	1467	1	LMAN1L	15	75116785	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	543762	75116785	27414607	272	7902										
TMC3	342125	broad.mit.edu	37	chr15	81628953	81628953	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gaaacggaaatacttaccttCtaccatctgggcaacctttt	6	11	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:81628953C>G	uc002bgo.1	-	20	2200	c.2200G>C	c.(2200-2202)GAA>CAA	p.E734Q	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	734	Cytoplasmic (Potential).			E -> EGK (in Ref. 1; AAP78778).		integral to membrane				ovary(1)|liver(1)	2						TACTTACCTTCTACCATCTGG	0.214													0	0	0	0.001984	0	7	159										G	81628953	C	G	81628953	3	3	28	1	0	0	0	0	1	0	0	0	15983	922	32	1	1114	1	TMC3	15	81628953	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	6512168	81628953	20902439	273	7903										
KIF7	374654	broad.mit.edu	37	chr15	90172769	90172769	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tccagttccgagaaggcaatCtgctgctggtgctgctcctc	11	13	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr15:90172769C>G	uc002bof.2	-	17	3431	c.3354G>C	c.(3352-3354)CAG>CAC	p.Q1118H	KIF7_uc010upw.1_Missense_Mutation_p.Q604H|C15orf42_uc010upv.1_RNA	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1118	Potential.				microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			AGAAGGCAATCTGCTGCTGGT	0.622													0	0	0	0.00499	0	13	61										G	90172769	C	G	90172769	3	3	28	1	0	0	0	0	1	0	0	0	8309	912	32	1	689	1	KIF7	15	90172769	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	8543816	90172769	12358623	274	7904										
WDR24	84219	broad.mit.edu	37	chr16	737292	737292	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggccaggtggtggcggcactCtggccgccacttcacacggg	16	14	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:737292C>T	uc002ciz.1	-	3	1544	c.784G>A	c.(784-786)GAG>AAG	p.E262K	JMJD8_uc002ciw.1_5'Flank|JMJD8_uc002cix.1_5'Flank|JMJD8_uc002ciy.1_5'Flank	NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	348	WD 4.									ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				TGGCGGCACTCTGGCCGCCAC	0.617													0	0	0	0.001984	0	4	15										T	737292	C	T	737292	3	4	28	1	0	0	0	0	1	0	0	0	17278	922	32	1	1616	1	WDR24	16	737292	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08		737292	89617461	275	7905										
ZC3H7A	29066	broad.mit.edu	37	chr16	11855265	11855265	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaaaattacgtatgtacatcAaactgtaaaggcatttgttt	6	5	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:11855265A>G	uc002dbk.2	-	18	2514	c.2316T>C	c.(2314-2316)TTT>TTC	p.F772F	ZC3H7A_uc002dbi.2_5'Flank|ZC3H7A_uc002dbj.2_Intron|ZC3H7A_uc002dbl.2_Silent_p.F772F|ZC3H7A_uc002dbm.1_Silent_p.F682F	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	772	C3H1-type 2.					nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TATGTACATCAAACTGTAAAG	0.363													0	0	0	0.00333	0	22	197										G	11855265	A	G	11855265	2	3	28	1	0	0	0	0	0	0	0	1	17569	127	5	5		5	ZC3H7A	16	11855265	Silent	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	11117973	11855265	78499488	276	7906										
C16orf62	57020	broad.mit.edu	37	chr16	19693640	19693640	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acaacagcgatgagaaaatcCgcatctacacctgcgtcctg	8	13	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:19693640C>T	uc002dgn.1	+	28	2467	c.2455C>T	c.(2455-2457)CGC>TGC	p.R819C	C16orf62_uc002dgo.1_Missense_Mutation_p.R726C|C16orf62_uc002dgp.1_Missense_Mutation_p.R568C	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	819						integral to membrane				ovary(1)	1						TGAGAAAATCCGCATCTACAC	0.532													0	0	0	0.004482	0	8	88										T	19693640	C	T	19693640	3	4	28	1	0	0	0	0	1	0	0	0	1825	652	23	2	2565	2	C16orf62	16	19693640	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7838375	19693640	70661113	277	7907										
ZNF319	57567	broad.mit.edu	37	chr16	58030577	58030577	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cgggcgtgcacgccctggtgCttgttgagatgctcccgctg	15	13	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:58030577C>G	uc002emx.1	-	2	2216	c.1593G>C	c.(1591-1593)AAG>AAC	p.K531N		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	531	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGCCCTGGTGCTTGTTGAGAT	0.637													0	0	0	0.009096	0	4	13										G	58030577	C	G	58030577	3	3	28	1	0	0	0	0	1	0	0	0	17834	796	28	4	159	4	ZNF319	16	58030577	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	38336937	58030577	32324176	278	7908										
CMTM2	146225	broad.mit.edu	37	chr16	66621981	66621981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cagaacccgccaagccaccaGaacctggcaagccaccaggg	10	17	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:66621981G>C	uc002ept.2	+	4	866	c.706G>C	c.(706-708)GAA>CAA	p.E236Q	CMTM2_uc010cdu.2_Missense_Mutation_p.E183Q	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	236					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		CAAGCCACCAGAACCTGGCAA	0.532													0	0	0	0.006214	0	4	75										C	66621981	G	C	66621981	3	2	28	1	0	0	0	0	1	0	0	0	3583	943	33	1	720	1	CMTM2	16	66621981	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	8591404	66621981	23732772	279	7909										
NAE1	8883	broad.mit.edu	37	chr16	66847711	66847711	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgtttggtgatatttatgcaGcgatcatcattaaatatatc	7	5	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:66847711G>C	uc002eqf.2	-	12	956	c.879C>G	c.(877-879)CGC>CGG	p.R293R	NAE1_uc002eqe.2_Silent_p.R287R|NAE1_uc002eqg.2_Silent_p.R204R|NAE1_uc010cdv.2_Silent_p.R296R	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	293					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TATTTATGCAGCGATCATCAT	0.308													0	0	0	0.000978	0	11	136										C	66847711	G	C	66847711	2	2	28	1	0	0	0	0	0	0	0	1	10139	958	34	4		4	NAE1	16	66847711	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	225730	66847711	23507042	280	7910										
FHOD1	29109	broad.mit.edu	37	chr16	67264128	67264128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agccacacctgagaacttctCtgtctggagaaagaagaagg	11	9	2	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:67264128C>G	uc002esl.2	-	20	3167	c.3055G>C	c.(3055-3057)GAG>CAG	p.E1019Q	FHOD1_uc002esk.2_Missense_Mutation_p.E78Q|FHOD1_uc010ced.2_Missense_Mutation_p.E826Q	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1019					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GAGAACTTCTCTGTCTGGAGA	0.592													0	0	0	0.001984	0	6	74										G	67264128	C	G	67264128	3	3	28	1	0	0	0	0	1	0	0	0	5882	922	32	1	451	1	FHOD1	16	67264128	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	416417	67264128	23090625	281	7911										
FAM65A	79567	broad.mit.edu	37	chr16	67578917	67578917	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttctgggaccagtgcacagaGagactcagctgcttcctctg	11	12	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:67578917G>T	uc010vjp.1	+	17	3084	c.2988G>T	c.(2986-2988)GAG>GAT	p.E996D	FAM65A_uc002eth.2_Missense_Mutation_p.E976D|FAM65A_uc010cej.2_Missense_Mutation_p.E979D|FAM65A_uc010vjq.1_Missense_Mutation_p.E990D|FAM65A_uc002etk.2_Missense_Mutation_p.E974D	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	980						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		AGTGCACAGAGAGACTCAGCT	0.642													1	0	2.27111e-07	0.001368	2.41558e-07	10	272										T	67578917	G	T	67578917	3	4	28	1	0	0	0	0	1	0	0	0	5599	933	33	3	2990	3	FAM65A	16	67578917	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	314789	67578917	22775836	282	7912										
PARD6A	50855	broad.mit.edu	37	chr16	67695398	67695398	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cttcgcgctgcctcgcgcttCggtgagcggcttccaggagt	14	14	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:67695398C>A	uc002ett.2	+	2	195	c.104C>A	c.(103-105)TCG>TAG	p.S35*	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Nonsense_Mutation_p.S35*|PARD6A_uc002etu.2_5'UTR	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	35	Interaction with PRKCI and PRKCZ.|OPR.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCTCGCGCTTCGGTGAGCGGC	0.657													1	0	1.15919e-05	0.008871	1.21744e-05	18	78										A	67695398	C	A	67695398	4	1	28	1	0	0	0	0	0	1	0	0	11445	893	31	3	110	3	PARD6A	16	67695398	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	116481	67695398	22659355	283	7913										
PARD6A	50855	broad.mit.edu	37	chr16	67696109	67696109	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atctcccgcctggtacgtggGggtctggctgagagtacagg	16	10	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:67696109G>C	uc002ett.2	+	3	691	c.600G>C	c.(598-600)GGG>GGC	p.G200G	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Silent_p.G199G|PARD6A_uc002etu.2_Silent_p.G24G	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	200	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TGGTACGTGGGGGTCTGGCTG	0.612													0	0	0	0.001368	0	9	83										C	67696109	G	C	67696109	2	2	28	1	0	0	0	0	0	0	0	1	11445	1219	43	4		4	PARD6A	16	67696109	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	711	67696109	22658644	284	7914										
MARVELD3	91862	broad.mit.edu	37	chr16	71668136	71668136	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gttctcctgaacttgctgatCctggcctgcagctctgtgtc	10	13	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:71668136C>T	uc002fat.2	+	3	699	c.636C>T	c.(634-636)ATC>ATT	p.I212I	MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 2	212	MARVEL.|Cytoplasmic (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				ACTTGCTGATCCTGGCCTGCA	0.527													0	0	0	0.00361	0	178	99										T	71668136	C	T	71668136	2	4	28	1	0	0	0	0	0	0	0	1	9319	845	30	1		1	MARVELD3	16	71668136	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	3972027	71668136	18686617	285	7915										
MBTPS1	8720	broad.mit.edu	37	chr16	84135448	84135448	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aatcacacttttttcttcttGattaaaagtgaatttttgtt	4	5	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:84135448G>C	uc002fhi.2	-	2	443	c.-59C>G	c.(-61--57)ATCAA>ATGAA			NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1						cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TTTTCTTCTTGATTAAAAGTG	0.348													0	0	0	0.001984	0	7	35										C	84135448	G	C	84135448	1	2	28	1	0	0	0	0	0	0	0	0	9361	1305	45	1		1	MBTPS1	16	84135448	Translation_Start_Site	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	12467312	84135448	6219305	286	7916										
ACSF3	197322	broad.mit.edu	37	chr16	89211739	89211739	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cggacctcagtggacatcatCaagactggaggctacaaggt	12	10	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr16:89211739C>G	uc002fmp.2	+	9	1771	c.1431C>G	c.(1429-1431)ATC>ATG	p.I477M	ACSF3_uc010cig.1_Missense_Mutation_p.I477M|ACSF3_uc010cih.1_Missense_Mutation_p.I212M|ACSF3_uc002fmq.1_RNA|ACSF3_uc010cii.1_RNA|ACSF3_uc002fmr.1_Missense_Mutation_p.I212M	NM_174917	NP_777577	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3 precursor	477					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0281)		TGGACATCATCAAGACTGGAG	0.622													0	0	0	0.00308	0	6	22										G	89211739	C	G	89211739	3	3	28	1	0	0	0	0	1	0	0	0	176	816	29	1	1457	1	ACSF3	16	89211739	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5076291	89211739	1143014	287	7917										
ANKFY1	51479	broad.mit.edu	37	chr17	4086740	4086740	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agcaggaagagtgcgctcttGctgtcctgccgctgtatggc	14	11	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:4086740G>C	uc002fxq.1	-	14	1943	c.1905C>G	c.(1903-1905)AGC>AGG	p.S635R	ANKFY1_uc002fxn.2_Missense_Mutation_p.S677R|ANKFY1_uc002fxo.2_Missense_Mutation_p.S635R|ANKFY1_uc002fxp.2_Missense_Mutation_p.S634R|ANKFY1_uc010ckp.2_Missense_Mutation_p.S576R	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	635	ANK 9.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						GTGCGCTCTTGCTGTCCTGCC	0.557													0	0	0	0.008291	0	10	50										C	4086740	G	C	4086740	3	2	28	1	0	0	0	0	1	0	0	0	626	1310	46	4	1655	4	ANKFY1	17	4086740	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		4086740	77108470	288	7918										
ZNF594	84622	broad.mit.edu	37	chr17	5086349	5086349	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tctttacattcatatggtttCtctcctgtatgagttacctg	6	9	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:5086349C>T	uc010cla.1	-	2	1359	c.1203G>A	c.(1201-1203)GAG>GAA	p.E401E		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						CATATGGTTTCTCTCCTGTAT	0.408													0	0	0	0.00499	0	17	303										T	5086349	C	T	5086349	2	4	28	1	0	0	0	0	0	0	0	1	18021	912	32	1		1	ZNF594	17	5086349	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	999609	5086349	76108861	289	7919										
TP53	7157	broad.mit.edu	37	chr17	7577121	7577122	+	Missense_Mutation	DNP	GC	GC	TT													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cccaggacaggcacaaacacGcacctcaaagctgttccgtc					rs121913343		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08			GC	TT	GC	GC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:7577121_7577122GC>TT	uc002gim.2	-	8	1010_1011	c.816_817GC>AA	c.(814-819)GTGCGT>GTAAGT	p.R273S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141S|TP53_uc010cng.1_Missense_Mutation_p.R141S|TP53_uc002gii.1_Missense_Mutation_p.R141S|TP53_uc010cnh.1_Missense_Mutation_p.R273S|TP53_uc010cni.1_Missense_Mutation_p.R273S|TP53_uc002gij.2_Missense_Mutation_p.R273S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.V272V(3)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.R273R(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAGC	0.54	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.004672	0	7	10										TT	7577122	GC	TT	7577121	3	4	28	1	0	0	0	0	1	0	0	0	16378	1087	38	4	469	4	TP53	17	7577121	Missense_Mutation	DNP	GC	TCGA-CF-A1HS-01A-11D-A13W-08	2490772	7577121	73618089	290	7920										
CHD3	1107	broad.mit.edu	37	chr17	7806657	7806657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttaccggtttgtgactcgcgCgtcagtggaagagcgaatca	13	9	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:7806657C>T	uc002gje.2	+	23	3713	c.3563C>T	c.(3562-3564)GCG>GTG	p.A1188V	CHD3_uc002gjd.2_Missense_Mutation_p.A1247V|CHD3_uc002gjf.2_Missense_Mutation_p.A1188V|CHD3_uc002gjh.2_5'Flank|SCARNA21_uc002gji.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1188	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GTGACTCGCGCGTCAGTGGAA	0.582													0	0	0	0.000602	0	4	54										T	7806657	C	T	7806657	3	4	28	1	0	0	0	0	1	0	0	0	3326	768	27	2	3934	2	CHD3	17	7806657	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	229536	7806657	73388553	291	7921										
MYH4	4622	broad.mit.edu	37	chr17	10351974	10351974	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcgctttagagtttcaagatGatccagggattcctcgtagg	11	8	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:10351974G>C	uc002gmn.2	-	32	4603	c.4492C>G	c.(4492-4494)CAT>GAT	p.H1498D	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1498	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTTCAAGATGATCCAGGGAT	0.428													0	0	0	0.006214	0	6	150										C	10351974	G	C	10351974	3	2	28	1	0	0	0	0	1	0	0	0	10037	1290	45	1	1363	1	MYH4	17	10351974	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2545317	10351974	70843236	292	7922										
AKAP10	11216	broad.mit.edu	37	chr17	19861601	19861601	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tccaatctcttatcaagagaAtcagttaaaaaagacgctgt	6	8	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:19861601A>T	uc002gwo.2	-	4	740	c.603T>A	c.(601-603)GAT>GAA	p.D201E	AKAP10_uc002gwp.1_Missense_Mutation_p.D201E|AKAP10_uc010cqw.1_Missense_Mutation_p.D201E|AKAP10_uc010vze.1_Missense_Mutation_p.D122E	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	201	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					TATCAAGAGAATCAGTTAAAA	0.408													0	0	0	0.001368	0	12	37										T	19861601	A	T	19861601	3	4	28	1	0	0	0	0	1	0	0	0	446	98	4	5	1433	5	AKAP10	17	19861601	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	9509627	19861601	61333609	293	7923										
ZNF207	7756	broad.mit.edu	37	chr17	30678830	30678830	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtaatagagattttgatgatGagaagatccttattcagcac	9	5	1	5			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:30678830G>A	uc002hhh.3	+	2	215	c.67G>A	c.(67-69)GAG>AAG	p.E23K	ZNF207_uc002hhj.3_Missense_Mutation_p.E23K|ZNF207_uc002hhi.3_Missense_Mutation_p.E23K|ZNF207_uc010csz.2_Missense_Mutation_p.E26K|ZNF207_uc002hhk.1_Missense_Mutation_p.E23K	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	23	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTTTGATGATGAGAAGATCCT	0.338													0	0	0	0.007413	0	18	616										A	30678830	G	A	30678830	3	1	28	1	0	0	0	0	1	0	0	0	17762	1291	45	1	73	1	ZNF207	17	30678830	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	10817229	30678830	50516380	294	7924										
MYO1D	4642	broad.mit.edu	37	chr17	31092057	31092057	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agatactactttgccattctCaataagaggcgtgtcaccat	7	10	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:31092057C>T	uc002hho.1	-	8	886	c.874G>A	c.(874-876)GAG>AAG	p.E292K	MYO1D_uc002hhp.1_Missense_Mutation_p.E292K|MYO1D_uc010wcb.1_Missense_Mutation_p.E292K	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	292	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			TTGCCATTCTCAATAAGAGGC	0.368													0	0	0	0.00308	0	7	350										T	31092057	C	T	31092057	3	4	28	1	0	0	0	0	1	0	0	0	10071	835	29	1	2206	1	MYO1D	17	31092057	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	413227	31092057	50103153	295	7925										
GHDC	84514	broad.mit.edu	37	chr17	40342704	40342704	+	Frame_Shift_Del	DEL	G	G	-													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cccccgcccactgccccactGcccggcccagggcctcagag							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:40342704delG	uc002hzd.2	-	7	1710	c.1226delC	c.(1225-1227)GCAfs	p.A409fs	GHDC_uc002hzg.1_Frame_Shift_Del_p.A409fs|GHDC_uc010wgg.1_Frame_Shift_Del_p.A370fs|GHDC_uc002hze.3_Frame_Shift_Del_p.A409fs|GHDC_uc002hzf.3_Frame_Shift_Del_p.A409fs	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	409						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CTGCCCCACTGCCCGGCCCAG	0.637																		20	22	---	---								-	40342704	G	-	40342704	7	5	28	1	0	1	0	1	0	0	0	0	6369	1319	46	0	467	0	GHDC	17	40342704	Frame_Shift_Del	DEL	G	TCGA-CF-A1HS-01A-11D-A13W-08	9250647	40342704	40852506	296	7926										
EZH1	2145	broad.mit.edu	37	chr17	40874816	40874816	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gagttcagtaccactaccttCttcaccatggactttcccat	5	14	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:40874816C>G	uc002iaz.2	-	6	629	c.484G>C	c.(484-486)GAA>CAA	p.E162Q	EZH1_uc002iba.2_Missense_Mutation_p.E153Q|EZH1_uc010wgt.1_Missense_Mutation_p.E92Q|EZH1_uc010wgu.1_Missense_Mutation_p.E168Q|EZH1_uc010wgv.1_Missense_Mutation_p.E122Q|EZH1_uc010wgw.1_Intron|EZH1_uc010cyp.2_Intron|EZH1_uc010cyq.2_Missense_Mutation_p.E79Q|EZH1_uc010cys.2_Missense_Mutation_p.E113Q|EZH1_uc010cyo.1_5'UTR|EZH1_uc010cyr.1_5'Flank	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	162					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		CCACTACCTTCTTCACCATGG	0.403													0	0	0	0.004672	0	3	95										G	40874816	C	G	40874816	3	3	28	1	0	0	0	0	1	0	0	0	5333	922	32	1	1823	1	EZH1	17	40874816	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	532112	40874816	40320394	297	7927										
EPN3	55040	broad.mit.edu	37	chr17	48618412	48618412	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggagcctccctggagacctCcgacacacctggtaagaaga	12	13	0	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:48618412C>T	uc002ira.3	+	7	1673	c.1238C>T	c.(1237-1239)TCC>TTC	p.S413F	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.S441F|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.S386F	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	413						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CTGGAGACCTCCGACACACCT	0.637													0	0	0	0.00499	0	15	16										T	48618412	C	T	48618412	3	4	28	1	0	0	0	0	1	0	0	0	5187	855	30	1	1260	1	EPN3	17	48618412	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7743596	48618412	32576798	298	7928										
APPBP2	10513	broad.mit.edu	37	chr17	58531675	58531675	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtttctaccttaaattttctCattgactgataaagtcttcc	4	9	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:58531675C>T	uc002iys.1	-	11	1614	c.1326G>A	c.(1324-1326)ATG>ATA	p.M442I	APPBP2_uc010ddl.1_Missense_Mutation_p.M371I	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	442	TPR 6.				intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TAAATTTTCTCATTGACTGAT	0.294													0	0	0	0.001168	0	5	139										T	58531675	C	T	58531675	3	4	28	1	0	0	0	0	1	0	0	0	816	826	29	1	443	1	APPBP2	17	58531675	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	9913263	58531675	22663535	299	7929										
BRIP1	83990	broad.mit.edu	37	chr17	59763273	59763273	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttaggacactgtagttcctgGacacatatctttgcttcatc	7	10	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:59763273G>A	uc002izk.1	-	19	2970	c.2829C>T	c.(2827-2829)GTC>GTT	p.V943V	BRIP1_uc002izl.1_Silent_p.V324V	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	943	Interaction with BRCA1.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						GTAGTTCCTGGACACATATCT	0.363			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00361	0	44	323										A	59763273	G	A	59763273	2	1	28	1	0	0	0	0	0	0	0	1	1514	1161	41	1		1	BRIP1	17	59763273	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1231598	59763273	21431937	300	7930										
BRIP1	83990	broad.mit.edu	37	chr17	59853848	59853848	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcccacttcatcttggaactCaaatgtttcagtattctgga	6	10	5	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:59853848C>G	uc002izk.1	-	14	2152	c.2011G>C	c.(2011-2013)GAG>CAG	p.E671Q	BRIP1_uc002izl.1_Missense_Mutation_p.E52Q	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	671					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						TCTTGGAACTCAAATGTTTCA	0.418			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00308	0	8	192										G	59853848	C	G	59853848	3	3	28	1	0	0	0	0	1	0	0	0	1514	835	29	1	1766	1	BRIP1	17	59853848	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	90575	59853848	21341362	301	7931										
MED13	9969	broad.mit.edu	37	chr17	60023934	60023934	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggtcacaggttagccaggaGagtgcattgtactgttccaa	13	8	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:60023934G>C	uc002izo.2	-	30	6497	c.6420C>G	c.(6418-6420)CTC>CTG	p.L2140L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2140					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TTAGCCAGGAGAGTGCATTGT	0.373													0	0	0	0.001984	0	7	85										C	60023934	G	C	60023934	2	2	28	1	0	0	0	0	0	0	0	1	9430	929	33	1		1	MED13	17	60023934	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	170086	60023934	21171276	302	7932										
AXIN2	8313	broad.mit.edu	37	chr17	63532561	63532561	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgaacaggtgggcacgggggGtggtgcgggggtgcccgctg	23	8	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:63532561G>T	uc002jfi.2	-	8	2307	c.2018C>A	c.(2017-2019)ACC>AAC	p.T673N	AXIN2_uc002jfh.2_Missense_Mutation_p.T608N	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	673					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						GGCACGGGGGGTGGTGCGGGG	0.682									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				1	0	0.000274275	0.004482	0.000283079	8	31										T	63532561	G	T	63532561	3	4	28	1	0	0	0	0	1	0	0	0	1237	1261	44	4	529	4	AXIN2	17	63532561	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3508627	63532561	17662649	303	7933										
RNF157	114804	broad.mit.edu	37	chr17	74152378	74152378	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgacgacaaggtgagattctCactttctggagtcacaccac	9	11	3	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:74152378C>T	uc002jqz.2	-	14	1507	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	RNF157_uc002jra.2_Missense_Mutation_p.E480K	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	480	Ser-rich.						zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			GTGAGATTCTCACTTTCTGGA	0.562													0	0	0	0.000978	0	10	60										T	74152378	C	T	74152378	3	4	28	1	0	0	0	0	1	0	0	0	13454	835	29	1	625	1	RNF157	17	74152378	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10619817	74152378	7042832	304	7934										
SLC25A10	1468	broad.mit.edu	37	chr17	79674028	79674028	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtggacaaagtgaagctgatCaaggaaatcaagaactacat	10	6	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:79674028C>G	uc010wut.1	+	4	563	c.438C>G	c.(436-438)ATC>ATG	p.I146M	MRPL12_uc002kbh.1_Missense_Mutation_p.I146M	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	Error:Variant_position_missing_in_Q9UBX3_after_alignment					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TGAAGCTGATCAAGGAAATCA	0.582													0	0	0	0.000602	0	5	54										G	79674028	C	G	79674028	3	3	28	1	0	0	0	0	1	0	0	0	14472	816	29	1		1	SLC25A10	17	79674028	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5521650	79674028	1521182	305	7935										
C17orf62	79415	broad.mit.edu	37	chr17	80403819	80403819	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaaacaaccttccctgtgctCttgtcgaagatggcttcctg	8	12	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr17:80403819C>G	uc002kez.2	-	4	267	c.219G>C	c.(217-219)AAG>AAC	p.K73N	C17orf62_uc002kex.2_5'Flank|C17orf62_uc002key.2_5'UTR|C17orf62_uc002kfa.2_Missense_Mutation_p.K73N|C17orf62_uc010dir.2_Missense_Mutation_p.K73N|C17orf62_uc002kfb.3_Missense_Mutation_p.K73N|C17orf62_uc002kfc.3_Missense_Mutation_p.K59N|C17orf62_uc002kfd.3_5'UTR|C17orf62_uc002kfe.3_5'UTR|C17orf62_uc010dis.1_Missense_Mutation_p.K73N	NM_001100407	NP_001093877	Q9BQA9	CQ062_HUMAN	hypothetical protein LOC79415 isoform a	73						integral to membrane	protein binding				0	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			TCCCTGTGCTCTTGTCGAAGA	0.607													0	0	0	0.004672	0	3	34										G	80403819	C	G	80403819	3	3	28	1	0	0	0	0	1	0	0	0	1870	912	32	1	356	1	C17orf62	17	80403819	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	729791	80403819	791391	306	7936										
NDC80	10403	broad.mit.edu	37	chr18	2599084	2599084	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aacttattcctaaaggtgctGagaattccaaaggttatgac	8	7	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr18:2599084G>C	uc002kli.2	+	12	1470	c.1288G>C	c.(1288-1290)GAG>CAG	p.E430Q		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	430	Interaction with the N-terminus of CDCA1.|Interaction with PSMC2 and SMC1A.|Interaction with NEK2 and ZWINT.|Interaction with SMC1A.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						TAAAGGTGCTGAGAATTCCAA	0.353													0	0	0	0.000978	0	12	78										C	2599084	G	C	2599084	3	2	28	1	0	0	0	0	1	0	0	0	10242	1291	45	1	1330	1	NDC80	18	2599084	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		2599084	75478164	307	7937										
MALT1	10892	broad.mit.edu	37	chr18	56402448	56402448	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tttaaggtgtcaaggagcagAagcttttgaaatccagcatt	10	6	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr18:56402448A>T	uc002lhm.1	+	13	1748	c.1490A>T	c.(1489-1491)GAA>GTA	p.E497V	MALT1_uc002lhn.1_Missense_Mutation_p.E486V	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	497	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						CAAGGAGCAGAAGCTTTTGAA	0.184			T	BIRC3	MALT								0	0	0	0.002299	0	23	33										T	56402448	A	T	56402448	3	4	28	1	0	0	0	0	1	0	0	0	9202	246	9	5	1540	5	MALT1	18	56402448	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	53803364	56402448	21674800	308	7938										
ZNF236	7776	broad.mit.edu	37	chr18	74593443	74593443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aaaaaagaaaaaaaaatgatAaagaagaagtcaccgtttct	6	4	2	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr18:74593443A>G	uc002lmi.2	+	9	1584	c.1386A>G	c.(1384-1386)ATA>ATG	p.I462M	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.I462M	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	462					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AAAAAATGATAAAGAAGAAGT	0.383													0	0	0	0.008871	0	20	16										G	74593443	A	G	74593443	3	3	28	1	0	0	0	0	1	0	0	0	17786	352	13	5	1420	5	ZNF236	18	74593443	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	18190995	74593443	3483805	309	7939										
CHAF1A	10036	broad.mit.edu	37	chr19	4409533	4409533	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggtggtcttgcaggacatctTggctgtgagaccaccgcaaa	13	10	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:4409533T>G	uc002mal.2	+	3	837	c.737T>G	c.(736-738)TTG>TGG	p.L246W		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	246	PxVxL motif.|Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGACATCTTGGCTGTGAGA	0.562								Chromatin_Structure					0	0	0	0.00308	0	7	32										G	4409533	T	G	4409533	3	3	28	1	0	0	0	0	1	0	0	0	3311	1821	63	5	747	5	CHAF1A	19	4409533	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08		4409533	54719450	310	7940										
FEM1A	55527	broad.mit.edu	37	chr19	4793524	4793524	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caccacaaacgtgggccgctAtcccgtgggcagattcccct	10	16	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:4793524A>G	uc002mbf.2	+	1	1797	c.1658A>G	c.(1657-1659)TAT>TGT	p.Y553C	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	553	ANK 8.				regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GTGGGCCGCTATCCCGTGGGC	0.632													0	0	0	0.004007	0	16	28										G	4793524	A	G	4793524	3	3	28	1	0	0	0	0	1	0	0	0	5809	449	16	5	1660	5	FEM1A	19	4793524	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	383991	4793524	54335459	311	7941										
ACTL9	284382	broad.mit.edu	37	chr19	8808755	8808755	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gggagcacgcgggctgcctcGccgatgaacgtctgcagccc	15	15	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:8808755G>C	uc002mkl.2	-	1	418	c.297C>G	c.(295-297)GGC>GGG	p.G99G		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	99						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						GGGCTGCCTCGCCGATGAACG	0.706													0	0	0	0.004672	0	3	18										C	8808755	G	C	8808755	2	2	28	1	0	0	0	0	0	0	0	1	203	1074	38	4		4	ACTL9	19	8808755	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	4015231	8808755	50320228	312	7942										
KRI1	65095	broad.mit.edu	37	chr19	10671688	10671688	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgagaactcaccagttccttCagggaatctgggttccgaat	10	10	3	1	rs140755508		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:10671688C>T	uc002moy.1	-	8	681	c.672G>A	c.(670-672)CTG>CTA	p.L224L	KRI1_uc002mow.1_5'Flank|KRI1_uc002mox.1_Silent_p.L220L	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	224	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCAGTTCCTTCAGGGAATCTG	0.547													0	0	0	0.002299	0	21	42										T	10671688	C	T	10671688	2	4	28	1	0	0	0	0	0	0	0	1	8444	813	29	1		1	KRI1	19	10671688	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1862933	10671688	48457295	313	7943										
PDE4C	5143	broad.mit.edu	37	chr19	18330071	18330071	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agttgctcctcctggtcagtCtggaccccaaagcgtgggac	12	13	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:18330071C>G	uc010xqc.1	-	8	1419	c.939G>C	c.(937-939)CAG>CAC	p.Q313H	PDE4C_uc002nik.3_Missense_Mutation_p.Q313H|PDE4C_uc002nil.3_Missense_Mutation_p.Q313H|PDE4C_uc002nif.3_Missense_Mutation_p.Q82H|PDE4C_uc002nig.3_Missense_Mutation_p.Q83H|PDE4C_uc002nih.3_Missense_Mutation_p.Q83H|PDE4C_uc010ebk.2_Missense_Mutation_p.Q207H|PDE4C_uc002nii.3_Missense_Mutation_p.Q281H|PDE4C_uc010ebl.2_Missense_Mutation_p.Q27H|PDE4C_uc010xqd.1_Missense_Mutation_p.Q82H	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	313					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	CCTGGTCAGTCTGGACCCCAA	0.622													0	0	0	0.004672	0	3	56										G	18330071	C	G	18330071	3	3	28	1	0	0	0	0	1	0	0	0	11641	912	32	1	1231	1	PDE4C	19	18330071	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	7658383	18330071	40798912	314	7944										
RYR1	6261	broad.mit.edu	37	chr19	39063871	39063871	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tggcccggaagctggagtttGatggcctgtacatcacggag	15	9	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:39063871G>C	uc002oit.2	+	96	14183	c.14053G>C	c.(14053-14055)GAT>CAT	p.D4685H	RYR1_uc002oiu.2_Missense_Mutation_p.D4680H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4685					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCTGGAGTTTGATGGCCTGTA	0.617													0	0	0	0.000602	0	5	92										C	39063871	G	C	39063871	3	2	28	1	0	0	0	0	1	0	0	0	13768	1290	45	1	14435	1	RYR1	19	39063871	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	20733800	39063871	20065112	315	7945										
EID2	163126	broad.mit.edu	37	chr19	40030087	40030087	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcagaggcagtcagagctatCgtaaaggttaaaatatcgag	11	6	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:40030087C>T	uc002oma.2	-	1	752	c.633G>A	c.(631-633)ACG>ACA	p.T211T		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	211					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TCAGAGCTATCGTAAAGGTTA	0.448													0	0	0	0.001168	0	6	230										T	40030087	C	T	40030087	2	4	28	1	0	0	0	0	0	0	0	1	4987	871	31	1		1	EID2	19	40030087	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	966216	40030087	19098896	316	7946										
LGALS13	29124	broad.mit.edu	37	chr19	40095312	40095312	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caaagggacaccaatccactCttttatgtgagtactccatg	7	11	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:40095312C>G	uc002omb.2	+	2	126	c.86C>G	c.(85-87)TCT>TGT	p.S29C		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	29	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CCAATCCACTCTTTTATGTGA	0.453													0	0	0	0.00361	0	106	140										G	40095312	C	G	40095312	3	3	28	1	0	0	0	0	1	0	0	0	8740	913	32	1	92	1	LGALS13	19	40095312	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	65225	40095312	19033671	317	7947										
ZNF780A	284323	broad.mit.edu	37	chr19	40582009	40582009	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atttctaaaataaaaggcctCaatgccaagagttgtactta	6	7	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:40582009C>G	uc002omy.2	-	6	565	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E114Q|ZNF780A_uc010xvh.1_Missense_Mutation_p.E115Q	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAAAAGGCCTCAATGCCAAGA	0.328													0	0	0	0.000978	0	11	245										G	40582009	C	G	40582009	3	3	28	1	0	0	0	0	1	0	0	0	18149	835	29	1	1716	1	ZNF780A	19	40582009	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	486697	40582009	18546974	318	7948										
C19orf47	126526	broad.mit.edu	37	chr19	40842021	40842021	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgggcacagcacccacctgaCggtgcaccactttggcatgc	11	15	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:40842021C>G	uc002oni.3	-	4	330	c.329G>C	c.(328-330)CGT>CCT	p.R110P	C19orf47_uc002ong.2_5'UTR|C19orf47_uc002onh.2_Missense_Mutation_p.R43P	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	110										ovary(1)|skin(1)	2			Lung(22;0.000636)			ACCCACCTGACGGTGCACCAC	0.547													0	0	0	0.004672	0	3	89										G	40842021	C	G	40842021	3	3	28	1	0	0	0	0	1	0	0	0	1930	536	19	4	963	4	C19orf47	19	40842021	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	260012	40842021	18286962	319	7949										
HIPK4	147746	broad.mit.edu	37	chr19	40886914	40886914	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cgttcgtgtgactcccaggtCagcatgcgcttgatcagctc	11	13	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:40886914C>T	uc002onp.2	-	3	1269	c.984G>A	c.(982-984)CTG>CTA	p.L328L		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	328	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			ACTCCCAGGTCAGCATGCGCT	0.647													0	0	0	0.009096	0	4	109										T	40886914	C	T	40886914	2	4	28	1	0	0	0	0	0	0	0	1	7119	813	29	1		1	HIPK4	19	40886914	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	44893	40886914	18242069	320	7950										
ZNF233	353355	broad.mit.edu	37	chr19	44778142	44778142	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aggaattctggtcttcaccaGagagttcacactggagagaa	11	8	4	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:44778142G>A	uc002oyz.1	+	5	1456	c.1329G>A	c.(1327-1329)CAG>CAA	p.Q443Q	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Silent_p.Q258Q	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	443					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GTCTTCACCAGAGAGTTCACA	0.428													0	0	0	0.004878	0	36	89										A	44778142	G	A	44778142	2	1	28	1	0	0	0	0	0	0	0	1	17783	933	33	1		1	ZNF233	19	44778142	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3891228	44778142	14350841	321	7951										
EML2	24139	broad.mit.edu	37	chr19	46117878	46117878	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctcaccaaacaccccaaaccCtaggacacaagtagctgtgg	7	15	1	0	rs35344004		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:46117878C>G	uc002pcn.2	-	17	1713	c.1678G>C	c.(1678-1680)GGG>CGG	p.G560R	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Missense_Mutation_p.G444R|EML2_uc010xxl.1_Missense_Mutation_p.G707R|EML2_uc010xxm.1_Missense_Mutation_p.G761R	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	560					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		ACCCCAAACCCTAGGACACAA	0.448													0	0	0	0.002522	0	42	155										G	46117878	C	G	46117878	3	3	28	1	0	0	0	0	1	0	0	0	5097	681	24	4	283	4	EML2	19	46117878	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1339736	46117878	13011105	322	7952										
HRC	3270	broad.mit.edu	37	chr19	49657670	49657670	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcatcctcttcaatcccgtgGccttggtgcctgtgagcctg	10	14	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:49657670G>T	uc002pmv.2	-	1	1012	c.825C>A	c.(823-825)GGC>GGA	p.G275G		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	275	2-5.|6 X approximate tandem repeats.|4 X tandem repeats, acidic.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CAATCCCGTGGCCTTGGTGCC	0.373													1	0	6.12954e-19	0.004656	6.79614e-19	27	44										T	49657670	G	T	49657670	2	4	28	1	0	0	0	0	0	0	0	1	7352	1190	42	4		4	HRC	19	49657670	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3539792	49657670	9471313	323	7953										
TRPM4	54795	broad.mit.edu	37	chr19	49692258	49692258	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agggctgcccgcctcctcctCcgtcgctgcccgctctgggg	13	19	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:49692258C>G	uc002pmw.2	+	14	2001	c.1929C>G	c.(1927-1929)CTC>CTG	p.L643L	TRPM4_uc010emu.2_Silent_p.L643L|TRPM4_uc010yak.1_Silent_p.L107L|TRPM4_uc002pmx.2_Silent_p.L469L|TRPM4_uc010emv.2_Silent_p.L528L|TRPM4_uc010yal.1_Silent_p.L289L|TRPM4_uc002pmy.2_5'UTR	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	643	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GCCTCCTCCTCCGTCGCTGCC	0.617													0	0	0	0.00361	0	43	83										G	49692258	C	G	49692258	2	3	28	1	0	0	0	0	0	0	0	1	16585	842	30	1		1	TRPM4	19	49692258	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	34588	49692258	9436725	324	7954										
ZNF616	90317	broad.mit.edu	37	chr19	52620235	52620235	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tttctcctgtattactgttcTctgttggtggtaattccttg	8	8	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:52620235T>C	uc002pym.2	-	4	465	c.182A>G	c.(181-183)GAG>GGG	p.E61G	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		ATTACTGTTCTCTGTTGGTGG	0.323													0	0	0	0.003163	0	14	232										C	52620235	T	C	52620235	3	2	28	1	0	0	0	0	1	0	0	0	18038	1551	54	5	2167	5	ZNF616	19	52620235	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	2927977	52620235	6508748	325	7955										
ZNF816A	125893	broad.mit.edu	37	chr19	53454831	53454831	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	actccatcatggattttaaaGagctatctaaaaaatataaa	4	6	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:53454831G>C	uc002qal.1	-	5	498	c.197C>G	c.(196-198)TCT>TGT	p.S66C	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.S50C	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		GGATTTTAAAGAGCTATCTAA	0.333													0	0	0	0.006999	0	41	86										C	53454831	G	C	53454831	3	2	28	1	0	0	0	0	1	0	0	0	18174	942	33	1	1762	1	ZNF816A	19	53454831	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	834596	53454831	5674152	326	7956										
LILRA5	353514	broad.mit.edu	37	chr19	54823808	54823808	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgaggcttccaatctcaccGaggcagagcagaaccatgag	11	12	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:54823808G>A	uc002qfe.2	-	2	207	c.87C>T	c.(85-87)CTC>CTT	p.L29L	LILRA5_uc002qff.2_Silent_p.L29L|LILRA5_uc010yev.1_Silent_p.L29L|LILRA5_uc010yew.1_Silent_p.L29L|LILRA5_uc002qfh.1_Silent_p.L29L|LILRA5_uc002qfg.1_Silent_p.L29L	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	29					innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAATCTCACCGAGGCAGAGCA	0.602													0	0	0	0.00333	0	24	19										A	54823808	G	A	54823808	2	1	28	1	0	0	0	0	0	0	0	1	8788	1072	37	1		1	LILRA5	19	54823808	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1368977	54823808	4305175	327	7957										
NLRP7	199713	broad.mit.edu	37	chr19	55451137	55451137	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aacagggccgcgttgctcctCattagctcaaaggcacgcat	10	13	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr19:55451137C>T	uc002qih.3	-	4	1126	c.1050G>A	c.(1048-1050)ATG>ATA	p.M350I	NLRP7_uc002qig.3_Missense_Mutation_p.M350I|NLRP7_uc002qii.3_Missense_Mutation_p.M350I|NLRP7_uc010esk.2_Missense_Mutation_p.M350I|NLRP7_uc010esl.2_Missense_Mutation_p.M378I	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	350	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CGTTGCTCCTCATTAGCTCAA	0.612													0	0	0	0.009096	0	4	48										T	55451137	C	T	55451137	3	4	28	1	0	0	0	0	1	0	0	0	10482	826	29	1	2095	1	NLRP7	19	55451137	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	627329	55451137	3677846	328	7958										
CPXM1	56265	broad.mit.edu	37	chr20	2777020	2777020	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ggcacaggaactgcatcaggAgcagaagcaactcccgcccc	11	15	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr20:2777020A>T	uc002wgu.2	-	9	1179	c.1115T>A	c.(1114-1116)CTC>CAC	p.L372H	CPXM1_uc010gas.2_Missense_Mutation_p.L372H	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	372	Poly-Leu.				cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						CTGCATCAGGAGCAGAAGCAA	0.642													0	0	0	0.008291	0	11	86										T	2777020	A	T	2777020	3	4	28	1	0	0	0	0	1	0	0	0	3837	304	11	5	1113	5	CPXM1	20	2777020	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08		2777020	60248500	329	7959										
PLAGL2	5326	broad.mit.edu	37	chr20	30784748	30784748	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gagggagctgagctggggaaGagataggtgaggattccaga	19	4	0	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr20:30784748G>C	uc002wxn.2	-	3	1215	c.998C>G	c.(997-999)TCT>TGT	p.S333C		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	333						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGCTGGGGAAGAGATAGGTGA	0.562													0	0	0	0.001168	0	5	227										C	30784748	G	C	30784748	3	2	28	1	0	0	0	0	1	0	0	0	12020	942	33	1	496	1	PLAGL2	20	30784748	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	28007728	30784748	32240772	330	7960										
PLCG1	5335	broad.mit.edu	37	chr20	39802821	39802821	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccctgcgggagcggggctcaGatgcctcaggccagctgttt	15	13	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr20:39802821G>C	uc002xjp.1	+	31	3821	c.3700G>C	c.(3700-3702)GAT>CAT	p.D1234H	PLCG1_uc002xjo.1_Missense_Mutation_p.D1235H|PLCG1_uc010zwe.1_Missense_Mutation_p.D900H	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1234					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GCGGGGCTCAGATGCCTCAGG	0.597													0	0	0	0.004482	0	9	76										C	39802821	G	C	39802821	3	2	28	1	0	0	0	0	1	0	0	0	12035	942	33	1	3825	1	PLCG1	20	39802821	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	9018073	39802821	23222699	331	7961										
RBPJL	11317	broad.mit.edu	37	chr20	43943062	43943062	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ttccattgcagatcatccgtAaagtagcaaaacagtgtgcg	9	9	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr20:43943062A>G	uc002xns.2	+	9	949	c.877A>G	c.(877-879)AAA>GAA	p.K293E	RBPJL_uc002xnt.2_Missense_Mutation_p.K293E	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	293	By similarity.				signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GATCATCCGTAAAGTAGCAAA	0.577													0	0	0	0.009096	0	4	163										G	43943062	A	G	43943062	3	3	28	1	0	0	0	0	1	0	0	0	13162	363	13	5	911	5	RBPJL	20	43943062	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	4140241	43943062	19082458	332	7962										
ZBP1	81030	broad.mit.edu	37	chr20	56186846	56186846	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gacgccgtggagcctcatctCattgctgtgtcccagctgca	11	14	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr20:56186846C>G	uc002xyo.2	-	6	1092	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	ZBP1_uc010gjm.2_Missense_Mutation_p.E270Q|ZBP1_uc002xyp.2_Missense_Mutation_p.E196Q	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	271	RIP homotypic interaction motif (RHIM) 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			AGCCTCATCTCATTGCTGTGT	0.632													0	0	0	0.000602	0	5	20										G	56186846	C	G	56186846	3	3	28	1	0	0	0	0	1	0	0	0	17518	835	29	1	490	1	ZBP1	20	56186846	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	12243784	56186846	6838674	333	7963										
NRIP1	8204	broad.mit.edu	37	chr21	16337647	16337647	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tctttttactgtcagccacaGagttacttctgtgcggggac	10	10	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:16337647G>C	uc002yjx.2	-	4	3465	c.2867C>G	c.(2866-2868)TCT>TGT	p.S956C		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	956					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GTCAGCCACAGAGTTACTTCT	0.418													0	0	0	0.00623	0	39	193										C	16337647	G	C	16337647	3	2	28	1	0	0	0	0	1	0	0	0	10652	942	33	1	613	1	NRIP1	21	16337647	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		16337647	31792248	334	7964			2	26		4	4	2574	N	G_C	4.580873e-06
NRIP1	8204	broad.mit.edu	37	chr21	16338392	16338392	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctggaggacagtacgtctttCaagcagattttctatttcag	9	8	4	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:16338392C>A	uc002yjx.2	-	4	2720	c.2122G>T	c.(2122-2124)GAA>TAA	p.E708*		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	708					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GTACGTCTTTCAAGCAGATTT	0.403													1	0	4.35082e-09	0.010504	4.69933e-09	20	108										A	16338392	C	A	16338392	4	1	28	1	0	0	0	0	0	1	0	0	10652	835	29	3	1358	3	NRIP1	21	16338392	Nonsense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	745	16338392	31791503	335	7965			2	26		4	4	2574	N	G_C	4.580873e-06
NRIP1	8204	broad.mit.edu	37	chr21	16340196	16340196	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tccttctttacgtttaaattCatgatagaatcagacagcct	5	9	3	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:16340196C>T	uc002yjx.2	-	4	916	c.318G>A	c.(316-318)ATG>ATA	p.M106I		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	106	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		CGTTTAAATTCATGATAGAAT	0.468													0	0	0	0.007413	0	18	140										T	16340196	C	T	16340196	3	4	28	1	0	0	0	0	1	0	0	0	10652	826	29	1	3162	1	NRIP1	21	16340196	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	1804	16340196	31789699	336	7966			2	26		4	4	2574	N	G_C	4.580873e-06
NRIP1	8204	broad.mit.edu	37	chr21	16340220	16340220	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atagaatcagacagcctcttCcgctttgctgcattccagtc	7	13	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:16340220C>T	uc002yjx.2	-	4	892	c.294G>A	c.(292-294)CGG>CGA	p.R98R		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	98	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ACAGCCTCTTCCGCTTTGCTG	0.458													0	0	0	0.004007	0	15	101										T	16340220	C	T	16340220	2	4	28	1	0	0	0	0	0	0	0	1	10652	842	30	1		1	NRIP1	21	16340220	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	24	16340220	31789675	337	7967			2	26		4	4	2574	N	G_C	4.580873e-06
JAM2	58494	broad.mit.edu	37	chr21	27062211	27062211	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgcaaaaccccaaagaagaCtgtttcctccagattagagt	7	11	0	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:27062211C>A	uc002ylp.1	+	3	712	c.167C>A	c.(166-168)ACT>AAT	p.T56N	JAM2_uc011ace.1_Missense_Mutation_p.T56N|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Intron|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.T56N|JAM2_uc010gli.1_Missense_Mutation_p.T56N	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	56	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						CCAAAGAAGACTGTTTCCTCC	0.393													1	0	2.35188e-11	0.006122	2.58707e-11	16	211										A	27062211	C	A	27062211	3	1	28	1	0	0	0	0	1	0	0	0	7943	565	20	4	177	4	JAM2	21	27062211	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10721991	27062211	21067684	338	7968										
BACH1	571	broad.mit.edu	37	chr21	30701862	30701862	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cactgtctcgaaatgattttCagtccttgttgaaaatgcac	7	9	2	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:30701862C>G	uc002ynj.2	+	4	1739	c.1624C>G	c.(1624-1626)CAG>GAG	p.Q542E	BACH1_uc002ynk.2_Missense_Mutation_p.Q542E|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	542						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2						AAATGATTTTCAGTCCTTGTT	0.343													0	0	0	0.008291	0	11	41										G	30701862	C	G	30701862	3	3	28	1	0	0	0	0	1	0	0	0	1283	827	29	1	1634	1	BACH1	21	30701862	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	3639651	30701862	17428033	339	7969										
DNAJC28	54943	broad.mit.edu	37	chr21	34860591	34860591	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atccagtttaaaaaacctttCttgatttcaggtgttttctc	5	8	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:34860591C>G	uc002yrv.2	-	2	1559	c.1110G>C	c.(1108-1110)AAG>AAC	p.K370N	DNAJC28_uc002yrw.2_Missense_Mutation_p.K370N	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	370				LIVPILTRQKVHFDAQKEIVRAQKIYETLIKTKEVTDRNPN NLDQGEGEKTPEIKKGFLNWMNLWKFIKIRSF -> CSHPD QAKSPF (in Ref. 2; BAA91185).			heat shock protein binding				0						AAAAACCTTTCTTGATTTCAG	0.318													0	0	0	0.010504	0	20	94										G	34860591	C	G	34860591	3	3	28	1	0	0	0	0	1	0	0	0	4646	912	32	1	60	1	DNAJC28	21	34860591	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	4158729	34860591	13269304	340	7970										
PDE9A	5152	broad.mit.edu	37	chr21	44179187	44179187	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcaaccctgtcaccctcaggAggtggctggtgagtgccaaa	12	12	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr21:44179187A>T	uc002zbm.2	+	11	952	c.889A>T	c.(889-891)AGG>TGG	p.R297W	PDE9A_uc002zbn.2_Missense_Mutation_p.R170W|PDE9A_uc002zbo.2_Missense_Mutation_p.R244W|PDE9A_uc002zbp.2_Missense_Mutation_p.R90W|PDE9A_uc002zbq.2_Missense_Mutation_p.R195W|PDE9A_uc002zbs.2_Missense_Mutation_p.R90W|PDE9A_uc002zbr.2_Missense_Mutation_p.R90W|PDE9A_uc002zbt.2_Missense_Mutation_p.R169W|PDE9A_uc002zbu.2_Missense_Mutation_p.R163W|PDE9A_uc002zbv.2_Missense_Mutation_p.R137W|PDE9A_uc002zbw.2_Missense_Mutation_p.R80W|PDE9A_uc002zbx.2_Missense_Mutation_p.R237W|PDE9A_uc002zby.2_Missense_Mutation_p.R80W|PDE9A_uc002zbz.2_Missense_Mutation_p.R189W|PDE9A_uc002zca.2_Missense_Mutation_p.R256W|PDE9A_uc002zcb.2_Missense_Mutation_p.R271W|PDE9A_uc002zcc.2_Missense_Mutation_p.R196W|PDE9A_uc002zcd.2_Missense_Mutation_p.R211W|PDE9A_uc002zce.2_Missense_Mutation_p.R230W|PDE9A_uc002zcf.2_Missense_Mutation_p.R90W|PDE9A_uc002zcg.2_Missense_Mutation_p.R90W|PDE9A_uc002zch.2_Missense_Mutation_p.R80W|PDE9A_uc010gpf.1_Missense_Mutation_p.R90W	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	297	Catalytic (By similarity).				platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						CACCCTCAGGAGGTGGCTGGT	0.587													0	0	0	0.009096	0	3	30										T	44179187	A	T	44179187	3	4	28	1	0	0	0	0	1	0	0	0	11655	295	11	5	1011	5	PDE9A	21	44179187	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	9318596	44179187	3950708	341	7971										
GAB4	128954	broad.mit.edu	37	chr22	17449260	17449260	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	cctccaccatgctgggtgtaCttgccggaggaagctacgac	12	13	0	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr22:17449260C>T	uc002zlw.2	-	5	1059	c.951G>A	c.(949-951)AAG>AAA	p.K317K	GAB4_uc010gqs.1_Missense_Mutation_p.V217I	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	317										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGGGTGTACTTGCCGGAGG	0.577													0	0	0	0.00245	0	11	45										T	17449260	C	T	17449260	2	4	28	1	0	0	0	0	0	0	0	1	6151	564	20	2		2	GAB4	22	17449260	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08		17449260	33855306	342	7972										
ATP6V1E1	529	broad.mit.edu	37	chr22	18075495	18075495	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	acaaggctccccggacttctGgcatcatctgtggagagaaa	11	11	3	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr22:18075495G>C	uc002zmr.1	-	9	813	c.626C>G	c.(625-627)CCA>CGA	p.P209R	ATP6V1E1_uc002zms.1_Missense_Mutation_p.P179R|ATP6V1E1_uc002zmt.1_Missense_Mutation_p.P187R	NM_001696	NP_001687	P36543	VATE1_HUMAN	vacuolar H+ ATPase E1 isoform a	209					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|cytosol|endosome|proton-transporting two-sector ATPase complex, catalytic domain	protein binding|proton-transporting ATPase activity, rotational mechanism			large_intestine(1)|central_nervous_system(1)	2		all_epithelial(15;0.206)		Lung(27;0.19)		CCGGACTTCTGGCATCATCTG	0.423													0	0	0	0.005443	0	25	84										C	18075495	G	C	18075495	3	2	28	1	0	0	0	0	1	0	0	0	1183	1348	47	4	58	4	ATP6V1E1	22	18075495	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	626235	18075495	33229071	343	7973										
SEC14L3	266629	broad.mit.edu	37	chr22	30866040	30866040	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	aatcaaggatatggtcaataTccatggtcttccggaactcc	8	10	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr22:30866040T>A	uc003ahy.2	-	4	289	c.200A>T	c.(199-201)GAT>GTT	p.D67V	SEC14L3_uc003ahz.2_5'UTR|SEC14L3_uc003aia.2_Missense_Mutation_p.D8V|SEC14L3_uc003aib.2_Missense_Mutation_p.D8V	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	67						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	ATGGTCAATATCCATGGTCTT	0.542													0	0	0	0.00361	0	109	59										A	30866040	T	A	30866040	3	1	28	1	0	0	0	0	1	0	0	0	13983	1435	50	5	1038	5	SEC14L3	22	30866040	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	12790545	30866040	20438526	344	7974										
APOL1	8542	broad.mit.edu	37	chr22	36661303	36661303	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agcagtacagaaactggtttCtgaaagagtttcctcggttg	11	7	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr22:36661303C>T	uc003apf.2	+	6	589	c.421C>T	c.(421-423)CTG>TTG	p.L141L	APOL1_uc011amn.1_Silent_p.L18L|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Silent_p.L157L|APOL1_uc011amo.1_Silent_p.L18L|APOL1_uc011amp.1_Silent_p.L141L|APOL1_uc011amq.1_Silent_p.L123L|APOL1_uc010gwx.2_Silent_p.L18L	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	141					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						AAACTGGTTTCTGAAAGAGTT	0.473													0	0	0	0.004007	0	16	82										T	36661303	C	T	36661303	2	4	28	1	0	0	0	0	0	0	0	1	805	912	32	1		1	APOL1	22	36661303	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	5795263	36661303	14643263	345	7975										
CACNA1I	8911	broad.mit.edu	37	chr22	40066081	40066081	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccctggatgctgctgtacttCatctccttcctgctcatcgt	7	15	3	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr22:40066081C>T	uc003ayc.2	+	25	4233	c.4233C>T	c.(4231-4233)TTC>TTT	p.F1411F	CACNA1I_uc003ayd.2_Silent_p.F1376F|CACNA1I_uc003aye.2_Silent_p.F1326F|CACNA1I_uc003ayf.2_Silent_p.F1291F	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1411	Helical; Name=S6 of repeat III; (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	TGCTGTACTTCATCTCCTTCC	0.577													0	0	0	0.006999	0	37	194										T	40066081	C	T	40066081	2	4	28	1	0	0	0	0	0	0	0	1	2546	825	29	1		1	CACNA1I	22	40066081	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	3404778	40066081	11238485	346	7976										
SAPS2	9701	broad.mit.edu	37	chr22	50869673	50869673	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctatgcatagccgctattctCtcccacgctgcccgtgagga	9	15	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chr22:50869673C>G	uc003blb.1	+	12	1619	c.1197C>G	c.(1195-1197)CTC>CTG	p.L399L	SAPS2_uc003bky.1_Silent_p.L399L|SAPS2_uc003bkz.1_Silent_p.L399L|SAPS2_uc003blc.2_Silent_p.L399L|SAPS2_uc003bla.1_Silent_p.L400L|SAPS2_uc003bld.1_5'UTR	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	399						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		CCGCTATTCTCTCCCACGCTG	0.547													0	0	0	0.004878	0	31	100										G	50869673	C	G	50869673	2	3	28	1	0	0	0	0	0	0	0	1	13837	900	32	1		1	SAPS2	22	50869673	Silent	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	10803592	50869673	434893	347	7977										
TLR8	51311	broad.mit.edu	37	chrX	12939592	12939592	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agtcctggggatcaaagaggGaagagtattgtgagtctgga	16	4	2	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:12939592G>A	uc004cve.2	+	2	2501	c.2433G>A	c.(2431-2433)GGG>GGA	p.G811G	TLR8_uc004cvd.2_Silent_p.G829G	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	811	Extracellular (Potential).|LRRCT.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						ATCAAAGAGGGAAGAGTATTG	0.418													0	0	0	0.002096	0	30	186										A	12939592	G	A	12939592	2	1	28	1	0	0	0	0	0	0	0	1	15954	1161	41	1		1	TLR8	23	12939592	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08		12939592	142330968	348	7978										
BMX	660	broad.mit.edu	37	chrX	15534291	15534291	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	atagtgggttcttcgtggacGggaagttcctgtgttgccag	15	7	1	0	rs67912403		TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:15534291G>T	uc004cww.2	+	5	570	c.382G>T	c.(382-384)GGG>TGG	p.G128W	BMX_uc004cwx.3_Missense_Mutation_p.G128W|BMX_uc004cwy.3_Missense_Mutation_p.G128W	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	128	Btk-type.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					CTTCGTGGACGGGAAGTTCCT	0.517													1	0	4.3838e-07	0.001855	4.65083e-07	12	306										T	15534291	G	T	15534291	3	4	28	1	0	0	0	0	1	0	0	0	1473	1116	39	4	396	4	BMX	23	15534291	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2594699	15534291	139736269	349	7979										
FAM48B1	100130302	broad.mit.edu	37	chrX	24383471	24383471	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcagatagtgcagccacatcCaggtgtgcaagtagggagcc	13	10	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:24383471C>G	uc011mjx.1	+	1	2594	c.2594C>G	c.(2593-2595)CCA>CGA	p.P865R		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						CAGCCACATCCAGGTGTGCAA	0.542													0	0	0	0.003163	0	14	84										G	24383471	C	G	24383471	3	3	28	1	0	0	0	0	1	0	0	0	5573	594	21	4	2596	4	FAM48B1	23	24383471	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	8849180	24383471	130887089	350	7980										
TSPAN7	7102	broad.mit.edu	37	chrX	38534989	38534989	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtggtgtgcagaactacaccAactggagcaccagcccctac	10	14	0	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:38534989A>T	uc004deg.3	+	5	541	c.472A>T	c.(472-474)AAC>TAC	p.N158Y	TSPAN7_uc011mkj.1_Missense_Mutation_p.N184Y|TSPAN7_uc011mkk.1_Missense_Mutation_p.N175Y|TSPAN7_uc004deh.2_Missense_Mutation_p.N66Y	NM_004615	NP_004606	P41732	TSN7_HUMAN	tetraspanin 7	158	Extracellular (Potential).				interspecies interaction between organisms	integral to plasma membrane				ovary(1)	1						GAACTACACCAACTGGAGCAC	0.483													0	0	0	0.002299	0	23	50										T	38534989	A	T	38534989	3	4	28	1	0	0	0	0	1	0	0	0	16649	130	5	5	490	5	TSPAN7	23	38534989	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	14151518	38534989	116735571	351	7981										
CXorf38	159013	broad.mit.edu	37	chrX	40496396	40496396	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	agagtgcatgatctcattacGacatttaattacctgcagaa	7	8	1	3			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:40496396G>A	uc004dew.2	-	4	489	c.484C>T	c.(484-486)CGT>TGT	p.R162C	CXorf38_uc011mko.1_Missense_Mutation_p.R77C|CXorf38_uc004dev.1_Missense_Mutation_p.R43C|CXorf38_uc010nhd.2_RNA	NM_144970	NP_659407	Q8TB03	CX038_HUMAN	hypothetical protein LOC159013	162										ovary(1)	1						ATCTCATTACGACATTTAATT	0.338													0	0	0	0.001168	0	5	91										A	40496396	G	A	40496396	3	1	28	1	0	0	0	0	1	0	0	0	4107	1058	37	1	487	1	CXorf38	23	40496396	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1961407	40496396	114774164	352	7982										
KDM6A	7403	broad.mit.edu	37	chrX	44941860	44941861	+	Frame_Shift_Ins	INS	-	-	A													0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcatcataaagaccactcagINSatagtgaatctacatcgtca							TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:44941860_44941861insA	uc004dge.3	+	21	3559_3560	c.3184_3185insA	c.(3184-3186)GATfs	p.D1062fs	KDM6A_uc011mkz.1_Frame_Shift_Ins_p.D1114fs|KDM6A_uc011mla.1_Frame_Shift_Ins_p.D1017fs|KDM6A_uc011mlb.1_Frame_Shift_Ins_p.D1069fs|KDM6A_uc011mlc.1_Frame_Shift_Ins_p.D766fs|KDM6A_uc011mld.1_Frame_Shift_Ins_p.D701fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1062					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AGACCACTCAGATAGTGAATCT	0.317			D|N|F|S		renal|oesophageal SCC|MM													44	95	---	---								A	44941861	-	A	44941860	7	5	28	1	0	1	1	0	0	0	0	0	8137	942	33	0	3266	0	KDM6A	23	44941860	Frame_Shift_Ins	INS	-	TCGA-CF-A1HS-01A-11D-A13W-08	4445464	44941860	110328700	353	7983										
HDAC6	10013	broad.mit.edu	37	chrX	48666514	48666514	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccacgtggctgtggcagcccGctatgctcaacagaaacacc	10	15	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:48666514G>T	uc011mmi.1	+	9	802	c.707G>T	c.(706-708)CGC>CTC	p.R236L	HDAC6_uc004dks.1_Missense_Mutation_p.R236L|HDAC6_uc010nig.1_Missense_Mutation_p.R84L|HDAC6_uc004dkt.1_Missense_Mutation_p.R236L|HDAC6_uc011mmj.1_Missense_Mutation_p.R181L|HDAC6_uc011mmk.1_Missense_Mutation_p.R217L	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	236	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	GTGGCAGCCCGCTATGCTCAA	0.582													1	0	0.000274275	0.004482	0.000283079	5	10										T	48666514	G	T	48666514	3	4	28	1	0	0	0	0	1	0	0	0	7011	1087	38	4	737	4	HDAC6	23	48666514	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	3724654	48666514	106604046	354	7984										
PAGE1	8712	broad.mit.edu	37	chrX	49454135	49454135	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctgttcctggctatccgcttCaggctctggcccttaaaaaa	8	13	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:49454135C>T	uc004dom.2	-	5	437	c.304G>A	c.(304-306)GAA>AAA	p.E102K		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	102					cellular defense response					skin(1)	1	Ovarian(276;0.236)					CTATCCGCTTCAGGCTCTGGC	0.338													0	0	0	0.003755	0	29	72										T	49454135	C	T	49454135	3	4	28	1	0	0	0	0	1	0	0	0	11389	835	29	1	144	1	PAGE1	23	49454135	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	787621	49454135	105816425	355	7985										
TRO	7216	broad.mit.edu	37	chrX	54949137	54949137	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	caaccaaggactccctggccAtggacccaccagttgtcaac	8	16	1	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:54949137A>G	uc004dtq.2	+	3	279	c.172A>G	c.(172-174)ATG>GTG	p.M58V	TRO_uc011moj.1_Missense_Mutation_p.M1V|TRO_uc004dts.2_Missense_Mutation_p.M58V|TRO_uc004dtr.2_Missense_Mutation_p.M58V|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	58					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CTCCCTGGCCATGGACCCACC	0.557													0	0	0	0.00499	0	17	22										G	54949137	A	G	54949137	3	3	28	1	0	0	0	0	1	0	0	0	16571	217	8	5	178	5	TRO	23	54949137	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	5495002	54949137	100321423	356	7986										
TAF1	6872	broad.mit.edu	37	chrX	70601652	70601652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ccatttttcccattgacaatGaggatctggtatatggacgc	9	9	1	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:70601652G>C	uc004dzu.3	+	9	1468	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.E494Q	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	473					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				CATTGACAATGAGGATCTGGT	0.453													0	0	0	0.001168	0	5	216										C	70601652	G	C	70601652	3	2	28	1	0	0	0	0	1	0	0	0	15510	1291	45	1	1514	1	TAF1	23	70601652	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	15652515	70601652	84668908	357	7987										
PAK3	5063	broad.mit.edu	37	chrX	110435399	110435399	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	actagacattgcaacaggacAagaggtaagtgctaacgttc	10	8	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:110435399A>G	uc004epa.2	+	9	947	c.920A>G	c.(919-921)CAA>CGA	p.Q307R	PAK3_uc010npt.1_Missense_Mutation_p.Q292R|PAK3_uc010npu.1_Missense_Mutation_p.Q292R|PAK3_uc004eoy.1_Missense_Mutation_p.Q47R|PAK3_uc004eoz.2_Missense_Mutation_p.Q292R|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.Q328R|PAK3_uc010npw.1_Missense_Mutation_p.Q313R	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	307	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GCAACAGGACAAGAGGTAAGT	0.333										TSP Lung(19;0.15)			0	0	0	0.001984	0	7	173										G	110435399	A	G	110435399	3	3	28	1	0	0	0	0	1	0	0	0	11402	130	5	5	1021	5	PAK3	23	110435399	Missense_Mutation	SNP	A	TCGA-CF-A1HS-01A-11D-A13W-08	39833747	110435399	44835161	358	7988										
MCTS1	28985	broad.mit.edu	37	chrX	119742109	119742109	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tcctgccacaccagcaggttGataaaggagccatcaaattt	8	11	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:119742109G>C	uc004esx.2	+	4	640	c.292G>C	c.(292-294)GAT>CAT	p.D98H	MCTS1_uc011mub.1_Missense_Mutation_p.D99H	NM_014060	NP_054779	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1 isoform 1	98	PUA.				cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding				0						CCAGCAGGTTGATAAAGGAGC	0.308													0	0	0	0.001368	0	12	101										C	119742109	G	C	119742109	3	2	28	1	0	0	0	0	1	0	0	0	9402	1290	45	1	324	1	MCTS1	23	119742109	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	9306710	119742109	35528451	359	7989										
FAM127B	26071	broad.mit.edu	37	chrX	134185976	134185976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtcgttggagaacgtgttctCgtccacgaacatgtaggagc	13	9	1	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:134185976C>T	uc004eyf.2	-	1	246	c.163G>A	c.(163-165)GAG>AAG	p.E55K	FAM127B_uc004eyg.3_Missense_Mutation_p.E55K	NM_001078172	NP_001071640	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	55											0	Acute lymphoblastic leukemia(192;0.000127)					AACGTGTTCTCGTCCACGAAC	0.597													0	0	0	0.001168	0	6	90										T	134185976	C	T	134185976	3	4	28	1	0	0	0	0	1	0	0	0	5432	893	31	1	246	1	FAM127B	23	134185976	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	14443867	134185976	21084584	360	7990										
GPR112	139378	broad.mit.edu	37	chrX	135429691	135429691	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	ctagaactatggaggtgacaGaaatgtccccatcaaagaat	9	8	1	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:135429691G>C	uc004ezu.1	+	6	4117	c.3826G>C	c.(3826-3828)GAA>CAA	p.E1276Q	GPR112_uc010nsb.1_Missense_Mutation_p.E1071Q|GPR112_uc010nsc.1_Missense_Mutation_p.E1043Q	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1276	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GGAGGTGACAGAAATGTCCCC	0.438													0	0	0	0.00361	0	59	117										C	135429691	G	C	135429691	3	2	28	1	0	0	0	0	1	0	0	0	6629	943	33	1	3836	1	GPR112	23	135429691	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1243715	135429691	19840869	361	7991										
GPR101	83550	broad.mit.edu	37	chrX	136112838	136112838	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gtgcgacccttgtctgccttCatgctgttctcctcaacttt	7	14	4	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:136112838C>A	uc011mwh.1	-	1	996	c.996G>T	c.(994-996)ATG>ATT	p.M332I		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TGTCTGCCTTCATGCTGTTCT	0.557													1	0	4.44401e-20	0.002522	4.94042e-20	46	304										A	136112838	C	A	136112838	3	1	28	1	0	0	0	0	1	0	0	0	6622	826	29	3	533	3	GPR101	23	136112838	Missense_Mutation	SNP	C	TCGA-CF-A1HS-01A-11D-A13W-08	683147	136112838	19157722	362	7992										
F9	2158	broad.mit.edu	37	chrX	138612920	138612920	+	Translation_Start_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tttcacaatctgctagcaaaGgttatgcagcgcgtgaacat	9	9	2	1			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:138612920G>T	uc004fas.1	+	1	26	c.-3G>T	c.(-5--1)AAGGT>AATGT		F9_uc004fat.1_Translation_Start_Site	NM_000133	NP_000124	P00740	FA9_HUMAN	coagulation factor IX preproprotein						blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			lung(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	TGCTAGCAAAGGTTATGCAGC	0.433													1	0	2.0095e-06	0.001984	2.12114e-06	6	128										T	138612920	G	T	138612920	1	4	28	1	0	0	0	0	0	0	0	0	5351	1015	35	4		4	F9	23	138612920	Translation_Start_Site	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	2500082	138612920	16657640	363	7993										
MAGEA6	4105	broad.mit.edu	37	chrX	151870004	151870004	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tgagtgtgttagaggtgtttGaggggagggaagacagtatc	18	2	0	4			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:151870004G>C	uc004ffq.1	+	3	888	c.694G>C	c.(694-696)GAG>CAG	p.E232Q	MAGEA6_uc004ffr.1_Missense_Mutation_p.E232Q|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	232	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGGTGTTTGAGGGGAGGGA	0.537													0	0	0	0.00361	0	76	203										C	151870004	G	C	151870004	3	2	28	1	0	0	0	0	1	0	0	0	9170	1291	45	1	696	1	MAGEA6	23	151870004	Missense_Mutation	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	13257084	151870004	3400556	364	7994										
L1CAM	3897	broad.mit.edu	37	chrX	153128148	153128148	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	gccacggcagggttgatgggGgaagtggcccctgagctgtc	18	10	0	2			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:153128148G>A	uc004fjb.2	-	28	3852	c.3744C>T	c.(3742-3744)TCC>TCT	p.S1248S	L1CAM_uc004fjc.2_Silent_p.S1244S|L1CAM_uc010nuo.2_Silent_p.S1239S	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1248	Cytoplasmic (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTTGATGGGGGAAGTGGCCC	0.607													0	0	0	0.009096	0	4	59										A	153128148	G	A	153128148	2	1	28	1	0	0	0	0	0	0	0	1	8588	1219	43	2		2	L1CAM	23	153128148	Silent	SNP	G	TCGA-CF-A1HS-01A-11D-A13W-08	1258144	153128148	2142412	365	7995										
MTCP1NB	100272147	broad.mit.edu	37	chrX	154292253	154292253	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.418032786885246	153	4.20455368330359e-51	3.61784633452279	4.39002312002821	2.56740764433072	4.17308071090612e-11	7.75000703453994e-10	111	tatactaccttgtaaacattTctgtatctcacaggcttgct	5	10	2	0			TCGA-CF-A1HS-01A-11D-A13W-08	TCGA-CF-A1HS-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b36e672b-c5d8-4481-bbb3-7be805215212	d99033c8-519c-4dca-b4c4-0d77b418a7ff	g.chrX:154292253T>G	uc004fmy.2	-	2	635	c.46A>C	c.(46-48)AAA>CAA	p.K16Q		NM_001018024	NP_001018024	P56277	MTCNB_HUMAN	mature T-cell proliferation 1 neighbor	16					cell proliferation	mitochondrion				lung(1)	1						TGTAAACATTTCTGTATCTCA	0.299													0	0	0	0.010504	0	21	285										G	154292253	T	G	154292253	3	3	28	1	0	0	0	0	1	0	0	0	9916	1792	62	5	168	5	MTCP1NB	23	154292253	Missense_Mutation	SNP	T	TCGA-CF-A1HS-01A-11D-A13W-08	1164105	154292253	978307	366	7996										
CCDC27	148870	broad.mit.edu	37	chr1	3669321	3669321	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	caccaaaagccacgcacgctCagcaagtcggtccagaccat	8	16	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:3669321C>G	uc001akv.2	+	1	357	c.276C>G	c.(274-276)CTC>CTG	p.L92L		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	92										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CACGCACGCTCAGCAAGTCGG	0.637													0	0	0	0.002836	0	31	23										G	3669321	C	G	3669321	2	3	29	1	0	0	0	0	0	0	0	1	2801	813	29	1		1	CCDC27	1	3669321	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		3669321	245581300	1	7997										
KIAA0090	23065	broad.mit.edu	37	chr1	19549914	19549914	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acccagttctctgaatgcacGatatggacagggcctttggc	11	11	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:19549914G>A	uc001bbo.2	-	19	2395	c.2352C>T	c.(2350-2352)ATC>ATT	p.I784I	KIAA0090_uc001bbn.2_5'Flank|KIAA0090_uc001bbp.2_Silent_p.I783I|KIAA0090_uc001bbq.2_Silent_p.I783I|KIAA0090_uc001bbr.2_Silent_p.I762I	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	784	DUF1620.|Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		CTGAATGCACGATATGGACAG	0.537													0	0	0	0.00361	0	86	163										A	19549914	G	A	19549914	2	1	29	1	0	0	0	0	0	0	0	1	8153	1048	37	1		1	KIAA0090	1	19549914	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	15880593	19549914	229700707	2	7998										
PTP4A2	8073	broad.mit.edu	37	chr1	32384631	32384631	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gttatcagaaaacgcatgttCtcataggagatctccacagg	9	9	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:32384631C>G	uc001bty.1	-	2	1030	c.36G>C	c.(34-36)GAG>GAC	p.E12D	PTP4A2_uc010ogs.1_Missense_Mutation_p.E12D|PTP4A2_uc001btz.1_Missense_Mutation_p.E12D	NM_080391	NP_536316	Q12974	TP4A2_HUMAN	protein tyrosine phosphatase type IVA, member 2	12						early endosome|plasma membrane	prenylated protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity				0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)				AACGCATGTTCTCATAGGAGA	0.413													0	0	0	0.003271	0	34	42										G	32384631	C	G	32384631	3	3	29	1	0	0	0	0	1	0	0	0	12771	912	32	1	487	1	PTP4A2	1	32384631	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	12834717	32384631	216865990	3	7999										
MACF1	23499	broad.mit.edu	37	chr1	39550081	39550081	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccaggattcggtgctggaccCtgcagagcgtgctgtggtca	15	11	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:39550081C>T	uc010ois.1	+	3	396	c.191C>T	c.(190-192)CCT>CTT	p.P64L	MACF1_uc010oir.1_Silent_p.L60L	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	64	Actin-binding.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTGCTGGACCCTGCAGAGCGT	0.632													0	0	0	0.008871	0	19	20										T	39550081	C	T	39550081	3	4	29	1	0	0	0	0	1	0	0	0	9144	681	24	2	193	2	MACF1	1	39550081	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	7165450	39550081	209700540	4	8000										
SSBP3	23648	broad.mit.edu	37	chr1	54867580	54867580	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttgaatgttcacaagtgtctCtcctttcaggagctgcacag	9	10	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:54867580C>G	uc001cxe.2	-	4	528	c.230G>C	c.(229-231)AGA>ACA	p.R77T	SSBP3_uc001cxf.2_Missense_Mutation_p.R77T|SSBP3_uc001cxg.2_Missense_Mutation_p.R77T	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						ACAAGTGTCTCTCCTTTCAGG	0.368													0	0	0	0.00361	0	42	57										G	54867580	C	G	54867580	3	3	29	1	0	0	0	0	1	0	0	0	15180	913	32	1	996	1	SSBP3	1	54867580	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	15317499	54867580	194383041	5	8001										
ABCD3	5825	broad.mit.edu	37	chr1	94964399	94964399	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gaggaaaattattttatgttCctcaggtaagacctagcttg	9	6	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:94964399C>G	uc001dqn.3	+	18	1627	c.1525C>G	c.(1525-1527)CCT>GCT	p.P509A	ABCD3_uc010oto.1_Missense_Mutation_p.P533A|ABCD3_uc010otp.1_Missense_Mutation_p.P436A|ABCD3_uc009wdr.2_Missense_Mutation_p.P399A|ABCD3_uc001dqo.3_Missense_Mutation_p.P197A	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	509	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		ATTTTATGTTCCTCAGGTAAG	0.318													0	0	0	0.00623	0	38	42										G	94964399	C	G	94964399	3	3	29	1	0	0	0	0	1	0	0	0	62	855	30	1	1626	1	ABCD3	1	94964399	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	40096819	94964399	154286222	6	8002										
AGL	178	broad.mit.edu	37	chr1	100366410	100366410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttctgctcctttgcctgctgGcacactggtaaagatatttc	8	11	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:100366410G>A	uc001dsi.1	+	26	3981	c.3581G>A	c.(3580-3582)GGC>GAC	p.G1194D	AGL_uc001dsj.1_Missense_Mutation_p.G1194D|AGL_uc001dsk.1_Missense_Mutation_p.G1194D|AGL_uc001dsl.1_Missense_Mutation_p.G1194D|AGL_uc001dsm.1_Missense_Mutation_p.G1178D|AGL_uc001dsn.1_Missense_Mutation_p.G1177D	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1194	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTGCCTGCTGGCACACTGGTA	0.318													0	0	0	0.000248	0	4	144										A	100366410	G	A	100366410	3	1	29	1	0	0	0	0	1	0	0	0	384	1203	42	2	3748	2	AGL	1	100366410	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	5402011	100366410	148884211	7	8003										
ANP32E	81611	broad.mit.edu	37	chr1	150198965	150198965	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tttcttctttcattaagtatGagaggcccacttcctcttct	5	11	5	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:150198965G>A	uc001etw.2	-	5	1026	c.656C>T	c.(655-657)TCA>TTA	p.S219L	ANP32E_uc010pbt.1_RNA|ANP32E_uc010pbu.1_Missense_Mutation_p.S171L|ANP32E_uc010pbv.1_Missense_Mutation_p.S178L|ANP32E_uc001etv.3_Missense_Mutation_p.S219L|ANP32E_uc010pbw.1_Missense_Mutation_p.H164Y	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	219	Asp/Glu-rich (highly acidic).					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CATTAAGTATGAGAGGCCCAC	0.274													0	0	0	0.00361	0	43	52										A	150198965	G	A	150198965	3	1	29	1	0	0	0	0	1	0	0	0	709	1294	45	1	162	1	ANP32E	1	150198965	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	49832555	150198965	99051656	8	8004										
CRTC2	200186	broad.mit.edu	37	chr1	153921728	153921728	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggactgcactgaacaagactGagagggcagccctggctgct	14	11	0	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:153921728G>C	uc010ped.1	-	12	1607	c.1537C>G	c.(1537-1539)CAG>GAG	p.Q513E	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Missense_Mutation_p.Q49E	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	513					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAACAAGACTGAGAGGGCAGC	0.617													0	0	0	0.002522	0	45	45										C	153921728	G	C	153921728	3	2	29	1	0	0	0	0	1	0	0	0	3900	1299	45	1	556	1	CRTC2	1	153921728	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3722763	153921728	95328893	9	8005										
YY1AP1	55249	broad.mit.edu	37	chr1	155629952	155629952	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atgggaatagtctggggactCtgggccacagccgcattgac	14	10	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:155629952C>G	uc001fln.2	-	11	1911	c.1887G>C	c.(1885-1887)CAG>CAC	p.Q629H	YY1AP1_uc001flg.2_Missense_Mutation_p.Q368H|YY1AP1_uc010pgg.1_Missense_Mutation_p.Q468H|YY1AP1_uc010pgh.1_Missense_Mutation_p.Q572H|YY1AP1_uc010pgi.1_Missense_Mutation_p.Q721H|YY1AP1_uc001flh.2_Missense_Mutation_p.Q701H|YY1AP1_uc009wqt.2_Missense_Mutation_p.Q552H|YY1AP1_uc001flk.2_Missense_Mutation_p.Q572H|YY1AP1_uc001fll.2_Missense_Mutation_p.Q583H|YY1AP1_uc009wqv.2_Missense_Mutation_p.Q300H|YY1AP1_uc001flm.2_Missense_Mutation_p.Q572H|YY1AP1_uc001fli.2_Missense_Mutation_p.Q583H|YY1AP1_uc009wqu.2_Missense_Mutation_p.Q416H|YY1AP1_uc001flj.2_Missense_Mutation_p.Q563H|YY1AP1_uc009wqw.2_Missense_Mutation_p.Q552H|YY1AP1_uc001flo.2_Missense_Mutation_p.Q517H|YY1AP1_uc001flp.2_Missense_Mutation_p.Q583H	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	629					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TCTGGGGACTCTGGGCCACAG	0.542													0	0	0	0.00361	0	48	44										G	155629952	C	G	155629952	3	3	29	1	0	0	0	0	1	0	0	0	17505	912	32	1	507	1	YY1AP1	1	155629952	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	1708224	155629952	93620669	10	8006										
HMCN1	83872	broad.mit.edu	37	chr1	186034488	186034488	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	accaatgtccaggtgccacaCactggaagatatacatgttt	8	10	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:186034488C>T	uc001grq.1	+	49	7861	c.7632C>T	c.(7630-7632)CAC>CAT	p.H2544H		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2544	Ig-like C2-type 23.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGGTGCCACACACTGGAAGAT	0.458													0	0	0	0.000248	0	4	34										T	186034488	C	T	186034488	2	4	29	1	0	0	0	0	0	0	0	1	7220	477	17	2		2	HMCN1	1	186034488	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	30404536	186034488	63216133	11	8007										
HMCN1	83872	broad.mit.edu	37	chr1	186062644	186062644	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctacaattaggggtaataaaGatgaagcagagaaactaatg	10	4	0	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:186062644G>C	uc001grq.1	+	66	10268	c.10039G>C	c.(10039-10041)GAT>CAT	p.D3347H		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3347	Ig-like C2-type 32.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GGGTAATAAAGATGAAGCAGA	0.383													0	0	0	0.00361	0	62	62										C	186062644	G	C	186062644	3	2	29	1	0	0	0	0	1	0	0	0	7220	942	33	1	10301	1	HMCN1	1	186062644	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	28156	186062644	63187977	12	8008										
CR2	1380	broad.mit.edu	37	chr1	207647168	207647168	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acatgccagcatgtgagacaGagtcttcaagaacttccagc	9	11	2	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:207647168G>C	uc001hfw.2	+	11	2095	c.2001G>C	c.(1999-2001)CAG>CAC	p.Q667H	CR2_uc001hfv.2_Missense_Mutation_p.Q726H|CR2_uc009xch.2_Missense_Mutation_p.Q667H	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	667	Sushi 11.|Extracellular (Potential).			Q -> D (in Ref. 10; AA sequence).	complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						ATGTGAGACAGAGTCTTCAAG	0.418													0	0	0	0.00361	0	66	71										C	207647168	G	C	207647168	3	2	29	1	0	0	0	0	1	0	0	0	3842	933	33	1	2224	1	CR2	1	207647168	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	21584524	207647168	41603453	13	8009										
CD34	947	broad.mit.edu	37	chr1	208061201	208061201	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggcctttccctgagcctcaGgggaggtcccaggtcctgag	14	13	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:208061201G>A	uc001hgw.1	-	8	1298	c.1040C>T	c.(1039-1041)CCT>CTT	p.P347L	CD34_uc001hgv.1_Missense_Mutation_p.P189L|CD34_uc001hgx.1_3'UTR|CD34_uc010psj.1_Missense_Mutation_p.P212L	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	347	Cytoplasmic (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						CTGAGCCTCAGGGGAGGTCCC	0.557													0	0	0	0.001786	0	32	26										A	208061201	G	A	208061201	3	1	29	1	0	0	0	0	1	0	0	0	3006	1000	35	2	121	2	CD34	1	208061201	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	414033	208061201	41189420	14	8010										
CENPF	1063	broad.mit.edu	37	chr1	214826232	214826232	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	taaagaagaatgtctcagttCacagaagctggagatagacc	10	7	2	5			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:214826232C>T	uc001hkm.2	+	16	8396	c.8222C>T	c.(8221-8223)TCA>TTA	p.S2741L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2837	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGTCTCAGTTCACAGAAGCTG	0.328													0	0	0	0.00623	0	40	39										T	214826232	C	T	214826232	3	4	29	1	0	0	0	0	1	0	0	0	3231	838	29	1	8280	1	CENPF	1	214826232	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	6765031	214826232	34424389	15	8011										
C1orf58	148362	broad.mit.edu	37	chr1	222902115	222902115	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atccagtttggagcctgcatAttctgccaaatggagaaaat	9	8	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:222902115A>G	uc001hnq.1	+	9	1096	c.701A>G	c.(700-702)TAT>TGT	p.Y234C	C1orf58_uc010put.1_Missense_Mutation_p.Y202C|C1orf58_uc010puu.1_Missense_Mutation_p.Y234C|C1orf58_uc010puv.1_Missense_Mutation_p.Y202C|uc001hnr.1_RNA	NM_144695	NP_653296	Q5VW32	BROX_HUMAN	Bro1-domain-containing protein	234	BRO1.					membrane					0				GBM - Glioblastoma multiforme(131;0.0667)		GAGCCTGCATATTCTGCCAAA	0.318													0	0	0	0.00278	0	22	25										G	222902115	A	G	222902115	3	3	29	1	0	0	0	0	1	0	0	0	2050	449	16	5	731	5	C1orf58	1	222902115	Missense_Mutation	SNP	A	TCGA-CF-A27C-01A-11D-A16O-08	8075883	222902115	26348506	16	8012										
MTR	4548	broad.mit.edu	37	chr1	237060354	237060354	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggcacctgcttcagcagtctCaggcctctacttctccaatt	7	15	4	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:237060354C>G	uc001hyi.3	+	32	4070	c.3647C>G	c.(3646-3648)TCA>TGA	p.S1216*	MTR_uc010pxw.1_Nonsense_Mutation_p.S809*|MTR_uc010pxx.1_Nonsense_Mutation_p.S1165*|MTR_uc010pxy.1_Nonsense_Mutation_p.S1070*	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	1216	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TCAGCAGTCTCAGGCCTCTAC	0.403													0	0	0	0.00361	0	103	115										G	237060354	C	G	237060354	4	3	29	1	0	0	0	0	0	1	0	0	9958	838	29	1	3773	1	MTR	1	237060354	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	14158239	237060354	12190267	17	8013										
RYR2	6262	broad.mit.edu	37	chr1	237949319	237949319	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gaaaaagaagaaaccaaatcTgaacctgaaaaagccgagta	8	7	1	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:237949319T>A	uc001hyl.1	+	91	13431	c.13311T>A	c.(13309-13311)TCT>TCA	p.S4437S	RYR2_uc010pya.1_Silent_p.S852S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4437	Potential.|Glu-rich (acidic).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			aaACCAAATCTGAACCTGAAA	0.338													0	0	0	0.006214	0	10	5										A	237949319	T	A	237949319	2	1	29	1	0	0	0	0	0	0	0	1	13769	1567	55	5		5	RYR2	1	237949319	Silent	SNP	T	TCGA-CF-A27C-01A-11D-A16O-08	888965	237949319	11301302	18	8014										
HNRNPU	3192	broad.mit.edu	37	chr1	245018742	245018742	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttacctggttgtagttccctCtgttgggcattccacctctg	9	12	2	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:245018742C>G	uc001iaz.1	-	12	2554	c.2336G>C	c.(2335-2337)AGA>ACA	p.R779T	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.R503T|HNRNPU_uc001iba.1_Missense_Mutation_p.R760T	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	779	Gly-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			GTAGTTCCCTCTGTTGGGCAT	0.478													0	0	0	0.00361	0	99	163										G	245018742	C	G	245018742	3	3	29	1	0	0	0	0	1	0	0	0	7273	913	32	1	153	1	HNRNPU	1	245018742	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	7069423	245018742	4231879	19	8015										
NLRP3	114548	broad.mit.edu	37	chr1	247607346	247607346	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctcagcactaatcagaatctCacgcacctttacctgcgagg	7	14	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:247607346C>G	uc001icr.2	+	9	2880	c.2742C>G	c.(2740-2742)CTC>CTG	p.L914L	NLRP3_uc001ics.2_Silent_p.L857L|NLRP3_uc001icu.2_Silent_p.L914L|NLRP3_uc001icw.2_Silent_p.L857L|NLRP3_uc001icv.2_Silent_p.L800L|NLRP3_uc010pyw.1_Silent_p.L892L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	914	LRR 7.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ATCAGAATCTCACGCACCTTT	0.517													0	0	0	0.003271	0	34	31										G	247607346	C	G	247607346	2	3	29	1	0	0	0	0	0	0	0	1	10478	813	29	1		1	NLRP3	1	247607346	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2588604	247607346	1643275	20	8016										
RNF103	7844	broad.mit.edu	37	chr2	86832395	86832395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggttttgatccgagaagctGcatgagcagttatccattta	10	7	0	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:86832395G>A	uc002srn.2	-	4	1598	c.629C>T	c.(628-630)GCA>GTA	p.A210V	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.A71V|uc002sro.2_Intron	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	210					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						CCGAGAAGCTGCATGAGCAGT	0.343													0	0	0	0.00361	0	82	75										A	86832395	G	A	86832395	3	1	29	1	0	0	0	0	1	0	0	0	13423	1319	46	2	1432	2	RNF103	2	86832395	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		86832395	156366978	21	8017										
RMND5A	64795	broad.mit.edu	37	chr2	86992169	86992169	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggtgggcagtgtcaaaccggGaaatgcttatagctcaaaac	12	8	2	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:86992169G>A	uc010ytm.1	+	5	918	c.541G>A	c.(541-543)GAA>AAA	p.E181K	RMND5A_uc002srs.3_Intron|RMND5A_uc002srr.2_Missense_Mutation_p.E181K	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	181	CTLH.			E -> G (in Ref. 1; BAB14257).						ovary(1)|skin(1)	2						GTCAAACCGGGAAATGCTTAT	0.373													0	0	0	0.007835	0	34	40										A	86992169	G	A	86992169	3	1	29	1	0	0	0	0	1	0	0	0	13397	1175	41	1	559	1	RMND5A	2	86992169	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	159774	86992169	156207204	22	8018										
RMND5A	64795	broad.mit.edu	37	chr2	86992260	86992260	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gggtggaaccacaaatcagcGagaggcattacaatatgcta	11	8	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:86992260G>A	uc010ytm.1	+	5	1009	c.632G>A	c.(631-633)CGA>CAA	p.R211Q	RMND5A_uc002srs.3_Intron|RMND5A_uc002srr.2_Missense_Mutation_p.R211Q	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	211										ovary(1)|skin(1)	2						ACAAATCAGCGAGAGGCATTA	0.368													0	0	0	0.005524	0	38	39										A	86992260	G	A	86992260	3	1	29	1	0	0	0	0	1	0	0	0	13397	1058	37	1	650	1	RMND5A	2	86992260	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	91	86992260	156207113	23	8019										
ANKRD39	51239	broad.mit.edu	37	chr2	97514175	97514175	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gatgtccccgtgacccctctCagcagcctgtggagagaaag	12	13	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:97514175C>T	uc002sxd.3	-	4	447	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_016466	NP_057550	Q53RE8	ANR39_HUMAN	ankyrin repeat domain 39	139	ANK 4.										0						TGACCCCTCTCAGCAGCCTGT	0.582													0	0	0	0.00361	0	45	39										T	97514175	C	T	97514175	3	4	29	1	0	0	0	0	1	0	0	0	668	835	29	1	140	1	ANKRD39	2	97514175	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	10521915	97514175	145685198	24	8020										
AFF3	3899	broad.mit.edu	37	chr2	100199373	100199373	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gctggaagaagttaagtcctCgctggtgtatttgtgtttag	13	5	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:100199373C>T	uc002tag.2	-	16	2916	c.2680G>A	c.(2680-2682)GAG>AAG	p.E894K	AFF3_uc002taf.2_Missense_Mutation_p.E919K|AFF3_uc010fiq.1_Missense_Mutation_p.E894K|AFF3_uc010yvr.1_Missense_Mutation_p.E1047K|AFF3_uc002tah.1_Missense_Mutation_p.E919K	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	894					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GTTAAGTCCTCGCTGGTGTAT	0.463													0	0	0	0.003214	0	47	44										T	100199373	C	T	100199373	3	4	29	1	0	0	0	0	1	0	0	0	358	893	31	1	1036	1	AFF3	2	100199373	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2685198	100199373	143000000	25	8021										
TTN	7273	broad.mit.edu	37	chr2	179612753	179612753	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atcctgctttggaaatgctgCcaactctggttctagagtgc	10	10	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:179612753C>A	uc002unb.2	-	46	14598	c.14374G>T	c.(14374-14376)GCA>TCA	p.A4792S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAAATGCTGCCAACTCTGGT	0.458													1	0	3.73988e-18	0.00632	4.42442e-18	30	29										A	179612753	C	A	179612753	3	1	29	1	0	0	0	0	1	0	0	0	16732	739	26	4	95923	4	TTN	2	179612753	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	79413380	179612753	63586620	26	8022										
CERKL	375298	broad.mit.edu	37	chr2	182413568	182413568	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtgctgaaggtgcagacgtcGaccagctgtacatgcccttg	13	11	0	2	rs139270710		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:182413568G>A	uc002unx.2	-	8	1091	c.990C>T	c.(988-990)GTC>GTT	p.V330V	CERKL_uc002uny.2_Silent_p.V304V|CERKL_uc010zfm.1_Silent_p.V286V|CERKL_uc002unz.2_Silent_p.V52V|CERKL_uc002uoa.2_Silent_p.V235V|CERKL_uc002uob.2_Silent_p.V52V|CERKL_uc002uoc.2_Silent_p.V191V|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Silent_p.V99V|CERKL_uc002uoe.2_Silent_p.V304V|CERKL_uc002unw.2_5'Flank	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	330	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TGCAGACGTCGACCAGCTGTA	0.428													0	0	0	0.003954	0	22	34										A	182413568	G	A	182413568	2	1	29	1	0	0	0	0	0	0	0	1	3268	1045	37	1		1	CERKL	2	182413568	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	2800815	182413568	60785805	27	8023										
KIF1A	547	broad.mit.edu	37	chr2	241726723	241726723	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cgttgatccgagagaagaggTcctcgcagagctgcaggaat	14	9	0	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:241726723T>C	uc002vzy.2	-	5	520	c.374A>G	c.(373-375)GAC>GGC	p.D125G	KIF1A_uc010fzk.2_Missense_Mutation_p.D125G|KIF1A_uc002vzz.1_Missense_Mutation_p.D125G	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	125	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AGAGAAGAGGTCCTCGCAGAG	0.657													0	0	0	0.002445	0	31	43										C	241726723	T	C	241726723	3	2	29	1	0	0	0	0	1	0	0	0	8283	1667	58	5	4870	5	KIF1A	2	241726723	Missense_Mutation	SNP	T	TCGA-CF-A27C-01A-11D-A16O-08	59313155	241726723	1472650	28	8024										
CNTN6	27255	broad.mit.edu	37	chr3	1424976	1424976	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atgtctttctctggatggtaGaacctcaactggccccaagg	10	11	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:1424976G>C	uc003boz.2	+	19	2669	c.2402_splice	c.e19-1	p.E801_splice	CNTN6_uc011asj.1_Splice_Site_p.E729_splice|CNTN6_uc003bpa.2_Splice_Site_p.E801_splice	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor						axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTGGATGGTAGAACCTCAACT	0.428													0	0	0	0.00361	0	91	135										C	1424976	G	C	1424976	5	2	29	1	0	0	0	0	0	0	1	0	3645	956	33	1	2471	1	CNTN6	3	1424976	Splice_Site	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		1424976	196597454	29	8025										
ROBO2	6092	broad.mit.edu	37	chr3	77614213	77614213	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tacttattcatggtcagagcGatcaacccccaaggtctcag	8	12	4	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:77614213G>A	uc003dpy.3	+	12	2434	c.1791G>A	c.(1789-1791)GCG>GCA	p.A597A	ROBO2_uc003dpz.2_Silent_p.A601A|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.A601A	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	597	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGGTCAGAGCGATCAACCCCC	0.498													0	0	0	0.00361	0	57	70										A	77614213	G	A	77614213	2	1	29	1	0	0	0	0	0	0	0	1	13514	1045	37	1		1	ROBO2	3	77614213	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	76189237	77614213	120408217	30	8026										
RAB7A	7879	broad.mit.edu	37	chr3	128525358	128525358	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggagagatgagtttctcatCcaggccagtccccgagatcc	11	12	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:128525358C>T	uc003eks.1	+	4	556	c.324C>T	c.(322-324)ATC>ATT	p.I108I	RAB7A_uc010hsv.1_Intron|RAB7A_uc003ekt.2_Silent_p.I84I	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	108				I -> V (in Ref. 2; AAA86640).	endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)		AGTTTCTCATCCAGGCCAGTC	0.458													0	0	0	0.005524	0	37	42										T	128525358	C	T	128525358	2	4	29	1	0	0	0	0	0	0	0	1	12954	845	30	1		1	RAB7A	3	128525358	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	50911145	128525358	69497072	31	8027										
IGSF10	285313	broad.mit.edu	37	chr3	151166216	151166216	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cctcactgacataaggggctCtcactttacttccatcagct	6	14	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:151166216C>G	uc011bod.1	-	4	1553	c.1553G>C	c.(1552-1554)AGA>ACA	p.R518T		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	518	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATAAGGGGCTCTCACTTTACT	0.498													0	0	0	0.00361	0	103	108										G	151166216	C	G	151166216	3	3	29	1	0	0	0	0	1	0	0	0	7597	913	32	1	6378	1	IGSF10	3	151166216	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	22640858	151166216	46856214	32	8028										
IGSF10	285313	broad.mit.edu	37	chr3	151166508	151166508	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agagggatctgctctgagatCtgcctctatgttggtaaaaa	11	7	4	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:151166508C>G	uc011bod.1	-	4	1261	c.1261G>C	c.(1261-1263)GAT>CAT	p.D421H		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	421					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTCTGAGATCTGCCTCTATG	0.438													0	0	0	0.004289	0	37	35										G	151166508	C	G	151166508	3	3	29	1	0	0	0	0	1	0	0	0	7597	913	32	1	6670	1	IGSF10	3	151166508	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	292	151166508	46855922	33	8029										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	WGS			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.001523	0	16	19										G	1803568	C	G	1803568	3	3	29	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		1803568	189350708	34	8030										
RGS12	6002	broad.mit.edu	37	chr4	3416499	3416499	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gattttctaaggaaagaattCagtgaagaaaacattttatt	7	3	2	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:3416499C>T	uc003ggw.2	+	6	3115	c.2211C>T	c.(2209-2211)TTC>TTT	p.F737F	RGS12_uc003ggu.2_Silent_p.F737F|RGS12_uc010ics.1_5'UTR|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Silent_p.F737F|RGS12_uc003ggy.1_Silent_p.F135F|RGS12_uc010ict.1_Silent_p.F89F|RGS12_uc003ggz.2_Silent_p.F89F|RGS12_uc010icu.1_5'UTR|RGS12_uc011bvs.1_Silent_p.F79F|RGS12_uc003gha.2_Silent_p.F79F|RGS12_uc010icv.2_5'UTR|RGS12_uc003ghb.2_5'UTR	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	737	RGS.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGAAAGAATTCAGTGAAGAAA	0.413													0	0	0	0.00361	0	48	169										T	3416499	C	T	3416499	2	4	29	1	0	0	0	0	0	0	0	1	13295	825	29	1		1	RGS12	4	3416499	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	1612931	3416499	187737777	35	8031										
WDR1	9948	broad.mit.edu	37	chr4	10100690	10100690	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atgtctttgatcttcccagcGaaaggctggtactcatactt	8	10	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:10100690G>A	uc003gmf.2	-	4	586	c.303C>T	c.(301-303)TTC>TTT	p.F101F	WDR1_uc003gmg.2_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	101	WD 2.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TCTTCCCAGCGAAAGGCTGGT	0.577													0	0	0	0.00361	0	74	75										A	10100690	G	A	10100690	2	1	29	1	0	0	0	0	0	0	0	1	17269	1049	37	1		1	WDR1	4	10100690	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	6684191	10100690	181053586	36	8032										
HS3ST1	9957	broad.mit.edu	37	chr4	11401132	11401132	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gacgggtagggcttgtgcttCtgcatgtggttgtagaacac	15	7	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:11401132C>T	uc003gmq.2	-	2	821	c.498G>A	c.(496-498)CAG>CAA	p.Q166Q		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	166						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						GCTTGTGCTTCTGCATGTGGT	0.587													0	0	0	0.00361	0	43	53										T	11401132	C	T	11401132	2	4	29	1	0	0	0	0	0	0	0	1	7363	912	32	1		1	HS3ST1	4	11401132	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	1300442	11401132	179753144	37	8033										
SHROOM3	57619	broad.mit.edu	37	chr4	77675497	77675497	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tcagaaagaggccaagaagaGatgctgccgctcttccacca	10	12	2	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:77675497G>C	uc011cbx.1	+	7	4814	c.3861G>C	c.(3859-3861)GAG>GAC	p.E1287D	SHROOM3_uc003hkg.2_Missense_Mutation_p.E1065D	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1287					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCCAAGAAGAGATGCTGCCGC	0.547													0	0	0	0.00361	0	81	113										C	77675497	G	C	77675497	3	2	29	1	0	0	0	0	1	0	0	0	14295	933	33	1	3887	1	SHROOM3	4	77675497	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	66274365	77675497	113478779	38	8034										
TIGD2	166815	broad.mit.edu	37	chr4	90034853	90034853	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	attcaaaggcactgacctttCaaaccttcctgtgacatatt	5	11	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:90034853C>G	uc003hsk.2	+	1	886	c.728C>G	c.(727-729)TCA>TGA	p.S243*	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	243	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		ACTGACCTTTCAAACCTTCCT	0.423													0	0	0	0.008361	0	30	32										G	90034853	C	G	90034853	4	3	29	1	0	0	0	0	0	1	0	0	15893	838	29	1	730	1	TIGD2	4	90034853	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	12359356	90034853	101119423	39	8035										
MTTP	4547	broad.mit.edu	37	chr4	100510816	100510816	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccaggtcaaagagttctactCatatcaaaatgaggcagtgg	10	8	4	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:100510816C>G	uc003hvc.3	+	5	666	c.410C>G	c.(409-411)TCA>TGA	p.S137*	MTTP_uc011cej.1_Nonsense_Mutation_p.S164*	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	137	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GAGTTCTACTCATATCAAAAT	0.418													0	0	0	0.007413	0	16	18										G	100510816	C	G	100510816	4	3	29	1	0	0	0	0	0	1	0	0	9964	838	29	1	424	1	MTTP	4	100510816	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	10475963	100510816	90643460	40	8036										
TRPC3	7222	broad.mit.edu	37	chr4	122831316	122831316	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gctaacaacttaccataagtGaaatactgtatctctggtgg	8	8	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:122831316G>A	uc003ieg.2	-	6	1859	c.1785C>T	c.(1783-1785)TTC>TTT	p.F595F	TRPC3_uc010inr.2_Silent_p.F467F|TRPC3_uc003ief.2_Silent_p.F522F|TRPC3_uc011cgl.1_Silent_p.F259F	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	510	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TACCATAAGTGAAATACTGTA	0.438													0	0	0	0.002096	0	31	56										A	122831316	G	A	122831316	2	1	29	1	0	0	0	0	0	0	0	1	16576	1281	45	1		1	TRPC3	4	122831316	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	22320500	122831316	68322960	41	8037										
BBS12	166379	broad.mit.edu	37	chr4	123664339	123664339	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aaaatgtataaacagtaagcGgttggtaatcggctcagtga	11	5	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:123664339G>A	uc003ieu.2	+	2	1485	c.1292G>A	c.(1291-1293)CGG>CAG	p.R431Q		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	431					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						AACAGTAAGCGGTTGGTAATC	0.443									Bardet-Biedl_syndrome				0	0	0	0.00361	0	50	44										A	123664339	G	A	123664339	3	1	29	1	0	0	0	0	1	0	0	0	1337	1116	39	2	1294	2	BBS12	4	123664339	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	833023	123664339	67489937	42	8038										
GAB1	2549	broad.mit.edu	37	chr4	144361407	144361407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atttgatttttcctcatttgGaatgcaagttcctcctcctg	6	10	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:144361407G>A	uc003ije.2	+	6	1816	c.1457G>A	c.(1456-1458)GGA>GAA	p.G486E	GAB1_uc003ijd.2_Missense_Mutation_p.G486E|GAB1_uc011chq.1_Missense_Mutation_p.G383E	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	486	Pro-rich.				cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					TCCTCATTTGGAATGCAAGTT	0.483													0	0	0	0.003214	0	47	35										A	144361407	G	A	144361407	3	1	29	1	0	0	0	0	1	0	0	0	6148	1174	41	1	1479	1	GAB1	4	144361407	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	20697068	144361407	46792869	43	8039										
ZNF827	152485	broad.mit.edu	37	chr4	146686180	146686180	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agtgtggcatttcttatgctCcagcagctgttcgggggtct	13	9	2	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:146686180C>G	uc003ikn.2	-	13	3238	c.3190G>C	c.(3190-3192)GAG>CAG	p.E1064Q	ZNF827_uc003ikm.2_Missense_Mutation_p.E1064Q|ZNF827_uc010iox.2_Missense_Mutation_p.E714Q|ZNF827_uc003ikl.2_Missense_Mutation_p.E149Q	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	1064	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TTCTTATGCTCCAGCAGCTGT	0.483													0	0	0	0.004672	0	3	162										G	146686180	C	G	146686180	3	3	29	1	0	0	0	0	1	0	0	0	18177	864	30	1	47	1	ZNF827	4	146686180	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2324773	146686180	44468096	44	8040										
DDX60	55601	broad.mit.edu	37	chr4	169196559	169196559	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tcttttctctcatctcgtatCaaataatggcccatgtattg	5	10	5	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:169196559C>T	uc003irp.2	-	16	2533	c.2241G>A	c.(2239-2241)TTG>TTA	p.L747L		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	747							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CATCTCGTATCAAATAATGGC	0.403													0	0	0	0.002096	0	30	26										T	169196559	C	T	169196559	2	4	29	1	0	0	0	0	0	0	0	1	4378	825	29	1		1	DDX60	4	169196559	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	22510379	169196559	21957717	45	8041										
GALNT7	51809	broad.mit.edu	37	chr4	174169341	174169341	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atatcatgcagaggcagtatCtcacatttaagcctcagaca	7	10	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:174169341C>G	uc003isz.3	+	2	420	c.337C>G	c.(337-339)CTC>GTC	p.L113V		NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	113	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		GAGGCAGTATCTCACATTTAA	0.463													0	0	0	0.001786	0	32	40										G	174169341	C	G	174169341	3	3	29	1	0	0	0	0	1	0	0	0	6218	913	32	1	343	1	GALNT7	4	174169341	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	4972782	174169341	16984935	46	8042										
ASB5	140458	broad.mit.edu	37	chr4	177143510	177143510	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggcacatgccacgtgatctCcaaggcaggcttcgtgcaat	11	12	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:177143510C>G	uc003iuq.1	-	3	354	c.338G>C	c.(337-339)GGA>GCA	p.G113A	ASB5_uc003iup.1_Missense_Mutation_p.G60A	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	113	ANK 2.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		CACGTGATCTCCAAGGCAGGC	0.423													0	0	0	0.001786	0	30	31										G	177143510	C	G	177143510	3	3	29	1	0	0	0	0	1	0	0	0	1026	855	30	1	671	1	ASB5	4	177143510	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2974169	177143510	14010766	47	8043										
FAT1	2195	broad.mit.edu	37	chr4	187518864	187518864	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cctaaaacccgaatcacactGacaaacggcgccatccaaac	5	16	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:187518864G>A	uc003izf.2	-	24	12528	c.12340C>T	c.(12340-12342)CAG>TAG	p.Q4114*	FAT1_uc010isn.2_5'Flank|FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4114	Extracellular (Potential).|EGF-like 4.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAATCACACTGACAAACGGCG	0.428										HNSCC(5;0.00058)			0	0	0	0.003954	0	23	29										A	187518864	G	A	187518864	4	1	29	1	0	0	0	0	0	1	0	0	5689	1299	45	1	1442	1	FAT1	4	187518864	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	10375354	187518864	3635412	48	8044										
RASGRF2	5924	broad.mit.edu	37	chr5	80422929	80422929	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tgcccactgctctgtttcacCggcttctgcttttgcaatag	8	13	3	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:80422929C>T	uc003kha.1	+	17	2633	c.2633C>T	c.(2632-2634)CCG>CTG	p.P878L	RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	878					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TCTGTTTCACCGGCTTCTGCT	0.448													0	0	0	0.003954	0	25	41										T	80422929	C	T	80422929	3	4	29	1	0	0	0	0	1	0	0	0	13073	652	23	2	2699	2	RASGRF2	5	80422929	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		80422929	100492331	49	8045										
GDF9	2661	broad.mit.edu	37	chr5	132200111	132200111	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	catagccccagattccaactCagcactagcagcaatctgag	7	14	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:132200111C>T	uc003kxz.1	-	1	367	c.115G>A	c.(115-117)GAG>AAG	p.E39K	GDF9_uc011cxj.1_Intron|UQCRQ_uc003kya.1_5'Flank	NM_005260	NP_005251	O60383	GDF9_HUMAN	growth differentiation factor 9 precursor	39					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			skin(1)	1		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GATTCCAACTCAGCACTAGCA	0.502													0	0	0	0.00361	0	56	61										T	132200111	C	T	132200111	3	4	29	1	0	0	0	0	1	0	0	0	6319	835	29	1	1257	1	GDF9	5	132200111	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	51777182	132200111	48715149	50	8046										
PCDHB14	56122	broad.mit.edu	37	chr5	140604577	140604577	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	caggaccggcacctgcccctCgcctccttggtctccatcaa	8	19	2	0	rs142260227		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:140604577C>A	uc003ljb.2	+	1	1500	c.1500C>A	c.(1498-1500)CTC>CTA	p.L500L	PCDHB14_uc011dal.1_Silent_p.L347L	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	500	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTGCCCCTCGCCTCCTTGG	0.652													1	0	3.06722e-38	0.00361	3.7285e-38	93	91										A	140604577	C	A	140604577	2	1	29	1	0	0	0	0	0	0	0	1	11539	871	31	3		3	PCDHB14	5	140604577	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	8404466	140604577	40310683	51	8047										
PCDHGB3	56102	broad.mit.edu	37	chr5	140750327	140750327	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttttttcatgtaactgtgctGatccaggatattaacgacaa	7	7	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:140750327G>A	uc003ljw.1	+	1	366	c.366G>A	c.(364-366)CTG>CTA	p.L122L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Silent_p.L122L	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	122	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAACTGTGCTGATCCAGGATA	0.443													0	0	0	0.00361	0	127	107										A	140750327	G	A	140750327	2	1	29	1	0	0	0	0	0	0	0	1	11564	1277	45	1		1	PCDHGB3	5	140750327	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	145750	140750327	40164933	52	8048										
PCDHGB7	56099	broad.mit.edu	37	chr5	140798486	140798486	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	taatcatcacgtcactctctGatcagattatggaggattcc	7	10	5	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:140798486G>C	uc003lkn.1	+	1	1205	c.1060G>C	c.(1060-1062)GAT>CAT	p.D354H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.D354H|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	354	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCACTCTCTGATCAGATTAT	0.463													0	0	0	0.008361	0	26	26										C	140798486	G	C	140798486	3	2	29	1	0	0	0	0	1	0	0	0	11568	1290	45	1	1062	1	PCDHGB7	5	140798486	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	48159	140798486	40116774	53	8049										
ODZ2	57451	broad.mit.edu	37	chr5	167553852	167553852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aggcgcagcgtgtgaccagcGcgtgtgccacccccgctgca	14	16	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:167553852G>A	uc010jjd.2	+	12	2303	c.2303G>A	c.(2302-2304)CGC>CAC	p.R768H	ODZ2_uc003lzr.3_Missense_Mutation_p.R536H|ODZ2_uc003lzt.3_Missense_Mutation_p.R132H|ODZ2_uc010jje.2_Missense_Mutation_p.R39H|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGTGACCAGCGCGTGTGCCAC	0.602													0	0	0	0.003163	0	14	7										A	167553852	G	A	167553852	3	1	29	1	0	0	0	0	1	0	0	0	10835	1087	38	2	2349	2	ODZ2	5	167553852	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	26755366	167553852	13361408	54	8050										
STK10	6793	broad.mit.edu	37	chr5	171471888	171471888	+	Nonstop_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cacagccccgggcggttgttAagaagcatccgcagaactgt	12	12	0	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:171471888A>C	uc003mbo.1	-	19	3205	c.2905T>G	c.(2905-2907)TAA>GAA	p.*969E		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	969							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGCGGTTGTTAAGAAGCATCC	0.592													0	0	0	0.00361	0	47	52										C	171471888	A	C	171471888	4	2	29	1	0	0	0	0	0	0	0	0	15285	375	13	5	5	5	STK10	5	171471888	Nonstop_Mutation	SNP	A	TCGA-CF-A27C-01A-11D-A16O-08	3918036	171471888	9443372	55	8051										
OR2V2	285659	broad.mit.edu	37	chr5	180582343	180582343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tagccacccacttcactatcCcatcctcatgaatcagaggg	6	15	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:180582343C>T	uc011dhj.1	+	1	401	c.401C>T	c.(400-402)CCC>CTC	p.P134L		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P134T(1)		ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTCACTATCCCATCCTCATG	0.502													0	0	0	0.00361	0	56	72										T	180582343	C	T	180582343	3	4	29	1	0	0	0	0	1	0	0	0	11031	623	22	2	403	2	OR2V2	5	180582343	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	9110455	180582343	332917	56	8052										
TRIM7	81786	broad.mit.edu	37	chr5	180625764	180625764	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agactttattcttcatctcaGaagagactgtggttggcttg	10	7	3	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:180625764G>C	uc003mmz.1	-	5	981	c.914C>G	c.(913-915)TCT>TGT	p.S305C	TRIM7_uc003mmv.1_Missense_Mutation_p.S123C|TRIM7_uc003mmw.1_Missense_Mutation_p.S97C|TRIM7_uc003mmx.1_Missense_Mutation_p.S97C|TRIM7_uc003mmy.1_Missense_Mutation_p.S97C	NM_203293	NP_976038	Q9C029	TRIM7_HUMAN	tripartite motif-containing 7 isoform 1	305						cytoplasm|nucleus	zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		CTTCATCTCAGAAGAGACTGT	0.527													0	0	0	0.004007	0	15	22										C	180625764	G	C	180625764	3	2	29	1	0	0	0	0	1	0	0	0	16540	942	33	1	633	1	TRIM7	5	180625764	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	43421	180625764	289496	57	8053										
KIF13A	63971	broad.mit.edu	37	chr6	17777582	17777582	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aagtgcttctttgactgtgaCggcctgtaaacataataatt	8	7	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:17777582C>T	uc003ncg.3	-	34	4201	c.4096G>A	c.(4096-4098)GTC>ATC	p.V1366I	KIF13A_uc003ncf.2_Missense_Mutation_p.V1353I|KIF13A_uc003nch.3_Missense_Mutation_p.V1366I|KIF13A_uc003nci.3_Missense_Mutation_p.V1353I|KIF13A_uc003nce.1_5'UTR	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1366					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTGACTGTGACGGCCTGTAAA	0.294													0	0	0	0.000248	0	4	28										T	17777582	C	T	17777582	3	4	29	1	0	0	0	0	1	0	0	0	8274	536	19	2	1370	2	KIF13A	6	17777582	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		17777582	153337485	58	8054										
RPS18	6222	broad.mit.edu	37	chr6	33243640	33243640	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttgacctcaccaagagggcgGgagaactcactgaggatgag	14	9	2	5	rs3208874		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:33243640G>A	uc003odp.1	+	3	214	c.169G>A	c.(169-171)GGA>AGA	p.G57R	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	57					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						CAAGAGGGCGGGAGAACTCAC	0.552													0	0	0	0.000248	0	4	152										A	33243640	G	A	33243640	3	1	29	1	0	0	0	0	1	0	0	0	13628	1233	43	2	179	2	RPS18	6	33243640	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	15466058	33243640	137871427	59	8055										
CDKN1A	1026	broad.mit.edu	37	chr6	36651923	36651930	+	Frame_Shift_Del	DEL	CAAGGCCT	CAAGGCCT	-													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cgtcagaacccatgcggcagCaaggcctgccgccgcctctt							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08			CAAGGCCT	-	CAAGGCCT	CAAGGCCT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:36651923_36651930delCAAGGCCT	uc003omm.3	+	2	167_174	c.45_52delCAAGGCCT	c.(43-54)AGCAAGGCCTGCfs	p.S15fs	CDKN1A_uc011dtq.1_Frame_Shift_Del_p.S49fs|CDKN1A_uc003oml.2_Frame_Shift_Del_p.S15fs|CDKN1A_uc003omn.2_Frame_Shift_Del_p.S15fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	15_18	Required for binding cyclins.|C4-type (Potential).				cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						CATGCGGCAGCAAGGCCTGCCGCCGCCT	0.635									Multiple_Endocrine_Neoplasia_type_1									11	1	---	---								-	36651930	CAAGGCCT	-	36651923	7	5	29	1	0	1	0	1	0	0	0	0	3158	709	25	0	47	0	CDKN1A	6	36651923	Frame_Shift_Del	DEL	CAAGGCCT	TCGA-CF-A27C-01A-11D-A16O-08	3408283	36651923	134463144	60	8056										
RPL7L1	285855	broad.mit.edu	37	chr6	42848633	42848633	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctttggttccagaaaatctcCtgaaaaagaggaaggcttat	9	7	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:42848633C>G	uc003osq.1	+	2	54	c.49C>G	c.(49-51)CTG>GTG	p.L17V	RPL7L1_uc011dux.1_Missense_Mutation_p.L17V|RPL7L1_uc010jxw.1_Intron|RPL7L1_uc003osr.1_5'UTR|RPL7L1_uc011duy.1_Missense_Mutation_p.L17V|RPL7L1_uc003oss.1_Intron|RPL7L1_uc003ost.2_Missense_Mutation_p.L17V|RPL7L1_uc003osu.2_RNA	NM_198486	NP_940888	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	17					translation	large ribosomal subunit	protein binding|structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			AGAAAATCTCCTGAAAAAGAG	0.378													0	0	0	0.00874	0	40	27										G	42848633	C	G	42848633	3	3	29	1	0	0	0	0	1	0	0	0	13601	680	24	4	55	4	RPL7L1	6	42848633	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	6196710	42848633	128266434	61	8057										
MEP1A	4224	broad.mit.edu	37	chr6	46806751	46806751	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atgctttcttctacacggggGagcgctgtcaggccgtgcag	14	11	3	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:46806751G>T	uc010jzh.1	+	14	2161	c.2119G>T	c.(2119-2121)GAG>TAG	p.E707*	MEP1A_uc011dwg.1_Nonsense_Mutation_p.E429*|MEP1A_uc011dwh.1_Nonsense_Mutation_p.E735*|MEP1A_uc011dwi.1_Nonsense_Mutation_p.E607*	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	707	EGF-like.|Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CTACACGGGGGAGCGCTGTCA	0.587													1	0	2.61895e-37	0.00361	3.16905e-37	82	87										T	46806751	G	T	46806751	4	4	29	1	0	0	0	0	0	1	0	0	9475	1175	41	3	2173	3	MEP1A	6	46806751	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3958118	46806751	124308316	62	8058										
ENPP3	5169	broad.mit.edu	37	chr6	131971180	131971180	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tttgtaggcagctgcaggaaGaagtgctttgatgcatcatt	12	6	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:131971180G>A	uc003qcu.3	+	4	515	c.168G>A	c.(166-168)AAG>AAA	p.K56K	ENPP3_uc010kfn.1_RNA|ENPP3_uc011ecc.1_Silent_p.K22K|ENPP3_uc010kfo.1_RNA|ENPP3_uc010kfp.1_RNA|ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.K56K	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	56	Extracellular (Potential).|SMB 1.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GCTGCAGGAAGAAGTGCTTTG	0.463													0	0	0	0.00623	0	41	55										A	131971180	G	A	131971180	2	1	29	1	0	0	0	0	0	0	0	1	5131	933	33	1		1	ENPP3	6	131971180	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	85164429	131971180	39143887	63	8059										
TAAR6	319100	broad.mit.edu	37	chr6	132891943	132891943	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtgtcctggatcctgcccctCatgtacagcggtgctgtgtt	12	12	1	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:132891943C>A	uc011eck.1	+	1	483	c.483C>A	c.(481-483)CTC>CTA	p.L161L		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	161	Helical; Name=4; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TCCTGCCCCTCATGTACAGCG	0.502													1	0	2.98797e-67	0.00361	3.6489e-67	155	154										A	132891943	C	A	132891943	2	1	29	1	0	0	0	0	0	0	0	1	15489	813	29	3		3	TAAR6	6	132891943	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	920763	132891943	38223124	64	8060										
TAB2	23118	broad.mit.edu	37	chr6	149700620	149700620	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ataagtgaaacacggaaactGagtatgggatctgatgatgc	12	5	1	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:149700620G>C	uc003qmj.2	+	3	1747	c.1569G>C	c.(1567-1569)CTG>CTC	p.L523L	TAB2_uc011eec.1_Silent_p.L491L|TAB2_uc010kia.1_Silent_p.L523L|TAB2_uc010kib.1_Silent_p.L523L|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	523					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						CACGGAAACTGAGTATGGGAT	0.413													0	0	0	0.003271	0	35	31										C	149700620	G	C	149700620	2	2	29	1	0	0	0	0	0	0	0	1	15493	1277	45	1		1	TAB2	6	149700620	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	16808677	149700620	21414447	65	8061										
HOXA2	3199	broad.mit.edu	37	chr7	27140803	27140803	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cgtcttctcttcctcgtcctCctctactttctcggagtcct	5	17	4	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:27140803C>T	uc003syh.2	-	2	948	c.673G>A	c.(673-675)GAG>AAG	p.E225K		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	225						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TCCTCGTCCTCCTCTACTTTC	0.517													0	0	0	0.00361	0	47	44										T	27140803	C	T	27140803	3	4	29	1	0	0	0	0	1	0	0	0	7292	864	30	1	461	1	HOXA2	7	27140803	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		27140803	131997860	66	8062										
TNS3	64759	broad.mit.edu	37	chr7	47453569	47453569	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtacacaggctgcatggcttGgtagagcttcagaaagggcc	14	9	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:47453569G>C	uc003tnv.2	-	12	980	c.613C>G	c.(613-615)CAA>GAA	p.Q205E	TNS3_uc003tnw.2_Missense_Mutation_p.Q205E|TNS3_uc010kyo.1_Missense_Mutation_p.Q205E	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	205	C2 tensin-type.					focal adhesion	protein binding			ovary(4)	4						TGCATGGCTTGGTAGAGCTTC	0.473													0	0	0	0.00361	0	61	84										C	47453569	G	C	47453569	3	2	29	1	0	0	0	0	1	0	0	0	16341	1357	47	4	3804	4	TNS3	7	47453569	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	20312766	47453569	111685094	67	8063										
ZPBP	11055	broad.mit.edu	37	chr7	50023061	50023061	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttgaggtaattgttctgcacGtctgccaagaatttctactt	8	8	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:50023061G>A	uc003tou.2	-	7	908	c.838C>T	c.(838-840)CGT>TGT	p.R280C	ZPBP_uc011kci.1_Missense_Mutation_p.R206C|ZPBP_uc010kyw.2_Missense_Mutation_p.R279C	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	280					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TGTTCTGCACGTCTGCCAAGA	0.323													0	0	0	0.00333	0	26	20										A	50023061	G	A	50023061	3	1	29	1	0	0	0	0	1	0	0	0	18216	1145	40	2	225	2	ZPBP	7	50023061	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	2569492	50023061	109115602	68	8064										
PCLO	27445	broad.mit.edu	37	chr7	82785410	82785410	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggtttcttcctgggatgcctCagagtctgatatcaaatcaa	9	9	5	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:82785410C>T	uc003uhx.2	-	2	836	c.547G>A	c.(547-549)GAG>AAG	p.E183K	PCLO_uc003uhv.2_Missense_Mutation_p.E183K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	183					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGGATGCCTCAGAGTCTGAT	0.418													0	0	0	0.002096	0	29	30										T	82785410	C	T	82785410	3	4	29	1	0	0	0	0	1	0	0	0	11583	835	29	1	14994	1	PCLO	7	82785410	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	32762349	82785410	76353253	69	8065										
PSMC2	5701	broad.mit.edu	37	chr7	103003152	103003152	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gcgtggatagaaataaatatCaaattcacattccattgcct	6	8	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:103003152C>G	uc003vbs.2	+	6	512	c.442C>G	c.(442-444)CAA>GAA	p.Q148E	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.Q11E	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	148					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AAATAAATATCAAATTCACAT	0.333													0	0	0	0.00361	0	52	4										G	103003152	C	G	103003152	3	3	29	1	0	0	0	0	1	0	0	0	12686	827	29	1	464	1	PSMC2	7	103003152	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	20217742	103003152	56135511	70	8066										
ST7	7982	broad.mit.edu	37	chr7	116849888	116849888	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctacccccagaacatatcctGaagagaggagacagtgaagc	10	11	0	5			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:116849888G>A	uc003vin.2	+	13	1516	c.1302G>A	c.(1300-1302)CTG>CTA	p.L434L	ST7_uc011knl.1_Silent_p.L411L|ST7_uc003vio.2_Silent_p.L411L|ST7_uc003viq.2_Silent_p.L388L|ST7_uc011knm.1_Silent_p.L391L|ST7_uc003vir.2_Silent_p.L359L|ST7_uc011knn.1_Silent_p.L382L|ST7OT3_uc003viy.1_RNA	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	434						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		AACATATCCTGAAGAGAGGAG	0.388													0	0	0	0.000248	0	4	33										A	116849888	G	A	116849888	2	1	29	1	0	0	0	0	0	0	0	1	15228	1277	45	1		1	ST7	7	116849888	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	13846736	116849888	42288775	71	8067										
STC1	6781	broad.mit.edu	37	chr8	23709043	23709043	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tctctttgacgaatgcttttCcctgccatggaggaaggaca	10	10	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:23709043C>A	uc003xdw.1	-	3	547	c.263G>T	c.(262-264)GGA>GTA	p.G88V		NM_003155	NP_003146	P52823	STC1_HUMAN	stanniocalcin 1 precursor	88					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			skin(3)|upper_aerodigestive_tract(1)	4		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GAATGCTTTTCCCTGCCATGG	0.507													1	0	4.36969e-10	0.001855	5.12375e-10	12	21										A	23709043	C	A	23709043	3	1	29	1	0	0	0	0	1	0	0	0	15274	869	30	3	488	3	STC1	8	23709043	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		23709043	122654979	72	8068										
PXDNL	137902	broad.mit.edu	37	chr8	52321351	52321351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gctctcctgctcctgtcgcgCgcactcggtgggtgggcctg	15	15	1	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:52321351C>T	uc003xqu.3	-	17	2934	c.2833G>A	c.(2833-2835)GCG>ACG	p.A945T	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	945					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCCTGTCGCGCGCACTCGGTG	0.647													0	0	0	0.000978	0	12	19										T	52321351	C	T	52321351	3	4	29	1	0	0	0	0	1	0	0	0	12848	768	27	2	1586	2	PXDNL	8	52321351	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	28612308	52321351	94042671	73	8069										
TMEM68	137695	broad.mit.edu	37	chr8	56675387	56675387	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agtggtgtaaaaacccacaaGagatagtttgcaaaattcaa	8	6	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:56675387G>C	uc003xsg.1	-	1	201	c.132C>G	c.(130-132)CTC>CTG	p.L44L	TMEM68_uc003xsh.1_Silent_p.L44L|TMEM68_uc003xsi.1_Silent_p.L44L	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	44						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			AAACCCACAAGAGATAGTTTG	0.338													0	0	0	0.00499	0	16	27										C	56675387	G	C	56675387	2	2	29	1	0	0	0	0	0	0	0	1	16194	929	33	1		1	TMEM68	8	56675387	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	4354036	56675387	89688635	74	8070										
EXT1	2131	broad.mit.edu	37	chr8	118842578	118842578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cctgatgaatagacctgattGtagaaggaatctgtaacaca	9	7	1	5			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:118842578G>A	uc003yok.1	-	4	1948	c.1175C>T	c.(1174-1176)ACA>ATA	p.T392I		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	392	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			AGACCTGATTGTAGAAGGAAT	0.353			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				0	0	0	0.004007	0	16	24										A	118842578	G	A	118842578	3	1	29	1	0	0	0	0	1	0	0	0	5323	1377	48	2	1097	2	EXT1	8	118842578	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	62167191	118842578	27521444	75	8071										
C8orf76	84933	broad.mit.edu	37	chr8	124253503	124253503	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agcttggcgcagtaggacgcGggcggtcctgaccgccgctc	16	14	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:124253503G>T	uc003yqc.1	-	1	115	c.84C>A	c.(82-84)CCC>CCA	p.P28P	C8orf76_uc003yqd.2_Intron	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	28							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTAGGACGCGGGCGGTCCTG	0.557													1	0	7.48243e-07	0.006214	8.69668e-07	10	9										T	124253503	G	T	124253503	2	4	29	1	0	0	0	0	0	0	0	1	2437	1103	39	4		4	C8orf76	8	124253503	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	5410925	124253503	22110519	76	8072										
SLC1A1	6505	broad.mit.edu	37	chr9	4585317	4585317	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cccgtctctccccagggaccGgttcaggaccatggtcaacg	11	16	3	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:4585317G>A	uc003zij.1	+	12	1570	c.1334G>A	c.(1333-1335)CGG>CAG	p.R445Q	C9orf68_uc003zik.2_Intron	NM_004170	NP_004161	P43005	EAA3_HUMAN	solute carrier family 1, member 1	445					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CCCAGGGACCGGTTCAGGACC	0.507													0	0	0	0.002096	0	30	59										A	4585317	G	A	4585317	3	1	29	1	0	0	0	0	1	0	0	0	14431	1116	39	2	1380	2	SLC1A1	9	4585317	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		4585317	136628114	77	8073										
ZDHHC21	340481	broad.mit.edu	37	chr9	14674276	14674276	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atattgtataaccaaacaaaGacaatcaaacccatgcagca	4	10	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:14674276G>A	uc003zli.2	-	4	533	c.63C>T	c.(61-63)GTC>GTT	p.V21V	ZDHHC21_uc003zlg.1_Intron	NM_178566	NP_848661	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	21	Helical; (Potential).				nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(50;4.31e-06)		ACCAAACAAAGACAATCAAAC	0.378													0	0	0	0.004672	0	3	45										A	14674276	G	A	14674276	2	1	29	1	0	0	0	0	0	0	0	1	17609	942	33	1		1	ZDHHC21	9	14674276	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	10088959	14674276	126539155	78	8074										
PSIP1	11168	broad.mit.edu	37	chr9	15468842	15468842	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctaactttgaatcgccgtatCtgagaaaacaatatacattc	5	9	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:15468842C>G	uc003zlv.3	-	14	1537	c.1207_splice	c.e14-1	p.I403_splice	PSIP1_uc003zlw.3_Splice_Site_p.I403_splice	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		ATCGCCGTATCTGAGAAAACA	0.299													0	0	0	0.008871	0	20	3										G	15468842	C	G	15468842	5	3	29	1	0	0	0	0	0	0	1	0	12663	927	32	1	398	1	PSIP1	9	15468842	Splice_Site	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	794566	15468842	125744589	79	8075										
FAM189A2	9413	broad.mit.edu	37	chr9	71990748	71990748	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccttgaaactctttccggttCagccctgtagtgctgttcac	8	13	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:71990748C>T	uc010mon.1	+	4	324	c.220C>T	c.(220-222)CAG>TAG	p.Q74*	FAM189A2_uc004ahg.2_Nonsense_Mutation_p.Q74*|FAM189A2_uc010moo.1_5'UTR	NM_001127608	NP_001121080	Q15884	F1892_HUMAN	chromosome 9 open reading frame 61 precursor	74						integral to membrane					0						CTTTCCGGTTCAGCCCTGTAG	0.463													0	0	0	0.00361	0	57	4										T	71990748	C	T	71990748	4	4	29	1	0	0	0	0	0	1	0	0	5516	827	29	1	230	1	FAM189A2	9	71990748	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	56521906	71990748	69222683	80	8076										
HSD17B3	3293	broad.mit.edu	37	chr9	98997817	98997817	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctttggaaggcaccgctgtaGaaggcccaggccgggatcag	15	11	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:98997817G>C	uc004awa.1	-	11	906	c.858C>G	c.(856-858)TTC>TTG	p.F286L	HSD17B3_uc010msc.1_Missense_Mutation_p.F236L	NM_000197	NP_000188	P37058	DHB3_HUMAN	estradiol 17 beta-dehydrogenase 3	286					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity				0		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	CACCGCTGTAGAAGGCCCAGG	0.537													0	0	0	0.001882	0	18	0										C	98997817	G	C	98997817	3	2	29	1	0	0	0	0	1	0	0	0	7385	933	33	1	78	1	HSD17B3	9	98997817	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	27007069	98997817	42215614	81	8077										
MSRB2	22921	broad.mit.edu	37	chr10	23399191	23399191	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cctttcagtgggatctacctGaataacaaggaagcaggaat	10	8	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:23399191G>T	uc001iro.2	+	3	351	c.240G>T	c.(238-240)CTG>CTT	p.L80L		NM_012228	NP_036360	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2 precursor	80					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0					L-Methionine(DB00134)	GGATCTACCTGAATAACAAGG	0.428													1	0	2.4624e-09	0.008871	2.8746e-09	20	22										T	23399191	G	T	23399191	2	4	29	1	0	0	0	0	0	0	0	1	9888	1277	45	3		3	MSRB2	10	23399191	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		23399191	112135556	82	8078										
GAD2	2572	broad.mit.edu	37	chr10	26559631	26559631	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtgtacggagcatttgacccCctcttagctgtcgctgacat	10	12	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:26559631C>A	uc001isp.2	+	10	1541	c.1038C>A	c.(1036-1038)CCC>CCA	p.P346P	GAD2_uc001isq.2_Silent_p.P346P	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	346					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CATTTGACCCCCTCTTAGCTG	0.488													1	0	2.65773e-34	0.00361	3.20136e-34	80	69										A	26559631	C	A	26559631	2	1	29	1	0	0	0	0	0	0	0	1	6180	610	22	4		4	GAD2	10	26559631	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	3160440	26559631	108975116	83	8079										
KIF5B	3799	broad.mit.edu	37	chr10	32311875	32311875	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tctaactgcttgcaacgtttCaccatggtttttacttctga	6	10	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:32311875C>T	uc001iwe.3	-	16	2285	c.1815G>A	c.(1813-1815)GTG>GTA	p.V605V		NM_004521	NP_004512	P33176	KINH_HUMAN	kinesin family member 5B	605					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(4)	lung(4)|ovary(1)	5		Prostate(175;0.0137)				TGCAACGTTTCACCATGGTTT	0.403													0	0	0	0.001523	0	22	31										T	32311875	C	T	32311875	2	4	29	1	0	0	0	0	0	0	0	1	8306	813	29	1		1	KIF5B	10	32311875	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	5752244	32311875	103222872	84	8080										
RTKN2	219790	broad.mit.edu	37	chr10	63978015	63978015	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aagctggctgggcaactagtCggcagcacatgttgccatac	12	11	0	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:63978015C>G	uc001jlw.2	-	8	924	c.827G>C	c.(826-828)CGA>CCA	p.R276P	RTKN2_uc009xpf.1_Missense_Mutation_p.R57P	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	276					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					GGCAACTAGTCGGCAGCACAT	0.368													0	0	0	0.002852	0	41	50										G	63978015	C	G	63978015	3	3	29	1	0	0	0	0	1	0	0	0	13723	884	31	1	1022	1	RTKN2	10	63978015	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	31666140	63978015	71556732	85	8081										
UNC5B	219699	broad.mit.edu	37	chr10	73053303	73053303	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gactggatctttcagctcaaGacccaggcccaccagggcca	10	15	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:73053303G>C	uc001jro.2	+	12	2359	c.1914G>C	c.(1912-1914)AAG>AAC	p.K638N	UNC5B_uc001jrp.2_Missense_Mutation_p.K627N	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	638	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						TTCAGCTCAAGACCCAGGCCC	0.637													0	0	0	0.003271	0	32	48										C	73053303	G	C	73053303	3	2	29	1	0	0	0	0	1	0	0	0	16989	933	33	1	1960	1	UNC5B	10	73053303	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	9075288	73053303	62481444	86	8082										
CDHR1	92211	broad.mit.edu	37	chr10	85973981	85973981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gccaccttctggcgcaacaaGaagtctaacaaggtcctgcc	9	14	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:85973981G>C	uc001kcv.2	+	17	2184	c.2184G>C	c.(2182-2184)AAG>AAC	p.K728N	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Missense_Mutation_p.K432N|CDHR1_uc001kcx.2_Missense_Mutation_p.K42N	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	728	Cytoplasmic (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						GGCGCAACAAGAAGTCTAACA	0.642													0	0	0	0.00361	0	42	35										C	85973981	G	C	85973981	3	2	29	1	0	0	0	0	1	0	0	0	3118	933	33	1	2250	1	CDHR1	10	85973981	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	12920678	85973981	49560766	87	8083										
NOC3L	64318	broad.mit.edu	37	chr10	96106204	96106204	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttctctgcattcttgatagaGattttctcttttctttgaaa	5	7	4	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:96106204G>C	uc001kjq.1	-	11	1455	c.1367C>G	c.(1366-1368)TCT>TGT	p.S456C	NOC3L_uc009xuk.1_Missense_Mutation_p.S241C	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	456	Potential.					nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				TCTTGATAGAGATTTTCTCTT	0.269													0	0	0	0.007413	0	18	41										C	96106204	G	C	96106204	3	2	29	1	0	0	0	0	1	0	0	0	10514	942	33	1	1079	1	NOC3L	10	96106204	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	10132223	96106204	39428543	88	8084										
CRTAC1	55118	broad.mit.edu	37	chr10	99664461	99664461	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cccatgggtgctcatttgcaGatagaggcggtgggggccat	16	9	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:99664461G>C	uc001kou.1	-	7	1317	c.961C>G	c.(961-963)CTG>GTG	p.L321V	CRTAC1_uc001kov.2_Missense_Mutation_p.L310V|CRTAC1_uc001kot.1_Missense_Mutation_p.L111V	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	321	FG-GAP 3; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CTCATTTGCAGATAGAGGCGG	0.473													0	0	0	0.00361	0	52	78										C	99664461	G	C	99664461	3	2	29	1	0	0	0	0	1	0	0	0	3896	933	33	1	1060	1	CRTAC1	10	99664461	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3558257	99664461	35870286	89	8085										
PPRC1	23082	broad.mit.edu	37	chr10	103897653	103897653	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttctggctttgtcagtctctCtcggctgggcccatctctga	10	13	5	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:103897653C>T	uc001kum.2	+	2	239	c.200C>T	c.(199-201)TCT>TTT	p.S67F	PPRC1_uc001kun.2_5'UTR|PPRC1_uc010qqj.1_Missense_Mutation_p.S67F|PPRC1_uc009xxa.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	67					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTCAGTCTCTCTCGGCTGGGC	0.562													0	0	0	0.001523	0	21	26										T	103897653	C	T	103897653	3	4	29	1	0	0	0	0	1	0	0	0	12410	913	32	1	206	1	PPRC1	10	103897653	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	4233192	103897653	31637094	90	8086										
PSD	5662	broad.mit.edu	37	chr10	104173719	104173719	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggggcgggagctggtgggtCgggccggggtgcagggggtt	26	6	0	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:104173719C>T	uc001kvg.1	-	5	1887	c.1360G>A	c.(1360-1362)GAC>AAC	p.D454N	PSD_uc001kvh.1_Missense_Mutation_p.D75N|PSD_uc009xxd.1_Missense_Mutation_p.D454N	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	454	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GCTGGTGGGTCGGGCCGGGGT	0.662													0	0	0	0.00361	0	47	32										T	104173719	C	T	104173719	3	4	29	1	0	0	0	0	1	0	0	0	12646	884	31	1	1766	1	PSD	10	104173719	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	276066	104173719	31361028	91	8087										
SIGIRR	59307	broad.mit.edu	37	chr11	407866	407866	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggtaccagagcagcacgttGagacggcacttgacatagag	13	9	0	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:407866G>C	uc001lpd.2	-	5	762	c.432C>G	c.(430-432)CTC>CTG	p.L144L	SIGIRR_uc001lpf.2_Silent_p.L144L|SIGIRR_uc001lpe.1_Silent_p.L144L|SIGIRR_uc001lpg.2_Silent_p.L144L	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	144	Cytoplasmic (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGCACGTTGAGACGGCACT	0.687													0	0	0	0.00361	0	55	3										C	407866	G	C	407866	2	2	29	1	0	0	0	0	0	0	0	1	14304	1277	45	1		1	SIGIRR	11	407866	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		407866	134598650	92	8088										
OR8J3	81168	broad.mit.edu	37	chr11	55905037	55905037	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acatggggttttgaagtcgaGagtcaacactggtgagggtg	16	5	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:55905037G>C	uc010riz.1	-	1	158	c.158C>G	c.(157-159)TCT>TGT	p.S53C		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TTGAAGTCGAGAGTCAACACT	0.473													0	0	0	0.00361	0	94	96										C	55905037	G	C	55905037	3	2	29	1	0	0	0	0	1	0	0	0	11242	942	33	1	791	1	OR8J3	11	55905037	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	55497171	55905037	79101479	93	8089										
SLC36A4	120103	broad.mit.edu	37	chr11	92916047	92916047	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	taattcctataaacacaaggCtgattggtccaagctgtggg	10	8	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:92916047C>G	uc001pdn.2	-	4	381	c.284G>C	c.(283-285)AGC>ACC	p.S95T	SLC36A4_uc001pdm.2_5'UTR	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	95	Helical; (Potential).				L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AAACACAAGGCTGATTGGTCC	0.328													0	0	0	0.00361	0	51	57										G	92916047	C	G	92916047	3	3	29	1	0	0	0	0	1	0	0	0	14596	797	28	4	1262	4	SLC36A4	11	92916047	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	37011010	92916047	42090469	94	8090										
EI24	9538	broad.mit.edu	37	chr11	125448904	125448904	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cctcacccattccctagtgtCagcaaaataattgctgacat	5	13	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:125448904C>T	uc001qca.2	+	7	743	c.501C>T	c.(499-501)GTC>GTT	p.V167V	EI24_uc001qcb.2_Silent_p.V167V|EI24_uc010sbd.1_RNA|EI24_uc009zbl.2_Silent_p.V167V|EI24_uc001qcc.2_RNA|EI24_uc010sbe.1_Silent_p.V153V|EI24_uc010sbf.1_RNA	NM_004879	NP_004870	O14681	EI24_HUMAN	etoposide induced 2.4 isoform 1	167					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TCCCTAGTGTCAGCAAAATAA	0.443													0	0	0	0.00308	0	5	1										T	125448904	C	T	125448904	2	4	29	1	0	0	0	0	0	0	0	1	4985	813	29	1		1	EI24	11	125448904	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	32532857	125448904	9557612	95	8091										
KCNJ5	3762	broad.mit.edu	37	chr11	128782060	128782060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aggctcagctgcatcaggaaGagtttgaagttgtggtcatt	13	6	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:128782060G>C	uc001qet.2	+	2	1206	c.892G>C	c.(892-894)GAG>CAG	p.E298Q	KCNJ5_uc009zck.2_Missense_Mutation_p.E298Q|KCNJ5_uc001qew.2_Missense_Mutation_p.E298Q	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	298	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GCATCAGGAAGAGTTTGAAGT	0.527													0	0	0	0.00361	0	49	4										C	128782060	G	C	128782060	3	2	29	1	0	0	0	0	1	0	0	0	8054	943	33	1	894	1	KCNJ5	11	128782060	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3333156	128782060	6224456	96	8092										
STYK1	55359	broad.mit.edu	37	chr12	10772796	10772796	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cactctgatgccggccacagCtgcatacagttcaggtacca	9	14	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:10772796C>T	uc001qys.2	-	11	1737	c.1216G>A	c.(1216-1218)GCT>ACT	p.A406T		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	406						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						CCGGCCACAGCTGCATACAGT	0.483										HNSCC(73;0.22)			0	0	0	0.00361	0	123	130										T	10772796	C	T	10772796	3	4	29	1	0	0	0	0	1	0	0	0	15358	797	28	2	56	2	STYK1	12	10772796	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		10772796	123079099	97	8093										
PDE3A	5139	broad.mit.edu	37	chr12	20774241	20774241	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tgcttttagtcctgattcttGgaataatccagtgatgatga	9	6	1	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:20774241G>A	uc001reh.1	+	5	1458	c.1436G>A	c.(1435-1437)TGG>TAG	p.W479*		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	479					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCTGATTCTTGGAATAATCCA	0.378													0	0	0	0.001368	0	13	19										A	20774241	G	A	20774241	4	1	29	1	0	0	0	0	0	1	0	0	11637	1357	47	2	1454	2	PDE3A	12	20774241	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	10001445	20774241	113077654	98	8094										
SOX5	6660	broad.mit.edu	37	chr12	23893927	23893927	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aggctggtcagctggttgatCatacccatgagttgcctttc	11	10	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:23893927C>G	uc001rfw.2	-	5	717	c.615G>C	c.(613-615)ATG>ATC	p.M205I	SOX5_uc001rfx.2_Missense_Mutation_p.M192I|SOX5_uc001rfy.2_Missense_Mutation_p.M192I|SOX5_uc010siv.1_Missense_Mutation_p.M192I|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.M157I	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	205	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GCTGGTTGATCATACCCATGA	0.438													0	0	0	0.001786	0	31	36										G	23893927	C	G	23893927	3	3	29	1	0	0	0	0	1	0	0	0	14954	826	29	1	1730	1	SOX5	12	23893927	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	3119686	23893927	109957968	99	8095										
TENC1	23371	broad.mit.edu	37	chr12	53454002	53454002	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggaggggacaggtacccattGcctgggcacctggcctcagc	15	13	1	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:53454002G>A	uc001sbp.2	+	18	2712	c.2577G>A	c.(2575-2577)TTG>TTA	p.L859L	TENC1_uc001sbl.2_Silent_p.L735L|TENC1_uc001sbn.2_Silent_p.L869L|TENC1_uc001sbq.2_Intron|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Silent_p.L354L|TENC1_uc001sbs.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	859	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						GGTACCCATTGCCTGGGCACC	0.637													0	0	0	0.004482	0	7	7										A	53454002	G	A	53454002	2	1	29	1	0	0	0	0	0	0	0	1	15755	1310	46	2		2	TENC1	12	53454002	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	29560075	53454002	80397893	100	8096										
ESYT1	23344	broad.mit.edu	37	chr12	56536837	56536837	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggacgtgatcctcctgatccCtatgtgtcactgttgctact	9	12	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:56536837C>G	uc001sjq.2	+	28	3074	c.3024C>G	c.(3022-3024)CCC>CCG	p.P1008P	ESYT1_uc001sjr.2_Silent_p.P1018P	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	1008	C2 5.					integral to membrane				ovary(4)|skin(1)	5						CTCCTGATCCCTATGTGTCAC	0.522													0	0	0	0.00361	0	75	85										G	56536837	C	G	56536837	2	3	29	1	0	0	0	0	0	0	0	1	5264	668	24	4		4	ESYT1	12	56536837	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	3082835	56536837	77315058	101	8097										
HCFC2	29915	broad.mit.edu	37	chr12	104476336	104476336	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aaaatactgagacttcacctCatgattgtgaatggagatgt	9	6	2	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:104476336C>T	uc001tkj.3	+	6	929	c.826C>T	c.(826-828)CAT>TAT	p.H276Y	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	276	Kelch 4.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						GACTTCACCTCATGATTGTGA	0.333													0	0	0	0.002299	0	21	38										T	104476336	C	T	104476336	3	4	29	1	0	0	0	0	1	0	0	0	6993	826	29	1	848	1	HCFC2	12	104476336	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	47939499	104476336	29375559	102	8098										
RNF10	9921	broad.mit.edu	37	chr12	121001667	121001667	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gaatgtgcgctgcctcgtgcGggagtacggcagcctggaga	17	10	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:121001667G>T	uc001typ.3	+	10	2069	c.1586G>T	c.(1585-1587)CGG>CTG	p.R529L	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.R440L	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	529					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCCTCGTGCGGGAGTACGGC	0.572													1	0	5.41795e-27	0.00361	6.49664e-27	78	111										T	121001667	G	T	121001667	3	4	29	1	0	0	0	0	1	0	0	0	13422	1116	39	4	1624	4	RNF10	12	121001667	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	16525331	121001667	12850228	103	8099										
NCOR2	9612	broad.mit.edu	37	chr12	124885065	124885065	+	Frame_Shift_Del	DEL	G	G	-													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acccagctcggcgctctgctGgggggtgatggcctcctcgc							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:124885065delG	uc010tba.1	-	15	1912	c.1795delC	c.(1795-1797)CAGfs	p.Q599fs	NCOR2_uc010tay.1_Frame_Shift_Del_p.Q599fs|NCOR2_uc010taz.1_Frame_Shift_Del_p.Q599fs|NCOR2_uc010tbb.1_Frame_Shift_Del_p.Q599fs|NCOR2_uc010tbc.1_Frame_Shift_Del_p.Q598fs|NCOR2_uc001ugj.1_Frame_Shift_Del_p.Q599fs	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	599					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGCTCTGCTGGGGGGTGATG	0.622																		65	92	---	---								-	124885065	G	-	124885065	7	5	29	1	0	1	0	1	0	0	0	0	10236	1357	47	0	5905	0	NCOR2	12	124885065	Frame_Shift_Del	DEL	G	TCGA-CF-A27C-01A-11D-A16O-08	3883398	124885065	8966830	104	8100										
TMEM132D	121256	broad.mit.edu	37	chr12	130185145	130185145	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gttggcctccttcaggaagaAggagacgtccgcgttgttga	14	9	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:130185145A>T	uc009zyl.1	-	2	506	c.178T>A	c.(178-180)TTC>ATC	p.F60I		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	60	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCAGGAAGAAGGAGACGTCC	0.552													0	0	0	0.006999	0	41	40										T	130185145	A	T	130185145	3	4	29	1	0	0	0	0	1	0	0	0	16044	72	3	5	3153	5	TMEM132D	12	130185145	Missense_Mutation	SNP	A	TCGA-CF-A27C-01A-11D-A16O-08	5300080	130185145	3666750	105	8101										
STOML3	161003	broad.mit.edu	37	chr13	39544479	39544479	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cagcactatagattctgtaaTagacaactccatctacctga	5	11	2	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:39544479T>A	uc001uwx.2	-	5	497	c.359A>T	c.(358-360)TAT>TTT	p.Y120F	STOML3_uc010tez.1_Missense_Mutation_p.Y111F	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	120	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GATTCTGTAATAGACAACTCC	0.433													0	0	0	0.00361	0	69	86										A	39544479	T	A	39544479	3	1	29	1	0	0	0	0	1	0	0	0	15314	1406	49	5	528	5	STOML3	13	39544479	Missense_Mutation	SNP	T	TCGA-CF-A27C-01A-11D-A16O-08		39544479	75625399	106	8102										
THSD1	55901	broad.mit.edu	37	chr13	52952521	52952521	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tgctgggcaaggcggtagctGaacagaggtgggattatctt	16	6	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:52952521G>A	uc001vgo.2	-	5	2129	c.1584C>T	c.(1582-1584)TTC>TTT	p.F528F	THSD1_uc001vgp.2_Silent_p.F475F|THSD1_uc010tgz.1_Silent_p.F149F|THSD1_uc010aea.2_5'UTR	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	528	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GGCGGTAGCTGAACAGAGGTG	0.552													0	0	0	0.001168	0	5	256										A	52952521	G	A	52952521	2	1	29	1	0	0	0	0	0	0	0	1	15874	1281	45	1		1	THSD1	13	52952521	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	13408042	52952521	62217357	107	8103										
RBM26	64062	broad.mit.edu	37	chr13	79916956	79916956	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttttgtttttctccagttttGaaattaacatctgccaaatt	4	7	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:79916956G>C	uc001vkz.2	-	17	2290	c.2276C>G	c.(2275-2277)TCA>TGA	p.S759*	RBM26_uc001vky.2_Nonsense_Mutation_p.S730*|RBM26_uc001vla.2_Nonsense_Mutation_p.S733*|RBM26_uc010tia.1_Nonsense_Mutation_p.S114*|RBM26_uc001vkx.2_Nonsense_Mutation_p.S469*	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	757	Potential.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CTCCAGTTTTGAAATTAACAT	0.244													0	0	0	0.00278	0	19	42										C	79916956	G	C	79916956	4	2	29	1	0	0	0	0	0	1	0	0	13126	1294	45	1	777	1	RBM26	13	79916956	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	26964435	79916956	35252922	108	8104										
PRMT5	10419	broad.mit.edu	37	chr14	23398498	23398498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccctagtgtgtcagctatttCggggacgcaattcaggtccc	11	12	2	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:23398498C>T	uc001whm.1	-	1	164	c.73G>A	c.(73-75)GAA>AAA	p.E25K	PRMT5_uc001whl.1_5'UTR|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_5'UTR|PRMT5_uc010tng.1_5'UTR|PRMT5_uc010tnh.1_Missense_Mutation_p.E25K|PRMT5_uc001whn.1_5'UTR	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	25					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TCAGCTATTTCGGGGACGCAA	0.682													0	0	0	0.007413	0	19	18										T	23398498	C	T	23398498	3	4	29	1	0	0	0	0	1	0	0	0	12539	893	31	1	1971	1	PRMT5	14	23398498	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		23398498	83951042	109	8105										
ACIN1	22985	broad.mit.edu	37	chr14	23533388	23533388	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	attacgctctgtctcatcctCagagatgcgagagtcatcag	9	11	5	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:23533388C>G	uc001wit.3	-	12	3023	c.2695G>C	c.(2695-2697)GAG>CAG	p.E899Q	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.E141Q|ACIN1_uc001wiq.3_Missense_Mutation_p.E141Q|ACIN1_uc001wir.3_Missense_Mutation_p.E172Q|ACIN1_uc001wis.3_Missense_Mutation_p.E580Q|ACIN1_uc010akg.2_Missense_Mutation_p.E886Q	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	899					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTCTCATCCTCAGAGATGCGA	0.567													0	0	0	0.002222	0	44	64										G	23533388	C	G	23533388	3	3	29	1	0	0	0	0	1	0	0	0	142	835	29	1	1362	1	ACIN1	14	23533388	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	134890	23533388	83816152	110	8106										
NIN	51199	broad.mit.edu	37	chr14	51259486	51259486	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cgcttcttcatccagtggctCaatcaccgtcacttcaggaa	7	14	6	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:51259486C>A	uc001wym.2	-	5	570	c.379G>T	c.(379-381)GAG>TAG	p.E127*	NIN_uc001wyi.2_Nonsense_Mutation_p.E127*|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Nonsense_Mutation_p.E127*|NIN_uc010tqp.1_Nonsense_Mutation_p.E133*|NIN_uc001wyo.2_Nonsense_Mutation_p.E127*|NIN_uc001wyp.1_Nonsense_Mutation_p.E89*	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	127					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TCCAGTGGCTCAATCACCGTC	0.547			T	PDGFRB	MPD								1	0	4.62619e-21	0.004289	5.49749e-21	35	50										A	51259486	C	A	51259486	4	1	29	1	0	0	0	0	0	1	0	0	10417	835	29	3	6278	3	NIN	14	51259486	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	27726098	51259486	56090054	111	8107										
FLVCR2	55640	broad.mit.edu	37	chr14	76045321	76045321	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gaggagactgtggcgatggtGaatgaaggtcccaaccagga	16	7	0	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:76045321G>A	uc001xrs.2	+	1	382	c.6G>A	c.(4-6)GTG>GTA	p.V2V		NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	2					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGGCGATGGTGAATGAAGGTC	0.597											OREG0022816	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001786	0	27	43										A	76045321	G	A	76045321	2	1	29	1	0	0	0	0	0	0	0	1	5946	1277	45	1		1	FLVCR2	14	76045321	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	24785835	76045321	31304219	112	8108										
TDP1	55775	broad.mit.edu	37	chr14	90455360	90455360	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aatcaaagtggttatgttctGagtttaaagagagcatgctg	11	4	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:90455360G>C	uc001xxy.2	+	11	1542	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.E415Q|TDP1_uc010atn.2_Missense_Mutation_p.E415Q|TDP1_uc001xya.2_Missense_Mutation_p.E176Q|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.E415Q|TDP1_uc001xyd.1_Missense_Mutation_p.E30Q	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	415					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		GTTATGTTCTGAGTTTAAAGA	0.493								Repair_of_DNA-protein_crosslinks					0	0	0	0.002445	0	32	39										C	90455360	G	C	90455360	3	2	29	1	0	0	0	0	1	0	0	0	15725	1291	45	1	1277	1	TDP1	14	90455360	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	14410039	90455360	16894180	113	8109										
MOAP1	64112	broad.mit.edu	37	chr14	93650050	93650050	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aaacatccagcgtccaaattCttcttctcctggttctggag	7	12	4	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:93650050C>T	uc001ybj.2	-	3	908	c.538G>A	c.(538-540)GAA>AAA	p.E180K	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	180				EEE->AAA: No effect on RASSF1-binding; interacts with BAX in the absence of RASSF1.	activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		cgtccaaattcttcttctcct	0													0	0	0	0.00361	0	49	47										T	93650050	C	T	93650050	3	4	29	1	0	0	0	0	1	0	0	0	9680	922	32	1	521	1	MOAP1	14	93650050	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	3194690	93650050	13699490	114	8110										
OR4N4	283694	broad.mit.edu	37	chr15	22382961	22382961	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	attatccaggtggtcctcatCctccgcttgcctttttgtgg	9	12	1	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:22382961C>T	uc001yuc.1	+	7	1470	c.489C>T	c.(487-489)ATC>ATT	p.I163I	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Silent_p.I163I	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGGTCCTCATCCTCCGCTTGC	0.522													0	0	0	0.00361	0	55	235										T	22382961	C	T	22382961	2	4	29	1	0	0	0	0	0	0	0	1	11078	845	30	1		1	OR4N4	15	22382961	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		22382961	80148431	115	8111										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32928484	32928484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aaaagatcagtaagtctgagGaaaccttactaactccagag	8	8	2	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:32928484G>A	uc001zgy.1	+	12	2232	c.1510G>A	c.(1510-1512)GAA>AAA	p.E504K	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.E315K|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.E315K	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	504					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TAAGTCTGAGGAAACCTTACT	0.368													0	0	0	0.002096	0	30	26										A	32928484	G	A	32928484	3	1	29	1	0	0	0	0	1	0	0	0	863	1175	41	1	1579	1	ARHGAP11A	15	32928484	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	10545523	32928484	69602908	116	8112										
CATSPER2	117155	broad.mit.edu	37	chr15	43939559	43939559	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cagcgcacatgaagcctgctCaacagcctctgggcatgtga	11	13	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:43939559C>T	uc001zsh.2	-	3	467	c.252G>A	c.(250-252)TTG>TTA	p.L84L	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.L84L|CATSPER2_uc001zsj.2_Silent_p.L84L|CATSPER2_uc001zsk.2_Silent_p.L84L|CATSPER2_uc001zsl.1_RNA	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	84	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GAAGCCTGCTCAACAGCCTCT	0.498													0	0	0	0.00623	0	38	151										T	43939559	C	T	43939559	2	4	29	1	0	0	0	0	0	0	0	1	2688	825	29	1		1	CATSPER2	15	43939559	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	11011075	43939559	58591833	117	8113										
SPG11	80208	broad.mit.edu	37	chr15	44876629	44876629	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gggcctgggttgagaaaaagGaagaagctgctttgcttgaa	15	5	0	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:44876629G>C	uc001ztx.2	-	30	5280	c.5249C>G	c.(5248-5250)TCC>TGC	p.S1750C	SPG11_uc010bdw.2_Missense_Mutation_p.S39C|SPG11_uc010ueh.1_Missense_Mutation_p.S1750C|SPG11_uc010uei.1_Missense_Mutation_p.S1750C|SPG11_uc001zty.1_Missense_Mutation_p.S479C	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1750	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGAGAAAAAGGAAGAAGCTGC	0.463													0	0	0	0.002445	0	34	38										C	44876629	G	C	44876629	3	2	29	1	0	0	0	0	1	0	0	0	15040	1174	41	1	2126	1	SPG11	15	44876629	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	937070	44876629	57654763	118	8114										
TNFAIP8L3	388121	broad.mit.edu	37	chr15	51397222	51397222	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	caagtccctttcccctctgaAgatgaaaagataaggggatg	10	9	1	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:51397222A>G	uc001zyy.2	-	1	252	c.152T>C	c.(151-153)CTT>CCT	p.L51P		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	51											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		TCCCCTCTGAAGATGAAAAGA	0.542													0	0	0	0.003954	0	14	110										G	51397222	A	G	51397222	3	3	29	1	0	0	0	0	1	0	0	0	16276	72	3	5	738	5	TNFAIP8L3	15	51397222	Missense_Mutation	SNP	A	TCGA-CF-A27C-01A-11D-A16O-08	6520593	51397222	51134170	119	8115										
TNFAIP8L3	388121	broad.mit.edu	37	chr15	51397239	51397240	+	Missense_Mutation	DNP	GA	GA	AT													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tgaagatgaaaagataagggGatgagtcttgtttgtaacgt							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:51397239_51397240GA>AT	uc001zyy.2	-	1	234_235	c.134_135TC>AT	c.(133-135)ATC>AAT	p.I45N		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	45											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AAGATAAGGGGATGAGTCTTGT	0.535													0	0	0	0.004672	0	14	104										AT	51397240	GA	AT	51397239	3	1	29	1	0	0	0	0	1	0	0	0	16276	1164	41	1	755	1	TNFAIP8L3	15	51397239	Missense_Mutation	DNP	GA	TCGA-CF-A27C-01A-11D-A16O-08	17	51397239	51134153	120	8116										
ADAM10	102	broad.mit.edu	37	chr15	58932978	58932978	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tttaatatgataaactacctGaaggtgctccaacccaagcc	6	11	0	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:58932978G>A	uc002afd.1	-	8	1454	c.1010C>T	c.(1009-1011)TCA>TTA	p.S337L	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.S36L|ADAM10_uc002afe.1_RNA	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	337	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		TAAACTACCTGAAGGTGCTCC	0.388													0	0	0	0.001855	0	12	16										A	58932978	G	A	58932978	3	1	29	1	0	0	0	0	1	0	0	0	234	1294	45	1	1272	1	ADAM10	15	58932978	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	7535739	58932978	43598414	121	8117										
FAM63B	54629	broad.mit.edu	37	chr15	59139599	59139599	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tgatggaaatttctgtgactCagaatttcatcttcgacctc	7	9	4	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:59139599C>T	uc002afj.2	+	7	1674	c.1472C>T	c.(1471-1473)TCA>TTA	p.S491L	FAM63B_uc002afi.2_Missense_Mutation_p.S491L|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	491										central_nervous_system(1)	1						TTCTGTGACTCAGAATTTCAT	0.393													0	0	0	0.003271	0	37	30										T	59139599	C	T	59139599	3	4	29	1	0	0	0	0	1	0	0	0	5597	838	29	1	1498	1	FAM63B	15	59139599	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	206621	59139599	43391793	122	8118										
HERC1	8925	broad.mit.edu	37	chr15	63986695	63986695	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	caaagaaacatctactggttGataatgaacacttagggcaa	8	7	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:63986695G>A	uc002amp.2	-	29	5444	c.5296C>T	c.(5296-5298)CAA>TAA	p.Q1766*		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1766					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCTACTGGTTGATAATGAACA	0.423													0	0	0	0.002836	0	32	31										A	63986695	G	A	63986695	4	1	29	1	0	0	0	0	0	1	0	0	7057	1299	45	1	9489	1	HERC1	15	63986695	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	4847096	63986695	38544697	123	8119										
SCAPER	49855	broad.mit.edu	37	chr15	76763592	76763592	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aggtccattaagaaggtaatCttgttactaaacagaacatc	7	7	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:76763592C>G	uc002bby.2	-	24	3098	c.3039G>C	c.(3037-3039)AAG>AAC	p.K1013N	SCAPER_uc010bkr.2_Missense_Mutation_p.K321N|SCAPER_uc002bbx.2_Missense_Mutation_p.K767N|SCAPER_uc002bbz.1_Missense_Mutation_p.K884N	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1012						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AGAAGGTAATCTTGTTACTAA	0.378													0	0	0	0.007291	0	27	40										G	76763592	C	G	76763592	3	3	29	1	0	0	0	0	1	0	0	0	13878	912	32	1	1195	1	SCAPER	15	76763592	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	12776897	76763592	25767800	124	8120										
PKMYT1	9088	broad.mit.edu	37	chr16	3025757	3025757	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gcccggtccttggggccccgGaatggtgacatggaacgctt	15	12	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:3025757G>A	uc002csn.2	-	4	878	c.435C>T	c.(433-435)TTC>TTT	p.F145F	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.F145F|PKMYT1_uc002cso.2_Silent_p.F76F|PKMYT1_uc002csp.2_Silent_p.F136F|PKMYT1_uc002csq.2_Silent_p.F136F|PKMYT1_uc010bsy.1_Silent_p.F136F	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	145	Protein kinase.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						TGGGGCCCCGGAATGGTGACA	0.677													0	0	0	0.002445	0	33	24										A	3025757	G	A	3025757	2	1	29	1	0	0	0	0	0	0	0	1	11978	1165	41	1		1	PKMYT1	16	3025757	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		3025757	87328996	125	8121										
PKMYT1	9088	broad.mit.edu	37	chr16	3026840	3026840	+	Missense_Mutation	SNP	G	G	T													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gccagcctggggtccgaggaGggaagaggcggctgatggga							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:3026840G>T	uc002csn.2	-	3	646	c.203C>A	c.(202-204)CCT>CAT	p.P68H	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Missense_Mutation_p.P68H|PKMYT1_uc002cso.2_Intron|PKMYT1_uc002csp.2_Missense_Mutation_p.P59H|PKMYT1_uc002csq.2_Missense_Mutation_p.P59H|PKMYT1_uc010bsy.1_Missense_Mutation_p.P59H	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	68	Pro-rich.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						GGTCCGAGGAGGGAAGAGGCG	0.692													1	0	0.000602214	0.000602	0.000693856	5	4										T	3026840	G	T	3026840	3	4	29	1	0	0	0	0	1	0	0	0	11978	1000	35	4	1362	4	PKMYT1	16	3026840	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	1083	3026840	87327913	126	8122	36	2								
PKMYT1	9088	broad.mit.edu	37	chr16	3026845	3026845	+	Silent	SNP	G	G	A													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cctggggtccgaggagggaaGaggcggctgatgggaatgct							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:3026845G>A	uc002csn.2	-	3	641	c.198C>T	c.(196-198)CTC>CTT	p.L66L	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.L66L|PKMYT1_uc002cso.2_Intron|PKMYT1_uc002csp.2_Silent_p.L57L|PKMYT1_uc002csq.2_Silent_p.L57L|PKMYT1_uc010bsy.1_Silent_p.L57L	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	66	Pro-rich.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						GAGGAGGGAAGAGGCGGCTGA	0.687													0	0	0	0.000248	0	4	4										A	3026845	G	A	3026845	2	1	29	1	0	0	0	0	0	0	0	1	11978	929	33	1		1	PKMYT1	16	3026845	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	5	3026845	87327908	127	8123	36	2								
BFAR	51283	broad.mit.edu	37	chr16	14749055	14749055	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtgaagcccccccagaatctCtgggaatataaggtgaacac	10	11	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:14749055C>T	uc002dco.2	+	5	1052	c.771C>T	c.(769-771)CTC>CTT	p.L257L	BFAR_uc002dcp.2_Silent_p.L132L|BFAR_uc010uzh.1_Silent_p.L129L	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	257	Lumenal (Potential).				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						CCCAGAATCTCTGGGAATATA	0.328													0	0	0	0.002222	0	46	53										T	14749055	C	T	14749055	2	4	29	1	0	0	0	0	0	0	0	1	1414	900	32	1		1	BFAR	16	14749055	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	11722210	14749055	75605698	128	8124										
QPRT	23475	broad.mit.edu	37	chr16	29706228	29706228	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gaagctggtgccggtggccaGagtggccgaggtccggggcc	20	11	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:29706228G>A	uc002dto.2	+	2	335	c.257G>A	c.(256-258)AGA>AAA	p.R86K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|QPRT_uc010vdu.1_Intron	NM_014298	NP_055113	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	86					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity				0					Niacin(DB00627)	CCGGTGGCCAGAGTGGCCGAG	0.657													0	0	0	0.002222	0	40	37										A	29706228	G	A	29706228	3	1	29	1	0	0	0	0	1	0	0	0	12876	942	33	1	263	1	QPRT	16	29706228	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	14957173	29706228	60648525	129	8125										
ITFG1	81533	broad.mit.edu	37	chr16	47195718	47195719	+	Frame_Shift_Ins	INS	-	-	CAGTC													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctgggaatttggaatgattgINScagtccactcttgttttcgt							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:47195718_47195719insCAGTC	uc002eet.2	-	16	1665_1666	c.1603_1604insGACTG	c.(1603-1605)GCAfs	p.A535fs	ITFG1_uc010vgg.1_Frame_Shift_Ins_p.A280fs|ITFG1_uc010vgh.1_Frame_Shift_Ins_p.A422fs	NM_030790	NP_110417	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	535						extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				TGGAATGATTGCAGTCCACTCT	0.337																		7	109	---	---								CAGTC	47195719	-	CAGTC	47195718	7	5	29	1	0	1	1	0	0	0	0	0	7869	1319	46	0	246	0	ITFG1	16	47195718	Frame_Shift_Ins	INS	-	TCGA-CF-A27C-01A-11D-A16O-08	17489490	47195718	43159035	130	8126										
CETP	1071	broad.mit.edu	37	chr16	57005235	57005235	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctgctctgtctgccccagatCtgcaaagagatcaacgtcat	8	13	5	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:57005235C>G	uc002eki.2	+	7	657	c.600C>G	c.(598-600)ATC>ATG	p.I200M	CETP_uc002ekj.2_Missense_Mutation_p.I200M	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	200					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						TGCCCCAGATCTGCAAAGAGA	0.577													0	0	0	0.00361	0	116	137										G	57005235	C	G	57005235	3	3	29	1	0	0	0	0	1	0	0	0	3277	903	32	1	626	1	CETP	16	57005235	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	9809517	57005235	33349518	131	8127										
NLRC5	84166	broad.mit.edu	37	chr16	57092020	57092020	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acagcggactcagatgccttCtggaatgtctgccgcaggtg	13	11	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:57092020C>G	uc002ekk.1	+	28	4015	c.3790C>G	c.(3790-3792)CTG>GTG	p.L1264V	NLRC5_uc002ekn.2_Intron|NLRC5_uc002ekl.2_Missense_Mutation_p.L1068V|NLRC5_uc002ekm.2_Missense_Mutation_p.L1038V|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Missense_Mutation_p.L179V|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Missense_Mutation_p.L151V	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1264	LRR 13.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CAGATGCCTTCTGGAATGTCT	0.572													0	0	0	0.000978	0	10	12										G	57092020	C	G	57092020	3	3	29	1	0	0	0	0	1	0	0	0	10470	912	32	1	3892	1	NLRC5	16	57092020	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	86785	57092020	33262733	132	8128										
CMTM1	113540	broad.mit.edu	37	chr16	66603973	66603973	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctaacccttcaccacttgctGacctatttacattggccctt	4	15	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:66603973G>A	uc002epi.3	+	2	339	c.216G>A	c.(214-216)CTG>CTA	p.L72L	CMTM1_uc002epb.3_RNA|CMTM1_uc002epc.3_RNA|CMTM1_uc002epd.3_Intron|CMTM1_uc002epe.3_Intron|CMTM1_uc002epf.3_Intron|CMTM1_uc002epg.3_Intron|CMTM1_uc002eph.3_Silent_p.L72L|CMTM1_uc002epl.3_Intron|CMTM1_uc002epj.3_Intron|CMTM1_uc002epk.3_Intron|CMTM1_uc002epa.3_Intron|CMTM1_uc002epn.3_Silent_p.L189L|CMTM1_uc002epo.3_RNA|CMTM1_uc002epp.3_RNA|CMTM1_uc002epq.3_RNA|CMTM1_uc010cds.2_RNA|CMTM1_uc002epr.3_Silent_p.L189L|CMTM1_uc002epm.3_RNA|CMTM1_uc002eps.2_RNA	NM_181269	NP_851786	Q8IZ96	CKLF1_HUMAN	chemokine-like factor superfamily 1 isoform 1	72	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		ACCACTTGCTGACCTATTTAC	0.388													0	0	0	0.00361	0	76	101										A	66603973	G	A	66603973	2	1	29	1	0	0	0	0	0	0	0	1	3582	1277	45	1		1	CMTM1	16	66603973	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	9511953	66603973	23750780	133	8129										
MTSS1L	92154	broad.mit.edu	37	chr16	70713737	70713737	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggccgccttcttccagtcctCgatgcgctcctgcagcgggt	12	16	1	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:70713737C>G	uc002ezj.2	-	5	594	c.334G>C	c.(334-336)GAG>CAG	p.E112Q	MTSS1L_uc002ezk.1_Missense_Mutation_p.E32Q	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	112	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						TTCCAGTCCTCGATGCGCTCC	0.602													0	0	0	0.003163	0	14	10										G	70713737	C	G	70713737	3	3	29	1	0	0	0	0	1	0	0	0	9963	893	31	1	1953	1	MTSS1L	16	70713737	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	4109764	70713737	19641016	134	8130										
ZFHX3	463	broad.mit.edu	37	chr16	72821414	72821414	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tttgagtgagcggcagactgCgaggtagatgcggtgctagg	18	6	0	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:72821414C>T	uc002fck.2	-	10	11434	c.10761G>A	c.(10759-10761)TCG>TCA	p.S3587S	uc002fcj.1_Intron|ZFHX3_uc002fcl.2_Silent_p.S2673S	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3587					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CGGCAGACTGCGAGGTAGATG	0.617													0	0	0	0.00361	0	64	85										T	72821414	C	T	72821414	2	4	29	1	0	0	0	0	0	0	0	1	17631	755	27	2		2	ZFHX3	16	72821414	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2107677	72821414	17533339	135	8131										
CHST6	4166	broad.mit.edu	37	chr16	75512780	75512780	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acgaagtcttgaaggcttcgCggcgcgcaccaggtccagat	13	12	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:75512780C>T	uc002fef.2	-	3	1127	c.947G>A	c.(946-948)CGC>CAC	p.R316H	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R316H	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	316	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GAAGGCTTCGCGGCGCGCACC	0.627													0	0	0	0.005524	0	40	46										T	75512780	C	T	75512780	3	4	29	1	0	0	0	0	1	0	0	0	3408	768	27	2	244	2	CHST6	16	75512780	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2691366	75512780	14841973	136	8132										
ZCCHC14	23174	broad.mit.edu	37	chr16	87446453	87446453	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggggcagggggtggtggcctGatggattggagctggcctca	21	7	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:87446453G>C	uc002fjz.1	-	12	1490	c.1463C>G	c.(1462-1464)TCA>TGA	p.S488*	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Nonsense_Mutation_p.S264*	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	488					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GTGGTGGCCTGATGGATTGGA	0.612													0	0	0	0.001786	0	33	40										C	87446453	G	C	87446453	4	2	29	1	0	0	0	0	0	1	0	0	17580	1294	45	1	1394	1	ZCCHC14	16	87446453	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	11933673	87446453	2908300	137	8133										
DPEP1	1800	broad.mit.edu	37	chr16	89703951	89703951	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccaacaaggccaacctgtccCaagtggccggtaggtggggt	14	12	0	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:89703951C>T	uc010cin.2	+	8	1047	c.844C>T	c.(844-846)CAA>TAA	p.Q282*	DPEP1_uc002fnr.3_Nonsense_Mutation_p.Q282*|DPEP1_uc002fns.3_Nonsense_Mutation_p.Q282*	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	282					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CAACCTGTCCCAAGTGGCCGG	0.577													0	0	0	0.00361	0	77	65										T	89703951	C	T	89703951	4	4	29	1	0	0	0	0	0	1	0	0	4713	595	21	2	870	2	DPEP1	16	89703951	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2257498	89703951	650802	138	8134										
SLC43A2	124935	broad.mit.edu	37	chr17	1478943	1478943	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gagccgttgattttgaggaaGagtttgtcatcctcctgcct	11	9	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:1478943G>C	uc002fsv.2	-	14	1754	c.1665C>G	c.(1663-1665)CTC>CTG	p.L555L	SLC43A2_uc002fsu.2_Silent_p.L559L	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	555					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TTTTGAGGAAGAGTTTGTCAT	0.617													0	0	0	0.003163	0	10	1										C	1478943	G	C	1478943	2	2	29	1	0	0	0	0	0	0	0	1	14633	929	33	1		1	SLC43A2	17	1478943	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		1478943	79716267	139	8135										
ITGAE	3682	broad.mit.edu	37	chr17	3649140	3649140	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tcaggcagcccagacagcttCttacgtctgaacactgcagc	9	14	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:3649140C>G	uc002fwo.3	-	18	2336	c.2237G>C	c.(2236-2238)AGA>ACA	p.R746T		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	746	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CAGACAGCTTCTTACGTCTGA	0.587													0	0	0	0.00361	0	49	6										G	3649140	C	G	3649140	3	3	29	1	0	0	0	0	1	0	0	0	7885	913	32	1	1358	1	ITGAE	17	3649140	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2170197	3649140	77546070	140	8136										
ANKFY1	51479	broad.mit.edu	37	chr17	4080443	4080443	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aattgcggacaataatttctGagcctgcttggacagcgagg	12	8	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:4080443G>C	uc002fxq.1	-	19	2791	c.2753C>G	c.(2752-2754)TCA>TGA	p.S918*	ANKFY1_uc002fxn.2_Nonsense_Mutation_p.S960*|ANKFY1_uc002fxo.2_Nonsense_Mutation_p.S919*|ANKFY1_uc002fxp.2_Nonsense_Mutation_p.S917*|ANKFY1_uc010ckp.2_Nonsense_Mutation_p.S860*	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	918	ANK 17.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						AATAATTTCTGAGCCTGCTTG	0.448													0	0	0	0.00361	0	45	1										C	4080443	G	C	4080443	4	2	29	1	0	0	0	0	0	1	0	0	626	1294	45	1	784	1	ANKFY1	17	4080443	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	431303	4080443	77114767	141	8137										
GPS2	2874	broad.mit.edu	37	chr17	7216947	7216947	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cccatagtgaggtgggggctGagcagtcccataggcaccac	14	12	0	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:7216947G>A	uc002gfv.1	-	6	837	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	GPS2_uc002gfw.1_Nonsense_Mutation_p.Q154*|GPS2_uc002gfx.1_Nonsense_Mutation_p.Q192*|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Nonsense_Mutation_p.Q192*	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	192					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				GGTGGGGGCTGAGCAGTCCCA	0.577											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	64	5										A	7216947	G	A	7216947	4	1	29	1	0	0	0	0	0	1	0	0	6733	1299	45	1	429	1	GPS2	17	7216947	Nonsense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3136504	7216947	73978263	142	8138										
ALOX12B	242	broad.mit.edu	37	chr17	7976526	7976526	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agcgtgatgcacgtggtcttCacatccggcaacgtgtccat	11	12	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:7976526C>T	uc002gjy.1	-	14	2127	c.1866G>A	c.(1864-1866)GTG>GTA	p.V622V		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	622	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						ACGTGGTCTTCACATCCGGCA	0.622										Multiple Myeloma(8;0.094)			0	0	0	0.000248	0	4	119										T	7976526	C	T	7976526	2	4	29	1	0	0	0	0	0	0	0	1	537	813	29	1		1	ALOX12B	17	7976526	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	759579	7976526	73218684	143	8139										
DNAH9	1770	broad.mit.edu	37	chr17	11572854	11572854	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggtcagtttctgctgtacggGcacatcctcactccggaaga	11	12	3	1	rs36016893		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:11572854G>A	uc002gne.2	+	17	3164	c.3096G>A	c.(3094-3096)GGG>GGA	p.G1032G	DNAH9_uc010coo.2_Silent_p.G326G	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1032	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCTGTACGGGCACATCCTCA	0.517													0	0	0	0.001168	0	4	91										A	11572854	G	A	11572854	2	1	29	1	0	0	0	0	0	0	0	1	4608	1190	42	2		2	DNAH9	17	11572854	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3596328	11572854	69622356	144	8140										
CPD	1362	broad.mit.edu	37	chr17	28791803	28791803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aggatgaaacagacactgaaGaggaaacattatattctagc	9	6	1	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:28791803G>C	uc002hfb.1	+	21	4129	c.4114G>C	c.(4114-4116)GAG>CAG	p.E1372Q	CPD_uc010wbo.1_Missense_Mutation_p.E1125Q|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1372	Cytoplasmic (Potential).				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AGACACTGAAGAGGAAACATT	0.413													0	0	0	0.00361	0	57	75										C	28791803	G	C	28791803	3	2	29	1	0	0	0	0	1	0	0	0	3798	943	33	1	4196	1	CPD	17	28791803	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	17218949	28791803	52403407	145	8141										
ATP6V0A1	535	broad.mit.edu	37	chr17	40618453	40618453	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tttttatttttcagttaaatCcagatgtgaatgttttccaa	5	5	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:40618453C>G	uc002hzr.2	+	3	291	c.124C>G	c.(124-126)CCA>GCA	p.P42A	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.P42A|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.P42A|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.P42A|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.P42A|ATP6V0A1_uc010cyg.2_Intron|ATP6V0A1_uc002hzp.1_Missense_Mutation_p.P42A	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	42	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TCAGTTAAATCCAGATGTGAA	0.318													0	0	0	0.005443	0	26	24										G	40618453	C	G	40618453	3	3	29	1	0	0	0	0	1	0	0	0	1168	855	30	1	130	1	ATP6V0A1	17	40618453	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	11826650	40618453	40576757	146	8142										
TLK2	11011	broad.mit.edu	37	chr17	60598163	60598163	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aatagtgagtcttccaaccaGagcttgtgcagcgtcggatc	11	10	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:60598163G>C	uc010ddp.2	+	3	379	c.111G>C	c.(109-111)CAG>CAC	p.Q37H	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Missense_Mutation_p.Q37H|TLK2_uc002jaa.3_Missense_Mutation_p.Q37H|TLK2_uc010wpd.1_Missense_Mutation_p.Q37H	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	37					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						CTTCCAACCAGAGCTTGTGCA	0.343													0	0	0	0.00361	0	47	110										C	60598163	G	C	60598163	3	2	29	1	0	0	0	0	1	0	0	0	15941	933	33	1	117	1	TLK2	17	60598163	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	19979710	60598163	20597047	147	8143										
CSH1	1442	broad.mit.edu	37	chr17	61972839	61972839	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggcgccaccctcacccccatCagcgtttggatgccttcctc	8	19	2	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:61972839C>T	uc002jcs.1	-	4	566	c.450G>A	c.(448-450)CTG>CTA	p.L150L	CSH2_uc002jck.2_Intron|CSH1_uc002jcp.1_Silent_p.L111L|CSH1_uc002jcq.1_Silent_p.L111L|CSH1_uc002jcr.1_3'UTR|CSH1_uc002jct.1_Silent_p.L116L|CSH1_uc002jcu.1_Silent_p.L150L|CSH1_uc002jcv.1_Intron|CSH1_uc002jcw.2_Silent_p.L150L|CSH1_uc002jcy.2_3'UTR	NM_001317	NP_001308	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 isoform 1	150					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			skin(1)	1						TCACCCCCATCAGCGTTTGGA	0.562									Russell-Silver_syndrome				0	0	0	0.00361	0	45	91										T	61972839	C	T	61972839	2	4	29	1	0	0	0	0	0	0	0	1	3940	813	29	1		1	CSH1	17	61972839	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	1374676	61972839	19222371	148	8144										
HELZ	9931	broad.mit.edu	37	chr17	65175038	65175038	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tttgcatgcatcaggtattcGagatctaaatggaaacaaaa	8	6	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:65175038G>A	uc010wqk.1	-	13	1354	c.1167C>T	c.(1165-1167)CTC>CTT	p.L389L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.L389L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCAGGTATTCGAGATCTAAAT	0.259													0	0	0	0.004289	0	37	62										A	65175038	G	A	65175038	2	1	29	1	0	0	0	0	0	0	0	1	7049	1045	37	1		1	HELZ	17	65175038	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	3202199	65175038	16020172	149	8145										
TRIM65	201292	broad.mit.edu	37	chr17	73892977	73892977	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tcctggtagagccccaggcaGatggcgcaggtcagcttctc	13	13	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:73892977G>A	uc002jpx.2	-	1	78	c.42C>T	c.(40-42)ATC>ATT	p.I14I		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	14	RING-type.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCCCAGGCAGATGGCGCAGG	0.726													0	0	0	0.001168	0	5	8										A	73892977	G	A	73892977	2	1	29	1	0	0	0	0	0	0	0	1	16536	932	33	1		1	TRIM65	17	73892977	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	8717939	73892977	7302233	150	8146										
MIB1	57534	broad.mit.edu	37	chr18	19345737	19345737	+	Silent	SNP	C	C	T													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtccttgttttaataggcatCaagcatgatggaaccatgtg							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr18:19345737C>T	uc002ktq.2	+	2	234	c.234C>T	c.(232-234)ATC>ATT	p.I78I	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	78					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			TAATAGGCATCAAGCATGATG	0.363													0	0	0	0.001786	0	29	38										T	19345737	C	T	19345737	2	4	29	1	0	0	0	0	0	0	0	1	9566	816	29	1		1	MIB1	18	19345737	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08		19345737	58731511	151	8147	37	2								
MIB1	57534	broad.mit.edu	37	chr18	19345741	19345741	+	Missense_Mutation	SNP	C	C	G													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttgttttaataggcatcaagCatgatggaaccatgtgtgat							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr18:19345741C>G	uc002ktq.2	+	2	238	c.238C>G	c.(238-240)CAT>GAT	p.H80D	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	80	ZZ-type.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			AGGCATCAAGCATGATGGAAC	0.363													0	0	0	0.003271	0	32	39										G	19345741	C	G	19345741	3	3	29	1	0	0	0	0	1	0	0	0	9566	710	25	4	244	4	MIB1	18	19345741	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	4	19345741	58731507	152	8148	37	2								
IMPACT	55364	broad.mit.edu	37	chr18	22025392	22025392	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tccaaattgtatgagaataaGaaaatagctagtgccaccca	7	8	0	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr18:22025392G>C	uc002kvh.3	+	8	742	c.630G>C	c.(628-630)AAG>AAC	p.K210N	IMPACT_uc002kvg.3_Missense_Mutation_p.K192N	NM_018439	NP_060909	Q9P2X3	IMPCT_HUMAN	Impact homolog	210											0	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					ATGAGAATAAGAAAATAGCTA	0.308													0	0	0	0.002836	0	30	47										C	22025392	G	C	22025392	3	2	29	1	0	0	0	0	1	0	0	0	7724	933	33	1	660	1	IMPACT	18	22025392	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	2679651	22025392	56051856	153	8149										
BSG	682	broad.mit.edu	37	chr19	580761	580761	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	actgactgggcctggtacaaGatcactgactctgaggacaa	11	10	2	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:580761G>C	uc002loz.2	+	5	869	c.771G>C	c.(769-771)AAG>AAC	p.K257N	BSG_uc002loy.2_Missense_Mutation_p.K77N|BSG_uc002lpa.2_Missense_Mutation_p.K141N|BSG_uc002lpb.2_RNA|BSG_uc010drr.2_Missense_Mutation_p.K141N|BSG_uc002lpc.2_Missense_Mutation_p.K304N|BSG_uc002lpd.2_5'Flank	NM_001728	NP_001719	P35613	BASI_HUMAN	basigin isoform 1 precursor	257	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGTACAAGATCACTGACT	0.612													0	0	0	0.007413	0	19	38										C	580761	G	C	580761	3	2	29	1	0	0	0	0	1	0	0	0	1529	933	33	1	825	1	BSG	19	580761	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		580761	58548222	154	8150										
MEX3D	399664	broad.mit.edu	37	chr19	1556090	1556090	+	Frame_Shift_Del	DEL	A	A	-													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggcaagggggcggcgcgctcAaaaggcgcccagatggtggc							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:1556090delA	uc010dsn.2	-	2	1428	c.1428delT	c.(1426-1428)TTTfs	p.F476fs		NM_203304	NP_976049	Q86XN8	MEX3D_HUMAN	ring finger and KH domain containing 1	476					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCGCGCTCAAAAGGCGCCC	0.652																		2	4	---	---								-	1556090	A	-	1556090	7	5	29	1	0	1	0	1	0	0	0	0	9512	127	5	0	594	0	MEX3D	19	1556090	Frame_Shift_Del	DEL	A	TCGA-CF-A27C-01A-11D-A16O-08	975329	1556090	57572893	155	8151										
MUC16	94025	broad.mit.edu	37	chr19	9089752	9089752	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggttccttccctgaaagctGaggactgtagagatgatgtc	12	8	0	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:9089752G>A	uc002mkp.2	-	1	2267	c.2063C>T	c.(2062-2064)TCA>TTA	p.S688L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	688	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGAAAGCTGAGGACTGTAG	0.507													0	0	0	0.00361	0	58	50										A	9089752	G	A	9089752	3	1	29	1	0	0	0	0	1	0	0	0	9973	1294	45	1	41796	1	MUC16	19	9089752	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	7533662	9089752	50039231	156	8152										
KRI1	65095	broad.mit.edu	37	chr19	10668240	10668240	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gcccctacctcctcagtgctGaggccaaagtcacagggcac	10	16	2	1	rs144674130	by1000genomes	TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:10668240G>A	uc002moy.1	-	16	1632	c.1623C>T	c.(1621-1623)CTC>CTT	p.L541L	KRI1_uc002mow.1_Silent_p.L160L|KRI1_uc002mox.1_Silent_p.L537L	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	541										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCTCAGTGCTGAGGCCAAAGT	0.602													0	0	0	0.002299	0	23	25										A	10668240	G	A	10668240	2	1	29	1	0	0	0	0	0	0	0	1	8444	1277	45	1		1	KRI1	19	10668240	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	1578488	10668240	48460743	157	8153										
KRI1	65095	broad.mit.edu	37	chr19	10668297	10668297	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aagcgacagggcaggtcgtcGatgatgtcctcgtagtccag	14	10	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:10668297G>A	uc002moy.1	-	16	1575	c.1566C>T	c.(1564-1566)ATC>ATT	p.I522I	KRI1_uc002mow.1_Silent_p.I141I|KRI1_uc002mox.1_Silent_p.I518I	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	522										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GCAGGTCGTCGATGATGTCCT	0.617													0	0	0	0.001786	0	27	46										A	10668297	G	A	10668297	2	1	29	1	0	0	0	0	0	0	0	1	8444	1048	37	1		1	KRI1	19	10668297	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	57	10668297	48460686	158	8154										
SPC24	147841	broad.mit.edu	37	chr19	11258787	11258787	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agctcttccagctctctggtGagctgagtagggcaggtcgt	14	10	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:11258787G>T	uc002mql.2	-	3	344	c.312C>A	c.(310-312)CTC>CTA	p.L104L		NM_182513	NP_872319	Q8NBT2	SPC24_HUMAN	spindle pole body component 24 homolog	104	Potential.|Interaction with the N-terminus of SPBC25.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding				0						GCTCTCTGGTGAGCTGAGTAG	0.607													1	0	2.0095e-06	0.001984	2.3254e-06	7	18										T	11258787	G	T	11258787	2	4	29	1	0	0	0	0	0	0	0	1	15020	1277	45	3		3	SPC24	19	11258787	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	590490	11258787	47870196	159	8155										
ZNF799	90576	broad.mit.edu	37	chr19	12491855	12491855	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtctttgaaggtttcccaaaGaattgaaggacttcctacat	8	8	1	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:12491855G>C	uc002mts.3	-	4	687	c.221C>G	c.(220-222)TCT>TGT	p.S74C				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	180	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						GTTTCCCAAAGAATTGAAGGA	0.403													0	0	0	0.00278	0	23	40										C	12491855	G	C	12491855	3	2	29	1	0	0	0	0	1	0	0	0	18163	957	33	1		1	ZNF799	19	12491855	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	1233068	12491855	46637128	160	8156										
ZNF791	163049	broad.mit.edu	37	chr19	12739532	12739532	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggaaaactttcaattatcctCtagatttgaaaatccacaag	5	8	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:12739532C>T	uc002mua.2	+	4	1351	c.1189C>T	c.(1189-1191)CTA>TTA	p.L397L	ZNF791_uc010xml.1_Silent_p.L365L|ZNF791_uc010dyu.1_Silent_p.L288L|ZNF791_uc010xmm.1_Silent_p.L288L	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	397	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAATTATCCTCTAGATTTGAA	0.363													0	0	0	0.00361	0	48	64										T	12739532	C	T	12739532	2	4	29	1	0	0	0	0	0	0	0	1	18160	912	32	1		1	ZNF791	19	12739532	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	247677	12739532	46389451	161	8157										
RAD23A	5886	broad.mit.edu	37	chr19	13059906	13059906	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccctgacagggaattcctggGagccccgagccggaacacgg	14	14	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:13059906G>A	uc002mvw.1	+	6	721	c.612G>A	c.(610-612)GGG>GGA	p.G204G	RAD23A_uc002mvx.1_Silent_p.G204G|RAD23A_uc002mvz.1_Silent_p.G204G|RAD23A_uc002mwa.1_Silent_p.G204G|RAD23A_uc002mvy.1_Silent_p.G39G|RAD23A_uc010xmw.1_Silent_p.G39G	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	204					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						GAATTCCTGGGAGCCCCGAGC	0.637								NER					0	0	0	0.001984	0	7	8										A	13059906	G	A	13059906	2	1	29	1	0	0	0	0	0	0	0	1	12982	1161	41	1		1	RAD23A	19	13059906	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	320374	13059906	46069077	162	8158										
ZNF93	81931	broad.mit.edu	37	chr19	20044762	20044762	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tatccttactacacataagaGaattcatactggagagaaac	6	8	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:20044762G>C	uc002non.2	+	4	1109	c.998G>C	c.(997-999)AGA>ACA	p.R333T		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	333	C2H2-type 7.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						ACACATAAGAGAATTCATACT	0.378													0	0	0	0.001786	0	31	10										C	20044762	G	C	20044762	3	2	29	1	0	0	0	0	1	0	0	0	18199	942	33	1	1012	1	ZNF93	19	20044762	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	6984856	20044762	39084221	163	8159										
ZNF30	90075	broad.mit.edu	37	chr19	35434903	35434903	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atactggtgagaaaccttttGaatgtaaggaatgtggaaag	12	3	0	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:35434903G>C	uc010edp.1	+	5	1411	c.1033G>C	c.(1033-1035)GAA>CAA	p.E345Q	ZNF30_uc002nxf.2_Missense_Mutation_p.E264Q|ZNF30_uc010edq.1_Missense_Mutation_p.E346Q|ZNF30_uc010edr.1_Missense_Mutation_p.E346Q	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	345	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		GAAACCTTTTGAATGTAAGGA	0.448													0	0	0	0.00361	0	54	66										C	35434903	G	C	35434903	3	2	29	1	0	0	0	0	1	0	0	0	17827	1291	45	1	1050	1	ZNF30	19	35434903	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	15390141	35434903	23694080	164	8160										
ZNF461	92283	broad.mit.edu	37	chr19	37129762	37129762	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cattccttacattcatagggTttctcaccagtatgaattct	5	10	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:37129762T>C	uc002oem.2	-	6	1713	c.1485A>G	c.(1483-1485)AAA>AAG	p.K495K	ZNF461_uc002oen.2_Silent_p.K464K|ZNF461_uc010xtj.1_Silent_p.K472K	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATTCATAGGGTTTCTCACCAG	0.393													0	0	0	0.00245	0	15	68										C	37129762	T	C	37129762	2	2	29	1	0	0	0	0	0	0	0	1	17922	1722	60	5		5	ZNF461	19	37129762	Silent	SNP	T	TCGA-CF-A27C-01A-11D-A16O-08	1694859	37129762	21999221	165	8161										
CATSPERG	57828	broad.mit.edu	37	chr19	38853103	38853103	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acgaaaagatctacaacctcGagtccgcgtacgagctgccg	10	13	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:38853103G>C	uc002oih.3	+	19	2332	c.2245G>C	c.(2245-2247)GAG>CAG	p.E749Q	CATSPERG_uc002oig.3_Missense_Mutation_p.E709Q|CATSPERG_uc002oif.3_Missense_Mutation_p.E389Q|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	749	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CTACAACCTCGAGTCCGCGTA	0.582													0	0	0	0.003271	0	36	54										C	38853103	G	C	38853103	3	2	29	1	0	0	0	0	1	0	0	0	2692	1059	37	1	2315	1	CATSPERG	19	38853103	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	1723341	38853103	20275880	166	8162										
SULT2B1	6820	broad.mit.edu	37	chr19	49090664	49090664	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	catcttcccatccagatcttCaccaaggccttcttcagctc	4	17	5	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:49090664C>T	uc002pjl.2	+	3	474	c.393C>T	c.(391-393)TTC>TTT	p.F131F	SULT2B1_uc002pjm.2_Silent_p.F116F	NM_177973	NP_814444	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	131					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		TCCAGATCTTCACCAAGGCCT	0.622													0	0	0	0.00361	0	47	66										T	49090664	C	T	49090664	2	4	29	1	0	0	0	0	0	0	0	1	15379	825	29	1		1	SULT2B1	19	49090664	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	10237561	49090664	10038319	167	8163										
RASIP1	54922	broad.mit.edu	37	chr19	49232663	49232663	+	Frame_Shift_Del	DEL	C	C	-													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cgttgtgcgtgactggggcgCcccgggacgggcgcaccatg							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:49232663delC	uc002pki.2	-	5	1561	c.1364delG	c.(1363-1365)GGCfs	p.G455fs		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	455					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GACTGGGGCGCCCCGGGACGG	0.701																		2	4	---	---								-	49232663	C	-	49232663	7	5	29	1	0	1	0	1	0	0	0	0	13078	739	26	0	1559	0	RASIP1	19	49232663	Frame_Shift_Del	DEL	C	TCGA-CF-A27C-01A-11D-A16O-08	141999	49232663	9896320	168	8164										
MBOAT7	79143	broad.mit.edu	37	chr19	54678031	54678031	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ggctgactccagccggccctCggcagccaggcacagcggga	15	16	0	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:54678031C>T	uc002qdq.2	-	9	1392	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Missense_Mutation_p.E60K|MBOAT7_uc010yem.1_Missense_Mutation_p.E358K|MBOAT7_uc002qdr.2_Missense_Mutation_p.E376K|MBOAT7_uc002qds.2_Missense_Mutation_p.E303K|MBOAT7_uc010yen.1_Missense_Mutation_p.E303K	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	376					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGCCGGCCCTCGGCAGCCAGG	0.687													0	0	0	0.00361	0	62	50										T	54678031	C	T	54678031	3	4	29	1	0	0	0	0	1	0	0	0	9358	893	31	1	296	1	MBOAT7	19	54678031	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	5445368	54678031	4450952	169	8165										
SLC24A3	57419	broad.mit.edu	37	chr20	19701741	19701741	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctccatcatgactgagttcaAcgtgttcacctttgtgaacc	7	12	3	3			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:19701741A>C	uc002wrl.2	+	17	2089	c.1892A>C	c.(1891-1893)AAC>ACC	p.N631T		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	631	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						ACTGAGTTCAACGTGTTCACC	0.582													0	0	0	0.00361	0	67	72										C	19701741	A	C	19701741	3	2	29	1	0	0	0	0	1	0	0	0	14467	43	2	5	1958	5	SLC24A3	20	19701741	Missense_Mutation	SNP	A	TCGA-CF-A27C-01A-11D-A16O-08		19701741	43323779	170	8166										
ASXL1	171023	broad.mit.edu	37	chr20	31017811	31017811	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gtggccaggccgaggtcaccCaggaccctgccccgctcctg	13	18	1	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:31017811C>T	uc002wxs.2	+	7	1099	c.673C>T	c.(673-675)CAG>TAG	p.Q225*	ASXL1_uc010geb.2_Intron	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	225					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CGAGGTCACCCAGGACCCTGC	0.687			F|N|Mis		MDS|CMML								0	0	0	0.00333	0	22	17										T	31017811	C	T	31017811	4	4	29	1	0	0	0	0	0	1	0	0	1066	595	21	2	709	2	ASXL1	20	31017811	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	11316070	31017811	32007709	171	8167										
RBPJL	11317	broad.mit.edu	37	chr20	43940948	43940948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tgcggctggtgctgcgcgggGgccgggagctgggtaccttc	20	11	0	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:43940948G>A	uc002xns.2	+	6	604	c.532G>A	c.(532-534)GGC>AGC	p.G178S	RBPJL_uc002xnt.2_Missense_Mutation_p.G178S	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	178					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				gctgcgCGGGGGCCGGGAGCT	0.512													0	0	0	0.004007	0	16	24										A	43940948	G	A	43940948	3	1	29	1	0	0	0	0	1	0	0	0	13162	1232	43	2	554	2	RBPJL	20	43940948	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	12923137	43940948	19084572	172	8168										
CSE1L	1434	broad.mit.edu	37	chr20	47707519	47707519	+	Missense_Mutation	SNP	C	C	A													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	caaatcttcattctgctattCcagagacttcagaattccaa							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707519C>A	uc002xty.2	+	21	2459	c.2325C>A	c.(2323-2325)TTC>TTA	p.F775L	CSE1L_uc010zyg.1_Missense_Mutation_p.F558L|CSE1L_uc010ghx.2_Missense_Mutation_p.F719L|CSE1L_uc010ghy.2_Missense_Mutation_p.F396L|CSE1L_uc010zyh.1_Missense_Mutation_p.F424L	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	775					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TTCTGCTATTCCAGAGACTTC	0.308													1	0	1.61788e-16	0.002445	1.9055e-16	16	62										A	47707519	C	A	47707519	3	1	29	1	0	0	0	0	1	0	0	0	3930	854	30	3	2403	3	CSE1L	20	47707519	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	3766571	47707519	15318001	173	8169	38	2								
CSE1L	1434	broad.mit.edu	37	chr20	47707529	47707529	+	Nonsense_Mutation	SNP	C	C	T													0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ttctgctattccagagacttCagaattccaaaacaaccaag							TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707529C>T	uc002xty.2	+	21	2469	c.2335C>T	c.(2335-2337)CAG>TAG	p.Q779*	CSE1L_uc010zyg.1_Nonsense_Mutation_p.Q562*|CSE1L_uc010ghx.2_Nonsense_Mutation_p.Q723*|CSE1L_uc010ghy.2_Nonsense_Mutation_p.Q400*|CSE1L_uc010zyh.1_Nonsense_Mutation_p.Q428*	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	779					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			CCAGAGACTTCAGAATTCCAA	0.303													0	0	0	0.001786	0	20	56										T	47707529	C	T	47707529	4	4	29	1	0	0	0	0	0	1	0	0	3930	827	29	1	2413	1	CSE1L	20	47707529	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	10	47707529	15317991	174	8170	38	2								
CSE1L	1434	broad.mit.edu	37	chr20	47707558	47707558	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	aaaacaaccaagtttatcaaGagtaagtaaaatcatctgga	6	6	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707558G>A	uc002xty.2	+	21	2498	c.2364G>A	c.(2362-2364)AAG>AAA	p.K788K	CSE1L_uc010zyg.1_Silent_p.K571K|CSE1L_uc010ghx.2_Silent_p.K732K|CSE1L_uc010ghy.2_Silent_p.K409K|CSE1L_uc010zyh.1_Silent_p.K437K	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	788					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			AGTTTATCAAGAGTAAGTAAA	0.308													0	0	0	0.003954	0	12	45										A	47707558	G	A	47707558	2	1	29	1	0	0	0	0	0	0	0	1	3930	956	33	1		1	CSE1L	20	47707558	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	29	47707558	15317962	175	8171										
DSCR3	10311	broad.mit.edu	37	chr21	38600636	38600636	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atgacacagtttgttgagttGagatgtcctcgaaggagaaa	12	5	0	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr21:38600636G>A	uc002ywf.1	-	7	785	c.546C>T	c.(544-546)CTC>CTT	p.L182L	DSCR3_uc010gnm.1_RNA|DSCR3_uc010gnn.1_Silent_p.L140L|DSCR3_uc010gnl.2_Silent_p.L155L|DSCR3_uc011aeg.1_Silent_p.L105L|DSCR3_uc011aeh.1_Silent_p.L57L	NM_006052	NP_006043	O14972	DSCR3_HUMAN	Down syndrome critical region protein 3	182					vacuolar transport	nucleus|retromer complex					0						TTGTTGAGTTGAGATGTCCTC	0.507													0	0	0	0.001786	0	28	39										A	38600636	G	A	38600636	2	1	29	1	0	0	0	0	0	0	0	1	4771	1277	45	1		1	DSCR3	21	38600636	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		38600636	9529259	176	8172										
CECR2	27443	broad.mit.edu	37	chr22	18031822	18031822	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	agcctccaacacttcccctgGatcaggtaaggatcactaaa	7	13	2	0			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:18031822G>C	uc010gqw.1	+	17	4444	c.4318G>C	c.(4318-4320)GAT>CAT	p.D1440H	CECR2_uc010gqv.1_Missense_Mutation_p.D1298H|CECR2_uc002zml.2_Missense_Mutation_p.D1299H|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1482					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		ACTTCCCCTGGATCAGGTAAG	0.498													0	0	0	0.003954	0	24	29										C	18031822	G	C	18031822	3	2	29	1	0	0	0	0	1	0	0	0	3206	1174	41	1	4386	1	CECR2	22	18031822	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		18031822	33272744	177	8173										
DGCR8	54487	broad.mit.edu	37	chr22	20073687	20073687	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctccctgctgaggaccccttCaacttctacggagcttctct	7	16	3	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:20073687C>T	uc002zri.2	+	2	551	c.201C>T	c.(199-201)TTC>TTT	p.F67F	DGCR8_uc010grz.2_Silent_p.F67F|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	67	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					AGGACCCCTTCAACTTCTACG	0.597													0	0	0	0.00361	0	50	56										T	20073687	C	T	20073687	2	4	29	1	0	0	0	0	0	0	0	1	4464	825	29	1		1	DGCR8	22	20073687	Silent	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	2041865	20073687	31230879	178	8174										
CYTSA	23384	broad.mit.edu	37	chr22	24717883	24717883	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	tggaggaggaactctgacttCttcagtggaaggctctgccc	13	10	4	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:24717883C>T	uc002zzw.2	+	5	1242	c.935C>T	c.(934-936)TCT>TTT	p.S312F	CYTSA_uc002zzv.3_Missense_Mutation_p.S312F|CYTSA_uc011ajq.1_Missense_Mutation_p.S312F	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	312					cell cycle|cell division						0						ACTCTGACTTCTTCAGTGGAA	0.478													0	0	0	0.00361	0	45	56										T	24717883	C	T	24717883	3	4	29	1	0	0	0	0	1	0	0	0	4209	913	32	1	945	1	CYTSA	22	24717883	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	4644196	24717883	26586683	179	8175										
CYTSA	23384	broad.mit.edu	37	chr22	24718351	24718351	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	acagattgaatacttccgctCtcttctagatgagcatcaca	6	11	3	4			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:24718351C>T	uc002zzw.2	+	5	1710	c.1403C>T	c.(1402-1404)TCT>TTT	p.S468F	CYTSA_uc002zzv.3_Missense_Mutation_p.S468F|CYTSA_uc011ajq.1_Missense_Mutation_p.S468F	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	468					cell cycle|cell division						0						TACTTCCGCTCTCTTCTAGAT	0.408													0	0	0	0.00361	0	65	70										T	24718351	C	T	24718351	3	4	29	1	0	0	0	0	1	0	0	0	4209	913	32	1	1413	1	CYTSA	22	24718351	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	468	24718351	26586215	180	8176										
DEPDC5	9681	broad.mit.edu	37	chr22	32160960	32160960	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	cagatattgtttctgttttaGaaactatcagtgtggaccag	9	6	2	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:32160960G>A	uc003als.2	+	5	336	c.194_splice	c.e5-1	p.E65_splice	DEPDC5_uc011als.1_Splice_Site_p.E65_splice|DEPDC5_uc011alu.1_Splice_Site_p.E65_splice|DEPDC5_uc011alv.1_Splice_Site|DEPDC5_uc003alt.2_Splice_Site_p.E65_splice|DEPDC5_uc003alr.1_Splice_Site_p.E65_splice|DEPDC5_uc011alt.1_Splice_Site_p.E65_splice	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1						intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						TTCTGTTTTAGAAACTATCAG	0.363													0	0	0	0.001984	0	6	88										A	32160960	G	A	32160960	5	1	29	1	0	0	0	0	0	0	1	0	4442	956	33	1	207	1	DEPDC5	22	32160960	Splice_Site	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	7442609	32160960	19143606	181	8177										
CXorf38	159013	broad.mit.edu	37	chrX	40506339	40506339	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	atctccatttctgttgacatGatgtctcaaaatctcccttt	4	11	4	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:40506339G>A	uc004dew.2	-	2	276	c.271C>T	c.(271-273)CAT>TAT	p.H91Y	CXorf38_uc011mko.1_Intron|CXorf38_uc004dev.1_5'UTR|CXorf38_uc010nhd.2_RNA	NM_144970	NP_659407	Q8TB03	CX038_HUMAN	hypothetical protein LOC159013	91										ovary(1)	1						CTGTTGACATGATGTCTCAAA	0.632													0	0	0	0.005443	0	27	0										A	40506339	G	A	40506339	3	1	29	1	0	0	0	0	1	0	0	0	4107	1290	45	1	708	1	CXorf38	23	40506339	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08		40506339	114764221	182	8178										
HUWE1	10075	broad.mit.edu	37	chrX	53631583	53631583	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	caagtatgaacaaacatcatGatgtaggcatgggcagcagt	11	7	1	2	rs141644800		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:53631583G>C	uc004dsp.2	-	26	3111	c.2709C>G	c.(2707-2709)ATC>ATG	p.I903M		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	903					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						CAAACATCATGATGTAGGCAT	0.473													0	0	0	0.003271	0	34	0										C	53631583	G	C	53631583	3	2	29	1	0	0	0	0	1	0	0	0	7461	1280	45	1	10651	1	HUWE1	23	53631583	Missense_Mutation	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	13125244	53631583	101638977	183	8179										
IL2RG	3561	broad.mit.edu	37	chrX	70327696	70327696	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccctccttttgggggaatctCactgacgaggcagagtcgtt	12	11	1	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:70327696C>G	uc004dyw.1	-	8	1014	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q	CXorf65_uc011mpo.1_5'Flank|CXorf65_uc011mpp.1_5'Flank|IL2RG_uc004dyv.1_Missense_Mutation_p.E63Q|IL2RG_uc004dyx.1_Missense_Mutation_p.E144Q	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	334	Cytoplasmic (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	GGGGGAATCTCACTGACGAGG	0.597									Severe_Combined_Immunodeficiency_X-linked				0	0	0	0.001786	0	31	0										G	70327696	C	G	70327696	3	3	29	1	0	0	0	0	1	0	0	0	7688	835	29	1	113	1	IL2RG	23	70327696	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	16696113	70327696	84942864	184	8180										
IL2RG	3561	broad.mit.edu	37	chrX	70327726	70327726	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	gcagagtcgttcactgtagtCtggctgcagactctcagcca	11	12	3	2			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:70327726C>G	uc004dyw.1	-	8	984	c.970G>C	c.(970-972)GAC>CAC	p.D324H	CXorf65_uc011mpo.1_5'Flank|CXorf65_uc011mpp.1_5'Flank|IL2RG_uc004dyv.1_Missense_Mutation_p.D53H|IL2RG_uc004dyx.1_Missense_Mutation_p.D134H	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	324	Cytoplasmic (Potential).				immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	TCACTGTAGTCTGGCTGCAGA	0.577									Severe_Combined_Immunodeficiency_X-linked				0	0	0	0.003271	0	36	0										G	70327726	C	G	70327726	3	3	29	1	0	0	0	0	1	0	0	0	7688	913	32	1	143	1	IL2RG	23	70327726	Missense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	30	70327726	84942834	185	8181										
STAG2	10735	broad.mit.edu	37	chrX	123197011	123197011	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ctaacttgttgcagttgcctCagtactttgatttggaaata	8	7	1	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:123197011C>T	uc004etz.3	+	18	2116	c.1777C>T	c.(1777-1779)CAG>TAG	p.Q593*	STAG2_uc004eua.2_Nonsense_Mutation_p.Q593*|STAG2_uc004eub.2_Nonsense_Mutation_p.Q593*|STAG2_uc004euc.2_Nonsense_Mutation_p.Q593*|STAG2_uc004eud.2_Nonsense_Mutation_p.Q593*|STAG2_uc004eue.2_Nonsense_Mutation_p.Q593*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	593					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GCAGTTGCCTCAGTACTTTGA	0.279													0	0	0	0.002445	0	31	1										T	123197011	C	T	123197011	4	4	29	1	0	0	0	0	0	1	0	0	15242	827	29	1	1843	1	STAG2	23	123197011	Nonsense_Mutation	SNP	C	TCGA-CF-A27C-01A-11D-A16O-08	52869285	123197011	32073549	186	8182										
RENBP	5973	broad.mit.edu	37	chrX	153205630	153205630	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.532608695652174	98	7.72841565209517e-36	3.8031119544592	4.73919022154316	3.10894155414975	0.483601424791029	0.689830814103477	72	ccactgtcactgtaacccatGaggaaggcaatcatggcttc	9	12	2	1			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:153205630G>A	uc004fjo.1	-	9	1172	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L		NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	334					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	TGTAACCCATGAGGAAGGCAA	0.602													0	0	0	0.00361	0	46	1										A	153205630	G	A	153205630	2	1	29	1	0	0	0	0	0	0	0	1	13225	1277	45	1		1	RENBP	23	153205630	Silent	SNP	G	TCGA-CF-A27C-01A-11D-A16O-08	30008619	153205630	2064930	187	8183										
PTGFR	5737	broad.mit.edu	37	chr1	78958508	78958508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	aacctgccagacggaaaaccGgctttccgtatttttttcag	8	11	1	1			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:78958508G>A	uc001din.2	+	2	346	c.80G>A	c.(79-81)CGG>CAG	p.R27Q	PTGFR_uc001dim.2_Missense_Mutation_p.R27Q	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	27	Extracellular (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	ACGGAAAACCGGCTTTCCGTA	0.438													0	0	0	0.001168	0	5	54										A	78958508	G	A	78958508	3	1	30	1	0	0	0	0	1	0	0	0	12749	1116	39	2	82	2	PTGFR	1	78958508	Missense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		78958508	170292113	1	8184										
NBPF14	25832	broad.mit.edu	37	chr1	148015635	148015635	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	aggtactcaccatccatgttAacagccaagccaacacgctg	7	14	1	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:148015635A>C	uc001eqq.2	-	8	1013	c.996T>G	c.(994-996)GTT>GTG	p.V332V	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Intron|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pae.1_Intron|NBPF14_uc010paf.1_Intron|NBPF14_uc001eqs.1_Silent_p.V211V	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	332	NBPF 3.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CATCCATGTTAACAGCCAAGC	0.468													0	0	0	0.004672	0	2	3										C	148015635	A	C	148015635	2	2	30	1	0	0	0	0	0	0	0	1	10194	349	13	5		5	NBPF14	1	148015635	Silent	SNP	A	TCGA-CF-A3MF-01A-12D-A21A-08	69057127	148015635	101234986	2	8185										
CDCA7	83879	broad.mit.edu	37	chr2	174223511	174223511	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ttgatttccatggaaacctcGtcatcctctgatgacagttg	8	10	2	3	rs142079460		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr2:174223511G>A	uc002uid.1	+	2	224	c.93G>A	c.(91-93)TCG>TCA	p.S31S	CDCA7_uc002uic.1_Silent_p.S31S|CDCA7_uc010zej.1_Silent_p.S31S|CDCA7_uc010zek.1_Intron	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	31					regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			TGGAAACCTCGTCATCCTCTG	0.383													0	0	0	0.012319	0	16	24										A	174223511	G	A	174223511	2	1	30	1	0	0	0	0	0	0	0	1	3090	1132	40	2		2	CDCA7	2	174223511	Silent	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		174223511	68975862	3	8186										
SEMA5B	54437	broad.mit.edu	37	chr3	122642517	122642517	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ccaggcagccctggggttctCctggtagcgaaatgggccat	14	12	1	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr3:122642517C>T	uc003efz.1	-	10	1523	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	SEMA5B_uc011bju.1_Missense_Mutation_p.E349K|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.E407K|SEMA5B_uc010hro.1_Missense_Mutation_p.E349K|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	407	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CTGGGGTTCTCCTGGTAGCGA	0.557													0	0	0	0.01441	0	57	146										T	122642517	C	T	122642517	3	4	30	1	0	0	0	0	1	0	0	0	14038	864	30	1	2292	1	SEMA5B	3	122642517	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08		122642517	75379913	4	8187										
ZFYVE28	57732	broad.mit.edu	37	chr4	2341289	2341289	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	gtcacggagggcgccccgcaCgtcctccaggctgcgcgtca	14	17	2	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr4:2341289C>A	uc003gex.1	-	4	731	c.412G>T	c.(412-414)GTG>TTG	p.V138L	ZFYVE28_uc011bvk.1_Missense_Mutation_p.V68L|ZFYVE28_uc011bvl.1_Missense_Mutation_p.V138L|ZFYVE28_uc003gey.3_Missense_Mutation_p.V68L|ZFYVE28_uc003gez.2_Missense_Mutation_p.V91L|ZFYVE28_uc003gew.1_Missense_Mutation_p.V24L	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	138					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GCGCCCCGCACGTCCTCCAGG	0.667													1	0	1.55795e-14	0.012319	1.80394e-14	21	9										A	2341289	C	A	2341289	3	1	30	1	0	0	0	0	1	0	0	0	17667	536	19	4	2511	4	ZFYVE28	4	2341289	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08		2341289	188812987	5	8188										
DEFB131	644414	broad.mit.edu	37	chr4	9452168	9452168	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	aatgctgatgaacatgcaatTagatactgtgctgacttcag	9	7	1	4			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr4:9452168T>C	uc011bwt.1	+	2	141	c.141T>C	c.(139-141)ATT>ATC	p.I47I		NM_001040448	NP_001035538	P59861	DB131_HUMAN	defensin, beta 131 precursor	47					defense response to bacterium	extracellular region					0						AACATGCAATTAGATACTGTG	0.373													0	0	0	0.006214	0	4	24										C	9452168	T	C	9452168	2	2	30	1	0	0	0	0	0	0	0	1	4416	1742	61	5		5	DEFB131	4	9452168	Silent	SNP	T	TCGA-CF-A3MF-01A-12D-A21A-08	7110879	9452168	181702108	6	8189										
CDKN1A	1026	broad.mit.edu	37	chr6	36652024	36652024	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ccaggaggcccgtgagcgatGgaacttcgactttgtcaccg	13	12	1	1			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr6:36652024G>A	uc003omm.3	+	2	268	c.146G>A	c.(145-147)TGG>TAG	p.W49*	CDKN1A_uc011dtq.1_Nonsense_Mutation_p.W83*|CDKN1A_uc003oml.2_Nonsense_Mutation_p.W49*|CDKN1A_uc003omn.2_Nonsense_Mutation_p.W49*	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	49					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						CGTGAGCGATGGAACTTCGAC	0.667									Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	82	12										A	36652024	G	A	36652024	4	1	30	1	0	0	0	0	0	1	0	0	3158	1357	47	2	148	2	CDKN1A	6	36652024	Nonsense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		36652024	134463043	7	8190										
MDGA1	266727	broad.mit.edu	37	chr6	37605212	37605212	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	tgggctggactggcagggggCtccactgcccggcatcacca	15	14	1	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr6:37605212C>T	uc003onu.1	-	17	3979	c.2800G>A	c.(2800-2802)GCC>ACC	p.A934T	MDGA1_uc003onv.1_3'UTR	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	934					brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						TGGCAGGGGGCTCCACTGCCC	0.652													0	0	0	0.009535	0	27	65										T	37605212	C	T	37605212	3	4	30	1	0	0	0	0	1	0	0	0	9406	797	28	2	71	2	MDGA1	6	37605212	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08	953188	37605212	133509855	8	8191										
MLL3	58508	broad.mit.edu	37	chr7	151962205	151962205	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	cgctatatccaggcacattcCatgatagtgctgaccacaag	8	12	0	2			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr7:151962205C>G	uc003wla.2	-	8	1321	c.1102G>C	c.(1102-1104)GGA>CGA	p.G368R		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	368	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGGCACATTCCATGATAGTGC	0.443			N		medulloblastoma								0	0	0	0.008361	0	25	597										G	151962205	C	G	151962205	3	3	30	1	0	0	0	0	1	0	0	0	9622	603	21	4	13841	4	MLL3	7	151962205	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08		151962205	7176458	9	8192										
DCAF12	25853	broad.mit.edu	37	chr9	34107398	34107398	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	cagcgtaggtagtcgatagaTggcaagactgttggggttgt	16	5	0	2			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr9:34107398T>C	uc003ztt.2	-	3	841	c.499A>G	c.(499-501)ATC>GTC	p.I167V		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	167	WD 1.					centrosome|CUL4 RING ubiquitin ligase complex					0						AGTCGATAGATGGCAAGACTG	0.507													0	0	0	0.01441	0	48	55										C	34107398	T	C	34107398	3	2	30	1	0	0	0	0	1	0	0	0	4263	1464	51	5	890	5	DCAF12	9	34107398	Missense_Mutation	SNP	T	TCGA-CF-A3MF-01A-12D-A21A-08		34107398	107106033	10	8193										
ANKRD2	26287	broad.mit.edu	37	chr10	99338106	99338106	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	gaaacgcaagcagaagaagcGggacgctctggccgcctcgc	14	13	1	2			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr10:99338106G>A	uc001knw.2	+	3	589	c.380G>A	c.(379-381)CGG>CAG	p.R127Q	ANKRD2_uc009xvu.2_Missense_Mutation_p.R127Q	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	127					muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CAGAAGAAGCGGGACGCTCTG	0.687													0	0	0	0.008291	0	9	60										A	99338106	G	A	99338106	3	1	30	1	0	0	0	0	1	0	0	0	647	1116	39	2	390	2	ANKRD2	10	99338106	Missense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		99338106	36196641	11	8194										
PNLIP	5406	broad.mit.edu	37	chr10	118314751	118314751	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ttagtccgattggaccccagCgatgccaaatttgtggatgt	11	9	0	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr10:118314751C>T	uc001lcm.2	+	7	676	c.633C>T	c.(631-633)AGC>AGT	p.S211S		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	211					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGGACCCCAGCGATGCCAAAT	0.483													0	0	0	0.00499	0	14	56										T	118314751	C	T	118314751	2	4	30	1	0	0	0	0	0	0	0	1	12149	767	27	2		2	PNLIP	10	118314751	Silent	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08	18976645	118314751	17219996	12	8195										
ATG16L2	89849	broad.mit.edu	37	chr11	72536397	72536397	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	cgttttggccccaacagcagCctcctggccactggaggggc	13	15	0	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr11:72536397C>A	uc001otd.2	+	10	1087	c.1047C>A	c.(1045-1047)AGC>AGA	p.S349R	ATG16L2_uc001ote.2_Missense_Mutation_p.S243R|ATG16L2_uc009ytj.1_Intron|ATG16L2_uc001otf.2_Missense_Mutation_p.S104R|ATG16L2_uc001otg.2_Missense_Mutation_p.S83R|ATG16L2_uc009ytk.2_Missense_Mutation_p.S104R	NM_033388	NP_203746	Q8NAA4	A16L2_HUMAN	ATG16 autophagy related 16-like 2	349	WD 1.				autophagy|protein transport	cytoplasm	protein binding				0			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			CCAACAGCAGCCTCCTGGCCA	0.627													1	0	1.39924e-13	0.01441	1.57863e-13	39	84										A	72536397	C	A	72536397	3	1	30	1	0	0	0	0	1	0	0	0	1092	738	26	4	1085	4	ATG16L2	11	72536397	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08		72536397	62470119	13	8196										
RFX4	5992	broad.mit.edu	37	chr12	107155161	107155161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	tgtatacacctctgacaacgCgcaggaattctgaatatgag	9	9	2	3			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr12:107155161C>T	uc001tlr.2	+	18	2188	c.2122C>T	c.(2122-2124)CGC>TGC	p.R708C	RFX4_uc001tlt.2_Missense_Mutation_p.R717C|RFX4_uc001tlv.2_Missense_Mutation_p.R614C	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	708					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						TCTGACAACGCGCAGGAATTC	0.512													0	0	0	0.003163	0	16	81										T	107155161	C	T	107155161	3	4	30	1	0	0	0	0	1	0	0	0	13265	768	27	2	2397	2	RFX4	12	107155161	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08		107155161	26696734	14	8197										
ZNF10	7556	broad.mit.edu	37	chr12	133732511	133732511	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	gtcaaaacattcaccttattCagtttgcaagaactcacaca	4	11	4	1			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr12:133732511C>T	uc009zzb.2	+	5	1126	c.679C>T	c.(679-681)CAG>TAG	p.Q227*	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Nonsense_Mutation_p.Q227*	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	227	C2H2-type 1; atypical.			Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TCACCTTATTCAGTTTGCAAG	0.358													0	0	0	0.00245	0	13	73										T	133732511	C	T	133732511	4	4	30	1	0	0	0	0	0	1	0	0	17709	827	29	1	693	1	ZNF10	12	133732511	Nonsense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08	26577350	133732511	119384	15	8198										
HSD11B2	3291	broad.mit.edu	37	chr16	67470804	67470804	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ttcttcatcagtcactgtctGcctcgagcactgcagcctgg	9	14	5	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr16:67470804G>A	uc002etd.2	+	5	1232	c.1116G>A	c.(1114-1116)CTG>CTA	p.L372L		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	372					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	GTCACTGTCTGCCTCGAGCAC	0.662													0	0	0	0.01441	0	49	134										A	67470804	G	A	67470804	2	1	30	1	0	0	0	0	0	0	0	1	7377	1306	46	2		2	HSD11B2	16	67470804	Silent	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		67470804	22883949	16	8199										
KLHDC4	54758	broad.mit.edu	37	chr16	87743024	87743024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	agccagcatggcgttggagcGtggacacggcccaggtgcgg	18	11	0	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr16:87743024G>A	uc002fki.2	-	10	1340	c.1294C>T	c.(1294-1296)CGC>TGC	p.R432C	KLHDC4_uc002fkh.1_RNA|KLHDC4_uc010cht.1_Intron|KLHDC4_uc002fkj.2_Missense_Mutation_p.R401C|KLHDC4_uc002fkk.2_Missense_Mutation_p.R251C|KLHDC4_uc002fkl.2_Missense_Mutation_p.R375C|KLHDC4_uc010chu.1_Missense_Mutation_p.R251C	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	432										pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GCGTTGGAGCGTGGACACGGC	0.682													0	0	0	0.01441	0	42	137										A	87743024	G	A	87743024	3	1	30	1	0	0	0	0	1	0	0	0	8358	1145	40	2	276	2	KLHDC4	16	87743024	Missense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08	20272220	87743024	2611729	17	8200										
AXIN2	8313	broad.mit.edu	37	chr17	63532493	63532493	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	gcgacaggcctcctccagctGagccagcgtgttgggtgggg	17	12	0	1			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr17:63532493G>A	uc002jfi.2	-	8	2375	c.2086C>T	c.(2086-2088)CAG>TAG	p.Q696*	AXIN2_uc002jfh.2_Nonsense_Mutation_p.Q631*	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	696				Q -> H (in Ref. 2; AAF22799).	cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						TCCTCCAGCTGAGCCAGCGTG	0.667									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				0	0	0	0.000602	0	5	73										A	63532493	G	A	63532493	4	1	30	1	0	0	0	0	0	1	0	0	1237	1299	45	1	461	1	AXIN2	17	63532493	Nonsense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		63532493	17662717	18	8201										
KRI1	65095	broad.mit.edu	37	chr19	10664773	10664773	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	cacagtggggcccagcagccGtgccttcttggccctcctcc	11	18	1	0	rs147727983		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:10664773G>A	uc002moy.1	-	19	1993	c.1984C>T	c.(1984-1986)CGG>TGG	p.R662W	KRI1_uc002mow.1_Missense_Mutation_p.R281W|KRI1_uc002mox.1_Missense_Mutation_p.R658W	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	662										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCCAGCAGCCGTGCCTTCTTG	0.642													0	0	0	0.01441	0	49	183										A	10664773	G	A	10664773	3	1	30	1	0	0	0	0	1	0	0	0	8444	1144	40	2	149	2	KRI1	19	10664773	Missense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		10664773	48464210	19	8202										
GATAD2A	54815	broad.mit.edu	37	chr19	19606680	19606680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	aggtcgtcatgcccccactcGtcaggggggctcaggtaagc	14	13	3	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:19606680G>A	uc010xqt.1	+	6	1054	c.742G>A	c.(742-744)GTC>ATC	p.V248I	GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Missense_Mutation_p.V267I|GATAD2A_uc010xqw.1_Missense_Mutation_p.V75I	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	248					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCCCCCACTCGTCAGGGGGGC	0.672													0	0	0	0.012319	0	17	56										A	19606680	G	A	19606680	3	1	30	1	0	0	0	0	1	0	0	0	6260	1145	40	2	760	2	GATAD2A	19	19606680	Missense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08	8941907	19606680	39522303	20	8203										
ACPT	93650	broad.mit.edu	37	chr19	51298106	51298106	+	Frame_Shift_Del	DEL	C	C	-													0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ctgcccctgcctctcagcctCcccgggtgcccggccccctg							TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:51298106delC	uc002pta.1	+	10	1050	c.1050delC	c.(1048-1050)CTCfs	p.L350fs		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	350	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTCTCAGCCTCCCCGGGTGCC	0.682																		7	828	---	---								-	51298106	C	-	51298106	7	5	30	1	0	1	0	1	0	0	0	0	168	842	30	0	1088	0	ACPT	19	51298106	Frame_Shift_Del	DEL	C	TCGA-CF-A3MF-01A-12D-A21A-08	31691426	51298106	7830877	21	8204										
ZMYND8	23613	broad.mit.edu	37	chr20	45853033	45853033	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ctggcaggggtagtcacagtAgctagtgttccaacagcagt	13	9	1	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:45853033A>G	uc002xta.1	-	19	3387	c.3133T>C	c.(3133-3135)TAC>CAC	p.Y1045H	ZMYND8_uc010ghq.1_Missense_Mutation_p.Y676H|ZMYND8_uc010ghr.1_Missense_Mutation_p.Y947H|ZMYND8_uc002xst.1_Missense_Mutation_p.Y927H|ZMYND8_uc002xsu.1_Missense_Mutation_p.Y918H|ZMYND8_uc002xsv.1_Missense_Mutation_p.Y973H|ZMYND8_uc002xsw.1_Missense_Mutation_p.Y751H|ZMYND8_uc002xsx.1_Missense_Mutation_p.Y751H|ZMYND8_uc002xsy.1_Missense_Mutation_p.Y974H|ZMYND8_uc002xsz.1_Missense_Mutation_p.Y936H|ZMYND8_uc010zxy.1_Missense_Mutation_p.Y1072H|ZMYND8_uc002xtb.1_Missense_Mutation_p.Y1019H|ZMYND8_uc002xss.2_Missense_Mutation_p.Y1045H|ZMYND8_uc010zxz.1_Missense_Mutation_p.Y913H|ZMYND8_uc002xtc.1_Missense_Mutation_p.Y1019H|ZMYND8_uc002xtd.1_Missense_Mutation_p.Y994H|ZMYND8_uc002xte.1_Missense_Mutation_p.Y999H|ZMYND8_uc010zya.1_Missense_Mutation_p.Y1045H|ZMYND8_uc002xtf.1_Missense_Mutation_p.Y1065H|ZMYND8_uc002xsr.1_Missense_Mutation_p.Y144H	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1045	MYND-type.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TAGTCACAGTAGCTAGTGTTC	0.587													0	0	0	0.01441	0	50	202										G	45853033	A	G	45853033	3	3	30	1	0	0	0	0	1	0	0	0	17708	420	15	5	531	5	ZMYND8	20	45853033	Missense_Mutation	SNP	A	TCGA-CF-A3MF-01A-12D-A21A-08		45853033	17172487	22	8205										
DIDO1	11083	broad.mit.edu	37	chr20	61525841	61525841	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	tctttcaacatgctgctgaaGacgtcgagaagcggcgctgt	12	10	2	3			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:61525841G>A	uc002ydr.1	-	11	2760	c.2496C>T	c.(2494-2496)GTC>GTT	p.V832V	DIDO1_uc002yds.1_Silent_p.V832V|DIDO1_uc002ydt.1_Silent_p.V832V|DIDO1_uc002ydu.1_Silent_p.V832V	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	832					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TGCTGCTGAAGACGTCGAGAA	0.498													0	0	0	0.012319	0	18	69										A	61525841	G	A	61525841	2	1	30	1	0	0	0	0	0	0	0	1	4522	929	33	1		1	DIDO1	20	61525841	Silent	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08	15672808	61525841	1499679	23	8206										
OPRL1	4987	broad.mit.edu	37	chr20	62730140	62730140	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	aagacctctgagacggtaccGcggcccgcatgactaggcgt	13	13	1	3	rs138878509		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:62730140G>A	uc002yic.2	+	5	1503	c.1101G>A	c.(1099-1101)CCG>CCA	p.P367P	OPRL1_uc002yid.2_Silent_p.P367P|OPRL1_uc002yif.3_Silent_p.P362P	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	367	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					AGACGGTACCGCGGCCCGCAT	0.657													0	0	0	0.00499	0	15	76										A	62730140	G	A	62730140	2	1	30	1	0	0	0	0	0	0	0	1	10886	1074	38	2		2	OPRL1	20	62730140	Silent	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08	1204299	62730140	295380	24	8207										
SMTN	6525	broad.mit.edu	37	chr22	31500334	31500334	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ctgtgtgcccctggtggaggTggacgacatgatgatcatgg	16	8	1	2			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr22:31500334T>A	uc003ajl.1	+	20	2854	c.2636T>A	c.(2635-2637)GTG>GAG	p.V879E	SMTN_uc003ajk.1_3'UTR|SMTN_uc003ajm.1_Missense_Mutation_p.V902E|SMTN_uc011ale.1_Missense_Mutation_p.V964E|SMTN_uc011alf.1_3'UTR|SMTN_uc003ajn.1_3'UTR|SMTN_uc011alg.1_3'UTR|SMTN_uc003ajo.1_3'UTR|SMTN_uc010gwe.1_3'UTR|SMTN_uc003ajp.1_RNA	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	879	CH.				muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						CTGGTGGAGGTGGACGACATG	0.632													0	0	0	0.01441	0	40	170										A	31500334	T	A	31500334	3	1	30	1	0	0	0	0	1	0	0	0	14814	1696	59	5	2859	5	SMTN	22	31500334	Missense_Mutation	SNP	T	TCGA-CF-A3MF-01A-12D-A21A-08		31500334	19804232	25	8208										
SLC5A1	6523	broad.mit.edu	37	chr22	32498214	32498214	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	cctcctcaccaaacccattcCggatgtgcatgtgagtatcc	7	15	1	1			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr22:32498214C>T	uc003amc.2	+	13	1887	c.1655C>T	c.(1654-1656)CCG>CTG	p.P552L	SLC5A1_uc011alz.1_Missense_Mutation_p.P425L	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	552	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						AAACCCATTCCGGATGTGCAT	0.378													0	0	0	0.004007	0	15	165										T	32498214	C	T	32498214	3	4	30	1	0	0	0	0	1	0	0	0	14661	652	23	2	1705	2	SLC5A1	22	32498214	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08	997880	32498214	18806352	26	8209										
XG	7499	broad.mit.edu	37	chrX	2729397	2729397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	gcaatatggtagcaaaaatcGtgtctcccatcgtatccgtg	9	10	1	0			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:2729397G>A	uc011mhg.1	+	9	653	c.430G>A	c.(430-432)GTG>ATG	p.V144M	XG_uc004cqp.2_Missense_Mutation_p.V159M	NM_175569	NP_780778	P55808	XG_HUMAN	XG glycoprotein isoform 1 precursor	144	Helical; (Potential).					integral to membrane|plasma membrane				ovary(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AGCAAAAATCGTGTCTCCCAT	0.418													0	0	0	0.00333	0	18	18										A	2729397	G	A	2729397	3	1	30	1	0	0	0	0	1	0	0	0	17424	1145	40	2	516	2	XG	23	2729397	Missense_Mutation	SNP	G	TCGA-CF-A3MF-01A-12D-A21A-08		2729397	152541163	27	8210										
FAM47C	442444	broad.mit.edu	37	chrX	37028026	37028026	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ctcatctccgcccagagcctTctgagactggagtgtcccat	9	15	3	2	rs141294322		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:37028026T>C	uc004ddl.1	+	1	1557	c.1543T>C	c.(1543-1545)TCT>CCT	p.S515P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	515										ovary(3)	3						CCCAGAGCCTTCTGAGACTGG	0.612													0	0	0	0.009096	0	4	96										C	37028026	T	C	37028026	3	2	30	1	0	0	0	0	1	0	0	0	5571	1783	62	5	1545	5	FAM47C	23	37028026	Missense_Mutation	SNP	T	TCGA-CF-A3MF-01A-12D-A21A-08	34298629	37028026	118242534	28	8211										
ACRC	93953	broad.mit.edu	37	chrX	70823916	70823916	+	Missense_Mutation	SNP	A	A	T													0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	gacagcagtgatgattcggaAgctcccgacgacagcagtga							TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:70823916A>T	uc004eae.2	+	8	1290	c.789A>T	c.(787-789)GAA>GAT	p.E263D	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	263	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					ATGATTCGGAAGCTCCCGACG	0.552													0	0	0	0.001984	0	6	96										T	70823916	A	T	70823916	3	4	30	1	0	0	0	0	1	0	0	0	171	69	3	5	815	5	ACRC	23	70823916	Missense_Mutation	SNP	A	TCGA-CF-A3MF-01A-12D-A21A-08	33795890	70823916	84446644	29	8212	39	2								
ACRC	93953	broad.mit.edu	37	chrX	70823918	70823918	+	Missense_Mutation	SNP	C	C	T													0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	cagcagtgatgattcggaagCtcccgacgacagcagtgatg							TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:70823918C>T	uc004eae.2	+	8	1292	c.791C>T	c.(790-792)GCT>GTT	p.A264V	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	264	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GATTCGGAAGCTCCCGACGAC	0.557													0	0	0	0.001984	0	6	96										T	70823918	C	T	70823918	3	4	30	1	0	0	0	0	1	0	0	0	171	797	28	2	817	2	ACRC	23	70823918	Missense_Mutation	SNP	C	TCGA-CF-A3MF-01A-12D-A21A-08	2	70823918	84446642	30	8213	39	2								
MAGEC1	9947	broad.mit.edu	37	chrX	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-													0.1	3	0.344854673219249	1.48468185388845	0	1.56716417910448	0.1	0.217754357439058	0	ctcactactttcctcagagcCctcctcagggggaggactcc							TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:140994844_140994846delCCT	uc004fbt.2	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)CCTdel	p.P553del	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)								9	442	---	---								-	140994846	CCT	-	140994844	7	5	30	1	0	1	0	1	0	0	0	0	9180	623	22	0	1660	0	MAGEC1	23	140994844	In_Frame_Del	DEL	CCT	TCGA-CF-A3MF-01A-12D-A21A-08	70170926	140994844	14275716	31	8214										
VPS13D	55187	broad.mit.edu	37	chr1	12463960	12463960	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cgatactactttgaaaatctCaaaatcagcattcctcagat	4	10	3	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:12463960C>G	uc001atv.2	+	63	12105	c.11964C>G	c.(11962-11964)CTC>CTG	p.L3988L	VPS13D_uc001atw.2_Silent_p.L3963L|VPS13D_uc001atx.2_Silent_p.L3175L|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3987					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTGAAAATCTCAAAATCAGCA	0.388													0	0	0	0.013537	0	11	30										G	12463960	C	G	12463960	2	3	31	1	0	0	0	0	0	0	0	1	17189	813	29	1		1	VPS13D	1	12463960	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		12463960	236786661	1	8215										
FBXO42	54455	broad.mit.edu	37	chr1	16641859	16641859	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgtcccttccagcacagtttCttcctggtccacagccatga	7	15	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:16641859C>G	uc001ayg.2	-	2	271	c.55G>C	c.(55-57)GAA>CAA	p.E19Q	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.E19Q	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	19										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		AGCACAGTTTCTTCCTGGTCC	0.483													0	0	0	0.016723	0	12	28										G	16641859	C	G	16641859	3	3	31	1	0	0	0	0	1	0	0	0	5751	922	32	1	2134	1	FBXO42	1	16641859	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	4177899	16641859	232608762	2	8216										
MAN1C1	57134	broad.mit.edu	37	chr1	25944326	25944326	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gcccggcttcgtcccggcctCcccgtgggggctgcggctgc	16	18	0	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:25944326C>T	uc001bkm.2	+	1	368	c.38C>T	c.(37-39)TCC>TTC	p.S13F	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	13	Cytoplasmic (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GTCCCGGCCTCCCCGTGGGGG	0.701													0	0	0	0.010729	0	10	14										T	25944326	C	T	25944326	3	4	31	1	0	0	0	0	1	0	0	0	9213	855	30	1	40	1	MAN1C1	1	25944326	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	9302467	25944326	223306295	3	8217										
ARID1A	8289	broad.mit.edu	37	chr1	27099981	27099981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctatggaggtccttatgacaGagtgaggtaagcatgacccc	12	9	0	4			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:27099981G>C	uc001bmv.1	+	15	4233	c.3860G>C	c.(3859-3861)AGA>ACA	p.R1287T	ARID1A_uc001bmt.1_Missense_Mutation_p.R1286T|ARID1A_uc001bmu.1_Missense_Mutation_p.R1287T|ARID1A_uc001bmw.1_Missense_Mutation_p.R904T|ARID1A_uc001bmx.1_Missense_Mutation_p.R133T|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1287					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTTATGACAGAGTGAGGTAA	0.582			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.014758	0	5	19										C	27099981	G	C	27099981	3	2	31	1	0	0	0	0	1	0	0	0	913	942	33	1	3918	1	ARID1A	1	27099981	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1155655	27099981	222150640	4	8218										
AHDC1	27245	broad.mit.edu	37	chr1	27876618	27876618	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	caccaaaaccgcctgctttgCccccacgccgccggaagccc	8	21	0	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:27876618C>T	uc009vsy.2	-	6	2978	c.2009G>A	c.(2008-2010)GGC>GAC	p.G670D	AHDC1_uc009vsz.1_Missense_Mutation_p.G670D	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	670	Gly-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GCCTGCTTTGCCCCCACGCCG	0.642													0	0	0	0.009096	0	3	50										T	27876618	C	T	27876618	3	4	31	1	0	0	0	0	1	0	0	0	412	739	26	2	2806	2	AHDC1	1	27876618	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	776637	27876618	221374003	5	8219										
EIF3I	8668	broad.mit.edu	37	chr1	32691917	32691917	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gacctgcgggatccgagccaGattggtgagggctgggaata	17	8	0	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:32691917G>C	uc001bur.3	+	6	929	c.396G>C	c.(394-396)CAG>CAC	p.Q132H	EIF3I_uc009vuc.2_Missense_Mutation_p.Q132H|EIF3I_uc001bus.2_Missense_Mutation_p.Q84H	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	132						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				ATCCGAGCCAGATTGGTGAGG	0.542													0	0	0	0.021523	0	24	72										C	32691917	G	C	32691917	3	2	31	1	0	0	0	0	1	0	0	0	5019	933	33	1	414	1	EIF3I	1	32691917	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	4815299	32691917	216558704	6	8220										
EIF3I	8668	broad.mit.edu	37	chr1	32692108	32692108	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcgctggccatgagagtggaGagctcaaccagtatagtgcc	13	10	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:32692108G>C	uc001bur.3	+	7	1038	c.505G>C	c.(505-507)GAG>CAG	p.E169Q	EIF3I_uc009vuc.2_Missense_Mutation_p.E169Q|EIF3I_uc001bus.2_Missense_Mutation_p.E121Q	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	169	WD 3.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				TGAGAGTGGAGAGCTCAACCA	0.423													0	0	0	0.01441	0	52	155										C	32692108	G	C	32692108	3	2	31	1	0	0	0	0	1	0	0	0	5019	943	33	1	527	1	EIF3I	1	32692108	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	191	32692108	216558513	7	8221										
SMAP2	64744	broad.mit.edu	37	chr1	40882742	40882742	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgtatggggtccagccagctCagcagctgcaatggaacctt	12	11	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:40882742C>T	uc001cfj.2	+	9	1203	c.1138C>T	c.(1138-1140)CAG>TAG	p.Q380*	SMAP2_uc001cfk.2_Nonsense_Mutation_p.Q350*|SMAP2_uc010oji.1_Nonsense_Mutation_p.Q297*|SMAP2_uc010ojj.1_Nonsense_Mutation_p.Q196*	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	380	Interaction with PICALM (By similarity).|Met-rich.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			CCAGCCAGCTCAGCAGCTGCA	0.522													0	0	0	0.016723	0	10	27										T	40882742	C	T	40882742	4	4	31	1	0	0	0	0	0	1	0	0	14767	827	29	1	1172	1	SMAP2	1	40882742	Nonsense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	8190634	40882742	208367879	8	8222										
ASB17	127247	broad.mit.edu	37	chr1	76397769	76397769	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tttttccacaaatgcaatgtAatctgtgagtagtgcgtcaa	8	7	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:76397769A>G	uc001dhe.1	-	1	348	c.208T>C	c.(208-210)TAC>CAC	p.Y70H	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	70					intracellular signal transduction					ovary(1)	1						AATGCAATGTAATCTGTGAGT	0.388													0	0	0	0.016723	0	11	61										G	76397769	A	G	76397769	3	3	31	1	0	0	0	0	1	0	0	0	1021	362	13	5	691	5	ASB17	1	76397769	Missense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	35515027	76397769	172852852	9	8223										
FAM73A	374986	broad.mit.edu	37	chr1	78267138	78267138	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagaaaggaaaaatattaccAtgggaaccagagcacctcat	8	8	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:78267138A>G	uc001dhx.2	+	3	350	c.318A>G	c.(316-318)CCA>CCG	p.P106P	FAM73A_uc010ork.1_Silent_p.P106P|FAM73A_uc010orl.1_Silent_p.P68P|FAM73A_uc001dhy.1_5'Flank	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	106						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		AAATATTACCATGGGAACCAG	0.353													0	0	0	0.016723	0	14	26										G	78267138	A	G	78267138	2	3	31	1	0	0	0	0	0	0	0	1	5617	204	8	5		5	FAM73A	1	78267138	Silent	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	1869369	78267138	170983483	10	8224										
GBP7	388646	broad.mit.edu	37	chr1	89598973	89598973	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	actcaacatctttctcagttCtctcatatagttttcccttt	2	12	5	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:89598973C>G	uc001dna.2	-	10	1769	c.1630G>C	c.(1630-1632)GAA>CAA	p.E544Q	GBP2_uc001dmy.1_Intron	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	544						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TTTCTCAGTTCTCTCATATAG	0.448													0	0	0	0.030466	0	33	61										G	89598973	C	G	89598973	3	3	31	1	0	0	0	0	1	0	0	0	6279	922	32	1	294	1	GBP7	1	89598973	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	11331835	89598973	159651648	11	8225										
LPPR4	9890	broad.mit.edu	37	chr1	99771891	99771891	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttggtgcacatccctgaggaGactcaggaaaacataagcac	10	10	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:99771891G>C	uc001dse.2	+	7	1723	c.1617G>C	c.(1615-1617)GAG>GAC	p.E539D	LPPR4_uc010oue.1_Missense_Mutation_p.E481D	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	539							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCCCTGAGGAGACTCAGGAAA	0.557													0	0	0	0.030466	0	40	126										C	99771891	G	C	99771891	3	2	31	1	0	0	0	0	1	0	0	0	8927	933	33	1	1643	1	LPPR4	1	99771891	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	10172918	99771891	149478730	12	8226										
FLG	2312	broad.mit.edu	37	chr1	152286242	152286242	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tggacttgatcttgcctgttCatgggatgatgcagtctgtc	12	8	3	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:152286242C>A	uc001ezu.1	-	3	1156	c.1120G>T	c.(1120-1122)GAA>TAA	p.E374*	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	374	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGCCTGTTCATGGGATGAT	0.567									Ichthyosis				1	0	1.02779e-63	0.01441	1.13056e-63	143	385										A	152286242	C	A	152286242	4	1	31	1	0	0	0	0	0	1	0	0	5922	835	29	3	11069	3	FLG	1	152286242	Nonsense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	52514351	152286242	96964379	13	8227										
FLG2	388698	broad.mit.edu	37	chr1	152323603	152323603	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctgtctgtccatgagtagttCcctgtctcccatgacctgag	9	13	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:152323603C>T	uc001ezw.3	-	3	6732	c.6659G>A	c.(6658-6660)GGA>GAA	p.G2220E	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2220							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGAGTAGTTCCCTGTCTCCC	0.532													0	0	0	0.01441	0	105	282										T	152323603	C	T	152323603	3	4	31	1	0	0	0	0	1	0	0	0	5923	855	30	1	520	1	FLG2	1	152323603	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	37361	152323603	96927018	14	8228										
PGLYRP4	57115	broad.mit.edu	37	chr1	153309655	153309655	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	actgaccaaagcatccacttAcctgtgaaggtgcccatgaa	8	12	0	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:153309655A>G	uc001fbo.2	-	8	1008	c.943_splice	c.e8+1	p.G315_splice	PGLYRP4_uc001fbp.2_Splice_Site_p.G311_splice	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta						defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCATCCACTTACCTGTGAAGG	0.507													0	0	0	0.01441	0	46	31										G	153309655	A	G	153309655	5	3	31	1	0	0	0	0	0	0	1	0	11796	405	14	5	184	5	PGLYRP4	1	153309655	Splice_Site	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	986052	153309655	95940966	15	8229										
DCST2	127579	broad.mit.edu	37	chr1	155001803	155001803	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	actaggaacagcacgaggagGaggtgtcggataaggttgaa	16	5	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155001803G>A	uc001fgm.2	-	8	1328	c.1248C>T	c.(1246-1248)CTC>CTT	p.L416L	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	416	Helical; (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACGAGGAGGAGGTGTCGGA	0.547													0	0	0	0.021022	0	36	94										A	155001803	G	A	155001803	2	1	31	1	0	0	0	0	0	0	0	1	4303	1161	41	1		1	DCST2	1	155001803	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1692148	155001803	94248818	16	8230										
FAM189B	10712	broad.mit.edu	37	chr1	155218018	155218018	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtgggcacagggcgccgtttCtcggctgaccgggcacgtag	17	12	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155218018C>G	uc001fjm.2	-	11	2262	c.1656G>C	c.(1654-1656)GAG>GAC	p.E552D	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_Missense_Mutation_p.E354D|FAM189B_uc001fjn.2_Missense_Mutation_p.E456D|FAM189B_uc001fjo.2_Missense_Mutation_p.E534D|FAM189B_uc001fjp.2_RNA	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	552						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						GGCGCCGTTTCTCGGCTGACC	0.652													0	0	0	0.024245	0	14	12										G	155218018	C	G	155218018	3	3	31	1	0	0	0	0	1	0	0	0	5517	912	32	1	358	1	FAM189B	1	155218018	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	216215	155218018	94032603	17	8231										
YY1AP1	55249	broad.mit.edu	37	chr1	155646459	155646459	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgctgtttggctgaaggtttCttcatcttcagctgttcaaa	9	8	5	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155646459C>G	uc001fln.2	-	5	426	c.402G>C	c.(400-402)AAG>AAC	p.K134N	YY1AP1_uc010pgg.1_Missense_Mutation_p.K2N|YY1AP1_uc010pgh.1_Missense_Mutation_p.K57N|YY1AP1_uc010pgi.1_Missense_Mutation_p.K206N|YY1AP1_uc001flh.2_Missense_Mutation_p.K206N|YY1AP1_uc009wqt.2_Missense_Mutation_p.K57N|YY1AP1_uc001flk.2_Missense_Mutation_p.K57N|YY1AP1_uc001fll.2_Missense_Mutation_p.K68N|YY1AP1_uc009wqv.2_5'UTR|YY1AP1_uc001flm.2_Missense_Mutation_p.K57N|YY1AP1_uc001fli.2_Missense_Mutation_p.K68N|YY1AP1_uc009wqu.2_5'UTR|YY1AP1_uc001flj.2_Missense_Mutation_p.K68N|YY1AP1_uc009wqw.2_Missense_Mutation_p.K57N|YY1AP1_uc001flo.2_Missense_Mutation_p.K2N|YY1AP1_uc001flp.2_Missense_Mutation_p.K68N|YY1AP1_uc010pgj.1_Missense_Mutation_p.K134N|YY1AP1_uc009wqx.2_Missense_Mutation_p.K206N|YY1AP1_uc010pgk.1_Missense_Mutation_p.K206N	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	134					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CTGAAGGTTTCTTCATCTTCA	0.458													0	0	0	0.010504	0	18	59										G	155646459	C	G	155646459	3	3	31	1	0	0	0	0	1	0	0	0	17505	912	32	1	2076	1	YY1AP1	1	155646459	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	428441	155646459	93604162	18	8232										
POGK	57645	broad.mit.edu	37	chr1	166819004	166819004	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	acaccaggcagggaaaaactGaaaatcacagcaatgcttgg	10	9	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:166819004G>C	uc001gdt.1	+	5	1308	c.1188G>C	c.(1186-1188)CTG>CTC	p.L396L	POGK_uc010ple.1_Silent_p.L311L|POGK_uc010plf.1_Silent_p.L278L	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	396	DDE.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGGAAAAACTGAAAATCACAG	0.498													0	0	0	0.013537	0	12	34										C	166819004	G	C	166819004	2	2	31	1	0	0	0	0	0	0	0	1	12185	1277	45	1		1	POGK	1	166819004	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	11172545	166819004	82431617	19	8233										
MAEL	84944	broad.mit.edu	37	chr1	166974581	166974581	+	Frame_Shift_Del	DEL	T	T	-													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctcaaggagccctctaagacTtggattcgaagcctcctaga							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:166974581delT	uc001gdy.1	+	8	863	c.792delT	c.(790-792)ACTfs	p.T264fs	MAEL_uc001gdz.1_Frame_Shift_Del_p.T233fs|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	264					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						CCTCTAAGACTTGGATTCGAA	0.398																		22	22	---	---								-	166974581	T	-	166974581	7	5	31	1	0	1	0	1	0	0	0	0	9154	1596	56	0	822	0	MAEL	1	166974581	Frame_Shift_Del	DEL	T	TCGA-CF-A3MG-01A-11D-A20D-08	155577	166974581	82276040	20	8234										
RABGAP1L	9910	broad.mit.edu	37	chr1	174210653	174210653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atccagcaatgtggagatagCatcttttccaatctataagg	8	8	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:174210653C>T	uc001gjx.2	+	5	770	c.575C>T	c.(574-576)GCA>GTA	p.A192V	RABGAP1L_uc009wwq.1_Missense_Mutation_p.A192V|RABGAP1L_uc001gjw.2_Missense_Mutation_p.A155V	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	192	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						GTGGAGATAGCATCTTTTCCA	0.363													0	0	0	0.013537	0	10	23										T	174210653	C	T	174210653	3	4	31	1	0	0	0	0	1	0	0	0	12965	710	25	2	589	2	RABGAP1L	1	174210653	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	7236072	174210653	75039968	21	8235										
USH2A	7399	broad.mit.edu	37	chr1	215955497	215955497	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cagtgatgttccccgaaaacGttcaattccatttcgaagaa	7	10	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:215955497G>A	uc001hku.1	-	54	11014	c.10627C>T	c.(10627-10629)CGT>TGT	p.R3543C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3543	Extracellular (Potential).|Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCCGAAAACGTTCAATTCCA	0.373										HNSCC(13;0.011)			0	0	0	0.021553	0	6	32										A	215955497	G	A	215955497	3	1	31	1	0	0	0	0	1	0	0	0	17033	1145	40	2	5057	2	USH2A	1	215955497	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	41744844	215955497	33295124	22	8236										
TBCE	6905	broad.mit.edu	37	chr1	235577915	235577915	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggagactatcggttttgactCtattatgaaacagcaaaggt	10	6	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:235577915C>G	uc001hwz.1	+	4	476	c.353C>G	c.(352-354)TCT>TGT	p.S118C	TBCE_uc010pxq.1_RNA|TBCE_uc001hxa.1_Missense_Mutation_p.S118C|TBCE_uc010pxr.1_Missense_Mutation_p.S118C|TBCE_uc001hxb.1_5'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	118					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			GGTTTTGACTCTATTATGAAA	0.269													0	0	0	0.028581	0	15	20										G	235577915	C	G	235577915	3	3	31	1	0	0	0	0	1	0	0	0	15631	913	32	1	363	1	TBCE	1	235577915	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	19622418	235577915	13672706	23	8237										
KIF26B	55083	broad.mit.edu	37	chr1	245849192	245849192	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccccggttaagccaagcagcGggggcaagcccactctctga	12	15	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:245849192G>A	uc001ibf.1	+	12	3347	c.2907G>A	c.(2905-2907)GCG>GCA	p.A969A	KIF26B_uc001ibg.1_Silent_p.A587A|KIF26B_uc001ibh.1_Silent_p.A211A	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	969					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GCCAAGCAGCGGGGGCAAGCC	0.587													0	0	0	0.009096	0	3	16										A	245849192	G	A	245849192	2	1	31	1	0	0	0	0	0	0	0	1	8295	1103	39	2		2	KIF26B	1	245849192	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	10271277	245849192	3401429	24	8238										
PXDN	7837	broad.mit.edu	37	chr2	1652231	1652232	+	Missense_Mutation	DNP	CC	CC	AG													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atgccgccctcattcacaatCcggaagggagagaagaaagc							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:1652231_1652232CC>AG	uc002qxa.2	-	17	3384_3385	c.3320_3321GG>CT	c.(3319-3321)CGG>CCT	p.R1107P		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1107					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CATTCACAATCCGGAAGGGAGA	0.589													0	0	0	0.004672	0	13	21										AG	1652232	CC	AG	1652231	3	1	31	1	0	0	0	0	1	0	0	0	12847	842	30	3	1146	3	PXDN	2	1652231	Missense_Mutation	DNP	CC	TCGA-CF-A3MG-01A-11D-A20D-08		1652231	241547142	25	8239										
OTX1	5013	broad.mit.edu	37	chr2	63282824	63282824	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agctcggcgtccagctcttcCgccaacccagcggctgcagc	11	18	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:63282824C>T	uc002scd.2	+	5	686	c.438C>T	c.(436-438)TCC>TCT	p.S146S	OTX1_uc010ypt.1_Silent_p.S80S	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	146						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					CCAGCTCTTCCGCCAACCCAG	0.677													0	0	0	0.028581	0	14	22										T	63282824	C	T	63282824	2	4	31	1	0	0	0	0	0	0	0	1	11320	639	23	2		2	OTX1	2	63282824	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	61630593	63282824	179916549	26	8240										
SLC1A4	6509	broad.mit.edu	37	chr2	65245358	65245358	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gcggtgttcattgcgcaactCaacaacgtagagctcaacgc	10	12	3	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:65245358C>G	uc010yqa.1	+	6	1510	c.1188C>G	c.(1186-1188)CTC>CTG	p.L396L	SLC1A4_uc010ypy.1_Silent_p.L176L|SLC1A4_uc010ypz.1_Silent_p.L98L|SLC1A4_uc010fcv.2_Silent_p.L396L|SLC1A4_uc002sdh.2_Silent_p.L176L	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	396					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	TTGCGCAACTCAACAACGTAG	0.498													0	0	0	0.013537	0	11	96										G	65245358	C	G	65245358	2	3	31	1	0	0	0	0	0	0	0	1	14434	813	29	1		1	SLC1A4	2	65245358	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	1962534	65245358	177954015	27	8241										
AAK1	22848	broad.mit.edu	37	chr2	69759277	69759277	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	acatagtggcctcggtcatgCaagaggatgttttcaacctg	11	9	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:69759277C>T	uc002sfp.2	-	6	1057	c.552G>A	c.(550-552)TTG>TTA	p.L184L	AAK1_uc010fdk.2_Silent_p.L184L|AAK1_uc010yqm.1_Silent_p.L184L	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	184	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						CTCGGTCATGCAAGAGGATGT	0.413													0	0	0	0.006214	0	10	25										T	69759277	C	T	69759277	2	4	31	1	0	0	0	0	0	0	0	1	16	709	25	2		2	AAK1	2	69759277	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	4513919	69759277	173440096	28	8242										
EMX1	2016	broad.mit.edu	37	chr2	73160942	73160942	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtgtggttccagaaccggagGacaaagtacaaacggcagaa	13	8	0	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:73160942G>A	uc002sin.1	+	3	1110	c.732G>A	c.(730-732)AGG>AGA	p.R244R	EMX1_uc002sim.1_Missense_Mutation_p.D197N	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	211	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGAACCGGAGGACAAAGTACA	0.607													0	0	0	0.030593	0	28	10										A	73160942	G	A	73160942	2	1	31	1	0	0	0	0	0	0	0	1	5107	1165	41	1		1	EMX1	2	73160942	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	3401665	73160942	170038431	29	8243										
KDM3A	55818	broad.mit.edu	37	chr2	86678259	86678259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgttggacaaagctggtttgGgatccataacttctgttcgc	11	8	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:86678259G>A	uc002sri.3	+	4	703	c.376G>A	c.(376-378)GGA>AGA	p.G126R	KDM3A_uc010ytj.1_Missense_Mutation_p.G126R|KDM3A_uc010ytk.1_Missense_Mutation_p.G74R	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	126					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						AGCTGGTTTGGGATCCATAAC	0.368													0	0	0	0.023175	0	31	7										A	86678259	G	A	86678259	3	1	31	1	0	0	0	0	1	0	0	0	8126	1233	43	2	386	2	KDM3A	2	86678259	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	13517317	86678259	156521114	30	8244										
AFF3	3899	broad.mit.edu	37	chr2	100218011	100218013	+	In_Frame_Del	DEL	GCT	GCT	-													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctggaggagctgctgctgccGctgctgctgctgctgctgct							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:100218011_100218013delGCT	uc002tag.2	-	13	1491_1493	c.1255_1257delAGC	c.(1255-1257)AGCdel	p.S419del	AFF3_uc002taf.2_In_Frame_Del_p.S444del|AFF3_uc010fiq.1_In_Frame_Del_p.S419del|AFF3_uc010yvr.1_In_Frame_Del_p.S572del|AFF3_uc002tah.1_In_Frame_Del_p.S444del	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	419	Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						tgctgctgccgctgctgctgctg	0.562																		3	6	---	---								-	100218013	GCT	-	100218011	7	5	31	1	0	1	0	1	0	0	0	0	358	1078	38	0	2471	0	AFF3	2	100218011	In_Frame_Del	DEL	GCT	TCGA-CF-A3MG-01A-11D-A20D-08	13539752	100218011	142981362	31	8245										
TGFBRAP1	9392	broad.mit.edu	37	chr2	105900801	105900801	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctctttagcttccaggaactGaagttgtgcaaactgtataa	8	8	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:105900801G>A	uc002tcq.2	-	5	1177	c.1093C>T	c.(1093-1095)CAG>TAG	p.Q365*	TGFBRAP1_uc010fjc.2_Nonsense_Mutation_p.Q135*|TGFBRAP1_uc002tcr.3_Nonsense_Mutation_p.Q365*	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	365					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						TCCAGGAACTGAAGTTGTGCA	0.468													0	0	0	0.027356	0	23	66										A	105900801	G	A	105900801	4	1	31	1	0	0	0	0	0	1	0	0	15821	1299	45	1	1521	1	TGFBRAP1	2	105900801	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	5682790	105900801	137298572	32	8246										
RGPD4	285190	broad.mit.edu	37	chr2	108487551	108487551	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atgatgatgcctataagactGaggacagcgatgacatccat	10	8	0	5			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:108487551G>A	uc010ywk.1	+	20	3173	c.3091G>A	c.(3091-3093)GAG>AAG	p.E1031K	RGPD4_uc002tdu.2_Missense_Mutation_p.E218K|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1031					intracellular transport		binding			skin(2)	2						CTATAAGACTGAGGACAGCGA	0.393													0	0	0	0.01441	0	60	148										A	108487551	G	A	108487551	3	1	31	1	0	0	0	0	1	0	0	0	13288	1291	45	1	3169	1	RGPD4	2	108487551	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	2586750	108487551	134711822	33	8247										
KIF5C	3800	broad.mit.edu	37	chr2	149861968	149861968	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgtccaggatctgaccacccGagttaaaaaagtgagttctc	9	10	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:149861968G>A	uc010zbu.1	+	22	2803	c.2435G>A	c.(2434-2436)CGA>CAA	p.R812Q	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Missense_Mutation_p.R94Q	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	812					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTGACCACCCGAGTTAAAAAA	0.403													0	0	0	0.004672	0	3	16										A	149861968	G	A	149861968	3	1	31	1	0	0	0	0	1	0	0	0	8307	1058	37	1	2443	1	KIF5C	2	149861968	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	41374417	149861968	93337405	34	8248										
TTN	7273	broad.mit.edu	37	chr2	179438341	179438341	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttacttggacttctgaggctAcatttgtccatgccaatctg	8	10	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179438341A>G	uc010zfg.1	-	275	65038	c.64814T>C	c.(64813-64815)GTA>GCA	p.V21605A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V15300A|TTN_uc010zfi.1_Missense_Mutation_p.V15233A|TTN_uc010zfj.1_Missense_Mutation_p.V15108A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22532							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGAGGCTACATTTGTCCA	0.408													0	0	0	0.01441	0	137	51										G	179438341	A	G	179438341	3	3	31	1	0	0	0	0	1	0	0	0	16732	391	14	5	35609	5	TTN	2	179438341	Missense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	29576373	179438341	63761032	35	8249										
TTN	7273	broad.mit.edu	37	chr2	179501130	179501130	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagactagaaattaccttctAcaacaagtttagccgtggag	8	8	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179501130A>G	uc010zfg.1	-	174	33844	c.33620T>C	c.(33619-33621)GTA>GCA	p.V11207A	TTN_uc010zfh.1_Missense_Mutation_p.V4902A|TTN_uc010zfi.1_Missense_Mutation_p.V4835A|TTN_uc010zfj.1_Missense_Mutation_p.V4710A|TTN_uc010fre.1_Missense_Mutation_p.V1068A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12134							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTACCTTCTACAACAAGTTT	0.343													0	0	0	0.00308	0	7	3										G	179501130	A	G	179501130	3	3	31	1	0	0	0	0	1	0	0	0	16732	391	14	5	66921	5	TTN	2	179501130	Missense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	62789	179501130	63698243	36	8250										
TTN	7273	broad.mit.edu	37	chr2	179596192	179596192	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcgtcttcagtgatttcatcGctgtcttttagccaagtcac	7	11	5	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179596192G>A	uc010zfg.1	-	56	13793	c.13569C>T	c.(13567-13569)AGC>AGT	p.S4523S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S1184S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5450							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTCATCGCTGTCTTTTA	0.483													0	0	0	0.004672	0	3	36										A	179596192	G	A	179596192	2	1	31	1	0	0	0	0	0	0	0	1	16732	1078	38	2		2	TTN	2	179596192	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	95062	179596192	63603181	37	8251										
CDK15	65061	broad.mit.edu	37	chr2	202698639	202698639	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cacgttcttcacagggacctGaaacctcagaacttactcat	6	13	4	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:202698639G>C	uc002uyt.2	+	7	724	c.675G>C	c.(673-675)CTG>CTC	p.L225L	CDK15_uc010ftm.2_Silent_p.L90L|CDK15_uc002uys.2_Silent_p.L174L|CDK15_uc010ftn.1_Silent_p.L174L|CDK15_uc010fto.1_Silent_p.L204L	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	225	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding	p.E225D(1)		breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	ACAGGGACCTGAAACCTCAGA	0.493													0	0	0	0.010818	0	27	55										C	202698639	G	C	202698639	2	2	31	1	0	0	0	0	0	0	0	1	3131	1277	45	1		1	CDK15	2	202698639	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	23102447	202698639	40500734	38	8252										
ALS2CR8	79800	broad.mit.edu	37	chr2	203831743	203831743	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtgtcagtatgggccaagaaGaaaaggtttccagttaaaaa	11	5	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:203831743G>A	uc002uzo.2	+	9	1155	c.875G>A	c.(874-876)AGA>AAA	p.R292K	ALS2CR8_uc010zhy.1_3'UTR|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.R216K|ALS2CR8_uc010zib.1_Missense_Mutation_p.R216K|ALS2CR8_uc010zic.1_Missense_Mutation_p.R204K|ALS2CR8_uc002uzp.2_Missense_Mutation_p.R292K	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	292										large_intestine(1)|ovary(1)	2						GGGCCAAGAAGAAAAGGTTTC	0.408													0	0	0	0.009535	0	27	59										A	203831743	G	A	203831743	3	1	31	1	0	0	0	0	1	0	0	0	555	942	33	1	901	1	ALS2CR8	2	203831743	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1133104	203831743	39367630	39	8253										
SPHKAP	80309	broad.mit.edu	37	chr2	228886493	228886493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agcggtgagaaagtcttcctCgattgaagataaggaacagt	12	6	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:228886493C>T	uc002vpq.2	-	6	678	c.631G>A	c.(631-633)GAG>AAG	p.E211K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E211K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E211K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	211						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AAGTCTTCCTCGATTGAAGAT	0.468													0	0	0	0.027356	0	26	33										T	228886493	C	T	228886493	3	4	31	1	0	0	0	0	1	0	0	0	15047	893	31	1	4499	1	SPHKAP	2	228886493	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	25054750	228886493	14312880	40	8254										
FARP2	9855	broad.mit.edu	37	chr2	242373632	242373632	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agagatgaatgtaagaacttCtggaagatttgtgtggagta	13	2	1	4			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:242373632C>T	uc002wbi.1	+	10	1044	c.927C>T	c.(925-927)TTC>TTT	p.F309F	FARP2_uc010zoq.1_Silent_p.F309F|FARP2_uc010zor.1_Silent_p.F309F	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	309	FERM.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GTAAGAACTTCTGGAAGATTT	0.398													0	0	0	0.037714	0	27	52										T	242373632	C	T	242373632	2	4	31	1	0	0	0	0	0	0	0	1	5677	912	32	1		1	FARP2	2	242373632	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	13487139	242373632	825741	41	8255										
FARP2	9855	broad.mit.edu	37	chr2	242373728	242373728	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttcagccggggctcctccttCagatacaggtaggggccatg	13	12	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:242373728C>G	uc002wbi.1	+	10	1140	c.1023C>G	c.(1021-1023)TTC>TTG	p.F341L	FARP2_uc010zoq.1_Missense_Mutation_p.F341L|FARP2_uc010zor.1_Missense_Mutation_p.F341L	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	341					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GCTCCTCCTTCAGATACAGGT	0.458													0	0	0	0.008291	0	11	23										G	242373728	C	G	242373728	3	3	31	1	0	0	0	0	1	0	0	0	5677	825	29	1	1057	1	FARP2	2	242373728	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	96	242373728	825645	42	8256										
HDAC11	79885	broad.mit.edu	37	chr3	13544448	13544448	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	catcatggatgtctacaaccGccacatctacccaggggacc	8	15	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:13544448G>A	uc003bxy.2	+	8	750	c.617G>A	c.(616-618)CGC>CAC	p.R206H	HDAC11_uc010heb.2_Missense_Mutation_p.A164T|HDAC11_uc011aux.1_Missense_Mutation_p.R14H|HDAC11_uc011auy.1_Missense_Mutation_p.R155H	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	206	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						GTCTACAACCGCCACATCTAC	0.547													0	0	0	0.027356	0	25	210										A	13544448	G	A	13544448	3	1	31	1	0	0	0	0	1	0	0	0	7006	1087	38	2	647	2	HDAC11	3	13544448	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		13544448	184477982	43	8257										
ANKRD28	23243	broad.mit.edu	37	chr3	15720866	15720866	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	taatgtatcaattaacatctCagcagcaccttcgttgtcat	5	10	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:15720866C>T	uc003caj.1	-	23	2556	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K	ANKRD28_uc003cai.1_Missense_Mutation_p.E651K|ANKRD28_uc011avz.1_Missense_Mutation_p.E651K|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_Intron	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	805	ANK 23.					nucleoplasm	protein binding			breast(1)	1						ATTAACATCTCAGCAGCACCT	0.343													0	0	0	0.01441	0	43	143										T	15720866	C	T	15720866	3	4	31	1	0	0	0	0	1	0	0	0	656	835	29	1	772	1	ANKRD28	3	15720866	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	2176418	15720866	182301564	44	8258										
NGLY1	55768	broad.mit.edu	37	chr3	25761126	25761126	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cataggagtgaagactgttaTctgttagagggaaaaaaaaa	11	3	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:25761126T>C	uc003cdl.2	-	12	1898	c.1790A>G	c.(1789-1791)GAT>GGT	p.D597G	NGLY1_uc010hfg.2_Missense_Mutation_p.D579G|NGLY1_uc003cdm.2_Missense_Mutation_p.I538V|NGLY1_uc011awo.1_Missense_Mutation_p.D555G|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	597	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						AAGACTGTTATCTGTTAGAGG	0.343													0	0	0	0.007413	0	19	26										C	25761126	T	C	25761126	3	2	31	1	0	0	0	0	1	0	0	0	10398	1449	50	5	178	5	NGLY1	3	25761126	Missense_Mutation	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	10040260	25761126	172261304	45	8259										
ZCWPW2	152098	broad.mit.edu	37	chr3	28520378	28520378	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atgtctactctatggatattCtcatgagcaaagactggaaa	8	7	3	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:28520378C>G	uc003ceh.2	+	5	734	c.566C>G	c.(565-567)TCT>TGT	p.S189C	ZCWPW2_uc003cei.2_Missense_Mutation_p.S189C|ZCWPW2_uc010hfo.2_5'UTR	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	189							zinc ion binding			ovary(2)	2						TATGGATATTCTCATGAGCAA	0.294													0	0	0	0.004482	0	7	40										G	28520378	C	G	28520378	3	3	31	1	0	0	0	0	1	0	0	0	17595	913	32	1	576	1	ZCWPW2	3	28520378	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	2759252	28520378	169502052	46	8260										
STT3B	201595	broad.mit.edu	37	chr3	31638349	31638349	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgctgctgcttatcctatttCtatatggtaagatttcatat	6	7	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:31638349C>T	uc011axe.1	+	4	771	c.771C>T	c.(769-771)TTC>TTT	p.F257F	STT3B_uc010hft.1_Silent_p.F257F|STT3B_uc003cer.1_Silent_p.F257F|STT3B_uc003cet.2_Silent_p.F8F	NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	257	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						TATCCTATTTCTATATGGTAA	0.313													0	0	0	0.024245	0	13	43										T	31638349	C	T	31638349	2	4	31	1	0	0	0	0	0	0	0	1	15333	912	32	1		1	STT3B	3	31638349	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	3117971	31638349	166384081	47	8261										
TRIM71	131405	broad.mit.edu	37	chr3	32932410	32932410	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cactgtgcaaccagcacattGagaacagccctttcaaggtg	9	12	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:32932410G>C	uc003cff.2	+	4	1777	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	572	Filamin.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CCAGCACATTGAGAACAGCCC	0.582													0	0	0	0.012319	0	21	86										C	32932410	G	C	32932410	3	2	31	1	0	0	0	0	1	0	0	0	16541	1291	45	1	1728	1	TRIM71	3	32932410	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1294061	32932410	165090020	48	8262										
KBTBD5	131377	broad.mit.edu	37	chr3	42727789	42727789	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcttcgagagcgtgcgctgcCgcttgctgccgcgcgccttt	13	15	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:42727789C>T	uc003clv.1	+	1	779	c.679C>T	c.(679-681)CGC>TGC	p.R227C		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	227	BACK.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CGTGCGCTGCCGCTTGCTGCC	0.706													0	0	0	0.02938	0	7	4										T	42727789	C	T	42727789	3	4	31	1	0	0	0	0	1	0	0	0	7996	652	23	2	681	2	KBTBD5	3	42727789	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	9795379	42727789	155294641	49	8263										
C3orf39	84892	broad.mit.edu	37	chr3	43122017	43122017	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgccagcagcagctctgcctCattcagaatgagtctgttct	9	12	5	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:43122017C>A	uc003cmq.1	-	2	1048	c.907G>T	c.(907-909)GAG>TAG	p.E303*	C3orf39_uc003cmr.1_Nonsense_Mutation_p.E303*	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	303						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		AGCTCTGCCTCATTCAGAATG	0.552													1	0	6.44725e-10	0.014323	6.94575e-10	23	80										A	43122017	C	A	43122017	4	1	31	1	0	0	0	0	0	1	0	0	2229	835	29	3	839	3	C3orf39	3	43122017	Nonsense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	394228	43122017	154900413	50	8264										
ZNF167	55888	broad.mit.edu	37	chr3	44612265	44612265	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agaagccttatgagtgtagtGaatgtggcaaagccttcagt	12	6	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:44612265G>A	uc010hin.2	+	6	2051	c.1663G>A	c.(1663-1665)GAA>AAA	p.E555K	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.E555K|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	555	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TGAGTGTAGTGAATGTGGCAA	0.438													0	0	0	0.013537	0	13	82										A	44612265	G	A	44612265	3	1	31	1	0	0	0	0	1	0	0	0	17738	1291	45	1	1681	1	ZNF167	3	44612265	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1490248	44612265	153410165	51	8265										
SCAP	22937	broad.mit.edu	37	chr3	47470073	47470073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggacaaaggtgaacgaaataCatctactgccaggaggttct	11	8	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:47470073C>T	uc003crh.1	-	4	595	c.340G>A	c.(340-342)GTA>ATA	p.V114I	SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	114	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GAACGAAATACATCTACTGCC	0.547													0	0	0	0.01441	0	61	88										T	47470073	C	T	47470073	3	4	31	1	0	0	0	0	1	0	0	0	13877	478	17	2	3579	2	SCAP	3	47470073	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	2857808	47470073	150552357	52	8266										
GLYCTK	132158	broad.mit.edu	37	chr3	52325777	52325777	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgagaggtgggggttcagctCtgctgcctgcccccatccca	13	14	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:52325777C>G	uc003ddo.2	+	4	640	c.544C>G	c.(544-546)CTG>GTG	p.L182V	GLYCTK_uc003ddq.2_Intron|GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Missense_Mutation_p.L182V|GLYCTK_uc003ddr.2_5'Flank	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	182					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		GGGTTCAGCTCTGCTGCCTGC	0.577											OREG0015611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	22	83										G	52325777	C	G	52325777	3	3	31	1	0	0	0	0	1	0	0	0	6482	912	32	1	554	1	GLYCTK	3	52325777	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	4855704	52325777	145696653	53	8267										
ERC2	26059	broad.mit.edu	37	chr3	56026169	56026169	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccagcaaccggtccacttccGcttgggccttgccacactcg	9	18	0	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:56026169G>A	uc003dhr.1	-	11	2427	c.2171C>T	c.(2170-2172)GCG>GTG	p.A724V	ERC2_uc003dht.1_Missense_Mutation_p.A207V	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	724	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTCCACTTCCGCTTGGGCCTT	0.478													0	0	0	0.01441	0	98	103										A	56026169	G	A	56026169	3	1	31	1	0	0	0	0	1	0	0	0	5211	1087	38	2	720	2	ERC2	3	56026169	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	3700392	56026169	141996261	54	8268										
PDZRN3	23024	broad.mit.edu	37	chr3	73432662	73432662	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	catctttttgtggctcagttCgagaatgttcatctccttcc	7	11	4	1	rs146957114		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:73432662C>T	uc003dpl.1	-	10	3151	c.3055G>A	c.(3055-3057)GAA>AAA	p.E1019K	PDZRN3_uc011bgh.1_Missense_Mutation_p.E676K|PDZRN3_uc010hoe.1_Missense_Mutation_p.E717K|PDZRN3_uc011bgf.1_Missense_Mutation_p.E736K|PDZRN3_uc011bgg.1_Missense_Mutation_p.E739K	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1019	Potential.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TGGCTCAGTTCGAGAATGTTC	0.498													0	0	0	0.021553	0	6	315										T	73432662	C	T	73432662	3	4	31	1	0	0	0	0	1	0	0	0	11709	893	31	1	149	1	PDZRN3	3	73432662	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	17406493	73432662	124589768	55	8269										
ROBO1	6091	broad.mit.edu	37	chr3	78666910	78666910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagaactaacactggagcgtCcgctggaaatgttgtcctcc	10	11	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:78666910C>T	uc003dqe.2	-	27	4365	c.4157G>A	c.(4156-4158)GGA>GAA	p.G1386E	ROBO1_uc003dqb.2_Missense_Mutation_p.G1347E|ROBO1_uc003dqc.2_Missense_Mutation_p.G1286E|ROBO1_uc003dqd.2_Missense_Mutation_p.G1341E|ROBO1_uc010hoh.2_Missense_Mutation_p.G578E|ROBO1_uc011bgl.1_Missense_Mutation_p.G958E	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1386	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACTGGAGCGTCCGCTGGAAAT	0.577													0	0	0	0.006214	0	9	30										T	78666910	C	T	78666910	3	4	31	1	0	0	0	0	1	0	0	0	13513	855	30	1	818	1	ROBO1	3	78666910	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	5234248	78666910	119355520	56	8270										
OR5H6	79295	broad.mit.edu	37	chr3	97983269	97983269	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ataccgctcttcctggcattCttggtaatatatctcatcac	5	12	4	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:97983269C>G	uc003dsi.1	+	1	141	c.141C>G	c.(139-141)TTC>TTG	p.F47L		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TCCTGGCATTCTTGGTAATAT	0.413													0	0	0	0.01441	0	70	187										G	97983269	C	G	97983269	3	3	31	1	0	0	0	0	1	0	0	0	11163	912	32	1	143	1	OR5H6	3	97983269	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	19316359	97983269	100039161	57	8271										
COPB2	9276	broad.mit.edu	37	chr3	139085454	139085454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tctggtcctctgttcttttgGaatggtaggaaggaccttat	11	7	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:139085454G>A	uc003etf.3	-	15	1970	c.1840C>T	c.(1840-1842)CCA>TCA	p.P614S	COPB2_uc011bmv.1_Missense_Mutation_p.P585S|COPB2_uc010hui.2_Missense_Mutation_p.P585S	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	614					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TGTTCTTTTGGAATGGTAGGA	0.403													0	0	0	0.02938	0	6	34										A	139085454	G	A	139085454	3	1	31	1	0	0	0	0	1	0	0	0	3729	1174	41	1	912	1	COPB2	3	139085454	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	41102185	139085454	58936976	58	8272										
MECOM	2122	broad.mit.edu	37	chr3	169099220	169099220	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcaggagagcatggctcttGaatattgagggagggagtgc	18	5	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:169099220G>A	uc011bpj.1	-	2	533	c.130C>T	c.(130-132)CAA>TAA	p.Q44*	MECOM_uc003ffl.2_Nonsense_Mutation_p.Q16*|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Nonsense_Mutation_p.Q44*|MECOM_uc011bpl.1_Nonsense_Mutation_p.Q44*	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGGCTCTTGAATATTGAGG	0.473													0	0	0	0.009096	0	4	35										A	169099220	G	A	169099220	4	1	31	1	0	0	0	0	0	1	0	0	9422	1299	45	1	3663	1	MECOM	3	169099220	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	30013766	169099220	28923210	59	8273										
MAP3K13	9175	broad.mit.edu	37	chr3	185181390	185181390	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgagaagatcaaaagtgaagGaacttgtatacaccggttag	11	5	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:185181390G>A	uc010hyf.2	+	9	1597	c.1331G>A	c.(1330-1332)GGA>GAA	p.G444E	MAP3K13_uc011brt.1_Missense_Mutation_p.G237E|MAP3K13_uc011bru.1_Missense_Mutation_p.G300E|MAP3K13_uc003fpi.2_Missense_Mutation_p.G444E|MAP3K13_uc010hyg.2_Missense_Mutation_p.G134E	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	444	Leucine-zipper 1.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAAGTGAAGGAACTTGTATA	0.443													0	0	0	0.02938	0	7	74										A	185181390	G	A	185181390	3	1	31	1	0	0	0	0	1	0	0	0	9247	1174	41	1	1357	1	MAP3K13	3	185181390	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	16082170	185181390	12841040	60	8274										
SEMA5A	9037	broad.mit.edu	37	chr5	9190451	9190451	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gactgccacgtgggaaaagcGgctattgtcctccatgaagg	13	10	0	1	rs141668225		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:9190451G>A	uc003jek.2	-	11	1913	c.1201C>T	c.(1201-1203)CGC>TGC	p.R401C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	401	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGGGAAAAGCGGCTATTGTCC	0.567													0	0	0	0.027356	0	26	69										A	9190451	G	A	9190451	3	1	31	1	0	0	0	0	1	0	0	0	14037	1116	39	2	2075	2	SEMA5A	5	9190451	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		9190451	171724809	61	8275										
ROPN1L	83853	broad.mit.edu	37	chr5	10450167	10450167	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gctcttacaactggatccttGtgaaaacaaaatcaagtgga	8	8	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:10450167G>C	uc003jex.3	+	3	630	c.359G>C	c.(358-360)TGT>TCT	p.C120S		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	120					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CTGGATCCTTGTGAAAACAAA	0.408													0	0	0	0.012319	0	20	103										C	10450167	G	C	10450167	3	2	31	1	0	0	0	0	1	0	0	0	13525	1377	48	4	369	4	ROPN1L	5	10450167	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1259716	10450167	170465093	62	8276										
SPEF2	79925	broad.mit.edu	37	chr5	35709167	35709167	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	accagaaaaagagaaggaaaTtcatcaaagccatgtggctt	9	7	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:35709167T>C	uc003jjo.2	+	19	2894	c.2783T>C	c.(2782-2784)ATT>ACT	p.I928T	SPEF2_uc003jjq.3_Missense_Mutation_p.I923T|SPEF2_uc003jjp.1_Missense_Mutation_p.I414T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	928					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGAAGGAAATTCATCAAAGC	0.423													0	0	0	0.021553	0	6	82										C	35709167	T	C	35709167	3	2	31	1	0	0	0	0	1	0	0	0	15034	1493	52	5	2878	5	SPEF2	5	35709167	Missense_Mutation	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	25259000	35709167	145206093	63	8277										
FBN2	2201	broad.mit.edu	37	chr5	127638767	127638767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atttccacatggatgccgctCgcactcatcaacatctataa	5	13	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:127638767C>T	uc003kuu.2	-	46	6254	c.5815G>A	c.(5815-5817)GAG>AAG	p.E1939K		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1939	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGATGCCGCTCGCACTCATCA	0.348													0	0	0	0.012213	0	31	6										T	127638767	C	T	127638767	3	4	31	1	0	0	0	0	1	0	0	0	5703	893	31	1	3003	1	FBN2	5	127638767	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	91929600	127638767	53276493	64	8278										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139889761	139889761	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cacctcttatgtcagcatttCgcaaggtaatttgatatggg	9	8	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:139889761C>T	uc003lfs.1	+	22	4223	c.4099C>T	c.(4099-4101)CGC>TGC	p.R1367C	ANKHD1_uc003lfq.1_Missense_Mutation_p.R1386C|ANKHD1_uc003lfr.2_Missense_Mutation_p.R1367C|ANKHD1_uc003lft.1_Missense_Mutation_p.R578C|ANKHD1_uc003lfu.1_Missense_Mutation_p.R847C|ANKHD1_uc003lfv.1_Missense_Mutation_p.R444C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R106C|ANKHD1_uc003lfw.2_Missense_Mutation_p.R5C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1367						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAGCATTTCGCAAGGTAAT	0.388													0	0	0	0.014758	0	4	23										T	139889761	C	T	139889761	3	4	31	1	0	0	0	0	1	0	0	0	629	884	31	1	4185	1	ANKHD1-EIF4EBP3	5	139889761	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	12250994	139889761	41025499	65	8279										
DCTN4	51164	broad.mit.edu	37	chr5	150099298	150099298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cttcatgtagcgaaggttggGaattgacatgattctcactt	10	7	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:150099298G>A	uc003lsv.2	-	10	1045	c.943C>T	c.(943-945)CCC>TCC	p.P315S	DCTN4_uc003lsu.2_Missense_Mutation_p.P258S|DCTN4_uc010jhi.2_Missense_Mutation_p.P322S	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	315						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGAAGGTTGGGAATTGACATG	0.333													0	0	0	0.008871	0	19	2										A	150099298	G	A	150099298	3	1	31	1	0	0	0	0	1	0	0	0	4309	1174	41	1	455	1	DCTN4	5	150099298	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	10209537	150099298	30815962	66	8280										
STK10	6793	broad.mit.edu	37	chr5	171472003	171472003	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atctcctgctcccgcttcttCtggttcagatcctcttccag	6	16	5	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:171472003C>G	uc003mbo.1	-	19	3090	c.2790G>C	c.(2788-2790)CAG>CAC	p.Q930H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	930	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCCGCTTCTTCTGGTTCAGAT	0.587													0	0	0	0.016723	0	13	35										G	171472003	C	G	171472003	3	3	31	1	0	0	0	0	1	0	0	0	15285	912	32	1	120	1	STK10	5	171472003	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	21372705	171472003	9443257	67	8281										
FGFR4	2264	broad.mit.edu	37	chr5	176523291	176523291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccctctctcccctccagggcCgcctgcctgtgaagtggatg	11	17	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:176523291C>T	uc003mfl.2	+	15	2115	c.1948C>T	c.(1948-1950)CGC>TGC	p.R650C	FGFR4_uc003mfm.2_Missense_Mutation_p.R650C|FGFR4_uc011dfu.1_Missense_Mutation_p.R582C|FGFR4_uc003mfo.2_Missense_Mutation_p.R610C	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	650	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCTCCAGGGCCGCCTGCCTGT	0.672										TSP Lung(9;0.080)			0	0	0	0.028581	0	13	42										T	176523291	C	T	176523291	3	4	31	1	0	0	0	0	1	0	0	0	5868	652	23	2	2072	2	FGFR4	5	176523291	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	5051288	176523291	4391969	68	8282										
ZBTB12	221527	broad.mit.edu	37	chr6	31868680	31868680	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agcctcactgaccccatcctCtttgaggcctattttgggct	8	14	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:31868680C>G	uc003nyd.1	-	2	579	c.403G>C	c.(403-405)GAG>CAG	p.E135Q	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCCCATCCTCTTTGAGGCCT	0.602													0	0	0	0.01892	0	22	48										G	31868680	C	G	31868680	3	3	31	1	0	0	0	0	1	0	0	0	17522	922	32	1	980	1	ZBTB12	6	31868680	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		31868680	139246387	69	8283										
SCUBE3	222663	broad.mit.edu	37	chr6	35207570	35207570	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	acaacgggggctgtgaccatAtttgccgcaacacagtgggc	13	11	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:35207570A>G	uc003okf.1	+	8	877	c.871A>G	c.(871-873)ATT>GTT	p.I291V	SCUBE3_uc003okg.1_Missense_Mutation_p.I290V|SCUBE3_uc003okh.1_Missense_Mutation_p.I178V	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	291	EGF-like 7; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CTGTGACCATATTTGCCGCAA	0.463													0	0	0	0.009096	0	3	75										G	35207570	A	G	35207570	3	3	31	1	0	0	0	0	1	0	0	0	13946	449	16	5	901	5	SCUBE3	6	35207570	Missense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	3338890	35207570	135907497	70	8284										
CDKN1A	1026	broad.mit.edu	37	chr6	36652011	36652012	+	Frame_Shift_Ins	INS	-	-	C													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcgggctgcatccaggaggINScccgtgagcgatggaacttc							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:36652011_36652012insC	uc003omm.3	+	2	255_256	c.133_134insC	c.(133-135)GCCfs	p.A45fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.A79fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.A45fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.A45fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	45					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						CATCCAGGAGGCCCGTGAGCGA	0.658									Multiple_Endocrine_Neoplasia_type_1									20	24	---	---								C	36652012	-	C	36652011	7	5	31	1	0	1	1	0	0	0	0	0	3158	1203	42	0	135	0	CDKN1A	6	36652011	Frame_Shift_Ins	INS	-	TCGA-CF-A3MG-01A-11D-A20D-08	1444441	36652011	134463056	71	8285										
CDK19	23097	broad.mit.edu	37	chr6	110943360	110943360	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gggtatggaatctggcagccGgcaaatacactaaaaatcat	10	8	2	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:110943360G>A	uc003puh.1	-	11	1114	c.1041C>T	c.(1039-1041)GCC>GCT	p.A347A	CDK19_uc003pui.1_Silent_p.A287A|CDK19_uc011eax.1_Silent_p.A223A	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	347							ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TCTGGCAGCCGGCAAATACAC	0.318													0	0	0	0.009096	0	3	73										A	110943360	G	A	110943360	2	1	31	1	0	0	0	0	0	0	0	1	3135	1103	39	2		2	CDK19	6	110943360	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	74291349	110943360	60171707	72	8286										
LATS1	9113	broad.mit.edu	37	chr6	150001017	150001017	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atgagtttacttaccactctGatagtacttagaatcgtgtg	8	7	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:150001017G>C	uc003qmu.1	-	5	3135	c.2587C>G	c.(2587-2589)CAG>GAG	p.Q863E	LATS1_uc010kif.1_Missense_Mutation_p.Q758E|LATS1_uc003qmv.1_Missense_Mutation_p.Q863E	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	863	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TTACCACTCTGATAGTACTTA	0.313													0	0	0	0.024245	0	15	21										C	150001017	G	C	150001017	3	2	31	1	0	0	0	0	1	0	0	0	8646	1299	45	1	821	1	LATS1	6	150001017	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	39057657	150001017	21114050	73	8287										
SYNE1	23345	broad.mit.edu	37	chr6	152461088	152461088	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aggcaaggggcagctaccttGagctttttgatctggagctc	13	9	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:152461088G>C	uc010kiw.2	-	140	26057	c.25455C>G	c.(25453-25455)CTC>CTG	p.L8485L	SYNE1_uc010kiv.2_Silent_p.L3009L|SYNE1_uc003qos.3_Silent_p.L3009L|SYNE1_uc003qot.3_Silent_p.L8437L|SYNE1_uc003qou.3_Silent_p.L8485L|SYNE1_uc003qop.3_Silent_p.L670L|SYNE1_uc011eez.1_Silent_p.L687L|SYNE1_uc003qoq.3_Silent_p.L687L|SYNE1_uc003qor.3_Silent_p.L1408L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8485	Cytoplasmic (Potential).|Spectrin 31.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGCTACCTTGAGCTTTTTGA	0.587										HNSCC(10;0.0054)			0	0	0	0.004482	0	9	45										C	152461088	G	C	152461088	2	2	31	1	0	0	0	0	0	0	0	1	15442	1277	45	1		1	SYNE1	6	152461088	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	2460071	152461088	18653979	74	8288										
GPR141	353345	broad.mit.edu	37	chr7	37780343	37780343	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctggtcaccagatacctcatCttcttcaagtgcaaagacaa	6	12	5	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:37780343C>G	uc003tfm.1	+	1	348	c.348C>G	c.(346-348)ATC>ATG	p.I116M	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	116	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						GATACCTCATCTTCTTCAAGT	0.493													0	0	0	0.024245	0	13	91										G	37780343	C	G	37780343	3	3	31	1	0	0	0	0	1	0	0	0	6649	903	32	1	350	1	GPR141	7	37780343	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		37780343	121358320	75	8289										
LIMK1	3984	broad.mit.edu	37	chr7	73513430	73513430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cctgcctgactcccctggctCccacctgccccacaccgtca	6	23	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:73513430C>T	uc003uaa.1	+	5	635	c.470C>T	c.(469-471)TCC>TTC	p.S157F	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.S123F|LIMK1_uc003uac.1_5'UTR	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	157					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				TCCCCTGGCTCCCACCTGCCC	0.647													0	0	0	0.01441	0	53	226										T	73513430	C	T	73513430	3	4	31	1	0	0	0	0	1	0	0	0	8801	855	30	1	488	1	LIMK1	7	73513430	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	35733087	73513430	85625233	76	8290										
FAM71F2	346653	broad.mit.edu	37	chr7	128317840	128317840	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	actcactgcctggtgcccaaGatgcccaccaactccacaga	7	17	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:128317840G>A	uc003vnk.3	+	3	694	c.588G>A	c.(586-588)AAG>AAA	p.K196K	FAM71F2_uc010llm.1_Silent_p.K187K|FAM71F2_uc003vnl.2_RNA|FAM71F2_uc010lln.1_RNA	NM_001012454	NP_001012457	Q6NXP2	F71F2_HUMAN	hypothetical protein LOC346653 isoform a	196											0						TGGTGCCCAAGATGCCCACCA	0.453													0	0	0	0.01892	0	23	21										A	128317840	G	A	128317840	2	1	31	1	0	0	0	0	0	0	0	1	5613	933	33	1		1	FAM71F2	7	128317840	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	54804410	128317840	30820823	77	8291										
TRPV5	56302	broad.mit.edu	37	chr7	142626153	142626153	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cctgatgtcagctccatgctCaatgagcagccgcacgatct	9	14	3	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:142626153C>A	uc003wby.1	-	5	814	c.550G>T	c.(550-552)GAG>TAG	p.E184*	TRPV5_uc003wbz.2_Nonsense_Mutation_p.E184*	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	184	ANK 4.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GCTCCATGCTCAATGAGCAGC	0.612													1	0	2.23348e-06	0.028581	2.33399e-06	12	30										A	142626153	C	A	142626153	4	1	31	1	0	0	0	0	0	1	0	0	16596	835	29	3	1683	3	TRPV5	7	142626153	Nonsense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	14308313	142626153	16512510	78	8292										
PPP1R3B	79660	broad.mit.edu	37	chr8	8998846	8998846	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cagaacaaagctctcgctctCtgctgtcgtcaagctcacaa	7	14	4	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:8998846C>G	uc003wsn.3	-	2	481	c.316G>C	c.(316-318)GAG>CAG	p.E106Q	PPP1R3B_uc003wso.3_Missense_Mutation_p.E105Q	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	106					glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		CTCTCGCTCTCTGCTGTCGTC	0.483													0	0	0	0.012213	0	33	58										G	8998846	C	G	8998846	3	3	31	1	0	0	0	0	1	0	0	0	12372	922	32	1	545	1	PPP1R3B	8	8998846	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		8998846	137365176	79	8293										
BMP1	649	broad.mit.edu	37	chr8	22033756	22033756	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agatcccgtagccggcgggcGgcgacgtcccgaccagagcg	16	15	0	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:22033756G>A	uc003xbg.2	+	3	607	c.363G>A	c.(361-363)GCG>GCA	p.A121A	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Silent_p.A121A|BMP1_uc003xbb.2_Silent_p.A121A|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_5'UTR|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_5'UTR|BMP1_uc011kzc.1_5'UTR|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	121	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCCGGCGGGCGGCGACGTCCC	0.622													0	0	0	0.01892	0	22	41										A	22033756	G	A	22033756	2	1	31	1	0	0	0	0	0	0	0	1	1456	1103	39	2		2	BMP1	8	22033756	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	13034910	22033756	124330266	80	8294										
PPP3CC	5533	broad.mit.edu	37	chr8	22332514	22332514	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttactttcaaggaagtatttGagaatgggaaacctaaagtt	9	4	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:22332514G>C	uc003xbs.2	+	2	424	c.97G>C	c.(97-99)GAG>CAG	p.E33Q	PPP3CC_uc003xbr.1_Missense_Mutation_p.E33Q|PPP3CC_uc011kzi.1_Missense_Mutation_p.E33Q|PPP3CC_uc003xbt.2_Missense_Mutation_p.E33Q	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma	33					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		GGAAGTATTTGAGAATGGGAA	0.338													0	0	0	0.008291	0	10	20										C	22332514	G	C	22332514	3	2	31	1	0	0	0	0	1	0	0	0	12399	1291	45	1	103	1	PPP3CC	8	22332514	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	298758	22332514	124031508	81	8295										
LSM1	27257	broad.mit.edu	37	chr8	38021254	38021254	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tccttcagggcctgcactttCaacttctctgcttccagctt	6	15	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:38021254C>T	uc003xkw.2	-	4	524	c.336G>A	c.(334-336)TTG>TTA	p.L112L	LSM1_uc003xkx.2_RNA	NM_014462	NP_055277	O15116	LSM1_HUMAN	Lsm1 protein	112					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|mRNA processing|RNA splicing, via transesterification reactions	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0	Colorectal(12;0.000442)					CCTGCACTTTCAACTTCTCTG	0.478													0	0	0	0.006214	0	9	31										T	38021254	C	T	38021254	2	4	31	1	0	0	0	0	0	0	0	1	9050	825	29	1		1	LSM1	8	38021254	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	15688740	38021254	108342768	82	8296										
ST18	9705	broad.mit.edu	37	chr8	53084772	53084772	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	taaaacatactttgggactcTaggtggtttggtttcttctg	10	6	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:53084772T>C	uc003xqz.2	-	5	805	c.649A>G	c.(649-651)AGA>GGA	p.R217G	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.R182G|ST18_uc011lds.1_Missense_Mutation_p.R122G|ST18_uc003xra.2_Missense_Mutation_p.R217G|ST18_uc003xrb.2_Missense_Mutation_p.R217G	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	217						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTTGGGACTCTAGGTGGTTTG	0.413													0	0	0	0.01892	0	24	24										C	53084772	T	C	53084772	3	2	31	1	0	0	0	0	1	0	0	0	15211	1530	53	5	2562	5	ST18	8	53084772	Missense_Mutation	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	15063518	53084772	93279250	83	8297										
BHLHE22	27319	broad.mit.edu	37	chr8	65493618	65493620	+	In_Frame_Del	DEL	GGC	GGC	-													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gcggcggcagcgcgggaagtGgcggcggcggcggcggcggg							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:65493618_65493620delGGC	uc003xvi.2	+	1	805_807	c.271_273delGGC	c.(271-273)GGCdel	p.G97del	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	97	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						cgcgggaagtggcggcggcggcg	0.586																		2	4	---	---								-	65493620	GGC	-	65493618	7	5	31	1	0	1	0	1	0	0	0	0	1421	1348	47	0	273	0	BHLHE22	8	65493618	In_Frame_Del	DEL	GGC	TCGA-CF-A3MG-01A-11D-A20D-08	12408846	65493618	80870404	84	8298										
RIMS2	9699	broad.mit.edu	37	chr8	104933968	104933968	+	Frame_Shift_Del	DEL	G	G	-													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttacctctcccatgagtcctGgaatgttgagggatgtccca							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:104933968delG	uc003yls.2	+	8	1727	c.1486delG	c.(1486-1488)GGAfs	p.G496fs	RIMS2_uc003ylp.2_Frame_Shift_Del_p.G718fs|RIMS2_uc003ylw.2_Frame_Shift_Del_p.G526fs|RIMS2_uc003ylq.2_Frame_Shift_Del_p.G526fs|RIMS2_uc003ylr.2_Frame_Shift_Del_p.G573fs|RIMS2_uc003ylt.2_Frame_Shift_Del_p.G119fs|RIMS2_uc003ylv.1_Frame_Shift_Del_p.G109fs	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	796					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CATGAGTCCTGGAATGTTGAG	0.348										HNSCC(12;0.0054)								30	54	---	---								-	104933968	G	-	104933968	7	5	31	1	0	1	0	1	0	0	0	0	13368	1349	47	0	2316	0	RIMS2	8	104933968	Frame_Shift_Del	DEL	G	TCGA-CF-A3MG-01A-11D-A20D-08	39440350	104933968	41430054	85	8299										
NOL6	65083	broad.mit.edu	37	chr9	33464905	33464905	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcattattgaggttgacaaaGagggggttgttcttccaatc	11	6	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:33464905G>C	uc003zsz.2	-	21	2852	c.2751C>G	c.(2749-2751)CTC>CTG	p.L917L	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'UTR|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Silent_p.L914L|NOL6_uc011lob.1_Silent_p.L865L|NOL6_uc003ztb.1_Silent_p.L917L	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	917					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTTGACAAAGAGGGGGTTGT	0.483													0	0	0	0.028581	0	13	27										C	33464905	G	C	33464905	2	2	31	1	0	0	0	0	0	0	0	1	10525	929	33	1		1	NOL6	9	33464905	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		33464905	107748526	86	8300										
NR4A3	8013	broad.mit.edu	37	chr9	102590691	102590691	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccattcctccagcctccagcCcggaggacgaggtgctgccc	11	18	0	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:102590691C>A	uc004baf.1	+	3	1096	c.367C>A	c.(367-369)CCG>ACG	p.P123T	NR4A3_uc004bae.2_Missense_Mutation_p.P123T|NR4A3_uc004bag.1_Missense_Mutation_p.P123T|NR4A3_uc004bai.2_Missense_Mutation_p.P134T	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	123					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AGCCTCCAGCCCGGAGGACGA	0.537			T	EWSR1	extraskeletal myxoid chondrosarcoma								1	0	1.52319e-26	0.033182	1.66673e-26	38	0										A	102590691	C	A	102590691	3	1	31	1	0	0	0	0	1	0	0	0	10634	623	22	4	406	4	NR4A3	9	102590691	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	69125786	102590691	38622740	87	8301										
ZBTB26	57684	broad.mit.edu	37	chr9	125681289	125681289	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcgatgaaggttgcctttctGagtgaaagtcttgccgcaga	12	8	2	4			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:125681289G>A	uc004bnj.2	-	2	1137	c.925C>T	c.(925-927)CAG>TAG	p.Q309*	ZBTB26_uc004bnk.2_Nonsense_Mutation_p.Q309*	NM_020924	NP_065975	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	309	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGCCTTTCTGAGTGAAAGTC	0.443													0	0	0	0.016522	0	24	35										A	125681289	G	A	125681289	4	1	31	1	0	0	0	0	0	1	0	0	17530	1299	45	1	404	1	ZBTB26	9	125681289	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	23090598	125681289	15532142	88	8302										
STRBP	55342	broad.mit.edu	37	chr9	125898322	125898322	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tttaatgtttactcatacctGagggataatcttctttttct	5	7	4	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:125898322G>A	uc004bns.2	-	16	2201	c.1771C>T	c.(1771-1773)CAG>TAG	p.Q591*	STRBP_uc004bnt.2_Nonsense_Mutation_p.Q409*|STRBP_uc004bnu.2_Nonsense_Mutation_p.Q577*|STRBP_uc004bnv.2_Nonsense_Mutation_p.Q591*|STRBP_uc004bnr.2_Nonsense_Mutation_p.Q150*	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	591					multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						ACTCATACCTGAGGGATAATC	0.378													0	0	0	0.004482	0	8	20										A	125898322	G	A	125898322	4	1	31	1	0	0	0	0	0	1	0	0	15326	1299	45	1	263	1	STRBP	9	125898322	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	217033	125898322	15315109	89	8303										
TSC1	7248	broad.mit.edu	37	chr9	135797300	135797300	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagggtacattccataaaggCgatgaaagagtgcgtacaca	11	7	0	2	rs118203401		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:135797300C>G	uc004cca.2	-	7	803	c.569G>C	c.(568-570)CGC>CCC	p.R190P	TSC1_uc004ccb.3_Missense_Mutation_p.R190P|TSC1_uc011mcq.1_Missense_Mutation_p.R139P|TSC1_uc011mcr.1_Missense_Mutation_p.R69P|TSC1_uc011mcs.1_Missense_Mutation_p.R69P|TSC1_uc004ccc.1_Missense_Mutation_p.R190P|TSC1_uc004ccd.2_Missense_Mutation_p.R190P|TSC1_uc004cce.1_Missense_Mutation_p.R190P	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	190			R -> S.		activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TCCATAAAGGCGATGAAAGAG	0.458			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.021022	0	32	7										G	135797300	C	G	135797300	3	3	31	1	0	0	0	0	1	0	0	0	16602	768	27	4	2993	4	TSC1	9	135797300	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	9898978	135797300	5416131	90	8304										
ADARB2	105	broad.mit.edu	37	chr10	1405390	1405390	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cacggccatcacgaagctccGcgcgcgccgctcggccggtt	13	18	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:1405390G>A	uc009xhq.2	-	3	1284	c.910C>T	c.(910-912)CGG>TGG	p.R304W		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	304	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		ACGAAGCTCCGCGCGCGCCGC	0.672													0	0	0	0.00308	0	7	7										A	1405390	G	A	1405390	3	1	31	1	0	0	0	0	1	0	0	0	283	1086	38	2	1341	2	ADARB2	10	1405390	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		1405390	134129357	91	8305										
MYO3A	53904	broad.mit.edu	37	chr10	26462805	26462805	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gaagaggttaagcaagaattCtaccttgtagggccagaagt	12	6	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:26462805C>T	uc001isn.2	+	30	3972	c.3612C>T	c.(3610-3612)TTC>TTT	p.F1204F	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1204					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGCAAGAATTCTACCTTGTAG	0.423													0	0	0	0.004482	0	9	47										T	26462805	C	T	26462805	2	4	31	1	0	0	0	0	0	0	0	1	10076	912	32	1		1	MYO3A	10	26462805	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	25057415	26462805	109071942	92	8306										
C10orf58	84293	broad.mit.edu	37	chr10	82187195	82187195	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aacggaggcttctctggaaaCctggaaggagaaggcttcat	13	8	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:82187195C>G	uc001kcc.3	+	5	679	c.519C>G	c.(517-519)AAC>AAG	p.N173K	C10orf58_uc001kcd.3_Missense_Mutation_p.N162K|C10orf58_uc001kce.3_Missense_Mutation_p.N173K|C10orf58_uc001kcf.3_Missense_Mutation_p.N173K	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	173						extracellular region					0			Colorectal(32;0.229)			TCTCTGGAAACCTGGAAGGAG	0.502													0	0	0	0.023175	0	38	27										G	82187195	C	G	82187195	3	3	31	1	0	0	0	0	1	0	0	0	1610	506	18	4	533	4	C10orf58	10	82187195	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	55724390	82187195	53347552	93	8307										
MYOF	26509	broad.mit.edu	37	chr10	95072942	95072942	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gattttgcaggaatgatcgtGtgacgcaagtcaagttctag	12	6	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:95072942G>A	uc001kin.2	-	51	5847	c.5724C>T	c.(5722-5724)CAC>CAT	p.H1908H	MYOF_uc001kio.2_Silent_p.H1895H|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1908	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GAATGATCGTGTGACGCAAGT	0.458													0	0	0	0.037714	0	30	53										A	95072942	G	A	95072942	2	1	31	1	0	0	0	0	0	0	0	1	10089	1368	48	2		2	MYOF	10	95072942	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	12885747	95072942	40461805	94	8308										
SORCS3	22986	broad.mit.edu	37	chr10	106916944	106916944	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	caaacaagaaggtggacgacCaggtgaagacatacatcact	10	9	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:106916944C>T	uc001kyi.1	+	10	1758	c.1531C>T	c.(1531-1533)CAG>TAG	p.Q511*		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	511	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTGGACGACCAGGTGAAGAC	0.522													0	0	0	0.027356	0	26	35										T	106916944	C	T	106916944	4	4	31	1	0	0	0	0	0	1	0	0	14932	595	21	2	1569	2	SORCS3	10	106916944	Nonsense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	11844002	106916944	28617803	95	8309										
B4GALNT4	338707	broad.mit.edu	37	chr11	380870	380870	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cctttttgggatctacaagtCggactttgaccgggttggag	13	8	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:380870C>G	uc001lpb.2	+	19	2924	c.2915C>G	c.(2914-2916)TCG>TGG	p.S972W		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	972	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCTACAAGTCGGACTTTGAC	0.612													0	0	0	0.004482	0	9	19										G	380870	C	G	380870	3	3	31	1	0	0	0	0	1	0	0	0	1269	893	31	1	2989	1	B4GALNT4	11	380870	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		380870	134625646	96	8310										
CEND1	51286	broad.mit.edu	37	chr11	788279	788279	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agcctcatcttcctccgcccCgtccccaggacccttgggct	8	20	2	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:788279C>T	uc001lrh.1	-	2	477	c.298G>A	c.(298-300)GGG>AGG	p.G100R		NM_016564	NP_057648	Q8N111	CEND_HUMAN	cell cycle exit and neuronal differentiation 1	100	Cytoplasmic (Potential).					integral to membrane					0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCCTCCGCCCCGTCCCCAGGA	0.692													0	0	0	0.021553	0	6	8										T	788279	C	T	788279	3	4	31	1	0	0	0	0	1	0	0	0	3225	652	23	2	155	2	CEND1	11	788279	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	407409	788279	134218237	97	8311										
OR51S1	119692	broad.mit.edu	37	chr11	4869844	4869844	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtaggctgcaccccaagcttCtgggcaggccaaacgagcca	12	14	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:4869844C>G	uc010qyo.1	-	1	595	c.595G>C	c.(595-597)GAA>CAA	p.E199Q		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCCAAGCTTCTGGGCAGGCC	0.542													0	0	0	0.010818	0	29	36										G	4869844	C	G	4869844	3	3	31	1	0	0	0	0	1	0	0	0	11105	922	32	1	379	1	OR51S1	11	4869844	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	4081565	4869844	130136672	98	8312										
PIK3C2A	5286	broad.mit.edu	37	chr11	17143877	17143877	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aaatgcaggagaaggaaaatCaacctttaaaatttaacaga	7	5	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:17143877C>T	uc001mmq.3	-	14	2581	c.2515G>A	c.(2515-2517)GAT>AAT	p.D839N	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.D459N|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	839					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GAAGGAAAATCAACCTTTAAA	0.303													0	0	0	0.02938	0	6	31										T	17143877	C	T	17143877	3	4	31	1	0	0	0	0	1	0	0	0	11909	826	29	1	2621	1	PIK3C2A	11	17143877	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	12274033	17143877	117862639	99	8313										
MYOD1	4654	broad.mit.edu	37	chr11	17741681	17741681	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gcaaggccgccaccatgcgcGagcggcgccgcctgagcaaa	14	16	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:17741681G>C	uc001mni.2	+	1	572	c.352G>C	c.(352-354)GAG>CAG	p.E118Q		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	118	Basic motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						CACCATGCGCGAGCGGCGCCG	0.662													0	0	0	0.004672	0	3	5										C	17741681	G	C	17741681	3	2	31	1	0	0	0	0	1	0	0	0	10088	1059	37	1	354	1	MYOD1	11	17741681	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	597804	17741681	117264835	100	8314										
OR8J3	81168	broad.mit.edu	37	chr11	55904466	55904466	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	accgtgactgctatcatatgCgaagcgcaggtggaaaaggc	13	9	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:55904466C>A	uc010riz.1	-	1	729	c.729G>T	c.(727-729)TCG>TCT	p.S243S		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CTATCATATGCGAAGCGCAGG	0.403													1	0	1.99824e-07	0.0333	2.10925e-07	17	18										A	55904466	C	A	55904466	2	1	31	1	0	0	0	0	0	0	0	1	11242	755	27	4		4	OR8J3	11	55904466	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	38162785	55904466	79102050	101	8315										
OSBP	5007	broad.mit.edu	37	chr11	59376031	59376031	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tttgatcttttcattgctctCagcaggcaacttcagggact	8	10	4	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:59376031C>T	uc001noc.1	-	3	1228	c.748G>A	c.(748-750)GAG>AAG	p.E250K		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	250					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCATTGCTCTCAGCAGGCAAC	0.488													0	0	0	0.023175	0	38	45										T	59376031	C	T	59376031	3	4	31	1	0	0	0	0	1	0	0	0	11273	835	29	1	1723	1	OSBP	11	59376031	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	3471565	59376031	75630485	102	8316										
CHRM1	1128	broad.mit.edu	37	chr11	62677566	62677566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gcttctggcccttgccagctCgatcacgccctttcttagtc	8	16	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:62677566C>T	uc001nwi.2	-	2	1408	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q		NM_000738	NP_000729	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	336	Cytoplasmic (Potential).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding				0					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	CTTGCCAGCTCGATCACGCCC	0.627													0	0	0	0.016723	0	12	15										T	62677566	C	T	62677566	3	4	31	1	0	0	0	0	1	0	0	0	3376	884	31	1	379	1	CHRM1	11	62677566	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	3301535	62677566	72328950	103	8317										
ANO1	55107	broad.mit.edu	37	chr11	70007754	70007754	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	caaagacggagaaaagctttGaggagaggctgatcttcaag	13	6	2	5			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:70007754G>C	uc001opj.2	+	18	2112	c.1807G>C	c.(1807-1809)GAG>CAG	p.E603Q	ANO1_uc001opk.1_Missense_Mutation_p.E545Q|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.E312Q	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	603	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GAAAAGCTTTGAGGAGAGGCT	0.537													0	0	0	0.034045	0	24	93										C	70007754	G	C	70007754	3	2	31	1	0	0	0	0	1	0	0	0	695	1291	45	1	1877	1	ANO1	11	70007754	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	7330188	70007754	64998762	104	8318										
PHOX2A	401	broad.mit.edu	37	chr11	71950871	71950871	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccggagaagggcccggggccGgactccgccggctgccaagc	17	16	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:71950871G>A	uc001osh.3	-	3	949	c.777C>T	c.(775-777)TCC>TCT	p.S259S		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	259					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCGGGGCCGGACTCCGCCG	0.726													0	0	0	0.010729	0	11	2										A	71950871	G	A	71950871	2	1	31	1	0	0	0	0	0	0	0	1	11858	1103	39	2		2	PHOX2A	11	71950871	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1943117	71950871	63055645	105	8319										
KCNA6	3742	broad.mit.edu	37	chr12	4920778	4920778	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcgggcctatgcagagaaaaGaatgctcacggaggtctgac	13	9	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:4920778G>C	uc001qng.2	+	1	2437	c.1571G>C	c.(1570-1572)AGA>ACA	p.R524T		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	524						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						GCAGAGAAAAGAATGCTCACG	0.562										HNSCC(72;0.22)			0	0	0	0.014323	0	20	66										C	4920778	G	C	4920778	3	2	31	1	0	0	0	0	1	0	0	0	8007	942	33	1	1573	1	KCNA6	12	4920778	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		4920778	128931117	106	8320										
PLEKHA5	54477	broad.mit.edu	37	chr12	19473505	19473505	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttttcttatagctgtcacaaGatgaaggtagaggcacatta	9	6	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:19473505G>C	uc001reb.2	+	13	1941	c.1855G>C	c.(1855-1857)GAT>CAT	p.D619H	PLEKHA5_uc010sie.1_Missense_Mutation_p.D722H|PLEKHA5_uc001rea.2_Missense_Mutation_p.D677H|PLEKHA5_uc009zin.2_Missense_Mutation_p.D377H|PLEKHA5_uc010sif.1_Missense_Mutation_p.D550H|PLEKHA5_uc010sig.1_Missense_Mutation_p.D538H|PLEKHA5_uc010sih.1_Missense_Mutation_p.D511H|PLEKHA5_uc001rec.1_Missense_Mutation_p.D365H|PLEKHA5_uc009zio.2_5'Flank	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	619							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GCTGTCACAAGATGAAGGTAG	0.229													0	0	0	0.016723	0	14	126										C	19473505	G	C	19473505	3	2	31	1	0	0	0	0	1	0	0	0	12059	942	33	1	2030	1	PLEKHA5	12	19473505	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	14552727	19473505	114378390	107	8321										
CCDC65	85478	broad.mit.edu	37	chr12	49315100	49315100	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagcagtacttggatggcatCtcagtgagtgacgaagtgct	13	7	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:49315100C>G	uc001rso.2	+	8	1556	c.1329C>G	c.(1327-1329)ATC>ATG	p.I443M		NM_033124	NP_149115	Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	443										ovary(1)|skin(1)	2						TGGATGGCATCTCAGTGAGTG	0.498													0	0	0	0.024245	0	14	49										G	49315100	C	G	49315100	3	3	31	1	0	0	0	0	1	0	0	0	2837	903	32	1	1359	1	CCDC65	12	49315100	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	29841595	49315100	84536795	108	8322										
SCN8A	6334	broad.mit.edu	37	chr12	52200276	52200276	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gttcatcttctccatttttgGgatgtccaattttgcatatg	7	8	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:52200276G>A	uc001ryw.2	+	27	5184	c.5006G>A	c.(5005-5007)GGG>GAG	p.G1669E		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1669	IV.|Helical; Name=S5 of repeat IV; (Potential).				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCCATTTTTGGGATGTCCAAT	0.458													0	0	0	0.010729	0	12	90										A	52200276	G	A	52200276	3	1	31	1	0	0	0	0	1	0	0	0	13924	1232	43	2	5108	2	SCN8A	12	52200276	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	2885176	52200276	81651619	109	8323										
SCN8A	6334	broad.mit.edu	37	chr12	52200727	52200727	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gatgccttggagcatcctctCcgagtgcccaagcccaatac	9	15	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:52200727C>T	uc001ryw.2	+	27	5635	c.5457C>T	c.(5455-5457)CTC>CTT	p.L1819L		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1819					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AGCATCCTCTCCGAGTGCCCA	0.527													0	0	0	0.030466	0	42	47										T	52200727	C	T	52200727	2	4	31	1	0	0	0	0	0	0	0	1	13924	842	30	1		1	SCN8A	12	52200727	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	451	52200727	81651168	110	8324										
MBD6	114785	broad.mit.edu	37	chr12	57918191	57918191	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtgcgagagggtgctgtgctCtacatcaggtacggatcttc	14	9	3	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:57918191C>G	uc001soj.1	+	3	329	c.105C>G	c.(103-105)CTC>CTG	p.L35L	MBD6_uc001sok.1_5'Flank|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	35	MBD.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						GTGCTGTGCTCTACATCAGGT	0.587													0	0	0	0.02938	0	6	41										G	57918191	C	G	57918191	2	3	31	1	0	0	0	0	0	0	0	1	9348	900	32	1		1	MBD6	12	57918191	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	5717464	57918191	75933704	111	8325										
CAND1	55832	broad.mit.edu	37	chr12	67703818	67703818	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttcttccacatctttacaatGaaacaaaagttagaaaggag	6	7	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:67703818G>T	uc001stn.2	+	12	3600	c.3163G>T	c.(3163-3165)GAA>TAA	p.E1055*	CAND1_uc001sto.2_Nonsense_Mutation_p.E565*	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	1055	HEAT 25.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCTTTACAATGAAACAAAAGT	0.348													1	0	1.67942e-08	0.006122	1.79081e-08	18	47										T	67703818	G	T	67703818	4	4	31	1	0	0	0	0	0	1	0	0	2615	1291	45	3	3209	3	CAND1	12	67703818	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	9785627	67703818	66148077	112	8326										
KIAA1033	23325	broad.mit.edu	37	chr12	105527601	105527601	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atggatgatgaaaatggaatCtattttgtctaaagagcaga	10	3	2	4			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:105527601C>G	uc001tld.2	+	14	1340	c.1253C>G	c.(1252-1254)TCT>TGT	p.S418C	KIAA1033_uc010swr.1_Missense_Mutation_p.S418C|KIAA1033_uc010sws.1_Missense_Mutation_p.S230C	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	418					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						AAAATGGAATCTATTTTGTCT	0.343													0	0	0	0.010504	0	22	49										G	105527601	C	G	105527601	3	3	31	1	0	0	0	0	1	0	0	0	8206	913	32	1	1307	1	KIAA1033	12	105527601	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	37823783	105527601	28324294	113	8327										
DDX54	79039	broad.mit.edu	37	chr12	113596723	113596723	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gcccttcttggagcgggcacCccggccgaaggcgccctgct	14	17	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:113596723C>G	uc001tup.2	-	20	2633	c.2605G>C	c.(2605-2607)GGT>CGT	p.G869R	CCDC42B_uc010sys.1_3'UTR|DDX54_uc001tuq.3_Missense_Mutation_p.G870R	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	869					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GAGCGGGCACCCCGGCCGAAG	0.642													0	0	0	0.004482	0	6	34										G	113596723	C	G	113596723	3	3	31	1	0	0	0	0	1	0	0	0	4372	623	22	4	44	4	DDX54	12	113596723	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	8069122	113596723	20255172	114	8328										
MLEC	9761	broad.mit.edu	37	chr12	121132930	121132930	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aatcccaaggtctgtgcactCtacatcatggctgggacagt	10	11	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:121132930C>G	uc001tyy.1	+	4	775	c.624C>G	c.(622-624)CTC>CTG	p.L208L		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	208	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						TCTGTGCACTCTACATCATGG	0.498													0	0	0	0.021523	0	27	231										G	121132930	C	G	121132930	2	3	31	1	0	0	0	0	0	0	0	1	9613	900	32	1		1	MLEC	12	121132930	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	7536207	121132930	12718965	115	8329										
RSRC2	65117	broad.mit.edu	37	chr12	123005942	123005942	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgttaattacctctttgcttCtgctccggctcctgtgtttt	7	11	2	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:123005942C>G	uc001ucr.2	-	3	343	c.197G>C	c.(196-198)AGA>ACA	p.R66T	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_5'UTR|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.E11Q|RSRC2_uc001ucu.2_Missense_Mutation_p.R66T	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	66	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		CTCTTTGCTTCTGCTCCGGCT	0.318													0	0	0	0.006122	0	16	32										G	123005942	C	G	123005942	3	3	31	1	0	0	0	0	1	0	0	0	13715	913	32	1	1173	1	RSRC2	12	123005942	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	1873012	123005942	10845953	116	8330										
GPR133	283383	broad.mit.edu	37	chr12	131490586	131490586	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gaacaacatctggcccgcccAcaccaagtgagtctcggggg	12	14	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:131490586A>C	uc001uit.3	+	12	1884	c.1325A>C	c.(1324-1326)CAC>CCC	p.H442P	GPR133_uc010tbm.1_Missense_Mutation_p.H474P	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	442	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGCCCGCCCACACCAAGTGA	0.647													0	0	0	0.01892	0	23	47										C	131490586	A	C	131490586	3	2	31	1	0	0	0	0	1	0	0	0	6643	159	6	5	1371	5	GPR133	12	131490586	Missense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08	8484644	131490586	2361309	117	8331										
PARP4	143	broad.mit.edu	37	chr13	25021310	25021310	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctcggagaacatagcctggtCatttggtcttctatctattt	8	9	4	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:25021310C>T	uc001upl.2	-	26	3235	c.3129G>A	c.(3127-3129)ATG>ATA	p.M1043I		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1043	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity	p.M1043I(1)		ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATAGCCTGGTCATTTGGTCTT	0.433													0	0	0	0.021553	0	5	41										T	25021310	C	T	25021310	3	4	31	1	0	0	0	0	1	0	0	0	11463	826	29	1	2081	1	PARP4	13	25021310	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		25021310	90148568	118	8332										
MTUS2	23281	broad.mit.edu	37	chr13	29600135	29600135	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccagcagcttttcaccaggtGacagtcatgtggcttttatt	9	10	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:29600135G>A	uc001usl.3	+	1	1388	c.1330G>A	c.(1330-1332)GAC>AAC	p.D444N		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	434						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TTCACCAGGTGACAGTCATGT	0.488													0	0	0	0.008291	0	9	44										A	29600135	G	A	29600135	3	1	31	1	0	0	0	0	1	0	0	0	9966	1290	45	1	1332	1	MTUS2	13	29600135	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	4578825	29600135	85569743	119	8333										
FOXO1	2308	broad.mit.edu	37	chr13	41133687	41133687	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gacacccagctatgtgtcgtTgtcttgacactgtgtgggaa	12	9	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:41133687T>C	uc001uxl.3	-	2	2326	c.1941A>G	c.(1939-1941)ACA>ACG	p.T647T	FOXO1_uc010acc.1_Silent_p.T462T	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	647					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TATGTGTCGTTGTCTTGACAC	0.428													0	0	0	0.01441	0	40	56										C	41133687	T	C	41133687	2	2	31	1	0	0	0	0	0	0	0	1	6023	1799	63	5		5	FOXO1	13	41133687	Silent	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	11533552	41133687	74036191	120	8334										
COG3	83548	broad.mit.edu	37	chr13	46039343	46039343	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agaacttgccggtgccagctGaggtgaggtgatgggcagga	18	7	0	4			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:46039343G>A	uc001vak.2	+	1	273	c.172G>A	c.(172-174)GAG>AAG	p.E58K	COG3_uc010tfu.1_RNA|COG3_uc001vai.2_Missense_Mutation_p.E58K|COG3_uc001vaj.1_Missense_Mutation_p.E58K|COG3_uc010tfv.1_5'UTR	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	58					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		GGTGCCAGCTGAGGTGAGGTG	0.692													0	0	0	0.0333	0	15	35										A	46039343	G	A	46039343	3	1	31	1	0	0	0	0	1	0	0	0	3659	1291	45	1	174	1	COG3	13	46039343	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	4905656	46039343	69130535	121	8335										
DCT	1638	broad.mit.edu	37	chr13	95114290	95114290	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctgaaggtagagttctggaaGaagggaggattgtcaaactt	14	4	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:95114290G>A	uc001vlv.3	-	5	1444	c.1017C>T	c.(1015-1017)TTC>TTT	p.F339F	DCT_uc010afh.2_Silent_p.F339F	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	339	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AGTTCTGGAAGAAGGGAGGAT	0.448													0	0	0	0.010729	0	12	37										A	95114290	G	A	95114290	2	1	31	1	0	0	0	0	0	0	0	1	4304	933	33	1		1	DCT	13	95114290	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	49074947	95114290	20055588	122	8336										
ITGBL1	9358	broad.mit.edu	37	chr13	102106412	102106412	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcccctgtgtgagtgccatGagtgggtgtgcgagacctac	16	10	0	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:102106412G>A	uc001vpb.2	+	2	496	c.277G>A	c.(277-279)GAG>AAG	p.E93K	ITGBL1_uc010agb.2_Missense_Mutation_p.E93K|ITGBL1_uc001vpc.3_Intron	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	93	I.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAGTGCCATGAGTGGGTGTG	0.667													0	0	0	0.02938	0	4	10										A	102106412	G	A	102106412	3	1	31	1	0	0	0	0	1	0	0	0	7902	1291	45	1	283	1	ITGBL1	13	102106412	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	6992122	102106412	13063466	123	8337										
C13orf28	122258	broad.mit.edu	37	chr13	113052394	113052394	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtccaggagattttagatctGaataaaacaacaccgagcga	9	8	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:113052394G>A	uc001vsd.1	+	3	214	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	61						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					TTTTAGATCTGAATAAAACAA	0.473													0	0	0	0.012213	0	29	100										A	113052394	G	A	113052394	2	1	31	1	0	0	0	0	0	0	0	1	1724	1277	45	1		1	C13orf28	13	113052394	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	10945982	113052394	2117484	124	8338										
RALGAPA1	253959	broad.mit.edu	37	chr14	36064860	36064860	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttttttggtcaaagaatcatCagaatcagaaggcattcttg	8	6	5	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:36064860C>G	uc001wti.2	-	36	6062	c.5671G>C	c.(5671-5673)GAT>CAT	p.D1891H	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.D1891H|RALGAPA1_uc010tpv.1_Missense_Mutation_p.D1904H|RALGAPA1_uc010tpw.1_Missense_Mutation_p.D1938H	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1891	Minimal domain that binds to TCF3/E12 (By similarity).|Rap-GAP.				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AAAGAATCATCAGAATCAGAA	0.338													0	0	0	0.004482	0	6	59										G	36064860	C	G	36064860	3	3	31	1	0	0	0	0	1	0	0	0	13013	826	29	1	612	1	RALGAPA1	14	36064860	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		36064860	71284680	125	8339										
PCNX	22990	broad.mit.edu	37	chr14	71443817	71443817	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	accaccatgttgatcagtctCtgtccagcgcctgtgacaca	8	14	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:71443817C>T	uc001xmo.2	+	6	1209	c.763C>T	c.(763-765)CTG>TTG	p.L255L	PCNX_uc001xmn.3_Silent_p.L255L|PCNX_uc010are.1_Silent_p.L255L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	255						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGATCAGTCTCTGTCCAGCGC	0.502													0	0	0	0.006214	0	10	23										T	71443817	C	T	71443817	2	4	31	1	0	0	0	0	0	0	0	1	11591	912	32	1		1	PCNX	14	71443817	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	35378957	71443817	35905723	126	8340										
CHGA	1113	broad.mit.edu	37	chr14	93398816	93398818	+	In_Frame_Del	DEL	GAG	GAG	-													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aggagcactcccagcagaaaGaggaggaggaggagatggca							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:93398816_93398818delGAG	uc001ybc.3	+	7	1170_1172	c.910_912delGAG	c.(910-912)GAGdel	p.E308del	CHGA_uc010aum.2_RNA|CHGA_uc001ybd.3_In_Frame_Del_p.E157del	NM_001275	NP_001266	P10645	CMGA_HUMAN	chromogranin A precursor	308					regulation of blood pressure	extracellular region|stored secretory granule				skin(2)	2		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		CCAGCAGAAAGAGGAGGAGGAGG	0.655																		2	4	---	---								-	93398818	GAG	-	93398816	7	5	31	1	0	1	0	1	0	0	0	0	3338	943	33	0	936	0	CHGA	14	93398816	In_Frame_Del	DEL	GAG	TCGA-CF-A3MG-01A-11D-A20D-08	21954999	93398816	13950724	127	8341										
CCNK	8812	broad.mit.edu	37	chr14	99967695	99967695	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttttgtccccatttctaggtGataaaaacaaaattcaaaag	5	7	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:99967695G>C	uc001ygi.3	+	6	650	c.520G>C	c.(520-522)GAT>CAT	p.D174H	CCNK_uc001ygg.3_Missense_Mutation_p.D174H	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	174					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				ATTTCTAGGTGATAAAAACAA	0.294													0	0	0	0.006214	0	9	15										C	99967695	G	C	99967695	3	2	31	1	0	0	0	0	1	0	0	0	2930	1290	45	1	538	1	CCNK	14	99967695	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	6568879	99967695	7381845	128	8342										
CYP46A1	10858	broad.mit.edu	37	chr14	100157446	100157446	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	taggacacctcccctgctttTggaaaaaggatgaggttggt	12	8	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:100157446T>C	uc001ygo.2	+	2	148	c.148T>C	c.(148-150)TGG>CGG	p.W50R	CYP46A1_uc001ygn.1_5'UTR	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	50					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCCCTGCTTTTGGAAAAAGGA	0.483													0	0	0	0.030466	0	38	58										C	100157446	T	C	100157446	3	2	31	1	0	0	0	0	1	0	0	0	4182	1812	63	5	154	5	CYP46A1	14	100157446	Missense_Mutation	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	189751	100157446	7192094	129	8343										
GABRB3	2562	broad.mit.edu	37	chr15	26792968	26792968	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	catagtacagccagtaaactAagttgaaaagagaaaaagtg	9	5	0	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:26792968A>T	uc001zaz.2	-	9	1536	c.1394T>A	c.(1393-1395)TTA>TAA	p.L465*	GABRB3_uc010uae.1_Nonsense_Mutation_p.L380*|GABRB3_uc001zba.2_Nonsense_Mutation_p.L465*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.L521*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	465	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCAGTAAACTAAGTTGAAAAG	0.353													0	0	0	0.014323	0	22	32										T	26792968	A	T	26792968	4	4	31	1	0	0	0	0	0	1	0	0	6168	372	13	5	31	5	GABRB3	15	26792968	Nonsense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08		26792968	75738424	130	8344										
UNC13C	440279	broad.mit.edu	37	chr15	54825189	54825189	+	Frame_Shift_Del	DEL	C	C	-													0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aatgagagcaaatggaaacaCcacatctaataagaacagtg							TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:54825189delC	uc002ack.2	+	24	5621	c.5621delC	c.(5620-5622)ACCfs	p.T1874fs		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1874					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATGGAAACACCACATCTAAT	0.313																		7	4	---	---								-	54825189	C	-	54825189	7	5	31	1	0	1	0	1	0	0	0	0	16983	507	18	0	5715	0	UNC13C	15	54825189	Frame_Shift_Del	DEL	C	TCGA-CF-A3MG-01A-11D-A20D-08	28032221	54825189	47706203	131	8345										
TM6SF1	53346	broad.mit.edu	37	chr15	83776474	83776474	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggggtcttcgtgctgtccctCtcggccatcccggtcaccta	11	16	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:83776474C>T	uc002bjp.2	+	1	151	c.42C>T	c.(40-42)CTC>CTT	p.L14L	TM6SF1_uc010bmq.2_Silent_p.L14L|TM6SF1_uc002bjq.2_Silent_p.L14L|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	14	Helical; (Potential).					integral to membrane				ovary(1)	1						TGCTGTCCCTCTCGGCCATCC	0.567													0	0	0	0.021553	0	6	12										T	83776474	C	T	83776474	2	4	31	1	0	0	0	0	0	0	0	1	15969	900	32	1		1	TM6SF1	15	83776474	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	28951285	83776474	18754918	132	8346										
MCTP2	55784	broad.mit.edu	37	chr15	94913372	94913372	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcattctacaagtgaaggtTttaaaggcagcagatctctt	10	7	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:94913372T>G	uc002btj.2	+	11	1610	c.1545T>G	c.(1543-1545)GTT>GTG	p.V515V	MCTP2_uc002bti.2_Silent_p.V515V|MCTP2_uc010boj.2_Silent_p.V244V|MCTP2_uc010bok.2_Silent_p.V515V|MCTP2_uc002btk.3_Silent_p.V103V|MCTP2_uc002btl.2_Silent_p.V103V	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	515	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAGTGAAGGTTTTAAAGGCAG	0.373													0	0	0	0.004482	0	7	26										G	94913372	T	G	94913372	2	3	31	1	0	0	0	0	0	0	0	1	9401	1828	64	5		5	MCTP2	15	94913372	Silent	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	11136898	94913372	7618020	133	8347										
STUB1	10273	broad.mit.edu	37	chr16	732417	732417	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cccctgacccaggaacagctCatccccaacttggctatgaa	7	16	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:732417C>T	uc002cit.2	+	7	1251	c.840C>T	c.(838-840)CTC>CTT	p.L280L	STUB1_uc002ciu.2_Silent_p.L208L|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	280	U-box.			L -> F (in Ref. 1; AAC18038).	cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				AGGAACAGCTCATCCCCAACT	0.587													0	0	0	0.008871	0	21	52										T	732417	C	T	732417	2	4	31	1	0	0	0	0	0	0	0	1	15334	813	29	1		1	STUB1	16	732417	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		732417	89622336	134	8348										
BFAR	51283	broad.mit.edu	37	chr16	14748942	14748942	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggttgcttttaactttgacaGaggaagaattttccaagacg	10	6	0	4			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:14748942G>A	uc002dco.2	+	5	939	c.658G>A	c.(658-660)GAG>AAG	p.E220K	BFAR_uc002dcp.2_Missense_Mutation_p.E95K|BFAR_uc010uzh.1_Missense_Mutation_p.E92K	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	220	Lumenal (Potential).|SAM.				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						AACTTTGACAGAGGAAGAATT	0.443													0	0	0	0.010504	0	19	101										A	14748942	G	A	14748942	3	1	31	1	0	0	0	0	1	0	0	0	1414	943	33	1	672	1	BFAR	16	14748942	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	14016525	14748942	75605811	135	8349										
CDH8	1006	broad.mit.edu	37	chr16	61851482	61851482	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cttcaagtaggtaagtcggtGaagagaagaccggaggctca	14	7	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:61851482G>A	uc002eog.1	-	7	1430	c.1178C>T	c.(1177-1179)TCA>TTA	p.S393L	CDH8_uc002eoh.2_Missense_Mutation_p.S162L	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	393	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTAAGTCGGTGAAGAGAAGAC	0.498													0	0	0	0.008871	0	19	44										A	61851482	G	A	61851482	3	1	31	1	0	0	0	0	1	0	0	0	3116	1294	45	1	1245	1	CDH8	16	61851482	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	47102540	61851482	28503271	136	8350										
DUS2L	54920	broad.mit.edu	37	chr16	68071989	68071989	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atcctggccccaatggttcgGgtagggactcttccaatgag	12	11	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:68071989G>T	uc002evi.2	+	3	212	c.63G>T	c.(61-63)CGG>CGT	p.R21R	DUS2L_uc002evj.2_Silent_p.R21R|DUS2L_uc010vkk.1_Silent_p.R21R|DUS2L_uc010cez.2_5'UTR	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	21					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		CAATGGTTCGGGTAGGGACTC	0.473													1	0	4.26978e-12	0.01892	4.64783e-12	20	36										T	68071989	G	T	68071989	2	4	31	1	0	0	0	0	0	0	0	1	4806	1219	43	4		4	DUS2L	16	68071989	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	6220507	68071989	22282764	137	8351										
ANKRD11	29123	broad.mit.edu	37	chr16	89351556	89351556	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gctttccgaagcgaacctctCtgccttttgtttctttcttt	6	12	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:89351556C>T	uc002fmx.1	-	9	1855	c.1394G>A	c.(1393-1395)AGA>AAA	p.R465K	ANKRD11_uc002fmy.1_Missense_Mutation_p.R465K|ANKRD11_uc002fnc.1_Missense_Mutation_p.R465K|ANKRD11_uc002fnb.1_Missense_Mutation_p.R422K	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	465						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCGAACCTCTCTGCCTtttgt	0.443													0	0	0	0.02938	0	7	26										T	89351556	C	T	89351556	3	4	31	1	0	0	0	0	1	0	0	0	639	913	32	1	6617	1	ANKRD11	16	89351556	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	21279567	89351556	1003197	138	8352										
VPS53	55275	broad.mit.edu	37	chr17	465901	465901	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcggcgcagctggggagcacGgcacccccttcatcagtgtt	13	14	2	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:465901G>A	uc002frn.2	-	14	1545	c.1398C>T	c.(1396-1398)GCC>GCT	p.A466A	VPS53_uc002frk.2_5'UTR|VPS53_uc010cjo.1_Silent_p.A466A|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Silent_p.A437A|VPS53_uc002fro.2_Silent_p.A268A|VPS53_uc010cjp.1_Silent_p.A189A	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	466				A -> T (in Ref. 2; AAK27973).	protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TGGGGAGCACGGCACCCCCTT	0.552													0	0	0	0.021523	0	23	5										A	465901	G	A	465901	2	1	31	1	0	0	0	0	0	0	0	1	17212	1103	39	2		2	VPS53	17	465901	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		465901	80729309	139	8353										
LLGL1	3996	broad.mit.edu	37	chr17	18137636	18137636	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tagcagcactgtggtcagctCacacagcgatggcagctatg	12	11	2	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:18137636C>T	uc002gsp.2	+	7	825	c.764C>T	c.(763-765)TCA>TTA	p.S255L		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	255	WD 5.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GTGGTCAGCTCACACAGCGAT	0.517													0	0	0	0.004482	0	9	4										T	18137636	C	T	18137636	3	4	31	1	0	0	0	0	1	0	0	0	8833	838	29	1	790	1	LLGL1	17	18137636	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	17671735	18137636	63057574	140	8354										
KRT37	8688	broad.mit.edu	37	chr17	39580632	39580632	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	actctgttggcgtgtgccacGttggccaagaggcacatgga	14	10	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:39580632G>A	uc002hwp.1	-	1	191	c.144C>T	c.(142-144)AAC>AAT	p.N48N	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	48	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CGTGTGCCACGTTGGCCAAGA	0.617													0	0	0	0.009096	0	4	92										A	39580632	G	A	39580632	2	1	31	1	0	0	0	0	0	0	0	1	8474	1136	40	2		2	KRT37	17	39580632	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	21442996	39580632	41614578	141	8355										
HDAC5	10014	broad.mit.edu	37	chr17	42165952	42165952	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	acccgtcactagtggggactGcccgtggagtggcactacgg	15	12	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:42165952G>A	uc002ifd.1	-	12	1613	c.1402C>T	c.(1402-1404)CAG>TAG	p.Q468*	HDAC5_uc002ife.1_Nonsense_Mutation_p.Q468*|HDAC5_uc002iff.1_Nonsense_Mutation_p.Q469*|HDAC5_uc010czp.1_Nonsense_Mutation_p.Q468*|HDAC5_uc002ifh.2_Nonsense_Mutation_p.Q468*	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	468					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		AGTGGGGACTGCCCGTGGAGT	0.652													0	0	0	0.009096	0	3	41										A	42165952	G	A	42165952	4	1	31	1	0	0	0	0	0	1	0	0	7010	1328	46	2	2030	2	HDAC5	17	42165952	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	2585320	42165952	39029258	142	8356										
TOB1	10140	broad.mit.edu	37	chr17	48940765	48940765	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tcaagccgaggttgatgggaGaagtacgtgcaaccttgttg	14	7	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:48940765G>A	uc002isw.2	-	1	649	c.614C>T	c.(613-615)TCT>TTT	p.S205F	TOB1_uc010wmy.1_Missense_Mutation_p.S205F|TOB1_uc010wmz.1_Missense_Mutation_p.S205F	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	205					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTTGATGGGAGAAGTACGTGC	0.473													0	0	0	0.020292	0	14	72										A	48940765	G	A	48940765	3	1	31	1	0	0	0	0	1	0	0	0	16344	942	33	1	427	1	TOB1	17	48940765	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	6774813	48940765	32254445	143	8357										
TOB1	10140	broad.mit.edu	37	chr17	48941123	48941123	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aacactaagatcctgtggcaGattgccacgaacatcatcaa	7	11	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:48941123G>A	uc002isw.2	-	1	291	c.256C>T	c.(256-258)CTG>TTG	p.L86L	TOB1_uc010wmy.1_Silent_p.L86L|TOB1_uc010wmz.1_Silent_p.L86L	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	86					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TCCTGTGGCAGATTGCCACGA	0.433													0	0	0	0.017118	0	33	90										A	48941123	G	A	48941123	2	1	31	1	0	0	0	0	0	0	0	1	16344	933	33	1		1	TOB1	17	48941123	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	358	48941123	32254087	144	8358										
SALL3	27164	broad.mit.edu	37	chr18	76753543	76753543	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cctggctggacagcaagcccGtgctgcccaccgtgcccacg	12	18	0	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr18:76753543G>A	uc002lmt.2	+	2	1552	c.1552G>A	c.(1552-1554)GTG>ATG	p.V518M	SALL3_uc010dra.2_Missense_Mutation_p.V125M	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCAAGCCCGTGCTGCCCAC	0.721													0	0	0	0.014758	0	4	7										A	76753543	G	A	76753543	3	1	31	1	0	0	0	0	1	0	0	0	13812	1145	40	2	1558	2	SALL3	18	76753543	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		76753543	1323705	145	8359										
ZNF208	7757	broad.mit.edu	37	chr19	22155504	22155504	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tttgccacattcttcacattTgtagggtttctctacagtat	6	9	3	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:22155504T>C	uc002nqp.2	-	5	2181	c.2032A>G	c.(2032-2034)AAA>GAA	p.K678E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTTCACATTTGTAGGGTTTC	0.368													0	0	0	0.004672	0	3	26										C	22155504	T	C	22155504	3	2	31	1	0	0	0	0	1	0	0	0	17763	1821	63	5	1514	5	ZNF208	19	22155504	Missense_Mutation	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08		22155504	36973479	146	8360										
ZNF829	374899	broad.mit.edu	37	chr19	37383084	37383084	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tttttaccagtgtgaatcctCtgatgtcgagtaacgagtga	10	7	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:37383084C>G	uc002ofa.1	-	6	971	c.609G>C	c.(607-609)CAG>CAC	p.Q203H	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	203	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGAATCCTCTGATGTCGAG	0.383													0	0	0	0.024245	0	14	43										G	37383084	C	G	37383084	3	3	31	1	0	0	0	0	1	0	0	0	18179	912	32	1	693	1	ZNF829	19	37383084	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	15227580	37383084	21745899	147	8361										
SPTBN4	57731	broad.mit.edu	37	chr19	41040194	41040194	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	acatggagagccagctgcaaGacgtggaccctggaggagac	15	10	0	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:41040194G>C	uc002ony.2	+	20	4389	c.4303G>C	c.(4303-4305)GAC>CAC	p.D1435H	SPTBN4_uc002onx.2_Missense_Mutation_p.D1435H|SPTBN4_uc002onz.2_Missense_Mutation_p.D1435H|SPTBN4_uc010egx.2_Missense_Mutation_p.D178H|SPTBN4_uc010egy.1_Missense_Mutation_p.D111H|SPTBN4_uc002ooa.2_Missense_Mutation_p.D111H|SPTBN4_uc010egz.1_Missense_Mutation_p.D111H	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1435	Spectrin 12.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGCTGCAAGACGTGGACCC	0.582													0	0	0	0.006214	0	8	46										C	41040194	G	C	41040194	3	2	31	1	0	0	0	0	1	0	0	0	15120	942	33	1	4377	1	SPTBN4	19	41040194	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	3657110	41040194	18088789	148	8362										
CYP2F1	1572	broad.mit.edu	37	chr19	41631523	41631523	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttcaagaagagtccagccttCatgcccttctcagctggtga	9	12	3	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:41631523C>T	uc002opu.1	+	9	1334	c.1278C>T	c.(1276-1278)TTC>TTT	p.F426F	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_3'UTR|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	426					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						GTCCAGCCTTCATGCCCTTCT	0.527													0	0	0	0.037714	0	10	95										T	41631523	C	T	41631523	2	4	31	1	0	0	0	0	0	0	0	1	4171	825	29	1		1	CYP2F1	19	41631523	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	591329	41631523	17497460	149	8363										
MBOAT7	79143	broad.mit.edu	37	chr19	54692145	54692145	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aaagtgtgggggccacaggtGaacagggtgagccccaggcc	17	10	0	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:54692145G>A	uc002qdq.2	-	4	398	c.132C>T	c.(130-132)TTC>TTT	p.F44F	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Silent_p.F26F|MBOAT7_uc002qdr.2_Silent_p.F44F|MBOAT7_uc002qds.2_Missense_Mutation_p.H14Y|MBOAT7_uc010yen.1_Missense_Mutation_p.H14Y|MBOAT7_uc002qdt.3_Silent_p.F44F|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	44	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGCCACAGGTGAACAGGGTGA	0.627													0	0	0	0.020292	0	15	44										A	54692145	G	A	54692145	2	1	31	1	0	0	0	0	0	0	0	1	9358	1290	45	1		1	MBOAT7	19	54692145	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	13060622	54692145	4436838	150	8364										
NLRP8	126205	broad.mit.edu	37	chr19	56466904	56466904	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tccttggcatgagtattcttCggagaattgcaggtgaggaa	13	6	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:56466904C>T	uc002qmh.2	+	3	1551	c.1480C>T	c.(1480-1482)CGG>TGG	p.R494W	NLRP8_uc010etg.2_Missense_Mutation_p.R494W	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	494	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGTATTCTTCGGAGAATTGC	0.468													0	0	0	0.020292	0	14	159										T	56466904	C	T	56466904	3	4	31	1	0	0	0	0	1	0	0	0	10483	875	31	1	1490	1	NLRP8	19	56466904	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	1774759	56466904	2662079	151	8365										
SEL1L2	80343	broad.mit.edu	37	chr20	13847482	13847482	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcaagtttataatccttccAtattccagagccagctgaaa	7	10	0	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:13847482A>G	uc010gcf.2	-	15	1352	c.1270T>C	c.(1270-1272)TGG>CGG	p.W424R	SEL1L2_uc002woq.3_Missense_Mutation_p.W285R|SEL1L2_uc010zrl.1_Missense_Mutation_p.W424R|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	424	Extracellular (Potential).|Sel1-like 8.					integral to membrane	binding			ovary(2)	2						TAATCCTTCCATATTCCAGAG	0.363													0	0	0	0.021553	0	6	61										G	13847482	A	G	13847482	3	3	31	1	0	0	0	0	1	0	0	0	14011	217	8	5	820	5	SEL1L2	20	13847482	Missense_Mutation	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08		13847482	49178038	152	8366										
C20orf186	149954	broad.mit.edu	37	chr20	31671341	31671341	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tgagatccttgagtccgaggGaagcatcagggacctccgaa	13	10	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:31671341G>A	uc010zue.1	+	3	353	c.338G>A	c.(337-339)GGA>GAA	p.G113E		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	113						cytoplasm|extracellular region	lipid binding				0						GAGTCCGAGGGAAGCATCAGG	0.552													0	0	0	0.009096	0	4	73										A	31671341	G	A	31671341	3	1	31	1	0	0	0	0	1	0	0	0	2098	1174	41	1	348	1	C20orf186	20	31671341	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	17823859	31671341	31354179	153	8367										
FAM83C	128876	broad.mit.edu	37	chr20	33879831	33879831	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcctcctgcccctgagcctCgctgagctcagggcccccgc	12	20	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:33879831C>T	uc010zux.1	-	1	395	c.277G>A	c.(277-279)GAG>AAG	p.E93K	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	93										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCCTGAGCCTCGCTGAGCTCA	0.662													0	0	0	0.010729	0	11	41										T	33879831	C	T	33879831	3	4	31	1	0	0	0	0	1	0	0	0	5635	893	31	1	1982	1	FAM83C	20	33879831	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	2208490	33879831	29145689	154	8368										
C20orf132	140699	broad.mit.edu	37	chr20	35766314	35766314	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtatttatgatttgttggcgGactctaggctggctgattat	12	5	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:35766314G>A	uc010zvu.1	-	15	1669	c.1578C>T	c.(1576-1578)GTC>GTT	p.V526V	C20orf132_uc002xgk.2_Silent_p.V148V|C20orf132_uc002xgm.2_Silent_p.V526V|C20orf132_uc002xgn.2_Silent_p.V491V	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	401											0		Myeloproliferative disorder(115;0.00878)				TTTGTTGGCGGACTCTAGGCT	0.408													0	0	0	0.014758	0	5	16										A	35766314	G	A	35766314	2	1	31	1	0	0	0	0	0	0	0	1	2086	1161	41	1		1	C20orf132	20	35766314	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1886483	35766314	27259206	155	8369										
ZNF335	63925	broad.mit.edu	37	chr20	44578441	44578441	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cagtagctagtagctcacctGgttgtcggaggtcaccaggt	13	10	2	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:44578441G>A	uc002xqw.2	-	24	3790	c.3667C>T	c.(3667-3669)CAG>TAG	p.Q1223*	ZNF335_uc002xqv.2_Nonsense_Mutation_p.Q335*|ZNF335_uc010zxk.1_Nonsense_Mutation_p.Q1068*	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1223	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TAGCTCACCTGGTTGTCGGAG	0.562													0	0	0	0.00308	0	7	65										A	44578441	G	A	44578441	4	1	31	1	0	0	0	0	0	1	0	0	17849	1357	47	2	381	2	ZNF335	20	44578441	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	8812127	44578441	18447079	156	8370										
ZMYND8	23613	broad.mit.edu	37	chr20	45850114	45850114	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ctcagcatccgcttcctgctGaggagcagtagctggggaca	13	12	1	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:45850114G>A	uc002xta.1	-	20	3462	c.3208C>T	c.(3208-3210)CAG>TAG	p.Q1070*	ZMYND8_uc010ghq.1_Nonsense_Mutation_p.Q701*|ZMYND8_uc010ghr.1_Nonsense_Mutation_p.Q972*|ZMYND8_uc002xst.1_Nonsense_Mutation_p.Q952*|ZMYND8_uc002xsu.1_Nonsense_Mutation_p.Q943*|ZMYND8_uc002xsv.1_Nonsense_Mutation_p.Q998*|ZMYND8_uc002xsw.1_Nonsense_Mutation_p.Q776*|ZMYND8_uc002xsx.1_Nonsense_Mutation_p.Q776*|ZMYND8_uc002xsy.1_Nonsense_Mutation_p.Q999*|ZMYND8_uc002xsz.1_Nonsense_Mutation_p.Q961*|ZMYND8_uc010zxy.1_Nonsense_Mutation_p.Q1097*|ZMYND8_uc002xtb.1_Nonsense_Mutation_p.Q1044*|ZMYND8_uc002xss.2_Nonsense_Mutation_p.Q1070*|ZMYND8_uc010zxz.1_Nonsense_Mutation_p.Q938*|ZMYND8_uc002xtc.1_Nonsense_Mutation_p.Q1044*|ZMYND8_uc002xtd.1_Nonsense_Mutation_p.Q1019*|ZMYND8_uc002xte.1_Nonsense_Mutation_p.Q1024*|ZMYND8_uc010zya.1_Nonsense_Mutation_p.Q1070*|ZMYND8_uc002xtf.1_Nonsense_Mutation_p.Q1090*|ZMYND8_uc002xsr.1_Nonsense_Mutation_p.Q169*	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1070							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCTTCCTGCTGAGGAGCAGTA	0.547													0	0	0	0.02938	0	7	25										A	45850114	G	A	45850114	4	1	31	1	0	0	0	0	0	1	0	0	17708	1299	45	1	452	1	ZMYND8	20	45850114	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	1271673	45850114	17175406	157	8371										
CCT8	10694	broad.mit.edu	37	chr21	30435690	30435690	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tacctcactaacatgatattAtatttatttgcataatgaag	4	6	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:30435690A>G	uc002ynb.2	-	8	1023	c.924T>C	c.(922-924)TAT>TAC	p.Y308Y	CCT8_uc002ymz.2_5'Flank|CCT8_uc011acp.1_Silent_p.Y289Y|CCT8_uc002yna.2_Silent_p.Y257Y|CCT8_uc002ync.2_Silent_p.Y307Y|CCT8_uc010glm.2_Silent_p.Y249Y|CCT8_uc011acq.1_Silent_p.Y235Y	NM_006585	NP_006576	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	308					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding				0						ACATGATATTATATTTATTTG	0.343													0	0	0	0.027356	0	25	32										G	30435690	A	G	30435690	2	3	31	1	0	0	0	0	0	0	0	1	2960	456	16	5		5	CCT8	21	30435690	Silent	SNP	A	TCGA-CF-A3MG-01A-11D-A20D-08		30435690	17694205	158	8372										
TMPRSS2	7113	broad.mit.edu	37	chr21	42848536	42848536	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagaaaccactgcttttgaaGaacaggcatcactgcaaaaa	7	9	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:42848536G>T	uc002yzj.2	-	8	829	c.695C>A	c.(694-696)TCT>TAT	p.S232Y	TMPRSS2_uc010gor.2_Missense_Mutation_p.S269Y|TMPRSS2_uc010gos.1_Missense_Mutation_p.S232Y	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	232	Extracellular (Potential).|SRCR.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				TGCTTTTGAAGAACAGGCATC	0.428			T	ERG|ETV1|ETV4|ETV5	prostate 								1	0	3.07112e-06	0.010729	3.19335e-06	10	57										T	42848536	G	T	42848536	3	4	31	1	0	0	0	0	1	0	0	0	16244	942	33	3	811	3	TMPRSS2	21	42848536	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	12412846	42848536	5281359	159	8373										
PDXK	8566	broad.mit.edu	37	chr21	45170387	45170387	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	cgcctgtcttccaggttactGagtggccggaagatccacag	12	12	1	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:45170387G>A	uc002zdm.3	+	7	669	c.471G>A	c.(469-471)CTG>CTA	p.L157L	PDXK_uc010gpj.2_Silent_p.L157L|PDXK_uc002zdn.3_Silent_p.L129L|PDXK_uc002zdq.3_Silent_p.L84L	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	157					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCAGGTTACTGAGTGGCCGGA	0.652													0	0	0	0.021553	0	4	21										A	45170387	G	A	45170387	2	1	31	1	0	0	0	0	0	0	0	1	11697	1277	45	1		1	PDXK	21	45170387	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	2321851	45170387	2959508	160	8374										
PDXK	8566	broad.mit.edu	37	chr21	45170412	45170412	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gccggaagatccacagccagGaggaagccttgcgggtaagg	16	10	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:45170412G>T	uc002zdm.3	+	7	694	c.496G>T	c.(496-498)GAG>TAG	p.E166*	PDXK_uc010gpj.2_Nonsense_Mutation_p.E166*|PDXK_uc002zdn.3_Nonsense_Mutation_p.E138*|PDXK_uc002zdq.3_Nonsense_Mutation_p.E93*	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	166					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCACAGCCAGGAGGAAGCCTT	0.652													1	0	5.18039e-06	0.00308	5.35991e-06	6	27										T	45170412	G	T	45170412	4	4	31	1	0	0	0	0	0	1	0	0	11697	1175	41	3	522	3	PDXK	21	45170412	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	25	45170412	2959483	161	8375										
CCT8L2	150160	broad.mit.edu	37	chr22	17072820	17072820	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	tccagtgtccccccgggcagCgcgcacaccccaacacgctc	9	21	0	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:17072820C>T	uc002zlp.1	-	1	881	c.621G>A	c.(619-621)GCG>GCA	p.A207A		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	207					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.A207V(1)		ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCCCGGGCAGCGCGCACACCC	0.617													0	0	0	0.023175	0	37	63										T	17072820	C	T	17072820	2	4	31	1	0	0	0	0	0	0	0	1	2961	755	27	2		2	CCT8L2	22	17072820	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08		17072820	34231746	162	8376										
CECR2	27443	broad.mit.edu	37	chr22	17976471	17976471	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	agctacctagaggacatcatCaactaccgctgggagctcga	10	12	2	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:17976471C>T	uc010gqw.1	+	2	258	c.132C>T	c.(130-132)ATC>ATT	p.I44I	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	86					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		AGGACATCATCAACTACCGCT	0.522													0	0	0	0.009096	0	4	22										T	17976471	C	T	17976471	2	4	31	1	0	0	0	0	0	0	0	1	3206	816	29	1		1	CECR2	22	17976471	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	903651	17976471	33328095	163	8377										
PRODH	5625	broad.mit.edu	37	chr22	18918708	18918708	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	aagtttcctggaaacatacaGcagctgaaaggcaaagggaa	11	7	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:18918708G>A	uc010grl.2	-	2	291	c.277C>T	c.(277-279)CTG>TTG	p.L93L	PRODH_uc002zoj.3_Intron|PRODH_uc002zol.3_5'UTR|PRODH_uc002zok.3_Silent_p.L93L	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	93					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	GAAACATACAGCAGCTGAAAG	0.547													0	0	0	0.020292	0	13	33										A	18918708	G	A	18918708	2	1	31	1	0	0	0	0	0	0	0	1	12548	962	34	2		2	PRODH	22	18918708	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	942237	18918708	32385858	164	8378										
MTMR3	8897	broad.mit.edu	37	chr22	30403146	30403146	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ttgcccgctgtggacagccaGaggttagctggtggggctgg	18	9	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:30403146G>C	uc003agv.3	+	10	1043	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	MTMR3_uc003agu.3_Missense_Mutation_p.E239Q|MTMR3_uc003agw.3_Missense_Mutation_p.E239Q	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	239	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TGGACAGCCAGAGGTTAGCTG	0.537													0	0	0	0.0333	0	16	53										C	30403146	G	C	30403146	3	2	31	1	0	0	0	0	1	0	0	0	9945	943	33	1	745	1	MTMR3	22	30403146	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	11484438	30403146	20901420	165	8379										
HMGXB4	10042	broad.mit.edu	37	chr22	35660675	35660675	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gaatcgtcacagaagaaaaaGaaaaagtccagcccacagtc	8	10	1	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:35660675G>C	uc003anl.2	+	5	468	c.294G>C	c.(292-294)AAG>AAC	p.K98N	HMGXB4_uc011amh.1_5'UTR|HMGXB4_uc003ank.2_5'UTR	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	98					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						AGAAGAAAAAGAAAAAGTCCA	0.438													0	0	0	0.016522	0	24	53										C	35660675	G	C	35660675	3	2	31	1	0	0	0	0	1	0	0	0	7239	933	33	1	308	1	HMGXB4	22	35660675	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	5257529	35660675	15643891	166	8380										
PDGFB	5155	broad.mit.edu	37	chr22	39626222	39626222	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ggcttcttccgcacaatctcGatctttctcacctggaggac	8	14	4	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:39626222G>A	uc003axf.2	-	5	1457	c.468C>T	c.(466-468)ATC>ATT	p.I156I	PDGFB_uc003axe.2_Silent_p.I141I	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	156					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	GCACAATCTCGATCTTTCTCA	0.582			T	COL1A1	DFSP								0	0	0	0.006122	0	16	37										A	39626222	G	A	39626222	2	1	31	1	0	0	0	0	0	0	0	1	11658	1048	37	1		1	PDGFB	22	39626222	Silent	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	3965547	39626222	11678344	167	8381										
ACR	49	broad.mit.edu	37	chr22	51182532	51182532	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	atggaggcacgtgtggatctCatcgacctggacttgtgtaa	13	8	1	0			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:51182532C>T	uc003bnh.3	+	4	621	c.609C>T	c.(607-609)CTC>CTT	p.L203L		NM_001097	NP_001088	P10323	ACRO_HUMAN	acrosin precursor	203	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		GTGTGGATCTCATCGACCTGG	0.567													0	0	0	0.01441	0	43	108										T	51182532	C	T	51182532	2	4	31	1	0	0	0	0	0	0	0	1	169	813	29	1		1	ACR	22	51182532	Silent	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	11556310	51182532	122034	168	8382										
TBL1X	6907	broad.mit.edu	37	chrX	9659696	9659696	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	ccacagtccttcggggccatGagtctgaggtgttcatttgt	12	10	2	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:9659696G>T	uc010ndq.2	+	8	1062	c.694G>T	c.(694-696)GAG>TAG	p.E232*	TBL1X_uc004csq.3_Nonsense_Mutation_p.E181*|TBL1X_uc010ndr.2_Nonsense_Mutation_p.E181*|TBL1X_uc004csr.2_Nonsense_Mutation_p.E232*|TBL1X_uc004css.2_Nonsense_Mutation_p.E183*	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	232	WD 1.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				TCGGGGCCATGAGTCTGAGGT	0.527													1	0	1.13719e-10	0.037714	1.23147e-10	30	5										T	9659696	G	T	9659696	4	4	31	1	0	0	0	0	0	1	0	0	15636	1291	45	3	712	3	TBL1X	23	9659696	Nonsense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08		9659696	145610864	169	8383										
ATRX	546	broad.mit.edu	37	chrX	76939532	76939532	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gtcttcttccaatgcaagatGagccttcttaatatcagcca	6	11	4	2			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:76939532G>C	uc004ecp.3	-	9	1448	c.1216C>G	c.(1216-1218)CAT>GAT	p.H406D	ATRX_uc004ecq.3_Missense_Mutation_p.H368D|ATRX_uc004eco.3_Missense_Mutation_p.H191D|ATRX_uc004ecr.2_Missense_Mutation_p.H367D|ATRX_uc010nlx.1_Missense_Mutation_p.H406D|ATRX_uc010nly.1_Missense_Mutation_p.H351D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	406					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATGCAAGATGAGCCTTCTTA	0.358			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.01441	0	71	87										C	76939532	G	C	76939532	3	2	31	1	0	0	0	0	1	0	0	0	1208	1290	45	1	6370	1	ATRX	23	76939532	Missense_Mutation	SNP	G	TCGA-CF-A3MG-01A-11D-A20D-08	67279836	76939532	78331028	170	8384										
GPR119	139760	broad.mit.edu	37	chrX	129518617	129518617	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gttgagcagggagttgcccaCgccgagcagccacaggtacc	14	13	0	1			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:129518617C>T	uc011muv.1	-	1	805	c.805G>A	c.(805-807)GTG>ATG	p.V269M		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	269	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GAGTTGCCCACGCCGAGCAGC	0.577													0	0	0	0.01441	0	63	1										T	129518617	C	T	129518617	3	4	31	1	0	0	0	0	1	0	0	0	6634	536	19	2	206	2	GPR119	23	129518617	Missense_Mutation	SNP	C	TCGA-CF-A3MG-01A-11D-A20D-08	52579085	129518617	25751943	171	8385										
MAGEC1	9947	broad.mit.edu	37	chrX	140993970	140993970	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459302325581395	79	1.93128708149725e-28	3.82818389491719	5.76650485436893	2.77091791703442	0.538619659596792	0.703427880543598	58	gagagaactcagagtactttTgagggttttgcccagtcttc	11	8	2	3			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:140993970T>C	uc004fbt.2	+	4	1066	c.780T>C	c.(778-780)TTT>TTC	p.F260F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	260							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGTACTTTTGAGGGTTTTG	0.498										HNSCC(15;0.026)			0	0	0	0.021553	0	5	87										C	140993970	T	C	140993970	2	2	31	1	0	0	0	0	0	0	0	1	9180	1809	63	5		5	MAGEC1	23	140993970	Silent	SNP	T	TCGA-CF-A3MG-01A-11D-A20D-08	11475353	140993970	14276590	172	8386										
AADACL4	343066	broad.mit.edu	37	chr1	12726726	12726726	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	agattgtgaatgctgtagtcAgttatataaagggcatatga	11	3	1	3			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:12726726A>T	uc001auf.2	+	4	1204	c.1204A>T	c.(1204-1206)AGT>TGT	p.S402C		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	402	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TGCTGTAGTCAGTTATATAAA	0.438													0	0	0	0.021553	0	5	85										T	12726726	A	T	12726726	3	4	32	1	0	0	0	0	1	0	0	0	13	188	7	5	1218	5	AADACL4	1	12726726	Missense_Mutation	SNP	A	TCGA-CF-A3MH-01A-11D-A20D-08		12726726	236523895	1	8387										
EIF4G3	8672	broad.mit.edu	37	chr1	21143902	21143902	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tacctctacccagtcaaagaTctgttcatcattcgctttgt	5	12	5	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:21143902T>C	uc001bec.2	-	29	4586	c.4330A>G	c.(4330-4332)ATC>GTC	p.I1444V	EIF4G3_uc010odi.1_Missense_Mutation_p.I1048V|EIF4G3_uc010odj.1_Missense_Mutation_p.I1443V|EIF4G3_uc009vpz.2_Missense_Mutation_p.I1164V|EIF4G3_uc001bed.2_Missense_Mutation_p.I1444V|EIF4G3_uc001bef.2_Missense_Mutation_p.I1480V|EIF4G3_uc001bee.2_Missense_Mutation_p.I1450V	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1444	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CAGTCAAAGATCTGTTCATCA	0.428													0	0	0	0.139131	0	45	43										C	21143902	T	C	21143902	3	2	32	1	0	0	0	0	1	0	0	0	5038	1435	50	5	443	5	EIF4G3	1	21143902	Missense_Mutation	SNP	T	TCGA-CF-A3MH-01A-11D-A20D-08	8417176	21143902	228106719	2	8388										
ZNF643	65243	broad.mit.edu	37	chr1	40928396	40928396	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aggaccaataggtcttccaaGaaaaagagatcgtaaatatg	9	6	1	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:40928396G>C	uc001cfn.1	+	5	1037	c.740G>C	c.(739-741)AGA>ACA	p.R247T	ZNF643_uc001cfl.1_Missense_Mutation_p.R145T|ZNF643_uc001cfm.1_Missense_Mutation_p.R113T	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			GGTCTTCCAAGAAAAAGAGAT	0.348													0	0	0	0.139131	0	53	57										C	40928396	G	C	40928396	3	2	32	1	0	0	0	0	1	0	0	0	18056	942	33	1	758	1	ZNF643	1	40928396	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	19784494	40928396	208322225	3	8389										
SARS	6301	broad.mit.edu	37	chr1	109777922	109777922	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	agcagcccattgctgccctgCaccgggatgagtggctccgg	14	14	0	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:109777922C>T	uc001dwu.1	+	7	913	c.838C>T	c.(838-840)CAC>TAC	p.H280Y	SARS_uc001dwt.1_Missense_Mutation_p.H280Y|SARS_uc001dwv.1_Missense_Mutation_p.H280Y|SARS_uc001dww.1_Missense_Mutation_p.H213Y|SARS_uc001dwx.1_Missense_Mutation_p.H232Y|SARS_uc009wfa.1_Missense_Mutation_p.H280Y|SARS_uc001dwy.1_Missense_Mutation_p.H105Y|SARS_uc001dwz.1_Missense_Mutation_p.H105Y	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	280					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TGCTGCCCTGCACCGGGATGA	0.587													0	0	0	0.139131	0	51	79										T	109777922	C	T	109777922	3	4	32	1	0	0	0	0	1	0	0	0	13844	710	25	2	864	2	SARS	1	109777922	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	68849526	109777922	139472699	4	8390										
LCE3D	84648	broad.mit.edu	37	chr1	152552263	152552263	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tggtggttcaggaagcagccGccctcggagctagggccaca	15	12	1	0	rs139649941		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:152552263G>A	uc001fab.2	-	2	207	c.150C>T	c.(148-150)GGC>GGT	p.G50G		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	50					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGAAGCAGCCGCCCTCGGAGC	0.672													0	0	0	0.047766	0	9	67										A	152552263	G	A	152552263	2	1	32	1	0	0	0	0	0	0	0	1	8672	1074	38	2		2	LCE3D	1	152552263	Silent	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	42774341	152552263	96698358	5	8391										
TMCC2	9911	broad.mit.edu	37	chr1	205210891	205210891	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	accgcgtgctgcagcagatcCgctcccggccctccatcaag	10	18	1	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:205210891C>T	uc001hbz.1	+	3	910	c.466C>T	c.(466-468)CGC>TGC	p.R156C	TMCC2_uc010prf.1_Missense_Mutation_p.R78C	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	156						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCAGCAGATCCGCTCCCGGCC	0.507													0	0	0	0.058154	0	7	18										T	205210891	C	T	205210891	3	4	32	1	0	0	0	0	1	0	0	0	15990	652	23	2	472	2	TMCC2	1	205210891	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	52658628	205210891	44039730	6	8392										
NLRP3	114548	broad.mit.edu	37	chr1	247607294	247607294	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gttggtgaattctggccttaCgtcagtctgttgttcagctt	11	8	4	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:247607294C>T	uc001icr.2	+	9	2828	c.2690C>T	c.(2689-2691)ACG>ATG	p.T897M	NLRP3_uc001ics.2_Missense_Mutation_p.T840M|NLRP3_uc001icu.2_Missense_Mutation_p.T897M|NLRP3_uc001icw.2_Missense_Mutation_p.T840M|NLRP3_uc001icv.2_Missense_Mutation_p.T783M|NLRP3_uc010pyw.1_Missense_Mutation_p.T875M	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	897	LRR 6.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCTGGCCTTACGTCAGTCTGT	0.512													0	0	0	0.043863	0	19	30										T	247607294	C	T	247607294	3	4	32	1	0	0	0	0	1	0	0	0	10478	536	19	2	2716	2	NLRP3	1	247607294	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	42396403	247607294	1643327	7	8393										
TTN	7273	broad.mit.edu	37	chr2	179394807	179394807	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	taagaagaaccctcccttgtCttcagagagtttatatttac	6	9	2	3			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:179394807C>G	uc010zfg.1	-	308	98931	c.98707G>C	c.(98707-98709)GAC>CAC	p.D32903H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D26598H|TTN_uc010zfi.1_Missense_Mutation_p.D26531H|TTN_uc010zfj.1_Missense_Mutation_p.D26406H|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33830							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCCTTGTCTTCAGAGAGT	0.348													0	0	0	0.146539	0	13	26										G	179394807	C	G	179394807	3	3	32	1	0	0	0	0	1	0	0	0	16732	913	32	1	1584	1	TTN	2	179394807	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08		179394807	63804566	8	8394										
TTN	7273	broad.mit.edu	37	chr2	179428319	179428319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gttgcacttggtccatctaaCgccttccttatctcgttttt	6	12	2	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:179428319C>T	uc010zfg.1	-	275	75060	c.74836G>A	c.(74836-74838)GTT>ATT	p.V24946I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V18641I|TTN_uc010zfi.1_Missense_Mutation_p.V18574I|TTN_uc010zfj.1_Missense_Mutation_p.V18449I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25873							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCATCTAACGCCTTCCTTA	0.463													0	0	0	0.139131	0	59	65										T	179428319	C	T	179428319	3	4	32	1	0	0	0	0	1	0	0	0	16732	536	19	2	25587	2	TTN	2	179428319	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	33512	179428319	63771054	9	8395										
C2orf66	401027	broad.mit.edu	37	chr2	197672317	197672317	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ccaagatcaagacctctgccCttaaaatatgcctgaagcct	6	13	2	3			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:197672317C>T	uc002utv.2	-	2	1093	c.204G>A	c.(202-204)AAG>AAA	p.K68K		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	68						extracellular region					0						GACCTCTGCCCTTAAAATATG	0.388													0	0	0	0.139131	0	41	74										T	197672317	C	T	197672317	2	4	32	1	0	0	0	0	0	0	0	1	2185	680	24	2		2	C2orf66	2	197672317	Silent	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	18243998	197672317	45527056	10	8396										
ANKRD44	91526	broad.mit.edu	37	chr2	197975551	197975551	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	acagctgtcatgtgcagtggActtttgccatctttactcta	8	10	3	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:197975551A>T	uc002uuc.2	-	9	1091	c.924T>A	c.(922-924)AGT>AGA	p.S308R	ANKRD44_uc002utz.3_5'UTR|ANKRD44_uc002uua.1_Missense_Mutation_p.S283R|ANKRD44_uc002uub.2_Missense_Mutation_p.S308R|ANKRD44_uc010zgw.1_Missense_Mutation_p.S236R	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	308	ANK 10.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTGCAGTGGACTTTTGCCAT	0.448													0	0	0	0.047766	0	8	166										T	197975551	A	T	197975551	3	4	32	1	0	0	0	0	1	0	0	0	672	272	10	5	1982	5	ANKRD44	2	197975551	Missense_Mutation	SNP	A	TCGA-CF-A3MH-01A-11D-A20D-08	303234	197975551	45223822	11	8397										
ATG16L1	55054	broad.mit.edu	37	chr2	234183394	234183394	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cctggttctggtaaagaagtGagggtaccagctactgcctt	12	9	1	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:234183394G>T	uc002vty.2	+	9	1181	c.924G>T	c.(922-924)GTG>GTT	p.V308V	ATG16L1_uc002vtx.1_Silent_p.V145V|ATG16L1_uc002vua.2_Silent_p.V289V|ATG16L1_uc002vub.2_Silent_p.V166V|ATG16L1_uc002vtz.2_Silent_p.V164V|ATG16L1_uc002vud.3_Silent_p.V224V|SCARNA5_uc002vue.1_5'Flank	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	308					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GTAAAGAAGTGAGGGTACCAG	0.473													1	0	2.35958e-20	0.11126	2.66405e-20	34	34										T	234183394	G	T	234183394	2	4	32	1	0	0	0	0	0	0	0	1	1091	1277	45	3		3	ATG16L1	2	234183394	Silent	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	36207843	234183394	9015979	12	8398										
MASP1	5648	broad.mit.edu	37	chr3	186968087	186968087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cgtcccatccttcagacactCaatctggaatgtgtccatct	6	14	4	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr3:186968087C>G	uc003frh.1	-	8	1374	c.1042G>C	c.(1042-1044)GAG>CAG	p.E348Q	MASP1_uc003fri.2_Missense_Mutation_p.E348Q|MASP1_uc003frj.2_Missense_Mutation_p.E317Q|MASP1_uc003frk.1_Missense_Mutation_p.E348Q|MASP1_uc011bse.1_Missense_Mutation_p.E322Q	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	348	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTCAGACACTCAATCTGGAAT	0.393													0	0	0	0.139131	0	79	136										G	186968087	C	G	186968087	3	3	32	1	0	0	0	0	1	0	0	0	9322	835	29	1	2038	1	MASP1	3	186968087	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08		186968087	11054343	13	8399										
WHSC2	7469	broad.mit.edu	37	chr4	1985711	1985711	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tcagaggcgaggtgggcgccGcaggcgtgggtgtggcaggg	23	8	1	1	rs149343602		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:1985711G>A	uc003gem.2	-	9	1439	c.1199C>T	c.(1198-1200)GCG>GTG	p.A400V	WHSC2_uc003gek.2_Missense_Mutation_p.A126V|WHSC2_uc003gel.2_Missense_Mutation_p.A314V|WHSC2_uc003gen.2_Missense_Mutation_p.A254V	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	389					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GGTGGGCGCCGCAGGCGTGGG	0.716													0	0	0	0.014758	0	3	34										A	1985711	G	A	1985711	3	1	32	1	0	0	0	0	1	0	0	0	17361	1087	38	2	432	2	WHSC2	4	1985711	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08		1985711	189168565	14	8400										
SH3BP2	6452	broad.mit.edu	37	chr4	2831730	2831731	+	Frame_Shift_Ins	INS	-	-	C													0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ctgaagatagctgaagaggaINSccccccaagggaggcagcca							TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:2831730_2831731insC	uc003gfi.3	+	8	1217_1218	c.1097_1098insC	c.(1096-1098)GACfs	p.D366fs	SH3BP2_uc011bvp.1_Frame_Shift_Ins_p.D394fs|SH3BP2_uc003gfj.3_Frame_Shift_Ins_p.D423fs|SH3BP2_uc003gfk.3_Frame_Shift_Ins_p.D366fs|SH3BP2_uc003gfl.3_Frame_Shift_Ins_p.D299fs|SH3BP2_uc003gfm.3_Frame_Shift_Ins_p.D341fs	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	366					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GCTGAAGAGGACCCCCCAAGGG	0.658									Cherubism									115	33	---	---								C	2831731	-	C	2831730	7	5	32	1	0	1	1	0	0	0	0	0	14245	275	10	0	1382	0	SH3BP2	4	2831730	Frame_Shift_Ins	INS	-	TCGA-CF-A3MH-01A-11D-A20D-08	846019	2831730	188322546	15	8401										
ADH6	130	broad.mit.edu	37	chr4	100137347	100137347	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aacttcctttgcctttggtgGggccacttctacctcttcaa	7	13	3	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:100137347G>T	uc003hup.3	-	2	185	c.91C>A	c.(91-93)CCA>ACA	p.P31T	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.P31T|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Missense_Mutation_p.P31T	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	31					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GCCTTTGGTGGGGCCACTTCT	0.403													1	0	6.45866e-13	0.104719	7.06416e-13	32	45										T	100137347	G	T	100137347	3	4	32	1	0	0	0	0	1	0	0	0	312	1232	43	4	1072	4	ADH6	4	100137347	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	97305617	100137347	91016929	16	8402										
HMGB2	3148	broad.mit.edu	37	chr4	174253235	174253240	+	In_Frame_Del	DEL	TCTTCA	TCTTCA	-													0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	attaaaggatagccatttatTcttcatcttcatcctcttcc							TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:174253235_174253240delTCTTCA	uc011ckc.1	-	4	741_746	c.621_626delTGAAGA	c.(619-627)GATGAAGAA>GAA	p.DE207del	HMGB2_uc003ita.3_In_Frame_Del_p.DE207del|HMGB2_uc003itb.2_In_Frame_Del_p.DE207del|HMGB2_uc003itc.2_3'UTR	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	207_208	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AGCCATTTAttcttcatcttcatcct	0.262																		59	112	---	---								-	174253240	TCTTCA	-	174253235	7	5	32	1	0	1	0	1	0	0	0	0	7226	1783	62	0	7	0	HMGB2	4	174253235	In_Frame_Del	DEL	TCTTCA	TCGA-CF-A3MH-01A-11D-A20D-08	74115888	174253235	16901041	17	8403										
F11	2160	broad.mit.edu	37	chr4	187209661	187209661	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	atgaggtctggcatctggtaGgcatcacgagctggggcgaa	16	8	3	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:187209661G>A	uc003iza.1	+	15	2104	c.1771G>A	c.(1771-1773)GGC>AGC	p.G591S	uc003izb.1_RNA	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	591	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GCATCTGGTAGGCATCACGAG	0.552													0	0	0	0.139131	0	53	82										A	187209661	G	A	187209661	3	1	32	1	0	0	0	0	1	0	0	0	5337	1000	35	2	1825	2	F11	4	187209661	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	12956426	187209661	3944615	18	8404										
PSMB9	5698	broad.mit.edu	37	chr6	32825140	32825140	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ctgatgcccaagccgtggccGacatggccgcctaccagctg	12	16	0	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:32825140G>A	uc003sga.2	+	4	268	c.193G>A	c.(193-195)GAC>AAC	p.D65N	PSMB9_uc011dqj.1_Intron	NM_148954	NP_683756	P28065	PSB9_HUMAN	proteasome beta 9 subunit isoform 2 proprotein	77					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0						AGCCGTGGCCGACATGGCCGC	0.602													0	0	0	0.014758	0	4	44										A	32825140	G	A	32825140	3	1	32	1	0	0	0	0	1	0	0	0	12684	1058	37	1	239	1	PSMB9	6	32825140	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08		32825140	138289927	19	8405										
THEMIS	387357	broad.mit.edu	37	chr6	128040858	128040858	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	attgctgtggccccacggttGctcctttctttctcttcatc	7	14	3	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:128040858G>T	uc003qbi.2	-	6	2188	c.1869C>A	c.(1867-1869)AGC>AGA	p.S623R	THEMIS_uc010kfa.2_Missense_Mutation_p.S526R|THEMIS_uc011ebt.1_Missense_Mutation_p.S662R|THEMIS_uc010kfb.2_Missense_Mutation_p.S588R	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	623					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CCCCACGGTTGCTCCTTTCTT	0.438													1	0	2.52991e-16	0.139131	2.81101e-16	40	47										T	128040858	G	T	128040858	3	4	32	1	0	0	0	0	1	0	0	0	15857	1310	46	4	64	4	THEMIS	6	128040858	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	95215718	128040858	43074209	20	8406										
C6orf192	116843	broad.mit.edu	37	chr6	133111328	133111328	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	atacttacatagtttccaaaTaccaaggatgccagcaactc	5	11	0	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:133111328T>C	uc003qdw.1	-	3	419	c.267A>G	c.(265-267)GTA>GTG	p.V89V	C6orf192_uc011eco.1_Missense_Mutation_p.I13V	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	hypothetical protein LOC116843	89	Helical; (Potential).				transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)		AGTTTCCAAATACCAAGGATG	0.313													0	0	0	0.014758	0	5	6										C	133111328	T	C	133111328	2	2	32	1	0	0	0	0	0	0	0	1	2349	1393	49	5		5	C6orf192	6	133111328	Silent	SNP	T	TCGA-CF-A3MH-01A-11D-A20D-08	5070470	133111328	38003739	21	8407										
PCLO	27445	broad.mit.edu	37	chr7	82451883	82451883	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ccctgcatcttccaggtgggTctgagtgacgctggttttgc	13	11	2	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr7:82451883T>C	uc003uhx.2	-	20	15008	c.14719A>G	c.(14719-14721)ACC>GCC	p.T4907A	PCLO_uc003uhv.2_Missense_Mutation_p.T4907A|PCLO_uc003uht.1_Missense_Mutation_p.T349A|PCLO_uc003uhu.1_Missense_Mutation_p.T328A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4769					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCAGGTGGGTCTGAGTGACG	0.502													0	0	0	0.139131	0	77	165										C	82451883	T	C	82451883	3	2	32	1	0	0	0	0	1	0	0	0	11583	1667	58	5	750	5	PCLO	7	82451883	Missense_Mutation	SNP	T	TCGA-CF-A3MH-01A-11D-A20D-08		82451883	76686780	22	8408										
TNFRSF10A	8797	broad.mit.edu	37	chr8	23056899	23056899	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gagtctgcgttgctcagaatCtcgttgtgagcattgtcctc	11	10	3	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:23056899C>G	uc003xda.2	-	8	959	c.894G>C	c.(892-894)GAG>GAC	p.E298D		NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	298	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TGCTCAGAATCTCGTTGTGAG	0.562													0	0	0	0.139131	0	67	11										G	23056899	C	G	23056899	3	3	32	1	0	0	0	0	1	0	0	0	16277	912	32	1	524	1	TNFRSF10A	8	23056899	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08		23056899	123307123	23	8409										
FAM110B	90362	broad.mit.edu	37	chr8	59059268	59059268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cctgcaccgtcactccttcgCggagtccctgaaggtctacc	9	17	2	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:59059268C>T	uc003xtj.1	+	5	1359	c.479C>T	c.(478-480)GCG>GTG	p.A160V		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	160						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CACTCCTTCGCGGAGTCCCTG	0.697													0	0	0	0.014758	0	5	18										T	59059268	C	T	59059268	3	4	32	1	0	0	0	0	1	0	0	0	5397	768	27	2	481	2	FAM110B	8	59059268	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	36002369	59059268	87304754	24	8410										
PREX2	80243	broad.mit.edu	37	chr8	68950493	68950493	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aacgggtgttttttcttttcGataatcttttggtgtactgc	9	6	2	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:68950493G>A	uc003xxv.1	+	7	832	c.805G>A	c.(805-807)GAT>AAT	p.D269N	PREX2_uc003xxu.1_Missense_Mutation_p.D269N|PREX2_uc011lez.1_Missense_Mutation_p.D204N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	269	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTTTCTTTTCGATAATCTTTT	0.398													0	0	0	0.083992	0	21	57										A	68950493	G	A	68950493	3	1	32	1	0	0	0	0	1	0	0	0	12477	1058	37	1	831	1	PREX2	8	68950493	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	9891225	68950493	77413529	25	8411										
TMEM55A	55529	broad.mit.edu	37	chr8	92008912	92008912	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	actccaatgaaaatacatatCattccaatggtaatatatgc	4	8	1	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:92008912C>T	uc003yes.2	-	6	826	c.600G>A	c.(598-600)ATG>ATA	p.M200I		NM_018710	NP_061180	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	200	Helical; (Potential).					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(11;0.033)			AAATACATATCATTCCAATGG	0.393													0	0	0	0.043863	0	14	36										T	92008912	C	T	92008912	3	4	32	1	0	0	0	0	1	0	0	0	16178	826	29	1	181	1	TMEM55A	8	92008912	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	23058419	92008912	54355110	26	8412										
PDP1	54704	broad.mit.edu	37	chr8	94934837	94934837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aaaatgcagtggagagcggcCgggcactgctacccattctc	12	12	1	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:94934837C>T	uc003yge.2	+	2	819	c.550C>T	c.(550-552)CGG>TGG	p.R184W	PDP1_uc003ygf.2_Missense_Mutation_p.R209W|PDP1_uc010max.2_Missense_Mutation_p.R209W|PDP1_uc011lgm.1_Missense_Mutation_p.R184W|PDP1_uc011lgn.1_Missense_Mutation_p.R243W	NM_018444	NP_060914	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic	184					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						GGAGAGCGGCCGGGCACTGCT	0.453													0	0	0	0.144211	0	29	49										T	94934837	C	T	94934837	3	4	32	1	0	0	0	0	1	0	0	0	11685	643	23	2	733	2	PDP1	8	94934837	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	2925925	94934837	51429185	27	8413										
PKHD1L1	93035	broad.mit.edu	37	chr8	110448690	110448690	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aacctgcaggacaccaaaagTaaggcctctgatttcagtca	8	11	3	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:110448690T>C	uc003yne.2	+	30	3731	c.3627_splice	c.e30+2	p.K1209_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACCAAAAGTAAGGCCTCTG	0.393										HNSCC(38;0.096)			0	0	0	0.134883	0	26	14										C	110448690	T	C	110448690	5	2	32	1	0	0	0	0	0	0	1	0	11972	1652	57	5	3747	5	PKHD1L1	8	110448690	Splice_Site	SNP	T	TCGA-CF-A3MH-01A-11D-A20D-08	15513853	110448690	35915332	28	8414										
ANUBL1	93550	broad.mit.edu	37	chr10	46121709	46121709	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cttgaaagcaagtagtcctaGagaaagaagaatcagttatg	10	5	1	4			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr10:46121709G>A	uc001jcp.3	-	7	1804	c.1562C>T	c.(1561-1563)TCT>TTT	p.S521F	ANUBL1_uc001jcl.3_Missense_Mutation_p.S41F|ANUBL1_uc001jcm.3_Missense_Mutation_p.S521F|ANUBL1_uc009xmu.2_Missense_Mutation_p.S447F|ANUBL1_uc001jcn.3_Missense_Mutation_p.S447F|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	521							zinc ion binding				0						AGTAGTCCTAGAGAAAGAAGA	0.393													0	0	0	0.021553	0	5	69										A	46121709	G	A	46121709	3	1	32	1	0	0	0	0	1	0	0	0	713	942	33	1	637	1	ANUBL1	10	46121709	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08		46121709	89413038	29	8415										
OR6Q1	219952	broad.mit.edu	37	chr11	57798438	57798438	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gccacatatgcaaccatataCcaaaaactggacccaggtaa	6	12	0	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr11:57798438C>T	uc010rjz.1	+	1	14	c.14C>T	c.(13-15)ACC>ATC	p.T5I	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CAACCATATACCAAAAACTGG	0.458													0	0	0	0.047766	0	8	205										T	57798438	C	T	57798438	3	4	32	1	0	0	0	0	1	0	0	0	11208	507	18	2	16	2	OR6Q1	11	57798438	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08		57798438	77208078	30	8416										
WNK1	65125	broad.mit.edu	37	chr12	1017767	1017767	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	taggtcacttcaccaagtctAtgtgccccccacagcagtat	7	14	3	0	rs144574284	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:1017767A>G	uc001qio.3	+	28	7465	c.6958A>G	c.(6958-6960)ATG>GTG	p.M2320V	WNK1_uc001qip.3_Missense_Mutation_p.M2072V|WNK1_uc001qir.3_Missense_Mutation_p.M1493V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2320					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CACCAAGTCTATGTGCCCCCC	0.592													0	0	0	0.139131	0	64	40										G	1017767	A	G	1017767	3	3	32	1	0	0	0	0	1	0	0	0	17374	449	16	5	8570	5	WNK1	12	1017767	Missense_Mutation	SNP	A	TCGA-CF-A3MH-01A-11D-A20D-08		1017767	132834128	31	8417										
GALNT8	26290	broad.mit.edu	37	chr12	4835915	4835915	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cagaaggcggcccaggacctCttccggaagtttggttacaa	12	11	1	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:4835915C>G	uc001qne.1	+	2	521	c.429C>G	c.(427-429)CTC>CTG	p.L143L		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	143	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CCCAGGACCTCTTCCGGAAGT	0.557													0	0	0	0.139131	0	85	44										G	4835915	C	G	4835915	2	3	32	1	0	0	0	0	0	0	0	1	6219	900	32	1		1	GALNT8	12	4835915	Silent	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	3818148	4835915	129015980	32	8418										
SLC2A13	114134	broad.mit.edu	37	chr12	40499377	40499377	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gccaccacgtacacgaaggcGggggtctcgtcctgctggaa	14	13	1	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:40499377G>A	uc010skm.1	-	1	285	c.234C>T	c.(232-234)CCC>CCT	p.P78P	SLC2A13_uc001rmf.2_Silent_p.P78P	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	78	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				ACACGAAGGCGGGGGTCTCGT	0.478										HNSCC(50;0.14)			0	0	0	0.058154	0	6	7										A	40499377	G	A	40499377	2	1	32	1	0	0	0	0	0	0	0	1	14542	1103	39	2		2	SLC2A13	12	40499377	Silent	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	35663462	40499377	93352518	33	8419										
GIT2	9815	broad.mit.edu	37	chr12	110391020	110391020	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tgctggttattgatggttttCagtatgagctccacattgtc	10	7	1	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:110391020C>T	uc001tps.2	-	13	1284	c.1119G>A	c.(1117-1119)CTG>CTA	p.L373L	TCHP_uc001tpo.1_RNA|GIT2_uc001tpr.2_5'UTR|GIT2_uc001tpq.2_Silent_p.L373L|GIT2_uc001tpv.2_Silent_p.L375L|GIT2_uc001tpu.2_Silent_p.L373L|GIT2_uc001tpt.2_Silent_p.L373L|GIT2_uc010sxu.1_Silent_p.L311L|GIT2_uc001tpw.2_Silent_p.L373L|GIT2_uc010sxv.1_Silent_p.L373L	NM_057169	NP_476510	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting	373					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1						TGATGGTTTTCAGTATGAGCT	0.413													0	0	0	0.139131	0	48	134										T	110391020	C	T	110391020	2	4	32	1	0	0	0	0	0	0	0	1	6397	813	29	1		1	GIT2	12	110391020	Silent	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	69891643	110391020	23460875	34	8420										
ZFYVE19	84936	broad.mit.edu	37	chr15	41105570	41105570	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tatcgcctcccagacagtgaTgacgacgaggatgaggagac	13	10	0	5			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:41105570T>C	uc001zmt.1	+	8	1579	c.1065T>C	c.(1063-1065)GAT>GAC	p.D355D	ZFYVE19_uc001zmu.1_Silent_p.D287D|ZFYVE19_uc001zmv.1_Silent_p.D180D|ZFYVE19_uc001zmw.1_Silent_p.D180D|ZFYVE19_uc001zmx.1_Silent_p.D180D|ZFYVE19_uc010bcc.1_Silent_p.D180D	NM_001077268	NP_001070736	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	355	Potential.						zinc ion binding				0		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CAGACAGTGATGACGACGAGG	0.587													0	0	0	0.09319	0	9	23										C	41105570	T	C	41105570	2	2	32	1	0	0	0	0	0	0	0	1	17662	1461	51	5		5	ZFYVE19	15	41105570	Silent	SNP	T	TCGA-CF-A3MH-01A-11D-A20D-08		41105570	61425822	35	8421										
ANXA2	302	broad.mit.edu	37	chr15	60641322	60641322	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tactttctcttgaattcagaCctaattttcaacatgtccac	3	11	3	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:60641322C>A	uc002agn.2	-	13	1072	c.912G>T	c.(910-912)AGG>AGT	p.R304S	ANXA2_uc002agk.2_Missense_Mutation_p.R304S|ANXA2_uc002agl.2_Missense_Mutation_p.R304S|ANXA2_uc002agm.2_Missense_Mutation_p.R322S|ANXA2_uc010uhd.1_RNA	NM_001136015	NP_001129487	P07355	ANXA2_HUMAN	annexin A2 isoform 2	304	Annexin 4.				angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	TGAATTCAGACCTAATTTTCA	0.502													1	0	3.27435e-08	0.11911	3.4728e-08	14	57										A	60641322	C	A	60641322	3	1	32	1	0	0	0	0	1	0	0	0	718	506	18	4	115	4	ANXA2	15	60641322	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	19535752	60641322	41890070	36	8422										
C15orf39	56905	broad.mit.edu	37	chr15	75501097	75501097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gctgaagttactggcgctgcGccagctgccggacatttacc	12	13	0	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:75501097G>A	uc002azp.3	+	2	3028	c.2708G>A	c.(2707-2709)CGC>CAC	p.R903H	C15orf39_uc002azq.3_Missense_Mutation_p.R903H|C15orf39_uc002azr.3_Missense_Mutation_p.R301H	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	903											0						CTGGCGCTGCGCCAGCTGCCG	0.697													0	0	0	0.144211	0	22	19										A	75501097	G	A	75501097	3	1	32	1	0	0	0	0	1	0	0	0	1793	1087	38	2	2710	2	C15orf39	15	75501097	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	14859775	75501097	27030295	37	8423										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651669	84651669	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gcatggatacagcccagtttGatgagctgataagaaacatg	11	7	0	4			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:84651669G>C	uc002bjz.3	+	21	3513	c.3289G>C	c.(3289-3291)GAT>CAT	p.D1097H	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.D1097H|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.D1097H	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1097						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCCCAGTTTGATGAGCTGAT	0.473													0	0	0	0.183431	0	31	64										C	84651669	G	C	84651669	3	2	32	1	0	0	0	0	1	0	0	0	276	1290	45	1	3367	1	ADAMTSL3	15	84651669	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	9150572	84651669	17879723	38	8424										
ANKFY1	51479	broad.mit.edu	37	chr17	4086731	4086732	+	Frame_Shift_Ins	INS	-	-	GC													0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ggtgctccagcaggaagagtINSgcgctcttgctgtcctgccg							TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:4086731_4086732insGC	uc002fxq.1	-	14	1951_1952	c.1913_1914insGC	c.(1912-1914)GCAfs	p.A638fs	ANKFY1_uc002fxn.2_Frame_Shift_Ins_p.A680fs|ANKFY1_uc002fxo.2_Frame_Shift_Ins_p.A638fs|ANKFY1_uc002fxp.2_Frame_Shift_Ins_p.A637fs|ANKFY1_uc010ckp.2_Frame_Shift_Ins_p.A579fs	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	638	ANK 9.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						GCAGGAAGAGTGCGCTCTTGCT	0.55																		60	104	---	---								GC	4086732	-	GC	4086731	7	5	32	1	0	1	1	0	0	0	0	0	626	1683	59	0	1646	0	ANKFY1	17	4086731	Frame_Shift_Ins	INS	-	TCGA-CF-A3MH-01A-11D-A20D-08		4086731	77108479	39	8425										
PITPNC1	26207	broad.mit.edu	37	chr17	65671602	65671602	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ttttactttttaggtggtccGagacattctgctgattggac	10	7	1	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:65671602G>A	uc002jgc.2	+	8	973	c.626G>A	c.(625-627)CGA>CAA	p.R209Q	PITPNC1_uc002jgb.2_Missense_Mutation_p.R209Q	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	209					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			TAGGTGGTCCGAGACATTCTG	0.373													0	0	0	0.175082	0	15	96										A	65671602	G	A	65671602	3	1	32	1	0	0	0	0	1	0	0	0	11949	1058	37	1	656	1	PITPNC1	17	65671602	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	61584871	65671602	15523608	40	8426										
CABLES1	91768	broad.mit.edu	37	chr18	20716015	20716023	+	In_Frame_Del	DEL	GGCGCCGGC	GGCGCCGGC	-													0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	agggcggcgcggccaagccgGgcgccggcggcgcctgcggc							TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr18:20716015_20716023delGGCGCCGGC	uc002kuc.2	+	1	289_297	c.289_297delGGCGCCGGC	c.(289-297)GGCGCCGGCdel	p.GAG97del	CABLES1_uc002kub.2_Intron	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	97_99	Ala-rich.|Interacts with TDRD7 (By similarity).				blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ggccaagccgggcgccggcggcgcctgcg	0.593																		4	2	---	---								-	20716023	GGCGCCGGC	-	20716015	7	5	32	1	0	1	0	1	0	0	0	0	2529	1232	43	0	291	0	CABLES1	18	20716015	In_Frame_Del	DEL	GGCGCCGGC	TCGA-CF-A3MH-01A-11D-A20D-08		20716015	57361233	41	8427										
DOT1L	84444	broad.mit.edu	37	chr19	2220125	2220125	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	agaggagcacccccagtcccGtgctgcagccccgtgacccc	11	19	0	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:2220125G>A	uc002lvb.3	+	23	2746	c.2710G>A	c.(2710-2712)GTG>ATG	p.V904M	DOT1L_uc002lvc.1_Missense_Mutation_p.V198M|DOT1L_uc002lve.1_Missense_Mutation_p.V198M	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	904						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCAGTCCCGTGCTGCAGCC	0.617													0	0	0	0.02938	0	5	75										A	2220125	G	A	2220125	3	1	32	1	0	0	0	0	1	0	0	0	4709	1145	40	2	2800	2	DOT1L	19	2220125	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08		2220125	56908858	42	8428										
MUC16	94025	broad.mit.edu	37	chr19	9090831	9090831	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ttgcttagtgtcatggaaaaAgggatagctgagttgggcat	14	4	1	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:9090831A>G	uc002mkp.2	-	1	1188	c.984T>C	c.(982-984)CCT>CCC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGAAAAAGGGATAGCTG	0.522													0	0	0	0.115264	0	3	86										G	9090831	A	G	9090831	2	3	32	1	0	0	0	0	0	0	0	1	9973	59	3	5		5	MUC16	19	9090831	Silent	SNP	A	TCGA-CF-A3MH-01A-11D-A20D-08	6870706	9090831	50038152	43	8429										
CILP2	148113	broad.mit.edu	37	chr19	19655933	19655933	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cttcaagcgtaacggcttccGcatcaacctcgccaagccca	7	17	2	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:19655933G>A	uc002nmv.3	+	8	2664	c.2579G>A	c.(2578-2580)CGC>CAC	p.R860H	CILP2_uc002nmw.3_Missense_Mutation_p.R866H	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	860						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						AACGGCTTCCGCATCAACCTC	0.701													0	0	0	0.150653	0	4	76										A	19655933	G	A	19655933	3	1	32	1	0	0	0	0	1	0	0	0	3430	1087	38	2	2609	2	CILP2	19	19655933	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	10565102	19655933	39473050	44	8430										
ZNF737	100129842	broad.mit.edu	37	chr19	20728097	20728097	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	ttctctccgctatgaattatCttatgcgcagtaaggataga	8	8	2	2			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:20728097C>T	uc002npa.2	-	4	1092	c.912G>A	c.(910-912)AAG>AAA	p.K304K		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	304					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TATGAATTATCTTATGCGCAG	0.408													0	0	0	0.153744	0	30	44										T	20728097	C	T	20728097	2	4	32	1	0	0	0	0	0	0	0	1	18123	912	32	1		1	ZNF737	19	20728097	Silent	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	1072164	20728097	38400886	45	8431										
ZNF681	148213	broad.mit.edu	37	chr19	23927314	23927314	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aggtgtgaggactggttaaaGgctttgccacattcttcaca	11	8	2	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:23927314G>A	uc002nrk.3	-	4	1180	c.1038C>T	c.(1036-1038)GCC>GCT	p.A346A	ZNF681_uc002nrl.3_Silent_p.A277A|ZNF681_uc002nrj.3_Silent_p.A277A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	346	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACTGGTTAAAGGCTTTGCCAC	0.433													0	0	0	0.047766	0	5	158										A	23927314	G	A	23927314	2	1	32	1	0	0	0	0	0	0	0	1	18085	987	35	2		2	ZNF681	19	23927314	Silent	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	3199217	23927314	35201669	46	8432										
ATP4A	495	broad.mit.edu	37	chr19	36050775	36050775	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	catgaagaagaccatggcccGcaggaaggtgtagccaatgc	13	10	0	3			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:36050775G>A	uc002oal.1	-	7	1017	c.988C>T	c.(988-990)CGG>TGG	p.R330W	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	330	Lumenal (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ACCATGGCCCGCAGGAAGGTG	0.577													0	0	0	0.099896	0	27	27										A	36050775	G	A	36050775	3	1	32	1	0	0	0	0	1	0	0	0	1145	1086	38	2	2183	2	ATP4A	19	36050775	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	12123461	36050775	23078208	47	8433										
CATSPERG	57828	broad.mit.edu	37	chr19	38847487	38847487	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	aagtaaacgtttccaggtggTcagctacaacacaggtaatg	10	8	1	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:38847487T>C	uc002oih.3	+	11	1388	c.1301T>C	c.(1300-1302)GTC>GCC	p.V434A	CATSPERG_uc002oig.3_Intron|CATSPERG_uc002oif.3_Missense_Mutation_p.V74A|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	434	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TTCCAGGTGGTCAGCTACAAC	0.527													0	0	0	0.139131	0	74	99										C	38847487	T	C	38847487	3	2	32	1	0	0	0	0	1	0	0	0	2692	1667	58	5	1339	5	CATSPERG	19	38847487	Missense_Mutation	SNP	T	TCGA-CF-A3MH-01A-11D-A20D-08	2796712	38847487	20281496	48	8434										
CYP2B6	1555	broad.mit.edu	37	chr19	41518645	41518645	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	actactttgaaaaaccagacGccttcaatcctgaccacttt	4	13	1	3			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:41518645G>T	uc002opr.1	+	8	1226	c.1219G>T	c.(1219-1221)GCC>TCC	p.A407S	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.A207S	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	407					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AAAACCAGACGCCTTCAATCC	0.458													1	0	1.16149e-67	0.139131	1.33286e-67	109	101										T	41518645	G	T	41518645	3	4	32	1	0	0	0	0	1	0	0	0	4164	1087	38	4	1249	4	CYP2B6	19	41518645	Missense_Mutation	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08	2671158	41518645	17610338	49	8435										
KLK15	55554	broad.mit.edu	37	chr19	51330226	51330226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	cctcccccgggtgggggcaaCgcgtgggtagcaccgcgggg	19	14	0	0			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:51330226C>T	uc002ptl.2	-	3	420	c.389G>A	c.(388-390)CGT>CAT	p.R130H	KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Missense_Mutation_p.R130H|KLK15_uc002pto.2_Missense_Mutation_p.R129H|KLK15_uc010ych.1_Intron|KLK15_uc010yci.1_Missense_Mutation_p.R129H|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	130	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GTGGGGGCAACGCGTGGGTAG	0.706													0	0	0	0.173368	0	29	34										T	51330226	C	T	51330226	3	4	32	1	0	0	0	0	1	0	0	0	8403	536	19	2	393	2	KLK15	19	51330226	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	9811581	51330226	7798757	50	8436										
KRTAP27-1	643812	broad.mit.edu	37	chr21	31709534	31709534	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	gatgcacgttccagagtttcGaaatttttagacttagaagt	9	6	0	3			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:31709534G>A	uc002ynx.1	-	1	479	c.453C>T	c.(451-453)TTC>TTT	p.F151F		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	151						intermediate filament		p.F151S(1)		ovary(2)	2						CCAGAGTTTCGAAATTTTTAG	0.493													0	0	0	0.139131	0	81	100										A	31709534	G	A	31709534	2	1	32	1	0	0	0	0	0	0	0	1	8544	1049	37	1		1	KRTAP27-1	21	31709534	Silent	SNP	G	TCGA-CF-A3MH-01A-11D-A20D-08		31709534	16420361	51	8437										
UMODL1	89766	broad.mit.edu	37	chr21	43519101	43519101	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	acagttttcaagtatcctggCgtttaaattctacacagaac	6	9	2	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:43519101C>T	uc002zaf.1	+	7	997	c.997C>T	c.(997-999)CGT>TGT	p.R333C	UMODL1_uc002zad.1_Missense_Mutation_p.R261C|UMODL1_uc002zae.1_Missense_Mutation_p.R261C|UMODL1_uc002zag.1_Missense_Mutation_p.R333C|UMODL1_uc010gow.1_Missense_Mutation_p.R125C|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_5'UTR|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.R78C	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	333	Extracellular (Potential).|Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AGTATCCTGGCGTTTAAATTC	0.522													0	0	0	0.014758	0	5	119										T	43519101	C	T	43519101	3	4	32	1	0	0	0	0	1	0	0	0	16977	768	27	2	1023	2	UMODL1	21	43519101	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	11809567	43519101	4610794	52	8438										
TRPM2	7226	broad.mit.edu	37	chr21	45784025	45784025	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tgtgtcagtgtggctacacgCatgagcagcacttggaggag	15	8	1	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:45784025C>T	uc002zet.1	+	4	496	c.283C>T	c.(283-285)CAT>TAT	p.H95Y	TRPM2_uc002zeu.1_Missense_Mutation_p.H95Y|TRPM2_uc002zew.1_Missense_Mutation_p.H95Y|TRPM2_uc010gpt.1_Missense_Mutation_p.H95Y	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	95	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGGCTACACGCATGAGCAGCA	0.423													0	0	0	0.083992	0	23	23										T	45784025	C	T	45784025	3	4	32	1	0	0	0	0	1	0	0	0	16583	710	25	2	293	2	TRPM2	21	45784025	Missense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08	2264924	45784025	2345870	53	8439										
HPS4	89781	broad.mit.edu	37	chr22	26868322	26868322	+	Frame_Shift_Del	DEL	G	G	-													0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	atcttatgcagatcactggtGtttttcagaatttgctcgat							TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr22:26868322delG	uc003acl.2	-	6	1106	c.447delC	c.(445-447)AACfs	p.N149fs	HPS4_uc003aci.2_Frame_Shift_Del_p.N144fs|HPS4_uc003acj.2_5'UTR|HPS4_uc003ack.2_5'UTR|HPS4_uc003acn.2_5'UTR|HPS4_uc010gvd.1_Frame_Shift_Del_p.N149fs|HPS4_uc003ach.2_5'UTR	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	149					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GATCACTGGTGTTTTTCAGAA	0.393									Hermansky-Pudlak_syndrome									68	104	---	---								-	26868322	G	-	26868322	7	5	32	1	0	1	0	1	0	0	0	0	7341	1368	48	0	1715	0	HPS4	22	26868322	Frame_Shift_Del	DEL	G	TCGA-CF-A3MH-01A-11D-A20D-08		26868322	24436244	54	8440										
TLR7	51284	broad.mit.edu	37	chrX	12905875	12905875	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.181818181818182	10	0.0246824186958949	2.0256157635468	7.08965517241379	0.977883472057075	0.66992140985949	0.777587350729765	5	tacaagatgccttccagttgCgatatctggatctcagctca	8	11	3	1			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chrX:12905875C>T	uc004cvc.2	+	3	2387	c.2248C>T	c.(2248-2250)CGA>TGA	p.R750*		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	750	Extracellular (Potential).|LRR 26.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CTTCCAGTTGCGATATCTGGA	0.383													0	0	0	0.02938	0	7	53										T	12905875	C	T	12905875	4	4	32	1	0	0	0	0	0	1	0	0	15953	760	27	2	2254	2	TLR7	23	12905875	Nonsense_Mutation	SNP	C	TCGA-CF-A3MH-01A-11D-A20D-08		12905875	142364685	55	8441										
RAP1GAP	5909	broad.mit.edu	37	chr1	21934840	21934840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	caggagggcggcccgcgtccGctcctgtgggccaggcccgg	18	16	0	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:21934840G>A	uc001bex.2	-	17	1420	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W	RAP1GAP_uc001bev.2_Missense_Mutation_p.R388W|RAP1GAP_uc001bew.2_Missense_Mutation_p.R452W|RAP1GAP_uc001bey.2_Missense_Mutation_p.R388W	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	388	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GCCCGCGTCCGCTCCTGTGGG	0.647													0	0	0	0.004672	0	3	31										A	21934840	G	A	21934840	3	1	33	1	0	0	0	0	1	0	0	0	13037	1086	38	2	943	2	RAP1GAP	1	21934840	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		21934840	227315781	1	8442										
TCHHL1	126637	broad.mit.edu	37	chr1	152058669	152058669	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tgctaaatcttgtgttctttCtcttgcccccagtgtccttt	6	12	3	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:152058669C>G	uc001ezo.1	-	3	1554	c.1489G>C	c.(1489-1491)GAA>CAA	p.E497Q		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	497							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGTGTTCTTTCTCTTGCCCCC	0.478													0	0	0	0.017118	0	33	168										G	152058669	C	G	152058669	3	3	33	1	0	0	0	0	1	0	0	0	15698	922	32	1	1229	1	TCHHL1	1	152058669	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	130123829	152058669	97191952	2	8443										
FAM129A	116496	broad.mit.edu	37	chr1	184787960	184787960	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cgccggctgggccaccatcgCtgaggtaggaaatagccaaa	13	12	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:184787960C>T	uc001gra.2	-	9	1180	c.986_splice	c.e9-1	p.A329_splice	FAM129A_uc001grb.1_Splice_Site_p.A92_splice|FAM129A_uc009wyh.1_Splice_Site_p.A157_splice|FAM129A_uc009wyi.1_Splice_Site_p.A127_splice	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2						negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						GCCACCATCGCTGAGGTAGGA	0.562													0	0	0	0.019004	0	33	114										T	184787960	C	T	184787960	5	4	33	1	0	0	0	0	0	0	1	0	5436	811	28	2	1825	2	FAM129A	1	184787960	Splice_Site	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	32729291	184787960	64462661	3	8444										
OBSCN	84033	broad.mit.edu	37	chr1	228462331	228462331	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gtggtcgcagaggagggcggCgaggccaccttccagtgcgt	18	11	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr1:228462331C>T	uc009xez.1	+	20	5786	c.5742C>T	c.(5740-5742)GGC>GGT	p.G1914G	OBSCN_uc001hsn.2_Silent_p.G1914G	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1914	Ig-like 19.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGGAGGGCGGCGAGGCCACCT	0.627													0	0	0	0.004482	0	7	16										T	228462331	C	T	228462331	2	4	33	1	0	0	0	0	0	0	0	1	10812	755	27	2		2	OBSCN	1	228462331	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	43674371	228462331	20788290	4	8445										
SMEK2	57223	broad.mit.edu	37	chr2	55791550	55791550	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cttttccttcctcttcttcaTcttcattaaaccacatttct	0	14	6	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:55791550T>A	uc002rzc.2	-	15	2534	c.2159A>T	c.(2158-2160)GAT>GTT	p.D720V	SMEK2_uc002rzb.2_Missense_Mutation_p.D635V|SMEK2_uc002rzd.2_Missense_Mutation_p.D688V|SMEK2_uc002ryz.2_Missense_Mutation_p.D147V|SMEK2_uc002rza.2_Missense_Mutation_p.D504V	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	720	Poly-Glu.					microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTCTTCTTCATCTTCATTAAA	0.358													0	0	0	0.020292	0	13	27										A	55791550	T	A	55791550	3	1	33	1	0	0	0	0	1	0	0	0	14794	1435	50	5	402	5	SMEK2	2	55791550	Missense_Mutation	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08		55791550	187407823	5	8446										
FAM119A	151194	broad.mit.edu	37	chr2	208477805	208477805	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ctggtttctcttctgtgcttCgtaaatatgtacatcttttt	6	8	3	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr2:208477805C>T	uc002vcf.2	-	4	782	c.622G>A	c.(622-624)GAA>AAA	p.E208K	FAM119A_uc002vce.2_Intron|FAM119A_uc010fuk.1_Missense_Mutation_p.E208K|FAM119A_uc002vcg.3_Missense_Mutation_p.E208K	NM_145280	NP_660323	Q8WXB1	MT21A_HUMAN	hypothetical protein LOC151194	208						integral to membrane	methyltransferase activity				0				LUSC - Lung squamous cell carcinoma(261;0.0705)|Epithelial(149;0.131)|Lung(261;0.135)		TTCTGTGCTTCGTAAATATGT	0.368													0	0	0	0.010504	0	21	70										T	208477805	C	T	208477805	3	4	33	1	0	0	0	0	1	0	0	0	5413	893	31	1	38	1	FAM119A	2	208477805	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	152686255	208477805	34721568	6	8447										
COL7A1	1294	broad.mit.edu	37	chr3	48623808	48623808	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gggctgaatatgtcacctctCaagggttcatccactagcag	10	11	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:48623808C>G	uc003ctz.2	-	26	3508	c.3507G>C	c.(3505-3507)TTG>TTC	p.L1169F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1169	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTCACCTCTCAAGGGTTCAT	0.587													0	0	0	0.01441	0	68	200										G	48623808	C	G	48623808	3	3	33	1	0	0	0	0	1	0	0	0	3704	825	29	1	5699	1	COL7A1	3	48623808	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		48623808	149398622	7	8448										
MON1A	84315	broad.mit.edu	37	chr3	49947848	49947848	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cacacgggcgtccaggcctcGccctcgcgaaaggacgagga	14	15	0	0	rs151189958		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:49947848G>A	uc003cxz.2	-	4	1500	c.1374C>T	c.(1372-1374)GGC>GGT	p.G458G	MON1A_uc003cya.2_Silent_p.G296G|MON1A_uc003cyb.2_Silent_p.G296G	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	361							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCCAGGCCTCGCCCTCGCGAA	0.597													0	0	0	0.004482	0	8	43										A	49947848	G	A	49947848	2	1	33	1	0	0	0	0	0	0	0	1	9698	1074	38	2		2	MON1A	3	49947848	Silent	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	1324040	49947848	148074582	8	8449										
FLNB	2317	broad.mit.edu	37	chr3	58154337	58154337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	acctgatcagcgtcaaatacGgtgggcccaaccacatcgtg	10	13	2	1	rs142229998		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:58154337G>A	uc003djj.2	+	44	7534	c.7369G>A	c.(7369-7371)GGT>AGT	p.G2457S	FLNB_uc010hne.2_Missense_Mutation_p.G2488S|FLNB_uc003djk.2_Missense_Mutation_p.G2446S|FLNB_uc010hnf.2_Missense_Mutation_p.G2433S|FLNB_uc003djl.2_Missense_Mutation_p.G2277S|FLNB_uc003djm.2_Missense_Mutation_p.G2264S|uc003djn.2_Intron	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2457	Filamin 23.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CGTCAAATACGGTGGGCCCAA	0.532													0	0	0	0.024245	0	13	48										A	58154337	G	A	58154337	3	1	33	1	0	0	0	0	1	0	0	0	5934	1116	39	2	7640	2	FLNB	3	58154337	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	8206489	58154337	139868093	9	8450										
PDZRN3	23024	broad.mit.edu	37	chr3	73433185	73433185	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ggcgtggggctccggctcccGtcgctggctctccgctcttt	14	16	2	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:73433185G>A	uc003dpl.1	-	10	2628	c.2532C>T	c.(2530-2532)GAC>GAT	p.D844D	PDZRN3_uc011bgh.1_Silent_p.D501D|PDZRN3_uc010hoe.1_Silent_p.D542D|PDZRN3_uc011bgf.1_Silent_p.D561D|PDZRN3_uc011bgg.1_Silent_p.D564D	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	844							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TCCGGCTCCCGTCGCTGGCTC	0.667													0	0	0	0.007291	0	28	38										A	73433185	G	A	73433185	2	1	33	1	0	0	0	0	0	0	0	1	11709	1136	40	2		2	PDZRN3	3	73433185	Silent	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	15278848	73433185	124589245	10	8451										
FXR1	8087	broad.mit.edu	37	chr3	180666136	180666136	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gtattttgatgtcttttagtTttatgtcattgaatatgctg	8	3	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr3:180666136T>A	uc003fkq.2	+	5	294	c.272T>A	c.(271-273)TTT>TAT	p.F91Y	FXR1_uc003fkp.2_Missense_Mutation_p.F6Y|FXR1_uc003fkr.2_Missense_Mutation_p.F91Y|FXR1_uc011bqj.1_Missense_Mutation_p.F5Y|FXR1_uc003fks.2_Missense_Mutation_p.F5Y|FXR1_uc011bqk.1_Missense_Mutation_p.F42Y|FXR1_uc011bql.1_Missense_Mutation_p.F78Y	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	91					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GTCTTTTAGTTTTATGTCATT	0.318													0	0	0	0.021553	0	4	25										A	180666136	T	A	180666136	3	1	33	1	0	0	0	0	1	0	0	0	6115	1855	64	5	290	5	FXR1	3	180666136	Missense_Mutation	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08	107232951	180666136	17356294	11	8452										
CDS1	1040	broad.mit.edu	37	chr4	85553028	85553028	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	attatcgtctgcagttttatAtggtgtgtattaactattat	7	4	1	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:85553028A>G	uc011ccv.1	+	6	1135	c.637A>G	c.(637-639)ATG>GTG	p.M213V	CDS1_uc010ike.1_Missense_Mutation_p.M17V	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	213					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GCAGTTTTATATGGTGTGTAT	0.338													0	0	0	0.006122	0	16	70										G	85553028	A	G	85553028	3	3	33	1	0	0	0	0	1	0	0	0	3177	449	16	5	659	5	CDS1	4	85553028	Missense_Mutation	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08		85553028	105601248	12	8453										
PLK4	10733	broad.mit.edu	37	chr4	128807800	128807800	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aggtactcacccacagacaaCaatgccaacatttttaactt	4	12	1	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:128807800C>A	uc003ifo.2	+	5	1520	c.1275C>A	c.(1273-1275)AAC>AAA	p.N425K	PLK4_uc011cgs.1_Missense_Mutation_p.N393K|PLK4_uc011cgt.1_Missense_Mutation_p.N384K	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	425					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CCACAGACAACAATGCCAACA	0.368													1	0	0.004672	0.004672	0.00485522	3	37										A	128807800	C	A	128807800	3	1	33	1	0	0	0	0	1	0	0	0	12098	477	17	4	1293	4	PLK4	4	128807800	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	43254772	128807800	62346476	13	8454										
TLR3	7098	broad.mit.edu	37	chr4	187005188	187005188	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aatggaaaaggaagaccaatCtctcaaattttgtctggaag	9	6	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr4:187005188C>G	uc003iyq.2	+	4	2449	c.2348C>G	c.(2347-2349)TCT>TGT	p.S783C	TLR3_uc011ckz.1_Missense_Mutation_p.S506C|TLR3_uc003iyr.2_Missense_Mutation_p.S506C	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	783	Cytoplasmic (Potential).|TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		GAAGACCAATCTCTCAAATTT	0.353													0	0	0	0.00499	0	17	61										G	187005188	C	G	187005188	3	3	33	1	0	0	0	0	1	0	0	0	15949	913	32	1	2358	1	TLR3	4	187005188	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	58197388	187005188	4149088	14	8455										
PAIP1	10605	broad.mit.edu	37	chr5	43556029	43556029	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	caaccacctggggcttagccAttgctgactccgagttctgc	10	14	1	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr5:43556029A>T	uc003job.2	-	2	585	c.338T>A	c.(337-339)ATG>AAG	p.M113K	PAIP1_uc003joa.2_Missense_Mutation_p.M34K|PAIP1_uc010ivp.2_Missense_Mutation_p.M34K|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.M1K	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	113					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					GGGCTTAGCCATTGCTGACTC	0.473													0	0	0	0.01441	0	62	60										T	43556029	A	T	43556029	3	4	33	1	0	0	0	0	1	0	0	0	11396	217	8	5	1141	5	PAIP1	5	43556029	Missense_Mutation	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08		43556029	137359231	15	8456										
ATXN1	6310	broad.mit.edu	37	chr6	16327275	16327275	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tgagagcgcgtaggaccggtGgccaggcttccctaaatgca	14	11	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:16327275G>A	uc003nbt.2	-	8	2238	c.1267C>T	c.(1267-1269)CAC>TAC	p.H423Y	ATXN1_uc010jpi.2_Missense_Mutation_p.H423Y|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	423					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TAGGACCGGTGGCCAGGCTTC	0.622													0	0	0	0.01441	0	75	80										A	16327275	G	A	16327275	3	1	33	1	0	0	0	0	1	0	0	0	1209	1348	47	2	1188	2	ATXN1	6	16327275	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		16327275	154787792	16	8457										
TCTE1	202500	broad.mit.edu	37	chr6	44255546	44255546	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ggtccaacaatgctgatgtcGttacggtatcctgcatgctg	11	10	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:44255546G>A	uc003oxi.2	-	2	173	c.17C>T	c.(16-18)ACG>ATG	p.T6M	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	6										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCTGATGTCGTTACGGTATC	0.557													0	0	0	0.004482	0	6	24										A	44255546	G	A	44255546	3	1	33	1	0	0	0	0	1	0	0	0	15714	1145	40	2	1504	2	TCTE1	6	44255546	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	27928271	44255546	126859521	17	8458										
C6orf174	387104	broad.mit.edu	37	chr6	127796588	127796588	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tgctcccggatgcggctgccGtcgtcctcctcgtccatgag	12	16	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:127796588G>A	uc003qbd.2	-	6	3448	c.2583C>T	c.(2581-2583)GAC>GAT	p.D861D	C6orf174_uc003qbc.2_Translation_Start_Site	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	861						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TGCGGCTGCCGTCGTCCTCCT	0.642													0	0	0	0.024334	0	25	47										A	127796588	G	A	127796588	2	1	33	1	0	0	0	0	0	0	0	1	2345	1136	40	2		2	C6orf174	6	127796588	Silent	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	83541042	127796588	43318479	18	8459										
GRM1	2911	broad.mit.edu	37	chr6	146720574	146720574	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cacctgtatcatctggctagCttttgtgcccatttactttg	7	11	2	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:146720574C>A	uc010khw.1	+	8	2869	c.2399C>A	c.(2398-2400)GCT>GAT	p.A800D	GRM1_uc010khv.1_Missense_Mutation_p.A800D|GRM1_uc003qll.2_Missense_Mutation_p.A800D|GRM1_uc011edz.1_Missense_Mutation_p.A800D|GRM1_uc011eea.1_Missense_Mutation_p.A800D	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	800	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATCTGGCTAGCTTTTGTGCCC	0.493													1	0	2.47511e-08	0.008361	2.67716e-08	26	69										A	146720574	C	A	146720574	3	1	33	1	0	0	0	0	1	0	0	0	6796	797	28	4	2425	4	GRM1	6	146720574	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	18923986	146720574	24394493	19	8460										
STXBP5	134957	broad.mit.edu	37	chr6	147527160	147527160	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gccctggcctttgatcctgtAcagaagatcctggcagtggg	13	11	0	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:147527160A>G	uc003qlz.2	+	2	365	c.204A>G	c.(202-204)GTA>GTG	p.V68V	uc003qlt.1_5'Flank|uc003qlu.1_5'Flank|STXBP5_uc010khz.1_Silent_p.V68V|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_5'UTR	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	68	WD 1.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TTGATCCTGTACAGAAGATCC	0.463													0	0	0	0.007835	0	35	25										G	147527160	A	G	147527160	2	3	33	1	0	0	0	0	0	0	0	1	15355	378	14	5		5	STXBP5	6	147527160	Silent	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08	806586	147527160	23587907	20	8461										
SYNE1	23345	broad.mit.edu	37	chr6	152675920	152675920	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aacttttgctccattagcctCaatttgttcaccacgttatt	4	11	2	0	rs114858512	byFrequency	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:152675920C>T	uc010kiw.2	-	67	11402	c.10800G>A	c.(10798-10800)TTG>TTA	p.L3600L	SYNE1_uc003qot.3_Silent_p.L3607L|SYNE1_uc003qou.3_Silent_p.L3600L|SYNE1_uc010kja.1_Silent_p.L305L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3600	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCATTAGCCTCAATTTGTTCA	0.502										HNSCC(10;0.0054)			0	0	0	0.00499	0	17	60										T	152675920	C	T	152675920	2	4	33	1	0	0	0	0	0	0	0	1	15442	825	29	1		1	SYNE1	6	152675920	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	5148760	152675920	18439147	21	8462										
GPR31	2853	broad.mit.edu	37	chr6	167570440	167570440	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gagggtgtggaagaccctccGataggagctcctgaaggtgg	17	8	0	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr6:167570440G>A	uc011egq.1	-	1	880	c.880C>T	c.(880-882)CGG>TGG	p.R294W		NM_005299	NP_005290	O00270	GPR31_HUMAN	G protein-coupled receptor 31	294	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		AAGACCCTCCGATAGGAGCTC	0.597													0	0	0	0.004672	0	3	33										A	167570440	G	A	167570440	3	1	33	1	0	0	0	0	1	0	0	0	6687	1057	37	1	82	1	GPR31	6	167570440	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	14894520	167570440	3544627	22	8463										
ZNF716	441234	broad.mit.edu	37	chr7	57522240	57522240	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tgcctggatcatgctcagcaGaatttatatagagatgtgat	10	6	2	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:57522240G>T	uc011kdi.1	+	2	226	c.114G>T	c.(112-114)CAG>CAT	p.Q38H		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						ATGCTCAGCAGAATTTATATA	0.373													1	0	0.000274275	0.004482	0.000293668	5	57										T	57522240	G	T	57522240	3	4	33	1	0	0	0	0	1	0	0	0	18116	933	33	3	120	3	ZNF716	7	57522240	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		57522240	101616423	23	8464										
SPDYE3	441272	broad.mit.edu	37	chr7	99917269	99917269	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ctgtacgggaagacccactcTcacatacccttgcgccctaa	7	16	1	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:99917269T>C	uc003uug.1	+	4	537	c.297T>C	c.(295-297)TCT>TCC	p.S99S	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	476											0						AGACCCACTCTCACATACCCT	0.532													0	0	0	0.01892	0	24	57										C	99917269	T	C	99917269	2	2	33	1	0	0	0	0	0	0	0	1	15029	1538	54	5		5	SPDYE3	7	99917269	Silent	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08	42395029	99917269	59221394	24	8465										
PILRB	29990	broad.mit.edu	37	chr7	99956513	99956514	+	Frame_Shift_Ins	INS	-	-	T													0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cagcacaaggccgccttccaINSttcacaaggattatgtgaac							TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:99956513_99956514insT	uc003uuk.2	+	16	2761_2762	c.265_266insT	c.(265-267)ATTfs	p.I89fs	PILRB_uc003uul.2_Intron|PILRB_uc003uum.1_RNA|PILRB_uc003uun.2_Frame_Shift_Ins_p.I89fs	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	89	Extracellular (Potential).|Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCGCCTTCCATTCACAAGGAT	0.55																		53	105	---	---								T	99956514	-	T	99956513	7	5	33	1	0	1	1	0	0	0	0	0	11926	217	8	0	271	0	PILRB	7	99956513	Frame_Shift_Ins	INS	-	TCGA-CF-A3MI-01A-11D-A20D-08	39244	99956513	59182150	25	8466										
ASB15	142685	broad.mit.edu	37	chr7	123269135	123269135	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ttggcgtttctaataatgacGttcattgcacagaagtcctt	8	8	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:123269135G>A	uc003vku.1	+	10	1379	c.1087G>A	c.(1087-1089)GTT>ATT	p.V363I	ASB15_uc003vkw.1_Missense_Mutation_p.V363I	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	363	ANK 7.				intracellular signal transduction					skin(2)|lung(1)	3						TAATAATGACGTTCATTGCAC	0.438													0	0	0	0.021022	0	35	41										A	123269135	G	A	123269135	3	1	33	1	0	0	0	0	1	0	0	0	1019	1145	40	2	1113	2	ASB15	7	123269135	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	23312622	123269135	35869528	26	8467										
ZNF212	7988	broad.mit.edu	37	chr7	148950982	148950982	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cctacgaatgttctgagtgtGagatcaccttccgctataag	9	10	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:148950982G>C	uc003wfp.2	+	5	1060	c.964G>C	c.(964-966)GAG>CAG	p.E322Q		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	322	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			TTCTGAGTGTGAGATCACCTT	0.567													0	0	0	0.009096	0	4	43										C	148950982	G	C	148950982	3	2	33	1	0	0	0	0	1	0	0	0	17765	1291	45	1	982	1	ZNF212	7	148950982	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	25681847	148950982	10187681	27	8468										
MLL3	58508	broad.mit.edu	37	chr7	151962241	151962241	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	acaagtagtacaaaagaactGatctaagaggtctcccgggc	10	9	2	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr7:151962241G>C	uc003wla.2	-	8	1285	c.1066C>G	c.(1066-1068)CAG>GAG	p.Q356E		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	356	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAAAAGAACTGATCTAAGAGG	0.413			N		medulloblastoma								0	0	0	0.028581	0	12	271										C	151962241	G	C	151962241	3	2	33	1	0	0	0	0	1	0	0	0	9622	1299	45	1	13877	1	MLL3	7	151962241	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	3011259	151962241	7176422	28	8469										
TEX15	56154	broad.mit.edu	37	chr8	30704505	30704505	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ttctaattctatttcaatttCactttccaattcaatgctct	1	10	6	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:30704505C>T	uc003xil.2	-	1	2029	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	677										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATTTCAATTTCACTTTCCAAT	0.289													0	0	0	0.00308	0	6	19										T	30704505	C	T	30704505	3	4	33	1	0	0	0	0	1	0	0	0	15776	835	29	1	6356	1	TEX15	8	30704505	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		30704505	115659517	29	8470										
CYP11B2	1585	broad.mit.edu	37	chr8	143994845	143994845	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tccgagccagctcaaagagcGtcatcagcaagggaaacgct	11	12	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr8:143994845G>A	uc003yxk.1	-	6	980	c.977C>T	c.(976-978)ACG>ATG	p.T326M		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	326					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CTCAAAGAGCGTCATCAGCAA	0.627									Familial_Hyperaldosteronism_type_I				0	0	0	0.01441	0	43	69										A	143994845	G	A	143994845	3	1	33	1	0	0	0	0	1	0	0	0	4146	1145	40	2	550	2	CYP11B2	8	143994845	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	113290340	143994845	2369177	30	8471										
RFX3	5991	broad.mit.edu	37	chr9	3277363	3277363	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aaaactgttgatgatgttggCtttgggcaattacagtttgc	11	5	0	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:3277363C>T	uc003zhr.2	-	9	1262	c.950G>A	c.(949-951)AGC>AAC	p.S317N	RFX3_uc010mhd.2_Missense_Mutation_p.S317N|RFX3_uc003zhs.1_Missense_Mutation_p.S317N|RFX3_uc003zht.1_Missense_Mutation_p.S317N|RFX3_uc010mhe.1_Missense_Mutation_p.S292N	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	317					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		ATGATGTTGGCTTTGGGCAAT	0.403													0	0	0	0.013726	0	32	67										T	3277363	C	T	3277363	3	4	33	1	0	0	0	0	1	0	0	0	13264	797	28	2	1495	2	RFX3	9	3277363	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		3277363	137936068	31	8472										
CEP110	11064	broad.mit.edu	37	chr9	123921142	123921142	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ctttaatacaggtgacaagtCagcagcaggagatggctgtc	12	8	1	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:123921142C>T	uc004bkx.1	+	29	4805	c.4774C>T	c.(4774-4776)CAG>TAG	p.Q1592*	CEP110_uc010mvo.1_Nonsense_Mutation_p.Q261*|CEP110_uc004blb.1_Nonsense_Mutation_p.Q261*|CEP110_uc010mvp.1_Intron	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1592	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GGTGACAAGTCAGCAGCAGGA	0.463													0	0	0	0.01441	0	70	13										T	123921142	C	T	123921142	4	4	33	1	0	0	0	0	0	1	0	0	3245	827	29	1	4888	1	CEP110	9	123921142	Nonsense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	120643779	123921142	17292289	32	8473										
ARPC5L	81873	broad.mit.edu	37	chr9	127637310	127637310	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aacttcaagagcagtgagatTgagcaggctgtgcagtcact	12	8	2	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:127637310T>C	uc004bpa.3	+	3	365	c.279T>C	c.(277-279)ATT>ATC	p.I93I	ARPC5L_uc011lzq.1_Silent_p.I41I	NM_030978	NP_112240	Q9BPX5	ARP5L_HUMAN	actin related protein 2/3 complex, subunit	93					regulation of actin filament polymerization	cytoplasm|cytoskeleton	actin binding				0						GCAGTGAGATTGAGCAGGCTG	0.502													0	0	0	0.00308	0	5	90										C	127637310	T	C	127637310	2	2	33	1	0	0	0	0	0	0	0	1	975	1800	63	5		5	ARPC5L	9	127637310	Silent	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08	3716168	127637310	13576121	33	8474										
TTC16	158248	broad.mit.edu	37	chr9	130485503	130485503	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tggcccaggcccagcaggcgCgccaagatgcggggatcctg	16	14	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:130485503C>T	uc004brq.1	+	7	830	c.763C>T	c.(763-765)CGC>TGC	p.R255C	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Missense_Mutation_p.R242C|TTC16_uc004brr.1_Missense_Mutation_p.R200C|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	255	TPR 4.						binding				0						CCAGCAGGCGCGCCAAGATGC	0.642													0	0	0	0.013114	0	45	6										T	130485503	C	T	130485503	3	4	33	1	0	0	0	0	1	0	0	0	16680	768	27	2	789	2	TTC16	9	130485503	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	2848193	130485503	10727928	34	8475										
LRRC8A	56262	broad.mit.edu	37	chr9	131669702	131669702	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cctaccccaactccaccattCtgccgacccctgacacgggc	6	21	1	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131669702C>T	uc004bwl.3	+	3	513	c.259C>T	c.(259-261)CTG>TTG	p.L87L	LRRC8A_uc010myp.2_Silent_p.L87L|LRRC8A_uc010myq.2_Silent_p.L87L	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	87					pre-B cell differentiation	integral to membrane					0						CTCCACCATTCTGCCGACCCC	0.617													0	0	0	0.01441	0	59	10										T	131669702	C	T	131669702	2	4	33	1	0	0	0	0	0	0	0	1	9021	912	32	1		1	LRRC8A	9	131669702	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	1184199	131669702	9543729	35	8476			1	27		3	3	1380	C		6.97829e-06
LRRC8A	56262	broad.mit.edu	37	chr9	131670421	131670421	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	atcctggcgtccttctacatCagcctagtcatcttctacgg	7	14	5	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131670421C>T	uc004bwl.3	+	3	1232	c.978C>T	c.(976-978)ATC>ATT	p.I326I	LRRC8A_uc010myp.2_Silent_p.I326I|LRRC8A_uc010myq.2_Silent_p.I326I	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	326	Helical; (Potential).				pre-B cell differentiation	integral to membrane					0						CCTTCTACATCAGCCTAGTCA	0.567													0	0	0	0.01441	0	71	11										T	131670421	C	T	131670421	2	4	33	1	0	0	0	0	0	0	0	1	9021	816	29	1		1	LRRC8A	9	131670421	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	719	131670421	9543010	36	8477			1	27		3	3	1380	C		6.97829e-06
LRRC8A	56262	broad.mit.edu	37	chr9	131671081	131671081	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ctgcgggagctcaaacgcctCaaggtgctgcggctcaagag	14	12	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:131671081C>G	uc004bwl.3	+	3	1892	c.1638C>G	c.(1636-1638)CTC>CTG	p.L546L	LRRC8A_uc010myp.2_Silent_p.L546L|LRRC8A_uc010myq.2_Silent_p.L546L	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	546	LRR 8.				pre-B cell differentiation	integral to membrane					0						TCAAACGCCTCAAGGTGCTGC	0.592													0	0	0	0.007291	0	28	4										G	131671081	C	G	131671081	2	3	33	1	0	0	0	0	0	0	0	1	9021	813	29	1		1	LRRC8A	9	131671081	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	660	131671081	9542350	37	8478			1	27		3	3	1380	C		6.97829e-06
USP20	10868	broad.mit.edu	37	chr9	132620365	132620365	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ttggctgcggagaatcctttGctgaccacagcaccattcat	9	12	1	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr9:132620365G>A	uc004bys.2	+	5	383	c.172G>A	c.(172-174)GCT>ACT	p.A58T	USP20_uc004byr.2_Missense_Mutation_p.A58T|USP20_uc004byt.1_Missense_Mutation_p.A58T	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	58	UBP-type.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				AGAATCCTTTGCTGACCACAG	0.368													0	0	0	0.010771	0	37	51										A	132620365	G	A	132620365	3	1	33	1	0	0	0	0	1	0	0	0	17049	1319	46	2	182	2	USP20	9	132620365	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	949284	132620365	8593066	38	8479										
FAM188A	80013	broad.mit.edu	37	chr10	15863726	15863726	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ttcatgtataccaagaagttCtgcaaaaaacaacaacaaca	4	9	2	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:15863726C>T	uc001iod.1	-	9	952	c.731_splice	c.e9-1	p.K244_splice	FAM188A_uc001ioe.1_Splice_Site_p.K71_splice|FAM188A_uc001iof.1_Splice_Site_p.K244_splice	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97						apoptosis	nucleus	calcium ion binding			ovary(1)	1						CCAAGAAGTTCTGCAAAAAAC	0.289													0	0	0	0.004482	0	8	28										T	15863726	C	T	15863726	5	4	33	1	0	0	0	0	0	0	1	0	5514	927	32	1	635	1	FAM188A	10	15863726	Splice_Site	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		15863726	119671021	39	8480										
SPAG6	9576	broad.mit.edu	37	chr10	22690092	22690093	+	Frame_Shift_Ins	INS	-	-	A													0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ctgctttgtatttctagagtINSaaaaaagccataaagaatat							TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:22690092_22690093insA	uc001iri.2	+	9	1342_1343	c.1200_1201insA	c.(1198-1203)AGTAAAfs	p.S400fs	SPAG6_uc001irj.2_Frame_Shift_Ins_p.S400fs|SPAG6_uc010qct.1_Frame_Shift_Ins_p.S370fs|SPAG6_uc009xkh.2_Frame_Shift_Ins_p.S378fs	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	400_401	ARM 8.				cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						ATTTCTAGAGTAAAAAAGCCAT	0.327																		16	49	---	---								A	22690093	-	A	22690092	7	5	33	1	0	1	1	0	0	0	0	0	14982	1635	57	0	1234	0	SPAG6	10	22690092	Frame_Shift_Ins	INS	-	TCGA-CF-A3MI-01A-11D-A20D-08	6826366	22690092	112844655	40	8481										
FBXW4	6468	broad.mit.edu	37	chr10	103454358	103454360	+	In_Frame_Del	DEL	CCT	CCT	-													0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ggcagccgactcccgagccgCctcctcctcctcctcctcct							TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr10:103454358_103454360delCCT	uc001kto.2	-	1	384_386	c.38_40delAGG	c.(37-42)GAGGCG>GCG	p.E13del		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	13					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TCCCGAGCCGcctcctcctcctc	0.675																		2	4	---	---								-	103454360	CCT	-	103454358	7	5	33	1	0	1	0	1	0	0	0	0	5767	739	26	0	1234	0	FBXW4	10	103454358	In_Frame_Del	DEL	CCT	TCGA-CF-A3MI-01A-11D-A20D-08	80764266	103454358	32080389	41	8482										
HRAS	3265	broad.mit.edu	37	chr11	534286	534286	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cagcgcactcttgcccacacCgccggcgcccaccaccacca	7	23	1	0	rs104894228		TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:534286C>G	uc001lpv.2	-	2	225	c.37G>C	c.(37-39)GGT>CGT	p.G13R	HRAS_uc010qvw.1_Missense_Mutation_p.G13R|HRAS_uc010qvx.1_Missense_Mutation_p.G13R|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(34)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.006122	0	18	10										G	534286	C	G	534286	3	3	33	1	0	0	0	0	1	0	0	0	7348	652	23	4	615	4	HRAS	11	534286	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		534286	134472230	42	8483										
TRIM68	55128	broad.mit.edu	37	chr11	4621770	4621770	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cggtactcatttcccttcctCagccttatcacccagaatcc	4	17	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:4621770C>G	uc001lzf.1	-	7	1432	c.1194G>C	c.(1192-1194)CTG>CTC	p.L398L	TRIM68_uc001lzg.1_Silent_p.L175L|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	398	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTCCCTTCCTCAGCCTTATCA	0.557													0	0	0	0.020292	0	12	41										G	4621770	C	G	4621770	2	3	33	1	0	0	0	0	0	0	0	1	16538	813	29	1		1	TRIM68	11	4621770	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	4087484	4621770	130384746	43	8484										
C11orf58	10944	broad.mit.edu	37	chr11	16774368	16774368	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aattaatgaagaactggagtCtcaatatcagcaaagtatgg	9	5	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:16774368C>G	uc001mmk.2	+	4	423	c.245C>G	c.(244-246)TCT>TGT	p.S82C	C11orf58_uc010rct.1_Missense_Mutation_p.S38C	NM_014267	NP_055082	O00193	SMAP_HUMAN	small acidic protein isoform a	82											0						GAACTGGAGTCTCAATATCAG	0.348													0	0	0	0.013114	0	42	7										G	16774368	C	G	16774368	3	3	33	1	0	0	0	0	1	0	0	0	1651	913	32	1	259	1	C11orf58	11	16774368	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	12152598	16774368	118232148	44	8485										
PTPRJ	5795	broad.mit.edu	37	chr11	48158582	48158582	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	caatgtgtccaacattgatgTaagtaccaacaccacagcag	7	11	0	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:48158582T>C	uc001ngp.3	+	10	2256	c.1901T>C	c.(1900-1902)GTA>GCA	p.V634A	PTPRJ_uc010rhr.1_Missense_Mutation_p.V79A	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	634	Extracellular (Potential).|Fibronectin type-III 7.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						AACATTGATGTAAGTACCAAC	0.408													0	0	0	0.00499	0	12	52										C	48158582	T	C	48158582	3	2	33	1	0	0	0	0	1	0	0	0	12804	1638	57	5	1948	5	PTPRJ	11	48158582	Missense_Mutation	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08	31384214	48158582	86847934	45	8486										
OR5D13	390142	broad.mit.edu	37	chr11	55541619	55541619	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	agatgcgatctgcaagtgggCgccagaaaactttctccacc	10	12	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:55541619C>T	uc010ril.1	+	1	706	c.706C>T	c.(706-708)CGC>TGC	p.R236C		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TGCAAGTGGGCGCCAGAAAAC	0.408													0	0	0	0.016522	0	19	58										T	55541619	C	T	55541619	3	4	33	1	0	0	0	0	1	0	0	0	11154	768	27	2	708	2	OR5D13	11	55541619	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	7383037	55541619	79464897	46	8487										
MARK2	2011	broad.mit.edu	37	chr11	63668273	63668276	+	Frame_Shift_Del	DEL	ATGA	ATGA	-													0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aaatcatgaaagatcgatggAtgaatgtgggtcacgaagat							TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:63668273_63668276delATGA	uc001nxw.2	+	10	1489_1492	c.910_913delATGA	c.(910-915)ATGAATfs	p.M304fs	MARK2_uc001nxx.2_Frame_Shift_Del_p.M304fs|MARK2_uc001nxy.2_Frame_Shift_Del_p.M304fs|MARK2_uc001nxv.3_Frame_Shift_Del_p.M304fs|MARK2_uc001nxz.3_Frame_Shift_Del_p.M271fs|MARK2_uc009yoy.2_Frame_Shift_Del_p.M271fs	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	304_305					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						AGATCGATGGATGAATGTGGGTCA	0.564																		95	144	---	---								-	63668276	ATGA	-	63668273	7	5	33	1	0	1	0	1	0	0	0	0	9313	333	12	0	948	0	MARK2	11	63668273	Frame_Shift_Del	DEL	ATGA	TCGA-CF-A3MI-01A-11D-A20D-08	8126654	63668273	71338243	47	8488										
ARAP1	116985	broad.mit.edu	37	chr11	72412694	72412694	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gagtctggggtggcacccacCttcccgggcccggcggtcct	15	16	1	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:72412694C>G	uc001osu.2	-	16	2491	c.2302G>C	c.(2302-2304)GAG>CAG	p.E768Q	ARAP1_uc001osv.2_Missense_Mutation_p.E768Q|ARAP1_uc001osr.2_Missense_Mutation_p.E528Q|ARAP1_uc001oss.2_Missense_Mutation_p.E523Q|ARAP1_uc009yth.2_Missense_Mutation_p.E462Q|ARAP1_uc010rre.1_Missense_Mutation_p.E523Q|ARAP1_uc001osw.1_Missense_Mutation_p.E56Q	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	768	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TGGCACCCACCTTCCCGGGCC	0.632													0	0	0	0.028581	0	15	120										G	72412694	C	G	72412694	3	3	33	1	0	0	0	0	1	0	0	0	838	695	24	4	2130	4	ARAP1	11	72412694	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	8744421	72412694	62593822	48	8489										
SORL1	6653	broad.mit.edu	37	chr11	121481797	121481797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gttttcagtgatcccaccacCagatatccacattgacagct	6	13	1	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:121481797C>T	uc001pxx.2	+	39	5332	c.5252C>T	c.(5251-5253)CCA>CTA	p.P1751L	SORL1_uc010rzp.1_Missense_Mutation_p.P597L|SORL1_uc010rzq.1_Missense_Mutation_p.P366L	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1751	Extracellular (Potential).|Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ATCCCACCACCAGATATCCAC	0.418													0	0	0	0.012213	0	29	55										T	121481797	C	T	121481797	3	4	33	1	0	0	0	0	1	0	0	0	14934	594	21	2	5406	2	SORL1	11	121481797	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	49069103	121481797	13524719	49	8490										
C11orf63	79864	broad.mit.edu	37	chr11	122756598	122756598	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tcccaagctctctattcaatCtcctgtccttcataccaact	2	16	4	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr11:122756598C>A	uc001pym.2	+	2	338	c.41C>A	c.(40-42)TCT>TAT	p.S14Y	C11orf63_uc001pyl.1_Missense_Mutation_p.S14Y	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	14										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TCTATTCAATCTCCTGTCCTT	0.393													1	0	4.26978e-12	0.01892	4.71455e-12	21	63										A	122756598	C	A	122756598	3	1	33	1	0	0	0	0	1	0	0	0	1654	913	32	3	43	3	C11orf63	11	122756598	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	1274801	122756598	12249918	50	8491										
ARID2	196528	broad.mit.edu	37	chr12	46245523	46245523	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aggaattaccatgagcggaaCgcagacaggagttggacttc	13	8	0	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:46245523C>T	uc001ros.1	+	15	3617	c.3617C>T	c.(3616-3618)ACG>ATG	p.T1206M	ARID2_uc001ror.2_Missense_Mutation_p.T1206M|ARID2_uc009zkg.1_Missense_Mutation_p.T662M|ARID2_uc009zkh.1_Missense_Mutation_p.T833M|ARID2_uc001rou.1_Missense_Mutation_p.T540M	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1206					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATGAGCGGAACGCAGACAGGA	0.488													0	0	0	0.016723	0	13	15										T	46245523	C	T	46245523	3	4	33	1	0	0	0	0	1	0	0	0	915	536	19	2	3675	2	ARID2	12	46245523	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		46245523	87606372	51	8492										
HOXC13	3229	broad.mit.edu	37	chr12	54339012	54339012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gaagaaggtggtcagcaaatCgaaagcgcctcatctccact	10	11	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:54339012C>T	uc001sei.2	+	2	1080	c.965C>T	c.(964-966)TCG>TTG	p.S322L	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	322						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GTCAGCAAATCGAAAGCGCCT	0.577			T	NUP98	AML								0	0	0	0.016723	0	13	189										T	54339012	C	T	54339012	3	4	33	1	0	0	0	0	1	0	0	0	7312	893	31	1	971	1	HOXC13	12	54339012	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	8093489	54339012	79512883	52	8493										
UBE3B	89910	broad.mit.edu	37	chr12	109927742	109927742	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aggtgaaagtcttcgaccagCgatgaaccacatttgtgcaa	10	9	1	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:109927742C>T	uc001top.2	+	8	1166	c.563C>T	c.(562-564)GCG>GTG	p.A188V	UBE3B_uc001toq.2_Missense_Mutation_p.A188V|UBE3B_uc001tol.1_Missense_Mutation_p.A188V|UBE3B_uc001tom.2_Missense_Mutation_p.A188V|UBE3B_uc001ton.2_Missense_Mutation_p.A188V|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.A188V|UBE3B_uc001tor.2_Missense_Mutation_p.A188V	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	188					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CTTCGACCAGCGATGAACCAC	0.443													0	0	0	0.00499	0	15	188										T	109927742	C	T	109927742	3	4	33	1	0	0	0	0	1	0	0	0	16877	768	27	2	585	2	UBE3B	12	109927742	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	55588730	109927742	23924153	53	8494										
KDM2B	84678	broad.mit.edu	37	chr12	121882333	121882333	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gttgaccacaccctctgactCcttaatctgcggggaacacc	8	15	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr12:121882333C>A	uc001uat.2	-	15	2214	c.2110G>T	c.(2110-2112)GAG>TAG	p.E704*	KDM2B_uc001uaq.2_Nonsense_Mutation_p.E144*|KDM2B_uc010szy.1_Nonsense_Mutation_p.E144*|KDM2B_uc001uar.2_Nonsense_Mutation_p.E295*|KDM2B_uc001uas.2_Nonsense_Mutation_p.E673*|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_5'Flank|KDM2B_uc010szx.1_5'Flank|KDM2B_uc001uap.2_5'Flank	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	704	PHD-type.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTCTGACTCCTTAATCTGC	0.602													1	0	0.00400662	0.028581	0.00420497	14	101										A	121882333	C	A	121882333	4	1	33	1	0	0	0	0	0	1	0	0	8125	864	30	3	1988	3	KDM2B	12	121882333	Nonsense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	11954591	121882333	11969562	54	8495										
OTUD7A	161725	broad.mit.edu	37	chr15	31818621	31818621	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aggccagcttcagcagctccGtccactcccgctcccactcc	7	21	1	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:31818621G>A	uc001zfq.2	-	6	896	c.803C>T	c.(802-804)ACG>ATG	p.T268M	OTUD7A_uc001zfr.2_Missense_Mutation_p.T275M	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	268	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CAGCAGCTCCGTCCACTCCCG	0.682													0	0	0	0.004482	0	7	35										A	31818621	G	A	31818621	3	1	33	1	0	0	0	0	1	0	0	0	11318	1145	40	2	2001	2	OTUD7A	15	31818621	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		31818621	70712771	55	8496										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32929352	32929352	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gtcattggaaacatgtgagaAaacagtttctgaaagttcac	9	6	3	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:32929352A>T	uc001zgy.1	+	12	3100	c.2378A>T	c.(2377-2379)AAA>ATA	p.K793I	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.K604I|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.K604I	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	793					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		ACATGTGAGAAAACAGTTTCT	0.348													0	0	0	0.024245	0	14	49										T	32929352	A	T	32929352	3	4	33	1	0	0	0	0	1	0	0	0	863	14	1	5	2447	5	ARHGAP11A	15	32929352	Missense_Mutation	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08	1110731	32929352	69602040	56	8497										
WDR72	256764	broad.mit.edu	37	chr15	53994342	53994342	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tcgtcttactttaaacttctCtggtgacatcaaaagacttg	6	9	3	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:53994342C>T	uc002acj.2	-	12	1600	c.1558G>A	c.(1558-1560)GAG>AAG	p.E520K	WDR72_uc010bfi.1_Missense_Mutation_p.E520K	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	520	WD 7.									lung(1)|skin(1)	2				all cancers(107;0.0511)		TTAAACTTCTCTGGTGACATC	0.294													0	0	0	0.010729	0	10	64										T	53994342	C	T	53994342	3	4	33	1	0	0	0	0	1	0	0	0	17319	922	32	1	1786	1	WDR72	15	53994342	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	21064990	53994342	48537050	57	8498										
LDHAL6B	92483	broad.mit.edu	37	chr15	59499546	59499546	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	caaagattactttgtcacagCaaactccaacctagtgatta	5	10	1	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:59499546C>G	uc002agb.2	+	1	505	c.407C>G	c.(406-408)GCA>GGA	p.A136G	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	136					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	TTTGTCACAGCAAACTCCAAC	0.433													0	0	0	0.027356	0	26	80										G	59499546	C	G	59499546	3	3	33	1	0	0	0	0	1	0	0	0	8700	710	25	4	409	4	LDHAL6B	15	59499546	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	5505204	59499546	43031846	58	8499										
CYP11A1	1583	broad.mit.edu	37	chr15	74637457	74637457	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ggagcccgccttcttgatgcGcctgtgcaggacactgacga	13	13	1	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr15:74637457G>A	uc002axt.2	-	3	708	c.553C>T	c.(553-555)CGC>TGC	p.R185C	CYP11A1_uc002axs.2_Missense_Mutation_p.R27C|CYP11A1_uc010bjm.1_Missense_Mutation_p.R27C|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Missense_Mutation_p.R185C|CYP11A1_uc010bjp.1_5'Flank|CYP11A1_uc010ulj.1_Intron|CYP11A1_uc010bjq.2_Missense_Mutation_p.R185C	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	185					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	TTCTTGATGCGCCTGTGCAGG	0.582													0	0	0	0.014758	0	4	69										A	74637457	G	A	74637457	3	1	33	1	0	0	0	0	1	0	0	0	4144	1087	38	2	1040	2	CYP11A1	15	74637457	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	15137911	74637457	27893935	59	8500										
RBBP6	5930	broad.mit.edu	37	chr16	24573026	24573026	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tgctttaattgccaataaatTtttacgacaggtaactgtct	6	7	1	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:24573026T>G	uc002dmh.2	+	9	1981	c.941T>G	c.(940-942)TTT>TGT	p.F314C	RBBP6_uc010vcb.1_Missense_Mutation_p.F181C|RBBP6_uc002dmi.2_Missense_Mutation_p.F314C|RBBP6_uc010bxr.2_Missense_Mutation_p.F314C|RBBP6_uc002dmk.2_Missense_Mutation_p.F181C	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	314					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GCCAATAAATTTTTACGACAG	0.333													0	0	0	0.014758	0	5	60										G	24573026	T	G	24573026	3	3	33	1	0	0	0	0	1	0	0	0	13103	1841	64	5	1029	5	RBBP6	16	24573026	Missense_Mutation	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08		24573026	65781727	60	8501										
ZNF629	23361	broad.mit.edu	37	chr16	30794836	30794836	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	atgaggtccgagctgcggtaGaaagcccggcggcactcgcc	15	13	0	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:30794836G>A	uc002dzs.1	-	3	1021	c.813C>T	c.(811-813)TTC>TTT	p.F271F		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	271	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			AGCTGCGGTAGAAAGCCCGGC	0.632													0	0	0	0.020292	0	13	33										A	30794836	G	A	30794836	2	1	33	1	0	0	0	0	0	0	0	1	18050	933	33	1		1	ZNF629	16	30794836	Silent	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	6221810	30794836	59559917	61	8502										
CMTM2	146225	broad.mit.edu	37	chr16	66621938	66621938	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cctcctccaggaaaggaaaaAggaccccagcagggcaaggg	13	12	0	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:66621938A>G	uc002ept.2	+	4	823	c.663A>G	c.(661-663)AAA>AAG	p.K221K	CMTM2_uc010cdu.2_Silent_p.K168K	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	221					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		GAAAGGAAAAAGGACCCCAGC	0.522													0	0	0	0.004672	0	3	73										G	66621938	A	G	66621938	2	3	33	1	0	0	0	0	0	0	0	1	3583	69	3	5		5	CMTM2	16	66621938	Silent	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08	35827102	66621938	23732815	62	8503										
AP1G1	164	broad.mit.edu	37	chr16	71798289	71798289	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gacttaatatccatgatagtCaaaaccgtttcataaagaat	5	7	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr16:71798289C>G	uc010cgg.2	-	9	1196	c.882G>C	c.(880-882)TTG>TTC	p.L294F	AP1G1_uc002fba.2_Missense_Mutation_p.L297F|AP1G1_uc002fbb.2_Missense_Mutation_p.L317F|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	294					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				CCATGATAGTCAAAACCGTTT	0.363													0	0	0	0.00308	0	7	31										G	71798289	C	G	71798289	3	3	33	1	0	0	0	0	1	0	0	0	732	825	29	1	1646	1	AP1G1	16	71798289	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	5176351	71798289	18556464	63	8504										
GEMIN4	50628	broad.mit.edu	37	chr17	650821	650821	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aggaagaaggccacgtcttcGgcagaagtgtcaacggtcac	13	10	3	2	rs151264305	by1000genomes	TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:650821G>A	uc002frs.1	-	2	581	c.462C>T	c.(460-462)GCC>GCT	p.A154A	GEMIN4_uc010vqa.1_Silent_p.A154A	NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	154					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CCACGTCTTCGGCAGAAGTGT	0.567													0	0	0	0.00308	0	7	75										A	650821	G	A	650821	2	1	33	1	0	0	0	0	0	0	0	1	6330	1103	39	2		2	GEMIN4	17	650821	Silent	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		650821	80544389	64	8505										
DLG4	1742	broad.mit.edu	37	chr17	7094110	7094110	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	caccttgtggtagatctcctCaaagctgtcaccctccacga	7	15	3	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:7094110C>T	uc002get.3	-	22	3422	c.2221G>A	c.(2221-2223)GAG>AAG	p.E741K	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.E638K|DLG4_uc010cly.2_Missense_Mutation_p.E695K|DLG4_uc010vto.1_Missense_Mutation_p.E738K	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	698	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						TAGATCTCCTCAAAGCTGTCA	0.557													0	0	0	0.01892	0	23	58										T	7094110	C	T	7094110	3	4	33	1	0	0	0	0	1	0	0	0	4557	835	29	1	86	1	DLG4	17	7094110	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	6443289	7094110	74101100	65	8506										
MYH10	4628	broad.mit.edu	37	chr17	8393774	8393774	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cagacgaagcttggcatcttCcgtggcctggagttcgtctt	12	11	2	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:8393774C>G	uc002gll.2	-	33	4771	c.4675G>C	c.(4675-4677)GAA>CAA	p.E1559Q	MYH10_uc002glm.2_Missense_Mutation_p.E1590Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1568Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1559	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTGGCATCTTCCGTGGCCTGG	0.542													0	0	0	0.009096	0	3	96										G	8393774	C	G	8393774	3	3	33	1	0	0	0	0	1	0	0	0	10030	864	30	1	1291	1	MYH10	17	8393774	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	1299664	8393774	72801436	66	8507										
MYH10	4628	broad.mit.edu	37	chr17	8449973	8449973	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	ccaagaagatggcagagcttCtgcgcaactgaagtgtaaaa	11	8	1	4			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:8449973C>T	uc002gll.2	-	11	1233	c.1137G>A	c.(1135-1137)CAG>CAA	p.Q379Q	MYH10_uc002glm.2_Silent_p.Q389Q|MYH10_uc010cnx.2_Silent_p.Q388Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	379	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GGCAGAGCTTCTGCGCAACTG	0.418													0	0	0	0.010729	0	9	28										T	8449973	C	T	8449973	2	4	33	1	0	0	0	0	0	0	0	1	10030	912	32	1		1	MYH10	17	8449973	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	56199	8449973	72745237	67	8508										
MPRIP	23164	broad.mit.edu	37	chr17	17083384	17083384	+	Silent	SNP	C	C	T													0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tcctgtgtcacccggcaactCagaaacatcaggtccaaggt							TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:17083384C>T	uc002gqu.1	+	22	3083	c.3027C>T	c.(3025-3027)CTC>CTT	p.L1009L	MPRIP_uc002gqv.1_Silent_p.L1009L|MPRIP_uc002gqw.1_Silent_p.L764L|MPRIP_uc002gqx.1_Silent_p.L1238L|MPRIP_uc002gqy.1_Silent_p.L1238L|MPRIP_uc010cpl.1_Silent_p.L195L|MPRIP_uc010cpm.1_Silent_p.L195L	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	1009						cytoplasm|cytoskeleton	actin binding				0						CCCGGCAACTCAGAAACATCA	0.488													0	0	0	0.021553	0	5	25										T	17083384	C	T	17083384	2	4	33	1	0	0	0	0	0	0	0	1	9743	813	29	1		1	MPRIP	17	17083384	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	8633411	17083384	64111826	68	8509	40	2								
MPRIP	23164	broad.mit.edu	37	chr17	17083388	17083388	+	Missense_Mutation	SNP	A	A	C													0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gtgtcacccggcaactcagaAacatcaggtccaaggtgagt							TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:17083388A>C	uc002gqu.1	+	22	3087	c.3031A>C	c.(3031-3033)AAC>CAC	p.N1011H	MPRIP_uc002gqv.1_Missense_Mutation_p.N1011H|MPRIP_uc002gqw.1_Missense_Mutation_p.N766H|MPRIP_uc002gqx.1_Missense_Mutation_p.N1240H|MPRIP_uc002gqy.1_Missense_Mutation_p.N1240H|MPRIP_uc010cpl.1_Missense_Mutation_p.N197H|MPRIP_uc010cpm.1_Missense_Mutation_p.N197H	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	1011						cytoplasm|cytoskeleton	actin binding				0						GCAACTCAGAAACATCAGGTC	0.493													0	0	0	0.021553	0	5	25										C	17083388	A	C	17083388	3	2	33	1	0	0	0	0	1	0	0	0	9743	14	1	5	3117	5	MPRIP	17	17083388	Missense_Mutation	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08	4	17083388	64111822	69	8510	40	2								
ZNF207	7756	broad.mit.edu	37	chr17	30696342	30696342	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aagggcacagttacctaagtAtcaacgtaatcttcctcggc	8	11	2	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:30696342A>G	uc002hhh.3	+	10	1293	c.1145A>G	c.(1144-1146)TAT>TGT	p.Y382C	ZNF207_uc002hhj.3_Missense_Mutation_p.Y398C|ZNF207_uc002hhi.3_Missense_Mutation_p.Y367C|ZNF207_uc010csz.2_Missense_Mutation_p.Y401C|ZNF207_uc002hhk.1_Missense_Mutation_p.Y398C|ZNF207_uc002hhl.1_RNA	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	382						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTACCTAAGTATCAACGTAAT	0.502													0	0	0	0.007291	0	24	32										G	30696342	A	G	30696342	3	3	33	1	0	0	0	0	1	0	0	0	17762	449	16	5	1235	5	ZNF207	17	30696342	Missense_Mutation	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08	13612954	30696342	50498868	70	8511										
CDK5R1	8851	broad.mit.edu	37	chr17	30815244	30815244	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	atcacgccggccaacgtggtCttcctctacatgctctgcag	9	15	4	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:30815244C>T	uc002hhn.2	+	2	827	c.606C>T	c.(604-606)GTC>GTT	p.V202V	CDK5R1_uc010wca.1_Silent_p.V202V|CDK5R1_uc010ctc.2_Intron	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	202					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			CCAACGTGGTCTTCCTCTACA	0.642													0	0	0	0.020292	0	14	91										T	30815244	C	T	30815244	2	4	33	1	0	0	0	0	0	0	0	1	3143	900	32	1		1	CDK5R1	17	30815244	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	118902	30815244	50379966	71	8512										
TBX4	9496	broad.mit.edu	37	chr17	59534930	59534930	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	atcaaggtggggctgcatgaGaaggagctctggaagaagtt	16	5	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr17:59534930G>C	uc002izi.2	+	2	264	c.219G>C	c.(217-219)GAG>GAC	p.E73D	TBX4_uc010ddo.2_Missense_Mutation_p.E73D|TBX4_uc010woy.1_Missense_Mutation_p.E73D	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	73	T-box.				leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GGCTGCATGAGAAGGAGCTCT	0.597													0	0	0	0.004482	0	6	56										C	59534930	G	C	59534930	3	2	33	1	0	0	0	0	1	0	0	0	15657	933	33	1	225	1	TBX4	17	59534930	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	28719686	59534930	21660280	72	8513										
POLRMT	5442	broad.mit.edu	37	chr19	630113	630113	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	cgcgccacatccaccctgttCaccaccacctccgacacgct	5	22	1	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:630113C>T	uc002lpf.1	-	3	305	c.249G>A	c.(247-249)GTG>GTA	p.V83V		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	83					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCCTGTTCACCACCACCT	0.672													0	0	0	0.007413	0	18	86										T	630113	C	T	630113	2	4	33	1	0	0	0	0	0	0	0	1	12238	813	29	1		1	POLRMT	19	630113	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		630113	58498870	73	8514										
ATP8B3	148229	broad.mit.edu	37	chr19	1789016	1789016	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	taggaccagcggccgtgcacCagcaggaggcgctgcaggaa	16	12	0	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:1789016C>G	uc002ltw.2	-	24	3183	c.2949G>C	c.(2947-2949)CTG>CTC	p.L983L	ATP8B3_uc002ltv.2_Silent_p.L946L|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	983	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGTGCACCAGCAGGAGGC	0.632													0	0	0	0.021553	0	5	11										G	1789016	C	G	1789016	2	3	33	1	0	0	0	0	0	0	0	1	1196	581	21	4		4	ATP8B3	19	1789016	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	1158903	1789016	57339967	74	8515										
MUC16	94025	broad.mit.edu	37	chr19	9018160	9018160	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aggtcagtctgcagccagagTacagaaggccaacactggtg	13	10	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:9018160T>C	uc002mkp.2	-	25	37982	c.37778A>G	c.(37777-37779)TAC>TGC	p.Y12593C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12595	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCAGCCAGAGTACAGAAGGCC	0.537													0	0	0	0.013726	0	29	99										C	9018160	T	C	9018160	3	2	33	1	0	0	0	0	1	0	0	0	9973	1638	57	5	5985	5	MUC16	19	9018160	Missense_Mutation	SNP	T	TCGA-CF-A3MI-01A-11D-A20D-08	7229144	9018160	50110823	75	8516										
TSSK6	83983	broad.mit.edu	37	chr19	19626255	19626255	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	atggtggcgcctagggcgcaCggggggcaggaggcggctgc	22	10	0	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:19626255C>T	uc002nmr.2	-	1	215	c.-18G>A	c.(-20--16)CCGTG>CCATG		TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6						multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						CTAGGGCGCACGGGGGGCAGG	0.652													0	0	0	0.008291	0	9	21										T	19626255	C	T	19626255	1	4	33	1	0	0	0	0	0	0	0	0	16669	551	19	2		2	TSSK6	19	19626255	Translation_Start_Site	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	10608095	19626255	39502728	76	8517										
ZNF677	342926	broad.mit.edu	37	chr19	53740952	53740952	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	tacatttgtaaggtttctctCcagtatgcatcctctgatga	7	9	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr19:53740952C>G	uc002qbf.1	-	5	1213	c.1028G>C	c.(1027-1029)GGA>GCA	p.G343A	ZNF677_uc002qbg.1_Missense_Mutation_p.G343A	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		AGGTTTCTCTCCAGTATGCAT	0.388													0	0	0	0.001984	0	6	41										G	53740952	C	G	53740952	3	3	33	1	0	0	0	0	1	0	0	0	18081	855	30	1	730	1	ZNF677	19	53740952	Missense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	34114697	53740952	5388031	77	8518										
TGM6	343641	broad.mit.edu	37	chr20	2413265	2413265	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gacatcaagggctttgtgatCgtccatgtggccactgccaa	11	11	1	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr20:2413265C>T	uc002wfy.1	+	13	2158	c.2097C>T	c.(2095-2097)ATC>ATT	p.I699I	TGM6_uc010gal.1_3'UTR	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	699					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GCTTTGTGATCGTCCATGTGG	0.552													0	0	0	0.00499	0	16	95										T	2413265	C	T	2413265	2	4	33	1	0	0	0	0	0	0	0	1	15831	874	31	1		1	TGM6	20	2413265	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		2413265	60612255	78	8519										
CTCFL	140690	broad.mit.edu	37	chr20	56093885	56093885	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	atgtttatagcgcctgtgtcGgacgagttctccactggtga	12	9	1	1			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr20:56093885G>A	uc010gix.1	-	4	1650	c.988C>T	c.(988-990)CGA>TGA	p.R330*	CTCFL_uc010giw.1_Nonsense_Mutation_p.R330*|CTCFL_uc002xym.2_Nonsense_Mutation_p.R330*|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjb.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjc.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjd.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gje.2_Nonsense_Mutation_p.R330*|CTCFL_uc010gjf.2_Nonsense_Mutation_p.R125*|CTCFL_uc010gjg.2_Nonsense_Mutation_p.R62*|CTCFL_uc010gjh.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gji.1_Nonsense_Mutation_p.R125*|CTCFL_uc010gjj.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjk.1_Nonsense_Mutation_p.R330*|CTCFL_uc010gjl.1_Nonsense_Mutation_p.R330*	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	330	C2H2-type 3.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CGCCTGTGTCGGACGAGTTCT	0.433													0	0	0	0.00308	0	7	96										A	56093885	G	A	56093885	4	1	33	1	0	0	0	0	0	1	0	0	4001	1124	39	2	1031	2	CTCFL	20	56093885	Nonsense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08	53680620	56093885	6931635	79	8520										
SYNJ1	8867	broad.mit.edu	37	chr21	34011221	34011221	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	taacaaatgagacttacttgCggttgtgaggaagcttctga	11	6	1	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr21:34011221C>T	uc002yqh.2	-	31	4029	c.4029G>A	c.(4027-4029)CCG>CCA	p.P1343P	SYNJ1_uc011ads.1_Silent_p.P1257P|SYNJ1_uc002yqf.2_Silent_p.P1288P|SYNJ1_uc002yqg.2_Silent_p.P1257P|SYNJ1_uc002yqi.2_Silent_p.P1343P|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1304	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding	p.P1304P(1)		ovary(4)|skin(1)	5						GACTTACTTGCGGTTGTGAGG	0.408													0	0	0	0.00308	0	4	147										T	34011221	C	T	34011221	2	4	33	1	0	0	0	0	0	0	0	1	15449	755	27	2		2	SYNJ1	21	34011221	Silent	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08		34011221	14118674	80	8521										
TCF20	6942	broad.mit.edu	37	chr22	42610592	42610592	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aaggaggaggaggaggaggaGgaagcagaagactgatagtg	20	2	0	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chr22:42610592G>A	uc003bcj.1	-	1	854	c.720C>T	c.(718-720)TCC>TCT	p.S240S	TCF20_uc003bck.1_Silent_p.S240S|TCF20_uc003bnt.2_Silent_p.S240S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	240	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						aggaggaggaggaAGCAGAAG	0.443													0	0	0	0.004672	0	3	45										A	42610592	G	A	42610592	2	1	33	1	0	0	0	0	0	0	0	1	15687	987	35	2		2	TCF20	22	42610592	Silent	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		42610592	8693974	81	8522										
CXCR3	2833	broad.mit.edu	37	chrX	70836460	70836460	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gctttctcggccacagttgcGggccaaagcgcccaggtcca	12	15	1	0			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:70836460G>A	uc004eaf.2	-	2	930	c.862C>T	c.(862-864)CGC>TGC	p.R288C	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Missense_Mutation_p.R335C	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	288	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					CCACAGTTGCGGGCCAAAGCG	0.632													0	0	0	0.006122	0	16	16										A	70836460	G	A	70836460	3	1	33	1	0	0	0	0	1	0	0	0	4092	1116	39	2	248	2	CXCR3	23	70836460	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		70836460	84434100	82	8523										
STAG2	10735	broad.mit.edu	37	chrX	123217380	123217380	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	aattttcttctaaactacttCgacaagacaaaagaacagtg	5	8	2	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:123217380C>T	uc004etz.3	+	28	3373	c.3034C>T	c.(3034-3036)CGA>TGA	p.R1012*	STAG2_uc004eua.2_Nonsense_Mutation_p.R1012*|STAG2_uc004eub.2_Nonsense_Mutation_p.R1012*|STAG2_uc004euc.2_Nonsense_Mutation_p.R1012*|STAG2_uc004eud.2_Nonsense_Mutation_p.R1012*|STAG2_uc004eue.2_Nonsense_Mutation_p.R1012*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1012					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TAAACTACTTCGACAAGACAA	0.343													0	0	0	0.01441	0	34	0										T	123217380	C	T	123217380	4	4	33	1	0	0	0	0	0	1	0	0	15242	876	31	1	3140	1	STAG2	23	123217380	Nonsense_Mutation	SNP	C	TCGA-CF-A3MI-01A-11D-A20D-08	52380920	123217380	32053180	83	8524										
GPC3	2719	broad.mit.edu	37	chrX	132670204	132670204	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	agatggccatgctggtgagaAgcttcagcggggaatgaacg	16	7	1	3			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrX:132670204A>C	uc004exe.1	-	8	1881	c.1691T>G	c.(1690-1692)CTT>CGT	p.L564R	GPC3_uc004exd.1_Missense_Mutation_p.L436R|GPC3_uc010nrn.1_Missense_Mutation_p.L587R|GPC3_uc011mvh.1_Missense_Mutation_p.L548R|GPC3_uc010nro.1_Missense_Mutation_p.L510R	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	564						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCTGGTGAGAAGCTTCAGCGG	0.562			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				0	0	0	0.01441	0	57	3										C	132670204	A	C	132670204	3	2	33	1	0	0	0	0	1	0	0	0	6599	72	3	5	55	5	GPC3	23	132670204	Missense_Mutation	SNP	A	TCGA-CF-A3MI-01A-11D-A20D-08	9452824	132670204	22600356	84	8525										
TBL1Y	90665	broad.mit.edu	37	chrY	6911149	6911149	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.273809523809524	23	3.30698692813287e-06	2.83666666666667	4.78823529411765	2.06511627906977	1	1	15	gactgcagtatgtagaggctGagataagcatcaacaaggta	12	6	1	2			TCGA-CF-A3MI-01A-11D-A20D-08	TCGA-CF-A3MI-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0afabd62-8454-41b4-9b02-386681589688	0213b9a1-5fdd-4064-aaf8-79fbc9715fff	g.chrY:6911149G>C	uc004frb.2	+	7	834	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	TBL1Y_uc004frc.2_Missense_Mutation_p.E63Q|TBL1Y_uc004frd.2_Missense_Mutation_p.E63Q|TBL1Y_uc011nap.1_5'UTR	NM_033284	NP_150600	Q9BQ87	TBL1Y_HUMAN	transducin beta-like 1Y	63	F-box-like.				transcription, DNA-dependent						0						TGTAGAGGCTGAGATAAGCAT	0.527													0	0	0	0.010729	0	10	62										C	6911149	G	C	6911149	3	2	33	1	0	0	0	0	1	0	0	0	15638	1291	45	1	193	1	TBL1Y	24	6911149	Missense_Mutation	SNP	G	TCGA-CF-A3MI-01A-11D-A20D-08		6911149	52462417	85	8526										
TNFRSF1B	7133	broad.mit.edu	37	chr1	12253005	12253005	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cccggagtatggccccagggGcagtacacttaccccagcca	11	16	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:12253005G>C	uc001att.2	+	6	726	c.637G>C	c.(637-639)GCA>CCA	p.A213P	TNFRSF1B_uc001atu.2_Missense_Mutation_p.A18P|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	213	Extracellular (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GGCCCCAGGGGCAGTACACTT	0.617													0	0	0	0.069288	0	19	54										C	12253005	G	C	12253005	3	2	34	1	0	0	0	0	1	0	0	0	16291	1203	42	4	659	4	TNFRSF1B	1	12253005	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		12253005	236997616	1	8527										
ACTL8	81569	broad.mit.edu	37	chr1	18152501	18152501	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaggaagattgcgatagacgCtgcctgtttcagctggagac	13	8	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:18152501C>G	uc001bat.2	+	3	804	c.588C>G	c.(586-588)CGC>CGG	p.R196R		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	196						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GCGATAGACGCTGCCTGTTTC	0.597											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.080935	0	11	63										G	18152501	C	G	18152501	2	3	34	1	0	0	0	0	0	0	0	1	202	784	28	4		4	ACTL8	1	18152501	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	5899496	18152501	231098120	2	8528										
RIMS3	9783	broad.mit.edu	37	chr1	41101634	41101634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gctcccatcggtggactcccGgctgccctggcgtgtgaccc	13	17	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:41101634G>A	uc001cfu.1	-	4	782	c.313C>T	c.(313-315)CGG>TGG	p.R105W	RIMS3_uc001cfv.1_Missense_Mutation_p.R105W	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	105					neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			GTGGACTCCCGGCTGCCCTGG	0.682													0	0	0	0.038147	0	7	91										A	41101634	G	A	41101634	3	1	34	1	0	0	0	0	1	0	0	0	13369	1115	39	2	633	2	RIMS3	1	41101634	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	22949133	41101634	208148987	3	8529										
ELAVL4	1996	broad.mit.edu	37	chr1	50666658	50666658	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agtgtcctctggcagctcttTggcccctttggagcagtgaa	12	11	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:50666658T>C	uc001csb.2	+	7	1219	c.951T>C	c.(949-951)TTT>TTC	p.F317F	ELAVL4_uc001cry.3_Silent_p.F306F|ELAVL4_uc001crz.3_Silent_p.F303F|ELAVL4_uc001csa.3_Silent_p.F320F|ELAVL4_uc001csc.3_Silent_p.F303F|ELAVL4_uc010omz.1_Silent_p.F308F	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	317	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GGCAGCTCTTTGGCCCCTTTG	0.507													0	0	0	0.050027	0	34	123										C	50666658	T	C	50666658	2	2	34	1	0	0	0	0	0	0	0	1	5052	1809	63	5		5	ELAVL4	1	50666658	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	9565024	50666658	198583963	4	8530										
LHX8	431707	broad.mit.edu	37	chr1	75622760	75622760	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcgctgcatagttatatggaTggtaggtatcccaacattta	10	7	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:75622760T>A	uc001dgo.2	+	9	1657	c.993T>A	c.(991-993)GAT>GAA	p.D331E	LHX8_uc001dgq.2_Missense_Mutation_p.D270E	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	331						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GTTATATGGATGGTAGGTATC	0.418													0	0	0	0.048971	0	57	58										A	75622760	T	A	75622760	3	1	34	1	0	0	0	0	1	0	0	0	8776	1478	51	5	1023	5	LHX8	1	75622760	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	24956102	75622760	173627861	5	8531										
HFM1	164045	broad.mit.edu	37	chr1	91739336	91739336	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tcaggctgatcccactgctcCattataggcaattcagatat	7	11	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:91739336C>A	uc001doa.3	-	34	3805	c.3705G>T	c.(3703-3705)ATG>ATT	p.M1235I	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.M914I|HFM1_uc001dob.3_Missense_Mutation_p.M423I|HFM1_uc010osv.1_Missense_Mutation_p.M919I	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1235							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CCCACTGCTCCATTATAGGCA	0.308													1	0	2.31682e-05	0.024245	2.39517e-05	14	164										A	91739336	C	A	91739336	3	1	34	1	0	0	0	0	1	0	0	0	7083	594	21	4	626	4	HFM1	1	91739336	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	16116576	91739336	157511285	6	8532										
LPPR4	9890	broad.mit.edu	37	chr1	99772549	99772549	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acaaaggaacctcccccacaCgggcttataaggattgagtg	10	11	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:99772549C>A	uc001dse.2	+	7	2381	c.2275C>A	c.(2275-2277)CGG>AGG	p.R759R	LPPR4_uc010oue.1_Silent_p.R701R	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	759							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CTCCCCCACACGGGCTTATAA	0.458													1	0	3.82636e-28	0.048971	4.42617e-28	83	111										A	99772549	C	A	99772549	2	1	34	1	0	0	0	0	0	0	0	1	8927	527	19	4		4	LPPR4	1	99772549	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	8033213	99772549	149478072	7	8533										
S1PR1	1901	broad.mit.edu	37	chr1	101704696	101704697	+	Missense_Mutation	DNP	CA	CA	AT													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaactgacctcggtggtgttCattctcatctgctgctttat							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:101704696_101704697CA>AT	uc001dud.2	+	2	670_671	c.156_157CA>AT	c.(154-159)TTCATT>TTATTT	p.52_53FI>LF	S1PR1_uc009weg.2_Missense_Mutation_p.52_53FI>LF	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	52_53	Helical; Name=1; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						CGGTGGTGTTCATTCTCATCTG	0.436											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	55	107										AT	101704697	CA	AT	101704696	3	1	34	1	0	0	0	0	1	0	0	0	13793	825	29	3	158	3	S1PR1	1	101704696	Missense_Mutation	DNP	CA	TCGA-CU-A0YN-01A-21D-A10S-08	1932147	101704696	147545925	8	8534										
GPR61	83873	broad.mit.edu	37	chr1	110085756	110085756	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tcccggaggtggggctacggGatgttgcttcggaatctgtg	17	8	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:110085756G>T	uc001dxy.2	+	2	795	c.112G>T	c.(112-114)GAT>TAT	p.D38Y		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	38	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGGGCTACGGGATGTTGCTTC	0.612													1	0	1.39806e-14	0.037714	1.52645e-14	32	206										T	110085756	G	T	110085756	3	4	34	1	0	0	0	0	1	0	0	0	6702	1174	41	3	114	3	GPR61	1	110085756	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	8381060	110085756	139164865	9	8535										
BGLAP	632	broad.mit.edu	37	chr1	156212941	156212941	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gaggcctatcggcgcttctaCggcccggtctagggtgtcgc	15	13	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:156212941C>A	uc001fnt.2	+	4	363	c.291C>A	c.(289-291)TAC>TAA	p.Y97*	BGLAP_uc001fns.1_3'UTR	NM_199173	NP_954642	P02818	OSTCN_HUMAN	osteocalcin preproprotein	97	Gla.				bone mineralization|cell adhesion|odontogenesis|regulation of bone mineralization|regulation of bone resorption|regulation of osteoclast differentiation		calcium ion binding|hydroxyapatite binding|structural constituent of bone				0	Hepatocellular(266;0.158)				Phytonadione(DB01022)	GGCGCTTCTACGGCCCGGTCT	0.637													1	0	8.72198e-27	0.048971	1.0035e-26	48	143										A	156212941	C	A	156212941	4	1	34	1	0	0	0	0	0	1	0	0	1417	547	19	4	305	4	BGLAP	1	156212941	Nonsense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	46127185	156212941	93037680	10	8536										
SPTA1	6708	broad.mit.edu	37	chr1	158631163	158631163	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tctccaggatgactctatgcCtattcagaagctttttggaa	8	9	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:158631163C>T	uc001fst.1	-	18	2700	c.2501G>A	c.(2500-2502)AGG>AAG	p.R834K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	834	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GACTCTATGCCTATTCAGAAG	0.423													0	0	0	0.074837	0	36	140										T	158631163	C	T	158631163	3	4	34	1	0	0	0	0	1	0	0	0	15115	681	24	2	4898	2	SPTA1	1	158631163	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	2418222	158631163	90619458	11	8537										
OR6K2	81448	broad.mit.edu	37	chr1	158670235	158670236	+	Nonsense_Mutation	DNP	CC	CC	AG													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggctgtggtataccaaatctCcaggaaagaaagagcactga							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:158670235_158670236CC>AG	uc001fsu.1	-	1	207_208	c.207_208GG>CT	c.(205-210)CTGGAG>CTCTAG	p.E70*		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TACCAAATCTCCAGGAAAGAAA	0.436													0	0	0	0.004672	0	11	62										AG	158670236	CC	AG	158670235	4	1	34	1	0	0	0	0	0	1	0	0	11202	864	30	3	770	3	OR6K2	1	158670235	Nonsense_Mutation	DNP	CC	TCGA-CU-A0YN-01A-21D-A10S-08	39072	158670235	90580386	12	8538										
OR6N1	128372	broad.mit.edu	37	chr1	158736303	158736303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgacaaagtggtacatgggtGtgtgaagccgggagtccagg	17	6	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:158736303G>A	uc010piq.1	-	1	170	c.170C>T	c.(169-171)ACA>ATA	p.T57I		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GTACATGGGTGTGTGAAGCCG	0.483													0	0	0	0.034045	0	29	98										A	158736303	G	A	158736303	3	1	34	1	0	0	0	0	1	0	0	0	11206	1377	48	2	771	2	OR6N1	1	158736303	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	66068	158736303	90514318	13	8539										
MR1	3140	broad.mit.edu	37	chr1	181018369	181018369	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcgcctgatcactgggagagGtacactcagctgctgagggg	16	10	2	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:181018369G>A	uc001goq.1	+	2	254	c.249G>A	c.(247-249)AGG>AGA	p.R83R	MR1_uc001gop.2_Silent_p.R83R|MR1_uc001gor.1_Silent_p.R83R|MR1_uc001gos.1_Silent_p.R83R|MR1_uc010pns.1_Silent_p.R83R	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	83	Extracellular (Potential).|Ligand-binding.|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						ACTGGGAGAGGTACACTCAGC	0.582													0	0	0	0.105934	0	14	47										A	181018369	G	A	181018369	2	1	34	1	0	0	0	0	0	0	0	1	9752	1252	44	2		2	MR1	1	181018369	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	22282066	181018369	68232252	14	8540										
CACNA1E	777	broad.mit.edu	37	chr1	181725138	181725138	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acaagatggaggtgaagggcCgggaatggaagcgccatgaa	17	6	0	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:181725138C>T	uc001gow.2	+	29	4201	c.4036C>T	c.(4036-4038)CGG>TGG	p.R1346W	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1234W|CACNA1E_uc001gox.1_Missense_Mutation_p.R572W|CACNA1E_uc009wxt.2_Missense_Mutation_p.R572W	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1346	Extracellular (Potential).|III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GGTGAAGGGCCGGGAATGGAA	0.493													0	0	0	0.09319	0	11	51										T	181725138	C	T	181725138	3	4	34	1	0	0	0	0	1	0	0	0	2542	643	23	2	4150	2	CACNA1E	1	181725138	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	706769	181725138	67525483	15	8541										
TROVE2	6738	broad.mit.edu	37	chr1	193038543	193038543	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agctgtttctgaagtttgtcGcattcctacccatctcttta	6	11	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:193038543G>A	uc001gss.2	+	2	534	c.359G>A	c.(358-360)CGC>CAC	p.R120H	TROVE2_uc001gst.1_Intron|TROVE2_uc001gsu.1_Intron|TROVE2_uc001gsv.1_Missense_Mutation_p.R120H|TROVE2_uc001gsw.2_Missense_Mutation_p.R120H|TROVE2_uc009wyp.2_Missense_Mutation_p.R120H|TROVE2_uc009wyq.2_Missense_Mutation_p.R120H|TROVE2_uc001gsx.1_Missense_Mutation_p.R120H	NM_004600	NP_004591	P10155	RO60_HUMAN	TROVE domain family, member 2 isoform 2	120	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0						GAAGTTTGTCGCATTCCTACC	0.448													0	0	0	0.099896	0	26	66										A	193038543	G	A	193038543	3	1	34	1	0	0	0	0	1	0	0	0	16573	1087	38	2	361	2	TROVE2	1	193038543	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	11313405	193038543	56212078	16	8542										
CFH	3075	broad.mit.edu	37	chr1	196658607	196658607	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tctatatcatgagaatatgcGtagaccatactttccagtag	7	8	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:196658607G>A	uc001gtj.3	+	8	1262	c.1022G>A	c.(1021-1023)CGT>CAT	p.R341H	CFH_uc001gti.3_Missense_Mutation_p.R341H|CFH_uc009wyw.2_Intron|CFH_uc009wyx.2_Missense_Mutation_p.R277H	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	341	Sushi 6.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GAGAATATGCGTAGACCATAC	0.323													0	0	0	0.062417	0	20	86										A	196658607	G	A	196658607	3	1	34	1	0	0	0	0	1	0	0	0	3283	1145	40	2	1052	2	CFH	1	196658607	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	3620064	196658607	52592014	17	8543										
MFSD4	148808	broad.mit.edu	37	chr1	205538365	205538365	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctgccccagatctcctgggtCttcttctcgcagcagctctg	9	16	5	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr1:205538365C>T	uc001hcv.3	+	1	254	c.168C>T	c.(166-168)GTC>GTT	p.V56V	MFSD4_uc010prk.1_Silent_p.V56V|MFSD4_uc010prl.1_RNA	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	56	Helical; (Potential).				transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TCTCCTGGGTCTTCTTCTCGC	0.602													0	0	0	0.038147	0	6	14										T	205538365	C	T	205538365	2	4	34	1	0	0	0	0	0	0	0	1	9533	900	32	1		1	MFSD4	1	205538365	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	8879758	205538365	43712256	18	8544										
RPS7	6201	broad.mit.edu	37	chr2	3627748	3627748	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atccttgaggacttggtcttCccaagcgaaattgtgggcaa	11	9	1	1	rs149082052		TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:3627748C>T	uc002qxw.2	+	6	511	c.405C>T	c.(403-405)TTC>TTT	p.F135F	RPS7_uc002qxy.2_RNA	NM_001011	NP_001002	P62081	RS7_HUMAN	ribosomal protein S7	135					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		ACTTGGTCTTCCCAAGCGAAA	0.493													0	0	0	0.048971	0	67	94										T	3627748	C	T	3627748	2	4	34	1	0	0	0	0	0	0	0	1	13660	854	30	1		1	RPS7	2	3627748	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08		3627748	239571625	19	8545										
GTF3C2	2976	broad.mit.edu	37	chr2	27551030	27551030	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccttcaggactgtcctgataCggtatcagatctgctttata	8	10	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:27551030C>T	uc002rjv.1	-	18	2646	c.2283G>A	c.(2281-2283)CCG>CCA	p.P761P	MPV17_uc002rjt.2_5'Flank|GTF3C2_uc010eyy.1_Silent_p.P216P|GTF3C2_uc002rju.1_Silent_p.P772P|GTF3C2_uc002rjw.1_Silent_p.P761P	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	761						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTCCTGATACGGTATCAGAT	0.443													0	0	0	0.054565	0	28	53										T	27551030	C	T	27551030	2	4	34	1	0	0	0	0	0	0	0	1	6873	523	19	2		2	GTF3C2	2	27551030	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	23923282	27551030	215648343	20	8546										
C2orf40	84417	broad.mit.edu	37	chr2	106694282	106694282	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaatggacatgaatactatgGcgattactaccaacgtcact	7	9	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:106694282G>A	uc010fjf.2	+	4	455	c.347G>A	c.(346-348)GGC>GAC	p.G116D		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	116						extracellular region|transport vesicle					0						GAATACTATGGCGATTACTAC	0.433													0	0	0	0.09836	0	40	64										A	106694282	G	A	106694282	3	1	34	1	0	0	0	0	1	0	0	0	2165	1203	42	2	361	2	C2orf40	2	106694282	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	79143252	106694282	136505091	21	8547										
CXCR4	7852	broad.mit.edu	37	chr2	136872564	136872564	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggtgagtgcgtgctgggcagAggttttaaatttggctccaa	15	6	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:136872564A>C	uc002tuz.2	-	2	1029	c.934T>G	c.(934-936)TCT>GCT	p.S312A	CXCR4_uc002tuy.2_Missense_Mutation_p.S316A|CXCR4_uc010fnk.2_Missense_Mutation_p.S297A	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	312	Cytoplasmic.				activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	TGCTGGGCAGAGGTTTTAAAT	0.512													0	0	0	0.048971	0	340	531										C	136872564	A	C	136872564	3	2	34	1	0	0	0	0	1	0	0	0	4093	304	11	5	128	5	CXCR4	2	136872564	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	30178282	136872564	106326809	22	8548										
THSD7B	80731	broad.mit.edu	37	chr2	138414424	138414424	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgtgaattaacctgcattgaTggaagaagctttgagactgt	11	5	0	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:138414424T>C	uc002tva.1	+	22	4077	c.4077T>C	c.(4075-4077)GAT>GAC	p.D1359D	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGCATTGATGGAAGAAGCT	0.453													0	0	0	0.069288	0	24	38										C	138414424	T	C	138414424	2	2	34	1	0	0	0	0	0	0	0	1	15877	1461	51	5		5	THSD7B	2	138414424	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	1541860	138414424	104784949	23	8549										
LRP1B	53353	broad.mit.edu	37	chr2	141283905	141283905	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgcacagcggaactcaaccgTggcacaggttgaaactagaa	11	10	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:141283905T>C	uc002tvj.1	-	48	8749	c.7777A>G	c.(7777-7779)ACG>GCG	p.T2593A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2593	Extracellular (Potential).|LDL-receptor class A 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AACTCAACCGTGGCACAGGTT	0.388										TSP Lung(27;0.18)			0	0	0	0.037714	0	29	42										C	141283905	T	C	141283905	3	2	34	1	0	0	0	0	1	0	0	0	8955	1696	59	5	6198	5	LRP1B	2	141283905	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	2869481	141283905	101915468	24	8550										
TTN	7273	broad.mit.edu	37	chr2	179472164	179472164	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggctgctgcaaatttggaacCacagctatttgtagctgtaa	10	8	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:179472164C>T	uc010zfg.1	-	226	45771	c.45547G>A	c.(45547-45549)GGT>AGT	p.G15183S	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G8878S|TTN_uc010zfi.1_Missense_Mutation_p.G8811S|TTN_uc010zfj.1_Missense_Mutation_p.G8686S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16110							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTTGGAACCACAGCTATTT	0.378													0	0	0	0.048971	0	81	129										T	179472164	C	T	179472164	3	4	34	1	0	0	0	0	1	0	0	0	16732	594	21	2	54786	2	TTN	2	179472164	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	38188259	179472164	63727209	25	8551										
TTN	7273	broad.mit.edu	37	chr2	179583684	179583684	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tccacagaatcaggggtttgTtcaaaagatggtggttctag	12	6	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:179583684T>A	uc010zfg.1	-	81	20735	c.20511A>T	c.(20509-20511)GAA>GAT	p.E6837D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E3498D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7764							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGGGTTTGTTCAAAAGATG	0.448													0	0	0	0.080935	0	10	11										A	179583684	T	A	179583684	3	1	34	1	0	0	0	0	1	0	0	0	16732	1722	60	5	80402	5	TTN	2	179583684	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	111520	179583684	63615689	26	8552										
ABCA12	26154	broad.mit.edu	37	chr2	215854127	215854127	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctaggattagacagcacagcCagccaaatgaggtggtgtca	12	9	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr2:215854127C>T	uc002vew.2	-	26	3975	c.3755G>A	c.(3754-3756)TGG>TAG	p.W1252*	ABCA12_uc002vev.2_Nonsense_Mutation_p.W934*|ABCA12_uc010zjn.1_Nonsense_Mutation_p.W179*	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1252	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACAGCACAGCCAGCCAAATGA	0.428													0	0	0	0.092188	0	39	65										T	215854127	C	T	215854127	4	4	34	1	0	0	0	0	0	1	0	0	30	595	21	2	4144	2	ABCA12	2	215854127	Nonsense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	36270443	215854127	27345246	27	8553										
CCBP2	1238	broad.mit.edu	37	chr3	42906025	42906025	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctgcctctccgcagccactcGccactgaggatgccgattct	9	17	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:42906025G>A	uc003cme.2	+	3	210	c.31G>A	c.(31-33)GCC>ACC	p.A11T	CCBP2_uc003cmd.1_Missense_Mutation_p.A11T|CCBP2_uc003cmf.2_Missense_Mutation_p.A11T|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	11	Extracellular (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		GCAGCCACTCGCCACTGAGGA	0.542													0	0	0	0.050027	0	30	41										A	42906025	G	A	42906025	3	1	34	1	0	0	0	0	1	0	0	0	2734	1087	38	2	33	2	CCBP2	3	42906025	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		42906025	155116405	28	8554										
SCAP	22937	broad.mit.edu	37	chr3	47461048	47461048	+	Frame_Shift_Del	DEL	G	G	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaggcagggtccgggtggctGgggggcagcatgccactagg							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:47461048delG	uc003crh.1	-	13	1965	c.1710delC	c.(1708-1710)CCCfs	p.P570fs	SCAP_uc011baz.1_Frame_Shift_Del_p.P315fs|SCAP_uc003crg.2_Frame_Shift_Del_p.P178fs	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	570	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		CCGGGTGGCTGGGGGGCAGCA	0.657																		11	92	---	---								-	47461048	G	-	47461048	7	5	34	1	0	1	0	1	0	0	0	0	13877	1335	47	0	2173	0	SCAP	3	47461048	Frame_Shift_Del	DEL	G	TCGA-CU-A0YN-01A-21D-A10S-08	4555023	47461048	150561382	29	8555										
RASSF1	11186	broad.mit.edu	37	chr3	50369047	50369047	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cttgcgggggtcatccaccaCcaagaactttcgcagcaggg	12	13	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:50369047C>T	uc003dad.1	-	4	846	c.715G>A	c.(715-717)GTG>ATG	p.V239M	RASSF1_uc003daa.1_Missense_Mutation_p.V84M|RASSF1_uc003dab.1_Missense_Mutation_p.V165M|RASSF1_uc003dac.2_Missense_Mutation_p.V84M|RASSF1_uc003dae.1_Missense_Mutation_p.V235M|RASSF1_uc010hlk.1_RNA|RASSF1_uc003daf.1_Missense_Mutation_p.V84M	NM_170714	NP_733832	Q9NS23	RASF1_HUMAN	Ras association domain family 1 isoform D	239	Ras-associating.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCATCCACCACCAAGAACTTT	0.577													0	0	0	0.028581	0	16	114										T	50369047	C	T	50369047	3	4	34	1	0	0	0	0	1	0	0	0	13084	507	18	2	331	2	RASSF1	3	50369047	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	2907999	50369047	147653383	30	8556										
WDR52	55779	broad.mit.edu	37	chr3	113145001	113145001	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gaagatccagtggtatgtttGaatccagagtcacaaaaggc	11	7	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:113145001G>C	uc003eae.1	-	4	423	c.377C>G	c.(376-378)TCA>TGA	p.S126*		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	126										central_nervous_system(1)	1						TGGTATGTTTGAATCCAGAGT	0.353													0	0	0	0.048971	0	122	219										C	113145001	G	C	113145001	4	2	34	1	0	0	0	0	0	1	0	0	17301	1294	45	1	5330	1	WDR52	3	113145001	Nonsense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	62775954	113145001	84877429	31	8557										
ARGFX	503582	broad.mit.edu	37	chr3	121305213	121305213	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gaactgtacaatcttcctgaTgagaatgagatatccagctc	8	9	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:121305213T>A	uc003eef.2	+	5	809	c.714T>A	c.(712-714)GAT>GAA	p.D238E		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	238						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		ATCTTCCTGATGAGAATGAGA	0.463													0	0	0	0.048971	0	63	112										A	121305213	T	A	121305213	3	1	34	1	0	0	0	0	1	0	0	0	859	1461	51	5	728	5	ARGFX	3	121305213	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	8160212	121305213	76717217	32	8558										
FBXO40	51725	broad.mit.edu	37	chr3	121345737	121345737	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccacctttagaatcagaccaCgaggaagatacgtctcctaa	7	12	2	3	rs139292085		TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:121345737C>T	uc003eeg.2	+	4	2320	c.2110C>T	c.(2110-2112)CGA>TGA	p.R704*		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	704					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		AATCAGACCACGAGGAAGATA	0.483													0	0	0	0.050027	0	31	62										T	121345737	C	T	121345737	4	4	34	1	0	0	0	0	0	1	0	0	5749	528	19	2	2120	2	FBXO40	3	121345737	Nonsense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	40524	121345737	76676693	33	8559										
H1FX	8971	broad.mit.edu	37	chr3	129034521	129034521	+	Missense_Mutation	SNP	C	C	G													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tggtcgaaccacggaaccttCttggcctcggtgtagatctt							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:129034521C>G	uc003elx.2	-	1	600	c.225G>C	c.(223-225)AAG>AAC	p.K75N	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	75	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding				0						ACGGAACCTTCTTGGCCTCGG	0.617													0	0	0	0.047766	0	9	5										G	129034521	C	G	129034521	3	3	34	1	0	0	0	0	1	0	0	0	6923	912	32	1	420	1	H1FX	3	129034521	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	7688784	129034521	68987909	34	8560	41	2								
H1FX	8971	broad.mit.edu	37	chr3	129034529	129034529	+	Missense_Mutation	SNP	C	C	T													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccacggaaccttcttggcctCggtgtagatcttggccagcg							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:129034529C>T	uc003elx.2	-	1	592	c.217G>A	c.(217-219)GAG>AAG	p.E73K	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	73	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTCTTGGCCTCGGTGTAGATC	0.597													0	0	0	0.038147	0	7	5										T	129034529	C	T	129034529	3	4	34	1	0	0	0	0	1	0	0	0	6923	893	31	1	428	1	H1FX	3	129034529	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	8	129034529	68987901	35	8561	41	2								
PRR23B	389151	broad.mit.edu	37	chr3	138738777	138738777	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cggcgagcgcgcgtggggacCtggactccccacgcacggag	17	15	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:138738777C>T	uc003esy.1	-	1	992	c.727G>A	c.(727-729)GGT>AGT	p.G243S		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	243	Pro-rich.									breast(1)	1						GCGTGGGGACCTGGACTCCCC	0.652													0	0	0	0.047766	0	7	33										T	138738777	C	T	138738777	3	4	34	1	0	0	0	0	1	0	0	0	12595	681	24	2	74	2	PRR23B	3	138738777	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	9704248	138738777	59283653	36	8562										
GPR171	29909	broad.mit.edu	37	chr3	150916249	150916249	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acatcttaatttttctttctGagccttggtctctttaggtg	7	8	4	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr3:150916249G>A	uc003eyq.3	-	3	1165	c.925C>T	c.(925-927)CAG>TAG	p.Q309*	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_013308	NP_037440	O14626	GP171_HUMAN	G protein-coupled receptor 171	309	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTTCTTTCTGAGCCTTGGTC	0.388													0	0	0	0.080422	0	39	75										A	150916249	G	A	150916249	4	1	34	1	0	0	0	0	0	1	0	0	6668	1299	45	1	38	1	GPR171	3	150916249	Nonsense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	12177472	150916249	47106181	37	8563										
FAM193A	8603	broad.mit.edu	37	chr4	2701490	2701490	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gagcagaggcggcgggaggaGgaggaggatgaggaagaaga	23	3	0	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:2701490G>T	uc010icl.2	+	17	3069	c.2718G>T	c.(2716-2718)GAG>GAT	p.E906D	FAM193A_uc010ick.2_Missense_Mutation_p.E1106D|FAM193A_uc003gfd.2_Missense_Mutation_p.E906D|FAM193A_uc011bvm.1_Missense_Mutation_p.E928D|FAM193A_uc011bvn.1_Missense_Mutation_p.E906D|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.E760D	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	906	Glu-rich.|Potential.									ovary(3)	3						GGCGggaggaggaggaggatg	0.458													1	0	0.00448238	0.047766	0.00454611	8	39										T	2701490	G	T	2701490	3	4	34	1	0	0	0	0	1	0	0	0	5524	991	35	4	2776	4	FAM193A	4	2701490	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		2701490	188452786	38	8564										
EVC2	132884	broad.mit.edu	37	chr4	5564598	5564598	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtccatgcccaaggccctcaTggcctttttggcattcaaaa	8	13	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:5564598T>A	uc003gij.2	-	22	3958	c.3904A>T	c.(3904-3906)ATG>TTG	p.M1302L	EVC2_uc011bwb.1_Missense_Mutation_p.M742L|EVC2_uc003gik.2_Missense_Mutation_p.M1222L	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1302						integral to membrane				large_intestine(3)|ovary(2)	5						AAGGCCCTCATGGCCTTTTTG	0.488													0	0	0	0.048971	0	51	112										A	5564598	T	A	5564598	3	1	34	1	0	0	0	0	1	0	0	0	5286	1464	51	5	26	5	EVC2	4	5564598	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	2863108	5564598	185589678	39	8565										
LAP3	51056	broad.mit.edu	37	chr4	17606232	17606232	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgccatggatgtagctttggGatcaggtgccactggggtct	15	8	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:17606232G>T	uc003gph.1	+	11	1364	c.1202G>T	c.(1201-1203)GGA>GTA	p.G401V		NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	401					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						GTAGCTTTGGGATCAGGTGCC	0.478													1	0	7.03913e-09	0.09319	7.42056e-09	11	114										T	17606232	G	T	17606232	3	4	34	1	0	0	0	0	1	0	0	0	8623	1174	41	3	1244	3	LAP3	4	17606232	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	12041634	17606232	173548044	40	8566										
GBA3	57733	broad.mit.edu	37	chr4	22749341	22749341	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaccagcagatcccaactcaGtgtctgaccaggaagctgct	9	13	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:22749341G>C	uc003gqp.3	+	3	800	c.709G>C	c.(709-711)GTG>CTG	p.V237L	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.V238L	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	237					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						TCCCAACTCAGTGTCTGACCA	0.428													0	0	0	0.104719	0	36	177										C	22749341	G	C	22749341	3	2	34	1	0	0	0	0	1	0	0	0	6268	1029	36	4	719	4	GBA3	4	22749341	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	5143109	22749341	168404935	41	8567										
AFM	173	broad.mit.edu	37	chr4	74357676	74357676	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaaagaaaataccagagcgcGgccagtgcataattaactca	8	9	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:74357676G>T	uc003hhb.2	+	8	962	c.931G>T	c.(931-933)GGC>TGC	p.G311C		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	311	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACCAGAGCGCGGCCAGTGCAT	0.358													1	0	1.85244e-09	0.083992	1.96249e-09	23	38										T	74357676	G	T	74357676	3	4	34	1	0	0	0	0	1	0	0	0	361	1116	39	4	961	4	AFM	4	74357676	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	51608335	74357676	116796600	42	8568										
PPBP	5473	broad.mit.edu	37	chr4	74853045	74853045	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tacaattttcttgattctggGagcatctgggtccaggcaga	11	8	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:74853045G>T	uc003hhj.2	-	3	411	c.331C>A	c.(331-333)CCC>ACC	p.P111T		NM_002704	NP_002695	P02775	CXCL7_HUMAN	pro-platelet basic protein precursor	111					chemotaxis|defense response to bacterium|immune response|platelet activation|platelet degranulation|positive regulation of cell division	extracellular space|platelet alpha granule lumen	chemokine activity|glucose transmembrane transporter activity|growth factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			TTGATTCTGGGAGCATCTGGG	0.428													1	0	4.88482e-21	0.048971	5.53096e-21	45	68										T	74853045	G	T	74853045	3	4	34	1	0	0	0	0	1	0	0	0	12303	1174	41	3	59	3	PPBP	4	74853045	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	495369	74853045	116301231	43	8569										
WDFY3	23001	broad.mit.edu	37	chr4	85781566	85781566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tctggcaacctggacttaccCtgttaaacactggcagcatc	8	13	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:85781566C>T	uc003hpd.2	-	4	587	c.179G>A	c.(178-180)AGG>AAG	p.R60K	WDFY3_uc003hpf.2_Missense_Mutation_p.R60K	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	60						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGGACTTACCCTGTTAAACAC	0.507													0	0	0	0.108266	0	25	57										T	85781566	C	T	85781566	3	4	34	1	0	0	0	0	1	0	0	0	17267	695	24	2	10704	2	WDFY3	4	85781566	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	10928521	85781566	105372710	44	8570										
TIGD2	166815	broad.mit.edu	37	chr4	90035429	90035429	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgatcagtggttcgactctcGgagcagtgactcaagctgtc	12	10	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:90035429G>T	uc003hsk.2	+	1	1462	c.1304G>T	c.(1303-1305)CGG>CTG	p.R435L	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	435					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		TTCGACTCTCGGAGCAGTGAC	0.443													1	0	1.7881e-09	0.037714	1.90375e-09	30	46										T	90035429	G	T	90035429	3	4	34	1	0	0	0	0	1	0	0	0	15893	1116	39	4	1306	4	TIGD2	4	90035429	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	4253863	90035429	101118847	45	8571										
CENPE	1062	broad.mit.edu	37	chr4	104061057	104061057	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gctacaattcttatttcttcAaggctttcatgaagtttctt	5	8	5	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:104061057A>G	uc003hxb.1	-	38	6183	c.6093T>C	c.(6091-6093)CTT>CTC	p.L2031L	CENPE_uc003hxc.1_Intron|CENPE_uc003hxd.1_Intron	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2031	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTATTTCTTCAAGGCTTTCAT	0.358													0	0	0	0.048971	0	47	96										G	104061057	A	G	104061057	2	3	34	1	0	0	0	0	0	0	0	1	3230	117	5	5		5	CENPE	4	104061057	Silent	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	14025628	104061057	87093219	46	8572										
FAT4	79633	broad.mit.edu	37	chr4	126412722	126412722	+	Frame_Shift_Del	DEL	C	C	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcaccaggcactgctgacaaCacactgcccatgaagctagg							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:126412722delC	uc003ifj.3	+	17	14745	c.14745delC	c.(14743-14745)AACfs	p.N4915fs	FAT4_uc011cgp.1_Frame_Shift_Del_p.N3156fs|FAT4_uc003ifi.1_Frame_Shift_Del_p.N2392fs	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4915	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGCTGACAACACACTGCCCA	0.552																		33	51	---	---								-	126412722	C	-	126412722	7	5	34	1	0	1	0	1	0	0	0	0	5692	477	17	0	14811	0	FAT4	4	126412722	Frame_Shift_Del	DEL	C	TCGA-CU-A0YN-01A-21D-A10S-08	22351665	126412722	64741554	47	8573										
RBM46	166863	broad.mit.edu	37	chr4	155719125	155719125	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgaaaatcgaggttatgcttTtgtgatgtacactacaaaag	9	5	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:155719125T>C	uc003ioo.2	+	3	487	c.314T>C	c.(313-315)TTT>TCT	p.F105S	RBM46_uc011cim.1_Missense_Mutation_p.F105S|RBM46_uc003iop.1_Missense_Mutation_p.F105S	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	105	RRM 1.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				GGTTATGCTTTTGTGATGTAC	0.353													0	0	0	0.039052	0	40	60										C	155719125	T	C	155719125	3	2	34	1	0	0	0	0	1	0	0	0	13140	1841	64	5	320	5	RBM46	4	155719125	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	29306403	155719125	35435151	48	8574										
TDO2	6999	broad.mit.edu	37	chr4	156838600	156838600	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gctgacttctcttatggacaTagattcactgatgaccaaat	7	9	2	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:156838600T>C	uc003ipf.1	+	10	1014	c.950T>C	c.(949-951)ATA>ACA	p.I317T		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	317					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	CTTATGGACATAGATTCACTG	0.418													0	0	0	0.048971	0	42	56										C	156838600	T	C	156838600	3	2	34	1	0	0	0	0	1	0	0	0	15724	1406	49	5	988	5	TDO2	4	156838600	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	1119475	156838600	34315676	49	8575										
ODZ3	55714	broad.mit.edu	37	chr4	183696288	183696288	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcccaagggaaagtcaatgtCtttggccgcaagctcagggt	13	10	3	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr4:183696288C>T	uc003ivd.1	+	23	5323	c.5286C>T	c.(5284-5286)GTC>GTT	p.V1762V		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1762	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AAGTCAATGTCTTTGGCCGCA	0.532													0	0	0	0.028581	0	15	32										T	183696288	C	T	183696288	2	4	34	1	0	0	0	0	0	0	0	1	10836	900	32	1		1	ODZ3	4	183696288	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	26857688	183696288	7457988	50	8576										
ADAMTS12	81792	broad.mit.edu	37	chr5	33576735	33576735	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggccaagtgatagggttgcgGgaagatgacaagccagaacc	15	8	0	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:33576735G>A	uc003jia.1	-	19	3559	c.3396C>T	c.(3394-3396)TCC>TCT	p.S1132S	ADAMTS12_uc010iuq.1_Silent_p.S1047S	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1132	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TAGGGTTGCGGGAAGATGACA	0.483										HNSCC(64;0.19)			0	0	0	0.083992	0	25	107										A	33576735	G	A	33576735	2	1	34	1	0	0	0	0	0	0	0	1	257	1219	43	2		2	ADAMTS12	5	33576735	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		33576735	147338525	51	8577										
AMACR	23600	broad.mit.edu	37	chr5	34008088	34008089	+	Frame_Shift_Del	DEL	CG	CG	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gaacgggcccggggccaggcCggacagctccacgaccgaga							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:34008088_34008089delCG	uc003jig.2	-	1	118_119	c.36_37delCG	c.(34-39)TCCGGCfs	p.S12fs	AMACR_uc003jih.2_Frame_Shift_Del_p.S12fs|AMACR_uc003jii.2_Frame_Shift_Del_p.S12fs|AMACR_uc003jij.2_Frame_Shift_Del_p.S12fs|AMACR_uc003jil.1_Frame_Shift_Del_p.S12fs|AMACR_uc003jik.1_Frame_Shift_Del_p.S12fs	NM_014324	NP_055139	Q9UHK6	AMACR_HUMAN	alpha-methylacyl-CoA racemase isoform 1	12_13					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	mitochondrion|peroxisomal matrix	alpha-methylacyl-CoA racemase activity				0						GGGGCCAGGCCGGACAGCTCCA	0.688																		15	71	---	---								-	34008089	CG	-	34008088	7	5	34	1	0	1	0	1	0	0	0	0	562	652	23	0	1461	0	AMACR	5	34008088	Frame_Shift_Del	DEL	CG	TCGA-CU-A0YN-01A-21D-A10S-08	431353	34008088	146907172	52	8578										
CARD6	84674	broad.mit.edu	37	chr5	40843579	40843579	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggacagagatatgaggagctAgatgattctttatacttagg	12	4	1	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:40843579A>G	uc003jmg.2	+	2	684	c.609A>G	c.(607-609)CTA>CTG	p.L203L		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	203	Asp/Glu-rich.				apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						ATGAGGAGCTAGATGATTCTT	0.393													0	0	0	0.024245	0	16	52										G	40843579	A	G	40843579	2	3	34	1	0	0	0	0	0	0	0	1	2650	407	15	5		5	CARD6	5	40843579	Silent	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	6835491	40843579	140071681	53	8579										
FBXO4	26272	broad.mit.edu	37	chr5	41927133	41927133	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agattgatgtacagctatatAttttgtcctttctttcacct	5	8	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:41927133A>G	uc003jmq.2	+	2	264	c.208A>G	c.(208-210)ATT>GTT	p.I70V	FBXO4_uc003jmp.2_Missense_Mutation_p.I70V|FBXO4_uc003jmr.2_Missense_Mutation_p.I70V	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	70	F-box.				positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				ACAGCTATATATTTTGTCCTT	0.333													0	0	0	0.048971	0	69	140										G	41927133	A	G	41927133	3	3	34	1	0	0	0	0	1	0	0	0	5748	449	16	5	214	5	FBXO4	5	41927133	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	1083554	41927133	138988127	54	8580										
VCAN	1462	broad.mit.edu	37	chr5	82816650	82816650	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatgaatggaaaggataaagAcatcccaagtttcactgaag	10	6	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:82816650A>T	uc003kii.3	+	7	2881	c.2525A>T	c.(2524-2526)GAC>GTC	p.D842V	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.D842V|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	842	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AAGGATAAAGACATCCCAAGT	0.423													0	0	0	0.049695	0	20	95										T	82816650	A	T	82816650	3	4	34	1	0	0	0	0	1	0	0	0	17135	275	10	5	2547	5	VCAN	5	82816650	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	40889517	82816650	98098610	55	8581										
MEF2C	4208	broad.mit.edu	37	chr5	88047694	88047694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctgtgttacctgcacttggaGgtcgatgtgttacaccagga	12	9	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:88047694G>A	uc003kjj.2	-	5	1242	c.569C>T	c.(568-570)CCT>CTT	p.P190L	MEF2C_uc003kji.2_Missense_Mutation_p.P190L|MEF2C_uc003kjk.2_Missense_Mutation_p.P190L|MEF2C_uc003kjm.2_Missense_Mutation_p.P188L|MEF2C_uc003kjl.2_Missense_Mutation_p.P208L	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	190					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		TGCACTTGGAGGTCGATGTGT	0.473										HNSCC(66;0.2)			0	0	0	0.037714	0	27	246										A	88047694	G	A	88047694	3	1	34	1	0	0	0	0	1	0	0	0	9457	1000	35	2	880	2	MEF2C	5	88047694	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	5231044	88047694	92867566	56	8582										
LRRTM2	26045	broad.mit.edu	37	chr5	138209838	138209838	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctgattaaaagacaggtccaAattttgcaggttaatcagtt	8	6	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:138209838A>C	uc011cyz.1	-	2	869	c.412T>G	c.(412-414)TTG>GTG	p.L138V	CTNNA1_uc003ldh.2_Intron|CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Intron|LRRTM2_uc010jez.2_Intron|LRRTM2_uc011cza.1_Intron|CTNNA1_uc003ldl.2_5'Flank	NM_015564	NP_056379	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	138	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GACAGGTCCAAATTTTGCAGG	0.398													0	0	0	0.038395	0	18	27										C	138209838	A	C	138209838	3	2	34	1	0	0	0	0	1	0	0	0	9040	11	1	5	1142	5	LRRTM2	5	138209838	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	50162144	138209838	42705422	57	8583										
PCDHB5	26167	broad.mit.edu	37	chr5	140517344	140517344	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	attcctaaccttttgccccaGggcgctggtgaagaaatagg	11	10	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:140517344G>T	uc003liq.2	+	1	2545	c.2328G>T	c.(2326-2328)CAG>CAT	p.Q776H		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	776	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTTGCCCCAGGGCGCTGGTG	0.502													1	0	2.06477e-34	0.048971	2.41454e-34	86	173										T	140517344	G	T	140517344	3	4	34	1	0	0	0	0	1	0	0	0	11545	991	35	4	2330	4	PCDHB5	5	140517344	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	2307506	140517344	40397916	58	8584										
PCDHGA10	56106	broad.mit.edu	37	chr5	140795157	140795157	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatgattcgaagtttcctatAgaggataccccattggttcc	9	9	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:140795157A>G	uc003lkl.1	+	1	2415	c.2415A>G	c.(2413-2415)ATA>ATG	p.I805M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.I805M|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	805	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTTCCTATAGAGGATACCC	0.393													0	0	0	0.105934	0	12	37										G	140795157	A	G	140795157	3	3	34	1	0	0	0	0	1	0	0	0	11551	410	15	5	2417	5	PCDHGA10	5	140795157	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	277813	140795157	40120103	59	8585										
ABLIM3	22885	broad.mit.edu	37	chr5	148632376	148632376	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggaagaaaccgactgcccaaGgatgtagacaggacccgttt	12	10	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:148632376G>T	uc003lpy.2	+	23	2165	c.1914G>T	c.(1912-1914)AAG>AAT	p.K638N	ABLIM3_uc003lpz.1_Missense_Mutation_p.K638N|ABLIM3_uc003lqa.1_Missense_Mutation_p.K535N|ABLIM3_uc003lqb.2_Missense_Mutation_p.K527N|ABLIM3_uc003lqc.1_Missense_Mutation_p.K605N|ABLIM3_uc003lqd.1_Missense_Mutation_p.K543N|ABLIM3_uc003lqf.2_Missense_Mutation_p.K527N|ABLIM3_uc003lqe.1_Missense_Mutation_p.K527N	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	638	HP.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTGCCCAAGGATGTAGACA	0.488													1	0	1.36615e-20	0.054565	1.53871e-20	34	98										T	148632376	G	T	148632376	3	4	34	1	0	0	0	0	1	0	0	0	96	991	35	4	2000	4	ABLIM3	5	148632376	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	7837219	148632376	32282884	60	8586										
FAT2	2196	broad.mit.edu	37	chr5	150934193	150934193	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atgcctaccaccaccctggaGgtggacttcagtgagggttc	12	12	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:150934193G>A	uc003lue.3	-	4	3688	c.3675C>T	c.(3673-3675)ACC>ACT	p.T1225T	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1225	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCACCCTGGAGGTGGACTTCA	0.517													0	0	0	0.083992	0	24	155										A	150934193	G	A	150934193	2	1	34	1	0	0	0	0	0	0	0	1	5690	987	35	2		2	FAT2	5	150934193	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	2301817	150934193	29981067	61	8587										
HK3	3101	broad.mit.edu	37	chr5	176314051	176314051	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaggagaaggtaaaacccagTgggaggctctgcccgctcag	14	10	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:176314051T>A	uc003mfa.2	-	13	1901	c.1809A>T	c.(1807-1809)CCA>CCT	p.P603P	HK3_uc003mez.2_Silent_p.P159P	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	603	Glucose-binding (Potential).|Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAAAACCCAGTGGGAGGCTCT	0.607													0	0	0	0.020292	0	14	41										A	176314051	T	A	176314051	2	1	34	1	0	0	0	0	0	0	0	1	7192	1683	59	5		5	HK3	5	176314051	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	25379858	176314051	4601209	62	8588										
SLC34A1	6569	broad.mit.edu	37	chr5	176813554	176813554	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acatccatcatcgtcagcatGgtctcctctggctgtgagtt	9	12	4	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr5:176813554G>A	uc003mgk.3	+	5	620	c.519G>A	c.(517-519)ATG>ATA	p.M173I		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	173	Helical; Name=M3; (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGTCAGCATGGTCTCCTCTG	0.647													0	0	0	0.043863	0	18	111										A	176813554	G	A	176813554	3	1	34	1	0	0	0	0	1	0	0	0	14567	1348	47	2	533	2	SLC34A1	5	176813554	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	499503	176813554	4101706	63	8589										
LY6G6F	259215	broad.mit.edu	37	chr6	31675681	31675681	+	Frame_Shift_Del	DEL	C	C	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgcaagggctgcagatggatCcccctgcaatgtcctcctgt							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:31675681delC	uc003nwa.1	+	3	416	c.416delC	c.(415-417)TCCfs	p.S139fs	BAT5_uc011dnz.1_Intron|LY6G6F_uc003nwb.1_Frame_Shift_Del_p.S139fs	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	139	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						GCAGATGGATCCCCCTGCAAT	0.602																		38	121	---	---								-	31675681	C	-	31675681	7	5	34	1	0	1	0	1	0	0	0	0	9096	855	30	0	426	0	LY6G6F	6	31675681	Frame_Shift_Del	DEL	C	TCGA-CU-A0YN-01A-21D-A10S-08		31675681	139439386	64	8590										
TTBK1	84630	broad.mit.edu	37	chr6	43226925	43226925	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gggccccagtccccaccttgTcccccaccccgggggtcctg	11	21	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:43226925T>C	uc003ouq.1	+	11	1445	c.1166T>C	c.(1165-1167)GTC>GCC	p.V389A		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	389						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCCCACCTTGTCCCCCACCCC	0.632													0	0	0	0.069234	0	10	81										C	43226925	T	C	43226925	3	2	34	1	0	0	0	0	1	0	0	0	16673	1667	58	5	1204	5	TTBK1	6	43226925	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	11551244	43226925	127888142	65	8591										
TMEM30A	55754	broad.mit.edu	37	chr6	75977363	75977363	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttggaaacacagacctcaaaTgacttttccagtgtgaagtt	8	8	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:75977363T>C	uc003phw.2	-	2	617	c.339A>G	c.(337-339)TCA>TCG	p.S113S	TMEM30A_uc003phx.2_Intron	NM_018247	NP_060717	Q9NV96	CC50A_HUMAN	transmembrane protein 30A isoform 1	113						integral to membrane					0						AGACCTCAAATGACTTTTCCA	0.358													0	0	0	0.074837	0	34	172										C	75977363	T	C	75977363	2	2	34	1	0	0	0	0	0	0	0	1	16150	1451	51	5		5	TMEM30A	6	75977363	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	32750438	75977363	95137704	66	8592										
TTK	7272	broad.mit.edu	37	chr6	80723066	80723066	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caagtggaaatgattcctgtGaattaagaaatttaaaggta	9	3	0	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:80723066G>T	uc003pjc.2	+	9	1041	c.967G>T	c.(967-969)GAA>TAA	p.E323*	TTK_uc003pjb.3_Nonsense_Mutation_p.E323*	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	323					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TGATTCCTGTGAATTAAGAAA	0.348													1	0	1.35964e-18	0.048971	1.50758e-18	44	127										T	80723066	G	T	80723066	4	4	34	1	0	0	0	0	0	1	0	0	16717	1291	45	3	997	3	TTK	6	80723066	Nonsense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	4745703	80723066	90392001	67	8593										
KIAA0776	23376	broad.mit.edu	37	chr6	96990871	96990871	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aagatgatgatagtgatgatGaatctcaatcatcccacact	7	8	2	6			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:96990871G>A	uc003por.2	+	12	1429	c.1381G>A	c.(1381-1383)GAA>AAA	p.E461K	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	461					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		TAGTGATGATGAATCTCAATC	0.373													0	0	0	0.048971	0	43	92										A	96990871	G	A	96990871	3	1	34	1	0	0	0	0	1	0	0	0	8193	1291	45	1	1427	1	KIAA0776	6	96990871	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	16267805	96990871	74124196	68	8594										
STXBP5	134957	broad.mit.edu	37	chr6	147704100	147704100	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aagaactgcggccatgttatCaagtgcagagtcattttcta	9	8	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:147704100C>G	uc003qlz.2	+	27	3541	c.3380C>G	c.(3379-3381)TCA>TGA	p.S1127*	STXBP5_uc010khz.1_Nonsense_Mutation_p.S1091*|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Nonsense_Mutation_p.S782*	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	1127	v-SNARE coiled-coil homology.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GCCATGTTATCAAGTGCAGAG	0.428													0	0	0	0.080422	0	38	53										G	147704100	C	G	147704100	4	3	34	1	0	0	0	0	0	1	0	0	15355	838	29	1	3486	1	STXBP5	6	147704100	Nonsense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	50713229	147704100	23410967	69	8595										
C6orf72	116254	broad.mit.edu	37	chr6	149893469	149893469	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgaaagatgatggggacataTctaaacagcaggtttgtctc	11	6	2	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:149893469T>C	uc003qmq.1	+	2	196	c.169T>C	c.(169-171)TCT>CCT	p.S57P	C6orf72_uc010kie.1_Intron	NM_138785	NP_620140	Q9NU53	CF072_HUMAN	hypothetical protein LOC116254 precursor	57	Extracellular (Potential).					integral to membrane					0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.66e-12)|GBM - Glioblastoma multiforme(68;0.171)		TGGGGACATATCTAAACAGCA	0.343													0	0	0	0.076483	0	25	51										C	149893469	T	C	149893469	3	2	34	1	0	0	0	0	1	0	0	0	2371	1435	50	5	175	5	C6orf72	6	149893469	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	2189369	149893469	21221598	70	8596										
PACRG	135138	broad.mit.edu	37	chr6	163235240	163235240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aaccaagcccacagcatttcGaaaattctatgagcgaggtg	9	10	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr6:163235240G>A	uc003qua.2	+	3	442	c.218G>A	c.(217-219)CGA>CAA	p.R73Q	PACRG_uc003qub.2_Missense_Mutation_p.R73Q|PACRG_uc003quc.2_Missense_Mutation_p.R73Q	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	73											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		ACAGCATTTCGAAAATTCTAT	0.468													0	0	0	0.039052	0	42	199										A	163235240	G	A	163235240	3	1	34	1	0	0	0	0	1	0	0	0	11370	1058	37	1	224	1	PACRG	6	163235240	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	13341771	163235240	7879827	71	8597										
C7orf36	57002	broad.mit.edu	37	chr7	39612007	39612007	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gaaatcaatcactccaccgtCccatgttgtagatttattgg	7	10	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:39612007C>G	uc003thc.3	+	3	392	c.383C>G	c.(382-384)TCC>TGC	p.S128C		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	128											0						ACTCCACCGTCCCATGTTGTA	0.373													0	0	0	0.042209	0	44	119										G	39612007	C	G	39612007	3	3	34	1	0	0	0	0	1	0	0	0	2390	855	30	1	393	1	C7orf36	7	39612007	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08		39612007	119526656	72	8598										
GCK	2645	broad.mit.edu	37	chr7	44190672	44190672	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cactcagagatgtagtcgaaGagctggaagatgcacgccat	12	9	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:44190672G>A	uc003tkl.2	-	4	836	c.366C>T	c.(364-366)CTC>CTT	p.L122L	GCK_uc003tkj.1_Silent_p.L121L|GCK_uc003tkk.1_Silent_p.L123L	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	122					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TGTAGTCGAAGAGCTGGAAGA	0.587													0	0	0	0.034045	0	30	44										A	44190672	G	A	44190672	2	1	34	1	0	0	0	0	0	0	0	1	6293	929	33	1		1	GCK	7	44190672	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	4578665	44190672	114947991	73	8599										
C7orf52	375607	broad.mit.edu	37	chr7	100817986	100817986	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cctgggctcggcctccacctCctgtggccgggtttcagagc	13	16	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:100817986C>T	uc003uxy.1	-	2	342	c.103G>A	c.(103-105)GAG>AAG	p.E35K	C7orf52_uc003uxz.1_Missense_Mutation_p.E35K|C7orf52_uc003uya.1_Missense_Mutation_p.E35K|C7orf52_uc003uyb.1_Missense_Mutation_p.E35K	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	35							N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					GCCTCCACCTCCTGTGGCCGG	0.637													0	0	0	0.069288	0	23	127										T	100817986	C	T	100817986	3	4	34	1	0	0	0	0	1	0	0	0	2401	864	30	1	1018	1	C7orf52	7	100817986	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	56627314	100817986	58320677	74	8600										
TFEC	22797	broad.mit.edu	37	chr7	115596823	115596823	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aattccttgttcaccgctatAcacatccaaaatacttccag	3	13	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:115596823A>T	uc003vhj.1	-	4	476	c.292T>A	c.(292-294)TAT>AAT	p.Y98N	TFEC_uc003vhk.1_Missense_Mutation_p.Y69N|TFEC_uc003vhl.3_Missense_Mutation_p.Y69N|TFEC_uc011kmw.1_Missense_Mutation_p.Y188N|TFEC_uc003vhm.1_RNA	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	98	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			TCACCGCTATACACATCCAAA	0.323													0	0	0	0.069456	0	33	59										T	115596823	A	T	115596823	3	4	34	1	0	0	0	0	1	0	0	0	15799	391	14	5	771	5	TFEC	7	115596823	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	14778837	115596823	43541840	75	8601										
SMO	6608	broad.mit.edu	37	chr7	128850949	128850949	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cactgtgtcccacgacgggcCcgtgggtgagcctcacccct	12	17	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:128850949C>A	uc003vor.2	+	10	2076	c.1796C>A	c.(1795-1797)CCC>CAC	p.P599H	SMO_uc003vos.2_Missense_Mutation_p.P274H	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	599	Cytoplasmic (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						CACGACGGGCCCGTGGGTGAG	0.632			Mis		skin basal cell 								1	0	6.29468e-14	0.074837	6.83788e-14	38	89										A	128850949	C	A	128850949	3	1	34	1	0	0	0	0	1	0	0	0	14800	623	22	4	1834	4	SMO	7	128850949	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	13254126	128850949	30287714	76	8602										
TTC26	79989	broad.mit.edu	37	chr7	138822608	138822608	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgaagttcaaacgtcatgttGgggaagaagaagaggatact	13	4	2	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:138822608G>A	uc003vus.2	+	3	271	c.157G>A	c.(157-159)GGG>AGG	p.G53R	TTC26_uc003vuq.2_Missense_Mutation_p.G53R|TTC26_uc011kqm.1_Missense_Mutation_p.G53R|TTC26_uc003vur.3_Missense_Mutation_p.G53R|TTC26_uc011kqn.1_Missense_Mutation_p.G53R|TTC26_uc011kqo.1_Intron|TTC26_uc011kqp.1_5'UTR|TTC26_uc003vut.2_5'UTR|TTC26_uc011kqq.1_Missense_Mutation_p.G53R	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	53							binding			ovary(1)	1						ACGTCATGTTGGGGAAGAAGA	0.328													0	0	0	0.054565	0	30	105										A	138822608	G	A	138822608	3	1	34	1	0	0	0	0	1	0	0	0	16691	1348	47	2	167	2	TTC26	7	138822608	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	9971659	138822608	20316055	77	8603										
TRPV5	56302	broad.mit.edu	37	chr7	142622811	142622811	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agctcaccagctccttcactGgggtctgttccagaatttgg	10	12	3	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr7:142622811G>A	uc003wby.1	-	8	1199	c.935C>T	c.(934-936)CCA>CTA	p.P312L	TRPV5_uc003wbz.2_Missense_Mutation_p.P312L	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	312	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CTCCTTCACTGGGGTCTGTTC	0.527													0	0	0	0.021553	0	6	36										A	142622811	G	A	142622811	3	1	34	1	0	0	0	0	1	0	0	0	16596	1348	47	2	1286	2	TRPV5	7	142622811	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	3800203	142622811	16515852	78	8604										
DOCK5	80005	broad.mit.edu	37	chr8	25234819	25234819	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgtcgcttttcttccttttcAgtggtctgacaagccctgtg	9	11	3	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:25234819A>G	uc003xeg.2	+	38	3954	c.3817_splice	c.e38-2	p.W1273_splice	PPP2R2A_uc003xek.2_Splice_Site_p.W62_splice|DOCK5_uc003xei.2_Splice_Site_p.W843_splice|DOCK5_uc003xej.2_Splice_Site	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CTTCCTTTTCAGTGGTCTGAC	0.363													0	0	0	0.062417	0	22	24										G	25234819	A	G	25234819	5	3	34	1	0	0	0	0	0	0	1	0	4690	202	7	5	3965	5	DOCK5	8	25234819	Splice_Site	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08		25234819	121129203	79	8605										
SCARA3	51435	broad.mit.edu	37	chr8	27516466	27516466	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cgactggcagaactacacacGgctcttcagcggcctgcgca	11	15	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:27516466G>A	uc003xga.1	+	5	920	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	SCARA3_uc003xgb.1_Missense_Mutation_p.R260Q	NM_016240	NP_057324	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3 isoform 1	260	Extracellular (Potential).				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			skin(2)|ovary(1)|breast(1)	4		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		AACTACACACGGCTCTTCAGC	0.622													0	0	0	0.028581	0	15	25										A	27516466	G	A	27516466	3	1	34	1	0	0	0	0	1	0	0	0	13879	1116	39	2	797	2	SCARA3	8	27516466	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	2281647	27516466	118847556	80	8606										
ADHFE1	137872	broad.mit.edu	37	chr8	67357551	67357551	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cacctgtaaggctgctaatcTgtatgcatccagccctcatt	7	13	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:67357551T>A	uc003xwb.3	+	6	486	c.452T>A	c.(451-453)CTG>CAG	p.L151Q	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.L103Q|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Missense_Mutation_p.L81Q|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	151					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			GCTGCTAATCTGTATGCATCC	0.493													0	0	0	0.058154	0	10	247										A	67357551	T	A	67357551	3	1	34	1	0	0	0	0	1	0	0	0	314	1580	55	5	474	5	ADHFE1	8	67357551	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	39841085	67357551	79006471	81	8607										
PRDM14	63978	broad.mit.edu	37	chr8	70981498	70981498	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cagaacgaagtgcaggtcctCctccgtgaactggaaccgag	12	12	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:70981498C>G	uc003xym.2	-	2	800	c.598G>C	c.(598-600)GAG>CAG	p.E200Q		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TGCAGGTCCTCCTCCGTGAAC	0.602													0	0	0	0.092188	0	42	85										G	70981498	C	G	70981498	3	3	34	1	0	0	0	0	1	0	0	0	12455	864	30	1	1145	1	PRDM14	8	70981498	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	3623947	70981498	75382524	82	8608										
DCAF4L2	138009	broad.mit.edu	37	chr8	88885212	88885212	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcagtcctggcccacggccgCcacgactccttcttcttcgt	9	18	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:88885212C>A	uc003ydz.2	-	1	1085	c.988G>T	c.(988-990)GCG>TCG	p.A330S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	330	WD 2.									ovary(1)	1						CCCACGGCCGCCACGACTCCT	0.567													1	0	1.21669e-08	0.059317	1.27633e-08	32	56										A	88885212	C	A	88885212	3	1	34	1	0	0	0	0	1	0	0	0	4272	739	26	4	203	4	DCAF4L2	8	88885212	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	17903714	88885212	57478810	83	8609										
TRHR	7201	broad.mit.edu	37	chr8	110100523	110100523	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caacagcacagtatcttcaaGgaagcaggtaagcaaaactg	9	9	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:110100523G>A	uc003ymz.3	+	1	798	c.782G>A	c.(781-783)AGG>AAG	p.R261K		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	261	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GTATCTTCAAGGAAGCAGGTA	0.383													0	0	0	0.028581	0	16	46										A	110100523	G	A	110100523	3	1	34	1	0	0	0	0	1	0	0	0	16477	1000	35	2	784	2	TRHR	8	110100523	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	21215311	110100523	36263499	84	8610										
CSMD3	114788	broad.mit.edu	37	chr8	113657416	113657416	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cgggtaaccaggtgataagaTtgttccactaggccctctaa	10	10	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr8:113657416T>C	uc003ynu.2	-	20	3391	c.3232A>G	c.(3232-3234)ATC>GTC	p.I1078V	CSMD3_uc003yns.2_Missense_Mutation_p.I350V|CSMD3_uc003ynt.2_Missense_Mutation_p.I1038V|CSMD3_uc011lhx.1_Missense_Mutation_p.I974V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1078	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTGATAAGATTGTTCCACTA	0.398										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.099896	0	26	48										C	113657416	T	C	113657416	3	2	34	1	0	0	0	0	1	0	0	0	3946	1493	52	5	8099	5	CSMD3	8	113657416	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	3556893	113657416	32706606	85	8611										
KIAA2026	158358	broad.mit.edu	37	chr9	6007430	6007430	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	accgccccggcccccgctgcGcggcccttccgccacctcct	9	25	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr9:6007430G>A	uc003zjq.3	-	1	574	c.358C>T	c.(358-360)CGC>TGC	p.R120C		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	120										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCCCCGCTGCGCGGCCCTTCC	0.726													0	0	0	0.004672	0	3	23										A	6007430	G	A	6007430	3	1	34	1	0	0	0	0	1	0	0	0	8270	1087	38	2	5985	2	KIAA2026	9	6007430	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		6007430	135206001	86	8612										
ZCCHC6	79670	broad.mit.edu	37	chr9	88953842	88953842	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acaagcattttcatttcctgCgctcactttacacagaagac	5	12	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr9:88953842C>T	uc004aoq.2	-	9	1446	c.1231G>A	c.(1231-1233)GCA>ACA	p.A411T	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Intron|ZCCHC6_uc004aou.2_Missense_Mutation_p.A411T|ZCCHC6_uc004aov.2_Missense_Mutation_p.A411T	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	411					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TCATTTCCTGCGCTCACTTTA	0.433													0	0	0	0.028581	0	15	60										T	88953842	C	T	88953842	3	4	34	1	0	0	0	0	1	0	0	0	17589	768	27	2	3332	2	ZCCHC6	9	88953842	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	82946412	88953842	52259589	87	8613										
RABEPK	10244	broad.mit.edu	37	chr9	127996239	127996239	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gggaaatctatgacgattgtAttgtgactgtagtggactaa	12	4	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr9:127996239A>G	uc004bpi.2	+	9	1272	c.1099A>G	c.(1099-1101)ATT>GTT	p.I367V	RABEPK_uc004bpj.2_Missense_Mutation_p.I316V|RABEPK_uc004bpk.2_Missense_Mutation_p.I367V|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.I367V	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	367					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TGACGATTGTATTGTGACTGT	0.388													0	0	0	0.048971	0	96	206										G	127996239	A	G	127996239	3	3	34	1	0	0	0	0	1	0	0	0	12963	449	16	5	1125	5	RABEPK	9	127996239	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	39042397	127996239	13217192	88	8614										
C9orf50	375759	broad.mit.edu	37	chr9	132375441	132375441	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggaggctgcttcgcggcctcTgagcagcggccttcttccat	13	14	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr9:132375441T>C	uc004byc.3	-	6	1335	c.1133A>G	c.(1132-1134)CAG>CGG	p.Q378R	C9orf50_uc004byb.3_RNA	NM_199350	NP_955382	Q5SZB4	CI050_HUMAN	hypothetical protein LOC375759	378										ovary(1)|central_nervous_system(1)	2		Ovarian(14;0.00556)				TCGCGGCCTCTGAGCAGCGGC	0.607													0	0	0	0.104719	0	38	101										C	132375441	T	C	132375441	3	2	34	1	0	0	0	0	1	0	0	0	2487	1580	55	5	170	5	C9orf50	9	132375441	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	4379202	132375441	8837990	89	8615										
LAMC3	10319	broad.mit.edu	37	chr9	133911631	133911631	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgccggtgccagcacaacacCaccggcacagactgtgagcg	12	15	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr9:133911631C>T	uc004caa.1	+	4	986	c.888C>T	c.(886-888)ACC>ACT	p.T296T		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	296	Laminin EGF-like 1.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGCACAACACCACCGGCACAG	0.682													0	0	0	0.069456	0	17	56										T	133911631	C	T	133911631	2	4	34	1	0	0	0	0	0	0	0	1	8616	581	21	2		2	LAMC3	9	133911631	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	1536190	133911631	7301800	90	8616										
FCN2	2220	broad.mit.edu	37	chr9	137777143	137777143	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttcctgagcggctggcacacCatctacctgcccgactgccg	10	17	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr9:137777143C>A	uc004cfg.1	+	5	370	c.360C>A	c.(358-360)ACC>ACA	p.T120T	FCN2_uc004cfh.1_Silent_p.T82T	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	120	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		GCTGGCACACCATCTACCTGC	0.677													1	0	1.05317e-09	0.020292	1.12689e-09	14	46										A	137777143	C	A	137777143	2	1	34	1	0	0	0	0	0	0	0	1	5792	581	21	4		4	FCN2	9	137777143	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	3865512	137777143	3436288	91	8617										
RBM17	84991	broad.mit.edu	37	chr10	6155497	6155497	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccaagaagtcagattcaaatCcgctgactgaaatacttaag	7	9	2	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:6155497C>G	uc001ijb.2	+	9	1109	c.883C>G	c.(883-885)CCG>GCG	p.P295A	RBM17_uc010qav.1_Missense_Mutation_p.P295A|RBM17_uc001ijc.2_5'Flank	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	295					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						AGATTCAAATCCGCTGACTGA	0.408													0	0	0	0.104719	0	40	144										G	6155497	C	G	6155497	3	3	34	1	0	0	0	0	1	0	0	0	13119	855	30	1	913	1	RBM17	10	6155497	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08		6155497	129379250	92	8618										
ITGA8	8516	broad.mit.edu	37	chr10	15600156	15600156	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atgaggaatagtagagtttcGcaaaaaggcgctgagctcag	13	6	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:15600156G>A	uc001ioc.1	-	26	2683	c.2683C>T	c.(2683-2685)CGA>TGA	p.R895*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.R880*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	895	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.R895Q(1)		ovary(3)|lung(3)	6						GTAGAGTTTCGCAAAAAGGCG	0.473													0	0	0	0.028581	0	16	109										A	15600156	G	A	15600156	4	1	34	1	0	0	0	0	0	1	0	0	7882	1095	38	2	528	2	ITGA8	10	15600156	Nonsense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	9444659	15600156	119934591	93	8619										
ITGA8	8516	broad.mit.edu	37	chr10	15760853	15760853	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gctcccccttccacgatatcGggctggctggtgttggcttt	12	13	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:15760853G>A	uc001ioc.1	-	2	255	c.255C>T	c.(253-255)CCC>CCT	p.P85P	ITGA8_uc010qcb.1_Silent_p.P85P	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	85	Extracellular (Potential).|FG-GAP 1.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CCACGATATCGGGCTGGCTGG	0.582													0	0	0	0.080422	0	35	114										A	15760853	G	A	15760853	2	1	34	1	0	0	0	0	0	0	0	1	7882	1103	39	2		2	ITGA8	10	15760853	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	160697	15760853	119773894	94	8620										
C10orf140	387640	broad.mit.edu	37	chr10	21804178	21804178	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cacaaatccccatctctcccAataatgagtgatggtggaca	7	12	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:21804178A>T	uc009xkd.2	-	4	4827	c.2574T>A	c.(2572-2574)ATT>ATA	p.I858I	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	777						nucleus	nucleotide binding			ovary(1)	1						CATCTCTCCCAATAATGAGTG	0.453													0	0	0	0.0333	0	18	54										T	21804178	A	T	21804178	2	4	34	1	0	0	0	0	0	0	0	1	1595	126	5	5		5	C10orf140	10	21804178	Silent	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	6043325	21804178	113730569	95	8621										
CSGALNACT2	55454	broad.mit.edu	37	chr10	43662480	43662480	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtgttttaccctgtggtgttCagtctttacaatcctgccat	8	10	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:43662480C>T	uc001jan.2	+	6	1523	c.1188C>T	c.(1186-1188)TTC>TTT	p.F396F		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	396	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						CTGTGGTGTTCAGTCTTTACA	0.373													0	0	0	0.038395	0	19	44										T	43662480	C	T	43662480	2	4	34	1	0	0	0	0	0	0	0	1	3939	825	29	1		1	CSGALNACT2	10	43662480	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	21858302	43662480	91872267	96	8622										
FAM21C	253725	broad.mit.edu	37	chr10	46245583	46245583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atgaggaagaggatgatgatGgctgtgacctttttgctgac	14	5	0	6			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:46245583G>A	uc001jcu.2	+	9	871	c.772G>A	c.(772-774)GGC>AGC	p.G258S	FAM21C_uc001jcs.1_Missense_Mutation_p.G203S|FAM21C_uc001jct.2_Missense_Mutation_p.G258S|FAM21C_uc010qfi.1_Missense_Mutation_p.G258S	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	258										ovary(1)	1						GGATGATGATGGCTGTGACCT	0.388													0	0	0	0.099896	0	24	117										A	46245583	G	A	46245583	3	1	34	1	0	0	0	0	1	0	0	0	5542	1348	47	2	806	2	FAM21C	10	46245583	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	2583103	46245583	89289164	97	8623										
ANK3	288	broad.mit.edu	37	chr10	61829047	61829047	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gaagtggcctttatgggaagTttggatttttgcctaatccc	11	7	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:61829047T>C	uc001jky.2	-	37	11784	c.11592A>G	c.(11590-11592)AAA>AAG	p.K3864K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3864					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTATGGGAAGTTTGGATTTTT	0.398													0	0	0	0.048971	0	108	328										C	61829047	T	C	61829047	2	2	34	1	0	0	0	0	0	0	0	1	622	1722	60	5		5	ANK3	10	61829047	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	15583464	61829047	73705700	98	8624										
COL13A1	1305	broad.mit.edu	37	chr10	71677085	71677085	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatgccaggcaagcatggagCcaaggtacctcccccttccc	10	16	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:71677085C>T	uc001jpr.1	+	17	1528	c.992C>T	c.(991-993)GCC>GTC	p.A331V	COL13A1_uc001jqj.1_Missense_Mutation_p.A331V|COL13A1_uc001jps.1_Missense_Mutation_p.A302V|COL13A1_uc001jpt.1_Missense_Mutation_p.A290V|COL13A1_uc001jpu.1_Missense_Mutation_p.A312V|COL13A1_uc001jpv.1_Missense_Mutation_p.A331V|COL13A1_uc001jpx.1_Missense_Mutation_p.A309V|COL13A1_uc001jpw.1_Missense_Mutation_p.A278V|COL13A1_uc001jpy.1_Missense_Mutation_p.A269V|COL13A1_uc001jpz.1_Missense_Mutation_p.A274V|COL13A1_uc001jqa.1_Missense_Mutation_p.A271V|COL13A1_uc001jqc.1_Missense_Mutation_p.A331V|COL13A1_uc001jqb.1_Missense_Mutation_p.A280V|COL13A1_uc001jql.2_Missense_Mutation_p.A331V|COL13A1_uc001jqd.1_Missense_Mutation_p.A319V|COL13A1_uc001jqe.1_Missense_Mutation_p.A314V|COL13A1_uc001jqf.1_Missense_Mutation_p.A312V|COL13A1_uc001jqg.1_Missense_Mutation_p.A309V|COL13A1_uc001jqh.1_Missense_Mutation_p.A331V|COL13A1_uc001jqi.1_Missense_Mutation_p.A331V|COL13A1_uc010qjf.1_Missense_Mutation_p.A121V|COL13A1_uc001jqk.1_Missense_Mutation_p.A169V	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	331	Extracellular (Potential).|Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	AAGCATGGAGCCAAGGTACCT	0.637													0	0	0	0.038147	0	8	46										T	71677085	C	T	71677085	3	4	34	1	0	0	0	0	1	0	0	0	3670	739	26	2	1062	2	COL13A1	10	71677085	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	9848038	71677085	63857662	99	8625										
PAOX	196743	broad.mit.edu	37	chr10	135203207	135203207	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcagtactgggggcgacctgGacctgctggctcagcccctc	14	15	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr10:135203207G>A	uc001lmv.2	+	6	1428	c.1348G>A	c.(1348-1350)GAC>AAC	p.D450N	PAOX_uc001lmw.2_Intron|PAOX_uc001lmx.2_Intron|PAOX_uc001lmy.2_Intron|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	588					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		GGGCGACCTGGACCTGCTGGC	0.741													0	0	0	0.028581	0	14	44										A	135203207	G	A	135203207	3	1	34	1	0	0	0	0	1	0	0	0	11423	1174	41	1	1370	1	PAOX	10	135203207	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	63526122	135203207	331540	100	8626										
CDHR5	53841	broad.mit.edu	37	chr11	618994	618994	+	Frame_Shift_Del	DEL	G	G	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aggtgctgttttctgcacccGggggccccccgggtgtggac							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:618994delG	uc001lqj.2	-	13	1670	c.1565delC	c.(1564-1566)CCGfs	p.P522fs	IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Intron|CDHR5_uc009ycc.2_Frame_Shift_Del_p.P356fs|CDHR5_uc009ycd.2_Frame_Shift_Del_p.P516fs|CDHR5_uc001lql.2_Frame_Shift_Del_p.P522fs	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	522	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TTCTGCACCCGGGGGCCCCCC	0.677																		50	208	---	---								-	618994	G	-	618994	7	5	34	1	0	1	0	1	0	0	0	0	3122	1116	39	0	984	0	CDHR5	11	618994	Frame_Shift_Del	DEL	G	TCGA-CU-A0YN-01A-21D-A10S-08		618994	134387522	101	8627										
NELL1	4745	broad.mit.edu	37	chr11	21592405	21592405	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgtgacaccagagtcacaagTcaatgtttagaccaaaatgg	9	8	2	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:21592405T>C	uc001mqe.2	+	18	2229	c.2076T>C	c.(2074-2076)AGT>AGC	p.S692S	NELL1_uc001mqf.2_Silent_p.S645S|NELL1_uc009yid.2_Silent_p.S720S|NELL1_uc010rdo.1_Silent_p.S635S|NELL1_uc010rdp.1_Silent_p.S405S|NELL1_uc001mqh.2_Silent_p.S237S	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	692	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GAGTCACAAGTCAATGTTTAG	0.468													0	0	0	0.11126	0	38	138										C	21592405	T	C	21592405	2	2	34	1	0	0	0	0	0	0	0	1	10333	1664	58	5		5	NELL1	11	21592405	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	20973411	21592405	113414111	102	8628										
CCDC73	493860	broad.mit.edu	37	chr11	32635179	32635179	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atgtatactggagttttctcAgtttttttatctgaagttga	8	4	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:32635179A>G	uc001mtv.2	-	16	2729	c.2685T>C	c.(2683-2685)ACT>ACC	p.T895T		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	895										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					GAGTTTTCTCAGTTTTTTTAT	0.398													0	0	0	0.048971	0	72	227										G	32635179	A	G	32635179	2	3	34	1	0	0	0	0	0	0	0	1	2846	175	7	5		5	CCDC73	11	32635179	Silent	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	11042774	32635179	102371337	103	8629										
HIPK3	10114	broad.mit.edu	37	chr11	33360345	33360345	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agacaggaatgaagtctaaaGaagccagaaaatacattttc	8	6	1	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:33360345G>A	uc001mul.1	+	5	1654	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	HIPK3_uc001mum.1_Missense_Mutation_p.E462K|HIPK3_uc009yjv.1_Missense_Mutation_p.E462K|HIPK3_uc009yjw.1_RNA	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	462	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						GAAGTCTAAAGAAGCCAGAAA	0.358													0	0	0	0.045705	0	32	99										A	33360345	G	A	33360345	3	1	34	1	0	0	0	0	1	0	0	0	7118	943	33	1	1398	1	HIPK3	11	33360345	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	725166	33360345	101646171	104	8630										
TRIM48	79097	broad.mit.edu	37	chr11	55036744	55036744	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtccgtgctgctgcacatgcCccagcctctgaatctagcgc	10	16	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:55036744C>T	uc010rid.1	+	5	691	c.605C>T	c.(604-606)CCC>CTC	p.P202L		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	186						intracellular	zinc ion binding				0						CTGCACATGCCCCAGCCTCTG	0.502													0	0	0	0.086207	0	35	74										T	55036744	C	T	55036744	3	4	34	1	0	0	0	0	1	0	0	0	16520	623	22	2	623	2	TRIM48	11	55036744	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	21676399	55036744	79969772	105	8631										
OR5M9	390162	broad.mit.edu	37	chr11	56230095	56230095	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgctctacggattcctcagtGggtctcctgagatacatgaa	10	10	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:56230095G>T	uc010rjj.1	-	1	783	c.783C>A	c.(781-783)CCC>CCA	p.P261P		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ATTCCTCAGTGGGTCTCCTGA	0.493													1	0	2.46105e-21	0.045705	2.80141e-21	33	79										T	56230095	G	T	56230095	2	4	34	1	0	0	0	0	0	0	0	1	11177	1335	47	4		4	OR5M9	11	56230095	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	1193351	56230095	78776421	106	8632										
OR9G4	283189	broad.mit.edu	37	chr11	56510738	56510738	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtcaatgatatttttaccacAaaaatgcaggcggaatgtat	8	6	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:56510738A>G	uc010rjo.1	-	1	550	c.550T>C	c.(550-552)TGT>CGT	p.C184R		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TTTTTACCACAAAAATGCAGG	0.453													0	0	0	0.104719	0	42	72										G	56510738	A	G	56510738	3	3	34	1	0	0	0	0	1	0	0	0	11251	130	5	5	436	5	OR9G4	11	56510738	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	280643	56510738	78495778	107	8633										
P2RX3	5024	broad.mit.edu	37	chr11	57137457	57137457	+	Frame_Shift_Del	DEL	C	C	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caccgattcgggggccttctCcataggccactagggcctct							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:57137457delC	uc001nju.2	+	12	1257	c.1181delC	c.(1180-1182)TCCfs	p.S394fs		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	394	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GGGGCCTTCTCCATAGGCCAC	0.612																		14	63	---	---								-	57137457	C	-	57137457	7	5	34	1	0	1	0	1	0	0	0	0	11341	855	30	0	1227	0	P2RX3	11	57137457	Frame_Shift_Del	DEL	C	TCGA-CU-A0YN-01A-21D-A10S-08	626719	57137457	77869059	108	8634										
OR4D6	219983	broad.mit.edu	37	chr11	59224536	59224536	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttgtggtcttctttgctgtgTatgtagcaacagtcctggga	12	7	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:59224536T>C	uc010rku.1	+	1	103	c.103T>C	c.(103-105)TAT>CAT	p.Y35H		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTTGCTGTGTATGTAGCAAC	0.458													0	0	0	0.048971	0	47	123										C	59224536	T	C	59224536	3	2	34	1	0	0	0	0	1	0	0	0	11058	1638	57	5	105	5	OR4D6	11	59224536	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	2087079	59224536	75781980	109	8635										
SUV420H1	51111	broad.mit.edu	37	chr11	67942531	67942531	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttttattcttgttgagaaaaTagtgccgtgcccattcgcct	8	9	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:67942531T>C	uc001onm.1	-	5	753	c.497A>G	c.(496-498)TAT>TGT	p.Y166C	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_5'UTR|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.Y166C|SUV420H1_uc001onp.2_Missense_Mutation_p.Y166C|SUV420H1_uc010rqa.1_Missense_Mutation_p.Y143C|SUV420H1_uc001onq.2_Missense_Mutation_p.Y166C	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GTTGAGAAAATAGTGCCGTGC	0.348													0	0	0	0.099896	0	23	48										C	67942531	T	C	67942531	3	2	34	1	0	0	0	0	1	0	0	0	15411	1406	49	5	2196	5	SUV420H1	11	67942531	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	8717995	67942531	67063985	110	8636										
ARAP1	116985	broad.mit.edu	37	chr11	72412744	72412744	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgccggcagaggcagtcttgTagaggaagccactgtggctc	15	10	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:72412744T>C	uc001osu.2	-	16	2441	c.2252A>G	c.(2251-2253)TAC>TGC	p.Y751C	ARAP1_uc001osv.2_Missense_Mutation_p.Y751C|ARAP1_uc001osr.2_Missense_Mutation_p.Y511C|ARAP1_uc001oss.2_Missense_Mutation_p.Y506C|ARAP1_uc009yth.2_Missense_Mutation_p.Y445C|ARAP1_uc010rre.1_Missense_Mutation_p.Y506C|ARAP1_uc001osw.1_Missense_Mutation_p.Y39C	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	751	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GGCAGTCTTGTAGAGGAAGCC	0.622													0	0	0	0.048971	0	48	143										C	72412744	T	C	72412744	3	2	34	1	0	0	0	0	1	0	0	0	838	1638	57	5	2180	5	ARAP1	11	72412744	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	4470213	72412744	62593772	111	8637										
CNTN5	53942	broad.mit.edu	37	chr11	99941209	99941209	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctcagttagacagtgggagcCctctccgatgggaatgtaag	13	9	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr11:99941209C>A	uc001pga.2	+	11	1555	c.1216C>A	c.(1216-1218)CCT>ACT	p.P406T	CNTN5_uc009ywv.1_Missense_Mutation_p.P406T|CNTN5_uc001pfz.2_Missense_Mutation_p.P406T|CNTN5_uc001pgb.2_Missense_Mutation_p.P332T	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	406	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CAGTGGGAGCCCTCTCCGATG	0.463													1	0	3.45872e-05	0.028581	3.55849e-05	16	18										A	99941209	C	A	99941209	3	1	34	1	0	0	0	0	1	0	0	0	3644	623	22	4	1250	4	CNTN5	11	99941209	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	27528465	99941209	35065307	112	8638										
RAD52	5893	broad.mit.edu	37	chr12	1034684	1034684	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acagtttccaagtgcattccCaaaactcctaagggcaagag	8	11	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:1034684C>A	uc001qis.1	-	7	589	c.475G>T	c.(475-477)GGG>TGG	p.G159W	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.G82W|RAD52_uc001qiu.1_Missense_Mutation_p.G159W|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Missense_Mutation_p.G159W|RAD52_uc001qix.1_Missense_Mutation_p.W209L	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	159					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			AGTGCATTCCCAAAACTCCTA	0.388								Homologous_recombination					1	0	5.35267e-07	0.043863	5.56054e-07	18	96										A	1034684	C	A	1034684	3	1	34	1	0	0	0	0	1	0	0	0	12991	594	21	4	805	4	RAD52	12	1034684	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08		1034684	132817211	113	8639										
SLC2A3	6515	broad.mit.edu	37	chr12	8083900	8083900	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gagagtgccaaaggcaccccGcagggcagtaggcgagatct	15	11	1	2	rs138143062		TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:8083900G>T	uc001qtr.2	-	4	713	c.451C>A	c.(451-453)CGG>AGG	p.R151R	SLC2A3_uc001qts.2_Silent_p.R151R	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	151	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		AAGGCACCCCGCAGGGCAGTA	0.507													1	0	2.26627e-22	0.09836	2.59349e-22	41	93										T	8083900	G	T	8083900	2	4	34	1	0	0	0	0	0	0	0	1	14545	1086	38	4		4	SLC2A3	12	8083900	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	7049216	8083900	125767995	114	8640										
NELL2	4753	broad.mit.edu	37	chr12	45269642	45269642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agaatgttctcagtaagaccCgagactccatggtgcggatc	11	10	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:45269642C>T	uc001rog.2	-	1	606	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	NELL2_uc001rof.3_5'Flank|NELL2_uc001roh.2_Missense_Mutation_p.R4Q|NELL2_uc009zkd.2_5'UTR|NELL2_uc010skz.1_Missense_Mutation_p.R54Q|NELL2_uc010sla.1_Missense_Mutation_p.R27Q|NELL2_uc001roi.1_Missense_Mutation_p.R4Q|NELL2_uc010slb.1_5'UTR|NELL2_uc001roj.2_Missense_Mutation_p.R4Q	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	4					cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CAGTAAGACCCGAGACTCCAT	0.517													0	0	0	0.043863	0	18	99										T	45269642	C	T	45269642	3	4	34	1	0	0	0	0	1	0	0	0	10334	652	23	2	2575	2	NELL2	12	45269642	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	37185742	45269642	88582253	115	8641										
LRP1	4035	broad.mit.edu	37	chr12	57600372	57600372	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtgacgagagtgtccgcattGatgctatggatgtccatgtc	13	8	0	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:57600372G>A	uc001snd.2	+	76	12173	c.11707G>A	c.(11707-11709)GAT>AAT	p.D3903N		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3903	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGTCCGCATTGATGCTATGGA	0.597													0	0	0	0.059317	0	35	45										A	57600372	G	A	57600372	3	1	34	1	0	0	0	0	1	0	0	0	8951	1290	45	1	12009	1	LRP1	12	57600372	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	12330730	57600372	76251523	116	8642										
C12orf12	196477	broad.mit.edu	37	chr12	91347836	91347836	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcgtcgtttccggaggatctGgctggggaggcctcgccgct	17	12	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:91347836G>A	uc001tbj.2	-	1	1118	c.684C>T	c.(682-684)GCC>GCT	p.A228A		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	228										central_nervous_system(1)|pancreas(1)	2						CGGAGGATCTGGCTGGGGAGG	0.627													0	0	0	0.048971	0	94	152										A	91347836	G	A	91347836	2	1	34	1	0	0	0	0	0	0	0	1	1676	1335	47	2		2	C12orf12	12	91347836	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	33747464	91347836	42504059	117	8643										
PWP1	11137	broad.mit.edu	37	chr12	108082471	108082471	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agagtgcacgcacccaggcaCgcccaagagagcccctggag	13	15	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:108082471C>T	uc001tmo.1	+	3	298	c.211C>T	c.(211-213)CGC>TGC	p.R71C	PWP1_uc001tmn.1_RNA|PWP1_uc009zuu.1_Missense_Mutation_p.R71C	NM_007062	NP_008993	Q13610	PWP1_HUMAN	periodic tryptophan protein 1	71					transcription, DNA-dependent	nucleus					0						CACCCAGGCACGCCCAAGAGA	0.517													0	0	0	0.050027	0	35	36										T	108082471	C	T	108082471	3	4	34	1	0	0	0	0	1	0	0	0	12843	536	19	2	221	2	PWP1	12	108082471	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	16734635	108082471	25769424	118	8644										
CAMKK2	10645	broad.mit.edu	37	chr12	121706440	121706440	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	acaaaggcccgccaaactcaCgtggaaagccggcctgccgg	12	15	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr12:121706440C>T	uc001tzu.2	-	5	749	c.625_splice	c.e5+1	p.R209_splice	CAMKK2_uc001tzt.2_Splice_Site_p.R209_splice|CAMKK2_uc001tzv.2_Splice_Site_p.R209_splice|CAMKK2_uc001tzw.2_Splice_Site_p.R209_splice|CAMKK2_uc001tzx.2_Splice_Site_p.R209_splice|CAMKK2_uc001tzy.2_Splice_Site_p.R209_splice|CAMKK2_uc001uaa.1_Splice_Site_p.R209_splice|CAMKK2_uc001uab.2_Splice_Site_p.R209_splice|CAMKK2_uc001uac.2_Splice_Site_p.R209_splice	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase						calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GCCAAACTCACGTGGAAAGCC	0.488													0	0	0	0.048971	0	70	219										T	121706440	C	T	121706440	5	4	34	1	0	0	0	0	0	0	1	0	2607	550	19	2	1202	2	CAMKK2	12	121706440	Splice_Site	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	13623969	121706440	12145455	119	8645										
SACS	26278	broad.mit.edu	37	chr13	23909550	23909550	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tacttgaaaagcctgatctaTtacaaattagccacgtagta	6	8	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:23909550T>C	uc001uon.2	-	10	9054	c.8465A>G	c.(8464-8466)AAT>AGT	p.N2822S	SACS_uc001uoo.2_Missense_Mutation_p.N2675S|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2822					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCCTGATCTATTACAAATTAG	0.388													0	0	0	0.069288	0	22	154										C	23909550	T	C	23909550	3	2	34	1	0	0	0	0	1	0	0	0	13804	1493	52	5	5278	5	SACS	13	23909550	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08		23909550	91260328	120	8646										
ATP8A2	51761	broad.mit.edu	37	chr13	26273338	26273338	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gggcagccattactcagcacTgcactgaccttgggaatttg	11	11	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:26273338T>A	uc001uqk.2	+	25	2381	c.2239T>A	c.(2239-2241)TGC>AGC	p.C747S	ATP8A2_uc010tdi.1_Missense_Mutation_p.C707S|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.C297S	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	707	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TACTCAGCACTGCACTGACCT	0.453													0	0	0	0.048971	0	49	73										A	26273338	T	A	26273338	3	1	34	1	0	0	0	0	1	0	0	0	1193	1580	55	5	2337	5	ATP8A2	13	26273338	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	2363788	26273338	88896540	121	8647										
SLC7A1	6541	broad.mit.edu	37	chr13	30110084	30110084	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caaactcgccatagcacaggCcagccagcactgaggccagc	10	16	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:30110084C>T	uc001uso.2	-	3	629	c.242G>A	c.(241-243)GGC>GAC	p.G81D		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	81	Helical; (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	ATAGCACAGGCCAGCCAGCAC	0.617													0	0	0	0.038395	0	14	57										T	30110084	C	T	30110084	3	4	34	1	0	0	0	0	1	0	0	0	14692	739	26	2	1691	2	SLC7A1	13	30110084	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	3836746	30110084	85059794	122	8648										
HTR2A	3356	broad.mit.edu	37	chr13	47469988	47469988	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtgtcatcatttaattgcatTagggagttcgtagttgagct	11	5	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:47469988T>C	uc001vbq.2	-	1	188	c.54A>G	c.(52-54)CTA>CTG	p.L18L	HTR2A_uc001vbr.2_Intron|HTR2A_uc010acr.2_Silent_p.L18L	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	18	Extracellular (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TTAATTGCATTAGGGAGTTCG	0.403													0	0	0	0.043863	0	17	92										C	47469988	T	C	47469988	2	2	34	1	0	0	0	0	0	0	0	1	7441	1741	61	5		5	HTR2A	13	47469988	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	17359904	47469988	67699890	123	8649										
RB1	5925	broad.mit.edu	37	chr13	48947629	48947629	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atctgatttcctattttaacGtaagccatatatgaaacatt	4	7	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:48947629G>C	uc001vcb.2	+	12	1381	c.1215_splice	c.e12+1	p.N405_splice	RB1_uc010act.1_Splice_Site_p.N106_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(14)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.264		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.0918	0	24	189										C	48947629	G	C	48947629	5	2	34	1	0	0	0	0	0	0	1	0	13098	1159	40	4	1262	4	RB1	13	48947629	Splice_Site	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	1477641	48947629	66222249	124	8650										
UTP14C	9724	broad.mit.edu	37	chr13	52604079	52604079	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatgttcaggagctgcaccaGtgacaccaaagaggctgcaa	12	10	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:52604079G>A	uc001vgb.2	+	2	1674	c.1139G>A	c.(1138-1140)AGT>AAT	p.S380N	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	380					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		AGCTGCACCAGTGACACCAAA	0.537													0	0	0	0.080422	0	40	61										A	52604079	G	A	52604079	3	1	34	1	0	0	0	0	1	0	0	0	17093	1029	36	2	1141	2	UTP14C	13	52604079	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	3656450	52604079	62565799	125	8651										
TDRD3	81550	broad.mit.edu	37	chr13	61041463	61041463	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgaatgactctaacaccacaGttcttggtggtgaagtggaa	11	7	2	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:61041463G>T	uc001via.2	+	5	954	c.166G>T	c.(166-168)GTT>TTT	p.V56F	TDRD3_uc010aef.2_5'UTR|TDRD3_uc001vhz.3_Missense_Mutation_p.V56F|TDRD3_uc010aeg.2_Missense_Mutation_p.V149F|TDRD3_uc001vib.3_Missense_Mutation_p.V56F	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	56					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		TAACACCACAGTTCTTGGTGG	0.383													1	0	1.79293e-35	0.048971	2.11982e-35	70	107										T	61041463	G	T	61041463	3	4	34	1	0	0	0	0	1	0	0	0	15729	1029	36	4	463	4	TDRD3	13	61041463	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	8437384	61041463	54128415	126	8652										
PCDH9	5101	broad.mit.edu	37	chr13	67799771	67799771	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatttgtagtgcttggccagGtcaggactgttaggcttgaa	14	6	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr13:67799771G>A	uc001vik.2	-	2	3494	c.2802C>T	c.(2800-2802)GAC>GAT	p.D934D	PCDH9_uc001vil.2_Silent_p.D934D|PCDH9_uc010thl.1_Silent_p.D934D|PCDH9_uc001vin.3_Silent_p.D934D	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	934	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GCTTGGCCAGGTCAGGACTGT	0.507													0	0	0	0.069288	0	19	176										A	67799771	G	A	67799771	2	1	34	1	0	0	0	0	0	0	0	1	11518	1252	44	2		2	PCDH9	13	67799771	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	6758308	67799771	47370107	127	8653										
OR11H12	440153	broad.mit.edu	37	chr14	19377902	19377903	+	Frame_Shift_Ins	INS	-	-	A													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tggtcaacttcctttcagagINSaaaaaaaacatctcctttgc							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:19377902_19377903insA	uc010tkp.1	+	1	309_310	c.309_310insA	c.(307-312)GAGAAAfs	p.E103fs		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	103_104	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCCTTTCAGAGAAAAAAAACAT	0.386																		19	140	---	---								A	19377903	-	A	19377902	7	5	34	1	0	1	1	0	0	0	0	0	10927	933	33	0	311	0	OR11H12	14	19377902	Frame_Shift_Ins	INS	-	TCGA-CU-A0YN-01A-21D-A10S-08		19377902	87971638	128	8654										
OR4N5	390437	broad.mit.edu	37	chr14	20612221	20612221	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttcttgcattttcttggagcGggagagatgttcctcctcgt	11	9	2	1	rs138565527		TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:20612221G>T	uc010tla.1	+	1	327	c.327G>T	c.(325-327)GCG>GCT	p.A109A		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TTCTTGGAGCGGGAGAGATGT	0.488													1	0	1.21826e-31	0.048971	1.41689e-31	84	220										T	20612221	G	T	20612221	2	4	34	1	0	0	0	0	0	0	0	1	11079	1103	39	4		4	OR4N5	14	20612221	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	1234319	20612221	86737319	129	8655										
SALL2	6297	broad.mit.edu	37	chr14	21992660	21992660	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttccacagacattgcacttaTagggcctctcacccgtgtgg	9	13	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:21992660T>C	uc001wbe.2	-	2	1484	c.1202A>G	c.(1201-1203)TAT>TGT	p.Y401C	SALL2_uc010tly.1_Missense_Mutation_p.Y399C|SALL2_uc010tlz.1_Missense_Mutation_p.Y264C|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.Y266C|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	401	C2H2-type 2.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		ATTGCACTTATAGGGCCTCTC	0.532													0	0	0	0.030593	0	28	103										C	21992660	T	C	21992660	3	2	34	1	0	0	0	0	1	0	0	0	13811	1406	49	5	1825	5	SALL2	14	21992660	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	1380439	21992660	85356880	130	8656										
HECTD1	25831	broad.mit.edu	37	chr14	31637558	31637558	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtgcaaacactggcaataacCttttcaagtatatgggtgcc	9	9	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:31637558C>A	uc001wrc.1	-	10	2057	c.1568G>T	c.(1567-1569)AGG>ATG	p.R523M	HECTD1_uc001wrd.1_Missense_Mutation_p.R38M	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	523					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TGGCAATAACCTTTTCAAGTA	0.338													1	0	3.71514e-35	0.048971	4.36835e-35	83	274										A	31637558	C	A	31637558	3	1	34	1	0	0	0	0	1	0	0	0	7039	681	24	4	6400	4	HECTD1	14	31637558	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	9644898	31637558	75711982	131	8657										
CLEC14A	161198	broad.mit.edu	37	chr14	38724033	38724033	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgtgctcacaaatatgaagaCcacggcagaggaggagtcga	13	8	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:38724033C>T	uc001wum.1	-	1	1542	c.1195G>A	c.(1195-1197)GTC>ATC	p.V399I		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	399	Helical; (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		AATATGAAGACCACGGCAGAG	0.507													0	0	0	0.024245	0	12	49										T	38724033	C	T	38724033	3	4	34	1	0	0	0	0	1	0	0	0	3499	507	18	2	281	2	CLEC14A	14	38724033	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	7086475	38724033	68625507	132	8658										
ABCD4	5826	broad.mit.edu	37	chr14	74756769	74756769	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tcagtgaagaatggcttttgTggcaggaatagcaccccatg	12	8	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:74756769T>A	uc001xpr.2	-	13	1532	c.1380A>T	c.(1378-1380)CCA>CCT	p.P460P	ABCD4_uc001xps.2_Silent_p.P301P|ABCD4_uc001xpt.2_Silent_p.P301P|ABCD4_uc010tur.1_Silent_p.P356P	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	460	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		ATGGCTTTTGTGGCAGGAATA	0.597											OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.048971	0	50	71										A	74756769	T	A	74756769	2	1	34	1	0	0	0	0	0	0	0	1	63	1683	59	5		5	ABCD4	14	74756769	Silent	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	36032736	74756769	32592771	133	8659										
LTBP2	4053	broad.mit.edu	37	chr14	74988700	74988700	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	accccacgcggttgatgcagCgcccttttcccttgcagggg	12	15	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr14:74988700C>T	uc001xqa.2	-	17	3089	c.2702G>A	c.(2701-2703)CGC>CAC	p.R901H		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	901	EGF-like 5; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GTTGATGCAGCGCCCTTTTCC	0.627													0	0	0	0.014758	0	5	57										T	74988700	C	T	74988700	3	4	34	1	0	0	0	0	1	0	0	0	9074	768	27	2	2843	2	LTBP2	14	74988700	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	231931	74988700	32360840	134	8660										
HERC2	8924	broad.mit.edu	37	chr15	28421740	28421741	+	Missense_Mutation	DNP	CC	CC	AA													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	accatcaccccaggaaaataCcaaacctaggtttaagaaac							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:28421740_28421741CC>AA	uc001zbj.2	-	63	9625_9626	c.9519_9520GG>TT	c.(9517-9522)TTGGTA>TTTTTA	p.3173_3174LV>FL		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3173_3174	RCC1 10.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAGGAAAATACCAAACCTAGGT	0.495													0	0	0	0.004672	0	73	191										AA	28421741	CC	AA	28421740	3	1	34	1	0	0	0	0	1	0	0	0	7058	507	18	4	5108	4	HERC2	15	28421740	Missense_Mutation	DNP	CC	TCGA-CU-A0YN-01A-21D-A10S-08		28421740	74109652	135	8661										
TMEM62	80021	broad.mit.edu	37	chr15	43427845	43427845	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gctggatatcaaaggaaatcAtggtaagagccaagagccag	12	7	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:43427845A>G	uc001zqr.2	+	3	707	c.428A>G	c.(427-429)CAT>CGT	p.H143R	TMEM62_uc010bda.2_Missense_Mutation_p.H13R	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	143						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		AAAGGAAATCATGGTAAGAGC	0.408													0	0	0	0.014758	0	4	34										G	43427845	A	G	43427845	3	3	34	1	0	0	0	0	1	0	0	0	16186	217	8	5	438	5	TMEM62	15	43427845	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	15006105	43427845	59103547	136	8662										
GOLGA6B	55889	broad.mit.edu	37	chr15	72958135	72958136	+	Frame_Shift_Del	DEL	CC	CC	-													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tctcacaggagagtccttcaCcgtatatgaaagccaggggg							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:72958135_72958136delCC	uc010uks.1	+	16	1750_1751	c.1709_1710delCC	c.(1708-1710)ACCfs	p.T570fs	uc002aux.1_5'Flank|uc002auy.1_5'Flank	NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	570	Potential.										0						GAGTCCTTCACCGTATATGAAA	0.629																		8	168	---	---								-	72958136	CC	-	72958135	7	5	34	1	0	1	0	1	0	0	0	0	6558	507	18	0	1664	0	GOLGA6B	15	72958135	Frame_Shift_Del	DEL	CC	TCGA-CU-A0YN-01A-21D-A10S-08	29530290	72958135	29573257	137	8663										
CHRNA3	1136	broad.mit.edu	37	chr15	78893669	78893669	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatggcttctttgatttctgGtgacaaagcagagagggaca	13	6	2	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:78893669G>T	uc002bec.2	-	5	1501	c.1315C>A	c.(1315-1317)CCA>ACA	p.P439T	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Missense_Mutation_p.P439T	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	439	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						TTGATTTCTGGTGACAAAGCA	0.408													1	0	2.79145e-41	0.048971	3.31872e-41	65	148										T	78893669	G	T	78893669	3	4	34	1	0	0	0	0	1	0	0	0	3384	1261	44	4	295	4	CHRNA3	15	78893669	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	5935534	78893669	23637723	138	8664										
BNC1	646	broad.mit.edu	37	chr15	83935803	83935803	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcttgttggatacatgggggGgatccttagcttacttagag	14	6	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:83935803G>A	uc002bjt.1	-	3	308	c.220C>T	c.(220-222)CCC>TCC	p.P74S	BNC1_uc010uos.1_Missense_Mutation_p.P62S	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	74					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TACATGGGGGGGATCCTTAGC	0.423													0	0	0	0.038395	0	18	43										A	83935803	G	A	83935803	3	1	34	1	0	0	0	0	1	0	0	0	1474	1232	43	2	2776	2	BNC1	15	83935803	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	5042134	83935803	18595589	139	8665										
FAM169B	283777	broad.mit.edu	37	chr15	99023900	99023900	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttttagcttgttccttcacaGagtgaggtagaaaaaacatg	9	6	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:99023900G>A	uc002buk.1	-	4	363	c.113C>T	c.(112-114)TCT>TTT	p.S38F		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	38											0						TTCCTTCACAGAGTGAGGTAG	0.443													0	0	0	0.042209	0	42	60										A	99023900	G	A	99023900	3	1	34	1	0	0	0	0	1	0	0	0	5488	942	33	1	481	1	FAM169B	15	99023900	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	15088097	99023900	3507492	140	8666										
TTC23	64927	broad.mit.edu	37	chr15	99715294	99715294	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgaagcgacagcagcatgggCgacgatgtgtgccgagtctg	16	9	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:99715294C>T	uc002bur.2	-	9	1357	c.826G>A	c.(826-828)GCC>ACC	p.A276T	TTC23_uc002bus.2_Missense_Mutation_p.A276T|TTC23_uc002but.2_Missense_Mutation_p.A276T|TTC23_uc002buu.2_Missense_Mutation_p.A276T|TTC23_uc002buv.2_Missense_Mutation_p.A276T|TTC23_uc002bux.2_Missense_Mutation_p.A276T|TTC23_uc002buw.2_Missense_Mutation_p.A276T|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Missense_Mutation_p.A276T|TTC23_uc010bor.2_Missense_Mutation_p.A276T|TTC23_uc002buz.2_Missense_Mutation_p.A276T	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	276							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			GCAGCATGGGCGACGATGTGT	0.512													0	0	0	0.037714	0	27	53										T	99715294	C	T	99715294	3	4	34	1	0	0	0	0	1	0	0	0	16687	768	27	2	537	2	TTC23	15	99715294	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	691394	99715294	2816098	141	8667										
LASS3	204219	broad.mit.edu	37	chr15	101041925	101041925	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cagcaagagaaaagcatatgGaattgtcacgtataaatgag	10	5	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr15:101041925G>A	uc002bvz.2	-	4	632	c.130C>T	c.(130-132)CCA>TCA	p.P44S	LASS3_uc002bwa.2_Missense_Mutation_p.P55S|LASS3_uc002bwb.2_Missense_Mutation_p.P44S	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	44	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			AAAGCATATGGAATTGTCACG	0.393													0	0	0	0.047766	0	8	72										A	101041925	G	A	101041925	3	1	34	1	0	0	0	0	1	0	0	0	8640	1174	41	1	1061	1	LASS3	15	101041925	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	1326631	101041925	1489467	142	8668										
DNAH3	55567	broad.mit.edu	37	chr16	20966209	20966209	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caaataacatcttttgccacAtcaccgcctttgcacagctt	4	14	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:20966209A>G	uc010vbe.1	-	55	10997	c.10997T>C	c.(10996-10998)ATG>ACG	p.M3666T	DNAH3_uc010vbd.1_Missense_Mutation_p.M1101T	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3666	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTTTTGCCACATCACCGCCTT	0.527													0	0	0	0.048971	0	64	172										G	20966209	A	G	20966209	3	3	34	1	0	0	0	0	1	0	0	0	4603	217	8	5	1384	5	DNAH3	16	20966209	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08		20966209	69388544	143	8669										
DNAH3	55567	broad.mit.edu	37	chr16	21117941	21117941	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agggataccagctccttagtGttggcaggaacctcactgac	11	11	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:21117941G>T	uc010vbe.1	-	15	2154	c.2154C>A	c.(2152-2154)AAC>AAA	p.N718K	DNAH3_uc002die.2_Missense_Mutation_p.N658K	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	718	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCTCCTTAGTGTTGGCAGGAA	0.403													1	0	7.26314e-15	0.034045	7.97083e-15	27	72										T	21117941	G	T	21117941	3	4	34	1	0	0	0	0	1	0	0	0	4603	1368	48	4	10387	4	DNAH3	16	21117941	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	151732	21117941	69236812	144	8670										
IL21R	50615	broad.mit.edu	37	chr16	27460030	27460030	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggagtctgacggtgtgcccaAgcccagcttctggccgacag	14	13	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:27460030A>T	uc002doq.1	+	9	1276	c.1043A>T	c.(1042-1044)AAG>ATG	p.K348M	IL21R_uc002dor.1_Missense_Mutation_p.K348M|IL21R_uc002dos.1_Missense_Mutation_p.K348M|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	348	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GGTGTGCCCAAGCCCAGCTTC	0.627			T	BCL6	NHL								0	0	0	0.030593	0	25	79										T	27460030	A	T	27460030	3	4	34	1	0	0	0	0	1	0	0	0	7671	72	3	5	1073	5	IL21R	16	27460030	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	6342089	27460030	62894723	145	8671										
ZNF629	23361	broad.mit.edu	37	chr16	30793590	30793590	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aggaaagagaaagggcttttCgttgccgtgggtgagctgat	16	5	0	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:30793590C>T	uc002dzs.1	-	3	2267	c.2059G>A	c.(2059-2061)GAA>AAA	p.E687K		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	687					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			AAGGGCTTTTCGTTGCCGTGG	0.567													0	0	0	0.0333	0	17	25										T	30793590	C	T	30793590	3	4	34	1	0	0	0	0	1	0	0	0	18050	893	31	1	554	1	ZNF629	16	30793590	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	3333560	30793590	59561163	146	8672										
ZNF423	23090	broad.mit.edu	37	chr16	49671865	49671865	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cttggtccagccctgcccgtCatcccgcatcttcttctgcc	7	19	4	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:49671865C>T	uc002efs.2	-	5	1496	c.1198G>A	c.(1198-1200)GAC>AAC	p.D400N	ZNF423_uc010vgn.1_Missense_Mutation_p.D283N	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	400					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				CCCTGCCCGTCATCCCGCATC	0.627													0	0	0	0.069456	0	37	54										T	49671865	C	T	49671865	3	4	34	1	0	0	0	0	1	0	0	0	17895	826	29	1	2676	1	ZNF423	16	49671865	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	18878275	49671865	40682888	147	8673										
CDH8	1006	broad.mit.edu	37	chr16	61935121	61935122	+	Missense_Mutation	DNP	CC	CC	AA													0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gcacagtagcatgatagggtCcattaagaaactctggtgca							TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:61935121_61935122CC>AA	uc002eog.1	-	3	760_761	c.508_509GG>TT	c.(508-510)GGA>TTA	p.G170L		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	170	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ATGATAGGGTCCATTAAGAAAC	0.401													0	0	0	0.004672	0	37	69										AA	61935122	CC	AA	61935121	3	1	34	1	0	0	0	0	1	0	0	0	3116	855	30	3	1930	3	CDH8	16	61935121	Missense_Mutation	DNP	CC	TCGA-CU-A0YN-01A-21D-A10S-08	12263256	61935121	28419632	148	8674										
FOXC2	2303	broad.mit.edu	37	chr16	86601425	86601425	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgttcgagaacggcagcttcCtgcggcgccggcggcgcttc	15	14	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr16:86601425C>T	uc002fjq.2	+	1	569	c.484C>T	c.(484-486)CTG>TTG	p.L162L		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	162	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						CGGCAGCTTCCTGCGGCGCCG	0.667									Late-onset_Hereditary_Lymphedema				0	0	0	0.034045	0	28	46										T	86601425	C	T	86601425	2	4	34	1	0	0	0	0	0	0	0	1	5995	680	24	2		2	FOXC2	16	86601425	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	24666304	86601425	3753328	149	8675										
UNC45B	146862	broad.mit.edu	37	chr17	33479931	33479931	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gctccgagtgcagttctccaCagactcgagggtacagaaga	12	11	1	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr17:33479931C>T	uc002hja.2	+	5	498	c.401C>T	c.(400-402)ACA>ATA	p.T134I	UNC45B_uc002hjb.2_Missense_Mutation_p.T134I|UNC45B_uc002hjc.2_Missense_Mutation_p.T134I|UNC45B_uc010cto.2_Missense_Mutation_p.T134I	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	134					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				CAGTTCTCCACAGACTCGAGG	0.537													0	0	0	0.039052	0	39	222										T	33479931	C	T	33479931	3	4	34	1	0	0	0	0	1	0	0	0	16986	478	17	2	415	2	UNC45B	17	33479931	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08		33479931	47715279	150	8676										
UNC45B	146862	broad.mit.edu	37	chr17	33496943	33496943	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cagaaaaactggccaaacagTgtcgcaagtaagggggctgt	13	8	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr17:33496943T>G	uc002hja.2	+	11	1637	c.1540T>G	c.(1540-1542)TGT>GGT	p.C514G	UNC45B_uc002hjb.2_Missense_Mutation_p.C514G|UNC45B_uc002hjc.2_Missense_Mutation_p.C514G|UNC45B_uc010cto.2_Intron	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	514					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GGCCAAACAGTGTCGCAAGTA	0.582													0	0	0	0.045705	0	32	68										G	33496943	T	G	33496943	3	3	34	1	0	0	0	0	1	0	0	0	16986	1696	59	5	1578	5	UNC45B	17	33496943	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08	17012	33496943	47698267	151	8677										
KRT13	3860	broad.mit.edu	37	chr17	39659035	39659035	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtctgaatcatggcagtgttGgtagacacctccttgttcag	11	9	3	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr17:39659035G>A	uc002hwu.1	-	5	990	c.927C>T	c.(925-927)ACC>ACT	p.T309T	KRT13_uc002hwv.1_Silent_p.T309T|KRT13_uc002hww.2_Silent_p.T202T|KRT13_uc010wfr.1_Silent_p.T202T|KRT13_uc010cxo.2_Silent_p.T309T|KRT13_uc002hwx.1_Silent_p.T297T	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	309	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				TGGCAGTGTTGGTAGACACCT	0.567													0	0	0	0.048971	0	65	258										A	39659035	G	A	39659035	2	1	34	1	0	0	0	0	0	0	0	1	8450	1335	47	2		2	KRT13	17	39659035	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	6162092	39659035	41536175	152	8678										
STAT5B	6777	broad.mit.edu	37	chr17	40370182	40370182	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caattacttgcgggtgttctCgttcttgagcagagacttgg	12	8	2	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr17:40370182C>T	uc002hzh.2	-	9	1325	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	STAT5B_uc002hzi.3_Missense_Mutation_p.E386K	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	386					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	CGGGTGTTCTCGTTCTTGAGC	0.547													0	0	0	0.0333	0	17	26										T	40370182	C	T	40370182	3	4	34	1	0	0	0	0	1	0	0	0	15268	893	31	1	1251	1	STAT5B	17	40370182	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	711147	40370182	40825028	153	8679										
ABCA8	10351	broad.mit.edu	37	chr17	66871845	66871845	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ttaggagggcacccctttccGtgtttctaaaggtggcccgg	13	11	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr17:66871845G>A	uc002jhp.2	-	34	4459	c.4280C>T	c.(4279-4281)ACG>ATG	p.T1427M	ABCA8_uc002jhq.2_Missense_Mutation_p.T1467M|ABCA8_uc010wqq.1_Missense_Mutation_p.T1462M	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1427	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ACCCCTTTCCGTGTTTCTAAA	0.483													0	0	0	0.092188	0	39	54										A	66871845	G	A	66871845	3	1	34	1	0	0	0	0	1	0	0	0	38	1145	40	2	485	2	ABCA8	17	66871845	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	26501663	66871845	14323365	154	8680										
KCNJ2	3759	broad.mit.edu	37	chr17	68171213	68171213	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cgaaccaaccgctacagcatCgtctcttcagaagaagacgg	9	13	2	3			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr17:68171213C>T	uc010dfg.2	+	2	434	c.33C>T	c.(31-33)ATC>ATT	p.I11I	KCNJ2_uc002jir.2_Silent_p.I11I	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	11	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					GCTACAGCATCGTCTCTTCAG	0.512													0	0	0	0.086207	0	34	68										T	68171213	C	T	68171213	2	4	34	1	0	0	0	0	0	0	0	1	8051	874	31	1		1	KCNJ2	17	68171213	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	1299368	68171213	13023997	155	8681										
DTNA	1837	broad.mit.edu	37	chr18	32395882	32395882	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tttttatgcagaaaaaagtcAcgttaaatggtttcttggac	8	5	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr18:32395882A>T	uc010dmn.1	+	6	614	c.613A>T	c.(613-615)ACG>TCG	p.T205S	DTNA_uc002kxu.2_Missense_Mutation_p.T205S|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Missense_Mutation_p.T205S|DTNA_uc002kxw.2_Missense_Mutation_p.T205S|DTNA_uc002kxx.2_Missense_Mutation_p.T205S|DTNA_uc010dmj.2_Missense_Mutation_p.T205S|DTNA_uc002kxz.2_Missense_Mutation_p.T205S|DTNA_uc002kxy.2_Missense_Mutation_p.T205S|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.T205S|DTNA_uc002kyb.3_Missense_Mutation_p.T205S|DTNA_uc010dmm.2_Missense_Mutation_p.T205S|DTNA_uc010xby.1_5'Flank|DTNA_uc010dmo.2_5'Flank|DTNA_uc002kyd.3_5'Flank|DTNA_uc010xbz.1_5'Flank|DTNA_uc010xca.1_5'Flank|DTNA_uc002kye.2_5'Flank	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	205	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GAAAAAAGTCACGTTAAATGG	0.398													0	0	0	0.024245	0	15	149										T	32395882	A	T	32395882	3	4	34	1	0	0	0	0	1	0	0	0	4788	159	6	5	635	5	DTNA	18	32395882	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08		32395882	45681366	156	8682										
LINGO3	645191	broad.mit.edu	37	chr19	2290293	2290293	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cggctcggggcgcacggtcaGcgtggcgaagtaggtgtcgt	19	10	1	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:2290293G>A	uc010dsx.1	-	2	1611	c.1483C>T	c.(1483-1485)CTG>TTG	p.L495L	SPPL2B_uc010dsw.1_Intron|uc002lvo.1_5'UTR	NM_001101391	NP_001094861	P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	495	Extracellular (Potential).|Ig-like C2-type.					integral to membrane					0						CGCACGGTCAGCGTGGCGAAG	0.746													0	0	0	0.021553	0	6	15										A	2290293	G	A	2290293	2	1	34	1	0	0	0	0	0	0	0	1	8816	962	34	2		2	LINGO3	19	2290293	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		2290293	56838690	157	8683										
TMPRSS9	360200	broad.mit.edu	37	chr19	2413950	2413950	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	agagccctgtggtcagcaccCccaccaaatcgatgcaggcc	10	16	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:2413950C>T	uc010xgx.1	+	9	1405	c.1405C>T	c.(1405-1407)CCC>TCC	p.P469S	TMPRSS9_uc002lvv.1_Missense_Mutation_p.P503S	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	469	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCAGCACCCCCACCAAATC	0.607													0	0	0	0.009096	0	4	27										T	2413950	C	T	2413950	3	4	34	1	0	0	0	0	1	0	0	0	16250	623	22	2	1439	2	TMPRSS9	19	2413950	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	123657	2413950	56715033	158	8684										
LMNB2	84823	broad.mit.edu	37	chr19	2433947	2433947	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccgctgccacccgtgcccgtGcccaggacgcttgggccgct	13	19	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:2433947G>A	uc002lvy.2	-	8	1386	c.1299C>T	c.(1297-1299)GGC>GGT	p.G433G	LMNB2_uc002lwa.1_Silent_p.G453G	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	433	Tail.			LEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVS -> WRWRSPWQRPKRPGHGHGWQRWLPPGPAGLGLGQRH (in Ref. 5; AAA80979).		nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGCCCGTGCCCAGGACGC	0.711													0	0	0	0.021553	0	6	32										A	2433947	G	A	2433947	2	1	34	1	0	0	0	0	0	0	0	1	8850	1306	46	2		2	LMNB2	19	2433947	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	19997	2433947	56695036	159	8685										
LMNB2	84823	broad.mit.edu	37	chr19	2433965	2433965	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gtgcccaggacgcttgggccGctgcccaagggctcctccac	13	17	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:2433965G>A	uc002lvy.2	-	8	1368	c.1281C>T	c.(1279-1281)AGC>AGT	p.S427S	LMNB2_uc002lwa.1_Silent_p.S447S	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	427	Tail.			LEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVS -> WRWRSPWQRPKRPGHGHGWQRWLPPGPAGLGLGQRH (in Ref. 5; AAA80979).		nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCTTGGGCCGCTGCCCAAGG	0.716													0	0	0	0.014758	0	5	25										A	2433965	G	A	2433965	2	1	34	1	0	0	0	0	0	0	0	1	8850	1078	38	2		2	LMNB2	19	2433965	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	18	2433965	56695018	160	8686										
C19orf29	58509	broad.mit.edu	37	chr19	3623701	3623701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cccaccttattccagatgaaGgtgcccagcaggttgttgtc	10	12	0	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:3623701G>A	uc002lyh.2	-	2	680	c.627C>T	c.(625-627)ACC>ACT	p.T209T	C19orf29_uc010dtn.2_5'Flank|C19orf29_uc002lyi.3_Silent_p.T209T|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	209						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCAGATGAAGGTGCCCAGCA	0.592													0	0	0	0.004672	0	3	24										A	3623701	G	A	3623701	2	1	34	1	0	0	0	0	0	0	0	1	1918	987	35	2		2	C19orf29	19	3623701	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	1189736	3623701	55505282	161	8687										
MUC16	94025	broad.mit.edu	37	chr19	9067793	9067793	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gatgccagcatatctgtggtCttcactaggccagaggtggg	14	9	3	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:9067793C>G	uc002mkp.2	-	3	19857	c.19653G>C	c.(19651-19653)AAG>AAC	p.K6551N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6553	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TATCTGTGGTCTTCACTAGGC	0.483													0	0	0	0.076483	0	24	52										G	9067793	C	G	9067793	3	3	34	1	0	0	0	0	1	0	0	0	9973	912	32	1	24198	1	MUC16	19	9067793	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	5444092	9067793	50061190	162	8688										
ZNF490	57474	broad.mit.edu	37	chr19	12691722	12691722	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccacattgtttacattcataGggtttttctccaaaatgagt	6	8	2	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:12691722G>A	uc002mtz.2	-	5	1296	c.1167C>T	c.(1165-1167)CCC>CCT	p.P389P		NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACATTCATAGGGTTTTTCTC	0.393													0	0	0	0.076483	0	22	132										A	12691722	G	A	12691722	2	1	34	1	0	0	0	0	0	0	0	1	17938	987	35	2		2	ZNF490	19	12691722	Silent	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	3623929	12691722	46437261	163	8689										
NANOS3	342977	broad.mit.edu	37	chr19	13988556	13988556	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gacacaggacacaggccaccGccgaggaggaggaggaggag	18	10	0	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:13988556G>T	uc002mxj.3	+	1	607	c.494G>T	c.(493-495)CGC>CTC	p.R165L		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	146					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			ACAGGCCACCGCCGAGGAGGA	0.652													1	0	1.06961e-07	0.038147	1.11657e-07	8	4										T	13988556	G	T	13988556	3	4	34	1	0	0	0	0	1	0	0	0	10153	1087	38	4	496	4	NANOS3	19	13988556	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	1296834	13988556	45140427	164	8690										
RYR1	6261	broad.mit.edu	37	chr19	38931454	38931454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tcaagctctgcctggccgccGagggcttcggcaaccgcctg	13	16	2	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:38931454G>A	uc002oit.2	+	2	245	c.115G>A	c.(115-117)GAG>AAG	p.E39K	RYR1_uc002oiu.2_Missense_Mutation_p.E39K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	39	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCTGGCCGCCGAGGGCTTCGG	0.682													0	0	0	0.038147	0	7	27										A	38931454	G	A	38931454	3	1	34	1	0	0	0	0	1	0	0	0	13768	1059	37	1	121	1	RYR1	19	38931454	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	24942898	38931454	20197529	165	8691										
ZNF845	91664	broad.mit.edu	37	chr19	53854662	53854662	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	aggagcgaaacaatataaatGtgatgtgtgtggcaaggtct	13	4	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:53854662G>A	uc010ydv.1	+	4	851	c.734G>A	c.(733-735)TGT>TAT	p.C245Y	ZNF845_uc010ydw.1_Missense_Mutation_p.C245Y	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	245	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAATATAAATGTGATGTGTGT	0.368													0	0	0	0.108266	0	29	44										A	53854662	G	A	53854662	3	1	34	1	0	0	0	0	1	0	0	0	18188	1377	48	2	744	2	ZNF845	19	53854662	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	14923208	53854662	5274321	166	8692										
ZNF606	80095	broad.mit.edu	37	chr19	58491249	58491249	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ggactgataaacagttttgtCataatcattattttcacagg	7	6	3	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr19:58491249C>T	uc002qqw.2	-	7	1417	c.799G>A	c.(799-801)GAC>AAC	p.D267N	ZNF606_uc010yhp.1_Missense_Mutation_p.D177N	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		ACAGTTTTGTCATAATCATTA	0.338													0	0	0	0.048971	0	135	170										T	58491249	C	T	58491249	3	4	34	1	0	0	0	0	1	0	0	0	18029	826	29	1	1583	1	ZNF606	19	58491249	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	4636587	58491249	637734	167	8693										
DHX35	60625	broad.mit.edu	37	chr20	37662873	37662873	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atctataacgaagttatacaGacctccaagtactacatgag	6	9	1	2			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr20:37662873G>T	uc002xjh.2	+	21	1991	c.1980G>T	c.(1978-1980)CAG>CAT	p.Q660H	DHX35_uc010zwa.1_Missense_Mutation_p.Q505H|DHX35_uc010zwb.1_Missense_Mutation_p.Q505H|DHX35_uc010zwc.1_Missense_Mutation_p.Q629H	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	660						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AAGTTATACAGACCTCCAAGT	0.448													1	0	3.7963e-18	0.083992	4.18768e-18	23	82										T	37662873	G	T	37662873	3	4	34	1	0	0	0	0	1	0	0	0	4508	933	33	3	2062	3	DHX35	20	37662873	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08		37662873	25362647	168	8694										
ELMO2	63916	broad.mit.edu	37	chr20	45022241	45022241	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctgggtttggcaacgaccacCtatgcaagagaaaaacagta	10	9	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr20:45022241C>T	uc002xrt.1	-	5	330	c.120_splice	c.e5-1	p.G40_splice	ELMO2_uc002xru.1_Splice_Site_p.G40_splice|ELMO2_uc010zxr.1_Splice_Site_p.G40_splice|ELMO2_uc010zxs.1_Splice_Site|ELMO2_uc002xrx.1_Splice_Site_p.G40_splice	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2						apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CAACGACCACCTATGCAAGAG	0.453													0	0	0	0.048971	0	96	195										T	45022241	C	T	45022241	5	4	34	1	0	0	0	0	0	0	1	0	5066	695	24	2	2115	2	ELMO2	20	45022241	Splice_Site	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	7359368	45022241	18003279	169	8695										
ZNF831	128611	broad.mit.edu	37	chr20	57768011	57768011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ccatggaggcaagaaagccaGggaggtgggaatgggcagtg	19	6	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr20:57768011G>A	uc002yan.2	+	1	1937	c.1937G>A	c.(1936-1938)AGG>AAG	p.R646K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	646						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AAGAAAGCCAGGGAGGTGGGA	0.567													0	0	0	0.048971	0	46	127										A	57768011	G	A	57768011	3	1	34	1	0	0	0	0	1	0	0	0	18182	1000	35	2	1939	2	ZNF831	20	57768011	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	12745770	57768011	5257509	170	8696										
C20orf11	54994	broad.mit.edu	37	chr20	61572869	61572869	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	atcagaatgagttatgcagaAaaacccgatgaaatcacgaa	8	7	2	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr20:61572869A>G	uc002ydy.2	+	2	192	c.15A>G	c.(13-15)GAA>GAG	p.E5E		NM_017896	NP_060366	Q9NWU2	CT011_HUMAN	chromosome 20 open reading frame 11	5						nucleus	protein binding				0	Breast(26;5.68e-08)					GTTATGCAGAAAAACCCGATG	0.458													0	0	0	0.024245	0	15	50										G	61572869	A	G	61572869	2	3	34	1	0	0	0	0	0	0	0	1	2079	11	1	5		5	C20orf11	20	61572869	Silent	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	3804858	61572869	1452651	171	8697										
USP25	29761	broad.mit.edu	37	chr21	17203740	17203740	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gttccttatcgattacatgcCgttttagttcacgaaggcca	8	10	1	0	rs145101158		TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr21:17203740C>T	uc002yjy.1	+	16	2002	c.1785C>T	c.(1783-1785)GCC>GCT	p.A595A	USP25_uc011aby.1_Silent_p.A595A|USP25_uc002yjz.1_Silent_p.A595A|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	595					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		GATTACATGCCGTTTTAGTTC	0.373													0	0	0	0.069288	0	24	131										T	17203740	C	T	17203740	2	4	34	1	0	0	0	0	0	0	0	1	17053	639	23	2		2	USP25	21	17203740	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08		17203740	30926155	172	8698										
COL18A1	80781	broad.mit.edu	37	chr21	46910215	46910215	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	gttggagcagatggagtcccCgggttccccggcctccctgg	15	14	0	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr21:46910215C>T	uc011afs.1	+	19	3252	c.3231C>T	c.(3229-3231)CCC>CCT	p.P1077P	COL18A1_uc002zhg.2_Silent_p.P662P|COL18A1_uc002zhi.2_Silent_p.P842P	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1077	Triple-helical region 4 (COL4).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		ATGGAGTCCCCGGGTTCCCCG	0.677													0	0	0	0.02938	0	6	11										T	46910215	C	T	46910215	2	4	34	1	0	0	0	0	0	0	0	1	3675	639	23	2		2	COL18A1	21	46910215	Silent	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	29706475	46910215	1219680	173	8699										
DDTL	100037417	broad.mit.edu	37	chr22	24313540	24313540	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	cagatgcccaggagagataaTagaaggtaagaagtcatgtt	12	5	1	4			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chr22:24313540T>C	uc002zyy.3	+	3	427	c.350T>C	c.(349-351)ATA>ACA	p.I117T	DDT_uc011ajf.1_Intron	NM_001084393	NP_001077862	A6NHG4	DDTL_HUMAN	D-dopachrome tautomerase-like	117						cytoplasm	lyase activity				0						GGAGAGATAATAGAAGGTAAG	0.483													0	0	0	0.09836	0	43	65										C	24313540	T	C	24313540	3	2	34	1	0	0	0	0	1	0	0	0	4340	1406	49	5	360	5	DDTL	22	24313540	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08		24313540	26991026	174	8700										
FUNDC1	139341	broad.mit.edu	37	chrX	44401284	44401284	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	caaacactcgattccaccacTggtgtcttcttgcatactca	5	14	3	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chrX:44401284T>C	uc004dgc.2	-	2	235	c.92A>G	c.(91-93)CAG>CGG	p.Q31R		NM_173794	NP_776155	Q8IVP5	FUND1_HUMAN	FUN14 domain containing 1	31											0						ATTCCACCACTGGTGTCTTCT	0.408													0	0	0	0.038147	0	7	8										C	44401284	T	C	44401284	3	2	34	1	0	0	0	0	1	0	0	0	6097	1580	55	5	391	5	FUNDC1	23	44401284	Missense_Mutation	SNP	T	TCGA-CU-A0YN-01A-21D-A10S-08		44401284	110869276	175	8701										
PCDH11X	27328	broad.mit.edu	37	chrX	91132785	91132785	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctccacctgaattcagcctgGattgtcgtacaggcatgctg	10	12	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chrX:91132785G>C	uc004efk.1	+	2	2391	c.1546G>C	c.(1546-1548)GAT>CAT	p.D516H	PCDH11X_uc004efl.1_Missense_Mutation_p.D516H|PCDH11X_uc004efo.1_Missense_Mutation_p.D516H|PCDH11X_uc010nmv.1_Missense_Mutation_p.D516H|PCDH11X_uc004efm.1_Missense_Mutation_p.D516H|PCDH11X_uc004efn.1_Missense_Mutation_p.D516H|PCDH11X_uc004efh.1_Missense_Mutation_p.D516H|PCDH11X_uc004efj.1_Missense_Mutation_p.D516H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	516	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATTCAGCCTGGATTGTCGTAC	0.438													0	0	0	0.054565	0	36	27										C	91132785	G	C	91132785	3	2	34	1	0	0	0	0	1	0	0	0	11508	1174	41	1	1552	1	PCDH11X	23	91132785	Missense_Mutation	SNP	G	TCGA-CU-A0YN-01A-21D-A10S-08	46731501	91132785	64137775	176	8702										
ZMAT1	84460	broad.mit.edu	37	chrX	101138751	101138751	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	ctgctctttctctggcctttCtttgccttcttctaggtgtc	7	13	5	0			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chrX:101138751C>T	uc004eim.2	-	2	4633	c.1135G>A	c.(1135-1137)GAA>AAA	p.E379K	ZMAT1_uc011mrl.1_Missense_Mutation_p.E550K|ZMAT1_uc004ein.2_Missense_Mutation_p.E379K|ZMAT1_uc011mrm.1_Missense_Mutation_p.E379K	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	379						nucleus	zinc ion binding			ovary(1)	1						TCTGGCCTTTCTTTGCCTTCT	0.393													0	0	0	0.048971	0	68	59										T	101138751	C	T	101138751	3	4	34	1	0	0	0	0	1	0	0	0	17688	922	32	1	272	1	ZMAT1	23	101138751	Missense_Mutation	SNP	C	TCGA-CU-A0YN-01A-21D-A10S-08	10005966	101138751	54131809	177	8703										
ZMAT1	84460	broad.mit.edu	37	chrX	101141649	101141649	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0847457627118644	15	0.25387498623335	1.22341184867951	2.00194666147557	1.11500826715095	0.00489579257292174	0.0181843724137093	0	tgtgggaccggaacatatctAaagatgtaaaagcaatacta	9	6	1	1			TCGA-CU-A0YN-01A-21D-A10S-08	TCGA-CU-A0YN-11A-11D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	803ab221-b813-4bcc-95a9-1f686d172d3c	49028d3a-8afa-4a54-8e26-89e61f95c688	g.chrX:101141649A>G	uc004eim.2	-	1	3545	c.47T>C	c.(46-48)TTA>TCA	p.L16S	ZMAT1_uc011mrl.1_Missense_Mutation_p.L187S|ZMAT1_uc004ein.2_Missense_Mutation_p.L16S|ZMAT1_uc011mrm.1_Missense_Mutation_p.L16S	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	16						nucleus	zinc ion binding			ovary(1)	1						GAACATATCTAAAGATGTAAA	0.328													0	0	0	0.062417	0	20	17										G	101141649	A	G	101141649	3	3	34	1	0	0	0	0	1	0	0	0	17688	372	13	5	1364	5	ZMAT1	23	101141649	Missense_Mutation	SNP	A	TCGA-CU-A0YN-01A-21D-A10S-08	2898	101141649	54128911	178	8704										
ATAD3B	83858	broad.mit.edu	37	chr1	1423280	1423280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atgaagcagacgccttccttCggaagcgagccactgtgagt	12	11	0	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:1423280C>T	uc001afv.2	+	12	1353	c.1252C>T	c.(1252-1254)CGG>TGG	p.R418W	ATAD3B_uc001afx.2_Missense_Mutation_p.R372W|ATAD3B_uc001afy.2_5'Flank	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	418							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGCCTTCCTTCGGAAGCGAGC	0.622													0	0	0	0.09319	0	13	68										T	1423280	C	T	1423280	3	4	35	1	0	0	0	0	1	0	0	0	1074	875	31	1	1298	1	ATAD3B	1	1423280	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		1423280	247827341	1	8705										
NADK	65220	broad.mit.edu	37	chr1	1684482	1684482	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tggaggggagcgggtagcatGaggtagtgatgctgatgctg	20	4	0	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:1684482G>A	uc009vkw.2	-	12	1323	c.1202C>T	c.(1201-1203)TCA>TTA	p.S401L	NADK_uc001aic.2_Missense_Mutation_p.S401L|NADK_uc001aid.3_Missense_Mutation_p.S401L|NADK_uc001aie.2_Missense_Mutation_p.S546L|NADK_uc010nyv.1_Missense_Mutation_p.S369L	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	401					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CGGGTAGCATGAGGTAGTGAT	0.642													0	0	0	0.021553	0	3	19										A	1684482	G	A	1684482	3	1	35	1	0	0	0	0	1	0	0	0	10137	1294	45	1	142	1	NADK	1	1684482	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	261202	1684482	247566139	2	8706										
ARID1A	8289	broad.mit.edu	37	chr1	27059204	27059204	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atttgggtctcaggcatcctCagccccctcaatgacctcca	7	16	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:27059204C>T	uc001bmv.1	+	4	2214	c.1841C>T	c.(1840-1842)TCA>TTA	p.S614L	ARID1A_uc001bmt.1_Missense_Mutation_p.S614L|ARID1A_uc001bmu.1_Missense_Mutation_p.S614L|ARID1A_uc001bmw.1_Missense_Mutation_p.S231L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	614					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGGCATCCTCAGCCCCCTCA	0.478			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.038147	0	7	169										T	27059204	C	T	27059204	3	4	35	1	0	0	0	0	1	0	0	0	913	838	29	1	1855	1	ARID1A	1	27059204	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	25374722	27059204	222191417	3	8707										
ARID1A	8289	broad.mit.edu	37	chr1	27059260	27059260	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aagatatgaacctgagccttCagtcaagaccctccagcttg	8	12	2	4			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:27059260C>T	uc001bmv.1	+	4	2270	c.1897C>T	c.(1897-1899)CAG>TAG	p.Q633*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q633*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q633*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q250*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	633					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTGAGCCTTCAGTCAAGACC	0.488			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.132662	0	14	170										T	27059260	C	T	27059260	4	4	35	1	0	0	0	0	0	1	0	0	913	827	29	1	1911	1	ARID1A	1	27059260	Nonsense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	56	27059260	222191361	4	8708										
RLF	6018	broad.mit.edu	37	chr1	40661404	40661404	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aaacccagttcttcttaaaaTtctgtctcaacagccagtag	5	11	4	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:40661404T>G	uc001cfc.3	+	4	606	c.575T>G	c.(574-576)ATT>AGT	p.I192S		NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	192					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CTTCTTAAAATTCTGTCTCAA	0.368													0	0	0	0.02938	0	5	47										G	40661404	T	G	40661404	3	3	35	1	0	0	0	0	1	0	0	0	13389	1493	52	5	589	5	RLF	1	40661404	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	13602144	40661404	208589217	5	8709										
ECHDC2	55268	broad.mit.edu	37	chr1	53370432	53370432	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acgtgggcctcagttccactCagtcgtcggcccgtgaagat	12	13	2	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:53370432C>G	uc001cup.3	-	7	834	c.588G>C	c.(586-588)CTG>CTC	p.L196L	ECHDC2_uc001cun.2_Silent_p.L119L|ECHDC2_uc001cuo.3_Silent_p.L165L|ECHDC2_uc010onk.1_Silent_p.L150L	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	196					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						CAGTTCCACTCAGTCGTCGGC	0.677													0	0	0	0.105934	0	12	64										G	53370432	C	G	53370432	2	3	35	1	0	0	0	0	0	0	0	1	4894	813	29	1		1	ECHDC2	1	53370432	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	12709028	53370432	195880189	6	8710										
CD58	965	broad.mit.edu	37	chr1	117078842	117078842	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acaagttagtgtgggagatgGaagagactctggaaaaaaaa	13	3	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:117078842G>C	uc001egm.2	-	3	494	c.373C>G	c.(373-375)CCA>GCA	p.P125A	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Missense_Mutation_p.P125A|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Missense_Mutation_p.P125A	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	125	Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		GTGGGAGATGGAAGAGACTCT	0.358													0	0	0	0.014758	0	5	36										C	117078842	G	C	117078842	3	2	35	1	0	0	0	0	1	0	0	0	3025	1174	41	1	399	1	CD58	1	117078842	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	63708410	117078842	132171779	7	8711										
NUDT17	200035	broad.mit.edu	37	chr1	145588986	145588986	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acccaggtccacacctcgatCtgtgggcagctcagccccag	10	17	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:145588986C>T	uc001eoe.2	-	2	270	c.262G>A	c.(262-264)GAT>AAT	p.D88N	NBPF10_uc001emp.3_Intron|NUDT17_uc001eof.1_Missense_Mutation_p.D148N	NM_001012758	NP_001012776	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety	88							hydrolase activity|metal ion binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACACCTCGATCTGTGGGCAGC	0.637											OREG0013751	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.115264	0	3	15										T	145588986	C	T	145588986	3	4	35	1	0	0	0	0	1	0	0	0	10734	913	32	1	752	1	NUDT17	1	145588986	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	28510144	145588986	103661635	8	8712										
KIF14	9928	broad.mit.edu	37	chr1	200571154	200571154	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gcgggactaatcgtagcaatCattgcagtttttgaatttcc	9	8	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:200571154C>G	uc010ppk.1	-	11	2461	c.2022G>C	c.(2020-2022)ATG>ATC	p.M674I	KIF14_uc010ppj.1_Missense_Mutation_p.M183I	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	674					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TCGTAGCAATCATTGCAGTTT	0.348													0	0	0	0.160694	0	15	83										G	200571154	C	G	200571154	3	3	35	1	0	0	0	0	1	0	0	0	8276	826	29	1	3004	1	KIF14	1	200571154	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	54982168	200571154	48679467	9	8713										
TRIM67	440730	broad.mit.edu	37	chr1	231349602	231349603	+	Frame_Shift_Ins	INS	-	-	CCAC													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggggccaccgtgggcgtgctINSgctggacctgaataagcaca							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:231349602_231349603insCCAC	uc009xfn.1	+	9	2207_2208	c.2165_2166insCCAC	c.(2164-2166)CTGfs	p.L722fs		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	722	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GTGGGCGTGCTGCTGGACCTGA	0.614																		9	200	---	---								CCAC	231349603	-	CCAC	231349602	7	5	35	1	0	1	1	0	0	0	0	0	16537	1580	55	0	2199	0	TRIM67	1	231349602	Frame_Shift_Ins	INS	-	TCGA-CU-A0YO-01A-11D-A10S-08	30778448	231349602	17901019	10	8714										
OR2L2	26246	broad.mit.edu	37	chr1	248202245	248202245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gggttctccttgctgtctacCgcatgcactctgcagaaggg	12	12	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr1:248202245C>T	uc001idw.2	+	1	772	c.676C>T	c.(676-678)CGC>TGC	p.R226C	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGCTGTCTACCGCATGCACTC	0.488													0	0	0	0.163468	0	33	191										T	248202245	C	T	248202245	3	4	35	1	0	0	0	0	1	0	0	0	11007	652	23	2	678	2	OR2L2	1	248202245	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	16852643	248202245	1048376	11	8715										
FEZ2	9637	broad.mit.edu	37	chr2	36805997	36805998	+	Frame_Shift_Del	DEL	GC	GC	-													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atttaactcagacactgagaGccttttcactcctgtgacca							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr2:36805997_36805998delGC	uc002rph.2	-	5	692_693	c.645_646delGC	c.(643-648)AGGCTCfs	p.R215fs	FEZ2_uc002rpe.2_Frame_Shift_Del_p.R44fs|FEZ2_uc002rpf.2_Frame_Shift_Del_p.R44fs|FEZ2_uc002rpg.2_Frame_Shift_Del_p.R215fs|FEZ2_uc002rpi.2_Frame_Shift_Del_p.R70fs|FEZ2_uc002rpj.2_Frame_Shift_Del_p.R215fs	NM_005102	NP_005093	Q9UHY8	FEZ2_HUMAN	zygin 2 isoform 1	215_216	Potential.				axon guidance|signal transduction		protein binding			ovary(1)	1		all_hematologic(82;0.21)				GACACTGAGAGCCTTTTCACTC	0.396																		14	80	---	---								-	36805998	GC	-	36805997	7	5	35	1	0	1	0	1	0	0	0	0	5824	971	34	0	516	0	FEZ2	2	36805997	Frame_Shift_Del	DEL	GC	TCGA-CU-A0YO-01A-11D-A10S-08		36805997	206393376	12	8716										
SMYD1	150572	broad.mit.edu	37	chr2	88409880	88409880	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ctgtgtcccacaggccatgcGggtgcagacggagatggagc	16	11	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr2:88409880G>A	uc002ssr.2	+	10	1324	c.1322G>A	c.(1321-1323)CGG>CAG	p.R441Q	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Missense_Mutation_p.R137Q	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CAGGCCATGCGGGTGCAGACG	0.532													0	0	0	0.069234	0	10	24										A	88409880	G	A	88409880	3	1	35	1	0	0	0	0	1	0	0	0	14821	1116	39	2	1360	2	SMYD1	2	88409880	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	51603883	88409880	154789493	13	8717										
RND3	390	broad.mit.edu	37	chr2	151326590	151326590	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gctaggcatgtgtgaaatccGctttgtggctctctgtgatt	12	8	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr2:151326590G>A	uc002txe.2	-	5	890	c.646C>T	c.(646-648)CGG>TGG	p.R216W	RND3_uc002txf.2_Missense_Mutation_p.R215W|RND3_uc002txg.2_Missense_Mutation_p.R216W|RND3_uc010zbv.1_Intron|RND3_uc010zbw.1_Missense_Mutation_p.R79W	NM_005168	NP_005159	P61587	RND3_HUMAN	ras homolog gene family, member E precursor	216					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.106)		TGTGAAATCCGCTTTGTGGCT	0.438													0	0	0	0.038147	0	8	150										A	151326590	G	A	151326590	3	1	35	1	0	0	0	0	1	0	0	0	13421	1086	38	2	92	2	RND3	2	151326590	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	62916710	151326590	91872783	14	8718										
SPC25	57405	broad.mit.edu	37	chr2	169732631	169732631	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cgatctttatacaagtctgcAgatttctgcagccttttcaa	6	10	4	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr2:169732631A>G	uc002uel.2	-	5	533	c.402T>C	c.(400-402)TCT>TCC	p.S134S		NM_020675	NP_065726	Q9HBM1	SPC25_HUMAN	spindle pole body component 25	134	Potential.|Interaction with the N-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)	1						ACAAGTCTGCAGATTTCTGCA	0.284													0	0	0	0.115264	0	3	40										G	169732631	A	G	169732631	2	3	35	1	0	0	0	0	0	0	0	1	15021	175	7	5		5	SPC25	2	169732631	Silent	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	18406041	169732631	73466742	15	8719										
RFTN2	130132	broad.mit.edu	37	chr2	198540158	198540158	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gctgctatcatcagggtcttCtagctttctaagtccgcacc	8	13	5	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr2:198540158C>T	uc002uuo.3	-	1	427	c.25G>A	c.(25-27)GAA>AAA	p.E9K		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	9						plasma membrane					0						TCAGGGTCTTCTAGCTTTCTA	0.423													0	0	0	0.139131	0	74	189										T	198540158	C	T	198540158	3	4	35	1	0	0	0	0	1	0	0	0	13259	922	32	1	1516	1	RFTN2	2	198540158	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	28807527	198540158	44659215	16	8720										
HEG1	57493	broad.mit.edu	37	chr3	124728594	124728594	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ctggtacccaaccgggcattTgcagataaaggatccctgag	11	11	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr3:124728594T>C	uc003ehs.3	-	8	3216	c.3148A>G	c.(3148-3150)AAA>GAA	p.K1050E	HEG1_uc011bke.1_Missense_Mutation_p.K1150E	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	1050	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						ACCGGGCATTTGCAGATAAAG	0.428													0	0	0	0.058154	0	9	41										C	124728594	T	C	124728594	3	2	35	1	0	0	0	0	1	0	0	0	7044	1821	63	5	1037	5	HEG1	3	124728594	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08		124728594	73293836	17	8721										
STAG1	10274	broad.mit.edu	37	chr3	136088080	136088080	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tctctgccacctgtcattaaTtggtggctgaaaatcatcag	8	10	4	1	rs143784838	byFrequency	TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr3:136088080T>C	uc003era.1	-	24	2707	c.2415A>G	c.(2413-2415)CAA>CAG	p.Q805Q	STAG1_uc003erb.1_Silent_p.Q805Q|STAG1_uc003erc.1_Silent_p.Q579Q	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	805					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						CTGTCATTAATTGGTGGCTGA	0.393													0	0	0	0.043863	0	18	84										C	136088080	T	C	136088080	2	2	35	1	0	0	0	0	0	0	0	1	15241	1490	52	5		5	STAG1	3	136088080	Silent	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	11359486	136088080	61934350	18	8722										
RBP2	5948	broad.mit.edu	37	chr3	139181129	139181129	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tcttgcgggtggcaaaatcaAtatctgttggcaaagggagt	13	6	3	0	rs142756165		TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr3:139181129A>G	uc003eth.2	-	2	128	c.77T>C	c.(76-78)ATT>ACT	p.I26T		NM_004164	NP_004155	P50120	RET2_HUMAN	retinol binding protein 2, cellular	26					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			skin(1)	1					Vitamin A(DB00162)	GGCAAAATCAATATCTGTTGG	0.428													0	0	0	0.049695	0	19	114										G	139181129	A	G	139181129	3	3	35	1	0	0	0	0	1	0	0	0	13156	101	4	5	339	5	RBP2	3	139181129	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	3093049	139181129	58841301	19	8723										
MLF1	4291	broad.mit.edu	37	chr3	158314703	158314703	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ccaaatggtgtcaaatatgaGaaactatatgcagaaattag	8	5	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr3:158314703G>C	uc003fcb.2	+	3	385	c.248G>C	c.(247-249)AGA>ACA	p.R83T	MLF1_uc003fbz.2_Missense_Mutation_p.R58T|MLF1_uc003fca.2_Missense_Mutation_p.R58T|MLF1_uc003fbx.2_Missense_Mutation_p.R73T|MLF1_uc003fcc.2_Missense_Mutation_p.R114T|MLF1_uc003fby.2_Missense_Mutation_p.R9T|MLF1_uc010hvx.2_Missense_Mutation_p.R58T	NM_022443	NP_071888	P58340	MLF1_HUMAN	myeloid leukemia factor 1 isoform 1	83	Interaction with COPS3.				cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding				0		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)			TCAAATATGAGAAACTATATG	0.299			T	NPM1	AML								0	0	0	0.132662	0	13	35										C	158314703	G	C	158314703	3	2	35	1	0	0	0	0	1	0	0	0	9614	942	33	1	258	1	MLF1	3	158314703	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	19133574	158314703	39707727	20	8724										
SLC2A2	6514	broad.mit.edu	37	chr3	170716012	170716012	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tggaaacacagagctacaatGaaattgcaggtccaattgct	9	8	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr3:170716012G>A	uc003fhe.1	-	10	1653	c.1344C>T	c.(1342-1344)TTC>TTT	p.F448F	SLC2A2_uc003fhf.1_Silent_p.F275F|SLC2A2_uc011bpu.1_Silent_p.F321F	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	448	Helical; Name=11; (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GAGCTACAATGAAATTGCAGG	0.458													0	0	0	0.132662	0	16	88										A	170716012	G	A	170716012	2	1	35	1	0	0	0	0	0	0	0	1	14544	1281	45	1		1	SLC2A2	3	170716012	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	12401309	170716012	27306418	21	8725										
SORBS2	8470	broad.mit.edu	37	chr4	186544867	186544867	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gcgttagactggcagcctcgCcggccccgagcgggggggcc	18	15	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr4:186544867C>A	uc003iyl.2	-	13	2562	c.1704G>T	c.(1702-1704)CGG>CGT	p.R568R	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Silent_p.R668R|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Silent_p.R472R|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Silent_p.R682R|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	568						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGCAGCCTCGCCGGCCCCGAG	0.592													1	0	0.00307968	0.038147	0.0031421	6	56										A	186544867	C	A	186544867	2	1	35	1	0	0	0	0	0	0	0	1	14928	726	26	4		4	SORBS2	4	186544867	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		186544867	4609409	22	8726										
IRX1	79192	broad.mit.edu	37	chr5	3600733	3600733	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tctctcgcagagagagacctCgtccccaggccagattcgcc	10	16	1	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:3600733C>T	uc003jde.2	+	3	1375	c.1323C>T	c.(1321-1323)CTC>CTT	p.L441L		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	441						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						AGAGAGACCTCGTCCCCAGGC	0.617													0	0	0	0.058154	0	10	141										T	3600733	C	T	3600733	2	4	35	1	0	0	0	0	0	0	0	1	7843	871	31	1		1	IRX1	5	3600733	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		3600733	177314527	23	8727										
TRIO	7204	broad.mit.edu	37	chr5	14359563	14359563	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acgaggcgcagtcgcagatgGaggagctcttccaggagcgc	16	11	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:14359563G>C	uc003jff.2	+	13	2320	c.2314G>C	c.(2314-2316)GAG>CAG	p.E772Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E723Q|TRIO_uc003jfh.1_Missense_Mutation_p.E421Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	772					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GTCGCAGATGGAGGAGCTCTT	0.617													0	0	0	0.058154	0	8	104										C	14359563	G	C	14359563	3	2	35	1	0	0	0	0	1	0	0	0	16549	1175	41	1	2364	1	TRIO	5	14359563	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	10758830	14359563	166555697	24	8728										
TRIM23	373	broad.mit.edu	37	chr5	64906836	64906836	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ccatatctaaaattgatgctCggatctgattagcttctggt	8	8	3	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:64906836C>A	uc003jty.2	-	5	766	c.680G>T	c.(679-681)CGA>CTA	p.R227L	TRIM23_uc003jtw.2_Missense_Mutation_p.R227L|TRIM23_uc003jtx.2_Missense_Mutation_p.R227L	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	227					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		AATTGATGCTCGGATCTGATT	0.333													1	0	0.00909568	0.150653	0.00921777	3	51										A	64906836	C	A	64906836	3	1	35	1	0	0	0	0	1	0	0	0	16494	884	31	3	1139	3	TRIM23	5	64906836	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	50547273	64906836	116008424	25	8729										
MAP1B	4131	broad.mit.edu	37	chr5	71493610	71493610	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gaagactttggccaagaaaaGaaaactgatgatgttgaagc	11	5	0	6			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:71493610G>C	uc003kbw.3	+	5	4669	c.4428G>C	c.(4426-4428)AAG>AAC	p.K1476N	MAP1B_uc010iyw.1_Missense_Mutation_p.K1493N|MAP1B_uc010iyx.1_Missense_Mutation_p.K1350N|MAP1B_uc010iyy.1_Missense_Mutation_p.K1350N	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1476						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCCAAGAAAAGAAAACTGATG	0.408													0	0	0	0.083992	0	24	79										C	71493610	G	C	71493610	3	2	35	1	0	0	0	0	1	0	0	0	9228	933	33	1	4446	1	MAP1B	5	71493610	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	6586774	71493610	109421650	26	8730										
ARSB	411	broad.mit.edu	37	chr5	78076390	78076390	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tctttcttcagggtcccgatCaatatcaaagagccagaggg	10	10	5	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:78076390C>T	uc003kfq.2	-	8	2718	c.1432G>A	c.(1432-1434)GAT>AAT	p.D478N		NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	478					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		GGGTCCCGATCAATATCAAAG	0.498													0	0	0	0.150653	0	4	80										T	78076390	C	T	78076390	3	4	35	1	0	0	0	0	1	0	0	0	988	826	29	1	173	1	ARSB	5	78076390	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	6582780	78076390	102838870	27	8731										
PAPD4	167153	broad.mit.edu	37	chr5	78964813	78964813	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gaatcaaaccttggggacctCttactgggctttcttaaata	8	9	3	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:78964813C>G	uc010jae.1	+	13	1588	c.1170C>G	c.(1168-1170)CTC>CTG	p.L390L	PAPD4_uc003kgb.2_Silent_p.L390L|PAPD4_uc010jaf.1_Silent_p.L390L|PAPD4_uc003kga.2_Silent_p.L386L|PAPD4_uc003kfz.2_Silent_p.L347L	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	390	PAP-associated.				histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		TTGGGGACCTCTTACTGGGCT	0.318													0	0	0	0.139131	0	64	197										G	78964813	C	G	78964813	2	3	35	1	0	0	0	0	0	0	0	1	11424	900	32	1		1	PAPD4	5	78964813	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	888423	78964813	101950447	28	8732										
CKMT2	1160	broad.mit.edu	37	chr5	80561982	80561982	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	agcttgttcagatagtcatcGatggagtcaattacctggtg	11	7	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:80561982G>A	uc003khc.3	+	11	1407	c.1165G>A	c.(1165-1167)GAT>AAT	p.D389N	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Missense_Mutation_p.D389N|CKMT2_uc003khd.3_Missense_Mutation_p.D389N|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	389	Phosphagen kinase C-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	GATAGTCATCGATGGAGTCAA	0.418													0	0	0	0.083992	0	26	253										A	80561982	G	A	80561982	3	1	35	1	0	0	0	0	1	0	0	0	3451	1058	37	1	1199	1	CKMT2	5	80561982	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	1597169	80561982	100353278	29	8733										
FER	2241	broad.mit.edu	37	chr5	108436173	108436173	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ttagtgaaattttcattagaCgctgctgctggtatgttgta	10	5	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:108436173C>T	uc003kop.1	+	17	2385	c.2001C>T	c.(1999-2001)GAC>GAT	p.D667D	FER_uc011cvg.1_Silent_p.D492D	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	667	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		TTTCATTAGACGCTGCTGCTG	0.348													0	0	0	0.038147	0	7	65										T	108436173	C	T	108436173	2	4	35	1	0	0	0	0	0	0	0	1	5813	535	19	2		2	FER	5	108436173	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	27874191	108436173	72479087	30	8734										
PCDHGA1	56114	broad.mit.edu	37	chr5	140710506	140710506	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cctagaagtggcagcttgatCaccgcgcgcaggatagaccg	13	12	1	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:140710506C>T	uc003lji.1	+	1	255	c.255C>T	c.(253-255)ATC>ATT	p.I85I	PCDHGA1_uc011dan.1_Silent_p.I85I	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	85	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCTTGATCACCGCGCGCA	0.547													0	0	0	0.083992	0	19	205										T	140710506	C	T	140710506	2	4	35	1	0	0	0	0	0	0	0	1	11550	816	29	1		1	PCDHGA1	5	140710506	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	32274333	140710506	40204754	31	8735										
PCDHGA4	56111	broad.mit.edu	37	chr5	140736823	140736823	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	agccttcagcagacccagacGactcgggcctcacactctat	8	16	3	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:140736823G>T	uc003ljq.1	+	1	2056	c.2056G>T	c.(2056-2058)GAC>TAC	p.D686Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGB2_uc003ljs.1_5'Flank|PCDHGA4_uc003ljp.1_Missense_Mutation_p.D686Y|PCDHGB2_uc011dar.1_5'Flank	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	686	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACCCAGACGACTCGGGCCT	0.617													1	0	1.45105e-14	0.175082	1.59933e-14	16	44										T	140736823	G	T	140736823	3	4	35	1	0	0	0	0	1	0	0	0	11556	1058	37	3	2058	3	PCDHGA4	5	140736823	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	26317	140736823	40178437	32	8736										
PCDHGB4	8641	broad.mit.edu	37	chr5	140769617	140769617	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tcctccagccccgcctcctgGagctgcttccagcctggtct	9	19	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr5:140769617G>C	uc003lkc.1	+	1	2166	c.2166G>C	c.(2164-2166)TGG>TGC	p.W722C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.W722C	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	722	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCCTCCTGGAGCTGCTTCC	0.572													0	0	0	0.139131	0	42	293										C	140769617	G	C	140769617	3	2	35	1	0	0	0	0	1	0	0	0	11565	1183	41	1	2168	1	PCDHGB4	5	140769617	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	32794	140769617	40145643	33	8737										
HLA-A	3105	broad.mit.edu	37	chr6	29910346	29910346	+	Frame_Shift_Del	DEL	C	C	-													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cgaggatggccgtcatggcgCcccgaaccctcctcctgcta							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:29910346delC	uc003nol.2	+	1	16	c.16delC	c.(16-18)CCCfs	p.P6fs	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Frame_Shift_Del_p.P6fs|HLA-A_uc003noo.2_Frame_Shift_Del_p.P6fs|HLA-A_uc010jrr.2_Frame_Shift_Del_p.P6fs|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_5'Flank|HLA-A_uc011dmc.1_5'Flank|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	6					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CGTCATGGCGCCCCGAACCCT	0.677									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)								12	115	---	---								-	29910346	C	-	29910346	7	5	35	1	0	1	0	1	0	0	0	0	7195	739	26	0	18	0	HLA-A	6	29910346	Frame_Shift_Del	DEL	C	TCGA-CU-A0YO-01A-11D-A10S-08		29910346	141204721	34	8738										
MDC1	9656	broad.mit.edu	37	chr6	30673687	30673687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	agctctgaggacaagggagcCtctggagcttcctgactccc	12	13	2	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:30673687C>T	uc003nrg.3	-	10	3713	c.3273G>A	c.(3271-3273)GAG>GAA	p.E1091E	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Silent_p.E698E	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1091	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ACAAGGGAGCCTCTGGAGCTT	0.527								Other_conserved_DNA_damage_response_genes					0	0	0	0.139131	0	57	378										T	30673687	C	T	30673687	2	4	35	1	0	0	0	0	0	0	0	1	9403	680	24	2		2	MDC1	6	30673687	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	763341	30673687	140441380	35	8739										
BAT1	7919	broad.mit.edu	37	chr6	31498940	31498940	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggtagccacaagaattcgtcGttgaaaatctttaaactgct	8	8	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:31498940G>A	uc003ntt.2	-	9	1643	c.1012C>T	c.(1012-1014)CGA>TGA	p.R338*	BAT1_uc003ntq.2_Nonsense_Mutation_p.R71*|BAT1_uc003ntr.2_Nonsense_Mutation_p.R145*|BAT1_uc003nts.2_Nonsense_Mutation_p.R338*|BAT1_uc011dnn.1_Nonsense_Mutation_p.R260*|BAT1_uc003ntu.2_Nonsense_Mutation_p.R338*|BAT1_uc003ntv.2_Nonsense_Mutation_p.R338*	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	338	Helicase C-terminal.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						AGAATTCGTCGTTGAAAATCT	0.418													0	0	0	0.175082	0	14	73										A	31498940	G	A	31498940	4	1	35	1	0	0	0	0	0	1	0	0	1318	1153	40	2	286	2	BAT1	6	31498940	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	825253	31498940	139616127	36	8740										
GLO1	2739	broad.mit.edu	37	chr6	38649846	38649846	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tcaaaccttttacaagcactGtatacatcaggaacagcaat	5	10	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:38649846G>T	uc003ooc.2	-	5	530	c.408C>A	c.(406-408)TAC>TAA	p.Y136*		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	136					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	TACAAGCACTGTATACATCAG	0.403													1	0	1.50039e-11	0.062417	1.62992e-11	19	122										T	38649846	G	T	38649846	4	4	35	1	0	0	0	0	0	1	0	0	6449	1372	48	4	154	4	GLO1	6	38649846	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	7150906	38649846	132465221	37	8741										
ROS1	6098	broad.mit.edu	37	chr6	117710590	117710590	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acagcaccgaaagctcctgcGggcggcctggcagagggtgc	16	13	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:117710590G>A	uc003pxp.1	-	12	1881	c.1682C>T	c.(1681-1683)CCG>CTG	p.P561L	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	561	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAGCTCCTGCGGGCGGCCTGG	0.557			T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.160694	0	18	145										A	117710590	G	A	117710590	3	1	35	1	0	0	0	0	1	0	0	0	13531	1116	39	2	5489	2	ROS1	6	117710590	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	79060744	117710590	53404477	38	8742										
THEMIS	387357	broad.mit.edu	37	chr6	128150707	128150707	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atggattcgttgagtcccacTtatttgaaaaatctgtaagg	9	6	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:128150707T>G	uc003qbi.2	-	4	942	c.623A>C	c.(622-624)AAG>ACG	p.K208T	THEMIS_uc010kfa.2_Missense_Mutation_p.K111T|THEMIS_uc011ebt.1_Missense_Mutation_p.K208T|THEMIS_uc010kfb.2_Missense_Mutation_p.K173T	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	208	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TGAGTCCCACTTATTTGAAAA	0.363													0	0	0	0.116897	0	28	107										G	128150707	T	G	128150707	3	3	35	1	0	0	0	0	1	0	0	0	15857	1609	56	5	1439	5	THEMIS	6	128150707	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	10440117	128150707	42964360	39	8743										
FUCA2	2519	broad.mit.edu	37	chr6	143825240	143825240	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atcctcaaggaagagcggatGaaaccattcaaaaagggaat	10	7	2	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:143825240G>A	uc003qjm.2	-	3	654	c.562C>T	c.(562-564)CAT>TAT	p.H188Y	FUCA2_uc003qjn.2_5'Flank	NM_032020	NP_114409	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma precursor	188					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		AAGAGCGGATGAAACCATTCA	0.443													0	0	0	0.062417	0	22	87										A	143825240	G	A	143825240	3	1	35	1	0	0	0	0	1	0	0	0	6095	1290	45	1	861	1	FUCA2	6	143825240	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	15674533	143825240	27289827	40	8744										
PLEKHG1	57480	broad.mit.edu	37	chr6	151116991	151116991	+	Splice_Site	SNP	G	G	C													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atttcttttgtttccttgcaGagtgaagagttccacattta							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:151116991G>C	uc003qny.1	+	6	895	c.583_splice	c.e6-1	p.S195_splice	PLEKHG1_uc011eel.1_Splice_Site_p.S235_splice|PLEKHG1_uc011eem.1_Splice_Site_p.S254_splice|PLEKHG1_uc003qnz.2_Splice_Site_p.S195_splice	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TTTCCTTGCAGAGTGAAGAGT	0.343													0	0	0	0.11911	0	14	133										C	151116991	G	C	151116991	5	2	35	1	0	0	0	0	0	0	1	0	12068	956	33	1	596	1	PLEKHG1	6	151116991	Splice_Site	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	7291751	151116991	19998076	41	8745	42	2								
PLEKHG1	57480	broad.mit.edu	37	chr6	151116998	151116998	+	Missense_Mutation	SNP	G	G	A													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ttgtttccttgcagagtgaaGagttccacatttatacccag							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:151116998G>A	uc003qny.1	+	6	901	c.589G>A	c.(589-591)GAG>AAG	p.E197K	PLEKHG1_uc011eel.1_Missense_Mutation_p.E237K|PLEKHG1_uc011eem.1_Missense_Mutation_p.E256K|PLEKHG1_uc003qnz.2_Missense_Mutation_p.E197K	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	197	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GCAGAGTGAAGAGTTCCACAT	0.358													0	0	0	0.132662	0	15	138										A	151116998	G	A	151116998	3	1	35	1	0	0	0	0	1	0	0	0	12068	943	33	1	603	1	PLEKHG1	6	151116998	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	7	151116998	19998069	42	8746	42	2								
SYNE1	23345	broad.mit.edu	37	chr6	152651857	152651857	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gtctttagccaaggcaacaaTtacattaaattgtcgaggca	8	8	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr6:152651857T>C	uc010kiw.2	-	78	14565	c.13963A>G	c.(13963-13965)ATT>GTT	p.I4655V	SYNE1_uc003qot.3_Missense_Mutation_p.I4584V|SYNE1_uc003qou.3_Missense_Mutation_p.I4655V|SYNE1_uc010kiz.2_Missense_Mutation_p.I410V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4655	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGGCAACAATTACATTAAAT	0.428										HNSCC(10;0.0054)			0	0	0	0.160694	0	17	117										C	152651857	T	C	152651857	3	2	35	1	0	0	0	0	1	0	0	0	15442	1493	52	5	12779	5	SYNE1	6	152651857	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	1534859	152651857	18463210	43	8747										
SUN1	23353	broad.mit.edu	37	chr7	897568	897568	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gacacgtgaagaccggctgtGagacagtggatgccgtacaa	14	9	0	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr7:897568G>A	uc011jvp.1	+	14	1577	c.1498G>A	c.(1498-1500)GAG>AAG	p.E500K	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.E417K|SUN1_uc011jvq.1_Missense_Mutation_p.E397K|SUN1_uc003sjg.2_Missense_Mutation_p.E405K|SUN1_uc011jvr.1_Missense_Mutation_p.E298K|SUN1_uc003sji.2_Missense_Mutation_p.E338K|SUN1_uc003sjk.2_Missense_Mutation_p.E139K	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	527	Perinuclear space.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GACCGGCTGTGAGACAGTGGA	0.468													0	0	0	0.139131	0	91	218										A	897568	G	A	897568	3	1	35	1	0	0	0	0	1	0	0	0	15388	1291	45	1	1731	1	SUN1	7	897568	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		897568	158241095	44	8748										
GIGYF1	64599	broad.mit.edu	37	chr7	100280314	100280315	+	Frame_Shift_Ins	INS	-	-	C													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gccccaggccgctgctgccgINScccccactcttgtctggccc							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr7:100280314_100280315insC	uc003uwg.1	-	20	3507_3508	c.2498_2499insG	c.(2497-2499)GGCfs	p.G833fs		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	833										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CGCTGCTGCCGCCCCCACTCTT	0.693																		7	45	---	---								C	100280315	-	C	100280314	7	5	35	1	0	1	1	0	0	0	0	0	6377	1074	38	0	628	0	GIGYF1	7	100280314	Frame_Shift_Ins	INS	-	TCGA-CU-A0YO-01A-11D-A10S-08	99382746	100280314	58858349	45	8749										
ACHE	43	broad.mit.edu	37	chr7	100489998	100489998	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gtatcgcatcagtcgctgggCgaagattttctcctctgccg	11	12	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr7:100489998C>T	uc003uxd.2	-	2	1666	c.1510G>A	c.(1510-1512)GCC>ACC	p.A504T	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Missense_Mutation_p.A504T|ACHE_uc003uxf.2_Missense_Mutation_p.A504T|ACHE_uc003uxg.2_Missense_Mutation_p.A504T|ACHE_uc003uxh.2_Missense_Mutation_p.A416T|ACHE_uc003uxi.2_Missense_Mutation_p.A504T	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	504					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	AGTCGCTGGGCGAAGATTTTC	0.627													0	0	0	0.132662	0	13	80										T	100489998	C	T	100489998	3	4	35	1	0	0	0	0	1	0	0	0	141	768	27	2	481	2	ACHE	7	100489998	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	209684	100489998	58648665	46	8750										
TAS2R16	50833	broad.mit.edu	37	chr7	122635518	122635518	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	attgatgcccactgtagacaGaagcgagagatgcccaggct	12	10	0	4			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr7:122635518G>A	uc003vkl.1	-	1	237	c.171C>T	c.(169-171)TTC>TTT	p.F57F		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	57	Helical; Name=2; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						ACTGTAGACAGAAGCGAGAGA	0.428													0	0	0	0.083992	0	25	73										A	122635518	G	A	122635518	2	1	35	1	0	0	0	0	0	0	0	1	15566	933	33	1		1	TAS2R16	7	122635518	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	22145520	122635518	36503145	47	8751										
CUL1	8454	broad.mit.edu	37	chr7	148484186	148484186	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acagtgcaagtgacgatgccGaagccagcatgatctccaag	11	11	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr7:148484186G>A	uc010lpg.2	+	13	1979	c.1453G>A	c.(1453-1455)GAA>AAA	p.E485K	CUL1_uc003wey.2_Missense_Mutation_p.E485K|CUL1_uc003wez.2_Missense_Mutation_p.E375K|CUL1_uc003wfa.2_Missense_Mutation_p.E146K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	485					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGACGATGCCGAAGCCAGCAT	0.398													0	0	0	0.134883	0	30	72										A	148484186	G	A	148484186	3	1	35	1	0	0	0	0	1	0	0	0	4054	1059	37	1	1499	1	CUL1	7	148484186	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	25848668	148484186	10654477	48	8752										
MTMR9	66036	broad.mit.edu	37	chr8	11172556	11172556	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gtggttttgaggccctgattGaaagagagtggctgcaggtg	17	5	0	4			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr8:11172556G>T	uc003wtm.2	+	7	1494	c.1096G>T	c.(1096-1098)GAA>TAA	p.E366*	MTMR9_uc010lrx.2_Nonsense_Mutation_p.E259*|MTMR9_uc011kxa.1_Nonsense_Mutation_p.E281*	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	366	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		GGCCCTGATTGAAAGAGAGTG	0.488													1	0	6.38683e-12	0.134883	6.98849e-12	25	125										T	11172556	G	T	11172556	4	4	35	1	0	0	0	0	0	1	0	0	9950	1291	45	3	1122	3	MTMR9	8	11172556	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		11172556	135191466	49	8753										
INTS9	55756	broad.mit.edu	37	chr8	28651378	28651378	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgttggccacaggggagatgAagtagagggggacgctggaa	19	5	0	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr8:28651378A>G	uc003xha.2	-	10	1282	c.983T>C	c.(982-984)TTC>TCC	p.F328S	INTS9_uc011lav.1_Missense_Mutation_p.F304S|INTS9_uc011law.1_Missense_Mutation_p.F307S|INTS9_uc011lax.1_Missense_Mutation_p.F221S|INTS9_uc010lvc.2_RNA|INTS9_uc003xhb.2_Missense_Mutation_p.F328S	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	328					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		AGGGGAGATGAAGTAGAGGGG	0.468													0	0	0	0.02938	0	7	110										G	28651378	A	G	28651378	3	3	35	1	0	0	0	0	1	0	0	0	7785	246	9	5	1025	5	INTS9	8	28651378	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	17478822	28651378	117712644	50	8754										
GSR	2936	broad.mit.edu	37	chr8	30537169	30537169	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tcatcacacccaagtccctgCatatggatcccaaccacctg	5	17	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr8:30537169C>T	uc003xih.1	-	13	1528	c.1437G>A	c.(1435-1437)ATG>ATA	p.M479I		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	479					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	CAAGTCCCTGCATATGGATCC	0.343													0	0	0	0.038147	0	8	89										T	30537169	C	T	30537169	3	4	35	1	0	0	0	0	1	0	0	0	6828	710	25	2	135	2	GSR	8	30537169	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	1885791	30537169	115826853	51	8755										
ANK1	286	broad.mit.edu	37	chr8	41581117	41581117	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gcaccatgatcacgttgcccCtgcgggaggcgatgtgcagt	14	12	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr8:41581117C>T	uc003xok.2	-	8	830	c.746G>A	c.(745-747)AGG>AAG	p.R249K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.R249K|ANK1_uc003xoj.2_Missense_Mutation_p.R249K|ANK1_uc003xol.2_Missense_Mutation_p.R249K|ANK1_uc003xom.2_Missense_Mutation_p.R282K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	249	ANK 7.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CACGTTGCCCCTGCGGGAGGC	0.637													0	0	0	0.150653	0	4	107										T	41581117	C	T	41581117	3	4	35	1	0	0	0	0	1	0	0	0	620	681	24	2	5393	2	ANK1	8	41581117	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	11043948	41581117	104782905	52	8756										
DNM1	1759	broad.mit.edu	37	chr9	130986561	130986561	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ttaccccagacatggcctttGagaccattgtgaaaaagcag	9	10	0	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr9:130986561G>C	uc011mau.1	+	10	1315	c.1228G>C	c.(1228-1230)GAG>CAG	p.E410Q	DNM1_uc010mxr.2_Intron|DNM1_uc011mat.1_Missense_Mutation_p.E410Q	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	410					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						CATGGCCTTTGAGACCATTGT	0.408													0	0	0	0.09319	0	9	115										C	130986561	G	C	130986561	3	2	35	1	0	0	0	0	1	0	0	0	4670	1291	45	1	1266	1	DNM1	9	130986561	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		130986561	10226870	53	8757										
COL5A1	1289	broad.mit.edu	37	chr9	137664657	137664657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gacaccctggcaaagaaggcCctccaggagagaaaggaggt	14	10	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr9:137664657C>T	uc004cfe.2	+	26	2690	c.2308C>T	c.(2308-2310)CCT>TCT	p.P770S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	770	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CAAAGAAGGCCCTCCAGGAGA	0.607													0	0	0	0.11911	0	11	131										T	137664657	C	T	137664657	3	4	35	1	0	0	0	0	1	0	0	0	3696	623	22	2	2410	2	COL5A1	9	137664657	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	6678096	137664657	3548774	54	8758										
ITGA8	8516	broad.mit.edu	37	chr10	15614236	15614236	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atcctgtggattgatattagGatttggttggcactgcagag	13	5	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr10:15614236G>A	uc001ioc.1	-	25	2611	c.2611C>T	c.(2611-2613)CCT>TCT	p.P871S	ITGA8_uc010qcb.1_Missense_Mutation_p.P856S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	871	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TTGATATTAGGATTTGGTTGG	0.413													0	0	0	0.076483	0	20	85										A	15614236	G	A	15614236	3	1	35	1	0	0	0	0	1	0	0	0	7882	1174	41	1	604	1	ITGA8	10	15614236	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		15614236	119920511	55	8759										
OR13A1	79290	broad.mit.edu	37	chr10	45799078	45799078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggtgtaatacatgcacaccaCggtgaggtgggaagagcagg	16	7	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr10:45799078C>T	uc001jcc.1	-	4	1102	c.793G>A	c.(793-795)GTG>ATG	p.V265M	OR13A1_uc001jcd.1_Missense_Mutation_p.V261M	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	265	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGCACACCACGGTGAGGTGG	0.572													0	0	0	0.086207	0	39	96										T	45799078	C	T	45799078	3	4	35	1	0	0	0	0	1	0	0	0	10933	536	19	2	197	2	OR13A1	10	45799078	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	30184842	45799078	89735669	56	8760										
ARHGAP22	58504	broad.mit.edu	37	chr10	49667753	49667753	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aacagtggcttctccccacaGtcgaaggaatcctgcaggtc	10	13	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr10:49667753G>A	uc001jgt.2	-	5	930	c.633C>T	c.(631-633)GAC>GAT	p.D211D	ARHGAP22_uc001jgs.2_Silent_p.D121D|ARHGAP22_uc001jgu.2_Silent_p.D227D|ARHGAP22_uc010qgl.1_Silent_p.D168D|ARHGAP22_uc010qgm.1_Silent_p.D217D|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	211	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						TCTCCCCACAGTCGAAGGAAT	0.617													0	0	0	0.160694	0	17	171										A	49667753	G	A	49667753	2	1	35	1	0	0	0	0	0	0	0	1	872	1020	36	2		2	ARHGAP22	10	49667753	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	3868675	49667753	85866994	57	8761										
MGEA5	10724	broad.mit.edu	37	chr10	103547231	103547231	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gagaagggaaattagcaaggAaagtttctggcagtacttcc	12	6	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr10:103547231A>G	uc001ktv.2	-	15	2947	c.2504T>C	c.(2503-2505)TTC>TCC	p.F835S	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.F782S|MGEA5_uc009xws.2_Missense_Mutation_p.F768S	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	835	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		ATTAGCAAGGAAAGTTTCTGG	0.383													0	0	0	0.038147	0	8	101										G	103547231	A	G	103547231	3	3	35	1	0	0	0	0	1	0	0	0	9555	246	9	5	254	5	MGEA5	10	103547231	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	53879478	103547231	31987516	58	8762										
CCKBR	887	broad.mit.edu	37	chr11	6291461	6291461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tagccacgtggctgctgtccGgactactcatggtgccctac	11	14	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:6291461G>A	uc001mcp.2	+	3	740	c.547G>A	c.(547-549)GGA>AGA	p.G183R	CCKBR_uc001mcq.2_Missense_Mutation_p.G111R|CCKBR_uc001mcr.2_Missense_Mutation_p.G183R|CCKBR_uc001mcs.2_Missense_Mutation_p.G183R|CCKBR_uc001mct.1_5'Flank	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	183	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GCTGCTGTCCGGACTACTCAT	0.667													0	0	0	0.146539	0	14	70										A	6291461	G	A	6291461	3	1	35	1	0	0	0	0	1	0	0	0	2881	1117	39	2	557	2	CCKBR	11	6291461	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		6291461	128715055	59	8763										
USH1C	10083	broad.mit.edu	37	chr11	17553040	17553040	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cagaggcagacggctgggttCattgatgaccagcttcaggt	14	9	2	4			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:17553040C>T	uc001mnf.2	-	3	263	c.154G>A	c.(154-156)GAA>AAA	p.E52K	USH1C_uc001mne.2_Missense_Mutation_p.E52K|USH1C_uc009yhb.2_Missense_Mutation_p.E52K|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.E16K	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	52					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CGGCTGGGTTCATTGATGACC	0.617													0	0	0	0.105934	0	9	46										T	17553040	C	T	17553040	3	4	35	1	0	0	0	0	1	0	0	0	17031	835	29	1	2723	1	USH1C	11	17553040	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	11261579	17553040	117453476	60	8764										
RAB3IL1	5866	broad.mit.edu	37	chr11	61675662	61675662	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cttgggcctcctcccctgcaGaggtctccaccagggctcct	10	18	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:61675662G>C	uc001nso.2	-	2	286	c.128C>G	c.(127-129)TCT>TGT	p.S43C	RAB3IL1_uc001nsp.2_Missense_Mutation_p.S90C	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	43							protein binding			skin(2)|central_nervous_system(1)	3						CTCCCCTGCAGAGGTCTCCAC	0.711													0	0	0	0.115264	0	3	11										C	61675662	G	C	61675662	3	2	35	1	0	0	0	0	1	0	0	0	12937	942	33	1	1056	1	RAB3IL1	11	61675662	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	44122622	61675662	73330854	61	8765										
MAP4K2	5871	broad.mit.edu	37	chr11	64557669	64557669	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggctcactcacccacagtctCgatggggaaatcaaaggtca	10	12	5	0	rs148398112		TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:64557669C>G	uc001obh.2	-	29	2331	c.2239G>C	c.(2239-2241)GAG>CAG	p.E747Q	MAP4K2_uc001obg.2_RNA|MAP4K2_uc001obi.2_Missense_Mutation_p.E739Q	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	747	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CCCACAGTCTCGATGGGGAAA	0.617													0	0	0	0.09319	0	12	79										G	64557669	C	G	64557669	3	3	35	1	0	0	0	0	1	0	0	0	9260	893	31	1	239	1	MAP4K2	11	64557669	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	2882007	64557669	70448847	62	8766										
ATG2A	23130	broad.mit.edu	37	chr11	64662776	64662776	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggtcacctctcgcactgtgtCgtaggccttggccacaccct	10	16	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:64662776C>T	uc001obx.2	-	40	5681	c.5566G>A	c.(5566-5568)GAC>AAC	p.D1856N	uc009ypx.2_5'Flank|ATG2A_uc001obw.2_Missense_Mutation_p.D621N	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1856							protein binding			ovary(1)|central_nervous_system(1)	2						CGCACTGTGTCGTAGGCCTTG	0.706													0	0	0	0.021553	0	4	98										T	64662776	C	T	64662776	3	4	35	1	0	0	0	0	1	0	0	0	1093	884	31	1	258	1	ATG2A	11	64662776	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	105107	64662776	70343740	63	8767										
SLC35F2	54733	broad.mit.edu	37	chr11	107677535	107677535	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cggcgatgaagtggatcactCtgtatcttgcatgaagaata	11	7	3	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:107677535C>T	uc001pjq.2	-	4	903	c.482G>A	c.(481-483)AGA>AAA	p.R161K	SLC35F2_uc010rvu.1_Missense_Mutation_p.R13K|SLC35F2_uc001pjs.2_Missense_Mutation_p.R161K	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	161					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		GTGGATCACTCTGTATCTTGC	0.458													0	0	0	0.160694	0	16	90										T	107677535	C	T	107677535	3	4	35	1	0	0	0	0	1	0	0	0	14589	913	32	1	662	1	SLC35F2	11	107677535	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	43014759	107677535	27328981	64	8768										
SDHD	6392	broad.mit.edu	37	chr11	111959637	111959637	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tggactagcgagagggttgtCagtgttttgctcctgggtct	15	7	2	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:111959637C>T	uc001pmz.2	+	3	277	c.216C>T	c.(214-216)GTC>GTT	p.V72V	TIMM8B_uc001pmx.2_5'Flank|TIMM8B_uc001pmy.2_5'Flank	NM_003002	NP_002993	O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D	72	Helical; (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	AGAGGGTTGTCAGTGTTTTGC	0.498			Mis|N|F|S			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				0	0	0	0.062417	0	22	63										T	111959637	C	T	111959637	2	4	35	1	0	0	0	0	0	0	0	1	13967	813	29	1		1	SDHD	11	111959637	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	4282102	111959637	23046879	65	8769										
APOA4	337	broad.mit.edu	37	chr11	116692360	116692360	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgggtgcgcagctggtccgcGtagggctccaggcgctgctg	18	12	0	0	rs145317065		TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:116692360G>T	uc001pps.1	-	3	518	c.414C>A	c.(412-414)TAC>TAA	p.Y138*		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GCTGGTCCGCGTagggctcca	0.358													1	0	0.000978159	0.080935	0.00100478	11	42										T	116692360	G	T	116692360	4	4	35	1	0	0	0	0	0	1	0	0	783	1140	40	4	780	4	APOA4	11	116692360	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	4732723	116692360	18314156	66	8770										
MLL	4297	broad.mit.edu	37	chr11	118375024	118375024	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cttggaagctcagctcagctCattggagtcaagccgcagag	12	11	4	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:118375024C>T	uc001pta.2	+	27	8431	c.8408C>T	c.(8407-8409)TCA>TTA	p.S2803L	MLL_uc001ptb.2_Missense_Mutation_p.S2806L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2803					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAGCTCAGCTCATTGGAGTCA	0.443			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.014758	0	5	165										T	118375024	C	T	118375024	3	4	35	1	0	0	0	0	1	0	0	0	9620	838	29	1	8514	1	MLL	11	118375024	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	1682664	118375024	16631492	67	8771										
ROBO4	54538	broad.mit.edu	37	chr11	124755027	124755027	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aggcatcccccttcccagccGctgggtgtggctgacctcca	11	17	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr11:124755027G>A	uc001qbg.2	-	17	3051	c.2911C>T	c.(2911-2913)CGG>TGG	p.R971W	ROBO4_uc010sas.1_Missense_Mutation_p.R826W	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	971					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTTCCCAGCCGCTGGGTGTGG	0.622													0	0	0	0.069288	0	17	81										A	124755027	G	A	124755027	3	1	35	1	0	0	0	0	1	0	0	0	13516	1086	38	2	120	2	ROBO4	11	124755027	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	6380003	124755027	10251489	68	8772										
GALNT8	26290	broad.mit.edu	37	chr12	4835834	4835834	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aagaagcacaaaacccaaatGaaactcttcccacactcaca	3	14	2	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr12:4835834G>C	uc001qne.1	+	2	440	c.348G>C	c.(346-348)ATG>ATC	p.M116I		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	116	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AAACCCAAATGAAACTCTTCC	0.498													0	0	0	0.115264	0	3	36										C	4835834	G	C	4835834	3	2	35	1	0	0	0	0	1	0	0	0	6219	1290	45	1	354	1	GALNT8	12	4835834	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		4835834	129016061	69	8773										
C12orf11	55726	broad.mit.edu	37	chr12	27077408	27077408	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgaacttcactggttaaaacCggggacaactacagaaaaac	8	9	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr12:27077408C>A	uc001rhk.3	-	7	1221	c.684G>T	c.(682-684)CCG>CCT	p.P228P	C12orf11_uc010sjk.1_Silent_p.P127P	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	228					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					TGGTTAAAACCGGGGACAACT	0.318													1	0	2.47511e-08	0.134883	2.63198e-08	28	104										A	27077408	C	A	27077408	2	1	35	1	0	0	0	0	0	0	0	1	1675	639	23	4		4	C12orf11	12	27077408	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	22241574	27077408	106774487	70	8774										
CYP27B1	1594	broad.mit.edu	37	chr12	58157882	58157882	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gtgcataggctttactcacaTttttggggataatatagtca	9	6	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr12:58157882T>G	uc001spz.1	-	7	1366	c.1214A>C	c.(1213-1215)AAT>ACT	p.N405T	CYP27B1_uc001sqa.1_Missense_Mutation_p.N170T	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	405					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	TTTACTCACATTTTTGGGGAT	0.458													0	0	0	0.175082	0	17	44										G	58157882	T	G	58157882	3	3	35	1	0	0	0	0	1	0	0	0	4159	1507	52	5	324	5	CYP27B1	12	58157882	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	31080474	58157882	75694013	71	8775										
KNTC1	9735	broad.mit.edu	37	chr12	123057784	123057784	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aagtttataagagtttacatGagagaacatgacttgcaaga	9	4	0	5			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr12:123057784G>C	uc001ucv.2	+	26	2398	c.2235G>C	c.(2233-2235)ATG>ATC	p.M745I	KNTC1_uc010taf.1_Missense_Mutation_p.M708I	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	745					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GAGTTTACATGAGAGAACATG	0.398													0	0	0	0.173368	0	33	157										C	123057784	G	C	123057784	3	2	35	1	0	0	0	0	1	0	0	0	8428	1290	45	1	2333	1	KNTC1	12	123057784	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	64899902	123057784	10794111	72	8776			1	28		2	2	23	G		8.954039e-05
KNTC1	9735	broad.mit.edu	37	chr12	123057806	123057806	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gagaacatgacttgcaagagGaggaacttctcttgctgtac	11	8	1	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr12:123057806G>A	uc001ucv.2	+	26	2420	c.2257G>A	c.(2257-2259)GAG>AAG	p.E753K	KNTC1_uc010taf.1_Missense_Mutation_p.E716K	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	753					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTTGCAAGAGGAGGAACTTCT	0.378													0	0	0	0.134883	0	28	153										A	123057806	G	A	123057806	3	1	35	1	0	0	0	0	1	0	0	0	8428	1175	41	1	2355	1	KNTC1	12	123057806	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	22	123057806	10794089	73	8777			1	28		2	2	23	G		8.954039e-05
DCLK1	9201	broad.mit.edu	37	chr13	36401843	36401843	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aatcagaagaacgatattggGatgcttcactcttcttaaaa	7	7	4	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr13:36401843G>C	uc001uvf.2	-	10	1569	c.1336C>G	c.(1336-1338)CCC>GCC	p.P446A	DCLK1_uc001uve.3_Missense_Mutation_p.P139A|DCLK1_uc010teh.1_Missense_Mutation_p.P139A|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	446	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ACGATATTGGGATGCTTCACT	0.388													0	0	0	0.132662	0	15	105										C	36401843	G	C	36401843	3	2	35	1	0	0	0	0	1	0	0	0	4291	1174	41	1	889	1	DCLK1	13	36401843	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		36401843	78768035	74	8778										
LPAR6	10161	broad.mit.edu	37	chr13	48985928	48985928	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ttaatgtaacaggtttggttAaagtttttagcaccatacta	7	5	0	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr13:48985928A>C	uc010acu.2	-	1	1726	c.632T>G	c.(631-633)TTA>TGA	p.L211*	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Nonsense_Mutation_p.L211*|LPAR6_uc001vcf.2_Nonsense_Mutation_p.L211*	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	211	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						AGGTTTGGTTAAAGTTTTTAG	0.264													0	0	0	0.069234	0	10	61										C	48985928	A	C	48985928	4	2	35	1	0	0	0	0	0	1	0	0	8909	372	13	5	406	5	LPAR6	13	48985928	Nonsense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	12584085	48985928	66183950	75	8779										
CIDEB	27141	broad.mit.edu	37	chr14	24776597	24776597	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tttggctagcagctcctggcGggtggcagctgtcaggcctt	15	11	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr14:24776597G>A	uc001won.2	-	2	290	c.166C>T	c.(166-168)CGC>TGC	p.R56C	CIDEB_uc001woo.2_Missense_Mutation_p.R56C|CIDEB_uc001wop.2_Missense_Mutation_p.R56C|LTB4R2_uc001woq.1_5'Flank|LTB4R2_uc010alo.2_5'Flank|LTB4R2_uc001wor.2_5'Flank	NM_014430	NP_055245	Q9UHD4	CIDEB_HUMAN	cell death-inducing DFFA-like effector b	56	CIDE-N.				apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis	cytosol					0				GBM - Glioblastoma multiforme(265;0.0181)		AGCTCCTGGCGGGTGGCAGCT	0.587													0	0	0	0.146539	0	15	114										A	24776597	G	A	24776597	3	1	35	1	0	0	0	0	1	0	0	0	3426	1116	39	2	509	2	CIDEB	14	24776597	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		24776597	82572943	76	8780										
PTGDR	5729	broad.mit.edu	37	chr14	52735281	52735281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgccgagccgcgcgcggacgGgagggaagcgtcccctcagc	17	15	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr14:52735281G>A	uc001wzq.2	+	1	851	c.749G>A	c.(748-750)GGG>GAG	p.G250E		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	250	Cytoplasmic (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CGCGCGGACGGGAGGGAAGCG	0.667													0	0	0	0.183431	0	36	148										A	52735281	G	A	52735281	3	1	35	1	0	0	0	0	1	0	0	0	12741	1232	43	2	751	2	PTGDR	14	52735281	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	27958684	52735281	54614259	77	8781										
GPHB5	122876	broad.mit.edu	37	chr14	63784372	63784372	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gcaactcacctcccaggtctCacagcgaccccagcaggcat	8	18	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr14:63784372C>T	uc010apu.2	-	1	192	c.192G>A	c.(190-192)GTG>GTA	p.V64V	GPHB5_uc001xgc.2_Silent_p.V54V	NM_145171	NP_660154	Q86YW7	GPHB5_HUMAN	glycoprotein beta 5	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						extracellular region	hormone activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00372)|all cancers(60;0.0226)|BRCA - Breast invasive adenocarcinoma(234;0.0978)		TCCCAGGTCTCACAGCGACCC	0.532													0	0	0	0.02938	0	6	50										T	63784372	C	T	63784372	2	4	35	1	0	0	0	0	0	0	0	1	6609	813	29	1		1	GPHB5	14	63784372	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	11049091	63784372	43565168	78	8782										
ACTN1	87	broad.mit.edu	37	chr14	69371375	69371375	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aggaaagcgcctttcaccttCggcatccagcatcttgggga	11	12	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr14:69371375C>T	uc001xkl.2	-	7	983	c.673G>A	c.(673-675)GAA>AAA	p.E225K	ACTN1_uc010ttb.1_Missense_Mutation_p.E160K|ACTN1_uc001xkm.2_Missense_Mutation_p.E225K|ACTN1_uc001xkn.2_Missense_Mutation_p.E225K|ACTN1_uc001xko.1_Missense_Mutation_p.E160K|ACTN1_uc010ttd.1_Missense_Mutation_p.E204K	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	225	CH 2.|Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CTTTCACCTTCGGCATCCAGC	0.567													0	0	0	0.047766	0	6	114										T	69371375	C	T	69371375	3	4	35	1	0	0	0	0	1	0	0	0	204	893	31	1	2135	1	ACTN1	14	69371375	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	5587003	69371375	37978165	79	8783										
INO80	54617	broad.mit.edu	37	chr15	41372084	41372084	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggcagctcgacgcacctcctTcatgcactggtgagcaagct	11	14	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr15:41372084T>A	uc001zni.2	-	9	1159	c.946A>T	c.(946-948)AAG>TAG	p.K316*	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	316	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.|DBINO.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						CGCACCTCCTTCATGCACTGG	0.527													0	0	0	0.144211	0	30	200										A	41372084	T	A	41372084	4	1	35	1	0	0	0	0	0	1	0	0	7746	1792	62	5	3836	5	INO80	15	41372084	Nonsense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08		41372084	61159308	80	8784										
SPG11	80208	broad.mit.edu	37	chr15	44876169	44876169	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aaggcgacatctggattataAaaatgaaaataccggcatac	8	7	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr15:44876169A>C	uc001ztx.2	-	30	5740	c.5709T>G	c.(5707-5709)TTT>TTG	p.F1903L	SPG11_uc010bdw.2_Missense_Mutation_p.F192L|SPG11_uc010ueh.1_Missense_Mutation_p.F1903L|SPG11_uc010uei.1_Missense_Mutation_p.F1903L|SPG11_uc001zty.1_Missense_Mutation_p.F632L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1903	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CTGGATTATAAAAATGAAAAT	0.473													0	0	0	0.160694	0	16	65										C	44876169	A	C	44876169	3	2	35	1	0	0	0	0	1	0	0	0	15040	11	1	5	1666	5	SPG11	15	44876169	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	3504085	44876169	57655223	81	8785			2	29		2	2	12	A		4.47712e-05
SPG11	80208	broad.mit.edu	37	chr15	44876180	44876180	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tggattataaaaatgaaaatAccggcatactctacttgctt	6	7	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr15:44876180A>C	uc001ztx.2	-	30	5729	c.5698T>G	c.(5698-5700)TAT>GAT	p.Y1900D	SPG11_uc010bdw.2_Missense_Mutation_p.Y189D|SPG11_uc010ueh.1_Missense_Mutation_p.Y1900D|SPG11_uc010uei.1_Missense_Mutation_p.Y1900D|SPG11_uc001zty.1_Missense_Mutation_p.Y629D	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1900	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AAATGAAAATACCGGCATACT	0.473													0	0	0	0.175082	0	17	73										C	44876180	A	C	44876180	3	2	35	1	0	0	0	0	1	0	0	0	15040	391	14	5	1677	5	SPG11	15	44876180	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	11	44876180	57655212	82	8786			2	29		2	2	12	A		4.47712e-05
CSNK1G1	53944	broad.mit.edu	37	chr15	64496768	64496768	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gtccagtcgcctgacatatcGaaggtaggttgccatctcct	10	12	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr15:64496768G>A	uc002anf.2	-	9	1351	c.871C>T	c.(871-873)CGA>TGA	p.R291*	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Nonsense_Mutation_p.R291*|CSNK1G1_uc002anh.1_Nonsense_Mutation_p.R291*|CSNK1G1_uc002anj.2_Nonsense_Mutation_p.R273*	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	291	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						CTGACATATCGAAGGTAGGTT	0.448													0	0	0	0.021553	0	4	148										A	64496768	G	A	64496768	4	1	35	1	0	0	0	0	0	1	0	0	3954	1066	37	1	413	1	CSNK1G1	15	64496768	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	19620588	64496768	38034624	83	8787										
CD276	80381	broad.mit.edu	37	chr15	73994784	73994784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aggaccagggcagcgcctatGccaaccgcacggccctcttc	11	17	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr15:73994784G>A	uc002avv.1	+	3	502	c.268G>A	c.(268-270)GCC>ACC	p.A90T	CD276_uc010bjd.1_5'UTR|CD276_uc002avu.1_Missense_Mutation_p.A90T|CD276_uc002avw.1_Missense_Mutation_p.A90T|CD276_uc010ulb.1_Missense_Mutation_p.A36T|CD276_uc002avx.2_5'Flank	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	90	Ig-like V-type 1.|Extracellular (Potential).				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						CAGCGCCTATGCCAACCGCAC	0.642													0	0	0	0.014758	0	5	60										A	73994784	G	A	73994784	3	1	35	1	0	0	0	0	1	0	0	0	2992	1319	46	2	274	2	CD276	15	73994784	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	9498016	73994784	28536608	84	8788										
AGBL1	123624	broad.mit.edu	37	chr15	87217600	87217600	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aatctgccagctgcagccatCagctcctggctcaagctgca	9	15	3	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr15:87217600C>T	uc002blz.1	+	22	3096	c.3016C>T	c.(3016-3018)CAG>TAG	p.Q1006*		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	1006					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CTGCAGCCATCAGCTCCTGGC	0.562													0	0	0	0.02938	0	7	24										T	87217600	C	T	87217600	4	4	35	1	0	0	0	0	0	1	0	0	375	827	29	1	3098	1	AGBL1	15	87217600	Nonsense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	13222816	87217600	15313792	85	8789										
MSLNL	401827	broad.mit.edu	37	chr16	823284	823284	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gaggtcgtcccgcagcgtggCggccgtgatgttgcctcaga	16	12	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:823284C>T	uc002cjz.1	-	10	1984	c.1984G>A	c.(1984-1986)GCC>ACC	p.A662T		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	311	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CGCAGCGTGGCGGCCGTGATG	0.652													0	0	0	0.146539	0	17	80										T	823284	C	T	823284	3	4	35	1	0	0	0	0	1	0	0	0	9882	768	27	2	1205	2	MSLNL	16	823284	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		823284	89531469	86	8790										
ZNF597	146434	broad.mit.edu	37	chr16	3486866	3486866	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aagcaagatttggtttctcaTtaaaatgtttatcacagtta	6	5	2	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:3486866T>G	uc002cvd.2	-	4	1017	c.833A>C	c.(832-834)AAT>ACT	p.N278T		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGGTTTCTCATTAAAATGTTT	0.443													0	0	0	0.080422	0	36	204										G	3486866	T	G	3486866	3	3	35	1	0	0	0	0	1	0	0	0	18024	1493	52	5	445	5	ZNF597	16	3486866	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	2663582	3486866	86867887	87	8791										
C16orf89	146556	broad.mit.edu	37	chr16	5110356	5110356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atgagtcctggggcccgaacGtggggtacaccaaggaggca	16	10	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:5110356G>A	uc010bud.2	-	3	642	c.554C>T	c.(553-555)ACG>ATG	p.T185M	ALG1_uc002cyj.2_Intron|C16orf89_uc002cyk.3_Missense_Mutation_p.T185M	NM_152459	NP_689672	Q6UX73	CP089_HUMAN	hypothetical protein LOC146556 isoform 1	147						extracellular region				ovary(1)|skin(1)	2						GGGCCCGAACGTGGGGTACAC	0.597													0	0	0	0.11911	0	14	69										A	5110356	G	A	5110356	3	1	35	1	0	0	0	0	1	0	0	0	1842	1145	40	2	927	2	C16orf89	16	5110356	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	1623490	5110356	85244397	88	8792										
UMOD	7369	broad.mit.edu	37	chr16	20352631	20352631	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atccgcacggtgaacatgccGgtcccgcccactctgatgtt	10	15	1	2	rs144461487		TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:20352631G>A	uc002dgz.2	-	7	1488	c.1359C>T	c.(1357-1359)ACC>ACT	p.T453T	UMOD_uc002dha.2_Silent_p.T453T|UMOD_uc002dhb.2_Silent_p.T486T	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	453	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						TGAACATGCCGGTCCCGCCCA	0.587													0	0	0	0.043863	0	17	79										A	20352631	G	A	20352631	2	1	35	1	0	0	0	0	0	0	0	1	16976	1103	39	2		2	UMOD	16	20352631	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	15242275	20352631	70002122	89	8793										
CDH8	1006	broad.mit.edu	37	chr16	61891104	61891104	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	actgtttccataaactgggtCatcagcgtcggtcgcagtga	11	10	2	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:61891104C>A	uc002eog.1	-	4	838	c.586G>T	c.(586-588)GAC>TAC	p.D196Y	CDH8_uc002eoh.2_5'UTR	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	196	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TAAACTGGGTCATCAGCGTCG	0.388													1	0	7.93312e-07	0.11911	8.31876e-07	14	55										A	61891104	C	A	61891104	3	1	35	1	0	0	0	0	1	0	0	0	3116	826	29	3	1849	3	CDH8	16	61891104	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	41538473	61891104	28463649	90	8794										
SF3B3	23450	broad.mit.edu	37	chr16	70575582	70575582	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ttcttcccagttacttatatCaaattgcacatcttggagat	5	9	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:70575582C>T	uc002ezf.2	+	9	1289	c.1078C>T	c.(1078-1080)CAA>TAA	p.Q360*		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	360					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TTACTTATATCAAATTGCACA	0.413													0	0	0	0.104719	0	36	214										T	70575582	C	T	70575582	4	4	35	1	0	0	0	0	0	1	0	0	14152	827	29	1	1108	1	SF3B3	16	70575582	Nonsense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	8684478	70575582	19779171	91	8795										
HYDIN	54768	broad.mit.edu	37	chr16	70884498	70884498	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	actttcttttccacattgcaGatcaaattaaagttcacatc	3	10	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr16:70884498G>A	uc002ezr.2	-	74	12629	c.12501C>T	c.(12499-12501)ATC>ATT	p.I4167I	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4168										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCACATTGCAGATCAAATTAA	0.448													0	0	0	0.069234	0	10	65										A	70884498	G	A	70884498	2	1	35	1	0	0	0	0	0	0	0	1	7467	932	33	1		1	HYDIN	16	70884498	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	308916	70884498	19470255	92	8796										
ARHGEF15	22899	broad.mit.edu	37	chr17	8216353	8216353	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aggaggtccccagggtccccCgtcgggcctccccgctgcgg	15	18	0	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:8216353C>T	uc002glc.2	+	3	836	c.715C>T	c.(715-717)CGT>TGT	p.R239C	ARHGEF15_uc002glb.1_3'UTR|ARHGEF15_uc002gld.2_Missense_Mutation_p.R239C|ARHGEF15_uc010vuw.1_Intron	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	239					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CAGGGTCCCCCGTCGGGCCTC	0.706													0	0	0	0.058154	0	10	170										T	8216353	C	T	8216353	3	4	35	1	0	0	0	0	1	0	0	0	898	652	23	2	721	2	ARHGEF15	17	8216353	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		8216353	72978857	93	8797										
MYH2	4620	broad.mit.edu	37	chr17	10448678	10448678	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ctcaccagtcagcatgaactGataggcgttgtcagagatgg	12	9	3	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:10448678G>A	uc010coi.2	-	5	618	c.490C>T	c.(490-492)CAG>TAG	p.Q164*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.Q164*|MYH2_uc010coj.2_Nonsense_Mutation_p.Q164*	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	164	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						AGCATGAACTGATAGGCGTTG	0.532													0	0	0	0.139131	0	43	283										A	10448678	G	A	10448678	4	1	35	1	0	0	0	0	0	1	0	0	10035	1299	45	1	5479	1	MYH2	17	10448678	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	2232325	10448678	70746532	94	8798										
MPRIP	23164	broad.mit.edu	37	chr17	17080692	17080692	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gcaacggaagcactgggggaGaagtcccctgacagtgccac	14	12	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:17080692G>A	uc002gqu.1	+	21	2981	c.2925G>A	c.(2923-2925)GAG>GAA	p.E975E	MPRIP_uc002gqv.1_Silent_p.E975E|MPRIP_uc002gqw.1_Silent_p.E730E|MPRIP_uc002gqx.1_Silent_p.E1204E|MPRIP_uc002gqy.1_Silent_p.E1204E|MPRIP_uc010cpl.1_Silent_p.E161E|MPRIP_uc010cpm.1_Silent_p.E161E	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	975	Potential.					cytoplasm|cytoskeleton	actin binding				0						CACTGGGGGAGAAGTCCCCTG	0.577													0	0	0	0.021553	0	6	90										A	17080692	G	A	17080692	2	1	35	1	0	0	0	0	0	0	0	1	9743	933	33	1		1	MPRIP	17	17080692	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	6632014	17080692	64114518	95	8799			3	30		2	2	22	G		8.547054e-05
MPRIP	23164	broad.mit.edu	37	chr17	17080713	17080713	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aagtcccctgacagtgccacGgtgtccggatatggtgcgtc	13	12	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:17080713G>A	uc002gqu.1	+	21	3002	c.2946G>A	c.(2944-2946)ACG>ACA	p.T982T	MPRIP_uc002gqv.1_Silent_p.T982T|MPRIP_uc002gqw.1_Silent_p.T737T|MPRIP_uc002gqx.1_Silent_p.T1211T|MPRIP_uc002gqy.1_Silent_p.T1211T|MPRIP_uc010cpl.1_Silent_p.T168T|MPRIP_uc010cpm.1_Silent_p.T168T	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	982						cytoplasm|cytoskeleton	actin binding				0						ACAGTGCCACGGTGTCCGGAT	0.587													0	0	0	0.021553	0	6	72										A	17080713	G	A	17080713	2	1	35	1	0	0	0	0	0	0	0	1	9743	1103	39	2		2	MPRIP	17	17080713	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	21	17080713	64114497	96	8800			3	30		2	2	22	G		8.547054e-05
KIAA0100	9703	broad.mit.edu	37	chr17	26971195	26971201	+	Frame_Shift_Del	DEL	CCACAAG	CCACAAG	-													0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ccacttggtggccaaccggaCcacaagccacctgcagaaaa							TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:26971195_26971201delCCACAAG	uc002hbu.2	-	2	172_178	c.73_79delCTTGTGG	c.(73-81)CTTGTGGTCfs	p.L25fs	KIAA0100_uc002hbv.2_Frame_Shift_Del_p.L25fs|KIAA0100_uc010crr.1_5'UTR	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	25_27						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					GCCAACCGGACCACAAGCCACCTGCAG	0.483											OREG0024280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						7	116	---	---								-	26971201	CCACAAG	-	26971195	7	5	35	1	0	1	0	1	0	0	0	0	8154	507	18	0	6780	0	KIAA0100	17	26971195	Frame_Shift_Del	DEL	CCACAAG	TCGA-CU-A0YO-01A-11D-A10S-08	9890482	26971195	54224015	97	8801										
ACE	1636	broad.mit.edu	37	chr17	61568636	61568636	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cctccctggggctgctgcccGtgcctcctgagttctggaac	12	16	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:61568636G>A	uc002jau.1	+	19	2828	c.2806G>A	c.(2806-2808)GTG>ATG	p.V936M	ACE_uc002jav.1_Missense_Mutation_p.V362M|ACE_uc010ddv.1_Missense_Mutation_p.V163M|ACE_uc010wpj.1_Missense_Mutation_p.V362M|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.V182M	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	936	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GCTGCTGCCCGTGCCTCCTGA	0.617													0	0	0	0.09319	0	13	101										A	61568636	G	A	61568636	3	1	35	1	0	0	0	0	1	0	0	0	136	1145	40	2	3083	2	ACE	17	61568636	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	34597441	61568636	19626574	98	8802										
CCDC40	55036	broad.mit.edu	37	chr17	78022498	78022498	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tggcagagagagtggagtccGaggggagtgacgaggaagca	20	5	0	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:78022498G>A	uc010dht.2	+	5	820	c.793G>A	c.(793-795)GAG>AAG	p.E265K	CCDC40_uc010wub.1_Missense_Mutation_p.E265K|CCDC40_uc002jxm.3_Missense_Mutation_p.E48K	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	265					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGTGGAGTCCGAGGGGAGTGA	0.612													0	0	0	0.038147	0	8	52										A	78022498	G	A	78022498	3	1	35	1	0	0	0	0	1	0	0	0	2812	1059	37	1	811	1	CCDC40	17	78022498	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	16453862	78022498	3172712	99	8803										
RPTOR	57521	broad.mit.edu	37	chr17	78704398	78704398	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cctctgtccatatatgacctGcagacgtggatgggcagccc	11	13	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr17:78704398G>A	uc002jyt.1	+	5	1351	c.546G>A	c.(544-546)CTG>CTA	p.L182L	RPTOR_uc002jys.2_Silent_p.L182L|RPTOR_uc010wuf.1_5'UTR|RPTOR_uc010wug.1_Silent_p.L182L	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	182					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						TATATGACCTGCAGACGTGGA	0.532													0	0	0	0.11911	0	13	94										A	78704398	G	A	78704398	2	1	35	1	0	0	0	0	0	0	0	1	13665	1306	46	2		2	RPTOR	17	78704398	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	681900	78704398	2490812	100	8804										
C18orf8	29919	broad.mit.edu	37	chr18	21110070	21110070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgcatcagttcctgcagtacCacgtcctcagcgactccaaa	7	15	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr18:21110070C>T	uc010xax.1	+	18	1694	c.1573C>T	c.(1573-1575)CAC>TAC	p.H525Y	C18orf8_uc002kul.2_RNA|C18orf8_uc010xay.1_Missense_Mutation_p.H149Y|NPC1_uc010dlu.1_Intron	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	525	Mic1.									ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCTGCAGTACCACGTCCTCAG	0.393													0	0	0	0.139131	0	46	421										T	21110070	C	T	21110070	3	4	35	1	0	0	0	0	1	0	0	0	1907	594	21	2	1639	2	C18orf8	18	21110070	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		21110070	56967178	101	8805										
HRH4	59340	broad.mit.edu	37	chr18	22048844	22048844	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tttggctcactactgactatCtgttatgtacagcatctgta	7	9	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr18:22048844C>G	uc002kvi.2	+	2	386	c.286C>G	c.(286-288)CTG>GTG	p.L96V	HRH4_uc010xbd.1_Intron|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	96	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TACTGACTATCTGTTATGTAC	0.408													0	0	0	0.049695	0	20	71										G	22048844	C	G	22048844	3	3	35	1	0	0	0	0	1	0	0	0	7358	912	32	1	292	1	HRH4	18	22048844	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	938774	22048844	56028404	102	8806										
ZNF521	25925	broad.mit.edu	37	chr18	22805418	22805418	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	caagtgtttttctaacaaaaTgatcgcatggaaggctttgc	9	7	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr18:22805418T>C	uc002kvk.2	-	4	2711	c.2464A>G	c.(2464-2466)ATT>GTT	p.I822V	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.I822V|ZNF521_uc002kvl.2_Missense_Mutation_p.I602V	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	822	C2H2-type 20.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCTAACAAAATGATCGCATGG	0.468			T	PAX5	ALL								0	0	0	0.175082	0	18	200										C	22805418	T	C	22805418	3	2	35	1	0	0	0	0	1	0	0	0	17962	1464	51	5	1491	5	ZNF521	18	22805418	Missense_Mutation	SNP	T	TCGA-CU-A0YO-01A-11D-A10S-08	756574	22805418	55271830	103	8807										
PALM	5064	broad.mit.edu	37	chr19	746578	746578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgggttaccagaacgtggagGatgaggccgagaccaagaag	16	7	0	4			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr19:746578G>A	uc002lpm.1	+	9	1122	c.928G>A	c.(928-930)GAT>AAT	p.D310N	PALM_uc002lpn.1_Missense_Mutation_p.D266N|PALM_uc010xfu.1_Missense_Mutation_p.D175N	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	310					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		GAACGTGGAGGATGAGGCCGA	0.657													0	0	0	0.080935	0	9	40										A	746578	G	A	746578	3	1	35	1	0	0	0	0	1	0	0	0	11408	1174	41	1	962	1	PALM	19	746578	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08		746578	58382405	104	8808										
SYCE2	256126	broad.mit.edu	37	chr19	13029049	13029049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tcctcacctagctggccctcCaccagcttcctcctcgcagt	6	20	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr19:13029049C>T	uc002mvr.2	-	2	133	c.118G>A	c.(118-120)GGA>AGA	p.G40R		NM_001105578	NP_001099048	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	40					cell division	central element					0						GCTGGCCCTCCACCAGCTTCC	0.597													0	0	0	0.09319	0	11	69										T	13029049	C	T	13029049	3	4	35	1	0	0	0	0	1	0	0	0	15426	603	21	2	558	2	SYCE2	19	13029049	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	12282471	13029049	46099934	105	8809										
MLL4	9757	broad.mit.edu	37	chr19	36211795	36211795	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acagtcccaccgtggcccccAaaagcaccaccttcctgaag	7	18	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr19:36211795A>G	uc010eei.2	+	3	1546	c.1546A>G	c.(1546-1548)AAA>GAA	p.K516E		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	516	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTGGCCCCCAAAAGCACCAC	0.622													0	0	0	0.014758	0	5	16										G	36211795	A	G	36211795	3	3	35	1	0	0	0	0	1	0	0	0	9623	131	5	5	1556	5	MLL4	19	36211795	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	23182746	36211795	22917188	106	8810										
PAF1	54623	broad.mit.edu	37	chr19	39876761	39876761	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggctccggctccgctggccaCccccattgctgccgctgtct	11	19	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr19:39876761C>G	uc002old.2	-	14	1641	c.1466G>C	c.(1465-1467)GGT>GCT	p.G489A	PAF1_uc002ole.1_Missense_Mutation_p.V418L	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	489					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CCGCTGGCCACCCCCATTGCT	0.617													0	0	0	0.09319	0	7	85										G	39876761	C	G	39876761	3	3	35	1	0	0	0	0	1	0	0	0	11383	507	18	4	133	4	PAF1	19	39876761	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	3664966	39876761	19252222	107	8811										
KLK1	3816	broad.mit.edu	37	chr19	51323464	51323464	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	caaacaggtgctccccacttCgggttcctcggtgggcaact	11	14	0	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr19:51323464C>G	uc002ptk.1	-	3	481	c.442G>C	c.(442-444)GAA>CAA	p.E148Q	KLK1_uc010ycg.1_RNA	NM_002257	NP_002248	P06870	KLK1_HUMAN	kallikrein 1 preproprotein	148	Peptidase S1.				proteolysis	nucleus	serine-type endopeptidase activity				0		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00399)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCCCACTTCGGGTTCCTCG	0.607													0	0	0	0.083992	0	14	106										G	51323464	C	G	51323464	3	3	35	1	0	0	0	0	1	0	0	0	8397	893	31	1	358	1	KLK1	19	51323464	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	11446703	51323464	7805519	108	8812										
FLRT3	23767	broad.mit.edu	37	chr20	14307451	14307451	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ggtgcagcagtcagggaattCcgcaccagggacagctctgt	14	11	2	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr20:14307451C>G	uc002wov.1	-	3	1169	c.702G>C	c.(700-702)CGG>CGC	p.R234R	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.R234R	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	234	Extracellular (Potential).|LRR 8.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCAGGGAATTCCGCACCAGGG	0.443													0	0	0	0.105934	0	12	99										G	14307451	C	G	14307451	2	3	35	1	0	0	0	0	0	0	0	1	5940	842	30	1		1	FLRT3	20	14307451	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		14307451	48718069	109	8813										
GINS1	9837	broad.mit.edu	37	chr20	25405846	25405846	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	tgatcatctctatgtttgcaGatggagtggtttaataatta	9	4	2	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr20:25405846G>A	uc002wuv.1	+	5	465	c.331_splice	c.e5-1	p.M111_splice	GINS1_uc010zte.1_Splice_Site	NM_021067	NP_066545	Q14691	PSF1_HUMAN	GINS complex subunit 1						DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				ovary(1)|central_nervous_system(1)	2						TATGTTTGCAGATGGAGTGGT	0.363													0	0	0	0.083992	0	24	89										A	25405846	G	A	25405846	5	1	35	1	0	0	0	0	0	0	1	0	6387	956	33	1	348	1	GINS1	20	25405846	Splice_Site	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	11098395	25405846	37619674	110	8814										
ZNF337	26152	broad.mit.edu	37	chr20	25666702	25666702	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gccctctgagcagggctcagCagcctccattccttctgggt	11	15	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr20:25666702C>T	uc002wva.2	-	2	606	c.84G>A	c.(82-84)CTG>CTA	p.L28L	ZNF337_uc010ztg.1_Silent_p.L28L|ZNF337_uc002wvb.2_Silent_p.L28L|ZNF337_uc002wvc.2_Silent_p.L28L	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGGGCTCAGCAGCCTCCATT	0.547													0	0	0	0.131918	0	40	268										T	25666702	C	T	25666702	2	4	35	1	0	0	0	0	0	0	0	1	17850	697	25	2		2	ZNF337	20	25666702	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	260856	25666702	37358818	111	8815										
BPIL1	80341	broad.mit.edu	37	chr20	31606901	31606901	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	acctgctgaacacctctgctCtgggccggctcatcccggag	11	16	3	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr20:31606901C>G	uc002wyj.2	+	10	1083	c.889C>G	c.(889-891)CTG>GTG	p.L297V		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	297						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						CACCTCTGCTCTGGGCCGGCT	0.567													0	0	0	0.134883	0	27	203										G	31606901	C	G	31606901	3	3	35	1	0	0	0	0	1	0	0	0	1491	912	32	1	923	1	BPIL1	20	31606901	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	5940199	31606901	31418619	112	8816										
SEMG1	6406	broad.mit.edu	37	chr20	43836572	43836572	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aacaacaacgtgagactaaaAattctcatcaaaataaaggg	6	7	2	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr20:43836572A>G	uc002xni.2	+	2	691	c.634A>G	c.(634-636)AAT>GAT	p.N212D	SEMG1_uc002xnj.2_Missense_Mutation_p.N212D|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Missense_Mutation_p.N212D	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	212	42 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TGAGACTAAAAATTCTCATCA	0.408													0	0	0	0.09319	0	12	137										G	43836572	A	G	43836572	3	3	35	1	0	0	0	0	1	0	0	0	14044	14	1	5	640	5	SEMG1	20	43836572	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	12229671	43836572	19188948	113	8817										
CDH22	64405	broad.mit.edu	37	chr20	44879792	44879792	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cgcgccgtcctgccgagctcCgggcgccgacggcgagggtg	18	16	0	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr20:44879792C>T	uc002xrm.2	-	1	543	c.142G>A	c.(142-144)GGA>AGA	p.G48R	CDH22_uc010ghk.1_Missense_Mutation_p.G48R	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	48	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				TGCCGAGCTCCGGGCGCCGAC	0.587													0	0	0	0.049695	0	14	15										T	44879792	C	T	44879792	3	4	35	1	0	0	0	0	1	0	0	0	3107	661	23	2	2388	2	CDH22	20	44879792	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	1043220	44879792	18145728	114	8818										
PDXK	8566	broad.mit.edu	37	chr21	45173597	45173597	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cacaagcaccccaataacctCaaggtcagccacacgcaccg	6	18	2	0	rs138572525		TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr21:45173597C>T	uc002zdm.3	+	9	954	c.756C>T	c.(754-756)CTC>CTT	p.L252L	PDXK_uc010gpj.2_Silent_p.L252L|PDXK_uc002zdn.3_Silent_p.L224L|PDXK_uc002zdq.3_Silent_p.L179L	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	252					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCAATAACCTCAAGGTCAGCC	0.622													0	0	0	0.105934	0	14	116										T	45173597	C	T	45173597	2	4	35	1	0	0	0	0	0	0	0	1	11697	813	29	1		1	PDXK	21	45173597	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		45173597	2956298	115	8819										
LSS	4047	broad.mit.edu	37	chr21	47627356	47627356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ccttaccacagccacagcatCgcagagccgttctctgggga	10	15	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr21:47627356C>T	uc002zij.2	-	15	1532	c.1453G>A	c.(1453-1455)GAT>AAT	p.D485N	LSS_uc011afv.1_Missense_Mutation_p.D474N|LSS_uc002zil.2_Missense_Mutation_p.D485N|LSS_uc002zik.2_Missense_Mutation_p.D405N	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	485	PFTB 2.				cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GCCACAGCATCGCAGAGCCGT	0.612													0	0	0	0.058154	0	10	17										T	47627356	C	T	47627356	3	4	35	1	0	0	0	0	1	0	0	0	9065	884	31	1	777	1	LSS	21	47627356	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	2453759	47627356	502539	116	8820										
C22orf29	79680	broad.mit.edu	37	chr22	19839452	19839452	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aagaagcggtccagtagccaCggggagccatcaaaggtgcc	14	11	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr22:19839452C>T	uc002zqg.2	-	2	932	c.333G>A	c.(331-333)CCG>CCA	p.P111P	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Silent_p.P111P|C22orf29_uc002zqi.2_Silent_p.P111P|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	111											0	Colorectal(54;0.0993)					CCAGTAGCCACGGGGAGCCAT	0.607													0	0	0	0.055883	0	18	133										T	19839452	C	T	19839452	2	4	35	1	0	0	0	0	0	0	0	1	2141	523	19	2		2	C22orf29	22	19839452	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		19839452	31465114	117	8821										
ASPHD2	57168	broad.mit.edu	37	chr22	26839131	26839131	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	atccaaacgtcgcagcggccGaacggcaggctcttgatttc	11	13	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr22:26839131G>A	uc003acg.2	+	4	1466	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	357	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1						CGCAGCGGCCGAACGGCAGGC	0.607													0	0	0	0.139131	0	64	303										A	26839131	G	A	26839131	3	1	35	1	0	0	0	0	1	0	0	0	1055	1059	37	1	1079	1	ASPHD2	22	26839131	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	6999679	26839131	24465435	118	8822										
LARGE	9215	broad.mit.edu	37	chr22	34157439	34157439	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cgaggcagccaagaatttccGtctccccctgcagattccca	8	16	1	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr22:34157439G>A	uc003and.3	-	3	604	c.25C>T	c.(25-27)CGG>TGG	p.R9W	LARGE_uc003ane.3_Missense_Mutation_p.R9W|LARGE_uc010gwp.2_Missense_Mutation_p.R9W|LARGE_uc011ame.1_Intron|LARGE_uc011amf.1_Missense_Mutation_p.R9W	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	9	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				AAGAATTTCCGTCTCCCCCTG	0.532													0	0	0	0.02938	0	7	163										A	34157439	G	A	34157439	3	1	35	1	0	0	0	0	1	0	0	0	8627	1144	40	2	2301	2	LARGE	22	34157439	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	7318308	34157439	17147127	119	8823										
MICALL1	85377	broad.mit.edu	37	chr22	38329085	38329085	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gagcagcgccaggctgatgtCgagtatgagctccggtgcct	15	11	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr22:38329085C>G	uc003aui.2	+	13	2358	c.2274C>G	c.(2272-2274)GTC>GTG	p.V758V		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	758						cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					AGGCTGATGTCGAGTATGAGC	0.632													0	0	0	0.09319	0	12	91										G	38329085	C	G	38329085	2	3	35	1	0	0	0	0	0	0	0	1	9573	871	31	1		1	MICALL1	22	38329085	Silent	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	4171646	38329085	12975481	120	8824										
KLHDC7B	113730	broad.mit.edu	37	chr22	50987674	50987674	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	caactacctgtttctggcggGgggcatccgtggctccggtg	15	12	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr22:50987674G>A	uc003bmi.2	+	1	1213	c.1079G>A	c.(1078-1080)GGG>GAG	p.G360E		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	360	Kelch 2.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TTTCTGGCGGGGGGCATCCGT	0.667													0	0	0	0.144211	0	27	123										A	50987674	G	A	50987674	3	1	35	1	0	0	0	0	1	0	0	0	8361	1232	43	2	1081	2	KLHDC7B	22	50987674	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	12658589	50987674	316892	121	8825										
CPT1B	1375	broad.mit.edu	37	chr22	51009598	51009598	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gacacttactgtgtgggaccCctccatcatggcctgcacaa	9	14	1	0			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chr22:51009598C>T	uc003bmk.3	-	14	2026	c.1864G>A	c.(1864-1866)GGG>AGG	p.G622R	CPT1B_uc003bml.2_Missense_Mutation_p.G622R|CPT1B_uc003bmm.2_Missense_Mutation_p.G622R|CPT1B_uc003bmo.2_Missense_Mutation_p.G622R|CPT1B_uc011asa.1_Missense_Mutation_p.G588R|CPT1B_uc003bmn.2_Missense_Mutation_p.G622R|CPT1B_uc011asb.1_Missense_Mutation_p.G541R|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.G417R|uc003bmr.1_RNA	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	622	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		GTGTGGGACCCCTCCATCATG	0.612													0	0	0	0.049695	0	19	109										T	51009598	C	T	51009598	3	4	35	1	0	0	0	0	1	0	0	0	3832	623	22	2	474	2	CPT1B	22	51009598	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08	21924	51009598	294968	122	8826										
DDX53	168400	broad.mit.edu	37	chrX	23019072	23019072	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	aaaggaatgggcctgggatgCtagtccttacacccactaga	11	10	0	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chrX:23019072C>A	uc004daj.2	+	1	986	c.898C>A	c.(898-900)CTA>ATA	p.L300I		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	300	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						GCCTGGGATGCTAGTCCTTAC	0.418													1	0	3.59834e-05	0.021553	3.74723e-05	4	64										A	23019072	C	A	23019072	3	1	35	1	0	0	0	0	1	0	0	0	4371	796	28	4	900	4	DDX53	23	23019072	Missense_Mutation	SNP	C	TCGA-CU-A0YO-01A-11D-A10S-08		23019072	132251488	123	8827										
DDX53	168400	broad.mit.edu	37	chrX	23019219	23019219	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	ttagcaaaggtgtagatatcAttattgcaactcctgggagg	11	6	1	1			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chrX:23019219A>T	uc004daj.2	+	1	1133	c.1045A>T	c.(1045-1047)ATT>TTT	p.I349F		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	349	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						TGTAGATATCATTATTGCAAC	0.353													0	0	0	0.021553	0	4	84										T	23019219	A	T	23019219	3	4	35	1	0	0	0	0	1	0	0	0	4371	217	8	5	1047	5	DDX53	23	23019219	Missense_Mutation	SNP	A	TCGA-CU-A0YO-01A-11D-A10S-08	147	23019219	132251341	124	8828										
MED12	9968	broad.mit.edu	37	chrX	70339981	70339981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	cctactatgcagcaatctctGagaccaaggttaagaagaga	9	9	1	3			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chrX:70339981G>C	uc004dyy.2	+	4	713	c.514G>C	c.(514-516)GAG>CAG	p.E172Q	MED12_uc011mpq.1_Missense_Mutation_p.E172Q|MED12_uc004dyz.2_Missense_Mutation_p.E172Q|MED12_uc004dza.2_Missense_Mutation_p.E19Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	172					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AGCAATCTCTGAGACCAAGGT	0.488													0	0	0	0.125774	0	27	53										C	70339981	G	C	70339981	3	2	35	1	0	0	0	0	1	0	0	0	9428	1291	45	1	528	1	MED12	23	70339981	Missense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	47320762	70339981	84930579	125	8829										
PHF6	84295	broad.mit.edu	37	chrX	133512098	133512098	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gtcttggtggattttctattGaagatgtccaaaaggaaatt	10	4	2	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chrX:133512098G>T	uc004exj.2	+	3	404	c.202G>T	c.(202-204)GAA>TAA	p.E68*	PHF6_uc004exk.2_Nonsense_Mutation_p.E68*|PHF6_uc011mvk.1_Intron|PHF6_uc004exh.2_Nonsense_Mutation_p.E68*|PHF6_uc010nrr.2_Nonsense_Mutation_p.E68*|PHF6_uc004exi.2_Nonsense_Mutation_p.E68*	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ATTTTCTATTGAAGATGTCCA	0.299													1	0	7.41877e-09	0.062417	7.94565e-09	17	48										T	133512098	G	T	133512098	4	4	35	1	0	0	0	0	0	1	0	0	11838	1291	45	3	208	3	PHF6	23	133512098	Nonsense_Mutation	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	63172117	133512098	21758462	126	8830										
MAGEA1	4100	broad.mit.edu	37	chrX	152482885	152482885	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277777777777778	35	2.32510520729818e-09	2.99679487179487	4.45238095238095	2.56011904761905	0.0207494859368467	0.0599429593731127	23	gcagtgggcacctcctccagGgtgcccaggaccagaggaga	15	13	0	2			TCGA-CU-A0YO-01A-11D-A10S-08	TCGA-CU-A0YO-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e80278f9-2059-4e98-92b2-3e9868fc5818	1a1db5dc-c338-4de0-aea2-20e78cb094b3	g.chrX:152482885G>A	uc004fhf.2	-	3	346	c.126C>T	c.(124-126)ACC>ACT	p.T42T		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	42						cytoplasm|plasma membrane				central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTCCAGGGTGCCCAGGA	0.627													0	0	0	0.074837	0	39	109										A	152482885	G	A	152482885	2	1	35	1	0	0	0	0	0	0	0	1	9163	1219	43	2		2	MAGEA1	23	152482885	Silent	SNP	G	TCGA-CU-A0YO-01A-11D-A10S-08	18970787	152482885	2787675	127	8831										
SAMD11	148398	broad.mit.edu	37	chr1	871255	871255	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aattccagagaggcagcctgGagattggcctgcgacccgcc	13	13	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:871255G>A	uc001abw.1	+	5	489	c.409G>A	c.(409-411)GAG>AAG	p.E137K	SAMD11_uc001abv.1_Missense_Mutation_p.E137K|SAMD11_uc001abx.1_Missense_Mutation_p.E16K	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	137						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		AGGCAGCCTGGAGATTGGCCT	0.677													0	0	0	0.013726	0	32	33										A	871255	G	A	871255	3	1	36	1	0	0	0	0	1	0	0	0	13816	1175	41	1	423	1	SAMD11	1	871255	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08		871255	248379366	1	8832										
TNFRSF4	7293	broad.mit.edu	37	chr1	1148065	1148065	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tcgcctggggagaagtgcccTggagggcagggggcacagtc	19	10	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:1148065T>C	uc001ade.2	-	4	395	c.390A>G	c.(388-390)CCA>CCG	p.P130P	TNFRSF4_uc001adf.2_Silent_p.P134P	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	130	TNFR-Cys 4.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGAAGTGCCCTGGAGGGCAGG	0.557													0	0	0	0.008291	0	8	9										C	1148065	T	C	1148065	2	2	36	1	0	0	0	0	0	0	0	1	16294	1567	55	5		5	TNFRSF4	1	1148065	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	276810	1148065	248102556	2	8833										
CDK11B	984	broad.mit.edu	37	chr1	1572863	1572863	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gatcttgtccatgttgctgcCcaccacaatctcctgcaggg	9	14	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:1572863C>A	uc001agv.1	-	18	1588	c.1477G>T	c.(1477-1479)GGC>TGC	p.G493C	CDK11B_uc009vkj.2_Missense_Mutation_p.G150C|CDK11B_uc001ags.1_Missense_Mutation_p.G351C|CDK11B_uc001agt.1_Missense_Mutation_p.G276C|CDK11B_uc001aha.1_Missense_Mutation_p.G459C|CDK11B_uc001agw.1_Missense_Mutation_p.G448C|CDK11B_uc001agy.1_Missense_Mutation_p.G491C|CDK11B_uc001agx.1_Missense_Mutation_p.G482C|CDK11B_uc001agz.1_Missense_Mutation_p.G237C	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	506	Protein kinase.		G -> S.		apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						ATGTTGCTGCCCACCACAATC	0.602													1	0	3.59834e-05	0.001168	3.73876e-05	5	44										A	1572863	C	A	1572863	3	1	36	1	0	0	0	0	1	0	0	0	3127	623	22	4	899	4	CDK11B	1	1572863	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	424798	1572863	247677758	3	8834										
TNFRSF9	3604	broad.mit.edu	37	chr1	7993258	7993258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caggagtttctttctgccccGtttaacaacagagaaacgga	9	10	2	1	rs143524950		TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:7993258G>A	uc001aot.2	-	7	771	c.643C>T	c.(643-645)CGG>TGG	p.R215W		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	215	Cytoplasmic (Potential).|Interaction with LRR-1.				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCTGCCCCGTTTAACAACA	0.428													0	0	0	0.015359	0	34	43										A	7993258	G	A	7993258	3	1	36	1	0	0	0	0	1	0	0	0	16297	1144	40	2	132	2	TNFRSF9	1	7993258	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	6420395	7993258	241257363	4	8835										
RERE	473	broad.mit.edu	37	chr1	8601355	8601355	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agcagcaaatatgtcagaaaAatgggagatgttacacttcc	9	7	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:8601355A>C	uc001ape.2	-	8	1558	c.748T>G	c.(748-750)TTT>GTT	p.F250V	RERE_uc001apf.2_Missense_Mutation_p.F250V|RERE_uc001aph.1_Missense_Mutation_p.F250V	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	250	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		ATGTCAGAAAAATGGGAGATG	0.398													0	0	0	0.01441	0	60	64										C	8601355	A	C	8601355	3	2	36	1	0	0	0	0	1	0	0	0	13231	14	1	5	4020	5	RERE	1	8601355	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	608097	8601355	240649266	5	8836										
MASP2	10747	broad.mit.edu	37	chr1	11097837	11097837	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acaggtgaaacgtggccattAggtggcgccatcggataagg	15	8	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:11097837A>G	uc001aru.2	-	7	942	c.921T>C	c.(919-921)CCT>CCC	p.P307P		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	307	Sushi 1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CGTGGCCATTAGGTGGCGCCA	0.507											OREG0013096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01892	0	25	130										G	11097837	A	G	11097837	2	3	36	1	0	0	0	0	0	0	0	1	9323	407	15	5		5	MASP2	1	11097837	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	2496482	11097837	238152784	6	8837										
EXOSC10	5394	broad.mit.edu	37	chr1	11141199	11141200	+	Frame_Shift_Ins	INS	-	-	C													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gctgcaccggctgcccgttgINSccgcgctcccacatctccag							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:11141199_11141200insC	uc001asa.2	-	11	1426_1427	c.1376_1377insG	c.(1375-1377)GGCfs	p.G459fs	EXOSC10_uc001asb.2_Frame_Shift_Ins_p.G459fs|EXOSC10_uc009vmy.1_Frame_Shift_Ins_p.G459fs	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	459					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		GCTGCCCGTTGCCGCGCTCCCA	0.604																		20	102	---	---								C	11141200	-	C	11141199	7	5	36	1	0	1	1	0	0	0	0	0	5314	1306	46	0	1340	0	EXOSC10	1	11141199	Frame_Shift_Ins	INS	-	TCGA-CU-A0YR-01A-12D-A10S-08	43362	11141199	238109422	7	8838										
PRAMEF12	390999	broad.mit.edu	37	chr1	12835714	12835714	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aacttcaagtgttggacttgCggaatgtggatgagaacttc	12	6	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:12835714C>T	uc001aui.2	+	2	343	c.316C>T	c.(316-318)CGG>TGG	p.R106W		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	106										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTTGGACTTGCGGAATGTGGA	0.512													0	0	0	0.01441	0	51	333										T	12835714	C	T	12835714	3	4	36	1	0	0	0	0	1	0	0	0	12428	759	27	2	322	2	PRAMEF12	1	12835714	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	1694515	12835714	236414907	8	8839										
CAPZB	832	broad.mit.edu	37	chr1	19670914	19670914	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tcgttcagcgtacttctgatTttattttccatgtcctggaa	7	9	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:19670914T>C	uc010ocz.1	-	8	1184	c.756A>G	c.(754-756)AAA>AAG	p.K252K	CAPZB_uc001bce.2_Silent_p.K223K|CAPZB_uc009vpk.2_Intron|CAPZB_uc001bcd.2_Silent_p.K211K	NM_004930	NP_004921	P47756	CAPZB_HUMAN	F-actin capping protein beta subunit	223					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding				0		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		TACTTCTGATTTTATTTTCCA	0.438											OREG0013171	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	31	112										C	19670914	T	C	19670914	2	2	36	1	0	0	0	0	0	0	0	1	2643	1838	64	5		5	CAPZB	1	19670914	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	6835200	19670914	229579707	9	8840										
BMP8B	656	broad.mit.edu	37	chr1	40228856	40228856	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtaataggccgagtagccttGgggagcgatgacccagtcct	14	10	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:40228856G>A	uc001cdz.1	-	6	1343	c.967C>T	c.(967-969)CAA>TAA	p.Q323*	PPIE_uc001cdv.2_Intron|PPIE_uc001cdw.2_Intron	NM_001720	NP_001711	P34820	BMP8B_HUMAN	bone morphogenetic protein 8B preproprotein	323					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity				0	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAGTAGCCTTGGGGAGCGATG	0.622													0	0	0	0.007835	0	39	142										A	40228856	G	A	40228856	4	1	36	1	0	0	0	0	0	1	0	0	1467	1357	47	2	249	2	BMP8B	1	40228856	Nonsense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	20557942	40228856	209021765	10	8841										
FGGY	55277	broad.mit.edu	37	chr1	59787249	59787249	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtggagaacagaaaccagagAggtactatgtgggtgtggac	16	5	0	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:59787249A>T	uc001czi.3	+	2	240	c.28A>T	c.(28-30)AGG>TGG	p.R10W	FGGY_uc001czg.2_5'UTR|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.R10W|FGGY_uc001czj.3_Missense_Mutation_p.R10W|FGGY_uc001czk.3_Intron|FGGY_uc001czl.3_Missense_Mutation_p.R10W	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	10					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					GAAACCAGAGAGGTACTATGT	0.493													0	0	0	0.006214	0	7	24										T	59787249	A	T	59787249	3	4	36	1	0	0	0	0	1	0	0	0	5871	295	11	5	30	5	FGGY	1	59787249	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	19558393	59787249	189463372	11	8842										
EFCAB7	84455	broad.mit.edu	37	chr1	64027423	64027423	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gaactaacaagacaaggattTatggatttgaatctaatgga	9	4	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:64027423T>C	uc001dbf.2	+	11	1686	c.1392T>C	c.(1390-1392)TTT>TTC	p.F464F		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	464							calcium ion binding				0						GACAAGGATTTATGGATTTGA	0.308													0	0	0	0.001984	0	5	53										C	64027423	T	C	64027423	2	2	36	1	0	0	0	0	0	0	0	1	4940	1751	61	5		5	EFCAB7	1	64027423	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	4240174	64027423	185223198	12	8843										
BCL10	8915	broad.mit.edu	37	chr1	85741980	85741980	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gcacagctgcgttactcacgTccttcttcacttcagtgagg	9	13	4	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:85741980T>A	uc001dkz.2	-	2	761	c.56A>T	c.(55-57)GAC>GTC	p.D19V	uc001dla.1_5'Flank	NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	19	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		GTTACTCACGTCCTTCTTCAC	0.682			T	IGH@	MALT 								0	0	0	0.010818	0	28	99										A	85741980	T	A	85741980	3	1	36	1	0	0	0	0	1	0	0	0	1362	1681	58	5	657	5	BCL10	1	85741980	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	21714557	85741980	163508641	13	8844										
MOV10	4343	broad.mit.edu	37	chr1	113217556	113217556	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgcccagtaagttcagctgcCggcagctccgggaggcgggc	16	13	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:113217556C>G	uc001eck.2	+	2	292	c.22C>G	c.(22-24)CGG>GGG	p.R8G	MOV10_uc001ecl.2_Missense_Mutation_p.R8G|MOV10_uc001ecn.2_Missense_Mutation_p.R8G|MOV10_uc001ecm.2_5'UTR|MOV10_uc009wgj.1_5'UTR	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	8					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GTTCAGCTGCCGGCAGCTCCG	0.637													0	0	0	0.00632	0	20	69										G	113217556	C	G	113217556	3	3	36	1	0	0	0	0	1	0	0	0	9718	643	23	4	24	4	MOV10	1	113217556	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	27475576	113217556	136033065	14	8845										
NES	10763	broad.mit.edu	37	chr1	156639511	156639511	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagaaggctcagcactgtccTgggactccgtttccagggca	12	13	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:156639511T>C	uc001fpq.2	-	4	4602	c.4469A>G	c.(4468-4470)CAG>CGG	p.Q1490R		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1490	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGCACTGTCCTGGGACTCCGT	0.587													0	0	0	0.007413	0	20	81										C	156639511	T	C	156639511	3	2	36	1	0	0	0	0	1	0	0	0	10337	1580	55	5	400	5	NES	1	156639511	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	43421955	156639511	92611110	15	8846										
SELP	6403	broad.mit.edu	37	chr1	169578782	169578782	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gctgtccactgtcccaagttAtcacaccgaactatatcggc	7	14	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:169578782A>G	uc001ggi.3	-	8	1358	c.1293T>C	c.(1291-1293)GAT>GAC	p.D431D	SELP_uc001ggh.2_Silent_p.D266D|SELP_uc009wvr.2_Silent_p.D431D	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	431	Sushi 4.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GTCCCAAGTTATCACACCGAA	0.488													0	0	0	0.01441	0	42	32										G	169578782	A	G	169578782	2	3	36	1	0	0	0	0	0	0	0	1	14019	446	16	5		5	SELP	1	169578782	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	12939271	169578782	79671839	16	8847										
DNM3	26052	broad.mit.edu	37	chr1	172007570	172007570	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acaaaaatttcaaaccagaaGacccaacaaggaagaccaaa	5	10	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:172007570G>A	uc001gie.2	+	7	1137	c.961G>A	c.(961-963)GAC>AAC	p.D321N	DNM3_uc001gid.3_Missense_Mutation_p.D321N|DNM3_uc009wwb.2_Missense_Mutation_p.D321N|DNM3_uc001gif.2_Missense_Mutation_p.D321N	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	321					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CAAACCAGAAGACCCAACAAG	0.418													0	0	0	0.01441	0	90	78										A	172007570	G	A	172007570	3	1	36	1	0	0	0	0	1	0	0	0	4673	942	33	1	987	1	DNM3	1	172007570	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	2428788	172007570	77243051	17	8848										
XPR1	9213	broad.mit.edu	37	chr1	180843056	180843056	+	Frame_Shift_Del	DEL	T	T	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gggacatcattgctactgtcTttgccccacttgaggttttc							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:180843056delT	uc001goi.2	+	13	1978	c.1786delT	c.(1786-1788)TTTfs	p.F596fs	XPR1_uc009wxn.2_Frame_Shift_Del_p.F531fs	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	596	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						TGCTACTGTCTTTGCCCCACT	0.368																		39	51	---	---								-	180843056	T	-	180843056	7	5	36	1	0	1	0	1	0	0	0	0	17448	1609	56	0	1836	0	XPR1	1	180843056	Frame_Shift_Del	DEL	T	TCGA-CU-A0YR-01A-12D-A10S-08	8835486	180843056	68407565	18	8849	43	2								
XPR1	9213	broad.mit.edu	37	chr1	180843064	180843064	+	Silent	SNP	A	A	G													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	attgctactgtctttgccccActtgaggttttccggtaagc							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:180843064A>G	uc001goi.2	+	13	1986	c.1794A>G	c.(1792-1794)CCA>CCG	p.P598P	XPR1_uc009wxn.2_Silent_p.P533P	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	598	EXS.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						TCTTTGCCCCACTTGAGGTTT	0.363													0	0	0	0.007835	0	40	37										G	180843064	A	G	180843064	2	3	36	1	0	0	0	0	0	0	0	1	17448	146	6	5		5	XPR1	1	180843064	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	8	180843064	68407557	19	8850	43	2								
ELF3	1999	broad.mit.edu	37	chr1	201982385	201982389	+	Frame_Shift_Del	DEL	AAGAG	AAGAG	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ccggccccgaaagctgagcaAagagtactgggactgtctcg					rs137861501		TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			AAGAG	-	AAGAG	AAGAG		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:201982385_201982389delAAGAG	uc001gxg.3	+	6	3956_3960	c.764_768delAAGAG	c.(763-768)AAAGAGfs	p.K255fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.K255fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.K255fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	255_256					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						AAGCTGAGCAAAGAGTACTGGGACT	0.644																		66	71	---	---								-	201982389	AAGAG	-	201982385	7	5	36	1	0	1	0	1	0	0	0	0	5055	14	1	0	786	0	ELF3	1	201982385	Frame_Shift_Del	DEL	AAGAG	TCGA-CU-A0YR-01A-12D-A10S-08	21139321	201982385	47268236	20	8851										
TRAF5	7188	broad.mit.edu	37	chr1	211529792	211529792	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cctggatgtaatgccaaggtTattctgggccggtaccaggt	13	9	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr1:211529792T>A	uc001hih.2	+	4	420	c.360T>A	c.(358-360)GTT>GTA	p.V120V	TRAF5_uc001hii.2_Silent_p.V120V|TRAF5_uc010psx.1_Silent_p.V120V|TRAF5_uc010psy.1_Silent_p.V120V|TRAF5_uc001hij.2_Silent_p.V120V	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	120					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		ATGCCAAGGTTATTCTGGGCC	0.378													0	0	0	0.014323	0	21	154										A	211529792	T	A	211529792	2	1	36	1	0	0	0	0	0	0	0	1	16441	1741	61	5		5	TRAF5	1	211529792	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	9547407	211529792	37720829	21	8852										
PNPT1	87178	broad.mit.edu	37	chr2	55895071	55895071	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aaggattctattatttcataTggatcggcttctggaaattt	8	5	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:55895071T>C	uc002rzf.2	-	12	1052	c.999A>G	c.(997-999)CCA>CCG	p.P333P	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	333					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TTATTTCATATGGATCGGCTT	0.274													0	0	0	0.010818	0	22	61										C	55895071	T	C	55895071	2	2	36	1	0	0	0	0	0	0	0	1	12173	1451	51	5		5	PNPT1	2	55895071	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08		55895071	187304302	22	8853										
PNPT1	87178	broad.mit.edu	37	chr2	55895089	55895089	+	Frame_Shift_Del	DEL	T	T	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tatggatcggcttctggaaaTttttctatagaaaaaagaca							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:55895089delT	uc002rzf.2	-	12	1034	c.981delA	c.(979-981)AAAfs	p.K327fs	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	327					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CTTCTGGAAATTTTTCTATAG	0.284																		19	65	---	---								-	55895089	T	-	55895089	7	5	36	1	0	1	0	1	0	0	0	0	12173	1490	52	0	1438	0	PNPT1	2	55895089	Frame_Shift_Del	DEL	T	TCGA-CU-A0YR-01A-12D-A10S-08	18	55895089	187304284	23	8854										
DYSF	8291	broad.mit.edu	37	chr2	71795448	71795448	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggacctgggctggagattgGttcgtgtgtccggagaagac	17	7	0	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:71795448G>T	uc002sie.2	+	26	3166	c.2790G>T	c.(2788-2790)TGG>TGT	p.W930C	DYSF_uc010feg.2_Missense_Mutation_p.W961C|DYSF_uc010feh.2_Missense_Mutation_p.W916C|DYSF_uc002sig.3_Missense_Mutation_p.W916C|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.W930C|DYSF_uc010fef.2_Missense_Mutation_p.W947C|DYSF_uc010fei.2_Missense_Mutation_p.W947C|DYSF_uc010fek.2_Missense_Mutation_p.W948C|DYSF_uc010fej.2_Missense_Mutation_p.W917C|DYSF_uc010fel.2_Missense_Mutation_p.W917C|DYSF_uc010feo.2_Missense_Mutation_p.W962C|DYSF_uc010fem.2_Missense_Mutation_p.W931C|DYSF_uc010fen.2_Missense_Mutation_p.W948C|DYSF_uc002sif.2_Missense_Mutation_p.W931C	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	930	Cytoplasmic (Potential).		W -> C (in LGMD2B; uncetain pathogenicity).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTGGAGATTGGTTCGTGTGTC	0.647													1	0	2.56588e-125	0.01441	2.86143e-125	222	460										T	71795448	G	T	71795448	3	4	36	1	0	0	0	0	1	0	0	0	4859	1270	44	4	3084	4	DYSF	2	71795448	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	15900359	71795448	171403925	24	8855										
SLC5A7	60482	broad.mit.edu	37	chr2	108604766	108604766	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggccgagatattggtttatTggttggtggatttaccatga	13	4	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:108604766T>C	uc002tdv.2	+	2	431	c.155T>C	c.(154-156)TTG>TCG	p.L52S	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.L52S|SLC5A7_uc010ywn.1_Intron	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	52	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	ATTGGTTTATTGGTTGGTGGA	0.542													0	0	0	0.012213	0	30	76										C	108604766	T	C	108604766	3	2	36	1	0	0	0	0	1	0	0	0	14670	1821	63	5	157	5	SLC5A7	2	108604766	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	36809318	108604766	134594607	25	8856										
THSD7B	80731	broad.mit.edu	37	chr2	137814383	137814383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttgcctcattccttgtccccGggattgtgtagtatctgagt	10	10	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:137814383G>A	uc002tva.1	+	2	440	c.440G>A	c.(439-441)CGG>CAG	p.R147Q	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.R37Q	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTTGTCCCCGGGATTGTGTA	0.498													0	0	0	0.01441	0	48	324										A	137814383	G	A	137814383	3	1	36	1	0	0	0	0	1	0	0	0	15877	1116	39	2	446	2	THSD7B	2	137814383	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	29209617	137814383	105384990	26	8857										
PKP4	8502	broad.mit.edu	37	chr2	159519804	159519804	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgggatggagttggtcctatCccaggactgtcgaagtcccc	13	11	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:159519804C>T	uc002tzv.2	+	15	2684	c.2424C>T	c.(2422-2424)ATC>ATT	p.I808I	PKP4_uc002tzu.2_Silent_p.I808I|PKP4_uc002tzw.2_Silent_p.I808I|PKP4_uc002tzx.2_Silent_p.I465I|PKP4_uc002uaa.2_Silent_p.I660I|uc002uab.1_Intron|PKP4_uc002uac.2_5'UTR	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	808					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TTGGTCCTATCCCAGGACTGT	0.483										HNSCC(62;0.18)			0	0	0	0.012319	0	21	54										T	159519804	C	T	159519804	2	4	36	1	0	0	0	0	0	0	0	1	11987	845	30	1		1	PKP4	2	159519804	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	21705421	159519804	83679569	27	8858										
XIRP2	129446	broad.mit.edu	37	chr2	168104737	168104737	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	atccaatcaactttaaccctGagaataatgtaaaagaaagt	5	7	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:168104737G>A	uc002udx.2	+	8	6853	c.6835G>A	c.(6835-6837)GAG>AAG	p.E2279K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E2104K|XIRP2_uc010fpq.2_Missense_Mutation_p.E2057K|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2104					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTTTAACCCTGAGAATAATGT	0.413													0	0	0	0.017118	0	36	88										A	168104737	G	A	168104737	3	1	36	1	0	0	0	0	1	0	0	0	17427	1291	45	1	6865	1	XIRP2	2	168104737	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	8584933	168104737	75094636	28	8859										
TTN	7273	broad.mit.edu	37	chr2	179616127	179616127	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	catcatacatgtaatctgttTtcttggcagaactcattgtc	6	9	4	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:179616127T>G	uc002unb.2	-	46	11224	c.11000A>C	c.(10999-11001)AAA>ACA	p.K3667T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAATCTGTTTTCTTGGCAGA	0.363													0	0	0	0.01441	0	50	106										G	179616127	T	G	179616127	3	3	36	1	0	0	0	0	1	0	0	0	16732	1841	64	5	99297	5	TTN	2	179616127	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	11511390	179616127	63583246	29	8860										
ADAM23	8745	broad.mit.edu	37	chr2	207436497	207436497	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	atgttccctctccaacggggCtcactgcagcgacgggccct	11	16	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr2:207436497C>A	uc002vbq.2	+	17	1836	c.1613C>A	c.(1612-1614)GCT>GAT	p.A538D	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	538	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TCCAACGGGGCTCACTGCAGC	0.443													1	0	1.99824e-07	0.00499	2.09667e-07	14	124										A	207436497	C	A	207436497	3	1	36	1	0	0	0	0	1	0	0	0	245	797	28	4	1679	4	ADAM23	2	207436497	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	27820370	207436497	35762876	30	8861										
SUMF1	285362	broad.mit.edu	37	chr3	4508955	4508955	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cccgcgggccatgtgacccgGttggtcacgtggctgagccc	15	15	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:4508955G>C	uc003bpz.1	-	1	1	c.-24_splice	c.e1-1		SUMF1_uc003bps.1_Splice_Site|SUMF1_uc011ass.1_Splice_Site|SUMF1_uc010hby.1_Splice_Site|SUMF1_uc011ast.1_Splice_Site	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1							endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		ATGTGACCCGGTTGGTCACGT	0.577													0	0	0	0.014758	0	5	16										C	4508955	G	C	4508955	5	2	36	1	0	0	0	0	0	0	1	0	15382	1276	44	4		4	SUMF1	3	4508955	Splice_Site	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08		4508955	193513475	31	8862										
MYRIP	25924	broad.mit.edu	37	chr3	40192632	40192632	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aaggttctgaagaacctgtaCaggaagcaccggctggagag	14	8	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:40192632C>T	uc003cka.2	+	4	561	c.426C>T	c.(424-426)TAC>TAT	p.Y142Y	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Silent_p.Y142Y|MYRIP_uc010hhw.2_Intron|MYRIP_uc010hhx.1_Silent_p.Y142Y|MYRIP_uc011ayz.1_5'UTR	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	142					intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		AGAACCTGTACAGGAAGCACC	0.552													0	0	0	0.010729	0	8	24										T	40192632	C	T	40192632	2	4	36	1	0	0	0	0	0	0	0	1	10100	489	17	2		2	MYRIP	3	40192632	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	35683677	40192632	157829798	32	8863										
VIPR1	7433	broad.mit.edu	37	chr3	42577695	42577695	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aacggcgccacgtgcagcacGcaggtttccatgctgacccg	12	15	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:42577695G>T	uc003clf.2	+	13	1420	c.1296G>T	c.(1294-1296)ACG>ACT	p.T432T	VIPR1_uc011azl.1_Silent_p.T384T|VIPR1_uc011azm.1_Silent_p.T222T|VIPR1_uc011azn.1_Silent_p.T405T|VIPR1_uc003clg.2_Silent_p.T77T	NM_004624	NP_004615	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	432	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CGTGCAGCACGCAGGTTTCCA	0.692													1	0	0.00909568	0.009096	0.00931433	4	15										T	42577695	G	T	42577695	2	4	36	1	0	0	0	0	0	0	0	1	17166	1074	38	4		4	VIPR1	3	42577695	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	2385063	42577695	155444735	33	8864										
BAP1	8314	broad.mit.edu	37	chr3	52440379	52440379	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	catcaggttgaagcggatgtCgtggtagggctccctgcagt	15	9	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:52440379C>G	uc003ddx.2	-	9	788	c.673G>C	c.(673-675)GAC>CAC	p.D225H	BAP1_uc003ddw.2_5'Flank|BAP1_uc010hmg.2_5'Flank|BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	225					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		AAGCGGATGTCGTGGTAGGGC	0.632			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.00632	0	25	21										G	52440379	C	G	52440379	3	3	36	1	0	0	0	0	1	0	0	0	1311	884	31	1	1552	1	BAP1	3	52440379	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	9862684	52440379	145582051	34	8865										
TPRA1	131601	broad.mit.edu	37	chr3	127294260	127294260	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acgcaccagagcccctcgatGatgtcgaagcacagcagcac	10	15	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:127294260G>A	uc003ejl.2	-	8	1050	c.759C>T	c.(757-759)ATC>ATT	p.I253I	TPRA1_uc003ejm.2_RNA|TPRA1_uc003ejo.2_Silent_p.I253I|TPRA1_uc010hsk.2_Intron|TPRA1_uc003ejn.2_Silent_p.I253I	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	253	Helical; Name=6; (Potential).				aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						GCCCCTCGATGATGTCGAAGC	0.682											OREG0015772	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	6	22										A	127294260	G	A	127294260	2	1	36	1	0	0	0	0	0	0	0	1	16414	1280	45	1		1	TPRA1	3	127294260	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	74853881	127294260	70728170	35	8866										
COL6A6	131873	broad.mit.edu	37	chr3	130292969	130292969	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagtttagcgatacctatcaCccggagtttccactgggaac	9	12	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:130292969C>A	uc010htl.2	+	7	3178	c.3147C>A	c.(3145-3147)CAC>CAA	p.H1049Q		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1049	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ATACCTATCACCCGGAGTTTC	0.433													1	0	1.10513e-12	0.014323	1.17697e-12	24	56										A	130292969	C	A	130292969	3	1	36	1	0	0	0	0	1	0	0	0	3703	506	18	4	3173	4	COL6A6	3	130292969	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	2998709	130292969	67729461	36	8867										
DNAJC13	23317	broad.mit.edu	37	chr3	132247081	132247081	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tcttaaaattactcgaaggcAttggccttgaaaacctggac	8	9	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:132247081A>G	uc003eor.2	+	54	6495	c.6430A>G	c.(6430-6432)ATT>GTT	p.I2144V		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	2144							heat shock protein binding			ovary(1)|breast(1)	2						ACTCGAAGGCATTGGCCTTGA	0.418													0	0	0	0.009535	0	33	78										G	132247081	A	G	132247081	3	3	36	1	0	0	0	0	1	0	0	0	4632	217	8	5	6640	5	DNAJC13	3	132247081	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	1954112	132247081	65775349	37	8868										
SKIL	6498	broad.mit.edu	37	chr3	170079087	170079087	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ccactggggctttgaatcagCtaaatggcattgctatcttc	9	10	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr3:170079087C>T	uc003fgu.2	+	2	1680	c.968C>T	c.(967-969)GCT>GTT	p.A323V	SKIL_uc011bps.1_Missense_Mutation_p.A303V|SKIL_uc003fgv.2_Missense_Mutation_p.A323V|SKIL_uc003fgw.2_Missense_Mutation_p.A323V	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	323					cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TTTGAATCAGCTAAATGGCAT	0.398													0	0	0	0.005524	0	34	196										T	170079087	C	T	170079087	3	4	36	1	0	0	0	0	1	0	0	0	14358	797	28	2	970	2	SKIL	3	170079087	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	37832006	170079087	27943343	38	8869										
LETM1	3954	broad.mit.edu	37	chr4	1824768	1824768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acggtgctcctgctggatggCcgcctcctcctgcagcgtgg	14	15	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:1824768C>T	uc003gdv.2	-	9	1720	c.1423G>A	c.(1423-1425)GCC>ACC	p.A475T		NM_012318	NP_036450	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane	475	Mitochondrial matrix (Potential).|Potential.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			central_nervous_system(1)	1			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			TGCTGGATGGCCGCCTCCTCC	0.652													0	0	0	0.016723	0	14	106										T	1824768	C	T	1824768	3	4	36	1	0	0	0	0	1	0	0	0	8734	739	26	2	820	2	LETM1	4	1824768	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08		1824768	189329508	39	8870										
PGM2	55276	broad.mit.edu	37	chr4	37850207	37850207	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gccgctgtcataagtgcagaGttggctagcttcctagcaac	11	11	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:37850207G>A	uc011byb.1	+	11	1420	c.1347G>A	c.(1345-1347)GAG>GAA	p.E449E	PGM2_uc011byc.1_Silent_p.E289E	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	449					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						TAAGTGCAGAGTTGGCTAGCT	0.408													0	0	0	0.01441	0	58	85										A	37850207	G	A	37850207	2	1	36	1	0	0	0	0	0	0	0	1	11798	1020	36	2		2	PGM2	4	37850207	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	36025439	37850207	153304069	40	8871										
UGT2A3	79799	broad.mit.edu	37	chr4	69817427	69817427	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cccacagaatccacagccaaCacagaagagctgcaggagca	9	14	0	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:69817427C>T	uc003hef.2	-	1	83	c.52G>A	c.(52-54)GTT>ATT	p.V18I	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	18						integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CCACAGCCAACACAGAAGAGC	0.478													0	0	0	0.013726	0	18	65										T	69817427	C	T	69817427	3	4	36	1	0	0	0	0	1	0	0	0	16952	478	17	2	1555	2	UGT2A3	4	69817427	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	31967220	69817427	121336849	41	8872										
UGT2B7	7364	broad.mit.edu	37	chr4	69962362	69962362	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	attggatgaatataaagacaAtcctggatgagcttattcag	9	5	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:69962362A>G	uc003heg.3	+	1	170	c.124A>G	c.(124-126)ATC>GTC	p.I42V	UGT2B7_uc010ihq.2_Missense_Mutation_p.I42V	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	42					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TATAAAGACAATCCTGGATGA	0.418													0	0	0	0.01441	0	64	141										G	69962362	A	G	69962362	3	3	36	1	0	0	0	0	1	0	0	0	16959	101	4	5	126	5	UGT2B7	4	69962362	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	144935	69962362	121191914	42	8873										
HNRPDL	9987	broad.mit.edu	37	chr4	83347685	83347685	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cccagtataatcatatccgcCatagccactatagttttgat	5	11	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:83347685C>T	uc003hmr.2	-	6	1658	c.1123G>A	c.(1123-1125)GGC>AGC	p.G375S	HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Intron	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	375	Tyr-rich.|Necessary for interaction with TNPO1.|Gly-rich.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				TCATATCCGCCATAGCCACTA	0.353													0	0	0	0.009535	0	26	75										T	83347685	C	T	83347685	3	4	36	1	0	0	0	0	1	0	0	0	7276	594	21	2	147	2	HNRPDL	4	83347685	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	13385323	83347685	107806591	43	8874										
MYOZ2	51778	broad.mit.edu	37	chr4	120107259	120107259	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tctggcagacggtcctttaaTaggactcctaagggatggat	12	8	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:120107259T>C	uc003icp.3	+	6	912	c.699T>C	c.(697-699)AAT>AAC	p.N233N		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	233							protein phosphatase 2B binding				0						GGTCCTTTAATAGGACTCCTA	0.393													0	0	0	0.014323	0	22	72										C	120107259	T	C	120107259	2	2	36	1	0	0	0	0	0	0	0	1	10096	1403	49	5		5	MYOZ2	4	120107259	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	36759574	120107259	71047017	44	8875										
MYOZ2	51778	broad.mit.edu	37	chr4	120107338	120107338	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagatgataccactgtaccaGaatcagaagacctatgaaaa	7	9	1	6			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:120107338G>C	uc003icp.3	+	6	991	c.778G>C	c.(778-780)GAA>CAA	p.E260Q		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	260							protein phosphatase 2B binding				0						CACTGTACCAGAATCAGAAGA	0.383													0	0	0	0.020292	0	14	48										C	120107338	G	C	120107338	3	2	36	1	0	0	0	0	1	0	0	0	10096	943	33	1	796	1	MYOZ2	4	120107338	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	79	120107338	71046938	45	8876										
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gccatcatattgaacacagcGgactgctgcaacatgaccca	8	13	1	2	rs149680468		TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.010504	0	21	107										C	153247289	G	C	153247289	3	2	36	1	0	0	0	0	1	0	0	0	5769	1116	39	4	622	4	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	33139951	153247289	37906987	46	8877										
WWC2	80014	broad.mit.edu	37	chr4	184114848	184114848	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagattggtgtctactacatCgatcacatcaacagtaagtt	7	9	3	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr4:184114848C>G	uc010irx.2	+	2	410	c.228C>G	c.(226-228)ATC>ATG	p.I76M	WWC2_uc003ivk.3_Translation_Start_Site	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	76	WW 2.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TCTACTACATCGATCACATCA	0.423													0	0	0	0.00499	0	16	38										G	184114848	C	G	184114848	3	3	36	1	0	0	0	0	1	0	0	0	17409	874	31	1	234	1	WWC2	4	184114848	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	30867559	184114848	7039428	47	8878										
ZDHHC11	79844	broad.mit.edu	37	chr5	837498	837498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acctggagaactcctttgtcCatttgcacgtatggatcttt	8	10	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:837498C>T	uc011cma.1	-	6	1266	c.882G>A	c.(880-882)ATG>ATA	p.M294I	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	294						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CTCCTTTGTCCATTTGCACGT	0.483													0	0	0	0.01441	0	53	307										T	837498	C	T	837498	3	4	36	1	0	0	0	0	1	0	0	0	17598	594	21	2	384	2	ZDHHC11	5	837498	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08		837498	180077762	48	8879										
C5orf42	65250	broad.mit.edu	37	chr5	37183002	37183002	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgactcagttataccagaatCacagagtagccttctattag	7	9	3	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:37183002C>T	uc011cpa.1	-	26	5512	c.5281G>A	c.(5281-5283)GAT>AAT	p.D1761N	C5orf42_uc011coy.1_Missense_Mutation_p.D262N|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.D836N|C5orf42_uc011cpb.1_Missense_Mutation_p.D642N	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1761										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATACCAGAATCACAGAGTAGC	0.413													0	0	0	0.013114	0	44	74										T	37183002	C	T	37183002	3	4	36	1	0	0	0	0	1	0	0	0	2301	826	29	1	4420	1	C5orf42	5	37183002	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	36345504	37183002	143732258	49	8880										
NUP155	9631	broad.mit.edu	37	chr5	37293028	37293028	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttctcaacatatcttatcaaTaatacatgtatacaatccaa	1	9	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:37293028T>C	uc003jku.1	-	34	4108	c.3990A>G	c.(3988-3990)TTA>TTG	p.L1330L	NUP155_uc003jkt.1_Silent_p.L1271L|NUP155_uc010iuz.1_Silent_p.L1266L	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1330					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATCTTATCAATAATACATGTA	0.313													0	0	0	0.01441	0	69	137										C	37293028	T	C	37293028	2	2	36	1	0	0	0	0	0	0	0	1	10756	1403	49	5		5	NUP155	5	37293028	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	110026	37293028	143622232	50	8881										
SKIV2L2	23517	broad.mit.edu	37	chr5	54649078	54649078	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tacaaatgcccgcaaatttgAtgggaaggatttccgatggg	12	7	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:54649078A>T	uc003jpy.3	+	14	1780	c.1514A>T	c.(1513-1515)GAT>GTT	p.D505V	SKIV2L2_uc011cqi.1_Missense_Mutation_p.D404V	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	505	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				CGCAAATTTGATGGGAAGGAT	0.333													0	0	0	0.014323	0	21	134										T	54649078	A	T	54649078	3	4	36	1	0	0	0	0	1	0	0	0	14360	333	12	5	1568	5	SKIV2L2	5	54649078	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	17356050	54649078	126266182	51	8882										
FAM169A	26049	broad.mit.edu	37	chr5	74077398	74077398	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tatttcctctgagctgctatCcacagctttttctgccgatt	6	12	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:74077398C>A	uc003kdm.2	-	13	1943	c.1900G>T	c.(1900-1902)GAT>TAT	p.D634Y	FAM169A_uc010izm.2_Missense_Mutation_p.D574Y|FAM169A_uc003kdl.2_Missense_Mutation_p.D452Y	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	634											0						GAGCTGCTATCCACAGCTTTT	0.458													1	0	1.27862e-28	0.01441	1.38952e-28	59	204										A	74077398	C	A	74077398	3	1	36	1	0	0	0	0	1	0	0	0	5487	855	30	3	116	3	FAM169A	5	74077398	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	19428320	74077398	106837862	52	8883										
TMCO6	55374	broad.mit.edu	37	chr5	140024591	140024591	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctgttcaggtcttcctgcagCagtcagggctgcaagccctg	12	13	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:140024591C>T	uc003lgl.2	+	12	1491	c.1390C>T	c.(1390-1392)CAG>TAG	p.Q464*	TMCO6_uc003lgm.2_Nonsense_Mutation_p.Q470*|TMCO6_uc010jft.2_Nonsense_Mutation_p.Q224*|TMCO6_uc003lgn.2_Nonsense_Mutation_p.Q355*|TMCO6_uc003lgo.2_Nonsense_Mutation_p.Q224*|IK_uc011czk.1_5'Flank|IK_uc003lgq.2_5'Flank	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	464					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCTGCAGCAGTCAGGGCT	0.542													0	0	0	0.01441	0	97	144										T	140024591	C	T	140024591	4	4	36	1	0	0	0	0	0	1	0	0	15997	711	25	2	1436	2	TMCO6	5	140024591	Nonsense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	65947193	140024591	40890669	53	8884										
PCDHAC1	56135	broad.mit.edu	37	chr5	140308488	140308488	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttccagactttgaagatgtcTgggaaccaggagggcagctt	13	8	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:140308488T>C	uc003lih.2	+	1	2187	c.2011T>C	c.(2011-2013)TGG>CGG	p.W671R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.W671R	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	671	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGATGTCTGGGAACCAGG	0.483													0	0	0	0.01441	0	58	241										C	140308488	T	C	140308488	3	2	36	1	0	0	0	0	1	0	0	0	11532	1580	55	5	2013	5	PCDHAC1	5	140308488	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	283897	140308488	40606772	54	8885										
CSF1R	1436	broad.mit.edu	37	chr5	149460456	149460456	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gctgctggagccatcagagtAcagggtccagtgaggtgatg	16	8	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:149460456A>G	uc003lrl.2	-	2	376	c.181T>C	c.(181-183)TAC>CAC	p.Y61H	CSF1R_uc011dcd.1_5'UTR|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.Y61H|CSF1R_uc011dce.1_Missense_Mutation_p.Y61H|CSF1R_uc011dcf.1_Missense_Mutation_p.Y61H	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	61	Ig-like C2-type 1.|Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity	p.Y61Y(2)		haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CCATCAGAGTACAGGGTCCAG	0.612													0	0	0	0.004007	0	15	51										G	149460456	A	G	149460456	3	3	36	1	0	0	0	0	1	0	0	0	3932	391	14	5	2817	5	CSF1R	5	149460456	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	9151968	149460456	31454804	55	8886										
SLC36A1	206358	broad.mit.edu	37	chr5	150844717	150844717	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gctcctggctccggaaccacGcacactggggaaggtaactg	13	13	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:150844717G>A	uc003luc.2	+	5	623	c.406G>A	c.(406-408)GCA>ACA	p.A136T	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.A136T|SLC36A1_uc010jhw.1_Missense_Mutation_p.A136T	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	136	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCGGAACCACGCACACTGGGG	0.493													0	0	0	0.019004	0	31	84										A	150844717	G	A	150844717	3	1	36	1	0	0	0	0	1	0	0	0	14593	1087	38	2	420	2	SLC36A1	5	150844717	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	1384261	150844717	30070543	56	8887										
NSD1	64324	broad.mit.edu	37	chr5	176562709	176562709	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgagactaaatcagagaatgGtgtaaaagtggccatgggaa	13	4	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:176562709G>A	uc003mfr.3	+	2	743	c.605G>A	c.(604-606)GGT>GAT	p.G202D	NSD1_uc003mft.3_Intron|NSD1_uc003mfs.1_Missense_Mutation_p.G202D|NSD1_uc011dfx.1_Intron|NSD1_uc003mfp.2_Missense_Mutation_p.G202D|NSD1_uc003mfq.2_Missense_Mutation_p.G202D	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	202					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCAGAGAATGGTGTAAAAGTG	0.468			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.01441	0	58	100										A	176562709	G	A	176562709	3	1	36	1	0	0	0	0	1	0	0	0	10669	1261	44	2	607	2	NSD1	5	176562709	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	25717992	176562709	4352551	57	8888										
MGAT1	4245	broad.mit.edu	37	chr5	180219243	180219243	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	accatctgctccttgccgttGtcattccaggccgagacgca	9	15	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:180219243G>T	uc003mmg.3	-	2	1224	c.729C>A	c.(727-729)GAC>GAA	p.D243E	MGAT1_uc010jlf.2_Missense_Mutation_p.D243E|MGAT1_uc010jlg.2_Missense_Mutation_p.D243E|MGAT1_uc003mmh.3_Missense_Mutation_p.D243E|MGAT1_uc010jlh.2_Missense_Mutation_p.D243E|MGAT1_uc003mmi.3_Missense_Mutation_p.D243E	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	243	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTTGCCGTTGTCATTCCAGG	0.642													1	0	8.12818e-05	0.001984	8.40438e-05	7	140										T	180219243	G	T	180219243	3	4	36	1	0	0	0	0	1	0	0	0	9542	1368	48	4	612	4	MGAT1	5	180219243	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	3656534	180219243	696017	58	8889										
OR2V2	285659	broad.mit.edu	37	chr5	180581946	180581946	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ggagcaacaaccgagccatgGagacgtgggtgaaccagtcc	14	11	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr5:180581946G>C	uc011dhj.1	+	1	4	c.4G>C	c.(4-6)GAG>CAG	p.E2Q		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGAGCCATGGAGACGTGGGT	0.493													0	0	0	0.01441	0	72	109										C	180581946	G	C	180581946	3	2	36	1	0	0	0	0	1	0	0	0	11031	1175	41	1	6	1	OR2V2	5	180581946	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	362703	180581946	333314	59	8890										
CAP2	10486	broad.mit.edu	37	chr6	17539634	17539634	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ggcaaaaaagaggaatcttcTccttcacgctcagctttatt	7	10	4	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:17539634T>C	uc003ncb.2	+	8	1014	c.771T>C	c.(769-771)TCT>TCC	p.S257S	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Silent_p.S231S|CAP2_uc011djb.1_Silent_p.S193S|CAP2_uc011djc.1_Silent_p.S145S|CAP2_uc011djd.1_Intron	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	257					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			AGGAATCTTCTCCTTCACGCT	0.522													0	0	0	0.001168	0	6	117										C	17539634	T	C	17539634	2	2	36	1	0	0	0	0	0	0	0	1	2620	1538	54	5		5	CAP2	6	17539634	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08		17539634	153575433	60	8891										
GPX6	257202	broad.mit.edu	37	chr6	28474199	28474199	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttcagctcctcctgtagtgcAttcagttctgtaagtggaca	9	10	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:28474199A>C	uc011dlj.1	-	4	299	c.249T>G	c.(247-249)AAT>AAG	p.N83K	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	83					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	CCTGTAGTGCATTCAGTTCTG	0.443													0	0	0	0.012319	0	20	119										C	28474199	A	C	28474199	3	2	36	1	0	0	0	0	1	0	0	0	6744	214	8	5	428	5	GPX6	6	28474199	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	10934565	28474199	142640868	61	8892										
BTNL2	56244	broad.mit.edu	37	chr6	32372796	32372796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agtattgtccattgtcggagGgctggatgttgtgtatcttc	13	6	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:32372796G>A	uc003obg.1	-	2	347	c.347C>T	c.(346-348)CCC>CTC	p.P116L	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	116	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						ATTGTCGGAGGGCTGGATGTT	0.488													0	0	0	0.021022	0	36	179										A	32372796	G	A	32372796	3	1	36	1	0	0	0	0	1	0	0	0	1565	1232	43	2	1040	2	BTNL2	6	32372796	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	3898597	32372796	138742271	62	8893										
ZBTB22	9278	broad.mit.edu	37	chr6	33284382	33284382	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gaggctaggacagtctcaaaGgcgcctgggtccatgacact	13	11	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:33284382G>A	uc003oeb.2	-	2	464	c.312C>T	c.(310-312)GCC>GCT	p.A104A	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.A104A	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	104	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGTCTCAAAGGCGCCTGGGT	0.577													0	0	0	0.01441	0	52	210										A	33284382	G	A	33284382	2	1	36	1	0	0	0	0	0	0	0	1	17527	987	35	2		2	ZBTB22	6	33284382	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	911586	33284382	137830685	63	8894										
SLC17A5	26503	broad.mit.edu	37	chr6	74331540	74331540	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttcttacctcttgaacattgAaccttaggatctccttcata	4	11	4	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:74331540A>G	uc003phn.3	-	7	1093	c.965T>C	c.(964-966)TTC>TCC	p.F322S	SLC17A5_uc010kax.2_Intron|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Missense_Mutation_p.F191S	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	322					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						TTGAACATTGAACCTTAGGAT	0.313													0	0	0	0.013537	0	12	36										G	74331540	A	G	74331540	3	3	36	1	0	0	0	0	1	0	0	0	14420	246	9	5	542	5	SLC17A5	6	74331540	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	41047158	74331540	96783527	64	8895										
SIM1	6492	broad.mit.edu	37	chr6	100868687	100868688	+	Nonsense_Mutation	DNP	GG	GG	TC													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgagggtatggggaagtcctGgattttgactttgagctgga							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:100868687_100868688GG>TC	uc003pqj.3	-	9	1352_1353	c.1145_1146CC>GA	c.(1144-1146)TCC>TGA	p.S382*	SIM1_uc010kcu.2_Nonsense_Mutation_p.S382*	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	382	Single-minded C-terminal.|Nuclear localization signal (By similarity).				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGGAAGTCCTGGATTTTGACTT	0.47													0	0	0	0.004672	0	47	84										TC	100868688	GG	TC	100868687	4	4	36	1	0	0	0	0	0	1	0	0	14323	1335	47	4	1166	4	SIM1	6	100868687	Nonsense_Mutation	DNP	GG	TCGA-CU-A0YR-01A-12D-A10S-08	26537147	100868687	70246380	65	8896										
LAMA2	3908	broad.mit.edu	37	chr6	129498972	129498972	+	Frame_Shift_Del	DEL	C	C	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aactgcagtgggttagggagCaaaaatgaggatccttgttt							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:129498972delC	uc003qbn.2	+	10	1533	c.1428delC	c.(1426-1428)AGCfs	p.S476fs	LAMA2_uc003qbo.2_Frame_Shift_Del_p.S476fs	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	476	Laminin EGF-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGTTAGGGAGCAAAAATGAGG	0.478																		37	83	---	---								-	129498972	C	-	129498972	7	5	36	1	0	1	0	1	0	0	0	0	8606	709	25	0	1466	0	LAMA2	6	129498972	Frame_Shift_Del	DEL	C	TCGA-CU-A0YR-01A-12D-A10S-08	28630285	129498972	41616095	66	8897										
RAET1G	353091	broad.mit.edu	37	chr6	150240778	150240778	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtactgggttctgtgctttcCaggccgttgtgacatttagt	12	8	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:150240778C>A	uc010kii.1	-	2	328	c.260G>T	c.(259-261)TGG>TTG	p.W87L	RAET1G_uc003qnm.2_RNA	NM_001001788	NP_001001788	Q6H3X3	RET1G_HUMAN	retinoic acid early transcript 1G precursor	87	MHC class I alpha-1 like.|Extracellular (Potential).				antigen processing and presentation|immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.73e-12)		CTGTGCTTTCCAGGCCGTTGT	0.488													1	0	3.36649e-63	0.01441	3.7347e-63	125	181										A	150240778	C	A	150240778	3	1	36	1	0	0	0	0	1	0	0	0	13000	595	21	4	760	4	RAET1G	6	150240778	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	20741806	150240778	20874289	67	8898										
ARID1B	57492	broad.mit.edu	37	chr6	157521944	157521944	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agcagcaggagatgtacaacCagtatggaggctcctactcg	12	10	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr6:157521944C>G	uc003qqn.2	+	18	4314	c.4162C>G	c.(4162-4164)CAG>GAG	p.Q1388E	ARID1B_uc003qqo.2_Missense_Mutation_p.Q1348E|ARID1B_uc003qqp.2_Missense_Mutation_p.Q1335E	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1393					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GATGTACAACCAGTATGGAGG	0.632													0	0	0	0.010504	0	20	108										G	157521944	C	G	157521944	3	3	36	1	0	0	0	0	1	0	0	0	914	595	21	4	4286	4	ARID1B	6	157521944	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	7281166	157521944	13593123	68	8899										
FAM126A	84668	broad.mit.edu	37	chr7	22985595	22985595	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gattcccctgtagtttctttTtcttttcctccagttttgct	5	11	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:22985595T>C	uc003svm.3	-	11	1434	c.1179A>G	c.(1177-1179)GAA>GAG	p.E393E	FAM126A_uc003svn.3_3'UTR	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	393						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						TAGTTTCTTTTTCTTTTCCTC	0.418													0	0	0	0.01441	0	113	195										C	22985595	T	C	22985595	2	2	36	1	0	0	0	0	0	0	0	1	5429	1838	64	5		5	FAM126A	7	22985595	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08		22985595	136153068	69	8900										
GLI3	2737	broad.mit.edu	37	chr7	42004980	42004980	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acttccggggctgttgtggaGcatcaagtgctctgggccac	14	11	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:42004980G>T	uc011kbh.1	-	15	3782	c.3691C>A	c.(3691-3693)CTC>ATC	p.L1231I	GLI3_uc011kbg.1_Missense_Mutation_p.L1172I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1231					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGTTGTGGAGCATCAAGTGC	0.632									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				1	0	1.41504e-22	0.011902	1.52996e-22	41	94										T	42004980	G	T	42004980	3	4	36	1	0	0	0	0	1	0	0	0	6439	971	34	4	1055	4	GLI3	7	42004980	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	19019385	42004980	117133683	70	8901										
OGDH	4967	broad.mit.edu	37	chr7	44736651	44736651	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gagcggccaggacgtggagcGgggcacattcaggtaacgtt	17	9	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:44736651G>A	uc003tln.2	+	15	2148	c.2039G>A	c.(2038-2040)CGG>CAG	p.R680Q	OGDH_uc011kbx.1_Missense_Mutation_p.R676Q|OGDH_uc011kby.1_Missense_Mutation_p.R530Q|OGDH_uc003tlp.2_Missense_Mutation_p.R691Q|OGDH_uc011kbz.1_Missense_Mutation_p.R475Q|OGDH_uc003tlo.1_Missense_Mutation_p.R513Q	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	680					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GACGTGGAGCGGGGCACATTC	0.557													0	0	0	0.007413	0	17	108										A	44736651	G	A	44736651	3	1	36	1	0	0	0	0	1	0	0	0	10839	1116	39	2	2266	2	OGDH	7	44736651	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	2731671	44736651	114402012	71	8902										
ABCA13	154664	broad.mit.edu	37	chr7	48284188	48284188	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctcagattacagcatctgtgGaaattgcaaagcttgctgca	9	9	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:48284188G>A	uc003toq.2	+	11	1303	c.1278G>A	c.(1276-1278)TGG>TGA	p.W426*	ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	426					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGCATCTGTGGAAATTGCAAA	0.393													0	0	0	0.001168	0	6	47										A	48284188	G	A	48284188	4	1	36	1	0	0	0	0	0	1	0	0	31	1183	41	1	1149	1	ABCA13	7	48284188	Nonsense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	3547537	48284188	110854475	72	8903										
CPA2	1358	broad.mit.edu	37	chr7	129919306	129919318	+	Frame_Shift_Del	DEL	CTGGAGCCAGCAG	CTGGAGCCAGCAG	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cttctgcatctccccaggacCtggagccagcagcaaccctt							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:129919306_129919318delCTGGAGCCAGCAG	uc003vpq.2	+	9	810_822	c.791_803delCTGGAGCCAGCAG	c.(790-804)CCTGGAGCCAGCAGCfs	p.P264fs		NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	264_268					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TCCCCAGGACCTGGAGCCAGCAGCAACCCTTGC	0.502																		7	84	---	---								-	129919318	CTGGAGCCAGCAG	-	129919306	7	5	36	1	0	1	0	1	0	0	0	0	3790	681	24	0	825	0	CPA2	7	129919306	Frame_Shift_Del	DEL	CTGGAGCCAGCAG	TCGA-CU-A0YR-01A-12D-A10S-08	81635118	129919306	29219357	73	8904										
LUC7L2	51631	broad.mit.edu	37	chr7	139092032	139092032	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	taatgacagacgactggctgAtcattttgggggtaaactgc	12	7	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:139092032A>T	uc003vux.2	+	6	997	c.623A>T	c.(622-624)GAT>GTT	p.D208V	LUC7L2_uc011kqs.1_Missense_Mutation_p.D205V|LUC7L2_uc011kqt.1_Missense_Mutation_p.D274V|LUC7L2_uc003vuy.2_Missense_Mutation_p.D207V|LUC7L2_uc003vuz.1_Missense_Mutation_p.D155V|LUC7L2_uc003vva.2_Missense_Mutation_p.D155V	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	208	C2H2-type; atypical.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)					CGACTGGCTGATCATTTTGGG	0.398													0	0	0	0.00632	0	24	108										T	139092032	A	T	139092032	3	4	36	1	0	0	0	0	1	0	0	0	9083	333	12	5	645	5	LUC7L2	7	139092032	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	9172726	139092032	20046631	74	8905										
ABP1	26	broad.mit.edu	37	chr7	150554592	150554592	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cgtgcacttcggcggagagcGcattgcctatgaggtcagcg	15	11	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr7:150554592G>A	uc003why.1	+	3	5252	c.1034G>A	c.(1033-1035)CGC>CAC	p.R345H	ABP1_uc003whz.1_Missense_Mutation_p.R345H|ABP1_uc003wia.1_Missense_Mutation_p.R345H	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	345					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GGCGGAGAGCGCATTGCCTAT	0.642													0	0	0	0.014758	0	5	96										A	150554592	G	A	150554592	3	1	36	1	0	0	0	0	1	0	0	0	98	1087	38	2	1036	2	ABP1	7	150554592	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	11462560	150554592	8584071	75	8906										
MYST3	7994	broad.mit.edu	37	chr8	41794882	41794882	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caaacgacggaagtattctcTagggaaaagttcattttcat	8	7	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr8:41794882T>C	uc010lxb.2	-	17	3788	c.3244A>G	c.(3244-3246)AGA>GGA	p.R1082G	MYST3_uc010lxc.2_Missense_Mutation_p.R1082G|MYST3_uc003xon.3_Missense_Mutation_p.R1082G	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1082					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			AAGTATTCTCTAGGGAAAAGT	0.428													0	0	0	0.00874	0	43	59										C	41794882	T	C	41794882	3	2	36	1	0	0	0	0	1	0	0	0	10104	1530	53	5	2778	5	MYST3	8	41794882	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08		41794882	104569140	76	8907										
ATP6V1H	51606	broad.mit.edu	37	chr8	54745612	54745612	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tttcatttcaaacctctgaaTaaactcacaatcttcagcag	3	11	6	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr8:54745612T>A	uc003xrl.2	-	3	300	c.148A>T	c.(148-150)ATT>TTT	p.I50F	ATP6V1H_uc003xrk.2_Missense_Mutation_p.I10F|ATP6V1H_uc003xrm.2_Missense_Mutation_p.I50F|ATP6V1H_uc003xrn.2_Missense_Mutation_p.I50F|ATP6V1H_uc011ldv.1_Intron|ATP6V1H_uc010lyd.2_Intron|ATP6V1H_uc003xro.1_Missense_Mutation_p.I47F	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	50					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			AACCTCTGAATAAACTCACAA	0.368													0	0	0	0.01441	0	79	77										A	54745612	T	A	54745612	3	1	36	1	0	0	0	0	1	0	0	0	1189	1406	49	5	1351	5	ATP6V1H	8	54745612	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	12950730	54745612	91618410	77	8908										
MOS	4342	broad.mit.edu	37	chr8	57026488	57026488	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctgcagggccgcgcgtccacCgatggggaaaactcgctccg	14	15	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr8:57026488C>T	uc011leb.1	-	1	54	c.54G>A	c.(52-54)TCG>TCA	p.S18S		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	18							ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			GCGCGTCCACCGATGGGGAAA	0.697													0	0	0	0.003163	0	12	35										T	57026488	C	T	57026488	2	4	36	1	0	0	0	0	0	0	0	1	9712	639	23	2		2	MOS	8	57026488	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	2280876	57026488	89337534	78	8909										
IMPAD1	54928	broad.mit.edu	37	chr8	57905985	57906000	+	Frame_Shift_Del	DEL	CCGCGGGCCCCGCCGC	CCGCGGGCCCCGCCGC	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ggtgcccccatcggccgcggCcgcgggccccgccgcgccgc							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr8:57905985_57906000delCCGCGGGCCCCGCCGC	uc003xte.3	-	1	428_443	c.145_160delGCGGCGGGGCCCGCGG	c.(145-162)GCGGCGGGGCCCGCGGCCfs	p.A49fs		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	49_54	Poly-Ala.					Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				TcggccgcggccgcgggccccgccgcgccgccgccA	0.588																		5	9	---	---								-	57906000	CCGCGGGCCCCGCCGC	-	57905985	7	5	36	1	0	1	0	1	0	0	0	0	7725	739	26	0	939	0	IMPAD1	8	57905985	Frame_Shift_Del	DEL	CCGCGGGCCCCGCCGC	TCGA-CU-A0YR-01A-12D-A10S-08	879497	57905985	88458037	79	8910										
TRPS1	7227	broad.mit.edu	37	chr8	116632282	116632282	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aggggggttctttttccggaCcatatctgcaaagataaagg	12	7	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr8:116632282C>T	uc003ynz.2	-	2	463	c.4G>A	c.(4-6)GTC>ATC	p.V2I	TRPS1_uc011lhy.1_Missense_Mutation_p.V6I|TRPS1_uc003yny.2_Missense_Mutation_p.V15I|TRPS1_uc010mcy.2_Missense_Mutation_p.V2I	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	2					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTTTCCGGACCATATCTGCA	0.408									Langer-Giedion_syndrome				0	0	0	0.020292	0	14	87										T	116632282	C	T	116632282	3	4	36	1	0	0	0	0	1	0	0	0	16590	507	18	2	3861	2	TRPS1	8	116632282	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	58726297	116632282	29731740	80	8911										
COL22A1	169044	broad.mit.edu	37	chr8	139620181	139620181	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagccaaagagaactcacagGggttcctgaagggccaggct	13	11	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr8:139620181G>A	uc003yvd.2	-	57	4477	c.4030C>T	c.(4030-4032)CCT>TCT	p.P1344S	COL22A1_uc011ljo.1_Missense_Mutation_p.P624S	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1344	Pro-rich.|Gly-rich.|Collagen-like 13.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAACTCACAGGGGTTCCTGAA	0.512										HNSCC(7;0.00092)			0	0	0	0.00632	0	27	68										A	139620181	G	A	139620181	3	1	36	1	0	0	0	0	1	0	0	0	3681	1232	43	2	886	2	COL22A1	8	139620181	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	22987899	139620181	6743841	81	8912										
KCNV2	169522	broad.mit.edu	37	chr9	2718088	2718088	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggactactgcgagctggccGgcttccccaagacgcgccta	12	15	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:2718088G>A	uc003zho.1	+	1	563	c.349G>A	c.(349-351)GGC>AGC	p.G117S		NM_133497	NP_598004	Q8TDN2	KCNV2_HUMAN	potassium channel, subfamily V, member 2	117	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(50;0.0257)		CGAGCTGGCCGGCTTCCCCAA	0.667													0	0	0	0.009096	0	4	19										A	2718088	G	A	2718088	3	1	36	1	0	0	0	0	1	0	0	0	8095	1116	39	2	351	2	KCNV2	9	2718088	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08		2718088	138495343	82	8913										
DENND4C	55667	broad.mit.edu	37	chr9	19296129	19296129	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggtctccaaatccatcaatAcaaacaaatgcatttgttta	4	9	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:19296129A>G	uc003znq.2	+	2	250	c.217A>G	c.(217-219)ACA>GCA	p.T73A	DENND4C_uc011lnc.1_Translation_Start_Site	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	73	DENN.					integral to membrane				ovary(1)|skin(1)	2						ATCCATCAATACAAACAAATG	0.393													0	0	0	0.01441	0	87	169										G	19296129	A	G	19296129	3	3	36	1	0	0	0	0	1	0	0	0	4435	391	14	5	223	5	DENND4C	9	19296129	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	16578041	19296129	121917302	83	8914										
GNA14	9630	broad.mit.edu	37	chr9	80262686	80262686	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgcgactccttctcctccgcGgacaggcagcagcagccggc	12	17	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:80262686G>A	uc004aku.2	-	1	547	c.24C>T	c.(22-24)TCC>TCT	p.S8S		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	8					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TCTCCTCCGCGGACAGGCAGC	0.711													0	0	0	0.008291	0	9	14										A	80262686	G	A	80262686	2	1	36	1	0	0	0	0	0	0	0	1	6502	1103	39	2		2	GNA14	9	80262686	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	60966557	80262686	60950745	84	8915										
AGTPBP1	23287	broad.mit.edu	37	chr9	88257814	88257814	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tctattgttcgtcccggttcTtgctggggttttagtttgtt	11	7	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:88257814T>C	uc011ltd.1	-	12	1263	c.1230A>G	c.(1228-1230)CAA>CAG	p.Q410Q	AGTPBP1_uc004aod.3_Silent_p.Q36Q|AGTPBP1_uc011ltc.1_Silent_p.Q308Q|AGTPBP1_uc010mqc.2_Silent_p.Q370Q|AGTPBP1_uc011lte.1_Silent_p.Q422Q	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	410					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GTCCCGGTTCTTGCTGGGGTT	0.294													0	0	0	0.006122	0	19	78										C	88257814	T	C	88257814	2	2	36	1	0	0	0	0	0	0	0	1	400	1606	56	5		5	AGTPBP1	9	88257814	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	7995128	88257814	52955617	85	8916										
KIF12	113220	broad.mit.edu	37	chr9	116856478	116856478	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tacctgagcctctcattctcTagcatgaactcctgtagcat	6	13	2	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:116856478T>C	uc004bif.2	-	10	1120	c.882A>G	c.(880-882)CTA>CTG	p.L294L	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	427	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TCTCATTCTCTAGCATGAACT	0.627													0	0	0	0.010504	0	19	90										C	116856478	T	C	116856478	2	2	36	1	0	0	0	0	0	0	0	1	8273	1509	53	5		5	KIF12	9	116856478	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	28598664	116856478	24356953	86	8917										
RALGDS	5900	broad.mit.edu	37	chr9	135977871	135977872	+	Frame_Shift_Ins	INS	-	-	CGCT													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caggcccttactcgctccagINScgcttgacaatggctgtgtt							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:135977871_135977872insCGCT	uc004cco.2	-	14	2020_2021	c.2000_2001insAGCG	c.(1999-2001)CGCfs	p.R667fs	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_5'Flank|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Frame_Shift_Ins_p.R655fs|RALGDS_uc004ccr.2_Frame_Shift_Ins_p.R666fs|RALGDS_uc011mcv.1_Frame_Shift_Ins_p.R638fs|RALGDS_uc004ccs.2_Frame_Shift_Ins_p.R612fs|RALGDS_uc011mcw.1_Frame_Shift_Ins_p.R738fs|RALGDS_uc004ccv.1_Frame_Shift_Ins_p.R436fs|RALGDS_uc004ccu.1_Frame_Shift_Ins_p.R436fs	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	667					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		ACTCGCTCCAGCGCTTGACAAT	0.515			T	CIITA	PMBL|Hodgkin Lymphona|													19	155	---	---								CGCT	135977872	-	CGCT	135977871	7	5	36	1	0	1	1	0	0	0	0	0	13016	958	34	0	763	0	RALGDS	9	135977871	Frame_Shift_Ins	INS	-	TCGA-CU-A0YR-01A-12D-A10S-08	19121393	135977871	5235560	87	8918										
PNPLA7	375775	broad.mit.edu	37	chr9	140444633	140444633	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tacatacctgtgggctgtcaTctttctcttcctccatggcc	7	14	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr9:140444633T>C	uc004cnf.2	-	1	354	c.17A>G	c.(16-18)GAT>GGT	p.D6G	PNPLA7_uc010ncj.1_Missense_Mutation_p.D6G|MRPL41_uc004cnh.3_5'Flank	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	6					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TGGGCTGTCATCTTTCTCTTC	0.547													0	0	0	0.013726	0	30	169										C	140444633	T	C	140444633	3	2	36	1	0	0	0	0	1	0	0	0	12170	1435	50	5	4151	5	PNPLA7	9	140444633	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	4466762	140444633	768798	88	8919										
CUBN	8029	broad.mit.edu	37	chr10	16911660	16911660	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtctgccggaaagacatcttCcagccttttgctgtctgaaa	9	11	3	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:16911660C>T	uc001ioo.2	-	59	9481	c.9429G>A	c.(9427-9429)TGG>TGA	p.W3143*	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Nonsense_Mutation_p.W499*	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3143	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGACATCTTCCAGCCTTTTG	0.448													0	0	0	0.01441	0	149	201										T	16911660	C	T	16911660	4	4	36	1	0	0	0	0	0	1	0	0	4051	856	30	1	1478	1	CUBN	10	16911660	Nonsense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08		16911660	118623087	89	8920										
CUBN	8029	broad.mit.edu	37	chr10	16911845	16911845	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ggagggaaccacatcaaaatCactgaacctgtgaaatgtac	9	9	2	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:16911845C>G	uc001ioo.2	-	59	9296	c.9244G>C	c.(9244-9246)GAT>CAT	p.D3082H	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.D438H	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3082	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACATCAAAATCACTGAACCTG	0.413													0	0	0	0.006999	0	38	57										G	16911845	C	G	16911845	3	3	36	1	0	0	0	0	1	0	0	0	4051	826	29	1	1663	1	CUBN	10	16911845	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	185	16911845	118622902	90	8921										
ARMC3	219681	broad.mit.edu	37	chr10	23290965	23290965	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctggtgacgagctgacggccAatgaattatgcaggctcggg	15	9	0	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:23290965A>G	uc001irm.3	+	12	1626	c.1543A>G	c.(1543-1545)AAT>GAT	p.N515D	ARMC3_uc010qcv.1_Missense_Mutation_p.N515D|ARMC3_uc010qcw.1_Missense_Mutation_p.N252D	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	515							binding				0						GCTGACGGCCAATGAATTATG	0.532													0	0	0	0.020292	0	13	23										G	23290965	A	G	23290965	3	3	36	1	0	0	0	0	1	0	0	0	952	130	5	5	1585	5	ARMC3	10	23290965	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	6379120	23290965	112243782	91	8922										
DLG5	9231	broad.mit.edu	37	chr10	79567584	79567584	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agctgtcaccaggcaggcccTtggccttcgtgaactcctca	10	15	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:79567584T>G	uc001jzk.2	-	25	4836	c.4766A>C	c.(4765-4767)AAG>ACG	p.K1589T	DLG5_uc001jzi.2_Missense_Mutation_p.K344T|DLG5_uc001jzj.2_Missense_Mutation_p.K1004T|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1589					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AGGCAGGCCCTTGGCCTTCGT	0.572													0	0	0	0.016522	0	20	129										G	79567584	T	G	79567584	3	3	36	1	0	0	0	0	1	0	0	0	4558	1609	56	5	1025	5	DLG5	10	79567584	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	56276619	79567584	55967163	92	8923										
POLR3A	11128	broad.mit.edu	37	chr10	79769683	79769683	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	catccttgccaaccagtattGaagcaatgatttggcaagcc	8	11	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:79769683G>A	uc001jzn.2	-	13	1803	c.1709C>T	c.(1708-1710)TCA>TTA	p.S570L		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	570					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AACCAGTATTGAAGCAATGAT	0.453													0	0	0	0.008871	0	21	50										A	79769683	G	A	79769683	3	1	36	1	0	0	0	0	1	0	0	0	12228	1294	45	1	2539	1	POLR3A	10	79769683	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	202099	79769683	55765064	93	8924										
ATRNL1	26033	broad.mit.edu	37	chr10	117607452	117607452	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agctgctgttctgactgtgtTtctttgtctaccacgaggat	10	9	3	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:117607452T>G	uc001lcg.2	+	28	4354	c.3968T>G	c.(3967-3969)TTT>TGT	p.F1323C	ATRNL1_uc010qsm.1_Missense_Mutation_p.F452C|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1323	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CTGACTGTGTTTCTTTGTCTA	0.473													0	0	0	0.013726	0	30	59										G	117607452	T	G	117607452	3	3	36	1	0	0	0	0	1	0	0	0	1207	1841	64	5	4078	5	ATRNL1	10	117607452	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	37837769	117607452	17927295	94	8925										
EIF3A	8661	broad.mit.edu	37	chr10	120801833	120801833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caaccctcgcctgggaccccGgtcatcatcagcattacgcc	8	18	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:120801833G>A	uc001ldu.2	-	19	3345	c.3199C>T	c.(3199-3201)CGG>TGG	p.R1067W	EIF3A_uc010qsu.1_Missense_Mutation_p.R1033W|EIF3A_uc009xzg.1_Missense_Mutation_p.R106W	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	1067	15.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CTGGGACCCCGGTCATCATCA	0.632													0	0	0	0.01441	0	63	311										A	120801833	G	A	120801833	3	1	36	1	0	0	0	0	1	0	0	0	5012	1115	39	2	965	2	EIF3A	10	120801833	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	3194381	120801833	14732914	95	8926										
CTBP2	1488	broad.mit.edu	37	chr10	126727575	126727575	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cacgctcttaccttcacaaaTtctgtccaatcgctgtctct	4	15	4	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:126727575T>A	uc009yak.2	-	3	336	c.49A>T	c.(49-51)ATT>TTT	p.I17F	CTBP2_uc009yal.2_Missense_Mutation_p.I17F|CTBP2_uc001lif.3_Missense_Mutation_p.I17F|CTBP2_uc001lih.3_Missense_Mutation_p.I17F	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	17					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCTTCACAAATTCTGTCCAAT	0.468													0	0	0	0.010504	0	20	96										A	126727575	T	A	126727575	3	1	36	1	0	0	0	0	1	0	0	0	3998	1493	52	5	3006	5	CTBP2	10	126727575	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	5925742	126727575	8807172	96	8927										
INPP5A	3632	broad.mit.edu	37	chr10	134579295	134579295	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agctcttggagtttgacaagGagttgtctgtctttaaggac	12	6	3	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:134579295G>C	uc001llp.2	+	12	1170	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	INPP5A_uc001llo.1_Missense_Mutation_p.E308Q|INPP5A_uc001llq.2_Missense_Mutation_p.E203Q	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	308					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		GTTTGACAAGGAGTTGTCTGT	0.502													0	0	0	0.00632	0	25	84										C	134579295	G	C	134579295	3	2	36	1	0	0	0	0	1	0	0	0	7754	1175	41	1	968	1	INPP5A	10	134579295	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	7851720	134579295	955452	97	8928										
SYCE1	93426	broad.mit.edu	37	chr10	135369108	135369108	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cctccacacgcacctctgccGcttctgctgctgttgttggc	9	17	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr10:135369108G>T	uc001lno.2	-	11	928	c.823C>A	c.(823-825)CGG>AGG	p.R275R	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Silent_p.R147R|SYCE1_uc009ybn.2_Silent_p.R275R|SYCE1_uc001lnn.2_Silent_p.R239R	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	275	Gln-rich.|Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CACCTctgccgcttctgctgc	0.373													1	0	2.17888e-05	0.006214	2.275e-05	9	22										T	135369108	G	T	135369108	2	4	36	1	0	0	0	0	0	0	0	1	15425	1086	38	4		4	SYCE1	10	135369108	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	789813	135369108	165639	98	8929										
OR51A4	401666	broad.mit.edu	37	chr11	4967692	4967692	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtgtaagacacagcaatgagAataaagtctaccataaggca	9	7	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:4967692A>G	uc010qys.1	-	1	639	c.639T>C	c.(637-639)ATT>ATC	p.I213I		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCAATGAGAATAAAGTCTA	0.428													0	0	0	0.021523	0	18	79										G	4967692	A	G	4967692	2	3	36	1	0	0	0	0	0	0	0	1	11087	242	9	5		5	OR51A4	11	4967692	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08		4967692	130038824	99	8930										
OR51A2	401667	broad.mit.edu	37	chr11	4976305	4976305	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtgtaagacacagcaatgagAataaagtctaccataaggca	9	7	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:4976305A>G	uc010qyt.1	-	1	639	c.639T>C	c.(637-639)ATT>ATC	p.I213I		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGCAATGAGAATAAAGTCTA	0.433													0	0	0	0.007413	0	14	16										G	4976305	A	G	4976305	2	3	36	1	0	0	0	0	0	0	0	1	11086	242	9	5		5	OR51A2	11	4976305	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	8613	4976305	130030211	100	8931										
NLRP14	338323	broad.mit.edu	37	chr11	7079645	7079645	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agtaaagcttatgagtgatgCcctgcaacatgcacaatgta	9	8	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:7079645C>T	uc001mfb.1	+	8	2920	c.2597C>T	c.(2596-2598)GCC>GTC	p.A866V		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	866					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATGAGTGATGCCCTGCAACAT	0.363													0	0	0	0.01441	0	49	58										T	7079645	C	T	7079645	3	4	36	1	0	0	0	0	1	0	0	0	10476	739	26	2	2623	2	NLRP14	11	7079645	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	2103340	7079645	127926871	101	8932										
COPB1	1315	broad.mit.edu	37	chr11	14490389	14490389	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tcaggctgtactgtcacattCctcttttcagattctttctg	6	11	6	1	rs139561241	byFrequency	TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:14490389C>A	uc001mli.2	-	16	2290	c.1983G>T	c.(1981-1983)AGG>AGT	p.R661S	COPB1_uc001mlg.2_Missense_Mutation_p.R661S|COPB1_uc001mlh.2_Missense_Mutation_p.R661S	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	661					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						CTGTCACATTCCTCTTTTCAG	0.378													1	0	1.66251e-12	0.01441	1.76176e-12	47	181										A	14490389	C	A	14490389	3	1	36	1	0	0	0	0	1	0	0	0	3728	854	30	3	906	3	COPB1	11	14490389	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	7410744	14490389	120516127	102	8933										
INSC	387755	broad.mit.edu	37	chr11	15212291	15212291	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tcagacaatatctacaccacAgagtccaccacagggaacct	6	14	2	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:15212291A>G	uc001mly.2	+	6	811	c.765A>G	c.(763-765)ACA>ACG	p.T255T	INSC_uc001mlz.2_Silent_p.T208T|INSC_uc001mma.2_Silent_p.T208T|INSC_uc010rcs.1_Silent_p.T243T|INSC_uc001mmb.2_Silent_p.T208T|INSC_uc001mmc.2_Silent_p.T208T	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	255					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TCTACACCACAGAGTCCACCA	0.507													0	0	0	0.01441	0	107	150										G	15212291	A	G	15212291	2	3	36	1	0	0	0	0	0	0	0	1	7764	175	7	5		5	INSC	11	15212291	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	721902	15212291	119794225	103	8934										
KCNA4	3739	broad.mit.edu	37	chr11	30033503	30033503	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gggacattgactggcctcttCaggcggcctcctgattgata	12	11	2	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:30033503C>T	uc001msk.2	-	2	1875	c.723G>A	c.(721-723)CTG>CTA	p.L241L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	241						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTGGCCTCTTCAGGCGGCCTC	0.498													0	0	0	0.01441	0	61	99										T	30033503	C	T	30033503	2	4	36	1	0	0	0	0	0	0	0	1	8005	813	29	1		1	KCNA4	11	30033503	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	14821212	30033503	104973013	104	8935										
MYBPC3	4607	broad.mit.edu	37	chr11	47359095	47359095	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gaagttcagccgcatccaccGgtagctcttcttcttcttgc	8	14	5	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:47359095G>C	uc001nfa.3	-	24	2504	c.2449C>G	c.(2449-2451)CGG>GGG	p.R817G	MYBPC3_uc010rhl.1_Intron	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	816	Fibronectin type-III 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		CGCATCCACCGGTAGCTCTTC	0.607													0	0	0	0.006214	0	9	43										C	47359095	G	C	47359095	3	2	36	1	0	0	0	0	1	0	0	0	10013	1115	39	4	1415	4	MYBPC3	11	47359095	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	17325592	47359095	87647421	105	8936										
KIAA1377	57562	broad.mit.edu	37	chr11	101833686	101833686	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gatgaaactagcaatatagaAaacaatgctgaaaacagtca	7	6	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:101833686A>T	uc001pgm.2	+	6	2190	c.1920A>T	c.(1918-1920)GAA>GAT	p.E640D	KIAA1377_uc001pgn.2_Missense_Mutation_p.E596D|KIAA1377_uc010run.1_Missense_Mutation_p.E441D|KIAA1377_uc009yxa.1_Missense_Mutation_p.E441D	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	640							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GCAATATAGAAAACAATGCTG	0.348													0	0	0	0.016723	0	13	78										T	101833686	A	T	101833686	3	4	36	1	0	0	0	0	1	0	0	0	8227	11	1	5	1942	5	KIAA1377	11	101833686	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	54474591	101833686	33172830	106	8937										
ATM	472	broad.mit.edu	37	chr11	108218083	108218083	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agtcagcagaacttgtacatAtagatctaggtaagtaataa	8	5	2	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:108218083A>T	uc001pkb.1	+	59	9047	c.8662A>T	c.(8662-8664)ATA>TTA	p.I2888L	ATM_uc009yxr.1_Missense_Mutation_p.I2888L|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.I1540L	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2888	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.I2888T(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ACTTGTACATATAGATCTAGG	0.303			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.01441	0	53	89										T	108218083	A	T	108218083	3	4	36	1	0	0	0	0	1	0	0	0	1109	449	16	5	8892	5	ATM	11	108218083	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	6384397	108218083	26788433	107	8938										
CBL	867	broad.mit.edu	37	chr11	119170369	119170369	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agatcgagaacctcatgagtCaggggtactcctaccaggac	11	11	2	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr11:119170369C>T	uc001pwe.2	+	16	2737	c.2599C>T	c.(2599-2601)CAG>TAG	p.Q867*		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	867	Interaction with CD2AP.|UBA.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CCTCATGAGTCAGGGGTACTC	0.532									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				0	0	0	0.01441	0	267	202										T	119170369	C	T	119170369	4	4	36	1	0	0	0	0	0	1	0	0	2700	827	29	1	2661	1	CBL	11	119170369	Nonsense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	10952286	119170369	15836147	108	8939										
CD27	939	broad.mit.edu	37	chr12	6554303	6554304	+	Missense_Mutation	DNP	CC	CC	AG													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggctgtgcgttctggggacCctggtggggctctcagctac							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:6554303_6554304CC>AG	uc001qod.2	+	1	253_254	c.42_43CC>AG	c.(40-45)ACCCTG>ACAGTG	p.L15V	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_Intron|CD27_uc001qoe.2_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	15					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0						TTCTGGGGACCCTGGTGGGGCT	0.629													0	0	0	0.004672	0	10	23										AG	6554304	CC	AG	6554303	3	1	36	1	0	0	0	0	1	0	0	0	2990	610	22	4	44	4	CD27	12	6554303	Missense_Mutation	DNP	CC	TCGA-CU-A0YR-01A-12D-A10S-08		6554303	127297592	109	8940										
SLCO1B3	28234	broad.mit.edu	37	chr12	21242857	21242857	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cacagaagagccttcttcggCttgaaggtagccctaatatt	9	10	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:21242857C>T	uc010sil.1	+	16	2129	c.2064C>T	c.(2062-2064)GGC>GGT	p.G688G	LST-3TM12_uc010sim.1_Silent_p.G627G|LST-3TM12_uc010sin.1_Silent_p.G580G			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCTTCTTCGGCTTGAAGGTAG	0.299													0	0	0	0.003163	0	15	48										T	21242857	C	T	21242857	2	4	36	1	0	0	0	0	0	0	0	1	14724	784	28	2		2	SLCO1B3	12	21242857	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	14688554	21242857	112609038	110	8941										
ABCC9	10060	broad.mit.edu	37	chr12	22028606	22028606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acctgttggaattcgaatatCtatattggataatgtagcta	8	5	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:22028606C>G	uc001rfi.1	-	15	2094	c.2074G>C	c.(2074-2076)GAT>CAT	p.D692H	ABCC9_uc001rfh.2_Missense_Mutation_p.D692H|ABCC9_uc001rfj.1_Missense_Mutation_p.D656H	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	692	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATTCGAATATCTATATTGGAT	0.308													0	0	0	0.016522	0	21	123										G	22028606	C	G	22028606	3	3	36	1	0	0	0	0	1	0	0	0	59	913	32	1	2813	1	ABCC9	12	22028606	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	785749	22028606	111823289	111	8942										
ITPR2	3709	broad.mit.edu	37	chr12	26492374	26492374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cacatggggtgtgtttgatcCgaggaagcccagtctctgct	13	10	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:26492374C>T	uc001rhg.2	-	57	8479	c.8062G>A	c.(8062-8064)GGA>AGA	p.G2688R		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2688	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GTGTTTGATCCGAGGAAGCCC	0.502													0	0	0	0.004482	0	7	76										T	26492374	C	T	26492374	3	4	36	1	0	0	0	0	1	0	0	0	7921	661	23	2	47	2	ITPR2	12	26492374	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	4463768	26492374	107359521	112	8943										
SLC4A8	9498	broad.mit.edu	37	chr12	51856143	51856143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agagcgagatgatctcctggCggggattgatgagttcctag	15	7	1	5			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:51856143C>T	uc001rys.1	+	10	1329	c.1151C>T	c.(1150-1152)GCG>GTG	p.A384V	SLC4A8_uc010sni.1_Missense_Mutation_p.A331V|SLC4A8_uc001rym.2_Missense_Mutation_p.A331V|SLC4A8_uc001ryn.2_Missense_Mutation_p.A331V|SLC4A8_uc001ryo.2_Missense_Mutation_p.A331V|SLC4A8_uc001ryp.1_3'UTR|SLC4A8_uc010snj.1_Missense_Mutation_p.A411V|SLC4A8_uc001ryq.3_Missense_Mutation_p.A384V|SLC4A8_uc001ryr.2_Missense_Mutation_p.A384V|SLC4A8_uc010snk.1_Missense_Mutation_p.A331V	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	384	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		GATCTCCTGGCGGGGATTGAT	0.458													0	0	0	0.013726	0	33	142										T	51856143	C	T	51856143	3	4	36	1	0	0	0	0	1	0	0	0	14659	768	27	2	1189	2	SLC4A8	12	51856143	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	25363769	51856143	81995752	113	8944										
PAN2	9924	broad.mit.edu	37	chr12	56720613	56720613	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagaggtgcacacagccctcAgaatccccaaaggccagagc	10	15	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:56720613A>G	uc001skx.2	-	7	1423	c.1050T>C	c.(1048-1050)TCT>TCC	p.S350S	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Silent_p.S350S|PAN2_uc001sky.2_Silent_p.S350S	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	350					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CACAGCCCTCAGAATCCCCAA	0.557													0	0	0	0.01441	0	165	205										G	56720613	A	G	56720613	2	3	36	1	0	0	0	0	0	0	0	1	11414	175	7	5		5	PAN2	12	56720613	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	4864470	56720613	77131282	114	8945										
LRIG3	121227	broad.mit.edu	37	chr12	59271541	59271541	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctttggtccagttcagtttaGggggagggcttcctccagca	13	10	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:59271541G>C	uc001sqr.2	-	15	2423	c.2177C>G	c.(2176-2178)CCT>CGT	p.P726R	LRIG3_uc009zqh.2_Missense_Mutation_p.P666R|LRIG3_uc010ssh.1_RNA	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like	726	Ig-like C2-type 3.					integral to membrane				skin(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;1.17e-18)			GTTCAGTTTAGGGGGAGGGCT	0.488													0	0	0	0.012213	0	33	119										C	59271541	G	C	59271541	3	2	36	1	0	0	0	0	1	0	0	0	8946	1000	35	4	1202	4	LRIG3	12	59271541	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	2550928	59271541	74580354	115	8946										
XPOT	11260	broad.mit.edu	37	chr12	64815090	64815090	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agtcattgatagttagttggAgtaaattaattaagaatggg	11	1	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:64815090A>G	uc001ssb.2	+	9	1345	c.919A>G	c.(919-921)AGT>GGT	p.S307G	XPOT_uc009zqm.1_Missense_Mutation_p.S217G	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	307	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		AGTTAGTTGGAGTAAATTAAT	0.373													0	0	0	0.013114	0	47	166										G	64815090	A	G	64815090	3	3	36	1	0	0	0	0	1	0	0	0	17447	304	11	5	949	5	XPOT	12	64815090	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	5543549	64815090	69036805	116	8947										
CNOT2	4848	broad.mit.edu	37	chr12	70672040	70672040	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	atggacatacattatctgagAaaagaaactaccaggtaaga	8	6	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:70672040A>T	uc001svv.2	+	2	613	c.34A>T	c.(34-36)AAA>TAA	p.K12*	CNOT2_uc009zro.2_Nonsense_Mutation_p.K12*|CNOT2_uc009zrp.2_5'UTR|CNOT2_uc009zrq.2_Nonsense_Mutation_p.K12*	NM_014515	NP_055330	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	12					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			ATTATCTGAGAAAAGAAACTA	0.398													0	0	0	0.00623	0	38	105										T	70672040	A	T	70672040	4	4	36	1	0	0	0	0	0	1	0	0	3619	247	9	5	36	5	CNOT2	12	70672040	Nonsense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	5856950	70672040	63179855	117	8948										
BBS10	79738	broad.mit.edu	37	chr12	76742124	76742126	+	In_Frame_Del	DEL	CAT	CAT	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttcacagaccctgcagcggcCatagaacttaacatatctgg							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:76742124_76742126delCAT	uc001syd.1	-	1	97_99	c.13_15delATG	c.(13-15)ATGdel	p.M5del		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	5					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						CTGCAGCGGCCATAGAACTTAAC	0.611									Bardet-Biedl_syndrome		OREG0022001	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						10	18	---	---								-	76742126	CAT	-	76742124	7	5	36	1	0	1	0	1	0	0	0	0	1336	594	21	0	2164	0	BBS10	12	76742124	In_Frame_Del	DEL	CAT	TCGA-CU-A0YR-01A-12D-A10S-08	6070084	76742124	57109771	118	8949										
SLC5A8	160728	broad.mit.edu	37	chr12	101595946	101595946	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caactctaaaatgtaccttgAttcaaagccagggcaggggc	10	10	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:101595946A>T	uc001thz.3	-	3	855	c.465T>A	c.(463-465)AAT>AAA	p.N155K		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	155	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						ATGTACCTTGATTCAAAGCCA	0.388													0	0	0	0.012213	0	29	47										T	101595946	A	T	101595946	3	4	36	1	0	0	0	0	1	0	0	0	14671	330	12	5	1419	5	SLC5A8	12	101595946	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	24853822	101595946	32255949	119	8950										
PRDM4	11108	broad.mit.edu	37	chr12	108140192	108140192	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	agggataggcgcggtcacacAgagtacaccctgtagatggc	14	10	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:108140192A>G	uc001tmp.2	-	6	1573	c.1136T>C	c.(1135-1137)CTG>CCG	p.L379P	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	379					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCGGTCACACAGAGTACACCC	0.428													0	0	0	0.014758	0	3	104										G	108140192	A	G	108140192	3	3	36	1	0	0	0	0	1	0	0	0	12459	188	7	5	1297	5	PRDM4	12	108140192	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	6544246	108140192	25711703	120	8951										
NAA25	80018	broad.mit.edu	37	chr12	112499125	112499125	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gctgcagagctctgatgtcaGcaggcagtgccagcttatcc	12	12	2	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:112499125G>A	uc001ttm.2	-	12	1237	c.1217C>T	c.(1216-1218)GCT>GTT	p.A406V	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.A378V|NAA25_uc009zwa.1_Missense_Mutation_p.A406V	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	406						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						TCTGATGTCAGCAGGCAGTGC	0.458													0	0	0	0.019004	0	33	36										A	112499125	G	A	112499125	3	1	36	1	0	0	0	0	1	0	0	0	10121	971	34	2	1753	2	NAA25	12	112499125	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	4358933	112499125	21352770	121	8952										
GPR133	283383	broad.mit.edu	37	chr12	131487771	131487771	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctcatcgacactattgacacCgtcatgggccatgtatcctc	7	14	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:131487771C>T	uc001uit.3	+	10	1627	c.1068C>T	c.(1066-1068)ACC>ACT	p.T356T	GPR133_uc010tbm.1_Silent_p.T388T	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	356	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CTATTGACACCGTCATGGGCC	0.602													0	0	0	0.01441	0	52	167										T	131487771	C	T	131487771	2	4	36	1	0	0	0	0	0	0	0	1	6643	639	23	2		2	GPR133	12	131487771	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	18988646	131487771	2364124	122	8953										
ANKLE2	23141	broad.mit.edu	37	chr12	133327289	133327289	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aggagacagtggtaaggacgTtttgcttggagaagggaaat	16	3	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr12:133327289T>C	uc001ukx.2	-	3	854	c.787A>G	c.(787-789)ACG>GCG	p.T263A	ANKLE2_uc001uky.3_Missense_Mutation_p.T201A	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	263						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GGTAAGGACGTTTTGCTTGGA	0.423													0	0	0	0.01441	0	46	40										C	133327289	T	C	133327289	3	2	36	1	0	0	0	0	1	0	0	0	633	1725	60	5	2073	5	ANKLE2	12	133327289	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	1839518	133327289	524606	123	8954										
NBEA	26960	broad.mit.edu	37	chr13	35923273	35923273	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gccatgctatgaaggaccatAtagtccgtgttgcaaatgaa	10	8	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr13:35923273A>G	uc001uvb.2	+	37	6138	c.5932A>G	c.(5932-5934)ATA>GTA	p.I1978V	NBEA_uc010abi.2_Missense_Mutation_p.I634V	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1978						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GAAGGACCATATAGTCCGTGT	0.348													0	0	0	0.010729	0	10	51										G	35923273	A	G	35923273	3	3	36	1	0	0	0	0	1	0	0	0	10187	449	16	5	6078	5	NBEA	13	35923273	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08		35923273	79246605	124	8955										
TRPC4	7223	broad.mit.edu	37	chr13	38320157	38320157	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tatgagactattgtcatctcGgtaattaagaatgatttcca	7	6	2	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr13:38320157G>A	uc001uws.2	-	3	1049	c.814C>T	c.(814-816)CGA>TGA	p.R272*	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Nonsense_Mutation_p.R272*|TRPC4_uc010tey.1_Nonsense_Mutation_p.R272*|TRPC4_uc010abw.2_Intron|TRPC4_uc010abx.2_Nonsense_Mutation_p.R272*|TRPC4_uc010aby.2_Nonsense_Mutation_p.R272*	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	272	Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTGTCATCTCGGTAATTAAGA	0.418													0	0	0	0.01441	0	109	281										A	38320157	G	A	38320157	4	1	36	1	0	0	0	0	0	1	0	0	16577	1124	39	2	2170	2	TRPC4	13	38320157	Nonsense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	2396884	38320157	76849721	125	8956										
CDADC1	81602	broad.mit.edu	37	chr13	49833659	49833660	+	Splice_Site	INS	-	-	GTAA													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tttgaaaatgattgtaaatgINSgtaagtgcagaaaagggttt							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr13:49833659_49833660insGTAA	uc001vcu.2	+	4	506	c.430_splice	c.e4+1	p.A144_splice	CDADC1_uc001vcs.1_Splice_Site|CDADC1_uc001vct.1_Splice_Site_p.A26_splice|CDADC1_uc010tgk.1_Intron|CDADC1_uc001vcv.2_Splice_Site	NM_030911	NP_112173	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1								hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		GATTGTAAATGGTAAGTGCAGA	0.272																		16	156	---	---								GTAA	49833660	-	GTAA	49833659	8	5	36	1	0	1	1	0	0	0	1	0	3053	1362	47	0	444	0	CDADC1	13	49833659	Splice_Site	INS	-	TCGA-CU-A0YR-01A-12D-A10S-08	11513502	49833659	65336219	126	8957										
SCEL	8796	broad.mit.edu	37	chr13	78178541	78178541	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ggatcctgaaacaaataaaaAtattacgaggtaagacattt	7	5	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr13:78178541A>G	uc001vki.2	+	19	1318	c.1148A>G	c.(1147-1149)AAT>AGT	p.N383S	SCEL_uc001vkj.2_Missense_Mutation_p.N363S|SCEL_uc010thx.1_Intron	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	383	16 X approximate tandem repeats.|7.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ACAAATAAAAATATTACGAGG	0.333													0	0	0	0.01441	0	83	182										G	78178541	A	G	78178541	3	3	36	1	0	0	0	0	1	0	0	0	13888	101	4	5	1218	5	SCEL	13	78178541	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	28344882	78178541	36991337	127	8958										
LRP10	26020	broad.mit.edu	37	chr14	23344694	23344694	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ggttgcagctcagaccccttCcctggcctgaccccaagacc	9	18	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr14:23344694C>T	uc001whd.2	+	5	1090	c.537C>T	c.(535-537)TTC>TTT	p.F179F	LRP10_uc001whe.2_Silent_p.F55F	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	179	Extracellular (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		CAGACCCCTTCCCTGGCCTGA	0.582													0	0	0	0.01441	0	71	191										T	23344694	C	T	23344694	2	4	36	1	0	0	0	0	0	0	0	1	8952	854	30	1		1	LRP10	14	23344694	Silent	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08		23344694	84004846	128	8959										
MIPOL1	145282	broad.mit.edu	37	chr14	37838794	37838795	+	Missense_Mutation	DNP	CT	CT	GA													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagcaaacaacatgagacatCtgactgctgaaaacaatcaa							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr14:37838794_37838795CT>GA	uc001wuc.2	+	11	1404_1405	c.901_902CT>GA	c.(901-903)CTG>GAG	p.L301E	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Missense_Mutation_p.L270E|MIPOL1_uc001wud.2_Missense_Mutation_p.L301E|MIPOL1_uc010ams.2_Missense_Mutation_p.L301E|MIPOL1_uc001wue.2_Missense_Mutation_p.L270E|MIPOL1_uc010amt.2_Missense_Mutation_p.L120E	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	301	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		CATGAGACATCTGACTGCTGAA	0.46													0	0	0	0.004672	0	27	52										GA	37838795	CT	GA	37838794	3	3	36	1	0	0	0	0	1	0	0	0	9593	912	32	1	931	1	MIPOL1	14	37838794	Missense_Mutation	DNP	CT	TCGA-CU-A0YR-01A-12D-A10S-08	14494100	37838794	69510746	129	8960										
FSIP1	161835	broad.mit.edu	37	chr15	39910371	39910371	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ttctgaagaaagtttaatgaTggatttttgtttaagtatgc	9	2	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr15:39910371T>C	uc001zki.2	-	11	1482	c.1264A>G	c.(1264-1266)ATC>GTC	p.I422V		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	422										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		AGTTTAATGATGGATTTTTGT	0.368													0	0	0	0.01441	0	53	65										C	39910371	T	C	39910371	3	2	36	1	0	0	0	0	1	0	0	0	6074	1464	51	5	489	5	FSIP1	15	39910371	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08		39910371	62621021	130	8961										
IGF1R	3480	broad.mit.edu	37	chr15	99250976	99250976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgttccgagtggctggcctcGagagcctcggagacctcttc	13	13	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr15:99250976G>A	uc002bul.2	+	2	330	c.280G>A	c.(280-282)GAG>AAG	p.E94K	IGF1R_uc010urq.1_Missense_Mutation_p.E94K|IGF1R_uc010bon.2_Missense_Mutation_p.E94K	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	94					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GGCTGGCCTCGAGAGCCTCGG	0.577													0	0	0	0.001984	0	7	62										A	99250976	G	A	99250976	3	1	36	1	0	0	0	0	1	0	0	0	7571	1059	37	1	286	1	IGF1R	15	99250976	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	59340605	99250976	3280416	131	8962										
NME4	4833	broad.mit.edu	37	chr16	449378	449378	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ccttacctcaatgccacccaGgcaccagagagcgtccttgc	8	17	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:449378G>A	uc002cgz.2	+	3	257	c.226_splice	c.e3-1	p.A76_splice	NME4_uc002cgy.2_Splice_Site_p.A6_splice|NME4_uc002cha.2_Splice_Site|DECR2_uc002chb.2_5'Flank|DECR2_uc002chc.2_5'Flank|DECR2_uc010bqv.2_5'Flank|DECR2_uc002chd.2_5'Flank	NM_005009	NP_005000	O00746	NDKM_HUMAN	nucleoside diphosphate kinase 4 precursor						CTP biosynthetic process|GTP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|UTP biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	ATP binding|metal ion binding|nucleoside diphosphate kinase activity				0		Hepatocellular(16;0.00015)				ATGCCACCCAGGCACCAGAGA	0.607													0	0	0	0.01441	0	130	282										A	449378	G	A	449378	5	1	36	1	0	0	0	0	0	0	1	0	10493	1014	35	2	235	2	NME4	16	449378	Splice_Site	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08		449378	89905375	132	8963										
C16orf54	283897	broad.mit.edu	37	chr16	29756070	29756070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gccacaccagggtgggtgcaCggtggctggggtctgggcgg	21	10	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:29756070C>T	uc002dtp.2	-	2	312	c.203G>A	c.(202-204)CGT>CAT	p.R68H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002dtq.1_5'Flank	NM_175900	NP_787096	Q6UWD8	CP054_HUMAN	hypothetical protein LOC283897	68						integral to membrane					0						GGTGGGTGCACGGTGGCTGGG	0.677													0	0	0	0.009096	0	4	3										T	29756070	C	T	29756070	3	4	36	1	0	0	0	0	1	0	0	0	1819	536	19	2	475	2	C16orf54	16	29756070	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	29306692	29756070	60598683	133	8964										
ACD	65057	broad.mit.edu	37	chr16	67692470	67692470	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cacctcacctgaggaactggGtgaggaaggaggagaggcta	16	8	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:67692470G>T	uc002etq.3	-	9	1412	c.1075C>A	c.(1075-1077)CCC>ACC	p.P359T	ACD_uc002etp.3_Missense_Mutation_p.P356T|ACD_uc002etr.3_Missense_Mutation_p.P356T|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	359	Ser-rich.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GAGGAACTGGGTGAGGAAGGA	0.617													1	0	3.28513e-13	0.021523	3.51624e-13	23	107										T	67692470	G	T	67692470	3	4	36	1	0	0	0	0	1	0	0	0	135	1261	44	4	575	4	ACD	16	67692470	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	37936400	67692470	22662283	134	8965										
CENPT	80152	broad.mit.edu	37	chr16	67863976	67863976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cctctcctgccagaaactggGctggtttcccagggcctgag	12	14	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:67863976G>A	uc002eun.3	-	12	1427	c.878C>T	c.(877-879)GCC>GTC	p.A293V	CENPT_uc002eum.3_Missense_Mutation_p.A293V|CENPT_uc010vkc.1_Missense_Mutation_p.A51V|CENPT_uc010vkd.1_Missense_Mutation_p.A46V|CENPT_uc010vke.1_3'UTR	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	293					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CAGAAACTGGGCTGGTTTCCC	0.567													0	0	0	0.009535	0	32	36										A	67863976	G	A	67863976	3	1	36	1	0	0	0	0	1	0	0	0	3242	1203	42	2	827	2	CENPT	16	67863976	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	171506	67863976	22490777	135	8966										
VAC14	55697	broad.mit.edu	37	chr16	70834774	70834774	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gcgcgcacgatgttaggcgtGagcggcgcgaaatccttctc	14	12	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:70834774G>T	uc002ezm.2	-	1	288	c.30C>A	c.(28-30)CTC>CTA	p.L10L	VAC14_uc010cfw.2_5'UTR|VAC14_uc002ezn.2_5'UTR	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	10	HEAT 1.				interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				TGTTAGGCGTGAGCGGCGCGA	0.522													1	0	0.00244969	0.020292	0.0025207	13	109										T	70834774	G	T	70834774	2	4	36	1	0	0	0	0	0	0	0	1	17108	1277	45	3		3	VAC14	16	70834774	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	2970798	70834774	19519979	136	8967										
FTSJD1	55783	broad.mit.edu	37	chr16	71319027	71319027	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caaaagagccaccgtttccaAgagtggtcagagcagtgaca	11	10	1	4			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:71319027A>C	uc010cga.2	-	3	1203	c.797T>G	c.(796-798)CTT>CGT	p.L266R	FTSJD1_uc002ezy.3_Missense_Mutation_p.L266R|FTSJD1_uc002ezz.3_Missense_Mutation_p.L266R	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	266						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						ACCGTTTCCAAGAGTGGTCAG	0.398													0	0	0	0.008361	0	29	60										C	71319027	A	C	71319027	3	2	36	1	0	0	0	0	1	0	0	0	6090	72	3	5	1519	5	FTSJD1	16	71319027	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	484253	71319027	19035726	137	8968										
PMFBP1	83449	broad.mit.edu	37	chr16	72205093	72205101	+	Splice_Site	DEL	TACCTCATC	TACCTCATC	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgtagaggagttaggagcctTacctcatctttcatttcctt							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr16:72205093_72205101delTACCTCATC	uc002fcc.3	-	2	184	c.12_splice	c.e2+1	p.E4_splice	PMFBP1_uc002fcd.2_Splice_Site_p.E4_splice|PMFBP1_uc002fce.2_Splice_Site|PMFBP1_uc002fcf.2_Splice_Site	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1											ovary(2)	2		Ovarian(137;0.179)				TTAGGAGCCTTACCTCATCTTTCATTTCC	0.33																		14	179	---	---								-	72205101	TACCTCATC	-	72205093	8	5	36	1	0	1	0	1	0	0	1	0	12134	1769	61	0		0	PMFBP1	16	72205093	Splice_Site	DEL	TACCTCATC	TCGA-CU-A0YR-01A-12D-A10S-08	886066	72205093	18149660	138	8969										
ZZEF1	23140	broad.mit.edu	37	chr17	3920781	3920781	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggcacgtggctaggccactCggcgagcagggatgcaagca	16	11	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:3920781C>T	uc002fxe.2	-	48	7949	c.7885G>A	c.(7885-7887)GAG>AAG	p.E2629K	ZZEF1_uc002fxg.1_5'UTR	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2629							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTAGGCCACTCGGCGAGCAGG	0.577													0	0	0	0.012213	0	21	44										T	3920781	C	T	3920781	3	4	36	1	0	0	0	0	1	0	0	0	18252	893	31	1	1032	1	ZZEF1	17	3920781	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08		3920781	77274429	139	8970										
PER1	5187	broad.mit.edu	37	chr17	8046123	8046123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtcactggagccggaaagtgCgtcctgattggaggactcag	15	9	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:8046123C>T	uc002gkd.2	-	20	3341	c.3103G>A	c.(3103-3105)GCA>ACA	p.A1035T	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1035	Ser-rich.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CCGGAAAGTGCGTCCTGATTG	0.647			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					0	0	0	0.004482	0	8	26										T	8046123	C	T	8046123	3	4	36	1	0	0	0	0	1	0	0	0	11729	768	27	2	785	2	PER1	17	8046123	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	4125342	8046123	73149087	140	8971										
TOP3A	7156	broad.mit.edu	37	chr17	18196135	18196135	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtttaagtctctgggaaaaaTgtttgtttctgttcggggat	12	4	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:18196135T>C	uc002gsx.1	-	11	1334	c.1105A>G	c.(1105-1107)ATT>GTT	p.I369V	TOP3A_uc010cpz.1_5'Flank|TOP3A_uc010vxr.1_Intron|TOP3A_uc002gsw.1_Intron|TOP3A_uc010vxs.1_Missense_Mutation_p.I267V	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	369					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						CTGGGAAAAATGTTTGTTTCT	0.483													0	0	0	0.01441	0	48	86										C	18196135	T	C	18196135	3	2	36	1	0	0	0	0	1	0	0	0	16364	1464	51	5	1936	5	TOP3A	17	18196135	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	10150012	18196135	62999075	141	8972										
EFCAB5	374786	broad.mit.edu	37	chr17	28405458	28405458	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gctgcaccaaatccaatgtgCtgcagagacaagtggggtgt	13	9	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:28405458C>G	uc002het.2	+	15	3155	c.2963C>G	c.(2962-2964)GCT>GGT	p.A988G	EFCAB5_uc010cse.2_Missense_Mutation_p.A743G|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	988							calcium ion binding			ovary(1)|skin(1)	2						ATCCAATGTGCTGCAGAGACA	0.473													0	0	0	0.010504	0	22	54										G	28405458	C	G	28405458	3	3	36	1	0	0	0	0	1	0	0	0	4938	797	28	4	3188	4	EFCAB5	17	28405458	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	10209323	28405458	52789752	142	8973										
EVI2B	2124	broad.mit.edu	37	chr17	29631980	29631980	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	acaatgatgattatagctacCaacatagaagtcagaagtac	7	7	1	4			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:29631980C>G	uc002hgk.2	-	2	803	c.648G>C	c.(646-648)TTG>TTC	p.L216F	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2B_uc010csq.2_Missense_Mutation_p.L231F	NM_006495	NP_006486	P34910	EVI2B_HUMAN	ecotropic viral integration site 2B precursor	216	Helical; (Potential).					cytoplasm|integral to plasma membrane				ovary(2)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;6.88e-13)|Epithelial(4;8.95e-12)|OV - Ovarian serous cystadenocarcinoma(4;1.01e-11)|GBM - Glioblastoma multiforme(4;0.184)		TTATAGCTACCAACATAGAAG	0.343													0	0	0	0.01441	0	53	161										G	29631980	C	G	29631980	3	3	36	1	0	0	0	0	1	0	0	0	5288	593	21	4	702	4	EVI2B	17	29631980	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	1226522	29631980	51563230	143	8974										
PLEKHM1	9842	broad.mit.edu	37	chr17	43545795	43545795	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	catcttgagttccagaggctGcctgggcaggaaggggctct	15	10	2	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:43545795G>C	uc002ija.2	-	5	1258	c.1088C>G	c.(1087-1089)GCA>GGA	p.A363G	PLEKHM1_uc010wjm.1_Missense_Mutation_p.A335G|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Missense_Mutation_p.A312G	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	363					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					TCCAGAGGCTGCCTGGGCAGG	0.642													0	0	0	0.006214	0	8	43										C	43545795	G	C	43545795	3	2	36	1	0	0	0	0	1	0	0	0	12080	1319	46	4	2114	4	PLEKHM1	17	43545795	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	13913815	43545795	37649415	144	8975										
KPNB1	3837	broad.mit.edu	37	chr17	45750422	45750422	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caacctgaggagttctgcatAtgaatctctgatggaaattg	10	7	2	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:45750422A>G	uc002ilt.1	+	13	1922	c.1586A>G	c.(1585-1587)TAT>TGT	p.Y529C	KPNB1_uc010wkw.1_Missense_Mutation_p.Y384C|KPNB1_uc010wkx.1_Missense_Mutation_p.Y313C	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	529					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGTTCTGCATATGAATCTCTG	0.423													0	0	0	0.00623	0	39	67										G	45750422	A	G	45750422	3	3	36	1	0	0	0	0	1	0	0	0	8435	449	16	5	1636	5	KPNB1	17	45750422	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	2204627	45750422	35444788	145	8976										
HOXB4	3214	broad.mit.edu	37	chr17	46654171	46654171	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gagcggatcttggtgttgggCaacttgtggtcttttttcca	13	7	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:46654171C>A	uc002inp.2	-	2	731	c.669G>T	c.(667-669)TTG>TTT	p.L223F	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	223						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGTGTTGGGCAACTTGTGGT	0.677													1	0	9.65139e-37	0.01441	1.05423e-36	66	121										A	46654171	C	A	46654171	3	1	36	1	0	0	0	0	1	0	0	0	7303	709	25	4	90	4	HOXB4	17	46654171	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	903749	46654171	34541039	146	8977										
HEATR6	63897	broad.mit.edu	37	chr17	58145064	58145064	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tctccttgctggattttcttTggttttactttggatttttt	7	6	2	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:58145064T>C	uc002iyk.1	-	8	986	c.969A>G	c.(967-969)CCA>CCG	p.P323P	HEATR6_uc010ddk.1_5'Flank|HEATR6_uc010wos.1_Silent_p.P155P	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	323	Poly-Lys.						binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GGATTTTCTTTGGTTTTACTT	0.413													0	0	0	0.01441	0	43	99										C	58145064	T	C	58145064	2	2	36	1	0	0	0	0	0	0	0	1	7033	1799	63	5		5	HEATR6	17	58145064	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	11490893	58145064	23050146	147	8978										
CDC42EP4	23580	broad.mit.edu	37	chr17	71281971	71281971	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cactcctccttgtccatgatGctgaggacgtcacccagcat	8	15	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr17:71281971G>A	uc002jjn.2	-	2	816	c.669C>T	c.(667-669)AGC>AGT	p.S223S	CDC42EP4_uc002jjo.2_Silent_p.S223S|CDC42EP4_uc002jjp.1_Silent_p.S153S	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	223					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			TGTCCATGATGCTGAGGACGT	0.657													0	0	0	0.01441	0	70	103										A	71281971	G	A	71281971	2	1	36	1	0	0	0	0	0	0	0	1	3078	1310	46	2		2	CDC42EP4	17	71281971	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	13136907	71281971	9913239	148	8979										
LAMA3	3909	broad.mit.edu	37	chr18	21437864	21437877	+	Frame_Shift_Del	DEL	GCTTTCCTGAGTGT	GCTTTCCTGAGTGT	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	atgtgcttccgggttttaccGctttcctgagtgtgttccct							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr18:21437864_21437877delGCTTTCCTGAGTGT	uc002kuq.2	+	33	4279_4292	c.4193_4206delGCTTTCCTGAGTGT	c.(4192-4206)CGCTTTCCTGAGTGTfs	p.R1398fs	LAMA3_uc002kur.2_Frame_Shift_Del_p.R1398fs	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1398_1402	Domain III B.|Laminin EGF-like 11.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGTTTTACCGCTTTCCTGAGTGTGTTCCCTGCA	0.519																		53	105	---	---								-	21437877	GCTTTCCTGAGTGT	-	21437864	7	5	36	1	0	1	0	1	0	0	0	0	8607	1087	38	0	4323	0	LAMA3	18	21437864	Frame_Shift_Del	DEL	GCTTTCCTGAGTGT	TCGA-CU-A0YR-01A-12D-A10S-08		21437864	56639384	149	8980										
LAMA3	3909	broad.mit.edu	37	chr18	21437915	21437915	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cagagatgggactgagccagGagtgtgtgacccagggaccg	17	9	0	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr18:21437915G>A	uc002kuq.2	+	33	4330	c.4244G>A	c.(4243-4245)GGA>GAA	p.G1415E	LAMA3_uc002kur.2_Missense_Mutation_p.G1415E	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1415	Laminin EGF-like 12.|Domain III B.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGAGCCAGGAGTGTGTGAC	0.562													0	0	0	0.01441	0	57	71										A	21437915	G	A	21437915	3	1	36	1	0	0	0	0	1	0	0	0	8607	1174	41	1	4374	1	LAMA3	18	21437915	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	51	21437915	56639333	150	8981										
ME2	4200	broad.mit.edu	37	chr18	48450474	48450480	+	Frame_Shift_Del	DEL	AAAGCAA	AAAGCAA	-													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	atctcaaaatttagggacggAaagcaaaaatagatagttat							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr18:48450474_48450480delAAAGCAA	uc002ley.2	+	11	1319_1325	c.1063_1069delAAAGCAA	c.(1063-1071)AAAGCAAAAfs	p.K355fs	ME2_uc010dpd.2_Frame_Shift_Del_p.K355fs	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	355_357					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	TTAGGGACGGAAAGCAAAAATAGATAG	0.314																		38	60	---	---								-	48450480	AAAGCAA	-	48450474	7	5	36	1	0	1	0	1	0	0	0	0	9418	247	9	0	1101	0	ME2	18	48450474	Frame_Shift_Del	DEL	AAAGCAA	TCGA-CU-A0YR-01A-12D-A10S-08	27012559	48450474	29626774	151	8982										
ZNF317	57693	broad.mit.edu	37	chr19	9271246	9271247	+	Missense_Mutation	DNP	GA	GA	TT													0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gcgagaggccttacaagtgtGatcagtgcgggaaggcttac							TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:9271246_9271247GA>TT	uc002mku.2	+	7	1200_1201	c.925_926GA>TT	c.(925-927)GAT>TTT	p.D309F	ZNF317_uc002mkv.2_Missense_Mutation_p.D168F|ZNF317_uc002mkw.2_Missense_Mutation_p.D277F|ZNF317_uc002mkx.2_Missense_Mutation_p.D224F|ZNF317_uc002mky.2_Missense_Mutation_p.D192F	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	309	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTACAAGTGTGATCAGTGCGGG	0.574													0	0	0	0.004672	0	38	77										TT	9271247	GA	TT	9271246	3	4	36	1	0	0	0	0	1	0	0	0	17832	1290	45	3	947	3	ZNF317	19	9271246	Missense_Mutation	DNP	GA	TCGA-CU-A0YR-01A-12D-A10S-08		9271246	49857737	152	8983										
TYK2	7297	broad.mit.edu	37	chr19	10475635	10475635	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cacagtggctcccgcggcctGtctgccggctggccgactgc	14	17	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:10475635G>A	uc002moc.3	-	8	1479	c.1101C>T	c.(1099-1101)GAC>GAT	p.D367D	TYK2_uc010dxe.2_Silent_p.D182D|TYK2_uc002mod.2_Silent_p.D367D	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	367	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCCGCGGCCTGTCTGCCGGCT	0.617													0	0	0	0.014323	0	21	50										A	10475635	G	A	10475635	2	1	36	1	0	0	0	0	0	0	0	1	16807	1368	48	2		2	TYK2	19	10475635	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	1204389	10475635	48653348	153	8984										
COMP	1311	broad.mit.edu	37	chr19	18896789	18896789	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ccgtactgtccgcgtcctccTggccggggttaggcaccagg	14	15	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:18896789T>A	uc002nke.2	-	13	1511	c.1475A>T	c.(1474-1476)CAG>CTG	p.Q492L	COMP_uc002nkd.2_Missense_Mutation_p.Q459L|COMP_uc010xqj.1_Missense_Mutation_p.Q439L	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	492	TSP type-3 7.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						CGCGTCCTCCTGGCCGGGGTT	0.711													0	0	0	0.008871	0	17	14										A	18896789	T	A	18896789	3	1	36	1	0	0	0	0	1	0	0	0	3724	1580	55	5	826	5	COMP	19	18896789	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	8421154	18896789	40232194	154	8985										
ZNF253	56242	broad.mit.edu	37	chr19	20003518	20003518	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tagtgaagaatgtgacagatCttttaaatgttcctccactt	7	7	1	4			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:20003518C>G	uc002noj.2	+	4	1554	c.1462C>G	c.(1462-1464)CTT>GTT	p.L488V	ZNF253_uc002nok.2_Missense_Mutation_p.L412V|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	488					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTGACAGATCTTTTAAATGT	0.358													0	0	0	0.004672	0	3	121										G	20003518	C	G	20003518	3	3	36	1	0	0	0	0	1	0	0	0	17794	913	32	1	1476	1	ZNF253	19	20003518	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	1106729	20003518	39125465	155	8986										
ZBTB32	27033	broad.mit.edu	37	chr19	36205902	36205902	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aaagccagatccaggcctgaAgaaacatcaggaggagccag	12	10	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:36205902A>C	uc002oay.2	+	2	584	c.374A>C	c.(373-375)AAG>ACG	p.K125T	ZBTB32_uc002oaz.2_RNA	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	125					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCAGGCCTGAAGAAACATCAG	0.577													0	0	0	0.007413	0	20	88										C	36205902	A	C	36205902	3	2	36	1	0	0	0	0	1	0	0	0	17532	72	3	5	376	5	ZBTB32	19	36205902	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	16202384	36205902	22923081	156	8987										
HNRNPL	3191	broad.mit.edu	37	chr19	39329230	39329230	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	caggcatgatggctggctgcTtggagacactgcagcaagga	15	9	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:39329230T>C	uc010xul.1	-	10	1375	c.1364A>G	c.(1363-1365)AAG>AGG	p.K455R	HNRNPL_uc010ege.1_Intron|HNRNPL_uc002ojj.1_Missense_Mutation_p.K111R|HNRNPL_uc002ojo.1_Missense_Mutation_p.K33R|HNRNPL_uc002ojk.2_Missense_Mutation_p.K111R|HNRNPL_uc002ojl.2_Missense_Mutation_p.K111R|HNRNPL_uc010xum.1_Missense_Mutation_p.K322R	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	455	RRM 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			GGCTGGCTGCTTGGAGACACT	0.542													0	0	0	0.016723	0	11	66										C	39329230	T	C	39329230	3	2	36	1	0	0	0	0	1	0	0	0	7270	1609	56	5	421	5	HNRNPL	19	39329230	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	3123328	39329230	19799753	157	8988										
PLEKHG2	64857	broad.mit.edu	37	chr19	39909602	39909602	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgtggattcactgtctccagCgcctcttctttgagaaccac	8	13	4	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:39909602C>T	uc010xuz.1	+	11	1547	c.1222C>T	c.(1222-1224)CGC>TGC	p.R408C	PLEKHG2_uc010xuy.1_Missense_Mutation_p.R349C|PLEKHG2_uc002olj.2_Missense_Mutation_p.R408C|PLEKHG2_uc010xva.1_Missense_Mutation_p.R215C	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	408	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTGTCTCCAGCGCCTCTTCTT	0.612													0	0	0	0.01441	0	86	180										T	39909602	C	T	39909602	3	4	36	1	0	0	0	0	1	0	0	0	12069	768	27	2	1260	2	PLEKHG2	19	39909602	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	580372	39909602	19219381	158	8989										
C19orf54	284325	broad.mit.edu	37	chr19	41248527	41248527	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgccaactcttgccctgcttGgacagcaggtagacagctcc	10	14	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:41248527G>A	uc002oou.1	-	6	987	c.867C>T	c.(865-867)TCC>TCT	p.S289S	C19orf54_uc002oow.1_Silent_p.S117S|C19orf54_uc002oox.1_RNA|C19orf54_uc002ooy.1_Intron|C19orf54_uc010xvs.1_RNA	NM_198476	NP_940878	Q5BKX5	CS054_HUMAN	hypothetical protein LOC284325	289											0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TGCCCTGCTTGGACAGCAGGT	0.657													0	0	0	0.008291	0	10	34										A	41248527	G	A	41248527	2	1	36	1	0	0	0	0	0	0	0	1	1936	1335	47	2		2	C19orf54	19	41248527	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	1338925	41248527	17880456	159	8990										
CEACAM6	4680	broad.mit.edu	37	chr19	42260767	42260767	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	taccccaatgcatccctgctGatccagaacgtcacccagaa	6	16	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:42260767G>A	uc002orm.2	+	2	473	c.324G>A	c.(322-324)CTG>CTA	p.L108L		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	108	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CATCCCTGCTGATCCAGAACG	0.458													0	0	0	0.01441	0	166	382										A	42260767	G	A	42260767	2	1	36	1	0	0	0	0	0	0	0	1	3196	1277	45	1		1	CEACAM6	19	42260767	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	1012240	42260767	16868216	160	8991										
ERCC2	2068	broad.mit.edu	37	chr19	45856352	45856352	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tccactcaccaaagtcgattCcctcggacactttgccccgg	7	17	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:45856352C>G	uc002pbj.2	-	19	1867	c.1820G>C	c.(1819-1821)GGA>GCA	p.G607A	ERCC2_uc002pbh.2_Missense_Mutation_p.G170A|ERCC2_uc002pbi.2_Missense_Mutation_p.G300A|ERCC2_uc010ejz.2_Missense_Mutation_p.G529A|ERCC2_uc002pbk.2_Missense_Mutation_p.G583A	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	607	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		AAAGTCGATTCCCTCGGACAC	0.642			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.01441	0	43	109										G	45856352	C	G	45856352	3	3	36	1	0	0	0	0	1	0	0	0	5213	855	30	1	482	1	ERCC2	19	45856352	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	3595585	45856352	13272631	161	8992										
GIPR	2696	broad.mit.edu	37	chr19	46172841	46172841	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ctgtgcgggctgctgctccaGagggcggaggtgaggaagcg	20	9	0	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:46172841G>A	uc002pcu.1	+	2	162	c.63G>A	c.(61-63)CAG>CAA	p.Q21Q	GIPR_uc002pct.1_Silent_p.Q21Q|GIPR_uc010xxp.1_Silent_p.Q21Q|GIPR_uc010xxq.1_RNA	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	21					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		TGCTGCTCCAGAGGGCGGAGG	0.597													0	0	0	0.00308	0	6	12										A	46172841	G	A	46172841	2	1	36	1	0	0	0	0	0	0	0	1	6395	933	33	1		1	GIPR	19	46172841	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	316489	46172841	12956142	162	8993										
SLC6A16	28968	broad.mit.edu	37	chr19	49797169	49797169	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgcataatccctattgcgctGctcagccccatggccagcaa	8	15	1	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:49797169G>A	uc002pmz.2	-	9	1767	c.1533C>T	c.(1531-1533)AGC>AGT	p.S511S	SLC6A16_uc002pna.2_Silent_p.S511S	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	511	Helical; Name=8; (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		CTATTGCGCTGCTCAGCCCCA	0.483													0	0	0	0.01441	0	86	176										A	49797169	G	A	49797169	2	1	36	1	0	0	0	0	0	0	0	1	14679	1310	46	2		2	SLC6A16	19	49797169	Silent	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	3624328	49797169	9331814	163	8994										
VRK3	51231	broad.mit.edu	37	chr19	50492998	50492998	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tttgccacttgggcaatagcGgaaggcgaagccatagcctg	13	10	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:50492998G>A	uc002prg.2	-	11	1092	c.994C>T	c.(994-996)CGC>TGC	p.R332C	VRK3_uc002prh.1_Missense_Mutation_p.R332C|VRK3_uc002pri.1_Missense_Mutation_p.R282C|VRK3_uc010ens.2_Missense_Mutation_p.R332C|VRK3_uc010ybl.1_Missense_Mutation_p.R282C|VRK3_uc010ybm.1_Missense_Mutation_p.R101C|VRK3_uc002prj.1_Missense_Mutation_p.R282C|VRK3_uc002prk.1_Missense_Mutation_p.R332C|VRK3_uc010ent.1_Missense_Mutation_p.R88C|VRK3_uc002prl.2_Missense_Mutation_p.R332C|VRK3_uc010ybn.1_3'UTR	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	332	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGGCAATAGCGGAAGGCGAAG	0.552													0	0	0	0.012319	0	20	28										A	50492998	G	A	50492998	3	1	36	1	0	0	0	0	1	0	0	0	17218	1116	39	2	446	2	VRK3	19	50492998	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08	695829	50492998	8635985	164	8995										
ZNF813	126017	broad.mit.edu	37	chr19	53994029	53994029	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tcaacatcccaaagaatttcTtgtaggcccaaaacccatat	4	12	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr19:53994029T>G	uc002qbu.2	+	4	671	c.543T>G	c.(541-543)TCT>TCG	p.S181S	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AAAGAATTTCTTGTAGGCCCA	0.388													0	0	0	0.011902	0	44	248										G	53994029	T	G	53994029	2	3	36	1	0	0	0	0	0	0	0	1	18172	1596	56	5		5	ZNF813	19	53994029	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	3501031	53994029	5134954	165	8996										
ZNF133	7692	broad.mit.edu	37	chr20	18295856	18295856	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aaggtaacatccagcctgggGatccgggcccaggggaccag	15	12	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr20:18295856G>T	uc010gcq.2	+	5	666	c.361G>T	c.(361-363)GAT>TAT	p.D121Y	ZNF133_uc010zrv.1_Missense_Mutation_p.D124Y|ZNF133_uc010zrw.1_Missense_Mutation_p.D58Y|ZNF133_uc010gcr.2_Missense_Mutation_p.D121Y|ZNF133_uc010zrx.1_Missense_Mutation_p.D26Y|ZNF133_uc002wql.3_Missense_Mutation_p.D120Y|ZNF133_uc010gcs.2_Missense_Mutation_p.D120Y|ZNF133_uc010zry.1_Missense_Mutation_p.D26Y|ZNF133_uc002wqm.2_Missense_Mutation_p.D121Y	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	121						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						CCAGCCTGGGGATCCGGGCCC	0.562													1	0	3.47267e-51	0.01441	3.83254e-51	79	185										T	18295856	G	T	18295856	3	4	36	1	0	0	0	0	1	0	0	0	17720	1174	41	3	368	3	ZNF133	20	18295856	Missense_Mutation	SNP	G	TCGA-CU-A0YR-01A-12D-A10S-08		18295856	44729664	166	8997										
POFUT1	23509	broad.mit.edu	37	chr20	30803206	30803206	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aagcgggtggcatactgcttTgaggtggcagcccagcgaag	16	9	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr20:30803206T>C	uc002wxp.2	+	3	430	c.381T>C	c.(379-381)TTT>TTC	p.F127F	POFUT1_uc002wxo.2_Silent_p.F127F|POFUT1_uc010ztt.1_Silent_p.F19F|POFUT1_uc010ztu.1_Intron	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	127					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CATACTGCTTTGAGGTGGCAG	0.602													0	0	0	0.01441	0	85	180										C	30803206	T	C	30803206	2	2	36	1	0	0	0	0	0	0	0	1	12183	1809	63	5		5	POFUT1	20	30803206	Silent	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	12507350	30803206	32222314	167	8998										
CDK5RAP1	51654	broad.mit.edu	37	chr20	31962020	31962020	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	catgaatcagctgcagaaccTgatgaaacagaacacattat	7	9	1	5			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr20:31962020T>G	uc010gek.2	-	10	1274	c.1150_splice	c.e10-1	p.V384_splice	CDK5RAP1_uc002wyy.2_Splice_Site_p.V280_splice|CDK5RAP1_uc002wyz.2_Splice_Site_p.V370_splice|CDK5RAP1_uc002wza.2_Splice_Site_p.V370_splice|CDK5RAP1_uc010gel.2_Splice_Site_p.V279_splice|CDK5RAP1_uc010gem.2_Splice_Site_p.V293_splice|CDK5RAP1_uc002wzc.1_Splice_Site_p.V370_splice|CDK5RAP1_uc002wzb.1_5'Flank	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1						brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						CTGCAGAACCTGATGAAACAG	0.463													0	0	0	0.021523	0	27	155										G	31962020	T	G	31962020	5	3	36	1	0	0	0	0	0	0	1	0	3145	1594	55	5	681	5	CDK5RAP1	20	31962020	Splice_Site	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	1158814	31962020	31063500	168	8999										
TRPC4AP	26133	broad.mit.edu	37	chr20	33680620	33680620	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aaacaggaagcaagcggcctCggggccgcggagatttctac	14	11	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr20:33680620C>T	uc002xbk.2	-	1	1	c.-33_splice	c.e1-1		TRPC4AP_uc002xbl.2_Splice_Site|TRPC4AP_uc010zur.1_Splice_Site|TRPC4AP_uc002xbm.1_Splice_Site	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a						protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			CAAGCGGCCTCGGGGCCGCGG	0.746													0	0	0	0.014758	0	3	10										T	33680620	C	T	33680620	5	4	36	1	0	0	0	0	0	0	1	0	16578	899	31	1		1	TRPC4AP	20	33680620	Splice_Site	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	1718600	33680620	29344900	169	9000										
CPNE1	8904	broad.mit.edu	37	chr20	34214192	34214192	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gggggcctgtgcaggatcctTggctgagggtggaagtggct	20	7	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr20:34214192T>C	uc002xdf.2	-	18	1948	c.1585A>G	c.(1585-1587)AAG>GAG	p.K529E	CPNE1_uc002xdc.2_Missense_Mutation_p.K191E|CPNE1_uc010zvj.1_Missense_Mutation_p.K534E|CPNE1_uc002xde.2_Missense_Mutation_p.K505E|CPNE1_uc002xdg.2_Missense_Mutation_p.K473E|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.K529E|CPNE1_uc002xdi.2_Missense_Mutation_p.K529E|CPNE1_uc002xdj.2_Missense_Mutation_p.K529E|CPNE1_uc002xdk.2_Missense_Mutation_p.K529E|CPNE1_uc002xdl.2_Missense_Mutation_p.K529E|CPNE1_uc002xdm.2_Missense_Mutation_p.K529E	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	529					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GCAGGATCCTTGGCTGAGGGT	0.627													0	0	0	0.01441	0	88	207										C	34214192	T	C	34214192	3	2	36	1	0	0	0	0	1	0	0	0	3811	1821	63	5	32	5	CPNE1	20	34214192	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	533572	34214192	28811328	170	9001										
ICOSLG	23308	broad.mit.edu	37	chr21	45651249	45651249	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gcaggcacaggacagccaggAtgctccacgtggccgcgttt	14	13	0	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr21:45651249A>C	uc002zee.2	-	5	910	c.776T>G	c.(775-777)ATC>AGC	p.I259S	ICOSLG_uc011afc.1_Missense_Mutation_p.I169S|ICOSLG_uc002zef.2_Missense_Mutation_p.I142S|ICOSLG_uc010gpp.1_Missense_Mutation_p.I259S	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	259	Helical; (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		GACAGCCAGGATGCTCCACGT	0.562													0	0	0	0.009535	0	25	45										C	45651249	A	C	45651249	3	2	36	1	0	0	0	0	1	0	0	0	7487	333	12	5	144	5	ICOSLG	21	45651249	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08		45651249	2478646	171	9002										
EP300	2033	broad.mit.edu	37	chr22	41489057	41489057	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cgccttcagccaagcggcctAaactctcatctccggccctc	7	19	3	0			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr22:41489057A>G	uc003azl.3	+	1	444	c.49A>G	c.(49-51)AAA>GAA	p.K17E		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	17	Interaction with ALX1.|Nuclear localization signal (Potential).				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CAAGCGGCCTAAACTCTCATC	0.552			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.01441	0	75	132										G	41489057	A	G	41489057	3	3	36	1	0	0	0	0	1	0	0	0	5148	363	13	5	51	5	EP300	22	41489057	Missense_Mutation	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08		41489057	9815509	172	9003										
ACO2	50	broad.mit.edu	37	chr22	41865168	41865168	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	aaaatggcgccctacagcctActggtgactcggctgcaggt	12	12	0	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr22:41865168A>G	uc003bac.2	+	1	40	c.18A>G	c.(16-18)CTA>CTG	p.L6L	PHF5A_uc003bab.2_5'Flank|ACO2_uc003bad.2_Silent_p.L6L	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	6					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CCTACAGCCTACTGGTGACTC	0.647													0	0	0	0.01892	0	22	108										G	41865168	A	G	41865168	2	3	36	1	0	0	0	0	0	0	0	1	147	378	14	5		5	ACO2	22	41865168	Silent	SNP	A	TCGA-CU-A0YR-01A-12D-A10S-08	376111	41865168	9439398	173	9004										
GTSE1	51512	broad.mit.edu	37	chr22	46704392	46704392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	cgtggaggtgtacaaagaagCtcacttactggctttacaca	10	9	1	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr22:46704392C>T	uc011aqy.1	+	4	526	c.314C>T	c.(313-315)GCT>GTT	p.A105V	GTSE1_uc011aqz.1_5'UTR	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	86					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		TACAAAGAAGCTCACTTACTG	0.567													0	0	0	0.005443	0	28	133										T	46704392	C	T	46704392	3	4	36	1	0	0	0	0	1	0	0	0	6885	797	28	2	324	2	GTSE1	22	46704392	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08	4839224	46704392	4600174	174	9005										
CPT1B	1375	broad.mit.edu	37	chr22	51007850	51007850	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	gtttccaaagcgctgggcgtTctgtgggagccaagagttca	14	9	2	1			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chr22:51007850T>A	uc003bmk.3	-	18	2398	c.2236A>T	c.(2236-2238)AAC>TAC	p.N746Y	CPT1B_uc003bml.2_Missense_Mutation_p.N746Y|CPT1B_uc003bmm.2_Missense_Mutation_p.N746Y|CPT1B_uc003bmo.2_Missense_Mutation_p.N746Y|CPT1B_uc011asa.1_Missense_Mutation_p.N712Y|CPT1B_uc003bmn.2_Missense_Mutation_p.N746Y|CPT1B_uc011asb.1_Missense_Mutation_p.N665Y|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.N541Y|uc003bmr.1_5'Flank	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	746	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		CGCTGGGCGTTCTGTGGGAGC	0.537													0	0	0	0.008871	0	21	98										A	51007850	T	A	51007850	3	1	36	1	0	0	0	0	1	0	0	0	3832	1797	62	5	86	5	CPT1B	22	51007850	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	4303458	51007850	296716	175	9006										
BMX	660	broad.mit.edu	37	chrX	15574250	15574250	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tgtcttccattgaaccacttCgggaaaaagacaagcattga	8	9	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chrX:15574250C>T	uc004cww.2	+	19	2196	c.2008C>T	c.(2008-2010)CGG>TGG	p.R670W	BMX_uc004cwx.3_Missense_Mutation_p.R670W|BMX_uc004cwy.3_Missense_Mutation_p.R670W	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	670	Protein kinase.		R -> W (in a lung large cell carcinoma sample; somatic mutation).		cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity	p.R670W(2)		lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					TGAACCACTTCGGGAAAAAGA	0.383													0	0	0	0.01441	0	56	127										T	15574250	C	T	15574250	3	4	36	1	0	0	0	0	1	0	0	0	1473	875	31	1	2078	1	BMX	23	15574250	Missense_Mutation	SNP	C	TCGA-CU-A0YR-01A-12D-A10S-08		15574250	139696310	176	9007										
ACE2	59272	broad.mit.edu	37	chrX	15599440	15599440	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	tggaattttcccagaatcctTgagtcatattaggaagacca	8	8	1	3			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chrX:15599440T>G	uc004cxa.1	-	8	1142	c.974A>C	c.(973-975)CAA>CCA	p.Q325P	ACE2_uc004cxb.2_Missense_Mutation_p.Q325P	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	325	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	CCAGAATCCTTGAGTCATATT	0.478													0	0	0	0.01441	0	115	81										G	15599440	T	G	15599440	3	3	36	1	0	0	0	0	1	0	0	0	137	1812	63	5	1487	5	ACE2	23	15599440	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	25190	15599440	139671120	177	9008										
NKRF	55922	broad.mit.edu	37	chrX	118723319	118723319	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0734463276836158	13	0.261838316707236	1.23473190157872	1.66741573033708	1.1070547062074	0.128346121057119	0.256692242114238	0	ataaattagtaagatctcaaTttgcttgaggcataacaagc	7	6	1	2			TCGA-CU-A0YR-01A-12D-A10S-08	TCGA-CU-A0YR-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	31382822-3792-47bc-99e8-8a1ee1e4e58b	27561a6d-8637-4937-ade5-e4e02bf79fec	g.chrX:118723319T>C	uc004erq.2	-	2	2722	c.2069A>G	c.(2068-2070)AAT>AGT	p.N690S	NKRF_uc004err.2_Missense_Mutation_p.N690S	NM_017544	NP_060014	O15226	NKRF_HUMAN	transcription factor NRF	690					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			ovary(1)|central_nervous_system(1)	2						AAGATCTCAATTTGCTTGAGG	0.383													0	0	0	0.01441	0	48	25										C	118723319	T	C	118723319	3	2	36	1	0	0	0	0	1	0	0	0	10447	1493	52	5	7	5	NKRF	23	118723319	Missense_Mutation	SNP	T	TCGA-CU-A0YR-01A-12D-A10S-08	103123879	118723319	36547241	178	9009										
PLEKHN1	84069	broad.mit.edu	37	chr1	909268	909268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gccctcgagcccactcccctCggtgcctgtgtctgtgcctg	11	18	1	0	rs140958781	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:909268C>T	uc001ace.2	+	13	1681	c.1646C>T	c.(1645-1647)TCG>TTG	p.S549L	PLEKHN1_uc001acd.2_Missense_Mutation_p.S497L|PLEKHN1_uc001acf.2_Missense_Mutation_p.S462L	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	549											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCACTCCCCTCGGTGCCTGTG	0.697													0	0	0	0.104719	0	28	75										T	909268	C	T	909268	3	4	37	1	0	0	0	0	1	0	0	0	12083	893	31	1	1580	1	PLEKHN1	1	909268	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		909268	248341353	1	9010										
TP73	7161	broad.mit.edu	37	chr1	3644231	3644231	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cggtcctttgagggccgcatCtgcgcctgtcctggccgcga	14	15	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:3644231C>T	uc001akp.2	+	8	992	c.882C>T	c.(880-882)ATC>ATT	p.I294I	TP73_uc001akq.2_Silent_p.I294I|TP73_uc010nzj.1_Silent_p.I245I|TP73_uc001akr.2_Silent_p.I245I|TP73_uc009vlk.1_Silent_p.I245I|TP73_uc001aks.2_Silent_p.I245I|TP73_uc010nzk.1_Silent_p.I223I|TP73_uc010nzl.1_5'UTR	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	294	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		AGGGCCGCATCTGCGCCTGTC	0.672													0	0	0	0.02938	0	7	14										T	3644231	C	T	3644231	2	4	37	1	0	0	0	0	0	0	0	1	16390	903	32	1		1	TP73	1	3644231	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2734963	3644231	245606390	2	9011										
TNFRSF8	943	broad.mit.edu	37	chr1	12202457	12202457	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccgagttggaggaggagctgGaggcggaccataccccccac	15	13	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:12202457G>C	uc001atq.2	+	15	1879	c.1657G>C	c.(1657-1659)GAG>CAG	p.E553Q	TNFRSF8_uc010obc.1_Missense_Mutation_p.E441Q|TNFRSF8_uc001atr.2_Missense_Mutation_p.E90Q|TNFRSF8_uc001ats.2_Missense_Mutation_p.E34Q	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	553	Cytoplasmic (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGGAGCTGGAGGCGGACCA	0.652													0	0	0	0.105934	0	13	31										C	12202457	G	C	12202457	3	2	37	1	0	0	0	0	1	0	0	0	16296	1175	41	1	1715	1	TNFRSF8	1	12202457	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	8558226	12202457	237048164	3	9012										
SPEN	23013	broad.mit.edu	37	chr1	16199610	16199610	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acttcatgcacgagaaggacGttatgagcggagacttgatg	13	7	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:16199610G>A	uc001axk.1	+	2	587	c.383G>A	c.(382-384)CGT>CAT	p.R128H	SPEN_uc010obp.1_5'Flank	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	128	Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGAGAAGGACGTTATGAGCGG	0.488													0	0	0	0.076483	0	19	38										A	16199610	G	A	16199610	3	1	37	1	0	0	0	0	1	0	0	0	15037	1145	40	2	389	2	SPEN	1	16199610	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	3997153	16199610	233051011	4	9013										
C1orf201	90529	broad.mit.edu	37	chr1	24706145	24706145	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cataggcagagttcttacatTgtaatagtttggtgcaggag	12	5	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:24706145T>A	uc001bjc.2	-	5	595	c.460A>T	c.(460-462)AAT>TAT	p.N154Y	C1orf201_uc001bja.2_Missense_Mutation_p.N107Y|C1orf201_uc001bjb.2_Missense_Mutation_p.N62Y|C1orf201_uc001bjd.2_Missense_Mutation_p.N154Y|C1orf201_uc001bje.1_Missense_Mutation_p.N107Y|C1orf201_uc001bjf.2_Missense_Mutation_p.N22Y			Q5TH74	CA201_HUMAN	RecName: Full=UPF0490 protein C1orf201;	154										ovary(1)|breast(1)	2		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0191)|all_lung(284;0.0251)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.056)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.48e-25)|Colorectal(126;7.29e-08)|COAD - Colon adenocarcinoma(152;3.85e-06)|GBM - Glioblastoma multiforme(114;0.000399)|BRCA - Breast invasive adenocarcinoma(304;0.00107)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00393)|READ - Rectum adenocarcinoma(331;0.0672)|Lung(427;0.145)		GTTCTTACATTGTAATAGTTT	0.373													0	0	0	0.09319	0	11	53										A	24706145	T	A	24706145	3	1	37	1	0	0	0	0	1	0	0	0	2027	1812	63	5	564	5	C1orf201	1	24706145	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	8506535	24706145	224544476	5	9014										
ARID1A	8289	broad.mit.edu	37	chr1	27059204	27059204	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atttgggtctcaggcatcctCagccccctcaatgacctcca	7	16	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:27059204C>T	uc001bmv.1	+	4	2214	c.1841C>T	c.(1840-1842)TCA>TTA	p.S614L	ARID1A_uc001bmt.1_Missense_Mutation_p.S614L|ARID1A_uc001bmu.1_Missense_Mutation_p.S614L|ARID1A_uc001bmw.1_Missense_Mutation_p.S231L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	614					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGGCATCCTCAGCCCCCTCA	0.478			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.062417	0	17	30										T	27059204	C	T	27059204	3	4	37	1	0	0	0	0	1	0	0	0	913	838	29	1	1855	1	ARID1A	1	27059204	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2353059	27059204	222191417	6	9015										
PUM1	9698	broad.mit.edu	37	chr1	31478699	31478699	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aagttcctcaagccaacttaCaaatcctccttttcttagac	3	13	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:31478699C>T	uc001bsi.1	-	5	833	c.720_splice	c.e5+1	p.F240_splice	PUM1_uc001bsg.1_Intron|PUM1_uc001bsh.1_Splice_Site_p.F240_splice|PUM1_uc001bsj.1_Splice_Site_p.F240_splice|PUM1_uc010oga.1_Intron|PUM1_uc001bsk.1_Splice_Site_p.F276_splice|PUM1_uc010ogb.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2						cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AGCCAACTTACAAATCCTCCT	0.398													0	0	0	0.09836	0	33	24										T	31478699	C	T	31478699	5	4	37	1	0	0	0	0	0	0	1	0	12825	492	17	2	2917	2	PUM1	1	31478699	Splice_Site	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4419495	31478699	217771922	7	9016										
RNF220	55182	broad.mit.edu	37	chr1	44878109	44878109	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccccaatcagtatgctgaatCatagtggtgtgggggctttc	12	9	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:44878109C>G	uc001clv.1	+	2	700	c.340C>G	c.(340-342)CAT>GAT	p.H114D	RNF220_uc001clw.1_Missense_Mutation_p.H114D	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	114					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TATGCTGAATCATAGTGGTGT	0.537													0	0	0	0.139131	0	108	78										G	44878109	C	G	44878109	3	3	37	1	0	0	0	0	1	0	0	0	13483	826	29	1	342	1	RNF220	1	44878109	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	13399410	44878109	204372512	8	9017										
STIL	6491	broad.mit.edu	37	chr1	47767334	47767334	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatcaaaaagtccccaggaaGagaagcagtaggggttattt	11	6	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:47767334G>A	uc001crc.1	-	5	507	c.352C>T	c.(352-354)CTT>TTT	p.L118F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.L118F|STIL_uc010omo.1_Missense_Mutation_p.L118F|STIL_uc001crd.1_Missense_Mutation_p.L118F|STIL_uc001cre.1_Missense_Mutation_p.L118F|STIL_uc001crg.1_Missense_Mutation_p.L118F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	118					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TCCCCAGGAAGAGAAGCAGTA	0.388													0	0	0	0.11911	0	12	14										A	47767334	G	A	47767334	3	1	37	1	0	0	0	0	1	0	0	0	15281	942	33	1	3566	1	STIL	1	47767334	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2889225	47767334	201483287	9	9018										
INADL	10207	broad.mit.edu	37	chr1	62330234	62330234	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ataatgaaccatccgagtctCaagaggcaagaaccgggagg	12	9	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:62330234C>G	uc001dab.2	+	20	2878	c.2764C>G	c.(2764-2766)CAA>GAA	p.Q922E	INADL_uc009waf.1_Missense_Mutation_p.Q922E|INADL_uc001daa.2_Missense_Mutation_p.Q922E|INADL_uc001dad.3_Missense_Mutation_p.Q619E|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	922					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ATCCGAGTCTCAAGAGGCAAG	0.483													0	0	0	0.139131	0	58	54										G	62330234	C	G	62330234	3	3	37	1	0	0	0	0	1	0	0	0	7731	827	29	1	2838	1	INADL	1	62330234	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	14562900	62330234	186920387	10	9019										
MSH4	4438	broad.mit.edu	37	chr1	76280741	76280741	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	actatccaaaggaaatacttCaatgaaacaaaaggattaga	6	6	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:76280741C>A	uc001dhd.1	+	5	776	c.735C>A	c.(733-735)TTC>TTA	p.F245L		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	245					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GGAAATACTTCAATGAAACAA	0.323								MMR					1	0	4.68919e-08	0.069234	4.82149e-08	8	34										A	76280741	C	A	76280741	3	1	37	1	0	0	0	0	1	0	0	0	9872	825	29	3	753	3	MSH4	1	76280741	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	13950507	76280741	172969880	11	9020										
ZZZ3	26009	broad.mit.edu	37	chr1	78031766	78031766	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acaatgaagaaaacacttacCagtctgaacaagaatcacag	6	9	2	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:78031766C>G	uc001dhq.2	-	14	3043	c.2567G>C	c.(2566-2568)TGT>TCT	p.C856S	ZZZ3_uc001dhr.2_Missense_Mutation_p.C362S|ZZZ3_uc001dhp.2_Missense_Mutation_p.C855S	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	856	ZZ-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						AAACACTTACCAGTCTGAACA	0.393													0	0	0	0.184627	0	4	15										G	78031766	C	G	78031766	3	3	37	1	0	0	0	0	1	0	0	0	18253	608	21	4	152	4	ZZZ3	1	78031766	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1751025	78031766	171218855	12	9021										
FUBP1	8880	broad.mit.edu	37	chr1	78428504	78428504	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	catagtctatctgttgtggaGtgccacgaattgtaaataac	9	7	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:78428504G>A	uc001dii.2	-	14	1384	c.1295C>T	c.(1294-1296)ACT>ATT	p.T432I	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.T453I	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	432	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CTGTTGTGGAGTGCCACGAAT	0.368													0	0	0	0.115264	0	3	30										A	78428504	G	A	78428504	3	1	37	1	0	0	0	0	1	0	0	0	6092	1029	36	2	667	2	FUBP1	1	78428504	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	396738	78428504	170822117	13	9022										
IFI44L	10964	broad.mit.edu	37	chr1	79107468	79107468	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tttcattttcaggtgcaattGagagagcgttacagccctgc	10	9	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:79107468G>A	uc010oro.1	+	9	1512	c.1333G>A	c.(1333-1335)GAG>AAG	p.E445K	IFI44L_uc010orp.1_Missense_Mutation_p.E182K|IFI44L_uc010orq.1_Missense_Mutation_p.E182K	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	445						cytoplasm					0						AGGTGCAATTGAGAGAGCGTT	0.448													0	0	0	0.139131	0	44	121										A	79107468	G	A	79107468	3	1	37	1	0	0	0	0	1	0	0	0	7518	1291	45	1	1363	1	IFI44L	1	79107468	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	678964	79107468	170143153	14	9023										
GBP1	2633	broad.mit.edu	37	chr1	89522638	89522638	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cctgtgcaggtccagcagctCctggagggtttctgtgggca	15	11	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:89522638C>G	uc001dmx.2	-	7	1274	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	352					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCCAGCAGCTCCTGGAGGGTT	0.517													0	0	0	0.069288	0	18	48										G	89522638	C	G	89522638	3	3	37	1	0	0	0	0	1	0	0	0	6273	864	30	1	744	1	GBP1	1	89522638	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10415170	89522638	159727983	15	9024										
AMY2B	280	broad.mit.edu	37	chr1	104116527	104116527	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatctaaacagtaactggttCcctgcaggaagtaaaccttt	7	9	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:104116527C>T	uc001duq.2	+	6	1327	c.711C>T	c.(709-711)TTC>TTT	p.F237F	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Silent_p.F237F|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	237					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GTAACTGGTTCCCTGCAGGAA	0.363													0	0	0	0.139131	0	32	35										T	104116527	C	T	104116527	2	4	37	1	0	0	0	0	0	0	0	1	595	854	30	1		1	AMY2B	1	104116527	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	14593889	104116527	145134094	16	9025										
NBPF16	728936	broad.mit.edu	37	chr1	148754879	148754879	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agtagagcctgaagtcttgcAggactcactggatagatatt	11	7	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:148754879A>T	uc010pba.1	+	14	1726	c.1535A>T	c.(1534-1536)CAG>CTG	p.Q512L	NBPF16_uc009wkt.1_Missense_Mutation_p.Q292L	NM_001102663	NP_001096133			hypothetical protein LOC728936												0	all_hematologic(923;0.032)					GAAGTCTTGCAGGACTCACTG	0.468													0	0	0	0.115264	0	3	47										T	148754879	A	T	148754879	3	4	37	1	0	0	0	0	1	0	0	0	10196	188	7	5	3658	5	NBPF16	1	148754879	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	44638352	148754879	100495742	17	9026										
SNX27	81609	broad.mit.edu	37	chr1	151584734	151584735	+	In_Frame_Ins	INS	-	-	GGC													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cccctcacaggaacggaggtINSggcggcggcggcggggggtc							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:151584734_151584735insGGC	uc001eyn.1	+	1	73_74	c.57_58insGGC	c.(55-60)insGGC	p.25_26insG		NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	25_26					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAcggaggtggcggcggcgg	0.441																		10	20	---	---								GGC	151584735	-	GGC	151584734	7	5	37	1	0	1	1	0	0	0	0	0	14897	1683	59	0	59	0	SNX27	1	151584734	In_Frame_Ins	INS	-	TCGA-CU-A3KJ-01A-11D-A21A-08	2829855	151584734	97665887	18	9027										
SSR2	6746	broad.mit.edu	37	chr1	155989830	155989830	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccaacattgtagatgttgtaCtgcaaggtcaggtctcgtcc	10	10	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:155989830C>T	uc001fmx.2	-	2	209	c.129G>A	c.(127-129)CAG>CAA	p.Q43Q	SSR2_uc001fmw.2_RNA|SSR2_uc001fmy.2_RNA|SSR2_uc010pgv.1_Silent_p.Q62Q|SSR2_uc010pgw.1_Silent_p.Q62Q	NM_003145	NP_003136	P43308	SSRB_HUMAN	signal sequence receptor, beta precursor	43	Lumenal (Potential).				cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGATGTTGTACTGCAAGGTCA	0.473													0	0	0	0.069234	0	8	65										T	155989830	C	T	155989830	2	4	37	1	0	0	0	0	0	0	0	1	15190	564	20	2		2	SSR2	1	155989830	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4405096	155989830	93260791	19	9028										
KIRREL	55243	broad.mit.edu	37	chr1	158059548	158059548	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaggcagtgcagtatgctgtGaggggtgacggtggcaaggt	20	5	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:158059548G>C	uc001frn.3	+	10	1616	c.1212G>C	c.(1210-1212)GTG>GTC	p.V404V	KIRREL_uc010pib.1_Silent_p.V304V|KIRREL_uc009wsq.2_Silent_p.V240V|KIRREL_uc001fro.3_Silent_p.V218V	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	404	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					AGTATGCTGTGAGGGGTGACG	0.602													0	0	0	0.139131	0	38	211										C	158059548	G	C	158059548	2	2	37	1	0	0	0	0	0	0	0	1	8324	1277	45	1		1	KIRREL	1	158059548	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2069718	158059548	91191073	20	9029										
DDR2	4921	broad.mit.edu	37	chr1	162750019	162750019	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aaatccaccttctgctccttCaacaaggcgacgagtgatgc	8	13	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:162750019C>A	uc001gcf.2	+	19	3016	c.2551C>A	c.(2551-2553)CAA>AAA	p.Q851K	DDR2_uc001gcg.2_Missense_Mutation_p.Q851K|uc001gch.1_5'Flank	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	851	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCTGCTCCTTCAACAAGGCGA	0.527													1	0	2.68362e-12	0.09319	2.83031e-12	12	93										A	162750019	C	A	162750019	3	1	37	1	0	0	0	0	1	0	0	0	4337	827	29	3	2613	3	DDR2	1	162750019	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4690471	162750019	86500602	21	9030										
ADCY10	55811	broad.mit.edu	37	chr1	167792259	167792259	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cacttaccagaataaagcagGatgtccaagcagacaaaata	7	9	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:167792259G>T	uc001ger.2	-	29	4453	c.4155C>A	c.(4153-4155)ATC>ATA	p.I1385I	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Silent_p.I1293I|ADCY10_uc010plj.1_Silent_p.I1232I	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1385					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AATAAAGCAGGATGTCCAAGC	0.502													1	0	1.33834e-09	0.189662	1.38916e-09	16	39										T	167792259	G	T	167792259	2	4	37	1	0	0	0	0	0	0	0	1	293	1164	41	3		3	ADCY10	1	167792259	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	5042240	167792259	81458362	22	9031										
GPR161	23432	broad.mit.edu	37	chr1	168066120	168066120	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aagaggaggtggaggtgctgGagttcttcctcccggtcctc	15	10	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:168066120G>C	uc001gfc.2	-	5	1039	c.725C>G	c.(724-726)TCC>TGC	p.S242C	GPR161_uc001gfb.2_Missense_Mutation_p.S110C|GPR161_uc010pll.1_Missense_Mutation_p.S152C|GPR161_uc010plm.1_Missense_Mutation_p.S128C|GPR161_uc009wvo.2_Missense_Mutation_p.S259C|GPR161_uc001gfd.2_Missense_Mutation_p.S242C|GPR161_uc010pln.1_Missense_Mutation_p.S262C|GPR161_uc001gfe.1_Missense_Mutation_p.S242C	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	242	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					GGAGGTGCTGGAGTTCTTCCT	0.602													0	0	0	0.139131	0	89	106										C	168066120	G	C	168066120	3	2	37	1	0	0	0	0	1	0	0	0	6665	1174	41	1	880	1	GPR161	1	168066120	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	273861	168066120	81184501	23	9032										
RFWD2	64326	broad.mit.edu	37	chr1	176050418	176050418	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caactggcttgcagttcgacTgtcatctatatgaaaaaaaa	7	8	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:176050418T>C	uc001gku.1	-	11	1403	c.1147A>G	c.(1147-1149)AGT>GGT	p.S383G	RFWD2_uc001gkv.1_Missense_Mutation_p.S359G|RFWD2_uc001gkw.1_Missense_Mutation_p.S143G|RFWD2_uc009wwv.2_Missense_Mutation_p.S182G|RFWD2_uc001gkt.1_Missense_Mutation_p.S222G	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	383					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCAGTTCGACTGTCATCTATA	0.323													0	0	0	0.069234	0	9	24										C	176050418	T	C	176050418	3	2	37	1	0	0	0	0	1	0	0	0	13260	1580	55	5	1088	5	RFWD2	1	176050418	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	7984298	176050418	73200203	24	9033										
KIAA1614	57710	broad.mit.edu	37	chr1	180904553	180904553	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctacatcaacggggctccccGgctccgggacgcggggcagg	16	15	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:180904553G>A	uc001gok.2	+	5	1575	c.1508G>A	c.(1507-1509)CGG>CAG	p.R503Q	KIAA1614_uc001gol.1_Missense_Mutation_p.R124Q|KIAA1614_uc001gom.1_Intron	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	503										ovary(3)|skin(1)	4						GGGGCTCCCCGGCTCCGGGAC	0.741													0	0	0	0.021553	0	4	23										A	180904553	G	A	180904553	3	1	37	1	0	0	0	0	1	0	0	0	8248	1116	39	2	1526	2	KIAA1614	1	180904553	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	4854135	180904553	68346068	25	9034										
LAMC2	3918	broad.mit.edu	37	chr1	183208644	183208644	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agcgctgctgctgatgcacaGagggcaaagaatggggccgg	17	9	0	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:183208644G>C	uc001gqa.2	+	20	3329	c.3015G>C	c.(3013-3015)CAG>CAC	p.Q1005H	LAMC2_uc001gpz.3_Missense_Mutation_p.Q1005H|LAMC2_uc010poa.1_Missense_Mutation_p.Q705H	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1005	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						CTGATGCACAGAGGGCAAAGA	0.537													0	0	0	0.183431	0	31	78										C	183208644	G	C	183208644	3	2	37	1	0	0	0	0	1	0	0	0	8615	933	33	1	3093	1	LAMC2	1	183208644	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2304091	183208644	66041977	26	9035										
LAMC2	3918	broad.mit.edu	37	chr1	183209259	183209259	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gactggcctctctgaagagtGagatgagggaagtggaagga	17	5	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:183209259G>C	uc001gqa.2	+	21	3468	c.3154G>C	c.(3154-3156)GAG>CAG	p.E1052Q	LAMC2_uc001gpz.3_Missense_Mutation_p.E1052Q|LAMC2_uc010poa.1_Missense_Mutation_p.E752Q	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1052	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						TCTGAAGAGTGAGATGAGGGA	0.507													0	0	0	0.055883	0	19	74										C	183209259	G	C	183209259	3	2	37	1	0	0	0	0	1	0	0	0	8615	1291	45	1	3236	1	LAMC2	1	183209259	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	615	183209259	66041362	27	9036										
FAM58B	339521	broad.mit.edu	37	chr1	200183191	200183191	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaactgccacagctggcagcGgacccccgttgccgtcactg	12	16	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:200183191G>A	uc009wzi.1	+	1	536	c.500G>A	c.(499-501)CGG>CAG	p.R167Q		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	167					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					AGCTGGCAGCGGACCCCCGTT	0.627													0	0	0	0.173368	0	23	59										A	200183191	G	A	200183191	3	1	37	1	0	0	0	0	1	0	0	0	5591	1116	39	2	502	2	FAM58B	1	200183191	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	16973932	200183191	49067430	28	9037										
NAV1	89796	broad.mit.edu	37	chr1	201749566	201749566	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tagctgggatgaaagcagctCcatcagtagtggactcagcg	13	9	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749566C>A	uc001gwu.2	+	4	1591	c.1244C>A	c.(1243-1245)TCC>TAC	p.S415Y	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Missense_Mutation_p.S24Y|NAV1_uc001gwx.2_Missense_Mutation_p.S24Y|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	415					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						GAAAGCAGCTCCATCAGTAGT	0.463													1	0	4.59853e-10	0.108266	4.78831e-10	25	72										A	201749566	C	A	201749566	3	1	37	1	0	0	0	0	1	0	0	0	10183	855	30	3	1315	3	NAV1	1	201749566	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1566375	201749566	47501055	29	9038			1	31		3	3	112	C		4.744837e-07
NAV1	89796	broad.mit.edu	37	chr1	201749603	201749603	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agcgatgcctcagacaatctCagttcagaagaattcaatgc	8	10	4	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749603C>G	uc001gwu.2	+	4	1628	c.1281C>G	c.(1279-1281)CTC>CTG	p.L427L	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Silent_p.L36L|NAV1_uc001gwx.2_Silent_p.L36L|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	427					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CAGACAATCTCAGTTCAGAAG	0.488													0	0	0	0.092188	0	32	82										G	201749603	C	G	201749603	2	3	37	1	0	0	0	0	0	0	0	1	10183	813	29	1		1	NAV1	1	201749603	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	37	201749603	47501018	30	9039			1	31		3	3	112	C		4.744837e-07
NAV1	89796	broad.mit.edu	37	chr1	201749677	201749677	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cactgcttctcgcaggaactCaacaatagtggtacgtgagt	10	10	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749677C>T	uc001gwu.2	+	4	1702	c.1355C>T	c.(1354-1356)TCA>TTA	p.S452L	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Missense_Mutation_p.S61L|NAV1_uc001gwx.2_Missense_Mutation_p.S61L|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	452					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CGCAGGAACTCAACAATAGTG	0.498													0	0	0	0.144211	0	22	74										T	201749677	C	T	201749677	3	4	37	1	0	0	0	0	1	0	0	0	10183	838	29	1	1426	1	NAV1	1	201749677	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	74	201749677	47500944	31	9040			1	31		3	3	112	C		4.744837e-07
BTG2	7832	broad.mit.edu	37	chr1	203276381	203276382	+	Frame_Shift_Del	DEL	AG	AG	-													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agctgcaccagctgctgcccAgcgagctgaccctgtgggtg							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			AG	-	AG	AG		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:203276381_203276382delAG	uc001gzq.2	+	2	363_364	c.292_293delAG	c.(292-294)AGCfs	p.S98fs	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	98					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			GCTGCTGCCCAGCGAGCTGACC	0.644																		34	93	---	---								-	203276382	AG	-	203276381	7	5	37	1	0	1	0	1	0	0	0	0	1554	188	7	0	298	0	BTG2	1	203276381	Frame_Shift_Del	DEL	AG	TCGA-CU-A3KJ-01A-11D-A21A-08	1526704	203276381	45974240	32	9041										
SLC30A1	7779	broad.mit.edu	37	chr1	211751465	211751465	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggggcgggtgctcttaacgcGaggccccttggggaggccgt	19	11	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:211751465G>A	uc001hio.1	-	1	635	c.490C>T	c.(490-492)CGC>TGC	p.R164C		NM_021194	NP_067017	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter),	164	Cytoplasmic (Potential).				cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		CTCTTAACGCGAGGCCCCTTG	0.701													0	0	0	0.184627	0	4	16										A	211751465	G	A	211751465	3	1	37	1	0	0	0	0	1	0	0	0	14553	1058	37	1	1041	1	SLC30A1	1	211751465	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	8475084	211751465	37499156	33	9042										
KCNK2	3776	broad.mit.edu	37	chr1	215259881	215259881	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcctggtggttgtcctctatCtgatcatcggagccaccgtg	11	12	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:215259881C>G	uc001hkq.2	+	2	386	c.217C>G	c.(217-219)CTG>GTG	p.L73V	KCNK2_uc001hko.2_Missense_Mutation_p.L69V|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.L58V	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	73	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TGTCCTCTATCTGATCATCGG	0.483													0	0	0	0.189662	0	17	29										G	215259881	C	G	215259881	3	3	37	1	0	0	0	0	1	0	0	0	8066	912	32	1	266	1	KCNK2	1	215259881	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3508416	215259881	33990740	34	9043										
LBR	3930	broad.mit.edu	37	chr1	225598067	225598067	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	catggccaaggatggaacagCgcggtcctgtattttcattt	11	9	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:225598067C>T	uc001hoy.2	-	10	1383	c.1240G>A	c.(1240-1242)GCT>ACT	p.A414T	LBR_uc001hoz.2_Missense_Mutation_p.A414T|LBR_uc001hpa.1_Missense_Mutation_p.A414T	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	414					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		GATGGAACAGCGCGGTCCTGT	0.358													0	0	0	0.069288	0	16	69										T	225598067	C	T	225598067	3	4	37	1	0	0	0	0	1	0	0	0	8652	768	27	2	627	2	LBR	1	225598067	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10338186	225598067	23652554	35	9044										
LYST	1130	broad.mit.edu	37	chr1	235973651	235973651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gctgtgtctttcttgcatctCttacagaatagcgatgggta	10	8	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:235973651C>G	uc001hxj.2	-	5	642	c.467G>C	c.(466-468)AGA>ACA	p.R156T	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R156T	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	156					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTTGCATCTCTTACAGAATA	0.418									Chediak-Higashi_syndrome				0	0	0	0.193644	0	30	42										G	235973651	C	G	235973651	3	3	37	1	0	0	0	0	1	0	0	0	9128	913	32	1	11134	1	LYST	1	235973651	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10375584	235973651	13276970	36	9045										
FMN2	56776	broad.mit.edu	37	chr1	240255687	240255687	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggggaaaggcgccggcggctCccgcgaagatgtactggatt	17	10	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:240255687C>T	uc010pyd.1	+	1	503	c.278C>T	c.(277-279)TCC>TTC	p.S93F	FMN2_uc010pye.1_Missense_Mutation_p.S93F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	93					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCGGCGGCTCCCGCGAAGAT	0.617													0	0	0	0.069234	0	9	27										T	240255687	C	T	240255687	3	4	37	1	0	0	0	0	1	0	0	0	5950	855	30	1	280	1	FMN2	1	240255687	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4282036	240255687	8994934	37	9046										
FMN2	56776	broad.mit.edu	37	chr1	240255999	240255999	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggagcaagaggatttgctttCagacatccagcaggcgatcc	12	10	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:240255999C>G	uc010pyd.1	+	1	815	c.590C>G	c.(589-591)TCA>TGA	p.S197*	FMN2_uc010pye.1_Nonsense_Mutation_p.S197*	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	197	Potential.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GATTTGCTTTCAGACATCCAG	0.413													0	0	0	0.038147	0	7	38										G	240255999	C	G	240255999	4	3	37	1	0	0	0	0	0	1	0	0	5950	838	29	1	592	1	FMN2	1	240255999	Nonsense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	312	240255999	8994622	38	9047										
LPIN1	23175	broad.mit.edu	37	chr2	11964910	11964910	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccaggacattcattctgcctCagcgtaaaatgtcccaagca	7	13	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:11964910C>T	uc010yjn.1	+	21	2940	c.2666C>T	c.(2665-2667)TCA>TTA	p.S889L	LPIN1_uc010yjm.1_Missense_Mutation_p.S974L|LPIN1_uc002rbt.2_Missense_Mutation_p.S889L|LPIN1_uc010yjo.1_Missense_Mutation_p.S390L	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	889					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CATTCTGCCTCAGCGTAAAAT	0.517													0	0	0	0.146539	0	12	35										T	11964910	C	T	11964910	3	4	37	1	0	0	0	0	1	0	0	0	8918	838	29	1	2740	1	LPIN1	2	11964910	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		11964910	231234463	39	9048										
TRIB2	28951	broad.mit.edu	37	chr2	12880633	12880633	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgatgctgtacaccatgttgGtggggcggtaccctttccat	12	10	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:12880633G>A	uc002rbv.3	+	3	2181	c.745G>A	c.(745-747)GTG>ATG	p.V249M	TRIB2_uc010yjp.1_Missense_Mutation_p.V113M	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	249	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CACCATGTTGGTGGGGCGGTA	0.582													0	0	0	0.080422	0	32	22										A	12880633	G	A	12880633	3	1	37	1	0	0	0	0	1	0	0	0	16480	1261	44	2	755	2	TRIB2	2	12880633	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	915723	12880633	230318740	40	9049										
APOB	338	broad.mit.edu	37	chr2	21224807	21224807	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aaaaatcttgcagtttatatCtaaactgctggtggtaatca	7	6	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:21224807C>G	uc002red.2	-	29	13615	c.13487G>C	c.(13486-13488)AGA>ACA	p.R4496T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4496					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGTTTATATCTAAACTGCTG	0.363													0	0	0	0.080935	0	11	38										G	21224807	C	G	21224807	3	3	37	1	0	0	0	0	1	0	0	0	785	913	32	1	208	1	APOB	2	21224807	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	8344174	21224807	221974566	41	9050										
C2orf16	84226	broad.mit.edu	37	chr2	27800241	27800241	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatatgaagggattactccgGaactcaagcattactttaca	7	8	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:27800241G>A	uc002rkz.3	+	1	853	c.802G>A	c.(802-804)GAA>AAA	p.E268K		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	268										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GATTACTCCGGAACTCAAGCA	0.463													0	0	0	0.193644	0	27	37										A	27800241	G	A	27800241	3	1	37	1	0	0	0	0	1	0	0	0	2157	1175	41	1	804	1	C2orf16	2	27800241	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	6575434	27800241	215399132	42	9051										
PLEKHH2	130271	broad.mit.edu	37	chr2	43991401	43991401	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctatgtgtacaagagtctaaTgacctttggaggctatcaag	10	7	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:43991401T>C	uc010yny.1	+	29	4276	c.4193T>C	c.(4192-4194)ATG>ACG	p.M1398T		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1398	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAGAGTCTAATGACCTTTGGA	0.328													0	0	0	0.189662	0	16	19										C	43991401	T	C	43991401	3	2	37	1	0	0	0	0	1	0	0	0	12077	1464	51	5	4303	5	PLEKHH2	2	43991401	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	16191160	43991401	199207972	43	9052										
RHOQ	23433	broad.mit.edu	37	chr2	46770291	46770291	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atgccaacgacgccttcccgGaggagtacgtgcccaccgtc	11	16	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:46770291G>A	uc002rva.2	+	1	425	c.106G>A	c.(106-108)GAG>AAG	p.E36K	ATP6V1E2_uc002ruz.2_5'Flank	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	36					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGCCTTCCCGGAGGAGTACGT	0.652													0	0	0	0.139131	0	51	172										A	46770291	G	A	46770291	3	1	37	1	0	0	0	0	1	0	0	0	13342	1175	41	1	108	1	RHOQ	2	46770291	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2778890	46770291	196429082	44	9053										
NRXN1	9378	broad.mit.edu	37	chr2	50733744	50733744	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atagccagcaaaaagagtctCgggacctttgcctgtagaat	10	9	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:50733744C>G	uc010fbq.2	-	13	3983	c.2506G>C	c.(2506-2508)GAG>CAG	p.E836Q	NRXN1_uc002rxb.3_Missense_Mutation_p.E468Q|NRXN1_uc002rxe.3_Missense_Mutation_p.E796Q|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAAGAGTCTCGGGACCTTTG	0.378													0	0	0	0.069234	0	9	19										G	50733744	C	G	50733744	3	3	37	1	0	0	0	0	1	0	0	0	10665	893	31	1	2444	1	NRXN1	2	50733744	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3963453	50733744	192465629	45	9054										
KIAA1841	84542	broad.mit.edu	37	chr2	61333734	61333734	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctctgtgatgaaaagggtatAgaatgtgatgttttactgga	12	3	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:61333734A>G	uc002saw.3	+	14	1851	c.1548A>G	c.(1546-1548)ATA>ATG	p.I516M	KIAA1841_uc002sax.3_Missense_Mutation_p.I370M|KIAA1841_uc002say.2_Missense_Mutation_p.I516M	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	516											0			Epithelial(17;0.193)			AAAAGGGTATAGAATGTGATG	0.348													0	0	0	0.0918	0	18	45										G	61333734	A	G	61333734	3	3	37	1	0	0	0	0	1	0	0	0	8261	410	15	5	1594	5	KIAA1841	2	61333734	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	10599990	61333734	181865639	46	9055										
ATP6V1B1	525	broad.mit.edu	37	chr2	71187068	71187068	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tctgtgatcgccctctcccaGgccagcccatcaacccgcac	7	20	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:71187068G>A	uc002shj.2	+	6	533	c.446_splice	c.e6-1	p.G149_splice	ATP6V1B1_uc002shi.1_Splice_Site_p.G149_splice|ATP6V1B1_uc010fdv.2_Splice_Site_p.G149_splice|ATP6V1B1_uc010fdw.2_Splice_Site|ATP6V1B1_uc010fdx.2_Splice_Site_p.G107_splice	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1						ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CCCTCTCCCAGGCCAGCCCAT	0.547													0	0	0	0.092188	0	30	103										A	71187068	G	A	71187068	5	1	37	1	0	0	0	0	0	0	1	0	1178	1014	35	2	467	2	ATP6V1B1	2	71187068	Splice_Site	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	9853334	71187068	172012305	47	9056										
CNTNAP5	129684	broad.mit.edu	37	chr2	125261952	125261952	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggcagctatttgctgctgccCggcaccccccaaattgatgg	11	14	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:125261952C>T	uc002tno.2	+	8	1507	c.1143C>T	c.(1141-1143)CCC>CCT	p.P381P	CNTNAP5_uc010flu.2_Silent_p.P382P	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	381	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGCTGCTGCCCGGCACCCCCC	0.512													0	0	0	0.139131	0	42	25										T	125261952	C	T	125261952	2	4	37	1	0	0	0	0	0	0	0	1	3650	639	23	2		2	CNTNAP5	2	125261952	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	54074884	125261952	117937421	48	9057										
THSD7B	80731	broad.mit.edu	37	chr2	137928489	137928489	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggacatcgtattctgaaggcCgtctgccagaatgaccgcgg	13	11	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:137928489C>T	uc002tva.1	+	6	1611	c.1611C>T	c.(1609-1611)GCC>GCT	p.A537A	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.A427A	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTCTGAAGGCCGTCTGCCAGA	0.483													0	0	0	0.160694	0	11	12										T	137928489	C	T	137928489	2	4	37	1	0	0	0	0	0	0	0	1	15877	639	23	2		2	THSD7B	2	137928489	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	12666537	137928489	105270884	49	9058										
LYPD6B	130576	broad.mit.edu	37	chr2	150071149	150071149	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tttgccgtaatgcacgctcaGagaacatctggcagcagtgc	11	11	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:150071149G>A	uc002twv.1	+	7	950	c.549G>A	c.(547-549)CAG>CAA	p.Q183Q	LYPD6B_uc002tww.1_Silent_p.Q145Q|LYPD6B_uc002twx.1_Silent_p.Q145Q	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	159						anchored to membrane|plasma membrane					0						TGCACGCTCAGAGAACATCTG	0.493													0	0	0	0.139131	0	63	148										A	150071149	G	A	150071149	2	1	37	1	0	0	0	0	0	0	0	1	9115	933	33	1		1	LYPD6B	2	150071149	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	12142660	150071149	93128224	50	9059										
TTN	7273	broad.mit.edu	37	chr2	179610636	179610636	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aaactgtctgtgtagttgctCtttaagaccaattcttccat	6	9	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:179610636C>G	uc002unb.2	-	46	16715	c.16491G>C	c.(16489-16491)AAG>AAC	p.K5497N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAGTTGCTCTTTAAGACCA	0.408													0	0	0	0.189662	0	15	44										G	179610636	C	G	179610636	3	3	37	1	0	0	0	0	1	0	0	0	16732	912	32	1	93806	1	TTN	2	179610636	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	29539487	179610636	63588737	51	9060										
FAM171B	165215	broad.mit.edu	37	chr2	187627410	187627410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	accctggagaagagtcgccaGgaaggaaaagcactgttgaa	13	8	0	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:187627410G>A	uc002ups.2	+	8	2453	c.2341G>A	c.(2341-2343)GGA>AGA	p.G781R	FAM171B_uc002upr.1_Missense_Mutation_p.G748R|FAM171B_uc002upt.2_Missense_Mutation_p.G250R	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	781	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AGAGTCGCCAGGAAGGAAAAG	0.502													0	0	0	0.150653	0	3	18										A	187627410	G	A	187627410	3	1	37	1	0	0	0	0	1	0	0	0	5491	1001	35	2	2371	2	FAM171B	2	187627410	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	8016774	187627410	55571963	52	9061										
ALS2CR11	151254	broad.mit.edu	37	chr2	202400897	202400897	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgcctgcttttattgtttcCtggttagaaatagtgcacaa	8	8	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:202400897C>T	uc002uye.2	-	13	1401	c.1353G>A	c.(1351-1353)CAG>CAA	p.Q451Q	ALS2CR11_uc002uyf.2_Silent_p.Q451Q|ALS2CR11_uc010fti.2_Intron	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	451										large_intestine(1)|ovary(1)|skin(1)	3						TTATTGTTTCCTGGTTAGAAA	0.373													0	0	0	0.047766	0	8	55										T	202400897	C	T	202400897	2	4	37	1	0	0	0	0	0	0	0	1	552	680	24	2		2	ALS2CR11	2	202400897	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	14773487	202400897	40798476	53	9062										
INO80D	54891	broad.mit.edu	37	chr2	206882469	206882469	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtcaaaaactggcacagagcActgctgtccatctgcaaact	8	12	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:206882469A>C	uc002vaz.3	-	8	1882	c.1477T>G	c.(1477-1479)TGC>GGC	p.C493G		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	493					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GGCACAGAGCACTGCTGTCCA	0.373													0	0	0	0.069234	0	9	11										C	206882469	A	C	206882469	3	2	37	1	0	0	0	0	1	0	0	0	7749	159	6	5	1622	5	INO80D	2	206882469	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	4481572	206882469	36316904	54	9063										
TNS1	7145	broad.mit.edu	37	chr2	218700908	218700908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagaggggctgggggctctgCaggctgcttctcccgagcct	16	13	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:218700908C>T	uc002vgt.2	-	18	3057	c.2659G>A	c.(2659-2661)GCA>ACA	p.A887T	TNS1_uc002vgr.2_Missense_Mutation_p.A887T|TNS1_uc002vgs.2_Missense_Mutation_p.A887T|TNS1_uc010zjv.1_Missense_Mutation_p.A887T	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	887						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGGGGCTCTGCAGGCTGCTTC	0.582													0	0	0	0.047766	0	6	51										T	218700908	C	T	218700908	3	4	37	1	0	0	0	0	1	0	0	0	16340	710	25	2	2612	2	TNS1	2	218700908	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	11818439	218700908	24498465	55	9064										
SH3BP4	23677	broad.mit.edu	37	chr2	235943684	235943684	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccgagcggccaactccaatgGcctccctcgctgcaagtcag	10	17	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:235943684G>A	uc002vvp.2	+	3	431	c.38G>A	c.(37-39)GGC>GAC	p.G13D	SH3BP4_uc010fym.2_Missense_Mutation_p.G13D|SH3BP4_uc002vvq.2_Missense_Mutation_p.G13D	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	13					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AACTCCAATGGCCTCCCTCGC	0.552													0	0	0	0.021553	0	5	30										A	235943684	G	A	235943684	3	1	37	1	0	0	0	0	1	0	0	0	14246	1203	42	2	40	2	SH3BP4	2	235943684	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	17242776	235943684	7255689	56	9065										
ITPR1	3708	broad.mit.edu	37	chr3	4711438	4711438	+	Missense_Mutation	SNP	G	G	A													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgctgaaccccaccaacgctGacatcctgattgagaccaag							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:4711438G>A	uc003bqa.2	+	19	2335	c.1987G>A	c.(1987-1989)GAC>AAC	p.D663N	ITPR1_uc010hca.1_Missense_Mutation_p.D648N|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.D648N	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	663	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CACCAACGCTGACATCCTGAT	0.468													0	0	0	0.02938	0	6	13										A	4711438	G	A	4711438	3	1	37	1	0	0	0	0	1	0	0	0	7920	1290	45	1	2053	1	ITPR1	3	4711438	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		4711438	193310992	57	9066	44	2								
ITPR1	3708	broad.mit.edu	37	chr3	4711446	4711446	+	Silent	SNP	G	G	A													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cccaccaacgctgacatcctGattgagaccaagtgagtggg							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:4711446G>A	uc003bqa.2	+	19	2343	c.1995G>A	c.(1993-1995)CTG>CTA	p.L665L	ITPR1_uc010hca.1_Silent_p.L650L|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Silent_p.L650L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	665	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGACATCCTGATTGAGACCA	0.463													0	0	0	0.184627	0	5	12										A	4711446	G	A	4711446	2	1	37	1	0	0	0	0	0	0	0	1	7920	1277	45	1		1	ITPR1	3	4711446	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	8	4711446	193310984	58	9067	44	2								
ALAS1	211	broad.mit.edu	37	chr3	52245397	52245397	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcttcatcttcaccacctctCtgccacccatgctgctggct	6	18	4	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:52245397C>G	uc003dcy.1	+	10	1766	c.1429C>G	c.(1429-1431)CTG>GTG	p.L477V	ALAS1_uc003dcz.1_Missense_Mutation_p.L477V|ALAS1_uc011bec.1_Missense_Mutation_p.L494V	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	477					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CACCACCTCTCTGCCACCCAT	0.592													0	0	0	0.055883	0	20	9										G	52245397	C	G	52245397	3	3	37	1	0	0	0	0	1	0	0	0	484	912	32	1	1459	1	ALAS1	3	52245397	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	47533951	52245397	145777033	59	9068										
FAM19A4	151647	broad.mit.edu	37	chr3	68802156	68802156	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acctcacaggtcccttgcttGatttggtggtgacctagttg	11	10	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:68802156G>C	uc003dnh.1	-	4	587	c.144C>G	c.(142-144)ATC>ATG	p.I48M	FAM19A4_uc003dni.1_Missense_Mutation_p.I48M	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	48						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TCCCTTGCTTGATTTGGTGGT	0.493													0	0	0	0.144211	0	23	10										C	68802156	G	C	68802156	3	2	37	1	0	0	0	0	1	0	0	0	5534	1280	45	1	290	1	FAM19A4	3	68802156	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	16556759	68802156	129220274	60	9069										
CADM2	253559	broad.mit.edu	37	chr3	86010686	86010686	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgaccgaatggttgtgagtGgtagggagctaaacattctt	13	6	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:86010686G>C	uc003dqj.2	+	7	1458	c.832G>C	c.(832-834)GGT>CGT	p.G278R	CADM2_uc003dqk.2_Missense_Mutation_p.G287R|CADM2_uc003dql.2_Missense_Mutation_p.G280R	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	278	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GGTTGTGAGTGGTAGGGAGCT	0.433													0	0	0	0.163468	0	26	83										C	86010686	G	C	86010686	3	2	37	1	0	0	0	0	1	0	0	0	2567	1348	47	4	929	4	CADM2	3	86010686	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	17208530	86010686	112011744	61	9070										
NSUN3	63899	broad.mit.edu	37	chr3	93802971	93802971	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggagatactaacatctccatCatgctggcaatatgctgtcc	8	11	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:93802971C>G	uc003drl.1	+	3	259	c.143C>G	c.(142-144)TCA>TGA	p.S48*		NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	48							methyltransferase activity			skin(1)	1						ACATCTCCATCATGCTGGCAA	0.338													0	0	0	0.099896	0	23	24										G	93802971	C	G	93802971	4	3	37	1	0	0	0	0	0	1	0	0	10679	838	29	1	153	1	NSUN3	3	93802971	Nonsense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	7792285	93802971	104219459	62	9071										
BBX	56987	broad.mit.edu	37	chr3	107520009	107520009	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gagacagactgcaatgacaaAtgctcacacaacaccgaggt	9	11	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:107520009A>G	uc010hpr.2	+	17	2946	c.2619A>G	c.(2617-2619)AAA>AAG	p.K873K	BBX_uc003dwk.3_Silent_p.K843K|BBX_uc003dwl.3_Missense_Mutation_p.N537S|BBX_uc003dwm.3_Silent_p.K843K|BBX_uc003dwo.3_Missense_Mutation_p.N190S	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCAATGACAAATGCTCACACA	0.512													0	0	0	0.139131	0	43	32										G	107520009	A	G	107520009	2	3	37	1	0	0	0	0	0	0	0	1	1343	98	4	5		5	BBX	3	107520009	Silent	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	13717038	107520009	90502421	63	9072										
RPN1	6184	broad.mit.edu	37	chr3	128356705	128356705	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aggtcctcagagcgcgtgggGttccccagcttggtgtagct	15	11	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:128356705G>A	uc003ekr.1	-	3	646	c.570C>T	c.(568-570)AAC>AAT	p.N190N	RPN1_uc011bkq.1_Silent_p.N18N	NM_002950	NP_002941	P04843	RPN1_HUMAN	ribophorin I precursor	190	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(114;0.189)		AGCGCGTGGGGTTCCCCAGCT	0.532			T	EVI1	AML								0	0	0	0.108266	0	23	83										A	128356705	G	A	128356705	2	1	37	1	0	0	0	0	0	0	0	1	13607	1252	44	2		2	RPN1	3	128356705	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	20836696	128356705	69665725	64	9073										
RNF7	9616	broad.mit.edu	37	chr3	141462354	141462354	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tatttgtttacttttagatgCctgtcttagatgtcaagctg	8	6	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:141462354C>T	uc003eud.2	+	2	312	c.179C>T	c.(178-180)GCC>GTC	p.A60V	RNF7_uc003euc.2_Missense_Mutation_p.P58S|RNF7_uc003eue.2_RNA	NM_014245	NP_055060	Q9UBF6	RBX2_HUMAN	ring finger protein 7 isoform 1	60					anti-apoptosis|induction of apoptosis by oxidative stress|protein neddylation|response to redox state	cytoplasm|nucleus	copper ion binding|NEDD8 ligase activity|protein binding|zinc ion binding				0						CTTTTAGATGCCTGTCTTAGA	0.373													0	0	0	0.204396	0	16	35										T	141462354	C	T	141462354	3	4	37	1	0	0	0	0	1	0	0	0	13499	739	26	2	185	2	RNF7	3	141462354	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	13105649	141462354	56560076	65	9074										
MAP3K13	9175	broad.mit.edu	37	chr3	185155308	185155308	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggagcccaaggagcggtcttCttgggcaagttccgggcgga	17	10	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:185155308C>T	uc010hyf.2	+	4	815	c.549C>T	c.(547-549)TTC>TTT	p.F183F	MAP3K13_uc011brt.1_Intron|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Silent_p.F39F|MAP3K13_uc003fpi.2_Silent_p.F183F|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	183	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAGCGGTCTTCTTGGGCAAGT	0.498													0	0	0	0.139131	0	49	89										T	185155308	C	T	185155308	2	4	37	1	0	0	0	0	0	0	0	1	9247	912	32	1		1	MAP3K13	3	185155308	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	43692954	185155308	12867122	66	9075										
DGKG	1608	broad.mit.edu	37	chr3	186006603	186006603	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agcttgaagaccgagggacgGggggttccaggggggtcgca	20	8	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:186006603G>A	uc003fqa.2	-	6	977	c.440C>T	c.(439-441)CCC>CTC	p.P147L	DGKG_uc003fqb.2_Missense_Mutation_p.P147L|DGKG_uc003fqc.2_Missense_Mutation_p.P147L|DGKG_uc011brx.1_Missense_Mutation_p.P147L	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	147					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCGAGGGACGGGGGGTTCCAG	0.547													0	0	0	0.139131	0	100	310										A	186006603	G	A	186006603	3	1	37	1	0	0	0	0	1	0	0	0	4469	1232	43	2	2015	2	DGKG	3	186006603	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	851295	186006603	12015827	67	9076										
OPA1	4976	broad.mit.edu	37	chr3	193384092	193384092	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cttaatatttcagttggaatGcaatgatgtggtcttgtttt	9	4	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:193384092G>C	uc003ftm.2	+	26	2855	c.2621G>C	c.(2620-2622)TGC>TCC	p.C874S	OPA1_uc003ftg.2_Missense_Mutation_p.C929S|OPA1_uc003fth.2_Missense_Mutation_p.C893S|OPA1_uc003fti.2_Missense_Mutation_p.C911S|OPA1_uc003ftj.2_Missense_Mutation_p.C892S|OPA1_uc003ftk.2_Missense_Mutation_p.C875S|OPA1_uc003ftl.2_Missense_Mutation_p.C856S|OPA1_uc003ftn.2_Missense_Mutation_p.C838S	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	874	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CAGTTGGAATGCAATGATGTG	0.358													0	0	0	0.0918	0	21	56										C	193384092	G	C	193384092	3	2	37	1	0	0	0	0	1	0	0	0	10871	1319	46	4	2896	4	OPA1	3	193384092	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	7377489	193384092	4638338	68	9077										
SENP5	205564	broad.mit.edu	37	chr3	196613169	196613169	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gggagtgtacagagctgattCatgacatccccttaccagaa	10	10	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:196613169C>T	uc003fwz.3	+	2	1366	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	SENP5_uc011bty.1_Missense_Mutation_p.H373Y	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	373					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGAGCTGATTCATGACATCCC	0.443													0	0	0	0.058154	0	6	38										T	196613169	C	T	196613169	3	4	37	1	0	0	0	0	1	0	0	0	14049	826	29	1	1119	1	SENP5	3	196613169	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3229077	196613169	1409261	69	9078										
DLG1	1739	broad.mit.edu	37	chr3	196792639	196792639	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caagtcatcatttatcctgtCtttcataggtcccaatatga	5	10	4	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:196792639C>G	uc003fxo.3	-	22	2363	c.2173G>C	c.(2173-2175)GAC>CAC	p.D725H	DLG1_uc011bub.1_Missense_Mutation_p.D621H|DLG1_uc011buc.1_Missense_Mutation_p.D609H|DLG1_uc011bud.1_Missense_Mutation_p.D408H|DLG1_uc003fxn.3_Missense_Mutation_p.D747H|DLG1_uc011bue.1_Missense_Mutation_p.D713H|DLG1_uc010ial.2_Missense_Mutation_p.D725H	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	725	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TTTATCCTGTCTTTCATAGGT	0.299													0	0	0	0.175082	0	12	42										G	196792639	C	G	196792639	3	3	37	1	0	0	0	0	1	0	0	0	4554	913	32	1	561	1	DLG1	3	196792639	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	179470	196792639	1229791	70	9079										
ZNF721	170960	broad.mit.edu	37	chr4	436766	436766	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aacattcaaagggtttctcgCcagtatgaatcctcttatgt	7	9	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:436766C>A	uc003gag.2	-	3	2181	c.1490G>T	c.(1489-1491)GGC>GTC	p.G497V	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.G529V|ZNF721_uc010ibe.2_Missense_Mutation_p.G485V	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	497						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GGGTTTCTCGCCAGTATGAAT	0.383													1	0	9.31168e-06	0.105934	9.54447e-06	11	41										A	436766	C	A	436766	3	1	37	1	0	0	0	0	1	0	0	0	18119	739	26	4	1285	4	ZNF721	4	436766	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		436766	190717510	71	9080										
NMU	10874	broad.mit.edu	37	chr4	56475309	56475309	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaggctttggtagcattcccAtaatcataaagcaaagctcc	8	10	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:56475309A>G	uc003hbc.2	-	4	363	c.257T>C	c.(256-258)ATG>ACG	p.M86T	NMU_uc003hbd.1_RNA|NMU_uc010igv.1_RNA|NMU_uc010igw.1_Missense_Mutation_p.M1T|NMU_uc010igx.1_RNA	NM_006681	NP_006672	P48645	NMU_HUMAN	neuromedin U precursor	86					neuropeptide signaling pathway	extracellular region					0	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		TAGCATTCCCATAATCATAAA	0.358													0	0	0	0.139131	0	41	24										G	56475309	A	G	56475309	3	3	37	1	0	0	0	0	1	0	0	0	10505	217	8	5	291	5	NMU	4	56475309	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	56038543	56475309	134678967	72	9081										
EXOC1	55763	broad.mit.edu	37	chr4	56734667	56734667	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctttgcagaaaaattgtccaGagagctgcaggtgctagatg	12	7	0	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:56734667G>C	uc003hbe.1	+	5	739	c.581G>C	c.(580-582)AGA>ACA	p.R194T	EXOC1_uc003hbf.1_Missense_Mutation_p.R194T|EXOC1_uc003hbg.1_Missense_Mutation_p.R194T	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	194					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AAATTGTCCAGAGAGCTGCAG	0.388													0	0	0	0.080935	0	9	49										C	56734667	G	C	56734667	3	2	37	1	0	0	0	0	1	0	0	0	5301	942	33	1	595	1	EXOC1	4	56734667	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	259358	56734667	134419609	73	9082										
AFF1	4299	broad.mit.edu	37	chr4	88052994	88052994	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atgccacagcgccaacacaaGagaaaatatttgctgtttta	7	9	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:88052994G>C	uc003hqj.3	+	17	3537	c.3130G>C	c.(3130-3132)GAG>CAG	p.E1044Q	AFF1_uc011ccz.1_Missense_Mutation_p.E1051Q|AFF1_uc003hqk.3_Missense_Mutation_p.E1044Q|AFF1_uc011cda.1_Missense_Mutation_p.E682Q	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1044						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCCAACACAAGAGAAAATATT	0.308													0	0	0	0.150653	0	3	14										C	88052994	G	C	88052994	3	2	37	1	0	0	0	0	1	0	0	0	356	943	33	1	3238	1	AFF1	4	88052994	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	31318327	88052994	103101282	74	9083										
NDST3	9348	broad.mit.edu	37	chr4	119158371	119158371	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agaccgagcatactcctggtAccaggtaaggaaaatgcaaa	10	9	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:119158371A>G	uc003ibx.2	+	10	2517	c.2114A>G	c.(2113-2115)TAC>TGC	p.Y705C	NDST3_uc011cgf.1_3'UTR	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	705	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TACTCCTGGTACCAGGTAAGG	0.443													0	0	0	0.09319	0	8	35										G	119158371	A	G	119158371	3	3	37	1	0	0	0	0	1	0	0	0	10257	391	14	5	2148	5	NDST3	4	119158371	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	31105377	119158371	71995905	75	9084										
SPATA5	166378	broad.mit.edu	37	chr4	124177235	124177235	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tttaccggatgcagcaacaaGaagggaaatatttaagctgc	10	7	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:124177235G>A	uc003iez.3	+	15	2478	c.2405G>A	c.(2404-2406)AGA>AAA	p.R802K		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	802					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						GCAGCAACAAGAAGGGAAATA	0.438													0	0	0	0.139131	0	42	15										A	124177235	G	A	124177235	3	1	37	1	0	0	0	0	1	0	0	0	15010	942	33	1	2463	1	SPATA5	4	124177235	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	5018864	124177235	66977041	76	9085										
NAA15	80155	broad.mit.edu	37	chr4	140299981	140299981	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctagtcatccctggcttcatGagtgtatgattcgtctcttt	8	10	3	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:140299981G>A	uc003ihu.1	+	17	2384	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	710					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						CTGGCTTCATGAGTGTATGAT	0.328													0	0	0	0.108266	0	20	14										A	140299981	G	A	140299981	3	1	37	1	0	0	0	0	1	0	0	0	10118	1291	45	1	2194	1	NAA15	4	140299981	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	16122746	140299981	50854295	77	9086										
ADAM29	11086	broad.mit.edu	37	chr4	175896737	175896737	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgtcctgttctggacacatcCaggatgagcacccccaatat	8	13	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:175896737C>A	uc003iuc.2	+	5	731	c.61C>A	c.(61-63)CAG>AAG	p.Q21K	ADAM29_uc003iud.2_Missense_Mutation_p.Q21K|ADAM29_uc010irr.2_Missense_Mutation_p.Q21K|ADAM29_uc011cki.1_Missense_Mutation_p.Q21K	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	21					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGGACACATCCAGGATGAGCA	0.507													1	0	1.96895e-08	0.076483	2.03086e-08	20	75										A	175896737	C	A	175896737	3	1	37	1	0	0	0	0	1	0	0	0	247	595	21	4	63	4	ADAM29	4	175896737	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	35596756	175896737	15257539	78	9087										
ODZ3	55714	broad.mit.edu	37	chr4	183245337	183245337	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agcttttgatcatgattcctCgcggctgctttacggcaaca	9	11	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:183245337C>T	uc003ivd.1	+	1	201	c.164C>T	c.(163-165)TCG>TTG	p.S55L	ODZ3_uc010irv.1_Missense_Mutation_p.S55L	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	55	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CATGATTCCTCGCGGCTGCTT	0.483													0	0	0	0.069288	0	20	57										T	183245337	C	T	183245337	3	4	37	1	0	0	0	0	1	0	0	0	10836	893	31	1	166	1	ODZ3	4	183245337	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	7348600	183245337	7908939	79	9088										
SEMA5A	9037	broad.mit.edu	37	chr5	9190395	9190395	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctacctgtggccaaatagatGatgtggacgagcgcttctct	11	10	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:9190395G>T	uc003jek.2	-	11	1969	c.1257C>A	c.(1255-1257)ATC>ATA	p.I419I		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	419	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCAAATAGATGATGTGGACGA	0.498													1	0	0.000442599	0.058154	0.000446685	8	34										T	9190395	G	T	9190395	2	4	37	1	0	0	0	0	0	0	0	1	14037	1280	45	3		3	SEMA5A	5	9190395	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		9190395	171724865	80	9089										
NUP155	9631	broad.mit.edu	37	chr5	37292081	37292081	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgctactgacgagctcataGactggagctcaacaaggtaa	10	10	2	2	rs140076285	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:37292081G>C	uc003jku.1	-	35	4215	c.4097C>G	c.(4096-4098)TCT>TGT	p.S1366C	NUP155_uc003jkt.1_Missense_Mutation_p.S1307C|NUP155_uc010iuz.1_Missense_Mutation_p.S1302C	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1366					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGAGCTCATAGACTGGAGCTC	0.363													0	0	0	0.055883	0	18	47										C	37292081	G	C	37292081	3	2	37	1	0	0	0	0	1	0	0	0	10756	942	33	1	82	1	NUP155	5	37292081	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	28101686	37292081	143623179	81	9090										
MAP1B	4131	broad.mit.edu	37	chr5	71494257	71494257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgaagtggactacagtccttCtgacatgcaggactccagtt	10	10	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:71494257C>G	uc003kbw.3	+	5	5316	c.5075C>G	c.(5074-5076)TCT>TGT	p.S1692C	MAP1B_uc010iyw.1_Missense_Mutation_p.S1709C|MAP1B_uc010iyx.1_Missense_Mutation_p.S1566C|MAP1B_uc010iyy.1_Missense_Mutation_p.S1566C	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1692						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TACAGTCCTTCTGACATGCAG	0.488													0	0	0	0.183431	0	33	16										G	71494257	C	G	71494257	3	3	37	1	0	0	0	0	1	0	0	0	9228	913	32	1	5093	1	MAP1B	5	71494257	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	34202176	71494257	109421003	82	9091										
TNPO1	3842	broad.mit.edu	37	chr5	72189254	72189254	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gctccagataaagattttatGatagtggctcttgatttact	8	6	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:72189254G>A	uc003kck.3	+	17	2094	c.1947G>A	c.(1945-1947)ATG>ATA	p.M649I	TNPO1_uc011csj.1_Missense_Mutation_p.M599I|TNPO1_uc003kch.2_Missense_Mutation_p.M641I|TNPO1_uc003kci.3_Missense_Mutation_p.M641I|TNPO1_uc003kcg.3_Missense_Mutation_p.M641I	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	649					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		AAGATTTTATGATAGTGGCTC	0.378													0	0	0	0.184627	0	4	25										A	72189254	G	A	72189254	3	1	37	1	0	0	0	0	1	0	0	0	16332	1290	45	1	2013	1	TNPO1	5	72189254	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	694997	72189254	108726006	83	9092										
CMYA5	202333	broad.mit.edu	37	chr5	79026793	79026793	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tacatgattccatcagaagaGaaggaagacactggatcgtt	10	7	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:79026793G>A	uc003kgc.2	+	2	2277	c.2205G>A	c.(2203-2205)GAG>GAA	p.E735E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	735						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CATCAGAAGAGAAGGAAGACA	0.463													0	0	0	0.175082	0	13	49										A	79026793	G	A	79026793	2	1	37	1	0	0	0	0	0	0	0	1	3590	933	33	1		1	CMYA5	5	79026793	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	6837539	79026793	101888467	84	9093										
GPR98	84059	broad.mit.edu	37	chr5	90078972	90078972	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gttgggctgatcatgatcccAgtggtgaggctacatggaac	14	8	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:90078972A>G	uc003kju.2	+	66	13359	c.13263A>G	c.(13261-13263)CCA>CCG	p.P4421P	GPR98_uc003kjt.2_Silent_p.P2127P|GPR98_uc003kjw.2_Silent_p.P82P	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4421	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCATGATCCCAGTGGTGAGGC	0.448													0	0	0	0.139131	0	43	168										G	90078972	A	G	90078972	2	3	37	1	0	0	0	0	0	0	0	1	6721	175	7	5		5	GPR98	5	90078972	Silent	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	11052179	90078972	90836288	85	9094										
CAST	831	broad.mit.edu	37	chr5	96090429	96090429	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aacaattcctcctgattataGattagaagaggtcaaggtaa	8	6	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:96090429G>A	uc003klz.1	+	20	1607	c.1445G>A	c.(1444-1446)AGA>AAA	p.R482K	CAST_uc003klt.2_Missense_Mutation_p.R469K|CAST_uc003klu.2_Missense_Mutation_p.R565K|CAST_uc003klv.2_Missense_Mutation_p.R543K|CAST_uc003klw.2_Missense_Mutation_p.R546K|CAST_uc003klx.2_Missense_Mutation_p.R524K|CAST_uc003kly.2_Missense_Mutation_p.R530K|CAST_uc011cuo.1_Missense_Mutation_p.R528K|CAST_uc011cuq.1_Missense_Mutation_p.R330K|CAST_uc011cur.1_Missense_Mutation_p.R468K|CAST_uc011cus.1_Missense_Mutation_p.R469K|CAST_uc003kma.1_Missense_Mutation_p.R441K|CAST_uc011cut.1_Missense_Mutation_p.R410K|CAST_uc003kmb.2_Missense_Mutation_p.R428K|CAST_uc003kmc.2_Missense_Mutation_p.R482K|CAST_uc003kmd.2_Missense_Mutation_p.R460K|CAST_uc003kme.2_Missense_Mutation_p.R441K|CAST_uc003kmf.2_Missense_Mutation_p.R447K|CAST_uc003kmh.2_Missense_Mutation_p.R197K|CAST_uc010jbj.2_Missense_Mutation_p.R197K|CAST_uc010jbk.2_Missense_Mutation_p.R197K|CAST_uc010jbl.1_Missense_Mutation_p.R205K|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.R205K|CAST_uc003kmk.2_5'Flank	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	482	Inhibitory domain 3.						calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		CCTGATTATAGATTAGAAGAG	0.348													0	0	0	0.047766	0	7	30										A	96090429	G	A	96090429	3	1	37	1	0	0	0	0	1	0	0	0	2684	942	33	1	1904	1	CAST	5	96090429	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	6011457	96090429	84824831	86	9095										
PCDHB1	29930	broad.mit.edu	37	chr5	140431442	140431442	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtatttgatatcaatgacaaTgccccagttttcctaaacaa	5	9	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140431442T>C	uc003lik.1	+	1	464	c.387T>C	c.(385-387)AAT>AAC	p.N129N		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	129	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAATGACAATGCCCCAGTTT	0.542													0	0	0	0.09319	0	11	15										C	140431442	T	C	140431442	2	2	37	1	0	0	0	0	0	0	0	1	11534	1461	51	5		5	PCDHB1	5	140431442	Silent	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	44341013	140431442	40483818	87	9096										
PCDHGA10	56106	broad.mit.edu	37	chr5	140794089	140794089	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atgctacaagtggcagatatCaatgacaacccacctacctt	6	12	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140794089C>T	uc003lkl.1	+	1	1347	c.1347C>T	c.(1345-1347)ATC>ATT	p.I449I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.I449I	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	449	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGATATCAATGACAACC	0.498													0	0	0	0.163468	0	27	113										T	140794089	C	T	140794089	2	4	37	1	0	0	0	0	0	0	0	1	11551	816	29	1		1	PCDHGA10	5	140794089	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	362647	140794089	40121171	88	9097										
PCDHGB7	56099	broad.mit.edu	37	chr5	140798381	140798381	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tagaaagatatacgataaacAtagaagcaaaagaccgagga	9	5	0	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140798381A>T	uc003lkn.1	+	1	1100	c.955A>T	c.(955-957)ATA>TTA	p.I319L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.I319L|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	319	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACGATAAACATAGAAGCAAA	0.398													0	0	0	0.02938	0	7	1										T	140798381	A	T	140798381	3	4	37	1	0	0	0	0	1	0	0	0	11568	217	8	5	957	5	PCDHGB7	5	140798381	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	4292	140798381	40116879	89	9098										
PCDH1	5097	broad.mit.edu	37	chr5	141233836	141233836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cgcccgcaggctcctgccctCctcggtcctggtaaggcacg	12	18	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:141233836C>T	uc003llp.2	-	5	3602	c.3485G>A	c.(3484-3486)GGA>GAA	p.G1162E		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CTCCTGCCCTCCTCGGTCCTG	0.677													0	0	0	0.02938	0	6	12										T	141233836	C	T	141233836	3	4	37	1	0	0	0	0	1	0	0	0	11506	855	30	1	232	1	PCDH1	5	141233836	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	435455	141233836	39681424	90	9099										
PCDH1	5097	broad.mit.edu	37	chr5	141244913	141244913	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcctgtccagtcgaagaagaCgcctcacaacttcgggcgcc	10	15	1	2	rs149443924		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:141244913C>T	uc003llq.2	-	3	1100	c.983G>A	c.(982-984)CGT>CAT	p.R328H	PCDH1_uc003llp.2_Missense_Mutation_p.R328H|PCDH1_uc011dbf.1_Missense_Mutation_p.R306H	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	328	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCGAAGAAGACGCCTCACAAC	0.537													0	0	0	0.139131	0	44	44										T	141244913	C	T	141244913	3	4	37	1	0	0	0	0	1	0	0	0	11506	536	19	2	2826	2	PCDH1	5	141244913	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	11077	141244913	39670347	91	9100										
GPR151	134391	broad.mit.edu	37	chr5	145894746	145894746	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caagccttccctgaactcttCcgacatcacaagaaaaatga	5	13	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:145894746C>T	uc003lod.1	-	1	931	c.931G>A	c.(931-933)GAA>AAA	p.E311K		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGAACTCTTCCGACATCACA	0.478													0	0	0	0.02938	0	7	8										T	145894746	C	T	145894746	3	4	37	1	0	0	0	0	1	0	0	0	6657	864	30	1	332	1	GPR151	5	145894746	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4649833	145894746	35020514	92	9101										
SLU7	10569	broad.mit.edu	37	chr5	159831861	159831861	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acagattcttccccagttatCtcatttataatacactcctc	2	13	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:159831861C>T	uc003lyg.2	-	14	1574	c.1419G>A	c.(1417-1419)GAG>GAA	p.E473E		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	473					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCAGTTATCTCATTTATAA	0.348													0	0	0	0.11911	0	11	11										T	159831861	C	T	159831861	2	4	37	1	0	0	0	0	0	0	0	1	14755	912	32	1		1	SLU7	5	159831861	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	13937115	159831861	21083399	93	9102										
FOXC1	2296	broad.mit.edu	37	chr6	1611802	1611803	+	In_Frame_Ins	INS	-	-	GGC													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cctccagcgcgggcagctcgINSggcggcggcggcggcggcgc					rs71807729		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:1611802_1611803insGGC	uc003mtp.2	+	1	1122_1123	c.1122_1123insGGC	c.(1120-1125)insGGC	p.380_381insG		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	380_381	Poly-Gly.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		cgggcagctcgggcggcggcgg	0.49																		4	5	---	---								GGC	1611803	-	GGC	1611802	7	5	37	1	0	1	1	0	0	0	0	0	5994	1103	39	0	1124	0	FOXC1	6	1611802	In_Frame_Ins	INS	-	TCGA-CU-A3KJ-01A-11D-A21A-08		1611802	169503265	94	9103										
MRS2	57380	broad.mit.edu	37	chr6	24416692	24416692	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tggagatcttggatgaggaaGagttgctagaagagctctgt	15	4	2	5			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:24416692G>C	uc003neb.2	+	7	909	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	MRS2_uc003nea.2_Missense_Mutation_p.E263Q|MRS2_uc011djl.1_Missense_Mutation_p.E266Q|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Missense_Mutation_p.E213Q|MRS2_uc003nec.2_Missense_Mutation_p.E140Q	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	263	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						GGATGAGGAAGAGTTGCTAGA	0.294													0	0	0	0.139131	0	41	7										C	24416692	G	C	24416692	3	2	37	1	0	0	0	0	1	0	0	0	9851	943	33	1	813	1	MRS2	6	24416692	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	22804890	24416692	146698375	95	9104										
SLC26A8	116369	broad.mit.edu	37	chr6	35928812	35928812	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgaagaaagcagaaactactGagataattagtccaatgtcc	8	7	0	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:35928812G>C	uc003olm.2	-	13	1637	c.1526C>G	c.(1525-1527)TCA>TGA	p.S509*	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Nonsense_Mutation_p.S91*|SLC26A8_uc003oln.2_Nonsense_Mutation_p.S509*|SLC26A8_uc003oll.2_Nonsense_Mutation_p.S404*	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	509	Helical; (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						AGAAACTACTGAGATAATTAG	0.413													0	0	0	0.038147	0	6	20										C	35928812	G	C	35928812	4	2	37	1	0	0	0	0	0	1	0	0	14523	1294	45	1	1418	1	SLC26A8	6	35928812	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	11512120	35928812	135186255	96	9105										
CRIP3	401262	broad.mit.edu	37	chr6	43273792	43273792	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgccatcccagtgtctgggaTggggctgcccacctttgggg	15	12	1	0	rs139840752	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:43273792T>C	uc010jyn.1	-	7	566	c.566A>G	c.(565-567)CAT>CGT	p.H189R	CRIP3_uc003ouu.1_Intron	NM_206922	NP_996805	Q6Q6R5	CRIP3_HUMAN	cysteine-rich protein 3	189						cytoplasm	zinc ion binding			skin(1)	1			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GTGTCTGGGATGGGGCTGCCC	0.557													0	0	0	0.139131	0	119	27										C	43273792	T	C	43273792	3	2	37	1	0	0	0	0	1	0	0	0	3876	1479	51	5		5	CRIP3	6	43273792	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	7344980	43273792	127841275	97	9106										
CLIC5	53405	broad.mit.edu	37	chr6	45922939	45922939	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaggatcatgaagaggcgctGagagaaaggacagttgccga	16	6	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:45922939G>A	uc003oxv.3	-	2	689	c.583C>T	c.(583-585)CAG>TAG	p.Q195*	CLIC5_uc003oxu.3_Nonsense_Mutation_p.Q36*|CLIC5_uc003oxx.2_Nonsense_Mutation_p.Q36*	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	195	Helical; Note=After insertion into the membrane; (Potential).				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						AAGAGGCGCTGAGAGAAAGGA	0.478													0	0	0	0.189662	0	15	11										A	45922939	G	A	45922939	4	1	37	1	0	0	0	0	0	1	0	0	3529	1299	45	1	669	1	CLIC5	6	45922939	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2649147	45922939	125192128	98	9107										
KCNQ5	56479	broad.mit.edu	37	chr6	73843246	73843246	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gacaggaggtccccaagcacCgacatcacagccgagggcag	13	14	1	0	rs139916334		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:73843246C>T	uc003pgk.2	+	10	1697	c.1350C>T	c.(1348-1350)ACC>ACT	p.T450T	KCNQ5_uc011dyh.1_Silent_p.T469T|KCNQ5_uc011dyi.1_Silent_p.T460T|KCNQ5_uc010kat.2_Silent_p.T441T|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Silent_p.T200T	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	450					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CCCCAAGCACCGACATCACAG	0.587													0	0	0	0.139131	0	47	56										T	73843246	C	T	73843246	2	4	37	1	0	0	0	0	0	0	0	1	8086	639	23	2		2	KCNQ5	6	73843246	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	27920307	73843246	97271821	99	9108										
MANEA	79694	broad.mit.edu	37	chr6	96054015	96054015	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggaacacgcaaaacactcggAaccgaatcaatgggaagtat	10	9	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:96054015A>G	uc003poo.1	+	5	1263	c.1123A>G	c.(1123-1125)AAC>GAC	p.N375D		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	375	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		AAACACTCGGAACCGAATCAA	0.413													0	0	0	0.139131	0	47	39										G	96054015	A	G	96054015	3	3	37	1	0	0	0	0	1	0	0	0	9221	246	9	5	1137	5	MANEA	6	96054015	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	22210769	96054015	75061052	100	9109										
NUS1	116150	broad.mit.edu	37	chr6	118028140	118028140	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aggactttttctctgcccttCgtcaatatgcagcctgtgaa	8	11	2	1	rs150953098		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:118028140C>T	uc003pxw.2	+	5	1061	c.844C>T	c.(844-846)CGT>TGT	p.R282C		NM_138459	NP_612468	Q96E22	NGBR_HUMAN	nuclear undecaprenyl pyrophosphate synthase 1	282	Cytoplasmic (Potential).				angiogenesis|cell differentiation	integral to membrane	receptor activity|transferase activity, transferring alkyl or aryl (other than methyl) groups			central_nervous_system(1)	1		all_cancers(87;0.0395)|all_epithelial(87;0.0301)		GBM - Glioblastoma multiforme(226;0.02)|OV - Ovarian serous cystadenocarcinoma(136;0.115)|all cancers(137;0.146)		CTCTGCCCTTCGTCAATATGC	0.433													0	0	0	0.108266	0	20	28										T	118028140	C	T	118028140	3	4	37	1	0	0	0	0	1	0	0	0	10777	884	31	1	862	1	NUS1	6	118028140	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	21974125	118028140	53086927	101	9110										
PTPRK	5796	broad.mit.edu	37	chr6	128312003	128312003	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtcaccataaacttcagtatCatcaggccaatatttatagc	5	10	4	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:128312003C>G	uc003qbk.2	-	21	3371	c.3004G>C	c.(3004-3006)GAT>CAT	p.D1002H	PTPRK_uc003qbj.2_Missense_Mutation_p.D1003H|PTPRK_uc010kfc.2_Missense_Mutation_p.D1009H|PTPRK_uc011ebu.1_Missense_Mutation_p.D1025H	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1002	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ACTTCAGTATCATCAGGCCAA	0.348													0	0	0	0.146539	0	12	47										G	128312003	C	G	128312003	3	3	37	1	0	0	0	0	1	0	0	0	12805	826	29	1	1355	1	PTPRK	6	128312003	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10283863	128312003	42803064	102	9111										
SYNE1	23345	broad.mit.edu	37	chr6	152462392	152462392	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aaagccaggaaggctctcctCttcctccttcagtttgtgct	8	13	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:152462392C>G	uc010kiw.2	-	139	25794	c.25192G>C	c.(25192-25194)GAG>CAG	p.E8398Q	SYNE1_uc010kiv.2_Missense_Mutation_p.E2922Q|SYNE1_uc003qos.3_Missense_Mutation_p.E2922Q|SYNE1_uc003qot.3_Missense_Mutation_p.E8350Q|SYNE1_uc003qou.3_Missense_Mutation_p.E8398Q|SYNE1_uc003qop.3_Missense_Mutation_p.E583Q|SYNE1_uc011eez.1_Missense_Mutation_p.E600Q|SYNE1_uc003qoq.3_Missense_Mutation_p.E600Q|SYNE1_uc003qor.3_Missense_Mutation_p.E1321Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8398	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGCTCTCCTCTTCCTCCTTC	0.488										HNSCC(10;0.0054)			0	0	0	0.139131	0	58	16										G	152462392	C	G	152462392	3	3	37	1	0	0	0	0	1	0	0	0	15442	922	32	1	1233	1	SYNE1	6	152462392	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	24150389	152462392	18652675	103	9112										
SYNE1	23345	broad.mit.edu	37	chr6	152690184	152690184	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aaagctcttgctggcagcttGtccttcccacagctgctgag	10	13	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:152690184G>C	uc010kiw.2	-	61	10332	c.9730C>G	c.(9730-9732)CAA>GAA	p.Q3244E	SYNE1_uc003qot.3_Missense_Mutation_p.Q3251E|SYNE1_uc003qou.3_Missense_Mutation_p.Q3244E|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.Q322E	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3244	Spectrin 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGCAGCTTGTCCTTCCCAC	0.498										HNSCC(10;0.0054)			0	0	0	0.058154	0	9	34										C	152690184	G	C	152690184	3	2	37	1	0	0	0	0	1	0	0	0	15442	1386	48	4	17080	4	SYNE1	6	152690184	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	227792	152690184	18424883	104	9113										
INTS1	26173	broad.mit.edu	37	chr7	1523488	1523488	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agacctggtcctgagactccGactgtgggaaaagaggtgga	15	8	0	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:1523488G>A	uc003skn.2	-	26	3532	c.3431C>T	c.(3430-3432)TCG>TTG	p.S1144L	INTS1_uc003skp.1_Missense_Mutation_p.S491L	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1144					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTGAGACTCCGACTGTGGGAA	0.647													0	0	0	0.189662	0	17	78										A	1523488	G	A	1523488	3	1	37	1	0	0	0	0	1	0	0	0	7775	1072	37	1	3233	1	INTS1	7	1523488	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		1523488	157615175	105	9114										
SDK1	221935	broad.mit.edu	37	chr7	3998602	3998602	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgagcccgagagtcggatttCagctgaagtagaagaaactg	13	7	1	5			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:3998602C>T	uc003smx.2	+	8	1329	c.1190C>T	c.(1189-1191)TCA>TTA	p.S397L		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	397	Ig-like C2-type 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGTCGGATTTCAGCTGAAGTA	0.468													0	0	0	0.069288	0	17	71										T	3998602	C	T	3998602	3	4	37	1	0	0	0	0	1	0	0	0	13968	838	29	1	1220	1	SDK1	7	3998602	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2475114	3998602	155140061	106	9115										
C7orf26	79034	broad.mit.edu	37	chr7	6629998	6629998	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	taccacctggacatctacttCagcagccagctgcagagcgc	9	15	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:6629998C>T	uc003sqo.1	+	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F	uc011jwy.1_5'Flank|C7orf26_uc003sqp.1_Silent_p.F28F|C7orf26_uc003sqq.1_5'UTR	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	28										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		ACATCTACTTCAGCAGCCAGC	0.622													0	0	0	0.175082	0	15	25										T	6629998	C	T	6629998	2	4	37	1	0	0	0	0	0	0	0	1	2381	825	29	1		1	C7orf26	7	6629998	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2631396	6629998	152508665	107	9116										
C1GALT1	56913	broad.mit.edu	37	chr7	7278084	7278084	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	actgaaaaccaaagaaggcaGagatcaactatactggaaaa	8	7	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:7278084G>C	uc010ktn.2	+	3	642	c.419G>C	c.(418-420)AGA>ACA	p.R140T	C1GALT1_uc003sra.2_Missense_Mutation_p.R140T|C1GALT1_uc010kto.1_Missense_Mutation_p.R140T	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	140	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AAAGAAGGCAGAGATCAACTA	0.373													0	0	0	0.080935	0	8	26										C	7278084	G	C	7278084	3	2	37	1	0	0	0	0	1	0	0	0	1952	942	33	1	425	1	C1GALT1	7	7278084	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	648086	7278084	151860579	108	9117										
DFNA5	1687	broad.mit.edu	37	chr7	24749946	24749946	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aagaccagggggtccaggtaGacagagtcaattctcttctt	11	9	3	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:24749946G>C	uc010kus.1	-	6	847	c.759C>G	c.(757-759)GTC>GTG	p.V253V	DFNA5_uc003swz.2_Silent_p.V89V|DFNA5_uc003sxa.1_Silent_p.V253V|DFNA5_uc010kut.1_Silent_p.V89V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	253					sensory perception of sound					ovary(1)	1						GGTCCAGGTAGACAGAGTCAA	0.473													0	0	0	0.146539	0	14	61										C	24749946	G	C	24749946	2	2	37	1	0	0	0	0	0	0	0	1	4454	929	33	1		1	DFNA5	7	24749946	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	17471862	24749946	134388717	109	9118										
URGCP	55665	broad.mit.edu	37	chr7	43916935	43916935	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cgcagcccaaacatggtgttGaggagtgtggacttgcccgt	14	10	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:43916935G>C	uc003tiw.2	-	6	2184	c.2127C>G	c.(2125-2127)CTC>CTG	p.L709L	URGCP_uc003tiu.2_Silent_p.L666L|URGCP_uc003tiv.2_Silent_p.L634L|URGCP_uc003tix.2_Silent_p.L700L|URGCP_uc003tiy.2_Silent_p.L666L|URGCP_uc003tiz.2_Silent_p.L666L|URGCP_uc011kbj.1_Silent_p.L666L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	709					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ACATGGTGTTGAGGAGTGTGG	0.627													0	0	0	0.203993	0	31	123										C	43916935	G	C	43916935	2	2	37	1	0	0	0	0	0	0	0	1	17023	1277	45	1		1	URGCP	7	43916935	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	19166989	43916935	115221728	110	9119										
C7orf57	136288	broad.mit.edu	37	chr7	48080989	48080989	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gccgtggatgccccaccagcGtcccagatcccaggtctcag	11	17	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:48080989G>A	uc003toh.3	+	3	326	c.114G>A	c.(112-114)GCG>GCA	p.A38A	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	38										ovary(1)	1						CCCCACCAGCGTCCCAGATCC	0.537													0	0	0	0.139131	0	36	49										A	48080989	G	A	48080989	2	1	37	1	0	0	0	0	0	0	0	1	2404	1132	40	2		2	C7orf57	7	48080989	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	4164054	48080989	111057674	111	9120										
C7orf42	55069	broad.mit.edu	37	chr7	66418353	66418353	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatcctgaattttgtcccgaGaaggtgagcggtggatgggg	16	6	0	3	rs149604295		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:66418353G>A	uc003tvk.2	+	6	1185	c.921G>A	c.(919-921)GAG>GAA	p.E307E	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Silent_p.E307E	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	307						integral to membrane				ovary(1)	1						TTTGTCCCGAGAAGGTGAGCG	0.453													0	0	0	0.124865	0	35	180										A	66418353	G	A	66418353	2	1	37	1	0	0	0	0	0	0	0	1	2392	933	33	1		1	C7orf42	7	66418353	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	18337364	66418353	92720310	112	9121										
HIP1	3092	broad.mit.edu	37	chr7	75190679	75190679	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccttcaatccactgatctctCtgtatagtcgctcaattaag	5	12	4	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:75190679C>G	uc003uds.1	-	13	1186	c.1145G>C	c.(1144-1146)AGA>ACA	p.R382T	HIP1_uc011kfz.1_Missense_Mutation_p.R259T	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	382	Potential.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						ACTGATCTCTCTGTATAGTCG	0.443			T	PDGFRB	CMML								0	0	0	0.139131	0	46	85										G	75190679	C	G	75190679	3	3	37	1	0	0	0	0	1	0	0	0	7114	913	32	1	2044	1	HIP1	7	75190679	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	8772326	75190679	83947984	113	9122										
DTX2	113878	broad.mit.edu	37	chr7	76112191	76112191	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagaactggccccgtgtcagGccgctaccgccactccatga	10	17	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:76112191G>T	uc003uff.3	+	5	1191	c.635G>T	c.(634-636)GGC>GTC	p.G212V	DTX2_uc011kgk.1_Missense_Mutation_p.G121V|DTX2_uc003ufg.3_Missense_Mutation_p.G212V|DTX2_uc003ufh.3_Missense_Mutation_p.G212V|DTX2_uc003ufj.3_Missense_Mutation_p.G212V	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	212					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCCGTGTCAGGCCGCTACCGC	0.662													1	0	1.00246e-47	0.139131	1.07454e-47	45	444										T	76112191	G	T	76112191	3	4	37	1	0	0	0	0	1	0	0	0	4794	1203	42	4	641	4	DTX2	7	76112191	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	921512	76112191	83026472	114	9123										
FZD1	8321	broad.mit.edu	37	chr7	90895017	90895017	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcgtcggagcgaggcaagttCtcctgcccgcgcgccctcaa	13	16	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:90895017C>T	uc003ula.2	+	1	1235	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	274	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GAGGCAAGTTCTCCTGCCCGC	0.692													0	0	0	0.080935	0	11	8										T	90895017	C	T	90895017	2	4	37	1	0	0	0	0	0	0	0	1	6128	912	32	1		1	FZD1	7	90895017	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	14782826	90895017	68243646	115	9124										
COPS6	10980	broad.mit.edu	37	chr7	99686983	99686983	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctccatccccttgtcattctCaacatctcagaccactggat	4	16	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:99686983C>G	uc003usu.2	+	2	178	c.147C>G	c.(145-147)CTC>CTG	p.L49L	COPS6_uc011kjf.1_Silent_p.L49L	NM_006833	NP_006824	Q7L5N1	CSN6_HUMAN	COP9 signalosome subunit 6	49	MPN.				cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTGTCATTCTCAACATCTCAG	0.592													0	0	0	0.139131	0	134	175										G	99686983	C	G	99686983	2	3	37	1	0	0	0	0	0	0	0	1	3737	813	29	1		1	COPS6	7	99686983	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	8791966	99686983	59451680	116	9125										
SRRT	51593	broad.mit.edu	37	chr7	100483362	100483362	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctttatgcgggtggcgctctCagagccccagccagagagga	14	12	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:100483362C>G	uc003uwy.2	+	12	1626	c.1358C>G	c.(1357-1359)TCA>TGA	p.S453*	SRRT_uc010lhl.1_Nonsense_Mutation_p.S452*|SRRT_uc003uxa.2_Nonsense_Mutation_p.S452*|SRRT_uc003uwz.2_Nonsense_Mutation_p.S453*	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	453					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GTGGCGCTCTCAGAGCCCCAG	0.537													0	0	0	0.02938	0	5	21										G	100483362	C	G	100483362	4	3	37	1	0	0	0	0	0	1	0	0	15171	838	29	1	1396	1	SRRT	7	100483362	Nonsense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	796379	100483362	58655301	117	9126										
LRRC4	64101	broad.mit.edu	37	chr7	127670203	127670203	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcacccggttgaaggcgtaaGaggggatgctttcgatgggg	18	7	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:127670203G>C	uc003vmk.2	-	2	628	c.491C>G	c.(490-492)TCT>TGT	p.S164C	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	164	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GAAGGCGTAAGAGGGGATGCT	0.572													0	0	0	0.214465	0	30	135										C	127670203	G	C	127670203	3	2	37	1	0	0	0	0	1	0	0	0	8997	942	33	1	1474	1	LRRC4	7	127670203	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	27186841	127670203	31468460	118	9127										
CLCN1	1180	broad.mit.edu	37	chr7	143039166	143039166	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggcccagagcctgcagccctCtctctatgacagcatcatcc	8	17	3	2	rs143825889		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:143039166C>G	uc003wcr.1	+	15	1814	c.1727C>G	c.(1726-1728)TCT>TGT	p.S576C	CLCN1_uc011ktc.1_Missense_Mutation_p.S188C	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	576	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CTGCAGCCCTCTCTCTATGAC	0.527													0	0	0	0.09836	0	36	47										G	143039166	C	G	143039166	3	3	37	1	0	0	0	0	1	0	0	0	3462	913	32	1	1785	1	CLCN1	7	143039166	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	15368963	143039166	16099497	119	9128										
OR2F1	26211	broad.mit.edu	37	chr7	143657918	143657918	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gccattttaacaccaatgctGaaccccatgatttacagcct	5	13	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:143657918G>A	uc003wds.1	+	1	899	c.855G>A	c.(853-855)CTG>CTA	p.L285L		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					CACCAATGCTGAACCCCATGA	0.453													0	0	0	0.153744	0	26	46										A	143657918	G	A	143657918	2	1	37	1	0	0	0	0	0	0	0	1	10996	1277	45	1		1	OR2F1	7	143657918	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	618752	143657918	15480745	120	9129										
ZNF425	155054	broad.mit.edu	37	chr7	148800826	148800826	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctccccactgtgaaggcacaGatgggccttcaggcttctct	10	14	2	2	rs142180575		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:148800826G>A	uc003wfj.2	-	4	2210	c.2137C>T	c.(2137-2139)CTG>TTG	p.L713L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	713	C2H2-type 18.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGAAGGCACAGATGGGCCTTC	0.552													0	0	0	0.062417	0	19	27										A	148800826	G	A	148800826	2	1	37	1	0	0	0	0	0	0	0	1	17896	933	33	1		1	ZNF425	7	148800826	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	5142908	148800826	10337837	121	9130										
ZNF425	155054	broad.mit.edu	37	chr7	148801778	148801778	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tccagcttaatcttgtagatGaatttcctgccacattcacc	5	12	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:148801778G>A	uc003wfj.2	-	4	1258	c.1185C>T	c.(1183-1185)TTC>TTT	p.F395F		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	395	C2H2-type 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTTGTAGATGAATTTCCTGC	0.532													0	0	0	0.139131	0	55	92										A	148801778	G	A	148801778	2	1	37	1	0	0	0	0	0	0	0	1	17896	1281	45	1		1	ZNF425	7	148801778	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	952	148801778	10336885	122	9131										
CTSB	1508	broad.mit.edu	37	chr8	11708405	11708405	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccacaggagccctggtctctGatctctttgatggtgggaca	12	11	2	2	rs144771892		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:11708405G>C	uc003wum.2	-	6	621	c.297C>G	c.(295-297)ATC>ATG	p.I99M	CTSB_uc003wul.2_5'Flank|CTSB_uc011kxl.1_Intron|CTSB_uc003wun.2_Missense_Mutation_p.I99M|CTSB_uc003wuo.2_Missense_Mutation_p.I99M|CTSB_uc003wup.2_Missense_Mutation_p.I99M|CTSB_uc003wuq.2_Missense_Mutation_p.I99M|CTSB_uc010lsc.2_Nonsense_Mutation_p.S15*|CTSB_uc003wur.2_Missense_Mutation_p.I99M|CTSB_uc003wus.1_Missense_Mutation_p.I99M|CTSB_uc003wut.1_Missense_Mutation_p.I99M|CTSB_uc003wuu.2_5'Flank	NM_147780	NP_680090	P07858	CATB_HUMAN	cathepsin B preproprotein	99					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity				0	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CCTGGTCTCTGATCTCTTTGA	0.572													0	0	0	0.132662	0	10	14										C	11708405	G	C	11708405	3	2	37	1	0	0	0	0	1	0	0	0	4030	1280	45	1	750	1	CTSB	8	11708405	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		11708405	134655617	123	9132										
TNFRSF10A	8797	broad.mit.edu	37	chr8	23082521	23082521	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctcgctgcgctcccgggattCggagtcactgccaggaacgc	13	15	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:23082521C>G	uc003xda.2	-	1	119	c.54G>C	c.(52-54)CCG>CCC	p.P18P	uc003xdb.1_5'Flank	NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	18					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TCCCGGGATTCGGAGTCACTG	0.632													0	0	0	0.062417	0	14	16										G	23082521	C	G	23082521	2	3	37	1	0	0	0	0	0	0	0	1	16277	871	31	1		1	TNFRSF10A	8	23082521	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	11374116	23082521	123281501	124	9133										
ANK1	286	broad.mit.edu	37	chr8	41583422	41583422	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaggtgcgcgacgacgttctCatggccctgctgcagggcta	15	12	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:41583422C>T	uc003xok.2	-	6	553	c.469G>A	c.(469-471)GAG>AAG	p.E157K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.E157K|ANK1_uc003xoj.2_Missense_Mutation_p.E157K|ANK1_uc003xol.2_Missense_Mutation_p.E157K|ANK1_uc003xom.2_Missense_Mutation_p.E190K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	157	ANK 4.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACGACGTTCTCATGGCCCTGC	0.662													0	0	0	0.183431	0	26	18										T	41583422	C	T	41583422	3	4	37	1	0	0	0	0	1	0	0	0	620	835	29	1	5678	1	ANK1	8	41583422	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	18500901	41583422	104780600	125	9134										
PI15	51050	broad.mit.edu	37	chr8	75737599	75737599	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cgccaaccaataatttcactGatattgaagcagctctgaaa	6	10	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:75737599G>A	uc003yal.2	+	2	294	c.115G>A	c.(115-117)GAT>AAT	p.D39N	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.D39N	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	39						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TAATTTCACTGATATTGAAGC	0.488													0	0	0	0.139131	0	50	50										A	75737599	G	A	75737599	3	1	37	1	0	0	0	0	1	0	0	0	11868	1290	45	1	117	1	PI15	8	75737599	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	34154177	75737599	70626423	126	9135										
STMN2	11075	broad.mit.edu	37	chr8	80549051	80549051	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tttcagcctacaaggaaaaaAtgaaggagctgtccatgctg	10	8	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:80549051A>G	uc003ybj.2	+	2	85	c.34A>G	c.(34-36)ATG>GTG	p.M12V	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Missense_Mutation_p.M12V	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	12	Membrane attachment (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CAAGGAAAAAATGAAGGAGCT	0.358													0	0	0	0.132662	0	11	33										G	80549051	A	G	80549051	3	3	37	1	0	0	0	0	1	0	0	0	15308	101	4	5	40	5	STMN2	8	80549051	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	4811452	80549051	65814971	127	9136										
KCNV1	27012	broad.mit.edu	37	chr8	110984713	110984713	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aggaagcggaggacaaactcCccggtgaaccagctaatgca	12	11	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:110984713C>T	uc003ynr.3	-	2	1107	c.765G>A	c.(763-765)GGG>GGA	p.G255G	KCNV1_uc010mcw.2_Silent_p.G255G	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	255	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GGACAAACTCCCCGGTGAACC	0.522													0	0	0	0.160694	0	15	67										T	110984713	C	T	110984713	2	4	37	1	0	0	0	0	0	0	0	1	8094	610	22	2		2	KCNV1	8	110984713	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	30435662	110984713	35379309	128	9137										
SNTB1	6641	broad.mit.edu	37	chr8	121644785	121644785	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatcactcgggtcagcaggtCattaacgttggaatggatgg	13	7	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:121644785C>A	uc010mdg.2	-	3	1121	c.895G>T	c.(895-897)GAC>TAC	p.D299Y	SNTB1_uc003ype.2_Missense_Mutation_p.D299Y	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	299					muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GTCAGCAGGTCATTAACGTTG	0.537													1	0	3.73988e-18	0.116897	3.96984e-18	24	67										A	121644785	C	A	121644785	3	1	37	1	0	0	0	0	1	0	0	0	14872	826	29	3	741	3	SNTB1	8	121644785	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10660072	121644785	24719237	129	9138										
C8orf76	84933	broad.mit.edu	37	chr8	124238796	124238796	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaaccctttcattttatcttCaatttcctgctgagtcctta	4	11	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:124238796C>T	uc003yqc.1	-	5	923	c.892G>A	c.(892-894)GAA>AAA	p.E298K	C8orf76_uc003yqd.2_Missense_Mutation_p.E266K	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	298							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTTATCTTCAATTTCCTGC	0.418													0	0	0	0.021553	0	4	26										T	124238796	C	T	124238796	3	4	37	1	0	0	0	0	1	0	0	0	2437	835	29	1	258	1	C8orf76	8	124238796	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2594011	124238796	22125226	130	9139										
FLJ43860	389690	broad.mit.edu	37	chr8	142490016	142490016	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcctgggtcctcacctccctCtgcttgggccactggtggga	13	15	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:142490016C>G	uc003ywi.2	-	8	1050	c.969G>C	c.(967-969)CAG>CAC	p.Q323H	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	323							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCACCTCCCTCTGCTTGGGCC	0.592													0	0	0	0.11911	0	12	48										G	142490016	C	G	142490016	3	3	37	1	0	0	0	0	1	0	0	0	5930	912	32	1	3079	1	FLJ43860	8	142490016	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	18251220	142490016	3874006	131	9140										
GRINA	2907	broad.mit.edu	37	chr8	145066426	145066426	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	actgcagtcggtcctgaccgCcagcctgtcgtacatggtgg	13	13	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:145066426C>T	uc003zan.1	+	5	873	c.707C>T	c.(706-708)GCC>GTC	p.A236V	GRINA_uc003zao.1_Missense_Mutation_p.A236V|GRINA_uc003zap.1_Missense_Mutation_p.A236V	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	236	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCTGACCGCCAGCCTGTCG	0.627													0	0	0	0.055883	0	16	112										T	145066426	C	T	145066426	3	4	37	1	0	0	0	0	1	0	0	0	6785	739	26	2	721	2	GRINA	8	145066426	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2576410	145066426	1297596	132	9141										
HSF1	3297	broad.mit.edu	37	chr8	145535421	145535421	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tacagcagctccagcctctaCgcccctgatgctgtggccag	10	16	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:145535421C>T	uc003zbt.3	+	8	929	c.759C>T	c.(757-759)TAC>TAT	p.Y253Y	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	253	Regulatory domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCAGCCTCTACGCCCCTGATG	0.672													0	0	0	0.193644	0	26	83										T	145535421	C	T	145535421	2	4	37	1	0	0	0	0	0	0	0	1	7395	547	19	2		2	HSF1	8	145535421	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	468995	145535421	828601	133	9142										
DOCK8	81704	broad.mit.edu	37	chr9	339064	339064	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tttagctgactacaaaagatCatcatccttacagagacgag	7	9	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:339064C>T	uc003zgf.2	+	13	1593	c.1481C>T	c.(1480-1482)TCA>TTA	p.S494L	DOCK8_uc011lls.1_Missense_Mutation_p.S494L|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Missense_Mutation_p.S426L|DOCK8_uc003zgg.2_Missense_Mutation_p.S426L|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	494	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TACAAAAGATCATCATCCTTA	0.398													0	0	0	0.150653	0	3	11										T	339064	C	T	339064	3	4	37	1	0	0	0	0	1	0	0	0	4693	838	29	1	1531	1	DOCK8	9	339064	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		339064	140874367	134	9143										
IFNA4	3441	broad.mit.edu	37	chr9	21187385	21187385	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgtccttcaggcaggagaaaTgagagattcttcccatttgt	10	8	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:21187385T>G	uc003zon.2	-	1	214	c.146A>C	c.(145-147)CAT>CCT	p.H49P		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	49					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GCAGGAGAAATGAGAGATTCT	0.517													0	0	0	0.086207	0	30	55										G	21187385	T	G	21187385	3	3	37	1	0	0	0	0	1	0	0	0	7539	1464	51	5	427	5	IFNA4	9	21187385	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	20848321	21187385	120026046	135	9144										
OR13F1	138805	broad.mit.edu	37	chr9	107267429	107267429	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tctatagtctacggaacaaaGaggtgaaagtggccttgaaa	11	6	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:107267429G>C	uc011lvm.1	+	1	886	c.886G>C	c.(886-888)GAG>CAG	p.E296Q		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						ACGGAACAAAGAGGTGAAAGT	0.373													0	0	0	0.076483	0	20	4										C	107267429	G	C	107267429	3	2	37	1	0	0	0	0	1	0	0	0	10941	943	33	1	888	1	OR13F1	9	107267429	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	86080044	107267429	33946002	136	9145										
NUP188	23511	broad.mit.edu	37	chr9	131745215	131745215	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgccagcgagtcaaacccatCattgatctcgtccataaggt	8	12	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:131745215C>T	uc004bws.1	+	17	1726	c.1704C>T	c.(1702-1704)ATC>ATT	p.I568I	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	568					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TCAAACCCATCATTGATCTCG	0.502													0	0	0	0.139131	0	40	52										T	131745215	C	T	131745215	2	4	37	1	0	0	0	0	0	0	0	1	10758	816	29	1		1	NUP188	9	131745215	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	24477786	131745215	9468216	137	9146										
GPR107	57720	broad.mit.edu	37	chr9	132889830	132889830	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctcgctgttccattccagtgGaagtggctctaccaggtacg	11	12	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:132889830G>A	uc004bze.2	+	18	1796	c.1569G>A	c.(1567-1569)TGG>TGA	p.W523*	GPR107_uc004bzb.2_Nonsense_Mutation_p.W286*|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Nonsense_Mutation_p.W494*|GPR107_uc004bzd.2_Nonsense_Mutation_p.W475*|GPR107_uc004bzg.1_5'Flank	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	523						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CATTCCAGTGGAAGTGGCTCT	0.418													0	0	0	0.153744	0	25	12										A	132889830	G	A	132889830	4	1	37	1	0	0	0	0	0	1	0	0	6623	1183	41	1	1639	1	GPR107	9	132889830	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1144615	132889830	8323601	138	9147										
TUBB8	347688	broad.mit.edu	37	chr10	93872	93872	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgggtactcctcccggatctTactgagcagaagggtaccca	11	12	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:93872T>G	uc001ifi.2	-	4	460	c.460A>C	c.(460-462)AAG>CAG	p.K154Q	TUBB8_uc009xhe.2_Missense_Mutation_p.K117Q|TUBB8_uc010pzs.1_Missense_Mutation_p.K82Q	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	154					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TCCCGGATCTTACTGAGCAGA	0.602													0	0	0	0.175082	0	15	250										G	93872	T	G	93872	3	3	37	1	0	0	0	0	1	0	0	0	16758	1763	61	5	878	5	TUBB8	10	93872	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08		93872	135440875	139	9148										
PFKFB3	5209	broad.mit.edu	37	chr10	6261552	6261552	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaagttaaaatctccagcccGgattacaaagactgcaactc	7	11	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:6261552G>A	uc001ije.2	+	7	903	c.519G>A	c.(517-519)CCG>CCA	p.P173P	PFKFB3_uc001ijd.2_Silent_p.P153P|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Silent_p.P187P|PFKFB3_uc001ijf.2_Silent_p.P173P	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	173	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding	p.P173P(1)		ovary(2)|central_nervous_system(1)	3						TCTCCAGCCCGGATTACAAAG	0.507													0	0	0	0.184627	0	5	110										A	6261552	G	A	6261552	2	1	37	1	0	0	0	0	0	0	0	1	11762	1103	39	2		2	PFKFB3	10	6261552	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	6167680	6261552	129273195	140	9149										
CUBN	8029	broad.mit.edu	37	chr10	17153011	17153011	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gccgttatttatctcacattCattgatatcttcgcaaatat	4	9	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:17153011C>T	uc001ioo.2	-	9	974	c.922G>A	c.(922-924)GAA>AAA	p.E308K		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	308	EGF-like 4; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATCTCACATTCATTGATATCT	0.413													0	0	0	0.146539	0	14	70										T	17153011	C	T	17153011	3	4	37	1	0	0	0	0	1	0	0	0	4051	835	29	1	10185	1	CUBN	10	17153011	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10891459	17153011	118381736	141	9150										
NSUN6	221078	broad.mit.edu	37	chr10	18905124	18905124	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tatacttacattgtgatgctGacacaattcctggggcatag	9	8	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:18905124G>A	uc010qcp.1	-	4	828	c.410C>T	c.(409-411)TCA>TTA	p.S137L		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	137	PUA.						methyltransferase activity|RNA binding			ovary(2)	2						TTGTGATGCTGACACAATTCC	0.343													0	0	0	0.139131	0	39	10										A	18905124	G	A	18905124	3	1	37	1	0	0	0	0	1	0	0	0	10682	1294	45	1	1031	1	NSUN6	10	18905124	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1752113	18905124	116629623	142	9151										
NEBL	10529	broad.mit.edu	37	chr10	21102872	21102872	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tctggttggaccctaccattGaaatatgattttgtgcttct	8	8	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:21102872G>C	uc001iqi.2	-	23	2739	c.2342C>G	c.(2341-2343)TCA>TGA	p.S781*	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	781	Nebulin 22.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCCTACCATTGAAATATGATT	0.383													0	0	0	0.105934	0	9	29										C	21102872	G	C	21102872	4	2	37	1	0	0	0	0	0	1	0	0	10303	1294	45	1	726	1	NEBL	10	21102872	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2197748	21102872	114431875	143	9152										
RASGEF1A	221002	broad.mit.edu	37	chr10	43696157	43696157	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgggccagcaccagggggtcGcagcacacgcccaggatgtc	15	14	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:43696157G>A	uc001jap.1	-	5	720	c.639C>T	c.(637-639)TGC>TGT	p.C213C	RASGEF1A_uc001jao.1_Silent_p.C221C	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	213					cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						CCAGGGGGTCGCAGCACACGC	0.642													0	0	0	0.021553	0	5	54										A	43696157	G	A	43696157	2	1	37	1	0	0	0	0	0	0	0	1	13069	1079	38	2		2	RASGEF1A	10	43696157	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	22593285	43696157	91838590	144	9153										
ZNF32	7580	broad.mit.edu	37	chr10	44140096	44140096	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	actcctggcactcatagaccCtttgtctcactccaggtgaa	7	14	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:44140096C>G	uc001jbb.2	-	3	413	c.224G>C	c.(223-225)AGG>ACG	p.R75T	uc001jba.2_Intron|ZNF32_uc001jbc.2_Missense_Mutation_p.R75T	NM_001005368	NP_001005368	P17041	ZNF32_HUMAN	zinc finger protein 32	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		CTCATAGACCCTTTGTCTCAC	0.448													0	0	0	0.139131	0	37	23										G	44140096	C	G	44140096	3	3	37	1	0	0	0	0	1	0	0	0	17835	681	24	4	601	4	ZNF32	10	44140096	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	443939	44140096	91394651	145	9154										
PAPSS2	9060	broad.mit.edu	37	chr10	89504908	89504908	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttgagcatggcccctggcctCacctctgtggaaatcattcc	9	14	3	1	rs7918595		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:89504908C>T	uc001kex.2	+	11	1889	c.1626C>T	c.(1624-1626)CTC>CTT	p.L542L	PAPSS2_uc001kew.2_Silent_p.L547L	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	542	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CCCCTGGCCTCACCTCTGTGG	0.512													0	0	0	0.189662	0	16	4										T	89504908	C	T	89504908	2	4	37	1	0	0	0	0	0	0	0	1	11435	813	29	1		1	PAPSS2	10	89504908	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	45364812	89504908	46029839	146	9155										
ACTA2	59	broad.mit.edu	37	chr10	90695108	90695108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccagacagagtatttgcgctCcggaggggcaatgatctgtc	13	10	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:90695108C>T	uc001kfp.2	-	9	1122	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.E291K|ACTA2_uc001kfq.2_Missense_Mutation_p.E336K|uc001kfo.1_RNA	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	336					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TATTTGCGCTCCGGAGGGGCA	0.507											OREG0020356	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	56	16										T	90695108	C	T	90695108	3	4	37	1	0	0	0	0	1	0	0	0	192	864	30	1	131	1	ACTA2	10	90695108	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1190200	90695108	44839639	147	9156										
CUTC	51076	broad.mit.edu	37	chr10	101503808	101503808	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttatagctatttgccgccctCtgccagtcactttccaccga	6	15	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:101503808C>G	uc001kqd.3	+	5	566	c.418C>G	c.(418-420)CTG>GTG	p.L140V	CUTC_uc010qpk.1_Missense_Mutation_p.L140V|CUTC_uc001kqe.3_RNA	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	140					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		TTGCCGCCCTCTGCCAGTCAC	0.348													0	0	0	0.214465	0	23	9										G	101503808	C	G	101503808	3	3	37	1	0	0	0	0	1	0	0	0	4063	912	32	1	436	1	CUTC	10	101503808	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10808700	101503808	34030939	148	9157										
GFRA1	2674	broad.mit.edu	37	chr10	118030457	118030457	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctccatggcgctgcggcactCatccttggcctccaggccgg	12	17	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:118030457C>G	uc001lcj.2	-	3	909	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	GFRA1_uc001lci.2_Missense_Mutation_p.E71Q|GFRA1_uc009xyr.2_Missense_Mutation_p.E71Q	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	71	1.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTGCGGCACTCATCCTTGGCC	0.607													0	0	0	0.086207	0	33	49										G	118030457	C	G	118030457	3	3	37	1	0	0	0	0	1	0	0	0	6347	835	29	1	1222	1	GFRA1	10	118030457	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	16526649	118030457	17504290	149	9158										
ANO9	338440	broad.mit.edu	37	chr11	418436	418436	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atgggcaggcattgggggccGagagcctgcccccaccccac	14	16	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:418436G>A	uc001lpi.2	-	23	2369	c.2284C>T	c.(2284-2286)CGG>TGG	p.R762W	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Missense_Mutation_p.R455W|ANO9_uc010qvv.1_Missense_Mutation_p.R618W	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	762	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						ATTGGGGGCCGAGAGCCTGCC	0.627													0	0	0	0.132662	0	14	28										A	418436	G	A	418436	3	1	37	1	0	0	0	0	1	0	0	0	704	1057	37	1	68	1	ANO9	11	418436	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		418436	134588080	150	9159										
TSPAN4	7106	broad.mit.edu	37	chr11	862710	862710	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cttcgtgggctgcctgggtgCcatcaaggagaacaagtgcc	14	11	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:862710C>T	uc001lsd.1	+	4	433	c.224C>T	c.(223-225)GCC>GTC	p.A75V	TSPAN4_uc001lse.1_Missense_Mutation_p.A11V|TSPAN4_uc001lsf.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsg.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsh.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsi.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsj.1_Missense_Mutation_p.A75V	NM_003271	NP_003262	O14817	TSN4_HUMAN	tetraspanin 4 isoform a	75	Helical; (Potential).				protein complex assembly	integral to plasma membrane				breast(1)	1		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCCTGGGTGCCATCAAGGAG	0.667													0	0	0	0.080935	0	8	22										T	862710	C	T	862710	3	4	37	1	0	0	0	0	1	0	0	0	16646	739	26	2	230	2	TSPAN4	11	862710	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	444274	862710	134143806	151	9160										
OR52W1	120787	broad.mit.edu	37	chr11	6220474	6220474	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atggcagaaactctacaactCaattccaccttcctacaccc	3	16	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:6220474C>G	uc010qzz.1	+	1	21	c.21C>G	c.(19-21)CTC>CTG	p.L7L		NM_001005178	NP_001005178	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTACAACTCAATTCCACCT	0.517													0	0	0	0.214465	0	34	43										G	6220474	C	G	6220474	2	3	37	1	0	0	0	0	0	0	0	1	11132	813	29	1		1	OR52W1	11	6220474	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	5357764	6220474	128786042	152	9161										
TSG101	7251	broad.mit.edu	37	chr11	18503374	18503374	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagagcagaactgagttcttCatccttctttttcaaaagtt	6	9	4	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:18503374C>A	uc001mor.2	-	9	1012	c.886G>T	c.(886-888)GAA>TAA	p.E296*		NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	296	Potential.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0						CTGAGTTCTTCATCCTTCTTT	0.358													1	0	2.17888e-05	0.058154	2.21948e-05	10	13										A	18503374	C	A	18503374	4	1	37	1	0	0	0	0	0	1	0	0	16613	835	29	3	294	3	TSG101	11	18503374	Nonsense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	12282900	18503374	116503142	153	9162										
API5	8539	broad.mit.edu	37	chr11	43333683	43333683	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggcttgtcgctcaccatgccGacagtagaggagctttaccg	12	12	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:43333683G>A	uc010rfh.1	+	1	179	c.6G>A	c.(4-6)CCG>CCA	p.P2P	API5_uc010rfg.1_5'UTR|API5_uc001mxf.2_Silent_p.P2P|API5_uc010rfi.1_Silent_p.P2P	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	2		Not acetylated.			anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCACCATGCCGACAGTAGAGG	0.647											OREG0020900	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	42	35										A	43333683	G	A	43333683	2	1	37	1	0	0	0	0	0	0	0	1	773	1045	37	1		1	API5	11	43333683	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	24830309	43333683	91672833	154	9163										
TCN1	6947	broad.mit.edu	37	chr11	59630175	59630175	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagtataatcaaggcaagctCtcccgagcttacatctgaca	7	12	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:59630175C>G	uc001noj.2	-	3	378	c.280G>C	c.(280-282)GAG>CAG	p.E94Q		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	94					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGGCAAGCTCTCCCGAGCTT	0.383													0	0	0	0.055883	0	15	26										G	59630175	C	G	59630175	3	3	37	1	0	0	0	0	1	0	0	0	15703	922	32	1	1049	1	TCN1	11	59630175	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	16296492	59630175	75376341	155	9164										
PPFIA1	8500	broad.mit.edu	37	chr11	70194407	70194407	+	Frame_Shift_Del	DEL	C	C	-													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttagatcaatgagctccattCccccctaccctgcttcctcg							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:70194407delC	uc001opo.2	+	16	2242	c.2044delC	c.(2044-2046)CCCfs	p.P682fs	PPFIA1_uc001opn.1_Frame_Shift_Del_p.P682fs|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	682					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GAGCTCCATTCCCCCCTACCC	0.557																		8	2895	---	---								-	70194407	C	-	70194407	7	5	37	1	0	1	0	1	0	0	0	0	12309	855	30	0	2102	0	PPFIA1	11	70194407	Frame_Shift_Del	DEL	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10564232	70194407	64812109	156	9165										
KRTAP5-11	440051	broad.mit.edu	37	chr11	71293573	71293573	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agcagggtttggagcagctgGactggcagcagaatgaccca	15	9	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:71293573G>C	uc001oqu.2	-	1	349	c.311C>G	c.(310-312)TCC>TGC	p.S104C		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	104	6 X 4 AA repeats of C-C-X-P.					keratin filament					0						ggagcagctggactggcagca	0.179													0	0	0	0.139131	0	65	149										C	71293573	G	C	71293573	3	2	37	1	0	0	0	0	1	0	0	0	8560	1174	41	1	163	1	KRTAP5-11	11	71293573	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1099166	71293573	63712943	157	9166										
NAALAD2	10003	broad.mit.edu	37	chr11	89914805	89914805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aagactccttattttctgctGtgaaaaacttctcagaggct	7	9	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:89914805G>A	uc001pdf.3	+	17	1985	c.1876G>A	c.(1876-1878)GTG>ATG	p.V626M	NAALAD2_uc009yvx.2_Missense_Mutation_p.V593M|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	626	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ATTTTCTGCTGTGAAAAACTT	0.318													0	0	0	0.184627	0	3	10										A	89914805	G	A	89914805	3	1	37	1	0	0	0	0	1	0	0	0	10128	1377	48	2	1942	2	NAALAD2	11	89914805	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	18621232	89914805	45091711	158	9167										
NAALAD2	10003	broad.mit.edu	37	chr11	89924900	89924900	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caagcagcagcaggaactctGaaagaagtattatagaaggt	11	6	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:89924900G>A	uc001pdf.3	+	19	2317	c.2208G>A	c.(2206-2208)CTG>CTA	p.L736L	NAALAD2_uc009yvx.2_Silent_p.L703L|NAALAD2_uc009yvy.2_3'UTR	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	736	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CAGGAACTCTGAAAGAAGTAT	0.368													0	0	0	0.038147	0	6	17										A	89924900	G	A	89924900	2	1	37	1	0	0	0	0	0	0	0	1	10128	1277	45	1		1	NAALAD2	11	89924900	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	10095	89924900	45081616	159	9168										
IL10RA	3587	broad.mit.edu	37	chr11	117869673	117869673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acagaacgctgggaaacaggGagccccctgtgctgggggac	16	11	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:117869673G>A	uc001prv.2	+	7	1131	c.1054G>A	c.(1054-1056)GAG>AAG	p.E352K	IL10RA_uc010rxl.1_Missense_Mutation_p.E332K|IL10RA_uc010rxm.1_Missense_Mutation_p.E332K|IL10RA_uc010rxn.1_Missense_Mutation_p.E203K|IL10RA_uc001prw.2_Missense_Mutation_p.E203K	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	352	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GGGAAACAGGGAGCCCCCTGT	0.647													0	0	0	0.108266	0	19	29										A	117869673	G	A	117869673	3	1	37	1	0	0	0	0	1	0	0	0	7620	1175	41	1	1080	1	IL10RA	11	117869673	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	27944773	117869673	17136843	160	9169										
GNB3	2784	broad.mit.edu	37	chr12	6954874	6954874	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	catcatctgcggcatcacgtCcgtggccttctccctcagtg	9	16	5	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:6954874C>G	uc001qrd.2	+	10	1229	c.824C>G	c.(823-825)TCC>TGC	p.S275C	GNB3_uc001qrc.2_Missense_Mutation_p.S231C|GNB3_uc009zfe.2_Missense_Mutation_p.S274C|CDCA3_uc001qre.2_3'UTR|uc001qrf.1_RNA	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	275	WD 6.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GGCATCACGTCCGTGGCCTTC	0.597													0	0	0	0.139131	0	149	237										G	6954874	C	G	6954874	3	3	37	1	0	0	0	0	1	0	0	0	6519	855	30	1	854	1	GNB3	12	6954874	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		6954874	126897021	161	9170										
CDCA3	83461	broad.mit.edu	37	chr12	6959647	6959647	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttacctccactgctggtcttCataggtgtccgtgcaatacc	8	13	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:6959647C>T	uc001qrg.2	-	3	362	c.234G>A	c.(232-234)ATG>ATA	p.M78I	CDCA3_uc001qre.2_Missense_Mutation_p.M78I|uc001qrf.1_5'Flank|USP5_uc001qri.3_5'Flank|USP5_uc001qrh.3_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	78					cell division|mitosis	cytosol					0						TGCTGGTCTTCATAGGTGTCC	0.542													0	0	0	0.139131	0	96	117										T	6959647	C	T	6959647	3	4	37	1	0	0	0	0	1	0	0	0	3087	826	29	1	588	1	CDCA3	12	6959647	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4773	6959647	126892248	162	9171										
ATF7IP	55729	broad.mit.edu	37	chr12	14633975	14633975	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	taacacatcgtccagtaactCaggtgaccacaagactccct	6	14	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:14633975C>T	uc001rbw.2	+	13	3294	c.3136C>T	c.(3136-3138)CAG>TAG	p.Q1046*	ATF7IP_uc001rbv.1_Nonsense_Mutation_p.Q1045*|ATF7IP_uc001rbx.2_Nonsense_Mutation_p.Q1045*|ATF7IP_uc001rby.3_Nonsense_Mutation_p.Q1046*|ATF7IP_uc001rca.2_Nonsense_Mutation_p.Q1046*	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1046					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TCCAGTAACTCAGGTGACCAC	0.453													0	0	0	0.139131	0	37	40										T	14633975	C	T	14633975	4	4	37	1	0	0	0	0	0	1	0	0	1087	827	29	1	3182	1	ATF7IP	12	14633975	Nonsense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	7674328	14633975	119217920	163	9172										
YAF2	10138	broad.mit.edu	37	chr12	42554413	42554413	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatgagattctccattcaatGatgaggcttctcctctgggt	9	9	4	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:42554413G>A	uc001rmv.2	-	4	589	c.521C>T	c.(520-522)TCA>TTA	p.S174L	YAF2_uc001rmw.2_Missense_Mutation_p.S198L|YAF2_uc010sko.1_Missense_Mutation_p.S165L|YAF2_uc010skp.1_Missense_Mutation_p.S132L	NM_005748	NP_005739	Q8IY57	YAF2_HUMAN	YY1 associated factor 2	174					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|zinc ion binding				0	all_cancers(12;0.000425)	Lung NSC(34;0.0402)|all_lung(34;0.057)		GBM - Glioblastoma multiforme(48;0.0514)		TCCATTCAATGATGAGGCTTC	0.423													0	0	0	0.058154	0	8	6										A	42554413	G	A	42554413	3	1	37	1	0	0	0	0	1	0	0	0	17462	1294	45	1	25	1	YAF2	12	42554413	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	27920438	42554413	91297482	164	9173										
KRT6C	286887	broad.mit.edu	37	chr12	52865005	52865006	+	Missense_Mutation	DNP	GG	GG	TT													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctcagcgatgatgctgtccaGgtccaggttgcggttgttgt							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:52865005_52865006GG>TT	uc001sal.3	-	5	1035_1036	c.987_988CC>AA	c.(985-990)GACCTG>GAAATG	p.329_330DL>EM		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	329_330	Rod.|Linker 12.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		ATGCTGTCCAGGTCCAGGTTGC	0.559													0	0	0	0.115264	0	75	107										TT	52865006	GG	TT	52865005	3	4	37	1	0	0	0	0	1	0	0	0	8482	991	35	4	726	4	KRT6C	12	52865005	Missense_Mutation	DNP	GG	TCGA-CU-A3KJ-01A-11D-A21A-08	10310592	52865005	80986890	165	9174										
PAN2	9924	broad.mit.edu	37	chr12	56718262	56718262	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aggaatagtacggaatgcccGaagaaaattattgccctgga	11	7	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:56718262G>A	uc001skx.2	-	12	2117	c.1744C>T	c.(1744-1746)CGG>TGG	p.R582W	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.R582W|PAN2_uc001sky.2_Missense_Mutation_p.R582W	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	582					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CGGAATGCCCGAAGAAAATTA	0.498													0	0	0	0.058154	0	10	5										A	56718262	G	A	56718262	3	1	37	1	0	0	0	0	1	0	0	0	11414	1057	37	1	1924	1	PAN2	12	56718262	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	3853257	56718262	77133633	166	9175										
HAL	3034	broad.mit.edu	37	chr12	96368046	96368046	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tccgggattttggtggatttCttgtgcagaaattgcagtga	13	5	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:96368046C>T	uc001tem.1	-	21	2235	c.1938G>A	c.(1936-1938)AAG>AAA	p.K646K	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Silent_p.K438K|HAL_uc010sux.1_3'UTR	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	646					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	TGGTGGATTTCTTGTGCAGAA	0.438													0	0	0	0.069288	0	20	61										T	96368046	C	T	96368046	2	4	37	1	0	0	0	0	0	0	0	1	6947	912	32	1		1	HAL	12	96368046	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	39649784	96368046	37483849	167	9176										
ASCL1	429	broad.mit.edu	37	chr12	103352354	103352354	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cttcagcggctttggctacaGcctgccgcagcagcagccgg	13	15	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:103352354G>T	uc001tjr.3	+	1	903	c.332G>T	c.(331-333)AGC>ATC	p.S111I		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	111					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						TTTGGCTACAGCCTGCCGCAG	0.662													1	0	7.07596e-05	0.175082	7.16332e-05	15	9										T	103352354	G	T	103352354	3	4	37	1	0	0	0	0	1	0	0	0	1034	971	34	4	334	4	ASCL1	12	103352354	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	6984308	103352354	30499541	168	9177										
HSP90B1	7184	broad.mit.edu	37	chr12	104341191	104341191	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tggatgtgggaacagatgaaGaagaagaaacagcaaaggta	14	3	0	5			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:104341191G>A	uc001tkb.1	+	17	2470	c.2365G>A	c.(2365-2367)GAA>AAA	p.E789K	HSP90B1_uc010swg.1_Missense_Mutation_p.E454K|HSP90B1_uc009zui.1_Silent_p.K325K	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	789					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	aacagatgaagaagaagaaAC	0.184													0	0	0	0.105934	0	14	9										A	104341191	G	A	104341191	3	1	37	1	0	0	0	0	1	0	0	0	7403	943	33	1	2431	1	HSP90B1	12	104341191	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	988837	104341191	29510704	169	9178										
ZNF10	7556	broad.mit.edu	37	chr12	133732691	133732691	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttactaggcatcagcttattCatactggagaaaaaccctat	6	9	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:133732691C>T	uc009zzb.2	+	5	1306	c.859C>T	c.(859-861)CAT>TAT	p.H287Y	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.H287Y	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	287	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TCAGCTTATTCATACTGGAGA	0.418													0	0	0	0.09319	0	9	55										T	133732691	C	T	133732691	3	4	37	1	0	0	0	0	1	0	0	0	17709	826	29	1	873	1	ZNF10	12	133732691	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	29391500	133732691	119204	170	9179										
FREM2	341640	broad.mit.edu	37	chr13	39438670	39438670	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaacctagaggcctgtttatGggagttcgttagctactatg	12	7	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:39438670G>A	uc001uwv.2	+	16	8219	c.7910G>A	c.(7909-7911)TGG>TAG	p.W2637*	FREM2_uc001uww.2_Nonsense_Mutation_p.W723*	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2637	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCTGTTTATGGGAGTTCGTT	0.458													0	0	0	0.062417	0	20	27										A	39438670	G	A	39438670	4	1	37	1	0	0	0	0	0	1	0	0	6045	1357	47	2	7972	2	FREM2	13	39438670	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		39438670	75731208	171	9180										
KBTBD6	89890	broad.mit.edu	37	chr13	41705613	41705613	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gggtgtccaaagaagatcacCatctccttggcacacatacc	8	13	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:41705613C>A	uc001uxu.1	-	1	1324	c.1035G>T	c.(1033-1035)ATG>ATT	p.M345I	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.M279I|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	345							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AGAAGATCACCATCTCCTTGG	0.448													1	0	0.000673444	0.069234	0.000677576	5	63										A	41705613	C	A	41705613	3	1	37	1	0	0	0	0	1	0	0	0	7997	594	21	4	993	4	KBTBD6	13	41705613	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2266943	41705613	73464265	172	9181										
KBTBD7	84078	broad.mit.edu	37	chr13	41767359	41767359	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggatgtccaaagaagatcacCatctccttggcacacatacc	7	13	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:41767359C>A	uc001uxw.1	-	1	1344	c.1035G>T	c.(1033-1035)ATG>ATT	p.M345I	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	345							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		AGAAGATCACCATCTCCTTGG	0.428													1	0	5.03518e-11	0.189662	5.27649e-11	11	13										A	41767359	C	A	41767359	3	1	37	1	0	0	0	0	1	0	0	0	7998	594	21	4	1023	4	KBTBD7	13	41767359	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	61746	41767359	73402519	173	9182										
SLC25A30	253512	broad.mit.edu	37	chr13	45973211	45973211	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccagaccacaggtgaagcttGagctataaagacaccattgg	10	10	0	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:45973211G>C	uc001vag.2	-	8	754	c.617C>G	c.(616-618)TCA>TGA	p.S206*	SLC25A30_uc010tfs.1_Nonsense_Mutation_p.S131*|SLC25A30_uc001vah.2_Nonsense_Mutation_p.S131*|SLC25A30_uc010tft.1_Nonsense_Mutation_p.S155*|SLC25A30_uc001vaf.2_Nonsense_Mutation_p.S62*	NM_001010875	NP_001010875	Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	206	Helical; Name=5; (Potential).|Solcar 3.				mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		GGTGAAGCTTGAGCTATAAAG	0.463													0	0	0	0.047766	0	7	34										C	45973211	G	C	45973211	4	2	37	1	0	0	0	0	0	1	0	0	14494	1294	45	1	270	1	SLC25A30	13	45973211	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	4205852	45973211	69196667	174	9183										
ESD	2098	broad.mit.edu	37	chr13	47365491	47365491	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	taatagttacctgtcatgttCaaaaactttctgcaatcccc	4	11	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:47365491C>T	uc001vbn.2	-	3	241	c.58G>A	c.(58-60)GAA>AAA	p.E20K	ESD_uc001vbo.2_Missense_Mutation_p.E20K	NM_001984	NP_001975	P10768	ESTD_HUMAN	esterase D/formylglutathione hydrolase	20						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			ovary(1)	1		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	CTGTCATGTTCAAAAACTTTC	0.303													0	0	0	0.189662	0	13	12										T	47365491	C	T	47365491	3	4	37	1	0	0	0	0	1	0	0	0	5250	835	29	1	822	1	ESD	13	47365491	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1392280	47365491	67804387	175	9184										
FNDC3A	22862	broad.mit.edu	37	chr13	49762735	49762735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aggctgtttctatcgtttacGagtttactgcatcagtgatg	10	7	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:49762735G>A	uc001vcm.2	+	17	2215	c.1910G>A	c.(1909-1911)CGA>CAA	p.R637Q	FNDC3A_uc001vcn.2_Missense_Mutation_p.R637Q|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.R563Q|FNDC3A_uc001vcq.2_Missense_Mutation_p.R581Q	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	637	Fibronectin type-III 4.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TATCGTTTACGAGTTTACTGC	0.413													0	0	0	0.134883	0	24	157										A	49762735	G	A	49762735	3	1	37	1	0	0	0	0	1	0	0	0	5969	1058	37	1	1983	1	FNDC3A	13	49762735	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2397244	49762735	65407143	176	9185										
EDNRB	1910	broad.mit.edu	37	chr13	78477333	78477333	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acgggatgaagcaagcagatTcgcagataacttcctttgta	10	8	0	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:78477333T>C	uc001vko.2	-	3	1017	c.759A>G	c.(757-759)CGA>CGG	p.R253R	EDNRB_uc001vkq.1_Silent_p.R253R|uc001vkn.1_Intron|EDNRB_uc010aez.1_Silent_p.R253R|EDNRB_uc001vkp.1_Silent_p.R336R	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	253	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GCAAGCAGATTCGCAGATAAC	0.373													0	0	0	0.163468	0	23	34										C	78477333	T	C	78477333	2	2	37	1	0	0	0	0	0	0	0	1	4920	1770	62	5		5	EDNRB	13	78477333	Silent	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	28714598	78477333	36692545	177	9186										
OR4E2	26686	broad.mit.edu	37	chr14	22134223	22134223	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagagacaagtttttttcacGaaatcatatacataatgggc	7	7	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:22134223G>A	uc010tmd.1	+	1	927	c.927G>A	c.(925-927)ACG>ACA	p.T309T		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TTTTTTTCACGAAATCATATA	0.393													0	0	0	0.150653	0	4	11										A	22134223	G	A	22134223	2	1	37	1	0	0	0	0	0	0	0	1	11060	1045	37	1		1	OR4E2	14	22134223	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		22134223	85215317	178	9187										
SCFD1	23256	broad.mit.edu	37	chr14	31169416	31169416	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggaactccagaagataaaatGaggttgtttcttatctatta	8	5	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:31169416G>C	uc001wqm.1	+	16	1386	c.1362G>C	c.(1360-1362)ATG>ATC	p.M454I	SCFD1_uc001wqn.1_Missense_Mutation_p.M387I|SCFD1_uc010tpg.1_Missense_Mutation_p.M395I|SCFD1_uc010tph.1_Missense_Mutation_p.M269I|SCFD1_uc010amf.1_Missense_Mutation_p.M269I|SCFD1_uc010tpi.1_Missense_Mutation_p.M362I|SCFD1_uc010amd.1_Missense_Mutation_p.M286I|SCFD1_uc010ame.1_Missense_Mutation_p.M387I	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	454					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AAGATAAAATGAGGTTGTTTC	0.348													0	0	0	0.099896	0	20	37										C	31169416	G	C	31169416	3	2	37	1	0	0	0	0	1	0	0	0	13889	1290	45	1	1424	1	SCFD1	14	31169416	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	9035193	31169416	76180124	179	9188										
PTGER2	5732	broad.mit.edu	37	chr14	52781491	52781491	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtgctggtgaccgagctggtGttcaccgacctgctcgggac	15	12	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:52781491G>A	uc001wzr.2	+	1	476	c.225G>A	c.(223-225)GTG>GTA	p.V75V		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	75	Helical; Name=2; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CCGAGCTGGTGTTCACCGACC	0.711													0	0	0	0.062417	0	18	60										A	52781491	G	A	52781491	2	1	37	1	0	0	0	0	0	0	0	1	12743	1364	48	2		2	PTGER2	14	52781491	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	21612075	52781491	54568049	180	9189										
SPTB	6710	broad.mit.edu	37	chr14	65260362	65260362	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttgtgcttgcgctgtaagatGagcacactggtcaggtcttt	12	8	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:65260362G>C	uc001xht.2	-	13	2073	c.2019C>G	c.(2017-2019)CTC>CTG	p.L673L	SPTB_uc001xhr.2_Silent_p.L673L|SPTB_uc001xhs.2_Silent_p.L673L|SPTB_uc001xhu.2_Silent_p.L673L	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	673	Spectrin 4.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCTGTAAGATGAGCACACTGG	0.547													0	0	0	0.080935	0	11	22										C	65260362	G	C	65260362	2	2	37	1	0	0	0	0	0	0	0	1	15117	1277	45	1		1	SPTB	14	65260362	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	12478871	65260362	42089178	181	9190										
C14orf174	161394	broad.mit.edu	37	chr14	77843846	77843846	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggcctgaactgcctggacttCataaattgtatgaaaatgcc	9	9	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:77843846C>T	uc001xtq.1	+	1	85	c.85C>T	c.(85-87)CAT>TAT	p.H29Y	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	29											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GCCTGGACTTCATAAATTGTA	0.517													0	0	0	0.146539	0	15	21										T	77843846	C	T	77843846	3	4	37	1	0	0	0	0	1	0	0	0	1759	826	29	1	87	1	C14orf174	14	77843846	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	12583484	77843846	29505694	182	9191										
FLRT2	23768	broad.mit.edu	37	chr14	86087957	86087957	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tactcacaggtgtccaaactCctggcctgccctagtgtgtg	10	13	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86087957C>G	uc001xvr.2	+	2	866	c.99C>G	c.(97-99)CTC>CTG	p.L33L	FLRT2_uc010atd.2_Silent_p.L33L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	33					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGTCCAAACTCCTGGCCTGCC	0.547													0	0	0	0.139131	0	53	50										G	86087957	C	G	86087957	2	3	37	1	0	0	0	0	0	0	0	1	5939	842	30	1		1	FLRT2	14	86087957	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	8244111	86087957	21261583	183	9192			2	32		3	3	906	N	G_C	3.164434e-05
FLRT2	23768	broad.mit.edu	37	chr14	86088062	86088062	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccggagggcgtaactgtactCtacctccacaacaaccaaat	7	14	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86088062C>G	uc001xvr.2	+	2	971	c.204C>G	c.(202-204)CTC>CTG	p.L68L	FLRT2_uc010atd.2_Silent_p.L68L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	68	Extracellular (Potential).|LRR 1.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TAACTGTACTCTACCTCCACA	0.517													0	0	0	0.139131	0	66	49										G	86088062	C	G	86088062	2	3	37	1	0	0	0	0	0	0	0	1	5939	900	32	1		1	FLRT2	14	86088062	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	105	86088062	21261478	184	9193			2	32		3	3	906	N	G_C	3.164434e-05
FLRT2	23768	broad.mit.edu	37	chr14	86088862	86088862	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cccttcatctctcaacgtgcGgggtttcatgtgccaaggtc	10	13	4	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86088862G>T	uc001xvr.2	+	2	1771	c.1004G>T	c.(1003-1005)CGG>CTG	p.R335L	FLRT2_uc010atd.2_Missense_Mutation_p.R335L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	335	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CTCAACGTGCGGGGTTTCATG	0.507													1	0	4.44732e-65	0.139131	4.78269e-65	87	93										T	86088862	G	T	86088862	3	4	37	1	0	0	0	0	1	0	0	0	5939	1116	39	4	1006	4	FLRT2	14	86088862	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	800	86088862	21260678	185	9194			2	32		3	3	906	N	G_C	3.164434e-05
KCNK13	56659	broad.mit.edu	37	chr14	90650720	90650720	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtgtactacgtcatgctgatCctatgcacagcctccatcct	7	14	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650720C>G	uc001xye.1	+	2	1042	c.600C>G	c.(598-600)ATC>ATG	p.I200M		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	200	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TCATGCTGATCCTATGCACAG	0.592													0	0	0	0.09836	0	32	162										G	90650720	C	G	90650720	3	3	37	1	0	0	0	0	1	0	0	0	8061	845	30	1	606	1	KCNK13	14	90650720	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	4561858	90650720	16698820	186	9195			3	33	4561858	4	4	250	C		1.740648e-09
KCNK13	56659	broad.mit.edu	37	chr14	90650738	90650738	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atcctatgcacagcctccatCctcatctcttgctgcgcctc	5	18	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650738C>T	uc001xye.1	+	2	1060	c.618C>T	c.(616-618)ATC>ATT	p.I206I		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	206	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CAGCCTCCATCCTCATCTCTT	0.562													0	0	0	0.124865	0	34	162										T	90650738	C	T	90650738	2	4	37	1	0	0	0	0	0	0	0	1	8061	845	30	1		1	KCNK13	14	90650738	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	18	90650738	16698802	187	9196			3	33	4561858	4	4	250	C		1.740648e-09
KCNK13	56659	broad.mit.edu	37	chr14	90650948	90650948	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgctgcatctactccttgttCaatgtcatctctatcctcat	4	13	5	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650948C>G	uc001xye.1	+	2	1270	c.828C>G	c.(826-828)TTC>TTG	p.F276L		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	276	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				ACTCCTTGTTCAATGTCATCT	0.522													0	0	0	0.153744	0	23	78										G	90650948	C	G	90650948	3	3	37	1	0	0	0	0	1	0	0	0	8061	825	29	1	834	1	KCNK13	14	90650948	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	210	90650948	16698592	188	9197			3	33	4561858	4	4	250	C		1.740648e-09
KCNK13	56659	broad.mit.edu	37	chr14	90650969	90650969	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aatgtcatctctatcctcatCaaacagtccttgaactggat	5	11	4	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650969C>G	uc001xye.1	+	2	1291	c.849C>G	c.(847-849)ATC>ATG	p.I283M		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	283	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CTATCCTCATCAAACAGTCCT	0.517													0	0	0	0.173368	0	26	94										G	90650969	C	G	90650969	3	3	37	1	0	0	0	0	1	0	0	0	8061	816	29	1	855	1	KCNK13	14	90650969	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	21	90650969	16698571	189	9198			3	33	4561858	4	4	250	C		1.740648e-09
GOLGA5	9950	broad.mit.edu	37	chr14	93299516	93299516	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcagtctgagttagaaaatcGactccatcagctaacagaga	8	9	3	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:93299516G>A	uc001yaz.1	+	10	1951	c.1769G>A	c.(1768-1770)CGA>CAA	p.R590Q	GOLGA5_uc001yba.1_5'UTR	NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	590	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		TTAGAAAATCGACTCCATCAG	0.403			T	RET	papillary thyroid								0	0	0	0.146539	0	12	38										A	93299516	G	A	93299516	3	1	37	1	0	0	0	0	1	0	0	0	6556	1058	37	1	1803	1	GOLGA5	14	93299516	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2648547	93299516	14050024	190	9199										
SLC25A29	123096	broad.mit.edu	37	chr14	100758860	100758860	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atgccgcggtagcgcggggcGccccgcagtccgtccgcctg	16	17	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:100758860G>A	uc001yha.2	-	4	963	c.672C>T	c.(670-672)GGC>GGT	p.G224G	SLC25A29_uc010avv.2_Silent_p.G158G|SLC25A29_uc010twx.1_Missense_Mutation_p.A202V	NM_001039355	NP_001034444	Q8N8R3	MCATL_HUMAN	solute carrier family 25, member 29	224	Solcar 3.					integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1		Melanoma(154;0.152)			L-Carnitine(DB00583)	AGCGCGGGGCGCCCCGCAGTC	0.706													0	0	0	0.047766	0	7	19										A	100758860	G	A	100758860	2	1	37	1	0	0	0	0	0	0	0	1	14492	1074	38	2		2	SLC25A29	14	100758860	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	7459344	100758860	6590680	191	9200										
CYFIP1	23191	broad.mit.edu	37	chr15	22955190	22955190	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gagacggggcatgagcccttCaatgacccagccttgcgggg	15	12	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:22955190C>A	uc001yus.2	+	15	1688	c.1584C>A	c.(1582-1584)TTC>TTA	p.F528L	CYFIP1_uc001yut.2_Missense_Mutation_p.F528L|CYFIP1_uc010aya.1_Missense_Mutation_p.F556L|CYFIP1_uc001yuu.2_5'Flank	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	528					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ATGAGCCCTTCAATGACCCAG	0.622													1	0	4.44401e-20	0.117977	4.748e-20	33	49										A	22955190	C	A	22955190	3	1	37	1	0	0	0	0	1	0	0	0	4137	825	29	3	1638	3	CYFIP1	15	22955190	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		22955190	79576202	192	9201										
RYR3	6263	broad.mit.edu	37	chr15	33928729	33928729	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aaaggctctgaacttgccttCgctgactacgagattgagaa	10	9	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:33928729C>T	uc001zhi.2	+	27	3604	c.3534C>T	c.(3532-3534)TTC>TTT	p.F1178F	RYR3_uc010bar.2_Silent_p.F1178F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1178	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AACTTGCCTTCGCTGACTACG	0.493													0	0	0	0.09319	0	11	54										T	33928729	C	T	33928729	2	4	37	1	0	0	0	0	0	0	0	1	13770	883	31	1		1	RYR3	15	33928729	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	10973539	33928729	68602663	193	9202										
RYR3	6263	broad.mit.edu	37	chr15	33936718	33936718	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caaaggatcatccacacataGaggtaatgttacacaatgtg	8	8	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:33936718G>C	uc001zhi.2	+	28	3833	c.3763G>C	c.(3763-3765)GAG>CAG	p.E1255Q	RYR3_uc010bar.2_Missense_Mutation_p.E1255Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1255	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCACACATAGAGGTAATGTT	0.512													0	0	0	0.02938	0	6	13										C	33936718	G	C	33936718	3	2	37	1	0	0	0	0	1	0	0	0	13770	943	33	1	3873	1	RYR3	15	33936718	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	7989	33936718	68594674	194	9203										
RYR3	6263	broad.mit.edu	37	chr15	34151822	34151822	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	agtgagagcaggaggtggcaTtggtgatgaaattgaagacc	16	4	0	5			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:34151822T>G	uc001zhi.2	+	100	14259	c.14189T>G	c.(14188-14190)ATT>AGT	p.I4730S	RYR3_uc010bar.2_Missense_Mutation_p.I4725S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4730	Helical; Name=M9; (Potential).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGAGGTGGCATTGGTGATGAA	0.423													0	0	0	0.069234	0	9	29										G	34151822	T	G	34151822	3	3	37	1	0	0	0	0	1	0	0	0	13770	1493	52	5	14587	5	RYR3	15	34151822	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	215104	34151822	68379570	195	9204										
CASC5	57082	broad.mit.edu	37	chr15	40913375	40913375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccagtgagaccaactcacggGaatctaaaggtaatgatatt	9	8	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:40913375G>A	uc010bbs.1	+	11	1152	c.991G>A	c.(991-993)GAA>AAA	p.E331K	CASC5_uc010ucq.1_Missense_Mutation_p.E155K|CASC5_uc001zme.2_Missense_Mutation_p.E305K|CASC5_uc010bbt.1_Missense_Mutation_p.E305K	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	331	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAACTCACGGGAATCTAAAGG	0.378													0	0	0	0.069234	0	10	26										A	40913375	G	A	40913375	3	1	37	1	0	0	0	0	1	0	0	0	2663	1175	41	1	1029	1	CASC5	15	40913375	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	6761553	40913375	61618017	196	9205										
INO80	54617	broad.mit.edu	37	chr15	41365655	41365655	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtgaatatggtaagcattttCagcattcttcagggcctggg	12	7	3	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:41365655C>T	uc001zni.2	-	11	1579	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	456	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TAAGCATTTTCAGCATTCTTC	0.378													0	0	0	0.069234	0	6	49										T	41365655	C	T	41365655	3	4	37	1	0	0	0	0	1	0	0	0	7746	835	29	1	3408	1	INO80	15	41365655	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	452280	41365655	61165737	197	9206										
WDR76	79968	broad.mit.edu	37	chr15	44149340	44149340	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccacccagtgcatagacagtAttttatcactgccggattga	8	11	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:44149340A>G	uc001zti.1	+	10	1411	c.1388A>G	c.(1387-1389)TAT>TGT	p.Y463C		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	463	WD 4.										0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		CATAGACAGTATTTTATCACT	0.373													0	0	0	0.175082	0	12	16										G	44149340	A	G	44149340	3	3	37	1	0	0	0	0	1	0	0	0	17323	449	16	5	1426	5	WDR76	15	44149340	Missense_Mutation	SNP	A	TCGA-CU-A3KJ-01A-11D-A21A-08	2783685	44149340	58382052	198	9207										
DUOX2	50506	broad.mit.edu	37	chr15	45389939	45389939	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcagaagcacacctgtcataCctgggggcaggaagacaggg	15	10	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:45389939C>T	uc010bea.2	-	28	3769	c.3566G>A	c.(3565-3567)GGT>GAT	p.G1189D	DUOX2_uc001zun.2_Missense_Mutation_p.G1189D	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1189	Interaction with TXNDC11 (By similarity).|Helical; (Potential).|Ferric oxidoreductase.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ACCTGTCATACCTGGGGGCAG	0.587													0	0	0	0.204396	0	16	55										T	45389939	C	T	45389939	3	4	37	1	0	0	0	0	1	0	0	0	4801	521	18	2	1108	2	DUOX2	15	45389939	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1240599	45389939	57141453	199	9208										
PLEKHO2	80301	broad.mit.edu	37	chr15	65157389	65157389	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagaggaggacagtggctctGagcagcctcccaacagcgtc	13	13	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157389G>C	uc002anv.2	+	6	909	c.775G>C	c.(775-777)GAG>CAG	p.E259Q	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Missense_Mutation_p.E209Q	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	259	Pro-rich.									ovary(1)|lung(1)	2						CAGTGGCTCTGAGCAGCCTCC	0.632													0	0	0	0.144211	0	25	32										C	65157389	G	C	65157389	3	2	37	1	0	0	0	0	1	0	0	0	12085	1291	45	1	797	1	PLEKHO2	15	65157389	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	19767450	65157389	37374003	200	9209			4	34		3	3	526	G		1.066447e-05
PLEKHO2	80301	broad.mit.edu	37	chr15	65157595	65157595	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgaaagcctccatgggtgaGatgcaggcttctgggccacc	13	12	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157595G>C	uc002anv.2	+	6	1115	c.981G>C	c.(979-981)GAG>GAC	p.E327D	PLEKHO2_uc010bgz.2_Missense_Mutation_p.E3D|PLEKHO2_uc002anw.2_Missense_Mutation_p.E277D	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	327	Pro-rich.									ovary(1)|lung(1)	2						CCATGGGTGAGATGCAGGCTT	0.597													0	0	0	0.09319	0	8	21										C	65157595	G	C	65157595	3	2	37	1	0	0	0	0	1	0	0	0	12085	933	33	1	1003	1	PLEKHO2	15	65157595	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	206	65157595	37373797	201	9210			4	34		3	3	526	G		1.066447e-05
PLEKHO2	80301	broad.mit.edu	37	chr15	65157914	65157914	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgaacaaggtgctgggcagtGagccggcccctgttagtgcc	15	11	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157914G>A	uc002anv.2	+	6	1434	c.1300G>A	c.(1300-1302)GAG>AAG	p.E434K	PLEKHO2_uc010bgz.2_Missense_Mutation_p.E110K|PLEKHO2_uc002anw.2_Missense_Mutation_p.E384K	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	434										ovary(1)|lung(1)	2						GCTGGGCAGTGAGCCGGCCCC	0.602													0	0	0	0.144211	0	28	21										A	65157914	G	A	65157914	3	1	37	1	0	0	0	0	1	0	0	0	12085	1291	45	1	1322	1	PLEKHO2	15	65157914	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	319	65157914	37373478	202	9211			4	34		3	3	526	G		1.066447e-05
RASL12	51285	broad.mit.edu	37	chr15	65360144	65360144	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcgctctgaggcccgctgccCgcgcggggttttccaaacac	13	16	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65360144C>G	uc002aoi.1	-	1	245	c.30G>C	c.(28-30)GCG>GCC	p.A10A	RASL12_uc002aoj.1_Silent_p.A10A|RASL12_uc010uir.1_Intron	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	10					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						GCCCGCTGCCCGCGCGGGGTT	0.766													0	0	0	0.058154	0	8	11										G	65360144	C	G	65360144	2	3	37	1	0	0	0	0	0	0	0	1	13083	639	23	4		4	RASL12	15	65360144	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	202230	65360144	37171248	203	9212										
BBS4	585	broad.mit.edu	37	chr15	73007669	73007669	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaaggaaatatccaagaatcCctagaactcttccagacatg	7	10	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:73007669C>G	uc002avb.2	+	5	301	c.258C>G	c.(256-258)TCC>TCG	p.S86S	BBS4_uc010ukv.1_Silent_p.S74S|BBS4_uc002avc.2_5'UTR|BBS4_uc002avd.2_Silent_p.S94S	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	86	TPR 1.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						TCCAAGAATCCCTAGAACTCT	0.443									Bardet-Biedl_syndrome				0	0	0	0.132662	0	13	26										G	73007669	C	G	73007669	2	3	37	1	0	0	0	0	0	0	0	1	1339	610	22	4		4	BBS4	15	73007669	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	7647525	73007669	29523723	204	9213										
RASGRF1	5923	broad.mit.edu	37	chr15	79284125	79284125	+	Silent	SNP	C	C	T													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttttcaaagggctcagccttCacgccttcagcctggttttg							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284125C>T	uc002beq.2	-	22	3462	c.3087G>A	c.(3085-3087)GTG>GTA	p.V1029V	RASGRF1_uc002bep.2_Silent_p.V1013V|RASGRF1_uc010blm.1_Silent_p.V938V|RASGRF1_uc002ber.3_Silent_p.V1013V|RASGRF1_uc010unh.1_Silent_p.V424V|RASGRF1_uc002beo.2_Silent_p.V245V	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1031					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GCTCAGCCTTCACGCCTTCAG	0.542													0	0	0	0.047766	0	8	29										T	79284125	C	T	79284125	2	4	37	1	0	0	0	0	0	0	0	1	13072	813	29	1		1	RASGRF1	15	79284125	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	6276456	79284125	23247267	205	9214	45	2								
RASGRF1	5923	broad.mit.edu	37	chr15	79284133	79284133	+	Missense_Mutation	SNP	C	C	T													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gggctcagccttcacgccttCagcctggttttgagttgggg							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284133C>T	uc002beq.2	-	22	3454	c.3079G>A	c.(3079-3081)GAA>AAA	p.E1027K	RASGRF1_uc002bep.2_Missense_Mutation_p.E1011K|RASGRF1_uc010blm.1_Missense_Mutation_p.E936K|RASGRF1_uc002ber.3_Missense_Mutation_p.E1011K|RASGRF1_uc010unh.1_Missense_Mutation_p.E422K|RASGRF1_uc002beo.2_Missense_Mutation_p.E243K	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1029					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TTCACGCCTTCAGCCTGGTTT	0.547													0	0	0	0.02938	0	6	27										T	79284133	C	T	79284133	3	4	37	1	0	0	0	0	1	0	0	0	13072	835	29	1	770	1	RASGRF1	15	79284133	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	8	79284133	23247259	206	9215	45	2								
CPEB1	64506	broad.mit.edu	37	chr15	83218237	83218237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atacttgtgcttatctgtgtCaatcccggcatacaccactc	6	13	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:83218237C>G	uc002bit.2	-	9	1704	c.1567G>C	c.(1567-1569)GAC>CAC	p.D523H	CPEB1_uc002biq.2_Missense_Mutation_p.D383H|CPEB1_uc002bir.2_Missense_Mutation_p.D388H|CPEB1_uc002bis.2_Missense_Mutation_p.D383H|CPEB1_uc010uod.1_Missense_Mutation_p.D232H|CPEB1_uc010uoe.1_Missense_Mutation_p.D461H|CPEB1_uc002biu.2_Missense_Mutation_p.D485H|CPEB1_uc010uof.1_Missense_Mutation_p.D383H|CPEB1_uc002biv.2_Missense_Mutation_p.D458H|CPEB1_uc002bip.2_Missense_Mutation_p.D232H	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	463	RRM 2.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TTATCTGTGTCAATCCCGGCA	0.517													0	0	0	0.062417	0	16	41										G	83218237	C	G	83218237	3	3	37	1	0	0	0	0	1	0	0	0	3800	826	29	1	329	1	CPEB1	15	83218237	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3934104	83218237	19313155	207	9216										
GNPTG	84572	broad.mit.edu	37	chr16	1413046	1413046	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cgagacgcccagagccaagtCtccagagcagctgcggggtg	15	13	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:1413046C>T	uc002clm.2	+	11	907	c.872C>T	c.(871-873)TCT>TTT	p.S291F		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	291						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				AGAGCCAAGTCTCCAGAGCAG	0.622													0	0	0	0.09319	0	11	19										T	1413046	C	T	1413046	3	4	37	1	0	0	0	0	1	0	0	0	6546	913	32	1	914	1	GNPTG	16	1413046	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		1413046	88941707	208	9217										
TBL3	10607	broad.mit.edu	37	chr16	2024268	2024268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cattctggaagtggcctcggGggccgtgctgcggagtctgg	18	10	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:2024268G>A	uc002cnu.1	+	3	266	c.164G>A	c.(163-165)GGG>GAG	p.G55E	TBL3_uc002cnv.1_5'UTR|TBL3_uc010bsb.1_5'Flank|TBL3_uc010bsc.1_5'Flank|TBL3_uc010uvt.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	55					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						GTGGCCTCGGGGGCCGTGCTG	0.647													0	0	0	0.11126	0	38	83										A	2024268	G	A	2024268	3	1	37	1	0	0	0	0	1	0	0	0	15640	1232	43	2	174	2	TBL3	16	2024268	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	611222	2024268	88330485	209	9218										
DNAH3	55567	broad.mit.edu	37	chr16	20999096	20999096	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttaaagacgtaatgtgacttCgagggagttggcaagaagtt	13	4	0	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:20999096C>T	uc010vbe.1	-	46	6801	c.6801G>A	c.(6799-6801)TCG>TCA	p.S2267S	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2267	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AATGTGACTTCGAGGGAGTTG	0.493													0	0	0	0.193644	0	29	12										T	20999096	C	T	20999096	2	4	37	1	0	0	0	0	0	0	0	1	4603	871	31	1		1	DNAH3	16	20999096	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	18974828	20999096	69355657	210	9219										
EEF2K	29904	broad.mit.edu	37	chr16	22291646	22291646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgatgctggccagggaggccGagatgctgttcacaggaggc	17	9	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:22291646G>A	uc002dki.2	+	17	2502	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	673					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		CAGGGAGGCCGAGATGCTGTT	0.637													0	0	0	0.163468	0	28	18										A	22291646	G	A	22291646	3	1	37	1	0	0	0	0	1	0	0	0	4930	1059	37	1	2079	1	EEF2K	16	22291646	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1292550	22291646	68063107	211	9220										
PRRT2	112476	broad.mit.edu	37	chr16	29824403	29824403	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccagcagctctgagatctctGagatgaagggggttgaggag	16	7	2	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:29824403G>C	uc002due.3	+	2	329	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.E10Q|PRRT2_uc002duf.1_Missense_Mutation_p.E10Q	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	10	Extracellular (Potential).				response to biotic stimulus	integral to membrane					0						TGAGATCTCTGAGATGAAGGG	0.587													0	0	0	0.108266	0	24	78										C	29824403	G	C	29824403	3	2	37	1	0	0	0	0	1	0	0	0	12610	1291	45	1	30	1	PRRT2	16	29824403	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	7532757	29824403	60530350	212	9221										
FTO	79068	broad.mit.edu	37	chr16	53967927	53967927	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgcttcatgaagttaaaagaGaggggctccccgtggaacaa	12	8	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:53967927G>C	uc002ehr.2	+	8	1492	c.1270G>C	c.(1270-1272)GAG>CAG	p.E424Q	FTO_uc010vha.1_Missense_Mutation_p.E128Q|FTO_uc010cbz.2_Missense_Mutation_p.E25Q|FTO_uc002ehs.2_RNA	NM_001080432	NP_001073901	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	424					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGTTAAAAGAGAGGGGCTCCC	0.418													0	0	0	0.146539	0	12	25										C	53967927	G	C	53967927	3	2	37	1	0	0	0	0	1	0	0	0	6086	943	33	1	1300	1	FTO	16	53967927	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	24143524	53967927	36386826	213	9222										
GPR97	222487	broad.mit.edu	37	chr16	57714456	57714456	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccacggtgcatatcctcacaCgcatctcccaggcgggctgt	10	16	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:57714456C>A	uc002emh.2	+	8	911	c.808C>A	c.(808-810)CGC>AGC	p.R270S	GPR97_uc010vhv.1_Missense_Mutation_p.R150S|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_5'UTR	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	270	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						TATCCTCACACGCATCTCCCA	0.577													1	0	1.96642e-18	0.092188	2.09411e-18	31	86										A	57714456	C	A	57714456	3	1	37	1	0	0	0	0	1	0	0	0	6720	536	19	4	838	4	GPR97	16	57714456	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3746529	57714456	32640297	214	9223										
KCTD19	146212	broad.mit.edu	37	chr16	67331452	67331452	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cttggctccagatgagtcttCaaagcaactttgattggctc	9	10	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:67331452C>T	uc002esu.2	-	7	1152	c.1101G>A	c.(1099-1101)TTG>TTA	p.L367L	KCTD19_uc002est.2_Silent_p.L139L|KCTD19_uc010vjj.1_Silent_p.L110L	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	367						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GATGAGTCTTCAAAGCAACTT	0.493													0	0	0	0.146539	0	17	30										T	67331452	C	T	67331452	2	4	37	1	0	0	0	0	0	0	0	1	8106	825	29	1		1	KCTD19	16	67331452	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	9616996	67331452	23023301	215	9224										
RLTPR	146206	broad.mit.edu	37	chr16	67685194	67685194	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cgccaggccgaggatgccatCcaaaatgccaacttctctct	8	15	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:67685194C>T	uc002etn.2	+	23	2409	c.2289C>T	c.(2287-2289)ATC>ATT	p.I763I	RLTPR_uc010cel.1_Silent_p.I756I|RLTPR_uc010vjr.1_Silent_p.I727I|RLTPR_uc010vjs.1_5'Flank	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	763										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		AGGATGCCATCCAAAATGCCA	0.587													0	0	0	0.139131	0	42	86										T	67685194	C	T	67685194	2	4	37	1	0	0	0	0	0	0	0	1	13394	845	30	1		1	RLTPR	16	67685194	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	353742	67685194	22669559	216	9225										
ZNF594	84622	broad.mit.edu	37	chr17	5086617	5086617	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cactgtggagtctctggtgtTcagtaaggtgagaatgctgc	14	7	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:5086617T>C	uc010cla.1	-	2	1091	c.935A>G	c.(934-936)GAA>GGA	p.E312G		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	312	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCTCTGGTGTTCAGTAAGGTG	0.453													0	0	0	0.069288	0	21	25										C	5086617	T	C	5086617	3	2	37	1	0	0	0	0	1	0	0	0	18021	1783	62	5	1492	5	ZNF594	17	5086617	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08		5086617	76108593	217	9226										
TP53	7157	broad.mit.edu	37	chr17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	actgcttgtagatggccatgGcgcggacgcgggtgccgggc	18	11	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:7578454G>A	uc002gim.2	-	5	670	c.476C>T	c.(475-477)GCC>GTC	p.A159V	TP53_uc002gig.1_Missense_Mutation_p.A159V|TP53_uc002gih.2_Missense_Mutation_p.A159V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27V|TP53_uc010cng.1_Missense_Mutation_p.A27V|TP53_uc002gii.1_Missense_Mutation_p.A27V|TP53_uc010cnh.1_Missense_Mutation_p.A159V|TP53_uc010cni.1_Missense_Mutation_p.A159V|TP53_uc002gij.2_Missense_Mutation_p.A159V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66V|TP53_uc002gio.2_Missense_Mutation_p.A27V|TP53_uc010vug.1_Missense_Mutation_p.A120V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.139131	0	63	19										A	7578454	G	A	7578454	3	1	37	1	0	0	0	0	1	0	0	0	16378	1203	42	2	822	2	TP53	17	7578454	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2491837	7578454	73616756	218	9227										
ODF4	146852	broad.mit.edu	37	chr17	8248778	8248778	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cattggttggctggtgcttaTcctatacttcacctgcggtg	11	10	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:8248778T>C	uc002gle.1	+	2	754	c.572T>C	c.(571-573)ATC>ACC	p.I191T		NM_153007	NP_694552	Q2M2E3	ODFP4_HUMAN	outer dense fiber of sperm tails 4	191	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)	1						CTGGTGCTTATCCTATACTTC	0.532													0	0	0	0.139131	0	75	30										C	8248778	T	C	8248778	3	2	37	1	0	0	0	0	1	0	0	0	10833	1435	50	5	578	5	ODF4	17	8248778	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	670324	8248778	72946432	219	9228										
MAP2K3	5606	broad.mit.edu	37	chr17	21207742	21207742	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgtccctccctggcagatgtGaagccctccaatgtccttat	8	14	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:21207742G>A	uc002gys.2	+	8	838	c.573G>A	c.(571-573)GTG>GTA	p.V191V	MAP2K3_uc002gyt.2_Silent_p.V162V|MAP2K3_uc002gyu.2_Silent_p.V162V	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	191	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TGGCAGATGTGAAGCCCTCCA	0.577													0	0	0	0.117977	0	36	95										A	21207742	G	A	21207742	2	1	37	1	0	0	0	0	0	0	0	1	9238	1277	45	1		1	MAP2K3	17	21207742	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	12958964	21207742	59987468	220	9229										
KSR1	8844	broad.mit.edu	37	chr17	25932610	25932610	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	aggagtgggacatccccttcGagcaggtagagctgggcgag	17	9	0	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:25932610G>C	uc010crg.2	+	15	1865	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	KSR1_uc002gzj.1_RNA|KSR1_uc002gzm.2_Missense_Mutation_p.E253Q	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	609					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CATCCCCTTCGAGCAGGTAGA	0.711													0	0	0	0.115264	0	3	10										C	25932610	G	C	25932610	3	2	37	1	0	0	0	0	1	0	0	0	8581	1059	37	1	1466	1	KSR1	17	25932610	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	4724868	25932610	55262600	221	9230										
GIT1	28964	broad.mit.edu	37	chr17	27909075	27909075	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagaggtgtggtgcccttctCtgggtggaagaagttggcct	16	8	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:27909075C>T	uc002hef.2	-	5	707	c.493G>A	c.(493-495)GAG>AAG	p.E165K	GIT1_uc002heg.2_Missense_Mutation_p.E165K|GIT1_uc010wbg.1_Missense_Mutation_p.E165K|GIT1_uc010csb.1_Missense_Mutation_p.E165K	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	165					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GTGCCCTTCTCTGGGTGGAAG	0.617													0	0	0	0.214465	0	36	29										T	27909075	C	T	27909075	3	4	37	1	0	0	0	0	1	0	0	0	6396	922	32	1	1887	1	GIT1	17	27909075	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1976465	27909075	53286135	222	9231										
SLFN12L	342615	broad.mit.edu	37	chr17	33806620	33806620	+	Frame_Shift_Del	DEL	A	A	-													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	taaccaagttctgttctgttAaaaaaatcagcagccaaggc							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:33806620delA	uc002hjn.2	-	3	1575	c.696delT	c.(694-696)TTTfs	p.F232fs		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						CTGTTCTGTTAAAAAAATCAG	0.368																		2	4	---	---								-	33806620	A	-	33806620	7	5	37	1	0	1	0	1	0	0	0	0	14735	359	13	0	1169	0	SLFN12L	17	33806620	Frame_Shift_Del	DEL	A	TCGA-CU-A3KJ-01A-11D-A21A-08	5897545	33806620	47388590	223	9232										
ACACA	31	broad.mit.edu	37	chr17	35549207	35549207	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagctctaactggaaagccaGagcaggctccagatgacgat	11	11	1	3	rs148729289	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:35549207G>C	uc002hnm.2	-	37	4320	c.4129C>G	c.(4129-4131)CTG>GTG	p.L1377V	ACACA_uc002hnk.2_Missense_Mutation_p.L1299V|ACACA_uc002hnl.2_Missense_Mutation_p.L1319V|ACACA_uc002hnn.2_Missense_Mutation_p.L1377V|ACACA_uc002hno.2_Missense_Mutation_p.L1414V|ACACA_uc010cuy.2_Missense_Mutation_p.L71V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1377					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGGAAAGCCAGAGCAGGCTCC	0.443													0	0	0	0.160694	0	14	29										C	35549207	G	C	35549207	3	2	37	1	0	0	0	0	1	0	0	0	106	933	33	1	2991	1	ACACA	17	35549207	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1742587	35549207	45646003	224	9233										
AFMID	125061	broad.mit.edu	37	chr17	76201688	76201688	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccactccccaccccagggagGacgctcagaggaatagcccc	10	18	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:76201688G>T	uc002jva.3	+	9	664	c.649G>T	c.(649-651)GAC>TAC	p.D217Y	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Missense_Mutation_p.D217Y	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	217						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CCCCAGGGAGGACGCTCAGAG	0.672													1	0	4.63292e-17	0.204396	4.90193e-17	19	57										T	76201688	G	T	76201688	3	4	37	1	0	0	0	0	1	0	0	0	362	1174	41	3	683	3	AFMID	17	76201688	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	40652481	76201688	4993522	225	9234										
DNAH17	8632	broad.mit.edu	37	chr17	76454708	76454708	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttgctgacacttgattttctCagctgttgctttttcaaacg	7	9	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:76454708C>G	uc010dhp.1	-	7	1138	c.916G>C	c.(916-918)GAG>CAG	p.E306Q	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTGATTTTCTCAGCTGTTGCT	0.522													0	0	0	0.080422	0	33	86										G	76454708	C	G	76454708	3	3	37	1	0	0	0	0	1	0	0	0	4601	835	29	1	3552	1	DNAH17	17	76454708	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	253020	76454708	4740502	226	9235										
C1QTNF1	114897	broad.mit.edu	37	chr17	77043906	77043906	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tacgtgcccggcctctacttCttcagcctcaacgtgcacac	7	17	4	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:77043906C>T	uc002jwp.2	+	4	922	c.582C>T	c.(580-582)TTC>TTT	p.F194F	C1QTNF1_uc002jwq.2_Silent_p.F112F|C1QTNF1_uc002jwr.3_Silent_p.F204F|C1QTNF1_uc002jws.2_Silent_p.F194F|C1QTNF1_uc002jwt.2_Silent_p.F292F	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	194	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GCCTCTACTTCTTCAGCCTCA	0.552													0	0	0	0.139131	0	82	69										T	77043906	C	T	77043906	2	4	37	1	0	0	0	0	0	0	0	1	1962	912	32	1		1	C1QTNF1	17	77043906	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	589198	77043906	4151304	227	9236										
METRNL	284207	broad.mit.edu	37	chr17	81043019	81043019	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tttatttggaaaaaactggaGaactgagactgctggtacca	10	6	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:81043019G>A	uc002kgh.2	+	2	501	c.376G>A	c.(376-378)GAA>AAA	p.E126K	METRNL_uc002kgi.2_Missense_Mutation_p.E44K	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	126						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AAAAACTGGAGAACTGAGACT	0.637													0	0	0	0.184627	0	4	66										A	81043019	G	A	81043019	3	1	37	1	0	0	0	0	1	0	0	0	9489	943	33	1	382	1	METRNL	17	81043019	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	3999113	81043019	152191	228	9237										
PTPRM	5797	broad.mit.edu	37	chr18	8088834	8088834	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gctgaaacctgcccacagcaGaggagcacctgtcaggtatg	12	12	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:8088834G>C	uc002knn.3	+	11	2344	c.1841G>C	c.(1840-1842)AGA>ACA	p.R614T	PTPRM_uc010dkv.2_Missense_Mutation_p.R614T|PTPRM_uc010wzl.1_Missense_Mutation_p.R401T	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	614	Fibronectin type-III 4.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCCCACAGCAGAGGAGCACCT	0.458													0	0	0	0.09836	0	38	15										C	8088834	G	C	8088834	3	2	37	1	0	0	0	0	1	0	0	0	12806	942	33	1	1883	1	PTPRM	18	8088834	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		8088834	69988414	229	9238										
GNAL	2774	broad.mit.edu	37	chr18	11868562	11868562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atgtcacagctatcatttacGtcgcagcctgcagtagctac	8	12	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:11868562G>A	uc010dkz.2	+	10	946	c.700G>A	c.(700-702)GTC>ATC	p.V234I	GNAL_uc002kqc.2_Missense_Mutation_p.V311I|GNAL_uc002kqd.2_Missense_Mutation_p.V234I|GNAL_uc010wzt.1_Missense_Mutation_p.V27I	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	234					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TATCATTTACGTCGCAGCCTG	0.463													0	0	0	0.124865	0	33	79										A	11868562	G	A	11868562	3	1	37	1	0	0	0	0	1	0	0	0	6507	1145	40	2	1114	2	GNAL	18	11868562	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	3779728	11868562	66208686	230	9239										
DSG1	1828	broad.mit.edu	37	chr18	28926024	28926024	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gagagagaatgacaggatttGaactaacagagggagttaaa	13	3	0	5			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:28926024G>C	uc002kwp.2	+	14	2175	c.1963G>C	c.(1963-1965)GAA>CAA	p.E655Q	DSG1_uc010xbp.1_Missense_Mutation_p.E14Q	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	655	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GACAGGATTTGAACTAACAGA	0.368													0	0	0	0.047766	0	7	28										C	28926024	G	C	28926024	3	2	37	1	0	0	0	0	1	0	0	0	4776	1291	45	1	2017	1	DSG1	18	28926024	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	17057462	28926024	49151224	231	9240										
KIAA1468	57614	broad.mit.edu	37	chr18	59925298	59925298	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtatcattatgggatacattGatgatccagacaaatatcat	7	6	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:59925298G>C	uc002lil.2	+	14	2229	c.2014G>C	c.(2014-2016)GAT>CAT	p.D672H	KIAA1468_uc002lik.1_Missense_Mutation_p.D672H|KIAA1468_uc010xel.1_Missense_Mutation_p.D672H|KIAA1468_uc002lim.2_Missense_Mutation_p.D316H	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	672	HEAT 2.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GGGATACATTGATGATCCAGA	0.313													0	0	0	0.038147	0	5	16										C	59925298	G	C	59925298	3	2	37	1	0	0	0	0	1	0	0	0	8236	1290	45	1	2068	1	KIAA1468	18	59925298	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	30999274	59925298	18151950	232	9241										
CDH7	1005	broad.mit.edu	37	chr18	63511079	63511079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgaagccaaaacaagttacaCgctacggatagaagctgcaa	9	9	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:63511079C>T	uc002ljz.2	+	7	1338	c.1013C>T	c.(1012-1014)ACG>ATG	p.T338M	CDH7_uc002lka.2_Missense_Mutation_p.T338M|CDH7_uc002lkb.2_Missense_Mutation_p.T338M	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	338	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ACAAGTTACACGCTACGGATA	0.418													0	0	0	0.069234	0	11	26										T	63511079	C	T	63511079	3	4	37	1	0	0	0	0	1	0	0	0	3115	536	19	2	1035	2	CDH7	18	63511079	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3585781	63511079	14566169	233	9242										
LMNB2	84823	broad.mit.edu	37	chr19	2438516	2438516	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggccaccgtaagctcgccctCcctcttcttggcgctgaaag	10	16	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:2438516C>T	uc002lvy.2	-	3	442	c.355G>A	c.(355-357)GAG>AAG	p.E119K	LMNB2_uc002lwa.1_Missense_Mutation_p.E139K	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	119	Rod.|Coil 1B.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTCGCCCTCCCTCTTCTTG	0.662													0	0	0	0.083992	0	21	13										T	2438516	C	T	2438516	3	4	37	1	0	0	0	0	1	0	0	0	8850	864	30	1	1487	1	LMNB2	19	2438516	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		2438516	56690467	234	9243										
PTPRS	5802	broad.mit.edu	37	chr19	5214591	5214591	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cccgtgacttctcctccagcCgcgtcatcatgacgatggtc	9	16	3	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:5214591C>T	uc002mbv.2	-	29	4709	c.4475G>A	c.(4474-4476)CGG>CAG	p.R1492Q	PTPRS_uc002mbu.1_Missense_Mutation_p.R1061Q|PTPRS_uc010xin.1_Missense_Mutation_p.R1034Q|PTPRS_uc002mbw.2_Missense_Mutation_p.R1454Q|PTPRS_uc002mbx.2_Missense_Mutation_p.R1049Q|PTPRS_uc002mby.2_Missense_Mutation_p.R1045Q	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1492	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CTCCTCCAGCCGCGTCATCAT	0.632													0	0	0	0.204396	0	19	55										T	5214591	C	T	5214591	3	4	37	1	0	0	0	0	1	0	0	0	12811	652	23	2	1411	2	PTPRS	19	5214591	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	2776075	5214591	53914392	235	9244										
PNPLA6	10908	broad.mit.edu	37	chr19	7625568	7625568	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtacgggaaggcggtgtttgGaggctggagccgtggcaacg	20	7	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:7625568G>A	uc010xjq.1	+	31	3959	c.3764G>A	c.(3763-3765)GGA>GAA	p.G1255E	PNPLA6_uc002mgq.1_Missense_Mutation_p.G1207E|PNPLA6_uc010xjp.1_Missense_Mutation_p.G1180E|PNPLA6_uc002mgr.1_Missense_Mutation_p.G1207E|PNPLA6_uc002mgs.2_Missense_Mutation_p.G1245E|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1246	Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						GCGGTGTTTGGAGGCTGGAGC	0.587													0	0	0	0.153744	0	27	20										A	7625568	G	A	7625568	3	1	37	1	0	0	0	0	1	0	0	0	12169	1174	41	1	3882	1	PNPLA6	19	7625568	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2410977	7625568	51503415	236	9245										
COL5A3	50509	broad.mit.edu	37	chr19	10073543	10073543	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagcctccaggcttttccttGgaccaggaggccaatttcac	9	14	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:10073543G>A	uc002mmq.1	-	65	4889	c.4803C>T	c.(4801-4803)TCC>TCT	p.S1601S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1601	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GCTTTTCCTTGGACCAGGAGG	0.532													0	0	0	0.09319	0	9	14										A	10073543	G	A	10073543	2	1	37	1	0	0	0	0	0	0	0	1	3698	1335	47	2		2	COL5A3	19	10073543	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2447975	10073543	49055440	237	9246										
SMARCA4	6597	broad.mit.edu	37	chr19	11136115	11136115	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagggcaaaggcggcaccaaGaccctgatgaacaccatcat	10	13	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:11136115G>C	uc002mqf.3	+	22	3383	c.3099G>C	c.(3097-3099)AAG>AAC	p.K1033N	SMARCA4_uc010dxp.2_Missense_Mutation_p.K1033N|SMARCA4_uc010dxo.2_Missense_Mutation_p.K1033N|SMARCA4_uc002mqg.1_Missense_Mutation_p.K1033N|SMARCA4_uc010dxq.2_Missense_Mutation_p.K1033N|SMARCA4_uc010dxr.2_Missense_Mutation_p.K1033N|SMARCA4_uc002mqj.3_Missense_Mutation_p.K1033N|SMARCA4_uc010dxs.2_Missense_Mutation_p.K1033N|SMARCA4_uc010dxt.1_Missense_Mutation_p.K253N|SMARCA4_uc002mqh.3_Missense_Mutation_p.K156N|SMARCA4_uc002mqi.1_Missense_Mutation_p.K236N	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1033					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCGGCACCAAGACCCTGATGA	0.632			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.214465	0	29	118										C	11136115	G	C	11136115	3	2	37	1	0	0	0	0	1	0	0	0	14770	933	33	1	3181	1	SMARCA4	19	11136115	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1062572	11136115	47992868	238	9247										
LPPR2	64748	broad.mit.edu	37	chr19	11473280	11473288	+	In_Frame_Del	DEL	GCGTGGTCC	GCGTGGTCC	-													0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtgcccggccttcctggtggGcgtggtccgcgtggccgagt							TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:11473280_11473288delGCGTGGTCC	uc002mre.1	+	7	1092_1100	c.755_763delGCGTGGTCC	c.(754-765)GGCGTGGTCCGC>GGC	p.VVR253del	LPPR2_uc002mrf.1_In_Frame_Del_p.VVR228del|LPPR2_uc010dxy.1_In_Frame_Del_p.VVR60del	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	253_255	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						TTCCTGGTGGGCGTGGTCCGCGTGGCCGA	0.651																		22	137	---	---								-	11473288	GCGTGGTCC	-	11473280	7	5	37	1	0	1	0	1	0	0	0	0	8925	1203	42	0	773	0	LPPR2	19	11473280	In_Frame_Del	DEL	GCGTGGTCC	TCGA-CU-A3KJ-01A-11D-A21A-08	337165	11473280	47655703	239	9248										
RFX1	5989	broad.mit.edu	37	chr19	14076445	14076445	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gccgagcactcactggggatGggccgcagcacgtcgggaat	16	12	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:14076445G>A	uc002mxv.2	-	15	2378	c.2106C>T	c.(2104-2106)CCC>CCT	p.P702P		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	702					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CACTGGGGATGGGCCGCAGCA	0.652													0	0	0	0.105934	0	12	43										A	14076445	G	A	14076445	2	1	37	1	0	0	0	0	0	0	0	1	13262	1335	47	2		2	RFX1	19	14076445	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2603165	14076445	45052538	240	9249										
JAK3	3718	broad.mit.edu	37	chr19	17948866	17948866	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaaggacccatggcccaggtTctcatgctgaatggtgaggg	15	9	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:17948866T>C	uc002nhn.3	-	12	1676	c.1576A>G	c.(1576-1578)AAC>GAC	p.N526D	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.N526D	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	526	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGGCCCAGGTTCTCATGCTGA	0.557		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.055883	0	18	44										C	17948866	T	C	17948866	3	2	37	1	0	0	0	0	1	0	0	0	7939	1783	62	5	1850	5	JAK3	19	17948866	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	3872421	17948866	41180117	241	9250										
HAPLN4	404037	broad.mit.edu	37	chr19	19369602	19369602	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtcctgctcggcgcacgcgcGctgcgcctccgcgaaggtca	14	17	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:19369602G>T	uc002nmb.2	-	4	602	c.547C>A	c.(547-549)CGC>AGC	p.R183S	HAPLN4_uc002nmc.2_Missense_Mutation_p.R183S	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	183	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			GCGCACGCGCGCTGCGCCTCC	0.706													1	0	1.02788e-11	0.160694	1.0806e-11	11	18										T	19369602	G	T	19369602	3	4	37	1	0	0	0	0	1	0	0	0	6957	1087	38	4	669	4	HAPLN4	19	19369602	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1420736	19369602	39759381	242	9251										
DPY19L3	147991	broad.mit.edu	37	chr19	32930745	32930745	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gtctgacatggcaatttaatCaatttatgatgctgatgcaa	8	6	2	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:32930745C>G	uc002ntg.2	+	8	960	c.784C>G	c.(784-786)CAA>GAA	p.Q262E	DPY19L3_uc002nth.1_Missense_Mutation_p.Q262E|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	262	Helical; (Potential).					integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					GCAATTTAATCAATTTATGAT	0.393													0	0	0	0.139131	0	44	48										G	32930745	C	G	32930745	3	3	37	1	0	0	0	0	1	0	0	0	4742	827	29	1	810	1	DPY19L3	19	32930745	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	13561143	32930745	26198238	243	9252										
APLP1	333	broad.mit.edu	37	chr19	36370075	36370075	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcctctccatgctgctcctgCgcaggaagaagccctacggg	11	15	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:36370075C>A	uc002oce.2	+	16	1948	c.1810C>A	c.(1810-1812)CGC>AGC	p.R604S	APLP1_uc010xsz.1_Missense_Mutation_p.R565S|APLP1_uc002ocf.2_Missense_Mutation_p.R605S|APLP1_uc002ocg.2_Missense_Mutation_p.R508S|APLP1_uc010xta.1_Missense_Mutation_p.R598S	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	604	Cytoplasmic (Potential).|Basolateral sorting signal (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCTGCTCCTGCGCAGGAAGAA	0.657													1	0	1.85244e-09	0.083992	1.91672e-09	23	107										A	36370075	C	A	36370075	3	1	37	1	0	0	0	0	1	0	0	0	778	768	27	4	1875	4	APLP1	19	36370075	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3439330	36370075	22758908	244	9253										
MEGF8	1954	broad.mit.edu	37	chr19	42880156	42880156	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccgtcggcagtgctggtggtCcgcggcgtgcgggaccggct	19	13	0	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:42880156C>T	uc002otl.3	+	41	8201	c.7566C>T	c.(7564-7566)GTC>GTT	p.V2522V	MEGF8_uc002otm.3_Silent_p.V2130V|MEGF8_uc002otn.3_Silent_p.V183V	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2589	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TGCTGGTGGTCCGCGGCGTGC	0.692													0	0	0	0.139131	0	87	149										T	42880156	C	T	42880156	2	4	37	1	0	0	0	0	0	0	0	1	9463	842	30	1		1	MEGF8	19	42880156	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	6510081	42880156	16248827	245	9254										
RSPH6A	81492	broad.mit.edu	37	chr19	46308019	46308019	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gccgtgcgcctccatgacctCgccaccttccgtcatctcct	7	20	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:46308019C>G	uc002pdm.2	-	3	1287	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	RSPH6A_uc002pdl.2_Missense_Mutation_p.E118Q	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	382	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						tccATGACCTCGCCACCTTCC	0.358													0	0	0	0.105934	0	12	20										G	46308019	C	G	46308019	3	3	37	1	0	0	0	0	1	0	0	0	13707	893	31	1	1025	1	RSPH6A	19	46308019	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3427863	46308019	12820964	246	9255										
LIG1	3978	broad.mit.edu	37	chr19	48634393	48634393	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ttgtcttcctgattcctgctGaagatcttcacctccccgcc	6	16	3	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:48634393G>A	uc002pia.1	-	19	1881	c.1761C>T	c.(1759-1761)TTC>TTT	p.F587F	LIG1_uc010xze.1_Silent_p.F280F|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Silent_p.F519F|LIG1_uc010xzg.1_Silent_p.F556F	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	587					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GATTCCTGCTGAAGATCTTCA	0.577								NER					0	0	0	0.047766	0	7	117										A	48634393	G	A	48634393	2	1	37	1	0	0	0	0	0	0	0	1	8781	1281	45	1		1	LIG1	19	48634393	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	2326374	48634393	10494590	247	9256										
DBP	1628	broad.mit.edu	37	chr19	49134232	49134232	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcccgcaccgatatctggttCtccttgagccgccgggcgtc	12	16	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:49134232C>G	uc002pjx.3	-	4	1228	c.840G>C	c.(838-840)GAG>GAC	p.E280D	DBP_uc002pjy.2_3'UTR	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	280					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		ATATCTGGTTCTCCTTGAGCC	0.652													0	0	0	0.163468	0	24	33										G	49134232	C	G	49134232	3	3	37	1	0	0	0	0	1	0	0	0	4256	912	32	1	141	1	DBP	19	49134232	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	499839	49134232	9994751	248	9257										
RASIP1	54922	broad.mit.edu	37	chr19	49224075	49224075	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcaaggagacgtggccacggGaggcccatggcgataattgg	16	9	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:49224075G>C	uc002pki.2	-	12	3069	c.2872C>G	c.(2872-2874)CCC>GCC	p.P958A	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Missense_Mutation_p.P219A	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	958					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GTGGCCACGGGAGGCCCATGG	0.602													0	0	0	0.139131	0	87	150										C	49224075	G	C	49224075	3	2	37	1	0	0	0	0	1	0	0	0	13078	1174	41	1	23	1	RASIP1	19	49224075	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	89843	49224075	9904908	249	9258										
AP2A1	160	broad.mit.edu	37	chr19	50302947	50302947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cctctacgccatgtgtgaccGgagcaatgccaagcagatcg	11	13	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:50302947G>A	uc002ppn.2	+	10	1407	c.1196G>A	c.(1195-1197)CGG>CAG	p.R399Q	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Missense_Mutation_p.R399Q|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	399					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ATGTGTGACCGGAGCAATGCC	0.592													0	0	0	0.139131	0	83	136										A	50302947	G	A	50302947	3	1	37	1	0	0	0	0	1	0	0	0	739	1116	39	2	1234	2	AP2A1	19	50302947	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1078872	50302947	8826036	250	9259										
ZNF761	388561	broad.mit.edu	37	chr19	53959831	53959831	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	catactggagagaaaccttaTaagtgtaatgagtgtggcaa	11	5	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:53959831T>C	uc010eqp.2	+	7	2528	c.2070T>C	c.(2068-2070)TAT>TAC	p.Y690Y	ZNF761_uc010ydy.1_Silent_p.Y636Y|ZNF761_uc002qbt.1_Silent_p.Y636Y	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	690	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AGAAACCTTATAAGTGTAATG	0.393													0	0	0	0.184627	0	5	75										C	53959831	T	C	53959831	2	2	37	1	0	0	0	0	0	0	0	1	18133	1413	49	5		5	ZNF761	19	53959831	Silent	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	3656884	53959831	5169152	251	9260										
TTYH1	57348	broad.mit.edu	37	chr19	54932494	54932494	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	atggcaacagtgagaccagtGatggggtgtcccagctcagc	14	10	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:54932494G>A	uc002qfq.2	+	3	441	c.349G>A	c.(349-351)GAT>AAT	p.D117N	TTYH1_uc010yey.1_Missense_Mutation_p.D166N|TTYH1_uc002qfr.2_Missense_Mutation_p.D117N|TTYH1_uc002qft.2_Missense_Mutation_p.D117N|TTYH1_uc002qfu.1_Missense_Mutation_p.D32N	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	117	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TGAGACCAGTGATGGGGTGTC	0.637													0	0	0	0.124865	0	36	164										A	54932494	G	A	54932494	3	1	37	1	0	0	0	0	1	0	0	0	16736	1290	45	1	359	1	TTYH1	19	54932494	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	972663	54932494	4196489	252	9261										
ZNF550	162972	broad.mit.edu	37	chr19	58058953	58058953	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	cagtgtgaaccctctgatgtCgaacgagataccacttcctg	9	12	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:58058953C>T	uc002qpe.1	-	2	536	c.536G>A	c.(535-537)CGA>CAA	p.R179Q	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	220	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCTCTGATGTCGAACGAGATA	0.483													0	0	0	0.139131	0	42	65										T	58058953	C	T	58058953	3	4	37	1	0	0	0	0	1	0	0	0	17979	884	31	1	613	1	ZNF550	19	58058953	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3126459	58058953	1070030	253	9262										
ZSCAN22	342945	broad.mit.edu	37	chr19	58846394	58846394	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acctccgagcgctgtgctgtCagtggctgcagcccgaggcg	15	14	1	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:58846394C>G	uc002qsc.2	+	2	373	c.226C>G	c.(226-228)CAG>GAG	p.Q76E	ZSCAN22_uc010yhz.1_Missense_Mutation_p.Q76E	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	76	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GCTGTGCTGTCAGTGGCTGCA	0.657													0	0	0	0.09319	0	11	128										G	58846394	C	G	58846394	3	3	37	1	0	0	0	0	1	0	0	0	18231	827	29	1	228	1	ZSCAN22	19	58846394	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	787441	58846394	282589	254	9263										
SFRS6	6431	broad.mit.edu	37	chr20	42088479	42088479	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acggaccacctgttcgtacaGaatacaggcttattgtagaa	9	9	0	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:42088479G>C	uc010zwg.1	+	3	495	c.325G>C	c.(325-327)GAA>CAA	p.E109Q	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.E109Q	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	109					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGTTCGTACAGAATACAGGCT	0.398													0	0	0	0.139131	0	45	66										C	42088479	G	C	42088479	3	2	37	1	0	0	0	0	1	0	0	0	14181	943	33	1	335	1	SFRS6	20	42088479	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		42088479	20937041	255	9264										
C20orf111	51526	broad.mit.edu	37	chr20	42825950	42825950	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acttccatatcatgccatctCttacactggcattccttgcc	4	15	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:42825950C>T	uc002xlk.2	-	4	758	c.621G>A	c.(619-621)AAG>AAA	p.K207K		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	207											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CATGCCATCTCTTACACTGGC	0.488													0	0	0	0.153744	0	23	60										T	42825950	C	T	42825950	2	4	37	1	0	0	0	0	0	0	0	1	2080	912	32	1		1	C20orf111	20	42825950	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	737471	42825950	20199570	256	9265										
NFATC2	4773	broad.mit.edu	37	chr20	50139887	50139887	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccatgatcacggcagagccaGccacaggggggtacccagcc	13	15	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:50139887G>C	uc002xwd.2	-	2	1113	c.893C>G	c.(892-894)GCT>GGT	p.A298G	NFATC2_uc002xwc.2_Missense_Mutation_p.A298G|NFATC2_uc010zyv.1_Missense_Mutation_p.A79G|NFATC2_uc010zyw.1_Missense_Mutation_p.A79G|NFATC2_uc010zyx.1_Missense_Mutation_p.A278G|NFATC2_uc010zyy.1_Missense_Mutation_p.A79G|NFATC2_uc010zyz.1_Missense_Mutation_p.A79G|NFATC2_uc002xwe.2_Missense_Mutation_p.A278G	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	298					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGCAGAGCCAGCCACAGGGGG	0.706													0	0	0	0.132662	0	13	20										C	50139887	G	C	50139887	3	2	37	1	0	0	0	0	1	0	0	0	10362	971	34	4	1968	4	NFATC2	20	50139887	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	7313937	50139887	12885633	257	9266										
MYT1	4661	broad.mit.edu	37	chr20	62871220	62871220	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tccggcctgagccaggccctCatccaaagtctcgccaatat	8	16	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:62871220C>T	uc002yii.2	+	22	3565	c.3201C>T	c.(3199-3201)CTC>CTT	p.L1067L	MYT1_uc002yij.2_Silent_p.L726L|MYT1_uc002yik.2_Silent_p.L33L	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1067					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCAGGCCCTCATCCAAAGTC	0.592													0	0	0	0.139131	0	40	260										T	62871220	C	T	62871220	2	4	37	1	0	0	0	0	0	0	0	1	10106	813	29	1		1	MYT1	20	62871220	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	12731333	62871220	154300	258	9267										
USP25	29761	broad.mit.edu	37	chr21	17250767	17250767	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gcccgaatcatgttgtccctCagtcgaactcctgctgatgg	10	13	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:17250767C>T	uc002yjy.1	+	24	3358	c.3141C>T	c.(3139-3141)CTC>CTT	p.L1047L	USP25_uc011aby.1_Silent_p.L1117L|USP25_uc002yjz.1_Silent_p.L1079L|USP25_uc010gla.1_Silent_p.L442L	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	1047					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TGTTGTCCCTCAGTCGAACTC	0.433													0	0	0	0.139131	0	32	35										T	17250767	C	T	17250767	2	4	37	1	0	0	0	0	0	0	0	1	17053	813	29	1		1	USP25	21	17250767	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08		17250767	30879128	259	9268										
TMPRSS3	64699	broad.mit.edu	37	chr21	43802184	43802184	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccagatgtaccattgaacgtGagtggcccggccagcttcat	11	12	1	3			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:43802184G>C	uc002zbb.2	-	9	1143	c.942C>G	c.(940-942)CTC>CTG	p.L314L	TMPRSS3_uc002zay.2_Silent_p.L72L|TMPRSS3_uc002zaz.2_Silent_p.L187L|TMPRSS3_uc002zba.2_Silent_p.L187L|TMPRSS3_uc002zbc.2_Silent_p.L314L|TMPRSS3_uc002zbd.2_Silent_p.L314L	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	314	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						CATTGAACGTGAGTGGCCCGG	0.373													0	0	0	0.139131	0	36	44										C	43802184	G	C	43802184	2	2	37	1	0	0	0	0	0	0	0	1	16245	1277	45	1		1	TMPRSS3	21	43802184	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	26551417	43802184	4327711	260	9269										
PWP2	5822	broad.mit.edu	37	chr21	45550606	45550606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgaagatgacagcctgcatCtgcttggaggaggaggcaga	15	8	1	4			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:45550606C>G	uc002zeb.2	+	21	2803	c.2713C>G	c.(2713-2715)CTG>GTG	p.L905V	C21orf33_uc002zec.3_5'Flank|C21orf33_uc002zed.3_5'Flank	NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	905						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CAGCCTGCATCTGCTTGGAGG	0.582													0	0	0	0.139131	0	53	60										G	45550606	C	G	45550606	3	3	37	1	0	0	0	0	1	0	0	0	12844	912	32	1	2795	1	PWP2	21	45550606	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	1748422	45550606	2579289	261	9270										
C21orf70	85395	broad.mit.edu	37	chr21	46363637	46363637	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	accaacatctttgccaggacCaagatagaccccagcgcctt	7	15	1	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:46363637C>A	uc002zgl.2	+	2	186	c.168C>A	c.(166-168)ACC>ACA	p.T56T	C21orf70_uc002zgm.2_Silent_p.T56T	NM_058190	NP_478070	Q9NSI2	CU070_HUMAN	hypothetical protein LOC85395	56											0				Colorectal(79;0.248)		TTGCCAGGACCAAGATAGACC	0.552													1	0	1.04352e-10	0.193644	1.09004e-10	29	69										A	46363637	C	A	46363637	2	1	37	1	0	0	0	0	0	0	0	1	2133	581	21	4		4	C21orf70	21	46363637	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	813031	46363637	1766258	262	9271										
PCNT	5116	broad.mit.edu	37	chr21	47786794	47786794	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ccagacatctgtccagccttGattctttggaatcctgttac	7	12	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:47786794G>C	uc002zji.3	+	15	3012	c.2905G>C	c.(2905-2907)GAT>CAT	p.D969H	PCNT_uc002zjj.2_Missense_Mutation_p.D851H	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	969					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTCCAGCCTTGATTCTTTGGA	0.562													0	0	0	0.134883	0	26	82										C	47786794	G	C	47786794	3	2	37	1	0	0	0	0	1	0	0	0	11590	1290	45	1	2963	1	PCNT	21	47786794	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	1423157	47786794	343101	263	9272										
CHEK2	11200	broad.mit.edu	37	chr22	29106036	29106036	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tctatttctgtttcaacattGagagctgggtcctttgataa	8	7	3	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:29106036G>A	uc003adu.1	-	7	876	c.804C>T	c.(802-804)CTC>CTT	p.L268L	CHEK2_uc003ads.1_Silent_p.L47L|CHEK2_uc010gvh.1_Silent_p.L177L|CHEK2_uc010gvi.1_Silent_p.L268L|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Silent_p.L311L|CHEK2_uc003adv.1_Silent_p.L268L|CHEK2_uc003adw.1_Silent_p.L268L|CHEK2_uc003adx.1_Silent_p.L47L|CHEK2_uc003ady.1_Silent_p.L268L|CHEK2_uc003adz.1_Silent_p.L72L	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	268	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TTTCAACATTGAGAGCTGGGT	0.264			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.058154	0	7	5										A	29106036	G	A	29106036	2	1	37	1	0	0	0	0	0	0	0	1	3335	1277	45	1		1	CHEK2	22	29106036	Silent	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		29106036	22198530	264	9273										
EIF3L	51386	broad.mit.edu	37	chr22	38266268	38266268	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcgttccaatcccaaaatctGgaatgttcatagtgtcctca	6	11	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:38266268G>A	uc003auf.2	+	8	752	c.665G>A	c.(664-666)TGG>TAG	p.W222*	EIF3L_uc003aue.1_Nonsense_Mutation_p.W222*|EIF3L_uc011ann.1_Nonsense_Mutation_p.W174*|EIF3L_uc003aug.2_Nonsense_Mutation_p.W114*|EIF3L_uc003auh.2_5'UTR	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	222						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						CCCAAAATCTGGAATGTTCAT	0.458													0	0	0	0.175082	0	16	25										A	38266268	G	A	38266268	4	1	37	1	0	0	0	0	0	1	0	0	5022	1357	47	2	695	2	EIF3L	22	38266268	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	9160232	38266268	13038298	265	9274										
EP300	2033	broad.mit.edu	37	chr22	41572404	41572404	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	acctggagttctcttcactcCgaagagcccagtggtccacc	9	15	2	1	rs139310551		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41572404C>T	uc003azl.3	+	30	5328	c.4933C>T	c.(4933-4935)CGA>TGA	p.R1645*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1645	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.R1645R(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTCTTCACTCCGAAGAGCCCA	0.557			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.080422	0	34	13										T	41572404	C	T	41572404	4	4	37	1	0	0	0	0	0	1	0	0	5148	644	23	2	5051	2	EP300	22	41572404	Nonsense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	3306136	41572404	9732162	266	9275			5	35		6	6	1486	C		3.153809e-12
EP300	2033	broad.mit.edu	37	chr22	41572932	41572932	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgagtatccagcgctgcatCcagtctctggtccatgcttg	10	13	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41572932C>G	uc003azl.3	+	31	5612	c.5217C>G	c.(5215-5217)ATC>ATG	p.I1739M		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1739	Binding region for E1A adenovirus.|TAZ-type 2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGCGCTGCATCCAGTCTCTGG	0.562			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.124865	0	37	16										G	41572932	C	G	41572932	3	3	37	1	0	0	0	0	1	0	0	0	5148	845	30	1	5339	1	EP300	22	41572932	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	528	41572932	9731634	267	9276			5	35		6	6	1486	C		3.153809e-12
EP300	2033	broad.mit.edu	37	chr22	41573079	41573079	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tgcaagcagctcattgccctCtgctgctaccatgccaagca	8	15	2	0	rs143551315	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573079C>G	uc003azl.3	+	31	5759	c.5364C>G	c.(5362-5364)CTC>CTG	p.L1788L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1788	Binding region for E1A adenovirus.|TAZ-type 2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TCATTGCCCTCTGCTGCTACC	0.572			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.139131	0	54	23										G	41573079	C	G	41573079	2	3	37	1	0	0	0	0	0	0	0	1	5148	900	32	1		1	EP300	22	41573079	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	147	41573079	9731487	268	9277			5	35		6	6	1486	C		3.153809e-12
EP300	2033	broad.mit.edu	37	chr22	41573719	41573719	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ggagccaaggaggattgcctCagccccagcaactacagtct	11	13	2	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573719C>G	uc003azl.3	+	31	6399	c.6004C>G	c.(6004-6006)CAG>GAG	p.Q2002E		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2002					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGGATTGCCTCAGCCCCAGCA	0.602			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.131918	0	37	17										G	41573719	C	G	41573719	3	3	37	1	0	0	0	0	1	0	0	0	5148	827	29	1	6126	1	EP300	22	41573719	Missense_Mutation	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	640	41573719	9730847	269	9278			5	35		6	6	1486	C		3.153809e-12
EP300	2033	broad.mit.edu	37	chr22	41573838	41573838	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caggtaggtatcagcccactCaaaccaggcactgtgtctca	9	13	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573838C>G	uc003azl.3	+	31	6518	c.6123C>G	c.(6121-6123)CTC>CTG	p.L2041L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2041	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TCAGCCCACTCAAACCAGGCA	0.547			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.139131	0	48	25										G	41573838	C	G	41573838	2	3	37	1	0	0	0	0	0	0	0	1	5148	813	29	1		1	EP300	22	41573838	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	119	41573838	9730728	270	9279			5	35		6	6	1486	C		3.153809e-12
EP300	2033	broad.mit.edu	37	chr22	41573889	41573889	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	caaaaccttttgcggactctCaggtctcccagctctcccct	6	17	3	0			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573889C>G	uc003azl.3	+	31	6569	c.6174C>G	c.(6172-6174)CTC>CTG	p.L2058L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2058	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGCGGACTCTCAGGTCTCCCA	0.552			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.139131	0	52	24										G	41573889	C	G	41573889	2	3	37	1	0	0	0	0	0	0	0	1	5148	813	29	1		1	EP300	22	41573889	Silent	SNP	C	TCGA-CU-A3KJ-01A-11D-A21A-08	51	41573889	9730677	271	9280			5	35		6	6	1486	C		3.153809e-12
MEI1	150365	broad.mit.edu	37	chr22	42112115	42112115	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tggcaagttggtggatgccaTccctgctctggcagacgagc	14	11	1	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:42112115T>C	uc003baz.1	+	5	519	c.494T>C	c.(493-495)ATC>ACC	p.I165T	MEI1_uc003bay.3_Missense_Mutation_p.I165T|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	165							binding			central_nervous_system(1)|skin(1)	2						GTGGATGCCATCCCTGCTCTG	0.517													0	0	0	0.160694	0	14	32										C	42112115	T	C	42112115	3	2	37	1	0	0	0	0	1	0	0	0	9465	1435	50	5	512	5	MEI1	22	42112115	Missense_Mutation	SNP	T	TCGA-CU-A3KJ-01A-11D-A21A-08	538226	42112115	9192451	272	9281										
ZNF645	158506	broad.mit.edu	37	chrX	22291896	22291896	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	tcccgactattatcctgagtGtcaaagtcaaccagcggtat	8	11	2	1			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:22291896G>A	uc004dai.1	+	1	837	c.788G>A	c.(787-789)TGT>TAT	p.C263Y		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	263	Pro-rich.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						TATCCTGAGTGTCAAAGTCAA	0.413													0	0	0	0.139131	0	55	70										A	22291896	G	A	22291896	3	1	37	1	0	0	0	0	1	0	0	0	18058	1377	48	2	790	2	ZNF645	23	22291896	Missense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08		22291896	132978664	273	9282										
KDM6A	7403	broad.mit.edu	37	chrX	44949017	44949017	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	gaatttcctaatgggttcttGgtggcccaatcttgaagatc	10	8	2	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:44949017G>A	uc004dge.3	+	25	3953	c.3578G>A	c.(3577-3579)TGG>TAG	p.W1193*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.W1245*|KDM6A_uc011mla.1_Nonsense_Mutation_p.W1148*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.W1200*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.W897*|KDM6A_uc011mld.1_Nonsense_Mutation_p.W832*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1193	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						ATGGGTTCTTGGTGGCCCAAT	0.353			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.069234	0	9	1										A	44949017	G	A	44949017	4	1	37	1	0	0	0	0	0	1	0	0	8137	1357	47	2	3676	2	KDM6A	23	44949017	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	22657121	44949017	110321543	274	9283										
HUWE1	10075	broad.mit.edu	37	chrX	53620499	53620499	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.454212454212454	124	1.95482644360811e-45	4.01273701969862	5.4333753678016	3.0215939861384	0.106311089229088	0.222910348383572	93	ctgtgccatcaggcaagtctGagtgttccaatccctcagaa	9	12	3	2			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:53620499G>C	uc004dsp.2	-	32	3968	c.3566C>G	c.(3565-3567)TCA>TGA	p.S1189*	HUWE1_uc004dsn.2_Nonsense_Mutation_p.S14*	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1189					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGGCAAGTCTGAGTGTTCCAA	0.453													0	0	0	0.189662	0	18	25										C	53620499	G	C	53620499	4	2	37	1	0	0	0	0	0	1	0	0	7461	1294	45	1	9770	1	HUWE1	23	53620499	Nonsense_Mutation	SNP	G	TCGA-CU-A3KJ-01A-11D-A21A-08	8671482	53620499	101650061	275	9284										
VWA1	64856	broad.mit.edu	37	chr1	1372365	1372365	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctgctggacagctcagccagCgtctctcactacgagttctc	9	15	4	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:1372365C>T	uc001afs.2	+	2	352	c.132C>T	c.(130-132)AGC>AGT	p.S44S	VWA1_uc001afr.2_Intron	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	44	VWFA.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCTCAGCCAGCGTCTCTCACT	0.672													0	0	0	0.279185	0	43	42										T	1372365	C	T	1372365	2	4	38	1	0	0	0	0	0	0	0	1	17235	767	27	2		2	VWA1	1	1372365	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		1372365	247878256	1	9285										
VPS13D	55187	broad.mit.edu	37	chr1	12336628	12336628	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tgaagaggccttatgatgctGaagtctccctaactgttcat	9	9	2	4			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:12336628G>T	uc001atv.2	+	19	3124	c.2983G>T	c.(2983-2985)GAA>TAA	p.E995*	VPS13D_uc001atw.2_Nonsense_Mutation_p.E995*|VPS13D_uc001atx.2_Nonsense_Mutation_p.E183*	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	995					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTATGATGCTGAAGTCTCCCT	0.453											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.20344e-50	0.139131	2.47488e-50	107	69										T	12336628	G	T	12336628	4	4	38	1	0	0	0	0	0	1	0	0	17189	1291	45	3	3053	3	VPS13D	1	12336628	Nonsense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	10964263	12336628	236913993	2	9286										
PRAMEF2	65122	broad.mit.edu	37	chr1	12918913	12918913	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tggagctggcggggcagagcCtgctgagagaccaggccttg	18	10	0	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:12918913C>T	uc001aum.1	+	2	136	c.49C>T	c.(49-51)CTG>TTG	p.L17L		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	17											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGGCAGAGCCTGCTGAGAGA	0.562													0	0	0	0.139131	0	106	77										T	12918913	C	T	12918913	2	4	38	1	0	0	0	0	0	0	0	1	12435	680	24	2		2	PRAMEF2	1	12918913	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	582285	12918913	236331708	3	9287										
ZMYM4	9202	broad.mit.edu	37	chr1	35853067	35853067	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctttgcagggcaaaatgtttCagttctgtggcaagaattgt	11	6	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:35853067C>T	uc001byt.2	+	13	2205	c.2125C>T	c.(2125-2127)CAG>TAG	p.Q709*	ZMYM4_uc009vuu.2_Nonsense_Mutation_p.Q677*|ZMYM4_uc001byu.2_Nonsense_Mutation_p.Q385*|ZMYM4_uc009vuv.2_Nonsense_Mutation_p.Q448*	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	709	MYM-type 7.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAAAATGTTTCAGTTCTGTGG	0.294													0	0	0	0.183431	0	34	70										T	35853067	C	T	35853067	4	4	38	1	0	0	0	0	0	1	0	0	17699	827	29	1	2175	1	ZMYM4	1	35853067	Nonsense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	22934154	35853067	213397554	4	9288										
PGM1	5236	broad.mit.edu	37	chr1	64114205	64114205	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	caggttctgaccacatccgtGagaaagatggactgtgggct	13	9	1	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:64114205G>A	uc001dbh.2	+	8	1375	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	PGM1_uc010ooy.1_Missense_Mutation_p.E191K|PGM1_uc010ooz.1_Missense_Mutation_p.E406K	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	388					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						CCACATCCGTGAGAAAGATGG	0.478													0	0	0	0.069234	0	10	24										A	64114205	G	A	64114205	3	1	38	1	0	0	0	0	1	0	0	0	11797	1291	45	1	1496	1	PGM1	1	64114205	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	28261138	64114205	185136416	5	9289										
IL23R	149233	broad.mit.edu	37	chr1	67672625	67672625	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cagccgtcatttccagggctGagactataaatgctacagtg	10	10	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:67672625G>A	uc001ddo.2	+	6	770	c.685G>A	c.(685-687)GAG>AAG	p.E229K	IL23R_uc009waz.2_Missense_Mutation_p.E26K|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_5'UTR|IL23R_uc010opk.1_Missense_Mutation_p.E186K|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_5'UTR|IL23R_uc010opn.1_Missense_Mutation_p.E74K|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Missense_Mutation_p.E88K|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Missense_Mutation_p.E88K|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_Missense_Mutation_p.E26K|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_Intron|IL23R_uc010opv.1_Intron|IL23R_uc010opw.1_5'UTR|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_Missense_Mutation_p.E26K|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_Intron|IL23R_uc010oqb.1_Missense_Mutation_p.E88K|IL23R_uc010oqc.1_5'UTR|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_5'UTR|IL23R_uc010oqf.1_5'UTR|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron|IL23R_uc001dds.2_5'Flank|IL23R_uc001ddt.2_5'Flank	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	229	Extracellular (Potential).|Fibronectin type-III 2.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						TTCCAGGGCTGAGACTATAAA	0.373													0	0	0	0.160694	0	18	8										A	67672625	G	A	67672625	3	1	38	1	0	0	0	0	1	0	0	0	7676	1291	45	1	703	1	IL23R	1	67672625	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	3558420	67672625	181577996	6	9290										
FPGT	8790	broad.mit.edu	37	chr1	74670283	74670283	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tttgagtttattaggtttgaCaaacctggctttactgcttt	8	6	0	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:74670283C>A	uc001dgb.1	+	4	589	c.552C>A	c.(550-552)GAC>GAA	p.D184E	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	184					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TTAGGTTTGACAAACCTGGCT	0.348													1	0	1.06961e-07	0.27861	1.11268e-07	8	59										A	74670283	C	A	74670283	3	1	38	1	0	0	0	0	1	0	0	0	6037	477	17	4	566	4	FPGT	1	74670283	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	6997658	74670283	174580338	7	9291										
RPAP2	79871	broad.mit.edu	37	chr1	92789860	92789860	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gaaactgaaaagttaaatctGaggatcagggagttttacag	11	4	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:92789860G>C	uc001dot.2	+	8	1492	c.1383G>C	c.(1381-1383)CTG>CTC	p.L461L	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	461						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		AGTTAAATCTGAGGATCAGGG	0.403													0	0	0	0.189662	0	20	58										C	92789860	G	C	92789860	2	2	38	1	0	0	0	0	0	0	0	1	13542	1277	45	1		1	RPAP2	1	92789860	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	18119577	92789860	156460761	8	9292										
CRTC2	200186	broad.mit.edu	37	chr1	153930832	153930832	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gcccctcacccgggtggagcCgatgtccatcatcacctcct	9	18	3	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:153930832C>A	uc010ped.1	-	1	212	c.142G>T	c.(142-144)GGC>TGC	p.G48C		NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	48					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CGGGTGGAGCCGATGTCCATC	0.572													1	0	4.7546e-09	0.146539	5.0477e-09	14	20										A	153930832	C	A	153930832	3	1	38	1	0	0	0	0	1	0	0	0	3900	652	23	4	1995	4	CRTC2	1	153930832	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	61140972	153930832	95319789	9	9293										
NUF2	83540	broad.mit.edu	37	chr1	163317648	163317648	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaaagactgatgattgtgaaGaaggaaaaacttgccacagc	10	6	0	5			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:163317648G>A	uc001gcq.1	+	12	1344	c.1044G>A	c.(1042-1044)AAG>AAA	p.K348K	NUF2_uc001gcr.1_Silent_p.K348K|NUF2_uc009wvc.1_Silent_p.K301K	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	348	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					TGATTGTGAAGAAGGAAAAAC	0.353													0	0	0	0.058154	0	9	45										A	163317648	G	A	163317648	2	1	38	1	0	0	0	0	0	0	0	1	10747	933	33	1		1	NUF2	1	163317648	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	9386816	163317648	85932973	10	9294										
POU2F1	5451	broad.mit.edu	37	chr1	167365587	167365587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cagccaaactaccatctctcGatttgaagccttgaacctca	5	14	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:167365587G>A	uc001gec.2	+	11	1145	c.983G>A	c.(982-984)CGA>CAA	p.R328Q	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Missense_Mutation_p.R326Q|POU2F1_uc001gee.2_Missense_Mutation_p.R328Q|POU2F1_uc010plh.1_Missense_Mutation_p.R265Q|POU2F1_uc001gef.2_Missense_Mutation_p.R340Q|POU2F1_uc001geg.2_Missense_Mutation_p.R226Q|POU2F1_uc009wvg.1_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	328	POU-specific.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						ACCATCTCTCGATTTGAAGCC	0.428													0	0	0	0.139131	0	124	13										A	167365587	G	A	167365587	3	1	38	1	0	0	0	0	1	0	0	0	12271	1058	37	1	1017	1	POU2F1	1	167365587	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	4047939	167365587	81885034	11	9295										
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200819069	200819069	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aacagcgtggacataatccaGaagaaaaggaaatcaaacct	8	8	1	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:200819069G>A	uc001gvl.2	+	12	3475	c.3205G>A	c.(3205-3207)GAA>AAA	p.E1069K	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.E1058K|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.E1042K	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1069						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ACATAATCCAGAAGAAAAGGA	0.413													0	0	0	0.279207	0	25	67										A	200819069	G	A	200819069	3	1	38	1	0	0	0	0	1	0	0	0	2612	943	33	1	3214	1	CAMSAP1L1	1	200819069	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	33453482	200819069	48431552	12	9296										
ACTA1	58	broad.mit.edu	37	chr1	229567907	229567907	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	acgtagcacagcttctccttGatgtcgcgcacgatctcgcg	10	14	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:229567907G>C	uc001htm.2	-	5	747	c.642C>G	c.(640-642)ATC>ATG	p.I214M		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	214					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GCTTCTCCTTGATGTCGCGCA	0.517													0	0	0	0.160694	0	16	12										C	229567907	G	C	229567907	3	2	38	1	0	0	0	0	1	0	0	0	191	1280	45	1	503	1	ACTA1	1	229567907	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	28748838	229567907	19682714	13	9297										
ARID4B	51742	broad.mit.edu	37	chr1	235403707	235403707	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctttgcctagtagctcatcaAtctgtttcctatcatcctca	4	13	5	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:235403707A>G	uc001hwq.2	-	8	1004	c.506T>C	c.(505-507)ATT>ACT	p.I169T	ARID4B_uc001hwr.2_Missense_Mutation_p.I169T|ARID4B_uc001hws.3_Missense_Mutation_p.I169T|ARID4B_uc001hwu.1_Missense_Mutation_p.I169T|ARID4B_uc001hwt.3_5'UTR	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TAGCTCATCAATCTGTTTCCT	0.373													0	0	0	0.225048	0	38	4										G	235403707	A	G	235403707	3	3	38	1	0	0	0	0	1	0	0	0	920	101	4	5	3500	5	ARID4B	1	235403707	Missense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	5835800	235403707	13846914	14	9298										
OR2T11	127077	broad.mit.edu	37	chr1	248789671	248789671	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tggggcagcacgtatgtgtaGaaggcagccccatagaagat	14	8	0	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:248789671G>C	uc001ier.1	-	1	759	c.759C>G	c.(757-759)TTC>TTG	p.F253L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGTATGTGTAGAAGGCAGCCC	0.522													0	0	0	0.09319	0	13	51										C	248789671	G	C	248789671	3	2	38	1	0	0	0	0	1	0	0	0	11018	933	33	1	195	1	OR2T11	1	248789671	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	13385964	248789671	460950	15	9299										
SH3BP5L	80851	broad.mit.edu	37	chr1	249119080	249119080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atcctctacaacttcaggccGcagctccccctgtggggtct	9	16	3	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr1:249119080G>A	uc001iew.1	-	2	607	c.55C>T	c.(55-57)CGG>TGG	p.R19W	SH3BP5L_uc001iev.1_5'UTR|hsa-mir-3124|MI0014140_5'Flank	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	19											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			ACTTCAGGCCGCAGCTCCCCC	0.607													0	0	0	0.139131	0	91	39										A	249119080	G	A	249119080	3	1	38	1	0	0	0	0	1	0	0	0	14248	1086	38	2	1150	2	SH3BP5L	1	249119080	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	329409	249119080	131541	16	9300										
TPO	7173	broad.mit.edu	37	chr2	1437377	1437377	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcaacaatcacagcatccaaCgggtaatgtgtgcccctctc	7	14	3	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:1437377C>T	uc002qww.2	+	4	438	c.347C>T	c.(346-348)ACG>ATG	p.T116M	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Missense_Mutation_p.T116M|TPO_uc002qwu.2_Missense_Mutation_p.T116M|TPO_uc002qwr.2_Missense_Mutation_p.T116M|TPO_uc002qwx.2_Missense_Mutation_p.T116M|TPO_uc010yio.1_Missense_Mutation_p.T116M|TPO_uc010yip.1_Missense_Mutation_p.T116M	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	116	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAGCATCCAACGGGTAATGTG	0.498													0	0	0	0.27861	0	8	5										T	1437377	C	T	1437377	3	4	38	1	0	0	0	0	1	0	0	0	16407	536	19	2	357	2	TPO	2	1437377	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		1437377	241761996	17	9301										
CCT7	10574	broad.mit.edu	37	chr2	73466864	73466864	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gtgcctgccaggtgattgctGaggctgtaagaactaccctg	13	10	0	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:73466864G>A	uc002siz.2	+	2	202	c.100G>A	c.(100-102)GAG>AAG	p.E34K	CCT7_uc002sja.2_Intron|CCT7_uc010yrf.1_5'UTR|CCT7_uc010feu.2_Missense_Mutation_p.E34K|CCT7_uc010yrg.1_5'UTR|CCT7_uc010yrh.1_5'UTR|CCT7_uc010yri.1_Intron	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	34					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						GGTGATTGCTGAGGCTGTAAG	0.522													0	0	0	0.105934	0	14	13										A	73466864	G	A	73466864	3	1	38	1	0	0	0	0	1	0	0	0	2959	1291	45	1	106	1	CCT7	2	73466864	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	72029487	73466864	169732509	18	9302										
IL18R1	8809	broad.mit.edu	37	chr2	103013262	103013262	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tataactcaaggttctggaaGaaccttctttacttaatgcc	6	9	3	1	rs138611669		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:103013262G>A	uc002tbw.3	+	11	1692	c.1542G>A	c.(1540-1542)AAG>AAA	p.K514K	IL18R1_uc010ywc.1_Silent_p.K513K|IL18R1_uc010ywd.1_Silent_p.K358K|IL18R1_uc010fiy.2_Silent_p.K514K	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	514	TIR.|Cytoplasmic (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						GGTTCTGGAAGAACCTTCTTT	0.413													0	0	0	0.125774	0	29	52										A	103013262	G	A	103013262	2	1	38	1	0	0	0	0	0	0	0	1	7647	933	33	1		1	IL18R1	2	103013262	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	29546398	103013262	140186111	19	9303										
MFSD9	84804	broad.mit.edu	37	chr2	103343352	103343352	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaacacattggtggctgctcCgagaaggagatagcccagag	13	9	0	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:103343352C>G	uc002tcb.2	-	4	447	c.379G>C	c.(379-381)GGA>CGA	p.G127R	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	127	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						GTGGCTGCTCCGAGAAGGAGA	0.483													0	0	0	0.26419	0	25	22										G	103343352	C	G	103343352	3	3	38	1	0	0	0	0	1	0	0	0	9539	661	23	4	1057	4	MFSD9	2	103343352	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	330090	103343352	139856021	20	9304										
RGPD3	653489	broad.mit.edu	37	chr2	107084739	107084739	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tccccgtaggccttgctgcaActcatcgcgccaccaacctg	8	18	1	0	rs6718521	by1000genomes	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:107084739A>G	uc010ywi.1	-	1	63	c.6T>C	c.(4-6)AGT>AGC	p.S2S		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	2					intracellular transport		binding			ovary(1)	1						CCTTGCTGCAACTCATCGCGC	0.657													0	0	0	0.115264	0	2	4										G	107084739	A	G	107084739	2	3	38	1	0	0	0	0	0	0	0	1	13287	40	2	5		5	RGPD3	2	107084739	Silent	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	3741387	107084739	136114634	21	9305										
GULP1	51454	broad.mit.edu	37	chr2	189449086	189449086	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gtcttcgatgcctactcgcaAtggcacacagccacctccag	8	16	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:189449086A>G	uc010fru.2	+	10	1165	c.704A>G	c.(703-705)AAT>AGT	p.N235S	GULP1_uc002uqd.2_Missense_Mutation_p.N235S|GULP1_uc010zfw.1_Missense_Mutation_p.N132S|GULP1_uc002uqf.2_Missense_Mutation_p.N235S|GULP1_uc002uqg.2_Missense_Mutation_p.N235S|GULP1_uc002uqh.1_Missense_Mutation_p.N55S	NM_016315	NP_057399	Q9UBP9	GULP1_HUMAN	GULP, engulfment adaptor PTB domain containing	235					apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)			CCTACTCGCAATGGCACACAG	0.408													0	0	0	0.249174	0	22	72										G	189449086	A	G	189449086	3	3	38	1	0	0	0	0	1	0	0	0	6901	101	4	5	734	5	GULP1	2	189449086	Missense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	82364347	189449086	53750287	22	9306										
FN1	2335	broad.mit.edu	37	chr2	216249686	216249686	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gcaacaacttccaggtccctCggaacatcagaaactagaaa	7	12	1	2	rs142628915		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:216249686C>T	uc002vfa.2	-	29	4892	c.4626G>A	c.(4624-4626)CCG>CCA	p.P1542P	FN1_uc002vfb.2_Silent_p.P1451P|FN1_uc002vfc.2_Silent_p.P1451P|FN1_uc002vfd.2_Silent_p.P1542P|FN1_uc002vfe.2_Silent_p.P1451P|FN1_uc002vff.2_Silent_p.P1451P|FN1_uc002vfg.2_Silent_p.P1451P|FN1_uc002vfh.2_Silent_p.P1451P|FN1_uc002vfi.2_Silent_p.P1542P|FN1_uc002vfj.2_Silent_p.P1542P|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Silent_p.P169P|FN1_uc010fvc.1_5'Flank|FN1_uc010fvd.1_5'Flank	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1545	Fibronectin type-III 11.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAGGTCCCTCGGAACATCAG	0.418													0	0	0	0.080935	0	11	8										T	216249686	C	T	216249686	2	4	38	1	0	0	0	0	0	0	0	1	5962	871	31	1		1	FN1	2	216249686	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	26800600	216249686	26949687	23	9307										
FARP2	9855	broad.mit.edu	37	chr2	242415381	242415381	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cgggacctggtgggcatagaGaacctcattgctcctggcag	14	11	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr2:242415381G>A	uc002wbi.1	+	19	2358	c.2241G>A	c.(2239-2241)GAG>GAA	p.E747E	hsa-mir-3133|MI0014153_5'Flank	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	747					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TGGGCATAGAGAACCTCATTG	0.448													0	0	0	0.217242	0	5	1										A	242415381	G	A	242415381	2	1	38	1	0	0	0	0	0	0	0	1	5677	933	33	1		1	FARP2	2	242415381	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	26165695	242415381	783992	24	9308										
DAZL	1618	broad.mit.edu	37	chr3	16636050	16636050	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ttcactttaccggaggtacaAcatagctcctttgctcccca	6	14	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:16636050A>G	uc003cbb.2	-	8	905	c.611T>C	c.(610-612)GTT>GCT	p.V204A	DAZL_uc003cba.2_Missense_Mutation_p.V224A	NM_001351	NP_001342	Q92904	DAZL_HUMAN	deleted in azoospermia-like	204					germ cell development|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding|translation activator activity				0						CGGAGGTACAACATAGCTCCT	0.299													0	0	0	0.058154	0	10	10										G	16636050	A	G	16636050	3	3	38	1	0	0	0	0	1	0	0	0	4246	43	2	5	292	5	DAZL	3	16636050	Missense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08		16636050	181386380	25	9309										
KCNH8	131096	broad.mit.edu	37	chr3	19384094	19384094	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cccagacaaagtcaaaggaaGatcaagagcagggacccact	10	11	2	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:19384094G>T	uc003cbk.1	+	4	653	c.458G>T	c.(457-459)AGA>ATA	p.R153I	KCNH8_uc011awe.1_Missense_Mutation_p.R153I|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	153	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GTCAAAGGAAGATCAAGAGCA	0.448													1	0	2.79863e-10	0.099896	2.99164e-10	26	33										T	19384094	G	T	19384094	3	4	38	1	0	0	0	0	1	0	0	0	8038	942	33	3	472	3	KCNH8	3	19384094	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	2748044	19384094	178638336	26	9310										
CCR4	1233	broad.mit.edu	37	chr3	32995542	32995542	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccctggaaatcaacattctcGgattggtgatccccttaggg	10	11	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:32995542G>A	uc003cfg.1	+	2	796	c.628G>A	c.(628-630)GGA>AGA	p.G210R		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	210	Helical; Name=5; (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						CAACATTCTCGGATTGGTGAT	0.458													0	0	0	0.139131	0	51	68										A	32995542	G	A	32995542	3	1	38	1	0	0	0	0	1	0	0	0	2943	1117	39	2	630	2	CCR4	3	32995542	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	13611448	32995542	165026888	27	9311										
BSN	8927	broad.mit.edu	37	chr3	49692105	49692105	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccctggatccaatcccaggaCggcagtcgaccgccgtgcag	12	16	0	0	rs141249428	byFrequency	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:49692105C>T	uc003cxe.3	+	5	5230	c.5116C>T	c.(5116-5118)CGG>TGG	p.R1706W		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1706					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AATCCCAGGACGGCAGTCGAC	0.587													0	0	0	0.246493	0	42	72										T	49692105	C	T	49692105	3	4	38	1	0	0	0	0	1	0	0	0	1530	527	19	2	5134	2	BSN	3	49692105	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	16696563	49692105	148330325	28	9312										
ITIH1	3697	broad.mit.edu	37	chr3	52813598	52813598	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gtcaagcccaagcagctggtGcatcattttgaggtagatca	11	9	3	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:52813598G>A	uc003dfs.2	+	5	585	c.561G>A	c.(559-561)GTG>GTA	p.V187V	ITIH1_uc010hmn.1_RNA	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	187					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AGCAGCTGGTGCATCATTTTG	0.532													0	0	0	0.235728	0	38	31										A	52813598	G	A	52813598	2	1	38	1	0	0	0	0	0	0	0	1	7903	1306	46	2		2	ITIH1	3	52813598	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	3121493	52813598	145208832	29	9313										
SLMAP	7871	broad.mit.edu	37	chr3	57850350	57850350	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aattacaacataaaatagatGaaatggaagaaaaagaacag	7	3	0	4	rs138089766		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:57850350G>T	uc003dje.1	+	10	1247	c.1042G>T	c.(1042-1044)GAA>TAA	p.E348*	SLMAP_uc003djc.1_Nonsense_Mutation_p.E348*|SLMAP_uc003djd.1_Nonsense_Mutation_p.E348*|SLMAP_uc003djf.1_Nonsense_Mutation_p.E348*|SLMAP_uc003djg.1_5'UTR	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	348	Potential.|Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		TAAAATAGATGAAATGGAAGA	0.353													1	0	1.32136e-16	0.268233	1.43224e-16	44	51										T	57850350	G	T	57850350	4	4	38	1	0	0	0	0	0	1	0	0	14749	1291	45	3	1080	3	SLMAP	3	57850350	Nonsense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	5036752	57850350	140172080	30	9314										
PLXND1	23129	broad.mit.edu	37	chr3	129324823	129324823	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aggctgcggttgcgcgggaaGaaggagctgccgtaaccggt	18	9	0	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:129324823G>A	uc003emx.2	-	1	760	c.660C>T	c.(658-660)TTC>TTT	p.F220F		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	220	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGCGCGGGAAGAAGGAGCTGC	0.607													0	0	0	0.09319	0	12	16										A	129324823	G	A	129324823	2	1	38	1	0	0	0	0	0	0	0	1	12127	933	33	1		1	PLXND1	3	129324823	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	71474473	129324823	68697607	31	9315										
KLHL24	54800	broad.mit.edu	37	chr3	183368873	183368873	+	Silent	SNP	G	G	C													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gtctatcgtgccgttgatctGagaagaccactgttacacga							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:183368873G>C	uc003flv.2	+	3	1024	c.729G>C	c.(727-729)CTG>CTC	p.L243L	KLHL24_uc003flw.2_Silent_p.L243L|KLHL24_uc003flx.2_Silent_p.L243L	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	243	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			CCGTTGATCTGAGAAGACCAC	0.423													0	0	0	0.116897	0	30	38										C	183368873	G	C	183368873	2	2	38	1	0	0	0	0	0	0	0	1	8379	1277	45	1		1	KLHL24	3	183368873	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	54044050	183368873	14653557	32	9316	46	2								
KLHL24	54800	broad.mit.edu	37	chr3	183368878	183368878	+	Missense_Mutation	SNP	G	G	A													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcgtgccgttgatctgagaaGaccactgttacacgagctcc							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:183368878G>A	uc003flv.2	+	3	1029	c.734G>A	c.(733-735)AGA>AAA	p.R245K	KLHL24_uc003flw.2_Missense_Mutation_p.R245K|KLHL24_uc003flx.2_Missense_Mutation_p.R245K	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	245	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GATCTGAGAAGACCACTGTTA	0.423													0	0	0	0.294199	0	27	35										A	183368878	G	A	183368878	3	1	38	1	0	0	0	0	1	0	0	0	8379	942	33	1	736	1	KLHL24	3	183368878	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	5	183368878	14653552	33	9317	46	2								
KLHL24	54800	broad.mit.edu	37	chr3	183369003	183369003	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	agtgttatcagttgttgcatGaagcaagacggtaccacata	10	7	1	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr3:183369003G>A	uc003flv.2	+	3	1154	c.859G>A	c.(859-861)GAA>AAA	p.E287K	KLHL24_uc003flw.2_Missense_Mutation_p.E287K|KLHL24_uc003flx.2_Missense_Mutation_p.E287K	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	287						axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GTTGTTGCATGAAGCAAGACG	0.418													0	0	0	0.249174	0	19	24										A	183369003	G	A	183369003	3	1	38	1	0	0	0	0	1	0	0	0	8379	1291	45	1	861	1	KLHL24	3	183369003	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	125	183369003	14653427	34	9318										
ARAP2	116984	broad.mit.edu	37	chr4	36130168	36130168	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atattacctaaagcagagatCcaatatgggtagagctcctt	8	8	0	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:36130168C>T	uc003gsq.1	-	21	3965	c.3627G>A	c.(3625-3627)TGG>TGA	p.W1209*		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1209	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAGCAGAGATCCAATATGGGT	0.318													0	0	0	0.234183	0	22	37										T	36130168	C	T	36130168	4	4	38	1	0	0	0	0	0	1	0	0	839	856	30	1	1539	1	ARAP2	4	36130168	Nonsense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		36130168	155024108	35	9319										
WDR19	57728	broad.mit.edu	37	chr4	39233498	39233498	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gccagagcttgtctacatcaCatggaagtggagtttgcaat	11	8	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:39233498C>T	uc003gtv.2	+	18	2218	c.2064C>T	c.(2062-2064)CAC>CAT	p.H688H	WDR19_uc011byi.1_Silent_p.H528H|WDR19_uc003gtw.1_Silent_p.H285H	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	688					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						GTCTACATCACATGGAAGTGG	0.413													0	0	0	0.125774	0	29	48										T	39233498	C	T	39233498	2	4	38	1	0	0	0	0	0	0	0	1	17276	477	17	2		2	WDR19	4	39233498	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	3103330	39233498	151920778	36	9320										
COX7B2	170712	broad.mit.edu	37	chr4	46737171	46737171	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tgcagaatgctttgaatcttGagactgcttagtgcatttct	9	7	2	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:46737171G>A	uc003gxf.2	-	3	219	c.39C>T	c.(37-39)CTC>CTT	p.L13L	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	13						integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						TTTGAATCTTGAGACTGCTTA	0.423													0	0	0	0.203993	0	38	61										A	46737171	G	A	46737171	2	1	38	1	0	0	0	0	0	0	0	1	3783	1277	45	1		1	COX7B2	4	46737171	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	7503673	46737171	144417105	37	9321										
FRYL	285527	broad.mit.edu	37	chr4	48549632	48549632	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	taatctaagtgtgcaacttgTttgactgtaagcaccctggg	10	8	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:48549632T>A	uc003gyh.1	-	41	5648	c.5043A>T	c.(5041-5043)AAA>AAT	p.K1681N	FRYL_uc003gyg.1_Missense_Mutation_p.K377N|FRYL_uc003gyi.1_Missense_Mutation_p.K570N|FRYL_uc003gyj.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1681					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GTGCAACTTGTTTGACTGTAA	0.343													0	0	0	0.134883	0	28	21										A	48549632	T	A	48549632	3	1	38	1	0	0	0	0	1	0	0	0	6064	1722	60	5	4094	5	FRYL	4	48549632	Missense_Mutation	SNP	T	TCGA-CU-A3QU-01A-11D-A22Z-08	1812461	48549632	142604644	38	9322										
RXFP1	59350	broad.mit.edu	37	chr4	159547979	159547979	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ttttatgttccagggaccttGaaggcaaccatatccataat	7	9	0	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr4:159547979G>C	uc003ipz.2	+	10	845	c.763G>C	c.(763-765)GAA>CAA	p.E255Q	RXFP1_uc010iqj.1_Missense_Mutation_p.E84Q|RXFP1_uc011cja.1_Intron|RXFP1_uc010iqo.2_Missense_Mutation_p.E255Q|RXFP1_uc011cjb.1_Missense_Mutation_p.E201Q|RXFP1_uc010iqk.2_Missense_Mutation_p.E123Q|RXFP1_uc011cjc.1_Missense_Mutation_p.E174Q|RXFP1_uc011cjd.1_Missense_Mutation_p.E174Q|RXFP1_uc010iql.2_Intron|RXFP1_uc011cje.1_Missense_Mutation_p.E282Q|RXFP1_uc010iqm.2_Missense_Mutation_p.E222Q|RXFP1_uc011cjf.1_Missense_Mutation_p.E125Q|RXFP1_uc010iqn.2_Missense_Mutation_p.E201Q	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	255	Extracellular (Potential).|LRR 5.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CAGGGACCTTGAAGGCAACCA	0.264													0	0	0	0.234183	0	18	21										C	159547979	G	C	159547979	3	2	38	1	0	0	0	0	1	0	0	0	13759	1291	45	1	801	1	RXFP1	4	159547979	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	110998347	159547979	31606297	39	9323										
PLEKHG4B	153478	broad.mit.edu	37	chr5	163407	163407	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tggccagccgccccaggaaaCatccccagaagaaaatgata	9	13	0	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:163407C>G	uc003jak.2	+	11	2202	c.2152C>G	c.(2152-2154)CAT>GAT	p.H718D		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	718					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CCCCAGGAAACATCCCCAGAA	0.607													0	0	0	0.139131	0	67	82										G	163407	C	G	163407	3	3	38	1	0	0	0	0	1	0	0	0	12072	478	17	4	2194	4	PLEKHG4B	5	163407	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		163407	180751853	40	9324										
EGFLAM	133584	broad.mit.edu	37	chr5	38370443	38370443	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcaatccatgagcggatccaGatggactccatggttatcaa	9	10	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:38370443G>A	uc003jlc.1	+	6	915	c.591G>A	c.(589-591)CAG>CAA	p.Q197Q	EGFLAM_uc003jlb.1_Silent_p.Q197Q	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	197	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AGCGGATCCAGATGGACTCCA	0.507													0	0	0	0.235728	0	40	61										A	38370443	G	A	38370443	2	1	38	1	0	0	0	0	0	0	0	1	4966	933	33	1		1	EGFLAM	5	38370443	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	38207036	38370443	142544817	41	9325										
PAIP1	10605	broad.mit.edu	37	chr5	43547922	43547922	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaactgttcaatttcagtttCaaaactgccaggctgctctg	7	10	4	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:43547922C>G	uc003job.2	-	3	776	c.529G>C	c.(529-531)GAA>CAA	p.E177Q	PAIP1_uc003joa.2_Missense_Mutation_p.E98Q|PAIP1_uc010ivp.2_Missense_Mutation_p.E98Q|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E65Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	177	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATTTCAGTTTCAAAACTGCCA	0.398													0	0	0	0.268233	0	43	55										G	43547922	C	G	43547922	3	3	38	1	0	0	0	0	1	0	0	0	11396	835	29	1	946	1	PAIP1	5	43547922	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	5177479	43547922	137367338	42	9326										
KCNN2	3781	broad.mit.edu	37	chr5	113698898	113698898	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gactacgcgctcatcttcggCatgttcggcatcgtggtcat	11	12	3	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:113698898C>T	uc003kqo.2	+	1	883	c.426C>T	c.(424-426)GGC>GGT	p.G142G		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	142	Helical; Name=Segment S1; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TCATCTTCGGCATGTTCGGCA	0.612													0	0	0	0.173368	0	35	2										T	113698898	C	T	113698898	2	4	38	1	0	0	0	0	0	0	0	1	8079	697	25	2		2	KCNN2	5	113698898	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	70150976	113698898	67216362	43	9327										
FAM193B	54540	broad.mit.edu	37	chr5	176958345	176958345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gctgttggggactttgggctCcgtgctgttgatgaattcca	14	8	0	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr5:176958345C>T	uc003mhs.3	-	7	2703	c.1114G>A	c.(1114-1116)GAG>AAG	p.E372K	FAM193B_uc003mht.2_Missense_Mutation_p.E31K|FAM193B_uc003mhu.2_Intron|FAM193B_uc003mhv.2_Missense_Mutation_p.E31K|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	391											0						ACTTTGGGCTCCGTGCTGTTG	0.657													0	0	0	0.184627	0	5	0										T	176958345	C	T	176958345	3	4	38	1	0	0	0	0	1	0	0	0	5525	864	30	1	1271	1	FAM193B	5	176958345	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	63259447	176958345	3956915	44	9328										
RING1	6015	broad.mit.edu	37	chr6	33179090	33179090	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccctgctcccaagcgaccccGtggagggggcgcagggggga	18	14	0	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:33179090G>T	uc003odk.2	+	5	805	c.611G>T	c.(610-612)CGT>CTT	p.R204L	RING1_uc011dqx.1_Missense_Mutation_p.R204L|RING1_uc003odl.2_Missense_Mutation_p.R175L	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	204	Necessary for transcriptional repression (By similarity).|Nuclear localization signal (Potential).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						AAGCGACCCCGTGGAGGGGGC	0.711													1	0	4.54149e-19	0.249174	4.99241e-19	21	38										T	33179090	G	T	33179090	3	4	38	1	0	0	0	0	1	0	0	0	13374	1145	40	4	625	4	RING1	6	33179090	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08		33179090	137935977	45	9329										
CDKN1A	1026	broad.mit.edu	37	chr6	36651906	36651906	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaccggctggggatgtccgtCagaacccatgcggcagcaag	14	12	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:36651906C>T	uc003omm.3	+	2	150	c.28C>T	c.(28-30)CAG>TAG	p.Q10*	CDKN1A_uc011dtq.1_Nonsense_Mutation_p.Q44*|CDKN1A_uc003oml.2_Nonsense_Mutation_p.Q10*|CDKN1A_uc003omn.2_Nonsense_Mutation_p.Q10*	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	10					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GGATGTCCGTCAGAACCCATG	0.637									Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.26419	0	21	15										T	36651906	C	T	36651906	4	4	38	1	0	0	0	0	0	1	0	0	3158	827	29	1	30	1	CDKN1A	6	36651906	Nonsense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	3472816	36651906	134463161	46	9330										
CCND3	896	broad.mit.edu	37	chr6	41909293	41909293	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cgtagcgctcctccaggcggAgcaggctctgcaggacacgc	14	15	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:41909293A>C	uc003orn.2	-	1	260	c.95T>G	c.(94-96)CTC>CGC	p.L32R	CCND3_uc003orp.2_Intron|CCND3_uc011duk.1_Intron|CCND3_uc011dum.1_Intron|CCND3_uc003orm.2_5'Flank|CCND3_uc003oro.2_Missense_Mutation_p.L32R|CCND3_uc011dul.1_Missense_Mutation_p.L32R	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	32	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTCCAGGCGGAGCAGGCTCTG	0.552			T	IGH@	MM								0	0	0	0.248553	0	7	4										C	41909293	A	C	41909293	3	2	38	1	0	0	0	0	1	0	0	0	2918	304	11	5	803	5	CCND3	6	41909293	Missense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	5257387	41909293	129205774	47	9331										
MAD2L1BP	9587	broad.mit.edu	37	chr6	43608115	43608115	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gacaccgcaactgtggagaaGattggtttcgacccaagctc	11	11	0	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:43608115G>C	uc003ovv.2	+	3	706	c.670G>C	c.(670-672)GAT>CAT	p.D224H	MAD2L1BP_uc003ovu.2_Missense_Mutation_p.D256H	NM_014628	NP_055443	Q15013	MD2BP_HUMAN	MAD2L1 binding protein isoform 2	224					mitotic cell cycle checkpoint|regulation of exit from mitosis	cytoplasm|nucleus|spindle	protein binding				0	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000351)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CTGTGGAGAAGATTGGTTTCG	0.567													0	0	0	0.163468	0	34	25										C	43608115	G	C	43608115	3	2	38	1	0	0	0	0	1	0	0	0	9149	942	33	1	830	1	MAD2L1BP	6	43608115	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	1698822	43608115	127506952	48	9332										
TNFRSF21	27242	broad.mit.edu	37	chr6	47200581	47200581	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gctcttgactccaataatttCgaatagccggtctagtttgt	8	9	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr6:47200581C>G	uc003oyv.2	-	6	2321	c.1888G>C	c.(1888-1890)GAA>CAA	p.E630Q		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	630	Cytoplasmic (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			CCAATAATTTCGAATAGCCGG	0.493													0	0	0	0.139131	0	68	108										G	47200581	C	G	47200581	3	3	38	1	0	0	0	0	1	0	0	0	16292	893	31	1	83	1	TNFRSF21	6	47200581	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	3592466	47200581	123914486	49	9333										
DNAH11	8701	broad.mit.edu	37	chr7	21818711	21818711	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaaagaccatcgctgatgctGaggagcgaaaggtcaggcta	13	8	1	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:21818711G>C	uc003svc.2	+	58	9524	c.9493G>C	c.(9493-9495)GAG>CAG	p.E3165Q		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3165	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CGCTGATGCTGAGGAGCGAAA	0.463									Kartagener_syndrome				0	0	0	0.09319	0	12	11										C	21818711	G	C	21818711	3	2	38	1	0	0	0	0	1	0	0	0	4599	1291	45	1	9720	1	DNAH11	7	21818711	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08		21818711	137319952	50	9334										
ZNF479	90827	broad.mit.edu	37	chr7	57188745	57188745	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccacacttttacagcattttTtaaattgtaatttctcatgt	3	8	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:57188745T>C	uc010kzo.2	-	5	648	c.377A>G	c.(376-378)AAA>AGA	p.K126R		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ACAGCATTTTTTAAATTGTAA	0.368													0	0	0	0.09319	0	10	105										C	57188745	T	C	57188745	3	2	38	1	0	0	0	0	1	0	0	0	17930	1841	64	5	1201	5	ZNF479	7	57188745	Missense_Mutation	SNP	T	TCGA-CU-A3QU-01A-11D-A22Z-08	35370034	57188745	101949918	51	9335										
LIMK1	3984	broad.mit.edu	37	chr7	73535372	73535372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gctgttgcgatctggaccccGagaagaggtgagtggggtgg	19	7	1	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:73535372G>A	uc003uaa.1	+	15	1939	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.E558K	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	592	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				TCTGGACCCCGAGAAGAGGTG	0.672													0	0	0	0.139131	0	51	76										A	73535372	G	A	73535372	3	1	38	1	0	0	0	0	1	0	0	0	8801	1059	37	1	1832	1	LIMK1	7	73535372	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	16346627	73535372	85603291	52	9336										
CFTR	1080	broad.mit.edu	37	chr7	117232105	117232105	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ggtagcagctatttttatggGacattttcagaactccaaaa	8	7	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr7:117232105G>A	uc003vjd.2	+	14	2016	c.1884G>A	c.(1882-1884)GGG>GGA	p.G628G	CFTR_uc011knq.1_Silent_p.G34G	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	628	Cytoplasmic (Potential).|ABC transporter 1.		G -> R (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ATTTTTATGGGACATTTTCAG	0.343									Cystic_Fibrosis				0	0	0	0.139131	0	48	62										A	117232105	G	A	117232105	2	1	38	1	0	0	0	0	0	0	0	1	3294	1161	41	1		1	CFTR	7	117232105	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	43696733	117232105	41906558	53	9337										
TACC1	6867	broad.mit.edu	37	chr8	38677716	38677716	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gagtcgaggagctcacctctCaagcttgagtttgatttcac	10	10	3	2	rs61734982	byFrequency	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr8:38677716C>G	uc010lwp.2	+	3	1333	c.954C>G	c.(952-954)CTC>CTG	p.L318L	TACC1_uc011lby.1_Silent_p.L123L|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_Silent_p.L123L|TACC1_uc003xmc.3_Silent_p.L123L|TACC1_uc011lbz.1_Silent_p.L334L|TACC1_uc003xmb.3_Silent_p.L273L|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Silent_p.L318L|TACC1_uc011lcb.1_Silent_p.L123L|TACC1_uc011lcc.1_Silent_p.L123L|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Silent_p.L123L|TACC1_uc010lwq.2_Silent_p.L123L	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	318	Interaction with YEATS4.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			GCTCACCTCTCAAGCTTGAGT	0.527													0	0	0	0.301197	0	47	43										G	38677716	C	G	38677716	2	3	38	1	0	0	0	0	0	0	0	1	15498	813	29	1		1	TACC1	8	38677716	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		38677716	107686306	54	9338										
CYP7A1	1581	broad.mit.edu	37	chr8	59410812	59410812	+	Frame_Shift_Del	DEL	T	T	-													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gcagaagtagcaaagtgaaaTtttttccaatcaaaatattt							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr8:59410812delT	uc003xtm.3	-	2	360	c.297delA	c.(295-297)AAAfs	p.K99fs		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	99					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				CAAAGTGAAATTTTTTCCAAT	0.323									Neonatal_Giant_Cell_Hepatitis									29	133	---	---								-	59410812	T	-	59410812	7	5	38	1	0	1	0	1	0	0	0	0	4196	1490	52	0	1237	0	CYP7A1	8	59410812	Frame_Shift_Del	DEL	T	TCGA-CU-A3QU-01A-11D-A22Z-08	20733096	59410812	86953210	55	9339										
DCAF4L2	138009	broad.mit.edu	37	chr8	88886086	88886086	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atacggcaatagttggcgaaTctgaggaaacctagctggtt	12	7	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr8:88886086T>A	uc003ydz.2	-	1	211	c.114A>T	c.(112-114)AGA>AGT	p.R38S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	38										ovary(1)	1						AGTTGGCGAATCTGAGGAAAC	0.522													0	0	0	0.132662	0	15	58										A	88886086	T	A	88886086	3	1	38	1	0	0	0	0	1	0	0	0	4272	1432	50	5	1077	5	DCAF4L2	8	88886086	Missense_Mutation	SNP	T	TCGA-CU-A3QU-01A-11D-A22Z-08	29475274	88886086	57477936	56	9340										
MPDZ	8777	broad.mit.edu	37	chr9	13137991	13137991	+	Missense_Mutation	SNP	C	C	T													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tgcaatttgcaatcgaccatCttttcctgcagctccatttg							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:13137991C>T	uc010mia.1	-	28	4222	c.4165G>A	c.(4165-4167)GAT>AAT	p.D1389N	MPDZ_uc003zky.3_5'Flank|MPDZ_uc010mib.2_Missense_Mutation_p.D94N|MPDZ_uc010mhx.2_Missense_Mutation_p.D211N|MPDZ_uc011lmm.1_Missense_Mutation_p.D248N|MPDZ_uc003zkz.3_Missense_Mutation_p.D82N|MPDZ_uc010mhy.2_Missense_Mutation_p.D1389N|MPDZ_uc010mhz.2_Missense_Mutation_p.D1356N|MPDZ_uc011lmn.1_Missense_Mutation_p.D1356N|MPDZ_uc003zlb.3_Missense_Mutation_p.D1389N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1389	PDZ 8.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		AATCGACCATCTTTTCCTGCA	0.408													0	0	0	0.144211	0	31	19										T	13137991	C	T	13137991	3	4	38	1	0	0	0	0	1	0	0	0	9722	913	32	1	2032	1	MPDZ	9	13137991	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		13137991	128075440	57	9341	47	2								
MPDZ	8777	broad.mit.edu	37	chr9	13137996	13137996	+	Missense_Mutation	SNP	C	C	T													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tttgcaatcgaccatcttttCctgcagctccatttggatca							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:13137996C>T	uc010mia.1	-	28	4217	c.4160G>A	c.(4159-4161)GGA>GAA	p.G1387E	MPDZ_uc003zky.3_5'Flank|MPDZ_uc010mib.2_Missense_Mutation_p.G92E|MPDZ_uc010mhx.2_Missense_Mutation_p.G209E|MPDZ_uc011lmm.1_Missense_Mutation_p.G246E|MPDZ_uc003zkz.3_Missense_Mutation_p.G80E|MPDZ_uc010mhy.2_Missense_Mutation_p.G1387E|MPDZ_uc010mhz.2_Missense_Mutation_p.G1354E|MPDZ_uc011lmn.1_Missense_Mutation_p.G1354E|MPDZ_uc003zlb.3_Missense_Mutation_p.G1387E	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1387	PDZ 8.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACCATCTTTTCCTGCAGCTCC	0.408													0	0	0	0.116897	0	30	21										T	13137996	C	T	13137996	3	4	38	1	0	0	0	0	1	0	0	0	9722	855	30	1	2037	1	MPDZ	9	13137996	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	5	13137996	128075435	58	9342	47	2								
IFNA14	3448	broad.mit.edu	37	chr9	21239749	21239749	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ttgccatcaaattcctcctgGggaaattcaaagtcatgtct	7	10	4	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:21239749G>T	uc010mis.2	-	1	230	c.186C>A	c.(184-186)CCC>CCA	p.P62P	IFNA14_uc003zoo.1_RNA	NM_002172	NP_002163	P01570	IFN14_HUMAN	interferon, alpha 14 precursor	62					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATTCCTCCTGGGGAAATTCAA	0.473													1	0	3.07184e-27	0.139131	3.42543e-27	67	173										T	21239749	G	T	21239749	2	4	38	1	0	0	0	0	0	0	0	1	7534	1219	43	4		4	IFNA14	9	21239749	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	8101753	21239749	119973682	59	9343										
RUSC2	9853	broad.mit.edu	37	chr9	35560350	35560350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tgtgggtgcctcagaaggtgGagaagaggaagaggaagaag	19	3	1	5			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:35560350G>A	uc003zww.2	+	10	3968	c.3713G>A	c.(3712-3714)GGA>GAA	p.G1238E	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.G1238E	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1238						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TCagaaggtggagaagaggaa	0.557													0	0	0	0.058154	0	9	18										A	35560350	G	A	35560350	3	1	38	1	0	0	0	0	1	0	0	0	13751	1174	41	1	3747	1	RUSC2	9	35560350	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	14320601	35560350	105653081	60	9344										
SMC2	10592	broad.mit.edu	37	chr9	106880491	106880491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atgtggctctttccttggttGaatataaaccagaacttcag	8	8	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:106880491G>A	uc004bbv.2	+	15	2119	c.1831G>A	c.(1831-1833)GAA>AAA	p.E611K	SMC2_uc004bbu.1_Missense_Mutation_p.E611K|SMC2_uc004bbw.2_Missense_Mutation_p.E611K|SMC2_uc011lvl.1_Missense_Mutation_p.E611K|SMC2_uc004bbx.2_Missense_Mutation_p.E611K	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	611	Flexible hinge.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						TTCCTTGGTTGAATATAAACC	0.388													0	0	0	0.131918	0	43	6										A	106880491	G	A	106880491	3	1	38	1	0	0	0	0	1	0	0	0	14783	1291	45	1	1885	1	SMC2	9	106880491	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	71320141	106880491	34332940	61	9345										
C9orf5	23731	broad.mit.edu	37	chr9	111853251	111853251	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atccacaggttcaaccagatCtgcatgacgacaatggccca	8	13	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr9:111853251C>A	uc004bdt.3	-	5	1133	c.1101G>T	c.(1099-1101)CAG>CAT	p.Q367H	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.Q367H	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	367	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		TCAACCAGATCTGCATGACGA	0.443													1	0	7.26314e-15	0.125774	7.81796e-15	27	7										A	111853251	C	A	111853251	3	1	38	1	0	0	0	0	1	0	0	0	2486	912	32	3	1594	3	C9orf5	9	111853251	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	4972760	111853251	29360180	62	9346										
PARD3	56288	broad.mit.edu	37	chr10	34630676	34630689	+	Frame_Shift_Del	DEL	ACCTGTCATCTTCT	ACCTGTCATCTTCT	-													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atgtggaggaagcactggcaAcctgtcatcttctataatga							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr10:34630676_34630689delACCTGTCATCTTCT	uc010qej.1	-	16	2283_2296	c.2283_2296delAGAAGATGACAGGT	c.(2281-2298)ATAGAAGATGACAGGTTGfs	p.I761fs	PARD3_uc010qek.1_Frame_Shift_Del_p.I758fs|PARD3_uc010qel.1_Frame_Shift_Del_p.I761fs|PARD3_uc010qem.1_Frame_Shift_Del_p.I745fs|PARD3_uc010qen.1_Frame_Shift_Del_p.I745fs|PARD3_uc010qeo.1_Frame_Shift_Del_p.I745fs|PARD3_uc010qep.1_Frame_Shift_Del_p.I701fs|PARD3_uc010qeq.1_Frame_Shift_Del_p.I701fs|PARD3_uc001ixo.1_Frame_Shift_Del_p.I475fs|PARD3_uc001ixp.1_Frame_Shift_Del_p.I623fs|PARD3_uc001ixq.1_Frame_Shift_Del_p.I745fs|PARD3_uc001ixr.1_Frame_Shift_Del_p.I758fs|PARD3_uc001ixt.1_Frame_Shift_Del_p.I579fs|PARD3_uc001ixu.1_Frame_Shift_Del_p.I704fs|PARD3_uc001ixs.1_Frame_Shift_Del_p.I414fs	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	761_766	Interacts with PRKCZ (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				AGCACTGGCAACCTGTCATCTTCTATAATGACAG	0.481																		32	83	---	---								-	34630689	ACCTGTCATCTTCT	-	34630676	7	5	38	1	0	1	0	1	0	0	0	0	11443	40	2	0	1849	0	PARD3	10	34630676	Frame_Shift_Del	DEL	ACCTGTCATCTTCT	TCGA-CU-A3QU-01A-11D-A22Z-08		34630676	100904071	63	9347										
LRDD	55367	broad.mit.edu	37	chr11	800588	800596	+	In_Frame_Del	DEL	CGCCCTCGA	CGCCCTCGA	-													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gaaggccgcaaagaactcttCgccctcgaacatctccaccg					rs151136652		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:800588_800596delCGCCCTCGA	uc001lro.1	-	12	2130_2138	c.1988_1996delTCGAGGGCG	c.(1987-1998)TTCGAGGGCGAA>TAA	p.663_666FEGE>*	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_In_Frame_Del_p.663_666FEGE>*|LRDD_uc001lrl.1_In_Frame_Del_p.506_509FEGE>*|LRDD_uc001lrm.1_In_Frame_Del_p.350_353FEGE>*|LRDD_uc001lrn.1_In_Frame_Del_p.506_509FEGE>*|LRDD_uc001lrp.1_In_Frame_Del_p.325_328FEGE>*	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	663_666					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGAACTCTTCGCCCTCGAACATCTCCAC	0.684																		13	19	---	---								-	800596	CGCCCTCGA	-	800588	7	5	38	1	0	1	0	1	0	0	0	0	8936	893	31	0	756	0	LRDD	11	800588	In_Frame_Del	DEL	CGCCCTCGA	TCGA-CU-A3QU-01A-11D-A22Z-08		800588	134205928	64	9348										
GALNTL4	374378	broad.mit.edu	37	chr11	11362441	11362441	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	acttcagccaccctgagagcGttcctgcggacatgggcggt	13	13	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:11362441G>A	uc001mjo.2	-	7	1624	c.1203C>T	c.(1201-1203)AAC>AAT	p.N401N		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	401	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		CCCTGAGAGCGTTCCTGCGGA	0.582													0	0	0	0.139131	0	103	105										A	11362441	G	A	11362441	2	1	38	1	0	0	0	0	0	0	0	1	6223	1136	40	2		2	GALNTL4	11	11362441	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	10561853	11362441	123644075	65	9349										
PIK3C2A	5286	broad.mit.edu	37	chr11	17113773	17113773	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ttaactcaattttccttttgGctgctacatcttttatgtgt	5	8	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:17113773G>C	uc001mmq.3	-	28	4568	c.4502C>G	c.(4501-4503)GCC>GGC	p.A1501G	PIK3C2A_uc009ygu.1_Missense_Mutation_p.A104G|PIK3C2A_uc010rcw.1_Missense_Mutation_p.A1121G|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1501	PX.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTTCCTTTTGGCTGCTACATC	0.323													0	0	0	0.134883	0	32	39										C	17113773	G	C	17113773	3	2	38	1	0	0	0	0	1	0	0	0	11909	1203	42	4	578	4	PIK3C2A	11	17113773	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	5751332	17113773	117892743	66	9350										
KCNJ11	3767	broad.mit.edu	37	chr11	17408909	17408909	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gaagatgctgttgccacccaCgccgttctccatggggatgt	12	12	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:17408909C>T	uc001mna.2	-	1	1298	c.730G>A	c.(730-732)GTG>ATG	p.V244M	KCNJ11_uc001mnb.3_Missense_Mutation_p.V157M	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	244						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		TTGCCACCCACGCCGTTCTCC	0.627											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.225048	0	39	46										T	17408909	C	T	17408909	3	4	38	1	0	0	0	0	1	0	0	0	8045	536	19	2	446	2	KCNJ11	11	17408909	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	295136	17408909	117597607	67	9351										
ACCS	84680	broad.mit.edu	37	chr11	44089204	44089204	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	acccttcctcaaaaggacttCagggctcccaccacctgtct	6	17	3	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:44089204C>T	uc009yks.1	+	2	171	c.27C>T	c.(25-27)TTC>TTT	p.F9F	ACCS_uc010rfm.1_5'UTR|ACCS_uc010rfn.1_Silent_p.F9F|ACCS_uc001mxx.2_Silent_p.F9F	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	9							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						AAAAGGACTTCAGGGCTCCCA	0.537													0	0	0	0.225048	0	37	34										T	44089204	C	T	44089204	2	4	38	1	0	0	0	0	0	0	0	1	133	825	29	1		1	ACCS	11	44089204	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	26680295	44089204	90917312	68	9352										
FOLH1	2346	broad.mit.edu	37	chr11	49227726	49227726	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gaggattttataaaccacccTgaaaaatacatccaaaaata	4	8	0	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:49227726T>G	uc001ngy.2	-	2	380	c.119_splice	c.e2-1	p.G40_splice	FOLH1_uc001ngz.2_Splice_Site_p.G40_splice|FOLH1_uc009yly.2_Splice_Site_p.G25_splice|FOLH1_uc009ylz.2_Splice_Site_p.G25_splice|FOLH1_uc009yma.2_Splice_Site|FOLH1_uc001nha.2_Splice_Site_p.G25_splice	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1						proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TAAACCACCCTGAAAAATACA	0.299													0	0	0	0.069234	0	10	77										G	49227726	T	G	49227726	5	3	38	1	0	0	0	0	0	0	1	0	5979	1594	55	5	2207	5	FOLH1	11	49227726	Splice_Site	SNP	T	TCGA-CU-A3QU-01A-11D-A22Z-08	5138522	49227726	85778790	69	9353										
VWCE	220001	broad.mit.edu	37	chr11	61036487	61036487	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cttgcagctcaccgagccatCtgcctggaggaaggaggaac	13	12	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:61036487C>G	uc001nra.2	-	15	2068	c.1789G>C	c.(1789-1791)GAT>CAT	p.D597H	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	597	VWFC 4.					extracellular region	calcium ion binding			ovary(1)	1						ACCGAGCCATCTGCCTGGAGG	0.612													0	0	0	0.09319	0	12	12										G	61036487	C	G	61036487	3	3	38	1	0	0	0	0	1	0	0	0	17242	913	32	1	1102	1	VWCE	11	61036487	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	11808761	61036487	73970029	70	9354										
GRIA4	2893	broad.mit.edu	37	chr11	105797472	105797472	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tttatccatgtttagatcccTctcaggtcgaattgttggag	9	8	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:105797472T>C	uc001pix.2	+	13	2299	c.1853T>C	c.(1852-1854)CTC>CCC	p.L618P	GRIA4_uc001piw.2_Missense_Mutation_p.L618P	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	618	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	tttagaTCCCTCTCAGGTCGA	0.259													0	0	0	0.294199	0	21	75										C	105797472	T	C	105797472	3	2	38	1	0	0	0	0	1	0	0	0	6770	1551	54	5	1936	5	GRIA4	11	105797472	Missense_Mutation	SNP	T	TCGA-CU-A3QU-01A-11D-A22Z-08	44760985	105797472	29209044	71	9355										
TECTA	7007	broad.mit.edu	37	chr11	120998486	120998486	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	acagtgcagtgcccgagcttCagccactactccgtgtgcac	10	15	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr11:120998486C>T	uc010rzo.1	+	8	1800	c.1800C>T	c.(1798-1800)TTC>TTT	p.F600F		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	600	TIL 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCCCGAGCTTCAGCCACTACT	0.622													0	0	0	0.301197	0	41	43										T	120998486	C	T	120998486	2	4	38	1	0	0	0	0	0	0	0	1	15744	825	29	1		1	TECTA	11	120998486	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	15201014	120998486	14008030	72	9356										
NEUROD4	58158	broad.mit.edu	37	chr12	55420322	55420322	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcccaaaatgaggtgaaggaGgaagagagcagaccaggtac	14	7	0	4			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr12:55420322G>C	uc001sgp.3	+	2	477	c.99G>C	c.(97-99)GAG>GAC	p.E33D		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	33					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						AGGTGAAGGAGGAAGAGAGCA	0.393													0	0	0	0.163468	0	32	11										C	55420322	G	C	55420322	3	2	38	1	0	0	0	0	1	0	0	0	10350	991	35	4	101	4	NEUROD4	12	55420322	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08		55420322	78431573	73	9357										
MTERFD3	80298	broad.mit.edu	37	chr12	107372070	107372070	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ttctcttggtctttaatagtAaagaaagattctggaaactg	8	5	3	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr12:107372070A>G	uc001tme.1	-	2	2242	c.423T>C	c.(421-423)TTT>TTC	p.F141F	MTERFD3_uc001tmf.1_Silent_p.F141F|MTERFD3_uc001tmg.1_Silent_p.F141F|MTERFD3_uc001tmh.1_Silent_p.F141F	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						CTTTAATAGTAAAGAAAGATT	0.398													0	0	0	0.11911	0	15	77										G	107372070	A	G	107372070	2	3	38	1	0	0	0	0	0	0	0	1	9921	359	13	5		5	MTERFD3	12	107372070	Silent	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	51951748	107372070	26479825	74	9358										
DCLK1	9201	broad.mit.edu	37	chr13	36396889	36396889	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	caggttctctggcttgatatCacggtggacgatgttcaggc	13	9	3	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr13:36396889C>T	uc001uvf.2	-	11	1764	c.1531G>A	c.(1531-1533)GAT>AAT	p.D511N	DCLK1_uc001uve.3_Missense_Mutation_p.D204N|DCLK1_uc010teh.1_Missense_Mutation_p.D204N|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	511	Protein kinase.	Proton acceptor (By similarity).			cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GGCTTGATATCACGGTGGACG	0.458													0	0	0	0.214465	0	36	40										T	36396889	C	T	36396889	3	4	38	1	0	0	0	0	1	0	0	0	4291	826	29	1	690	1	DCLK1	13	36396889	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		36396889	78772989	75	9359										
ZNF828	283489	broad.mit.edu	37	chr13	115089918	115089918	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gtgagtctcagaaacttgccCctgttccttctccagaacca	7	14	2	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr13:115089918C>T	uc010ahb.2	+	3	930	c.601C>T	c.(601-603)CCT>TCT	p.P201S	ZNF828_uc001vuv.2_Missense_Mutation_p.P201S|ZNF828_uc010tko.1_Missense_Mutation_p.P201S	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	201	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		GAAACTTGCCCCTGTTCCTTC	0.488													0	0	0	0.139131	0	94	112										T	115089918	C	T	115089918	3	4	38	1	0	0	0	0	1	0	0	0	18178	623	22	2	603	2	ZNF828	13	115089918	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	78693029	115089918	79960	76	9360										
RABGGTA	5875	broad.mit.edu	37	chr14	24739609	24739609	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tggcaaaatcagggttggctCccagaatctggcttgtcagt	12	9	3	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:24739609C>T	uc001wof.2	-	3	592	c.170G>A	c.(169-171)GGA>GAA	p.G57E	RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Missense_Mutation_p.G57E|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	57	PFTA 1.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		AGGGTTGGCTCCCAGAATCTG	0.537													0	0	0	0.160694	0	18	1										T	24739609	C	T	24739609	3	4	38	1	0	0	0	0	1	0	0	0	12967	855	30	1	1589	1	RABGGTA	14	24739609	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		24739609	82609931	77	9361			1	36		3	3	534	C		1.988096e-06
RABGGTA	5875	broad.mit.edu	37	chr14	24739631	24739631	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cagaatctggcttgtcagttCcagcacggactcatccagct	9	13	3	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:24739631C>T	uc001wof.2	-	3	570	c.148G>A	c.(148-150)GAA>AAA	p.E50K	RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Missense_Mutation_p.E50K|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	50	PFTA 1.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		CTTGTCAGTTCCAGCACGGAC	0.522													0	0	0	0.160694	0	16	1										T	24739631	C	T	24739631	3	4	38	1	0	0	0	0	1	0	0	0	12967	864	30	1	1611	1	RABGGTA	14	24739631	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	22	24739631	82609909	78	9362			1	36		3	3	534	C		1.988096e-06
RABGGTA	5875	broad.mit.edu	37	chr14	24740142	24740142	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcttctgacgtcttcaccttCaggcgtccgtgctacaagga	9	13	5	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:24740142C>T	uc001wof.2	-	2	437	c.15G>A	c.(13-15)CTG>CTA	p.L5L	RABGGTA_uc001woe.2_5'Flank|RABGGTA_uc001wog.2_Silent_p.L5L|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	5					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		TCTTCACCTTCAGGCGTCCGT	0.557													0	0	0	0.047766	0	8	2										T	24740142	C	T	24740142	2	4	38	1	0	0	0	0	0	0	0	1	12967	813	29	1		1	RABGGTA	14	24740142	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	511	24740142	82609398	79	9363			1	36		3	3	534	C		1.988096e-06
FAM179B	23116	broad.mit.edu	37	chr14	45432049	45432049	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tttgtatcgggcactgggccGagtgcttgtggaaggaggta	17	6	0	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:45432049G>C	uc001wvv.2	+	1	634	c.425G>C	c.(424-426)CGA>CCA	p.R142P	FAM179B_uc001wvw.2_Missense_Mutation_p.R142P|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R142P|FAM179B_uc001wvu.2_Missense_Mutation_p.R142P	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	142							binding			skin(2)|upper_aerodigestive_tract(1)	3						GCACTGGGCCGAGTGCTTGTG	0.627													0	0	0	0.139131	0	54	11										C	45432049	G	C	45432049	3	2	38	1	0	0	0	0	1	0	0	0	5506	1058	37	1	427	1	FAM179B	14	45432049	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	20691907	45432049	61917491	80	9364										
FAM179B	23116	broad.mit.edu	37	chr14	45432303	45432303	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aacaaggactggaaagtaccGatgcccgacttagagcttcc	10	11	0	1	rs148819135		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:45432303G>C	uc001wvv.2	+	1	888	c.679G>C	c.(679-681)GAT>CAT	p.D227H	FAM179B_uc001wvw.2_Missense_Mutation_p.D227H|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.D227H|FAM179B_uc001wvu.2_Missense_Mutation_p.D227H	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	227							binding			skin(2)|upper_aerodigestive_tract(1)	3						GGAAAGTACCGATGCCCGACT	0.493													0	0	0	0.139131	0	57	6										C	45432303	G	C	45432303	3	2	38	1	0	0	0	0	1	0	0	0	5506	1058	37	1	681	1	FAM179B	14	45432303	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	254	45432303	61917237	81	9365										
TTC8	123016	broad.mit.edu	37	chr14	89307466	89307466	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	caggcactatggaacaggctAtcagaacacccagaaccgcc	9	14	1	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr14:89307466A>G	uc010ath.2	+	4	519	c.385A>G	c.(385-387)ATC>GTC	p.I129V	TTC8_uc010atg.1_RNA|TTC8_uc001xxl.2_5'UTR|TTC8_uc010ati.2_5'UTR|TTC8_uc001xxm.2_Missense_Mutation_p.I129V|TTC8_uc010atj.2_Intron|TTC8_uc001xxi.2_Missense_Mutation_p.I139V|TTC8_uc001xxj.2_Missense_Mutation_p.I129V|TTC8_uc001xxk.2_Missense_Mutation_p.I129V	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	139					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						GGAACAGGCTATCAGAACACC	0.527									Bardet-Biedl_syndrome				0	0	0	0.219247	0	20	55										G	89307466	A	G	89307466	3	3	38	1	0	0	0	0	1	0	0	0	16711	449	16	5	433	5	TTC8	14	89307466	Missense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	43875163	89307466	18042074	82	9366										
MYO9A	4649	broad.mit.edu	37	chr15	72146901	72146901	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaattgtcgagatgacagctCtggatcatactaaatgaaag	9	6	2	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:72146901C>G	uc002atl.3	-	35	6636	c.6163G>C	c.(6163-6165)GAG>CAG	p.E2055Q	MYO9A_uc002atj.2_5'UTR|MYO9A_uc002atk.2_Missense_Mutation_p.E850Q	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2055	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GATGACAGCTCTGGATCATAC	0.348													0	0	0	0.139131	0	53	48										G	72146901	C	G	72146901	3	3	38	1	0	0	0	0	1	0	0	0	10084	922	32	1	1515	1	MYO9A	15	72146901	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		72146901	30384491	83	9367										
TM6SF1	53346	broad.mit.edu	37	chr15	83776476	83776476	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ggtcttcgtgctgtccctctCggccatcccggtcacctatg	10	16	3	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:83776476C>G	uc002bjp.2	+	1	153	c.44C>G	c.(43-45)TCG>TGG	p.S15W	TM6SF1_uc010bmq.2_Missense_Mutation_p.S15W|TM6SF1_uc002bjq.2_Missense_Mutation_p.S15W|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	15	Helical; (Potential).					integral to membrane				ovary(1)	1						CTGTCCCTCTCGGCCATCCCG	0.567													0	0	0	0.217242	0	5	4										G	83776476	C	G	83776476	3	3	38	1	0	0	0	0	1	0	0	0	15969	893	31	1	46	1	TM6SF1	15	83776476	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	11629575	83776476	18754916	84	9368										
FANCI	55215	broad.mit.edu	37	chr15	89858609	89858609	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ttcgagaggatggtgaagatGaaaatgaagaggtcagtgct	15	3	1	6			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:89858609G>A	uc010bnp.1	+	37	4003	c.3913G>A	c.(3913-3915)GAA>AAA	p.E1305K	FANCI_uc002bnm.1_Missense_Mutation_p.E1245K|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.E1065K|FANCI_uc002bnq.1_Missense_Mutation_p.E718K	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1305					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TGGTGAAGATGAAAATGAAGA	0.498								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.125774	0	31	39										A	89858609	G	A	89858609	3	1	38	1	0	0	0	0	1	0	0	0	5669	1291	45	1	4055	1	FANCI	15	89858609	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	6082133	89858609	12672783	85	9369										
CHD2	1106	broad.mit.edu	37	chr15	93540489	93540489	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	taaactttctttagatactgCttaacctgtcgtgtcaaagc	6	9	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:93540489C>G	uc002bsp.2	+	30	4316	c.3741C>G	c.(3739-3741)TGC>TGG	p.C1247W	CHD2_uc002bso.1_Missense_Mutation_p.C1247W	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1247					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TTAGATACTGCTTAACCTGTC	0.398													0	0	0	0.249174	0	24	48										G	93540489	C	G	93540489	3	3	38	1	0	0	0	0	1	0	0	0	3325	805	28	4	3859	4	CHD2	15	93540489	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	3681880	93540489	8990903	86	9370			2	37		2	2	16	C		5.620593e-05
CHD2	1106	broad.mit.edu	37	chr15	93540504	93540504	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tactgcttaacctgtcgtgtCaaagctgcacattttgatgt	8	9	1	1	rs141696596	by1000genomes	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr15:93540504C>G	uc002bsp.2	+	30	4331	c.3756C>G	c.(3754-3756)GTC>GTG	p.V1252V	CHD2_uc002bso.1_Silent_p.V1252V	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1252					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCTGTCGTGTCAAAGCTGCAC	0.388													0	0	0	0.116897	0	30	46										G	93540504	C	G	93540504	2	3	38	1	0	0	0	0	0	0	0	1	3325	813	29	1		1	CHD2	15	93540504	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	15	93540504	8990888	87	9371			2	37		2	2	16	C		5.620593e-05
GSPT1	2935	broad.mit.edu	37	chr16	12009530	12009531	+	In_Frame_Ins	INS	-	-	CCG													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tgctgctgccgctgctgctcINSccgccgccgccgccgccgcc					rs71408216		TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr16:12009530_12009531insCCG	uc002dbt.2	-	1	295_296	c.47_48insCGG	c.(46-48)GGG>GGCGGG	p.16_16G>GG	GSPT1_uc002dbu.2_In_Frame_Ins_p.16_16G>GG|GSPT1_uc010bux.2_Intron	NM_002094	NP_002085	P15170	ERF3A_HUMAN	G1 to S phase transition 1 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation	intracellular	GTP binding|GTPase activity|protein binding|translation release factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						cgctgctgctcccgccgccgcc	0.332																		5	2	---	---								CCG	12009531	-	CCG	12009530	7	5	38	1	0	1	1	0	0	0	0	0	6826	842	30	0	1925	0	GSPT1	16	12009530	In_Frame_Ins	INS	-	TCGA-CU-A3QU-01A-11D-A22Z-08		12009530	78345223	88	9372										
TNRC6A	27327	broad.mit.edu	37	chr16	24815516	24815516	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aggaatgttacaagacaaacGaatggagatagataaacata	9	4	0	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr16:24815516G>A	uc002dmm.2	+	12	3827	c.3713G>A	c.(3712-3714)CGA>CAA	p.R1238Q	TNRC6A_uc010bxs.2_Missense_Mutation_p.R985Q|TNRC6A_uc002dmn.2_Missense_Mutation_p.R985Q|TNRC6A_uc002dmo.2_Missense_Mutation_p.R926Q|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_5'Flank	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1238	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CAAGACAAACGAATGGAGATA	0.398													0	0	0	0.099896	0	27	62										A	24815516	G	A	24815516	3	1	38	1	0	0	0	0	1	0	0	0	16337	1058	37	1	3759	1	TNRC6A	16	24815516	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	12805986	24815516	65539237	89	9373										
FBXW10	10517	broad.mit.edu	37	chr17	18671866	18671866	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gactctcagtggccatgaggGagccgtgaaatgcctgttct	13	10	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:18671866G>A	uc002guk.2	+	10	1956	c.1724G>A	c.(1723-1725)GGA>GAA	p.G575E	FBXW10_uc002guj.2_Missense_Mutation_p.G575E|FBXW10_uc002gul.2_Missense_Mutation_p.G604E|FBXW10_uc010cqh.1_Missense_Mutation_p.G575E	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	575	WD 6.									ovary(1)	1						GGCCATGAGGGAGCCGTGAAA	0.527													0	0	0	0.204396	0	19	39										A	18671866	G	A	18671866	3	1	38	1	0	0	0	0	1	0	0	0	5763	1174	41	1	1762	1	FBXW10	17	18671866	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08		18671866	62523344	90	9374										
RHBDL3	162494	broad.mit.edu	37	chr17	30615898	30615898	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aggccctgctggaggagaagGggctgagcctctcgcagcga	17	11	1	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:30615898G>A	uc002hhe.1	+	4	396	c.382G>A	c.(382-384)GGG>AGG	p.G128R	RHBDL3_uc010csw.1_Missense_Mutation_p.G120R|RHBDL3_uc010csx.1_Missense_Mutation_p.G128R|RHBDL3_uc010csy.1_Missense_Mutation_p.G30R|RHBDL3_uc002hhf.1_Missense_Mutation_p.G30R	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	128					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				GGAGGAGAAGGGGCTGAGCCT	0.592													0	0	0	0.189662	0	20	17										A	30615898	G	A	30615898	3	1	38	1	0	0	0	0	1	0	0	0	13323	1232	43	2	396	2	RHBDL3	17	30615898	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	11944032	30615898	50579312	91	9375										
SLFN12L	342615	broad.mit.edu	37	chr17	33807197	33807197	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcccagcagctaagccatttCcacgcagaaattcttttctg	6	13	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:33807197C>A	uc002hjn.2	-	3	998	c.119G>T	c.(118-120)GGA>GTA	p.G40V		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						TAAGCCATTTCCACGCAGAAA	0.398													1	0	1.15088e-07	0.146539	1.18924e-07	17	15										A	33807197	C	A	33807197	3	1	38	1	0	0	0	0	1	0	0	0	14735	855	30	3	1746	3	SLFN12L	17	33807197	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	3191299	33807197	47388013	92	9376										
DNAJC7	7266	broad.mit.edu	37	chr17	40169378	40169378	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctcttcgcctcttggtcgtcGagcagctccggctcggtcgc	12	16	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:40169378G>A	uc002hyo.2	-	1	294	c.57C>T	c.(55-57)CTC>CTT	p.L19L	DNAJC7_uc010wgb.1_5'Flank|DNAJC7_uc010wgc.1_5'UTR|DNAJC7_uc002hyp.2_5'UTR|DNAJC7_uc010cxw.2_5'Flank|NKIRAS2_uc002hyq.2_5'Flank|NKIRAS2_uc010wgd.1_5'Flank|NKIRAS2_uc002hyr.2_5'Flank|NKIRAS2_uc002hys.2_5'Flank|NKIRAS2_uc010wge.1_5'Flank|NKIRAS2_uc002hyt.2_5'Flank	NM_003315	NP_003306	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	19					chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding			ovary(1)	1		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				CTTGGTCGTCGAGCAGCTCCG	0.657													0	0	0	0.139131	0	52	72										A	40169378	G	A	40169378	2	1	38	1	0	0	0	0	0	0	0	1	4654	1045	37	1		1	DNAJC7	17	40169378	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	6362181	40169378	41025832	93	9377										
MAP3K14	9020	broad.mit.edu	37	chr17	43345029	43345029	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gcccttggcgaaagctctctCggctgggcatggagggtctg	16	11	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:43345029C>T	uc002iiw.1	-	13	2179	c.2070G>A	c.(2068-2070)CCG>CCA	p.P690P	LOC100133991_uc010dah.2_Intron|LOC100133991_uc002iit.3_Intron|LOC100133991_uc010dai.2_Intron|MAP3K14_uc002iiu.1_Silent_p.P220P|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Silent_p.P274P	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	690					cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						AAAGCTCTCTCGGCTGGGCAT	0.607													0	0	0	0.131918	0	46	60										T	43345029	C	T	43345029	2	4	38	1	0	0	0	0	0	0	0	1	9248	871	31	1		1	MAP3K14	17	43345029	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	3175651	43345029	37850181	94	9378										
ABCC3	8714	broad.mit.edu	37	chr17	48741058	48741058	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	acagcatcctgatcaggtttAtctccaaccccatggccccc	6	17	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:48741058A>G	uc002isl.2	+	9	1095	c.1015A>G	c.(1015-1017)ATC>GTC	p.I339V	ABCC3_uc002isk.3_Missense_Mutation_p.I339V|ABCC3_uc002ism.2_Missense_Mutation_p.I21V	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	339	Extracellular (By similarity).|ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GATCAGGTTTATCTCCAACCC	0.587													0	0	0	0.108266	0	27	49										G	48741058	A	G	48741058	3	3	38	1	0	0	0	0	1	0	0	0	54	449	16	5	1049	5	ABCC3	17	48741058	Missense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	5396029	48741058	32454152	95	9379										
UNC13D	201294	broad.mit.edu	37	chr17	73832317	73832317	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tggtgctgctgcttcaggtgGaaccattcagtggtgccagt	14	9	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:73832317G>A	uc002jpp.2	-	16	1790	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F	UNC13D_uc010wsk.1_Silent_p.F470F|UNC13D_uc002jpq.1_Silent_p.F120F|UNC13D_uc010dgq.1_Silent_p.F266F	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	470	Interaction with RAB27A.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTTCAGGTGGAACCATTCAG	0.667									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.058154	0	10	9										A	73832317	G	A	73832317	2	1	38	1	0	0	0	0	0	0	0	1	16984	1165	41	1		1	UNC13D	17	73832317	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	25091259	73832317	7362893	96	9380										
CANT1	124583	broad.mit.edu	37	chr17	76993384	76993384	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tccaggtctgcgataactgcGattcgataccgaatcccagc	9	13	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:76993384G>A	uc002jwn.2	-	4	760	c.321C>T	c.(319-321)ATC>ATT	p.I107I	CANT1_uc002jwk.2_Silent_p.I107I|CANT1_uc002jwj.2_Silent_p.I107I|CANT1_uc002jwl.2_RNA|CANT1_uc002jwm.1_5'Flank	NM_001159772	NP_001153244	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	107	Lumenal (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity				0			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			CGATAACTGCGATTCGATACC	0.577			T	ETV4	prostate								0	0	0	0.139131	0	109	127										A	76993384	G	A	76993384	2	1	38	1	0	0	0	0	0	0	0	1	2617	1048	37	1		1	CANT1	17	76993384	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	3161067	76993384	4201826	97	9381										
THOC4	10189	broad.mit.edu	37	chr17	79847100	79847100	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctgcttcatggccttcagggCatctgccttccgctcaaagt	9	14	4	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:79847100C>T	uc002kbu.2	-	3	502	c.496G>A	c.(496-498)GCC>ACC	p.A166T	ANAPC11_uc002kbv.1_5'Flank|ANAPC11_uc002kbw.1_5'Flank|ANAPC11_uc002kbx.1_5'Flank|ANAPC11_uc002kby.1_5'Flank|ANAPC11_uc002kbz.1_5'Flank|ANAPC11_uc002kca.1_5'Flank|ANAPC11_uc002kcb.1_5'Flank|ANAPC11_uc002kcc.1_5'Flank	NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	159	RRM.|Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GCCTTCAGGGCATCTGCCTTC	0.582													0	0	0	0.279207	0	26	26										T	79847100	C	T	79847100	3	4	38	1	0	0	0	0	1	0	0	0	15864	710	25	2	314	2	THOC4	17	79847100	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	2853716	79847100	1348110	98	9382										
DCXR	51181	broad.mit.edu	37	chr17	79994847	79994847	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cagcgcccgctcggtggcctCccagtcacccaggtccacgc	11	20	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:79994847C>G	uc002kdg.2	-	3	208	c.193G>C	c.(193-195)GAG>CAG	p.E65Q		NM_016286	NP_057370	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	65					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity				0	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			TCGGTGGCCTCCCAGTCACCC	0.677													0	0	0	0.184627	0	4	6										G	79994847	C	G	79994847	3	3	38	1	0	0	0	0	1	0	0	0	4319	864	30	1	565	1	DCXR	17	79994847	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	147747	79994847	1200363	99	9383										
HEXDC	284004	broad.mit.edu	37	chr17	80400259	80400259	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ggacgttgctcaggacccctGaggggagagctcatgccagg	16	11	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr17:80400259G>A	uc002kew.2	+	12	1511	c.1460G>A	c.(1459-1461)TGA>TAA	p.*487*	HEXDC_uc002kev.3_Missense_Mutation_p.E517K|HEXDC_uc010diq.2_Silent_p.L489L|HEXDC_uc010wvm.1_RNA			Q8WVB3	HEXDC_HUMAN	SubName: Full=Hexosaminidase (Glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_c; SubName: Full=Hexosaminidase D;	487					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			ovary(1)|skin(1)	2	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CAGGACCCCTGAGGGGAGAGC	0.701													0	0	0	0.125774	0	30	31										A	80400259	G	A	80400259	2	1	38	1	0	0	0	0	0	0	0	1	7075	1291	45	1		1	HEXDC	17	80400259	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	405412	80400259	794951	100	9384										
C18orf19	125228	broad.mit.edu	37	chr18	13681707	13681707	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaatgtcttcttgaatcgttGataaagactaatagatttgt	7	4	2	4			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr18:13681707G>C	uc010dlh.2	-	3	802	c.370C>G	c.(370-372)CAA>GAA	p.Q124E	C18orf19_uc010dlg.2_Missense_Mutation_p.Q124E|C18orf19_uc010dli.2_Missense_Mutation_p.Q124E|C18orf19_uc002ksj.3_Missense_Mutation_p.Q124E|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	124	DUF1279.					integral to membrane				breast(2)	2						TTGAATCGTTGATAAAGACTA	0.388													0	0	0	0.139131	0	59	70										C	13681707	G	C	13681707	3	2	38	1	0	0	0	0	1	0	0	0	1896	1299	45	1	460	1	C18orf19	18	13681707	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08		13681707	64395541	101	9385										
ALKBH7	84266	broad.mit.edu	37	chr19	6372969	6372969	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctgagcacggcagaggaggaGacgctgagccgagaactgga	17	9	0	5			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:6372969G>A	uc002meo.1	+	1	526	c.138G>A	c.(136-138)GAG>GAA	p.E46E		NM_032306	NP_115682	Q9BT30	ALKB7_HUMAN	spermatogenesis associated 11 precursor	46						extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CAGAGGAGGAGACGCTGAGCC	0.736													0	0	0	0.248553	0	7	2										A	6372969	G	A	6372969	2	1	38	1	0	0	0	0	0	0	0	1	532	933	33	1		1	ALKBH7	19	6372969	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08		6372969	52756014	102	9386										
MED26	9441	broad.mit.edu	37	chr19	16688392	16688392	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tgctggtgtgccggctcgatGagcttctgccagctccgcag	14	13	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:16688392G>T	uc002nen.1	-	3	510	c.249C>A	c.(247-249)CTC>CTA	p.L83L	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	83	TFIIS N-terminal.				regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						CCGGCTCGATGAGCTTCTGCC	0.672													1	0	2.32416e-17	0.249174	2.53693e-17	24	26										T	16688392	G	T	16688392	2	4	38	1	0	0	0	0	0	0	0	1	9444	1277	45	3		3	MED26	19	16688392	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	10315423	16688392	42440591	103	9387										
PDE4C	5143	broad.mit.edu	37	chr19	18327578	18327578	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	atgaccatcctgcgcagactCagtcgctgcttggcgctgag	12	13	1	3			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:18327578C>G	uc010xqc.1	-	12	1938	c.1458G>C	c.(1456-1458)CTG>CTC	p.L486L	PDE4C_uc002nik.3_Silent_p.L486L|PDE4C_uc002nil.3_Silent_p.L486L|PDE4C_uc002nif.3_Silent_p.L255L|PDE4C_uc002nig.3_Silent_p.L201L|PDE4C_uc002nih.3_Silent_p.L256L|PDE4C_uc010ebk.2_Silent_p.L380L|PDE4C_uc002nii.3_Silent_p.L454L|PDE4C_uc010ebl.2_Silent_p.L200L|PDE4C_uc010xqd.1_Silent_p.L255L	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	486					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	TGCGCAGACTCAGTCGCTGCT	0.617													0	0	0	0.257332	0	42	62										G	18327578	C	G	18327578	2	3	38	1	0	0	0	0	0	0	0	1	11641	813	29	1		1	PDE4C	19	18327578	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	1639186	18327578	40801405	104	9388										
HAPLN4	404037	broad.mit.edu	37	chr19	19371709	19371709	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cccgtagtcttgcagcgtgaCgttgcggaggaccagggagg	17	10	1	1	rs114536312	byFrequency	TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:19371709C>T	uc002nmb.2	-	3	452	c.397G>A	c.(397-399)GTC>ATC	p.V133I	HAPLN4_uc002nmc.2_Missense_Mutation_p.V133I	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	133	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			TGCAGCGTGACGTTGCGGAGG	0.652													0	0	0	0.294199	0	27	49										T	19371709	C	T	19371709	3	4	38	1	0	0	0	0	1	0	0	0	6957	536	19	2	823	2	HAPLN4	19	19371709	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	1044131	19371709	39757274	105	9389										
ANKRD27	84079	broad.mit.edu	37	chr19	33113450	33113450	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccagcgggcagcaatgtgtaGaggggtgtctcctttctcat	13	10	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:33113450G>C	uc002ntn.1	-	18	1861	c.1705C>G	c.(1705-1707)CTA>GTA	p.L569V		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	569	ANK 5.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GCAATGTGTAGAGGGGTGTCT	0.542													0	0	0	0.139131	0	67	84										C	33113450	G	C	33113450	3	2	38	1	0	0	0	0	1	0	0	0	655	933	33	1	1495	1	ANKRD27	19	33113450	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	13741741	33113450	26015533	106	9390										
ERCC2	2068	broad.mit.edu	37	chr19	45868143	45868143	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccagccctggcgccgccccaGggccttcaggtcatccaggt	12	18	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:45868143G>A	uc002pbj.2	-	7	594	c.547C>T	c.(547-549)CTG>TTG	p.L183L	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Intron|ERCC2_uc002pbk.2_Silent_p.L159L|ERCC2_uc002pbl.3_Silent_p.L159L|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	183	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CGCCGCCCCAGGGCCTTCAGG	0.632			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.219247	0	20	20										A	45868143	G	A	45868143	2	1	38	1	0	0	0	0	0	0	0	1	5213	991	35	2		2	ERCC2	19	45868143	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	12754693	45868143	13260840	107	9391										
HIF3A	64344	broad.mit.edu	37	chr19	46823770	46823770	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	actctcgcagacccattcagCggggcgccccctctcagaag	10	17	3	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:46823770C>A	uc002peh.2	+	9	1125	c.1096C>A	c.(1096-1098)CGG>AGG	p.R366R	HIF3A_uc002peg.3_Silent_p.R366R|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Silent_p.R310R|HIF3A_uc002pej.1_Silent_p.R297R|HIF3A_uc002pek.2_Silent_p.R310R|HIF3A_uc010xxy.1_Silent_p.R297R|HIF3A_uc002pel.2_Silent_p.R364R|HIF3A_uc010xxz.1_Silent_p.R315R	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		ACCCATTCAGCGGGGCGCCCC	0.657													1	0	5.20006e-24	0.301197	5.75721e-24	44	39										A	46823770	C	A	46823770	2	1	38	1	0	0	0	0	0	0	0	1	7105	759	27	4		4	HIF3A	19	46823770	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	955627	46823770	12305213	108	9392										
TULP2	7288	broad.mit.edu	37	chr19	49384274	49384274	+	Silent	SNP	G	G	A													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	tcaacagccagcttctaattGaaactggacaagcagatgct							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:49384274G>A	uc002pkz.2	-	13	1708	c.1557C>T	c.(1555-1557)TTC>TTT	p.F519F		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	519					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GCTTCTAATTGAAACTGGACA	0.512													0	0	0	0.134883	0	28	49										A	49384274	G	A	49384274	2	1	38	1	0	0	0	0	0	0	0	1	16771	1281	45	1		1	TULP2	19	49384274	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	2560504	49384274	9744709	109	9393	48	2								
TULP2	7288	broad.mit.edu	37	chr19	49384281	49384281	+	Missense_Mutation	SNP	G	G	A													0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccagcttctaattgaaactgGacaagcagatgctgaaggcc							TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr19:49384281G>A	uc002pkz.2	-	13	1701	c.1550C>T	c.(1549-1551)TCC>TTC	p.S517F		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	517					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ATTGAAACTGGACAAGCAGAT	0.517													0	0	0	0.173368	0	31	48										A	49384281	G	A	49384281	3	1	38	1	0	0	0	0	1	0	0	0	16771	1174	41	1	16	1	TULP2	19	49384281	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	7	49384281	9744702	110	9394	48	2								
TGM3	7053	broad.mit.edu	37	chr20	2312720	2312720	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	caacacgccatttgccgcgaCgtcttcaatgggtttggaaa	10	11	2	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr20:2312720C>T	uc002wfx.3	+	10	1503	c.1406C>T	c.(1405-1407)ACG>ATG	p.T469M		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	469					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	TTTGCCGCGACGTCTTCAATG	0.517													0	0	0	0.173368	0	35	37										T	2312720	C	T	2312720	3	4	38	1	0	0	0	0	1	0	0	0	15828	536	19	2	1444	2	TGM3	20	2312720	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		2312720	60712800	111	9395										
ASXL1	171023	broad.mit.edu	37	chr20	31021691	31021691	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ccgaaaagccacagcccactAaagaggagcccaaagtcccg	9	15	0	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr20:31021691A>T	uc002wxs.2	+	11	2116	c.1690A>T	c.(1690-1692)AAA>TAA	p.K564*	ASXL1_uc010geb.2_Nonsense_Mutation_p.K455*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	564					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						ACAGCCCACTAAAGAGGAGCC	0.527			F|N|Mis		MDS|CMML								0	0	0	0.139131	0	46	78										T	31021691	A	T	31021691	4	4	38	1	0	0	0	0	0	1	0	0	1066	363	13	5	1742	5	ASXL1	20	31021691	Nonsense_Mutation	SNP	A	TCGA-CU-A3QU-01A-11D-A22Z-08	28708971	31021691	32003829	112	9396										
SLC35C2	51006	broad.mit.edu	37	chr20	44979476	44979476	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	gcgaagcccagccagttcagGaggctgatctgatcgcccag	13	13	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr20:44979476G>T	uc002xro.2	-	9	1432	c.891C>A	c.(889-891)CTC>CTA	p.L297L	SLC35C2_uc002xrp.2_Silent_p.L276L|SLC35C2_uc002xrq.2_Silent_p.L297L|SLC35C2_uc002xrr.2_Silent_p.L297L|SLC35C2_uc010zxn.1_Silent_p.L162L|SLC35C2_uc010zxo.1_Silent_p.L183L|SLC35C2_uc010zxp.1_Silent_p.L326L	NM_173179	NP_775271	Q9NQQ7	S35C2_HUMAN	solute carrier family 35, member C2 isoform a	297	Helical; (Potential).				transport	integral to membrane				ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCCAGTTCAGGAGGCTGATCT	0.577													1	0	2.23348e-06	0.146539	2.29265e-06	16	67										T	44979476	G	T	44979476	2	4	38	1	0	0	0	0	0	0	0	1	14580	1161	41	3		3	SLC35C2	20	44979476	Silent	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	13957785	44979476	18046044	113	9397										
C21orf29	54084	broad.mit.edu	37	chr21	45945598	45945598	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cctcgaaggcctcccagtctCgggcgctgtgtgtggcaatg	14	13	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chr21:45945598C>T	uc002zfe.1	-	8	1340	c.1274G>A	c.(1273-1275)CGA>CAA	p.R425Q	C21orf29_uc010gpv.1_Missense_Mutation_p.R357Q	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	425	EAR 3.				cell adhesion	extracellular region	structural molecule activity				0						CTCCCAGTCTCGGGCGCTGTG	0.572													0	0	0	0.139131	0	54	87										T	45945598	C	T	45945598	3	4	38	1	0	0	0	0	1	0	0	0	2124	884	31	1	755	1	C21orf29	21	45945598	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		45945598	2184297	114	9398										
CSF2RA	1438	broad.mit.edu	37	chrX	1409371	1409371	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cgagaaattggcatccaattCtttgattcacttttggacac	7	9	2	2			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:1409371C>T	uc010nct.2	+	8	937	c.615C>T	c.(613-615)TTC>TTT	p.F205F	CSF2RA_uc011mhb.1_Silent_p.F205F|CSF2RA_uc004cpq.2_Silent_p.F205F|CSF2RA_uc004cpn.2_Silent_p.F205F|CSF2RA_uc004cpo.2_Silent_p.F205F|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.F72F|CSF2RA_uc004cpp.2_Silent_p.F205F|CSF2RA_uc010ncv.2_Silent_p.F205F|CSF2RA_uc004cpr.2_Silent_p.F205F	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	205	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GCATCCAATTCTTTGATTCAC	0.383													0	0	0	0.139131	0	129	179										T	1409371	C	T	1409371	2	4	38	1	0	0	0	0	0	0	0	1	3934	912	32	1		1	CSF2RA	23	1409371	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08		1409371	153861189	115	9399										
NHS	4810	broad.mit.edu	37	chrX	17744787	17744787	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	aaagccgaccccacctaaacGtagctcatcattgaggaagt	8	12	2	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:17744787G>A	uc004cxx.2	+	6	2836	c.2498G>A	c.(2497-2499)CGT>CAT	p.R833H	NHS_uc011mix.1_Missense_Mutation_p.R854H|NHS_uc004cxy.2_Missense_Mutation_p.R677H|NHS_uc004cxz.2_Missense_Mutation_p.R656H|NHS_uc004cya.2_Missense_Mutation_p.R556H	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	833						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCACCTAAACGTAGCTCATCA	0.488													0	0	0	0.139131	0	89	7										A	17744787	G	A	17744787	3	1	38	1	0	0	0	0	1	0	0	0	10411	1145	40	2	2625	2	NHS	23	17744787	Missense_Mutation	SNP	G	TCGA-CU-A3QU-01A-11D-A22Z-08	16335416	17744787	137525773	116	9400										
CCNB3	85417	broad.mit.edu	37	chrX	50089666	50089666	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	cataggagcacaactcacctCgtgtggatgactttgtgtac	10	10	1	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:50089666C>T	uc004dox.3	+	10	3968	c.3670C>T	c.(3670-3672)CGT>TGT	p.R1224C	CCNB3_uc004doy.2_Missense_Mutation_p.R1224C|CCNB3_uc004doz.2_Missense_Mutation_p.R120C|CCNB3_uc010njq.2_Missense_Mutation_p.R116C|CCNB3_uc004dpa.2_Missense_Mutation_p.R63C	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1224					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CAACTCACCTCGTGTGGATGA	0.463													0	0	0	0.139131	0	44	3										T	50089666	C	T	50089666	3	4	38	1	0	0	0	0	1	0	0	0	2914	884	31	1	3700	1	CCNB3	23	50089666	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	32344879	50089666	105180894	117	9401										
SLC16A2	6567	broad.mit.edu	37	chrX	73751256	73751256	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ggggctgtaatcctcttcttCgtccctctgatgcatcaaag	9	12	4	1			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:73751256C>T	uc004ebt.2	+	6	1876	c.1710C>T	c.(1708-1710)TTC>TTT	p.F570F	SLC16A2_uc010nlr.1_3'UTR	NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	496	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	TCCTCTTCTTCGTCCCTCTGA	0.532													0	0	0	0.139131	0	51	6										T	73751256	C	T	73751256	2	4	38	1	0	0	0	0	0	0	0	1	14408	883	31	1		1	SLC16A2	23	73751256	Silent	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	23661590	73751256	81519304	118	9402										
FLNA	2316	broad.mit.edu	37	chrX	153593318	153593318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.310344827586207	36	4.28181359752894e-10	3.06665192881618	4.1243628950051	2.63639662053595	0.118773630965533	0.241258937898739	24	ctcggtgcccaccttcacttCgaagggactgcaaatgcgag	11	13	1	0			TCGA-CU-A3QU-01A-11D-A22Z-08	TCGA-CU-A3QU-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d9be99ef-b43e-44f0-ace3-bac74f676897	fd78ed12-ff64-42ef-8f68-d13b2f707f73	g.chrX:153593318C>T	uc004fkk.2	-	12	1948	c.1699G>A	c.(1699-1701)GAA>AAA	p.E567K	FLNA_uc010nuu.1_Missense_Mutation_p.E567K	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	567	Filamin 3.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCTTCACTTCGAAGGGACTG	0.632													0	0	0	0.268233	0	42	42										T	153593318	C	T	153593318	3	4	38	1	0	0	0	0	1	0	0	0	5933	893	31	1	6392	1	FLNA	23	153593318	Missense_Mutation	SNP	C	TCGA-CU-A3QU-01A-11D-A22Z-08	79842062	153593318	1677242	119	9403										
AGRN	375790	broad.mit.edu	37	chr1	979601	979601	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tcggaggacgggccgtgtgtCtgtgacttcagctgccagag	16	10	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:979601C>G	uc001ack.1	+	11	2162	c.2112C>G	c.(2110-2112)GTC>GTG	p.V704V		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	704	Kazal-like 8.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGCCGTGTGTCTGTGACTTCA	0.706													0	0	0	0.01892	0	24	33										G	979601	C	G	979601	2	3	39	1	0	0	0	0	0	0	0	1	397	900	32	1		1	AGRN	1	979601	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		979601	248271020	1	9404										
CDK11A	728642	broad.mit.edu	37	chr1	1636040	1636040	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	caggctcttgaggtcgtgctCcacgtagttcatcacgatgt	11	11	3	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1636040C>T	uc009vks.2	-	14	1621	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Missense_Mutation_p.E12K|CDK11A_uc009vkp.2_Missense_Mutation_p.E122K|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Missense_Mutation_p.E495K|CDK11A_uc010nys.1_Missense_Mutation_p.E495K|CDK11A_uc010nyt.1_3'UTR	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	508	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						AGGTCGTGCTCCACGTAGTTC	0.617													0	0	0	0.004482	0	8	5										T	1636040	C	T	1636040	3	4	39	1	0	0	0	0	1	0	0	0	3126	864	30	1	857	1	CDK11A	1	1636040	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	656439	1636040	247614581	2	9405										
CDK11B	984	broad.mit.edu	37	chr1	1650892	1650892	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccaaagaatcatcttcttctCctctgaaataaaacacaaca	2	12	5	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1650892C>G	uc001agv.1	-	6	341	c.230G>C	c.(229-231)GGA>GCA	p.G77A	CDK11B_uc001ags.1_5'Flank|CDK11B_uc001agt.1_5'Flank|CDK11B_uc001aha.1_Missense_Mutation_p.G43A|CDK11B_uc001agw.1_Missense_Mutation_p.G43A|CDK11B_uc001agy.1_Missense_Mutation_p.G77A|CDK11B_uc001agx.1_Missense_Mutation_p.G77A|CDK11B_uc001agz.1_5'UTR|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_Missense_Mutation_p.G77A|CDK11A_uc009vks.2_Missense_Mutation_p.G77A|CDK11A_uc010nys.1_Missense_Mutation_p.G77A|CDK11A_uc010nyt.1_Missense_Mutation_p.G77A|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_Missense_Mutation_p.G77A|CDK11A_uc009vku.1_Missense_Mutation_p.G77A|CDK11A_uc009vkv.1_Missense_Mutation_p.G77A|CDK11A_uc001aht.1_Missense_Mutation_p.G77A|CDK11B_uc001ahu.1_Missense_Mutation_p.G77A|CDK11B_uc001ahv.1_Missense_Mutation_p.G77A|CDK11B_uc001ahw.1_Missense_Mutation_p.G77A	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	77					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						ATCTTCTTCTCCTCTGAAATA	0.388													0	0	0	0.00874	0	42	90										G	1650892	C	G	1650892	3	3	39	1	0	0	0	0	1	0	0	0	3127	855	30	1	2207	1	CDK11B	1	1650892	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	14852	1650892	247599729	3	9406										
ACTRT2	140625	broad.mit.edu	37	chr1	2938728	2938728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cgggcctggtggtggacagcGgggatgcggtcacctgcact	18	11	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:2938728G>A	uc001ajz.2	+	1	683	c.478G>A	c.(478-480)GGG>AGG	p.G160R		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	160						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GGTGGACAGCGGGGATGCGGT	0.642													0	0	0	0.009096	0	4	46										A	2938728	G	A	2938728	3	1	39	1	0	0	0	0	1	0	0	0	219	1116	39	2	480	2	ACTRT2	1	2938728	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1287836	2938728	246311893	4	9407										
TP73	7161	broad.mit.edu	37	chr1	3649318	3649318	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cggcctctcgcaggacctggGggccctgaagatccccgagc	14	16	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:3649318G>C	uc001akp.2	+	14	1696	c.1586G>C	c.(1585-1587)GGG>GCG	p.G529A	TP73_uc001akq.2_Intron|TP73_uc001akr.2_Missense_Mutation_p.G480A|TP73_uc009vlk.1_3'UTR|TP73_uc001aks.2_Missense_Mutation_p.G449R|TP73_uc010nzk.1_Missense_Mutation_p.G458A|TP73_uc010nzl.1_Missense_Mutation_p.G78A	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	529	SAM.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CAGGACCTGGGGGCCCTGAAG	0.706													0	0	0	0.004672	0	3	20										C	3649318	G	C	3649318	3	2	39	1	0	0	0	0	1	0	0	0	16390	1232	43	4	1679	4	TP73	1	3649318	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	710590	3649318	245601303	5	9408										
UQCRHL	440567	broad.mit.edu	37	chr1	16134162	16134162	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	catgtctggctacggttctaGatttaacacgagcagcaaca	9	10	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:16134162G>C	uc009vol.1	-	1	33	c.-17C>G	c.(-19--15)ATCTA>ATGTA			NM_001089591	NP_001083060			ubiquinol-cytochrome c reductase hinge												0						TACGGTTCTAGATTTAACACG	0.269													0	0	0	0.006214	0	10	20										C	16134162	G	C	16134162	1	2	39	1	0	0	0	0	0	0	0	0	17020	957	33	1		1	UQCRHL	1	16134162	Translation_Start_Site	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12484844	16134162	233116459	6	9409										
SLC30A2	7780	broad.mit.edu	37	chr1	26371526	26371526	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgaacaacaggcagatggcaGaggctacatacagctggcgc	13	10	0	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:26371526G>C	uc001blh.1	-	2	450	c.233C>G	c.(232-234)TCT>TGT	p.S78C	SLC30A2_uc001blg.1_Missense_Mutation_p.S78C	NM_032513	NP_115902	Q9BRI3	ZNT2_HUMAN	solute carrier family 30, member 2 isoform 2	78	Cytoplasmic (Potential).				positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGATGGCAGAGGCTACATA	0.527													0	0	0	0.00632	0	28	78										C	26371526	G	C	26371526	3	2	39	1	0	0	0	0	1	0	0	0	14555	942	33	1	913	1	SLC30A2	1	26371526	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	10237364	26371526	222879095	7	9410										
PHACTR4	65979	broad.mit.edu	37	chr1	28817511	28817511	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaaacgagaaattaaacgtcGgctcactagaaaggtactac	8	8	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:28817511G>C	uc001bpw.2	+	11	2147	c.1865G>C	c.(1864-1866)CGG>CCG	p.R622P	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.R606P|PHACTR4_uc001bpy.2_Missense_Mutation_p.R632P|PHACTR4_uc001bpz.2_5'Flank	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	622	RPEL 3.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		ATTAAACGTCGGCTCACTAGA	0.343													0	0	0	0.00308	0	8	25										C	28817511	G	C	28817511	3	2	39	1	0	0	0	0	1	0	0	0	11812	1116	39	4	1953	4	PHACTR4	1	28817511	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2445985	28817511	220433110	8	9411										
C1orf91	56063	broad.mit.edu	37	chr1	32687561	32687561	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggccggcggaggcccgcttCagcagcggctgcgtgccacc	16	16	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:32687561C>T	uc009vub.1	-	2	78	c.75G>A	c.(73-75)CTG>CTA	p.L25L	C1orf91_uc001buo.3_RNA|C1orf91_uc001bup.3_RNA|C1orf91_uc010oha.1_RNA|C1orf91_uc001buq.3_Silent_p.L25L|EIF3I_uc001bur.3_5'UTR|EIF3I_uc009vuc.2_5'Flank|EIF3I_uc001bus.2_5'Flank			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	25						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AGGCCCGCTTCAGCAGCGGCT	0.642													0	0	0	0.010729	0	11	25										T	32687561	C	T	32687561	2	4	39	1	0	0	0	0	0	0	0	1	2068	813	29	1		1	C1orf91	1	32687561	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3870050	32687561	216563060	9	9412										
KIAA0319L	79932	broad.mit.edu	37	chr1	35915552	35915552	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtgaaaagtgtaggttccctCaaccaggtttgaaagaaaaa	10	6	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:35915552C>T	uc001byx.2	-	15	2527	c.2269G>A	c.(2269-2271)GAG>AAG	p.E757K	KIAA0319L_uc001byw.2_Missense_Mutation_p.E199K|KIAA0319L_uc010ohv.1_Missense_Mutation_p.E399K	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	757	PKD 5.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TAGGTTCCCTCAACCAGGTTT	0.453													0	0	0	0.015359	0	35	43										T	35915552	C	T	35915552	3	4	39	1	0	0	0	0	1	0	0	0	8169	835	29	1	908	1	KIAA0319L	1	35915552	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3227991	35915552	213335069	10	9413										
HIVEP3	59269	broad.mit.edu	37	chr1	41990541	41990541	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acaaacatatttccctcggcCgcggcctcgcacatatacat	6	15	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:41990541C>T	uc001cgz.3	-	6	6461	c.5248G>A	c.(5248-5250)GGC>AGC	p.G1750S	HIVEP3_uc001cha.3_Missense_Mutation_p.G1750S|HIVEP3_uc001cgy.2_Intron	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1750					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TTCCCTCGGCCGCGGCCTCGC	0.502													0	0	0	0.00499	0	18	34										T	41990541	C	T	41990541	3	4	39	1	0	0	0	0	1	0	0	0	7188	652	23	2	1988	2	HIVEP3	1	41990541	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6074989	41990541	207260080	11	9414										
NEGR1	257194	broad.mit.edu	37	chr1	72400821	72400821	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gttgagtctgaacagaacacGtgtatgggccatcatctgtc	11	9	3	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:72400821G>A	uc001dfw.2	-	2	450	c.350C>T	c.(349-351)ACG>ATG	p.T117M	NEGR1_uc001dfv.2_Translation_Start_Site|NEGR1_uc010oqs.1_Missense_Mutation_p.T117M	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	117	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AACAGAACACGTGTATGGGCC	0.418													0	0	0	0.024245	0	16	26										A	72400821	G	A	72400821	3	1	39	1	0	0	0	0	1	0	0	0	10317	1145	40	2	738	2	NEGR1	1	72400821	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	30410280	72400821	176849800	12	9415										
TYW3	127253	broad.mit.edu	37	chr1	75204401	75204401	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctctgaagaaagcaaatggtGatgccactttgaaatttgaa	9	6	1	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:75204401G>A	uc001dgn.2	+	3	372	c.283G>A	c.(283-285)GAT>AAT	p.D95N	TYW3_uc010oqw.1_Intron|TYW3_uc010oqx.1_Intron|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	95					tRNA processing		methyltransferase activity			ovary(2)	2						AGCAAATGGTGATGCCACTTT	0.378													0	0	0	0.004482	0	9	16										A	75204401	G	A	75204401	3	1	39	1	0	0	0	0	1	0	0	0	16817	1290	45	1	293	1	TYW3	1	75204401	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2803580	75204401	174046220	13	9416										
GBP1	2633	broad.mit.edu	37	chr1	89528910	89528910	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggcctgtcatgtggatctctGatgccatgtccaggctgttc	12	11	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:89528910G>A	uc001dmx.2	-	2	228	c.8C>T	c.(7-9)TCA>TTA	p.S3L		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	3					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GTGGATCTCTGATGCCATGTC	0.453													0	0	0	0.00632	0	28	60										A	89528910	G	A	89528910	3	1	39	1	0	0	0	0	1	0	0	0	6273	1294	45	1	1810	1	GBP1	1	89528910	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	14324509	89528910	159721711	14	9417										
TRIM33	51592	broad.mit.edu	37	chr1	114940612	114940612	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aacttgaacaactttcatcaTctaaaaaggataccagagtc	5	9	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:114940612T>C	uc001eew.2	-	19	3205	c.3121A>G	c.(3121-3123)ATG>GTG	p.M1041V	TRIM33_uc010owr.1_Missense_Mutation_p.M655V|TRIM33_uc010ows.1_Missense_Mutation_p.M673V|TRIM33_uc001eex.2_Intron	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	1041	Bromo.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTTTCATCATCTAAAAAGGA	0.343			T	RET	papillary thyroid								0	0	0	0.010504	0	22	52										C	114940612	T	C	114940612	3	2	39	1	0	0	0	0	1	0	0	0	16504	1449	50	5	270	5	TRIM33	1	114940612	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	25411702	114940612	134310009	15	9418										
NGF	4803	broad.mit.edu	37	chr1	115829160	115829160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctgggtgctaaacagcacaCggggtgaacggagtcgccgc	16	11	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:115829160C>T	uc001efu.1	-	3	426	c.257G>A	c.(256-258)CGT>CAT	p.R86H		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	86					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	AAACAGCACACGGGGTGAACG	0.632													0	0	0	0.008291	0	11	30										T	115829160	C	T	115829160	3	4	39	1	0	0	0	0	1	0	0	0	10395	536	19	2	472	2	NGF	1	115829160	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	888548	115829160	133421461	16	9419										
NOTCH2	4853	broad.mit.edu	37	chr1	120462189	120462189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttcatcttcatcactcaaatCtgagctgcctcctcggagag	7	13	6	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:120462189C>G	uc001eik.2	-	31	5783	c.5527G>C	c.(5527-5529)GAT>CAT	p.D1843H		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1843	Cytoplasmic (Potential).|ANK 1.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACTCAAATCTGAGCTGCCT	0.498			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.00308	0	7	14										G	120462189	C	G	120462189	3	3	39	1	0	0	0	0	1	0	0	0	10548	913	32	1	1904	1	NOTCH2	1	120462189	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	4633029	120462189	128788432	17	9420										
RPTN	126638	broad.mit.edu	37	chr1	152127966	152127966	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctggccttgtctgtccatctGactgtagtgggaactctggc	12	11	3	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:152127966G>T	uc001ezs.1	-	3	1674	c.1609C>A	c.(1609-1611)CAG>AAG	p.Q537K		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	537	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CTGTCCATCTGACTGTAGTGG	0.532													1	0	4.53783e-81	0.01441	4.95855e-81	251	468										T	152127966	G	T	152127966	3	4	39	1	0	0	0	0	1	0	0	0	13664	1299	45	3	749	3	RPTN	1	152127966	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	31665777	152127966	97122655	18	9421										
OR6N2	81442	broad.mit.edu	37	chr1	158747279	158747279	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgcagagctgcatccagtcgGatgactgagaagatgagcat	13	8	0	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:158747279G>A	uc010pir.1	-	1	147	c.147C>T	c.(145-147)ATC>ATT	p.I49I		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					CATCCAGTCGGATGACTGAGA	0.483													0	0	0	0.01892	0	25	77										A	158747279	G	A	158747279	2	1	39	1	0	0	0	0	0	0	0	1	11207	1164	41	1		1	OR6N2	1	158747279	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	6619313	158747279	90503342	19	9422										
FCRLB	127943	broad.mit.edu	37	chr1	161697272	161697272	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gaacaatcggctggagccctGaaacccgacgtggaccttct	11	13	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:161697272G>A	uc001gbh.2	+	8	1335	c.1101G>A	c.(1099-1101)CTG>CTA	p.L367L	FCRLB_uc009wus.2_Silent_p.L367L|FCRLB_uc001gbj.2_Silent_p.*319*|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_Silent_p.*312*|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Silent_p.L367L|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	367						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CTGGAGCCCTGAAACCCGACG	0.682													0	0	0	0.00499	0	16	29										A	161697272	G	A	161697272	2	1	39	1	0	0	0	0	0	0	0	1	5801	1277	45	1		1	FCRLB	1	161697272	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2949993	161697272	87553349	20	9423										
MAEL	84944	broad.mit.edu	37	chr1	166959001	166959001	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gggaggaagaaaaggagaaaTacgcagaaatggctcgagaa	15	4	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:166959001T>C	uc001gdy.1	+	2	231	c.160T>C	c.(160-162)TAC>CAC	p.Y54H	MAEL_uc001gdz.1_Intron|MAEL_uc009wvf.1_5'Flank	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	54	HMG box.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						AAAGGAGAAATACGCAGAAAT	0.532													0	0	0	0.021553	0	5	8										C	166959001	T	C	166959001	3	2	39	1	0	0	0	0	1	0	0	0	9154	1406	49	5	166	5	MAEL	1	166959001	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	5261729	166959001	82291620	21	9424										
C1orf125	126859	broad.mit.edu	37	chr1	179399689	179399689	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaatggaagagtctacaagcGagacactgaaaattgttaag	10	5	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:179399689G>C	uc001gmo.2	+	14	1562	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.E267Q|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.E479Q	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	479	Potential.										0						GTCTACAAGCGAGACACTGAA	0.368													0	0	0	0.00499	0	18	47										C	179399689	G	C	179399689	3	2	39	1	0	0	0	0	1	0	0	0	1993	1059	37	1	1485	1	C1orf125	1	179399689	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12440688	179399689	69850932	22	9425										
LHX4	89884	broad.mit.edu	37	chr1	180243439	180243439	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acgggacaggacaatcctatCaggacttgagggatgggagc	15	8	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:180243439C>G	uc001goe.1	+	6	1121	c.898C>G	c.(898-900)CAG>GAG	p.Q300E	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	300						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ACAATCCTATCAGGACTTGAG	0.542													0	0	0	0.025465	0	40	81										G	180243439	C	G	180243439	3	3	39	1	0	0	0	0	1	0	0	0	8773	827	29	1	920	1	LHX4	1	180243439	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	843750	180243439	69007182	23	9426										
RGL1	23179	broad.mit.edu	37	chr1	183895257	183895257	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaacttgtgattccagactCagcaaatgtcttttatgcca	7	9	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:183895257C>T	uc001gqo.2	+	18	2295	c.2138C>T	c.(2137-2139)TCA>TTA	p.S713L	RGL1_uc001gqm.2_Missense_Mutation_p.S748L|RGL1_uc010pog.1_Missense_Mutation_p.S711L|RGL1_uc010poh.1_Missense_Mutation_p.S711L|RGL1_uc010poi.1_Missense_Mutation_p.S684L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	713	Ras-associating.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ATTCCAGACTCAGCAAATGTC	0.443													0	0	0	0.016723	0	14	47										T	183895257	C	T	183895257	3	4	39	1	0	0	0	0	1	0	0	0	13276	838	29	1	2313	1	RGL1	1	183895257	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3651818	183895257	65355364	24	9427										
PTGS2	5743	broad.mit.edu	37	chr1	186643532	186643532	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tagtactgtgggattgatatCatctagtccggagcgggaag	14	6	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:186643532C>T	uc001gsb.2	-	10	1905	c.1768G>A	c.(1768-1770)GAT>AAT	p.D590N	PTGS2_uc009wyo.2_Missense_Mutation_p.D437N	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	590					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GGATTGATATCATCTAGTCCG	0.368													0	0	0	0.01892	0	26	52										T	186643532	C	T	186643532	3	4	39	1	0	0	0	0	1	0	0	0	12756	826	29	1	50	1	PTGS2	1	186643532	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	2748275	186643532	62607089	25	9428										
FAM58B	339521	broad.mit.edu	37	chr1	200183226	200183226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tcactgcctgggccctgctgCgggacagctaccacgggggg	16	14	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:200183226C>T	uc009wzi.1	+	1	571	c.535C>T	c.(535-537)CGG>TGG	p.R179W		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	179					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					GGCCCTGCTGCGGGACAGCTA	0.637													0	0	0	0.006214	0	10	37										T	200183226	C	T	200183226	3	4	39	1	0	0	0	0	1	0	0	0	5591	759	27	2	537	2	FAM58B	1	200183226	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	13539694	200183226	49067395	26	9429										
ELF3	1999	broad.mit.edu	37	chr1	201980282	201980282	+	Frame_Shift_Del	DEL	G	G	-													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctcatggctgcaacctgtgaGattagcaacatttttagcaa							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:201980282delG	uc001gxg.3	+	1	3210	c.18delG	c.(16-18)GAGfs	p.E6fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.E6fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.E6fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	6					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CAACCTGTGAGATTAGCAACA	0.567																		23	22	---	---								-	201980282	G	-	201980282	7	5	39	1	0	1	0	1	0	0	0	0	5055	933	33	0	20	0	ELF3	1	201980282	Frame_Shift_Del	DEL	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1797056	201980282	47270339	27	9430										
SPATA17	128153	broad.mit.edu	37	chr1	217804728	217804728	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggccaagagaccatggccaCgttagcccggctgcaagcta	12	13	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:217804728C>G	uc001hlh.1	+	1	34	c.8C>G	c.(7-9)ACG>AGG	p.T3R	GPATCH2_uc001hlf.1_5'Flank|SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.T3R|GPATCH2_uc001hlg.3_5'Flank	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	3						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		ACCATGGCCACGTTAGCCCGG	0.527													0	0	0	0.014758	0	5	20										G	217804728	C	G	217804728	3	3	39	1	0	0	0	0	1	0	0	0	15001	536	19	4	10	4	SPATA17	1	217804728	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	15824446	217804728	31445893	28	9431										
PCNXL2	80003	broad.mit.edu	37	chr1	233363102	233363102	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaacatgacgaggcttccaGatcctgactcacatgctttt	8	11	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:233363102G>C	uc001hvl.2	-	10	2609	c.2374C>G	c.(2374-2376)CTG>GTG	p.L792V	PCNXL2_uc009xfu.2_Intron|PCNXL2_uc009xfv.1_Intron|PCNXL2_uc001hvq.1_Missense_Mutation_p.L91V	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	792						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GAGGCTTCCAGATCCTGACTC	0.343													0	0	0	0.020292	0	15	20										C	233363102	G	C	233363102	3	2	39	1	0	0	0	0	1	0	0	0	11592	933	33	1	4139	1	PCNXL2	1	233363102	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	15558374	233363102	15887519	29	9432										
OR2M7	391196	broad.mit.edu	37	chr1	248487244	248487244	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtgatgatgattgcaacaggGaaaacaagcattactataca	9	6	0	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:248487244G>A	uc010pzk.1	-	1	627	c.627C>T	c.(625-627)TTC>TTT	p.F209F		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCAACAGGGAAAACAAGCA	0.418													0	0	0	0.01441	0	87	201										A	248487244	G	A	248487244	2	1	39	1	0	0	0	0	0	0	0	1	11014	1165	41	1		1	OR2M7	1	248487244	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	15124142	248487244	763377	30	9433										
OR2T3	343173	broad.mit.edu	37	chr1	248637607	248637607	+	Frame_Shift_Del	DEL	A	A	-													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aagaatgaaccaagaaaagtAgtaaagggcaagcattgtcc							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:248637607delA	uc001iel.1	+	1	956	c.956delA	c.(955-957)TAGfs	p.*319fs		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	319					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAAGAAAAGTAGTAAAGGGCA	0.502																		38	185	---	---								-	248637607	A	-	248637607	7	5	39	1	0	1	0	1	0	0	0	0	11023	434	15	0	958	0	OR2T3	1	248637607	Frame_Shift_Del	DEL	A	TCGA-CU-A3YL-01A-11D-A22Z-08	150363	248637607	613014	31	9434										
OTOF	9381	broad.mit.edu	37	chr2	26739408	26739408	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tctcccaggaagtccccatcGtcccaggagcccactgtgcc	9	18	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:26739408G>A	uc002rhk.2	-	5	514	c.387C>T	c.(385-387)GAC>GAT	p.D129D	OTOF_uc010ylb.1_RNA	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	129	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTCCCCATCGTCCCAGGAGC	0.647													0	0	0	0.009096	0	4	50										A	26739408	G	A	26739408	2	1	39	1	0	0	0	0	0	0	0	1	11303	1136	40	2		2	OTOF	2	26739408	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		26739408	216459965	32	9435										
CCDC121	79635	broad.mit.edu	37	chr2	27850502	27850502	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaatagctgttccataccttCtcaggttgctctgtgtactc	7	11	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:27850502C>T	uc002rle.2	-	2	346	c.165G>A	c.(163-165)GAG>GAA	p.E55E	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Silent_p.E219E|CCDC121_uc002rld.2_Silent_p.E217E|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	55											0	Acute lymphoblastic leukemia(172;0.155)					TCCATACCTTCTCAGGTTGCT	0.408													0	0	0	0.01441	0	64	110										T	27850502	C	T	27850502	2	4	39	1	0	0	0	0	0	0	0	1	2757	912	32	1		1	CCDC121	2	27850502	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1111094	27850502	215348871	33	9436										
PPP1CB	5500	broad.mit.edu	37	chr2	29001877	29001877	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaccatgagtgtgctagcatCaatcgcatttatggattcta	8	8	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:29001877C>G	uc002rmg.2	+	4	547	c.387C>G	c.(385-387)ATC>ATG	p.I129M	PPP1CB_uc010ymj.1_Missense_Mutation_p.I101M|PPP1CB_uc010ymk.1_Missense_Mutation_p.I101M|PPP1CB_uc010yml.1_Missense_Mutation_p.I101M|PPP1CB_uc002rmh.2_Missense_Mutation_p.I129M	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	129					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTGCTAGCATCAATCGCATTT	0.328													0	0	0	0.020292	0	15	31										G	29001877	C	G	29001877	3	3	39	1	0	0	0	0	1	0	0	0	12350	816	29	1	397	1	PPP1CB	2	29001877	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1151375	29001877	214197496	34	9437										
VIT	5212	broad.mit.edu	37	chr2	36994239	36994239	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aattccattttcttacaggtGagaccacaaaagcctatcag	6	10	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:36994239G>T	uc002rpl.2	+	7	711	c.490G>T	c.(490-492)GAG>TAG	p.E164*	VIT_uc010ynf.1_Intron|VIT_uc002rpm.2_Nonsense_Mutation_p.E157*|VIT_uc010ezv.2_Nonsense_Mutation_p.E157*|VIT_uc010ezw.2_Nonsense_Mutation_p.E157*	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	164						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				TCTTACAGGTGAGACCACAAA	0.448													1	0	1.05317e-09	0.020292	1.11751e-09	13	12										T	36994239	G	T	36994239	4	4	39	1	0	0	0	0	0	1	0	0	17168	1291	45	3	637	3	VIT	2	36994239	Nonsense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	7992362	36994239	206205134	35	9438										
LHCGR	3973	broad.mit.edu	37	chr2	48915216	48915216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggtgaaatcggtgaagatgaGgattgccattttcttagcaa	12	5	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:48915216G>A	uc002rwu.3	-	11	1790	c.1720C>T	c.(1720-1722)CTC>TTC	p.L574F	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	574	Helical; Name=6; (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTGAAGATGAGGATTGCCATT	0.363									Familial_Male-Limited_Precocious_Puberty				0	0	0	0.025465	0	41	64										A	48915216	G	A	48915216	3	1	39	1	0	0	0	0	1	0	0	0	8762	1000	35	2	383	2	LHCGR	2	48915216	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	11920977	48915216	194284157	36	9439										
NRXN1	9378	broad.mit.edu	37	chr2	50724724	50724724	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	caggtcaatgtatgccattcCattaaatgtcaagctctgca	7	10	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:50724724C>A	uc010fbq.2	-	14	4223	c.2746G>T	c.(2746-2748)GGA>TGA	p.G916*	NRXN1_uc002rxb.3_Nonsense_Mutation_p.G548*|NRXN1_uc002rxe.3_Nonsense_Mutation_p.G876*|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	239	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TATGCCATTCCATTAAATGTC	0.438													1	0	0.00448238	0.004482	0.00455134	9	28										A	50724724	C	A	50724724	4	1	39	1	0	0	0	0	0	1	0	0	10665	603	21	4	2200	4	NRXN1	2	50724724	Nonsense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1809508	50724724	192474649	37	9440										
EFEMP1	2202	broad.mit.edu	37	chr2	56144869	56144869	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acggtgggaagggttggaggGaatgcgctgagggtcagctg	21	5	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:56144869G>A	uc002rzh.2	-	4	778	c.448C>T	c.(448-450)CCC>TCC	p.P150S	EFEMP1_uc002rzi.2_Missense_Mutation_p.P150S|EFEMP1_uc002rzj.2_Missense_Mutation_p.P150S|EFEMP1_uc010ypc.1_Missense_Mutation_p.P92S	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	150					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGTTGGAGGGAATGCGCTGA	0.527													0	0	0	0.013114	0	47	55										A	56144869	G	A	56144869	3	1	39	1	0	0	0	0	1	0	0	0	4941	1174	41	1	1065	1	EFEMP1	2	56144869	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5420145	56144869	187054504	38	9441										
PLEK	5341	broad.mit.edu	37	chr2	68607462	68607462	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttttggttgtcattacagggGagcgtgttcaatacgtggaa	13	5	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:68607462G>C	uc002sen.3	+	2	207	c.45G>C	c.(43-45)GGG>GGC	p.G15G	PLEK_uc010fde.2_Silent_p.G15G	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	15	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CATTACAGGGGAGCGTGTTCA	0.398													0	0	0	0.004482	0	9	25										C	68607462	G	C	68607462	2	2	39	1	0	0	0	0	0	0	0	1	12053	1161	41	1		1	PLEK	2	68607462	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12462593	68607462	174591911	39	9442										
ARHGAP25	9938	broad.mit.edu	37	chr2	69046289	69046289	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	caaagagtgatgactatgatGatcagagaccatgaagtcct	10	7	1	7			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:69046289G>C	uc002seu.2	+	9	1399	c.1035G>C	c.(1033-1035)ATG>ATC	p.M345I	ARHGAP25_uc010fdg.2_Missense_Mutation_p.M346I|ARHGAP25_uc010yql.1_Missense_Mutation_p.M306I|ARHGAP25_uc002sev.2_Missense_Mutation_p.M339I|ARHGAP25_uc002sew.2_Missense_Mutation_p.M338I|ARHGAP25_uc002sex.2_Missense_Mutation_p.M339I|ARHGAP25_uc002sey.2_Missense_Mutation_p.M72I	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	345	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TGACTATGATGATCAGAGACC	0.498													0	0	0	0.01441	0	54	95										C	69046289	G	C	69046289	3	2	39	1	0	0	0	0	1	0	0	0	874	1290	45	1	1112	1	ARHGAP25	2	69046289	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	438827	69046289	174153084	40	9443										
SMPD4	55627	broad.mit.edu	37	chr2	130910919	130910919	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cgccccaggggcgtaaggatGagtccgtcctcacccacgat	12	15	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:130910919G>A	uc002tqq.1	-	18	2635	c.2115C>T	c.(2113-2115)CTC>CTT	p.L705L	SMPD4_uc002tqo.1_Silent_p.L237L|SMPD4_uc002tqp.1_Silent_p.L444L|SMPD4_uc010yzy.1_Silent_p.L454L|SMPD4_uc010yzz.1_Silent_p.L369L|SMPD4_uc002tqr.1_Silent_p.L676L|SMPD4_uc002tqs.1_Silent_p.L573L|SMPD4_uc002tqt.1_Silent_p.L554L|SMPD4_uc010zaa.1_Silent_p.L563L|SMPD4_uc010zab.1_Silent_p.L603L|SMPD4_uc010zac.1_Silent_p.L446L|SMPD4_uc010zad.1_Silent_p.L341L	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	666					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GCGTAAGGATGAGTCCGTCCT	0.642													0	0	0	0.013537	0	13	28										A	130910919	G	A	130910919	2	1	39	1	0	0	0	0	0	0	0	1	14807	1277	45	1		1	SMPD4	2	130910919	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	61864630	130910919	112288454	41	9444										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135911282	135911282	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	attcaccccgggattatattGaagaggaggtgattgatgaa	12	5	1	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:135911282G>A	uc002tuj.2	+	19	2150	c.2125G>A	c.(2125-2127)GAA>AAA	p.E709K	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.E709K|RAB3GAP1_uc010fng.2_Missense_Mutation_p.E534K|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	709						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		GGATTATATTGAAGAGGAGGT	0.438													0	0	0	0.012319	0	22	48										A	135911282	G	A	135911282	3	1	39	1	0	0	0	0	1	0	0	0	12935	1291	45	1	2199	1	RAB3GAP1	2	135911282	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5000363	135911282	107288091	42	9445										
ARL6IP6	151188	broad.mit.edu	37	chr2	153575496	153575496	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctcgctgctcttcgccattCttctcgccttcctcctcgcc	6	20	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:153575496C>G	uc002tyn.2	+	1	1074	c.358C>G	c.(358-360)CTT>GTT	p.L120V	ARL6IP6_uc002tym.2_Intron|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_5'Flank|PRPF40A_uc010zcd.1_5'Flank|PRPF40A_uc002tyi.2_5'Flank|PRPF40A_uc002tyj.2_5'Flank|PRPF40A_uc002tyl.1_5'Flank	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	120	Helical; (Potential).					integral to membrane					0						CTTCGCCATTCTTCTCGCCTT	0.592													0	0	0	0.00499	0	15	41										G	153575496	C	G	153575496	3	3	39	1	0	0	0	0	1	0	0	0	945	913	32	1	360	1	ARL6IP6	2	153575496	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	17664214	153575496	89623877	43	9446										
GRB14	2888	broad.mit.edu	37	chr2	165404308	165404308	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agccctgctggtttcatcttCactgtatactttaatcacct	5	12	4	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:165404308C>T	uc002ucl.2	-	3	884	c.343G>A	c.(343-345)GAA>AAA	p.E115K	GRB14_uc010zcv.1_Missense_Mutation_p.E28K|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	115	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GTTTCATCTTCACTGTATACT	0.328													0	0	0	0.004482	0	9	24										T	165404308	C	T	165404308	3	4	39	1	0	0	0	0	1	0	0	0	6757	835	29	1	1327	1	GRB14	2	165404308	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	11828812	165404308	77795065	44	9447										
RAPGEF4	11069	broad.mit.edu	37	chr2	173891911	173891911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atgaaattcagttttgggtcGtcactgagatctgcctttgt	10	7	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:173891911G>A	uc002uhv.3	+	25	2669	c.2482G>A	c.(2482-2484)GTC>ATC	p.V828I	RAPGEF4_uc002uhw.3_Missense_Mutation_p.V684I	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	828	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GTTTTGGGTCGTCACTGAGAT	0.368													0	0	0	0.006122	0	18	37										A	173891911	G	A	173891911	3	1	39	1	0	0	0	0	1	0	0	0	13046	1145	40	2	2596	2	RAPGEF4	2	173891911	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	8487603	173891911	69307462	45	9448										
TTN	7273	broad.mit.edu	37	chr2	179455032	179455032	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aacatcaagttctacttctgGaggatgaaggatatcttttg	9	6	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:179455032G>A	uc010zfg.1	-	253	53940	c.53716C>T	c.(53716-53718)CCA>TCA	p.P17906S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P11601S|TTN_uc010zfi.1_Missense_Mutation_p.P11534S|TTN_uc010zfj.1_Missense_Mutation_p.P11409S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACTTCTGGAGGATGAAGG	0.428													0	0	0	0.00632	0	29	62										A	179455032	G	A	179455032	3	1	39	1	0	0	0	0	1	0	0	0	16732	1174	41	1	46795	1	TTN	2	179455032	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5563121	179455032	63744341	46	9449										
NCKAP1	10787	broad.mit.edu	37	chr2	183800087	183800087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccaattattgtcatcctcttCaagacactgtcaacagctaa	4	12	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:183800087C>G	uc002upc.2	-	25	3114	c.2712G>C	c.(2710-2712)TTG>TTC	p.L904F	NCKAP1_uc002upb.2_Missense_Mutation_p.L910F	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	904					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCATCCTCTTCAAGACACTGT	0.328													0	0	0	0.012319	0	22	31										G	183800087	C	G	183800087	3	3	39	1	0	0	0	0	1	0	0	0	10221	825	29	1	702	1	NCKAP1	2	183800087	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	4345055	183800087	59399286	47	9450										
ZNF804A	91752	broad.mit.edu	37	chr2	185803013	185803013	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttgaaaggaactttagacagTcacagcctaaatcctatctt	6	9	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:185803013T>C	uc002uph.2	+	4	3484	c.2890T>C	c.(2890-2892)TCA>CCA	p.S964P		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	964						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CTTTAGACAGTCACAGCCTAA	0.393													0	0	0	0.021523	0	26	65										C	185803013	T	C	185803013	3	2	39	1	0	0	0	0	1	0	0	0	18167	1667	58	5	2904	5	ZNF804A	2	185803013	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	2002926	185803013	57396360	48	9451										
PLCL1	5334	broad.mit.edu	37	chr2	198948687	198948687	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agctcttcgctgggaaccttCaaagaaagacctcgagaaag	10	10	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:198948687C>T	uc010fsp.2	+	2	737	c.446C>T	c.(445-447)TCA>TTA	p.S149L	PLCL1_uc002uuv.3_Missense_Mutation_p.S70L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	149	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TGGGAACCTTCAAAGAAAGAC	0.448													0	0	0	0.008871	0	19	40										T	198948687	C	T	198948687	3	4	39	1	0	0	0	0	1	0	0	0	12039	838	29	1	452	1	PLCL1	2	198948687	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	13145674	198948687	44250686	49	9452										
FAM126B	285172	broad.mit.edu	37	chr2	201873710	201873710	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cattaccggttctgtgcagtGaatgtttccctctgaggatg	11	9	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:201873710G>A	uc002uws.3	-	7	704	c.516C>T	c.(514-516)TTC>TTT	p.F172F	FAM126B_uc002uwu.2_Silent_p.F90F|FAM126B_uc002uwv.2_Silent_p.F172F|FAM126B_uc002uww.1_Silent_p.F172F	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	172						intracellular				ovary(1)	1						TCTGTGCAGTGAATGTTTCCC	0.299													0	0	0	0.020292	0	14	29										A	201873710	G	A	201873710	2	1	39	1	0	0	0	0	0	0	0	1	5430	1281	45	1		1	FAM126B	2	201873710	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2925023	201873710	41325663	50	9453										
GRM7	2917	broad.mit.edu	37	chr3	7503406	7503406	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggacagacgaacttcagctCaatgtgagttctgcttgctt	10	9	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:7503406C>G	uc003bqm.2	+	7	1786	c.1512C>G	c.(1510-1512)CTC>CTG	p.L504L	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.L504L|GRM7_uc003bql.2_Silent_p.L504L|GRM7_uc003bqn.1_Silent_p.L87L|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	504	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	AACTTCAGCTCAATGTGAGTT	0.443													0	0	0	0.008871	0	19	75										G	7503406	C	G	7503406	2	3	39	1	0	0	0	0	0	0	0	1	6802	813	29	1		1	GRM7	3	7503406	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		7503406	190519024	51	9454										
C3orf20	84077	broad.mit.edu	37	chr3	14745900	14745900	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctcctaccccatgatcttacGaaactacaaggcaaagatgc	6	13	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:14745900G>A	uc003byy.2	+	7	1339	c.935G>A	c.(934-936)CGA>CAA	p.R312Q	C3orf20_uc003byz.2_Missense_Mutation_p.R190Q|C3orf20_uc003bza.2_Missense_Mutation_p.R190Q|C3orf20_uc003byx.1_Intron	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	312						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						ATGATCTTACGAAACTACAAG	0.493													0	0	0	0.024334	0	27	76										A	14745900	G	A	14745900	3	1	39	1	0	0	0	0	1	0	0	0	2213	1058	37	1	953	1	C3orf20	3	14745900	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	7242494	14745900	183276530	52	9455										
TRIM71	131405	broad.mit.edu	37	chr3	32933231	32933231	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gggcagatggaccgcccttcCggcatcgccatcacccccga	11	18	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:32933231C>T	uc003cff.2	+	4	2598	c.2535C>T	c.(2533-2535)TCC>TCT	p.S845S		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	845	NHL 6.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						ACCGCCCTTCCGGCATCGCCA	0.527													0	0	0	0.008361	0	29	121										T	32933231	C	T	32933231	2	4	39	1	0	0	0	0	0	0	0	1	16541	639	23	2		2	TRIM71	3	32933231	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	18187331	32933231	165089199	53	9456										
FBXL2	25827	broad.mit.edu	37	chr3	33416785	33416785	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctgcttttcctcagcgtatCacggatgaaggtgtggtgca	13	9	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:33416785C>T	uc003cfp.2	+	10	734	c.663C>T	c.(661-663)ATC>ATT	p.I221I	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_Silent_p.I116I|FBXL2_uc011axp.1_Silent_p.I137I|FBXL2_uc011axq.1_RNA|FBXL2_uc011axr.1_RNA|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	221	LRR 7.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						CTCAGCGTATCACGGATGAAG	0.512													0	0	0	0.01441	0	48	35										T	33416785	C	T	33416785	2	4	39	1	0	0	0	0	0	0	0	1	5716	816	29	1		1	FBXL2	3	33416785	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	483554	33416785	164605645	54	9457										
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033161	37033161	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cttaaaatgtctctcaaattCtttttggagacgacagatca	6	8	4	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:37033161C>G	uc003cgk.2	-	1	1635	c.1408G>C	c.(1408-1410)GAA>CAA	p.E470Q	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	470						endoplasmic reticulum					0						CTCTCAAATTCTTTTTGGAGA	0.328													0	0	0	0.006214	0	10	38										G	37033161	C	G	37033161	3	3	39	1	0	0	0	0	1	0	0	0	5184	922	32	1	419	1	EPM2AIP1	3	37033161	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3616376	37033161	160989269	55	9458										
IMPDH2	3615	broad.mit.edu	37	chr3	49062587	49062587	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gccccaagggccaaggctttCgcaatatgacccacattttg	9	13	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:49062587C>T	uc003cvt.2	-	10	1214	c.1122G>A	c.(1120-1122)GCG>GCA	p.A374A		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	374					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCAAGGCTTTCGCAATATGAC	0.577													0	0	0	0.00632	0	30	23										T	49062587	C	T	49062587	2	4	39	1	0	0	0	0	0	0	0	1	7727	871	31	1		1	IMPDH2	3	49062587	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	12029426	49062587	148959843	56	9459										
OR5H2	79310	broad.mit.edu	37	chr3	98002110	98002110	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggcaacaatggcatatgatCgctatgtagccatatgcaaa	9	8	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:98002110C>T	uc003dsj.1	+	1	379	c.379C>T	c.(379-381)CGC>TGC	p.R127C		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GGCATATGATCGCTATGTAGC	0.378													0	0	0	0.007291	0	31	99										T	98002110	C	T	98002110	3	4	39	1	0	0	0	0	1	0	0	0	11162	884	31	1	381	1	OR5H2	3	98002110	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	48939523	98002110	100020320	57	9460										
BTLA	151888	broad.mit.edu	37	chr3	112190070	112190070	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaacccaccttggtgccttCtcaggcagcagaacaggcag	11	13	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:112190070C>G	uc003dza.3	-	3	739	c.536G>C	c.(535-537)AGA>ACA	p.R179T	BTLA_uc003dzb.3_Intron	NM_181780	NP_861445	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated isoform 1	179	Cytoplasmic (Potential).				T cell costimulation		receptor activity				0		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TTGGTGCCTTCTCAGGCAGCA	0.493													0	0	0	0.024245	0	15	47										G	112190070	C	G	112190070	3	3	39	1	0	0	0	0	1	0	0	0	1558	913	32	1	345	1	BTLA	3	112190070	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	14187960	112190070	85832360	58	9461										
GOLGB1	2804	broad.mit.edu	37	chr3	121396236	121396236	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgctgatctttatctgagaTagccataaggtactgttcct	8	9	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:121396236T>C	uc003eei.3	-	16	9046	c.8920A>G	c.(8920-8922)ATC>GTC	p.I2974V	GOLGB1_uc010hrc.2_Missense_Mutation_p.I2979V|GOLGB1_uc003eej.3_Missense_Mutation_p.I2940V	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2974	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTATCTGAGATAGCCATAAGG	0.408													0	0	0	0.020292	0	14	61										C	121396236	T	C	121396236	3	2	39	1	0	0	0	0	1	0	0	0	6565	1406	49	5	887	5	GOLGB1	3	121396236	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	9206166	121396236	76626194	59	9462										
PDIA5	10954	broad.mit.edu	37	chr3	122849434	122849434	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccagtttgtgaaggaacactCctctgtcctcgtcatgttcc	8	13	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:122849434C>T	uc003egc.1	+	11	937	c.881C>T	c.(880-882)TCC>TTC	p.S294F	PDIA5_uc003egd.1_Intron	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	294	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		AAGGAACACTCCTCTGTCCTC	0.587													0	0	0	0.01441	0	43	32										T	122849434	C	T	122849434	3	4	39	1	0	0	0	0	1	0	0	0	11671	855	30	1	923	1	PDIA5	3	122849434	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1453198	122849434	75172996	60	9463										
PLXNA1	5361	broad.mit.edu	37	chr3	126708282	126708282	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cacttcttcacgtccaagatCgtgcggctctgtgtggacga	11	12	3	1	rs146246704		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:126708282C>T	uc003ejg.2	+	1	781	c.777C>T	c.(775-777)ATC>ATT	p.I259I		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	282	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGTCCAAGATCGTGCGGCTCT	0.602													0	0	0	0.01441	0	50	138										T	126708282	C	T	126708282	2	4	39	1	0	0	0	0	0	0	0	1	12119	874	31	1		1	PLXNA1	3	126708282	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3858848	126708282	71314148	61	9464										
MECOM	2122	broad.mit.edu	37	chr3	168840502	168840502	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctcttcagtatgtgacagcaTgtgtttctccaggctgttaa	9	9	3	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:168840502T>G	uc003ffi.3	-	5	549	c.280A>C	c.(280-282)ATG>CTG	p.M94L	MECOM_uc010hwk.1_Missense_Mutation_p.M117L|MECOM_uc003ffj.3_Missense_Mutation_p.M158L|MECOM_uc011bpi.1_Missense_Mutation_p.M94L|MECOM_uc003ffn.3_Missense_Mutation_p.M94L|MECOM_uc003ffk.2_Missense_Mutation_p.M94L|MECOM_uc003ffl.2_Missense_Mutation_p.M254L|MECOM_uc011bpj.1_Missense_Mutation_p.M282L|MECOM_uc011bpk.1_Missense_Mutation_p.M84L|MECOM_uc010hwn.2_Missense_Mutation_p.M282L|MECOM_uc003ffm.1_Missense_Mutation_p.M158L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	94	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 2.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TGTGACAGCATGTGTTTCTCC	0.373													0	0	0	0.017118	0	36	27										G	168840502	T	G	168840502	3	3	39	1	0	0	0	0	1	0	0	0	9422	1464	51	5	2926	5	MECOM	3	168840502	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	42132220	168840502	29181928	62	9465										
HTRA3	94031	broad.mit.edu	37	chr4	8288376	8288376	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgatcatcaccaatgcccacGtggtgtccagcaacagtgct	9	13	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:8288376G>A	uc003gla.2	+	3	778	c.574G>A	c.(574-576)GTG>ATG	p.V192M	HTRA3_uc003gkz.2_Missense_Mutation_p.V192M	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	192	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						CAATGCCCACGTGGTGTCCAG	0.602													0	0	0	0.024334	0	28	34										A	8288376	G	A	8288376	3	1	39	1	0	0	0	0	1	0	0	0	7455	1145	40	2	584	2	HTRA3	4	8288376	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		8288376	182865900	63	9466										
BEND4	389206	broad.mit.edu	37	chr4	42145579	42145579	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cctcttctggcagtgtagatGaagatgggtggccatgggat	15	7	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:42145579G>A	uc003gwn.2	-	3	1500	c.920C>T	c.(919-921)TCA>TTA	p.S307L	BEND4_uc003gwm.2_Missense_Mutation_p.S307L|BEND4_uc011byy.1_Missense_Mutation_p.S307L	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	307											0						CAGTGTAGATGAAGATGGGTG	0.463													0	0	0	0.009096	0	4	3										A	42145579	G	A	42145579	3	1	39	1	0	0	0	0	1	0	0	0	1400	1294	45	1	700	1	BEND4	4	42145579	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	33857203	42145579	149008697	64	9467										
TMEM165	55858	broad.mit.edu	37	chr4	56284049	56284049	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agtacctcagaaaaagtggtTgcattttatttcacccattt	6	8	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:56284049T>A	uc003hax.2	+	4	956	c.689T>A	c.(688-690)TTG>TAG	p.L230*	TMEM165_uc011bzy.1_Nonsense_Mutation_p.L167*	NM_018475	NP_060945	Q9HC07	TM165_HUMAN	transmembrane protein 165	230	Helical; (Potential).					integral to membrane					0	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			AAAAAGTGGTTGCATTTTATT	0.353													0	0	0	0.004672	0	3	27										A	56284049	T	A	56284049	4	1	39	1	0	0	0	0	0	1	0	0	16077	1821	63	5	703	5	TMEM165	4	56284049	Nonsense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	14138470	56284049	134870227	65	9468										
METTL14	57721	broad.mit.edu	37	chr4	119613186	119613186	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tactgccaacattttgtagaCactggacatagacctcagaa	7	10	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:119613186C>A	uc003icf.2	+	5	491	c.375C>A	c.(373-375)GAC>GAA	p.D125E	METTL14_uc003icg.2_Missense_Mutation_p.D87E	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	125						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						ATTTTGTAGACACTGGACATA	0.353													1	0	1.96895e-08	0.016522	2.06928e-08	22	59										A	119613186	C	A	119613186	3	1	39	1	0	0	0	0	1	0	0	0	9498	477	17	4	393	4	METTL14	4	119613186	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	63329137	119613186	71541090	66	9469										
CLGN	1047	broad.mit.edu	37	chr4	141310427	141310427	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgactttatcggcccatctCcagatcctgtgctctcatct	6	15	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:141310427C>T	uc011chi.1	-	16	2002	c.1784G>A	c.(1783-1785)GGA>GAA	p.G595E	CLGN_uc003iii.2_Missense_Mutation_p.G595E	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	595	Cytoplasmic (Potential).				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					CGGCCCATCTCCAGATCCTGT	0.333													0	0	0	0.006214	0	10	50										T	141310427	C	T	141310427	3	4	39	1	0	0	0	0	1	0	0	0	3524	855	30	1	52	1	CLGN	4	141310427	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	21697241	141310427	49843849	67	9470										
LRBA	987	broad.mit.edu	37	chr4	151773605	151773605	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tctctgaggcatcctcttctGaaggagaacttatagaagca	9	9	3	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:151773605G>A	uc010ipj.2	-	23	3731	c.3257C>T	c.(3256-3258)TCA>TTA	p.S1086L	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Missense_Mutation_p.S1086L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1086						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					ATCCTCTTCTGAAGGAGAACT	0.383													0	0	0	0.013537	0	13	51										A	151773605	G	A	151773605	3	1	39	1	0	0	0	0	1	0	0	0	8931	1294	45	1	5478	1	LRBA	4	151773605	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	10463178	151773605	39380671	68	9471										
FAT1	2195	broad.mit.edu	37	chr4	187539870	187539870	+	Frame_Shift_Del	DEL	C	C	-													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtcggcattggagccctcatCggcatcacttgcaagaactt							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:187539870delC	uc003izf.2	-	10	8058	c.7870delG	c.(7870-7872)GATfs	p.D2624fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2624	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAGCCCTCATCGGCATCACTT	0.443										HNSCC(5;0.00058)								11	29	---	---								-	187539870	C	-	187539870	7	5	39	1	0	1	0	1	0	0	0	0	5689	884	31	0	5968	0	FAT1	4	187539870	Frame_Shift_Del	DEL	C	TCGA-CU-A3YL-01A-11D-A22Z-08	35766265	187539870	3614406	69	9472										
SDHA	6389	broad.mit.edu	37	chr5	224526	224527	+	Missense_Mutation	DNP	GG	GG	TT													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aatttgatgcagtggtggtaGgcgctggaggggcaggcttg							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:224526_224527GG>TT	uc003jao.3	+	3	317_318	c.202_203GG>TT	c.(202-204)GGC>TTC	p.G68F	SDHA_uc003jan.2_Missense_Mutation_p.G68F|SDHA_uc011clv.1_Missense_Mutation_p.G68F|SDHA_uc011clw.1_Missense_Mutation_p.G68F|SDHA_uc003jap.3_Missense_Mutation_p.G68F	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	68	FAD (By similarity).				nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	AGTGGTGGTAGGCGCTGGAGGG	0.47									Familial_Paragangliomas				0	0	0	0.004672	0	50	78										TT	224527	GG	TT	224526	3	4	39	1	0	0	0	0	1	0	0	0	13963	1000	35	4	212	4	SDHA	5	224526	Missense_Mutation	DNP	GG	TCGA-CU-A3YL-01A-11D-A22Z-08		224526	180690734	70	9473										
TRIO	7204	broad.mit.edu	37	chr5	14358313	14358313	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acgtggctggaggagctgcaGaaggagctgctggacgacgt	18	8	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:14358313G>A	uc003jff.2	+	12	2079	c.2073G>A	c.(2071-2073)CAG>CAA	p.Q691Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.Q642Q|TRIO_uc003jfh.1_Silent_p.Q340Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	691					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGGAGCTGCAGAAGGAGCTGC	0.687													0	0	0	0.00308	0	8	17										A	14358313	G	A	14358313	2	1	39	1	0	0	0	0	0	0	0	1	16549	933	33	1		1	TRIO	5	14358313	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	14133787	14358313	166556947	71	9474										
BASP1	10409	broad.mit.edu	37	chr5	17275374	17275374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agggctacaatgtgaacgacGagaaagccaaggagaaagac	13	7	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:17275374G>A	uc003jfx.2	+	2	228	c.49G>A	c.(49-51)GAG>AAG	p.E17K		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	17					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						TGTGAACGACGAGAAAGCCAA	0.577													0	0	0	0.00308	0	7	15										A	17275374	G	A	17275374	3	1	39	1	0	0	0	0	1	0	0	0	1317	1059	37	1	51	1	BASP1	5	17275374	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2917061	17275374	163639886	72	9475										
C5orf42	65250	broad.mit.edu	37	chr5	37154070	37154070	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gactttgtgctctgtcctttGaatcggaactctggttttgg	11	8	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:37154070G>C	uc011cpa.1	-	41	8214	c.7983C>G	c.(7981-7983)TTC>TTG	p.F2661L	C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Missense_Mutation_p.F1179L|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.F1754L	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2661										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TCTGTCCTTTGAATCGGAACT	0.393													0	0	0	0.012319	0	22	27										C	37154070	G	C	37154070	3	2	39	1	0	0	0	0	1	0	0	0	2301	1281	45	1	1658	1	C5orf42	5	37154070	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	19878696	37154070	143761190	73	9476										
MAST4	375449	broad.mit.edu	37	chr5	66460281	66460281	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gccgtctcttttgttcccctCaaggccttaacaggccgggt	10	14	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:66460281C>G	uc003jut.1	+	28	4775	c.4707C>G	c.(4705-4707)CTC>CTG	p.L1569L	MAST4_uc003juw.2_Silent_p.L1497L|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1761						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TTGTTCCCCTCAAGGCCTTAA	0.607													0	0	0	0.024245	0	15	35										G	66460281	C	G	66460281	2	3	39	1	0	0	0	0	0	0	0	1	9327	813	29	1		1	MAST4	5	66460281	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	29306211	66460281	114454979	74	9477										
OCLN	4950	broad.mit.edu	37	chr5	68805528	68805528	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gaacccaactgctcagtcttCtggatctctatatggttcac	7	12	5	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:68805528C>G	uc003jwu.2	+	3	1047	c.611C>G	c.(610-612)TCT>TGT	p.S204C	OCLN_uc003jwv.3_Missense_Mutation_p.S204C	NM_002538	NP_002529			occludin												0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GCTCAGTCTTCTGGATCTCTA	0.403													0	0	0	0.01441	0	64	115										G	68805528	C	G	68805528	3	3	39	1	0	0	0	0	1	0	0	0	10820	913	32	1	617	1	OCLN	5	68805528	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	2345247	68805528	112109732	75	9478										
WDR41	55255	broad.mit.edu	37	chr5	76732192	76732192	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggctggcttgtttgctgactCttccaaatccccacatgtta	8	12	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:76732192C>A	uc003kff.1	-	12	1408	c.1121G>T	c.(1120-1122)AGA>ATA	p.R374I	WDR41_uc011csy.1_Missense_Mutation_p.R316I|WDR41_uc011csz.1_Missense_Mutation_p.R319I	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	374											0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		TTTGCTGACTCTTCCAAATCC	0.353													1	0	9.16793e-09	0.00499	9.66587e-09	17	36										A	76732192	C	A	76732192	3	1	39	1	0	0	0	0	1	0	0	0	17291	913	32	3	266	3	WDR41	5	76732192	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	7926664	76732192	104183068	76	9479										
TSLP	85480	broad.mit.edu	37	chr5	110407681	110407681	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctggtgttaacttacgacttCactaactgtgactttgagaa	8	8	1	2	rs148498768	byFrequency	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:110407681C>T	uc003kpb.2	+	1	292	c.93C>T	c.(91-93)TTC>TTT	p.F31F	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_5'Flank	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	31						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		CTTACGACTTCACTAACTGTG	0.368													0	0	0	0.027894	0	40	44										T	110407681	C	T	110407681	2	4	39	1	0	0	0	0	0	0	0	1	16625	825	29	1		1	TSLP	5	110407681	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	33675489	110407681	70507579	77	9480										
STARD4	134429	broad.mit.edu	37	chr5	110835670	110835670	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agactgaggaatcatcccacGcagatctgtctgaatatatc	8	10	3	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:110835670G>T	uc003kph.1	-	6	616	c.532C>A	c.(532-534)CGT>AGT	p.R178S	STARD4_uc010jbw.1_Missense_Mutation_p.R80S|STARD4_uc010jbx.1_Missense_Mutation_p.R80S|STARD4_uc003kpi.1_RNA	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	178	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		ATCATCCCACGCAGATCTGTC	0.413													1	0	7.92952e-12	0.021523	8.52359e-12	26	43										T	110835670	G	T	110835670	3	4	39	1	0	0	0	0	1	0	0	0	15258	1087	38	4	89	4	STARD4	5	110835670	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	427989	110835670	70079590	78	9481										
SNCAIP	9627	broad.mit.edu	37	chr5	121759024	121759024	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cctgctctacaggaagttctGagagctcatcatccaacatg	8	12	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:121759024G>A	uc003ksw.1	+	4	798	c.592G>A	c.(592-594)GAG>AAG	p.E198K	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.E198K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E245K|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.E198K	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	198					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AGGAAGTTCTGAGAGCTCATC	0.463													0	0	0	0.012213	0	33	61										A	121759024	G	A	121759024	3	1	39	1	0	0	0	0	1	0	0	0	14841	1291	45	1	602	1	SNCAIP	5	121759024	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	10923354	121759024	59156236	79	9482										
FBN2	2201	broad.mit.edu	37	chr5	127614405	127614405	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tccaggaagtgggcaaagctCgcactggtggccccagcctc	13	14	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:127614405C>G	uc003kuu.2	-	57	7706	c.7267G>C	c.(7267-7269)GAG>CAG	p.E2423Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2423	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGGCAAAGCTCGCACTGGTGG	0.493													0	0	0	0.006122	0	19	46										G	127614405	C	G	127614405	3	3	39	1	0	0	0	0	1	0	0	0	5703	893	31	1	1507	1	FBN2	5	127614405	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	5855381	127614405	53300855	80	9483										
PCDHB1	29930	broad.mit.edu	37	chr5	140433360	140433360	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcactggtaatagtgagtttCgctttcttaagcgttttatg	10	6	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:140433360C>G	uc003lik.1	+	1	2382	c.2305C>G	c.(2305-2307)CGC>GGC	p.R769G		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	769	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGTGAGTTTCGCTTTCTTAA	0.463													0	0	0	0.007291	0	29	66										G	140433360	C	G	140433360	3	3	39	1	0	0	0	0	1	0	0	0	11534	884	31	1	2307	1	PCDHB1	5	140433360	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	12818955	140433360	40481900	81	9484										
PCDHB6	56130	broad.mit.edu	37	chr5	140530412	140530412	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcgaaggcaggaagttcccgGagctggtgctagacaaaccg	15	10	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:140530412G>C	uc003lir.2	+	1	574	c.574G>C	c.(574-576)GAG>CAG	p.E192Q	PCDHB6_uc011dah.1_Missense_Mutation_p.E56Q	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	192	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGTTCCCGGAGCTGGTGCT	0.617													0	0	0	0.00874	0	43	62										C	140530412	G	C	140530412	3	2	39	1	0	0	0	0	1	0	0	0	11546	1175	41	1	576	1	PCDHB6	5	140530412	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	97052	140530412	40384848	82	9485										
GABRG2	2566	broad.mit.edu	37	chr5	161528316	161528316	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cactcctgccccttggagttCtccagttgtaagtaatattc	7	12	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:161528316C>T	uc003lyz.3	+	5	982	c.624C>T	c.(622-624)TTC>TTT	p.F208F	GABRG2_uc010jjc.2_Silent_p.F208F|GABRG2_uc003lyy.3_Silent_p.F208F|GABRG2_uc011dej.1_Silent_p.F113F	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	208	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCTTGGAGTTCTCCAGTTGTA	0.363													0	0	0	0.013537	0	10	11										T	161528316	C	T	161528316	2	4	39	1	0	0	0	0	0	0	0	1	6172	912	32	1		1	GABRG2	5	161528316	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	20997904	161528316	19386944	83	9486										
UNC5A	90249	broad.mit.edu	37	chr5	176306326	176306326	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tccaggacacaaggtttgctGagctgctggctctggagagt	14	9	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:176306326G>C	uc003mey.2	+	14	2392	c.2200G>C	c.(2200-2202)GAG>CAG	p.E734Q		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	734	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGGTTTGCTGAGCTGCTGGC	0.617													0	0	0	0.024334	0	25	60										C	176306326	G	C	176306326	3	2	39	1	0	0	0	0	1	0	0	0	16988	1291	45	1	2254	1	UNC5A	5	176306326	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	14778010	176306326	4608934	84	9487										
FLT4	2324	broad.mit.edu	37	chr5	180041110	180041110	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aagcaccccaaaggaccacaCgtcactctgcgtggtgtaca	9	14	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:180041110C>T	uc003mma.3	-	24	3368	c.3289G>A	c.(3289-3291)GTG>ATG	p.V1097M	FLT4_uc003mlz.3_Missense_Mutation_p.V1097M	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1097	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AAGGACCACACGTCACTCTGC	0.622									Congenital_Hereditary_Lymphedema				0	0	0	0.00499	0	15	36										T	180041110	C	T	180041110	3	4	39	1	0	0	0	0	1	0	0	0	5944	536	19	2	838	2	FLT4	5	180041110	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3734784	180041110	874150	85	9488										
FOXQ1	94234	broad.mit.edu	37	chr6	1313536	1313537	+	Frame_Shift_Ins	INS	-	-	A													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	actggatgctcaaccccaacINSagcgagtacaccttcgccga							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:1313536_1313537insA	uc003mtl.3	+	1	862_863	c.597_598insA	c.(595-600)AACAGCfs	p.N199fs		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	199_200	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TCAACCCCAACAGCGAGTACAC	0.515																		23	7	---	---								A	1313537	-	A	1313536	7	5	39	1	0	1	1	0	0	0	0	0	6030	477	17	0	599	0	FOXQ1	6	1313536	Frame_Shift_Ins	INS	-	TCGA-CU-A3YL-01A-11D-A22Z-08		1313536	169801531	86	9489										
SERPINB6	5269	broad.mit.edu	37	chr6	2948867	2948867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cgggagggacacttccacctCctcttcatccatcatgtcca	7	16	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:2948867C>T	uc003muk.2	-	6	2791	c.796G>A	c.(796-798)GAG>AAG	p.E266K	SERPINB6_uc003mui.2_Missense_Mutation_p.E149K|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.E266K|SERPINB6_uc003mum.2_Missense_Mutation_p.E266K|SERPINB6_uc003mun.2_Missense_Mutation_p.E266K|SERPINB6_uc003muo.2_Missense_Mutation_p.E266K	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	266					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	ACTTCCACCTCCTCTTCATCC	0.517													0	0	0	0.01441	0	56	122										T	2948867	C	T	2948867	3	4	39	1	0	0	0	0	1	0	0	0	14105	864	30	1	338	1	SERPINB6	6	2948867	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1635331	2948867	168166200	87	9490										
DSP	1832	broad.mit.edu	37	chr6	7575714	7575714	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaaggatagataaacagatcGactttaggtatgccagcctc	9	8	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:7575714G>C	uc003mxp.1	+	18	2902	c.2623G>C	c.(2623-2625)GAC>CAC	p.D875H	DSP_uc003mxq.1_Missense_Mutation_p.D875H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	875	Globular 1.|Spectrin 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TAAACAGATCGACTTTAGGTA	0.473													0	0	0	0.016723	0	13	34										C	7575714	G	C	7575714	3	2	39	1	0	0	0	0	1	0	0	0	4781	1058	37	1	2693	1	DSP	6	7575714	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4626847	7575714	163539353	88	9491										
HIST1H1C	3006	broad.mit.edu	37	chr6	26056108	26056108	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcagcacttttggcagctttCttgggcttcgcaaccttggc	11	12	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:26056108C>G	uc003nfw.2	-	1	592	c.549G>C	c.(547-549)AAG>AAC	p.K183N		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	183					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TGGCAGCTTTCTTGGGCTTCG	0.552													0	0	0	0.007291	0	30	52										G	26056108	C	G	26056108	3	3	39	1	0	0	0	0	1	0	0	0	7124	912	32	1	96	1	HIST1H1C	6	26056108	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	18480394	26056108	145058959	89	9492										
TRIM31	11074	broad.mit.edu	37	chr6	30080495	30080495	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcagaaattgtgcccacagtCgatggtgacaggtttctgca	12	9	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:30080495C>T	uc003npg.1	-	2	198	c.88G>A	c.(88-90)GAC>AAC	p.D30N	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	30	RING-type.					mitochondrion	ligase activity|zinc ion binding			lung(1)	1						TGCCCACAGTCGATGGTGACA	0.473													0	0	0	0.024334	0	27	57										T	30080495	C	T	30080495	3	4	39	1	0	0	0	0	1	0	0	0	16502	884	31	1	1221	1	TRIM31	6	30080495	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	4024387	30080495	141034572	90	9493										
VARS2	57176	broad.mit.edu	37	chr6	30891140	30891140	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgcctgcagctgtctccctCctccccgatggatgcctgga	10	17	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:30891140C>A	uc003nsc.1	+	24	2956	c.2324C>A	c.(2323-2325)TCC>TAC	p.S775Y	VARS2_uc011dmx.1_Missense_Mutation_p.S775Y|VARS2_uc011dmy.1_Missense_Mutation_p.S635Y|VARS2_uc011dmz.1_Missense_Mutation_p.S805Y|VARS2_uc011dna.1_Missense_Mutation_p.S773Y|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Missense_Mutation_p.S213Y|VARS2_uc010jsg.1_Missense_Mutation_p.S147Y|VARS2_uc010jsh.1_5'UTR	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	775					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CTGTCTCCCTCCTCCCCGATG	0.657													1	0	1.08611e-07	0.010729	1.13783e-07	12	30										A	30891140	C	A	30891140	3	1	39	1	0	0	0	0	1	0	0	0	17121	855	30	3	2512	3	VARS2	6	30891140	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	810645	30891140	140223927	91	9494										
DNAH8	1769	broad.mit.edu	37	chr6	38941567	38941567	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aactacggagccccatgatcGatttccaattacattgcttc	6	12	0	1	rs144808884	byFrequency	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:38941567G>A	uc003ooe.1	+	82	12605	c.12005G>A	c.(12004-12006)CGA>CAA	p.R4002Q	DNAH8_uc003oog.1_Missense_Mutation_p.R451Q	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCCCATGATCGATTTCCAATT	0.393													0	0	0	0.016723	0	12	24										A	38941567	G	A	38941567	3	1	39	1	0	0	0	0	1	0	0	0	4607	1058	37	1	12323	1	DNAH8	6	38941567	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	8050427	38941567	132173500	92	9495										
SLC22A7	10864	broad.mit.edu	37	chr6	43266487	43266487	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tctcctctaccattgcaactGaggtacttaagcccagaagt	7	12	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:43266487G>C	uc003out.2	+	1	490	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	SLC22A7_uc010jyl.1_Missense_Mutation_p.E131Q|SLC22A7_uc003ous.2_Missense_Mutation_p.E131Q	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	131						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CATTGCAACTGAGGTACTTAA	0.468													0	0	0	0.010729	0	10	24										C	43266487	G	C	43266487	3	2	39	1	0	0	0	0	1	0	0	0	14459	1291	45	1	393	1	SLC22A7	6	43266487	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4324920	43266487	127848580	93	9496										
GRIK2	2898	broad.mit.edu	37	chr6	102516372	102516372	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acagaaggttgccaggtaaaGaaaccatggcataaagctgg	12	7	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:102516372G>C	uc003pqp.3	+	16	2962	c.2713G>C	c.(2713-2715)GAA>CAA	p.E905Q	GRIK2_uc003pqo.3_3'UTR|GRIK2_uc010kcw.2_3'UTR	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	905	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GCCAGGTAAAGAAACCATGGC	0.433													0	0	0	0.006214	0	9	25										C	102516372	G	C	102516372	3	2	39	1	0	0	0	0	1	0	0	0	6774	943	33	1	2948	1	GRIK2	6	102516372	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	59249885	102516372	68598695	94	9497										
TPD52L1	7164	broad.mit.edu	37	chr6	125578274	125578274	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	actttcaaatcatttgaggaGagggttgagacaactgtcac	10	7	3	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:125578274G>A	uc003pzu.1	+	6	675	c.456G>A	c.(454-456)GAG>GAA	p.E152E	TPD52L1_uc003pzv.1_Intron|TPD52L1_uc003pzw.1_Intron|TPD52L1_uc003pzy.1_Silent_p.E123E|TPD52L1_uc003pzz.1_Intron	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1	152					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		CATTTGAGGAGAGGGTTGAGA	0.443													0	0	0	0.004482	0	8	23										A	125578274	G	A	125578274	2	1	39	1	0	0	0	0	0	0	0	1	16395	933	33	1		1	TPD52L1	6	125578274	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	23061902	125578274	45536793	95	9498										
CCDC28A	25901	broad.mit.edu	37	chr6	139106381	139106381	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaggaaatgaatgttccattGaacagatggaacatgttcgg	11	5	0	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:139106381G>A	uc003qie.2	+	4	765	c.610G>A	c.(610-612)GAA>AAA	p.E204K		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	204											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		ATGTTCCATTGAACAGATGGA	0.393													0	0	0	0.012213	0	34	42										A	139106381	G	A	139106381	3	1	39	1	0	0	0	0	1	0	0	0	2802	1291	45	1	624	1	CCDC28A	6	139106381	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	13528107	139106381	32008686	96	9499										
STX11	8676	broad.mit.edu	37	chr6	144508056	144508056	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggccatcaaggcccggggcGaggtcatccactgcaagctg	14	13	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:144508056G>A	uc003qks.3	+	2	484	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	98					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GGCCCGGGGCGAGGTCATCCA	0.682									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.013537	0	13	15										A	144508056	G	A	144508056	3	1	39	1	0	0	0	0	1	0	0	0	15336	1059	37	1	294	1	STX11	6	144508056	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5401675	144508056	26607011	97	9500										
PPP1R14C	81706	broad.mit.edu	37	chr6	150535916	150535916	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggtagaaattgacattgatGatcttcttgatgcagacagt	10	5	2	6			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:150535916G>A	uc003qnt.2	+	2	484	c.343G>A	c.(343-345)GAT>AAT	p.D115N		NM_030949	NP_112211	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	115					regulation of phosphorylation	cytoplasm|membrane					0		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		TGACATTGATGATCTTCTTGA	0.413													0	0	0	0.028581	0	15	53										A	150535916	G	A	150535916	3	1	39	1	0	0	0	0	1	0	0	0	12361	1290	45	1	349	1	PPP1R14C	6	150535916	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	6027860	150535916	20579151	98	9501										
PARK2	5071	broad.mit.edu	37	chr6	162622255	162622255	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acaggggcctttgcaatacaCataaaagctgttgtagattg	10	7	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:162622255C>A	uc003qtx.3	-	4	576	c.442G>T	c.(442-444)GTG>TTG	p.V148L	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_5'UTR|PARK2_uc003qtw.3_Intron|PARK2_uc003qty.3_Missense_Mutation_p.V148L|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Missense_Mutation_p.V148L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	148					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TTGCAATACACATAAAAGCTG	0.458													1	0	0.000442599	0.006214	0.000453596	9	38										A	162622255	C	A	162622255	3	1	39	1	0	0	0	0	1	0	0	0	11449	478	17	4	991	4	PARK2	6	162622255	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	12086339	162622255	8492812	99	9502										
MLLT4	4301	broad.mit.edu	37	chr6	168317781	168317782	+	Frame_Shift_Ins	INS	-	-	T													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tacataggcaacgactttgcINSttaccatggataagtatgca							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:168317781_168317782insT	uc003qwd.2	+	19	2696_2697	c.2554_2555insT	c.(2554-2556)CTTfs	p.L852fs	MLLT4_uc003qwb.1_Frame_Shift_Ins_p.L837fs|MLLT4_uc003qwc.1_Frame_Shift_Ins_p.L853fs|MLLT4_uc003qwg.1_Frame_Shift_Ins_p.L162fs	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	853	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AACGACTTTGCTTACCATGGAT	0.277			T	MLL	AL													15	46	---	---								T	168317782	-	T	168317781	7	5	39	1	0	1	1	0	0	0	0	0	9629	797	28	0	2631	0	MLLT4	6	168317781	Frame_Shift_Ins	INS	-	TCGA-CU-A3YL-01A-11D-A22Z-08	5695526	168317781	2797286	100	9503										
PURB	5814	broad.mit.edu	37	chr7	44924074	44924074	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctgcccccaccacgtcgctCataaagcttatccctctgtc	6	18	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:44924074C>T	uc003tme.2	-	1	887	c.874G>A	c.(874-876)GAG>AAG	p.E292K		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	292					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCACGTCGCTCATAAAGCTTA	0.592													0	0	0	0.024334	0	25	62										T	44924074	C	T	44924074	3	4	39	1	0	0	0	0	1	0	0	0	12828	835	29	1	68	1	PURB	7	44924074	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		44924074	114214589	101	9504										
ZNF680	340252	broad.mit.edu	37	chr7	63982867	63982867	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccaaaggtcttcagtgaaatGagaatatataactgaaagac	8	6	2	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:63982867G>C	uc003tta.2	-	4	438	c.265C>G	c.(265-267)CAT>GAT	p.H89D	ZNF680_uc010kzr.2_Missense_Mutation_p.H16D	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				TCAGTGAAATGAGAATATATA	0.289													0	0	0	0.006214	0	9	14										C	63982867	G	C	63982867	3	2	39	1	0	0	0	0	1	0	0	0	18084	1290	45	1	1331	1	ZNF680	7	63982867	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	19058793	63982867	95155796	102	9505										
TMEM120A	83862	broad.mit.edu	37	chr7	75617241	75617241	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagacatctgggacactcacTctggtacatggaaaaggaga	11	9	3	2	rs35558484		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:75617241T>G	uc003ued.2	-	9	795	c.691A>C	c.(691-693)AGC>CGC	p.S231R	TMEM120A_uc003uee.2_Missense_Mutation_p.E169A|TMEM120A_uc003ueb.1_Missense_Mutation_p.S17R|TMEM120A_uc003uec.2_Missense_Mutation_p.S135R	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	231	Cytoplasmic (Potential).					integral to membrane					0						GGACACTCACTCTGGTACATG	0.612													0	0	0	0.021553	0	5	5										G	75617241	T	G	75617241	3	3	39	1	0	0	0	0	1	0	0	0	16030	1565	54	5	360	5	TMEM120A	7	75617241	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	11634374	75617241	83521422	103	9506										
PTPN12	5782	broad.mit.edu	37	chr7	77200497	77200497	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaacagatacaaggacataCtgccatgtaagttggaaatg	10	6	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:77200497C>T	uc003ugh.2	+	2	293	c.202C>T	c.(202-204)CTG>TTG	p.L68L	PTPN12_uc011kgp.1_5'UTR|PTPN12_uc011kgq.1_5'UTR|PTPN12_uc010ldq.1_RNA|PTPN12_uc010ldr.1_RNA	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	68	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						CAAGGACATACTGCCATGTAA	0.328													0	0	0	0.021553	0	6	18										T	77200497	C	T	77200497	2	4	39	1	0	0	0	0	0	0	0	1	12781	564	20	2		2	PTPN12	7	77200497	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1583256	77200497	81938166	104	9507										
OCM2	4951	broad.mit.edu	37	chr7	97619396	97619396	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctgcaatgtcatcagcactGagcacgtccgtgatgctcat	10	12	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:97619396G>A	uc003upc.2	-	1	21	c.21C>T	c.(19-21)CTC>CTT	p.L7L		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	7							calcium ion binding				0						CATCAGCACTGAGCACGTCCG	0.552													0	0	0	0.006214	0	8	23										A	97619396	G	A	97619396	2	1	39	1	0	0	0	0	0	0	0	1	10822	1277	45	1		1	OCM2	7	97619396	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	20418899	97619396	61519267	105	9508										
CNTNAP2	26047	broad.mit.edu	37	chr7	146805319	146805319	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agatgaaaacactgaaagatGtcattgccttgaactttaag	8	6	1	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:146805319G>T	uc003weu.1	+	5	1147	c.631G>T	c.(631-633)GTC>TTC	p.V211F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	211	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACTGAAAGATGTCATTGCCTT	0.363										HNSCC(39;0.1)			1	0	2.35188e-11	0.006122	2.51987e-11	19	27										T	146805319	G	T	146805319	3	4	39	1	0	0	0	0	1	0	0	0	3647	1377	48	4	649	4	CNTNAP2	7	146805319	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	49185923	146805319	12333344	106	9509										
CUL1	8454	broad.mit.edu	37	chr7	148481129	148481129	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aatcatccagtaaatcccctGagttgctggctcgatactgt	8	11	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148481129G>A	uc010lpg.2	+	11	1784	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	CUL1_uc003wey.2_Missense_Mutation_p.E420K|CUL1_uc003wez.2_Missense_Mutation_p.E310K|CUL1_uc003wfa.2_Missense_Mutation_p.E81K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	420					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TAAATCCCCTGAGTTGCTGGC	0.418													0	0	0	0.006122	0	19	33										A	148481129	G	A	148481129	3	1	39	1	0	0	0	0	1	0	0	0	4054	1291	45	1	1296	1	CUL1	7	148481129	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1675810	148481129	10657534	107	9510										
ZNF425	155054	broad.mit.edu	37	chr7	148801438	148801438	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgcgtgagccgcgactgctGagaaaaggtctttttgcact	12	10	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148801438G>C	uc003wfj.2	-	4	1598	c.1525C>G	c.(1525-1527)CAG>GAG	p.Q509E		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	509	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGCGACTGCTGAGAAAAGGTC	0.637													0	0	0	0.004482	0	8	12										C	148801438	G	C	148801438	3	2	39	1	0	0	0	0	1	0	0	0	17896	1299	45	1	737	1	ZNF425	7	148801438	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	320309	148801438	10337225	108	9511										
ZNF425	155054	broad.mit.edu	37	chr7	148802519	148802519	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tttagaatctctgtttctcgGagacttggagactggaaggt	12	6	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148802519G>C	uc003wfj.2	-	4	517	c.444C>G	c.(442-444)CTC>CTG	p.L148L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	148					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTGTTTCTCGGAGACTTGGAG	0.458													0	0	0	0.016522	0	24	49										C	148802519	G	C	148802519	2	2	39	1	0	0	0	0	0	0	0	1	17896	1161	41	1		1	ZNF425	7	148802519	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1081	148802519	10336144	109	9512										
ZNF777	27153	broad.mit.edu	37	chr7	149152911	149152911	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcacatgtggcatccggccaGaagtctcttgcttgggagca	13	11	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:149152911G>A	uc003wfv.2	-	2	366	c.203C>T	c.(202-204)TCT>TTT	p.S68F		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CATCCGGCCAGAAGTCTCTTG	0.577													0	0	0	0.027356	0	28	64										A	149152911	G	A	149152911	3	1	39	1	0	0	0	0	1	0	0	0	18147	942	33	1	2312	1	ZNF777	7	149152911	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	350392	149152911	9985752	110	9513										
GIMAP7	168537	broad.mit.edu	37	chr7	150217669	150217669	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acgaaggggcttacttttctGatgacatatacaaggacaca	9	8	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:150217669G>C	uc003whk.2	+	2	737	c.607G>C	c.(607-609)GAT>CAT	p.D203H		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	203							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTACTTTTCTGATGACATATA	0.418													0	0	0	0.006122	0	19	35										C	150217669	G	C	150217669	3	2	39	1	0	0	0	0	1	0	0	0	6384	1290	45	1	609	1	GIMAP7	7	150217669	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1064758	150217669	8920994	111	9514										
WDR60	55112	broad.mit.edu	37	chr7	158663923	158663923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggaccttcctgaacataagGagccgaggtgcagggatccc	13	11	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:158663923G>A	uc003woe.3	+	3	318	c.160G>A	c.(160-162)GAG>AAG	p.E54K		NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	54										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TGAACATAAGGAGCCGAGGTG	0.507													0	0	0	0.004482	0	8	12										A	158663923	G	A	158663923	3	1	39	1	0	0	0	0	1	0	0	0	17308	1175	41	1	170	1	WDR60	7	158663923	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	8446254	158663923	474740	112	9515										
MTUS1	57509	broad.mit.edu	37	chr8	17507472	17507472	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tacatgatctgaggatttttCtggaaaggacacagcaagat	10	6	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:17507472C>T	uc003wxv.2	-	13	3859	c.3385_splice	c.e13-1	p.K1129_splice	MTUS1_uc003wxt.2_Splice_Site_p.K376_splice|MTUS1_uc011kyg.1_Splice_Site_p.K274_splice|MTUS1_uc010lsy.2_Splice_Site|MTUS1_uc003wxw.2_Splice_Site_p.K1075_splice|MTUS1_uc003wxs.2_Splice_Site_p.K295_splice	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1							Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GAGGATTTTTCTGGAAAGGAC	0.368													0	0	0	0.010818	0	33	15										T	17507472	C	T	17507472	5	4	39	1	0	0	0	0	0	0	1	0	9965	927	32	1	440	1	MTUS1	8	17507472	Splice_Site	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		17507472	128856550	113	9516										
MYST3	7994	broad.mit.edu	37	chr8	41790517	41790517	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggttgagagtagctgccggCaccaaaatcccctggaatcc	11	12	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:41790517C>A	uc010lxb.2	-	18	5765	c.5221G>T	c.(5221-5223)GCC>TCC	p.A1741S	MYST3_uc010lxc.2_Missense_Mutation_p.A1741S|MYST3_uc003xon.3_Missense_Mutation_p.A1741S	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1741					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TAGCTGCCGGCACCAAAATCC	0.498													1	0	8.88839e-20	0.010818	9.61695e-20	34	75										A	41790517	C	A	41790517	3	1	39	1	0	0	0	0	1	0	0	0	10104	710	25	4	797	4	MYST3	8	41790517	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	24283045	41790517	104573505	114	9517										
STK3	6788	broad.mit.edu	37	chr8	99468130	99468130	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tccagaatgggctgtcttttCgcagtgtatctctgacgaag	11	9	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:99468130C>T	uc003yip.2	-	11	1557	c.1416G>A	c.(1414-1416)GCG>GCA	p.A472A	STK3_uc003yio.2_Silent_p.A500A	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	472	SARAH.|Potential.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		GCTGTCTTTTCGCAGTGTATC	0.408													0	0	0	0.006214	0	9	11										T	99468130	C	T	99468130	2	4	39	1	0	0	0	0	0	0	0	1	15294	871	31	1		1	STK3	8	99468130	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	57677613	99468130	46895892	115	9518										
ATAD2	29028	broad.mit.edu	37	chr8	124371477	124371477	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttaccttgggggttgaatttTaaatttttcaaagacttctg	8	5	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:124371477T>A	uc003yqh.3	-	11	1474	c.1366A>T	c.(1366-1368)AAA>TAA	p.K456*	ATAD2_uc011lii.1_Nonsense_Mutation_p.K247*|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Nonsense_Mutation_p.K456*	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GGTTGAATTTTAAATTTTTCA	0.323													0	0	0	0.024334	0	25	41										A	124371477	T	A	124371477	4	1	39	1	0	0	0	0	0	1	0	0	1071	1763	61	5	2878	5	ATAD2	8	124371477	Nonsense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	24903347	124371477	21992545	116	9519										
PLEC	5339	broad.mit.edu	37	chr8	144993273	144993273	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgccgccgccgggaatgtcGatctgtgtctcttcaaatgc	11	13	3	0	rs34365303		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:144993273G>A	uc003zaf.1	-	32	11297	c.11127C>T	c.(11125-11127)ATC>ATT	p.I3709I	PLEC_uc003zab.1_Silent_p.I3572I|PLEC_uc003zac.1_Silent_p.I3576I|PLEC_uc003zad.2_Silent_p.I3572I|PLEC_uc003zae.1_Silent_p.I3540I|PLEC_uc003zag.1_Silent_p.I3550I|PLEC_uc003zah.2_Silent_p.I3558I|PLEC_uc003zaj.2_Silent_p.I3599I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3709	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGGGAATGTCGATCTGTGTCT	0.632													0	0	0	0.004482	0	7	150										A	144993273	G	A	144993273	2	1	39	1	0	0	0	0	0	0	0	1	12052	1048	37	1		1	PLEC	8	144993273	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	20621796	144993273	1370749	117	9520										
FBXO10	26267	broad.mit.edu	37	chr9	37537289	37537289	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctccttatccttctgcagctCctgctgcagtgagttcagca	8	14	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:37537289C>G	uc004aab.2	-	3	1286	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q	FBXO10_uc004aac.2_Missense_Mutation_p.E429Q|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	413						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		TTCTGCAGCTCCTGCTGCAGT	0.627													0	0	0	0.006214	0	10	1										G	37537289	C	G	37537289	3	3	39	1	0	0	0	0	1	0	0	0	5726	864	30	1	1669	1	FBXO10	9	37537289	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		37537289	103676142	118	9521										
NTRK2	4915	broad.mit.edu	37	chr9	87482169	87482169	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	catctccaggcccagcctccGttatcagcaatgatgatgac	8	14	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:87482169G>A	uc004aoa.1	+	15	2346	c.1408G>A	c.(1408-1410)GTT>ATT	p.V470I	NTRK2_uc004any.1_Missense_Mutation_p.V470I|NTRK2_uc004anz.1_Missense_Mutation_p.V486I|NTRK2_uc011lsz.1_Missense_Mutation_p.V486I|NTRK2_uc011lta.1_Missense_Mutation_p.V470I|NTRK2_uc004aoc.2_Missense_Mutation_p.V21I	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	470	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						CCCAGCCTCCGTTATCAGCAA	0.343										TSP Lung(25;0.17)			0	0	0	0.016522	0	24	43										A	87482169	G	A	87482169	3	1	39	1	0	0	0	0	1	0	0	0	10707	1145	40	2	1548	2	NTRK2	9	87482169	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	49944880	87482169	53731262	119	9522										
ZCCHC6	79670	broad.mit.edu	37	chr9	88938224	88938224	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagtaccttctgtactttctCcatcaagatcagccttgtta	5	12	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:88938224C>G	uc004aoq.2	-	13	2656	c.2441G>C	c.(2440-2442)GGA>GCA	p.G814A	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.G691A|ZCCHC6_uc004aou.2_Missense_Mutation_p.G814A	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	814					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TGTACTTTCTCCATCAAGATC	0.423													0	0	0	0.007291	0	28	62										G	88938224	C	G	88938224	3	3	39	1	0	0	0	0	1	0	0	0	17589	855	30	1	2106	1	ZCCHC6	9	88938224	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1456055	88938224	52275207	120	9523										
FAM75C1	441452	broad.mit.edu	37	chr9	90537046	90537046	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaggcttcaggcctcctcaCctgcatgtaagcagttccag	10	13	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:90537046C>G	uc010mqi.2	+	4	2253	c.2224C>G	c.(2224-2226)CCT>GCT	p.P742A	FAM75C1_uc004apq.3_Missense_Mutation_p.P725A	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGCCTCCTCACCTGCATGTAA	0.577													0	0	0	0.00499	0	16	39										G	90537046	C	G	90537046	3	3	39	1	0	0	0	0	1	0	0	0	5623	507	18	4	2238	4	FAM75C1	9	90537046	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1598822	90537046	50676385	121	9524										
NR4A3	8013	broad.mit.edu	37	chr9	102590462	102590462	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atggaccttggcagcactgaGatcacggctacagccaccac	10	14	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:102590462G>A	uc004baf.1	+	3	867	c.138G>A	c.(136-138)GAG>GAA	p.E46E	NR4A3_uc004bae.2_Silent_p.E46E|NR4A3_uc004bag.1_Silent_p.E46E|NR4A3_uc004bai.2_Silent_p.E57E	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	46					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCAGCACTGAGATCACGGCTA	0.562			T	EWSR1	extraskeletal myxoid chondrosarcoma								0	0	0	0.012319	0	19	39										A	102590462	G	A	102590462	2	1	39	1	0	0	0	0	0	0	0	1	10634	933	33	1		1	NR4A3	9	102590462	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12053416	102590462	38622969	122	9525										
FKBP15	23307	broad.mit.edu	37	chr9	115931520	115931520	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atacctggaacgctgggaatGatggctgggtctgagggctg	17	7	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:115931520G>A	uc004bgs.2	-	26	3587	c.3469C>T	c.(3469-3471)CAT>TAT	p.H1157Y	FKBP15_uc004bgr.2_Missense_Mutation_p.H594Y|FKBP15_uc011lxc.1_Missense_Mutation_p.H738Y|FKBP15_uc011lxd.1_Missense_Mutation_p.H1089Y	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	1157					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						CGCTGGGAATGATGGCTGGGT	0.542													0	0	0	0.013537	0	13	15										A	115931520	G	A	115931520	3	1	39	1	0	0	0	0	1	0	0	0	5905	1290	45	1	202	1	FKBP15	9	115931520	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	13341058	115931520	25281911	123	9526										
TRIM32	22954	broad.mit.edu	37	chr9	119461874	119461874	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tattcgagagggacttacctGtccggtgggcatagccctaa	12	10	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:119461874G>A	uc004bjx.2	+	2	2011	c.1853G>A	c.(1852-1854)TGT>TAT	p.C618Y	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Missense_Mutation_p.C618Y	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	618	NHL 5.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GGACTTACCTGTCCGGTGGGC	0.507									Bardet-Biedl_syndrome				0	0	0	0.006122	0	18	38										A	119461874	G	A	119461874	3	1	39	1	0	0	0	0	1	0	0	0	16503	1377	48	2	1855	2	TRIM32	9	119461874	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	3530354	119461874	21751557	124	9527										
WDR34	89891	broad.mit.edu	37	chr9	131396647	131396647	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acatgcccgtcagtcccagcGctcaggaagagattcctaga	10	13	2	2	rs146817584		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:131396647G>A	uc004bvq.1	-	8	1354	c.1230C>T	c.(1228-1230)AGC>AGT	p.S410S	WDR34_uc004bvs.1_Silent_p.S401S|WDR34_uc004bvr.1_Silent_p.S382S	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	410	WD 3.					cytoplasm				central_nervous_system(2)|skin(1)	3						CAGTCCCAGCGCTCAGGAAGA	0.627													0	0	0	0.020292	0	15	34										A	131396647	G	A	131396647	2	1	39	1	0	0	0	0	0	0	0	1	17285	1078	38	2		2	WDR34	9	131396647	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	11934773	131396647	9816784	125	9528										
NUP188	23511	broad.mit.edu	37	chr9	131768567	131768567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcttctacctgctcatctctCaggcgatgcggtaccttagg	10	13	4	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:131768567C>G	uc004bws.1	+	43	5015	c.4993C>G	c.(4993-4995)CAG>GAG	p.Q1665E		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1665					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GCTCATCTCTCAGGCGATGCG	0.572											OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	35	81										G	131768567	C	G	131768567	3	3	39	1	0	0	0	0	1	0	0	0	10758	827	29	1	5163	1	NUP188	9	131768567	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	371920	131768567	9444864	126	9529										
GPR107	57720	broad.mit.edu	37	chr9	132869776	132869779	+	Frame_Shift_Del	DEL	TCAA	TCAA	-													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tctaaatgtttatttttaggTcaatcagacatttacaagaa							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:132869776_132869779delTCAA	uc004bze.2	+	14	1491_1494	c.1264_1267delTCAA	c.(1264-1269)TCAATCfs	p.S422fs	GPR107_uc004bzb.2_Frame_Shift_Del_p.S233fs|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Frame_Shift_Del_p.S422fs|GPR107_uc004bzd.2_Frame_Shift_Del_p.S422fs|uc004bzf.2_5'Flank	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	422_423	Helical; Name=5; (Potential).					integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				TATTTTTAGGTCAATCAGACATTT	0.407											OREG0019542	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						15	11	---	---								-	132869779	TCAA	-	132869776	7	5	39	1	0	1	0	1	0	0	0	0	6623	1681	58	0	1318	0	GPR107	9	132869776	Frame_Shift_Del	DEL	TCAA	TCGA-CU-A3YL-01A-11D-A22Z-08	1101209	132869776	8343655	127	9530										
LCN15	389812	broad.mit.edu	37	chr9	139658915	139658915	+	Frame_Shift_Del	DEL	A	A	-													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcgcccagagcagggtcaggAttgcgccgagcaggaatgac							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:139658915delA	uc004cjd.2	-	1	51	c.26delT	c.(25-27)ATCfs	p.I9fs		NM_203347	NP_976222	Q6UWW0	LCN15_HUMAN	lipocalin 15 precursor	9					lipid metabolic process	extracellular region	binding|transporter activity				0						CAGGGTCAGGATTGCGCCGAG	0.642																		7	7	---	---								-	139658915	A	-	139658915	7	5	39	1	0	1	0	1	0	0	0	0	8683	333	12	0	552	0	LCN15	9	139658915	Frame_Shift_Del	DEL	A	TCGA-CU-A3YL-01A-11D-A22Z-08	6789139	139658915	1554516	128	9531										
GRIN1	2902	broad.mit.edu	37	chr9	140057342	140057342	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atctacgccacggtgaagcaGagctccgtggatatctactt	10	11	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:140057342G>C	uc004clk.2	+	15	2388	c.2058G>C	c.(2056-2058)CAG>CAC	p.Q686H	GRIN1_uc004cli.1_Missense_Mutation_p.Q361H|GRIN1_uc004clj.1_Missense_Mutation_p.Q683H|GRIN1_uc004cll.2_Missense_Mutation_p.Q686H|GRIN1_uc004clm.2_Missense_Mutation_p.Q686H|GRIN1_uc004cln.2_Missense_Mutation_p.Q704H|GRIN1_uc004clo.2_Missense_Mutation_p.Q704H	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	686	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGTGAAGCAGAGCTCCGTGG	0.637													0	0	0	0.004672	0	3	5										C	140057342	G	C	140057342	3	2	39	1	0	0	0	0	1	0	0	0	6778	933	33	1	2183	1	GRIN1	9	140057342	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	398427	140057342	1156089	129	9532										
EHMT1	79813	broad.mit.edu	37	chr9	140695358	140695358	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggaggctggacacccatgatCtgggccacagagtacaagca	13	11	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:140695358C>T	uc011mfc.1	+	18	2671	c.2634C>T	c.(2632-2634)ATC>ATT	p.I878I		NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	878	ANK 5.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CACCCATGATCTGGGCCACAG	0.587													0	0	0	0.009096	0	4	21										T	140695358	C	T	140695358	2	4	39	1	0	0	0	0	0	0	0	1	4983	903	32	1		1	EHMT1	9	140695358	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	638016	140695358	518073	130	9533										
CELF2	10659	broad.mit.edu	37	chr10	11367804	11367804	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttttttcctccttaggtccaGagggggcaaacctctttatt	8	10	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:11367804G>C	uc001iki.3	+	12	1353	c.1261G>C	c.(1261-1263)GAG>CAG	p.E421Q	CELF2_uc010qbj.1_Missense_Mutation_p.E427Q|CELF2_uc001ikk.2_Missense_Mutation_p.E446Q|CELF2_uc001ikl.3_Missense_Mutation_p.E434Q|CELF2_uc010qbl.1_Missense_Mutation_p.E397Q|CELF2_uc010qbm.1_Missense_Mutation_p.E193Q|CELF2_uc001iko.3_Missense_Mutation_p.E401Q|CELF2_uc001ikp.3_Missense_Mutation_p.E403Q|CELF2_uc010qbn.1_Missense_Mutation_p.E409Q|CELF2_uc010qbo.1_Missense_Mutation_p.E316Q|CELF2_uc010qbp.1_Missense_Mutation_p.E193Q	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	421	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						CTTAGGTCCAGAGGGGGCAAA	0.418													0	0	0	0.008291	0	11	36										C	11367804	G	C	11367804	3	2	39	1	0	0	0	0	1	0	0	0	3216	943	33	1	1415	1	CELF2	10	11367804	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		11367804	124166943	131	9534										
TRDMT1	1787	broad.mit.edu	37	chr10	17216603	17216603	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaaattatacttgtatacttCattagcgacagtgttgacat	6	6	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:17216603C>T	uc001iop.2	-	2	169	c.121G>A	c.(121-123)GAA>AAA	p.E41K	TRDMT1_uc001ioq.2_Missense_Mutation_p.E41K|TRDMT1_uc001ior.2_Missense_Mutation_p.E41K|TRDMT1_uc001ios.2_5'UTR|TRDMT1_uc009xjt.2_Missense_Mutation_p.M7I|TRDMT1_uc010qcd.1_Missense_Mutation_p.E41K|TRDMT1_uc009xjs.1_Missense_Mutation_p.M7I|TRDMT1_uc009xju.1_RNA	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	41					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						TTGTATACTTCATTAGCGACA	0.363													0	0	0	0.024245	0	16	47										T	17216603	C	T	17216603	3	4	39	1	0	0	0	0	1	0	0	0	16464	835	29	1	1094	1	TRDMT1	10	17216603	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	5848799	17216603	118318144	132	9535										
ANKRD26	22852	broad.mit.edu	37	chr10	27332447	27332447	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cctctgaggctgtttcagatGactgagttaagtcatcaaca	9	9	4	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:27332447G>A	uc001ith.2	-	20	2238	c.2066C>T	c.(2065-2067)TCA>TTA	p.S689L	ANKRD26_uc001itg.2_Missense_Mutation_p.S376L|ANKRD26_uc009xku.1_Missense_Mutation_p.S690L	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	689						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGTTTCAGATGACTGAGTTAA	0.373													0	0	0	0.008291	0	11	12										A	27332447	G	A	27332447	3	1	39	1	0	0	0	0	1	0	0	0	654	1294	45	1	3123	1	ANKRD26	10	27332447	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	10115844	27332447	108202300	133	9536										
SVIL	6840	broad.mit.edu	37	chr10	29776225	29776225	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcctggtctgcacatgtcttCttcctgaacacgaggcagac	10	13	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:29776225C>G	uc001iut.1	-	24	5105	c.4352G>C	c.(4351-4353)AGA>ACA	p.R1451T	LOC387647_uc001iuq.1_RNA|SVIL_uc010qdw.1_Missense_Mutation_p.R365T|SVIL_uc001iuu.1_Missense_Mutation_p.R1025T|SVIL_uc009xlc.2_Missense_Mutation_p.R243T	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1451	Gelsolin-like 1.|Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CACATGTCTTCTTCCTGAACA	0.582													0	0	0	0.006214	0	9	23										G	29776225	C	G	29776225	3	3	39	1	0	0	0	0	1	0	0	0	15418	913	32	1	2352	1	SVIL	10	29776225	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	2443778	29776225	105758522	134	9537										
MAP3K8	1326	broad.mit.edu	37	chr10	30727904	30727904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctggaagtgacaataaagaaGagattgatttattaattaaa	8	2	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:30727904G>C	uc001ivi.1	+	3	733	c.37G>C	c.(37-39)GAG>CAG	p.E13Q	MAP3K8_uc009xlf.1_Missense_Mutation_p.E13Q|MAP3K8_uc001ivj.1_Missense_Mutation_p.E13Q	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	13					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				CAATAAAGAAGAGATTGATTT	0.323													0	0	0	0.001984	0	7	15										C	30727904	G	C	30727904	3	2	39	1	0	0	0	0	1	0	0	0	9256	943	33	1	39	1	MAP3K8	10	30727904	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	951679	30727904	104806843	135	9538										
MAP3K8	1326	broad.mit.edu	37	chr10	30727994	30727994	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtgaagagccagcagtttatGaacccagtctaatgaccatg	10	9	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:30727994G>C	uc001ivi.1	+	3	823	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	MAP3K8_uc009xlf.1_Missense_Mutation_p.E43Q|MAP3K8_uc001ivj.1_Missense_Mutation_p.E43Q	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	43					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				AGCAGTTTATGAACCCAGTCT	0.363													0	0	0	0.016723	0	14	40										C	30727994	G	C	30727994	3	2	39	1	0	0	0	0	1	0	0	0	9256	1291	45	1	129	1	MAP3K8	10	30727994	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	90	30727994	104806753	136	9539										
BMS1	9790	broad.mit.edu	37	chr10	43292616	43292616	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttgatgagaccagtgatataGaaaatttactcaaagaggaa	9	4	1	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:43292616G>C	uc001jaj.2	+	10	2282	c.1924G>C	c.(1924-1926)GAA>CAA	p.E642Q		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	642					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						CAGTGATATAGAAAATTTACT	0.373													0	0	0	0.008871	0	13	38										C	43292616	G	C	43292616	3	2	39	1	0	0	0	0	1	0	0	0	1472	943	33	1	1958	1	BMS1	10	43292616	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12564622	43292616	92242131	137	9540										
BMS1	9790	broad.mit.edu	37	chr10	43292652	43292652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggaagaagattacaaggaaGaaaataatgattccaaagaa	9	3	0	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:43292652G>C	uc001jaj.2	+	10	2318	c.1960G>C	c.(1960-1962)GAA>CAA	p.E654Q		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	654					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTACAAGGAAGAAAATAATGA	0.383													0	0	0	0.013537	0	5	37										C	43292652	G	C	43292652	3	2	39	1	0	0	0	0	1	0	0	0	1472	943	33	1	1994	1	BMS1	10	43292652	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	36	43292652	92242095	138	9541										
GDF2	2658	broad.mit.edu	37	chr10	48413880	48413880	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gaagtttacccgcagggaggTcttttgacagtggctgccag	14	9	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:48413880T>A	uc001jfa.1	-	2	1151	c.988A>T	c.(988-990)ACC>TCC	p.T330S		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	330					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity	p.T330I(1)		ovary(2)|skin(1)	3						CGCAGGGAGGTCTTTTGACAG	0.607													0	0	0	0.016522	0	24	36										A	48413880	T	A	48413880	3	1	39	1	0	0	0	0	1	0	0	0	6314	1667	58	5	305	5	GDF2	10	48413880	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	5121228	48413880	87120867	139	9542										
ANK3	288	broad.mit.edu	37	chr10	61830481	61830481	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtgatggactggtcgttgttCccattctgggcaatttcatt	11	8	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:61830481C>T	uc001jky.2	-	37	10350	c.10158G>A	c.(10156-10158)GGG>GGA	p.G3386G	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3386					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTCGTTGTTCCCATTCTGGG	0.468													0	0	0	0.015359	0	36	67										T	61830481	C	T	61830481	2	4	39	1	0	0	0	0	0	0	0	1	622	842	30	1		1	ANK3	10	61830481	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	13416601	61830481	73704266	140	9543										
ANK3	288	broad.mit.edu	37	chr10	61831191	61831191	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tacttgctctagagtatcatCttctggactaccttggggag	10	9	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:61831191C>G	uc001jky.2	-	37	9640	c.9448G>C	c.(9448-9450)GAT>CAT	p.D3150H	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3150					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AGAGTATCATCTTCTGGACTA	0.428													0	0	0	0.00632	0	30	72										G	61831191	C	G	61831191	3	3	39	1	0	0	0	0	1	0	0	0	622	913	32	1	4026	1	ANK3	10	61831191	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	710	61831191	73703556	141	9544										
ZMIZ1	57178	broad.mit.edu	37	chr10	81037044	81037044	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctccccatgcagccccctctCagctccatgagctccatgaa	6	19	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:81037044C>G	uc001kaf.2	+	8	959	c.387C>G	c.(385-387)CTC>CTG	p.L129L	ZMIZ1_uc001kag.2_Silent_p.L5L|ZMIZ1_uc001kah.1_Silent_p.L5L	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	129					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCCCCCTCTCAGCTCCATGA	0.622													0	0	0	0.004672	0	3	28										G	81037044	C	G	81037044	2	3	39	1	0	0	0	0	0	0	0	1	17693	813	29	1		1	ZMIZ1	10	81037044	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	19205853	81037044	54497703	142	9545										
ARL3	403	broad.mit.edu	37	chr10	104459170	104459170	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aataattcttccagtatggtCtgattttcctctgtccacca	5	11	3	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:104459170C>G	uc001kwa.2	-	3	382	c.224G>C	c.(223-225)AGA>ACA	p.R75T		NM_004311	NP_004302	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	75					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding				0		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		CCAGTATGGTCTGATTTTCCT	0.358													0	0	0	0.021553	0	6	8										G	104459170	C	G	104459170	3	3	39	1	0	0	0	0	1	0	0	0	935	913	32	1	340	1	ARL3	10	104459170	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	23422126	104459170	31075577	143	9546										
TACC2	10579	broad.mit.edu	37	chr10	123903125	123903125	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccatgcgggtcttcctccctCggctgcagaacacatagttt	9	14	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:123903125C>T	uc001lfv.2	+	7	6098	c.5738C>T	c.(5737-5739)TCG>TTG	p.S1913L	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Intron|TACC2_uc010qtv.1_Intron|TACC2_uc001lfx.2_Intron|TACC2_uc001lfy.2_Intron	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1913						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTTCCTCCCTCGGCTGCAGAA	0.562											OREG0020589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	40										T	123903125	C	T	123903125	3	4	39	1	0	0	0	0	1	0	0	0	15499	893	31	1	5760	1	TACC2	10	123903125	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	19443955	123903125	11631622	144	9547										
MUC6	4588	broad.mit.edu	37	chr11	1026380	1026380	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccagggtaggagacccccgaGaactcacatgggcactcctc	11	15	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:1026380G>A	uc001lsw.2	-	20	2544	c.2493C>T	c.(2491-2493)TTC>TTT	p.F831F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	831					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGACCCCCGAGAACTCACATG	0.647													0	0	0	0.021553	0	6	11										A	1026380	G	A	1026380	2	1	39	1	0	0	0	0	0	0	0	1	9980	933	33	1		1	MUC6	11	1026380	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		1026380	133980136	145	9548										
DCHS1	8642	broad.mit.edu	37	chr11	6643190	6643190	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gacagggagccttcatggctGatgggggagcggtgagaagc	19	7	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:6643190G>A	uc001mem.1	-	21	10127	c.9717C>T	c.(9715-9717)ATC>ATT	p.I3239I	TPP1_uc001mek.1_5'Flank|TPP1_uc001mel.1_5'Flank|TPP1_uc010rar.1_5'Flank	NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	3239	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCATGGCTGATGGGGGAGC	0.642													0	0	0	0.00308	0	7	6										A	6643190	G	A	6643190	2	1	39	1	0	0	0	0	0	0	0	1	4287	1280	45	1		1	DCHS1	11	6643190	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5616810	6643190	128363326	146	9549										
CSRP3	8048	broad.mit.edu	37	chr11	19209781	19209781	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gggccatatctgcgcccataGcacaccttgcagtagatctc	9	14	2	1	rs34075817		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:19209781G>A	uc001mpk.2	-	3	300	c.183C>T	c.(181-183)TGC>TGT	p.C61C		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	61	LIM zinc-binding 1.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						TGCGCCCATAGCACACCTTGC	0.587													0	0	0	0.01892	0	25	48										A	19209781	G	A	19209781	2	1	39	1	0	0	0	0	0	0	0	1	3969	963	34	2		2	CSRP3	11	19209781	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12566591	19209781	115796735	147	9550										
DCDC1	341019	broad.mit.edu	37	chr11	31327862	31327862	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tactttaatcactcttggttGaagtttgtgtctttgagaca	8	6	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:31327862G>C	uc001msv.2	-	5	710	c.508C>G	c.(508-510)CAA>GAA	p.Q170E	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	170	Doublecortin.				intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					ACTCTTGGTTGAAGTTTGTGT	0.368													0	0	0	0.007413	0	20	25										C	31327862	G	C	31327862	3	2	39	1	0	0	0	0	1	0	0	0	4284	1299	45	1	576	1	DCDC1	11	31327862	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12118081	31327862	103678654	148	9551										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57076206	57076206	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cccctgagaacctccagagtCtgggtcacaggtcacctcca	9	16	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:57076206C>G	uc001njr.2	-	5	4291	c.3979G>C	c.(3979-3981)GAC>CAC	p.D1327H	TNKS1BP1_uc001njs.2_Missense_Mutation_p.D1327H|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.D778H	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1327	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CCTCCAGAGTCTGGGTCACAG	0.607													0	0	0	0.01441	0	56	100										G	57076206	C	G	57076206	3	3	39	1	0	0	0	0	1	0	0	0	16317	913	32	1	1234	1	TNKS1BP1	11	57076206	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	25748344	57076206	77930310	149	9552										
PRPF19	27339	broad.mit.edu	37	chr11	60671234	60671234	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gaggctggttgttgatggggTcggtaccattctccgcaatg	15	8	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:60671234T>C	uc001nqf.2	-	2	326	c.119A>G	c.(118-120)GAC>GGC	p.D40G		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	40	U-box.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						GTTGATGGGGTCGGTACCATT	0.532													0	0	0	0.014323	0	22	42										C	60671234	T	C	60671234	3	2	39	1	0	0	0	0	1	0	0	0	12564	1667	58	5	1455	5	PRPF19	11	60671234	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	3595028	60671234	74335282	150	9553										
TMEM216	51259	broad.mit.edu	37	chr11	61161357	61161357	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctggcttttgtattggcaggTgtcctgctaccatatccaac	9	11	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:61161357T>G	uc010rlj.1	+	3	410	c.117T>G	c.(115-117)GGT>GGG	p.G39G	TMEM216_uc001nrn.1_5'UTR	NM_016499	NP_057583	Q9P0N5	TM216_HUMAN	transmembrane protein 216	39						integral to membrane					0						TATTGGCAGGTGTCCTGCTAC	0.438													0	0	0	0.006214	0	6	20										G	61161357	T	G	61161357	2	3	39	1	0	0	0	0	0	0	0	1	16136	1710	59	5		5	TMEM216	11	61161357	Silent	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	490123	61161357	73845159	151	9554										
MARK2	2011	broad.mit.edu	37	chr11	63666131	63666131	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aacgctctaccttgtcatggAgtacgctagtggcggtaggt	13	9	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:63666131A>T	uc001nxw.2	+	5	968	c.389A>T	c.(388-390)GAG>GTG	p.E130V	MARK2_uc001nxx.2_Missense_Mutation_p.E130V|MARK2_uc001nxy.2_Missense_Mutation_p.E130V|MARK2_uc001nxv.3_Missense_Mutation_p.E130V|MARK2_uc001nxz.3_Missense_Mutation_p.E97V|MARK2_uc009yoy.2_Missense_Mutation_p.E97V	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CTTGTCATGGAGTACGCTAGT	0.498													0	0	0	0.027356	0	26	45										T	63666131	A	T	63666131	3	4	39	1	0	0	0	0	1	0	0	0	9313	304	11	5	407	5	MARK2	11	63666131	Missense_Mutation	SNP	A	TCGA-CU-A3YL-01A-11D-A22Z-08	2504774	63666131	71340385	152	9555										
FERMT3	83706	broad.mit.edu	37	chr11	63978782	63978782	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgttccgggggatgccagctCacttctcggacagcgcccag	13	14	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:63978782C>T	uc001nyl.2	+	5	699	c.550C>T	c.(550-552)CAC>TAC	p.H184Y	FERMT3_uc001nym.2_Missense_Mutation_p.H184Y	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	184					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GATGCCAGCTCACTTCTCGGA	0.706													0	0	0	0.013537	0	11	9										T	63978782	C	T	63978782	3	4	39	1	0	0	0	0	1	0	0	0	5819	826	29	1	564	1	FERMT3	11	63978782	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	312651	63978782	71027734	153	9556										
MEN1	4221	broad.mit.edu	37	chr11	64575138	64575138	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagcgcatgtatgatcctttCaggtacagccagctcttagg	10	11	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:64575138C>T	uc001obj.2	-	4	757	c.684G>A	c.(682-684)CTG>CTA	p.L228L	MEN1_uc001obk.2_Silent_p.L228L|MEN1_uc001obl.2_Silent_p.L188L|MEN1_uc001obm.2_Silent_p.L223L|MEN1_uc001obn.2_Silent_p.L228L|MEN1_uc001obo.2_Silent_p.L228L|MEN1_uc001obp.2_Silent_p.L223L|MEN1_uc001obq.2_Silent_p.L228L|MEN1_uc001obr.2_Silent_p.L228L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	228	Interaction with FANCD2.		L -> P (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						ATGATCCTTTCAGGTACAGCC	0.552			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01892	0	23	22										T	64575138	C	T	64575138	2	4	39	1	0	0	0	0	0	0	0	1	9472	813	29	1		1	MEN1	11	64575138	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	596356	64575138	70431378	154	9557										
DPP3	10072	broad.mit.edu	37	chr11	66259013	66259013	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agatgctggcccagtatataGagagcttcacccagggctcc	11	12	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:66259013G>A	uc001oig.1	+	8	909	c.847G>A	c.(847-849)GAG>AAG	p.E283K	DPP3_uc001oif.1_Missense_Mutation_p.E283K|DPP3_uc010rpe.1_Missense_Mutation_p.E272K	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	283					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						CCAGTATATAGAGAGCTTCAC	0.657											OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00499	0	16	25										A	66259013	G	A	66259013	3	1	39	1	0	0	0	0	1	0	0	0	4728	943	33	1	873	1	DPP3	11	66259013	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1683875	66259013	68747503	155	9558										
ADRBK1	156	broad.mit.edu	37	chr11	67052379	67052379	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tccaagatgggcaaccccttCctgacccagtggcagcggcg	12	15	0	2	rs1051181		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:67052379C>G	uc009yrn.1	+	19	1982	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	572	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCAACCCCTTCCTGACCCAGT	0.667													0	0	0	0.010729	0	12	22										G	67052379	C	G	67052379	3	3	39	1	0	0	0	0	1	0	0	0	343	854	30	1	1790	1	ADRBK1	11	67052379	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	793366	67052379	67954137	156	9559										
SYTL2	54843	broad.mit.edu	37	chr11	85445049	85445049	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gatttatctttgggttcattGatggttggtgaattctccat	10	5	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:85445049G>C	uc010rth.1	-	6	1596	c.1320C>G	c.(1318-1320)ATC>ATG	p.I440M	SYTL2_uc010rtg.1_Missense_Mutation_p.I441M|SYTL2_uc010rti.1_Missense_Mutation_p.I440M|SYTL2_uc010rtj.1_Missense_Mutation_p.I392M|SYTL2_uc001pbf.3_Missense_Mutation_p.I440M|SYTL2_uc010rtf.1_Missense_Mutation_p.I298M	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	440					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGGTTCATTGATGGTTGGTG	0.383													0	0	0	0.00632	0	30	64										C	85445049	G	C	85445049	3	2	39	1	0	0	0	0	1	0	0	0	15480	1280	45	1	4017	1	SYTL2	11	85445049	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	18392670	85445049	49561467	157	9560										
SYTL2	54843	broad.mit.edu	37	chr11	85445395	85445395	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	catgctttaatggctccaggGagtttggggaagagttgtct	14	6	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:85445395G>C	uc010rth.1	-	6	1250	c.974C>G	c.(973-975)TCC>TGC	p.S325C	SYTL2_uc010rtg.1_Missense_Mutation_p.S326C|SYTL2_uc010rti.1_Missense_Mutation_p.S325C|SYTL2_uc010rtj.1_Missense_Mutation_p.S277C|SYTL2_uc001pbf.3_Missense_Mutation_p.S325C|SYTL2_uc010rtf.1_Missense_Mutation_p.S183C	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	325					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGCTCCAGGGAGTTTGGGGA	0.448													0	0	0	0.009535	0	32	74										C	85445395	G	C	85445395	3	2	39	1	0	0	0	0	1	0	0	0	15480	1174	41	1	4363	1	SYTL2	11	85445395	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	346	85445395	49561121	158	9561										
OR8D2	283160	broad.mit.edu	37	chr11	124189263	124189263	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atggggattattgtgatgtaGaacacagaagacaccttctc	10	7	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:124189263G>A	uc010sah.1	-	1	831	c.831C>T	c.(829-831)TTC>TTT	p.F277F		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TTGTGATGTAGAACACAGAAG	0.423													0	0	0	0.013726	0	33	54										A	124189263	G	A	124189263	2	1	39	1	0	0	0	0	0	0	0	1	11232	933	33	1		1	OR8D2	11	124189263	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	38743868	124189263	10817253	159	9562										
KCNJ1	3758	broad.mit.edu	37	chr11	128709677	128709677	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctaagatggccccacacatGaaagaattgattataactcc	7	10	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:128709677G>C	uc001qeo.1	-	2	570	c.519C>G	c.(517-519)TTC>TTG	p.F173L	KCNJ1_uc001qep.1_Missense_Mutation_p.F154L|KCNJ1_uc001qeq.1_Missense_Mutation_p.F154L|KCNJ1_uc001qer.1_Missense_Mutation_p.F154L|KCNJ1_uc001qes.1_Missense_Mutation_p.F154L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	173	Helical; Name=M2; (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CCCCACACATGAAAGAATTGA	0.458													0	0	0	0.019004	0	36	51										C	128709677	G	C	128709677	3	2	39	1	0	0	0	0	1	0	0	0	8043	1281	45	1	660	1	KCNJ1	11	128709677	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4520414	128709677	6296839	160	9563										
CHD4	1108	broad.mit.edu	37	chr12	6700750	6700750	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggtctagcatcttggtcatCtgcaaaagaagcacggttta	10	8	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:6700750C>T	uc001qpo.2	-	22	3387	c.3223_splice	c.e22-1	p.M1075_splice	CHD4_uc001qpn.2_Splice_Site_p.M1068_splice|CHD4_uc001qpp.2_Splice_Site_p.M1072_splice	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCTTGGTCATCTGCAAAAGAA	0.453													0	0	0	0.01441	0	67	89										T	6700750	C	T	6700750	5	4	39	1	0	0	0	0	0	0	1	0	3327	927	32	1	2592	1	CHD4	12	6700750	Splice_Site	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		6700750	127151145	161	9564										
DENND5B	160518	broad.mit.edu	37	chr12	31605240	31605240	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aagtctttcagaaccatattCttcagtttgctggtactctc	6	10	5	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:31605240C>G	uc001rki.1	-	5	1449	c.1263G>C	c.(1261-1263)AAG>AAC	p.K421N	DENND5B_uc001rkh.1_Missense_Mutation_p.K456N|DENND5B_uc009zjq.1_Missense_Mutation_p.K340N|DENND5B_uc001rkj.2_Missense_Mutation_p.K443N|DENND5B_uc001rkk.1_Missense_Mutation_p.K343N	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	421						integral to membrane				ovary(1)|central_nervous_system(1)	2						GAACCATATTCTTCAGTTTGC	0.408													0	0	0	0.012213	0	31	52										G	31605240	C	G	31605240	3	3	39	1	0	0	0	0	1	0	0	0	4437	912	32	1	2629	1	DENND5B	12	31605240	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	24904490	31605240	102246655	162	9565										
LRRK2	120892	broad.mit.edu	37	chr12	40699617	40699617	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agattggctgtcttgaaaatCtgacatctctggatgtcagt	10	7	4	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:40699617C>T	uc001rmg.3	+	28	3929	c.3808C>T	c.(3808-3810)CTG>TTG	p.L1270L	LRRK2_uc009zjw.2_Silent_p.L108L|LRRK2_uc001rmi.2_Silent_p.L103L	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1270	LRR 12.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCTTGAAAATCTGACATCTCT	0.403													0	0	0	0.008871	0	20	32										T	40699617	C	T	40699617	2	4	39	1	0	0	0	0	0	0	0	1	9033	912	32	1		1	LRRK2	12	40699617	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	9094377	40699617	93152278	163	9566										
MLL2	8085	broad.mit.edu	37	chr12	49434621	49434621	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cacccaggtgggtgcctgagGagggtgagtcaacaaagccc	15	11	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:49434621G>A	uc001rta.3	-	31	6932	c.6932C>T	c.(6931-6933)TCC>TTC	p.S2311F		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2311	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGTGCCTGAGGAGGGTGAGTC	0.612			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.024245	0	16	23										A	49434621	G	A	49434621	3	1	39	1	0	0	0	0	1	0	0	0	9621	1174	41	1	9777	1	MLL2	12	49434621	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	8735004	49434621	84417274	164	9567										
SMARCC2	6601	broad.mit.edu	37	chr12	56563943	56563943	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tataccttgggctccttcttCtcatctgtggcctggccttc	8	14	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:56563943C>G	uc001skb.2	-	22	2410	c.2304G>C	c.(2302-2304)GAG>GAC	p.E768D	SMARCC2_uc001skd.2_Missense_Mutation_p.E799D|SMARCC2_uc001ska.2_Missense_Mutation_p.E799D|SMARCC2_uc001skc.2_Missense_Mutation_p.E798D|SMARCC2_uc010sqf.1_Missense_Mutation_p.E688D	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	768	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GCTCCTTCTTCTCATCTGTGG	0.537													0	0	0	0.013537	0	11	26										G	56563943	C	G	56563943	3	3	39	1	0	0	0	0	1	0	0	0	14776	912	32	1	1368	1	SMARCC2	12	56563943	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	7129322	56563943	77287952	165	9568										
SLC39A5	283375	broad.mit.edu	37	chr12	56629471	56629471	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctggggcttttgcggcaccGagggctcaggccagtgagtg	18	10	1	1	rs145666015		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:56629471G>C	uc010sqj.1	+	8	1189	c.932G>C	c.(931-933)CGA>CCA	p.R311P	SLC39A5_uc010sqi.1_Missense_Mutation_p.R202P|SLC39A5_uc010sqk.1_Missense_Mutation_p.R311P	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	311	Cytoplasmic (Potential).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTGCGGCACCGAGGGCTCAGG	0.532													0	0	0	0.023175	0	41	86										C	56629471	G	C	56629471	3	2	39	1	0	0	0	0	1	0	0	0	14621	1058	37	1	950	1	SLC39A5	12	56629471	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	65528	56629471	77222424	166	9569										
TMEM194A	23306	broad.mit.edu	37	chr12	57472433	57472433	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	accaagcagccggagaggatCaagagtagccgcactgtccc	12	13	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:57472433C>G	uc001smy.2	-	1	142	c.96G>C	c.(94-96)TTG>TTC	p.L32F	TMEM194A_uc001smx.2_Missense_Mutation_p.L32F|TMEM194A_uc010sra.1_5'UTR	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	32	Helical; (Potential).					integral to membrane					0						CGGAGAGGATCAAGAGTAGCC	0.657													0	0	0	0.00499	0	15	35										G	57472433	C	G	57472433	3	3	39	1	0	0	0	0	1	0	0	0	16113	825	29	1	1274	1	TMEM194A	12	57472433	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	842962	57472433	76379462	167	9570										
LRP1	4035	broad.mit.edu	37	chr12	57550665	57550665	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcggacctgccgctgccgttCcggcttcagcctgggcagtg	15	15	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:57550665C>G	uc001snd.2	+	10	1989	c.1523C>G	c.(1522-1524)TCC>TGC	p.S508C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	508	EGF-like 3.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGCTGCCGTTCCGGCTTCAGC	0.632													0	0	0	0.021553	0	5	13										G	57550665	C	G	57550665	3	3	39	1	0	0	0	0	1	0	0	0	8951	855	30	1	1561	1	LRP1	12	57550665	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	78232	57550665	76301230	168	9571										
TBK1	29110	broad.mit.edu	37	chr12	64882283	64882283	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttagtgaattaattaaagatGattacaatgaaactgttcac	6	4	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:64882283G>A	uc001ssc.1	+	12	1419	c.1357G>A	c.(1357-1359)GAT>AAT	p.D453N		NM_013254	NP_037386	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	453					I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)		AATTAAAGATGATTACAATGA	0.269													0	0	0	0.00308	0	7	8										A	64882283	G	A	64882283	3	1	39	1	0	0	0	0	1	0	0	0	15634	1290	45	1	1399	1	TBK1	12	64882283	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	7331618	64882283	68969612	169	9572										
RPL6	6128	broad.mit.edu	37	chr12	112843711	112843711	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgtctgggcttccgcagcttCttcttcttgaagtaagcatc	9	11	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:112843711C>T	uc001ttu.2	-	6	889	c.660G>A	c.(658-660)AAG>AAA	p.K220K	RPL6_uc001ttv.2_Silent_p.K220K	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6	220					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1						TCCGCAGCTTCTTCTTCTTGA	0.423													0	0	0	0.028581	0	16	31										T	112843711	C	T	112843711	2	4	39	1	0	0	0	0	0	0	0	1	13598	912	32	1		1	RPL6	12	112843711	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	47961428	112843711	21008184	170	9573										
TMEM120B	144404	broad.mit.edu	37	chr12	122199641	122199641	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cattctcatcagcaacggctCaaggtacctgggcacctggc	10	14	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:122199641C>G	uc001ubc.3	+	6	692	c.548C>G	c.(547-549)TCA>TGA	p.S183*	TMEM120B_uc009zxh.2_Nonsense_Mutation_p.S183*	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	183						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		AGCAACGGCTCAAGGTACCTG	0.557													0	0	0	0.020292	0	14	31										G	122199641	C	G	122199641	4	3	39	1	0	0	0	0	0	1	0	0	16031	838	29	1	570	1	TMEM120B	12	122199641	Nonsense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	9355930	122199641	11652254	171	9574										
ZCCHC8	55596	broad.mit.edu	37	chr12	122962400	122962400	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaacctacctgaatcgagctCcatgtcggcgggagatcccg	11	13	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:122962400C>G	uc001ucn.2	-	13	1464	c.1333G>C	c.(1333-1335)GAG>CAG	p.E445Q	ZCCHC8_uc001ucl.2_Missense_Mutation_p.E56Q|ZCCHC8_uc001ucm.2_Missense_Mutation_p.E207Q|ZCCHC8_uc009zxp.2_Missense_Mutation_p.E207Q|ZCCHC8_uc009zxq.2_Missense_Mutation_p.E207Q	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	445						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GAATCGAGCTCCATGTCGGCG	0.343													0	0	0	0.006214	0	10	14										G	122962400	C	G	122962400	3	3	39	1	0	0	0	0	1	0	0	0	17591	864	30	1	798	1	ZCCHC8	12	122962400	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	762759	122962400	10889495	172	9575										
NCOR2	9612	broad.mit.edu	37	chr12	124821437	124821437	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gaggttcttcgcaggggtgcGggcgatggtggcgtggccag	21	8	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:124821437G>A	uc010tay.1	-	40	6163	c.6007C>T	c.(6007-6009)CGC>TGC	p.R2003C	NCOR2_uc010taz.1_Missense_Mutation_p.R1987C|NCOR2_uc010tax.1_Missense_Mutation_p.R114C	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2004					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCAGGGGTGCGGGCGATGGTG	0.731													0	0	0	0.00308	0	8	13										A	124821437	G	A	124821437	3	1	39	1	0	0	0	0	1	0	0	0	10236	1116	39	2	1607	2	NCOR2	12	124821437	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1859037	124821437	9030458	173	9576										
ZMYM5	9205	broad.mit.edu	37	chr13	20411884	20411884	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tttcacagggagacaaacaaGatgtactataaaattcttgg	8	6	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:20411884G>A	uc010tcn.1	-	6	1215	c.950C>T	c.(949-951)TCT>TTT	p.S317F	ZMYM5_uc001umm.1_Missense_Mutation_p.S141F|ZMYM5_uc001umn.2_Missense_Mutation_p.S317F|ZMYM5_uc001umo.2_3'UTR	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	317	MYM-type 2.					nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		AGACAAACAAGATGTACTATA	0.338													0	0	0	0.010729	0	10	48										A	20411884	G	A	20411884	3	1	39	1	0	0	0	0	1	0	0	0	17700	942	33	1	1182	1	ZMYM5	13	20411884	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		20411884	94757994	174	9577										
AKAP11	11215	broad.mit.edu	37	chr13	42874879	42874879	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	catggaggtgtgtcagttttCatatcctcaaacgcctgcat	9	10	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:42874879C>T	uc001uys.1	+	8	2172	c.1997C>T	c.(1996-1998)TCA>TTA	p.S666L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	666					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGTCAGTTTTCATATCCTCAA	0.403													0	0	0	0.00632	0	29	78										T	42874879	C	T	42874879	3	4	39	1	0	0	0	0	1	0	0	0	447	838	29	1	2019	1	AKAP11	13	42874879	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	22462995	42874879	72294999	175	9578										
MLNR	2862	broad.mit.edu	37	chr13	49796426	49796426	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaggcttccacagaagcagGgacactgcgggggaagttgc	16	9	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:49796426G>A	uc010tgj.1	+	2	1152	c.1152G>A	c.(1150-1152)AGG>AGA	p.R384R		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	384	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		ACAGAAGCAGGGACACTGCGG	0.567													0	0	0	0.00499	0	18	39										A	49796426	G	A	49796426	2	1	39	1	0	0	0	0	0	0	0	1	9632	1223	43	2		2	MLNR	13	49796426	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	6921547	49796426	65373452	176	9579										
RAP2A	5911	broad.mit.edu	37	chr13	98116619	98116619	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggtggacgaactctttgcaGaaattgtgaggcagatgaac	13	6	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:98116619G>A	uc001vnd.2	+	2	725	c.475G>A	c.(475-477)GAA>AAA	p.E159K		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	159					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			ACTCTTTGCAGAAATTGTGAG	0.478													0	0	0	0.027356	0	28	86										A	98116619	G	A	98116619	3	1	39	1	0	0	0	0	1	0	0	0	13040	943	33	1	481	1	RAP2A	13	98116619	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	48320193	98116619	17053259	177	9580										
MYH7	4625	broad.mit.edu	37	chr14	23884449	23884449	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtgggcgctggtgtcctgctCcttcttcagctcctctgcca	11	15	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:23884449C>G	uc001wjx.2	-	37	5420	c.5314G>C	c.(5314-5316)GAG>CAG	p.E1772Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1772	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GTGTCCTGCTCCTTCTTCAGC	0.602													0	0	0	0.021523	0	23	71										G	23884449	C	G	23884449	3	3	39	1	0	0	0	0	1	0	0	0	10039	864	30	1	509	1	MYH7	14	23884449	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		23884449	83465091	178	9581										
NFATC4	4776	broad.mit.edu	37	chr14	24843541	24843541	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgctctgcagcccagcgctCagcccaggagctgccccagg	12	18	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:24843541C>T	uc001wpc.2	+	6	2063	c.1742C>T	c.(1741-1743)TCA>TTA	p.S581L	NFATC4_uc010tok.1_Missense_Mutation_p.S644L|NFATC4_uc010tol.1_Missense_Mutation_p.S644L|NFATC4_uc010alr.2_Missense_Mutation_p.S644L|NFATC4_uc010als.2_3'UTR|NFATC4_uc010tom.1_Missense_Mutation_p.S594L|NFATC4_uc010ton.1_Missense_Mutation_p.S594L|NFATC4_uc010too.1_Missense_Mutation_p.S594L|NFATC4_uc010alt.2_Missense_Mutation_p.S613L|NFATC4_uc010top.1_Missense_Mutation_p.S613L|NFATC4_uc010toq.1_Missense_Mutation_p.S613L|NFATC4_uc010alu.2_3'UTR|NFATC4_uc010tor.1_Missense_Mutation_p.S581L|NFATC4_uc010tos.1_Missense_Mutation_p.S511L|NFATC4_uc010tot.1_Missense_Mutation_p.S569L|NFATC4_uc010tou.1_Missense_Mutation_p.S511L|NFATC4_uc010tov.1_Missense_Mutation_p.S569L|NFATC4_uc010tow.1_Missense_Mutation_p.S511L|NFATC4_uc010alv.2_Missense_Mutation_p.S569L|NFATC4_uc010tox.1_Missense_Mutation_p.S511L|NFATC4_uc001wpd.2_Missense_Mutation_p.S116L|NFATC4_uc010toy.1_Missense_Mutation_p.S116L|NFATC4_uc010toz.1_Missense_Mutation_p.S116L|NFATC4_uc010tpa.1_5'UTR|NFATC4_uc010tpb.1_5'UTR	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	581	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GCCCAGCGCTCAGCCCAGGAG	0.642													0	0	0	0.001984	0	6	13										T	24843541	C	T	24843541	3	4	39	1	0	0	0	0	1	0	0	0	10365	838	29	1	1957	1	NFATC4	14	24843541	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	959092	24843541	82505999	179	9582										
HECTD1	25831	broad.mit.edu	37	chr14	31613367	31613367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	caagccactgctacacatttCatatggtgaaattgtgtttt	7	8	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:31613367C>G	uc001wrc.1	-	17	3217	c.2728G>C	c.(2728-2730)GAA>CAA	p.E910Q	HECTD1_uc001wrd.1_Missense_Mutation_p.E425Q	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	910					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTACACATTTCATATGGTGAA	0.303													0	0	0	0.004482	0	8	16										G	31613367	C	G	31613367	3	3	39	1	0	0	0	0	1	0	0	0	7039	835	29	1	5212	1	HECTD1	14	31613367	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6769826	31613367	75736173	180	9583										
MIPOL1	145282	broad.mit.edu	37	chr14	37892073	37892073	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cttttaggcaaagttgttatCtatgcaacaagccagagaaa	8	7	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:37892073C>G	uc001wuc.2	+	12	1453	c.950C>G	c.(949-951)TCT>TGT	p.S317C	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Missense_Mutation_p.S286C|MIPOL1_uc001wud.2_Missense_Mutation_p.S317C|MIPOL1_uc010ams.2_Missense_Mutation_p.S317C|MIPOL1_uc001wue.2_Missense_Mutation_p.S286C|MIPOL1_uc010amt.2_Missense_Mutation_p.S136C	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	317	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAGTTGTTATCTATGCAACAA	0.323													0	0	0	0.004672	0	3	12										G	37892073	C	G	37892073	3	3	39	1	0	0	0	0	1	0	0	0	9593	913	32	1	984	1	MIPOL1	14	37892073	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6278706	37892073	69457467	181	9584										
PNN	5411	broad.mit.edu	37	chr14	39644553	39644553	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agagtcttaagaacgtggatGagaacattcgcaagctcacc	10	9	2	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:39644553G>A	uc001wuw.3	+	1	167	c.70G>A	c.(70-72)GAG>AAG	p.E24K		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	24	Potential.|Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.|Necessary for interactions with KRT8, KRT18 and KRT19.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GAACGTGGATGAGAACATTCG	0.577													0	0	0	0.021553	0	5	20										A	39644553	G	A	39644553	3	1	39	1	0	0	0	0	1	0	0	0	12160	1291	45	1	72	1	PNN	14	39644553	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1752480	39644553	67704987	182	9585										
SLC38A6	145389	broad.mit.edu	37	chr14	61517300	61517300	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gatgttgttgtcatgactgtGaagttatgcatactatttgc	10	5	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:61517300G>A	uc001xfg.1	+	13	1112	c.996G>A	c.(994-996)GTG>GTA	p.V332V	SLC38A6_uc001xfh.1_Silent_p.V332V|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Silent_p.V309V	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	332	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TCATGACTGTGAAGTTATGCA	0.343													0	0	0	0.010729	0	11	23										A	61517300	G	A	61517300	2	1	39	1	0	0	0	0	0	0	0	1	14608	1277	45	1		1	SLC38A6	14	61517300	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	21872747	61517300	45832240	183	9586										
SYNE2	23224	broad.mit.edu	37	chr14	64449432	64449432	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tcttagtcgaagtcagcaatGatgtggttggatcatctatt	10	6	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:64449432G>C	uc001xgm.2	+	17	2151	c.1921G>C	c.(1921-1923)GAT>CAT	p.D641H	SYNE2_uc001xgl.2_Missense_Mutation_p.D641H	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	641	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTCAGCAATGATGTGGTTGG	0.373													0	0	0	0.008361	0	30	43										C	64449432	G	C	64449432	3	2	39	1	0	0	0	0	1	0	0	0	15443	1290	45	1	1983	1	SYNE2	14	64449432	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2932132	64449432	42900108	184	9587										
KCNK10	54207	broad.mit.edu	37	chr14	88693731	88693731	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtactcactcgaaagaccttCtccactcttgcaatgctttt	5	13	3	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:88693731C>T	uc001xwo.2	-	4	1111	c.654G>A	c.(652-654)GAG>GAA	p.E218E	KCNK10_uc001xwm.2_Silent_p.E223E|KCNK10_uc001xwn.2_Silent_p.E223E	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	218	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GAAAGACCTTCTCCACTCTTG	0.428													0	0	0	0.008871	0	21	37										T	88693731	C	T	88693731	2	4	39	1	0	0	0	0	0	0	0	1	8059	912	32	1		1	KCNK10	14	88693731	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	24244299	88693731	18655809	185	9588										
KCNK10	54207	broad.mit.edu	37	chr14	88693853	88693853	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acaaaagattttgcctccttCagtgctcggagcaatattcc	7	11	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:88693853C>T	uc001xwo.2	-	4	989	c.532G>A	c.(532-534)GAA>AAA	p.E178K	KCNK10_uc001xwm.2_Missense_Mutation_p.E183K|KCNK10_uc001xwn.2_Missense_Mutation_p.E183K	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	178					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TTGCCTCCTTCAGTGCTCGGA	0.403													0	0	0	0.01892	0	25	63										T	88693853	C	T	88693853	3	4	39	1	0	0	0	0	1	0	0	0	8059	835	29	1	1100	1	KCNK10	14	88693853	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	122	88693853	18655687	186	9589										
CDC42BPB	9578	broad.mit.edu	37	chr14	103416915	103416915	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggggggcaccgtctttgcagGacacgtggcaagcaaaggaa	16	9	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:103416915G>T	uc001ymi.1	-	25	3429	c.3197C>A	c.(3196-3198)TCC>TAC	p.S1066Y	CDC42BPB_uc001ymj.1_Missense_Mutation_p.S168Y	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1066	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GTCTTTGCAGGACACGTGGCA	0.572													1	0	1.96292e-10	0.010504	2.08956e-10	20	31										T	103416915	G	T	103416915	3	4	39	1	0	0	0	0	1	0	0	0	3073	1174	41	3	1990	3	CDC42BPB	14	103416915	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	14723062	103416915	3932625	187	9590										
TJP1	7082	broad.mit.edu	37	chr15	30019056	30019056	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	acttcctggcacttttccgaGattctggacataacctcatt	6	12	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:30019056G>A	uc001zcr.2	-	17	2715	c.2240C>T	c.(2239-2241)TCT>TTT	p.S747F	TJP1_uc010azl.2_Missense_Mutation_p.S735F|TJP1_uc001zcq.2_Missense_Mutation_p.S751F|TJP1_uc001zcs.2_Missense_Mutation_p.S747F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	747	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ACTTTTCCGAGATTCTGGACA	0.363													0	0	0	0.00874	0	42	67										A	30019056	G	A	30019056	3	1	39	1	0	0	0	0	1	0	0	0	15926	942	33	1	3054	1	TJP1	15	30019056	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		30019056	72512336	188	9591										
RYR3	6263	broad.mit.edu	37	chr15	34078093	34078093	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctgcaccaaggtcacctctGaacacctcagtctcatcctg	7	16	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:34078093G>A	uc001zhi.2	+	66	9569	c.9499G>A	c.(9499-9501)GAA>AAA	p.E3167K	RYR3_uc010bar.2_Missense_Mutation_p.E3167K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3167					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGTCACCTCTGAACACCTCAG	0.562													0	0	0	0.01441	0	57	88										A	34078093	G	A	34078093	3	1	39	1	0	0	0	0	1	0	0	0	13770	1291	45	1	9761	1	RYR3	15	34078093	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4059037	34078093	68453299	189	9592										
BUB1B	701	broad.mit.edu	37	chr15	40475992	40475992	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggaggaagtttttgagtcttCtgtaccacaacgaagcacac	10	9	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:40475992C>G	uc001zkx.3	+	6	871	c.659C>G	c.(658-660)TCT>TGT	p.S220C	BUB1B_uc010ucl.1_Missense_Mutation_p.S83C	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	220	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTTGAGTCTTCTGTACCACAA	0.448			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.021523	0	26	27										G	40475992	C	G	40475992	3	3	39	1	0	0	0	0	1	0	0	0	1571	913	32	1	681	1	BUB1B	15	40475992	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6397899	40475992	62055400	190	9593										
SHC4	399694	broad.mit.edu	37	chr15	49148320	49148320	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gctatcaatatgcacctcctCactgtgaaggaaaaaagaat	7	9	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:49148320C>A	uc001zxb.1	-	8	1501	c.1072G>T	c.(1072-1074)GAG>TAG	p.E358*	SHC4_uc010uey.1_Nonsense_Mutation_p.E115*|SHC4_uc010uez.1_Nonsense_Mutation_p.E72*	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	358	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TGCACCTCCTCACTGTGAAGG	0.428													1	0	4.47668e-21	0.021523	4.85955e-21	27	54										A	49148320	C	A	49148320	4	1	39	1	0	0	0	0	0	1	0	0	14273	840	29	3	840	3	SHC4	15	49148320	Nonsense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	8672328	49148320	53383072	191	9594										
HERC1	8925	broad.mit.edu	37	chr15	63908120	63908120	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaagaatcaagaggaatcatCtaggaacagaagaaaacaga	9	5	3	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:63908120C>G	uc002amp.2	-	76	14090	c.13942_splice	c.e76-1	p.M4648_splice		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GAGGAATCATCTAGGAACAGA	0.358													0	0	0	0.004672	0	3	4										G	63908120	C	G	63908120	5	3	39	1	0	0	0	0	0	0	1	0	7057	927	32	1	656	1	HERC1	15	63908120	Splice_Site	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	14759800	63908120	38623272	192	9595										
ACAN	176	broad.mit.edu	37	chr15	89392692	89392692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggtgttcttcgccacacgcCttgagcagttcaccttccag	9	14	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:89392692C>T	uc010upo.1	+	10	2130	c.1756C>T	c.(1756-1758)CTT>TTT	p.L586F	ACAN_uc002bmx.2_Missense_Mutation_p.L586F|ACAN_uc010upp.1_Missense_Mutation_p.L586F|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	586					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CGCCACACGCCTTGAGCAGTT	0.632													0	0	0	0.001984	0	6	8										T	89392692	C	T	89392692	3	4	39	1	0	0	0	0	1	0	0	0	117	681	24	2	1790	2	ACAN	15	89392692	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	25484572	89392692	13138700	193	9596										
CREBBP	1387	broad.mit.edu	37	chr16	3788651	3788651	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccggaagaaatgaatactatCcagataagaaatgtacacac	7	8	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:3788651C>G	uc002cvv.2	-	26	4507	c.4303G>C	c.(4303-4305)GAT>CAT	p.D1435H	CREBBP_uc002cvw.2_Missense_Mutation_p.D1397H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1435	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1435G(1)|p.D1435E(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGAATACTATCCAGATAAGAA	0.433			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.014758	0	5	10										G	3788651	C	G	3788651	3	3	39	1	0	0	0	0	1	0	0	0	3861	855	30	1	3049	1	CREBBP	16	3788651	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		3788651	86566102	194	9597										
UBN1	29855	broad.mit.edu	37	chr16	4924401	4924401	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggaggactcattggatgaaGacttgatccgcaatccagcc	11	10	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:4924401G>A	uc002cyb.2	+	15	2329	c.1990G>A	c.(1990-1992)GAC>AAC	p.D664N	UBN1_uc010uxw.1_Missense_Mutation_p.D664N|UBN1_uc002cyc.2_Missense_Mutation_p.D664N	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	664					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ATTGGATGAAGACTTGATCCG	0.577													0	0	0	0.021022	0	40	102										A	4924401	G	A	4924401	3	1	39	1	0	0	0	0	1	0	0	0	16889	942	33	1	2044	1	UBN1	16	4924401	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1135750	4924401	85430352	195	9598										
SMG1	23049	broad.mit.edu	37	chr16	18841068	18841068	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagtattctgatcttcaagtGaacttgatcctacaaaaagg	7	8	3	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:18841068G>A	uc002dfm.2	-	54	9506	c.9143C>T	c.(9142-9144)TCA>TTA	p.S3048L	SMG1_uc010bwb.2_Missense_Mutation_p.S2908L|SMG1_uc010bwa.2_Missense_Mutation_p.S1779L	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3048					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ATCTTCAAGTGAACTTGATCC	0.323													0	0	0	0.020292	0	14	15										A	18841068	G	A	18841068	3	1	39	1	0	0	0	0	1	0	0	0	14795	1294	45	1	1882	1	SMG1	16	18841068	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	13916667	18841068	71513685	196	9599										
RBL2	5934	broad.mit.edu	37	chr16	53524211	53524211	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	taatgaccgtggttcccactGaggttagtctcttgtattaa	9	8	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:53524211G>A	uc002ehi.3	+	22	3537	c.3419G>A	c.(3418-3420)TGA>TAA	p.*1140*	RBL2_uc002ehj.2_Silent_p.*850*|RBL2_uc010vgw.1_Silent_p.*519*	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1140					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GGTTCCCACTGAGGTTAGTCT	0.403													0	0	0	0.028581	0	16	36										A	53524211	G	A	53524211	2	1	39	1	0	0	0	0	0	0	0	1	13110	1285	45	1		1	RBL2	16	53524211	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	34683143	53524211	36830542	197	9600										
SLC9A5	6553	broad.mit.edu	37	chr16	67291253	67291253	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cctgcctgtccatagggcttGaccatcaagccactggtcaa	9	14	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:67291253G>C	uc002esm.2	+	8	1404	c.1341G>C	c.(1339-1341)TTG>TTC	p.L447F	SLC9A5_uc010cee.2_Missense_Mutation_p.L152F|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	447	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CATAGGGCTTGACCATCAAGC	0.542													0	0	0	0.013537	0	13	39										C	67291253	G	C	67291253	3	2	39	1	0	0	0	0	1	0	0	0	14717	1281	45	1	1371	1	SLC9A5	16	67291253	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	13767042	67291253	23063500	198	9601										
KCTD19	146212	broad.mit.edu	37	chr16	67324842	67324842	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cggtcatccttgaagccggtGatggccagcaaatctaccac	10	13	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:67324842G>A	uc002esu.2	-	15	2664	c.2613C>T	c.(2611-2613)ATC>ATT	p.I871I	KCTD19_uc002est.2_Silent_p.I643I|KCTD19_uc010vjj.1_Silent_p.I614I	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	871						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TGAAGCCGGTGATGGCCAGCA	0.617													0	0	0	0.021553	0	4	10										A	67324842	G	A	67324842	2	1	39	1	0	0	0	0	0	0	0	1	8106	1280	45	1		1	KCTD19	16	67324842	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	33589	67324842	23029911	199	9602										
PRMT7	54496	broad.mit.edu	37	chr16	68373809	68373809	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gggacattgaaatggaccctGaggggaagatcaagtgcacc	14	8	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:68373809G>C	uc002evy.1	+	9	1141	c.865G>C	c.(865-867)GAG>CAG	p.E289Q	PRMT7_uc002evx.1_Missense_Mutation_p.E289Q|PRMT7_uc010vlg.1_Missense_Mutation_p.E239Q|PRMT7_uc002evz.1_Missense_Mutation_p.E135Q	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	289					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		AATGGACCCTGAGGGGAAGAT	0.572													0	0	0	0.028581	0	17	20										C	68373809	G	C	68373809	3	2	39	1	0	0	0	0	1	0	0	0	12541	1291	45	1	891	1	PRMT7	16	68373809	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1048967	68373809	21980944	200	9603										
PHLPP2	23035	broad.mit.edu	37	chr16	71718490	71718490	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcaagggagtattgccgtcgCttcacttcttctatctgaag	10	10	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:71718490C>G	uc002fax.2	-	4	630	c.624G>C	c.(622-624)AAG>AAC	p.K208N	PHLPP2_uc002fav.2_5'Flank|PHLPP2_uc010cgf.2_Missense_Mutation_p.K208N|PHLPP2_uc002fay.1_Missense_Mutation_p.K208N	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	208	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						ATTGCCGTCGCTTCACTTCTT	0.473													0	0	0	0.001984	0	7	18										G	71718490	C	G	71718490	3	3	39	1	0	0	0	0	1	0	0	0	11855	796	28	4	3407	4	PHLPP2	16	71718490	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3344681	71718490	18636263	201	9604										
ZFHX3	463	broad.mit.edu	37	chr16	72831063	72831063	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atggctctgctgtgggacctGaacctgagccttcagatctt	11	11	3	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:72831063G>C	uc002fck.2	-	9	6191	c.5518C>G	c.(5518-5520)CAG>GAG	p.Q1840E	ZFHX3_uc002fcl.2_Missense_Mutation_p.Q926E	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1840					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TGTGGGACCTGAACCTGAGCC	0.592													0	0	0	0.00632	0	30	37										C	72831063	G	C	72831063	3	2	39	1	0	0	0	0	1	0	0	0	17631	1299	45	1	5601	1	ZFHX3	16	72831063	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1112573	72831063	17523690	202	9605										
TMEM231	79583	broad.mit.edu	37	chr16	75579304	75579304	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggctgcttctgctgcagcctCaggtctccgttcacgtataa	10	13	4	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:75579304C>G	uc002fem.2	-	4	591	c.528G>C	c.(526-528)CTG>CTC	p.L176L	CHST5_uc002fej.1_5'UTR|TMEM231_uc002fek.2_Silent_p.L205L|TMEM231_uc002fel.2_Silent_p.L60L|TMEM231_uc010vne.1_Silent_p.L29L|TMEM231_uc010cgx.1_Silent_p.L140L	NM_001077418	NP_001070886	Q9H6L2	TM231_HUMAN	transmembrane protein 231 isoform 2	176						integral to membrane					0						GCTGCAGCCTCAGGTCTCCGT	0.542													0	0	0	0.01441	0	39	47										G	75579304	C	G	75579304	2	3	39	1	0	0	0	0	0	0	0	1	16146	813	29	1		1	TMEM231	16	75579304	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	2748241	75579304	14775449	203	9606										
KARS	3735	broad.mit.edu	37	chr16	75663370	75663370	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggatcattcagctcagtataCgcattgcatatctctttctt	6	10	5	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:75663370C>T	uc002feq.2	-	12	1542	c.1494G>A	c.(1492-1494)GCG>GCA	p.A498A	KARS_uc002fer.2_Silent_p.A526A|KARS_uc002fes.2_Silent_p.A342A	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	498					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding	p.A498A(1)		ovary(2)	2					L-Lysine(DB00123)	GCTCAGTATACGCATTGCATA	0.517													0	0	0	0.019004	0	36	69										T	75663370	C	T	75663370	2	4	39	1	0	0	0	0	0	0	0	1	7980	523	19	2		2	KARS	16	75663370	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	84066	75663370	14691383	204	9607										
SPIRE2	84501	broad.mit.edu	37	chr16	89929916	89929916	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cccgtggagagcctggcgctGactgtggaagaggtgatgga	18	8	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:89929916G>C	uc002foz.1	+	11	1660	c.1608G>C	c.(1606-1608)CTG>CTC	p.L536L	SPIRE2_uc010ciw.1_Silent_p.L536L|SPIRE2_uc002fpa.1_Silent_p.L488L|SPIRE2_uc010cix.1_Silent_p.L403L	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	536	Spir-box.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GCCTGGCGCTGACTGTGGAAG	0.572													0	0	0	0.010729	0	11	24										C	89929916	G	C	89929916	2	2	39	1	0	0	0	0	0	0	0	1	15071	1277	45	1		1	SPIRE2	16	89929916	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	14266546	89929916	424837	205	9608										
SRR	63826	broad.mit.edu	37	chr17	2222158	2222158	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggtgccccagacagctccaGactgtaaaaaacttgcaata	8	11	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:2222158G>C	uc002fue.1	+	4	402	c.334G>C	c.(334-336)GAC>CAC	p.D112H	SRR_uc002fui.1_5'UTR	NM_021947	NP_068766	Q9GZT4	SRR_HUMAN	serine racemase	112					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity				0		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GACAGCTCCAGACTGTAAAAA	0.423													0	0	0	0.01441	0	79	33										C	2222158	G	C	2222158	3	2	39	1	0	0	0	0	1	0	0	0	15165	942	33	1	344	1	SRR	17	2222158	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		2222158	78973052	206	9609										
ATP2A3	489	broad.mit.edu	37	chr17	3854917	3854917	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttggccacgaggatcagcatGatgaccaggggctccacgaa	13	11	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:3854917G>A	uc002fxb.1	-	4	433	c.282C>T	c.(280-282)ATC>ATT	p.I94I	ATP2A3_uc002fwx.1_Silent_p.I94I|ATP2A3_uc002fwy.1_Silent_p.I94I|ATP2A3_uc002fwz.1_Silent_p.I94I|ATP2A3_uc002fxa.1_Silent_p.I94I|ATP2A3_uc002fxc.1_Silent_p.I94I|ATP2A3_uc002fxd.1_Silent_p.I94I	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	94	Helical; Name=2; (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGATCAGCATGATGACCAGGG	0.687													0	0	0	0.006214	0	9	4										A	3854917	G	A	3854917	2	1	39	1	0	0	0	0	0	0	0	1	1138	1280	45	1		1	ATP2A3	17	3854917	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1632759	3854917	77340293	207	9610										
NCOR1	9611	broad.mit.edu	37	chr17	15960870	15960870	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gattttctggagagacccttGaacctggtctttgatgatgg	12	7	2	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15960870G>C	uc002gpo.2	-	40	6590	c.6350C>G	c.(6349-6351)TCA>TGA	p.S2117*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.S2014*|NCOR1_uc002gpl.2_Nonsense_Mutation_p.S132*|NCOR1_uc002gpm.2_Nonsense_Mutation_p.S637*|NCOR1_uc010vwb.1_Nonsense_Mutation_p.S701*|NCOR1_uc010coy.2_Nonsense_Mutation_p.S1025*|NCOR1_uc010vwc.1_Nonsense_Mutation_p.S927*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2117	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGAGACCCTTGAACCTGGTCT	0.408													0	0	0	0.015359	0	33	62										C	15960870	G	C	15960870	4	2	39	1	0	0	0	0	0	1	0	0	10235	1294	45	1	1000	1	NCOR1	17	15960870	Nonsense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12105953	15960870	65234340	208	9611			1	38		3	3	925	G		3.226505e-05
NCOR1	9611	broad.mit.edu	37	chr17	15960927	15960927	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	attctgggctgtaacggtttGatgttttagtcctcacaggt	11	7	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15960927G>A	uc002gpo.2	-	40	6533	c.6293C>T	c.(6292-6294)TCA>TTA	p.S2098L	NCOR1_uc002gpn.2_Missense_Mutation_p.S1995L|NCOR1_uc002gpl.2_Missense_Mutation_p.S113L|NCOR1_uc002gpm.2_Missense_Mutation_p.S618L|NCOR1_uc010vwb.1_Missense_Mutation_p.S682L|NCOR1_uc010coy.2_Missense_Mutation_p.S1006L|NCOR1_uc010vwc.1_Missense_Mutation_p.S908L	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2098	Interaction with C1D (By similarity).|ID1 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTAACGGTTTGATGTTTTAGT	0.483													0	0	0	0.014323	0	22	50										A	15960927	G	A	15960927	3	1	39	1	0	0	0	0	1	0	0	0	10235	1294	45	1	1057	1	NCOR1	17	15960927	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	57	15960927	65234283	209	9612			1	38		3	3	925	G		3.226505e-05
NCOR1	9611	broad.mit.edu	37	chr17	15961794	15961794	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agaagacatactttccgcttGatttgccttaacaacctctg	6	11	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15961794G>C	uc002gpo.2	-	38	6241	c.6001C>G	c.(6001-6003)CAA>GAA	p.Q2001E	NCOR1_uc002gpn.2_Missense_Mutation_p.Q1898E|NCOR1_uc002gpl.2_5'Flank|NCOR1_uc002gpm.2_Missense_Mutation_p.Q521E|NCOR1_uc010vwb.1_Missense_Mutation_p.Q585E|NCOR1_uc010coy.2_Missense_Mutation_p.Q909E|NCOR1_uc010vwc.1_Missense_Mutation_p.Q811E	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2001	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTTCCGCTTGATTTGCCTTA	0.413													0	0	0	0.00632	0	26	60										C	15961794	G	C	15961794	3	2	39	1	0	0	0	0	1	0	0	0	10235	1299	45	1	1357	1	NCOR1	17	15961794	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	867	15961794	65233416	210	9613			1	38		3	3	925	G		3.226505e-05
RAI1	10743	broad.mit.edu	37	chr17	17700785	17700785	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggaggagctgggcctggcctCccagcccccggagggcaggc	18	15	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:17700785C>T	uc002grm.2	+	3	4992	c.4523C>T	c.(4522-4524)TCC>TTC	p.S1508F	RAI1_uc002grn.1_Missense_Mutation_p.S1508F	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1508						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GGCCTGGCCTCCCAGCCCCCG	0.642													0	0	0	0.00632	0	29	6										T	17700785	C	T	17700785	3	4	39	1	0	0	0	0	1	0	0	0	13007	855	30	1	4525	1	RAI1	17	17700785	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1738991	17700785	63494425	211	9614										
NLK	51701	broad.mit.edu	37	chr17	26518092	26518092	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccttagcccacccctacctaGatgaagggcgactacgatat	8	14	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:26518092G>C	uc010crj.2	+	9	1494	c.1282G>C	c.(1282-1284)GAT>CAT	p.D428H	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	428					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CCCCTACCTAGATGAAGGGCG	0.438													0	0	0	0.014323	0	21	70										C	26518092	G	C	26518092	3	2	39	1	0	0	0	0	1	0	0	0	10466	942	33	1	1316	1	NLK	17	26518092	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	8817307	26518092	54677118	212	9615										
SRCIN1	80725	broad.mit.edu	37	chr17	36704795	36704795	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aggtgtgccctgacctacctCtagctctgcgatgatgcgat	11	12	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:36704795C>G	uc002hqd.2	-	17	3493	c.3268G>C	c.(3268-3270)GAG>CAG	p.E1090Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.E962Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.E944Q	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	962					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						TGACCTACCTCTAGCTCTGCG	0.662													0	0	0	0.010504	0	22	58										G	36704795	C	G	36704795	3	3	39	1	0	0	0	0	1	0	0	0	15135	922	32	1	295	1	SRCIN1	17	36704795	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	10186703	36704795	44490415	213	9616										
ERBB2	2064	broad.mit.edu	37	chr17	37880220	37880220	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tccagtggccatcaaagtgtTgagggaaaacacatccccca	9	12	1	1	rs121913470		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:37880220T>C	uc002hso.2	+	19	2502	c.2264T>C	c.(2263-2265)TTG>TCG	p.L755S	ERBB2_uc002hsm.2_Missense_Mutation_p.L725S|ERBB2_uc010cwa.2_Missense_Mutation_p.L740S|ERBB2_uc002hsp.2_Missense_Mutation_p.L558S|ERBB2_uc010cwb.2_Missense_Mutation_p.L755S|ERBB2_uc010wek.1_Missense_Mutation_p.L479S	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	755	Cytoplasmic (Potential).|Protein kinase.		L -> P (in a lung adenocarcinoma sample; somatic mutation).		cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L755S(4)|p.L755P(2)|p.L755_S760>A(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCAAAGTGTTGAGGGAAAAC	0.532	L755S(LN229_CENTRAL_NERVOUS_SYSTEM)	1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.024245	0	16	22										C	37880220	T	C	37880220	3	2	39	1	0	0	0	0	1	0	0	0	5206	1821	63	5	2338	5	ERBB2	17	37880220	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	1175425	37880220	43314990	214	9617										
JUP	3728	broad.mit.edu	37	chr17	39680110	39680111	+	Frame_Shift_Ins	INS	-	-	A													0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gatgtccatgagccgctggtINSactcctgattctgccgctca							TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:39680110_39680111insA	uc010wfs.1	-	9	1584_1585	c.1576_1577insT	c.(1576-1578)TACfs	p.Y526fs	KRT15_uc002hxb.1_5'Flank|uc002hxc.1_5'Flank|KRT19_uc002hxd.3_Frame_Shift_Ins_p.Y363fs	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GAGCCGCTGGTACTCCTGATTC	0.589																		13	61	---	---								A	39680111	-	A	39680110	7	5	39	1	0	1	1	0	0	0	0	0	7972	1638	57	0		0	JUP	17	39680110	Frame_Shift_Ins	INS	-	TCGA-CU-A3YL-01A-11D-A22Z-08	1799890	39680110	41515100	215	9618										
SLC25A39	51629	broad.mit.edu	37	chr17	42400878	42400878	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	taaccacagccccggtgcctGaggccaccatttgctggagg	12	14	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:42400878G>A	uc002ign.2	-	2	207	c.53C>T	c.(52-54)TCA>TTA	p.S18L	SLC25A39_uc002igm.2_Missense_Mutation_p.S18L|SLC25A39_uc002igo.2_Missense_Mutation_p.S18L|SLC25A39_uc010wiw.1_Missense_Mutation_p.S18L|SLC25A39_uc010czu.2_Intron|SLC25A39_uc010wix.1_Missense_Mutation_p.S18L|SLC25A39_uc010wiy.1_Missense_Mutation_p.S18L	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	18	Solcar 1.|Helical; Name=1; (Potential).				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCCGGTGCCTGAGGCCACCAT	0.607													0	0	0	0.004672	0	3	3										A	42400878	G	A	42400878	3	1	39	1	0	0	0	0	1	0	0	0	14503	1294	45	1	1070	1	SLC25A39	17	42400878	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2720768	42400878	38794332	216	9619										
TTLL6	284076	broad.mit.edu	37	chr17	46862467	46862467	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggcctcctccgtgggagcctCctggttgaggctgctgtctg	15	13	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:46862467C>A	uc010wlo.1	-	14	1893	c.1858G>T	c.(1858-1860)GAG>TAG	p.E620*	TTLL6_uc002iob.2_Nonsense_Mutation_p.E313*|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Nonsense_Mutation_p.E373*|TTLL6_uc002iod.2_Nonsense_Mutation_p.E467*	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	572						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						GTGGGAGCCTCCTGGTTGAGG	0.507													1	0	2.68985e-26	0.01441	2.92954e-26	49	100										A	46862467	C	A	46862467	4	1	39	1	0	0	0	0	0	1	0	0	16728	864	30	3	829	3	TTLL6	17	46862467	Nonsense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	4461589	46862467	34332743	217	9620										
TTLL6	284076	broad.mit.edu	37	chr17	46862485	46862485	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctcctggttgaggctgctgtCtgtttcatttttcctttcac	8	11	3	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:46862485C>T	uc010wlo.1	-	14	1875	c.1840G>A	c.(1840-1842)GAC>AAC	p.D614N	TTLL6_uc002iob.2_Missense_Mutation_p.D307N|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.D367N|TTLL6_uc002iod.2_Missense_Mutation_p.D461N	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	566						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						AGGCTGCTGTCTGTTTCATTT	0.512													0	0	0	0.013114	0	48	96										T	46862485	C	T	46862485	3	4	39	1	0	0	0	0	1	0	0	0	16728	913	32	1	847	1	TTLL6	17	46862485	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	18	46862485	34332725	218	9621										
SPOP	8405	broad.mit.edu	37	chr17	47688672	47688672	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agccttgtgagcctggaattCctggccggcaacacacaagc	11	13	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:47688672C>G	uc010dbk.2	-	7	1260	c.628G>C	c.(628-630)GAA>CAA	p.E210Q	SPOP_uc002ipb.2_Missense_Mutation_p.E210Q|SPOP_uc002ipc.2_Missense_Mutation_p.E210Q|SPOP_uc002ipd.2_Missense_Mutation_p.E210Q|SPOP_uc002ipe.2_Missense_Mutation_p.E210Q|SPOP_uc002ipf.2_Missense_Mutation_p.E210Q|SPOP_uc002ipg.2_Missense_Mutation_p.E210Q	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	210	BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						GCCTGGAATTCCTGGCCGGCA	0.453										Prostate(2;0.17)			0	0	0	0.01441	0	77	94										G	47688672	C	G	47688672	3	3	39	1	0	0	0	0	1	0	0	0	15083	864	30	1	516	1	SPOP	17	47688672	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	826187	47688672	33506538	219	9622										
NOG	9241	broad.mit.edu	37	chr17	54671875	54671875	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggcgggggtgcagctgggggCgcggaggacctggcggagct	24	9	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:54671875C>A	uc002iup.2	+	1	816	c.291C>A	c.(289-291)GGC>GGA	p.G97G		NM_005450	NP_005441	Q13253	NOGG_HUMAN	noggin precursor	97					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity				0	Breast(9;5.24e-08)					CAGCTGGGGGCGCGGAGGACC	0.647													1	0	0.000274275	0.004482	0.000282846	9	7										A	54671875	C	A	54671875	2	1	39	1	0	0	0	0	0	0	0	1	10519	755	27	4		4	NOG	17	54671875	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6983203	54671875	26523335	220	9623										
C17orf71	55181	broad.mit.edu	37	chr17	57288781	57288781	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagcagcttcaaaactgtatGaggtggctattgatgggaaa	12	6	1	2	rs5821255		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:57288781G>C	uc002ixi.2	+	1	1411	c.1369G>C	c.(1369-1371)GAG>CAG	p.E457Q		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	457					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					AAAACTGTATGAGGTGGCTAT	0.438													0	0	0	0.009718	0	44	64										C	57288781	G	C	57288781	3	2	39	1	0	0	0	0	1	0	0	0	1878	1291	45	1	1371	1	C17orf71	17	57288781	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2616906	57288781	23906429	221	9624										
USP32	84669	broad.mit.edu	37	chr17	58288867	58288867	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tagacctgtggctcccttttCtgtgggaactggaacaaaca	10	10	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:58288867C>G	uc002iyo.1	-	20	2474	c.2188G>C	c.(2188-2190)GAA>CAA	p.E730Q	USP32_uc002iyn.1_Missense_Mutation_p.E400Q	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	730					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GCTCCCTTTTCTGTGGGAACT	0.383													0	0	0	0.009718	0	39	126										G	58288867	C	G	58288867	3	3	39	1	0	0	0	0	1	0	0	0	17060	922	32	1	2686	1	USP32	17	58288867	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1000086	58288867	22906343	222	9625										
USP32	84669	broad.mit.edu	37	chr17	58289433	58289433	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgctataaaagacatctcctCaggccaactcatatctttgt	5	11	4	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:58289433C>G	uc002iyo.1	-	19	2417	c.2131G>C	c.(2131-2133)GAG>CAG	p.E711Q	USP32_uc002iyn.1_Missense_Mutation_p.E381Q	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	711					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GACATCTCCTCAGGCCAACTC	0.289													0	0	0	0.010729	0	10	43										G	58289433	C	G	58289433	3	3	39	1	0	0	0	0	1	0	0	0	17060	835	29	1	2747	1	USP32	17	58289433	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	566	58289433	22905777	223	9626										
INTS2	57508	broad.mit.edu	37	chr17	59946642	59946642	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aatgctcattacctgtttctCaagttctggctgtgcaataa	7	9	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:59946642C>G	uc002izn.2	-	22	3230	c.3154G>C	c.(3154-3156)GAG>CAG	p.E1052Q	INTS2_uc002izm.2_Missense_Mutation_p.E1044Q	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	1052					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						ACCTGTTTCTCAAGTTCTGGC	0.378													0	0	0	0.016723	0	14	14										G	59946642	C	G	59946642	3	3	39	1	0	0	0	0	1	0	0	0	7778	835	29	1	476	1	INTS2	17	59946642	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1657209	59946642	21248568	224	9627										
TANC2	26115	broad.mit.edu	37	chr17	61499280	61499280	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	caagggcagacatcccctatCaaaccaaagagaccgttcgt	8	13	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:61499280C>G	uc002jal.3	+	25	5960	c.5937C>G	c.(5935-5937)ATC>ATG	p.I1979M	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Missense_Mutation_p.I1090M	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1979							binding			ovary(2)	2						CATCCCCTATCAAACCAAAGA	0.498													0	0	0	0.024334	0	28	40										G	61499280	C	G	61499280	3	3	39	1	0	0	0	0	1	0	0	0	15542	816	29	1	6035	1	TANC2	17	61499280	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1552638	61499280	19695930	225	9628										
MFSD11	79157	broad.mit.edu	37	chr17	74737112	74737112	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggttgccattgtaggacctCaactctctatgtttgccagt	9	10	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:74737112C>T	uc002jta.2	+	4	1199	c.226C>T	c.(226-228)CAA>TAA	p.Q76*	MFSD11_uc002jtb.2_Nonsense_Mutation_p.Q76*|MFSD11_uc010dha.2_Nonsense_Mutation_p.Q76*|MFSD11_uc002jtc.2_Nonsense_Mutation_p.Q76*|MFSD11_uc002jtd.3_Nonsense_Mutation_p.Q76*|MFSD11_uc010dhb.2_Nonsense_Mutation_p.Q76*|MFSD11_uc002jte.2_Nonsense_Mutation_p.Q76*	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	76	Helical; (Potential).					integral to membrane				ovary(1)	1						TGTAGGACCTCAACTCTCTAT	0.373													0	0	0	0.01441	0	58	96										T	74737112	C	T	74737112	4	4	39	1	0	0	0	0	0	1	0	0	9529	827	29	1	236	1	MFSD11	17	74737112	Nonsense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	13237832	74737112	6458098	226	9629										
RNF213	57674	broad.mit.edu	37	chr17	78318559	78318559	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccaaagaggtgatagacatgGagctgagtgccctgaggagt	15	7	0	5			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:78318559G>A	uc002jyh.1	+	4	866	c.643G>A	c.(643-645)GAG>AAG	p.E215K		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GATAGACATGGAGCTGAGTGC	0.488													0	0	0	0.01441	0	81	125										A	78318559	G	A	78318559	3	1	39	1	0	0	0	0	1	0	0	0	13477	1175	41	1	6853	1	RNF213	17	78318559	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	3581447	78318559	2876651	227	9630										
SLC14A1	6563	broad.mit.edu	37	chr18	43328388	43328388	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcatggcaaactttatggctGaggtgagtttgctttagtct	12	6	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:43328388G>C	uc010xcn.1	+	10	1313	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	SLC14A1_uc010dnk.2_Missense_Mutation_p.E388Q|SLC14A1_uc002lbf.3_Missense_Mutation_p.E332Q|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.E227Q|SLC14A1_uc002lbh.3_Missense_Mutation_p.E224Q|SLC14A1_uc002lbi.3_Missense_Mutation_p.E200Q|SLC14A1_uc002lbj.3_Missense_Mutation_p.E388Q|SLC14A1_uc002lbk.3_Missense_Mutation_p.E332Q	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	332						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						CTTTATGGCTGAGGTGAGTTT	0.448													0	0	0	0.014323	0	24	52										C	43328388	G	C	43328388	3	2	39	1	0	0	0	0	1	0	0	0	14396	1291	45	1	1192	1	SLC14A1	18	43328388	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		43328388	34748860	228	9631										
SERPINB8	5271	broad.mit.edu	37	chr18	61647088	61647088	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cgaggtttccagtcacttctCagtgaagttaacagaactgg	10	9	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:61647088C>T	uc002ljv.2	+	3	391	c.222C>T	c.(220-222)CTC>CTT	p.L74L	SERPINB8_uc002ljs.1_Silent_p.L74L|SERPINB8_uc002ljt.2_Silent_p.L74L|SERPINB8_uc002lju.2_Silent_p.L74L|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	74					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				AGTCACTTCTCAGTGAAGTTA	0.418											OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.027894	0	40	71										T	61647088	C	T	61647088	2	4	39	1	0	0	0	0	0	0	0	1	14107	813	29	1		1	SERPINB8	18	61647088	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	18318700	61647088	16430160	229	9632										
SOCS6	9306	broad.mit.edu	37	chr18	67992983	67992983	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggttgcaagagtttatgactCagtgcaaagtagtggtccca	12	7	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:67992983C>T	uc002lkr.1	+	2	1395	c.1079C>T	c.(1078-1080)TCA>TTA	p.S360L	SOCS6_uc010dqq.2_Missense_Mutation_p.S360L	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	360					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GTTTATGACTCAGTGCAAAGT	0.493													0	0	0	0.020292	0	15	37										T	67992983	C	T	67992983	3	4	39	1	0	0	0	0	1	0	0	0	14918	838	29	1	1081	1	SOCS6	18	67992983	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6345895	67992983	10084265	230	9633										
MIDN	90007	broad.mit.edu	37	chr19	1255046	1255046	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tcacgccccgggggtcttctCagggaccttctctggtaggt	13	13	4	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:1255046C>G	uc002lrp.2	+	6	1357	c.842C>G	c.(841-843)TCA>TGA	p.S281*		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	281						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGTCTTCTCAGGGACCTTC	0.637													0	0	0	0.008871	0	18	65										G	1255046	C	G	1255046	4	3	39	1	0	0	0	0	0	1	0	0	9579	838	29	1	860	1	MIDN	19	1255046	Nonsense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		1255046	57873937	231	9634										
LRG1	116844	broad.mit.edu	37	chr19	4538815	4538815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggcaggtagccggggatttCggcaggtggttgacaggaga	19	6	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:4538815C>T	uc002mau.2	-	2	192	c.181G>A	c.(181-183)GAA>AAA	p.E61K	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	61						extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGGATTTCGGCAGGTGGT	0.637													0	0	0	0.021553	0	6	61										T	4538815	C	T	4538815	3	4	39	1	0	0	0	0	1	0	0	0	8942	893	31	1	866	1	LRG1	19	4538815	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	3283769	4538815	54590168	232	9635										
KRI1	65095	broad.mit.edu	37	chr19	10670361	10670361	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttacggcgcacggaggacgcGatgctgcgtgggtaggtctt	17	9	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:10670361G>C	uc002moy.1	-	11	978	c.969C>G	c.(967-969)ATC>ATG	p.I323M	KRI1_uc002mow.1_Translation_Start_Site|KRI1_uc002mox.1_Missense_Mutation_p.I319M	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	323	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CGGAGGACGCGATGCTGCGTG	0.617													0	0	0	0.00499	0	17	49										C	10670361	G	C	10670361	3	2	39	1	0	0	0	0	1	0	0	0	8444	1048	37	1	1196	1	KRI1	19	10670361	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	6131546	10670361	48458622	233	9636										
NOTCH3	4854	broad.mit.edu	37	chr19	15281188	15281188	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gggttcccgccggcccttgtGaccagaggccacgtccttgt	13	15	0	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:15281188G>A	uc002nan.2	-	27	5144	c.5068C>T	c.(5068-5070)CAC>TAC	p.H1690Y		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1690	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CGGCCCTTGTGACCAGAGGCC	0.657													0	0	0	0.024245	0	15	32										A	15281188	G	A	15281188	3	1	39	1	0	0	0	0	1	0	0	0	10550	1290	45	1	1925	1	NOTCH3	19	15281188	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4610827	15281188	43847795	234	9637										
NWD1	284434	broad.mit.edu	37	chr19	16902160	16902160	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tcctcttcattattctattaGatcaatgcttggaatctgga	6	8	5	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:16902160G>C	uc002neu.3	+	14	3363	c.2941_splice	c.e14-1	p.I981_splice	NWD1_uc002net.3_Splice_Site_p.I846_splice|NWD1_uc002nev.3_Splice_Site_p.I775_splice			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;								ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TATTCTATTAGATCAATGCTT	0.483													0	0	0	0.010818	0	31	69										C	16902160	G	C	16902160	5	2	39	1	0	0	0	0	0	0	1	0	10781	956	33	1	2573	1	NWD1	19	16902160	Splice_Site	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1620972	16902160	42226823	235	9638										
ZNF430	80264	broad.mit.edu	37	chr19	21240308	21240308	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aagataattcatactggagaGaaattctacaaatgtgaaga	8	4	2	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:21240308G>C	uc002npj.2	+	5	1304	c.1194G>C	c.(1192-1194)GAG>GAC	p.E398D	ZNF430_uc002npk.2_Missense_Mutation_p.E397D	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						ATACTGGAGAGAAATTCTACA	0.353													0	0	0	0.006214	0	10	46										C	21240308	G	C	21240308	3	2	39	1	0	0	0	0	1	0	0	0	17901	933	33	1	1212	1	ZNF430	19	21240308	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4338148	21240308	37888675	236	9639										
C19orf40	91442	broad.mit.edu	37	chr19	33467384	33467384	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aagaaccctcttctcgggaaGaaacgggccctgctgctgtc	11	13	2	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:33467384G>A	uc002nud.3	+	5	562	c.444G>A	c.(442-444)AAG>AAA	p.K148K		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	148					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					TTCTCGGGAAGAAACGGGCCC	0.547								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	68										A	33467384	G	A	33467384	2	1	39	1	0	0	0	0	0	0	0	1	1923	933	33	1		1	C19orf40	19	33467384	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	12227076	33467384	25661599	237	9640										
MAP4K1	11184	broad.mit.edu	37	chr19	39104548	39104548	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgtcccaatgaaagagaggcGtctggccagtgtagccccaa	12	11	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:39104548G>A	uc002oix.1	-	8	613	c.505C>T	c.(505-507)CGC>TGC	p.R169C	MAP4K1_uc002oiy.1_Missense_Mutation_p.R169C|MAP4K1_uc010xug.1_Translation_Start_Site	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	169	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AAAGAGAGGCGTCTGGCCAGT	0.627													0	0	0	0.001984	0	7	16										A	39104548	G	A	39104548	3	1	39	1	0	0	0	0	1	0	0	0	9259	1145	40	2	2158	2	MAP4K1	19	39104548	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5637164	39104548	20024435	238	9641										
SUPT5H	6829	broad.mit.edu	37	chr19	39955605	39955605	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	aaggagatgacagacgtgctCaaagtggtgaaggaggtggc	17	5	1	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:39955605C>G	uc002olo.3	+	11	971	c.792C>G	c.(790-792)CTC>CTG	p.L264L	SUPT5H_uc002olp.3_Silent_p.L264L|SUPT5H_uc002olq.3_Silent_p.L260L|SUPT5H_uc002oln.3_Silent_p.L264L|SUPT5H_uc002olr.3_Silent_p.L264L|SUPT5H_uc002ols.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	264	Interaction with SUPT4H1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGACGTGCTCAAAGTGGTGA	0.602													0	0	0	0.010504	0	22	71										G	39955605	C	G	39955605	2	3	39	1	0	0	0	0	0	0	0	1	15396	813	29	1		1	SUPT5H	19	39955605	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	851057	39955605	19173378	239	9642										
PVR	5817	broad.mit.edu	37	chr19	45157217	45157217	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgataacaactggtaccttgGccagaatgaggccaccctga	10	11	0	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:45157217G>A	uc002ozm.2	+	4	1072	c.773G>A	c.(772-774)GGC>GAC	p.G258D	PVR_uc010ejs.2_Missense_Mutation_p.G258D|PVR_uc010xxb.1_Missense_Mutation_p.G258D|PVR_uc010xxc.1_Missense_Mutation_p.G258D|PVR_uc002ozn.2_Missense_Mutation_p.G203D	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	258	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		TGGTACCTTGGCCAGAATGAG	0.493													0	0	0	0.01441	0	88	71										A	45157217	G	A	45157217	3	1	39	1	0	0	0	0	1	0	0	0	12837	1203	42	2	787	2	PVR	19	45157217	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5201612	45157217	13971766	240	9643										
FOSB	2354	broad.mit.edu	37	chr19	45976195	45976195	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tgcccggaggtctccgcgttCgccggcgcccaacgcaccag	13	18	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:45976195C>T	uc002pbx.3	+	4	1534	c.942C>T	c.(940-942)TTC>TTT	p.F314F	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Silent_p.F239F|FOSB_uc002pby.3_Silent_p.F278F|FOSB_uc010eka.1_3'UTR|FOSB_uc010ekb.1_3'UTR|FOSB_uc010ekc.1_3'UTR|FOSB_uc010ekf.2_Silent_p.F275F|FOSB_uc010ekd.1_3'UTR|FOSB_uc010ekg.2_Silent_p.F171F|FOSB_uc002pca.3_Silent_p.F265F	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	314					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		TCTCCGCGTTCGCCGGCGCCC	0.577													0	0	0	0.012319	0	22	66										T	45976195	C	T	45976195	2	4	39	1	0	0	0	0	0	0	0	1	5986	883	31	1		1	FOSB	19	45976195	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	818978	45976195	13152788	241	9644										
SLC8A2	6543	broad.mit.edu	37	chr19	47969393	47969393	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggccgccatgaaacggtcggCgatgatggacactcccagaa	13	12	0	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:47969393C>T	uc002pgx.2	-	2	546	c.268G>A	c.(268-270)GCC>ACC	p.A90T	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Missense_Mutation_p.A90T	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	90	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AAACGGTCGGCGATGATGGAC	0.597													0	0	0	0.010504	0	20	41										T	47969393	C	T	47969393	3	4	39	1	0	0	0	0	1	0	0	0	14707	768	27	2	2533	2	SLC8A2	19	47969393	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	1993198	47969393	11159590	242	9645										
FUZ	80199	broad.mit.edu	37	chr19	50310577	50310577	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccaacaccaggtagcaagctCtgggcagctgggcctggtag	14	12	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:50310577C>G	uc002ppq.1	-	11	1193	c.1088G>C	c.(1087-1089)AGA>ACA	p.R363T	FUZ_uc002ppr.1_Missense_Mutation_p.R263T|FUZ_uc002pps.1_RNA|FUZ_uc002ppt.1_RNA|FUZ_uc002ppu.1_Missense_Mutation_p.R327T|FUZ_uc002ppv.1_Missense_Mutation_p.R313T	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	363	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		GTAGCAAGCTCTGGGCAGCTG	0.607													0	0	0	0.014758	0	5	25										G	50310577	C	G	50310577	3	3	39	1	0	0	0	0	1	0	0	0	6112	913	32	1	172	1	FUZ	19	50310577	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	2341184	50310577	8818406	243	9646										
ETFB	2109	broad.mit.edu	37	chr19	51857428	51857428	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cactgtgcaggcccacagctGacggcgatgacctccttcac	10	16	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:51857428G>A	uc002pwh.2	-	2	284	c.192C>T	c.(190-192)GTC>GTT	p.V64V	ETFB_uc002pwg.2_Silent_p.V155V	NM_001985	NP_001976	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	64					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		GCCCACAGCTGACGGCGATGA	0.428													0	0	0	0.008291	0	11	26										A	51857428	G	A	51857428	2	1	39	1	0	0	0	0	0	0	0	1	5270	1277	45	1		1	ETFB	19	51857428	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1546851	51857428	7271555	244	9647										
SIGLEC8	27181	broad.mit.edu	37	chr19	51957546	51957546	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cgcccgctgctggccttgccGatttcttcctgcaggacctc	10	17	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:51957546G>A	uc002pwt.2	-	6	1239	c.1172C>T	c.(1171-1173)TCG>TTG	p.S391L	SIGLEC8_uc010yda.1_Missense_Mutation_p.S282L|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.S298L	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	391	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGGCCTTGCCGATTTCTTCCT	0.597													0	0	0	0.010504	0	19	68										A	51957546	G	A	51957546	3	1	39	1	0	0	0	0	1	0	0	0	14314	1059	37	1	335	1	SIGLEC8	19	51957546	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	100118	51957546	7171437	245	9648										
ZNF83	55769	broad.mit.edu	37	chr19	53116563	53116563	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tccagtatgaattctccaatGatatgcaaggtatgaatttt	7	6	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:53116563G>A	uc002pzu.3	-	2	2499	c.1255C>T	c.(1255-1257)CAT>TAT	p.H419Y	ZNF83_uc002pzv.3_Missense_Mutation_p.H419Y|ZNF83_uc010eps.2_Missense_Mutation_p.H391Y|ZNF83_uc010ept.2_Missense_Mutation_p.H419Y|ZNF83_uc010epu.2_Missense_Mutation_p.H419Y|ZNF83_uc010epv.2_Missense_Mutation_p.H419Y|ZNF83_uc010epw.2_Missense_Mutation_p.H419Y|ZNF83_uc010epx.2_Missense_Mutation_p.H391Y|ZNF83_uc010epy.2_Missense_Mutation_p.H419Y|ZNF83_uc010epz.2_Missense_Mutation_p.H391Y	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	419	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		ATTCTCCAATGATATGCAAGG	0.373													0	0	0	0.00632	0	28	100										A	53116563	G	A	53116563	3	1	39	1	0	0	0	0	1	0	0	0	18180	1290	45	1	299	1	ZNF83	19	53116563	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	1159017	53116563	6012420	246	9649										
ZNF665	79788	broad.mit.edu	37	chr19	53678789	53678789	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	catgtccactcctcctgagaGaattctatggccacatcctt	6	14	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:53678789G>A	uc010eqm.1	-	3	151	c.51C>T	c.(49-51)TTC>TTT	p.F17F		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	Error:Variant_position_missing_in_Q9H7R5_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		CCTCCTGAGAGAATTCTATGG	0.438													0	0	0	0.027356	0	26	100										A	53678789	G	A	53678789	2	1	39	1	0	0	0	0	0	0	0	1	18070	933	33	1		1	ZNF665	19	53678789	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	562226	53678789	5450194	247	9650										
TMC4	147798	broad.mit.edu	37	chr19	54666454	54666454	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctgccaagacagtcagcagaTcaaagagcagaagtttgtac	10	9	2	4			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:54666454T>A	uc010erf.2	-	10	1604	c.1472A>T	c.(1471-1473)GAT>GTT	p.D491V	TMC4_uc002qdn.2_Missense_Mutation_p.D205V|TMC4_uc002qdo.2_Missense_Mutation_p.D485V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	491	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGTCAGCAGATCAAAGAGCAG	0.567													0	0	0	0.010729	0	11	9										A	54666454	T	A	54666454	3	1	39	1	0	0	0	0	1	0	0	0	15984	1435	50	5	690	5	TMC4	19	54666454	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	987665	54666454	4462529	248	9651										
USP29	57663	broad.mit.edu	37	chr19	57642078	57642078	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gcccagacacaaggcttgtcGaggttcatcttcaagaggtg	12	10	3	2	rs143453181		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:57642078G>A	uc002qny.2	+	4	2391	c.2035G>A	c.(2035-2037)GAG>AAG	p.E679K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	679					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGGCTTGTCGAGGTTCATCT	0.468													0	0	0	0.006214	0	9	50										A	57642078	G	A	57642078	3	1	39	1	0	0	0	0	1	0	0	0	17056	1059	37	1	2037	1	USP29	19	57642078	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	2975624	57642078	1486905	249	9652										
ZSCAN1	284312	broad.mit.edu	37	chr19	58549427	58549427	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggcccgaggcgcgctccaagGagcagatgctggagctgctg	17	12	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:58549427G>T	uc002qrc.1	+	3	470	c.223G>T	c.(223-225)GAG>TAG	p.E75*	ZSCAN1_uc002qra.1_Nonsense_Mutation_p.E75*|ZSCAN1_uc002qrb.1_Nonsense_Mutation_p.E75*	NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCGCTCCAAGGAGCAGATGCT	0.706													1	0	0.00116845	0.021553	0.00119008	5	19										T	58549427	G	T	58549427	4	4	39	1	0	0	0	0	0	1	0	0	18223	1175	41	3	225	3	ZSCAN1	19	58549427	Nonsense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	907349	58549427	579556	250	9653										
ZBTB45	84878	broad.mit.edu	37	chr19	59028629	59028629	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gagtggcgggggcacaggggTgggcaggggcgtgggcgcag	26	7	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:59028629T>G	uc002qtd.2	-	2	704	c.412A>C	c.(412-414)ACC>CCC	p.T138P	ZBTB45_uc002qte.2_Missense_Mutation_p.T138P|ZBTB45_uc002qtf.2_Missense_Mutation_p.T138P	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	138	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GGCACAGGGGTGGGCAGGGGC	0.716											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	6	3										G	59028629	T	G	59028629	3	3	39	1	0	0	0	0	1	0	0	0	17543	1696	59	5	1131	5	ZBTB45	19	59028629	Missense_Mutation	SNP	T	TCGA-CU-A3YL-01A-11D-A22Z-08	479202	59028629	100354	251	9654										
TRIM28	10155	broad.mit.edu	37	chr19	59057194	59057194	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtgtggagtgctcggagcctCtgtgtgagacctgtgtagag	17	7	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:59057194C>T	uc002qtg.1	+	3	806	c.517C>T	c.(517-519)CTG>TTG	p.L173L	TRIM28_uc010eut.1_Intron|TRIM28_uc002qth.1_5'Flank	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	173	RBCC domain.|B box-type 1; atypical.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CTCGGAGCCTCTGTGTGAGAC	0.572													0	0	0	0.016723	0	13	36										T	59057194	C	T	59057194	2	4	39	1	0	0	0	0	0	0	0	1	16499	912	32	1		1	TRIM28	19	59057194	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	28565	59057194	71789	252	9655										
PANK2	80025	broad.mit.edu	37	chr20	3888748	3888748	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggcattcgggacgtgcacctCgagctgaaggacctgactct	13	12	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:3888748C>T	uc002wkc.2	+	2	810	c.804C>T	c.(802-804)CTC>CTT	p.L268L	PANK2_uc002wkb.2_5'UTR|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'UTR|PANK2_uc002wkf.2_5'UTR	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	268					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						ACGTGCACCTCGAGCTGAAGG	0.478													0	0	0	0.016723	0	14	59										T	3888748	C	T	3888748	2	4	39	1	0	0	0	0	0	0	0	1	11417	871	31	1		1	PANK2	20	3888748	Silent	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		3888748	59136772	253	9656										
C20orf94	128710	broad.mit.edu	37	chr20	10603663	10603663	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	atgtccaaaacaaagtccacGagtggccaaaacccaacaga	7	12	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:10603663G>A	uc010zre.1	+	8	1043	c.863G>A	c.(862-864)CGA>CAA	p.R288Q		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	288							protein binding				0						CAAAGTCCACGAGTGGCCAAA	0.527													0	0	0	0.016522	0	22	46										A	10603663	G	A	10603663	3	1	39	1	0	0	0	0	1	0	0	0	2121	1058	37	1	889	1	C20orf94	20	10603663	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	6714915	10603663	52421857	254	9657										
TTC3	7267	broad.mit.edu	37	chr21	38510991	38510991	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tctatggacttgccatttctCtccttggaataggacagcct	8	11	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:38510991C>G	uc002yvz.2	+	19	1741	c.1636C>G	c.(1636-1638)CTC>GTC	p.L546V	TTC3_uc011aee.1_Missense_Mutation_p.L236V|TTC3_uc002ywa.2_Missense_Mutation_p.L546V|TTC3_uc002ywb.2_Missense_Mutation_p.L546V|TTC3_uc010gnf.2_Missense_Mutation_p.L311V|TTC3_uc002ywc.2_Missense_Mutation_p.L236V|TTC3_uc011aed.1_Missense_Mutation_p.L236V|TTC3_uc010gne.1_Missense_Mutation_p.L546V	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	546	TPR 3.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TGCCATTTCTCTCCTTGGAAT	0.308													0	0	0	0.012213	0	31	64										G	38510991	C	G	38510991	3	3	39	1	0	0	0	0	1	0	0	0	16694	913	32	1	1706	1	TTC3	21	38510991	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		38510991	9618904	255	9658										
UMODL1	89766	broad.mit.edu	37	chr21	43541202	43541202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctaaatgttgtgcagattacGatgagtgtgaaaggaaggag	14	3	0	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:43541202G>A	uc002zaf.1	+	16	2695	c.2695G>A	c.(2695-2697)GAT>AAT	p.D899N	UMODL1_uc002zad.1_Missense_Mutation_p.D827N|UMODL1_uc002zae.1_Missense_Mutation_p.D955N|UMODL1_uc002zag.1_Missense_Mutation_p.D1027N|UMODL1_uc002zal.1_5'UTR	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	899	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TGCAGATTACGATGAGTGTGA	0.537													0	0	0	0.010504	0	21	61										A	43541202	G	A	43541202	3	1	39	1	0	0	0	0	1	0	0	0	16977	1058	37	1	3137	1	UMODL1	21	43541202	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	5030211	43541202	4588693	256	9659										
COL18A1	80781	broad.mit.edu	37	chr21	46888254	46888254	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ccgacgtcgggctggcctacGtctttgggccagatgccaac	13	14	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:46888254G>A	uc011afs.1	+	2	1471	c.1450G>A	c.(1450-1452)GTC>ATC	p.V484I	COL18A1_uc002zhg.2_Missense_Mutation_p.V69I|COL18A1_uc002zhi.2_Missense_Mutation_p.V249I	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	484	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCTGGCCTACGTCTTTGGGCC	0.657													0	0	0	0.013726	0	32	53										A	46888254	G	A	46888254	3	1	39	1	0	0	0	0	1	0	0	0	3675	1145	40	2	1570	2	COL18A1	21	46888254	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	3347052	46888254	1241641	257	9660										
ARVCF	421	broad.mit.edu	37	chr22	19960296	19960296	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagtggcagcgtgctgtcatCgaagcccccaggactcagtg	13	13	2	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:19960296C>T	uc002zqz.2	-	16	2876	c.2605G>A	c.(2605-2607)GAT>AAT	p.D869N	ARVCF_uc002zqy.2_Missense_Mutation_p.D385N	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	869					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					GTGCTGTCATCGAAGCCCCCA	0.602													0	0	0	0.004482	0	9	26										T	19960296	C	T	19960296	3	4	39	1	0	0	0	0	1	0	0	0	1003	884	31	1	299	1	ARVCF	22	19960296	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08		19960296	31344270	258	9661										
TRMT2A	27037	broad.mit.edu	37	chr22	20100722	20100722	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	cagggtgggcaccaggtcctCggccctcccgcagtggaact	14	15	0	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:20100722C>T	uc002zrk.1	-	11	1683	c.1468G>A	c.(1468-1470)GAG>AAG	p.E490K	TRMT2A_uc002zrl.1_Missense_Mutation_p.E490K|TRMT2A_uc002zrm.1_Missense_Mutation_p.E312K|TRMT2A_uc002zrn.1_Missense_Mutation_p.E508K	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	490					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						ACCAGGTCCTCGGCCCTCCCG	0.647													0	0	0	0.007413	0	19	21										T	20100722	C	T	20100722	3	4	39	1	0	0	0	0	1	0	0	0	16562	893	31	1	421	1	TRMT2A	22	20100722	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	140426	20100722	31203844	259	9662										
RTDR1	27156	broad.mit.edu	37	chr22	23406202	23406202	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gtggcatcctcctgcaggcaGaggaccagtgtgtccaggat	14	11	0	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:23406202G>T	uc002zwt.2	-	5	689	c.531C>A	c.(529-531)CTC>CTA	p.L177L		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	177							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		CCTGCAGGCAGAGGACCAGTG	0.582													1	0	2.0095e-06	0.001984	2.09191e-06	7	16										T	23406202	G	T	23406202	2	4	39	1	0	0	0	0	0	0	0	1	13719	929	33	3		3	RTDR1	22	23406202	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	3305480	23406202	27898364	260	9663										
DNAL4	10126	broad.mit.edu	37	chr22	39178724	39178724	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	agcctcatctttcttcccttCtgtttctcccatgatccttc	3	16	5	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:39178724C>G	uc003awj.2	-	2	241	c.13G>C	c.(13-15)GAA>CAA	p.E5Q	SUN2_uc010gxr.1_Intron	NM_005740	NP_005731	O96015	DNAL4_HUMAN	dynein light chain 4, axonemal	5					microtubule-based movement|nerve growth factor receptor signaling pathway	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|plasma membrane	ATPase activity, coupled|microtubule motor activity				0	Melanoma(58;0.04)					TTCTTCCCTTCTGTTTCTCCC	0.572													0	0	0	0.006214	0	10	30										G	39178724	C	G	39178724	3	3	39	1	0	0	0	0	1	0	0	0	4658	922	32	1	316	1	DNAL4	22	39178724	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	15772522	39178724	12125842	261	9664										
FAM118A	55007	broad.mit.edu	37	chr22	45728377	45728377	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggggagacccttcgtgatcaGatattccaggccctctttct	10	12	3	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:45728377G>T	uc003bfz.3	+	7	1339	c.723G>T	c.(721-723)CAG>CAT	p.Q241H	FAM118A_uc003bga.3_Missense_Mutation_p.Q241H|FAM118A_uc011aqr.1_Missense_Mutation_p.Q59H	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	241						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TTCGTGATCAGATATTCCAGG	0.463													1	0	3.78316e-11	0.025465	4.04027e-11	42	67										T	45728377	G	T	45728377	3	4	39	1	0	0	0	0	1	0	0	0	5411	933	33	3	741	3	FAM118A	22	45728377	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	6549653	45728377	5576189	262	9665										
BRD1	23774	broad.mit.edu	37	chr22	50187866	50187866	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ttcatagcgcaggtgaggtcGagcatgtccagcagctctct	12	11	2	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:50187866G>A	uc003biv.2	-	6	2662	c.2175C>T	c.(2173-2175)CTC>CTT	p.L725L	BRD1_uc011arf.1_Silent_p.L320L|BRD1_uc011arg.1_Silent_p.L774L|BRD1_uc011arh.1_Silent_p.L725L|BRD1_uc003biu.3_Silent_p.L725L	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	725					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGTGAGGTCGAGCATGTCCA	0.597													0	0	0	0.006122	0	17	32										A	50187866	G	A	50187866	2	1	39	1	0	0	0	0	0	0	0	1	1501	1045	37	1		1	BRD1	22	50187866	Silent	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	4459489	50187866	1116700	263	9666										
PLXNB2	23654	broad.mit.edu	37	chr22	50727555	50727555	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggtgctccgagccacatgggAagctcttgctggagccctgc	14	13	1	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:50727555A>G	uc003bkv.3	-	4	1191	c.1085T>C	c.(1084-1086)TTC>TCC	p.F362S		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	362	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCACATGGGAAGCTCTTGCT	0.687													0	0	0	0.004672	0	3	10										G	50727555	A	G	50727555	3	3	39	1	0	0	0	0	1	0	0	0	12124	246	9	5	4567	5	PLXNB2	22	50727555	Missense_Mutation	SNP	A	TCGA-CU-A3YL-01A-11D-A22Z-08	539689	50727555	577011	264	9667										
MXRA5	25878	broad.mit.edu	37	chrX	3238723	3238723	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggagaggaattgttgtacttGataatcttggagttgtaaac	12	3	1	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:3238723G>C	uc004crg.3	-	5	5160	c.5003C>G	c.(5002-5004)TCA>TGA	p.S1668*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1668						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTTGTACTTGATAATCTTGG	0.438													0	0	0	0.01441	0	150	35										C	3238723	G	C	3238723	4	2	39	1	0	0	0	0	0	1	0	0	10003	1294	45	1	3495	1	MXRA5	23	3238723	Nonsense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08		3238723	152031837	265	9668										
UBA1	7317	broad.mit.edu	37	chrX	47062396	47062396	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ggctatactttgatgcccttGagtgtctccctgaggacaaa	10	10	1	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:47062396G>A	uc004dhj.3	+	12	1439	c.1288G>A	c.(1288-1290)GAG>AAG	p.E430K	UBA1_uc004dhk.3_Missense_Mutation_p.E430K|INE1_uc004dhl.2_5'Flank	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	430	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						TGATGCCCTTGAGTGTCTCCC	0.582													0	0	0	0.027894	0	39	5										A	47062396	G	A	47062396	3	1	39	1	0	0	0	0	1	0	0	0	16824	1291	45	1	1330	1	UBA1	23	47062396	Missense_Mutation	SNP	G	TCGA-CU-A3YL-01A-11D-A22Z-08	43823673	47062396	108208164	266	9669										
KCND1	3750	broad.mit.edu	37	chrX	48825780	48825780	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	tggagaacttgaagatgcgaAacacccggaacacacgcagg	12	10	0	3			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:48825780A>G	uc004dlx.1	-	1	2472	c.899T>C	c.(898-900)TTT>TCT	p.F300S	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	300	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						GAAGATGCGAAACACCCGGAA	0.552													0	0	0	0.008291	0	10	15										G	48825780	A	G	48825780	3	3	39	1	0	0	0	0	1	0	0	0	8018	14	1	5	1068	5	KCND1	23	48825780	Missense_Mutation	SNP	A	TCGA-CU-A3YL-01A-11D-A22Z-08	1763384	48825780	106444780	267	9670										
TRO	7216	broad.mit.edu	37	chrX	54955643	54955643	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	ctttagtggtggagtcagctCtagttttagtggcccactca	11	9	3	0			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:54955643C>G	uc004dtq.2	+	12	2593	c.2486C>G	c.(2485-2487)TCT>TGT	p.S829C	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.S360C|TRO_uc004dtw.2_Missense_Mutation_p.S432C|TRO_uc004dtx.2_Missense_Mutation_p.S212C	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	829	6; approximate.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GGAGTCAGCTCTAGTTTTAGT	0.547													0	0	0	0.023175	0	41	6										G	54955643	C	G	54955643	3	3	39	1	0	0	0	0	1	0	0	0	16571	913	32	1	2528	1	TRO	23	54955643	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	6129863	54955643	100314917	268	9671										
RPS4X	6191	broad.mit.edu	37	chrX	71493144	71493144	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gttgccattggcatctttcaCgtgaaccacgtcaaaagatc	8	11	3	2			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:71493144C>T	uc004ear.2	-	6	724	c.628G>A	c.(628-630)GTG>ATG	p.V210M		NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	210					endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					GCATCTTTCACGTGAACCACG	0.463													0	0	0	0.015359	0	34	3										T	71493144	C	T	71493144	3	4	39	1	0	0	0	0	1	0	0	0	13645	536	19	2	171	2	RPS4X	23	71493144	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	16537501	71493144	83777416	269	9672										
KIAA1210	57481	broad.mit.edu	37	chrX	118228014	118228014	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.533333333333333	144	3.86622035184946e-54	3.95637247455567	4.69366038630169	3.40624226348364	0.908025148009144	0.967567780665481	108	gacacactgcagggatccctCtaaaataccctggaaatgac	8	12	1	1			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:118228014C>G	uc004era.3	-	9	1312	c.1312G>C	c.(1312-1314)GAG>CAG	p.E438Q		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	438										ovary(4)|skin(1)	5						AGGGATCCCTCTAAAATACCC	0.483													0	0	0	0.008361	0	32	5										G	118228014	C	G	118228014	3	3	39	1	0	0	0	0	1	0	0	0	8214	922	32	1	3841	1	KIAA1210	23	118228014	Missense_Mutation	SNP	C	TCGA-CU-A3YL-01A-11D-A22Z-08	46734870	118228014	37042546	270	9673										
PRDM16	63976	broad.mit.edu	37	chr1	3319489	3319489	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggctgaggagctcaagcccGagggccttggcggtggcagc	18	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:3319489G>C	uc001akf.2	+	6	891	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	PRDM16_uc001akc.2_Missense_Mutation_p.E271Q|PRDM16_uc001akd.2_Missense_Mutation_p.E271Q|PRDM16_uc001ake.2_Missense_Mutation_p.E271Q|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	271					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCTCAAGCCCGAGGGCCTTGG	0.622			T	EVI1	MDS|AML								0	0	0	0.007413	0	15	55										C	3319489	G	C	3319489	3	2	40	1	0	0	0	0	1	0	0	0	12457	1059	37	1	833	1	PRDM16	1	3319489	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		3319489	245931132	1	9674										
CHD5	26038	broad.mit.edu	37	chr1	6173059	6173059	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttctcaggaagcacctcctCtgcaagaaaaagagggttcg	10	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6173059C>G	uc001amb.1	-	34	5013	c.4913_splice	c.e34-1	p.E1638_splice	CHD5_uc001alz.1_Splice_Site_p.E495_splice|CHD5_uc001ama.1_Splice_Site	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGCACCTCCTCTGCAAGAAAA	0.562													0	0	0	0.00245	0	15	66										G	6173059	C	G	6173059	5	3	40	1	0	0	0	0	0	0	1	0	3328	927	32	1	984	1	CHD5	1	6173059	Splice_Site	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2853570	6173059	243077562	2	9675										
TNFRSF25	8718	broad.mit.edu	37	chr1	6525566	6525567	+	Frame_Shift_Ins	INS	-	-	G													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaccggcacagtcacacctINSggggctacgagtgccgccct							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6525566_6525567insG	uc001ane.2	-	2	181_182	c.93_94insC	c.(91-96)CCCAGGfs	p.P31fs	TNFRSF25_uc001ana.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_5'UTR|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001ang.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001anh.2_Frame_Shift_Ins_p.P31fs|TNFRSF25_uc001ani.1_Frame_Shift_Ins_p.P31fs	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	31_32	Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CAGTCACACCTGGGGCTACGAG	0.673																		9	43	---	---								G	6525567	-	G	6525566	7	5	40	1	0	1	1	0	0	0	0	0	16293	1579	55	0	1226	0	TNFRSF25	1	6525566	Frame_Shift_Ins	INS	-	TCGA-DK-A1A3-01A-11D-A13W-08	352507	6525566	242725055	3	9676										
ZBTB48	3104	broad.mit.edu	37	chr1	6649195	6649195	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccagagactgtgtgcagagGagagcttcaccggcccaggt	15	11	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6649195G>A	uc009vmc.1	+	11	2113	c.1990G>A	c.(1990-1992)GAG>AAG	p.E664K	ZBTB48_uc001anx.2_Missense_Mutation_p.E664K|ZBTB48_uc009vmd.1_Missense_Mutation_p.E664K|ZBTB48_uc001any.1_Missense_Mutation_p.E302K	NM_005341	NP_005332	P10074	ZBT48_HUMAN	zinc finger and BTB domain containing 48	664						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.35e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00109)|STAD - Stomach adenocarcinoma(132;0.017)|READ - Rectum adenocarcinoma(331;0.0642)		GTGTGCAGAGGAGAGCTTCAC	0.667													0	0	0	0.00245	0	15	71										A	6649195	G	A	6649195	3	1	40	1	0	0	0	0	1	0	0	0	17546	1175	41	1	2028	1	ZBTB48	1	6649195	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	123629	6649195	242601426	4	9677										
CAMTA1	23261	broad.mit.edu	37	chr1	6885189	6885189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatagtagtcatgtaaaaatCtttttaccgaaaaagctgct	6	6	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:6885189C>G	uc001aoi.2	+	3	360	c.153C>G	c.(151-153)ATC>ATG	p.I51M	CAMTA1_uc001aoh.2_RNA	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ATGTAAAAATCTTTTTACCGA	0.323													0	0	0	0.005443	0	27	97										G	6885189	C	G	6885189	3	3	40	1	0	0	0	0	1	0	0	0	2613	903	32	1	163	1	CAMTA1	1	6885189	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	235994	6885189	242365432	5	9678										
UTS2	10911	broad.mit.edu	37	chr1	7907829	7907829	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagatgcttatttcacttcaGacacagtatttccagaagca	6	10	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:7907829G>C	uc001aor.2	-	4	413	c.372C>G	c.(370-372)GTC>GTG	p.V124V	UTS2_uc001aoq.2_Intron|UTS2_uc001aos.2_Silent_p.V139V	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein	124					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		TTTCACTTCAGACACAGTATT	0.373													0	0	0	0.01441	0	47	266										C	7907829	G	C	7907829	2	2	40	1	0	0	0	0	0	0	0	1	17101	929	33	1		1	UTS2	1	7907829	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1022640	7907829	241342792	6	9679										
ENO1	2023	broad.mit.edu	37	chr1	8927225	8927226	+	Frame_Shift_Ins	INS	-	-	GG													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agccaagtcagcgatgtggcINSggtacagggggacccccttc					rs144538182	by1000genomes	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:8927225_8927226insGG	uc001apj.1	-	6	545_546	c.394_395insCC	c.(394-396)CGCfs	p.R132fs	ENO1_uc001api.1_Frame_Shift_Ins_p.R36fs|ENO1_uc001apk.1_Frame_Shift_Ins_p.R77fs|ENO1_uc001apl.1_Frame_Shift_Ins_p.R132fs|ENO1_uc009vmi.1_Frame_Shift_Ins_p.R89fs|ENO1_uc009vmj.1_Frame_Shift_Ins_p.R132fs|ENO1_uc009vmk.1_Intron|ENO1_uc009vml.1_Frame_Shift_Ins_p.R132fs	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	132	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		AGCGATGTGGCGGTACAGGGGG	0.559																		9	81	---	---								GG	8927226	-	GG	8927225	7	5	40	1	0	1	1	0	0	0	0	0	5121	768	27	0	937	0	ENO1	1	8927225	Frame_Shift_Ins	INS	-	TCGA-DK-A1A3-01A-11D-A13W-08	1019396	8927225	240323396	7	9680										
SRM	6723	broad.mit.edu	37	chr1	11115915	11115915	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcagtaggcataggccaccaCggggaacagggactggcaga	16	10	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:11115915C>T	uc001arz.1	-	6	779	c.688G>A	c.(688-690)GTG>ATG	p.V230M	SRM_uc001ary.1_Missense_Mutation_p.V91M	NM_003132	NP_003123	P19623	SPEE_HUMAN	spermidine synthase	230					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity				0	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	TAGGCCACCACGGGGAACAGG	0.642													0	0	0	0.000602	0	3	24										T	11115915	C	T	11115915	3	4	40	1	0	0	0	0	1	0	0	0	15150	536	19	2	232	2	SRM	1	11115915	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2188690	11115915	238134706	8	9681										
CROCC	9696	broad.mit.edu	37	chr1	17249254	17249254	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcctgcctgcccttatcaggGagattgtcacccgcaacctc	9	16	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:17249254G>A	uc001azt.2	+	2	226	c.157G>A	c.(157-159)GAG>AAG	p.E53K	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	53					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCTTATCAGGGAGATTGTCAC	0.622													0	0	0	0.003755	0	35	109										A	17249254	G	A	17249254	3	1	40	1	0	0	0	0	1	0	0	0	3893	1175	41	1	163	1	CROCC	1	17249254	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6133339	17249254	232001367	9	9682										
UBR4	23352	broad.mit.edu	37	chr1	19487565	19487565	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacgcactagactctctgaaAtcctgggttcactctgaaat	8	11	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:19487565A>G	uc001bbi.2	-	38	5256	c.5252T>C	c.(5251-5253)ATT>ACT	p.I1751T	UBR4_uc001bbm.1_Missense_Mutation_p.I962T	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1751					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ACTCTCTGAAATCCTGGGTTC	0.517													0	0	0	0.001168	0	6	92										G	19487565	A	G	19487565	3	3	40	1	0	0	0	0	1	0	0	0	16901	101	4	5	10575	5	UBR4	1	19487565	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	2238311	19487565	229763056	10	9683										
AKR7L	246181	broad.mit.edu	37	chr1	19595155	19595155	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgcggcctgcagggccttctCcaccagggcaatgccctcga	12	17	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:19595155C>A	uc010ocx.1	-	7	745	c.745G>T	c.(745-747)GAG>TAG	p.E249*	AKR7L_uc010ocy.1_Missense_Mutation_p.G183V	NM_201252	NP_957704			aflatoxin B1 aldehyde reductase 3 isoform 1												0						AGGGCCTTCTCCACCAGGGCA	0.632													1	0	2.32078e-09	0.003163	2.39697e-09	14	86										A	19595155	C	A	19595155	4	1	40	1	0	0	0	0	0	1	0	0	477	864	30	3	258	3	AKR7L	1	19595155	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	107590	19595155	229655466	11	9684										
RNF186	54546	broad.mit.edu	37	chr1	20141360	20141360	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcacagcgggcaggtgatggAccaggtgttgtcctgcacgc	16	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:20141360A>T	uc001bcr.2	-	1	412	c.235T>A	c.(235-237)TCC>ACC	p.S79T		NM_019062	NP_061935	Q9NXI6	RN186_HUMAN	ring finger protein 186	79	RING-type.					integral to membrane	zinc ion binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;7.77e-05)|Kidney(64;0.000162)|GBM - Glioblastoma multiforme(114;0.00036)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGTGATGGACCAGGTGTTG	0.692													0	0	0	0.007835	0	38	26										T	20141360	A	T	20141360	3	4	40	1	0	0	0	0	1	0	0	0	13469	275	10	5	452	5	RNF186	1	20141360	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	546205	20141360	229109261	12	9685										
EPHA8	2046	broad.mit.edu	37	chr1	22924702	22924702	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggctctctggacaccttcctGagggtgcgtgtcccacccct	11	16	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:22924702G>C	uc001bfx.1	+	12	2300	c.2175G>C	c.(2173-2175)CTG>CTC	p.L725L		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	725	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACACCTTCCTGAGGGTGCGTG	0.627													0	0	0	0.005443	0	23	121										C	22924702	G	C	22924702	2	2	40	1	0	0	0	0	0	0	0	1	5173	1277	45	1		1	EPHA8	1	22924702	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2783342	22924702	226325919	13	9686										
TCEA3	6920	broad.mit.edu	37	chr1	23713897	23713897	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attcctcaactccctcagttCatcactggccatttcctgga	5	15	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:23713897C>T	uc001bgx.1	-	9	970	c.835G>A	c.(835-837)GAA>AAA	p.E279K	TCEA3_uc009vqm.1_Missense_Mutation_p.E48K	NM_003196	NP_003187	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	279	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		TCCCTCAGTTCATCACTGGCC	0.557													0	0	0	0.00499	0	17	11										T	23713897	C	T	23713897	3	4	40	1	0	0	0	0	1	0	0	0	15666	835	29	1	223	1	TCEA3	1	23713897	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	789195	23713897	225536724	14	9687										
E2F2	1870	broad.mit.edu	37	chr1	23848342	23848342	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cactcacacccactggatgtTgttcttggccttcttgcgga	9	13	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:23848342T>C	uc001bhe.1	-	3	993	c.565A>G	c.(565-567)AAC>GAC	p.N189D		NM_004091	NP_004082	Q14209	E2F2_HUMAN	E2F transcription factor 2	189	DEF box.|Potential.				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|skin(2)	4		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		CACTGGATGTTGTTCTTGGCC	0.602													0	0	0	0.010729	0	11	89										C	23848342	T	C	23848342	3	2	40	1	0	0	0	0	1	0	0	0	4867	1812	63	5	768	5	E2F2	1	23848342	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	134445	23848342	225402279	15	9688										
GRHL3	57822	broad.mit.edu	37	chr1	24661179	24661179	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcctccagcactgggggcagGaatgaccaaggaaagaggtg	15	9	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:24661179G>A	uc001biy.2	+	3	310	c.264G>A	c.(262-264)AGG>AGA	p.R88R	GRHL3_uc001bix.2_Silent_p.R83R|GRHL3_uc001biz.2_5'UTR	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	83					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CTGGGGGCAGGAATGACCAAG	0.507													0	0	0	0.008871	0	19	211										A	24661179	G	A	24661179	2	1	40	1	0	0	0	0	0	0	0	1	6765	1165	41	1		1	GRHL3	1	24661179	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	812837	24661179	224589442	16	9689										
GPN2	54707	broad.mit.edu	37	chr1	27216404	27216404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtcgcccagccccaccagctCgcccacgtccacggcacact	8	22	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:27216404C>T	uc001bnd.1	-	1	466	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	62							GTP binding				0						CCCACCAGCTCGCCCACGTCC	0.701													0	0	0	0.004878	0	34	10										T	27216404	C	T	27216404	3	4	40	1	0	0	0	0	1	0	0	0	6618	893	31	1	768	1	GPN2	1	27216404	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2555225	27216404	222034217	17	9690										
SYTL1	84958	broad.mit.edu	37	chr1	27675622	27675622	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taaaggcttcagatcctgagGaggcgtcccaggcccaggaa	13	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:27675622G>A	uc001bnw.1	+	6	678	c.511G>A	c.(511-513)GAG>AAG	p.E171K	SYTL1_uc001bnv.1_Missense_Mutation_p.E159K|SYTL1_uc009vsu.1_Missense_Mutation_p.E159K|SYTL1_uc001bnx.2_Missense_Mutation_p.E171K|SYTL1_uc009vsv.1_Missense_Mutation_p.E171K	NM_032872	NP_116261	Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	171					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			ovary(1)	1		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGATCCTGAGGAGGCGTCCCA	0.617													0	0	0	0.007413	0	20	53										A	27675622	G	A	27675622	3	1	40	1	0	0	0	0	1	0	0	0	15479	1175	41	1	493	1	SYTL1	1	27675622	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	459218	27675622	221574999	18	9691										
FCN3	8547	broad.mit.edu	37	chr1	27695779	27695779	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggtggcccacaccacggcctGaggcccagtcaatgccatat	11	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:27695779G>C	uc001boa.2	-	8	854	c.848C>G	c.(847-849)TCA>TGA	p.S283*	MAP3K6_uc001bny.1_5'Flank|MAP3K6_uc009vsw.1_5'Flank|FCN3_uc001bob.2_Nonsense_Mutation_p.S272*	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	283	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCACGGCCTGAGGCCCAGTC	0.577													0	0	0	0.010729	0	10	65										C	27695779	G	C	27695779	4	2	40	1	0	0	0	0	0	1	0	0	5793	1294	45	1	55	1	FCN3	1	27695779	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	20157	27695779	221554842	19	9692										
SDC3	9672	broad.mit.edu	37	chr1	31346158	31346158	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctcatcctttttcttcataCgatagatgagcagtgtgacc	7	11	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:31346158C>T	uc001bse.2	-	5	1276	c.1229G>A	c.(1228-1230)CGT>CAT	p.R410H	SDC3_uc001bsd.2_Missense_Mutation_p.R352H	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	410	Cytoplasmic (Potential).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCTTCATACGATAGATGAG	0.562													0	0	0	0.00245	0	13	66										T	31346158	C	T	31346158	3	4	40	1	0	0	0	0	1	0	0	0	13953	536	19	2	103	2	SDC3	1	31346158	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3650379	31346158	217904463	20	9693										
RBBP4	5928	broad.mit.edu	37	chr1	33138430	33138430	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	actgccaagatatctgatttCtcctggaatcccaatgaacc	6	12	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:33138430C>T	uc001bvr.2	+	11	1299	c.1140C>T	c.(1138-1140)TTC>TTT	p.F380F	RBBP4_uc001bvs.2_Silent_p.F379F|RBBP4_uc010ohj.1_Silent_p.F128F|RBBP4_uc010ohk.1_Silent_p.F345F	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	380	WD 6.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				TATCTGATTTCTCCTGGAATC	0.373													0	0	0	0.00499	0	16	96										T	33138430	C	T	33138430	2	4	40	1	0	0	0	0	0	0	0	1	13101	912	32	1		1	RBBP4	1	33138430	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1792272	33138430	216112191	21	9694										
C1orf216	127703	broad.mit.edu	37	chr1	36181308	36181308	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctccttccggttgtctagGatggtgtcgaagctctcctg	12	11	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:36181308G>A	uc001bzh.1	-	2	1103	c.615C>T	c.(613-615)ATC>ATT	p.I205I		NM_152374	NP_689587	Q8TAB5	CA216_HUMAN	hypothetical protein LOC127703	205										skin(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGTTGTCTAGGATGGTGTCGA	0.607											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	22	108										A	36181308	G	A	36181308	2	1	40	1	0	0	0	0	0	0	0	1	2031	1164	41	1		1	C1orf216	1	36181308	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3042878	36181308	213069313	22	9695										
GRIK3	2899	broad.mit.edu	37	chr1	37499707	37499707	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggcgccgccagggagcggtCatcgttgggcgccgccgagc	18	14	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:37499707C>T	uc001caz.2	-	1	138	c.3G>A	c.(1-3)ATG>ATA	p.M1I	GRIK3_uc001cba.1_Missense_Mutation_p.M1I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	1					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	AGGGAGCGGTCATCGTTGGGC	0.771													0	0	0	0.004672	0	3	3										T	37499707	C	T	37499707	3	4	40	1	0	0	0	0	1	0	0	0	6775	826	29	1	2820	1	GRIK3	1	37499707	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1318399	37499707	211750914	23	9696										
ZC3H12A	80149	broad.mit.edu	37	chr1	37947425	37947425	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggctgctcatgtactccttCgtcaatgacaagtatgttcc	8	12	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:37947425C>T	uc001cbb.3	+	4	957	c.807C>T	c.(805-807)TTC>TTT	p.F269F	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	269					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGTACTCCTTCGTCAATGACA	0.612													0	0	0	0.001855	0	13	21										T	37947425	C	T	37947425	2	4	40	1	0	0	0	0	0	0	0	1	17558	883	31	1		1	ZC3H12A	1	37947425	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	447718	37947425	211303196	24	9697										
EPHA10	284656	broad.mit.edu	37	chr1	38197174	38197174	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcccggatctgaaagacgtaGcgggtagccggcttcaggtt	15	10	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:38197174G>A	uc009vvi.2	-	7	1658	c.1572C>T	c.(1570-1572)CGC>CGT	p.R524R	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	524	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAAAGACGTAGCGGGTAGCCG	0.587													0	0	0	0.01441	0	40	72										A	38197174	G	A	38197174	2	1	40	1	0	0	0	0	0	0	0	1	5166	958	34	2		2	EPHA10	1	38197174	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	249749	38197174	211053447	25	9698										
MACF1	23499	broad.mit.edu	37	chr1	39797480	39797480	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcaggggggatggtgagcttGaaatcaggccggaaggttag	19	5	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39797480G>C	uc010oiu.1	+	1	671	c.540G>C	c.(538-540)TTG>TTC	p.L180F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1745					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGTGAGCTTGAAATCAGGCC	0.488													0	0	0	0.006214	0	10	165										C	39797480	G	C	39797480	3	2	40	1	0	0	0	0	1	0	0	0	9144	1281	45	1	5311	1	MACF1	1	39797480	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1600306	39797480	209453141	26	9699										
MACF1	23499	broad.mit.edu	37	chr1	39799895	39799895	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagaacttaaacatccatcaGatttttaatcctgaaacgaa	5	8	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39799895G>T	uc010oiu.1	+	1	3086	c.2955G>T	c.(2953-2955)CAG>CAT	p.Q985H	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2550					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACATCCATCAGATTTTTAATC	0.378													1	0	7.38237e-10	0.00632	7.64262e-10	26	248										T	39799895	G	T	39799895	3	4	40	1	0	0	0	0	1	0	0	0	9144	933	33	3	7726	3	MACF1	1	39799895	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2415	39799895	209450726	27	9700										
MACF1	23499	broad.mit.edu	37	chr1	39800966	39800966	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaagtggctagaaataacatGggaaatgatacaaatgaaga	11	3	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39800966G>C	uc010oiu.1	+	1	4157	c.4026G>C	c.(4024-4026)ATG>ATC	p.M1342I	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2907					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAATAACATGGGAAATGATA	0.338													0	0	0	0.008871	0	20	214										C	39800966	G	C	39800966	3	2	40	1	0	0	0	0	1	0	0	0	9144	1348	47	4	8797	4	MACF1	1	39800966	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1071	39800966	209449655	28	9701										
KIAA0754	643314	broad.mit.edu	37	chr1	39876601	39876601	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	actgccaggactttagatttCagcagcacagtgcaaaccct	8	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:39876601C>T	uc009vvt.1	+	1	1426	c.664C>T	c.(664-666)CAG>TAG	p.Q222*	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	86	13 X 13 AA approximate tandem repeat of P-T-S-P-A-A-A-V-P-T-P-E-E.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTTTAGATTTCAGCAGCACAG	0.433											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	31	144										T	39876601	C	T	39876601	4	4	40	1	0	0	0	0	0	1	0	0	8192	827	29	1	666	1	KIAA0754	1	39876601	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	75635	39876601	209374020	29	9702										
CCDC30	728621	broad.mit.edu	37	chr1	43042700	43042700	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctacctctagataaagattGaactaaagcatgcccaacag	6	10	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:43042700G>A	uc009vwk.1	+	7	975	c.865G>A	c.(865-867)GAA>AAA	p.E289K	CCDC30_uc001chm.2_5'UTR|CCDC30_uc001chn.2_Missense_Mutation_p.E78K|CCDC30_uc010oju.1_RNA|CCDC30_uc001chp.2_Missense_Mutation_p.E103K	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	289	Potential.										0						GATAAAGATTGAACTAAAGCA	0.388													0	0	0	0.001855	0	13	53										A	43042700	G	A	43042700	3	1	40	1	0	0	0	0	1	0	0	0	2805	1291	45	1	887	1	CCDC30	1	43042700	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3166099	43042700	206207921	30	9703										
IPO13	9670	broad.mit.edu	37	chr1	44424218	44424218	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatccttaagaacctgcactCgcttatctcaccctatatcc	4	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:44424218C>G	uc001ckx.2	+	10	2630	c.1835C>G	c.(1834-1836)TCG>TGG	p.S612W		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	612	HEAT 10.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				AACCTGCACTCGCTTATCTCA	0.562													0	0	0	0.003163	0	14	186										G	44424218	C	G	44424218	3	3	40	1	0	0	0	0	1	0	0	0	7794	893	31	1	1873	1	IPO13	1	44424218	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1381518	44424218	204826403	31	9704										
ERI3	79033	broad.mit.edu	37	chr1	44785309	44785309	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agggcccttacctctgtacaGaatggggtaagctgtggatg	14	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:44785309G>C	uc001clt.2	-	4	838	c.597C>G	c.(595-597)TTC>TTG	p.F199L	ERI3_uc010okv.1_Missense_Mutation_p.F22L|ERI3_uc009vxg.2_Missense_Mutation_p.F199L|ERI3_uc010okw.1_Missense_Mutation_p.F121L|ERI3_uc001clu.2_Missense_Mutation_p.F121L	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	199	Exonuclease.					intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						CCTCTGTACAGAATGGGGTAA	0.512													0	0	0	0.00632	0	25	169										C	44785309	G	C	44785309	3	2	40	1	0	0	0	0	1	0	0	0	5229	933	33	1	440	1	ERI3	1	44785309	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	361091	44785309	204465312	32	9705										
PLK3	1263	broad.mit.edu	37	chr1	45269324	45269324	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccggtttggtgagcggcctCatgcgcacatccgttggcca	13	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:45269324C>T	uc001cmn.2	+	9	1225	c.1125C>T	c.(1123-1125)CTC>CTT	p.L375L	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	375						membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGAGCGGCCTCATGCGCACAT	0.617													0	0	0	0.00308	0	7	22										T	45269324	C	T	45269324	2	4	40	1	0	0	0	0	0	0	0	1	12097	813	29	1		1	PLK3	1	45269324	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	484015	45269324	203981297	33	9706										
ZSWIM5	57643	broad.mit.edu	37	chr1	45484612	45484612	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taggccaggttaagatggctCatggccaatgaggccagctt	13	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:45484612C>G	uc001cnd.2	-	14	3300	c.3072G>C	c.(3070-3072)ATG>ATC	p.M1024I		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	1024							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TAAGATGGCTCATGGCCAATG	0.567											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	87										G	45484612	C	G	45484612	3	3	40	1	0	0	0	0	1	0	0	0	18241	826	29	1	489	1	ZSWIM5	1	45484612	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	215288	45484612	203766009	34	9707										
AKR1A1	10327	broad.mit.edu	37	chr1	46034629	46034629	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagcggaaagtgatctgcatCcccaaaagtatcactccttc	7	13	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:46034629C>T	uc001cod.2	+	8	1247	c.783C>T	c.(781-783)ATC>ATT	p.I261I	AKR1A1_uc001coe.2_Silent_p.I261I|AKR1A1_uc001cof.2_Silent_p.I67I|AKR1A1_uc001cog.2_RNA	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	261	NADP (By similarity).				glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TGATCTGCATCCCCAAAAGTA	0.453													0	0	0	0.01441	0	155	114										T	46034629	C	T	46034629	2	4	40	1	0	0	0	0	0	0	0	1	465	845	30	1		1	AKR1A1	1	46034629	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	550017	46034629	203215992	35	9708										
DMBX1	127343	broad.mit.edu	37	chr1	46976269	46976269	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagaagactcactacccagaTgtggtgatgcgtgagaggct	13	9	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:46976269T>G	uc001cpx.2	+	2	306	c.291T>G	c.(289-291)GAT>GAG	p.D97E	DMBX1_uc001cpw.2_Missense_Mutation_p.D92E	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	97	Homeobox.|Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACTACCCAGATGTGGTGATGC	0.597													0	0	0	0.00632	0	26	35										G	46976269	T	G	46976269	3	3	40	1	0	0	0	0	1	0	0	0	4578	1461	51	5	297	5	DMBX1	1	46976269	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	941640	46976269	202274352	36	9709										
MYSM1	114803	broad.mit.edu	37	chr1	59142623	59142623	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccaaaattgattgctcctatCaattcgaggtatgtatgaat	7	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:59142623C>T	uc009wab.1	-	9	1388	c.1365G>A	c.(1363-1365)TTG>TTA	p.L455L	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	455	SWIRM.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TTGCTCCTATCAATTCGAGGT	0.348													0	0	0	0.01441	0	53	110										T	59142623	C	T	59142623	2	4	40	1	0	0	0	0	0	0	0	1	10101	825	29	1		1	MYSM1	1	59142623	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	12166354	59142623	190107998	37	9710										
DOCK7	85440	broad.mit.edu	37	chr1	63024891	63024891	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaatttgtcaagataaggatCctaaaacaaagaataaacaa	5	5	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:63024891C>T	uc001daq.2	-	20	2234	c.2200G>A	c.(2200-2202)GAT>AAT	p.D734N	DOCK7_uc001dan.2_Missense_Mutation_p.D626N|DOCK7_uc001dao.2_Missense_Mutation_p.D626N|DOCK7_uc001dap.2_Missense_Mutation_p.D734N	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	734	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGATAAGGATCCTAAAACAAA	0.363													0	0	0	0.004482	0	7	34										T	63024891	C	T	63024891	3	4	40	1	0	0	0	0	1	0	0	0	4692	869	30	1	4249	1	DOCK7	1	63024891	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3882268	63024891	186225730	38	9711										
ANGPTL3	27329	broad.mit.edu	37	chr1	63066796	63066796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acccacagaaatttctctatCttccaagccaagagcaccaa	4	14	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:63066796C>G	uc001das.1	+	3	701	c.650C>G	c.(649-651)TCT>TGT	p.S217C	DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc001daq.2_Intron|DOCK7_uc009wah.1_Intron	NM_014495	NP_055310	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3 precursor	217					acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity				0						ATTTCTCTATCTTCCAAGCCA	0.343													0	0	0	0.012319	0	22	131										G	63066796	C	G	63066796	3	3	40	1	0	0	0	0	1	0	0	0	615	913	32	1	660	1	ANGPTL3	1	63066796	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	41905	63066796	186183825	39	9712										
MIER1	57708	broad.mit.edu	37	chr1	67411832	67411833	+	Splice_Site	DNP	GG	GG	TT													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttttgaaatattccttaccaGgaggttcagcaacatcagat							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:67411832_67411833GG>TT	uc001dde.2	+	4	328	c.194_splice	c.e4-1	p.G65_splice	MIER1_uc001dda.3_Splice_Site_p.E90_splice|MIER1_uc010opf.1_Splice_Site_p.G29_splice|MIER1_uc009way.2_Splice_Site_p.G29_splice|MIER1_uc001ddc.2_Splice_Site_p.G65_splice|MIER1_uc001ddh.2_Intron|MIER1_uc001ddf.2_Splice_Site_p.G29_splice|MIER1_uc001ddg.2_Splice_Site|MIER1_uc010opg.1_Splice_Site_p.G29_splice|MIER1_uc001ddj.1_Splice_Site_p.G12_splice|MIER1_uc001ddi.2_Splice_Site_p.G12_splice	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b						positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						TTCCTTACCAGGAGGTTCAGCA	0.317													0	0	0	0.004672	0	26	90										TT	67411833	GG	TT	67411832	5	4	40	1	0	0	0	0	0	0	1	0	9580	1014	35	4	284	4	MIER1	1	67411832	Splice_Site	DNP	GG	TCGA-DK-A1A3-01A-11D-A13W-08	4345036	67411832	181838789	40	9713										
ANKRD13C	81573	broad.mit.edu	37	chr1	70728465	70728465	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tatagtaaagatggagccatCaaattcatcgtatcgaaact	7	7	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:70728465C>T	uc001dex.3	-	13	1887	c.1561G>A	c.(1561-1563)GAT>AAT	p.D521N	ANKRD13C_uc009wbk.2_Missense_Mutation_p.D486N	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	521					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						ATGGAGCCATCAAATTCATCG	0.408													0	0	0	0.01441	0	61	138										T	70728465	C	T	70728465	3	4	40	1	0	0	0	0	1	0	0	0	643	826	29	1	68	1	ANKRD13C	1	70728465	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3316633	70728465	178522156	41	9714										
FUBP1	8880	broad.mit.edu	37	chr1	78430866	78430866	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcgccatgatggaagccagGagctggtcttcctttttcaa	10	10	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:78430866G>A	uc001dii.2	-	8	612	c.523C>T	c.(523-525)CCT>TCT	p.P175S	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.P196S	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	175					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						TGGAAGCCAGGAGCTGGTCTT	0.418													0	0	0	0.009535	0	30	141										A	78430866	G	A	78430866	3	1	40	1	0	0	0	0	1	0	0	0	6092	1174	41	1	1463	1	FUBP1	1	78430866	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7702401	78430866	170819755	42	9715										
DNASE2B	58511	broad.mit.edu	37	chr1	84867740	84867740	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggaaggacattacaacagctAtatgaagcatatgcctctaa	8	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:84867740A>G	uc001djt.1	+	2	315	c.282A>G	c.(280-282)CTA>CTG	p.L94L		NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta isoform 1 precursor	94					DNA metabolic process	lysosome	deoxyribonuclease II activity				0				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TACAACAGCTATATGAAGCAT	0.363								Direct_reversal_of_damage					0	0	0	0.001168	0	6	28										G	84867740	A	G	84867740	2	3	40	1	0	0	0	0	0	0	0	1	4665	436	16	5		5	DNASE2B	1	84867740	Silent	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	6436874	84867740	164382881	43	9716										
COL24A1	255631	broad.mit.edu	37	chr1	86426951	86426951	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgtttcaccaatttttccaAtatttccttgatctcctact	2	12	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:86426951A>T	uc001dlj.2	-	24	2585	c.2543T>A	c.(2542-2544)ATT>AAT	p.I848N	COL24A1_uc001dli.2_Translation_Start_Site|COL24A1_uc010osd.1_Missense_Mutation_p.I148N|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	848	Collagen-like 5.			GYAGEPGPEGLKGEVGDQGNIG -> ITVFATLYSFLTGRS RRSRKYW (in Ref. 5; BAD92923).	cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		AATTTTTCCAATATTTCCTTG	0.289													0	0	0	0.003163	0	15	96										T	86426951	A	T	86426951	3	4	40	1	0	0	0	0	1	0	0	0	3683	101	4	5	2749	5	COL24A1	1	86426951	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	1559211	86426951	162823670	44	9717										
ZNF644	84146	broad.mit.edu	37	chr1	91406420	91406420	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacttgctttctgtggtgtaGacagctgaagatcagctgct	12	8	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:91406420G>A	uc001dnw.2	-	3	633	c.491C>T	c.(490-492)TCT>TTT	p.S164F	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.S164F	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CTGTGGTGTAGACAGCTGAAG	0.403													0	0	0	0.005443	0	29	150										A	91406420	G	A	91406420	3	1	40	1	0	0	0	0	1	0	0	0	18057	942	33	1	3508	1	ZNF644	1	91406420	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4979469	91406420	157844201	45	9718										
MTF2	22823	broad.mit.edu	37	chr1	93580289	93580289	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctgtacaatatgtcaagaaGagtattcagaagctcccaat	7	8	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:93580289G>C	uc009wdj.2	+	4	623	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	MTF2_uc001dph.2_Missense_Mutation_p.E9Q|MTF2_uc010oth.1_Missense_Mutation_p.E9Q|MTF2_uc009wdk.2_Missense_Mutation_p.E111Q|MTF2_uc001dpi.3_5'UTR|MTF2_uc010oti.1_Missense_Mutation_p.E9Q|MTF2_uc001dpj.3_Missense_Mutation_p.E9Q|MTF2_uc001dpl.3_Missense_Mutation_p.E9Q	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	111	PHD-type 1.					nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		ATGTCAAGAAGAGTATTCAGA	0.328													0	0	0	0.013537	0	10	55										C	93580289	G	C	93580289	3	2	40	1	0	0	0	0	1	0	0	0	9923	943	33	1	345	1	MTF2	1	93580289	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2173869	93580289	155670332	46	9719										
CNN3	1266	broad.mit.edu	37	chr1	95363303	95363303	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccttctgtgtggatctaatAatcaatgccttggtcgctat	8	9	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:95363303A>C	uc010otw.1	-	8	1067	c.985T>G	c.(985-987)TAT>GAT	p.Y329D	CNN3_uc010otv.1_Missense_Mutation_p.Y288D|CNN3_uc001dqz.3_Missense_Mutation_p.Y329D|CNN3_uc010otx.1_Missense_Mutation_p.Y283D	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	329	Asp/Glu-rich (acidic).				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		TGGATCTAATAATCAATGCCT	0.398													0	0	0	0.013726	0	33	154										C	95363303	A	C	95363303	3	2	40	1	0	0	0	0	1	0	0	0	3611	362	13	5	8	5	CNN3	1	95363303	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	1783014	95363303	153887318	47	9720										
CNN3	1266	broad.mit.edu	37	chr1	95363318	95363318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctaataatcaatgccttggtCgctatattggtaatctctgg	8	8	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:95363318C>T	uc010otw.1	-	8	1052	c.970G>A	c.(970-972)GAC>AAC	p.D324N	CNN3_uc010otv.1_Missense_Mutation_p.D283N|CNN3_uc001dqz.3_Missense_Mutation_p.D324N|CNN3_uc010otx.1_Missense_Mutation_p.D278N	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	324	Asp/Glu-rich (acidic).				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		ATGCCTTGGTCGCTATATTGG	0.398													0	0	0	0.006999	0	39	175										T	95363318	C	T	95363318	3	4	40	1	0	0	0	0	1	0	0	0	3611	884	31	1	23	1	CNN3	1	95363318	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	15	95363318	153887303	48	9721										
LPPR5	163404	broad.mit.edu	37	chr1	99387500	99387500	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacatctgaccaatgatttcGatattctgctactctgttga	6	9	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:99387500G>A	uc001dsb.2	-	4	958	c.736C>T	c.(736-738)CGA>TGA	p.R246*	LPPR5_uc001dsc.2_Nonsense_Mutation_p.R246*	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	246						integral to membrane	hydrolase activity				0						CAATGATTTCGATATTCTGCT	0.368													0	0	0	0.004878	0	35	116										A	99387500	G	A	99387500	4	1	40	1	0	0	0	0	0	1	0	0	8928	1066	37	1	241	1	LPPR5	1	99387500	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4024182	99387500	149863121	49	9722										
FRRS1	391059	broad.mit.edu	37	chr1	100212977	100212977	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcctttaaatggatgccctGacaaagtaactgagaaaaag	9	7	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:100212977G>A	uc001dsh.1	-	4	808	c.206C>T	c.(205-207)TCA>TTA	p.S69L		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	69	Reelin.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)		TGGATGCCCTGACAAAGTAAC	0.378													0	0	0	0.008361	0	29	115										A	100212977	G	A	100212977	3	1	40	1	0	0	0	0	1	0	0	0	6060	1294	45	1	1730	1	FRRS1	1	100212977	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	825477	100212977	149037644	50	9723										
FNDC7	163479	broad.mit.edu	37	chr1	109276098	109276098	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtatacactgtgatggtctCaccagttgctaaaacaggat	9	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:109276098C>T	uc001dvx.2	+	10	2084	c.2084C>T	c.(2083-2085)TCA>TTA	p.S695L	FNDC7_uc010ova.1_Missense_Mutation_p.S462L	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	696	Fibronectin type-III 8.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		GTGATGGTCTCACCAGTTGCT	0.423													0	0	0	0.012319	0	23	94										T	109276098	C	T	109276098	3	4	40	1	0	0	0	0	1	0	0	0	5973	838	29	1	2122	1	FNDC7	1	109276098	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9063121	109276098	139974523	51	9724										
CSF1	1435	broad.mit.edu	37	chr1	110466437	110466437	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccctgctcagagaccccccGgagccaggctctcccaggat	11	18	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:110466437G>A	uc001dyu.2	+	6	1607	c.1194G>A	c.(1192-1194)CCG>CCA	p.P398P	CSF1_uc001dyt.2_Intron|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Silent_p.P398P	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	398	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGACCCCCCGGAGCCAGGCT	0.667													0	0	0	0.010729	0	9	44										A	110466437	G	A	110466437	2	1	40	1	0	0	0	0	0	0	0	1	3931	1103	39	2		2	CSF1	1	110466437	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1190339	110466437	138784184	52	9725										
RBM15	64783	broad.mit.edu	37	chr1	110884629	110884629	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggctgtgcctggaagttctGacagccggtcctcctcttcc	11	14	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:110884629G>A	uc001dzl.1	+	1	2685	c.2602G>A	c.(2602-2604)GAC>AAC	p.D868N	RBM15_uc001dzm.1_Missense_Mutation_p.D868N|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	868	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGGAAGTTCTGACAGCCGGTC	0.512			T	MKL1	acute megakaryocytic leukemia								0	0	0	0.00245	0	13	67										A	110884629	G	A	110884629	3	1	40	1	0	0	0	0	1	0	0	0	13116	1290	45	1	2604	1	RBM15	1	110884629	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	418192	110884629	138365992	53	9726										
DENND2D	79961	broad.mit.edu	37	chr1	111730906	111730906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccttgcccatttgcctcccGcttgatataggaagcataat	8	12	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:111730906G>A	uc001eak.1	-	11	1386	c.1186C>T	c.(1186-1188)CGG>TGG	p.R396W	DENND2D_uc001eal.1_Missense_Mutation_p.R393W	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	396	dDENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTTGCCTCCCGCTTGATATAG	0.473													0	0	0	0.004656	0	26	114										A	111730906	G	A	111730906	3	1	40	1	0	0	0	0	1	0	0	0	4431	1086	38	2	237	2	DENND2D	1	111730906	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	846277	111730906	137519715	54	9727										
WDR77	79084	broad.mit.edu	37	chr1	111983905	111983905	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagaggttctgtgggcacaaCgtggtggacgacctgatggt	17	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:111983905C>T	uc001ebb.2	-	10	1015	c.976G>A	c.(976-978)GTT>ATT	p.V326I	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Missense_Mutation_p.V262I	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	326				LTTVGWDHQVVHHVVPTEPLPAPGPASVTE -> DLQVLLS RLDLRQKASPP (in Ref. 7; AAH09411).	ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GTGGGCACAACGTGGTGGACG	0.537													0	0	0	0.010504	0	22	55										T	111983905	C	T	111983905	3	4	40	1	0	0	0	0	1	0	0	0	17324	536	19	2	56	2	WDR77	1	111983905	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	252999	111983905	137266716	55	9728										
MOV10	4343	broad.mit.edu	37	chr1	113217604	113217604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcgagagtttcctggtcgttCggggactggacatggagaca	15	8	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:113217604C>T	uc001eck.2	+	2	340	c.70C>T	c.(70-72)CGG>TGG	p.R24W	MOV10_uc001ecl.2_Missense_Mutation_p.R24W|MOV10_uc001ecn.2_Missense_Mutation_p.R24W|MOV10_uc001ecm.2_5'UTR|MOV10_uc009wgj.1_5'UTR	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	24					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CCTGGTCGTTCGGGGACTGGA	0.667													0	0	0	0.006214	0	8	47										T	113217604	C	T	113217604	3	4	40	1	0	0	0	0	1	0	0	0	9718	875	31	1	72	1	MOV10	1	113217604	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1233699	113217604	136033017	56	9729										
MOV10	4343	broad.mit.edu	37	chr1	113234326	113234326	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagttaagtatggcgctgggGacatactacccacctccccg	11	13	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:113234326G>T	uc001eck.2	+	6	1146	c.876G>T	c.(874-876)GGG>GGT	p.G292G	MOV10_uc001ecl.2_Silent_p.G292G|MOV10_uc001ecn.2_Silent_p.G292G|MOV10_uc001ecm.2_Silent_p.G232G|MOV10_uc009wgj.1_Silent_p.G232G	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	292					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TGGCGCTGGGGACATACTACC	0.542													1	0	8.10497e-08	0.010504	8.35144e-08	20	79										T	113234326	G	T	113234326	2	4	40	1	0	0	0	0	0	0	0	1	9718	1161	41	3		3	MOV10	1	113234326	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	16722	113234326	136016295	57	9730										
LRIG2	9860	broad.mit.edu	37	chr1	113657463	113657463	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cattgttatttaccacatgaGaaggaaaaatgaagactata	7	5	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:113657463G>A	uc001edf.1	+	15	2693	c.2495G>A	c.(2494-2496)AGA>AAA	p.R832K	LRIG2_uc009wgn.1_Missense_Mutation_p.R729K	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	832	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		TACCACATGAGAAGGAAAAAT	0.398													0	0	0	0.008871	0	20	96										A	113657463	G	A	113657463	3	1	40	1	0	0	0	0	1	0	0	0	8945	942	33	1	2553	1	LRIG2	1	113657463	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	423137	113657463	135593158	58	9731										
OLFML3	56944	broad.mit.edu	37	chr1	114524373	114524373	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tataagctggagatgaggaaGaaagaggaggaggtttgagg	18	1	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:114524373G>A	uc001eer.1	+	3	1312	c.1203G>A	c.(1201-1203)AAG>AAA	p.K401K	OLFML3_uc001ees.1_Silent_p.K381K|OLFML3_uc001eet.1_Silent_p.K257K	NM_020190	NP_064575	Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3 precursor	401	Olfactomedin-like.				multicellular organismal development	extracellular region					0	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGATGAGGAAGAAAGAGGAGG	0.458													0	0	0	0.004482	0	8	26										A	114524373	G	A	114524373	2	1	40	1	0	0	0	0	0	0	0	1	10859	933	33	1		1	OLFML3	1	114524373	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	866910	114524373	134726248	59	9732										
APH1A	51107	broad.mit.edu	37	chr1	150238976	150238976	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggagggaccctccagctgtGatgaaggcccagagccccat	13	14	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:150238976G>C	uc001ety.1	-	6	1012	c.690C>G	c.(688-690)ATC>ATG	p.I230M	APH1A_uc010pbx.1_Missense_Mutation_p.I160M|APH1A_uc001etz.1_Missense_Mutation_p.I230M|APH1A_uc001eua.1_Missense_Mutation_p.I230M|APH1A_uc010pby.1_Missense_Mutation_p.I173M|APH1A_uc001eub.1_Missense_Mutation_p.I114M|APH1A_uc010pbz.1_Missense_Mutation_p.I114M	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	230	Helical; Name=7; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCCAGCTGTGATGAAGGCCC	0.567													0	0	0	0.001168	0	6	37										C	150238976	G	C	150238976	3	2	40	1	0	0	0	0	1	0	0	0	771	1280	45	1	126	1	APH1A	1	150238976	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	35714603	150238976	99011645	60	9733										
APH1A	51107	broad.mit.edu	37	chr1	150240466	150240466	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcatctgaccggtcggtcaCatggaccaagatgaaccaga	12	11	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:150240466C>T	uc001ety.1	-	2	497	c.175G>A	c.(175-177)GTG>ATG	p.V59M	APH1A_uc010pbx.1_Intron|APH1A_uc001etz.1_Missense_Mutation_p.V59M|APH1A_uc001eua.1_Missense_Mutation_p.V59M|APH1A_uc010pby.1_Intron|APH1A_uc001eub.1_Intron|APH1A_uc010pbz.1_Intron	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	59	Lumenal (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CGGTCGGTCACATGGACCAAG	0.542													0	0	0	0.00632	0	29	49										T	150240466	C	T	150240466	3	4	40	1	0	0	0	0	1	0	0	0	771	478	17	2	657	2	APH1A	1	150240466	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1490	150240466	99010155	61	9734										
FLG	2312	broad.mit.edu	37	chr1	152281379	152281379	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcacttgatcttgcctgttCatgggatgacgcagcctgtc	11	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:152281379C>G	uc001ezu.1	-	3	6019	c.5983G>C	c.(5983-5985)GAA>CAA	p.E1995Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1995	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGCCTGTTCATGGGATGAC	0.567									Ichthyosis				0	0	0	0.01441	0	96	819										G	152281379	C	G	152281379	3	3	40	1	0	0	0	0	1	0	0	0	5922	835	29	1	6206	1	FLG	1	152281379	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2040913	152281379	96969242	62	9735										
FLG2	388698	broad.mit.edu	37	chr1	152327225	152327225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgaactagacccatgttgacCatagccagatgactgacttg	9	10	0	6			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:152327225C>T	uc001ezw.3	-	3	3110	c.3037G>A	c.(3037-3039)GGT>AGT	p.G1013S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1013	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGACCATAGCCAGAT	0.483													0	0	0	0.01441	0	167	367										T	152327225	C	T	152327225	3	4	40	1	0	0	0	0	1	0	0	0	5923	594	21	2	4142	2	FLG2	1	152327225	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	45846	152327225	96923396	63	9736										
KPRP	448834	broad.mit.edu	37	chr1	152732377	152732377	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgcatcccaatctcaaactTcctctgttcaaagccaggct	5	15	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:152732377T>C	uc001fal.1	+	2	371	c.313T>C	c.(313-315)TCC>CCC	p.S105P		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	105	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTCAAACTTCCTCTGTTCA	0.537													0	0	0	0.01441	0	115	274										C	152732377	T	C	152732377	3	2	40	1	0	0	0	0	1	0	0	0	8436	1783	62	5	315	5	KPRP	1	152732377	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	405152	152732377	96518244	64	9737										
NUP210L	91181	broad.mit.edu	37	chr1	154000004	154000004	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gttggtatggagtttgagctGagaatttataggcatcagaa	13	3	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:154000004G>A	uc001fdw.2	-	29	3997	c.3925C>T	c.(3925-3927)CAG>TAG	p.Q1309*	NUP210L_uc009woq.2_Nonsense_Mutation_p.Q218*|NUP210L_uc010peh.1_Nonsense_Mutation_p.Q1309*	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1309						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTTTGAGCTGAGAATTTATA	0.368													0	0	0	0.004289	0	36	101										A	154000004	G	A	154000004	4	1	40	1	0	0	0	0	0	1	0	0	10761	1299	45	1	1789	1	NUP210L	1	154000004	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1267627	154000004	95250617	65	9738										
THBS3	7059	broad.mit.edu	37	chr1	155177629	155177629	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatgtgaaaaagcaaaggagGagaagagccagggccccccg	15	9	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:155177629G>A	uc001fix.2	-	1	62	c.39C>T	c.(37-39)CTC>CTT	p.L13L	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Silent_p.L13L|THBS3_uc001fiz.2_Silent_p.L13L|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Silent_p.L13L|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_Intron|THBS3_uc009wqj.1_Intron|MTX1_uc001fjb.2_5'Flank|MTX1_uc001fjc.2_5'Flank	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	13					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGCAAAGGAGGAGAAGAGCCA	0.607													0	0	0	0.006214	0	9	52										A	155177629	G	A	155177629	2	1	40	1	0	0	0	0	0	0	0	1	15852	1161	41	1		1	THBS3	1	155177629	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1177625	155177629	94072992	66	9739										
RIT1	6016	broad.mit.edu	37	chr1	155880497	155880497	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcactagtttgtactcccgtGagagcccagcggggctgcta	12	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:155880497G>A	uc001fmh.1	-	2	243	c.56C>T	c.(55-57)TCA>TTA	p.S19L	RIT1_uc010pgr.1_Intron	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	19					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			GTACTCCCGTGAGAGCCCAGC	0.527													0	0	0	0.01441	0	43	138										A	155880497	G	A	155880497	3	1	40	1	0	0	0	0	1	0	0	0	13386	1294	45	1	623	1	RIT1	1	155880497	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	702868	155880497	93370124	67	9740										
SEMA4A	64218	broad.mit.edu	37	chr1	156127890	156127890	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccagccagtgacagaaaaaaGagtgaatgtgcctttaagaa	10	7	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:156127890G>C	uc001fnl.2	+	4	434	c.330G>C	c.(328-330)AAG>AAC	p.K110N	SEMA4A_uc009wrq.2_Missense_Mutation_p.K110N|SEMA4A_uc001fnm.2_Missense_Mutation_p.K110N|SEMA4A_uc001fnn.2_Missense_Mutation_p.K11N|SEMA4A_uc001fno.2_Missense_Mutation_p.K110N	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	110	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					ACAGAAAAAAGAGTGAATGTG	0.522													0	0	0	0.010729	0	9	37										C	156127890	G	C	156127890	3	2	40	1	0	0	0	0	1	0	0	0	14031	933	33	1	340	1	SEMA4A	1	156127890	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	247393	156127890	93122731	68	9741										
ARHGEF11	9826	broad.mit.edu	37	chr1	156911698	156911698	+	Frame_Shift_Del	DEL	G	G	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggctggctcccggggacctGggggtggaggatggacgggc							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:156911698delG	uc001fqo.2	-	33	4330	c.3290delC	c.(3289-3291)CCAfs	p.P1097fs	ARHGEF11_uc010phu.1_Frame_Shift_Del_p.P513fs|ARHGEF11_uc001fqn.2_Frame_Shift_Del_p.P1137fs	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1097	Poly-Pro.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGGGGACCTGGGGGTGGAGG	0.647																		14	81	---	---								-	156911698	G	-	156911698	7	5	40	1	0	1	0	1	0	0	0	0	896	1348	47	0	1310	0	ARHGEF11	1	156911698	Frame_Shift_Del	DEL	G	TCGA-DK-A1A3-01A-11D-A13W-08	783808	156911698	92338923	69	9742										
ARHGEF11	9826	broad.mit.edu	37	chr1	156918212	156918212	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgcgagagcggggcacgttCtctgcctttcgagaccgttt	13	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:156918212C>T	uc001fqo.2	-	22	2924	c.1884G>A	c.(1882-1884)GAG>GAA	p.E628E	ARHGEF11_uc010phu.1_Silent_p.E44E|ARHGEF11_uc001fqn.2_Silent_p.E668E|ARHGEF11_uc001fqp.1_Silent_p.E147E	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	628					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGGGCACGTTCTCTGCCTTTC	0.602													0	0	0	0.006122	0	16	75										T	156918212	C	T	156918212	2	4	40	1	0	0	0	0	0	0	0	1	896	912	32	1		1	ARHGEF11	1	156918212	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6514	156918212	92332409	70	9743										
SPTA1	6708	broad.mit.edu	37	chr1	158641938	158641938	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcatactgacgatgacgctCgtcccacagttccagcaggg	10	14	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:158641938C>T	uc001fst.1	-	11	1598	c.1399G>A	c.(1399-1401)GAG>AAG	p.E467K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	467	Spectrin 5.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CGATGACGCTCGTCCCACAGT	0.423													0	0	0	0.00245	0	14	64										T	158641938	C	T	158641938	3	4	40	1	0	0	0	0	1	0	0	0	15115	893	31	1	6028	1	SPTA1	1	158641938	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1723726	158641938	90608683	71	9744										
OR6N2	81442	broad.mit.edu	37	chr1	158747226	158747226	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tataccacaactccaagaagGaaagaacactgacaaagtgg	8	9	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:158747226G>A	uc010pir.1	-	1	200	c.200C>T	c.(199-201)TCC>TTC	p.S67F		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					CTCCAAGAAGGAAAGAACACT	0.443													0	0	0	0.005443	0	28	211										A	158747226	G	A	158747226	3	1	40	1	0	0	0	0	1	0	0	0	11207	1174	41	1	756	1	OR6N2	1	158747226	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	105288	158747226	90503395	72	9745										
POGK	57645	broad.mit.edu	37	chr1	166818747	166818747	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggcaagcttgggttggtgtCgaagaatgatgagaaggtat	16	3	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:166818747C>G	uc001gdt.1	+	5	1051	c.931C>G	c.(931-933)CGA>GGA	p.R311G	POGK_uc010ple.1_Missense_Mutation_p.R226G|POGK_uc010plf.1_Missense_Mutation_p.R193G	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	311	HTH CENPB-type.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGGTTGGTGTCGAAGAATGAT	0.547													0	0	0	0.003163	0	14	95										G	166818747	C	G	166818747	3	3	40	1	0	0	0	0	1	0	0	0	12185	876	31	1	945	1	POGK	1	166818747	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	8071521	166818747	82431874	73	9746										
ADCY10	55811	broad.mit.edu	37	chr1	167852770	167852770	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctggatggctgggcctatctCttctgctttgtcttggtctt	11	10	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:167852770C>G	uc001ger.2	-	9	1223	c.925G>C	c.(925-927)GAG>CAG	p.E309Q	ADCY10_uc009wvk.2_Missense_Mutation_p.E217Q|ADCY10_uc010plj.1_Missense_Mutation_p.E156Q|ADCY10_uc009wvl.2_Missense_Mutation_p.E308Q|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	309	Guanylate cyclase 2.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GGGCCTATCTCTTCTGCTTTG	0.438													0	0	0	0.01441	0	54	207										G	167852770	C	G	167852770	3	3	40	1	0	0	0	0	1	0	0	0	293	922	32	1	4007	1	ADCY10	1	167852770	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1034023	167852770	81397851	74	9747										
F5	2153	broad.mit.edu	37	chr1	169494148	169494148	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccattggcatcctacagtcTatgaaaaacagaaaaaaaat	5	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:169494148T>C	uc001ggg.1	-	19	5862	c.5717_splice	c.e19-1	p.D1906_splice		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor						cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCCTACAGTCTATGAAAAACA	0.328													0	0	0	0.00623	0	40	91										C	169494148	T	C	169494148	5	2	40	1	0	0	0	0	0	0	1	0	5348	1536	53	5	987	5	F5	1	169494148	Splice_Site	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	1641378	169494148	79756473	75	9748										
ZBTB37	84614	broad.mit.edu	37	chr1	173839578	173839578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatgagtacagtctccatttCagtcatcaagaaccctactg	7	11	4	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:173839578C>T	uc009wwp.1	+	3	491	c.215C>T	c.(214-216)TCA>TTA	p.S72L	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|SNORD74_uc001gjo.1_5'Flank|ZBTB37_uc001gjp.1_Missense_Mutation_p.S72L|ZBTB37_uc001gjq.3_Missense_Mutation_p.S72L|ZBTB37_uc001gjr.2_Missense_Mutation_p.S72L	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	72	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCTCCATTTCAGTCATCAAG	0.483													0	0	0	0.00623	0	42	80										T	173839578	C	T	173839578	3	4	40	1	0	0	0	0	1	0	0	0	17535	838	29	1	217	1	ZBTB37	1	173839578	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4345430	173839578	75411043	76	9749										
DHX9	1660	broad.mit.edu	37	chr1	182822501	182822501	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgggcccacctgggaccgagGagccaacttgaaggattact	13	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:182822501G>A	uc001gpr.2	+	5	588	c.425G>A	c.(424-426)GGA>GAA	p.G142E	DHX9_uc001gps.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	142	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TGGGACCGAGGAGCCAACTTG	0.448													0	0	0	0.01441	0	48	142										A	182822501	G	A	182822501	3	1	40	1	0	0	0	0	1	0	0	0	4516	1174	41	1	439	1	DHX9	1	182822501	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	8982923	182822501	66428120	77	9750										
SMG7	9887	broad.mit.edu	37	chr1	183518386	183518386	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agagctcatgtcacattcatCctctttcctgtccctcaccg	5	16	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:183518386C>T	uc001gqg.2	+	18	2908	c.2786C>T	c.(2785-2787)TCC>TTC	p.S929F	SMG7_uc001gqf.2_Missense_Mutation_p.S933F|SMG7_uc001gqh.2_Missense_Mutation_p.S883F|SMG7_uc001gqi.2_Missense_Mutation_p.S841F|SMG7_uc010poc.1_Missense_Mutation_p.S937F	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	929	Ser-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCACATTCATCCTCTTTCCTG	0.388													0	0	0	0.005524	0	35	78										T	183518386	C	T	183518386	3	4	40	1	0	0	0	0	1	0	0	0	14798	855	30	1	3010	1	SMG7	1	183518386	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	695885	183518386	65732235	78	9751										
HMCN1	83872	broad.mit.edu	37	chr1	186044020	186044020	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggattttgatgtgaatattCaaggtaatactaattgctta	8	3	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:186044020C>G	uc001grq.1	+	53	8516	c.8287C>G	c.(8287-8289)CAA>GAA	p.Q2763E		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2763	Ig-like C2-type 25.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGTGAATATTCAAGGTAATAC	0.284													0	0	0	0.014323	0	20	91										G	186044020	C	G	186044020	3	3	40	1	0	0	0	0	1	0	0	0	7220	827	29	1	8497	1	HMCN1	1	186044020	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2525634	186044020	63206601	79	9752										
ASPM	259266	broad.mit.edu	37	chr1	197070599	197070599	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcattgtgttgaaatactttCtgtttctttttatttgctct	5	6	4	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:197070599C>T	uc001gtu.2	-	18	8039	c.7782G>A	c.(7780-7782)CAG>CAA	p.Q2594Q	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Silent_p.Q442Q	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2594					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GAAATACTTTCTGTTTCTTTT	0.353													0	0	0	0.00499	0	18	86										T	197070599	C	T	197070599	2	4	40	1	0	0	0	0	0	0	0	1	1056	912	32	1		1	ASPM	1	197070599	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11026579	197070599	52180022	80	9753										
KDM5B	10765	broad.mit.edu	37	chr1	202718108	202718108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctcttaaagctttctcatCctcaatcataatggccatgt	4	11	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:202718108C>T	uc001gyf.2	-	14	2097	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	KDM5B_uc009xag.2_Missense_Mutation_p.D697N|KDM5B_uc001gyg.1_Missense_Mutation_p.D503N	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	661					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GCTTTCTCATCCTCAATCATA	0.388													0	0	0	0.011902	0	46	153										T	202718108	C	T	202718108	3	4	40	1	0	0	0	0	1	0	0	0	8134	855	30	1	2709	1	KDM5B	1	202718108	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5647509	202718108	46532513	81	9754										
CYB5R1	51706	broad.mit.edu	37	chr1	202935922	202935922	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tacttttcattggggtccagGagagtgacctgaggccggcg	15	9	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:202935922G>C	uc001gyt.2	-	2	191	c.120C>G	c.(118-120)CTC>CTG	p.L40L	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	40					sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			TGGGGTCCAGGAGAGTGACCT	0.632													0	0	0	0.001168	0	5	54										C	202935922	G	C	202935922	2	2	40	1	0	0	0	0	0	0	0	1	4126	1161	41	1		1	CYB5R1	1	202935922	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	217814	202935922	46314699	82	9755										
LAX1	54900	broad.mit.edu	37	chr1	203743331	203743331	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggctgtggagatgctggtgActgcaccagtttgtattctc	14	8	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:203743331A>G	uc001haa.2	+	5	1129	c.719A>G	c.(718-720)GAC>GGC	p.D240G	LAX1_uc010pql.1_Missense_Mutation_p.D224G|LAX1_uc001hab.2_Missense_Mutation_p.D164G	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	240	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GATGCTGGTGACTGCACCAGT	0.473													0	0	0	0.004656	0	24	44										G	203743331	A	G	203743331	3	3	40	1	0	0	0	0	1	0	0	0	8648	275	10	5	782	5	LAX1	1	203743331	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	807409	203743331	45507290	83	9756										
REN	5972	broad.mit.edu	37	chr1	204129688	204129688	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctagggcggcccaacttacGgtgatgatgtcctggctgag	14	11	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:204129688G>C	uc001haq.2	-	4	536	c.492C>G	c.(490-492)ACC>ACG	p.T164T		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	164					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CCCAACTTACGGTGATGATGT	0.597													0	0	0	0.001855	0	14	41										C	204129688	G	C	204129688	2	2	40	1	0	0	0	0	0	0	0	1	13224	1130	39	4		4	REN	1	204129688	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	386357	204129688	45120933	84	9757										
PFKFB2	5208	broad.mit.edu	37	chr1	207228122	207228122	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tatgaaaccaaaaccccaaaTcttcgaatgtcagagaagaa	6	9	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:207228122T>C	uc001hfg.2	+	2	169	c.60T>C	c.(58-60)AAT>AAC	p.N20N	PFKFB2_uc010psc.1_5'UTR|YOD1_uc001hff.1_5'Flank|PFKFB2_uc001hfh.2_Silent_p.N20N|PFKFB2_uc009xcc.2_5'UTR	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	20	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					AAACCCCAAATCTTCGAATGT	0.428													0	0	0	0.00308	0	7	30										C	207228122	T	C	207228122	2	2	40	1	0	0	0	0	0	0	0	1	11761	1432	50	5		5	PFKFB2	1	207228122	Silent	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	3098434	207228122	42022499	85	9758										
CD55	1604	broad.mit.edu	37	chr1	207495889	207495889	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccttaagggcagtcaatggtCagatattgaagagttctgca	11	7	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:207495889C>T	uc001hfq.3	+	2	557	c.263C>T	c.(262-264)TCA>TTA	p.S88L	CD55_uc001hfp.3_Missense_Mutation_p.S88L|CD55_uc001hfr.3_Missense_Mutation_p.S88L|CD55_uc010psf.1_RNA|CD55_uc009xcf.2_Missense_Mutation_p.S88L|CD55_uc009xce.2_Missense_Mutation_p.S88L	NM_000574	NP_000565	P08174	DAF_HUMAN	decay accelerating factor for complement isoform	88	Sushi 1.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			ovary(1)	1					Chloramphenicol(DB00446)	AGTCAATGGTCAGATATTGAA	0.363													0	0	0	0.004878	0	35	79										T	207495889	C	T	207495889	3	4	40	1	0	0	0	0	1	0	0	0	3024	838	29	1	269	1	CD55	1	207495889	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	267767	207495889	41754732	86	9759										
C1orf107	27042	broad.mit.edu	37	chr1	210010531	210010531	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggtgatgatgatgacttcaGagaccaagggttaacaaggc	14	6	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:210010531G>A	uc001hhr.1	+	6	1113	c.1037G>A	c.(1036-1038)AGA>AAA	p.R346K	C1orf107_uc009xcu.1_Missense_Mutation_p.R61K	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	346					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GATGACTTCAGAGACCAAGGG	0.522													0	0	0	0.009096	0	4	36										A	210010531	G	A	210010531	3	1	40	1	0	0	0	0	1	0	0	0	1981	942	33	1	1059	1	C1orf107	1	210010531	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2514642	210010531	39240090	87	9760										
LPGAT1	9926	broad.mit.edu	37	chr1	211966441	211966441	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttgtcctggaggcacatcatCagtgtgcacacatctcctgt	9	12	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:211966441C>T	uc001hiu.2	-	3	1143	c.330G>A	c.(328-330)CTG>CTA	p.L110L	LPGAT1_uc001hiv.2_Silent_p.L110L	NM_014873	NP_055688	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	110					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		GGCACATCATCAGTGTGCACA	0.403													0	0	0	0.01441	0	123	283										T	211966441	C	T	211966441	2	4	40	1	0	0	0	0	0	0	0	1	8914	813	29	1		1	LPGAT1	1	211966441	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1955910	211966441	37284180	88	9761										
FLVCR1	28982	broad.mit.edu	37	chr1	213032136	213032136	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcgtggtgctcctgatcttCagcctgtactcgctggtcaa	10	12	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:213032136C>T	uc001hjt.2	+	1	540	c.342C>T	c.(340-342)TTC>TTT	p.F114F	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	114	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		TCCTGATCTTCAGCCTGTACT	0.637													0	0	0	0.012319	0	22	44										T	213032136	C	T	213032136	2	4	40	1	0	0	0	0	0	0	0	1	5945	825	29	1		1	FLVCR1	1	213032136	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1065695	213032136	36218485	89	9762										
RPS6KC1	26750	broad.mit.edu	37	chr1	213415370	213415370	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgctgtttacagatcagactGatgatttggctaaagaggaa	11	5	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:213415370G>A	uc010ptr.1	+	11	2710	c.2551G>A	c.(2551-2553)GAT>AAT	p.D851N	RPS6KC1_uc001hkd.2_Missense_Mutation_p.D839N|RPS6KC1_uc010pts.1_Missense_Mutation_p.D639N|RPS6KC1_uc010ptt.1_Missense_Mutation_p.D639N|RPS6KC1_uc010ptu.1_Missense_Mutation_p.D670N|RPS6KC1_uc010ptv.1_Missense_Mutation_p.D386N|RPS6KC1_uc001hke.2_Missense_Mutation_p.D670N	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	851	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AGATCAGACTGATGATTTGGC	0.383													0	0	0	0.01441	0	64	173										A	213415370	G	A	213415370	3	1	40	1	0	0	0	0	1	0	0	0	13658	1290	45	1	2593	1	RPS6KC1	1	213415370	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	383234	213415370	35835251	90	9763										
TAF1A	9015	broad.mit.edu	37	chr1	222743964	222743964	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatgtcttccagctgtggttGaacacatcctgggctactgc	11	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:222743964G>A	uc009xdz.1	-	6	837	c.648C>T	c.(646-648)TTC>TTT	p.F216F	TAF1A_uc001hni.1_Silent_p.F102F|TAF1A_uc001hnj.2_Silent_p.F216F|TAF1A_uc001hnk.2_Silent_p.F102F|TAF1A_uc010pur.1_Silent_p.F216F	NM_139352	NP_647603	Q15573	TAF1A_HUMAN	TBP-associated factor 1A isoform 2	216					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding				0				GBM - Glioblastoma multiforme(131;0.0186)		AGCTGTGGTTGAACACATCCT	0.363													0	0	0	0.01441	0	85	166										A	222743964	G	A	222743964	2	1	40	1	0	0	0	0	0	0	0	1	15516	1281	45	1		1	TAF1A	1	222743964	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	9328594	222743964	26506657	91	9764										
OBSCN	84033	broad.mit.edu	37	chr1	228434453	228434453	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccaggcagatgctggggagTacacctgtgaggctgggggc	19	9	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:228434453T>A	uc009xez.1	+	13	4026	c.3982T>A	c.(3982-3984)TAC>AAC	p.Y1328N	OBSCN_uc001hsn.2_Missense_Mutation_p.Y1328N	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1328	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCTGGGGAGTACACCTGTGA	0.597													0	0	0	0.003755	0	31	68										A	228434453	T	A	228434453	3	1	40	1	0	0	0	0	1	0	0	0	10812	1638	57	5	4028	5	OBSCN	1	228434453	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	5690489	228434453	20816168	92	9765										
URB2	9816	broad.mit.edu	37	chr1	229771854	229771854	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcgggcccctccacggtactCtctgcatgcctcctggagct	10	17	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:229771854C>T	uc001hts.1	+	4	1630	c.1494C>T	c.(1492-1494)CTC>CTT	p.L498L	URB2_uc009xfd.1_Silent_p.L498L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	498						nucleolus				central_nervous_system(2)|ovary(1)	3						CCACGGTACTCTCTGCATGCC	0.577													0	0	0	0.01441	0	62	127										T	229771854	C	T	229771854	2	4	40	1	0	0	0	0	0	0	0	1	17022	900	32	1		1	URB2	1	229771854	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1337401	229771854	19478767	93	9766										
URB2	9816	broad.mit.edu	37	chr1	229772944	229772944	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatttgcaaaagctggacccGaaggtatagaacctagagga	12	7	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:229772944G>A	uc001hts.1	+	4	2720	c.2584G>A	c.(2584-2586)GAA>AAA	p.E862K	URB2_uc009xfd.1_Missense_Mutation_p.E862K	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	862						nucleolus				central_nervous_system(2)|ovary(1)	3						AGCTGGACCCGAAGGTATAGA	0.498													0	0	0	0.010504	0	21	144										A	229772944	G	A	229772944	3	1	40	1	0	0	0	0	1	0	0	0	17022	1059	37	1	2594	1	URB2	1	229772944	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1090	229772944	19477677	94	9767										
URB2	9816	broad.mit.edu	37	chr1	229773668	229773668	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctgtgctgcagctctgctCagtgccgggggcccggggct	17	13	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:229773668C>T	uc001hts.1	+	4	3444	c.3308C>T	c.(3307-3309)TCA>TTA	p.S1103L	URB2_uc009xfd.1_Missense_Mutation_p.S1103L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1103						nucleolus				central_nervous_system(2)|ovary(1)	3						CAGCTCTGCTCAGTGCCGGGG	0.647													0	0	0	0.010504	0	17	69										T	229773668	C	T	229773668	3	4	40	1	0	0	0	0	1	0	0	0	17022	838	29	1	3318	1	URB2	1	229773668	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	724	229773668	19476953	95	9768										
COG2	22796	broad.mit.edu	37	chr1	230819378	230819378	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagatgtcctggaagatgccCcaggtaactcccttaaagtg	10	11	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:230819378C>T	uc001htw.2	+	11	1376	c.1225C>T	c.(1225-1227)CCA>TCA	p.P409S	COG2_uc001htx.2_Missense_Mutation_p.P409S|COG2_uc010pwc.1_Missense_Mutation_p.P282S	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	409					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				GGAAGATGCCCCAGGTAACTC	0.393													0	0	0	0.013114	0	42	91										T	230819378	C	T	230819378	3	4	40	1	0	0	0	0	1	0	0	0	3658	623	22	2	1267	2	COG2	1	230819378	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1045710	230819378	18431243	96	9769										
FMN2	56776	broad.mit.edu	37	chr1	240341299	240341299	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagaagggcagtttcctaggCgagttccatccatggggcca	13	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:240341299C>T	uc010pyd.1	+	3	2086	c.1861C>T	c.(1861-1863)CGA>TGA	p.R621*	FMN2_uc010pye.1_Nonsense_Mutation_p.R621*	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	621					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTTTCCTAGGCGAGTTCCATC	0.448													0	0	0	0.007291	0	25	67										T	240341299	C	T	240341299	4	4	40	1	0	0	0	0	0	1	0	0	5950	760	27	2	1871	2	FMN2	1	240341299	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9521921	240341299	8909322	97	9770										
EXO1	9156	broad.mit.edu	37	chr1	242048771	242048771	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacaagccggggttacagatCaaactcaatgagctctggaa	10	9	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:242048771C>G	uc001hzh.2	+	15	2907	c.2367C>G	c.(2365-2367)ATC>ATG	p.I789M	EXO1_uc001hzi.2_Missense_Mutation_p.I789M|EXO1_uc001hzj.2_Missense_Mutation_p.I789M|EXO1_uc009xgq.2_Missense_Mutation_p.I788M	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	789	Interaction with MLH1.|Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GGTTACAGATCAAACTCAATG	0.428								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.00278	0	20	89										G	242048771	C	G	242048771	3	3	40	1	0	0	0	0	1	0	0	0	5300	816	29	1	2413	1	EXO1	1	242048771	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1707472	242048771	7201850	98	9771										
ADSS	159	broad.mit.edu	37	chr1	244614999	244614999	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caccaccttccctttgccttCgtcgccccactgcgcaccga	6	21	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:244614999C>T	uc001iaj.2	-	1	415	c.121G>A	c.(121-123)GAA>AAA	p.E41K	C1orf101_uc001iak.1_5'Flank|ADSS_uc009xgr.1_RNA	NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	41	IMP binding (By similarity).|GTP.				AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CCTTTGCCTTCGTCGCCCCAC	0.736													0	0	0	0.000602	0	4	9										T	244614999	C	T	244614999	3	4	40	1	0	0	0	0	1	0	0	0	347	893	31	1	1301	1	ADSS	1	244614999	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2566228	244614999	4635622	99	9772										
OR2G2	81470	broad.mit.edu	37	chr1	247752506	247752506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtttgtttctctcttctacaCtgtggtaacccgcatgctta	7	11	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr1:247752506C>T	uc010pyy.1	+	1	845	c.845C>T	c.(844-846)ACT>ATT	p.T282I		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCTTCTACACTGTGGTAACC	0.348													0	0	0	0.01441	0	125	201										T	247752506	C	T	247752506	3	4	40	1	0	0	0	0	1	0	0	0	10998	565	20	2	847	2	OR2G2	1	247752506	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3137507	247752506	1498115	100	9773										
GREB1	9687	broad.mit.edu	37	chr2	11765299	11765299	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacctcagagaagaatctgaCtggcattatctccagcttag	9	10	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:11765299C>T	uc002rbk.1	+	24	4467	c.4167C>T	c.(4165-4167)GAC>GAT	p.D1389D	GREB1_uc002rbp.1_Silent_p.D387D	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1389						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		AAGAATCTGACTGGCATTATC	0.378													0	0	0	0.00623	0	41	263										T	11765299	C	T	11765299	2	4	40	1	0	0	0	0	0	0	0	1	6760	564	20	2		2	GREB1	2	11765299	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		11765299	231434074	101	9774										
GREB1	9687	broad.mit.edu	37	chr2	11774306	11774306	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctttgaagcacatcatgcagCacatcgaggcggcccccgac	10	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:11774306C>T	uc002rbk.1	+	29	5341	c.5041C>T	c.(5041-5043)CAC>TAC	p.H1681Y	GREB1_uc002rbp.1_Missense_Mutation_p.H679Y	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1681						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CATCATGCAGCACATCGAGGC	0.622													0	0	0	0.006122	0	17	111										T	11774306	C	T	11774306	3	4	40	1	0	0	0	0	1	0	0	0	6760	710	25	2	5259	2	GREB1	2	11774306	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9007	11774306	231425067	102	9775										
RAD51AP2	729475	broad.mit.edu	37	chr2	17699508	17699508	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcccagactttttccgcctCagacaagcgaggcaccagag	9	15	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:17699508C>T	uc002rcl.1	-	1	199	c.175G>A	c.(175-177)GAG>AAG	p.E59K	RAD51AP2_uc010exn.1_Missense_Mutation_p.E50K	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	59										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTTCCGCCTCAGACAAGCGA	0.547													0	0	0	0.006999	0	40	124										T	17699508	C	T	17699508	3	4	40	1	0	0	0	0	1	0	0	0	12987	835	29	1	3316	1	RAD51AP2	2	17699508	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5925202	17699508	225499865	103	9776										
VSNL1	7447	broad.mit.edu	37	chr2	17773477	17773477	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caagtgggaggctaaatctcGaggaatttcagcagctctat	11	8	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:17773477G>C	uc002rcm.2	+	2	520	c.136G>C	c.(136-138)GAG>CAG	p.E46Q		NM_003385	NP_003376	P62760	VISL1_HUMAN	visinin-like 1	46	EF-hand 1.						calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GCTAAATCTCGAGGAATTTCA	0.428													0	0	0	0.012213	0	30	209										C	17773477	G	C	17773477	3	2	40	1	0	0	0	0	1	0	0	0	17224	1059	37	1	138	1	VSNL1	2	17773477	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	73969	17773477	225425896	104	9777										
PUM2	23369	broad.mit.edu	37	chr2	20451400	20451400	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctaggtccgggctattcttCaaataatacttttccaactt	5	11	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:20451400C>T	uc002rds.1	-	20	3164	c.3141G>A	c.(3139-3141)TTG>TTA	p.L1047L	PUM2_uc002rdq.1_Silent_p.L426L|PUM2_uc002rdt.1_Silent_p.L1047L|PUM2_uc002rdr.2_Silent_p.L907L|PUM2_uc010yjy.1_Silent_p.L968L|PUM2_uc002rdu.1_Silent_p.L1047L|PUM2_uc010yjz.1_Silent_p.L986L	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	1049					regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTATTCTTCAAATAATACT	0.378													0	0	0	0.01441	0	84	219										T	20451400	C	T	20451400	2	4	40	1	0	0	0	0	0	0	0	1	12826	825	29	1		1	PUM2	2	20451400	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2677923	20451400	222747973	105	9778										
KIF3C	3797	broad.mit.edu	37	chr2	26204414	26204414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatgtgggtgaagatgtgctCaaaggcattcgggatgaccc	15	7	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:26204414C>T	uc002rgu.2	-	1	1030	c.373G>A	c.(373-375)GAG>AAG	p.E125K	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.E125K	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	125	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGATGTGCTCAAAGGCATTC	0.592													0	0	0	0.006122	0	19	114										T	26204414	C	T	26204414	3	4	40	1	0	0	0	0	1	0	0	0	8302	835	29	1	2040	1	KIF3C	2	26204414	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5753014	26204414	216994959	106	9779										
GTF3C2	2976	broad.mit.edu	37	chr2	27566319	27566319	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctgaagaggtcttgacatCaagctgatttagcacctctt	8	9	4	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:27566319C>T	uc002rjv.1	-	3	466	c.103G>A	c.(103-105)GAT>AAT	p.D35N	GTF3C2_uc002rju.1_Missense_Mutation_p.D46N|GTF3C2_uc002rjw.1_Missense_Mutation_p.D35N|GTF3C2_uc010eyz.1_Missense_Mutation_p.D35N	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	35						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCTTGACATCAAGCTGATTT	0.547													0	0	0	0.01441	0	82	199										T	27566319	C	T	27566319	3	4	40	1	0	0	0	0	1	0	0	0	6873	826	29	1	2704	1	GTF3C2	2	27566319	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1361905	27566319	215633054	107	9780										
ZNF513	130557	broad.mit.edu	37	chr2	27603057	27603058	+	Frame_Shift_Del	DEL	CA	CA	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccagatcctggcctagtagCaaatcactctccaataccag							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:27603057_27603058delCA	uc002rkk.2	-	2	313_314	c.113_114delTG	c.(112-114)TTGfs	p.L38fs	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	38					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCTAGTAGCAAATCACTCTC	0.574																		47	153	---	---								-	27603058	CA	-	27603057	7	5	40	1	0	1	0	1	0	0	0	0	17955	709	25	0	1523	0	ZNF513	2	27603057	Frame_Shift_Del	DEL	CA	TCGA-DK-A1A3-01A-11D-A13W-08	36738	27603057	215596316	108	9781										
PPM1G	5496	broad.mit.edu	37	chr2	27609992	27609992	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacagaaaacatggctgtctCactgtccagctcaggaatac	9	11	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:27609992C>T	uc002rkl.2	-	3	261	c.154G>A	c.(154-156)GAG>AAG	p.E52K	PPM1G_uc002rkm.2_5'UTR	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	52					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATGGCTGTCTCACTGTCCAGC	0.448													0	0	0	0.005524	0	31	56										T	27609992	C	T	27609992	3	4	40	1	0	0	0	0	1	0	0	0	12340	835	29	1	1522	1	PPM1G	2	27609992	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6935	27609992	215589381	109	9782										
XDH	7498	broad.mit.edu	37	chr2	31572632	31572632	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcccagcatctgggcaaggtGaaaccctcaagcttctggtt	10	12	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:31572632G>A	uc002rnv.1	-	26	2968	c.2889C>T	c.(2887-2889)TTC>TTT	p.F963F		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	963					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TGGGCAAGGTGAAACCCTCAA	0.498													0	0	0	0.01441	0	52	202										A	31572632	G	A	31572632	2	1	40	1	0	0	0	0	0	0	0	1	17423	1281	45	1		1	XDH	2	31572632	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3962640	31572632	211626741	110	9783										
SPAST	6683	broad.mit.edu	37	chr2	32289086	32289086	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgctgtttgtaggcttcgcGctgctgcgtttggtcgcctt	13	12	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:32289086G>C	uc002roc.2	+	1	407	c.186G>C	c.(184-186)GCG>GCC	p.A62A	SPAST_uc002rod.2_Silent_p.A62A	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	62	Required for interaction with SSNA1 and microtubules.|Required for interaction with RTN1.|Nuclear export signal.|Required for interaction with ATL1.|Helical; (Potential).|Required for midbody localization.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TAGGCTTCGCGCTGCTGCGTT	0.502													0	0	0	0.00308	0	7	15										C	32289086	G	C	32289086	2	2	40	1	0	0	0	0	0	0	0	1	14996	1074	38	4		4	SPAST	2	32289086	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	716454	32289086	210910287	111	9784										
SLC30A6	55676	broad.mit.edu	37	chr2	32419049	32419049	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaccttttgcttatgtctcaGaaggtatgttttttatttac	6	6	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:32419049G>A	uc002roe.1	+	8	530	c.493G>A	c.(493-495)GAA>AAA	p.E165K	SLC30A6_uc002rof.1_Missense_Mutation_p.E205K|SLC30A6_uc010ymw.1_Missense_Mutation_p.E136K|SLC30A6_uc010ezr.1_Missense_Mutation_p.E165K|SLC30A6_uc002rog.1_5'UTR|SLC30A6_uc010ezs.1_Missense_Mutation_p.E91K|SLC30A6_uc002roh.1_5'UTR	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	165	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTATGTCTCAGAAGGTATGTT	0.313													0	0	0	0.004656	0	27	187										A	32419049	G	A	32419049	3	1	40	1	0	0	0	0	1	0	0	0	14559	943	33	1	523	1	SLC30A6	2	32419049	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	129963	32419049	210780324	112	9785										
BIRC6	57448	broad.mit.edu	37	chr2	32740283	32740283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taacagatgactctaaaaatGcacaagcacctctcgcatta	5	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:32740283G>A	uc010ezu.2	+	55	10929	c.10795G>A	c.(10795-10797)GCA>ACA	p.A3599T		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3599					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCTAAAAATGCACAAGCACC	0.408													0	0	0	0.013537	0	12	104										A	32740283	G	A	32740283	3	1	40	1	0	0	0	0	1	0	0	0	1438	1319	46	2	11013	2	BIRC6	2	32740283	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	321234	32740283	210459090	113	9786										
RASGRP3	25780	broad.mit.edu	37	chr2	33745672	33745672	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atttggatcttggtttgattCgtatgactgaggaatttcgg	12	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:33745672C>A	uc002rox.2	+	7	916	c.289C>A	c.(289-291)CGT>AGT	p.R97S	RASGRP3_uc010ync.1_Missense_Mutation_p.R97S|RASGRP3_uc002roy.2_Missense_Mutation_p.R97S	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	97	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					TGGTTTGATTCGTATGACTGA	0.423													1	0	5.10652e-33	0.01441	5.4203e-33	65	333										A	33745672	C	A	33745672	3	1	40	1	0	0	0	0	1	0	0	0	13076	884	31	3	303	3	RASGRP3	2	33745672	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1005389	33745672	209453701	114	9787										
GALM	130589	broad.mit.edu	37	chr2	38893363	38893363	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcgggaggagggacagtggaGaagttccagctgcagtcaga	17	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:38893363G>A	uc002rqy.2	+	1	312	c.60G>A	c.(58-60)GAG>GAA	p.E20E		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	20					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				GGACAGTGGAGAAGTTCCAGC	0.597													0	0	0	0.003163	0	16	45										A	38893363	G	A	38893363	2	1	40	1	0	0	0	0	0	0	0	1	6205	933	33	1		1	GALM	2	38893363	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5147691	38893363	204306010	115	9788										
DHX57	90957	broad.mit.edu	37	chr2	39042771	39042771	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atatccgataacagttccgtGaattgtcgtttgaggctggc	11	8	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:39042771G>A	uc002rrf.2	-	20	3597	c.3498C>T	c.(3496-3498)TTC>TTT	p.F1166F	DHX57_uc002rrd.3_Silent_p.F550F|DHX57_uc002rre.2_Silent_p.F599F	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1166							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				ACAGTTCCGTGAATTGTCGTT	0.443													0	0	0	0.01441	0	46	116										A	39042771	G	A	39042771	2	1	40	1	0	0	0	0	0	0	0	1	4513	1281	45	1		1	DHX57	2	39042771	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	149408	39042771	204156602	116	9789										
THADA	63892	broad.mit.edu	37	chr2	43458299	43458299	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggaagctctctgaagaactGagacaggaggtggcactgct	14	8	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:43458299G>A	uc002rsw.3	-	38	6002	c.5650C>T	c.(5650-5652)CAG>TAG	p.Q1884*	THADA_uc010far.2_Nonsense_Mutation_p.Q1079*|THADA_uc002rsx.3_Nonsense_Mutation_p.Q1884*|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1884							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CTGAAGAACTGAGACAGGAGG	0.532													0	0	0	0.013537	0	12	28										A	43458299	G	A	43458299	4	1	40	1	0	0	0	0	0	1	0	0	15837	1299	45	1	215	1	THADA	2	43458299	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4415528	43458299	199741074	117	9790										
TTC7A	57217	broad.mit.edu	37	chr2	47249004	47249004	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtctctcctctttgcagctaGaggaagcagagcactttgcc	10	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:47249004G>A	uc002rvo.2	+	12	1764	c.1396G>A	c.(1396-1398)GAG>AAG	p.E466K	TTC7A_uc002rvm.2_Missense_Mutation_p.E432K|TTC7A_uc002rvn.1_Missense_Mutation_p.E347K|TTC7A_uc010fbb.2_Missense_Mutation_p.E466K|TTC7A_uc010fbc.2_Missense_Mutation_p.E112K|TTC7A_uc002rvp.2_Missense_Mutation_p.E347K|TTC7A_uc002rvq.2_Missense_Mutation_p.E206K|TTC7A_uc002rvr.2_Intron	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	466							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTTGCAGCTAGAGGAAGCAGA	0.562													0	0	0	0.004878	0	38	99										A	47249004	G	A	47249004	3	1	40	1	0	0	0	0	1	0	0	0	16709	943	33	1	1442	1	TTC7A	2	47249004	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3790705	47249004	195950369	118	9791										
XPO1	7514	broad.mit.edu	37	chr2	61710158	61710158	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatatcacaaaaataagtttGataaaaactctgagctgcag	6	6	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:61710158G>C	uc002sbj.2	-	22	3474	c.2746C>G	c.(2746-2748)CAA>GAA	p.Q916E	XPO1_uc010fcl.2_Missense_Mutation_p.Q912E|XPO1_uc010ypn.1_Missense_Mutation_p.Q912E|XPO1_uc002sbk.2_Missense_Mutation_p.Q477E|XPO1_uc002sbg.2_Missense_Mutation_p.Q113E|XPO1_uc002sbh.2_Missense_Mutation_p.Q563E	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	916	HEAT 8.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			AAATAAGTTTGATAAAAACTC	0.333													0	0	0	0.005524	0	39	97										C	61710158	G	C	61710158	3	2	40	1	0	0	0	0	1	0	0	0	17442	1299	45	1	485	1	XPO1	2	61710158	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	14461154	61710158	181489215	119	9792										
PELI1	57162	broad.mit.edu	37	chr2	64335432	64335432	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agatggatgattttcttgatCaggagaaaacatgagcttgg	12	4	2	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:64335432C>T	uc002scs.3	-	1	4052	c.13G>A	c.(13-15)GAT>AAT	p.D5N	PELI1_uc002sct.3_Missense_Mutation_p.D5N|PELI1_uc002scu.1_5'Flank	NM_020651	NP_065702	Q96FA3	PELI1_HUMAN	pellino protein	5					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1						TTTTCTTGATCAGGAGAAAAC	0.383													0	0	0	0.01441	0	72	177										T	64335432	C	T	64335432	3	4	40	1	0	0	0	0	1	0	0	0	11721	826	29	1	1267	1	PELI1	2	64335432	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2625274	64335432	178863941	120	9793										
NAGK	55577	broad.mit.edu	37	chr2	71298938	71298938	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accgatgccgccggctccatCgccacagctacaccggatgg	11	17	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:71298938C>T	uc002shp.3	+	4	742	c.336C>T	c.(334-336)ATC>ATT	p.I112I	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_5'UTR|NAGK_uc002shr.2_Silent_p.I61I	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	112					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	CCGGCTCCATCGCCACAGCTA	0.547													0	0	0	0.009096	0	3	42										T	71298938	C	T	71298938	2	4	40	1	0	0	0	0	0	0	0	1	10142	874	31	1		1	NAGK	2	71298938	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6963506	71298938	171900435	121	9794										
CCDC142	84865	broad.mit.edu	37	chr2	74708006	74708006	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcttctgcctcatgcaacaGaggctttgggtggaaacagg	13	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:74708006G>A	uc002slr.2	-	5	1786	c.1393C>T	c.(1393-1395)CTG>TTG	p.L465L	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Silent_p.L458L|CCDC142_uc002slp.2_Silent_p.L465L	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	465										central_nervous_system(1)	1						TCATGCAACAGAGGCTTTGGG	0.572													0	0	0	0.00623	0	39	100										A	74708006	G	A	74708006	2	1	40	1	0	0	0	0	0	0	0	1	2776	933	33	1		1	CCDC142	2	74708006	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3409068	74708006	168491367	122	9795										
LRRTM1	347730	broad.mit.edu	37	chr2	80529640	80529640	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acgatgaggaaggagaagatGagggccatggtgcccgtgac	17	7	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:80529640G>A	uc002sok.1	-	2	1575	c.1305C>T	c.(1303-1305)CTC>CTT	p.L435L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	435	Helical; (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AGGAGAAGATGAGGGCCATGG	0.622										HNSCC(69;0.2)			0	0	0	0.010504	0	20	45										A	80529640	G	A	80529640	2	1	40	1	0	0	0	0	0	0	0	1	9039	1277	45	1		1	LRRTM1	2	80529640	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5821634	80529640	162669733	123	9796										
C2orf89	129293	broad.mit.edu	37	chr2	85097505	85097505	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acttcagtcagggagttgacCatgagcatcacccagacagg	11	11	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:85097505C>T	uc010ysl.1	-	2	602	c.513G>A	c.(511-513)ATG>ATA	p.M171I	C2orf89_uc002sou.3_Missense_Mutation_p.M171I|C2orf89_uc010fgc.1_Missense_Mutation_p.M171I	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	171	Extracellular (Potential).					integral to membrane				ovary(1)	1						GGGAGTTGACCATGAGCATCA	0.582													0	0	0	0.01441	0	54	135										T	85097505	C	T	85097505	3	4	40	1	0	0	0	0	1	0	0	0	2203	594	21	2	877	2	C2orf89	2	85097505	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4567865	85097505	158101868	124	9797										
GGCX	2677	broad.mit.edu	37	chr2	85777223	85777223	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacggcctaatatcagatttCgaagtgagatacaagtcatc	9	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:85777223C>T	uc002sps.2	-	15	2217	c.2111G>A	c.(2110-2112)CGA>CAA	p.R704Q	GGCX_uc010yss.1_Missense_Mutation_p.R520Q|GGCX_uc010yst.1_Missense_Mutation_p.R647Q	NM_000821	NP_000812	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase isoform 1	704	Lumenal (Potential).				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	TATCAGATTTCGAAGTGAGAT	0.463													0	0	0	0.003954	0	21	77										T	85777223	C	T	85777223	3	4	40	1	0	0	0	0	1	0	0	0	6356	884	31	1	169	1	GGCX	2	85777223	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	679718	85777223	157422150	125	9798										
USP39	10713	broad.mit.edu	37	chr2	85857963	85857963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagcgttttggagagctgatGagaaagctctggaaccctcg	13	9	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:85857963G>A	uc002sqe.2	+	6	879	c.843G>A	c.(841-843)ATG>ATA	p.M281I	USP39_uc002sqb.2_Missense_Mutation_p.M12I|USP39_uc010ysu.1_Missense_Mutation_p.M203I|USP39_uc010ysv.1_Missense_Mutation_p.M178I|USP39_uc010fgn.1_Missense_Mutation_p.M281I|USP39_uc002sqf.2_Missense_Mutation_p.M281I|USP39_uc002sqg.2_Missense_Mutation_p.M281I|USP39_uc010fgo.2_Missense_Mutation_p.M281I	NM_006590	NP_006581	Q53GS9	SNUT2_HUMAN	ubiquitin specific protease 39	281					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1						GAGAGCTGATGAGAAAGCTCT	0.448													0	0	0	0.01441	0	89	216										A	85857963	G	A	85857963	3	1	40	1	0	0	0	0	1	0	0	0	17067	1290	45	1	865	1	USP39	2	85857963	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	80740	85857963	157341410	126	9799										
CD8A	925	broad.mit.edu	37	chr2	87017667	87017667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaggtgggactggcggcggCgccgcgcggctggaagagcc	21	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:87017667C>T	uc002srt.2	-	2	1076	c.187G>A	c.(187-189)GCC>ACC	p.A63T	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.A63T|CD8A_uc010ytn.1_Missense_Mutation_p.A104T|CD8A_uc002sru.2_Missense_Mutation_p.A63T	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	63	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						CTGGCGGCGGCGCCGCGCGGC	0.672													0	0	0	0.014323	0	23	36										T	87017667	C	T	87017667	3	4	40	1	0	0	0	0	1	0	0	0	3044	768	27	2	540	2	CD8A	2	87017667	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1159704	87017667	156181706	127	9800										
ZNF514	84874	broad.mit.edu	37	chr2	95815496	95815496	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttgatgtttaataagggatGaaatatgaccaaaggctctt	9	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:95815496G>A	uc002sue.1	-	5	1108	c.734C>T	c.(733-735)TCA>TTA	p.S245L	ZNF514_uc002sud.1_Missense_Mutation_p.S318L	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	245	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATAAGGGATGAAATATGACC	0.458													0	0	0	0.01441	0	78	172										A	95815496	G	A	95815496	3	1	40	1	0	0	0	0	1	0	0	0	17956	1294	45	1	472	1	ZNF514	2	95815496	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	8797829	95815496	147383877	128	9801										
ITPRIPL1	150771	broad.mit.edu	37	chr2	96992597	96992597	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagaaggcagagaacttctgGacaggagacacatccagtga	12	9	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:96992597G>A	uc002svx.2	+	3	563	c.228G>A	c.(226-228)TGG>TGA	p.W76*	ITPRIPL1_uc010yuk.1_Nonsense_Mutation_p.W68*|ITPRIPL1_uc002svy.2_Nonsense_Mutation_p.W84*|ITPRIPL1_uc010yul.1_Nonsense_Mutation_p.W68*	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	76	Extracellular (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						AGAACTTCTGGACAGGAGACA	0.577													0	0	0	0.012213	0	32	77										A	96992597	G	A	96992597	4	1	40	1	0	0	0	0	0	1	0	0	7924	1183	41	1	268	1	ITPRIPL1	2	96992597	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1177101	96992597	146206776	129	9802										
ARID5A	10865	broad.mit.edu	37	chr2	97217382	97217382	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttaaagatggggtgctattgGggcctcctggcaaagagggg	17	6	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:97217382G>C	uc002swe.2	+	7	1217	c.1117G>C	c.(1117-1119)GGG>CGG	p.G373R	ARID5A_uc010yuq.1_Missense_Mutation_p.G321R|ARID5A_uc002swf.2_Missense_Mutation_p.G209R|ARID5A_uc002swg.2_Missense_Mutation_p.G321R	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	373					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						GGTGCTATTGGGGCCTCCTGG	0.587													0	0	0	0.004482	0	8	22										C	97217382	G	C	97217382	3	2	40	1	0	0	0	0	1	0	0	0	921	1232	43	4	1143	4	ARID5A	2	97217382	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	224785	97217382	145981991	130	9803										
FER1L5	90342	broad.mit.edu	37	chr2	97365766	97365766	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccgcctctgttcagtcctGaggaagatgctgttttctat	9	11	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:97365766G>A	uc010fia.2	+	43	4960	c.4960G>A	c.(4960-4962)GAG>AAG	p.E1654K	FER1L5_uc002sws.3_Missense_Mutation_p.E372K|FER1L5_uc002swt.3_Missense_Mutation_p.E372K|FER1L5_uc010yus.1_Missense_Mutation_p.E371K	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1654						integral to membrane				ovary(1)	1						GTTCAGTCCTGAGGAAGATGC	0.527													0	0	0	0.007291	0	26	50										A	97365766	G	A	97365766	3	1	40	1	0	0	0	0	1	0	0	0	5814	1291	45	1	5130	1	FER1L5	2	97365766	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	148384	97365766	145833607	131	9804										
COX5B	1329	broad.mit.edu	37	chr2	98263594	98263594	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagatcatgctggctgcaaaGaagggactggtaaggagaaa	15	5	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:98263594G>A	uc002sya.2	+	2	197	c.168G>A	c.(166-168)AAG>AAA	p.K56K		NM_001862	NP_001853	P10606	COX5B_HUMAN	cytochrome c oxidase subunit Vb precursor	56					respiratory electron transport chain|respiratory gaseous exchange	mitochondrial inner membrane	cytochrome-c oxidase activity|metal ion binding				0						TGGCTGCAAAGAAGGGACTGG	0.483													0	0	0	0.004656	0	26	73										A	98263594	G	A	98263594	2	1	40	1	0	0	0	0	0	0	0	1	3773	933	33	1		1	COX5B	2	98263594	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	897828	98263594	144935779	132	9805										
RPL31	6160	broad.mit.edu	37	chr2	101622467	101622467	+	Missense_Mutation	SNP	G	G	A													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggctgtccagaaaacgtaatGaggatgaagattcaccaaat					rs11551487		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:101622467G>A	uc002taq.3	+	4	367	c.280G>A	c.(280-282)GAG>AAG	p.E94K	RPL31_uc002tar.3_Missense_Mutation_p.E94K|RPL31_uc010yvu.1_Missense_Mutation_p.E94K|RPL31_uc010yvv.1_Missense_Mutation_p.E94K|RPL31_uc010fiu.1_Missense_Mutation_p.E94K|RPL31_uc002tas.1_Missense_Mutation_p.E94K|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	94					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						AAAACGTAATGAGGATGAAGA	0.388													0	0	0	0.003163	0	7	68										A	101622467	G	A	101622467	3	1	40	1	0	0	0	0	1	0	0	0	13581	1291	45	1	290	1	RPL31	2	101622467	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3358873	101622467	141576906	133	9806	49	3								
RPL31	6160	broad.mit.edu	37	chr2	101622473	101622473	+	Missense_Mutation	SNP	G	G	A													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccagaaaacgtaatgaggatGaagattcaccaaataagcta							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:101622473G>A	uc002taq.3	+	4	373	c.286G>A	c.(286-288)GAA>AAA	p.E96K	RPL31_uc002tar.3_Missense_Mutation_p.E96K|RPL31_uc010yvu.1_Missense_Mutation_p.E96K|RPL31_uc010yvv.1_Missense_Mutation_p.E96K|RPL31_uc010fiu.1_Missense_Mutation_p.E96K|RPL31_uc002tas.1_Missense_Mutation_p.E96K|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	96					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TAATGAGGATGAAGATTCACC	0.378													0	0	0	0.001855	0	5	67										A	101622473	G	A	101622473	3	1	40	1	0	0	0	0	1	0	0	0	13581	1291	45	1	296	1	RPL31	2	101622473	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6	101622473	141576900	134	9807	49	3								
RPL31	6160	broad.mit.edu	37	chr2	101622476	101622476	+	Missense_Mutation	SNP	G	G	A													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaaacgtaatgaggatgaaGattcaccaaataagctatat							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:101622476G>A	uc002taq.3	+	4	376	c.289G>A	c.(289-291)GAT>AAT	p.D97N	RPL31_uc002tar.3_Missense_Mutation_p.D97N|RPL31_uc010yvu.1_Missense_Mutation_p.D97N|RPL31_uc010yvv.1_Missense_Mutation_p.D97N|RPL31_uc010fiu.1_Missense_Mutation_p.D97N|RPL31_uc002tas.1_Missense_Mutation_p.D97N|RPL31_uc002tat.1_3'UTR	NM_000993	NP_000984	P62899	RL31_HUMAN	ribosomal protein L31 isoform 1	97					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TGAGGATGAAGATTCACCAAA	0.368													0	0	0	0.010729	0	5	70										A	101622476	G	A	101622476	3	1	40	1	0	0	0	0	1	0	0	0	13581	942	33	1	299	1	RPL31	2	101622476	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3	101622476	141576897	135	9808	49	3								
IL18RAP	8807	broad.mit.edu	37	chr2	103068411	103068411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccaagagccagagtctctaCctcatctcgtgaaaaaagct	7	12	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:103068411C>T	uc002tbx.2	+	12	2054	c.1570C>T	c.(1570-1572)CCT>TCT	p.P524S	IL18RAP_uc010fiz.2_Missense_Mutation_p.P382S	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	524	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AGAGTCTCTACCTCATCTCGT	0.418													0	0	0	0.01441	0	81	174										T	103068411	C	T	103068411	3	4	40	1	0	0	0	0	1	0	0	0	7648	507	18	2	1608	2	IL18RAP	2	103068411	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1445935	103068411	140130962	136	9809										
IL18RAP	8807	broad.mit.edu	37	chr2	103068499	103068499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcccaattctaggttctgggCcaaaatgcgctaccacatgc	8	13	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:103068499C>A	uc002tbx.2	+	12	2142	c.1658C>A	c.(1657-1659)GCC>GAC	p.A553D	IL18RAP_uc010fiz.2_Missense_Mutation_p.A411D	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	553	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AGGTTCTGGGCCAAAATGCGC	0.463													1	0	5.72124e-26	0.01441	6.04366e-26	77	171										A	103068499	C	A	103068499	3	1	40	1	0	0	0	0	1	0	0	0	7648	739	26	4	1696	4	IL18RAP	2	103068499	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	88	103068499	140130874	137	9810										
SLC9A2	6549	broad.mit.edu	37	chr2	103236427	103236427	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagaccttgctgaacgcgccGagggccatgggcaccagttc	14	13	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:103236427G>A	uc002tca.2	+	1	262	c.120G>A	c.(118-120)CCG>CCA	p.P40P		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	40	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						TGAACGCGCCGAGGGCCATGG	0.448													0	0	0	0.009096	0	4	15										A	103236427	G	A	103236427	2	1	40	1	0	0	0	0	0	0	0	1	14712	1045	37	1		1	SLC9A2	2	103236427	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	167928	103236427	139962946	138	9811										
GCC2	9648	broad.mit.edu	37	chr2	109111783	109111783	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acaatctttgaagaaccttcGagaaaggagaaacacagacc	8	9	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:109111783G>C	uc002tec.2	+	20	4638	c.4484G>C	c.(4483-4485)CGA>CCA	p.R1495P	GCC2_uc002ted.2_Missense_Mutation_p.R1394P	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1495	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAGAACCTTCGAGAAAGGAGA	0.433													0	0	0	0.003163	0	15	50										C	109111783	G	C	109111783	3	2	40	1	0	0	0	0	1	0	0	0	6286	1058	37	1	4562	1	GCC2	2	109111783	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5875356	109111783	134087590	139	9812										
RANBP2	5903	broad.mit.edu	37	chr2	109398587	109398587	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcatctcctattataggtaGaagtaaaatctggagaagaa	8	5	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:109398587G>A	uc002tem.3	+	27	8890	c.8764G>A	c.(8764-8766)GAA>AAA	p.E2922K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2922	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATTATAGGTAGAAGTAAAATC	0.353													0	0	0	0.013537	0	12	88										A	109398587	G	A	109398587	3	1	40	1	0	0	0	0	1	0	0	0	13028	943	33	1	8870	1	RANBP2	2	109398587	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	286804	109398587	133800786	140	9813										
ACOXL	55289	broad.mit.edu	37	chr2	111691109	111691109	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggatgtcttccagggaaagGagctggtcaacagtcgctcg	14	9	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:111691109G>A	uc002tgr.3	+	12	1173	c.949G>A	c.(949-951)GAG>AAG	p.E317K	ACOXL_uc010fkc.2_Missense_Mutation_p.E317K|ACOXL_uc010yxk.1_Missense_Mutation_p.E317K	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	317					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						CCAGGGAAAGGAGCTGGTCAA	0.612													0	0	0	0.001984	0	7	56										A	111691109	G	A	111691109	3	1	40	1	0	0	0	0	1	0	0	0	161	1175	41	1	991	1	ACOXL	2	111691109	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2292522	111691109	131508264	141	9814										
ANAPC1	64682	broad.mit.edu	37	chr2	112592358	112592358	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatcctcatccttcatctgtGaagcttctgaaggactcaga	7	11	5	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:112592358G>A	uc002thi.2	-	19	2454	c.2207C>T	c.(2206-2208)TCA>TTA	p.S736L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	736					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						CTTCATCTGTGAAGCTTCTGA	0.383													0	0	0	0.004007	0	16	70										A	112592358	G	A	112592358	3	1	40	1	0	0	0	0	1	0	0	0	598	1294	45	1	3747	1	ANAPC1	2	112592358	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	901249	112592358	130607015	142	9815										
MERTK	10461	broad.mit.edu	37	chr2	112733015	112733015	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaataggctggtctgcagtGagcccttggattctagccag	13	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:112733015G>A	uc002thk.1	+	7	1232	c.1110G>A	c.(1108-1110)GTG>GTA	p.V370V	MERTK_uc002thl.1_Silent_p.V194V	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	370	Fibronectin type-III 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GGTCTGCAGTGAGCCCTTGGA	0.483													0	0	0	0.013114	0	43	97										A	112733015	G	A	112733015	2	1	40	1	0	0	0	0	0	0	0	1	9479	1277	45	1		1	MERTK	2	112733015	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	140657	112733015	130466358	143	9816										
MERTK	10461	broad.mit.edu	37	chr2	112779055	112779055	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggcctctctaagaagatttAcagtggcgattattaccgcc	9	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:112779055A>G	uc002thk.1	+	17	2368	c.2246A>G	c.(2245-2247)TAC>TGC	p.Y749C	MERTK_uc002thl.1_Missense_Mutation_p.Y573C	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	749	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						AAGAAGATTTACAGTGGCGAT	0.483													0	0	0	0.011902	0	42	122										G	112779055	A	G	112779055	3	3	40	1	0	0	0	0	1	0	0	0	9479	391	14	5	2312	5	MERTK	2	112779055	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	46040	112779055	130420318	144	9817										
SLC20A1	6574	broad.mit.edu	37	chr2	113417182	113417183	+	Missense_Mutation	DNP	GT	GT	TC													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	catctgagatagacatgagtGtcaaggcagagatgggtcta							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:113417182_113417183GT>TC	uc002tib.2	+	8	1896_1897	c.1450_1451GT>TC	c.(1450-1452)GTC>TCC	p.V484S	SLC20A1_uc002tic.1_Missense_Mutation_p.V296S	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	484	Cytoplasmic (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						AGACATGAGTGTCAAGGCAGAG	0.465													0	0	0	0.004672	0	89	221										TC	113417183	GT	TC	113417182	3	4	40	1	0	0	0	0	1	0	0	0	14438	1377	48	4	1476	4	SLC20A1	2	113417182	Missense_Mutation	DNP	GT	TCGA-DK-A1A3-01A-11D-A13W-08	638127	113417182	129782191	145	9818										
PSD4	23550	broad.mit.edu	37	chr2	113941019	113941019	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcccatctataaaccacactCcatctgctgggcctcagtgg	8	15	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:113941019C>G	uc002tjc.2	+	2	1169	c.986C>G	c.(985-987)TCC>TGC	p.S329C	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.S328C|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	329					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						AAACCACACTCCATCTGCTGG	0.617													0	0	0	0.001984	0	6	44										G	113941019	C	G	113941019	3	3	40	1	0	0	0	0	1	0	0	0	12649	855	30	1	988	1	PSD4	2	113941019	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	523837	113941019	129258354	146	9819										
PCDP1	200373	broad.mit.edu	37	chr2	120413990	120413990	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggccggagagaagctgctcGaggagatgaggaacctgcgg	18	8	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:120413990G>A	uc002tmb.2	+	25	2701	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	823						cilium	calmodulin binding				0	Colorectal(110;0.196)					GAAGCTGCTCGAGGAGATGAG	0.473													0	0	0	0.004482	0	7	40										A	120413990	G	A	120413990	3	1	40	1	0	0	0	0	1	0	0	0	11572	1059	37	1	1671	1	PCDP1	2	120413990	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6472971	120413990	122785383	147	9820										
PTPN4	5775	broad.mit.edu	37	chr2	120709702	120709702	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcatgcttctagttcgacctAatggtgagtactctatgtag	9	8	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:120709702A>T	uc002tmf.1	+	19	2581	c.1810A>T	c.(1810-1812)AAT>TAT	p.N604Y	PTPN4_uc010flj.1_Missense_Mutation_p.N317Y|PTPN4_uc010yyr.1_Missense_Mutation_p.N237Y	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	604						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGTTCGACCTAATGGTGAGTA	0.284													0	0	0	0.006122	0	19	142										T	120709702	A	T	120709702	3	4	40	1	0	0	0	0	1	0	0	0	12790	362	13	5	1880	5	PTPN4	2	120709702	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	295712	120709702	122489671	148	9821										
GPR17	2840	broad.mit.edu	37	chr2	128408472	128408473	+	Frame_Shift_Ins	INS	-	-	T													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caataccctggctctgtggcINSttttcatccgagaccacaag					rs17852981		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:128408472_128408473insT	uc010yzn.1	+	4	858_859	c.247_248insT	c.(247-249)CTTfs	p.L83fs	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Frame_Shift_Ins_p.L83fs|GPR17_uc010yzo.1_Frame_Shift_Ins_p.L55fs|GPR17_uc002tpd.2_Frame_Shift_Ins_p.L55fs	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	83	Helical; Name=1; (Potential).			L -> F (in Ref. 5; AAH31653).		integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		GGCTCTGTGGCTTTTCATCCGA	0.381																		38	111	---	---								T	128408473	-	T	128408472	7	5	40	1	0	1	1	0	0	0	0	0	6667	797	28	0	253	0	GPR17	2	128408472	Frame_Shift_Ins	INS	-	TCGA-DK-A1A3-01A-11D-A13W-08	7698770	128408472	114790901	149	9822										
SAP130	79595	broad.mit.edu	37	chr2	128750795	128750795	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atagtggacacggaactggtGattggggtgtaggtatgtgc	17	4	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:128750795G>C	uc002tpp.2	-	12	1653	c.1521C>G	c.(1519-1521)ATC>ATG	p.I507M	SAP130_uc002tpn.2_Missense_Mutation_p.I268M|SAP130_uc002tpo.2_Missense_Mutation_p.I252M|SAP130_uc010fmd.2_Missense_Mutation_p.I507M|SAP130_uc002tpq.1_Missense_Mutation_p.I480M	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	507					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CGGAACTGGTGATTGGGGTGT	0.453													0	0	0	0.013726	0	32	107										C	128750795	G	C	128750795	3	2	40	1	0	0	0	0	1	0	0	0	13831	1280	45	1	1770	1	SAP130	2	128750795	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	342323	128750795	114448578	150	9823										
R3HDM1	23518	broad.mit.edu	37	chr2	136389328	136389328	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aattggaacaagaaattttaGatttcattggtaataatgag	8	2	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:136389328G>C	uc002tuo.2	+	8	908	c.538G>C	c.(538-540)GAT>CAT	p.D180H	R3HDM1_uc010fni.2_Missense_Mutation_p.D178H|R3HDM1_uc002tup.2_Missense_Mutation_p.D124H|R3HDM1_uc010zbh.1_Missense_Mutation_p.D12H	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	180	R3H.						nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		AGAAATTTTAGATTTCATTGG	0.323													0	0	0	0.009535	0	30	43										C	136389328	G	C	136389328	3	2	40	1	0	0	0	0	1	0	0	0	12887	942	33	1	560	1	R3HDM1	2	136389328	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7638533	136389328	106810045	151	9824										
DARS	1615	broad.mit.edu	37	chr2	136682034	136682034	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggaagagatggcagatgccaGactggagacggaagactgcc	16	8	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:136682034G>A	uc002tux.1	-	8	783	c.599C>T	c.(598-600)TCT>TTT	p.S200F	DARS_uc010fnj.1_Missense_Mutation_p.S100F	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	200					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	GCAGATGCCAGACTGGAGACG	0.358													0	0	0	0.005443	0	26	36										A	136682034	G	A	136682034	3	1	40	1	0	0	0	0	1	0	0	0	4241	942	33	1	942	1	DARS	2	136682034	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	292706	136682034	106517339	152	9825										
NMI	9111	broad.mit.edu	37	chr2	152127234	152127234	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaaagtatgctatgtgaggTtgacctagagaacacttgac	10	7	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:152127234T>C	uc002txi.2	-	8	1227	c.897A>G	c.(895-897)CAA>CAG	p.Q299Q		NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	299					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)		CTATGTGAGGTTGACCTAGAG	0.348													0	0	0	0.01441	0	50	82										C	152127234	T	C	152127234	2	2	40	1	0	0	0	0	0	0	0	1	10497	1722	60	5		5	NMI	2	152127234	Silent	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	15445200	152127234	91072139	153	9826										
RIF1	55183	broad.mit.edu	37	chr2	152293454	152293454	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgggacttgaaatgttgcttCatttcttgttgggtccagaa	11	6	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:152293454C>T	uc002txm.2	+	12	1439	c.1309C>T	c.(1309-1311)CAT>TAT	p.H437Y	RIF1_uc002txl.2_Missense_Mutation_p.H437Y|RIF1_uc010fnv.1_Missense_Mutation_p.H401Y|RIF1_uc002txn.2_Missense_Mutation_p.H437Y|RIF1_uc002txo.2_Missense_Mutation_p.H437Y|RIF1_uc010zby.1_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	437					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATGTTGCTTCATTTCTTGTT	0.398													0	0	0	0.003163	0	14	54										T	152293454	C	T	152293454	3	4	40	1	0	0	0	0	1	0	0	0	13359	826	29	1	1351	1	RIF1	2	152293454	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	166220	152293454	90905919	154	9827										
KCNH7	90134	broad.mit.edu	37	chr2	163236516	163236516	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cattttctcgttcccagcttCgcatgtcagtgatatctgtg	8	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:163236516C>T	uc002uch.1	-	14	3190	c.2978G>A	c.(2977-2979)CGA>CAA	p.R993Q		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	993	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTCCCAGCTTCGCATGTCAGT	0.488													0	0	0	0.01441	0	77	87										T	163236516	C	T	163236516	3	4	40	1	0	0	0	0	1	0	0	0	8037	884	31	1	624	1	KCNH7	2	163236516	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	10943062	163236516	79962857	155	9828										
XIRP2	129446	broad.mit.edu	37	chr2	168105892	168105892	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggaagttttacaaagctcaAgggacattatgcaatccaaa	8	7	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:168105892A>G	uc002udx.2	+	8	8008	c.7990A>G	c.(7990-7992)AGG>GGG	p.R2664G	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R2489G|XIRP2_uc010fpq.2_Missense_Mutation_p.R2442G|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.R10G	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2489					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACAAAGCTCAAGGGACATTAT	0.408													0	0	0	0.00333	0	26	58										G	168105892	A	G	168105892	3	3	40	1	0	0	0	0	1	0	0	0	17427	63	3	5	8020	5	XIRP2	2	168105892	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	4869376	168105892	75093481	156	9829										
XIRP2	129446	broad.mit.edu	37	chr2	168106305	168106305	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gataagctcaagatggttccCaggaagcaaagagaatttag	11	6	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:168106305C>T	uc002udx.2	+	8	8421	c.8403C>T	c.(8401-8403)CCC>CCT	p.P2801P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.P2626P|XIRP2_uc010fpq.2_Silent_p.P2579P|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Silent_p.P147P	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2626					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATGGTTCCCAGGAAGCAAA	0.403													0	0	0	0.013537	0	12	62										T	168106305	C	T	168106305	2	4	40	1	0	0	0	0	0	0	0	1	17427	581	21	2		2	XIRP2	2	168106305	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	413	168106305	75093068	157	9830										
LASS6	253782	broad.mit.edu	37	chr2	169571567	169571572	+	In_Frame_Del	DEL	ATATGT	ATATGT	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attttcttgattaccttttcAtatgtcaacaatatggcccg							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:169571567_169571572delATATGT	uc002ueb.1	+	7	790_795	c.666_671delATATGT	c.(664-672)TCATATGTC>TCC	p.YV223del	LASS6_uc002uec.1_In_Frame_Del_p.YV223del	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	223_224	Helical; (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						TTACCTTTTCATATGTCAACAATATG	0.374																		104	186	---	---								-	169571572	ATATGT	-	169571567	7	5	40	1	0	1	0	1	0	0	0	0	8643	204	8	0	692	0	LASS6	2	169571567	In_Frame_Del	DEL	ATATGT	TCGA-DK-A1A3-01A-11D-A13W-08	1465262	169571567	73627806	158	9831										
CHN1	1123	broad.mit.edu	37	chr2	175742603	175742603	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccatcctggcctgtagaatCtctctcatcatgtgtctctt	6	14	4	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:175742603C>A	uc002uji.2	-	6	1044	c.514G>T	c.(514-516)GAT>TAT	p.D172Y	CHN1_uc010zeq.1_Missense_Mutation_p.D172Y|CHN1_uc002ujj.2_Intron	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	172					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCTGTAGAATCTCTCTCATCA	0.398			T	TAF15	extraskeletal myxoid chondrosarcoma								1	0	8.10497e-08	0.010504	8.35144e-08	21	82										A	175742603	C	A	175742603	3	1	40	1	0	0	0	0	1	0	0	0	3362	913	32	3	897	3	CHN1	2	175742603	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6171036	175742603	67456770	159	9832										
TTN	7273	broad.mit.edu	37	chr2	179399128	179399128	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctatcttctgcttcaaccAtgggtgctggagagcctccg	10	12	4	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179399128A>G	uc010zfg.1	-	307	94734	c.94510T>C	c.(94510-94512)TGG>CGG	p.W31504R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W25199R|TTN_uc010zfi.1_Missense_Mutation_p.W25132R|TTN_uc010zfj.1_Missense_Mutation_p.W25007R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32431							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTTCAACCATGGGTGCTGG	0.428													0	0	0	0.00623	0	36	73										G	179399128	A	G	179399128	3	3	40	1	0	0	0	0	1	0	0	0	16732	217	8	5	5785	5	TTN	2	179399128	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	3656525	179399128	63800245	160	9833										
TTN	7273	broad.mit.edu	37	chr2	179401935	179401935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggagttcttcaatagagcttCgatcacaattggtcctgtag	10	8	3	1	rs72648278		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179401935C>T	uc010zfg.1	-	305	92421	c.92197G>A	c.(92197-92199)GAA>AAA	p.E30733K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E24428K|TTN_uc010zfi.1_Missense_Mutation_p.E24361K|TTN_uc010zfj.1_Missense_Mutation_p.E24236K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31660							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAGAGCTTCGATCACAATT	0.428													0	0	0	0.000602	0	4	30										T	179401935	C	T	179401935	3	4	40	1	0	0	0	0	1	0	0	0	16732	893	31	1	8106	1	TTN	2	179401935	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2807	179401935	63797438	161	9834										
TTN	7273	broad.mit.edu	37	chr2	179464127	179464127	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atagtgtcatttgatctgctGaaacagattcaaattttatg	7	5	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179464127G>A	uc010zfg.1	-	239	48913	c.48689C>T	c.(48688-48690)TCA>TTA	p.S16230L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S9925L|TTN_uc010zfi.1_Missense_Mutation_p.S9858L|TTN_uc010zfj.1_Missense_Mutation_p.S9733L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17157							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATCTGCTGAAACAGATTC	0.383													0	0	0	0.012319	0	20	58										A	179464127	G	A	179464127	3	1	40	1	0	0	0	0	1	0	0	0	16732	1294	45	1	51592	1	TTN	2	179464127	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	62192	179464127	63735246	162	9835										
TTN	7273	broad.mit.edu	37	chr2	179604209	179604209	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgtagcaacctcctcagtaCcactttcagaggaagactcc	7	14	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:179604209C>G	uc010zfh.1	-	46	13462	c.13238G>C	c.(13237-13239)GGT>GCT	p.G4413A	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.G4346A|TTN_uc010zfj.1_Missense_Mutation_p.G4221A|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCTCAGTACCACTTTCAGA	0.453													0	0	0	0.01441	0	46	61										G	179604209	C	G	179604209	3	3	40	1	0	0	0	0	1	0	0	0	16732	507	18	4	91038	4	TTN	2	179604209	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	140082	179604209	63595164	163	9836										
ANKAR	150709	broad.mit.edu	37	chr2	190559783	190559783	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agtggtggggagccataaatGaaatagtgaacaatctgaga	13	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:190559783G>A	uc002uqw.1	+	5	1171	c.1171G>A	c.(1171-1173)GAA>AAA	p.E391K	ANKAR_uc002uqu.2_RNA	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	462						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AGCCATAAATGAAATAGTGAA	0.318													0	0	0	0.005524	0	33	31										A	190559783	G	A	190559783	3	1	40	1	0	0	0	0	1	0	0	0	623	1291	45	1	1402	1	ANKAR	2	190559783	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10955574	190559783	52639590	164	9837										
SDPR	8436	broad.mit.edu	37	chr2	192700708	192700708	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggggtccccatcggagcgctCcgcctcctcggatgttagcg	14	15	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192700708C>G	uc002utb.2	-	2	1549	c.1219G>C	c.(1219-1221)GAG>CAG	p.E407Q		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	407						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCGGAGCGCTCCGCCTCCTCG	0.617													0	0	0	0.005443	0	28	73										G	192700708	C	G	192700708	3	3	40	1	0	0	0	0	1	0	0	0	13970	864	30	1	62	1	SDPR	2	192700708	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2140925	192700708	50498665	165	9838			1	39		4	4	404	N	C	1.48029e-07
SDPR	8436	broad.mit.edu	37	chr2	192700978	192700978	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgctcactgctaggcaggtCttctgacttggtctcatttt	9	11	4	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192700978C>G	uc002utb.2	-	2	1279	c.949G>C	c.(949-951)GAC>CAC	p.D317H		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	317						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CTAGGCAGGTCTTCTGACTTG	0.552													0	0	0	0.01441	0	74	127										G	192700978	C	G	192700978	3	3	40	1	0	0	0	0	1	0	0	0	13970	913	32	1	332	1	SDPR	2	192700978	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	270	192700978	50498395	166	9839			1	39		4	4	404	N	C	1.48029e-07
SDPR	8436	broad.mit.edu	37	chr2	192701073	192701073	+	Frame_Shift_Del	DEL	C	C	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccttgaagggggagctttttCctgaggatattttctggtga							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192701073delC	uc002utb.2	-	2	1184	c.854delG	c.(853-855)GGAfs	p.G285fs		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	285						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GGAGCTTTTTCCTGAGGATAT	0.458																		130	291	---	---								-	192701073	C	-	192701073	7	5	40	1	0	1	0	1	0	0	0	0	13970	855	30	0	427	0	SDPR	2	192701073	Frame_Shift_Del	DEL	C	TCGA-DK-A1A3-01A-11D-A13W-08	95	192701073	50498300	167	9840			1	39		4	4	404	N	C	1.48029e-07
SDPR	8436	broad.mit.edu	37	chr2	192701111	192701111	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgatttgacgtgagagatttCttaatcttctctctcctctc	6	10	5	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:192701111C>G	uc002utb.2	-	2	1146	c.816G>C	c.(814-816)AAG>AAC	p.K272N		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	272						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGAGAGATTTCTTAATCTTCT	0.458													0	0	0	0.01441	0	174	332										G	192701111	C	G	192701111	3	3	40	1	0	0	0	0	1	0	0	0	13970	912	32	1	465	1	SDPR	2	192701111	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	38	192701111	50498262	168	9841			1	39		4	4	404	N	C	1.48029e-07
PGAP1	80055	broad.mit.edu	37	chr2	197791211	197791211	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tacctgatactccgggtactCaaacatgtagctcatactgc	7	12	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:197791211C>T	uc002utw.2	-	1	244	c.130G>A	c.(130-132)GAG>AAG	p.E44K	PGAP1_uc002utx.2_5'UTR|PGAP1_uc002uty.1_Missense_Mutation_p.E44K|PGAP1_uc010zgv.1_Intron|PGAP1_uc010fsj.2_Intron	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	44	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						TCCGGGTACTCAAACATGTAG	0.547													0	0	0	0.01441	0	179	145										T	197791211	C	T	197791211	3	4	40	1	0	0	0	0	1	0	0	0	11777	835	29	1	2746	1	PGAP1	2	197791211	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5090100	197791211	45408162	169	9842										
MOBKL3	25843	broad.mit.edu	37	chr2	198380840	198380840	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcggaggggacggcagtgctGaggcggaacaggccgggcac	21	10	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:198380840G>A	uc002uun.3	+	1	70	c.30G>A	c.(28-30)CTG>CTA	p.L10L	MOBKL3_uc002uum.3_Intron|MOBKL3_uc010fsn.2_Silent_p.L10L|MOBKL3_uc010fso.2_5'UTR|MOBKL3_uc010zgz.1_5'UTR	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	10					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)			CGGCAGTGCTGAGGCGGAACA	0.687													0	0	0	0.009096	0	4	6										A	198380840	G	A	198380840	2	1	40	1	0	0	0	0	0	0	0	1	9687	1277	45	1		1	MOBKL3	2	198380840	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	589629	198380840	44818533	170	9843										
C2orf69	205327	broad.mit.edu	37	chr2	200790122	200790122	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taactgtagatccagtccttCtcatactacgaatggttgcc	7	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:200790122C>G	uc010zhb.1	+	2	854	c.671C>G	c.(670-672)TCT>TGT	p.S224C		NM_153689	NP_710156	Q8N8R5	CB069_HUMAN	hypothetical protein LOC205327 precursor	224						extracellular region				central_nervous_system(1)	1						TCCAGTCCTTCTCATACTACG	0.363													0	0	0	0.007835	0	43	71										G	200790122	C	G	200790122	3	3	40	1	0	0	0	0	1	0	0	0	2188	913	32	1	677	1	C2orf69	2	200790122	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2409282	200790122	42409251	171	9844										
RAPH1	65059	broad.mit.edu	37	chr2	204324748	204324748	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttcatggtcttcaaagattCtctctgtcccaaaataaaat	4	9	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:204324748C>G	uc002vad.2	-	7	1199	c.974G>C	c.(973-975)AGA>ACA	p.R325T	RAPH1_uc002vae.2_Missense_Mutation_p.R377T|RAPH1_uc002vaf.2_Missense_Mutation_p.R377T	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	325	Ras-associating.				cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						TTCAAAGATTCTCTCTGTCCC	0.318													0	0	0	0.003271	0	34	69										G	204324748	C	G	204324748	3	3	40	1	0	0	0	0	1	0	0	0	13050	913	32	1	2817	1	RAPH1	2	204324748	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3534626	204324748	38874625	172	9845										
PLEKHM3	389072	broad.mit.edu	37	chr2	208795688	208795688	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccaccgctgcccggcagctGaacaaataggctcggagcga	13	14	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:208795688G>A	uc002vcl.2	-	5	2338	c.1848C>T	c.(1846-1848)TTC>TTT	p.F616F	PLEKHM3_uc002vcm.2_Silent_p.F616F	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	616					intracellular signal transduction		metal ion binding			ovary(1)	1						CCCGGCAGCTGAACAAATAGG	0.627													0	0	0	0.011902	0	22	20										A	208795688	G	A	208795688	2	1	40	1	0	0	0	0	0	0	0	1	12082	1281	45	1		1	PLEKHM3	2	208795688	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4470940	208795688	34403685	173	9846										
PLCD4	84812	broad.mit.edu	37	chr2	219498429	219498429	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaaaggagcactaccacttCtacgagatatcatctttctc	5	12	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:219498429C>T	uc002vij.1	+	11	1746	c.1551C>T	c.(1549-1551)TTC>TTT	p.F517F	PLCD4_uc010zkk.1_Silent_p.F67F	NM_032726	NP_116115	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	517	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)	3		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		ACTACCACTTCTACGAGATAT	0.502													0	0	0	0.006122	0	19	59										T	219498429	C	T	219498429	2	4	40	1	0	0	0	0	0	0	0	1	12033	912	32	1		1	PLCD4	2	219498429	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	10702741	219498429	23700944	174	9847										
RNF25	64320	broad.mit.edu	37	chr2	219528996	219528996	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgtggcactcccctccctttGggtgcctccgttcgggctgt	12	16	0	0	rs146227317		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:219528996G>C	uc002vit.2	-	10	1152	c.1064C>G	c.(1063-1065)CCA>CGA	p.P355R	RNF25_uc010fvw.2_Missense_Mutation_p.P243R	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	355					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCTCCCTTTGGGTGCCTCCG	0.612													0	0	0	0.004878	0	37	137										C	219528996	G	C	219528996	3	2	40	1	0	0	0	0	1	0	0	0	13485	1348	47	4	319	4	RNF25	2	219528996	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	30567	219528996	23670377	175	9848										
DNER	92737	broad.mit.edu	37	chr2	230341868	230341868	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctaattaccttctggacactGgcaggtgaatccactgagac	9	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:230341868G>A	uc002vpv.2	-	7	1396	c.1249C>T	c.(1249-1251)CAG>TAG	p.Q417*	DNER_uc010zly.1_Nonsense_Mutation_p.Q145*	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	417	Extracellular (Potential).|EGF-like 5.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TCTGGACACTGGCAGGTGAAT	0.368													0	0	0	0.005524	0	38	21										A	230341868	G	A	230341868	4	1	40	1	0	0	0	0	0	1	0	0	4667	1357	47	2	992	2	DNER	2	230341868	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10812872	230341868	12857505	176	9849										
NEU2	4759	broad.mit.edu	37	chr2	233899630	233899630	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agggcagctgtgcctactcaGacctccagagcatgggcacc	12	14	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:233899630G>A	uc010zmn.1	+	2	1006	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	336							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		TGCCTACTCAGACCTCCAGAG	0.612													0	0	0	0.01441	0	114	84										A	233899630	G	A	233899630	3	1	40	1	0	0	0	0	1	0	0	0	10342	942	33	1	1012	1	NEU2	2	233899630	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3557762	233899630	9299743	177	9850										
COL6A3	1293	broad.mit.edu	37	chr2	238266512	238266512	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtcctctctcctggctgtctTgtcctgggttaccctgaaag	10	13	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:238266512T>A	uc002vwl.2	-	22	6770	c.6485A>T	c.(6484-6486)CAA>CTA	p.Q2162L	COL6A3_uc002vwo.2_Missense_Mutation_p.Q1956L|COL6A3_uc010znj.1_Missense_Mutation_p.Q1555L|COL6A3_uc002vwp.1_5'Flank	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2162	Triple-helical region.|Collagen-like 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGGCTGTCTTGTCCTGGGTT	0.527													0	0	0	0.01441	0	166	123										A	238266512	T	A	238266512	3	1	40	1	0	0	0	0	1	0	0	0	3701	1812	63	5	3140	5	COL6A3	2	238266512	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	4366882	238266512	4932861	178	9851										
HDAC4	9759	broad.mit.edu	37	chr2	240111708	240111708	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggcagtgagaactggtggtCcaggcgcaggtccatgggca	17	9	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:240111708C>T	uc002vyk.3	-	4	952	c.160G>A	c.(160-162)GAC>AAC	p.D54N	HDAC4_uc010fyz.1_Missense_Mutation_p.D49N|HDAC4_uc010zoa.1_Missense_Mutation_p.D49N|HDAC4_uc010fza.2_Missense_Mutation_p.D54N|HDAC4_uc002vyl.1_RNA|HDAC4_uc010fyy.2_Missense_Mutation_p.D6N	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	54					B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AACTGGTGGTCCAGGCGCAGG	0.657													0	0	0	0.007413	0	18	9										T	240111708	C	T	240111708	3	4	40	1	0	0	0	0	1	0	0	0	7009	855	30	1	3190	1	HDAC4	2	240111708	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1845196	240111708	3087665	179	9852										
ATG4B	23192	broad.mit.edu	37	chr2	242598539	242598539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtaggaagcttgctgtcttcGatacgtggagctccttggcg	14	9	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr2:242598539G>A	uc002wbv.2	+	7	578	c.475G>A	c.(475-477)GAT>AAT	p.D159N	ATG4B_uc002wbu.2_Missense_Mutation_p.D85N|ATG4B_uc002wbw.2_Missense_Mutation_p.D159N|ATG4B_uc010zox.1_Missense_Mutation_p.D145N|ATG4B_uc010zoy.1_Missense_Mutation_p.D85N|ATG4B_uc010fzp.2_Missense_Mutation_p.D159N|ATG4B_uc010zoz.1_Missense_Mutation_p.D85N	NM_013325	NP_037457	Q9Y4P1	ATG4B_HUMAN	APG4 autophagy 4 homolog B isoform a	159					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		TGCTGTCTTCGATACGTGGAG	0.468													0	0	0	0.001168	0	6	41										A	242598539	G	A	242598539	3	1	40	1	0	0	0	0	1	0	0	0	1097	1058	37	1	501	1	ATG4B	2	242598539	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2486831	242598539	600834	180	9853										
OXTR	5021	broad.mit.edu	37	chr3	8809175	8809175	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccgccgctgcagcggtcttGagccgcaagttctgccagat	13	14	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:8809175G>A	uc003brc.2	-	3	1321	c.699C>T	c.(697-699)CTC>CTT	p.L233L		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	233	Cytoplasmic (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	CAGCGGTCTTGAGCCGCAAGT	0.657													0	0	0	0.009096	0	4	14										A	8809175	G	A	8809175	2	1	40	1	0	0	0	0	0	0	0	1	11338	1277	45	1		1	OXTR	3	8809175	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		8809175	189213255	181	9854										
OGG1	4968	broad.mit.edu	37	chr3	9792844	9792844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccactggggttccgtggactCccacttccaagaggtggctc	12	14	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:9792844C>T	uc003bsi.2	+	2	696	c.353C>T	c.(352-354)TCC>TTC	p.S118F	OGG1_uc003bsh.2_Missense_Mutation_p.S118F|OGG1_uc003bsj.2_Missense_Mutation_p.S118F|OGG1_uc003bsk.2_Missense_Mutation_p.S118F|OGG1_uc003bsl.2_Missense_Mutation_p.S118F|OGG1_uc003bsm.2_Missense_Mutation_p.S118F|OGG1_uc003bsn.2_Missense_Mutation_p.S118F|OGG1_uc003bso.2_Missense_Mutation_p.S118F|OGG1_uc003bsp.1_5'Flank|OGG1_uc010hcm.1_5'Flank|OGG1_uc003bsq.1_5'Flank|OGG1_uc003bsr.1_5'Flank	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	118					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					TCCGTGGACTCCCACTTCCAA	0.473								BER_DNA_glycosylases					0	0	0	0.012319	0	21	31										T	9792844	C	T	9792844	3	4	40	1	0	0	0	0	1	0	0	0	10845	855	30	1	359	1	OGG1	3	9792844	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	983669	9792844	188229586	182	9855										
IL17RC	84818	broad.mit.edu	37	chr3	9974537	9974537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttgaaacaggacgtccgctCggggggtgagtgggagcaag	18	8	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:9974537C>T	uc003bua.2	+	18	1966	c.1730C>T	c.(1729-1731)TCG>TTG	p.S577L	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_Missense_Mutation_p.S506L|IL17RC_uc011atp.1_Intron|IL17RC_uc003bud.2_Missense_Mutation_p.S47L|IL17RC_uc003bub.2_Missense_Mutation_p.S491L|IL17RC_uc010hct.2_Intron|IL17RC_uc010hcu.2_Intron|IL17RC_uc010hcv.2_Missense_Mutation_p.S474L|IL17RC_uc011atq.1_Missense_Mutation_p.S491L|IL17RC_uc003buc.2_Intron|IL17RC_uc003bue.2_Intron|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank|CRELD1_uc003buj.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	577	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GACGTCCGCTCGGGGGGTGAG	0.692											OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	4	7										T	9974537	C	T	9974537	3	4	40	1	0	0	0	0	1	0	0	0	7641	893	31	1	1800	1	IL17RC	3	9974537	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	181693	9974537	188047893	183	9856										
TMEM40	55287	broad.mit.edu	37	chr3	12783971	12783971	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acctccatagagttgaagctCatccttcaaaacgtcaggct	7	12	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:12783971C>T	uc003bxg.1	-	5	464	c.337G>A	c.(337-339)GAG>AAG	p.E113K	TMEM40_uc003bxh.1_Missense_Mutation_p.E83K|TMEM40_uc003bxi.1_Missense_Mutation_p.E37K|TMEM40_uc011auv.1_Missense_Mutation_p.E129K	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	113						integral to membrane					0						AGTTGAAGCTCATCCTTCAAA	0.507													0	0	0	0.007291	0	26	196										T	12783971	C	T	12783971	3	4	40	1	0	0	0	0	1	0	0	0	16160	835	29	1	396	1	TMEM40	3	12783971	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2809434	12783971	185238459	184	9857										
FBXL2	25827	broad.mit.edu	37	chr3	33400807	33400807	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttagccctggatggaagcaaCtggcaaagaatagatctttt	10	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:33400807C>G	uc003cfp.2	+	4	224	c.153C>G	c.(151-153)AAC>AAG	p.N51K	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_5'UTR|FBXL2_uc011axp.1_Intron|FBXL2_uc011axq.1_Intron|FBXL2_uc011axr.1_Intron|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	51	F-box.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						ATGGAAGCAACTGGCAAAGAA	0.378													0	0	0	0.008291	0	9	73										G	33400807	C	G	33400807	3	3	40	1	0	0	0	0	1	0	0	0	5716	564	20	4	167	4	FBXL2	3	33400807	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	20616836	33400807	164621623	185	9858										
ITGA9	3680	broad.mit.edu	37	chr3	37695244	37695257	+	Frame_Shift_Del	DEL	GCAGACCTGCAGCT	GCAGACCTGCAGCT	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccgttcagaggactgtgccGcagacctgcagcttcagggt							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:37695244_37695257delGCAGACCTGCAGCT	uc003chd.2	+	17	1932_1945	c.1879_1892delGCAGACCTGCAGCT	c.(1879-1893)GCAGACCTGCAGCTTfs	p.A627fs		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	627_631	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GGACTGTGCCGCAGACCTGCAGCTTCAGGGTAAA	0.505																		33	125	---	---								-	37695257	GCAGACCTGCAGCT	-	37695244	7	5	40	1	0	1	0	1	0	0	0	0	7883	1087	38	0	1945	0	ITGA9	3	37695244	Frame_Shift_Del	DEL	GCAGACCTGCAGCT	TCGA-DK-A1A3-01A-11D-A13W-08	4294437	37695244	160327186	186	9859										
GORASP1	64689	broad.mit.edu	37	chr3	39139937	39139937	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcttgggcacctgggctgtcCaggaaggagacctcaaactc	13	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:39139937C>T	uc003ciw.1	-	9	1211	c.1113G>A	c.(1111-1113)CTG>CTA	p.L371L	GORASP1_uc003civ.1_RNA|GORASP1_uc003cix.1_RNA|GORASP1_uc003ciy.1_RNA|GORASP1_uc011ayw.1_Silent_p.L276L|GORASP1_uc003ciz.1_Silent_p.L216L	NM_031899	NP_114105	Q9BQQ3	GORS1_HUMAN	Golgi reassembly stacking protein 1	371					mitotic prophase|protein transport	cytosol|Golgi apparatus|membrane				ovary(2)|central_nervous_system(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CTGGGCTGTCCAGGAAGGAGA	0.592													0	0	0	0.00245	0	15	33										T	39139937	C	T	39139937	2	4	40	1	0	0	0	0	0	0	0	1	6575	581	21	2		2	GORASP1	3	39139937	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1444693	39139937	158882493	187	9860										
CCDC13	152206	broad.mit.edu	37	chr3	42777313	42777313	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccgctgagcctcgctgttCagttgctggtccaggtggtg	14	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:42777313C>T	uc003cly.3	-	10	1341	c.1257G>A	c.(1255-1257)CTG>CTA	p.L419L		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	419	Potential.									ovary(1)	1						CCTCGCTGTTCAGTTGCTGGT	0.622													0	0	0	0.010504	0	22	63										T	42777313	C	T	42777313	2	4	40	1	0	0	0	0	0	0	0	1	2765	813	29	1		1	CCDC13	3	42777313	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3637376	42777313	155245117	188	9861										
CDCP1	64866	broad.mit.edu	37	chr3	45152268	45152268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcctcagggaagccttctgGgtagttggcagacatcaggg	14	9	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:45152268G>A	uc003com.2	-	4	856	c.721C>T	c.(721-723)CCA>TCA	p.P241S	CDCP1_uc003con.2_Missense_Mutation_p.P241S	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	241	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		AAGCCTTCTGGGTAGTTGGCA	0.542													0	0	0	0.01441	0	94	169										A	45152268	G	A	45152268	3	1	40	1	0	0	0	0	1	0	0	0	3093	1232	43	2	1821	2	CDCP1	3	45152268	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2374955	45152268	152870162	189	9862										
CCR3	1232	broad.mit.edu	37	chr3	46307616	46307616	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccacaggcacttgctcatgCacctgggcagatacatccca	8	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:46307616C>T	uc003cpg.1	+	4	1510	c.967C>T	c.(967-969)CAC>TAC	p.H323Y	CCR3_uc003cpi.1_Missense_Mutation_p.H323Y|CCR3_uc003cpj.1_Missense_Mutation_p.H323Y|CCR3_uc003cpk.1_Missense_Mutation_p.H344Y|CCR3_uc010hjb.1_Missense_Mutation_p.H341Y|CCR3_uc003cpl.1_Missense_Mutation_p.H356Y	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	323	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CTTGCTCATGCACCTGGGCAG	0.532													0	0	0	0.00632	0	29	56										T	46307616	C	T	46307616	3	4	40	1	0	0	0	0	1	0	0	0	2942	710	25	2	1036	2	CCR3	3	46307616	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1155348	46307616	151714814	190	9863										
NBEAL2	23218	broad.mit.edu	37	chr3	47044731	47044731	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgaccaaagaggccaaagtGagcaccccacccgagttgct	11	13	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:47044731G>A	uc003cqp.2	+	35	5831	c.5652G>A	c.(5650-5652)GTG>GTA	p.V1884V	NBEAL2_uc010hjm.1_Silent_p.V1261V|NBEAL2_uc010hjn.1_Silent_p.V280V|NBEAL2_uc010hjo.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1884							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		AGGCCAAAGTGAGCACCCCAC	0.637													0	0	0	0.000602	0	4	32										A	47044731	G	A	47044731	2	1	40	1	0	0	0	0	0	0	0	1	10189	1277	45	1		1	NBEAL2	3	47044731	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	737115	47044731	150977699	191	9864										
SETD2	29072	broad.mit.edu	37	chr3	47164187	47164187	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtctaattccttaatactatCatggctatcatgtgttataa	5	7	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:47164187C>T	uc003cqs.2	-	3	1992	c.1939G>A	c.(1939-1941)GAT>AAT	p.D647N	SETD2_uc003cqv.2_Missense_Mutation_p.D636N	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	647					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTAATACTATCATGGCTATCA	0.318			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.004007	0	17	110										T	47164187	C	T	47164187	3	4	40	1	0	0	0	0	1	0	0	0	14131	826	29	1	5831	1	SETD2	3	47164187	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	119456	47164187	150858243	192	9865										
STAB1	23166	broad.mit.edu	37	chr3	52538540	52538540	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgtgctggtgccatccgtctCctccttctcctccaggacca	8	18	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:52538540C>A	uc003dej.2	+	11	1288	c.1214C>A	c.(1213-1215)TCC>TAC	p.S405Y	STAB1_uc003dei.1_Missense_Mutation_p.S405Y	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	405	Extracellular (Potential).|FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCATCCGTCTCCTCCTTCTCC	0.642													1	0	7.93312e-07	0.00245	8.1363e-07	13	60										A	52538540	C	A	52538540	3	1	40	1	0	0	0	0	1	0	0	0	15236	855	30	3	1256	3	STAB1	3	52538540	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5374353	52538540	145483890	193	9866										
RFT1	91869	broad.mit.edu	37	chr3	53159984	53159984	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgaagaataaatgcattcaaGacaaaggtgatcaaccgaaa	8	7	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:53159984G>A	uc003dgj.2	-	2	144	c.90C>T	c.(88-90)GTC>GTT	p.V30V	RFT1_uc003dgk.2_Silent_p.V30V	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	30	Helical; (Potential).				carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		ATGCATTCAAGACAAAGGTGA	0.393													0	0	0	0.009096	0	3	41										A	53159984	G	A	53159984	2	1	40	1	0	0	0	0	0	0	0	1	13257	929	33	1		1	RFT1	3	53159984	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	621444	53159984	144862446	194	9867										
FLNB	2317	broad.mit.edu	37	chr3	58109122	58109122	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtggcatcggggccaggtctCgagcacgggaaggtgggtga	20	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:58109122C>T	uc003djj.2	+	21	3594	c.3429C>T	c.(3427-3429)CTC>CTT	p.L1143L	FLNB_uc010hne.2_Silent_p.L1143L|FLNB_uc003djk.2_Silent_p.L1143L|FLNB_uc010hnf.2_Silent_p.L1143L|FLNB_uc003djl.2_Silent_p.L974L|FLNB_uc003djm.2_Silent_p.L974L	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1143	Interaction with FBLP1.|Filamin 10.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGCCAGGTCTCGAGCACGGGA	0.592													0	0	0	0.01441	0	57	119										T	58109122	C	T	58109122	2	4	40	1	0	0	0	0	0	0	0	1	5934	871	31	1		1	FLNB	3	58109122	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4949138	58109122	139913308	195	9868										
CADPS	8618	broad.mit.edu	37	chr3	62423858	62423858	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatggcggacgaaagtcacgTaggcgtcggccacgtccatc	13	12	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:62423858T>C	uc003dll.2	-	28	4058	c.3698A>G	c.(3697-3699)TAC>TGC	p.Y1233C	CADPS_uc003dlj.1_Missense_Mutation_p.Y188C|CADPS_uc003dlk.1_Missense_Mutation_p.Y681C|CADPS_uc003dlm.2_Missense_Mutation_p.Y1194C|CADPS_uc003dln.2_Missense_Mutation_p.Y1154C	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1233	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GAAAGTCACGTAGGCGTCGGC	0.443													0	0	0	0.003163	0	15	36										C	62423858	T	C	62423858	3	2	40	1	0	0	0	0	1	0	0	0	2570	1638	57	5	375	5	CADPS	3	62423858	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	4314736	62423858	135598572	196	9869										
GXYLT2	727936	broad.mit.edu	37	chr3	73004392	73004393	+	Missense_Mutation	DNP	GA	GA	CT													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctgagcacgaaatccccaaGattggctggtacagccgctt							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:73004392_73004393GA>CT	uc003dpg.2	+	4	744_745	c.744_745GA>CT	c.(742-747)AAGATT>AACTTT	p.248_249KI>NF		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	248_249	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						AAATCCCCAAGATTGGCTGGTA	0.475													0	0	0	0.004672	0	8	30										CT	73004393	GA	CT	73004392	3	2	40	1	0	0	0	0	1	0	0	0	6904	933	33	1	758	1	GXYLT2	3	73004392	Missense_Mutation	DNP	GA	TCGA-DK-A1A3-01A-11D-A13W-08	10580534	73004392	125018038	197	9870										
C3orf38	285237	broad.mit.edu	37	chr3	88205273	88205273	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttaattctcagaatccttttCtaggaccacctcaagatgaa	5	10	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:88205273C>G	uc003dqw.2	+	4	789	c.478C>G	c.(478-480)CTA>GTA	p.L160V		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	160					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		GAATCCTTTTCTAGGACCACC	0.388													0	0	0	0.01441	0	48	114										G	88205273	C	G	88205273	3	3	40	1	0	0	0	0	1	0	0	0	2228	912	32	1	488	1	C3orf38	3	88205273	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	15200881	88205273	109817157	198	9871										
OR5K3	403277	broad.mit.edu	37	chr3	98110249	98110249	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atctcactttctctctgtgtCaatattctgtgattcccttc	4	12	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:98110249C>T	uc011bgw.1	+	1	740	c.740C>T	c.(739-741)TCA>TTA	p.S247L		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCTCTGTGTCAATATTCTGT	0.353													0	0	0	0.01441	0	70	134										T	98110249	C	T	98110249	3	4	40	1	0	0	0	0	1	0	0	0	11168	838	29	1	742	1	OR5K3	3	98110249	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9904976	98110249	99912181	199	9872										
GPR15	2838	broad.mit.edu	37	chr3	98251707	98251707	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcaagaacactatttaccctCagctattcttcagcttggta	6	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:98251707C>T	uc011bgy.1	+	1	830	c.830C>T	c.(829-831)TCA>TTA	p.S277L		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	277	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		TATTTACCCTCAGCTATTCTT	0.478													0	0	0	0.012319	0	22	143										T	98251707	C	T	98251707	3	4	40	1	0	0	0	0	1	0	0	0	6655	838	29	1	832	1	GPR15	3	98251707	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	141458	98251707	99770723	200	9873										
GPR128	84873	broad.mit.edu	37	chr3	100354655	100354655	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagatattcaacacttccagAaatgcttcacctgaggtaaa	6	10	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:100354655A>G	uc003duc.2	+	5	850	c.582A>G	c.(580-582)AGA>AGG	p.R194R	GPR128_uc011bhc.1_5'UTR	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	194	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						ACACTTCCAGAAATGCTTCAC	0.373													0	0	0	0.013114	0	34	56										G	100354655	A	G	100354655	2	3	40	1	0	0	0	0	0	0	0	1	6641	243	9	5		5	GPR128	3	100354655	Silent	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	2102948	100354655	97667775	201	9874										
IMPG2	50939	broad.mit.edu	37	chr3	100964653	100964654	+	Frame_Shift_Ins	INS	-	-	A													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaagtttctcaccatcttctINSaccaagtgagatccagaagt							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:100964653_100964654insA	uc003duq.1	-	12	1738_1739	c.1535_1536insT	c.(1534-1536)GTAfs	p.V512fs	IMPG2_uc011bhe.1_Frame_Shift_Ins_p.V375fs	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	512	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CACCATCTTCTACCAAGTGAGA	0.436																		73	155	---	---								A	100964654	-	A	100964653	7	5	40	1	0	1	1	0	0	0	0	0	7729	1509	53	0	2221	0	IMPG2	3	100964653	Frame_Shift_Ins	INS	-	TCGA-DK-A1A3-01A-11D-A13W-08	609998	100964653	97057777	202	9875										
RG9MTD1	54931	broad.mit.edu	37	chr3	101284754	101284754	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aagaggctctgcaattcgttCccaagagaaaacatactggt	9	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:101284754C>G	uc003duz.2	+	2	1277	c.1129C>G	c.(1129-1131)CCC>GCC	p.P377A		NM_017819	NP_060289	Q7L0Y3	MRRP1_HUMAN	RNA (guanine-9-) methyltransferase domain	377					tRNA processing	mitochondrion	methyltransferase activity|protein binding			ovary(1)	1						GCAATTCGTTCCCAAGAGAAA	0.343													0	0	0	0.01441	0	51	82										G	101284754	C	G	101284754	3	3	40	1	0	0	0	0	1	0	0	0	13271	855	30	1	1131	1	RG9MTD1	3	101284754	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	320101	101284754	96737676	203	9876										
CD47	961	broad.mit.edu	37	chr3	107778373	107778373	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttaaaccaaggccagtagcaTtctttaatgaatattcacct	5	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:107778373T>C	uc003dwt.1	-	5	797	c.617A>G	c.(616-618)AAT>AGT	p.N206S	CD47_uc003dwu.1_Missense_Mutation_p.N206S|CD47_uc003dwv.1_Missense_Mutation_p.N206S|CD47_uc003dww.1_Missense_Mutation_p.N206S	NM_001777	NP_001768	Q08722	CD47_HUMAN	CD47 antigen isoform 1 precursor	206	Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			GCCAGTAGCATTCTTTAATGA	0.284													0	0	0	0.014323	0	21	165										C	107778373	T	C	107778373	3	2	40	1	0	0	0	0	1	0	0	0	3019	1493	52	5	386	5	CD47	3	107778373	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	6493619	107778373	90244057	204	9877										
SIDT1	54847	broad.mit.edu	37	chr3	113321989	113321989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agagtgataaaaacatcatcCggaccaaggtacccactctg	8	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:113321989C>T	uc003eak.2	+	12	1906	c.1255C>T	c.(1255-1257)CGG>TGG	p.R419W	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.R419W|SIDT1_uc011big.1_Missense_Mutation_p.R172W|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_5'Flank	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	419	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						AAACATCATCCGGACCAAGGT	0.507													0	0	0	0.008291	0	9	62										T	113321989	C	T	113321989	3	4	40	1	0	0	0	0	1	0	0	0	14302	643	23	2	1301	2	SIDT1	3	113321989	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5543616	113321989	84700441	205	9878										
KIAA2018	205717	broad.mit.edu	37	chr3	113393710	113393710	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttttgtaggcgtctcattctCtgtcatttctggcatggtta	9	8	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:113393710C>T	uc003eam.2	-	3	427	c.16G>A	c.(16-18)GAG>AAG	p.E6K		NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	6					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GTCTCATTCTCTGTCATTTCT	0.383													0	0	0	0.00632	0	26	192										T	113393710	C	T	113393710	3	4	40	1	0	0	0	0	1	0	0	0	8268	922	32	1	6741	1	KIAA2018	3	113393710	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	71721	113393710	84628720	206	9879										
POLQ	10721	broad.mit.edu	37	chr3	121207358	121207358	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcaggaactggaagacattCtccttctacaccagtgggag	10	10	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121207358C>T	uc003eee.3	-	16	4549	c.4420G>A	c.(4420-4422)GAA>AAA	p.E1474K	POLQ_uc003eed.2_Missense_Mutation_p.E646K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1474					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GGAAGACATTCTCCTTCTACA	0.333								DNA_polymerases_(catalytic_subunits)					0	0	0	0.009535	0	33	171										T	121207358	C	T	121207358	3	4	40	1	0	0	0	0	1	0	0	0	12208	922	32	1	3412	1	POLQ	3	121207358	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7813648	121207358	76815072	207	9880										
GOLGB1	2804	broad.mit.edu	37	chr3	121414092	121414092	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgctttaaatcttgaacctCttcacttagagagtctttct	5	9	5	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121414092C>G	uc003eei.3	-	13	5389	c.5263G>C	c.(5263-5265)GAG>CAG	p.E1755Q	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1760Q|GOLGB1_uc003eej.3_Missense_Mutation_p.E1721Q|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1641Q|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1719Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1755	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTTGAACCTCTTCACTTAGA	0.383													0	0	0	0.01441	0	88	329										G	121414092	C	G	121414092	3	3	40	1	0	0	0	0	1	0	0	0	6565	922	32	1	4556	1	GOLGB1	3	121414092	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	206734	121414092	76608338	208	9881			2	40		5	5	3027	N	G_C	1.086075e-06
GOLGB1	2804	broad.mit.edu	37	chr3	121414425	121414425	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taacttgccatacagttcttGtttctcttgcctcacagctt	5	12	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121414425G>A	uc003eei.3	-	13	5056	c.4930C>T	c.(4930-4932)CAA>TAA	p.Q1644*	GOLGB1_uc010hrc.2_Nonsense_Mutation_p.Q1649*|GOLGB1_uc003eej.3_Nonsense_Mutation_p.Q1610*|GOLGB1_uc011bjm.1_Nonsense_Mutation_p.Q1530*|GOLGB1_uc010hrd.1_Nonsense_Mutation_p.Q1608*	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1644	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TACAGTTCTTGTTTCTCTTGC	0.408													0	0	0	0.01441	0	137	227										A	121414425	G	A	121414425	4	1	40	1	0	0	0	0	0	1	0	0	6565	1386	48	2	4889	2	GOLGB1	3	121414425	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	333	121414425	76608005	209	9882			2	40		5	5	3027	N	G_C	1.086075e-06
GOLGB1	2804	broad.mit.edu	37	chr3	121416388	121416388	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggagctttctctttctctgCtcattttctttcttcagaag	6	10	6	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121416388C>T	uc003eei.3	-	13	3093	c.2967G>A	c.(2965-2967)GAG>GAA	p.E989E	GOLGB1_uc010hrc.2_Silent_p.E994E|GOLGB1_uc003eej.3_Silent_p.E955E|GOLGB1_uc011bjm.1_Silent_p.E875E|GOLGB1_uc010hrd.1_Silent_p.E953E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	989	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCTTTCTCTGCTCATTTTCTT	0.388													0	0	0	0.01441	0	61	190										T	121416388	C	T	121416388	2	4	40	1	0	0	0	0	0	0	0	1	6565	796	28	2		2	GOLGB1	3	121416388	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1963	121416388	76606042	210	9883			2	40		5	5	3027	N	G_C	1.086075e-06
GOLGB1	2804	broad.mit.edu	37	chr3	121416969	121416969	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctgagactatggatctgttCagtgagcaggttgtcatggg	15	6	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121416969C>T	uc003eei.3	-	13	2512	c.2386G>A	c.(2386-2388)GAA>AAA	p.E796K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E801K|GOLGB1_uc003eej.3_Missense_Mutation_p.E762K|GOLGB1_uc011bjm.1_Missense_Mutation_p.E682K|GOLGB1_uc010hrd.1_Missense_Mutation_p.E760K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	796	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGGATCTGTTCAGTGAGCAGG	0.418													0	0	0	0.01441	0	94	226										T	121416969	C	T	121416969	3	4	40	1	0	0	0	0	1	0	0	0	6565	835	29	1	7433	1	GOLGB1	3	121416969	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	581	121416969	76605461	211	9884			2	40		5	5	3027	N	G_C	1.086075e-06
GOLGB1	2804	broad.mit.edu	37	chr3	121417118	121417118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctgagagagaagctggtctCtttcttcagacaaagcagtg	11	9	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:121417118C>G	uc003eei.3	-	13	2363	c.2237G>C	c.(2236-2238)AGA>ACA	p.R746T	GOLGB1_uc010hrc.2_Missense_Mutation_p.R751T|GOLGB1_uc003eej.3_Missense_Mutation_p.R712T|GOLGB1_uc011bjm.1_Missense_Mutation_p.R632T|GOLGB1_uc010hrd.1_Missense_Mutation_p.R710T	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	746	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AAGCTGGTCTCTTTCTTCAGA	0.423													0	0	0	0.01441	0	63	175										G	121417118	C	G	121417118	3	3	40	1	0	0	0	0	1	0	0	0	6565	913	32	1	7582	1	GOLGB1	3	121417118	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	149	121417118	76605312	212	9885			2	40		5	5	3027	N	G_C	1.086075e-06
KPNA1	3836	broad.mit.edu	37	chr3	122168479	122168479	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatgaccgcttgaattttatCattgggtccatctgatagat	9	7	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:122168479C>G	uc003efd.1	-	9	895	c.859G>C	c.(859-861)GAT>CAT	p.D287H	KPNA1_uc003efb.1_Missense_Mutation_p.D86H|KPNA1_uc003efc.1_Missense_Mutation_p.D86H|KPNA1_uc011bjr.1_Missense_Mutation_p.D86H|KPNA1_uc010hrh.2_Missense_Mutation_p.D86H|KPNA1_uc003efe.2_Missense_Mutation_p.D287H	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	287	Binding to RAG1.|ARM 5.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		TGAATTTTATCATTGGGTCCA	0.458													0	0	0	0.006122	0	18	102										G	122168479	C	G	122168479	3	3	40	1	0	0	0	0	1	0	0	0	8429	826	29	1	781	1	KPNA1	3	122168479	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	751361	122168479	75853951	213	9886										
KALRN	8997	broad.mit.edu	37	chr3	124165699	124165699	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaggagactcaggaactgctGaaagaatatggggaattcag	14	5	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:124165699G>A	uc003ehg.2	+	21	3640	c.3513G>A	c.(3511-3513)CTG>CTA	p.L1171L	KALRN_uc010hrv.1_Silent_p.L1162L|KALRN_uc003ehf.1_Silent_p.L1171L|KALRN_uc011bjy.1_Silent_p.L1162L|KALRN_uc003ehh.1_Silent_p.L517L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1171	Spectrin 5.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGGAACTGCTGAAAGAATATG	0.502													0	0	0	0.01441	0	71	137										A	124165699	G	A	124165699	2	1	40	1	0	0	0	0	0	0	0	1	7975	1277	45	1		1	KALRN	3	124165699	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1997220	124165699	73856731	214	9887										
MCM2	4171	broad.mit.edu	37	chr3	127327705	127327705	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcatctatcacaacaactatGatggctccctcaacactgcc	5	15	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:127327705G>A	uc003ejp.2	+	8	1324	c.1267G>A	c.(1267-1269)GAT>AAT	p.D423N	MCM2_uc011bkm.1_Missense_Mutation_p.D293N|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.D307N	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	423					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						CAACAACTATGATGGCTCCCT	0.567													0	0	0	0.01441	0	114	145										A	127327705	G	A	127327705	3	1	40	1	0	0	0	0	1	0	0	0	9386	1290	45	1	1297	1	MCM2	3	127327705	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3162006	127327705	70694725	215	9888										
PLXND1	23129	broad.mit.edu	37	chr3	129288723	129288723	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcaggacgctgcagatgacGatggacacgatgatggccgt	15	9	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:129288723G>A	uc003emx.2	-	20	3928	c.3828C>T	c.(3826-3828)ATC>ATT	p.I1276I	PLXND1_uc011blb.1_5'Flank	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1276	Helical; (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGCAGATGACGATGGACACGA	0.637													0	0	0	0.00308	0	7	48										A	129288723	G	A	129288723	2	1	40	1	0	0	0	0	0	0	0	1	12127	1048	37	1		1	PLXND1	3	129288723	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1961018	129288723	68733707	216	9889										
DNAJC13	23317	broad.mit.edu	37	chr3	132185190	132185190	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctcagatctcgtacctgaGaaggatgctgatcggatgca	12	9	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:132185190G>A	uc003eor.2	+	19	2081	c.2016G>A	c.(2014-2016)GAG>GAA	p.E672E	DNAJC13_uc010htq.1_Silent_p.E672E	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	672							heat shock protein binding			ovary(1)|breast(1)	2						TCGTACCTGAGAAGGATGCTG	0.393													0	0	0	0.00245	0	14	121										A	132185190	G	A	132185190	2	1	40	1	0	0	0	0	0	0	0	1	4632	933	33	1		1	DNAJC13	3	132185190	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2896467	132185190	65837240	217	9890										
EPHB1	2047	broad.mit.edu	37	chr3	134967280	134967280	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agccggccccggtttgcggaGattgtcaacaccctagataa	11	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:134967280G>A	uc003eqt.2	+	14	2839	c.2619G>A	c.(2617-2619)GAG>GAA	p.E873E	EPHB1_uc003equ.2_Silent_p.E434E	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	873	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGTTTGCGGAGATTGTCAACA	0.572													0	0	0	0.00499	0	17	35										A	134967280	G	A	134967280	2	1	40	1	0	0	0	0	0	0	0	1	5174	933	33	1		1	EPHB1	3	134967280	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2782090	134967280	63055150	218	9891										
MSL2	55167	broad.mit.edu	37	chr3	135913931	135913931	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcggctcgcggaaatgtagaGagcagtagcattcacggggt	16	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:135913931G>A	uc003eqx.1	-	1	758	c.25C>T	c.(25-27)CTC>TTC	p.L9F	MSL2_uc011bmb.1_5'Flank	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	9					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						GAAATGTAGAGAGCAGTAGCA	0.527													0	0	0	0.01441	0	99	199										A	135913931	G	A	135913931	3	1	40	1	0	0	0	0	1	0	0	0	9878	942	33	1	1716	1	MSL2	3	135913931	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	946651	135913931	62108499	219	9892										
ESYT3	83850	broad.mit.edu	37	chr3	138187010	138187010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggctggagtggctttcattgCttactgaccaagaagttctg	12	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:138187010C>T	uc003esk.2	+	12	1508	c.1282C>T	c.(1282-1284)CTT>TTT	p.L428F	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	428						integral to membrane|plasma membrane					0						GCTTTCATTGCTTACTGACCA	0.587													0	0	0	0.010504	0	18	39										T	138187010	C	T	138187010	3	4	40	1	0	0	0	0	1	0	0	0	5266	797	28	2	1328	2	ESYT3	3	138187010	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2273079	138187010	59835420	220	9893										
ATR	545	broad.mit.edu	37	chr3	142184050	142184050	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagccttttaaagaaatcttCtttggtttctgaagagaagc	9	6	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:142184050C>G	uc003eux.3	-	41	7052	c.6930G>C	c.(6928-6930)AAG>AAC	p.K2310N	ATR_uc003euy.1_Missense_Mutation_p.K196N	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2310					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						AAGAAATCTTCTTTGGTTTCT	0.318								Other_conserved_DNA_damage_response_genes					0	0	0	0.007413	0	18	109										G	142184050	C	G	142184050	3	3	40	1	0	0	0	0	1	0	0	0	1204	912	32	1	1032	1	ATR	3	142184050	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3997040	142184050	55838380	221	9894										
C3orf58	205428	broad.mit.edu	37	chr3	143691397	143691397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaacgggcaggtggtattcGaggcgtggggccgcttgcgc	18	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:143691397G>A	uc003evo.2	+	1	758	c.223G>A	c.(223-225)GAG>AAG	p.E75K	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	75						COPI vesicle coat|extracellular region				ovary(1)	1						GGTGGTATTCGAGGCGTGGGG	0.672													0	0	0	0.00632	0	24	51										A	143691397	G	A	143691397	3	1	40	1	0	0	0	0	1	0	0	0	2236	1059	37	1	225	1	C3orf58	3	143691397	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1507347	143691397	54331033	222	9895										
PLOD2	5352	broad.mit.edu	37	chr3	145804623	145804623	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tagattttcttctggtcctaCtatttttatagttttgattt	5	5	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:145804623C>A	uc003evs.1	-	10	1584	c.1078G>T	c.(1078-1080)GTA>TTA	p.V360L	PLOD2_uc003evq.1_5'Flank|PLOD2_uc011bnm.1_Missense_Mutation_p.V305L|PLOD2_uc003evr.1_Missense_Mutation_p.V360L	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	360					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TCTGGTCCTACTATTTTTATA	0.254													1	0	0.00198382	0.001984	0.0020089	7	23										A	145804623	C	A	145804623	3	1	40	1	0	0	0	0	1	0	0	0	12102	565	20	4	1242	4	PLOD2	3	145804623	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2113226	145804623	52217807	223	9896										
P2RY13	53829	broad.mit.edu	37	chr3	151046193	151046193	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attaggataaaaacagtccaGaaaataaactggcatatgtt	7	5	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:151046193G>C	uc003eyv.2	-	2	672	c.651C>G	c.(649-651)TTC>TTG	p.F217L	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	217	Helical; Name=5; (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			AAACAGTCCAGAAAATAAACT	0.358													0	0	0	0.00245	0	14	141										C	151046193	G	C	151046193	3	2	40	1	0	0	0	0	1	0	0	0	11350	933	33	1	417	1	P2RY13	3	151046193	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5241570	151046193	46976237	224	9897										
SLC33A1	9197	broad.mit.edu	37	chr3	155571325	155571325	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgagtggataaatagatcatGaagagtcctagtatatactg	10	4	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:155571325G>A	uc003fan.3	-	1	843	c.462C>T	c.(460-462)TTC>TTT	p.F154F	SLC33A1_uc003fao.1_Silent_p.F154F	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	154	Helical; (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AATAGATCATGAAGAGTCCTA	0.468													0	0	0	0.003271	0	33	83										A	155571325	G	A	155571325	2	1	40	1	0	0	0	0	0	0	0	1	14566	1281	45	1		1	SLC33A1	3	155571325	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4525132	155571325	42451105	225	9898										
IFT80	57560	broad.mit.edu	37	chr3	159995413	159995413	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctgcagtagtcatatctcGattagcaactgccatagcag	8	10	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:159995413G>A	uc011boy.1	-	17	2315	c.1882C>T	c.(1882-1884)CGA>TGA	p.R628*	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Nonsense_Mutation_p.R491*|IFT80_uc003fdd.1_Nonsense_Mutation_p.R311*|IFT80_uc003fde.1_Nonsense_Mutation_p.R491*	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	628						cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTCATATCTCGATTAGCAACT	0.343													0	0	0	0.007413	0	17	53										A	159995413	G	A	159995413	4	1	40	1	0	0	0	0	0	1	0	0	7564	1066	37	1	467	1	IFT80	3	159995413	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4424088	159995413	38027017	226	9899										
NMD3	51068	broad.mit.edu	37	chr3	160958933	160958933	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccagtgccattcacctcattGatccaaacaccctacaaggt	5	15	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:160958933G>C	uc003feb.1	+	10	972	c.853G>C	c.(853-855)GAT>CAT	p.D285H	NMD3_uc003fec.2_Missense_Mutation_p.D285H|NMD3_uc003fed.1_Missense_Mutation_p.D285H|NMD3_uc010hwh.2_Missense_Mutation_p.D105H	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	285					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TCACCTCATTGATCCAAACAC	0.363													0	0	0	0.006122	0	17	154										C	160958933	G	C	160958933	3	2	40	1	0	0	0	0	1	0	0	0	10488	1290	45	1	887	1	NMD3	3	160958933	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	963520	160958933	37063497	227	9900										
FNDC3B	64778	broad.mit.edu	37	chr3	172028660	172028660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaatcaccaactaccttttaGagtgggatgaggtaagctta	9	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:172028660G>C	uc003fhy.2	+	11	1415	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	FNDC3B_uc003fhz.3_Missense_Mutation_p.E415Q|FNDC3B_uc003fia.2_Missense_Mutation_p.E346Q	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	415	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CTACCTTTTAGAGTGGGATGA	0.313													0	0	0	0.006214	0	10	303										C	172028660	G	C	172028660	3	2	40	1	0	0	0	0	1	0	0	0	5970	943	33	1	1281	1	FNDC3B	3	172028660	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	11069727	172028660	25993770	228	9901										
ABCC5	10057	broad.mit.edu	37	chr3	183700753	183700753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctgtactgcaggttagactCtgttgcctgggtatactcca	11	10	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:183700753C>G	uc003fmg.2	-	6	799	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.E212Q	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	212	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGGTTAGACTCTGTTGCCTGG	0.527													0	0	0	0.00278	0	22	126										G	183700753	C	G	183700753	3	3	40	1	0	0	0	0	1	0	0	0	56	922	32	1	3779	1	ABCC5	3	183700753	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11672093	183700753	14321677	229	9902										
ECE2	9718	broad.mit.edu	37	chr3	184002817	184002817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtcaccattggagttgagtGactctgagcctgtggtggtg	15	7	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:184002817G>A	uc003fni.3	+	9	1464	c.1426G>A	c.(1426-1428)GAC>AAC	p.D476N	ECE2_uc011brh.1_Missense_Mutation_p.D329N|ECE2_uc003fnl.3_Missense_Mutation_p.D404N|ECE2_uc003fnm.3_Missense_Mutation_p.D358N|ECE2_uc003fnk.3_Missense_Mutation_p.D329N|ECE2_uc011bri.1_Missense_Mutation_p.D391N|ECE2_uc010hxv.2_Missense_Mutation_p.D120N	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	476	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGTTGAGTGACTCTGAGCC	0.552											OREG0015945	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	49	126										A	184002817	G	A	184002817	3	1	40	1	0	0	0	0	1	0	0	0	4890	1290	45	1	2024	1	ECE2	3	184002817	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	302064	184002817	14019613	230	9903										
TNK2	10188	broad.mit.edu	37	chr3	195615316	195615316	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccaggccgacccatgccgatCttctccaggtcctcattctt	7	17	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr3:195615316C>T	uc003fvu.1	-	2	687	c.144G>A	c.(142-144)AAG>AAA	p.K48K	TNK2_uc003fvs.1_Silent_p.K80K|TNK2_uc003fvt.1_Silent_p.K111K|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_5'Flank|TNK2_uc010hzx.1_Silent_p.K62K	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	48	SAM-like domain.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CCATGCCGATCTTCTCCAGGT	0.607													0	0	0	0.009096	0	4	65										T	195615316	C	T	195615316	2	4	40	1	0	0	0	0	0	0	0	1	16315	912	32	1		1	TNK2	3	195615316	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11612499	195615316	2407114	231	9904										
GAK	2580	broad.mit.edu	37	chr4	861130	861130	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcggggatcccccttcatctGacacctcactctcgtctctg	7	17	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:861130G>A	uc003gbm.3	-	21	2685	c.2486C>T	c.(2485-2487)TCA>TTA	p.S829L	GAK_uc003gbn.3_Missense_Mutation_p.S750L|GAK_uc010ibk.1_Missense_Mutation_p.S723L|GAK_uc010ibi.2_Missense_Mutation_p.S10L|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.S693L	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	829					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CCCTTCATCTGACACCTCACT	0.617													0	0	0	0.005443	0	23	114										A	861130	G	A	861130	3	1	40	1	0	0	0	0	1	0	0	0	6195	1294	45	1	1481	1	GAK	4	861130	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		861130	190293146	232	9905										
WHSC1	7468	broad.mit.edu	37	chr4	1918678	1918678	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttggatatttgagaagagcCtcgtagcttttgaaggagaa	12	5	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:1918678C>A	uc003gdz.3	+	4	1017	c.841C>A	c.(841-843)CTC>ATC	p.L281I	WHSC1_uc003geb.3_Missense_Mutation_p.L281I|WHSC1_uc003gec.3_Missense_Mutation_p.L281I|WHSC1_uc003ged.3_Missense_Mutation_p.L281I|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.L281I|WHSC1_uc003gdy.1_Missense_Mutation_p.L281I|WHSC1_uc010icd.1_Missense_Mutation_p.L281I|WHSC1_uc003gea.1_Missense_Mutation_p.L281I|WHSC1_uc010ice.1_Missense_Mutation_p.L281I|WHSC1_uc003geh.1_Missense_Mutation_p.L281I	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	281	PWWP 1.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		TGAGAAGAGCCTCGTAGCTTT	0.428			T	IGH@	MM								1	0	2.39556e-15	0.00278	2.50355e-15	23	82										A	1918678	C	A	1918678	3	1	40	1	0	0	0	0	1	0	0	0	17359	681	24	4	851	4	WHSC1	4	1918678	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1057548	1918678	189235598	233	9906										
HAUS3	79441	broad.mit.edu	37	chr4	2238119	2238119	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caatttctcagccacttcctCaaggtttccatgagttagaa	6	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:2238119C>G	uc003ges.1	-	4	1644	c.1414G>C	c.(1414-1416)GAG>CAG	p.E472Q	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Missense_Mutation_p.E472Q|HAUS3_uc003get.1_Missense_Mutation_p.E472Q	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	472	Potential.				cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						GCCACTTCCTCAAGGTTTCCA	0.323													0	0	0	0.004007	0	16	121										G	2238119	C	G	2238119	3	3	40	1	0	0	0	0	1	0	0	0	6967	835	29	1	405	1	HAUS3	4	2238119	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	319441	2238119	188916157	234	9907										
CCDC96	257236	broad.mit.edu	37	chr4	7044095	7044095	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcttcctggcttttggccgGgcgtccttccccatccctct	8	18	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:7044095G>A	uc003gjv.2	-	1	634	c.571C>T	c.(571-573)CCG>TCG	p.P191S	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	191	Glu-rich.										0						CTTTTGGCCGGGCGTccttcc	0.403													0	0	0	0.00308	0	8	33										A	7044095	G	A	7044095	3	1	40	1	0	0	0	0	1	0	0	0	2874	1232	43	2	1100	2	CCDC96	4	7044095	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4805976	7044095	184110181	235	9908										
CPZ	8532	broad.mit.edu	37	chr4	8602948	8602948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accggtcatgggaggtggtgGaggccagctccgagtacatc	16	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:8602948G>A	uc003glm.2	+	3	346	c.220G>A	c.(220-222)GAG>AAG	p.E74K	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_5'UTR|CPZ_uc003glo.2_Missense_Mutation_p.E63K|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	74	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GGAGGTGGTGGAGGCCAGCTC	0.647													0	0	0	0.00308	0	8	23										A	8602948	G	A	8602948	3	1	40	1	0	0	0	0	1	0	0	0	3839	1175	41	1	230	1	CPZ	4	8602948	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1558853	8602948	182551328	236	9909										
ARAP2	116984	broad.mit.edu	37	chr4	36212232	36212232	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attttttcttcttaaactctGaaagcattcttctactgttg	4	8	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:36212232G>A	uc003gsq.1	-	6	1605	c.1267C>T	c.(1267-1269)CAG>TAG	p.Q423*	ARAP2_uc003gsr.1_Nonsense_Mutation_p.Q423*	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	423					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTAAACTCTGAAAGCATTCT	0.368													0	0	0	0.01441	0	54	199										A	36212232	G	A	36212232	4	1	40	1	0	0	0	0	0	1	0	0	839	1299	45	1	3959	1	ARAP2	4	36212232	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	27609284	36212232	154942044	237	9910										
UGDH	7358	broad.mit.edu	37	chr4	39506886	39506886	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctctgaaacacctggatgaGaaagatccacaactatttgt	7	10	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:39506886G>A	uc003guk.1	-	9	1458	c.1142C>T	c.(1141-1143)TCT>TTT	p.S381F	UGDH_uc011byp.1_Missense_Mutation_p.S284F|UGDH_uc003gul.1_Missense_Mutation_p.S314F	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	381					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	ACCTGGATGAGAAAGATCCAC	0.358													0	0	0	0.010504	0	20	111										A	39506886	G	A	39506886	3	1	40	1	0	0	0	0	1	0	0	0	16937	942	33	1	358	1	UGDH	4	39506886	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3294654	39506886	151647390	238	9911										
NSUN7	79730	broad.mit.edu	37	chr4	40763266	40763266	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcaaactcgtgtcctttctGataatgaagagcccatatca	6	10	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:40763266G>C	uc003gvj.3	+	4	931	c.436G>C	c.(436-438)GAT>CAT	p.D146H	NSUN7_uc003gvh.2_Missense_Mutation_p.D146H|NSUN7_uc003gvi.3_Missense_Mutation_p.D146H	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						TGTCCTTTCTGATAATGAAGA	0.323													0	0	0	0.008361	0	31	141										C	40763266	G	C	40763266	3	2	40	1	0	0	0	0	1	0	0	0	10683	1290	45	1	446	1	NSUN7	4	40763266	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1256380	40763266	150391010	239	9912										
TMPRSS11F	389208	broad.mit.edu	37	chr4	68934364	68934364	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcagtgagctgctgtgagcaGccatgtgttactgatgaggc	15	8	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:68934364G>A	uc003hdt.1	-	7	776	c.727C>T	c.(727-729)CTG>TTG	p.L243L	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	243	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GCTGTGAGCAGCCATGTGTTA	0.527													0	0	0	0.008291	0	9	76										A	68934364	G	A	68934364	2	1	40	1	0	0	0	0	0	0	0	1	16240	962	34	2		2	TMPRSS11F	4	68934364	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	28171098	68934364	122219912	240	9913										
G3BP2	9908	broad.mit.edu	37	chr4	76579204	76579204	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taacatggggtggaattccaGaggaagaaacagtaccacta	11	7	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:76579204G>A	uc003hir.2	-	8	953	c.788C>T	c.(787-789)TCT>TTT	p.S263F	G3BP2_uc003his.2_Missense_Mutation_p.S263F|G3BP2_uc003hit.2_Intron	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	263					cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TGGAATTCCAGAGGAAGAAAC	0.423													0	0	0	0.008291	0	10	21										A	76579204	G	A	76579204	3	1	40	1	0	0	0	0	1	0	0	0	6142	942	33	1	680	1	G3BP2	4	76579204	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7644840	76579204	114575072	241	9914										
FRAS1	80144	broad.mit.edu	37	chr4	79199890	79199890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attgtgtttatgaagaaactGgagaatttgtgagtatcagg	12	2	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:79199890G>A	uc003hlb.2	+	10	1503	c.1063G>A	c.(1063-1065)GGA>AGA	p.G355R	FRAS1_uc003hkw.2_Missense_Mutation_p.G355R|FRAS1_uc003hky.1_Missense_Mutation_p.G59R|FRAS1_uc003hkz.2_Missense_Mutation_p.G59R	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	355	VWFC 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGAAGAAACTGGAGAATTTGT	0.328													0	0	0	0.004007	0	17	43										A	79199890	G	A	79199890	3	1	40	1	0	0	0	0	1	0	0	0	6042	1349	47	2	1101	2	FRAS1	4	79199890	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2620686	79199890	111954386	242	9915										
FRAS1	80144	broad.mit.edu	37	chr4	79238534	79238534	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcctcagtttgtcataactCatgtgccagctgctctgggc	9	12	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:79238534C>G	uc003hlb.2	+	17	2272	c.1832C>G	c.(1831-1833)TCA>TGA	p.S611*	FRAS1_uc003hkw.2_Nonsense_Mutation_p.S611*|FRAS1_uc003hky.1_Nonsense_Mutation_p.S315*|FRAS1_uc003hkz.2_Nonsense_Mutation_p.S315*|FRAS1_uc003hla.1_Nonsense_Mutation_p.S122*	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	611	FU 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGTCATAACTCATGTGCCAGC	0.607													0	0	0	0.00499	0	16	83										G	79238534	C	G	79238534	4	3	40	1	0	0	0	0	0	1	0	0	6042	838	29	1	1898	1	FRAS1	4	79238534	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	38644	79238534	111915742	243	9916										
PTPN13	5783	broad.mit.edu	37	chr4	87691109	87691109	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gttatcttgaaagtgaatggAgcctctttgaaaggactatc	10	6	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:87691109A>G	uc003hpz.2	+	29	5157	c.4677A>G	c.(4675-4677)GGA>GGG	p.G1559G	PTPN13_uc003hpy.2_Silent_p.G1564G|PTPN13_uc003hqa.2_Silent_p.G1540G|PTPN13_uc003hqb.2_Silent_p.G1368G|PTPN13_uc003hqc.1_5'UTR	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1559	PDZ 3.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AAGTGAATGGAGCCTCTTTGA	0.408													0	0	0	0.00499	0	17	116										G	87691109	A	G	87691109	2	3	40	1	0	0	0	0	0	0	0	1	12782	291	11	5		5	PTPN13	4	87691109	Silent	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	8452575	87691109	103463167	244	9917										
DSPP	1834	broad.mit.edu	37	chr4	88535250	88535250	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggcaatgatgatgctaattCagaaagtgacaataacagca	9	6	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:88535250C>T	uc003hqu.2	+	5	1556	c.1436C>T	c.(1435-1437)TCA>TTA	p.S479L		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	479	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GATGCTAATTCAGAAAGTGAC	0.378													0	0	0	0.00278	0	23	72										T	88535250	C	T	88535250	3	4	40	1	0	0	0	0	1	0	0	0	4782	838	29	1	1450	1	DSPP	4	88535250	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	844141	88535250	102619026	245	9918										
PPP3CA	5530	broad.mit.edu	37	chr4	102117268	102117268	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccggtgacttggaggaaatgGaacagctgaaagaagaaagg	15	5	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:102117268G>T	uc011cen.1	-	2	739	c.64C>A	c.(64-66)CCA>ACA	p.P22T	PPP3CA_uc003hvu.2_Missense_Mutation_p.P22T|PPP3CA_uc010ilj.2_Missense_Mutation_p.P22T|PPP3CA_uc003hvt.2_Missense_Mutation_p.P9T|PPP3CA_uc003hvs.2_Intron|PPP3CA_uc010ilk.2_Missense_Mutation_p.P22T	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	22	Catalytic.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		GGAGGAAATGGAACAGCTGAA	0.383													1	0	0.00010058	0.013537	0.000102559	13	47										T	102117268	G	T	102117268	3	4	40	1	0	0	0	0	1	0	0	0	12397	1174	41	3	1553	3	PPP3CA	4	102117268	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	13582018	102117268	89037008	246	9919										
AIMP1	9255	broad.mit.edu	37	chr4	107249297	107249297	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctatggtttctgaaaatgtGatacagtctacagcagtaac	8	7	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:107249297G>A	uc011cfg.1	+	4	340	c.288G>A	c.(286-288)GTG>GTA	p.V96V	AIMP1_uc003hyg.2_Silent_p.V96V|AIMP1_uc003hyh.2_Silent_p.V120V	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	96	Interaction with HSP90B1 (By similarity).				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						CTGAAAATGTGATACAGTCTA	0.363													0	0	0	0.012319	0	22	65										A	107249297	G	A	107249297	2	1	40	1	0	0	0	0	0	0	0	1	433	1277	45	1		1	AIMP1	4	107249297	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5132029	107249297	83904979	247	9920										
ENPEP	2028	broad.mit.edu	37	chr4	111397820	111397820	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctgcccggccagtgaggatGagagcggacagtggaaaaac	15	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:111397820G>A	uc003iab.3	+	1	592	c.250G>A	c.(250-252)GAG>AAG	p.E84K		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	84	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAGTGAGGATGAGAGCGGACA	0.637													0	0	0	0.003954	0	26	51										A	111397820	G	A	111397820	3	1	40	1	0	0	0	0	1	0	0	0	5128	1291	45	1	252	1	ENPEP	4	111397820	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4148523	111397820	79756456	248	9921										
NDST4	64579	broad.mit.edu	37	chr4	115858492	115858492	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accatgatgctattgtgaatGaagccctttctgtaccgggc	10	10	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:115858492G>A	uc003ibu.2	-	5	2068	c.1389C>T	c.(1387-1389)TTC>TTT	p.F463F	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	463	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TATTGTGAATGAAGCCCTTTC	0.438													0	0	0	0.014323	0	21	72										A	115858492	G	A	115858492	2	1	40	1	0	0	0	0	0	0	0	1	10258	1281	45	1		1	NDST4	4	115858492	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4460672	115858492	75295784	249	9922										
TRPC3	7222	broad.mit.edu	37	chr4	122853440	122853440	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcttaccttgaactccttctCtatgttggccagcttggcca	8	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:122853440C>T	uc003ieg.2	-	2	1047	c.973G>A	c.(973-975)GAG>AAG	p.E325K	TRPC3_uc010inr.2_Missense_Mutation_p.E252K|TRPC3_uc003ief.2_Missense_Mutation_p.E252K|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	240	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AACTCCTTCTCTATGTTGGCC	0.627													0	0	0	0.008291	0	10	31										T	122853440	C	T	122853440	3	4	40	1	0	0	0	0	1	0	0	0	16576	922	32	1	1836	1	TRPC3	4	122853440	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6994948	122853440	68300836	250	9923										
NAA15	80155	broad.mit.edu	37	chr4	140275244	140275244	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaaaagctgccggttatttaAccccaatggtaagtcctcaa	7	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:140275244A>G	uc003ihu.1	+	10	1335	c.1079A>G	c.(1078-1080)AAC>AGC	p.N360S		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	360					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						CGGTTATTTAACCCCAATGGT	0.318													0	0	0	0.007413	0	19	104										G	140275244	A	G	140275244	3	3	40	1	0	0	0	0	1	0	0	0	10118	43	2	5	1117	5	NAA15	4	140275244	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	17421804	140275244	50879032	251	9924										
NR3C2	4306	broad.mit.edu	37	chr4	149073701	149073701	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccagctcaaggcaaatgatGatagacacatccaagaatac	7	10	1	4	rs41511344		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:149073701G>A	uc003ilj.3	-	6	2763	c.2429C>T	c.(2428-2430)TCA>TTA	p.S810L	NR3C2_uc003ilk.3_Missense_Mutation_p.S693L|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	810	Steroid-binding.			S->M: Alters receptor specificity.	regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGCAAATGATGATAGACACAT	0.353													0	0	0	0.003163	0	15	59										A	149073701	G	A	149073701	3	1	40	1	0	0	0	0	1	0	0	0	10631	1294	45	1	541	1	NR3C2	4	149073701	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	8798457	149073701	42080575	252	9925										
FGA	2243	broad.mit.edu	37	chr4	155507934	155507934	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtggtaagtgttgcctatctCtagagggaagtaagtctttg	13	5	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:155507934C>T	uc003iod.1	-	5	705	c.647G>A	c.(646-648)AGA>AAA	p.R216K	FGA_uc003ioe.1_Missense_Mutation_p.R216K|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	216	By similarity.			SR -> RS (in Ref. 9; AA sequence).	platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTGCCTATCTCTAGAGGGAAG	0.448													0	0	0	0.009535	0	30	119										T	155507934	C	T	155507934	3	4	40	1	0	0	0	0	1	0	0	0	5830	913	32	1	2005	1	FGA	4	155507934	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6434233	155507934	35646342	253	9926										
HMGB2	3148	broad.mit.edu	37	chr4	174254236	174254236	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttacggtggccttttaggagCattggggtcctttttcttcc	11	9	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:174254236C>A	uc011ckc.1	-	2	400	c.280G>T	c.(280-282)GCT>TCT	p.A94S	HMGB2_uc003ita.3_Missense_Mutation_p.A94S|HMGB2_uc003itb.2_Missense_Mutation_p.A94S|HMGB2_uc003itc.2_Missense_Mutation_p.A94S	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	94					base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CTTTTAGGAGCATTGGGGTCC	0.403													1	0	6.34439e-16	0.01441	6.63825e-16	46	250										A	174254236	C	A	174254236	3	1	40	1	0	0	0	0	1	0	0	0	7226	710	25	4	361	4	HMGB2	4	174254236	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	18746302	174254236	16900040	254	9927										
PDLIM3	27295	broad.mit.edu	37	chr4	186429463	186429463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcatattacctcatcaaagGtgtttcccctagggctgttg	8	11	3	0	rs150809809		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr4:186429463G>A	uc003ixw.3	-	5	776	c.652C>T	c.(652-654)CCT>TCT	p.P218S	PDLIM3_uc003ixx.3_Intron|PDLIM3_uc010isi.2_Intron	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	218						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CTCATCAAAGGTGTTTCCCCT	0.403													0	0	0	0.009718	0	39	151										A	186429463	G	A	186429463	3	1	40	1	0	0	0	0	1	0	0	0	11681	1261	44	2	458	2	PDLIM3	4	186429463	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	12175227	186429463	4724813	255	9928										
DNAH5	1767	broad.mit.edu	37	chr5	13841027	13841027	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaatttaccaggtcatcaaaGatatccctttggtgcacatg	8	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:13841027G>C	uc003jfd.2	-	34	5739	c.5697C>G	c.(5695-5697)ATC>ATG	p.I1899M		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1899	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGTCATCAAAGATATCCCTTT	0.383									Kartagener_syndrome				0	0	0	0.008871	0	19	106										C	13841027	G	C	13841027	3	2	40	1	0	0	0	0	1	0	0	0	4604	932	33	1	8361	1	DNAH5	5	13841027	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		13841027	167074233	256	9929										
TRIO	7204	broad.mit.edu	37	chr5	14389431	14389431	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaatgaccagtggcgtggaaGagattccacctggcattgta	12	8	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:14389431G>A	uc003jff.2	+	25	3988	c.3982G>A	c.(3982-3984)GAG>AAG	p.E1328K	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E1279K|TRIO_uc003jfh.1_Missense_Mutation_p.E977K	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1328	DH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TGGCGTGGAAGAGATTCCACC	0.413													0	0	0	0.003163	0	12	30										A	14389431	G	A	14389431	3	1	40	1	0	0	0	0	1	0	0	0	16549	943	33	1	4080	1	TRIO	5	14389431	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	548404	14389431	166525829	257	9930										
FBXL7	23194	broad.mit.edu	37	chr5	15928098	15928098	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggaaggggctcgtccacctCctcgtcctccatcaccgggg	12	16	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:15928098C>T	uc003jfn.1	+	3	708	c.227C>T	c.(226-228)TCC>TTC	p.S76F		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	76					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TCGTCCACCTCCTCGTCCTCC	0.657													0	0	0	0.00245	0	14	35										T	15928098	C	T	15928098	3	4	40	1	0	0	0	0	1	0	0	0	5724	855	30	1	237	1	FBXL7	5	15928098	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1538667	15928098	164987162	258	9931										
MYO10	4651	broad.mit.edu	37	chr5	16781865	16781865	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttctgacagatgttcagctGaacaaacttcccaaagcgac	7	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:16781865G>C	uc003jft.3	-	6	1144	c.676C>G	c.(676-678)CAG>GAG	p.Q226E	MYO10_uc003jfu.2_Missense_Mutation_p.Q193E	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	226	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						ATGTTCAGCTGAACAAACTTC	0.423													0	0	0	0.00245	0	14	95										C	16781865	G	C	16781865	3	2	40	1	0	0	0	0	1	0	0	0	10062	1299	45	1	5644	1	MYO10	5	16781865	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	853767	16781865	164133395	259	9932										
MTMR12	54545	broad.mit.edu	37	chr5	32233926	32233926	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttgtccagttttggcttttCcacataaagagggtttttga	9	6	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:32233926C>A	uc003jhq.2	-	15	1797	c.1627G>T	c.(1627-1629)GAA>TAA	p.E543*	MTMR12_uc010iuk.2_Intron|MTMR12_uc010iul.2_Intron	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	543	Myotubularin phosphatase.|Interaction with MTM1.					cytoplasm	phosphatase activity			ovary(1)	1						TTTGGCTTTTCCACATAAAGA	0.493													1	0	1.60974e-12	0.01441	1.67832e-12	52	126										A	32233926	C	A	32233926	4	1	40	1	0	0	0	0	0	1	0	0	9941	864	30	3	624	3	MTMR12	5	32233926	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	15452061	32233926	148681334	260	9933										
ADAMTS12	81792	broad.mit.edu	37	chr5	33891861	33891861	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcctgtccgggaagcgaaccGggcctggctgaggctgtctc	15	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:33891861G>A	uc003jia.1	-	1	264	c.101C>T	c.(100-102)CCG>CTG	p.P34L	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P34L|ADAMTS12_uc003jib.1_Missense_Mutation_p.P34L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	34					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GAAGCGAACCGGGCCTGGCTG	0.527										HNSCC(64;0.19)			0	0	0	0.01441	0	42	133										A	33891861	G	A	33891861	3	1	40	1	0	0	0	0	1	0	0	0	257	1116	39	2	4779	2	ADAMTS12	5	33891861	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1657935	33891861	147023399	261	9934										
TTC23L	153657	broad.mit.edu	37	chr5	34867123	34867123	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgtacgaggaagctgctcaGatagagcagctgaggaggaa	15	7	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:34867123G>A	uc003jiu.2	+	7	892	c.789G>A	c.(787-789)CAG>CAA	p.Q263Q	TTC23L_uc003jiv.2_Silent_p.Q70Q|TTC23L_uc010iut.1_Silent_p.Q70Q	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	263	Potential.						binding			central_nervous_system(1)	1						AAGCTGCTCAGATAGAGCAGC	0.547													0	0	0	0.001168	0	5	17										A	34867123	G	A	34867123	2	1	40	1	0	0	0	0	0	0	0	1	16688	933	33	1		1	TTC23L	5	34867123	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	975262	34867123	146048137	262	9935										
RANBP3L	202151	broad.mit.edu	37	chr5	36265572	36265572	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttgttcagcactctttatatCaacactactttgcacaagag	5	10	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:36265572C>T	uc003jkh.2	-	5	812	c.319G>A	c.(319-321)GAT>AAT	p.D107N	RANBP3L_uc011cow.1_Missense_Mutation_p.D132N	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	107					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CTCTTTATATCAACACTACTT	0.308													0	0	0	0.013726	0	32	101										T	36265572	C	T	36265572	3	4	40	1	0	0	0	0	1	0	0	0	13030	826	29	1	1118	1	RANBP3L	5	36265572	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1398449	36265572	144649688	263	9936										
TTC33	23548	broad.mit.edu	37	chr5	40730373	40730373	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ataattattacctgtgatttCatctcgtatagggtagcatc	7	7	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:40730373C>T	uc003jma.2	-	3	442	c.294G>A	c.(292-294)ATG>ATA	p.M98I	TTC33_uc011cpm.1_Intron|TTC33_uc010ivg.2_Intron	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	98	TPR 2.						binding			ovary(1)	1						CCTGTGATTTCATCTCGTATA	0.368													0	0	0	0.01441	0	46	119										T	40730373	C	T	40730373	3	4	40	1	0	0	0	0	1	0	0	0	16699	826	29	1	506	1	TTC33	5	40730373	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4464801	40730373	140184887	264	9937										
HCN1	348980	broad.mit.edu	37	chr5	45462008	45462008	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcctgcagtagtggtactaaGaactgaagacaaccatccca	8	11	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:45462008G>A	uc003jok.2	-	3	976	c.951C>T	c.(949-951)TTC>TTT	p.F317F		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	317	Helical; Name=Segment S5; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GTGGTACTAAGAACTGAAGAC	0.423													0	0	0	0.004007	0	16	64										A	45462008	G	A	45462008	2	1	40	1	0	0	0	0	0	0	0	1	6996	933	33	1		1	HCN1	5	45462008	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4731635	45462008	135453252	265	9938										
AP3B1	8546	broad.mit.edu	37	chr5	77406125	77406125	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttgaactagattcgtcatttGaagaatctgaagttttagat	8	4	2	6			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:77406125G>C	uc003kfj.2	-	20	2428	c.2303C>G	c.(2302-2304)TCA>TGA	p.S768*		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	768	Glu/Ser-rich.				endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TTCGTCATTTGAAGAATCTGA	0.328									Hermansky-Pudlak_syndrome				0	0	0	0.00308	0	8	38										C	77406125	G	C	77406125	4	2	40	1	0	0	0	0	0	1	0	0	744	1294	45	1	1013	1	AP3B1	5	77406125	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	31944117	77406125	103509135	266	9939										
MTX3	345778	broad.mit.edu	37	chr5	79284998	79284998	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcagggagaagcttctcttCgaggagagcaatataagcca	12	8	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:79284998C>T	uc010jag.2	-	4	325	c.298G>A	c.(298-300)GAA>AAA	p.E100K	MTX3_uc010jah.2_Missense_Mutation_p.E100K|MTX3_uc003kge.3_Missense_Mutation_p.E39K|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	100					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		AGCTTCTCTTCGAGGAGAGCA	0.338													0	0	0	0.006214	0	8	14										T	79284998	C	T	79284998	3	4	40	1	0	0	0	0	1	0	0	0	9969	893	31	1	664	1	MTX3	5	79284998	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1878873	79284998	101630262	267	9940										
GPR98	84059	broad.mit.edu	37	chr5	90052949	90052949	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggaagactttaaaccatctCatgggattcttgaatttgca	8	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:90052949C>T	uc003kju.2	+	57	12007	c.11911C>T	c.(11911-11913)CAT>TAT	p.H3971Y	GPR98_uc003kjt.2_Missense_Mutation_p.H1677Y|GPR98_uc003kjv.2_Missense_Mutation_p.H1571Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3971	Calx-beta 26.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAAACCATCTCATGGGATTCT	0.423													0	0	0	0.012319	0	22	49										T	90052949	C	T	90052949	3	4	40	1	0	0	0	0	1	0	0	0	6721	826	29	1	12137	1	GPR98	5	90052949	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	10767951	90052949	90862311	268	9941										
FAM81B	153643	broad.mit.edu	37	chr5	94728542	94728542	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccaactgcgactgcagagGaacagccagttgaacctgat	10	12	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:94728542G>A	uc003kla.1	+	2	215	c.169G>A	c.(169-171)GAA>AAA	p.E57K	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	57										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GACTGCAGAGGAACAGCCAGT	0.403													0	0	0	0.006122	0	13	21										A	94728542	G	A	94728542	3	1	40	1	0	0	0	0	1	0	0	0	5629	1175	41	1	175	1	FAM81B	5	94728542	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4675593	94728542	86186718	269	9942										
GIN1	54826	broad.mit.edu	37	chr5	102442447	102442447	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttgacatcattggtcacagaTgtccaataataattggattc	7	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:102442447T>C	uc003koa.1	-	3	388	c.306A>G	c.(304-306)ACA>ACG	p.T102T	GIN1_uc003kob.1_Intron|GIN1_uc003koc.1_Silent_p.T102T	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	102					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		TGGTCACAGATGTCCAATAAT	0.338													0	0	0	0.00499	0	17	35										C	102442447	T	C	102442447	2	2	40	1	0	0	0	0	0	0	0	1	6386	1451	51	5		5	GIN1	5	102442447	Silent	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	7713905	102442447	78472813	270	9943										
C5orf48	389320	broad.mit.edu	37	chr5	125968328	125968328	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggaaagaaaacatgatattCaggaatgtgaatctgaaggt	11	3	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:125968328C>T	uc003kub.1	+	2	190	c.177C>T	c.(175-177)TTC>TTT	p.F59F		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	59										ovary(1)	1						ACATGATATTCAGGAATGTGA	0.289													0	0	0	0.001855	0	14	47										T	125968328	C	T	125968328	2	4	40	1	0	0	0	0	0	0	0	1	2306	825	29	1		1	C5orf48	5	125968328	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	23525881	125968328	54946932	271	9944										
RAD50	10111	broad.mit.edu	37	chr5	131895051	131895051	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaggaaatacatttgtacacGatcccaaggtaatggtgcta	9	7	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:131895051G>A	uc003kxi.2	+	2	592	c.205G>A	c.(205-207)GAT>AAT	p.D69N	RAD50_uc003kxg.1_5'UTR|RAD50_uc003kxh.2_5'UTR	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	69					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTTGTACACGATCCCAAGGT	0.214								Homologous_recombination					0	0	0	0.012319	0	22	81										A	131895051	G	A	131895051	3	1	40	1	0	0	0	0	1	0	0	0	12984	1058	37	1	211	1	RAD50	5	131895051	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5926723	131895051	49020209	272	9945										
RAD50	10111	broad.mit.edu	37	chr5	131915089	131915102	+	Frame_Shift_Del	DEL	CTGTGCTAAATAAT	CTGTGCTAAATAAT	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctcttggggtttccaaggCtgtgctaaataatgtcattt					rs138060491		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:131915089_131915102delCTGTGCTAAATAAT	uc003kxi.2	+	4	833_846	c.446_459delCTGTGCTAAATAAT	c.(445-459)GCTGTGCTAAATAATfs	p.A149fs	RAD50_uc003kxg.1_Frame_Shift_Del_p.A50fs|RAD50_uc003kxh.2_Frame_Shift_Del_p.A10fs	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	149_153					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTTCCAAGGCTGTGCTAAATAATGTCATTTTCT	0.374								Homologous_recombination										19	78	---	---								-	131915102	CTGTGCTAAATAAT	-	131915089	7	5	40	1	0	1	0	1	0	0	0	0	12984	797	28	0	460	0	RAD50	5	131915089	Frame_Shift_Del	DEL	CTGTGCTAAATAAT	TCGA-DK-A1A3-01A-11D-A13W-08	20038	131915089	49000171	273	9946										
CATSPER3	347732	broad.mit.edu	37	chr5	134332199	134332199	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcggctatagccagggcatCcgggtgagtgcactgggggt	17	9	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:134332199C>T	uc003lag.2	+	3	557	c.489C>T	c.(487-489)ATC>ATT	p.I163I		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	163	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCCAGGGCATCCGGGTGAGTG	0.547													0	0	0	0.010504	0	17	66										T	134332199	C	T	134332199	2	4	40	1	0	0	0	0	0	0	0	1	2689	845	30	1		1	CATSPER3	5	134332199	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2417110	134332199	46583061	274	9947										
H2AFY	9555	broad.mit.edu	37	chr5	134705752	134705752	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagctcttcatcattggccaCagccagcaggatgtgccggg	12	13	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:134705752C>T	uc003lam.1	-	3	463	c.253G>A	c.(253-255)GTG>ATG	p.V85M	H2AFY_uc003lao.1_Missense_Mutation_p.V85M|H2AFY_uc003lan.1_Missense_Mutation_p.V85M|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Intron|H2AFY_uc003las.1_Missense_Mutation_p.V85M|H2AFY_uc003lat.1_Missense_Mutation_p.V85M	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	85	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCATTGGCCACAGCCAGCAGG	0.562													0	0	0	0.009096	0	3	29										T	134705752	C	T	134705752	3	4	40	1	0	0	0	0	1	0	0	0	6929	478	17	2	988	2	H2AFY	5	134705752	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	373553	134705752	46209508	275	9948										
MYOT	9499	broad.mit.edu	37	chr5	137219160	137219160	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcacaaaatgatagtgtctGagaagggtcttcattcactc	9	8	4	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:137219160G>C	uc011cye.1	+	7	921	c.904G>C	c.(904-906)GAG>CAG	p.E302Q	MYOT_uc003lbv.2_Missense_Mutation_p.E302Q|MYOT_uc011cyg.1_Missense_Mutation_p.E118Q|MYOT_uc011cyh.1_Missense_Mutation_p.E187Q	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	302	Necessary for interaction with ACTA1.|Ig-like C2-type 1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GATAGTGTCTGAGAAGGGTCT	0.433													0	0	0	0.00333	0	25	88										C	137219160	G	C	137219160	3	2	40	1	0	0	0	0	1	0	0	0	10094	1291	45	1	926	1	MYOT	5	137219160	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2513408	137219160	43696100	276	9949										
KDM3B	51780	broad.mit.edu	37	chr5	137763715	137763715	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcttcacttagatgtgtctGatgctgttaatgtgatggtg	11	5	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:137763715G>C	uc003lcy.1	+	20	4893	c.4693G>C	c.(4693-4695)GAT>CAT	p.D1565H	KDM3B_uc010jew.1_Missense_Mutation_p.D1221H|KDM3B_uc011cys.1_Missense_Mutation_p.D597H	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1565	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AGATGTGTCTGATGCTGTTAA	0.428													0	0	0	0.01441	0	67	277										C	137763715	G	C	137763715	3	2	40	1	0	0	0	0	1	0	0	0	8127	1290	45	1	4771	1	KDM3B	5	137763715	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	544555	137763715	43151545	277	9950										
PCDHB8	56128	broad.mit.edu	37	chr5	140559208	140559208	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgcaggcgttcgagttccgGgtgggcgcttcagaccgcgg	17	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140559208G>C	uc011dai.1	+	1	1779	c.1593G>C	c.(1591-1593)CGG>CGC	p.R531R	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	531	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGAGTTCCGGGTGGGCGCTT	0.672													0	0	0	0.004007	0	11	108										C	140559208	G	C	140559208	2	2	40	1	0	0	0	0	0	0	0	1	11548	1219	43	4		4	PCDHB8	5	140559208	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2795493	140559208	40356052	278	9951										
PCDHB16	57717	broad.mit.edu	37	chr5	140563854	140563854	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acggctccgcgccctgcactGagctggtgccccgggcggcc	15	18	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140563854G>A	uc003liv.2	+	1	2875	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K		NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	574	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCTGCACTGAGCTGGTGCC	0.692													0	0	0	0.006214	0	9	32										A	140563854	G	A	140563854	3	1	40	1	0	0	0	0	1	0	0	0	11541	1291	45	1	1722	1	PCDHB16	5	140563854	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4646	140563854	40351406	279	9952										
PCDHB10	56126	broad.mit.edu	37	chr5	140573268	140573268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctggagaaaatggaaagatGgtttgctacattcaagagaa	11	4	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140573268G>A	uc003lix.2	+	1	1317	c.1143G>A	c.(1141-1143)ATG>ATA	p.M381I		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	381	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGAAAGATGGTTTGCTACA	0.418													0	0	0	0.00499	0	18	56										A	140573268	G	A	140573268	3	1	40	1	0	0	0	0	1	0	0	0	11535	1348	47	2	1145	2	PCDHB10	5	140573268	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	9414	140573268	40341992	280	9953										
PCDHGC5	56097	broad.mit.edu	37	chr5	140870243	140870243	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctttgcactgtggctgcctCagatccagacactggggata	11	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:140870243C>T	uc003lla.1	+	1	1436	c.1436C>T	c.(1435-1437)TCA>TTA	p.S479L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc003lky.1_Intron|PCDHGC5_uc011dbc.1_Missense_Mutation_p.S479L	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	479	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGCTGCCTCAGATCCAGAC	0.542													0	0	0	0.013726	0	33	116										T	140870243	C	T	140870243	3	4	40	1	0	0	0	0	1	0	0	0	11571	838	29	1	1438	1	PCDHGC5	5	140870243	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	296975	140870243	40045017	281	9954										
FBXO38	81545	broad.mit.edu	37	chr5	147807414	147807414	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggagggggagctcccagcctGagagttgtgacgtgcagtct	17	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:147807414G>A	uc003lpf.1	+	15	2677	c.2557G>A	c.(2557-2559)GAG>AAG	p.E853K	FBXO38_uc003lpg.1_Intron|FBXO38_uc003lph.2_Intron	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	853						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCAGCCTGAGAGTTGTGA	0.582													0	0	0	0.001168	0	6	31										A	147807414	G	A	147807414	3	1	40	1	0	0	0	0	1	0	0	0	5746	1291	45	1	2611	1	FBXO38	5	147807414	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6937171	147807414	33107846	282	9955										
CSF1R	1436	broad.mit.edu	37	chr5	149449619	149449619	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacctgcagcacttgggcctCatcacacctggcaaaagcag	10	14	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:149449619C>T	uc003lrl.2	-	9	1522	c.1327G>A	c.(1327-1329)GAG>AAG	p.E443K	CSF1R_uc011dcd.1_Missense_Mutation_p.E295K|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.E443K	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	443	Ig-like C2-type 5.|Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ACTTGGGCCTCATCACACCTG	0.617													0	0	0	0.004482	0	8	36										T	149449619	C	T	149449619	3	4	40	1	0	0	0	0	1	0	0	0	3932	835	29	1	1643	1	CSF1R	5	149449619	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1642205	149449619	31465641	283	9956										
FAM114A2	10827	broad.mit.edu	37	chr5	153407773	153407773	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taaatccaggatccccttctGctatcacatccattgtcttt	4	13	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:153407773G>A	uc003lvb.2	-	6	1154	c.566C>T	c.(565-567)GCA>GTA	p.A189V	FAM114A2_uc003lvc.2_Missense_Mutation_p.A189V|FAM114A2_uc003lvd.2_Missense_Mutation_p.A189V|FAM114A2_uc003lve.2_Missense_Mutation_p.A5V|FAM114A2_uc011dda.1_Missense_Mutation_p.A119V	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	189							purine nucleotide binding				0						ATCCCCTTCTGCTATCACATC	0.393													0	0	0	0.004878	0	36	88										A	153407773	G	A	153407773	3	1	40	1	0	0	0	0	1	0	0	0	5404	1319	46	2	987	2	FAM114A2	5	153407773	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3958154	153407773	27507487	284	9957										
ADAM19	8728	broad.mit.edu	37	chr5	156932736	156932736	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctggccgagcagcaatctgcAgaatcatgggtcatgccaaa	11	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:156932736A>G	uc003lwz.2	-	11	1135	c.1071T>C	c.(1069-1071)TCT>TCC	p.S357S	ADAM19_uc003lww.1_Silent_p.S90S|ADAM19_uc003lwy.2_5'Flank|ADAM19_uc011ddr.1_Silent_p.S288S	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	357	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGCAATCTGCAGAATCATGGG	0.602													0	0	0	0.001984	0	6	18										G	156932736	A	G	156932736	2	3	40	1	0	0	0	0	0	0	0	1	240	175	7	5		5	ADAM19	5	156932736	Silent	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	3524963	156932736	23982524	285	9958										
SOX30	11063	broad.mit.edu	37	chr5	157078609	157078609	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaccaccctggaggctctagGaccggtttcgacggcccctc	12	16	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:157078609G>A	uc003lxb.1	-	1	820	c.478C>T	c.(478-480)CCT>TCT	p.P160S	SOX30_uc003lxc.1_Missense_Mutation_p.P160S|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	160					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GAGGCTCTAGGACCGGTTTCG	0.677													0	0	0	0.001168	0	5	27										A	157078609	G	A	157078609	3	1	40	1	0	0	0	0	1	0	0	0	14952	1174	41	1	1803	1	SOX30	5	157078609	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	145873	157078609	23836651	286	9959										
CLINT1	9685	broad.mit.edu	37	chr5	157218935	157218935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaactcgccactggaagcaaCagggcctgatggggcttggt	15	10	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:157218935C>T	uc003lxj.1	-	10	1346	c.1156G>A	c.(1156-1158)GTT>ATT	p.V386I	CLINT1_uc003lxg.1_5'Flank|CLINT1_uc003lxh.1_5'UTR|CLINT1_uc003lxi.1_Missense_Mutation_p.V368I|CLINT1_uc011ddv.1_Missense_Mutation_p.V386I	NM_014666	NP_055481	Q14677	EPN4_HUMAN	epsin 4	386					endocytosis|post-Golgi vesicle-mediated transport	clathrin-coated vesicle|cytosol|Golgi apparatus|membrane|perinuclear region of cytoplasm	clathrin binding|lipid binding			ovary(2)|pancreas(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGGAAGCAACAGGGCCTGAT	0.512													0	0	0	0.008291	0	8	46										T	157218935	C	T	157218935	3	4	40	1	0	0	0	0	1	0	0	0	3531	478	17	2	733	2	CLINT1	5	157218935	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	140326	157218935	23696325	287	9960										
GABRB2	2561	broad.mit.edu	37	chr5	160761889	160761889	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttctcttaagcttaaagctGagggataacctgggatagga	11	6	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:160761889G>T	uc003lys.1	-	8	920	c.702C>A	c.(700-702)CTC>CTA	p.L234L	GABRB2_uc011deh.1_Silent_p.L73L|GABRB2_uc003lyr.1_Silent_p.L234L|GABRB2_uc003lyt.1_Silent_p.L234L|GABRB2_uc010jiu.1_Silent_p.L171L	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	234	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GCTTAAAGCTGAGGGATAACC	0.368													1	0	1.02788e-11	0.00499	1.06788e-11	16	54										T	160761889	G	T	160761889	2	4	40	1	0	0	0	0	0	0	0	1	6167	1277	45	3		3	GABRB2	5	160761889	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3542954	160761889	20153371	288	9961										
PANK3	79646	broad.mit.edu	37	chr5	167993164	167993164	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaggttctgaggcattagcAaaataatagcactcggcttg	10	8	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:167993164A>G	uc003lzz.1	-	3	789	c.489T>C	c.(487-489)TTT>TTC	p.F163F		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	163					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		AGGCATTAGCAAAATAATAGC	0.448													0	0	0	0.00632	0	28	155										G	167993164	A	G	167993164	2	3	40	1	0	0	0	0	0	0	0	1	11418	127	5	5		5	PANK3	5	167993164	Silent	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	7231275	167993164	12922096	289	9962										
CDHR2	54825	broad.mit.edu	37	chr5	176005373	176005373	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccctctgagcagggcagacCtcttccaagtggatcccgtc	10	16	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr5:176005373C>T	uc003mem.1	+	16	1648	c.1582C>T	c.(1582-1584)CTC>TTC	p.L528F	CDHR2_uc003men.1_Missense_Mutation_p.L528F	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	528	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CAGGGCAGACCTCTTCCAAGT	0.388													0	0	0	0.000602	0	4	8										T	176005373	C	T	176005373	3	4	40	1	0	0	0	0	1	0	0	0	3119	681	24	2	1640	2	CDHR2	5	176005373	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	8012209	176005373	4909887	290	9963										
CAGE1	285782	broad.mit.edu	37	chr6	7373335	7373335	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atctgacttcaagacttcctCtaattgatcctttaactgag	5	10	3	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:7373335C>G	uc003mxi.2	-	4	2030	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.E328Q|CAGE1_uc003mxk.1_Missense_Mutation_p.E328Q	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	573											0	Ovarian(93;0.0418)					AAGACTTCCTCTAATTGATCC	0.348													0	0	0	0.001984	0	7	59										G	7373335	C	G	7373335	3	3	40	1	0	0	0	0	1	0	0	0	2572	922	32	1	948	1	CAGE1	6	7373335	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		7373335	163741732	291	9964										
DSP	1832	broad.mit.edu	37	chr6	7580702	7580702	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagagaatctcaggagggtgGaagaagacatccaacagcaa	12	8	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:7580702G>A	uc003mxp.1	+	23	4558	c.4279G>A	c.(4279-4281)GAA>AAA	p.E1427K	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1427	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGGAGGGTGGAAGAAGACAT	0.483													0	0	0	0.010729	0	11	58										A	7580702	G	A	7580702	3	1	40	1	0	0	0	0	1	0	0	0	4781	1175	41	1	4369	1	DSP	6	7580702	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	207367	7580702	163534365	292	9965										
DSP	1832	broad.mit.edu	37	chr6	7581076	7581076	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtttcccaggagaggactgtGaaggaccaggatatcacgcg	14	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:7581076G>A	uc003mxp.1	+	23	4932	c.4653G>A	c.(4651-4653)GTG>GTA	p.V1551V	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1551	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGAGGACTGTGAAGGACCAGG	0.522													0	0	0	0.01441	0	47	80										A	7581076	G	A	7581076	2	1	40	1	0	0	0	0	0	0	0	1	4781	1277	45	1		1	DSP	6	7581076	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	374	7581076	163533991	293	9966										
TXNDC5	81567	broad.mit.edu	37	chr6	8064557	8064557	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agtccctcttcttgctgccaCcgcccggggcggcctcacaa	10	18	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:8064557C>T	uc003mxw.2	-	1	91	c.-197G>A	c.(-199--195)CGGTG>CGATG		MUTED_uc003mxy.2_Missense_Mutation_p.G18D|MUTED_uc010joc.2_Translation_Start_Site|MUTED_uc010job.2_RNA	NM_001145549	NP_001139021	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 3						anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					CTTGCTGCCACCGCCCGGGGC	0.667													0	0	0	0.00308	0	8	19										T	8064557	C	T	8064557	1	4	40	1	0	0	0	0	0	0	0	0	16796	507	18	2		2	TXNDC5	6	8064557	Translation_Start_Site	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	483481	8064557	163050510	294	9967										
SYCP2L	221711	broad.mit.edu	37	chr6	10913109	10913109	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attttcccaagaatactctaTgggactcagtgacacttccg	7	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:10913109T>C	uc003mzo.2	+	14	1317	c.1021T>C	c.(1021-1023)TGG>CGG	p.W341R	SYCP2L_uc011din.1_Missense_Mutation_p.W182R|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	341						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GAATACTCTATGGGACTCAGT	0.348													0	0	0	0.00632	0	29	53										C	10913109	T	C	10913109	3	2	40	1	0	0	0	0	1	0	0	0	15430	1464	51	5	1075	5	SYCP2L	6	10913109	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	2848552	10913109	160201958	295	9968										
NHLRC1	378884	broad.mit.edu	37	chr6	18122174	18122174	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccattctgaggggtggtctCcacaccccaaggtaaggaga	12	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:18122174C>G	uc003ncl.1	-	1	678	c.664G>C	c.(664-666)GAG>CAG	p.E222Q		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	222	NHL 3.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			GGGGTGGTCTCCACACCCCAA	0.552													0	0	0	0.010729	0	12	22										G	18122174	C	G	18122174	3	3	40	1	0	0	0	0	1	0	0	0	10405	864	30	1	527	1	NHLRC1	6	18122174	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7209065	18122174	152992893	296	9969										
NHLRC1	378884	broad.mit.edu	37	chr6	18122786	18122786	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagcaggctgatctccgcctCgcgcatgagctcatgcagcg	13	14	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:18122786C>A	uc003ncl.1	-	1	66	c.52G>T	c.(52-54)GAG>TAG	p.E18*		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	18					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ATCTCCGCCTCGCGCATGAGC	0.711													1	0	0.00909568	0.009096	0.00917903	4	17										A	18122786	C	A	18122786	4	1	40	1	0	0	0	0	0	1	0	0	10405	893	31	3	1139	3	NHLRC1	6	18122786	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	612	18122786	152992281	297	9970										
BTN3A3	10384	broad.mit.edu	37	chr6	26446154	26446154	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagctctggtgggggtgtatCctgcatcatcagaaattccc	11	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:26446154C>T	uc003nhz.2	+	5	836	c.656C>T	c.(655-657)TCC>TTC	p.S219F	BTN3A3_uc003nia.2_Missense_Mutation_p.S177F|BTN3A3_uc011dkn.1_Missense_Mutation_p.S177F	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	219	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0						GGGGGTGTATCCTGCATCATC	0.552													0	0	0	0.01441	0	54	81										T	26446154	C	T	26446154	3	4	40	1	0	0	0	0	1	0	0	0	1564	855	30	1	666	1	BTN3A3	6	26446154	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	8323368	26446154	144668913	298	9971										
BTN2A1	11120	broad.mit.edu	37	chr6	26459743	26459743	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtggggcccactgatcccatCttggccacggttggagaaaa	13	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:26459743C>T	uc003nib.1	+	3	329	c.117C>T	c.(115-117)ATC>ATT	p.I39I	BTN2A1_uc003nic.1_Silent_p.I39I|BTN2A1_uc003nid.1_5'UTR|BTN2A1_uc011dko.1_5'UTR	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	39	Extracellular (Potential).|Ig-like V-type.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						CTGATCCCATCTTGGCCACGG	0.522													0	0	0	0.00308	0	8	41										T	26459743	C	T	26459743	2	4	40	1	0	0	0	0	0	0	0	1	1560	903	32	1		1	BTN2A1	6	26459743	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	13589	26459743	144655324	299	9972										
BTN1A1	696	broad.mit.edu	37	chr6	26501556	26501556	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggtctccccagatgtctgctCaccctcattctcctccagct	6	18	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:26501556C>T	uc003nif.3	+	1	62	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	14						extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GATGTCTGCTCACCCTCATTC	0.483													0	0	0	0.00278	0	21	67										T	26501556	C	T	26501556	2	4	40	1	0	0	0	0	0	0	0	1	1559	813	29	1		1	BTN1A1	6	26501556	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	41813	26501556	144613511	300	9973										
HIST1H4I	8294	broad.mit.edu	37	chr6	27107327	27107327	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acggagcacgccaagcgcaaGacggtcaccgccatggacgt	13	14	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:27107327G>A	uc003niy.1	+	1	240	c.240G>A	c.(238-240)AAG>AAA	p.K80K	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	80					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CCAAGCGCAAGACGGTCACCG	0.597			T	BCL6	NHL								0	0	0	0.004482	0	7	44										A	27107327	G	A	27107327	2	1	40	1	0	0	0	0	0	0	0	1	7173	933	33	1		1	HIST1H4I	6	27107327	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	605771	27107327	144007740	301	9974										
HIST1H2AL	8332	broad.mit.edu	37	chr6	27833492	27833492	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctgtgctactgcccaagaaGaccgagagtcaccacaaggc	11	13	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:27833492G>A	uc003njw.2	+	1	386	c.360G>A	c.(358-360)AAG>AAA	p.K120K		NM_003511	NP_003502	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	120					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						TGCCCAAGAAGACCGAGAGTC	0.522													0	0	0	0.014323	0	19	88										A	27833492	G	A	27833492	2	1	40	1	0	0	0	0	0	0	0	1	7138	933	33	1		1	HIST1H2AL	6	27833492	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	726165	27833492	143281575	302	9975										
ZNF165	7718	broad.mit.edu	37	chr6	28056944	28056944	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaaagctttgcagagagctCagatcttactagacatcggc	10	9	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:28056944C>T	uc003nkg.2	+	5	2238	c.1154C>T	c.(1153-1155)TCA>TTA	p.S385L	ZNF165_uc003nkh.2_Missense_Mutation_p.S385L|ZNF165_uc003nki.3_Missense_Mutation_p.S385L|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	385	C2H2-type 3.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCAGAGAGCTCAGATCTTACT	0.453													0	0	0	0.008871	0	20	64										T	28056944	C	T	28056944	3	4	40	1	0	0	0	0	1	0	0	0	17737	838	29	1	1164	1	ZNF165	6	28056944	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	223452	28056944	143058123	303	9976										
TRIM10	10107	broad.mit.edu	37	chr6	30126201	30126201	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggagctcccttgctggcctcTcattcttctcctccagttct	7	16	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:30126201T>C	uc003npo.3	-	3	807	c.731A>G	c.(730-732)GAG>GGG	p.E244G	TRIM10_uc003npn.2_Missense_Mutation_p.E244G	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	244						cytoplasm	zinc ion binding				0						TGCTGGCCTCTCATTCTTCTC	0.537													0	0	0	0.006999	0	41	219										C	30126201	T	C	30126201	3	2	40	1	0	0	0	0	1	0	0	0	16483	1551	54	5	822	5	TRIM10	6	30126201	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	2069257	30126201	140988866	304	9977										
MDC1	9656	broad.mit.edu	37	chr6	30681764	30681764	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggtccctcagacggtgactCaccccagggctcaaaacctt	9	15	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:30681764C>T	uc003nrg.3	-	3	773	c.333G>A	c.(331-333)GTG>GTA	p.V111V	MDC1_uc003nrf.3_5'Flank|MDC1_uc011dmp.1_Intron|MDC1_uc003nrh.1_Intron|MDC1_uc003nri.2_Silent_p.V111V	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	111	Interaction with the MRN complex.|Interaction with CHEK2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GACGGTGACTCACCCCAGGGC	0.542								Other_conserved_DNA_damage_response_genes					0	0	0	0.00499	0	18	75										T	30681764	C	T	30681764	2	4	40	1	0	0	0	0	0	0	0	1	9403	813	29	1		1	MDC1	6	30681764	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	555563	30681764	140433303	305	9978										
CSNK2B	1460	broad.mit.edu	37	chr6	31635725	31635725	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cactatcgacaagctctagaCatgatcttggacctggagcc	9	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:31635725C>G	uc003nvr.1	+	3	493	c.153C>G	c.(151-153)GAC>GAG	p.D51E	BAT4_uc003nvn.2_5'Flank|BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_Missense_Mutation_p.D51E|CSNK2B_uc003nvs.1_Missense_Mutation_p.D51E	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	51					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						AAGCTCTAGACATGATCTTGG	0.463													0	0	0	0.008871	0	21	63										G	31635725	C	G	31635725	3	3	40	1	0	0	0	0	1	0	0	0	3959	477	17	4	159	4	CSNK2B	6	31635725	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	953961	31635725	139479342	306	9979										
EGFL8	80864	broad.mit.edu	37	chr6	32134565	32134565	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagggctggaagaagcggcaCccgggggcgctcacctgtga	17	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:32134565C>T	uc003oab.1	+	4	370	c.312C>T	c.(310-312)CAC>CAT	p.H104H	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Silent_p.H104H	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	104	EMI.					extracellular region|integral to membrane	calcium ion binding				0						AGAAGCGGCACCCGGGGGCGC	0.667													0	0	0	0.010729	0	10	31										T	32134565	C	T	32134565	2	4	40	1	0	0	0	0	0	0	0	1	4965	506	18	2		2	EGFL8	6	32134565	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	498840	32134565	138980502	307	9980										
RPS18	6222	broad.mit.edu	37	chr6	33244172	33244172	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctctttttacctgcagccttCgtgtccgaggccagcacacc	8	16	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33244172C>T	uc003odp.1	+	6	433	c.388C>T	c.(388-390)CGT>TGT	p.R130C	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	130					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						CTGCAGCCTTCGTGTCCGAGG	0.512													0	0	0	0.009096	0	4	27										T	33244172	C	T	33244172	3	4	40	1	0	0	0	0	1	0	0	0	13628	884	31	1	410	1	RPS18	6	33244172	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1109607	33244172	137870895	308	9981										
ZBTB22	9278	broad.mit.edu	37	chr6	33283235	33283235	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggccttcccacaatggcacaGaaagatcttattcccgtccc	7	15	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33283235G>A	uc003oeb.2	-	2	1611	c.1459C>T	c.(1459-1461)CTG>TTG	p.L487L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.L487L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	487	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAATGGCACAGAAAGATCTTA	0.627													0	0	0	0.004289	0	38	141										A	33283235	G	A	33283235	2	1	40	1	0	0	0	0	0	0	0	1	17527	933	33	1		1	ZBTB22	6	33283235	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	39063	33283235	137831832	309	9982										
ZBTB22	9278	broad.mit.edu	37	chr6	33284430	33284430	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagatggaggtcatgcctttGagtaggacctgatcatggaa	14	6	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33284430G>C	uc003oeb.2	-	2	416	c.264C>G	c.(262-264)CTC>CTG	p.L88L	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.L88L	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	88	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCATGCCTTTGAGTAGGACCT	0.602													0	0	0	0.004656	0	24	155										C	33284430	G	C	33284430	2	2	40	1	0	0	0	0	0	0	0	1	17527	1277	45	1		1	ZBTB22	6	33284430	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1195	33284430	137830637	310	9983										
DAXX	1616	broad.mit.edu	37	chr6	33287200	33287200	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtttgcttcttctccttccGagattttttgcaggggggac	11	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33287200G>A	uc003oec.2	-	6	2101	c.1897C>T	c.(1897-1899)CGG>TGG	p.R633W	ZBTB22_uc003oeb.2_5'Flank|ZBTB22_uc010juu.2_5'Flank|DAXX_uc011drd.1_Missense_Mutation_p.R558W|DAXX_uc011dre.1_Missense_Mutation_p.R645W|DAXX_uc003oed.2_Missense_Mutation_p.R633W	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	633	Nuclear localization signal (Potential).|Interaction with SPOP.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						TTCTCCTTCCGAGATTTTTTG	0.507			Mis|F|N		Pancreatic neuroendocrine tumors								0	0	0	0.01441	0	47	225										A	33287200	G	A	33287200	3	1	40	1	0	0	0	0	1	0	0	0	4243	1057	37	1	337	1	DAXX	6	33287200	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2770	33287200	137827867	311	9984										
CUTA	51596	broad.mit.edu	37	chr6	33385311	33385311	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caagtaacaaaggctgcagaGaccgagcccggaacgtagcc	12	12	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:33385311G>A	uc003oej.1	-	2	492	c.204C>T	c.(202-204)GTC>GTT	p.V68V	CUTA_uc003oek.1_Silent_p.V45V|CUTA_uc003oel.1_Silent_p.V45V|CUTA_uc003oem.1_Silent_p.V45V|CUTA_uc003oen.1_Silent_p.V87V|SYNGAP1_uc003oeo.1_5'Flank|SYNGAP1_uc011dri.1_5'Flank|SYNGAP1_uc010juy.2_5'Flank	NM_001014840	NP_001014840	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog isoform	68					protein localization|response to metal ion	membrane	enzyme binding				0						AGGCTGCAGAGACCGAGCCCG	0.612													0	0	0	0.004289	0	34	86										A	33385311	G	A	33385311	2	1	40	1	0	0	0	0	0	0	0	1	4062	929	33	1		1	CUTA	6	33385311	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	98111	33385311	137729756	312	9985										
SCUBE3	222663	broad.mit.edu	37	chr6	35213121	35213121	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acatcaaccccccacccaagCgcaagatccttatcgtggta	6	16	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:35213121C>T	uc003okf.1	+	19	2524	c.2518C>T	c.(2518-2520)CGC>TGC	p.R840C	SCUBE3_uc003okg.1_Missense_Mutation_p.R839C|SCUBE3_uc003okh.1_Missense_Mutation_p.R727C	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	840	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CCCACCCAAGCGCAAGATCCT	0.557													0	0	0	0.008871	0	20	83										T	35213121	C	T	35213121	3	4	40	1	0	0	0	0	1	0	0	0	13946	768	27	2	2592	2	SCUBE3	6	35213121	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1827810	35213121	135901946	313	9986										
LRFN2	57497	broad.mit.edu	37	chr6	40400146	40400146	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggttacccccaaaactaaagGacaagggtggggcaaagggt	14	8	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:40400146G>A	uc003oph.1	-	2	1172	c.707C>T	c.(706-708)TCC>TTC	p.S236F		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	236	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAAACTAAAGGACAAGGGTGG	0.597													0	0	0	0.004007	0	9	35										A	40400146	G	A	40400146	3	1	40	1	0	0	0	0	1	0	0	0	8938	1174	41	1	1670	1	LRFN2	6	40400146	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5187025	40400146	130714921	314	9987										
NCR2	9436	broad.mit.edu	37	chr6	41303625	41303625	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaaggaccacatggcctggcGagccctacacccactgctac	9	16	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:41303625G>A	uc003oqh.2	+	1	98	c.11G>A	c.(10-12)CGA>CAA	p.R4Q	NCR2_uc003oqi.2_Missense_Mutation_p.R4Q|NCR2_uc003oqj.2_Missense_Mutation_p.R4Q	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	4					cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					ATGGCCTGGCGAGCCCTACAC	0.622													0	0	0	0.004672	0	3	4										A	41303625	G	A	41303625	3	1	40	1	0	0	0	0	1	0	0	0	10238	1058	37	1	13	1	NCR2	6	41303625	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	903479	41303625	129811442	315	9988										
NFKBIE	4794	broad.mit.edu	37	chr6	44227792	44227792	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccacttacttcctcagtcagGtcctggggcgtctcatcctc	8	16	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:44227792G>T	uc003oxe.1	-	5	1450	c.1425C>A	c.(1423-1425)GAC>GAA	p.D475E	SLC35B2_uc003oxd.2_5'Flank|SLC35B2_uc011dvt.1_5'Flank|SLC35B2_uc011dvu.1_5'Flank	NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	475					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCTCAGTCAGGTCCTGGGGCG	0.517													1	0	3.07112e-06	0.010729	3.14246e-06	12	51										T	44227792	G	T	44227792	3	4	40	1	0	0	0	0	1	0	0	0	10380	1252	44	4	85	4	NFKBIE	6	44227792	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2924167	44227792	126887275	316	9989										
TDRD6	221400	broad.mit.edu	37	chr6	46658620	46658620	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgcatggcaaaaaaatctaGaattaaaatgtacaatattt	5	4	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:46658620G>T	uc003oyj.2	+	1	2755	c.2755G>T	c.(2755-2757)GAA>TAA	p.E919*	TDRD6_uc010jze.2_Nonsense_Mutation_p.E913*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	919					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AAAAAATCTAGAATTAAAATG	0.338													1	0	3.8784e-16	0.012319	4.06287e-16	20	155										T	46658620	G	T	46658620	4	4	40	1	0	0	0	0	0	1	0	0	15731	943	33	3	2757	3	TDRD6	6	46658620	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2430828	46658620	124456447	317	9990										
MEP1A	4224	broad.mit.edu	37	chr6	46794205	46794205	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaggacagtgctcaggctgGagaagtggatcacaccttgt	13	9	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:46794205G>A	uc010jzh.1	+	9	935	c.893G>A	c.(892-894)GGA>GAA	p.G298E	MEP1A_uc011dwg.1_Missense_Mutation_p.G20E|MEP1A_uc011dwh.1_Missense_Mutation_p.G326E|MEP1A_uc011dwi.1_Missense_Mutation_p.G198E	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	298	Extracellular (Potential).|MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GCTCAGGCTGGAGAAGTGGAT	0.488													0	0	0	0.01441	0	48	81										A	46794205	G	A	46794205	3	1	40	1	0	0	0	0	1	0	0	0	9475	1174	41	1	927	1	MEP1A	6	46794205	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	135585	46794205	124320862	318	9991										
PKHD1	5314	broad.mit.edu	37	chr6	51908451	51908451	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taccacacagaatggacacaGggagttgacccttggaggta	12	9	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:51908451G>A	uc003pah.1	-	26	3069	c.2793C>T	c.(2791-2793)CCC>CCT	p.P931P	PKHD1_uc003pai.2_Silent_p.P931P	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	931	IPT/TIG 4.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AATGGACACAGGGAGTTGACC	0.473													0	0	0	0.003755	0	37	34										A	51908451	G	A	51908451	2	1	40	1	0	0	0	0	0	0	0	1	11971	987	35	2		2	PKHD1	6	51908451	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5114246	51908451	119206616	319	9992										
GJA10	84694	broad.mit.edu	37	chr6	90604653	90604653	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgaaaggatgtctgctgcgtActtatgtcttacacatcttg	9	8	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:90604653A>G	uc011eaa.1	+	1	466	c.466A>G	c.(466-468)ACT>GCT	p.T156A		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	156	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TCTGCTGCGTACTTATGTCTT	0.438													0	0	0	0.01441	0	59	83										G	90604653	A	G	90604653	3	3	40	1	0	0	0	0	1	0	0	0	6401	391	14	5	468	5	GJA10	6	90604653	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	38696202	90604653	80510414	320	9993										
EPHA7	2045	broad.mit.edu	37	chr6	94068097	94068097	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acgagagcactgaagatcttGagaggaagacttgtagaacc	12	7	1	6			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:94068097G>A	uc003poe.2	-	4	1106	c.865C>T	c.(865-867)CAA>TAA	p.Q289*	EPHA7_uc003pof.2_Nonsense_Mutation_p.Q289*|EPHA7_uc011eac.1_Nonsense_Mutation_p.Q289*	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	289	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGAAGATCTTGAGAGGAAGAC	0.413													0	0	0	0.013537	0	11	25										A	94068097	G	A	94068097	4	1	40	1	0	0	0	0	0	1	0	0	5172	1299	45	1	2187	1	EPHA7	6	94068097	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3463444	94068097	77046970	321	9994										
FHL5	9457	broad.mit.edu	37	chr6	97051647	97051647	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accaattgaatctgattctaAggtaagtctcacctcaattt	5	9	4	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:97051647A>T	uc003pos.1	+	3	563	c.158A>T	c.(157-159)AAG>ATG	p.K53M	FHL5_uc003pot.1_Missense_Mutation_p.K53M	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	53	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TCTGATTCTAAGGTAAGTCTC	0.358													0	0	0	0.00874	0	42	64										T	97051647	A	T	97051647	3	4	40	1	0	0	0	0	1	0	0	0	5881	86	3	5	160	5	FHL5	6	97051647	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	2983550	97051647	74063420	322	9995										
SIM1	6492	broad.mit.edu	37	chr6	100841697	100841697	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctgcggagaggccgtgtcGgtcaagggacttccgcccca	15	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:100841697G>A	uc003pqj.3	-	10	1443	c.1236C>T	c.(1234-1236)ACC>ACT	p.T412T	SIM1_uc010kcu.2_Silent_p.T412T	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	412	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AGGCCGTGTCGGTCAAGGGAC	0.572													0	0	0	0.014323	0	21	22										A	100841697	G	A	100841697	2	1	40	1	0	0	0	0	0	0	0	1	14323	1103	39	2		2	SIM1	6	100841697	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3790050	100841697	70273370	323	9996										
TRAF3IP2	10758	broad.mit.edu	37	chr6	111913025	111913025	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaactgtcttcactgtcctCcagaacttgagtgcgcaggc	10	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:111913025C>T	uc011ebc.1	-	3	880	c.265G>A	c.(265-267)GAG>AAG	p.E89K	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.E89K|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.E89K|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.E89K|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.E89K	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	98					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		TCACTGTCCTCCAGAACTTGA	0.567													0	0	0	0.004289	0	37	55										T	111913025	C	T	111913025	3	4	40	1	0	0	0	0	1	0	0	0	16438	864	30	1	1464	1	TRAF3IP2	6	111913025	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11071328	111913025	59202042	324	9997										
C6orf174	387104	broad.mit.edu	37	chr6	127797109	127797109	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtcgtggtgccgcgcgctgtCgtggccgccggacttgtact	16	13	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:127797109C>T	uc003qbd.2	-	6	2927	c.2062G>A	c.(2062-2064)GAC>AAC	p.D688N	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	688	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CGCGCGCTGTCGTGGCCGCCG	0.652													0	0	0	0.003954	0	22	37										T	127797109	C	T	127797109	3	4	40	1	0	0	0	0	1	0	0	0	2345	884	31	1	789	1	C6orf174	6	127797109	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	15884084	127797109	43317958	325	9998										
MYB	4602	broad.mit.edu	37	chr6	135521495	135521495	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acaggaatctgatgaatctgGaattgttgctgagtttcaag	11	5	3	3	rs113182184	byFrequency	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:135521495G>A	uc003qfc.2	+	12	1728	c.1529G>A	c.(1528-1530)GGA>GAA	p.G510E	MYB_uc003qfh.2_Missense_Mutation_p.G631E|MYB_uc003qfi.2_Missense_Mutation_p.G615E|MYB_uc010kgi.2_Missense_Mutation_p.G510E|MYB_uc003qfq.2_Missense_Mutation_p.G628E|MYB_uc010kgj.2_Missense_Mutation_p.G475E|MYB_uc003qfo.2_Missense_Mutation_p.G425E|MYB_uc003qfu.2_Missense_Mutation_p.G507E|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Missense_Mutation_p.G136E|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.G322E|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.G510E	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	510					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		GATGAATCTGGAATTGTTGCT	0.428			T	NFIB	adenoid cystic carcinoma								0	0	0	0.00874	0	45	50										A	135521495	G	A	135521495	3	1	40	1	0	0	0	0	1	0	0	0	10007	1174	41	1	1942	1	MYB	6	135521495	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7724386	135521495	35593572	326	9999										
PDE7B	27115	broad.mit.edu	37	chr6	136502427	136502427	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgggagatgagcaagcagtgGagtgaaagggtctgtgaaga	18	3	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:136502427G>C	uc003qgp.2	+	11	1314	c.1011G>C	c.(1009-1011)TGG>TGC	p.W337C	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Missense_Mutation_p.W389C	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	337	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GCAAGCAGTGGAGTGAAAGGG	0.438													0	0	0	0.004656	0	25	119										C	136502427	G	C	136502427	3	2	40	1	0	0	0	0	1	0	0	0	11652	1183	41	1	1053	1	PDE7B	6	136502427	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	980932	136502427	34612640	327	10000										
GPR126	57211	broad.mit.edu	37	chr6	142691518	142691518	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcagttttggaaaggccaaGagtggctactttctatccat	9	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:142691518G>C	uc010khc.2	+	4	1068	c.657G>C	c.(655-657)AAG>AAC	p.K219N	GPR126_uc010khd.2_Missense_Mutation_p.K219N|GPR126_uc010khe.2_Missense_Mutation_p.K219N|GPR126_uc010khf.2_Missense_Mutation_p.K219N|GPR126_uc003qix.2_Missense_Mutation_p.K219N	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	219	Pentaxin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		GAAAGGCCAAGAGTGGCTACT	0.388													0	0	0	0.013537	0	11	31										C	142691518	G	C	142691518	3	2	40	1	0	0	0	0	1	0	0	0	6640	933	33	1	671	1	GPR126	6	142691518	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6189091	142691518	28423549	328	10001										
PPIL4	85313	broad.mit.edu	37	chr6	149856762	149856762	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatatggtacaaagtccttgTcaacaaaggtctcattaatt	7	7	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:149856762T>C	uc003qmo.1	-	5	464	c.434A>G	c.(433-435)GAC>GGC	p.D145G	PPIL4_uc010kic.2_RNA|PPIL4_uc003qmp.1_Missense_Mutation_p.D145G	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	145	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		AAAGTCCTTGTCAACAAAGGT	0.353													0	0	0	0.004878	0	38	77										C	149856762	T	C	149856762	3	2	40	1	0	0	0	0	1	0	0	0	12329	1667	58	5	1080	5	PPIL4	6	149856762	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	7165244	149856762	21258305	329	10002										
ARID1B	57492	broad.mit.edu	37	chr6	157502230	157502230	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agagagaggctctcctgtctCaagtctgcctgccgtgggca	13	12	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:157502230C>T	uc003qqn.2	+	12	3361	c.3209C>T	c.(3208-3210)TCA>TTA	p.S1070L	ARID1B_uc003qqo.2_Missense_Mutation_p.S1030L|ARID1B_uc003qqp.2_Missense_Mutation_p.S1017L|ARID1B_uc010kjl.2_Missense_Mutation_p.S215L	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1075	ARID.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TCTCCTGTCTCAAGTCTGCCT	0.562													0	0	0	0.010504	0	19	21										T	157502230	C	T	157502230	3	4	40	1	0	0	0	0	1	0	0	0	914	838	29	1	3309	1	ARID1B	6	157502230	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7645468	157502230	13612837	330	10003										
SYNJ2	8871	broad.mit.edu	37	chr6	158499228	158499228	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accttctagacagtgatctaGatgttgacaccaaagtcaga	8	9	3	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:158499228G>C	uc003qqx.1	+	18	2557	c.2482G>C	c.(2482-2484)GAT>CAT	p.D828H	SYNJ2_uc003qqw.1_Missense_Mutation_p.D828H|SYNJ2_uc003qqy.1_Missense_Mutation_p.D541H|SYNJ2_uc003qqz.1_Missense_Mutation_p.D445H|SYNJ2_uc003qra.1_Missense_Mutation_p.D171H	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	828	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CAGTGATCTAGATGTTGACAC	0.493													0	0	0	0.010504	0	21	103										C	158499228	G	C	158499228	3	2	40	1	0	0	0	0	1	0	0	0	15450	942	33	1	2552	1	SYNJ2	6	158499228	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	996998	158499228	12615839	331	10004										
THBS2	7058	broad.mit.edu	37	chr6	169648940	169648940	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gttcaccggtgggatgtagtCaaagcgcacgaagcggtaag	15	8	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr6:169648940C>T	uc003qwt.2	-	4	429	c.181G>A	c.(181-183)GAC>AAC	p.D61N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	61	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGGATGTAGTCAAAGCGCACG	0.602													0	0	0	0.008871	0	20	26										T	169648940	C	T	169648940	3	4	40	1	0	0	0	0	1	0	0	0	15851	826	29	1	3417	1	THBS2	6	169648940	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11149712	169648940	1466127	332	10005										
LFNG	3955	broad.mit.edu	37	chr7	2565141	2565141	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacacgcgggacgtctacgtCggcaagcccagcctggacag	13	15	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:2565141C>T	uc003smf.2	+	4	692	c.675C>T	c.(673-675)GTC>GTT	p.V225V	LFNG_uc003smg.2_Silent_p.V225V	NM_001040167	NP_001035257	Q8NES3	LFNG_HUMAN	lunatic fringe isoform a	225	Lumenal (Potential).				organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		ACGTCTACGTCGGCAAGCCCA	0.677													0	0	0	0.004482	0	8	14										T	2565141	C	T	2565141	2	4	40	1	0	0	0	0	0	0	0	1	8737	871	31	1		1	LFNG	7	2565141	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		2565141	156573522	333	10006										
PMS2	5395	broad.mit.edu	37	chr7	6027006	6027006	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggtctcaggacgcctttgtCagagatggcacctgaagtgc	13	10	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:6027006C>T	uc003spl.2	-	11	1477	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N	PMS2_uc003spj.2_Missense_Mutation_p.D358N|PMS2_uc003spk.2_Missense_Mutation_p.D329N|PMS2_uc011jwl.1_Missense_Mutation_p.D329N|PMS2_uc010ktg.2_Missense_Mutation_p.D153N|PMS2_uc010kte.2_Intron|PMS2_uc010ktf.1_Missense_Mutation_p.D464N	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	464					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		ACGCCTTTGTCAGAGATGGCA	0.562			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.00874	0	45	111										T	6027006	C	T	6027006	3	4	40	1	0	0	0	0	1	0	0	0	12143	826	29	1	1218	1	PMS2	7	6027006	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3461865	6027006	153111657	334	10007										
BZW2	28969	broad.mit.edu	37	chr7	16714045	16714045	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gttttattttagatgaaaaaGagaaattcgaacccacagtc	7	6	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:16714045G>C	uc003stl.2	+	3	245	c.67G>C	c.(67-69)GAG>CAG	p.E23Q	BZW2_uc011jxx.1_5'UTR|BZW2_uc003stm.2_5'UTR|BZW2_uc003stj.2_Missense_Mutation_p.E23Q|BZW2_uc003stk.2_5'UTR|BZW2_uc003stn.1_Missense_Mutation_p.E23Q|BZW2_uc003sto.1_5'UTR|BZW2_uc003stp.2_5'UTR|BZW2_uc010kua.2_Missense_Mutation_p.E23Q	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	23					cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		AGATGAAAAAGAGAAATTCGA	0.328													0	0	0	0.007413	0	18	122										C	16714045	G	C	16714045	3	2	40	1	0	0	0	0	1	0	0	0	1579	943	33	1	73	1	BZW2	7	16714045	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10687039	16714045	142424618	335	10008										
C7orf46	340277	broad.mit.edu	37	chr7	23731113	23731113	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcaagaaagattggctcagGaaaaaccagtgggacaggac	13	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:23731113G>A	uc003swo.3	+	4	624	c.535G>A	c.(535-537)GAA>AAA	p.E179K	C7orf46_uc003swq.3_Missense_Mutation_p.E179K|C7orf46_uc003swr.3_Missense_Mutation_p.E121K|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	179											0						ATTGGCTCAGGAAAAACCAGT	0.493													0	0	0	0.01441	0	57	137										A	23731113	G	A	23731113	3	1	40	1	0	0	0	0	1	0	0	0	2396	1175	41	1	549	1	C7orf46	7	23731113	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7017068	23731113	135407550	336	10009										
TAX1BP1	8887	broad.mit.edu	37	chr7	27797748	27797748	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtcaattgtgtactagcattCcaaggtaaggactgaaaact	9	7	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:27797748C>T	uc003szl.2	+	3	419	c.261C>T	c.(259-261)TTC>TTT	p.F87F	TAX1BP1_uc011jzo.1_Silent_p.F87F|TAX1BP1_uc003szk.2_Silent_p.F87F|TAX1BP1_uc011jzp.1_5'UTR	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	87					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			TACTAGCATTCCAAGGTAAGG	0.348													0	0	0	0.008871	0	20	110										T	27797748	C	T	27797748	2	4	40	1	0	0	0	0	0	0	0	1	15591	854	30	1		1	TAX1BP1	7	27797748	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4066635	27797748	131340915	337	10010										
CHN2	1124	broad.mit.edu	37	chr7	29234571	29234571	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgcggagatggcagcgtccaGcaactccagcctgtccggct	13	15	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:29234571G>A	uc003szz.2	+	1	451	c.14G>A	c.(13-15)AGC>AAC	p.S5N	CHN2_uc011jzs.1_Intron|CHN2_uc010kva.2_Missense_Mutation_p.S5N|CHN2_uc010kvb.2_RNA|CHN2_uc010kvc.2_5'UTR|CHN2_uc011jzt.1_Missense_Mutation_p.S5N|CHN2_uc010kvd.2_Missense_Mutation_p.S5N|CHN2_uc011jzu.1_5'Flank|CPVL_uc003szx.2_Intron	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	5				MAASSN -> MRLL (in Ref. 1; AAA16836/ AAA19191).	regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						gcagcgTCCAGCAACTCCAGC	0.383													0	0	0	0.006214	0	7	18										A	29234571	G	A	29234571	3	1	40	1	0	0	0	0	1	0	0	0	3363	971	34	2	16	2	CHN2	7	29234571	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1436823	29234571	129904092	338	10011										
BMPER	168667	broad.mit.edu	37	chr7	34125385	34125385	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taggtttggaaatatcttggGatggagacagttttgtagaa	13	2	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:34125385G>C	uc011kap.1	+	13	1540	c.1426G>C	c.(1426-1428)GAT>CAT	p.D476H		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	476	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						AATATCTTGGGATGGAGACAG	0.423													0	0	0	0.00308	0	8	47										C	34125385	G	C	34125385	3	2	40	1	0	0	0	0	1	0	0	0	1468	1174	41	1	1476	1	BMPER	7	34125385	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4890814	34125385	125013278	339	10012										
TARP	445347	broad.mit.edu	37	chr7	38305062	38305062	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttttctggcaccgttaaccaGctaaatttcatgtatgtgtc	7	9	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:38305062G>C	uc003tge.1	-	5	1022	c.645C>G	c.(643-645)AGC>AGG	p.S215R	uc003tfz.1_Intron|TARP_uc003tgb.2_Missense_Mutation_p.S11R|TARP_uc003tgc.1_Missense_Mutation_p.S11R|TARP_uc003tgd.1_Missense_Mutation_p.S11R|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						CCGTTAACCAGCTAAATTTCA	0.393													0	0	0	0.01441	0	54	266										C	38305062	G	C	38305062	3	2	40	1	0	0	0	0	1	0	0	0	15555	962	34	4	314	4	TARP	7	38305062	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4179677	38305062	120833601	340	10013										
NPC1L1	29881	broad.mit.edu	37	chr7	44579102	44579102	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatcccacaagcaggatggtGaccacagcgaagacagagca	11	11	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:44579102G>A	uc003tlb.2	-	2	950	c.894C>T	c.(892-894)GTC>GTT	p.V298V	NPC1L1_uc003tlc.2_Silent_p.V298V|NPC1L1_uc011kbw.1_Silent_p.V298V|NPC1L1_uc003tld.2_Silent_p.V298V	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	298	Helical; Name=1; (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCAGGATGGTGACCACAGCGA	0.612													0	0	0	0.007413	0	20	87										A	44579102	G	A	44579102	2	1	40	1	0	0	0	0	0	0	0	1	10571	1277	45	1		1	NPC1L1	7	44579102	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6274040	44579102	114559561	341	10014										
TNS3	64759	broad.mit.edu	37	chr7	47467943	47467943	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggtgaaatgcatgtaggatGatatgaccactcctatgcgt	11	7	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:47467943G>A	uc003tnv.2	-	9	723	c.356C>T	c.(355-357)TCA>TTA	p.S119L	TNS3_uc003tnw.2_Missense_Mutation_p.S119L|TNS3_uc010kyo.1_Missense_Mutation_p.S119L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	119	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4						CATGTAGGATGATATGACCAC	0.493													0	0	0	0.00632	0	25	93										A	47467943	G	A	47467943	3	1	40	1	0	0	0	0	1	0	0	0	16341	1294	45	1	4073	1	TNS3	7	47467943	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2888841	47467943	111670720	342	10015										
SUN3	256979	broad.mit.edu	37	chr7	48046822	48046822	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttccagttgtgattattgtcCataccatccttcatatctct	4	11	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:48046822C>T	uc003tof.2	-	6	529	c.432G>A	c.(430-432)ATG>ATA	p.M144I	SUN3_uc010kyq.2_Missense_Mutation_p.M44I|SUN3_uc003tog.2_Missense_Mutation_p.M144I|SUN3_uc011kcf.1_Missense_Mutation_p.M132I	NM_152782	NP_689995	Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 1	144	Potential.					integral to membrane				central_nervous_system(1)	1						GATTATTGTCCATACCATCCT	0.483													0	0	0	0.008871	0	21	70										T	48046822	C	T	48046822	3	4	40	1	0	0	0	0	1	0	0	0	15390	594	21	2	665	2	SUN3	7	48046822	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	578879	48046822	111091841	343	10016										
ZNF713	349075	broad.mit.edu	37	chr7	56007179	56007179	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaggccttcagccacacctCatctcttagccagcctcaga	7	16	4	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:56007179C>T	uc003trc.1	+	4	811	c.773C>T	c.(772-774)TCA>TTA	p.S258L	ZNF713_uc003tra.1_Missense_Mutation_p.S271L|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGCCACACCTCATCTCTTAGC	0.423													0	0	0	0.003954	0	24	65										T	56007179	C	T	56007179	3	4	40	1	0	0	0	0	1	0	0	0	18114	838	29	1	787	1	ZNF713	7	56007179	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7960357	56007179	103131484	344	10017										
CLDN4	1364	broad.mit.edu	37	chr7	73246019	73246019	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaagcgggagatgggtgcctCgctctacgtcggctgggccg	18	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:73246019C>T	uc003tzi.3	+	1	827	c.488C>T	c.(487-489)TCG>TTG	p.S163L	RFC2_uc011kfa.1_Intron|CLDN4_uc003tzh.1_RNA	NM_001305	NP_001296	O14493	CLD4_HUMAN	claudin 4	163	Helical; (Potential).				calcium-independent cell-cell adhesion	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				ATGGGTGCCTCGCTCTACGTC	0.637													0	0	0	0.006214	0	7	28										T	73246019	C	T	73246019	3	4	40	1	0	0	0	0	1	0	0	0	3487	893	31	1	490	1	CLDN4	7	73246019	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	17238840	73246019	85892644	345	10018										
TMEM130	222865	broad.mit.edu	37	chr7	98460916	98460916	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcggtagaggtgggcgtcagCgggcagggccaggctgccgt	21	10	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:98460916C>T	uc003upo.2	-	2	382	c.193G>A	c.(193-195)GCT>ACT	p.A65T	TMEM130_uc011kiq.1_Missense_Mutation_p.A46T|TMEM130_uc011kir.1_Missense_Mutation_p.A65T|TMEM130_uc003upn.2_Intron	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	65	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGGCGTCAGCGGGCAGGGCC	0.642													0	0	0	0.00308	0	6	11										T	98460916	C	T	98460916	3	4	40	1	0	0	0	0	1	0	0	0	16040	768	27	2	1142	2	TMEM130	7	98460916	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	25214897	98460916	60677747	346	10019										
SLC26A4	5172	broad.mit.edu	37	chr7	107342406	107342406	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggaactctgagcttccagtCaaagtgaacgttcccaaagt	9	10	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:107342406C>G	uc003vep.2	+	17	2162	c.1938C>G	c.(1936-1938)GTC>GTG	p.V646V	SLC26A4_uc011kmb.1_Silent_p.V233V|SLC26A4_uc011kmc.1_Silent_p.V207V|SLC26A4_uc011kmd.1_Silent_p.V215V	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	646	STAS.|Cytoplasmic (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						AGCTTCCAGTCAAAGTGAACG	0.453									Pendred_syndrome				0	0	0	0.001855	0	14	76										G	107342406	C	G	107342406	2	3	40	1	0	0	0	0	0	0	0	1	14519	813	29	1		1	SLC26A4	7	107342406	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	8881490	107342406	51796257	347	10020										
LRRN3	54674	broad.mit.edu	37	chr7	110764893	110764893	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atctctgggaagcaggaaaaGaaaaaagtacatcactgaaa	9	6	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:110764893G>C	uc003vft.3	+	4	3111	c.2065G>C	c.(2065-2067)GAA>CAA	p.E689Q	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.E689Q|LRRN3_uc003vfs.3_Missense_Mutation_p.E689Q	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	689	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AGCAGGAAAAGAAAAAAGTAC	0.368													0	0	0	0.010729	0	11	84										C	110764893	G	C	110764893	3	2	40	1	0	0	0	0	1	0	0	0	9036	943	33	1	2067	1	LRRN3	7	110764893	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3422487	110764893	48373770	348	10021										
DOCK4	9732	broad.mit.edu	37	chr7	111634279	111634279	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcagtgggaataaccatttCaaattgtctgtgaaattaaa	7	5	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:111634279C>G	uc003vfx.2	-	5	495	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	DOCK4_uc003vfy.2_Missense_Mutation_p.E76Q|DOCK4_uc003vga.1_5'UTR|DOCK4_uc010ljt.1_Missense_Mutation_p.E76Q|DOCK4_uc003vgb.1_5'UTR	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	76					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ATAACCATTTCAAATTGTCTG	0.308													0	0	0	0.014323	0	23	89										G	111634279	C	G	111634279	3	3	40	1	0	0	0	0	1	0	0	0	4689	835	29	1	5866	1	DOCK4	7	111634279	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	869386	111634279	47504384	349	10022										
C7orf60	154743	broad.mit.edu	37	chr7	112579712	112579712	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accggagagcttctcctgctCcagtttccgctcctgctccc	8	18	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:112579712C>T	uc003vgo.1	-	1	221	c.94G>A	c.(94-96)GAG>AAG	p.E32K	C7orf60_uc011kms.1_Missense_Mutation_p.E32K	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	32										ovary(2)|skin(1)	3						TTCTCCTGCTCCAGTTTCCGC	0.647													0	0	0	0.001984	0	7	28										T	112579712	C	T	112579712	3	4	40	1	0	0	0	0	1	0	0	0	2407	864	30	1	1143	1	C7orf60	7	112579712	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	945433	112579712	46558951	350	10023										
CTTNBP2	83992	broad.mit.edu	37	chr7	117400556	117400556	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcagtggtgttattgcaagtCacgtcttccagactccacca	8	12	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:117400556C>T	uc003vjf.2	-	10	3197	c.3105G>A	c.(3103-3105)GTG>GTA	p.V1035V		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1035										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TATTGCAAGTCACGTCTTCCA	0.453													0	0	0	0.008361	0	29	180										T	117400556	C	T	117400556	2	4	40	1	0	0	0	0	0	0	0	1	4045	813	29	1		1	CTTNBP2	7	117400556	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4820844	117400556	41738107	351	10024										
ING3	54556	broad.mit.edu	37	chr7	120614801	120614801	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgccctatagaatggttccAttatggctgcgttggattga	12	7	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:120614801A>C	uc003vjn.2	+	12	1294	c.1160A>C	c.(1159-1161)CAT>CCT	p.H387P	ING3_uc003vjo.2_Missense_Mutation_p.H161P|ING3_uc003vjp.2_3'UTR|ING3_uc011kns.1_Missense_Mutation_p.H372P	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	387	PHD-type.				histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					GAATGGTTCCATTATGGCTGC	0.413													0	0	0	0.00308	0	6	53										C	120614801	A	C	120614801	3	2	40	1	0	0	0	0	1	0	0	0	7737	217	8	5	1222	5	ING3	7	120614801	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	3214245	120614801	38523862	352	10025										
PTPRZ1	5803	broad.mit.edu	37	chr7	121701184	121701184	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcagccttgtgagcacaagGcaggaagagaatccatccac	10	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:121701184G>T	uc003vjy.2	+	30	7253	c.6858G>T	c.(6856-6858)AGG>AGT	p.R2286S	PTPRZ1_uc003vjz.2_Missense_Mutation_p.R1419S|PTPRZ1_uc011knt.1_Missense_Mutation_p.R876S	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	2286	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TGAGCACAAGGCAGGAAGAGA	0.443													1	0	8.16277e-20	0.006999	8.5714e-20	41	50										T	121701184	G	T	121701184	3	4	40	1	0	0	0	0	1	0	0	0	12814	1194	42	4	6976	4	PTPRZ1	7	121701184	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1086383	121701184	37437479	353	10026										
NDUFA5	4698	broad.mit.edu	37	chr7	123197496	123197496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacagccaatcccacaaggcCagtggtctgttcaaaaacaa	7	13	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:123197496C>T	uc003vks.2	-	2	137	c.28G>A	c.(28-30)GGC>AGC	p.G10S	NDUFA5_uc003vkr.2_RNA|NDUFA5_uc003vkt.1_Missense_Mutation_p.G10S	NM_005000	NP_004991	Q16718	NDUA5_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	10					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	CCCACAAGGCCAGTGGTCTGT	0.438													0	0	0	0.010729	0	12	44										T	123197496	C	T	123197496	3	4	40	1	0	0	0	0	1	0	0	0	10268	594	21	2	338	2	NDUFA5	7	123197496	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1496312	123197496	35941167	354	10027										
SND1	27044	broad.mit.edu	37	chr7	127344995	127344995	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagaaaagctgagggcggcaGagaggtaaggtctgtccaag	16	7	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:127344995G>C	uc003vmi.2	+	8	1169	c.943G>C	c.(943-945)GAG>CAG	p.E315Q		NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	315	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GAGGGCGGCAGAGAGGTAAGG	0.532													0	0	0	0.009096	0	4	35										C	127344995	G	C	127344995	3	2	40	1	0	0	0	0	1	0	0	0	14844	943	33	1	973	1	SND1	7	127344995	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4147499	127344995	31793668	355	10028										
ZC3HC1	51530	broad.mit.edu	37	chr7	129691140	129691140	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggggtcccttctggggagcGaactactgcaccccaattct	12	13	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:129691140G>A	uc003vpi.2	-	1	94	c.67C>T	c.(67-69)CGC>TGC	p.R23C		NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	23					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					TCTGGGGAGCGAACTACTGCA	0.597													0	0	0	0.010729	0	12	69										A	129691140	G	A	129691140	3	1	40	1	0	0	0	0	1	0	0	0	17574	1058	37	1	1481	1	ZC3HC1	7	129691140	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2346145	129691140	29447523	356	10029										
DGKI	9162	broad.mit.edu	37	chr7	137075986	137075986	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaaacagcagtttccaggtCctcatggccaatgaccttat	7	12	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:137075986C>A	uc003vtt.2	-	34	3179	c.3178G>T	c.(3178-3180)GAC>TAC	p.D1060Y	DGKI_uc003vtu.2_Missense_Mutation_p.D729Y	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	1060					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTTTCCAGGTCCTCATGGCCA	0.527													1	0	2.12542e-12	0.00632	2.21335e-12	26	115										A	137075986	C	A	137075986	3	1	40	1	0	0	0	0	1	0	0	0	4471	855	30	3	23	3	DGKI	7	137075986	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7384846	137075986	22062677	357	10030										
EPHA1	2041	broad.mit.edu	37	chr7	143095738	143095738	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgaggtgctggcatggccaGagctgcccagccctgacact	13	14	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:143095738G>A	uc003wcz.2	-	6	1379	c.1292C>T	c.(1291-1293)TCT>TTT	p.S431F		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	431	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GGCATGGCCAGAGCTGCCCAG	0.572													0	0	0	0.006214	0	10	60										A	143095738	G	A	143095738	3	1	40	1	0	0	0	0	1	0	0	0	5165	942	33	1	1690	1	EPHA1	7	143095738	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6019752	143095738	16042925	358	10031										
CUL1	8454	broad.mit.edu	37	chr7	148427336	148427336	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcagagcatggccaagtccaGatatatggagctctacacgt	11	10	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:148427336G>A	uc010lpg.2	+	2	648	c.122G>A	c.(121-123)AGA>AAA	p.R41K	CUL1_uc003wey.2_Missense_Mutation_p.R41K|CUL1_uc003wez.2_5'UTR	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	41					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCCAAGTCCAGATATATGGAG	0.478													0	0	0	0.00245	0	14	89										A	148427336	G	A	148427336	3	1	40	1	0	0	0	0	1	0	0	0	4054	942	33	1	124	1	CUL1	7	148427336	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5331598	148427336	10711327	359	10032										
GIMAP8	155038	broad.mit.edu	37	chr7	150164398	150164398	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggaccctatcatgtgaacttCaaaactgaaggcagcaggtt	10	9	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr7:150164398C>T	uc003whj.2	+	2	942	c.612C>T	c.(610-612)TTC>TTT	p.F204F		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	204						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGTGAACTTCAAAACTGAAG	0.408													0	0	0	0.008871	0	20	97										T	150164398	C	T	150164398	2	4	40	1	0	0	0	0	0	0	0	1	6385	825	29	1		1	GIMAP8	7	150164398	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1737062	150164398	8974265	360	10033										
CLN8	2055	broad.mit.edu	37	chr8	1728467	1728467	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaaccagtggctgatgattCacatgtttcactgccgcatg	9	11	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:1728467C>T	uc003wpo.3	+	3	900	c.595C>T	c.(595-597)CAC>TAC	p.H199Y		NM_018941	NP_061764	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8	199	TLC.				cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		GCTGATGATTCACATGTTTCA	0.517													0	0	0	0.013537	0	11	72										T	1728467	C	T	1728467	3	4	40	1	0	0	0	0	1	0	0	0	3546	826	29	1	601	1	CLN8	8	1728467	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		1728467	144635555	361	10034										
ARHGEF10	9639	broad.mit.edu	37	chr8	1876813	1876813	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgtgtagggacggaggaggGaaggtagggcatgctcactg	19	6	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:1876813G>A	uc003wpr.2	+	24	3096	c.2918G>A	c.(2917-2919)GGA>GAA	p.G973E	ARHGEF10_uc003wps.2_Missense_Mutation_p.G935E|ARHGEF10_uc010lre.2_Missense_Mutation_p.G624E	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	998					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		ACGGAGGAGGGAAGGTAGGGC	0.617													0	0	0	0.001984	0	5	37										A	1876813	G	A	1876813	3	1	40	1	0	0	0	0	1	0	0	0	894	1174	41	1	3008	1	ARHGEF10	8	1876813	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	148346	1876813	144487209	362	10035										
DLC1	10395	broad.mit.edu	37	chr8	12947971	12947971	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttacgacatcggctcatttcCtcgggaacctgtgcggaaca	10	12	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:12947971C>T	uc003wwm.2	-	15	4308	c.3864G>A	c.(3862-3864)GAG>GAA	p.E1288E	DLC1_uc003wwk.1_Silent_p.E851E|DLC1_uc003wwl.1_Silent_p.E885E|DLC1_uc011kxx.1_Silent_p.E777E	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1288					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GGCTCATTTCCTCGGGAACCT	0.517													0	0	0	0.013537	0	12	47										T	12947971	C	T	12947971	2	4	40	1	0	0	0	0	0	0	0	1	4550	680	24	2		2	DLC1	8	12947971	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11071158	12947971	133416051	363	10036										
PSD3	23362	broad.mit.edu	37	chr8	18729854	18729854	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgttttacgactggcagtgtCcagctctttttccacctgct	8	12	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:18729854C>T	uc003wza.2	-	3	623	c.520G>A	c.(520-522)GAC>AAC	p.D174N		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	174					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTGGCAGTGTCCAGCTCTTTT	0.443													0	0	0	0.009535	0	21	118										T	18729854	C	T	18729854	3	4	40	1	0	0	0	0	1	0	0	0	12648	855	30	1	2715	1	PSD3	8	18729854	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5781883	18729854	127634168	364	10037										
CSGALNACT1	55790	broad.mit.edu	37	chr8	19316071	19316071	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgaatggtcgaaataagatGagccgtttgaattcgtgttt	11	6	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:19316071G>T	uc011kyn.1	-	5	1781	c.717C>A	c.(715-717)CTC>CTA	p.L239L	CSGALNACT1_uc011kyo.1_Silent_p.L239L|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Silent_p.L238L|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	239	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GAAATAAGATGAGCCGTTTGA	0.433													1	0	1.87469e-40	0.01441	1.99469e-40	61	200										T	19316071	G	T	19316071	2	4	40	1	0	0	0	0	0	0	0	1	3938	1277	45	3		3	CSGALNACT1	8	19316071	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	586217	19316071	127047951	365	10038										
REEP4	80346	broad.mit.edu	37	chr8	21997685	21997685	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcggaccctgcgtccatacCaggagataaaaatgtctgta	10	10	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:21997685C>T	uc003xau.1	-	3	635	c.182G>A	c.(181-183)TGG>TAG	p.W61*	REEP4_uc010ltt.1_Nonsense_Mutation_p.W61*|REEP4_uc011kyz.1_Nonsense_Mutation_p.W61*	NM_025232	NP_079508	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	61	Helical; (Potential).					integral to membrane				skin(1)	1				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		GCGTCCATACCAGGAGATAAA	0.577													0	0	0	0.000602	0	4	15										T	21997685	C	T	21997685	4	4	40	1	0	0	0	0	0	1	0	0	13207	608	21	2	615	2	REEP4	8	21997685	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2681614	21997685	124366337	366	10039										
EGR3	1960	broad.mit.edu	37	chr8	22548114	22548114	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcgtggcgcttgcgctcgtCgctgcgcgcaaacttgcgcc	15	15	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:22548114C>G	uc003xcm.1	-	2	1394	c.1036G>C	c.(1036-1038)GAC>CAC	p.D346H	EGR3_uc011kzn.1_Missense_Mutation_p.D308H|EGR3_uc011kzo.1_Missense_Mutation_p.D292H	NM_004430	NP_004421	Q06889	EGR3_HUMAN	early growth response 3	346	C2H2-type 3.				circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)		TTGCGCTCGTCGCTGCGCGCA	0.647													0	0	0	0.003163	0	11	39										G	22548114	C	G	22548114	3	3	40	1	0	0	0	0	1	0	0	0	4973	884	31	1	131	1	EGR3	8	22548114	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	550429	22548114	123815908	367	10040										
GTF2E2	2961	broad.mit.edu	37	chr8	30472223	30472223	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggatgcgtatctcctcgctGatgccgtgtctatcaagtga	11	10	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:30472223G>A	uc003xig.2	-	4	521	c.268C>T	c.(268-270)CAG>TAG	p.Q90*		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	90	TFIIE beta.				regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		TCTCCTCGCTGATGCCGTGTC	0.358													0	0	0	0.010504	0	21	73										A	30472223	G	A	30472223	4	1	40	1	0	0	0	0	0	1	0	0	6857	1299	45	1	627	1	GTF2E2	8	30472223	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7924109	30472223	115891799	368	10041										
DDHD2	23259	broad.mit.edu	37	chr8	38090714	38090714	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgaggattcacagcagctgGaagaggcatatagctctggt	13	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:38090714G>A	uc003xlb.2	+	2	579	c.202G>A	c.(202-204)GAA>AAA	p.E68K	DDHD2_uc003xla.2_Missense_Mutation_p.E68K|DDHD2_uc003xlc.2_Missense_Mutation_p.E68K|DDHD2_uc011lbl.1_5'UTR	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	68	WWE.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			ACAGCAGCTGGAAGAGGCATA	0.388													0	0	0	0.006122	0	18	76										A	38090714	G	A	38090714	3	1	40	1	0	0	0	0	1	0	0	0	4327	1175	41	1	204	1	DDHD2	8	38090714	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7618491	38090714	108273308	369	10042										
MCM4	4173	broad.mit.edu	37	chr8	48888324	48888324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaagaattagctgaagcattGaaaaagcttattttatctaa	7	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:48888324G>C	uc003xqk.1	+	16	2510	c.2415G>C	c.(2413-2415)TTG>TTC	p.L805F	MCM4_uc003xql.1_Missense_Mutation_p.L805F|MCM4_uc011ldi.1_Missense_Mutation_p.L792F	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	805					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				CTGAAGCATTGAAAAAGCTTA	0.328													0	0	0	0.013537	0	13	58										C	48888324	G	C	48888324	3	2	40	1	0	0	0	0	1	0	0	0	9389	1281	45	1	2473	1	MCM4	8	48888324	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10797610	48888324	97475698	370	10043										
CHD7	55636	broad.mit.edu	37	chr8	61748694	61748694	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgcagagtctccagattttCagctccaggcaatgatccag	9	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:61748694C>T	uc003xue.2	+	16	4318	c.3841C>T	c.(3841-3843)CAG>TAG	p.Q1281*		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1281					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCCAGATTTTCAGCTCCAGGC	0.458													0	0	0	0.001855	0	14	13										T	61748694	C	T	61748694	4	4	40	1	0	0	0	0	0	1	0	0	3330	827	29	1	3899	1	CHD7	8	61748694	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	12860370	61748694	84615328	371	10044										
ZFHX4	79776	broad.mit.edu	37	chr8	77618332	77618332	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaggagaaacaccctgagcCgggtggctcttgtgtttatt	13	8	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:77618332C>T	uc003yav.2	+	2	2396	c.2009C>T	c.(2008-2010)CCG>CTG	p.P670L	ZFHX4_uc003yat.1_Missense_Mutation_p.P670L|ZFHX4_uc003yau.1_Missense_Mutation_p.P670L|ZFHX4_uc003yaw.1_Missense_Mutation_p.P670L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	670						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCCTGAGCCGGGTGGCTCT	0.507										HNSCC(33;0.089)			0	0	0	0.001168	0	5	39										T	77618332	C	T	77618332	3	4	40	1	0	0	0	0	1	0	0	0	17632	652	23	2	2011	2	ZFHX4	8	77618332	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	15869638	77618332	68745690	372	10045										
MMP16	4325	broad.mit.edu	37	chr8	89179976	89179976	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccaattcctggtccagggaAgtaggcatgtgccaaaaatc	10	10	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:89179976A>G	uc003yeb.3	-	4	913	c.631T>C	c.(631-633)TTC>CTC	p.F211L	MMP16_uc003yec.2_Missense_Mutation_p.F211L	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	211	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						GGTCCAGGGAAGTAGGCATGT	0.438													0	0	0	0.008871	0	19	102										G	89179976	A	G	89179976	3	3	40	1	0	0	0	0	1	0	0	0	9655	72	3	5	1376	5	MMP16	8	89179976	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	11561644	89179976	57184046	373	10046										
NBN	4683	broad.mit.edu	37	chr8	90955531	90955531	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctgtattctttcgagcatGatgagctattagatctgatc	8	7	3	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:90955531G>A	uc003yej.1	-	14	2244	c.2134C>T	c.(2134-2136)CAT>TAT	p.H712Y	NBN_uc003yei.1_Missense_Mutation_p.H630Y|NBN_uc011lgb.1_Missense_Mutation_p.H712Y	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	712					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TTTCGAGCATGATGAGCTATT	0.393								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.01441	0	114	87										A	90955531	G	A	90955531	3	1	40	1	0	0	0	0	1	0	0	0	10191	1290	45	1	142	1	NBN	8	90955531	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1775555	90955531	55408491	374	10047										
ESRP1	54845	broad.mit.edu	37	chr8	95653664	95653664	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgttctggaaagtcgtggatCtggccaacaagaaggtattt	12	6	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:95653664C>T	uc003ygq.3	+	1	301	c.118C>T	c.(118-120)CTG>TTG	p.L40L	ESRP1_uc003ygr.3_Silent_p.L40L|ESRP1_uc003ygs.3_Silent_p.L40L|ESRP1_uc003ygt.3_Silent_p.L40L|ESRP1_uc003ygu.3_Silent_p.L40L	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	40					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						AGTCGTGGATCTGGCCAACAA	0.527													0	0	0	0.01441	0	46	37										T	95653664	C	T	95653664	2	4	40	1	0	0	0	0	0	0	0	1	5258	912	32	1		1	ESRP1	8	95653664	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4698133	95653664	50710358	375	10048										
TMEM74	157753	broad.mit.edu	37	chr8	109797208	109797208	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcacactgtttctgacagcaGagagcagctcttgtggctgc	12	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:109797208G>C	uc003ymy.1	-	2	225	c.120C>G	c.(118-120)CTC>CTG	p.L40L	TMEM74_uc003ymx.2_Intron	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	transmembrane protein 74	40					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			TCTGACAGCAGAGAGCAGCTC	0.542													0	0	0	0.007413	0	18	121										C	109797208	G	C	109797208	2	2	40	1	0	0	0	0	0	0	0	1	16199	929	33	1		1	TMEM74	8	109797208	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	14143544	109797208	36566814	376	10049										
ANXA13	312	broad.mit.edu	37	chr8	124693585	124693585	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcttggaactttgctttgatCccctgaaggtccacctgtag	9	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:124693585C>T	uc003yqu.2	-	11	919	c.846G>A	c.(844-846)GGG>GGA	p.G282G	ANXA13_uc003yqt.2_Silent_p.G323G	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a	282	Annexin 4.				cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			TTGCTTTGATCCCCTGAAGGT	0.343													0	0	0	0.01441	0	140	129										T	124693585	C	T	124693585	2	4	40	1	0	0	0	0	0	0	0	1	717	842	30	1		1	ANXA13	8	124693585	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	14896377	124693585	21670437	377	10050										
COL22A1	169044	broad.mit.edu	37	chr8	139629181	139629181	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggaccgggtgcaccagaatcGcctgtgtgtcccttgaagcc	13	13	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:139629181G>A	uc003yvd.2	-	54	4293	c.3846C>T	c.(3844-3846)GGC>GGT	p.G1282G	COL22A1_uc011ljo.1_Silent_p.G562G	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1282	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CACCAGAATCGCCTGTGTGTC	0.587										HNSCC(7;0.00092)			0	0	0	0.01441	0	64	37										A	139629181	G	A	139629181	2	1	40	1	0	0	0	0	0	0	0	1	3681	1074	38	2		2	COL22A1	8	139629181	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	14935596	139629181	6734841	378	10051										
CPSF1	29894	broad.mit.edu	37	chr8	145622704	145622704	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgcagggcaccacctacctCcatggtgccattctcccgca	9	17	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:145622704C>T	uc003zcj.2	-	22	2458	c.2383G>A	c.(2383-2385)GAG>AAG	p.E795K		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	795					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCACCTACCTCCATGGTGCCA	0.682													0	0	0	0.010729	0	12	9										T	145622704	C	T	145622704	3	4	40	1	0	0	0	0	1	0	0	0	3824	864	30	1	2016	1	CPSF1	8	145622704	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5993523	145622704	741318	379	10052										
ZNF7	7553	broad.mit.edu	37	chr8	146068042	146068042	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagccttatttaccatcagaGaatccataaaggagagaagc	8	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:146068042G>A	uc003zeg.3	+	5	1687	c.1550G>A	c.(1549-1551)AGA>AAA	p.R517K	ZNF7_uc010mge.2_Missense_Mutation_p.R528K|ZNF7_uc011lln.1_Missense_Mutation_p.R421K|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.R421K|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	517	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TACCATCAGAGAATCCATAAA	0.453													0	0	0	0.001855	0	14	102										A	146068042	G	A	146068042	3	1	40	1	0	0	0	0	1	0	0	0	18099	942	33	1	1564	1	ZNF7	8	146068042	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	445338	146068042	295980	380	10053										
C8orf33	65265	broad.mit.edu	37	chr8	146279413	146279413	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccccgacagctgcttattCagcccaggtgcaacctgtag	9	15	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr8:146279413C>G	uc003zfc.3	+	5	614	c.560C>G	c.(559-561)TCA>TGA	p.S187*	C8orf33_uc003zfd.2_RNA	NM_023080	NP_075568	Q9H7E9	CH033_HUMAN	hypothetical protein LOC65265	187											0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GCTGCTTATTCAGCCCAGGTG	0.393													0	0	0	0.01441	0	160	148										G	146279413	C	G	146279413	4	3	40	1	0	0	0	0	0	1	0	0	2421	838	29	1	578	1	C8orf33	8	146279413	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	211371	146279413	84609	381	10054										
DOCK8	81704	broad.mit.edu	37	chr9	422091	422091	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatgaaaatttgagatggaaGaaagagcagacacattggcg	12	4	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:422091G>A	uc003zgf.2	+	33	4309	c.4197G>A	c.(4195-4197)AAG>AAA	p.K1399K	DOCK8_uc010mgu.2_Silent_p.K701K|DOCK8_uc010mgv.2_Silent_p.K1299K|DOCK8_uc003zgk.2_Silent_p.K857K	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1399	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TGAGATGGAAGAAAGAGCAGA	0.398													0	0	0	0.012319	0	17	24										A	422091	G	A	422091	2	1	40	1	0	0	0	0	0	0	0	1	4693	933	33	1		1	DOCK8	9	422091	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		422091	140791340	382	10055										
DOCK8	81704	broad.mit.edu	37	chr9	429848	429848	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgaggttcagttttggagcCaccagtgtaagagttcaaac	11	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:429848C>T	uc003zgf.2	+	36	4732	c.4620C>T	c.(4618-4620)GCC>GCT	p.A1540A	DOCK8_uc010mgu.2_Silent_p.A842A|DOCK8_uc010mgv.2_Silent_p.A1440A|DOCK8_uc003zgk.2_Silent_p.A998A	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1540	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GTTTTGGAGCCACCAGTGTAA	0.468													0	0	0	0.00499	0	18	27										T	429848	C	T	429848	2	4	40	1	0	0	0	0	0	0	0	1	4693	581	21	2		2	DOCK8	9	429848	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7757	429848	140783583	383	10056										
RFK	55312	broad.mit.edu	37	chr9	79002362	79002362	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agaaacctggaagaaattgtCttctttgattttcaaatgtt	7	5	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:79002362C>T	uc004akd.2	-	4	778	c.442G>A	c.(442-444)GAC>AAC	p.D148N	RFK_uc004ake.2_3'UTR	NM_018339	NP_060809	Q969G6	RIFK_HUMAN	riboflavin kinase	141					riboflavin biosynthetic process	cytosol	ATP binding|metal ion binding|riboflavin kinase activity				0					Riboflavin(DB00140)	AAGAAATTGTCTTCTTTGATT	0.313													0	0	0	0.01441	0	70	108										T	79002362	C	T	79002362	3	4	40	1	0	0	0	0	1	0	0	0	13251	913	32	1	50	1	RFK	9	79002362	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	78572514	79002362	62211069	384	10057										
FAM22F	54754	broad.mit.edu	37	chr9	97082700	97082700	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaggggggatctcctcaggGaccttggtctccgctggcct	14	13	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:97082700G>C	uc004aup.1	-	5	1179	c.1158C>G	c.(1156-1158)GTC>GTG	p.V386V		NM_017561	NP_060031	A1L443	FA22F_HUMAN	hypothetical protein LOC54754	386	Pro-rich.										0		Acute lymphoblastic leukemia(62;0.136)				TCTCCTCAGGGACCTTGGTCT	0.667													0	0	0	0.013726	0	30	40										C	97082700	G	C	97082700	2	2	40	1	0	0	0	0	0	0	0	1	5545	1161	41	1		1	FAM22F	9	97082700	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	18080338	97082700	44130731	385	10058										
SNX30	401548	broad.mit.edu	37	chr9	115598511	115598511	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caggacctgaacgcctacaaGaagcaagggatagcattgct	11	10	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:115598511G>A	uc004bgj.3	+	5	784	c.636G>A	c.(634-636)AAG>AAA	p.K212K	SNX30_uc004bgi.3_5'Flank	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	212					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						ACGCCTACAAGAAGCAAGGGA	0.498													0	0	0	0.012319	0	23	163										A	115598511	G	A	115598511	2	1	40	1	0	0	0	0	0	0	0	1	14900	933	33	1		1	SNX30	9	115598511	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	18515811	115598511	25614920	386	10059										
ZFP37	7539	broad.mit.edu	37	chr9	115805331	115805331	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatttgtttaaagcctttccCacattgattacattcaaagg	5	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:115805331C>G	uc004bgm.1	-	4	1595	c.1567G>C	c.(1567-1569)GGG>CGG	p.G523R	ZFP37_uc011lwz.1_Missense_Mutation_p.G538R|ZFP37_uc011lxa.1_Missense_Mutation_p.G524R	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	523	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AAGCCTTTCCCACATTGATTA	0.388													0	0	0	0.005524	0	39	77										G	115805331	C	G	115805331	3	3	40	1	0	0	0	0	1	0	0	0	17645	594	21	4	329	4	ZFP37	9	115805331	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	206820	115805331	25408100	387	10060										
COL27A1	85301	broad.mit.edu	37	chr9	117027210	117027210	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctgcttcccacagggccctCcaggaccccagggcagaccg	11	18	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:117027210C>G	uc011lxl.1	+	30	3256	c.3256C>G	c.(3256-3258)CCA>GCA	p.P1086A	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1086	Pro-rich.|Collagen-like 8.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ACAGGGCCCTCCAGGACCCCA	0.612													0	0	0	0.010771	0	39	42										G	117027210	C	G	117027210	3	3	40	1	0	0	0	0	1	0	0	0	3685	855	30	1	3374	1	COL27A1	9	117027210	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1221879	117027210	24186221	388	10061										
FAM125B	89853	broad.mit.edu	37	chr9	129157918	129157918	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caagaaatcatgactcatctCaacccacaacgccttcccag	4	16	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:129157918C>T	uc004bqh.1	+	6	685	c.604C>T	c.(604-606)CAA>TAA	p.Q202*	FAM125B_uc004bqg.1_Nonsense_Mutation_p.Q202*|FAM125B_uc011lzy.1_Nonsense_Mutation_p.Q187*|FAM125B_uc010mxd.2_Nonsense_Mutation_p.Q195*|FAM125B_uc011lzz.1_Nonsense_Mutation_p.Q195*	NM_033446	NP_258257	Q9H7P6	F125B_HUMAN	hypothetical protein LOC89853 isoform 1	202					protein transport	late endosome membrane					0						TGACTCATCTCAACCCACAAC	0.522													0	0	0	0.004656	0	26	143										T	129157918	C	T	129157918	4	4	40	1	0	0	0	0	0	1	0	0	5428	827	29	1	626	1	FAM125B	9	129157918	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	12130708	129157918	12055513	389	10062										
RALGPS1	9649	broad.mit.edu	37	chr9	129958857	129958857	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctagagtcccgcagcccccGaaggggcctggctctgacct	12	17	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:129958857G>A	uc004bqo.1	+	13	1409	c.1142G>A	c.(1141-1143)CGA>CAA	p.R381Q	RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	381					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						CGCAGCCCCCGAAGGGGCCTG	0.577													0	0	0	0.01441	0	61	47										A	129958857	G	A	129958857	3	1	40	1	0	0	0	0	1	0	0	0	13017	1058	37	1	1188	1	RALGPS1	9	129958857	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	800939	129958857	11254574	390	10063										
CRAT	1384	broad.mit.edu	37	chr9	131864290	131864290	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctgcacaaagatctgatccGcagtgaggggtgtcccgtca	13	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:131864290G>A	uc004bxh.2	-	6	959	c.677C>T	c.(676-678)GCG>GTG	p.A226V	CRAT_uc004bxg.2_Missense_Mutation_p.A205V|CRAT_uc004bxk.3_Missense_Mutation_p.A205V	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	226					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	GATCTGATCCGCAGTGAGGGG	0.567													0	0	0	0.009096	0	4	38										A	131864290	G	A	131864290	3	1	40	1	0	0	0	0	1	0	0	0	3847	1087	38	2	1239	2	CRAT	9	131864290	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1905433	131864290	9349141	391	10064										
ABL1	25	broad.mit.edu	37	chr9	133760298	133760298	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggccccgccgaggagtccaGagtgaggaggcacaagcact	16	12	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:133760298G>A	uc004bzw.2	+	11	2624	c.2621G>A	c.(2620-2622)AGA>AAA	p.R874K	ABL1_uc004bzv.2_Missense_Mutation_p.R893K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	874	DNA-binding (By similarity).|Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GAGGAGTCCAGAGTGAGGAGG	0.667			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.001984	0	5	12										A	133760298	G	A	133760298	3	1	40	1	0	0	0	0	1	0	0	0	92	942	33	1	2803	1	ABL1	9	133760298	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1896008	133760298	7453133	392	10065										
RAPGEF1	2889	broad.mit.edu	37	chr9	134454941	134454941	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgttcctgggtttaattttCagagacagttcccatagggc	10	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:134454941C>G	uc004cbc.2	-	24	3307	c.3177G>C	c.(3175-3177)CTG>CTC	p.L1059L	RAPGEF1_uc004cbb.2_Silent_p.L1077L	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	1059	Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GTTTAATTTTCAGAGACAGTT	0.517													0	0	0	0.003271	0	34	148										G	134454941	C	G	134454941	2	3	40	1	0	0	0	0	0	0	0	1	13043	813	29	1		1	RAPGEF1	9	134454941	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	694643	134454941	6758490	393	10066										
MED27	9442	broad.mit.edu	37	chr9	134952861	134952861	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttatatgcttgaaggagttGactatagagaggagttttgt	12	3	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:134952861G>C	uc004cbe.1	-	2	338	c.316C>G	c.(316-318)CAA>GAA	p.Q106E	MED27_uc004cbf.1_Missense_Mutation_p.Q106E|MED27_uc011mco.1_Missense_Mutation_p.Q106E|MED27_uc004cbg.3_Missense_Mutation_p.Q106E	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	106					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		TGAAGGAGTTGACTATAGAGA	0.418													0	0	0	0.01441	0	43	213										C	134952861	G	C	134952861	3	2	40	1	0	0	0	0	1	0	0	0	9445	1299	45	1	647	1	MED27	9	134952861	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	497920	134952861	6260570	394	10067										
TSC1	7248	broad.mit.edu	37	chr9	135781419	135781419	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgccgagtgggtcttccgctGagaacctgggagactgtctc	14	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:135781419G>A	uc004cca.2	-	15	1780	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	TSC1_uc004ccb.3_Nonsense_Mutation_p.Q515*|TSC1_uc011mcq.1_Nonsense_Mutation_p.Q465*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	516					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GTCTTCCGCTGAGAACCTGGG	0.567			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.010504	0	21	19										A	135781419	G	A	135781419	4	1	40	1	0	0	0	0	0	1	0	0	16602	1299	45	1	1984	1	TSC1	9	135781419	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	828558	135781419	5432012	395	10068										
FCN2	2220	broad.mit.edu	37	chr9	137777709	137777709	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggctgggggagttctggctGgggaatgacaacatccacgc	16	10	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:137777709G>A	uc004cfg.1	+	6	535	c.525G>A	c.(523-525)CTG>CTA	p.L175L	FCN2_uc004cfh.1_Silent_p.L137L	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	175	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		AGTTCTGGCTGGGGAATGACA	0.672													0	0	0	0.004656	0	26	24										A	137777709	G	A	137777709	2	1	40	1	0	0	0	0	0	0	0	1	5792	1335	47	2		2	FCN2	9	137777709	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1996290	137777709	3435722	396	10069										
FCN1	2219	broad.mit.edu	37	chr9	137804336	137804336	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acggcagtggccctaccctgGgcagtcagggcgtggatgtt	16	11	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr9:137804336G>C	uc004cfi.2	-	7	686	c.594C>G	c.(592-594)GCC>GCG	p.A198A		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	198	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CCCTACCCTGGGCAGTCAGGG	0.642													0	0	0	0.001168	0	4	13										C	137804336	G	C	137804336	2	2	40	1	0	0	0	0	0	0	0	1	5791	1219	43	4		4	FCN1	9	137804336	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	26627	137804336	3409095	397	10070										
SLC39A12	221074	broad.mit.edu	37	chr10	18331702	18331702	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcctgcaaaactttggattGatcctaggttggctttctct	8	10	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:18331702G>C	uc001ipo.2	+	13	2289	c.2016G>C	c.(2014-2016)TTG>TTC	p.L672F	SLC39A12_uc001ipn.2_Missense_Mutation_p.L635F|SLC39A12_uc001ipp.2_Missense_Mutation_p.L671F|SLC39A12_uc010qck.1_Missense_Mutation_p.L538F	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	672	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						ACTTTGGATTGATCCTAGGTT	0.338													0	0	0	0.003755	0	35	186										C	18331702	G	C	18331702	3	2	40	1	0	0	0	0	1	0	0	0	14615	1281	45	1	2062	1	SLC39A12	10	18331702	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		18331702	117203045	398	10071										
CUL2	8453	broad.mit.edu	37	chr10	35317794	35317794	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaacgtagatgaaggagcctGagtaagaggccacgcaccag	13	9	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:35317794G>A	uc001ixv.2	-	16	1771	c.1561C>T	c.(1561-1563)CAG>TAG	p.Q521*	CUL2_uc009xma.2_Nonsense_Mutation_p.Q390*|CUL2_uc010qer.1_Nonsense_Mutation_p.Q540*|CUL2_uc001ixw.2_Nonsense_Mutation_p.Q521*|CUL2_uc010qes.1_Nonsense_Mutation_p.Q458*	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	521					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						GAAGGAGCCTGAGTAAGAGGC	0.308													0	0	0	0.008871	0	19	35										A	35317794	G	A	35317794	4	1	40	1	0	0	0	0	0	1	0	0	4055	1299	45	1	700	1	CUL2	10	35317794	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	16986092	35317794	100216953	399	10072										
FZD8	8325	broad.mit.edu	37	chr10	35929518	35929518	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcaccgaccacaggccgatCcagaagacggtgaaggcgcg	14	13	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:35929518C>G	uc001iyz.1	-	1	845	c.840G>C	c.(838-840)TGG>TGC	p.W280C		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	280	Helical; Name=1; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						ACAGGCCGATCCAGAAGACGG	0.612													0	0	0	0.004672	0	3	45										G	35929518	C	G	35929518	3	3	40	1	0	0	0	0	1	0	0	0	6136	856	30	1	1248	1	FZD8	10	35929518	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	611724	35929518	99605229	400	10073										
HNRNPF	3185	broad.mit.edu	37	chr10	43883236	43883236	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccatcatgaatcgtgcagtCagagaggaagttctgcacgt	11	10	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:43883236C>T	uc009xmh.1	-	3	584	c.97G>A	c.(97-99)GAC>AAC	p.D33N	HNRNPF_uc001jar.2_Missense_Mutation_p.D33N|HNRNPF_uc001jas.2_Missense_Mutation_p.D33N|HNRNPF_uc001jat.2_Missense_Mutation_p.D33N|HNRNPF_uc001jav.2_Missense_Mutation_p.D33N|HNRNPF_uc001jau.2_Missense_Mutation_p.D33N	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	33	RRM 1.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						ATCGTGCAGTCAGAGAGGAAG	0.552													0	0	0	0.007413	0	20	79										T	43883236	C	T	43883236	3	4	40	1	0	0	0	0	1	0	0	0	7265	826	29	1	1154	1	HNRNPF	10	43883236	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7953718	43883236	91651511	401	10074										
ZNF239	8187	broad.mit.edu	37	chr10	44052855	44052855	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctgtgtggtctctctgatGaagtagtagctctgagcttt	11	7	4	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:44052855G>A	uc001jaw.3	-	2	1326	c.673C>T	c.(673-675)CAT>TAT	p.H225Y	ZNF239_uc001jax.3_Missense_Mutation_p.H225Y|ZNF239_uc009xmj.2_Missense_Mutation_p.H225Y|ZNF239_uc009xmk.2_Missense_Mutation_p.H225Y	NM_005674	NP_005665	Q16600	ZN239_HUMAN	zinc finger protein 239	225	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding				0						TCTCTCTGATGAAGTAGTAGC	0.458													0	0	0	0.005443	0	28	223										A	44052855	G	A	44052855	3	1	40	1	0	0	0	0	1	0	0	0	17788	1290	45	1	707	1	ZNF239	10	44052855	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	169619	44052855	91481892	402	10075										
FRMPD2	143162	broad.mit.edu	37	chr10	49450206	49450206	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcacggttctctactgacctCagaaatggtacccagaacca	8	13	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:49450206C>T	uc001jgi.2	-	5	672	c.565G>A	c.(565-567)GAG>AAG	p.E189K	FRMPD2_uc001jgh.2_Missense_Mutation_p.E158K|FRMPD2_uc001jgj.2_Missense_Mutation_p.E167K	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	189	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTACTGACCTCAGAAATGGTA	0.299													0	0	0	0.008871	0	19	139										T	49450206	C	T	49450206	3	4	40	1	0	0	0	0	1	0	0	0	6058	835	29	1	3464	1	FRMPD2	10	49450206	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5397351	49450206	86084541	403	10076										
BICC1	80114	broad.mit.edu	37	chr10	60273078	60273078	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcgtggacaggaagaaacttGaggccatgttacaaggtagg	15	6	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:60273078G>A	uc001jki.1	+	1	175	c.175G>A	c.(175-177)GAG>AAG	p.E59K		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	59					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GAAGAAACTTGAGGCCATGTT	0.657													0	0	0	0.012319	0	20	34										A	60273078	G	A	60273078	3	1	40	1	0	0	0	0	1	0	0	0	1427	1291	45	1	177	1	BICC1	10	60273078	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10822872	60273078	75261669	404	10077										
HK1	3098	broad.mit.edu	37	chr10	71144211	71144211	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agatctacgccattcctattGaaatcatgcagggcactggg	10	10	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:71144211G>A	uc001jpl.3	+	11	1794	c.1693G>A	c.(1693-1695)GAA>AAA	p.E565K	HK1_uc001jpg.3_Missense_Mutation_p.E553K|HK1_uc001jph.3_Missense_Mutation_p.E569K|HK1_uc001jpi.3_Missense_Mutation_p.E569K|HK1_uc001jpj.3_Missense_Mutation_p.E600K|HK1_uc001jpk.3_Missense_Mutation_p.E564K|HK1_uc009xqd.2_Missense_Mutation_p.E443K	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	565	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						CATTCCTATTGAAATCATGCA	0.498													0	0	0	0.013726	0	34	91										A	71144211	G	A	71144211	3	1	40	1	0	0	0	0	1	0	0	0	7190	1291	45	1	1913	1	HK1	10	71144211	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10871133	71144211	64390536	405	10078										
PRF1	5551	broad.mit.edu	37	chr10	72358051	72358051	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacctgcaacctcaggggccCccctgtggccaggagcacat	12	16	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:72358051C>T	uc009xqg.2	-	3	1587	c.1426G>A	c.(1426-1428)GGG>AGG	p.G476R	PRF1_uc001jrf.3_Missense_Mutation_p.G476R	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	476	C2.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CTCAGGGGCCCCCCTGTGGCC	0.607			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.008361	0	29	82										T	72358051	C	T	72358051	3	4	40	1	0	0	0	0	1	0	0	0	12478	623	22	2	245	2	PRF1	10	72358051	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1213840	72358051	63176696	406	10079										
CAMK2G	818	broad.mit.edu	37	chr10	75609037	75609037	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accttcaggtccctgtggacGatgtcatgctggtggatgtg	14	9	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:75609037G>A	uc001jvv.1	-	6	496	c.372C>T	c.(370-372)ATC>ATT	p.I124I	CAMK2G_uc001jvm.1_Silent_p.I132I|CAMK2G_uc001jvo.1_Silent_p.I132I|CAMK2G_uc001jvq.1_Silent_p.I132I|CAMK2G_uc001jvr.1_Silent_p.I132I|CAMK2G_uc001jvp.1_Silent_p.I132I|CAMK2G_uc001jvs.1_Silent_p.I132I|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Silent_p.I110I|CAMK2G_uc010qkv.1_Intron	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	132	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CCCTGTGGACGATGTCATGCT	0.522											OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	6	23										A	75609037	G	A	75609037	2	1	40	1	0	0	0	0	0	0	0	1	2602	1048	37	1		1	CAMK2G	10	75609037	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3250986	75609037	59925710	407	10080										
BTAF1	9044	broad.mit.edu	37	chr10	93719635	93719635	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttggagactttgtttctgatGaagtaagtatcatttaaggg	11	3	2	3	rs112687582		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:93719635G>A	uc001khr.2	+	10	1182	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	BTAF1_uc009xua.1_RNA|BTAF1_uc001khs.1_Missense_Mutation_p.E32K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	362					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TGTTTCTGATGAAGTAAGTAT	0.348													0	0	0	0.007835	0	41	80										A	93719635	G	A	93719635	3	1	40	1	0	0	0	0	1	0	0	0	1536	1291	45	1	1122	1	BTAF1	10	93719635	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	18110598	93719635	41815112	408	10081										
IDE	3416	broad.mit.edu	37	chr10	94267358	94267358	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcttggaaaacccattcttGaggtccttctgcacgtaact	7	12	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:94267358G>C	uc001kia.2	-	9	1295	c.1219C>G	c.(1219-1221)CAA>GAA	p.Q407E		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	407					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACCCATTCTTGAGGTCCTTCT	0.328													0	0	0	0.013726	0	33	172										C	94267358	G	C	94267358	3	2	40	1	0	0	0	0	1	0	0	0	7493	1299	45	1	1908	1	IDE	10	94267358	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	547723	94267358	41267389	409	10082										
EXOC6	54536	broad.mit.edu	37	chr10	94757311	94757311	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagatgctactggacagtgaGttaaaacaaataagcatggg	11	6	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:94757311G>C	uc001kig.2	+	19	2100	c.2034G>C	c.(2032-2034)GAG>GAC	p.E678D	EXOC6_uc010qnr.1_Missense_Mutation_p.E694D|EXOC6_uc001kie.2_Missense_Mutation_p.E673D|EXOC6_uc009xub.2_Missense_Mutation_p.E677D|EXOC6_uc009xuc.2_Missense_Mutation_p.E575D|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Missense_Mutation_p.E252D	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	678					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				TGGACAGTGAGTTAAAACAAA	0.368													0	0	0	0.006214	0	10	81										C	94757311	G	C	94757311	3	2	40	1	0	0	0	0	1	0	0	0	5308	1020	36	4	2198	4	EXOC6	10	94757311	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	489953	94757311	40777436	410	10083										
ALDH18A1	5832	broad.mit.edu	37	chr10	97376261	97376261	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acggcctccttgactccatgGattgagagagcctcctgggt	12	12	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:97376261G>A	uc001kkz.2	-	13	1820	c.1578C>T	c.(1576-1578)ATC>ATT	p.I526I	ALDH18A1_uc001kky.2_Silent_p.I524I|ALDH18A1_uc010qog.1_Silent_p.I415I|ALDH18A1_uc010qoh.1_Silent_p.I314I	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	526	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	TGACTCCATGGATTGAGAGAG	0.547													0	0	0	0.009096	0	4	3										A	97376261	G	A	97376261	2	1	40	1	0	0	0	0	0	0	0	1	489	1164	41	1		1	ALDH18A1	10	97376261	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2618950	97376261	38158486	411	10084										
DNTT	1791	broad.mit.edu	37	chr10	98078150	98078150	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcagagaacaactcgggttCggatgttctggagtggcttc	14	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:98078150C>T	uc001kmf.2	+	2	415	c.245C>T	c.(244-246)TCG>TTG	p.S82L	DNTT_uc001kmg.2_Missense_Mutation_p.S82L	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	82	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AACTCGGGTTCGGATGTTCTG	0.473													0	0	0	0.010771	0	42	251										T	98078150	C	T	98078150	3	4	40	1	0	0	0	0	1	0	0	0	4680	893	31	1	251	1	DNTT	10	98078150	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	701889	98078150	37456597	412	10085										
ARHGAP19	84986	broad.mit.edu	37	chr10	99023225	99023225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttatgtgtcagcagaggctCcggcaactctcctagaaaca	9	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:99023225C>T	uc001knb.2	-	4	594	c.565G>A	c.(565-567)GAG>AAG	p.E189K	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.E180K|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.E189K|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	189	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		AGCAGAGGCTCCGGCAACTCT	0.403													0	0	0	0.01441	0	58	169										T	99023225	C	T	99023225	3	4	40	1	0	0	0	0	1	0	0	0	869	864	30	1	955	1	ARHGAP19	10	99023225	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	945075	99023225	36511522	413	10086										
ENTPD7	57089	broad.mit.edu	37	chr10	101445633	101445633	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcacagtctcaagcagaagtGatctctgggaagcaggaagg	13	8	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:101445633G>A	uc001kqa.3	+	6	811	c.633G>A	c.(631-633)GTG>GTA	p.V211V	ENTPD7_uc009xwl.2_Silent_p.V213V	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	211	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		AAGCAGAAGTGATCTCTGGGA	0.468													0	0	0	0.00623	0	39	57										A	101445633	G	A	101445633	2	1	40	1	0	0	0	0	0	0	0	1	5144	1277	45	1		1	ENTPD7	10	101445633	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2422408	101445633	34089114	414	10087										
PDZD7	79955	broad.mit.edu	37	chr10	102777862	102777862	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcccactacttacctttctCtatgtccaggcgagggtaag	9	12	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:102777862C>T	uc001kso.1	-	9	1731	c.1516G>A	c.(1516-1518)GAG>AAG	p.E506K	PDZD7_uc001ksn.2_Missense_Mutation_p.E506K	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	506						cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		TTACCTTTCTCTATGTCCAGG	0.418													0	0	0	0.010729	0	9	88										T	102777862	C	T	102777862	3	4	40	1	0	0	0	0	1	0	0	0	11704	922	32	1	45	1	PDZD7	10	102777862	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1332229	102777862	32756885	415	10088										
FGF8	2253	broad.mit.edu	37	chr10	103531247	103531247	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcagcttccccttcttgttCatgcagatgtagaggcccgt	9	12	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103531247C>T	uc001ktp.1	-	5	554	c.384G>A	c.(382-384)ATG>ATA	p.M128I	FGF8_uc001ktq.1_Missense_Mutation_p.M139I|FGF8_uc001ktr.1_Missense_Mutation_p.M110I|FGF8_uc001kts.1_Missense_Mutation_p.M99I|FGF8_uc009xwr.1_Missense_Mutation_p.M35I	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	128					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		CCTTCTTGTTCATGCAGATGT	0.607													0	0	0	0.00499	0	16	30										T	103531247	C	T	103531247	3	4	40	1	0	0	0	0	1	0	0	0	5858	826	29	1	325	1	FGF8	10	103531247	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	753385	103531247	32003500	416	10089										
PPRC1	23082	broad.mit.edu	37	chr10	103900177	103900177	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgatcaacccagtcctggctGactcagcagcagttgaccct	9	14	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103900177G>A	uc001kum.2	+	5	1951	c.1912G>A	c.(1912-1914)GAC>AAC	p.D638N	PPRC1_uc001kun.2_Missense_Mutation_p.D518N|PPRC1_uc010qqj.1_Missense_Mutation_p.D638N|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTCCTGGCTGACTCAGCAGC	0.562													0	0	0	0.006122	0	18	69										A	103900177	G	A	103900177	3	1	40	1	0	0	0	0	1	0	0	0	12410	1290	45	1	1930	1	PPRC1	10	103900177	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	368930	103900177	31634570	417	10090										
PPRC1	23082	broad.mit.edu	37	chr10	103900464	103900464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaagaggttgtggattctctGaaaattgaaagtggtaccag	12	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103900464G>A	uc001kum.2	+	5	2238	c.2199G>A	c.(2197-2199)CTG>CTA	p.L733L	PPRC1_uc001kun.2_Silent_p.L613L|PPRC1_uc010qqj.1_Silent_p.L733L|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	733					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TGGATTCTCTGAAAATTGAAA	0.547													0	0	0	0.008361	0	28	84										A	103900464	G	A	103900464	2	1	40	1	0	0	0	0	0	0	0	1	12410	1277	45	1		1	PPRC1	10	103900464	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	287	103900464	31634283	418	10091										
PPRC1	23082	broad.mit.edu	37	chr10	103901412	103901412	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctggccatggagctcctcaGacagagcctaccaaggtgga	12	13	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:103901412G>A	uc001kum.2	+	5	3186	c.3147G>A	c.(3145-3147)CAG>CAA	p.Q1049Q	PPRC1_uc001kun.2_Silent_p.Q929Q|PPRC1_uc010qqj.1_Silent_p.Q1049Q|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1049	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GAGCTCCTCAGACAGAGCCTA	0.582													0	0	0	0.009096	0	4	26										A	103901412	G	A	103901412	2	1	40	1	0	0	0	0	0	0	0	1	12410	933	33	1		1	PPRC1	10	103901412	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	948	103901412	31633335	419	10092										
LOC729020	729020	broad.mit.edu	37	chr10	105006301	105006301	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggagtaggttctgacactgTccataagtgtgcagaggcag	14	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:105006301T>C	uc009xxi.2	+	1	658	c.548T>C	c.(547-549)GTC>GCC	p.V183A	uc001kwr.2_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	rcRPE protein	183					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity				0						TCTGACACTGTCCATAAGTGT	0.448													0	0	0	0.010504	0	22	51										C	105006301	T	C	105006301	3	2	40	1	0	0	0	0	1	0	0	0	8888	1667	58	5	550	5	LOC729020	10	105006301	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	1104889	105006301	30528446	420	10093										
C10orf79	80217	broad.mit.edu	37	chr10	105990389	105990389	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaatcctggaaagctgtatAcgtagatgagaggttttagc	11	6	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:105990389A>G	uc001kxw.2	-	2	394	c.278T>C	c.(277-279)GTA>GCA	p.V93A	C10orf79_uc001kxx.3_Missense_Mutation_p.V93A|C10orf79_uc001kxy.1_Missense_Mutation_p.V93A|C10orf79_uc001kxz.2_Missense_Mutation_p.V93A	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	93											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		AAAGCTGTATACGTAGATGAG	0.428													0	0	0	0.01441	0	51	103										G	105990389	A	G	105990389	3	3	40	1	0	0	0	0	1	0	0	0	1618	391	14	5	4867	5	C10orf79	10	105990389	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	984088	105990389	29544358	421	10094										
ADRA2A	150	broad.mit.edu	37	chr10	112839122	112839122	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgcgccttcaagaagatcctCtgtcggggggacaggaagcg	15	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:112839122C>T	uc001kzo.2	+	1	2333	c.1368C>T	c.(1366-1368)CTC>CTT	p.L456L		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	441	Cytoplasmic (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	AGAAGATCCTCTGTCGGGGGG	0.592													0	0	0	0.004007	0	14	77										T	112839122	C	T	112839122	2	4	40	1	0	0	0	0	0	0	0	1	337	900	32	1		1	ADRA2A	10	112839122	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6848733	112839122	22695625	422	10095										
TACC2	10579	broad.mit.edu	37	chr10	123844346	123844346	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agacaggaatttcatgctggGgtgccacatcccccccaggg	12	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:123844346G>A	uc001lfv.2	+	4	2691	c.2331G>A	c.(2329-2331)GGG>GGA	p.G777G	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.G777G|TACC2_uc010qtv.1_Silent_p.G777G	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	777						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTCATGCTGGGGTGCCACATC	0.632													0	0	0	0.009718	0	40	64										A	123844346	G	A	123844346	2	1	40	1	0	0	0	0	0	0	0	1	15499	1219	43	2		2	TACC2	10	123844346	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	11005224	123844346	11690401	423	10096										
DOCK1	1793	broad.mit.edu	37	chr10	129245729	129245729	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctctgcctctcaaaggcagcGtggcagattacgggaatttg	12	10	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:129245729G>A	uc001ljt.2	+	51	5486	c.5422G>A	c.(5422-5424)GTG>ATG	p.V1808M	DOCK1_uc010qun.1_Missense_Mutation_p.V1829M|DOCK1_uc009yaq.2_Missense_Mutation_p.R807H|DOCK1_uc001ljw.1_5'Flank	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1808	Interaction with NCK2 second and third SH3 domain (minor).				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CAAAGGCAGCGTGGCAGATTA	0.572													0	0	0	0.00308	0	7	15										A	129245729	G	A	129245729	3	1	40	1	0	0	0	0	1	0	0	0	4684	1145	40	2	5624	2	DOCK1	10	129245729	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5401383	129245729	6289018	424	10097										
MKI67	4288	broad.mit.edu	37	chr10	129913744	129913744	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gttctggtcaagctcttgttCaggtgaagcaggctctgcca	12	10	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:129913744C>T	uc001lke.2	-	7	1123	c.928G>A	c.(928-930)GAA>AAA	p.E310K	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	310					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AGCTCTTGTTCAGGTGAAGCA	0.572													0	0	0	0.014323	0	22	110										T	129913744	C	T	129913744	3	4	40	1	0	0	0	0	1	0	0	0	9598	835	29	1	8878	1	MKI67	10	129913744	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	668015	129913744	5621003	425	10098										
PWWP2B	170394	broad.mit.edu	37	chr10	134219559	134219559	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtctcggccagaaggaggacGgagagccgtcttggcgagaa	17	9	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:134219559G>A	uc001lll.3	+	2	1584	c.1555G>A	c.(1555-1557)GGA>AGA	p.G519R	PWWP2B_uc009ybe.2_Intron	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	519	PWWP.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GAAGGAGGACGGAGAGCCGTC	0.537													0	0	0	0.004007	0	16	84										A	134219559	G	A	134219559	3	1	40	1	0	0	0	0	1	0	0	0	12846	1117	39	2	1561	2	PWWP2B	10	134219559	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4305815	134219559	1315188	426	10099										
MTG1	92170	broad.mit.edu	37	chr10	135213089	135213089	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacgtgggcaagtcctccctCatcaactccctccggaggca	9	16	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr10:135213089C>T	uc001lnd.2	+	6	581	c.477C>T	c.(475-477)CTC>CTT	p.L159L	MTG1_uc010qve.1_Intron	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	159	G.					mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		AGTCCTCCCTCATCAACTCCC	0.622													0	0	0	0.005443	0	27	55										T	135213089	C	T	135213089	2	4	40	1	0	0	0	0	0	0	0	1	9926	813	29	1		1	MTG1	10	135213089	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	993530	135213089	321658	427	10100										
MUC6	4588	broad.mit.edu	37	chr11	1025893	1025893	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggatcttgaaggtgggctgtGagtcgttgacaccacagacg	15	8	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:1025893G>C	uc001lsw.2	-	22	2762	c.2711C>G	c.(2710-2712)TCA>TGA	p.S904*		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	904	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTGGGCTGTGAGTCGTTGAC	0.652													0	0	0	0.001168	0	6	17										C	1025893	G	C	1025893	4	2	40	1	0	0	0	0	0	1	0	0	9980	1294	45	1	4656	1	MUC6	11	1025893	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		1025893	133980623	428	10101										
OR51A7	119687	broad.mit.edu	37	chr11	4928820	4928821	+	Missense_Mutation	DNP	CC	CC	TT													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtctctgacatgggcctgtCcctctcctcccttcctacca							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:4928820_4928821CC>TT	uc010qyq.1	+	1	221_222	c.221_222CC>TT	c.(220-222)TCC>TTT	p.S74F		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGGCCTGTCCCTCTCCTCCC	0.46													0	0	0	0.004672	0	7	176										TT	4928821	CC	TT	4928820	3	4	40	1	0	0	0	0	1	0	0	0	11088	855	30	1	223	1	OR51A7	11	4928820	Missense_Mutation	DNP	CC	TCGA-DK-A1A3-01A-11D-A13W-08	3902927	4928820	130077696	429	10102										
OR51Q1	390061	broad.mit.edu	37	chr11	5444186	5444186	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacattctagctgtcctggtCctctacattcccatggttgg	8	13	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:5444186C>G	uc010qzd.1	+	1	756	c.756C>G	c.(754-756)GTC>GTG	p.V252V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGTCCTGGTCCTCTACATTC	0.502													0	0	0	0.006122	0	16	110										G	5444186	C	G	5444186	2	3	40	1	0	0	0	0	0	0	0	1	11104	842	30	1		1	OR51Q1	11	5444186	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	515366	5444186	129562330	430	10103										
SMPD1	6609	broad.mit.edu	37	chr11	6412757	6412757	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggagacgctcagtgctgagCccatctgaggcctgtggcct	14	12	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:6412757C>G	uc001mcw.2	+	2	636	c.462C>G	c.(460-462)AGC>AGG	p.S154R	SMPD1_uc001mcv.1_Intron|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.S154R|SMPD1_uc009yew.2_Missense_Mutation_p.S153R	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	152	Saposin B-type.				cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	CAGTGCTGAGCCCATCTGAGG	0.572													0	0	0	0.004007	0	16	23										G	6412757	C	G	6412757	3	3	40	1	0	0	0	0	1	0	0	0	14804	738	26	4	468	4	SMPD1	11	6412757	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	968571	6412757	128593759	431	10104										
APBB1	322	broad.mit.edu	37	chr11	6432430	6432430	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcccccatggcgctgcgcaGgtccttgggtcccacagctg	12	17	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:6432430G>C	uc001mdb.1	-	2	248	c.148C>G	c.(148-150)CTG>GTG	p.L50V	APBB1_uc001mdc.1_Missense_Mutation_p.L50V|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	50					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GCGCTGCGCAGGTCCTTGGGT	0.697													0	0	0	0.006122	0	18	114										C	6432430	G	C	6432430	3	2	40	1	0	0	0	0	1	0	0	0	759	991	35	4	2036	4	APBB1	11	6432430	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	19673	6432430	128574086	432	10105										
OR10A2	341276	broad.mit.edu	37	chr11	6891489	6891489	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaccacttcttctgtgacagCccacctgtgctgaggctggt	10	13	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:6891489C>A	uc001meu.1	+	1	504	c.504C>A	c.(502-504)AGC>AGA	p.S168R		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCTGTGACAGCCCACCTGTGC	0.532													1	0	1.10923e-09	0.00278	1.14699e-09	19	185										A	6891489	C	A	6891489	3	1	40	1	0	0	0	0	1	0	0	0	10890	738	26	4	506	4	OR10A2	11	6891489	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	459059	6891489	128115027	433	10106										
SBF2	81846	broad.mit.edu	37	chr11	9806738	9806738	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcttcgctccactccattgGatggggagatgctggaattc	11	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:9806738G>A	uc001mib.2	-	37	5303	c.5165C>T	c.(5164-5166)TCC>TTC	p.S1722F	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.S366F|SBF2_uc001mic.2_Missense_Mutation_p.S12F|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1722					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CACTCCATTGGATGGGGAGAT	0.507													0	0	0	0.013537	0	13	66										A	9806738	G	A	9806738	3	1	40	1	0	0	0	0	1	0	0	0	13859	1174	41	1	400	1	SBF2	11	9806738	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2915249	9806738	125199778	434	10107										
MICAL2	9645	broad.mit.edu	37	chr11	12278388	12278388	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcagcgacacgtgttacttCtgtaagaaacgtgtgtacgt	12	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:12278388C>G	uc001mjz.2	+	24	3300	c.3012C>G	c.(3010-3012)TTC>TTG	p.F1004L	MICAL2_uc010rch.1_Missense_Mutation_p.F814L|MICAL2_uc001mka.2_Missense_Mutation_p.F1004L|MICAL2_uc010rci.1_Missense_Mutation_p.F983L|MICAL2_uc001mkb.2_Missense_Mutation_p.F778L|MICAL2_uc001mkc.2_Missense_Mutation_p.F757L|MICAL2_uc001mkd.2_Missense_Mutation_p.F586L|MICAL2_uc010rcj.1_Missense_Mutation_p.F216L|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	1004	LIM zinc-binding.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CGTGTTACTTCTGTAAGAAAC	0.557													0	0	0	0.006214	0	10	49										G	12278388	C	G	12278388	3	3	40	1	0	0	0	0	1	0	0	0	9570	912	32	1	3098	1	MICAL2	11	12278388	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2471650	12278388	122728128	435	10108										
PRRG4	79056	broad.mit.edu	37	chr11	32858272	32858272	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtataatagatttgatctgGagctcttcactcccggcaac	8	10	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:32858272G>C	uc001mtx.2	+	3	425	c.172G>C	c.(172-174)GAG>CAG	p.E58Q		NM_024081	NP_076986	Q9BZD6	TMG4_HUMAN	proline rich Gla (G-carboxyglutamic acid) 4	58	Extracellular (Potential).|Gla.					extracellular region|Golgi apparatus|integral to membrane	calcium ion binding				0	Breast(20;0.206)					ATTTGATCTGGAGCTCTTCAC	0.348													0	0	0	0.00245	0	15	67										C	32858272	G	C	32858272	3	2	40	1	0	0	0	0	1	0	0	0	12608	1175	41	1	178	1	PRRG4	11	32858272	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	20579884	32858272	102148244	436	10109										
TRIM44	54765	broad.mit.edu	37	chr11	35684687	35684687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctggagtgggcgcggccttcGaggaactgcctcacgacggc	16	13	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:35684687G>A	uc001mwi.2	+	1	335	c.28G>A	c.(28-30)GAG>AAG	p.E10K		NM_017583	NP_060053	Q96DX7	TRI44_HUMAN	DIPB protein	10						intracellular	protein binding|zinc ion binding			skin(1)	1	all_lung(20;0.0317)|Lung NSC(22;0.0661)|all_epithelial(35;0.115)	all_hematologic(20;0.107)				CGCGGCCTTCGAGGAACTGCC	0.716													0	0	0	0.00308	0	6	19										A	35684687	G	A	35684687	3	1	40	1	0	0	0	0	1	0	0	0	16516	1059	37	1	30	1	TRIM44	11	35684687	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2826415	35684687	99321829	437	10110										
LRRC4C	57689	broad.mit.edu	37	chr11	40137629	40137629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtgttggtggagatgccatCcggaacctcacgcaggtttt	13	9	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:40137629C>T	uc001mxa.1	-	2	2178	c.214G>A	c.(214-216)GAT>AAT	p.D72N	LRRC4C_uc001mxc.1_Missense_Mutation_p.D68N|LRRC4C_uc001mxd.1_Missense_Mutation_p.D68N|LRRC4C_uc001mxb.1_Missense_Mutation_p.D68N	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	72	LRRNT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GAGATGCCATCCGGAACCTCA	0.527													0	0	0	0.003954	0	24	46										T	40137629	C	T	40137629	3	4	40	1	0	0	0	0	1	0	0	0	9008	855	30	1	1712	1	LRRC4C	11	40137629	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4452942	40137629	94868887	438	10111										
OR4A47	403253	broad.mit.edu	37	chr11	48510885	48510885	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attttttctgtgacatgtatCccttattgaaactggtctgc	7	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:48510885C>G	uc010rhx.1	+	1	541	c.541C>G	c.(541-543)CCC>GCC	p.P181A		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P181L(1)		ovary(1)|skin(1)	2						TGACATGTATCCCTTATTGAA	0.443													0	0	0	0.00245	0	15	280										G	48510885	C	G	48510885	3	3	40	1	0	0	0	0	1	0	0	0	11042	855	30	1	543	1	OR4A47	11	48510885	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	8373256	48510885	86495631	439	10112										
TMX2	51075	broad.mit.edu	37	chr11	57506699	57506699	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggcggccacagattgacaaGaaaggacgggctgtctcatg	14	10	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:57506699G>C	uc001nlc.1	+	7	760	c.711G>C	c.(709-711)AAG>AAC	p.K237N	CTNND1_uc001nlf.1_Intron|TMX2_uc001nld.1_Missense_Mutation_p.K143N|TMX2_uc001nle.1_Missense_Mutation_p.K199N|C11orf31_uc010rjx.1_5'Flank	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	237	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis	integral to membrane					0						AGATTGACAAGAAAGGACGGG	0.453													0	0	0	0.00499	0	16	110										C	57506699	G	C	57506699	3	2	40	1	0	0	0	0	1	0	0	0	16264	933	33	1	737	1	TMX2	11	57506699	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	8995814	57506699	77499817	440	10113										
OR6Q1	219952	broad.mit.edu	37	chr11	57798494	57798494	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgggctttgctggcatccatGaagcacacctcctcttcttc	8	14	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:57798494G>A	uc010rjz.1	+	1	70	c.70G>A	c.(70-72)GAA>AAA	p.E24K	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TGGCATCCATGAAGCACACCT	0.468													0	0	0	0.01441	0	111	305										A	57798494	G	A	57798494	3	1	40	1	0	0	0	0	1	0	0	0	11208	1291	45	1	72	1	OR6Q1	11	57798494	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	291795	57798494	77208022	441	10114										
LPXN	9404	broad.mit.edu	37	chr11	58322349	58322349	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agtcaggtgagccatgagctCatccaactgagcagctgctg	12	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:58322349C>T	uc001nmw.2	-	4	428	c.283G>A	c.(283-285)GAG>AAG	p.E95K	LPXN_uc009ymp.2_5'UTR|LPXN_uc010rkj.1_Missense_Mutation_p.E100K|LPXN_uc010rkk.1_Missense_Mutation_p.E75K	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	95	LD motif 3.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCCATGAGCTCATCCAACTGA	0.498													0	0	0	0.000602	0	4	61										T	58322349	C	T	58322349	3	4	40	1	0	0	0	0	1	0	0	0	8929	835	29	1	901	1	LPXN	11	58322349	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	523855	58322349	76684167	442	10115										
GLYAT	10249	broad.mit.edu	37	chr11	58478139	58478139	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agtcagttccttggctgtttCagctgccatatagagaatgc	10	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:58478139C>T	uc001nnb.2	-	5	567	c.412G>A	c.(412-414)GAA>AAA	p.E138K	GLYAT_uc001nnc.2_Missense_Mutation_p.E138K	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	138					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TTGGCTGTTTCAGCTGCCATA	0.423													0	0	0	0.013114	0	39	199										T	58478139	C	T	58478139	3	4	40	1	0	0	0	0	1	0	0	0	6479	835	29	1	490	1	GLYAT	11	58478139	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	155790	58478139	76528377	443	10116										
MPEG1	219972	broad.mit.edu	37	chr11	58978821	58978821	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cataccttgaggttttcaaaGagtctcagtggaaagtagcc	10	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:58978821G>C	uc001nnu.3	-	1	1674	c.1518C>G	c.(1516-1518)CTC>CTG	p.L506L		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	506	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				GGTTTTCAAAGAGTCTCAGTG	0.512													0	0	0	0.008871	0	19	97										C	58978821	G	C	58978821	2	2	40	1	0	0	0	0	0	0	0	1	9723	929	33	1		1	MPEG1	11	58978821	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	500682	58978821	76027695	444	10117										
OSBP	5007	broad.mit.edu	37	chr11	59349008	59349008	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tagtggtgcccagttgcatgGaaaatacaatgaatggtacc	11	7	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:59349008G>A	uc001noc.1	-	10	2178	c.1698C>T	c.(1696-1698)TTC>TTT	p.F566F	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	566					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CAGTTGCATGGAAAATACAAT	0.413													0	0	0	0.008871	0	21	149										A	59349008	G	A	59349008	2	1	40	1	0	0	0	0	0	0	0	1	11273	1165	41	1		1	OSBP	11	59349008	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	370187	59349008	75657508	445	10118										
MS4A1	931	broad.mit.edu	37	chr11	60229875	60229875	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacccagaaattcagtaaatGggactttcccggcagagcca	9	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:60229875G>A	uc001npp.2	+	3	444	c.28G>A	c.(28-30)GGG>AGG	p.G10R	MS4A1_uc009ymy.1_Missense_Mutation_p.G10R|MS4A1_uc001npq.2_Missense_Mutation_p.G10R|MS4A1_uc009yna.2_Missense_Mutation_p.G10R|MS4A1_uc009ymz.2_Missense_Mutation_p.G10R|MS4A1_uc010rlc.1_Missense_Mutation_p.G10R	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	10	Cytoplasmic (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	TTCAGTAAATGGGACTTTCCC	0.433													0	0	0	0.00623	0	36	85										A	60229875	G	A	60229875	3	1	40	1	0	0	0	0	1	0	0	0	9854	1348	47	2	30	2	MS4A1	11	60229875	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	880867	60229875	74776641	446	10119										
EEF1G	1937	broad.mit.edu	37	chr11	62334336	62334336	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcagcagccagcgcctgctCacattcatccatctcctcct	5	19	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:62334336C>T	uc001ntm.1	-	7	945	c.799G>A	c.(799-801)GAG>AAG	p.E267K	EEF1G_uc010rlw.1_Missense_Mutation_p.E317K|EEF1G_uc001ntn.1_Missense_Mutation_p.E147K	NM_001404	NP_001395	P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1	267					response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						AGCGCCTGCTCACATTCATCC	0.602													0	0	0	0.010818	0	31	53										T	62334336	C	T	62334336	3	4	40	1	0	0	0	0	1	0	0	0	4928	835	29	1	530	1	EEF1G	11	62334336	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2104461	62334336	72672180	447	10120										
HRASLS5	117245	broad.mit.edu	37	chr11	63235859	63235859	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagatggaccacgcaatcatCttctacatagatggcccagt	8	12	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:63235859C>A	uc001nwy.2	-	4	628	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	HRASLS5_uc001nwz.2_Missense_Mutation_p.D142Y|HRASLS5_uc010rmq.1_Missense_Mutation_p.D152Y|HRASLS5_uc009yos.2_Intron	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	152										ovary(1)	1						ACGCAATCATCTTCTACATAG	0.388													1	0	1.13719e-10	0.008361	1.18005e-10	29	192										A	63235859	C	A	63235859	3	1	40	1	0	0	0	0	1	0	0	0	7351	913	32	3	397	3	HRASLS5	11	63235859	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	901523	63235859	71770657	448	10121										
ATG2A	23130	broad.mit.edu	37	chr11	64668054	64668054	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctggggccggttggggccaGagcagcgggaaggggagctc	21	9	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:64668054G>C	uc001obx.2	-	31	4491	c.4376C>G	c.(4375-4377)TCT>TGT	p.S1459C	ATG2A_uc001obw.2_Missense_Mutation_p.S224C	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1459							protein binding			ovary(1)|central_nervous_system(1)	2						GTTGGGGCCAGAGCAGCGGGA	0.667													0	0	0	0.008291	0	10	45										C	64668054	G	C	64668054	3	2	40	1	0	0	0	0	1	0	0	0	1093	942	33	1	1484	1	ATG2A	11	64668054	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1432195	64668054	70338462	449	10122										
RELA	5970	broad.mit.edu	37	chr11	65421919	65421919	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggagaagtcttcatctcctGaaaggaggccattggggagc	14	8	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:65421919G>A	uc001ofg.2	-	11	1726	c.1586C>T	c.(1585-1587)TCA>TTA	p.S529L	RELA_uc001ofh.2_Missense_Mutation_p.S526L|RELA_uc010ron.1_Missense_Mutation_p.S540L|RELA_uc009yqr.2_Missense_Mutation_p.S476L|RELA_uc001ofe.2_3'UTR|RELA_uc001off.2_Missense_Mutation_p.S426L	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	529					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						TTCATCTCCTGAAAGGAGGCC	0.632													0	0	0	0.014323	0	23	56										A	65421919	G	A	65421919	3	1	40	1	0	0	0	0	1	0	0	0	13216	1294	45	1	73	1	RELA	11	65421919	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	753865	65421919	69584597	450	10123										
SF3B2	10992	broad.mit.edu	37	chr11	65824745	65824745	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccgtctcttagtagctgctCcagtgggcccagtgggcccc	12	16	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:65824745C>G	uc001ogy.1	+	7	716	c.676C>G	c.(676-678)CCA>GCA	p.P226A		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	226					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						AGTAGCTGCTCCAGTGGGCCC	0.542													0	0	0	0.011902	0	37	214										G	65824745	C	G	65824745	3	3	40	1	0	0	0	0	1	0	0	0	14151	855	30	1	702	1	SF3B2	11	65824745	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	402826	65824745	69181771	451	10124										
RBM4	5936	broad.mit.edu	37	chr11	66410998	66410998	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagaccagagcggctgctatCggtgcgggaaagaggggcac	18	9	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:66410998C>A	uc009yrj.2	+	3	978	c.490C>A	c.(490-492)CGG>AGG	p.R164R	RBM4_uc009yrk.2_Silent_p.R139R|RBM4_uc001oiw.1_Silent_p.R164R|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Silent_p.R164R|RBM4_uc001oiz.1_Silent_p.R164R	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	164	CCHC-type.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CGGCTGCTATCGGTGCGGGAA	0.567													1	0	0.000274275	0.004482	0.000279026	7	53										A	66410998	C	A	66410998	2	1	40	1	0	0	0	0	0	0	0	1	13134	875	31	3		3	RBM4	11	66410998	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	586253	66410998	68595518	452	10125										
RBM4B	83759	broad.mit.edu	37	chr11	66444285	66444285	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcgaagctcttggttggtaCaagtggggctgatgttaccc	13	9	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:66444285C>T	uc001oja.2	-	1	935	c.266G>A	c.(265-267)TGT>TAT	p.C89Y	RBM4B_uc001ojb.2_Missense_Mutation_p.C89Y	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	89	RRM 2.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						TTGGTTGGTACAAGTGGGGCT	0.488													0	0	0	0.01441	0	124	295										T	66444285	C	T	66444285	3	4	40	1	0	0	0	0	1	0	0	0	13142	478	17	2	821	2	RBM4B	11	66444285	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	33287	66444285	68562231	453	10126										
TPCN2	219931	broad.mit.edu	37	chr11	68838874	68838874	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccatcatctacagtcagttcCggggctacctgatggtgagc	11	12	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:68838874C>T	uc001oos.2	+	10	1062	c.946C>T	c.(946-948)CGG>TGG	p.R316W	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Missense_Mutation_p.R231W|TPCN2_uc010rqg.1_Missense_Mutation_p.R316W|TPCN2_uc001oot.2_5'Flank	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	316	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAGTCAGTTCCGGGGCTACCT	0.602													0	0	0	0.000602	0	5	12										T	68838874	C	T	68838874	3	4	40	1	0	0	0	0	1	0	0	0	16393	643	23	2	984	2	TPCN2	11	68838874	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2394589	68838874	66167642	454	10127										
TSKU	25987	broad.mit.edu	37	chr11	76507283	76507284	+	Frame_Shift_Ins	INS	-	-	C													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccgagacttgcccctgcgINSctacctgagcctggatggga							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:76507283_76507284insC	uc001oxt.2	+	2	795_796	c.623_624insC	c.(622-624)CGCfs	p.R208fs		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	208	LRR 7.					extracellular region					0	Ovarian(111;0.112)					TTGCCCCTGCGCTACCTGAGCC	0.673																		43	127	---	---								C	76507284	-	C	76507283	7	5	40	1	0	1	1	0	0	0	0	0	16624	1087	38	0	625	0	TSKU	11	76507283	Frame_Shift_Ins	INS	-	TCGA-DK-A1A3-01A-11D-A13W-08	7668409	76507283	58499233	455	10128										
PIWIL4	143689	broad.mit.edu	37	chr11	94340677	94340677	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatatttgagctcagactgcCcagtcccaagccaatgtgtg	9	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:94340677C>T	uc001pfa.2	+	14	1922	c.1711C>T	c.(1711-1713)CCA>TCA	p.P571S	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	571	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTCAGACTGCCCAGTCCCAAG	0.423													0	0	0	0.005443	0	26	48										T	94340677	C	T	94340677	3	4	40	1	0	0	0	0	1	0	0	0	11960	623	22	2	1765	2	PIWIL4	11	94340677	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	17833394	94340677	40665839	456	10129										
RDX	5962	broad.mit.edu	37	chr11	110124732	110124732	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttcatctgttgtacttcaaTagtatcaggcttccttcttc	5	11	5	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:110124732T>C	uc001pku.2	-	9	1208	c.898A>G	c.(898-900)ATT>GTT	p.I300V	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Missense_Mutation_p.I300V|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Intron|RDX_uc010rwe.1_Missense_Mutation_p.I164V	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	300					actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TGTACTTCAATAGTATCAGGC	0.408													0	0	0	0.008361	0	32	95										C	110124732	T	C	110124732	3	2	40	1	0	0	0	0	1	0	0	0	13198	1406	49	5	877	5	RDX	11	110124732	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	15784055	110124732	24881784	457	10130										
BUD13	84811	broad.mit.edu	37	chr11	116640940	116640940	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcatccacaatccgcattcTaaatgagaataagaagatca	5	9	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:116640940T>C	uc001ppn.2	-	2	178	c.144_splice	c.e2-1	p.G48_splice	BUD13_uc001ppo.2_Splice_Site_p.G48_splice|BUD13_uc009yzc.2_Splice_Site_p.G48_splice	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1											large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ATCCGCATTCTAAATGAGAAT	0.368													0	0	0	0.00245	0	13	57										C	116640940	T	C	116640940	5	2	40	1	0	0	0	0	0	0	1	0	1573	1536	53	5	1753	5	BUD13	11	116640940	Splice_Site	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	6516208	116640940	18365576	458	10131										
MLL	4297	broad.mit.edu	37	chr11	118344511	118344511	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agtagagagagagaccgggaGagagaaaaggagaataagcg	17	3	0	6			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:118344511G>A	uc001pta.2	+	3	2660	c.2637G>A	c.(2635-2637)GAG>GAA	p.E879E	MLL_uc001ptb.2_Silent_p.E879E|MLL_uc001psz.1_Silent_p.E912E|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	879					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		gagaccgggagagagaaaagg	0.274			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.00278	0	23	54										A	118344511	G	A	118344511	2	1	40	1	0	0	0	0	0	0	0	1	9620	933	33	1		1	MLL	11	118344511	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1703571	118344511	16662005	459	10132										
TRIM29	23650	broad.mit.edu	37	chr11	120008356	120008356	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gactccgagaaaatggacttGcgcagctcgcccttttcggc	11	13	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:120008356G>C	uc001pwz.2	-	1	508	c.384C>G	c.(382-384)CGC>CGG	p.R128R	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	128					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		AAATGGACTTGCGCAGCTCGC	0.637													0	0	0	0.00874	0	40	215										C	120008356	G	C	120008356	2	2	40	1	0	0	0	0	0	0	0	1	16500	1306	46	4		4	TRIM29	11	120008356	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1663845	120008356	14998160	460	10133										
GRIK4	2900	broad.mit.edu	37	chr11	120673512	120673512	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggctgggcaaggccaaggtcGaagtggacatctttgagctt	15	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:120673512G>C	uc001pxn.2	+	4	480	c.193G>C	c.(193-195)GAA>CAA	p.E65Q	GRIK4_uc009zav.1_Missense_Mutation_p.E65Q|GRIK4_uc009zaw.1_Missense_Mutation_p.E65Q|GRIK4_uc009zax.1_Missense_Mutation_p.E65Q	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	65	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GGCCAAGGTCGAAGTGGACAT	0.602											OREG0021427	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	12	67										C	120673512	G	C	120673512	3	2	40	1	0	0	0	0	1	0	0	0	6776	1059	37	1	199	1	GRIK4	11	120673512	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	665156	120673512	14333004	461	10134										
ROBO4	54538	broad.mit.edu	37	chr11	124757737	124757737	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	actgttggcatgctgcagctCtgcaaagaaagggttggtgg	15	7	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:124757737C>T	uc001qbg.2	-	13	2089	c.1949_splice	c.e13-1	p.E650_splice	ROBO4_uc010sas.1_Splice_Site_p.E505_splice|ROBO4_uc001qbh.2_Splice_Site_p.E540_splice|ROBO4_uc001qbi.2_Splice_Site_p.E208_splice|ROBO4_uc010sat.1_Intron	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout						angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGCTGCAGCTCTGCAAAGAAA	0.562													0	0	0	0.001855	0	14	45										T	124757737	C	T	124757737	5	4	40	1	0	0	0	0	0	0	1	0	13516	927	32	1	1099	1	ROBO4	11	124757737	Splice_Site	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4084225	124757737	10248779	462	10135										
SLC37A2	219855	broad.mit.edu	37	chr11	124949113	124949113	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgggatatttctggaacatCcacgagctctggtactttgt	10	9	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:124949113C>T	uc001qbn.2	+	5	671	c.420C>T	c.(418-420)ATC>ATT	p.I140I	SLC37A2_uc010sau.1_Silent_p.I140I	NM_001145290	NP_001138762	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glycerol-3-phosphate	140					carbohydrate transport|transmembrane transport	integral to membrane				ovary(2)	2	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TCTGGAACATCCACGAGCTCT	0.557													0	0	0	0.007291	0	29	133										T	124949113	C	T	124949113	2	4	40	1	0	0	0	0	0	0	0	1	14598	845	30	1		1	SLC37A2	11	124949113	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	191376	124949113	10057403	463	10136										
ARHGAP32	9743	broad.mit.edu	37	chr11	128910840	128910840	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacctggttttggcactgagTtggtcactgactggggaact	13	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:128910840T>C	uc009zcp.2	-	10	986	c.986A>G	c.(985-987)AAC>AGC	p.N329S	ARHGAP32_uc009zcq.1_Missense_Mutation_p.N289S|ARHGAP32_uc001qfb.2_Missense_Mutation_p.N114S	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	329					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TGGCACTGAGTTGGTCACTGA	0.398													0	0	0	0.000602	0	5	17										C	128910840	T	C	128910840	3	2	40	1	0	0	0	0	1	0	0	0	881	1725	60	5	5329	5	ARHGAP32	11	128910840	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	3961727	128910840	6095676	464	10137										
BARX2	8538	broad.mit.edu	37	chr11	129246012	129246012	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctacaagactttcatgatcGacgagatcctctccaaggag	9	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:129246012G>A	uc001qfc.3	+	1	132	c.82G>A	c.(82-84)GAC>AAC	p.D28N		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	28											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		TTTCATGATCGACGAGATCCT	0.617											OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	62	131										A	129246012	G	A	129246012	3	1	40	1	0	0	0	0	1	0	0	0	1316	1058	37	1	84	1	BARX2	11	129246012	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	335172	129246012	5760504	465	10138										
BARX2	8538	broad.mit.edu	37	chr11	129246023	129246023	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcatgatcgacgagatcctCtccaaggagacctgcgatta	9	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:129246023C>G	uc001qfc.3	+	1	143	c.93C>G	c.(91-93)CTC>CTG	p.L31L		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	31											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		ACGAGATCCTCTCCAAGGAGA	0.597											OREG0021508	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	33	178										G	129246023	C	G	129246023	2	3	40	1	0	0	0	0	0	0	0	1	1316	900	32	1		1	BARX2	11	129246023	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	11	129246023	5760493	466	10139										
SNX19	399979	broad.mit.edu	37	chr11	130785628	130785628	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgacctgaagccactccagcGaggctggagcccagccatcc	11	17	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr11:130785628G>A	uc001qgk.3	-	1	755	c.207C>T	c.(205-207)CTC>CTT	p.L69L	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.L69L|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	69					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCACTCCAGCGAGGCTGGAGC	0.602													0	0	0	0.013537	0	8	37										A	130785628	G	A	130785628	2	1	40	1	0	0	0	0	0	0	0	1	14890	1045	37	1		1	SNX19	11	130785628	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1539605	130785628	4220888	467	10140										
CCDC77	84318	broad.mit.edu	37	chr12	538021	538021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacctatttttgtaaggagcCtcctcacaaagtaagtaatc	7	9	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:538021C>T	uc001qig.2	+	6	680	c.500C>T	c.(499-501)CCT>CTT	p.P167L	CCDC77_uc009zdk.2_Missense_Mutation_p.P135L|CCDC77_uc010sdp.1_Missense_Mutation_p.P135L|CCDC77_uc010sdq.1_Missense_Mutation_p.P135L	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	167						centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			TGTAAGGAGCCTCCTCACAAA	0.443													0	0	0	0.01441	0	70	167										T	538021	C	T	538021	3	4	40	1	0	0	0	0	1	0	0	0	2851	681	24	2	514	2	CCDC77	12	538021	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		538021	133313874	468	10141										
NCAPD2	9918	broad.mit.edu	37	chr12	6626188	6626188	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcacccgaattgtccagcaGaaggtaaccaacttctatgt	7	11	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:6626188G>C	uc001qoo.2	+	10	1228	c.1182G>C	c.(1180-1182)CAG>CAC	p.Q394H	NCAPD2_uc009zen.1_Missense_Mutation_p.Q266H|NCAPD2_uc010sfd.1_Missense_Mutation_p.Q349H	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	394	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TTGTCCAGCAGAAGGTAACCA	0.458													0	0	0	0.009535	0	31	154										C	6626188	G	C	6626188	3	2	40	1	0	0	0	0	1	0	0	0	10205	933	33	1	1216	1	NCAPD2	12	6626188	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6088167	6626188	127225707	469	10142										
NCAPD2	9918	broad.mit.edu	37	chr12	6626830	6626830	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttacaagagatgagggcccaGaggcgaactgcagcagcttg	14	9	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:6626830G>C	uc001qoo.2	+	12	1435	c.1389G>C	c.(1387-1389)CAG>CAC	p.Q463H	NCAPD2_uc009zen.1_Missense_Mutation_p.Q335H|NCAPD2_uc010sfd.1_Missense_Mutation_p.Q418H	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	463	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TGAGGGCCCAGAGGCGAACTG	0.483													0	0	0	0.000602	0	5	51										C	6626830	G	C	6626830	3	2	40	1	0	0	0	0	1	0	0	0	10205	933	33	1	1431	1	NCAPD2	12	6626830	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	642	6626830	127225065	470	10143										
ZNF384	171017	broad.mit.edu	37	chr12	6777233	6777233	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgctgcctgcacctgttgctGaagatcaggcgggttgtgtt	14	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:6777233G>T	uc010sfh.1	-	11	1589	c.1381C>A	c.(1381-1383)CAG>AAG	p.Q461K	ZNF384_uc001qpz.2_Missense_Mutation_p.Q400K|ZNF384_uc001qqa.2_Missense_Mutation_p.Q400K|ZNF384_uc001qqb.2_Missense_Mutation_p.Q384K|ZNF384_uc001qqc.2_Missense_Mutation_p.Q400K|ZNF384_uc001qqd.2_Missense_Mutation_p.Q345K|ZNF384_uc001qqe.2_Missense_Mutation_p.Q384K	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	461	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8						acctgttgctgAAGATCAGGC	0.204			T	EWSR1|TAF15 	ALL								1	0	9.31168e-06	0.001855	9.5059e-06	10	49										T	6777233	G	T	6777233	3	4	40	1	0	0	0	0	1	0	0	0	17872	1299	45	3	356	3	ZNF384	12	6777233	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	150403	6777233	127074662	471	10144										
CD163L1	283316	broad.mit.edu	37	chr12	7559389	7559389	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccttccttggattttcagctCtactctccccatacagcggt	6	15	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:7559389C>G	uc001qsy.2	-	5	852	c.826G>C	c.(826-828)GAG>CAG	p.E276Q	CD163L1_uc010sge.1_Missense_Mutation_p.E286Q	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	276	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ATTTTCAGCTCTACTCTCCCC	0.473													0	0	0	0.012319	0	19	110										G	7559389	C	G	7559389	3	3	40	1	0	0	0	0	1	0	0	0	2968	922	32	1	3595	1	CD163L1	12	7559389	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	782156	7559389	126292506	472	10145										
CLEC9A	283420	broad.mit.edu	37	chr12	10218209	10218209	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtattttatctgtgagaagtAtgcgttgagatcctctgtct	10	6	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:10218209A>C	uc001qxa.2	+	9	1317	c.704A>C	c.(703-705)TAT>TCT	p.Y235S		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	235	Extracellular (Potential).				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						TGTGAGAAGTATGCGTTGAGA	0.448													0	0	0	0.013726	0	31	145										C	10218209	A	C	10218209	3	2	40	1	0	0	0	0	1	0	0	0	3522	449	16	5	726	5	CLEC9A	12	10218209	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	2658820	10218209	123633686	473	10146										
DUSP16	80824	broad.mit.edu	37	chr12	12630725	12630725	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcctttgtcctgctgcctctGaggtagcagagtcggcacag	13	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:12630725G>A	uc001rao.1	-	7	1672	c.1040C>T	c.(1039-1041)TCA>TTA	p.S347L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.S199L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	347					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		TGCTGCCTCTGAGGTAGCAGA	0.537													0	0	0	0.008361	0	27	46										A	12630725	G	A	12630725	3	1	40	1	0	0	0	0	1	0	0	0	4816	1294	45	1	961	1	DUSP16	12	12630725	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2412516	12630725	121221170	474	10147			3	41		3	3	186	G		9.749587e-06
DUSP16	80824	broad.mit.edu	37	chr12	12630832	12630832	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttctccaggtgcagcagcttGagtttgctctttggccctga	11	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:12630832G>C	uc001rao.1	-	7	1565	c.933C>G	c.(931-933)CTC>CTG	p.L311L	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Silent_p.L163L	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	311					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		GCAGCAGCTTGAGTTTGCTCT	0.517													0	0	0	0.01441	0	49	92										C	12630832	G	C	12630832	2	2	40	1	0	0	0	0	0	0	0	1	4816	1277	45	1		1	DUSP16	12	12630832	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	107	12630832	121221063	475	10148			3	41		3	3	186	G		9.749587e-06
DUSP16	80824	broad.mit.edu	37	chr12	12630910	12630910	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggagttggcccagaaaattGaagtttggagatatagtagg	14	3	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:12630910G>A	uc001rao.1	-	7	1487	c.855C>T	c.(853-855)TTC>TTT	p.F285F	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Silent_p.F137F	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	285	Tyrosine-protein phosphatase.				inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CCAGAAAATTGAAGTTTGGAG	0.398													0	0	0	0.01441	0	60	152										A	12630910	G	A	12630910	2	1	40	1	0	0	0	0	0	0	0	1	4816	1281	45	1		1	DUSP16	12	12630910	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	78	12630910	121220985	476	10149			3	41		3	3	186	G		9.749587e-06
ETNK1	55500	broad.mit.edu	37	chr12	22778128	22778128	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccgcccgcggtccagctccGacaacaggaattttctccga	10	16	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:22778128G>A	uc001rft.2	+	1	53	c.31G>A	c.(31-33)GAC>AAC	p.D11N	ETNK1_uc009ziz.2_Missense_Mutation_p.D11N|ETNK1_uc001rfs.2_Missense_Mutation_p.D11N	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	11					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						GTCCAGCTCCGACAACAGGAA	0.716													0	0	0	0.009096	0	3	5										A	22778128	G	A	22778128	3	1	40	1	0	0	0	0	1	0	0	0	5273	1058	37	1	33	1	ETNK1	12	22778128	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10147218	22778128	111073767	477	10150										
C12orf11	55726	broad.mit.edu	37	chr12	27067466	27067466	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atcgattttatatctggggtCtagaaaaggagttaatctgt	10	4	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:27067466C>G	uc001rhk.3	-	12	1831	c.1294G>C	c.(1294-1296)GAC>CAC	p.D432H	C12orf11_uc001rhj.3_Intron|C12orf11_uc010sjk.1_Missense_Mutation_p.D331H	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	432					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					TATCTGGGGTCTAGAAAAGGA	0.348													0	0	0	0.00499	0	17	63										G	27067466	C	G	27067466	3	3	40	1	0	0	0	0	1	0	0	0	1675	913	32	1	850	1	C12orf11	12	27067466	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4289338	27067466	106784429	478	10151										
KLHDC5	57542	broad.mit.edu	37	chr12	27933977	27933977	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctggccaacaaccttcctccCgacctggtcaatgtcagggg	10	15	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:27933977C>T	uc001rij.2	+	1	791	c.714C>T	c.(712-714)CCC>CCT	p.P238P	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	238	Kelch 2.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					ACCTTCCTCCCGACCTGGTCA	0.622													0	0	0	0.001984	0	7	15										T	27933977	C	T	27933977	2	4	40	1	0	0	0	0	0	0	0	1	8359	639	23	2		2	KLHDC5	12	27933977	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	866511	27933977	105917918	479	10152										
TMTC1	83857	broad.mit.edu	37	chr12	29757224	29757224	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgactaaaacctccttgtgCtccagtctctgaaacacaca	5	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:29757224C>T	uc001rjb.2	-	7	1287	c.813G>A	c.(811-813)GAG>GAA	p.E271E	TMTC1_uc001riz.2_Silent_p.E28E|TMTC1_uc001rja.2_Silent_p.E115E|TMTC1_uc001rjc.1_Silent_p.E333E	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	379						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CCTCCTTGTGCTCCAGTCTCT	0.468													0	0	0	0.004482	0	9	30										T	29757224	C	T	29757224	2	4	40	1	0	0	0	0	0	0	0	1	16257	796	28	2		2	TMTC1	12	29757224	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1823247	29757224	104094671	480	10153										
DENND5B	160518	broad.mit.edu	37	chr12	31613259	31613259	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacataaacatgttgccattGaaatgggaacaaaagtgtgg	10	6	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:31613259G>A	uc001rki.1	-	4	1147	c.961C>T	c.(961-963)CAA>TAA	p.Q321*	DENND5B_uc001rkh.1_Nonsense_Mutation_p.Q356*|DENND5B_uc009zjq.1_Nonsense_Mutation_p.Q240*|DENND5B_uc001rkj.2_Nonsense_Mutation_p.Q343*|DENND5B_uc001rkk.1_Nonsense_Mutation_p.Q243*	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	321	DENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						TGTTGCCATTGAAATGGGAAC	0.438													0	0	0	0.014323	0	23	33										A	31613259	G	A	31613259	4	1	40	1	0	0	0	0	0	1	0	0	4437	1299	45	1	2935	1	DENND5B	12	31613259	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1856035	31613259	102238636	481	10154										
PDZRN4	29951	broad.mit.edu	37	chr12	41967407	41967407	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaaatggggcgctactggagCaaagaggagagaaagcagca	15	6	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:41967407C>T	uc010skn.1	+	10	2297	c.2229C>T	c.(2227-2229)AGC>AGT	p.S743S	PDZRN4_uc001rmq.3_Silent_p.S684S|PDZRN4_uc009zjz.2_Silent_p.S682S|PDZRN4_uc001rmr.2_Silent_p.S569S	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	942							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GCTACTGGAGCAAAGAGGAGA	0.542													0	0	0	0.00499	0	17	41										T	41967407	C	T	41967407	2	4	40	1	0	0	0	0	0	0	0	1	11710	709	25	2		2	PDZRN4	12	41967407	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	10354148	41967407	91884488	482	10155										
PRICKLE1	144165	broad.mit.edu	37	chr12	42854114	42854114	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgagacctggatcccctctCttcaaaattgtagacgcgtc	8	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:42854114C>A	uc010skv.1	-	8	2280	c.1993G>T	c.(1993-1995)GAG>TAG	p.E665*	PRICKLE1_uc001rnl.2_Nonsense_Mutation_p.E665*|PRICKLE1_uc010skw.1_Nonsense_Mutation_p.E665*|PRICKLE1_uc001rnm.2_Nonsense_Mutation_p.E665*|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	665	Arg/His-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GATCCCCTCTCTTCAAAATTG	0.483													1	0	0.000566183	0.00499	0.000575326	17	79										A	42854114	C	A	42854114	4	1	40	1	0	0	0	0	0	1	0	0	12486	922	32	3	506	3	PRICKLE1	12	42854114	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	886707	42854114	90997781	483	10156										
ANO6	196527	broad.mit.edu	37	chr12	45782045	45782045	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacaagcccgaccagaatacGaagcacgatgtactcacgta	8	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:45782045G>A	uc001roo.2	+	11	1602	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K	ANO6_uc010sld.1_Missense_Mutation_p.E423K|ANO6_uc010sle.1_Missense_Mutation_p.E423K|ANO6_uc010slf.1_Missense_Mutation_p.E444K|ANO6_uc010slg.1_Missense_Mutation_p.E405K	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	423	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						ACCAGAATACGAAGCACGATG	0.403													0	0	0	0.01441	0	55	128										A	45782045	G	A	45782045	3	1	40	1	0	0	0	0	1	0	0	0	701	1059	37	1	1329	1	ANO6	12	45782045	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2927931	45782045	88069850	484	10157										
TROAP	10024	broad.mit.edu	37	chr12	49721057	49721057	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgaaggaggtgtggcctctCttggtctggcccagcgagta	15	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:49721057C>G	uc001rtx.3	+	8	1002	c.835C>G	c.(835-837)CTT>GTT	p.L279V	TROAP_uc009zlh.2_Missense_Mutation_p.L279V|TROAP_uc001rty.2_5'UTR	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	279					cell adhesion	cytoplasm				ovary(1)	1						TGTGGCCTCTCTTGGTCTGGC	0.512													0	0	0	0.00278	0	21	146										G	49721057	C	G	49721057	3	3	40	1	0	0	0	0	1	0	0	0	16572	913	32	1	963	1	TROAP	12	49721057	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3939012	49721057	84130838	485	10158										
SPATS2	65244	broad.mit.edu	37	chr12	49890687	49890687	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcactctattcacaattctCaacaacccaggaatgctgcc	5	14	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:49890687C>T	uc001rud.2	+	8	1587	c.598C>T	c.(598-600)CAA>TAA	p.Q200*	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Nonsense_Mutation_p.Q200*|SPATS2_uc001ruf.2_Nonsense_Mutation_p.Q200*|SPATS2_uc001rug.2_Nonsense_Mutation_p.Q200*	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	200						cytoplasm				breast(1)	1						TCACAATTCTCAACAACCCAG	0.433													0	0	0	0.01441	0	62	126										T	49890687	C	T	49890687	4	4	40	1	0	0	0	0	0	1	0	0	15018	827	29	1	620	1	SPATS2	12	49890687	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	169630	49890687	83961208	486	10159										
SPATS2	65244	broad.mit.edu	37	chr12	49918549	49918549	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagtagcccaagtgatgcctCtgctgcttcctcttccacct	8	15	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:49918549C>T	uc001rud.2	+	13	2185	c.1196C>T	c.(1195-1197)TCT>TTT	p.S399F	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.S399F|SPATS2_uc001ruf.2_Missense_Mutation_p.S399F|SPATS2_uc001rug.2_Missense_Mutation_p.S399F	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	399	Ser-rich.					cytoplasm				breast(1)	1						AGTGATGCCTCTGCTGCTTCC	0.493													0	0	0	0.01441	0	63	136										T	49918549	C	T	49918549	3	4	40	1	0	0	0	0	1	0	0	0	15018	913	32	1	1238	1	SPATS2	12	49918549	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	27862	49918549	83933346	487	10160										
TMPRSS12	283471	broad.mit.edu	37	chr12	51279160	51279160	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgatgaagatggagcttttGatacttgcagggtaagacca	13	5	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:51279160G>A	uc001rwx.3	+	4	831	c.784G>A	c.(784-786)GAT>AAT	p.D262N	TMPRSS12_uc001rwy.2_Missense_Mutation_p.D262N	NM_182559	NP_872365	Q86WS5	TMPSC_HUMAN	transmembrane protease, serine 12 precursor	262	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity				0						TGGAGCTTTTGATACTTGCAG	0.378													0	0	0	0.01441	0	92	223										A	51279160	G	A	51279160	3	1	40	1	0	0	0	0	1	0	0	0	16241	1290	45	1	798	1	TMPRSS12	12	51279160	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1360611	51279160	82572735	488	10161										
DAZAP2	9802	broad.mit.edu	37	chr12	51634204	51634204	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcagaccttgcatcttcctCaggctccaccctataccgat	5	17	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:51634204C>G	uc010snd.1	+	2	275	c.91C>G	c.(91-93)CAG>GAG	p.Q31E	DAZAP2_uc001ryb.2_Missense_Mutation_p.Q31E|DAZAP2_uc010snc.1_Missense_Mutation_p.Q31E|DAZAP2_uc010sne.1_Missense_Mutation_p.Q31E|DAZAP2_uc010snf.1_Missense_Mutation_p.Q31E	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	31	Pro-rich.						WW domain binding				0						GCATCTTCCTCAGGCTCCACC	0.488													0	0	0	0.010504	0	21	115										G	51634204	C	G	51634204	3	3	40	1	0	0	0	0	1	0	0	0	4245	827	29	1	97	1	DAZAP2	12	51634204	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	355044	51634204	82217691	489	10162										
MFSD5	84975	broad.mit.edu	37	chr12	53647277	53647277	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggcaggggccttggcccttCgaaactggggggagaactat	16	9	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:53647277C>T	uc001sci.1	+	2	849	c.658C>T	c.(658-660)CGA>TGA	p.R220*	MFSD5_uc001sch.1_Nonsense_Mutation_p.R327*	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	220					transport	integral to membrane				skin(2)|ovary(1)	3						CTTGGCCCTTCGAAACTGGGG	0.662													0	0	0	0.003271	0	32	79										T	53647277	C	T	53647277	4	4	40	1	0	0	0	0	0	1	0	0	9534	876	31	1	985	1	MFSD5	12	53647277	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2013073	53647277	80204618	490	10163										
ESPL1	9700	broad.mit.edu	37	chr12	53677897	53677897	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctggcccgcaatgacattGatctctgtcagtcggacctg	11	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:53677897G>A	uc001sck.2	+	17	3224	c.3133G>A	c.(3133-3135)GAT>AAT	p.D1045N	ESPL1_uc001scj.2_Missense_Mutation_p.D720N|ESPL1_uc010soe.1_Missense_Mutation_p.D256N	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1045					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CAATGACATTGATCTCTGTCA	0.542													0	0	0	0.01441	0	77	222										A	53677897	G	A	53677897	3	1	40	1	0	0	0	0	1	0	0	0	5253	1290	45	1	3195	1	ESPL1	12	53677897	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	30620	53677897	80173998	491	10164										
HOXC6	3223	broad.mit.edu	37	chr12	54423560	54423560	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggcgccggcgcatcgagatCgccaacgcgctttgcctgac	13	16	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:54423560C>T	uc001sev.2	+	2	634	c.522C>T	c.(520-522)ATC>ATT	p.I174I	HOXC6_uc001ses.2_Silent_p.I92I|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	174	Homeobox.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						GCATCGAGATCGCCAACGCGC	0.562													0	0	0	0.00333	0	24	92										T	54423560	C	T	54423560	2	4	40	1	0	0	0	0	0	0	0	1	7315	874	31	1		1	HOXC6	12	54423560	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	745663	54423560	79428335	492	10165										
DGKA	1606	broad.mit.edu	37	chr12	56334172	56334172	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtcagaaaaagatccggatCtaccacagtctgaccgggct	10	11	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:56334172C>T	uc001sij.2	+	11	1137	c.873C>T	c.(871-873)ATC>ATT	p.I291I	DGKA_uc009zoc.1_Silent_p.I291I|DGKA_uc001sih.1_Silent_p.I179I|DGKA_uc001sii.1_Silent_p.I149I|DGKA_uc009zod.1_Silent_p.I210I|DGKA_uc009zoe.1_3'UTR|DGKA_uc001sik.2_Silent_p.I291I|DGKA_uc001sil.2_Silent_p.I291I|DGKA_uc001sim.2_Silent_p.I291I|DGKA_uc001sin.2_Silent_p.I291I|DGKA_uc009zof.2_5'UTR|DGKA_uc001sio.2_Silent_p.I33I	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	291	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	AGATCCGGATCTACCACAGTC	0.582											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	38	84										T	56334172	C	T	56334172	2	4	40	1	0	0	0	0	0	0	0	1	4465	903	32	1		1	DGKA	12	56334172	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1910612	56334172	77517723	493	10166										
ESYT1	23344	broad.mit.edu	37	chr12	56536448	56536448	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgagtgaagaaccagagctCtcggggggaccccctcacat	12	13	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:56536448C>T	uc001sjq.2	+	26	2870	c.2820C>T	c.(2818-2820)CTC>CTT	p.L940L	ESYT1_uc001sjr.2_Silent_p.L950L	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	940						integral to membrane				ovary(4)|skin(1)	5						AACCAGAGCTCTCGGGGGGAC	0.602													0	0	0	0.008291	0	11	60										T	56536448	C	T	56536448	2	4	40	1	0	0	0	0	0	0	0	1	5264	900	32	1		1	ESYT1	12	56536448	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	202276	56536448	77315447	494	10167										
TIMELESS	8914	broad.mit.edu	37	chr12	56816695	56816695	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctgtgttcttccagaacaAcagctccacaaaggcttttt	7	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:56816695A>C	uc001slf.2	-	19	2542	c.2374T>G	c.(2374-2376)TTG>GTG	p.L792V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	792					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TTCCAGAACAACAGCTCCACA	0.502													0	0	0	0.011902	0	47	102										C	56816695	A	C	56816695	3	2	40	1	0	0	0	0	1	0	0	0	15901	40	2	5	1296	5	TIMELESS	12	56816695	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	280247	56816695	77035200	495	10168										
MYO1A	4640	broad.mit.edu	37	chr12	57436895	57436895	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgattcactatccagtcaaaGaggcggctgtagatgttctt	10	9	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:57436895G>C	uc001smw.3	-	12	1302	c.1059C>G	c.(1057-1059)CTC>CTG	p.L353L	MYO1A_uc010sqz.1_Silent_p.L191L|MYO1A_uc009zpd.2_Silent_p.L353L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	353	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TCCAGTCAAAGAGGCGGCTGT	0.547													0	0	0	0.001168	0	6	52										C	57436895	G	C	57436895	2	2	40	1	0	0	0	0	0	0	0	1	10068	929	33	1		1	MYO1A	12	57436895	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	620200	57436895	76415000	496	10169										
MBD6	114785	broad.mit.edu	37	chr12	57920498	57920498	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctttccctttccccagccctGagcagggcctggcactgagt	10	16	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:57920498G>A	uc001soj.1	+	7	1794	c.1570G>A	c.(1570-1572)GAG>AAG	p.E524K	MBD6_uc001sok.1_Missense_Mutation_p.E391K|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	524	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCCCAGCCCTGAGCAGGGCCT	0.652													0	0	0	0.00278	0	24	84										A	57920498	G	A	57920498	3	1	40	1	0	0	0	0	1	0	0	0	9348	1291	45	1	1588	1	MBD6	12	57920498	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	483603	57920498	75931397	497	10170										
OS9	10956	broad.mit.edu	37	chr12	58114292	58114292	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacctcaaggagatcttcttCaatatcttggtaagaggctt	8	8	5	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:58114292C>T	uc001spj.2	+	14	1928	c.1869C>T	c.(1867-1869)TTC>TTT	p.F623F	OS9_uc010srx.1_Silent_p.F362F|OS9_uc001spk.2_Silent_p.F608F|OS9_uc001spl.2_Silent_p.F568F|OS9_uc001spm.2_Silent_p.F553F|OS9_uc001spn.2_Silent_p.F569F|OS9_uc010sry.1_Silent_p.F536F|OS9_uc010srz.1_Silent_p.F494F	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	623					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			AGATCTTCTTCAATATCTTGG	0.299													0	0	0	0.000602	0	5	51										T	58114292	C	T	58114292	2	4	40	1	0	0	0	0	0	0	0	1	11272	825	29	1		1	OS9	12	58114292	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	193794	58114292	75737603	498	10171										
RAP1B	5908	broad.mit.edu	37	chr12	69044231	69044231	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaaaatacgatcctacgataGaagattcttatagaaaggta	7	5	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:69044231G>C	uc001sub.2	+	3	272	c.109G>C	c.(109-111)GAA>CAA	p.E37Q	RAP1B_uc010ste.1_Intron|RAP1B_uc001suc.2_Missense_Mutation_p.E37Q|RAP1B_uc010stf.1_Missense_Mutation_p.E37Q|RAP1B_uc010stg.1_Intron|RAP1B_uc010sth.1_Intron|RAP1B_uc010sti.1_Missense_Mutation_p.E37Q	NM_001089704	NP_001083173	P61224	RAP1B_HUMAN	SubName: Full=Ras-related protein Rap-1A; SubName: Full=cDNA FLJ75985, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA; SubName: Full=RAP1A, member of RAS oncogene family;	37	Effector region (Probable).			E->A: Strong reduction in nucleotide exchange with EPAC2.	blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding				0	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		TCCTACGATAGAAGATTCTTA	0.234													0	0	0	0.00308	0	6	50										C	69044231	G	C	69044231	3	2	40	1	0	0	0	0	1	0	0	0	13036	943	33	1	115	1	RAP1B	12	69044231	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10929939	69044231	64807664	499	10172										
NUP107	57122	broad.mit.edu	37	chr12	69126474	69126474	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tatttgacccagcgcagaggGcagaagcactgaaacaaggc	12	10	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:69126474G>T	uc001suf.2	+	23	2171	c.2056G>T	c.(2056-2058)GCA>TCA	p.A686S	NUP107_uc001sug.2_Missense_Mutation_p.A445S|NUP107_uc010stj.1_Missense_Mutation_p.A657S	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	686					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AGCGCAGAGGGCAGAAGCACT	0.274													1	0	4.26978e-12	0.00333	4.44117e-12	22	43										T	69126474	G	T	69126474	3	4	40	1	0	0	0	0	1	0	0	0	10753	1203	42	4	2146	4	NUP107	12	69126474	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	82243	69126474	64725421	500	10173										
BEST3	144453	broad.mit.edu	37	chr12	70088210	70088210	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acagtaaattgataatttttCaaagtaacgtttttggactc	6	5	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:70088210C>G	uc001svg.2	-	3	414	c.187G>C	c.(187-189)GAA>CAA	p.E63Q	BEST3_uc001svd.1_Missense_Mutation_p.E63Q|BEST3_uc001sve.1_Intron|BEST3_uc010stm.1_Intron|BEST3_uc001svh.2_Intron|BEST3_uc001svi.1_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	63	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GATAATTTTTCAAAGTAACGT	0.378													0	0	0	0.00308	0	8	41										G	70088210	C	G	70088210	3	3	40	1	0	0	0	0	1	0	0	0	1406	835	29	1	1851	1	BEST3	12	70088210	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	961736	70088210	63763685	501	10174										
KCNC2	3747	broad.mit.edu	37	chr12	75437006	75437006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgctatgttgtttaagcttCgggatttttcatatcctttt	7	8	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:75437006C>T	uc001sxg.1	-	5	2340	c.1796G>A	c.(1795-1797)CGA>CAA	p.R599Q	KCNC2_uc009zry.2_Intron|KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Missense_Mutation_p.R544Q	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	599	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GTTTAAGCTTCGGGATTTTTC	0.433													0	0	0	0.001855	0	12	72										T	75437006	C	T	75437006	3	4	40	1	0	0	0	0	1	0	0	0	8015	884	31	1	190	1	KCNC2	12	75437006	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5348796	75437006	58414889	502	10175										
LRRIQ1	84125	broad.mit.edu	37	chr12	85547824	85547824	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttctactgctcagcaaatgTtgaagagggcacagaaaatg	10	7	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:85547824T>C	uc001tac.2	+	23	4783	c.4672T>C	c.(4672-4674)TTG>CTG	p.L1558L		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1558										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TCAGCAAATGTTGAAGAGGGC	0.289													0	0	0	0.008291	0	9	28										C	85547824	T	C	85547824	2	2	40	1	0	0	0	0	0	0	0	1	9029	1722	60	5		5	LRRIQ1	12	85547824	Silent	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	10110818	85547824	48304071	503	10176										
DUSP6	1848	broad.mit.edu	37	chr12	89743278	89743278	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aagccacagtcacagtgactGagcggctaatgccagccaag	11	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:89743278G>A	uc001tay.2	-	3	1379	c.899C>T	c.(898-900)TCA>TTA	p.S300L	DUSP6_uc001taz.2_Missense_Mutation_p.S154L	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	300	Tyrosine-protein phosphatase.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						CACAGTGACTGAGCGGCTAAT	0.458													0	0	0	0.003755	0	35	99										A	89743278	G	A	89743278	3	1	40	1	0	0	0	0	1	0	0	0	4829	1294	45	1	250	1	DUSP6	12	89743278	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4195454	89743278	44108617	504	10177										
ATP2B1	490	broad.mit.edu	37	chr12	90005096	90005096	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtattaatattatcaccagtGaccatccgcacagtaattcc	5	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:90005096G>C	uc001tbh.2	-	12	2302	c.2121C>G	c.(2119-2121)GTC>GTG	p.V707V	ATP2B1_uc001tbg.2_Silent_p.V707V|ATP2B1_uc001tbf.2_Silent_p.V377V	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	707	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TATCACCAGTGACCATCCGCA	0.358													0	0	0	0.01441	0	67	410										C	90005096	G	C	90005096	2	2	40	1	0	0	0	0	0	0	0	1	1139	1277	45	1		1	ATP2B1	12	90005096	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	261818	90005096	43846799	505	10178										
TMCC3	57458	broad.mit.edu	37	chr12	94965382	94965382	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacactaagatgacagtcatGaaggccaggatcacgttgat	10	9	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:94965382G>A	uc001tdj.2	-	4	1381	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	TMCC3_uc001tdi.2_Silent_p.F390F	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	421	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2						TGACAGTCATGAAGGCCAGGA	0.532													0	0	0	0.008361	0	29	75										A	94965382	G	A	94965382	2	1	40	1	0	0	0	0	0	0	0	1	15991	1281	45	1		1	TMCC3	12	94965382	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4960286	94965382	38886513	506	10179										
C12orf48	55010	broad.mit.edu	37	chr12	102559617	102559617	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttgtctaattttattaatttCattgacaaattagatgagat	5	3	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:102559617C>T	uc001tjf.2	+	6	889	c.777C>T	c.(775-777)TTC>TTT	p.F259F	C12orf48_uc001tjg.2_Silent_p.F178F|C12orf48_uc010swa.1_Silent_p.F336F|C12orf48_uc001tjh.2_Silent_p.F178F|C12orf48_uc010swb.1_Silent_p.F145F|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_5'UTR|C12orf48_uc001tjk.2_Silent_p.F259F|C12orf48_uc009zud.2_Silent_p.F259F	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	259					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						TTATTAATTTCATTGACAAAT	0.303													0	0	0	0.012319	0	23	166										T	102559617	C	T	102559617	2	4	40	1	0	0	0	0	0	0	0	1	1692	825	29	1		1	C12orf48	12	102559617	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7594235	102559617	31292278	507	10180										
SLC41A2	84102	broad.mit.edu	37	chr12	105282830	105282830	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccctgcagaagagatgcaatGaaggcagttgccacactgct	11	11	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:105282830G>A	uc001tla.2	-	4	1028	c.861C>T	c.(859-861)TTC>TTT	p.F287F		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	287	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						GAGATGCAATGAAGGCAGTTG	0.353													0	0	0	0.01441	0	59	154										A	105282830	G	A	105282830	2	1	40	1	0	0	0	0	0	0	0	1	14630	1281	45	1		1	SLC41A2	12	105282830	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2723213	105282830	28569065	508	10181										
KIAA1033	23325	broad.mit.edu	37	chr12	105558049	105558049	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaaaactcttacaaaccatGaatctcactcagaagcgact	5	11	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:105558049G>A	uc001tld.2	+	31	3405	c.3318G>A	c.(3316-3318)ATG>ATA	p.M1106I	KIAA1033_uc010swr.1_Missense_Mutation_p.M1107I|KIAA1033_uc010sws.1_Missense_Mutation_p.M918I	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	1106					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TACAAACCATGAATCTCACTC	0.408													0	0	0	0.001855	0	14	52										A	105558049	G	A	105558049	3	1	40	1	0	0	0	0	1	0	0	0	8206	1290	45	1	3440	1	KIAA1033	12	105558049	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	275219	105558049	28293846	509	10182										
NAA25	80018	broad.mit.edu	37	chr12	112477111	112477111	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggtcgtaggacactctcacaGtaactggatacccaaaggat	10	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:112477111G>T	uc001ttm.2	-	22	2591	c.2571C>A	c.(2569-2571)TAC>TAA	p.Y857*	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Nonsense_Mutation_p.Y829*|NAA25_uc009zwa.1_Nonsense_Mutation_p.Y835*	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	857						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						CACTCTCACAGTAACTGGATA	0.328													1	0	1.52319e-26	0.00874	1.61096e-26	40	101										T	112477111	G	T	112477111	4	4	40	1	0	0	0	0	0	1	0	0	10121	1024	36	4	359	4	NAA25	12	112477111	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6919062	112477111	21374784	510	10183										
C12orf51	283450	broad.mit.edu	37	chr12	112608964	112608964	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcgatgctgtgggtatacatGggtgtctggcgcagctccac	15	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:112608964G>A	uc009zwc.2	-	61	10641	c.10623C>T	c.(10621-10623)CCC>CCT	p.P3541P		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GGGTATACATGGGTGTCTGGC	0.632													0	0	0	0.001168	0	5	17										A	112608964	G	A	112608964	2	1	40	1	0	0	0	0	0	0	0	1	1696	1335	47	2		2	C12orf51	12	112608964	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	131853	112608964	21242931	511	10184										
C12orf52	84934	broad.mit.edu	37	chr12	113629482	113629482	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccccccacacaaatgggcctCaggatctcaggccttccacg	8	18	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:113629482C>G	uc001tur.1	+	4	1138	c.670C>G	c.(670-672)CAG>GAG	p.Q224E	C12orf52_uc009zwg.1_Missense_Mutation_p.Q221E|C12orf52_uc001tus.1_Missense_Mutation_p.Q224E|C12orf52_uc001tut.1_Missense_Mutation_p.Q248E	NM_032848	NP_116237	Q96K30	RITA_HUMAN	hypothetical protein LOC84934	224	Interaction with tubulin.				negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|neurogenesis|Notch signaling pathway|nuclear export	centrosome|nucleus	tubulin binding				0						AAATGGGCCTCAGGATCTCAG	0.617													0	0	0	0.008291	0	10	55										G	113629482	C	G	113629482	3	3	40	1	0	0	0	0	1	0	0	0	1697	827	29	1	676	1	C12orf52	12	113629482	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1020518	113629482	20222413	512	10185										
MED13L	23389	broad.mit.edu	37	chr12	116549237	116549237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgttccttctcttacctttCtaacagattgtggatcgctt	6	11	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:116549237C>G	uc001tvw.2	-	3	446	c.391G>C	c.(391-393)GAA>CAA	p.E131Q		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	131					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCTTACCTTTCTAACAGATTG	0.383													0	0	0	0.001855	0	13	114										G	116549237	C	G	116549237	3	3	40	1	0	0	0	0	1	0	0	0	9431	922	32	1	6357	1	MED13L	12	116549237	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2919755	116549237	17302658	513	10186										
CIT	11113	broad.mit.edu	37	chr12	120221778	120221778	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctctgagtctcagaggccttCagctccacctccttctgact	7	16	4	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:120221778C>T	uc001txi.1	-	12	1532	c.1479G>A	c.(1477-1479)CTG>CTA	p.L493L	CIT_uc001txh.1_Silent_p.L27L|CIT_uc001txj.1_Silent_p.L493L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	493	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CAGAGGCCTTCAGCTCCACCT	0.542													0	0	0	0.01441	0	62	273										T	120221778	C	T	120221778	2	4	40	1	0	0	0	0	0	0	0	1	3438	813	29	1		1	CIT	12	120221778	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3672541	120221778	13630117	514	10187										
HIP1R	9026	broad.mit.edu	37	chr12	123342655	123342655	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acccccattgccaggagtctCaggagcaggggctgcggcag	15	13	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:123342655C>G	uc001udj.1	+	19	1881	c.1822C>G	c.(1822-1824)CAG>GAG	p.Q608E	HIP1R_uc001udk.1_5'UTR	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	608					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCAGGAGTCTCAGGAGCAGGG	0.652													0	0	0	0.00499	0	11	91										G	123342655	C	G	123342655	3	3	40	1	0	0	0	0	1	0	0	0	7115	827	29	1	1896	1	HIP1R	12	123342655	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3120877	123342655	10509240	515	10188										
CHFR	55743	broad.mit.edu	37	chr12	133428210	133428210	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcgcgggcactcacactgctGaggggcgacacgcgggtcct	16	14	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr12:133428210G>A	uc001ulf.2	-	12	1606	c.1522C>T	c.(1522-1524)CAG>TAG	p.Q508*	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Nonsense_Mutation_p.Q496*|CHFR_uc010tbs.1_Nonsense_Mutation_p.Q507*|CHFR_uc001uld.2_Nonsense_Mutation_p.Q467*|CHFR_uc010tbt.1_Nonsense_Mutation_p.Q416*	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	508					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCACACTGCTGAGGGGCGACA	0.657													0	0	0	0.01441	0	54	163										A	133428210	G	A	133428210	4	1	40	1	0	0	0	0	0	1	0	0	3337	1299	45	1	500	1	CHFR	12	133428210	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10085555	133428210	423685	516	10189										
PSPC1	55269	broad.mit.edu	37	chr13	20283725	20283725	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggacccatatcacccattctCatttcctgttctctctgtaa	4	14	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:20283725C>T	uc001uml.2	-	7	1359	c.1173G>A	c.(1171-1173)ATG>ATA	p.M391I	PSPC1_uc001umj.1_Intron|PSPC1_uc001umk.1_Intron	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		CACCCATTCTCATTTCCTGTT	0.373													0	0	0	0.01441	0	50	115										T	20283725	C	T	20283725	3	4	40	1	0	0	0	0	1	0	0	0	12716	826	29	1	410	1	PSPC1	13	20283725	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		20283725	94886153	517	10190										
SACS	26278	broad.mit.edu	37	chr13	23904719	23904719	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttgaaagtgggaggaacaaaGaacctttgagagtaagtctg	13	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:23904719G>C	uc001uon.2	-	10	13885	c.13296C>G	c.(13294-13296)TTC>TTG	p.F4432L	SACS_uc001uoo.2_Missense_Mutation_p.F4285L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4432					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAGGAACAAAGAACCTTTGAG	0.478													0	0	0	0.007835	0	42	112										C	23904719	G	C	23904719	3	2	40	1	0	0	0	0	1	0	0	0	13804	933	33	1	447	1	SACS	13	23904719	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3620994	23904719	91265159	518	10191			4	42		3	3	455	G		5.865231e-05
SACS	26278	broad.mit.edu	37	chr13	23904867	23904867	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgactgaaatcgggatgctGaggttgaaaatgttcgtctg	13	6	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:23904867G>C	uc001uon.2	-	10	13737	c.13148C>G	c.(13147-13149)TCA>TGA	p.S4383*	SACS_uc001uoo.2_Nonsense_Mutation_p.S4236*|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4383	J.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCGGGATGCTGAGGTTGAAAA	0.378													0	0	0	0.009718	0	45	135										C	23904867	G	C	23904867	4	2	40	1	0	0	0	0	0	1	0	0	13804	1294	45	1	595	1	SACS	13	23904867	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	148	23904867	91265011	519	10192			4	42		3	3	455	G		5.865231e-05
SACS	26278	broad.mit.edu	37	chr13	23905173	23905173	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcttgtggctctctctaccaGagaaaagaggaggaatgctt	11	8	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:23905173G>C	uc001uon.2	-	10	13431	c.12842C>G	c.(12841-12843)TCT>TGT	p.S4281C	SACS_uc001uoo.2_Missense_Mutation_p.S4134C|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4281					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTCTCTACCAGAGAAAAGAGG	0.478													0	0	0	0.007291	0	29	84										C	23905173	G	C	23905173	3	2	40	1	0	0	0	0	1	0	0	0	13804	942	33	1	901	1	SACS	13	23905173	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	306	23905173	91264705	520	10193			4	42		3	3	455	G		5.865231e-05
USP12	219333	broad.mit.edu	37	chr13	27645266	27645266	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gactcttaactattgcaataTaatggcctcgattgggacca	8	9	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:27645266T>C	uc001uqy.2	-	8	1206	c.953A>G	c.(952-954)TAT>TGT	p.Y318C		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	318					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TATTGCAATATAATGGCCTCG	0.274													0	0	0	0.001855	0	12	68										C	27645266	T	C	27645266	3	2	40	1	0	0	0	0	1	0	0	0	17040	1406	49	5	167	5	USP12	13	27645266	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	3740093	27645266	87524612	521	10194										
CCNA1	8900	broad.mit.edu	37	chr13	37011849	37011849	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcactccctgactgtggggtCcaagagccccccaagcaagg	12	15	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:37011849C>T	uc001uvr.3	+	3	731	c.381C>T	c.(379-381)GTC>GTT	p.V127V	CCNA1_uc010teo.1_Silent_p.V83V|CCNA1_uc010abq.2_Silent_p.V83V|CCNA1_uc010abp.2_Silent_p.V83V|CCNA1_uc001uvs.3_Silent_p.V126V|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	127					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		ACTGTGGGGTCCAAGAGCCCC	0.498													0	0	0	0.009535	0	32	74										T	37011849	C	T	37011849	2	4	40	1	0	0	0	0	0	0	0	1	2909	842	30	1		1	CCNA1	13	37011849	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9366583	37011849	78158029	522	10195										
CCDC70	83446	broad.mit.edu	37	chr13	52439716	52439716	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaatagaggacttcagggaaGagatgtggactttccgaggc	14	6	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:52439716G>C	uc001vfu.3	+	2	498	c.202G>C	c.(202-204)GAG>CAG	p.E68Q	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	68						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CTTCAGGGAAGAGATGTGGAC	0.468													0	0	0	0.013537	0	12	89										C	52439716	G	C	52439716	3	2	40	1	0	0	0	0	1	0	0	0	2843	943	33	1	204	1	CCDC70	13	52439716	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	15427867	52439716	62730162	523	10196										
TMTC4	84899	broad.mit.edu	37	chr13	101278119	101278119	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aagatatttccaagattattCatggcatgaacatacttggg	8	6	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:101278119C>G	uc001vou.2	-	13	1717	c.1557G>C	c.(1555-1557)ATG>ATC	p.M519I	TMTC4_uc001vot.2_Missense_Mutation_p.M538I|TMTC4_uc010tja.1_Missense_Mutation_p.M408I|TMTC4_uc001vov.1_Missense_Mutation_p.M264I|TMTC4_uc001vow.1_Missense_Mutation_p.M302I	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	519	TPR 3.					integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAAGATTATTCATGGCATGAA	0.343													0	0	0	0.006122	0	16	56										G	101278119	C	G	101278119	3	3	40	1	0	0	0	0	1	0	0	0	16260	826	29	1	692	1	TMTC4	13	101278119	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	48838403	101278119	13891759	524	10197										
COL4A2	1284	broad.mit.edu	37	chr13	111077333	111077333	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttctggattccctggtgccGatggaattcctgtaagtttt	10	8	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:111077333G>A	uc001vqx.2	+	6	638	c.349G>A	c.(349-351)GAT>AAT	p.D117N		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	117					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCCTGGTGCCGATGGAATTCC	0.433													0	0	0	0.00308	0	7	72										A	111077333	G	A	111077333	3	1	40	1	0	0	0	0	1	0	0	0	3690	1058	37	1	367	1	COL4A2	13	111077333	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	9799214	111077333	4092545	525	10198										
C13orf16	121793	broad.mit.edu	37	chr13	111973258	111973258	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atggaatacgtgctggaagtGaagaactctccgcggcacct	12	10	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr13:111973258G>A	uc001vsa.2	+	2	150	c.21G>A	c.(19-21)GTG>GTA	p.V7V		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	7	Extracellular (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			TGCTGGAAGTGAAGAACTCTC	0.652													0	0	0	0.012319	0	18	45										A	111973258	G	A	111973258	2	1	40	1	0	0	0	0	0	0	0	1	1719	1277	45	1		1	C13orf16	13	111973258	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	895925	111973258	3196620	526	10199										
OR4K5	79317	broad.mit.edu	37	chr14	20389242	20389242	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttggtgcacacattaagccaGttatcatttactgtgaacct	7	9	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:20389242G>T	uc010tkw.1	+	1	477	c.477G>T	c.(475-477)CAG>CAT	p.Q159H		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTAAGCCAGTTATCATTTA	0.448													1	0	3.54119e-60	0.01441	3.77242e-60	142	767										T	20389242	G	T	20389242	3	4	40	1	0	0	0	0	1	0	0	0	11073	1020	36	4	479	4	OR4K5	14	20389242	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		20389242	86960298	527	10200										
RPGRIP1	57096	broad.mit.edu	37	chr14	21780010	21780010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaatcctgagtgcagcccatGaggccctcctcaagcaagtg	11	13	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:21780010G>A	uc001wag.2	+	8	958	c.958G>A	c.(958-960)GAG>AAG	p.E320K		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	320	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		TGCAGCCCATGAGGCCCTCCT	0.512													0	0	0	0.000602	0	5	11										A	21780010	G	A	21780010	3	1	40	1	0	0	0	0	1	0	0	0	13549	1291	45	1	988	1	RPGRIP1	14	21780010	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1390768	21780010	85569530	528	10201										
RPGRIP1	57096	broad.mit.edu	37	chr14	21780081	21780081	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcaagaaggctgtgagcttGaagagccaactggaagatgt	14	6	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:21780081G>C	uc001wag.2	+	8	1029	c.1029G>C	c.(1027-1029)TTG>TTC	p.L343F		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	343	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CTGTGAGCTTGAAGAGCCAAC	0.453													0	0	0	0.008291	0	11	11										C	21780081	G	C	21780081	3	2	40	1	0	0	0	0	1	0	0	0	13549	1281	45	1	1059	1	RPGRIP1	14	21780081	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	71	21780081	85569459	529	10202										
FBXO33	254170	broad.mit.edu	37	chr14	39868857	39868857	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tacctgctcaataaggttatGcactggatctacatcctggt	8	10	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:39868857G>A	uc001wvk.2	-	4	1869	c.1531C>T	c.(1531-1533)CAT>TAT	p.H511Y		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	F-box protein 33	511											0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		ATAAGGTTATGCACTGGATCT	0.488													0	0	0	0.008291	0	9	26										A	39868857	G	A	39868857	3	1	40	1	0	0	0	0	1	0	0	0	5743	1319	46	2	140	2	FBXO33	14	39868857	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	18088776	39868857	67480683	530	10203										
FAM179B	23116	broad.mit.edu	37	chr14	45433564	45433564	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagcccaactatctgtacccGaagggtattaagtgcaggaa	10	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:45433564G>A	uc001wvv.2	+	1	2149	c.1940G>A	c.(1939-1941)CGA>CAA	p.R647Q	FAM179B_uc001wvw.2_Missense_Mutation_p.R647Q|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R647Q|FAM179B_uc001wvu.2_Missense_Mutation_p.R647Q	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	647							binding			skin(2)|upper_aerodigestive_tract(1)	3						ATCTGTACCCGAAGGGTATTA	0.443													0	0	0	0.003163	0	16	44										A	45433564	G	A	45433564	3	1	40	1	0	0	0	0	1	0	0	0	5506	1058	37	1	1942	1	FAM179B	14	45433564	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5564707	45433564	61915976	531	10204										
FAM179B	23116	broad.mit.edu	37	chr14	45542646	45542646	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacagccacagctaaattatCaaaagcactctttgcacaga	5	11	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:45542646C>G	uc001wvv.2	+	19	5254	c.5045C>G	c.(5044-5046)TCA>TGA	p.S1682*	FAM179B_uc001wvw.2_Nonsense_Mutation_p.S1735*|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1682							binding			skin(2)|upper_aerodigestive_tract(1)	3						GCTAAATTATCAAAAGCACTC	0.403													0	0	0	0.012319	0	19	58										G	45542646	C	G	45542646	4	3	40	1	0	0	0	0	0	1	0	0	5506	838	29	1	5119	1	FAM179B	14	45542646	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	109082	45542646	61806894	532	10205										
TMX1	81542	broad.mit.edu	37	chr14	51707163	51707163	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggagactggatgatagaattGtgagtgcggggcggccaggg	20	5	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:51707163G>C	uc001wza.3	+	1	277	c.152_splice	c.e1+1	p.F51_splice	TMX1_uc010tqr.1_Splice_Site_p.F51_splice|TMX1_uc010aoa.2_Splice_Site	NM_030755	NP_110382	Q9H3N1	TMX1_HUMAN	thioredoxin domain containing 1 precursor						anti-apoptosis|cell proliferation|cell redox homeostasis|DNA replication|electron transport chain|ER to Golgi vesicle-mediated transport|leukocyte activation|positive regulation of growth|positive regulation of transcription, DNA-dependent|response to stress|signal transduction	endoplasmic reticulum membrane|integral to membrane|membrane fraction	arsenate reductase (thioredoxin) activity|disulfide oxidoreductase activity				0						TGATAGAATTGTGAGTGCGGG	0.647													0	0	0	0.004672	0	3	15										C	51707163	G	C	51707163	5	2	40	1	0	0	0	0	0	0	1	0	16263	1391	48	4	155	4	TMX1	14	51707163	Splice_Site	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6164517	51707163	55642377	533	10206										
ZFP36L1	677	broad.mit.edu	37	chr14	69256711	69256711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggagaggtcccgggccccggCcagggcacggcgctcttcag	17	15	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:69256711C>T	uc001xkh.1	-	2	686	c.556G>A	c.(556-558)GCC>ACC	p.A186T	ZFP36L1_uc001xki.1_Missense_Mutation_p.A186T	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	186					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CGGGCCCCGGCCAGGGCACGG	0.572											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	32										T	69256711	C	T	69256711	3	4	40	1	0	0	0	0	1	0	0	0	17643	739	26	2	464	2	ZFP36L1	14	69256711	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	17549548	69256711	38092829	534	10207										
YLPM1	56252	broad.mit.edu	37	chr14	75231008	75231008	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagagtggggccaaaaacaaGagtactgaacagcagcaagc	13	8	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:75231008G>A	uc001xqj.3	+	1	940	c.816G>A	c.(814-816)AAG>AAA	p.K272K		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCAAAAACAAGAGTACTGAAC	0.532													0	0	0	0.001168	0	5	11										A	75231008	G	A	75231008	2	1	40	1	0	0	0	0	0	0	0	1	17483	933	33	1		1	YLPM1	14	75231008	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5974297	75231008	32118532	535	10208										
C14orf174	161394	broad.mit.edu	37	chr14	77846794	77846794	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aactgctcaaacctccctcaGatggggataacaaactttga	7	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:77846794G>T	uc001xtq.1	+	2	1758	c.1758G>T	c.(1756-1758)CAG>CAT	p.Q586H		NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	586	SAM.										0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		ACCTCCCTCAGATGGGGATAA	0.423													1	0	1.61879e-10	0.013537	1.67783e-10	12	28										T	77846794	G	T	77846794	3	4	40	1	0	0	0	0	1	0	0	0	1759	933	33	3	1764	3	C14orf174	14	77846794	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2615786	77846794	29502746	536	10209										
PTPN21	11099	broad.mit.edu	37	chr14	88946469	88946469	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggtatcacggcgctgtgccGatgggacgggaggtagtcag	19	8	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:88946469G>A	uc001xwv.3	-	13	1637	c.1306C>T	c.(1306-1308)CGG>TGG	p.R436W	PTPN21_uc010twc.1_Missense_Mutation_p.R232W	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	436						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GCGCTGTGCCGATGGGACGGG	0.607													0	0	0	0.006214	0	9	30										A	88946469	G	A	88946469	3	1	40	1	0	0	0	0	1	0	0	0	12786	1057	37	1	2246	1	PTPN21	14	88946469	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	11099675	88946469	18403071	537	10210										
TDP1	55775	broad.mit.edu	37	chr14	90429474	90429474	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtataatgtctcaggaaggcGattatgggaggtggaccata	14	5	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:90429474G>A	uc001xxy.2	+	3	315	c.16G>A	c.(16-18)GAT>AAT	p.D6N	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.D6N|TDP1_uc010atn.2_Missense_Mutation_p.D6N|TDP1_uc001xya.2_5'UTR|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.D6N|TDP1_uc001xyc.1_Missense_Mutation_p.D6N	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	6					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		TCAGGAAGGCGATTATGGGAG	0.433								Repair_of_DNA-protein_crosslinks					0	0	0	0.010504	0	19	69										A	90429474	G	A	90429474	3	1	40	1	0	0	0	0	1	0	0	0	15725	1058	37	1	18	1	TDP1	14	90429474	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1483005	90429474	16920066	538	10211										
CATSPERB	79820	broad.mit.edu	37	chr14	92139220	92139220	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ataaggcctaccttgttataGaagaggtaaactccagtacc	8	9	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:92139220G>T	uc001xzs.1	-	13	1259	c.1119C>A	c.(1117-1119)TTC>TTA	p.F373L	CATSPERB_uc010aub.1_5'Flank	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	373					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CCTTGTTATAGAAGAGGTAAA	0.353													1	0	5.82218e-30	0.01441	6.17249e-30	57	192										T	92139220	G	T	92139220	3	4	40	1	0	0	0	0	1	0	0	0	2691	933	33	3	2291	3	CATSPERB	14	92139220	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1709746	92139220	15210320	539	10212										
PAPOLA	10914	broad.mit.edu	37	chr14	97003330	97003330	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taggtcttgctatcacagatGaaattttgctgagtaaggca	10	6	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:97003330G>A	uc001yfq.2	+	12	1258	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	PAPOLA_uc001yfr.2_Missense_Mutation_p.E350K|PAPOLA_uc010twv.1_Missense_Mutation_p.E350K|PAPOLA_uc010avp.2_Missense_Mutation_p.E100K	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	350					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		TATCACAGATGAAATTTTGCT	0.318													0	0	0	0.010729	0	11	43										A	97003330	G	A	97003330	3	1	40	1	0	0	0	0	1	0	0	0	11429	1291	45	1	1094	1	PAPOLA	14	97003330	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4864110	97003330	10346210	540	10213										
DYNC1H1	1778	broad.mit.edu	37	chr14	102514870	102514870	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taggatcctttgttcaggttCtttgagagagaagtgaagat	12	4	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:102514870C>T	uc001yks.2	+	74	13400	c.13236C>T	c.(13234-13236)TTC>TTT	p.F4412F		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4412					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGTTCAGGTTCTTTGAGAGAG	0.483													0	0	0	0.006214	0	9	37										T	102514870	C	T	102514870	2	4	40	1	0	0	0	0	0	0	0	1	4841	912	32	1		1	DYNC1H1	14	102514870	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5511540	102514870	4834670	541	10214										
KLC1	3831	broad.mit.edu	37	chr14	104121150	104121150	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagatgttggagctcggcctGagtgaggcacaggtacgagt	17	7	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr14:104121150G>A	uc001yno.2	+	2	557	c.249G>A	c.(247-249)CTG>CTA	p.L83L	KLC1_uc010tyd.1_Silent_p.L242L|KLC1_uc010tye.1_Silent_p.L79L|KLC1_uc001ynm.1_Silent_p.L83L|KLC1_uc001ynn.1_Silent_p.L79L|KLC1_uc010tyf.1_Silent_p.L83L	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	83					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				AGCTCGGCCTGAGTGAGGCAC	0.418													0	0	0	0.004482	0	9	53										A	104121150	G	A	104121150	2	1	40	1	0	0	0	0	0	0	0	1	8333	1277	45	1		1	KLC1	14	104121150	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1606280	104121150	3228390	542	10215										
BUB1B	701	broad.mit.edu	37	chr15	40501871	40501871	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caccatggtgttcacagtatCgcagacagctactgaagtcc	9	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:40501871C>T	uc001zkx.3	+	17	2391	c.2179C>T	c.(2179-2181)CGC>TGC	p.R727C		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	727					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTCACAGTATCGCAGACAGCT	0.418			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.005443	0	25	145										T	40501871	C	T	40501871	3	4	40	1	0	0	0	0	1	0	0	0	1571	884	31	1	2245	1	BUB1B	15	40501871	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		40501871	62029521	543	10216										
C15orf52	388115	broad.mit.edu	37	chr15	40633137	40633137	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccctgccggcttcgctgctCagcacacgagatcatgttgt	10	14	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:40633137C>T	uc001zlh.3	-	1	32	c.16G>A	c.(16-18)GAG>AAG	p.E6K	C15orf52_uc001zli.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	6										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTTCGCTGCTCAGCACACGAG	0.647													0	0	0	0.009096	0	3	14										T	40633137	C	T	40633137	3	4	40	1	0	0	0	0	1	0	0	0	1800	835	29	1	1632	1	C15orf52	15	40633137	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	131266	40633137	61898255	544	10217										
MAPKBP1	23005	broad.mit.edu	37	chr15	42107900	42107900	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcctggaggagacaaagctGatgcatccctgttggatccc	12	11	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:42107900G>A	uc001zok.3	+	13	1700	c.1414G>A	c.(1414-1416)GAT>AAT	p.D472N	MAPKBP1_uc001zoj.3_Missense_Mutation_p.D466N|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.D466N|MAPKBP1_uc010udb.1_Missense_Mutation_p.D305N|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	472										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		AGACAAAGCTGATGCATCCCT	0.547													0	0	0	0.001984	0	7	26										A	42107900	G	A	42107900	3	1	40	1	0	0	0	0	1	0	0	0	9292	1290	45	1	1460	1	MAPKBP1	15	42107900	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1474763	42107900	60423492	545	10218										
EHD4	30844	broad.mit.edu	37	chr15	42193072	42193072	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccttcttggcgttgacacctGatatcttgccattgatgggc	10	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:42193072G>C	uc001zot.2	-	6	1460	c.1397C>G	c.(1396-1398)TCA>TGA	p.S466*		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	466	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GTTGACACCTGATATCTTGCC	0.597													0	0	0	0.010729	0	10	51										C	42193072	G	C	42193072	4	2	40	1	0	0	0	0	0	1	0	0	4980	1294	45	1	232	1	EHD4	15	42193072	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	85172	42193072	60338320	546	10219										
CDAN1	146059	broad.mit.edu	37	chr15	43022925	43022925	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccggcgggcctgcagccctCgctgcagcagagtccgcaca	13	18	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:43022925C>T	uc001zql.2	-	14	2162	c.2045G>A	c.(2044-2046)CGA>CAA	p.R682Q	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.E8K	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	682						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTGCAGCCCTCGCTGCAGCAG	0.637													0	0	0	0.00308	0	7	15										T	43022925	C	T	43022925	3	4	40	1	0	0	0	0	1	0	0	0	3054	884	31	1	1698	1	CDAN1	15	43022925	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	829853	43022925	59508467	547	10220										
GATM	2628	broad.mit.edu	37	chr15	45654374	45654374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccagcaatggaagcctcctCccagggaattggcattacga	10	12	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:45654374C>T	uc001zvc.2	-	9	1534	c.1205G>A	c.(1204-1206)GGA>GAA	p.G402E	GATM_uc001zvb.2_Missense_Mutation_p.G273E	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	402					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GAAGCCTCCTCCCAGGGAATT	0.498													0	0	0	0.00308	0	7	53										T	45654374	C	T	45654374	3	4	40	1	0	0	0	0	1	0	0	0	6263	855	30	1	70	1	GATM	15	45654374	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2631449	45654374	56877018	548	10221										
SLC27A2	11001	broad.mit.edu	37	chr15	50518226	50518226	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attaaatatgatgtggagaaAgatgaacctgtccgtgatga	11	4	0	6			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:50518226A>T	uc001zxw.2	+	6	1441	c.1209A>T	c.(1207-1209)AAA>AAT	p.K403N	SLC27A2_uc010bes.2_Missense_Mutation_p.K350N|SLC27A2_uc001zxx.2_Missense_Mutation_p.K168N	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	403	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		ATGTGGAGAAAGATGAACCTG	0.318													0	0	0	0.007835	0	41	104										T	50518226	A	T	50518226	3	4	40	1	0	0	0	0	1	0	0	0	14526	69	3	5	1231	5	SLC27A2	15	50518226	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	4863852	50518226	52013166	549	10222										
MYO5C	55930	broad.mit.edu	37	chr15	52553307	52553307	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggagctcacagaacaccttCaggtgactgtcatcctcctt	8	13	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:52553307C>T	uc010bff.2	-	10	1202	c.1065G>A	c.(1063-1065)CTG>CTA	p.L355L	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_RNA|MYO5C_uc010ugc.1_Silent_p.*255*	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	355	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		AGAACACCTTCAGGTGACTGT	0.572													0	0	0	0.00333	0	22	54										T	52553307	C	T	52553307	2	4	40	1	0	0	0	0	0	0	0	1	10080	813	29	1		1	MYO5C	15	52553307	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2035081	52553307	49978085	550	10223										
RNF111	54778	broad.mit.edu	37	chr15	59344515	59344515	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtttccaggaagtattgatGaagatgttgtggtgatagaa	13	2	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:59344515G>A	uc002afv.2	+	3	1171	c.892G>A	c.(892-894)GAA>AAA	p.E298K	RNF111_uc002afs.2_Missense_Mutation_p.E298K|RNF111_uc002aft.2_Missense_Mutation_p.E298K|RNF111_uc002afu.2_Missense_Mutation_p.E298K|RNF111_uc002afw.2_Missense_Mutation_p.E298K	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	298	Ser-rich.|Interaction with AXIN1.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		AAGTATTGATGAAGATGTTGT	0.373													0	0	0	0.004656	0	28	149										A	59344515	G	A	59344515	3	1	40	1	0	0	0	0	1	0	0	0	13425	1291	45	1	898	1	RNF111	15	59344515	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	6791208	59344515	43186877	551	10224										
HERC1	8925	broad.mit.edu	37	chr15	63984612	63984612	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaggcaaaggacatgtacctGaagaacatttctgagatgct	10	7	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:63984612G>A	uc002amp.2	-	31	5976	c.5828C>T	c.(5827-5829)TCA>TTA	p.S1943L		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1943					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ACATGTACCTGAAGAACATTT	0.358													0	0	0	0.007413	0	18	88										A	63984612	G	A	63984612	3	1	40	1	0	0	0	0	1	0	0	0	7057	1294	45	1	8949	1	HERC1	15	63984612	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4640097	63984612	38546780	552	10225										
RASL12	51285	broad.mit.edu	37	chr15	65347506	65347506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgtgcctctcgcactgcctCgtggaagacatgctgcacgt	11	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:65347506C>T	uc002aoi.1	-	5	747	c.532G>A	c.(532-534)GAG>AAG	p.E178K	RASL12_uc002aoj.1_Missense_Mutation_p.E159K|RASL12_uc010uir.1_Missense_Mutation_p.E167K	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	178					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						CGCACTGCCTCGTGGAAGACA	0.647													0	0	0	0.004482	0	7	29										T	65347506	C	T	65347506	3	4	40	1	0	0	0	0	1	0	0	0	13083	893	31	1	272	1	RASL12	15	65347506	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1362894	65347506	37183886	553	10226										
FEM1B	10116	broad.mit.edu	37	chr15	68582398	68582398	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaaagctgtaaagctgatgtCgtagaactgttactctctca	9	8	2	2	rs142803256		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:68582398C>T	uc002arg.2	+	2	1317	c.702C>T	c.(700-702)GTC>GTT	p.V234V	FEM1B_uc002arh.2_Silent_p.V154V	NM_015322	NP_056137	Q9UK73	FEM1B_HUMAN	fem-1 homolog b	234	ANK 6.				apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity				0						AAGCTGATGTCGTAGAACTGT	0.458													0	0	0	0.003755	0	36	466										T	68582398	C	T	68582398	2	4	40	1	0	0	0	0	0	0	0	1	5810	871	31	1		1	FEM1B	15	68582398	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3234892	68582398	33948994	554	10227										
ITGA11	22801	broad.mit.edu	37	chr15	68600001	68600001	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggggaccagccgtatattgcAgttgatggagacgacatcag	14	8	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:68600001A>G	uc002ari.2	-	27	3295	c.3208T>C	c.(3208-3210)TGC>CGC	p.C1070R	ITGA11_uc010bib.2_Missense_Mutation_p.C1071R	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	1070	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CGTATATTGCAGTTGATGGAG	0.542													0	0	0	0.01441	0	62	22										G	68600001	A	G	68600001	3	3	40	1	0	0	0	0	1	0	0	0	7874	188	7	5	374	5	ITGA11	15	68600001	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	17603	68600001	33931391	555	10228										
THAP10	56906	broad.mit.edu	37	chr15	71174897	71174897	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgaatcactggagtaaatgtCaaagagagaggaagttctag	12	4	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:71174897C>T	uc002asv.2	-	3	812	c.670G>A	c.(670-672)GAC>AAC	p.D224N	LRRC49_uc002asu.2_Intron	NM_020147	NP_064532	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	224							DNA binding|metal ion binding			ovary(1)|skin(1)	2						GAGTAAATGTCAAAGAGAGAG	0.393													0	0	0	0.013726	0	34	187										T	71174897	C	T	71174897	3	4	40	1	0	0	0	0	1	0	0	0	15839	826	29	1	107	1	THAP10	15	71174897	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2574896	71174897	31356495	556	10229										
PML	5371	broad.mit.edu	37	chr15	74336969	74336969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcgtgacctgtgccgcctcCtcgaggtctccccgggcccc	12	19	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:74336969C>T	uc002awv.2	+	9	2409	c.2269C>T	c.(2269-2271)CTC>TTC	p.L757F	PML_uc002awu.2_Missense_Mutation_p.L709F|PML_uc010ule.1_Missense_Mutation_p.L318F	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	757					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						GTGCCGCCTCCTCGAGGTCTC	0.652			T	RARA|PAX5	APL|ALL								0	0	0	0.000602	0	4	23										T	74336969	C	T	74336969	3	4	40	1	0	0	0	0	1	0	0	0	12135	681	24	2	3320	2	PML	15	74336969	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3162072	74336969	28194423	557	10230										
FANCI	55215	broad.mit.edu	37	chr15	89834895	89834895	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgctgcctcctctgaaattaGaagcttgtattctgacccaa	7	11	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:89834895G>C	uc010bnp.1	+	20	2032	c.1942G>C	c.(1942-1944)GAA>CAA	p.E648Q	FANCI_uc002bnm.1_Missense_Mutation_p.E648Q|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.E469Q|FANCI_uc002bnq.1_Missense_Mutation_p.E61Q	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	648					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCTGAAATTAGAAGCTTGTAT	0.353								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00874	0	38	161										C	89834895	G	C	89834895	3	2	40	1	0	0	0	0	1	0	0	0	5669	943	33	1	2016	1	FANCI	15	89834895	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	15497926	89834895	12696497	558	10231										
C15orf42	90381	broad.mit.edu	37	chr15	90161397	90161397	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcgaggtcctctgatcctgGtcctgatattggtgttgttg	12	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:90161397G>C	uc002boe.2	+	17	2975	c.2975G>C	c.(2974-2976)GGT>GCT	p.G992A		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	992					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TCTGATCCTGGTCCTGATATT	0.413													0	0	0	0.01441	0	157	269										C	90161397	G	C	90161397	3	2	40	1	0	0	0	0	1	0	0	0	1796	1261	44	4	3041	4	C15orf42	15	90161397	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	326502	90161397	12369995	559	10232										
AP3S2	10239	broad.mit.edu	37	chr15	90431850	90431850	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggtagatcagtttgtagtcaGagccaccaatcaaactgcag	10	9	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:90431850G>A	uc002boq.3	-	3	612	c.176C>T	c.(175-177)TCT>TTT	p.S59F	AP3S2_uc002bos.3_Missense_Mutation_p.S260F|AP3S2_uc010bns.2_RNA|AP3S2_uc002bor.3_RNA|AP3S2_uc010bnt.2_Intron	NM_005829	NP_005820	P59780	AP3S2_HUMAN	adaptor-related protein complex 3, sigma 2	59					intracellular protein transport|vesicle-mediated transport	cytoplasmic vesicle membrane|Golgi apparatus|membrane coat	protein transporter activity				0	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)			TTTGTAGTCAGAGCCACCAAT	0.418													0	0	0	0.009096	0	3	35										A	90431850	G	A	90431850	3	1	40	1	0	0	0	0	1	0	0	0	750	942	33	1	421	1	AP3S2	15	90431850	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	270453	90431850	12099542	560	10233										
CHD2	1106	broad.mit.edu	37	chr15	93558043	93558043	+	Nonsense_Mutation	SNP	C	C	T													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctcacacaaccttcaccctCagaagcctcatttgcctgcc							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:93558043C>T	uc002bsp.2	+	37	5385	c.4810C>T	c.(4810-4812)CAG>TAG	p.Q1604*	CHD2_uc002bso.1_Nonsense_Mutation_p.Q1604*	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1604					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CCTTCACCCTCAGAAGCCTCA	0.532													0	0	0	0.00333	0	22	170										T	93558043	C	T	93558043	4	4	40	1	0	0	0	0	0	1	0	0	3325	827	29	1	4956	1	CHD2	15	93558043	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3126193	93558043	8973349	561	10234	50	2								
CHD2	1106	broad.mit.edu	37	chr15	93558052	93558052	+	Missense_Mutation	SNP	C	C	T													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accttcaccctcagaagcctCatttgcctgcctcccatggc							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr15:93558052C>T	uc002bsp.2	+	37	5394	c.4819C>T	c.(4819-4821)CAT>TAT	p.H1607Y	CHD2_uc002bso.1_Missense_Mutation_p.H1607Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1607					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TCAGAAGCCTCATTTGCCTGC	0.517													0	0	0	0.005443	0	25	174										T	93558052	C	T	93558052	3	4	40	1	0	0	0	0	1	0	0	0	3325	826	29	1	4965	1	CHD2	15	93558052	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9	93558052	8973340	562	10235	50	2								
AXIN1	8312	broad.mit.edu	37	chr16	339566	339566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccacaacgatgctgtcacacGgctgggcactcccgccgccc	10	19	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:339566G>A	uc002cgp.1	-	10	2513	c.2336C>T	c.(2335-2337)CCG>CTG	p.P779L	AXIN1_uc002cgq.1_Missense_Mutation_p.P743L	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	779	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				GCTGTCACACGGCTGGGCACT	0.637													0	0	0	0.001168	0	6	34										A	339566	G	A	339566	3	1	40	1	0	0	0	0	1	0	0	0	1236	1116	39	2	260	2	AXIN1	16	339566	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		339566	90015187	563	10236										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1797074	1797074	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcaggccagtcctcggcggcCgccacacccagcaccacagg	11	19	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:1797074C>T	uc002cmk.2	+	6	909	c.789C>T	c.(787-789)GCC>GCT	p.A263A	MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Silent_p.A263A|MAPK8IP3_uc010uvl.1_Silent_p.A264A	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	263					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCTCGGCGGCCGCCACACCCA	0.667													0	0	0	0.000602	0	3	21										T	1797074	C	T	1797074	2	4	40	1	0	0	0	0	0	0	0	1	9286	639	23	2		2	MAPK8IP3	16	1797074	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1457508	1797074	88557679	564	10237										
OR2C1	4993	broad.mit.edu	37	chr16	3406140	3406140	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttcttcctcagcaacctctCctccttggaccttgctttcg	5	17	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:3406140C>G	uc002cuw.1	+	1	252	c.200C>G	c.(199-201)TCC>TGC	p.S67C		NM_012368	NP_036500	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGCAACCTCTCCTCCTTGGAC	0.522													0	0	0	0.006999	0	37	161										G	3406140	C	G	3406140	3	3	40	1	0	0	0	0	1	0	0	0	10992	855	30	1	202	1	OR2C1	16	3406140	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1609066	3406140	86948613	565	10238										
CREBBP	1387	broad.mit.edu	37	chr16	3807965	3807965	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccagacgtcgtccacgtactGccagggctcttggtattgcc	11	14	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:3807965G>A	uc002cvv.2	-	18	3658	c.3454C>T	c.(3454-3456)CAG>TAG	p.Q1152*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.Q1114*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1152	Bromo.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TCCACGTACTGCCAGGGCTCT	0.458			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.004007	0	16	65										A	3807965	G	A	3807965	4	1	40	1	0	0	0	0	0	1	0	0	3861	1328	46	2	3930	2	CREBBP	16	3807965	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	401825	3807965	86546788	566	10239										
ITPRIPL2	162073	broad.mit.edu	37	chr16	19126049	19126049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggtcacgccgccttctcctCgagacacttccgagagccgg	12	16	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:19126049C>T	uc002dfu.3	+	1	796	c.266C>T	c.(265-267)TCG>TTG	p.S89L	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	89	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GCCTTCTCCTCGAGACACTTC	0.662													0	0	0	0.001168	0	5	14										T	19126049	C	T	19126049	3	4	40	1	0	0	0	0	1	0	0	0	7925	893	31	1	268	1	ITPRIPL2	16	19126049	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	15318084	19126049	71228704	567	10240										
TAOK2	9344	broad.mit.edu	37	chr16	29998037	29998037	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttggagcccaagcagcagaGgattctgggggaagaatcag	15	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:29998037G>A	uc002dva.1	+	16	3227	c.2444G>A	c.(2443-2445)AGG>AAG	p.R815K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.R822K|TAOK2_uc002dvd.1_Missense_Mutation_p.R642K	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	815	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						AAGCAGCAGAGGATTCTGGGG	0.552													0	0	0	0.008291	0	10	76										A	29998037	G	A	29998037	3	1	40	1	0	0	0	0	1	0	0	0	15545	1000	35	2	2502	2	TAOK2	16	29998037	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10871988	29998037	60356716	568	10241										
ZNF689	115509	broad.mit.edu	37	chr16	30620909	30620909	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcagccggttcccagtcatCggtgtttcgttccaaccagg	11	13	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:30620909C>T	uc002dyx.2	-	2	576	c.256G>A	c.(256-258)GAT>AAT	p.D86N	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	86	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			TCCCAGTCATCGGTGTTTCGT	0.567													0	0	0	0.008291	0	9	53										T	30620909	C	T	30620909	3	4	40	1	0	0	0	0	1	0	0	0	18091	884	31	1	1254	1	ZNF689	16	30620909	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	622872	30620909	59733844	569	10242										
SRCAP	10847	broad.mit.edu	37	chr16	30735080	30735080	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccccatctctgtccccacCacacttcctgccccagcctc	3	24	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:30735080C>T	uc002dze.1	+	25	4720	c.4335C>T	c.(4333-4335)ACC>ACT	p.T1445T	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.T1240T|SRCAP_uc010bzz.1_Silent_p.T1015T	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1445	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTGTCCCCACCACACTTCCTG	0.567													0	0	0	0.009535	0	32	118										T	30735080	C	T	30735080	2	4	40	1	0	0	0	0	0	0	0	1	15134	581	21	2		2	SRCAP	16	30735080	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	114171	30735080	59619673	570	10243										
ABCC12	94160	broad.mit.edu	37	chr16	48177901	48177901	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcctttgccggtagcctttCaccatcaccggcgtgagcca	10	15	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:48177901C>T	uc002efc.1	-	2	541	c.195G>A	c.(193-195)GTG>GTA	p.V65V	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Silent_p.V65V|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	65						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				GGTAGCCTTTCACCATCACCG	0.552													0	0	0	0.010729	0	12	163										T	48177901	C	T	48177901	2	4	40	1	0	0	0	0	0	0	0	1	52	813	29	1		1	ABCC12	16	48177901	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	17442821	48177901	42176852	571	10244										
ADCY7	113	broad.mit.edu	37	chr16	50339495	50339495	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	attgaggggctcagctccacGaggtgaggtctgagacctct	14	10	3	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:50339495G>A	uc002egd.1	+	12	1945	c.1677G>A	c.(1675-1677)ACG>ACA	p.T559T	ADCY7_uc002egc.1_Silent_p.T559T	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	559	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TCAGCTCCACGAGGTGAGGTC	0.612													0	0	0	0.01441	0	53	88										A	50339495	G	A	50339495	2	1	40	1	0	0	0	0	0	0	0	1	299	1045	37	1		1	ADCY7	16	50339495	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2161594	50339495	40015258	572	10245										
ADCY7	113	broad.mit.edu	37	chr16	50339739	50339739	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acctttgggtccatcttcctGgagaagggctttgagcgcga	13	10	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:50339739G>A	uc002egd.1	+	13	1999	c.1731G>A	c.(1729-1731)CTG>CTA	p.L577L	ADCY7_uc002egc.1_Silent_p.L577L	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	577	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CCATCTTCCTGGAGAAGGGCT	0.672													0	0	0	0.010818	0	30	44										A	50339739	G	A	50339739	2	1	40	1	0	0	0	0	0	0	0	1	299	1335	47	2		2	ADCY7	16	50339739	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	244	50339739	40015014	573	10246										
BRD7	29117	broad.mit.edu	37	chr16	50383964	50383964	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctatggactgatagtcattGttcttgatcttttctttcat	6	7	6	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:50383964G>A	uc002egf.1	-	6	628	c.561C>T	c.(559-561)AAC>AAT	p.N187N	BRD7_uc002ege.1_Silent_p.N187N	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	187	Bromo.				cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				GATAGTCATTGTTCTTGATCT	0.343													0	0	0	0.01441	0	86	121										A	50383964	G	A	50383964	2	1	40	1	0	0	0	0	0	0	0	1	1505	1368	48	2		2	BRD7	16	50383964	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	44225	50383964	39970789	574	10247										
PRSS54	221191	broad.mit.edu	37	chr16	58314274	58314274	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	taagggttgtacagacgcctCaggagacctgcctgattcct	11	11	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:58314274C>T	uc002enf.2	-	7	1437	c.1042G>A	c.(1042-1044)GAG>AAG	p.E348K	PRSS54_uc002eng.2_Missense_Mutation_p.E348K|PRSS54_uc010vie.1_Missense_Mutation_p.E249K|CCDC113_uc002ene.2_3'UTR|CCDC113_uc010vid.1_3'UTR	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	348					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ACAGACGCCTCAGGAGACCTG	0.478													0	0	0	0.012319	0	22	63										T	58314274	C	T	58314274	3	4	40	1	0	0	0	0	1	0	0	0	12633	835	29	1	149	1	PRSS54	16	58314274	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7930310	58314274	32040479	575	10248										
RRAD	6236	broad.mit.edu	37	chr16	66957559	66957559	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agctgcccttgtccgtcactGagtacacaatgacataggca	9	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:66957559G>A	uc002eqn.2	-	4	661	c.509C>T	c.(508-510)TCA>TTA	p.S170L	RRAD_uc002eqo.2_Missense_Mutation_p.S170L	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	170					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GTCCGTCACTGAGTACACAAT	0.607													0	0	0	0.00278	0	22	69										A	66957559	G	A	66957559	3	1	40	1	0	0	0	0	1	0	0	0	13671	1294	45	1	425	1	RRAD	16	66957559	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	8643285	66957559	23397194	576	10249										
CES2	8824	broad.mit.edu	37	chr16	66976646	66976646	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgaaggcagaccatggtgatGagcttccttttgttttcaga	11	7	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:66976646G>A	uc002eqr.2	+	10	2570	c.1570G>A	c.(1570-1572)GAG>AAG	p.E524K	CES2_uc002eqq.2_Intron|CES2_uc002eqs.2_Missense_Mutation_p.E367K	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	460					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCATGGTGATGAGCTTCCTTT	0.552													0	0	0	0.010729	0	11	51										A	66976646	G	A	66976646	3	1	40	1	0	0	0	0	1	0	0	0	3270	1291	45	1	1608	1	CES2	16	66976646	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	19087	66976646	23378107	577	10250										
RLTPR	146206	broad.mit.edu	37	chr16	67683380	67683380	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctctgtcggtggctgagtctCggctgaagctgggtgccagc	16	11	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:67683380C>T	uc002etn.2	+	20	1897	c.1777C>T	c.(1777-1779)CGG>TGG	p.R593W	RLTPR_uc010cel.1_Missense_Mutation_p.R586W|RLTPR_uc010vjr.1_Missense_Mutation_p.R557W	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	593	Tropomodulin-like.|LRR 13.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGCTGAGTCTCGGCTGAAGCT	0.632													0	0	0	0.00308	0	6	26										T	67683380	C	T	67683380	3	4	40	1	0	0	0	0	1	0	0	0	13394	875	31	1	1855	1	RLTPR	16	67683380	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	706734	67683380	22671373	578	10251										
TSNAXIP1	55815	broad.mit.edu	37	chr16	67859121	67859121	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctgtaagatcctcatcgcaGacctgaatgagctgcggtac	10	12	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:67859121G>A	uc002euj.2	+	7	992	c.598G>A	c.(598-600)GAC>AAC	p.D200N	TSNAXIP1_uc010cep.2_Missense_Mutation_p.D64N|TSNAXIP1_uc010vjz.1_Missense_Mutation_p.D77N|TSNAXIP1_uc002euf.3_5'UTR|TSNAXIP1_uc010vka.1_Missense_Mutation_p.D254N|TSNAXIP1_uc010vkb.1_Missense_Mutation_p.D185N|TSNAXIP1_uc002eug.3_5'UTR|TSNAXIP1_uc002euh.3_5'UTR|TSNAXIP1_uc002eui.3_5'UTR|TSNAXIP1_uc002euk.2_5'UTR	NM_018430	NP_060900	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein	200					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm					0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		CCTCATCGCAGACCTGAATGA	0.542													0	0	0	0.00245	0	15	45										A	67859121	G	A	67859121	3	1	40	1	0	0	0	0	1	0	0	0	16629	942	33	1	616	1	TSNAXIP1	16	67859121	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	175741	67859121	22495632	579	10252										
SLC12A4	6560	broad.mit.edu	37	chr16	67985184	67985184	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctccacgatgtcacccttctCcaggtaggcgctccacaggt	9	16	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:67985184C>T	uc002euz.2	-	9	1297	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	SLC12A4_uc010ceu.2_Missense_Mutation_p.E380K|SLC12A4_uc010vkh.1_Missense_Mutation_p.E355K|SLC12A4_uc010vki.1_Missense_Mutation_p.E386K|SLC12A4_uc010vkj.1_Missense_Mutation_p.E388K|SLC12A4_uc002eva.2_Missense_Mutation_p.E386K|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	386	Cytoplasmic (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCACCCTTCTCCAGGTAGGCG	0.632													0	0	0	0.014323	0	22	76										T	67985184	C	T	67985184	3	4	40	1	0	0	0	0	1	0	0	0	14385	864	30	1	2165	1	SLC12A4	16	67985184	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	126063	67985184	22369569	580	10253										
HP	3240	broad.mit.edu	37	chr16	72094456	72094456	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttaaatttactgaccatctGaagtatgtcatgctgcctgt	7	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:72094456G>A	uc002fbr.3	+	7	932	c.888G>A	c.(886-888)CTG>CTA	p.L296L	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.L237L|HP_uc002fbt.3_Silent_p.L237L|HP_uc002fbu.1_Silent_p.L34L|HP_uc002fbv.3_Silent_p.L207L|HP_uc002fbw.3_Silent_p.L118L|HP_uc002fbx.3_Silent_p.L118L|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	296	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		CTGACCATCTGAAGTATGTCA	0.493													0	0	0	0.00245	0	15	36										A	72094456	G	A	72094456	2	1	40	1	0	0	0	0	0	0	0	1	7327	1277	45	1		1	HP	16	72094456	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4109272	72094456	18260297	581	10254										
HPR	3250	broad.mit.edu	37	chr16	72108235	72108235	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatggctatgtggagcacttGtttcgctaccagtgtaagaa	11	7	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:72108235G>C	uc002fby.2	+	3	174	c.144G>C	c.(142-144)TTG>TTC	p.L48F	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	48	Sushi.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TGGAGCACTTGTTTCGCTACC	0.493													0	0	0	0.013537	0	13	63										C	72108235	G	C	72108235	3	2	40	1	0	0	0	0	1	0	0	0	7337	1368	48	4	154	4	HPR	16	72108235	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	13779	72108235	18246518	582	10255										
ADAMTS18	170692	broad.mit.edu	37	chr16	77325188	77325188	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccacggcaatgaataccatCcagctaccatgttgtacact	7	13	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:77325188C>A	uc002ffc.3	-	21	3796	c.3377G>T	c.(3376-3378)GGA>GTA	p.G1126V		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1126	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGAATACCATCCAGCTACCAT	0.502													1	0	0.00198382	0.001984	0.0020089	5	77										A	77325188	C	A	77325188	3	1	40	1	0	0	0	0	1	0	0	0	263	855	30	3	300	3	ADAMTS18	16	77325188	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5216953	77325188	13029565	583	10256										
ATP2C2	9914	broad.mit.edu	37	chr16	84473071	84473071	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gttctgacaagacggggactCtgactgccaatgaaatgaca	11	9	2	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:84473071C>T	uc002fhx.2	+	13	1239	c.1150C>T	c.(1150-1152)CTG>TTG	p.L384L	ATP2C2_uc010chj.2_Silent_p.L384L|ATP2C2_uc002fhy.2_Silent_p.L401L|ATP2C2_uc002fhz.2_Silent_p.L233L	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	384	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GACGGGGACTCTGACTGCCAA	0.502													0	0	0	0.01441	0	52	205										T	84473071	C	T	84473071	2	4	40	1	0	0	0	0	0	0	0	1	1144	912	32	1		1	ATP2C2	16	84473071	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7147883	84473071	5881682	584	10257										
ZCCHC14	23174	broad.mit.edu	37	chr16	87445991	87445991	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatcagcaggaacagatgacGacagcagcagtttgatgggc	13	8	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:87445991G>C	uc002fjz.1	-	12	1952	c.1925C>G	c.(1924-1926)TCG>TGG	p.S642W	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.S418W	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	642					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		AACAGATGACGACAGCAGCAG	0.592													0	0	0	0.005443	0	29	109										C	87445991	G	C	87445991	3	2	40	1	0	0	0	0	1	0	0	0	17580	1059	37	1	932	1	ZCCHC14	16	87445991	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2972920	87445991	2908762	585	10258										
ZCCHC14	23174	broad.mit.edu	37	chr16	87446150	87446150	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctttggtccggggaccaaagGagactgtgggtgacatggag	17	7	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr16:87446150G>C	uc002fjz.1	-	12	1793	c.1766C>G	c.(1765-1767)TCC>TGC	p.S589C	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.S365C	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	589					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GGGACCAAAGGAGACTGTGGG	0.657													0	0	0	0.00308	0	8	46										C	87446150	G	C	87446150	3	2	40	1	0	0	0	0	1	0	0	0	17580	1174	41	1	1091	1	ZCCHC14	16	87446150	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	159	87446150	2908603	586	10259										
MYO1C	4641	broad.mit.edu	37	chr17	1371362	1371362	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgttgggcgtgagcagcagcTgccgggagcgaggcttgtag	19	9	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:1371362T>C	uc002fsp.2	-	28	3036	c.2816A>G	c.(2815-2817)CAG>CGG	p.Q939R	MYO1C_uc002fsn.2_Missense_Mutation_p.Q920R|MYO1C_uc002fso.2_Missense_Mutation_p.Q904R|MYO1C_uc010vqj.1_Missense_Mutation_p.Q904R	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	939					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GAGCAGCAGCTGCCGGGAGCG	0.627													0	0	0	0.008291	0	7	39										C	1371362	T	C	1371362	3	2	40	1	0	0	0	0	1	0	0	0	10070	1580	55	5	395	5	MYO1C	17	1371362	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08		1371362	79823848	587	10260										
PRPF8	10594	broad.mit.edu	37	chr17	1576684	1576684	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttccagaccccgtccttgtgGgtgaactcctcatagctggt	10	13	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:1576684G>T	uc002fte.2	-	23	3738	c.3624C>A	c.(3622-3624)ACC>ACA	p.T1208T		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1208						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CGTCCTTGTGGGTGAACTCCT	0.587													1	0	2.0095e-06	0.001984	2.05857e-06	7	36										T	1576684	G	T	1576684	2	4	40	1	0	0	0	0	0	0	0	1	12575	1219	43	4		4	PRPF8	17	1576684	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	205322	1576684	79618526	588	10261										
PRPF8	10594	broad.mit.edu	37	chr17	1576731	1576731	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttaggcaggatgcggcactCgaagccacacatgttgaaca	11	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:1576731C>T	uc002fte.2	-	23	3691	c.3577G>A	c.(3577-3579)GAG>AAG	p.E1193K		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1193						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		ATGCGGCACTCGAAGCCACAC	0.577													0	0	0	0.008871	0	19	61										T	1576731	C	T	1576731	3	4	40	1	0	0	0	0	1	0	0	0	12575	893	31	1	3514	1	PRPF8	17	1576731	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	47	1576731	79618479	589	10262										
KIAA0664	23277	broad.mit.edu	37	chr17	2597243	2597243	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcgggcgaggaggcgcaggCaggcgcaggtctccacgtgc	20	12	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:2597243C>T	uc002fuy.1	-	19	3151	c.3065G>A	c.(3064-3066)TGC>TAC	p.C1022Y	KIAA0664_uc002fux.1_Missense_Mutation_p.C955Y|KIAA0664_uc010ckc.1_Missense_Mutation_p.C8Y	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1022	TPR 2.						binding			breast(2)	2						GAGGCGCAGGCAGGCGCAGGT	0.627													0	0	0	0.001984	0	6	10										T	2597243	C	T	2597243	3	4	40	1	0	0	0	0	1	0	0	0	8189	710	25	2	896	2	KIAA0664	17	2597243	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1020512	2597243	78597967	590	10263										
ATP2A3	489	broad.mit.edu	37	chr17	3856676	3856676	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agccagcagcaggatgcgcaCcaggaggtcctcaaactgtt	12	12	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:3856676C>T	uc002fxb.1	-	3	335	c.184G>A	c.(184-186)GTG>ATG	p.V62M	ATP2A3_uc002fwx.1_Missense_Mutation_p.V62M|ATP2A3_uc002fwy.1_Missense_Mutation_p.V62M|ATP2A3_uc002fwz.1_Missense_Mutation_p.V62M|ATP2A3_uc002fxa.1_Missense_Mutation_p.V62M|ATP2A3_uc002fxc.1_Missense_Mutation_p.V62M|ATP2A3_uc002fxd.1_Missense_Mutation_p.V62M	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	62	Helical; Name=1; (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		AGGATGCGCACCAGGAGGTCC	0.647													0	0	0	0.00308	0	7	61										T	3856676	C	T	3856676	3	4	40	1	0	0	0	0	1	0	0	0	1138	507	18	2	3102	2	ATP2A3	17	3856676	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1259433	3856676	77338534	591	10264										
ANKFY1	51479	broad.mit.edu	37	chr17	4086695	4086695	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agagcggcttcctcctacctGacatttatatctgcctggtg	9	12	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:4086695G>A	uc002fxq.1	-	14	1988	c.1950C>T	c.(1948-1950)GTC>GTT	p.V650V	ANKFY1_uc002fxn.2_Silent_p.V692V|ANKFY1_uc002fxo.2_Silent_p.V650V|ANKFY1_uc002fxp.2_Silent_p.V649V|ANKFY1_uc010ckp.2_Silent_p.V591V	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	650	ANK 9.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						CCTCCTACCTGACATTTATAT	0.488													0	0	0	0.00333	0	22	89										A	4086695	G	A	4086695	2	1	40	1	0	0	0	0	0	0	0	1	626	1277	45	1		1	ANKFY1	17	4086695	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	230019	4086695	77108515	592	10265										
GGT6	124975	broad.mit.edu	37	chr17	4462916	4462916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgggagtgtccgccgggtgGaggggccacagagcccaagc	19	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:4462916G>A	uc002fyd.3	-	2	340	c.280C>T	c.(280-282)CCA>TCA	p.P94S	GGT6_uc010vsb.1_5'UTR|GGT6_uc002fyc.3_Missense_Mutation_p.P94S|GGT6_uc010vsc.1_Missense_Mutation_p.P94S	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	94	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1						CCGCCGGGTGGAGGGGCCACA	0.677													0	0	0	0.008291	0	11	16										A	4462916	G	A	4462916	3	1	40	1	0	0	0	0	1	0	0	0	6363	1174	41	1	1213	1	GGT6	17	4462916	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	376221	4462916	76732294	593	10266										
ZNF594	84622	broad.mit.edu	37	chr17	5086687	5086687	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gaggggtttctctccagtgtGaattctctgatgtgggacaa	13	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:5086687G>A	uc010cla.1	-	2	1021	c.865C>T	c.(865-867)CAC>TAC	p.H289Y		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	289	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCTCCAGTGTGAATTCTCTGA	0.433													0	0	0	0.012319	0	21	154										A	5086687	G	A	5086687	3	1	40	1	0	0	0	0	1	0	0	0	18021	1290	45	1	1562	1	ZNF594	17	5086687	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	623771	5086687	76108523	594	10267										
NLRP1	22861	broad.mit.edu	37	chr17	5462822	5462822	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agccgctctggcctagacagGatctgtctaatgggagccgg	14	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:5462822G>A	uc002gci.2	-	4	1749	c.1194C>T	c.(1192-1194)ATC>ATT	p.I398I	NLRP1_uc002gcg.1_Silent_p.I398I|NLRP1_uc002gck.2_Silent_p.I398I|NLRP1_uc002gcj.2_Silent_p.I398I|NLRP1_uc002gcl.2_Silent_p.I398I|NLRP1_uc002gch.3_Silent_p.I398I|NLRP1_uc010clh.2_Silent_p.I398I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	398	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCCTAGACAGGATCTGTCTAA	0.577													0	0	0	0.004482	0	6	38										A	5462822	G	A	5462822	2	1	40	1	0	0	0	0	0	0	0	1	10471	1164	41	1		1	NLRP1	17	5462822	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	376135	5462822	75732388	595	10268										
SLC13A5	284111	broad.mit.edu	37	chr17	6610016	6610016	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagggcgatcctcttgtgcaGgttccagcgctccacagcca	11	15	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:6610016G>C	uc002gdj.2	-	3	401	c.313C>G	c.(313-315)CTG>GTG	p.L105V	SLC13A5_uc010vtf.1_Missense_Mutation_p.L105V|SLC13A5_uc010clq.2_Missense_Mutation_p.L62V|SLC13A5_uc002gdk.2_Missense_Mutation_p.L105V|SLC13A5_uc002gdl.1_5'Flank	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	105						integral to membrane	citrate transmembrane transporter activity				0						CTCTTGTGCAGGTTCCAGCGC	0.627													0	0	0	0.009096	0	3	26										C	6610016	G	C	6610016	3	2	40	1	0	0	0	0	1	0	0	0	14395	991	35	4	1433	4	SLC13A5	17	6610016	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1147194	6610016	74585194	596	10269										
BCL6B	255877	broad.mit.edu	37	chr17	6930283	6930283	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcccaggtggcacatctgcgGgcgcacgtgctgatccacac	12	15	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:6930283G>C	uc002geg.2	+	8	1257	c.1200G>C	c.(1198-1200)CGG>CGC	p.R400R	BCL6B_uc010clt.1_Silent_p.R401R	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	400	C2H2-type 3.					nucleus	zinc ion binding			skin(1)	1						CACATCTGCGGGCGCACGTGC	0.632													0	0	0	0.008291	0	11	56										C	6930283	G	C	6930283	2	2	40	1	0	0	0	0	0	0	0	1	1377	1219	43	4		4	BCL6B	17	6930283	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	320267	6930283	74264927	597	10270										
C17orf81	23587	broad.mit.edu	37	chr17	7160258	7160258	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccaggccctgtgggagctctCagcagccttgctcagactga	12	14	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7160258C>T	uc002gfg.1	+	6	647	c.540C>T	c.(538-540)CTC>CTT	p.L180L	C17orf81_uc002gfj.2_Silent_p.L180L|C17orf81_uc010cmb.2_Silent_p.L180L|C17orf81_uc002gfh.1_Silent_p.L180L|C17orf81_uc002gfi.1_Silent_p.L180L|C17orf81_uc002gfl.1_Silent_p.L180L	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						TGGGAGCTCTCAGCAGCCTTG	0.617													0	0	0	0.00245	0	13	29										T	7160258	C	T	7160258	2	4	40	1	0	0	0	0	0	0	0	1	1886	813	29	1		1	C17orf81	17	7160258	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	229975	7160258	74034952	598	10271										
GPS2	2874	broad.mit.edu	37	chr17	7217447	7217447	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgaacagtcaggctctgctGgtatgcagctgatgttaggg	15	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7217447G>A	uc002gfv.1	-	4	612	c.349C>T	c.(349-351)CAG>TAG	p.Q117*	GPS2_uc002gfw.1_Nonsense_Mutation_p.Q79*|GPS2_uc002gfx.1_Nonsense_Mutation_p.Q117*|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Nonsense_Mutation_p.Q117*	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	117					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				AGGCTCTGCTGGTATGCAGCT	0.507													0	0	0	0.010818	0	31	148										A	7217447	G	A	7217447	4	1	40	1	0	0	0	0	0	1	0	0	6733	1357	47	2	662	2	GPS2	17	7217447	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	57189	7217447	73977763	599	10272										
ACAP1	9744	broad.mit.edu	37	chr17	7250445	7250445	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggagtcgggcacgtggtggcCcaggtccagagtgtggatgg	20	8	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7250445C>T	uc002ggd.2	+	14	1433	c.1227C>T	c.(1225-1227)GCC>GCT	p.A409A		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	409	Arf-GAP.|Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						ACGTGGTGGCCCAGGTCCAGA	0.667													0	0	0	0.006214	0	9	48										T	7250445	C	T	7250445	2	4	40	1	0	0	0	0	0	0	0	1	118	610	22	2		2	ACAP1	17	7250445	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	32998	7250445	73944765	600	10273										
TP53	7157	broad.mit.edu	37	chr17	7577556	7577556	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccggttcatgccgcccatgCaggaactgttacacatgtag	10	12	1	0	rs121912655		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7577556C>A	uc002gim.2	-	7	919	c.725G>T	c.(724-726)TGC>TTC	p.C242F	TP53_uc002gig.1_Missense_Mutation_p.C242F|TP53_uc002gih.2_Missense_Mutation_p.C242F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C110F|TP53_uc010cng.1_Missense_Mutation_p.C110F|TP53_uc002gii.1_Missense_Mutation_p.C110F|TP53_uc010cnh.1_Missense_Mutation_p.C242F|TP53_uc010cni.1_Missense_Mutation_p.C242F|TP53_uc002gij.2_Missense_Mutation_p.C242F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C149F|TP53_uc002gio.2_Missense_Mutation_p.C110F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	242	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).	Zinc.	C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C242F(63)|p.C242Y(37)|p.C242S(25)|p.C242fs*5(16)|p.C242R(11)|p.C242W(7)|p.0?(7)|p.N239_C242delNSSC(3)|p.C242*(3)|p.C242C(2)|p.C242G(2)|p.C242fs*20(1)|p.C242fs*23(1)|p.Y236_M243delYMCNSSCM(1)|p.C242_M246>L(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.C238fs*21(1)|p.C242fs*98(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241_G245delSCMGG(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGCCCATGCAGGAACTGTT	0.577		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	0.000274275	0.004482	0.000279026	8	39										A	7577556	C	A	7577556	3	1	40	1	0	0	0	0	1	0	0	0	16378	710	25	4	565	4	TP53	17	7577556	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	327111	7577556	73617654	601	10274										
TP53	7157	broad.mit.edu	37	chr17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttccactcggataagatgctGaggaggggccagacctaaga	13	9	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00278	0	23	33										A	7578275	G	A	7578275	4	1	40	1	0	0	0	0	0	1	0	0	16378	1299	45	1	720	1	TP53	17	7578275	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	719	7578275	73616935	602	10275										
EFNB3	1949	broad.mit.edu	37	chr17	7612706	7612706	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagggtctctgggcctggggGgtggaggtgggatgggacct	23	6	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:7612706G>A	uc002gis.2	+	5	1232	c.835G>A	c.(835-837)GGT>AGT	p.G279S		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	ephrin-B3 precursor	279	Cytoplasmic (Potential).				cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			ovary(1)	1		all_cancers(10;1.14e-06)|Prostate(122;0.081)				GGGCCTGGGGGGTGGAGGTGG	0.697													0	0	0	0.00308	0	8	27										A	7612706	G	A	7612706	3	1	40	1	0	0	0	0	1	0	0	0	4957	1232	43	2	853	2	EFNB3	17	7612706	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	34431	7612706	73582504	603	10276										
PIK3R5	23533	broad.mit.edu	37	chr17	8791859	8791859	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgaacttctgcccaggcctGcggtggcctcggcgttcctg	13	14	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:8791859G>A	uc002glt.2	-	10	1312	c.1245C>T	c.(1243-1245)CGC>CGT	p.R415R	PIK3R5_uc010vuz.1_Silent_p.R415R|PIK3R5_uc002glu.3_Silent_p.R29R|PIK3R5_uc010coa.1_3'UTR|PIK3R5_uc010cob.1_Silent_p.R29R	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	415					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GCCCAGGCCTGCGGTGGCCTC	0.632													0	0	0	0.008291	0	10	9										A	8791859	G	A	8791859	2	1	40	1	0	0	0	0	0	0	0	1	11922	1306	46	2		2	PIK3R5	17	8791859	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1179153	8791859	72403351	604	10277										
LRRC48	83450	broad.mit.edu	37	chr17	17891266	17891266	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atctgtctttcaacaacattGagaccatcgaggggctggac	10	10	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:17891266G>A	uc010vxd.1	+	6	677	c.298G>A	c.(298-300)GAG>AAG	p.E100K	LRRC48_uc002gsa.2_Missense_Mutation_p.E100K|LRRC48_uc010vxc.1_Missense_Mutation_p.E100K|LRRC48_uc002gsb.2_Missense_Mutation_p.E100K	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	100	LRR 3.					cytoplasm				pancreas(1)	1	all_neural(463;0.228)					CAACAACATTGAGACCATCGA	0.552													0	0	0	0.006214	0	9	43										A	17891266	G	A	17891266	3	1	40	1	0	0	0	0	1	0	0	0	9005	1291	45	1	308	1	LRRC48	17	17891266	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	9099407	17891266	63303944	605	10278										
B9D1	27077	broad.mit.edu	37	chr17	19251136	19251136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgtgcacggccccatagcctCgaaccacatcgttcccgaac	8	18	0	0	rs148240978		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:19251136C>T	uc002gvk.3	-	4	466	c.302G>A	c.(301-303)CGA>CAA	p.R101Q	B9D1_uc010cqm.1_Missense_Mutation_p.E77K|B9D1_uc002gvl.3_Missense_Mutation_p.E77K|B9D1_uc010vyr.1_Missense_Mutation_p.E121K|B9D1_uc010vys.1_Missense_Mutation_p.E152K|B9D1_uc010cqn.1_Missense_Mutation_p.E152K	NM_015681	NP_056496	Q9UPM9	B9D1_HUMAN	B9 protein	101	B9.				cilium assembly	centrosome|microtubule basal body	protein binding				0	all_cancers(12;2.04e-05)|all_epithelial(12;0.000806)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CCCATAGCCTCGAACCACATC	0.607													0	0	0	0.004482	0	8	35										T	19251136	C	T	19251136	3	4	40	1	0	0	0	0	1	0	0	0	1277	884	31	1	328	1	B9D1	17	19251136	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1359870	19251136	61944074	606	10279										
FOXN1	8456	broad.mit.edu	37	chr17	26856166	26856166	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acctgggctcctcacactatCagtaccagcgaatggcaccc	8	16	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:26856166C>T	uc010crm.2	+	5	952	c.754C>T	c.(754-756)CAG>TAG	p.Q252*	FOXN1_uc002hbj.2_Nonsense_Mutation_p.Q252*	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	252					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CTCACACTATCAGTACCAGCG	0.567													0	0	0	0.00245	0	14	90										T	26856166	C	T	26856166	4	4	40	1	0	0	0	0	0	1	0	0	6019	827	29	1	768	1	FOXN1	17	26856166	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	7605030	26856166	54339044	607	10280										
NEK8	284086	broad.mit.edu	37	chr17	27068520	27068520	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccctcggccagtgcagttgGatgagacacacccttacacg	10	14	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:27068520G>A	uc002hcp.2	+	14	1981	c.1981G>A	c.(1981-1983)GAT>AAT	p.D661N	TRAF4_uc002hcq.1_5'Flank|TRAF4_uc002hcs.2_5'Flank	NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	661	RCC1 5.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					AGTGCAGTTGGATGAGACACA	0.567													0	0	0	0.00245	0	15	64										A	27068520	G	A	27068520	3	1	40	1	0	0	0	0	1	0	0	0	10330	1174	41	1	2035	1	NEK8	17	27068520	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	212354	27068520	54126690	608	10281										
TIAF1	9220	broad.mit.edu	37	chr17	27401192	27401192	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacagagaaaggactgctctCtgaagggtgaagatggagat	14	6	1	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:27401192C>G	uc002hdv.1	-	1	1436	c.26G>C	c.(25-27)AGA>ACA	p.R9T	MYO18A_uc010wbc.1_3'UTR|MYO18A_uc002hds.2_3'UTR|MYO18A_uc010csa.1_3'UTR|MYO18A_uc002hdt.1_3'UTR|MYO18A_uc002hdu.1_3'UTR	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	9					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGACTGCTCTCTGAAGGGTGA	0.597													0	0	0	0.00308	0	7	45										G	27401192	C	G	27401192	3	3	40	1	0	0	0	0	1	0	0	0	15885	913	32	1	325	1	TIAF1	17	27401192	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	332672	27401192	53794018	609	10282										
CORO6	84940	broad.mit.edu	37	chr17	27946710	27946710	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcactggcgataacgttgtCattgtgtggacaccagtcaa	12	9	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:27946710C>T	uc002hel.2	-	2	282	c.280G>A	c.(280-282)GAC>AAC	p.D94N	CORO6_uc002hem.2_5'Flank|CORO6_uc002hen.2_5'Flank	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	94	WD 1.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						ATAACGTTGTCATTGTGTGGA	0.572													0	0	0	0.012319	0	23	141										T	27946710	C	T	27946710	3	4	40	1	0	0	0	0	1	0	0	0	3758	826	29	1	1174	1	CORO6	17	27946710	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	545518	27946710	53248500	610	10283										
TBC1D29	26083	broad.mit.edu	37	chr17	28887196	28887196	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcttctccgggtgctgaatgAtggggtaaggaggcacaggg	18	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:28887196A>G	uc002hfh.2	+	2	223	c.74A>G	c.(73-75)GAT>GGT	p.D25G	TBC1D29_uc002hfi.2_RNA|uc002hfj.1_5'Flank	NM_015594	NP_056409	Q9UFV1	TBC29_HUMAN	TBC1 domain family, member 29	25	Rab-GAP TBC; truncated.					intracellular	Rab GTPase activator activity				0		Myeloproliferative disorder(56;0.0255)				GTGCTGAATGATGGGGTAAGG	0.627													0	0	0	0.000602	0	5	11										G	28887196	A	G	28887196	3	3	40	1	0	0	0	0	1	0	0	0	15615	333	12	5	80	5	TBC1D29	17	28887196	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	940486	28887196	52308014	611	10284										
CCL15	6359	broad.mit.edu	37	chr17	34325917	34325917	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttactgttcagaactactgGattttccagtggaagctttg	9	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:34325917G>A	uc010wcu.1	-	2	690	c.121C>T	c.(121-123)CCA>TCA	p.P41S	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	41					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGAACTACTGGATTTTCCAGT	0.438													0	0	0	0.011902	0	41	70										A	34325917	G	A	34325917	3	1	40	1	0	0	0	0	1	0	0	0	2886	1174	41	1	232	1	CCL15	17	34325917	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5438721	34325917	46869293	612	10285										
ERBB2	2064	broad.mit.edu	37	chr17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctttctacggacgtgggatCctgcaccctcgtctgccccc	9	18	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:37868208C>T	uc002hso.2	+	8	1167	c.929C>T	c.(928-930)TCC>TTC	p.S310F	ERBB2_uc002hsm.2_Missense_Mutation_p.S280F|ERBB2_uc010cwa.2_Missense_Mutation_p.S295F|ERBB2_uc002hsp.2_Missense_Mutation_p.S113F|ERBB2_uc010cwb.2_Missense_Mutation_p.S310F|ERBB2_uc010wek.1_Missense_Mutation_p.S34F|ERBB2_uc002hsl.2_Missense_Mutation_p.S280F|ERBB2_uc002hsn.1_Missense_Mutation_p.S310F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	310	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(2)|p.S310Y(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.01441	0	52	251										T	37868208	C	T	37868208	3	4	40	1	0	0	0	0	1	0	0	0	5206	855	30	1	959	1	ERBB2	17	37868208	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3542291	37868208	43327002	613	10286										
KRT34	3885	broad.mit.edu	37	chr17	39538574	39538574	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggtttgagtctctccttcctCtgcagtccttttataccatt	6	12	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:39538574C>T	uc002hwm.2	-	1	63	c.51G>A	c.(49-51)CAG>CAA	p.Q17Q		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	17	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TCTCCTTCCTCTGCAGTCCTT	0.458													0	0	0	0.010504	0	19	84										T	39538574	C	T	39538574	2	4	40	1	0	0	0	0	0	0	0	1	8471	912	32	1		1	KRT34	17	39538574	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1670366	39538574	41656636	614	10287										
ACLY	47	broad.mit.edu	37	chr17	40070073	40070073	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atggctgaggtggtacagatGaacttgtaaaggagttcttt	13	4	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:40070073G>A	uc002hyg.2	-	2	217	c.54C>T	c.(52-54)TTC>TTT	p.F18F	ACLY_uc002hyh.2_Silent_p.F18F|ACLY_uc002hyi.2_Silent_p.F72F|ACLY_uc010wfx.1_Silent_p.F72F|ACLY_uc010wfy.1_Silent_p.F18F	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	18					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TGGTACAGATGAACTTGTAAA	0.562													0	0	0	0.004656	0	25	178										A	40070073	G	A	40070073	2	1	40	1	0	0	0	0	0	0	0	1	143	1281	45	1		1	ACLY	17	40070073	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	531499	40070073	41125137	615	10288										
GRN	2896	broad.mit.edu	37	chr17	42429721	42429721	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccgccaggctgtgtgctgcGaggatcgccagcactgctgc	14	15	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:42429721G>C	uc002igp.1	+	12	1645	c.1426G>C	c.(1426-1428)GAG>CAG	p.E476Q	GRN_uc002igr.1_Missense_Mutation_p.E270Q	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	476					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGTGTGCTGCGAGGATCGCCA	0.637													0	0	0	0.001168	0	6	28										C	42429721	G	C	42429721	3	2	40	1	0	0	0	0	1	0	0	0	6804	1059	37	1	1468	1	GRN	17	42429721	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2359648	42429721	38765489	616	10289										
PLCD3	113026	broad.mit.edu	37	chr17	43196285	43196285	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccagcagctcaggggcactCagcacgcggtcctcgcccga	12	17	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:43196285C>T	uc002iib.2	-	5	924	c.810G>A	c.(808-810)CTG>CTA	p.L270L		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	270	EF-hand 3.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	CAGGGGCACTCAGCACGCGGT	0.637													0	0	0	0.001984	0	7	11										T	43196285	C	T	43196285	2	4	40	1	0	0	0	0	0	0	0	1	12032	813	29	1		1	PLCD3	17	43196285	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	766564	43196285	37998925	617	10290										
NFE2L1	4779	broad.mit.edu	37	chr17	46128694	46128694	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atggtatccaccccaagagcAtagacctggacaattacttc	7	12	0	2	rs117666459	by1000genomes	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:46128694A>G	uc002imz.3	+	2	865	c.214A>G	c.(214-216)ATA>GTA	p.I72V	NFE2L1_uc002ina.3_Missense_Mutation_p.I72V|NFE2L1_uc002inb.3_Missense_Mutation_p.I72V|NFE2L1_uc002inc.1_Missense_Mutation_p.I72V	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	72					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						CCCCAAGAGCATAGACCTGGA	0.567													0	0	0	0.003755	0	38	115										G	46128694	A	G	46128694	3	3	40	1	0	0	0	0	1	0	0	0	10367	217	8	5	216	5	NFE2L1	17	46128694	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	2932409	46128694	35066516	618	10291										
SAMD14	201191	broad.mit.edu	37	chr17	48191613	48191613	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tttggcctcctgccagggccCactggggatcttggggctgc	15	13	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:48191613C>T	uc002iqg.2	-	8	1179	c.880G>A	c.(880-882)GGG>AGG	p.G294R	SAMD14_uc002iqd.2_Missense_Mutation_p.G77R|SAMD14_uc002iqe.2_Missense_Mutation_p.G77R|SAMD14_uc002iqf.2_Missense_Mutation_p.G322R	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	294											0						TGCCAGGGCCCACTGGGGATC	0.597													0	0	0	0.010729	0	10	36										T	48191613	C	T	48191613	3	4	40	1	0	0	0	0	1	0	0	0	13819	594	21	2	385	2	SAMD14	17	48191613	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2062919	48191613	33003597	619	10292										
XYLT2	64132	broad.mit.edu	37	chr17	48434547	48434547	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gagacgcttgagatgtggctGatgccccaagggtcgctgaa	15	9	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:48434547G>A	uc002iqo.2	+	9	1984	c.1875G>A	c.(1873-1875)CTG>CTA	p.L625L	XYLT2_uc010dbo.2_Intron	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	625	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AGATGTGGCTGATGCCCCAAG	0.632													0	0	0	0.001168	0	6	15										A	48434547	G	A	48434547	2	1	40	1	0	0	0	0	0	0	0	1	17461	1277	45	1		1	XYLT2	17	48434547	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	242934	48434547	32760663	620	10293										
LRRC59	55379	broad.mit.edu	37	chr17	48460409	48460409	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcatggcggcgtagaccctgGaccgcattgtcatagatggt	13	10	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:48460409G>A	uc002iqt.2	-	7	1018	c.864C>T	c.(862-864)GTC>GTT	p.V288V		NM_018509	NP_060979	Q96AG4	LRC59_HUMAN	leucine rich repeat containing 59	288	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial nucleoid	protein binding			central_nervous_system(1)	1	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			GTAGACCCTGGACCGCATTGT	0.597													0	0	0	0.001168	0	6	8										A	48460409	G	A	48460409	2	1	40	1	0	0	0	0	0	0	0	1	9015	1161	41	1		1	LRRC59	17	48460409	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	25862	48460409	32734801	621	10294										
RAD51C	5889	broad.mit.edu	37	chr17	56809868	56809868	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcaacattgtacaagtcacCcagccagaaggaatgcacag	10	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:56809868C>A	uc002iwu.2	+	8	1031	c.989C>A	c.(988-990)CCC>CAC	p.P330H	RAD51C_uc010woa.1_Missense_Mutation_p.P330H|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	330					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TACAAGTCACCCAGCCAGAAG	0.328								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				1	0	7.26314e-15	0.007291	7.58155e-15	24	83										A	56809868	C	A	56809868	3	1	40	1	0	0	0	0	1	0	0	0	12988	623	22	4	1023	4	RAD51C	17	56809868	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	8349459	56809868	24385342	622	10295										
HELZ	9931	broad.mit.edu	37	chr17	65141898	65141898	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctgtgctatttttttcttgTacatcttctcctcgtgctgt	7	10	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:65141898T>C	uc010wqk.1	-	21	2920	c.2733A>G	c.(2731-2733)GTA>GTG	p.V911V	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.V910V	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TTTTTTCTTGTACATCTTCTC	0.373													0	0	0	0.008291	0	11	108										C	65141898	T	C	65141898	2	2	40	1	0	0	0	0	0	0	0	1	7049	1625	57	5		5	HELZ	17	65141898	Silent	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	8332030	65141898	16053312	623	10296										
ABCA6	23460	broad.mit.edu	37	chr17	67075194	67075194	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaaatttcctacttcctgttCtttagaaagctctaagaata	4	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:67075194C>G	uc002jhw.1	-	39	4949	c.4774G>C	c.(4774-4776)GAA>CAA	p.E1592Q		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1592					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ACTTCCTGTTCTTTAGAAAGC	0.348													0	0	0	0.010729	0	12	54										G	67075194	C	G	67075194	3	3	40	1	0	0	0	0	1	0	0	0	36	922	32	1	83	1	ABCA6	17	67075194	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1933296	67075194	14120016	624	10297										
DNAI2	64446	broad.mit.edu	37	chr17	72301563	72301563	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtctgaagacagccgggaatCgtccatcatgtggaccaagt	12	10	2	2	rs143470009		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:72301563C>T	uc002jkf.2	+	9	1292	c.1193C>T	c.(1192-1194)TCG>TTG	p.S398L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_3'UTR|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	398	WD 4.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						AGCCGGGAATCGTCCATCATG	0.622									Kartagener_syndrome				0	0	0	0.008291	0	11	17										T	72301563	C	T	72301563	3	4	40	1	0	0	0	0	1	0	0	0	4610	893	31	1	1223	1	DNAI2	17	72301563	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	5226369	72301563	8893647	625	10298										
GRIN2C	2905	broad.mit.edu	37	chr17	72842905	72842905	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggctggggacccaccccatcTtgaggctggtgagcgcgtcc	15	14	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:72842905T>C	uc002jlt.1	-	10	2312	c.2156A>G	c.(2155-2157)AAG>AGG	p.K719R	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.K719R	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	719	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CCACCCCATCTTGAGGCTGGT	0.617													0	0	0	0.00278	0	12	26										C	72842905	T	C	72842905	3	2	40	1	0	0	0	0	1	0	0	0	6781	1609	56	5	1561	5	GRIN2C	17	72842905	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	541342	72842905	8352305	626	10299										
OTOP2	92736	broad.mit.edu	37	chr17	72929508	72929508	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcggggcccgccctcatttCagcaacacagtggaggtgga	13	12	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:72929508C>T	uc010wrp.1	+	8	1646	c.1557C>T	c.(1555-1557)TTC>TTT	p.F519F	OTOP3_uc010wrq.1_5'Flank|OTOP3_uc010wrr.1_5'Flank	NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	519						integral to membrane				ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					GCCCTCATTTCAGCAACACAG	0.572													0	0	0	0.00333	0	20	77										T	72929508	C	T	72929508	2	4	40	1	0	0	0	0	0	0	0	1	11306	825	29	1		1	OTOP2	17	72929508	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	86603	72929508	8265702	627	10300										
ICT1	3396	broad.mit.edu	37	chr17	73017052	73017052	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgggaaaggctgagacaaaaGagaattcattctgctgtaaa	11	6	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:73017052G>A	uc002jmm.2	+	6	575	c.573G>A	c.(571-573)AAG>AAA	p.K191K		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	191					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					TGAGACAAAAGAGAATTCATT	0.498													0	0	0	0.008361	0	30	64										A	73017052	G	A	73017052	2	1	40	1	0	0	0	0	0	0	0	1	7488	933	33	1		1	ICT1	17	73017052	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	87544	73017052	8178158	628	10301										
UNC13D	201294	broad.mit.edu	37	chr17	73839336	73839336	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtgtagagtgcgtcctcgtaGagcagggcccgctaagacac	14	11	0	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:73839336G>C	uc002jpp.2	-	3	545	c.165C>G	c.(163-165)CTC>CTG	p.L55L	UNC13D_uc010wsk.1_Silent_p.L55L|UNC13D_uc002jpq.1_5'UTR|UNC13D_uc010dgq.1_5'Flank	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	55					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGTCCTCGTAGAGCAGGGCCC	0.642									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.001168	0	5	22										C	73839336	G	C	73839336	2	2	40	1	0	0	0	0	0	0	0	1	16984	929	33	1		1	UNC13D	17	73839336	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	822284	73839336	7355874	629	10302										
UBE2O	63893	broad.mit.edu	37	chr17	74387282	74387282	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccctgctagctgaggccagGccctgggcaccgccctctga	12	17	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr17:74387282G>A	uc002jrm.3	-	18	3686	c.3621C>T	c.(3619-3621)GGC>GGT	p.G1207G	UBE2O_uc002jrl.3_Silent_p.G811G	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1207							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CTGAGGCCAGGCCCTGGGCAC	0.632													0	0	0	0.00245	0	13	96										A	74387282	G	A	74387282	2	1	40	1	0	0	0	0	0	0	0	1	16865	1190	42	2		2	UBE2O	17	74387282	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	547946	74387282	6807928	630	10303										
EPB41L3	23136	broad.mit.edu	37	chr18	5397338	5397338	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcctccaccaacacggtctCctgcaccaccttctcagtgc	5	20	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:5397338C>T	uc002kmt.1	-	18	2646	c.2560G>A	c.(2560-2562)GAG>AAG	p.E854K	EPB41L3_uc010wzh.1_Missense_Mutation_p.E685K|EPB41L3_uc002kmu.1_Missense_Mutation_p.E632K|EPB41L3_uc010dkq.1_Missense_Mutation_p.E523K|EPB41L3_uc002kms.1_Missense_Mutation_p.E89K|EPB41L3_uc010wze.1_Missense_Mutation_p.E159K|EPB41L3_uc010wzf.1_Missense_Mutation_p.E151K|EPB41L3_uc010wzg.1_Missense_Mutation_p.E126K|EPB41L3_uc010dkr.2_Missense_Mutation_p.E246K	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	854	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AACACGGTCTCCTGCACCACC	0.602													0	0	0	0.00308	0	8	40										T	5397338	C	T	5397338	3	4	40	1	0	0	0	0	1	0	0	0	5154	864	30	1	723	1	EPB41L3	18	5397338	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		5397338	72679910	631	10304										
KATNAL2	83473	broad.mit.edu	37	chr18	44626625	44626625	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggttttttggctgtttcagGagactgagggctactcaggc	14	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:44626625G>A	uc002lco.2	+	14	1353	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	KATNAL2_uc002lcp.3_Missense_Mutation_p.E314K	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	459						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						GCTGTTTCAGGAGACTGAGGG	0.507											OREG0024959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	23	35										A	44626625	G	A	44626625	3	1	40	1	0	0	0	0	1	0	0	0	7986	1188	41	1	1209	1	KATNAL2	18	44626625	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	39229287	44626625	33450623	632	10305										
MYO5B	4645	broad.mit.edu	37	chr18	47428979	47428980	+	Missense_Mutation	DNP	CC	CC	AA													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctgacctgctcatcgatcttCcgctgcagctggaccacctt							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:47428979_47428980CC>AA	uc002leb.2	-	21	3083_3084	c.2795_2796GG>TT	c.(2794-2796)CGG>CTT	p.R932L	MYO5B_uc002lea.2_Missense_Mutation_p.R73L	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	932	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CATCGATCTTCCGCTGCAGCTG	0.594													0	0	0	0.004672	0	27	53										AA	47428980	CC	AA	47428979	3	1	40	1	0	0	0	0	1	0	0	0	10079	842	30	3	2830	3	MYO5B	18	47428979	Missense_Mutation	DNP	CC	TCGA-DK-A1A3-01A-11D-A13W-08	2802354	47428979	30648269	633	10306										
DCC	1630	broad.mit.edu	37	chr18	50977029	50977029	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acgctcttcagcccagcagaGaaagtaggtaacagctggtt	11	10	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:50977029G>C	uc002lfe.1	+	23	3976	c.3389G>C	c.(3388-3390)AGA>ACA	p.R1130T	DCC_uc010dpf.1_Missense_Mutation_p.R765T	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1130	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCCCAGCAGAGAAAGTAGGTA	0.473													0	0	0	0.001168	0	5	32										C	50977029	G	C	50977029	3	2	40	1	0	0	0	0	1	0	0	0	4282	942	33	1	3479	1	DCC	18	50977029	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3548050	50977029	27100219	634	10307										
MBD2	8932	broad.mit.edu	37	chr18	51731413	51731413	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgcagtctctgtttgttcttCtgtaatttactaggcatcat	7	9	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:51731413C>T	uc002lfg.1	-	2	886	c.657G>A	c.(655-657)CAG>CAA	p.Q219Q	MBD2_uc002lfh.1_Silent_p.Q219Q	NM_003927	NP_003918	Q9UBB5	MBD2_HUMAN	methyl-CpG binding domain protein 2 isoform 1	219					transcription, DNA-dependent		C2H2 zinc finger domain binding|methyl-CpG binding|satellite DNA binding				0				Colorectal(16;0.0212)|READ - Rectum adenocarcinoma(32;0.188)	Hexobarbital(DB01355)	GTTTGTTCTTCTGTAATTTAC	0.388													0	0	0	0.01441	0	74	148										T	51731413	C	T	51731413	2	4	40	1	0	0	0	0	0	0	0	1	9343	912	32	1		1	MBD2	18	51731413	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	754384	51731413	26345835	635	10308										
CD226	10666	broad.mit.edu	37	chr18	67562996	67562996	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcctgcgctggcctgcaagTagcagcggtaaagccccgag	13	14	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:67562996T>C	uc010dqo.2	-	3	1115	c.668A>G	c.(667-669)TAC>TGC	p.Y223C	CD226_uc002lkm.3_Missense_Mutation_p.Y223C	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	223	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				GGCCTGCAAGTAGCAGCGGTA	0.522													0	0	0	0.00333	0	24	141										C	67562996	T	C	67562996	3	2	40	1	0	0	0	0	1	0	0	0	2986	1638	57	5	358	5	CD226	18	67562996	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	15831583	67562996	10514252	636	10309										
RTTN	25914	broad.mit.edu	37	chr18	67871418	67871418	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccatcaatttcagcctgcaGatttggctccacattagacc	7	13	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:67871418G>C	uc002lkp.2	-	3	369	c.301C>G	c.(301-303)CTG>GTG	p.L101V	RTTN_uc010xfb.1_Translation_Start_Site|RTTN_uc002lkq.1_Missense_Mutation_p.L101V	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	101							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TCAGCCTGCAGATTTGGCTCC	0.433													0	0	0	0.007413	0	19	134										C	67871418	G	C	67871418	3	2	40	1	0	0	0	0	1	0	0	0	13737	933	33	1	6567	1	RTTN	18	67871418	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	308422	67871418	10205830	637	10310										
CTDP1	9150	broad.mit.edu	37	chr18	77474710	77474710	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccaggcccccaccagcagccAagagctggcaggcgctcctg	12	18	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr18:77474710A>C	uc002lnh.1	+	8	1397	c.1250A>C	c.(1249-1251)CAA>CCA	p.Q417P	CTDP1_uc002lni.1_Missense_Mutation_p.Q417P|CTDP1_uc010drd.1_Missense_Mutation_p.Q417P	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	417					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		ACCAGCAGCCAAGAGCTGGCA	0.746													0	0	0	0.001984	0	7	4										C	77474710	A	C	77474710	3	2	40	1	0	0	0	0	1	0	0	0	4002	130	5	5	1280	5	CTDP1	18	77474710	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	9603292	77474710	602538	638	10311										
ZNF555	148254	broad.mit.edu	37	chr19	2853251	2853251	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	catggtggagagaaaccctaTgaatgcaaccagtgcgggaa	13	8	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:2853251T>A	uc002lwo.2	+	4	1277	c.1188T>A	c.(1186-1188)TAT>TAA	p.Y396*	ZNF555_uc002lwn.3_Nonsense_Mutation_p.Y395*	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	396	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAAACCCTATGAATGCAACC	0.498													0	0	0	0.006214	0	10	64										A	2853251	T	A	2853251	4	1	40	1	0	0	0	0	0	1	0	0	17983	1471	51	5	1202	5	ZNF555	19	2853251	Nonsense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08		2853251	56275732	639	10312										
TLE6	79816	broad.mit.edu	37	chr19	2987903	2987903	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtctccccactagcccccagGccacctgaggcctcctccag	8	21	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:2987903G>A	uc002lwu.2	+	9	664	c.264G>A	c.(262-264)AGG>AGA	p.R88R	TLE6_uc002lwt.2_Silent_p.R211R|TLE6_uc010dtg.2_Silent_p.R211R|TLE6_uc002lwv.2_5'UTR	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	88					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCCCCCAGGCCACCTGAGG	0.667													0	0	0	0.00245	0	13	18										A	2987903	G	A	2987903	2	1	40	1	0	0	0	0	0	0	0	1	15939	1194	42	2		2	TLE6	19	2987903	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	134652	2987903	56141080	640	10313										
GNA15	2769	broad.mit.edu	37	chr19	3157790	3157790	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	actaccctggttcaaaagcaCatccgtcatcctctttctca	4	15	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:3157790C>T	uc002lxf.2	+	6	1067	c.809C>T	c.(808-810)ACA>ATA	p.T270I		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	270					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		TTCAAAAGCACATCCGTCATC	0.507													0	0	0	0.004289	0	36	213										T	3157790	C	T	3157790	3	4	40	1	0	0	0	0	1	0	0	0	6503	478	17	2	831	2	GNA15	19	3157790	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	169887	3157790	55971193	641	10314										
C19orf28	126321	broad.mit.edu	37	chr19	3551099	3551099	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agatcacgatgaacgggccgTagtagaggagggcagcccac	15	10	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:3551099T>C	uc002lxz.2	-	2	562	c.392A>G	c.(391-393)TAC>TGC	p.Y131C	C19orf28_uc002lxw.2_Missense_Mutation_p.Y131C|C19orf28_uc002lxx.2_Missense_Mutation_p.Y131C|C19orf28_uc002lxy.2_Missense_Mutation_p.Y122C	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	131	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		GAACGGGCCGTAGTAGAGGAG	0.637													0	0	0	0.001168	0	5	22										C	3551099	T	C	3551099	3	2	40	1	0	0	0	0	1	0	0	0	1917	1638	57	5	1293	5	C19orf28	19	3551099	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	393309	3551099	55577884	642	10315										
EEF2	1938	broad.mit.edu	37	chr19	3984133	3984133	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagagggcacagggagctcaCgttgacttgatggtgatgca	15	8	1	4	rs113603517		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:3984133C>G	uc002lze.2	-	2	301	c.218_splice	c.e2+1	p.T73_splice	SNORD37_uc002lzf.1_5'Flank	NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2							cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGGAGCTCACGTTGACTTGA	0.657													0	0	0	0.006122	0	17	39										G	3984133	C	G	3984133	5	3	40	1	0	0	0	0	0	0	1	0	4929	550	19	4	2413	4	EEF2	19	3984133	Splice_Site	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	433034	3984133	55144850	643	10316										
ACSBG2	81616	broad.mit.edu	37	chr19	6177390	6177390	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggcgctcacatactttgctCaagcagatgctctcaaggta	10	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:6177390C>T	uc002mef.1	+	8	1116	c.889C>T	c.(889-891)CAA>TAA	p.Q297*	ACSBG2_uc002mee.1_Nonsense_Mutation_p.Q110*|ACSBG2_uc002meg.1_Nonsense_Mutation_p.Q297*|ACSBG2_uc002meh.1_Nonsense_Mutation_p.Q297*|ACSBG2_uc002mei.1_Nonsense_Mutation_p.Q247*|ACSBG2_uc010xiz.1_Nonsense_Mutation_p.Q297*	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	297					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						ATACTTTGCTCAAGCAGATGC	0.507													0	0	0	0.007413	0	20	34										T	6177390	C	T	6177390	4	4	40	1	0	0	0	0	0	1	0	0	174	827	29	1	915	1	ACSBG2	19	6177390	Nonsense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2193257	6177390	52951593	644	10317										
ZNF557	79230	broad.mit.edu	37	chr19	7083113	7083113	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aatgactgtgggaaaaccttCagcagcagatcttaccttac	8	10	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:7083113C>T	uc002mgb.2	+	8	1115	c.630C>T	c.(628-630)TTC>TTT	p.F210F	ZNF557_uc002mga.2_Silent_p.F217F|ZNF557_uc002mgc.2_Silent_p.F217F	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	210	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		GGAAAACCTTCAGCAGCAGAT	0.438													0	0	0	0.008361	0	32	52										T	7083113	C	T	7083113	2	4	40	1	0	0	0	0	0	0	0	1	17985	825	29	1		1	ZNF557	19	7083113	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	905723	7083113	52045870	645	10318										
XAB2	56949	broad.mit.edu	37	chr19	7684884	7684884	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gggctggtcacgctccgcctCagccgccagctgctctgccc	12	19	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:7684884C>T	uc002mgx.2	-	17	2370	c.2344G>A	c.(2344-2346)GAG>AAG	p.E782K		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	782					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CGCTCCGCCTCAGCCGCCAGC	0.667								Direct_reversal_of_damage|NER					0	0	0	0.000602	0	4	16										T	7684884	C	T	7684884	3	4	40	1	0	0	0	0	1	0	0	0	17415	835	29	1	235	1	XAB2	19	7684884	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	601771	7684884	51444099	646	10319										
FBN3	84467	broad.mit.edu	37	chr19	8136970	8136970	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	actgcgtcgtggccggtcccGaggggagaggccattgatct	16	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:8136970G>T	uc002mjf.2	-	62	8071	c.8050C>A	c.(8050-8052)CGG>AGG	p.R2684R	FBN3_uc002mje.2_Silent_p.R480R	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2684						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGCCGGTCCCGAGGGGAGAGG	0.647													1	0	2.2871e-25	0.007835	2.41309e-25	37	142										T	8136970	G	T	8136970	2	4	40	1	0	0	0	0	0	0	0	1	5704	1057	37	3		3	FBN3	19	8136970	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	452086	8136970	50992013	647	10320										
MUC16	94025	broad.mit.edu	37	chr19	9071731	9071731	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aggtggcactgtggacttatCatggtctggggtggaaattt	15	5	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:9071731C>T	uc002mkp.2	-	3	15919	c.15715G>A	c.(15715-15717)GAT>AAT	p.D5239N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5241	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGACTTATCATGGTCTGGG	0.478													0	0	0	0.009535	0	29	156										T	9071731	C	T	9071731	3	4	40	1	0	0	0	0	1	0	0	0	9973	826	29	1	28136	1	MUC16	19	9071731	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	934761	9071731	50057252	648	10321										
MUC16	94025	broad.mit.edu	37	chr19	9077704	9077704	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acttcctagggctgtggactGaagggtgactggttccactg	14	9	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:9077704G>A	uc002mkp.2	-	3	9946	c.9742C>T	c.(9742-9744)CAG>TAG	p.Q3248*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3249	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGTGGACTGAAGGGTGACT	0.517													0	0	0	0.00333	0	23	166										A	9077704	G	A	9077704	4	1	40	1	0	0	0	0	0	1	0	0	9973	1299	45	1	34109	1	MUC16	19	9077704	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5973	9077704	50051279	649	10322										
KEAP1	9817	broad.mit.edu	37	chr19	10599968	10599969	+	Frame_Shift_Ins	INS	-	-	CA													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctctgtttccacatcgtagINScgctccacgctgttcagctg							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:10599968_10599969insCA	uc002moq.1	-	5	1763_1764	c.1607_1608insTG	c.(1606-1608)CGCfs	p.R536fs	KEAP1_uc002mop.1_Intron|KEAP1_uc002mor.1_Frame_Shift_Ins_p.R536fs	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	536	Kelch 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCACATCGTAGCGCTCCACGCT	0.574																		11	27	---	---								CA	10599969	-	CA	10599968	7	5	40	1	0	1	1	0	0	0	0	0	8141	958	34	0	274	0	KEAP1	19	10599968	Frame_Shift_Ins	INS	-	TCGA-DK-A1A3-01A-11D-A13W-08	1522264	10599968	48529015	650	10323										
KEAP1	9817	broad.mit.edu	37	chr19	10610637	10610637	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caccgcgtcccctgccccctCagggcactgtgactgcaggg	12	18	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:10610637C>T	uc002moq.1	-	2	229	c.73G>A	c.(73-75)GAG>AAG	p.E25K	KEAP1_uc002mor.1_Missense_Mutation_p.E25K	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCTGCCCCCTCAGGGCACTGT	0.652													0	0	0	0.007413	0	19	73										T	10610637	C	T	10610637	3	4	40	1	0	0	0	0	1	0	0	0	8141	835	29	1	1821	1	KEAP1	19	10610637	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	10669	10610637	48518346	651	10324										
ZNF700	90592	broad.mit.edu	37	chr19	12060204	12060204	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaggaatgtgggaaagccttCagatctacctcacaccttcg	9	11	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:12060204C>T	uc002msu.2	+	4	1491	c.1365C>T	c.(1363-1365)TTC>TTT	p.F455F	ZNF700_uc010xme.1_Silent_p.F473F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	455	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAAAGCCTTCAGATCTACCT	0.488													0	0	0	0.012319	0	23	94										T	12060204	C	T	12060204	2	4	40	1	0	0	0	0	0	0	0	1	18101	825	29	1		1	ZNF700	19	12060204	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1449567	12060204	47068779	652	10325										
BRD4	23476	broad.mit.edu	37	chr19	15367816	15367816	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgctgggctcgctcctcctCagagtcatcagtcgaactgt	10	15	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:15367816C>T	uc002nar.2	-	8	1732	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K	BRD4_uc002nas.2_Missense_Mutation_p.E504K|BRD4_uc002nat.3_Missense_Mutation_p.E504K|BRD4_uc002nau.3_Missense_Mutation_p.E504K	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	504					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			CGCTCCTCCTCAGAGTCATCA	0.647			T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.009096	0	3	3										T	15367816	C	T	15367816	3	4	40	1	0	0	0	0	1	0	0	0	1504	835	29	1	2645	1	BRD4	19	15367816	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3307612	15367816	43761167	653	10326										
CHERP	10523	broad.mit.edu	37	chr19	16633881	16633881	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accttcacgaggggggccatCagcccagcagggagatcgaa	14	12	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:16633881C>T	uc002nei.1	-	11	2036	c.1962G>A	c.(1960-1962)CTG>CTA	p.L654L	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Silent_p.L193L	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	654	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GGGGGGCCATCAGCCCAGCAG	0.617													0	0	0	0.013537	0	13	64										T	16633881	C	T	16633881	2	4	40	1	0	0	0	0	0	0	0	1	3336	813	29	1		1	CHERP	19	16633881	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1266065	16633881	42495102	654	10327										
CHERP	10523	broad.mit.edu	37	chr19	16634026	16634026	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cgaagtcagggtgctggggtCcagcccaaggcgggtgctcg	18	11	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:16634026C>G	uc002nei.1	-	11	1891	c.1817G>C	c.(1816-1818)GGA>GCA	p.G606A	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Missense_Mutation_p.G145A	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	606	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GTGCTGGGGTCCAGCCCAAGG	0.662													0	0	0	0.004007	0	14	82										G	16634026	C	G	16634026	3	3	40	1	0	0	0	0	1	0	0	0	3336	855	30	1	961	1	CHERP	19	16634026	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	145	16634026	42494957	655	10328										
CHERP	10523	broad.mit.edu	37	chr19	16640540	16640540	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggaggcgtggccttgacttCagcctccatctgcggcatct	12	13	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:16640540C>T	uc002nei.1	-	8	1122	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	MED26_uc002nee.2_Intron	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	350					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GCCTTGACTTCAGCCTCCATC	0.562													0	0	0	0.00308	0	6	4										T	16640540	C	T	16640540	3	4	40	1	0	0	0	0	1	0	0	0	3336	835	29	1	1742	1	CHERP	19	16640540	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	6514	16640540	42488443	656	10329										
MYO9B	4650	broad.mit.edu	37	chr19	17213295	17213295	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacttcctcatccactgcctCaccgccctcagccagaaggg	7	18	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:17213295C>G	uc010eak.2	+	2	920	c.768C>G	c.(766-768)CTC>CTG	p.L256L	MYO9B_uc002nfi.2_Silent_p.L256L|MYO9B_uc002nfj.1_Silent_p.L256L	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	256	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						TCCACTGCCTCACCGCCCTCA	0.642													0	0	0	0.004482	0	8	20										G	17213295	C	G	17213295	2	3	40	1	0	0	0	0	0	0	0	1	10085	813	29	1		1	MYO9B	19	17213295	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	572755	17213295	41915688	657	10330										
ABHD8	79575	broad.mit.edu	37	chr19	17405304	17405304	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccttggctccttggcgggcGaagccggccctggtggtggt	17	12	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:17405304G>A	uc002ngb.3	-	4	1182	c.942C>T	c.(940-942)TTC>TTT	p.F314F		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	314							hydrolase activity				0						CTTGGCGGGCGAAGCCGGCCC	0.647													0	0	0	0.001855	0	12	94										A	17405304	G	A	17405304	2	1	40	1	0	0	0	0	0	0	0	1	87	1049	37	1		1	ABHD8	19	17405304	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	192009	17405304	41723679	658	10331										
ANO8	57719	broad.mit.edu	37	chr19	17440786	17440786	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	accaggacaactttgatgatGaggtgcttctcataggcgct	11	9	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:17440786G>A	uc002ngf.2	-	11	1470	c.1311C>T	c.(1309-1311)CTC>CTT	p.L437L	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	437	Extracellular (Potential).|Leu-rich.					chloride channel complex	chloride channel activity			ovary(3)	3						CTTTGATGATGAGGTGCTTCT	0.622													0	0	0	0.003163	0	15	88										A	17440786	G	A	17440786	2	1	40	1	0	0	0	0	0	0	0	1	703	1277	45	1		1	ANO8	19	17440786	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	35482	17440786	41688197	659	10332										
PDE4C	5143	broad.mit.edu	37	chr19	18321950	18321950	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctcggggttggtgaggtctGagggacttcgggggatcttg	20	6	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:18321950G>C	uc010xqc.1	-	15	2408	c.1928C>G	c.(1927-1929)TCA>TGA	p.S643*	PDE4C_uc002nik.3_Nonsense_Mutation_p.S643*|PDE4C_uc002nil.3_Nonsense_Mutation_p.S643*|PDE4C_uc002nif.3_Nonsense_Mutation_p.S412*|PDE4C_uc002nig.3_Nonsense_Mutation_p.S358*|PDE4C_uc002nih.3_Nonsense_Mutation_p.S413*|PDE4C_uc010ebk.2_Nonsense_Mutation_p.S537*|PDE4C_uc002nii.3_Nonsense_Mutation_p.S611*|PDE4C_uc010ebl.2_Nonsense_Mutation_p.S357*	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	643					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GGTGAGGTCTGAGGGACTTCG	0.468													0	0	0	0.001855	0	12	127										C	18321950	G	C	18321950	4	2	40	1	0	0	0	0	0	1	0	0	11641	1294	45	1	214	1	PDE4C	19	18321950	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	881164	18321950	40807033	660	10333										
UPF1	5976	broad.mit.edu	37	chr19	18963840	18963840	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgggacctgggccttaacaaGaagagaatcgcctacttcac	10	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:18963840G>A	uc002nkg.2	+	7	1292	c.1017G>A	c.(1015-1017)AAG>AAA	p.K339K	UPF1_uc002nkf.2_Silent_p.K339K	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	339	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCCTTAACAAGAAGAGAATCG	0.453													0	0	0	0.01441	0	54	101										A	18963840	G	A	18963840	2	1	40	1	0	0	0	0	0	0	0	1	17000	933	33	1		1	UPF1	19	18963840	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	641890	18963840	40165143	661	10334										
SFRS14	10147	broad.mit.edu	37	chr19	19135806	19135806	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttcatcttgacacttagctCgtaggcattgcaggccataa	8	11	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:19135806C>G	uc002nkx.2	-	3	1497	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	SFRS14_uc002nkz.1_Missense_Mutation_p.E465Q|SFRS14_uc002nla.1_Missense_Mutation_p.E451Q|SFRS14_uc002nlb.2_Missense_Mutation_p.E451Q|SFRS14_uc010xqk.1_Missense_Mutation_p.E220Q	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	451					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			ACACTTAGCTCGTAGGCATTG	0.473													0	0	0	0.007835	0	42	253										G	19135806	C	G	19135806	3	3	40	1	0	0	0	0	1	0	0	0	14170	893	31	1	1929	1	SFRS14	19	19135806	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	171966	19135806	39993177	662	10335										
SF4	57794	broad.mit.edu	37	chr19	19431303	19431303	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cggttgtccatcttgagactCatccaatcccacaatgctcc	6	15	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:19431303C>T	uc002nmh.2	-	1	5	c.3G>A	c.(1-3)ATG>ATA	p.M1I	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA|KIAA0892_uc002nmk.3_5'Flank	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	1					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						TCTTGAGACTCATCCAATCCC	0.612													0	0	0	0.005443	0	29	84										T	19431303	C	T	19431303	3	4	40	1	0	0	0	0	1	0	0	0	14155	826	29	1	1990	1	SF4	19	19431303	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	295497	19431303	39697680	663	10336										
GATAD2A	54815	broad.mit.edu	37	chr19	19612021	19612021	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgccgctggcgggaggagaaGagcggcgccatcatgtgtga	18	9	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:19612021G>A	uc010xqt.1	+	9	1608	c.1296G>A	c.(1294-1296)AAG>AAA	p.K432K	GATAD2A_uc010xqu.1_Silent_p.K61K|GATAD2A_uc010xqv.1_Silent_p.K452K|GATAD2A_uc010xqw.1_Silent_p.K260K	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	432	GATA-type.				DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGGAGGAGAAGAGCGGCGCCA	0.622													0	0	0	0.00308	0	7	44										A	19612021	G	A	19612021	2	1	40	1	0	0	0	0	0	0	0	1	6260	933	33	1		1	GATAD2A	19	19612021	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	180718	19612021	39516962	664	10337										
ZNF737	100129842	broad.mit.edu	37	chr19	20728335	20728335	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacatttgtaccgtttctctCcagtatgaattctcttatgt	5	10	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:20728335C>G	uc002npa.2	-	4	854	c.674G>C	c.(673-675)GGA>GCA	p.G225A		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	225					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CCGTTTCTCTCCAGTATGAAT	0.403													0	0	0	0.004672	0	3	56										G	20728335	C	G	20728335	3	3	40	1	0	0	0	0	1	0	0	0	18123	855	30	1	940	1	ZNF737	19	20728335	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1116314	20728335	38400648	665	10338										
KIAA0355	9710	broad.mit.edu	37	chr19	34818939	34818939	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagcagacggggcggaggcaGacacccccgcagcccatgca	14	16	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:34818939G>A	uc002nvd.3	+	6	1846	c.987G>A	c.(985-987)CAG>CAA	p.Q329Q		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	329										ovary(1)	1	Esophageal squamous(110;0.162)					GGCGGAGGCAGACACCCCCGC	0.617													0	0	0	0.009718	0	42	107										A	34818939	G	A	34818939	2	1	40	1	0	0	0	0	0	0	0	1	8170	933	33	1		1	KIAA0355	19	34818939	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	14090604	34818939	24310044	666	10339										
LSR	51599	broad.mit.edu	37	chr19	35758034	35758034	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgagtgaagtcacctccctCcacgaggacgactggcgatc	11	13	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:35758034C>G	uc002nyl.2	+	9	1534	c.1311C>G	c.(1309-1311)CTC>CTG	p.L437L	LSR_uc002nym.2_Silent_p.L418L|LSR_uc002nyn.2_Silent_p.L369L|LSR_uc002nyo.2_Silent_p.L417L|LSR_uc010xsr.1_Silent_p.L329L|LSR_uc002nyp.2_Silent_p.L379L|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	437	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TCACCTCCCTCCACGAGGACG	0.682													0	0	0	0.001984	0	6	33										G	35758034	C	G	35758034	2	3	40	1	0	0	0	0	0	0	0	1	9064	842	30	1		1	LSR	19	35758034	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	939095	35758034	23370949	667	10340										
WDR62	284403	broad.mit.edu	37	chr19	36591653	36591653	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgctgtcttccccatagtcaGagagtccccaggaagctggc	11	13	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:36591653G>A	uc002odc.2	+	23	2834	c.2743G>A	c.(2743-2745)GAG>AAG	p.E915K	WDR62_uc002odd.2_Missense_Mutation_p.E915K	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	915					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCCATAGTCAGAGAGTCCCCA	0.627													0	0	0	0.010504	0	17	103										A	36591653	G	A	36591653	3	1	40	1	0	0	0	0	1	0	0	0	17310	943	33	1	2833	1	WDR62	19	36591653	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	833619	36591653	22537330	668	10341										
ZFP82	284406	broad.mit.edu	37	chr19	36884578	36884578	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	acattcatagagtttttcacCagaatgaagtctctgatgtc	7	8	3	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:36884578C>T	uc002ody.1	-	5	899	c.664G>A	c.(664-666)GGT>AGT	p.G222S		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						AGTTTTTCACCAGAATGAAGT	0.413													0	0	0	0.007291	0	29	118										T	36884578	C	T	36884578	3	4	40	1	0	0	0	0	1	0	0	0	17650	594	21	2	938	2	ZFP82	19	36884578	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	292925	36884578	22244405	669	10342										
ZNF829	374899	broad.mit.edu	37	chr19	37382767	37382767	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctgatgctgaataagccttGagtgttgagtaaaggctttc	11	6	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:37382767G>C	uc002ofa.1	-	6	1288	c.926C>G	c.(925-927)TCA>TGA	p.S309*	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	309	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATAAGCCTTGAGTGTTGAGT	0.383													0	0	0	0.00499	0	18	216										C	37382767	G	C	37382767	4	2	40	1	0	0	0	0	0	1	0	0	18179	1294	45	1	376	1	ZNF829	19	37382767	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	498189	37382767	21746216	670	10343										
ZNF527	84503	broad.mit.edu	37	chr19	37880276	37880276	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcacacaggagagaaaccctTcaaatgtagtgaatgtggga	11	7	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:37880276T>A	uc010efk.1	+	5	1436	c.1325T>A	c.(1324-1326)TTC>TAC	p.F442Y	ZNF527_uc002ogf.3_Missense_Mutation_p.F410Y|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	442	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGAAACCCTTCAAATGTAGT	0.428													0	0	0	0.001984	0	7	249										A	37880276	T	A	37880276	3	1	40	1	0	0	0	0	1	0	0	0	17965	1783	62	5	1339	5	ZNF527	19	37880276	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	497509	37880276	21248707	671	10344										
ZNF607	84775	broad.mit.edu	37	chr19	38190458	38190458	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcatagggtttctcaacatGaactttcccatgttgagcaa	7	9	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:38190458G>T	uc002ohc.1	-	5	1170	c.574C>A	c.(574-576)CAT>AAT	p.H192N	ZNF607_uc002ohb.1_Missense_Mutation_p.H191N	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	192	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TTCTCAACATGAACTTTCCCA	0.393													1	0	4.10826e-27	0.01441	4.35021e-27	51	646										T	38190458	G	T	38190458	3	4	40	1	0	0	0	0	1	0	0	0	18030	1290	45	3	1520	3	ZNF607	19	38190458	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	310182	38190458	20938525	672	10345										
FCGBP	8857	broad.mit.edu	37	chr19	40408603	40408603	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caggagttgccgaactcattGgcgttgcctgcctgtgagcc	13	12	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:40408603G>C	uc002omp.3	-	8	4244	c.4236C>G	c.(4234-4236)GCC>GCG	p.A1412A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1412	VWFD 3.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGAACTCATTGGCGTTGCCTG	0.632													0	0	0	0.00499	0	16	44										C	40408603	G	C	40408603	2	2	40	1	0	0	0	0	0	0	0	1	5778	1335	47	4		4	FCGBP	19	40408603	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2218145	40408603	18720380	673	10346										
PSMC4	5704	broad.mit.edu	37	chr19	40480725	40480725	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttggcaaaggcggtggcacaTcacacaacaggtgagccctt	12	11	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:40480725T>C	uc002omq.2	+	6	700	c.663T>C	c.(661-663)CAT>CAC	p.H221H	PSMC4_uc002omr.2_Silent_p.H190H	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	221					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CGGTGGCACATCACACAACAG	0.597													0	0	0	0.006214	0	8	29										C	40480725	T	C	40480725	2	2	40	1	0	0	0	0	0	0	0	1	12689	1432	50	5		5	PSMC4	19	40480725	Silent	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	72122	40480725	18648258	674	10347										
BCKDHA	593	broad.mit.edu	37	chr19	41884361	41884361	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccctgaggggtttgcagttCctgtcaccgcctcttccctc	9	16	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:41884361C>T	uc002oqm.3	+	2	498	c.147C>T	c.(145-147)TTC>TTT	p.F49F	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_Silent_p.F49F|TMEM91_uc010ehq.2_Silent_p.F49F|TMEM91_uc002oql.2_Silent_p.F49F|TMEM91_uc010ehr.2_Silent_p.F49F|TMEM91_uc010ehs.2_Silent_p.F49F|TMEM91_uc010eht.2_Silent_p.F49F|TMEM91_uc002oqk.3_Silent_p.F49F|TMEM91_uc002oqn.2_Silent_p.F49F	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	Error:Variant_position_missing_in_P12694_after_alignment					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						GTTTGCAGTTCCTGTCACCGC	0.617													0	0	0	0.008871	0	19	41										T	41884361	C	T	41884361	2	4	40	1	0	0	0	0	0	0	0	1	1359	854	30	1		1	BCKDHA	19	41884361	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1403636	41884361	17244622	675	10348										
CEACAM5	1048	broad.mit.edu	37	chr19	42213827	42213827	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agggcccgcatacagtggtcGagagataatataccccaatg	11	10	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:42213827G>T	uc002ork.2	+	2	414	c.293G>T	c.(292-294)CGA>CTA	p.R98L	CEACAM5_uc010ehz.1_Missense_Mutation_p.R98L|CEACAM5_uc002orj.1_Missense_Mutation_p.R98L|CEACAM5_uc002orl.2_Missense_Mutation_p.R98L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	98	Ig-like 1.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TACAGTGGTCGAGAGATAATA	0.448													1	0	3.21399e-22	0.004878	3.38295e-22	39	229										T	42213827	G	T	42213827	3	4	40	1	0	0	0	0	1	0	0	0	3195	1058	37	3	299	3	CEACAM5	19	42213827	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	329466	42213827	16915156	676	10349										
GSK3A	2931	broad.mit.edu	37	chr19	42744116	42744116	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcccaagctaccttgaacctCttgtcctggagaaccttctt	7	14	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:42744116C>G	uc002otb.1	-	2	581	c.462G>C	c.(460-462)AAG>AAC	p.K154N	GSK3A_uc002ota.1_Missense_Mutation_p.K72N|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	154	Protein kinase.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				CCTTGAACCTCTTGTCCTGGA	0.567													0	0	0	0.000602	0	5	33										G	42744116	C	G	42744116	3	3	40	1	0	0	0	0	1	0	0	0	6823	912	32	1	1029	1	GSK3A	19	42744116	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	530289	42744116	16384867	677	10350										
ERCC2	2068	broad.mit.edu	37	chr19	45873455	45873455	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctcggggtagatgtagtcgTacgggaagtagaccaggagc	17	7	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:45873455T>C	uc002pbj.2	-	2	88	c.41A>G	c.(40-42)TAC>TGC	p.Y14C	ERCC2_uc010ejz.2_Missense_Mutation_p.Y14C|ERCC2_uc002pbk.2_5'UTR|ERCC2_uc002pbl.3_5'UTR|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	14	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GATGTAGTCGTACGGGAAGTA	0.682			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001168	0	4	27										C	45873455	T	C	45873455	3	2	40	1	0	0	0	0	1	0	0	0	5213	1638	57	5	2386	5	ERCC2	19	45873455	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	3129339	45873455	13255528	678	10351										
PPP1R13L	10848	broad.mit.edu	37	chr19	45899596	45899596	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cccgggcctccaccactcacGttcatagctcgctgtctgcg	9	18	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:45899596G>A	uc002pbn.2	-	5	888	c.811C>T	c.(811-813)CGC>TGC	p.R271C	PPP1R13L_uc002pbo.2_Missense_Mutation_p.R271C|PPP1R13L_uc002pbp.2_Missense_Mutation_p.R271C	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	271	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CACCACTCACGTTCATAGCTC	0.652													0	0	0	0.004007	0	15	41										A	45899596	G	A	45899596	3	1	40	1	0	0	0	0	1	0	0	0	12358	1159	40	2	1711	2	PPP1R13L	19	45899596	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	26141	45899596	13229387	679	10352										
FAM83E	54854	broad.mit.edu	37	chr19	49116416	49116416	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttggccactgtccagtcttCagctgccgctgccaagccct	9	17	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49116416C>T	uc002pjn.2	-	1	279	c.214G>A	c.(214-216)GAA>AAA	p.E72K		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	72										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GTCCAGTCTTCAGCTGCCGCT	0.672													0	0	0	0.006122	0	15	8										T	49116416	C	T	49116416	3	4	40	1	0	0	0	0	1	0	0	0	5637	835	29	1	1242	1	FAM83E	19	49116416	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3216820	49116416	10012567	680	10353										
PPP1R15A	23645	broad.mit.edu	37	chr19	49377076	49377076	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccgtggaggaggaggacgatGaagaagctgtaaagaaagaa	16	4	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49377076G>A	uc002pky.3	+	2	855	c.586G>A	c.(586-588)GAA>AAA	p.E196K		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	196	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GGAGGACGATGAAGAAGCTGT	0.532													0	0	0	0.00623	0	40	56										A	49377076	G	A	49377076	3	1	40	1	0	0	0	0	1	0	0	0	12363	1291	45	1	588	1	PPP1R15A	19	49377076	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	260660	49377076	9751907	681	10354										
GYS1	2997	broad.mit.edu	37	chr19	49481249	49481249	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cagcatcttgttcatgtcggGaaggctcccactgcaaggca	11	12	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49481249G>A	uc002plp.2	-	10	1481	c.1240C>T	c.(1240-1242)CCC>TCC	p.P414S	GYS1_uc010xzy.1_Missense_Mutation_p.P47S|GYS1_uc010emm.2_Missense_Mutation_p.P350S|GYS1_uc010xzz.1_Missense_Mutation_p.P334S|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	414					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TTCATGTCGGGAAGGCTCCCA	0.542													0	0	0	0.01441	0	66	89										A	49481249	G	A	49481249	3	1	40	1	0	0	0	0	1	0	0	0	6912	1174	41	1	1001	1	GYS1	19	49481249	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	104173	49481249	9647734	682	10355										
HRC	3270	broad.mit.edu	37	chr19	49658329	49658329	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtggaggtggtggcgaagctCtgctgatgcctcctcggaga	17	9	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:49658329C>T	uc002pmv.2	-	1	353	c.166G>A	c.(166-168)GAG>AAG	p.E56K	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	56					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TGGCGAAGCTCTGCTGATGCC	0.597													0	0	0	0.01441	0	58	121										T	49658329	C	T	49658329	3	4	40	1	0	0	0	0	1	0	0	0	7352	922	32	1	1957	1	HRC	19	49658329	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	177080	49658329	9470654	683	10356										
ZNF320	162967	broad.mit.edu	37	chr19	53383882	53383882	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gatggtttgctatactcattGcacttgaaacaattgtctcc	7	9	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:53383882G>A	uc002qag.2	-	4	1688	c.1497C>T	c.(1495-1497)TGC>TGT	p.C499C	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.C445C|ZNF320_uc002qai.2_Silent_p.C499C	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TATACTCATTGCACTTGAAAC	0.368													0	0	0	0.004656	0	22	140										A	53383882	G	A	53383882	2	1	40	1	0	0	0	0	0	0	0	1	17836	1311	46	2		2	ZNF320	19	53383882	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3725553	53383882	5745101	684	10357										
ZNF816A	125893	broad.mit.edu	37	chr19	53454109	53454109	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtaaggtttctctccagtatGaagtctacgatggcatacaa	9	8	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:53454109G>A	uc002qal.1	-	5	1220	c.919C>T	c.(919-921)CAT>TAT	p.H307Y	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.H291Y	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	307	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TCTCCAGTATGAAGTCTACGA	0.428													0	0	0	0.01441	0	152	185										A	53454109	G	A	53454109	3	1	40	1	0	0	0	0	1	0	0	0	18174	1290	45	1	1040	1	ZNF816A	19	53454109	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	70227	53454109	5674874	685	10358										
ZNF160	90338	broad.mit.edu	37	chr19	53573363	53573363	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtcatctctccattgacactCaaaatcatgcacatttttct	3	12	5	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:53573363C>G	uc010eqk.2	-	7	840	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	ZNF160_uc002qaq.3_Missense_Mutation_p.E142Q|ZNF160_uc002qar.3_Missense_Mutation_p.E142Q	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	142					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		CATTGACACTCAAAATCATGC	0.423													0	0	0	0.01441	0	125	154										G	53573363	C	G	53573363	3	3	40	1	0	0	0	0	1	0	0	0	17736	835	29	1	2036	1	ZNF160	19	53573363	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	119254	53573363	5555620	686	10359										
RPS9	6203	broad.mit.edu	37	chr19	54705081	54705081	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcccggagctgggtttgtcGcaaaacttatgtgaccccgc	13	12	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:54705081G>C	uc002qdx.2	+	2	85	c.29G>C	c.(28-30)CGC>CCC	p.R10P	RPS9_uc002qdy.2_Missense_Mutation_p.R10P|RPS9_uc002qdz.2_Missense_Mutation_p.R10P|RPS9_uc002qea.2_Missense_Mutation_p.R10P|RPS9_uc002qeb.2_Missense_Mutation_p.R10P|RPS9_uc002qec.2_RNA|RPS9_uc002qed.1_Missense_Mutation_p.R10P	NM_001013	NP_001004	P46781	RS9_HUMAN	ribosomal protein S9	10					endocrine pancreas development|positive regulation of cell proliferation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome|translation regulator activity			breast(1)	1	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.18)		TGGGTTTGTCGCAAAACTTAT	0.617													0	0	0	0.00278	0	22	48										C	54705081	G	C	54705081	3	2	40	1	0	0	0	0	1	0	0	0	13662	1087	38	4	31	4	RPS9	19	54705081	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1131718	54705081	4423902	687	10360										
TNNI3	7137	broad.mit.edu	37	chr19	55667621	55667621	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccagcggctggcagcgggtgCtcagagcgcgccccttctct	14	16	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:55667621C>T	uc002qjg.3	-	5	230	c.230G>A	c.(229-231)AGC>AAC	p.S77N	TNNI3_uc010yft.1_Missense_Mutation_p.S69N	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac	77	Involved in binding TNC.				cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GCAGCGGGTGCTCAGAGCGCG	0.657													0	0	0	0.000602	0	4	16										T	55667621	C	T	55667621	3	4	40	1	0	0	0	0	1	0	0	0	16325	797	28	2	418	2	TNNI3	19	55667621	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	962540	55667621	3461362	688	10361										
ZNF460	10794	broad.mit.edu	37	chr19	57802811	57802811	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttttgtcttgcataacaagaGccacaatgagaagaaaccct	7	9	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:57802811G>C	uc002qog.2	+	3	1224	c.902G>C	c.(901-903)AGC>ACC	p.S301T	ZNF460_uc010ygv.1_Missense_Mutation_p.S260T	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	301	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CATAACAAGAGCCACAATGAG	0.473													0	0	0	0.014323	0	22	141										C	57802811	G	C	57802811	3	2	40	1	0	0	0	0	1	0	0	0	17921	971	34	4	912	4	ZNF460	19	57802811	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2135190	57802811	1326172	689	10362										
ZSCAN1	284312	broad.mit.edu	37	chr19	58565117	58565117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctgggtcacccacttcatcGagcaccagaagacccatcgc	8	17	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:58565117G>A	uc002qrc.1	+	6	1172	c.925G>A	c.(925-927)GAG>AAG	p.E309K		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	309	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCACTTCATCGAGCACCAGAA	0.627													0	0	0	0.003954	0	25	39										A	58565117	G	A	58565117	3	1	40	1	0	0	0	0	1	0	0	0	18223	1059	37	1	939	1	ZSCAN1	19	58565117	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	762306	58565117	563866	690	10363										
SLC27A5	10998	broad.mit.edu	37	chr19	59011983	59011983	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gacttcccagatccgaatagGaccgaagcgctgctggaagg	13	11	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr19:59011983G>A	uc002qtc.2	-	5	1383	c.1273C>T	c.(1273-1275)CCT>TCT	p.P425S	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	425	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		ATCCGAATAGGACCGAAGCGC	0.587													0	0	0	0.004289	0	35	48										A	59011983	G	A	59011983	3	1	40	1	0	0	0	0	1	0	0	0	14529	1174	41	1	823	1	SLC27A5	19	59011983	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	446866	59011983	117000	691	10364										
NOP56	10528	broad.mit.edu	37	chr20	2636004	2636004	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tatcactttccggagctggtGaagatcatcaacgacaatgc	9	10	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:2636004G>A	uc002wgh.2	+	6	656	c.603G>A	c.(601-603)GTG>GTA	p.V201V	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_Silent_p.V35V|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	201					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						CGGAGCTGGTGAAGATCATCA	0.522													0	0	0	0.004007	0	15	83										A	2636004	G	A	2636004	2	1	40	1	0	0	0	0	0	0	0	1	10539	1277	45	1		1	NOP56	20	2636004	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		2636004	60389516	692	10365										
PLCB1	23236	broad.mit.edu	37	chr20	8113380	8113380	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcctcaagaagggcaccaaaTtcgtcaagtgggatgatgta	12	8	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:8113380T>C	uc002wnb.2	+	1	85	c.82T>C	c.(82-84)TTC>CTC	p.F28L	PLCB1_uc010zrb.1_Intron|PLCB1_uc010gbv.1_Missense_Mutation_p.F28L|PLCB1_uc002wmz.1_Missense_Mutation_p.F28L|PLCB1_uc002wna.2_Missense_Mutation_p.F28L	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	28				MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDD -> MGS LQGIATKILIRILSDALIRKETDLKS (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GGGCACCAAATTCGTCAAGTG	0.682													0	0	0	0.001168	0	5	5										C	8113380	T	C	8113380	3	2	40	1	0	0	0	0	1	0	0	0	12027	1493	52	5	84	5	PLCB1	20	8113380	Missense_Mutation	SNP	T	TCGA-DK-A1A3-01A-11D-A13W-08	5477376	8113380	54912140	693	10366										
TPX2	22974	broad.mit.edu	37	chr20	30385318	30385318	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aagagaagaaatcagttgctGgtagtattatatgtactctg	10	4	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:30385318G>A	uc002wwp.1	+	16	2643	c.1945G>A	c.(1945-1947)GAG>AAG	p.E649K	TPX2_uc010gdv.1_Missense_Mutation_p.E685K	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	649					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			ATCAGTTGCTGGTAGTATTAT	0.463													0	0	0	0.010818	0	32	121										A	30385318	G	A	30385318	3	1	40	1	0	0	0	0	1	0	0	0	16429	1362	47	2	1999	2	TPX2	20	30385318	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	22271938	30385318	32640202	694	10367										
FOXS1	2307	broad.mit.edu	37	chr20	30433105	30433105	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcctggcttgcggtcatcgcGgggcaccttgacaaagcact	13	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:30433105G>A	uc002wwt.1	-	1	316	c.241C>T	c.(241-243)CGC>TGC	p.R81C		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	81	Fork-head.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						CGGTCATCGCGGGGCACCTTG	0.637													0	0	0	0.003163	0	14	23										A	30433105	G	A	30433105	3	1	40	1	0	0	0	0	1	0	0	0	6035	1116	39	2	755	2	FOXS1	20	30433105	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	47787	30433105	32592415	695	10368										
DNMT3B	1789	broad.mit.edu	37	chr20	31376814	31376814	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtttggcgatggcaagttctCcgaggtgagtccggggaagg	18	7	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:31376814C>G	uc002wyc.2	+	7	1130	c.809C>G	c.(808-810)TCC>TGC	p.S270C	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.S270C|DNMT3B_uc002wye.2_Missense_Mutation_p.S270C|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.S228C|DNMT3B_uc010zua.1_Missense_Mutation_p.S194C|DNMT3B_uc002wyf.2_Missense_Mutation_p.S282C|DNMT3B_uc002wyg.2_5'Flank	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	270	PWWP.|Interaction with DNMT1 and DNMT3A.		S -> P (in ICF).		negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						GGCAAGTTCTCCGAGGTGAGT	0.607													0	0	0	0.010504	0	20	25										G	31376814	C	G	31376814	3	3	40	1	0	0	0	0	1	0	0	0	4677	855	30	1	871	1	DNMT3B	20	31376814	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	943709	31376814	31648706	696	10369										
RALY	22913	broad.mit.edu	37	chr20	32659982	32659982	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcaacacagctctggtgaaGaaatcagatgtggagaccat	10	9	3	4	rs114080584	by1000genomes	TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:32659982G>C	uc002xab.2	+	3	400	c.102G>C	c.(100-102)AAG>AAC	p.K34N	RALY_uc010zui.1_Missense_Mutation_p.K34N|RALY_uc002xac.2_Missense_Mutation_p.K34N|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.K34N	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	34	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						CTCTGGTGAAGAAATCAGATG	0.488													0	0	0	0.010504	0	21	114										C	32659982	G	C	32659982	3	2	40	1	0	0	0	0	1	0	0	0	13019	933	33	1	104	1	RALY	20	32659982	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1283168	32659982	30365538	697	10370										
RALY	22913	broad.mit.edu	37	chr20	32664519	32664519	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cactcccagtaaagagcagtGagctgcaggccatcaagacg	11	12	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:32664519G>A	uc002xab.2	+	7	854	c.556G>A	c.(556-558)GAG>AAG	p.E186K	RALY_uc002xac.2_Missense_Mutation_p.E170K|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.E186K	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	186						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						AAAGAGCAGTGAGCTGCAGGC	0.572													0	0	0	0.006214	0	8	45										A	32664519	G	A	32664519	3	1	40	1	0	0	0	0	1	0	0	0	13019	1291	45	1	574	1	RALY	20	32664519	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4537	32664519	30361001	698	10371										
EPB41L1	2036	broad.mit.edu	37	chr20	34782172	34782172	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cctcggtcagcgagaaccatGatgcagggcctgacggtgac	14	12	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:34782172G>A	uc002xfb.2	+	12	1510	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	EPB41L1_uc002xeu.2_Missense_Mutation_p.D385N|EPB41L1_uc010zvo.1_Missense_Mutation_p.D447N|EPB41L1_uc002xev.2_Missense_Mutation_p.D447N|EPB41L1_uc002xew.2_Missense_Mutation_p.D350N|EPB41L1_uc002xex.2_Missense_Mutation_p.D416N|EPB41L1_uc002xey.2_Missense_Mutation_p.D374N|EPB41L1_uc002xez.2_Missense_Mutation_p.D385N	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	447					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CGAGAACCATGATGCAGGGCC	0.597													0	0	0	0.00308	0	6	28										A	34782172	G	A	34782172	3	1	40	1	0	0	0	0	1	0	0	0	5152	1290	45	1	1381	1	EPB41L1	20	34782172	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2117653	34782172	28243348	699	10372										
DHX35	60625	broad.mit.edu	37	chr20	37621005	37621005	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctttgattcttagtgtcatCatgctggatgaagcccacga	9	9	4	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:37621005C>T	uc002xjh.2	+	7	530	c.519C>T	c.(517-519)ATC>ATT	p.I173I	DHX35_uc010zwa.1_Silent_p.I18I|DHX35_uc010zwb.1_Silent_p.I18I|DHX35_uc010zwc.1_Silent_p.I142I	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	173	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TTAGTGTCATCATGCTGGATG	0.433													0	0	0	0.01441	0	49	126										T	37621005	C	T	37621005	2	4	40	1	0	0	0	0	0	0	0	1	4508	816	29	1		1	DHX35	20	37621005	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2838833	37621005	25404515	700	10373										
CHD6	84181	broad.mit.edu	37	chr20	40065975	40065975	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cttctttatctgtgttgcctCtaaataaaagtaaaaaaagg	6	6	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:40065975C>T	uc002xka.1	-	27	4186	c.4008_splice	c.e27-1	p.R1336_splice	CHD6_uc002xkb.1_Intron	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6						chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGTGTTGCCTCTAAATAAAAG	0.264													0	0	0	0.00623	0	41	84										T	40065975	C	T	40065975	5	4	40	1	0	0	0	0	0	0	1	0	3329	927	32	1	4184	1	CHD6	20	40065975	Splice_Site	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2444970	40065975	22959545	701	10374										
SGK2	10110	broad.mit.edu	37	chr20	42196637	42196637	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agtccatcttaaagaagaaaGaggtaccagagctcgggcac	11	9	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:42196637G>C	uc002xkv.2	+	4	625	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.E76Q|SGK2_uc010ggm.2_Missense_Mutation_p.E76Q|SGK2_uc002xks.2_Missense_Mutation_p.E76Q|SGK2_uc002xku.2_Missense_Mutation_p.E76Q|SGK2_uc002xkq.1_Missense_Mutation_p.E76Q	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	136	Protein kinase.|Nuclear localization signal (By similarity).				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AAAGAAGAAAGAGGTACCAGA	0.502													0	0	0	0.008291	0	9	59										C	42196637	G	C	42196637	3	2	40	1	0	0	0	0	1	0	0	0	14209	943	33	1	420	1	SGK2	20	42196637	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2130662	42196637	20828883	702	10375										
SERINC3	10955	broad.mit.edu	37	chr20	43141486	43141486	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctttacttgtttttactttGaacatgagcagagaaaagac	7	6	1	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:43141486G>C	uc002xme.2	-	3	485	c.351C>G	c.(349-351)TTC>TTG	p.F117L	SERINC3_uc002xmf.1_Missense_Mutation_p.F117L|SERINC3_uc010ggs.1_Missense_Mutation_p.F110L|SERINC3_uc010zwp.1_Missense_Mutation_p.F62L	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	117	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			TTTTTACTTTGAACATGAGCA	0.398													0	0	0	0.004007	0	17	108										C	43141486	G	C	43141486	3	2	40	1	0	0	0	0	1	0	0	0	14081	1281	45	1	1102	1	SERINC3	20	43141486	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	944849	43141486	19884034	703	10376										
PKIG	11142	broad.mit.edu	37	chr20	43243233	43243233	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcctcctactcggacttcatCtcctgtgaccggacaggccg	9	16	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:43243233C>T	uc002xmg.2	+	5	565	c.36C>T	c.(34-36)ATC>ATT	p.I12I	PKIG_uc002xmh.2_Silent_p.I12I|PKIG_uc002xmi.2_Silent_p.I12I	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	12							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			CGGACTTCATCTCCTGTGACC	0.617													0	0	0	0.008361	0	31	74										T	43243233	C	T	43243233	2	4	40	1	0	0	0	0	0	0	0	1	11975	903	32	1		1	PKIG	20	43243233	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	101747	43243233	19782287	704	10377										
RIMS4	140730	broad.mit.edu	37	chr20	43399923	43399923	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gccccacacttacttgccctCtgagccatagctgttcatgc	7	16	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:43399923C>G	uc002xms.2	-	2	229	c.229G>C	c.(229-231)GAG>CAG	p.E77Q	RIMS4_uc010ggu.2_Missense_Mutation_p.E78Q	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	77					exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				TACTTGCCCTCTGAGCCATAG	0.637													0	0	0	0.003163	0	15	67										G	43399923	C	G	43399923	3	3	40	1	0	0	0	0	1	0	0	0	13370	922	32	1	600	1	RIMS4	20	43399923	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	156690	43399923	19625597	705	10378										
ZMYND8	23613	broad.mit.edu	37	chr20	45923508	45923508	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	actctgggtctcgatgcattCtgctactgtaattttctaca	7	10	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:45923508C>T	uc002xta.1	-	5	663	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ZMYND8_uc010ghr.1_Missense_Mutation_p.E112K|ZMYND8_uc002xst.1_Missense_Mutation_p.E112K|ZMYND8_uc002xsu.1_Missense_Mutation_p.E137K|ZMYND8_uc002xsv.1_Missense_Mutation_p.E112K|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.E112K|ZMYND8_uc002xsz.1_Intron|ZMYND8_uc010zxy.1_Missense_Mutation_p.E164K|ZMYND8_uc002xtb.1_Missense_Mutation_p.E157K|ZMYND8_uc002xss.2_Missense_Mutation_p.E137K|ZMYND8_uc010zxz.1_Missense_Mutation_p.E132K|ZMYND8_uc002xtc.1_Missense_Mutation_p.E157K|ZMYND8_uc002xtd.1_Missense_Mutation_p.E132K|ZMYND8_uc002xte.1_Missense_Mutation_p.E137K|ZMYND8_uc010zya.1_Missense_Mutation_p.E137K|ZMYND8_uc002xtf.1_Missense_Mutation_p.E157K|ZMYND8_uc002xtg.2_Missense_Mutation_p.E131K|ZMYND8_uc010ghs.1_Missense_Mutation_p.E131K	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	137							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCGATGCATTCTGCTACTGTA	0.383													0	0	0	0.01441	0	92	227										T	45923508	C	T	45923508	3	4	40	1	0	0	0	0	1	0	0	0	17708	922	32	1	3173	1	ZMYND8	20	45923508	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	2523585	45923508	17102012	706	10379										
CSE1L	1434	broad.mit.edu	37	chr20	47704592	47704592	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caagaagccataatcccctaCatccctactctcatcactca	2	17	3	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:47704592C>T	uc002xty.2	+	17	1904	c.1770C>T	c.(1768-1770)TAC>TAT	p.Y590Y	CSE1L_uc010zyg.1_Silent_p.Y373Y|CSE1L_uc010ghx.2_Silent_p.Y534Y|CSE1L_uc010ghy.2_Silent_p.Y211Y|CSE1L_uc010zyh.1_Silent_p.Y239Y	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	590					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TAATCCCCTACATCCCTACTC	0.348													0	0	0	0.006999	0	36	106										T	47704592	C	T	47704592	2	4	40	1	0	0	0	0	0	0	0	1	3930	489	17	2		2	CSE1L	20	47704592	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1781084	47704592	15320928	707	10380										
SLC9A8	23315	broad.mit.edu	37	chr20	48503324	48503324	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tcggagcacctgtcggagctCacggaggaggagtacgaggc	17	10	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:48503324C>T	uc002xuv.1	+	15	1737	c.1527C>T	c.(1525-1527)CTC>CTT	p.L509L	SLC9A8_uc010zym.1_Silent_p.L209L|SLC9A8_uc010gid.2_Silent_p.L133L	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	509						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TGTCGGAGCTCACGGAGGAGG	0.647													0	0	0	0.004656	0	23	61										T	48503324	C	T	48503324	2	4	40	1	0	0	0	0	0	0	0	1	14720	813	29	1		1	SLC9A8	20	48503324	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	798732	48503324	14522196	708	10381										
ATP9A	10079	broad.mit.edu	37	chr20	50255994	50255994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gctgcatggaagactggtctCggcccaccagggttaagccc	13	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:50255994C>T	uc002xwg.1	-	15	1556	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	ATP9A_uc010gih.1_Missense_Mutation_p.R383Q|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	519	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						AGACTGGTCTCGGCCCACCAG	0.547											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00632	0	29	88										T	50255994	C	T	50255994	3	4	40	1	0	0	0	0	1	0	0	0	1198	884	31	1	1643	1	ATP9A	20	50255994	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	1752670	50255994	12769526	709	10382										
TSHZ2	128553	broad.mit.edu	37	chr20	51871960	51871960	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgggtcccctgaaggaggagGagaagctgatgaaagagggc	18	6	0	5			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:51871960G>T	uc002xwo.2	+	2	2919	c.1963G>T	c.(1963-1965)GAG>TAG	p.E655*		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	655					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GAAGGAGGAGGAGAAGCTGAT	0.592													1	0	3.09899e-07	0.004482	3.18577e-07	9	69										T	51871960	G	T	51871960	4	4	40	1	0	0	0	0	0	1	0	0	16621	1175	41	3	1969	3	TSHZ2	20	51871960	Nonsense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1615966	51871960	11153560	710	10383										
GNAS	2778	broad.mit.edu	37	chr20	57480468	57480468	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcatgccaaggctctgtggGaggatgaaggagtgcgtgcc	17	8	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:57480468G>C	uc002xzw.2	+	6	2677	c.2392G>C	c.(2392-2394)GAG>CAG	p.E798Q	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.E96Q|GNAS_uc002xzx.2_Missense_Mutation_p.E96Q|GNAS_uc010gjr.2_Missense_Mutation_p.E46Q|GNAS_uc002xzy.2_Missense_Mutation_p.E81Q|GNAS_uc002yaa.2_Missense_Mutation_p.E141Q|GNAS_uc010zzt.1_Missense_Mutation_p.E156Q|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.E46Q|GNAS_uc002yae.2_Missense_Mutation_p.E80Q	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	155					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GGCTCTGTGGGAGGATGAAGG	0.473			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	0.006214	0	8	64										C	57480468	G	C	57480468	3	2	40	1	0	0	0	0	1	0	0	0	6510	1175	41	1	3302	1	GNAS	20	57480468	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5608508	57480468	5545052	711	10384										
PRIC285	85441	broad.mit.edu	37	chr20	62195447	62195447	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tggtggccgaggtgcagtgaCaggggcacccggtccccatg	17	12	0	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:62195447C>T	uc002yfm.2	-	9	5620	c.4728G>A	c.(4726-4728)CTG>CTA	p.L1576L	PRIC285_uc002yfl.1_Silent_p.L1007L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1576					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGTGCAGTGACAGGGGCACCC	0.711													0	0	0	0.010729	0	10	16										T	62195447	C	T	62195447	2	4	40	1	0	0	0	0	0	0	0	1	12485	465	17	2		2	PRIC285	20	62195447	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4714979	62195447	830073	712	10385										
MYT1	4661	broad.mit.edu	37	chr20	62838960	62838960	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgtgcaggaaggagccccgtCaagtcccattttggatccaa	11	11	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr20:62838960C>G	uc002yii.2	+	7	775	c.411C>G	c.(409-411)GTC>GTG	p.V137V	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	137					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GGAGCCCCGTCAAGTCCCATT	0.582													0	0	0	0.008871	0	18	117										G	62838960	C	G	62838960	2	3	40	1	0	0	0	0	0	0	0	1	10106	813	29	1		1	MYT1	20	62838960	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	643513	62838960	186560	713	10386										
SFRS15	57466	broad.mit.edu	37	chr21	33044531	33044531	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcatgggacggggcggcatCaaagggaaccgctgtaagtg	18	8	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:33044531C>G	uc002ypd.2	-	20	3051	c.2625G>C	c.(2623-2625)TTG>TTC	p.L875F	SFRS15_uc002ype.2_Missense_Mutation_p.L853F|SFRS15_uc010glu.2_Missense_Mutation_p.L860F	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	875						nucleus	nucleotide binding|RNA binding				0						GGGGCGGCATCAAAGGGAACC	0.632													0	0	0	0.014323	0	22	73										G	33044531	C	G	33044531	3	3	40	1	0	0	0	0	1	0	0	0	14171	825	29	1	822	1	SFRS15	21	33044531	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		33044531	15085364	714	10387										
ITSN1	6453	broad.mit.edu	37	chr21	35153820	35153820	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aaaacagatactcaatgaccAattaaaacaagttcagcaga	5	8	2	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:35153820A>G	uc002yta.1	+	15	1920	c.1652A>G	c.(1651-1653)CAA>CGA	p.Q551R	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.Q551R|ITSN1_uc010gmg.2_Missense_Mutation_p.Q514R|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.Q551R|ITSN1_uc010gmi.2_Missense_Mutation_p.Q514R|ITSN1_uc010gmj.2_Missense_Mutation_p.Q435R|ITSN1_uc002ysy.2_Missense_Mutation_p.Q551R|ITSN1_uc002ysx.2_Missense_Mutation_p.Q514R|ITSN1_uc002ytb.1_Missense_Mutation_p.Q551R|ITSN1_uc002ytc.1_Missense_Mutation_p.Q551R|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.Q514R|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.Q551R|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.Q485R	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	551	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CTCAATGACCAATTAAAACAA	0.299													0	0	0	0.006122	0	15	122										G	35153820	A	G	35153820	3	3	40	1	0	0	0	0	1	0	0	0	7926	130	5	5	1706	5	ITSN1	21	35153820	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	2109289	35153820	12976075	715	10388										
MORC3	23515	broad.mit.edu	37	chr21	37741509	37741509	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcaggttgagtttgtgggtGacagtgaaccttgtggccag	15	6	1	3			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:37741509G>A	uc002yvi.2	+	15	1919	c.1843G>A	c.(1843-1845)GAC>AAC	p.D615N		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	615					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GTTTGTGGGTGACAGTGAACC	0.473													0	0	0	0.01441	0	70	130										A	37741509	G	A	37741509	3	1	40	1	0	0	0	0	1	0	0	0	9703	1290	45	1	1901	1	MORC3	21	37741509	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2587689	37741509	10388386	716	10389										
TTC3	7267	broad.mit.edu	37	chr21	38519889	38519889	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agatccagatatacataactGatccagactttaaggtaaat	6	7	0	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:38519889G>A	uc002yvz.2	+	22	2107	c.2002G>A	c.(2002-2004)GAT>AAT	p.D668N	TTC3_uc011aee.1_Missense_Mutation_p.D358N|TTC3_uc002ywa.2_Missense_Mutation_p.D668N|TTC3_uc002ywb.2_Missense_Mutation_p.D668N|TTC3_uc010gnf.2_Missense_Mutation_p.D433N|TTC3_uc002ywc.2_Missense_Mutation_p.D358N|TTC3_uc011aed.1_Missense_Mutation_p.D358N	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	668					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				ATACATAACTGATCCAGACTT	0.378													0	0	0	0.01441	0	58	179										A	38519889	G	A	38519889	3	1	40	1	0	0	0	0	1	0	0	0	16694	1290	45	1	2084	1	TTC3	21	38519889	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	778380	38519889	9610006	717	10390										
ERG	2078	broad.mit.edu	37	chr21	39755527	39755527	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agcccatgtacgggaggtctGaggggtacttgtacagagat	15	7	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:39755527G>A	uc010gnw.2	-	12	1554	c.1259C>T	c.(1258-1260)TCA>TTA	p.S420L	ERG_uc002yxa.2_Missense_Mutation_p.S413L|ERG_uc011aek.1_Missense_Mutation_p.S321L|ERG_uc010gnv.2_Missense_Mutation_p.S297L|ERG_uc010gnx.2_Missense_Mutation_p.S396L|ERG_uc011ael.1_Missense_Mutation_p.S420L|ERG_uc002yxb.2_Missense_Mutation_p.S396L	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	420					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CGGGAGGTCTGAGGGGTACTT	0.597													0	0	0	0.01441	0	62	71										A	39755527	G	A	39755527	3	1	40	1	0	0	0	0	1	0	0	0	5222	1294	45	1	205	1	ERG	21	39755527	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1235638	39755527	8374368	718	10391										
BRWD1	54014	broad.mit.edu	37	chr21	40559037	40559037	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctagctctttttcactttcaGaatttatggttgtatcatcc	5	9	4	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:40559037G>A	uc002yxk.1	-	42	7017	c.6878C>T	c.(6877-6879)TCT>TTT	p.S2293F	BRWD1_uc010goc.1_Missense_Mutation_p.S936F	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	2293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTCACTTTCAGAATTTATGGT	0.343													0	0	0	0.01441	0	56	146										A	40559037	G	A	40559037	3	1	40	1	0	0	0	0	1	0	0	0	1525	942	33	1	88	1	BRWD1	21	40559037	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	803510	40559037	7570858	719	10392										
PCNT	5116	broad.mit.edu	37	chr21	47851851	47851851	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ctcagcagcagcttgaggctGaggctcagaagcactgtgag	14	10	2	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr21:47851851G>C	uc002zji.3	+	38	8580	c.8473G>C	c.(8473-8475)GAG>CAG	p.E2825Q	PCNT_uc002zjj.2_Missense_Mutation_p.E2707Q	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2825	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCTTGAGGCTGAGGCTCAGAA	0.572													0	0	0	0.004482	0	9	45										C	47851851	G	C	47851851	3	2	40	1	0	0	0	0	1	0	0	0	11590	1291	45	1	8623	1	PCNT	21	47851851	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	7292814	47851851	278044	720	10393										
BCL2L13	23786	broad.mit.edu	37	chr22	18209590	18209590	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgaccacttcctggcagtctGagagcttacctgtgtcactg	10	12	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:18209590G>C	uc002zmw.2	+	7	966	c.748G>C	c.(748-750)GAG>CAG	p.E250Q	BCL2L13_uc002zmx.2_Missense_Mutation_p.E88Q|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.E88Q|BCL2L13_uc011agk.1_Missense_Mutation_p.E126Q|BCL2L13_uc010gqz.2_5'UTR|BCL2L13_uc002zmz.2_Missense_Mutation_p.E88Q|BCL2L13_uc002zna.2_5'UTR	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	250	A.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTGGCAGTCTGAGAGCTTACC	0.537													0	0	0	0.00308	0	8	52										C	18209590	G	C	18209590	3	2	40	1	0	0	0	0	1	0	0	0	1371	1291	45	1	770	1	BCL2L13	22	18209590	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		18209590	33094976	721	10394										
MAPK1	5594	broad.mit.edu	37	chr22	22161970	22161970	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tacacatctttcatttgctcGatggttggtgctcgaataat	8	8	2	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:22161970G>A	uc002zvn.2	-	2	525	c.285C>T	c.(283-285)ATC>ATT	p.I95I	MAPK1_uc002zvo.2_Silent_p.I95I|MAPK1_uc010gtk.1_Silent_p.I95I	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	95	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	TCATTTGCTCGATGGTTGGTG	0.403													0	0	0	0.00308	0	8	110										A	22161970	G	A	22161970	2	1	40	1	0	0	0	0	0	0	0	1	9271	1048	37	1		1	MAPK1	22	22161970	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	3952380	22161970	29142596	722	10395										
ZNF280A	129025	broad.mit.edu	37	chr22	22868615	22868615	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aacactgaaggaccctccttCtgctgtgcctccaacaatga	7	14	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:22868615C>T	uc002zwe.2	-	2	1593	c.1340G>A	c.(1339-1341)AGA>AAA	p.R447K	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		GACCCTCCTTCTGCTGTGCCT	0.413													0	0	0	0.013726	0	33	143										T	22868615	C	T	22868615	3	4	40	1	0	0	0	0	1	0	0	0	17811	913	32	1	292	1	ZNF280A	22	22868615	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	706645	22868615	28435951	723	10396										
CRYBA4	1413	broad.mit.edu	37	chr22	27019252	27019252	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcggcacgagttcacggccGagtgccccagcgtgctggag	17	13	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:27019252G>C	uc003acz.3	+	3	129	c.94G>C	c.(94-96)GAG>CAG	p.E32Q		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	32	Beta/gamma crystallin 'Greek key' 1.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						GTTCACGGCCGAGTGCCCCAG	0.592													0	0	0	0.003163	0	15	90										C	27019252	G	C	27019252	3	2	40	1	0	0	0	0	1	0	0	0	3909	1059	37	1	100	1	CRYBA4	22	27019252	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	4150637	27019252	24285314	724	10397										
MYH9	4627	broad.mit.edu	37	chr22	36681274	36681274	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccctccatctcctgcagcttGaccttaagctccttgttctg	6	16	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:36681274G>A	uc003apg.2	-	38	5607	c.5376C>T	c.(5374-5376)GTC>GTT	p.V1792V		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1792	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCTGCAGCTTGACCTTAAGCT	0.587			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.004656	0	26	88										A	36681274	G	A	36681274	2	1	40	1	0	0	0	0	0	0	0	1	10042	1277	45	1		1	MYH9	22	36681274	Silent	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	9662022	36681274	14623292	725	10398										
TCF20	6942	broad.mit.edu	37	chr22	42609885	42609885	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tctgaggagtcagggcatcaGaaagtaacatgtgctggaca	13	7	3	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:42609885G>T	uc003bcj.1	-	1	1561	c.1427C>A	c.(1426-1428)TCT>TAT	p.S476Y	TCF20_uc003bck.1_Missense_Mutation_p.S476Y|TCF20_uc003bnt.2_Missense_Mutation_p.S476Y	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CAGGGCATCAGAAAGTAACAT	0.478													1	0	1.55811e-20	0.008361	1.63806e-20	31	197										T	42609885	G	T	42609885	3	4	40	1	0	0	0	0	1	0	0	0	15687	942	33	3	4493	3	TCF20	22	42609885	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	5928611	42609885	8694681	726	10399										
TCF20	6942	broad.mit.edu	37	chr22	42610021	42610021	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccctttgaagcctgcagcatGagaattaggactgggcatca	11	10	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:42610021G>C	uc003bcj.1	-	1	1425	c.1291C>G	c.(1291-1293)CAT>GAT	p.H431D	TCF20_uc003bck.1_Missense_Mutation_p.H431D|TCF20_uc003bnt.2_Missense_Mutation_p.H431D	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CCTGCAGCATGAGAATTAGGA	0.488													0	0	0	0.005443	0	27	120										C	42610021	G	C	42610021	3	2	40	1	0	0	0	0	1	0	0	0	15687	1290	45	1	4629	1	TCF20	22	42610021	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	136	42610021	8694545	727	10400										
MCAT	27349	broad.mit.edu	37	chr22	43538972	43538972	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtttctcgacagcggccagcGatgccacgaagatcgcgggc	14	13	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:43538972G>A	uc003bdl.1	-	1	432	c.383C>T	c.(382-384)TCG>TTG	p.S128L	MCAT_uc003bdm.1_Missense_Mutation_p.S128L	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	128					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)				AGCGGCCAGCGATGCCACGAA	0.682													0	0	0	0.009096	0	3	5										A	43538972	G	A	43538972	3	1	40	1	0	0	0	0	1	0	0	0	9372	1059	37	1	805	1	MCAT	22	43538972	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	928951	43538972	7765594	728	10401										
SCUBE1	80274	broad.mit.edu	37	chr22	43634897	43634897	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atccaacggggcagctgcatCgcacgccagtggctgtgtcc	13	14	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:43634897C>T	uc003bdt.1	-	7	879	c.791G>A	c.(790-792)CGA>CAA	p.R264Q	SCUBE1_uc003bdu.1_Missense_Mutation_p.R294Q	NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	264	EGF-like 5 (Potential).|EGF-like 6 (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				GCAGCTGCATCGCACGCCAGT	0.607													0	0	0	0.006214	0	8	21										T	43634897	C	T	43634897	3	4	40	1	0	0	0	0	1	0	0	0	13944	884	31	1	2239	1	SCUBE1	22	43634897	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	95925	43634897	7669669	729	10402										
CELSR1	9620	broad.mit.edu	37	chr22	46932099	46932099	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gtactgtagtccacggctttCaccctgaggacgtgcgtctc	11	13	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:46932099C>T	uc003bhw.1	-	1	969	c.969G>A	c.(967-969)GTG>GTA	p.V323V		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	323	Extracellular (Potential).|Cadherin 1.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCACGGCTTTCACCCTGAGGA	0.642													0	0	0	0.001984	0	7	62										T	46932099	C	T	46932099	2	4	40	1	0	0	0	0	0	0	0	1	3221	813	29	1		1	CELSR1	22	46932099	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3297202	46932099	4372467	730	10403										
MIOX	55586	broad.mit.edu	37	chr22	50928201	50928201	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttcgacctctacaccaagtgCccggacctgccggacgtgga	11	15	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chr22:50928201C>T	uc003bll.1	+	10	888	c.774C>T	c.(772-774)TGC>TGT	p.C258C	MIOX_uc003blm.1_Missense_Mutation_p.P254S|MIOX_uc003bln.1_Missense_Mutation_p.P215S	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	258					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACACCAAGTGCCCGGACCTGC	0.642													0	0	0	0.012213	0	28	56										T	50928201	C	T	50928201	2	4	40	1	0	0	0	0	0	0	0	1	9590	747	26	2		2	MIOX	22	50928201	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	3996102	50928201	376365	731	10404										
IL3RA	3563	broad.mit.edu	37	chrX	1475113	1475113	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aagtgtttttctcgttgctaGagatattaactccacccaac	6	10	1	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:1475113G>A	uc004cps.2	+	7	966	c.617_splice	c.e7-1	p.E206_splice	IL3RA_uc011mhd.1_Splice_Site_p.E128_splice	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor							integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CTCGTTGCTAGAGATATTAAC	0.328													0	0	0	0.01441	0	52	171										A	1475113	G	A	1475113	5	1	40	1	0	0	0	0	0	0	1	0	7695	956	33	1	638	1	IL3RA	23	1475113	Splice_Site	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08		1475113	153795447	732	10405										
MXRA5	25878	broad.mit.edu	37	chrX	3239350	3239350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	caagatgatcttgatcaaggGtggtggtttctgcctgactt	12	7	3	4			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:3239350G>A	uc004crg.3	-	5	4533	c.4376C>T	c.(4375-4377)ACC>ATC	p.T1459I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1459						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTGATCAAGGGTGGTGGTTTC	0.488													0	0	0	0.00623	0	40	32										A	3239350	G	A	3239350	3	1	40	1	0	0	0	0	1	0	0	0	10003	1261	44	2	4122	2	MXRA5	23	3239350	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	1764237	3239350	152031210	733	10406										
ARHGAP6	395	broad.mit.edu	37	chrX	11272742	11272742	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	aagccacttcctgcagccggGccctctccagctctgagaga	10	16	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:11272742G>A	uc004cup.1	-	2	1547	c.674C>T	c.(673-675)GCC>GTC	p.A225V	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.A225V|ARHGAP6_uc004cum.1_Missense_Mutation_p.A22V|ARHGAP6_uc004cun.1_Missense_Mutation_p.A45V|ARHGAP6_uc010neb.1_Missense_Mutation_p.A47V|ARHGAP6_uc011mif.1_Missense_Mutation_p.A22V	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	225					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CTGCAGCCGGGCCCTCTCCAG	0.547													0	0	0	0.005443	0	27	29										A	11272742	G	A	11272742	3	1	40	1	0	0	0	0	1	0	0	0	887	1203	42	2	2420	2	ARHGAP6	23	11272742	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	8033392	11272742	143997818	734	10407										
MAGEB10	139422	broad.mit.edu	37	chrX	27840056	27840056	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atgactgtcctgggtattatCttcacaaatggcaattgtgt	9	7	2	1			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:27840056C>T	uc004dbw.2	+	3	860	c.633C>T	c.(631-633)ATC>ATT	p.I211I		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	211	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						TGGGTATTATCTTCACAAATG	0.473													0	0	0	0.003163	0	15	38										T	27840056	C	T	27840056	2	4	40	1	0	0	0	0	0	0	0	1	9173	903	32	1		1	MAGEB10	23	27840056	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	16567314	27840056	127430504	735	10408										
KDM6A	7403	broad.mit.edu	37	chrX	44894229	44894232	+	Splice_Site	DEL	AAGT	AAGT	-													0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tgcactttgtccaatgctgaAagtaagtattattaagtact							TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08			AAGT	-	AAGT	AAGT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:44894229_44894232delAAGT	uc004dge.3	+	7	994	c.619_splice	c.e7+1	p.I207_splice	KDM6A_uc010nhk.2_Splice_Site_p.I207_splice|KDM6A_uc011mkz.1_Splice_Site_p.I207_splice|KDM6A_uc011mla.1_Splice_Site_p.I207_splice|KDM6A_uc011mlb.1_Splice_Site_p.I207_splice|KDM6A_uc011mlc.1_Splice_Site	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CCAATGCTGAAAGTAAGTATTATT	0.333			D|N|F|S		renal|oesophageal SCC|MM													66	56	---	---								-	44894232	AAGT	-	44894229	8	5	40	1	0	1	0	1	0	0	1	0	8137	28	1	0	644	0	KDM6A	23	44894229	Splice_Site	DEL	AAGT	TCGA-DK-A1A3-01A-11D-A13W-08	17054173	44894229	110376331	736	10409										
ARAF	369	broad.mit.edu	37	chrX	47422403	47422403	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	gcccccctgccaatggggccGagccatcccgggcagtgggc	15	17	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:47422403G>A	uc011mlq.1	+	2	170	c.37G>A	c.(37-39)GAG>AAG	p.E13K	ARAF_uc011mln.1_RNA|ARAF_uc011mlo.1_5'UTR|ARAF_uc011mlp.1_Missense_Mutation_p.E13K|ARAF_uc004dic.1_5'Flank	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	13					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	CAATGGGGCCGAGCCATCCCG	0.627											OREG0019758	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	3										A	47422403	G	A	47422403	3	1	40	1	0	0	0	0	1	0	0	0	837	1059	37	1	39	1	ARAF	23	47422403	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	2528174	47422403	107848157	737	10410										
GNL3L	54552	broad.mit.edu	37	chrX	54569458	54569458	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	cacgaggaaggcttattacaAggagttccgtaaggtacagg	13	7	0	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:54569458A>G	uc004dth.1	+	6	516	c.377A>G	c.(376-378)AAG>AGG	p.K126R	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	126					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						GCTTATTACAAGGAGTTCCGT	0.453													0	0	0	0.00278	0	23	15										G	54569458	A	G	54569458	3	3	40	1	0	0	0	0	1	0	0	0	6538	72	3	5	395	5	GNL3L	23	54569458	Missense_Mutation	SNP	A	TCGA-DK-A1A3-01A-11D-A13W-08	7147055	54569458	100701102	738	10411										
LAS1L	81887	broad.mit.edu	37	chrX	64753613	64753613	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ccagagggagttcgttgcctGacctaaagggtcacagtcca	12	11	1	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:64753613G>A	uc004dwa.1	-	2	311	c.239C>T	c.(238-240)TCA>TTA	p.S80L	LAS1L_uc004dwc.1_Missense_Mutation_p.S80L|LAS1L_uc004dwd.1_Intron	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	80						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						TTCGTTGCCTGACCTAAAGGG	0.517													0	0	0	0.009535	0	23	17										A	64753613	G	A	64753613	3	1	40	1	0	0	0	0	1	0	0	0	8636	1294	45	1	2017	1	LAS1L	23	64753613	Missense_Mutation	SNP	G	TCGA-DK-A1A3-01A-11D-A13W-08	10184155	64753613	90516947	739	10412										
DIAPH2	1730	broad.mit.edu	37	chrX	96136711	96136711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggtttctttaaccagcaatcCggtcaggtaagtcgttctta	9	9	3	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:96136711C>T	uc004efu.3	+	5	977	c.581C>T	c.(580-582)CCG>CTG	p.P194L	DIAPH2_uc004eft.3_Missense_Mutation_p.P194L|DIAPH2_uc004efs.2_Missense_Mutation_p.P201L|RPA4_uc004efv.3_5'Flank	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	194	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						ACCAGCAATCCGGTCAGGTAA	0.343													0	0	0	0.01441	0	51	33										T	96136711	C	T	96136711	3	4	40	1	0	0	0	0	1	0	0	0	4519	652	23	2	599	2	DIAPH2	23	96136711	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	31383098	96136711	59133849	740	10413										
BTK	695	broad.mit.edu	37	chrX	100608277	100608277	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ggcaatgtgttcagcagtctCactgttagtaaatctctcat	8	9	4	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:100608277C>T	uc004ehg.2	-	18	2006	c.1813G>A	c.(1813-1815)GAG>AAG	p.E605K	BTK_uc004ehf.2_Missense_Mutation_p.E105K|BTK_uc010nnh.2_RNA|BTK_uc010nni.2_Intron|BTK_uc004ehe.2_RNA|BTK_uc010nnj.2_RNA|BTK_uc010nnk.2_RNA|BTK_uc010nnl.2_Missense_Mutation_p.E81K|BTK_uc010nnm.2_Missense_Mutation_p.E175K|BTK_uc010nnn.2_Missense_Mutation_p.E429K|BTK_uc010nno.2_Missense_Mutation_p.E639K	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	605	Protein kinase.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TCAGCAGTCTCACTGTTAGTA	0.433									Agammaglobulinemia_X-linked				0	0	0	0.01441	0	110	88										T	100608277	C	T	100608277	3	4	40	1	0	0	0	0	1	0	0	0	1557	835	29	1	174	1	BTK	23	100608277	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	4471566	100608277	54662283	741	10414										
PAK3	5063	broad.mit.edu	37	chrX	110395674	110395674	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	atacatagcagcccatccttCggtaagtgaaaaattgaaaa	7	8	0	2	rs139949467		TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:110395674C>T	uc004epa.2	+	5	539	c.512C>T	c.(511-513)TCG>TTG	p.S171L	PAK3_uc010npt.1_Missense_Mutation_p.S156L|PAK3_uc010npu.1_Missense_Mutation_p.S156L|PAK3_uc004eoy.1_5'UTR|PAK3_uc004eoz.2_Missense_Mutation_p.S156L|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.S192L|PAK3_uc010npw.1_Missense_Mutation_p.S177L	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	171	Linker.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GCCCATCCTTCGGTAAGTGAA	0.338										TSP Lung(19;0.15)			0	0	0	0.006122	0	17	57										T	110395674	C	T	110395674	3	4	40	1	0	0	0	0	1	0	0	0	11402	898	31	1	597	1	PAK3	23	110395674	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	9787397	110395674	44874886	742	10415										
TKTL1	8277	broad.mit.edu	37	chrX	153524334	153524334	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	ttccatcagggccacatgctCcacgagctccgggtaagttc	10	14	1	0			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:153524334C>T	uc004fkg.2	+	1	308	c.122C>T	c.(121-123)TCC>TTC	p.S41F	TEX28_uc004fke.2_5'Flank|TEX28_uc004fkf.2_5'Flank|TEX28_uc010nut.1_5'Flank|TKTL1_uc011mzl.1_Missense_Mutation_p.S41F|TKTL1_uc011mzm.1_Missense_Mutation_p.S41F	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	41					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCACATGCTCCACGAGCTCC	0.622													0	0	0	0.00499	0	18	53										T	153524334	C	T	153524334	3	4	40	1	0	0	0	0	1	0	0	0	15932	855	30	1	124	1	TKTL1	23	153524334	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	43128660	153524334	1746226	743	10416										
PLXNA3	55558	broad.mit.edu	37	chrX	153697282	153697282	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	tccctgagcgaggacaagctCatccgtcagcagatcgacta	10	13	2	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrX:153697282C>T	uc004flm.2	+	25	4577	c.4404C>T	c.(4402-4404)CTC>CTT	p.L1468L		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1468	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGACAAGCTCATCCGTCAGC	0.612													0	0	0	0.004878	0	34	23										T	153697282	C	T	153697282	2	4	40	1	0	0	0	0	0	0	0	1	12121	813	29	1		1	PLXNA3	23	153697282	Silent	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08	172948	153697282	1573278	744	10417										
USP9Y	8287	broad.mit.edu	37	chrY	14832567	14832567	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.471698113207547	350	5.49086226164652e-113	3.64428257479087	4.19697181852047	3.45209473841837	2.25087411695077e-26	7.31534088009e-25	254	agaattccgtagcaactcctCctccagaggaacaagggcaa	9	12	0	2			TCGA-DK-A1A3-01A-11D-A13W-08	TCGA-DK-A1A3-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2322f7cd-7d55-4a9f-b7f3-da3068089383	4744adfd-2966-4a5b-81eb-1b47e2a0d293	g.chrY:14832567C>A	uc004fst.1	+	4	1087	c.142C>A	c.(142-144)CCT>ACT	p.P48T	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	48					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AGCAACTCCTCCTCCAGAGGA	0.403													1	0	6.36457e-07	0.003954	6.53519e-07	25	28										A	14832567	C	A	14832567	3	1	40	1	0	0	0	0	1	0	0	0	17088	855	30	3	148	3	USP9Y	24	14832567	Missense_Mutation	SNP	C	TCGA-DK-A1A3-01A-11D-A13W-08		14832567	44540999	745	10418										
TAS1R1	80835	broad.mit.edu	37	chr1	6639446	6639446	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttcgtgtcctggatcgccttCttcaccacggccagcgtcta	9	15	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:6639446C>G	uc001ant.2	+	6	2328	c.2328C>G	c.(2326-2328)TTC>TTG	p.F776L	TAS1R1_uc001anu.2_Missense_Mutation_p.F522L|TAS1R1_uc001anv.2_Missense_Mutation_p.S308C|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	776	Helical; Name=6; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GGATCGCCTTCTTCACCACGG	0.577													0	0	0	0.108266	0	23	78										G	6639446	C	G	6639446	3	3	41	1	0	0	0	0	1	0	0	0	15559	913	32	1	2350	1	TAS1R1	1	6639446	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		6639446	242611175	1	10419										
DNAJC11	55735	broad.mit.edu	37	chr1	6697333	6697333	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acagtcacgtcaatcaccttCaccttctcgctcttcctgct	4	17	6	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:6697333C>A	uc001aof.2	-	14	1555	c.1449G>T	c.(1447-1449)GTG>GTT	p.V483V	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.V431V|DNAJC11_uc010nzu.1_Silent_p.V393V	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	483					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CAATCACCTTCACCTTCTCGC	0.562													1	0	3.28864e-39	0.048971	3.51189e-39	91	117										A	6697333	C	A	6697333	2	1	41	1	0	0	0	0	0	0	0	1	4630	813	29	3		3	DNAJC11	1	6697333	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	57887	6697333	242553288	2	10420										
FBXO42	54455	broad.mit.edu	37	chr1	16577222	16577222	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tttggatagtacttcacattCtgtttcttgtccatgagtcc	7	9	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:16577222C>G	uc001ayg.2	-	10	2313	c.2097G>C	c.(2095-2097)CAG>CAC	p.Q699H	FBXO42_uc001aye.3_Missense_Mutation_p.Q417H|FBXO42_uc001ayf.2_Missense_Mutation_p.Q606H	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	699										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ACTTCACATTCTGTTTCTTGT	0.428													0	0	0	0.048971	0	143	177										G	16577222	C	G	16577222	3	3	41	1	0	0	0	0	1	0	0	0	5751	912	32	1	60	1	FBXO42	1	16577222	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9879889	16577222	232673399	3	10421										
FBXO42	54455	broad.mit.edu	37	chr1	16577397	16577397	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cgtacatctgcatgggcttgCagttcatactctggtatagg	11	9	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:16577397C>T	uc001ayg.2	-	10	2138	c.1922G>A	c.(1921-1923)TGC>TAC	p.C641Y	FBXO42_uc001aye.3_Missense_Mutation_p.C359Y|FBXO42_uc001ayf.2_Missense_Mutation_p.C548Y	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	641										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		CATGGGCTTGCAGTTCATACT	0.512													0	0	0	0.048971	0	165	188										T	16577397	C	T	16577397	3	4	41	1	0	0	0	0	1	0	0	0	5751	710	25	2	235	2	FBXO42	1	16577397	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	175	16577397	232673224	4	10422										
ZBTB40	9923	broad.mit.edu	37	chr1	22828819	22828819	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agaggagggaaagaccttgtCtgttctgttactagaacaca	11	7	2	3	rs147907060	byFrequency	TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:22828819C>G	uc001bft.2	+	6	1563	c.1052C>G	c.(1051-1053)TCT>TGT	p.S351C	ZBTB40_uc001bfu.2_Missense_Mutation_p.S351C|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_5'UTR	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	351					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AAGACCTTGTCTGTTCTGTTA	0.453													0	0	0	0.069234	0	11	17										G	22828819	C	G	22828819	3	3	41	1	0	0	0	0	1	0	0	0	17539	913	32	1	1066	1	ZBTB40	1	22828819	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6251422	22828819	226421802	5	10423										
ZBTB40	9923	broad.mit.edu	37	chr1	22828866	22828866	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acctgatacagtgtgtaacaCagctgagacctattatggag	10	8	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:22828866C>T	uc001bft.2	+	6	1610	c.1099C>T	c.(1099-1101)CAG>TAG	p.Q367*	ZBTB40_uc001bfu.2_Nonsense_Mutation_p.Q367*|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_5'UTR	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	367					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GTGTGTAACACAGCTGAGACC	0.488													0	0	0	0.049695	0	20	20										T	22828866	C	T	22828866	4	4	41	1	0	0	0	0	0	1	0	0	17539	479	17	2	1113	2	ZBTB40	1	22828866	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	47	22828866	226421755	6	10424										
DHDDS	79947	broad.mit.edu	37	chr1	26772917	26772917	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtacaggccacgaagaactAcaacaagtaagttctcagat	8	9	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:26772917A>T	uc001bml.2	+	5	555	c.434A>T	c.(433-435)TAC>TTC	p.Y145F	DHDDS_uc001bmk.2_Missense_Mutation_p.Y145F|DHDDS_uc001bmm.2_Missense_Mutation_p.Y52F|DHDDS_uc001bmn.2_Intron|DHDDS_uc010ofd.1_Missense_Mutation_p.Y145F	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b	145							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		ACGAAGAACTACAACAAGTAA	0.512													0	0	0	0.048971	0	69	90										T	26772917	A	T	26772917	3	4	41	1	0	0	0	0	1	0	0	0	4478	391	14	5	448	5	DHDDS	1	26772917	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	3944051	26772917	222477704	7	10425										
EPB41	2035	broad.mit.edu	37	chr1	29438918	29438918	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcagagacacgtattgaaaaGagaattgtgatcacaggaga	11	5	2	5			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:29438918G>C	uc001brm.1	+	18	2461	c.2454G>C	c.(2452-2454)AAG>AAC	p.K818N	EPB41_uc001brg.1_Missense_Mutation_p.K595N|EPB41_uc001brh.1_Missense_Mutation_p.K542N|EPB41_uc001bri.1_Missense_Mutation_p.K729N|EPB41_uc001brj.1_Missense_Mutation_p.K555N|EPB41_uc001brl.1_Missense_Mutation_p.K785N|EPB41_uc009vtl.1_Missense_Mutation_p.K512N|EPB41_uc009vtm.1_Missense_Mutation_p.K397N|EPB41_uc009vtn.1_RNA	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	818	Carboxyl-terminal (CTD).				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GTATTGAAAAGAGAATTGTGA	0.428													0	0	0	0.045705	0	31	106										C	29438918	G	C	29438918	3	2	41	1	0	0	0	0	1	0	0	0	5151	933	33	1	2545	1	EPB41	1	29438918	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2666001	29438918	219811703	8	10426										
HMGB4	127540	broad.mit.edu	37	chr1	34329950	34329950	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggaaaaatggagatccatctCaaagcatgaaaaggccaaat	9	7	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:34329950C>G	uc001bxp.2	+	2	1901	c.158C>G	c.(157-159)TCA>TGA	p.S53*	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_5'UTR	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	53						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGATCCATCTCAAAGCATGAA	0.413													0	0	0	0.083992	0	24	115										G	34329950	C	G	34329950	4	3	41	1	0	0	0	0	0	1	0	0	7228	838	29	1	160	1	HMGB4	1	34329950	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	4891032	34329950	214920671	9	10427										
KDM4A	9682	broad.mit.edu	37	chr1	44169940	44169940	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcttcaatgagattttcacaGagaaagaggttaagcaagaa	10	5	2	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:44169940G>A	uc001cjx.2	+	22	3260	c.3094G>A	c.(3094-3096)GAG>AAG	p.E1032K	uc001cjy.2_Intron|ST3GAL3_uc009vwu.1_5'Flank|KDM4A_uc010oki.1_3'UTR	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	1032					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						GATTTTCACAGAGAAAGAGGT	0.438													0	0	0	0.048971	0	144	172										A	44169940	G	A	44169940	3	1	41	1	0	0	0	0	1	0	0	0	8128	943	33	1	3176	1	KDM4A	1	44169940	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	9839990	44169940	205080681	10	10428										
ELAVL4	1996	broad.mit.edu	37	chr1	50610766	50610766	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gacagcaaaaccaacctcatCgtcaactatttaccccagaa	4	14	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:50610766C>T	uc001csb.2	+	2	415	c.147C>T	c.(145-147)ATC>ATT	p.I49I	ELAVL4_uc001cry.3_Silent_p.I52I|ELAVL4_uc001crz.3_Silent_p.I49I|ELAVL4_uc001csa.3_Silent_p.I66I|ELAVL4_uc001csc.3_Silent_p.I49I|ELAVL4_uc009vyu.2_Silent_p.I54I|ELAVL4_uc010omz.1_Silent_p.I54I	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	49	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						CCAACCTCATCGTCAACTATT	0.448													0	0	0	0.038147	0	8	31										T	50610766	C	T	50610766	2	4	41	1	0	0	0	0	0	0	0	1	5052	874	31	1		1	ELAVL4	1	50610766	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6440826	50610766	198639855	11	10429										
ORC1L	4998	broad.mit.edu	37	chr1	52863536	52863536	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttaggaggaggatcagagtCtagaaagaatttggtggaaa	14	3	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:52863536C>T	uc001ctt.2	-	4	443	c.224_splice	c.e4-1	p.D75_splice	ORC1L_uc010oni.1_Splice_Site_p.D75_splice|ORC1L_uc001ctu.2_Splice_Site_p.D75_splice|ORC1L_uc009vzd.2_Splice_Site	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1						cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						GGATCAGAGTCTAGAAAGAAT	0.363													0	0	0	0.064281	0	34	98										T	52863536	C	T	52863536	5	4	41	1	0	0	0	0	0	0	1	0	11261	927	32	1	2418	1	ORC1L	1	52863536	Splice_Site	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2252770	52863536	196387085	12	10430										
GLIS1	148979	broad.mit.edu	37	chr1	54060249	54060249	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gggccccccagatctcccgtCagaggggggctccggagtcc	15	16	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:54060249C>T	uc001cvr.1	-	3	894	c.327G>A	c.(325-327)CTG>CTA	p.L109L		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	109					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GATCTCCCGTCAGAGGGGGGC	0.657													0	0	0	0.055883	0	19	56										T	54060249	C	T	54060249	2	4	41	1	0	0	0	0	0	0	0	1	6445	813	29	1		1	GLIS1	1	54060249	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1196713	54060249	195190372	13	10431										
PCSK9	255738	broad.mit.edu	37	chr1	55523842	55523842	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaccagcgggtactgaccccCaacctggtggccgccctgcc	12	18	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:55523842C>G	uc001cyf.1	+	8	1605	c.1314C>G	c.(1312-1314)CCC>CCG	p.P438P	PCSK9_uc010oom.1_Intron	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	438					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TACTGACCCCCAACCTGGTGG	0.627													0	0	0	0.0333	0	15	71										G	55523842	C	G	55523842	2	3	41	1	0	0	0	0	0	0	0	1	11606	581	21	4		4	PCSK9	1	55523842	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1463593	55523842	193726779	14	10432										
ABCA4	24	broad.mit.edu	37	chr1	94476481	94476481	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aacggatttgcagagtgctcCtcacctgggcatcaacagga	11	11	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:94476481C>T	uc001dqh.2	-	40	5693	c.5589G>A	c.(5587-5589)GAG>GAA	p.E1863E	ABCA4_uc001dqi.1_5'UTR|ABCA4_uc009wdp.1_Silent_p.E131E	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1863					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CAGAGTGCTCCTCACCTGGGC	0.592													0	0	0	0.038147	0	8	30										T	94476481	C	T	94476481	2	4	41	1	0	0	0	0	0	0	0	1	34	680	24	2		2	ABCA4	1	94476481	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	38952639	94476481	154774140	15	10433										
ARHGAP29	9411	broad.mit.edu	37	chr1	94674863	94674863	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaagaaaacacttcctggaaGagatcgtttttgttttcttc	8	7	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:94674863G>A	uc001dqj.3	-	4	753	c.384C>T	c.(382-384)CTC>CTT	p.L128L	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Silent_p.L128L	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	128					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CTTCCTGGAAGAGATCGTTTT	0.323													0	0	0	0.024245	0	15	31										A	94674863	G	A	94674863	2	1	41	1	0	0	0	0	0	0	0	1	878	929	33	1		1	ARHGAP29	1	94674863	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	198382	94674863	154575758	16	10434										
AGL	178	broad.mit.edu	37	chr1	100379088	100379088	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tatgtcatttttcaggaaagGctataaaggtctcatatgat	8	5	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:100379088G>C	uc001dsi.1	+	30	4355	c.3955G>C	c.(3955-3957)GCT>CCT	p.A1319P	AGL_uc001dsj.1_Missense_Mutation_p.A1319P|AGL_uc001dsk.1_Missense_Mutation_p.A1319P|AGL_uc001dsl.1_Missense_Mutation_p.A1319P|AGL_uc001dsm.1_Missense_Mutation_p.A1303P|AGL_uc001dsn.1_Missense_Mutation_p.A1302P	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1319	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTCAGGAAAGGCTATAAAGGT	0.294													0	0	0	0.069234	0	8	25										C	100379088	G	C	100379088	3	2	41	1	0	0	0	0	1	0	0	0	384	1203	42	4	4138	4	AGL	1	100379088	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5704225	100379088	148871533	17	10435										
AMY2A	279	broad.mit.edu	37	chr1	104160582	104160582	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtttaatttgtaggtctctCcaccaaatgaaaatgttgca	7	7	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:104160582C>T	uc001dut.2	+	2	239	c.175C>T	c.(175-177)CCA>TCA	p.P59S	AMY2A_uc010ouq.1_Missense_Mutation_p.P59S	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	59					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	GTAGGTCTCTCCACCAAATGA	0.333													0	0	0	0.058154	0	10	45										T	104160582	C	T	104160582	3	4	41	1	0	0	0	0	1	0	0	0	594	855	30	1	181	1	AMY2A	1	104160582	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3781494	104160582	145090039	18	10436										
NUDT17	200035	broad.mit.edu	37	chr1	145586854	145586854	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcaaacttggttccagtgctGactctctctttgtcctctgc	8	13	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:145586854G>A	uc001eoe.2	-	7	842	c.834C>T	c.(832-834)GTC>GTT	p.V278V	NBPF10_uc001emp.3_Intron	NM_001012758	NP_001012776	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety	278							hydrolase activity|metal ion binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCCAGTGCTGACTCTCTCTT	0.547													0	0	0	0.048971	0	294	465										A	145586854	G	A	145586854	2	1	41	1	0	0	0	0	0	0	0	1	10734	1277	45	1		1	NUDT17	1	145586854	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	41426272	145586854	103663767	19	10437										
SV2A	9900	broad.mit.edu	37	chr1	149885327	149885327	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttcttggccgcatgctttttGacttccttagcaatgtcttt	7	10	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:149885327G>T	uc001etg.2	-	2	557	c.66C>A	c.(64-66)GTC>GTA	p.V22V	SV2A_uc001eth.2_Silent_p.V22V	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	22	Cytoplasmic (Potential).|Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CATGCTTTTTGACTTCCTTAG	0.552													1	0	8.39805e-80	0.048971	9.0628e-80	130	181										T	149885327	G	T	149885327	2	4	41	1	0	0	0	0	0	0	0	1	15414	1277	45	3		3	SV2A	1	149885327	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4298473	149885327	99365294	20	10438										
SCNM1	79005	broad.mit.edu	37	chr1	151138954	151138954	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctactccctgcagaaaagaaGagtcggggacctcctagcca	10	13	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:151138954G>A	uc001ewz.2	+	2	171	c.59G>A	c.(58-60)AGA>AAA	p.R20K	LYSMD1_uc001ewy.2_5'Flank|LYSMD1_uc010pcr.1_5'Flank|SCNM1_uc010pcs.1_Missense_Mutation_p.R20K|SCNM1_uc009wmn.2_RNA	NM_024041	NP_076946	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	20	Bipartite nuclear localization signal (Potential).				mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGAAAAGAAGAGTCGGGGAC	0.527													0	0	0	0.09319	0	9	61										A	151138954	G	A	151138954	3	1	41	1	0	0	0	0	1	0	0	0	13926	942	33	1	65	1	SCNM1	1	151138954	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1253627	151138954	98111667	21	10439										
HRNR	388697	broad.mit.edu	37	chr1	152188121	152188121	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagaggactgtcctgagcgaGactctcggtgacctaagcca	12	12	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:152188121G>T	uc001ezt.1	-	3	6060	c.5984C>A	c.(5983-5985)TCT>TAT	p.S1995Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1995	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGAGCGAGACTCTCGGTG	0.572													1	0	5.43694e-19	0.080422	5.74601e-19	22	404										T	152188121	G	T	152188121	3	4	41	1	0	0	0	0	1	0	0	0	7359	942	33	3	2572	3	HRNR	1	152188121	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1049167	152188121	97062500	22	10440										
GATAD2B	57459	broad.mit.edu	37	chr1	153800712	153800712	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tttcagacgttccatggcctCatgcccctccattttgagtc	7	14	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:153800712C>T	uc001fdb.3	-	2	356	c.112G>A	c.(112-114)GAG>AAG	p.E38K		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	38						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCCATGGCCTCATGCCCCTCC	0.502													0	0	0	0.048971	0	200	330										T	153800712	C	T	153800712	3	4	41	1	0	0	0	0	1	0	0	0	6261	835	29	1	1709	1	GATAD2B	1	153800712	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1612591	153800712	95449909	23	10441										
DCST1	149095	broad.mit.edu	37	chr1	155020372	155020372	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caggcttttggctaccgactCcggagggtcatcgcagcctt	12	13	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:155020372C>G	uc001fgn.1	+	15	1818	c.1722C>G	c.(1720-1722)CTC>CTG	p.L574L	DCST1_uc010pes.1_Silent_p.L549L|uc001fgo.2_Intron	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	574	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GCTACCGACTCCGGAGGGTCA	0.607													0	0	0	0.047766	0	8	76										G	155020372	C	G	155020372	2	3	41	1	0	0	0	0	0	0	0	1	4302	842	30	1		1	DCST1	1	155020372	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1219660	155020372	94230249	24	10442										
TRIM46	80128	broad.mit.edu	37	chr1	155152267	155152267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aggccccacccgctggcagcGgcgggaggaggtgaggggca	20	12	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:155152267G>A	uc001fhs.1	+	8	1528	c.1445G>A	c.(1444-1446)CGG>CAG	p.R482Q	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.R482Q|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.R356Q|TRIM46_uc001fhu.1_Missense_Mutation_p.R459Q|TRIM46_uc009wpg.1_Missense_Mutation_p.R469Q|TRIM46_uc001fhv.3_Missense_Mutation_p.R469Q|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	482	Fibronectin type-III.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGCTGGCAGCGGCGGGAGGAG	0.687													0	0	0	0.038147	0	6	18										A	155152267	G	A	155152267	3	1	41	1	0	0	0	0	1	0	0	0	16518	1116	39	2	1475	2	TRIM46	1	155152267	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	131895	155152267	94098354	25	10443										
IQGAP3	128239	broad.mit.edu	37	chr1	156497752	156497752	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgtcccctcacctgatagtGaagctgaaatcgctccatgt	8	13	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:156497752G>A	uc001fpf.2	-	37	4849	c.4774C>T	c.(4774-4776)CAC>TAC	p.H1592Y		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1592					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACCTGATAGTGAAGCTGAAAT	0.527													0	0	0	0.048971	0	50	51										A	156497752	G	A	156497752	3	1	41	1	0	0	0	0	1	0	0	0	7816	1290	45	1	129	1	IQGAP3	1	156497752	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1345485	156497752	92752869	26	10444										
DDR2	4921	broad.mit.edu	37	chr1	162725538	162725538	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttatctgaatgattctgtctAtgatggagctgttggataca	10	5	3	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:162725538A>G	uc001gcf.2	+	8	1115	c.650A>G	c.(649-651)TAT>TGT	p.Y217C	DDR2_uc001gcg.2_Missense_Mutation_p.Y217C	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	217	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GATTCTGTCTATGATGGAGCT	0.403													0	0	0	0.080422	0	35	28										G	162725538	A	G	162725538	3	3	41	1	0	0	0	0	1	0	0	0	4337	449	16	5	668	5	DDR2	1	162725538	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	6227786	162725538	86525083	27	10445										
TPR	7175	broad.mit.edu	37	chr1	186304579	186304579	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttcatattgggactttagcGcagtaatgcgaacatccaat	8	9	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:186304579G>A	uc001grv.2	-	34	5099	c.4802C>T	c.(4801-4803)GCG>GTG	p.A1601V		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1601	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GGACTTTAGCGCAGTAATGCG	0.423			T	NTRK1	papillary thyroid								0	0	0	0.021553	0	6	31										A	186304579	G	A	186304579	3	1	41	1	0	0	0	0	1	0	0	0	16413	1087	38	2	2361	2	TPR	1	186304579	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	23579041	186304579	62946042	28	10446										
SYT2	127833	broad.mit.edu	37	chr1	202571539	202571539	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtttcattgaaggcagggttCagtgtcttccgatggacttt	12	7	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:202571539C>T	uc001gye.2	-	5	793	c.600G>A	c.(598-600)CTG>CTA	p.L200L	SYT2_uc010pqb.1_Silent_p.L200L|SYT2_uc009xaf.2_Silent_p.L30L	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	200	Phospholipid binding (By similarity).|C2 1.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	AGGCAGGGTTCAGTGTCTTCC	0.517													0	0	0	0.048971	0	159	79										T	202571539	C	T	202571539	2	4	41	1	0	0	0	0	0	0	0	1	15471	813	29	1		1	SYT2	1	202571539	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	16266960	202571539	46679082	29	10447										
CENPF	1063	broad.mit.edu	37	chr1	214794110	214794110	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaagaccccaagtcatctttCatctaattctcaaagaactc	4	12	5	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:214794110C>T	uc001hkm.2	+	6	860	c.686C>T	c.(685-687)TCA>TTA	p.S229L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	229	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGTCATCTTTCATCTAATTCT	0.458													0	0	0	0.048971	0	67	36										T	214794110	C	T	214794110	3	4	41	1	0	0	0	0	1	0	0	0	3231	838	29	1	704	1	CENPF	1	214794110	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	12222571	214794110	34456511	30	10448										
HHIPL2	79802	broad.mit.edu	37	chr1	222713588	222713588	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cggggtgggcccctggctcaGaaacaaatggattgtccgag	15	10	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:222713588G>T	uc001hnh.1	-	4	1272	c.1214C>A	c.(1213-1215)TCT>TAT	p.S405Y		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	405					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CCCTGGCTCAGAAACAAATGG	0.587													1	0	1.00246e-47	0.048971	1.07332e-47	77	35										T	222713588	G	T	222713588	3	4	41	1	0	0	0	0	1	0	0	0	7094	942	33	3	984	3	HHIPL2	1	222713588	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	7919478	222713588	26537033	31	10449										
ZP4	57829	broad.mit.edu	37	chr1	238048519	238048519	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttcacaaagctgaaggtgaaGatgctgaagcgctggtggtg	15	6	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:238048519G>A	uc001hym.2	-	9	1257	c.1257C>T	c.(1255-1257)ATC>ATT	p.I419I	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	419	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGAAGGTGAAGATGCTGAAGC	0.547													0	0	0	0.11126	0	42	18										A	238048519	G	A	238048519	2	1	41	1	0	0	0	0	0	0	0	1	18215	932	33	1		1	ZP4	1	238048519	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	15334931	238048519	11202102	32	10450										
ZNF670	93474	broad.mit.edu	37	chr1	247200919	247200919	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccttacatccataaggtttCactccagtgtgagttctttc	6	11	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:247200919C>A	uc001icd.1	-	4	1173	c.1002G>T	c.(1000-1002)GTG>GTT	p.V334V	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			CATAAGGTTTCACTCCAGTGT	0.408													1	0	1.79992e-35	0.048971	1.9171e-35	93	126										A	247200919	C	A	247200919	2	1	41	1	0	0	0	0	0	0	0	1	18074	813	29	3		3	ZNF670	1	247200919	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9152400	247200919	2049702	33	10451										
OR2G6	391211	broad.mit.edu	37	chr1	248685406	248685406	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggagcatggctcagcggcctCatcacctccctaattcagtg	10	14	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr1:248685406C>T	uc001ien.1	+	1	459	c.459C>T	c.(457-459)CTC>CTT	p.L153L		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCAGCGGCCTCATCACCTCCC	0.572													0	0	0	0.076483	0	23	16										T	248685406	C	T	248685406	2	4	41	1	0	0	0	0	0	0	0	1	11000	813	29	1		1	OR2G6	1	248685406	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1484487	248685406	565215	34	10452										
GREB1	9687	broad.mit.edu	37	chr2	11773124	11773124	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gacatctggcctttcattgtGatctctgatgactcctgcgt	9	11	3	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:11773124G>A	uc002rbk.1	+	28	5226	c.4926G>A	c.(4924-4926)GTG>GTA	p.V1642V	GREB1_uc002rbp.1_Silent_p.V640V	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1642						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CTTTCATTGTGATCTCTGATG	0.562													0	0	0	0.048971	0	47	74										A	11773124	G	A	11773124	2	1	41	1	0	0	0	0	0	0	0	1	6760	1277	45	1		1	GREB1	2	11773124	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		11773124	231426249	35	10453										
RAD51AP2	729475	broad.mit.edu	37	chr2	17698327	17698327	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gattgttcttcatatgcattGatgacttttgcacagtggta	9	6	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:17698327G>C	uc002rcl.1	-	1	1380	c.1356C>G	c.(1354-1356)ATC>ATG	p.I452M	RAD51AP2_uc010exn.1_Missense_Mutation_p.I443M	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	452										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CATATGCATTGATGACTTTTG	0.313													0	0	0	0.099896	0	27	41										C	17698327	G	C	17698327	3	2	41	1	0	0	0	0	1	0	0	0	12987	1280	45	1	2135	1	RAD51AP2	2	17698327	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5925203	17698327	225501046	36	10454										
PUM2	23369	broad.mit.edu	37	chr2	20511319	20511319	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccatttattttagaatcatCatcatctccttgtttaagat	4	8	4	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:20511319C>A	uc002rds.1	-	4	477	c.454G>T	c.(454-456)GAT>TAT	p.D152Y	PUM2_uc002rdt.1_Missense_Mutation_p.D152Y|PUM2_uc002rdr.2_Missense_Mutation_p.D91Y|PUM2_uc010yjy.1_Missense_Mutation_p.D152Y|PUM2_uc002rdu.1_Missense_Mutation_p.D152Y|PUM2_uc010yjz.1_Missense_Mutation_p.D91Y	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	152	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTAGAATCATCATCATCTCCT	0.378													1	0	6.00712e-18	0.050027	6.33225e-18	33	65										A	20511319	C	A	20511319	3	1	41	1	0	0	0	0	1	0	0	0	12826	826	29	3	2808	3	PUM2	2	20511319	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2812992	20511319	222688054	37	10455										
CRIM1	51232	broad.mit.edu	37	chr2	36744610	36744610	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acagcggacgggtgctgtgtGagacagaggtgtgcccaccg	17	10	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:36744610G>C	uc002rpd.2	+	12	2170	c.2131G>C	c.(2131-2133)GAG>CAG	p.E711Q		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	711	VWFC 4.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GGTGCTGTGTGAGACAGAGGT	0.582													0	0	0	0.020292	0	9	95										C	36744610	G	C	36744610	3	2	41	1	0	0	0	0	1	0	0	0	3873	1291	45	1	2177	1	CRIM1	2	36744610	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	16233291	36744610	206454763	38	10456										
HAAO	23498	broad.mit.edu	37	chr2	42995022	42995022	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gctgccacagccacacgtccAcattctgtctcaggccttcg	8	17	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:42995022A>T	uc002rst.3	-	8	752	c.677T>A	c.(676-678)GTG>GAG	p.V226E		NM_012205	NP_036337	P46952	3HAO_HUMAN	3-hydroxyanthranilate 3,4-dioxygenase	226	Domain B (By similarity).				neuron homeostasis|pyridine nucleotide biosynthetic process|quinolinate biosynthetic process|response to cadmium ion|response to zinc ion|tryptophan catabolic process	cytosol|soluble fraction	3-hydroxyanthranilate 3,4-dioxygenase activity|electron carrier activity|ferrous iron binding			ovary(1)	1						CCACACGTCCACATTCTGTCT	0.632													0	0	0	0.048971	0	50	58										T	42995022	A	T	42995022	3	4	41	1	0	0	0	0	1	0	0	0	6937	159	6	5	195	5	HAAO	2	42995022	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	6250412	42995022	200204351	39	10457										
PLEKHH2	130271	broad.mit.edu	37	chr2	43939476	43939476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acaagctgccaacccactttCcctgcagcctgagggcaaac	8	16	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:43939476C>T	uc010yny.1	+	15	2497	c.2414C>T	c.(2413-2415)TCC>TTC	p.S805F	PLEKHH2_uc002rte.3_3'UTR|PLEKHH2_uc002rtf.3_Missense_Mutation_p.S804F	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	805						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AACCCACTTTCCCTGCAGCCT	0.478													0	0	0	0.048971	0	51	49										T	43939476	C	T	43939476	3	4	41	1	0	0	0	0	1	0	0	0	12077	855	30	1	2468	1	PLEKHH2	2	43939476	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	944454	43939476	199259897	40	10458										
EPAS1	2034	broad.mit.edu	37	chr2	46608758	46608758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgcaaagggttttggggctcGaggcccagacgtgctgagtc	16	9	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:46608758G>A	uc002ruv.2	+	13	2557	c.2069G>A	c.(2068-2070)CGA>CAA	p.R690Q	EPAS1_uc002ruw.2_Missense_Mutation_p.R156Q	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	690					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			TTTGGGGCTCGAGGCCCAGAC	0.597													0	0	0	0.076483	0	24	62										A	46608758	G	A	46608758	3	1	41	1	0	0	0	0	1	0	0	0	5150	1058	37	1	2119	1	EPAS1	2	46608758	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2669282	46608758	196590615	41	10459										
RPS27A	6233	broad.mit.edu	37	chr2	55461976	55461976	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccattaacaggagtctactCttcatcttgtgttgagactt	7	9	4	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:55461976C>G	uc010yow.1	+	5	396	c.199C>G	c.(199-201)CTT>GTT	p.L67V	C2orf63_uc002ryh.2_5'Flank|C2orf63_uc002ryi.2_5'Flank|C2orf63_uc002ryj.2_5'Flank|RPS27A_uc002ryk.2_Missense_Mutation_p.L67V|RPS27A_uc002ryl.2_RNA|RPS27A_uc002rym.2_RNA	NM_001135592	NP_001129064	P62979	RS27A_HUMAN	ubiquitin and ribosomal protein S27a precursor	67	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	metal ion binding|structural constituent of ribosome			ovary(1)	1						GGAGTCTACTCTTCATCTTGT	0.398													0	0	0	0.043863	0	17	81										G	55461976	C	G	55461976	3	3	41	1	0	0	0	0	1	0	0	0	13639	913	32	1	213	1	RPS27A	2	55461976	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	8853218	55461976	187737397	42	10460										
C1D	10438	broad.mit.edu	37	chr2	68273488	68273488	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acacataccccaaaacattgAatttaatgtgtatgcagaaa	5	8	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:68273488A>T	uc002sea.3	-	3	275	c.193T>A	c.(193-195)TCA>ACA	p.S65T	C1D_uc002seb.2_Missense_Mutation_p.S65T|C1D_uc002sec.2_Missense_Mutation_p.S65T|C1D_uc010fdc.2_Missense_Mutation_p.S65T	NM_173177	NP_775269	Q13901	C1D_HUMAN	nuclear DNA-binding protein	65	Required for transcriptional repression (By similarity).|Interaction with NR1D1 (By similarity).				apoptosis|maturation of 5.8S rRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear exosome (RNase complex)|nucleolus	DNA binding|RNA binding				0						CAAAACATTGAATTTAATGTG	0.224													0	0	0	0.105934	0	13	25										T	68273488	A	T	68273488	3	4	41	1	0	0	0	0	1	0	0	0	1951	246	9	5	244	5	C1D	2	68273488	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	12811512	68273488	174925885	43	10461										
ARID5A	10865	broad.mit.edu	37	chr2	97216890	97216890	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acccagcaccacttcccagcCaggagccccccaggaacagc	8	20	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:97216890C>T	uc002swe.2	+	7	725	c.625C>T	c.(625-627)CAG>TAG	p.Q209*	ARID5A_uc010yuq.1_Nonsense_Mutation_p.Q157*|ARID5A_uc002swf.2_Nonsense_Mutation_p.Q45*|ARID5A_uc002swg.2_Nonsense_Mutation_p.Q157*	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	209					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						ACTTCCCAGCCAGGAGCCCCC	0.597													0	0	0	0.048971	0	73	117										T	97216890	C	T	97216890	4	4	41	1	0	0	0	0	0	1	0	0	921	595	21	2	651	2	ARID5A	2	97216890	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	28943402	97216890	145982483	44	10462										
MARCO	8685	broad.mit.edu	37	chr2	119750864	119750864	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccaaaggaagggccctgtacAaagtgggagctggtaagtga	15	7	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:119750864A>G	uc002tln.1	+	16	1549	c.1417A>G	c.(1417-1419)AAA>GAA	p.K473E	MARCO_uc010yyf.1_Missense_Mutation_p.K395E	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	473	SRCR.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GGCCCTGTACAAAGTGGGAGC	0.557													0	0	0	0.048971	0	53	78										G	119750864	A	G	119750864	3	3	41	1	0	0	0	0	1	0	0	0	9311	131	5	5	1479	5	MARCO	2	119750864	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	22533974	119750864	123448509	45	10463										
GLI2	2736	broad.mit.edu	37	chr2	121732608	121732608	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atgactgtaagcaggaggctGaggtggtcatctatgagacc	14	7	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:121732608G>C	uc010flp.2	+	8	1321	c.1291G>C	c.(1291-1293)GAG>CAG	p.E431Q	GLI2_uc002tmq.1_Missense_Mutation_p.E103Q|GLI2_uc002tmr.1_Missense_Mutation_p.E86Q|GLI2_uc002tmt.3_Missense_Mutation_p.E103Q|GLI2_uc002tmu.3_Missense_Mutation_p.E86Q|GLI2_uc010flo.1_Missense_Mutation_p.E289Q|GLI2_uc002tmw.1_Missense_Mutation_p.E414Q	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	431					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCAGGAGGCTGAGGTGGTCAT	0.577													0	0	0	0.069456	0	34	59										C	121732608	G	C	121732608	3	2	41	1	0	0	0	0	1	0	0	0	6438	1291	45	1	1321	1	GLI2	2	121732608	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1981744	121732608	121466765	46	10464										
MKI67IP	84365	broad.mit.edu	37	chr2	122486097	122486097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	attagtttttgaaatactttCcgttttctgtaaaatcttta	4	5	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:122486097C>T	uc002tnk.2	-	5	657	c.580G>A	c.(580-582)GAA>AAA	p.E194K	uc002tnj.1_RNA	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	194					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						GAAATACTTTCCGTTTTCTGT	0.274													0	0	0	0.0333	0	14	58										T	122486097	C	T	122486097	3	4	41	1	0	0	0	0	1	0	0	0	9599	864	30	1	313	1	MKI67IP	2	122486097	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	753489	122486097	120713276	47	10465										
PRPF40A	55660	broad.mit.edu	37	chr2	153519641	153519641	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcgtttcatcttccgagcctCttctttttctctttcacgtt	4	13	6	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:153519641C>T	uc002tyh.3	-	20	2156	c.2134G>A	c.(2134-2136)GAG>AAG	p.E712K	PRPF40A_uc002tyg.3_Missense_Mutation_p.E168K|PRPF40A_uc010zcd.1_Missense_Mutation_p.E663K	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	739					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TTCCGAGCCTCTTCTTTTTCT	0.348													0	0	0	0.058154	0	10	16										T	153519641	C	T	153519641	3	4	41	1	0	0	0	0	1	0	0	0	12571	922	32	1	686	1	PRPF40A	2	153519641	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	31033544	153519641	89679732	48	10466										
LRP2	4036	broad.mit.edu	37	chr2	170127522	170127522	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gacaaagaaagaaggattccCcgaaactggaaccatgacat	9	9	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:170127522C>T	uc002ues.2	-	16	2425	c.2212G>A	c.(2212-2214)GGG>AGG	p.G738R	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	738	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GAAGGATTCCCCGAAACTGGA	0.408													0	0	0	0.02938	0	6	27										T	170127522	C	T	170127522	3	4	41	1	0	0	0	0	1	0	0	0	8956	623	22	2	12011	2	LRP2	2	170127522	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	16607881	170127522	73071851	49	10467										
GPR155	151556	broad.mit.edu	37	chr2	175335161	175335161	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtgttgcaaagatagccactCctggtgctacaggaaataca	10	9	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:175335161C>G	uc002uit.2	-	5	1374	c.983G>C	c.(982-984)GGA>GCA	p.G328A	GPR155_uc002uiu.2_Missense_Mutation_p.G328A|GPR155_uc002uiv.2_Missense_Mutation_p.G328A|GPR155_uc010fqs.2_Missense_Mutation_p.G328A	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	328	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						GATAGCCACTCCTGGTGCTAC	0.358													0	0	0	0.028581	0	15	21										G	175335161	C	G	175335161	3	3	41	1	0	0	0	0	1	0	0	0	6660	855	30	1	1681	1	GPR155	2	175335161	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	5207639	175335161	67864212	50	10468										
TTC30A	92104	broad.mit.edu	37	chr2	178483399	178483399	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tagcgcggtaaactccccgtCggggatctgcgcgccgctca	13	15	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:178483399C>T	uc002ulo.2	-	1	296	c.31G>A	c.(31-33)GAC>AAC	p.D11N		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	11	TPR 1.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			AACTCCCCGTCGGGGATCTGC	0.667													0	0	0	0.004672	0	3	8										T	178483399	C	T	178483399	3	4	41	1	0	0	0	0	1	0	0	0	16695	884	31	1	1970	1	TTC30A	2	178483399	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3148238	178483399	64715974	51	10469										
DNAH7	56171	broad.mit.edu	37	chr2	196605504	196605504	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	actaaccacaggcactgtatCataaagaattttgggatgcg	9	8	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:196605504C>G	uc002utj.3	-	64	11955	c.11854G>C	c.(11854-11856)GAT>CAT	p.D3952H	DNAH7_uc002uti.3_Missense_Mutation_p.D435H	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3952					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GGCACTGTATCATAAAGAATT	0.284													0	0	0	0.043863	0	18	55										G	196605504	C	G	196605504	3	3	41	1	0	0	0	0	1	0	0	0	4606	826	29	1	228	1	DNAH7	2	196605504	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	18122105	196605504	46593869	52	10470										
INO80D	54891	broad.mit.edu	37	chr2	206872011	206872011	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caaaatattgactataccttCaaaaaaatcaaaatcttgta	2	7	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:206872011C>T	uc002vaz.3	-	10	2320	c.1915G>A	c.(1915-1917)GAA>AAA	p.E639K		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	639					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						ACTATACCTTCAAAAAAATCA	0.348													0	0	0	0.043863	0	19	41										T	206872011	C	T	206872011	3	4	41	1	0	0	0	0	1	0	0	0	7749	835	29	1	1176	1	INO80D	2	206872011	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	10266507	206872011	36327362	53	10471										
CYP27A1	1593	broad.mit.edu	37	chr2	219679423	219679423	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtgccctttggctatggggtCcgggcctgcctgggccgcag	17	13	0	0	rs138596741		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:219679423C>G	uc002viz.3	+	8	1853	c.1419C>G	c.(1417-1419)GTC>GTG	p.V473V		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	473					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	GCTATGGGGTCCGGGCCTGCC	0.637													0	0	0	0.020292	0	13	32										G	219679423	C	G	219679423	2	3	41	1	0	0	0	0	0	0	0	1	4158	842	30	1		1	CYP27A1	2	219679423	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	12807412	219679423	23519950	54	10472										
INHA	3623	broad.mit.edu	37	chr2	220439960	220439960	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtagcactgaacatctccttCcaggagctgggctgggaacg	13	11	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:220439960C>T	uc002vmk.1	+	2	957	c.813C>T	c.(811-813)TTC>TTT	p.F271F		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	271					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		ACATCTCCTTCCAGGAGCTGG	0.607													0	0	0	0.034045	0	27	66										T	220439960	C	T	220439960	2	4	41	1	0	0	0	0	0	0	0	1	7740	854	30	1		1	INHA	2	220439960	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	760537	220439960	22759413	55	10473										
STK11IP	114790	broad.mit.edu	37	chr2	220466159	220466159	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgcagaaaacactttcactCaaggttctgggtgtggggaa	12	8	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:220466159C>G	uc002vml.2	+	3	340	c.297C>G	c.(295-297)CTC>CTG	p.L99L	STK11IP_uc010zlj.1_Silent_p.L88L|STK11IP_uc010zlk.1_Silent_p.L88L|STK11IP_uc010zll.1_Silent_p.L88L|STK11IP_uc002vmm.1_Silent_p.L88L	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	99					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACTTTCACTCAAGGTTCTGG	0.542													0	0	0	0.024245	0	14	31										G	220466159	C	G	220466159	2	3	41	1	0	0	0	0	0	0	0	1	15287	813	29	1		1	STK11IP	2	220466159	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	26199	220466159	22733214	56	10474										
NEU2	4759	broad.mit.edu	37	chr2	233899698	233899698	+	Frame_Shift_Del	DEL	T	T	-													0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtctgtacgaagccaatgaTtacgaggagattgtctttct							TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr2:233899698delT	uc010zmn.1	+	2	1074	c.1074delT	c.(1072-1074)GATfs	p.D358fs		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	358							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		AAGCCAATGATTACGAGGAGA	0.577																		92	285	---	---								-	233899698	T	-	233899698	7	5	41	1	0	1	0	1	0	0	0	0	10342	1490	52	0	1080	0	NEU2	2	233899698	Frame_Shift_Del	DEL	T	TCGA-DK-A1A5-01A-11D-A13W-08	13433539	233899698	9299675	57	10475										
EDEM1	9695	broad.mit.edu	37	chr3	5243458	5243458	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggtcctgggaagcctcctttCtgctcacagaataataactg	9	11	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:5243458C>T	uc003bqi.2	+	4	839	c.707C>T	c.(706-708)TCT>TTT	p.S236F	EDEM1_uc011asz.1_Missense_Mutation_p.S14F|EDEM1_uc003bqh.2_Missense_Mutation_p.S236F	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	236	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AGCCTCCTTTCTGCTCACAGA	0.408													0	0	0	0.108266	0	27	106										T	5243458	C	T	5243458	3	4	41	1	0	0	0	0	1	0	0	0	4911	913	32	1	721	1	EDEM1	3	5243458	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		5243458	192778972	58	10476										
IL17RC	84818	broad.mit.edu	37	chr3	9965627	9965627	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atctggttctgaatgtctctGaggagcagcacttcggcctc	11	11	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:9965627G>T	uc003bua.2	+	8	1134	c.898G>T	c.(898-900)GAG>TAG	p.E300*	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_RNA|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Nonsense_Mutation_p.E204*|IL17RC_uc003btz.2_Nonsense_Mutation_p.E229*|IL17RC_uc011atp.1_Nonsense_Mutation_p.E85*|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Nonsense_Mutation_p.E214*|IL17RC_uc010hct.2_Nonsense_Mutation_p.E229*|IL17RC_uc010hcu.2_Nonsense_Mutation_p.E229*|IL17RC_uc010hcv.2_Nonsense_Mutation_p.E214*|IL17RC_uc011atq.1_Nonsense_Mutation_p.E214*|IL17RC_uc003buc.2_5'UTR	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	300	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GAATGTCTCTGAGGAGCAGCA	0.592													1	0	4.81362e-53	0.048971	5.16738e-53	96	79										T	9965627	G	T	9965627	4	4	41	1	0	0	0	0	0	1	0	0	7641	1291	45	3	928	3	IL17RC	3	9965627	Nonsense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4722169	9965627	188056803	59	10477										
FANCD2	2177	broad.mit.edu	37	chr3	10078013	10078013	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttgagaagttgccagaatatTtttttgaaaagtaagtggcg	11	3	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:10078013T>G	uc003buw.2	+	7	559	c.481T>G	c.(481-483)TTT>GTT	p.F161V	FANCD2_uc003bux.1_Missense_Mutation_p.F161V|FANCD2_uc003buy.1_Missense_Mutation_p.F161V|FANCD2_uc003buv.2_Missense_Mutation_p.F161V	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	161	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GCCAGAATATTTTTTTGAAAA	0.333			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.069288	0	20	93										G	10078013	T	G	10078013	3	3	41	1	0	0	0	0	1	0	0	0	5665	1841	64	5	503	5	FANCD2	3	10078013	Missense_Mutation	SNP	T	TCGA-DK-A1A5-01A-11D-A13W-08	112386	10078013	187944417	60	10478										
PLCL2	23228	broad.mit.edu	37	chr3	17053637	17053637	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atacgggatgccacagatctGagagaaaacatgcaggtgcg	13	8	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:17053637G>A	uc011awc.1	+	5	2880	c.2775G>A	c.(2773-2775)CTG>CTA	p.L925L	PLCL2_uc011awd.1_Silent_p.L807L	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	933					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CCACAGATCTGAGAGAAAACA	0.383													0	0	0	0.021553	0	5	25										A	17053637	G	A	17053637	2	1	41	1	0	0	0	0	0	0	0	1	12040	1277	45	1		1	PLCL2	3	17053637	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6975624	17053637	180968793	61	10479										
TRANK1	9881	broad.mit.edu	37	chr3	36872833	36872833	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggctccctggcctcctccctGacacgctccatctgggtgcc	10	19	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:36872833G>C	uc003cgj.2	-	12	6761	c.6459C>G	c.(6457-6459)GTC>GTG	p.V2153V		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2703					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CCTCCTCCCTGACACGCTCCA	0.592													0	0	0	0.055883	0	21	8										C	36872833	G	C	36872833	2	2	41	1	0	0	0	0	0	0	0	1	16451	1277	45	1		1	TRANK1	3	36872833	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	19819196	36872833	161149597	62	10480										
GOLGA4	2803	broad.mit.edu	37	chr3	37376609	37376609	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caacttgaggagctgcagaaGaaataccagcaaaagctaga	10	8	0	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:37376609G>A	uc003cgv.2	+	17	6562	c.6258G>A	c.(6256-6258)AAG>AAA	p.K2086K	GOLGA4_uc003cgw.2_Silent_p.K2108K|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Silent_p.K1967K	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	2086	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AGCTGCAGAAGAAATACCAGC	0.378													0	0	0	0.014758	0	4	10										A	37376609	G	A	37376609	2	1	41	1	0	0	0	0	0	0	0	1	6555	933	33	1		1	GOLGA4	3	37376609	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	503776	37376609	160645821	63	10481										
ENTPD3	956	broad.mit.edu	37	chr3	40457435	40457435	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccttcgtggcaggagagaaGatggatctgaacaccagcga	13	9	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:40457435G>A	uc003ckd.3	+	7	794	c.702G>A	c.(700-702)AAG>AAA	p.K234K	ENTPD3_uc010hhy.2_Silent_p.K234K|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	234	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		CAGGAGAGAAGATGGATCTGA	0.562													0	0	0	0.047766	0	9	22										A	40457435	G	A	40457435	2	1	41	1	0	0	0	0	0	0	0	1	5140	933	33	1		1	ENTPD3	3	40457435	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3080826	40457435	157564995	64	10482										
PTH1R	5745	broad.mit.edu	37	chr3	46940250	46940250	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caaggacgctgtgctctactCtggcgccacgcttgatgagg	13	12	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:46940250C>G	uc003cqm.2	+	9	940	c.737C>G	c.(736-738)TCT>TGT	p.S246C	PTH1R_uc003cqn.2_Missense_Mutation_p.S246C	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	246	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GTGCTCTACTCTGGCGCCACG	0.677									Ollier_disease_/_Maffuci_syndrome				0	0	0	0.083992	0	24	21										G	46940250	C	G	46940250	3	3	41	1	0	0	0	0	1	0	0	0	12758	913	32	1	763	1	PTH1R	3	46940250	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6482815	46940250	151082180	65	10483										
SETD2	29072	broad.mit.edu	37	chr3	47144868	47144868	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acaatttggttcacagctgtGattcatgaaacgagagcaat	9	7	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:47144868G>A	uc003cqs.2	-	7	4938	c.4885C>T	c.(4885-4887)CAC>TAC	p.H1629Y	SETD2_uc003cqv.2_Missense_Mutation_p.H1696Y	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1629	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R1629fs*15(1)		kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCACAGCTGTGATTCATGAAA	0.333			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.059317	0	33	125										A	47144868	G	A	47144868	3	1	41	1	0	0	0	0	1	0	0	0	14131	1290	45	1	2869	1	SETD2	3	47144868	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	204618	47144868	150877562	66	10484										
BAP1	8314	broad.mit.edu	37	chr3	52442604	52442604	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcgatccatttgaacaggaaGataaatccatatacagggct	8	8	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:52442604G>C	uc003ddx.2	-	4	256	c.141C>G	c.(139-141)ATC>ATG	p.I47M	PHF7_uc003ddy.2_5'Flank|PHF7_uc003ddz.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	47					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TGAACAGGAAGATAAATCCAT	0.473			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.004672	0	3	23										C	52442604	G	C	52442604	3	2	41	1	0	0	0	0	1	0	0	0	1311	932	33	1	2104	1	BAP1	3	52442604	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5297736	52442604	145579826	67	10485										
CADPS	8618	broad.mit.edu	37	chr3	62423823	62423823	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctcctcattgaccttatcacGcaggacatcctgagaatggc	8	13	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:62423823G>A	uc003dll.2	-	28	4093	c.3733C>T	c.(3733-3735)CGT>TGT	p.R1245C	CADPS_uc003dlj.1_Missense_Mutation_p.R200C|CADPS_uc003dlk.1_Missense_Mutation_p.R693C|CADPS_uc003dlm.2_Missense_Mutation_p.R1206C|CADPS_uc003dln.2_Missense_Mutation_p.R1166C	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1245	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ACCTTATCACGCAGGACATCC	0.448													0	0	0	0.009096	0	4	32										A	62423823	G	A	62423823	3	1	41	1	0	0	0	0	1	0	0	0	2570	1087	38	2	340	2	CADPS	3	62423823	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	9981219	62423823	135598607	68	10486										
CD86	942	broad.mit.edu	37	chr3	121825321	121825321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tctggaaactgacaagacgcGgcttttatcttcacctttct	7	11	4	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:121825321G>A	uc003eet.2	+	4	793	c.677G>A	c.(676-678)CGG>CAG	p.R226Q	CD86_uc011bjo.1_Missense_Mutation_p.R144Q|CD86_uc011bjp.1_Missense_Mutation_p.R114Q|CD86_uc003eeu.2_Missense_Mutation_p.R220Q	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	226	Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	GACAAGACGCGGCTTTTATCT	0.403													0	0	0	0.048971	0	55	66										A	121825321	G	A	121825321	3	1	41	1	0	0	0	0	1	0	0	0	3043	1116	39	2	691	2	CD86	3	121825321	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	59401498	121825321	76197109	69	10487										
KALRN	8997	broad.mit.edu	37	chr3	124380748	124380748	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaacgctgcaatgacatgatGaatctaggacgtctgcaggg	12	8	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:124380748G>A	uc003ehg.2	+	45	6442	c.6315G>A	c.(6313-6315)ATG>ATA	p.M2105I	KALRN_uc003ehi.2_Missense_Mutation_p.M446I|KALRN_uc003ehk.2_Missense_Mutation_p.M408I|KALRN_uc011bjz.1_Missense_Mutation_p.M197I	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2104					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGACATGATGAATCTAGGAC	0.507													0	0	0	0.048971	0	89	116										A	124380748	G	A	124380748	3	1	41	1	0	0	0	0	1	0	0	0	7975	1290	45	1	6649	1	KALRN	3	124380748	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2555427	124380748	73641682	70	10488										
COPB2	9276	broad.mit.edu	37	chr3	139085601	139085601	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gttgtctttaggaatgtagcCtaggagatacatcgtcctat	10	7	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:139085601C>T	uc003etf.3	-	15	1823	c.1693G>A	c.(1693-1695)GGC>AGC	p.G565S	COPB2_uc011bmv.1_Missense_Mutation_p.G536S|COPB2_uc010hui.2_Missense_Mutation_p.G536S	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	565					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						GGAATGTAGCCTAGGAGATAC	0.413													0	0	0	0.021553	0	5	26										T	139085601	C	T	139085601	3	4	41	1	0	0	0	0	1	0	0	0	3729	681	24	2	1059	2	COPB2	3	139085601	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	14704853	139085601	58936829	71	10489										
GPR149	344758	broad.mit.edu	37	chr3	154139250	154139250	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ataacttttttggaatgataGattgaattcaaagccttttc	6	5	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:154139250G>A	uc003faa.2	-	3	1301	c.1201C>T	c.(1201-1203)CTA>TTA	p.L401L		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	401	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGAATGATAGATTGAATTCA	0.284													0	0	0	0.014758	0	5	10										A	154139250	G	A	154139250	2	1	41	1	0	0	0	0	0	0	0	1	6654	933	33	1		1	GPR149	3	154139250	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	15053649	154139250	43883180	72	10490										
TRIM59	286827	broad.mit.edu	37	chr3	160156351	160156351	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	attagattgccaacatcacaGagagccgttaggaaactttt	8	8	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:160156351G>A	uc003fdm.2	-	3	816	c.621C>T	c.(619-621)CTC>CTT	p.L207L	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	207	Potential.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CAACATCACAGAGAGCCGTTA	0.353													0	0	0	0.09836	0	38	161										A	160156351	G	A	160156351	2	1	41	1	0	0	0	0	0	0	0	1	16529	929	33	1		1	TRIM59	3	160156351	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6017101	160156351	37866079	73	10491										
PIK3CA	5290	broad.mit.edu	37	chr3	178942564	178942564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agaacccagacatcatgtcaGagttactgtttcagaacaat	7	9	3	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr3:178942564G>C	uc003fjk.2	+	16	2528	c.2371G>C	c.(2371-2373)GAG>CAG	p.E791Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	791					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATCATGTCAGAGTTACTGTT	0.353		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.02938	0	7	23										C	178942564	G	C	178942564	3	2	41	1	0	0	0	0	1	0	0	0	11913	943	33	1	2429	1	PIK3CA	3	178942564	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	18786213	178942564	19079866	74	10492										
CTBP1	1487	broad.mit.edu	37	chr4	1206715	1206715	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gctcacctataggcagccccAttgagctcagggtgcacgac	11	14	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:1206715A>C	uc003gcv.1	-	8	1290	c.1125T>G	c.(1123-1125)AAT>AAG	p.N375K	uc003gcs.1_Intron|CTBP1_uc003gct.1_Missense_Mutation_p.N356K|CTBP1_uc003gcu.1_Missense_Mutation_p.N364K|CTBP1_uc003gcw.2_Missense_Mutation_p.N49K	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	375					interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		AGGCAGCCCCATTGAGCTCAG	0.667													0	0	0	0.024245	0	7	46										C	1206715	A	C	1206715	3	2	41	1	0	0	0	0	1	0	0	0	3997	214	8	5	205	5	CTBP1	4	1206715	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08		1206715	189947561	75	10493										
POLN	353497	broad.mit.edu	37	chr4	2130935	2130935	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaaaggtgtggcctttggatGaaacaaacatggccctcggg	14	8	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:2130935G>A	uc003ger.2	-	16	1838	c.1838C>T	c.(1837-1839)TCA>TTA	p.S613L	POLN_uc010icg.1_Missense_Mutation_p.S61L|POLN_uc010ich.1_Missense_Mutation_p.S145L	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	613					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			GCCTTTGGATGAAACAAACAT	0.398								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.062417	0	22	63										A	2130935	G	A	2130935	3	1	41	1	0	0	0	0	1	0	0	0	12207	1294	45	1	900	1	POLN	4	2130935	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	924220	2130935	189023341	76	10494										
ABLIM2	84448	broad.mit.edu	37	chr4	7985051	7985051	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cgaattcggtttgtgacgatGagggagtcatacggatagat	14	5	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:7985051G>C	uc003gko.2	-	19	1805	c.1662C>G	c.(1660-1662)CTC>CTG	p.L554L	ABLIM2_uc003gkk.2_Silent_p.L179L|ABLIM2_uc003gkl.2_Silent_p.L282L|ABLIM2_uc003gkj.3_Silent_p.L588L|ABLIM2_uc003gkm.3_Silent_p.L502L|ABLIM2_uc003gkp.2_Silent_p.L474L|ABLIM2_uc003gkq.2_Silent_p.L515L|ABLIM2_uc003gkr.2_Silent_p.L464L|ABLIM2_uc003gki.2_RNA	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	554	HP.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						TTGTGACGATGAGGGAGTCAT	0.562													0	0	0	0.021553	0	6	25										C	7985051	G	C	7985051	2	2	41	1	0	0	0	0	0	0	0	1	95	1277	45	1		1	ABLIM2	4	7985051	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5854116	7985051	183169225	77	10495										
GPR125	166647	broad.mit.edu	37	chr4	22449100	22449100	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aagataatcaaaagttccttGagataatgaagaaaacaaat	6	4	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:22449100G>A	uc003gqm.1	-	5	773	c.508C>T	c.(508-510)CAA>TAA	p.Q170*	GPR125_uc010ieo.1_Nonsense_Mutation_p.Q44*|GPR125_uc003gqo.2_Nonsense_Mutation_p.Q170*	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	170	Extracellular (Potential).|LRR 4.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				AAAGTTCCTTGAGATAATGAA	0.249													0	0	0	0.020292	0	12	30										A	22449100	G	A	22449100	4	1	41	1	0	0	0	0	0	1	0	0	6639	1299	45	1	3517	1	GPR125	4	22449100	Nonsense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	14464049	22449100	168705176	78	10496										
FRYL	285527	broad.mit.edu	37	chr4	48517148	48517148	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gactgactcggggtaactttCaggagctagaggctctggca	14	9	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:48517148C>T	uc003gyh.1	-	56	8439	c.7834G>A	c.(7834-7836)GAA>AAA	p.E2612K	FRYL_uc003gyf.1_Missense_Mutation_p.E8K|FRYL_uc003gyg.1_Missense_Mutation_p.E1308K|FRYL_uc003gyi.1_Missense_Mutation_p.E1500K	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2612					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GGGTAACTTTCAGGAGCTAGA	0.423													0	0	0	0.076483	0	23	29										T	48517148	C	T	48517148	3	4	41	1	0	0	0	0	1	0	0	0	6064	835	29	1	1243	1	FRYL	4	48517148	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	26068048	48517148	142637128	79	10497										
NPFFR2	10886	broad.mit.edu	37	chr4	73013407	73013407	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acacatctaatcagcttgtcCaggaatctacatttcaaaac	4	11	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:73013407C>T	uc003hgg.2	+	4	1545	c.1447C>T	c.(1447-1449)CAG>TAG	p.Q483*	NPFFR2_uc010iig.1_Nonsense_Mutation_p.Q265*|NPFFR2_uc003hgi.2_Nonsense_Mutation_p.Q384*|NPFFR2_uc003hgh.2_Nonsense_Mutation_p.Q381*|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	483	Cytoplasmic (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TCAGCTTGTCCAGGAATCTAC	0.403													0	0	0	0.024245	0	14	31										T	73013407	C	T	73013407	4	4	41	1	0	0	0	0	0	1	0	0	10578	595	21	2	1467	2	NPFFR2	4	73013407	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	24496259	73013407	118140869	80	10498										
PPEF2	5470	broad.mit.edu	37	chr4	76794444	76794444	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccctcttgagccatgggatCactccacaggatatctacaa	8	13	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:76794444C>T	uc003hix.2	-	12	1699	c.1342G>A	c.(1342-1344)GAT>AAT	p.D448N	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Missense_Mutation_p.D448N	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	448	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCCATGGGATCACTCCACAGG	0.433													0	0	0	0.048971	0	49	81										T	76794444	C	T	76794444	3	4	41	1	0	0	0	0	1	0	0	0	12308	826	29	1	943	1	PPEF2	4	76794444	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3781037	76794444	114359832	81	10499										
ADH1B	125	broad.mit.edu	37	chr4	100235073	100235073	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aatgggtttcttgtagtcttGagggttgatgcattcagtgg	14	4	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:100235073G>C	uc003hus.3	-	6	817	c.733C>G	c.(733-735)CAA>GAA	p.Q245E	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.Q205E|ADH1B_uc011ceh.1_Missense_Mutation_p.Q90E|ADH1B_uc011cei.1_Missense_Mutation_p.Q205E	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	245					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTGTAGTCTTGAGGGTTGATG	0.468													0	0	0	0.048971	0	79	93										C	100235073	G	C	100235073	3	2	41	1	0	0	0	0	1	0	0	0	308	1299	45	1	410	1	ADH1B	4	100235073	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	23440629	100235073	90919203	82	10500										
ADAM29	11086	broad.mit.edu	37	chr4	175897020	175897020	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggacccagaatccctggtttCcctcagtacctgttttgggg	11	12	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr4:175897020C>T	uc003iuc.2	+	5	1014	c.344C>T	c.(343-345)TCC>TTC	p.S115F	ADAM29_uc003iud.2_Missense_Mutation_p.S115F|ADAM29_uc010irr.2_Missense_Mutation_p.S115F|ADAM29_uc011cki.1_Missense_Mutation_p.S115F	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	115					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TCCCTGGTTTCCCTCAGTACC	0.443													0	0	0	0.047766	0	9	31										T	175897020	C	T	175897020	3	4	41	1	0	0	0	0	1	0	0	0	247	855	30	1	346	1	ADAM29	4	175897020	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	75661947	175897020	15257256	83	10501										
MARCH6	10299	broad.mit.edu	37	chr5	10391786	10391786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aagaggaggaggaggacaatGaggaggaagatgacgctggt	19	3	0	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:10391786G>C	uc003jet.1	+	7	892	c.709G>C	c.(709-711)GAG>CAG	p.E237Q	MARCH6_uc011cmu.1_Missense_Mutation_p.E189Q|MARCH6_uc003jeu.1_5'UTR|MARCH6_uc011cmv.1_Missense_Mutation_p.E132Q	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	237	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						ggaggacaatgaggaggaaga	0.433													0	0	0	0.076483	0	23	24										C	10391786	G	C	10391786	3	2	41	1	0	0	0	0	1	0	0	0	9305	1291	45	1	735	1	MARCH6	5	10391786	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		10391786	170523474	84	10502										
C1QTNF3	114899	broad.mit.edu	37	chr5	34043213	34043213	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccagcagttgccaatagatGagctgcctccaaagcatgat	10	11	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:34043213G>T	uc003jin.2	-	1	105	c.18C>A	c.(16-18)CTC>CTA	p.L6L	C1QTNF3_uc003jio.2_Silent_p.L6L	NM_030945	NP_112207	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	6						collagen					0	all_lung(31;0.0207)					GCCAATAGATGAGCTGCCTCC	0.507													1	0	3.86212e-05	0.069234	3.92937e-05	11	36										T	34043213	G	T	34043213	2	4	41	1	0	0	0	0	0	0	0	1	1964	1277	45	3		3	C1QTNF3	5	34043213	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	23651427	34043213	146872047	85	10503										
NIPBL	25836	broad.mit.edu	37	chr5	37020905	37020905	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgatactgtggactatgatGatgcttgcttgattgttcga	11	6	0	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:37020905G>A	uc003jkl.3	+	27	5753	c.5254G>A	c.(5254-5256)GAT>AAT	p.D1752N	NIPBL_uc003jkk.3_Missense_Mutation_p.D1752N	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1752					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GGACTATGATGATGCTTGCTT	0.348													0	0	0	0.048971	0	56	208										A	37020905	G	A	37020905	3	1	41	1	0	0	0	0	1	0	0	0	10428	1290	45	1	5356	1	NIPBL	5	37020905	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2977692	37020905	143894355	86	10504										
NNT	23530	broad.mit.edu	37	chr5	43650630	43650630	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gggaggacatttgtatccttCcacaacttctcagggccttg	10	11	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:43650630C>A	uc003joe.2	+	12	1913	c.1658C>A	c.(1657-1659)TCC>TAC	p.S553Y	NNT_uc003jof.2_Missense_Mutation_p.S553Y	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	553					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	TTGTATCCTTCCACAACTTCT	0.443													1	0	6.44725e-10	0.069288	6.69271e-10	19	53										A	43650630	C	A	43650630	3	1	41	1	0	0	0	0	1	0	0	0	10510	855	30	3	1700	3	NNT	5	43650630	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6629725	43650630	137264630	87	10505										
F2RL1	2150	broad.mit.edu	37	chr5	76128897	76128897	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aatgtgcttattggctttttCtatggcaacatgtactgttc	8	7	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:76128897C>G	uc003keo.2	+	2	640	c.465C>G	c.(463-465)TTC>TTG	p.F155L		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	155	Helical; Name=3; (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		TTGGCTTTTTCTATGGCAACA	0.468													0	0	0	0.048971	0	115	294										G	76128897	C	G	76128897	3	3	41	1	0	0	0	0	1	0	0	0	5344	912	32	1	471	1	F2RL1	5	76128897	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	32478267	76128897	104786363	88	10506										
LYSMD3	116068	broad.mit.edu	37	chr5	89815090	89815090	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttttaaaaagctaccagctGagtcactgtaagcaagagaa	8	8	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:89815090G>A	uc003kjr.2	-	3	615	c.467C>T	c.(466-468)TCA>TTA	p.S156L	LYSMD3_uc010jaz.1_Intron|LYSMD3_uc003kjs.1_3'UTR	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	156	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		GCTACCAGCTGAGTCACTGTA	0.398													0	0	0	0.020292	0	14	41										A	89815090	G	A	89815090	3	1	41	1	0	0	0	0	1	0	0	0	9126	1294	45	1	457	1	LYSMD3	5	89815090	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	13686193	89815090	91100170	89	10507										
MYOT	9499	broad.mit.edu	37	chr5	137222941	137222941	+	Frame_Shift_Del	DEL	G	G	-													0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccagctcctaagcagttacGggttcgaccaacattcagca					rs141801816	byFrequency	TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:137222941delG	uc011cye.1	+	10	1381	c.1364delG	c.(1363-1365)CGGfs	p.R455fs	PKD2L2_uc010jep.1_5'Flank|PKD2L2_uc003lbw.1_5'Flank|PKD2L2_uc003lbx.2_5'Flank|PKD2L2_uc003lby.2_5'Flank|MYOT_uc003lbv.2_Frame_Shift_Del_p.R455fs|MYOT_uc011cyg.1_Frame_Shift_Del_p.R271fs|MYOT_uc011cyh.1_Frame_Shift_Del_p.R340fs	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	455	Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AAGCAGTTACGGGTTCGACCA	0.393																		42	133	---	---								-	137222941	G	-	137222941	7	5	41	1	0	1	0	1	0	0	0	0	10094	1116	39	0	1398	0	MYOT	5	137222941	Frame_Shift_Del	DEL	G	TCGA-DK-A1A5-01A-11D-A13W-08	47407851	137222941	43692319	90	10508										
PCDHB8	56128	broad.mit.edu	37	chr5	140558048	140558048	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaatgttggtgaaagtatcaGagagcagtcctcctgggact	12	7	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:140558048G>A	uc011dai.1	+	1	619	c.433G>A	c.(433-435)GAG>AAG	p.E145K	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	145	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAAGTATCAGAGAGCAGTCC	0.418													0	0	0	0.048971	0	49	267										A	140558048	G	A	140558048	3	1	41	1	0	0	0	0	1	0	0	0	11548	943	33	1	435	1	PCDHB8	5	140558048	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3335107	140558048	40357212	91	10509										
SLC25A2	83884	broad.mit.edu	37	chr5	140683343	140683343	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atcttcacttttattgtgtcGaagggctgcccagtcagtac	9	10	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:140683343G>A	uc003ljf.2	-	1	270	c.90C>T	c.(88-90)TTC>TTT	p.F30F		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	30	Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TTATTGTGTCGAAGGGCTGCC	0.597													0	0	0	0.038395	0	17	40										A	140683343	G	A	140683343	2	1	41	1	0	0	0	0	0	0	0	1	14482	1049	37	1		1	SLC25A2	5	140683343	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	125295	140683343	40231917	92	10510										
PCDHGB4	8641	broad.mit.edu	37	chr5	140769192	140769192	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atatggtgccgcacgctgcaGagcctggctacttggtgacc	13	12	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:140769192G>C	uc003lkc.1	+	1	1741	c.1741G>C	c.(1741-1743)GAG>CAG	p.E581Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.E581Q	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	581	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACGCTGCAGAGCCTGGCTA	0.652													0	0	0	0.09319	0	12	39										C	140769192	G	C	140769192	3	2	41	1	0	0	0	0	1	0	0	0	11565	943	33	1	1743	1	PCDHGB4	5	140769192	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	85849	140769192	40146068	93	10511										
SLC36A3	285641	broad.mit.edu	37	chr5	150666828	150666828	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccatgatatactcaaagatCagagccatgctcccaagggt	8	11	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:150666828C>T	uc003ltw.2	-	6	1106	c.687G>A	c.(685-687)CTG>CTA	p.L229L	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.L214L|SLC36A3_uc003ltx.2_Silent_p.L270L	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	229	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACTCAAAGATCAGAGCCATGC	0.517													0	0	0	0.0333	0	17	40										T	150666828	C	T	150666828	2	4	41	1	0	0	0	0	0	0	0	1	14595	813	29	1		1	SLC36A3	5	150666828	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9897636	150666828	30248432	94	10512										
G3BP1	10146	broad.mit.edu	37	chr5	151179852	151179852	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cctgacagtcaccaactcttCattggcaacctgcctcatga	6	15	4	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:151179852C>T	uc003lun.2	+	10	1200	c.1029C>T	c.(1027-1029)TTC>TTT	p.F343F	G3BP1_uc003lum.2_Silent_p.F343F|G3BP1_uc011dcu.1_Silent_p.F161F|G3BP1_uc010jhz.2_Silent_p.F161F|G3BP1_uc003luq.2_Silent_p.F11F	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	343	RRM.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			ACCAACTCTTCATTGGCAACC	0.418													0	0	0	0.108266	0	26	53										T	151179852	C	T	151179852	2	4	41	1	0	0	0	0	0	0	0	1	6141	825	29	1		1	G3BP1	5	151179852	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	513024	151179852	29735408	95	10513										
GABRA6	2559	broad.mit.edu	37	chr5	161116651	161116651	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caaatatttagatgcttatcCcaaaagtgaaatcatatata	4	6	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:161116651C>A	uc003lyu.2	+	6	877	c.539C>A	c.(538-540)CCC>CAC	p.P180H	GABRA6_uc003lyv.2_5'UTR	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	180	Extracellular (Probable).		P -> H (in a colorectal cancer sample; somatic mutation).		gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity	p.P180H(1)		ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GATGCTTATCCCAAAAGTGAA	0.328										TCGA Ovarian(5;0.080)			1	0	1.06961e-07	0.038147	1.09918e-07	6	15										A	161116651	C	A	161116651	3	1	41	1	0	0	0	0	1	0	0	0	6165	623	22	4	561	4	GABRA6	5	161116651	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9936799	161116651	19798609	96	10514										
SLC34A1	6569	broad.mit.edu	37	chr5	176815096	176815096	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctacctgcaccacatcactcGacttgtggtggcctccttca	7	16	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:176815096G>A	uc003mgk.3	+	7	847	c.746G>A	c.(745-747)CGA>CAA	p.R249Q		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	249	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACATCACTCGACTTGTGGTG	0.592													0	0	0	0.043863	0	17	47										A	176815096	G	A	176815096	3	1	41	1	0	0	0	0	1	0	0	0	14567	1058	37	1	768	1	SLC34A1	5	176815096	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	15698445	176815096	4100164	97	10515										
RUFY1	80230	broad.mit.edu	37	chr5	179023597	179023597	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agcgggcgaggcagggggctGaggagcggagccacaagctg	21	9	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr5:179023597G>A	uc003mka.1	+	13	1546	c.1546G>A	c.(1546-1548)GAG>AAG	p.E516K	RUFY1_uc003mkb.1_Missense_Mutation_p.E408K|RUFY1_uc003mkc.1_Missense_Mutation_p.E408K|RUFY1_uc003mkd.1_Missense_Mutation_p.E118K	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	516	Potential.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGGGGGCTGAGGAGCGGAG	0.617										HNSCC(44;0.11)			0	0	0	0.048971	0	48	123										A	179023597	G	A	179023597	3	1	41	1	0	0	0	0	1	0	0	0	13738	1291	45	1	1596	1	RUFY1	5	179023597	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2208501	179023597	1891663	98	10516										
RPP40	10799	broad.mit.edu	37	chr6	4996532	4996532	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggacacctctggcgttccctCcagctcgctgctctgcagca	10	17	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:4996532C>T	uc003mwl.2	-	6	717	c.682G>A	c.(682-684)GAG>AAG	p.E228K	RPP40_uc003mwm.2_Missense_Mutation_p.E205K	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	228					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				GGCGTTCCCTCCAGCTCGCTG	0.557													0	0	0	0.104719	0	43	84										T	4996532	C	T	4996532	3	4	41	1	0	0	0	0	1	0	0	0	13614	864	30	1	421	1	RPP40	6	4996532	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		4996532	166118535	99	10517										
RREB1	6239	broad.mit.edu	37	chr6	7231959	7231959	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aacactcaggatgaggtggcCggagcccctgccgaccacca	12	15	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:7231959C>T	uc003mxc.2	+	10	4017	c.3627C>T	c.(3625-3627)GCC>GCT	p.A1209A	RREB1_uc003mxb.2_Silent_p.A1209A|RREB1_uc010jnx.2_Silent_p.A1209A	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	1209					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				ATGAGGTGGCCGGAGCCCCTG	0.602													0	0	0	0.049695	0	18	28										T	7231959	C	T	7231959	2	4	41	1	0	0	0	0	0	0	0	1	13679	639	23	2		2	RREB1	6	7231959	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2235427	7231959	163883108	100	10518										
HIVEP1	3096	broad.mit.edu	37	chr6	12122972	12122972	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaaatcataagaaattttacTgttctgagttacatggacca	6	6	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:12122972T>A	uc003nac.2	+	4	3123	c.2944T>A	c.(2944-2946)TGT>AGT	p.C982S	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	982	C2H2-type 3.				transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GAAATTTTACTGTTCTGAGTT	0.428													0	0	0	0.059317	0	37	78										A	12122972	T	A	12122972	3	1	41	1	0	0	0	0	1	0	0	0	7186	1580	55	5	2954	5	HIVEP1	6	12122972	Missense_Mutation	SNP	T	TCGA-DK-A1A5-01A-11D-A13W-08	4891013	12122972	158992095	101	10519										
SLC17A4	10050	broad.mit.edu	37	chr6	25773814	25773814	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	actctgggccattttagtctCttatttctgtgaatactggc	8	9	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:25773814C>G	uc003nfe.2	+	8	1018	c.899C>G	c.(898-900)TCT>TGT	p.S300C	SLC17A4_uc011djx.1_Intron|SLC17A4_uc003nff.1_Missense_Mutation_p.S61C|SLC17A4_uc003nfg.2_Missense_Mutation_p.S237C|SLC17A4_uc010jqa.2_Missense_Mutation_p.S13C	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	300	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						ATTTTAGTCTCTTATTTCTGT	0.448													0	0	0	0.004672	0	3	32										G	25773814	C	G	25773814	3	3	41	1	0	0	0	0	1	0	0	0	14419	913	32	1	925	1	SLC17A4	6	25773814	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	13650842	25773814	145341253	102	10520										
BTN2A1	11120	broad.mit.edu	37	chr6	26459787	26459787	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tacgttacgctgccatctgtCacccgagaaaaatgctgagg	10	11	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:26459787C>T	uc003nib.1	+	3	373	c.161C>T	c.(160-162)TCA>TTA	p.S54L	BTN2A1_uc003nic.1_Missense_Mutation_p.S54L|BTN2A1_uc003nid.1_5'UTR|BTN2A1_uc011dko.1_5'UTR	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	54	Extracellular (Potential).|Ig-like V-type.				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						TGCCATCTGTCACCCGAGAAA	0.532													0	0	0	0.105934	0	13	65										T	26459787	C	T	26459787	3	4	41	1	0	0	0	0	1	0	0	0	1560	838	29	1	167	1	BTN2A1	6	26459787	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	685973	26459787	144655280	103	10521										
HIST1H2AG	8969	broad.mit.edu	37	chr6	27100942	27100942	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccagttccccgtgggccgagTgcaccgcctgctccgcaaag	12	17	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:27100942T>G	uc003niw.2	+	1	126	c.92T>G	c.(91-93)GTG>GGG	p.V31G	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	31					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GTGGGCCGAGTGCACCGCCTG	0.677													0	0	0	0.0333	0	10	56										G	27100942	T	G	27100942	3	3	41	1	0	0	0	0	1	0	0	0	7133	1696	59	5	94	5	HIST1H2AG	6	27100942	Missense_Mutation	SNP	T	TCGA-DK-A1A5-01A-11D-A13W-08	641155	27100942	144014125	104	10522										
VARS2	57176	broad.mit.edu	37	chr6	30882669	30882669	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	attttgggggctgaggcactCacggggcctccccaggtttc	14	12	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:30882669C>T	uc003nsc.1	+	1	688	c.56C>T	c.(55-57)TCA>TTA	p.S19L	GTF2H4_uc003nsb.1_3'UTR|VARS2_uc003nsd.2_Missense_Mutation_p.S19L|VARS2_uc011dmx.1_Missense_Mutation_p.S19L|VARS2_uc011dmy.1_Intron|VARS2_uc011dmz.1_Missense_Mutation_p.S49L|VARS2_uc011dna.1_Missense_Mutation_p.S19L|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	19					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CTGAGGCACTCACGGGGCCTC	0.572													0	0	0	0.048971	0	55	101										T	30882669	C	T	30882669	3	4	41	1	0	0	0	0	1	0	0	0	17121	838	29	1	152	1	VARS2	6	30882669	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3781727	30882669	140232398	105	10523										
RNF5	6048	broad.mit.edu	37	chr6	32147331	32147331	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	catccagttggccatgtcttCatcaggtgcgtactcaggag	11	11	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:32147331C>T	uc003oaj.3	+	2	281	c.154C>T	c.(154-156)CAT>TAT	p.H52Y	AGPAT1_uc003oaf.2_5'Flank|AGPAT1_uc003oag.2_5'Flank|AGPAT1_uc003oah.2_5'Flank	NM_006913	NP_008844	Q99942	RNF5_HUMAN	ring finger protein 5	52	RING-type.				ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCCATGTCTTCATCAGGTGCG	0.473													0	0	0	0.048971	0	285	511										T	32147331	C	T	32147331	3	4	41	1	0	0	0	0	1	0	0	0	13497	826	29	1	160	1	RNF5	6	32147331	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1264662	32147331	138967736	106	10524										
B3GALT4	8705	broad.mit.edu	37	chr6	33246064	33246064	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gggcaccccttctcccattaGaggatgtctttgtgggggta	13	10	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:33246064G>C	uc003odr.2	+	1	1148	c.868G>C	c.(868-870)GAG>CAG	p.E290Q		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	290	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						TCTCCCATTAGAGGATGTCTT	0.622													0	0	0	0.108266	0	27	156										C	33246064	G	C	33246064	3	2	41	1	0	0	0	0	1	0	0	0	1249	943	33	1	870	1	B3GALT4	6	33246064	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1098733	33246064	137869003	107	10525										
DNAH8	1769	broad.mit.edu	37	chr6	38810631	38810631	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaatctgattctttttgcctTagaaatatcatggaagcacc	7	8	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:38810631T>C	uc003ooe.1	+	33	4746	c.4146T>C	c.(4144-4146)CTT>CTC	p.L1382L		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CTTTTTGCCTTAGAAATATCA	0.373													0	0	0	0.021553	0	6	52										C	38810631	T	C	38810631	2	2	41	1	0	0	0	0	0	0	0	1	4607	1741	61	5		5	DNAH8	6	38810631	Silent	SNP	T	TCGA-DK-A1A5-01A-11D-A13W-08	5564567	38810631	132304436	108	10526										
TBCC	6903	broad.mit.edu	37	chr6	42712930	42712930	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttgtcgatctccgggtagctCcaggtgtaaggggcgaactg	15	9	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:42712930C>G	uc003osl.2	-	1	955	c.882G>C	c.(880-882)TGG>TGC	p.W294C		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	294	C-CAP/cofactor C-like.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			CCGGGTAGCTCCAGGTGTAAG	0.537													0	0	0	0.048971	0	48	126										G	42712930	C	G	42712930	3	3	41	1	0	0	0	0	1	0	0	0	15628	856	30	1	162	1	TBCC	6	42712930	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3902299	42712930	128402137	109	10527			1	43		3	3	285	C		4.339363e-06
TBCC	6903	broad.mit.edu	37	chr6	42713073	42713073	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cacgcagtcactgcagtcctCcaggaaaacagaggtagaca	10	12	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:42713073C>G	uc003osl.2	-	1	812	c.739G>C	c.(739-741)GAG>CAG	p.E247Q		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	247	C-CAP/cofactor C-like.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			CTGCAGTCCTCCAGGAAAACA	0.592													0	0	0	0.064281	0	35	85										G	42713073	C	G	42713073	3	3	41	1	0	0	0	0	1	0	0	0	15628	864	30	1	305	1	TBCC	6	42713073	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	143	42713073	128401994	110	10528			1	43		3	3	285	C		4.339363e-06
TBCC	6903	broad.mit.edu	37	chr6	42713214	42713214	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aacgtcgcgctggtgcaactCgctggctctcttctccaaga	10	14	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:42713214C>G	uc003osl.2	-	1	671	c.598G>C	c.(598-600)GAG>CAG	p.E200Q		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	200	C-CAP/cofactor C-like.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			TGGTGCAACTCGCTGGCTCTC	0.602													0	0	0	0.076483	0	23	34										G	42713214	C	G	42713214	3	3	41	1	0	0	0	0	1	0	0	0	15628	893	31	1	446	1	TBCC	6	42713214	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	141	42713214	128401853	111	10529			1	43		3	3	285	C		4.339363e-06
RCAN2	10231	broad.mit.edu	37	chr6	46214588	46214588	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggggaggaagggggcgagatGagaaactgtttggcaggctg	21	4	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:46214588G>C	uc003oyb.1	-	3	645	c.330C>G	c.(328-330)CTC>CTG	p.L110L	RCAN2_uc003oyc.1_Silent_p.L156L|RCAN2_uc003oyd.1_Silent_p.L156L	NM_005822	NP_005813	Q14206	RCAN2_HUMAN	Down syndrome critical region gene 1-like 1	110					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding				0						GGGGCGAGATGAGAAACTGTT	0.522													0	0	0	0.021553	0	5	23										C	46214588	G	C	46214588	2	2	41	1	0	0	0	0	0	0	0	1	13169	1277	45	1		1	RCAN2	6	46214588	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3501374	46214588	124900479	112	10530										
CASP8AP2	9994	broad.mit.edu	37	chr6	90576496	90576496	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gctttggaagagatagtgatGaaggcaaacttgaaaaaaca	11	4	0	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:90576496G>A	uc003pnr.2	+	8	3683	c.3487G>A	c.(3487-3489)GAA>AAA	p.E1163K	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1163K|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1163K	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1163					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AGATAGTGATGAAGGCAAACT	0.328													0	0	0	0.014758	0	5	24										A	90576496	G	A	90576496	3	1	41	1	0	0	0	0	1	0	0	0	2678	1291	45	1	3513	1	CASP8AP2	6	90576496	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	44361908	90576496	80538571	113	10531										
MICAL1	64780	broad.mit.edu	37	chr6	109766413	109766413	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cactcactgctctggcgcctCaaggccagctccagcttcac	8	18	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:109766413C>G	uc003ptj.2	-	21	3122	c.2868G>C	c.(2866-2868)TTG>TTC	p.L956F	MICAL1_uc003ptk.2_Missense_Mutation_p.L956F|MICAL1_uc010kdr.2_Missense_Mutation_p.L870F|MICAL1_uc011eaq.1_Missense_Mutation_p.L975F	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	956	Potential.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TCTGGCGCCTCAAGGCCAGCT	0.592													0	0	0	0.024245	0	14	74										G	109766413	C	G	109766413	3	3	41	1	0	0	0	0	1	0	0	0	9569	825	29	1	351	1	MICAL1	6	109766413	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	19189917	109766413	61348654	114	10532										
MICAL1	64780	broad.mit.edu	37	chr6	109766439	109766439	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagctccagcttcacgccctCggcctctagctccctcaagg	8	19	3	0	rs147968137	byFrequency	TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:109766439C>T	uc003ptj.2	-	21	3096	c.2842G>A	c.(2842-2844)GAG>AAG	p.E948K	MICAL1_uc003ptk.2_Missense_Mutation_p.E948K|MICAL1_uc010kdr.2_Missense_Mutation_p.E862K|MICAL1_uc011eaq.1_Missense_Mutation_p.E967K	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	948	Potential.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TTCACGCCCTCGGCCTCTAGC	0.567													0	0	0	0.024245	0	14	66										T	109766439	C	T	109766439	3	4	41	1	0	0	0	0	1	0	0	0	9569	893	31	1	377	1	MICAL1	6	109766439	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	26	109766439	61348628	115	10533										
ROS1	6098	broad.mit.edu	37	chr6	117746802	117746802	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttgacaagcttcggaataagAcagtaaatgttcttcatcac	7	8	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:117746802A>G	uc003pxp.1	-	1	217	c.18T>C	c.(16-18)TGT>TGC	p.C6C	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	6					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TCGGAATAAGACAGTAAATGT	0.383			T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.09319	0	12	54										G	117746802	A	G	117746802	2	3	41	1	0	0	0	0	0	0	0	1	13531	273	10	5		5	ROS1	6	117746802	Silent	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	7980363	117746802	53368265	116	10534										
MAP3K5	4217	broad.mit.edu	37	chr6	137041602	137041602	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aggtaccttcagtgactgcaGagagtccgagttagtatcac	11	9	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:137041602G>C	uc003qhc.2	-	2	935	c.574C>G	c.(574-576)CTG>GTG	p.L192V	MAP3K5_uc011edk.1_Missense_Mutation_p.L37V|MAP3K5_uc010kgw.1_Missense_Mutation_p.L192V	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	192					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		AGTGACTGCAGAGAGTCCGAG	0.443													0	0	0	0.020292	0	15	13										C	137041602	G	C	137041602	3	2	41	1	0	0	0	0	1	0	0	0	9253	933	33	1	3666	1	MAP3K5	6	137041602	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	19294800	137041602	34073465	117	10535										
PLEKHG1	57480	broad.mit.edu	37	chr6	151152717	151152717	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtggtaacttgtctatgcctCataagcctgtatctgataaa	8	8	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:151152717C>G	uc003qny.1	+	16	2782	c.2470C>G	c.(2470-2472)CAT>GAT	p.H824D	PLEKHG1_uc011eel.1_Missense_Mutation_p.H864D|PLEKHG1_uc011eem.1_Missense_Mutation_p.H883D|PLEKHG1_uc003qnz.2_Missense_Mutation_p.H824D	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	824					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GTCTATGCCTCATAAGCCTGT	0.458													0	0	0	0.048971	0	123	155										G	151152717	C	G	151152717	3	3	41	1	0	0	0	0	1	0	0	0	12068	826	29	1	2524	1	PLEKHG1	6	151152717	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	14111115	151152717	19962350	118	10536										
SYNE1	23345	broad.mit.edu	37	chr6	152583252	152583252	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtaggctttcccatttcattCtcatctggtcttcagcggat	8	11	5	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr6:152583252C>T	uc010kiw.2	-	101	19489	c.18887G>A	c.(18886-18888)AGA>AAA	p.R6296K	SYNE1_uc010kiv.2_Missense_Mutation_p.R820K|SYNE1_uc003qos.3_Missense_Mutation_p.R820K|SYNE1_uc003qot.3_Missense_Mutation_p.R6225K|SYNE1_uc003qou.3_Missense_Mutation_p.R6296K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6296	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCATTTCATTCTCATCTGGTC	0.378										HNSCC(10;0.0054)			0	0	0	0.076483	0	23	61										T	152583252	C	T	152583252	3	4	41	1	0	0	0	0	1	0	0	0	15442	913	32	1	7763	1	SYNE1	6	152583252	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1430535	152583252	18531815	119	10537										
IQCE	23288	broad.mit.edu	37	chr7	2632715	2632715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggagaaggagctggagtgcgCgagggagggcgaggaggaga	24	4	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:2632715C>T	uc003smo.3	+	15	1488	c.1304C>T	c.(1303-1305)GCG>GTG	p.A435V	IQCE_uc010ksm.1_Missense_Mutation_p.A435V|IQCE_uc003sml.1_Missense_Mutation_p.A435V|IQCE_uc011jvy.1_Missense_Mutation_p.A419V|IQCE_uc011jvz.1_Missense_Mutation_p.A370V|IQCE_uc003smk.3_Missense_Mutation_p.A419V|IQCE_uc003smn.3_Missense_Mutation_p.A370V	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	435	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		ctggagtgcgcgagggagggc	0.413													0	0	0	0.050027	0	34	159										T	2632715	C	T	2632715	3	4	41	1	0	0	0	0	1	0	0	0	7806	768	27	2	1362	2	IQCE	7	2632715	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		2632715	156505948	120	10538										
RNF216	54476	broad.mit.edu	37	chr7	5781044	5781044	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagctctgtctctgagtcttCggatgactggttctgagttt	11	9	4	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:5781044C>T	uc003soy.1	-	4	623	c.433G>A	c.(433-435)GAA>AAA	p.E145K	RNF216_uc010ksz.1_5'UTR|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Missense_Mutation_p.E202K	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	145					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TCTGAGTCTTCGGATGACTGG	0.453													0	0	0	0.048971	0	76	373										T	5781044	C	T	5781044	3	4	41	1	0	0	0	0	1	0	0	0	13480	893	31	1	2223	1	RNF216	7	5781044	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3148329	5781044	153357619	121	10539										
DAGLB	221955	broad.mit.edu	37	chr7	6476128	6476128	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggcggatgtaaagcagcttaGacatagacttccgcggtcca	12	10	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:6476128G>C	uc003sqa.2	-	3	454	c.284C>G	c.(283-285)TCT>TGT	p.S95C	DAGLB_uc011jwt.1_5'Flank|DAGLB_uc011jwu.1_Missense_Mutation_p.S95C|DAGLB_uc003sqb.2_Intron|DAGLB_uc003sqc.2_Intron|DAGLB_uc011jwv.1_Intron|DAGLB_uc003sqd.3_Missense_Mutation_p.S54C|DAGLB_uc011jww.1_Intron	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	95	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		AAGCAGCTTAGACATAGACTT	0.517													0	0	0	0.048971	0	104	90										C	6476128	G	C	6476128	3	2	41	1	0	0	0	0	1	0	0	0	4227	942	33	1	1786	1	DAGLB	7	6476128	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	695084	6476128	152662535	122	10540										
ITGB8	3696	broad.mit.edu	37	chr7	20438615	20438615	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaaacgtgacgagcaatgatGaagtatgtgggtgtgcattt	14	4	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:20438615G>A	uc003suu.2	+	9	1984	c.1279G>A	c.(1279-1281)GAA>AAA	p.E427K	ITGB8_uc011jyh.1_Missense_Mutation_p.E292K|ITGB8_uc003sut.2_Missense_Mutation_p.E427K	NM_002214	NP_002205	P26012	ITB8_HUMAN	integrin, beta 8 precursor	427	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			skin(3)	3						GAGCAATGATGAAGTATGTGG	0.388													0	0	0	0.069234	0	11	27										A	20438615	G	A	20438615	3	1	41	1	0	0	0	0	1	0	0	0	7901	1291	45	1	1313	1	ITGB8	7	20438615	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	13962487	20438615	138700048	123	10541										
KLHL7	55975	broad.mit.edu	37	chr7	23180423	23180423	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cggagtgtctagattgtcctGaattgaaagcaactgcagat	11	7	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:23180423G>A	uc003svs.3	+	5	771	c.478G>A	c.(478-480)GAA>AAA	p.E160K	KLHL7_uc003svr.3_Missense_Mutation_p.E138K|KLHL7_uc011jys.1_Missense_Mutation_p.E84K|KLHL7_uc011jyt.1_5'UTR|KLHL7_uc003svt.2_Missense_Mutation_p.E112K|KLHL7_uc011jyv.1_5'UTR	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	160						Golgi apparatus|nucleolus|plasma membrane					0						AGATTGTCCTGAATTGAAAGC	0.328													0	0	0	0.048971	0	67	57										A	23180423	G	A	23180423	3	1	41	1	0	0	0	0	1	0	0	0	8394	1291	45	1	559	1	KLHL7	7	23180423	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2741808	23180423	135958240	124	10542										
BMPER	168667	broad.mit.edu	37	chr7	34192756	34192756	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acctgtggtccgggatgtatCaagacgtgtgacaactggaa	13	8	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:34192756C>G	uc011kap.1	+	15	2043	c.1929C>G	c.(1927-1929)ATC>ATG	p.I643M		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	643	TIL.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CGGGATGTATCAAGACGTGTG	0.507													0	0	0	0.048971	0	55	83										G	34192756	C	G	34192756	3	3	41	1	0	0	0	0	1	0	0	0	1468	816	29	1	1987	1	BMPER	7	34192756	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	11012333	34192756	124945907	125	10543										
CDK13	8621	broad.mit.edu	37	chr7	40134032	40134032	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agcaggagacacttacgtgtCcacttcagactacaaggaca	9	11	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:40134032C>G	uc003thh.3	+	14	4274	c.3992C>G	c.(3991-3993)TCC>TGC	p.S1331C	CDK13_uc003thi.3_Missense_Mutation_p.S1271C|CDK13_uc003thj.2_Missense_Mutation_p.S382C|CDK13_uc003thk.2_Missense_Mutation_p.S264C	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1331					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						ACTTACGTGTCCACTTCAGAC	0.483													0	0	0	0.048971	0	73	52										G	40134032	C	G	40134032	3	3	41	1	0	0	0	0	1	0	0	0	3129	855	30	1	4046	1	CDK13	7	40134032	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	5941276	40134032	119004631	126	10544										
HECW1	23072	broad.mit.edu	37	chr7	43484701	43484701	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccccagcctggccaatggcGcggcccaggatggcgacacg	14	16	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:43484701G>A	uc003tid.1	+	11	2535	c.1930G>A	c.(1930-1932)GCG>ACG	p.A644T	HECW1_uc011kbi.1_Missense_Mutation_p.A644T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	644					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GGCCAATGGCGCGGCCCAGGA	0.711													0	0	0	0.105934	0	10	13										A	43484701	G	A	43484701	3	1	41	1	0	0	0	0	1	0	0	0	7042	1087	38	2	1964	2	HECW1	7	43484701	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3350669	43484701	115653962	127	10545										
PPIA	5478	broad.mit.edu	37	chr7	44839364	44839364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tctatggggagaaatttgaaGatgagaacttcatcctaaag	10	5	2	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:44839364G>A	uc003tlw.2	+	4	336	c.253G>A	c.(253-255)GAT>AAT	p.D85N	PPIA_uc003tlx.2_RNA|PPIA_uc010kyl.2_RNA	NM_021130	NP_066953	P62937	PPIA_HUMAN	peptidylprolyl isomerase A	85	PPIase cyclophilin-type.				entry into host cell|leukocyte migration|platelet activation|platelet degranulation|protein folding|provirus integration|regulation of viral genome replication|RNA-dependent DNA replication|uncoating of virus	cytosol|extracellular region|nucleus	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding|virion binding				0					Cyclosporine(DB00091)|L-Proline(DB00172)	GAAATTTGAAGATGAGAACTT	0.458													0	0	0	0.024245	0	9	252										A	44839364	G	A	44839364	3	1	41	1	0	0	0	0	1	0	0	0	12316	942	33	1	267	1	PPIA	7	44839364	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1354663	44839364	114299299	128	10546										
NSUN5	55695	broad.mit.edu	37	chr7	72721626	72721626	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aacaggtcctcattccggctCacaccccgatgaaccttgag	8	15	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:72721626C>T	uc003txw.2	-	3	381	c.345G>A	c.(343-345)GTG>GTA	p.V115V	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Silent_p.V115V|NSUN5_uc003txx.2_Silent_p.V77V|NSUN5_uc011kev.1_Silent_p.V115V	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	115							methyltransferase activity				0		Lung NSC(55;0.163)				CATTCCGGCTCACACCCCGAT	0.642													0	0	0	0.069234	0	10	29										T	72721626	C	T	72721626	2	4	41	1	0	0	0	0	0	0	0	1	10681	813	29	1		1	NSUN5	7	72721626	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	27882262	72721626	86417037	129	10547										
POM121C	100101267	broad.mit.edu	37	chr7	75048154	75048154	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtcttggatcccgcaccaatGgaaaatgaaggggccgccga	13	11	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:75048154G>C	uc003udk.3	-	15	3774	c.2889C>G	c.(2887-2889)TCC>TCG	p.S963S		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1205	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						CCGCACCAATGGAAAATGAAG	0.592													0	0	0	0.047766	0	6	26										C	75048154	G	C	75048154	2	2	41	1	0	0	0	0	0	0	0	1	12240	1335	47	4		4	POM121C	7	75048154	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2326528	75048154	84090509	130	10548										
HGF	3082	broad.mit.edu	37	chr7	81388061	81388061	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	attcttttttcactccacttGacatgctattgaaggggaac	7	9	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:81388061G>C	uc003uhl.2	-	3	479	c.314C>G	c.(313-315)TCA>TGA	p.S105*	HGF_uc003uhm.2_Nonsense_Mutation_p.S105*|HGF_uc003uhn.1_Nonsense_Mutation_p.S105*|HGF_uc003uho.1_Nonsense_Mutation_p.S105*|HGF_uc003uhp.2_Nonsense_Mutation_p.S105*	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	105	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						CACTCCACTTGACATGCTATT	0.318													0	0	0	0.080935	0	11	54										C	81388061	G	C	81388061	4	2	41	1	0	0	0	0	0	1	0	0	7085	1294	45	1	1956	1	HGF	7	81388061	Nonsense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6339907	81388061	77750602	131	10549										
AKAP9	10142	broad.mit.edu	37	chr7	91603155	91603155	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgatttgaatattgatcaatCacagtgtaatgaaatgtaca	7	4	2	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:91603155C>T	uc003ulg.2	+	2	404	c.179C>T	c.(178-180)TCA>TTA	p.S60L	AKAP9_uc003uld.3_Missense_Mutation_p.S60L|AKAP9_uc003ule.2_Missense_Mutation_p.S72L|AKAP9_uc003ulf.2_Missense_Mutation_p.S60L	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	72					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATTGATCAATCACAGTGTAAT	0.363			T	BRAF	papillary thyroid								0	0	0	0.062417	0	21	35										T	91603155	C	T	91603155	3	4	41	1	0	0	0	0	1	0	0	0	459	838	29	1	185	1	AKAP9	7	91603155	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	10215094	91603155	67535508	132	10550										
TFPI2	7980	broad.mit.edu	37	chr7	93516176	93516176	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccggattctactggcaaagcGaagctttggcatcttctttt	9	10	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:93516176G>A	uc003umy.1	-	5	739	c.664C>T	c.(664-666)CGC>TGC	p.R222C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_3'UTR|TFPI2_uc003una.1_Missense_Mutation_p.R211C|TFPI2_uc003unb.1_Missense_Mutation_p.R228C|TFPI2_uc010lfg.1_Missense_Mutation_p.R98C	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	222					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			CTGGCAAAGCGAAGCTTTGGC	0.328													0	0	0	0.050027	0	33	85										A	93516176	G	A	93516176	3	1	41	1	0	0	0	0	1	0	0	0	15806	1058	37	1	47	1	TFPI2	7	93516176	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1913021	93516176	65622487	133	10551										
ACN9	57001	broad.mit.edu	37	chr7	96747140	96747140	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccctgggcgaccagtacgtGaaagacgaatttaggagaca	12	9	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:96747140G>A	uc003uoo.3	+	1	1236	c.105G>A	c.(103-105)GTG>GTA	p.V35V		NM_020186	NP_064571	Q9NRP4	ACN9_HUMAN	ACN9 homolog precursor	35					regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					ACCAGTACGTGAAAGACGAAT	0.567													0	0	0	0.043863	0	20	55										A	96747140	G	A	96747140	2	1	41	1	0	0	0	0	0	0	0	1	145	1277	45	1		1	ACN9	7	96747140	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3230964	96747140	62391523	134	10552										
TAF6	6878	broad.mit.edu	37	chr7	99710524	99710524	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggttctgtggcttcagccttCtgttgctctttgggagctgg	14	9	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:99710524C>T	uc003uti.2	-	6	552	c.471G>A	c.(469-471)CAG>CAA	p.Q157Q	TAF6_uc003utg.2_Silent_p.Q79Q|TAF6_uc003uth.2_Silent_p.Q214Q|TAF6_uc003utk.2_Silent_p.Q157Q|TAF6_uc011kji.1_Silent_p.Q194Q|TAF6_uc003utj.2_Silent_p.Q147Q|TAF6_uc003utl.2_Silent_p.Q157Q|TAF6_uc003utm.2_Silent_p.Q157Q|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	157					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTTCAGCCTTCTGTTGCTCTT	0.532													0	0	0	0.048971	0	93	227										T	99710524	C	T	99710524	2	4	41	1	0	0	0	0	0	0	0	1	15527	912	32	1		1	TAF6	7	99710524	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2963384	99710524	59428139	135	10553										
RELN	5649	broad.mit.edu	37	chr7	103183210	103183210	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaatccaggtctcgtgtcatCaacatgcgcaagccatcttc	7	13	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:103183210C>G	uc003vca.2	-	43	6799	c.6639G>C	c.(6637-6639)TTG>TTC	p.L2213F	RELN_uc010liz.2_Missense_Mutation_p.L2213F	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2213					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTCGTGTCATCAACATGCGCA	0.363													0	0	0	0.083992	0	22	70										G	103183210	C	G	103183210	3	3	41	1	0	0	0	0	1	0	0	0	13220	825	29	1	3835	1	RELN	7	103183210	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3472686	103183210	55955453	136	10554										
NUP205	23165	broad.mit.edu	37	chr7	135261759	135261759	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acacgctttacagatgagctGatggagcaaggattgactta	11	7	0	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:135261759G>C	uc003vsw.2	+	5	562	c.531G>C	c.(529-531)CTG>CTC	p.L177L	NUP205_uc011kqa.1_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	177					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CAGATGAGCTGATGGAGCAAG	0.388													0	0	0	0.09319	0	12	23										C	135261759	G	C	135261759	2	2	41	1	0	0	0	0	0	0	0	1	10759	1277	45	1		1	NUP205	7	135261759	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	32078549	135261759	23876904	137	10555										
NUP205	23165	broad.mit.edu	37	chr7	135263632	135263632	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttgcctgggcgctggcattGaggggaatatcccagctacc	13	12	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:135263632G>A	uc003vsw.2	+	7	1042	c.1011G>A	c.(1009-1011)TTG>TTA	p.L337L	NUP205_uc011kqa.1_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	337					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CGCTGGCATTGAGGGGAATAT	0.448													0	0	0	0.024245	0	12	32										A	135263632	G	A	135263632	2	1	41	1	0	0	0	0	0	0	0	1	10759	1281	45	1		1	NUP205	7	135263632	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1873	135263632	23875031	138	10556										
NUP205	23165	broad.mit.edu	37	chr7	135302356	135302356	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcctaattatccagcttcttCatagggttcttgtagctgaa	7	9	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:135302356C>T	uc003vsw.2	+	27	3728	c.3697C>T	c.(3697-3699)CAT>TAT	p.H1233Y	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1233					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CCAGCTTCTTCATAGGGTTCT	0.403													0	0	0	0.105934	0	14	51										T	135302356	C	T	135302356	3	4	41	1	0	0	0	0	1	0	0	0	10759	826	29	1	3803	1	NUP205	7	135302356	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	38724	135302356	23836307	139	10557										
ZNF786	136051	broad.mit.edu	37	chr7	148769075	148769075	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttccggaaggggcccctcccCgtgtgggccgccagatggcg	16	15	0	1	rs35396902		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:148769075C>T	uc003wfh.2	-	4	926	c.789G>A	c.(787-789)ACG>ACA	p.T263T	ZNF786_uc011kuk.1_Silent_p.T226T|ZNF786_uc003wfi.2_Silent_p.T177T	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GGCCCCTCCCCGTGTGGGCCG	0.682													0	0	0	0.028581	0	12	27										T	148769075	C	T	148769075	2	4	41	1	0	0	0	0	0	0	0	1	18155	639	23	2		2	ZNF786	7	148769075	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	13466719	148769075	10369588	140	10558										
GIMAP2	26157	broad.mit.edu	37	chr7	150390122	150390122	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttataaagtacatggaaactCaaagaagttacacagccttg	7	7	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr7:150390122C>T	uc003who.2	+	3	836	c.748C>T	c.(748-750)CAA>TAA	p.Q250*	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	250						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATGGAAACTCAAAGAAGTTA	0.383													0	0	0	0.099896	0	28	30										T	150390122	C	T	150390122	4	4	41	1	0	0	0	0	0	1	0	0	6380	827	29	1	754	1	GIMAP2	7	150390122	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1621047	150390122	8748541	141	10559										
RP1L1	94137	broad.mit.edu	37	chr8	10468223	10468223	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aggagacccaaggtcttcctCaaataactgcagactggcca	9	12	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:10468223C>G	uc003wtc.2	-	4	3614	c.3385G>C	c.(3385-3387)GAG>CAG	p.E1129Q		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1129					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGTCTTCCTCAAATAACTGC	0.602													0	0	0	0.048971	0	56	41										G	10468223	C	G	10468223	3	3	41	1	0	0	0	0	1	0	0	0	13533	835	29	1	3821	1	RP1L1	8	10468223	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		10468223	135895799	142	10560										
PDLIM2	64236	broad.mit.edu	37	chr8	22442667	22442667	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctcactggagaggcagccatCagccgcaggtgagtgtgcct	14	12	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:22442667C>T	uc003xby.2	+	5	853	c.453C>T	c.(451-453)ATC>ATT	p.I151I	PDLIM2_uc003xbx.1_Silent_p.I151I|PDLIM2_uc003xbz.2_Silent_p.I151I|PDLIM2_uc003xca.2_Silent_p.I151I|PDLIM2_uc003xcb.2_Silent_p.I151I|PDLIM2_uc003xcc.1_Silent_p.I151I	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	151	Ser-rich.					actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		AGGCAGCCATCAGCCGCAGGT	0.662													0	0	0	0.11126	0	26	21										T	22442667	C	T	22442667	2	4	41	1	0	0	0	0	0	0	0	1	11680	816	29	1		1	PDLIM2	8	22442667	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	11974444	22442667	123921355	143	10561										
ST18	9705	broad.mit.edu	37	chr8	53084883	53084883	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaagggtggctgagaatcatCaatcttgtctcttccatcat	9	9	5	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:53084883C>T	uc003xqz.2	-	5	694	c.538G>A	c.(538-540)GAT>AAT	p.D180N	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.D145N|ST18_uc011lds.1_Missense_Mutation_p.D85N|ST18_uc003xra.2_Missense_Mutation_p.D180N|ST18_uc003xrb.2_Missense_Mutation_p.D180N	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	180						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGAGAATCATCAATCTTGTCT	0.428													0	0	0	0.048971	0	55	100										T	53084883	C	T	53084883	3	4	41	1	0	0	0	0	1	0	0	0	15211	826	29	1	2673	1	ST18	8	53084883	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	30642216	53084883	93279139	144	10562										
ST18	9705	broad.mit.edu	37	chr8	53084982	53084982	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccactgtcatttaaattttCacttacagtctgaacagata	5	9	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:53084982C>T	uc003xqz.2	-	5	595	c.439G>A	c.(439-441)GAA>AAA	p.E147K	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.E112K|ST18_uc011lds.1_Missense_Mutation_p.E52K|ST18_uc003xra.2_Missense_Mutation_p.E147K|ST18_uc003xrb.2_Missense_Mutation_p.E147K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	147						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTTAAATTTTCACTTACAGTC	0.378													0	0	0	0.048971	0	64	103										T	53084982	C	T	53084982	3	4	41	1	0	0	0	0	1	0	0	0	15211	835	29	1	2772	1	ST18	8	53084982	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	99	53084982	93279040	145	10563										
PDE7A	5150	broad.mit.edu	37	chr8	66659966	66659966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cacgaaaaaagcgtgaagatCtaagatatcgctggaaactt	9	7	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:66659966C>G	uc003xvq.2	-	4	368	c.356G>C	c.(355-357)AGA>ACA	p.R119T	PDE7A_uc003xvr.2_Missense_Mutation_p.R119T|PDE7A_uc003xvp.2_Missense_Mutation_p.R93T	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	119						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GCGTGAAGATCTAAGATATCG	0.343													0	0	0	0.020292	0	15	33										G	66659966	C	G	66659966	3	3	41	1	0	0	0	0	1	0	0	0	11651	913	32	1	1164	1	PDE7A	8	66659966	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	13574984	66659966	79704056	146	10564										
PREX2	80243	broad.mit.edu	37	chr8	68981310	68981310	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	accagaacagatgttatataGatttcgctatgatgatggaa	9	5	0	5			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:68981310G>C	uc003xxv.1	+	12	1409	c.1382G>C	c.(1381-1383)AGA>ACA	p.R461T	PREX2_uc003xxu.1_Missense_Mutation_p.R461T|PREX2_uc011lez.1_Missense_Mutation_p.R396T	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	461	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ATGTTATATAGATTTCGCTAT	0.348													0	0	0	0.0918	0	24	46										C	68981310	G	C	68981310	3	2	41	1	0	0	0	0	1	0	0	0	12477	942	33	1	1428	1	PREX2	8	68981310	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2321344	68981310	77382712	147	10565										
WWP1	11059	broad.mit.edu	37	chr8	87439902	87439902	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agagttgatgatcgtagaagAgtttattatgtggatcataa	11	2	1	5			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:87439902A>T	uc003ydt.2	+	11	1468	c.1188A>T	c.(1186-1188)AGA>AGT	p.R396S	WWP1_uc010mai.2_Missense_Mutation_p.R172S	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	396	WW 2.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						ATCGTAGAAGAGTTTATTATG	0.373													0	0	0	0.048971	0	55	125										T	87439902	A	T	87439902	3	4	41	1	0	0	0	0	1	0	0	0	17412	301	11	5	1222	5	WWP1	8	87439902	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	18458592	87439902	58924120	148	10566										
FZD6	8323	broad.mit.edu	37	chr8	104337581	104337581	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	actaaagaaatttatgattcGaattggagtcttcagcggct	9	6	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:104337581G>A	uc003ylh.2	+	4	1531	c.1247G>A	c.(1246-1248)CGA>CAA	p.R416Q	FZD6_uc003yli.2_Missense_Mutation_p.R416Q|FZD6_uc003ylj.2_Missense_Mutation_p.R416Q|FZD6_uc011lhn.1_Missense_Mutation_p.R382Q|FZD6_uc011lho.1_Missense_Mutation_p.R111Q|FZD6_uc011lhp.1_Missense_Mutation_p.R361Q	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	416	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			TTTATGATTCGAATTGGAGTC	0.403													0	0	0	0.083992	0	18	88										A	104337581	G	A	104337581	3	1	41	1	0	0	0	0	1	0	0	0	6134	1058	37	1	1257	1	FZD6	8	104337581	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	16897679	104337581	42026441	149	10567										
ZHX2	22882	broad.mit.edu	37	chr8	123964977	123964977	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	catggccagaagagacccttGgtgactccccaagctgcccc	10	16	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:123964977G>C	uc003ypk.1	+	3	1794	c.1227G>C	c.(1225-1227)TTG>TTC	p.L409F		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	409	Required for interaction with NFYA.|Required for repressor activity.|Required for nuclear localization.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AGAGACCCTTGGTGACTCCCC	0.637													0	0	0	0.004672	0	3	54										C	123964977	G	C	123964977	3	2	41	1	0	0	0	0	1	0	0	0	17673	1339	47	4	1229	4	ZHX2	8	123964977	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	19627396	123964977	22399045	150	10568										
ATAD2	29028	broad.mit.edu	37	chr8	124335198	124335198	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgaataagtgatgttttatCatggtccttgcgatgccgat	10	7	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:124335198C>A	uc003yqh.3	-	27	4219	c.4111G>T	c.(4111-4113)GAT>TAT	p.D1371Y	ATAD2_uc011lii.1_Missense_Mutation_p.D1162Y|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GATGTTTTATCATGGTCCTTG	0.333													1	0	4.57574e-12	0.048971	4.77418e-12	61	116										A	124335198	C	A	124335198	3	1	41	1	0	0	0	0	1	0	0	0	1071	826	29	3	69	3	ATAD2	8	124335198	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	370221	124335198	22028824	151	10569										
ATAD2	29028	broad.mit.edu	37	chr8	124346190	124346190	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctctgggtctgatcttttatCaccaacaagagtggaatttt	8	8	4	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:124346190C>T	uc003yqh.3	-	24	3514	c.3406G>A	c.(3406-3408)GAT>AAT	p.D1136N	ATAD2_uc011lii.1_Missense_Mutation_p.D927N|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GATCTTTTATCACCAACAAGA	0.413													0	0	0	0.083992	0	25	113										T	124346190	C	T	124346190	3	4	41	1	0	0	0	0	1	0	0	0	1071	826	29	1	786	1	ATAD2	8	124346190	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	10992	124346190	22017832	152	10570										
MTSS1	9788	broad.mit.edu	37	chr8	125568500	125568500	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcagccgatacagtcatgctCcgtggtctctgagcctcctc	10	15	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:125568500C>T	uc003yrk.2	-	12	1911	c.1377G>A	c.(1375-1377)CGG>CGA	p.R459R	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_5'UTR|MTSS1_uc011lin.1_Silent_p.R233R|MTSS1_uc011lio.1_Silent_p.R349R|MTSS1_uc003yri.2_Silent_p.R177R|MTSS1_uc003yrj.2_Silent_p.R434R|MTSS1_uc003yrl.2_Silent_p.R463R	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	459					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CAGTCATGCTCCGTGGTCTCT	0.632													0	0	0	0.080935	0	9	22										T	125568500	C	T	125568500	2	4	41	1	0	0	0	0	0	0	0	1	9962	842	30	1		1	MTSS1	8	125568500	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1222310	125568500	20795522	153	10571										
NSMCE2	286053	broad.mit.edu	37	chr8	126114679	126114679	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttccaagcctgtatcaactCtggtatggacacagcttcta	7	12	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:126114679C>G	uc003yrw.2	+	3	335	c.107C>G	c.(106-108)TCT>TGT	p.S36C	NSMCE2_uc003yrv.2_Missense_Mutation_p.S36C	NM_173685	NP_775956	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog	36					DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)	1	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			TGTATCAACTCTGGTATGGAC	0.418													0	0	0	0.099896	0	20	138										G	126114679	C	G	126114679	3	3	41	1	0	0	0	0	1	0	0	0	10676	913	32	1	109	1	NSMCE2	8	126114679	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	546179	126114679	20249343	154	10572										
NSMCE2	286053	broad.mit.edu	37	chr8	126114697	126114697	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctctggtatggacacagcttCtagtgttgctttggatcttg	11	8	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:126114697C>T	uc003yrw.2	+	3	353	c.125C>T	c.(124-126)TCT>TTT	p.S42F	NSMCE2_uc003yrv.2_Missense_Mutation_p.S42F	NM_173685	NP_775956	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog	42					DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)	1	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			GACACAGCTTCTAGTGTTGCT	0.423													0	0	0	0.076483	0	22	141										T	126114697	C	T	126114697	3	4	41	1	0	0	0	0	1	0	0	0	10676	913	32	1	127	1	NSMCE2	8	126114697	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	18	126114697	20249325	155	10573										
FAM135B	51059	broad.mit.edu	37	chr8	139380150	139380150	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaattgtaaagcatacttacCctctctgaaagagatccaca	5	10	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:139380150C>T	uc003yuy.2	-	2	248	c.77G>A	c.(76-78)GGG>GAG	p.G26E	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	26										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCATACTTACCCTCTCTGAAA	0.328										HNSCC(54;0.14)			0	0	0	0.038147	0	7	88										T	139380150	C	T	139380150	3	4	41	1	0	0	0	0	1	0	0	0	5449	637	22	2	4219	2	FAM135B	8	139380150	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	13265453	139380150	6983872	156	10574										
ARHGAP39	80728	broad.mit.edu	37	chr8	145806415	145806415	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggggactccgtgttctgcttCagcgtctgcagcttggccag	14	12	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr8:145806415C>T	uc003zdt.1	-	4	882	c.327G>A	c.(325-327)CTG>CTA	p.L109L	ARHGAP39_uc011llk.1_Silent_p.L109L|ARHGAP39_uc003zds.1_Silent_p.L109L	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	109					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						TGTTCTGCTTCAGCGTCTGCA	0.701													0	0	0	0.038147	0	8	3										T	145806415	C	T	145806415	2	4	41	1	0	0	0	0	0	0	0	1	884	813	29	1		1	ARHGAP39	8	145806415	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6426265	145806415	557607	157	10575										
SMARCA2	6595	broad.mit.edu	37	chr9	2110409	2110409	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tctttgacagcgactggaatCctcatcaggtctgcatgtcc	9	12	4	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:2110409C>T	uc003zhc.2	+	24	3547	c.3448C>T	c.(3448-3450)CCT>TCT	p.P1150S	SMARCA2_uc003zhd.2_Missense_Mutation_p.P1150S|SMARCA2_uc010mha.2_Missense_Mutation_p.P1083S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1150	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CGACTGGAATCCTCATCAGGT	0.478													0	0	0	0.043863	0	20	8										T	2110409	C	T	2110409	3	4	41	1	0	0	0	0	1	0	0	0	14769	855	30	1	3538	1	SMARCA2	9	2110409	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		2110409	139103022	158	10576										
KIAA1797	54914	broad.mit.edu	37	chr9	20874759	20874759	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggatctttcagttcctggctCttgctatctcaaactgttgt	8	10	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:20874759C>G	uc003zog.1	+	21	2633	c.2270C>G	c.(2269-2271)TCT>TGT	p.S757C	KIAA1797_uc003zoh.1_Missense_Mutation_p.S193C	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	757						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GTTCCTGGCTCTTGCTATCTC	0.408													0	0	0	0.062417	0	23	22										G	20874759	C	G	20874759	3	3	41	1	0	0	0	0	1	0	0	0	8258	913	32	1	2340	1	KIAA1797	9	20874759	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	18764350	20874759	120338672	159	10577										
UNC13B	10497	broad.mit.edu	37	chr9	35386232	35386232	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtgaaggcctgtttgaactCcacatatgaatatatcttca	7	8	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:35386232C>T	uc003zwq.2	+	23	3081	c.2789C>T	c.(2788-2790)TCC>TTC	p.S930F	UNC13B_uc003zwr.2_Missense_Mutation_p.S930F	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	930					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TGTTTGAACTCCACATATGAA	0.493													0	0	0	0.099896	0	27	16										T	35386232	C	T	35386232	3	4	41	1	0	0	0	0	1	0	0	0	16982	855	30	1	2879	1	UNC13B	9	35386232	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	14511473	35386232	105827199	160	10578										
GDA	9615	broad.mit.edu	37	chr9	74764526	74764526	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cacatcttccgagggacgttCgtccactccacctggacctg	9	16	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:74764526C>T	uc004aiq.2	+	1	234	c.51C>T	c.(49-51)TTC>TTT	p.F17F	GDA_uc011lse.1_Intron|GDA_uc011lsf.1_5'UTR|GDA_uc004air.2_Silent_p.F17F|GDA_uc010mow.1_RNA|GDA_uc004ais.2_5'UTR	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	17					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GAGGGACGTTCGTCCACTCCA	0.697													0	0	0	0.02938	0	6	8										T	74764526	C	T	74764526	2	4	41	1	0	0	0	0	0	0	0	1	6306	883	31	1		1	GDA	9	74764526	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	39378294	74764526	66448905	161	10579										
STOM	2040	broad.mit.edu	37	chr9	124110421	124110421	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggcatcagtggcatcatccaGagtagactgttaggaagaga	13	7	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:124110421G>C	uc004blh.2	-	6	612	c.532C>G	c.(532-534)CTG>GTG	p.L178V	STOM_uc011lyk.1_Missense_Mutation_p.L127V|STOM_uc004bli.2_Intron	NM_004099	NP_004090	P27105	STOM_HUMAN	stomatin isoform a	178	Cytoplasmic (Potential).				protein homooligomerization	cytoskeleton|integral to plasma membrane|melanosome|membrane raft	protein binding				0				OV - Ovarian serous cystadenocarcinoma(323;0.00107)|GBM - Glioblastoma multiforme(294;0.0137)		GCATCATCCAGAGTAGACTGT	0.502													0	0	0	0.09836	0	39	21										C	124110421	G	C	124110421	3	2	41	1	0	0	0	0	1	0	0	0	15311	933	33	1	342	1	STOM	9	124110421	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	49345895	124110421	17103010	162	10580										
VAV2	7410	broad.mit.edu	37	chr9	136804249	136804249	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccaaagtctcgcacatcgaaGaggtcaaaggggtcaaacag	11	10	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:136804249G>T	uc004ces.2	-	2	343	c.297C>A	c.(295-297)CTC>CTA	p.L99L	VAV2_uc004cer.2_Silent_p.L99L	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	99	CH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GCACATCGAAGAGGTCAAAGG	0.532													1	0	2.24059e-21	0.030593	2.3741e-21	30	107										T	136804249	G	T	136804249	2	4	41	1	0	0	0	0	0	0	0	1	17129	929	33	3		3	VAV2	9	136804249	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	12693828	136804249	4409182	163	10581										
COL5A1	1289	broad.mit.edu	37	chr9	137593102	137593102	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agaccaccaaattcctcgacCgcagcgaccaccccatgatc	6	18	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:137593102C>T	uc004cfe.2	+	4	959	c.577C>T	c.(577-579)CGC>TGC	p.R193C		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	193	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATTCCTCGACCGCAGCGACCA	0.517													0	0	0	0.099896	0	25	28										T	137593102	C	T	137593102	3	4	41	1	0	0	0	0	1	0	0	0	3696	652	23	2	591	2	COL5A1	9	137593102	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	788853	137593102	3620329	164	10582										
KCNT1	57582	broad.mit.edu	37	chr9	138645821	138645821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaactactccttcaatgactCgtcctccgagatcaactggt	7	13	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:138645821C>T	uc011mdq.1	+	5	547	c.473C>T	c.(472-474)TCG>TTG	p.S158L	KCNT1_uc011mdr.1_5'UTR|KCNT1_uc010nbf.2_Missense_Mutation_p.S110L|KCNT1_uc004cgo.1_5'UTR	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	158						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TTCAATGACTCGTCCTCCGAG	0.622													0	0	0	0.034045	0	29	66										T	138645821	C	T	138645821	3	4	41	1	0	0	0	0	1	0	0	0	8091	893	31	1	491	1	KCNT1	9	138645821	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1052719	138645821	2567610	165	10583										
EHMT1	79813	broad.mit.edu	37	chr9	140707937	140707937	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aagtacgtctctcagaactgCgtgacgtcccccatgaacat	8	13	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr9:140707937C>T	uc011mfc.1	+	21	3172	c.3135C>T	c.(3133-3135)TGC>TGT	p.C1045C	EHMT1_uc004coe.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1045					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CTCAGAACTGCGTGACGTCCC	0.582													0	0	0	0.080935	0	10	30										T	140707937	C	T	140707937	2	4	41	1	0	0	0	0	0	0	0	1	4983	776	27	2		2	EHMT1	9	140707937	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2062116	140707937	505494	166	10584										
ADARB2	105	broad.mit.edu	37	chr10	1405328	1405328	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcctgaccccgggccagcttCttgctgcgccccgagccctc	11	20	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:1405328C>G	uc009xhq.2	-	3	1346	c.972G>C	c.(970-972)AAG>AAC	p.K324N		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	324	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GGGCCAGCTTCTTGCTGCGCC	0.721													0	0	0	0.058154	0	9	12										G	1405328	C	G	1405328	3	3	41	1	0	0	0	0	1	0	0	0	283	912	32	1	1279	1	ADARB2	10	1405328	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		1405328	134129419	167	10585										
KIAA1217	56243	broad.mit.edu	37	chr10	24833013	24833013	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gactttgcaagtggtagtctAtgaagaagaggaagaggatg	15	3	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:24833013A>C	uc001iru.3	+	19	5217	c.4814A>C	c.(4813-4815)TAT>TCT	p.Y1605S	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Missense_Mutation_p.Y1288S|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Missense_Mutation_p.Y441S	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1605					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GTGGTAGTCTATGAAGAAGAG	0.468													0	0	0	0.039052	0	40	80										C	24833013	A	C	24833013	3	2	41	1	0	0	0	0	1	0	0	0	8216	449	16	5	4888	5	KIAA1217	10	24833013	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	23427685	24833013	110701734	168	10586										
GPR158	57512	broad.mit.edu	37	chr10	25886754	25886754	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atatataaaagaaagaagatGatcacaaacaacccccacct	4	10	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:25886754G>T	uc001isj.2	+	11	2259	c.2199G>T	c.(2197-2199)ATG>ATT	p.M733I	GPR158_uc001isk.2_Missense_Mutation_p.M108I	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	733	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GAAAGAAGATGATCACAAACA	0.448													1	0	0.000151284	0.105934	0.000153157	14	31										T	25886754	G	T	25886754	3	4	41	1	0	0	0	0	1	0	0	0	6663	1290	45	3	2241	3	GPR158	10	25886754	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1053741	25886754	109647993	169	10587										
EPC1	80314	broad.mit.edu	37	chr10	32635714	32635714	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctcctcttccttctccattcCggtgggcatctgcggcacgg	10	16	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:32635714C>T	uc001iwg.1	-	1	400	c.130G>A	c.(130-132)GGA>AGA	p.G44R	EPC1_uc001iwi.3_Intron|EPC1_uc009xlt.2_Intron|EPC1_uc001iwh.1_Missense_Mutation_p.G44R	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	44					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				TTCTCCATTCCGGTGGGCATC	0.647											OREG0020115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.092188	0	38	79										T	32635714	C	T	32635714	3	4	41	1	0	0	0	0	1	0	0	0	5160	661	23	2	2440	2	EPC1	10	32635714	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6748960	32635714	102899033	170	10588										
FAM21C	253725	broad.mit.edu	37	chr10	46250443	46250443	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgaaggagccacagaagcctGagcagcccactccaaggaaa	11	12	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:46250443G>C	uc001jcu.2	+	15	1399	c.1300G>C	c.(1300-1302)GAG>CAG	p.E434Q	FAM21C_uc001jcs.1_Missense_Mutation_p.E379Q|FAM21C_uc001jct.2_Missense_Mutation_p.E434Q|FAM21C_uc010qfi.1_Missense_Mutation_p.E410Q|FAM21C_uc010qfj.1_5'UTR|FAM21C_uc010qfk.1_5'Flank	NM_015262	NP_056077	A8K5W5	A8K5W5_HUMAN	hypothetical protein LOC253725	434										ovary(1)	1						ACAGAAGCCTGAGCAGCCCAC	0.493													0	0	0	0.024245	0	8	25										C	46250443	G	C	46250443	3	2	41	1	0	0	0	0	1	0	0	0	5542	1291	45	1	1358	1	FAM21C	10	46250443	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	13614729	46250443	89284304	171	10589										
ANK3	288	broad.mit.edu	37	chr10	61830487	61830487	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gactggtcgttgttcccattCtgggcaatttcattctgagg	11	9	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:61830487C>G	uc001jky.2	-	37	10344	c.10152G>C	c.(10150-10152)CAG>CAC	p.Q3384H	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3384					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGTTCCCATTCTGGGCAATTT	0.463													0	0	0	0.020292	0	13	41										G	61830487	C	G	61830487	3	3	41	1	0	0	0	0	1	0	0	0	622	912	32	1	3322	1	ANK3	10	61830487	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	15580044	61830487	73704260	172	10590										
ZNF518A	9849	broad.mit.edu	37	chr10	97919969	97919969	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aagaaaagcaacattgcataGaaagtgtaaagaaaaggcaa	9	4	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr10:97919969G>C	uc001klp.2	+	6	4747	c.3890G>C	c.(3889-3891)AGA>ACA	p.R1297T	ZNF518A_uc001klo.1_Missense_Mutation_p.R767T|ZNF518A_uc001klq.2_Missense_Mutation_p.R1297T|ZNF518A_uc001klr.2_Missense_Mutation_p.R1297T	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		ACATTGCATAGAAAGTGTAAA	0.383													0	0	0	0.009096	0	3	6										C	97919969	G	C	97919969	3	2	41	1	0	0	0	0	1	0	0	0	17959	942	33	1	3892	1	ZNF518A	10	97919969	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	36089482	97919969	37614778	173	10591										
MUC5B	727897	broad.mit.edu	37	chr11	1155713	1155713	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtcagcggcccccacgctgaGcagggtcctcatgaaggtgg	15	13	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:1155713G>C	uc009ycr.1	+	5	527	c.401G>C	c.(400-402)AGC>ACC	p.S134T		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCACGCTGAGCAGGGTCCTC	0.637													0	0	0	0.105934	0	12	14										C	1155713	G	C	1155713	3	2	41	1	0	0	0	0	1	0	0	0	9979	986	34	4		4	MUC5B	11	1155713	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		1155713	133850803	174	10592										
OR56A5	390084	broad.mit.edu	37	chr11	5988888	5988888	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ataaggtggtgcaggatgttGagcaggatggggacatccgg	18	5	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:5988888G>C	uc010qzu.1	-	1	837	c.837C>G	c.(835-837)CTC>CTG	p.L279L		NM_001146033	NP_001139505	P0C7T3	O56A5_HUMAN	olfactory receptor, family 56, subfamily A,	279	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	olfactory receptor activity				0						GCAGGATGTTGAGCAGGATGG	0.527													0	0	0	0.009096	0	4	11										C	5988888	G	C	5988888	2	2	41	1	0	0	0	0	0	0	0	1	11136	1277	45	1		1	OR56A5	11	5988888	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4833175	5988888	129017628	175	10593										
CCDC73	493860	broad.mit.edu	37	chr11	32624470	32624470	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atttagttgattcgtaatgaGgctctgccagtcatcatcac	8	9	4	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:32624470G>C	uc001mtv.2	-	18	3171	c.3127C>G	c.(3127-3129)CTC>GTC	p.L1043V		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	1043										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TTCGTAATGAGGCTCTGCCAG	0.368													0	0	0	0.048971	0	48	38										C	32624470	G	C	32624470	3	2	41	1	0	0	0	0	1	0	0	0	2846	1000	35	4	116	4	CCDC73	11	32624470	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	26635582	32624470	102382046	176	10594										
NUP160	23279	broad.mit.edu	37	chr11	47806511	47806511	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccaattaggcagaggcactCcatgagacaagagcttgttg	12	9	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:47806511C>G	uc001ngm.2	-	33	4038	c.3953G>C	c.(3952-3954)GGA>GCA	p.G1318A	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	1318					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						CAGAGGCACTCCATGAGACAA	0.398													0	0	0	0.048971	0	75	54										G	47806511	C	G	47806511	3	3	41	1	0	0	0	0	1	0	0	0	10757	855	30	1	373	1	NUP160	11	47806511	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	15182041	47806511	87200005	177	10595										
OR4A47	403253	broad.mit.edu	37	chr11	48511051	48511051	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agggaggcaaaaagccctctCaacctgcagttcccacatga	9	13	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:48511051C>G	uc010rhx.1	+	1	707	c.707C>G	c.(706-708)TCA>TGA	p.S236*		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	236	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAAGCCCTCTCAACCTGCAGT	0.433													0	0	0	0.105934	0	14	27										G	48511051	C	G	48511051	4	3	41	1	0	0	0	0	0	1	0	0	11042	838	29	1	709	1	OR4A47	11	48511051	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	704540	48511051	86495465	178	10596										
FOLH1	2346	broad.mit.edu	37	chr11	49176030	49176030	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgatacagtggatagccgctGaatttgtttgtttcctacag	10	7	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:49176030G>A	uc001ngy.2	-	16	1899	c.1638C>T	c.(1636-1638)TTC>TTT	p.F546F	FOLH1_uc001ngx.2_5'UTR|FOLH1_uc001ngz.2_Silent_p.F546F|FOLH1_uc009yly.2_Silent_p.F531F|FOLH1_uc009ylz.2_Silent_p.F531F|FOLH1_uc009yma.2_Silent_p.F238F	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	546	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GATAGCCGCTGAATTTGTTTG	0.333													0	0	0	0.009096	0	3	21										A	49176030	G	A	49176030	2	1	41	1	0	0	0	0	0	0	0	1	5979	1281	45	1		1	FOLH1	11	49176030	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	664979	49176030	85830486	179	10597										
OR4C6	219432	broad.mit.edu	37	chr11	55433450	55433450	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	accccatagacaaggcaatgGctgtgtcagactcaatcatc	8	12	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:55433450G>T	uc001nht.3	+	3	1073	c.808G>T	c.(808-810)GCT>TCT	p.A270S	OR4C6_uc010rik.1_Missense_Mutation_p.A270S	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	270	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CAAGGCAATGGCTGTGTCAGA	0.463													1	0	1.3612e-06	0.024245	1.39183e-06	15	9										T	55433450	G	T	55433450	3	4	41	1	0	0	0	0	1	0	0	0	11052	1203	42	4	810	4	OR4C6	11	55433450	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6257420	55433450	79573066	180	10598										
SLC43A3	29015	broad.mit.edu	37	chr11	57193532	57193532	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccttaaagtaatcttcattCttgaagacaaacactagtga	5	8	3	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:57193532C>T	uc001nkg.2	-	3	524	c.114G>A	c.(112-114)AAG>AAA	p.K38K	PRG2_uc001nke.2_5'Flank|SLC43A3_uc001nkh.2_Silent_p.K38K|SLC43A3_uc010rjr.1_Silent_p.K38K|SLC43A3_uc009yme.2_Silent_p.K38K|SLC43A3_uc001nki.2_Silent_p.K38K|SLC43A3_uc009ymf.1_Silent_p.K38K|SLC43A3_uc010rjs.1_Silent_p.K38K|SLC43A3_uc009ymg.1_Silent_p.K38K	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	38					transmembrane transport	integral to membrane		p.K38K(1)		central_nervous_system(1)	1						AATCTTCATTCTTGAAGACAA	0.552													0	0	0	0.048971	0	61	56										T	57193532	C	T	57193532	2	4	41	1	0	0	0	0	0	0	0	1	14634	912	32	1		1	SLC43A3	11	57193532	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1760082	57193532	77812984	181	10599										
OR4D6	219983	broad.mit.edu	37	chr11	59224919	59224919	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcaatcatccaggtaattctGatgcttccattccccttctg	5	13	4	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:59224919G>A	uc010rku.1	+	1	486	c.486G>A	c.(484-486)CTG>CTA	p.L162L		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGGTAATTCTGATGCTTCCAT	0.517													0	0	0	0.09836	0	44	78										A	59224919	G	A	59224919	2	1	41	1	0	0	0	0	0	0	0	1	11058	1277	45	1		1	OR4D6	11	59224919	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2031387	59224919	75781597	182	10600										
C11orf85	283129	broad.mit.edu	37	chr11	64708119	64708119	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgggtttttctttccctattCtgttaaaaagaagaccaaga	7	7	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:64708119C>G	uc001ocb.1	-	8	548	c.474_splice	c.e8-1	p.R158_splice	C11orf85_uc001occ.1_Splice_Site|C11orf85_uc001ocd.1_Splice_Site_p.N102_splice	NM_001037225	NP_001032302	Q3KP22	CK085_HUMAN	hypothetical protein LOC283129												0						TTTCCCTATTCTGTTAAAAAG	0.413													0	0	0	0.048971	0	64	59										G	64708119	C	G	64708119	5	3	41	1	0	0	0	0	0	0	1	0	1668	927	32	1	185	1	C11orf85	11	64708119	Splice_Site	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	5483200	64708119	70298397	183	10601										
SUV420H1	51111	broad.mit.edu	37	chr11	67926623	67926623	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcttttttacgccaactgaaGattttcggttagaagctgta	8	7	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:67926623G>T	uc001onm.1	-	11	1446	c.1190C>A	c.(1189-1191)TCT>TAT	p.S397Y	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.S225Y|SUV420H1_uc009ysf.2_Missense_Mutation_p.S157Y	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GCCAACTGAAGATTTTCGGTT	0.403													1	0	2.89027e-11	0.069288	3.00794e-11	21	51										T	67926623	G	T	67926623	3	4	41	1	0	0	0	0	1	0	0	0	15411	942	33	3	1471	3	SUV420H1	11	67926623	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3218504	67926623	67079893	184	10602										
FOLH1B	219595	broad.mit.edu	37	chr11	89424064	89424064	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgtaggaaacaaacaaattCagcggctatccactgtatca	7	10	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:89424064C>T	uc001pda.2	+	11	1240	c.714C>T	c.(712-714)TTC>TTT	p.F238F		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	238					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						CAAACAAATTCAGCGGCTATC	0.328													0	0	0	0.021553	0	3	31										T	89424064	C	T	89424064	2	4	41	1	0	0	0	0	0	0	0	1	5980	825	29	1		1	FOLH1B	11	89424064	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	21497441	89424064	45582452	185	10603										
AMOTL1	154810	broad.mit.edu	37	chr11	94533316	94533316	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cccttcaagaccaagcaaatGatgtccccagtcagcaagac	7	14	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:94533316G>A	uc001pfb.2	+	3	1130	c.960G>A	c.(958-960)ATG>ATA	p.M320I	AMOTL1_uc001pfc.2_Missense_Mutation_p.M270I	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	320						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCAAGCAAATGATGTCCCCAG	0.602													0	0	0	0.039052	0	45	106										A	94533316	G	A	94533316	3	1	41	1	0	0	0	0	1	0	0	0	583	1290	45	1	970	1	AMOTL1	11	94533316	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5109252	94533316	40473200	186	10604										
TRPC6	7225	broad.mit.edu	37	chr11	101375138	101375138	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggttgctaacctcttgccttCagcaaaagccggatgactga	10	11	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:101375138C>G	uc001pgk.3	-	2	987	c.562G>C	c.(562-564)GAA>CAA	p.E188Q	TRPC6_uc009ywy.2_Missense_Mutation_p.E188Q|TRPC6_uc009ywz.1_Missense_Mutation_p.E188Q	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	188	Cytoplasmic (Potential).|ANK 3.				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CTCTTGCCTTCAGCAAAAGCC	0.458													0	0	0	0.024245	0	16	11										G	101375138	C	G	101375138	3	3	41	1	0	0	0	0	1	0	0	0	16580	835	29	1	2281	1	TRPC6	11	101375138	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6841822	101375138	33631378	187	10605										
PVRL1	5818	broad.mit.edu	37	chr11	119548477	119548477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgggaggcttcccattggctGaggtgcaggtggccaccagg	17	10	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:119548477G>A	uc001pwv.2	-	3	693	c.521C>T	c.(520-522)TCA>TTA	p.S174L	PVRL1_uc001pwu.1_Missense_Mutation_p.S174L|PVRL1_uc001pww.2_Missense_Mutation_p.S174L	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	174	Extracellular (Potential).|Ig-like C2-type 1.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCCATTGGCTGAGGTGCAGGT	0.577													0	0	0	0.09836	0	36	28										A	119548477	G	A	119548477	3	1	41	1	0	0	0	0	1	0	0	0	12839	1294	45	1	1494	1	PVRL1	11	119548477	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	18173339	119548477	15458039	188	10606										
ARHGAP32	9743	broad.mit.edu	37	chr11	128839644	128839644	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atggcggctctcctttccttCtgccactgagagaagtccag	10	13	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr11:128839644C>T	uc009zcp.2	-	22	5422	c.5422G>A	c.(5422-5424)GAA>AAA	p.E1808K	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.E767K|ARHGAP32_uc001qez.2_Missense_Mutation_p.E1459K	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1808	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TCCTTTCCTTCTGCCACTGAG	0.567													0	0	0	0.048971	0	61	32										T	128839644	C	T	128839644	3	4	41	1	0	0	0	0	1	0	0	0	881	922	32	1	845	1	ARHGAP32	11	128839644	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9291167	128839644	6166872	189	10607										
ERC1	23085	broad.mit.edu	37	chr12	1213916	1213916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tttctgcctcttttctacagGagatgcatcgaaggtttgag	10	8	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:1213916G>A	uc001qjb.2	+	4	1328	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.E363K|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_Intron|ERC1_uc001qjf.2_Missense_Mutation_p.E363K|ERC1_uc010sdv.1_Missense_Mutation_p.E139K|ERC1_uc009zdp.2_5'UTR	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	363	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			TTTTCTACAGGAGATGCATCG	0.413													0	0	0	0.041601	0	26	111										A	1213916	G	A	1213916	3	1	41	1	0	0	0	0	1	0	0	0	5210	1188	41	1	1097	1	ERC1	12	1213916	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		1213916	132637979	190	10608										
FOXM1	2305	broad.mit.edu	37	chr12	2975580	2975580	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttaaacacctggtccaatgtCaagtagcggttggcactggg	12	9	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:2975580C>G	uc001qlf.2	-	5	1219	c.954G>C	c.(952-954)TTG>TTC	p.L318F	FOXM1_uc001qle.2_Missense_Mutation_p.L318F|FOXM1_uc001qlg.2_Missense_Mutation_p.L318F|FOXM1_uc009zea.2_Missense_Mutation_p.L317F|FOXM1_uc009zeb.2_Missense_Mutation_p.L317F	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	318	Fork-head.				cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GGTCCAATGTCAAGTAGCGGT	0.507													0	0	0	0.099896	0	25	76										G	2975580	C	G	2975580	3	3	41	1	0	0	0	0	1	0	0	0	6018	825	29	1	1475	1	FOXM1	12	2975580	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1761664	2975580	130876315	191	10609										
CD163L1	283316	broad.mit.edu	37	chr12	7556186	7556186	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	catgttcgctttgcttttccAtcatatgtgcagtcccagag	8	11	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:7556186A>G	uc001qsy.2	-	6	1379	c.1353T>C	c.(1351-1353)GAT>GAC	p.D451D	CD163L1_uc010sge.1_Silent_p.D461D	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	451	SRCR 4.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TTGCTTTTCCATCATATGTGC	0.413													0	0	0	0.014758	0	4	24										G	7556186	A	G	7556186	2	3	41	1	0	0	0	0	0	0	0	1	2968	214	8	5		5	CD163L1	12	7556186	Silent	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	4580606	7556186	126295709	192	10610										
NANOG	79923	broad.mit.edu	37	chr12	7945759	7945759	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gagacagaaatacctcagccTccagcagatgcaagaactct	8	12	2	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:7945759T>A	uc009zfy.1	+	2	581	c.365T>A	c.(364-366)CTC>CAC	p.L122H		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	122	Homeobox.				cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		TACCTCAGCCTCCAGCAGATG	0.443													0	0	0	0.050027	0	30	28										A	7945759	T	A	7945759	3	1	41	1	0	0	0	0	1	0	0	0	10150	1551	54	5	371	5	NANOG	12	7945759	Missense_Mutation	SNP	T	TCGA-DK-A1A5-01A-11D-A13W-08	389573	7945759	125906136	193	10611										
TAS2R50	259296	broad.mit.edu	37	chr12	11139103	11139106	+	Frame_Shift_Del	DEL	AAGA	AAGA	-													0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctaactctcctctttaaatgAagaaaaagaaggttggagaa							TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:11139103_11139106delAAGA	uc001qzl.2	-	1	406_409	c.354_357delTCTT	c.(352-357)TTTCTTfs	p.F118fs	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	118_119	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						TCTTTAAATGAAGAAAAAGAAGGT	0.392																		23	69	---	---								-	11139106	AAGA	-	11139103	7	5	41	1	0	1	0	1	0	0	0	0	15581	233	9	0	546	0	TAS2R50	12	11139103	Frame_Shift_Del	DEL	AAGA	TCGA-DK-A1A5-01A-11D-A13W-08	3193344	11139103	122712792	194	10612										
GPRC5D	55507	broad.mit.edu	37	chr12	13103173	13103173	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggctgcagtcttggatctttCgcatgaggaagagaaatgct	13	7	2	2	rs141265402		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:13103173C>T	uc010shp.1	-	1	146	c.146G>A	c.(145-147)CGA>CAA	p.R49Q		NM_018654	NP_061124	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5,	49	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TTGGATCTTTCGCATGAGGAA	0.552													0	0	0	0.069456	0	37	34										T	13103173	C	T	13103173	3	4	41	1	0	0	0	0	1	0	0	0	6727	884	31	1	901	1	GPRC5D	12	13103173	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1964070	13103173	120748722	195	10613										
ITPR2	3709	broad.mit.edu	37	chr12	26875357	26875357	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccctcgcttctcagtttccaGaacggatgaatataaaacca	6	12	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:26875357G>A	uc001rhg.2	-	5	915	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ITPR2_uc001rhh.1_Silent_p.F104F|ITPR2_uc001rhi.1_Silent_p.F166F	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	166	MIR 1.|Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCAGTTTCCAGAACGGATGAA	0.388													0	0	0	0.058154	0	10	21										A	26875357	G	A	26875357	2	1	41	1	0	0	0	0	0	0	0	1	7921	933	33	1		1	ITPR2	12	26875357	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	13772184	26875357	106976538	196	10614										
KIF21A	55605	broad.mit.edu	37	chr12	39711890	39711890	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttacttatcctgctgaactGatgtgtttccctgagaaaca	7	10	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:39711890G>A	uc001rly.2	-	29	4039	c.3893C>T	c.(3892-3894)TCA>TTA	p.S1298L	KIF21A_uc001rlv.2_Intron|KIF21A_uc001rlw.2_Intron|KIF21A_uc001rlx.2_Missense_Mutation_p.S1285L|KIF21A_uc001rlz.2_Missense_Mutation_p.S1262L|KIF21A_uc010skl.1_Missense_Mutation_p.S1278L|KIF21A_uc001rlu.2_5'UTR	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1298					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CTGCTGAACTGATGTGTTTCC	0.398													0	0	0	0.0333	0	16	96										A	39711890	G	A	39711890	3	1	41	1	0	0	0	0	1	0	0	0	8288	1294	45	1	1171	1	KIF21A	12	39711890	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	12836533	39711890	94140005	197	10615										
TROAP	10024	broad.mit.edu	37	chr12	49723705	49723705	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcactggagggttctgggaaAccaccggtggccactccttc	12	13	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:49723705A>C	uc001rtx.3	+	12	1397	c.1230A>C	c.(1228-1230)AAA>AAC	p.K410N	TROAP_uc009zlh.2_Missense_Mutation_p.K410N|TROAP_uc001rty.2_Missense_Mutation_p.K118N	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	410					cell adhesion	cytoplasm				ovary(1)	1						GTTCTGGGAAACCACCGGTGG	0.552													0	0	0	0.064281	0	11	263										C	49723705	A	C	49723705	3	2	41	1	0	0	0	0	1	0	0	0	16572	40	2	5	1374	5	TROAP	12	49723705	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	10011815	49723705	84128190	198	10616										
KRT71	112802	broad.mit.edu	37	chr12	52940119	52940119	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ataggtggcgatctccatgtCcagggccagcttcaggctca	12	12	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:52940119C>G	uc001sao.2	-	7	1346	c.1276G>C	c.(1276-1278)GAC>CAC	p.D426H		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	426	Coil 2.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		ATCTCCATGTCCAGGGCCAGC	0.667													0	0	0	0.09319	0	12	86										G	52940119	C	G	52940119	3	3	41	1	0	0	0	0	1	0	0	0	8484	855	30	1	307	1	KRT71	12	52940119	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3216414	52940119	80911776	199	10617										
OR6C6	283365	broad.mit.edu	37	chr12	55688666	55688666	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atggcaacgtagcggtcataGgacatggcagccaggaggta	15	8	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:55688666G>A	uc010sph.1	-	1	351	c.351C>T	c.(349-351)TCC>TCT	p.S117S		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	117	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AGCGGTCATAGGACATGGCAG	0.403													0	0	0	0.021553	0	6	11										A	55688666	G	A	55688666	2	1	41	1	0	0	0	0	0	0	0	1	11194	987	35	2		2	OR6C6	12	55688666	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2748547	55688666	78163229	200	10618										
DNAJC14	85406	broad.mit.edu	37	chr12	56188642	56188642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agctcacaggtacattgaatCgttcagccctcttctgcatt	7	12	4	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:56188642C>T	uc001shu.1	-	11	2431	c.2375G>A	c.(2374-2376)CGA>CAA	p.R792Q	SARNP_uc009zoa.2_RNA|SARNP_uc001shs.3_RNA|SARNP_uc001sht.2_Missense_Mutation_p.R109Q|SARNP_uc001shv.3_Missense_Mutation_p.R109Q	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	Error:Variant_position_missing_in_Q6Y2X3_after_alignment					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						TACATTGAATCGTTCAGCCCT	0.428													0	0	0	0.069234	0	11	20										T	56188642	C	T	56188642	3	4	41	1	0	0	0	0	1	0	0	0	4633	884	31	1		1	DNAJC14	12	56188642	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	499976	56188642	77663253	201	10619										
LGR5	8549	broad.mit.edu	37	chr12	71833917	71833917	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cctgtgctgctgcagctggcGaccgggggcagctctcccag	15	15	1	0	rs147257938		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:71833917G>A	uc001swl.2	+	1	105	c.57G>A	c.(55-57)GCG>GCA	p.A19A	TSPAN8_uc001swk.1_Intron|LGR5_uc001swm.2_Silent_p.A19A|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	19						integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TGCAGCTGGCGACCGGGGGCA	0.682													0	0	0	0.076483	0	20	42										A	71833917	G	A	71833917	2	1	41	1	0	0	0	0	0	0	0	1	8757	1045	37	1		1	LGR5	12	71833917	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	15645275	71833917	62017978	202	10620										
BTBD11	121551	broad.mit.edu	37	chr12	108011968	108011968	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaactgctcgcccagccagaGaaggagaagagtgatatcct	11	10	0	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:108011968G>A	uc001tmk.1	+	10	2786	c.2265G>A	c.(2263-2265)GAG>GAA	p.E755E	BTBD11_uc009zut.1_Intron|BTBD11_uc001tmj.2_Silent_p.E755E|BTBD11_uc001tml.1_Silent_p.E292E	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	755	ANK 4.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						CCCAGCCAGAGAAGGAGAAGA	0.597													0	0	0	0.058154	0	9	64										A	108011968	G	A	108011968	2	1	41	1	0	0	0	0	0	0	0	1	1539	933	33	1		1	BTBD11	12	108011968	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	36178051	108011968	25839927	203	10621										
UBE3B	89910	broad.mit.edu	37	chr12	109971290	109971290	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gttcgtgaccagctgctccaGacccccgctcctgggattcg	11	16	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:109971290G>A	uc001top.2	+	27	3545	c.2942G>A	c.(2941-2943)AGA>AAA	p.R981K	UBE3B_uc001toq.2_Missense_Mutation_p.R981K|UBE3B_uc001tos.2_Missense_Mutation_p.R408K|UBE3B_uc001tot.2_Missense_Mutation_p.R99K|UBE3B_uc010sxp.1_Missense_Mutation_p.R99K	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	981	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						AGCTGCTCCAGACCCCCGCTC	0.642													0	0	0	0.048971	0	58	142										A	109971290	G	A	109971290	3	1	41	1	0	0	0	0	1	0	0	0	16877	942	33	1	3040	1	UBE3B	12	109971290	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1959322	109971290	23880605	204	10622										
CIT	11113	broad.mit.edu	37	chr12	120263155	120263155	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atgtaatctggggtcccaatCgggagtttggcattcaccta	11	9	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:120263155C>T	uc001txi.1	-	8	824	c.771G>A	c.(769-771)CCG>CCA	p.P257P	CIT_uc001txj.1_Silent_p.P257P	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	257	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGGTCCCAATCGGGAGTTTGG	0.493													0	0	0	0.092188	0	40	64										T	120263155	C	T	120263155	2	4	41	1	0	0	0	0	0	0	0	1	3438	871	31	1		1	CIT	12	120263155	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	10291865	120263155	13588740	205	10623										
VPS37B	79720	broad.mit.edu	37	chr12	123351840	123351840	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggcacggcctgtcccgaactCatggccgcagtaaacggggt	14	13	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:123351840C>T	uc001udl.2	-	4	784	c.681G>A	c.(679-681)ATG>ATA	p.M227I		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	227	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		GTCCCGAACTCATGGCCGCAG	0.692													0	0	0	0.058154	0	6	12										T	123351840	C	T	123351840	3	4	41	1	0	0	0	0	1	0	0	0	17203	826	29	1	180	1	VPS37B	12	123351840	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3088685	123351840	10500055	206	10624										
TMEM132D	121256	broad.mit.edu	37	chr12	130184379	130184379	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acgtgaagcgatcttcagtgGaatttctggagatggaaaca	12	6	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr12:130184379G>C	uc009zyl.1	-	2	1272	c.944C>G	c.(943-945)TCC>TGC	p.S315C		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	315	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ATCTTCAGTGGAATTTCTGGA	0.493													0	0	0	0.0918	0	23	80										C	130184379	G	C	130184379	3	2	41	1	0	0	0	0	1	0	0	0	16044	1174	41	1	2387	1	TMEM132D	12	130184379	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6832539	130184379	3667516	207	10625										
FLT3	2322	broad.mit.edu	37	chr13	28589746	28589746	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccaagtgagaagatttcccaCagtaatattccatatgacca	6	10	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr13:28589746C>T	uc001urw.2	-	21	2716	c.2634G>A	c.(2632-2634)CTG>CTA	p.L878L	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Silent_p.L837L	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	878	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGATTTCCCACAGTAATATTC	0.552			Mis|O		AML|ALL								0	0	0	0.024245	0	14	93										T	28589746	C	T	28589746	2	4	41	1	0	0	0	0	0	0	0	1	5942	465	17	2		2	FLT3	13	28589746	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		28589746	86580132	208	10626										
BRCA2	675	broad.mit.edu	37	chr13	32914733	32914733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acaaagttaagggagtgttaGaggaatttgatttaatcaga	11	2	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr13:32914733G>C	uc001uub.1	+	11	6468	c.6241G>C	c.(6241-6243)GAG>CAG	p.E2081Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2081	BRCA2 8.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGGAGTGTTAGAGGAATTTGA	0.353			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.048971	0	56	71										C	32914733	G	C	32914733	3	2	41	1	0	0	0	0	1	0	0	0	1499	943	33	1	6279	1	BRCA2	13	32914733	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4324987	32914733	82255145	209	10627										
SLC25A15	10166	broad.mit.edu	37	chr13	41379289	41379289	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agccgccggttccttcgcctCtgcctttgctgcactggtgc	11	16	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr13:41379289C>A	uc001uxn.2	+	4	672	c.350C>A	c.(349-351)TCT>TAT	p.S117Y	SUGT1L1_uc001uxp.1_Intron|SLC25A15_uc010tfb.1_Missense_Mutation_p.S23Y|SUGT1L1_uc001uxo.1_RNA	NM_014252	NP_055067	Q9Y619	ORNT1_HUMAN	mitochondrial ornithine transporter 1	117	Helical; Name=3; (Potential).|Solcar 2.				cellular amino acid metabolic process|mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity				0		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.48e-08)|Epithelial(112;7.51e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000191)|GBM - Glioblastoma multiforme(144;0.00231)|BRCA - Breast invasive adenocarcinoma(63;0.0704)	L-Ornithine(DB00129)	TCCTTCGCCTCTGCCTTTGCT	0.552													1	0	9.57592e-29	0.048971	1.01729e-28	31	36										A	41379289	C	A	41379289	3	1	41	1	0	0	0	0	1	0	0	0	14477	913	32	3	360	3	SLC25A15	13	41379289	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	8464556	41379289	73790589	210	10628										
PIBF1	10464	broad.mit.edu	37	chr13	73590051	73590051	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tctaagaaacaaaagatgaaGacctagtgttttggatggga	11	4	1	4			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr13:73590051G>C	uc001vjc.2	+	18	2573	c.2268G>C	c.(2266-2268)AAG>AAC	p.K756N	PIBF1_uc010aep.2_Missense_Mutation_p.K215N	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	756						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		AAAAGATGAAGACCTAGTGTT	0.348													0	0	0	0.105934	0	11	45										C	73590051	G	C	73590051	3	2	41	1	0	0	0	0	1	0	0	0	11879	933	33	1	2334	1	PIBF1	13	73590051	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	32210762	73590051	41579827	211	10629										
COL4A1	1282	broad.mit.edu	37	chr13	110829360	110829360	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagggtctcccctgggtcctGaggagcccggaaagccatgg	15	13	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr13:110829360G>A	uc001vqw.3	-	34	2863	c.2741C>T	c.(2740-2742)TCA>TTA	p.S914L	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	914	Triple-helical region.			S -> K (in Ref. 8; AA sequence).	angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGGGTCCTGAGGAGCCCGG	0.587													0	0	0	0.0333	0	18	58										A	110829360	G	A	110829360	3	1	41	1	0	0	0	0	1	0	0	0	3689	1294	45	1	2344	1	COL4A1	13	110829360	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	37239309	110829360	4340518	212	10630										
RPGRIP1	57096	broad.mit.edu	37	chr14	21762864	21762864	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atgaaaactcaaccacccttGagcaggatgaaccgggagga	11	10	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:21762864G>C	uc001wag.2	+	2	114	c.114G>C	c.(112-114)TTG>TTC	p.L38F		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	38					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AACCACCCTTGAGCAGGATGA	0.413													0	0	0	0.034045	0	25	38										C	21762864	G	C	21762864	3	2	41	1	0	0	0	0	1	0	0	0	13549	1281	45	1	120	1	RPGRIP1	14	21762864	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		21762864	85586676	213	10631										
HECTD1	25831	broad.mit.edu	37	chr14	31614067	31614067	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aactgagttgctatgtttctGagtgttaccactactccacg	8	10	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:31614067G>C	uc001wrc.1	-	16	3066	c.2577C>G	c.(2575-2577)CTC>CTG	p.L859L	HECTD1_uc001wrd.1_Silent_p.L374L	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	859					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTATGTTTCTGAGTGTTACCA	0.358													0	0	0	0.083992	0	24	21										C	31614067	G	C	31614067	2	2	41	1	0	0	0	0	0	0	0	1	7039	1277	45	1		1	HECTD1	14	31614067	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	9851203	31614067	75735473	214	10632										
NID2	22795	broad.mit.edu	37	chr14	52535556	52535556	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caccacggctgagctttcgtCgtcgccttcctgcaggagct	11	15	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:52535556C>G	uc001wzo.2	-	1	391	c.157G>C	c.(157-159)GAC>CAC	p.D53H	NID2_uc010tqs.1_Missense_Mutation_p.D53H|NID2_uc010tqt.1_Missense_Mutation_p.D53H|NID2_uc001wzp.2_Missense_Mutation_p.D53H	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	53						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GAGCTTTCGTCGTCGCCTTCC	0.627													0	0	0	0.099896	0	26	21										G	52535556	C	G	52535556	3	3	41	1	0	0	0	0	1	0	0	0	10415	884	31	1	4058	1	NID2	14	52535556	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	20921489	52535556	54813984	215	10633										
KIAA0586	9786	broad.mit.edu	37	chr14	58949408	58949408	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aggtgtttctggggatgcttCaacaaatgaaacatatttgc	10	6	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:58949408C>G	uc001xdv.3	+	20	3167	c.2894C>G	c.(2893-2895)TCA>TGA	p.S965*	KIAA0586_uc010trr.1_Nonsense_Mutation_p.S1082*|KIAA0586_uc001xdt.3_Nonsense_Mutation_p.S997*|KIAA0586_uc001xdu.3_Nonsense_Mutation_p.S1026*|KIAA0586_uc010trs.1_Nonsense_Mutation_p.S956*|KIAA0586_uc010trt.1_Nonsense_Mutation_p.S901*|KIAA0586_uc010tru.1_Nonsense_Mutation_p.S901*	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	965										ovary(1)	1						GGGGATGCTTCAACAAATGAA	0.388													0	0	0	0.043863	0	19	39										G	58949408	C	G	58949408	4	3	41	1	0	0	0	0	0	1	0	0	8186	838	29	1	2972	1	KIAA0586	14	58949408	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6413852	58949408	48400132	216	10634										
SIX4	51804	broad.mit.edu	37	chr14	61190738	61190738	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggcgctttccatcccattctCttgcttgatgtccgccgcac	8	16	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:61190738C>G	uc001xfc.2	-	1	55	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	SIX4_uc010app.1_Missense_Mutation_p.E11Q	NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	19						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		ATCCCATTCTCTTGCTTGATG	0.532													0	0	0	0.048971	0	41	62										G	61190738	C	G	61190738	3	3	41	1	0	0	0	0	1	0	0	0	14349	922	32	1	2302	1	SIX4	14	61190738	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2241330	61190738	46158802	217	10635										
KCNH5	27133	broad.mit.edu	37	chr14	63269243	63269243	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggatgttcattaaaaaccttCcggtttagatgaacacagat	8	7	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:63269243C>G	uc001xfx.2	-	9	1677	c.1626G>C	c.(1624-1626)CGG>CGC	p.R542R	KCNH5_uc001xfy.2_Silent_p.R542R|KCNH5_uc001xfz.1_Silent_p.R484R	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	542	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TAAAAACCTTCCGGTTTAGAT	0.493													0	0	0	0.009096	0	4	11										G	63269243	C	G	63269243	2	3	41	1	0	0	0	0	0	0	0	1	8035	842	30	1		1	KCNH5	14	63269243	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2078505	63269243	44080297	218	10636										
SYNE2	23224	broad.mit.edu	37	chr14	64586261	64586261	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaagcgctttccctgaaactGaaaacagtgaagtgcaattt	9	8	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:64586261G>A	uc001xgm.2	+	67	13187	c.12957G>A	c.(12955-12957)CTG>CTA	p.L4319L	SYNE2_uc001xgl.2_Silent_p.L4319L|SYNE2_uc010apy.2_Silent_p.L704L|SYNE2_uc010apz.1_Silent_p.L211L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4319	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCCTGAAACTGAAAACAGTGA	0.428													0	0	0	0.041601	0	32	21										A	64586261	G	A	64586261	2	1	41	1	0	0	0	0	0	0	0	1	15443	1277	45	1		1	SYNE2	14	64586261	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1317018	64586261	42763279	219	10637										
PLEKHH1	57475	broad.mit.edu	37	chr14	68043123	68043123	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctcttccaggatacgtggctCtaccacctcacagtggctgc	9	15	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:68043123C>G	uc001xjl.1	+	17	2506	c.2364C>G	c.(2362-2364)CTC>CTG	p.L788L	PLEKHH1_uc010tsw.1_Silent_p.L356L|PLEKHH1_uc001xjn.1_Silent_p.L303L|PLEKHH1_uc010tsx.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	788	PH 2.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		ATACGTGGCTCTACCACCTCA	0.582													0	0	0	0.043863	0	9	27										G	68043123	C	G	68043123	2	3	41	1	0	0	0	0	0	0	0	1	12076	900	32	1		1	PLEKHH1	14	68043123	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3456862	68043123	39306417	220	10638										
NRXN3	9369	broad.mit.edu	37	chr14	79270112	79270112	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cgacctccagggactctgccGacaccctgcgtctggagctg	12	16	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:79270112G>T	uc001xun.2	+	6	1566	c.1075G>T	c.(1075-1077)GAC>TAC	p.D359Y	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.D493Y	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	732	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGACTCTGCCGACACCCTGCG	0.572													1	0	1.5842e-08	0.105934	1.64035e-08	12	21										T	79270112	G	T	79270112	3	4	41	1	0	0	0	0	1	0	0	0	10667	1058	37	3	1089	3	NRXN3	14	79270112	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	11226989	79270112	28079428	221	10639										
ASB2	51676	broad.mit.edu	37	chr14	94405833	94405833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccaccgcgaagtacagcgcgGagctgcgccggtcttcgtag	14	14	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:94405833G>A	uc001ycc.1	-	6	1583	c.1094C>T	c.(1093-1095)TCC>TTC	p.S365F	ASB2_uc001ycb.1_Missense_Mutation_p.S59F|ASB2_uc001ycd.2_Missense_Mutation_p.S413F|ASB2_uc001yce.1_Missense_Mutation_p.S311F	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	365	ANK 10.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GTACAGCGCGGAGCTGCGCCG	0.687													0	0	0	0.02938	0	6	22										A	94405833	G	A	94405833	3	1	41	1	0	0	0	0	1	0	0	0	1023	1174	41	1	681	1	ASB2	14	94405833	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	15135721	94405833	12943707	222	10640										
ASPG	374569	broad.mit.edu	37	chr14	104570652	104570652	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccccacaggttcgggccttCttgcagcctcccctgaaggg	12	16	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr14:104570652C>G	uc001yoq.1	+	8	825	c.765C>G	c.(763-765)TTC>TTG	p.F255L	ASPG_uc001yoo.1_Missense_Mutation_p.F283L|ASPG_uc001yop.1_Missense_Mutation_p.F255L|ASPG_uc001yor.1_Missense_Mutation_p.F255L	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	255	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						TTCGGGCCTTCTTGCAGCCTC	0.677													0	0	0	0.047766	0	8	23										G	104570652	C	G	104570652	3	3	41	1	0	0	0	0	1	0	0	0	1052	912	32	1	795	1	ASPG	14	104570652	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	10164819	104570652	2778888	223	10641										
TUBGCP5	114791	broad.mit.edu	37	chr15	22864348	22864348	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccaagaagcagtaggacagcGttatcctgaagatagttcac	10	9	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:22864348G>A	uc001yur.3	+	16	2436	c.2306G>A	c.(2305-2307)CGT>CAT	p.R769H	TUBGCP5_uc001yuq.2_Missense_Mutation_p.R769H	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	769					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GTAGGACAGCGTTATCCTGAA	0.289													0	0	0	0.02938	0	6	156										A	22864348	G	A	22864348	3	1	41	1	0	0	0	0	1	0	0	0	16766	1145	40	2	2368	2	TUBGCP5	15	22864348	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		22864348	79667044	224	10642										
TP53BP1	7158	broad.mit.edu	37	chr15	43783886	43783886	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cctgcttgtcctgtttggctGaggtaactgctcaatgacct	10	11	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:43783886G>T	uc001zrs.2	-	4	485	c.337C>A	c.(337-339)CAG>AAG	p.Q113K	TP53BP1_uc010udp.1_Missense_Mutation_p.Q113K|TP53BP1_uc001zrq.3_Missense_Mutation_p.Q118K|TP53BP1_uc001zrr.3_Missense_Mutation_p.Q118K|TP53BP1_uc010udq.1_Missense_Mutation_p.Q118K	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	113					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CTGTTTGGCTGAGGTAACTGC	0.393								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					1	0	6.04909e-70	0.048971	6.51073e-70	169	335										T	43783886	G	T	43783886	3	4	41	1	0	0	0	0	1	0	0	0	16380	1299	45	3	5681	3	TP53BP1	15	43783886	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	20919538	43783886	58747506	225	10643										
B2M	567	broad.mit.edu	37	chr15	45007713	45007713	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtctgggtttcatccatccGacattgaagttgacttactg	9	9	2	2	rs148494241		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:45007713G>A	uc001zuc.2	+	2	220	c.160G>A	c.(160-162)GAC>AAC	p.D54N	B2M_uc010uek.1_Missense_Mutation_p.D54N|B2M_uc010bdx.1_Missense_Mutation_p.D54N	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	54	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TCATCCATCCGACATTGAAGT	0.408													0	0	0	0.048971	0	65	252										A	45007713	G	A	45007713	3	1	41	1	0	0	0	0	1	0	0	0	1244	1058	37	1	166	1	B2M	15	45007713	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1223827	45007713	57523679	226	10644										
MYO1E	4643	broad.mit.edu	37	chr15	59502740	59502740	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttctctatgaggtcacatacGattttattattaaagtactc	5	7	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:59502740G>A	uc002aga.2	-	13	1707	c.1335C>T	c.(1333-1335)ATC>ATT	p.I445I		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	445	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		GGTCACATACGATTTTATTAT	0.348													0	0	0	0.049695	0	19	128										A	59502740	G	A	59502740	2	1	41	1	0	0	0	0	0	0	0	1	10072	1048	37	1		1	MYO1E	15	59502740	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	14495027	59502740	43028652	227	10645										
C15orf59	388135	broad.mit.edu	37	chr15	74032895	74032895	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgcccgccttgtcactgctaGaggtgctgctcacagtggcc	12	14	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:74032895G>C	uc002avy.2	-	2	590	c.245C>G	c.(244-246)TCT>TGT	p.S82C		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	82										pancreas(1)	1						GTCACTGCTAGAGGTGCTGCT	0.587													0	0	0	0.048971	0	84	385										C	74032895	G	C	74032895	3	2	41	1	0	0	0	0	1	0	0	0	1807	942	33	1	640	1	C15orf59	15	74032895	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	14530155	74032895	28498497	228	10646										
PML	5371	broad.mit.edu	37	chr15	74290639	74290639	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cggccgacttctggtgctttGagtgcgagcagctcctctgc	13	13	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:74290639G>C	uc002awv.2	+	2	564	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	PML_uc002awm.2_Missense_Mutation_p.E142Q|PML_uc002awl.2_Missense_Mutation_p.E142Q|PML_uc002awj.1_Missense_Mutation_p.E142Q|PML_uc002awk.2_Missense_Mutation_p.E142Q|PML_uc002awn.2_Missense_Mutation_p.E142Q|PML_uc002awo.2_Missense_Mutation_p.E142Q|PML_uc002awp.2_Missense_Mutation_p.E142Q|PML_uc002awq.2_Missense_Mutation_p.E142Q|PML_uc002awr.2_Missense_Mutation_p.E142Q|PML_uc002aws.2_Missense_Mutation_p.E142Q|PML_uc002awt.2_Missense_Mutation_p.E142Q|PML_uc002awu.2_Missense_Mutation_p.E142Q|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.E57Q	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	142	B box-type 1; atypical.				cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						CTGGTGCTTTGAGTGCGAGCA	0.637			T	RARA|PAX5	APL|ALL								0	0	0	0.080935	0	11	46										C	74290639	G	C	74290639	3	2	41	1	0	0	0	0	1	0	0	0	12135	1291	45	1	430	1	PML	15	74290639	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	257744	74290639	28240753	229	10647										
PTPN9	5780	broad.mit.edu	37	chr15	75798059	75798059	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agggttctcacgacgaatgtCttcatattcctcatagattc	7	10	4	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:75798059C>G	uc002bal.2	-	7	1433	c.925G>C	c.(925-927)GAC>CAC	p.D309H		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	309	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						CGACGAATGTCTTCATATTCC	0.473													0	0	0	0.048971	0	110	209										G	75798059	C	G	75798059	3	3	41	1	0	0	0	0	1	0	0	0	12794	913	32	1	884	1	PTPN9	15	75798059	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1507420	75798059	26733333	230	10648										
RASGRF1	5923	broad.mit.edu	37	chr15	79296180	79296180	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgaagggtcttcgggcttctCaggggtcgtatcgccctcat	13	11	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:79296180C>T	uc002beq.2	-	16	2836	c.2461G>A	c.(2461-2463)GAG>AAG	p.E821K	RASGRF1_uc002bep.2_Missense_Mutation_p.E805K|RASGRF1_uc010blm.1_Missense_Mutation_p.E730K|RASGRF1_uc002ber.3_Missense_Mutation_p.E805K|RASGRF1_uc010unh.1_Missense_Mutation_p.E216K|RASGRF1_uc002beo.2_Missense_Mutation_p.E37K	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	823					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TCGGGCTTCTCAGGGGTCGTA	0.627													0	0	0	0.064281	0	34	43										T	79296180	C	T	79296180	3	4	41	1	0	0	0	0	1	0	0	0	13072	835	29	1	1412	1	RASGRF1	15	79296180	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3498121	79296180	23235212	231	10649										
ALPK3	57538	broad.mit.edu	37	chr15	85401089	85401089	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccctgtacctcccgccgcctCaccggcctcctggaccgtga	9	21	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:85401089C>T	uc002ble.2	+	6	3893	c.3726C>T	c.(3724-3726)CTC>CTT	p.L1242L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1242					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CCCGCCGCCTCACCGGCCTCC	0.692													0	0	0	0.080935	0	8	17										T	85401089	C	T	85401089	2	4	41	1	0	0	0	0	0	0	0	1	546	813	29	1		1	ALPK3	15	85401089	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6104909	85401089	17130303	232	10650										
SYNM	23336	broad.mit.edu	37	chr15	99671728	99671728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcagcccagatgaggaaggtGgagcggaggccccggctgct	18	11	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr15:99671728G>A	uc002bup.2	+	6	3283	c.3163G>A	c.(3163-3165)GGA>AGA	p.G1055R	SYNM_uc002buo.2_Missense_Mutation_p.G1055R|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1055	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TGAGGAAGGTGGAGCGGAGGC	0.652													0	0	0	0.024245	0	12	21										A	99671728	G	A	99671728	3	1	41	1	0	0	0	0	1	0	0	0	15452	1349	47	2	3176	2	SYNM	15	99671728	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	14270639	99671728	2859664	233	10651										
WDR90	197335	broad.mit.edu	37	chr16	703802	703802	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caaggaccaccacgggaggaCggtaacagggccctggctgc	15	13	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:703802C>T	uc002cii.1	+	13	1490	c.1436C>T	c.(1435-1437)ACG>ATG	p.T479M	WDR90_uc002cig.1_Missense_Mutation_p.T479M|WDR90_uc002cih.1_Missense_Mutation_p.T480M|WDR90_uc002cij.1_RNA|WDR90_uc002cik.1_5'Flank|WDR90_uc002cil.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	479	WD 2.									ovary(1)	1		Hepatocellular(780;0.0218)				CACGGGAGGACGGTAACAGGG	0.627													0	0	0	0.058154	0	9	41										T	703802	C	T	703802	3	4	41	1	0	0	0	0	1	0	0	0	17334	550	19	2	1486	2	WDR90	16	703802	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		703802	89650951	234	10652										
PPL	5493	broad.mit.edu	37	chr16	4945714	4945714	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agcgtccttcacgtcttcgtGaaactaggggagaaggtggc	14	9	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:4945714G>A	uc002cyd.1	-	10	1066	c.976C>T	c.(976-978)CAC>TAC	p.H326Y		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	326	Potential.|Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						ACGTCTTCGTGAAACTAGGGG	0.582													0	0	0	0.048971	0	75	98										A	4945714	G	A	4945714	3	1	41	1	0	0	0	0	1	0	0	0	12334	1290	45	1	4346	1	PPL	16	4945714	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4241912	4945714	85409039	235	10653										
ZC3H7A	29066	broad.mit.edu	37	chr16	11868313	11868313	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagctcacttccaacttcatGagaaaaactgggtgccggta	9	11	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:11868313G>A	uc002dbk.2	-	8	880	c.682C>T	c.(682-684)CAT>TAT	p.H228Y	ZC3H7A_uc002dbl.2_Missense_Mutation_p.H228Y|ZC3H7A_uc002dbm.1_Missense_Mutation_p.H228Y	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	228						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						CCAACTTCATGAGAAAAACTG	0.458													0	0	0	0.048971	0	48	69										A	11868313	G	A	11868313	3	1	41	1	0	0	0	0	1	0	0	0	17569	1290	45	1	2293	1	ZC3H7A	16	11868313	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6922599	11868313	78486440	236	10654										
PDILT	204474	broad.mit.edu	37	chr16	20410611	20410611	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	accagcagcaggggcatccaGagtaggtccatggctgtcct	13	12	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:20410611G>A	uc002dhc.1	-	2	235	c.12C>T	c.(10-12)CTC>CTT	p.L4L		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	4					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						GGGGCATCCAGAGTAGGTCCA	0.592													0	0	0	0.083992	0	21	82										A	20410611	G	A	20410611	2	1	41	1	0	0	0	0	0	0	0	1	11674	929	33	1		1	PDILT	16	20410611	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	8542298	20410611	69944142	237	10655										
ACSM5	54988	broad.mit.edu	37	chr16	20430712	20430712	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccagaccaagctgctggtgtCagacagcagtcggccaggct	13	13	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:20430712C>G	uc002dhe.2	+	4	725	c.578C>G	c.(577-579)TCA>TGA	p.S193*	ACSM5_uc002dhd.1_Nonsense_Mutation_p.S193*	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	193					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CTGCTGGTGTCAGACAGCAGT	0.557													0	0	0	0.043863	0	19	27										G	20430712	C	G	20430712	4	3	41	1	0	0	0	0	0	1	0	0	187	838	29	1	588	1	ACSM5	16	20430712	Nonsense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	20101	20430712	69924041	238	10656										
PRKCB	5579	broad.mit.edu	37	chr16	24202490	24202490	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	caaagagcatgcatttttccGgtatattgattgggagaaac	10	6	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:24202490G>A	uc002dmd.2	+	16	1999	c.1802G>A	c.(1801-1803)CGG>CAG	p.R601Q	PRKCB_uc002dme.2_Missense_Mutation_p.R601Q	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	601	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	GCATTTTTCCGGTATATTGAT	0.463													0	0	0	0.009096	0	3	87										A	24202490	G	A	24202490	3	1	41	1	0	0	0	0	1	0	0	0	12508	1116	39	2	1864	2	PRKCB	16	24202490	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3771778	24202490	66152263	239	10657										
TAOK2	9344	broad.mit.edu	37	chr16	29999180	29999180	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acggcccacccgaatcccccGgctactaccacgcagccagc	8	21	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:29999180G>A	uc002dva.1	+	16	4370	c.3587G>A	c.(3586-3588)CGG>CAG	p.R1196Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.R1203Q|TAOK2_uc002dvd.1_Missense_Mutation_p.R1023Q	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	1196					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CGAATCCCCCGGCTACTACCA	0.721													0	0	0	0.014758	0	3	15										A	29999180	G	A	29999180	3	1	41	1	0	0	0	0	1	0	0	0	15545	1116	39	2	3645	2	TAOK2	16	29999180	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5796690	29999180	60355573	240	10658										
SLC12A3	6559	broad.mit.edu	37	chr16	56906612	56906612	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgcctgactggcggggtccaGatggcaccttcttcggaatg	14	11	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:56906612G>C	uc010ccm.2	+	8	1038	c.1009G>C	c.(1009-1011)GAT>CAT	p.D337H	SLC12A3_uc002ekd.3_Missense_Mutation_p.D337H|SLC12A3_uc010ccn.2_Missense_Mutation_p.D336H	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	337					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCGGGGTCCAGATGGCACCTT	0.562													0	0	0	0.11126	0	41	40										C	56906612	G	C	56906612	3	2	41	1	0	0	0	0	1	0	0	0	14384	942	33	1	1039	1	SLC12A3	16	56906612	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	26907432	56906612	33448141	241	10659										
MMP15	4324	broad.mit.edu	37	chr16	58071406	58071406	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggctttatggctacctgcctCagcccagccgccatatgtcc	9	16	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:58071406C>G	uc002ena.2	+	2	1166	c.193C>G	c.(193-195)CAG>GAG	p.Q65E		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	65					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						CTACCTGCCTCAGCCCAGCCG	0.453													0	0	0	0.047766	0	7	15										G	58071406	C	G	58071406	3	3	41	1	0	0	0	0	1	0	0	0	9654	827	29	1	199	1	MMP15	16	58071406	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1164794	58071406	32283347	242	10660										
NDRG4	65009	broad.mit.edu	37	chr16	58537754	58537754	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcatgtagtgatccggggctCccccaaggggaaccgcccag	14	14	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:58537754C>G	uc002eno.2	+	2	180	c.74C>G	c.(73-75)TCC>TGC	p.S25C	NDRG4_uc002enk.2_Missense_Mutation_p.S57C|NDRG4_uc002enm.2_Missense_Mutation_p.S77C|NDRG4_uc010vif.1_Missense_Mutation_p.S57C|NDRG4_uc010cdk.2_Missense_Mutation_p.S25C|NDRG4_uc010vig.1_Missense_Mutation_p.S55C|NDRG4_uc010vih.1_5'UTR|NDRG4_uc010vii.1_Missense_Mutation_p.S43C|NDRG4_uc002enp.2_Missense_Mutation_p.S25C|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	25					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						ATCCGGGGCTCCCCCAAGGGG	0.622													0	0	0	0.080935	0	10	71										G	58537754	C	G	58537754	3	3	41	1	0	0	0	0	1	0	0	0	10254	855	30	1	244	1	NDRG4	16	58537754	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	466348	58537754	31816999	243	10661										
TK2	7084	broad.mit.edu	37	chr16	66584022	66584022	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttgtgcgagtcggcgcggacGactgctagtccagccgttgg	16	11	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:66584022G>C	uc002eos.2	-	1	294	c.69C>G	c.(67-69)GTC>GTG	p.V23V	TK2_uc010vip.1_5'Flank|TK2_uc002eor.2_Intron|TK2_uc010cdq.2_Intron|TK2_uc010cdr.2_5'UTR|TK2_uc010viq.1_Silent_p.V23V|TK2_uc010vir.1_Silent_p.V23V	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial	Error:Variant_position_missing_in_O00142_after_alignment					pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)		CGGCGCGGACGACTGCTAGTC	0.682													0	0	0	0.049695	0	17	16										C	66584022	G	C	66584022	2	2	41	1	0	0	0	0	0	0	0	1	15930	1073	37	1		1	TK2	16	66584022	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	8046268	66584022	23770731	244	10662										
EDC4	23644	broad.mit.edu	37	chr16	67915727	67915727	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccacgtagaacgtgcccttGagactcggcacgagcaggaa	13	12	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:67915727G>C	uc002eur.2	+	22	3149	c.2983G>C	c.(2983-2985)GAG>CAG	p.E995Q	EDC4_uc010cer.2_Missense_Mutation_p.E614Q|EDC4_uc002eus.2_Missense_Mutation_p.E725Q|EDC4_uc002eut.1_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	995	Potential.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		ACGTGCCCTTGAGACTCGGCA	0.602													0	0	0	0.054565	0	33	101										C	67915727	G	C	67915727	3	2	41	1	0	0	0	0	1	0	0	0	4908	1291	45	1	3069	1	EDC4	16	67915727	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1331705	67915727	22439026	245	10663										
CTRL	1506	broad.mit.edu	37	chr16	67964633	67964633	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagcccaggcactcacccgaGagacggacagaacctgcaag	11	15	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:67964633G>A	uc002euw.2	-	4	324	c.314C>T	c.(313-315)TCT>TTT	p.S105F		NM_001907	NP_001898	P40313	CTRL_HUMAN	chymotrypsin-like precursor	105	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		ACTCACCCGAGAGACGGACAG	0.607													0	0	0	0.080422	0	38	147										A	67964633	G	A	67964633	3	1	41	1	0	0	0	0	1	0	0	0	4028	942	33	1	496	1	CTRL	16	67964633	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	48906	67964633	22390120	246	10664										
ZFHX3	463	broad.mit.edu	37	chr16	72923775	72923775	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cgcacatgctggatgaggttGagcttggccttggtggagta	16	7	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:72923775G>C	uc002fck.2	-	4	3976	c.3303C>G	c.(3301-3303)CTC>CTG	p.L1101L	ZFHX3_uc002fcl.2_Silent_p.L187L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1101	C2H2-type 9; atypical.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GGATGAGGTTGAGCTTGGCCT	0.572													0	0	0	0.09319	0	12	119										C	72923775	G	C	72923775	2	2	41	1	0	0	0	0	0	0	0	1	17631	1277	45	1		1	ZFHX3	16	72923775	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4959142	72923775	17430978	247	10665										
PKD1L2	114780	broad.mit.edu	37	chr16	81194452	81194452	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcacccacaaagcttcaggaCtggtcaggttcaacacggtc	9	13	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:81194452C>A	uc002fgh.1	-	22	3536	c.3536G>T	c.(3535-3537)AGT>ATT	p.S1179I	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1179	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGCTTCAGGACTGGTCAGGTT	0.552													1	0	4.68919e-08	0.069234	4.84313e-08	9	32										A	81194452	C	A	81194452	3	1	41	1	0	0	0	0	1	0	0	0	11965	565	20	4	3930	4	PKD1L2	16	81194452	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	8270677	81194452	9160301	248	10666										
KIAA0182	23199	broad.mit.edu	37	chr16	85701811	85701811	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cgtccgtccactacaacattCctgagctgcagtcctccagc	7	17	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:85701811C>G	uc002fix.2	+	14	3270	c.3196C>G	c.(3196-3198)CCT>GCT	p.P1066A	KIAA0182_uc002fiw.2_Missense_Mutation_p.P962A|KIAA0182_uc002fiy.2_Missense_Mutation_p.P993A|KIAA0182_uc002fiz.2_Missense_Mutation_p.P208A|KIAA0182_uc010cho.2_Missense_Mutation_p.P246A	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	1066							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CTACAACATTCCTGAGCTGCA	0.637													0	0	0	0.039052	0	43	109										G	85701811	C	G	85701811	3	3	41	1	0	0	0	0	1	0	0	0	8159	855	30	1	3250	1	KIAA0182	16	85701811	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	4507359	85701811	4652942	249	10667										
FANCA	2175	broad.mit.edu	37	chr16	89805349	89805349	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tattaactgcagcagaaaaaGacgagcttttgttatcagtt	8	6	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr16:89805349G>C	uc002fou.1	-	42	4243	c.4201C>G	c.(4201-4203)CTT>GTT	p.L1401V	ZNF276_uc010ciq.2_3'UTR|ZNF276_uc002foq.3_3'UTR|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_3'UTR|ZNF276_uc010cis.2_3'UTR|ZNF276_uc002fos.3_3'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_3'UTR|FANCA_uc010vpn.1_Missense_Mutation_p.S1402C	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1401					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		AGCAGAAAAAGACGAGCTTTT	0.512			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.048971	0	70	63										C	89805349	G	C	89805349	3	2	41	1	0	0	0	0	1	0	0	0	5662	942	33	1	174	1	FANCA	16	89805349	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4103538	89805349	549404	250	10668										
C17orf85	55421	broad.mit.edu	37	chr17	3721711	3721711	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggatcgtctagacgcgctccGctcccggggctgcttgagag	15	13	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:3721711G>A	uc010ckl.1	-	10	1179	c.1156C>T	c.(1156-1158)CGG>TGG	p.R386W	C17orf85_uc002fwr.2_Missense_Mutation_p.R96W|C17orf85_uc002fwq.2_Missense_Mutation_p.R106W	NM_001114118	NP_001107590	Q53F19	CQ085_HUMAN	ELG protein isoform a	386							nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		GACGCGCTCCGCTCCCGGGGC	0.473													0	0	0	0.069456	0	33	93										A	3721711	G	A	3721711	3	1	41	1	0	0	0	0	1	0	0	0	1888	1086	38	2	722	2	C17orf85	17	3721711	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		3721711	77473499	251	10669										
ZNF594	84622	broad.mit.edu	37	chr17	5085754	5085754	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	attgaaagttttcccacattCtttgcattcatatggtttct	5	8	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:5085754C>G	uc010cla.1	-	2	1954	c.1798G>C	c.(1798-1800)GAA>CAA	p.E600Q		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	600	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTCCCACATTCTTTGCATTCA	0.408													0	0	0	0.048971	0	175	136										G	5085754	C	G	5085754	3	3	41	1	0	0	0	0	1	0	0	0	18021	922	32	1	629	1	ZNF594	17	5085754	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1364043	5085754	76109456	252	10670										
TP53	7157	broad.mit.edu	37	chr17	7578449	7578449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgtgactgcttgtagatggCcatggcgcggacgcgggtgc	17	10	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:7578449C>T	uc002gim.2	-	5	675	c.481G>A	c.(481-483)GCC>ACC	p.A161T	TP53_uc002gig.1_Missense_Mutation_p.A161T|TP53_uc002gih.2_Missense_Mutation_p.A161T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A29T|TP53_uc010cng.1_Missense_Mutation_p.A29T|TP53_uc002gii.1_Missense_Mutation_p.A29T|TP53_uc010cnh.1_Missense_Mutation_p.A161T|TP53_uc010cni.1_Missense_Mutation_p.A161T|TP53_uc002gij.2_Missense_Mutation_p.A161T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A68T|TP53_uc002gio.2_Missense_Mutation_p.A29T|TP53_uc010vug.1_Missense_Mutation_p.A122T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	161	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		MA -> IP (in a sporadic cancer; somatic mutation).|MA -> IS (in sporadic cancers; somatic mutation).|MA -> IT (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|A -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A161T(44)|p.A161D(8)|p.0?(7)|p.A161V(7)|p.A161A(5)|p.A161fs*9(3)|p.R156_I162delRVRAMAI(2)|p.M160fs*10(2)|p.V157_C176del20(1)|p.A161fs*19(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.A161fs*10(1)|p.R156_A161del(1)|p.V157fs*9(1)|p.A161fs*20(1)|p.M160_A161>IS(1)|p.A161fs*8(1)|p.A161G(1)|p.S149fs*72(1)|p.A161fs*7(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.A161S(1)|p.A161P(1)|p.V157_I162delVRAMAI(1)|p.A161F(1)|p.A159_Q167delAMAIYKQSQ(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGTAGATGGCCATGGCGCGG	0.632		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.09836	0	40	39										T	7578449	C	T	7578449	3	4	41	1	0	0	0	0	1	0	0	0	16378	739	26	2	817	2	TP53	17	7578449	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2492695	7578449	73616761	253	10671										
CCDC144A	9720	broad.mit.edu	37	chr17	16623915	16623915	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagaggattgtgaattgtctCactctgtttatgagaatttt	9	5	2	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:16623915C>T	uc002gqk.1	+	8	1910	c.1834C>T	c.(1834-1836)CAC>TAC	p.H612Y	CCDC144A_uc002gql.1_Missense_Mutation_p.H82Y|LOC162632_uc010cpj.1_RNA	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	612											0						TGAATTGTCTCACTCTGTTTA	0.373													0	0	0	0.02938	0	5	40										T	16623915	C	T	16623915	3	4	41	1	0	0	0	0	1	0	0	0	2777	826	29	1	1864	1	CCDC144A	17	16623915	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9045466	16623915	64571295	254	10672										
DRG2	1819	broad.mit.edu	37	chr17	18004839	18004839	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cagaagtgcttttccgagaaGactgctccccggacgagttc	11	12	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:18004839G>C	uc002gsh.1	+	8	719	c.664G>C	c.(664-666)GAC>CAC	p.D222H	DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.D222H	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	222					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)					TTTCCGAGAAGACTGCTCCCC	0.607													0	0	0	0.054565	0	31	45										C	18004839	G	C	18004839	3	2	41	1	0	0	0	0	1	0	0	0	4762	942	33	1	694	1	DRG2	17	18004839	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1380924	18004839	63190371	255	10673										
DRG2	1819	broad.mit.edu	37	chr17	18005268	18005268	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcgaccagatctccatggaaGaggtggaccgcctggcccga	13	13	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:18005268G>A	uc002gsh.1	+	9	818	c.763G>A	c.(763-765)GAG>AAG	p.E255K	DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.E255K	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	255					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)					CTCCATGGAAGAGGTGGACCG	0.567													0	0	0	0.038395	0	16	8										A	18005268	G	A	18005268	3	1	41	1	0	0	0	0	1	0	0	0	4762	943	33	1	797	1	DRG2	17	18005268	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	429	18005268	63189942	256	10674										
CCDC144B	284047	broad.mit.edu	37	chr17	18498091	18498091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aaaattctcataaacagagtGagacaattcacaatcctctg	5	9	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:18498091G>A	uc002gub.1	-	8	1919	c.1834C>T	c.(1834-1836)CAC>TAC	p.H612Y	CCDC144B_uc002gua.3_RNA|CCDC144B_uc010vyc.1_RNA	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2						TAAACAGAGTGAGACAATTCA	0.373													0	0	0	0.038147	0	6	50										A	18498091	G	A	18498091	3	1	41	1	0	0	0	0	1	0	0	0	2778	1290	45	1	354	1	CCDC144B	17	18498091	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	492823	18498091	62697119	257	10675										
SSH2	85464	broad.mit.edu	37	chr17	27975200	27975200	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgatactcttccagttgtctCatgaagcttgggttgggctt	11	8	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:27975200C>G	uc002heo.1	-	13	1308	c.1308G>C	c.(1306-1308)ATG>ATC	p.M436I	SSH2_uc010wbh.1_Missense_Mutation_p.M463I|SSH2_uc002hep.1_Missense_Mutation_p.M436I	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	436	Tyrosine-protein phosphatase.				actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CCAGTTGTCTCATGAAGCTTG	0.458													0	0	0	0.048971	0	70	151										G	27975200	C	G	27975200	3	3	41	1	0	0	0	0	1	0	0	0	15184	826	29	1	2975	1	SSH2	17	27975200	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9477109	27975200	53220010	258	10676										
ERBB2	2064	broad.mit.edu	37	chr17	37868216	37868216	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cggacgtgggatcctgcaccCtcgtctgccccctgcacaac	10	18	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:37868216C>G	uc002hso.2	+	8	1175	c.937C>G	c.(937-939)CTC>GTC	p.L313V	ERBB2_uc002hsm.2_Missense_Mutation_p.L283V|ERBB2_uc010cwa.2_Missense_Mutation_p.L298V|ERBB2_uc002hsp.2_Missense_Mutation_p.L116V|ERBB2_uc010cwb.2_Missense_Mutation_p.L313V|ERBB2_uc010wek.1_Missense_Mutation_p.L37V|ERBB2_uc002hsl.2_Missense_Mutation_p.L283V|ERBB2_uc002hsn.1_Missense_Mutation_p.L313V	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	313	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCCTGCACCCTCGTCTGCCC	0.572		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.048971	0	837	31										G	37868216	C	G	37868216	3	3	41	1	0	0	0	0	1	0	0	0	5206	681	24	4	967	4	ERBB2	17	37868216	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9893016	37868216	43326994	259	10677										
ANKRD40	91369	broad.mit.edu	37	chr17	48776867	48776867	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gagacattggtggcttggacGggacagaagaaaacagggag	17	5	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:48776867G>C	uc002iso.2	-	3	926	c.671C>G	c.(670-672)CCG>CGG	p.P224R		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	224	Pro-rich.										0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			TGGCTTGGACGGGACAGAAGA	0.527													0	0	0	0.054565	0	27	94										C	48776867	G	C	48776867	3	2	41	1	0	0	0	0	1	0	0	0	669	1116	39	4	447	4	ANKRD40	17	48776867	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	10908651	48776867	32418343	260	10678										
TEX14	56155	broad.mit.edu	37	chr17	56671019	56671019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccagggtcacaaagagtcgGcagcttaaaaagcaataaac	9	9	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:56671019G>A	uc010dcz.1	-	15	2609	c.2491C>T	c.(2491-2493)CCG>TCG	p.P831S	TEX14_uc002iwr.1_Missense_Mutation_p.P825S|TEX14_uc002iws.1_Missense_Mutation_p.P825S|TEX14_uc010dda.1_Missense_Mutation_p.P605S	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	831						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAAAGAGTCGGCAGCTTAAAA	0.408													0	0	0	0.009096	0	4	81										A	56671019	G	A	56671019	3	1	41	1	0	0	0	0	1	0	0	0	15775	1203	42	2	2078	2	TEX14	17	56671019	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	7894152	56671019	24524191	261	10679										
KCNH6	81033	broad.mit.edu	37	chr17	61611504	61611504	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctcatcgtggacatcatgttCgtcgtggacatcgtcatcaa	9	11	4	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:61611504C>T	uc002jay.2	+	5	1013	c.933C>T	c.(931-933)TTC>TTT	p.F311F	KCNH6_uc002jax.1_Silent_p.F311F|KCNH6_uc010wpl.1_Silent_p.F188F|KCNH6_uc010wpm.1_Silent_p.F311F|KCNH6_uc002jaz.1_Silent_p.F311F	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	311	Helical; Name=Segment S2; (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	ACATCATGTTCGTCGTGGACA	0.587													0	0	0	0.099896	0	24	353										T	61611504	C	T	61611504	2	4	41	1	0	0	0	0	0	0	0	1	8036	883	31	1		1	KCNH6	17	61611504	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	4940485	61611504	19583706	262	10680										
ABCA10	10349	broad.mit.edu	37	chr17	67178946	67178946	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcacgaggtcttcaatatttGatcctaacatagtggaagga	10	7	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:67178946G>C	uc010dfa.1	-	22	3380	c.2501C>G	c.(2500-2502)TCA>TGA	p.S834*	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Nonsense_Mutation_p.S435*	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	834					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTCAATATTTGATCCTAACAT	0.333													0	0	0	0.038147	0	8	47										C	67178946	G	C	67178946	4	2	41	1	0	0	0	0	0	1	0	0	29	1294	45	1	2206	1	ABCA10	17	67178946	Nonsense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	5567442	67178946	14016264	263	10681										
DNAI2	64446	broad.mit.edu	37	chr17	72297252	72297252	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gatcttggacatcaccaagaAggaacagttggaaaatgcct	10	8	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:72297252A>G	uc002jkf.2	+	8	1031	c.932A>G	c.(931-933)AAG>AGG	p.K311R	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	311					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						ATCACCAAGAAGGAACAGTTG	0.547									Kartagener_syndrome				0	0	0	0.048971	0	103	172										G	72297252	A	G	72297252	3	3	41	1	0	0	0	0	1	0	0	0	4610	72	3	5	958	5	DNAI2	17	72297252	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	5118306	72297252	8897958	264	10682										
EIF4A3	9775	broad.mit.edu	37	chr17	78118038	78118038	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctggattgctgatggtttttCaaaacctgcaaataaaaaca	7	7	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:78118038C>G	uc010wuc.1	-	3	248	c.175G>C	c.(175-177)GAA>CAA	p.E59Q	EIF4A3_uc002jxs.2_Missense_Mutation_p.E59Q	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	59	Q motif.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			GATGGTTTTTCAAAACCTGCA	0.378													0	0	0	0.02938	0	7	70										G	78118038	C	G	78118038	3	3	41	1	0	0	0	0	1	0	0	0	5026	835	29	1	1104	1	EIF4A3	17	78118038	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	5820786	78118038	3077172	265	10683										
AZI1	22994	broad.mit.edu	37	chr17	79164797	79164797	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcctccccaagctggcccttCagctccgagcaccgctcctg	9	20	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:79164797C>G	uc002jzp.1	-	23	3062	c.2862G>C	c.(2860-2862)CTG>CTC	p.L954L	AZI1_uc002jzm.1_Silent_p.L386L|AZI1_uc002jzn.1_Silent_p.L951L|AZI1_uc002jzo.1_Silent_p.L915L|AZI1_uc010wum.1_Silent_p.L918L|AZI1_uc002jzq.2_Silent_p.L102L	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	954					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCTGGCCCTTCAGCTCCGAGC	0.677													0	0	0	0.020292	0	13	55										G	79164797	C	G	79164797	2	3	41	1	0	0	0	0	0	0	0	1	1240	813	29	1		1	AZI1	17	79164797	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1046759	79164797	2030413	266	10684			2	44		4	4	325	C		6.304711e-09
AZI1	22994	broad.mit.edu	37	chr17	79164838	79164838	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aagcttccgctccgactgctCcagctcggagagctcggcct	11	16	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:79164838C>G	uc002jzp.1	-	23	3021	c.2821G>C	c.(2821-2823)GAG>CAG	p.E941Q	AZI1_uc002jzm.1_Missense_Mutation_p.E373Q|AZI1_uc002jzn.1_Missense_Mutation_p.E938Q|AZI1_uc002jzo.1_Missense_Mutation_p.E902Q|AZI1_uc010wum.1_Missense_Mutation_p.E905Q|AZI1_uc002jzq.2_Missense_Mutation_p.E89Q	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	941					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TCCGACTGCTCCAGCTCGGAG	0.662													0	0	0	0.049695	0	20	76										G	79164838	C	G	79164838	3	3	41	1	0	0	0	0	1	0	0	0	1240	864	30	1	446	1	AZI1	17	79164838	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	41	79164838	2030372	267	10685			2	44		4	4	325	C		6.304711e-09
AZI1	22994	broad.mit.edu	37	chr17	79165108	79165108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccggatttcttccctcagctCctgttcccggttcagcagcc	8	17	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:79165108C>T	uc002jzp.1	-	22	2859	c.2659G>A	c.(2659-2661)GAG>AAG	p.E887K	AZI1_uc002jzm.1_Missense_Mutation_p.E319K|AZI1_uc002jzn.1_Missense_Mutation_p.E884K|AZI1_uc002jzo.1_Missense_Mutation_p.E848K|AZI1_uc010wum.1_Missense_Mutation_p.E851K|AZI1_uc002jzq.2_Missense_Mutation_p.E35K	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	887					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TCCCTCAGCTCCTGTTCCCGG	0.677													0	0	0	0.050027	0	33	94										T	79165108	C	T	79165108	3	4	41	1	0	0	0	0	1	0	0	0	1240	864	30	1	612	1	AZI1	17	79165108	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	270	79165108	2030102	268	10686			2	44		4	4	325	C		6.304711e-09
AZI1	22994	broad.mit.edu	37	chr17	79165121	79165121	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctcagctcctgttcccggttCagcagccacgcctcctgggg	11	17	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:79165121C>T	uc002jzp.1	-	22	2846	c.2646G>A	c.(2644-2646)CTG>CTA	p.L882L	AZI1_uc002jzm.1_Silent_p.L314L|AZI1_uc002jzn.1_Silent_p.L879L|AZI1_uc002jzo.1_Silent_p.L843L|AZI1_uc010wum.1_Silent_p.L846L|AZI1_uc002jzq.2_Silent_p.L30L	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	882					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GTTCCCGGTTCAGCAGCCACG	0.701													0	0	0	0.083992	0	23	77										T	79165121	C	T	79165121	2	4	41	1	0	0	0	0	0	0	0	1	1240	813	29	1		1	AZI1	17	79165121	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	13	79165121	2030089	269	10687			2	44		4	4	325	C		6.304711e-09
FASN	2194	broad.mit.edu	37	chr17	80053331	80053331	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttcagcttgccggaccgccGgggcaggccgtagagccctg	15	15	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr17:80053331G>A	uc002kdu.2	-	3	262	c.145C>T	c.(145-147)CGG>TGG	p.R49W		NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	49	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CCGGACCGCCGGGGCAGGCCG	0.652													0	0	0	0.074837	0	32	29										A	80053331	G	A	80053331	3	1	41	1	0	0	0	0	1	0	0	0	5683	1115	39	2	7554	2	FASN	17	80053331	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	888210	80053331	1141879	270	10688										
ZNF519	162655	broad.mit.edu	37	chr18	14105771	14105771	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttttctccagtgttaattatCttatgtccctttagatgtga	6	7	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr18:14105771C>G	uc002kst.1	-	3	921	c.768G>C	c.(766-768)AAG>AAC	p.K256N	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTTAATTATCTTATGTCCCT	0.328													0	0	0	0.020292	0	15	10										G	14105771	C	G	14105771	3	3	41	1	0	0	0	0	1	0	0	0	17961	912	32	1	858	1	ZNF519	18	14105771	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		14105771	63971477	271	10689										
ELP2	55250	broad.mit.edu	37	chr18	33722264	33722264	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tttcagaaagtgctttctctCtgtggacatgaggattggat	11	6	3	2	rs142567516		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr18:33722264C>G	uc002kzk.1	+	7	619	c.609C>G	c.(607-609)CTC>CTG	p.L203L	ELP2_uc010xcg.1_Silent_p.L268L|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Silent_p.L177L|ELP2_uc010xch.1_Silent_p.L242L|ELP2_uc002kzn.1_Silent_p.L177L|ELP2_uc002kzo.1_Intron	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	203					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TGCTTTCTCTCTGTGGACATG	0.373													0	0	0	0.0333	0	16	85										G	33722264	C	G	33722264	2	3	41	1	0	0	0	0	0	0	0	1	5080	900	32	1		1	ELP2	18	33722264	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	19616493	33722264	44354984	272	10690										
KIAA1632	57724	broad.mit.edu	37	chr18	43450556	43450556	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aagaaggcctccatgagcatCtggtcagggtgcaggtcctt	13	10	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr18:43450556C>G	uc002lbm.2	-	36	6301	c.6201G>C	c.(6199-6201)CAG>CAC	p.Q2067H	KIAA1632_uc010xcq.1_Missense_Mutation_p.Q621H|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_Intron|KIAA1632_uc002lbn.2_Missense_Mutation_p.Q942H	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2067					autophagy						0						CCATGAGCATCTGGTCAGGGT	0.517													0	0	0	0.058154	0	9	30										G	43450556	C	G	43450556	3	3	41	1	0	0	0	0	1	0	0	0	8249	912	32	1	1574	1	KIAA1632	18	43450556	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9728292	43450556	34626692	273	10691										
TXNL1	9352	broad.mit.edu	37	chr18	54291545	54291545	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttttggaatatctgtgtcctCattgcttccagggtcatttt	8	8	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr18:54291545C>G	uc002lgg.2	-	3	592	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	TXNL1_uc010xdz.1_RNA|TXNL1_uc002lgh.2_RNA|TXNL1_uc002lgi.2_Missense_Mutation_p.E115Q|TXNL1_uc002lgj.1_Missense_Mutation_p.E115Q	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1	115	PITH.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)		TCTGTGTCCTCATTGCTTCCA	0.333													0	0	0	0.054565	0	34	143										G	54291545	C	G	54291545	3	3	41	1	0	0	0	0	1	0	0	0	16801	835	29	1	550	1	TXNL1	18	54291545	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	10840989	54291545	23785703	274	10692										
ZNF555	148254	broad.mit.edu	37	chr19	2853300	2853300	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtcacccctcctcctttcgaGgacacatgagggtgcacact	9	15	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:2853300G>A	uc002lwo.2	+	4	1326	c.1237G>A	c.(1237-1239)GGA>AGA	p.G413R	ZNF555_uc002lwn.3_Missense_Mutation_p.G412R	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	413	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCTTTCGAGGACACATGAG	0.473													0	0	0	0.009096	0	4	62										A	2853300	G	A	2853300	3	1	41	1	0	0	0	0	1	0	0	0	17983	1001	35	2	1251	2	ZNF555	19	2853300	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		2853300	56275683	275	10693										
MUC16	94025	broad.mit.edu	37	chr19	9067796	9067796	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccagcatatctgtggtcttCactaggccagaggtggggag	15	9	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:9067796C>T	uc002mkp.2	-	3	19854	c.19650G>A	c.(19648-19650)GTG>GTA	p.V6550V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6552	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGGTCTTCACTAGGCCAG	0.483													0	0	0	0.049695	0	20	15										T	9067796	C	T	9067796	2	4	41	1	0	0	0	0	0	0	0	1	9973	813	29	1		1	MUC16	19	9067796	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6214496	9067796	50061187	276	10694										
ICAM1	3383	broad.mit.edu	37	chr19	10394842	10394842	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cacctggcactgggggaccaGaggttgaaccccacagtcac	12	14	1	2	rs139628843		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:10394842G>C	uc002mnq.2	+	4	1090	c.771G>C	c.(769-771)CAG>CAC	p.Q257H	ICAM1_uc010xle.1_Missense_Mutation_p.Q35H|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	257	Ig-like C2-type 3.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	TGGGGGACCAGAGGTTGAACC	0.657													0	0	0	0.02938	0	6	75										C	10394842	G	C	10394842	3	2	41	1	0	0	0	0	1	0	0	0	7479	933	33	1	785	1	ICAM1	19	10394842	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1327046	10394842	48734141	277	10695										
SMARCA4	6597	broad.mit.edu	37	chr19	11123726	11123726	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	accatccagaccatcgcgctCatcacgtacctcatggagca	7	16	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:11123726C>T	uc002mqf.3	+	16	2660	c.2376C>T	c.(2374-2376)CTC>CTT	p.L792L	SMARCA4_uc010dxp.2_Silent_p.L792L|SMARCA4_uc010dxo.2_Silent_p.L792L|SMARCA4_uc002mqg.1_Silent_p.L792L|SMARCA4_uc010dxq.2_Silent_p.L792L|SMARCA4_uc010dxr.2_Silent_p.L792L|SMARCA4_uc002mqj.3_Silent_p.L792L|SMARCA4_uc010dxs.2_Silent_p.L792L|SMARCA4_uc010dxt.1_Silent_p.L12L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	792	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCATCGCGCTCATCACGTACC	0.582			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.045705	0	31	31										T	11123726	C	T	11123726	2	4	41	1	0	0	0	0	0	0	0	1	14770	813	29	1		1	SMARCA4	19	11123726	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	728884	11123726	48005257	278	10696										
CYP4F12	66002	broad.mit.edu	37	chr19	15794481	15794481	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgtcatccgggagcggcgtCgcaccctccccactcagggt	12	17	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:15794481C>T	uc002nbl.2	+	7	887	c.826C>T	c.(826-828)CGC>TGC	p.R276C		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GGAGCGGCGTCGCACCCTCCC	0.532													0	0	0	0.048971	0	54	118										T	15794481	C	T	15794481	3	4	41	1	0	0	0	0	1	0	0	0	4187	884	31	1	848	1	CYP4F12	19	15794481	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	4670755	15794481	43334502	279	10697										
CYP4F2	8529	broad.mit.edu	37	chr19	16001184	16001184	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgtccaaggtcatgaggctGatgtgctcaaacatatccaa	9	10	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:16001184G>A	uc002nbs.1	-	6	635	c.585C>T	c.(583-585)ATC>ATT	p.I195I	CYP4F2_uc010xot.1_Silent_p.I46I|CYP4F2_uc010xou.1_Silent_p.I46I	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	195					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						TCATGAGGCTGATGTGCTCAA	0.542													0	0	0	0.048971	0	68	69										A	16001184	G	A	16001184	2	1	41	1	0	0	0	0	0	0	0	1	4188	1280	45	1		1	CYP4F2	19	16001184	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	206703	16001184	43127799	280	10698										
GMIP	51291	broad.mit.edu	37	chr19	19741332	19741332	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acgtcctctctctggtcactCtgtggagttggaatctgcag	11	11	5	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:19741332C>G	uc002nnd.2	-	20	2604	c.2487G>C	c.(2485-2487)CAG>CAC	p.Q829H	LPAR2_uc002nnb.3_5'Flank|LPAR2_uc002nna.3_5'Flank|LPAR2_uc002nnc.3_5'Flank|GMIP_uc010xrb.1_Missense_Mutation_p.Q803H|GMIP_uc010xrc.1_Missense_Mutation_p.Q800H	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	829					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						TCTGGTCACTCTGTGGAGTTG	0.542													0	0	0	0.048971	0	71	46										G	19741332	C	G	19741332	3	3	41	1	0	0	0	0	1	0	0	0	6491	912	32	1	433	1	GMIP	19	19741332	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3740148	19741332	39387651	281	10699										
WDR62	284403	broad.mit.edu	37	chr19	36562497	36562497	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tctgtgtcagccaggagctcAtcttctgtggctgcacagat	11	11	5	1	rs146229976	byFrequency	TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:36562497A>G	uc002odc.2	+	8	1013	c.922A>G	c.(922-924)ATC>GTC	p.I308V	WDR62_uc002odd.2_Missense_Mutation_p.I308V|WDR62_uc002odb.2_Missense_Mutation_p.I308V	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	308	WD 4.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCAGGAGCTCATCTTCTGTGG	0.592													0	0	0	0.02938	0	7	168										G	36562497	A	G	36562497	3	3	41	1	0	0	0	0	1	0	0	0	17310	217	8	5	952	5	WDR62	19	36562497	Missense_Mutation	SNP	A	TCGA-DK-A1A5-01A-11D-A13W-08	16821165	36562497	22566486	282	10700										
WDR62	284403	broad.mit.edu	37	chr19	36574043	36574043	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acttcccagaccgggggagcGagaatgggacacccatggac	14	12	0	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:36574043G>A	uc002odc.2	+	11	1541	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	WDR62_uc002odd.2_Missense_Mutation_p.E484K	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	484					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCGGGGGAGCGAGAATGGGAC	0.597													0	0	0	0.004672	0	3	36										A	36574043	G	A	36574043	3	1	41	1	0	0	0	0	1	0	0	0	17310	1059	37	1	1492	1	WDR62	19	36574043	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	11546	36574043	22554940	283	10701										
ACTN4	81	broad.mit.edu	37	chr19	39220017	39220017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gggccctgacgccgtgcccgGtgccctcgactacaagtcct	12	17	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:39220017G>A	uc002oja.1	+	21	2740	c.2681G>A	c.(2680-2682)GGT>GAT	p.G894D	ACTN4_uc002ojb.1_Missense_Mutation_p.G216D	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	894					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCCGTGCCCGGTGCCCTCGAC	0.672													0	0	0	0.069234	0	10	39										A	39220017	G	A	39220017	3	1	41	1	0	0	0	0	1	0	0	0	207	1261	44	2	2763	2	ACTN4	19	39220017	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	2645974	39220017	19908966	284	10702										
SARS2	54938	broad.mit.edu	37	chr19	39421110	39421110	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccggcgcaggcgcactcacGatcgcgggcaggtccgccga	16	16	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:39421110G>A	uc002oka.2	-	1	427	c.267C>T	c.(265-267)ATC>ATT	p.I89I	SARS2_uc002ojz.2_5'Flank|SARS2_uc010xup.1_Silent_p.I89I|SARS2_uc002okb.2_Silent_p.I89I|SARS2_uc010xuq.1_Intron|SARS2_uc010xur.1_RNA|SARS2_uc010xus.1_Silent_p.I89I|MRPS12_uc002okc.2_5'Flank|MRPS12_uc002okd.2_5'Flank|MRPS12_uc002oke.2_5'Flank	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	89					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GCGCACTCACGATCGCGGGCA	0.662											OREG0032101|OREG0025455	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)|type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.039052	0	39	175										A	39421110	G	A	39421110	2	1	41	1	0	0	0	0	0	0	0	1	13845	1072	37	1		1	SARS2	19	39421110	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	201093	39421110	19707873	285	10703										
RTN2	6253	broad.mit.edu	37	chr19	45997499	45997499	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccccttactggctctcgctCcagtggcccccactgctttt	7	18	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:45997499C>G	uc002pcb.2	-	4	967	c.739G>C	c.(739-741)GAG>CAG	p.E247Q	RTN2_uc002pcc.2_Missense_Mutation_p.E247Q|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	247						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		GGCTCTCGCTCCAGTGGCCCC	0.577													0	0	0	0.048971	0	154	78										G	45997499	C	G	45997499	3	3	41	1	0	0	0	0	1	0	0	0	13726	864	30	1	930	1	RTN2	19	45997499	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6576389	45997499	13131484	286	10704										
CGB7	94027	broad.mit.edu	37	chr19	49558233	49558233	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tccctggatgcccatgtcccGcccatgctcagcagcagcaa	9	17	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:49558233G>A	uc002pmd.2	-	2	413	c.48C>T	c.(46-48)GGC>GGT	p.G16G	CGB_uc010yad.1_Intron|CGB8_uc002pmc.2_Intron|CGB7_uc002pme.2_Silent_p.G16G	NM_033142	NP_149133	P01233	CGHB_HUMAN	chorionic gonadotropin, beta polypeptide 7	16					apoptosis|cell-cell signaling|cellular nitrogen compound metabolic process|female gamete generation|hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Choriogonadotropin alfa(DB00097)	CCCATGTCCCGCCCATGCTCA	0.667													0	0	0	0.048971	0	61	25										A	49558233	G	A	49558233	2	1	41	1	0	0	0	0	0	0	0	1	3300	1074	38	2		2	CGB7	19	49558233	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	3560734	49558233	9570750	287	10705										
POLD1	5424	broad.mit.edu	37	chr19	50921177	50921177	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gagcagctcctgcggcgcttCggaccccctggacctgaggc	14	16	0	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:50921177C>G	uc002psb.3	+	27	3353	c.3297C>G	c.(3295-3297)TTC>TTG	p.F1099L	POLD1_uc002psc.3_Missense_Mutation_p.F1099L|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.F1125L|SPIB_uc002psd.2_5'Flank|SPIB_uc002pse.2_5'Flank|SPIB_uc010ycc.1_5'Flank	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	1099					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TGCGGCGCTTCGGACCCCCTG	0.622								DNA_polymerases_(catalytic_subunits)					0	0	0	0.058154	0	8	11										G	50921177	C	G	50921177	3	3	41	1	0	0	0	0	1	0	0	0	12190	883	31	1	3399	1	POLD1	19	50921177	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1362944	50921177	8207806	288	10706										
SIGLEC8	27181	broad.mit.edu	37	chr19	51957508	51957508	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cctgatggcctttgcatcttCcatgcctgtatcccccacgc	7	17	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:51957508C>G	uc002pwt.2	-	6	1277	c.1210G>C	c.(1210-1212)GAA>CAA	p.E404Q	SIGLEC8_uc010yda.1_Missense_Mutation_p.E295Q|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.E311Q	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	404	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TTTGCATCTTCCATGCCTGTA	0.597													0	0	0	0.076483	0	21	143										G	51957508	C	G	51957508	3	3	41	1	0	0	0	0	1	0	0	0	14314	864	30	1	297	1	SIGLEC8	19	51957508	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1036331	51957508	7171475	289	10707										
ZNF28	7576	broad.mit.edu	37	chr19	53303274	53303274	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtcttgccacactcattacaCttgtaaggtttctctccagt	6	12	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr19:53303274C>T	uc002qad.2	-	4	1944	c.1824G>A	c.(1822-1824)AAG>AAA	p.K608K	ZNF28_uc002qac.2_Silent_p.K555K|ZNF28_uc010eqe.2_Silent_p.K554K	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	608	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		ACTCATTACACTTGTAAGGTT	0.448													0	0	0	0.048971	0	196	98										T	53303274	C	T	53303274	2	4	41	1	0	0	0	0	0	0	0	1	17810	564	20	2		2	ZNF28	19	53303274	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1345766	53303274	5825709	290	10708										
C20orf71	128861	broad.mit.edu	37	chr20	31805357	31805357	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaccctatgatgtgtccactCtggaggctcctcatcttcct	8	14	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:31805357C>T	uc002wyr.2	+	1	223	c.15C>T	c.(13-15)CTC>CTT	p.L5L	C20orf71_uc002wys.2_Silent_p.L5L	NM_178466	NP_848561	Q9BQP9	SPLC3_HUMAN	short long palate, lung and nasal epithelium	5						extracellular region	lipid binding			ovary(1)|skin(1)	2						TGTGTCCACTCTGGAGGCTCC	0.592													0	0	0	0.076483	0	25	86										T	31805357	C	T	31805357	2	4	41	1	0	0	0	0	0	0	0	1	2117	900	32	1		1	C20orf71	20	31805357	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08		31805357	31220163	291	10709										
MMP24	10893	broad.mit.edu	37	chr20	33862215	33862216	+	Frame_Shift_Ins	INS	-	-	G													0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggagcggcggaaggagcggcINSggctgccccaggacgacgtg							TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:33862215_33862216insG	uc002xbu.2	+	9	1744_1745	c.1741_1742insG	c.(1741-1743)CGGfs	p.R581fs	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	581	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GAAGGAGCGGCGGCTGCCCCAG	0.644																		7	221	---	---								G	33862216	-	G	33862215	7	5	41	1	0	1	1	0	0	0	0	0	9661	759	27	0	1525	0	MMP24	20	33862215	Frame_Shift_Ins	INS	-	TCGA-DK-A1A5-01A-11D-A13W-08	2056858	33862215	29163305	292	10710										
EPB41L1	2036	broad.mit.edu	37	chr20	34797659	34797659	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tcgaagacttctcccgcagcCtgcctgagctcgaccgggac	11	16	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:34797659C>G	uc002xfb.2	+	15	2089	c.1918C>G	c.(1918-1920)CTG>GTG	p.L640V	EPB41L1_uc002xeu.2_Missense_Mutation_p.L566V|EPB41L1_uc010zvo.1_Missense_Mutation_p.L640V|EPB41L1_uc002xev.2_Missense_Mutation_p.L640V|EPB41L1_uc002xew.2_Missense_Mutation_p.L531V|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Missense_Mutation_p.L566V|EPB41L1_uc010gfq.2_Missense_Mutation_p.L739V	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	640					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CTCCCGCAGCCTGCCTGAGCT	0.612													0	0	0	0.045705	0	31	64										G	34797659	C	G	34797659	3	3	41	1	0	0	0	0	1	0	0	0	5152	680	24	4	1972	4	EPB41L1	20	34797659	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	935444	34797659	28227861	293	10711										
SAMHD1	25939	broad.mit.edu	37	chr20	35521386	35521386	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctgcttttggatgcttctcgGaggcgagttggattttggac	14	7	1	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:35521386G>A	uc002xgh.1	-	16	1960	c.1830C>T	c.(1828-1830)CTC>CTT	p.L610L	C20orf118_uc002xgg.1_3'UTR|SAMHD1_uc010gft.1_RNA	NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	610					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				ATGCTTCTCGGAGGCGAGTTG	0.428													0	0	0	0.048971	0	93	163										A	35521386	G	A	35521386	2	1	41	1	0	0	0	0	0	0	0	1	13828	1161	41	1		1	SAMHD1	20	35521386	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	723727	35521386	27504134	294	10712										
YWHAB	7529	broad.mit.edu	37	chr20	43535062	43535062	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agggagacgaaggagacgctGgggagggagagaactaatgt	19	4	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:43535062G>A	uc002xmt.2	+	7	1006	c.724G>A	c.(724-726)GGG>AGG	p.G242R	YWHAB_uc002xmu.2_Missense_Mutation_p.G242R	NM_003404	NP_003395	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan	242					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			kidney(2)|ovary(1)|breast(1)	4		Myeloproliferative disorder(115;0.0122)				AGGAGACGCTGGGGAGGGAGA	0.438													0	0	0	0.080422	0	34	82										A	43535062	G	A	43535062	3	1	41	1	0	0	0	0	1	0	0	0	17498	1348	47	2	742	2	YWHAB	20	43535062	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	8013676	43535062	19490458	295	10713										
STAU1	6780	broad.mit.edu	37	chr20	47734529	47734529	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atctttggtgtgatgtccttGactaactcctacagcctggg	10	10	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:47734529G>C	uc002xud.2	-	11	1705	c.1294C>G	c.(1294-1296)CAA>GAA	p.Q432E	STAU1_uc002xua.2_Missense_Mutation_p.Q351E|STAU1_uc002xub.2_Missense_Mutation_p.Q357E|STAU1_uc002xuc.2_Missense_Mutation_p.Q351E|STAU1_uc002xue.2_Missense_Mutation_p.Q351E|STAU1_uc002xuf.2_Missense_Mutation_p.Q357E|STAU1_uc002xug.2_Missense_Mutation_p.Q432E	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	432						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TGATGTCCTTGACTAACTCCT	0.532													0	0	0	0.048971	0	55	142										C	47734529	G	C	47734529	3	2	41	1	0	0	0	0	1	0	0	0	15271	1299	45	1	455	1	STAU1	20	47734529	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4199467	47734529	15290991	296	10714										
NFATC2	4773	broad.mit.edu	37	chr20	50049280	50049280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tattcatccgtgggctccgtCttgatggctgggactgggag	15	9	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:50049280C>T	uc002xwd.2	-	9	2266	c.2046G>A	c.(2044-2046)AAG>AAA	p.K682K	NFATC2_uc002xwc.2_Silent_p.K682K|NFATC2_uc010zyv.1_Silent_p.K463K|NFATC2_uc010zyw.1_Silent_p.K463K|NFATC2_uc010zyx.1_Silent_p.K662K|NFATC2_uc010zyy.1_Silent_p.K463K|NFATC2_uc010zyz.1_Silent_p.K463K|NFATC2_uc002xwe.2_Silent_p.K662K	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	682					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					TGGGCTCCGTCTTGATGGCTG	0.612													0	0	0	0.038395	0	18	93										T	50049280	C	T	50049280	2	4	41	1	0	0	0	0	0	0	0	1	10362	912	32	1		1	NFATC2	20	50049280	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2314751	50049280	12976240	297	10715										
CASS4	57091	broad.mit.edu	37	chr20	55027048	55027048	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gaatcaaggccccacgctctCcccagttccagctccacttt	6	18	2	0	rs143746875		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:55027048C>G	uc002xxp.2	+	6	1041	c.816C>G	c.(814-816)CTC>CTG	p.L272L	CASS4_uc002xxq.3_Silent_p.L272L|CASS4_uc002xxr.2_Silent_p.L272L|CASS4_uc010zze.1_Silent_p.L218L|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	272					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CCCACGCTCTCCCCAGTTCCA	0.517													0	0	0	0.054565	0	33	49										G	55027048	C	G	55027048	2	3	41	1	0	0	0	0	0	0	0	1	2683	842	30	1		1	CASS4	20	55027048	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	4977768	55027048	7998472	298	10716										
RTEL1	51750	broad.mit.edu	37	chr20	62324319	62324319	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gccgcctgtctcggccccctCtttgctgaggaccccaagaa	10	17	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr20:62324319C>G	uc002yfu.1	+	29	3157	c.2814C>G	c.(2812-2814)CTC>CTG	p.L938L	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Silent_p.L938L|RTEL1_uc011abd.1_Silent_p.L962L|RTEL1_uc011abe.1_Silent_p.L715L|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Silent_p.L183L|TNFRSF6B_uc002yfy.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	938					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			TCGGCCCCCTCTTTGCTGAGG	0.657													0	0	0	0.048971	0	58	186										G	62324319	C	G	62324319	2	3	41	1	0	0	0	0	0	0	0	1	13720	900	32	1		1	RTEL1	20	62324319	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	7297271	62324319	701201	299	10717										
KRTAP13-1	140258	broad.mit.edu	37	chr21	31768802	31768802	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cttcagatccctgggttatgGaggctgtggcttcccttccc	11	13	1	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr21:31768802G>A	uc002yoa.2	+	1	411	c.398G>A	c.(397-399)GGA>GAA	p.G133E		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	133						intermediate filament				ovary(1)	1						CTGGGTTATGGAGGCTGTGGC	0.582													0	0	0	0.076483	0	23	12										A	31768802	G	A	31768802	3	1	41	1	0	0	0	0	1	0	0	0	8522	1174	41	1	400	1	KRTAP13-1	21	31768802	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		31768802	16361093	300	10718										
SYNJ1	8867	broad.mit.edu	37	chr21	34012014	34012014	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgatgttttgctttggctttCaggagtcagtcttccagcag	11	8	3	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr21:34012014C>T	uc002yqh.2	-	30	3781	c.3781G>A	c.(3781-3783)GAA>AAA	p.E1261K	SYNJ1_uc011ads.1_Missense_Mutation_p.E1175K|SYNJ1_uc002yqf.2_Missense_Mutation_p.E1206K|SYNJ1_uc002yqg.2_Missense_Mutation_p.E1175K|SYNJ1_uc002yqi.2_Missense_Mutation_p.E1261K|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1222	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						CTTTGGCTTTCAGGAGTCAGT	0.363													0	0	0	0.076483	0	21	54										T	34012014	C	T	34012014	3	4	41	1	0	0	0	0	1	0	0	0	15449	835	29	1	1094	1	SYNJ1	21	34012014	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2243212	34012014	14117881	301	10719										
IL10RB	3588	broad.mit.edu	37	chr21	34640751	34640751	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agaatgaattctgttaatttCaagaacattctacagtggga	8	5	3	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr21:34640751C>G	uc002yrk.1	+	2	201	c.102C>G	c.(100-102)TTC>TTG	p.F34L	IL10RB_uc002yrh.1_Missense_Mutation_p.F104L|IL10RB_uc002yri.1_Intron|uc002yrj.1_5'Flank|IL10RB_uc002yrl.1_Missense_Mutation_p.F36L	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	34	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						CTGTTAATTTCAAGAACATTC	0.418													0	0	0	0.0918	0	26	129										G	34640751	C	G	34640751	3	3	41	1	0	0	0	0	1	0	0	0	7621	825	29	1	108	1	IL10RB	21	34640751	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	628737	34640751	13489144	302	10720										
CLIC6	54102	broad.mit.edu	37	chr21	36079652	36079652	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atgattctctggctgaaaggCgttatatttaatgtgaccac	9	7	1	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr21:36079652C>T	uc010gmt.1	+	3	1503	c.1503C>T	c.(1501-1503)GGC>GGT	p.G501G	CLIC6_uc002yuf.1_Silent_p.G483G	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	501	Helical; Note=After insertion into the membrane; (Potential).					chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						GGCTGAAAGGCGTTATATTTA	0.393													0	0	0	0.048971	0	52	64										T	36079652	C	T	36079652	2	4	41	1	0	0	0	0	0	0	0	1	3530	755	27	2		2	CLIC6	21	36079652	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	1438901	36079652	12050243	303	10721										
TTC3	7267	broad.mit.edu	37	chr21	38538204	38538204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtcagattcatcttcagcaCcagcttttgaaaatgtgaaa	7	8	4	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr21:38538204C>T	uc002yvz.2	+	33	3793	c.3688C>T	c.(3688-3690)CCA>TCA	p.P1230S	TTC3_uc011aee.1_Missense_Mutation_p.P920S|TTC3_uc002ywa.2_Missense_Mutation_p.P1230S|TTC3_uc002ywb.2_Missense_Mutation_p.P1230S|TTC3_uc010gnf.2_Missense_Mutation_p.P995S|TTC3_uc002ywc.2_Missense_Mutation_p.P920S|TTC3_uc002ywd.1_Missense_Mutation_p.P294S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1230					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				ATCTTCAGCACCAGCTTTTGA	0.428													0	0	0	0.038147	0	7	38										T	38538204	C	T	38538204	3	4	41	1	0	0	0	0	1	0	0	0	16694	507	18	2	3814	2	TTC3	21	38538204	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2458552	38538204	9591691	304	10722										
DSCAM	1826	broad.mit.edu	37	chr21	41459119	41459119	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gtctttcatccatttgactgCaggagaagggtccccaacag	10	11	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr21:41459119C>T	uc002yyq.1	-	22	4398	c.3946G>A	c.(3946-3948)GCA>ACA	p.A1316T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1316	Extracellular (Potential).|Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CATTTGACTGCAGGAGAAGGG	0.473													0	0	0	0.062417	0	23	67										T	41459119	C	T	41459119	3	4	41	1	0	0	0	0	1	0	0	0	4768	710	25	2	2140	2	DSCAM	21	41459119	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2920915	41459119	6670776	305	10723										
MIF	4282	broad.mit.edu	37	chr22	24236667	24236667	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggtccttctgccatcatgccGatgttcatcgtaaacaccaa	7	13	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:24236667G>A	uc002zyr.1	+	1	103	c.6G>A	c.(4-6)CCG>CCA	p.P2P	MIF_uc011aje.1_Silent_p.P2P|uc002zys.1_3'UTR	NM_002415	NP_002406	P14174	MIF_HUMAN	macrophage migration inhibitory factor	2		Proton acceptor; via imino nitrogen.			cell proliferation|cell surface receptor linked signaling pathway|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of cell aging|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of gene expression|positive regulation of B cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase A signaling cascade|prostaglandin biosynthetic process|protein homotrimerization|regulation of macrophage activation	cell surface|cytoplasm|extracellular space	cell surface binding|chemoattractant activity|cytokine activity|cytokine receptor binding|dopachrome isomerase activity|phenylpyruvate tautomerase activity				0						CCATCATGCCGATGTTCATCG	0.687													0	0	0	0.037714	0	30	29										A	24236667	G	A	24236667	2	1	41	1	0	0	0	0	0	0	0	1	9583	1045	37	1		1	MIF	22	24236667	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		24236667	27067899	306	10724										
MYO18B	84700	broad.mit.edu	37	chr22	26422680	26422680	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ggaaaagctgcccagtccttCagcggccctctcggagttcg	12	14	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:26422680C>T	uc003abz.1	+	43	6990	c.6740C>T	c.(6739-6741)TCA>TTA	p.S2247L	MYO18B_uc003aca.1_Missense_Mutation_p.S2128L|MYO18B_uc010guy.1_Missense_Mutation_p.S2129L|MYO18B_uc010guz.1_Missense_Mutation_p.S2127L|MYO18B_uc011aka.1_Missense_Mutation_p.S1401L|MYO18B_uc011akb.1_Missense_Mutation_p.S1760L|MYO18B_uc010gva.1_Missense_Mutation_p.S230L|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2247						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCCAGTCCTTCAGCGGCCCTC	0.602													0	0	0	0.014758	0	4	27										T	26422680	C	T	26422680	3	4	41	1	0	0	0	0	1	0	0	0	10066	838	29	1	6906	1	MYO18B	22	26422680	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	2186013	26422680	24881886	307	10725										
SLC5A1	6523	broad.mit.edu	37	chr22	32480979	32480979	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ctaaagctgatgcccatgttCatcatggtgatgccaggaat	10	9	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:32480979C>T	uc003amc.2	+	9	1210	c.978C>T	c.(976-978)TTC>TTT	p.F326F	SLC5A1_uc011alz.1_Silent_p.F199F	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	326	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						TGCCCATGTTCATCATGGTGA	0.502													0	0	0	0.083992	0	25	86										T	32480979	C	T	32480979	2	4	41	1	0	0	0	0	0	0	0	1	14661	825	29	1		1	SLC5A1	22	32480979	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6058299	32480979	18823587	308	10726										
SYN3	8224	broad.mit.edu	37	chr22	32924939	32924939	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gagacaacaaggtcggccatCagctgtctgtcctcttccac	9	14	3	1	rs138034081		TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:32924939C>T	uc003amx.2	-	10	1311	c.1152G>A	c.(1150-1152)CTG>CTA	p.L384L	SYN3_uc003amy.2_Silent_p.L384L|SYN3_uc003amz.2_Silent_p.L383L|SYN3_uc011amc.1_Silent_p.L18L	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	384	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						GGTCGGCCATCAGCTGTCTGT	0.592											OREG0026488	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.055883	0	22	83										T	32924939	C	T	32924939	2	4	41	1	0	0	0	0	0	0	0	1	15439	813	29	1		1	SYN3	22	32924939	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	443960	32924939	18379627	309	10727										
APOL2	23780	broad.mit.edu	37	chr22	36624218	36624218	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttcaaccgaggaaactctttCaaaaaccactgcctgtgctg	7	12	3	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:36624218C>G	uc003aoz.2	-	5	582	c.246G>C	c.(244-246)TTG>TTC	p.L82F	APOL2_uc011amm.1_Missense_Mutation_p.L194F|APOL2_uc003apa.2_Missense_Mutation_p.L82F	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	82					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						GAAACTCTTTCAAAAACCACT	0.507													0	0	0	0.045515	0	41	139										G	36624218	C	G	36624218	3	3	41	1	0	0	0	0	1	0	0	0	806	825	29	1	771	1	APOL2	22	36624218	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3699279	36624218	14680348	310	10728										
APOL2	23780	broad.mit.edu	37	chr22	36624296	36624296	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	atgtgacttgcaagcttgttCagagctttacggagctcatc	10	9	2	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:36624296C>G	uc003aoz.2	-	5	504	c.168G>C	c.(166-168)CTG>CTC	p.L56L	APOL2_uc011amm.1_Silent_p.L168L|APOL2_uc003apa.2_Silent_p.L56L	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	56					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						CAAGCTTGTTCAGAGCTTTAC	0.453													0	0	0	0.048971	0	55	150										G	36624296	C	G	36624296	2	3	41	1	0	0	0	0	0	0	0	1	806	813	29	1		1	APOL2	22	36624296	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	78	36624296	14680270	311	10729										
GGA1	26088	broad.mit.edu	37	chr22	38010268	38010268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	gcttctgcgagcagctcaacGaggactttgaggggtaggtg	16	8	2	1			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:38010268G>A	uc003atc.2	+	2	480	c.115G>A	c.(115-117)GAG>AAG	p.E39K	GGA1_uc003atb.2_Missense_Mutation_p.E39K|GGA1_uc003atd.2_Missense_Mutation_p.E39K|GGA1_uc003ate.2_Missense_Mutation_p.E39K|GGA1_uc003atf.2_5'UTR	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	39	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					GCAGCTCAACGAGGACTTTGA	0.607													0	0	0	0.09319	0	13	42										A	38010268	G	A	38010268	3	1	41	1	0	0	0	0	1	0	0	0	6352	1059	37	1	121	1	GGA1	22	38010268	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	1385972	38010268	13294298	312	10730										
XPNPEP3	63929	broad.mit.edu	37	chr22	41322359	41322359	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	aggatgatgtagtggtgactCaggactcacctctcatcctt	10	10	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:41322359C>G	uc003azh.2	+	10	1536	c.1444C>G	c.(1444-1446)CAG>GAG	p.Q482E	XPNPEP3_uc003azi.2_Missense_Mutation_p.Q403E|XPNPEP3_uc011aoy.1_RNA	NM_022098	NP_071381	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3,	482					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0						AGTGGTGACTCAGGACTCACC	0.473													0	0	0	0.048971	0	59	120										G	41322359	C	G	41322359	3	3	41	1	0	0	0	0	1	0	0	0	17441	827	29	1	1482	1	XPNPEP3	22	41322359	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	3312091	41322359	9982207	313	10731										
EP300	2033	broad.mit.edu	37	chr22	41565561	41565561	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttcttccgtcctaaatgcttGaggactgcagtctatcatga	8	10	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chr22:41565561G>C	uc003azl.3	+	26	4622	c.4227G>C	c.(4225-4227)TTG>TTC	p.L1409F		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1409					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTAAATGCTTGAGGACTGCAG	0.323			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.058154	0	8	119										C	41565561	G	C	41565561	3	2	41	1	0	0	0	0	1	0	0	0	5148	1281	45	1	4329	1	EP300	22	41565561	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	243202	41565561	9739005	314	10732										
ATXN3L	92552	broad.mit.edu	37	chrX	13337636	13337636	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tgtatctgatattaattctgGacccgccaagagagaattca	8	8	3	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:13337636G>T	uc010ned.2	-	1	883	c.418C>A	c.(418-420)CCA>ACA	p.P140T		NM_001135995	NP_001129467	Q9H3M9	ATX3L_HUMAN	ataxin 3-like	140	Josephin.				protein deubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ubiquitin-specific protease activity			lung(2)|ovary(2)|large_intestine(1)|skin(1)	6						ATTAATTCTGGACCCGCCAAG	0.333													1	0	6.31663e-08	0.024245	6.50756e-08	14	7										T	13337636	G	T	13337636	3	4	41	1	0	0	0	0	1	0	0	0	1214	1174	41	3	653	3	ATXN3L	23	13337636	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08		13337636	141932924	315	10733										
CXorf23	256643	broad.mit.edu	37	chrX	19947930	19947930	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	tttctcattaatctttctctGaacttatgagtgataaatcc	4	8	3	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:19947930G>A	uc004czp.2	-	10	1992	c.1992C>T	c.(1990-1992)TTC>TTT	p.F664F	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Intron|CXorf23_uc004czo.2_Silent_p.F643F	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	693						mitochondrion				lung(1)|skin(1)	2						ATCTTTCTCTGAACTTATGAG	0.333													0	0	0	0.048971	0	76	17										A	19947930	G	A	19947930	2	1	41	1	0	0	0	0	0	0	0	1	4103	1281	45	1		1	CXorf23	23	19947930	Silent	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	6610294	19947930	135322630	316	10734										
DGKK	139189	broad.mit.edu	37	chrX	50121635	50121635	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cattgccatctgcacagaacCaaagattgccaccacctcca	5	16	1	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:50121635C>A	uc010njr.1	-	21	2977	c.2917G>T	c.(2917-2919)GGT>TGT	p.G973C		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	973					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TGCACAGAACCAAAGATTGCC	0.537													1	0	6.4e-05	0.004672	6.49529e-05	3	2										A	50121635	C	A	50121635	3	1	41	1	0	0	0	0	1	0	0	0	4472	594	21	4	929	4	DGKK	23	50121635	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	30173705	50121635	105148925	317	10735										
MAGED2	10916	broad.mit.edu	37	chrX	54841756	54841756	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	cggatttgaaggctgcagctGaggctgcagctgaagccaag	15	9	0	3			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:54841756G>T	uc004dtk.1	+	12	1556	c.1462G>T	c.(1462-1464)GAG>TAG	p.E488*	MAGED2_uc004dtl.1_Nonsense_Mutation_p.E488*|MAGED2_uc004dtm.1_Nonsense_Mutation_p.E403*|MAGED2_uc010nkc.1_Intron|MAGED2_uc004dtn.1_Nonsense_Mutation_p.E488*|MAGED2_uc004dto.1_Nonsense_Mutation_p.E462*	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	488										ovary(2)|breast(1)	3						ggctgcagctgaggctgcagc	0.478													1	0	9.62906e-15	0.086207	1.01241e-14	36	11										T	54841756	G	T	54841756	4	4	41	1	0	0	0	0	0	1	0	0	9184	1291	45	3	1504	3	MAGED2	23	54841756	Nonsense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	4720121	54841756	100428804	318	10736										
ZC4H2	55906	broad.mit.edu	37	chrX	64139077	64139077	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ccattctgctttctgcttctCaaagtaactttggagatgag	8	9	3	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:64139077C>T	uc004dvu.2	-	4	494	c.406G>A	c.(406-408)GAG>AAG	p.E136K	ZC4H2_uc004dvv.2_Missense_Mutation_p.E113K|ZC4H2_uc011mov.1_Missense_Mutation_p.E113K|ZC4H2_uc011mow.1_Intron|ZC4H2_uc004dvw.1_3'UTR	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	136							metal ion binding|protein binding			ovary(1)	1						TTCTGCTTCTCAAAGTAACTT	0.532													0	0	0	0.069288	0	22	9										T	64139077	C	T	64139077	3	4	41	1	0	0	0	0	1	0	0	0	17575	835	29	1	295	1	ZC4H2	23	64139077	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	9297321	64139077	91131483	319	10737										
PCDH19	57526	broad.mit.edu	37	chrX	99663458	99663458	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	agcgcgaagcccgcctctcgCgcgtctttggccacgttggc	13	16	2	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:99663458C>T	uc010nmz.2	-	1	1814	c.138G>A	c.(136-138)GCG>GCA	p.A46A	PCDH19_uc004efw.3_Silent_p.A46A|PCDH19_uc004efx.3_Silent_p.A46A	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	46	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CCGCCTCTCGCGCGTCTTTGG	0.632													0	0	0	0.058154	0	8	8										T	99663458	C	T	99663458	2	4	41	1	0	0	0	0	0	0	0	1	11514	755	27	2		2	PCDH19	23	99663458	Silent	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	35524381	99663458	55607102	320	10738										
TBC1D8B	54885	broad.mit.edu	37	chrX	106082551	106082551	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	ttttcagcttgctattagttCtgagtctacagagccatctg	8	9	4	2			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:106082551C>T	uc004emo.2	+	8	1382	c.1217C>T	c.(1216-1218)TCT>TTT	p.S406F	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Missense_Mutation_p.S406F	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	406						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GCTATTAGTTCTGAGTCTACA	0.348													0	0	0	0.049695	0	18	22										T	106082551	C	T	106082551	3	4	41	1	0	0	0	0	1	0	0	0	15623	913	32	1	1247	1	TBC1D8B	23	106082551	Missense_Mutation	SNP	C	TCGA-DK-A1A5-01A-11D-A13W-08	6419093	106082551	49188009	321	10739										
ABCD1	215	broad.mit.edu	37	chrX	152991184	152991184	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.53416149068323	172	1.75606639598649e-63	3.94959878251245	4.71585239085239	3.4402924919392	0.467727655690366	0.68256875146656	128	acagtgccatccgttacctgGagggccaactggccctgtcg	12	14	0	0			TCGA-DK-A1A5-01A-11D-A13W-08	TCGA-DK-A1A5-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	448fe471-3f4e-4dc8-a4e0-6f147dc93abe	68402877-a578-4bfd-a05e-58c6e06fb6a3	g.chrX:152991184G>A	uc004fif.2	+	1	862	c.463G>A	c.(463-465)GAG>AAG	p.E155K	BCAP31_uc004fid.2_5'Flank|BCAP31_uc011myz.1_5'Flank|BCAP31_uc011mza.1_5'Flank|BCAP31_uc004fie.2_5'Flank	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	155	ABC transmembrane type-1.|Interaction with PEX19.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGTTACCTGGAGGGCCAACT	0.642													0	0	0	0.041601	0	31	7										A	152991184	G	A	152991184	3	1	41	1	0	0	0	0	1	0	0	0	60	1175	41	1	465	1	ABCD1	23	152991184	Missense_Mutation	SNP	G	TCGA-DK-A1A5-01A-11D-A13W-08	46908633	152991184	2279376	322	10740										
ACAP3	116983	broad.mit.edu	37	chr1	1235416	1235416	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aggctgtagccctgctggaaGaagctggactgggcgtgcat	16	9	0	1	rs147197474	byFrequency	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:1235416G>T	uc001aeb.2	-	8	674	c.600C>A	c.(598-600)TTC>TTA	p.F200L	ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Missense_Mutation_p.F158L|ACAP3_uc001aec.1_Missense_Mutation_p.F158L	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	200					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						CCTGCTGGAAGAAGCTGGACT	0.657													1	0	6.17242e-35	0.01441	6.65509e-35	49	64										T	1235416	G	T	1235416	3	4	42	1	0	0	0	0	1	0	0	0	120	933	33	3	1972	3	ACAP3	1	1235416	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		1235416	248015205	1	10741										
MEGF6	1953	broad.mit.edu	37	chr1	3425647	3425647	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcccgcgctcaccaaacttcTctgtgagcgtgtgttcgccc	10	16	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:3425647T>C	uc001akl.2	-	12	1747	c.1520A>G	c.(1519-1521)GAG>GGG	p.E507G	MEGF6_uc001akk.2_Missense_Mutation_p.E402G	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	507						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		ACCAAACTTCTCTGTGAGCGT	0.672													0	0	0	0.010729	0	11	29										C	3425647	T	C	3425647	3	2	42	1	0	0	0	0	1	0	0	0	9462	1551	54	5	3209	5	MEGF6	1	3425647	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	2190231	3425647	245824974	2	10742										
CASZ1	54897	broad.mit.edu	37	chr1	10720282	10720282	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gggcagccgcaggccgggcaGggtgcccaccacctccttgc	15	17	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:10720282G>A	uc001aro.2	-	6	1137	c.817C>T	c.(817-819)CTG>TTG	p.L273L	CASZ1_uc001arp.1_Silent_p.L273L|CASZ1_uc009vmx.2_Silent_p.L297L|CASZ1_uc001arq.1_Silent_p.L132L	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	273				L -> P (in Ref. 2; ABB29845).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AGGCCGGGCAGGGTGCCCACC	0.687													0	0	0	0.01441	0	110	106										A	10720282	G	A	10720282	2	1	42	1	0	0	0	0	0	0	0	1	2685	991	35	2		2	CASZ1	1	10720282	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	7294635	10720282	238530339	3	10743										
ARHGEF19	128272	broad.mit.edu	37	chr1	16532689	16532689	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttcacctctcgctggtgctCttgacctcgggcagtttgga	11	13	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:16532689C>G	uc001ayc.1	-	7	1421	c.1284G>C	c.(1282-1284)AAG>AAC	p.K428N	ARHGEF19_uc009voo.1_5'UTR|ARHGEF19_uc001ayb.1_5'UTR	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	428	DH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTGGTGCTCTTGACCTCGG	0.637													0	0	0	0.006122	0	17	9										G	16532689	C	G	16532689	3	3	42	1	0	0	0	0	1	0	0	0	902	912	32	1	1164	1	ARHGEF19	1	16532689	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	5812407	16532689	232717932	4	10744										
DHDDS	79947	broad.mit.edu	37	chr1	26772806	26772806	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgcctcttttccctgatcaGggagaaactgcagaagcatg	10	11	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:26772806G>A	uc001bml.2	+	5	445	c.324_splice	c.e5-1	p.K108_splice	DHDDS_uc001bmk.2_Splice_Site_p.K108_splice|DHDDS_uc001bmm.2_Splice_Site_p.K15_splice|DHDDS_uc001bmn.2_Intron|DHDDS_uc010ofd.1_Splice_Site_p.K108_splice	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b								protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		TCCCTGATCAGGGAGAAACTG	0.483													0	0	0	0.001855	0	13	61										A	26772806	G	A	26772806	5	1	42	1	0	0	0	0	0	0	1	0	4478	1014	35	2	337	2	DHDDS	1	26772806	Splice_Site	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10240117	26772806	222477815	5	10745										
EPB41	2035	broad.mit.edu	37	chr1	29438879	29438879	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acatcttctctttggttccaGactgtaaaaggtgggatttc	9	8	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:29438879G>C	uc001brm.1	+	18	2423	c.2416_splice	c.e18-1	p.T806_splice	EPB41_uc001brg.1_Splice_Site_p.T583_splice|EPB41_uc001brh.1_Splice_Site_p.T530_splice|EPB41_uc001bri.1_Splice_Site_p.T717_splice|EPB41_uc001brj.1_Splice_Site_p.T543_splice|EPB41_uc001brl.1_Splice_Site_p.T773_splice|EPB41_uc009vtl.1_Splice_Site_p.T500_splice|EPB41_uc009vtm.1_Splice_Site_p.T385_splice|EPB41_uc009vtn.1_Splice_Site	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1						blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		TTTGGTTCCAGACTGTAAAAG	0.299													0	0	0	0.005524	0	35	95										C	29438879	G	C	29438879	5	2	42	1	0	0	0	0	0	0	1	0	5151	956	33	1	2506	1	EPB41	1	29438879	Splice_Site	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2666073	29438879	219811742	6	10746										
SFPQ	6421	broad.mit.edu	37	chr1	35656103	35656103	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtttaatcaatcttacttttGatacattggattcttctggg	7	6	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:35656103G>A	uc001bys.2	-	4	1504	c.1411C>T	c.(1411-1413)CAA>TAA	p.Q471*	SFPQ_uc001byr.2_RNA	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	471					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TCTTACTTTTGATACATTGGA	0.308			T	TFE3	papillary renal cell								0	0	0	0.00245	0	14	12										A	35656103	G	A	35656103	4	1	42	1	0	0	0	0	0	1	0	0	14160	1299	45	1	740	1	SFPQ	1	35656103	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	6217224	35656103	213594518	7	10747										
KIAA0319L	79932	broad.mit.edu	37	chr1	35915495	35915495	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cacctccacagtggtccggtCtgtgtcactctcaccctttg	8	16	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:35915495C>G	uc001byx.2	-	15	2584	c.2326G>C	c.(2326-2328)GAC>CAC	p.D776H	KIAA0319L_uc001byw.2_Missense_Mutation_p.D218H|KIAA0319L_uc010ohv.1_Missense_Mutation_p.D418H	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	776	PKD 5.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGGTCCGGTCTGTGTCACTC	0.483													0	0	0	0.009535	0	31	49										G	35915495	C	G	35915495	3	3	42	1	0	0	0	0	1	0	0	0	8169	913	32	1	851	1	KIAA0319L	1	35915495	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	259392	35915495	213335126	8	10748										
SLC2A1	6513	broad.mit.edu	37	chr1	43394663	43394663	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gccatgccagcgaggcctatGaggtgcagggtccgccggcc	16	14	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:43394663G>A	uc001cik.2	-	8	1539	c.1014C>T	c.(1012-1014)CTC>CTT	p.L338L		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	338	Helical; Name=9; (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGAGGCCTATGAGGTGCAGGG	0.622													0	0	0	0.01441	0	50	120										A	43394663	G	A	43394663	2	1	42	1	0	0	0	0	0	0	0	1	14538	1277	45	1		1	SLC2A1	1	43394663	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	7479168	43394663	205855958	9	10749										
ELAVL4	1996	broad.mit.edu	37	chr1	50642818	50642818	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tccaaaggatgcagagaaagCcatcaacactttaaatggac	8	9	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:50642818C>T	uc001csb.2	+	3	576	c.308C>T	c.(307-309)GCC>GTC	p.A103V	ELAVL4_uc001cry.3_Missense_Mutation_p.A106V|ELAVL4_uc001crz.3_Missense_Mutation_p.A103V|ELAVL4_uc001csa.3_Missense_Mutation_p.A120V|ELAVL4_uc001csc.3_Missense_Mutation_p.A103V|ELAVL4_uc009vyu.2_Missense_Mutation_p.A108V|ELAVL4_uc010omz.1_Missense_Mutation_p.A108V	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	103	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GCAGAGAAAGCCATCAACACT	0.343													0	0	0	0.010504	0	19	47										T	50642818	C	T	50642818	3	4	42	1	0	0	0	0	1	0	0	0	5052	739	26	2	417	2	ELAVL4	1	50642818	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	7248155	50642818	198607803	10	10750										
C1orf177	163747	broad.mit.edu	37	chr1	55277826	55277826	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gacactttctctggtgatcgGagcaagccactgccttatgg	11	11	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:55277826G>C	uc001cyb.3	+	6	780	c.726G>C	c.(724-726)CGG>CGC	p.R242R	C1orf177_uc001cya.3_Silent_p.R242R	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	242											0						CTGGTGATCGGAGCAAGCCAC	0.577													0	0	0	0.004656	0	24	49										C	55277826	G	C	55277826	2	2	42	1	0	0	0	0	0	0	0	1	2017	1161	41	1		1	C1orf177	1	55277826	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	4635008	55277826	193972795	11	10751										
TYW3	127253	broad.mit.edu	37	chr1	75229767	75229767	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gatgatgatgatctaggaatCaatgttaccatcttccctga	8	8	3	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:75229767C>G	uc001dgn.2	+	6	839	c.750C>G	c.(748-750)ATC>ATG	p.I250M	TYW3_uc010oqw.1_Missense_Mutation_p.I217M|TYW3_uc010oqx.1_Missense_Mutation_p.I166M|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	250					tRNA processing		methyltransferase activity			ovary(2)	2						ATCTAGGAATCAATGTTACCA	0.348													0	0	0	0.007413	0	16	178										G	75229767	C	G	75229767	3	3	42	1	0	0	0	0	1	0	0	0	16817	816	29	1	772	1	TYW3	1	75229767	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	19951941	75229767	174020854	12	10752										
AGL	178	broad.mit.edu	37	chr1	100349714	100349714	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcttgaagctagaactattGagagaaacacgaaaccttat	7	7	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:100349714G>C	uc001dsi.1	+	18	2747	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q	AGL_uc001dsj.1_Missense_Mutation_p.E783Q|AGL_uc001dsk.1_Missense_Mutation_p.E783Q|AGL_uc001dsl.1_Missense_Mutation_p.E783Q|AGL_uc001dsm.1_Missense_Mutation_p.E767Q|AGL_uc001dsn.1_Missense_Mutation_p.E766Q	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	783	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAGAACTATTGAGAGAAACAC	0.328													0	0	0	0.007835	0	41	36										C	100349714	G	C	100349714	3	2	42	1	0	0	0	0	1	0	0	0	384	1291	45	1	2482	1	AGL	1	100349714	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	25119947	100349714	148900907	13	10753										
CCDC76	54482	broad.mit.edu	37	chr1	100613733	100613733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttccattatttccagcgaatGagtagttgggcaacttgtgg	11	7	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:100613733G>C	uc001dsv.2	+	10	1120	c.1101G>C	c.(1099-1101)ATG>ATC	p.M367I	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	367					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		TCCAGCGAATGAGTAGTTGGG	0.433													0	0	0	0.011902	0	44	48										C	100613733	G	C	100613733	3	2	42	1	0	0	0	0	1	0	0	0	2850	1290	45	1	1139	1	CCDC76	1	100613733	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	264019	100613733	148636888	14	10754										
AMY2A	279	broad.mit.edu	37	chr1	104160108	104160108	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccattgggttctgctgggctCagtattccccaaatacacaa	8	12	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:104160108C>T	uc001dut.2	+	1	110	c.46C>T	c.(46-48)CAG>TAG	p.Q16*	AMY2A_uc010ouq.1_Nonsense_Mutation_p.Q16*	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	16					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	CTGCTGGGCTCAGTATTCCCC	0.398													0	0	0	0.01441	0	40	160										T	104160108	C	T	104160108	4	4	42	1	0	0	0	0	0	1	0	0	594	827	29	1	48	1	AMY2A	1	104160108	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3546375	104160108	145090513	15	10755										
OVGP1	5016	broad.mit.edu	37	chr1	111966266	111966266	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atcaaagtcatgtgtcctcaGaagggatataactgaagcaa	9	7	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:111966266G>A	uc001eba.2	-	5	438	c.382C>T	c.(382-384)CTG>TTG	p.L128L	OVGP1_uc001eaz.2_Silent_p.L90L|OVGP1_uc010owb.1_5'UTR|OVGP1_uc010owc.1_Silent_p.L118L	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	128					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TGTGTCCTCAGAAGGGATATA	0.433													0	0	0	0.013114	0	47	48										A	111966266	G	A	111966266	2	1	42	1	0	0	0	0	0	0	0	1	11325	933	33	1		1	OVGP1	1	111966266	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	7806158	111966266	137284355	16	10756										
ADAM30	11085	broad.mit.edu	37	chr1	120437228	120437228	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagattttctgcctgtaaatGagtagaaattatagtcgtat	9	4	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:120437228G>C	uc001eij.2	-	1	1886	c.1732C>G	c.(1732-1734)CAT>GAT	p.H578D		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	578	Cys-rich.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GCCTGTAAATGAGTAGAAATT	0.408													0	0	0	0.01441	0	76	79										C	120437228	G	C	120437228	3	2	42	1	0	0	0	0	1	0	0	0	248	1290	45	1	644	1	ADAM30	1	120437228	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	8470962	120437228	128813393	17	10757										
TXNIP	10628	broad.mit.edu	37	chr1	145440778	145440779	+	Frame_Shift_Ins	INS	-	-	A													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tagatctgaacatccctgatINSaccccagaaggtgagccaga							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:145440778_145440779insA	uc001enn.3	+	6	1319_1320	c.978_979insA	c.(976-981)GATACCfs	p.D326fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Ins_p.D271fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	326_327					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACATCCCTGATACCCCAGAAGG	0.48																		34	140	---	---								A	145440779	-	A	145440778	7	5	42	1	0	1	1	0	0	0	0	0	16800	1403	49	0	1000	0	TXNIP	1	145440778	Frame_Shift_Ins	INS	-	TCGA-DK-A1A6-01A-11D-A13W-08	25003550	145440778	103809843	18	10758										
GPR89A	653519	broad.mit.edu	37	chr1	145771670	145771670	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagataattcacagtgatctCaatgcctcttgtgacaggat	8	9	3	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:145771670C>T	uc001eot.2	-	11	1144	c.970G>A	c.(970-972)GAG>AAG	p.E324K	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Missense_Mutation_p.E22K|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Missense_Mutation_p.E248K|GPR89A_uc010ozb.1_Missense_Mutation_p.E299K|GPR89A_uc001eos.2_Missense_Mutation_p.E204K|GPR89A_uc010ozc.1_Missense_Mutation_p.E299K|GPR89A_uc010ozd.1_Missense_Mutation_p.E271K|GPR89A_uc010oze.1_Missense_Mutation_p.E324K	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	324					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			ACAGTGATCTCAATGCCTCTT	0.363													0	0	0	0.003755	0	24	72										T	145771670	C	T	145771670	3	4	42	1	0	0	0	0	1	0	0	0	6718	835	29	1	413	1	GPR89A	1	145771670	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	330892	145771670	103478951	19	10759										
GPR89A	653519	broad.mit.edu	37	chr1	145771715	145771715	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tttcccaactcgatcaaaaaCaatattgatggtagcctgca	6	10	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:145771715C>G	uc001eot.2	-	11	1099	c.925G>C	c.(925-927)GTT>CTT	p.V309L	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Missense_Mutation_p.V7L|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Missense_Mutation_p.V233L|GPR89A_uc010ozb.1_Missense_Mutation_p.V284L|GPR89A_uc001eos.2_Missense_Mutation_p.V189L|GPR89A_uc010ozc.1_Missense_Mutation_p.V284L|GPR89A_uc010ozd.1_Missense_Mutation_p.V256L|GPR89A_uc010oze.1_Missense_Mutation_p.V309L	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	309	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CGATCAAAAACAATATTGATG	0.353													0	0	0	0.005443	0	21	60										G	145771715	C	G	145771715	3	3	42	1	0	0	0	0	1	0	0	0	6718	478	17	4	458	4	GPR89A	1	145771715	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	45	145771715	103478906	20	10760										
ARNT	405	broad.mit.edu	37	chr1	150795814	150795814	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acagcacttggccttttaatTtcactacctgaaaaagtttt	5	9	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:150795814T>C	uc001evr.1	-	14	1393	c.1250A>G	c.(1249-1251)AAA>AGA	p.K417R	ARNT_uc001evs.1_Missense_Mutation_p.K402R|ARNT_uc009wmb.1_Missense_Mutation_p.K403R|ARNT_uc009wmc.1_Missense_Mutation_p.K417R|ARNT_uc009wmd.1_Missense_Mutation_p.K402R|ARNT_uc009wme.1_Intron|ARNT_uc010pcl.1_Missense_Mutation_p.K401R	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	417	PAS 2.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCTTTTAATTTCACTACCTG	0.368			T	ETV6	AML								0	0	0	0.01441	0	69	61										C	150795814	T	C	150795814	3	2	42	1	0	0	0	0	1	0	0	0	965	1841	64	5	1155	5	ARNT	1	150795814	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	5024099	150795814	98454807	21	10761										
C1orf56	54964	broad.mit.edu	37	chr1	151022921	151022921	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttttcttacgcagatagacaGaaaccagaggtaatggccac	9	9	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:151022921G>A	uc001ewn.2	+	2	1078	c.1013G>A	c.(1012-1014)AGA>AAA	p.R338K		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	338						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGATAGACAGAAACCAGAGG	0.413													0	0	0	0.004878	0	34	133										A	151022921	G	A	151022921	3	1	42	1	0	0	0	0	1	0	0	0	2048	942	33	1	1019	1	C1orf56	1	151022921	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	227107	151022921	98227700	22	10762										
FLG	2312	broad.mit.edu	37	chr1	152276031	152276031	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagtgtccagacctatctacCgattgctcgtggtaggatcc	11	11	1	1	rs147295587	by1000genomes	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:152276031C>T	uc001ezu.1	-	3	11367	c.11331G>A	c.(11329-11331)TCG>TCA	p.S3777S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3777	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTATCTACCGATTGCTCGT	0.587									Ichthyosis				0	0	0	0.01441	0	140	467										T	152276031	C	T	152276031	2	4	42	1	0	0	0	0	0	0	0	1	5922	639	23	2		2	FLG	1	152276031	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1253110	152276031	96974590	23	10763										
FLG	2312	broad.mit.edu	37	chr1	152277865	152277865	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcctgattgttcctcattaCgtgttgttctgcttgcactt	7	11	2	1	rs145566935		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:152277865C>T	uc001ezu.1	-	3	9533	c.9497G>A	c.(9496-9498)CGT>CAT	p.R3166H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3166	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCATTACGTGTTGTTCT	0.552									Ichthyosis				0	0	0	0.01441	0	103	360										T	152277865	C	T	152277865	3	4	42	1	0	0	0	0	1	0	0	0	5922	536	19	2	2692	2	FLG	1	152277865	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1834	152277865	96972756	24	10764										
CRTC2	200186	broad.mit.edu	37	chr1	153920995	153920995	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgggtcaagttctggtggttGaaggtgtggggatcctgggg	20	4	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:153920995G>A	uc010ped.1	-	13	1870	c.1800C>T	c.(1798-1800)TTC>TTT	p.F600F	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Silent_p.F136F	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	600					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCTGGTGGTTGAAGGTGTGGG	0.592													0	0	0	0.01441	0	116	109										A	153920995	G	A	153920995	2	1	42	1	0	0	0	0	0	0	0	1	3900	1281	45	1		1	CRTC2	1	153920995	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1643130	153920995	95329626	25	10765										
INSRR	3645	broad.mit.edu	37	chr1	156823546	156823546	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttctgtgccagtgcccacctCtctggcagtggctggaggtc	13	13	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:156823546C>G	uc010pht.1	-	2	889	c.635G>C	c.(634-636)AGA>ACA	p.R212T	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.R212T	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	212					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGCCCACCTCTCTGGCAGTG	0.607													0	0	0	0.00874	0	35	132										G	156823546	C	G	156823546	3	3	42	1	0	0	0	0	1	0	0	0	7774	913	32	1	3341	1	INSRR	1	156823546	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2902551	156823546	92427075	26	10766										
CRP	1401	broad.mit.edu	37	chr1	159683510	159683510	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttccttcaaagttcccaccGaaggaatcctgctcctgccc	6	17	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:159683510G>A	uc001ftw.2	-	2	584	c.480C>T	c.(478-480)TTC>TTT	p.F160F	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	160	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AGTTCCCACCGAAGGAATCCT	0.517													0	0	0	0.01441	0	116	250										A	159683510	G	A	159683510	2	1	42	1	0	0	0	0	0	0	0	1	3895	1049	37	1		1	CRP	1	159683510	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2859964	159683510	89567111	27	10767										
C1orf114	57821	broad.mit.edu	37	chr1	169394120	169394120	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtccttttcaaagtcatcttCgtattcttcacttttctttg	4	10	6	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:169394120C>T	uc001gga.1	-	2	214	c.46G>A	c.(46-48)GAA>AAA	p.E16K	C1orf114_uc001gfz.1_Missense_Mutation_p.E16K|C1orf114_uc009wvq.1_Missense_Mutation_p.E16K|C1orf114_uc001ggb.2_Missense_Mutation_p.E16K|C1orf114_uc001ggc.1_Missense_Mutation_p.E16K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	16											0	all_hematologic(923;0.208)					AAGTCATCTTCGTATTCTTCA	0.289													0	0	0	0.008871	0	17	43										T	169394120	C	T	169394120	3	4	42	1	0	0	0	0	1	0	0	0	1987	893	31	1	1500	1	C1orf114	1	169394120	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	9710610	169394120	79856501	28	10768										
F5	2153	broad.mit.edu	37	chr1	169511937	169511937	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtggcttgttggtgagaaggGgctttctgaggttctgcaag	17	5	2	2	rs139113111		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:169511937G>C	uc001ggg.1	-	13	2536	c.2391C>G	c.(2389-2391)GCC>GCG	p.A797A		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	797	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GGTGAGAAGGGGCTTTCTGAG	0.433													0	0	0	0.00874	0	41	114										C	169511937	G	C	169511937	2	2	42	1	0	0	0	0	0	0	0	1	5348	1219	43	4		4	F5	1	169511937	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	117817	169511937	79738684	29	10769										
LAMC1	3915	broad.mit.edu	37	chr1	183096378	183096378	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagcctgtgactgtcatcctGagggatctctttcacttcag	9	12	4	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:183096378G>A	uc001gpy.3	+	17	3219	c.2962G>A	c.(2962-2964)GAG>AAG	p.E988K		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	988	Laminin EGF-like 11.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCATCCTGAGGGATCTCT	0.378													0	0	0	0.001855	0	13	36										A	183096378	G	A	183096378	3	1	42	1	0	0	0	0	1	0	0	0	8614	1291	45	1	3028	1	LAMC1	1	183096378	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	13584441	183096378	66154243	30	10770										
CNTN2	6900	broad.mit.edu	37	chr1	205042279	205042279	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gaaatcccagtgcctgaagaCattggccatgccctggtaca	10	12	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:205042279C>T	uc001hbr.2	+	22	3197	c.2928C>T	c.(2926-2928)GAC>GAT	p.D976D	CNTN2_uc001hbs.2_Silent_p.D764D	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	976	Fibronectin type-III 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGCCTGAAGACATTGGCCATG	0.567													0	0	0	0.008361	0	30	40										T	205042279	C	T	205042279	2	4	42	1	0	0	0	0	0	0	0	1	3641	477	17	2		2	CNTN2	1	205042279	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	21945901	205042279	44208342	31	10771										
RAB3GAP2	25782	broad.mit.edu	37	chr1	220364531	220364531	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agctactcgacttggaccctGagaatttccaaagggggaaa	11	9	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:220364531G>A	uc010puk.1	-	14	1530	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Nonsense_Mutation_p.Q36*	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	456					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CTTGGACCCTGAGAATTTCCA	0.478													0	0	0	0.00632	0	28	51										A	220364531	G	A	220364531	4	1	42	1	0	0	0	0	0	1	0	0	12936	1299	45	1	2903	1	RAB3GAP2	1	220364531	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	15322252	220364531	28886090	32	10772										
KIAA1804	84451	broad.mit.edu	37	chr1	233489599	233489599	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcaccggagaagtcccctatCggggcattgatggcctcgcc	12	14	1	2	rs145103476		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:233489599C>T	uc001hvt.3	+	3	1294	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	KIAA1804_uc001hvs.1_Missense_Mutation_p.R345W	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	345	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				AGTCCCCTATCGGGGCATTGA	0.507													0	0	0	0.006122	0	19	77										T	233489599	C	T	233489599	3	4	42	1	0	0	0	0	1	0	0	0	8259	875	31	1	1043	1	KIAA1804	1	233489599	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	13125068	233489599	15761022	33	10773										
RYR2	6262	broad.mit.edu	37	chr1	237813229	237813229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cctcaatcggtacctttgcaCagccgtcttgccattgttaa	7	13	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:237813229C>T	uc001hyl.1	+	50	7685	c.7565C>T	c.(7564-7566)ACA>ATA	p.T2522I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2522	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TACCTTTGCACAGCCGTCTTG	0.463													0	0	0	0.010771	0	43	133										T	237813229	C	T	237813229	3	4	42	1	0	0	0	0	1	0	0	0	13769	478	17	2	7763	2	RYR2	1	237813229	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4323630	237813229	11437392	34	10774										
ZP4	57829	broad.mit.edu	37	chr1	238053778	238053778	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	taccccaagctattagtacaGgaggagacgttgcctcctgg	11	11	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:238053778G>A	uc001hym.2	-	1	158	c.158C>T	c.(157-159)CCT>CTT	p.P53L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	53	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TATTAGTACAGGAGGAGACGT	0.488													0	0	0	0.013537	0	10	48										A	238053778	G	A	238053778	3	1	42	1	0	0	0	0	1	0	0	0	18215	1000	35	2	1512	2	ZP4	1	238053778	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	240549	238053778	11196843	35	10775										
ADSS	159	broad.mit.edu	37	chr1	244582145	244582145	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atacacttctccaacattttGaggtggcatacccaaaccag	6	12	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:244582145G>C	uc001iaj.2	-	9	1156	c.862C>G	c.(862-864)CAA>GAA	p.Q288E		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	288					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CCAACATTTTGAGGTGGCATA	0.378													0	0	0	0.006214	0	9	31										C	244582145	G	C	244582145	3	2	42	1	0	0	0	0	1	0	0	0	347	1299	45	1	528	1	ADSS	1	244582145	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	6528367	244582145	4668476	36	10776										
MYT1L	23040	broad.mit.edu	37	chr2	1926269	1926269	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aggttccccttggtcatgtcGaacacctcttcagacctgtc	8	14	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:1926269G>T	uc002qxe.2	-	10	2099	c.1272C>A	c.(1270-1272)TTC>TTA	p.F424L	MYT1L_uc002qxd.2_Missense_Mutation_p.F424L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	424					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGGTCATGTCGAACACCTCTT	0.567													1	0	1.85244e-09	0.00333	1.92434e-09	24	121										T	1926269	G	T	1926269	3	4	42	1	0	0	0	0	1	0	0	0	10107	1049	37	3	2346	3	MYT1L	2	1926269	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		1926269	241273104	37	10777										
APOB	338	broad.mit.edu	37	chr2	21230048	21230048	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atttttcagctttgtacttaTcaaacttaatttttgtttca	3	6	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:21230048T>C	uc002red.2	-	26	9820	c.9692A>G	c.(9691-9693)GAT>GGT	p.D3231G		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3231	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTGTACTTATCAAACTTAAT	0.368													0	0	0	0.004482	0	9	39										C	21230048	T	C	21230048	3	2	42	1	0	0	0	0	1	0	0	0	785	1435	50	5	4015	5	APOB	2	21230048	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	19303779	21230048	221969325	38	10778										
LTBP1	4052	broad.mit.edu	37	chr2	33568000	33568000	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcctctgttatcagggctttCaagccccacaggatgggcaa	11	12	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:33568000C>G	uc002ros.2	+	25	3829	c.3829C>G	c.(3829-3831)CAA>GAA	p.Q1277E	LTBP1_uc002rot.2_Missense_Mutation_p.Q951E|LTBP1_uc002rou.2_Missense_Mutation_p.Q950E|LTBP1_uc002rov.2_Missense_Mutation_p.Q897E|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1276	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCAGGGCTTTCAAGCCCCACA	0.458													0	0	0	0.00499	0	18	59										G	33568000	C	G	33568000	3	3	42	1	0	0	0	0	1	0	0	0	9073	827	29	1	3979	1	LTBP1	2	33568000	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	12337952	33568000	209631373	39	10779										
MTIF2	4528	broad.mit.edu	37	chr2	55476578	55476578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aacatcacctccataatcttCacataccacatcgtaagcca	2	15	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:55476578C>T	uc002ryn.2	-	10	1671	c.934G>A	c.(934-936)GAA>AAA	p.E312K	MTIF2_uc010yox.1_5'UTR|MTIF2_uc002ryo.2_Missense_Mutation_p.E312K	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	312	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						CCATAATCTTCACATACCACA	0.433													0	0	0	0.008871	0	20	79										T	55476578	C	T	55476578	3	4	42	1	0	0	0	0	1	0	0	0	9934	835	29	1	1281	1	MTIF2	2	55476578	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	21908578	55476578	187722795	40	10780										
SMEK2	57223	broad.mit.edu	37	chr2	55825620	55825620	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagagtagaaagaaaattctCttcaaaaacagatggtgtgg	10	4	2	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:55825620C>G	uc002rzc.2	-	4	1228	c.853G>C	c.(853-855)GAG>CAG	p.E285Q	SMEK2_uc002rzb.2_Missense_Mutation_p.E285Q|SMEK2_uc002rzd.2_Missense_Mutation_p.E285Q|SMEK2_uc002rza.2_Missense_Mutation_p.E161Q	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	285						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGAAAATTCTCTTCAAAAACA	0.348													0	0	0	0.01441	0	61	37										G	55825620	C	G	55825620	3	3	42	1	0	0	0	0	1	0	0	0	14794	922	32	1	1752	1	SMEK2	2	55825620	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	349042	55825620	187373753	41	10781										
GPAT2	150763	broad.mit.edu	37	chr2	96688908	96688908	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggcagcctgtgcaaaggcctTgagcagcgggctgagcaggc	17	11	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:96688908T>G	uc002svf.2	-	19	2318	c.2095A>C	c.(2095-2097)AAG>CAG	p.K699Q	GPAT2_uc002svd.2_Missense_Mutation_p.K518Q|GPAT2_uc002sve.2_Missense_Mutation_p.K501Q|GPAT2_uc002svg.2_Missense_Mutation_p.K578Q|GPAT2_uc010yuh.1_Missense_Mutation_p.K628Q|GPAT2_uc002svh.2_Intron	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	699					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GCAAAGGCCTTGAGCAGCGGG	0.642													0	0	0	0.001855	0	12	53										G	96688908	T	G	96688908	3	3	42	1	0	0	0	0	1	0	0	0	6589	1821	63	5	308	5	GPAT2	2	96688908	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	40863288	96688908	146510465	42	10782										
SLC9A4	389015	broad.mit.edu	37	chr2	103090411	103090411	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgtttttgaactggattatGactatgtgcaaattccttat	7	6	0	2	rs141209381		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:103090411G>A	uc002tbz.3	+	1	650	c.193G>A	c.(193-195)GAC>AAC	p.D65N		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	65	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						ACTGGATTATGACTATGTGCA	0.423													0	0	0	0.005443	0	28	216										A	103090411	G	A	103090411	3	1	42	1	0	0	0	0	1	0	0	0	14716	1290	45	1	195	1	SLC9A4	2	103090411	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	6401503	103090411	140108962	43	10783										
SULT1C2	6819	broad.mit.edu	37	chr2	108910720	108910720	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aggaaattgtggatatgattGaacagaatggggacgtggag	16	2	0	3	rs144954759		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:108910720G>C	uc002tdy.2	+	3	640	c.187G>C	c.(187-189)GAA>CAA	p.E63Q	SULT1C2_uc010ywp.1_5'UTR|SULT1C2_uc002tdx.2_Missense_Mutation_p.E63Q|SULT1C2_uc010ywq.1_Missense_Mutation_p.E63Q	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	63					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						GGATATGATTGAACAGAATGG	0.517													0	0	0	0.01441	0	127	76										C	108910720	G	C	108910720	3	2	42	1	0	0	0	0	1	0	0	0	15374	1291	45	1	193	1	SULT1C2	2	108910720	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	5820309	108910720	134288653	44	10784										
GCC2	9648	broad.mit.edu	37	chr2	109088444	109088444	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcaagttgaagaagtatctCaaacatgtagcaaaagtgaa	8	5	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:109088444C>G	uc002tec.2	+	6	2813	c.2659C>G	c.(2659-2661)CAA>GAA	p.Q887E	GCC2_uc002ted.2_Missense_Mutation_p.Q786E	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	887	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AGAAGTATCTCAAACATGTAG	0.308													0	0	0	0.01441	0	52	38										G	109088444	C	G	109088444	3	3	42	1	0	0	0	0	1	0	0	0	6286	827	29	1	2681	1	GCC2	2	109088444	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	177724	109088444	134110929	45	10785										
SCTR	6344	broad.mit.edu	37	chr2	120204401	120204401	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcgtcctctggggagaaggcGaagacgatgtagtggatgcc	17	8	1	2	rs140245245		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:120204401G>A	uc002tma.2	-	11	1300	c.1074C>T	c.(1072-1074)TTC>TTT	p.F358F	SCTR_uc002tlz.2_Silent_p.F180F	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	358	Helical; Name=6; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	GGGAGAAGGCGAAGACGATGT	0.572													0	0	0	0.004878	0	30	139										A	120204401	G	A	120204401	2	1	42	1	0	0	0	0	0	0	0	1	13943	1049	37	1		1	SCTR	2	120204401	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11115957	120204401	122994972	46	10786										
CLASP1	23332	broad.mit.edu	37	chr2	122098465	122098465	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcgtggagacatcggaggagGagctgctgttgctgttggtg	19	6	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:122098465G>A	uc002tnc.2	-	39	4979	c.4589C>T	c.(4588-4590)TCC>TTC	p.S1530F	CLASP1_uc010yyv.1_Missense_Mutation_p.S576F|CLASP1_uc002tmz.2_Missense_Mutation_p.S615F|CLASP1_uc002tna.2_Missense_Mutation_p.S576F|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.S1471F|CLASP1_uc010yza.1_Missense_Mutation_p.S1463F|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tmy.2_Missense_Mutation_p.S366F	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1530	Localization to kinetochores.|Interaction with PHLDB2 and RSN.|Poly-Ser.|Interaction with CLIP2 (By similarity).				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					ATCGGAGGAGGAGCTGCTGTT	0.488													0	0	0	0.001855	0	13	25										A	122098465	G	A	122098465	3	1	42	1	0	0	0	0	1	0	0	0	3454	1174	41	1	31	1	CLASP1	2	122098465	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1894064	122098465	121100908	47	10787										
GRB14	2888	broad.mit.edu	37	chr2	165365357	165365357	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgaaaaactgcaaatgccgCggttccttaaaaaaaaaagt	7	8	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:165365357C>T	uc002ucl.2	-	7	1363	c.822G>A	c.(820-822)CCG>CCA	p.P274P	GRB14_uc010zcv.1_Silent_p.P187P|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	274	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GCAAATGCCGCGGTTCCTTAA	0.328													0	0	0	0.010504	0	20	99										T	165365357	C	T	165365357	2	4	42	1	0	0	0	0	0	0	0	1	6757	755	27	2		2	GRB14	2	165365357	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	43266892	165365357	77834016	48	10788										
XIRP2	129446	broad.mit.edu	37	chr2	168103464	168103464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcagccaggctgtaaatcaGaaaacagtgacgaaaacaga	9	9	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:168103464G>A	uc002udx.2	+	8	5580	c.5562G>A	c.(5560-5562)CAG>CAA	p.Q1854Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.Q1679Q|XIRP2_uc010fpq.2_Silent_p.Q1632Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1679					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTGTAAATCAGAAAACAGTGA	0.388													0	0	0	0.007291	0	28	40										A	168103464	G	A	168103464	2	1	42	1	0	0	0	0	0	0	0	1	17427	933	33	1		1	XIRP2	2	168103464	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2738107	168103464	75095909	49	10789										
TTN	7273	broad.mit.edu	37	chr2	179433265	179433265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgtgattccatattgtccaCcatcatccttatgagtttct	5	11	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:179433265C>T	uc010zfg.1	-	275	70114	c.69890G>A	c.(69889-69891)GGT>GAT	p.G23297D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16992D|TTN_uc010zfi.1_Missense_Mutation_p.G16925D|TTN_uc010zfj.1_Missense_Mutation_p.G16800D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24224							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTGTCCACCATCATCCTT	0.413													0	0	0	0.00499	0	17	56										T	179433265	C	T	179433265	3	4	42	1	0	0	0	0	1	0	0	0	16732	507	18	2	30533	2	TTN	2	179433265	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	11329801	179433265	63766108	50	10790										
TTN	7273	broad.mit.edu	37	chr2	179445285	179445285	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtctcatagtaactccagcaCgtaatatgagtgtcttcctt	7	10	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:179445285C>T	uc010zfg.1	-	266	59341	c.59117G>A	c.(59116-59118)CGT>CAT	p.R19706H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R13401H|TTN_uc010zfi.1_Missense_Mutation_p.R13334H|TTN_uc010zfj.1_Missense_Mutation_p.R13209H|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20633							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTCCAGCACGTAATATGAG	0.378													0	0	0	0.001984	0	6	25										T	179445285	C	T	179445285	3	4	42	1	0	0	0	0	1	0	0	0	16732	536	19	2	41342	2	TTN	2	179445285	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	12020	179445285	63754088	51	10791										
TTN	7273	broad.mit.edu	37	chr2	179578722	179578722	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcggtgctacattgatgatcTtaaggccggatactttgttg	11	7	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:179578722T>C	uc010zfg.1	-	89	23155	c.22931A>G	c.(22930-22932)AAG>AGG	p.K7644R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K4305R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8571							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.K7644R(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGATGATCTTAAGGCCGGA	0.443													0	0	0	0.004482	0	9	26										C	179578722	T	C	179578722	3	2	42	1	0	0	0	0	1	0	0	0	16732	1609	56	5	77950	5	TTN	2	179578722	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	133437	179578722	63620651	52	10792										
ITGA4	3676	broad.mit.edu	37	chr2	182339776	182339776	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cactttccagacagccaggaGaaaatggatccatcgtggta	10	10	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:182339776G>A	uc002unu.2	+	3	1172	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ITGA4_uc010zfl.1_Missense_Mutation_p.E137K	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	137	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ACAGCCAGGAGAAAATGGATC	0.458													0	0	0	0.00308	0	6	26										A	182339776	G	A	182339776	3	1	42	1	0	0	0	0	1	0	0	0	7878	943	33	1	419	1	ITGA4	2	182339776	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2761054	182339776	60859597	53	10793										
CPS1	1373	broad.mit.edu	37	chr2	211473145	211473145	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atcccacttccagaaattaaGaacgtcgtatccgggaagac	8	11	0	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:211473145G>C	uc002vee.3	+	19	2385	c.2253G>C	c.(2251-2253)AAG>AAC	p.K751N	CPS1_uc010fur.2_Missense_Mutation_p.K757N|CPS1_uc010fus.2_Missense_Mutation_p.K300N	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	751					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CAGAAATTAAGAACGTCGTAT	0.423													0	0	0	0.005524	0	37	51										C	211473145	G	C	211473145	3	2	42	1	0	0	0	0	1	0	0	0	3823	933	33	1	2349	1	CPS1	2	211473145	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	29133369	211473145	31726228	54	10794										
SPEG	10290	broad.mit.edu	37	chr2	220353543	220353543	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccagaggtaccccagacctaCcaggacacggcgctggtgct	12	15	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:220353543C>T	uc010fwg.2	+	34	8070	c.8070C>T	c.(8068-8070)TAC>TAT	p.Y2690Y		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2690	Fibronectin type-III 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCAGACCTACCAGGACACGG	0.612													0	0	0	0.00245	0	14	24										T	220353543	C	T	220353543	2	4	42	1	0	0	0	0	0	0	0	1	15035	518	18	2		2	SPEG	2	220353543	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	8880398	220353543	22845830	55	10795										
CCDC140	151278	broad.mit.edu	37	chr2	223168711	223168711	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaccagaggcaagaggctgcGaatgagtccaacacccgcgt	12	12	0	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:223168711G>A	uc002vnb.1	+	2	474	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_153038	NP_694583	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	30											0		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGAGGCTGCGAATGAGTCCA	0.547													0	0	0	0.00874	0	41	66										A	223168711	G	A	223168711	2	1	42	1	0	0	0	0	0	0	0	1	2774	1045	37	1		1	CCDC140	2	223168711	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2815168	223168711	20030662	56	10796										
SEC13	6396	broad.mit.edu	37	chr3	10354378	10354378	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aggatgttgccgtacatgggGtgagcccaggccacttgcca	14	11	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:10354378G>A	uc003bvn.2	-	4	320	c.201C>T	c.(199-201)CAC>CAT	p.H67H	SEC13_uc003bvl.2_5'UTR|SEC13_uc003bvm.2_Silent_p.H53H|SEC13_uc003bvp.2_Silent_p.H70H|SEC13_uc003bvo.2_Silent_p.H113H|SEC13_uc003bvq.1_Silent_p.H53H|SEC13_uc003bvr.1_Silent_p.H53H|SEC13_uc011aul.1_Silent_p.H67H	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	67	WD 2.				COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						CGTACATGGGGTGAGCCCAGG	0.562													0	0	0	0.010818	0	28	180										A	10354378	G	A	10354378	2	1	42	1	0	0	0	0	0	0	0	1	13980	1252	44	2		2	SEC13	3	10354378	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		10354378	187668052	57	10797										
LAMB2	3913	broad.mit.edu	37	chr3	49169709	49169709	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acccatggcctcaccattctCtgactgccaccaggctgccc	7	19	2	1	rs1131783		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:49169709C>G	uc003cwe.2	-	3	678	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	LAMB2_uc003cwf.1_Missense_Mutation_p.E127Q	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	127	Laminin N-terminal.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCACCATTCTCTGACTGCCAC	0.602													0	0	0	0.01441	0	61	35										G	49169709	C	G	49169709	3	3	42	1	0	0	0	0	1	0	0	0	8611	922	32	1	5137	1	LAMB2	3	49169709	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	38815331	49169709	148852721	58	10798										
CCDC71	64925	broad.mit.edu	37	chr3	49201104	49201104	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttaagtggaaccagggcctCaaggacaacagagagccgca	12	11	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:49201104C>G	uc003cwg.3	-	2	676	c.538G>C	c.(538-540)GAG>CAG	p.E180Q		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	180										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACCAGGGCCTCAAGGACAACA	0.587													0	0	0	0.01441	0	118	58										G	49201104	C	G	49201104	3	3	42	1	0	0	0	0	1	0	0	0	2844	835	29	1	869	1	CCDC71	3	49201104	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	31395	49201104	148821326	59	10799										
ZPLD1	131368	broad.mit.edu	37	chr3	102195877	102195877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgagactccaaccaacaattCgcaacttggtaagataatta	6	9	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:102195877C>T	uc003dvs.1	+	17	1946	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L	ZPLD1_uc003dvt.1_Missense_Mutation_p.S371L|ZPLD1_uc011bhg.1_Missense_Mutation_p.S355L	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	355	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						ACCAACAATTCGCAACTTGGT	0.308													0	0	0	0.013114	0	41	93										T	102195877	C	T	102195877	3	4	42	1	0	0	0	0	1	0	0	0	18218	893	31	1	1150	1	ZPLD1	3	102195877	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	52994773	102195877	95826553	60	10800										
PLCXD2	257068	broad.mit.edu	37	chr3	111394145	111394145	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caggatggggaccatctgctCccccaaccccagcgggacaa	11	16	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:111394145C>A	uc003dya.2	+	1	639	c.53C>A	c.(52-54)TCC>TAC	p.S18Y	PLCXD2_uc003dyb.2_Missense_Mutation_p.S18Y|PLCXD2_uc003dxz.2_Missense_Mutation_p.S18Y	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	18					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						ACCATCTGCTCCCCCAACCCC	0.582													1	0	3.90053e-15	0.012213	4.1273e-15	30	179										A	111394145	C	A	111394145	3	1	42	1	0	0	0	0	1	0	0	0	12042	855	30	3	55	3	PLCXD2	3	111394145	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	9198268	111394145	86628285	61	10801										
KIAA2018	205717	broad.mit.edu	37	chr3	113379606	113379606	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcactttagtggcagttgctGaggagctgtgggggatgttt	17	5	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:113379606G>A	uc003eam.2	-	7	1334	c.923C>T	c.(922-924)TCA>TTA	p.S308L	KIAA2018_uc003eal.2_Missense_Mutation_p.S252L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	308					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GGCAGTTGCTGAGGAGCTGTG	0.413													0	0	0	0.01441	0	50	77										A	113379606	G	A	113379606	3	1	42	1	0	0	0	0	1	0	0	0	8268	1294	45	1	5818	1	KIAA2018	3	113379606	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1985461	113379606	84642824	62	10802										
KTELC1	56983	broad.mit.edu	37	chr3	119209463	119209463	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acacctcttcctgtgtggctCacttgttttccatgttggtg	9	11	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:119209463C>A	uc003ecm.2	+	9	947	c.863C>A	c.(862-864)TCA>TAA	p.S288*	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Nonsense_Mutation_p.S129*	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	288						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		CTGTGTGGCTCACTTGTTTTC	0.413													1	0	3.76114e-14	0.004289	3.97057e-14	37	215										A	119209463	C	A	119209463	4	1	42	1	0	0	0	0	0	1	0	0	8583	838	29	3	897	3	KTELC1	3	119209463	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	5829857	119209463	78812967	63	10803										
EEFSEC	60678	broad.mit.edu	37	chr3	128126998	128126998	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtggggaggccaccaggcagGaggagagcgccgagcggagc	21	10	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:128126998G>A	uc003eki.2	+	7	1725	c.1687G>A	c.(1687-1689)GAG>AAG	p.E563K	EEFSEC_uc003ekj.2_3'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	563						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						CACCAGGCAGGAGGAGAGCGC	0.642													0	0	0	0.01441	0	101	123										A	128126998	G	A	128126998	3	1	42	1	0	0	0	0	1	0	0	0	4931	1175	41	1	1713	1	EEFSEC	3	128126998	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	8917535	128126998	69895432	64	10804										
PCOLCE2	26577	broad.mit.edu	37	chr3	142539827	142539827	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctttgtagatgttgatgatcGagactgtggcgtgcaaactc	12	7	0	4	rs2304735		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:142539827G>C	uc003evd.2	-	8	1206	c.1010C>G	c.(1009-1011)TCG>TGG	p.S337W		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	337	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GTTGATGATCGAGACTGTGGC	0.502													0	0	0	0.008361	0	29	48										C	142539827	G	C	142539827	3	2	42	1	0	0	0	0	1	0	0	0	11595	1059	37	1	245	1	PCOLCE2	3	142539827	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	14412829	142539827	55482603	65	10805										
ZIC1	7545	broad.mit.edu	37	chr3	147130454	147130454	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acacgcatcccagttcgctgCgcaaacacatgaaggtaatc	8	13	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:147130454C>T	uc003ewe.2	+	2	1851	c.1132C>T	c.(1132-1134)CGC>TGC	p.R378C		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	378	C2H2-type 5.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAGTTCGCTGCGCAAACACAT	0.597													0	0	0	0.01441	0	61	396										T	147130454	C	T	147130454	3	4	42	1	0	0	0	0	1	0	0	0	17675	768	27	2	1138	2	ZIC1	3	147130454	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4590627	147130454	50891976	66	10806										
SLC33A1	9197	broad.mit.edu	37	chr3	155546144	155546144	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	catccagggctgtaacacatGagccacccagttttttgcaa	8	12	0	1	rs149578822		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:155546144G>A	uc003fan.3	-	6	1886	c.1505C>T	c.(1504-1506)TCA>TTA	p.S502L	SLC33A1_uc003fao.1_Missense_Mutation_p.S502L	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	502	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGTAACACATGAGCCACCCAG	0.313													0	0	0	0.01441	0	51	55										A	155546144	G	A	155546144	3	1	42	1	0	0	0	0	1	0	0	0	14566	1294	45	1	148	1	SLC33A1	3	155546144	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	8415690	155546144	42476286	67	10807										
PIK3CA	5290	broad.mit.edu	37	chr3	178928079	178928079	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggccagtacctcatggattaGaagatttgctgaaccctatt	9	9	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:178928079G>C	uc003fjk.2	+	8	1514	c.1357G>C	c.(1357-1359)GAA>CAA	p.E453Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(5)|p.E453Q(1)|p.E453A(1)|p.P449_L455del(1)|p.G451_L456>V(1)|p.E453del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATGGATTAGAAGATTTGCT	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.01441	0	82	74										C	178928079	G	C	178928079	3	2	42	1	0	0	0	0	1	0	0	0	11913	943	33	1	1383	1	PIK3CA	3	178928079	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	23381935	178928079	19094351	68	10808										
MCCC1	56922	broad.mit.edu	37	chr3	182759419	182759419	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggagtagagaggtgcactaaTgggcctgccacaggcatgaa	15	8	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:182759419T>C	uc003fle.2	-	11	1340	c.1203A>G	c.(1201-1203)CCA>CCG	p.P401P	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.P284P|MCCC1_uc003flg.2_Silent_p.P292P|MCCC1_uc011bqp.1_Silent_p.P354P	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	401	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GGTGCACTAATGGGCCTGCCA	0.458													0	0	0	0.01441	0	71	99										C	182759419	T	C	182759419	2	2	42	1	0	0	0	0	0	0	0	1	9374	1451	51	5		5	MCCC1	3	182759419	Silent	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	3831340	182759419	15263011	69	10809										
EIF4G1	1981	broad.mit.edu	37	chr3	184041700	184041700	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gggtcattgacctcatttttGagaaggccatttcagagccc	10	10	3	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:184041700G>C	uc003fnp.2	+	16	2605	c.2407G>C	c.(2407-2409)GAG>CAG	p.E803Q	EIF4G1_uc003fno.1_Missense_Mutation_p.E744Q|EIF4G1_uc010hxw.1_Missense_Mutation_p.E639Q|EIF4G1_uc003fnt.2_Missense_Mutation_p.E514Q|EIF4G1_uc003fnq.2_Missense_Mutation_p.E716Q|EIF4G1_uc003fnr.2_Missense_Mutation_p.E639Q|EIF4G1_uc010hxx.2_Missense_Mutation_p.E810Q|EIF4G1_uc003fns.2_Missense_Mutation_p.E763Q|EIF4G1_uc010hxy.2_Missense_Mutation_p.E810Q|EIF4G1_uc003fnv.3_Missense_Mutation_p.E804Q|EIF4G1_uc003fnu.3_Missense_Mutation_p.E803Q|EIF4G1_uc003fnw.2_Missense_Mutation_p.E810Q|EIF4G1_uc003fnx.2_Missense_Mutation_p.E608Q|EIF4G1_uc003fny.3_Missense_Mutation_p.E607Q|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	803	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCTCATTTTTGAGAAGGCCAT	0.517													0	0	0	0.01441	0	117	297										C	184041700	G	C	184041700	3	2	42	1	0	0	0	0	1	0	0	0	5036	1291	45	1	2461	1	EIF4G1	3	184041700	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1282281	184041700	13980730	70	10810										
EPHB3	2049	broad.mit.edu	37	chr3	184299313	184299313	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cacctgcagagacctgctccGtattggggtcaccctggccg	12	15	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:184299313G>T	uc003foz.2	+	16	3337	c.2900G>T	c.(2899-2901)CGT>CTT	p.R967L		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	967	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GACCTGCTCCGTATTGGGGTC	0.607													1	0	2.44813e-32	0.01441	2.63334e-32	58	72										T	184299313	G	T	184299313	3	4	42	1	0	0	0	0	1	0	0	0	5176	1145	40	4	2962	4	EPHB3	3	184299313	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	257613	184299313	13723117	71	10811										
MAP3K13	9175	broad.mit.edu	37	chr3	185146688	185146688	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggaacagcaacacggtggacGgagagagcacaagcggaact	15	9	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:185146688G>A	uc010hyf.2	+	3	585	c.319G>A	c.(319-321)GGA>AGA	p.G107R	MAP3K13_uc011brt.1_Intron|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Intron|MAP3K13_uc003fpi.2_Missense_Mutation_p.G107R|MAP3K13_uc010hyg.2_5'UTR	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	107					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			CACGGTGGACGGAGAGAGCAC	0.517													0	0	0	0.014323	0	22	60										A	185146688	G	A	185146688	3	1	42	1	0	0	0	0	1	0	0	0	9247	1117	39	2	321	2	MAP3K13	3	185146688	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	847375	185146688	12875742	72	10812										
TNK2	10188	broad.mit.edu	37	chr3	195599180	195599181	+	Frame_Shift_Ins	INS	-	-	G													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgggaagccccagcagtggcINSgggggtcactgtcgccatgc							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:195599180_195599181insG	uc003fvu.1	-	10	1960_1961	c.1417_1418insC	c.(1417-1419)CGCfs	p.R473fs	TNK2_uc003fvq.1_5'Flank|TNK2_uc003fvr.1_5'UTR|TNK2_uc003fvs.1_Frame_Shift_Ins_p.R505fs|TNK2_uc003fvt.1_Frame_Shift_Ins_p.R536fs|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Frame_Shift_Ins_p.R303fs	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	473				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CCAGCAGTGGCGGGGGTCACTG	0.673																		19	288	---	---								G	195599181	-	G	195599180	7	5	42	1	0	1	1	0	0	0	0	0	16315	768	27	0	1771	0	TNK2	3	195599180	Frame_Shift_Ins	INS	-	TCGA-DK-A1A6-01A-11D-A13W-08	10452492	195599180	2423250	73	10813										
ZNF721	170960	broad.mit.edu	37	chr4	437033	437033	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctctctggtgtgaattctcTtatgtgcagtaaggtttgtt	10	6	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:437033T>G	uc003gag.2	-	3	1914	c.1223A>C	c.(1222-1224)AAG>ACG	p.K408T	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.K440T|ZNF721_uc010ibe.2_Missense_Mutation_p.K396T	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	408						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GTGAATTCTCTTATGTGCAGT	0.393													0	0	0	0.013726	0	34	46										G	437033	T	G	437033	3	3	42	1	0	0	0	0	1	0	0	0	18119	1609	56	5	1552	5	ZNF721	4	437033	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08		437033	190717243	74	10814										
MXD4	10608	broad.mit.edu	37	chr4	2252408	2252408	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagctcaccagggccaaactCcatgccctctatgtccactt	6	17	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:2252408C>G	uc003geu.1	-	6	525	c.493G>C	c.(493-495)GAG>CAG	p.E165Q		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	165					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						GGGCCAAACTCCATGCCCTCT	0.607													0	0	0	0.01441	0	47	96										G	2252408	C	G	2252408	3	3	42	1	0	0	0	0	1	0	0	0	10001	864	30	1	140	1	MXD4	4	2252408	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1815375	2252408	188901868	75	10815										
MXD4	10608	broad.mit.edu	37	chr4	2252892	2252892	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gctctgcaccgacagctgctCcaggcgccgcttcaggaaac	11	16	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:2252892C>G	uc003geu.1	-	5	423	c.391G>C	c.(391-393)GAG>CAG	p.E131Q		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	131					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						GACAGCTGCTCCAGGCGCCGC	0.677													0	0	0	0.015359	0	26	45										G	2252892	C	G	2252892	3	3	42	1	0	0	0	0	1	0	0	0	10001	864	30	1	246	1	MXD4	4	2252892	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	484	2252892	188901384	76	10816										
HTRA3	94031	broad.mit.edu	37	chr4	8284261	8284261	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtccacatagagctcttcctGaggtgggtgaatacccctcg	11	12	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:8284261G>A	uc003gla.2	+	2	687	c.483G>A	c.(481-483)CTG>CTA	p.L161L	HTRA3_uc003gkz.2_Silent_p.L161L	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	161					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						AGCTCTTCCTGAGGTGGGTGA	0.617													0	0	0	0.006999	0	38	44										A	8284261	G	A	8284261	2	1	42	1	0	0	0	0	0	0	0	1	7455	1277	45	1		1	HTRA3	4	8284261	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	6031369	8284261	182870015	77	10817										
ZCCHC4	29063	broad.mit.edu	37	chr4	25351119	25351119	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttttatttgttccagactgcCcttgaagtatgcagagcatt	8	8	0	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:25351119C>T	uc003grl.3	+	7	801	c.765C>T	c.(763-765)GCC>GCT	p.A255A	ZCCHC4_uc003grm.1_RNA|ZCCHC4_uc003grn.3_Silent_p.A21A	NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	255							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				TCCAGACTGCCCTTGAAGTAT	0.408													0	0	0	0.01441	0	54	101										T	25351119	C	T	25351119	2	4	42	1	0	0	0	0	0	0	0	1	17587	610	22	2		2	ZCCHC4	4	25351119	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	17066858	25351119	165803157	78	10818										
SHISA3	152573	broad.mit.edu	37	chr4	42403228	42403228	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	accagccccagggcaccctcCcggcagtccagcacagccac	9	21	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:42403228C>T	uc003gwp.2	+	2	695	c.477C>T	c.(475-477)TCC>TCT	p.S159S		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	159	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						GGGCACCCTCCCGGCAGTCCA	0.672													0	0	0	0.01441	0	95	267										T	42403228	C	T	42403228	2	4	42	1	0	0	0	0	0	0	0	1	14281	610	22	2		2	SHISA3	4	42403228	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	17052109	42403228	148751048	79	10819										
GABRG1	2565	broad.mit.edu	37	chr4	46043250	46043250	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cattggaatcagagtggatcCaggatggagaccaggagtca	14	7	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:46043250C>A	uc003gxb.2	-	9	1305	c.1153G>T	c.(1153-1155)GGA>TGA	p.G385*		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	385	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AGAGTGGATCCAGGATGGAGA	0.388													1	0	7.16444e-05	0.003954	7.26018e-05	25	21										A	46043250	C	A	46043250	4	1	42	1	0	0	0	0	0	1	0	0	6171	603	21	4	248	4	GABRG1	4	46043250	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3640022	46043250	145111026	80	10820										
GABRB1	2560	broad.mit.edu	37	chr4	47427997	47427997	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttttccccatcaccttttctCtttttaatgtcgtctattgg	4	11	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:47427997C>T	uc003gxh.2	+	9	1761	c.1387C>T	c.(1387-1389)CTT>TTT	p.L463F	GABRB1_uc011bze.1_Missense_Mutation_p.L393F	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	463	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CACCTTTTCTCTTTTTAATGT	0.428													0	0	0	0.01441	0	70	89										T	47427997	C	T	47427997	3	4	42	1	0	0	0	0	1	0	0	0	6166	913	32	1	1421	1	GABRB1	4	47427997	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1384747	47427997	143726279	81	10821										
AGXT2L1	64850	broad.mit.edu	37	chr4	109677623	109677623	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctgaactgccgagccaggcGtaaggctaagtcgttggctt	13	10	1	1	rs112469981		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:109677623G>A	uc003hzc.2	-	4	542	c.361C>T	c.(361-363)CGC>TGC	p.R121C	AGXT2L1_uc010imc.2_Missense_Mutation_p.R115C|AGXT2L1_uc011cfm.1_Missense_Mutation_p.R81C|AGXT2L1_uc011cfn.1_Missense_Mutation_p.R48C|AGXT2L1_uc011cfo.1_Missense_Mutation_p.R63C	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	121					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CGAGCCAGGCGTAAGGCTAAG	0.403													0	0	0	0.008871	0	17	61										A	109677623	G	A	109677623	3	1	42	1	0	0	0	0	1	0	0	0	406	1145	40	2	1178	2	AGXT2L1	4	109677623	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	62249626	109677623	81476653	82	10822										
ALPK1	80216	broad.mit.edu	37	chr4	113352240	113352240	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcaagaaaagccacattgtCaaagagacacaggaatatct	7	9	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:113352240C>G	uc003iap.3	+	11	1816	c.1537C>G	c.(1537-1539)CAA>GAA	p.Q513E	ALPK1_uc003ian.3_Missense_Mutation_p.Q513E|ALPK1_uc011cfx.1_Missense_Mutation_p.Q435E|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.Q341E	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	513							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GCCACATTGTCAAAGAGACAC	0.408													0	0	0	0.008361	0	30	29										G	113352240	C	G	113352240	3	3	42	1	0	0	0	0	1	0	0	0	544	827	29	1	1571	1	ALPK1	4	113352240	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3674617	113352240	77802036	83	10823										
USP53	54532	broad.mit.edu	37	chr4	120181753	120181753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agtctgggactccgagcattCtgacttgaccgaagctgttg	12	10	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:120181753C>G	uc003ics.3	+	10	1833	c.767C>G	c.(766-768)TCT>TGT	p.S256C	USP53_uc003icr.3_Missense_Mutation_p.S256C|USP53_uc003icu.3_5'UTR	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	256					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						TCCGAGCATTCTGACTTGACC	0.378													0	0	0	0.01441	0	42	44										G	120181753	C	G	120181753	3	3	42	1	0	0	0	0	1	0	0	0	17081	913	32	1	793	1	USP53	4	120181753	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	6829513	120181753	70972523	84	10824										
PCDH10	57575	broad.mit.edu	37	chr4	134072435	134072435	+	Frame_Shift_Del	DEL	C	C	-													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggcactgtggtggcccttttCagcgtgactgaccgcgactc							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:134072435delC	uc003iha.2	+	1	1966	c.1140delC	c.(1138-1140)TTCfs	p.F380fs	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Frame_Shift_Del_p.F380fs	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	380	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGCCCTTTTCAGCGTGACTG	0.577																		202	192	---	---								-	134072435	C	-	134072435	7	5	42	1	0	1	0	1	0	0	0	0	11507	825	29	0	1142	0	PCDH10	4	134072435	Frame_Shift_Del	DEL	C	TCGA-DK-A1A6-01A-11D-A13W-08	13890682	134072435	57081841	85	10825										
OTUD4	54726	broad.mit.edu	37	chr4	146063358	146063358	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttctctaacctgttggtccAaaagttgtaggttcacttgg	9	9	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:146063358A>G	uc003ika.3	-	18	1755	c.1617T>C	c.(1615-1617)TTT>TTC	p.F539F	OTUD4_uc003ijz.3_Silent_p.F538F	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	603							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CTGTTGGTCCAAAAGTTGTAG	0.468													0	0	0	0.01441	0	53	170										G	146063358	A	G	146063358	2	3	42	1	0	0	0	0	0	0	0	1	11314	127	5	5		5	OTUD4	4	146063358	Silent	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	11990923	146063358	45090918	86	10826										
CCDC110	256309	broad.mit.edu	37	chr4	186380089	186380089	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccatatcactttgagttttgTgttccttactttttagttga	6	7	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:186380089T>C	uc003ixu.3	-	6	1728	c.1652A>G	c.(1651-1653)CAC>CGC	p.H551R	CCDC110_uc003ixv.3_Missense_Mutation_p.H514R|CCDC110_uc011ckt.1_Missense_Mutation_p.H551R	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	551	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTGAGTTTTGTGTTCCTTACT	0.303													0	0	0	0.003163	0	13	35										C	186380089	T	C	186380089	3	2	42	1	0	0	0	0	1	0	0	0	2747	1696	59	5	857	5	CCDC110	4	186380089	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	40316731	186380089	4774187	87	10827										
DNAH5	1767	broad.mit.edu	37	chr5	13913870	13913870	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acctggtatttagtggccatGtcttccagcccttcaattgt	8	11	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:13913870G>A	uc003jfd.2	-	11	1560	c.1518C>T	c.(1516-1518)GAC>GAT	p.D506D	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	506	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TAGTGGCCATGTCTTCCAGCC	0.358									Kartagener_syndrome				0	0	0	0.01441	0	45	35										A	13913870	G	A	13913870	2	1	42	1	0	0	0	0	0	0	0	1	4604	1368	48	2		2	DNAH5	5	13913870	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		13913870	167001390	88	10828										
FBXL7	23194	broad.mit.edu	37	chr5	15937113	15937113	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgaactgcttcaacctcaagCggctcagcctcaagtcctgc	8	15	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:15937113C>G	uc003jfn.1	+	4	1775	c.1294C>G	c.(1294-1296)CGG>GGG	p.R432G		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	432	LRR 10.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CAACCTCAAGCGGCTCAGCCT	0.582													0	0	0	0.012319	0	23	70										G	15937113	C	G	15937113	3	3	42	1	0	0	0	0	1	0	0	0	5724	759	27	4	1308	4	FBXL7	5	15937113	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2023243	15937113	164978147	89	10829										
PDZD2	23037	broad.mit.edu	37	chr5	32074145	32074145	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgatgaggaagagtttgacaGagaaggggactgcatttcac	14	5	1	5			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:32074145G>C	uc003jhl.2	+	18	3321	c.2933G>C	c.(2932-2934)AGA>ACA	p.R978T	PDZD2_uc003jhm.2_Missense_Mutation_p.R978T|PDZD2_uc011cnx.1_Missense_Mutation_p.R804T	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	978					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GAGTTTGACAGAGAAGGGGAC	0.607													0	0	0	0.009535	0	33	53										C	32074145	G	C	32074145	3	2	42	1	0	0	0	0	1	0	0	0	11701	942	33	1	2999	1	PDZD2	5	32074145	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	16137032	32074145	148841115	90	10830										
WDR41	55255	broad.mit.edu	37	chr5	76736658	76736658	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcttcatcacatgtgaaatGatgaatagaaatgtcatttg	7	6	4	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:76736658G>C	uc003kff.1	-	9	1149	c.862C>G	c.(862-864)CAT>GAT	p.H288D	WDR41_uc011csy.1_Missense_Mutation_p.H230D|WDR41_uc011csz.1_Missense_Mutation_p.H233D|WDR41_uc011cta.1_RNA|WDR41_uc011ctb.1_RNA	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	288											0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		CATGTGAAATGATGAATAGAA	0.343													0	0	0	0.007413	0	20	33										C	76736658	G	C	76736658	3	2	42	1	0	0	0	0	1	0	0	0	17291	1290	45	1	537	1	WDR41	5	76736658	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	44662513	76736658	104178602	91	10831										
BRD8	10902	broad.mit.edu	37	chr5	137488324	137488324	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctggatcctcagtttccctCcagttgcccacatcaagatc	6	15	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:137488324C>G	uc003lcf.1	-	21	2758	c.2703G>C	c.(2701-2703)TGG>TGC	p.W901C	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	901					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGTTTCCCTCCAGTTGCCCA	0.517													0	0	0	0.01441	0	111	148										G	137488324	C	G	137488324	3	3	42	1	0	0	0	0	1	0	0	0	1506	856	30	1	1032	1	BRD8	5	137488324	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	60751666	137488324	43426936	92	10832										
TMCO6	55374	broad.mit.edu	37	chr5	140024595	140024595	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcaggtcttcctgcagcagtCagggctgcaagccctggaaa	12	12	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:140024595C>G	uc003lgl.2	+	12	1495	c.1394C>G	c.(1393-1395)TCA>TGA	p.S465*	TMCO6_uc003lgm.2_Nonsense_Mutation_p.S471*|TMCO6_uc010jft.2_Nonsense_Mutation_p.S225*|TMCO6_uc003lgn.2_Nonsense_Mutation_p.S356*|TMCO6_uc003lgo.2_Nonsense_Mutation_p.S225*|IK_uc011czk.1_5'Flank|IK_uc003lgq.2_5'Flank	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	465					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCAGCAGTCAGGGCTGCAA	0.537													0	0	0	0.01441	0	72	104										G	140024595	C	G	140024595	4	3	42	1	0	0	0	0	0	1	0	0	15997	838	29	1	1440	1	TMCO6	5	140024595	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2536271	140024595	40890665	93	10833										
PCDHGA3	56112	broad.mit.edu	37	chr5	140725379	140725379	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctggtgaccaaggtggtggcGgtggacagagactcgggcca	18	9	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:140725379G>A	uc003ljm.1	+	1	1779	c.1779G>A	c.(1777-1779)GCG>GCA	p.A593A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.A353A|PCDHGA3_uc011dap.1_Silent_p.A593A	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	593	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGGTGGCGGTGGACAGAG	0.692													0	0	0	0.01441	0	108	254										A	140725379	G	A	140725379	2	1	42	1	0	0	0	0	0	0	0	1	11555	1103	39	2		2	PCDHGA3	5	140725379	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	700784	140725379	40189881	94	10834										
PCDH1	5097	broad.mit.edu	37	chr5	141233792	141233792	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggccgttttggtgttccggtCttccggggggctggggctgc	19	10	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:141233792C>G	uc003llp.2	-	5	3646	c.3529G>C	c.(3529-3531)GAC>CAC	p.D1177H		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTGTTCCGGTCTTCCGGGGGG	0.667													0	0	0	0.004878	0	33	31										G	141233792	C	G	141233792	3	3	42	1	0	0	0	0	1	0	0	0	11506	913	32	1	188	1	PCDH1	5	141233792	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	508413	141233792	39681468	95	10835										
PCDH1	5097	broad.mit.edu	37	chr5	141233828	141233828	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gctgccggcgcccgcaggctCctgccctcctcggtcctggt	13	19	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:141233828C>G	uc003llp.2	-	5	3610	c.3493G>C	c.(3493-3495)GAG>CAG	p.E1165Q		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CCCGCAGGCTCCTGCCCTCCT	0.677													0	0	0	0.003755	0	28	27										G	141233828	C	G	141233828	3	3	42	1	0	0	0	0	1	0	0	0	11506	864	30	1	224	1	PCDH1	5	141233828	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	36	141233828	39681432	96	10836										
ADAM19	8728	broad.mit.edu	37	chr5	156946911	156946911	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agtccctggtggtgggcttgGagtgctcgaacccacagttt	14	10	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:156946911G>C	uc003lwz.2	-	6	600	c.536C>G	c.(535-537)TCC>TGC	p.S179C	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Missense_Mutation_p.S110C	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	179					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGGGCTTGGAGTGCTCGAA	0.552													0	0	0	0.009718	0	41	150										C	156946911	G	C	156946911	3	2	42	1	0	0	0	0	1	0	0	0	240	1174	41	1	2292	1	ADAM19	5	156946911	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	15713083	156946911	23968349	97	10837										
DOCK2	1794	broad.mit.edu	37	chr5	169507184	169507184	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagctttccaggaagcatgaGttcatgagtgacaccaacct	9	11	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:169507184G>A	uc003maf.2	+	50	5264	c.5184G>A	c.(5182-5184)GAG>GAA	p.E1728E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.E1220E|DOCK2_uc003mah.2_Silent_p.E284E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1728					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAAGCATGAGTTCATGAGTG	0.532													0	0	0	0.00499	0	17	92										A	169507184	G	A	169507184	2	1	42	1	0	0	0	0	0	0	0	1	4687	1020	36	2		2	DOCK2	5	169507184	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	12560273	169507184	11408076	98	10838										
RANBP17	64901	broad.mit.edu	37	chr5	170667947	170667947	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aacaggtaatcagatcctgtCccttgggagcctctcaaaag	9	11	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:170667947C>A	uc003mba.2	+	23	2454	c.2438C>A	c.(2437-2439)TCC>TAC	p.S813Y	RANBP17_uc003mbb.2_Missense_Mutation_p.S138Y|RANBP17_uc003mbd.2_Missense_Mutation_p.S176Y|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	813					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGATCCTGTCCCTTGGGAGC	0.383			T	TRD@	ALL								1	0	2.46105e-21	0.010818	2.61631e-21	30	81										A	170667947	C	A	170667947	3	1	42	1	0	0	0	0	1	0	0	0	13027	855	30	3	2528	3	RANBP17	5	170667947	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1160763	170667947	10247313	99	10839										
MAPK9	5601	broad.mit.edu	37	chr5	179666936	179666936	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atctttacctttccattcttCaattgcatgttctctttctt	2	11	5	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:179666936C>A	uc003mls.3	-	10	1319	c.1048G>T	c.(1048-1050)GAA>TAA	p.E350*	MAPK9_uc003mlt.3_Nonsense_Mutation_p.E350*|MAPK9_uc010jlc.2_Nonsense_Mutation_p.E350*|MAPK9_uc003mlv.3_Nonsense_Mutation_p.E350*	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	350					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCATTCTTCAATTGCATGT	0.348													1	0	1.2644e-06	0.010504	1.29573e-06	20	58										A	179666936	C	A	179666936	4	1	42	1	0	0	0	0	0	1	0	0	9287	835	29	3	243	3	MAPK9	5	179666936	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	8998989	179666936	1248324	100	10840										
TFAP2A	7020	broad.mit.edu	37	chr6	10410427	10410427	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgactgggggtagataggctGgtagggtggggggaagtatg	22	3	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:10410427G>A	uc003myr.2	-	2	439	c.187C>T	c.(187-189)CAG>TAG	p.Q63*	TFAP2A_uc003myq.2_Nonsense_Mutation_p.Q57*|TFAP2A_uc003mys.2_Intron|TFAP2A_uc011dih.1_Nonsense_Mutation_p.Q63*|TFAP2A_uc003myt.2_Nonsense_Mutation_p.Q59*|TFAP2A_uc003myu.1_Nonsense_Mutation_p.Q63*|TFAP2A_uc003myv.1_Nonsense_Mutation_p.Q49*|TFAP2A_uc011dii.1_Nonsense_Mutation_p.Q59*|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	63	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TAGATAGGCTGGTAGGGTGGG	0.657													0	0	0	0.01441	0	82	136										A	10410427	G	A	10410427	4	1	42	1	0	0	0	0	0	1	0	0	15784	1357	47	2	1150	2	TFAP2A	6	10410427	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		10410427	160704640	101	10841										
HIST1H1A	3024	broad.mit.edu	37	chr6	26017448	26017448	+	Frame_Shift_Del	DEL	T	T	-													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttgggctttacagttttgggTttttttggattcttggagga							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:26017448delT	uc003nfo.2	-	1	593	c.513delA	c.(511-513)AAAfs	p.K171fs		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	171					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						CAGTTTTGGGTTTTTTTGGAT	0.483																		7	1492	---	---								-	26017448	T	-	26017448	7	5	42	1	0	1	0	1	0	0	0	0	7122	1722	60	0	138	0	HIST1H1A	6	26017448	Frame_Shift_Del	DEL	T	TCGA-DK-A1A6-01A-11D-A13W-08	15607021	26017448	145097619	102	10842										
TRIM27	5987	broad.mit.edu	37	chr6	28891284	28891284	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtctctgccgtgccccagcaGcgggcgaggcacgcgcaaca	14	16	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:28891284G>A	uc003nlr.2	-	1	485	c.126C>T	c.(124-126)CGC>CGT	p.R42R	TRIM27_uc003nls.2_Silent_p.R42R|TRIM27_uc003nlt.1_Silent_p.R42R	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	42	RING-type.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TGCCCCAGCAGCGGGCGAGGC	0.672			T	RET	papillary thyroid								0	0	0	0.006214	0	10	42										A	28891284	G	A	28891284	2	1	42	1	0	0	0	0	0	0	0	1	16498	958	34	2		2	TRIM27	6	28891284	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2873836	28891284	142223783	103	10843										
OR10C1	442194	broad.mit.edu	37	chr6	29408455	29408455	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggctcctacgggcgtatcctCgttaccatcttccggatccc	9	16	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:29408455C>A	uc011dlp.1	+	1	663	c.663C>A	c.(661-663)CTC>CTA	p.L221L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCGTATCCTCGTTACCATCT	0.592													1	0	1.43987e-31	0.01441	1.54514e-31	70	265										A	29408455	C	A	29408455	2	1	42	1	0	0	0	0	0	0	0	1	10898	871	31	3		3	OR10C1	6	29408455	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	517171	29408455	141706612	104	10844										
HLA-DRA	3122	broad.mit.edu	37	chr6	32407746	32407746	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaatggccataagtggagtcCctgtgctaggatttttcatc	10	8	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:32407746C>T	uc003obh.2	+	1	100	c.19C>T	c.(19-21)CCT>TCT	p.P7S	HLA-DRA_uc003obi.2_Missense_Mutation_p.P7S	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	7					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						AAGTGGAGTCCCTGTGCTAGG	0.473									T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of				0	0	0	0.008871	0	17	26										T	32407746	C	T	32407746	3	4	42	1	0	0	0	0	1	0	0	0	7207	623	22	2	21	2	HLA-DRA	6	32407746	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2999291	32407746	138707321	105	10845										
PFDN6	10471	broad.mit.edu	37	chr6	33257970	33257970	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gacttaagtaaatccatgtcGgggaggcagaaacttgaagc	12	7	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:33257970G>A	uc003odt.1	+	3	199	c.84G>A	c.(82-84)TCG>TCA	p.S28S	WDR46_uc003ods.2_5'Flank|WDR46_uc011dra.1_5'Flank|WDR46_uc010juo.1_5'Flank|PFDN6_uc010jup.1_Silent_p.S28S	NM_014260	NP_055075	O15212	PFD6_HUMAN	HLA class II region expressed gene KE2	28					'de novo' posttranslational protein folding|chaperone-mediated protein complex assembly	prefoldin complex	chaperone binding|unfolded protein binding				0						AATCCATGTCGGGGAGGCAGA	0.468													0	0	0	0.00245	0	14	67										A	33257970	G	A	33257970	2	1	42	1	0	0	0	0	0	0	0	1	11759	1103	39	2		2	PFDN6	6	33257970	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	850224	33257970	137857097	106	10846										
ITPR3	3710	broad.mit.edu	37	chr6	33632979	33632979	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aacgagggcttcatcagccaGaatgaccgcaggtgggctgc	14	11	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:33632979G>C	uc011drk.1	+	13	1617	c.1398G>C	c.(1396-1398)CAG>CAC	p.Q466H		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	466	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCATCAGCCAGAATGACCGCA	0.567													0	0	0	0.01441	0	42	161										C	33632979	G	C	33632979	3	2	42	1	0	0	0	0	1	0	0	0	7922	933	33	1	1448	1	ITPR3	6	33632979	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	375009	33632979	137482088	107	10847										
HMGA1	3159	broad.mit.edu	37	chr6	34208621	34208621	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agcaggaaaaggacggcactGagaagcggggccggggcagg	20	8	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:34208621G>C	uc003oit.2	+	3	386	c.64G>C	c.(64-66)GAG>CAG	p.E22Q	HMGA1_uc011dso.1_Missense_Mutation_p.E22Q|HMGA1_uc003oiv.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiw.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiu.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiy.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiz.2_Missense_Mutation_p.E22Q|HMGA1_uc003oja.2_Missense_Mutation_p.E22Q|HMGA1_uc003oix.2_Missense_Mutation_p.E22Q|HMGA1_uc010jvl.2_RNA|HMGA1_uc003ojc.2_Missense_Mutation_p.E22Q|HMGA1_uc011dsp.1_RNA|HMGA1_uc003ojd.2_Missense_Mutation_p.E22Q	NM_145899	NP_665906	P17096	HMGA1_HUMAN	high mobility group AT-hook 1 isoform a	22	A.T hook 1.				DNA unwinding involved in replication|initiation of viral infection|interspecies interaction between organisms|loss of chromatin silencing|nucleosome disassembly|protein complex assembly|provirus integration	chromatin|cytosol|transcription factor complex	AT DNA binding|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|protein binding|retinoid X receptor binding|sequence-specific DNA binding transcription factor activity				0						GGACGGCACTGAGAAGCGGGG	0.622			T	NaN	microfollicular thyroid adenoma| various benign mesenchymal tumors,								0	0	0	0.01441	0	78	100										C	34208621	G	C	34208621	3	2	42	1	0	0	0	0	1	0	0	0	7223	1291	45	1	66	1	HMGA1	6	34208621	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	575642	34208621	136906446	108	10848										
FANCE	2178	broad.mit.edu	37	chr6	35423591	35423591	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgtccctgctgatggccgttCggccatcgctgccggaaagt	13	13	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:35423591C>T	uc003oko.1	+	2	501	c.316C>T	c.(316-318)CGG>TGG	p.R106W	FANCE_uc010jvw.1_Missense_Mutation_p.R106W	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	106					DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						GATGGCCGTTCGGCCATCGCT	0.607			N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.013114	0	43	121										T	35423591	C	T	35423591	3	4	42	1	0	0	0	0	1	0	0	0	5666	875	31	1	322	1	FANCE	6	35423591	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1214970	35423591	135691476	109	10849										
KHDRBS2	202559	broad.mit.edu	37	chr6	62688006	62688006	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tttaatctcttccaatgcatGactcatacgtgaataagctt	5	9	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:62688006G>A	uc003peg.2	-	4	695	c.448C>T	c.(448-450)CAT>TAT	p.H150Y		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding	p.H150Y(1)		skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCCAATGCATGACTCATACGT	0.373													0	0	0	0.014323	0	19	56										A	62688006	G	A	62688006	3	1	42	1	0	0	0	0	1	0	0	0	8147	1290	45	1	625	1	KHDRBS2	6	62688006	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	27264415	62688006	108427061	110	10850										
MTO1	25821	broad.mit.edu	37	chr6	74171644	74171644	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccaagcagcaatttccgttgGcacggttgagcagtgacagc	12	11	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:74171644G>T	uc003pgy.3	+	1	191	c.67G>T	c.(67-69)GCA>TCA	p.A23S	MTO1_uc010kav.2_Missense_Mutation_p.A23S|MTO1_uc003pgz.3_Missense_Mutation_p.A23S|MTO1_uc003pha.3_5'UTR|MTO1_uc003phb.3_Intron|MTO1_uc003phc.1_5'Flank	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	23					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						ATTTCCGTTGGCACGGTTGAG	0.592													1	0	1.7489e-18	0.011902	1.8549e-18	42	115										T	74171644	G	T	74171644	3	4	42	1	0	0	0	0	1	0	0	0	9953	1203	42	4	69	4	MTO1	6	74171644	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11483638	74171644	96943423	111	10851										
TAAR8	83551	broad.mit.edu	37	chr6	132874467	132874467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcatacctacccttgttatGataattctttacagtaagat	4	8	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:132874467G>C	uc011ecj.1	+	1	636	c.636G>C	c.(634-636)ATG>ATC	p.M212I		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	212	Helical; Name=5; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CCCTTGTTATGATAATTCTTT	0.328													0	0	0	0.004482	0	9	22										C	132874467	G	C	132874467	3	2	42	1	0	0	0	0	1	0	0	0	15490	1290	45	1	638	1	TAAR8	6	132874467	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	58702823	132874467	38240600	112	10852										
SASH1	23328	broad.mit.edu	37	chr6	148865205	148865205	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgccccctcagattgtacctGaagtgccacagaagacgacc	9	15	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:148865205G>C	uc003qme.1	+	18	3074	c.2599G>C	c.(2599-2601)GAA>CAA	p.E867Q	SASH1_uc011eeb.1_Missense_Mutation_p.E628Q|SASH1_uc003qmf.1_Missense_Mutation_p.E277Q	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	867							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GATTGTACCTGAAGTGCCACA	0.572													0	0	0	0.01441	0	196	111										C	148865205	G	C	148865205	3	2	42	1	0	0	0	0	1	0	0	0	13848	1291	45	1	2669	1	SASH1	6	148865205	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	15990738	148865205	22249862	113	10853										
ULBP1	80329	broad.mit.edu	37	chr6	150289814	150289814	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaccacagtggtgtgaagttCaaggcctggtggatgaaagg	15	6	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:150289814C>G	uc003qnp.2	+	2	200	c.157C>G	c.(157-159)CAA>GAA	p.Q53E		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	53	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		GTGTGAAGTTCAAGGCCTGGT	0.463													0	0	0	0.01441	0	145	73										G	150289814	C	G	150289814	3	3	42	1	0	0	0	0	1	0	0	0	16969	827	29	1	163	1	ULBP1	6	150289814	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1424609	150289814	20825253	114	10854										
SYNE1	23345	broad.mit.edu	37	chr6	152768727	152768727	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tttcagccagctgagggtctCaccccttttggtaacaccat	8	13	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:152768727C>T	uc010kiw.2	-	29	4137	c.3535G>A	c.(3535-3537)GAG>AAG	p.E1179K	SYNE1_uc003qot.3_Missense_Mutation_p.E1186K|SYNE1_uc003qou.3_Missense_Mutation_p.E1179K|SYNE1_uc010kjb.1_Missense_Mutation_p.E1162K|SYNE1_uc003qow.2_Missense_Mutation_p.E474K|SYNE1_uc003qox.1_Missense_Mutation_p.E695K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1179	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGAGGGTCTCACCCCTTTTG	0.423										HNSCC(10;0.0054)			0	0	0	0.01441	0	69	34										T	152768727	C	T	152768727	3	4	42	1	0	0	0	0	1	0	0	0	15442	835	29	1	23403	1	SYNE1	6	152768727	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2478913	152768727	18346340	115	10855										
MYCT1	80177	broad.mit.edu	37	chr6	153043097	153043097	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgtcgaagcaacctcagcctGgccagtctcaccttccagcg	9	17	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:153043097G>C	uc003qpd.3	+	2	425	c.417G>C	c.(415-417)CTG>CTC	p.L139L	MYCT1_uc010kjc.1_Intron|MYCT1_uc003qpc.3_Silent_p.L139L	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	139						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		ACCTCAGCCTGGCCAGTCTCA	0.493													0	0	0	0.01441	0	60	23										C	153043097	G	C	153043097	2	2	42	1	0	0	0	0	0	0	0	1	10022	1335	47	4		4	MYCT1	6	153043097	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	274370	153043097	18071970	116	10856										
PSMB1	5689	broad.mit.edu	37	chr6	170862293	170862293	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcggttccatccccaagtctCtgccaggagccgaatacatg	10	14	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:170862293C>T	uc011ehe.1	-	1	125	c.38G>A	c.(37-39)AGA>AAA	p.R13K	PSMB1_uc003qxq.2_RNA|PSMB1_uc003qxr.2_5'Flank|TBP_uc003qxt.2_5'Flank|TBP_uc003qxu.2_5'Flank|TBP_uc011ehf.1_5'Flank	NM_002793	NP_002784	P20618	PSB1_HUMAN	proteasome beta 1 subunit precursor	13					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	CCCCAAGTCTCTGCCAGGAGC	0.607													0	0	0	0.004007	0	14	5										T	170862293	C	T	170862293	3	4	42	1	0	0	0	0	1	0	0	0	12674	913	32	1	711	1	PSMB1	6	170862293	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	17819196	170862293	252774	117	10857										
SDK1	221935	broad.mit.edu	37	chr7	4051844	4051844	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccagaaacagagcacaacggGgtgttgcgtggatacatcct	12	10	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:4051844G>T	uc003smx.2	+	16	2536	c.2397G>T	c.(2395-2397)GGG>GGT	p.G799G	SDK1_uc010kso.2_Silent_p.G75G	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	799	Fibronectin type-III 2.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCACAACGGGGTGTTGCGTG	0.502													1	0	3.66986e-57	0.01441	4.01391e-57	89	90										T	4051844	G	T	4051844	2	4	42	1	0	0	0	0	0	0	0	1	13968	1219	43	4		4	SDK1	7	4051844	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		4051844	155086819	118	10858										
ACTB	60	broad.mit.edu	37	chr7	5568242	5568242	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gggcacagtgtgggtgacccCgtcaccggagtccatcacga	14	13	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:5568242C>T	uc003sos.3	-	3	508	c.472G>A	c.(472-474)GGG>AGG	p.G158R	ACTB_uc003sor.3_Missense_Mutation_p.G36R|ACTB_uc003sot.3_Missense_Mutation_p.G158R|ACTB_uc003soq.3_Missense_Mutation_p.G36R|ACTB_uc010ksy.2_Missense_Mutation_p.G36R	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	158					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGGGTGACCCCGTCACCGGAG	0.607													0	0	0	0.01441	0	84	264										T	5568242	C	T	5568242	3	4	42	1	0	0	0	0	1	0	0	0	193	652	23	2	667	2	ACTB	7	5568242	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1516398	5568242	153570421	119	10859										
SOSTDC1	25928	broad.mit.edu	37	chr7	16502559	16502559	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agagatgtatttggtggaacGcagttcccggcaacccactt	11	10	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:16502559G>A	uc003stg.2	-	2	416	c.235C>T	c.(235-237)CGT>TGT	p.R79C	SOSTDC1_uc003sth.2_Missense_Mutation_p.R103C	NM_015464	NP_056279	Q6X4U4	SOSD1_HUMAN	sclerostin domain containing 1 precursor	79	CTCK.				Wnt receptor signaling pathway					ovary(2)|central_nervous_system(1)	3	Lung NSC(10;0.185)			UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TTGGTGGAACGCAGTTCCCGG	0.502													0	0	0	0.006999	0	40	38										A	16502559	G	A	16502559	3	1	42	1	0	0	0	0	1	0	0	0	14939	1087	38	2	389	2	SOSTDC1	7	16502559	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10934317	16502559	142636104	120	10860										
BZW2	28969	broad.mit.edu	37	chr7	16745684	16745684	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cacttctttcttctctcctaGaatccgaatcggaaggtgag	8	11	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:16745684G>C	uc003stl.2	+	12	1410	c.1232_splice	c.e12-1	p.E411_splice	BZW2_uc003stm.2_Splice_Site_p.E217_splice|BZW2_uc003stj.2_Splice_Site_p.E411_splice|BZW2_uc003stk.2_Splice_Site_p.E335_splice|BZW2_uc003stp.2_Splice_Site_p.E259_splice|BZW2_uc010kua.2_Splice_Site_p.E370_splice	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2						cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		TTCTCTCCTAGAATCCGAATC	0.428													0	0	0	0.010504	0	20	59										C	16745684	G	C	16745684	5	2	42	1	0	0	0	0	0	0	1	0	1579	956	33	1	1273	1	BZW2	7	16745684	Splice_Site	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	243125	16745684	142392979	121	10861										
CDCA7L	55536	broad.mit.edu	37	chr7	21951271	21951271	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtctttccattcagatcactCtgcgtaaatcctgcaaaatc	5	12	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:21951271C>G	uc010kuk.2	-	3	387	c.267G>C	c.(265-267)CAG>CAC	p.Q89H	CDCA7L_uc003sve.3_Missense_Mutation_p.Q55H|CDCA7L_uc010kul.2_Intron|CDCA7L_uc003svf.3_Missense_Mutation_p.Q88H|CDCA7L_uc011jyk.1_Missense_Mutation_p.Q89H	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	89	PSIP1-binding.				positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						TCAGATCACTCTGCGTAAATC	0.388													0	0	0	0.01441	0	64	66										G	21951271	C	G	21951271	3	3	42	1	0	0	0	0	1	0	0	0	3091	912	32	1	1129	1	CDCA7L	7	21951271	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	5205587	21951271	137187392	122	10862										
AVL9	23080	broad.mit.edu	37	chr7	32623518	32623518	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gccaccagatgagaagccttGagcaaggcgtcagaggctgc	14	11	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:32623518G>C	uc003tcv.1	+	16	2092	c.1946G>C	c.(1945-1947)TGA>TCA	p.*649S	AVL9_uc011kai.1_Intron|uc003tcw.2_Intron|AVL9_uc010kwj.1_Missense_Mutation_p.E433Q	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	649						integral to membrane					0						GAGAAGCCTTGAGCAAGGCGT	0.522													0	0	0	0.00308	0	8	31										C	32623518	G	C	32623518	4	2	42	1	0	0	0	0	0	0	0	0	1228	1285	45	1	2008	1	AVL9	7	32623518	Nonstop_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10672247	32623518	126515145	123	10863										
PKD1L1	168507	broad.mit.edu	37	chr7	47894544	47894544	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaattcaatttctatctgtaGagattcctgggggttttcgg	10	6	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:47894544G>C	uc003tny.1	-	30	4795	c.4795C>G	c.(4795-4797)CTA>GTA	p.L1599V		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1599	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TCTATCTGTAGAGATTCCTGG	0.398													0	0	0	0.01441	0	50	43										C	47894544	G	C	47894544	3	2	42	1	0	0	0	0	1	0	0	0	11964	933	33	1	3866	1	PKD1L1	7	47894544	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	15271026	47894544	111244119	124	10864										
DDC	1644	broad.mit.edu	37	chr7	50595941	50595941	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggatggcttttaatttcactCcaccaattaacccagctctt	5	12	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:50595941C>G	uc003tpf.3	-	6	694	c.608G>C	c.(607-609)GGA>GCA	p.G203A	DDC_uc010kza.2_Missense_Mutation_p.G118A|DDC_uc003tpg.3_Missense_Mutation_p.G203A	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	203					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TAATTTCACTCCACCAATTAA	0.527													0	0	0	0.007291	0	29	102										G	50595941	C	G	50595941	3	3	42	1	0	0	0	0	1	0	0	0	4325	855	30	1	870	1	DDC	7	50595941	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2701397	50595941	108542722	125	10865										
ZNF713	349075	broad.mit.edu	37	chr7	55991305	55991305	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tactcctgtgaatagggtatCagctttgtaagccagaggta	11	7	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:55991305C>G	uc003trc.1	+	3	219	c.181C>G	c.(181-183)CAG>GAG	p.Q61E	ZNF713_uc003tra.1_Missense_Mutation_p.Q74E|MRPS17_uc003trb.2_Missense_Mutation_p.Q61E	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			aatagggtatcagctttgtaa	0.214													0	0	0	0.00308	0	8	10										G	55991305	C	G	55991305	3	3	42	1	0	0	0	0	1	0	0	0	18114	827	29	1	191	1	ZNF713	7	55991305	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	5395364	55991305	103147358	126	10866										
ZNF735	730291	broad.mit.edu	37	chr7	63673568	63673568	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttatatagagatgtgatgttAgagaactacagaaacctgtt	9	4	0	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:63673568A>G	uc011kdn.1	+	2	138	c.138A>G	c.(136-138)TTA>TTG	p.L46L		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGTGATGTTAGAGAACTACA	0.393													0	0	0	0.004007	0	16	36										G	63673568	A	G	63673568	2	3	42	1	0	0	0	0	0	0	0	1	18121	417	15	5		5	ZNF735	7	63673568	Silent	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	7682263	63673568	95465095	127	10867										
AUTS2	26053	broad.mit.edu	37	chr7	70255708	70255708	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgagcacacgcggctccactCcgtgcaccccgcctccctcg	9	22	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:70255708C>G	uc003tvw.3	+	19	4249	c.3506C>G	c.(3505-3507)TCC>TGC	p.S1169C	AUTS2_uc003tvx.3_Missense_Mutation_p.S1145C|AUTS2_uc011keg.1_Missense_Mutation_p.S621C	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1169	His-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CGGCTCCACTCCGTGCACCCC	0.701													0	0	0	0.003755	0	32	110										G	70255708	C	G	70255708	3	3	42	1	0	0	0	0	1	0	0	0	1225	855	30	1	3725	1	AUTS2	7	70255708	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	6582140	70255708	88882955	128	10868										
PCLO	27445	broad.mit.edu	37	chr7	82546033	82546033	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagaatcttggctcgtgccaTtgtgttggttctgcagatcc	12	9	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:82546033T>C	uc003uhx.2	-	7	11558	c.11269A>G	c.(11269-11271)ATG>GTG	p.M3757V	PCLO_uc003uhv.2_Missense_Mutation_p.M3757V|PCLO_uc010lec.2_Missense_Mutation_p.M722V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3688					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCTCGTGCCATTGTGTTGGTT	0.473													0	0	0	0.005443	0	26	31										C	82546033	T	C	82546033	3	2	42	1	0	0	0	0	1	0	0	0	11583	1493	52	5	4252	5	PCLO	7	82546033	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	12290325	82546033	76592630	129	10869										
GRM3	2913	broad.mit.edu	37	chr7	86468800	86468800	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttccttcgctatctgttactCagccctgctgaccaagacaa	6	14	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:86468800C>G	uc003uid.2	+	4	3069	c.1970C>G	c.(1969-1971)TCA>TGA	p.S657*	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Nonsense_Mutation_p.S529*|GRM3_uc010leh.2_Nonsense_Mutation_p.S249*	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	657	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ATCTGTTACTCAGCCCTGCTG	0.522													0	0	0	0.005524	0	38	111										G	86468800	C	G	86468800	4	3	42	1	0	0	0	0	0	1	0	0	6798	838	29	1	1980	1	GRM3	7	86468800	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3922767	86468800	72669863	130	10870										
DBF4	10926	broad.mit.edu	37	chr7	87537236	87537236	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaaatctggaaccaaatgctGaatttgataaaagaactgaa	7	5	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:87537236G>A	uc003ujf.1	+	12	2287	c.1783G>A	c.(1783-1785)GAA>AAA	p.E595K	DBF4_uc003ujh.1_Missense_Mutation_p.E335K|DBF4_uc003ujg.1_Missense_Mutation_p.E371K|DBF4_uc011khf.1_Missense_Mutation_p.E362K	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	595					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				ACCAAATGCTGAATTTGATAA	0.308													0	0	0	0.007835	0	39	45										A	87537236	G	A	87537236	3	1	42	1	0	0	0	0	1	0	0	0	4248	1291	45	1	1829	1	DBF4	7	87537236	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1068436	87537236	71601427	131	10871										
ADAM22	53616	broad.mit.edu	37	chr7	87778343	87778343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagtaaatgattgtgatattCgtgaaacgtgctcaggaaat	10	5	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:87778343C>T	uc003ujn.2	+	18	1616	c.1537C>T	c.(1537-1539)CGT>TGT	p.R513C	ADAM22_uc003ujk.1_Missense_Mutation_p.R513C|ADAM22_uc003ujl.1_Missense_Mutation_p.R513C|ADAM22_uc003ujm.2_Missense_Mutation_p.R513C|ADAM22_uc003ujo.2_Missense_Mutation_p.R513C|ADAM22_uc003ujp.1_Missense_Mutation_p.R565C	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	513	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TTGTGATATTCGTGAAACGTG	0.383													0	0	0	0.001984	0	6	29										T	87778343	C	T	87778343	3	4	42	1	0	0	0	0	1	0	0	0	244	884	31	1	1607	1	ADAM22	7	87778343	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	241107	87778343	71360320	132	10872										
STEAP4	79689	broad.mit.edu	37	chr7	87913437	87913437	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggtggtcttctgggggtttcGacttccaaaaacaacagaat	11	8	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:87913437G>A	uc003ujs.2	-	2	253	c.148C>T	c.(148-150)CGA>TGA	p.R50*	STEAP4_uc010lek.2_Nonsense_Mutation_p.R50*|STEAP4_uc003ujt.2_Nonsense_Mutation_p.R50*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	50					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TGGGGGTTTCGACTTCCAAAA	0.438													0	0	0	0.01441	0	55	55										A	87913437	G	A	87913437	4	1	42	1	0	0	0	0	0	1	0	0	15279	1066	37	1	1247	1	STEAP4	7	87913437	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	135094	87913437	71225226	133	10873										
SAMD9	54809	broad.mit.edu	37	chr7	92734156	92734156	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgtttgatctgggtggcattTatttgttacaagaatgtact	10	4	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:92734156T>C	uc003umf.2	-	3	1511	c.1255A>G	c.(1255-1257)AAA>GAA	p.K419E	SAMD9_uc003umg.2_Missense_Mutation_p.K419E	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	419						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GGGTGGCATTTATTTGTTACA	0.328													0	0	0	0.008871	0	20	16										C	92734156	T	C	92734156	3	2	42	1	0	0	0	0	1	0	0	0	13826	1763	61	5	3518	5	SAMD9	7	92734156	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	4820719	92734156	66404507	134	10874										
PTPRZ1	5803	broad.mit.edu	37	chr7	121652861	121652861	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcctacttctcatatgcactCtgcttcacttcaaggtttga	6	12	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:121652861C>G	uc003vjy.2	+	12	4156	c.3761C>G	c.(3760-3762)TCT>TGT	p.S1254C	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1254	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CATATGCACTCTGCTTCACTT	0.388													0	0	0	0.013114	0	46	64										G	121652861	C	G	121652861	3	3	42	1	0	0	0	0	1	0	0	0	12814	913	32	1	3807	1	PTPRZ1	7	121652861	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	28918705	121652861	37485802	135	10875										
STRA8	346673	broad.mit.edu	37	chr7	134925346	134925346	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agctgccagcacagctgcagGagcttgagcatcgggtggcc	15	12	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:134925346G>C	uc011kpx.1	+	2	136	c.136G>C	c.(136-138)GAG>CAG	p.E46Q		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	46					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						ACAGCTGCAGGAGCTTGAGCA	0.552													0	0	0	0.003755	0	26	117										C	134925346	G	C	134925346	3	2	42	1	0	0	0	0	1	0	0	0	15322	1175	41	1	142	1	STRA8	7	134925346	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	13272485	134925346	24213317	136	10876										
RBM33	155435	broad.mit.edu	37	chr7	155511101	155511101	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cccttgctaccagttccgagCcagccgagacctgccgtggg	12	16	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:155511101C>G	uc010lqk.1	+	9	1592	c.1224C>G	c.(1222-1224)AGC>AGG	p.S408R	RBM33_uc011kvv.1_Missense_Mutation_p.S217R	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	408	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CAGTTCCGAGCCAGCCGAGAC	0.458													0	0	0	0.004007	0	15	65										G	155511101	C	G	155511101	3	3	42	1	0	0	0	0	1	0	0	0	13130	738	26	4	1258	4	RBM33	7	155511101	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	20585755	155511101	3627562	137	10877										
VIPR2	7434	broad.mit.edu	37	chr7	158824561	158824561	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aggacggccaccaccaggccCtgcaatgagaagagatggtc	13	12	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:158824561C>T	uc003woh.2	-	12	1288	c.1102_splice	c.e12-1	p.G368_splice	VIPR2_uc010lqx.2_Splice_Site	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2						cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CCACCAGGCCCTGCAATGAGA	0.597													0	0	0	0.01441	0	92	61										T	158824561	C	T	158824561	5	4	42	1	0	0	0	0	0	0	1	0	17167	695	24	2	223	2	VIPR2	7	158824561	Splice_Site	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3313460	158824561	314102	138	10878										
FBXO25	26260	broad.mit.edu	37	chr8	385664	385664	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctttaatcggttagacttctCaagtgcaattcaagatatcc	6	9	2	2	rs140242296	byFrequency	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:385664C>G	uc003wox.2	+	5	604	c.338C>G	c.(337-339)TCA>TGA	p.S113*	FBXO25_uc003woy.2_Nonsense_Mutation_p.S113*|FBXO25_uc003woz.2_Nonsense_Mutation_p.S46*|FBXO25_uc003wpa.2_5'UTR	NM_183421	NP_904357	Q8TCJ0	FBX25_HUMAN	F-box only protein 25 isoform 1	113						nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			lung(1)	1		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		TTAGACTTCTCAAGTGCAATT	0.348													0	0	0	0.01441	0	49	40										G	385664	C	G	385664	4	3	42	1	0	0	0	0	0	1	0	0	5736	838	29	1	352	1	FBXO25	8	385664	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		385664	145978358	139	10879										
CSMD1	64478	broad.mit.edu	37	chr8	3141781	3141781	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agggcggagccactccactcCttcagcaggatgtcactgtc	11	14	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:3141781C>A	uc011kwk.1	-	26	4431	c.4041G>T	c.(4039-4041)AAG>AAT	p.K1347N	CSMD1_uc011kwj.1_Missense_Mutation_p.K739N|CSMD1_uc003wqe.2_Missense_Mutation_p.K503N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1347	Extracellular (Potential).|CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACTCCACTCCTTCAGCAGGA	0.557											OREG0018505	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	6.31663e-08	0.003163	6.50241e-08	15	19										A	3141781	C	A	3141781	3	1	42	1	0	0	0	0	1	0	0	0	3944	680	24	4	6836	4	CSMD1	8	3141781	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2756117	3141781	143222241	140	10880										
XPO7	23039	broad.mit.edu	37	chr8	21840321	21840321	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gaatctgtgcacatcatactGaggtaaggaaacttagcctc	9	9	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:21840321G>A	uc003xaa.3	+	11	1377	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	XPO7_uc010lti.2_Silent_p.L434L|XPO7_uc010ltk.2_Silent_p.L426L	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	425				Missing (in Ref. 3; BAA34465).	mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		ACATCATACTGAGGTAAGGAA	0.507													0	0	0	0.00623	0	40	45										A	21840321	G	A	21840321	2	1	42	1	0	0	0	0	0	0	0	1	17446	1277	45	1		1	XPO7	8	21840321	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	18698540	21840321	124523701	141	10881										
HR	55806	broad.mit.edu	37	chr8	21978464	21978464	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgtccaggatgttggtgatgCggtcatcctgcagagagggg	17	7	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:21978464C>A	uc003xas.2	-	11	3040	c.2375G>T	c.(2374-2376)CGC>CTC	p.R792L	HR_uc003xat.2_Missense_Mutation_p.R792L	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	792							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GTTGGTGATGCGGTCATCCTG	0.672													1	0	1.9806e-07	0.014323	2.03425e-07	23	25										A	21978464	C	A	21978464	3	1	42	1	0	0	0	0	1	0	0	0	7347	768	27	4	1230	4	HR	8	21978464	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	138143	21978464	124385558	142	10882										
BMP1	649	broad.mit.edu	37	chr8	22035399	22035399	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcctgaagatggagcctcaGgaggtggagtccctggggga	17	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:22035399G>A	uc003xbg.2	+	6	1009	c.765G>A	c.(763-765)CAG>CAA	p.Q255Q	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Silent_p.Q255Q|BMP1_uc003xbb.2_Silent_p.Q255Q|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.Q4Q|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.Q4Q|BMP1_uc011kzc.1_Silent_p.Q4Q|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	255	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TGGAGCCTCAGGAGGTGGAGT	0.592													0	0	0	0.01441	0	102	369										A	22035399	G	A	22035399	2	1	42	1	0	0	0	0	0	0	0	1	1456	991	35	2		2	BMP1	8	22035399	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	56935	22035399	124328623	143	10883										
ADRA1A	148	broad.mit.edu	37	chr8	26722121	26722121	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcacgccgatgtagcggtcGatggagatgatgcagaggcc	15	10	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:26722121G>C	uc003xfh.1	-	1	802	c.366C>G	c.(364-366)ATC>ATG	p.I122M	ADRA1A_uc003xfc.1_Missense_Mutation_p.I122M|ADRA1A_uc010lul.1_Missense_Mutation_p.I122M|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.I122M|ADRA1A_uc010lum.1_Missense_Mutation_p.I122M|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.I122M	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	122	Helical; Name=3; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	TGTAGCGGTCGATGGAGATGA	0.627													0	0	0	0.01441	0	102	100										C	26722121	G	C	26722121	3	2	42	1	0	0	0	0	1	0	0	0	334	1048	37	1	1333	1	ADRA1A	8	26722121	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	4686722	26722121	119641901	144	10884										
NRG1	3084	broad.mit.edu	37	chr8	31498210	31498210	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggagacgggccggaacctcaAgaaggaggtcagccgggtgc	18	10	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:31498210A>G	uc003xip.2	+	1	943	c.710A>G	c.(709-711)AAG>AGG	p.K237R		NM_013962	NP_039256	Q02297	NRG1_HUMAN	neuregulin 1 isoform GGF2	22	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CGGAACCTCAAGAAGGAGGTC	0.701													0	0	0	0.006214	0	7	37										G	31498210	A	G	31498210	3	3	42	1	0	0	0	0	1	0	0	0	10647	72	3	5	712	5	NRG1	8	31498210	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	4776089	31498210	114865812	145	10885										
KCNU1	157855	broad.mit.edu	37	chr8	36644882	36644882	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagaagcctccacttccaggGacaatttcgtgatcatatag	8	10	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:36644882G>A	uc010lvw.2	+	2	341	c.254G>A	c.(253-255)GGA>GAA	p.G85E	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	85	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CACTTCCAGGGACAATTTCGT	0.423													0	0	0	0.013537	0	13	12										A	36644882	G	A	36644882	3	1	42	1	0	0	0	0	1	0	0	0	8093	1174	41	1	260	1	KCNU1	8	36644882	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	5146672	36644882	109719140	146	10886										
ANK1	286	broad.mit.edu	37	chr8	41519393	41519393	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caggggcccctctacagtcaCctcctcgtgctcctgggcgg	12	17	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:41519393C>G	uc003xok.2	-	41	5629	c.5545G>C	c.(5545-5547)GTG>CTG	p.V1849L	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Splice_Site_p.E1002_splice|ANK1_uc003xoi.2_Splice_Site_p.E1848_splice|ANK1_uc003xoj.2_Splice_Site_p.E1848_splice|ANK1_uc003xol.2_Missense_Mutation_p.V1687L|ANK1_uc003xom.2_Splice_Site_p.E1889_splice|ANK1_uc011lcl.1_Splice_Site_p.E123_splice|ANK1_uc003xod.2_Splice_Site_p.E123_splice|ANK1_uc003xoc.2_Missense_Mutation_p.V124L|ANK1_uc003xof.2_Intron|MIR486_hsa-mir-486|MI0002470_5'Flank	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1849	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTACAGTCACCTCCTCGTGC	0.582													0	0	0	0.011902	0	46	385										G	41519393	C	G	41519393	3	3	42	1	0	0	0	0	1	0	0	0	620	521	18	4	211	4	ANK1	8	41519393	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4874511	41519393	104844629	147	10887										
KIAA0146	23514	broad.mit.edu	37	chr8	48626144	48626144	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcctgtgagctgcctggccCggtgatgctcgacagcctgg	14	13	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:48626144C>A	uc003xqd.2	+	16	2291	c.2282C>A	c.(2281-2283)CCG>CAG	p.P761Q	KIAA0146_uc011ldc.1_Missense_Mutation_p.P691Q|KIAA0146_uc011ldd.1_Missense_Mutation_p.P701Q|KIAA0146_uc003xqe.2_Missense_Mutation_p.P236Q|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc010lxt.2_Missense_Mutation_p.P450Q|KIAA0146_uc011ldf.1_Missense_Mutation_p.P266Q|KIAA0146_uc011ldg.1_Missense_Mutation_p.P251Q|KIAA0146_uc003xqg.1_RNA	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	761											0		Lung NSC(58;0.175)				CTGCCTGGCCCGGTGATGCTC	0.527													1	0	4.7796e-09	0.004656	4.9538e-09	24	100										A	48626144	C	A	48626144	3	1	42	1	0	0	0	0	1	0	0	0	8157	652	23	4	2344	4	KIAA0146	8	48626144	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	7106751	48626144	97737878	148	10888										
PRKDC	5591	broad.mit.edu	37	chr8	48719847	48719847	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	catactattatcttctggaaGaggggtaagcttctcctcta	8	9	4	1	rs150449253	by1000genomes	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:48719847G>C	uc003xqi.2	-	70	9655	c.9598C>G	c.(9598-9600)CTT>GTT	p.L3200V	PRKDC_uc003xqj.2_Missense_Mutation_p.L3200V|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3200	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TCTTCTGGAAGAGGGGTAAGC	0.438								NHEJ					0	0	0	0.004656	0	27	130										C	48719847	G	C	48719847	3	2	42	1	0	0	0	0	1	0	0	0	12521	942	33	1	2860	1	PRKDC	8	48719847	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	93703	48719847	97644175	149	10889										
PRKDC	5591	broad.mit.edu	37	chr8	48815271	48815271	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgctgctgtggtgttatttGcttaatggaccatttaagga	11	6	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:48815271G>C	uc003xqi.2	-	27	3184	c.3127C>G	c.(3127-3129)CAA>GAA	p.Q1043E	PRKDC_uc003xqj.2_Missense_Mutation_p.Q1043E|PRKDC_uc011ldh.1_Missense_Mutation_p.Q1043E	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1043					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGTGTTATTTGCTTAATGGAC	0.423								NHEJ					0	0	0	0.001984	0	7	54										C	48815271	G	C	48815271	3	2	42	1	0	0	0	0	1	0	0	0	12521	1328	46	4	9498	4	PRKDC	8	48815271	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	95424	48815271	97548751	150	10890										
YTHDF3	253943	broad.mit.edu	37	chr8	64099876	64099876	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acatcgttccattaaatactCtatctggtgtagtactgagc	7	9	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:64099876C>G	uc003xuy.2	+	5	1623	c.1307C>G	c.(1306-1308)TCT>TGT	p.S436C	YTHDF3_uc010lys.2_Missense_Mutation_p.S380C|YTHDF3_uc003xuz.2_Missense_Mutation_p.S380C|YTHDF3_uc003xva.2_Missense_Mutation_p.S380C|YTHDF3_uc011len.1_Missense_Mutation_p.S380C	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	436	YTH.										0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			ATTAAATACTCTATCTGGTGT	0.398													0	0	0	0.004656	0	25	88										G	64099876	C	G	64099876	3	3	42	1	0	0	0	0	1	0	0	0	17497	912	32	1	1320	1	YTHDF3	8	64099876	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	15284605	64099876	82264146	151	10891										
PREX2	80243	broad.mit.edu	37	chr8	68931794	68931794	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttatttacagatgttgttctCaaacattgaagacatccttg	6	7	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:68931794C>G	uc003xxv.1	+	3	251	c.224C>G	c.(223-225)TCA>TGA	p.S75*	PREX2_uc003xxu.1_Nonsense_Mutation_p.S75*|PREX2_uc011lez.1_Intron	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	75	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ATGTTGTTCTCAAACATTGAA	0.363													0	0	0	0.016522	0	23	12										G	68931794	C	G	68931794	4	3	42	1	0	0	0	0	0	1	0	0	12477	838	29	1	234	1	PREX2	8	68931794	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4831918	68931794	77432228	152	10892										
TRPA1	8989	broad.mit.edu	37	chr8	72973899	72973899	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gacatccatcggttgtgttaAcaatatccacgctaccagaa	7	11	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:72973899A>G	uc003xza.2	-	7	1080	c.905T>C	c.(904-906)GTT>GCT	p.V302A		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	302	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GGTTGTGTTAACAATATCCAC	0.428													0	0	0	0.015359	0	31	107										G	72973899	A	G	72973899	3	3	42	1	0	0	0	0	1	0	0	0	16574	43	2	5	2538	5	TRPA1	8	72973899	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	4042105	72973899	73390123	153	10893										
ZFHX4	79776	broad.mit.edu	37	chr8	77616680	77616680	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagagcgagatcagcgagttAgaggacagtgacgtggaaaa	16	5	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:77616680A>C	uc003yav.2	+	2	744	c.357A>C	c.(355-357)TTA>TTC	p.L119F	ZFHX4_uc003yat.1_Missense_Mutation_p.L119F|ZFHX4_uc003yau.1_Missense_Mutation_p.L119F|ZFHX4_uc003yaw.1_Missense_Mutation_p.L119F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	119						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCAGCGAGTTAGAGGACAGTG	0.483										HNSCC(33;0.089)			0	0	0	0.003954	0	25	177										C	77616680	A	C	77616680	3	2	42	1	0	0	0	0	1	0	0	0	17632	417	15	5	359	5	ZFHX4	8	77616680	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	4642781	77616680	68747342	154	10894										
PKHD1L1	93035	broad.mit.edu	37	chr8	110477234	110477234	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tggggtctgcattttgcacaGcaaaaggcctggttctccca	11	11	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:110477234G>T	uc003yne.2	+	49	8277	c.8173G>T	c.(8173-8175)GCA>TCA	p.A2725S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2725	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTGCACAGCAAAAGGCCT	0.468										HNSCC(38;0.096)			1	0	1.57351e-24	0.003755	1.68063e-24	36	149										T	110477234	G	T	110477234	3	4	42	1	0	0	0	0	1	0	0	0	11972	971	34	4	8367	4	PKHD1L1	8	110477234	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	32860554	110477234	35886788	155	10895										
LRRC6	23639	broad.mit.edu	37	chr8	133623595	133623595	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcacatcaacatcgattaaaGaggtatccatataccttcaa	5	10	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:133623595G>C	uc003ytk.2	-	9	1063	c.989C>G	c.(988-990)TCT>TGT	p.S330C	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	330	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCGATTAAAGAGGTATCCAT	0.313													0	0	0	0.003954	0	24	26										C	133623595	G	C	133623595	3	2	42	1	0	0	0	0	1	0	0	0	9016	942	33	1	427	1	LRRC6	8	133623595	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	23146361	133623595	12740427	156	10896										
PHF20L1	51105	broad.mit.edu	37	chr8	133844494	133844494	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttgcagactattcagactatGaagacagttccctcgaattt	7	9	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:133844494G>T	uc003ytt.2	+	15	2084	c.1759G>T	c.(1759-1761)GAA>TAA	p.E587*	PHF20L1_uc011lja.1_Nonsense_Mutation_p.E561*	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	587							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTCAGACTATGAAGACAGTTC	0.368													1	0	1.45978e-39	0.01441	1.58143e-39	70	65										T	133844494	G	T	133844494	4	4	42	1	0	0	0	0	0	1	0	0	11832	1291	45	3	1909	3	PHF20L1	8	133844494	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	220899	133844494	12519528	157	10897										
PTPRD	5789	broad.mit.edu	37	chr9	8521491	8521491	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtgatattaacgcttccgccTggcatgatttcatgattagt	9	8	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:8521491T>A	uc003zkk.2	-	19	1458	c.747A>T	c.(745-747)CCA>CCT	p.P249P	PTPRD_uc003zkp.2_Silent_p.P249P|PTPRD_uc003zkq.2_Silent_p.P249P|PTPRD_uc003zkr.2_Silent_p.P243P|PTPRD_uc003zks.2_Silent_p.P239P|PTPRD_uc003zkl.2_Silent_p.P249P|PTPRD_uc003zkm.2_Silent_p.P236P|PTPRD_uc003zkn.2_Silent_p.P249P|PTPRD_uc003zko.2_Silent_p.P246P	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	249	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CGCTTCCGCCTGGCATGATTT	0.468										TSP Lung(15;0.13)			0	0	0	0.012319	0	22	61										A	8521491	T	A	8521491	2	1	42	1	0	0	0	0	0	0	0	1	12799	1567	55	5		5	PTPRD	9	8521491	Silent	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08		8521491	132691940	158	10898										
RPS6	6194	broad.mit.edu	37	chr9	19376356	19376356	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggaaagtctgcgtctcttcgCaatttgttcctggcgcttct	10	11	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:19376356C>A	uc003znv.1	-	6	727	c.685G>T	c.(685-687)GCG>TCG	p.A229S	RPS6_uc003znu.1_Missense_Mutation_p.A198S	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	229					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		CGTCTCTTCGCAATTTGTTCC	0.413													1	0	1.62565e-12	0.012213	1.70039e-12	32	119										A	19376356	C	A	19376356	3	1	42	1	0	0	0	0	1	0	0	0	13649	710	25	4	68	4	RPS6	9	19376356	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	10854865	19376356	121837075	159	10899										
TEK	7010	broad.mit.edu	37	chr9	27169599	27169599	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ataggaggaaacctcttcacCtcggccttcaccaggctgat	9	13	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:27169599C>T	uc003zqi.3	+	4	1042	c.600C>T	c.(598-600)ACC>ACT	p.T200T	TEK_uc010mjc.1_Silent_p.T53T|TEK_uc011lnn.1_Silent_p.T200T|TEK_uc011lno.1_Silent_p.T200T|TEK_uc011lnp.1_Silent_p.T96T|TEK_uc003zqj.1_Silent_p.T177T	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	200	Extracellular (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACCTCTTCACCTCGGCCTTCA	0.448													0	0	0	0.00499	0	18	82										T	27169599	C	T	27169599	2	4	42	1	0	0	0	0	0	0	0	1	15748	668	24	2		2	TEK	9	27169599	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	7793243	27169599	114043832	160	10900										
ZBTB5	9925	broad.mit.edu	37	chr9	37441201	37441201	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acctgcaggcccagcctctgGactcaacaaatagggggcct	11	14	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:37441201G>C	uc003zzx.2	-	2	1548	c.1348C>G	c.(1348-1350)CCA>GCA	p.P450A		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		CCAGCCTCTGGACTCAACAAA	0.517													0	0	0	0.007291	0	28	52										C	37441201	G	C	37441201	3	2	42	1	0	0	0	0	1	0	0	0	17548	1174	41	1	689	1	ZBTB5	9	37441201	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10271602	37441201	103772230	161	10901										
TRPM6	140803	broad.mit.edu	37	chr9	77376977	77376977	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atctaaaactatgactcctaGcgaagggcctgtatctgcgg	10	10	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:77376977G>A	uc004ajl.1	-	26	4848	c.4610C>T	c.(4609-4611)GCT>GTT	p.A1537V	TRPM6_uc004ajk.1_Missense_Mutation_p.A1532V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.A493V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1537	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ATGACTCCTAGCGAAGGGCCT	0.413													0	0	0	0.00632	0	28	15										A	77376977	G	A	77376977	3	1	42	1	0	0	0	0	1	0	0	0	16587	971	34	2	1514	2	TRPM6	9	77376977	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	39935776	77376977	63836454	162	10902										
C9orf64	84267	broad.mit.edu	37	chr9	86571141	86571141	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acccactgtatgttttccctCtgtacctcaccacacacttg	4	16	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:86571141C>G	uc004anb.2	-	1	523	c.275G>C	c.(274-276)AGA>ACA	p.R92T	C9orf64_uc004anc.2_5'UTR	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	92											0						TGTTTTCCCTCTGTACCTCAC	0.592													0	0	0	0.01441	0	84	59										G	86571141	C	G	86571141	3	3	42	1	0	0	0	0	1	0	0	0	2489	913	32	1	766	1	C9orf64	9	86571141	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	9194164	86571141	54642290	163	10903										
FAM22G	441457	broad.mit.edu	37	chr9	99697725	99697725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttgaccggatgattttctacGagatggcggcaaagtgagtc	13	7	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:99697725G>A	uc004awq.1	+	3	1544	c.829G>A	c.(829-831)GAG>AAG	p.E277K	HIATL2_uc004awr.1_Intron	NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	277										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GATTTTCTACGAGATGGCGGC	0.652													0	0	0	0.005524	0	40	73										A	99697725	G	A	99697725	3	1	42	1	0	0	0	0	1	0	0	0	5546	1059	37	1	839	1	FAM22G	9	99697725	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	13126584	99697725	41515706	164	10904										
BAAT	570	broad.mit.edu	37	chr9	104130470	104130470	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atctgttacttctggtttgcGgggcaggtcttcatagttat	11	7	4	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:104130470G>A	uc010mtd.2	-	3	710	c.601C>T	c.(601-603)CGC>TGC	p.R201C	BAAT_uc004bbd.3_Missense_Mutation_p.R201C	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	201					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	TCTGGTTTGCGGGGCAGGTCT	0.493													0	0	0	0.008871	0	17	56										A	104130470	G	A	104130470	3	1	42	1	0	0	0	0	1	0	0	0	1280	1116	39	2	663	2	BAAT	9	104130470	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	4432745	104130470	37082961	165	10905										
OR1J1	347168	broad.mit.edu	37	chr9	125239256	125239256	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcagcctcccaaagtgttgAgattacaggcatgagccact	9	12	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:125239256A>G	uc011lyu.1	-	1	950	c.950T>C	c.(949-951)CTC>CCC	p.L317P	OR1J2_uc004bmj.1_Intron	NM_001004451	NP_001004451	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J,	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						caaagtgttgagattacaggc	0.124													0	0	0	0.001984	0	6	50										G	125239256	A	G	125239256	3	3	42	1	0	0	0	0	1	0	0	0	10959	304	11	5	21	5	OR1J1	9	125239256	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	21108786	125239256	15974175	166	10906										
SPTAN1	6709	broad.mit.edu	37	chr9	131346653	131346653	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagaagaaacaggaagccctCgtggctcgctatgaggcact	12	10	0	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:131346653C>T	uc004bvl.3	+	17	2399	c.2286C>T	c.(2284-2286)CTC>CTT	p.L762L	SPTAN1_uc011mbg.1_Silent_p.L762L|SPTAN1_uc011mbh.1_Silent_p.L774L|SPTAN1_uc004bvm.3_Silent_p.L762L|SPTAN1_uc004bvn.3_Silent_p.L762L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	762	Spectrin 8.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGGAAGCCCTCGTGGCTCGCT	0.547													0	0	0	0.005443	0	25	9										T	131346653	C	T	131346653	2	4	42	1	0	0	0	0	0	0	0	1	15116	871	31	1		1	SPTAN1	9	131346653	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	6107397	131346653	9866778	167	10907										
SPTAN1	6709	broad.mit.edu	37	chr9	131347041	131347041	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agaatctgctaaagaaacatCaagccttacaagcagaaatt	6	8	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:131347041C>T	uc004bvl.3	+	18	2592	c.2479C>T	c.(2479-2481)CAA>TAA	p.Q827*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.Q827*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.Q839*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.Q827*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.Q827*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	827	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AAAGAAACATCAAGCCTTACA	0.448													0	0	0	0.01441	0	59	25										T	131347041	C	T	131347041	4	4	42	1	0	0	0	0	0	1	0	0	15116	827	29	1	2545	1	SPTAN1	9	131347041	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	388	131347041	9866390	168	10908										
SEC16A	9919	broad.mit.edu	37	chr9	139368716	139368716	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagagacacgctagaggactGaggaggccgagggggcagct	18	9	0	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:139368716G>T	uc004chx.2	-	3	3661	c.3352C>A	c.(3352-3354)CAG>AAG	p.Q1118K	SEC16A_uc004chv.3_Missense_Mutation_p.Q508K|SEC16A_uc004chw.2_Missense_Mutation_p.Q1118K|SEC16A_uc010nbn.2_Missense_Mutation_p.Q1118K|SEC16A_uc010nbo.1_Missense_Mutation_p.Q1118K	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	940	Pro-rich.|Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CTAGAGGACTGAGGAGGCCGA	0.667													1	0	4.31634e-10	0.012213	4.49413e-10	26	20										T	139368716	G	T	139368716	3	4	42	1	0	0	0	0	1	0	0	0	13986	1299	45	3	3841	3	SEC16A	9	139368716	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	8021675	139368716	1844715	169	10909										
TUBB8	347688	broad.mit.edu	37	chr10	93965	93965	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcagtcacagctctcagcctCctttctgacaacgtccatca	6	16	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:93965C>G	uc001ifi.2	-	4	367	c.367G>C	c.(367-369)GAG>CAG	p.E123Q	TUBB8_uc009xhe.2_Missense_Mutation_p.E86Q|TUBB8_uc010pzs.1_Missense_Mutation_p.E51Q	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	123					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		CTCTCAGCCTCCTTTCTGACA	0.597													0	0	0	0.004007	0	12	167										G	93965	C	G	93965	3	3	42	1	0	0	0	0	1	0	0	0	16758	864	30	1	971	1	TUBB8	10	93965	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		93965	135440782	170	10910										
FRMD4A	55691	broad.mit.edu	37	chr10	13698803	13698803	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tggaacgctggtaccactggCgcagctcgtctgagacggcg	15	12	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:13698803C>T	uc001ims.2	-	22	3138	c.2786G>A	c.(2785-2787)CGC>CAC	p.R929H	FRMD4A_uc009xjf.1_Missense_Mutation_p.R929H	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	929						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GTACCACTGGCGCAGCTCGTC	0.711													0	0	0	0.010729	0	10	72										T	13698803	C	T	13698803	3	4	42	1	0	0	0	0	1	0	0	0	6051	768	27	2	345	2	FRMD4A	10	13698803	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	13604838	13698803	121835944	171	10911										
ZNF33B	7582	broad.mit.edu	37	chr10	43088106	43088106	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgtgttctctgatgtacaatGagatttgacttttgagagaa	10	4	1	5			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:43088106G>A	uc001jaf.1	-	5	2407	c.2292C>T	c.(2290-2292)CTC>CTT	p.L764L	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Silent_p.L652L|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	764	C2H2-type 16.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GATGTACAATGAGATTTGACT	0.393													0	0	0	0.009535	0	30	229										A	43088106	G	A	43088106	2	1	42	1	0	0	0	0	0	0	0	1	17852	1277	45	1		1	ZNF33B	10	43088106	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	29389303	43088106	92446641	172	10912										
MYPN	84665	broad.mit.edu	37	chr10	69925571	69925571	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agcattgcacagctgcacgtGagaggtaaggactctttaat	11	8	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:69925571G>C	uc001jnm.3	+	10	1781	c.1596G>C	c.(1594-1596)GTG>GTC	p.V532V	MYPN_uc001jnl.1_Silent_p.V532V|MYPN_uc001jnn.3_Silent_p.V257V|MYPN_uc001jno.3_Silent_p.V532V|MYPN_uc009xps.2_Silent_p.V532V|MYPN_uc009xpt.2_Silent_p.V532V|MYPN_uc010qit.1_Silent_p.V238V|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	532						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						AGCTGCACGTGAGAGGTAAGG	0.428													0	0	0	0.014323	0	18	117										C	69925571	G	C	69925571	2	2	42	1	0	0	0	0	0	0	0	1	10098	1277	45	1		1	MYPN	10	69925571	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	26837465	69925571	65609176	173	10913										
DDX21	9188	broad.mit.edu	37	chr10	70738718	70738718	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagtgaagggaatggtttttCtcaaaggaaagctggtaagg	14	3	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:70738718C>G	uc001jov.1	+	13	2113	c.2023C>G	c.(2023-2025)CTC>GTC	p.L675V	DDX21_uc001jow.1_Missense_Mutation_p.L607V	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	675						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						AATGGTTTTTCTCAAAGGAAA	0.458													0	0	0	0.003755	0	32	150										G	70738718	C	G	70738718	3	3	42	1	0	0	0	0	1	0	0	0	4349	913	32	1	2073	1	DDX21	10	70738718	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	813147	70738718	64796029	174	10914										
USP54	159195	broad.mit.edu	37	chr10	75279710	75279710	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcgactagggctctgctgtgCgtgctacagctggcaccatg	13	12	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:75279710C>A	uc001juo.2	-	17	2540	c.2523G>T	c.(2521-2523)ACG>ACT	p.T841T	USP54_uc010qkk.1_Silent_p.T23T|USP54_uc001juk.2_Intron|USP54_uc001jul.2_Intron|USP54_uc001jum.2_Intron|USP54_uc001jun.2_Intron|USP54_uc001jup.2_Silent_p.T841T	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	841					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					CTCTGCTGTGCGTGCTACAGC	0.378													1	0	2.56e-06	0.009096	2.61753e-06	4	45										A	75279710	C	A	75279710	2	1	42	1	0	0	0	0	0	0	0	1	17082	755	27	4		4	USP54	10	75279710	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4540992	75279710	60255037	175	10915										
KIAA0913	23053	broad.mit.edu	37	chr10	75548903	75548903	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cggatgagtttcagcgagggGatcagctcttccgcatgcgg	15	10	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:75548903G>A	uc009xrl.2	+	3	444	c.412G>A	c.(412-414)GAT>AAT	p.D138N	KIAA0913_uc001jve.2_Missense_Mutation_p.D138N|KIAA0913_uc001jvf.2_Missense_Mutation_p.D138N|KIAA0913_uc001jvh.2_5'Flank|KIAA0913_uc001jvi.2_5'Flank|KIAA0913_uc010qkr.1_5'Flank|KIAA0913_uc001jvj.2_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	138							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					TCAGCGAGGGGATCAGCTCTT	0.567													0	0	0	0.01441	0	65	67										A	75548903	G	A	75548903	3	1	42	1	0	0	0	0	1	0	0	0	8200	1174	41	1	422	1	KIAA0913	10	75548903	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	269193	75548903	59985844	176	10916										
LRIT1	26103	broad.mit.edu	37	chr10	85992365	85992365	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cctcctttgtgctgggcacaGagggtccagtggccaggaca	14	12	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:85992365G>C	uc001kcz.1	-	4	1212	c.1190C>G	c.(1189-1191)TCT>TGT	p.S397C		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	397	Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GCTGGGCACAGAGGGTCCAGT	0.617													0	0	0	0.004878	0	36	109										C	85992365	G	C	85992365	3	2	42	1	0	0	0	0	1	0	0	0	8947	942	33	1	685	1	LRIT1	10	85992365	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10443462	85992365	49542382	177	10917										
GRID1	2894	broad.mit.edu	37	chr10	87373287	87373287	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccggcgaagctgtgcagcttGagggatttgccgtcggcctg	16	11	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:87373287G>C	uc001kdl.1	-	15	2579	c.2478C>G	c.(2476-2478)CTC>CTG	p.L826L	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.L397L	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	826	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGTGCAGCTTGAGGGATTTGC	0.647										Multiple Myeloma(13;0.14)			0	0	0	0.010504	0	19	100										C	87373287	G	C	87373287	2	2	42	1	0	0	0	0	0	0	0	1	6771	1277	45	1		1	GRID1	10	87373287	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1380922	87373287	48161460	178	10918										
CH25H	9023	broad.mit.edu	37	chr10	90966884	90966884	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcacaggatatccaggaccaCgaagggcaggcaaaagccca	12	12	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:90966884C>T	uc001kfz.2	-	1	188	c.166G>A	c.(166-168)GTG>ATG	p.V56M		NM_003956	NP_003947	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	56	Helical; (Potential).				bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding				0		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		TCCAGGACCACGAAGGGCAGG	0.632													0	0	0	0.004007	0	15	53										T	90966884	C	T	90966884	3	4	42	1	0	0	0	0	1	0	0	0	3307	536	19	2	656	2	CH25H	10	90966884	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3593597	90966884	44567863	179	10919										
PPP1R3C	5507	broad.mit.edu	37	chr10	93390301	93390311	+	Frame_Shift_Del	DEL	GCAGATCCCAC	GCAGATCCCAC	-													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaggtccaagagatcaaactGcagatcccacgctggttctt							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:93390301_93390311delGCAGATCCCAC	uc001kho.2	-	2	459_469	c.327_337delGTGGGATCTGC	c.(325-339)GCGTGGGATCTGCAGfs	p.A109fs		NM_005398	NP_005389	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	109_113							protein serine/threonine phosphatase activity			breast(1)	1		Colorectal(252;0.235)				AGATCAAACTGCAGATCCCACGCTGGTTCTT	0.483																		104	81	---	---								-	93390311	GCAGATCCCAC	-	93390301	7	5	42	1	0	1	0	1	0	0	0	0	12373	1328	46	0	620	0	PPP1R3C	10	93390301	Frame_Shift_Del	DEL	GCAGATCCCAC	TCGA-DK-A1A6-01A-11D-A13W-08	2423417	93390301	42144446	180	10920										
SLIT1	6585	broad.mit.edu	37	chr10	98762697	98762697	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caaccgtggaagccggtgccGttgaggatctgccacaggcg	15	12	1	1	rs148583876		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:98762697G>A	uc001kmw.2	-	35	4170	c.3918C>T	c.(3916-3918)AAC>AAT	p.N1306N		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1306	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGCCGGTGCCGTTGAGGATCT	0.607													0	0	0	0.01441	0	69	331										A	98762697	G	A	98762697	2	1	42	1	0	0	0	0	0	0	0	1	14739	1136	40	2		2	SLIT1	10	98762697	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	5372396	98762697	36772050	181	10921										
SLIT1	6585	broad.mit.edu	37	chr10	98823297	98823297	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagcactgggtgaagagcccGatggttggccgctgcctcag	16	11	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:98823297G>A	uc001kmw.2	-	8	960	c.708C>T	c.(706-708)ATC>ATT	p.I236I	SLIT1_uc009xvh.1_Silent_p.I236I	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	236	LRRCT 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGAAGAGCCCGATGGTTGGCC	0.647													0	0	0	0.009535	0	28	21										A	98823297	G	A	98823297	2	1	42	1	0	0	0	0	0	0	0	1	14739	1048	37	1		1	SLIT1	10	98823297	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	60600	98823297	36711450	182	10922										
SH3PXD2A	9644	broad.mit.edu	37	chr10	105372779	105372780	+	Frame_Shift_Ins	INS	-	-	G													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	catggccctcgccttcggctINSggtggagtttccttgtcccc							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:105372779_105372780insG	uc001kxj.1	-	11	1144_1145	c.1004_1005insC	c.(1003-1005)CCAfs	p.P335fs	SH3PXD2A_uc010qqr.1_Frame_Shift_Ins_p.P225fs|SH3PXD2A_uc010qqs.1_Frame_Shift_Ins_p.P170fs|SH3PXD2A_uc010qqt.1_Frame_Shift_Ins_p.P212fs|SH3PXD2A_uc009xxn.1_Frame_Shift_Ins_p.P170fs|SH3PXD2A_uc010qqu.1_Frame_Shift_Ins_p.P278fs	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	363					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CGCCTTCGGCTGGTGGAGTTTC	0.589																		7	463	---	---								G	105372780	-	G	105372779	7	5	42	1	0	1	1	0	0	0	0	0	14256	1567	55	0	2328	0	SH3PXD2A	10	105372779	Frame_Shift_Ins	INS	-	TCGA-DK-A1A6-01A-11D-A13W-08	6549482	105372779	30161968	183	10923										
PNLIPRP3	119548	broad.mit.edu	37	chr10	118236220	118236220	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aatcgatgcagatgttaacgTtggaaacattacaagtgttc	9	6	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:118236220T>C	uc001lcl.3	+	11	1330	c.1229T>C	c.(1228-1230)GTT>GCT	p.V410A		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	410	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		GATGTTAACGTTGGAAACATT	0.358													0	0	0	0.01441	0	59	60										C	118236220	T	C	118236220	3	2	42	1	0	0	0	0	1	0	0	0	12152	1725	60	5	1271	5	PNLIPRP3	10	118236220	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	12863441	118236220	17298527	184	10924										
PNLIPRP3	119548	broad.mit.edu	37	chr10	118236306	118236306	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgggagcagaaatggtgataAatacatctgggaaatatgga	13	3	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:118236306A>C	uc001lcl.3	+	11	1416	c.1315A>C	c.(1315-1317)AAT>CAT	p.N439H		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	439	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AATGGTGATAAATACATCTGG	0.308													0	0	0	0.010771	0	41	46										C	118236306	A	C	118236306	3	2	42	1	0	0	0	0	1	0	0	0	12152	14	1	5	1357	5	PNLIPRP3	10	118236306	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	86	118236306	17298441	185	10925										
MKI67	4288	broad.mit.edu	37	chr10	129903675	129903676	+	Frame_Shift_Ins	INS	-	-	T													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtactttgtctgtgtgtgtgINSgtctgtgtgagctgcttcag							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:129903675_129903676insT	uc001lke.2	-	13	6623_6624	c.6428_6429insA	c.(6427-6429)ACCfs	p.T2143fs	MKI67_uc001lkf.2_Frame_Shift_Ins_p.T1783fs|MKI67_uc009yav.1_Frame_Shift_Ins_p.T1718fs|MKI67_uc009yaw.1_Frame_Shift_Ins_p.T1293fs	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2143	16 X 122 AA approximate repeats.|10.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTGTGTGTGTGGTCTGTGTGAG	0.495																		15	478	---	---								T	129903676	-	T	129903675	7	5	42	1	0	1	1	0	0	0	0	0	9598	1335	47	0	3353	0	MKI67	10	129903675	Frame_Shift_Ins	INS	-	TCGA-DK-A1A6-01A-11D-A13W-08	11667369	129903675	5631072	186	10926										
C11orf35	256329	broad.mit.edu	37	chr11	558000	558000	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctccatctcctggagcgtgcGggtggtctgcagcagccgct	14	14	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:558000G>A	uc001lpx.2	-	5	502	c.439C>T	c.(439-441)CGC>TGC	p.R147C	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	147	Potential.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGAGCGTGCGGGTGGTCTGC	0.672													0	0	0	0.01441	0	60	63										A	558000	G	A	558000	3	1	42	1	0	0	0	0	1	0	0	0	1638	1116	39	2	1505	2	C11orf35	11	558000	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		558000	134448516	187	10927										
OR52N4	390072	broad.mit.edu	37	chr11	5776753	5776753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	actccagctttcttctccttCttttcccaccgctttgggga	6	15	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:5776753C>G	uc001mbu.2	+	1	831	c.783C>G	c.(781-783)TTC>TTG	p.F261L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TCTTCTCCTTCTTTTCCCACC	0.478													0	0	0	0.007291	0	29	72										G	5776753	C	G	5776753	3	3	42	1	0	0	0	0	1	0	0	0	11129	912	32	1	785	1	OR52N4	11	5776753	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	5218753	5776753	129229763	188	10928										
STK33	65975	broad.mit.edu	37	chr11	8457652	8457652	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	taactcaaaaagcttctcttCtgagcttgccaaaaagggtg	8	9	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:8457652C>T	uc001mgi.1	-	9	1901	c.982G>A	c.(982-984)GAA>AAA	p.E328K	STK33_uc001mgj.1_Missense_Mutation_p.E328K|STK33_uc001mgk.1_Missense_Mutation_p.E328K|STK33_uc010rbn.1_Missense_Mutation_p.E287K|STK33_uc001mgl.3_Missense_Mutation_p.E141K|STK33_uc009yfp.2_Missense_Mutation_p.E50K	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	328	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		AGCTTCTCTTCTGAGCTTGCC	0.308													0	0	0	0.008871	0	19	31										T	8457652	C	T	8457652	3	4	42	1	0	0	0	0	1	0	0	0	15299	922	32	1	578	1	STK33	11	8457652	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2680899	8457652	126548864	189	10929										
STK33	65975	broad.mit.edu	37	chr11	8496434	8496434	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcattttgtggattttttatCtaagccactatcagccattt	6	8	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:8496434C>G	uc001mgi.1	-	1	938	c.19G>C	c.(19-21)GAT>CAT	p.D7H	STK33_uc001mgj.1_Missense_Mutation_p.D7H|STK33_uc001mgk.1_Missense_Mutation_p.D7H|STK33_uc010rbn.1_Intron|STK33_uc001mgl.3_Intron|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	7						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GATTTTTTATCTAAGCCACTA	0.393													0	0	0	0.003954	0	24	57										G	8496434	C	G	8496434	3	3	42	1	0	0	0	0	1	0	0	0	15299	913	32	1	1573	1	STK33	11	8496434	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	38782	8496434	126510082	190	10930										
KCNJ11	3767	broad.mit.edu	37	chr11	17409306	17409306	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagaaggagtggatgctggtGacacagggctcagcagtgcc	17	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:17409306G>A	uc001mna.2	-	1	901	c.333C>T	c.(331-333)GTC>GTT	p.V111V	KCNJ11_uc001mnb.3_Silent_p.V24V	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	111						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		GGATGCTGGTGACACAGGGCT	0.622													0	0	0	0.013726	0	32	51										A	17409306	G	A	17409306	2	1	42	1	0	0	0	0	0	0	0	1	8045	1277	45	1		1	KCNJ11	11	17409306	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	8912872	17409306	117597210	191	10931										
QSER1	79832	broad.mit.edu	37	chr11	32997931	32997931	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	taggacaggaggaaattgttCaactttgtatgaaaaatgta	10	3	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:32997931C>T	uc001mty.2	+	13	5386	c.5119C>T	c.(5119-5121)CAA>TAA	p.Q1707*	QSER1_uc001mtz.1_Nonsense_Mutation_p.Q1468*	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1707										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					GGAAATTGTTCAACTTTGTAT	0.318													0	0	0	0.007413	0	19	32										T	32997931	C	T	32997931	4	4	42	1	0	0	0	0	0	1	0	0	12882	827	29	1	5161	1	QSER1	11	32997931	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	15588625	32997931	102008585	192	10932										
ACCS	84680	broad.mit.edu	37	chr11	44089398	44089398	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagaatgattaaatggttctGggattcagctgaggagggct	14	4	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:44089398G>A	uc009yks.1	+	2	365	c.221G>A	c.(220-222)TGG>TAG	p.W74*	ACCS_uc010rfm.1_Intron|ACCS_uc010rfn.1_Nonsense_Mutation_p.W74*|ACCS_uc001mxx.2_Nonsense_Mutation_p.W74*	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	74							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						AAATGGTTCTGGGATTCAGCT	0.537													0	0	0	0.004656	0	28	37										A	44089398	G	A	44089398	4	1	42	1	0	0	0	0	0	1	0	0	133	1357	47	2	223	2	ACCS	11	44089398	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11091467	44089398	90917118	193	10933										
MAPK8IP1	9479	broad.mit.edu	37	chr11	45924153	45924153	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atgtgcgactagaggccactGaggagatctacctgacccca	11	12	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:45924153G>A	uc001nbr.2	+	5	1005	c.835G>A	c.(835-837)GAG>AAG	p.E279K		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	279	JNK-binding domain (JBD).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		AGAGGCCACTGAGGAGATCTA	0.682													0	0	0	0.004289	0	37	70										A	45924153	G	A	45924153	3	1	42	1	0	0	0	0	1	0	0	0	9284	1291	45	1	853	1	MAPK8IP1	11	45924153	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1834755	45924153	89082363	194	10934										
HARBI1	283254	broad.mit.edu	37	chr11	46637415	46637415	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagagcctgaatggaggcttCatcagctggaaagcgaatga	13	8	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:46637415C>T	uc001ncy.2	-	2	621	c.373G>A	c.(373-375)GAA>AAA	p.E125K	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	125						cytoplasm|nucleus	metal ion binding|nuclease activity				0						ATGGAGGCTTCATCAGCTGGA	0.522													0	0	0	0.01441	0	134	230										T	46637415	C	T	46637415	3	4	42	1	0	0	0	0	1	0	0	0	6958	835	29	1	684	1	HARBI1	11	46637415	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	713262	46637415	88369101	195	10935										
P2RX3	5024	broad.mit.edu	37	chr11	57106039	57106039	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcagcatgaactgcatatcCgacttcttcacctatgagac	6	13	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:57106039C>T	uc001nju.2	+	1	91	c.15C>T	c.(13-15)TCC>TCT	p.S5S	SSRP1_uc001njt.2_5'Flank	NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	5	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						ACTGCATATCCGACTTCTTCA	0.542													0	0	0	0.01441	0	129	273										T	57106039	C	T	57106039	2	4	42	1	0	0	0	0	0	0	0	1	11341	639	23	2		2	P2RX3	11	57106039	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	10468624	57106039	77900477	196	10936										
DAGLA	747	broad.mit.edu	37	chr11	61487650	61487650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcccgggatcgtggtgttccGgcggcgctggtctgtgggca	19	11	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:61487650G>A	uc001nsa.2	+	2	134	c.23G>A	c.(22-24)CGG>CAG	p.R8Q		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	8	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GTGGTGTTCCGGCGGCGCTGG	0.632													0	0	0	0.01441	0	52	96										A	61487650	G	A	61487650	3	1	42	1	0	0	0	0	1	0	0	0	4226	1116	39	2	25	2	DAGLA	11	61487650	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	4381611	61487650	73518866	197	10937										
SLC22A12	116085	broad.mit.edu	37	chr11	64360266	64360266	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atcagtggaacctcgtgtgtGactctcatgctctgaagccc	10	12	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:64360266G>C	uc001oam.1	+	2	1165	c.418G>C	c.(418-420)GAC>CAC	p.D140H	SLC22A12_uc009ypr.1_Missense_Mutation_p.D140H|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.D140H|SLC22A12_uc001oan.1_Missense_Mutation_p.D140H|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	140					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CCTCGTGTGTGACTCTCATGC	0.642													0	0	0	0.01441	0	96	397										C	64360266	G	C	64360266	3	2	42	1	0	0	0	0	1	0	0	0	14443	1290	45	1	424	1	SLC22A12	11	64360266	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2872616	64360266	70646250	198	10938										
CD248	57124	broad.mit.edu	37	chr11	66083610	66083610	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgctggccggaaacccaggcGacagtggcagctgtagcctt	14	13	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:66083610G>A	uc001ohm.1	-	1	906	c.889C>T	c.(889-891)CGC>TGC	p.R297C		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	297	Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	AAACCCAGGCGACAGTGGCAG	0.647													0	0	0	0.01441	0	61	62										A	66083610	G	A	66083610	3	1	42	1	0	0	0	0	1	0	0	0	2989	1058	37	1	1388	1	CD248	11	66083610	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1723344	66083610	68922906	199	10939										
RBM14	10432	broad.mit.edu	37	chr11	66392969	66392969	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccaggctgctgcctcctaccGcggccagccaggcaatgcct	11	18	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:66392969G>A	uc001oit.2	+	2	1761	c.1622G>A	c.(1621-1623)CGC>CAC	p.R541H	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	541	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GCCTCCTACCGCGGCCAGCCA	0.657													0	0	0	0.006122	0	14	110										A	66392969	G	A	66392969	3	1	42	1	0	0	0	0	1	0	0	0	13115	1087	38	2	1628	2	RBM14	11	66392969	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	309359	66392969	68613547	200	10940										
RBM4	5936	broad.mit.edu	37	chr11	66407491	66407491	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagtttgaggagtatggtccGgtcatcgaatgtgacatcgt	13	6	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:66407491G>A	uc009yrj.2	+	2	797	c.309G>A	c.(307-309)CCG>CCA	p.P103P	RBM4_uc009yrk.2_Intron|RBM4_uc001oiv.2_Silent_p.P103P|RBM4_uc001oiw.1_Silent_p.P103P|RBM4_uc001oix.1_Silent_p.P103P|RBM4_uc010rpj.1_Silent_p.P103P|RBM4_uc001oiy.1_Silent_p.P103P|RBM4_uc001oiz.1_Silent_p.P103P	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	103	RRM 2.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		AGTATGGTCCGGTCATCGAAT	0.498													0	0	0	0.01441	0	187	118										A	66407491	G	A	66407491	2	1	42	1	0	0	0	0	0	0	0	1	13134	1103	39	2		2	RBM4	11	66407491	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	14522	66407491	68599025	201	10941										
SUV420H1	51111	broad.mit.edu	37	chr11	67934619	67934619	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caggcgcaggcagtcccactCtggatttaaaagcaccagtg	11	12	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:67934619C>G	uc001onm.1	-	10	1260	c.1004G>C	c.(1003-1005)AGA>ACA	p.R335T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.R163T|SUV420H1_uc009ysf.2_Missense_Mutation_p.R95T|SUV420H1_uc001ono.1_Missense_Mutation_p.R335T|SUV420H1_uc001onp.2_Missense_Mutation_p.R335T|SUV420H1_uc010rqa.1_Missense_Mutation_p.R312T|SUV420H1_uc001onq.2_Missense_Mutation_p.R335T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CAGTCCCACTCTGGATTTAAA	0.408													0	0	0	0.006214	0	9	76										G	67934619	C	G	67934619	3	3	42	1	0	0	0	0	1	0	0	0	15411	913	32	1	1669	1	SUV420H1	11	67934619	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1527128	67934619	67071897	202	10942										
MTL5	9633	broad.mit.edu	37	chr11	68480836	68480836	+	Frame_Shift_Del	DEL	T	T	-													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcccaattggcccttcccaaTttttggctggaaagcttctg							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:68480836delT	uc001ooc.2	-	8	1200	c.1060delA	c.(1060-1062)ATTfs	p.I354fs		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	354					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CCCTTCCCAATTTTTGGCTGG	0.473																		8	2935	---	---								-	68480836	T	-	68480836	7	5	42	1	0	1	0	1	0	0	0	0	9936	1493	52	0	478	0	MTL5	11	68480836	Frame_Shift_Del	DEL	T	TCGA-DK-A1A6-01A-11D-A13W-08	546217	68480836	66525680	203	10943										
FGF3	2248	broad.mit.edu	37	chr11	69631101	69631101	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gactcaccgaagcatagagtCgtcccctcttgttcatggcc	9	14	3	1	rs150581924	by1000genomes	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:69631101C>T	uc001oph.2	-	2	802	c.311G>A	c.(310-312)CGA>CAA	p.R104Q		NM_005247	NP_005238	P11487	FGF3_HUMAN	fibroblast growth factor 3 precursor	104					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			AGCATAGAGTCGTCCCCTCTT	0.597													0	0	0	0.01441	0	62	888										T	69631101	C	T	69631101	3	4	42	1	0	0	0	0	1	0	0	0	5853	884	31	1	416	1	FGF3	11	69631101	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1150265	69631101	65375415	204	10944										
USP35	57558	broad.mit.edu	37	chr11	77907438	77907438	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcgctgggcgcgcgcctctaCgtgggcggcgcggaggagct	20	13	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:77907438C>T	uc009yva.1	+	2	393	c.147C>T	c.(145-147)TAC>TAT	p.Y49Y	USP35_uc001oze.2_Intron|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Translation_Start_Site|USP35_uc001ozf.2_5'Flank	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	49					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CGCGCCTCTACGTGGGCGGCG	0.766													0	0	0	0.006214	0	8	57										T	77907438	C	T	77907438	2	4	42	1	0	0	0	0	0	0	0	1	17063	547	19	2		2	USP35	11	77907438	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	8276337	77907438	57099078	205	10945										
MRE11A	4361	broad.mit.edu	37	chr11	94194101	94194101	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atgtgaactgtaagaaattaCcttctctgcggtttgaaagt	9	6	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:94194101C>G	uc001peu.2	-	12	1515	c.1326_splice	c.e12+1	p.K442_splice	MRE11A_uc001pev.2_Splice_Site_p.K442_splice|MRE11A_uc009ywj.2_Splice_Site_p.K445_splice	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1						DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				TAAGAAATTACCTTCTCTGCG	0.318								Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				0	0	0	0.001984	0	7	15										G	94194101	C	G	94194101	5	3	42	1	0	0	0	0	0	0	1	0	9759	521	18	4	835	4	MRE11A	11	94194101	Splice_Site	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	16286663	94194101	40812415	206	10946										
EXPH5	23086	broad.mit.edu	37	chr11	108384189	108384189	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggcttttggcaagaggcagaGagtcaactgaattgctgctg	14	7	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:108384189G>A	uc001pkk.2	-	6	2156	c.2045C>T	c.(2044-2046)TCT>TTT	p.S682F	EXPH5_uc010rvy.1_Missense_Mutation_p.S494F|EXPH5_uc010rvz.1_Missense_Mutation_p.S526F|EXPH5_uc010rwa.1_Missense_Mutation_p.S606F	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	682					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAGAGGCAGAGAGTCAACTGA	0.413													0	0	0	0.013726	0	32	45										A	108384189	G	A	108384189	3	1	42	1	0	0	0	0	1	0	0	0	5322	942	33	1	3928	1	EXPH5	11	108384189	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	14190088	108384189	26622327	207	10947										
TECTA	7007	broad.mit.edu	37	chr11	121008294	121008294	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agtgtgtcacgcggagtgagTgtggctgcaactttgagggg	18	6	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:121008294T>G	uc010rzo.1	+	10	3106	c.3106T>G	c.(3106-3108)TGT>GGT	p.C1036G		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1036	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCGGAGTGAGTGTGGCTGCAA	0.572													0	0	0	0.008871	0	17	32										G	121008294	T	G	121008294	3	3	42	1	0	0	0	0	1	0	0	0	15744	1696	59	5	3144	5	TECTA	11	121008294	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	12624105	121008294	13998222	208	10948										
EFCAB4B	84766	broad.mit.edu	37	chr12	3806003	3806003	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggtctgaaagaactcctgtgCcttcctcagcatgactagct	9	12	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:3806003C>A	uc001qmj.2	-	4	735	c.163G>T	c.(163-165)GCA>TCA	p.A55S	EFCAB4B_uc010sen.1_Missense_Mutation_p.A55S|EFCAB4B_uc010seo.1_Missense_Mutation_p.A55S	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	55	EF-hand 1.				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			AACTCCTGTGCCTTCCTCAGC	0.597													1	0	0.000175454	0.010504	0.000177404	18	82										A	3806003	C	A	3806003	3	1	42	1	0	0	0	0	1	0	0	0	4937	739	26	4	2292	4	EFCAB4B	12	3806003	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		3806003	130045892	209	10949										
ANO2	57101	broad.mit.edu	37	chr12	5848494	5848494	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agaactcacttcttcctcttCtatgccagtcaggtcccaaa	5	14	5	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:5848494C>T	uc001qnm.2	-	13	1483	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	476	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TCTTCCTCTTCTATGCCAGTC	0.433													0	0	0	0.004672	0	3	13										T	5848494	C	T	5848494	3	4	42	1	0	0	0	0	1	0	0	0	697	922	32	1	1641	1	ANO2	12	5848494	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2042491	5848494	128003401	210	10950										
A2ML1	144568	broad.mit.edu	37	chr12	9004565	9004565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agtccgtggggaatcctttcGtcttactgccaccatcttca	8	13	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:9004565G>A	uc001quz.3	+	19	2518	c.2420G>A	c.(2419-2421)CGT>CAT	p.R807H	A2ML1_uc001qva.1_Missense_Mutation_p.R387H|A2ML1_uc010sgm.1_Missense_Mutation_p.R307H	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	651						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GAATCCTTTCGTCTTACTGCC	0.507													0	0	0	0.007835	0	41	173										A	9004565	G	A	9004565	3	1	42	1	0	0	0	0	1	0	0	0	5	1145	40	2	2494	2	A2ML1	12	9004565	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	3156071	9004565	124847330	211	10951										
ETV6	2120	broad.mit.edu	37	chr12	12022825	12022825	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcaacctctctcatcgggaaGacctggcttacatgaaccac	7	14	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:12022825G>A	uc001qzz.2	+	5	1205	c.931G>A	c.(931-933)GAC>AAC	p.D311N	ETV6_uc001raa.1_Missense_Mutation_p.D104N	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	311						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				TCATCGGGAAGACCTGGCTTA	0.582			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								0	0	0	0.01441	0	81	116										A	12022825	G	A	12022825	3	1	42	1	0	0	0	0	1	0	0	0	5283	942	33	1	949	1	ETV6	12	12022825	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	3018260	12022825	121829070	212	10952										
ETV6	2120	broad.mit.edu	37	chr12	12022873	12022873	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctctgtctccccgcctgaaGagcacgccatgcccattggg	10	16	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:12022873G>C	uc001qzz.2	+	5	1253	c.979G>C	c.(979-981)GAG>CAG	p.E327Q	ETV6_uc001raa.1_Missense_Mutation_p.E120Q	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	327						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCCGCCTGAAGAGCACGCCAT	0.582			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								0	0	0	0.01441	0	68	86										C	12022873	G	C	12022873	3	2	42	1	0	0	0	0	1	0	0	0	5283	943	33	1	997	1	ETV6	12	12022873	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	48	12022873	121829022	213	10953										
LOH12CR1	118426	broad.mit.edu	37	chr12	12514236	12514236	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gaacgtcagcaacgatcccgAtgtcatcaagttgcaagaga	10	10	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:12514236A>T	uc001ral.2	+	2	521	c.155A>T	c.(154-156)GAT>GTT	p.D52V	LOH12CR1_uc009zhu.2_Intron	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	LOH1CR12	52										ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		AACGATCCCGATGTCATCAAG	0.488													0	0	0	0.012213	0	35	230										T	12514236	A	T	12514236	3	4	42	1	0	0	0	0	1	0	0	0	8891	333	12	5	161	5	LOH12CR1	12	12514236	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	491363	12514236	121337659	214	10954										
GALNT6	11226	broad.mit.edu	37	chr12	51757940	51757940	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcatccttgcgcctctgcttCtcatgtggaggaagtgtttc	10	11	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:51757940C>T	uc001ryk.2	-	5	1239	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.E338E	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	338	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GCCTCTGCTTCTCATGTGGAG	0.587													0	0	0	0.01441	0	64	105										T	51757940	C	T	51757940	2	4	42	1	0	0	0	0	0	0	0	1	6217	912	32	1		1	GALNT6	12	51757940	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	39243704	51757940	82093955	215	10955										
OR6C6	283365	broad.mit.edu	37	chr12	55688992	55688992	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caatcctaggagaatgaactCtatttccattgatttgttct	6	8	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:55688992C>G	uc010sph.1	-	1	25	c.25G>C	c.(25-27)GAG>CAG	p.E9Q		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AGAATGAACTCTATTTCCATT	0.318													0	0	0	0.014323	0	19	46										G	55688992	C	G	55688992	3	3	42	1	0	0	0	0	1	0	0	0	11194	922	32	1	921	1	OR6C6	12	55688992	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3931052	55688992	78162903	216	10956										
MBD6	114785	broad.mit.edu	37	chr12	57921371	57921371	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgacccgggggcctcctctCtgggcaaggccccctccaac	11	19	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:57921371C>G	uc001soj.1	+	8	2388	c.2164C>G	c.(2164-2166)CTG>GTG	p.L722V	MBD6_uc001sok.1_Missense_Mutation_p.L589V|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	722	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						GGCCTCCTCTCTGGGCAAGGC	0.597													0	0	0	0.01441	0	218	346										G	57921371	C	G	57921371	3	3	42	1	0	0	0	0	1	0	0	0	9348	912	32	1	2186	1	MBD6	12	57921371	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2232379	57921371	75930524	217	10957										
MON2	23041	broad.mit.edu	37	chr12	62929388	62929388	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagactgggccttgtaacttCaagagatgcctttataactg	9	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:62929388C>T	uc001sre.2	+	14	2190	c.1799C>T	c.(1798-1800)TCA>TTA	p.S600L	MON2_uc009zqj.2_Missense_Mutation_p.S600L|MON2_uc010ssl.1_Missense_Mutation_p.S528L|MON2_uc010ssm.1_Missense_Mutation_p.S600L|MON2_uc010ssn.1_Missense_Mutation_p.S600L|MON2_uc001srf.2_Missense_Mutation_p.S363L	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	600					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CTTGTAACTTCAAGAGATGCC	0.413													0	0	0	0.01441	0	55	63										T	62929388	C	T	62929388	3	4	42	1	0	0	0	0	1	0	0	0	9700	838	29	1	1853	1	MON2	12	62929388	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	5008017	62929388	70922507	218	10958										
LRRIQ1	84125	broad.mit.edu	37	chr12	85438589	85438590	+	Splice_Site	DEL	TA	TA	-													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcagagcaattaattaaggTatatattcaatatttgactt							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:85438589_85438590delTA	uc001tac.2	+	4	447	c.336_splice	c.e4+2	p.K112_splice	LRRIQ1_uc001tab.1_Splice_Site_p.K112_splice|LRRIQ1_uc001taa.1_Splice_Site_p.K112_splice|LRRIQ1_uc001tad.2_Splice_Site_p.K20_splice	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1											ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTAATTAAGGTATATATTCAAT	0.272																		29	35	---	---								-	85438590	TA	-	85438589	8	5	42	1	0	1	0	1	0	0	1	0	9029	1652	57	0	348	0	LRRIQ1	12	85438589	Splice_Site	DEL	TA	TCGA-DK-A1A6-01A-11D-A13W-08	22509201	85438589	48413306	219	10959										
EEA1	8411	broad.mit.edu	37	chr12	93258690	93258690	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgagtcattaccagcatcaTgaacagcttcataatgtttg	7	9	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:93258690T>C	uc001tck.2	-	3	456	c.191A>G	c.(190-192)CAT>CGT	p.H64R		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	64	C2H2-type.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						ACCAGCATCATGAACAGCTTC	0.378													0	0	0	0.010818	0	33	61										C	93258690	T	C	93258690	3	2	42	1	0	0	0	0	1	0	0	0	4921	1464	51	5	4152	5	EEA1	12	93258690	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	7820101	93258690	40593205	220	10960										
C12orf63	374467	broad.mit.edu	37	chr12	97051735	97051735	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atgacaacggtggttctagtCttacctttgagcatcctttg	9	9	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:97051735C>G	uc001tet.1	+	4	529	c.451C>G	c.(451-453)CTT>GTT	p.L151V		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	151										skin(6)|ovary(1)	7						TGGTTCTAGTCTTACCTTTGA	0.353													0	0	0	0.007835	0	38	145										G	97051735	C	G	97051735	3	3	42	1	0	0	0	0	1	0	0	0	1706	913	32	1	461	1	C12orf63	12	97051735	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3793045	97051735	36800160	221	10961										
C12orf63	374467	broad.mit.edu	37	chr12	97051869	97051869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtatctcttgccattcagttCaatacagtttcacagtaagt	6	9	4	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:97051869C>T	uc001tet.1	+	4	663	c.585C>T	c.(583-585)TTC>TTT	p.F195F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	195										skin(6)|ovary(1)	7						CCATTCAGTTCAATACAGTTT	0.303													0	0	0	0.010729	0	10	50										T	97051869	C	T	97051869	2	4	42	1	0	0	0	0	0	0	0	1	1706	825	29	1		1	C12orf63	12	97051869	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	134	97051869	36800026	222	10962										
PAH	5053	broad.mit.edu	37	chr12	103288533	103288533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgtgtctttcttcttatctCgtgaaagctcatggacagtg	9	9	5	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:103288533C>T	uc001tjq.1	-	4	804	c.332G>A	c.(331-333)CGA>CAA	p.R111Q	PAH_uc010swc.1_Missense_Mutation_p.R111Q	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	111					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CTTCTTATCTCGTGAAAGCTC	0.383													0	0	0	0.006122	0	18	67										T	103288533	C	T	103288533	3	4	42	1	0	0	0	0	1	0	0	0	11394	884	31	1	1070	1	PAH	12	103288533	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	6236664	103288533	30563362	223	10963										
PRDM4	11108	broad.mit.edu	37	chr12	108147715	108147715	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acttaccaggtagaatggttCtgaaataactgctctccagg	9	9	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:108147715C>G	uc001tmp.2	-	4	754	c.317G>C	c.(316-318)AGA>ACA	p.R106T	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	106					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TAGAATGGTTCTGAAATAACT	0.433													0	0	0	0.011902	0	42	68										G	108147715	C	G	108147715	3	3	42	1	0	0	0	0	1	0	0	0	12459	913	32	1	2124	1	PRDM4	12	108147715	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4859182	108147715	25704180	224	10964										
ACAD10	80724	broad.mit.edu	37	chr12	112182844	112182844	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tccccactgatcgaagacctCaaggtaaagcagccatggtg	10	12	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:112182844C>T	uc001tsq.2	+	13	2312	c.2112C>T	c.(2110-2112)CTC>CTT	p.L704L	ACAD10_uc001tsp.2_Silent_p.L704L|ACAD10_uc009zvx.2_Silent_p.L735L|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	704							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TCGAAGACCTCAAGGTAAAGC	0.592													0	0	0	0.00632	0	29	84										T	112182844	C	T	112182844	2	4	42	1	0	0	0	0	0	0	0	1	108	813	29	1		1	ACAD10	12	112182844	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4035129	112182844	21669051	225	10965										
C12orf51	283450	broad.mit.edu	37	chr12	112681690	112681690	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccatttacctctgatttgctCtagtaaattccaaatcttca	3	11	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:112681690C>T	uc009zwc.2	-	23	3389	c.3371G>A	c.(3370-3372)AGA>AAA	p.R1124K		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTGATTTGCTCTAGTAAATTC	0.458													0	0	0	0.01441	0	47	171										T	112681690	C	T	112681690	3	4	42	1	0	0	0	0	1	0	0	0	1696	913	32	1	8807	1	C12orf51	12	112681690	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	498846	112681690	21170205	226	10966										
C12orf51	283450	broad.mit.edu	37	chr12	112685315	112685315	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	attcccatcaaaggagacttCcttcattgaacataaaagtt	5	9	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:112685315C>T	uc009zwc.2	-	21	3040	c.3022G>A	c.(3022-3024)GAA>AAA	p.E1008K		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						AAGGAGACTTCCTTCATTGAA	0.318													0	0	0	0.001168	0	4	7										T	112685315	C	T	112685315	3	4	42	1	0	0	0	0	1	0	0	0	1696	864	30	1	9164	1	C12orf51	12	112685315	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3625	112685315	21166580	227	10967										
TPCN1	53373	broad.mit.edu	37	chr12	113705698	113705698	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atggtggtagtgtttgaactCtgcatgaagttacgctggct	13	6	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:113705698C>T	uc001tuw.2	+	5	762	c.465C>T	c.(463-465)CTC>CTT	p.L155L	TPCN1_uc001tux.2_Silent_p.L227L|TPCN1_uc010syt.1_Silent_p.L87L	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	155	Helical; Name=S2 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TGTTTGAACTCTGCATGAAGT	0.607													0	0	0	0.016522	0	23	37										T	113705698	C	T	113705698	2	4	42	1	0	0	0	0	0	0	0	1	16392	900	32	1		1	TPCN1	12	113705698	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1020383	113705698	20146197	228	10968										
UBC	7316	broad.mit.edu	37	chr12	125396365	125396365	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agctgtttcccagcaaagatCaacctctgctgatcaggagg	10	11	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:125396365C>T	uc001ugs.3	-	2	2401	c.1953G>A	c.(1951-1953)TTG>TTA	p.L651L	UBC_uc001ugr.2_RNA|UBC_uc001ugu.1_Silent_p.L575L|UBC_uc001ugt.2_Silent_p.L499L|UBC_uc001ugv.2_Silent_p.L119L	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	651	Ubiquitin-like 9.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CAGCAAAGATCAACCTCTGCT	0.537													0	0	0	0.01441	0	123	477										T	125396365	C	T	125396365	2	4	42	1	0	0	0	0	0	0	0	1	16839	825	29	1		1	UBC	12	125396365	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	11690667	125396365	8455530	229	10969										
DHX37	57647	broad.mit.edu	37	chr12	125461982	125461982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gacgatggggtgctcggccaCagcctccatgattacttgtt	12	11	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:125461982C>T	uc001ugy.2	-	5	892	c.793G>A	c.(793-795)GTG>ATG	p.V265M		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	265	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TGCTCGGCCACAGCCTCCATG	0.552													0	0	0	0.01441	0	148	144										T	125461982	C	T	125461982	3	4	42	1	0	0	0	0	1	0	0	0	4510	478	17	2	2772	2	DHX37	12	125461982	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	65617	125461982	8389913	230	10970										
SFRS8	6433	broad.mit.edu	37	chr12	132203998	132203998	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tttaattttctttttatgcaGaaaaaaatgaggccgaaaat	6	4	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:132203998G>C	uc001uja.1	+	4	661	c.521_splice	c.e4-1	p.E174_splice	SFRS8_uc010tbn.1_Splice_Site_p.E174_splice|SFRS8_uc001ujb.1_Splice_Site|SFRS8_uc001uiz.1_Splice_Site_p.E48_splice	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8						mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		TTTTTATGCAGAAAAAAATGA	0.468													0	0	0	0.01441	0	52	81										C	132203998	G	C	132203998	5	2	42	1	0	0	0	0	0	0	1	0	14183	956	33	1	534	1	SFRS8	12	132203998	Splice_Site	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	6742016	132203998	1647897	231	10971										
EP400	57634	broad.mit.edu	37	chr12	132502160	132502160	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcagcgcatctgcaaccaccCtgggctcgtcgagccccggc	12	18	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:132502160C>T	uc001ujn.2	+	19	4039	c.4004C>T	c.(4003-4005)CCT>CTT	p.P1335L	EP400_uc001ujl.2_Missense_Mutation_p.P1334L|EP400_uc001ujm.2_Missense_Mutation_p.P1335L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1371					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGCAACCACCCTGGGCTCGTC	0.607													0	0	0	0.01441	0	95	141										T	132502160	C	T	132502160	3	4	42	1	0	0	0	0	1	0	0	0	5149	681	24	2	4075	2	EP400	12	132502160	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	298162	132502160	1349735	232	10972										
POLE	5426	broad.mit.edu	37	chr12	133218793	133218793	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acagcctgaactgttgatctCaacagtggcttggtcatcga	10	10	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:133218793C>T	uc001uks.1	-	38	5187	c.5143G>A	c.(5143-5145)GAG>AAG	p.E1715K	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.E519K|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1715					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTGTTGATCTCAACAGTGGCT	0.557								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	96	113										T	133218793	C	T	133218793	3	4	42	1	0	0	0	0	1	0	0	0	12196	835	29	1	1765	1	POLE	12	133218793	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	716633	133218793	633102	233	10973										
POLE	5426	broad.mit.edu	37	chr12	133219161	133219161	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gacggatcatgcgccgggctCcatggcgctgccagtccagg	15	14	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:133219161C>G	uc001uks.1	-	37	4927	c.4883G>C	c.(4882-4884)GGA>GCA	p.G1628A	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.G432A|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1628					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GCGCCGGGCTCCATGGCGCTG	0.582								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	69	86										G	133219161	C	G	133219161	3	3	42	1	0	0	0	0	1	0	0	0	12196	855	30	1	2029	1	POLE	12	133219161	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	368	133219161	632734	234	10974										
FLT1	2321	broad.mit.edu	37	chr13	29008208	29008208	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cacttactttgtcgatgtgtGagatagtttgtcttatacaa	8	6	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:29008208G>C	uc001usb.3	-	5	948	c.663C>G	c.(661-663)CTC>CTG	p.L221L	FLT1_uc010aar.1_Silent_p.L221L|FLT1_uc001usc.3_Silent_p.L221L|FLT1_uc010tdp.1_Silent_p.L221L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	221	Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTCGATGTGTGAGATAGTTTG	0.353													0	0	0	0.006122	0	18	66										C	29008208	G	C	29008208	2	2	42	1	0	0	0	0	0	0	0	1	5941	1277	45	1		1	FLT1	13	29008208	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		29008208	86161670	235	10975										
FREM2	341640	broad.mit.edu	37	chr13	39425843	39425843	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agactgttattaaatttggaGaaaccaaatttagtgtcact	7	5	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:39425843G>A	uc001uwv.2	+	11	7072	c.6763G>A	c.(6763-6765)GAA>AAA	p.E2255K	FREM2_uc001uww.2_Missense_Mutation_p.E341K	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2255	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TAAATTTGGAGAAACCAAATT	0.284													0	0	0	0.007291	0	30	31										A	39425843	G	A	39425843	3	1	42	1	0	0	0	0	1	0	0	0	6045	943	33	1	6805	1	FREM2	13	39425843	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10417635	39425843	75744035	236	10976										
FREM2	341640	broad.mit.edu	37	chr13	39425946	39425946	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcaaaggtttccattgtgaGagtccacaccaaggatggct	10	9	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:39425946G>C	uc001uwv.2	+	11	7175	c.6866G>C	c.(6865-6867)AGA>ACA	p.R2289T	FREM2_uc001uww.2_Missense_Mutation_p.R375T	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2289	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCCATTGTGAGAGTCCACACC	0.512													0	0	0	0.005524	0	36	39										C	39425946	G	C	39425946	3	2	42	1	0	0	0	0	1	0	0	0	6045	942	33	1	6908	1	FREM2	13	39425946	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	103	39425946	75743932	237	10977										
MTRF1	9617	broad.mit.edu	37	chr13	41791298	41791298	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caaaagttcagcaatggcttCttcatctgctgattgaagca	8	9	4	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:41791298C>G	uc001uxx.2	-	12	1761	c.1291G>C	c.(1291-1293)GAA>CAA	p.E431Q	MTRF1_uc001uxy.2_Missense_Mutation_p.E431Q|MTRF1_uc001uxz.2_Missense_Mutation_p.E267Q|MTRF1_uc010tff.1_3'UTR|uc001uxv.1_Intron|uc001uya.1_5'Flank|uc001uyb.2_5'Flank	NM_004294	NP_004285	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	431					regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		GCAATGGCTTCTTCATCTGCT	0.338													0	0	0	0.015359	0	26	71										G	41791298	C	G	41791298	3	3	42	1	0	0	0	0	1	0	0	0	9959	922	32	1	50	1	MTRF1	13	41791298	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2365352	41791298	73378580	238	10978										
OLFM4	10562	broad.mit.edu	37	chr13	53624505	53624505	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	accgcttttcatatgctaatGttgcttggcaagatattgac	8	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:53624505G>A	uc001vhl.2	+	5	1132	c.1132G>A	c.(1132-1134)GTT>ATT	p.V378I	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	378	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		ATATGCTAATGTTGCTTGGCA	0.418													0	0	0	0.01441	0	48	170										A	53624505	G	A	53624505	3	1	42	1	0	0	0	0	1	0	0	0	10855	1377	48	2	1150	2	OLFM4	13	53624505	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11833207	53624505	61545373	239	10979										
IRS2	8660	broad.mit.edu	37	chr13	110435067	110435067	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcgactcccgacacctgctCcatgaggctcagcctcttca	7	18	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:110435067C>A	uc001vqv.2	-	1	3848	c.3334G>T	c.(3334-3336)GAG>TAG	p.E1112*		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1112					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			GACACCTGCTCCATGAGGCTC	0.751													1	0	0.00198382	0.001984	0.00200141	5	26										A	110435067	C	A	110435067	4	1	42	1	0	0	0	0	0	1	0	0	7841	864	30	3	690	3	IRS2	13	110435067	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	56810562	110435067	4734811	240	10980										
LRFN5	145581	broad.mit.edu	37	chr14	42368155	42368155	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atgttgaccagattgtccagGaaacacaggtgagattctta	10	7	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:42368155G>A	uc001wvm.2	+	5	3332	c.2134G>A	c.(2134-2136)GAA>AAA	p.E712K	LRFN5_uc010ana.2_3'UTR	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	712	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GATTGTCCAGGAAACACAGGT	0.279										HNSCC(30;0.082)			0	0	0	0.01441	0	46	36										A	42368155	G	A	42368155	3	1	42	1	0	0	0	0	1	0	0	0	8941	1175	41	1	2144	1	LRFN5	14	42368155	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		42368155	64981385	241	10981										
PTGDR	5729	broad.mit.edu	37	chr14	52735275	52735275	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggactgtgccgagccgcgcgCggacgggagggaagcgtccc	19	13	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:52735275C>T	uc001wzq.2	+	1	845	c.743C>T	c.(742-744)GCG>GTG	p.A248V		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	248	Cytoplasmic (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	GAGCCGCGCGCGGACGGGAGG	0.677													0	0	0	0.01441	0	75	180										T	52735275	C	T	52735275	3	4	42	1	0	0	0	0	1	0	0	0	12741	768	27	2	745	2	PTGDR	14	52735275	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	10367120	52735275	54614265	242	10982										
FERMT2	10979	broad.mit.edu	37	chr14	53342019	53342019	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcaacttcatcaacttctttGtcactgttgttcaaatgatt	4	9	6	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:53342019G>C	uc001xad.2	-	8	1075	c.1020C>G	c.(1018-1020)GAC>GAG	p.D340E	FERMT2_uc001xac.2_Missense_Mutation_p.D340E|FERMT2_uc001xae.2_Missense_Mutation_p.D340E|FERMT2_uc001xaf.2_Missense_Mutation_p.D340E	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	340	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					CAACTTCTTTGTCACTGTTGT	0.333													0	0	0	0.01441	0	50	57										C	53342019	G	C	53342019	3	2	42	1	0	0	0	0	1	0	0	0	5818	1368	48	4	1091	4	FERMT2	14	53342019	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	606744	53342019	54007521	243	10983										
FERMT2	10979	broad.mit.edu	37	chr14	53342072	53342072	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gattgacagcttattgatatGatactgaaaccagaattatt	7	5	0	5			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:53342072G>C	uc001xad.2	-	8	1022	c.967C>G	c.(967-969)CAT>GAT	p.H323D	FERMT2_uc001xac.2_Missense_Mutation_p.H323D|FERMT2_uc001xae.2_Missense_Mutation_p.H323D|FERMT2_uc001xaf.2_Missense_Mutation_p.H323D	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	323	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					TTATTGATATGATACTGAAAC	0.308													0	0	0	0.009535	0	32	52										C	53342072	G	C	53342072	3	2	42	1	0	0	0	0	1	0	0	0	5818	1290	45	1	1144	1	FERMT2	14	53342072	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	53	53342072	54007468	244	10984										
WDHD1	11169	broad.mit.edu	37	chr14	55457948	55457948	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	taccatgaatctgtgagtgaGatgcaacggtgtagaacctg	12	7	1	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:55457948G>C	uc001xbm.1	-	12	1402	c.1324C>G	c.(1324-1326)CTC>GTC	p.L442V	WDHD1_uc010aom.1_Missense_Mutation_p.I20M|WDHD1_uc001xbn.1_Missense_Mutation_p.L319V	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	442						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CTGTGAGTGAGATGCAACGGT	0.388													0	0	0	0.014323	0	20	24										C	55457948	G	C	55457948	3	2	42	1	0	0	0	0	1	0	0	0	17268	942	33	1	2125	1	WDHD1	14	55457948	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2115876	55457948	51891592	245	10985										
COQ6	51004	broad.mit.edu	37	chr14	74428598	74428598	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aggccacaaatgcagtgtctCcactcaaagtaagaggttgc	10	10	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:74428598C>G	uc001xph.2	+	11	1449	c.1369C>G	c.(1369-1371)CCA>GCA	p.P457A	ENTPD5_uc001xpi.2_Intron|COQ6_uc001xpe.2_Missense_Mutation_p.P382A|COQ6_uc001xpf.2_Missense_Mutation_p.P382A|COQ6_uc010tuk.1_Missense_Mutation_p.P432A|COQ6_uc001xpg.2_Intron	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	457					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TGCAGTGTCTCCACTCAAAGT	0.373													0	0	0	0.01441	0	108	107										G	74428598	C	G	74428598	3	3	42	1	0	0	0	0	1	0	0	0	3749	855	30	1	1411	1	COQ6	14	74428598	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	18970650	74428598	32920942	246	10986										
LTBP2	4053	broad.mit.edu	37	chr14	75017934	75017934	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gggcgggggtctggtctccaCgctgttctccactagggcct	15	13	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:75017934C>T	uc001xqa.2	-	7	1906	c.1519G>A	c.(1519-1521)GTG>ATG	p.V507M		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	507					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTGGTCTCCACGCTGTTCTCC	0.682													0	0	0	0.013537	0	13	16										T	75017934	C	T	75017934	3	4	42	1	0	0	0	0	1	0	0	0	9074	536	19	2	4066	2	LTBP2	14	75017934	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	589336	75017934	32331606	247	10987										
C14orf4	64207	broad.mit.edu	37	chr14	77492772	77492772	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	actccaggtacttgaaacccGaggataggccccggccgaag	12	13	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:77492772G>A	uc001xsy.2	-	1	2263	c.1364C>T	c.(1363-1365)TCG>TTG	p.S455L		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	455						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		CTTGAAACCCGAGGATAGGCC	0.612													0	0	0	0.01441	0	57	61										A	77492772	G	A	77492772	3	1	42	1	0	0	0	0	1	0	0	0	1773	1059	37	1	1030	1	C14orf4	14	77492772	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2474838	77492772	29856768	248	10988										
PTPN21	11099	broad.mit.edu	37	chr14	88938710	88938710	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttctgcattttcagggagtcGtgctgttgagcactccccat	10	11	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:88938710G>A	uc001xwv.3	-	15	3080	c.2749C>T	c.(2749-2751)CGA>TGA	p.R917*	PTPN21_uc010twc.1_Nonsense_Mutation_p.R713*	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	917	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TCAGGGAGTCGTGCTGTTGAG	0.393													0	0	0	0.001855	0	12	39										A	88938710	G	A	88938710	4	1	42	1	0	0	0	0	0	1	0	0	12786	1153	40	2	795	2	PTPN21	14	88938710	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11445938	88938710	18410830	249	10989										
BTBD7	55727	broad.mit.edu	37	chr14	93760396	93760396	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtgtaatatcactgttgcatAtttttttggtataatggact	8	4	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:93760396A>G	uc001ybo.2	-	3	1296	c.970T>C	c.(970-972)TAT>CAT	p.Y324H	BTBD7_uc010aur.2_5'UTR|BTBD7_uc010two.1_Missense_Mutation_p.Y239H|BTBD7_uc001ybp.2_Intron|BTBD7_uc001ybq.3_Missense_Mutation_p.Y239H|BTBD7_uc001ybr.2_Missense_Mutation_p.Y324H	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	324	BTB 2.									pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTGTTGCATATTTTTTTGGT	0.418													0	0	0	0.004007	0	17	44										G	93760396	A	G	93760396	3	3	42	1	0	0	0	0	1	0	0	0	1546	449	16	5	2539	5	BTBD7	14	93760396	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	4821686	93760396	13589144	250	10990										
OR4N4	283694	broad.mit.edu	37	chr15	22383192	22383192	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aacaaggccatgtccacgtgCaccactcgtgtcattattat	7	12	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:22383192C>T	uc001yuc.1	+	7	1701	c.720C>T	c.(718-720)TGC>TGT	p.C240C	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Silent_p.C240C	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTCCACGTGCACCACTCGTG	0.493													0	0	0	0.00632	0	26	189										T	22383192	C	T	22383192	2	4	42	1	0	0	0	0	0	0	0	1	11078	718	25	2		2	OR4N4	15	22383192	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		22383192	80148200	251	10991										
IVD	3712	broad.mit.edu	37	chr15	40703469	40703469	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttccttgcagctgatcagtgGtgagtacatcggagccctgg	13	10	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:40703469G>A	uc001zls.3	+	5	810	c.476G>A	c.(475-477)GGT>GAT	p.G159D	IVD_uc001zlq.2_Missense_Mutation_p.G129D	NM_002225	NP_002216	P26440	IVD_HUMAN	isovaleryl Coenzyme A dehydrogenase isoform 1	156					leucine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|isovaleryl-CoA dehydrogenase activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;1.52e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0808)		CTGATCAGTGGTGAGTACATC	0.517													0	0	0	0.01441	0	278	328										A	40703469	G	A	40703469	3	1	42	1	0	0	0	0	1	0	0	0	7928	1261	44	2	494	2	IVD	15	40703469	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	18320277	40703469	61827923	252	10992										
TTBK2	146057	broad.mit.edu	37	chr15	43044889	43044889	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgtctctggaagaaatttctGaagttccaactgtcagaagc	9	8	3	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:43044889G>A	uc001zqo.2	-	14	2994	c.2555C>T	c.(2554-2556)TCA>TTA	p.S852L	TTBK2_uc010bcy.2_Missense_Mutation_p.S783L	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	852					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGAAATTTCTGAAGTTCCAAC	0.373													0	0	0	0.01441	0	56	64										A	43044889	G	A	43044889	3	1	42	1	0	0	0	0	1	0	0	0	16674	1294	45	1	1187	1	TTBK2	15	43044889	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2341420	43044889	59486503	253	10993										
MYO5A	4644	broad.mit.edu	37	chr15	52672022	52672022	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaaaatgccaggctcaccgtGaggggaaaccggccgcactg	13	12	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:52672022G>C	uc002aby.2	-	17	2340	c.2096C>G	c.(2095-2097)TCA>TGA	p.S699*	MYO5A_uc002abx.3_Nonsense_Mutation_p.S699*|MYO5A_uc010uge.1_Nonsense_Mutation_p.S568*	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	699	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GGCTCACCGTGAGGGGAAACC	0.448													0	0	0	0.005443	0	25	122										C	52672022	G	C	52672022	4	2	42	1	0	0	0	0	0	1	0	0	10078	1294	45	1	3571	1	MYO5A	15	52672022	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	9627133	52672022	49859370	254	10994										
LIPC	3990	broad.mit.edu	37	chr15	58834842	58834842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tggaacgcacaagattgggaGaatcacaggtaaccatgcct	11	9	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:58834842G>A	uc010bga.1	+	6	1174	c.566G>A	c.(565-567)AGA>AAA	p.R189K	LIPC_uc010bfz.1_Missense_Mutation_p.R189K|LIPC_uc002afa.1_Missense_Mutation_p.R189K|LIPC_uc010bgb.1_Missense_Mutation_p.R87K|LIPC_uc010ugy.1_Missense_Mutation_p.R128K	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	189	Heparin-binding (Potential).				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		AAGATTGGGAGAATCACAGGT	0.498													0	0	0	0.004289	0	37	111										A	58834842	G	A	58834842	3	1	42	1	0	0	0	0	1	0	0	0	8820	942	33	1	580	1	LIPC	15	58834842	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	6162820	58834842	43696550	255	10995										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84611709	84611709	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gaagagtcacctgtcggcagCtgctaacggatggcagcttt	13	10	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:84611709C>T	uc002bjz.3	+	19	2589	c.2365C>T	c.(2365-2367)CTG>TTG	p.L789L	ADAMTSL3_uc010bmt.1_Silent_p.L789L|ADAMTSL3_uc010bmu.1_Silent_p.L789L	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	789	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGTCGGCAGCTGCTAACGGA	0.547													0	0	0	0.004482	0	9	43										T	84611709	C	T	84611709	2	4	42	1	0	0	0	0	0	0	0	1	276	796	28	2		2	ADAMTSL3	15	84611709	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	25776867	84611709	17919683	256	10996										
AGBL1	123624	broad.mit.edu	37	chr15	86940646	86940646	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgagttcatccaggagagagCaatgccagttgggtgatgaa	14	7	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:86940646C>A	uc002blz.1	+	17	2366	c.2286C>A	c.(2284-2286)AGC>AGA	p.S762R		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	762					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CAGGAGAGAGCAATGCCAGTT	0.453													1	0	4.93089e-13	0.00245	5.18142e-13	14	39										A	86940646	C	A	86940646	3	1	42	1	0	0	0	0	1	0	0	0	375	709	25	4	2348	4	AGBL1	15	86940646	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2328937	86940646	15590746	257	10997										
NTRK3	4916	broad.mit.edu	37	chr15	88678348	88678348	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcacctggaaagggctccttGaggaagtggccattgatggt	14	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:88678348G>A	uc002bme.1	-	9	1350	c.1188C>T	c.(1186-1188)CTC>CTT	p.L396L	NTRK3_uc002bmh.2_Silent_p.L396L|NTRK3_uc002bmf.1_Silent_p.L396L|NTRK3_uc010upl.1_Silent_p.L298L|NTRK3_uc010bnh.1_Silent_p.L396L|NTRK3_uc002bmg.2_Silent_p.L396L	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	396	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGGGCTCCTTGAGGAAGTGGC	0.527			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.010818	0	30	101										A	88678348	G	A	88678348	2	1	42	1	0	0	0	0	0	0	0	1	10708	1277	45	1		1	NTRK3	15	88678348	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1737702	88678348	13853044	258	10998										
MEF2A	4205	broad.mit.edu	37	chr15	100230446	100230446	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aatgatatttttccccccagGgaatggatttgtaaactcaa	7	8	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:100230446G>A	uc010urw.1	+	7	1036	c.677G>A	c.(676-678)GGG>GAG	p.G226E	MEF2A_uc010urv.1_Missense_Mutation_p.G156E|MEF2A_uc010bos.2_Missense_Mutation_p.G224E|MEF2A_uc002bvf.2_Missense_Mutation_p.G226E|MEF2A_uc002bve.2_Missense_Mutation_p.G224E|MEF2A_uc002bvg.2_Missense_Mutation_p.G224E|MEF2A_uc002bvi.2_Missense_Mutation_p.G224E|MEF2A_uc010bot.2_Missense_Mutation_p.G156E	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	226					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TTCCCCCCAGGGAATGGATTT	0.383													0	0	0	0.009096	0	4	22										A	100230446	G	A	100230446	3	1	42	1	0	0	0	0	1	0	0	0	9455	1246	43	2	835	2	MEF2A	15	100230446	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11552098	100230446	2300946	259	10999										
HCFC1R1	54985	broad.mit.edu	37	chr16	3073334	3073334	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtgggtggccatgttctcctCagacagaaactgcttgcgca	12	11	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:3073334C>G	uc002csx.1	-	4	314	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	HCFC1R1_uc002csy.1_Missense_Mutation_p.E61Q|HCFC1R1_uc002csz.1_Missense_Mutation_p.E42Q|THOC6_uc002ctb.2_5'Flank|THOC6_uc002ctd.2_5'Flank|THOC6_uc002ctc.2_5'Flank|THOC6_uc002cta.2_5'Flank	NM_001002018	NP_001002018	Q9NWW0	HPIP_HUMAN	host cell factor C1 regulator 1 (XPO1 dependant)	61						cytoplasm|nucleus					0						ATGTTCTCCTCAGACAGAAAC	0.617													0	0	0	0.01441	0	94	267										G	3073334	C	G	3073334	3	3	42	1	0	0	0	0	1	0	0	0	6992	835	29	1	243	1	HCFC1R1	16	3073334	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		3073334	87281419	260	11000										
ZNF75A	7627	broad.mit.edu	37	chr16	3367835	3367835	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagaaacttcagcaggcggtCaagccttcttagacaccaga	10	11	3	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:3367835C>T	uc002cut.3	+	6	1383	c.857C>T	c.(856-858)TCA>TTA	p.S286L	ZNF75A_uc002cuv.3_RNA	NM_153028	NP_694573	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	286	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						AGCAGGCGGTCAAGCCTTCTT	0.453													0	0	0	0.01441	0	59	42										T	3367835	C	T	3367835	3	4	42	1	0	0	0	0	1	0	0	0	18130	838	29	1	867	1	ZNF75A	16	3367835	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	294501	3367835	86986918	261	11001										
ZNF500	26048	broad.mit.edu	37	chr16	4802759	4802759	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccttcccacagactaggcacTtgtaaggccgctcgcccgtg	10	16	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:4802759T>C	uc002cxp.1	-	6	1308	c.1061A>G	c.(1060-1062)AAG>AGG	p.K354R	ZNF500_uc002cxo.1_Missense_Mutation_p.K146R|ZNF500_uc010uxt.1_Missense_Mutation_p.K354R	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	354	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GACTAGGCACTTGTAAGGCCG	0.622													0	0	0	0.01441	0	111	117										C	4802759	T	C	4802759	3	2	42	1	0	0	0	0	1	0	0	0	17945	1609	56	5	385	5	ZNF500	16	4802759	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	1434924	4802759	85551994	262	11002										
ITPRIPL2	162073	broad.mit.edu	37	chr16	19125972	19125972	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcctcctcagctatgtcctCctgcgctgtcgccacgctgt	8	18	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:19125972C>A	uc002dfu.3	+	1	719	c.189C>A	c.(187-189)CTC>CTA	p.L63L	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	63	Helical; (Potential).					integral to membrane				skin(2)	2						GCTATGTCCTCCTGCGCTGTC	0.721													1	0	0.00448238	0.004482	0.00451213	8	55										A	19125972	C	A	19125972	2	1	42	1	0	0	0	0	0	0	0	1	7925	842	30	3		3	ITPRIPL2	16	19125972	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	14323213	19125972	71228781	263	11003										
RABEP2	79874	broad.mit.edu	37	chr16	28925598	28925598	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgagtgtctgggacgagctGgtagccaggagggggcaggt	20	7	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:28925598G>A	uc002drq.2	-	5	901	c.853C>T	c.(853-855)CAG>TAG	p.Q285*	uc010vct.1_Intron|RABEP2_uc010vdf.1_Nonsense_Mutation_p.Q214*|RABEP2_uc010byn.2_Nonsense_Mutation_p.Q285*|RABEP2_uc002drr.2_Nonsense_Mutation_p.Q285*	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	285					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						GGGACGAGCTGGTAGCCAGGA	0.652													0	0	0	0.004656	0	26	82										A	28925598	G	A	28925598	4	1	42	1	0	0	0	0	0	1	0	0	12962	1357	47	2	892	2	RABEP2	16	28925598	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	9799626	28925598	61429155	264	11004										
HIRIP3	8479	broad.mit.edu	37	chr16	30004529	30004529	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctcctgggggtggcagagctCagttactctcgccatcactg	12	13	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:30004529C>T	uc002dve.2	-	7	2131	c.1670G>A	c.(1669-1671)TGA>TAA	p.*557*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|HIRIP3_uc002dvf.2_3'UTR	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	557					chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						TGGCAGAGCTCAGTTACTCTC	0.567													0	0	0	0.01441	0	69	58										T	30004529	C	T	30004529	2	4	42	1	0	0	0	0	0	0	0	1	7121	837	29	1		1	HIRIP3	16	30004529	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1078931	30004529	60350224	265	11005										
MT1H	4496	broad.mit.edu	37	chr16	56703818	56703818	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tggaccccaactgctcctgcGaggctggtaaggaacgcccg	13	14	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:56703818G>A	uc002ejw.2	+	1	93	c.22G>A	c.(22-24)GAG>AAG	p.E8K	MT1G_uc002eju.1_5'Flank|MT1G_uc002ejv.1_5'Flank	NM_005951	NP_005942	P80294	MT1H_HUMAN	metallothionein 1H	8	Beta.						metal ion binding|protein binding				0						CTGCTCCTGCGAGGCTGGTAA	0.567													0	0	0	0.01441	0	69	277										A	56703818	G	A	56703818	3	1	42	1	0	0	0	0	1	0	0	0	9902	1059	37	1	24	1	MT1H	16	56703818	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	26699289	56703818	33650935	266	11006										
NDRG4	65009	broad.mit.edu	37	chr16	58538305	58538305	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagctggctgccatgctcccCagcgtggtgcagcatttcgg	13	14	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:58538305C>G	uc002eno.2	+	4	397	c.291C>G	c.(289-291)CCC>CCG	p.P97P	NDRG4_uc002enk.2_Silent_p.P129P|NDRG4_uc002enm.2_Silent_p.P149P|NDRG4_uc010vif.1_Silent_p.P129P|NDRG4_uc010cdk.2_Silent_p.P115P|NDRG4_uc010vig.1_Silent_p.P127P|NDRG4_uc010vih.1_Silent_p.P42P|NDRG4_uc010vii.1_Silent_p.P115P|NDRG4_uc002enp.2_Silent_p.P97P|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	97					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						CCATGCTCCCCAGCGTGGTGC	0.677													0	0	0	0.01441	0	216	214										G	58538305	C	G	58538305	2	3	42	1	0	0	0	0	0	0	0	1	10254	581	21	4		4	NDRG4	16	58538305	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1834487	58538305	31816448	267	11007										
FAM65A	79567	broad.mit.edu	37	chr16	67574554	67574554	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtagtggaaagcaggtgtggGacagtgaagaaaccatcttt	14	5	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:67574554G>C	uc010vjp.1	+	10	904	c.808G>C	c.(808-810)GAC>CAC	p.D270H	FAM65A_uc010cei.1_Missense_Mutation_p.D92H|FAM65A_uc002eth.2_Missense_Mutation_p.D250H|FAM65A_uc010cej.2_Missense_Mutation_p.D253H|FAM65A_uc002eti.1_Missense_Mutation_p.D213H|FAM65A_uc010vjq.1_Missense_Mutation_p.D264H|FAM65A_uc002etj.1_Missense_Mutation_p.D249H|FAM65A_uc002etk.2_Missense_Mutation_p.D249H	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	254						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GCAGGTGTGGGACAGTGAAGA	0.547													0	0	0	0.01441	0	193	174										C	67574554	G	C	67574554	3	2	42	1	0	0	0	0	1	0	0	0	5599	1174	41	1	782	1	FAM65A	16	67574554	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	9036249	67574554	22780199	268	11008										
ESRP2	80004	broad.mit.edu	37	chr16	68266170	68266170	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccctgcaatctttacaaactCctcccctgtcgctttataca	3	16	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:68266170C>G	uc010cfa.1	-	9	1194	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Missense_Mutation_p.E326Q	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	336	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						TTTACAAACTCCTCCCCTGTC	0.582													0	0	0	0.01441	0	56	70										G	68266170	C	G	68266170	3	3	42	1	0	0	0	0	1	0	0	0	5259	864	30	1	1205	1	ESRP2	16	68266170	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	691616	68266170	22088583	269	11009										
SLC7A6OS	84138	broad.mit.edu	37	chr16	68335260	68335260	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acttgctccacatccgctgtCtgctgctgcctctttcctcc	6	18	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:68335260C>G	uc002evw.1	-	5	867	c.848G>C	c.(847-849)AGA>ACA	p.R283T	SLC7A6_uc002evt.1_3'UTR|SLC7A6_uc002evu.1_3'UTR|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	283					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		CATCCGCTGTCTGCTGCTGCC	0.522													0	0	0	0.01441	0	73	79										G	68335260	C	G	68335260	3	3	42	1	0	0	0	0	1	0	0	0	14702	913	32	1	85	1	SLC7A6OS	16	68335260	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	69090	68335260	22019493	270	11010										
PKD1L2	114780	broad.mit.edu	37	chr16	81241228	81241228	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgaaactctcactggacaccAtcagctgcagggctgtggat	11	11	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:81241228A>T	uc002fgh.1	-	5	773	c.773T>A	c.(772-774)ATG>AAG	p.M258K	PKD1L2_uc002fgj.2_Missense_Mutation_p.M258K	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	258	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACTGGACACCATCAGCTGCAG	0.443													0	0	0	0.01441	0	65	85										T	81241228	A	T	81241228	3	4	42	1	0	0	0	0	1	0	0	0	11965	217	8	5	6831	5	PKD1L2	16	81241228	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	12905968	81241228	9113525	271	11011										
TSR1	55720	broad.mit.edu	37	chr17	2237950	2237950	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcaaggtgcccaccaagttaTtctcttcactaggaacaaaa	6	11	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:2237950T>C	uc002fuj.2	-	5	1754	c.797A>G	c.(796-798)AAT>AGT	p.N266S	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	266					ribosome assembly	nucleolus	protein binding			ovary(1)	1						CACCAAGTTATTCTCTTCACT	0.458													0	0	0	0.01441	0	104	311										C	2237950	T	C	2237950	3	2	42	1	0	0	0	0	1	0	0	0	16661	1493	52	5	1661	5	TSR1	17	2237950	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08		2237950	78957260	272	11012										
TP53	7157	broad.mit.edu	37	chr17	7579315	7579316	+	Frame_Shift_Ins	INS	-	-	C													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cctcagggcaactgaccgtgINScaagtcacagacttggctgt							TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:7579315_7579316insC	uc002gim.2	-	4	565_566	c.371_372insG	c.(370-372)TGCfs	p.C124fs	TP53_uc002gig.1_Frame_Shift_Ins_p.C124fs|TP53_uc002gih.2_Frame_Shift_Ins_p.C124fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.C124fs|TP53_uc010cni.1_Frame_Shift_Ins_p.C124fs|TP53_uc002gij.2_Frame_Shift_Ins_p.C124fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.C85fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.C139fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	124	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> R (in sporadic cancers; somatic mutation).|C -> G (in a sporadic cancer; somatic mutation).|C -> Y (in a sporadic cancer; somatic mutation).|C -> W (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.C124R(4)|p.G59fs*23(3)|p.C124fs*46(2)|p.C124G(1)|p.V73fs*9(1)|p.T123fs*24(1)|p.C124fs*0(1)|p.G105_T125del21(1)|p.Y107fs*44(1)|p.T125fs*24(1)|p.C124S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.C124fs*48(1)|p.C124Y(1)|p.C124fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGACCGTGCAAGTCACAGA	0.545		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)								96	38	---	---								C	7579316	-	C	7579315	7	5	42	1	0	1	1	0	0	0	0	0	16378	1311	46	0	930	0	TP53	17	7579315	Frame_Shift_Ins	INS	-	TCGA-DK-A1A6-01A-11D-A13W-08	5341365	7579315	73615895	273	11013										
ZNF624	57547	broad.mit.edu	37	chr17	16526354	16526354	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggtgaatgccctctcgcagtCagtacatttatatggtttct	9	9	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526354C>T	uc010cpi.1	-	6	1929	c.1846G>A	c.(1846-1848)GAC>AAC	p.D616N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	616	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CTCTCGCAGTCAGTACATTTA	0.383													0	0	0	0.01441	0	161	197										T	16526354	C	T	16526354	3	4	42	1	0	0	0	0	1	0	0	0	18045	826	29	1	755	1	ZNF624	17	16526354	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	8947039	16526354	64668856	274	11014			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526391	16526391	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttctctccagtgtgaattctCtgatgtacagttaagtgtga	9	7	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526391C>G	uc010cpi.1	-	6	1892	c.1809G>C	c.(1807-1809)CAG>CAC	p.Q603H		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	603	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGTGAATTCTCTGATGTACAG	0.378													0	0	0	0.01441	0	149	164										G	16526391	C	G	16526391	3	3	42	1	0	0	0	0	1	0	0	0	18045	912	32	1	792	1	ZNF624	17	16526391	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	37	16526391	64668819	275	11015			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526600	16526600	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ataattaatgaatgctttccCacattcattacatttatagg	4	7	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526600C>T	uc010cpi.1	-	6	1683	c.1600G>A	c.(1600-1602)GGG>AGG	p.G534R		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	534	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AATGCTTTCCCACATTCATTA	0.383													0	0	0	0.01441	0	92	87										T	16526600	C	T	16526600	3	4	42	1	0	0	0	0	1	0	0	0	18045	594	21	2	1001	2	ZNF624	17	16526600	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	209	16526600	64668610	276	11016			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526725	16526725	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtttttccccagtgtgagttCttatatgtacgataaggctt	9	7	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526725C>T	uc010cpi.1	-	6	1558	c.1475G>A	c.(1474-1476)AGA>AAA	p.R492K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	492	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AGTGTGAGTTCTTATATGTAC	0.383													0	0	0	0.01441	0	81	92										T	16526725	C	T	16526725	3	4	42	1	0	0	0	0	1	0	0	0	18045	913	32	1	1126	1	ZNF624	17	16526725	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	125	16526725	64668485	277	11017			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526782	16526782	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttttccacattcgttacatCtaaaaggtttctctccagta	4	11	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526782C>G	uc010cpi.1	-	6	1501	c.1418G>C	c.(1417-1419)AGA>ACA	p.R473T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	473	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTCGTTACATCTAAAAGGTTT	0.373													0	0	0	0.01441	0	68	69										G	16526782	C	G	16526782	3	3	42	1	0	0	0	0	1	0	0	0	18045	913	32	1	1183	1	ZNF624	17	16526782	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	57	16526782	64668428	278	11018			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526838	16526838	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acattaaaaattgtggtattCttaaaagacttcccacactc	4	9	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526838C>G	uc010cpi.1	-	6	1445	c.1362G>C	c.(1360-1362)AAG>AAC	p.K454N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	454	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTGTGGTATTCTTAAAAGACT	0.383													0	0	0	0.01441	0	56	67										G	16526838	C	G	16526838	3	3	42	1	0	0	0	0	1	0	0	0	18045	912	32	1	1239	1	ZNF624	17	16526838	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	56	16526838	64668372	279	11019			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526858	16526858	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttaaaagacttcccacactCgttgcactgatatggtttct	6	11	1	2	rs138787716		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526858C>T	uc010cpi.1	-	6	1425	c.1342G>A	c.(1342-1344)GAG>AAG	p.E448K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	448	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTCCCACACTCGTTGCACTGA	0.388													0	0	0	0.01441	0	55	71										T	16526858	C	T	16526858	3	4	42	1	0	0	0	0	1	0	0	0	18045	893	31	1	1259	1	ZNF624	17	16526858	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	20	16526858	64668352	280	11020			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526922	16526922	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acactaagatatgacttgttCctaaaggctttcccacaatc	5	11	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526922C>T	uc010cpi.1	-	6	1361	c.1278G>A	c.(1276-1278)AGG>AGA	p.R426R		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	426	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		ATGACTTGTTCCTAAAGGCTT	0.388													0	0	0	0.01441	0	61	66										T	16526922	C	T	16526922	2	4	42	1	0	0	0	0	0	0	0	1	18045	854	30	1		1	ZNF624	17	16526922	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	64	16526922	64668288	281	11021			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526945	16526945	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaaggctttcccacaatcatCacatttgtagggtttctcac	6	11	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526945C>G	uc010cpi.1	-	6	1338	c.1255G>C	c.(1255-1257)GAT>CAT	p.D419H		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	419	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCACAATCATCACATTTGTAG	0.403													0	0	0	0.01441	0	59	69										G	16526945	C	G	16526945	3	3	42	1	0	0	0	0	1	0	0	0	18045	826	29	1	1346	1	ZNF624	17	16526945	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	23	16526945	64668265	282	11022			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16526963	16526963	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atcacatttgtagggtttctCaccattgtgagtttcctgat	8	8	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526963C>T	uc010cpi.1	-	6	1320	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TAGGGTTTCTCACCATTGTGA	0.388													0	0	0	0.01441	0	58	71										T	16526963	C	T	16526963	3	4	42	1	0	0	0	0	1	0	0	0	18045	835	29	1	1364	1	ZNF624	17	16526963	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	18	16526963	64668247	283	11023			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527313	16527313	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtttttctttagtatgagttCtttgatgttgaatgagcaat	9	3	2	4			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527313C>G	uc010cpi.1	-	6	970	c.887G>C	c.(886-888)AGA>ACA	p.R296T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	296	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AGTATGAGTTCTTTGATGTTG	0.348													0	0	0	0.01441	0	90	65										G	16527313	C	G	16527313	3	3	42	1	0	0	0	0	1	0	0	0	18045	913	32	1	1714	1	ZNF624	17	16527313	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	350	16527313	64667897	284	11024			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527465	16527465	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcatctccttgcaaattatCttccccaaatgggtatctgt	5	11	4	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527465C>G	uc010cpi.1	-	6	818	c.735G>C	c.(733-735)AAG>AAC	p.K245N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGCAAATTATCTTCCCCAAAT	0.383													0	0	0	0.01441	0	100	101										G	16527465	C	G	16527465	3	3	42	1	0	0	0	0	1	0	0	0	18045	912	32	1	1866	1	ZNF624	17	16527465	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	152	16527465	64667745	285	11025			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527501	16527501	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctgtaatcaaatttaaattCtctgtgaaattttcctcttg	4	7	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527501C>G	uc010cpi.1	-	6	782	c.699G>C	c.(697-699)GAG>GAC	p.E233D		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AATTTAAATTCTCTGTGAAAT	0.393													0	0	0	0.01441	0	82	91										G	16527501	C	G	16527501	3	3	42	1	0	0	0	0	1	0	0	0	18045	912	32	1	1902	1	ZNF624	17	16527501	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	36	16527501	64667709	286	11026			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527670	16527670	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctcctgattattttgtaatCtcaatatcctatcattccat	2	10	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527670C>G	uc010cpi.1	-	6	613	c.530G>C	c.(529-531)AGA>ACA	p.R177T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		ATTTTGTAATCTCAATATCCT	0.358													0	0	0	0.01441	0	83	72										G	16527670	C	G	16527670	3	3	42	1	0	0	0	0	1	0	0	0	18045	913	32	1	2071	1	ZNF624	17	16527670	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	169	16527670	64667540	287	11027			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527693	16527693	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aatatcctatcattccatttCcataacccttccattctgga	2	13	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527693C>T	uc010cpi.1	-	6	590	c.507G>A	c.(505-507)TGG>TGA	p.W169*		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CATTCCATTTCCATAACCCTT	0.383													0	0	0	0.01441	0	90	85										T	16527693	C	T	16527693	4	4	42	1	0	0	0	0	0	1	0	0	18045	856	30	1	2094	1	ZNF624	17	16527693	Nonsense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	23	16527693	64667517	288	11028			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527709	16527709	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atttccataacccttccattCtggaatcccacagaccattc	3	15	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527709C>T	uc010cpi.1	-	6	574	c.491G>A	c.(490-492)AGA>AAA	p.R164K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCCTTCCATTCTGGAATCCCA	0.393													0	0	0	0.01441	0	85	97										T	16527709	C	T	16527709	3	4	42	1	0	0	0	0	1	0	0	0	18045	913	32	1	2110	1	ZNF624	17	16527709	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	16	16527709	64667501	289	11029			1	45		17	17	1414	C		1.661243e-42
ZNF624	57547	broad.mit.edu	37	chr17	16527767	16527767	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tatggcctcctgtgataaatCttcagaaatagcctttgttc	7	9	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527767C>T	uc010cpi.1	-	6	516	c.433G>A	c.(433-435)GAT>AAT	p.D145N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGTGATAAATCTTCAGAAATA	0.408													0	0	0	0.01441	0	85	88										T	16527767	C	T	16527767	3	4	42	1	0	0	0	0	1	0	0	0	18045	913	32	1	2168	1	ZNF624	17	16527767	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	58	16527767	64667443	290	11030			1	45		17	17	1414	C		1.661243e-42
MYO15A	51168	broad.mit.edu	37	chr17	18022918	18022918	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcgggcctcggcccctacagCccggcctggccaccctacgg	13	20	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:18022918C>A	uc010vxh.1	+	2	1142	c.804C>A	c.(802-804)AGC>AGA	p.S268R		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	268	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCCCCTACAGCCCGGCCTGGC	0.642													1	0	1.59438e-142	0.01441	1.74806e-142	272	39										A	18022918	C	A	18022918	3	1	42	1	0	0	0	0	1	0	0	0	10063	738	26	4	806	4	MYO15A	17	18022918	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1495151	18022918	63172292	291	11031										
ERBB2	2064	broad.mit.edu	37	chr17	37880261	37880261	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagccaacaaagaaatcttaGacgtaagcccctccaccctc	5	15	1	2	rs121913468		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:37880261G>A	uc002hso.2	+	19	2543	c.2305G>A	c.(2305-2307)GAC>AAC	p.D769N	ERBB2_uc002hsm.2_Missense_Mutation_p.D739N|ERBB2_uc010cwa.2_Missense_Mutation_p.D754N|ERBB2_uc002hsp.2_Missense_Mutation_p.D572N|ERBB2_uc010cwb.2_Missense_Mutation_p.D769N|ERBB2_uc010wek.1_Missense_Mutation_p.D493N	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	769	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D769H(3)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	AGAAATCTTAGACGTAAGCCC	0.532		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.01441	0	256	18										A	37880261	G	A	37880261	3	1	42	1	0	0	0	0	1	0	0	0	5206	942	33	1	2379	1	ERBB2	17	37880261	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	19857343	37880261	43314949	292	11032										
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39261731	39261731	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gctgccgccccagctgctgtGagaccacctgctgcaggacc	12	17	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:39261731G>A	uc010wfp.1	+	1	91	c.91G>A	c.(91-93)GAG>AAG	p.E31K		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	31	2.|29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament					0						CAGCTGCTGTGAGACCACCTG	0.637													0	0	0	0.01441	0	52	19										A	39261731	G	A	39261731	3	1	42	1	0	0	0	0	1	0	0	0	8557	1291	45	1	93	1	KRTAP4-9	17	39261731	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1381470	39261731	41933479	293	11033										
KAT2A	2648	broad.mit.edu	37	chr17	40265828	40265828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttccgggtcacgtagtagcGgcttcgcagccgctcagtca	12	14	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:40265828G>A	uc002hyx.2	-	18	2413	c.2353C>T	c.(2353-2355)CGC>TGC	p.R785C	DHX58_uc002hyv.3_5'Flank|DHX58_uc002hyw.3_5'Flank|DHX58_uc010wgf.1_5'Flank	NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	785	Bromo.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						ACGTAGTAGCGGCTTCGCAGC	0.632													0	0	0	0.008871	0	20	56										A	40265828	G	A	40265828	3	1	42	1	0	0	0	0	1	0	0	0	7981	1116	39	2	164	2	KAT2A	17	40265828	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1004097	40265828	40929382	294	11034										
TLK2	11011	broad.mit.edu	37	chr17	60655841	60655841	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tttccttttcgctttaggagGaagcagagatccaggcagag	12	8	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:60655841G>A	uc010ddp.2	+	15	1526	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	TLK2_uc002izx.3_Missense_Mutation_p.E246K|TLK2_uc002izz.3_Missense_Mutation_p.E398K|TLK2_uc002jaa.3_Missense_Mutation_p.E366K|TLK2_uc010wpd.1_Missense_Mutation_p.E366K	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	420	Potential.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						GCTTTAGGAGGAAGCAGAGAT	0.368													0	0	0	0.008291	0	11	78										A	60655841	G	A	60655841	3	1	42	1	0	0	0	0	1	0	0	0	15941	1175	41	1	1242	1	TLK2	17	60655841	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	20390013	60655841	20539369	295	11035										
CCDC46	201134	broad.mit.edu	37	chr17	64049896	64049896	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tattcactctccattttattCagacgcacatttgtatcctc	3	12	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:64049896C>T	uc002jfl.2	-	12	1395	c.1176G>A	c.(1174-1176)CTG>CTA	p.L392L	CCDC46_uc010deo.2_Silent_p.L134L|CCDC46_uc002jfm.2_Silent_p.L392L|CCDC46_uc010dep.2_Silent_p.L350L	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	392	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			CCATTTTATTCAGACGCACAT	0.388													0	0	0	0.009718	0	41	206										T	64049896	C	T	64049896	2	4	42	1	0	0	0	0	0	0	0	1	2817	813	29	1		1	CCDC46	17	64049896	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3394055	64049896	17145314	296	11036										
NAT9	26151	broad.mit.edu	37	chr17	72767986	72767986	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtcacctcctgaaaaacactGctcgtagccacctacgtgag	8	14	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:72767986G>A	uc002jlq.2	-	7	575	c.501C>T	c.(499-501)AGC>AGT	p.S167S	NAT9_uc002jlr.2_Silent_p.S166S	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9	167	N-acetyltransferase.					protein complex	N-acetyltransferase activity				0						GAAAAACACTGCTCGTAGCCA	0.557													0	0	0	0.01441	0	89	137										A	72767986	G	A	72767986	2	1	42	1	0	0	0	0	0	0	0	1	10182	1310	46	2		2	NAT9	17	72767986	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	8718090	72767986	8427224	297	11037										
FADS6	283985	broad.mit.edu	37	chr17	72888659	72888659	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cccaggctcacctccacaaaGaaaagcagccagatcttgct	7	15	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:72888659G>A	uc002jmd.1	-	2	360	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	122	Helical; (Potential).				fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CCTCCACAAAGAAAAGCAGCC	0.597													0	0	0	0.00874	0	39	52										A	72888659	G	A	72888659	2	1	42	1	0	0	0	0	0	0	0	1	5368	933	33	1		1	FADS6	17	72888659	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	120673	72888659	8306551	298	11038										
TNRC6C	57690	broad.mit.edu	37	chr17	76047083	76047083	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctggggcaacagcacaaataCaaaggccaatccaggtacaa	9	11	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:76047083C>T	uc002jud.2	+	4	2540	c.1940C>T	c.(1939-1941)ACA>ATA	p.T647I	TNRC6C_uc002juf.2_Missense_Mutation_p.T647I|TNRC6C_uc002jue.2_Missense_Mutation_p.T647I	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	647	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCACAAATACAAAGGCCAAT	0.502													0	0	0	0.00632	0	29	36										T	76047083	C	T	76047083	3	4	42	1	0	0	0	0	1	0	0	0	16339	478	17	2	1942	2	TNRC6C	17	76047083	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3158424	76047083	5148127	299	11039										
TBC1D16	125058	broad.mit.edu	37	chr17	77922741	77922741	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccgatctgtccggaccacgtCtttgtccacagtgaactgca	9	14	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:77922741C>T	uc002jxj.2	-	8	1587	c.1471G>A	c.(1471-1473)GAC>AAC	p.D491N	TBC1D16_uc002jxh.2_Missense_Mutation_p.D129N|TBC1D16_uc002jxi.2_Missense_Mutation_p.D116N|TBC1D16_uc002jxk.1_Missense_Mutation_p.D129N	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	491	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			CGGACCACGTCTTTGTCCACA	0.602													0	0	0	0.01441	0	208	331										T	77922741	C	T	77922741	3	4	42	1	0	0	0	0	1	0	0	0	15602	913	32	1	852	1	TBC1D16	17	77922741	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1875658	77922741	3272469	300	11040										
CCDC40	55036	broad.mit.edu	37	chr17	78058702	78058702	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	caacagccagagcgagatctCccggcgcacgatcctgatcg	11	15	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:78058702C>G	uc010dht.2	+	13	2177	c.2150C>G	c.(2149-2151)TCC>TGC	p.S717C	CCDC40_uc002jxm.3_Missense_Mutation_p.S500C|CCDC40_uc002jxn.3_Missense_Mutation_p.S113C	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	717	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGCGAGATCTCCCGGCGCACG	0.602													0	0	0	0.01441	0	63	106										G	78058702	C	G	78058702	3	3	42	1	0	0	0	0	1	0	0	0	2812	855	30	1	2200	1	CCDC40	17	78058702	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	135961	78058702	3136508	301	11041										
CCDC40	55036	broad.mit.edu	37	chr17	78059829	78059829	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagtggggcccctggagcttGaaatcaaaaggctgagcaag	14	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:78059829G>C	uc010dht.2	+	14	2290	c.2263G>C	c.(2263-2265)GAA>CAA	p.E755Q	CCDC40_uc002jxm.3_Missense_Mutation_p.E538Q|CCDC40_uc002jxn.3_Missense_Mutation_p.E151Q	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	755	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CCTGGAGCTTGAAATCAAAAG	0.448													0	0	0	0.01441	0	123	197										C	78059829	G	C	78059829	3	2	42	1	0	0	0	0	1	0	0	0	2812	1291	45	1	2317	1	CCDC40	17	78059829	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1127	78059829	3135381	302	11042										
EMILIN2	84034	broad.mit.edu	37	chr18	2892205	2892205	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttgtaaggaatgcacgcagGgggtccagagggaggtctcc	16	9	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:2892205G>A	uc002kln.2	+	4	2239	c.2080G>A	c.(2080-2082)GGG>AGG	p.G694R		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	694					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		ATGCACGCAGGGGGTCCAGAG	0.562													0	0	0	0.01441	0	112	141										A	2892205	G	A	2892205	3	1	42	1	0	0	0	0	1	0	0	0	5094	1232	43	2	2094	2	EMILIN2	18	2892205	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		2892205	75185043	303	11043										
ROCK1	6093	broad.mit.edu	37	chr18	18622100	18622100	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	taaggttttttgcttcttttGatatgtcattatcatcagga	7	5	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:18622100G>C	uc002kte.2	-	8	1858	c.917C>G	c.(916-918)TCA>TGA	p.S306*		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	306	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TGCTTCTTTTGATATGTCATT	0.333													0	0	0	0.016522	0	22	59										C	18622100	G	C	18622100	4	2	42	1	0	0	0	0	0	1	0	0	13517	1294	45	1	3251	1	ROCK1	18	18622100	Nonsense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	15729895	18622100	59455148	304	11044										
OSBPL1A	114876	broad.mit.edu	37	chr18	21746618	21746618	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gggaatcacactctccatgtCtttgtctacttcattcaaaa	5	11	6	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:21746618C>G	uc002kve.2	-	26	2758	c.2584G>C	c.(2584-2586)GAC>CAC	p.D862H	OSBPL1A_uc002kvd.2_Missense_Mutation_p.D349H|OSBPL1A_uc010xbc.1_Missense_Mutation_p.D480H	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	862					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTCTCCATGTCTTTGTCTACT	0.398													0	0	0	0.01441	0	74	62										G	21746618	C	G	21746618	3	3	42	1	0	0	0	0	1	0	0	0	11277	913	32	1	280	1	OSBPL1A	18	21746618	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3124518	21746618	56330630	305	11045										
ST8SIA3	51046	broad.mit.edu	37	chr18	55024415	55024415	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttgttttccgttgcaatttcGcccctacggaggctttccaa	8	12	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:55024415G>A	uc002lgn.2	+	3	931	c.574G>A	c.(574-576)GCC>ACC	p.A192T		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	192	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TTGCAATTTCGCCCCTACGGA	0.403													0	0	0	0.01441	0	71	56										A	55024415	G	A	55024415	3	1	42	1	0	0	0	0	1	0	0	0	15232	1087	38	2	584	2	ST8SIA3	18	55024415	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	33277797	55024415	23052833	306	11046										
C18orf22	79863	broad.mit.edu	37	chr18	77794621	77794621	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgctctgctgtctcctgcaaGaactggctcaagaaatttgc	9	11	3	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:77794621G>C	uc002lns.2	+	1	264	c.126G>C	c.(124-126)AAG>AAC	p.K42N	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Missense_Mutation_p.K42N|C18orf22_uc010dri.1_RNA	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	42					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		TCTCCTGCAAGAACTGGCTCA	0.657													0	0	0	0.013537	0	13	198										C	77794621	G	C	77794621	3	2	42	1	0	0	0	0	1	0	0	0	1898	933	33	1	128	1	C18orf22	18	77794621	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	22770206	77794621	282627	307	11047										
DOT1L	84444	broad.mit.edu	37	chr19	2222099	2222099	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctgggagcctttttgccacCgtggggtcccgcagctccac	12	15	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:2222099C>T	uc002lvb.3	+	24	2967	c.2931C>T	c.(2929-2931)ACC>ACT	p.T977T	DOT1L_uc002lvc.1_Silent_p.T271T|DOT1L_uc002lve.1_3'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	977						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTTTGCCACCGTGGGGTCCC	0.701													0	0	0	0.01441	0	97	113										T	2222099	C	T	2222099	2	4	42	1	0	0	0	0	0	0	0	1	4709	639	23	2		2	DOT1L	19	2222099	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		2222099	56906884	308	11048										
PLIN3	10226	broad.mit.edu	37	chr19	4859618	4859618	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttaccttctccgtgggctgcTgcaggatggggaggttctcc	14	11	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:4859618T>C	uc002mbj.2	-	4	509	c.332A>G	c.(331-333)CAG>CGG	p.Q111R	PLIN3_uc002mbk.2_Missense_Mutation_p.Q111R|PLIN3_uc002mbl.3_Missense_Mutation_p.Q111R	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	111				ILQ -> MLR (in Ref. 2; AAD11622).	vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	CGTGGGCTGCTGCAGGATGGG	0.572													0	0	0	0.01441	0	76	74										C	4859618	T	C	4859618	3	2	42	1	0	0	0	0	1	0	0	0	12091	1580	55	5	992	5	PLIN3	19	4859618	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	2637519	4859618	54269365	309	11049										
C3	718	broad.mit.edu	37	chr19	6686860	6686860	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtgtaggatctctgtaggttCatgtagttggcttcaaggaa	13	5	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:6686860C>T	uc002mfm.2	-	28	3605	c.3543G>A	c.(3541-3543)ATG>ATA	p.M1181I	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1181					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCTGTAGGTTCATGTAGTTGG	0.517													0	0	0	0.01441	0	114	107										T	6686860	C	T	6686860	3	4	42	1	0	0	0	0	1	0	0	0	2204	826	29	1	1504	1	C3	19	6686860	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1827242	6686860	52442123	310	11050										
DNASE2	1777	broad.mit.edu	37	chr19	12991823	12991823	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggtacagcggctgcaggcttCggcccacggccccctccggg	15	17	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:12991823C>T	uc002mvn.1	-	2	376	c.230G>A	c.(229-231)CGA>CAA	p.R77Q	DNASE2_uc010xmr.1_Missense_Mutation_p.R77Q	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor	77					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						CTGCAGGCTTCGGCCCACGGC	0.677								Direct_reversal_of_damage					0	0	0	0.01441	0	72	73										T	12991823	C	T	12991823	3	4	42	1	0	0	0	0	1	0	0	0	4664	884	31	1	872	1	DNASE2	19	12991823	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	6304963	12991823	46137160	311	11051										
CPAMD8	27151	broad.mit.edu	37	chr19	17039045	17039045	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggctctggaccatggccaacCtggaaaaagaaaccaaggct	11	11	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17039045C>G	uc002nfb.2	-	25	3318	c.3286_splice	c.e25-1	p.V1096_splice		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain							extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CATGGCCAACCTGGAAAAAGA	0.597													0	0	0	0.00245	0	15	61										G	17039045	C	G	17039045	5	3	42	1	0	0	0	0	0	0	1	0	3795	695	24	4	2585	4	CPAMD8	19	17039045	Splice_Site	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4047222	17039045	42089938	312	11052										
HAUS8	93323	broad.mit.edu	37	chr19	17166705	17166705	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ccatctccctccaggtggatGgacctcacgggcagctcgtg	12	15	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17166705G>A	uc002nfe.2	-	9	864	c.753C>T	c.(751-753)TCC>TCT	p.S251S	HAUS8_uc002nff.2_Silent_p.S250S|HAUS8_uc002nfg.1_Silent_p.S190S|HAUS8_uc002nfh.1_Silent_p.S251S	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	251					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						CCAGGTGGATGGACCTCACGG	0.642													0	0	0	0.008361	0	28	88										A	17166705	G	A	17166705	2	1	42	1	0	0	0	0	0	0	0	1	6972	1335	47	2		2	HAUS8	19	17166705	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	127660	17166705	41962278	313	11053										
JAK3	3718	broad.mit.edu	37	chr19	17953857	17953857	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgacagtcttcagcagctctCccggccgctgggcctgctct	11	16	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17953857C>T	uc002nhn.3	-	5	645	c.545G>A	c.(544-546)GGA>GAA	p.G182E	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.G182E|JAK3_uc010xpx.1_Missense_Mutation_p.G182E|JAK3_uc010xpy.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	182	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CAGCAGCTCTCCCGGCCGCTG	0.687		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.01441	0	49	79										T	17953857	C	T	17953857	3	4	42	1	0	0	0	0	1	0	0	0	7939	855	30	1	2909	1	JAK3	19	17953857	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	787152	17953857	41175126	314	11054										
ISYNA1	51477	broad.mit.edu	37	chr19	18546114	18546114	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cagctgcgctggcggaaaagCgcattgaccaccgggctgcc	14	14	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:18546114C>A	uc002njd.1	-	10	1484	c.1434G>T	c.(1432-1434)GCG>GCT	p.A478A	ISYNA1_uc002nja.1_Silent_p.A350A|ISYNA1_uc002njb.1_Silent_p.A396A|ISYNA1_uc002njc.1_Silent_p.A328A|ISYNA1_uc010xqh.1_Silent_p.A276A|ISYNA1_uc002nje.1_Silent_p.A424A|ISYNA1_uc002njf.1_Silent_p.A328A	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	478					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						GGCGGAAAAGCGCATTGACCA	0.662													1	0	7.01153e-11	0.007291	7.31708e-11	27	387										A	18546114	C	A	18546114	2	1	42	1	0	0	0	0	0	0	0	1	7867	755	27	4		4	ISYNA1	19	18546114	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	592257	18546114	40582869	315	11055										
ZNF90	7643	broad.mit.edu	37	chr19	20229706	20229706	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cacacataagataattcataGtggagagaaaccctacaaat	6	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:20229706G>A	uc002nor.2	+	4	1482	c.1343G>A	c.(1342-1344)AGT>AAT	p.S448N	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	448						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ATAATTCATAGTGGAGAGAAA	0.393													0	0	0	0.014758	0	5	34										A	20229706	G	A	20229706	3	1	42	1	0	0	0	0	1	0	0	0	18196	1029	36	2	1357	2	ZNF90	19	20229706	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1683592	20229706	38899277	316	11056										
ZNF99	7652	broad.mit.edu	37	chr19	22940978	22940978	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctttatgtctagtaagatgtGaagattgcttaaaagctttg	9	4	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:22940978G>A	uc010xrh.1	-	5	1460	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGTAAGATGTGAAGATTGCTT	0.358													0	0	0	0.00245	0	15	74										A	22940978	G	A	22940978	3	1	42	1	0	0	0	0	1	0	0	0	18201	1294	45	1	1664	1	ZNF99	19	22940978	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2711272	22940978	36188005	317	11057										
ZNF99	7652	broad.mit.edu	37	chr19	22941120	22941120	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtagggtttctttccagtatGaattatcttatgttttctaa	7	5	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:22941120G>A	uc010xrh.1	-	5	1318	c.1318C>T	c.(1318-1320)CAT>TAT	p.H440Y		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCCAGTATGAATTATCTTA	0.343													0	0	0	0.007835	0	38	44										A	22941120	G	A	22941120	3	1	42	1	0	0	0	0	1	0	0	0	18201	1290	45	1	1806	1	ZNF99	19	22941120	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	142	22941120	36187863	318	11058										
CATSPERG	57828	broad.mit.edu	37	chr19	38860868	38860868	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cacatccacgggctgccactCagtcccaagcgggccctttt	9	17	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:38860868C>T	uc002oih.3	+	28	3270	c.3183C>T	c.(3181-3183)CTC>CTT	p.L1061L	CATSPERG_uc002oig.3_Silent_p.L1021L|CATSPERG_uc002oif.3_Silent_p.L701L|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1061	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						GGCTGCCACTCAGTCCCAAGC	0.602													0	0	0	0.013726	0	33	89										T	38860868	C	T	38860868	2	4	42	1	0	0	0	0	0	0	0	1	2692	813	29	1		1	CATSPERG	19	38860868	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	15919748	38860868	20268115	319	11059										
PSG1	5669	broad.mit.edu	37	chr19	43376148	43376148	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagctcacagcctccatggtCtccctgggatttaagttgct	9	12	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:43376148C>T	uc002ovb.2	-	3	618	c.480G>A	c.(478-480)GAG>GAA	p.E160E	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.E160E|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.E160E|PSG1_uc010eio.1_Silent_p.E160E|PSG1_uc002oux.1_Silent_p.E89E|PSG1_uc002ouy.1_Silent_p.E160E|PSG1_uc002ouz.1_Silent_p.E160E|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Silent_p.E160E	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	160	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				CCTCCATGGTCTCCCTGGGAT	0.537													0	0	0	0.01441	0	61	270										T	43376148	C	T	43376148	2	4	42	1	0	0	0	0	0	0	0	1	12653	912	32	1		1	PSG1	19	43376148	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4515280	43376148	15752835	320	11060										
MARK4	57787	broad.mit.edu	37	chr19	45774817	45774817	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcacgctgggatcgaagctgGacacgttctgcgggagcccc	14	13	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:45774817G>C	uc002pbb.1	+	8	642	c.637G>C	c.(637-639)GAC>CAC	p.D213H	MARK4_uc002paz.1_Missense_Mutation_p.W23C|MARK4_uc002pba.1_Missense_Mutation_p.D213H|MARK4_uc002pbc.1_Missense_Mutation_p.D79H			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	213	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ATCGAAGCTGGACACGTTCTG	0.597													0	0	0	0.01441	0	68	245										C	45774817	G	C	45774817	3	2	42	1	0	0	0	0	1	0	0	0	9315	1174	41	1	667	1	MARK4	19	45774817	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2398669	45774817	13354166	321	11061										
SYMPK	8189	broad.mit.edu	37	chr19	46338423	46338423	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgtgcctgctgactccacggGggtgtagatggcctggaagg	17	10	0	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46338423G>C	uc002pdn.2	-	11	1551	c.1306C>G	c.(1306-1308)CCC>GCC	p.P436A	SYMPK_uc002pdo.1_Missense_Mutation_p.P436A|SYMPK_uc002pdp.1_Missense_Mutation_p.P436A|SYMPK_uc002pdq.1_Missense_Mutation_p.P436A	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	436					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GACTCCACGGGGGTGTAGATG	0.602													0	0	0	0.01441	0	99	62										C	46338423	G	C	46338423	3	2	42	1	0	0	0	0	1	0	0	0	15436	1232	43	4	2586	4	SYMPK	19	46338423	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	563606	46338423	12790560	322	11062										
MYPOP	339344	broad.mit.edu	37	chr19	46393930	46393930	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tccgtgtagggaaaccttttCtccgcttgtgtgggggggag	16	8	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46393930C>G	uc002pdt.2	-	3	1238	c.1151G>C	c.(1150-1152)AGA>ACA	p.R384T		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	384	Nuclear localization signal (By similarity).					nucleus	DNA binding				0						GAAACCTTTTCTCCGCTTGTG	0.642													0	0	0	0.011902	0	43	124										G	46393930	C	G	46393930	3	3	42	1	0	0	0	0	1	0	0	0	10099	913	32	1	52	1	MYPOP	19	46393930	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	55507	46393930	12735053	323	11063										
PGLYRP1	8993	broad.mit.edu	37	chr19	46522875	46522875	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagttccagccacggccctcGtatacgagcccgtcttctcc	8	17	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46522875G>A	uc002pdx.1	-	2	362	c.318C>T	c.(316-318)TAC>TAT	p.Y106Y		NM_005091	NP_005082	O75594	PGRP1_HUMAN	peptidoglycan recognition protein 1 precursor	106					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region	bacterial cell surface binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)	2		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		CACGGCCCTCGTATACGAGCC	0.587													0	0	0	0.00632	0	24	138										A	46522875	G	A	46522875	2	1	42	1	0	0	0	0	0	0	0	1	11793	1140	40	2		2	PGLYRP1	19	46522875	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	128945	46522875	12606108	324	11064										
PRKD2	25865	broad.mit.edu	37	chr19	47178369	47178369	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gcagcaggttgttgatgaggTcaatggctgcacaggaaaga	15	6	1	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:47178369T>C	uc002pfh.2	-	18	2687	c.2345A>G	c.(2344-2346)GAC>GGC	p.D782G	PRKD2_uc002pfd.2_Missense_Mutation_p.D156G|PRKD2_uc010eks.2_Missense_Mutation_p.D185G|PRKD2_uc010ekt.2_Missense_Mutation_p.D49G|PRKD2_uc002pfe.2_Missense_Mutation_p.D312G|PRKD2_uc002pff.2_Missense_Mutation_p.D302G|PRKD2_uc002pfg.2_Missense_Mutation_p.D625G|PRKD2_uc002pfi.2_Missense_Mutation_p.D782G|PRKD2_uc002pfj.2_Missense_Mutation_p.D782G|PRKD2_uc010xye.1_Missense_Mutation_p.D792G|PRKD2_uc002pfk.2_Missense_Mutation_p.D625G	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	782	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GTTGATGAGGTCAATGGCTGC	0.567													0	0	0	0.010818	0	31	20										C	47178369	T	C	47178369	3	2	42	1	0	0	0	0	1	0	0	0	12519	1667	58	5	299	5	PRKD2	19	47178369	Missense_Mutation	SNP	T	TCGA-DK-A1A6-01A-11D-A13W-08	655494	47178369	11950614	325	11065										
NLRP9	338321	broad.mit.edu	37	chr19	56244156	56244156	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cccctctctagcctctgtttCacacaagtacagaccaacca	4	17	3	1	rs146611098		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:56244156C>T	uc002qly.2	-	2	1069	c.1041G>A	c.(1039-1041)GTG>GTA	p.V347V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	347	NACHT.					cytoplasm	ATP binding	p.V347V(1)		skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GCCTCTGTTTCACACAAGTAC	0.418													0	0	0	0.01441	0	209	35										T	56244156	C	T	56244156	2	4	42	1	0	0	0	0	0	0	0	1	10484	813	29	1		1	NLRP9	19	56244156	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	9065787	56244156	2884827	326	11066										
NLRP9	338321	broad.mit.edu	37	chr19	56244288	56244288	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagtaggagaaatacgacttCttttcagattcactgaatcc	7	8	3	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:56244288C>G	uc002qly.2	-	2	937	c.909G>C	c.(907-909)AAG>AAC	p.K303N		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	303	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AATACGACTTCTTTTCAGATT	0.388													0	0	0	0.01441	0	112	25										G	56244288	C	G	56244288	3	3	42	1	0	0	0	0	1	0	0	0	10484	912	32	1	2098	1	NLRP9	19	56244288	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	132	56244288	2884695	327	11067										
ZNF274	10782	broad.mit.edu	37	chr19	58724434	58724434	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaatgtggaaaggccttcacCcagagctcacaccttattgg	9	11	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:58724434C>A	uc002qrq.1	+	10	2346	c.1887C>A	c.(1885-1887)ACC>ACA	p.T629T	ZNF274_uc002qrr.1_Silent_p.T597T|ZNF274_uc002qrs.1_Silent_p.T524T|ZNF274_uc010eum.1_Silent_p.T388T	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	629	C2H2-type 5.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		AGGCCTTCACCCAGAGCTCAC	0.517													1	0	2.40228e-13	0.013114	2.53018e-13	46	409										A	58724434	C	A	58724434	2	1	42	1	0	0	0	0	0	0	0	1	17806	610	22	4		4	ZNF274	19	58724434	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2480146	58724434	404549	328	11068										
SIRPG	55423	broad.mit.edu	37	chr20	1638344	1638344	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gaccaggaggatggggccagGaggctgggacaggcattttg	19	7	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:1638344G>A	uc002wfm.1	-	1	82	c.17C>T	c.(16-18)TCC>TTC	p.S6F	SIRPG_uc002wfn.1_Missense_Mutation_p.S6F|SIRPG_uc002wfo.1_Missense_Mutation_p.S6F	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	6					blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						ATGGGGCCAGGAGGCTGGGAC	0.557													0	0	0	0.01441	0	72	48										A	1638344	G	A	1638344	3	1	42	1	0	0	0	0	1	0	0	0	14336	1174	41	1	1166	1	SIRPG	20	1638344	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		1638344	61387176	329	11069										
FASTKD5	60493	broad.mit.edu	37	chr20	3128585	3128585	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcgctgaggagctatctctcCaatctgcttcatgaaattga	8	10	3	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:3128585C>T	uc002whz.2	-	2	1443	c.1132G>A	c.(1132-1134)GGA>AGA	p.G378R	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	378					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						GCTATCTCTCCAATCTGCTTC	0.443													0	0	0	0.009535	0	32	133										T	3128585	C	T	3128585	3	4	42	1	0	0	0	0	1	0	0	0	5688	603	21	2	1166	2	FASTKD5	20	3128585	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1490241	3128585	59896935	330	11070										
PLCB1	23236	broad.mit.edu	37	chr20	8678319	8678319	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gttgagatgtatcgccaagtGctcctgtctggttgtcgctg	13	9	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:8678319G>C	uc002wnb.2	+	11	1059	c.1056G>C	c.(1054-1056)GTG>GTC	p.V352V	PLCB1_uc010zrb.1_Silent_p.V251V|PLCB1_uc002wna.2_Silent_p.V352V|PLCB1_uc002wnc.1_Silent_p.V251V	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	352	PI-PLC X-box.			V -> A (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ATCGCCAAGTGCTCCTGTCTG	0.512													0	0	0	0.01441	0	116	39										C	8678319	G	C	8678319	2	2	42	1	0	0	0	0	0	0	0	1	12027	1306	46	4		4	PLCB1	20	8678319	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	5549734	8678319	54347201	331	11071										
SLC24A3	57419	broad.mit.edu	37	chr20	19677543	19677543	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	actgcatggccagcctcattGtggccagacaaggtgggact	13	11	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:19677543G>C	uc002wrl.2	+	14	1791	c.1594G>C	c.(1594-1596)GTG>CTG	p.V532L		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	532	Cytoplasmic (Potential).|Alpha-2.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CAGCCTCATTGTGGCCAGACA	0.383													0	0	0	0.01441	0	55	15										C	19677543	G	C	19677543	3	2	42	1	0	0	0	0	1	0	0	0	14467	1377	48	4	1648	4	SLC24A3	20	19677543	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	10999224	19677543	43347977	332	11072										
MYLK2	85366	broad.mit.edu	37	chr20	30408244	30408244	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agcctcaggcagccaggatcCtggaaagcccagggtgggca	15	12	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:30408244C>T	uc002wwq.2	+	3	470	c.368C>T	c.(367-369)CCT>CTT	p.P123L		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	123					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGCCAGGATCCTGGAAAGCCC	0.657													0	0	0	0.006999	0	39	112										T	30408244	C	T	30408244	3	4	42	1	0	0	0	0	1	0	0	0	10057	681	24	2	374	2	MYLK2	20	30408244	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	10730701	30408244	32617276	333	11073										
PLAGL2	5326	broad.mit.edu	37	chr20	30784258	30784258	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gagggcctctgtgggggctaCtggaatgcttgatggaaacg	17	7	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:30784258C>T	uc002wxn.2	-	3	1705	c.1488G>A	c.(1486-1488)CAG>CAA	p.Q496Q		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	496						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTGGGGGCTACTGGAATGCTT	0.577													0	0	0	0.01441	0	58	202										T	30784258	C	T	30784258	2	4	42	1	0	0	0	0	0	0	0	1	12020	564	20	2		2	PLAGL2	20	30784258	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	376014	30784258	32241262	334	11074										
MYH7B	57644	broad.mit.edu	37	chr20	33575921	33575921	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	agcttcgaacagctgtgcatCaacttcaccaatgagaaatt	7	10	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:33575921C>G	uc002xbi.1	+	17	1661	c.1569C>G	c.(1567-1569)ATC>ATG	p.I523M	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	481	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity	p.I523M(1)		ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGCTGTGCATCAACTTCACCA	0.562													0	0	0	0.01441	0	170	175										G	33575921	C	G	33575921	3	3	42	1	0	0	0	0	1	0	0	0	10040	816	29	1	1635	1	MYH7B	20	33575921	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2791663	33575921	29449599	335	11075										
C20orf132	140699	broad.mit.edu	37	chr20	35731106	35731106	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtttctaggcagaggacctgCccatgagcttctgcaaccag	11	12	2	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:35731106C>T	uc010zvu.1	-	26	3234	c.3143G>A	c.(3142-3144)GGC>GAC	p.G1048D	C20orf132_uc002xgk.2_Missense_Mutation_p.G670D	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:Variant_position_missing_in_Q9H579_after_alignment											0		Myeloproliferative disorder(115;0.00878)				AGAGGACCTGCCCATGAGCTT	0.512													0	0	0	0.01441	0	208	525										T	35731106	C	T	35731106	3	4	42	1	0	0	0	0	1	0	0	0	2086	739	26	2	19	2	C20orf132	20	35731106	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2155185	35731106	27294414	336	11076										
PLCG1	5335	broad.mit.edu	37	chr20	39797452	39797452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	acaaggcccagagggaggacGagctgaccttcatcaagagc	13	11	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:39797452G>A	uc002xjp.1	+	21	2546	c.2425G>A	c.(2425-2427)GAG>AAG	p.E809K	PLCG1_uc002xjo.1_Missense_Mutation_p.E809K|PLCG1_uc010zwe.1_Missense_Mutation_p.E435K|PLCG1_uc010ggf.2_Missense_Mutation_p.E133K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	809	SH3.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GAGGGAGGACGAGCTGACCTT	0.577													0	0	0	0.00623	0	37	29										A	39797452	G	A	39797452	3	1	42	1	0	0	0	0	1	0	0	0	12035	1059	37	1	2507	1	PLCG1	20	39797452	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	4066346	39797452	23228068	337	11077										
PTPRT	11122	broad.mit.edu	37	chr20	40790057	40790057	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgtgatgtgctgcagcaagtCagccacccggatggcgggtt	15	11	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:40790057C>A	uc002xkg.2	-	17	2801	c.2617G>T	c.(2617-2619)GAC>TAC	p.D873Y	PTPRT_uc010ggj.2_Missense_Mutation_p.D892Y|PTPRT_uc010ggi.2_Missense_Mutation_p.D76Y	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	873	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGCAGCAAGTCAGCCACCCGG	0.597													1	0	5.25376e-55	0.01441	5.73252e-55	96	79										A	40790057	C	A	40790057	3	1	42	1	0	0	0	0	1	0	0	0	12812	826	29	3	1768	3	PTPRT	20	40790057	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	992605	40790057	22235463	338	11078										
EYA2	2139	broad.mit.edu	37	chr20	45633580	45633580	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atcttccctctttccacacaGatcttgcccacgtgtcctcc	4	18	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:45633580G>C	uc002xsm.2	+	4	530	c.156_splice	c.e4-1	p.R52_splice	EYA2_uc010ghp.2_Splice_Site_p.R52_splice|EYA2_uc002xsn.2_Splice_Site_p.R57_splice|EYA2_uc002xso.2_Splice_Site_p.R52_splice|EYA2_uc002xsp.2_Splice_Site_p.R52_splice|EYA2_uc002xsq.2_Splice_Site_p.R52_splice	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a						DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				TTTCCACACAGATCTTGCCCA	0.552													0	0	0	0.01441	0	93	71										C	45633580	G	C	45633580	5	2	42	1	0	0	0	0	0	0	1	0	5329	956	33	1	165	1	EYA2	20	45633580	Splice_Site	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	4843523	45633580	17391940	339	11079										
ARFGEF2	10564	broad.mit.edu	37	chr20	47592610	47592610	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gaaaggccttgacatggcaaGacggtgtagtgtgacgtcca	14	8	0	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:47592610G>A	uc002xtx.3	+	14	1984	c.1832G>A	c.(1831-1833)AGA>AAA	p.R611K		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	611					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GACATGGCAAGACGGTGTAGT	0.507													0	0	0	0.010729	0	12	85										A	47592610	G	A	47592610	3	1	42	1	0	0	0	0	1	0	0	0	853	942	33	1	1886	1	ARFGEF2	20	47592610	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1959030	47592610	15432910	340	11080										
DIDO1	11083	broad.mit.edu	37	chr20	61511837	61511837	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggtaagagggtgaggggcctCtgctgtccccataaggaggt	17	8	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:61511837C>G	uc002ydr.1	-	16	5735	c.5471G>C	c.(5470-5472)AGA>ACA	p.R1824T	DIDO1_uc002yds.1_Missense_Mutation_p.R1824T	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1824	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TGAGGGGCCTCTGCTGTCCCC	0.617													0	0	0	0.01441	0	482	358										G	61511837	C	G	61511837	3	3	42	1	0	0	0	0	1	0	0	0	4522	913	32	1	1255	1	DIDO1	20	61511837	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	13919227	61511837	1513683	341	11081										
CHRNA4	1137	broad.mit.edu	37	chr20	61981890	61981890	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gacgggatgatctcggtgatGagcagcaggaagacggtgag	18	6	1	5			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:61981890G>C	uc002yes.2	-	5	1051	c.873C>G	c.(871-873)CTC>CTG	p.L291L	CHRNA4_uc002yet.1_Silent_p.L115L|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.L220L|CHRNA4_uc002yev.1_Silent_p.L115L|CHRNA4_uc010gkf.1_Silent_p.L115L	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	291	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCTCGGTGATGAGCAGCAGGA	0.592													0	0	0	0.01441	0	76	453										C	61981890	G	C	61981890	2	2	42	1	0	0	0	0	0	0	0	1	3385	1277	45	1		1	CHRNA4	20	61981890	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	470053	61981890	1043630	342	11082										
ZBTB46	140685	broad.mit.edu	37	chr20	62421703	62421703	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tccgcaagctcatctgaggcGtccgacttgatgctgatgtc	11	12	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:62421703G>A	uc002ygv.1	-	2	609	c.408C>T	c.(406-408)GAC>GAT	p.D136D	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CATCTGAGGCGTCCGACTTGA	0.617													0	0	0	0.016522	0	22	151										A	62421703	G	A	62421703	2	1	42	1	0	0	0	0	0	0	0	1	17544	1136	40	2		2	ZBTB46	20	62421703	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	439813	62421703	603817	343	11083										
TMPRSS15	5651	broad.mit.edu	37	chr21	19715873	19715873	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttgtccataattccaattgtCtccataatttccttcctttt	2	11	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:19715873C>T	uc002ykw.2	-	12	1409	c.1378G>A	c.(1378-1380)GAC>AAC	p.D460N		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	460	Extracellular (Potential).|MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTCCAATTGTCTCCATAATTT	0.294													0	0	0	0.01441	0	378	71										T	19715873	C	T	19715873	3	4	42	1	0	0	0	0	1	0	0	0	16243	913	32	1	1737	1	TMPRSS15	21	19715873	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		19715873	28414022	344	11084										
SETD4	54093	broad.mit.edu	37	chr21	37429482	37429482	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cttcctcagctctataaattCagacttgtggctctcattca	5	12	5	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:37429482C>G	uc002yuw.1	-	2	1467	c.94G>C	c.(94-96)GAA>CAA	p.E32Q	SETD4_uc002yux.1_Missense_Mutation_p.E8Q|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.E32Q|SETD4_uc002yuy.2_Missense_Mutation_p.E32Q|SETD4_uc002yuz.2_Missense_Mutation_p.E8Q|SETD4_uc002yva.2_Missense_Mutation_p.E8Q	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	32										large_intestine(1)|ovary(1)	2						TCTATAAATTCAGACTTGTGG	0.398													0	0	0	0.00333	0	25	106										G	37429482	C	G	37429482	3	3	42	1	0	0	0	0	1	0	0	0	14133	835	29	1	1287	1	SETD4	21	37429482	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	17713609	37429482	10700413	345	11085										
BRWD1	54014	broad.mit.edu	37	chr21	40578084	40578084	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttacaattttgccgttgcttGaacctctggcttcttcgaag	8	10	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:40578084G>C	uc002yxk.1	-	37	4453	c.4314C>G	c.(4312-4314)TTC>TTG	p.F1438L	BRWD1_uc010goc.1_Missense_Mutation_p.F81L|BRWD1_uc002yxl.2_Missense_Mutation_p.F1438L|BRWD1_uc010god.1_Missense_Mutation_p.F356L	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GCCGTTGCTTGAACCTCTGGC	0.303													0	0	0	0.01441	0	55	230										C	40578084	G	C	40578084	3	2	42	1	0	0	0	0	1	0	0	0	1525	1281	45	1	2911	1	BRWD1	21	40578084	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	3148602	40578084	7551811	346	11086										
COL6A2	1292	broad.mit.edu	37	chr21	47531978	47531978	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcccccacggacatcctgctCttccacatgaagcagttcgt	7	16	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:47531978C>G	uc002zia.1	+	3	283	c.201C>G	c.(199-201)CTC>CTG	p.L67L	COL6A2_uc002zhy.1_Silent_p.L67L|COL6A2_uc002zhz.1_Silent_p.L67L|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	67	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACATCCTGCTCTTCCACATGA	0.617													0	0	0	0.01441	0	53	179										G	47531978	C	G	47531978	2	3	42	1	0	0	0	0	0	0	0	1	3700	900	32	1		1	COL6A2	21	47531978	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	6953894	47531978	597917	347	11087										
CCT8L2	150160	broad.mit.edu	37	chr22	17072001	17072001	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tttattatcccttcagttccCacacccattaggaggttccc	5	14	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:17072001C>T	uc002zlp.1	-	1	1700	c.1440G>A	c.(1438-1440)GTG>GTA	p.V480V		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	480					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTTCAGTTCCCACACCCATTA	0.512													0	0	0	0.01441	0	118	225										T	17072001	C	T	17072001	2	4	42	1	0	0	0	0	0	0	0	1	2961	581	21	2		2	CCT8L2	22	17072001	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08		17072001	34232565	348	11088										
TXNRD2	10587	broad.mit.edu	37	chr22	19870908	19870908	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	gtggcttcccgggagtccacCaggatcttctgagtgtcggg	15	11	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:19870908C>T	uc011ahc.1	-	12	1059	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L	TXNRD2_uc002zql.1_Silent_p.L96L|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.L341L|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_5'Flank	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	342					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GGGAGTCCACCAGGATCTTCT	0.617													0	0	0	0.01441	0	148	217										T	19870908	C	T	19870908	2	4	42	1	0	0	0	0	0	0	0	1	16805	581	21	2		2	TXNRD2	22	19870908	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2798907	19870908	31433658	349	11089										
TRMT2A	27037	broad.mit.edu	37	chr22	20100675	20100675	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggtgggtccaggatggccacGaggtgctgggaggccagtct	19	9	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:20100675G>A	uc002zrk.1	-	11	1730	c.1515C>T	c.(1513-1515)CTC>CTT	p.L505L	TRMT2A_uc002zrl.1_Silent_p.L505L|TRMT2A_uc002zrm.1_Silent_p.L327L|TRMT2A_uc002zrn.1_Silent_p.L523L	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	505					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						GGATGGCCACGAGGTGCTGGG	0.612													0	0	0	0.01441	0	88	172										A	20100675	G	A	20100675	2	1	42	1	0	0	0	0	0	0	0	1	16562	1045	37	1		1	TRMT2A	22	20100675	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	229767	20100675	31203891	350	11090										
LARGE	9215	broad.mit.edu	37	chr22	33777913	33777913	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tgttgaccctacctttagatCagacacgtctctgtagcact	7	12	2	3			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:33777913C>A	uc003and.3	-	10	1702	c.1123G>T	c.(1123-1125)GAT>TAT	p.D375Y	LARGE_uc011amd.1_Missense_Mutation_p.D174Y|LARGE_uc003ane.3_Missense_Mutation_p.D375Y|LARGE_uc010gwp.2_Missense_Mutation_p.D375Y|LARGE_uc011ame.1_Missense_Mutation_p.D307Y|LARGE_uc011amf.1_Missense_Mutation_p.D375Y|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	375	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				ACCTTTAGATCAGACACGTCT	0.562													1	0	3.57733e-08	0.009535	3.69928e-08	30	145										A	33777913	C	A	33777913	3	1	42	1	0	0	0	0	1	0	0	0	8627	826	29	3	1175	3	LARGE	22	33777913	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	13677238	33777913	17526653	351	11091										
LARGE	9215	broad.mit.edu	37	chr22	33780253	33780253	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctccacatctgctcccatttCatcttccgcagcttatccag	4	17	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:33780253C>A	uc003and.3	-	9	1509	c.930G>T	c.(928-930)ATG>ATT	p.M310I	LARGE_uc011amd.1_Missense_Mutation_p.M109I|LARGE_uc003ane.3_Missense_Mutation_p.M310I|LARGE_uc010gwp.2_Missense_Mutation_p.M310I|LARGE_uc011ame.1_Missense_Mutation_p.M242I|LARGE_uc011amf.1_Missense_Mutation_p.M310I|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	310	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GCTCCCATTTCATCTTCCGCA	0.493													1	0	1.31726e-23	0.01441	1.40364e-23	60	101										A	33780253	C	A	33780253	3	1	42	1	0	0	0	0	1	0	0	0	8627	826	29	3	1372	3	LARGE	22	33780253	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2340	33780253	17524313	352	11092										
NOL12	79159	broad.mit.edu	37	chr22	38087186	38087186	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tctgccctcccctaggatctCctccctcacagcatcactac	4	20	4	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:38087186C>G	uc003atp.2	+	6	541	c.485C>G	c.(484-486)TCC>TGC	p.S162C	NOL12_uc011anm.1_3'UTR|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	162						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					CCTAGGATCTCCTCCCTCACA	0.577													0	0	0	0.01441	0	67	141										G	38087186	C	G	38087186	3	3	42	1	0	0	0	0	1	0	0	0	10522	855	30	1	507	1	NOL12	22	38087186	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	4306933	38087186	13217380	353	11093										
SCO2	9997	broad.mit.edu	37	chr22	50962178	50962178	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atggcaatggagtggtccacGatgtagtcctggtcctcatc	12	10	1	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:50962178G>T	uc003bma.2	-	2	839	c.663C>A	c.(661-663)ATC>ATA	p.I221I	SCO2_uc003blz.3_Silent_p.I221I	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	221	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGTGGTCCACGATGTAGTCCT	0.572													1	0	4.83248e-46	0.01441	5.24769e-46	75	433										T	50962178	G	T	50962178	2	4	42	1	0	0	0	0	0	0	0	1	13932	1048	37	3		3	SCO2	22	50962178	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	12874992	50962178	342388	354	11094										
DDX53	168400	broad.mit.edu	37	chrX	23019522	23019522	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aaaatataattgttaccacaGaaaaagaaaaacgagctctc	5	7	1	2			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:23019522G>C	uc004daj.2	+	1	1436	c.1348G>C	c.(1348-1350)GAA>CAA	p.E450Q		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	450	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						TGTTACCACAGAAAAAGAAAA	0.353													0	0	0	0.001168	0	6	75										C	23019522	G	C	23019522	3	2	42	1	0	0	0	0	1	0	0	0	4371	943	33	1	1350	1	DDX53	23	23019522	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08		23019522	132251038	355	11095										
FAM47A	158724	broad.mit.edu	37	chrX	34148659	34148659	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	tcctgaagcagttcttttatGtaggatgctcgaatcttggg	11	7	2	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:34148659G>A	uc004ddg.2	-	1	1770	c.1737C>T	c.(1735-1737)TAC>TAT	p.Y579Y		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	579										ovary(4)|central_nervous_system(1)	5						GTTCTTTTATGTAGGATGCTC	0.483													0	0	0	0.00874	0	43	10										A	34148659	G	A	34148659	2	1	42	1	0	0	0	0	0	0	0	1	5569	1372	48	2		2	FAM47A	23	34148659	Silent	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	11129137	34148659	121121901	356	11096										
RPGR	6103	broad.mit.edu	37	chrX	38147249	38147249	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttcatcactatcatcgttttCagtaagagctgtatcctgcg	7	10	4	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:38147249C>G	uc004ded.1	-	14	1786	c.1618G>C	c.(1618-1620)GAA>CAA	p.E540Q	RPGR_uc004deb.2_Missense_Mutation_p.E540Q|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	540	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCATCGTTTTCAGTAAGAGCT	0.358													0	0	0	0.01441	0	44	15										G	38147249	C	G	38147249	3	3	42	1	0	0	0	0	1	0	0	0	13548	835	29	1	2407	1	RPGR	23	38147249	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	3998590	38147249	117123311	357	11097										
MED14	9282	broad.mit.edu	37	chrX	40540142	40540142	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atgtggaatttttgatggatCgaattccattggatactaat	9	4	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:40540142C>A	uc004dex.3	-	20	2618	c.2478G>T	c.(2476-2478)TCG>TCT	p.S826S		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	826					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						TTTGATGGATCGAATTCCATT	0.328													1	0	6.4e-05	0.004672	6.5e-05	3	14										A	40540142	C	A	40540142	2	1	42	1	0	0	0	0	0	0	0	1	9432	871	31	3		3	MED14	23	40540142	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	2392893	40540142	114730418	358	11098										
KDM6A	7403	broad.mit.edu	37	chrX	44950105	44950111	+	Splice_Site	DEL	ATTAAGT	ATTAAGT	-													0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atccaaagctttttgaaatgAttaagtaagtcttttctaaa					rs148188315		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			ATTAAGT	-	ATTAAGT	ATTAAGT		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:44950105_44950111delATTAAGT	uc004dge.3	+	26	4253	c.3878_splice	c.e26+1	p.K1293_splice	KDM6A_uc011mkz.1_Splice_Site_p.K1345_splice|KDM6A_uc011mla.1_Splice_Site_p.K1248_splice|KDM6A_uc011mlb.1_Splice_Site_p.K1300_splice|KDM6A_uc011mlc.1_Splice_Site_p.K997_splice|KDM6A_uc011mld.1_Splice_Site_p.K932_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTTTGAAATGATTAAGTAAGTCTTTTC	0.353			D|N|F|S		renal|oesophageal SCC|MM													18	16	---	---								-	44950111	ATTAAGT	-	44950105	8	5	42	1	0	1	0	1	0	0	1	0	8137	333	12	0	3976	0	KDM6A	23	44950105	Splice_Site	DEL	ATTAAGT	TCGA-DK-A1A6-01A-11D-A13W-08	4409963	44950105	110320455	359	11099										
HUWE1	10075	broad.mit.edu	37	chrX	53578103	53578103	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ggggtgtctgagctggcattCtgtgctagttctcgtcgctg	15	9	3	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:53578103C>T	uc004dsp.2	-	65	9546	c.9144G>A	c.(9142-9144)CAG>CAA	p.Q3048Q	HUWE1_uc004dsn.2_Silent_p.Q1856Q	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3048					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGCTGGCATTCTGTGCTAGTT	0.562													0	0	0	0.010771	0	45	15										T	53578103	C	T	53578103	2	4	42	1	0	0	0	0	0	0	0	1	7461	912	32	1		1	HUWE1	23	53578103	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	8627998	53578103	101692457	360	11100										
HUWE1	10075	broad.mit.edu	37	chrX	53578136	53578136	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cgtcgctgctgctcagctctCtgctgtgccagtacctatgg	11	14	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:53578136C>G	uc004dsp.2	-	65	9513	c.9111G>C	c.(9109-9111)CAG>CAC	p.Q3037H	HUWE1_uc004dsn.2_Missense_Mutation_p.Q1845H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3037					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCTCAGCTCTCTGCTGTGCCA	0.577													0	0	0	0.005524	0	39	15										G	53578136	C	G	53578136	3	3	42	1	0	0	0	0	1	0	0	0	7461	912	32	1	4093	1	HUWE1	23	53578136	Missense_Mutation	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	33	53578136	101692424	361	11101										
TRO	7216	broad.mit.edu	37	chrX	54957054	54957054	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgggcaccaatgctagtttCggcagcacacttggcaccag	11	13	0	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:54957054C>T	uc004dtq.2	+	12	4004	c.3897C>T	c.(3895-3897)TTC>TTT	p.F1299F	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.F830F|TRO_uc004dtw.2_Silent_p.F902F|TRO_uc004dtx.2_Silent_p.F682F	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1299	49.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ATGCTAGTTTCGGCAGCACAC	0.582													0	0	0	0.01441	0	68	18										T	54957054	C	T	54957054	2	4	42	1	0	0	0	0	0	0	0	1	16571	883	31	1		1	TRO	23	54957054	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	1378918	54957054	100313506	362	11102										
UBQLN2	29978	broad.mit.edu	37	chrX	56590882	56590882	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	atggaaaatccctttgttcaGagcatgctttcgaatcccga	8	10	1	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:56590882G>C	uc004dus.2	+	1	811	c.576G>C	c.(574-576)CAG>CAC	p.Q192H	UBQLN2_uc011moq.1_Missense_Mutation_p.Q192H	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	192						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						CCTTTGTTCAGAGCATGCTTT	0.478													0	0	0	0.01441	0	59	22										C	56590882	G	C	56590882	3	2	42	1	0	0	0	0	1	0	0	0	16894	933	33	1	578	1	UBQLN2	23	56590882	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	1633828	56590882	98679678	363	11103										
CSTF2	1478	broad.mit.edu	37	chrX	100086569	100086569	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ctgcgaatgtcccaacccctCgaggcttgttaggagatgct	11	12	0	1			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:100086569C>A	uc004egh.2	+	9	1013	c.955C>A	c.(955-957)CGA>AGA	p.R319R	CSTF2_uc010nnd.2_Silent_p.R339R|CSTF2_uc004egi.2_Silent_p.R302R	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	319	Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						CCCAACCCCTCGAGGCTTGTT	0.532													1	0	9.82936e-54	0.01441	1.06994e-53	95	14										A	100086569	C	A	100086569	2	1	42	1	0	0	0	0	0	0	0	1	3984	876	31	3		3	CSTF2	23	100086569	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	43495687	100086569	55183991	364	11104										
ODZ1	10178	broad.mit.edu	37	chrX	123516590	123516590	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	aagttaattctaaattttctAattcaggtttgggaaatcca	6	5	3	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:123516590A>G	uc004euj.2	-	30	7413	c.7349T>C	c.(7348-7350)TTA>TCA	p.L2450S	ODZ1_uc011muj.1_Missense_Mutation_p.L2456S|ODZ1_uc010nqy.2_Missense_Mutation_p.L2457S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2450	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TAAATTTTCTAATTCAGGTTT	0.353													0	0	0	0.01441	0	100	24										G	123516590	A	G	123516590	3	3	42	1	0	0	0	0	1	0	0	0	10834	372	13	5	836	5	ODZ1	23	123516590	Missense_Mutation	SNP	A	TCGA-DK-A1A6-01A-11D-A13W-08	23430021	123516590	31753970	365	11105										
MAGEA4	4103	broad.mit.edu	37	chrX	151092370	151092370	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	ttacccactaccatcagcttCacttgctggaggcaacccaa	6	15	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:151092370C>T	uc004fez.2	+	3	390	c.234C>T	c.(232-234)TTC>TTT	p.F78F	MAGEA4_uc004ffa.2_Silent_p.F78F|MAGEA4_uc004ffb.2_Silent_p.F78F|MAGEA4_uc004ffc.2_Silent_p.F78F|MAGEA4_uc004ffd.2_Silent_p.F78F	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	78							protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCATCAGCTTCACTTGCTGGA	0.602													0	0	0	0.01441	0	90	25										T	151092370	C	T	151092370	2	4	42	1	0	0	0	0	0	0	0	1	9168	825	29	1		1	MAGEA4	23	151092370	Silent	SNP	C	TCGA-DK-A1A6-01A-11D-A13W-08	27575780	151092370	4178190	366	11106										
CTAG2	30848	broad.mit.edu	37	chrX	153880627	153880627	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.422343324250681	155	6.09232828311604e-51	3.72481596437915	5.12955904247441	2.72026132132266	0.014565661245888	0.0440357200457079	113	cctcgggtggcggcgggcctGgtgtaccaggtctctgttct	16	12	2	0			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:153880627G>A	uc004fmi.1	-	2	601	c.548C>T	c.(547-549)CCA>CTA	p.P183L	CTAG2_uc004fmh.1_Intron	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	183	Poly-Pro.					centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGGCGGGCCTGGTGTACCAGG	0.607													0	0	0	0.01441	0	117	37										A	153880627	G	A	153880627	3	1	42	1	0	0	0	0	1	0	0	0	3991	1348	47	2	227	2	CTAG2	23	153880627	Missense_Mutation	SNP	G	TCGA-DK-A1A6-01A-11D-A13W-08	2788257	153880627	1389933	367	11107										
C1orf86	199990	broad.mit.edu	37	chr1	2125504	2125504	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gctccgggctcaccgtgcgcAgtagctcggcccagagccgc	14	17	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:2125504A>T	uc001aiy.2	-	2	157	c.131T>A	c.(130-132)CTG>CAG	p.L44Q	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Intron	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	44											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CACCGTGCGCAGTAGCTCGGC	0.672													0	0	0	0.000602	0	5	27										T	2125504	A	T	2125504	3	4	43	1	0	0	0	0	1	0	0	0	2063	188	7	5	663	5	C1orf86	1	2125504	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08		2125504	247125117	1	11108										
UBE4B	10277	broad.mit.edu	37	chr1	10166548	10166548	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agcagtgcccgccagcagttCcagacagaggcccagcagca	12	15	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:10166548C>T	uc001aqs.3	+	7	1816	c.1103C>T	c.(1102-1104)TCC>TTC	p.S368F	UBE4B_uc001aqr.3_Intron|UBE4B_uc010oai.1_Intron|UBE4B_uc010oaj.1_Intron	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	368					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GCCAGCAGTTCCAGACAGAGG	0.652													0	0	0	0.001368	0	10	43										T	10166548	C	T	10166548	3	4	43	1	0	0	0	0	1	0	0	0	16880	855	30	1	1129	1	UBE4B	1	10166548	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	8041044	10166548	239084073	2	11109										
EPHA2	1969	broad.mit.edu	37	chr1	16477395	16477395	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccgaaggcttacatacccctTtgccatacgggtgtgtgagc	11	12	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:16477395T>C	uc001aya.1	-	2	286	c.149A>G	c.(148-150)AAA>AGA	p.K50R	EPHA2_uc010oca.1_Missense_Mutation_p.K50R	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	50	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACATACCCCTTTGCCATACGG	0.473													0	0	0	0.010504	0	17	130										C	16477395	T	C	16477395	3	2	43	1	0	0	0	0	1	0	0	0	5167	1841	64	5	2845	5	EPHA2	1	16477395	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	6310847	16477395	232773226	3	11110										
PADI1	29943	broad.mit.edu	37	chr1	17552363	17552363	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcttgctggtgaactgtgacCgggacaatcacaggtccgca	12	11	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:17552363C>T	uc001bah.1	+	5	558	c.466C>T	c.(466-468)CGG>TGG	p.R156W		NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	156					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GAACTGTGACCGGGACAATCA	0.597													0	0	0	0.007413	0	20	162										T	17552363	C	T	17552363	3	4	43	1	0	0	0	0	1	0	0	0	11377	643	23	2	484	2	PADI1	1	17552363	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	1074968	17552363	231698258	4	11111										
UBR4	23352	broad.mit.edu	37	chr1	19449357	19449357	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agtgtgtcatattgcaaggcGgagcctgagctggctgtaac	14	8	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:19449357G>C	uc001bbi.2	-	66	9790	c.9786C>G	c.(9784-9786)TCC>TCG	p.S3262S	UBR4_uc001bbk.1_Silent_p.S909S	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3262					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATTGCAAGGCGGAGCCTGAGC	0.562													0	0	0	0.002299	0	22	128										C	19449357	G	C	19449357	2	2	43	1	0	0	0	0	0	0	0	1	16901	1103	39	4		4	UBR4	1	19449357	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1896994	19449357	229801264	5	11112										
PLA2G2E	30814	broad.mit.edu	37	chr1	20248869	20248869	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gcccagcttctccagacgccCgtagcagcagtcgtgggcgt	13	15	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:20248869C>G	uc001bct.1	-	3	266	c.208G>C	c.(208-210)GGG>CGG	p.G70R		NM_014589	NP_055404	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE precursor	70					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAGACGCCCGTAGCAGCAG	0.612													0	0	0	0.001168	0	5	54										G	20248869	C	G	20248869	3	3	43	1	0	0	0	0	1	0	0	0	11998	652	23	4	228	4	PLA2G2E	1	20248869	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	799512	20248869	229001752	6	11113										
EPHA8	2046	broad.mit.edu	37	chr1	22903038	22903038	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgccgaccttggtgtgcggcGtctcaagctcaacacggagg	14	12	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:22903038G>A	uc001bfx.1	+	3	613	c.488G>A	c.(487-489)CGT>CAT	p.R163H	EPHA8_uc001bfw.2_Missense_Mutation_p.R163H	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	163	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGTGTGCGGCGTCTCAAGCTC	0.622													0	0	0	0.004482	0	9	87										A	22903038	G	A	22903038	3	1	43	1	0	0	0	0	1	0	0	0	5173	1145	40	2	498	2	EPHA8	1	22903038	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2654169	22903038	226347583	7	11114										
ASAP3	55616	broad.mit.edu	37	chr1	23763959	23763959	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctgcctgaaagtggtacgtcCggttgtctgtcgggagagaa	15	8	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:23763959C>T	uc001bha.2	-	13	1233	c.1109G>A	c.(1108-1110)CGG>CAG	p.R370Q	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_5'Flank|ASAP3_uc010odz.1_Missense_Mutation_p.R239Q|ASAP3_uc010oea.1_Missense_Mutation_p.R361Q|ASAP3_uc001bhb.2_5'UTR	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	370	PH.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GTGGTACGTCCGGTTGTCTGT	0.682													0	0	0	0.001984	0	7	92										T	23763959	C	T	23763959	3	4	43	1	0	0	0	0	1	0	0	0	1012	652	23	2	1654	2	ASAP3	1	23763959	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	860921	23763959	225486662	8	11115										
MYOM3	127294	broad.mit.edu	37	chr1	24392387	24392387	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggagccacacttgcctcttcAatgcagagaagtcccgttcc	9	14	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:24392387A>C	uc001bin.3	-	29	3691	c.3528T>G	c.(3526-3528)ATT>ATG	p.I1176M	MYOM3_uc001bil.3_Missense_Mutation_p.I69M|MYOM3_uc001bim.3_Missense_Mutation_p.I833M|MYOM3_uc001bio.2_Missense_Mutation_p.I1176M	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1176	Ig-like C2-type 3.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TTGCCTCTTCAATGCAGAGAA	0.547													0	0	0	0.00361	0	238	61										C	24392387	A	C	24392387	3	2	43	1	0	0	0	0	1	0	0	0	10093	126	5	5	821	5	MYOM3	1	24392387	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	628428	24392387	224858234	9	11116										
PTP4A2	8073	broad.mit.edu	37	chr1	32381498	32381498	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	taaatactacacactcactaGaacgtggattccttcttttt	4	10	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:32381498G>C	uc001bty.1	-	3	1181	c.187C>G	c.(187-189)CTA>GTA	p.L63V	PTP4A2_uc010ogs.1_Intron|PTP4A2_uc001btz.1_Missense_Mutation_p.L63V	NM_080391	NP_536316	Q12974	TP4A2_HUMAN	protein tyrosine phosphatase type IVA, member 2	63						early endosome|plasma membrane	prenylated protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity				0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)				ACACTCACTAGAACGTGGATT	0.254													0	0	0	0.010729	0	12	38										C	32381498	G	C	32381498	3	2	43	1	0	0	0	0	1	0	0	0	12771	933	33	1	332	1	PTP4A2	1	32381498	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	7989111	32381498	216869123	10	11117										
CSF3R	1441	broad.mit.edu	37	chr1	36941192	36941192	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccagatggctgcagttctgCttgatgatgcaggaggctgt	14	8	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:36941192C>T	uc001caw.1	-	4	325	c.147G>A	c.(145-147)AAG>AAA	p.K49K	CSF3R_uc001cav.1_Silent_p.K49K|CSF3R_uc001cax.1_Silent_p.K49K|CSF3R_uc001cay.1_Silent_p.K49K	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	49	Ig-like C2-type.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGCAGTTCTGCTTGATGATGC	0.622													0	0	0	0.00278	0	20	17										T	36941192	C	T	36941192	2	4	43	1	0	0	0	0	0	0	0	1	3937	796	28	2		2	CSF3R	1	36941192	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	4559694	36941192	212309429	11	11118										
MPL	4352	broad.mit.edu	37	chr1	43804317	43804317	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggaagtgcgtctcttctttcCgctgcacctctgggtgaaga	12	11	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:43804317C>T	uc001ciw.2	+	3	362	c.317C>T	c.(316-318)CCG>CTG	p.P106L	MPL_uc001civ.2_Missense_Mutation_p.P106L|MPL_uc009vwr.2_Missense_Mutation_p.P99L	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	106	Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTTCTTTCCGCTGCACCTC	0.562			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						0	0	0	0.007835	0	42	41										T	43804317	C	T	43804317	3	4	43	1	0	0	0	0	1	0	0	0	9730	652	23	2	327	2	MPL	1	43804317	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	6863125	43804317	205446304	12	11119										
HYI	81888	broad.mit.edu	37	chr1	43917920	43917920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cctcaggttctccagaaaaaCggcctccatctcagccttga	7	15	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:43917920C>T	uc001cjo.2	-	3	552	c.382G>A	c.(382-384)GTT>ATT	p.V128I	KIAA0467_uc001cjk.1_3'UTR|KIAA0467_uc001cjl.1_3'UTR|HYI_uc001cjm.2_Missense_Mutation_p.V55I|HYI_uc001cjn.2_Missense_Mutation_p.V128I|HYI_uc001cjp.2_Missense_Mutation_p.V55I	NM_031207	NP_112484	Q5T013	HYI_HUMAN	hydroxypyruvate isomerase homolog	128							hydroxypyruvate isomerase activity			ovary(1)	1	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCCAGAAAAACGGCCTCCATC	0.562													0	0	0	0.004672	0	3	19										T	43917920	C	T	43917920	3	4	43	1	0	0	0	0	1	0	0	0	7468	536	19	2	475	2	HYI	1	43917920	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	113603	43917920	205332701	13	11120										
ZFYVE9	9372	broad.mit.edu	37	chr1	52704303	52704303	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	catgactaattggaagttgaCtaaactaaatgagatgaatg	9	4	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:52704303C>G	uc001cto.2	+	4	1386	c.1214C>G	c.(1213-1215)ACT>AGT	p.T405S	ZFYVE9_uc001ctn.2_Missense_Mutation_p.T405S|ZFYVE9_uc001ctp.2_Missense_Mutation_p.T405S	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	405					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TGGAAGTTGACTAAACTAAAT	0.373													0	0	0	0.010818	0	34	85										G	52704303	C	G	52704303	3	3	43	1	0	0	0	0	1	0	0	0	17668	565	20	4	1220	4	ZFYVE9	1	52704303	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	8786383	52704303	196546318	14	11121										
LPAR3	23566	broad.mit.edu	37	chr1	85331472	85331472	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgagggaagcagtcaagctaCtgtccagaagcccctgacgg	13	11	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:85331472C>T	uc001dkl.2	-	1	371	c.332G>A	c.(331-333)AGT>AAT	p.S111N	LPAR3_uc009wcj.1_Missense_Mutation_p.S111N	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	111	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						AGTCAAGCTACTGTCCAGAAG	0.498													0	0	0	0.00361	0	114	104										T	85331472	C	T	85331472	3	4	43	1	0	0	0	0	1	0	0	0	8906	565	20	2	737	2	LPAR3	1	85331472	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	32627169	85331472	163919149	15	11122										
ARHGAP29	9411	broad.mit.edu	37	chr1	94650459	94650459	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aagctctattttcaatctctGaggcacatattttgagtata	6	7	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:94650459G>T	uc001dqj.3	-	18	2447	c.2078C>A	c.(2077-2079)TCA>TAA	p.S693*	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Nonsense_Mutation_p.S259*	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	693	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTCAATCTCTGAGGCACATAT	0.333													1	0	1.45105e-14	0.006122	1.62725e-14	18	71										T	94650459	G	T	94650459	4	4	43	1	0	0	0	0	0	1	0	0	878	1294	45	3	1731	3	ARHGAP29	1	94650459	Nonsense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	9318987	94650459	154600162	16	11123										
KCNA2	3737	broad.mit.edu	37	chr1	111146201	111146201	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gacagggaccggtaaggcaaTagttaacacacctgcaatcg	11	10	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:111146201T>A	uc001dzu.2	-	2	1700	c.1204A>T	c.(1204-1206)ATT>TTT	p.I402F	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.I402F	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	402	Helical; Name=Segment S6; (Potential).					juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		GGTAAGGCAATAGTTAACACA	0.498													0	0	0	0.006999	0	41	46										A	111146201	T	A	111146201	3	1	43	1	0	0	0	0	1	0	0	0	8003	1406	49	5	299	5	KCNA2	1	111146201	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	16495742	111146201	138104420	17	11124										
CTTNBP2NL	55917	broad.mit.edu	37	chr1	112999502	112999502	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccaacggttccatgcagctcGccacaaatttcagtcccaag	7	15	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:112999502G>A	uc001ebx.2	+	6	1616	c.1388G>A	c.(1387-1389)CGC>CAC	p.R463H	CTTNBP2NL_uc001ebz.2_RNA	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	463						actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATGCAGCTCGCCACAAATTT	0.542													0	0	0	0.00623	0	40	120										A	112999502	G	A	112999502	3	1	43	1	0	0	0	0	1	0	0	0	4046	1087	38	2	1402	2	CTTNBP2NL	1	112999502	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1853301	112999502	136251119	18	11125										
HRNR	388697	broad.mit.edu	37	chr1	152187692	152187692	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tagatgactgtcctgatctaGagccgtgttgtccgtagcca	11	10	1	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:152187692G>A	uc001ezt.1	-	3	6489	c.6413C>T	c.(6412-6414)TCT>TTT	p.S2138F		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2138					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGATCTAGAGCCGTGTTG	0.572													0	0	0	0.002836	0	26	673										A	152187692	G	A	152187692	3	1	43	1	0	0	0	0	1	0	0	0	7359	942	33	1	2143	1	HRNR	1	152187692	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	39188190	152187692	97062929	19	11126										
ATP8B2	57198	broad.mit.edu	37	chr1	154321348	154321348	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cagctcgtgaggaagaagcaGaaggcccagcaccgctgcat	13	12	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:154321348G>C	uc001fex.2	+	28	3426	c.3426G>C	c.(3424-3426)CAG>CAC	p.Q1142H		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	1128	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGAAGAAGCAGAAGGCCCAGC	0.637													0	0	0	0.00245	0	11	7										C	154321348	G	C	154321348	3	2	43	1	0	0	0	0	1	0	0	0	1195	933	33	1	3666	1	ATP8B2	1	154321348	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2133656	154321348	94929273	20	11127										
CCDC19	25790	broad.mit.edu	37	chr1	159842832	159842832	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccctcctcaaaggtggcaatCcggttctgcacttccttctg	8	15	3	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:159842832C>G	uc001fui.2	-	11	1497	c.1479G>C	c.(1477-1479)CGG>CGC	p.R493R	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Silent_p.R408R|CCDC19_uc001ful.2_Silent_p.R408R	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	493	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			AGGTGGCAATCCGGTTCTGCA	0.592													0	0	0	0.00361	0	56	184										G	159842832	C	G	159842832	2	3	43	1	0	0	0	0	0	0	0	1	2795	842	30	1		1	CCDC19	1	159842832	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	5521484	159842832	89407789	21	11128										
VANGL2	57216	broad.mit.edu	37	chr1	160389046	160389046	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acggcctgcgagggcctcttCatctctgtcgccttcaagct	10	15	4	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:160389046C>A	uc001fwb.1	+	5	746	c.447C>A	c.(445-447)TTC>TTA	p.F149L	VANGL2_uc001fwc.1_Missense_Mutation_p.F149L	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	149	Helical; Name=2; (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGGCCTCTTCATCTCTGTCG	0.662													1	0	3.32936e-07	0.006122	3.51993e-07	18	171										A	160389046	C	A	160389046	3	1	43	1	0	0	0	0	1	0	0	0	17117	825	29	3	457	3	VANGL2	1	160389046	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	546214	160389046	88861575	22	11129										
CD244	51744	broad.mit.edu	37	chr1	160801216	160801216	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctttaggttgactctttccaAtctgcaaaagaaaaggagaa	8	7	2	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:160801216A>G	uc009wtq.2	-	9	1212	c.1034T>C	c.(1033-1035)ATT>ACT	p.I345T	CD244_uc001fxa.2_Missense_Mutation_p.I340T|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.I248T	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	345	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACTCTTTCCAATCTGCAAAAG	0.328													0	0	0	0.007291	0	27	306										G	160801216	A	G	160801216	3	3	43	1	0	0	0	0	1	0	0	0	2987	115	4	5	82	5	CD244	1	160801216	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	412170	160801216	88449405	23	11130										
SELL	6402	broad.mit.edu	37	chr1	169677940	169677940	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcggttccatgatgtgccagGaaatctgcaagacatcagtg	11	9	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:169677940G>A	uc001ggk.2	-	3	288	c.90C>T	c.(88-90)TTC>TTT	p.F30F	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_5'UTR|SELL_uc001ggl.1_Silent_p.F43F	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	30					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)					GATGTGCCAGGAAATCTGCAA	0.294													0	0	0	0.009096	0	4	4										A	169677940	G	A	169677940	2	1	43	1	0	0	0	0	0	0	0	1	14016	1165	41	1		1	SELL	1	169677940	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	8876724	169677940	79572681	24	11131										
ATP2B4	493	broad.mit.edu	37	chr1	203667472	203667472	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttttatcgccctgctggtgaAgaaaatgaacgtgagtgtcc	11	8	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:203667472A>G	uc001gzw.2	+	3	1265	c.381A>G	c.(379-381)GAA>GAG	p.E127E	ATP2B4_uc001gzv.2_Silent_p.E127E|ATP2B4_uc009xaq.2_Silent_p.E127E	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	127	Extracellular (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CTGCTGGTGAAGAAAATGAAC	0.483													0	0	0	0.012319	0	23	65										G	203667472	A	G	203667472	2	3	43	1	0	0	0	0	0	0	0	1	1142	69	3	5		5	ATP2B4	1	203667472	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	33989532	203667472	45583149	25	11132										
PIGR	5284	broad.mit.edu	37	chr1	207109079	207109079	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agtacttgatgcttttgcttTccttacggttgtaggggcag	12	7	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:207109079T>C	uc001hez.2	-	5	1314	c.1130A>G	c.(1129-1131)GAA>GGA	p.E377G	PIGR_uc009xbz.2_Missense_Mutation_p.E377G	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	377	Ig-like V-type 4.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GCTTTTGCTTTCCTTACGGTT	0.622											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	21	4										C	207109079	T	C	207109079	3	2	43	1	0	0	0	0	1	0	0	0	11897	1783	62	5	1192	5	PIGR	1	207109079	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	3441607	207109079	42141542	26	11133										
RYR2	6262	broad.mit.edu	37	chr1	237972206	237972209	+	Frame_Shift_Del	DEL	ATTA	ATTA	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cacattgttttccagctcgtAttaaccgttggcttattagc							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr1:237972206_237972209delATTA	uc001hyl.1	+	100	14424_14427	c.14304_14307delATTA	c.(14302-14307)GTATTAfs	p.V4768fs	RYR2_uc010pyb.1_Frame_Shift_Del_p.V201fs	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4768_4769	Helical; Name=M8; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCAGCTCGTATTAACCGTTGGCT	0.407																		46	306	---	---								-	237972209	ATTA	-	237972206	7	5	43	1	0	1	0	1	0	0	0	0	13769	436	16	0	14702	0	RYR2	1	237972206	Frame_Shift_Del	DEL	ATTA	TCGA-DK-A1A7-01A-11D-A13W-08	30863127	237972206	11278415	27	11134										
KIDINS220	57498	broad.mit.edu	37	chr2	8919858	8919858	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caggcatctaatccatcgatGatgaccaccagccttgtctg	8	13	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:8919858G>A	uc002qzc.2	-	18	2498	c.2316C>T	c.(2314-2316)ATC>ATT	p.I772I	KIDINS220_uc010yiv.1_Silent_p.I538I|KIDINS220_uc002qzd.2_Silent_p.I730I|KIDINS220_uc010yiw.1_Silent_p.I773I	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	772	KAP NTPase.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATCCATCGATGATGACCACCA	0.468													0	0	0	0.012319	0	21	36										A	8919858	G	A	8919858	2	1	43	1	0	0	0	0	0	0	0	1	8271	1280	45	1		1	KIDINS220	2	8919858	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08		8919858	234279515	28	11135										
CPSF3	51692	broad.mit.edu	37	chr2	9581956	9581956	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttctctcttagagcatggatCattttgatgacattggtccc	8	9	3	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:9581956C>T	uc002qzo.1	+	9	981	c.946C>T	c.(946-948)CAT>TAT	p.H316Y	CPSF3_uc010ewx.1_Missense_Mutation_p.H316Y|CPSF3_uc002qzp.1_Missense_Mutation_p.H279Y	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	316					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		GAGCATGGATCATTTTGATGA	0.398													0	0	0	0.006999	0	40	42										T	9581956	C	T	9581956	3	4	43	1	0	0	0	0	1	0	0	0	3826	826	29	1	980	1	CPSF3	2	9581956	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	662098	9581956	233617417	29	11136										
ROCK2	9475	broad.mit.edu	37	chr2	11367379	11367379	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaagttaaaatatttacttaCccactagcatctcataaagg	5	8	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:11367379C>T	uc002rbd.1	-	6	1317	c.868_splice	c.e6+1	p.G290_splice		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein						axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TATTTACTTACCCACTAGCAT	0.343													0	0	0	0.009535	0	32	137										T	11367379	C	T	11367379	5	4	43	1	0	0	0	0	0	0	1	0	13518	521	18	2	3409	2	ROCK2	2	11367379	Splice_Site	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	1785423	11367379	231831994	30	11137										
NT5C1B	93034	broad.mit.edu	37	chr2	18764244	18764244	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gatatagatcacggagtctaGcattgacatactgtagtgcc	10	8	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:18764244G>A	uc002rcz.2	-	7	1195	c.1091C>T	c.(1090-1092)GCT>GTT	p.A364V	NT5C1B_uc002rcy.2_Missense_Mutation_p.A364V|NT5C1B_uc010exr.2_Missense_Mutation_p.A306V|NT5C1B_uc010yju.1_Missense_Mutation_p.A304V|NT5C1B_uc002rda.2_Missense_Mutation_p.A304V|NT5C1B_uc010yjv.1_Missense_Mutation_p.A381V|NT5C1B_uc010yjw.1_Missense_Mutation_p.A347V|NT5C1B_uc010exs.2_Missense_Mutation_p.A366V	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	364					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				ACGGAGTCTAGCATTGACATA	0.473													0	0	0	0.002299	0	22	36										A	18764244	G	A	18764244	3	1	43	1	0	0	0	0	1	0	0	0	10686	971	34	2	757	2	NT5C1B	2	18764244	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	7396865	18764244	224435129	31	11138										
NLRC4	58484	broad.mit.edu	37	chr2	32475710	32475710	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tggacacatcctgcagttcgAaatcaaacttgtgggagaac	10	9	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:32475710A>T	uc002roi.2	-	4	1469	c.1223T>A	c.(1222-1224)TTC>TAC	p.F408Y	NLRC4_uc002roj.1_Missense_Mutation_p.F408Y|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	408	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTGCAGTTCGAAATCAAACTT	0.473													0	0	0	0.00278	0	23	9										T	32475710	A	T	32475710	3	4	43	1	0	0	0	0	1	0	0	0	10469	246	9	5	1875	5	NLRC4	2	32475710	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	13711466	32475710	210723663	32	11139										
BIRC6	57448	broad.mit.edu	37	chr2	32673877	32673877	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttcagatatggattatataGctcaccatttgatccagtcc	6	9	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:32673877G>A	uc010ezu.2	+	22	4633	c.4499G>A	c.(4498-4500)AGC>AAC	p.S1500N		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1500					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGATTATATAGCTCACCATTT	0.323													0	0	0	0.003954	0	24	91										A	32673877	G	A	32673877	3	1	43	1	0	0	0	0	1	0	0	0	1438	971	34	2	4585	2	BIRC6	2	32673877	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	198167	32673877	210525496	33	11140										
MAP4K3	8491	broad.mit.edu	37	chr2	39487881	39487881	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caggaactaccagcatttcaAacattctaagtggacatggt	8	9	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:39487881A>G	uc002rro.2	-	29	2265	c.2174T>C	c.(2173-2175)TTT>TCT	p.F725S	MAP4K3_uc002rrp.2_Missense_Mutation_p.F704S|MAP4K3_uc010yns.1_Missense_Mutation_p.F278S	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	725	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				CAGCATTTCAAACATTCTAAG	0.363													0	0	0	0.007413	0	17	45										G	39487881	A	G	39487881	3	3	43	1	0	0	0	0	1	0	0	0	9261	14	1	5	534	5	MAP4K3	2	39487881	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	6814004	39487881	203711492	34	11141										
CCDC88A	55704	broad.mit.edu	37	chr2	55544701	55544701	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acaaaatataataaattaccGgtcttcaaggtctctatgtt	5	7	3	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:55544701G>A	uc002ryv.2	-	20	4440	c.3598C>T	c.(3598-3600)CGT>TGT	p.R1200C	CCDC88A_uc010yoz.1_Missense_Mutation_p.R1201C|CCDC88A_uc010ypa.1_Missense_Mutation_p.R1200C|CCDC88A_uc002ryu.2_Missense_Mutation_p.R483C|CCDC88A_uc002rys.2_Missense_Mutation_p.R186C|CCDC88A_uc002ryw.2_Missense_Mutation_p.R484C|CCDC88A_uc010fby.1_Missense_Mutation_p.R80C	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1201	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						ATAAATTACCGGTCTTCAAGG	0.303													0	0	0	0.00333	0	24	101										A	55544701	G	A	55544701	3	1	43	1	0	0	0	0	1	0	0	0	2863	1130	39	2	2066	2	CCDC88A	2	55544701	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	16056820	55544701	187654672	35	11142										
CTNNA2	1496	broad.mit.edu	37	chr2	80101245	80101245	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggatgagatggcagccgcccGaggggctctgaagaagaatg	17	8	1	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:80101245G>T	uc010ysh.1	+	5	634	c.629G>T	c.(628-630)CGA>CTA	p.R210L	CTNNA2_uc010yse.1_Missense_Mutation_p.R210L|CTNNA2_uc010ysf.1_Missense_Mutation_p.R210L|CTNNA2_uc010ysg.1_Missense_Mutation_p.R210L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	210					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GCAGCCGCCCGAGGGGCTCTG	0.512													1	0	0.000157383	0.00308	0.000163637	8	39										T	80101245	G	T	80101245	3	4	43	1	0	0	0	0	1	0	0	0	4013	1058	37	3	647	3	CTNNA2	2	80101245	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	24556544	80101245	163098128	36	11143										
IFIH1	64135	broad.mit.edu	37	chr2	163136571	163136571	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tatttggtttttcagttgatCaaggttttctttaacagttt	7	4	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:163136571C>A	uc002uce.2	-	8	1798	c.1576G>T	c.(1576-1578)GAT>TAT	p.D526Y		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	526					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						TTCAGTTGATCAAGGTTTTCT	0.328													1	0	2.80507e-11	0.012213	3.05831e-11	32	40										A	163136571	C	A	163136571	3	1	43	1	0	0	0	0	1	0	0	0	7520	826	29	3	1537	3	IFIH1	2	163136571	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	83035326	163136571	80062802	37	11144										
LRP2	4036	broad.mit.edu	37	chr2	170062610	170062610	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cggttagacccatcttcagcCatggaattaatcatctggtt	8	10	4	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:170062610C>G	uc002ues.2	-	40	7692	c.7479G>C	c.(7477-7479)ATG>ATC	p.M2493I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2493	LDL-receptor class B 26.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CATCTTCAGCCATGGAATTAA	0.448													0	0	0	0.009718	0	42	60										G	170062610	C	G	170062610	3	3	43	1	0	0	0	0	1	0	0	0	8956	594	21	4	6648	4	LRP2	2	170062610	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	6926039	170062610	73136763	38	11145										
GAD1	2571	broad.mit.edu	37	chr2	171700564	171700564	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cacctttccaggtttacataTgaaattgcaccagtgtttgt	7	9	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:171700564T>A	uc002ugi.2	+	7	1070	c.648T>A	c.(646-648)TAT>TAA	p.Y216*		NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	216					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GGTTTACATATGAAATTGCAC	0.353													0	0	0	0.00245	0	14	33										A	171700564	T	A	171700564	4	1	43	1	0	0	0	0	0	1	0	0	6179	1471	51	5	711	5	GAD1	2	171700564	Nonsense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	1637954	171700564	71498809	39	11146										
TTN	7273	broad.mit.edu	37	chr2	179566962	179566962	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggctccagccgagcgatgacCgagtagacacctagggtgaa	14	11	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:179566962C>T	uc010zfg.1	-	105	26936	c.26712G>A	c.(26710-26712)TCG>TCA	p.S8904S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S5565S|TTN_uc010fre.1_Silent_p.S15S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9831							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGCGATGACCGAGTAGACAC	0.448													0	0	0	0.00308	0	6	21										T	179566962	C	T	179566962	2	4	43	1	0	0	0	0	0	0	0	1	16732	639	23	2		2	TTN	2	179566962	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	7866398	179566962	63632411	40	11147										
NIF3L1	60491	broad.mit.edu	37	chr2	201760010	201760010	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tggtaatgaggaacaaacacGgattaatctgaattgtactc	9	6	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:201760010G>A	uc002uwm.2	+	4	714	c.623G>A	c.(622-624)CGG>CAG	p.R208Q	NIF3L1_uc002uwl.2_Missense_Mutation_p.R181Q|NIF3L1_uc002uwn.2_Missense_Mutation_p.R181Q|NIF3L1_uc002uwo.2_Missense_Mutation_p.R208Q|NIF3L1_uc002uwp.2_Missense_Mutation_p.R208Q|NIF3L1_uc002uwq.2_Missense_Mutation_p.R208Q	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	208					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						GAACAAACACGGATTAATCTG	0.383													0	0	0	0.008871	0	18	155										A	201760010	G	A	201760010	3	1	43	1	0	0	0	0	1	0	0	0	10416	1116	39	2	633	2	NIF3L1	2	201760010	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	22193048	201760010	41439363	41	11148										
UGT1A1	54658	broad.mit.edu	37	chr2	234669219	234669219	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aagagtcttttgttagtctcGggcataatgtttttgagaat	10	4	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:234669219G>C	uc002vvb.2	+	1	301	c.286G>C	c.(286-288)GGG>CGG	p.G96R	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Missense_Mutation_p.G96R	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	96					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	TGTTAGTCTCGGGCATAATGT	0.428													0	0	0	0.00361	0	67	137										C	234669219	G	C	234669219	3	2	43	1	0	0	0	0	1	0	0	0	16941	1116	39	4	288	4	UGT1A1	2	234669219	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	32909209	234669219	8530154	42	11149										
UGT1A1	54658	broad.mit.edu	37	chr2	234669236	234669236	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctcgggcataatgtttttgaGaatgattctttcctgcagcg	10	8	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:234669236G>T	uc002vvb.2	+	1	318	c.303G>T	c.(301-303)GAG>GAT	p.E101D	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Missense_Mutation_p.E101D	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	101					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	ATGTTTTTGAGAATGATTCTT	0.423													1	0	1.7318e-42	0.00361	1.96312e-42	98	83										T	234669236	G	T	234669236	3	4	43	1	0	0	0	0	1	0	0	0	16941	933	33	3	305	3	UGT1A1	2	234669236	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	17	234669236	8530137	43	11150										
RBM44	375316	broad.mit.edu	37	chr2	238726935	238726943	+	In_Frame_Del	DEL	CAAGTTGTA	CAAGTTGTA	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	taaatcattgacagatgcagCaagttgtacagtcacaatta							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr2:238726935_238726943delCAAGTTGTA	uc002vxi.3	+	3	1508_1516	c.1376_1384delCAAGTTGTA	c.(1375-1386)GCAAGTTGTACA>GCA	p.SCT460del		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	459_461							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		ACAGATGCAGCAAGTTGTACAGTCACAAT	0.397																		24	65	---	---								-	238726943	CAAGTTGTA	-	238726935	7	5	43	1	0	1	0	1	0	0	0	0	13138	710	25	0	1382	0	RBM44	2	238726935	In_Frame_Del	DEL	CAAGTTGTA	TCGA-DK-A1A7-01A-11D-A13W-08	4057699	238726935	4472438	44	11151										
TMEM111	55831	broad.mit.edu	37	chr3	10012301	10012301	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaatcagagagtaaatgctcCgaagcccaaatacattgagg	10	8	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:10012301C>G	uc003bun.2	-	6	718	c.539G>C	c.(538-540)CGG>CCG	p.R180P	CIDEC_uc003bto.2_Intron|TMEM111_uc003buo.2_Missense_Mutation_p.R180P	NM_018447	NP_060917	Q9P0I2	TM111_HUMAN	transmembrane protein 111	180						integral to membrane					0						GTAAATGCTCCGAAGCCCAAA	0.403													0	0	0	0.00361	0	206	82										G	10012301	C	G	10012301	3	3	43	1	0	0	0	0	1	0	0	0	16025	652	23	4	258	4	TMEM111	3	10012301	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		10012301	188010129	45	11152										
NR2C2	7182	broad.mit.edu	37	chr3	15062406	15062406	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gctgtcagttttgccggctgAaaaaatgcttagagatgggc	13	7	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:15062406A>G	uc003bzj.3	+	5	740	c.523A>G	c.(523-525)AAA>GAA	p.K175E	NR2C2_uc003bzi.2_Missense_Mutation_p.K194E	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	175	NR C4-type.|Nuclear receptor.				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						TTGCCGGCTGAAAAAATGCTT	0.408													0	0	0	0.00499	0	14	44										G	15062406	A	G	15062406	3	3	43	1	0	0	0	0	1	0	0	0	10623	247	9	5	598	5	NR2C2	3	15062406	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	5050105	15062406	182960024	46	11153										
ANKRD28	23243	broad.mit.edu	37	chr3	15762530	15762530	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aatcctttttcattcttttgAttcacaatagcaccacagtc	3	11	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:15762530A>T	uc003caj.1	-	8	941	c.798T>A	c.(796-798)AAT>AAA	p.N266K	ANKRD28_uc003cai.1_Missense_Mutation_p.N112K|ANKRD28_uc011avz.1_Missense_Mutation_p.N112K|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.N296K|ANKRD28_uc003cam.2_Missense_Mutation_p.N299K	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	266	ANK 7.					nucleoplasm	protein binding			breast(1)	1						CATTCTTTTGATTCACAATAG	0.403													0	0	0	0.00361	0	94	212										T	15762530	A	T	15762530	3	4	43	1	0	0	0	0	1	0	0	0	656	330	12	5	2447	5	ANKRD28	3	15762530	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	700124	15762530	182259900	47	11154										
KCNH8	131096	broad.mit.edu	37	chr3	19575409	19575409	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctttgcacctagttctcccaAgcagatcagaggagggcagc	11	12	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:19575409A>C	uc003cbk.1	+	16	3337	c.3142A>C	c.(3142-3144)AGC>CGC	p.S1048R	KCNH8_uc010hex.1_Missense_Mutation_p.S509R	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	1048	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AGTTCTCCCAAGCAGATCAGA	0.488													0	0	0	0.00361	0	56	56										C	19575409	A	C	19575409	3	2	43	1	0	0	0	0	1	0	0	0	8038	72	3	5	3204	5	KCNH8	3	19575409	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	3812879	19575409	178447021	48	11155										
EXOG	9941	broad.mit.edu	37	chr3	38537926	38537926	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tctgagcggcttcgtggctgGggctgtagtgggcgctgcgg	20	9	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:38537926G>A	uc003cih.2	+	1	164	c.68G>A	c.(67-69)GGG>GAG	p.G23E	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Missense_Mutation_p.G23E|EXOG_uc003cij.2_5'UTR|EXOG_uc010hhd.2_5'UTR|EXOG_uc010hhe.2_5'UTR|EXOG_uc003cik.2_5'UTR|EXOG_uc010hhf.2_5'UTR|EXOG_uc003cii.2_5'UTR	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	23						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						TTCGTGGCTGGGGCTGTAGTG	0.652											OREG0015479	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	3	12										A	38537926	G	A	38537926	3	1	43	1	0	0	0	0	1	0	0	0	5312	1232	43	2	70	2	EXOG	3	38537926	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	18962517	38537926	159484504	49	11156										
NKTR	4820	broad.mit.edu	37	chr3	42687412	42687412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttatggctctgacagtgaaaGtgaccgaagttactctcatc	9	9	2	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:42687412G>A	uc003clo.2	+	17	4481	c.4334G>A	c.(4333-4335)AGT>AAT	p.S1445N	NKTR_uc003clp.2_Missense_Mutation_p.S1193N|NKTR_uc011azp.1_Missense_Mutation_p.V256M|NKTR_uc003cls.2_Missense_Mutation_p.S1145N	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1445					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GACAGTGAAAGTGACCGAAGT	0.353													0	0	0	0.006214	0	9	19										A	42687412	G	A	42687412	3	1	43	1	0	0	0	0	1	0	0	0	10448	1029	36	2	4396	2	NKTR	3	42687412	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	4149486	42687412	155335018	50	11157										
SETD2	29072	broad.mit.edu	37	chr3	47125299	47125299	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttcttggctcctttcactctCcacatcagacacaccctcct	3	18	4	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	RNASeq;WGS			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:47125299C>A	uc003cqs.2	-	12	6024	c.5971G>T	c.(5971-5973)GAG>TAG	p.E1991*	SETD2_uc003cqv.2_Nonsense_Mutation_p.E2058*|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1991					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTTTCACTCTCCACATCAGAC	0.448			N|F|S|Mis		clear cell renal carcinoma								1	0	4.09166e-32	0.00361	4.62151e-32	70	80										A	47125299	C	A	47125299	4	1	43	1	0	0	0	0	0	1	0	0	14131	864	30	3	1763	3	SETD2	3	47125299	Nonsense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	4437887	47125299	150897131	51	11158										
CCDC51	79714	broad.mit.edu	37	chr3	48474335	48474335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cctcttggagactcacaggcCccttctgcgcctccaggagt	10	16	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:48474335C>T	uc003csz.2	-	4	840	c.719G>A	c.(718-720)GGG>GAG	p.G240E	PLXNB1_uc003csx.2_5'Flank|CCDC51_uc003cta.2_Missense_Mutation_p.G131E|CCDC51_uc003ctb.2_Missense_Mutation_p.G131E|CCDC51_uc003ctc.2_Missense_Mutation_p.G240E|CCDC51_uc003ctd.2_Missense_Mutation_p.G131E	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	240						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ACTCACAGGCCCCTTCTGCGC	0.602													0	0	0	0.009718	0	39	42										T	48474335	C	T	48474335	3	4	43	1	0	0	0	0	1	0	0	0	2821	623	22	2	520	2	CCDC51	3	48474335	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	1349036	48474335	149548095	52	11159										
WDR6	11180	broad.mit.edu	37	chr3	49051674	49051674	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttgctgtgtgtgaacttgacCagcccggccttggccccctt	11	14	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:49051674C>T	uc003cvj.2	+	3	2842	c.2704C>T	c.(2704-2706)CAG>TAG	p.Q902*	WDR6_uc011bby.1_Nonsense_Mutation_p.Q350*|WDR6_uc010hkn.2_Nonsense_Mutation_p.Q846*|WDR6_uc011bbz.1_Nonsense_Mutation_p.Q821*	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	872	WD 13.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGAACTTGACCAGCCCGGCCT	0.582											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	6	30										T	49051674	C	T	49051674	4	4	43	1	0	0	0	0	0	1	0	0	17307	595	21	2	2714	2	WDR6	3	49051674	Nonsense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	577339	49051674	148970756	53	11160										
USP19	10869	broad.mit.edu	37	chr3	49153998	49153998	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aatccgggcccttctcatacGagtcattcttgacaaacgcc	7	14	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:49153998G>A	uc003cwd.1	-	7	1027	c.866C>T	c.(865-867)TCG>TTG	p.S289L	USP19_uc003cwa.2_Missense_Mutation_p.S95L|USP19_uc003cvz.3_Missense_Mutation_p.S390L|USP19_uc011bcg.1_Missense_Mutation_p.S380L|USP19_uc003cwb.2_Missense_Mutation_p.S375L|USP19_uc003cwc.1_Missense_Mutation_p.S45L|USP19_uc011bch.1_Missense_Mutation_p.S390L|USP19_uc011bci.1_Missense_Mutation_p.S375L	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	289	CS 2.|Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTTCTCATACGAGTCATTCTT	0.537													0	0	0	0.010771	0	42	50										A	49153998	G	A	49153998	3	1	43	1	0	0	0	0	1	0	0	0	17047	1059	37	1	3170	1	USP19	3	49153998	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	102324	49153998	148868432	54	11161										
MST1R	4486	broad.mit.edu	37	chr3	49929204	49929204	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cacttacgacttagtgacttGatggcacattggattcgatt	9	8	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:49929204G>C	uc003cxy.3	-	15	3603	c.3339C>G	c.(3337-3339)ATC>ATG	p.I1113M	MST1R_uc011bdc.1_Translation_Start_Site	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1113	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TTAGTGACTTGATGGCACATT	0.517													0	0	0	0.00361	0	84	79										C	49929204	G	C	49929204	3	2	43	1	0	0	0	0	1	0	0	0	9891	1280	45	1	887	1	MST1R	3	49929204	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	775206	49929204	148093226	55	11162										
ITIH3	3699	broad.mit.edu	37	chr3	52835110	52835110	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaacatggccctggagaaccAtgggtttgcccggcgcattt	13	11	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:52835110A>G	uc003dfv.2	+	11	1367	c.1331A>G	c.(1330-1332)CAT>CGT	p.H444R	ITIH3_uc011bek.1_Missense_Mutation_p.H444R	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	444	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CTGGAGAACCATGGGTTTGCC	0.393													0	0	0	0.008871	0	21	21										G	52835110	A	G	52835110	3	3	43	1	0	0	0	0	1	0	0	0	7905	217	8	5	1373	5	ITIH3	3	52835110	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2905906	52835110	145187320	56	11163										
CACNA2D3	55799	broad.mit.edu	37	chr3	54420796	54420796	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aacatgaatttgatgcagacTtacaggtaactgattatagt	8	5	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:54420796T>A	uc003dhf.2	+	4	424	c.376T>A	c.(376-378)TTA>ATA	p.L126I	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.L32I|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_5'UTR	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	126	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGATGCAGACTTACAGGTAAC	0.368													0	0	0	0.009096	0	3	9										A	54420796	T	A	54420796	3	1	43	1	0	0	0	0	1	0	0	0	2550	1606	56	5	390	5	CACNA2D3	3	54420796	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	1585686	54420796	143601634	57	11164										
WNT5A	7474	broad.mit.edu	37	chr3	55504170	55504170	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgtgcacttcttgcacttgaCgtagcagcaccagtggaact	10	12	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:55504170C>G	uc003dhn.2	-	5	1411	c.1093G>C	c.(1093-1095)GTC>CTC	p.V365L	WNT5A_uc003dhm.2_Missense_Mutation_p.V350L|WNT5A_uc010hmw.2_Missense_Mutation_p.V350L|WNT5A_uc010hmx.2_Missense_Mutation_p.V276L	NM_003392	NP_003383	P41221	WNT5A_HUMAN	wingless-type MMTV integration site family,	365					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)		TTGCACTTGACGTAGCAGCAC	0.592													0	0	0	0.007291	0	22	30										G	55504170	C	G	55504170	3	3	43	1	0	0	0	0	1	0	0	0	17388	536	19	4	53	4	WNT5A	3	55504170	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	1083374	55504170	142518260	58	11165										
KIAA1524	57650	broad.mit.edu	37	chr3	108273235	108273235	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gattttacttttcattttgtTccttgagtgactcattcaac	5	8	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:108273235T>A	uc003dxb.3	-	18	2581	c.2312A>T	c.(2311-2313)GAA>GTA	p.E771V		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	771	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTCATTTTGTTCCTTGAGTGA	0.269													0	0	0	0.001984	0	5	12										A	108273235	T	A	108273235	3	1	43	1	0	0	0	0	1	0	0	0	8239	1783	62	5	421	5	KIAA1524	3	108273235	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	52769065	108273235	89749195	59	11166										
CASR	846	broad.mit.edu	37	chr3	121994736	121994736	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttgatgagtgtggtgacctGgtggggaactattccatcat	13	6	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:121994736G>C	uc003eev.3	+	5	1827	c.1455G>C	c.(1453-1455)CTG>CTC	p.L485L	CASR_uc003eew.3_Silent_p.L485L	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	485	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GTGGTGACCTGGTGGGGAACT	0.488													0	0	0	0.00361	0	63	96										C	121994736	G	C	121994736	2	2	43	1	0	0	0	0	0	0	0	1	2682	1335	47	4		4	CASR	3	121994736	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	13721501	121994736	76027694	60	11167										
ADCY5	111	broad.mit.edu	37	chr3	123046525	123046525	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctgtgctccttgaggtaggcGttgcgctcgcccccacagcc	12	16	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:123046525G>A	uc003egh.1	-	7	1887	c.1887C>T	c.(1885-1887)AAC>AAT	p.N629N	ADCY5_uc003egg.1_Silent_p.N262N|ADCY5_uc003egi.1_Silent_p.N188N	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	629	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGAGGTAGGCGTTGCGCTCGC	0.642													0	0	0	0.00308	0	8	33										A	123046525	G	A	123046525	2	1	43	1	0	0	0	0	0	0	0	1	297	1136	40	2		2	ADCY5	3	123046525	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1051789	123046525	74975905	61	11168										
STAG1	10274	broad.mit.edu	37	chr3	136287647	136287647	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ataaaaaagttgattaaatcCagaagtgcgatgtccctgtc	8	7	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:136287647C>T	uc003era.1	-	5	646	c.354G>A	c.(352-354)CTG>CTA	p.L118L	STAG1_uc003erb.1_Silent_p.L118L|STAG1_uc003erc.1_5'UTR|STAG1_uc010hua.1_5'UTR|STAG1_uc003erd.2_Silent_p.L21L|STAG1_uc003ere.2_Silent_p.L118L	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	118					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						TGATTAAATCCAGAAGTGCGA	0.353													0	0	0	0.004007	0	14	44										T	136287647	C	T	136287647	2	4	43	1	0	0	0	0	0	0	0	1	15241	581	21	2		2	STAG1	3	136287647	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	13241122	136287647	61734783	62	11169										
MRPS22	56945	broad.mit.edu	37	chr3	139065815	139065815	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caggcttgaacttgcagaagActtttaagccagctatacaa	8	9	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:139065815A>T	uc003etb.2	+	2	276	c.268A>T	c.(268-270)ACT>TCT	p.T90S	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.T89S|MRPS22_uc003ete.2_Missense_Mutation_p.T49S	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	90						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						CTTGCAGAAGACTTTTAAGCC	0.413													0	0	0	0.00361	0	55	70										T	139065815	A	T	139065815	3	4	43	1	0	0	0	0	1	0	0	0	9833	275	10	5	274	5	MRPS22	3	139065815	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2778168	139065815	58956615	63	11170										
TFDP2	7029	broad.mit.edu	37	chr3	141671502	141671502	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggaactgcccagttgctaaGgccacttctgcatccaagca	9	13	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:141671502G>C	uc003eun.3	-	13	1573	c.1194C>G	c.(1192-1194)GCC>GCG	p.A398A	TFDP2_uc003euk.3_Silent_p.A311A|TFDP2_uc010hur.2_Silent_p.A338A|TFDP2_uc003eul.3_Silent_p.A338A|TFDP2_uc011bnf.1_Silent_p.A301A|TFDP2_uc011bng.1_Silent_p.A262A|TFDP2_uc003eum.3_Silent_p.A338A	NM_006286	NP_006277	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization	398					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1						CAGTTGCTAAGGCCACTTCTG	0.493													0	0	0	0.002836	0	32	42										C	141671502	G	C	141671502	2	2	43	1	0	0	0	0	0	0	0	1	15795	987	35	4		4	TFDP2	3	141671502	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2605687	141671502	56350928	64	11171										
TRPC1	7220	broad.mit.edu	37	chr3	142499680	142499680	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atgctgcattttataggaatGattatgaggaactagcccgg	11	6	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:142499680G>A	uc003evc.2	+	6	905	c.769G>A	c.(769-771)GAT>AAT	p.D257N	TRPC1_uc003evb.2_Missense_Mutation_p.D223N	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	257	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TTATAGGAATGATTATGAGGA	0.343													0	0	0	0.003163	0	15	61										A	142499680	G	A	142499680	3	1	43	1	0	0	0	0	1	0	0	0	16575	1290	45	1	685	1	TRPC1	3	142499680	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	828178	142499680	55522750	65	11172										
P2RY13	53829	broad.mit.edu	37	chr3	151046556	151046556	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcagagaggattttgaaaggAagcatgagtgtcattatcaa	11	4	3	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:151046556A>G	uc003eyv.2	-	2	309	c.288T>C	c.(286-288)CTT>CTC	p.L96L	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	96	Helical; Name=2; (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			TTTTGAAAGGAAGCATGAGTG	0.468													0	0	0	0.012213	0	34	55										G	151046556	A	G	151046556	2	3	43	1	0	0	0	0	0	0	0	1	11350	233	9	5		5	P2RY13	3	151046556	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	8546876	151046556	46975874	66	11173										
GP5	2814	broad.mit.edu	37	chr3	194117570	194117570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggagctgtccgcagcggggCggggaggcgggccccggggg	24	11	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr3:194117570C>T	uc003ftv.1	-	2	1473	c.1442G>A	c.(1441-1443)CGC>CAC	p.R481H		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	481	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CGCAgcggggcggggaggcgg	0.612													0	0	0	0.008361	0	32	36										T	194117570	C	T	194117570	3	4	43	1	0	0	0	0	1	0	0	0	6583	768	27	2	244	2	GP5	3	194117570	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	43071014	194117570	3904860	67	11174										
DRD5	1816	broad.mit.edu	37	chr4	9784901	9784901	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tacatccacatgatgcccaaCgccgttacccccggcaaccg	7	18	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:9784901C>T	uc003gmb.3	+	1	1644	c.1248C>T	c.(1246-1248)AAC>AAT	p.N416N		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	416	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	TGATGCCCAACGCCGTTACCC	0.562													0	0	0	0.002299	0	20	42										T	9784901	C	T	9784901	2	4	43	1	0	0	0	0	0	0	0	1	4760	535	19	2		2	DRD5	4	9784901	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		9784901	181369375	68	11175										
PHOX2B	8929	broad.mit.edu	37	chr4	41748140	41748140	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgccgccgccgcctccattcGccccgcagctgggggtgggg	16	18	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:41748140G>A	uc003gwf.3	-	3	989	c.629C>T	c.(628-630)GCG>GTG	p.A210V		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	210					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						gccTCCATTCGCCCCGCAGCT	0.408			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.001984	0	7	16										A	41748140	G	A	41748140	3	1	43	1	0	0	0	0	1	0	0	0	11859	1087	38	2	319	2	PHOX2B	4	41748140	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	31963239	41748140	149406136	69	11176										
NMU	10874	broad.mit.edu	37	chr4	56471508	56471508	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agctgcagcaacggatgcacAactgacgactgagaggacat	12	10	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:56471508A>C	uc003hbc.2	-	7	475	c.369T>G	c.(367-369)GTT>GTG	p.V123V	NMU_uc003hbd.1_Intron|NMU_uc010igv.1_RNA|NMU_uc010igw.1_Silent_p.V38V|NMU_uc010igx.1_Intron	NM_006681	NP_006672	P48645	NMU_HUMAN	neuromedin U precursor	123					neuropeptide signaling pathway	extracellular region					0	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		ACGGATGCACAACTGACGACT	0.463													0	0	0	0.008361	0	29	27										C	56471508	A	C	56471508	2	2	43	1	0	0	0	0	0	0	0	1	10505	117	5	5		5	NMU	4	56471508	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	14723368	56471508	134682768	70	11177										
PDE5A	8654	broad.mit.edu	37	chr4	120484008	120484008	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggagcaatcttcatccactaTgaaaatggtgcatttctgca	8	9	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:120484008T>C	uc003idh.2	-	6	1266	c.1111A>G	c.(1111-1113)ATA>GTA	p.I371V	PDE5A_uc003idf.2_Missense_Mutation_p.I329V|PDE5A_uc003idg.2_Missense_Mutation_p.I319V	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	371	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	TCATCCACTATGAAAATGGTG	0.299													0	0	0	0.005443	0	23	64										C	120484008	T	C	120484008	3	2	43	1	0	0	0	0	1	0	0	0	11644	1464	51	5	1580	5	PDE5A	4	120484008	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	64012500	120484008	70670268	71	11178										
C4orf31	79625	broad.mit.edu	37	chr4	121958158	121958158	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tacctacataagcggtgctcAtgttgctgttgatgttgacc	10	9	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:121958158A>C	uc003idq.1	-	4	1495	c.968T>G	c.(967-969)ATG>AGG	p.M323R		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	323	Fibronectin type-III 1.										0						AGCGGTGCTCATGTTGCTGTT	0.418													0	0	0	0.00632	0	29	46										C	121958158	A	C	121958158	3	2	43	1	0	0	0	0	1	0	0	0	2261	217	8	5	742	5	C4orf31	4	121958158	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	1474150	121958158	69196118	72	11179										
PCDH10	57575	broad.mit.edu	37	chr4	134071562	134071562	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caaatctgcaaacagagcccCtcctgtgtcctgcacctgga	8	15	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:134071562C>A	uc003iha.2	+	1	1093	c.267C>A	c.(265-267)CCC>CCA	p.P89P	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.P89P	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	89	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AACAGAGCCCCTCCTGTGTCC	0.547													1	0	5.35047e-06	0.00333	5.60016e-06	25	42										A	134071562	C	A	134071562	2	1	43	1	0	0	0	0	0	0	0	1	11507	668	24	4		4	PCDH10	4	134071562	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	12113404	134071562	57082714	73	11180										
USP38	84640	broad.mit.edu	37	chr4	144127185	144127185	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttcttctttatgacctataGgattttcctaagcccagtga	6	9	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:144127185G>A	uc003ijb.2	+	6	1744	c.1210_splice	c.e6-1	p.D404_splice	USP38_uc003ija.3_Splice_Site_p.D404_splice|USP38_uc003ijc.2_Splice_Site	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					ATGACCTATAGGATTTTCCTA	0.308													0	0	0	0.010504	0	20	29										A	144127185	G	A	144127185	5	1	43	1	0	0	0	0	0	0	1	0	17066	1014	35	2	1231	2	USP38	4	144127185	Splice_Site	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	10055623	144127185	47027091	74	11181										
NPY5R	4889	broad.mit.edu	37	chr4	164271624	164271624	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tacttattttaatggctctcAtgaaaaagcgtaatcagaag	7	6	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr4:164271624A>G	uc003iqn.2	+	4	381	c.199A>G	c.(199-201)ATG>GTG	p.M67V		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	67	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				AATGGCTCTCATGAAAAAGCG	0.383													0	0	0	0.00361	0	56	129										G	164271624	A	G	164271624	3	3	43	1	0	0	0	0	1	0	0	0	10610	217	8	5	201	5	NPY5R	4	164271624	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	20144439	164271624	26882652	75	11182										
ADCY2	108	broad.mit.edu	37	chr5	7817004	7817004	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgagcggcagtacatgcacaTtggcaccatggtggagtttg	14	9	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:7817004T>C	uc003jdz.1	+	23	2976	c.2909T>C	c.(2908-2910)ATT>ACT	p.I970T	ADCY2_uc011cmo.1_Missense_Mutation_p.I790T|ADCY2_uc010itm.1_Missense_Mutation_p.I166T	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	970	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TACATGCACATTGGCACCATG	0.517											OREG0016499	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.002299	0	21	57										C	7817004	T	C	7817004	3	2	43	1	0	0	0	0	1	0	0	0	294	1493	52	5	2999	5	ADCY2	5	7817004	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08		7817004	173098256	76	11183										
TRIO	7204	broad.mit.edu	37	chr5	14492807	14492807	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gccagcaaccagcagaacatGtttctggtgttccgagccgc	11	13	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:14492807G>A	uc003jff.2	+	49	7770	c.7764G>A	c.(7762-7764)ATG>ATA	p.M2588I	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2588	SH3 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGCAGAACATGTTTCTGGTGT	0.562													0	0	0	0.001168	0	5	24										A	14492807	G	A	14492807	3	1	43	1	0	0	0	0	1	0	0	0	16549	1377	48	2	7958	2	TRIO	5	14492807	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	6675803	14492807	166422453	77	11184										
ADAMTS12	81792	broad.mit.edu	37	chr5	33576343	33576343	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcaggtggttacggtttgccGtctttcctgagggttctggc	14	9	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:33576343G>A	uc003jia.1	-	19	3951	c.3788C>T	c.(3787-3789)ACG>ATG	p.T1263M	ADAMTS12_uc010iuq.1_Missense_Mutation_p.T1178M	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1263	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACGGTTTGCCGTCTTTCCTGA	0.502										HNSCC(64;0.19)			0	0	0	0.00361	0	48	92										A	33576343	G	A	33576343	3	1	43	1	0	0	0	0	1	0	0	0	257	1145	40	2	1020	2	ADAMTS12	5	33576343	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	19083536	33576343	147338917	78	11185										
NIPBL	25836	broad.mit.edu	37	chr5	36976326	36976326	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caagtgcctgttttacaacaGaacacttcagttgctgcaaa	7	10	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:36976326G>C	uc003jkl.3	+	9	1816	c.1317G>C	c.(1315-1317)CAG>CAC	p.Q439H	NIPBL_uc003jkk.3_Missense_Mutation_p.Q439H|NIPBL_uc003jkm.1_Missense_Mutation_p.Q318H	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	439	Gln-rich.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTTTACAACAGAACACTTCAG	0.423													0	0	0	0.010504	0	22	46										C	36976326	G	C	36976326	3	2	43	1	0	0	0	0	1	0	0	0	10428	933	33	1	1347	1	NIPBL	5	36976326	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	3399983	36976326	143938934	79	11186										
MAP3K1	4214	broad.mit.edu	37	chr5	56152428	56152428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtttctgcctgcattttagtCgtgagatggagaataaagaa	11	5	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:56152428C>T	uc003jqw.3	+	2	985	c.484C>T	c.(484-486)CGT>TGT	p.R162C		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	162					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GCATTTTAGTCGTGAGATGGA	0.373													0	0	0	0.008291	0	11	12										T	56152428	C	T	56152428	3	4	43	1	0	0	0	0	1	0	0	0	9243	898	31	1	490	1	MAP3K1	5	56152428	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	19176102	56152428	124762832	80	11187										
TNPO1	3842	broad.mit.edu	37	chr5	72144225	72144225	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttgcagcaaaccaagatggAgtatgagtggaaacctgacg	12	7	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:72144225A>C	uc003kck.3	+	2	176	c.29A>C	c.(28-30)GAG>GCG	p.E10A	TNPO1_uc011csi.1_RNA|TNPO1_uc011csj.1_Missense_Mutation_p.E10A|TNPO1_uc003kch.2_Missense_Mutation_p.E2A|TNPO1_uc003kci.3_Missense_Mutation_p.E2A|TNPO1_uc003kcg.3_Missense_Mutation_p.E2A	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	10					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		ACCAAGATGGAGTATGAGTGG	0.562													0	0	0	0.007413	0	19	5										C	72144225	A	C	72144225	3	2	43	1	0	0	0	0	1	0	0	0	16332	304	11	5	35	5	TNPO1	5	72144225	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	15991797	72144225	108771035	81	11188										
WDR36	134430	broad.mit.edu	37	chr5	110459882	110459882	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgaagaaggactggtaaataAtaagtgtaagttgaattata	10	1	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:110459882A>T	uc003kpd.2	+	21	2630	c.2513A>T	c.(2512-2514)AAT>ATT	p.N838I	WDR36_uc010jbu.2_Intron	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	838					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CTGGTAAATAATAAGTGTAAG	0.279													0	0	0	0.004007	0	14	77										T	110459882	A	T	110459882	3	4	43	1	0	0	0	0	1	0	0	0	17287	101	4	5	2595	5	WDR36	5	110459882	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	38315657	110459882	70455378	82	11189										
SEMA6A	57556	broad.mit.edu	37	chr5	115833065	115833065	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtgtgtgatgtgtctatatcAacagtataaatatggtccct	9	6	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:115833065A>T	uc010jck.2	-	4	946	c.237T>A	c.(235-237)GTT>GTA	p.V79V	SEMA6A_uc003krx.3_Silent_p.V79V	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	79	Sema.|Extracellular (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGTCTATATCAACAGTATAAA	0.303													0	0	0	0.001168	0	5	53										T	115833065	A	T	115833065	2	4	43	1	0	0	0	0	0	0	0	1	14039	117	5	5		5	SEMA6A	5	115833065	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	5373183	115833065	65082195	83	11190										
HSD17B4	3295	broad.mit.edu	37	chr5	118865646	118865646	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atgtggatcttgcaccaacaTctggtacttcagctaagaca	8	10	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:118865646T>C	uc003ksj.2	+	21	1948	c.1825T>C	c.(1825-1827)TCT>CCT	p.S609P	HSD17B4_uc011cwg.1_Missense_Mutation_p.S585P|HSD17B4_uc011cwh.1_Missense_Mutation_p.S591P|HSD17B4_uc011cwi.1_Missense_Mutation_p.S634P|HSD17B4_uc003ksk.3_Missense_Mutation_p.S462P|HSD17B4_uc011cwj.1_Missense_Mutation_p.S462P|HSD17B4_uc010jcn.1_Missense_Mutation_p.S347P|HSD17B4_uc010jco.1_Silent_p.H77H	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	609	Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	TGCACCAACATCTGGTACTTC	0.363													0	0	0	0.012319	0	22	128										C	118865646	T	C	118865646	3	2	43	1	0	0	0	0	1	0	0	0	7386	1435	50	5	1907	5	HSD17B4	5	118865646	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	3032581	118865646	62049614	84	11191										
MATR3	9782	broad.mit.edu	37	chr5	138654644	138654644	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gatgctcaggccgcagtggaTtattacacaaccacaccagc	9	13	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:138654644T>C	uc003ldu.2	+	11	1783	c.1356T>C	c.(1354-1356)GAT>GAC	p.D452D	MATR3_uc010jfb.2_Silent_p.D452D|MATR3_uc003ldt.2_Silent_p.D114D|MATR3_uc003ldw.2_Silent_p.D452D|MATR3_uc003ldx.2_Silent_p.D452D|MATR3_uc010jfc.2_Silent_p.D452D|MATR3_uc003ldy.2_Silent_p.D129D|MATR3_uc011czb.1_Silent_p.D164D|MATR3_uc003ldz.2_Silent_p.D452D|MATR3_uc003lea.2_Silent_p.D452D|MATR3_uc003leb.2_Silent_p.D114D|MATR3_uc003lec.2_Silent_p.D129D	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	452	RRM 1.					nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCGCAGTGGATTATTACACAA	0.363													0	0	0	0.00245	0	15	36										C	138654644	T	C	138654644	2	2	43	1	0	0	0	0	0	0	0	1	9337	1490	52	5		5	MATR3	5	138654644	Silent	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	19788998	138654644	42260616	85	11192										
C5orf53	492311	broad.mit.edu	37	chr5	139508200	139508200	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgttgtgcatcagccggcttGagtttgttcaatatcaaagc	10	8	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:139508200G>A	uc003lfb.1	+	1	2680	c.139G>A	c.(139-141)GAG>AAG	p.E47K		NM_001007189	NP_001007190	A6NJ69	IGIP_HUMAN	IgA-inducing protein precursor	47						extracellular region					0						CAGCCGGCTTGAGTTTGTTCA	0.393													0	0	0	0.010504	0	21	67										A	139508200	G	A	139508200	3	1	43	1	0	0	0	0	1	0	0	0	2309	1291	45	1	141	1	C5orf53	5	139508200	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	853556	139508200	41407060	86	11193										
PCDHA4	56144	broad.mit.edu	37	chr5	140186836	140186836	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgctcttacttcttctcctcGcagcctgggaggcagggaac	11	13	3	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:140186836G>A	uc003lhi.2	+	1	165	c.64G>A	c.(64-66)GCA>ACA	p.A22T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A22T|PCDHA4_uc011daa.1_Missense_Mutation_p.A22T	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	22					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCTCCTCGCAGCCTGGGA	0.572													0	0	0	0.009535	0	31	96										A	140186836	G	A	140186836	3	1	43	1	0	0	0	0	1	0	0	0	11526	1087	38	2	66	2	PCDHA4	5	140186836	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	678636	140186836	40728424	87	11194										
KCTD16	57528	broad.mit.edu	37	chr5	143586786	143586786	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggtttcattactgtgggttAcagaggatcctgcaccttgg	13	8	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:143586786A>G	uc003lnm.1	+	3	1138	c.509A>G	c.(508-510)TAC>TGC	p.Y170C	KCTD16_uc003lnn.1_Missense_Mutation_p.Y170C	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	170						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			ACTGTGGGTTACAGAGGATCC	0.537													0	0	0	0.003755	0	36	28										G	143586786	A	G	143586786	3	3	43	1	0	0	0	0	1	0	0	0	8103	391	14	5	511	5	KCTD16	5	143586786	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	3399950	143586786	37328474	88	11195										
HK3	3101	broad.mit.edu	37	chr5	176308405	176308406	+	Frame_Shift_Ins	INS	-	-	C													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caccacggcagctacacccgINSccccacagagctgggcagcc					rs145283059		TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:176308405_176308406insC	uc003mfa.2	-	18	2616_2617	c.2524_2525insG	c.(2524-2526)GCGfs	p.A842fs	HK3_uc003mez.2_Frame_Shift_Ins_p.A398fs	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	842	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTACACCCGCCCCACAGAGC	0.639																		24	29	---	---								C	176308406	-	C	176308405	7	5	43	1	0	1	1	0	0	0	0	0	7192	1087	38	0	254	0	HK3	5	176308405	Frame_Shift_Ins	INS	-	TCGA-DK-A1A7-01A-11D-A13W-08	32721619	176308405	4606855	89	11196										
NSD1	64324	broad.mit.edu	37	chr5	176707662	176707662	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctgatgagaacccctgtgggAtagactctgaatgcatcaac	10	10	2	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	WGS			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:176707662A>G	uc003mfr.3	+	18	5857	c.5719A>G	c.(5719-5721)ATA>GTA	p.I1907V	NSD1_uc003mft.3_Missense_Mutation_p.I1638V|NSD1_uc003mfs.1_Missense_Mutation_p.I1804V|NSD1_uc011dfx.1_Missense_Mutation_p.I1555V	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1907	AWS.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCCCTGTGGGATAGACTCTGA	0.522			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.003271	0	35	37										G	176707662	A	G	176707662	3	3	43	1	0	0	0	0	1	0	0	0	10669	333	12	5	5785	5	NSD1	5	176707662	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	399257	176707662	4207598	90	11197										
B4GALT7	11285	broad.mit.edu	37	chr5	177034458	177034458	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccacgtggcctccccggagcTccaccctctctaccactaca	6	21	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:177034458T>G	uc003mhy.2	+	3	609	c.569T>G	c.(568-570)CTC>CGC	p.L190R	B4GALT7_uc003mhz.2_Missense_Mutation_p.L76R	NM_007255	NP_009186	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase 7	190	Lumenal (Potential).				fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			pancreas(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCCCGGAGCTCCACCCTCTC	0.617											OREG0017092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	27										G	177034458	T	G	177034458	3	3	43	1	0	0	0	0	1	0	0	0	1276	1551	54	5	579	5	B4GALT7	5	177034458	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	326796	177034458	3880802	91	11198										
HNRNPAB	3182	broad.mit.edu	37	chr5	177637274	177637274	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cggccccggctacgactacaGtaagtaggagagagggaggc	16	10	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr5:177637274G>A	uc003miu.2	+	7	1185	c.928_splice	c.e7+1	p.S310_splice	HNRNPAB_uc003miv.2_Intron|HNRNPAB_uc010jks.2_Intron|HNRNPAB_uc003miw.2_Splice_Site_p.S310_splice|HNRNPAB_uc003mix.2_Intron|AGXT2L2_uc003miy.2_Intron|AGXT2L2_uc003mjc.2_Intron|AGXT2L2_uc003miz.2_Intron|AGXT2L2_uc003mja.2_Intron|AGXT2L2_uc003mjb.2_Intron	NM_031266	NP_112556	Q99729	ROAA_HUMAN	heterogeneous nuclear ribonucleoprotein A/B						epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0						TACGACTACAGTAAGTAGGAG	0.567													0	0	0	0.001368	0	10	6										A	177637274	G	A	177637274	5	1	43	1	0	0	0	0	0	0	1	0	7261	1043	36	2	951	2	HNRNPAB	5	177637274	Splice_Site	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	602816	177637274	3277986	92	11199										
HIST1H3A	8350	broad.mit.edu	37	chr6	26020953	26020953	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gcgcgagattgcgcaggactTtaaaacagacctgcgtttcc	11	11	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:26020953T>G	uc003nfp.1	+	1	236	c.236T>G	c.(235-237)TTT>TGT	p.F79C	HIST1H1A_uc003nfo.2_5'Flank|HIST1H4A_uc003nfq.2_5'Flank	NM_003529	NP_003520	P68431	H31_HUMAN	histone cluster 1, H3a	79					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)|pancreas(1)	2						GCGCAGGACTTTAAAACAGAC	0.562													0	0	0	0.006122	0	13	25										G	26020953	T	G	26020953	3	3	43	1	0	0	0	0	1	0	0	0	7155	1841	64	5	238	5	HIST1H3A	6	26020953	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08		26020953	145094114	93	11200										
SLC44A4	80736	broad.mit.edu	37	chr6	31831441	31831441	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgttgtccgggggcgcctcgTtcttcttgcccagaatcttt	11	12	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:31831441T>A	uc010jti.2	-	21	2162	c.2096A>T	c.(2095-2097)AAC>ATC	p.N699I	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	699	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GGGCGCCTCGTTCTTCTTGCC	0.597													0	0	0	0.003163	0	15	22										A	31831441	T	A	31831441	3	1	43	1	0	0	0	0	1	0	0	0	14638	1725	60	5	40	5	SLC44A4	6	31831441	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	5810488	31831441	139283626	94	11201										
CFB	629	broad.mit.edu	37	chr6	31919363	31919363	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggccccttgatagttcacaaGagaagtcgtttcattcaagt	9	9	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:31919363G>A	uc003nyj.3	+	17	2399	c.2121G>A	c.(2119-2121)AAG>AAA	p.K707K	CFB_uc011dor.1_Silent_p.K1209K	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	707	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						TAGTTCACAAGAGAAGTCGTT	0.512													0	0	0	0.00361	0	65	164										A	31919363	G	A	31919363	2	1	43	1	0	0	0	0	0	0	0	1	3278	933	33	1		1	CFB	6	31919363	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	87922	31919363	139195704	95	11202										
PSMB8	5696	broad.mit.edu	37	chr6	32808759	32808759	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttgattggcttcccggtactGgtgcagcaggtcactgacat	12	10	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:32808759G>A	uc003oce.2	-	6	851	c.808C>T	c.(808-810)CAG>TAG	p.Q270*	TAP2_uc011dqf.1_5'Flank|TAP2_uc003ocb.1_5'Flank|TAP2_uc003occ.2_5'Flank|TAP2_uc003ocd.2_5'Flank|PSMB8_uc003ocf.2_Nonsense_Mutation_p.Q266*	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	270					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						TCCCGGTACTGGTGCAGCAGG	0.512													0	0	0	0.00361	0	49	48										A	32808759	G	A	32808759	4	1	43	1	0	0	0	0	0	1	0	0	12683	1357	47	2	26	2	PSMB8	6	32808759	Nonsense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	889396	32808759	138306308	96	11203										
BRD2	6046	broad.mit.edu	37	chr6	32945996	32945996	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aaaaagagaaaaagaagaaaCggaaggcagagaagcatcga	12	4	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:32945996C>A	uc003ocn.3	+	10	3373	c.1672C>A	c.(1672-1674)CGG>AGG	p.R558R	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.R558R|BRD2_uc003ocp.3_Silent_p.R438R|BRD2_uc010juh.2_Silent_p.R558R	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	558	Poly-Lys.|Nuclear localization signal (Potential).|Arg/Lys-rich (highly basic).		R -> G (in a gastric adenocarcinoma sample; somatic mutation).		spermatogenesis	nucleus	protein serine/threonine kinase activity	p.R558G(1)		central_nervous_system(3)|stomach(2)	5						AAAGAAGAAACGGAAGGCAGA	0.527													1	0	1.08611e-07	0.010729	1.15606e-07	12	63										A	32945996	C	A	32945996	2	1	43	1	0	0	0	0	0	0	0	1	1502	527	19	4		4	BRD2	6	32945996	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	137237	32945996	138169071	97	11204										
B3GALT4	8705	broad.mit.edu	37	chr6	33245680	33245680	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcagcgggctgaactgggctGagaaacactgccccatggcc	13	13	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:33245680G>T	uc003odr.2	+	1	764	c.484G>T	c.(484-486)GAG>TAG	p.E162*		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	162	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						GAACTGGGCTGAGAAACACTG	0.607													1	0	4.26978e-12	0.00333	4.72081e-12	25	77										T	33245680	G	T	33245680	4	4	43	1	0	0	0	0	0	1	0	0	1249	1291	45	3	486	3	B3GALT4	6	33245680	Nonsense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	299684	33245680	137869387	98	11205										
MDFI	4188	broad.mit.edu	37	chr6	41621154	41621154	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acctgtggctcctgcagctcGgaggactcgtgcctctgctg	13	14	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:41621154G>C	uc003oqp.3	+	6	911	c.582G>C	c.(580-582)TCG>TCC	p.S194S	MDFI_uc003oqq.3_Silent_p.S194S|MDFI_uc010jxn.2_Silent_p.S194S	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	194	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			CCTGCAGCTCGGAGGACTCGT	0.647													0	0	0	0.00499	0	9	14										C	41621154	G	C	41621154	2	2	43	1	0	0	0	0	0	0	0	1	9404	1103	39	4		4	MDFI	6	41621154	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	8375474	41621154	129493913	99	11206										
C6orf223	221416	broad.mit.edu	37	chr6	43970834	43970834	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgctgtcatccgcggcgctcCgcggcgctgggccaacgcgc	15	18	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:43970834C>T	uc003own.2	+	4	718	c.700C>T	c.(700-702)CGC>TGC	p.R234C	uc003owm.1_Intron|C6orf223_uc003owo.2_Missense_Mutation_p.R214C	NM_153246	NP_694978	Q8N319	CF223_HUMAN	hypothetical protein LOC221416	234											0	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			CGCGGCGCTCCGCGGCGCTGG	0.667													0	0	0	0.004482	0	5	9										T	43970834	C	T	43970834	3	4	43	1	0	0	0	0	1	0	0	0	2357	652	23	2	757	2	C6orf223	6	43970834	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	2349680	43970834	127144233	100	11207										
DST	667	broad.mit.edu	37	chr6	56325021	56325021	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccctgataaatatcctggaAgtcgaagcttgcttccttgt	8	10	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:56325021A>T	uc003pdf.2	-	96	16701	c.16673T>A	c.(16672-16674)CTT>CAT	p.L5558H	DST_uc003pcz.3_Missense_Mutation_p.L5380H|DST_uc011dxj.1_Missense_Mutation_p.L5409H|DST_uc011dxk.1_Missense_Mutation_p.L5420H|DST_uc003pcy.3_Missense_Mutation_p.L5054H|DST_uc003pcv.3_Missense_Mutation_p.L176H|DST_uc003pcw.3_Missense_Mutation_p.L137H|DST_uc003pcx.3_Missense_Mutation_p.L100H	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7453					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATATCCTGGAAGTCGAAGCTT	0.463													0	0	0	0.010504	0	19	25										T	56325021	A	T	56325021	3	4	43	1	0	0	0	0	1	0	0	0	4783	72	3	5	362	5	DST	6	56325021	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	12354187	56325021	114790046	101	11208										
PHIP	55023	broad.mit.edu	37	chr6	79655145	79655145	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aattattcctagtgccatgaCtaaaactggattgaccagga	8	8	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:79655145C>G	uc003pir.2	-	39	4926	c.4700G>C	c.(4699-4701)AGT>ACT	p.S1567T	PHIP_uc003piq.2_Missense_Mutation_p.S591T|PHIP_uc011dyp.1_Missense_Mutation_p.S1566T|IRAK1BP1_uc010kbg.1_RNA|PHIP_uc003pio.3_Missense_Mutation_p.S453T	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1567					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		AGTGCCATGACTAAAACTGGA	0.348													0	0	0	0.004007	0	16	39										G	79655145	C	G	79655145	3	3	43	1	0	0	0	0	1	0	0	0	11842	565	20	4	773	4	PHIP	6	79655145	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	23330124	79655145	91459922	102	11209										
IBTK	25998	broad.mit.edu	37	chr6	82910359	82910359	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaagatatctccatcttctaCttccaaatagctaatatctg	4	10	4	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:82910359C>T	uc003pjl.1	-	20	3384	c.2857G>A	c.(2857-2859)GTA>ATA	p.V953I	IBTK_uc011dyu.1_5'UTR|IBTK_uc011dyv.1_Missense_Mutation_p.V953I|IBTK_uc011dyw.1_Missense_Mutation_p.V752I|IBTK_uc010kbi.1_Missense_Mutation_p.V647I|IBTK_uc003pjm.2_Missense_Mutation_p.V953I	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	953					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CCATCTTCTACTTCCAAATAG	0.269													0	0	0	0.003163	0	16	12										T	82910359	C	T	82910359	3	4	43	1	0	0	0	0	1	0	0	0	7476	565	20	2	1244	2	IBTK	6	82910359	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	3255214	82910359	88204708	103	11210										
ZNF292	23036	broad.mit.edu	37	chr6	87970340	87970340	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aaggaaggaataaaaatgccCaagaccaaacgaaagaaaaa	8	6	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:87970340C>G	uc003plm.3	+	8	7034	c.6993C>G	c.(6991-6993)CCC>CCG	p.P2331P		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAAAAATGCCCAAGACCAAAC	0.378													0	0	0	0.003163	0	14	12										G	87970340	C	G	87970340	2	3	43	1	0	0	0	0	0	0	0	1	17823	581	21	4		4	ZNF292	6	87970340	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	5059981	87970340	83144727	104	11211										
PRDM1	639	broad.mit.edu	37	chr6	106547284	106547284	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccccgggagcaaaacctggCtgcgtgtcagaacgggatga	14	11	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:106547284C>A	uc003prd.2	+	4	755	c.521C>A	c.(520-522)GCT>GAT	p.A174D	PRDM1_uc003pre.2_Missense_Mutation_p.A40D	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	174	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.Y174*(1)		haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		CAAAACCTGGCTGCGTGTCAG	0.502			D|N|Mis|F|S		DLBCL								1	0	1.22574e-08	0.002299	1.32718e-08	23	37										A	106547284	C	A	106547284	3	1	43	1	0	0	0	0	1	0	0	0	12450	797	28	4	548	4	PRDM1	6	106547284	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	18576944	106547284	64567783	105	11212										
SGK1	6446	broad.mit.edu	37	chr6	134493873	134493887	+	In_Frame_Del	DEL	GTTCCAGGAAGCAGC	GTTCCAGGAAGCAGC	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agcatagaaacgagcccgtgGttccaggaagcagcgttccc							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:134493873_134493887delGTTCCAGGAAGCAGC	uc003qen.3	-	7	664_678	c.575_589delGCTGCTTCCTGGAAC	c.(574-591)CGCTGCTTCCTGGAACCA>CCA	p.RCFLE192del	SGK1_uc003qeo.3_In_Frame_Del_p.RCFLE287del|SGK1_uc011ect.1_In_Frame_Del_p.RCFLE182del|SGK1_uc011ecu.1_In_Frame_Del_p.RCFLE148del|SGK1_uc011ecv.1_In_Frame_Del_p.RCFLE206del|SGK1_uc011ecw.1_In_Frame_Del_p.RCFLE220del	NM_005627	NP_005618	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1 isoform	192_196	Protein kinase.			E -> G (in Ref. 4; CAR58095).	apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(3)|stomach(1)|lung(1)|central_nervous_system(1)	6	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		CGAGCCCGTGGTTCCAGGAAGCAGCGTTCCCTCTG	0.46																		13	28	---	---								-	134493887	GTTCCAGGAAGCAGC	-	134493873	7	5	43	1	0	1	0	1	0	0	0	0	14207	1261	44	0	730	0	SGK1	6	134493873	In_Frame_Del	DEL	GTTCCAGGAAGCAGC	TCGA-DK-A1A7-01A-11D-A13W-08	27946589	134493873	36621194	106	11213										
IL20RA	53832	broad.mit.edu	37	chr6	137325794	137325794	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttctctttgccaacgtggatAtatcggtagatggaatagcc	10	8	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:137325794A>G	uc003qhj.2	-	6	1261	c.828T>C	c.(826-828)TAT>TAC	p.Y276Y	IL20RA_uc011edl.1_Silent_p.Y227Y|IL20RA_uc003qhk.2_Silent_p.Y165Y|IL20RA_uc003qhi.2_Silent_p.Y8Y	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	276	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		CAACGTGGATATATCGGTAGA	0.413													0	0	0	0.00361	0	134	77										G	137325794	A	G	137325794	2	3	43	1	0	0	0	0	0	0	0	1	7668	456	16	5		5	IL20RA	6	137325794	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2831921	137325794	33789273	107	11214										
HIVEP2	3097	broad.mit.edu	37	chr6	143092722	143092722	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atgggacagattcccataatCaaatgatttgctccgaactt	7	9	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:143092722C>G	uc003qjd.2	-	5	3897	c.3154G>C	c.(3154-3156)GAT>CAT	p.D1052H		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1052					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TTCCCATAATCAAATGATTTG	0.557													0	0	0	0.012213	0	33	22										G	143092722	C	G	143092722	3	3	43	1	0	0	0	0	1	0	0	0	7187	826	29	1	4210	1	HIVEP2	6	143092722	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	5766928	143092722	28022345	108	11215										
SYTL3	94120	broad.mit.edu	37	chr6	159181706	159181706	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agacagcgttcctcagagtaAtggagagctcacagtccggg	13	10	2	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:159181706A>C	uc003qrp.2	+	14	1587	c.1343A>C	c.(1342-1344)AAT>ACT	p.N448T	SYTL3_uc011efp.1_Missense_Mutation_p.N448T|SYTL3_uc003qro.2_Missense_Mutation_p.N380T|SYTL3_uc003qrq.2_Missense_Mutation_p.N380T|SYTL3_uc003qrr.2_Missense_Mutation_p.N448T|SYTL3_uc003qrs.2_Missense_Mutation_p.N380T|SYTL3_uc011efq.1_Missense_Mutation_p.N174T	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	448					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CCTCAGAGTAATGGAGAGCTC	0.557													0	0	0	0.010504	0	19	65										C	159181706	A	C	159181706	3	2	43	1	0	0	0	0	1	0	0	0	15481	101	4	5	1177	5	SYTL3	6	159181706	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	16088984	159181706	11933361	109	11216										
IGF2R	3482	broad.mit.edu	37	chr6	160483635	160483635	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agaactgtggaagcctgtccCgttgtcagagtggaaggtag	15	7	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr6:160483635C>G	uc003qta.2	+	26	3802	c.3654C>G	c.(3652-3654)CCC>CCG	p.P1218P		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1218	8.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AAGCCTGTCCCGTTGTCAGAG	0.463													0	0	0	0.006122	0	16	27										G	160483635	C	G	160483635	2	3	43	1	0	0	0	0	0	0	0	1	7576	639	23	4		4	IGF2R	6	160483635	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	1301929	160483635	10631432	110	11217										
INTS1	26173	broad.mit.edu	37	chr7	1527588	1527588	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggtgcacggtgggtaggagTagttgctagggccagacggg	21	6	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:1527588T>C	uc003skn.2	-	19	2425	c.2324A>G	c.(2323-2325)TAC>TGC	p.Y775C	INTS1_uc003skp.1_Missense_Mutation_p.Y122C	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	775					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		TGGGTAGGAGTAGTTGCTAGG	0.652													0	0	0	0.00361	0	61	85										C	1527588	T	C	1527588	3	2	43	1	0	0	0	0	1	0	0	0	7775	1638	57	5	4368	5	INTS1	7	1527588	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08		1527588	157611075	111	11218										
SDK1	221935	broad.mit.edu	37	chr7	4171955	4171955	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccctgtggtttttcccttcAgccccaggcccaccagtgag	9	16	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:4171955A>T	uc003smx.2	+	28	4269	c.4130_splice	c.e28-2	p.A1377_splice	SDK1_uc010kso.2_Splice_Site_p.A653_splice|SDK1_uc003smy.2_Splice_Site	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor						cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TTTTCCCTTCAGCCCCAGGCC	0.582													0	0	0	0.004482	0	8	12										T	4171955	A	T	4171955	5	4	43	1	0	0	0	0	0	0	1	0	13968	202	7	5	4238	5	SDK1	7	4171955	Splice_Site	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2644367	4171955	154966708	112	11219										
CYTH3	9265	broad.mit.edu	37	chr7	6210831	6210831	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggctgtgggctctgcactgAcctgtggactggaagacccc	14	12	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:6210831A>C	uc003spt.2	-	7	666	c.562_splice	c.e7+1	p.D188_splice	CYTH3_uc011jws.1_Splice_Site_p.D103_splice	NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						CTCTGCACTGACCTGTGGACT	0.662													0	0	0	0.007291	0	25	72										C	6210831	A	C	6210831	5	2	43	1	0	0	0	0	0	0	1	0	4205	289	10	5	663	5	CYTH3	7	6210831	Splice_Site	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2038876	6210831	152927832	113	11220										
ICA1	3382	broad.mit.edu	37	chr7	8260975	8260975	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcctgctctggttttatcttGgaaaccttgggatcgaagaa	10	8	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:8260975G>T	uc003srm.2	-	5	377	c.310C>A	c.(310-312)CAA>AAA	p.Q104K	ICA1_uc010ktr.2_Missense_Mutation_p.Q104K|ICA1_uc003srl.2_Missense_Mutation_p.Q92K|ICA1_uc003srn.3_Missense_Mutation_p.Q30K|ICA1_uc003srp.3_Missense_Mutation_p.Q103K|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.Q104K|ICA1_uc003srr.2_Missense_Mutation_p.Q103K|ICA1_uc003sro.3_Missense_Mutation_p.Q104K|ICA1_uc011jxg.1_Missense_Mutation_p.Q104K|ICA1_uc003srs.1_Missense_Mutation_p.Q104K	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	104	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		GTTTTATCTTGGAAACCTTGG	0.443													1	0	7.48243e-07	0.006214	7.88417e-07	10	101										T	8260975	G	T	8260975	3	4	43	1	0	0	0	0	1	0	0	0	7477	1357	47	4	1181	4	ICA1	7	8260975	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2050144	8260975	150877688	114	11221										
CDK13	8621	broad.mit.edu	37	chr7	40027759	40027772	+	Frame_Shift_Del	DEL	AGGAGCCAAGGAGA	AGGAGCCAAGGAGA	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aaaccacttacaccaagcatAggagccaaggagaaggagca							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:40027759_40027772delAGGAGCCAAGGAGA	uc003thh.3	+	2	2055_2068	c.1773_1786delAGGAGCCAAGGAGA	c.(1771-1788)ATAGGAGCCAAGGAGAAGfs	p.I591fs	CDK13_uc003thi.3_Frame_Shift_Del_p.I591fs|CDK13_uc011kbf.1_5'UTR	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	591_596					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						CACCAAGCATAGGAGCCAAGGAGAAGGAGCAACA	0.43																		12	40	---	---								-	40027772	AGGAGCCAAGGAGA	-	40027759	7	5	43	1	0	1	0	1	0	0	0	0	3129	410	15	0	1779	0	CDK13	7	40027759	Frame_Shift_Del	DEL	AGGAGCCAAGGAGA	TCGA-DK-A1A7-01A-11D-A13W-08	31766784	40027759	119110904	115	11222										
NPC1L1	29881	broad.mit.edu	37	chr7	44556935	44556935	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtgagtttttcaggggcttgTgataggccatgaacctggag	15	6	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:44556935T>C	uc003tlb.2	-	16	3295	c.3239A>G	c.(3238-3240)CAC>CGC	p.H1080R	NPC1L1_uc003tlc.2_Missense_Mutation_p.H1053R|NPC1L1_uc011kbw.1_Missense_Mutation_p.H1007R|NPC1L1_uc003tla.2_Missense_Mutation_p.H56R	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1080	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	CAGGGGCTTGTGATAGGCCAT	0.557													0	0	0	0.012319	0	20	49										C	44556935	T	C	44556935	3	2	43	1	0	0	0	0	1	0	0	0	10571	1696	59	5	860	5	NPC1L1	7	44556935	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	4529176	44556935	114581728	116	11223										
PPP1R9A	55607	broad.mit.edu	37	chr7	94540651	94540651	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgtgtatagggtgagatccaGgtataattcagactggggag	15	4	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:94540651G>A	uc003unp.2	+	2	1508	c.1226G>A	c.(1225-1227)AGG>AAG	p.R409K	PPP1R9A_uc010lfj.2_Missense_Mutation_p.R409K|PPP1R9A_uc011kif.1_Missense_Mutation_p.R409K|PPP1R9A_uc003unq.2_Missense_Mutation_p.R409K|PPP1R9A_uc011kig.1_Missense_Mutation_p.R409K	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	409						cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GTGAGATCCAGGTATAATTCA	0.423										HNSCC(28;0.073)			0	0	0	0.00278	0	24	21										A	94540651	G	A	94540651	3	1	43	1	0	0	0	0	1	0	0	0	12378	1000	35	2	1228	2	PPP1R9A	7	94540651	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	49983716	94540651	64598012	117	11224										
ACN9	57001	broad.mit.edu	37	chr7	96810409	96810409	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttttggcaccttcctcccagAagaaaaacttaatgactttc	5	11	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:96810409A>G	uc003uoo.3	+	2	1391	c.260A>G	c.(259-261)GAA>GGA	p.E87G		NM_020186	NP_064571	Q9NRP4	ACN9_HUMAN	ACN9 homolog precursor	87					regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					TTCCTCCCAGAAGAAAAACTT	0.388													0	0	0	0.005524	0	38	24										G	96810409	A	G	96810409	3	3	43	1	0	0	0	0	1	0	0	0	145	246	9	5	266	5	ACN9	7	96810409	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2269758	96810409	62328254	118	11225										
TECPR1	25851	broad.mit.edu	37	chr7	97863074	97863074	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cagcccccaggcctgaggctGagttccctgtggcattcttg	12	14	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:97863074G>A	uc003upg.2	-	11	1536	c.1331C>T	c.(1330-1332)TCA>TTA	p.S444L	TECPR1_uc003uph.1_Missense_Mutation_p.S374L	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	444						integral to membrane	protein binding			pancreas(1)	1						GCCTGAGGCTGAGTTCCCTGT	0.647													0	0	0	0.00308	0	6	7										A	97863074	G	A	97863074	3	1	43	1	0	0	0	0	1	0	0	0	15740	1294	45	1	2230	1	TECPR1	7	97863074	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1052665	97863074	61275589	119	11226										
LRCH4	4034	broad.mit.edu	37	chr7	100172746	100172746	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggcctaggaacccaggagcCgagtgtaggtgacatagagc	16	9	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:100172746C>G	uc003uvj.2	-	18	2089	c.2036G>C	c.(2035-2037)CGG>CCG	p.R679P	uc003uvh.2_5'Flank|LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjw.1_3'UTR	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	679					nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACCCAGGAGCCGAGTGTAGGT	0.637													0	0	0	0.004672	0	3	14										G	100172746	C	G	100172746	3	3	43	1	0	0	0	0	1	0	0	0	8935	652	23	4	19	4	LRCH4	7	100172746	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	2309672	100172746	58965917	120	11227										
LRRC17	10234	broad.mit.edu	37	chr7	102574512	102574512	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggtcaaacgctacgcaccagGcctcccgtgtgacgtgtaca	11	14	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:102574512G>A	uc003vau.2	+	2	541	c.152G>A	c.(151-153)GGC>GAC	p.G51D	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.G51D	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	51					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						TACGCACCAGGCCTCCCGTGT	0.542													0	0	0	0.001168	0	6	31										A	102574512	G	A	102574512	3	1	43	1	0	0	0	0	1	0	0	0	8973	1203	42	2	154	2	LRRC17	7	102574512	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2401766	102574512	56564151	121	11228										
PTPRZ1	5803	broad.mit.edu	37	chr7	121650516	121650516	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cactacaatcgcatagggacGaaatacaatgaagccaagac	8	10	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:121650516G>A	uc003vjy.2	+	12	1811	c.1416G>A	c.(1414-1416)ACG>ACA	p.T472T	PTPRZ1_uc003vjz.2_Silent_p.T472T|PTPRZ1_uc011knt.1_5'UTR	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	472	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GCATAGGGACGAAATACAATG	0.433													0	0	0	0.00361	0	42	32										A	121650516	G	A	121650516	2	1	43	1	0	0	0	0	0	0	0	1	12814	1045	37	1		1	PTPRZ1	7	121650516	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	19076004	121650516	37488147	122	11229										
SPAM1	6677	broad.mit.edu	37	chr7	123599683	123599683	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aaactggaattcaagtgactAtcttcacctcaacccagata	5	11	4	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:123599683A>G	uc003vld.2	+	6	1592	c.1190A>G	c.(1189-1191)TAT>TGT	p.Y397C	SPAM1_uc003vle.2_Missense_Mutation_p.Y397C|SPAM1_uc011koa.1_Missense_Mutation_p.Y53C|SPAM1_uc003vlf.3_Missense_Mutation_p.Y397C|SPAM1_uc010lku.2_Missense_Mutation_p.Y397C	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	397					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	TCAAGTGACTATCTTCACCTC	0.418													0	0	0	0.008871	0	18	38										G	123599683	A	G	123599683	3	3	43	1	0	0	0	0	1	0	0	0	14986	449	16	5	1200	5	SPAM1	7	123599683	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	1949167	123599683	35538980	123	11230										
LRGUK	136332	broad.mit.edu	37	chr7	133884160	133884160	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttccgggatattttgatgaGgtaatcaatgcaggttggta	12	4	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:133884160G>A	uc003vrm.1	+	14	1750	c.1734G>A	c.(1732-1734)GAG>GAA	p.E578E		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	578	Guanylate kinase-like.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						ATTTTGATGAGGTAATCAATG	0.318													0	0	0	0.004656	0	24	87										A	133884160	G	A	133884160	2	1	43	1	0	0	0	0	0	0	0	1	8943	991	35	2		2	LRGUK	7	133884160	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	10284477	133884160	25254503	124	11231										
HIPK2	28996	broad.mit.edu	37	chr7	139299121	139299121	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttcctgtctgcaggggcatgCtccgctgggccactgcagcc	13	15	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:139299121C>T	uc003vvf.3	-	8	2075	c.1901G>A	c.(1900-1902)AGC>AAC	p.S634N	HIPK2_uc003vvd.3_Missense_Mutation_p.S607N	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	634	Interaction with SKI and SMAD1.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					CAGGGGCATGCTCCGCTGGGC	0.577													0	0	0	0.004672	0	3	11										T	139299121	C	T	139299121	3	4	43	1	0	0	0	0	1	0	0	0	7117	797	28	2	1727	2	HIPK2	7	139299121	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	5414961	139299121	19839542	125	11232										
TPK1	27010	broad.mit.edu	37	chr7	144320258	144320258	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccaaatacatgtatatattaCctttaagtctttttcttcta	2	8	3	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr7:144320258C>T	uc003weq.2	-	6	457	c.354_splice	c.e6+1	p.K118_splice	TPK1_uc003weo.2_Splice_Site_p.K113_splice|TPK1_uc003wep.2_Splice_Site|TPK1_uc003wer.2_Splice_Site_p.K118_splice|TPK1_uc003wes.2_Splice_Site	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a						thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	GTATATATTACCTTTAAGTCT	0.328													0	0	0	0.00361	0	62	64										T	144320258	C	T	144320258	5	4	43	1	0	0	0	0	0	0	1	0	16401	521	18	2	392	2	TPK1	7	144320258	Splice_Site	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	5021137	144320258	14818405	126	11233										
LPL	4023	broad.mit.edu	37	chr8	19818562	19818562	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cccggcttcgccattcagaaGatcagagtaaaagcaggaga	11	10	2	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:19818562G>A	uc003wzk.3	+	8	1660	c.1290G>A	c.(1288-1290)AAG>AAA	p.K430K		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	430	PLAT.|Heparin-binding (By similarity).				fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	CCATTCAGAAGATCAGAGTAA	0.428													0	0	0	0.00278	0	21	16										A	19818562	G	A	19818562	2	1	43	1	0	0	0	0	0	0	0	1	8921	933	33	1		1	LPL	8	19818562	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08		19818562	126545460	127	11234										
EIF4EBP1	1978	broad.mit.edu	37	chr8	37914710	37914710	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggggtcaccagcccttccaGtgatgagccccccatggaag	13	14	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:37914710G>A	uc003xks.2	+	2	329	c.257G>A	c.(256-258)AGT>AAT	p.S86N		NM_004095	NP_004086	Q13541	4EBP1_HUMAN	eukaryotic translation initiation factor 4E	86					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|positive regulation of mitotic cell cycle|TOR signaling cascade|translation	cytosol					0	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)				AGCCCTTCCAGTGATGAGCCC	0.602													0	0	0	0.003163	0	14	34										A	37914710	G	A	37914710	3	1	43	1	0	0	0	0	1	0	0	0	5032	1029	36	2	263	2	EIF4EBP1	8	37914710	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	18096148	37914710	108449312	128	11235										
RP1	6101	broad.mit.edu	37	chr8	55541521	55541521	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tctagtagttcatctatgttGcaggaattccaggaggaaag	11	6	3	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:55541521G>T	uc003xsd.1	+	4	5227	c.5079G>T	c.(5077-5079)TTG>TTT	p.L1693F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1693					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CATCTATGTTGCAGGAATTCC	0.403													1	0	4.11147e-13	0.003755	4.57802e-13	38	236										T	55541521	G	T	55541521	3	4	43	1	0	0	0	0	1	0	0	0	13532	1310	46	4	5089	4	RP1	8	55541521	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	17626811	55541521	90822501	129	11236										
CLVS1	157807	broad.mit.edu	37	chr8	62366715	62366715	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cccaggacagctttcctgccCgctttggaggagtccacttt	10	14	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:62366715C>G	uc003xuh.2	+	4	970	c.646C>G	c.(646-648)CGC>GGC	p.R216G	CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Missense_Mutation_p.R216G	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	216	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CTTTCCTGCCCGCTTTGGAGG	0.493													0	0	0	0.00361	0	179	117										G	62366715	C	G	62366715	3	3	43	1	0	0	0	0	1	0	0	0	3571	652	23	4	656	4	CLVS1	8	62366715	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	6825194	62366715	83997307	130	11237										
CRH	1392	broad.mit.edu	37	chr8	67089287	67089287	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccggtgcctcctggtggccGccgagggcattcctagcgcc	14	16	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:67089287G>A	uc003xvy.1	-	2	611	c.426C>T	c.(424-426)GGC>GGT	p.G142G		NM_000756	NP_000747	P06850	CRF_HUMAN	corticotropin releasing hormone precursor	142					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CCTGGTGGCCGCCGAGGGCAT	0.667											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	10										A	67089287	G	A	67089287	2	1	43	1	0	0	0	0	0	0	0	1	3869	1074	38	2		2	CRH	8	67089287	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	4722572	67089287	79274735	131	11238										
SULF1	23213	broad.mit.edu	37	chr8	70539485	70539485	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	actctatccattgtgagagaGaactgtaccaatcggccaga	9	10	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:70539485G>A	uc010lza.1	+	16	2608	c.1891G>A	c.(1891-1893)GAA>AAA	p.E631K	SULF1_uc003xyd.2_Missense_Mutation_p.E631K|SULF1_uc003xye.2_Missense_Mutation_p.E631K|SULF1_uc003xyf.2_Missense_Mutation_p.E631K|SULF1_uc003xyg.2_Missense_Mutation_p.E631K|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_5'Flank	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	631					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTGTGAGAGAGAACTGTACCA	0.388													0	0	0	0.00361	0	69	48										A	70539485	G	A	70539485	3	1	43	1	0	0	0	0	1	0	0	0	15369	943	33	1	1937	1	SULF1	8	70539485	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	3450198	70539485	75824537	132	11239										
ZFHX4	79776	broad.mit.edu	37	chr8	77763236	77763236	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acccttggaagtctcagaatGgaataaaaatagcagtaagg	10	6	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:77763236G>T	uc003yav.2	+	10	4331	c.3944G>T	c.(3943-3945)TGG>TTG	p.W1315L	ZFHX4_uc003yau.1_Missense_Mutation_p.W1360L|ZFHX4_uc003yaw.1_Missense_Mutation_p.W1315L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1315						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTCTCAGAATGGAATAAAAAT	0.423										HNSCC(33;0.089)			1	0	1.06961e-07	0.00308	1.14238e-07	8	33										T	77763236	G	T	77763236	3	4	43	1	0	0	0	0	1	0	0	0	17632	1357	47	4	4113	4	ZFHX4	8	77763236	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	7223751	77763236	68600786	133	11240										
NBN	4683	broad.mit.edu	37	chr8	90955588	90955607	+	Splice_Site	DEL	ATGTGACCTATTGAATAATA	ATGTGACCTATTGAATAATA	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aagttttcctgctccaggatAtgtgacctattgaataataa							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:90955588_90955607delATGTGACCTATTGAATAATA	uc003yej.1	-	14	2181	c.2071_splice	c.e14-1	p.V691_splice	NBN_uc003yei.1_Splice_Site_p.V609_splice|NBN_uc011lgb.1_Splice_Site_p.V691_splice	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin						cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			GCTCCAGGATATGTGACCTATTGAATAATAAAAGTAGTAC	0.336								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome									45	94	---	---								-	90955607	ATGTGACCTATTGAATAATA	-	90955588	8	5	43	1	0	1	0	1	0	0	1	0	10191	449	16	0	199	0	NBN	8	90955588	Splice_Site	DEL	ATGTGACCTATTGAATAATA	TCGA-DK-A1A7-01A-11D-A13W-08	13192352	90955588	55408434	134	11241										
VPS13B	157680	broad.mit.edu	37	chr8	100146891	100146891	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gcaagttgagagtagttattAcagtccacagaaagtaaaat	9	5	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:100146891A>G	uc003yiv.2	+	9	1349	c.1238A>G	c.(1237-1239)TAC>TGC	p.Y413C	VPS13B_uc003yiw.2_Missense_Mutation_p.Y413C|VPS13B_uc003yit.2_Missense_Mutation_p.Y413C|VPS13B_uc003yiu.1_Missense_Mutation_p.Y413C|VPS13B_uc003yix.1_5'Flank	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	413					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGTAGTTATTACAGTCCACAG	0.274													0	0	0	0.002836	0	32	124										G	100146891	A	G	100146891	3	3	43	1	0	0	0	0	1	0	0	0	17187	391	14	5	1310	5	VPS13B	8	100146891	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	9191303	100146891	46217131	135	11242										
MAF1	84232	broad.mit.edu	37	chr8	145161270	145161270	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgaatgcagtcaactgcagtCtgttctcagctgtgcgggag	13	9	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr8:145161270C>A	uc003zbc.1	+	5	904	c.403C>A	c.(403-405)CTG>ATG	p.L135M	SHARPIN_uc003zba.2_5'Flank|SHARPIN_uc003zbb.2_5'Flank|KIAA1875_uc003zbd.3_5'Flank|KIAA1875_uc011lky.1_5'Flank	NM_032272	NP_115648	Q9H063	MAF1_HUMAN	MAF1 protein	135					negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	cytoplasm|nucleus					0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.1e-42)|Epithelial(56;1.23e-40)|all cancers(56;4.84e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAACTGCAGTCTGTTCTCAGC	0.582													1	0	6.38683e-12	0.008361	7.03672e-12	30	15										A	145161270	C	A	145161270	3	1	43	1	0	0	0	0	1	0	0	0	9156	912	32	3	417	3	MAF1	8	145161270	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	45014379	145161270	1202752	136	11243										
SMARCA2	6595	broad.mit.edu	37	chr9	2086985	2086985	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccctgaactctgggccctcCtcaacttcctcctcccaaca	4	20	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:2086985C>G	uc003zhc.2	+	18	2782	c.2683C>G	c.(2683-2685)CTC>GTC	p.L895V	SMARCA2_uc003zhd.2_Missense_Mutation_p.L895V|SMARCA2_uc010mha.2_Intron	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	895	Helicase ATP-binding.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CTGGGCCCTCCTCAACTTCCT	0.507													0	0	0	0.00361	0	75	13										G	2086985	C	G	2086985	3	3	43	1	0	0	0	0	1	0	0	0	14769	681	24	4	2749	4	SMARCA2	9	2086985	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		2086985	139126446	137	11244										
INSL4	3641	broad.mit.edu	37	chr9	5231710	5231710	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggtggctgctggaatctggaCgtcccaaaggtgagagccct	15	10	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:5231710C>T	uc003ziy.2	+	1	292	c.187C>T	c.(187-189)CGT>TGT	p.R63C		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	63					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GGAATCTGGACGTCCCAAAGG	0.517													0	0	0	0.002299	0	22	7										T	5231710	C	T	5231710	3	4	43	1	0	0	0	0	1	0	0	0	7768	536	19	2	189	2	INSL4	9	5231710	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	3144725	5231710	135981721	138	11245										
KIAA1045	23349	broad.mit.edu	37	chr9	34976675	34976675	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	accctgaacatcgaggccacAtagagtggcctgacttcttg	10	12	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:34976675A>G	uc003zvq.2	+	5	965	c.787A>G	c.(787-789)ATA>GTA	p.I263V	KIAA1045_uc003zvr.2_Missense_Mutation_p.I263V	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	263							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			TCGAGGCCACATAGAGTGGCC	0.622													0	0	0	0.00361	0	66	60										G	34976675	A	G	34976675	3	3	43	1	0	0	0	0	1	0	0	0	8207	217	8	5	801	5	KIAA1045	9	34976675	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	29744965	34976675	106236756	139	11246										
TMOD1	7111	broad.mit.edu	37	chr9	100326379	100326379	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aagaaccaaattcaacagacGtagaggaaacgctggaacgg	11	8	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:100326379G>C	uc004axk.1	+	6	760	c.547G>C	c.(547-549)GTA>CTA	p.V183L	TMOD1_uc004axl.1_Missense_Mutation_p.V183L	NM_003275	NP_003266	P28289	TMOD1_HUMAN	tropomodulin 1	183					muscle filament sliding	cytosol	actin binding				0		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		TTCAACAGACGTAGAGGAAAC	0.443													0	0	0	0.012319	0	17	22										C	100326379	G	C	100326379	3	2	43	1	0	0	0	0	1	0	0	0	16230	1145	40	4	565	4	TMOD1	9	100326379	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	65349704	100326379	40887052	140	11247										
TSTD2	158427	broad.mit.edu	37	chr9	100367863	100367863	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aagttctagatttttgtcaaCgtagctagggaagtaactga	10	5	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:100367863C>T	uc004axn.2	-	8	1503	c.1015G>A	c.(1015-1017)GTT>ATT	p.V339I	TSTD2_uc004axo.2_Missense_Mutation_p.V113I|TSTD2_uc004axp.1_Missense_Mutation_p.V113I	NM_139246	NP_640339	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like	339	Rhodanese.									ovary(2)	2						TTTTTGTCAACGTAGCTAGGG	0.463													0	0	0	0.003271	0	36	77										T	100367863	C	T	100367863	3	4	43	1	0	0	0	0	1	0	0	0	16672	536	19	2	547	2	TSTD2	9	100367863	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	41484	100367863	40845568	141	11248										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123232480	123232480	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gataagatgtttgatcactaTaaagtgaaaatgattcttct	7	4	3	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:123232480T>C	uc004bkf.2	-	17	2058	c.1877A>G	c.(1876-1878)TAT>TGT	p.Y626C	CDK5RAP2_uc004bke.2_5'UTR|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.Y626C|CDK5RAP2_uc011lxw.1_5'UTR|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_5'UTR|CDK5RAP2_uc011lya.1_5'UTR|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.Y625C|CDK5RAP2_uc004bki.2_Missense_Mutation_p.Y425C	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	626					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						TTGATCACTATAAAGTGAAAA	0.363													0	0	0	0.001984	0	7	19										C	123232480	T	C	123232480	3	2	43	1	0	0	0	0	1	0	0	0	3146	1406	49	5	3892	5	CDK5RAP2	9	123232480	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	22864617	123232480	17980951	142	11249										
SPTAN1	6709	broad.mit.edu	37	chr9	131329130	131329130	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaactctcaacccttaggcgTcagaagctggaagattccta	9	11	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr9:131329130T>C	uc004bvl.3	+	2	224	c.111T>C	c.(109-111)CGT>CGC	p.R37R	SPTAN1_uc011mbg.1_Silent_p.R37R|SPTAN1_uc011mbh.1_Silent_p.R49R|SPTAN1_uc004bvm.3_Silent_p.R37R|SPTAN1_uc004bvn.3_Silent_p.R37R	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	37	Spectrin 1.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCCTTAGGCGTCAGAAGCTGG	0.493													0	0	0	0.00361	0	72	55										C	131329130	T	C	131329130	2	2	43	1	0	0	0	0	0	0	0	1	15116	1654	58	5		5	SPTAN1	9	131329130	Silent	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	8096650	131329130	9884301	143	11250										
ACBD7	414149	broad.mit.edu	37	chr10	15058950	15058950	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggtgaacaaatattcatagcCataagccgctttgcagttca	8	9	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:15058950C>T	uc010qby.1	-	7	550	c.241G>A	c.(241-243)GGC>AGC	p.G81S				Q8N6N7	ACBD7_HUMAN	SubName: Full=cDNA FLJ52263, highly similar to Artemis protein (EC 3.1.-.-);	Error:Variant_position_missing_in_Q8N6N7_after_alignment							fatty-acyl-CoA binding				0						TATTCATAGCCATAAGCCGCT	0.373													0	0	0	0.007291	0	30	117										T	15058950	C	T	15058950	3	4	43	1	0	0	0	0	1	0	0	0	127	609	21	2		2	ACBD7	10	15058950	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		15058950	120475797	144	11251										
ABI1	10006	broad.mit.edu	37	chr10	27112231	27112231	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	taaagcttttctcttgtctgTagcctgaaataagaacaaaa	6	7	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:27112231T>C	uc001isx.2	-	2	288	c.121A>G	c.(121-123)ACA>GCA	p.T41A	ABI1_uc001ite.2_Missense_Mutation_p.T41A|ABI1_uc010qdh.1_Missense_Mutation_p.T41A|ABI1_uc010qdi.1_Missense_Mutation_p.T41A|ABI1_uc001isy.2_Missense_Mutation_p.T41A|ABI1_uc001ita.2_Missense_Mutation_p.T41A|ABI1_uc001isz.2_Missense_Mutation_p.T41A|ABI1_uc001itb.2_Missense_Mutation_p.T58A|ABI1_uc001itc.2_Missense_Mutation_p.T41A|ABI1_uc010qdj.1_Missense_Mutation_p.T41A|ABI1_uc001itd.2_Missense_Mutation_p.T41A|ABI1_uc010qdk.1_Missense_Mutation_p.T41A	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	41	Required for binding to WASF1 (By similarity).				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						CTCTTGTCTGTAGCCTGAAAT	0.303													0	0	0	0.006122	0	18	47										C	27112231	T	C	27112231	3	2	43	1	0	0	0	0	1	0	0	0	88	1638	57	5	1449	5	ABI1	10	27112231	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	12053281	27112231	108422516	145	11252										
SYNPO2L	79933	broad.mit.edu	37	chr10	75406722	75406722	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gccaggggttctgcagtgggCtggggtgccggagtggaaaa	20	7	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:75406722C>T	uc001jut.3	-	4	2840	c.2688G>A	c.(2686-2688)CAG>CAA	p.Q896Q	SYNPO2L_uc001jus.3_Silent_p.Q672Q	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	896	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					CTGCAGTGGGCTGGGGTGCCG	0.627													0	0	0	0.010818	0	31	13										T	75406722	C	T	75406722	2	4	43	1	0	0	0	0	0	0	0	1	15455	796	28	2		2	SYNPO2L	10	75406722	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	48294491	75406722	60128025	146	11253										
FAM178A	55719	broad.mit.edu	37	chr10	102684688	102684688	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cagctacaggaaagcctcctGctctttccaaggggcttaga	10	12	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:102684688G>A	uc001krt.3	+	5	2472	c.1930G>A	c.(1930-1932)GCT>ACT	p.A644T	FAM178A_uc001krr.1_Missense_Mutation_p.A644T|FAM178A_uc001krs.2_Missense_Mutation_p.A644T|FAM178A_uc001kru.1_Missense_Mutation_p.A579T	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	644											0						AAAGCCTCCTGCTCTTTCCAA	0.403													0	0	0	0.00361	0	89	37										A	102684688	G	A	102684688	3	1	43	1	0	0	0	0	1	0	0	0	5503	1319	46	2	1948	2	FAM178A	10	102684688	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	27277966	102684688	32850059	147	11254										
CNNM2	54805	broad.mit.edu	37	chr10	104679190	104679190	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggcaactacctgctgtgctCactgctgctgggcaacgtgc	13	13	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:104679190C>T	uc001kwm.2	+	1	1077	c.953C>T	c.(952-954)TCA>TTA	p.S318L	CNNM2_uc001kwn.2_Missense_Mutation_p.S318L|CNNM2_uc001kwl.2_Missense_Mutation_p.S318L	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	318	DUF21.|Helical; (Potential).				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CTGCTGTGCTCACTGCTGCTG	0.632													0	0	0	0.003163	0	15	9										T	104679190	C	T	104679190	3	4	43	1	0	0	0	0	1	0	0	0	3613	838	29	1	955	1	CNNM2	10	104679190	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	1994502	104679190	30855557	148	11255										
EIF3A	8661	broad.mit.edu	37	chr10	120817659	120817659	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctggagttcagcttccctctGttccaattcttctttctcac	5	14	5	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:120817659G>A	uc001ldu.2	-	12	1932	c.1786C>T	c.(1786-1788)CAG>TAG	p.Q596*	EIF3A_uc010qsu.1_Nonsense_Mutation_p.Q562*	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	596	Glu-rich.				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		GCTTCCCTCTGTTCCAATTCT	0.512													0	0	0	0.012213	0	33	99										A	120817659	G	A	120817659	4	1	43	1	0	0	0	0	0	1	0	0	5012	1386	48	2	2406	2	EIF3A	10	120817659	Nonsense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	16138469	120817659	14717088	149	11256										
C10orf90	118611	broad.mit.edu	37	chr10	128192613	128192613	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agttgtatggtccttttcccCttttcttacagtgacttggt	8	9	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:128192613C>T	uc001ljq.2	-	3	1277	c.1156G>A	c.(1156-1158)GGG>AGG	p.G386R	C10orf90_uc001ljp.2_Missense_Mutation_p.G339R|C10orf90_uc010qum.1_Missense_Mutation_p.G483R|C10orf90_uc009yao.2_Missense_Mutation_p.G483R|C10orf90_uc001ljs.1_Missense_Mutation_p.G339R	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	386										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TCCTTTTCCCCTTTTCTTACA	0.502											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00874	0	43	14										T	128192613	C	T	128192613	3	4	43	1	0	0	0	0	1	0	0	0	1623	681	24	2	971	2	C10orf90	10	128192613	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	7374954	128192613	7342134	150	11257										
MGMT	4255	broad.mit.edu	37	chr10	131565073	131565073	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tccccatcctcatcccgtgcCacagagtggtctgcagcagc	9	17	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:131565073C>G	uc001lkh.2	+	5	555	c.529C>G	c.(529-531)CAC>GAC	p.H177D		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	146										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		CATCCCGTGCCACAGAGTGGT	0.632								Direct_reversal_of_damage					0	0	0	0.000602	0	5	4										G	131565073	C	G	131565073	3	3	43	1	0	0	0	0	1	0	0	0	9557	594	21	4	547	4	MGMT	10	131565073	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	3372460	131565073	3969674	151	11258										
DPYSL4	10570	broad.mit.edu	37	chr10	134018389	134018389	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgacgcacagcacagaagatCatggcaccacctggcggccg	12	15	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:134018389C>T	uc009ybb.2	+	14	1828	c.1674C>T	c.(1672-1674)ATC>ATT	p.I558I		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	558					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		CACAGAAGATCATGGCACCAC	0.672													0	0	0	0.002836	0	31	139										T	134018389	C	T	134018389	2	4	43	1	0	0	0	0	0	0	0	1	4749	816	29	1		1	DPYSL4	10	134018389	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	2453316	134018389	1516358	152	11259										
KNDC1	85442	broad.mit.edu	37	chr10	135011911	135011911	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtgcccggccagcacccctgCggtgaagaagccacccagct	12	17	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr10:135011911C>T	uc001llz.1	+	13	1978	c.1977C>T	c.(1975-1977)TGC>TGT	p.C659C	KNDC1_uc001lma.1_Silent_p.C594C|KNDC1_uc001lmb.1_Silent_p.C71C	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	659					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGCACCCCTGCGGTGAAGAAG	0.682													0	0	0	0.009096	0	4	5										T	135011911	C	T	135011911	2	4	43	1	0	0	0	0	0	0	0	1	8426	776	27	2		2	KNDC1	10	135011911	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	993522	135011911	522836	153	11260										
OR56B4	196335	broad.mit.edu	37	chr11	6129404	6129404	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtagacagatacatagccatCtgtcgccctcttcagtaccc	7	14	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:6129404C>T	uc010qzx.1	+	1	396	c.396C>T	c.(394-396)ATC>ATT	p.I132I		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATAGCCATCTGTCGCCCTC	0.498													0	0	0	0.00361	0	69	25										T	6129404	C	T	6129404	2	4	43	1	0	0	0	0	0	0	0	1	11138	903	32	1		1	OR56B4	11	6129404	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		6129404	128877112	154	11261										
PIK3C2A	5286	broad.mit.edu	37	chr11	17115836	17115836	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cttccaaagtggaaaaataaTactgagcttattgtgaagtt	8	5	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:17115836T>C	uc001mmq.3	-	27	4489	c.4423A>G	c.(4423-4425)ATT>GTT	p.I1475V	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.I1095V|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1475	PX.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GGAAAAATAATACTGAGCTTA	0.348													0	0	0	0.002299	0	22	9										C	17115836	T	C	17115836	3	2	43	1	0	0	0	0	1	0	0	0	11909	1406	49	5	661	5	PIK3C2A	11	17115836	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	10986432	17115836	117890680	155	11262										
MRGPRX1	259249	broad.mit.edu	37	chr11	18955715	18955715	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tggtcagcggtatcttccggGatccacagagaatcctgatc	11	11	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:18955715G>A	uc001mpg.2	-	1	835	c.617C>T	c.(616-618)TCC>TTC	p.S206F		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	206	Cytoplasmic (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						TATCTTCCGGGATCCACAGAG	0.502													0	0	0	0.001368	0	11	52										A	18955715	G	A	18955715	3	1	43	1	0	0	0	0	1	0	0	0	9766	1174	41	1	355	1	MRGPRX1	11	18955715	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1839879	18955715	116050801	156	11263										
CAT	847	broad.mit.edu	37	chr11	34489896	34489896	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaaacgtctgtgtgagaacaTtgccggccacctgaaggatg	13	9	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:34489896T>C	uc001mvm.2	+	11	1471	c.1388T>C	c.(1387-1389)ATT>ACT	p.I463T	CAT_uc001mvn.2_Missense_Mutation_p.I72T	NM_001752	NP_001743	P04040	CATA_HUMAN	catalase	463					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	TGTGAGAACATTGCCGGCCAC	0.488													0	0	0	0.00361	0	82	20										C	34489896	T	C	34489896	3	2	43	1	0	0	0	0	1	0	0	0	2686	1493	52	5	1430	5	CAT	11	34489896	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	15534181	34489896	100516620	157	11264										
OR8H2	390151	broad.mit.edu	37	chr11	55872916	55872916	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctgcagtcctctacactacaCagttattatgtccaaaaggc	6	12	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:55872916C>A	uc010riy.1	+	1	398	c.398C>A	c.(397-399)ACA>AAA	p.T133K		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CTACACTACACAGTTATTATG	0.463										HNSCC(53;0.14)			1	0	1.02165e-56	0.00361	1.16231e-56	140	78										A	55872916	C	A	55872916	3	1	43	1	0	0	0	0	1	0	0	0	11238	478	17	4	400	4	OR8H2	11	55872916	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	21383020	55872916	79133600	158	11265										
C11orf9	745	broad.mit.edu	37	chr11	61544788	61544806	+	Frame_Shift_Del	DEL	CACAGGTGCCCGACACCGT	CACAGGTGCCCGACACCGT	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgatgtgttgtggcagcgggCacaggtgcccgacaccgtct					rs75764154	byFrequency	TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:61544788_61544806delCACAGGTGCCCGACACCGT	uc001nsc.1	+	12	1739_1757	c.1643_1661delCACAGGTGCCCGACACCGT	c.(1642-1662)GCACAGGTGCCCGACACCGTCfs	p.A548fs	C11orf9_uc001nse.1_Frame_Shift_Del_p.A539fs|C11orf9_uc010rll.1_5'Flank	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	548_554					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TGGCAGCGGGCACAGGTGCCCGACACCGTCTTCCACCAC	0.653																		8	13	---	---								-	61544806	CACAGGTGCCCGACACCGT	-	61544788	7	5	43	1	0	1	0	1	0	0	0	0	1671	710	25	0	1712	0	C11orf9	11	61544788	Frame_Shift_Del	DEL	CACAGGTGCCCGACACCGT	TCGA-DK-A1A7-01A-11D-A13W-08	5671872	61544788	73461728	159	11266										
ODZ4	26011	broad.mit.edu	37	chr11	78433795	78433795	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acccacatagaggctcccgtCagagccacaggtgagggcca	12	14	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:78433795C>T	uc001ozl.3	-	24	4181	c.3718G>A	c.(3718-3720)GAC>AAC	p.D1240N		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1240	Extracellular (Potential).|NHL 1.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						AGGCTCCCGTCAGAGCCACAG	0.562													0	0	0	0.00333	0	24	57										T	78433795	C	T	78433795	3	4	43	1	0	0	0	0	1	0	0	0	10837	826	29	1	4635	1	ODZ4	11	78433795	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	16889007	78433795	56572721	160	11267										
MMP20	9313	broad.mit.edu	37	chr11	102495964	102495964	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttcctccaggtcctgggggaGgctgcaactagggagggggc	18	10	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:102495964G>C	uc001phc.2	-	1	100	c.87C>G	c.(85-87)GCC>GCG	p.A29A		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	29					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		TCCTGGGGGAGGCTGCAACTA	0.537													0	0	0	0.00361	0	47	20										C	102495964	G	C	102495964	2	2	43	1	0	0	0	0	0	0	0	1	9659	987	35	4		4	MMP20	11	102495964	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	24062169	102495964	32510552	161	11268										
DCPS	28960	broad.mit.edu	37	chr11	126176504	126176504	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atggggatggagaggatgccGttgtgatcctggagaagacg	18	5	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr11:126176504G>A	uc001qdp.2	+	2	570	c.241G>A	c.(241-243)GTT>ATT	p.V81I		NM_014026	NP_054745	Q96C86	DCPS_HUMAN	mRNA decapping enzyme	81					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		AGAGGATGCCGTTGTGATCCT	0.572													0	0	0	0.001855	0	13	6										A	126176504	G	A	126176504	3	1	43	1	0	0	0	0	1	0	0	0	4301	1145	40	2	247	2	DCPS	11	126176504	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	23680540	126176504	8830012	162	11269										
NCAPD2	9918	broad.mit.edu	37	chr12	6623746	6623746	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgaagagcatagtgggagagAttgtaaggtgactcttcctt	13	5	1	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:6623746A>G	uc001qoo.2	+	8	878	c.832A>G	c.(832-834)ATT>GTT	p.I278V	NCAPD2_uc009zen.1_Missense_Mutation_p.I150V|NCAPD2_uc010sfd.1_Missense_Mutation_p.I233V	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	278	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						AGTGGGAGAGATTGTAAGGTG	0.443													0	0	0	0.002836	0	34	33										G	6623746	A	G	6623746	3	3	43	1	0	0	0	0	1	0	0	0	10205	333	12	5	858	5	NCAPD2	12	6623746	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08		6623746	127228149	163	11270										
RECQL	5965	broad.mit.edu	37	chr12	21627868	21627868	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aacttattctgaatatatctCcaaagccgtagtacaaaata	4	8	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:21627868C>T	uc001rex.2	-	12	1610	c.1262G>A	c.(1261-1263)GGA>GAA	p.G421E	RECQL_uc001rey.2_Missense_Mutation_p.G421E	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	421	Helicase C-terminal.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						GAATATATCTCCAAAGCCGTA	0.373								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.00361	0	107	54										T	21627868	C	T	21627868	3	4	43	1	0	0	0	0	1	0	0	0	13201	855	30	1	707	1	RECQL	12	21627868	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	15004122	21627868	112224027	164	11271										
ABCC9	10060	broad.mit.edu	37	chr12	22005388	22005388	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caggaatttcaaaatcccctCctgcattaaatgatcactca	4	12	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:22005388C>G	uc001rfi.1	-	21	2577	c.2557G>C	c.(2557-2559)GAG>CAG	p.E853Q	ABCC9_uc001rfh.2_Missense_Mutation_p.E853Q|ABCC9_uc001rfj.1_Missense_Mutation_p.E817Q	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	853	Cytoplasmic (Potential).|ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AAAATCCCCTCCTGCATTAAA	0.408													0	0	0	0.004007	0	16	205										G	22005388	C	G	22005388	3	3	43	1	0	0	0	0	1	0	0	0	59	864	30	1	2306	1	ABCC9	12	22005388	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	377520	22005388	111846507	165	11272										
DENND5B	160518	broad.mit.edu	37	chr12	31648850	31648850	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aaggactctggtcaaaatttTcgcctacaacaaataataca	5	9	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:31648850T>G	uc001rki.1	-	2	317	c.131A>C	c.(130-132)GAA>GCA	p.E44A	DENND5B_uc001rkh.1_Missense_Mutation_p.E79A|DENND5B_uc001rkj.2_Missense_Mutation_p.E66A|DENND5B_uc001rkk.1_5'UTR	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	44						integral to membrane				ovary(1)|central_nervous_system(1)	2						GTCAAAATTTTCGCCTACAAC	0.338													0	0	0	0.006122	0	19	63										G	31648850	T	G	31648850	3	3	43	1	0	0	0	0	1	0	0	0	4437	1783	62	5	3773	5	DENND5B	12	31648850	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	9643462	31648850	102203045	166	11273										
LARP4	113251	broad.mit.edu	37	chr12	50829280	50829280	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgttttttcagagaaaatttGtcaaaggatctttacttgat	7	4	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:50829280G>T	uc001rwp.1	+	5	552	c.408G>T	c.(406-408)TTG>TTT	p.L136F	LARP4_uc001rwo.1_Missense_Mutation_p.L142F|LARP4_uc001rwq.1_Missense_Mutation_p.L136F|LARP4_uc001rwr.1_Missense_Mutation_p.L136F|LARP4_uc001rws.1_Missense_Mutation_p.L135F|LARP4_uc009zlr.1_5'Flank|LARP4_uc001rwm.2_Missense_Mutation_p.L136F|LARP4_uc001rwn.2_Missense_Mutation_p.L66F	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	136	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(1)	1						GAGAAAATTTGTCAAAGGATC	0.313													1	0	1.42536e-11	0.004656	1.5649e-11	25	111										T	50829280	G	T	50829280	3	4	43	1	0	0	0	0	1	0	0	0	8630	1368	48	4	426	4	LARP4	12	50829280	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	19180430	50829280	83022615	167	11274										
SCN8A	6334	broad.mit.edu	37	chr12	52164425	52164425	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtggagcacaactggtttgaGaccttcatcatcttcatgat	9	9	4	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:52164425G>C	uc001ryw.2	+	19	3781	c.3603G>C	c.(3601-3603)GAG>GAC	p.E1201D	SCN8A_uc010snl.1_Missense_Mutation_p.E1066D	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1201	III.|Helical; Name=S1 of repeat III; (Potential).				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ACTGGTTTGAGACCTTCATCA	0.557													0	0	0	0.008291	0	10	133										C	52164425	G	C	52164425	3	2	43	1	0	0	0	0	1	0	0	0	13924	933	33	1	3673	1	SCN8A	12	52164425	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1335145	52164425	81687470	168	11275										
ESPL1	9700	broad.mit.edu	37	chr12	53677876	53677876	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tggtgctgaagggcgagctgGagctggcccgcaatgacatt	16	9	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:53677876G>A	uc001sck.2	+	17	3203	c.3112G>A	c.(3112-3114)GAG>AAG	p.E1038K	ESPL1_uc001scj.2_Missense_Mutation_p.E713K|ESPL1_uc010soe.1_Missense_Mutation_p.E249K	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1038					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGGCGAGCTGGAGCTGGCCCG	0.532													0	0	0	0.00361	0	79	173										A	53677876	G	A	53677876	3	1	43	1	0	0	0	0	1	0	0	0	5253	1175	41	1	3174	1	ESPL1	12	53677876	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	1513451	53677876	80174019	169	11276										
OR6C70	390327	broad.mit.edu	37	chr12	55863095	55863095	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aacaacggggcaactgaagtAttgagcacagttactccttt	9	9	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:55863095A>G	uc010spn.1	-	1	828	c.828T>C	c.(826-828)AAT>AAC	p.N276N		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CAACTGAAGTATTGAGCACAG	0.358													0	0	0	0.003163	0	16	179										G	55863095	A	G	55863095	2	3	43	1	0	0	0	0	0	0	0	1	11197	446	16	5		5	OR6C70	12	55863095	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2185219	55863095	77988800	170	11277										
AVIL	10677	broad.mit.edu	37	chr12	58197160	58197179	+	Splice_Site	DEL	ATTTCCTGCTGAAGTCTGCA	ATTTCCTGCTGAAGTCTGCA	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gacgagactggacatctaggAtttcctgctgaagtctgcaa							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:58197160_58197179delATTTCCTGCTGAAGTCTGCA	uc001sqj.1	-	15	1847	c.1818_splice	c.e15-1	p.R606_splice	AVIL_uc009zqe.1_Splice_Site_p.R599_splice|AVIL_uc001sqk.1_Splice_Site_p.R184_splice	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin						actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GACATCTAGGATTTCCTGCTGAAGTCTGCAATATAGTCCA	0.459											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						34	59	---	---								-	58197179	ATTTCCTGCTGAAGTCTGCA	-	58197160	8	5	43	1	0	1	0	1	0	0	1	0	1227	333	12	0	647	0	AVIL	12	58197160	Splice_Site	DEL	ATTTCCTGCTGAAGTCTGCA	TCGA-DK-A1A7-01A-11D-A13W-08	2334065	58197160	75654735	171	11278										
NUP107	57122	broad.mit.edu	37	chr12	69120293	69120305	+	Frame_Shift_Del	DEL	TTTAGCAAATGGC	TTTAGCAAATGGC	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttgtaggtttgatggatgagTttagcaaatggctttccaaa							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:69120293_69120305delTTTAGCAAATGGC	uc001suf.2	+	19	1706_1718	c.1591_1603delTTTAGCAAATGGC	c.(1591-1605)TTTAGCAAATGGCTTfs	p.F531fs	NUP107_uc001sug.2_Frame_Shift_Del_p.F378fs|NUP107_uc010stj.1_Frame_Shift_Del_p.F502fs	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	531_535					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			GATGGATGAGTTTAGCAAATGGCTTTCCAAAAG	0.352																		25	277	---	---								-	69120305	TTTAGCAAATGGC	-	69120293	7	5	43	1	0	1	0	1	0	0	0	0	10753	1725	60	0	1665	0	NUP107	12	69120293	Frame_Shift_Del	DEL	TTTAGCAAATGGC	TCGA-DK-A1A7-01A-11D-A13W-08	10923133	69120293	64731602	172	11279										
ZFC3H1	196441	broad.mit.edu	37	chr12	72057170	72057170	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gctgagaagaggacgatgacGaggaagagccaccgcctccg	15	11	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:72057170G>A	uc001swo.2	-	1	580	c.221C>T	c.(220-222)TCG>TTG	p.S74L	ZFC3H1_uc010sts.1_Missense_Mutation_p.S74L|ZFC3H1_uc001swp.2_Missense_Mutation_p.S74L|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	74	Ser-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GGACGATGACGAGGAAGAGCC	0.677											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	14	289										A	72057170	G	A	72057170	3	1	43	1	0	0	0	0	1	0	0	0	17630	1059	37	1	5888	1	ZFC3H1	12	72057170	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2936877	72057170	61794725	173	11280										
TRHDE	29953	broad.mit.edu	37	chr12	72680477	72680477	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccagattccttggtgttactCagttttcgcctacacatgcc	7	13	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:72680477C>T	uc001sxa.2	+	2	826	c.796C>T	c.(796-798)CAG>TAG	p.Q266*		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	266	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TGGTGTTACTCAGTTTTCGCC	0.363													0	0	0	0.00361	0	82	441										T	72680477	C	T	72680477	4	4	43	1	0	0	0	0	0	1	0	0	16476	827	29	1	802	1	TRHDE	12	72680477	Nonsense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	623307	72680477	61171418	174	11281										
TRHDE	29953	broad.mit.edu	37	chr12	72680639	72680639	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aagatggatgggttacggatCacttttcacagacccctctc	9	11	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:72680639C>T	uc001sxa.2	+	2	988	c.958C>T	c.(958-960)CAC>TAC	p.H320Y		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	320	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GGTTACGGATCACTTTTCACA	0.408													0	0	0	0.00361	0	127	531										T	72680639	C	T	72680639	3	4	43	1	0	0	0	0	1	0	0	0	16476	826	29	1	964	1	TRHDE	12	72680639	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	162	72680639	61171256	175	11282										
TMPO	7112	broad.mit.edu	37	chr12	98925604	98925604	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atgattctgacagatacagtGacaatgaagaaggtaaaatt	9	4	1	6			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:98925604G>C	uc001tfj.2	+	3	790	c.553G>C	c.(553-555)GAC>CAC	p.D185H	TMPO_uc001tfi.1_Missense_Mutation_p.D185H|TMPO_uc001tfk.2_Missense_Mutation_p.D185H|TMPO_uc001tfl.2_RNA|TMPO_uc001tfh.1_Missense_Mutation_p.D185H	NM_001032283	NP_001027454	P42167	LAP2B_HUMAN	thymopoietin isoform beta	185	Nucleoplasmic (Potential).|NAKAP95-binding N.					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			ovary(2)	2						CAGATACAGTGACAATGAAGA	0.313													0	0	0	0.009535	0	29	35										C	98925604	G	C	98925604	3	2	43	1	0	0	0	0	1	0	0	0	16234	1290	45	1	563	1	TMPO	12	98925604	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	26244965	98925604	34926291	176	11283										
NUAK1	9891	broad.mit.edu	37	chr12	106500253	106500253	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atctctcgtctgatgtgaacCatgtcttgttcatccttaat	6	10	4	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:106500253C>A	uc001tlj.1	-	2	1671	c.291G>T	c.(289-291)ATG>ATT	p.M97I		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	97	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						TGATGTGAACCATGTCTTGTT	0.343													1	0	0.000375601	0.00278	0.000386684	25	5										A	106500253	C	A	106500253	3	1	43	1	0	0	0	0	1	0	0	0	10712	594	21	4	1718	4	NUAK1	12	106500253	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	7574649	106500253	27351642	177	11284										
CUX2	23316	broad.mit.edu	37	chr12	111758093	111758093	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cccgcgcaggcgccgctcccGgtcctgtcccccgccgcctt	11	23	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:111758093G>T	uc001tsa.1	+	17	2433	c.2280G>T	c.(2278-2280)CCG>CCT	p.P760P		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	760						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CGCCGCTCCCGGTCCTGTCCC	0.736													1	0	1.58986e-06	0.008291	1.66962e-06	11	16										T	111758093	G	T	111758093	2	4	43	1	0	0	0	0	0	0	0	1	4065	1103	39	4		4	CUX2	12	111758093	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	5257840	111758093	22093802	178	11285										
TBX5	6910	broad.mit.edu	37	chr12	114836462	114836462	+	Frame_Shift_Del	DEL	G	G	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atccaatgcgccccggtggcGggggagtctgggtgcacgta							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:114836462delG	uc001tvo.2	-	5	921	c.426delC	c.(424-426)CCCfs	p.P142fs	TBX5_uc001tvp.2_Frame_Shift_Del_p.P142fs|TBX5_uc001tvq.2_Frame_Shift_Del_p.P92fs|TBX5_uc010syv.1_Frame_Shift_Del_p.P142fs	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	142	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CCCCGGTGGCGGGGGAGTCTG	0.612																		18	22	---	---								-	114836462	G	-	114836462	7	5	43	1	0	1	0	1	0	0	0	0	15658	1103	39	0	1217	0	TBX5	12	114836462	Frame_Shift_Del	DEL	G	TCGA-DK-A1A7-01A-11D-A13W-08	3078369	114836462	19015433	179	11286										
HPD	3242	broad.mit.edu	37	chr12	122281692	122281692	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gcagttgtttgtagtacgtgGagggaacagataagaactcc	13	6	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:122281692G>A	uc001ubj.2	-	12	918	c.878C>T	c.(877-879)TCC>TTC	p.S293F	HPD_uc001ubk.2_Missense_Mutation_p.S254F	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	293					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	GTAGTACGTGGAGGGAACAGA	0.542													0	0	0	0.012319	0	22	29										A	122281692	G	A	122281692	3	1	43	1	0	0	0	0	1	0	0	0	7332	1174	41	1	315	1	HPD	12	122281692	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	7445230	122281692	11570203	180	11287										
RIMBP2	23504	broad.mit.edu	37	chr12	130912840	130912840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtctgagaggtcagacccccGgctgctctctgtgtggtact	13	12	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr12:130912840G>A	uc001uil.2	-	12	2409	c.2245C>T	c.(2245-2247)CGG>TGG	p.R749W		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	749						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TCAGACCCCCGGCTGCTCTCT	0.617													0	0	0	0.004007	0	14	45										A	130912840	G	A	130912840	3	1	43	1	0	0	0	0	1	0	0	0	13363	1115	39	2	945	2	RIMBP2	12	130912840	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	8631148	130912840	2939055	181	11288										
PCDH9	5101	broad.mit.edu	37	chr13	67802415	67802415	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cgctggtccctgtggcagcaTtgatgtgagaaatgttcaga	13	8	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr13:67802415T>C	uc001vik.2	-	2	850	c.158A>G	c.(157-159)AAT>AGT	p.N53S	PCDH9_uc001vil.2_Missense_Mutation_p.N53S|PCDH9_uc010thl.1_Missense_Mutation_p.N53S|PCDH9_uc001vin.3_Missense_Mutation_p.N53S	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	53	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TGTGGCAGCATTGATGTGAGA	0.458													0	0	0	0.003954	0	24	12										C	67802415	T	C	67802415	3	2	43	1	0	0	0	0	1	0	0	0	11518	1493	52	5	3571	5	PCDH9	13	67802415	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08		67802415	47367463	182	11289										
REC8	9985	broad.mit.edu	37	chr14	24648917	24648917	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agagctcgagctgctctcacTggaagcagtgcacaggtacc	12	12	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr14:24648917T>G	uc001wmr.2	+	19	1863	c.1436T>G	c.(1435-1437)CTG>CGG	p.L479R	REC8_uc001wms.2_Missense_Mutation_p.L479R	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	479	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		CTGCTCTCACTGGAAGCAGTG	0.612													0	0	0	0.003954	0	26	48										G	24648917	T	G	24648917	3	3	43	1	0	0	0	0	1	0	0	0	13199	1580	55	5	1499	5	REC8	14	24648917	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08		24648917	82700623	183	11290										
CTSG	1511	broad.mit.edu	37	chr14	25043947	25043947	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggtggcggatggctctgcgCgcagtgatgtgttgctgggt	20	7	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr14:25043947C>T	uc001wpq.2	-	3	310	c.273G>A	c.(271-273)GCG>GCA	p.A91A		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	91	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TGGCTCTGCGCGCAGTGATGT	0.532													0	0	0	0.003954	0	25	69										T	25043947	C	T	25043947	2	4	43	1	0	0	0	0	0	0	0	1	4035	755	27	2		2	CTSG	14	25043947	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	395030	25043947	82305593	184	11291										
TRIM9	114088	broad.mit.edu	37	chr14	51561002	51561002	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccttgcgtgggctcagcctcCggctcacacgaccctgggcc	12	18	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr14:51561002C>T	uc001wyx.3	-	1	1421	c.656G>A	c.(655-657)CGG>CAG	p.R219Q	TRIM9_uc001wyy.2_Missense_Mutation_p.R219Q|TRIM9_uc001wyz.3_Missense_Mutation_p.R219Q	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	219					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					GCTCAGCCTCCGGCTCACACG	0.672													0	0	0	0.00308	0	8	22										T	51561002	C	T	51561002	3	4	43	1	0	0	0	0	1	0	0	0	16546	652	23	2	1566	2	TRIM9	14	51561002	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	26517055	51561002	55788538	185	11292										
PLEKHG3	26030	broad.mit.edu	37	chr14	65197535	65197535	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agctccgtggccgccctgacGgaatgcatgcgggacaagca	14	13	0	1	rs144144480		TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr14:65197535G>T	uc001xho.1	+	6	854	c.585G>T	c.(583-585)ACG>ACT	p.T195T	PLEKHG3_uc001xhn.1_Silent_p.T139T|PLEKHG3_uc001xhp.2_Silent_p.T195T|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	195	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CCGCCCTGACGGAATGCATGC	0.642													1	0	4.93089e-13	0.00245	5.47102e-13	13	15										T	65197535	G	T	65197535	2	4	43	1	0	0	0	0	0	0	0	1	12070	1103	39	4		4	PLEKHG3	14	65197535	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	13636533	65197535	42152005	186	11293										
C14orf181	400223	broad.mit.edu	37	chr14	69262557	69262557	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggagccgagaggagggagcGagtcccttaacccttcgctg	16	11	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr14:69262557G>C	uc001xkj.1	-	1	634	c.455C>G	c.(454-456)TCG>TGG	p.S152W	ZFP36L1_uc001xkh.1_5'Flank|ZFP36L1_uc001xki.1_5'Flank	NM_207442	NP_997325			hypothetical protein LOC400223												0				all cancers(60;0.002)|BRCA - Breast invasive adenocarcinoma(234;0.00204)|OV - Ovarian serous cystadenocarcinoma(108;0.0399)		AGGAGGGAGCGAGTCCCTTAA	0.617													0	0	0	0.00874	0	27	31										C	69262557	G	C	69262557	3	2	43	1	0	0	0	0	1	0	0	0	1764	1059	37	1	49	1	C14orf181	14	69262557	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	4065022	69262557	38086983	187	11294										
C14orf45	80127	broad.mit.edu	37	chr14	74489638	74489638	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggaagttaataaaaacagatGaatctgtggtggacagagcc	12	5	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr14:74489638G>A	uc010tup.1	+	2	199	c.76G>A	c.(76-78)GAA>AAA	p.E26K		NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	26											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		AAAAACAGATGAATCTGTGGT	0.388													0	0	0	0.00308	0	8	16										A	74489638	G	A	74489638	3	1	43	1	0	0	0	0	1	0	0	0	1775	1291	45	1	82	1	C14orf45	14	74489638	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	5227081	74489638	32859902	188	11295										
HERC2	8924	broad.mit.edu	37	chr15	28467360	28467360	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcaacgttgtcacaactgggGcctgatggagcgtcaaaaac	11	10	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:28467360G>A	uc001zbj.2	-	36	5572	c.5466C>T	c.(5464-5466)GGC>GGT	p.G1822G		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1822					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CACAACTGGGGCCTGATGGAG	0.443													0	0	0	0.004007	0	16	29										A	28467360	G	A	28467360	2	1	43	1	0	0	0	0	0	0	0	1	7058	1217	42	2		2	HERC2	15	28467360	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08		28467360	74064032	189	11296										
FBN1	2200	broad.mit.edu	37	chr15	48752456	48752456	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gactcaccaacgggtaaaccGgtataaatgtcgatgacaaa	9	9	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:48752456G>C	uc001zwx.1	-	43	5611	c.5283C>G	c.(5281-5283)ACC>ACG	p.T1761T	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1761					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CGGGTAAACCGGTATAAATGT	0.418													0	0	0	0.00499	0	15	21										C	48752456	G	C	48752456	2	2	43	1	0	0	0	0	0	0	0	1	5702	1103	39	4		4	FBN1	15	48752456	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	20285096	48752456	53778936	190	11297										
FBN1	2200	broad.mit.edu	37	chr15	48787780	48787780	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggacttgattcgcattcatCaatgtctgaaacaaaaacag	7	8	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:48787780C>T	uc001zwx.1	-	21	2753	c.2425G>A	c.(2425-2427)GAT>AAT	p.D809N		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	809	EGF-like 13; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TCGCATTCATCAATGTCTGAA	0.378													0	0	0	0.00361	0	64	99										T	48787780	C	T	48787780	3	4	43	1	0	0	0	0	1	0	0	0	5702	826	29	1	6374	1	FBN1	15	48787780	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	35324	48787780	53743612	191	11298										
SECISBP2L	9728	broad.mit.edu	37	chr15	49309824	49309824	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gttcttgaaacccatcttcaTcctgaaatgtttcacatttt	4	10	4	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:49309824T>A	uc001zxe.1	-	9	1306	c.1172A>T	c.(1171-1173)GAT>GTT	p.D391V	SECISBP2L_uc001zxd.1_Missense_Mutation_p.D346V|SECISBP2L_uc010bep.1_Missense_Mutation_p.D153V|SECISBP2L_uc010beq.1_Missense_Mutation_p.D263V	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	391										breast(1)|skin(1)	2						CCCATCTTCATCCTGAAATGT	0.284													0	0	0	0.000602	0	5	18										A	49309824	T	A	49309824	3	1	43	1	0	0	0	0	1	0	0	0	14007	1449	50	5	2173	5	SECISBP2L	15	49309824	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	522044	49309824	53221568	192	11299										
DPP8	54878	broad.mit.edu	37	chr15	65790284	65790284	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttgctatgtataaaagcaatCcagtctggatcagcagggca	10	8	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:65790284C>G	uc002aov.2	-	5	2259	c.681G>C	c.(679-681)TGG>TGC	p.W227C	DPP8_uc002aow.2_Missense_Mutation_p.W227C|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.W211C|DPP8_uc002aoy.2_Missense_Mutation_p.W227C|DPP8_uc002aoz.2_Missense_Mutation_p.W211C|DPP8_uc010bhj.2_Missense_Mutation_p.W227C|DPP8_uc002apa.2_Missense_Mutation_p.W124C	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	227					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						TAAAAGCAATCCAGTCTGGAT	0.403													0	0	0	0.010818	0	33	34										G	65790284	C	G	65790284	3	3	43	1	0	0	0	0	1	0	0	0	4732	856	30	1	2079	1	DPP8	15	65790284	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	16480460	65790284	36741108	193	11300										
MYO9A	4649	broad.mit.edu	37	chr15	72193566	72193566	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atgcttgtctcagatggaggAaatgctgcctacacagcaag	11	9	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:72193566A>G	uc002atl.3	-	23	3589	c.3116T>C	c.(3115-3117)TTC>TCC	p.F1039S	MYO9A_uc010biq.2_Missense_Mutation_p.F659S|MYO9A_uc002atn.1_Missense_Mutation_p.F1020S|MYO9A_uc002atk.2_5'Flank|MYO9A_uc002atm.1_5'Flank	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1039	IQ 1.|Neck or regulatory domain.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CAGATGGAGGAAATGCTGCCT	0.443													0	0	0	0.010504	0	21	26										G	72193566	A	G	72193566	3	3	43	1	0	0	0	0	1	0	0	0	10084	246	9	5	4610	5	MYO9A	15	72193566	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	6403282	72193566	30337826	194	11301										
PML	5371	broad.mit.edu	37	chr15	74315653	74315653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tctgccgcctgcgccaggagGagccccagagcctgcaagct	13	16	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:74315653G>A	uc002awv.2	+	3	1227	c.1087G>A	c.(1087-1089)GAG>AAG	p.E363K	PML_uc002awm.2_Missense_Mutation_p.E363K|PML_uc002awl.2_Missense_Mutation_p.E363K|PML_uc002awj.1_Missense_Mutation_p.E363K|PML_uc002awk.2_Missense_Mutation_p.E363K|PML_uc002awn.2_Missense_Mutation_p.E363K|PML_uc002awo.2_Missense_Mutation_p.E363K|PML_uc002awp.2_Missense_Mutation_p.E363K|PML_uc002awq.2_Missense_Mutation_p.E363K|PML_uc002awr.2_Missense_Mutation_p.E363K|PML_uc002aws.2_Missense_Mutation_p.E363K|PML_uc002awt.2_Missense_Mutation_p.E363K|PML_uc002awu.2_Missense_Mutation_p.E363K|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.E278K|PML_uc002awx.2_Missense_Mutation_p.E121K|PML_uc002awy.2_5'Flank	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	363					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						GCGCCAGGAGGAGCCCCAGAG	0.652			T	RARA|PAX5	APL|ALL								0	0	0	0.004007	0	9	20										A	74315653	G	A	74315653	3	1	43	1	0	0	0	0	1	0	0	0	12135	1175	41	1	1097	1	PML	15	74315653	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2122087	74315653	28215739	195	11302										
SCAPER	49855	broad.mit.edu	37	chr15	76994116	76994116	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	taccacttcttcatctgacaGttcacgcccctggatgctgg	8	14	4	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:76994116G>A	uc002bby.2	-	19	2550	c.2491C>T	c.(2491-2493)CTG>TTG	p.L831L	SCAPER_uc010bkr.2_Silent_p.L139L|SCAPER_uc002bbx.2_Silent_p.L585L|SCAPER_uc002bbz.1_Silent_p.L702L|SCAPER_uc002bca.1_Silent_p.L696L	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	830						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						TCATCTGACAGTTCACGCCCC	0.373													0	0	0	0.003755	0	33	21										A	76994116	G	A	76994116	2	1	43	1	0	0	0	0	0	0	0	1	13878	1020	36	2		2	SCAPER	15	76994116	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2678463	76994116	25537276	196	11303										
MORF4L1	10933	broad.mit.edu	37	chr15	79187188	79187188	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttggagcaatgttggcttatAcacctctggatgagaagagc	12	7	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:79187188A>T	uc002bel.2	+	12	1134	c.946A>T	c.(946-948)ACA>TCA	p.T316S	MORF4L1_uc002bem.2_Missense_Mutation_p.T277S|MORF4L1_uc010une.1_Missense_Mutation_p.T189S	NM_206839	NP_996670	Q9UBU8	MO4L1_HUMAN	MORF-related gene 15 isoform 2	316	Sufficient for interaction with PHF12.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding				0						GTTGGCTTATACACCTCTGGA	0.343													0	0	0	0.003755	0	36	43										T	79187188	A	T	79187188	3	4	43	1	0	0	0	0	1	0	0	0	9706	391	14	5	992	5	MORF4L1	15	79187188	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	2193072	79187188	23344204	197	11304										
ANPEP	290	broad.mit.edu	37	chr15	90348650	90348650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gctcatcgaagcatgggaagGacttccgggcatctgcagcc	13	12	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:90348650G>A	uc002bop.3	-	3	951	c.659C>T	c.(658-660)TCC>TTC	p.S220F		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	220	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCATGGGAAGGACTTCCGGGC	0.602													0	0	0	0.010504	0	20	14										A	90348650	G	A	90348650	3	1	43	1	0	0	0	0	1	0	0	0	710	1174	41	1	2320	1	ANPEP	15	90348650	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	11161462	90348650	12182742	198	11305										
ZNF710	374655	broad.mit.edu	37	chr15	90611334	90611334	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggccacaacggcatcaagcCacactcgtgcccacactgca	9	17	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:90611334C>A	uc002bov.1	+	2	1088	c.965C>A	c.(964-966)CCA>CAA	p.P322Q		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GGCATCAAGCCACACTCGTGC	0.637													1	0	0.000978159	0.010729	0.00100373	9	22										A	90611334	C	A	90611334	3	1	43	1	0	0	0	0	1	0	0	0	18112	594	21	4	967	4	ZNF710	15	90611334	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	262684	90611334	11920058	199	11306										
BLM	641	broad.mit.edu	37	chr15	91290711	91290711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	taaattaagtctttcaaaacCaaaattttcgtaagtgtttt	4	5	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr15:91290711C>T	uc002bpr.2	+	2	186	c.89C>T	c.(88-90)CCA>CTA	p.P30L	BLM_uc010uqh.1_Missense_Mutation_p.P30L|BLM_uc010uqi.1_5'UTR|BLM_uc010bnx.2_Missense_Mutation_p.P30L	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	30					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CTTTCAAAACCAAAATTTTCG	0.294			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				0	0	0	0.001984	0	7	13										T	91290711	C	T	91290711	3	4	43	1	0	0	0	0	1	0	0	0	1445	594	21	2	91	2	BLM	15	91290711	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	679377	91290711	11240681	200	11307										
C16orf11	146325	broad.mit.edu	37	chr16	613383	613383	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gccacactacatcccgcggcCctggggcaaaccctacaact	8	18	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:613383C>G	uc002chk.2	+	2	368	c.89C>G	c.(88-90)CCC>CGC	p.P30R		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	30										central_nervous_system(1)	1						ATCCCGCGGCCCTGGGGCAAA	0.622													0	0	0	0.001368	0	10	10										G	613383	C	G	613383	3	3	43	1	0	0	0	0	1	0	0	0	1810	623	22	4	91	4	C16orf11	16	613383	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		613383	89741370	201	11308										
LMF1	64788	broad.mit.edu	37	chr16	919947	919947	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acggggagatgaggcagggcCgtctgctggggtcacctggc	19	10	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:919947C>T	uc002ckj.2	-	9	1356	c.1352G>A	c.(1351-1353)CGG>CAG	p.R451Q	LMF1_uc010brg.2_5'Flank|LMF1_uc010brh.2_Missense_Mutation_p.R234Q|LMF1_uc010bri.2_Missense_Mutation_p.R214Q|LMF1_uc002ckk.2_Missense_Mutation_p.R234Q	NM_022773	NP_073610	Q96S06	LMF1_HUMAN	lipase maturation factor 1	451	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Hepatocellular(780;0.00308)				GAGGCAGGGCCGTCTGCTGGG	0.672													0	0	0	0.001368	0	10	7										T	919947	C	T	919947	3	4	43	1	0	0	0	0	1	0	0	0	8845	652	23	2	363	2	LMF1	16	919947	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	306564	919947	89434806	202	11309										
USP31	57478	broad.mit.edu	37	chr16	23116802	23116802	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttccatagacactgcttccCgaagtctggcgacagtccca	8	14	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:23116802C>G	uc002dll.2	-	5	1049	c.1049G>C	c.(1048-1050)CGG>CCG	p.R350P		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	350					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CACTGCTTCCCGAAGTCTGGC	0.468													0	0	0	0.009535	0	27	51										G	23116802	C	G	23116802	3	3	43	1	0	0	0	0	1	0	0	0	17059	652	23	4	3057	4	USP31	16	23116802	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	22196855	23116802	67237951	203	11310										
COG7	91949	broad.mit.edu	37	chr16	23445959	23445959	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcgcgcacagcttcttacctTgtgacacttgtagtagtagg	10	10	1	1	rs140030187		TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:23445959T>C	uc002dlo.2	-	5	873	c.685A>G	c.(685-687)AAG>GAG	p.K229E		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	229					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		CTTCTTACCTTGTGACACTTG	0.433											OREG0023684	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	21	33										C	23445959	T	C	23445959	3	2	43	1	0	0	0	0	1	0	0	0	3663	1821	63	5	1679	5	COG7	16	23445959	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	329157	23445959	66908794	204	11311										
PLK1	5347	broad.mit.edu	37	chr16	23700964	23700964	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agcgccatcatcctgcacctCagcaacggcagcgtgcagat	10	15	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:23700964C>T	uc002dlz.1	+	9	1628	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	525	POLO box 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		TCCTGCACCTCAGCAACGGCA	0.652													0	0	0	0.003163	0	13	13										T	23700964	C	T	23700964	2	4	43	1	0	0	0	0	0	0	0	1	12094	813	29	1		1	PLK1	16	23700964	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	255005	23700964	66653789	205	11312										
SH2B1	25970	broad.mit.edu	37	chr16	28878329	28878329	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agaaggaggaggaggaagtcGcctggagttctttgtaccac	15	7	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:28878329G>T	uc002dri.2	+	4	1353	c.914G>T	c.(913-915)CGC>CTC	p.R305L	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.R305L|SH2B1_uc002drk.2_Missense_Mutation_p.R305L|SH2B1_uc002drl.2_Missense_Mutation_p.R305L|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.R305L|SH2B1_uc002drm.2_Missense_Mutation_p.R305L	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	305	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|PH.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGAGGAAGTCGCCTGGAGTTC	0.607													1	0	2.32416e-17	0.002299	2.61572e-17	23	25										T	28878329	G	T	28878329	3	4	43	1	0	0	0	0	1	0	0	0	14227	1087	38	4	916	4	SH2B1	16	28878329	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	5177365	28878329	61476424	206	11313										
ZNF768	79724	broad.mit.edu	37	chr16	30537683	30537692	+	Frame_Shift_Del	DEL	AACTCTGCAC	AACTCTGCAC	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggggctcctcatttcgtcagAactctgcacatcctggggct					rs145753318		TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:30537683_30537692delAACTCTGCAC	uc002dyk.3	-	1	219_228	c.43_52delGTGCAGAGTT	c.(43-54)GTGCAGAGTTCTfs	p.V15fs	ZNF768_uc010vex.1_Intron|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Intron	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	15_18					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						ATTTCGTCAGAACTCTGCACATCCTGGGGC	0.714																		7	28	---	---								-	30537692	AACTCTGCAC	-	30537683	7	5	43	1	0	1	0	1	0	0	0	0	18138	246	9	0	1578	0	ZNF768	16	30537683	Frame_Shift_Del	DEL	AACTCTGCAC	TCGA-DK-A1A7-01A-11D-A13W-08	1659354	30537683	59817070	207	11314										
VKORC1	79001	broad.mit.edu	37	chr16	31102541	31102541	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gttgatagcataggtggtgaTacaaacaatgcagaaatcat	10	5	1	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:31102541T>C	uc002eas.2	-	3	632	c.406A>G	c.(406-408)ATC>GTC	p.I136V	PRSS53_uc002eaq.2_5'Flank|PRSS53_uc002ear.2_5'UTR|VKORC1_uc002eat.2_3'UTR|VKORC1_uc002eau.2_3'UTR	NM_024006	NP_076869	Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1	136	Helical; (Potential).				peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	vitamin-K-epoxide reductase (warfarin-sensitive) activity				0					Acenocoumarol(DB01418)|Dicumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	TAGGTGGTGATACAAACAATG	0.537													0	0	0	0.010729	0	12	69										C	31102541	T	C	31102541	3	2	43	1	0	0	0	0	1	0	0	0	17169	1406	49	5	89	5	VKORC1	16	31102541	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	564858	31102541	59252212	208	11315										
CNGB1	1258	broad.mit.edu	37	chr16	57935276	57935276	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cttcttgcacacatagtcgtTgggcaggtagacaacagagc	11	10	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:57935276T>A	uc002emt.2	-	29	3021	c.2956A>T	c.(2956-2958)AAC>TAC	p.N986Y	CNGB1_uc010cdh.2_Missense_Mutation_p.N980Y	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	986	Cytoplasmic (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						ACATAGTCGTTGGGCAGGTAG	0.567													0	0	0	0.009535	0	29	68										A	57935276	T	A	57935276	3	1	43	1	0	0	0	0	1	0	0	0	3600	1812	63	5	819	5	CNGB1	16	57935276	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	26832735	57935276	32419477	209	11316										
RLTPR	146206	broad.mit.edu	37	chr16	67679643	67679643	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccaggcactgctacgatggaGagcctacctgctgcacacca	10	15	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:67679643G>A	uc002etn.2	+	3	269	c.149G>A	c.(148-150)AGA>AAA	p.R50K	RLTPR_uc010cel.1_Missense_Mutation_p.R50K|RLTPR_uc010vjr.1_Missense_Mutation_p.R50K	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	50										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CTACGATGGAGAGCCTACCTG	0.667													0	0	0	0.010818	0	32	29										A	67679643	G	A	67679643	3	1	43	1	0	0	0	0	1	0	0	0	13394	942	33	1	159	1	RLTPR	16	67679643	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	9744367	67679643	22675110	210	11317										
NFAT5	10725	broad.mit.edu	37	chr16	69725894	69725908	+	In_Frame_Del	DEL	ATTGCAGCAGGCTAC	ATTGCAGCAGGCTAC	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctgcccaacagcgatgcactAttgcagcaggctacacagtt							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:69725894_69725908delATTGCAGCAGGCTAC	uc002exm.1	+	12	3320_3334	c.2112_2126delATTGCAGCAGGCTAC	c.(2110-2127)CTATTGCAGCAGGCTACA>CTA	p.LQQAT705del	NFAT5_uc002exi.2_In_Frame_Del_p.LQQAT629del|NFAT5_uc002exj.1_In_Frame_Del_p.LQQAT629del|NFAT5_uc002exk.1_In_Frame_Del_p.LQQAT629del|NFAT5_uc002exl.1_In_Frame_Del_p.LQQAT723del|NFAT5_uc002exn.1_In_Frame_Del_p.LQQAT722del|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	705_709					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GCGATGCACTATTGCAGCAGGCTACACAGTTTCAG	0.465																		13	65	---	---								-	69725908	ATTGCAGCAGGCTAC	-	69725894	7	5	43	1	0	1	0	1	0	0	0	0	10360	436	16	0	2216	0	NFAT5	16	69725894	In_Frame_Del	DEL	ATTGCAGCAGGCTAC	TCGA-DK-A1A7-01A-11D-A13W-08	2046251	69725894	20628859	211	11318										
WWP2	11060	broad.mit.edu	37	chr16	69959346	69959346	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgtttagtcttcgagtgcttCgactgaccatgatcccctgg	10	11	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:69959346C>T	uc002exu.1	+	12	1282	c.1193C>T	c.(1192-1194)TCG>TTG	p.S398L	WWP2_uc002exv.1_Missense_Mutation_p.S398L|WWP2_uc010vlm.1_Missense_Mutation_p.S282L|WWP2_uc010vln.1_Missense_Mutation_p.S16L|WWP2_uc002exw.1_5'UTR	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	398					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						TCGAGTGCTTCGACTGACCAT	0.488													0	0	0	0.00361	0	242	221										T	69959346	C	T	69959346	3	4	43	1	0	0	0	0	1	0	0	0	17413	893	31	1	1235	1	WWP2	16	69959346	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	233452	69959346	20395407	212	11319										
ZNF23	7571	broad.mit.edu	37	chr16	71483770	71483770	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	acatttcctttgtcaaatcaTtgtcagtctgaatatctact	4	9	5	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:71483770T>A	uc002faf.2	-	6	972	c.158A>T	c.(157-159)AAT>ATT	p.N53I	ZNF23_uc002fad.2_5'UTR|ZNF23_uc002fae.2_5'UTR|ZNF23_uc010vmf.1_5'UTR|ZNF23_uc002fag.2_5'UTR|ZNF23_uc002fah.2_Missense_Mutation_p.N53I|ZNF23_uc002fai.2_Missense_Mutation_p.N92I	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TGTCAAATCATTGTCAGTCTG	0.318													0	0	0	0.00245	0	14	36										A	71483770	T	A	71483770	3	1	43	1	0	0	0	0	1	0	0	0	17780	1493	52	5	1777	5	ZNF23	16	71483770	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	1524424	71483770	18870983	213	11320										
RFWD3	55159	broad.mit.edu	37	chr16	74685992	74685992	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggctgggtcctgctcacctGaaagtaagcatccaatggtg	12	10	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:74685992G>A	uc002fda.2	-	3	645	c.547C>T	c.(547-549)CAG>TAG	p.Q183*	RFWD3_uc010cgq.2_Nonsense_Mutation_p.Q183*	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	183					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTGCTCACCTGAAAGTAAGCA	0.413													0	0	0	0.00245	0	13	35										A	74685992	G	A	74685992	4	1	43	1	0	0	0	0	0	1	0	0	13261	1299	45	1	1821	1	RFWD3	16	74685992	Nonsense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	3202222	74685992	15668761	214	11321										
PKD1L2	114780	broad.mit.edu	37	chr16	81232612	81232624	+	Frame_Shift_Del	DEL	GGGTGGTGGACTC	GGGTGGTGGACTC	-													0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gtacggtagcgagcccttttGggtggtggactcggccaggg							TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:81232612_81232624delGGGTGGTGGACTC	uc002fgh.1	-	7	1186_1198	c.1186_1198delGAGTCCACCACCC	c.(1186-1200)GAGTCCACCACCCAAfs	p.E396fs	PKD1L2_uc002fgj.2_Frame_Shift_Del_p.E396fs	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	396_400	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GAGCCCTTTTGGGTGGTGGACTCGGCCAGGGTT	0.516																		15	84	---	---								-	81232624	GGGTGGTGGACTC	-	81232612	7	5	43	1	0	1	0	1	0	0	0	0	11965	1357	47	0	6398	0	PKD1L2	16	81232612	Frame_Shift_Del	DEL	GGGTGGTGGACTC	TCGA-DK-A1A7-01A-11D-A13W-08	6546620	81232612	9122141	215	11322										
ZFPM1	161882	broad.mit.edu	37	chr16	88555534	88555534	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aacccaggcccacggaggaaGagccgggcagtccctggagc	15	14	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:88555534G>A	uc002fkv.2	+	3	274	c.241G>A	c.(241-243)GAG>AAG	p.E81K		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	81					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CACGGAGGAAGAGCCGGGCAG	0.711													0	0	0	0.004672	0	3	7										A	88555534	G	A	88555534	3	1	43	1	0	0	0	0	1	0	0	0	17654	943	33	1	251	1	ZFPM1	16	88555534	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	7322922	88555534	1799219	216	11323										
ANKRD11	29123	broad.mit.edu	37	chr16	89345686	89345686	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctcgatggcatccagcttgaTggcgtccacgatggcggcca	13	13	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:89345686T>C	uc002fmx.1	-	9	7725	c.7264A>G	c.(7264-7266)ATC>GTC	p.I2422V	ANKRD11_uc002fmy.1_Missense_Mutation_p.I2422V|ANKRD11_uc002fnc.1_Missense_Mutation_p.I2422V|ANKRD11_uc002fna.1_Missense_Mutation_p.I87V|ANKRD11_uc002fnb.1_Missense_Mutation_p.I2379V	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2422						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCCAGCTTGATGGCGTCCACG	0.607													0	0	0	0.001984	0	3	4										C	89345686	T	C	89345686	3	2	43	1	0	0	0	0	1	0	0	0	639	1464	51	5	747	5	ANKRD11	16	89345686	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	790152	89345686	1009067	217	11324										
DPEP1	1800	broad.mit.edu	37	chr16	89702959	89702959	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggcattcggcaggccttccGggaagggaaggtggccagcc	17	11	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr16:89702959G>T	uc010cin.2	+	5	592	c.389G>T	c.(388-390)CGG>CTG	p.R130L	DPEP1_uc002fnr.3_Missense_Mutation_p.R130L|DPEP1_uc002fns.3_Missense_Mutation_p.R130L	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	130					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CAGGCCTTCCGGGAAGGGAAG	0.662													1	0	0.00621372	0.006214	0.00633476	9	23										T	89702959	G	T	89702959	3	4	43	1	0	0	0	0	1	0	0	0	4713	1116	39	4	403	4	DPEP1	16	89702959	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	357273	89702959	651794	218	11325										
MED9	55090	broad.mit.edu	37	chr17	17394774	17394774	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atgagcttctgcaaaagtacAagagcctctgcatgttcgaa	9	9	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:17394774A>T	uc002grh.1	+	2	462	c.406A>T	c.(406-408)AAG>TAG	p.K136*		NM_018019	NP_060489	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	136	Potential.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding				0						GCAAAAGTACAAGAGCCTCTG	0.567													0	0	0	0.00278	0	22	66										T	17394774	A	T	17394774	4	4	43	1	0	0	0	0	0	1	0	0	9454	131	5	5	412	5	MED9	17	17394774	Nonsense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08		17394774	63800436	219	11326										
MYO15A	51168	broad.mit.edu	37	chr17	18035826	18035826	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctggccgggttgcctgcccaGctcaggcaggcctttagcct	13	15	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:18035826G>C	uc010vxh.1	+	10	4604	c.4266G>C	c.(4264-4266)CAG>CAC	p.Q1422H		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1422	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGCCTGCCCAGCTCAGGCAGG	0.582													0	0	0	0.001368	0	12	57										C	18035826	G	C	18035826	3	2	43	1	0	0	0	0	1	0	0	0	10063	962	34	4	4300	4	MYO15A	17	18035826	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	641052	18035826	63159384	220	11327										
LASP1	3927	broad.mit.edu	37	chr17	37026461	37026461	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccatgaaccccaactgcgccCggtgcggcaagatcgtgtat	11	14	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:37026461C>G	uc002hra.2	+	1	350	c.19C>G	c.(19-21)CGG>GGG	p.R7G	LASP1_uc010wdy.1_Missense_Mutation_p.R7G|LASP1_uc010cvq.2_5'UTR|LASP1_uc010wdz.1_5'UTR	NM_006148	NP_006139	Q14847	LASP1_HUMAN	LIM and SH3 protein 1	7	LIM zinc-binding.					cortical actin cytoskeleton	ion transmembrane transporter activity|SH3/SH2 adaptor activity|zinc ion binding			lung(1)	1						CAACTGCGCCCGGTGCGGCAA	0.672			T	MLL	AML								0	0	0	0.00499	0	15	12										G	37026461	C	G	37026461	3	3	43	1	0	0	0	0	1	0	0	0	8637	643	23	4	21	4	LASP1	17	37026461	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	18990635	37026461	44168749	221	11328										
KRTAP4-9	100132386	broad.mit.edu	37	chr17	39261768	39261768	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gaccacctgctgccgccccaGctgttgtgtatccagctgct	10	16	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:39261768G>A	uc010wfp.1	+	1	128	c.128G>A	c.(127-129)AGC>AAC	p.S43N		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	43	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].|4.					keratin filament					0						TGCCGCCCCAGCTGTTGTGTA	0.652													0	0	0	0.006214	0	8	29										A	39261768	G	A	39261768	3	1	43	1	0	0	0	0	1	0	0	0	8557	971	34	2	130	2	KRTAP4-9	17	39261768	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2235307	39261768	41933442	222	11329										
SLC4A1	6521	broad.mit.edu	37	chr17	42337895	42337895	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggaggtctcttgcaggtctAggaggacagtacctgcaggc	16	9	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:42337895A>G	uc002igf.3	-	6	511	c.362T>C	c.(361-363)CTA>CCA	p.L121P	SLC4A1_uc002igg.3_Missense_Mutation_p.L121P	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	121	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TTGCAGGTCTAGGAGGACAGT	0.597													0	0	0	0.001855	0	13	47										G	42337895	A	G	42337895	3	3	43	1	0	0	0	0	1	0	0	0	14650	420	15	5	2433	5	SLC4A1	17	42337895	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	3076127	42337895	38857315	223	11330										
TRIM25	7706	broad.mit.edu	37	chr17	54985878	54985878	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	catccagtgctctcgacgccCcgttgatctgactgtacatg	9	14	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:54985878C>G	uc002iut.2	-	2	704	c.644G>C	c.(643-645)GGG>GCG	p.G215A	TRIM25_uc010dcj.2_Missense_Mutation_p.G7A	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	215	Interaction with influenza A virus NS1.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					TCTCGACGCCCCGTTGATCTG	0.582													0	0	0	0.00361	0	48	69										G	54985878	C	G	54985878	3	3	43	1	0	0	0	0	1	0	0	0	16496	623	22	4	1280	4	TRIM25	17	54985878	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	12647983	54985878	26209332	224	11331										
RAD51C	5889	broad.mit.edu	37	chr17	56774141	56774141	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	attgatacagagggaagtttTatggttgatagagtggtaga	14	1	0	5			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:56774141T>C	uc002iwu.2	+	3	534	c.492T>C	c.(490-492)TTT>TTC	p.F164F	RAD51C_uc010woa.1_Silent_p.F164F|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	164					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGGAAGTTTTATGGTTGATA	0.423								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.00361	0	95	83										C	56774141	T	C	56774141	2	2	43	1	0	0	0	0	0	0	0	1	12988	1751	61	5		5	RAD51C	17	56774141	Silent	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	1788263	56774141	24421069	225	11332										
OTOP3	347741	broad.mit.edu	37	chr17	72942918	72942918	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccgccacgtggcaccccacaTgggtgcccaccctgccaccg	10	21	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:72942918T>C	uc010wrr.1	+	6	968	c.968T>C	c.(967-969)ATG>ACG	p.M323T	OTOP3_uc010wrq.1_Missense_Mutation_p.M305T	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	323						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					GCACCCCACATGGGTGCCCAC	0.632													0	0	0	0.00361	0	80	180										C	72942918	T	C	72942918	3	2	43	1	0	0	0	0	1	0	0	0	11307	1464	51	5	990	5	OTOP3	17	72942918	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	16168777	72942918	8252292	226	11333										
TNRC6C	57690	broad.mit.edu	37	chr17	76079209	76079209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cctcgccaattaatcctcaaCatatgacgatgttgaaccag	6	12	1	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:76079209C>T	uc002jud.2	+	12	4039	c.3439C>T	c.(3439-3441)CAT>TAT	p.H1147Y	TNRC6C_uc002juf.2_Missense_Mutation_p.H1144Y	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1147					gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TAATCCTCAACATATGACGAT	0.463													0	0	0	0.00361	0	49	42										T	76079209	C	T	76079209	3	4	43	1	0	0	0	0	1	0	0	0	16339	478	17	2	3473	2	TNRC6C	17	76079209	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	3136291	76079209	5116001	227	11334										
ACTG1	71	broad.mit.edu	37	chr17	79478446	79478446	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	cctcgctcagtgaggatcttCatgaggtagtcggtcaggtc	13	10	4	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr17:79478446C>T	uc002kaj.1	-	3	595	c.570G>A	c.(568-570)ATG>ATA	p.M190I	ACTG1_uc002kah.1_Missense_Mutation_p.M68I|ACTG1_uc002kai.1_Missense_Mutation_p.M147I|ACTG1_uc002kak.1_Missense_Mutation_p.M190I|ACTG1_uc010wun.1_Missense_Mutation_p.M190I|ACTG1_uc002kal.1_Missense_Mutation_p.M190I|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	190					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			TGAGGATCTTCATGAGGTAGT	0.642													0	0	0	0.005443	0	26	59										T	79478446	C	T	79478446	3	4	43	1	0	0	0	0	1	0	0	0	196	826	29	1	569	1	ACTG1	17	79478446	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	3399237	79478446	1716764	228	11335										
IMPA2	3613	broad.mit.edu	37	chr18	11999053	11999053	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atcccgtacttttatttcagAtcatcagaaaagcccttact	4	11	3	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr18:11999053A>G	uc002kqp.1	+	2	311	c.97A>G	c.(97-99)ATC>GTC	p.I33V	IMPA2_uc002kqo.1_5'UTR|IMPA2_uc010dlb.1_5'UTR|IMPA2_uc002kqq.1_5'UTR	NM_014214	NP_055029	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	33					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(2)	2					Lithium(DB01356)	TTTATTTCAGATCATCAGAAA	0.423													0	0	0	0.00361	0	56	17										G	11999053	A	G	11999053	3	3	43	1	0	0	0	0	1	0	0	0	7723	347	12	5	103	5	IMPA2	18	11999053	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08		11999053	66078195	229	11336										
ZNF521	25925	broad.mit.edu	37	chr18	22806433	22806433	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttgaggtcgttgacaacttcGgaacagaagttacactggta	11	7	0	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr18:22806433G>A	uc002kvk.2	-	4	1696	c.1449C>T	c.(1447-1449)TCC>TCT	p.S483S	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.S483S|ZNF521_uc002kvl.2_Silent_p.S263S	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	483	C2H2-type 11.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGACAACTTCGGAACAGAAGT	0.443			T	PAX5	ALL								0	0	0	0.006999	0	37	64										A	22806433	G	A	22806433	2	1	43	1	0	0	0	0	0	0	0	1	17962	1103	39	2		2	ZNF521	18	22806433	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	10807380	22806433	55270815	230	11337										
ASXL3	80816	broad.mit.edu	37	chr18	31318937	31318937	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gttaagatagaagggaagtcAgaatcaccccaggaagaaat	11	6	2	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr18:31318937A>G	uc010dmg.1	+	11	1624	c.1569A>G	c.(1567-1569)TCA>TCG	p.S523S	ASXL3_uc002kxq.2_Silent_p.S230S	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	523					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AAGGGAAGTCAGAATCACCCC	0.393													0	0	0	0.008291	0	11	10										G	31318937	A	G	31318937	2	3	43	1	0	0	0	0	0	0	0	1	1068	175	7	5		5	ASXL3	18	31318937	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	8512504	31318937	46758311	231	11338										
WDR88	126248	broad.mit.edu	37	chr19	33663289	33663289	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctgtggaatattgaagaaatTgatgaaattcctttggtaat	9	3	0	4			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:33663289T>C	uc002nui.2	+	10	1263	c.1185T>C	c.(1183-1185)ATT>ATC	p.I395I		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	395	WD 7.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)					TTGAAGAAATTGATGAAATTC	0.323													0	0	0	0.00361	0	74	35										C	33663289	T	C	33663289	2	2	43	1	0	0	0	0	0	0	0	1	17332	1800	63	5		5	WDR88	19	33663289	Silent	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08		33663289	25465694	232	11339										
ZNF829	374899	broad.mit.edu	37	chr19	37383113	37383113	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	agtaacgagtgagccacgacTaaaggacttcccatactcct	8	12	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:37383113T>G	uc002ofa.1	-	6	942	c.580A>C	c.(580-582)AGT>CGT	p.S194R	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	194	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAGCCACGACTAAAGGACTTC	0.368													0	0	0	0.00333	0	24	105										G	37383113	T	G	37383113	3	3	43	1	0	0	0	0	1	0	0	0	18179	1522	53	5	722	5	ZNF829	19	37383113	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	3719824	37383113	21745870	233	11340										
PAF1	54623	broad.mit.edu	37	chr19	39877398	39877398	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	caagcagggcgttggtgcctGactgaaccccagccttggcc	13	14	0	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:39877398G>A	uc002old.2	-	12	1203	c.1028C>T	c.(1027-1029)TCA>TTA	p.S343L	PAF1_uc002ole.1_Missense_Mutation_p.S333L|PAF1_uc010xuv.1_RNA	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	343					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GTTGGTGCCTGACTGAACCCC	0.567													0	0	0	0.00361	0	60	230										A	39877398	G	A	39877398	3	1	43	1	0	0	0	0	1	0	0	0	11383	1294	45	1	579	1	PAF1	19	39877398	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2494285	39877398	19251585	234	11341										
ERCC2	2068	broad.mit.edu	37	chr19	45867687	45867687	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tggcgcccccctcaccaatgTtgtgggcctcgtcgaagacc	11	16	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	WGS			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:45867687T>C	uc002pbj.2	-	8	760	c.713A>G	c.(712-714)AAC>AGC	p.N238S	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.N160S|ERCC2_uc002pbk.2_Missense_Mutation_p.N214S|ERCC2_uc002pbl.3_Missense_Mutation_p.N214S|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	238	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CTCACCAATGTTGTGGGCCTC	0.637			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001855	0	11	6										C	45867687	T	C	45867687	3	2	43	1	0	0	0	0	1	0	0	0	5213	1725	60	5	1690	5	ERCC2	19	45867687	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	5990289	45867687	13261296	235	11342										
PIH1D1	55011	broad.mit.edu	37	chr19	49950297	49950297	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcaccagtttggggaggtcaActtcggccaagaggaggtcg	15	9	2	1	rs17844886		TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:49950297A>G	uc002pns.2	-	7	955	c.671T>C	c.(670-672)GTT>GCT	p.V224A	uc002pnr.1_5'Flank	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17	224					box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		GGGGAGGTCAACTTCGGCCAA	0.592													0	0	0	0.00361	0	102	47										G	49950297	A	G	49950297	3	3	43	1	0	0	0	0	1	0	0	0	11906	43	2	5	213	5	PIH1D1	19	49950297	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	4082610	49950297	9178686	236	11343										
ZSCAN5A	79149	broad.mit.edu	37	chr19	56733066	56733066	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggagtggatgcgctggtgctCcttcaggctccccctgtagg	15	12	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:56733066C>A	uc002qmq.2	-	5	1535	c.1369G>T	c.(1369-1371)GAG>TAG	p.E457*	ZSCAN5A_uc010ygi.1_Nonsense_Mutation_p.E340*|ZSCAN5A_uc002qmr.2_Nonsense_Mutation_p.E457*|ZSCAN5A_uc002qms.1_Nonsense_Mutation_p.E456*	NM_024303	NP_077279	Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	457	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CGCTGGTGCTCCTTCAGGCTC	0.498													1	0	1.50039e-11	0.012319	1.64154e-11	22	90										A	56733066	C	A	56733066	4	1	43	1	0	0	0	0	0	1	0	0	18235	864	30	3	125	3	ZSCAN5A	19	56733066	Nonsense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	6782769	56733066	2395917	237	11344										
ZNF324	25799	broad.mit.edu	37	chr19	58982236	58982236	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aaaaagcctgcagagacaacGgggtgcctccccatctcggg	12	13	1	1	rs145109076	byFrequency	TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr19:58982236G>C	uc002qsw.1	+	4	471	c.377G>C	c.(376-378)CGG>CCG	p.R126P	ZNF324_uc002qsx.1_5'Flank	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CAGAGACAACGGGGTGCCTCC	0.607													0	0	0	0.003954	0	17	112										C	58982236	G	C	58982236	3	2	43	1	0	0	0	0	1	0	0	0	17841	1116	39	4	387	4	ZNF324	19	58982236	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	2249170	58982236	146747	238	11345										
TGM3	7053	broad.mit.edu	37	chr20	2315885	2315885	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgaggtggtggtggagcgggAcatcatcctggacaacccca	15	10	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr20:2315885A>T	uc002wfx.3	+	11	1863	c.1766A>T	c.(1765-1767)GAC>GTC	p.D589V		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	589					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	GTGGAGCGGGACATCATCCTG	0.602													0	0	0	0.004482	0	8	64										T	2315885	A	T	2315885	3	4	43	1	0	0	0	0	1	0	0	0	15828	275	10	5	1808	5	TGM3	20	2315885	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08		2315885	60709635	239	11346										
ZNFX1	57169	broad.mit.edu	37	chr20	47888256	47888256	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gggttattggcctgatttctAgctcttggtggtaactctcc	11	9	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr20:47888256A>G	uc002xui.2	-	3	340	c.93T>C	c.(91-93)GCT>GCC	p.A31A		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	31							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCTGATTTCTAGCTCTTGGTG	0.507													0	0	0	0.008361	0	29	37										G	47888256	A	G	47888256	2	3	43	1	0	0	0	0	0	0	0	1	18202	407	15	5		5	ZNFX1	20	47888256	Silent	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08	45572371	47888256	15137264	240	11347										
ZNF217	7764	broad.mit.edu	37	chr20	52192283	52192283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	taccttctaacgtcgagctgGatgctggactaccagcaggc	11	12	1	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr20:52192283G>A	uc002xwq.3	-	3	3291	c.3020C>T	c.(3019-3021)TCC>TTC	p.S1007F	ZNF217_uc010gij.1_Missense_Mutation_p.S999F	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	1007					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CGTCGAGCTGGATGCTGGACT	0.448													0	0	0	0.003163	0	16	36										A	52192283	G	A	52192283	3	1	43	1	0	0	0	0	1	0	0	0	17769	1174	41	1	134	1	ZNF217	20	52192283	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	4304027	52192283	10833237	241	11348										
PPP1R3D	5509	broad.mit.edu	37	chr20	58514308	58514308	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ctccgtgccctcggggcctgCgggcccgcgccaccgcgcca	14	21	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr20:58514308C>T	uc002ybb.2	-	1	1045	c.679G>A	c.(679-681)GCA>ACA	p.A227T	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	227	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			TCGGGGCCTGCGGGCCCGCGC	0.692													0	0	0	0.003163	0	12	34										T	58514308	C	T	58514308	3	4	43	1	0	0	0	0	1	0	0	0	12374	768	27	2	224	2	PPP1R3D	20	58514308	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	6322025	58514308	4511212	242	11349										
ADRM1	11047	broad.mit.edu	37	chr20	60883123	60883123	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gagataatggctcccatcctCgccaacgcggatgtccagga	11	13	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr20:60883123C>T	uc002ycn.2	+	8	983	c.903C>T	c.(901-903)CTC>CTT	p.L301L	ADRM1_uc002yco.2_Silent_p.L301L	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	301					proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			CTCCCATCCTCGCCAACGCGG	0.627													0	0	0	0.004482	0	9	11										T	60883123	C	T	60883123	2	4	43	1	0	0	0	0	0	0	0	1	345	871	31	1		1	ADRM1	20	60883123	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	2368815	60883123	2142397	243	11350										
C20orf20	55257	broad.mit.edu	37	chr20	61428545	61428545	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	aggtcccatccaaggtcatcTgggaccatctgagcaccatg	10	13	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr20:61428545T>G	uc002ydi.2	+	2	303	c.232T>G	c.(232-234)TGG>GGG	p.W78G		NM_018270	NP_060740	Q9NV56	MRGBP_HUMAN	MRG-binding protein	78					chromatin modification|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	H4/H2A histone acetyltransferase complex					0	Breast(26;3.65e-08)					CAAGGTCATCTGGGACCATCT	0.622													0	0	0	0.008291	0	9	46										G	61428545	T	G	61428545	3	3	43	1	0	0	0	0	1	0	0	0	2103	1580	55	5	238	5	C20orf20	20	61428545	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	545422	61428545	1596975	244	11351										
CRYZL1	9946	broad.mit.edu	37	chr21	34994369	34994369	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tttttcatcttcatttctgcCagaagctaaatcatgacaaa	4	9	5	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr21:34994369C>T	uc011adw.1	-	4	330	c.150G>A	c.(148-150)CTG>CTA	p.L50L	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Silent_p.L74L|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA|CRYZL1_uc002ysu.2_Silent_p.L50L	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	50					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						TCATTTCTGCCAGAAGCTAAA	0.338													0	0	0	0.00361	0	50	90										T	34994369	C	T	34994369	2	4	43	1	0	0	0	0	0	0	0	1	3923	581	21	2		2	CRYZL1	21	34994369	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		34994369	13135526	245	11352										
B3GALT5	10317	broad.mit.edu	37	chr21	41032664	41032664	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ggcagacacctcccttcctcGtcctgctggtgacctcatcc	8	18	1	2	rs146778477		TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr21:41032664G>C	uc002yyb.1	+	5	770	c.178G>C	c.(178-180)GTC>CTC	p.V60L	B3GALT5_uc002yye.2_Missense_Mutation_p.V60L|B3GALT5_uc002yyi.1_Missense_Mutation_p.V60L|B3GALT5_uc002yyj.1_Missense_Mutation_p.V60L|B3GALT5_uc002yyk.1_Missense_Mutation_p.V60L|B3GALT5_uc002yyl.1_Missense_Mutation_p.V60L|B3GALT5_uc002yym.1_Missense_Mutation_p.V60L	NM_033173	NP_149363	Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta	60	Lumenal (Potential).				protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1		Prostate(19;2.55e-06)				TCCCTTCCTCGTCCTGCTGGT	0.522													0	0	0	0.010729	0	12	113										C	41032664	G	C	41032664	3	2	43	1	0	0	0	0	1	0	0	0	1250	1145	40	4	180	4	B3GALT5	21	41032664	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	6038295	41032664	7097231	246	11353										
ARVCF	421	broad.mit.edu	37	chr22	19961220	19961220	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gttgcgcagagcgatggcgaCggcgcgcaccaccttgtcgg	16	13	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr22:19961220C>T	uc002zqz.2	-	13	2456	c.2185G>A	c.(2185-2187)GTC>ATC	p.V729I	ARVCF_uc002zqy.2_Missense_Mutation_p.V245I	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	729	ARM 8.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					GCGATGGCGACGGCGCGCACC	0.662													0	0	0	0.010504	0	20	150										T	19961220	C	T	19961220	3	4	43	1	0	0	0	0	1	0	0	0	1003	536	19	2	731	2	ARVCF	22	19961220	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08		19961220	31343346	247	11354										
MYH9	4627	broad.mit.edu	37	chr22	36697582	36697582	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gcctgcactgacacccacctGagactgcagcgtctccatct	8	17	2	2			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr22:36697582G>A	uc003apg.2	-	21	2860	c.2629C>T	c.(2629-2631)CAG>TAG	p.Q877*	MYH9_uc003aph.1_Nonsense_Mutation_p.Q741*	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	877	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						ACACCCACCTGAGACTGCAGC	0.607			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated		OREG0026520	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	22	56										A	36697582	G	A	36697582	4	1	43	1	0	0	0	0	0	1	0	0	10042	1299	45	1	3337	1	MYH9	22	36697582	Nonsense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	16736362	36697582	14606984	248	11355										
EP300	2033	broad.mit.edu	37	chr22	41553195	41553195	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ttactttgatattgtgaagaGccccatggatctttctacca	7	9	2	3			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	WGS			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr22:41553195G>T	uc003azl.3	+	18	3679	c.3284G>T	c.(3283-3285)AGC>ATC	p.S1095I		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1095	Bromo.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATTGTGAAGAGCCCCATGGAT	0.393			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				1	0	2.94398e-08	0.007413	3.17667e-08	19	29										T	41553195	G	T	41553195	3	4	43	1	0	0	0	0	1	0	0	0	5148	971	34	4	3354	4	EP300	22	41553195	Missense_Mutation	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	4855613	41553195	9751371	249	11356										
POLR3H	171568	broad.mit.edu	37	chr22	41928097	41928097	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	actttaacccttggaggataCaacttggctggctgctgcag	11	10	0	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr22:41928097C>A	uc003baf.2	-	5	419	c.359_splice	c.e5+1	p.F120_splice	POLR3H_uc003bae.2_Splice_Site|POLR3H_uc003bag.2_Splice_Site_p.F120_splice|POLR3H_uc003bai.2_Splice_Site_p.F91_splice	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide						innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						TTGGAGGATACAACTTGGCTG	0.557													1	0	1.04121e-07	0.005443	1.11584e-07	22	28										A	41928097	C	A	41928097	5	1	43	1	0	0	0	0	0	0	1	0	12236	492	17	4	266	4	POLR3H	22	41928097	Splice_Site	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	374902	41928097	9376469	250	11357										
PMM1	5372	broad.mit.edu	37	chr22	41980552	41980552	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgcttggagagcagtcgtccGtgcttatactgcaccgtccc	11	13	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr22:41980552G>A	uc003bal.2	-	3	323	c.261C>T	c.(259-261)CAC>CAT	p.H87H		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	87					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						GCAGTCGTCCGTGCTTATACT	0.552													0	0	0	0.00361	0	51	36										A	41980552	G	A	41980552	2	1	43	1	0	0	0	0	0	0	0	1	12136	1136	40	2		2	PMM1	22	41980552	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	52455	41980552	9324014	251	11358										
MOV10L1	54456	broad.mit.edu	37	chr22	50563824	50563824	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	atttgggtgttttccagcttCtgaacatgtcaaattacaag	8	7	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chr22:50563824C>T	uc003bjj.2	+	11	1656	c.1573C>T	c.(1573-1575)CTG>TTG	p.L525L	MOV10L1_uc003bjk.3_Silent_p.L525L|MOV10L1_uc011arp.1_Silent_p.L505L|MOV10L1_uc011arq.1_Silent_p.L286L|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	525					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TTTCCAGCTTCTGAACATGTC	0.438													0	0	0	0.004878	0	34	11										T	50563824	C	T	50563824	2	4	43	1	0	0	0	0	0	0	0	1	9719	912	32	1		1	MOV10L1	22	50563824	Silent	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	8583272	50563824	740742	252	11359										
MSL3	10943	broad.mit.edu	37	chrX	11783848	11783848	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tcttcctgcacctggaaaagAgtaggttcattctcgggtgc	11	10	3	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chrX:11783848A>G	uc004cuw.2	+	9	1276	c.1171A>G	c.(1171-1173)AAG>GAG	p.K391E	MSL3_uc004cuv.1_Missense_Mutation_p.S391G|MSL3_uc004cux.2_Missense_Mutation_p.K332E|MSL3_uc011mig.1_Missense_Mutation_p.K242E|MSL3_uc011mih.1_Missense_Mutation_p.K379E|MSL3_uc004cuy.2_Missense_Mutation_p.K225E	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	391					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCTGGAAAAGAGTAGGTTCAT	0.582													0	0	0	0.006999	0	39	39										G	11783848	A	G	11783848	3	3	43	1	0	0	0	0	1	0	0	0	9879	318	11	5	1205	5	MSL3	23	11783848	Missense_Mutation	SNP	A	TCGA-DK-A1A7-01A-11D-A13W-08		11783848	143486712	253	11360										
KDM6A	7403	broad.mit.edu	37	chrX	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	ccagagtgcctagcgtctctCagcctggagtccgtcctgcc	11	16	2	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	WGS			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.006122	0	13	9										T	44922802	C	T	44922802	4	4	43	1	0	0	0	0	0	1	0	0	8137	827	29	1	1725	1	KDM6A	23	44922802	Nonsense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	33138954	44922802	110347758	254	11361										
VSIG4	11326	broad.mit.edu	37	chrX	65242174	65242174	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	actgtgtccagcaggcgggcGtagttgccattgatctgggc	15	10	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chrX:65242174G>A	uc004dwh.2	-	8	1258	c.1131C>T	c.(1129-1131)TAC>TAT	p.Y377Y	VSIG4_uc004dwi.2_Silent_p.Y283Y|VSIG4_uc010nkq.1_3'UTR|VSIG4_uc004dwj.2_3'UTR|VSIG4_uc011moy.1_3'UTR|VSIG4_uc004dwk.2_3'UTR|VSIG4_uc004dwl.2_Intron	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	377	Cytoplasmic (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						GCAGGCGGGCGTAGTTGCCAT	0.517													0	0	0	0.00308	0	7	14										A	65242174	G	A	65242174	2	1	43	1	0	0	0	0	0	0	0	1	17222	1140	40	2		2	VSIG4	23	65242174	Silent	SNP	G	TCGA-DK-A1A7-01A-11D-A13W-08	20319372	65242174	90028386	255	11362										
OGT	8473	broad.mit.edu	37	chrX	70784470	70784470	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	gatcaacaataaggctgcaaCtggagaggaggttccccgta	12	9	1	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chrX:70784470C>T	uc004eaa.1	+	19	2673	c.2456C>T	c.(2455-2457)ACT>ATT	p.T819I	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.T809I|OGT_uc004eac.2_Missense_Mutation_p.T680I|OGT_uc004ead.2_Missense_Mutation_p.T438I	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	819					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					AAGGCTGCAACTGGAGAGGAG	0.368													0	0	0	0.006122	0	15	14										T	70784470	C	T	70784470	3	4	43	1	0	0	0	0	1	0	0	0	10847	565	20	2	2530	2	OGT	23	70784470	Missense_Mutation	SNP	C	TCGA-DK-A1A7-01A-11D-A13W-08	5542296	70784470	84486090	256	11363										
TAF7L	54457	broad.mit.edu	37	chrX	100532627	100532627	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	accctgcttgtggctgctcaTtcccgaggatatcaaaaatc	8	12	2	0			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chrX:100532627T>A	uc004ehb.2	-	9	928	c.916A>T	c.(916-918)ATG>TTG	p.M306L	TAF7L_uc004eha.2_Missense_Mutation_p.M220L|TAF7L_uc004ehc.1_Missense_Mutation_p.M220L	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	306					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						TGGCTGCTCATTCCCGAGGAT	0.458													0	0	0	0.00361	0	69	38										A	100532627	T	A	100532627	3	1	43	1	0	0	0	0	1	0	0	0	15530	1493	52	5	492	5	TAF7L	23	100532627	Missense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	29748157	100532627	54737933	257	11364										
GPR112	139378	broad.mit.edu	37	chrX	135428141	135428141	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.127906976744186	33	0.00225405336053257	1.68273160087284	1.33383988139362	1.81021126760563	2.54461633860286e-05	0.000183777846676873	13	tgaatttaaacttaccacttTactactaaaaacaataccta	1	9	0	1			TCGA-DK-A1A7-01A-11D-A13W-08	TCGA-DK-A1A7-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	91f458e6-64b7-454d-a542-b0aa23638fd8	c14e29aa-a979-4452-8019-7eebfb3d5d04	g.chrX:135428141T>G	uc004ezu.1	+	6	2567	c.2276T>G	c.(2275-2277)TTA>TGA	p.L759*	GPR112_uc010nsb.1_Nonsense_Mutation_p.L554*|GPR112_uc010nsc.1_Nonsense_Mutation_p.L526*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	759	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTTACCACTTTACTACTAAAA	0.358													0	0	0	0.00333	0	23	25										G	135428141	T	G	135428141	4	3	43	1	0	0	0	0	0	1	0	0	6629	1764	61	5	2286	5	GPR112	23	135428141	Nonsense_Mutation	SNP	T	TCGA-DK-A1A7-01A-11D-A13W-08	34895514	135428141	19842419	258	11365										
MYSM1	114803	broad.mit.edu	37	chr1	59156029	59156029	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tacctcttcatgtattttttAtcatcttccttttgatcaag	3	9	5	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:59156029A>T	uc009wab.1	-	4	302	c.279T>A	c.(277-279)GAT>GAA	p.D93E	MYSM1_uc001czc.2_RNA|MYSM1_uc001czd.2_Missense_Mutation_p.D93E	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	93					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TGTATTTTTTATCATCTTCCT	0.274													0	0	0	0.004878	0	36	36										T	59156029	A	T	59156029	3	4	44	1	0	0	0	0	1	0	0	0	10101	446	16	5	2275	5	MYSM1	1	59156029	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08		59156029	190094592	1	11366										
RBM15	64783	broad.mit.edu	37	chr1	110882341	110882341	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ccacctggacaagtccagcaGtcgaggtggcagccgcgagt	14	13	0	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:110882341G>A	uc001dzl.1	+	1	397	c.314G>A	c.(313-315)AGT>AAT	p.S105N	RBM15_uc001dzm.1_Missense_Mutation_p.S105N|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	105	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AAGTCCAGCAGTCGAGGTGGC	0.622			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	16										A	110882341	G	A	110882341	3	1	44	1	0	0	0	0	1	0	0	0	13116	1029	36	2	316	2	RBM15	1	110882341	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	51726312	110882341	138368280	2	11367										
WDR3	10885	broad.mit.edu	37	chr1	118476014	118476014	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gttatcggcagccaaaaaggTaatattgtctttgtgacact	9	7	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:118476014T>G	uc010oxe.1	+	2	138	c.72T>G	c.(70-72)GGT>GGG	p.G24G	WDR3_uc001ehi.2_Splice_Site|WDR3_uc001ehh.2_Splice_Site	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	24	WD 1.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GCCAAAAAGGTAATATTGTCT	0.478													0	0	0	0.00245	0	8	47										G	118476014	T	G	118476014	2	3	44	1	0	0	0	0	0	0	0	1	17282	1625	57	5		5	WDR3	1	118476014	Silent	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08	7593673	118476014	130774607	3	11368										
BCL9	607	broad.mit.edu	37	chr1	147092477	147092477	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cacagctcctccagttcagcGcggcctggggcggaagccct	13	16	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:147092477G>T	uc001epq.2	+	8	3256	c.2516G>T	c.(2515-2517)CGC>CTC	p.R839L	BCL9_uc010ozr.1_Missense_Mutation_p.R765L	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	839	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CCAGTTCAGCGCGGCCTGGGG	0.592			T	IGH@|IGL@	B-ALL								1	0	2.47316e-13	0.003271	2.75032e-13	27	54										T	147092477	G	T	147092477	3	4	44	1	0	0	0	0	1	0	0	0	1381	1087	38	4	2534	4	BCL9	1	147092477	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	28616463	147092477	102158144	4	11369										
LCE3D	84648	broad.mit.edu	37	chr1	152552220	152552220	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	acaggagttgggcctctggcGccggcatcggtggtggcgcc	18	12	1	0	rs147417899	byFrequency	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:152552220G>A	uc001fab.2	-	2	250	c.193C>T	c.(193-195)CGC>TGC	p.R65C		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	65					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGCCTCTGGCGCCGGCATCGG	0.682													0	0	0	0.013114	0	42	61										A	152552220	G	A	152552220	3	1	44	1	0	0	0	0	1	0	0	0	8672	1087	38	2	89	2	LCE3D	1	152552220	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	5459743	152552220	96698401	5	11370										
NUP210L	91181	broad.mit.edu	37	chr1	153998026	153998026	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ccatgaactcacctggacccCagttatggttgtttggttga	10	10	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:153998026C>A	uc001fdw.2	-	30	4186	c.4114G>T	c.(4114-4116)GGG>TGG	p.G1372W	NUP210L_uc009woq.2_Missense_Mutation_p.G281W|NUP210L_uc010peh.1_Missense_Mutation_p.G1372W	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1372						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ACCTGGACCCCAGTTATGGTT	0.383													1	0	3.86212e-05	0.008291	4.08372e-05	10	244										A	153998026	C	A	153998026	3	1	44	1	0	0	0	0	1	0	0	0	10761	594	21	4	1596	4	NUP210L	1	153998026	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	1445806	153998026	95252595	6	11371										
KIRREL	55243	broad.mit.edu	37	chr1	158064739	158064739	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttccctggggcagctgggtaCcccacctaccgactgggcta	12	15	0	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:158064739C>T	uc001frn.3	+	15	2507	c.2103C>T	c.(2101-2103)TAC>TAT	p.Y701Y	KIRREL_uc010pib.1_Silent_p.Y601Y|KIRREL_uc009wsq.2_Silent_p.Y537Y|KIRREL_uc001fro.3_Silent_p.Y515Y|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	701	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CAGCTGGGTACCCCACCTACC	0.632													0	0	0	0.006122	0	16	28										T	158064739	C	T	158064739	2	4	44	1	0	0	0	0	0	0	0	1	8324	518	18	2		2	KIRREL	1	158064739	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	4066713	158064739	91185882	7	11372										
SLC9A11	284525	broad.mit.edu	37	chr1	173499145	173499145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	actatacatcaagctgaggcGctttttgatctgcacatctg	8	10	3	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:173499145G>A	uc001giz.2	-	18	2635	c.2212C>T	c.(2212-2214)CGC>TGC	p.R738C	SLC9A11_uc009wwe.2_Missense_Mutation_p.R296C|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	738					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						AAGCTGAGGCGCTTTTTGATC	0.323													0	0	0	0.008361	0	30	23										A	173499145	G	A	173499145	3	1	44	1	0	0	0	0	1	0	0	0	14711	1087	38	2	1206	2	SLC9A11	1	173499145	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	15434406	173499145	75751476	8	11373										
LAD1	3898	broad.mit.edu	37	chr1	201355634	201355635	+	Frame_Shift_Ins	INS	-	-	G													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ccaggggctgctctgaggctINSgtggccctctttggggccgg					rs140126456	by1000genomes	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:201355634_201355635insG	uc001gwm.2	-	3	1089_1090	c.854_855insC	c.(853-855)ACAfs	p.T285fs	LAD1_uc009wzu.1_Frame_Shift_Ins_p.T307fs	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	285						basement membrane	structural molecule activity				0						GCTCTGAGGCTGTGGCCCTCTT	0.634																		8	193	---	---								G	201355635	-	G	201355634	7	5	44	1	0	1	1	0	0	0	0	0	8599	1567	55	0	730	0	LAD1	1	201355634	Frame_Shift_Ins	INS	-	TCGA-DK-A1AA-01A-11D-A13W-08	27856489	201355634	47894987	9	11374										
RYR2	6262	broad.mit.edu	37	chr1	237947439	237947439	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tcgaaatcatgggaagcgccAaacgcatcgagagggtctat	12	9	2	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:237947439A>G	uc001hyl.1	+	90	12547	c.12427A>G	c.(12427-12429)AAA>GAA	p.K4143E	RYR2_uc010pya.1_Missense_Mutation_p.K558E	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4143					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGGAAGCGCCAAACGCATCGA	0.502													0	0	0	0.006122	0	18	24										G	237947439	A	G	237947439	3	3	44	1	0	0	0	0	1	0	0	0	13769	131	5	5	12785	5	RYR2	1	237947439	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	36591805	237947439	11303182	10	11375										
TPO	7173	broad.mit.edu	37	chr2	1500391	1500391	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	caagtgtggcttcccagagaGcgtggagaatggggactttg	16	7	0	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:1500391G>A	uc002qww.2	+	13	2331	c.2240G>A	c.(2239-2241)AGC>AAC	p.S747N	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.S690N|TPO_uc002qwr.2_Missense_Mutation_p.S747N|TPO_uc002qwx.2_Missense_Mutation_p.S690N|TPO_uc010yio.1_Missense_Mutation_p.S574N|TPO_uc010yip.1_Missense_Mutation_p.S747N|TPO_uc002qwy.1_Missense_Mutation_p.S87N|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	747	Extracellular (Potential).|Sushi.				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TTCCCAGAGAGCGTGGAGAAT	0.557													0	0	0	0.001168	0	6	102										A	1500391	G	A	1500391	3	1	44	1	0	0	0	0	1	0	0	0	16407	971	34	2	2286	2	TPO	2	1500391	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		1500391	241698982	11	11376										
ATAD2B	54454	broad.mit.edu	37	chr2	23980429	23980429	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttctggtttttcttttgactGgtcctccagaagaatctttt	7	8	3	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:23980429G>C	uc002rek.3	-	25	4231	c.3937C>G	c.(3937-3939)CAG>GAG	p.Q1313E	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.Q553E|ATAD2B_uc002rej.3_Missense_Mutation_p.Q481E	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1313							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTTTGACTGGTCCTCCAGA	0.383													0	0	0	0.00333	0	25	34										C	23980429	G	C	23980429	3	2	44	1	0	0	0	0	1	0	0	0	1072	1357	47	4	455	4	ATAD2B	2	23980429	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	22480038	23980429	219218944	12	11377										
PLEK	5341	broad.mit.edu	37	chr2	68607901	68607901	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	acagcaggaccacttcttccAggcagccttcctggaggaga	11	13	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:68607901A>G	uc002sen.3	+	3	407	c.245A>G	c.(244-246)CAG>CGG	p.Q82R	PLEK_uc010fde.2_Missense_Mutation_p.Q82R	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	82	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CACTTCTTCCAGGCAGCCTTC	0.468													0	0	0	0.011902	0	41	58										G	68607901	A	G	68607901	3	3	44	1	0	0	0	0	1	0	0	0	12053	188	7	5	255	5	PLEK	2	68607901	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	44627472	68607901	174591472	13	11378										
GKN1	56287	broad.mit.edu	37	chr2	69201773	69201774	+	Frame_Shift_Ins	INS	-	-	G													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tctcattcaggtccatgcttINSgcctactcctctgtccactg							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:69201773_69201774insG	uc002sfc.2	+	1	69_70	c.6_7insG	c.(4-9)CTTGCCfs	p.L2fs		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	2_3					digestion|positive regulation of cell division	extracellular region				breast(1)	1						GGTCCATGCTTGCCTACTCCTC	0.411																		33	37	---	---								G	69201774	-	G	69201773	7	5	44	1	0	1	1	0	0	0	0	0	6424	1799	63	0	8	0	GKN1	2	69201773	Frame_Shift_Ins	INS	-	TCGA-DK-A1AA-01A-11D-A13W-08	593872	69201773	173997600	14	11379										
FBLN7	129804	broad.mit.edu	37	chr2	112944789	112944789	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	accatctccttccattacctCtctctgccttccaacctgaa	2	18	3	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:112944789C>A	uc002tho.1	+	8	1297	c.1026C>A	c.(1024-1026)CTC>CTA	p.L342L	FBLN7_uc002thn.2_Intron|FBLN7_uc010fki.1_Silent_p.L296L|FBLN7_uc010fkj.1_Silent_p.L208L	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	342					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						TCCATTACCTCTCTCTGCCTT	0.642													1	0	7.05377e-20	0.01441	8.27215e-20	48	71										A	112944789	C	A	112944789	2	1	44	1	0	0	0	0	0	0	0	1	5701	900	32	3		3	FBLN7	2	112944789	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	43743016	112944789	130254584	15	11380										
TTN	7273	broad.mit.edu	37	chr2	179410748	179410748	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cacgatgtagtgagtgatttCtgctcctccgtcttcctgcg	10	12	2	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:179410748C>T	uc010zfg.1	-	292	87735	c.87511G>A	c.(87511-87513)GAA>AAA	p.E29171K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22866K|TTN_uc010zfi.1_Missense_Mutation_p.E22799K|TTN_uc010zfj.1_Missense_Mutation_p.E22674K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30098							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGTGATTTCTGCTCCTCCG	0.532													0	0	0	0.008871	0	18	16										T	179410748	C	T	179410748	3	4	44	1	0	0	0	0	1	0	0	0	16732	922	32	1	12844	1	TTN	2	179410748	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	66465959	179410748	63788625	16	11381										
TTN	7273	broad.mit.edu	37	chr2	179612398	179612398	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cctcacgctttccagcagcaAgtaaatattgtgttagggag	10	9	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:179612398A>G	uc002unb.2	-	46	14953	c.14729T>C	c.(14728-14730)CTT>CCT	p.L4910P	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGCAGCAAGTAAATATTG	0.413													0	0	0	0.006214	0	9	22										G	179612398	A	G	179612398	3	3	44	1	0	0	0	0	1	0	0	0	16732	72	3	5	95568	5	TTN	2	179612398	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	201650	179612398	63586975	17	11382										
TTN	7273	broad.mit.edu	37	chr2	179656911	179656911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttggtacaaatgttttttcaGtttcttttcttatctgcaaa	5	6	4	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:179656911G>A	uc010zfg.1	-	10	1774	c.1550C>T	c.(1549-1551)ACT>ATT	p.T517I	TTN_uc010zfh.1_Missense_Mutation_p.T517I|TTN_uc010zfi.1_Missense_Mutation_p.T517I|TTN_uc010zfj.1_Missense_Mutation_p.T517I|TTN_uc002unb.2_Missense_Mutation_p.T517I|TTN_uc010frg.1_Missense_Mutation_p.T191I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	517							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTTTTCAGTTTCTTTTCT	0.279													0	0	0	0.006122	0	17	23										A	179656911	G	A	179656911	3	1	44	1	0	0	0	0	1	0	0	0	16732	1029	36	2	109850	2	TTN	2	179656911	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	44513	179656911	63542462	18	11383										
C2orf67	151050	broad.mit.edu	37	chr2	210962866	210962866	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	caggatttggaagagaggggTgatgaagttggggacaagtt	18	2	0	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:210962866T>G	uc002vds.2	-	5	1702	c.1494A>C	c.(1492-1494)TCA>TCC	p.S498S	C2orf67_uc002vdt.2_Silent_p.S498S|C2orf67_uc002vdw.2_Silent_p.S498S|C2orf67_uc002vdv.2_Silent_p.S498S|C2orf67_uc002vdx.1_Silent_p.S498S	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	498										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		AAGAGAGGGGTGATGAAGTTG	0.423													0	0	0	0.004482	0	4	17										G	210962866	T	G	210962866	2	3	44	1	0	0	0	0	0	0	0	1	2186	1683	59	5		5	C2orf67	2	210962866	Silent	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08	31305955	210962866	32236507	19	11384										
LMCD1	29995	broad.mit.edu	37	chr3	8543629	8543629	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cccaccccagaagaggatggCaaaggtggctaaggacctca	12	12	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:8543629C>A	uc003bqq.2	+	1	119	c.5C>A	c.(4-6)GCA>GAA	p.A2E	uc003bqp.2_5'Flank|LMCD1_uc011atd.1_5'UTR|LMCD1_uc011ate.1_5'UTR	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	2					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AAGAGGATGGCAAAGGTGGCT	0.572													1	0	4.4004e-07	0.00333	4.69134e-07	21	50										A	8543629	C	A	8543629	3	1	44	1	0	0	0	0	1	0	0	0	8844	710	25	4	7	4	LMCD1	3	8543629	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08		8543629	189478801	20	11385										
RAD18	56852	broad.mit.edu	37	chr3	8988964	8988964	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ggttatttttcagatccggcTctgtgacagtctagaaaaaa	9	7	3	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:8988964T>C	uc003brd.2	-	4	283	c.206A>G	c.(205-207)GAG>GGG	p.E69G	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	69					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		CAGATCCGGCTCTGTGACAGT	0.343								Rad6_pathway					0	0	0	0.009718	0	44	68										C	8988964	T	C	8988964	3	2	44	1	0	0	0	0	1	0	0	0	12980	1551	54	5	1321	5	RAD18	3	8988964	Missense_Mutation	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08	445335	8988964	189033466	21	11386										
EXOG	9941	broad.mit.edu	37	chr3	38565704	38565704	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	caagaaagattgaaggagccCgatcagtgctcagactggaa	12	8	2	4			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:38565704C>T	uc003cih.2	+	6	1054	c.958C>T	c.(958-960)CGA>TGA	p.R320*	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Nonsense_Mutation_p.R270*|EXOG_uc003cij.2_Nonsense_Mutation_p.R180*|EXOG_uc010hhd.2_Nonsense_Mutation_p.R180*|EXOG_uc010hhe.2_Nonsense_Mutation_p.R180*|EXOG_uc003cik.2_Nonsense_Mutation_p.R180*|EXOG_uc010hhf.2_Nonsense_Mutation_p.R180*|EXOG_uc003cii.2_Nonsense_Mutation_p.R180*	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	320						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						TGAAGGAGCCCGATCAGTGCT	0.423													0	0	0	0.01441	0	62	115										T	38565704	C	T	38565704	4	4	44	1	0	0	0	0	0	1	0	0	5312	644	23	2	980	2	EXOG	3	38565704	Nonsense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	29576740	38565704	159456726	22	11387										
SCN5A	6331	broad.mit.edu	37	chr3	38639411	38639411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ccagatcaggtagcgctgggCgagacggttccagcatggtg	16	10	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:38639411C>T	uc003cio.2	-	14	2265	c.2071G>A	c.(2071-2073)GCC>ACC	p.A691T	SCN5A_uc003cin.2_Missense_Mutation_p.A691T|SCN5A_uc003cil.3_Missense_Mutation_p.A691T|SCN5A_uc010hhi.2_Missense_Mutation_p.A691T|SCN5A_uc010hhk.2_Missense_Mutation_p.A691T|SCN5A_uc011ayr.1_Missense_Mutation_p.A691T|SCN5A_uc010hhj.1_Missense_Mutation_p.A302T	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	691					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TAGCGCTGGGCGAGACGGTTC	0.532													0	0	0	0.00499	0	15	79										T	38639411	C	T	38639411	3	4	44	1	0	0	0	0	1	0	0	0	13922	768	27	2	4039	2	SCN5A	3	38639411	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	73707	38639411	159383019	23	11388										
CACNA1D	776	broad.mit.edu	37	chr3	53756393	53756393	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gcagaagatgtagggccgccGtgaagtctgtcacgttttac	13	9	2	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:53756393G>T	uc003dgv.3	+	12	1721	c.1558G>T	c.(1558-1560)GTG>TTG	p.V520L	CACNA1D_uc003dgu.3_Missense_Mutation_p.V540L|CACNA1D_uc003dgy.3_Missense_Mutation_p.V520L|CACNA1D_uc003dgw.3_Missense_Mutation_p.V187L	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	520	Cytoplasmic (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TAGGGCCGCCGTGAAGTCTGT	0.483													1	0	8.86878e-18	0.01441	1.01245e-17	44	31										T	53756393	G	T	53756393	3	4	44	1	0	0	0	0	1	0	0	0	2541	1145	40	4	1776	4	CACNA1D	3	53756393	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	15116982	53756393	144266037	24	11389										
CACNA1D	776	broad.mit.edu	37	chr3	53837556	53837556	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gggagcaggagtatttcagtAgtgaggaatgctacgaggat	16	4	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:53837556A>G	uc003dgv.3	+	44	5705	c.5542A>G	c.(5542-5544)AGT>GGT	p.S1848G	CACNA1D_uc003dgu.3_Missense_Mutation_p.S1868G|CACNA1D_uc003dgy.3_Missense_Mutation_p.S1824G|CACNA1D_uc003dgw.3_Missense_Mutation_p.S1515G|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1848	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GTATTTCAGTAGTGAGGAATG	0.602													0	0	0	0.01441	0	123	125										G	53837556	A	G	53837556	3	3	44	1	0	0	0	0	1	0	0	0	2541	420	15	5	5888	5	CACNA1D	3	53837556	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	81163	53837556	144184874	25	11390										
CADPS	8618	broad.mit.edu	37	chr3	62739249	62739249	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tcatccgggcctgctgcttcCgcgggtcctcttctccacgg	11	17	3	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:62739249C>T	uc003dll.2	-	3	1115	c.755G>A	c.(754-756)CGG>CAG	p.R252Q	CADPS_uc003dlm.2_Missense_Mutation_p.R252Q|CADPS_uc003dln.2_Missense_Mutation_p.R252Q	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	252					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CTGCTGCTTCCGCGGGTCCTC	0.567													0	0	0	0.007413	0	19	23										T	62739249	C	T	62739249	3	4	44	1	0	0	0	0	1	0	0	0	2570	652	23	2	3491	2	CADPS	3	62739249	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	8901693	62739249	135283181	26	11391										
MORC1	27136	broad.mit.edu	37	chr3	108819338	108819338	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttggatcgtccaaagtaaatGatgtctgaagcttcctctgt	9	8	2	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:108819338G>C	uc003dxl.2	-	5	327	c.240C>G	c.(238-240)ATC>ATG	p.I80M	MORC1_uc011bhn.1_Missense_Mutation_p.I80M	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	80					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CAAAGTAAATGATGTCTGAAG	0.433													0	0	0	0.008361	0	29	50										C	108819338	G	C	108819338	3	2	44	1	0	0	0	0	1	0	0	0	9701	1280	45	1	2810	1	MORC1	3	108819338	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	46080089	108819338	89203092	27	11392										
BCHE	590	broad.mit.edu	37	chr3	165548632	165548632	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tcgaagtctaccaagaggtgGctgtgcatagggaattccaa	12	8	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:165548632G>T	uc003fem.3	-	2	350	c.190C>A	c.(190-192)CCA>ACA	p.P64T	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	64					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CCAAGAGGTGGCTGTGCATAG	0.418													1	0	0.00307968	0.00308	0.00320386	8	9										T	165548632	G	T	165548632	3	4	44	1	0	0	0	0	1	0	0	0	1358	1203	42	4	1630	4	BCHE	3	165548632	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	56729294	165548632	32473798	28	11393										
HRG	3273	broad.mit.edu	37	chr3	186394879	186394879	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	accgcctcatttgggacatcCcttccactggggtgggcatg	12	13	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:186394879C>A	uc003fqq.2	+	7	808	c.785C>A	c.(784-786)CCC>CAC	p.P262H		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	262					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		TTGGGACATCCCTTCCACTGG	0.468													1	0	2.52637e-11	0.005524	2.76188e-11	34	44										A	186394879	C	A	186394879	3	1	44	1	0	0	0	0	1	0	0	0	7354	623	22	4	811	4	HRG	3	186394879	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	20846247	186394879	11627551	29	11394										
C3orf43	255798	broad.mit.edu	37	chr3	196235134	196235134	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctggcagcttctcaagcacaCgagtatgcaagcagataagt	10	10	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:196235134C>T	uc003fws.2	-	3	426	c.269G>A	c.(268-270)CGT>CAT	p.R90H	C3orf43_uc003fwr.2_Missense_Mutation_p.R82H	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	90						integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		CTCAAGCACACGAGTATGCAA	0.423													0	0	0	0.01441	0	88	110										T	196235134	C	T	196235134	3	4	44	1	0	0	0	0	1	0	0	0	2230	536	19	2	379	2	C3orf43	3	196235134	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	9840255	196235134	1787296	30	11395										
FAM53A	152877	broad.mit.edu	37	chr4	1656882	1656882	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctgctgctggcccagggcagGggagtgcccgcacccgcgag	17	15	0	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:1656882G>A	uc011bve.1	-	4	903	c.705C>T	c.(703-705)CCC>CCT	p.P235P	FAM53A_uc010ibw.2_Silent_p.P235P	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	235						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			CCCAGGGCAGGGGAGTGCCCG	0.741													0	0	0	0.013537	0	9	0										A	1656882	G	A	1656882	2	1	44	1	0	0	0	0	0	0	0	1	5579	1219	43	2		2	FAM53A	4	1656882	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		1656882	189497394	31	11396										
PDGFRA	5156	broad.mit.edu	37	chr4	55130019	55130019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttaatgggaccttcactgtaGggccctatatctgtgaggcc	11	10	2	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:55130019G>A	uc003han.3	+	4	884	c.553G>A	c.(553-555)GGG>AGG	p.G185R	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_Missense_Mutation_p.G185R|PDGFRA_uc010igq.1_Missense_Mutation_p.G79R|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	185	Extracellular (Potential).|Ig-like C2-type 2.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTTCACTGTAGGGCCCTATAT	0.478			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.00278	0	24	29										A	55130019	G	A	55130019	3	1	44	1	0	0	0	0	1	0	0	0	11661	1000	35	2	563	2	PDGFRA	4	55130019	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	53473137	55130019	136024257	32	11397										
KIAA1211	57482	broad.mit.edu	37	chr4	57182439	57182439	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gagggactccgctgaaccttCcagcagccgctctgttcctg	11	15	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:57182439C>A	uc003hbk.2	+	8	3162	c.2771C>A	c.(2770-2772)TCC>TAC	p.S924Y	KIAA1211_uc010iha.2_Missense_Mutation_p.S917Y|KIAA1211_uc011bzz.1_Missense_Mutation_p.S834Y|KIAA1211_uc003hbm.1_Missense_Mutation_p.S810Y	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	924										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCTGAACCTTCCAGCAGCCGC	0.647													1	0	1.22574e-08	0.014323	1.32874e-08	23	21										A	57182439	C	A	57182439	3	1	44	1	0	0	0	0	1	0	0	0	8215	855	30	3	2789	3	KIAA1211	4	57182439	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	2052420	57182439	133971837	33	11398										
PRKG2	5593	broad.mit.edu	37	chr4	82126123	82126123	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cagctctgtcaccttgttccGcagagcatcagtggtgaggt	12	11	3	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:82126123G>A	uc003hmh.2	-	1	93	c.79C>T	c.(79-81)CGG>TGG	p.R27W	PRKG2_uc011cch.1_Missense_Mutation_p.R27W	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	27					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ACCTTGTTCCGCAGAGCATCA	0.527													0	0	0	0.010729	0	11	11										A	82126123	G	A	82126123	3	1	44	1	0	0	0	0	1	0	0	0	12523	1086	38	2	2281	2	PRKG2	4	82126123	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	24943684	82126123	109028153	34	11399										
CCNA2	890	broad.mit.edu	37	chr4	122740027	122740027	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ataactgatggcaaatacttGaggtatgggtcagcatctat	10	6	2	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:122740027G>C	uc003iec.3	-	6	1349	c.1044C>G	c.(1042-1044)CTC>CTG	p.L348L		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	348					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						GCAAATACTTGAGGTATGGGT	0.388													0	0	0	0.003954	0	25	31										C	122740027	G	C	122740027	2	2	44	1	0	0	0	0	0	0	0	1	2910	1277	45	1		1	CCNA2	4	122740027	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	40613904	122740027	68414249	35	11400										
GPM6A	2823	broad.mit.edu	37	chr4	176622885	176622885	+	Frame_Shift_Del	DEL	C	C	-													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tcagagaggcatagggaatgCcccccaggcatttgatacag							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:176622885delC	uc003iuf.2	-	2	875	c.71delG	c.(70-72)GGCfs	p.G24fs	GPM6A_uc011ckj.1_Frame_Shift_Del_p.G17fs|GPM6A_uc003iug.2_Frame_Shift_Del_p.G24fs|GPM6A_uc003iuh.2_Frame_Shift_Del_p.G13fs	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	24	Helical; (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		ATAGGGAATGCCCCCCAGGCA	0.428																		23	52	---	---								-	176622885	C	-	176622885	7	5	44	1	0	1	0	1	0	0	0	0	6615	739	26	0	789	0	GPM6A	4	176622885	Frame_Shift_Del	DEL	C	TCGA-DK-A1AA-01A-11D-A13W-08	53882858	176622885	14531391	36	11401										
TTC37	9652	broad.mit.edu	37	chr5	94858955	94858955	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tttcaaatagtatagtcctcGcctaagccaggcccattttg	7	11	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr5:94858955G>A	uc003klb.2	-	18	1978	c.1708C>T	c.(1708-1710)CGA>TGA	p.R570*	TTC37_uc010jbf.1_Nonsense_Mutation_p.R522*	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	570	TPR 9.						binding			ovary(3)|pancreas(1)	4						TATAGTCCTCGCCTAAGCCAG	0.393													0	0	0	0.010818	0	29	39										A	94858955	G	A	94858955	4	1	44	1	0	0	0	0	0	1	0	0	16702	1095	38	2	3090	2	TTC37	5	94858955	Nonsense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		94858955	86056305	37	11402										
PCDHB9	56127	broad.mit.edu	37	chr5	140567962	140567962	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	atcactttccaactctgttgCtgaaaactctcctgggatag	7	11	3	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr5:140567962C>T	uc003liw.1	+	1	1070	c.1070C>T	c.(1069-1071)GCT>GTT	p.A357V		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	357	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTCTGTTGCTGAAAACTCT	0.388													0	0	0	0.005524	0	37	54										T	140567962	C	T	140567962	3	4	44	1	0	0	0	0	1	0	0	0	11549	797	28	2	1072	2	PCDHB9	5	140567962	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	45709007	140567962	40347298	38	11403										
PCDHGA12	26025	broad.mit.edu	37	chr5	140810424	140810424	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cggatgcacccagatacgctAttcagttccggaagagctgg	12	11	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr5:140810424A>G	uc003lkt.1	+	1	267	c.98A>G	c.(97-99)TAT>TGT	p.Y33C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.Y33C	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	33	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATACGCTATTCAGTTCCG	0.627													0	0	0	0.01441	0	90	107										G	140810424	A	G	140810424	3	3	44	1	0	0	0	0	1	0	0	0	11553	449	16	5	100	5	PCDHGA12	5	140810424	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	242462	140810424	40104836	39	11404										
SLC44A4	80736	broad.mit.edu	37	chr6	31842752	31842752	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tctcagcaactgagatgatgTtgctggacaggatgcagctg	13	8	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:31842752T>C	uc010jti.2	-	5	362	c.296A>G	c.(295-297)AAC>AGC	p.N99S	SLC44A4_uc011dol.1_Missense_Mutation_p.N23S|SLC44A4_uc011dom.1_Missense_Mutation_p.N99S	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	99	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	TGAGATGATGTTGCTGGACAG	0.577													0	0	0	0.01441	0	118	171										C	31842752	T	C	31842752	3	2	44	1	0	0	0	0	1	0	0	0	14638	1725	60	5	1904	5	SLC44A4	6	31842752	Missense_Mutation	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08		31842752	139272315	40	11405										
TNXB	7148	broad.mit.edu	37	chr6	32024427	32024427	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tggaagccgtacaggttcatCttgtatttatggtctggctc	11	8	3	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:32024427C>T	uc003nzl.2	-	23	8281	c.8079G>A	c.(8077-8079)AAG>AAA	p.K2693K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2753	Fibronectin type-III 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACAGGTTCATCTTGTATTTAT	0.642													0	0	0	0.010504	0	17	21										T	32024427	C	T	32024427	2	4	44	1	0	0	0	0	0	0	0	1	16343	912	32	1		1	TNXB	6	32024427	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	181675	32024427	139090640	41	11406										
ITPR3	3710	broad.mit.edu	37	chr6	33639056	33639056	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gtgtgcaggggcccccggccAtgctgcaggcctatgaggac	16	13	0	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:33639056A>T	uc011drk.1	+	21	2920	c.2701A>T	c.(2701-2703)ATG>TTG	p.M901L		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	901	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GCCCCCGGCCATGCTGCAGGC	0.632													0	0	0	0.007413	0	17	19										T	33639056	A	T	33639056	3	4	44	1	0	0	0	0	1	0	0	0	7922	217	8	5	2783	5	ITPR3	6	33639056	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	1614629	33639056	137476011	42	11407										
PKHD1	5314	broad.mit.edu	37	chr6	51497481	51497481	+	Silent	SNP	C	C	T													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttctccttcctagtcacaggCaagacagcaaatggcttgga							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:51497481C>T	uc003pah.1	-	65	11823	c.11547G>A	c.(11545-11547)TTG>TTA	p.L3849L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3849	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TAGTCACAGGCAAGACAGCAA	0.463													0	0	0	0.009096	0	4	5										T	51497481	C	T	51497481	2	4	44	1	0	0	0	0	0	0	0	1	11971	709	25	2		2	PKHD1	6	51497481	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	17858425	51497481	119617586	43	11408	51	2								
PKHD1	5314	broad.mit.edu	37	chr6	51497483	51497483	+	Silent	SNP	A	A	G													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctccttcctagtcacaggcaAgacagcaaatggcttggatc							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:51497483A>G	uc003pah.1	-	65	11821	c.11545T>C	c.(11545-11547)TTG>CTG	p.L3849L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3849	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTCACAGGCAAGACAGCAAAT	0.463													0	0	0	0.009096	0	4	5										G	51497483	A	G	51497483	2	3	44	1	0	0	0	0	0	0	0	1	11971	69	3	5		5	PKHD1	6	51497483	Silent	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	2	51497483	119617584	44	11409	51	2								
FILIP1	27145	broad.mit.edu	37	chr6	76023470	76023470	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	caacctcacccttctctattGctttattcttggcaatttgg	5	12	3	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:76023470G>T	uc003pia.2	-	5	2451	c.2078C>A	c.(2077-2079)GCA>GAA	p.A693E	FILIP1_uc003phy.1_Missense_Mutation_p.A693E|FILIP1_uc003phz.2_Missense_Mutation_p.A594E|FILIP1_uc010kbe.2_Missense_Mutation_p.A696E|FILIP1_uc003pib.1_Missense_Mutation_p.A445E	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	693	Potential.									skin(3)|ovary(1)	4						CTTCTCTATTGCTTTATTCTT	0.428													1	0	3.82274e-22	0.01441	4.56605e-22	75	131										T	76023470	G	T	76023470	3	4	44	1	0	0	0	0	1	0	0	0	5894	1319	46	4	1571	4	FILIP1	6	76023470	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	24525987	76023470	95091597	45	11410										
UTRN	7402	broad.mit.edu	37	chr6	144794859	144794859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttatcatgttcgattaggccGattcaacagtcattgagaag	9	7	3	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:144794859G>A	uc003qkt.2	+	23	3162	c.3070G>A	c.(3070-3072)GAT>AAT	p.D1024N	UTRN_uc010khq.1_Missense_Mutation_p.D1024N	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1024	Spectrin 7.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CGATTAGGCCGATTCAACAGT	0.458													0	0	0	0.005443	0	26	32										A	144794859	G	A	144794859	3	1	44	1	0	0	0	0	1	0	0	0	17100	1058	37	1	3160	1	UTRN	6	144794859	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	68771389	144794859	26320208	46	11411										
SYNE1	23345	broad.mit.edu	37	chr6	152651117	152651117	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctgagctctgccttcactctCctcagccagtccagggagcg	10	16	4	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:152651117C>A	uc010kiw.2	-	78	15305	c.14703G>T	c.(14701-14703)AGG>AGT	p.R4901S	SYNE1_uc003qot.3_Missense_Mutation_p.R4830S|SYNE1_uc003qou.3_Missense_Mutation_p.R4901S|SYNE1_uc010kiz.2_Missense_Mutation_p.R656S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4901	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTCACTCTCCTCAGCCAGT	0.517										HNSCC(10;0.0054)			1	0	6.33695e-27	0.007835	7.63987e-27	40	72										A	152651117	C	A	152651117	3	1	44	1	0	0	0	0	1	0	0	0	15442	854	30	3	12039	3	SYNE1	6	152651117	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	7856258	152651117	18463950	47	11412										
DGKB	1607	broad.mit.edu	37	chr7	14775768	14775768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	agtgaaatcatcaggaagctCggcttccaggaatgtcttca	10	9	4	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:14775768C>T	uc003ssz.2	-	4	407	c.220G>A	c.(220-222)GAG>AAG	p.E74K	DGKB_uc011jxt.1_Missense_Mutation_p.E67K|DGKB_uc003sta.2_Missense_Mutation_p.E74K|DGKB_uc011jxu.1_Missense_Mutation_p.E74K|DGKB_uc011jxv.1_Missense_Mutation_p.E74K	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	74					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TCAGGAAGCTCGGCTTCCAGG	0.358													0	0	0	0.00245	0	13	14										T	14775768	C	T	14775768	3	4	44	1	0	0	0	0	1	0	0	0	4466	893	31	1	2297	1	DGKB	7	14775768	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08		14775768	144362895	48	11413										
ABCB5	340273	broad.mit.edu	37	chr7	20744417	20744417	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	aatattagccatagatatagCacaaattcaaggagtatgta	7	5	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:20744417C>G	uc003suw.3	+	11	1619	c.1073C>G	c.(1072-1074)GCA>GGA	p.A358G	ABCB5_uc010kuh.2_Missense_Mutation_p.A803G	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	358	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						ATAGATATAGCACAAATTCAA	0.363													0	0	0	0.007413	0	17	28										G	20744417	C	G	20744417	3	3	44	1	0	0	0	0	1	0	0	0	44	710	25	4	2523	4	ABCB5	7	20744417	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	5968649	20744417	138394246	49	11414										
DNAH11	8701	broad.mit.edu	37	chr7	21788260	21788260	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tctcttggttggagttggggGcagtggcaagcagagcttgt	17	6	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:21788260G>A	uc003svc.2	+	53	8625	c.8594G>A	c.(8593-8595)GGC>GAC	p.G2865D		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2865	ATP (Potential).|AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGAGTTGGGGGCAGTGGCAAG	0.557									Kartagener_syndrome				0	0	0	0.004482	0	8	15										A	21788260	G	A	21788260	3	1	44	1	0	0	0	0	1	0	0	0	4599	1203	42	2	8801	2	DNAH11	7	21788260	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	1043843	21788260	137350403	50	11415										
HOXA2	3199	broad.mit.edu	37	chr7	27140478	27140478	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctgcatctgaaagctgcaggCaggaatctgtggagaaaacg	13	8	2	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:27140478C>T	uc003syh.2	-	2	1273	c.998G>A	c.(997-999)TGC>TAC	p.C333Y		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	333						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AAGCTGCAGGCAGGAATCTGT	0.502													0	0	0	0.01441	0	102	106										T	27140478	C	T	27140478	3	4	44	1	0	0	0	0	1	0	0	0	7292	710	25	2	136	2	HOXA2	7	27140478	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	5352218	27140478	131998185	51	11416										
C7orf25	79020	broad.mit.edu	37	chr7	42950479	42950479	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gctatggcgattcgttcacaGagcatggaatgtgcagacat	12	8	1	2	rs113806989		TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:42950479G>A	uc003thw.2	-	2	485	c.21C>T	c.(19-21)CTC>CTT	p.L7L	C7orf25_uc010kxq.2_Silent_p.L7L|C7orf25_uc003thx.3_Silent_p.L65L|C7orf25_uc010kxr.2_Silent_p.L65L	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	7										skin(1)	1						TTCGTTCACAGAGCATGGAAT	0.423													0	0	0	0.01441	0	141	172										A	42950479	G	A	42950479	2	1	44	1	0	0	0	0	0	0	0	1	2380	929	33	1		1	C7orf25	7	42950479	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	15810001	42950479	116188184	52	11417										
PNMA2	10687	broad.mit.edu	37	chr8	26365183	26365183	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cccccaggtggttttcagtcGtctccctcatgattccagcg	9	15	3	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:26365183G>A	uc003xez.2	-	3	1859	c.1089C>T	c.(1087-1089)GAC>GAT	p.D363D		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	363					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		GTTTTCAGTCGTCTCCCTCAT	0.408													0	0	0	0.01441	0	74	87										A	26365183	G	A	26365183	2	1	44	1	0	0	0	0	0	0	0	1	12154	1136	40	2		2	PNMA2	8	26365183	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		26365183	119998839	53	11418										
ADRA1A	148	broad.mit.edu	37	chr8	26721924	26721924	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ggtagaaggagcccagcgctGagaagagcacgtagcccggc	16	11	0	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:26721924G>A	uc003xfh.1	-	1	999	c.563C>T	c.(562-564)TCA>TTA	p.S188L	ADRA1A_uc003xfc.1_Missense_Mutation_p.S188L|ADRA1A_uc010lul.1_Missense_Mutation_p.S188L|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.S188L|ADRA1A_uc010lum.1_Missense_Mutation_p.S188L|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.S188L	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	188	Helical; Name=5; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	GCCCAGCGCTGAGAAGAGCAC	0.637													0	0	0	0.006122	0	16	23										A	26721924	G	A	26721924	3	1	44	1	0	0	0	0	1	0	0	0	334	1294	45	1	1136	1	ADRA1A	8	26721924	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	356741	26721924	119642098	54	11419										
IL7	3574	broad.mit.edu	37	chr8	79650798	79650798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	aacttttaataagtggagatCaaaatcaccagtgctattca	6	7	3	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:79650798C>G	uc003ybg.2	-	4	902	c.301G>C	c.(301-303)GAT>CAT	p.D101H	IL7_uc003ybe.2_Intron|IL7_uc011lfm.1_Intron|IL7_uc003ybh.2_RNA|IL7_uc003ybi.3_RNA	NM_000880	NP_000871	P13232	IL7_HUMAN	interleukin 7 precursor	101					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding				0						AAGTGGAGATCAAAATCACCA	0.353													0	0	0	0.003163	0	16	36										G	79650798	C	G	79650798	3	3	44	1	0	0	0	0	1	0	0	0	7704	826	29	1	244	1	IL7	8	79650798	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	52928874	79650798	66713224	55	11420										
TRHR	7201	broad.mit.edu	37	chr8	110100415	110100415	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tttcttaaatcccattccttCagatcctaaagaaaactcta	2	11	3	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:110100415C>T	uc003ymz.3	+	1	690	c.674C>T	c.(673-675)TCA>TTA	p.S225L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	225	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CCCATTCCTTCAGATCCTAAA	0.368													0	0	0	0.012319	0	23	26										T	110100415	C	T	110100415	3	4	44	1	0	0	0	0	1	0	0	0	16477	838	29	1	676	1	TRHR	8	110100415	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	30449617	110100415	36263607	56	11421										
TRPS1	7227	broad.mit.edu	37	chr8	116599372	116599372	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gccaagccataaataggtcgCgccagatgggcggcctccac	12	14	0	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:116599372C>A	uc003ynz.2	-	4	2976	c.2517G>T	c.(2515-2517)GCG>GCT	p.A839A	TRPS1_uc011lhy.1_Silent_p.A843A|TRPS1_uc003yny.2_Silent_p.A852A|TRPS1_uc010mcy.2_Silent_p.A839A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	839					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AAATAGGTCGCGCCAGATGGG	0.607									Langer-Giedion_syndrome				1	0	3.11337e-16	0.013726	3.49239e-16	22	26										A	116599372	C	A	116599372	2	1	44	1	0	0	0	0	0	0	0	1	16590	755	27	4		4	TRPS1	8	116599372	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	6498957	116599372	29764650	57	11422										
SPTAN1	6709	broad.mit.edu	37	chr9	131374468	131374469	+	Frame_Shift_Ins	INS	-	-	T													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gccagaaactgaaagaagccINSaacaagcagcagaacttcaa							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr9:131374468_131374469insT	uc004bvl.3	+	38	5084_5085	c.4971_4972insT	c.(4969-4974)GCCAACfs	p.A1657fs	SPTAN1_uc004bvm.3_Frame_Shift_Ins_p.A1662fs|SPTAN1_uc004bvn.3_Frame_Shift_Ins_p.A1637fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1657_1658	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAAGAAGCCAACAAGCAGCA	0.53																		82	12	---	---								T	131374469	-	T	131374468	7	5	44	1	0	1	1	0	0	0	0	0	15116	581	21	0	5136	0	SPTAN1	9	131374468	Frame_Shift_Ins	INS	-	TCGA-DK-A1AA-01A-11D-A13W-08		131374468	9838963	58	11423										
TAF5	6877	broad.mit.edu	37	chr10	105128037	105128037	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ccgcatgaccgacagactctActggccgtgctgcagttcct	10	15	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr10:105128037A>G	uc001kwv.2	+	1	314	c.291A>G	c.(289-291)CTA>CTG	p.L97L	TAF5_uc010qqq.1_Silent_p.L97L	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	97	LisH.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		GACAGACTCTACTGGCCGTGC	0.562													0	0	0	0.009096	0	4	3										G	105128037	A	G	105128037	2	3	44	1	0	0	0	0	0	0	0	1	15525	378	14	5		5	TAF5	10	105128037	Silent	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08		105128037	30406710	59	11424										
SEC23IP	11196	broad.mit.edu	37	chr10	121685711	121685711	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gtcttctgtgtgtgtgaattAtgaatcttttgaagttggcg	12	4	3	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr10:121685711A>T	uc001leu.1	+	13	2357	c.2285A>T	c.(2284-2286)TAT>TTT	p.Y762F	SEC23IP_uc010qtc.1_Missense_Mutation_p.Y551F|SEC23IP_uc009xzk.1_RNA	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	762					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TGTGTGAATTATGAATCTTTT	0.443													0	0	0	0.012213	0	31	37										T	121685711	A	T	121685711	3	4	44	1	0	0	0	0	1	0	0	0	13993	449	16	5	2335	5	SEC23IP	10	121685711	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	16557674	121685711	13849036	60	11425										
WDR11	55717	broad.mit.edu	37	chr10	122619733	122619733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ggcaccaaactatggaagaaGagctatgcagataacattct	9	8	1	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr10:122619733G>C	uc010qtf.1	+	4	703	c.465G>C	c.(463-465)AAG>AAC	p.K155N	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	155						integral to membrane					0						TATGGAAGAAGAGCTATGCAG	0.418													0	0	0	0.007291	0	29	36										C	122619733	G	C	122619733	3	2	44	1	0	0	0	0	1	0	0	0	17270	933	33	1	479	1	WDR11	10	122619733	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	934022	122619733	12915014	61	11426										
OR51D1	390038	broad.mit.edu	37	chr11	4661919	4661919	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gctgctaccacctgtagtcaAcccccttgtctatggagcca	8	15	2	0	rs141098080	byFrequency	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:4661919A>C	uc010qyk.1	+	1	899	c.899A>C	c.(898-900)AAC>ACC	p.N300T		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	300	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTGTAGTCAACCCCCTTGTC	0.532													0	0	0	0.001168	0	4	71										C	4661919	A	C	4661919	3	2	44	1	0	0	0	0	1	0	0	0	11093	43	2	5	901	5	OR51D1	11	4661919	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08		4661919	130344597	62	11427										
OR4P4	81300	broad.mit.edu	37	chr11	55405931	55405931	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tgtattatttttgttttgctAcattgctatttggatgggaa	9	3	0	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:55405931A>G	uc010rij.1	+	1	98	c.98A>G	c.(97-99)TAC>TGC	p.Y33C		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTGTTTTGCTACATTGCTATT	0.363													0	0	0	0.007413	0	20	7										G	55405931	A	G	55405931	3	3	44	1	0	0	0	0	1	0	0	0	11080	391	14	5	100	5	OR4P4	11	55405931	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	50744012	55405931	79600585	63	11428										
CEP164	22897	broad.mit.edu	37	chr11	117253629	117253629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cctgaggagaaggtggcggtCagccccaccccgccagtctc	13	16	2	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:117253629C>T	uc001prc.2	+	14	1842	c.1695C>T	c.(1693-1695)GTC>GTT	p.V565V	CEP164_uc001prb.2_Silent_p.V568V|CEP164_uc010rxk.1_Silent_p.V539V|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_5'Flank	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	565	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		AGGTGGCGGTCAGCCCCACCC	0.622													0	0	0	0.010729	0	10	20										T	117253629	C	T	117253629	2	4	44	1	0	0	0	0	0	0	0	1	3249	813	29	1		1	CEP164	11	117253629	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	61847698	117253629	17752887	64	11429										
ABCG4	64137	broad.mit.edu	37	chr11	119025544	119025544	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	cacgaggacagccctgctctCtggcgggcagaggaagcgtc	15	13	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:119025544C>T	uc001pvs.2	+	6	941	c.605C>T	c.(604-606)TCT>TTT	p.S202F	ABCG4_uc009zar.2_Missense_Mutation_p.S202F	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	202	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCCCTGCTCTCTGGCGGGCAG	0.622													0	0	0	0.01441	0	64	90										T	119025544	C	T	119025544	3	4	44	1	0	0	0	0	1	0	0	0	70	913	32	1	623	1	ABCG4	11	119025544	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	1771915	119025544	15980972	65	11430										
KRT84	3890	broad.mit.edu	37	chr12	52777464	52777464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ccagcacctccaactgcctcCgcaggttggtgatgtagctc	10	15	0	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:52777464C>T	uc001sah.1	-	2	713	c.665G>A	c.(664-666)CGG>CAG	p.R222Q		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	222	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAACTGCCTCCGCAGGTTGGT	0.542													0	0	0	0.01441	0	66	75										T	52777464	C	T	52777464	3	4	44	1	0	0	0	0	1	0	0	0	8498	652	23	2	1169	2	KRT84	12	52777464	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08		52777464	81074431	66	11431										
HNRNPA1	3178	broad.mit.edu	37	chr12	54675636	54675636	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttgggtttgtcacatatgccActgtggaggaggtggatgca	15	6	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:54675636A>G	uc001sfl.2	+	3	294	c.190A>G	c.(190-192)ACT>GCT	p.T64A	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.T64A|HNRNPA1_uc009zng.2_Missense_Mutation_p.T64A|HNRNPA1_uc009znh.2_Missense_Mutation_p.T64A|HNRNPA1_uc009zni.2_Missense_Mutation_p.T64A|HNRNPA1_uc001sfn.2_Missense_Mutation_p.T64A|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.T19A|HNRNPA1_uc009znj.1_Missense_Mutation_p.T19A	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	64	Globular A domain.|RRM 1.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						CACATATGCCACTGTGGAGGA	0.483													0	0	0	0.01441	0	50	49										G	54675636	A	G	54675636	3	3	44	1	0	0	0	0	1	0	0	0	7257	159	6	5	200	5	HNRNPA1	12	54675636	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	1898172	54675636	79176259	67	11432										
ERBB3	2065	broad.mit.edu	37	chr12	56478854	56478854	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	taccattgcccaacctccgcGtggtgcgagggacccaggtc	12	15	0	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:56478854G>T	uc001sjh.2	+	3	503	c.310G>T	c.(310-312)GTG>TTG	p.V104L	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45L|ERBB3_uc001sjg.2_Missense_Mutation_p.V104L	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517													1	0	3.60193e-44	0.01441	4.42522e-44	94	135										T	56478854	G	T	56478854	3	4	44	1	0	0	0	0	1	0	0	0	5208	1145	40	4	320	4	ERBB3	12	56478854	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	1803218	56478854	77373041	68	11433										
STAC3	246329	broad.mit.edu	37	chr12	57637894	57637894	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gtccttcttgagagtgatctGccctatctcgcggttcccca	9	14	3	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:57637894G>A	uc001snp.2	-	11	1168	c.973C>T	c.(973-975)CAG>TAG	p.Q325*	STAC3_uc009zpl.2_Missense_Mutation_p.A42V|STAC3_uc001snq.2_Nonsense_Mutation_p.Q286*|STAC3_uc010srm.1_Nonsense_Mutation_p.Q139*	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	325	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						AGAGTGATCTGCCCTATCTCG	0.562											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	20	30										A	57637894	G	A	57637894	4	1	44	1	0	0	0	0	0	1	0	0	15240	1328	46	2	129	2	STAC3	12	57637894	Nonsense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	1159040	57637894	76214001	69	11434										
NR2C1	7181	broad.mit.edu	37	chr12	95434302	95434302	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gcccagtgcattgataagaaCagcagtctggaggcagactc	12	10	1	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:95434302C>A	uc001tdm.3	-	10	1459	c.1203G>T	c.(1201-1203)CTG>CTT	p.L401L	NR2C1_uc010suu.1_Silent_p.L401L|NR2C1_uc001tdo.3_Silent_p.L401L|NR2C1_uc001tdn.3_Silent_p.L401L	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	401					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						TTGATAAGAACAGCAGTCTGG	0.423													1	0	9.65021e-13	0.010818	1.064e-12	32	40										A	95434302	C	A	95434302	2	1	44	1	0	0	0	0	0	0	0	1	10622	465	17	4		4	NR2C1	12	95434302	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	37796408	95434302	38417593	70	11435										
FREM2	341640	broad.mit.edu	37	chr13	39420751	39420751	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	atgtggaatactctgtggatGagagtgctggctatgtggaa	15	4	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr13:39420751G>A	uc001uwv.2	+	7	6370	c.6061G>A	c.(6061-6063)GAG>AAG	p.E2021K	FREM2_uc001uww.2_Missense_Mutation_p.E107K	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2021	Extracellular (Potential).|Calx-beta 3.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTCTGTGGATGAGAGTGCTGG	0.433													0	0	0	0.010729	0	11	19										A	39420751	G	A	39420751	3	1	44	1	0	0	0	0	1	0	0	0	6045	1291	45	1	6087	1	FREM2	13	39420751	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		39420751	75749127	71	11436										
LPAR6	10161	broad.mit.edu	37	chr13	48986079	48986079	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ggcttctgaggcattgttacCctgagagtgggtagactgaa	14	7	1	4			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr13:48986079C>G	uc010acu.2	-	1	1575	c.481G>C	c.(481-483)GGT>CGT	p.G161R	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Missense_Mutation_p.G161R|LPAR6_uc001vcf.2_Missense_Mutation_p.G161R	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	161	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GCATTGTTACCCTGAGAGTGG	0.363													0	0	0	0.000602	0	5	5										G	48986079	C	G	48986079	3	3	44	1	0	0	0	0	1	0	0	0	8909	623	22	4	557	4	LPAR6	13	48986079	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	9565328	48986079	66183799	72	11437										
MYH7	4625	broad.mit.edu	37	chr14	23897051	23897051	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tggccttgaaggtcatgtcgGtggccttggggaacatgcac	15	9	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr14:23897051G>A	uc001wjx.2	-	16	1737	c.1631C>T	c.(1630-1632)ACC>ATC	p.T544I		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	544	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGTCATGTCGGTGGCCTTGGG	0.552													0	0	0	0.00623	0	40	67										A	23897051	G	A	23897051	3	1	44	1	0	0	0	0	1	0	0	0	10039	1261	44	2	4276	2	MYH7	14	23897051	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		23897051	83452489	73	11438										
EHD4	30844	broad.mit.edu	37	chr15	42211817	42211817	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gcaggacctggcagaagtcaTagcctgggtggagagaagga	17	7	1	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr15:42211817T>C	uc001zot.2	-	4	578	c.515A>G	c.(514-516)TAT>TGT	p.Y172C		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	172					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GCAGAAGTCATAGCCTGGGTG	0.562													0	0	0	0.014323	0	20	22										C	42211817	T	C	42211817	3	2	44	1	0	0	0	0	1	0	0	0	4980	1406	49	5	1122	5	EHD4	15	42211817	Missense_Mutation	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08		42211817	60319575	74	11439										
TSC2	7249	broad.mit.edu	37	chr16	2121804	2121804	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gggagccagagagaggctctGagaagaagaccagcggcccc	16	11	1	5			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:2121804G>T	uc002con.2	+	19	2072	c.1966G>T	c.(1966-1968)GAG>TAG	p.E656*	TSC2_uc010bsd.2_Nonsense_Mutation_p.E656*|TSC2_uc002coo.2_Nonsense_Mutation_p.E656*|TSC2_uc010uvv.1_Nonsense_Mutation_p.E619*|TSC2_uc010uvw.1_Nonsense_Mutation_p.E607*|TSC2_uc002cop.2_Nonsense_Mutation_p.E456*	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	656					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GAGAGGCTCTGAGAAGAAGAC	0.667			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				1	0	0.000602214	0.000602	0.000631591	5	12										T	2121804	G	T	2121804	4	4	44	1	0	0	0	0	0	1	0	0	16603	1291	45	3	2036	3	TSC2	16	2121804	Nonsense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		2121804	88232949	75	11440										
XPO6	23214	broad.mit.edu	37	chr16	28112860	28112860	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctggtcaggaactctgggagGaaggcggcaaagaagccatc	15	9	2	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:28112860G>A	uc002dpa.1	-	23	3696	c.3195C>T	c.(3193-3195)TTC>TTT	p.F1065F	XPO6_uc002dpb.1_Silent_p.F1051F|XPO6_uc010vcp.1_Silent_p.F1064F	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	1065					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						ACTCTGGGAGGAAGGCGGCAA	0.542													0	0	0	0.013726	0	34	51										A	28112860	G	A	28112860	2	1	44	1	0	0	0	0	0	0	0	1	17445	1165	41	1		1	XPO6	16	28112860	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	25991056	28112860	62241893	76	11441										
NETO2	81831	broad.mit.edu	37	chr16	47163140	47163140	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	aaatcgttcaaataccttccAaaatgtagatacactccttg	4	10	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:47163140A>G	uc002eer.1	-	3	612	c.227T>C	c.(226-228)TTG>TCG	p.L76S	NETO2_uc010vgf.1_5'Flank|NETO2_uc002ees.1_Missense_Mutation_p.L76S	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	76	Extracellular (Potential).|CUB 1.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				AATACCTTCCAAAATGTAGAT	0.348										HNSCC(25;0.065)			0	0	0	0.013114	0	44	60										G	47163140	A	G	47163140	3	3	44	1	0	0	0	0	1	0	0	0	10340	131	5	5	1378	5	NETO2	16	47163140	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	19050280	47163140	43191613	77	11442										
SF3B3	23450	broad.mit.edu	37	chr16	70594445	70594445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tactcgcactcggtacctggGgtcccgtcctgtgaagctct	11	14	1	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:70594445G>A	uc002ezf.2	+	16	2295	c.2084G>A	c.(2083-2085)GGG>GAG	p.G695E		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	695					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CGGTACCTGGGGTCCCGTCCT	0.532													0	0	0	0.01441	0	47	49										A	70594445	G	A	70594445	3	1	44	1	0	0	0	0	1	0	0	0	14152	1232	43	2	2142	2	SF3B3	16	70594445	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	23431305	70594445	19760308	78	11443										
CDH13	1012	broad.mit.edu	37	chr16	83636094	83636094	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	aagtatgaactgatcatcgaGgctcaagatatggctggact	11	7	2	3			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:83636094G>C	uc002fgx.2	+	8	1116	c.996G>C	c.(994-996)GAG>GAC	p.E332D	CDH13_uc010vns.1_Missense_Mutation_p.E379D|CDH13_uc010vnt.1_Missense_Mutation_p.E78D|CDH13_uc010vnu.1_Missense_Mutation_p.E293D	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	332	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGATCATCGAGGCTCAAGATA	0.418													0	0	0	0.01441	0	55	102										C	83636094	G	C	83636094	3	2	44	1	0	0	0	0	1	0	0	0	3099	991	35	4	1026	4	CDH13	16	83636094	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	13041649	83636094	6718659	79	11444										
CARD14	79092	broad.mit.edu	37	chr17	78166305	78166305	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tggcctgtctttggcagctcAagcaggaagccaggaccagg	14	11	2	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr17:78166305A>G	uc002jxw.1	+	9	1438	c.1243A>G	c.(1243-1245)AAG>GAG	p.K415E	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.K415E|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Missense_Mutation_p.K178E|CARD14_uc010dhu.1_Missense_Mutation_p.K213E	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	415					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TTGGCAGCTCAAGCAGGAAGC	0.607													0	0	0	0.006999	0	31	59										G	78166305	A	G	78166305	3	3	44	1	0	0	0	0	1	0	0	0	2646	131	5	5	1273	5	CARD14	17	78166305	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08		78166305	3028905	80	11445										
AATK	9625	broad.mit.edu	37	chr17	79095182	79095182	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	actgctgggtgcctccacctCgggagagctgctgctgccat	13	14	0	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr17:79095182C>T	uc010dia.2	-	11	2634	c.2554G>A	c.(2554-2556)GAG>AAG	p.E852K	AATK_uc010dhz.2_RNA	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	852						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCCTCCACCTCGGGAGAGCTG	0.667													0	0	0	0.008291	0	11	6										T	79095182	C	T	79095182	3	4	44	1	0	0	0	0	1	0	0	0	26	893	31	1	1586	1	AATK	17	79095182	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	928877	79095182	2100028	81	11446										
LAMA1	284217	broad.mit.edu	37	chr18	6961676	6961676	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	tgttcgtggtggcaaatgttAccagccattctgattctggt	11	8	2	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr18:6961676A>C	uc002knm.2	-	53	7629	c.7535T>G	c.(7534-7536)GTA>GGA	p.V2512G	LAMA1_uc002knl.2_5'UTR|LAMA1_uc010wzj.1_Missense_Mutation_p.V1988G	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2512	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCAAATGTTACCAGCCATTC	0.552													0	0	0	0.006214	0	4	20										C	6961676	A	C	6961676	3	2	44	1	0	0	0	0	1	0	0	0	8605	391	14	5	1736	5	LAMA1	18	6961676	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08		6961676	71115572	82	11447										
FAM59A	64762	broad.mit.edu	37	chr18	29867460	29867460	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	agctgagcgaattgggcacgTggttgtggccagagcaccga	16	9	0	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr18:29867460T>A	uc002kxl.2	-	4	1156	c.1100A>T	c.(1099-1101)CAC>CTC	p.H367L	FAM59A_uc002kxk.1_Missense_Mutation_p.H367L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	367										ovary(1)|skin(1)	2						ATTGGGCACGTGGTTGTGGCC	0.552													0	0	0	0.003271	0	31	42										A	29867460	T	A	29867460	3	1	44	1	0	0	0	0	1	0	0	0	5592	1696	59	5	1539	5	FAM59A	18	29867460	Missense_Mutation	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08	22905784	29867460	48209788	83	11448										
PIP5K1C	23396	broad.mit.edu	37	chr19	3664824	3664824	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	aggggagccgaggaaccttcTtgtaggtggtttcgccggat	16	8	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:3664824T>C	uc002lyj.1	-	3	272	c.215A>G	c.(214-216)AAG>AGG	p.K72R	PIP5K1C_uc010xhq.1_Missense_Mutation_p.K72R|PIP5K1C_uc010xhr.1_Missense_Mutation_p.K72R	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	72					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		AGGAACCTTCTTGTAGGTGGT	0.642													0	0	0	0.01441	0	66	91										C	3664824	T	C	3664824	3	2	44	1	0	0	0	0	1	0	0	0	11941	1609	56	5	1855	5	PIP5K1C	19	3664824	Missense_Mutation	SNP	T	TCGA-DK-A1AA-01A-11D-A13W-08		3664824	55464159	84	11449										
MUC16	94025	broad.mit.edu	37	chr19	9063340	9063340	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttcagaggtggccagtatttCaactgaggtgctgctcaaat	11	8	3	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:9063340C>T	uc002mkp.2	-	3	24310	c.24106G>A	c.(24106-24108)GAA>AAA	p.E8036K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8038	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCAGTATTTCAACTGAGGTG	0.463													0	0	0	0.005443	0	25	49										T	9063340	C	T	9063340	3	4	44	1	0	0	0	0	1	0	0	0	9973	835	29	1	19745	1	MUC16	19	9063340	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	5398516	9063340	50065643	85	11450										
DCAF15	90379	broad.mit.edu	37	chr19	14070852	14070852	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ggcctgctgctcctggccttCccgtcccccactgaggaggg	13	17	0	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:14070852C>T	uc002mxt.2	+	10	1503	c.1497C>T	c.(1495-1497)TTC>TTT	p.F499F	DCAF15_uc002mxu.2_RNA	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	499										central_nervous_system(1)	1						TCCTGGCCTTCCCGTCCCCCA	0.657											OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004656	0	24	25										T	14070852	C	T	14070852	2	4	44	1	0	0	0	0	0	0	0	1	4267	854	30	1		1	DCAF15	19	14070852	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	5007512	14070852	45058131	86	11451										
LPHN1	22859	broad.mit.edu	37	chr19	14272185	14272186	+	Frame_Shift_Ins	INS	-	-	C													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gctgggtggccggccactggINSacccgccgtacctctcgggg							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:14272185_14272186insC	uc010xnn.1	-	7	1759_1760	c.1463_1464insG	c.(1462-1464)GTCfs	p.V488fs	LPHN1_uc010xno.1_Frame_Shift_Ins_p.V483fs|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	488	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						CCGGCCACTGGACCCGCCGTAC	0.713																		8	23	---	---								C	14272186	-	C	14272185	7	5	44	1	0	1	1	0	0	0	0	0	8915	1161	41	0	3032	0	LPHN1	19	14272185	Frame_Shift_Ins	INS	-	TCGA-DK-A1AA-01A-11D-A13W-08	201333	14272185	44856798	87	11452										
TSHZ3	57616	broad.mit.edu	37	chr19	31770348	31770348	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ttgttgtacacggccttcatCtgctccaggctatccgacac	8	14	2	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:31770348C>A	uc002nsy.3	-	2	416	c.351G>T	c.(349-351)CAG>CAT	p.Q117H		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	117					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CGGCCTTCATCTGCTCCAGGC	0.507													1	0	1.00001e-27	0.009718	1.21699e-27	42	50										A	31770348	C	A	31770348	3	1	44	1	0	0	0	0	1	0	0	0	16622	912	32	3	2898	3	TSHZ3	19	31770348	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	17498163	31770348	27358635	88	11453										
SUPT5H	6829	broad.mit.edu	37	chr19	39950550	39950550	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	agattggggaggaacgggccAcggccatttccttgatgcgc	15	10	0	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:39950550A>T	uc002olo.3	+	10	753	c.574A>T	c.(574-576)ACG>TCG	p.T192S	SUPT5H_uc002olp.3_Missense_Mutation_p.T192S|SUPT5H_uc002olq.3_Missense_Mutation_p.T188S|SUPT5H_uc002oln.3_Missense_Mutation_p.T192S|SUPT5H_uc002olr.3_Missense_Mutation_p.T192S	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	192	Interaction with SUPT4H1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGAACGGGCCACGGCCATTTC	0.547													0	0	0	0.005443	0	26	53										T	39950550	A	T	39950550	3	4	44	1	0	0	0	0	1	0	0	0	15396	159	6	5	608	5	SUPT5H	19	39950550	Missense_Mutation	SNP	A	TCGA-DK-A1AA-01A-11D-A13W-08	8180202	39950550	19178433	89	11454										
IRGC	56269	broad.mit.edu	37	chr19	44222905	44222905	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gtcacgggcgagtcgggcgcGggcaagtcctccctcatcaa	14	14	3	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:44222905G>A	uc002oxh.2	+	2	342	c.195G>A	c.(193-195)GCG>GCA	p.A65A		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	65	GTP.					membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				AGTCGGGCGCGGGCAAGTCCT	0.701													0	0	0	0.009096	0	4	77										A	44222905	G	A	44222905	2	1	44	1	0	0	0	0	0	0	0	1	7838	1103	39	2		2	IRGC	19	44222905	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	4272355	44222905	14906078	90	11455										
KIR3DL1	3811	broad.mit.edu	37	chr19	55377274	55377274	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ctccaggtatctgcagacacCtgcatgttctgattgggacc	10	12	2	2			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:55377274C>T	uc002qhl.3	+	7	1078	c.1015C>T	c.(1015-1017)CTG>TTG	p.L339L	KIR3DL2_uc010esh.2_Silent_p.L322L|KIR3DL2_uc002qho.3_Silent_p.L339L			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	339	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CTGCAGACACCTGCATGTTCT	0.353													0	0	0	0.01441	0	44	60										T	55377274	C	T	55377274	2	4	44	1	0	0	0	0	0	0	0	1	8320	680	24	2		2	KIR3DL1	19	55377274	Silent	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08	11154369	55377274	3751709	91	11456										
TMC2	117532	broad.mit.edu	37	chr20	2542536	2542536	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	ggcctccagtgcctctggtgGggagtccctgtccgaggagg	17	12	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr20:2542536G>T	uc002wgf.1	+	4	449	c.434G>T	c.(433-435)GGG>GTG	p.G145V	TMC2_uc002wgg.1_Missense_Mutation_p.G129V|TMC2_uc010zpw.1_5'UTR|TMC2_uc010zpx.1_5'UTR	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	145	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GCCTCTGGTGGGGAGTCCCTG	0.617													1	0	1.7489e-18	0.011902	2.01436e-18	43	55										T	2542536	G	T	2542536	3	4	44	1	0	0	0	0	1	0	0	0	15982	1232	43	4	448	4	TMC2	20	2542536	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		2542536	60482984	92	11457										
ZBTB46	140685	broad.mit.edu	37	chr20	62421844	62421844	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gccaggtgcgctgagtacatGaagtcgatgatggccttgaa	14	8	0	4			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr20:62421844G>C	uc002ygv.1	-	2	468	c.267C>G	c.(265-267)TTC>TTG	p.F89L	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	89	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CTGAGTACATGAAGTCGATGA	0.612													0	0	0	0.007413	0	19	37										C	62421844	G	C	62421844	3	2	44	1	0	0	0	0	1	0	0	0	17544	1281	45	1	1518	1	ZBTB46	20	62421844	Missense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	59879308	62421844	603676	93	11458										
LMF2	91289	broad.mit.edu	37	chr22	50943119	50943119	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gcaccacaaccgggggcggcCggctcaggttcccaggcttg	15	15	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr22:50943119C>G	uc003blp.2	-	11	1506	c.1475G>C	c.(1474-1476)CGG>CCG	p.R492P	LMF2_uc010hba.2_Missense_Mutation_p.R314P|LMF2_uc003blo.2_Missense_Mutation_p.R467P	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	492						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGGGCGGCCGGCTCAGGTT	0.692													0	0	0	0.014323	0	21	29										G	50943119	C	G	50943119	3	3	44	1	0	0	0	0	1	0	0	0	8846	652	23	4	664	4	LMF2	22	50943119	Missense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08		50943119	361447	94	11459										
KDM6A	7403	broad.mit.edu	37	chrX	44913157	44913157	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	agtatctccaaaagtccttgGaagcagatcctaattctggc	8	10	2	1			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrX:44913157G>T	uc004dge.3	+	10	1207	c.832G>T	c.(832-834)GAA>TAA	p.E278*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.E278*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.E278*|KDM6A_uc011mla.1_Nonsense_Mutation_p.E278*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.E278*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.E27*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	278	TPR 5.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAGTCCTTGGAAGCAGATCC	0.408			D|N|F|S		renal|oesophageal SCC|MM								1	0	7.47603e-22	0.01441	8.84777e-22	53	9										T	44913157	G	T	44913157	4	4	44	1	0	0	0	0	0	1	0	0	8137	1175	41	3	870	3	KDM6A	23	44913157	Nonsense_Mutation	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08		44913157	110357403	95	11460										
THOC2	57187	broad.mit.edu	37	chrX	122753270	122753270	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	acctttgctgaagattccttGagttcgatgagactgtcctg	10	9	0	4			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrX:122753270G>C	uc004etu.2	-	33	4325	c.4293C>G	c.(4291-4293)CTC>CTG	p.L1431L	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Silent_p.L252L	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1431	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						AAGATTCCTTGAGTTCGATGA	0.393													0	0	0	0.001168	0	5	1										C	122753270	G	C	122753270	2	2	44	1	0	0	0	0	0	0	0	1	15862	1277	45	1		1	THOC2	23	122753270	Silent	SNP	G	TCGA-DK-A1AA-01A-11D-A13W-08	77840113	122753270	32517290	96	11461										
STAG2	10735	broad.mit.edu	37	chrX	123211880	123211881	+	Frame_Shift_Ins	INS	-	-	T													0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	atagacaaaattcagtgtgcINStaagacccttattctcagtc							TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrX:123211880_123211881insT	uc004etz.3	+	26	3086_3087	c.2747_2748insT	c.(2746-2748)GCTfs	p.A916fs	STAG2_uc004eua.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004eub.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004euc.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004eud.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004eue.2_Frame_Shift_Ins_p.A916fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	916					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						ATTCAGTGTGCTAAGACCCTTA	0.322																		47	6	---	---								T	123211881	-	T	123211880	7	5	44	1	0	1	1	0	0	0	0	0	15242	797	28	0	2845	0	STAG2	23	123211880	Frame_Shift_Ins	INS	-	TCGA-DK-A1AA-01A-11D-A13W-08	458610	123211880	32058680	97	11462										
UTY	7404	broad.mit.edu	37	chrY	15591422	15591422	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.154639175257732	15	0.00167803125518541	2.3171114599686	4.12867132867133	1.79271255060729	0.499792039464139	0.689830814103477	9	gccaccaagcgcctccctttCctcgactgtcaggctaacag	8	17	1	0			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrY:15591422C>A	uc004fsx.1	-	1	1129	c.124G>T	c.(124-126)GAA>TAA	p.E42*	UTY_uc004fsy.2_Nonsense_Mutation_p.E42*|UTY_uc004fsz.2_Nonsense_Mutation_p.E42*	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	42					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCCTCCCTTTCCTCGACTGTC	0.607													1	0	7.88262e-20	0.00333	9.16089e-20	20	2										A	15591422	C	A	15591422	4	1	44	1	0	0	0	0	0	1	0	0	17104	864	30	3	4294	3	UTY	24	15591422	Nonsense_Mutation	SNP	C	TCGA-DK-A1AA-01A-11D-A13W-08		15591422	43782144	98	11463										
MTHFR	4524	broad.mit.edu	37	chr1	11861287	11861287	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagatggcccgtgatctcctCcaggcgctgacggcagcagg	14	14	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:11861287C>T	uc001atc.1	-	3	590	c.406G>A	c.(406-408)GAG>AAG	p.E136K	MTHFR_uc001atb.1_Missense_Mutation_p.E159K	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	136					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	GTGATCTCCTCCAGGCGCTGA	0.612													0	0	0	0.049695	0	17	96										T	11861287	C	T	11861287	3	4	45	1	0	0	0	0	1	0	0	0	9931	864	30	1	1604	1	MTHFR	1	11861287	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		11861287	237389334	1	11464										
PHACTR4	65979	broad.mit.edu	37	chr1	28786756	28786756	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aatatctatgcgaaagccaaGagaagagctggttaaaagag	11	5	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:28786756G>C	uc001bpw.2	+	4	506	c.224G>C	c.(223-225)AGA>ACA	p.R75T	PHACTR4_uc001bpu.2_Missense_Mutation_p.R75T|PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.R59T|PHACTR4_uc001bpy.2_Missense_Mutation_p.R85T	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	75	RPEL 1.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		CGAAAGCCAAGAGAAGAGCTG	0.388													0	0	0	0.058154	0	8	39										C	28786756	G	C	28786756	3	2	45	1	0	0	0	0	1	0	0	0	11812	942	33	1	284	1	PHACTR4	1	28786756	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	16925469	28786756	220463865	2	11465										
C1orf168	199920	broad.mit.edu	37	chr1	57233546	57233546	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acaggttaatggagttgccaGagtgtctcagatatgaaatt	11	5	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:57233546G>A	uc001cym.3	-	5	1425	c.1019C>T	c.(1018-1020)TCT>TTT	p.S340F	C1orf168_uc009vzu.1_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	340										ovary(3)|skin(2)	5						GGAGTTGCCAGAGTGTCTCAG	0.368													0	0	0	0.0918	0	23	107										A	57233546	G	A	57233546	3	1	45	1	0	0	0	0	1	0	0	0	2012	942	33	1	1231	1	C1orf168	1	57233546	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	28446790	57233546	192017075	3	11466										
C1orf168	199920	broad.mit.edu	37	chr1	57233561	57233561	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgccagagtgtctcagatatGaaattgttgcctcgtaatta	9	7	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:57233561G>A	uc001cym.3	-	5	1410	c.1004C>T	c.(1003-1005)TCA>TTA	p.S335L	C1orf168_uc009vzu.1_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	335										ovary(3)|skin(2)	5						TCTCAGATATGAAATTGTTGC	0.353													0	0	0	0.108266	0	24	109										A	57233561	G	A	57233561	3	1	45	1	0	0	0	0	1	0	0	0	2012	1294	45	1	1246	1	C1orf168	1	57233561	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	15	57233561	192017060	4	11467										
DIRAS3	9077	broad.mit.edu	37	chr1	68512369	68512369	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttctcgggctcctggaggccGgtggtgggctttttcttgta	15	9	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:68512369G>A	uc001ded.2	-	2	907	c.612C>T	c.(610-612)ACC>ACT	p.T204T	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	204					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						CCTGGAGGCCGGTGGTGGGCT	0.527													0	0	0	0.139131	0	51	120										A	68512369	G	A	68512369	2	1	45	1	0	0	0	0	0	0	0	1	4532	1103	39	2		2	DIRAS3	1	68512369	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	11278808	68512369	180738252	5	11468										
SSX2IP	117178	broad.mit.edu	37	chr1	85127956	85127956	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agagaaatcatttcctttttCatttgttgaagaaccttctt	5	7	3	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:85127956C>G	uc001dkh.2	-	9	1127	c.852G>C	c.(850-852)ATG>ATC	p.M284I	SSX2IP_uc001dkf.2_Missense_Mutation_p.M257I|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Missense_Mutation_p.M257I|SSX2IP_uc001dki.2_Missense_Mutation_p.M284I|SSX2IP_uc010osa.1_Missense_Mutation_p.M257I|SSX2IP_uc001dkj.2_Missense_Mutation_p.M284I|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Missense_Mutation_p.M280I	NM_014021	NP_054740	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting	284	Potential.				cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTTCCTTTTTCATTTGTTGAA	0.323													0	0	0	0.02938	0	7	231										G	85127956	C	G	85127956	3	3	45	1	0	0	0	0	1	0	0	0	15203	826	29	1	1020	1	SSX2IP	1	85127956	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	16615587	85127956	164122665	6	11469										
TGFBR3	7049	broad.mit.edu	37	chr1	92185667	92185667	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggaaaggaaacggaaggcctCcattttggccttcccctccc	10	14	0	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:92185667C>G	uc001doh.2	-	9	1662	c.1196G>C	c.(1195-1197)GGA>GCA	p.G399A	TGFBR3_uc009wde.2_Missense_Mutation_p.G176A|TGFBR3_uc010osy.1_Missense_Mutation_p.G357A|TGFBR3_uc001doi.2_Missense_Mutation_p.G398A|TGFBR3_uc001doj.2_Missense_Mutation_p.G398A	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	399	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CGGAAGGCCTCCATTTTGGCC	0.582													0	0	0	0.116897	0	27	57										G	92185667	C	G	92185667	3	3	45	1	0	0	0	0	1	0	0	0	15820	855	30	1	1395	1	TGFBR3	1	92185667	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	7057711	92185667	157064954	7	11470										
RTCD1	8634	broad.mit.edu	37	chr1	100732130	100732130	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttgagctgtctcctaggcctCcccttgcgggtgcagaagat	12	12	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:100732130C>T	uc001dtc.2	+	2	314	c.96C>T	c.(94-96)CTC>CTT	p.L32L	RTCD1_uc010ouh.1_Silent_p.L32L|RTCD1_uc001dtd.2_Silent_p.L32L	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	32					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		TCCTAGGCCTCCCCTTGCGGG	0.637													0	0	0	0.021553	0	5	13										T	100732130	C	T	100732130	2	4	45	1	0	0	0	0	0	0	0	1	13718	842	30	1		1	RTCD1	1	100732130	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	8546463	100732130	148518491	8	11471										
ANKRD35	148741	broad.mit.edu	37	chr1	145558885	145558885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgggtgggcacgcagctatCtgctcacagctgctgcagcg	14	13	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:145558885C>G	uc001eob.1	+	7	612	c.504C>G	c.(502-504)ATC>ATG	p.I168M	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.I11M	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	168	ANK 4.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACGCAGCTATCTGCTCACAGC	0.572													0	0	0	0.0918	0	26	90										G	145558885	C	G	145558885	3	3	45	1	0	0	0	0	1	0	0	0	664	903	32	1	530	1	ANKRD35	1	145558885	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	44826755	145558885	103691736	9	11472										
CGN	57530	broad.mit.edu	37	chr1	151491775	151491775	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agccagaacctgagtcctctCagtggctttagccgttctcg	10	13	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:151491775C>T	uc009wmw.2	+	2	924	c.780C>T	c.(778-780)CTC>CTT	p.L260L		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	254	Interacts with ZO-2.|Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGAGTCCTCTCAGTGGCTTTA	0.582													0	0	0	0.105934	0	13	40										T	151491775	C	T	151491775	2	4	45	1	0	0	0	0	0	0	0	1	3303	813	29	1		1	CGN	1	151491775	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	5932890	151491775	97758846	10	11473										
ADAM15	8751	broad.mit.edu	37	chr1	155033250	155033250	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	catgcatagggcagcccaatCtggtccctctgaacggccag	11	14	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:155033250C>T	uc001fgr.1	+	19	2320	c.2219C>T	c.(2218-2220)TCT>TTT	p.S740F	EFNA3_uc010pew.1_5'Flank|ADAM15_uc001fgq.1_Missense_Mutation_p.S425F|ADAM15_uc010peu.1_Missense_Mutation_p.S757F|ADAM15_uc001fgt.1_Missense_Mutation_p.S740F|ADAM15_uc010pev.1_Missense_Mutation_p.S750F|ADAM15_uc001fgs.1_Intron|ADAM15_uc001fgu.1_Missense_Mutation_p.S740F|ADAM15_uc001fgw.1_Missense_Mutation_p.S740F|ADAM15_uc001fgv.1_Missense_Mutation_p.S740F|ADAM15_uc001fgx.1_Intron|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_Missense_Mutation_p.S31F|EFNA4_uc001fhc.2_5'Flank|EFNA4_uc001fhd.2_5'Flank|EFNA4_uc001fhe.2_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	740	Cytoplasmic (Potential).				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GCAGCCCAATCTGGTCCCTCT	0.602													0	0	0	0.038147	0	7	46										T	155033250	C	T	155033250	3	4	45	1	0	0	0	0	1	0	0	0	237	913	32	1	2293	1	ADAM15	1	155033250	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	3541475	155033250	94217371	11	11474										
YY1AP1	55249	broad.mit.edu	37	chr1	155629585	155629585	+	Missense_Mutation	SNP	C	C	T													0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagagcttgccttccctcctCtgttttcacaacggtccagc							TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:155629585C>T	uc001fln.2	-	11	2278	c.2254G>A	c.(2254-2256)GAG>AAG	p.E752K	YY1AP1_uc001flg.2_Missense_Mutation_p.E491K|YY1AP1_uc010pgg.1_Missense_Mutation_p.E591K|YY1AP1_uc010pgh.1_Missense_Mutation_p.E695K|YY1AP1_uc010pgi.1_Missense_Mutation_p.E844K|YY1AP1_uc001flh.2_Missense_Mutation_p.E824K|YY1AP1_uc009wqt.2_Missense_Mutation_p.E675K|YY1AP1_uc001flk.2_Missense_Mutation_p.E695K|YY1AP1_uc001fll.2_Missense_Mutation_p.E706K|YY1AP1_uc009wqv.2_Missense_Mutation_p.E423K|YY1AP1_uc001flm.2_Missense_Mutation_p.E695K|YY1AP1_uc001fli.2_Missense_Mutation_p.E706K|YY1AP1_uc009wqu.2_Missense_Mutation_p.E539K|YY1AP1_uc001flj.2_Missense_Mutation_p.E686K|YY1AP1_uc009wqw.2_Missense_Mutation_p.E675K|YY1AP1_uc001flo.2_Missense_Mutation_p.E640K|YY1AP1_uc001flp.2_Missense_Mutation_p.E706K	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	752					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CTTCCCTCCTCTGTTTTCACA	0.537													0	0	0	0.134883	0	30	99										T	155629585	C	T	155629585	3	4	45	1	0	0	0	0	1	0	0	0	17505	922	32	1	140	1	YY1AP1	1	155629585	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	596335	155629585	93621036	12	11475	52	2								
YY1AP1	55249	broad.mit.edu	37	chr1	155629592	155629592	+	Silent	SNP	C	C	T													0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgccttccctcctctgttttCacaacggtccagcgataggc							TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:155629592C>T	uc001fln.2	-	11	2271	c.2247G>A	c.(2245-2247)GTG>GTA	p.V749V	YY1AP1_uc001flg.2_Silent_p.V488V|YY1AP1_uc010pgg.1_Silent_p.V588V|YY1AP1_uc010pgh.1_Silent_p.V692V|YY1AP1_uc010pgi.1_Silent_p.V841V|YY1AP1_uc001flh.2_Silent_p.V821V|YY1AP1_uc009wqt.2_Silent_p.V672V|YY1AP1_uc001flk.2_Silent_p.V692V|YY1AP1_uc001fll.2_Silent_p.V703V|YY1AP1_uc009wqv.2_Silent_p.V420V|YY1AP1_uc001flm.2_Silent_p.V692V|YY1AP1_uc001fli.2_Silent_p.V703V|YY1AP1_uc009wqu.2_Silent_p.V536V|YY1AP1_uc001flj.2_Silent_p.V683V|YY1AP1_uc009wqw.2_Silent_p.V672V|YY1AP1_uc001flo.2_Silent_p.V637V|YY1AP1_uc001flp.2_Silent_p.V703V	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	749					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CCTCTGTTTTCACAACGGTCC	0.527													0	0	0	0.144211	0	30	106										T	155629592	C	T	155629592	2	4	45	1	0	0	0	0	0	0	0	1	17505	813	29	1		1	YY1AP1	1	155629592	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	7	155629592	93621029	13	11476	52	2								
TMEM79	84283	broad.mit.edu	37	chr1	156261349	156261349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cctggactacccggaccacgCccgctcggcctccgactaca	9	20	0	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:156261349C>T	uc010phi.1	+	4	1341	c.1145C>T	c.(1144-1146)GCC>GTC	p.A382V	TMEM79_uc001fod.2_Missense_Mutation_p.A223V|TMEM79_uc009wrw.2_Missense_Mutation_p.A382V|C1orf85_uc001fof.3_Intron|C1orf85_uc001fog.1_Intron	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	382						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					CCGGACCACGCCCGCTCGGCC	0.657													0	0	0	0.043863	0	7	37										T	156261349	C	T	156261349	3	4	45	1	0	0	0	0	1	0	0	0	16200	739	26	2	1155	2	TMEM79	1	156261349	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	631757	156261349	92989272	14	11477										
ARHGEF11	9826	broad.mit.edu	37	chr1	156948001	156948001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	caggaggattattacctgcaGaggtttgggtcctgtgatgc	14	7	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:156948001G>C	uc001fqo.2	-	6	1545	c.505C>G	c.(505-507)CTG>GTG	p.L169V	ARHGEF11_uc001fqn.2_Missense_Mutation_p.L169V	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	169					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ATTACCTGCAGAGGTTTGGGT	0.552													0	0	0	0.11911	0	13	30										C	156948001	G	C	156948001	3	2	45	1	0	0	0	0	1	0	0	0	896	933	33	1	4327	1	ARHGEF11	1	156948001	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	686652	156948001	92302620	15	11478										
OR10X1	128367	broad.mit.edu	37	chr1	158549553	158549553	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gaaggtagagacaaaagaagAccacaaaaagaaatgtctgt	10	5	1	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:158549553A>G	uc010pin.1	-	1	137	c.137T>C	c.(136-138)GTC>GCC	p.V46A		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ACAAAAGAAGACCACAAAAAG	0.433													0	0	0	0.11126	0	37	108										G	158549553	A	G	158549553	3	3	45	1	0	0	0	0	1	0	0	0	10922	275	10	5	838	5	OR10X1	1	158549553	Missense_Mutation	SNP	A	TCGA-DK-A1AB-01A-11D-A13W-08	1601552	158549553	90701068	16	11479										
PPOX	5498	broad.mit.edu	37	chr1	161138959	161138959	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgggctcagcctccaggcaGaagggcgctggaaggtaggg	19	9	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:161138959G>C	uc001fyj.2	+	7	1083	c.793G>C	c.(793-795)GAA>CAA	p.E265Q	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Missense_Mutation_p.E265Q|PPOX_uc001fyl.2_Missense_Mutation_p.E231Q|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Missense_Mutation_p.E103Q|PPOX_uc001fyh.2_Missense_Mutation_p.E103Q|PPOX_uc010pkg.1_Missense_Mutation_p.E103Q|PPOX_uc009wuc.1_Missense_Mutation_p.E103Q|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Missense_Mutation_p.E103Q	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	265					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCTCCAGGCAGAAGGGCGCTG	0.567									Porphyria_Variegata				0	0	0	0.038395	0	16	41										C	161138959	G	C	161138959	3	2	45	1	0	0	0	0	1	0	0	0	12348	943	33	1	815	1	PPOX	1	161138959	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2589406	161138959	88111662	17	11480										
DCAF6	55827	broad.mit.edu	37	chr1	168014277	168014277	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gaaccagaaacttcagatcaGactagcactgagagtgctac	9	10	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:168014277G>A	uc001gew.2	+	14	2081	c.1839G>A	c.(1837-1839)CAG>CAA	p.Q613Q	DCAF6_uc001gev.2_Silent_p.Q633Q|DCAF6_uc001gex.2_Silent_p.Q690Q|DCAF6_uc010plk.1_Silent_p.Q659Q|DCAF6_uc001gey.2_Silent_p.Q486Q|DCAF6_uc001gez.2_5'UTR	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	613					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTTCAGATCAGACTAGCACTG	0.453													0	0	0	0.069456	0	37	90										A	168014277	G	A	168014277	2	1	45	1	0	0	0	0	0	0	0	1	4274	933	33	1		1	DCAF6	1	168014277	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6875318	168014277	81236344	18	11481										
SCYL3	57147	broad.mit.edu	37	chr1	169839492	169839492	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctctgggagagttgtgaattCtggagactaaaagcagtgaa	13	5	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:169839492C>G	uc001ggs.2	-	6	727	c.529G>C	c.(529-531)GAA>CAA	p.E177Q	SCYL3_uc010plw.1_5'UTR|SCYL3_uc001ggt.2_Missense_Mutation_p.E177Q|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	177	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTTGTGAATTCTGGAGACTAA	0.398													0	0	0	0.0918	0	24	69										G	169839492	C	G	169839492	3	3	45	1	0	0	0	0	1	0	0	0	13949	922	32	1	1735	1	SCYL3	1	169839492	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1825215	169839492	79411129	19	11482										
C1orf25	81627	broad.mit.edu	37	chr1	185112497	185112497	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtcctcacttaccagtggctCcaaaagcatctagacattcc	6	14	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:185112497C>G	uc001grf.3	-	7	1123	c.851G>C	c.(850-852)GGA>GCA	p.G284A	C1orf25_uc010pon.1_Missense_Mutation_p.G128A	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	284						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						ACCAGTGGCTCCAAAAGCATC	0.338													0	0	0	0.050027	0	29	122										G	185112497	C	G	185112497	3	3	45	1	0	0	0	0	1	0	0	0	2034	855	30	1	1386	1	C1orf25	1	185112497	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	15273005	185112497	64138124	20	11483										
RPS6KC1	26750	broad.mit.edu	37	chr1	213303065	213303065	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agaagaagaacgggaaagtcGtagcctctttcctggcagtt	12	8	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:213303065G>A	uc010ptr.1	+	6	827	c.668G>A	c.(667-669)CGT>CAT	p.R223H	RPS6KC1_uc001hkd.2_Missense_Mutation_p.R211H|RPS6KC1_uc010pts.1_Missense_Mutation_p.R42H|RPS6KC1_uc010ptt.1_Missense_Mutation_p.R42H|RPS6KC1_uc010ptu.1_Missense_Mutation_p.R42H|RPS6KC1_uc010ptv.1_5'UTR|RPS6KC1_uc001hke.2_Missense_Mutation_p.R42H	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	223					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CGGGAAAGTCGTAGCCTCTTT	0.413													0	0	0	0.045705	0	30	74										A	213303065	G	A	213303065	3	1	45	1	0	0	0	0	1	0	0	0	13658	1145	40	2	690	2	RPS6KC1	1	213303065	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	28190568	213303065	35947556	21	11484										
SPATA17	128153	broad.mit.edu	37	chr1	217975148	217975148	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atggtcctatttcttacaaaGaacaattccgaagtgaaaat	6	7	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:217975148G>C	uc001hlh.1	+	9	987	c.961G>C	c.(961-963)GAA>CAA	p.E321Q	SPATA17_uc001hli.2_Missense_Mutation_p.E321Q	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	321						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TTCTTACAAAGAACAATTCCG	0.294													0	0	0	0.09319	0	13	51										C	217975148	G	C	217975148	3	2	45	1	0	0	0	0	1	0	0	0	15001	943	33	1	995	1	SPATA17	1	217975148	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	4672083	217975148	31275473	22	11485										
URB2	9816	broad.mit.edu	37	chr1	229773838	229773838	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tctaccagggtgtttactctCagatactgttggagttgcca	10	9	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:229773838C>T	uc001hts.1	+	4	3614	c.3478C>T	c.(3478-3480)CAG>TAG	p.Q1160*	URB2_uc009xfd.1_Nonsense_Mutation_p.Q1160*	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1160						nucleolus				central_nervous_system(2)|ovary(1)	3						TGTTTACTCTCAGATACTGTT	0.552													0	0	0	0.134883	0	30	61										T	229773838	C	T	229773838	4	4	45	1	0	0	0	0	0	1	0	0	17022	827	29	1	3488	1	URB2	1	229773838	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	11798690	229773838	19476783	23	11486										
URB2	9816	broad.mit.edu	37	chr1	229773864	229773864	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgttggagttgccagctctCgcgggacatgatcagtcttt	12	10	3	1	rs114023508	byFrequency	TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:229773864C>T	uc001hts.1	+	4	3640	c.3504C>T	c.(3502-3504)CTC>CTT	p.L1168L	URB2_uc009xfd.1_Silent_p.L1168L	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1168						nucleolus				central_nervous_system(2)|ovary(1)	3						TGCCAGCTCTCGCGGGACATG	0.527													0	0	0	0.064281	0	35	64										T	229773864	C	T	229773864	2	4	45	1	0	0	0	0	0	0	0	1	17022	871	31	1		1	URB2	1	229773864	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	26	229773864	19476757	24	11487										
COG2	22796	broad.mit.edu	37	chr1	230810788	230810788	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atatgactttttggtgaattCtgtttggccacaaatagtac	8	6	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:230810788C>T	uc001htw.2	+	9	1095	c.944C>T	c.(943-945)TCT>TTT	p.S315F	COG2_uc001htx.2_Missense_Mutation_p.S315F|COG2_uc010pwc.1_Missense_Mutation_p.S188F	NM_007357	NP_031383	Q14746	COG2_HUMAN	component of oligomeric golgi complex 2 isoform	315					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TTGGTGAATTCTGTTTGGCCA	0.393													0	0	0	0.11126	0	43	134										T	230810788	C	T	230810788	3	4	45	1	0	0	0	0	1	0	0	0	3658	913	32	1	978	1	COG2	1	230810788	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1036924	230810788	18439833	25	11488										
PCNXL2	80003	broad.mit.edu	37	chr1	233394101	233394101	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttccttccccaccttagactCggagcctgtatcaggtgtaa	8	13	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:233394101C>T	uc001hvl.2	-	5	1742	c.1507G>A	c.(1507-1509)GAG>AAG	p.E503K	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	503						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ACCTTAGACTCGGAGCCTGTA	0.562													0	0	0	0.043863	0	18	57										T	233394101	C	T	233394101	3	4	45	1	0	0	0	0	1	0	0	0	11592	893	31	1	5026	1	PCNXL2	1	233394101	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	2583313	233394101	15856520	26	11489										
EXO1	9156	broad.mit.edu	37	chr1	242048726	242048726	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aagaagccggcaagcatccaGaagagaaagcatcataatgc	10	9	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:242048726G>A	uc001hzh.2	+	15	2862	c.2322G>A	c.(2320-2322)CAG>CAA	p.Q774Q	EXO1_uc001hzi.2_Silent_p.Q774Q|EXO1_uc001hzj.2_Silent_p.Q774Q|EXO1_uc009xgq.2_Silent_p.Q773Q	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	774	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			CAAGCATCCAGAAGAGAAAGC	0.453								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.049695	0	19	53										A	242048726	G	A	242048726	2	1	45	1	0	0	0	0	0	0	0	1	5300	933	33	1		1	EXO1	1	242048726	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	8654625	242048726	7201895	27	11490										
OR2T6	254879	broad.mit.edu	37	chr1	248551413	248551413	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	attaccatgagtctcccgttCtgtgcctctcaccaaatcaa	5	14	4	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr1:248551413C>G	uc001iei.1	+	1	504	c.504C>G	c.(502-504)TTC>TTG	p.F168L		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTCTCCCGTTCTGTGCCTCTC	0.532													0	0	0	0.09319	0	13	35										G	248551413	C	G	248551413	3	3	45	1	0	0	0	0	1	0	0	0	11029	912	32	1	506	1	OR2T6	1	248551413	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	6502687	248551413	699208	28	11491										
NTSR2	23620	broad.mit.edu	37	chr2	11798719	11798719	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgctctccacacagggagctGacggcttccaggaagagttt	12	11	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:11798719G>A	uc002rbq.3	-	4	1193	c.1119C>T	c.(1117-1119)GTC>GTT	p.V373V		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	373	Cytoplasmic (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	ACAGGGAGCTGACGGCTTCCA	0.562													0	0	0	0.083992	0	21	66										A	11798719	G	A	11798719	2	1	45	1	0	0	0	0	0	0	0	1	10711	1277	45	1		1	NTSR2	2	11798719	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		11798719	231400654	29	11492										
APOB	338	broad.mit.edu	37	chr2	21233133	21233133	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taatttttcaatgatttcatCaataatattagcaatagcta	3	5	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:21233133C>G	uc002red.2	-	26	6735	c.6607G>C	c.(6607-6609)GAT>CAT	p.D2203H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2203					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGATTTCATCAATAATATTA	0.239													0	0	0	0.076483	0	24	56										G	21233133	C	G	21233133	3	3	45	1	0	0	0	0	1	0	0	0	785	826	29	1	7100	1	APOB	2	21233133	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	9434414	21233133	221966240	30	11493										
CAD	790	broad.mit.edu	37	chr2	27460592	27460592	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgtatcctctccagctggcaGaggctggcgcccggtgcgac	14	14	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:27460592G>A	uc002rji.2	+	29	4732	c.4570G>A	c.(4570-4572)GAG>AAG	p.E1524K	CAD_uc010eyw.2_Missense_Mutation_p.E1461K	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1524	DHOase (dihydroorotase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CCAGCTGGCAGAGGCTGGCGC	0.647													0	0	0	0.09319	0	12	32										A	27460592	G	A	27460592	3	1	45	1	0	0	0	0	1	0	0	0	2565	943	33	1	4684	1	CAD	2	27460592	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6227459	27460592	215738781	31	11494										
SRBD1	55133	broad.mit.edu	37	chr2	45826690	45826690	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tatgtctcagtcttgattttCtttaaagcggactgaccaaa	7	8	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:45826690C>G	uc002rus.2	-	4	622	c.546G>C	c.(544-546)AAG>AAC	p.K182N		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	182					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TCTTGATTTTCTTTAAAGCGG	0.443													0	0	0	0.139131	0	56	254										G	45826690	C	G	45826690	3	3	45	1	0	0	0	0	1	0	0	0	15132	912	32	1	2513	1	SRBD1	2	45826690	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	18366098	45826690	197372683	32	11495										
FSHR	2492	broad.mit.edu	37	chr2	49244635	49244635	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	catgagttcttacagatattGaaggttgggaaggttctgga	13	4	2	3	rs138079934	byFrequency	TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:49244635G>A	uc002rww.2	-	4	441	c.367C>T	c.(367-369)CAA>TAA	p.Q123*	FSHR_uc002rwx.2_Nonsense_Mutation_p.Q123*|FSHR_uc010fbn.2_Nonsense_Mutation_p.Q123*|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	123	Extracellular (Potential).|LRR 4.				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TACAGATATTGAAGGTTGGGA	0.398									Gonadal_Dysgenesis_46_XX				0	0	0	0.105934	0	14	52										A	49244635	G	A	49244635	4	1	45	1	0	0	0	0	0	1	0	0	6073	1299	45	1	1748	1	FSHR	2	49244635	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3417945	49244635	193954738	33	11496										
SPTBN1	6711	broad.mit.edu	37	chr2	54874297	54874297	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agtgctgtctccatgttgaaGaagcaccagatcttagaaca	9	9	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:54874297G>A	uc002rxu.2	+	24	5145	c.4896G>A	c.(4894-4896)AAG>AAA	p.K1632K	SPTBN1_uc002rxx.2_Silent_p.K1619K	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1632	Interaction with ANK2.|Spectrin 13.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CCATGTTGAAGAAGCACCAGA	0.552													0	0	0	0.0918	0	25	89										A	54874297	G	A	54874297	2	1	45	1	0	0	0	0	0	0	0	1	15118	933	33	1		1	SPTBN1	2	54874297	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	5629662	54874297	188325076	34	11497										
LOXL3	84695	broad.mit.edu	37	chr2	74779555	74779555	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcgtgaagtcatcatcgcaGatggtgccccattcaccagc	10	13	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:74779555G>A	uc002smp.1	-	2	279	c.207C>T	c.(205-207)ATC>ATT	p.I69I	LOXL3_uc002smo.1_5'Flank|LOXL3_uc010ffm.1_Silent_p.I69I|LOXL3_uc002smq.1_Silent_p.I69I|LOXL3_uc010ffn.1_Silent_p.I69I|DOK1_uc002smr.2_Intron|DOK1_uc002sms.2_5'Flank|DOK1_uc010ffo.2_5'Flank|DOK1_uc002smt.2_5'Flank|DOK1_uc002smu.2_5'Flank|DOK1_uc010yrz.1_5'Flank|DOK1_uc002smv.2_5'Flank|DOK1_uc002smw.1_5'Flank	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	69	SRCR 1.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CATCATCGCAGATGGTGCCCC	0.652													0	0	0	0.069288	0	21	46										A	74779555	G	A	74779555	2	1	45	1	0	0	0	0	0	0	0	1	8901	932	33	1		1	LOXL3	2	74779555	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	19905258	74779555	168419818	35	11498										
LMAN2L	81562	broad.mit.edu	37	chr2	97373526	97373526	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttcctcttctggggttctctCcactgtcagttcaaacaact	6	13	5	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:97373526C>G	uc002swu.2	-	7	865	c.829G>C	c.(829-831)GAG>CAG	p.E277Q	LMAN2L_uc002swv.2_Missense_Mutation_p.E288Q|LMAN2L_uc010yut.1_Missense_Mutation_p.E143Q|LMAN2L_uc010yuu.1_Missense_Mutation_p.E141Q|LMAN2L_uc010yuv.1_Missense_Mutation_p.E130Q|LMAN2L_uc010yuw.1_Missense_Mutation_p.E132Q|LMAN2L_uc002sww.2_Missense_Mutation_p.E130Q|LMAN2L_uc010yux.1_Missense_Mutation_p.E132Q	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	277	Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						GGGGTTCTCTCCACTGTCAGT	0.453													0	0	0	0.086207	0	40	109										G	97373526	C	G	97373526	3	3	45	1	0	0	0	0	1	0	0	0	8839	864	30	1	225	1	LMAN2L	2	97373526	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	22593971	97373526	145825847	36	11499										
RGPD4	285190	broad.mit.edu	37	chr2	108488568	108488568	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aactctacagatatgataaaGatgttggtcaatggaaagaa	9	4	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:108488568G>C	uc010ywk.1	+	20	4190	c.4108G>C	c.(4108-4110)GAT>CAT	p.D1370H	RGPD4_uc002tdu.2_Missense_Mutation_p.D557H|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1370	RanBD1 2.				intracellular transport		binding			skin(2)	2						ATATGATAAAGATGTTGGTCA	0.358													0	0	0	0.02938	0	6	373										C	108488568	G	C	108488568	3	2	45	1	0	0	0	0	1	0	0	0	13288	942	33	1	4186	1	RGPD4	2	108488568	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	11115042	108488568	134710805	37	11500										
GCC2	9648	broad.mit.edu	37	chr2	109100719	109100719	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agatagaagatttggagcaaGaaataaaaattcaaaaacag	8	3	1	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:109100719G>A	uc002tec.2	+	13	3719	c.3565G>A	c.(3565-3567)GAA>AAA	p.E1189K	GCC2_uc002ted.2_Missense_Mutation_p.E1088K	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1189	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						TTTGGAGCAAGAAATAAAAAT	0.254													0	0	0	0.049695	0	21	50										A	109100719	G	A	109100719	3	1	45	1	0	0	0	0	1	0	0	0	6286	943	33	1	3615	1	GCC2	2	109100719	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	612151	109100719	134098654	38	11501										
DDX18	8886	broad.mit.edu	37	chr2	118582552	118582552	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cttctgaaaagagattccttCtgctctttacattccttaag	5	10	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:118582552C>T	uc002tlh.1	+	9	1342	c.1243C>T	c.(1243-1245)CTG>TTG	p.L415L		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	415	Helicase C-terminal.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						GAGATTCCTTCTGCTCTTTAC	0.368													0	0	0	0.074837	0	40	138										T	118582552	C	T	118582552	2	4	45	1	0	0	0	0	0	0	0	1	4345	912	32	1		1	DDX18	2	118582552	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	9481833	118582552	124616821	39	11502										
TMEM37	140738	broad.mit.edu	37	chr2	120194518	120194518	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cggtccttctttgaatccttCatccggaccctcatcatcac	5	16	5	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:120194518C>T	uc002tly.2	+	2	109	c.75C>T	c.(73-75)TTC>TTT	p.F25F		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	25	Helical; (Potential).					integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						TTGAATCCTTCATCCGGACCC	0.617													0	0	0	0.064281	0	37	57										T	120194518	C	T	120194518	2	4	45	1	0	0	0	0	0	0	0	1	16155	825	29	1		1	TMEM37	2	120194518	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1611966	120194518	123004855	40	11503										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135883809	135883809	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aagggatcattgtggataatGatgtttattcgtaagtatgt	11	2	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:135883809G>A	uc002tuj.2	+	10	914	c.889G>A	c.(889-891)GAT>AAT	p.D297N	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.D297N|RAB3GAP1_uc010fng.2_Missense_Mutation_p.D122N|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	297						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TGTGGATAATGATGTTTATTC	0.308													0	0	0	0.116897	0	28	86										A	135883809	G	A	135883809	3	1	45	1	0	0	0	0	1	0	0	0	12935	1290	45	1	927	1	RAB3GAP1	2	135883809	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	15689291	135883809	107315564	41	11504										
NEB	4703	broad.mit.edu	37	chr2	152349881	152349881	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aaataccgagctaatgttttCttggttgcgcttagctctct	8	9	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:152349881C>T	uc010fnx.2	-	143	19374	c.19183G>A	c.(19183-19185)GAA>AAA	p.E6395K	NEB_uc002txr.2_Intron|RIF1_uc002txp.2_Intron|NEB_uc010zbz.1_Missense_Mutation_p.E164K|NEB_uc002txq.2_Missense_Mutation_p.E274K|NEB_uc010zca.1_Missense_Mutation_p.E226K|NEB_uc010zcb.1_Missense_Mutation_p.E164K	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6395	Nebulin 176.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTAATGTTTTCTTGGTTGCGC	0.383													0	0	0	0.132662	0	14	40										T	152349881	C	T	152349881	3	4	45	1	0	0	0	0	1	0	0	0	10302	922	32	1	854	1	NEB	2	152349881	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	16466072	152349881	90849492	42	11505										
NOSTRIN	115677	broad.mit.edu	37	chr2	169717349	169717349	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atatctcggccttttttaatGaagagattagagaatattgt	8	4	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:169717349G>A	uc002ueg.2	+	14	1228	c.1224G>A	c.(1222-1224)ATG>ATA	p.M408I	NOSTRIN_uc002uef.2_Missense_Mutation_p.M465I|NOSTRIN_uc002uei.2_Missense_Mutation_p.M291I|NOSTRIN_uc010fpu.2_Missense_Mutation_p.M380I|NOSTRIN_uc002ueh.2_Missense_Mutation_p.M330I|NOSTRIN_uc002uej.2_Missense_Mutation_p.M291I|NOSTRIN_uc002uek.2_Missense_Mutation_p.M92I	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	408					endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						CTTTTTTAATGAAGAGATTAG	0.378													0	0	0	0.108266	0	26	75										A	169717349	G	A	169717349	3	1	45	1	0	0	0	0	1	0	0	0	10546	1290	45	1	1453	1	NOSTRIN	2	169717349	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	17367468	169717349	73482024	43	11506										
TTN	7273	broad.mit.edu	37	chr2	179440567	179440567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggcctggcgtgtccaagactCtgacgttcacaaagccactt	10	13	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:179440567C>G	uc010zfg.1	-	275	62812	c.62588G>C	c.(62587-62589)AGA>ACA	p.R20863T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R14558T|TTN_uc010zfi.1_Missense_Mutation_p.R14491T|TTN_uc010zfj.1_Missense_Mutation_p.R14366T|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21790							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCAAGACTCTGACGTTCAC	0.502													0	0	0	0.139131	0	48	131										G	179440567	C	G	179440567	3	3	45	1	0	0	0	0	1	0	0	0	16732	913	32	1	37835	1	TTN	2	179440567	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	9723218	179440567	63758806	44	11507										
TTN	7273	broad.mit.edu	37	chr2	179481949	179481949	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taaatatttatttcctttttCcaatccggtaacctacgatt	3	9	0	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:179481949C>A	uc010zfg.1	-	204	40293	c.40069G>T	c.(40069-40071)GAA>TAA	p.E13357*	TTN_uc010zfh.1_Nonsense_Mutation_p.E7052*|TTN_uc010zfi.1_Nonsense_Mutation_p.E6985*|TTN_uc010zfj.1_Nonsense_Mutation_p.E6860*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14284							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCCTTTTTCCAATCCGGTA	0.323													1	0	0.004672	0.115264	0.005088	3	6										A	179481949	C	A	179481949	4	1	45	1	0	0	0	0	0	1	0	0	16732	864	30	3	60352	3	TTN	2	179481949	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	41382	179481949	63717424	45	11508										
TTN	7273	broad.mit.edu	37	chr2	179604510	179604510	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agctgttaggatgtctatttCctcatatataatagcacaca	6	8	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:179604510C>T	uc010zfh.1	-	46	13161	c.12937G>A	c.(12937-12939)GAA>AAA	p.E4313K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4246K|TTN_uc010zfj.1_Missense_Mutation_p.E4121K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTCTATTTCCTCATATATA	0.378													0	0	0	0.139131	0	62	282										T	179604510	C	T	179604510	3	4	45	1	0	0	0	0	1	0	0	0	16732	864	30	1	91339	1	TTN	2	179604510	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	122561	179604510	63594863	46	11509										
TTN	7273	broad.mit.edu	37	chr2	179605584	179605584	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aagaaattccctggtgctttCaggagtgagcttgtcttgct	11	8	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:179605584C>T	uc010zfh.1	-	46	12087	c.11863G>A	c.(11863-11865)GAA>AAA	p.E3955K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E3888K|TTN_uc010zfj.1_Missense_Mutation_p.E3763K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3883							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTGCTTTCAGGAGTGAGC	0.448													0	0	0	0.086207	0	38	146										T	179605584	C	T	179605584	3	4	45	1	0	0	0	0	1	0	0	0	16732	835	29	1	92413	1	TTN	2	179605584	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1074	179605584	63593789	47	11510										
DNAH7	56171	broad.mit.edu	37	chr2	196636429	196636429	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cacgaatctcttatggtcttCagtaacttattgaaccgtcc	6	11	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:196636429C>T	uc002utj.3	-	61	11489	c.11388G>A	c.(11386-11388)CTG>CTA	p.L3796L	DNAH7_uc002uti.3_Silent_p.L279L	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3796					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTATGGTCTTCAGTAACTTAT	0.378													0	0	0	0.139131	0	71	177										T	196636429	C	T	196636429	2	4	45	1	0	0	0	0	0	0	0	1	4606	813	29	1		1	DNAH7	2	196636429	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	17030845	196636429	46562944	48	11511										
SGOL2	151246	broad.mit.edu	37	chr2	201437629	201437629	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aggataaagaaacaatttctGaaaatctacaagtcacaaat	5	6	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:201437629G>C	uc002uvw.2	+	7	2673	c.2560G>C	c.(2560-2562)GAA>CAA	p.E854Q	SGOL2_uc010zhd.1_Missense_Mutation_p.E854Q|SGOL2_uc010zhe.1_Missense_Mutation_p.E854Q	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	854					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AACAATTTCTGAAAATCTACA	0.308													0	0	0	0.139131	0	48	144										C	201437629	G	C	201437629	3	2	45	1	0	0	0	0	1	0	0	0	14217	1291	45	1	2582	1	SGOL2	2	201437629	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	4801200	201437629	41761744	49	11512										
INO80D	54891	broad.mit.edu	37	chr2	206884568	206884568	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cctcagcttggtccggcttaTgctaaggaaagaaaaacaga	10	9	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:206884568T>A	uc002vaz.3	-	7	1705	c.1300A>T	c.(1300-1302)ATA>TTA	p.I434L		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	434					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GTCCGGCTTATGCTAAGGAAA	0.418													0	0	0	0.02938	0	7	36										A	206884568	T	A	206884568	3	1	45	1	0	0	0	0	1	0	0	0	7749	1478	51	5	1803	5	INO80D	2	206884568	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08	5446939	206884568	36314805	50	11513										
NDUFS1	4719	broad.mit.edu	37	chr2	207009718	207009718	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taaccacaatattacttccaAccgcatccattacatcaatg	2	13	1	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:207009718A>C	uc002vbe.2	-	9	897	c.770T>G	c.(769-771)GTT>GGT	p.V257G	NDUFS1_uc010ziq.1_Missense_Mutation_p.V271G|NDUFS1_uc010zir.1_Missense_Mutation_p.V221G|NDUFS1_uc010zis.1_Missense_Mutation_p.V200G|NDUFS1_uc010zit.1_Missense_Mutation_p.V146G|NDUFS1_uc010ziu.1_Missense_Mutation_p.V141G	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	257					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	ATTACTTCCAACCGCATCCAT	0.393													0	0	0	0.049695	0	20	77										C	207009718	A	C	207009718	3	2	45	1	0	0	0	0	1	0	0	0	10291	43	2	5	1457	5	NDUFS1	2	207009718	Missense_Mutation	SNP	A	TCGA-DK-A1AB-01A-11D-A13W-08	125150	207009718	36189655	51	11514										
DNPEP	23549	broad.mit.edu	37	chr2	220246839	220246839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgtcagcagtgactgtgctCcctgtgcactctcagacccc	9	16	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:220246839C>T	uc010zlg.1	-	11	1065	c.983G>A	c.(982-984)GGA>GAA	p.G328E	DNPEP_uc010zlf.1_RNA|DNPEP_uc002vle.2_Missense_Mutation_p.G320E|DNPEP_uc002vlf.1_Missense_Mutation_p.G306E|DNPEP_uc002vlh.2_Missense_Mutation_p.G267E|DNPEP_uc002vli.1_Missense_Mutation_p.G267E	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	310					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	TGACTGTGCTCCCTGTGCACT	0.602													0	0	0	0.021553	0	6	20										T	220246839	C	T	220246839	3	4	45	1	0	0	0	0	1	0	0	0	4679	855	30	1	518	1	DNPEP	2	220246839	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	13237121	220246839	22952534	52	11515										
SH3BP4	23677	broad.mit.edu	37	chr2	235943740	235943740	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acctgagcgaagggttttcaGagacgagctttaatgacatc	11	8	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:235943740G>A	uc002vvp.2	+	3	487	c.94G>A	c.(94-96)GAG>AAG	p.E32K	SH3BP4_uc010fym.2_Missense_Mutation_p.E32K|SH3BP4_uc002vvq.2_Missense_Mutation_p.E32K	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	32					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AGGGTTTTCAGAGACGAGCTT	0.532													0	0	0	0.038147	0	8	36										A	235943740	G	A	235943740	3	1	45	1	0	0	0	0	1	0	0	0	14246	943	33	1	96	1	SH3BP4	2	235943740	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	15696901	235943740	7255633	53	11516										
COL6A3	1293	broad.mit.edu	37	chr2	238277324	238277324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tctctgaactctcgcactgtGaagaccagtctggggtcatt	10	11	4	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr2:238277324G>C	uc002vwl.2	-	10	5067	c.4782C>G	c.(4780-4782)TTC>TTG	p.F1594L	COL6A3_uc002vwo.2_Missense_Mutation_p.F1388L|COL6A3_uc010znj.1_Missense_Mutation_p.F987L	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1594	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTCGCACTGTGAAGACCAGTC	0.547													0	0	0	0.059317	0	33	229										C	238277324	G	C	238277324	3	2	45	1	0	0	0	0	1	0	0	0	3701	1281	45	1	4891	1	COL6A3	2	238277324	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2333584	238277324	4922049	54	11517										
CAND2	23066	broad.mit.edu	37	chr3	12858016	12858016	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcctgccacctgtgatggccTgtgtggctgactctttctac	10	13	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:12858016T>A	uc003bxk.2	+	10	1634	c.1585T>A	c.(1585-1587)TGT>AGT	p.C529S	CAND2_uc003bxj.2_Missense_Mutation_p.C436S	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	529	HEAT 11.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						TGTGATGGCCTGTGTGGCTGA	0.647													0	0	0	0.115264	0	3	37										A	12858016	T	A	12858016	3	1	45	1	0	0	0	0	1	0	0	0	2616	1580	55	5	1623	5	CAND2	3	12858016	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08		12858016	185164414	55	11518										
TBC1D5	9779	broad.mit.edu	37	chr3	17349598	17349598	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aaggtcctgcagggggaactCtcgtccaaatagcagccgca	12	12	1	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:17349598C>T	uc003cbf.2	-	14	2689	c.1024G>A	c.(1024-1026)GAG>AAG	p.E342K	TBC1D5_uc010heu.2_5'UTR|TBC1D5_uc010hev.2_Missense_Mutation_p.E342K|TBC1D5_uc003cbe.2_Missense_Mutation_p.E342K|TBC1D5_uc010hew.1_Missense_Mutation_p.E294K	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	342	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						AGGGGGAACTCTCGTCCAAAT	0.438													0	0	0	0.11911	0	11	14										T	17349598	C	T	17349598	3	4	45	1	0	0	0	0	1	0	0	0	15620	922	32	1	1469	1	TBC1D5	3	17349598	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4491582	17349598	180672832	56	11519										
CCDC12	151903	broad.mit.edu	37	chr3	46963564	46963564	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gcctcagtcggagtcacaggTcttttgttcggtggcagcat	13	10	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:46963564T>G	uc003cqo.2	-	7	532	c.523A>C	c.(523-525)ACC>CCC	p.T175P		NM_144716	NP_653317	Q8WUD4	CCD12_HUMAN	coiled-coil domain containing 12	162											0		Prostate(884;0.0143)|Ovarian(412;0.0448)|Acute lymphoblastic leukemia(5;0.143)		OV - Ovarian serous cystadenocarcinoma(275;2.2e-56)|BRCA - Breast invasive adenocarcinoma(193;0.00136)|KIRC - Kidney renal clear cell carcinoma(197;0.00703)|Kidney(197;0.00809)		GAGTCACAGGTCTTTTGTTCG	0.617													0	0	0	0.014758	0	4	14										G	46963564	T	G	46963564	3	3	45	1	0	0	0	0	1	0	0	0	2755	1667	58	5	20	5	CCDC12	3	46963564	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08	29613966	46963564	151058866	57	11520										
SETD2	29072	broad.mit.edu	37	chr3	47142947	47142947	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	attagtagaaacaatacttaCccatatctctggaactgata	5	8	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:47142947C>T	uc003cqs.2	-	8	5068	c.5015_splice	c.e8+1	p.G1672_splice	SETD2_uc003cqv.2_Splice_Site_p.G1739_splice	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ACAATACTTACCCATATCTCT	0.358			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.09836	0	39	89										T	47142947	C	T	47142947	5	4	45	1	0	0	0	0	0	0	1	0	14131	521	18	2	2734	2	SETD2	3	47142947	Splice_Site	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	179383	47142947	150879483	58	11521										
PTPRG	5793	broad.mit.edu	37	chr3	62261595	62261595	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtggaatgtttcagtgctcaGaaagagtgtaacaaagaaaa	11	4	2	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:62261595G>A	uc003dlb.2	+	24	4232	c.3513G>A	c.(3511-3513)CAG>CAA	p.Q1171Q	PTPRG_uc003dlc.2_Silent_p.Q1142Q|PTPRG_uc011bfi.1_Silent_p.Q417Q|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1171	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TCAGTGCTCAGAAAGAGTGTA	0.318													0	0	0	0.069288	0	20	27										A	62261595	G	A	62261595	2	1	45	1	0	0	0	0	0	0	0	1	12802	933	33	1		1	PTPRG	3	62261595	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	15118648	62261595	135760835	59	11522										
PPP4R2	151987	broad.mit.edu	37	chr3	73114035	73114035	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctctgaatcagaagtttcctCagtgagccctttgaaaaata	7	9	3	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:73114035C>G	uc003dph.1	+	8	741	c.671C>G	c.(670-672)TCA>TGA	p.S224*	PPP4R2_uc003dpi.1_Nonsense_Mutation_p.S167*	NM_174907	NP_777567	Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	224					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			lung(1)	1		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		GAAGTTTCCTCAGTGAGCCCT	0.378													0	0	0	0.083992	0	25	58										G	73114035	C	G	73114035	4	3	45	1	0	0	0	0	0	1	0	0	12404	838	29	1	701	1	PPP4R2	3	73114035	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	10852440	73114035	124908395	60	11523										
PPP4R2	151987	broad.mit.edu	37	chr3	73114241	73114241	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acaaagatagccgttgtaccCggcagcactgtacagaagag	11	10	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:73114241C>A	uc003dph.1	+	8	947	c.877C>A	c.(877-879)CGG>AGG	p.R293R	PPP4R2_uc003dpi.1_Silent_p.R236R	NM_174907	NP_777567	Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	293					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			lung(1)	1		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		CCGTTGTACCCGGCAGCACTG	0.348													1	0	0.004672	0.115264	0.005088	3	34										A	73114241	C	A	73114241	2	1	45	1	0	0	0	0	0	0	0	1	12404	643	23	4		4	PPP4R2	3	73114241	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	206	73114241	124908189	61	11524										
C3orf52	79669	broad.mit.edu	37	chr3	111821711	111821711	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atgttgatgaagatgaaaatGaaatacttgaattatcatca	7	3	2	6	rs139531193	by1000genomes	TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:111821711G>C	uc003dyq.3	+	3	368	c.295G>C	c.(295-297)GAA>CAA	p.E99Q	C3orf52_uc011bhs.1_Missense_Mutation_p.E99Q|C3orf52_uc011bht.1_Missense_Mutation_p.E99Q	NM_024616	NP_078892	Q5BVD1	TTMP_HUMAN	TPA-induced transmembrane protein	99						endoplasmic reticulum membrane|integral to membrane					0						AGATGAAAATGAAATACTTGA	0.343													0	0	0	0.115264	0	2	5										C	111821711	G	C	111821711	3	2	45	1	0	0	0	0	1	0	0	0	2232	1291	45	1	305	1	C3orf52	3	111821711	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	38707470	111821711	86200719	62	11525										
SLC9A10	285335	broad.mit.edu	37	chr3	111996650	111996650	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taattgatttacagatgccaGatgccaaagaactaagatat	7	6	0	5			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:111996650G>C	uc003dyu.2	-	5	598	c.376C>G	c.(376-378)CTG>GTG	p.L126V	SLC9A10_uc011bhu.1_Translation_Start_Site|SLC9A10_uc010hqc.2_Missense_Mutation_p.L126V	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	126					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ACAGATGCCAGATGCCAAAGA	0.343													0	0	0	0.125774	0	29	95										C	111996650	G	C	111996650	3	2	45	1	0	0	0	0	1	0	0	0	14710	933	33	1	3257	1	SLC9A10	3	111996650	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	174939	111996650	86025780	63	11526										
HEG1	57493	broad.mit.edu	37	chr3	124746337	124746337	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgaactgctggatggcaggtGaagactttctgaggctgaaa	14	6	1	5			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:124746337G>A	uc003ehs.3	-	3	693	c.625C>T	c.(625-627)CAC>TAC	p.H209Y	HEG1_uc011bke.1_Missense_Mutation_p.H209Y	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	209	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GATGGCAGGTGAAGACTTTCT	0.453													0	0	0	0.021553	0	6	27										A	124746337	G	A	124746337	3	1	45	1	0	0	0	0	1	0	0	0	7044	1290	45	1	3580	1	HEG1	3	124746337	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	12749687	124746337	73276093	64	11527										
TPRA1	131601	broad.mit.edu	37	chr3	127295478	127295478	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acctgggtgacagagtaggcCagggacagcactgtggtgat	16	8	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:127295478C>T	uc003ejl.2	-	5	771	c.480G>A	c.(478-480)CTG>CTA	p.L160L	TPRA1_uc003ejm.2_RNA|TPRA1_uc003ejo.2_Silent_p.L160L|TPRA1_uc010hsk.2_Silent_p.L160L|TPRA1_uc003ejn.2_Silent_p.L160L	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	160	Helical; Name=4; (Potential).				aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						CAGAGTAGGCCAGGGACAGCA	0.617													0	0	0	0.115264	0	3	14										T	127295478	C	T	127295478	2	4	45	1	0	0	0	0	0	0	0	1	16414	581	21	2		2	TPRA1	3	127295478	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	2549141	127295478	70726952	65	11528										
EPHB1	2047	broad.mit.edu	37	chr3	134920360	134920360	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atccagcttgtgggtatgctCaggggcatcgctgctggcat	14	10	1	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:134920360C>G	uc003eqt.2	+	12	2395	c.2175C>G	c.(2173-2175)CTC>CTG	p.L725L	EPHB1_uc003equ.2_Silent_p.L286L	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	725	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGGGTATGCTCAGGGGCATCG	0.507													0	0	0	0.139131	0	54	139										G	134920360	C	G	134920360	2	3	45	1	0	0	0	0	0	0	0	1	5174	813	29	1		1	EPHB1	3	134920360	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	7624882	134920360	63102070	66	11529										
PCCB	5096	broad.mit.edu	37	chr3	136045670	136045670	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttggatattaattcatctgtGaaaggggctcgttttgtcag	11	5	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:136045670G>C	uc003eqy.1	+	11	1167	c.1116G>C	c.(1114-1116)GTG>GTC	p.V372V	PCCB_uc003eqz.1_Silent_p.V372V|PCCB_uc011bmc.1_Silent_p.V392V|PCCB_uc011bmd.1_Silent_p.V289V	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	372	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	ATTCATCTGTGAAAGGGGCTC	0.408													0	0	0	0.117977	0	44	208										C	136045670	G	C	136045670	2	2	45	1	0	0	0	0	0	0	0	1	11505	1277	45	1		1	PCCB	3	136045670	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	1125310	136045670	61976760	67	11530										
CP	1356	broad.mit.edu	37	chr3	148897410	148897410	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aatcctctgttccagctccaGatctttctgggattttccat	6	12	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:148897410G>A	uc003ewy.3	-	15	2847	c.2594C>T	c.(2593-2595)TCT>TTT	p.S865F	CP_uc011bnr.1_RNA|CP_uc003eww.3_Missense_Mutation_p.S17F|CP_uc003ewx.3_Missense_Mutation_p.S646F|CP_uc003ewz.2_Missense_Mutation_p.S865F	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	865	Plastocyanin-like 5.|F5/8 type A 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TCCAGCTCCAGATCTTTCTGG	0.333													0	0	0	0.09319	0	11	68										A	148897410	G	A	148897410	3	1	45	1	0	0	0	0	1	0	0	0	3787	942	33	1	623	1	CP	3	148897410	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	12851740	148897410	49125020	68	11531										
PLCH1	23007	broad.mit.edu	37	chr3	155232664	155232664	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttccacctgatgctcagtggTcccattactctgcaaagaat	7	12	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:155232664T>A	uc011bok.1	-	11	1721	c.1444A>T	c.(1444-1446)ACC>TCC	p.T482S	PLCH1_uc011boj.1_Missense_Mutation_p.T482S|PLCH1_uc011bol.1_Missense_Mutation_p.T464S	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	482					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGCTCAGTGGTCCCATTACTC	0.348													0	0	0	0.038395	0	18	55										A	155232664	T	A	155232664	3	1	45	1	0	0	0	0	1	0	0	0	12037	1667	58	5	3704	5	PLCH1	3	155232664	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08	6335254	155232664	42789766	69	11532										
TRIM59	286827	broad.mit.edu	37	chr3	160156757	160156757	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgcaaaattaacaggtaaaGattcaatgccagttggagca	10	6	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:160156757G>C	uc003fdm.2	-	3	410	c.215C>G	c.(214-216)TCT>TGT	p.S72C	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	72						integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AACAGGTAAAGATTCAATGCC	0.393													0	0	0	0.086207	0	41	123										C	160156757	G	C	160156757	3	2	45	1	0	0	0	0	1	0	0	0	16529	942	33	1	1000	1	TRIM59	3	160156757	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	4924093	160156757	37865673	70	11533										
PIK3CA	5290	broad.mit.edu	37	chr3	178952074	178952074	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagtatttcatgaaacaaatGaatgatgcacatcatggtgg	10	5	2	3	rs121913283		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:178952074G>T	uc003fjk.2	+	21	3286	c.3129G>T	c.(3127-3129)ATG>ATT	p.M1043I		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043I(33)|p.M1043V(14)|p.M1043T(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAACAAATGAATGATGCAC	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			1	0	2.4375e-19	0.125774	2.7683e-19	28	55										T	178952074	G	T	178952074	3	4	45	1	0	0	0	0	1	0	0	0	11913	1290	45	3	3207	3	PIK3CA	3	178952074	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	18795317	178952074	19070356	71	11534										
USP13	8975	broad.mit.edu	37	chr3	179399668	179399668	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tttttctctttcttctagaaTtctgaaggtggactctatgt	7	7	5	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:179399668T>A	uc003fkh.2	+	2	252	c.171T>A	c.(169-171)AAT>AAA	p.N57K	USP13_uc003fkf.2_Missense_Mutation_p.N57K	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	57					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TCTTCTAGAATTCTGAAGGTG	0.423													0	0	0	0.139131	0	73	205										A	179399668	T	A	179399668	3	1	45	1	0	0	0	0	1	0	0	0	17041	1490	52	5	177	5	USP13	3	179399668	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08	447594	179399668	18622762	72	11535										
IQCG	84223	broad.mit.edu	37	chr3	197616472	197616472	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cacttcttcttgcctctcctCttatccttgcctttaccttt	2	16	4	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr3:197616472C>G	uc003fyo.2	-	11	1457	c.1311G>C	c.(1309-1311)AAG>AAC	p.K437N	IQCG_uc003fyn.2_Missense_Mutation_p.K339N|IQCG_uc003fyp.2_Missense_Mutation_p.K437N|IQCG_uc003fym.2_Missense_Mutation_p.K138N	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	437											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TGCCTCTCCTCTTATCCTTGC	0.443													0	0	0	0.014758	0	4	184										G	197616472	C	G	197616472	3	3	45	1	0	0	0	0	1	0	0	0	7810	912	32	1	24	1	IQCG	3	197616472	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	18216804	197616472	405958	73	11536										
JAKMIP1	152789	broad.mit.edu	37	chr4	6087327	6087327	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccttctccaaggccagaatCacacggtctttccctttgat	6	14	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:6087327C>G	uc003giu.3	-	4	930	c.654G>C	c.(652-654)GTG>GTC	p.V218V	JAKMIP1_uc010idb.1_Silent_p.V218V|JAKMIP1_uc010idc.1_Silent_p.V53V|JAKMIP1_uc010idd.1_Silent_p.V218V|JAKMIP1_uc011bwc.1_Silent_p.V53V|JAKMIP1_uc003giv.3_Silent_p.V218V|JAKMIP1_uc010ide.2_Silent_p.V218V	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	218	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						AGGCCAGAATCACACGGTCTT	0.522													0	0	0	0.059317	0	35	117										G	6087327	C	G	6087327	2	3	45	1	0	0	0	0	0	0	0	1	7940	813	29	1		1	JAKMIP1	4	6087327	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		6087327	185066949	74	11537										
WDR1	9948	broad.mit.edu	37	chr4	10083020	10083020	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acggcgtatcccccggggccGacggctacgcactttggctg	14	15	0	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:10083020G>A	uc003gmf.2	-	11	1528	c.1245C>T	c.(1243-1245)GTC>GTT	p.V415V	WDR1_uc003gmg.2_Silent_p.V275V|WDR1_uc010idm.2_RNA|hsa-mir-3138|MI0014161_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	415					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CCCCGGGGCCGACGGCTACGC	0.567													0	0	0	0.132662	0	14	31										A	10083020	G	A	10083020	2	1	45	1	0	0	0	0	0	0	0	1	17269	1045	37	1		1	WDR1	4	10083020	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3995693	10083020	181071256	75	11538										
ATP10D	57205	broad.mit.edu	37	chr4	47593107	47593107	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgtttccatctccaattctGagagctaagcactttgacag	7	11	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:47593107G>C	uc003gxk.1	+	23	4154	c.3990G>C	c.(3988-3990)CTG>CTC	p.L1330L	ATP10D_uc003gxl.1_Silent_p.L578L	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1330	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CTCCAATTCTGAGAGCTAAGC	0.413													0	0	0	0.134883	0	30	92										C	47593107	G	C	47593107	2	2	45	1	0	0	0	0	0	0	0	1	1118	1277	45	1		1	ATP10D	4	47593107	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	37510087	47593107	143561169	76	11539										
GNRHR	2798	broad.mit.edu	37	chr4	68619664	68619664	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aggctgatcaccaccatcatGaaggctggggcatacatgga	12	10	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:68619664G>A	uc003hdn.2	-	1	2141	c.390C>T	c.(388-390)TTC>TTT	p.F130F	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Silent_p.F130F	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	130	Helical; Name=3; (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	CCACCATCATGAAGGCTGGGG	0.507													0	0	0	0.105934	0	12	42										A	68619664	G	A	68619664	2	1	45	1	0	0	0	0	0	0	0	1	6549	1281	45	1		1	GNRHR	4	68619664	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	21026557	68619664	122534612	77	11540										
MANBA	4126	broad.mit.edu	37	chr4	103595103	103595103	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aggttactcggtcctggaatGaatctgctgggatccagttt	12	8	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:103595103G>A	uc003hwg.2	-	8	1185	c.1085C>T	c.(1084-1086)TCA>TTA	p.S362L	MANBA_uc011ces.1_Missense_Mutation_p.S305L	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	362					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GTCCTGGAATGAATCTGCTGG	0.368													0	0	0	0.074837	0	36	104										A	103595103	G	A	103595103	3	1	45	1	0	0	0	0	1	0	0	0	9219	1294	45	1	1594	1	MANBA	4	103595103	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	34975439	103595103	87559173	78	11541										
LEF1	51176	broad.mit.edu	37	chr4	109004529	109004529	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taccagccaagaggtggggtGatctgtccaacaccacccgg	12	13	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:109004529G>A	uc003hyt.1	-	5	1276	c.621C>T	c.(619-621)ATC>ATT	p.I207I	LEF1_uc011cfj.1_Silent_p.I92I|LEF1_uc011cfk.1_Silent_p.I139I|LEF1_uc003hyu.1_Silent_p.I207I|LEF1_uc003hyv.1_Silent_p.I207I|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	207	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GAGGTGGGGTGATCTGTCCAA	0.463													0	0	0	0.043863	0	18	39										A	109004529	G	A	109004529	2	1	45	1	0	0	0	0	0	0	0	1	8714	1280	45	1		1	LEF1	4	109004529	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	5409426	109004529	82149747	79	11542										
NAA15	80155	broad.mit.edu	37	chr4	140309202	140309202	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atcacagttaatggagatagTtctgcagaagctgaagaact	10	6	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:140309202T>A	uc003ihu.1	+	20	2821	c.2565T>A	c.(2563-2565)AGT>AGA	p.S855R		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	855					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						ATGGAGATAGTTCTGCAGAAG	0.353													0	0	0	0.064281	0	36	85										A	140309202	T	A	140309202	3	1	45	1	0	0	0	0	1	0	0	0	10118	1722	60	5	2643	5	NAA15	4	140309202	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08	31304673	140309202	50845074	80	11543										
CLGN	1047	broad.mit.edu	37	chr4	141320087	141320087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttttttatcattgggatcttCaatttctttgggaggtttga	9	4	4	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:141320087C>G	uc011chi.1	-	9	1020	c.802G>C	c.(802-804)GAA>CAA	p.E268Q	CLGN_uc003iii.2_Missense_Mutation_p.E268Q	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	268	Lumenal (Potential).|1-1.				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					TTGGGATCTTCAATTTCTTTG	0.408													0	0	0	0.047766	0	9	215										G	141320087	C	G	141320087	3	3	45	1	0	0	0	0	1	0	0	0	3524	835	29	1	1062	1	CLGN	4	141320087	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1010885	141320087	49834189	81	11544										
SMARCA5	8467	broad.mit.edu	37	chr4	144469207	144469207	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acaaacttggatttgacaaaGaaaatgtttatgatgaattg	8	3	0	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:144469207G>C	uc003ijg.2	+	22	3361	c.2899G>C	c.(2899-2901)GAA>CAA	p.E967Q		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	967	SANT 2.				CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)					ATTTGACAAAGAAAATGTTTA	0.373													0	0	0	0.099896	0	27	69										C	144469207	G	C	144469207	3	2	45	1	0	0	0	0	1	0	0	0	14771	943	33	1	2985	1	SMARCA5	4	144469207	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3149120	144469207	46685069	82	11545										
ARFIP1	27236	broad.mit.edu	37	chr4	153791962	153791962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tagcagggttgcagctagtcGactggctcagcaaggaagtg	15	8	1	0	rs142219628		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr4:153791962G>A	uc003imz.2	+	4	536	c.260G>A	c.(259-261)CGA>CAA	p.R87Q	ARFIP1_uc003inb.2_Intron|ARFIP1_uc003ina.2_Intron|ARFIP1_uc003inc.2_Missense_Mutation_p.R87Q|ARFIP1_uc011cij.1_Intron	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	87					intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					GCAGCTAGTCGACTGGCTCAG	0.443													0	0	0	0.049695	0	19	66										A	153791962	G	A	153791962	3	1	45	1	0	0	0	0	1	0	0	0	854	1058	37	1	270	1	ARFIP1	4	153791962	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	9322755	153791962	37362314	83	11546										
ADCY2	108	broad.mit.edu	37	chr5	7817056	7817056	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtagggaagctggatgccatCaacaagcactccttcaacga	10	11	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:7817056C>T	uc003jdz.1	+	23	3028	c.2961C>T	c.(2959-2961)ATC>ATT	p.I987I	ADCY2_uc011cmo.1_Silent_p.I807I|ADCY2_uc010itm.1_Silent_p.I183I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	987	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TGGATGCCATCAACAAGCACT	0.502											OREG0016499	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.132662	0	15	52										T	7817056	C	T	7817056	2	4	45	1	0	0	0	0	0	0	0	1	294	816	29	1		1	ADCY2	5	7817056	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		7817056	173098204	84	11547										
MARCH6	10299	broad.mit.edu	37	chr5	10391798	10391798	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aggacaatgaggaggaagatGacgctggtgtggaggatgcg	19	4	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:10391798G>A	uc003jet.1	+	7	904	c.721G>A	c.(721-723)GAC>AAC	p.D241N	MARCH6_uc011cmu.1_Missense_Mutation_p.D193N|MARCH6_uc003jeu.1_5'UTR|MARCH6_uc011cmv.1_Missense_Mutation_p.D136N	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	241	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						ggaggaagatgaCGCTGGTGT	0.423													0	0	0	0.021553	0	6	18										A	10391798	G	A	10391798	3	1	45	1	0	0	0	0	1	0	0	0	9305	1290	45	1	747	1	MARCH6	5	10391798	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2574742	10391798	170523462	85	11548										
C5orf42	65250	broad.mit.edu	37	chr5	37185055	37185055	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagcctcatctggtttctctTcttcaattggttcccatata	6	11	5	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:37185055T>A	uc011cpa.1	-	25	4547	c.4316A>T	c.(4315-4317)GAA>GTA	p.E1439V	C5orf42_uc011coy.1_5'Flank|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.E514V|C5orf42_uc011cpb.1_Missense_Mutation_p.E320V	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1439										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGGTTTCTCTTCTTCAATTGG	0.428													0	0	0	0.117977	0	43	101										A	37185055	T	A	37185055	3	1	45	1	0	0	0	0	1	0	0	0	2301	1783	62	5	5389	5	C5orf42	5	37185055	Missense_Mutation	SNP	T	TCGA-DK-A1AB-01A-11D-A13W-08	26793257	37185055	143730205	86	11549										
PAIP1	10605	broad.mit.edu	37	chr5	43533846	43533846	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgagacaacatacctggatCagctgcagtgaaaggaacac	11	9	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:43533846C>T	uc003job.2	-	9	1493	c.1246G>A	c.(1246-1248)GAT>AAT	p.D416N	PAIP1_uc003joa.2_Missense_Mutation_p.D337N|PAIP1_uc010ivp.2_Missense_Mutation_p.D337N|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.D304N	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	416					mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATACCTGGATCAGCTGCAGTG	0.358													0	0	0	0.134883	0	30	130										T	43533846	C	T	43533846	3	4	45	1	0	0	0	0	1	0	0	0	11396	826	29	1	205	1	PAIP1	5	43533846	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	6348791	43533846	137381414	87	11550										
ZFYVE16	9765	broad.mit.edu	37	chr5	79732916	79732916	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgacatgggtaacttagttCatgcaaccaatagtgaagaa	10	6	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:79732916C>T	uc003kgr.3	+	4	714	c.412C>T	c.(412-414)CAT>TAT	p.H138Y	ZFYVE16_uc010jak.1_Missense_Mutation_p.H138Y|ZFYVE16_uc003kgp.2_Missense_Mutation_p.H138Y|ZFYVE16_uc003kgq.3_Missense_Mutation_p.H138Y|ZFYVE16_uc003kgs.3_Missense_Mutation_p.H138Y	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	138					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TAACTTAGTTCATGCAACCAA	0.358													0	0	0	0.146539	0	17	245										T	79732916	C	T	79732916	3	4	45	1	0	0	0	0	1	0	0	0	17661	826	29	1	418	1	ZFYVE16	5	79732916	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	36199070	79732916	101182344	88	11551										
NR2F1	7025	broad.mit.edu	37	chr5	92929285	92929285	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagacgcctgtggcctgtcgGatgcggcccacatcgagagc	14	14	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:92929285G>A	uc003kkj.2	+	3	2696	c.1009G>A	c.(1009-1011)GAT>AAT	p.D337N		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	337					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		TGGCCTGTCGGATGCGGCCCA	0.587													0	0	0	0.134883	0	28	90										A	92929285	G	A	92929285	3	1	45	1	0	0	0	0	1	0	0	0	10627	1174	41	1	1019	1	NR2F1	5	92929285	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	13196369	92929285	87985975	89	11552										
SLCO6A1	133482	broad.mit.edu	37	chr5	101834305	101834305	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gggctgctccaaactgtcatCcacttctcccggcttcttgg	9	15	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:101834305C>G	uc003knn.2	-	1	416	c.244G>C	c.(244-246)GAT>CAT	p.D82H	SLCO6A1_uc003kno.2_Missense_Mutation_p.D82H|SLCO6A1_uc003knp.2_Missense_Mutation_p.D82H|SLCO6A1_uc003knq.2_Missense_Mutation_p.D82H	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	82	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAACTGTCATCCACTTCTCCC	0.493													0	0	0	0.139131	0	61	115										G	101834305	C	G	101834305	3	3	45	1	0	0	0	0	1	0	0	0	14732	855	30	1	1967	1	SLCO6A1	5	101834305	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	8905020	101834305	79080955	90	11553										
TSSK1B	83942	broad.mit.edu	37	chr5	112770004	112770004	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctggggccgcatacgctggtGacccacagaaggtcttgctt	13	12	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:112770004G>A	uc003kqm.2	-	1	725	c.533C>T	c.(532-534)TCA>TTA	p.S178L	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	178	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		ATACGCTGGTGACCCACAGAA	0.567													0	0	0	0.038147	0	7	28										A	112770004	G	A	112770004	3	1	45	1	0	0	0	0	1	0	0	0	16665	1294	45	1	574	1	TSSK1B	5	112770004	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	10935699	112770004	68145256	91	11554										
MEGF10	84466	broad.mit.edu	37	chr5	126734416	126734416	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	catggtccacagtgtgagcaGagatgcccttgtcaaaatgg	12	9	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:126734416G>C	uc003kuh.3	+	8	1070	c.708G>C	c.(706-708)CAG>CAC	p.Q236H	MEGF10_uc010jdc.1_Missense_Mutation_p.Q236H|MEGF10_uc010jdd.1_Missense_Mutation_p.Q236H|MEGF10_uc003kui.3_Missense_Mutation_p.Q236H	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	236	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 4.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGTGTGAGCAGAGATGCCCTT	0.507													0	0	0	0.069288	0	23	71										C	126734416	G	C	126734416	3	2	45	1	0	0	0	0	1	0	0	0	9460	933	33	1	730	1	MEGF10	5	126734416	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	13964412	126734416	54180844	92	11555										
FCHSD1	89848	broad.mit.edu	37	chr5	141025388	141025388	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcctcactgagccgccgctCctgctccacctcatcctggg	9	19	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:141025388C>G	uc003llk.2	-	13	1312	c.1261G>C	c.(1261-1263)GAG>CAG	p.E421Q	FCHSD1_uc010jgg.2_Missense_Mutation_p.E104Q|FCHSD1_uc003llj.2_RNA	NM_033449	NP_258260	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	421									FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCGCCGCTCCTGCTCCACC	0.642													0	0	0	0.047766	0	4	9										G	141025388	C	G	141025388	3	3	45	1	0	0	0	0	1	0	0	0	5789	864	30	1	843	1	FCHSD1	5	141025388	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	14290972	141025388	39889872	93	11556										
GABRB2	2561	broad.mit.edu	37	chr5	160758051	160758051	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gcaccccatcaggtacatgtCaatggccttcacatagggga	10	12	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:160758051C>T	uc003lys.1	-	9	1134	c.916G>A	c.(916-918)GAC>AAC	p.D306N	GABRB2_uc011deh.1_Missense_Mutation_p.D145N|GABRB2_uc003lyr.1_Missense_Mutation_p.D306N|GABRB2_uc003lyt.1_Missense_Mutation_p.D306N|GABRB2_uc010jiu.1_Missense_Mutation_p.D243N	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	306	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGGTACATGTCAATGGCCTTC	0.483													0	0	0	0.139131	0	58	134										T	160758051	C	T	160758051	3	4	45	1	0	0	0	0	1	0	0	0	6167	826	29	1	634	1	GABRB2	5	160758051	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	19732663	160758051	20157209	94	11557										
PDLIM7	9260	broad.mit.edu	37	chr5	176910713	176910713	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggagtagaaggtctttccttCcaggttgatctgacatatct	10	8	3	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:176910713C>G	uc003mhc.1	-	13	1391	c.1306G>C	c.(1306-1308)GAA>CAA	p.E436Q	PDLIM7_uc003mha.1_Missense_Mutation_p.E330Q|PDLIM7_uc003mhb.1_Missense_Mutation_p.E402Q|PDLIM7_uc003mhd.1_Missense_Mutation_p.E288Q|PDLIM7_uc003mhe.1_RNA	NM_005451	NP_005442	Q9NR12	PDLI7_HUMAN	PDZ and LIM domain 7 isoform 1	436	LIM zinc-binding 3.				cell differentiation|multicellular organismal development|ossification|receptor-mediated endocytosis	cytoplasm|focal adhesion	protein binding|zinc ion binding			breast(1)	1	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTCTTTCCTTCCAGGTTGATC	0.587													0	0	0	0.021553	0	6	27										G	176910713	C	G	176910713	3	3	45	1	0	0	0	0	1	0	0	0	11684	864	30	1	71	1	PDLIM7	5	176910713	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	16152662	176910713	4004547	95	11558										
TBC1D9B	23061	broad.mit.edu	37	chr5	179318451	179318451	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagatgtagttgttggagatGaacatctggccagggatgtg	15	5	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr5:179318451G>A	uc003mlh.2	-	6	1009	c.972C>T	c.(970-972)TTC>TTT	p.F324F	TBC1D9B_uc003mli.2_Silent_p.F324F|TBC1D9B_uc003mlj.2_Silent_p.F324F	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	324	GRAM 2.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTTGGAGATGAACATCTGGC	0.597													0	0	0	0.054565	0	32	61										A	179318451	G	A	179318451	2	1	45	1	0	0	0	0	0	0	0	1	15625	1281	45	1		1	TBC1D9B	5	179318451	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2407738	179318451	1596809	96	11559										
DSP	1832	broad.mit.edu	37	chr6	7581491	7581491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcatttccagaaggcgataGaagataaaagcagaagctta	10	6	0	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:7581491G>A	uc003mxp.1	+	23	5347	c.5068G>A	c.(5068-5070)GAA>AAA	p.E1690K	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1690	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAAGGCGATAGAAGATAAAAG	0.458													0	0	0	0.134883	0	31	57										A	7581491	G	A	7581491	3	1	45	1	0	0	0	0	1	0	0	0	4781	943	33	1	5158	1	DSP	6	7581491	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		7581491	163533576	97	11560										
HIST1H3I	8354	broad.mit.edu	37	chr6	27839872	27839872	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtcttaaagtcctgtgcgatCtcccgtaccaagcgctgaaa	9	12	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:27839872C>T	uc003njy.2	-	1	228	c.222G>A	c.(220-222)GAG>GAA	p.E74E		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	74					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CCTGTGCGATCTCCCGTACCA	0.622													0	0	0	0.116897	0	28	38										T	27839872	C	T	27839872	2	4	45	1	0	0	0	0	0	0	0	1	7163	912	32	1		1	HIST1H3I	6	27839872	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	20258381	27839872	143275195	98	11561										
BAT3	7917	broad.mit.edu	37	chr6	31617000	31617000	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agattgaaggttccaaccatGacatagctgttggcattccg	10	9	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:31617000G>A	uc003nvg.3	-	4	713	c.399C>T	c.(397-399)GTC>GTT	p.V133V	BAT3_uc003nvf.3_Silent_p.V133V|BAT3_uc003nvh.3_Silent_p.V133V|BAT3_uc003nvi.3_Silent_p.V133V|BAT3_uc011dnw.1_Silent_p.V133V|BAT3_uc011dnx.1_Silent_p.V133V|BAT3_uc003nvj.1_Silent_p.V133V	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	133					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						TTCCAACCATGACATAGCTGT	0.552													0	0	0	0.117977	0	45	67										A	31617000	G	A	31617000	2	1	45	1	0	0	0	0	0	0	0	1	1322	1277	45	1		1	BAT3	6	31617000	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3777128	31617000	139498067	99	11562										
TNXB	7148	broad.mit.edu	37	chr6	32017875	32017875	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggctccaggcctgagatggtGaccccgtcctcgtgccccgg	14	16	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:32017875G>A	uc003nzl.2	-	27	9535	c.9333C>T	c.(9331-9333)GTC>GTT	p.V3111V		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3158	Fibronectin type-III 23.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTGAGATGGTGACCCCGTCCT	0.632													0	0	0	0.0333	0	15	14										A	32017875	G	A	32017875	2	1	45	1	0	0	0	0	0	0	0	1	16343	1277	45	1		1	TNXB	6	32017875	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	400875	32017875	139097192	100	11563										
PPP2R5D	5528	broad.mit.edu	37	chr6	42978430	42978430	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccgaatgaaggaaagggaaGagatgtggcaaaaaatcgag	14	4	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:42978430G>C	uc003oth.2	+	14	1596	c.1510G>C	c.(1510-1512)GAG>CAG	p.E504Q	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Missense_Mutation_p.E472Q|PPP2R5D_uc010jyd.2_Missense_Mutation_p.E398Q|PPP2R5D_uc011dva.1_Missense_Mutation_p.E353Q|PPP2R5D_uc003oti.2_Missense_Mutation_p.E353Q|PPP2R5D_uc003otj.2_Missense_Mutation_p.E335Q	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	504					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GGAAAGGGAAGAGATGTGGCA	0.542													0	0	0	0.069288	0	22	38										C	42978430	G	C	42978430	3	2	45	1	0	0	0	0	1	0	0	0	12395	943	33	1	1564	1	PPP2R5D	6	42978430	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	10960555	42978430	128136637	101	11564										
CUL9	23113	broad.mit.edu	37	chr6	43156401	43156401	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgccctctctcaggctgtgGaggaggtcactgagcgggac	15	12	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:43156401G>C	uc003ouk.2	+	8	2203	c.2128G>C	c.(2128-2130)GAG>CAG	p.E710Q	CUL9_uc003ouj.1_3'UTR|CUL9_uc003oul.2_Missense_Mutation_p.E710Q|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_3'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	710					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						TCAGGCTGTGGAGGAGGTCAC	0.577													0	0	0	0.11911	0	15	22										C	43156401	G	C	43156401	3	2	45	1	0	0	0	0	1	0	0	0	4061	1175	41	1	2154	1	CUL9	6	43156401	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	177971	43156401	127958666	102	11565										
COL12A1	1303	broad.mit.edu	37	chr6	75843060	75843060	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atcaccttcagtataaacggGaactacagtcacagtgtatg	8	9	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:75843060G>T	uc003phs.2	-	34	5909	c.5743C>A	c.(5743-5745)CCC>ACC	p.P1915T	COL12A1_uc003pht.2_Missense_Mutation_p.P751T	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1915	Fibronectin type-III 14.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GTATAAACGGGAACTACAGTC	0.373													1	0	5.61819e-17	0.108266	6.31302e-17	27	59										T	75843060	G	T	75843060	3	4	45	1	0	0	0	0	1	0	0	0	3669	1174	41	3	3580	3	COL12A1	6	75843060	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	32686659	75843060	95272007	103	11566										
RIPPLY2	134701	broad.mit.edu	37	chr6	84563822	84563822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cctttcctctccagatgcccGatggccctggaatgaccgca	9	16	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr6:84563822G>A	uc003pke.2	+	3	332	c.181G>A	c.(181-183)GAT>AAT	p.D61N		NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	ripply2 protein	61					somite rostral/caudal axis specification	nucleus					0						CCAGATGCCCGATGGCCCTGG	0.577													0	0	0	0.049695	0	17	34										A	84563822	G	A	84563822	3	1	45	1	0	0	0	0	1	0	0	0	13385	1058	37	1	191	1	RIPPLY2	6	84563822	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	8720762	84563822	86551245	104	11567										
DGKB	1607	broad.mit.edu	37	chr7	14733765	14733765	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccttgaatccattcctccaGagacacggttccatcatgat	6	13	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:14733765G>A	uc003ssz.2	-	8	833	c.646C>T	c.(646-648)CTG>TTG	p.L216L	DGKB_uc011jxt.1_Silent_p.L209L|DGKB_uc003sta.2_Silent_p.L216L|DGKB_uc011jxu.1_Silent_p.L216L|DGKB_uc011jxv.1_Silent_p.L216L	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	216	EF-hand 2.|2 (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CATTCCTCCAGAGACACGGTT	0.443													0	0	0	0.038147	0	6	7										A	14733765	G	A	14733765	2	1	45	1	0	0	0	0	0	0	0	1	4466	933	33	1		1	DGKB	7	14733765	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		14733765	144404898	105	11568										
AHR	196	broad.mit.edu	37	chr7	17378911	17378911	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttgaaaacaactttttcaacGaatctatgaatgaatgcaga	6	6	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:17378911G>T	uc011jxz.1	+	10	2075	c.1462G>T	c.(1462-1464)GAA>TAA	p.E488*	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	488					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CTTTTTCAACGAATCTATGAA	0.398													1	0	8.01111e-26	0.117977	9.13094e-26	44	122										T	17378911	G	T	17378911	4	4	45	1	0	0	0	0	0	1	0	0	416	1059	37	3	1500	3	AHR	7	17378911	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2645146	17378911	141759752	106	11569										
GTF2IRD1	9569	broad.mit.edu	37	chr7	73933938	73933938	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccccaaccacgccatccgaGagctcaagcaggaagcacct	8	17	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:73933938G>C	uc003uaq.2	+	6	1198	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.E301Q|GTF2IRD1_uc003uap.2_Missense_Mutation_p.E269Q|GTF2IRD1_uc003uar.1_Missense_Mutation_p.E269Q	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	269						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CGCCATCCGAGAGCTCAAGCA	0.687													0	0	0	0.09319	0	12	45										C	73933938	G	C	73933938	3	2	45	1	0	0	0	0	1	0	0	0	6868	943	33	1	823	1	GTF2IRD1	7	73933938	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	56555027	73933938	85204725	107	11570										
SRCRB4D	136853	broad.mit.edu	37	chr7	76033741	76033741	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctggggaccaattagcatctCtgcttccttgtgcatctaga	9	11	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:76033741C>T	uc003ufb.2	-	2	364	c.16G>A	c.(16-18)GAG>AAG	p.E6K	ZP3_uc003ufc.3_Intron	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	6						extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						ATTAGCATCTCTGCTTCCTTG	0.542													0	0	0	0.058154	0	10	71										T	76033741	C	T	76033741	3	4	45	1	0	0	0	0	1	0	0	0	15136	922	32	1	1751	1	SRCRB4D	7	76033741	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	2099803	76033741	83104922	108	11571										
RSBN1L	222194	broad.mit.edu	37	chr7	77408178	77408178	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tttttcagataaacttcattCtaaatatgaattacagcaga	4	6	3	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:77408178C>G	uc010ldt.1	+	8	2278	c.2234C>G	c.(2233-2235)TCT>TGT	p.S745C	RSBN1L_uc003ugm.2_Missense_Mutation_p.S527C	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	745						nucleus				ovary(1)	1						AAACTTCATTCTAAATATGAA	0.363													0	0	0	0.050027	0	35	85										G	77408178	C	G	77408178	3	3	45	1	0	0	0	0	1	0	0	0	13697	913	32	1	2264	1	RSBN1L	7	77408178	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1374437	77408178	81730485	109	11572										
ACN9	57001	broad.mit.edu	37	chr7	96810512	96810512	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tttagtatttctgagtctatGaaaccaaaattttagtctat	5	5	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:96810512G>C	uc003uoo.3	+	2	1494	c.363G>C	c.(361-363)ATG>ATC	p.M121I		NM_020186	NP_064571	Q9NRP4	ACN9_HUMAN	ACN9 homolog precursor	121					regulation of gluconeogenesis	mitochondrial intermembrane space					0	all_cancers(62;2.54e-08)|all_epithelial(64;2.24e-08)|Esophageal squamous(72;0.00507)|all_lung(186;0.154)|Lung NSC(181;0.159)					CTGAGTCTATGAAACCAAAAT	0.318													0	0	0	0.058154	0	9	30										C	96810512	G	C	96810512	3	2	45	1	0	0	0	0	1	0	0	0	145	1290	45	1	369	1	ACN9	7	96810512	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	19402334	96810512	62328151	110	11573										
OR2F2	135948	broad.mit.edu	37	chr7	143633147	143633147	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtccttcaagagaagctgatCtctgtcttctatgccattgt	8	10	4	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr7:143633147C>G	uc011ktv.1	+	1	822	c.822C>G	c.(820-822)ATC>ATG	p.I274M		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					AGAAGCTGATCTCTGTCTTCT	0.483													0	0	0	0.083992	0	23	78										G	143633147	C	G	143633147	3	3	45	1	0	0	0	0	1	0	0	0	10997	903	32	1	824	1	OR2F2	7	143633147	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	46822635	143633147	15505516	111	11574										
SOX7	83595	broad.mit.edu	37	chr8	10584142	10584142	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gcctcgtccacgtacggcctCttctgggacagcgtcagcgc	12	16	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:10584142C>G	uc003wtf.2	-	2	352	c.273G>C	c.(271-273)AAG>AAC	p.K91N	SOX7_uc011kwz.1_Missense_Mutation_p.K143N|uc003wtg.1_5'Flank	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	91	HMG box.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		CGTACGGCCTCTTCTGGGACA	0.602													0	0	0	0.047766	0	6	16										G	10584142	C	G	10584142	3	3	45	1	0	0	0	0	1	0	0	0	14956	912	32	1	897	1	SOX7	8	10584142	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		10584142	135779880	112	11575										
MTUS1	57509	broad.mit.edu	37	chr8	17612647	17612647	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gttttcaaagctttctctatCataagtagtttctcttgcat	5	8	4	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:17612647C>G	uc003wxv.2	-	2	1144	c.670G>C	c.(670-672)GAT>CAT	p.D224H	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.D224H|MTUS1_uc010lsz.2_Missense_Mutation_p.D224H	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	224						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		CTTTCTCTATCATAAGTAGTT	0.418													0	0	0	0.083992	0	25	150										G	17612647	C	G	17612647	3	3	45	1	0	0	0	0	1	0	0	0	9965	826	29	1	3517	1	MTUS1	8	17612647	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	7028505	17612647	128751375	113	11576										
UNC5D	137970	broad.mit.edu	37	chr8	35406937	35406937	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	attgcactcaggtgcaaagcGaggccagccatgcagatatt	11	10	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:35406937G>A	uc003xjr.1	+	2	559	c.231G>A	c.(229-231)GCG>GCA	p.A77A	UNC5D_uc003xjs.1_Silent_p.A72A	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	77	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GGTGCAAAGCGAGGCCAGCCA	0.512													0	0	0	0.080935	0	12	39										A	35406937	G	A	35406937	2	1	45	1	0	0	0	0	0	0	0	1	16992	1045	37	1		1	UNC5D	8	35406937	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	17794290	35406937	110957085	114	11577										
SDCBP	6386	broad.mit.edu	37	chr8	59494245	59494245	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taaaagtacctctcttgtagGatggcaccaagcattatgaa	8	8	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:59494245G>C	uc003xtn.2	+	9	993	c.843G>C	c.(841-843)CGG>CGC	p.R281R	SDCBP_uc003xto.2_Silent_p.R280R|SDCBP_uc003xtr.2_Silent_p.R280R|SDCBP_uc003xtp.2_Silent_p.R275R|SDCBP_uc003xtq.2_Silent_p.R281R|SDCBP_uc003xts.2_Silent_p.R287R|SDCBP_uc011led.1_Silent_p.R222R	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	281					actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TCTCTTGTAGGATGGCACCAA	0.383													0	0	0	0.076483	0	24	71										C	59494245	G	C	59494245	2	2	45	1	0	0	0	0	0	0	0	1	13955	1188	41	1		1	SDCBP	8	59494245	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	24087308	59494245	86869777	115	11578										
ZFHX4	79776	broad.mit.edu	37	chr8	77764240	77764240	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cacagtcaccagcacaaattCagatgcaactacagcacgaa	6	13	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:77764240C>T	uc003yav.2	+	10	5335	c.4948C>T	c.(4948-4950)CAG>TAG	p.Q1650*	ZFHX4_uc003yau.1_Nonsense_Mutation_p.Q1695*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.Q1650*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1650	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCACAAATTCAGATGCAACT	0.428										HNSCC(33;0.089)			0	0	0	0.069288	0	23	61										T	77764240	C	T	77764240	4	4	45	1	0	0	0	0	0	1	0	0	17632	827	29	1	5117	1	ZFHX4	8	77764240	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	18269995	77764240	68599782	116	11579										
COX6C	1345	broad.mit.edu	37	chr8	100904266	100904266	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ccatggtagttactgtccttGatacgtatgctaaccttaag	8	9	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:100904266G>C	uc003yiy.1	-	2	44	c.-16C>G	c.(-18--14)ATCAA>ATGAA			NM_004374	NP_004365	P09669	COX6C_HUMAN	cytochrome c oxidase subunit VIc proprotein						respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity		HMGA2/COX6C(2)	soft_tissue(2)	2			all cancers(13;8.32e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TACTGTCCTTGATACGTAtgc	0.279			T	HMGA2	uterine leiomyoma								0	0	0	0.134883	0	28	73										C	100904266	G	C	100904266	1	2	45	1	0	0	0	0	0	0	0	0	3778	1305	45	1		1	COX6C	8	100904266	Translation_Start_Site	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	23140026	100904266	45459756	117	11580										
DPYS	1807	broad.mit.edu	37	chr8	105459566	105459566	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gcgtacctctgcaattaagtCtccattttccgcatggacct	7	13	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:105459566C>T	uc003yly.3	-	3	718	c.589G>A	c.(589-591)GAC>AAC	p.D197N		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	197					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCAATTAAGTCTCCATTTTCC	0.453													0	0	0	0.09319	0	12	34										T	105459566	C	T	105459566	3	4	45	1	0	0	0	0	1	0	0	0	4746	913	32	1	998	1	DPYS	8	105459566	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4555300	105459566	40904456	118	11581										
OXR1	55074	broad.mit.edu	37	chr8	107763046	107763046	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tattgcagaggagaatttgcGctttggcttgatggagatct	13	5	1	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:107763046G>A	uc011lht.1	+	16	2601	c.2502G>A	c.(2500-2502)GCG>GCA	p.A834A	OXR1_uc003ymf.2_Silent_p.A806A|OXR1_uc011lhu.1_Silent_p.A799A|OXR1_uc010mcg.2_RNA|OXR1_uc010mch.2_Silent_p.A462A|OXR1_uc003ymk.2_Silent_p.A203A|OXR1_uc003yml.2_Silent_p.A176A	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	834	TLD.				cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			GAGAATTTGCGCTTTGGCTTG	0.323													0	0	0	0.0918	0	25	115										A	107763046	G	A	107763046	2	1	45	1	0	0	0	0	0	0	0	1	11334	1074	38	2		2	OXR1	8	107763046	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2303480	107763046	38600976	119	11582										
CSMD3	114788	broad.mit.edu	37	chr8	113348981	113348981	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tacaagccaaaaacaatcttGaaagtttggatattcatcag	6	7	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:113348981G>A	uc003ynu.2	-	44	7078	c.6919C>T	c.(6919-6921)CAA>TAA	p.Q2307*	CSMD3_uc003yns.2_Nonsense_Mutation_p.Q1509*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.Q2267*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.Q2203*|CSMD3_uc003ynw.1_Nonsense_Mutation_p.Q18*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2307	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAACAATCTTGAAAGTTTGGA	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.064281	0	34	135										A	113348981	G	A	113348981	4	1	45	1	0	0	0	0	0	1	0	0	3946	1299	45	1	4316	1	CSMD3	8	113348981	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	5585935	113348981	33015041	120	11583										
MTBP	27085	broad.mit.edu	37	chr8	121530149	121530149	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agacaactggtaatagtaatCactatcatcatcatgtgaca	6	8	4	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr8:121530149C>T	uc003ypc.1	+	19	2350	c.2305C>T	c.(2305-2307)CAC>TAC	p.H769Y		NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	769	Interaction with MDM2 (By similarity).				cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			TAATAGTAATCACTATCATCA	0.393													0	0	0	0.0918	0	25	79										T	121530149	C	T	121530149	3	4	45	1	0	0	0	0	1	0	0	0	9912	826	29	1	2379	1	MTBP	8	121530149	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	8181168	121530149	24833873	121	11584										
FREM1	158326	broad.mit.edu	37	chr9	14776080	14776080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtcaggggaaagcaggcccaCggccccttgggccagtctca	14	14	2	0	rs61735747	by1000genomes	TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:14776080C>T	uc003zlm.2	-	25	5154	c.4564G>A	c.(4564-4566)GTG>ATG	p.V1522M	FREM1_uc010mic.2_Intron|FREM1_uc003zlk.2_5'Flank|FREM1_uc003zll.2_Missense_Mutation_p.V58M	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1522	CSPG 11.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AGCAGGCCCACGGCCCCTTGG	0.617													0	0	0	0.108266	0	27	67										T	14776080	C	T	14776080	3	4	45	1	0	0	0	0	1	0	0	0	6044	536	19	2	2027	2	FREM1	9	14776080	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		14776080	126437351	122	11585										
HAUS6	54801	broad.mit.edu	37	chr9	19082988	19082988	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	accgaactaacaacttctctCtctttttccaaaaacatgag	3	12	2	1	rs146901356		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:19082988C>G	uc003znk.2	-	8	1006	c.753G>C	c.(751-753)GAG>GAC	p.E251D	HAUS6_uc011lmz.1_Missense_Mutation_p.E6D|HAUS6_uc003znl.1_Missense_Mutation_p.E115D|HAUS6_uc003znm.1_Missense_Mutation_p.E6D	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	251					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						CAACTTCTCTCTCTTTTTCCA	0.353													0	0	0	0.049695	0	19	36										G	19082988	C	G	19082988	3	3	45	1	0	0	0	0	1	0	0	0	6970	912	32	1	2154	1	HAUS6	9	19082988	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4306908	19082988	122130443	123	11586										
KIF27	55582	broad.mit.edu	37	chr9	86457231	86457231	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttatgatcccggctggttttCttatagaaataaagatcttt	7	6	2	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:86457231C>G	uc004ana.2	-	17	3786	c.3642G>C	c.(3640-3642)AAG>AAC	p.K1214N	KIF27_uc010mpw.2_Missense_Mutation_p.K1148N|KIF27_uc010mpx.2_Missense_Mutation_p.K1117N	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1214	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						GGCTGGTTTTCTTATAGAAAT	0.368													0	0	0	0.0918	0	23	45										G	86457231	C	G	86457231	3	3	45	1	0	0	0	0	1	0	0	0	8296	912	32	1	571	1	KIF27	9	86457231	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	67374243	86457231	54756200	124	11587										
RNF20	56254	broad.mit.edu	37	chr9	104309797	104309797	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	actacacaaaatgaaaagctGaaggtaggaacgcatccctg	9	9	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:104309797G>A	uc004bbn.2	+	9	1179	c.1089G>A	c.(1087-1089)CTG>CTA	p.L363L		NM_019592	NP_062538	Q5VTR2	BRE1A_HUMAN	ring finger protein 20	363	Potential.				histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|breast(1)|kidney(1)|skin(1)	8		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		ATGAAAAGCTGAAGGTAGGAA	0.448													0	0	0	0.069234	0	11	29										A	104309797	G	A	104309797	2	1	45	1	0	0	0	0	0	0	0	1	13473	1277	45	1		1	RNF20	9	104309797	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	17852566	104309797	36903634	125	11588										
ABCA1	19	broad.mit.edu	37	chr9	107547853	107547853	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aaatgcaagtccaaagaaatCctggacaggcttcaggtccg	10	10	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:107547853C>G	uc004bcl.2	-	49	6782	c.6469G>C	c.(6469-6471)GAT>CAT	p.D2157H	NIPSNAP3B_uc004bcj.1_Intron	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	2157					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCAAAGAAATCCTGGACAGGC	0.438													0	0	0	0.059317	0	33	79										G	107547853	C	G	107547853	3	3	45	1	0	0	0	0	1	0	0	0	28	855	30	1	324	1	ABCA1	9	107547853	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	3238056	107547853	33665578	126	11589										
TRIM32	22954	broad.mit.edu	37	chr9	119460323	119460323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgtggggctgctcatgtgtcGgtcctgtgggcggcgtctgc	18	10	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:119460323G>A	uc004bjx.2	+	2	460	c.302G>A	c.(301-303)CGG>CAG	p.R101Q	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Missense_Mutation_p.R101Q	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	101					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						CTCATGTGTCGGTCCTGTGGG	0.597									Bardet-Biedl_syndrome				0	0	0	0.134883	0	25	78										A	119460323	G	A	119460323	3	1	45	1	0	0	0	0	1	0	0	0	16503	1116	39	2	304	2	TRIM32	9	119460323	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	11912470	119460323	21753108	127	11590										
FIBCD1	84929	broad.mit.edu	37	chr9	133780649	133780649	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ccggaatagtcagccacggtGagcgggtacccgtcttcctc	12	14	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr9:133780649G>C	uc004bzz.2	-	6	1343	c.1098C>G	c.(1096-1098)CTC>CTG	p.L366L	FIBCD1_uc011mcc.1_Silent_p.L366L	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	366	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CAGCCACGGTGAGCGGGTACC	0.657													0	0	0	0.038147	0	7	24										C	133780649	G	C	133780649	2	2	45	1	0	0	0	0	0	0	0	1	5884	1277	45	1		1	FIBCD1	9	133780649	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	14320326	133780649	7432782	128	11591										
VIM	7431	broad.mit.edu	37	chr10	17277345	17277345	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttaagatggcccttgacattGagattgccacctacaggaag	10	9	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:17277345G>C	uc001iou.2	+	7	1599	c.1186G>C	c.(1186-1188)GAG>CAG	p.E396Q	VIM_uc001iov.1_Missense_Mutation_p.E396Q|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.E396Q|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.E354Q|VIM_uc001ipc.1_Missense_Mutation_p.E396Q	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	396	Rod.|Coil 2.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						CCTTGACATTGAGATTGCCAC	0.458													0	0	0	0.11911	0	14	56										C	17277345	G	C	17277345	3	2	45	1	0	0	0	0	1	0	0	0	17163	1291	45	1	1208	1	VIM	10	17277345	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		17277345	118257402	129	11592										
NEBL	10529	broad.mit.edu	37	chr10	21117520	21117520	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	caggagtatctgctatggtaGaatagttagaaagcatcttc	10	6	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:21117520G>A	uc001iqi.2	-	17	2112	c.1715C>T	c.(1714-1716)TCT>TTT	p.S572F	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	572	Nebulin 16.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						TGCTATGGTAGAATAGTTAGA	0.338													0	0	0	0.080935	0	12	51										A	21117520	G	A	21117520	3	1	45	1	0	0	0	0	1	0	0	0	10303	942	33	1	1377	1	NEBL	10	21117520	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3840175	21117520	114417227	130	11593										
MASTL	84930	broad.mit.edu	37	chr10	27459817	27459817	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggtcctcctttggaggtgctGaaaacgttagcctctaaaag	11	9	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:27459817G>A	uc001itm.2	+	8	2568	c.1929G>A	c.(1927-1929)CTG>CTA	p.L643L	MASTL_uc001itl.2_Silent_p.L643L|MASTL_uc009xkw.1_Silent_p.L643L|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	643	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TGGAGGTGCTGAAAACGTTAG	0.398													0	0	0	0.108266	0	28	84										A	27459817	G	A	27459817	2	1	45	1	0	0	0	0	0	0	0	1	9328	1277	45	1		1	MASTL	10	27459817	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6342297	27459817	108074930	131	11594										
ARMC4	55130	broad.mit.edu	37	chr10	28273125	28273125	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	catcaaacctgaggtatattCaatagattccaagactgttt	6	8	2	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:28273125C>G	uc009xky.2	-	5	768	c.670G>C	c.(670-672)GAA>CAA	p.E224Q	ARMC4_uc010qds.1_5'Flank|ARMC4_uc010qdt.1_5'Flank|ARMC4_uc001itz.2_Missense_Mutation_p.E224Q|ARMC4_uc010qdu.1_5'Flank	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	224							binding			ovary(4)|skin(2)	6						GAGGTATATTCAATAGATTCC	0.328													0	0	0	0.069234	0	10	164										G	28273125	C	G	28273125	3	3	45	1	0	0	0	0	1	0	0	0	953	835	29	1	2528	1	ARMC4	10	28273125	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	813308	28273125	107261622	132	11595										
ANKRD30A	91074	broad.mit.edu	37	chr10	37478443	37478443	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atgtgtgtttacccaaggctAcgcatcaaaaagaaatagat	8	7	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:37478443A>G	uc001iza.1	+	25	2401	c.2302A>G	c.(2302-2304)ACG>GCG	p.T768A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	824						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ACCCAAGGCTACGCATCAAAA	0.289													0	0	0	0.115264	0	3	53										G	37478443	A	G	37478443	3	3	45	1	0	0	0	0	1	0	0	0	658	391	14	5	2400	5	ANKRD30A	10	37478443	Missense_Mutation	SNP	A	TCGA-DK-A1AB-01A-11D-A13W-08	9205318	37478443	98056304	133	11596										
ZNF485	220992	broad.mit.edu	37	chr10	44112076	44112076	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	attgaatgtgggaagttcctGaagaagcactcaacgtttat	10	6	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:44112076G>A	uc010qfc.1	+	5	779	c.585G>A	c.(583-585)CTG>CTA	p.L195L	ZNF485_uc010qfd.1_Silent_p.L104L	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	195	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAAGTTCCTGAAGAAGCACT	0.393													0	0	0	0.144211	0	31	90										A	44112076	G	A	44112076	2	1	45	1	0	0	0	0	0	0	0	1	17935	1277	45	1		1	ZNF485	10	44112076	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6633633	44112076	91422671	134	11597										
ARID5B	84159	broad.mit.edu	37	chr10	63852251	63852251	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gcagaacattggggcggcgcGgccgatcaagcgcagcctgg	17	12	1	1	rs137983907		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:63852251G>A	uc001jlt.1	+	10	3055	c.3029G>A	c.(3028-3030)CGG>CAG	p.R1010Q		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1010					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GGGGCGGCGCGGCCGATCAAG	0.567													0	0	0	0.116897	0	23	77										A	63852251	G	A	63852251	3	1	45	1	0	0	0	0	1	0	0	0	922	1116	39	2	3067	2	ARID5B	10	63852251	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	19740175	63852251	71682496	135	11598										
NDST2	8509	broad.mit.edu	37	chr10	75568098	75568098	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagcagcagtatgaggcggtGcagttccagctgccgagctg	15	11	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:75568098G>A	uc001jvk.2	-	3	853	c.49C>T	c.(49-51)CAC>TAC	p.H17Y	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Intron|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_5'Flank	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	17	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					ATGAGGCGGTGCAGTTCCAGC	0.622													0	0	0	0.115264	0	3	4										A	75568098	G	A	75568098	3	1	45	1	0	0	0	0	1	0	0	0	10256	1319	46	2	2654	2	NDST2	10	75568098	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	11715847	75568098	59966649	136	11599										
HTR7	3363	broad.mit.edu	37	chr10	92617282	92617282	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gggctggctgtcacctcgctCagcaggtgcggcgcccagga	16	14	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:92617282C>G	uc001kha.2	-	1	390	c.147G>C	c.(145-147)CTG>CTC	p.L49L	HTR7_uc001kgz.2_Silent_p.L49L|HTR7_uc001khb.2_Silent_p.L49L	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	49	Extracellular (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	TCACCTCGCTCAGCAGGTGCG	0.701													0	0	0	0.021553	0	6	11										G	92617282	C	G	92617282	2	3	45	1	0	0	0	0	0	0	0	1	7452	813	29	1		1	HTR7	10	92617282	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	17049184	92617282	42917465	137	11600										
CCDC147	159686	broad.mit.edu	37	chr10	106209909	106209909	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagaaacttaccaatgagctCcagaatttaaagaagaaata	7	6	0	5			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:106209909C>G	uc001kyh.2	+	17	2591	c.2457C>G	c.(2455-2457)CTC>CTG	p.L819L		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	819	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		CCAATGAGCTCCAGAATTTAA	0.328													0	0	0	0.139131	0	53	127										G	106209909	C	G	106209909	2	3	45	1	0	0	0	0	0	0	0	1	2781	842	30	1		1	CCDC147	10	106209909	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	13592627	106209909	29324838	138	11601										
ATE1	11101	broad.mit.edu	37	chr10	123673374	123673374	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttttttcaaaaccttcttgtGagattttgaaggctgaaatt	7	5	2	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr10:123673374G>C	uc001lfp.2	-	4	350	c.268C>G	c.(268-270)CAC>GAC	p.H90D	ATE1_uc001lfq.2_Missense_Mutation_p.H90D|ATE1_uc010qtr.1_Intron|ATE1_uc010qts.1_5'UTR|ATE1_uc010qtt.1_Missense_Mutation_p.H83D|ATE1_uc001lfr.2_5'UTR|ATE1_uc009xzu.2_Intron	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2	90					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				ACCTTCTTGTGAGATTTTGAA	0.363													0	0	0	0.049695	0	21	46										C	123673374	G	C	123673374	3	2	45	1	0	0	0	0	1	0	0	0	1078	1290	45	1	1457	1	ATE1	10	123673374	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	17463465	123673374	11861373	139	11602										
NAV2	89797	broad.mit.edu	37	chr11	19955347	19955347	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aggctggacctcaaggaggaGccaaaagaagaccccagtgg	14	10	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:19955347G>A	uc010rdm.1	+	8	1987	c.1626G>A	c.(1624-1626)GAG>GAA	p.E542E	NAV2_uc001mpp.2_Silent_p.E455E|NAV2_uc001mpr.3_Silent_p.E519E	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	542						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TCAAGGAGGAGCCAAAAGAAG	0.423													0	0	0	0.076483	0	23	32										A	19955347	G	A	19955347	2	1	45	1	0	0	0	0	0	0	0	1	10184	962	34	2		2	NAV2	11	19955347	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		19955347	115051169	140	11603										
OR5W2	390148	broad.mit.edu	37	chr11	55681643	55681643	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcaagagtagatagcacactCtgctagacatgttgactgta	9	8	2	4	rs12786096		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:55681643C>G	uc010rir.1	-	1	416	c.416G>C	c.(415-417)AGA>ACA	p.R139T		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATAGCACACTCTGCTAGACAT	0.468													0	0	0	0.043863	0	20	46										G	55681643	C	G	55681643	3	3	45	1	0	0	0	0	1	0	0	0	11185	913	32	1	518	1	OR5W2	11	55681643	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	35726296	55681643	79324873	141	11604										
OR4D10	390197	broad.mit.edu	37	chr11	59245789	59245789	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gaggaaccatgagatgaagtCagccatgaggagactgaaga	14	6	1	6			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:59245789C>G	uc001nnz.1	+	1	887	c.887C>G	c.(886-888)TCA>TGA	p.S296*		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GAGATGAAGTCAGCCATGAGG	0.368													0	0	0	0.047766	0	9	31										G	59245789	C	G	59245789	4	3	45	1	0	0	0	0	0	1	0	0	11054	838	29	1	889	1	OR4D10	11	59245789	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	3564146	59245789	75760727	142	11605										
C11orf66	220004	broad.mit.edu	37	chr11	61254053	61254053	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcgggaaacagccttcagcCgagggaatgaaaggattctg	14	8	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:61254053C>T	uc001nru.1	+	9	930	c.805C>T	c.(805-807)CGA>TGA	p.R269*	C11orf66_uc009ynq.1_Nonsense_Mutation_p.R249*	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	269										ovary(1)	1						AGCCTTCAGCCGAGGGAATGA	0.577													0	0	0	0.014758	0	4	14										T	61254053	C	T	61254053	4	4	45	1	0	0	0	0	0	1	0	0	1656	644	23	2	835	2	C11orf66	11	61254053	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	2008264	61254053	73752463	143	11606										
POLA2	23649	broad.mit.edu	37	chr11	65034149	65034149	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acataaagttggccttacctCagagatcctgaactcttttg	7	10	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:65034149C>T	uc001odj.2	+	2	518	c.176C>T	c.(175-177)TCA>TTA	p.S59L	POLA2_uc009yqf.1_Missense_Mutation_p.S59L|POLA2_uc010rod.1_Intron	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	59					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	GGCCTTACCTCAGAGATCCTG	0.383													0	0	0	0.038395	0	18	25										T	65034149	C	T	65034149	3	4	45	1	0	0	0	0	1	0	0	0	12188	838	29	1	182	1	POLA2	11	65034149	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	3780096	65034149	69972367	144	11607										
FGF3	2248	broad.mit.edu	37	chr11	69625371	69625371	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgggctgccggcgggccccaGgcgtactagacaccgtccgg	16	15	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:69625371G>C	uc001oph.2	-	3	913	c.422C>G	c.(421-423)CCT>CGT	p.P141R		NM_005247	NP_005238	P11487	FGF3_HUMAN	fibroblast growth factor 3 precursor	141					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			GCGGGCCCCAGGCGTACTAGA	0.657													0	0	0	0.105934	0	14	9										C	69625371	G	C	69625371	3	2	45	1	0	0	0	0	1	0	0	0	5853	1000	35	4	301	4	FGF3	11	69625371	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	4591222	69625371	65381145	145	11608										
SHANK2	22941	broad.mit.edu	37	chr11	70507825	70507825	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagcgaccattattgtagccCgtcatcatcaccgcggccgc	9	16	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:70507825C>T	uc010rqn.1	-	1	99	c.48G>A	c.(46-48)ACG>ACA	p.T16T	SHANK2_uc001opz.2_Silent_p.T16T|SHANK2_uc001oqc.2_Intron|uc009ysn.1_Missense_Mutation_p.P88L|SHANK2_uc010rqp.1_Silent_p.T16T	NM_133266	NP_573573	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	Error:Variant_position_missing_in_Q9UPX8_after_alignment					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TATTGTAGCCCGTCATCATCA	0.542													0	0	0	0.134883	0	28	96										T	70507825	C	T	70507825	2	4	45	1	0	0	0	0	0	0	0	1	14265	639	23	2		2	SHANK2	11	70507825	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	882454	70507825	64498691	146	11609										
CLPB	81570	broad.mit.edu	37	chr11	72145375	72145375	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cgccccccggtggctaccctCagccactgcggctccccgag	11	21	1	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr11:72145375C>G	uc001osj.2	-	1	194	c.144G>C	c.(142-144)CTG>CTC	p.L48L	CLPB_uc010rqx.1_5'UTR|CLPB_uc010rqy.1_Silent_p.L48L|CLPB_uc001osk.2_Silent_p.L48L|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_5'UTR	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	48					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						TGGCTACCCTCAGCCACTGCG	0.692											OREG0021194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.132662	0	13	9										G	72145375	C	G	72145375	2	3	45	1	0	0	0	0	0	0	0	1	3551	813	29	1		1	CLPB	11	72145375	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1637550	72145375	62861141	147	11610										
RAD52	5893	broad.mit.edu	37	chr12	1025522	1025522	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcgctcaccctcactcttctCagctgacggcgtggagactc	9	16	4	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:1025522C>G	uc001qis.1	-	9	967	c.853G>C	c.(853-855)GAG>CAG	p.E285Q	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.E208Q|RAD52_uc001qiu.1_Missense_Mutation_p.E285Q|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Nonstop_Mutation_p.*302S	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	285					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			TCACTCTTCTCAGCTGACGGC	0.428								Homologous_recombination					0	0	0	0.009096	0	4	10										G	1025522	C	G	1025522	3	3	45	1	0	0	0	0	1	0	0	0	12991	835	29	1	419	1	RAD52	12	1025522	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		1025522	132826373	148	11611										
C12orf11	55726	broad.mit.edu	37	chr12	27067369	27067369	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgttaaaaatggtggtttgtGaaatgatcataggccagtaa	11	3	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:27067369G>T	uc001rhk.3	-	12	1928	c.1391C>A	c.(1390-1392)TCA>TAA	p.S464*	C12orf11_uc001rhj.3_Intron|C12orf11_uc010sjk.1_Nonsense_Mutation_p.S363*	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	464					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					GGTGGTTTGTGAAATGATCAT	0.343													1	0	1.75199e-13	0.125774	1.95485e-13	27	101										T	27067369	G	T	27067369	4	4	45	1	0	0	0	0	0	1	0	0	1675	1294	45	3	753	3	C12orf11	12	27067369	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	26041847	27067369	106784526	149	11612										
ARNTL2	56938	broad.mit.edu	37	chr12	27573406	27573406	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgcatttatgaattacttaGaagcagaggggggcctggga	14	6	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:27573406G>T	uc001rht.1	+	17	1870	c.1852G>T	c.(1852-1854)GAA>TAA	p.E618*	ARNTL2_uc001rhw.2_Nonsense_Mutation_p.E581*|ARNTL2_uc010sjp.1_3'UTR|ARNTL2_uc001rhu.1_Nonsense_Mutation_p.E604*|ARNTL2_uc009zji.1_Nonsense_Mutation_p.E584*|ARNTL2_uc001rhv.1_Nonsense_Mutation_p.E570*|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	618					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					GAATTACTTAGAAGCAGAGGG	0.448													1	0	1.67942e-08	0.038395	1.86082e-08	19	130										T	27573406	G	T	27573406	4	4	45	1	0	0	0	0	0	1	0	0	968	943	33	3	1918	3	ARNTL2	12	27573406	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	506037	27573406	106278489	150	11613										
IPO8	10526	broad.mit.edu	37	chr12	30833508	30833508	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagctgaacaatttgttgctGaatacgaggcaggaatatct	11	6	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:30833508G>A	uc001rjd.2	-	5	717	c.547C>T	c.(547-549)CAG>TAG	p.Q183*		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	183					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					ATTTGTTGCTGAATACGAGGC	0.343													0	0	0	0.139131	0	71	140										A	30833508	G	A	30833508	4	1	45	1	0	0	0	0	0	1	0	0	7798	1299	45	1	2650	1	IPO8	12	30833508	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3260102	30833508	103018387	151	11614										
C12orf35	55196	broad.mit.edu	37	chr12	32137616	32137616	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ataatccaaagactcctccaGatgggaaaagtcattttcct	6	10	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:32137616G>A	uc001rks.2	+	4	4141	c.3727G>A	c.(3727-3729)GAT>AAT	p.D1243N	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1243										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			GACTCCTCCAGATGGGAAAAG	0.368													0	0	0	0.083992	0	25	57										A	32137616	G	A	32137616	3	1	45	1	0	0	0	0	1	0	0	0	1682	942	33	1	3729	1	C12orf35	12	32137616	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	1304108	32137616	101714279	152	11615										
DDX23	9416	broad.mit.edu	37	chr12	49230568	49230568	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccttcttacgaagtttgcgGagtcttgccctggagcaggg	13	10	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:49230568G>A	uc001rsm.2	-	10	1111	c.1020C>T	c.(1018-1020)CTC>CTT	p.L340L		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	340						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						GAAGTTTGCGGAGTCTTGCCC	0.537													0	0	0	0.139131	0	110	285										A	49230568	G	A	49230568	2	1	45	1	0	0	0	0	0	0	0	1	4350	1161	41	1		1	DDX23	12	49230568	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	17092952	49230568	84621327	153	11616										
TROAP	10024	broad.mit.edu	37	chr12	49722719	49722719	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cttcttcacaggacagccatGactcccacctgatgccctcc	6	18	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:49722719G>A	uc001rtx.3	+	9	1068	c.901G>A	c.(901-903)GAC>AAC	p.D301N	TROAP_uc009zlh.2_Missense_Mutation_p.D301N|TROAP_uc001rty.2_Missense_Mutation_p.D9N	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	301					cell adhesion	cytoplasm				ovary(1)	1						GGACAGCCATGACTCCCACCT	0.468													0	0	0	0.049695	0	20	49										A	49722719	G	A	49722719	3	1	45	1	0	0	0	0	1	0	0	0	16572	1290	45	1	1033	1	TROAP	12	49722719	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	492151	49722719	84129176	154	11617										
GALNT6	11226	broad.mit.edu	37	chr12	51759233	51759233	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagtgggcatccaggaacgtGagcacctccgcctgtgccac	12	15	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:51759233G>A	uc001ryk.2	-	4	1020	c.795C>T	c.(793-795)CTC>CTT	p.L265L	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.L265L	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	265	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						CCAGGAACGTGAGCACCTCCG	0.677													0	0	0	0.105934	0	13	29										A	51759233	G	A	51759233	2	1	45	1	0	0	0	0	0	0	0	1	6217	1277	45	1		1	GALNT6	12	51759233	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2036514	51759233	82092662	155	11618										
LRP1	4035	broad.mit.edu	37	chr12	57595667	57595667	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atgactgtggggatggctcgGatgagcccaaggaagagtgt	17	6	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:57595667G>C	uc001snd.2	+	67	11039	c.10573G>C	c.(10573-10575)GAT>CAT	p.D3525H		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3525	Extracellular (Potential).|LDL-receptor class A 25.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGATGGCTCGGATGAGCCCAA	0.632													0	0	0	0.11911	0	14	49										C	57595667	G	C	57595667	3	2	45	1	0	0	0	0	1	0	0	0	8951	1174	41	1	10839	1	LRP1	12	57595667	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	5836434	57595667	76256228	156	11619										
TBC1D15	64786	broad.mit.edu	37	chr12	72291701	72291701	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gaaaagaaattcgaggttaaGagattatagaagtcttatcg	10	3	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:72291701G>A	uc001swu.2	+	11	1289	c.1280G>A	c.(1279-1281)AGA>AAA	p.R427K	TBC1D15_uc009zrv.2_Missense_Mutation_p.R289K|TBC1D15_uc010stt.1_Missense_Mutation_p.R396K|TBC1D15_uc001swv.2_Missense_Mutation_p.R410K|TBC1D15_uc001sww.2_Missense_Mutation_p.R159K	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	405	Rab-GAP TBC.						protein binding|Rab GTPase activator activity				0						TCGAGGTTAAGAGATTATAGA	0.333													0	0	0	0.099896	0	28	71										A	72291701	G	A	72291701	3	1	45	1	0	0	0	0	1	0	0	0	15601	942	33	1	1380	1	TBC1D15	12	72291701	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	14696034	72291701	61560194	157	11620										
C12orf51	283450	broad.mit.edu	37	chr12	112664513	112664513	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tggacattgttgtatgaattCttcacaaaataagctgtctt	7	6	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr12:112664513C>G	uc009zwc.2	-	37	5656	c.5638G>C	c.(5638-5640)GAA>CAA	p.E1880Q	C12orf51_uc001ttr.1_Missense_Mutation_p.E55Q	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TGTATGAATTCTTCACAAAAT	0.398													0	0	0	0.080935	0	12	26										G	112664513	C	G	112664513	3	3	45	1	0	0	0	0	1	0	0	0	1696	922	32	1	6484	1	C12orf51	12	112664513	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	40372812	112664513	21187382	158	11621										
IFT88	8100	broad.mit.edu	37	chr13	21157156	21157156	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctagtcatggcagaagacctCcagtaagtgaaaaaaatttt	8	7	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr13:21157156C>T	uc001unh.2	+	5	574	c.178C>T	c.(178-180)CCA>TCA	p.P60S	IFT88_uc001uni.2_Missense_Mutation_p.P51S|IFT88_uc001unj.2_Missense_Mutation_p.P50S|IFT88_uc010tcq.1_Missense_Mutation_p.P50S	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	60					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CAGAAGACCTCCAGTAAGTGA	0.219													0	0	0	0.043863	0	20	68										T	21157156	C	T	21157156	3	4	45	1	0	0	0	0	1	0	0	0	7566	855	30	1	188	1	IFT88	13	21157156	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		21157156	94012722	159	11622										
UGGT2	55757	broad.mit.edu	37	chr13	96513055	96513055	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tacctaccttaaaaaacgttCatataaatgaccagaagcaa	4	9	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr13:96513055C>T	uc001vmt.2	-	32	3897	c.3727G>A	c.(3727-3729)GAA>AAA	p.E1243K		NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1243	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						AAAAAACGTTCATATAAATGA	0.254													0	0	0	0.105934	0	13	65										T	96513055	C	T	96513055	3	4	45	1	0	0	0	0	1	0	0	0	16939	835	29	1	855	1	UGGT2	13	96513055	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	75355899	96513055	18656823	160	11623										
ATP11A	23250	broad.mit.edu	37	chr13	113532599	113532599	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tctcagacttccagcagcctGagtttctgatggaacaaggt	10	10	2	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr13:113532599G>C	uc001vsi.3	+	29	3484	c.3396G>C	c.(3394-3396)CTG>CTC	p.L1132L	ATP11A_uc001vsj.3_Intron|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1132	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CCAGCAGCCTGAGTTTCTGAT	0.572													0	0	0	0.038395	0	17	47										C	113532599	G	C	113532599	2	2	45	1	0	0	0	0	0	0	0	1	1119	1277	45	1		1	ATP11A	13	113532599	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	17019544	113532599	1637279	161	11624										
TRAPPC6B	122553	broad.mit.edu	37	chr14	39627491	39627491	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cttaattaatttaattacctGatgatttgtccttagattgt	5	5	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:39627491G>A	uc001wut.1	-	3	600	c.265C>T	c.(265-267)CAG>TAG	p.Q89*	TRAPPC6B_uc001wuu.1_Nonsense_Mutation_p.Q89*|TRAPPC6B_uc001wuv.1_RNA|TRAPPC6B_uc010tqd.1_Intron	NM_001079537	NP_001073005	Q86SZ2	TPC6B_HUMAN	trafficking protein particle complex 6B isoform	89					vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0128)		TTAATTACCTGATGATTTGTC	0.274													0	0	0	0.047766	0	7	42										A	39627491	G	A	39627491	4	1	45	1	0	0	0	0	0	1	0	0	16461	1299	45	1	227	1	TRAPPC6B	14	39627491	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		39627491	67722049	162	11625										
CTAGE5	4253	broad.mit.edu	37	chr14	39783995	39783995	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agagaactattcattcttatCaagggcaggtatatatatat	7	5	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:39783995C>T	uc001wvg.3	+	15	1684	c.1348C>T	c.(1348-1350)CAA>TAA	p.Q450*	CTAGE5_uc010tqe.1_Nonsense_Mutation_p.Q412*|CTAGE5_uc001wuz.3_Nonsense_Mutation_p.Q438*|CTAGE5_uc001wuy.3_Nonsense_Mutation_p.Q370*|CTAGE5_uc001wvb.3_Nonsense_Mutation_p.Q421*|CTAGE5_uc001wvc.3_Nonsense_Mutation_p.Q395*|CTAGE5_uc001wva.3_Nonsense_Mutation_p.Q421*|CTAGE5_uc001wvh.3_Nonsense_Mutation_p.Q450*|CTAGE5_uc001wvf.3_Nonsense_Mutation_p.Q375*|CTAGE5_uc001wvi.3_Nonsense_Mutation_p.Q455*|CTAGE5_uc010amz.2_Nonsense_Mutation_p.Q66*|CTAGE5_uc001wvj.3_Nonsense_Mutation_p.Q421*	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	450	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TCATTCTTATCAAGGGCAGGT	0.229													0	0	0	0.049695	0	19	53										T	39783995	C	T	39783995	4	4	45	1	0	0	0	0	0	1	0	0	3994	827	29	1	1437	1	CTAGE5	14	39783995	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	156504	39783995	67565545	163	11626										
PPIL5	122769	broad.mit.edu	37	chr14	50074213	50074213	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtttcaacgctcacaccagtGaagacttcagaatttgaaaa	7	9	3	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:50074213G>A	uc001wwn.2	+	3	702	c.378G>A	c.(376-378)GTG>GTA	p.V126V	SDCCAG1_uc010anj.1_Intron|PPIL5_uc001wwo.2_Intron|PPIL5_uc010ank.2_Silent_p.V67V|PPIL5_uc001wwp.2_RNA	NM_152329	NP_689542	Q96L50	LLR1_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 5	126											0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TCACACCAGTGAAGACTTCAG	0.368													0	0	0	0.125774	0	31	95										A	50074213	G	A	50074213	2	1	45	1	0	0	0	0	0	0	0	1	12330	1277	45	1		1	PPIL5	14	50074213	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	10290218	50074213	57275327	164	11627										
SDCCAG1	9147	broad.mit.edu	37	chr14	50255908	50255908	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcaaagtcttgtaactcatGagttataacctcaaggaacg	8	8	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:50255908G>A	uc001wxc.2	-	28	2919	c.2851C>T	c.(2851-2853)CAT>TAT	p.H951Y	SDCCAG1_uc010anj.1_Missense_Mutation_p.H951Y|SDCCAG1_uc001wwz.2_Missense_Mutation_p.H151Y|SDCCAG1_uc001wxa.2_Missense_Mutation_p.H231Y|SDCCAG1_uc010tqi.1_Missense_Mutation_p.H930Y|SDCCAG1_uc001wxe.2_Missense_Mutation_p.H909Y	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	951						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		TGTAACTCATGAGTTATAACC	0.428													0	0	0	0.139131	0	53	169										A	50255908	G	A	50255908	3	1	45	1	0	0	0	0	1	0	0	0	13957	1290	45	1	403	1	SDCCAG1	14	50255908	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	181695	50255908	57093632	165	11628										
C14orf182	283551	broad.mit.edu	37	chr14	50472344	50472344	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagggatgggccccgctactGagtggcaagaagacgaaatg	16	8	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:50472344G>C	uc001wxi.1	-	1	1895	c.174C>G	c.(172-174)CTC>CTG	p.L58L		NM_001012706	NP_001012724	A1A4T8	CN182_HUMAN	hypothetical protein LOC283551	58											0						CCCCGCTACTGAGTGGCAAGA	0.522													0	0	0	0.09836	0	42	151										C	50472344	G	C	50472344	2	2	45	1	0	0	0	0	0	0	0	1	1765	1277	45	1		1	C14orf182	14	50472344	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	216436	50472344	56877196	166	11629										
ESR2	2100	broad.mit.edu	37	chr14	64727309	64727309	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggctcagcctccaggagggtGagcactagctgctcggggct	16	12	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:64727309G>A	uc001xha.1	-	5	1278	c.810C>T	c.(808-810)CTC>CTT	p.L270L	ESR2_uc001xgu.2_Silent_p.L270L|ESR2_uc001xgv.2_Silent_p.L270L|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Silent_p.L270L|ESR2_uc001xgy.1_Silent_p.L270L|ESR2_uc001xgz.1_Silent_p.L270L|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Silent_p.L270L|ESR2_uc010aqd.1_RNA	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	270	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	CCAGGAGGGTGAGCACTAGCT	0.677													0	0	0	0.055883	0	21	30										A	64727309	G	A	64727309	2	1	45	1	0	0	0	0	0	0	0	1	5257	1277	45	1		1	ESR2	14	64727309	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	14254965	64727309	42622231	167	11630										
PLEKHG3	26030	broad.mit.edu	37	chr14	65194411	65194411	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gcggccggtgagcctgacctCtaccacctcctcgtcgggct	12	17	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:65194411C>G	uc001xho.1	+	2	331	c.62C>G	c.(61-63)TCT>TGT	p.S21C	PLEKHG3_uc001xhn.1_Missense_Mutation_p.S21C|PLEKHG3_uc001xhp.2_Missense_Mutation_p.S21C|PLEKHG3_uc010aqh.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	21	Ser-rich.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		AGCCTGACCTCTACCACCTCC	0.667													0	0	0	0.014758	0	3	10										G	65194411	C	G	65194411	3	3	45	1	0	0	0	0	1	0	0	0	12070	913	32	1	64	1	PLEKHG3	14	65194411	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	467102	65194411	42155129	168	11631										
ZDHHC22	283576	broad.mit.edu	37	chr14	77605820	77605820	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggtgctaggtgaggggcatgGagtcttcctggccgaggccc	18	10	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:77605820G>C	uc010asp.2	-	2	465	c.262C>G	c.(262-264)CCA>GCA	p.P88A		NM_174976	NP_777636	Q8N966	ZDH22_HUMAN	zinc finger, DHHC domain containing 22	88	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		GAGGGGCATGGAGTCTTCCTG	0.627													0	0	0	0.014758	0	5	9										C	77605820	G	C	77605820	3	2	45	1	0	0	0	0	1	0	0	0	17610	1174	41	1	537	1	ZDHHC22	14	77605820	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	12411409	77605820	29743720	169	11632										
EML5	161436	broad.mit.edu	37	chr14	89168814	89168814	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cctgttgccacgtagtctttCaaaggatgaatagttaggca	10	8	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:89168814C>G	uc001xxg.2	-	15	2400	c.2214G>C	c.(2212-2214)TTG>TTC	p.L738F	EML5_uc001xxh.1_5'UTR	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	738	WD 11.					cytoplasm|microtubule				ovary(3)	3						CGTAGTCTTTCAAAGGATGAA	0.388													0	0	0	0.02938	0	7	53										G	89168814	C	G	89168814	3	3	45	1	0	0	0	0	1	0	0	0	5100	825	29	1	3839	1	EML5	14	89168814	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	11562994	89168814	18180726	170	11633										
CATSPERB	79820	broad.mit.edu	37	chr14	92088132	92088132	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	taagaaccatgtgctctttaGaaaggtcatattgttgggtg	11	5	2	2	rs143009010		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:92088132G>C	uc001xzs.1	-	19	2220	c.2080C>G	c.(2080-2082)CTA>GTA	p.L694V	CATSPERB_uc010aub.1_Missense_Mutation_p.L216V	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	694					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GTGCTCTTTAGAAAGGTCATA	0.383													0	0	0	0.139131	0	51	137										C	92088132	G	C	92088132	3	2	45	1	0	0	0	0	1	0	0	0	2691	933	33	1	1306	1	CATSPERB	14	92088132	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2919318	92088132	15261408	171	11634										
ATG2B	55102	broad.mit.edu	37	chr14	96752292	96752292	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgttctcgagccgcagtttCataaatggtctgagccgtgt	12	9	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:96752292C>T	uc001yfi.2	-	42	6402	c.6037G>A	c.(6037-6039)GAA>AAA	p.E2013K		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	2013										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GCCGCAGTTTCATAAATGGTC	0.557													0	0	0	0.069234	0	6	16										T	96752292	C	T	96752292	3	4	45	1	0	0	0	0	1	0	0	0	1094	835	29	1	203	1	ATG2B	14	96752292	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4664160	96752292	10597248	172	11635										
EVL	51466	broad.mit.edu	37	chr14	100607527	100607527	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tctctcccaggatgaagcctGctgggagcgtgaatgacatg	13	10	1	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:100607527G>A	uc001ygt.2	+	12	1338	c.1099G>A	c.(1099-1101)GCT>ACT	p.A367T	EVL_uc001ygu.2_Missense_Mutation_p.A369T|EVL_uc010avu.2_Missense_Mutation_p.A226T|EVL_uc001ygw.1_5'Flank	NM_016337	NP_057421	Q9UI08	EVL_HUMAN	Enah/Vasp-like	367	EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding			large_intestine(2)|ovary(1)	3		Melanoma(154;0.152)				GATGAAGCCTGCTGGGAGCGT	0.647													0	0	0	0.02938	0	7	38										A	100607527	G	A	100607527	3	1	45	1	0	0	0	0	1	0	0	0	5291	1319	46	2	1151	2	EVL	14	100607527	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3855235	100607527	6742013	173	11636										
DYNC1H1	1778	broad.mit.edu	37	chr14	102442048	102442048	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tatatttattatgatttgtaGaggacgtcggtgatgaagga	12	2	0	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:102442048G>C	uc001yks.2	+	2	421	c.257_splice	c.e2-1	p.E86_splice		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1						cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ATGATTTGTAGAGGACGTCGG	0.323													0	0	0	0.009096	0	3	76										C	102442048	G	C	102442048	5	2	45	1	0	0	0	0	0	0	1	0	4841	956	33	1	262	1	DYNC1H1	14	102442048	Splice_Site	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	1834521	102442048	4907492	174	11637										
INF2	64423	broad.mit.edu	37	chr14	105181636	105181636	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcagaggttccccctgattCtgatgataataaaacaaaga	8	8	1	5			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:105181636C>T	uc001ypb.2	+	22	3853	c.3710C>T	c.(3709-3711)TCT>TTT	p.S1237F	INF2_uc010tyi.1_Missense_Mutation_p.S1237F|INF2_uc001ypc.2_Intron|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	1237					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CCCCCTGATTCTGATGATAAT	0.557													0	0	0	0.139131	0	48	132										T	105181636	C	T	105181636	3	4	45	1	0	0	0	0	1	0	0	0	7734	913	32	1	3796	1	INF2	14	105181636	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	2739588	105181636	2167904	175	11638										
AHNAK2	113146	broad.mit.edu	37	chr14	105410194	105410194	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggagtttcatgtccacctggCgagcttggaccgtcaggtcg	14	11	2	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr14:105410194C>T	uc010axc.1	-	7	11714	c.11594G>A	c.(11593-11595)CGC>CAC	p.R3865H	AHNAK2_uc001ypx.2_Missense_Mutation_p.R3765H	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3865						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GTCCACCTGGCGAGCTTGGAC	0.607													0	0	0	0.139131	0	63	154										T	105410194	C	T	105410194	3	4	45	1	0	0	0	0	1	0	0	0	415	768	27	2	5797	2	AHNAK2	14	105410194	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	228558	105410194	1939346	176	11639										
CYFIP1	23191	broad.mit.edu	37	chr15	22933811	22933811	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcctggcagatattgtgaatCtgtgtgtggattactacgag	12	6	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:22933811C>T	uc001yus.2	+	8	834	c.730C>T	c.(730-732)CTG>TTG	p.L244L	CYFIP1_uc001yut.2_Silent_p.L244L|CYFIP1_uc010aya.1_Silent_p.L272L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	244					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TATTGTGAATCTGTGTGTGGA	0.522													0	0	0	0.069456	0	33	148										T	22933811	C	T	22933811	2	4	45	1	0	0	0	0	0	0	0	1	4137	912	32	1		1	CYFIP1	15	22933811	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		22933811	79597581	177	11640										
APBA2	321	broad.mit.edu	37	chr15	29393870	29393870	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	attgggaacattgtagtgctGatggccagacgccgcatgcc	13	10	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:29393870G>A	uc001zck.2	+	9	1614	c.1407G>A	c.(1405-1407)CTG>CTA	p.L469L	APBA2_uc010azj.2_Silent_p.L457L|APBA2_uc010uat.1_Silent_p.L457L|APBA2_uc001zcl.2_Silent_p.L457L|APBA2_uc001zcm.1_Silent_p.L161L	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	469	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TTGTAGTGCTGATGGCCAGAC	0.592													0	0	0	0.014758	0	4	18										A	29393870	G	A	29393870	2	1	45	1	0	0	0	0	0	0	0	1	757	1277	45	1		1	APBA2	15	29393870	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6460059	29393870	73137522	178	11641										
RYR3	6263	broad.mit.edu	37	chr15	34047305	34047305	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctggatgcctcctccatggaGaagaggtttgcctataagtt	11	9	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:34047305G>C	uc001zhi.2	+	58	8509	c.8439G>C	c.(8437-8439)GAG>GAC	p.E2813D	RYR3_uc010bar.2_Missense_Mutation_p.E2813D	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2813	4.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCTCCATGGAGAAGAGGTTTG	0.443													0	0	0	0.014758	0	4	20										C	34047305	G	C	34047305	3	2	45	1	0	0	0	0	1	0	0	0	13770	933	33	1	8669	1	RYR3	15	34047305	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	4653435	34047305	68484087	179	11642										
CATSPER2	117155	broad.mit.edu	37	chr15	43932621	43932621	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atctccaggatgaaaataagCaagataaaccaagctgccac	7	10	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:43932621C>T	uc001zsh.2	-	5	677	c.462G>A	c.(460-462)TTG>TTA	p.L154L	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.L154L|CATSPER2_uc001zsj.2_Silent_p.L154L|CATSPER2_uc001zsk.2_Silent_p.L154L	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	154	Helical; Name=Segment S2; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGAAAATAAGCAAGATAAACC	0.418													0	0	0	0.092188	0	43	97										T	43932621	C	T	43932621	2	4	45	1	0	0	0	0	0	0	0	1	2688	709	25	2		2	CATSPER2	15	43932621	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	9885316	43932621	58598771	180	11643										
ATP8B4	79895	broad.mit.edu	37	chr15	50152570	50152570	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctctccatagccttcttggtGagcaaaagcatagccagacc	8	13	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:50152570G>A	uc001zxu.2	-	28	3542	c.3400C>T	c.(3400-3402)CAC>TAC	p.H1134Y	ATP8B4_uc010ber.2_Missense_Mutation_p.H1007Y|ATP8B4_uc010ufd.1_Missense_Mutation_p.H944Y|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Missense_Mutation_p.H137Y	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1134	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CCTTCTTGGTGAGCAAAAGCA	0.507													0	0	0	0.139131	0	50	115										A	50152570	G	A	50152570	3	1	45	1	0	0	0	0	1	0	0	0	1197	1290	45	1	182	1	ATP8B4	15	50152570	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6219949	50152570	52378822	181	11644										
TCF12	6938	broad.mit.edu	37	chr15	57565418	57565418	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	caaaactccttattcttcatCaagccgtggcagtcatcctt	5	13	4	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:57565418C>G	uc002aec.2	+	18	2148	c.1864C>G	c.(1864-1866)CAA>GAA	p.Q622E	TCF12_uc010ugm.1_Missense_Mutation_p.Q674E|TCF12_uc010ugn.1_Missense_Mutation_p.Q642E|TCF12_uc002aea.2_Missense_Mutation_p.Q646E|TCF12_uc010bfs.2_Missense_Mutation_p.Q43E|TCF12_uc002aeb.2_Missense_Mutation_p.Q646E|TCF12_uc002aed.2_Missense_Mutation_p.Q622E|TCF12_uc002aee.2_Missense_Mutation_p.Q452E|TCF12_uc010bft.2_Missense_Mutation_p.Q476E|TCF12_uc010ugo.1_Missense_Mutation_p.Q386E|TCF12_uc010ugp.1_Missense_Mutation_p.Q279E|TCF12_uc010ugq.1_Missense_Mutation_p.Q256E|TCF12_uc010ugr.1_Missense_Mutation_p.Q235E	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	622	Helix-loop-helix motif.				immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		TATTCTTCATCAAGCCGTGGC	0.448			T	TEC	extraskeletal myxoid chondrosarcoma								0	0	0	0.080935	0	11	40										G	57565418	C	G	57565418	3	3	45	1	0	0	0	0	1	0	0	0	15684	827	29	1	2079	1	TCF12	15	57565418	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	7412848	57565418	44965974	182	11645										
FAM96A	84191	broad.mit.edu	37	chr15	64385901	64385901	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgccgggcagctcccggctCagagaggccggagagccaca	15	15	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:64385901C>T	uc002amt.1	-	1	307	c.67G>A	c.(67-69)GAG>AAG	p.E23K	FAM96A_uc002amu.1_Missense_Mutation_p.E23K|FAM96A_uc010uin.1_Missense_Mutation_p.E23K|SNX1_uc010bgv.2_5'Flank|SNX1_uc010uio.1_5'Flank|SNX1_uc002amv.2_5'Flank|SNX1_uc002amw.2_5'Flank|SNX1_uc002amx.2_5'Flank|SNX1_uc002amy.2_5'Flank|SNX1_uc010bgw.2_5'Flank	NM_032231	NP_115607	Q9H5X1	FA96A_HUMAN	family with sequence similarity 96, member A	23					chromosome segregation						0						GCTCCCGGCTCAGAGAGGCCG	0.582													0	0	0	0.058154	0	8	27										T	64385901	C	T	64385901	3	4	45	1	0	0	0	0	1	0	0	0	5654	835	29	1	435	1	FAM96A	15	64385901	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	6820483	64385901	38145491	183	11646										
ITGA11	22801	broad.mit.edu	37	chr15	68620499	68620499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcagaggaaggcggccaggCaggtggcatccctgccactg	16	12	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr15:68620499C>A	uc002ari.2	-	16	2090	c.2003G>T	c.(2002-2004)TGC>TTC	p.C668F	ITGA11_uc010bib.2_Missense_Mutation_p.C668F	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	668	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GGCGGCCAGGCAGGTGGCATC	0.577													1	0	1.26484e-09	0.038147	1.40637e-09	6	38										A	68620499	C	A	68620499	3	1	45	1	0	0	0	0	1	0	0	0	7874	710	25	4	1623	4	ITGA11	15	68620499	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4234598	68620499	33910893	184	11647										
RNPS1	10921	broad.mit.edu	37	chr16	2312402	2312402	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtcaatcattttaattttccCataggtggaaaatatctcca	5	8	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:2312402C>T	uc002cpt.2	-	6	1099	c.553G>A	c.(553-555)GGG>AGG	p.G185R	RNPS1_uc002cpu.2_Missense_Mutation_p.G185R|RNPS1_uc002cpv.2_Missense_Mutation_p.G8R|RNPS1_uc002cpw.2_Missense_Mutation_p.G185R|RNPS1_uc002cpx.2_Missense_Mutation_p.G162R|RNPS1_uc010uwa.1_RNA	NM_080594	NP_542161	Q15287	RNPS1_HUMAN	RNA-binding protein S1, serine-rich domain	185	Necessary for interaction with PNN and exon-skipping.|Necessary for interaction with the cleaved p110 isoform of CDC2L1.|RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(1)	1						TTAATTTTCCCATAGGTGGAA	0.488													0	0	0	0.062417	0	23	50										T	2312402	C	T	2312402	3	4	45	1	0	0	0	0	1	0	0	0	13511	594	21	2	376	2	RNPS1	16	2312402	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		2312402	88042351	185	11648										
ZNF205	7755	broad.mit.edu	37	chr16	3170223	3170223	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ccggcgctccaacctgcaccGgcacgagaagatccacacca	9	18	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:3170223G>A	uc002cub.2	+	7	1697	c.1562G>A	c.(1561-1563)CGG>CAG	p.R521Q	ZNF205_uc002cua.2_Missense_Mutation_p.R521Q	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	521	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						AACCTGCACCGGCACGAGAAG	0.632													0	0	0	0.047766	0	9	22										A	3170223	G	A	3170223	3	1	45	1	0	0	0	0	1	0	0	0	17761	1116	39	2	1584	2	ZNF205	16	3170223	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	857821	3170223	87184530	186	11649										
CLUAP1	23059	broad.mit.edu	37	chr16	3569975	3569975	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctaatttagaagccaaaatcGaaaagagaaaattagaactg	7	5	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:3569975G>A	uc002cvk.1	+	7	757	c.652G>A	c.(652-654)GAA>AAA	p.E218K	CLUAP1_uc002cvj.1_Missense_Mutation_p.E218K|CLUAP1_uc002cvl.1_Missense_Mutation_p.E218K|CLUAP1_uc002cvm.1_Missense_Mutation_p.E52K	NM_015041	NP_055856	Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1 isoform 1	218	Potential.					nucleus	protein binding			ovary(1)|breast(1)|pancreas(1)	3						AGCCAAAATCGAAAAGAGAAA	0.383													0	0	0	0.09836	0	40	147										A	3569975	G	A	3569975	3	1	45	1	0	0	0	0	1	0	0	0	3569	1059	37	1	678	1	CLUAP1	16	3569975	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	399752	3569975	86784778	187	11650										
C16orf62	57020	broad.mit.edu	37	chr16	19621680	19621680	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgccccggttgacatgcatGatcagagggatcggagaccc	13	12	1	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:19621680G>A	uc002dgn.1	+	12	978	c.966G>A	c.(964-966)ATG>ATA	p.M322I	C16orf62_uc002dgo.1_Missense_Mutation_p.M322I|C16orf62_uc002dgp.1_Missense_Mutation_p.M71I|C16orf62_uc010vas.1_Missense_Mutation_p.M196I|C16orf62_uc002dgm.1_Missense_Mutation_p.M322I	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	322						integral to membrane				ovary(1)	1						TGACATGCATGATCAGAGGGA	0.547													0	0	0	0.021553	0	5	17										A	19621680	G	A	19621680	3	1	45	1	0	0	0	0	1	0	0	0	1825	1290	45	1	1012	1	C16orf62	16	19621680	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	16051705	19621680	70733073	188	11651										
NLRC5	84166	broad.mit.edu	37	chr16	57063929	57063929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgagcagcaacagcatctgcGtgtcaaccctactctgcttg	9	13	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:57063929G>A	uc002ekk.1	+	10	2575	c.2350G>A	c.(2350-2352)GTG>ATG	p.V784M	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.V533M|NLRC5_uc002ekl.2_Missense_Mutation_p.V589M|NLRC5_uc002ekm.2_Missense_Mutation_p.V589M|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	784	LRR 4.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CAGCATCTGCGTGTCAACCCT	0.577													0	0	0	0.043863	0	20	58										A	57063929	G	A	57063929	3	1	45	1	0	0	0	0	1	0	0	0	10470	1145	40	2	2380	2	NLRC5	16	57063929	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	37442249	57063929	33290824	189	11652										
DOK4	55715	broad.mit.edu	37	chr16	57508776	57508776	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagcagaggggccacgagacGagcttcacacgggggttgtg	18	9	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:57508776G>A	uc010cdb.2	-	5	826	c.528C>T	c.(526-528)CTC>CTT	p.L176L	DOK4_uc002elu.1_Silent_p.L176L|DOK4_uc002elv.3_Silent_p.L176L	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	176	IRS-type PTB.						insulin receptor binding			skin(1)	1						GCCACGAGACGAGCTTCACAC	0.637													0	0	0	0.080935	0	11	30										A	57508776	G	A	57508776	2	1	45	1	0	0	0	0	0	0	0	1	4699	1045	37	1		1	DOK4	16	57508776	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	444847	57508776	32845977	190	11653										
CCDC135	84229	broad.mit.edu	37	chr16	57757006	57757006	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agaccacagacctgaagacaGactacttcaagcctggccac	8	14	1	5			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:57757006G>A	uc002emi.2	+	11	1590	c.1501G>A	c.(1501-1503)GAC>AAC	p.D501N	CCDC135_uc002emj.2_Missense_Mutation_p.D501N|CCDC135_uc002emk.2_Missense_Mutation_p.D436N	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	501						cytoplasm				central_nervous_system(1)	1						CCTGAAGACAGACTACTTCAA	0.577													0	0	0	0.144211	0	31	75										A	57757006	G	A	57757006	3	1	45	1	0	0	0	0	1	0	0	0	2769	942	33	1	1539	1	CCDC135	16	57757006	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	248230	57757006	32597747	191	11654										
CCDC113	29070	broad.mit.edu	37	chr16	58292407	58292407	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agaaagtgatgaaatacattGaggacatgaaccgccggagg	13	6	0	5	rs151051990		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:58292407G>A	uc002ene.2	+	4	605	c.526G>A	c.(526-528)GAG>AAG	p.E176K	CCDC113_uc010vid.1_Missense_Mutation_p.E122K	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	176	Potential.					protein complex					0						GAAATACATTGAGGACATGAA	0.408													0	0	0	0.105934	0	13	61										A	58292407	G	A	58292407	3	1	45	1	0	0	0	0	1	0	0	0	2750	1291	45	1	540	1	CCDC113	16	58292407	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	535401	58292407	32062346	192	11655										
ZFHX3	463	broad.mit.edu	37	chr16	72992824	72992824	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggggtcttcagtaccgagctGgtgagcccgccaaggttcaa	14	11	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:72992824G>A	uc002fck.2	-	2	1894	c.1221C>T	c.(1219-1221)ACC>ACT	p.T407T	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	407					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GTACCGAGCTGGTGAGCCCGC	0.657													0	0	0	0.104719	0	40	106										A	72992824	G	A	72992824	2	1	45	1	0	0	0	0	0	0	0	1	17631	1335	47	2		2	ZFHX3	16	72992824	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	14700417	72992824	17361929	193	11656										
CDYL2	124359	broad.mit.edu	37	chr16	80666970	80666970	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctggacagcaggatgtgcgtGaacccttcttccttccgcac	10	14	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr16:80666970G>T	uc002ffs.2	-	3	885	c.780C>A	c.(778-780)TTC>TTA	p.F260L		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	260						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						GGATGTGCGTGAACCCTTCTT	0.552													1	0	5.45727e-16	0.134883	6.1106e-16	31	85										T	80666970	G	T	80666970	3	4	45	1	0	0	0	0	1	0	0	0	3186	1281	45	3	760	3	CDYL2	16	80666970	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	7674146	80666970	9687783	194	11657										
SMG6	23293	broad.mit.edu	37	chr17	2202737	2202737	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gagatcccttactaccagatCcaaacaaaagccgaggtccc	7	14	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:2202737C>A	uc002fub.1	-	2	1365	c.1310G>T	c.(1309-1311)GGA>GTA	p.G437V	SMG6_uc002fud.1_Missense_Mutation_p.G406V	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	437	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						ACTACCAGATCCAAACAAAAG	0.542													1	0	1.96642e-18	0.092188	2.22534e-18	42	78										A	2202737	C	A	2202737	3	1	45	1	0	0	0	0	1	0	0	0	14797	855	30	3	3021	3	SMG6	17	2202737	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08		2202737	78992473	195	11658										
SRR	63826	broad.mit.edu	37	chr17	2222174	2222174	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccagactgtaaaaaacttgCaatacaagcctacggagcgt	8	10	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:2222174C>G	uc002fue.1	+	4	418	c.350C>G	c.(349-351)GCA>GGA	p.A117G	SRR_uc002fui.1_5'UTR	NM_021947	NP_068766	Q9GZT4	SRR_HUMAN	serine racemase	117					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity				0		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AAAAAACTTGCAATACAAGCC	0.438													0	0	0	0.139131	0	57	95										G	2222174	C	G	2222174	3	3	45	1	0	0	0	0	1	0	0	0	15165	710	25	4	360	4	SRR	17	2222174	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	19437	2222174	78973036	196	11659										
TRPV1	7442	broad.mit.edu	37	chr17	3494637	3494637	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gctggcggcgacagagtcctGggacagcagcctgtgggcca	17	12	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:3494637G>A	uc010vrr.1	-	2	822	c.295C>T	c.(295-297)CAG>TAG	p.Q99*	TRPV1_uc010vro.1_Nonsense_Mutation_p.Q99*|TRPV1_uc010vrp.1_Nonsense_Mutation_p.Q99*|TRPV1_uc010vrq.1_Silent_p.P73P|TRPV1_uc010vrs.1_Nonsense_Mutation_p.Q99*|TRPV1_uc010vrt.1_Nonsense_Mutation_p.Q99*|TRPV1_uc010vru.1_Nonsense_Mutation_p.Q99*	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	99	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	ACAGAGTCCTGGGACAGCAGC	0.582													0	0	0	0.058154	0	10	12										A	3494637	G	A	3494637	4	1	45	1	0	0	0	0	0	1	0	0	16592	1357	47	2	1953	2	TRPV1	17	3494637	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	1272463	3494637	77700573	197	11660										
ASGR1	432	broad.mit.edu	37	chr17	7080605	7080605	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agcaggaggaggcgaggtccGgagcagagacgctgcaggag	20	8	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:7080605G>A	uc002ges.3	-	3	521	c.111C>T	c.(109-111)TCC>TCT	p.S37S	ASGR1_uc010clx.1_5'Flank	NM_001671	NP_001662	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	37	Cytoplasmic (Probable).				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)	2						GGCGAGGTCCGGAGCAGAGAC	0.682											OREG0024128	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.115264	0	3	27										A	7080605	G	A	7080605	2	1	45	1	0	0	0	0	0	0	0	1	1039	1103	39	2		2	ASGR1	17	7080605	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3585968	7080605	74114605	198	11661										
TP53	7157	broad.mit.edu	37	chr17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cttgcggagattctcttcctCtgtgcgccggtctctcccag	10	15	3	1	rs112431538		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.132662	0	14	24										T	7577085	C	T	7577085	3	4	45	1	0	0	0	0	1	0	0	0	16378	922	32	1	433	1	TP53	17	7577085	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	496480	7577085	73618125	199	11662										
TP53	7157	broad.mit.edu	37	chr17	7578188	7578188	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aaaccagacctcaggcggctCatagggcaccaccacactat	8	15	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:7578188C>A	uc002gim.2	-	6	855	c.661G>T	c.(661-663)GAG>TAG	p.E221*	TP53_uc002gig.1_Nonsense_Mutation_p.E221*|TP53_uc002gih.2_Nonsense_Mutation_p.E221*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E89*|TP53_uc010cng.1_Nonsense_Mutation_p.E89*|TP53_uc002gii.1_Nonsense_Mutation_p.E89*|TP53_uc010cnh.1_Nonsense_Mutation_p.E221*|TP53_uc010cni.1_Nonsense_Mutation_p.E221*|TP53_uc002gij.2_Nonsense_Mutation_p.E221*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.E128*|TP53_uc002gio.2_Nonsense_Mutation_p.E89*|TP53_uc010vug.1_Nonsense_Mutation_p.E182*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	221	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E221*(5)|p.E221fs*4(3)|p.E221G(2)|p.E221K(2)|p.E221D(2)|p.E221fs*26(2)|p.E221E(2)|p.Y220_P223delYEPP(1)|p.?(1)|p.E221fs*2(1)|p.V218_E224delVPYEPPE(1)|p.V218_E221delVPYE(1)|p.Y220fs*25(1)|p.V218fs*26(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCAGGCGGCTCATAGGGCACC	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	2.31682e-05	0.132662	2.54931e-05	15	15										A	7578188	C	A	7578188	4	1	45	1	0	0	0	0	0	1	0	0	16378	835	29	3	633	3	TP53	17	7578188	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1103	7578188	73617022	200	11663										
MED24	9862	broad.mit.edu	37	chr17	38187864	38187864	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aaaagcacagttgacatcctCagtgaagtcctagaaagagg	10	8	1	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:38187864C>G	uc002htt.2	-	11	1307	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	MED24_uc010wes.1_Missense_Mutation_p.E192Q|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.E357Q|MED24_uc002htu.2_Missense_Mutation_p.E319Q|MED24_uc010cwn.2_Missense_Mutation_p.E319Q|MED24_uc010weu.1_Missense_Mutation_p.E242Q|MED24_uc010wev.1_Missense_Mutation_p.E282Q|MED24_uc010wew.1_Missense_Mutation_p.E261Q|MED24_uc010wex.1_Missense_Mutation_p.E37Q	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	332					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TTGACATCCTCAGTGAAGTCC	0.567													0	0	0	0.038395	0	17	69										G	38187864	C	G	38187864	3	3	45	1	0	0	0	0	1	0	0	0	9442	835	29	1	2039	1	MED24	17	38187864	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	30609676	38187864	43007346	201	11664										
TMEM99	147184	broad.mit.edu	37	chr17	38991464	38991464	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gctttgttatggcaaagcctCatattactctctagtctggt	8	9	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:38991464C>T	uc002hvj.1	+	3	1003	c.696C>T	c.(694-696)CTC>CTT	p.L232L		NM_145274	NP_660317	Q8N816	TMM99_HUMAN	transmembrane protein 99 precursor	232	Helical; (Potential).					integral to membrane				skin(1)	1		Breast(137;0.000301)				GGCAAAGCCTCATATTACTCT	0.398													0	0	0	0.104719	0	45	59										T	38991464	C	T	38991464	2	4	45	1	0	0	0	0	0	0	0	1	16223	813	29	1		1	TMEM99	17	38991464	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	803600	38991464	42203746	202	11665										
SCN4A	6329	broad.mit.edu	37	chr17	62020202	62020202	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcacccacaatggacaggatGacgaccacgaagtcaaagat	9	11	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:62020202G>A	uc002jds.1	-	23	4349	c.4272C>T	c.(4270-4272)GTC>GTT	p.V1424V		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1424	Helical; Name=S3 of repeat IV; (Potential).|IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TGGACAGGATGACGACCACGA	0.602													0	0	0	0.021553	0	6	22										A	62020202	G	A	62020202	2	1	45	1	0	0	0	0	0	0	0	1	13920	1277	45	1		1	SCN4A	17	62020202	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	23028738	62020202	19175008	203	11666										
SGSH	6448	broad.mit.edu	37	chr17	78188482	78188482	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgatgttccgccccacctgGaggacggagccattctcctc	11	15	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr17:78188482G>C	uc002jxz.3	-	4	525	c.438C>G	c.(436-438)CTC>CTG	p.L146L	SGSH_uc002jya.3_5'UTR|SGSH_uc002jxy.2_Silent_p.L146L|SGSH_uc010wue.1_Missense_Mutation_p.S158C	NM_000199	NP_000190	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase precursor	146			L -> P (in MPS3A; severe).		proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCCCCACCTGGAGGACGGAGC	0.612													0	0	0	0.105934	0	13	30										C	78188482	G	C	78188482	2	2	45	1	0	0	0	0	0	0	0	1	14221	1161	41	1		1	SGSH	17	78188482	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	16168280	78188482	3006728	204	11667										
ZNF57	126295	broad.mit.edu	37	chr19	2918122	2918122	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtgaggatgcacactggagaGaaacctcacaaatgtaaaca	10	8	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:2918122G>C	uc002lwr.2	+	4	1651	c.1503G>C	c.(1501-1503)GAG>GAC	p.E501D	ZNF57_uc010xha.1_Missense_Mutation_p.E469D	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	501					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACTGGAGAGAAACCTCACA	0.463													0	0	0	0.108266	0	29	37										C	2918122	G	C	2918122	3	2	45	1	0	0	0	0	1	0	0	0	17998	933	33	1	1517	1	ZNF57	19	2918122	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		2918122	56210861	205	11668										
MUC16	94025	broad.mit.edu	37	chr19	9061174	9061174	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ttctggtgatattgtggattGagcaggacctggggtggatg	17	4	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:9061174G>C	uc002mkp.2	-	3	26476	c.26272C>G	c.(26272-26274)CAA>GAA	p.Q8758E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8760	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATTGTGGATTGAGCAGGACCT	0.498													0	0	0	0.062417	0	22	47										C	9061174	G	C	9061174	3	2	45	1	0	0	0	0	1	0	0	0	9973	1299	45	1	17579	1	MUC16	19	9061174	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	6143052	9061174	50067809	206	11669										
CD97	976	broad.mit.edu	37	chr19	14516631	14516631	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgcctgctgctgtgcatcctCactttcctgctggtgcggcc	11	15	1	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:14516631C>T	uc002myl.2	+	14	1824	c.1701C>T	c.(1699-1701)CTC>CTT	p.L567L	CD97_uc002mym.2_Silent_p.L518L|CD97_uc002myn.2_Silent_p.L474L	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	567	Helical; Name=1; (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						TGTGCATCCTCACTTTCCTGC	0.632													0	0	0	0.116897	0	23	79										T	14516631	C	T	14516631	2	4	45	1	0	0	0	0	0	0	0	1	3049	813	29	1		1	CD97	19	14516631	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	5455457	14516631	44612352	207	11670										
PLVAP	83483	broad.mit.edu	37	chr19	17487865	17487865	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcaagttggactgggaggccGtgagccctaggagctgactg	16	9	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:17487865G>A	uc002ngk.1	-	1	283	c.233C>T	c.(232-234)ACG>ATG	p.T78M		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	78	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTGGGAGGCCGTGAGCCCTAG	0.617													0	0	0	0.069234	0	10	32										A	17487865	G	A	17487865	3	1	45	1	0	0	0	0	1	0	0	0	12116	1145	40	2	1119	2	PLVAP	19	17487865	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	2971234	17487865	41641118	208	11671										
ZNF493	284443	broad.mit.edu	37	chr19	21606279	21606279	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	atgtgaagaatgtggcacatCtttctaccaattctcatacc	6	10	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:21606279C>G	uc002npx.2	+	2	714	c.434C>G	c.(433-435)TCT>TGT	p.S145C	ZNF493_uc002npw.2_Missense_Mutation_p.S273C|ZNF493_uc002npy.2_Missense_Mutation_p.S145C	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	145	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGGCACATCTTTCTACCAA	0.348													0	0	0	0.144211	0	31	106										G	21606279	C	G	21606279	3	3	45	1	0	0	0	0	1	0	0	0	17941	913	32	1	895	1	ZNF493	19	21606279	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4118414	21606279	37522704	209	11672										
PDCD2L	84306	broad.mit.edu	37	chr19	34900411	34900411	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ccatggatcagttgctttccCaaaggtgaggatgtgtgctg	13	8	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:34900411C>A	uc002nvj.2	+	4	715	c.682C>A	c.(682-684)CAA>AAA	p.Q228K		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	228						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GTTGCTTTCCCAAAGGTGAGG	0.507													1	0	0.00909568	0.009096	0.00983818	4	44										A	34900411	C	A	34900411	3	1	45	1	0	0	0	0	1	0	0	0	11620	595	21	4	696	4	PDCD2L	19	34900411	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	13294132	34900411	24228572	210	11673										
RYR1	6261	broad.mit.edu	37	chr19	39001344	39001344	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tacttcaccaaccactgcctCtatttcttgtccactccggc	4	17	3	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:39001344C>G	uc002oit.2	+	60	9175	c.9045C>G	c.(9043-9045)CTC>CTG	p.L3015L	RYR1_uc002oiu.2_Silent_p.L3015L|RYR1_uc002oiv.1_5'UTR|RYR1_uc010xuf.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3015	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACCACTGCCTCTATTTCTTGT	0.567													0	0	0	0.139131	0	46	152										G	39001344	C	G	39001344	2	3	45	1	0	0	0	0	0	0	0	1	13768	900	32	1		1	RYR1	19	39001344	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	4100933	39001344	20127639	211	11674										
EID2B	126272	broad.mit.edu	37	chr19	40023151	40023151	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggagctaccatccagatactCgcggaacaacagctgccggt	11	13	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:40023151C>G	uc002olz.1	-	1	344	c.292G>C	c.(292-294)GAG>CAG	p.E98Q		NM_152361	NP_689574	Q96D98	EID2B_HUMAN	EP300 interacting inhibitor of differentiation	98					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCCAGATACTCGCGGAACAAC	0.612													0	0	0	0.038147	0	7	52										G	40023151	C	G	40023151	3	3	45	1	0	0	0	0	1	0	0	0	4988	893	31	1	197	1	EID2B	19	40023151	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1021807	40023151	19105832	212	11675										
MEGF8	1954	broad.mit.edu	37	chr19	42848852	42848852	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgccgaggggagcagatctCaggcactgtgggctggtggg	19	9	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:42848852C>G	uc002otl.3	+	12	2599	c.1964C>G	c.(1963-1965)TCA>TGA	p.S655*	MEGF8_uc002otm.3_Nonsense_Mutation_p.S196*	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	705	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GAGCAGATCTCAGGCACTGTG	0.687													0	0	0	0.0333	0	13	43										G	42848852	C	G	42848852	4	3	45	1	0	0	0	0	0	1	0	0	9463	838	29	1	2010	1	MEGF8	19	42848852	Nonsense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	2825701	42848852	16280131	213	11676										
CEACAM1	634	broad.mit.edu	37	chr19	43026092	43026092	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tcacaggtgacattcaaggtGactgggtcactgcggttcgc	13	10	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:43026092G>A	uc002otv.2	-	3	800	c.687C>T	c.(685-687)GTC>GTT	p.V229V	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_5'Flank|CEACAM1_uc002otw.2_Silent_p.V229V|CEACAM1_uc010eij.2_Silent_p.V229V|CEACAM1_uc002otx.2_Silent_p.V229V|CEACAM1_uc002oty.2_Silent_p.V229V|CEACAM1_uc002otz.2_Silent_p.V229V|CEACAM1_uc010eik.2_Intron|CEACAM1_uc002oua.2_Silent_p.V229V|CEACAM1_uc002oub.2_Silent_p.V229V|CEACAM1_uc002ouc.2_Silent_p.V229V	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	229	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	CATTCAAGGTGACTGGGTCAC	0.557													0	0	0	0.092188	0	40	131										A	43026092	G	A	43026092	2	1	45	1	0	0	0	0	0	0	0	1	3187	1277	45	1		1	CEACAM1	19	43026092	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	177240	43026092	16102891	214	11677										
ZNF575	284346	broad.mit.edu	37	chr19	44039832	44039832	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggtggagcacaagggggagaGagactgagccctcccttggc	17	10	0	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:44039832G>C	uc002ows.2	+	4	1259	c.731G>C	c.(730-732)AGA>ACA	p.R244T	ZNF575_uc002owq.2_Missense_Mutation_p.R343T	NM_174945	NP_777605	Q86XF7	ZN575_HUMAN	zinc finger protein 575	244					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0199)				AAGGGGGAGAGAGACTGAGCC	0.612													0	0	0	0.021553	0	5	19										C	44039832	G	C	44039832	3	2	45	1	0	0	0	0	1	0	0	0	18004	942	33	1	737	1	ZNF575	19	44039832	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	1013740	44039832	15089151	215	11678										
CBLC	23624	broad.mit.edu	37	chr19	45285644	45285644	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cagccatggccaacactcctCaagaactggcagctcctggc	9	16	1	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:45285644C>G	uc002ozs.2	+	4	738	c.675C>G	c.(673-675)CTC>CTG	p.L225L	CBLC_uc010ejt.2_Silent_p.L225L	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	225	SH2-like.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CAACACTCCTCAAGAACTGGC	0.612			M		AML								0	0	0	0.144211	0	25	122										G	45285644	C	G	45285644	2	3	45	1	0	0	0	0	0	0	0	1	2702	813	29	1		1	CBLC	19	45285644	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1245812	45285644	13843339	216	11679										
TBC1D17	79735	broad.mit.edu	37	chr19	50387619	50387619	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acctactgcatgtatcacttCgacctcggtgggtgccaggc	11	13	1	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:50387619C>T	uc002pqo.2	+	11	1388	c.1236C>T	c.(1234-1236)TTC>TTT	p.F412F	TBC1D17_uc010ybg.1_Silent_p.F379F|TBC1D17_uc002pqp.2_Silent_p.F63F|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Silent_p.F63F|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	412	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		TGTATCACTTCGACCTCGGTG	0.662													0	0	0	0.139131	0	51	207										T	50387619	C	T	50387619	2	4	45	1	0	0	0	0	0	0	0	1	15603	883	31	1		1	TBC1D17	19	50387619	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	5101975	50387619	8741364	217	11680										
KLK3	354	broad.mit.edu	37	chr19	51361378	51361378	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	cacagcttcccacacccgctCtacgatatgagcctcctgaa	6	17	1	2	rs2739452		TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:51361378C>G	uc002pts.1	+	3	341	c.300C>G	c.(298-300)CTC>CTG	p.L100L	KLK3_uc010ycj.1_Silent_p.L100L|KLK3_uc002ptr.1_Intron|KLK3_uc010eof.1_Intron	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	100	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		CACACCCGCTCTACGATATGA	0.582													0	0	0	0.021553	0	6	46										G	51361378	C	G	51361378	2	3	45	1	0	0	0	0	0	0	0	1	8405	900	32	1		1	KLK3	19	51361378	Silent	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	973759	51361378	7767605	218	11681										
LILRA3	11026	broad.mit.edu	37	chr19	54802062	54802062	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gaattcagcctggtacttatGagattggcgctttgatttta	10	6	1	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:54802062G>A	uc002qfd.2	-	6	1191	c.1126C>T	c.(1126-1128)CAT>TAT	p.H376Y	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.H312Y	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	376	Ig-like C2-type 4.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGTACTTATGAGATTGGCGC	0.577													0	0	0	0.059317	0	33	103										A	54802062	G	A	54802062	3	1	45	1	0	0	0	0	1	0	0	0	8786	1290	45	1	201	1	LILRA3	19	54802062	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	3440684	54802062	4326921	219	11682										
TTYH1	57348	broad.mit.edu	37	chr19	54932504	54932504	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgagaccagtgatggggtgtCccagctcagctctgcgctgc	14	12	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:54932504C>G	uc002qfq.2	+	3	451	c.359C>G	c.(358-360)TCC>TGC	p.S120C	TTYH1_uc010yey.1_Missense_Mutation_p.S169C|TTYH1_uc002qfr.2_Missense_Mutation_p.S120C|TTYH1_uc002qft.2_Missense_Mutation_p.S120C|TTYH1_uc002qfu.1_Missense_Mutation_p.S35C	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	120	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GATGGGGTGTCCCAGCTCAGC	0.627													0	0	0	0.058154	0	10	60										G	54932504	C	G	54932504	3	3	45	1	0	0	0	0	1	0	0	0	16736	855	30	1	369	1	TTYH1	19	54932504	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	130442	54932504	4196479	220	11683										
NLRP9	338321	broad.mit.edu	37	chr19	56243927	56243927	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	acccacccacatcacgccctCagactcagataacccattcc	3	20	3	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:56243927C>G	uc002qly.2	-	2	1298	c.1270G>C	c.(1270-1272)GAG>CAG	p.E424Q		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	424	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ATCACGCCCTCAGACTCAGAT	0.483													0	0	0	0.139131	0	49	187										G	56243927	C	G	56243927	3	3	45	1	0	0	0	0	1	0	0	0	10484	835	29	1	1737	1	NLRP9	19	56243927	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	1311423	56243927	2885056	221	11684										
ZNF582	147948	broad.mit.edu	37	chr19	56895710	56895710	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gtttctcaccggtatgaattCtctgatgtcgtataagagtt	9	7	2	3			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:56895710C>T	uc002qmz.1	-	5	1235	c.1076G>A	c.(1075-1077)AGA>AAA	p.R359K	ZNF582_uc002qmy.2_Missense_Mutation_p.R390K	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	359	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GGTATGAATTCTCTGATGTCG	0.418													0	0	0	0.083992	0	25	193										T	56895710	C	T	56895710	3	4	45	1	0	0	0	0	1	0	0	0	18011	913	32	1	481	1	ZNF582	19	56895710	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	651783	56895710	2233273	222	11685										
ZNF418	147686	broad.mit.edu	37	chr19	58438051	58438051	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tccagtgtgaactctctgatGaacacgaaacccagagctgt	9	11	1	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:58438051G>A	uc002qqs.1	-	4	1790	c.1498C>T	c.(1498-1500)CAT>TAT	p.H500Y	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.H415Y	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	500	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		ACTCTCTGATGAACACGAAAC	0.448													0	0	0	0.139131	0	150	94										A	58438051	G	A	58438051	3	1	45	1	0	0	0	0	1	0	0	0	17892	1290	45	1	536	1	ZNF418	19	58438051	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	1542341	58438051	690932	223	11686										
ZBTB45	84878	broad.mit.edu	37	chr19	59028353	59028353	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggaaggaggtgcctggccctCgcctgggccgccaccttcgc	15	16	0	0			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr19:59028353C>T	uc002qtd.2	-	2	980	c.688G>A	c.(688-690)GAG>AAG	p.E230K	ZBTB45_uc002qte.2_Missense_Mutation_p.E230K|ZBTB45_uc002qtf.2_Missense_Mutation_p.E230K	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GCCTGGCCCTCGCCTGGGCCG	0.672											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	51	270										T	59028353	C	T	59028353	3	4	45	1	0	0	0	0	1	0	0	0	17543	893	31	1	855	1	ZBTB45	19	59028353	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	590302	59028353	100630	224	11687										
HNF4A	3172	broad.mit.edu	37	chr20	43030114	43030114	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tttgagaatgtgcaggtgttGacgatgggcaatggtaggtg	17	3	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr20:43030114G>A	uc002xma.2	+	1	191	c.102G>A	c.(100-102)TTG>TTA	p.L34L	HNF4A_uc010zwo.1_Intron|HNF4A_uc002xlt.2_Intron|HNF4A_uc002xlu.2_Intron|HNF4A_uc002xlv.2_Intron|uc002xlw.1_Intron|HNF4A_uc002xly.2_Silent_p.L34L|HNF4A_uc002xlz.2_Silent_p.L34L|HNF4A_uc010ggq.2_5'UTR	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	34					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			TGCAGGTGTTGACGATGGGCA	0.587													0	0	0	0.021553	0	5	36										A	43030114	G	A	43030114	2	1	45	1	0	0	0	0	0	0	0	1	7253	1281	45	1		1	HNF4A	20	43030114	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		43030114	19995406	225	11688										
C20orf85	128602	broad.mit.edu	37	chr20	56728657	56728657	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	aactggccccagaactggggGtttttaacaaccccttttga	9	11	0	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr20:56728657G>A	uc002xyv.2	+	2	164	c.126G>A	c.(124-126)GGG>GGA	p.G42G		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	42										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			AGAACTGGGGGTTTTTAACAA	0.428													0	0	0	0.083992	0	24	106										A	56728657	G	A	56728657	2	1	45	1	0	0	0	0	0	0	0	1	2120	1248	44	2		2	C20orf85	20	56728657	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	13698543	56728657	6296863	226	11689										
CDH4	1002	broad.mit.edu	37	chr20	60419818	60419818	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ggaggtcttcagcattgactCcatgtccggccggatgtacg	13	11	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr20:60419818C>G	uc002ybn.1	+	5	685	c.671C>G	c.(670-672)TCC>TGC	p.S224C	CDH4_uc002ybp.1_Missense_Mutation_p.S150C	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	224	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			AGCATTGACTCCATGTCCGGC	0.617													0	0	0	0.146539	0	15	34										G	60419818	C	G	60419818	3	3	45	1	0	0	0	0	1	0	0	0	3112	855	30	1	689	1	CDH4	20	60419818	Missense_Mutation	SNP	C	TCGA-DK-A1AB-01A-11D-A13W-08	3691161	60419818	2605702	227	11690										
NPBWR2	2832	broad.mit.edu	37	chr20	62737520	62737520	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	agatggtgcacacgggcagcAcgaagcccaggaccaacgtg	14	12	0	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr20:62737520A>C	uc011abt.1	-	1	665	c.665T>G	c.(664-666)GTG>GGG	p.V222G		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	222	Helical; Name=5; (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CACGGGCAGCACGAAGCCCAG	0.657													0	0	0	0.069234	0	8	19										C	62737520	A	C	62737520	3	2	45	1	0	0	0	0	1	0	0	0	10569	159	6	5	339	5	NPBWR2	20	62737520	Missense_Mutation	SNP	A	TCGA-DK-A1AB-01A-11D-A13W-08	2317702	62737520	288000	228	11691										
KRTAP24-1	643803	broad.mit.edu	37	chr21	31654758	31654758	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	actcaatctgcagtggtttaGagtttggaaactcttggata	10	6	3	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr21:31654758G>C	uc002ynv.2	-	1	519	c.493C>G	c.(493-495)CTA>GTA	p.L165V		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	165						keratin filament	structural molecule activity				0						CAGTGGTTTAGAGTTTGGAAA	0.443													0	0	0	0.104719	0	40	121										C	31654758	G	C	31654758	3	2	45	1	0	0	0	0	1	0	0	0	8542	933	33	1	275	1	KRTAP24-1	21	31654758	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		31654758	16475137	229	11692										
DYRK1A	1859	broad.mit.edu	37	chr21	38862650	38862650	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgcttttccttgcgactccaGaacttagtatcattcactgt	6	11	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chr21:38862650G>C	uc002ywk.2	+	6	913	c.838G>C	c.(838-840)GAA>CAA	p.E280Q	DYRK1A_uc002ywi.2_Missense_Mutation_p.E280Q|DYRK1A_uc002ywj.2_Missense_Mutation_p.E271Q|DYRK1A_uc002ywl.2_Missense_Mutation_p.E280Q|DYRK1A_uc002ywm.2_Missense_Mutation_p.E280Q|DYRK1A_uc011aei.1_Missense_Mutation_p.E41Q	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	280	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						TGCGACTCCAGAACTTAGTAT	0.428													0	0	0	0.014758	0	5	124										C	38862650	G	C	38862650	3	2	45	1	0	0	0	0	1	0	0	0	4854	943	33	1	860	1	DYRK1A	21	38862650	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	7207892	38862650	9267245	230	11693										
KDM6A	7403	broad.mit.edu	37	chrX	44969327	44969327	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tctcttgtataaaacaggtgGaggtttttgatctgcttttt	9	5	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chrX:44969327G>T	uc004dge.3	+	28	4384	c.4009G>T	c.(4009-4011)GAG>TAG	p.E1337*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.E1389*|KDM6A_uc011mla.1_Nonsense_Mutation_p.E1292*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.E1344*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.E1041*|KDM6A_uc011mld.1_Nonsense_Mutation_p.E976*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1337					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAACAGGTGGAGGTTTTTGA	0.348			D|N|F|S		renal|oesophageal SCC|MM								1	0	0.00307968	0.038147	0.00337703	8	71										T	44969327	G	T	44969327	4	4	45	1	0	0	0	0	0	1	0	0	8137	1175	41	3	4119	3	KDM6A	23	44969327	Nonsense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08		44969327	110301233	231	11694										
APEX2	27301	broad.mit.edu	37	chrX	55033263	55033263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	tgagtgtgtcctctgtgcctGcaaaacagtgcccacctctg	10	13	2	1			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chrX:55033263G>A	uc004dtz.2	+	6	1028	c.952G>A	c.(952-954)GCA>ACA	p.A318T	APEX2_uc011mom.1_Missense_Mutation_p.A147T	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	318					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						CTCTGTGCCTGCAAAACAGTG	0.567								Other_BER_factors					0	0	0	0.105934	0	13	24										A	55033263	G	A	55033263	3	1	45	1	0	0	0	0	1	0	0	0	770	1319	46	2	974	2	APEX2	23	55033263	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	10063936	55033263	100237297	232	11695										
KIAA2022	340533	broad.mit.edu	37	chrX	73964271	73964271	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	gataggtgcagcagcttctaGagctgcaaatgacttcattg	11	8	2	2			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chrX:73964271G>C	uc004eby.2	-	3	738	c.121C>G	c.(121-123)CTA>GTA	p.L41V		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	41					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCAGCTTCTAGAGCTGCAAAT	0.463													0	0	0	0.105934	0	12	10										C	73964271	G	C	73964271	3	2	45	1	0	0	0	0	1	0	0	0	8269	933	33	1	4437	1	KIAA2022	23	73964271	Missense_Mutation	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	18931008	73964271	81306289	233	11696										
CDR1	1038	broad.mit.edu	37	chrX	139865962	139865962	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.63519313304721	148	3.85601208412945e-61	4.1372662425294	4.58322276278933	3.82908490739043	0.136856447809578	0.26519828609613	112	ctgaagatccacgtcttccaGaaaatccatgtcttccagaa	6	12	2	4			TCGA-DK-A1AB-01A-11D-A13W-08	TCGA-DK-A1AB-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5f0fb2ba-0351-4ce0-8b74-31aa3deecae1	6bb1a3eb-1659-4df1-935d-f8b2d710ace4	g.chrX:139865962G>A	uc004fbg.1	-	1	762	c.570C>T	c.(568-570)TTC>TTT	p.F190F	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	190	5 X 6 AA approximate repeats.|3.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				ACGTCTTCCAGAAAATCCATG	0.448													0	0	0	0.139131	0	69	139										A	139865962	G	A	139865962	2	1	45	1	0	0	0	0	0	0	0	1	3171	933	33	1		1	CDR1	23	139865962	Silent	SNP	G	TCGA-DK-A1AB-01A-11D-A13W-08	65901691	139865962	15404598	234	11697										
SDF4	51150	broad.mit.edu	37	chr1	1153867	1153867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcggcggtcacgatgccgtCgtggttggagtcaatgagct	15	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1153867C>T	uc001adh.3	-	6	1212	c.883G>A	c.(883-885)GAC>AAC	p.D295N	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_Missense_Mutation_p.D295N|SDF4_uc009vjv.2_Missense_Mutation_p.D173N|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	295	EF-hand 5.|5 (Potential).				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		ACGATGCCGTCGTGGTTGGAG	0.642													0	0	0	0.001855	0	12	30										T	1153867	C	T	1153867	3	4	46	1	0	0	0	0	1	0	0	0	13962	884	31	1	329	1	SDF4	1	1153867	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		1153867	248096754	1	11698										
FAM132A	388581	broad.mit.edu	37	chr1	1178268	1178268	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagaccctgctgttgctctCcaggcctgagacggcctcca	11	15	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1178268C>G	uc001adl.1	-	7	789	c.757G>C	c.(757-759)GAG>CAG	p.E253Q		NM_001014980	NP_001014980	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	253						extracellular region					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTGTTGCTCTCCAGGCCTGAG	0.682													0	0	0	0.009096	0	3	28										G	1178268	C	G	1178268	3	3	46	1	0	0	0	0	1	0	0	0	5442	864	30	1	159	1	FAM132A	1	1178268	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	24401	1178268	248072353	2	11699										
SCNN1D	6339	broad.mit.edu	37	chr1	1225697	1225697	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgatggtggagacctgctCctgtggctactacctccacc	11	14	0	2	rs137911309	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1225697C>T	uc001adu.1	+	12	1841	c.1217C>T	c.(1216-1218)TCC>TTC	p.S406F	SCNN1D_uc001adt.1_Missense_Mutation_p.S570F|SCNN1D_uc001adw.2_Missense_Mutation_p.S472F|SCNN1D_uc001adx.2_Missense_Mutation_p.S195F|SCNN1D_uc001adv.2_Missense_Mutation_p.S406F	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GAGACCTGCTCCTGTGGCTAC	0.672													0	0	0	0.008291	0	4	15										T	1225697	C	T	1225697	3	4	46	1	0	0	0	0	1	0	0	0	13929	855	30	1	1453	1	SCNN1D	1	1225697	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	47429	1225697	248024924	3	11700										
SCNN1D	6339	broad.mit.edu	37	chr1	1226989	1226989	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttgagactctggacacctGaaccagacctgccagggctg	11	14	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1226989G>A	uc001adu.1	+	17	2540	c.1916G>A	c.(1915-1917)TGA>TAA	p.*639*	SCNN1D_uc001adt.1_Silent_p.*803*|SCNN1D_uc001adw.2_Silent_p.*705*|SCNN1D_uc001adx.2_Silent_p.*428*|SCNN1D_uc001adv.2_Silent_p.*639*	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CTGGACACCTGAACCAGACCT	0.677													0	0	0	0.012213	0	29	17										A	1226989	G	A	1226989	2	1	46	1	0	0	0	0	0	0	0	1	13929	1285	45	1		1	SCNN1D	1	1226989	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1292	1226989	248023632	4	11701										
PUSL1	126789	broad.mit.edu	37	chr1	1244841	1244841	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgccgccatagggtcctgCgggccttccgagtgcccagc	13	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1244841C>T	uc001aed.2	+	4	361	c.331C>T	c.(331-333)CGG>TGG	p.R111W	ACAP3_uc001aeb.2_5'Flank|ACAP3_uc001aec.1_5'UTR|PUSL1_uc010nyi.1_5'UTR|PUSL1_uc009vjx.2_5'UTR	NM_153339	NP_699170	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	111					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TAGGGTCCTGCGGGCCTTCCG	0.672													0	0	0	0.001984	0	6	5										T	1244841	C	T	1244841	3	4	46	1	0	0	0	0	1	0	0	0	12835	759	27	2	345	2	PUSL1	1	1244841	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	17852	1244841	248005780	5	11702										
MXRA8	54587	broad.mit.edu	37	chr1	1290312	1290312	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgcagaaaaaggggcccgtaGgcgcggcgctcgcccgacgc	16	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1290312G>A	uc001aew.2	-	5	730	c.699C>T	c.(697-699)GCC>GCT	p.A233A	MXRA8_uc001aex.3_Silent_p.A233A|MXRA8_uc001aey.3_Silent_p.A233A|MXRA8_uc010nyl.1_Silent_p.A233A|MXRA8_uc001aez.2_Silent_p.A132A|MXRA8_uc001afa.2_Silent_p.A224A	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	233	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGGCCCGTAGGCGCGGCGCT	0.721													0	0	0	0.000602	0	4	8										A	1290312	G	A	1290312	2	1	46	1	0	0	0	0	0	0	0	1	10005	987	35	2		2	MXRA8	1	1290312	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	45471	1290312	247960309	6	11703										
CCNL2	81669	broad.mit.edu	37	chr1	1334489	1334489	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgtcggtgtcgaggccgctCgacatggacggcgtgaaacg	17	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1334489C>T	uc001afi.2	-	1	230	c.198G>A	c.(196-198)TCG>TCA	p.S66S	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Silent_p.S66S|CCNL2_uc001afj.2_Silent_p.S66S|CCNL2_uc001afk.2_Silent_p.S66S|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	66					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CGAGGCCGCTCGACATGGACG	0.672													0	0	0	0.001168	0	4	36										T	1334489	C	T	1334489	2	4	46	1	0	0	0	0	0	0	0	1	2932	871	31	1		1	CCNL2	1	1334489	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	44177	1334489	247916132	7	11704										
ATAD3A	55210	broad.mit.edu	37	chr1	1459719	1459719	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggacgtggcccccatggggCgggaaggcgtgaccgccatg	19	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1459719C>T	uc001afz.1	+	11	1394	c.1300C>T	c.(1300-1302)CGG>TGG	p.R434W	ATAD3A_uc001aga.1_Missense_Mutation_p.R386W|ATAD3A_uc001agb.1_Missense_Mutation_p.R307W	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	434							ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		CCCCATGGGGCGGGAAGGCGT	0.647													0	0	0	0.010729	0	8	59										T	1459719	C	T	1459719	3	4	46	1	0	0	0	0	1	0	0	0	1073	759	27	2	1342	2	ATAD3A	1	1459719	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	125230	1459719	247790902	8	11705										
GNB1	2782	broad.mit.edu	37	chr1	1720630	1720630	+	Missense_Mutation	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgggagtaagtcatgagctCctggtcagcacgaaggtcaa							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1720630C>T	uc001aif.2	-	10	1110	c.778G>A	c.(778-780)GAG>AAG	p.E260K	GNB1_uc009vky.2_Missense_Mutation_p.E160K	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	260					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GTCATGAGCTCCTGGTCAGCA	0.527											OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007835	0	39	31										T	1720630	C	T	1720630	3	4	46	1	0	0	0	0	1	0	0	0	6515	864	30	1	252	1	GNB1	1	1720630	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	260911	1720630	247529991	9	11706	53	2								
GNB1	2782	broad.mit.edu	37	chr1	1720636	1720636	+	Missense_Mutation	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtaagtcatgagctcctggtCagcacgaaggtcaaacagcc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1720636C>T	uc001aif.2	-	10	1104	c.772G>A	c.(772-774)GAC>AAC	p.D258N	GNB1_uc009vky.2_Missense_Mutation_p.D158N	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	258					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		AGCTCCTGGTCAGCACGAAGG	0.532											OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	9	61										T	1720636	C	T	1720636	3	4	46	1	0	0	0	0	1	0	0	0	6515	826	29	1	258	1	GNB1	1	1720636	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6	1720636	247529985	10	11707	53	2								
C1orf86	199990	broad.mit.edu	37	chr1	2125482	2125482	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcacctcgtgatccaggatCagctccgggctcaccgtgcg	13	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:2125482C>T	uc001aiy.2	-	2	179	c.153G>A	c.(151-153)CTG>CTA	p.L51L	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Intron	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	51											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GATCCAGGATCAGCTCCGGGC	0.677													0	0	0	0.00333	0	24	58										T	2125482	C	T	2125482	2	4	46	1	0	0	0	0	0	0	0	1	2063	813	29	1		1	C1orf86	1	2125482	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	404846	2125482	247125139	11	11708										
MORN1	79906	broad.mit.edu	37	chr1	2268254	2268254	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagccctgctccactcgctGacaggccccgggacaatggg	12	16	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:2268254G>A	uc001ajb.1	-	11	1093	c.1072C>T	c.(1072-1074)CAG>TAG	p.Q358*	MORN1_uc009vld.2_Nonsense_Mutation_p.Q334*	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	358										ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		TCCACTCGCTGACAGGCCCCG	0.652													0	0	0	0.001855	0	11	15										A	2268254	G	A	2268254	4	1	46	1	0	0	0	0	0	1	0	0	9708	1299	45	1	437	1	MORN1	1	2268254	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	142772	2268254	246982367	12	11709										
C1orf93	127281	broad.mit.edu	37	chr1	2520475	2520475	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtctgtgccagcgacccgcCtcaggtgagctgggccttgg	16	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:2520475C>G	uc001aju.1	+	6	651	c.575C>G	c.(574-576)CCT>CGT	p.P192R	C1orf93_uc001ajw.1_Silent_p.A181A|C1orf93_uc001ajv.1_Missense_Mutation_p.P210R|C1orf93_uc010nzd.1_Missense_Mutation_p.P188R|C1orf93_uc010nze.1_Missense_Mutation_p.P156R|C1orf93_uc010nzf.1_Missense_Mutation_p.P155R|C1orf93_uc001ajx.1_Missense_Mutation_p.L65V	NM_152371	NP_689584	Q8TBF2	PGFS_HUMAN	hypothetical protein LOC127281	192					prostaglandin biosynthetic process	cytosol	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor			central_nervous_system(1)	1	all_cancers(77;0.000167)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.97e-16)|all_lung(118;3.05e-07)|Lung NSC(185;2.8e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Lung SC(97;0.109)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Epithelial(90;4.76e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.19e-23)|GBM - Glioblastoma multiforme(42;1.13e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.00205)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		AGCGACCCGCCTCAGGTGAGC	0.682													0	0	0	0.004007	0	15	29										G	2520475	C	G	2520475	3	3	46	1	0	0	0	0	1	0	0	0	2070	681	24	4	597	4	C1orf93	1	2520475	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	252221	2520475	246730146	13	11710										
PRDM16	63976	broad.mit.edu	37	chr1	3319489	3319489	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggctgaggagctcaagcccGagggccttggcggtggcagc	18	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:3319489G>C	uc001akf.2	+	6	891	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	PRDM16_uc001akc.2_Missense_Mutation_p.E271Q|PRDM16_uc001akd.2_Missense_Mutation_p.E271Q|PRDM16_uc001ake.2_Missense_Mutation_p.E271Q|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	271					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCTCAAGCCCGAGGGCCTTGG	0.622			T	EVI1	MDS|AML								0	0	0	0.010729	0	11	49										C	3319489	G	C	3319489	3	2	46	1	0	0	0	0	1	0	0	0	12457	1059	37	1	833	1	PRDM16	1	3319489	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	799014	3319489	245931132	14	11711										
TPRG1L	127262	broad.mit.edu	37	chr1	3542350	3542350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctgcttatctgtaaatacGacttcatcagtctccagtgc	6	13	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:3542350G>A	uc001akm.2	+	3	448	c.367G>A	c.(367-369)GAC>AAC	p.D123N	TPRG1L_uc009vlj.2_Intron	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	123						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		CTGTAAATACGACTTCATCAG	0.547													0	0	0	0.00308	0	8	36										A	3542350	G	A	3542350	3	1	46	1	0	0	0	0	1	0	0	0	16416	1058	37	1	377	1	TPRG1L	1	3542350	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	222861	3542350	245708271	15	11712										
WDR8	49856	broad.mit.edu	37	chr1	3547608	3547608	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtctccaggaagcagaggcaGaagtgatccttgctgaggag	15	8	1	4	rs145375547		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:3547608G>A	uc001ako.2	-	12	1422	c.1314C>T	c.(1312-1314)TTC>TTT	p.F438F	WDR8_uc001akn.3_3'UTR	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	438						centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGCAGAGGCAGAAGTGATCCT	0.592													0	0	0	0.011902	0	44	77										A	3547608	G	A	3547608	2	1	46	1	0	0	0	0	0	0	0	1	17326	933	33	1		1	WDR8	1	3547608	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5258	3547608	245703013	16	11713										
CHD5	26038	broad.mit.edu	37	chr1	6195343	6195343	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctcggtcttggccggcatGttcttgaacacgtcagcctt	11	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:6195343G>A	uc001amb.1	-	18	2917	c.2817C>T	c.(2815-2817)AAC>AAT	p.N939N	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	939					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGGCCGGCATGTTCTTGAACA	0.597													0	0	0	0.005443	0	27	83										A	6195343	G	A	6195343	2	1	46	1	0	0	0	0	0	0	0	1	3328	1368	48	2		2	CHD5	1	6195343	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2647735	6195343	243055278	17	11714										
DNAJC11	55735	broad.mit.edu	37	chr1	6696217	6696217	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcactgtccagcaccatCacctgatgcaggacgccccg	9	18	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:6696217C>T	uc001aof.2	-	15	1720	c.1614G>A	c.(1612-1614)GTG>GTA	p.V538V	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.V486V|DNAJC11_uc010nzu.1_Silent_p.V448V	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	538					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCACCATCACCTGATGCA	0.597													0	0	0	0.004656	0	27	36										T	6696217	C	T	6696217	2	4	46	1	0	0	0	0	0	0	0	1	4630	813	29	1		1	DNAJC11	1	6696217	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	500874	6696217	242554404	18	11715										
RERE	473	broad.mit.edu	37	chr1	8420690	8420690	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggggaggcaggttggcattCatggagaagggtgagggccc	21	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:8420690C>T	uc001ape.2	-	19	3687	c.2877G>A	c.(2875-2877)ATG>ATA	p.M959I	RERE_uc001apf.2_Missense_Mutation_p.M959I|RERE_uc010nzx.1_Missense_Mutation_p.M691I|RERE_uc001apd.2_Missense_Mutation_p.M405I	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	959	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGTTGGCATTCATGGAGAAGG	0.687													0	0	0	0.00632	0	24	100										T	8420690	C	T	8420690	3	4	46	1	0	0	0	0	1	0	0	0	13231	826	29	1	1847	1	RERE	1	8420690	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1724473	8420690	240829931	19	11716										
SLC25A33	84275	broad.mit.edu	37	chr1	9613859	9613859	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacctggactctttcaggttCtgaagtaagttcagtcttgt	9	9	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:9613859C>T	uc001apw.2	+	2	455	c.232C>T	c.(232-234)CTG>TTG	p.L78L	SLC25A33_uc001apx.2_5'UTR	NM_032315	NP_115691	Q9BSK2	S2533_HUMAN	mitochondrial carrier protein MGC4399	78	Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CTTTCAGGTTCTGAAGTAAGT	0.493													0	0	0	0.00308	0	7	44										T	9613859	C	T	9613859	2	4	46	1	0	0	0	0	0	0	0	1	14497	912	32	1		1	SLC25A33	1	9613859	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1193169	9613859	239636762	20	11717										
RBP7	116362	broad.mit.edu	37	chr1	10067689	10067689	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacagaaagtgattgagcaGaatggggattcttttaccat	10	7	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:10067689G>A	uc001aqq.2	+	2	197	c.135G>A	c.(133-135)CAG>CAA	p.Q45Q	RBP7_uc009vms.2_RNA	NM_052960	NP_443192	Q96R05	RET7_HUMAN	retinol binding protein 7, cellular	45						cytoplasm	retinal binding|retinol binding|transporter activity				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|BRCA - Breast invasive adenocarcinoma(304;0.000302)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00856)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	TGATTGAGCAGAATGGGGATT	0.368													0	0	0	0.008871	0	20	62										A	10067689	G	A	10067689	2	1	46	1	0	0	0	0	0	0	0	1	13160	933	33	1		1	RBP7	1	10067689	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	453830	10067689	239182932	21	11718										
UBE4B	10277	broad.mit.edu	37	chr1	10195078	10195078	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttggtgtctacagatggattTatgctgaatttcctttgggt	11	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:10195078T>A	uc001aqs.3	+	16	2771	c.2058T>A	c.(2056-2058)TTT>TTA	p.F686L	UBE4B_uc001aqr.3_Missense_Mutation_p.F557L|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.F141L|UBE4B_uc001aqt.1_Missense_Mutation_p.F26L	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	686					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CAGATGGATTTATGCTGAATT	0.294													0	0	0	0.012319	0	21	93										A	10195078	T	A	10195078	3	1	46	1	0	0	0	0	1	0	0	0	16880	1751	61	5	2120	5	UBE4B	1	10195078	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	127389	10195078	239055543	22	11719										
CLCN6	1185	broad.mit.edu	37	chr1	11882771	11882771	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcggtggaggagtgcagccaGaaaggctgcctcgctctgtc	16	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:11882771G>A	uc001ate.3	+	6	479	c.366G>A	c.(364-366)CAG>CAA	p.Q122Q	CLCN6_uc009vnf.1_Silent_p.Q122Q|CLCN6_uc009vng.1_Silent_p.Q122Q|CLCN6_uc009vnh.1_Silent_p.Q122Q|CLCN6_uc010oat.1_5'UTR|CLCN6_uc010oau.1_Silent_p.Q100Q	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	122					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGCAGCCAGAAAGGCTGCC	0.547													0	0	0	0.007835	0	42	93										A	11882771	G	A	11882771	2	1	46	1	0	0	0	0	0	0	0	1	3467	933	33	1		1	CLCN6	1	11882771	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1687693	11882771	237367850	23	11720										
VPS13D	55187	broad.mit.edu	37	chr1	12304593	12304593	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgactcttgtctttgtaGaatgaccgccagcagaaagg	11	9	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:12304593G>A	uc001atv.2	+	5	508	c.367_splice	c.e5-1	p.N123_splice	VPS13D_uc001atw.2_Splice_Site_p.N123_splice	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTCTTTGTAGAATGACCGCC	0.458													0	0	0	0.01441	0	68	82										A	12304593	G	A	12304593	5	1	46	1	0	0	0	0	0	0	1	0	17189	956	33	1	380	1	VPS13D	1	12304593	Splice_Site	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	421822	12304593	236946028	24	11721										
VPS13D	55187	broad.mit.edu	37	chr1	12387712	12387712	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatttctttgaaggccaattGaaaaaggcagcaagttggtt	10	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:12387712G>A	uc001atv.2	+	36	8139	c.7998G>A	c.(7996-7998)TTG>TTA	p.L2666L	VPS13D_uc001atw.2_Silent_p.L2666L|VPS13D_uc001atx.2_Silent_p.L1854L|VPS13D_uc001aty.1_Silent_p.L404L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2666	UBA.				protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAGGCCAATTGAAAAAGGCAG	0.473													0	0	0	0.01441	0	90	249										A	12387712	G	A	12387712	2	1	46	1	0	0	0	0	0	0	0	1	17189	1281	45	1		1	VPS13D	1	12387712	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	83119	12387712	236862909	25	11722										
PRDM2	7799	broad.mit.edu	37	chr1	14105194	14105194	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagaagccagcatgccaaatGaaaattctgtgaaagagcca	9	8	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:14105194G>A	uc001avi.2	+	8	1760	c.904G>A	c.(904-906)GAA>AAA	p.E302K	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.E302K|PRDM2_uc001avj.2_Intron|PRDM2_uc009vod.1_Missense_Mutation_p.E59K|PRDM2_uc001avk.2_Missense_Mutation_p.E101K|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	302	Retinoblastoma protein binding.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CATGCCAAATGAAAATTCTGT	0.234													0	0	0	0.008871	0	21	72										A	14105194	G	A	14105194	3	1	46	1	0	0	0	0	1	0	0	0	12458	1291	45	1	930	1	PRDM2	1	14105194	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1717482	14105194	235145427	26	11723										
DNAJC16	23341	broad.mit.edu	37	chr1	15874821	15874821	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggatatgtatatgtgggtttGagagggacggaagagatgac	17	2	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:15874821G>C	uc001aws.2	+	7	1041	c.921G>C	c.(919-921)TTG>TTC	p.L307F	DNAJC16_uc001awr.1_Missense_Mutation_p.L307F|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	307	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ATGTGGGTTTGAGAGGGACGG	0.398													0	0	0	0.003271	0	35	72										C	15874821	G	C	15874821	3	2	46	1	0	0	0	0	1	0	0	0	4635	1281	45	1	943	1	DNAJC16	1	15874821	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1769627	15874821	233375800	27	11724										
DDI2	84301	broad.mit.edu	37	chr1	15956939	15956939	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagaaataacttcatctcctCagggcttggacaatccagcc	8	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:15956939C>T	uc001awx.1	+	3	484	c.388C>T	c.(388-390)CAG>TAG	p.Q130*	DDI2_uc001aww.2_Nonsense_Mutation_p.Q130*|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	130					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TTCATCTCCTCAGGGCTTGGA	0.562													0	0	0	0.014323	0	24	114										T	15956939	C	T	15956939	4	4	46	1	0	0	0	0	0	1	0	0	4329	827	29	1	398	1	DDI2	1	15956939	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	82118	15956939	233293682	28	11725										
PLEKHM2	23207	broad.mit.edu	37	chr1	16053943	16053943	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgactttagtgaggggctttCagccccaatggacttctacc	10	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16053943C>T	uc010obo.1	+	9	1603	c.1376C>T	c.(1375-1377)TCA>TTA	p.S459L		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	459					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GAGGGGCTTTCAGCCCCAATG	0.632													0	0	0	0.009096	0	4	12										T	16053943	C	T	16053943	3	4	46	1	0	0	0	0	1	0	0	0	12081	838	29	1	1410	1	PLEKHM2	1	16053943	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	97004	16053943	233196678	29	11726										
SPEN	23013	broad.mit.edu	37	chr1	16259146	16259146	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatggtttatcatcccagttGaaaagtgatccagttgatcc	9	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16259146G>A	uc001axk.1	+	11	6615	c.6411G>A	c.(6409-6411)TTG>TTA	p.L2137L	SPEN_uc010obp.1_Silent_p.L2096L	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2137	Interaction with MSX2 (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CATCCCAGTTGAAAAGTGATC	0.557													0	0	0	0.01441	0	75	153										A	16259146	G	A	16259146	2	1	46	1	0	0	0	0	0	0	0	1	15037	1281	45	1		1	SPEN	1	16259146	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	205203	16259146	232991475	30	11727										
SPEN	23013	broad.mit.edu	37	chr1	16259289	16259289	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgcaaagctcgctgaggcctCtgcctctgctgcctataagg	11	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16259289C>T	uc001axk.1	+	11	6758	c.6554C>T	c.(6553-6555)TCT>TTT	p.S2185F	SPEN_uc010obp.1_Missense_Mutation_p.S2144F	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2185	Interaction with MSX2 (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCTGAGGCCTCTGCCTCTGCT	0.622													0	0	0	0.01441	0	57	62										T	16259289	C	T	16259289	3	4	46	1	0	0	0	0	1	0	0	0	15037	913	32	1	6596	1	SPEN	1	16259289	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	143	16259289	232991332	31	11728										
ZBTB17	7709	broad.mit.edu	37	chr1	16269163	16269163	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgccctggtgcacggtcttCacgtgggagcgcaggttgtc	15	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16269163C>T	uc001axl.3	-	14	2138	c.1899G>A	c.(1897-1899)GTG>GTA	p.V633V	ZBTB17_uc010obq.1_Silent_p.V550V|ZBTB17_uc010obr.1_Silent_p.V633V|ZBTB17_uc010obs.1_Silent_p.V557V	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	633	C2H2-type 12.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		GCACGGTCTTCACGTGGGAGC	0.592													0	0	0	0.013726	0	32	29										T	16269163	C	T	16269163	2	4	46	1	0	0	0	0	0	0	0	1	17524	813	29	1		1	ZBTB17	1	16269163	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9874	16269163	232981458	32	11729										
ZBTB17	7709	broad.mit.edu	37	chr1	16269661	16269661	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgtcgtggtggcgaatatGattggccaactggctggact	15	7	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16269661G>A	uc001axl.3	-	13	1965	c.1726C>T	c.(1726-1728)CAT>TAT	p.H576Y	ZBTB17_uc010obq.1_Missense_Mutation_p.H493Y|ZBTB17_uc010obr.1_Missense_Mutation_p.H576Y|ZBTB17_uc010obs.1_Missense_Mutation_p.H500Y	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	576	C2H2-type 10.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCGAATATGATTGGCCAAC	0.587													0	0	0	0.012213	0	29	128										A	16269661	G	A	16269661	3	1	46	1	0	0	0	0	1	0	0	0	17524	1290	45	1	701	1	ZBTB17	1	16269661	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	498	16269661	232980960	33	11730										
CROCC	9696	broad.mit.edu	37	chr1	17257888	17257888	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgaggtgaagatgttcactGagaggtgaggcctggccggg	19	7	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:17257888G>A	uc001azt.2	+	8	1021	c.952G>A	c.(952-954)GAG>AAG	p.E318K	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_Missense_Mutation_p.E81K	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	318	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GATGTTCACTGAGAGGTGAGG	0.587													0	0	0	0.01441	0	79	60										A	17257888	G	A	17257888	3	1	46	1	0	0	0	0	1	0	0	0	3893	1291	45	1	982	1	CROCC	1	17257888	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	988227	17257888	231992733	34	11731										
PADI2	11240	broad.mit.edu	37	chr1	17409048	17409048	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcagcatcttaccaggagctCcttcacagggaagtccttta	8	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:17409048C>T	uc001baf.2	-	10	1232	c.1150G>A	c.(1150-1152)GAG>AAG	p.E384K	PADI2_uc010ocm.1_Missense_Mutation_p.E268K|PADI2_uc001bag.1_Missense_Mutation_p.E384K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	384					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ACCAGGAGCTCCTTCACAGGG	0.483													0	0	0	0.012319	0	21	60										T	17409048	C	T	17409048	3	4	46	1	0	0	0	0	1	0	0	0	11378	864	30	1	875	1	PADI2	1	17409048	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	151160	17409048	231841573	35	11732										
IGSF21	84966	broad.mit.edu	37	chr1	18661457	18661457	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catctacgaccgcgccaccaGggagaaggtggtcctggcat	13	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:18661457G>T	uc001bau.1	+	4	760	c.377G>T	c.(376-378)AGG>ATG	p.R126M		NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	126	Ig-like 1.					extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CGCGCCACCAGGGAGAAGGTG	0.617													1	0	7.48243e-07	0.006214	7.68791e-07	9	22										T	18661457	G	T	18661457	3	4	46	1	0	0	0	0	1	0	0	0	7599	1000	35	4	391	4	IGSF21	1	18661457	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1252409	18661457	230589164	36	11733										
TAS1R2	80834	broad.mit.edu	37	chr1	19186032	19186032	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgcccttcatgttggcatgGagggagaagaggccacccag	14	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:19186032G>C	uc001bba.1	-	1	124	c.123C>G	c.(121-123)CTC>CTG	p.L41L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	41	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGTTGGCATGGAGGGAGAAGA	0.582													0	0	0	0.007835	0	43	45										C	19186032	G	C	19186032	2	2	46	1	0	0	0	0	0	0	0	1	15560	1161	41	1		1	TAS1R2	1	19186032	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	524575	19186032	230064589	37	11734										
UBR4	23352	broad.mit.edu	37	chr1	19510379	19510379	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagagctgcagcaaactcttCatctgatgaaccttaaagac	8	10	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:19510379C>T	uc001bbi.2	-	17	2114	c.2110G>A	c.(2110-2112)GAA>AAA	p.E704K		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	704					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCAAACTCTTCATCTGATGAA	0.443													0	0	0	0.003163	0	15	41										T	19510379	C	T	19510379	3	4	46	1	0	0	0	0	1	0	0	0	16901	835	29	1	13801	1	UBR4	1	19510379	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	324347	19510379	229740242	38	11735										
KIAA0090	23065	broad.mit.edu	37	chr1	19559255	19559255	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatggtgccagagctgctctCaatgccaaaaagctgcaaga	11	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:19559255C>G	uc001bbo.2	-	15	1688	c.1645G>C	c.(1645-1647)GAG>CAG	p.E549Q	KIAA0090_uc001bbp.2_Missense_Mutation_p.E548Q|KIAA0090_uc001bbq.2_Missense_Mutation_p.E548Q|KIAA0090_uc001bbr.2_Missense_Mutation_p.E527Q	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	549	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		GAGCTGCTCTCAATGCCAAAA	0.438													0	0	0	0.00623	0	38	131										G	19559255	C	G	19559255	3	3	46	1	0	0	0	0	1	0	0	0	8153	835	29	1	1372	1	KIAA0090	1	19559255	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	48876	19559255	229691366	39	11736										
EIF4G3	8672	broad.mit.edu	37	chr1	21167472	21167472	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccactcccactctcacaaaaAcatgtagtaggccctgggca	7	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:21167472A>G	uc001bec.2	-	25	4026	c.3770T>C	c.(3769-3771)GTT>GCT	p.V1257A	EIF4G3_uc010odi.1_Missense_Mutation_p.V861A|EIF4G3_uc010odj.1_Missense_Mutation_p.V1256A|EIF4G3_uc009vpz.2_Missense_Mutation_p.V977A|EIF4G3_uc001bed.2_Missense_Mutation_p.V1257A|EIF4G3_uc001bef.2_Missense_Mutation_p.V1293A|EIF4G3_uc001bee.2_Missense_Mutation_p.V1263A	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1257	MI.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTCACAAAAACATGTAGTAG	0.478													0	0	0	0.007291	0	29	70										G	21167472	A	G	21167472	3	3	46	1	0	0	0	0	1	0	0	0	5038	43	2	5	1019	5	EIF4G3	1	21167472	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1608217	21167472	228083149	40	11737										
HSPG2	3339	broad.mit.edu	37	chr1	22173050	22173050	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctccccttcggccacgtgtGaggaggatgactcaattctg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:22173050G>A	uc001bfj.2	-	63	8247	c.8207C>T	c.(8206-8208)TCA>TTA	p.S2736L	HSPG2_uc009vqd.2_Missense_Mutation_p.S2737L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2736	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGCCACGTGTGAGGAGGATGA	0.622													0	0	0	0.006122	0	18	67										A	22173050	G	A	22173050	3	1	46	1	0	0	0	0	1	0	0	0	7430	1294	45	1	5108	1	HSPG2	1	22173050	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1005578	22173050	227077571	41	11738	54	2								
HSPG2	3339	broad.mit.edu	37	chr1	22173059	22173059	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggccacgtgtgaggaggatGactcaattctgatgggcatg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:22173059G>A	uc001bfj.2	-	63	8238	c.8198C>T	c.(8197-8199)TCA>TTA	p.S2733L	HSPG2_uc009vqd.2_Missense_Mutation_p.S2734L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2733	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGAGGAGGATGACTCAATTCT	0.627													0	0	0	0.004007	0	15	60										A	22173059	G	A	22173059	3	1	46	1	0	0	0	0	1	0	0	0	7430	1294	45	1	5117	1	HSPG2	1	22173059	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	9	22173059	227077562	42	11739	54	2								
HSPG2	3339	broad.mit.edu	37	chr1	22178312	22178312	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagttggccccctgggtcccAgttactgtgaccgtgatgga	13	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:22178312A>T	uc001bfj.2	-	54	7018	c.6978T>A	c.(6976-6978)ACT>ACA	p.T2326T	HSPG2_uc009vqd.2_Silent_p.T2327T	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2326	Ig-like C2-type 8.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCTGGGTCCCAGTTACTGTGA	0.637													0	0	0	0.013537	0	12	37										T	22178312	A	T	22178312	2	4	46	1	0	0	0	0	0	0	0	1	7430	175	7	5		5	HSPG2	1	22178312	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	5253	22178312	227072309	43	11740										
C1orf213	148898	broad.mit.edu	37	chr1	23696057	23696057	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagcccagatatcgtaggctGatcctaaagactcagattcc	8	11	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:23696057G>A	uc001bgw.2	+	1	594	c.267G>A	c.(265-267)CTG>CTA	p.L89L	ZNF436_uc001bgt.2_5'Flank|ZNF436_uc001bgu.2_5'UTR|C1orf213_uc001bgv.2_Intron	NM_138479	NP_612488			hypothetical protein LOC148898 isoform 1												0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.97e-26)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;5.23e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		ATCGTAGGCTGATCCTAAAGA	0.562													0	0	0	0.001168	0	5	30										A	23696057	G	A	23696057	2	1	46	1	0	0	0	0	0	0	0	1	2030	1277	45	1		1	C1orf213	1	23696057	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1517745	23696057	225554564	44	11741										
MYOM3	127294	broad.mit.edu	37	chr1	24406673	24406673	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacctcggatgcccgtacatCgtacggggggcctgtgacaa	13	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:24406673C>T	uc001bin.3	-	20	2582	c.2419G>A	c.(2419-2421)GAT>AAT	p.D807N	MYOM3_uc001bim.3_Missense_Mutation_p.D464N|MYOM3_uc001bio.2_Missense_Mutation_p.D807N	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	807	Fibronectin type-III 5.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCCCGTACATCGTACGGGGGG	0.453													0	0	0	0.00499	0	15	33										T	24406673	C	T	24406673	3	4	46	1	0	0	0	0	1	0	0	0	10093	884	31	1	1966	1	MYOM3	1	24406673	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	710616	24406673	224843948	45	11742										
NIPAL3	57185	broad.mit.edu	37	chr1	24768670	24768670	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgttcgcctcctacgccttCgcgccgctgtcactcatcgt	9	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:24768670C>T	uc001bjh.2	+	4	695	c.288C>T	c.(286-288)TTC>TTT	p.F96F	NIPAL3_uc010oek.1_Silent_p.F96F|NIPAL3_uc001bjg.2_Silent_p.F96F|NIPAL3_uc009vrc.2_Silent_p.F14F	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	96	Helical; (Potential).					integral to membrane					0						CCTACGCCTTCGCGCCGCTGT	0.632													0	0	0	0.010504	0	19	75										T	24768670	C	T	24768670	2	4	46	1	0	0	0	0	0	0	0	1	10426	883	31	1		1	NIPAL3	1	24768670	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	361997	24768670	224481951	46	11743										
PAQR7	164091	broad.mit.edu	37	chr1	26190213	26190213	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtacggcttccagaagagcgGcggcacctcagctcgatcca	12	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:26190213G>A	uc001bkx.2	-	2	785	c.118C>T	c.(118-120)CCG>TCG	p.P40S		NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	40	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		CAGAAGAGCGGCGGCACCTCA	0.622													0	0	0	0.00499	0	15	28										A	26190213	G	A	26190213	3	1	46	1	0	0	0	0	1	0	0	0	11440	1203	42	2	926	2	PAQR7	1	26190213	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1421543	26190213	223060408	47	11744										
CNKSR1	10256	broad.mit.edu	37	chr1	26509694	26509694	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgcctctgcagggcctaGaaattcacaccaccagcaat	7	15	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:26509694G>A	uc001bln.3	+	7	689	c.631G>A	c.(631-633)GAA>AAA	p.E211K	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.E211K|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	211	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGGCCTAGAAATTCACAC	0.627													0	0	0	0.01441	0	105	117										A	26509694	G	A	26509694	3	1	46	1	0	0	0	0	1	0	0	0	3606	943	33	1	657	1	CNKSR1	1	26509694	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	319481	26509694	222740927	48	11745										
PIGV	55650	broad.mit.edu	37	chr1	27121287	27121287	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttggccttccctttgccctCtttcagtattatgcctacac	5	15	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27121287C>T	uc001bmz.2	+	3	1093	c.762C>T	c.(760-762)CTC>CTT	p.L254L	PIGV_uc001bmy.2_Intron|PIGV_uc009vso.2_Silent_p.L254L|PIGV_uc010ofg.1_Intron|PIGV_uc001bna.2_Silent_p.L254L	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	254	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CCTTTGCCCTCTTTCAGTATT	0.502													0	0	0	0.01441	0	46	130										T	27121287	C	T	27121287	2	4	46	1	0	0	0	0	0	0	0	1	11901	900	32	1		1	PIGV	1	27121287	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	611593	27121287	222129334	49	11746										
PIGV	55650	broad.mit.edu	37	chr1	27124267	27124267	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccagtcacacgatacattCtaggctacttcctgacttac	5	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27124267C>T	uc001bmz.2	+	4	1745	c.1414C>T	c.(1414-1416)CTA>TTA	p.L472L	PIGV_uc001bmy.2_Silent_p.L237L|PIGV_uc009vso.2_Missense_Mutation_p.S465F|PIGV_uc010ofg.1_Silent_p.L237L|PIGV_uc001bna.2_Silent_p.L472L	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	472	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		ACGATACATTCTAGGCTACTT	0.502													0	0	0	0.012319	0	19	62										T	27124267	C	T	27124267	2	4	46	1	0	0	0	0	0	0	0	1	11901	912	32	1		1	PIGV	1	27124267	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2980	27124267	222126354	50	11747										
FCN3	8547	broad.mit.edu	37	chr1	27700864	27700864	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccttgaggacctggggctCccttctccccaggacttcct	9	17	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27700864C>A	uc001boa.2	-	2	176	c.170G>T	c.(169-171)GGA>GTA	p.G57V	FCN3_uc001bob.2_Missense_Mutation_p.G57V	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	57	Collagen-like.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCTGGGGCTCCCTTCTCCCC	0.612													1	0	0.00010058	0.013537	0.000102565	11	29										A	27700864	C	A	27700864	3	1	46	1	0	0	0	0	1	0	0	0	5793	855	30	3	757	3	FCN3	1	27700864	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	576597	27700864	221549757	51	11748										
AHDC1	27245	broad.mit.edu	37	chr1	27875316	27875316	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaaaggccactgagaagccCccgcaaactgccgacagttc	11	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27875316C>A	uc009vsy.2	-	6	4280	c.3311G>T	c.(3310-3312)GGG>GTG	p.G1104V	AHDC1_uc009vsz.1_Missense_Mutation_p.G1104V	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1104							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CTGAGAAGCCCCCGCAAACTG	0.567													1	0	3.86212e-05	0.008291	3.94205e-05	10	49										A	27875316	C	A	27875316	3	1	46	1	0	0	0	0	1	0	0	0	412	623	22	4	1504	4	AHDC1	1	27875316	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	174452	27875316	221375305	52	11749										
FGR	2268	broad.mit.edu	37	chr1	27939500	27939500	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaaggactgcaggtactcGaaggtaggcctctcctccgg	14	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27939500G>C	uc001boj.2	-	11	1661	c.1515C>G	c.(1513-1515)TTC>TTG	p.F505L	FGR_uc001boi.2_Missense_Mutation_p.F208L|FGR_uc001bok.2_Missense_Mutation_p.F505L|FGR_uc001bol.2_Missense_Mutation_p.F505L|FGR_uc001bom.2_Missense_Mutation_p.F505L	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	505	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCAGGTACTCGAAGGTAGGCC	0.622													0	0	0	0.004482	0	8	36										C	27939500	G	C	27939500	3	2	46	1	0	0	0	0	1	0	0	0	5874	1049	37	1	78	1	FGR	1	27939500	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	64184	27939500	221311121	53	11750										
FGR	2268	broad.mit.edu	37	chr1	27950343	27950343	+	Missense_Mutation	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccatagtggtctgctgcccCgtagcttctgaagtcccctt							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27950343C>T	uc001boj.2	-	1	231	c.85G>A	c.(85-87)GGG>AGG	p.G29R	FGR_uc001bok.2_Missense_Mutation_p.G29R|FGR_uc001bol.2_Missense_Mutation_p.G29R|FGR_uc001bom.2_Missense_Mutation_p.G29R	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	29					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGCTGCCCCGTAGCTTCTG	0.587													0	0	0	0.010729	0	12	26										T	27950343	C	T	27950343	3	4	46	1	0	0	0	0	1	0	0	0	5874	652	23	2	1548	2	FGR	1	27950343	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	10843	27950343	221300278	54	11751	55	2								
FGR	2268	broad.mit.edu	37	chr1	27950351	27950351	+	Missense_Mutation	SNP	C	C	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtctgctgccccgtagcttCtgaagtccccttccaggcca							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27950351C>A	uc001boj.2	-	1	223	c.77G>T	c.(76-78)AGA>ATA	p.R26I	FGR_uc001bok.2_Missense_Mutation_p.R26I|FGR_uc001bol.2_Missense_Mutation_p.R26I|FGR_uc001bom.2_Missense_Mutation_p.R26I	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	26					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCCGTAGCTTCTGAAGTCCCC	0.587													1	0	4.3838e-07	0.001855	4.5106e-07	13	25										A	27950351	C	A	27950351	3	1	46	1	0	0	0	0	1	0	0	0	5874	913	32	3	1556	3	FGR	1	27950351	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	8	27950351	221300270	55	11752	55	2								
C1orf38	9473	broad.mit.edu	37	chr1	28206495	28206495	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccctgaaagacctcgtcctCacctgccccaccctgccctg	7	21	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:28206495C>T	uc001bpc.3	+	3	604	c.576C>T	c.(574-576)CTC>CTT	p.L192L	C1orf38_uc001boz.2_Silent_p.L192L|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Silent_p.L192L	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	192	CABIT 1.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTCGTCCTCACCTGCCCCA	0.617													0	0	0	0.009096	0	4	8										T	28206495	C	T	28206495	2	4	46	1	0	0	0	0	0	0	0	1	2039	813	29	1		1	C1orf38	1	28206495	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	256144	28206495	221044126	56	11753										
RAB42	115273	broad.mit.edu	37	chr1	28920495	28920495	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcctttgacaccctcgctGatgctatccagcaggccctg	10	15	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:28920495G>A	uc001bqu.2	+	2	490	c.184G>A	c.(184-186)GAT>AAT	p.D62N	RAB42_uc001bqv.2_Missense_Mutation_p.D62N	NM_152304	NP_689517	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	62					small GTPase mediated signal transduction	membrane	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		CACCCTCGCTGATGCTATCCA	0.617													0	0	0	0.014323	0	23	11										A	28920495	G	A	28920495	3	1	46	1	0	0	0	0	1	0	0	0	12944	1290	45	1	186	1	RAB42	1	28920495	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	714000	28920495	220330126	57	11754										
SPOCD1	90853	broad.mit.edu	37	chr1	32279666	32279666	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actggacctttcttcaggttCttagtgcccttggatcttct	8	11	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:32279666C>G	uc001bts.1	-	2	1327	c.1269G>C	c.(1267-1269)AAG>AAC	p.K423N	SPOCD1_uc001btu.2_Missense_Mutation_p.K423N|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	423					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCTTCAGGTTCTTAGTGCCCT	0.622													0	0	0	0.010818	0	30	37										G	32279666	C	G	32279666	3	3	46	1	0	0	0	0	1	0	0	0	15077	912	32	1	2441	1	SPOCD1	1	32279666	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3359171	32279666	216970955	58	11755										
CCDC28B	79140	broad.mit.edu	37	chr1	32670814	32670814	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccagaagctgcacctggccGagaacgccgagcctgaggag	15	13	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:32670814G>A	uc001bul.1	+	6	700	c.568G>A	c.(568-570)GAG>AAG	p.E190K	CCDC28B_uc001buk.2_3'UTR|IQCC_uc001bum.2_5'Flank|IQCC_uc009vua.2_5'Flank|IQCC_uc010ogz.1_5'Flank	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	190											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCACCTGGCCGAGAACGCCGA	0.607													0	0	0	0.009096	0	4	16										A	32670814	G	A	32670814	3	1	46	1	0	0	0	0	1	0	0	0	2803	1059	37	1	586	1	CCDC28B	1	32670814	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	391148	32670814	216579807	59	11756										
YARS	8565	broad.mit.edu	37	chr1	33245125	33245125	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctggcggtttatcccttctCtgggaagacacaggacaaga	11	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:33245125C>T	uc001bvy.1	-	12	2123	c.1335_splice	c.e12-1	p.I445_splice	YARS_uc001bvw.1_Splice_Site_p.I105_splice|YARS_uc001bvx.1_Splice_Site_p.I96_splice	NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase						apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TATCCCTTCTCTGGGAAGACA	0.562													0	0	0	0.007413	0	20	47										T	33245125	C	T	33245125	5	4	46	1	0	0	0	0	0	0	1	0	17464	927	32	1	260	1	YARS	1	33245125	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	574311	33245125	216005496	60	11757										
YARS	8565	broad.mit.edu	37	chr1	33252626	33252626	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggctcacagaaggccttcttCagttttttcttcacatcctc	6	13	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:33252626C>T	uc001bvy.1	-	7	1523	c.735G>A	c.(733-735)CTG>CTA	p.L245L		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	245					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	AGGCCTTCTTCAGTTTTTTCT	0.443													0	0	0	0.01441	0	57	45										T	33252626	C	T	33252626	2	4	46	1	0	0	0	0	0	0	0	1	17464	813	29	1		1	YARS	1	33252626	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7501	33252626	215997995	61	11758										
ZMYM6	9204	broad.mit.edu	37	chr1	35476590	35476590	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaaccacttggccctgagaCaggggcaccgccgaagagtt	12	13	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:35476590C>T	uc001byh.2	-	9	1338	c.1110G>A	c.(1108-1110)CTG>CTA	p.L370L	ZMYM6_uc001byf.1_Silent_p.L370L|ZMYM6_uc010oht.1_Silent_p.L273L|ZMYM6_uc009vup.2_Silent_p.L176L|ZMYM6_uc009vuq.1_Silent_p.L370L|ZMYM6_uc009vur.1_Silent_p.L176L	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	370	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GGCCCTGAGACAGGGGCACCG	0.478													0	0	0	0.008871	0	17	51										T	35476590	C	T	35476590	2	4	46	1	0	0	0	0	0	0	0	1	17701	465	17	2		2	ZMYM6	1	35476590	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2223964	35476590	213774031	62	11759										
ZMYM1	79830	broad.mit.edu	37	chr1	35575944	35575944	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgcaaaccattgaagccctCagatgaaatgattgagacta	8	8	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:35575944C>T	uc001bym.2	+	8	1005	c.857C>T	c.(856-858)TCA>TTA	p.S286L	ZMYM1_uc001byn.2_Missense_Mutation_p.S286L|ZMYM1_uc010ohu.1_Missense_Mutation_p.S286L|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.S211L	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	286						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTGAAGCCCTCAGATGAAATG	0.353													0	0	0	0.012213	0	34	118										T	35575944	C	T	35575944	3	4	46	1	0	0	0	0	1	0	0	0	17696	838	29	1	879	1	ZMYM1	1	35575944	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	99354	35575944	213674677	63	11760										
KIAA0319L	79932	broad.mit.edu	37	chr1	35972601	35972601	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accaaaagacatggcaggcaGagtcctggcagcaggcagcc	13	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:35972601G>C	uc001byx.2	-	3	536	c.278C>G	c.(277-279)TCT>TGT	p.S93C	KIAA0319L_uc010ohw.1_RNA|KIAA0319L_uc001byz.2_Missense_Mutation_p.S93C|KIAA0319L_uc010ohx.1_Missense_Mutation_p.S93C	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	93	MANSC.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGGCAGGCAGAGTCCTGGCA	0.562													0	0	0	0.010729	0	7	29										C	35972601	G	C	35972601	3	2	46	1	0	0	0	0	1	0	0	0	8169	942	33	1	2947	1	KIAA0319L	1	35972601	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	396657	35972601	213278020	64	11761										
C1orf216	127703	broad.mit.edu	37	chr1	36181317	36181317	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggttgtctaggatggtgtcGaagctctcctgcagtcgggc	15	10	2	0	rs11554216		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:36181317G>A	uc001bzh.1	-	2	1094	c.606C>T	c.(604-606)TTC>TTT	p.F202F		NM_152374	NP_689587	Q8TAB5	CA216_HUMAN	hypothetical protein LOC127703	202										skin(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGATGGTGTCGAAGCTCTCCT	0.607											OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	31	90										A	36181317	G	A	36181317	2	1	46	1	0	0	0	0	0	0	0	1	2031	1049	37	1		1	C1orf216	1	36181317	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	208716	36181317	213069304	65	11762										
MAP7D1	55700	broad.mit.edu	37	chr1	36643602	36643602	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccccgaggcaccactgcatCccccaaggggcgggttcgga	13	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:36643602C>A	uc001bzz.2	+	9	1724	c.1508C>A	c.(1507-1509)TCC>TAC	p.S503Y	MAP7D1_uc001caa.2_Missense_Mutation_p.S471Y|MAP7D1_uc001cab.2_Missense_Mutation_p.S466Y|MAP7D1_uc001cac.2_Missense_Mutation_p.S203Y|MAP7D1_uc001cad.2_Missense_Mutation_p.S49Y	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	503	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				ACCACTGCATCCCCCAAGGGG	0.701													1	0	0.00116845	0.001168	0.00118816	5	22										A	36643602	C	A	36643602	3	1	46	1	0	0	0	0	1	0	0	0	9267	855	30	3	1542	3	MAP7D1	1	36643602	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	462285	36643602	212607019	66	11763										
RHBDL2	54933	broad.mit.edu	37	chr1	39352269	39352269	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atccaaaaccttggatctttCagcagtgctttatcaaagca	6	10	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39352269C>T	uc001ccu.1	-	8	1047	c.819G>A	c.(817-819)CTG>CTA	p.L273L	RHBDL2_uc010oin.1_3'UTR|RHBDL2_uc010oio.1_Silent_p.L353L	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	273					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTGGATCTTTCAGCAGTGCTT	0.433													0	0	0	0.00632	0	28	94										T	39352269	C	T	39352269	2	4	46	1	0	0	0	0	0	0	0	1	13322	813	29	1		1	RHBDL2	1	39352269	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2708667	39352269	209898352	67	11764										
MACF1	23499	broad.mit.edu	37	chr1	39757669	39757669	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcacatccatacgagtgtaGaagagctgggctcaagtgtc	12	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39757669G>A	uc010ois.1	+	17	2093	c.1888G>A	c.(1888-1890)GAA>AAA	p.E630K	MACF1_uc001cda.1_Missense_Mutation_p.E538K	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	630					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TACGAGTGTAGAAGAGCTGGG	0.507													0	0	0	0.003954	0	27	30										A	39757669	G	A	39757669	3	1	46	1	0	0	0	0	1	0	0	0	9144	943	33	1	1946	1	MACF1	1	39757669	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	405400	39757669	209492952	68	11765										
MACF1	23499	broad.mit.edu	37	chr1	39919397	39919397	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaattcatgaagaaagtaGaagaaaagcgagtggacgtt	13	3	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39919397G>C	uc010oiu.1	+	53	16221	c.16090G>C	c.(16090-16092)GAA>CAA	p.E5364Q	MACF1_uc010ois.1_Missense_Mutation_p.E4862Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGAAAGTAGAAGAAAAGCG	0.413													0	0	0	0.01441	0	92	84										C	39919397	G	C	39919397	3	2	46	1	0	0	0	0	1	0	0	0	9144	943	33	1	21069	1	MACF1	1	39919397	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	161728	39919397	209331224	69	11766										
MACF1	23499	broad.mit.edu	37	chr1	39950348	39950348	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcggacatcccttgctggtGataccagcaatagttcttcc	9	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39950348G>A	uc010oiu.1	+	63	17637	c.17506G>A	c.(17506-17508)GAT>AAT	p.D5836N	MACF1_uc010ois.1_Missense_Mutation_p.D5328N|MACF1_uc001cde.1_Missense_Mutation_p.D242N|MACF1_uc001cdf.1_Missense_Mutation_p.D211N|MACF1_uc001cdg.2_Missense_Mutation_p.D156N|MACF1_uc001cdh.2_Missense_Mutation_p.D119N	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7286	Ser-rich.|C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCTTGCTGGTGATACCAGCAA	0.458													0	0	0	0.007835	0	39	145										A	39950348	G	A	39950348	3	1	46	1	0	0	0	0	1	0	0	0	9144	1290	45	1	22525	1	MACF1	1	39950348	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	30951	39950348	209300273	70	11767										
PABPC4	8761	broad.mit.edu	37	chr1	40041525	40041525	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggacagcacaggccccgcGgggctgaacttttcgtacag	13	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:40041525G>A	uc010oiv.1	-	1	997	c.99C>T	c.(97-99)CCC>CCT	p.P33P	PABPC4_uc001cdl.2_Silent_p.P33P|PABPC4_uc001cdm.2_Silent_p.P33P	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	33	RRM 1.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGGCCCCGCGGGGCTGAACT	0.647													0	0	0	0.001984	0	6	17										A	40041525	G	A	40041525	2	1	46	1	0	0	0	0	0	0	0	1	11366	1103	39	2		2	PABPC4	1	40041525	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	91177	40041525	209209096	71	11768										
ZNF643	65243	broad.mit.edu	37	chr1	40929203	40929203	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaagccttcagctgtagttCatcccttattagacactgca	6	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:40929203C>T	uc001cfn.1	+	5	1844	c.1547C>T	c.(1546-1548)TCA>TTA	p.S516L	ZNF643_uc001cfl.1_Missense_Mutation_p.S414L|ZNF643_uc001cfm.1_Missense_Mutation_p.S382L	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	516	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			AGCTGTAGTTCATCCCTTATT	0.353													0	0	0	0.010504	0	20	73										T	40929203	C	T	40929203	3	4	46	1	0	0	0	0	1	0	0	0	18056	838	29	1	1565	1	ZNF643	1	40929203	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	887678	40929203	208321418	72	11769										
KCNQ4	9132	broad.mit.edu	37	chr1	41283961	41283961	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaaagcccttctgtgtcatCggtaatgaggcgcgccccgc	12	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:41283961C>T	uc001cgh.1	+	3	613	c.531C>T	c.(529-531)ATC>ATT	p.I177I	KCNQ4_uc001cgi.1_Silent_p.I177I	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	177	Helical; Name=Segment S3; (Potential).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TCTGTGTCATCGGTAATGAGG	0.647													0	0	0	0.003755	0	35	41										T	41283961	C	T	41283961	2	4	46	1	0	0	0	0	0	0	0	1	8085	898	31	1		1	KCNQ4	1	41283961	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	354758	41283961	207966660	73	11770										
EDN2	1907	broad.mit.edu	37	chr1	41949827	41949827	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggtgggtgccttgggcatGagatgaggacgctggctgct	18	7	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:41949827G>A	uc001cgx.2	-	2	184	c.112C>T	c.(112-114)CAT>TAT	p.H38Y	EDN2_uc001cgu.2_RNA|EDN2_uc001cgv.2_RNA|EDN2_uc009vwh.2_5'UTR|EDN2_uc001cgw.2_RNA|EDN2_uc009vwi.2_RNA|EDN2_uc009vwj.2_RNA	NM_001956	NP_001947	P20800	EDN2_HUMAN	endothelin 2 preproprotein	38					artery smooth muscle contraction|calcium-mediated signaling|cytokine-mediated signaling pathway|elevation of cytosolic calcium ion concentration|hormonal regulation of the force of heart contraction|inositol phosphate-mediated signaling|macrophage activation|macrophage chemotaxis|neutrophil chemotaxis|positive regulation of cell proliferation|positive regulation of heart rate|positive regulation of leukocyte chemotaxis|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of the force of heart contraction by chemical signal|prostaglandin biosynthetic process|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space	endothelin B receptor binding|hormone activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTTGGGCATGAGATGAGGAC	0.627													0	0	0	0.013537	0	12	22										A	41949827	G	A	41949827	3	1	46	1	0	0	0	0	1	0	0	0	4917	1290	45	1	440	1	EDN2	1	41949827	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	665866	41949827	207300794	74	11771										
FOXJ3	22887	broad.mit.edu	37	chr1	42647606	42647606	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctgccatcgttgttcctgGagtgctgagtgcctgtggga	14	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:42647606G>C	uc001che.2	-	14	2047	c.1735C>G	c.(1735-1737)CCA>GCA	p.P579A	FOXJ3_uc001chf.2_Missense_Mutation_p.P579A|FOXJ3_uc001chg.2_Missense_Mutation_p.P579A	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	579					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTTGTTCCTGGAGTGCTGAGT	0.403													0	0	0	0.001984	0	7	25										C	42647606	G	C	42647606	3	2	46	1	0	0	0	0	1	0	0	0	6013	1174	41	1	141	1	FOXJ3	1	42647606	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	697779	42647606	206603015	75	11772										
FOXJ3	22887	broad.mit.edu	37	chr1	42671497	42671497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgaaataatacactccattCccaaagaatctgaatctatg	4	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:42671497C>T	uc001che.2	-	8	878	c.566G>A	c.(565-567)GGA>GAA	p.G189E	FOXJ3_uc001chf.2_Missense_Mutation_p.G189E|FOXJ3_uc001chg.2_Missense_Mutation_p.G189E|FOXJ3_uc001chh.1_Intron	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	189					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACACTCCATTCCCAAAGAATC	0.318													0	0	0	0.004289	0	33	38										T	42671497	C	T	42671497	3	4	46	1	0	0	0	0	1	0	0	0	6013	855	30	1	1334	1	FOXJ3	1	42671497	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	23891	42671497	206579124	76	11773										
ZMYND12	84217	broad.mit.edu	37	chr1	42921666	42921666	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccagtgggtagatcacattCatggtgcagccagcagtgct	13	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:42921666C>T	uc001chj.2	-	1	273	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ZMYND12_uc010ojt.1_5'UTR|PPCS_uc001chk.2_5'Flank|PPCS_uc001chl.2_5'Flank	NM_032257	NP_115633	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12 isoform 1	1						intracellular	zinc ion binding			ovary(1)	1	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGATCACATTCATGGTGCAGC	0.637													0	0	0	0.009096	0	4	16										T	42921666	C	T	42921666	3	4	46	1	0	0	0	0	1	0	0	0	17704	826	29	1	1126	1	ZMYND12	1	42921666	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	250169	42921666	206328955	77	11774										
LEPRE1	64175	broad.mit.edu	37	chr1	43213045	43213045	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggttttcagtgcctgaagaGaatcccacggctcttccaca	10	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:43213045G>A	uc001chv.2	-	14	2066	c.1953C>T	c.(1951-1953)TTC>TTT	p.F651F	LEPRE1_uc001chw.2_Silent_p.F651F|LEPRE1_uc001chx.3_Silent_p.F651F	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	651	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGCCTGAAGAGAATCCCACGG	0.592											OREG0013422	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	20	50										A	43213045	G	A	43213045	2	1	46	1	0	0	0	0	0	0	0	1	8729	933	33	1		1	LEPRE1	1	43213045	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	291379	43213045	206037576	78	11775										
PTPRF	5792	broad.mit.edu	37	chr1	44019601	44019601	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caacactagtgccaagctctCagtgctcgaaggtacgtgct	10	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:44019601C>T	uc001cjr.2	+	5	708	c.368C>T	c.(367-369)TCA>TTA	p.S123L	PTPRF_uc001cjq.3_Missense_Mutation_p.S123L|PTPRF_uc001cjs.2_Missense_Mutation_p.S123L|PTPRF_uc001cjt.3_Missense_Mutation_p.S123L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	123	Extracellular (Potential).|Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.G123E(1)		ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCAAGCTCTCAGTGCTCGAA	0.602													0	0	0	0.013537	0	12	19										T	44019601	C	T	44019601	3	4	46	1	0	0	0	0	1	0	0	0	12801	838	29	1	378	1	PTPRF	1	44019601	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	806556	44019601	205231020	79	11776										
SLC6A9	6536	broad.mit.edu	37	chr1	44477385	44477385	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaaggatctctgaacagggaGaagcgtcacctgcaggggag	16	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:44477385G>A	uc001cll.2	-	2	289	c.97C>T	c.(97-99)CTC>TTC	p.L33F	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|SLC6A9_uc001clm.2_Intron|SLC6A9_uc009vxd.2_Intron|SLC6A9_uc010okn.1_Intron|SLC6A9_uc001cln.2_Intron|SLC6A9_uc010oko.1_Intron|SLC6A9_uc010okp.1_Intron	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	33	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	TGAACAGGGAGAAGCGTCACC	0.602													0	0	0	0.00245	0	14	48										A	44477385	G	A	44477385	3	1	46	1	0	0	0	0	1	0	0	0	14691	942	33	1	2075	1	SLC6A9	1	44477385	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	457784	44477385	204773236	80	11777										
BEST4	266675	broad.mit.edu	37	chr1	45251772	45251772	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagtagacagagagcgatatCgtcacgtattcgcccgtccc	10	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:45251772C>T	uc001cmm.2	-	4	659	c.610G>A	c.(610-612)GAT>AAT	p.D204N		NM_153274	NP_695006	Q8NFU0	BEST4_HUMAN	bestrophin 4	204	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGAGCGATATCGTCACGTATT	0.502											OREG0013447	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	72	89										T	45251772	C	T	45251772	3	4	46	1	0	0	0	0	1	0	0	0	1407	884	31	1	835	1	BEST4	1	45251772	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	774387	45251772	203998849	81	11778										
PLK3	1263	broad.mit.edu	37	chr1	45266717	45266717	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcatcgcagatcctaaatGagattgagctgcaccgagac	9	12	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:45266717G>A	uc001cmn.2	+	3	428	c.328G>A	c.(328-330)GAG>AAG	p.E110K	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	110	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					GATCCTAAATGAGATTGAGCT	0.587													0	0	0	0.006214	0	10	15										A	45266717	G	A	45266717	3	1	46	1	0	0	0	0	1	0	0	0	12097	1291	45	1	338	1	PLK3	1	45266717	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14945	45266717	203983904	82	11779										
NASP	4678	broad.mit.edu	37	chr1	46073665	46073665	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcagctgtagaggctggatCagaagtctctgaaaagcctg	12	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:46073665C>T	uc001coi.1	+	6	1184	c.1082C>T	c.(1081-1083)TCA>TTA	p.S361L	NASP_uc010olq.1_Missense_Mutation_p.S324L|NASP_uc001coh.1_Missense_Mutation_p.S363L|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Missense_Mutation_p.S297L|NASP_uc001cok.1_Missense_Mutation_p.S244L	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	361	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GAGGCTGGATCAGAAGTCTCT	0.527													0	0	0	0.008291	0	7	80										T	46073665	C	T	46073665	3	4	46	1	0	0	0	0	1	0	0	0	10172	838	29	1	1181	1	NASP	1	46073665	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	806948	46073665	203176956	83	11780										
IPP	3652	broad.mit.edu	37	chr1	46211827	46211827	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctagaagtatctgaaagattCctgcttcaattcctagaatc	6	9	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:46211827C>A	uc001cou.2	-	2	524	c.257G>T	c.(256-258)GGA>GTA	p.G86V	IPP_uc001cos.3_Missense_Mutation_p.G86V	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	86	BTB.					actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CTGAAAGATTCCTGCTTCAAT	0.358													1	0	5.03518e-11	0.007413	5.25558e-11	19	55										A	46211827	C	A	46211827	3	1	46	1	0	0	0	0	1	0	0	0	7800	855	30	3	1631	3	IPP	1	46211827	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	138162	46211827	203038794	84	11781										
MKNK1	8569	broad.mit.edu	37	chr1	47024307	47024307	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctgggccagggcccgtctCcgggccaggcgtgacttgca	16	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:47024307C>T	uc001cqb.2	-	14	1582	c.1338G>A	c.(1336-1338)CGG>CGA	p.R446R	MKNK1_uc010omd.1_Silent_p.R310R|MKNK1_uc001cqc.2_Silent_p.R405R|MKNK1_uc009vyi.2_3'UTR|MKNK1_uc010ome.1_3'UTR	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	446					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					GGGCCCGTCTCCGGGCCAGGC	0.627													0	0	0	0.00333	0	23	27										T	47024307	C	T	47024307	2	4	46	1	0	0	0	0	0	0	0	1	9604	842	30	1		1	MKNK1	1	47024307	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	812480	47024307	202226314	85	11782										
CYP4Z1	199974	broad.mit.edu	37	chr1	47564903	47564903	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagtaccctgagcatcagcaGagatgccgagatgaaatcag	11	9	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:47564903G>A	uc001cqu.1	+	8	1017	c.1014G>A	c.(1012-1014)CAG>CAA	p.Q338Q		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	338	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						AGCATCAGCAGAGATGCCGAG	0.453													0	0	0	0.00333	0	24	60										A	47564903	G	A	47564903	2	1	46	1	0	0	0	0	0	0	0	1	4194	933	33	1		1	CYP4Z1	1	47564903	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	540596	47564903	201685718	86	11783										
NRD1	4898	broad.mit.edu	37	chr1	52344197	52344197	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcgcaccgaccccgcgtttCgattccccagagcgccgcga	10	18	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:52344197C>T	uc001ctc.3	-	1	413	c.91G>A	c.(91-93)GAA>AAA	p.E31K	NRD1_uc001ctd.3_Missense_Mutation_p.E31K|NRD1_uc001cte.2_5'Flank|NRD1_uc001ctf.2_Missense_Mutation_p.E31K|NRD1_uc010ong.1_Intron|NRD1_uc009vzc.1_5'Flank	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	31					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						CCCCGCGTTTCGATTCCCCAG	0.612													0	0	0	0.001168	0	6	23										T	52344197	C	T	52344197	3	4	46	1	0	0	0	0	1	0	0	0	10645	893	31	1	3700	1	NRD1	1	52344197	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4779294	52344197	196906424	87	11784										
ZFYVE9	9372	broad.mit.edu	37	chr1	52805846	52805846	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggagactataacaaatgtGaagatattccatggatcaga	9	5	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:52805846G>A	uc001cto.2	+	17	4054	c.3882G>A	c.(3880-3882)GTG>GTA	p.V1294V	ZFYVE9_uc001ctp.2_Silent_p.V1235V	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1294					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TAACAAATGTGAAGATATTCC	0.383													0	0	0	0.007413	0	19	71										A	52805846	G	A	52805846	2	1	46	1	0	0	0	0	0	0	0	1	17668	1277	45	1		1	ZFYVE9	1	52805846	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	461649	52805846	196444775	88	11785										
LRRC42	115353	broad.mit.edu	37	chr1	54428058	54428058	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaatttgatcatagtaactgCaagacagagggctgggctga	13	6	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:54428058C>T	uc001cwj.1	+	6	1103	c.903C>T	c.(901-903)TGC>TGT	p.C301C	LRRC42_uc001cwl.1_Silent_p.C301C|LRRC42_uc001cwk.1_Silent_p.C301C|LRRC42_uc009vzm.1_Silent_p.C301C	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	301											0						ATAGTAACTGCAAGACAGAGG	0.453													0	0	0	0.001168	0	6	24										T	54428058	C	T	54428058	2	4	46	1	0	0	0	0	0	0	0	1	9000	718	25	2		2	LRRC42	1	54428058	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1622212	54428058	194822563	89	11786										
DHCR24	1718	broad.mit.edu	37	chr1	55352603	55352603	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgctgctcgtgcaggcgcgGagcgctgctgagcttgaaca	16	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:55352603G>A	uc001cyc.1	-	1	319	c.190C>T	c.(190-192)CCG>TCG	p.P64S	DHCR24_uc010ook.1_5'Flank	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	64	FAD-binding PCMH-type.				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						TGCAGGCGCGGAGCGCTGCTG	0.682													0	0	0	0.000602	0	5	11										A	55352603	G	A	55352603	3	1	46	1	0	0	0	0	1	0	0	0	4476	1174	41	1	1396	1	DHCR24	1	55352603	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	924545	55352603	193898018	90	11787										
DHCR24	1718	broad.mit.edu	37	chr1	55352654	55352654	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgcacgtagtagtagatatCgaagataagcgagagcggca	14	7	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:55352654C>T	uc001cyc.1	-	1	268	c.139G>A	c.(139-141)GAT>AAT	p.D47N	DHCR24_uc010ook.1_5'Flank	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	47	Helical; (Potential).				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						TAGTAGATATCGAAGATAAGC	0.632													0	0	0	0.004482	0	6	14										T	55352654	C	T	55352654	3	4	46	1	0	0	0	0	1	0	0	0	4476	884	31	1	1447	1	DHCR24	1	55352654	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	51	55352654	193897967	91	11788										
C8A	731	broad.mit.edu	37	chr1	57320598	57320598	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgctgttgttttcttcatCttgtctttgatgacttgtca	7	7	5	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:57320598C>T	uc001cyo.2	+	1	156	c.24C>T	c.(22-24)ATC>ATT	p.I8I		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	8					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TTTTCTTCATCTTGTCTTTGA	0.433													0	0	0	0.00245	0	14	13										T	57320598	C	T	57320598	2	4	46	1	0	0	0	0	0	0	0	1	2416	903	32	1		1	C8A	1	57320598	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1967944	57320598	191930023	92	11789										
DOCK7	85440	broad.mit.edu	37	chr1	63113920	63113920	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaagtgaatttttcaagtCaaagatactacaggcccagc	9	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:63113920C>G	uc001daq.2	-	6	623	c.589G>C	c.(589-591)GAC>CAC	p.D197H	DOCK7_uc001dan.2_Missense_Mutation_p.D89H|DOCK7_uc001dao.2_Missense_Mutation_p.D89H|DOCK7_uc001dap.2_Missense_Mutation_p.D197H|DOCK7_uc009wah.1_Missense_Mutation_p.D197H	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	197					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TTTTTCAAGTCAAAGATACTA	0.363													0	0	0	0.014323	0	24	82										G	63113920	C	G	63113920	3	3	46	1	0	0	0	0	1	0	0	0	4692	826	29	1	5916	1	DOCK7	1	63113920	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5793322	63113920	186136701	93	11790										
ITGB3BP	23421	broad.mit.edu	37	chr1	63920112	63920112	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgcacaggagattccaatGagattttcaagctctctact	8	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:63920112G>A	uc001dba.1	-	6	397	c.366C>T	c.(364-366)CTC>CTT	p.L122L	ITGB3BP_uc001dbb.1_Silent_p.L161L|ITGB3BP_uc001dbc.1_RNA|ITGB3BP_uc001dbd.1_RNA|ITGB3BP_uc009wak.1_Silent_p.L144L|ITGB3BP_uc001dbe.1_Silent_p.L35L	NM_014288	NP_055103	Q13352	CENPR_HUMAN	integrin beta 3 binding protein	122					apoptosis|cell adhesion|CenH3-containing nucleosome assembly at centromere|induction of apoptosis by extracellular signals|mitotic prometaphase|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome, centromeric region|cytosol|membrane fraction|nucleoplasm	protein C-terminus binding|signal transducer activity				0						AGATTCCAATGAGATTTTCAA	0.343													0	0	0	0.00245	0	15	53										A	63920112	G	A	63920112	2	1	46	1	0	0	0	0	0	0	0	1	7896	1277	45	1		1	ITGB3BP	1	63920112	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	806192	63920112	185330509	94	11791										
ROR1	4919	broad.mit.edu	37	chr1	64643416	64643416	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggatctccatgagttcctCatcatgagatccccacactc	8	14	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:64643416C>T	uc001dbj.2	+	9	2091	c.1692C>T	c.(1690-1692)CTC>CTT	p.L564L	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	564	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						ATGAGTTCCTCATCATGAGAT	0.483													0	0	0	0.00623	0	39	42										T	64643416	C	T	64643416	2	4	46	1	0	0	0	0	0	0	0	1	13526	813	29	1		1	ROR1	1	64643416	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	723304	64643416	184607205	95	11792										
WDR78	79819	broad.mit.edu	37	chr1	67299731	67299731	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gattcttccatctgctgataTagaaactagtatttctcttt	5	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:67299731T>A	uc001dcx.2	-	12	1890	c.1834A>T	c.(1834-1836)ATA>TTA	p.I612L	WDR78_uc009waw.2_Missense_Mutation_p.I358L|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	612	WD 2.									ovary(2)	2						TCTGCTGATATAGAAACTAGT	0.363													0	0	0	0.00632	0	29	67										A	67299731	T	A	67299731	3	1	46	1	0	0	0	0	1	0	0	0	17325	1406	49	5	736	5	WDR78	1	67299731	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2656315	67299731	181950890	96	11793										
C1orf141	400757	broad.mit.edu	37	chr1	67559011	67559011	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttcttctttagtttatcatCtacagttgtgtggcccgctt	7	9	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:67559011C>G	uc001ddl.1	-	7	991	c.880G>C	c.(880-882)GAT>CAT	p.D294H	C1orf141_uc001ddm.1_Missense_Mutation_p.D294H|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	294										ovary(1)	1						AGTTTATCATCTACAGTTGTG	0.333													0	0	0	0.012213	0	34	118										G	67559011	C	G	67559011	3	3	46	1	0	0	0	0	1	0	0	0	2001	913	32	1	326	1	C1orf141	1	67559011	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	259280	67559011	181691610	97	11794										
PTGER3	5733	broad.mit.edu	37	chr1	71512801	71512801	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgatggccagcgcccgctCgacggccatggcgctggcga	15	16	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:71512801C>T	uc001dfg.1	-	1	691	c.460G>A	c.(460-462)GAG>AAG	p.E154K	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.E154K|PTGER3_uc001dfl.1_Missense_Mutation_p.E154K|PTGER3_uc009wbm.1_Missense_Mutation_p.E154K|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.E154K|PTGER3_uc009wbn.1_Missense_Mutation_p.E154K|PTGER3_uc009wbo.2_Missense_Mutation_p.E154K|PTGER3_uc001dfo.2_Missense_Mutation_p.E154K|PTGER3_uc001dfp.1_Missense_Mutation_p.E154K|PTGER3_uc001dfq.2_Missense_Mutation_p.E154K|uc001dfr.2_RNA	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	154	Cytoplasmic (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	AGCGCCCGCTCGACGGCCATG	0.677													0	0	0	0.006214	0	9	4										T	71512801	C	T	71512801	3	4	46	1	0	0	0	0	1	0	0	0	12744	893	31	1	1031	1	PTGER3	1	71512801	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3953790	71512801	177737820	98	11795										
PIGK	10026	broad.mit.edu	37	chr1	77588010	77588010	+	Frame_Shift_Del	DEL	C	C	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcagcatatttcagaggttCcattagtttctcatccatct							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:77588010delC	uc001dhk.2	-	10	1066	c.1021delG	c.(1021-1023)GAAfs	p.E341fs	PIGK_uc010orj.1_Frame_Shift_Del_p.E265fs|PIGK_uc009wbx.2_Frame_Shift_Del_p.E247fs	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	341	Lumenal (Potential).			Missing: Loss of activity.	attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TTCAGAGGTTCCATTAGTTTC	0.313																		21	99	---	---								-	77588010	C	-	77588010	7	5	46	1	0	1	0	1	0	0	0	0	11890	864	30	0	174	0	PIGK	1	77588010	Frame_Shift_Del	DEL	C	TCGA-DK-A1AC-01A-11D-A13W-08	6075209	77588010	171662611	99	11796										
ELTD1	64123	broad.mit.edu	37	chr1	79385973	79385973	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggtgctttgaatttcactGaagaaccagaaggtaaaaat	9	6	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:79385973G>A	uc001diq.3	-	10	1512	c.1356C>T	c.(1354-1356)TTC>TTT	p.F452F		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	452	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GAATTTCACTGAAGAACCAGA	0.323													0	0	0	0.003954	0	25	74										A	79385973	G	A	79385973	2	1	46	1	0	0	0	0	0	0	0	1	5084	1281	45	1		1	ELTD1	1	79385973	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1797963	79385973	169864648	100	11797										
LPHN2	23266	broad.mit.edu	37	chr1	82417698	82417698	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aactggctaaacataccaaaGggccagtgtttgctggggat	12	8	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:82417698G>C	uc001dit.3	+	9	1835	c.1654G>C	c.(1654-1656)GGG>CGG	p.G552R	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.G552R|LPHN2_uc001div.2_Missense_Mutation_p.G552R|LPHN2_uc009wcd.2_Missense_Mutation_p.G552R|LPHN2_uc001diw.2_Missense_Mutation_p.G123R	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	552	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACATACCAAAGGGCCAGTGTT	0.398													0	0	0	0.00632	0	30	40										C	82417698	G	C	82417698	3	2	46	1	0	0	0	0	1	0	0	0	8916	1000	35	4	1680	4	LPHN2	1	82417698	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3031725	82417698	166832923	101	11798										
CLCA4	22802	broad.mit.edu	37	chr1	87029391	87029391	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctccggtggggagtgtttGatgagtacaatgaagatcag	14	6	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:87029391G>C	uc009wcs.2	+	4	540	c.496G>C	c.(496-498)GAT>CAT	p.D166H	CLCA4_uc009wct.2_Intron|CLCA4_uc009wcu.2_Intron	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	166						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GGGAGTGTTTGATGAGTACAA	0.408													0	0	0	0.006122	0	17	52										C	87029391	G	C	87029391	3	2	46	1	0	0	0	0	1	0	0	0	3459	1290	45	1	510	1	CLCA4	1	87029391	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4611693	87029391	162221230	102	11799										
GBP3	2635	broad.mit.edu	37	chr1	89477538	89477538	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggtccagcagctcctggagGgtttctgcgggcagctgcac	15	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:89477538G>A	uc001dmt.2	-	7	1246	c.1041C>T	c.(1039-1041)ACC>ACT	p.T347T	GBP3_uc010oss.1_Silent_p.T268T|GBP3_uc001dmu.2_Silent_p.T213T|GBP3_uc001dmv.2_Intron	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	347						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		GCTCCTGGAGGGTTTCTGCGG	0.537													0	0	0	0.000602	0	5	54										A	89477538	G	A	89477538	2	1	46	1	0	0	0	0	0	0	0	1	6275	1219	43	2		2	GBP3	1	89477538	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2448147	89477538	159773083	103	11800										
GFI1	2672	broad.mit.edu	37	chr1	92941706	92941706	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtttgcggctgtgggtgatGaggttggagctctggctgaa	18	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:92941706G>A	uc001dou.3	-	7	1313	c.1149C>T	c.(1147-1149)CTC>CTT	p.L383L	GFI1_uc001dov.3_Silent_p.L383L|GFI1_uc001dow.3_Silent_p.L383L	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	383	C2H2-type 5.				negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		TGTGGGTGATGAGGTTGGAGC	0.597													0	0	0	0.00308	0	6	10										A	92941706	G	A	92941706	2	1	46	1	0	0	0	0	0	0	0	1	6339	1277	45	1		1	GFI1	1	92941706	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3464168	92941706	156308915	104	11801										
EVI5	7813	broad.mit.edu	37	chr1	93170239	93170239	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaactcgacacaagagaaGagccactgtttcttcttgac	8	10	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:93170239G>A	uc001dox.2	-	3	354	c.344C>T	c.(343-345)TCT>TTT	p.S115F	EVI5_uc010otf.1_Missense_Mutation_p.S115F	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	115	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CACAAGAGAAGAGCCACTGTT	0.363													0	0	0	0.010818	0	33	96										A	93170239	G	A	93170239	3	1	46	1	0	0	0	0	1	0	0	0	5289	942	33	1	2152	1	EVI5	1	93170239	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	228533	93170239	156080382	105	11802										
BCAR3	8412	broad.mit.edu	37	chr1	94033313	94033313	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcacctctgccttcatgcagGagtttgctgaagggcttcag	11	11	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:94033313G>A	uc001dpz.2	-	10	2345	c.2070C>T	c.(2068-2070)CTC>CTT	p.L690L	BCAR3_uc001dqa.2_Silent_p.L690L|BCAR3_uc001dqb.2_Silent_p.L690L|BCAR3_uc001dpx.3_Silent_p.L366L|BCAR3_uc001dpy.2_Silent_p.L599L	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	690	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTTCATGCAGGAGTTTGCTGA	0.547													0	0	0	0.00333	0	26	62										A	94033313	G	A	94033313	2	1	46	1	0	0	0	0	0	0	0	1	1349	1161	41	1		1	BCAR3	1	94033313	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	863074	94033313	155217308	106	11803										
BCAR3	8412	broad.mit.edu	37	chr1	94048275	94048275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtagttggcctctgagttGagccaggcagagggagacga	16	8	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:94048275G>A	uc001dpz.2	-	7	1544	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	BCAR3_uc001dqa.2_Silent_p.L423L|BCAR3_uc001dqb.2_Silent_p.L423L|BCAR3_uc001dpx.3_Silent_p.L99L|BCAR3_uc001dpy.2_Silent_p.L332L|BCAR3_uc009wdm.1_Silent_p.L99L	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	423					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CCTCTGAGTTGAGCCAGGCAG	0.607													0	0	0	0.008871	0	20	47										A	94048275	G	A	94048275	2	1	46	1	0	0	0	0	0	0	0	1	1349	1277	45	1		1	BCAR3	1	94048275	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14962	94048275	155202346	107	11804										
GCLM	2730	broad.mit.edu	37	chr1	94370097	94370097	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accctgaccaaatctgggttGatttgggaactccattcatt	8	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:94370097G>A	uc001dqg.1	-	2	467	c.174C>T	c.(172-174)ATC>ATT	p.I58I		NM_002061	NP_002052	P48507	GSH0_HUMAN	glutamate-cysteine ligase regulatory protein	58					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	AATCTGGGTTGATTTGGGAAC	0.338													0	0	0	0.007413	0	16	79										A	94370097	G	A	94370097	2	1	46	1	0	0	0	0	0	0	0	1	6296	1280	45	1		1	GCLM	1	94370097	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	321822	94370097	154880524	108	11805										
SNX7	51375	broad.mit.edu	37	chr1	99157196	99157196	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatttttgaaccgaattgctGatcatccaactttaacattt	4	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:99157196G>A	uc010ouc.1	+	4	632	c.580G>A	c.(580-582)GAT>AAT	p.D194N	SNX7_uc001dsa.2_Missense_Mutation_p.D130N|SNX7_uc010oud.1_Intron	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	130	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		CCGAATTGCTGATCATCCAAC	0.338													0	0	0	0.013537	0	11	52										A	99157196	G	A	99157196	3	1	46	1	0	0	0	0	1	0	0	0	14907	1290	45	1	594	1	SNX7	1	99157196	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4787099	99157196	150093425	109	11806										
AGL	178	broad.mit.edu	37	chr1	100327239	100327239	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taaacttaatctgcaacaatCtggttcatttcagtattatt	4	7	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:100327239C>A	uc001dsi.1	+	3	663	c.263C>A	c.(262-264)TCT>TAT	p.S88Y	AGL_uc001dsj.1_Missense_Mutation_p.S88Y|AGL_uc001dsk.1_Missense_Mutation_p.S88Y|AGL_uc001dsl.1_Missense_Mutation_p.S88Y|AGL_uc001dsm.1_Missense_Mutation_p.S72Y|AGL_uc001dsn.1_Missense_Mutation_p.S71Y	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	88	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CTGCAACAATCTGGTTCATTT	0.313													1	0	5.35356e-11	0.00278	5.5852e-11	23	101										A	100327239	C	A	100327239	3	1	46	1	0	0	0	0	1	0	0	0	384	913	32	3	338	3	AGL	1	100327239	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1170043	100327239	148923382	110	11807										
PRMT6	55170	broad.mit.edu	37	chr1	107600219	107600219	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgccatctggttccaggtGaccttccctggaggggagtc	13	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:107600219G>A	uc010ous.1	+	1	953	c.882G>A	c.(880-882)GTG>GTA	p.V294V		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	294					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		GGTTCCAGGTGACCTTCCCTG	0.652													0	0	0	0.008871	0	20	10										A	107600219	G	A	107600219	2	1	46	1	0	0	0	0	0	0	0	1	12540	1277	45	1		1	PRMT6	1	107600219	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7272980	107600219	141650402	111	11808										
FAM102B	284611	broad.mit.edu	37	chr1	109171130	109171130	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtattctagagccatgtgatGaaattgagcagaaaatcgct	10	6	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:109171130G>A	uc010ouy.1	+	8	846	c.766G>A	c.(766-768)GAA>AAA	p.E256K		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	256										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GCCATGTGATGAAATTGAGCA	0.408													0	0	0	0.010818	0	30	83										A	109171130	G	A	109171130	3	1	46	1	0	0	0	0	1	0	0	0	5383	1291	45	1	796	1	FAM102B	1	109171130	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1570911	109171130	140079491	112	11809										
SARS	6301	broad.mit.edu	37	chr1	109756738	109756738	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctggtgaaggcagacagcGagtggcgacgatgtaagtac	16	7	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:109756738G>C	uc001dwu.1	+	1	199	c.124G>C	c.(124-126)GAG>CAG	p.E42Q	SARS_uc001dwt.1_Missense_Mutation_p.E42Q|SARS_uc001dwv.1_Missense_Mutation_p.E42Q|SARS_uc001dww.1_5'UTR|SARS_uc001dwx.1_Missense_Mutation_p.E42Q|SARS_uc009wfa.1_Missense_Mutation_p.E42Q|SARS_uc001dwy.1_5'UTR	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	42					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	GGCAGACAGCGAGTGGCGACG	0.587													0	0	0	0.00308	0	6	21										C	109756738	G	C	109756738	3	2	46	1	0	0	0	0	1	0	0	0	13844	1059	37	1	126	1	SARS	1	109756738	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	585608	109756738	139493883	113	11810										
GNAI3	2773	broad.mit.edu	37	chr1	110129467	110129467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctttttgaggaaaaaataaaGaggagtccgttaactatctg	9	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:110129467G>C	uc001dxz.2	+	7	994	c.837G>C	c.(835-837)AAG>AAC	p.K279N		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	279					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		AAAAAATAAAGAGGAGTCCGT	0.348													0	0	0	0.004656	0	28	69										C	110129467	G	C	110129467	3	2	46	1	0	0	0	0	1	0	0	0	6506	933	33	1	863	1	GNAI3	1	110129467	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	372729	110129467	139121154	114	11811										
GSTM2	2946	broad.mit.edu	37	chr1	110213924	110213924	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcaggagaaactgaaaccaGaatacctgcaggcactccct	8	13	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:110213924G>A	uc001dyi.2	+	6	690	c.376G>A	c.(376-378)GAA>AAA	p.E126K	GSTM2_uc001dyj.2_Missense_Mutation_p.E126K|GSTM2_uc010ovt.1_Missense_Mutation_p.E126K|GSTM2_uc009wfk.2_RNA	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1	126	GST C-terminal.				glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	ACTGAAACCAGAATACCTGCA	0.542													0	0	0	0.010818	0	33	33										A	110213924	G	A	110213924	3	1	46	1	0	0	0	0	1	0	0	0	6838	943	33	1	398	1	GSTM2	1	110213924	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	84457	110213924	139036697	115	11812										
KCNC4	3749	broad.mit.edu	37	chr1	110766114	110766114	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaccatgatctactacgctGagcgcattggggccaggccc	11	15	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:110766114G>A	uc001dzh.2	+	2	1264	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	KCNC4_uc001dzf.2_Missense_Mutation_p.E403K|KCNC4_uc009wfr.2_Missense_Mutation_p.E403K|KCNC4_uc001dzg.2_Missense_Mutation_p.E403K|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	403					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTACTACGCTGAGCGCATTGG	0.592													0	0	0	0.00278	0	24	88										A	110766114	G	A	110766114	3	1	46	1	0	0	0	0	1	0	0	0	8017	1291	45	1	1213	1	KCNC4	1	110766114	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	552190	110766114	138484507	116	11813										
DDX20	11218	broad.mit.edu	37	chr1	112299299	112299299	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagctaaatctggcaccggGaaaacctgtgtgttctccac	9	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:112299299G>A	uc001ebs.2	+	2	690	c.333G>A	c.(331-333)GGG>GGA	p.G111G	C1orf183_uc001ebp.1_5'Flank|uc001ebr.2_5'Flank|DDX20_uc010owf.1_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	111	Helicase ATP-binding.|ATP.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGCACCGGGAAAACCTGTG	0.428													0	0	0	0.010504	0	21	75										A	112299299	G	A	112299299	2	1	46	1	0	0	0	0	0	0	0	1	4348	1161	41	1		1	DDX20	1	112299299	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1533185	112299299	136951322	117	11814										
PHTF1	10745	broad.mit.edu	37	chr1	114242367	114242367	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctttaatacattgtttactaGagtaagctgttctttcttat	5	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:114242367G>C	uc009wgp.1	-	16	2553	c.2101C>G	c.(2101-2103)CTA>GTA	p.L701V	PHTF1_uc001edm.2_Missense_Mutation_p.L458V	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	701	Basic motif.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGTTTACTAGAGTAAGCTGT	0.284													0	0	0	0.009096	0	4	14										C	114242367	G	C	114242367	3	2	46	1	0	0	0	0	1	0	0	0	11862	933	33	1	199	1	PHTF1	1	114242367	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1943068	114242367	135008254	118	11815										
AP4B1	10717	broad.mit.edu	37	chr1	114447326	114447326	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttcaccacgtcctcggagCcaaggtacggcatcttccta	8	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:114447326C>T	uc001eeb.2	-	1	157	c.14G>A	c.(13-15)GGC>GAC	p.G5D	AP4B1_uc001eec.2_Missense_Mutation_p.G5D|AP4B1_uc001eed.2_Missense_Mutation_p.G5D|AP4B1_uc010owp.1_5'UTR|AP4B1_uc010owq.1_Missense_Mutation_p.G5D|DCLRE1B_uc001eeg.2_5'Flank|DCLRE1B_uc001eeh.2_5'Flank|DCLRE1B_uc001eei.2_5'Flank	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	5					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCCTCGGAGCCAAGGTACGG	0.562													0	0	0	0.01441	0	87	75										T	114447326	C	T	114447326	3	4	46	1	0	0	0	0	1	0	0	0	751	739	26	2	2245	2	AP4B1	1	114447326	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	204959	114447326	134803295	119	11816										
CASQ2	845	broad.mit.edu	37	chr1	116245548	116245548	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggggatactcacatctgtGacattcaccaccccaatctg	7	14	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:116245548G>A	uc001efx.3	-	10	1272	c.1008C>T	c.(1006-1008)GTC>GTT	p.V336V	CASQ2_uc010owu.1_Silent_p.V265V	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	336					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCACATCTGTGACATTCACCA	0.483													0	0	0	0.004482	0	9	15										A	116245548	G	A	116245548	2	1	46	1	0	0	0	0	0	0	0	1	2681	1277	45	1		1	CASQ2	1	116245548	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1798222	116245548	133005073	120	11817										
MAN1A2	10905	broad.mit.edu	37	chr1	117910898	117910898	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacatcacagggctaccttGagactttctgagaagtttat	8	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:117910898G>C	uc001ehd.1	+	1	814	c.93G>C	c.(91-93)TTG>TTC	p.L31F	MAN1A2_uc009whg.1_5'UTR	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	31	Cytoplasmic (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		GGGCTACCTTGAGACTTTCTG	0.493													0	0	0	0.00632	0	29	90										C	117910898	G	C	117910898	3	2	46	1	0	0	0	0	1	0	0	0	9211	1281	45	1	95	1	MAN1A2	1	117910898	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1665350	117910898	131339723	121	11818										
SPAG17	200162	broad.mit.edu	37	chr1	118624072	118624072	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcttgagtattcattttCatgacatattgctgccttat	6	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:118624072C>T	uc001ehk.2	-	14	2024	c.1956G>A	c.(1954-1956)ATG>ATA	p.M652I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	652						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TATTCATTTTCATGACATATT	0.408													0	0	0	0.012213	0	32	107										T	118624072	C	T	118624072	3	4	46	1	0	0	0	0	1	0	0	0	14979	826	29	1	4855	1	SPAG17	1	118624072	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	713174	118624072	130626549	122	11819										
PDE4DIP	9659	broad.mit.edu	37	chr1	144952287	144952287	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtttttggtgactcccttCagtttctctgagagctccag	9	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:144952287C>T	uc001elw.3	-	4	723	c.432G>A	c.(430-432)CTG>CTA	p.L144L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L210L|PDE4DIP_uc001emc.1_Silent_p.L144L|PDE4DIP_uc001emd.1_Silent_p.L144L|PDE4DIP_uc001emg.1_Silent_p.L144L|PDE4DIP_uc001emh.2_Silent_p.L281L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	144					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGACTCCCTTCAGTTTCTCTG	0.542			T	PDGFRB	MPD								0	0	0	0.010504	0	8	101										T	144952287	C	T	144952287	2	4	46	1	0	0	0	0	0	0	0	1	11643	813	29	1		1	PDE4DIP	1	144952287	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	26328215	144952287	104298334	123	11820										
PDE4DIP	9659	broad.mit.edu	37	chr1	145075044	145075044	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catggcctccatccagccatCaggcagggctccagctctgc	10	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145075044C>T	uc001emk.2	-	2	467	c.250G>A	c.(250-252)GAT>AAT	p.D84N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001emh.2_Intron			Q5VU43	MYOME_HUMAN	SubName: Full=Phosphodiesterase 4D interacting protein;	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATCCAGCCATCAGGCAGGGCT	0.502			T	PDGFRB	MPD								0	0	0	0.006214	0	8	57										T	145075044	C	T	145075044	3	4	46	1	0	0	0	0	1	0	0	0	11643	841	29	1		1	PDE4DIP	1	145075044	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	122757	145075044	104175577	124	11821										
NBPF10	100132406	broad.mit.edu	37	chr1	145293493	145293493	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cattgcgcccccagctggcaGagaagaaacagcagttcaga	11	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145293493G>A	uc001end.3	+	1	123	c.88G>A	c.(88-90)GAG>AAG	p.E30K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E30K|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Missense_Mutation_p.E30K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	30											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CCAGCTGGCAGAGAAGAAACA	0.483													0	0	0	0.01441	0	40	685										A	145293493	G	A	145293493	3	1	46	1	0	0	0	0	1	0	0	0	10193	943	33	1	90	1	NBPF10	1	145293493	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	218449	145293493	103957128	125	11822										
ANKRD35	148741	broad.mit.edu	37	chr1	145562892	145562892	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggctctgttggaaaagtaTaatacggcctgccgggaagt	13	7	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145562892T>G	uc001eob.1	+	10	2688	c.2580T>G	c.(2578-2580)TAT>TAG	p.Y860*	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Nonsense_Mutation_p.Y703*	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	860	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGAAAAGTATAATACGGCCT	0.677													0	0	0	0.013537	0	10	2										G	145562892	T	G	145562892	4	3	46	1	0	0	0	0	0	1	0	0	664	1413	49	5	2618	5	ANKRD35	1	145562892	Nonsense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	269399	145562892	103687729	126	11823										
RNF115	27246	broad.mit.edu	37	chr1	145688151	145688151	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gactctactcggcaaagccaGagcactgaggcctctgcaag	11	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145688151G>A	uc001eoj.2	+	9	1050	c.846G>A	c.(844-846)CAG>CAA	p.Q282Q	NBPF10_uc001emp.3_Intron|RNF115_uc001eok.2_Silent_p.Q249Q|RNF115_uc009wiy.2_Silent_p.Q201Q	NM_014455	NP_055270	Q9Y4L5	RN115_HUMAN	Rabring 7	282					protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						GGCAAAGCCAGAGCACTGAGG	0.458													0	0	0	0.01441	0	49	114										A	145688151	G	A	145688151	2	1	46	1	0	0	0	0	0	0	0	1	13430	933	33	1		1	RNF115	1	145688151	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	125259	145688151	103562470	127	11824										
GPR89B	51463	broad.mit.edu	37	chr1	147408770	147408770	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttggatttgggtggcttttCttcatgcgccaattgtttaa	10	6	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:147408770C>G	uc001epv.3	+	2	216	c.72C>G	c.(70-72)TTC>TTG	p.F24L	GPR89B_uc010ozs.1_Missense_Mutation_p.F24L|GPR89B_uc010ozt.1_5'UTR|GPR89B_uc010ozu.1_5'UTR|GPR89B_uc001epw.3_5'UTR|GPR89B_uc010ozv.1_5'UTR	NM_016334	NP_057418	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89B	24	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(923;0.0276)					GGTGGCTTTTCTTCATGCGCC	0.294													0	0	0	0.005524	0	32	176										G	147408770	C	G	147408770	3	3	46	1	0	0	0	0	1	0	0	0	6719	912	32	1	78	1	GPR89B	1	147408770	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1720619	147408770	101841851	128	11825										
HIST2H3D	653604	broad.mit.edu	37	chr1	149785205	149785205	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcggggccttgccgccggtcGacttgcgggcagtctgctta	15	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:149785205G>A	uc010pbl.1	-	1	32	c.32C>T	c.(31-33)TCG>TTG	p.S11L	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	11					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						GCCGCCGGTCGACTTGCGGGC	0.622													0	0	0	0.012319	0	13	28										A	149785205	G	A	149785205	3	1	46	1	0	0	0	0	1	0	0	0	7181	1059	37	1	380	1	HIST2H3D	1	149785205	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2376435	149785205	99465416	129	11826										
ANP32E	81611	broad.mit.edu	37	chr1	150193049	150193049	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtttcctcttctcccctcGaagacctccttcttcttaaa	3	16	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150193049G>A	uc001etw.2	-	7	1121	c.751C>T	c.(751-753)CGA>TGA	p.R251*	ANP32E_uc010pbt.1_RNA|ANP32E_uc010pbu.1_Nonsense_Mutation_p.R203*|ANP32E_uc010pbv.1_Nonsense_Mutation_p.R210*|ANP32E_uc001etv.3_Nonsense_Mutation_p.R250*	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	251	Asp/Glu-rich (highly acidic).					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTCCCCTCGAAGACCTCCT	0.368													0	0	0	0.01441	0	316	154										A	150193049	G	A	150193049	4	1	46	1	0	0	0	0	0	1	0	0	709	1066	37	1	59	1	ANP32E	1	150193049	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	407844	150193049	99057572	130	11827										
ADAMTSL4	54507	broad.mit.edu	37	chr1	150532646	150532646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcttgcgcacatgtcctgGagcggtctccccaggatccc	11	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150532646G>A	uc001eux.2	+	19	3435	c.3199G>A	c.(3199-3201)GAG>AAG	p.E1067K	ADAMTSL4_uc009wlw.2_Missense_Mutation_p.E1090K|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.E1028K|ADAMTSL4_uc009wlx.2_Missense_Mutation_p.E230K	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	1067					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			ACATGTCCTGGAGCGGTCTCC	0.627											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	83	24										A	150532646	G	A	150532646	3	1	46	1	0	0	0	0	1	0	0	0	277	1175	41	1	3340	1	ADAMTSL4	1	150532646	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	339597	150532646	98717975	131	11828										
MCL1	4170	broad.mit.edu	37	chr1	150550774	150550774	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtccttacgagaacgtctgtGatactttctgctaatggttc	9	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150550774G>A	uc001euz.2	-	2	1012	c.882C>T	c.(880-882)ATC>ATT	p.I294I	MCL1_uc010pch.1_Silent_p.I184I|MCL1_uc001eva.2_Intron	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	294					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GAACGTCTGTGATACTTTCTG	0.453													0	0	0	0.00874	0	34	266										A	150550774	G	A	150550774	2	1	46	1	0	0	0	0	0	0	0	1	9384	1280	45	1		1	MCL1	1	150550774	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	18128	150550774	98699847	132	11829										
PRUNE	58497	broad.mit.edu	37	chr1	150981133	150981133	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggactacctgcagggttgtCgagctgctctgcaggtaacg	14	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150981133C>G	uc001ewh.1	+	1	161	c.25C>G	c.(25-27)CGA>GGA	p.R9G	PRUNE_uc001ewi.1_5'UTR|PRUNE_uc010pco.1_5'UTR|PRUNE_uc001ewj.1_5'UTR|FAM63A_uc001ewc.2_5'Flank|FAM63A_uc010pcm.1_5'Flank|FAM63A_uc001ewd.2_5'Flank|FAM63A_uc001ewe.2_5'Flank|FAM63A_uc001ewf.2_5'Flank|FAM63A_uc010pcn.1_5'Flank|FAM63A_uc001ewg.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	9						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCAGGGTTGTCGAGCTGCTCT	0.602													0	0	0	0.004878	0	35	203										G	150981133	C	G	150981133	3	3	46	1	0	0	0	0	1	0	0	0	12640	876	31	1	27	1	PRUNE	1	150981133	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	430359	150981133	98269488	133	11830										
C1orf56	54964	broad.mit.edu	37	chr1	151021023	151021023	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acggcctttccgggcgccttCgagttggggcgctgagccag	16	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151021023C>T	uc001ewn.2	+	1	765	c.700C>T	c.(700-702)CGA>TGA	p.R234*		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	234						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGGGCGCCTTCGAGTTGGGGC	0.657											OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	206	86										T	151021023	C	T	151021023	4	4	46	1	0	0	0	0	0	1	0	0	2048	876	31	1	702	1	C1orf56	1	151021023	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	39890	151021023	98229598	134	11831										
PI4KB	5298	broad.mit.edu	37	chr1	151288752	151288752	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccagtggggtgcctctgctaGagactgccacgcctccatgc	12	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151288752G>A	uc001ext.2	-	2	621	c.206C>T	c.(205-207)TCT>TTT	p.S69F	PI4KB_uc001exr.2_Missense_Mutation_p.S81F|PI4KB_uc001exs.2_Missense_Mutation_p.S69F|PI4KB_uc001exu.2_Missense_Mutation_p.S69F|PI4KB_uc010pcw.1_Intron|PI4KB_uc009wmq.1_Missense_Mutation_p.S81F	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	69					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCCTCTGCTAGAGACTGCCAC	0.572													0	0	0	0.004007	0	15	137										A	151288752	G	A	151288752	3	1	46	1	0	0	0	0	1	0	0	0	11874	942	33	1	2288	1	PI4KB	1	151288752	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	267729	151288752	97961869	135	11832										
SELENBP1	8991	broad.mit.edu	37	chr1	151339220	151339220	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctccacatcagcggggttGaagccatctcgtaagacatt	10	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151339220G>A	uc001exx.2	-	6	689	c.642C>T	c.(640-642)TTC>TTT	p.F214F	SELENBP1_uc010pcy.1_Silent_p.F256F|SELENBP1_uc001exy.2_Silent_p.F111F|SELENBP1_uc001exz.2_Silent_p.F111F|SELENBP1_uc010pcz.1_Silent_p.F152F|SELENBP1_uc009wms.2_Intron|SELENBP1_uc009wmt.2_Silent_p.F111F|SELENBP1_uc001eya.2_Silent_p.F150F|SELENBP1_uc009wmu.2_Silent_p.F111F	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	214					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCGGGGTTGAAGCCATCTC	0.582													0	0	0	0.01441	0	51	225										A	151339220	G	A	151339220	2	1	46	1	0	0	0	0	0	0	0	1	14014	1281	45	1		1	SELENBP1	1	151339220	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	50468	151339220	97911401	136	11833										
PSMB4	5692	broad.mit.edu	37	chr1	151372617	151372617	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccatgctgggtgcctctggcGactacgctgatttccagtat	11	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151372617G>A	uc001eyc.1	+	2	324	c.301G>A	c.(301-303)GAC>AAC	p.D101N	PSMB4_uc010pda.1_Missense_Mutation_p.D101N|PSMB4_uc001eyb.1_Missense_Mutation_p.D101N	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	101					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCCTCTGGCGACTACGCTGA	0.537													0	0	0	0.01441	0	56	402										A	151372617	G	A	151372617	3	1	46	1	0	0	0	0	1	0	0	0	12679	1058	37	1	307	1	PSMB4	1	151372617	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	33397	151372617	97878004	137	11834										
TUFT1	7286	broad.mit.edu	37	chr1	151542174	151542174	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgttgagagcttgaggaaGacggtgcaggacttgctggc	17	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151542174G>C	uc001eyl.2	+	7	584	c.522G>C	c.(520-522)AAG>AAC	p.K174N	TUFT1_uc001eym.2_Missense_Mutation_p.K149N|TUFT1_uc010pdf.1_Missense_Mutation_p.K193N|TUFT1_uc010pdg.1_Missense_Mutation_p.K122N	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	174	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCTTGAGGAAGACGGTGCAGG	0.512													0	0	0	0.01441	0	62	405										C	151542174	G	C	151542174	3	2	46	1	0	0	0	0	1	0	0	0	16769	933	33	1	548	1	TUFT1	1	151542174	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	169557	151542174	97708447	138	11835										
RORC	6097	broad.mit.edu	37	chr1	151785508	151785508	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggagtgggagaagtcaaaGatggagctgatgagctcgct	17	5	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151785508G>T	uc001ezh.2	-	9	1308	c.1200C>A	c.(1198-1200)ATC>ATA	p.I400I	RORC_uc001ezg.2_Silent_p.I379I|RORC_uc010pdo.1_Silent_p.I454I|RORC_uc010pdp.1_Silent_p.I388I	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	400	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGAAGTCAAAGATGGAGCTGA	0.537													1	0	1.49723e-40	0.01441	1.59186e-40	72	26										T	151785508	G	T	151785508	2	4	46	1	0	0	0	0	0	0	0	1	13530	932	33	3		3	RORC	1	151785508	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	243334	151785508	97465113	139	11836										
TCHH	7062	broad.mit.edu	37	chr1	152083964	152083964	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcctcgcgcttcagcagctGatcgcgcctctcctcctgct	8	19	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:152083964G>A	uc001ezp.2	-	2	1729	c.1729C>T	c.(1729-1731)CAG>TAG	p.Q577*	TCHH_uc009wne.1_Nonsense_Mutation_p.Q577*	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	577	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCAGCAGCTGATCGCGCCTC	0.672													0	0	0	0.003271	0	28	56										A	152083964	G	A	152083964	4	1	46	1	0	0	0	0	0	1	0	0	15697	1299	45	1	4106	1	TCHH	1	152083964	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	298456	152083964	97166657	140	11837										
FLG	2312	broad.mit.edu	37	chr1	152276091	152276091	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaccccgggtgtccacgaatGgtgtcctgaccctcttggga	13	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:152276091G>A	uc001ezu.1	-	3	11307	c.11271C>T	c.(11269-11271)ACC>ACT	p.T3757T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3757	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCACGAATGGTGTCCTGAC	0.607									Ichthyosis				0	0	0	0.01441	0	559	215										A	152276091	G	A	152276091	2	1	46	1	0	0	0	0	0	0	0	1	5922	1335	47	2		2	FLG	1	152276091	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	192127	152276091	96974530	141	11838										
S100A6	6277	broad.mit.edu	37	chr1	153507246	153507246	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atactcctggaagttcacctCctggtccttgttccggtcca	8	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:153507246C>T	uc001fbw.1	-	3	513	c.199G>A	c.(199-201)GAG>AAG	p.E67K		NM_014624	NP_055439	P06703	S10A6_HUMAN	S100 calcium-binding protein A6	67	EF-hand 2.|2.				axonogenesis|positive regulation of fibroblast proliferation|signal transduction	cytosol|extrinsic to internal side of plasma membrane|nuclear envelope|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding|tropomyosin binding			ovary(1)	1	all_lung(78;1.66e-32)|Lung NSC(65;5.71e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAGTTCACCTCCTGGTCCTTG	0.478													0	0	0	0.01441	0	112	95										T	153507246	C	T	153507246	3	4	46	1	0	0	0	0	1	0	0	0	13782	864	30	1	77	1	S100A6	1	153507246	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1231155	153507246	95743375	142	11839										
ZBTB7B	51043	broad.mit.edu	37	chr1	154988999	154988999	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcccccgctggcctcgacctCtccaatggccacctggacac	8	20	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:154988999C>T	uc001fgk.3	+	4	1616	c.1458C>T	c.(1456-1458)CTC>CTT	p.L486L	ZBTB7B_uc009wpa.2_Silent_p.L486L|ZBTB7B_uc001fgj.3_Silent_p.L520L|ZBTB7B_uc010peq.1_Silent_p.L520L|ZBTB7B_uc001fgl.3_Silent_p.L486L	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	486					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCTCGACCTCTCCAATGGCC	0.682													0	0	0	0.010729	0	8	42										T	154988999	C	T	154988999	2	4	46	1	0	0	0	0	0	0	0	1	17551	900	32	1		1	ZBTB7B	1	154988999	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1481753	154988999	94261622	143	11840										
MUC1	4582	broad.mit.edu	37	chr1	155161824	155161824	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcccagggctggcctggtGactgggaccgaggtgacatc	17	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:155161824G>A	uc010pft.1	-	2	375	c.309C>T	c.(307-309)GTC>GTT	p.V103V	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_5'Flank|MUC1_uc001fhz.2_5'Flank|MUC1_uc010pfb.1_Intron|MUC1_uc010pfc.1_Intron|MUC1_uc009wph.2_Intron|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Intron|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Intron|MUC1_uc010pfi.1_Intron|MUC1_uc010pfj.1_Intron|MUC1_uc010pfk.1_Intron|MUC1_uc010pfl.1_Intron|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Intron|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Intron|MUC1_uc009wps.2_Intron|MUC1_uc009wpt.2_Intron|MUC1_uc001fic.2_Intron|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Intron|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Intron|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Intron|MUC1_uc001fiq.2_Intron|MUC1_uc009wpz.2_Intron|MUC1_uc010pfn.1_Intron|MUC1_uc009wqa.2_Intron|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Intron|MUC1_uc009wqc.2_Intron|MUC1_uc009wqd.2_Intron|MUC1_uc009wqb.2_Intron|MUC1_uc010pfq.1_Intron|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Intron|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Intron|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_Intron|MUC1_uc001fik.2_Intron|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Intron|MUC1_uc001fis.1_Intron|uc009wqh.2_5'Flank|MUC1_uc001fiv.1_Silent_p.V112V|MUC1_uc001fiw.1_Silent_p.V103V			P15941	MUC1_HUMAN	SubName: Full=MUC1 isoform M13;	103	Extracellular (Potential).|3.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGGCCTGGTGACTGGGACCG	0.697			T	IGH@	B-NHL								0	0	0	0.004482	0	9	50										A	155161824	G	A	155161824	2	1	46	1	0	0	0	0	0	0	0	1	9970	1305	45	1		1	MUC1	1	155161824	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	172825	155161824	94088797	144	11841										
GON4L	54856	broad.mit.edu	37	chr1	155823271	155823271	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaaggtagggtgattccctGagagatggccacatcaacac	13	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:155823271G>A	uc001flz.2	-	2	398	c.301C>T	c.(301-303)CAG>TAG	p.Q101*	GON4L_uc001fly.1_Nonsense_Mutation_p.Q101*|GON4L_uc009wrh.1_Nonsense_Mutation_p.Q101*|GON4L_uc001fma.1_Nonsense_Mutation_p.Q101*|GON4L_uc001fmc.2_Nonsense_Mutation_p.Q101*|GON4L_uc001fmd.3_Nonsense_Mutation_p.Q101*|GON4L_uc009wri.2_5'UTR	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	101					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTGATTCCCTGAGAGATGGCC	0.443													0	0	0	0.01441	0	49	362										A	155823271	G	A	155823271	4	1	46	1	0	0	0	0	0	1	0	0	6572	1299	45	1	6662	1	GON4L	1	155823271	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	661447	155823271	93427350	145	11842										
MEX3A	92312	broad.mit.edu	37	chr1	156051412	156051412	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggtgttgctgctgcccttCaggcgcagctcggcctcttt	13	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156051412C>T	uc001fnd.3	-	1	378	c.378G>A	c.(376-378)CTG>CTA	p.L126L	LMNA_uc001fnf.1_5'Flank	NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	126						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					TGCTGCCCTTCAGGCGCAGCT	0.522													0	0	0	0.008871	0	19	0										T	156051412	C	T	156051412	2	4	46	1	0	0	0	0	0	0	0	1	9509	813	29	1		1	MEX3A	1	156051412	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	228141	156051412	93199209	146	11843										
TMEM79	84283	broad.mit.edu	37	chr1	156256052	156256052	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtttcccaactccacccaggGatcctggtgtacgggctgag	12	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156256052G>A	uc010phi.1	+	3	955	c.759G>A	c.(757-759)GGG>GGA	p.G253G	TMEM79_uc001fod.2_Silent_p.G94G|TMEM79_uc009wrw.2_Silent_p.G253G	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	253	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					TCCACCCAGGGATCCTGGTGT	0.612													0	0	0	0.003954	0	26	105										A	156256052	G	A	156256052	2	1	46	1	0	0	0	0	0	0	0	1	16200	1188	41	1		1	TMEM79	1	156256052	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	204640	156256052	92994569	147	11844										
C1orf85	112770	broad.mit.edu	37	chr1	156263941	156263941	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccggggagaggctccaatCagggccacctctagctgaca	12	15	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156263941C>T	uc001foh.2	-	4	679	c.666G>A	c.(664-666)CTG>CTA	p.L222L	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Silent_p.L222L|C1orf85_uc009wrx.2_Silent_p.L155L|C1orf85_uc001foj.2_Silent_p.L136L	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	222	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					AGGCTCCAATCAGGGCCACCT	0.627													0	0	0	0.01441	0	101	41										T	156263941	C	T	156263941	2	4	46	1	0	0	0	0	0	0	0	1	2062	813	29	1		1	C1orf85	1	156263941	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7889	156263941	92986680	148	11845										
CCT3	7203	broad.mit.edu	37	chr1	156280783	156280783	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggtgctggccccacagttCtggatcagggtacgaggaat	14	9	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156280783C>T	uc001fol.1	-	12	1579	c.1359G>A	c.(1357-1359)CAG>CAA	p.Q453Q	CCT3_uc001fom.1_Silent_p.Q452Q|CCT3_uc001fon.1_Silent_p.Q415Q|CCT3_uc010phj.1_Silent_p.Q407Q|CCT3_uc010phk.1_Silent_p.Q407Q|CCT3_uc010phl.1_Silent_p.Q407Q	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	453					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCCCACAGTTCTGGATCAGGG	0.537													0	0	0	0.010729	0	11	116										T	156280783	C	T	156280783	2	4	46	1	0	0	0	0	0	0	0	1	2954	912	32	1		1	CCT3	1	156280783	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	16842	156280783	92969838	149	11846										
RHBG	57127	broad.mit.edu	37	chr1	156354598	156354598	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcatgaggataaagcccaGagacctctgagggtggagga	16	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156354598G>A	uc010pho.1	+	11	1376	c.1338G>A	c.(1336-1338)CAG>CAA	p.Q446Q	RHBG_uc001fos.2_3'UTR|RHBG_uc009wrz.2_3'UTR|RHBG_uc001for.2_3'UTR	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	Error:Variant_position_missing_in_Q9H310_after_alignment					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					ATAAAGCCCAGAGACCTCTGA	0.592											OREG0013871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	34	8										A	156354598	G	A	156354598	2	1	46	1	0	0	0	0	0	0	0	1	13324	933	33	1		1	RHBG	1	156354598	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	73815	156354598	92896023	150	11847										
FCRL4	83417	broad.mit.edu	37	chr1	157550118	157550118	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgaggtctcacctggtttCgtctcccaagaaaccaactc	7	14	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:157550118C>T	uc001fqw.2	-	8	1406	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	424	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CACCTGGTTTCGTCTCCCAAG	0.413													0	0	0	0.01441	0	202	80										T	157550118	C	T	157550118	3	4	46	1	0	0	0	0	1	0	0	0	5797	893	31	1	297	1	FCRL4	1	157550118	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1195520	157550118	91700503	151	11848										
CCDC19	25790	broad.mit.edu	37	chr1	159842861	159842861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacttccttctgctggttctCgcgcacctggcgccggagct	11	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:159842861C>T	uc001fui.2	-	11	1468	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.E399K|CCDC19_uc001ful.2_Missense_Mutation_p.E399K	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	484	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TGCTGGTTCTCGCGCACCTGG	0.602													0	0	0	0.008361	0	28	94										T	159842861	C	T	159842861	3	4	46	1	0	0	0	0	1	0	0	0	2795	893	31	1	213	1	CCDC19	1	159842861	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2292743	159842861	89407760	152	11849										
IGSF8	93185	broad.mit.edu	37	chr1	160063790	160063790	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caactggtgcctcgggcacaGatcgcccaaaggacactgcc	11	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160063790G>T	uc001fva.2	-	3	659	c.614C>A	c.(613-615)TCT>TAT	p.S205Y	IGSF8_uc001fuz.2_Missense_Mutation_p.S205Y|IGSF8_uc009wtf.2_Missense_Mutation_p.S205Y	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	205	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTCGGGCACAGATCGCCCAAA	0.627													1	0	4.45467e-35	0.011902	4.72927e-35	42	63										T	160063790	G	T	160063790	3	4	46	1	0	0	0	0	1	0	0	0	7604	942	33	3	1243	3	IGSF8	1	160063790	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	220929	160063790	89186831	153	11850										
CASQ1	844	broad.mit.edu	37	chr1	160162631	160162631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagacaagggtgttggcttcGggctggtagactctgagaag	16	6	1	3	rs143532190		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160162631G>A	uc010pja.1	+	2	576	c.319G>A	c.(319-321)GGG>AGG	p.G107R		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	107						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTTGGCTTCGGGCTGGTAGA	0.512											OREG0013927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	36	281										A	160162631	G	A	160162631	3	1	46	1	0	0	0	0	1	0	0	0	2680	1116	39	2	325	2	CASQ1	1	160162631	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	98841	160162631	89087990	154	11851										
CASQ1	844	broad.mit.edu	37	chr1	160163575	160163575	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatgtatgtattcaagggaGatgaagtcattgagtacgat	12	4	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160163575G>C	uc010pja.1	+	3	660	c.403G>C	c.(403-405)GAT>CAT	p.D135H		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	135						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATTCAAGGGAGATGAAGTCAT	0.532													0	0	0	0.010504	0	17	82										C	160163575	G	C	160163575	3	2	46	1	0	0	0	0	1	0	0	0	2680	942	33	1	413	1	CASQ1	1	160163575	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	944	160163575	89087046	155	11852										
COPA	1314	broad.mit.edu	37	chr1	160261692	160261692	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggacaaacccacaatgtactCacggcaaatggtgatgagct	10	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160261692C>T	uc009wti.2	-	30	3569	c.3175G>A	c.(3175-3177)GAG>AAG	p.E1059K	COPA_uc001fvv.3_Missense_Mutation_p.E1068K	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	1059					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACAATGTACTCACGGCAAATG	0.522											OREG0013929	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	367	115										T	160261692	C	T	160261692	3	4	46	1	0	0	0	0	1	0	0	0	3727	835	29	1	515	1	COPA	1	160261692	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	98117	160261692	88988929	156	11853										
CD48	962	broad.mit.edu	37	chr1	160681499	160681499	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctggtcaccaggagtgacaGaggcagcagtagcaattcca	13	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160681499G>A	uc001fwn.2	-	1	87	c.55C>T	c.(55-57)CTG>TTG	p.L19L	CD48_uc001fwo.1_Silent_p.L19L|CD48_uc001fwp.2_Silent_p.L19L	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	19					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AGGAGTGACAGAGGCAGCAGT	0.532													0	0	0	0.01441	0	52	14										A	160681499	G	A	160681499	2	1	46	1	0	0	0	0	0	0	0	1	3020	933	33	1		1	CD48	1	160681499	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	419807	160681499	88569122	157	11854										
MPZ	4359	broad.mit.edu	37	chr1	161277071	161277071	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatggcatctctgcccccttCgggctggtagcgccaggtga	13	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161277071C>T	uc001gaf.3	-	2	278	c.241G>A	c.(241-243)GAA>AAA	p.E81K	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	71	Ig-like V-type.|Extracellular (Potential).				synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			CTGCCCCCTTCGGGCTGGTAG	0.552													0	0	0	0.001168	0	4	67										T	161277071	C	T	161277071	3	4	46	1	0	0	0	0	1	0	0	0	9748	893	31	1	555	1	MPZ	1	161277071	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	595572	161277071	87973550	158	11855										
FCGR2B	2213	broad.mit.edu	37	chr1	161641245	161641245	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caacgtgctccaggaggactCtgtgactctgacatgccggg	13	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161641245C>G	uc001gaz.1	+	3	289	c.197C>G	c.(196-198)TCT>TGT	p.S66C	FCGR2B_uc009wum.1_Missense_Mutation_p.S66C|FCGR2B_uc001gay.1_Missense_Mutation_p.S65C|FCGR2B_uc001gba.1_Missense_Mutation_p.S65C|FCGR2B_uc001gbb.1_Missense_Mutation_p.S66C|FCGR2B_uc009wun.1_Missense_Mutation_p.S59C	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	66	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAGGAGGACTCTGTGACTCTG	0.587			T	NaN	ALL								0	0	0	0.006122	0	18	99										G	161641245	C	G	161641245	3	3	46	1	0	0	0	0	1	0	0	0	5782	913	32	1	207	1	FCGR2B	1	161641245	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	364174	161641245	87609376	159	11856			1	46		3	3	164	C		4.285033e-05
FCGR2B	2213	broad.mit.edu	37	chr1	161641318	161641318	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggttccacaatgggaatctCattcccacccacacgcagcc	7	16	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161641318C>G	uc001gaz.1	+	3	362	c.270C>G	c.(268-270)CTC>CTG	p.L90L	FCGR2B_uc009wum.1_Silent_p.L90L|FCGR2B_uc001gay.1_Silent_p.L89L|FCGR2B_uc001gba.1_Silent_p.L89L|FCGR2B_uc001gbb.1_Silent_p.L90L|FCGR2B_uc009wun.1_Silent_p.L83L	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	90	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATGGGAATCTCATTCCCACCC	0.587			T	NaN	ALL								0	0	0	0.00499	0	15	87										G	161641318	C	G	161641318	2	3	46	1	0	0	0	0	0	0	0	1	5782	813	29	1		1	FCGR2B	1	161641318	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	73	161641318	87609303	160	11857			1	46		3	3	164	C		4.285033e-05
FCGR2B	2213	broad.mit.edu	37	chr1	161641408	161641408	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagactggccagaccagcctCagcgaccctgtgcatctgac	10	16	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161641408C>T	uc001gaz.1	+	3	452	c.360C>T	c.(358-360)CTC>CTT	p.L120L	FCGR2B_uc009wum.1_Silent_p.L120L|FCGR2B_uc001gay.1_Silent_p.L119L|FCGR2B_uc001gba.1_Silent_p.L119L|FCGR2B_uc001gbb.1_Silent_p.L120L|FCGR2B_uc009wun.1_Silent_p.L113L	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	120	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGACCAGCCTCAGCGACCCTG	0.592			T	NaN	ALL								0	0	0	0.013537	0	11	54										T	161641408	C	T	161641408	2	4	46	1	0	0	0	0	0	0	0	1	5782	813	29	1		1	FCGR2B	1	161641408	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	90	161641408	87609213	161	11858			1	46		3	3	164	C		4.285033e-05
FCRLB	127943	broad.mit.edu	37	chr1	161695648	161695648	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgccctatgcgccagtgttCgagggtgagccgctagtcct	14	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161695648C>T	uc001gbh.2	+	6	579	c.345C>T	c.(343-345)TTC>TTT	p.F115F	FCRLB_uc009wus.2_Silent_p.F115F|FCRLB_uc001gbj.2_Silent_p.F115F|FCRLB_uc001gbk.2_Silent_p.F115F|FCRLB_uc001gbl.2_Silent_p.F108F|FCRLB_uc001gbm.2_Silent_p.F108F|FCRLB_uc001gbi.2_Silent_p.F115F|FCRLB_uc001gbn.3_5'Flank	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	115	Ig-like C2-type 2.					endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CGCCAGTGTTCGAGGGTGAGC	0.592													0	0	0	0.001984	0	4	52										T	161695648	C	T	161695648	2	4	46	1	0	0	0	0	0	0	0	1	5801	883	31	1		1	FCRLB	1	161695648	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	54240	161695648	87554973	162	11859										
FCRLB	127943	broad.mit.edu	37	chr1	161696695	161696695	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagtcccggagcccgaggtCgaggagctcgaatcgtactg	14	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161696695C>T	uc001gbh.2	+	7	1011	c.777C>T	c.(775-777)GTC>GTT	p.V259V	FCRLB_uc009wus.2_Silent_p.V259V|FCRLB_uc001gbj.2_Missense_Mutation_p.S211L|FCRLB_uc001gbk.2_Nonsense_Mutation_p.R225*|FCRLB_uc001gbl.2_Missense_Mutation_p.S204L|FCRLB_uc001gbm.2_Nonsense_Mutation_p.R218*|FCRLB_uc001gbi.2_Silent_p.V259V|FCRLB_uc001gbn.3_Nonsense_Mutation_p.R262*	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	259						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			AGCCCGAGGTCGAGGAGCTCG	0.687													0	0	0	0.004007	0	11	3										T	161696695	C	T	161696695	2	4	46	1	0	0	0	0	0	0	0	1	5801	871	31	1		1	FCRLB	1	161696695	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1047	161696695	87553926	163	11860										
BLZF1	8548	broad.mit.edu	37	chr1	169351514	169351514	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccagctgagaaaatggctGaaacggtaaaatattttctt	8	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:169351514G>T	uc001gfx.1	+	6	1449	c.1012G>T	c.(1012-1014)GAA>TAA	p.E338*	BLZF1_uc001gfy.2_Nonsense_Mutation_p.E338*|BLZF1_uc009wvp.1_Intron	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	338					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					GAAAATGGCTGAAACGGTAAA	0.279													1	0	4.3838e-07	0.001855	4.5106e-07	14	50										T	169351514	G	T	169351514	4	4	46	1	0	0	0	0	0	1	0	0	1453	1291	45	3	1030	3	BLZF1	1	169351514	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7654819	169351514	79899107	164	11861										
SELE	6401	broad.mit.edu	37	chr1	169696928	169696928	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgtccctgagatgtgcactCaagttgagttgatccatgta	10	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:169696928C>G	uc001ggm.3	-	9	1577	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	474	Extracellular (Potential).|Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GATGTGCACTCAAGTTGAGTT	0.448													0	0	0	0.01441	0	82	65										G	169696928	C	G	169696928	3	3	46	1	0	0	0	0	1	0	0	0	14013	835	29	1	432	1	SELE	1	169696928	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	345414	169696928	79553693	165	11862										
RC3H1	149041	broad.mit.edu	37	chr1	173916678	173916678	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtttctgctgctcttctctGaagatctaatcgctggtccc	9	12	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:173916678G>A	uc001gju.3	-	14	2653	c.2566C>T	c.(2566-2568)CAG>TAG	p.Q856*	RC3H1_uc010pms.1_Nonsense_Mutation_p.Q856*|RC3H1_uc001gjv.2_Nonsense_Mutation_p.Q856*|RC3H1_uc010pmt.1_Nonsense_Mutation_p.Q856*	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	856					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GCTCTTCTCTGAAGATCTAAT	0.438													0	0	0	0.010771	0	42	34										A	173916678	G	A	173916678	4	1	46	1	0	0	0	0	0	1	0	0	13166	1299	45	1	859	1	RC3H1	1	173916678	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4219750	173916678	75333943	166	11863										
RFWD2	64326	broad.mit.edu	37	chr1	176012859	176012859	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatttacctgatagacctttGacctctgtcctgtgaatcca	6	11	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:176012859G>A	uc001gku.1	-	13	1773	c.1517C>T	c.(1516-1518)TCA>TTA	p.S506L	RFWD2_uc001gkv.1_Missense_Mutation_p.S482L|RFWD2_uc001gkw.1_Missense_Mutation_p.S266L|RFWD2_uc009wwv.2_Missense_Mutation_p.S305L|RFWD2_uc001gkt.1_Missense_Mutation_p.S345L	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	506	WD 2.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						ATAGACCTTTGACCTCTGTCC	0.353													0	0	0	0.01441	0	75	246										A	176012859	G	A	176012859	3	1	46	1	0	0	0	0	1	0	0	0	13260	1294	45	1	710	1	RFWD2	1	176012859	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2096181	176012859	73237762	167	11864										
SOAT1	6646	broad.mit.edu	37	chr1	179320459	179320459	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctatttttagtggctttCaacttcattgtcaatgatag	6	7	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:179320459C>G	uc001gml.2	+	15	1521	c.1458C>G	c.(1456-1458)TTC>TTG	p.F486L	SOAT1_uc010pni.1_Missense_Mutation_p.F421L|SOAT1_uc001gmm.2_Missense_Mutation_p.F428L|SOAT1_uc010pnj.1_Missense_Mutation_p.F222L|SOAT1_uc010pnk.1_Missense_Mutation_p.F421L	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	486	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	TAGTGGCTTTCAACTTCATTG	0.269													0	0	0	0.01441	0	57	169										G	179320459	C	G	179320459	3	3	46	1	0	0	0	0	1	0	0	0	14910	825	29	1	1512	1	SOAT1	1	179320459	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3307600	179320459	69930162	168	11865										
C1orf125	126859	broad.mit.edu	37	chr1	179339182	179339182	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataaattcaaatacctgattGaccatcccgtctccctcaca	3	14	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:179339182G>A	uc001gmo.2	+	4	470	c.343G>A	c.(343-345)GAC>AAC	p.D115N	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_5'UTR|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.D115N	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	115											0						ATACCTGATTGACCATCCCGT	0.413													0	0	0	0.008291	0	9	31										A	179339182	G	A	179339182	3	1	46	1	0	0	0	0	1	0	0	0	1993	1290	45	1	353	1	C1orf125	1	179339182	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	18723	179339182	69911439	169	11866										
TDRD5	163589	broad.mit.edu	37	chr1	179609578	179609578	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcttgggtgagaccagtaGaggtatgtttgcttgtctcc	14	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:179609578G>C	uc001gnf.1	+	11	2048	c.1798G>C	c.(1798-1800)GAG>CAG	p.E600Q	TDRD5_uc010pnp.1_Missense_Mutation_p.E600Q|TDRD5_uc001gnh.1_Missense_Mutation_p.E155Q	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	600					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GAGACCAGTAGAGGTATGTTT	0.264													0	0	0	0.012319	0	19	89										C	179609578	G	C	179609578	3	2	46	1	0	0	0	0	1	0	0	0	15730	943	33	1	1836	1	TDRD5	1	179609578	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	270396	179609578	69641043	170	11867										
CEP350	9857	broad.mit.edu	37	chr1	180080149	180080149	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taggttcaggagctccatgaGgaggaggcacagtgggtgaa	17	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:180080149G>A	uc001gnt.2	+	38	9590	c.9207G>A	c.(9205-9207)GAG>GAA	p.E3069E	CEP350_uc009wxl.2_Silent_p.E3068E|CEP350_uc001gnv.2_Silent_p.E1204E|CEP350_uc001gnw.1_Silent_p.E826E|CEP350_uc001gnx.1_Silent_p.E826E	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	3069						centrosome|nucleus|spindle				ovary(4)	4						AGCTCCATGAGGAGGAGGCAC	0.413													0	0	0	0.007413	0	17	59										A	180080149	G	A	180080149	2	1	46	1	0	0	0	0	0	0	0	1	3254	991	35	2		2	CEP350	1	180080149	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	470571	180080149	69170472	171	11868										
RGS16	6004	broad.mit.edu	37	chr1	182571103	182571103	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatatgggggctctaacctCtttaggggcctcactgcaaa	11	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:182571103C>T	uc001gpl.3	-	4	539	c.385G>A	c.(385-387)GAG>AAG	p.E129K	RGS16_uc010pnv.1_Missense_Mutation_p.E129K	NM_002928	NP_002919	O15492	RGS16_HUMAN	regulator of G-protein signalling 16	129	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(1)	1						GCTCTAACCTCTTTAGGGGCC	0.567											OREG0014036	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	39	43										T	182571103	C	T	182571103	3	4	46	1	0	0	0	0	1	0	0	0	13298	922	32	1	231	1	RGS16	1	182571103	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2490954	182571103	66679518	172	11869										
DHX9	1660	broad.mit.edu	37	chr1	182845653	182845653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacagcgcaaagtgtttgatCcagtaccagttggagtaacc	10	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:182845653C>T	uc001gpr.2	+	18	2264	c.2101C>T	c.(2101-2103)CCA>TCA	p.P701S	DHX9_uc001gps.2_Missense_Mutation_p.P487S|DHX9_uc001gpt.2_5'Flank	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	701	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AGTGTTTGATCCAGTACCAGT	0.403													0	0	0	0.00632	0	28	38										T	182845653	C	T	182845653	3	4	46	1	0	0	0	0	1	0	0	0	4516	855	30	1	2167	1	DHX9	1	182845653	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	274550	182845653	66404968	173	11870										
C1orf26	54823	broad.mit.edu	37	chr1	185171807	185171807	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgatagaaacttaagaaaCaaaggcctaataagtggtgt	10	4	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:185171807C>G	uc001grg.3	+	11	1659	c.1545C>G	c.(1543-1545)AAC>AAG	p.N515K	C1orf26_uc001grh.3_Missense_Mutation_p.N515K	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	515	PINc.										0						ACTTAAGAAACAAAGGCCTAA	0.368													0	0	0	0.005443	0	28	56										G	185171807	C	G	185171807	3	3	46	1	0	0	0	0	1	0	0	0	2035	477	17	4	1583	4	C1orf26	1	185171807	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2326154	185171807	64078814	174	11871										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185276692	185276692	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgctcctgaatataagcatCaaccttattcaacaaacggg	6	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:185276692C>T	uc001grl.2	-	6	1083	c.460G>A	c.(460-462)GAT>AAT	p.D154N	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	154	BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ATATAAGCATCAACCTTATTC	0.368													0	0	0	0.010818	0	34	39										T	185276692	C	T	185276692	3	4	46	1	0	0	0	0	1	0	0	0	7930	826	29	1	1508	1	IVNS1ABP	1	185276692	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	104885	185276692	63973929	175	11872										
HMCN1	83872	broad.mit.edu	37	chr1	185703957	185703957	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtattcctgtttgctcttCtttattcttccctagctcaa	4	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:185703957C>G	uc001grq.1	+	1	275	c.46C>G	c.(46-48)CTT>GTT	p.L16V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	16					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTTTGCTCTTCTTTATTCTTC	0.488													0	0	0	0.01441	0	106	108										G	185703957	C	G	185703957	3	3	46	1	0	0	0	0	1	0	0	0	7220	913	32	1	48	1	HMCN1	1	185703957	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	427265	185703957	63546664	176	11873										
PLA2G4A	5321	broad.mit.edu	37	chr1	186946811	186946811	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgtttgatcgggaagggctGaaggagtgctatgtctttaa	15	4	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:186946811G>T	uc001gsc.2	+	16	2056	c.1851G>T	c.(1849-1851)CTG>CTT	p.L617L	PLA2G4A_uc010pos.1_Silent_p.L557L	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	617	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GGGAAGGGCTGAAGGAGTGCT	0.423													1	0	1.77063e-15	0.005443	1.86247e-15	27	81										T	186946811	G	T	186946811	2	4	46	1	0	0	0	0	0	0	0	1	12001	1277	45	3		3	PLA2G4A	1	186946811	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1242854	186946811	62303810	177	11874										
KCNT2	343450	broad.mit.edu	37	chr1	196342316	196342316	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtaataagtgtagatgttgCtgggcatatacagtttaaag	11	3	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:196342316C>T	uc001gtd.1	-	14	1417	c.1357G>A	c.(1357-1359)GCA>ACA	p.A453T	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.A453T|KCNT2_uc001gtf.1_Missense_Mutation_p.A453T|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.A453T|KCNT2_uc009wyv.1_Missense_Mutation_p.A428T	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	453	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GTAGATGTTGCTGGGCATATA	0.284													0	0	0	0.010818	0	31	103										T	196342316	C	T	196342316	3	4	46	1	0	0	0	0	1	0	0	0	8092	797	28	2	2110	2	KCNT2	1	196342316	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9395505	196342316	52908305	178	11875										
ZBTB41	360023	broad.mit.edu	37	chr1	197145778	197145778	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcactcatatcttttatcatCatgatgtactcgtaagtgaa	6	8	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:197145778C>T	uc001gtx.1	-	7	1864	c.1795G>A	c.(1795-1797)GAT>AAT	p.D599N	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CTTTTATCATCATGATGTACT	0.303													0	0	0	0.01441	0	59	71										T	197145778	C	T	197145778	3	4	46	1	0	0	0	0	1	0	0	0	17540	826	29	1	950	1	ZBTB41	1	197145778	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	803462	197145778	52104843	179	11876										
NEK7	140609	broad.mit.edu	37	chr1	198288556	198288556	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcacagctccgacagttagtTaatatgtgcatcaacccaga	7	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:198288556T>G	uc001gun.3	+	10	1140	c.813T>G	c.(811-813)GTT>GTG	p.V271V		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	271	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						GACAGTTAGTTAATATGTGCA	0.383													0	0	0	0.008291	0	11	35										G	198288556	T	G	198288556	2	3	46	1	0	0	0	0	0	0	0	1	10329	1741	61	5		5	NEK7	1	198288556	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1142778	198288556	50962065	180	11877										
ZNF281	23528	broad.mit.edu	37	chr1	200377338	200377338	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctatgccaagtgagccacttGgttttccagacaaggatttc	9	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:200377338G>A	uc001gve.2	-	2	1603	c.1496C>T	c.(1495-1497)CCA>CTA	p.P499L	ZNF281_uc001gvf.1_Missense_Mutation_p.P499L|ZNF281_uc001gvg.1_Missense_Mutation_p.P463L	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	499					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TGAGCCACTTGGTTTTCCAGA	0.368													0	0	0	0.004878	0	37	124										A	200377338	G	A	200377338	3	1	46	1	0	0	0	0	1	0	0	0	17815	1348	47	2	1195	2	ZNF281	1	200377338	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2088782	200377338	48873283	181	11878										
C1orf106	55765	broad.mit.edu	37	chr1	200878016	200878016	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctggaaggaaaccagcctgGaccacccctatgagaagccc	10	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:200878016G>A	uc001gvo.2	+	7	1018	c.988G>A	c.(988-990)GAC>AAC	p.D330N	C1orf106_uc010ppm.1_Missense_Mutation_p.D245N	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	330	Pro-rich.									skin(2)|ovary(1)	3						AACCAGCCTGGACCACCCCTA	0.642													0	0	0	0.010729	0	9	44										A	200878016	G	A	200878016	3	1	46	1	0	0	0	0	1	0	0	0	1980	1174	41	1	1014	1	C1orf106	1	200878016	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	500678	200878016	48372605	182	11879										
C1orf106	55765	broad.mit.edu	37	chr1	200880945	200880945	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcggtacgtggtggtggctGagagccccctgccgcctggc	18	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:200880945G>A	uc001gvo.2	+	9	1609	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	C1orf106_uc010ppm.1_Missense_Mutation_p.E442K	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	527										skin(2)|ovary(1)	3						GGTGGTGGCTGAGAGCCCCCT	0.731													0	0	0	0.001984	0	4	12										A	200880945	G	A	200880945	3	1	46	1	0	0	0	0	1	0	0	0	1980	1291	45	1	1613	1	C1orf106	1	200880945	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2929	200880945	48369676	183	11880										
PPP1R12B	4660	broad.mit.edu	37	chr1	202318026	202318026	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagcgggcagagtcggcgcGaatgcggcgggcagagcagc	20	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:202318026G>A	uc001gya.1	+	1	191	c.47G>A	c.(46-48)CGA>CAA	p.R16Q	PPP1R12B_uc001gxy.2_Missense_Mutation_p.R16Q|PPP1R12B_uc009xad.1_5'UTR|PPP1R12B_uc009xae.1_Missense_Mutation_p.R16Q|PPP1R12B_uc001gxz.1_Missense_Mutation_p.R16Q	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	16					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAGTCGGCGCGAATGCGGCGG	0.682													0	0	0	0.004672	0	3	6										A	202318026	G	A	202318026	3	1	46	1	0	0	0	0	1	0	0	0	12355	1058	37	1	49	1	PPP1R12B	1	202318026	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1437081	202318026	46932595	184	11881										
BTG2	7832	broad.mit.edu	37	chr1	203276346	203276346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagggtggccagccagatcgGactcagccagccccagctgc	13	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:203276346G>A	uc001gzq.2	+	2	328	c.257G>A	c.(256-258)GGA>GAA	p.G86E	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	86					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			AGCCAGATCGGACTCAGCCAG	0.632													0	0	0	0.013537	0	11	38										A	203276346	G	A	203276346	3	1	46	1	0	0	0	0	1	0	0	0	1554	1174	41	1	263	1	BTG2	1	203276346	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	958320	203276346	45974275	185	11882										
REN	5972	broad.mit.edu	37	chr1	204125005	204125005	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgcctcccaggtggaaagaGatgtcggggagtgtagggcc	17	8	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:204125005G>A	uc001haq.2	-	9	1046	c.1002C>T	c.(1000-1002)ATC>ATT	p.I334I		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	334					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGTGGAAAGAGATGTCGGGGA	0.567													0	0	0	0.00308	0	8	9										A	204125005	G	A	204125005	2	1	46	1	0	0	0	0	0	0	0	1	13224	932	33	1		1	REN	1	204125005	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	848659	204125005	45125616	186	11883										
CDK18	5129	broad.mit.edu	37	chr1	205498223	205498223	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacctcatctttcgcctcctCggtcagtctcccgctgctcc	6	20	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:205498223C>T	uc001hcr.2	+	11	1380	c.1161C>T	c.(1159-1161)CTC>CTT	p.L387L	CDK18_uc001hcp.2_Silent_p.L357L|CDK18_uc001hcq.2_Silent_p.L357L|CDK18_uc010prj.1_Silent_p.L268L|CDK18_uc001hcs.2_Silent_p.L268L|CDK18_uc009xbm.1_Silent_p.L282L|CDK18_uc001hct.2_5'Flank	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	355	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						TTCGCCTCCTCGGTCAGTCTC	0.706											OREG0014157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	1										T	205498223	C	T	205498223	2	4	46	1	0	0	0	0	0	0	0	1	3134	898	31	1		1	CDK18	1	205498223	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1373218	205498223	43752398	187	11884										
SLC41A1	254428	broad.mit.edu	37	chr1	205767810	205767810	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggctcactcagttccaggtaGagtccccagctgatgcctga	11	13	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:205767810G>A	uc001hdh.1	-	6	1703	c.831C>T	c.(829-831)CTC>CTT	p.L277L	SLC41A1_uc001hdg.1_5'Flank|uc001hdi.1_5'Flank	NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	277	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GTTCCAGGTAGAGTCCCCAGC	0.557													0	0	0	0.007413	0	19	87										A	205767810	G	A	205767810	2	1	46	1	0	0	0	0	0	0	0	1	14629	929	33	1		1	SLC41A1	1	205767810	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	269587	205767810	43482811	188	11885										
MAPKAPK2	9261	broad.mit.edu	37	chr1	206904547	206904547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctctccgggcatgaagactCgcatccgaatgggccagtat	11	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:206904547C>T	uc001hem.1	+	7	1118	c.832C>T	c.(832-834)CGC>TGC	p.R278C	MAPKAPK2_uc001hel.1_Missense_Mutation_p.R278C	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated	278	Protein kinase.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CATGAAGACTCGCATCCGAAT	0.537													0	0	0	0.010504	0	20	63										T	206904547	C	T	206904547	3	4	46	1	0	0	0	0	1	0	0	0	9289	884	31	1	858	1	MAPKAPK2	1	206904547	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1136737	206904547	42346074	189	11886										
C4BPA	722	broad.mit.edu	37	chr1	207317297	207317297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccaaagtatcacttgctctGggaacagaacctggtaccca	8	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:207317297G>A	uc001hfo.2	+	11	1773	c.1579G>A	c.(1579-1581)GGG>AGG	p.G527R		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	527	Sushi 8.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CACTTGCTCTGGGAACAGAAC	0.493													0	0	0	0.010818	0	32	51										A	207317297	G	A	207317297	3	1	46	1	0	0	0	0	1	0	0	0	2249	1348	47	2	1617	2	C4BPA	1	207317297	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	412750	207317297	41933324	190	11887										
NEK2	4751	broad.mit.edu	37	chr1	211842601	211842601	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcttctctcaagatttcttCtttgctcgtctgcaaccaaa	4	13	6	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:211842601C>T	uc001hir.1	-	6	985	c.839G>A	c.(838-840)AGA>AAA	p.R280K	NEK2_uc001hiq.1_Missense_Mutation_p.R280K|NEK2_uc001his.3_Missense_Mutation_p.R280K|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	280	Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		AAGATTTCTTCTTTGCTCGTC	0.408													0	0	0	0.00874	0	41	132										T	211842601	C	T	211842601	3	4	46	1	0	0	0	0	1	0	0	0	10324	913	32	1	510	1	NEK2	1	211842601	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4525304	211842601	37408020	191	11888										
INTS7	25896	broad.mit.edu	37	chr1	212118233	212118233	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccgtgctgaaccactccctCtacctttagcgccagctgct	7	17	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:212118233C>T	uc001hiw.1	-	19	2599	c.2494G>A	c.(2494-2496)GAG>AAG	p.E832K	INTS7_uc009xdb.1_Missense_Mutation_p.E812K|INTS7_uc001hix.1_Missense_Mutation_p.E708K|INTS7_uc001hiy.1_Missense_Mutation_p.E818K|INTS7_uc010pta.1_Missense_Mutation_p.E783K	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	832					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ACCACTCCCTCTACCTTTAGC	0.498													0	0	0	0.003954	0	26	80										T	212118233	C	T	212118233	3	4	46	1	0	0	0	0	1	0	0	0	7783	922	32	1	402	1	INTS7	1	212118233	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	275632	212118233	37132388	192	11889										
USH2A	7399	broad.mit.edu	37	chr1	216019244	216019244	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacagagataaagatccaatActctgtgtttggctttaggt	10	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:216019244A>G	uc001hku.1	-	45	9364	c.8977T>C	c.(8977-8979)TAT>CAT	p.Y2993H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2993	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGATCCAATACTCTGTGTTT	0.433										HNSCC(13;0.011)			0	0	0	0.003163	0	14	54										G	216019244	A	G	216019244	3	3	46	1	0	0	0	0	1	0	0	0	17033	391	14	5	6743	5	USH2A	1	216019244	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	3901011	216019244	33231377	193	11890										
EPRS	2058	broad.mit.edu	37	chr1	220146632	220146632	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatagcttgaagtttagtctCtgcctcattttcagcaactg	7	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:220146632C>G	uc001hly.1	-	29	4462	c.4192G>C	c.(4192-4194)GAG>CAG	p.E1398Q		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1398	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AGTTTAGTCTCTGCCTCATTT	0.433													0	0	0	0.00874	0	42	60										G	220146632	C	G	220146632	3	3	46	1	0	0	0	0	1	0	0	0	5191	922	32	1	362	1	EPRS	1	220146632	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4127388	220146632	29103989	194	11891										
HLX	3142	broad.mit.edu	37	chr1	221057702	221057702	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccgttctgaaggcgaggctGagagcgagagcagcgactcc	16	11	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:221057702G>A	uc001hmv.3	+	4	1580	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	375	Ser-rich.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		AGGCGAGGCTGAGAGCGAGAG	0.632													0	0	0	0.004007	0	11	13										A	221057702	G	A	221057702	3	1	46	1	0	0	0	0	1	0	0	0	7216	1291	45	1	1137	1	HLX	1	221057702	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	911070	221057702	28192919	195	11892										
DUSP10	11221	broad.mit.edu	37	chr1	221875931	221875931	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggtcatccgagtgtgcttCatcaagtaagcgatgacgat	11	8	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:221875931C>T	uc001hmy.1	-	4	1454	c.1272G>A	c.(1270-1272)ATG>ATA	p.M424I	DUSP10_uc001hmx.1_Missense_Mutation_p.M82I|DUSP10_uc001hmz.1_Missense_Mutation_p.M82I	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	424	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GAGTGTGCTTCATCAAGTAAG	0.507													0	0	0	0.01441	0	92	59										T	221875931	C	T	221875931	3	4	46	1	0	0	0	0	1	0	0	0	4810	826	29	1	180	1	DUSP10	1	221875931	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	818229	221875931	27374690	196	11893										
NVL	4931	broad.mit.edu	37	chr1	224492452	224492452	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actaacttttaatgtcatatCattgcctcccacatcttcaa	2	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:224492452C>T	uc001hok.2	-	8	854	c.811G>A	c.(811-813)GAT>AAT	p.D271N	NVL_uc001hol.2_Missense_Mutation_p.D165N|NVL_uc010pvd.1_Missense_Mutation_p.D180N|NVL_uc010pve.1_Missense_Mutation_p.D55N|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	271						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		AATGTCATATCATTGCCTCCC	0.343													0	0	0	0.01441	0	45	216										T	224492452	C	T	224492452	3	4	46	1	0	0	0	0	1	0	0	0	10780	826	29	1	1823	1	NVL	1	224492452	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2616521	224492452	24758169	197	11894										
OBSCN	84033	broad.mit.edu	37	chr1	228505341	228505341	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acgagctggtgcctggacccGagtgtgtggtggatggcctg	18	9	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:228505341G>A	uc009xez.1	+	52	13782	c.13738G>A	c.(13738-13740)GAG>AAG	p.E4580K	OBSCN_uc001hsn.2_Missense_Mutation_p.E4580K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4580	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCTGGACCCGAGTGTGTGGT	0.687													0	0	0	0.008291	0	10	17										A	228505341	G	A	228505341	3	1	46	1	0	0	0	0	1	0	0	0	10812	1059	37	1	13940	1	OBSCN	1	228505341	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4012889	228505341	20745280	198	11895										
TRIM11	81559	broad.mit.edu	37	chr1	228582712	228582712	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccgcggacagctcgcccttCtccttcctgttcacgttctc	7	19	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:228582712C>T	uc001hss.2	-	6	1356	c.1101G>A	c.(1099-1101)GAG>GAA	p.E367E	TRIM11_uc010pvx.1_Silent_p.E366E	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	367	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				GCTCGCCCTTCTCCTTCCTGT	0.647													0	0	0	0.003954	0	22	19										T	228582712	C	T	228582712	2	4	46	1	0	0	0	0	0	0	0	1	16484	912	32	1		1	TRIM11	1	228582712	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	77371	228582712	20667909	199	11896										
HIST3H2A	92815	broad.mit.edu	37	chr1	228645368	228645386	+	Frame_Shift_Del	DEL	AGACCGGGGCGCCGGCGCC	AGACCGGGGCGCCGGCGCC	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcgagcaccgcggccagatAgaccggggcgccggcgccca					rs143327597	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:228645368_228645386delAGACCGGGGCGCCGGCGCC	uc001hsy.2	-	1	175_193	c.133_151delGGCGCCGGCGCCCCGGTCT	c.(133-153)GGCGCCGGCGCCCCGGTCTATfs	p.G45fs	HIST3H2BB_uc001hsz.2_5'Flank	NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a	45_51					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				GCGGCCAGATAGACCGGGGCGCCGGCGCCCACGCGCTCC	0.703																		7	10	---	---								-	228645386	AGACCGGGGCGCCGGCGCC	-	228645368	7	5	46	1	0	1	0	1	0	0	0	0	7182	420	15	0	245	0	HIST3H2A	1	228645368	Frame_Shift_Del	DEL	AGACCGGGGCGCCGGCGCC	TCGA-DK-A1AC-01A-11D-A13W-08	62656	228645368	20605253	200	11897										
PGBD5	79605	broad.mit.edu	37	chr1	230486730	230486730	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgaagccagtggaagaacAttgtctgacccagaggctga	13	8	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:230486730A>G	uc010pwb.1	-	3	661	c.661T>C	c.(661-663)TGT>CGT	p.C221R	PGBD5_uc001htv.2_Missense_Mutation_p.C320R	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	221						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GTGGAAGAACATTGTCTGACC	0.567													0	0	0	0.003954	0	24	58										G	230486730	A	G	230486730	3	3	46	1	0	0	0	0	1	0	0	0	11784	217	8	5	726	5	PGBD5	1	230486730	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1841362	230486730	18763891	201	11898										
AGT	183	broad.mit.edu	37	chr1	230845940	230845940	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctgcacaaacggctgcttCaggtgcaggcctggggctgt	14	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:230845940C>T	uc001hty.3	-	2	1165	c.657G>A	c.(655-657)CTG>CTA	p.L219L	AGT_uc009xfe.2_Silent_p.L219L|AGT_uc009xff.2_Silent_p.L191L	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	219					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	ACGGCTGCTTCAGGTGCAGGC	0.617													0	0	0	0.004007	0	16	23										T	230845940	C	T	230845940	2	4	46	1	0	0	0	0	0	0	0	1	399	813	29	1		1	AGT	1	230845940	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	359210	230845940	18404681	202	11899										
GNG4	2786	broad.mit.edu	37	chr1	235747067	235747067	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgtccatacaggcttccatCtttagctgctccacagcttt	6	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:235747067C>G	uc001hxe.3	-	3	526	c.72G>C	c.(70-72)AAG>AAC	p.K24N	GNG4_uc009xfz.2_Missense_Mutation_p.K24N|GNG4_uc001hxh.3_Missense_Mutation_p.K24N	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	24					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			AGGCTTCCATCTTTAGCTGCT	0.512													0	0	0	0.01441	0	79	69										G	235747067	C	G	235747067	3	3	46	1	0	0	0	0	1	0	0	0	6529	912	32	1	163	1	GNG4	1	235747067	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4901127	235747067	13503554	203	11900										
GNG4	2786	broad.mit.edu	37	chr1	235747078	235747078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcttccatctttagctgctCcacagctttcctggcttggg	10	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:235747078C>T	uc001hxe.3	-	3	515	c.61G>A	c.(61-63)GAG>AAG	p.E21K	GNG4_uc009xfz.2_Missense_Mutation_p.E21K|GNG4_uc001hxh.3_Missense_Mutation_p.E21K	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	21					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			TTTAGCTGCTCCACAGCTTTC	0.507													0	0	0	0.01441	0	89	76										T	235747078	C	T	235747078	3	4	46	1	0	0	0	0	1	0	0	0	6529	864	30	1	174	1	GNG4	1	235747078	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	11	235747078	13503543	204	11901										
NID1	4811	broad.mit.edu	37	chr1	236228224	236228224	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctccagggcaggagagacGaagtcatccccgtcctccag	12	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:236228224G>A	uc001hxo.2	-	1	258	c.156C>T	c.(154-156)TTC>TTT	p.F52F	NID1_uc009xgd.2_Silent_p.F52F|uc001hxp.1_Missense_Mutation_p.R122Q	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	52					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CAGGAGAGACGAAGTCATCCC	0.697													0	0	0	0.010729	0	11	6										A	236228224	G	A	236228224	2	1	46	1	0	0	0	0	0	0	0	1	10414	1049	37	1		1	NID1	1	236228224	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	481146	236228224	13022397	205	11902										
HEATR1	55127	broad.mit.edu	37	chr1	236738083	236738083	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taaaagggaaactgaaaattCattatactttcccagagtga	7	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:236738083C>G	uc001hyd.1	-	23	3330	c.3205G>C	c.(3205-3207)GAA>CAA	p.E1069Q	HEATR1_uc009xgh.1_Intron	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1069					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACTGAAAATTCATTATACTTT	0.428													0	0	0	0.00874	0	42	39										G	236738083	C	G	236738083	3	3	46	1	0	0	0	0	1	0	0	0	7027	835	29	1	3321	1	HEATR1	1	236738083	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	509859	236738083	12512538	206	11903										
SDCCAG8	10806	broad.mit.edu	37	chr1	243480080	243480080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagagatgacttgatgtctgCactagtttccgtaaggagca	11	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:243480080C>T	uc001hzw.2	+	9	1109	c.953C>T	c.(952-954)GCA>GTA	p.A318V	SDCCAG8_uc010pyk.1_Missense_Mutation_p.A173V|SDCCAG8_uc010pyl.1_Missense_Mutation_p.A130V|SDCCAG8_uc001hzx.2_Missense_Mutation_p.A130V	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	318	Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TTGATGTCTGCACTAGTTTCC	0.413													0	0	0	0.00632	0	28	50										T	243480080	C	T	243480080	3	4	46	1	0	0	0	0	1	0	0	0	13959	710	25	2	987	2	SDCCAG8	1	243480080	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6741997	243480080	5770541	207	11904										
ZNF238	10472	broad.mit.edu	37	chr1	244218572	244218572	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acacattcgcaagttccactGtgagttggtgaactccttgt	9	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:244218572G>C	uc001iae.2	+	1	1991	c.1469G>C	c.(1468-1470)TGT>TCT	p.C490S	ZNF238_uc001iad.3_Missense_Mutation_p.C499S|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	490					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			AAGTTCCACTGTGAGTTGGTG	0.547													0	0	0	0.014323	0	21	71										C	244218572	G	C	244218572	3	2	46	1	0	0	0	0	1	0	0	0	17787	1377	48	4	1502	4	ZNF238	1	244218572	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	738492	244218572	5032049	208	11905										
KIF26B	55083	broad.mit.edu	37	chr1	245851077	245851077	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcccaaagggactccccctCtgccccctgtccgaaagtcc	9	19	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:245851077C>G	uc001ibf.1	+	12	5232	c.4792C>G	c.(4792-4794)CTG>GTG	p.L1598V	KIF26B_uc001ibg.1_Missense_Mutation_p.L1216V|KIF26B_uc001ibh.1_Missense_Mutation_p.L840V	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1598					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GACTCCCCCTCTGCCCCCTGT	0.687													0	0	0	0.004672	0	3	1										G	245851077	C	G	245851077	3	3	46	1	0	0	0	0	1	0	0	0	8295	912	32	1	4838	1	KIF26B	1	245851077	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1632505	245851077	3399544	209	11906										
TFB2M	64216	broad.mit.edu	37	chr1	246729307	246729307	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagctgcggagaggagtcaGagagcccacagtggttcctc	14	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:246729307G>A	uc001ibn.2	-	1	259	c.134C>T	c.(133-135)TCT>TTT	p.S45F	CNST_uc001ibo.3_5'Flank|CNST_uc001ibp.2_5'Flank|TFB2M_uc010pys.1_RNA	NM_022366	NP_071761	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	45					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			AGAGGAGTCAGAGAGCCCACA	0.592													0	0	0	0.003163	0	14	60										A	246729307	G	A	246729307	3	1	46	1	0	0	0	0	1	0	0	0	15791	942	33	1	1088	1	TFB2M	1	246729307	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	878230	246729307	2521314	210	11907										
TRIM58	25893	broad.mit.edu	37	chr1	248039263	248039263	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcttgaccgccgacctgcgCagtgtgcaggatggagaacc	13	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:248039263C>T	uc001ido.2	+	6	981	c.933C>T	c.(931-933)CGC>CGT	p.R311R	OR2W3_uc001idp.1_5'UTR	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	311	B30.2/SPRY.					intracellular	zinc ion binding	p.R311C(1)		skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCGACCTGCGCAGTGTGCAGG	0.572													0	0	0	0.00499	0	16	30										T	248039263	C	T	248039263	2	4	46	1	0	0	0	0	0	0	0	1	16528	697	25	2		2	TRIM58	1	248039263	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1309956	248039263	1211358	211	11908										
OR2T3	343173	broad.mit.edu	37	chr1	248637237	248637237	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgaagctctcctgctctGacgtctccctctataagacg	8	14	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:248637237G>A	uc001iel.1	+	1	586	c.586G>A	c.(586-588)GAC>AAC	p.D196N		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCCTGCTCTGACGTCTCCCT	0.522													0	0	0	0.01441	0	76	93										A	248637237	G	A	248637237	3	1	46	1	0	0	0	0	1	0	0	0	11023	1290	45	1	588	1	OR2T3	1	248637237	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	597974	248637237	613384	212	11909										
MYT1L	23040	broad.mit.edu	37	chr2	1893096	1893096	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagtcccagcagtcgccctCgcccagctggaaacaccggt	10	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:1893096C>T	uc002qxe.2	-	16	3264	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	MYT1L_uc002qxd.2_Missense_Mutation_p.E811K|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	813					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CAGTCGCCCTCGCCCAGCTGG	0.587													0	0	0	0.00278	0	23	92										T	1893096	C	T	1893096	3	4	46	1	0	0	0	0	1	0	0	0	10107	893	31	1	1163	1	MYT1L	2	1893096	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		1893096	241306277	213	11910										
ASAP2	8853	broad.mit.edu	37	chr2	9540887	9540887	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagtggatctctctgcaacGgaagctctgggtcctctgtc	11	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:9540887G>A	uc002qzh.2	+	26	3091	c.2751G>A	c.(2749-2751)ACG>ACA	p.T917T	ASAP2_uc002qzi.2_Silent_p.T872T	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	917	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						TCTCTGCAACGGAAGCTCTGG	0.532													0	0	0	0.010729	0	11	62										A	9540887	G	A	9540887	2	1	46	1	0	0	0	0	0	0	0	1	1011	1103	39	2		2	ASAP2	2	9540887	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7647791	9540887	233658486	214	11911										
ITGB1BP1	9270	broad.mit.edu	37	chr2	9552439	9552439	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatcaggtctaatggcccttCaaggccttttccctcggaga	9	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:9552439C>G	uc002qzj.2	-	4	424	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	ITGB1BP1_uc002qzk.2_Missense_Mutation_p.E83Q|ITGB1BP1_uc002qzl.2_RNA|ITGB1BP1_uc002qzm.2_RNA|ITGB1BP1_uc010yiy.1_Missense_Mutation_p.E39Q|ITGB1BP1_uc002qzn.1_Missense_Mutation_p.E83Q	NM_004763	NP_004754	O14713	ITBP1_HUMAN	integrin cytoplasmic domain-associated protein 1	83	PID.				cell migration|cell-matrix adhesion|intracellular protein kinase cascade	cytosol|lamellipodium|membrane|ruffle	protein binding|protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.23)		AATGGCCCTTCAAGGCCTTTT	0.403													0	0	0	0.00278	0	25	124										G	9552439	C	G	9552439	3	3	46	1	0	0	0	0	1	0	0	0	7891	835	29	1	371	1	ITGB1BP1	2	9552439	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	11552	9552439	233646934	215	11912										
ADAM17	6868	broad.mit.edu	37	chr2	9695720	9695720	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accacgctggtcaggaatagGagagactgcctcatgttccc	11	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:9695720G>A	uc002qzu.2	-	1	198	c.15C>T	c.(13-15)CTC>CTT	p.L5L	ADAM17_uc010ewy.2_Silent_p.L5L|ADAM17_uc010ewz.2_Silent_p.L5L|ADAM17_uc010exb.1_Silent_p.L5L|ADAM17_uc002qzv.2_Silent_p.L5L	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	5					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TCAGGAATAGGAGAGACTGCC	0.647											OREG0014419	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	3	10										A	9695720	G	A	9695720	2	1	46	1	0	0	0	0	0	0	0	1	238	1161	41	1		1	ADAM17	2	9695720	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	143281	9695720	233503653	216	11913										
GRHL1	29841	broad.mit.edu	37	chr2	10101494	10101494	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagttcagctctggtgctCaagccccaaatgctcaaagg	9	13	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:10101494C>T	uc002raa.2	+	4	769	c.598C>T	c.(598-600)CAA>TAA	p.Q200*	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Silent_p.L36L|GRHL1_uc010yjb.1_Nonsense_Mutation_p.Q49*	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	200					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CTCTGGTGCTCAAGCCCCAAA	0.522													0	0	0	0.009718	0	40	143										T	10101494	C	T	10101494	4	4	46	1	0	0	0	0	0	1	0	0	6763	827	29	1	612	1	GRHL1	2	10101494	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	405774	10101494	233097879	217	11914										
KLF11	8462	broad.mit.edu	37	chr2	10187963	10187963	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggagccagtgcccagctctCcctgcagggccaaggggact	14	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:10187963C>T	uc002raf.1	+	3	661	c.499C>T	c.(499-501)CCC>TCC	p.P167S	KLF11_uc010yjc.1_Missense_Mutation_p.P150S	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	167					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GCCCAGCTCTCCCTGCAGGGC	0.637													0	0	0	0.014323	0	23	79										T	10187963	C	T	10187963	3	4	46	1	0	0	0	0	1	0	0	0	8339	855	30	1	509	1	KLF11	2	10187963	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	86469	10187963	233011410	218	11915										
HPCAL1	3241	broad.mit.edu	37	chr2	10559935	10559935	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggtgctgcaggacctgcggGagaacacggagttcaccgac	15	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:10559935G>A	uc002raj.2	+	3	426	c.52G>A	c.(52-54)GAG>AAG	p.E18K	HPCAL1_uc002rak.2_Missense_Mutation_p.E18K|HPCAL1_uc002ral.2_Missense_Mutation_p.E18K|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Missense_Mutation_p.E18K	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	18							calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		GGACCTGCGGGAGAACACGGA	0.647													0	0	0	0.013726	0	31	10										A	10559935	G	A	10559935	3	1	46	1	0	0	0	0	1	0	0	0	7330	1175	41	1	54	1	HPCAL1	2	10559935	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	371972	10559935	232639438	219	11916										
LPIN1	23175	broad.mit.edu	37	chr2	11964910	11964910	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaggacattcattctgcctCagcgtaaaatgtcccaagca	7	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:11964910C>T	uc010yjn.1	+	21	2940	c.2666C>T	c.(2665-2667)TCA>TTA	p.S889L	LPIN1_uc010yjm.1_Missense_Mutation_p.S974L|LPIN1_uc002rbt.2_Missense_Mutation_p.S889L|LPIN1_uc010yjo.1_Missense_Mutation_p.S390L	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	889					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CATTCTGCCTCAGCGTAAAAT	0.517													0	0	0	0.01441	0	63	34										T	11964910	C	T	11964910	3	4	46	1	0	0	0	0	1	0	0	0	8918	838	29	1	2740	1	LPIN1	2	11964910	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1404975	11964910	231234463	220	11917										
NBAS	51594	broad.mit.edu	37	chr2	15415689	15415689	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggagacgatcaaagtacttCatgcagacatcataggcatg	10	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:15415689C>T	uc002rcc.1	-	44	5669	c.5643G>A	c.(5641-5643)ATG>ATA	p.M1881I	NBAS_uc010exl.1_Missense_Mutation_p.M953I|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1881										ovary(2)|liver(1)|skin(1)	4						CAAAGTACTTCATGCAGACAT	0.448													0	0	0	0.01441	0	65	25										T	15415689	C	T	15415689	3	4	46	1	0	0	0	0	1	0	0	0	10186	826	29	1	1508	1	NBAS	2	15415689	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3450779	15415689	227783684	221	11918										
APOB	338	broad.mit.edu	37	chr2	21233209	21233209	+	Silent	SNP	A	A	G													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tactgatcaaattgtatcatAtatgtctgcagttgagatag							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:21233209A>G	uc002red.2	-	26	6659	c.6531T>C	c.(6529-6531)TAT>TAC	p.Y2177Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2177	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATTGTATCATATATGTCTGCA	0.234													0	0	0	0.01441	0	50	31										G	21233209	A	G	21233209	2	3	46	1	0	0	0	0	0	0	0	1	785	456	16	5		5	APOB	2	21233209	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	5817520	21233209	221966164	222	11919	56	2								
APOB	338	broad.mit.edu	37	chr2	21233218	21233218	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aattgtatcatatatgtctgCagttgagatagtttttcatt							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:21233218C>T	uc002red.2	-	26	6650	c.6522G>A	c.(6520-6522)CTG>CTA	p.L2174L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2174	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATATGTCTGCAGTTGAGATA	0.254													0	0	0	0.01441	0	45	31										T	21233218	C	T	21233218	2	4	46	1	0	0	0	0	0	0	0	1	785	697	25	2		2	APOB	2	21233218	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9	21233218	221966155	223	11920	56	2								
MFSD2B	388931	broad.mit.edu	37	chr2	24236211	24236211	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgtgctatggcattggtggGgtccccaaccagatagcctc	13	11	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:24236211G>A	uc002reo.1	+	2	167	c.153G>A	c.(151-153)GGG>GGA	p.G51G	MFSD2B_uc010exz.1_RNA	NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	51					transport	integral to membrane				ovary(2)	2						GCATTGGTGGGGTCCCCAACC	0.547													0	0	0	0.000602	0	5	19										A	24236211	G	A	24236211	2	1	46	1	0	0	0	0	0	0	0	1	9531	1219	43	2		2	MFSD2B	2	24236211	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3002993	24236211	218963162	224	11921										
C2orf84	653140	broad.mit.edu	37	chr2	24398440	24398440	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgagtccgtttctttaatgGaggtgagataacgtggcgtt	13	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:24398440G>C	uc002rfc.2	+	2	177	c.91G>C	c.(91-93)GAG>CAG	p.E31Q	C2orf84_uc010eyc.2_RNA	NM_001040710	NP_001035800	Q86W67	CB084_HUMAN	hypothetical protein LOC653140	31											0						TTCTTTAATGGAGGTGAGATA	0.483													0	0	0	0.009535	0	32	30										C	24398440	G	C	24398440	3	2	46	1	0	0	0	0	1	0	0	0	2199	1175	41	1	93	1	C2orf84	2	24398440	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	162229	24398440	218800933	225	11922										
ADCY3	109	broad.mit.edu	37	chr2	25047259	25047259	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccctcacctcatctctcttCttggaccccaggaaatggcg	7	17	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:25047259C>T	uc002rfs.3	-	16	2923	c.2724G>A	c.(2722-2724)AAG>AAA	p.K908K	ADCY3_uc002rfr.3_Silent_p.K495K|ADCY3_uc010ykm.1_Silent_p.K909K	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	908	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CATCTCTCTTCTTGGACCCCA	0.582													0	0	0	0.006999	0	40	27										T	25047259	C	T	25047259	2	4	46	1	0	0	0	0	0	0	0	1	295	912	32	1		1	ADCY3	2	25047259	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	648819	25047259	218152114	226	11923										
DTNB	1838	broad.mit.edu	37	chr2	25705718	25705718	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggctaaccatggtgtcattCatattagtcagagggcgagg	13	7	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:25705718C>T	uc002rgh.2	-	10	1276	c.1026G>A	c.(1024-1026)ATG>ATA	p.M342I	DTNB_uc002rgg.2_Missense_Mutation_p.M1I|DTNB_uc010yko.1_Missense_Mutation_p.M285I|DTNB_uc010ykp.1_Missense_Mutation_p.M138I|DTNB_uc002rgo.2_Missense_Mutation_p.M163I|DTNB_uc002rgi.2_Missense_Mutation_p.M342I|DTNB_uc002rgj.2_Missense_Mutation_p.M342I|DTNB_uc002rgk.2_Missense_Mutation_p.M342I|DTNB_uc002rgl.2_Missense_Mutation_p.M342I|DTNB_uc002rgq.2_Missense_Mutation_p.M342I|DTNB_uc002rgm.2_Missense_Mutation_p.M342I|DTNB_uc002rgn.2_Missense_Mutation_p.M138I|DTNB_uc002rgr.1_Missense_Mutation_p.M331I|DTNB_uc010ykq.1_Missense_Mutation_p.M195I	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	342						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGTGTCATTCATATTAGTCA	0.468													0	0	0	0.01441	0	45	29										T	25705718	C	T	25705718	3	4	46	1	0	0	0	0	1	0	0	0	4789	826	29	1	901	1	DTNB	2	25705718	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	658459	25705718	217493655	227	11924										
ASXL2	55252	broad.mit.edu	37	chr2	26029124	26029124	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtatatactcccattctacCtggaaccttatagaagatgc	6	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:26029124C>T	uc002rgs.2	-	3	447	c.226G>A	c.(226-228)GGT>AGT	p.G76S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	76					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCATTCTACCTGGAACCTTA	0.398													0	0	0	0.000602	0	5	36										T	26029124	C	T	26029124	3	4	46	1	0	0	0	0	1	0	0	0	1067	681	24	2	4121	2	ASXL2	2	26029124	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	323406	26029124	217170249	228	11925										
OTOF	9381	broad.mit.edu	37	chr2	26726693	26726693	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttgccgagcttcatggcgGagaacacgctcctcccggct	11	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:26726693G>A	uc002rhk.2	-	6	657	c.530C>T	c.(529-531)TCC>TTC	p.S177F	OTOF_uc010ylb.1_RNA	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	177	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTCATGGCGGAGAACACGCT	0.632													0	0	0	0.003163	0	16	77										A	26726693	G	A	26726693	3	1	46	1	0	0	0	0	1	0	0	0	11303	1174	41	1	5956	1	OTOF	2	26726693	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	697569	26726693	216472680	229	11926										
TMEM214	54867	broad.mit.edu	37	chr2	27258840	27258840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaatgtgtatctctccagggGagtcactacatggttaccgc	11	10	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27258840G>A	uc002ria.3	+	5	750	c.640G>A	c.(640-642)GAG>AAG	p.E214K	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.E169K	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	214						integral to membrane	protein binding				0						CTCTCCAGGGGAGTCACTACA	0.527													0	0	0	0.00245	0	12	81										A	27258840	G	A	27258840	3	1	46	1	0	0	0	0	1	0	0	0	16134	1175	41	1	658	1	TMEM214	2	27258840	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	532147	27258840	215940533	230	11927										
SLC5A6	8884	broad.mit.edu	37	chr2	27427346	27427346	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacctggtctggggctgcctGagcctgctgaatgctcatgg	14	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27427346G>C	uc002rjd.2	-	9	1379	c.988C>G	c.(988-990)CAG>GAG	p.Q330E	SLC5A6_uc010eyv.1_Missense_Mutation_p.Q330E	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	330					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	GGGGCTGCCTGAGCCTGCTGA	0.572													0	0	0	0.00245	0	14	73										C	27427346	G	C	27427346	3	2	46	1	0	0	0	0	1	0	0	0	14669	1299	45	1	955	1	SLC5A6	2	27427346	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	168506	27427346	215772027	231	11928										
SLC5A6	8884	broad.mit.edu	37	chr2	27430496	27430496	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggttggggaaagaggggctGaggtgctcacccctacactc	15	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27430496G>T	uc002rjd.2	-	3	414	c.23C>A	c.(22-24)TCA>TAA	p.S8*	SLC5A6_uc010eyv.1_Nonsense_Mutation_p.S8*|SLC5A6_uc002rje.1_Nonsense_Mutation_p.S8*	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	8					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	AAGAGGGGCTGAGGTGCTCAC	0.587													1	0	1.58986e-06	0.008291	1.63198e-06	10	57										T	27430496	G	T	27430496	4	4	46	1	0	0	0	0	0	1	0	0	14669	1294	45	3	1944	3	SLC5A6	2	27430496	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3150	27430496	215768877	232	11929										
CAD	790	broad.mit.edu	37	chr2	27463781	27463781	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcttgtcctgtttgcagctGaggagccaaaggagaagtcc	12	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27463781G>A	uc002rji.2	+	36	5758	c.5596G>A	c.(5596-5598)GAG>AAG	p.E1866K	CAD_uc010eyw.2_Missense_Mutation_p.E1803K	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1866	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GTTTGCAGCTGAGGAGCCAAA	0.502													0	0	0	0.003954	0	27	22										A	27463781	G	A	27463781	3	1	46	1	0	0	0	0	1	0	0	0	2565	1291	45	1	5738	1	CAD	2	27463781	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	33285	27463781	215735592	233	11930										
PPM1G	5496	broad.mit.edu	37	chr2	27605009	27605009	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcacctcttccacaatggatGacaataaccgaagctcccca	5	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27605009G>A	uc002rkl.2	-	10	1525	c.1418C>T	c.(1417-1419)TCA>TTA	p.S473L	ZNF513_uc002rkj.2_5'Flank|ZNF513_uc002rkk.2_5'Flank|PPM1G_uc002rkm.2_Missense_Mutation_p.S254L	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	473					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					CACAATGGATGACAATAACCG	0.483													0	0	0	0.004007	0	16	71										A	27605009	G	A	27605009	3	1	46	1	0	0	0	0	1	0	0	0	12340	1294	45	1	230	1	PPM1G	2	27605009	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	141228	27605009	215594364	234	11931										
BRE	9577	broad.mit.edu	37	chr2	28152708	28152708	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attttttaaagctgcacatcAttgactcctgggcccaactg	7	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:28152708A>G	uc002rlr.2	+	4	456	c.138A>G	c.(136-138)TCA>TCG	p.S46S	BRE_uc002rlp.1_Silent_p.S46S|BRE_uc002rlq.2_Silent_p.S46S|BRE_uc002rls.2_Silent_p.S46S|BRE_uc002rlt.2_Silent_p.S46S|BRE_uc002rlu.2_Silent_p.S46S|BRE_uc002rlv.2_5'UTR	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	46	UEV-like 1.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCTGCACATCATTGACTCCTG	0.323													0	0	0	0.004656	0	25	109										G	28152708	A	G	28152708	2	3	46	1	0	0	0	0	0	0	0	1	1509	204	8	5		5	BRE	2	28152708	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	547699	28152708	215046665	235	11932										
FOSL2	2355	broad.mit.edu	37	chr2	28634949	28634950	+	Frame_Shift_Ins	INS	-	-	CT													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatcgcccccagcccctgggINSctgcagcccatgcgcagtgg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:28634949_28634950insCT	uc002rma.2	+	4	1424_1425	c.615_616insCT	c.(613-618)GGGCTGfs	p.G205fs	FOSL2_uc010ymi.1_Frame_Shift_Ins_p.G166fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	205_206					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CAGCCCCTGGGCTGCAGCCCAT	0.663																		23	93	---	---								CT	28634950	-	CT	28634949	7	5	46	1	0	1	1	0	0	0	0	0	5988	1190	42	0	629	0	FOSL2	2	28634949	Frame_Shift_Ins	INS	-	TCGA-DK-A1AC-01A-11D-A13W-08	482241	28634949	214564424	236	11933										
C2orf71	388939	broad.mit.edu	37	chr2	29295005	29295005	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcctcactgacctctcctGatgggatggcatttggaagc	11	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:29295005G>C	uc002rmt.1	-	1	2123	c.2123C>G	c.(2122-2124)TCA>TGA	p.S708*		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	708					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GACCTCTCCTGATGGGATGGC	0.507													0	0	0	0.010504	0	19	135										C	29295005	G	C	29295005	4	2	46	1	0	0	0	0	0	1	0	0	2191	1294	45	1	1751	1	C2orf71	2	29295005	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	660056	29295005	213904368	237	11934										
CLIP4	79745	broad.mit.edu	37	chr2	29354254	29354254	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caacaaaacattgacattatTggaaatgaggtaaggaattc	8	5	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:29354254T>C	uc002rmv.2	+	3	503	c.264T>C	c.(262-264)ATT>ATC	p.I88I	CLIP4_uc002rmu.2_Silent_p.I88I|CLIP4_uc010ezm.1_Silent_p.I88I|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Silent_p.I70I	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	88	ANK 1.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TTGACATTATTGGAAATGAGG	0.338													0	0	0	0.001168	0	6	189										C	29354254	T	C	29354254	2	2	46	1	0	0	0	0	0	0	0	1	3535	1800	63	5		5	CLIP4	2	29354254	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	59249	29354254	213845119	238	11935										
XDH	7498	broad.mit.edu	37	chr2	31587029	31587029	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaggtcctactcacactctGagagagatcctgggtgttcc	11	12	2	2	rs140982129		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:31587029G>A	uc002rnv.1	-	24	2705	c.2626C>T	c.(2626-2628)CAG>TAG	p.Q876*		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	876					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTCACACTCTGAGAGAGATCC	0.572													0	0	0	0.00308	0	8	54										A	31587029	G	A	31587029	4	1	46	1	0	0	0	0	0	1	0	0	17423	1299	45	1	1427	1	XDH	2	31587029	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2232775	31587029	211612344	239	11936										
BIRC6	57448	broad.mit.edu	37	chr2	32640622	32640622	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gactgcggacatgccctgttGaatccttgagtgcaataaat	10	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:32640622G>A	uc010ezu.2	+	10	2397	c.2263G>A	c.(2263-2265)GAA>AAA	p.E755K		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	755					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATGCCCTGTTGAATCCTTGAG	0.398													0	0	0	0.00245	0	14	79										A	32640622	G	A	32640622	3	1	46	1	0	0	0	0	1	0	0	0	1438	1291	45	1	2301	1	BIRC6	2	32640622	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1053593	32640622	210558751	240	11937										
BIRC6	57448	broad.mit.edu	37	chr2	32743450	32743450	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaaagtgacaatgtttcttCagtctccatgtccagtgagt	9	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:32743450C>T	uc010ezu.2	+	56	11613	c.11479C>T	c.(11479-11481)CAG>TAG	p.Q3827*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3827					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AATGTTTCTTCAGTCTCCATG	0.368													0	0	0	0.003163	0	15	79										T	32743450	C	T	32743450	4	4	46	1	0	0	0	0	0	1	0	0	1438	827	29	1	11701	1	BIRC6	2	32743450	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	102828	32743450	210455923	241	11938										
BIRC6	57448	broad.mit.edu	37	chr2	32770731	32770731	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatattcttcaatctccatCagccaatgtgcttccaaccc	3	15	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:32770731C>T	uc010ezu.2	+	63	12748	c.12614C>T	c.(12613-12615)TCA>TTA	p.S4205L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4205					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CAATCTCCATCAGCCAATGTG	0.393													0	0	0	0.01441	0	56	288										T	32770731	C	T	32770731	3	4	46	1	0	0	0	0	1	0	0	0	1438	838	29	1	12864	1	BIRC6	2	32770731	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	27281	32770731	210428642	242	11939										
GALM	130589	broad.mit.edu	37	chr2	38960689	38960689	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatgaccacaccacctggttCaagttttctgtggcttaagg	9	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:38960689C>T	uc002rqy.2	+	7	1263	c.1011C>T	c.(1009-1011)TTC>TTT	p.F337F		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	337					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				CCACCTGGTTCAAGTTTTCTG	0.527													0	0	0	0.01441	0	88	104										T	38960689	C	T	38960689	2	4	46	1	0	0	0	0	0	0	0	1	6205	825	29	1		1	GALM	2	38960689	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6189958	38960689	204238684	243	11940										
SLC3A1	6519	broad.mit.edu	37	chr2	44539852	44539852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggagaagaaattggaatggGaaatattgtagccgcaaatc	12	4	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:44539852G>A	uc002ruc.3	+	8	1538	c.1460G>A	c.(1459-1461)GGA>GAA	p.G487E	SLC3A1_uc002rtz.2_Missense_Mutation_p.G487E|SLC3A1_uc002rua.2_Missense_Mutation_p.G487E|SLC3A1_uc002rub.2_Missense_Mutation_p.G487E|SLC3A1_uc002rud.3_Missense_Mutation_p.G209E|SLC3A1_uc002rue.3_Missense_Mutation_p.G107E	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	487	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	ATTGGAATGGGAAATATTGTA	0.353													0	0	0	0.006214	0	9	65										A	44539852	G	A	44539852	3	1	46	1	0	0	0	0	1	0	0	0	14626	1174	41	1	1490	1	SLC3A1	2	44539852	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5579163	44539852	198659521	244	11941										
ERLEC1	27248	broad.mit.edu	37	chr2	54028617	54028617	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaccttgtagtttgaaacaGaaccggcccagatcaagtac	8	11	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:54028617G>A	uc002rxl.2	+	7	889	c.609G>A	c.(607-609)CAG>CAA	p.Q203Q	ASB3_uc002rxi.3_Intron|ERLEC1_uc002rxm.2_Silent_p.Q203Q|ERLEC1_uc002rxn.2_Silent_p.Q203Q	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	203					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						GTTTGAAACAGAACCGGCCCA	0.373													0	0	0	0.01441	0	47	88										A	54028617	G	A	54028617	2	1	46	1	0	0	0	0	0	0	0	1	5231	933	33	1		1	ERLEC1	2	54028617	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	9488765	54028617	189170756	245	11942										
SPTBN1	6711	broad.mit.edu	37	chr2	54882285	54882285	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgcacgtaatgacagtttCacaacctgcattgaacttgg	9	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:54882285C>T	uc002rxu.2	+	28	6150	c.5901C>T	c.(5899-5901)TTC>TTT	p.F1967F	SPTBN1_uc002rxx.2_Silent_p.F1954F|SPTBN1_uc002rxy.2_Silent_p.F112F|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1967	Spectrin 16.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ATGACAGTTTCACAACCTGCA	0.423													0	0	0	0.001855	0	14	67										T	54882285	C	T	54882285	2	4	46	1	0	0	0	0	0	0	0	1	15118	825	29	1		1	SPTBN1	2	54882285	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	853668	54882285	188317088	246	11943										
RTN4	57142	broad.mit.edu	37	chr2	55252388	55252388	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaaacatctggaggcaataaGagcacctttgatgtagcaga	11	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:55252388G>C	uc002rye.2	-	3	3145	c.2847C>G	c.(2845-2847)CTC>CTG	p.L949L	RTN4_uc002ryd.2_Silent_p.L743L|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	949	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GAGGCAATAAGAGCACCTTTG	0.393													0	0	0	0.01441	0	94	92										C	55252388	G	C	55252388	2	2	46	1	0	0	0	0	0	0	0	1	13728	929	33	1		1	RTN4	2	55252388	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	370103	55252388	187946985	247	11944										
RTN4	57142	broad.mit.edu	37	chr2	55253818	55253818	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatgtttgttgcaatgctctCagttgctgctgggttaaagg	12	6	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:55253818C>T	uc002rye.2	-	3	1715	c.1417G>A	c.(1417-1419)GAG>AAG	p.E473K	RTN4_uc002ryd.2_Missense_Mutation_p.E267K|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	473	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GCAATGCTCTCAGTTGCTGCT	0.388													0	0	0	0.01441	0	131	215										T	55253818	C	T	55253818	3	4	46	1	0	0	0	0	1	0	0	0	13728	835	29	1	2227	1	RTN4	2	55253818	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1430	55253818	187945555	248	11945										
MTIF2	4528	broad.mit.edu	37	chr2	55471226	55471226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtctctccagcctgtaattCccactggcatgctgggatag	11	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:55471226C>T	uc002ryn.2	-	12	1987	c.1250G>A	c.(1249-1251)GGA>GAA	p.G417E	MTIF2_uc010yox.1_Missense_Mutation_p.G86E|MTIF2_uc002ryo.2_Missense_Mutation_p.G417E	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	417					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						GCCTGTAATTCCCACTGGCAT	0.393													0	0	0	0.01441	0	47	40										T	55471226	C	T	55471226	3	4	46	1	0	0	0	0	1	0	0	0	9934	855	30	1	957	1	MTIF2	2	55471226	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	217408	55471226	187728147	249	11946										
BCL11A	53335	broad.mit.edu	37	chr2	60688925	60688925	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aactcgcatgacttggacttGaccgggggctgggagggagg	18	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:60688925G>C	uc002sae.1	-	4	1350	c.1122C>G	c.(1120-1122)GTC>GTG	p.V374V	BCL11A_uc002sab.2_Silent_p.V374V|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Silent_p.V340V|BCL11A_uc002sad.1_Silent_p.V222V|BCL11A_uc002saf.1_Silent_p.V340V	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	374					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACTTGGACTTGACCGGGGGCT	0.632			T	IGH@	B-CLL								0	0	0	0.008361	0	30	80										C	60688925	G	C	60688925	2	2	46	1	0	0	0	0	0	0	0	1	1363	1277	45	1		1	BCL11A	2	60688925	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5217699	60688925	182510448	250	11947										
B3GNT2	10678	broad.mit.edu	37	chr2	62449761	62449761	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactgcttatagatcagccgGataagtgtgcaaagaaacct	9	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:62449761G>C	uc002sbs.2	+	2	644	c.406G>C	c.(406-408)GAT>CAT	p.D136H		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	136	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			AGATCAGCCGGATAAGTGTGC	0.463													0	0	0	0.013114	0	44	257										C	62449761	G	C	62449761	3	2	46	1	0	0	0	0	1	0	0	0	1257	1174	41	1	408	1	B3GNT2	2	62449761	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1760836	62449761	180749612	251	11948										
OTX1	5013	broad.mit.edu	37	chr2	63282997	63282997	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccgcgcctagcaacacctCgtgtatgcagcgctccgtag	12	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:63282997C>T	uc002scd.2	+	5	859	c.611C>T	c.(610-612)TCG>TTG	p.S204L	OTX1_uc010ypt.1_Missense_Mutation_p.S138L	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	204						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					AGCAACACCTCGTGTATGCAG	0.682													0	0	0	0.008291	0	4	4										T	63282997	C	T	63282997	3	4	46	1	0	0	0	0	1	0	0	0	11320	893	31	1	621	1	OTX1	2	63282997	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	833236	63282997	179916376	252	11949										
AFTPH	54812	broad.mit.edu	37	chr2	64796344	64796344	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctccttgggaatagacaccCgaaacattgtgagtttgtta	9	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:64796344C>T	uc002sdc.2	+	3	2238	c.2206C>T	c.(2206-2208)CGA>TGA	p.R736*	AFTPH_uc002scz.2_Nonsense_Mutation_p.R736*|AFTPH_uc002sda.2_Nonsense_Mutation_p.R736*|AFTPH_uc002sdb.2_Nonsense_Mutation_p.R736*	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	736					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						AATAGACACCCGAAACATTGT	0.418													0	0	0	0.012319	0	21	138										T	64796344	C	T	64796344	4	4	46	1	0	0	0	0	0	1	0	0	364	644	23	2	2216	2	AFTPH	2	64796344	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1513347	64796344	178403029	253	11950										
GFPT1	2673	broad.mit.edu	37	chr2	69569358	69569358	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctctggatctcctttatgtGatccttcaaaccacccaaat	4	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:69569358G>C	uc002sfh.2	-	12	1254	c.1075C>G	c.(1075-1077)CAC>GAC	p.H359D		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	377	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						TCCTTTATGTGATCCTTCAAA	0.358													0	0	0	0.01441	0	48	232										C	69569358	G	C	69569358	3	2	46	1	0	0	0	0	1	0	0	0	6345	1290	45	1	1002	1	GFPT1	2	69569358	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4773014	69569358	173630015	254	11951										
PCBP1	5093	broad.mit.edu	37	chr2	70315543	70315543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accacctctagatgcctactCgattcaaggacaacacacca	5	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:70315543C>T	uc002sgf.2	+	1	959	c.668C>T	c.(667-669)TCG>TTG	p.S223L	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	223					nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						GATGCCTACTCGATTCAAGGA	0.607													0	0	0	0.00278	0	23	29										T	70315543	C	T	70315543	3	4	46	1	0	0	0	0	1	0	0	0	11500	893	31	1	670	1	PCBP1	2	70315543	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	746185	70315543	172883830	255	11952										
NAGK	55577	broad.mit.edu	37	chr2	71297643	71297643	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttctgtaggggaggcacacGatccgaggtccttttagtct	13	9	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:71297643G>A	uc002shp.3	+	2	447	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_5'UTR|NAGK_uc002shr.2_5'UTR	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	14					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	GGAGGCACACGATCCGAGGTC	0.527											OREG0014689	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	10	35										A	71297643	G	A	71297643	3	1	46	1	0	0	0	0	1	0	0	0	10142	1058	37	1	185	1	NAGK	2	71297643	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	982100	71297643	171901730	256	11953										
CCDC142	84865	broad.mit.edu	37	chr2	74709391	74709391	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggcccgggctggcgggctCccggccgagagcgcgaagct	18	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:74709391C>T	uc002slr.2	-	1	967	c.574G>A	c.(574-576)GAG>AAG	p.E192K	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.E192K|CCDC142_uc002slp.2_Missense_Mutation_p.E192K	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	192										central_nervous_system(1)	1						CTGGCGGGCTCCCGGCCGAGA	0.667													0	0	0	0.001168	0	6	9										T	74709391	C	T	74709391	3	4	46	1	0	0	0	0	1	0	0	0	2776	864	30	1	1693	1	CCDC142	2	74709391	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3411748	74709391	168489982	257	11954										
SEMA4F	10505	broad.mit.edu	37	chr2	74883774	74883774	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgcccgggacaccatcttcGctttatccctgcccttctca	7	18	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:74883774G>C	uc002sna.1	+	2	370	c.259G>C	c.(259-261)GCT>CCT	p.A87P	SEMA4F_uc010ysb.1_Missense_Mutation_p.A87P|SEMA4F_uc010ffq.1_Missense_Mutation_p.A87P|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.A87P	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	87	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CACCATCTTCGCTTTATCCCT	0.527													0	0	0	0.01441	0	54	80										C	74883774	G	C	74883774	3	2	46	1	0	0	0	0	1	0	0	0	14035	1087	38	4	265	4	SEMA4F	2	74883774	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	174383	74883774	168315599	258	11955										
C2orf89	129293	broad.mit.edu	37	chr2	85108116	85108116	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgccgcgaagctgcgcccgtGggcaggaggcagagggtctg	19	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:85108116G>C	uc010ysl.1	-	1	137	c.48C>G	c.(46-48)CCC>CCG	p.P16P	C2orf89_uc002sou.3_Silent_p.P16P|C2orf89_uc010fgc.1_Silent_p.P16P	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	16						integral to membrane				ovary(1)	1						CTGCGCCCGTGGGCAGGAGGC	0.711													0	0	0	0.004482	0	7	3										C	85108116	G	C	85108116	2	2	46	1	0	0	0	0	0	0	0	1	2203	1335	47	4		4	C2orf89	2	85108116	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10224342	85108116	158091257	259	11956										
ELMOD3	84173	broad.mit.edu	37	chr2	85616934	85616934	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgccatccaggccttgagaGaggagtgtctctccaggtga	13	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:85616934G>A	uc002spf.3	+	13	1464	c.799G>A	c.(799-801)GAG>AAG	p.E267K	ELMOD3_uc002spg.3_Missense_Mutation_p.E267K|ELMOD3_uc002sph.3_Missense_Mutation_p.E267K|ELMOD3_uc010ysn.1_Missense_Mutation_p.E267K|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_RNA	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	267	ELMO.				phagocytosis	cytoskeleton				ovary(2)	2						GGCCTTGAGAGAGGAGTGTCT	0.542													0	0	0	0.003755	0	33	40										A	85616934	G	A	85616934	3	1	46	1	0	0	0	0	1	0	0	0	5070	943	33	1	833	1	ELMOD3	2	85616934	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	508818	85616934	157582439	260	11957										
SH2D6	284948	broad.mit.edu	37	chr2	85662187	85662187	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcaataatctgcttcttctaGaaggaaggaaatcgtctctt	7	8	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:85662187G>A	uc002spq.2	+	1	270	c.109G>A	c.(109-111)GAA>AAA	p.E37K	SH2D6_uc002spo.2_Splice_Site|SH2D6_uc002spp.2_Splice_Site	NM_198482	NP_940884	Q7Z4S9	SH2D6_HUMAN	SH2 domain containing 6	37										central_nervous_system(1)	1						GCTTCTTCTAGAAGGAAGGAA	0.512													0	0	0	0.006214	0	10	23										A	85662187	G	A	85662187	3	1	46	1	0	0	0	0	1	0	0	0	14238	943	33	1	111	1	SH2D6	2	85662187	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	45253	85662187	157537186	261	11958										
POLR1A	25885	broad.mit.edu	37	chr2	86259451	86259451	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcatcggcgtccccctcctCagcttcagcatccacaatgt	8	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:86259451C>T	uc002sqs.2	-	29	4595	c.4216G>A	c.(4216-4218)GAG>AAG	p.E1406K	POLR1A_uc010ytb.1_Missense_Mutation_p.E772K	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1406					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TCCCCCTCCTCAGCTTCAGCA	0.567													0	0	0	0.00623	0	40	54										T	86259451	C	T	86259451	3	4	46	1	0	0	0	0	1	0	0	0	12209	835	29	1	970	1	POLR1A	2	86259451	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	597264	86259451	156939922	262	11959										
PTCD3	55037	broad.mit.edu	37	chr2	86333455	86333455	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcggcgggcgggtttgtgtGaacaggcacgcagctgcagg	19	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:86333455G>A	uc002sqw.2	+	1	151	c.85G>A	c.(85-87)GAA>AAA	p.E29K	POLR1A_uc002sqs.2_5'Flank|POLR1A_uc002sqv.2_5'Flank|PTCD3_uc010ytc.1_RNA	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	29						mitochondrion	protein binding			ovary(1)	1						GGGTTTGTGTGAACAGGCACG	0.597													0	0	0	0.014323	0	17	47										A	86333455	G	A	86333455	3	1	46	1	0	0	0	0	1	0	0	0	12729	1291	45	1	87	1	PTCD3	2	86333455	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	74004	86333455	156865918	263	11960										
KRCC1	51315	broad.mit.edu	37	chr2	88327938	88327938	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtgggtctggaattaacctCtcctttgtacccacaggttt	9	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:88327938C>T	uc002sso.1	-	4	539	c.145G>A	c.(145-147)GAG>AAG	p.E49K	KRCC1_uc002ssp.1_Missense_Mutation_p.E49K	NM_016618	NP_057702	Q9NPI7	KRCC1_HUMAN	lysine-rich coiled-coil 1	49										ovary(1)	1						GAATTAACCTCTCCTTTGTAC	0.418													0	0	0	0.01441	0	52	93										T	88327938	C	T	88327938	3	4	46	1	0	0	0	0	1	0	0	0	8441	922	32	1	638	1	KRCC1	2	88327938	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1994483	88327938	154871435	264	11961										
PROM2	150696	broad.mit.edu	37	chr2	95940393	95940393	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgggcctggggctggccctGagtcagctggctgcaggggc	19	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:95940393G>A	uc002suh.1	+	1	193	c.60G>A	c.(58-60)CTG>CTA	p.L20L	PROM2_uc002sui.2_Silent_p.L20L|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.L20L|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	20						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GGCTGGCCCTGAGTCAGCTGG	0.677													0	0	0	0.008291	0	10	65										A	95940393	G	A	95940393	2	1	46	1	0	0	0	0	0	0	0	1	12556	1277	45	1		1	PROM2	2	95940393	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7612455	95940393	147258980	265	11962										
PROM2	150696	broad.mit.edu	37	chr2	95940456	95940456	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccggcagagcacctgacattCaccccagcagccagggcccg	11	18	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:95940456C>T	uc002suh.1	+	1	256	c.123C>T	c.(121-123)TTC>TTT	p.F41F	PROM2_uc002sui.2_Silent_p.F41F|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.F41F|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	41	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						ACCTGACATTCACCCCAGCAG	0.697													0	0	0	0.013114	0	42	147										T	95940456	C	T	95940456	2	4	46	1	0	0	0	0	0	0	0	1	12556	825	29	1		1	PROM2	2	95940456	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	63	95940456	147258917	266	11963										
FAHD2A	51011	broad.mit.edu	37	chr2	96072879	96072879	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccatcgtggggccctatgatGaggtggtcctcccaccacag	12	14	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:96072879G>T	uc002sur.2	+	3	615	c.436G>T	c.(436-438)GAG>TAG	p.E146*	FAHD2A_uc002sus.2_Nonsense_Mutation_p.E146*	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	146							hydrolase activity|metal ion binding			ovary(1)	1						GCCCTATGATGAGGTGGTCCT	0.562													1	0	9.05144e-12	0.001855	9.45218e-12	10	124										T	96072879	G	T	96072879	4	4	46	1	0	0	0	0	0	1	0	0	5373	1291	45	3	442	3	FAHD2A	2	96072879	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	132423	96072879	147126494	267	11964										
ARID5A	10865	broad.mit.edu	37	chr2	97215120	97215120	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgggaggaggagcaggccttCctggtcagcctctacaagtt	14	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:97215120C>T	uc002swe.2	+	3	283	c.183C>T	c.(181-183)TTC>TTT	p.F61F	ARID5A_uc010yuq.1_5'UTR|ARID5A_uc002swf.2_Intron|ARID5A_uc002swg.2_Intron	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	61	ARID.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						agcaggCCTTCCTGGTCAGCC	0.478													0	0	0	0.008361	0	28	46										T	97215120	C	T	97215120	2	4	46	1	0	0	0	0	0	0	0	1	921	854	30	1		1	ARID5A	2	97215120	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1142241	97215120	145984253	268	11965										
EIF5B	9669	broad.mit.edu	37	chr2	99976974	99976974	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagaattgtctttggaagctCaaggcatcaaagctgacaga	10	7	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:99976974C>G	uc002tab.2	+	3	392	c.208C>G	c.(208-210)CAA>GAA	p.Q70E		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	70					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TTTGGAAGCTCAAGGCATCAA	0.348													0	0	0	0.007413	0	19	44										G	99976974	C	G	99976974	3	3	46	1	0	0	0	0	1	0	0	0	5044	827	29	1	218	1	EIF5B	2	99976974	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2761854	99976974	143222399	269	11966										
EIF5B	9669	broad.mit.edu	37	chr2	99984993	99984993	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagactctttgccaaagaaGaggccaatttatgaagataa	8	6	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:99984993G>A	uc002tab.2	+	7	1510	c.1326G>A	c.(1324-1326)AAG>AAA	p.K442K		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	442					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TGCCAAAGAAGAGGCCAATTT	0.343													0	0	0	0.003755	0	35	63										A	99984993	G	A	99984993	2	1	46	1	0	0	0	0	0	0	0	1	5044	933	33	1		1	EIF5B	2	99984993	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8019	99984993	143214380	270	11967										
TBC1D8	11138	broad.mit.edu	37	chr2	101648738	101648738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtctgtttaccgatcactCggtggttgaagtaatcgggc	14	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:101648738C>T	uc010fiv.2	-	11	2014	c.1883G>A	c.(1882-1884)CGA>CAA	p.R628Q	TBC1D8_uc002tau.3_Missense_Mutation_p.R385Q	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	628	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						ACCGATCACTCGGTGGTTGAA	0.532													0	0	0	0.004482	0	9	12										T	101648738	C	T	101648738	3	4	46	1	0	0	0	0	1	0	0	0	15622	884	31	1	1579	1	TBC1D8	2	101648738	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1663745	101648738	141550635	271	11968										
POU3F3	5455	broad.mit.edu	37	chr2	105473173	105473180	+	Frame_Shift_Del	DEL	CGCAGGGC	CGCAGGGC	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagcatcgacaagatcgcggCgcagggccgcaagcgcaaga					rs140129722		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:105473173_105473180delCGCAGGGC	uc010ywg.1	+	1	1205_1212	c.1205_1212delCGCAGGGC	c.(1204-1212)GCGCAGGGCfs	p.A402fs		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	402_404					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						AAGATCGCGGCGCAGGGCCGCAAGCGCA	0.625																		12	26	---	---								-	105473180	CGCAGGGC	-	105473173	7	5	46	1	0	1	0	1	0	0	0	0	12276	768	27	0	1207	0	POU3F3	2	105473173	Frame_Shift_Del	DEL	CGCAGGGC	TCGA-DK-A1AC-01A-11D-A13W-08	3824435	105473173	137726200	272	11969										
C2orf49	79074	broad.mit.edu	37	chr2	105959589	105959589	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacgcataggaaaagtccttCaggccctgtgaagtcgccac	10	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:105959589C>T	uc002tcs.1	+	3	583	c.551C>T	c.(550-552)TCA>TTA	p.S184L	C2orf49_uc010fjd.1_Missense_Mutation_p.S142L	NM_024093	NP_076998	Q9BVC5	ASHWN_HUMAN	ashwin	184						tRNA-splicing ligase complex					0						AAAAGTCCTTCAGGCCCTGTG	0.443													0	0	0	0.005524	0	40	73										T	105959589	C	T	105959589	3	4	46	1	0	0	0	0	1	0	0	0	2171	838	29	1	561	1	C2orf49	2	105959589	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	486416	105959589	137239784	273	11970										
SLC5A7	60482	broad.mit.edu	37	chr2	108608600	108608600	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtatatcaatggcacagctGaagcagtttatgtaccaggt	11	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:108608600G>A	uc002tdv.2	+	3	493	c.217G>A	c.(217-219)GAA>AAA	p.E73K	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.E73K|SLC5A7_uc010ywn.1_5'UTR	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	73	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TGGCACAGCTGAAGCAGTTTA	0.423													0	0	0	0.003755	0	34	53										A	108608600	G	A	108608600	3	1	46	1	0	0	0	0	1	0	0	0	14670	1291	45	1	223	1	SLC5A7	2	108608600	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2649011	108608600	134590773	274	11971										
RANBP2	5903	broad.mit.edu	37	chr2	109352069	109352069	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagaactttatgtaagacctGatgacgtccatgtgaacatc	8	9	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:109352069G>C	uc002tem.3	+	5	613	c.487G>C	c.(487-489)GAT>CAT	p.D163H		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	163					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGTAAGACCTGATGACGTCCA	0.438													0	0	0	0.01441	0	102	410										C	109352069	G	C	109352069	3	2	46	1	0	0	0	0	1	0	0	0	13028	1290	45	1	505	1	RANBP2	2	109352069	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	743469	109352069	133847304	275	11972										
RANBP2	5903	broad.mit.edu	37	chr2	109383083	109383083	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagaacttgtaacaggagaaGaagatgaaaaagttctgtat	10	3	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:109383083G>A	uc002tem.3	+	20	6214	c.6088G>A	c.(6088-6090)GAA>AAA	p.E2030K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2030	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AACAGGAGAAGAAGATGAAAA	0.388													0	0	0	0.01441	0	134	630										A	109383083	G	A	109383083	3	1	46	1	0	0	0	0	1	0	0	0	13028	943	33	1	6166	1	RANBP2	2	109383083	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	31014	109383083	133816290	276	11973										
SEPT10	151011	broad.mit.edu	37	chr2	110332307	110332307	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcttcttggagataggcctCaaactgagcatctatgtagt	9	8	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:110332307C>T	uc002tew.2	-	5	830	c.451G>A	c.(451-453)GAG>AAG	p.E151K	SEPT10_uc010ywu.1_Intron|SEPT10_uc002tex.2_Missense_Mutation_p.E128K|SEPT10_uc002tey.2_Missense_Mutation_p.E151K|SEPT10_uc010ywv.1_Missense_Mutation_p.E17K|SEPT10_uc002tev.1_5'UTR|SEPT10_uc010fjo.2_RNA	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	151					cell cycle|cell division	septin complex	GTP binding				0						AGATAGGCCTCAAACTGAGCA	0.378													0	0	0	0.01441	0	49	67										T	110332307	C	T	110332307	3	4	46	1	0	0	0	0	1	0	0	0	14060	835	29	1	941	1	SEPT10	2	110332307	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	949224	110332307	132867066	277	11974										
ANAPC1	64682	broad.mit.edu	37	chr2	112550062	112550062	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaaaacctttaggtttcctGagccagccatgaccatggcg	10	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:112550062G>A	uc002thi.2	-	38	4836	c.4589C>T	c.(4588-4590)TCA>TTA	p.S1530L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1530	PC 4.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						TAGGTTTCCTGAGCCAGCCAT	0.483													0	0	0	0.004007	0	12	45										A	112550062	G	A	112550062	3	1	46	1	0	0	0	0	1	0	0	0	598	1294	45	1	1289	1	ANAPC1	2	112550062	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2217755	112550062	130649311	278	11975										
MERTK	10461	broad.mit.edu	37	chr2	112751899	112751899	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttcaagtccacaatgctacGtgcacagtgaggattgcagc	11	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:112751899G>A	uc002thk.1	+	9	1490	c.1368G>A	c.(1366-1368)ACG>ACA	p.T456T	MERTK_uc002thl.1_Silent_p.T280T	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	456	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						ACAATGCTACGTGCACAGTGA	0.522													0	0	0	0.01441	0	71	109										A	112751899	G	A	112751899	2	1	46	1	0	0	0	0	0	0	0	1	9479	1132	40	2		2	MERTK	2	112751899	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	201837	112751899	130447474	279	11976										
FOXD4L1	200350	broad.mit.edu	37	chr2	114256945	114256945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagaggaggaagatgaagacGaggtggaagacgaggaggag	21	2	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:114256945G>A	uc002tjw.3	+	1	285	c.112G>A	c.(112-114)GAG>AAG	p.E38K		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	38					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						agatgaagacgaggtggaaga	0.532													0	0	0	0.01441	0	48	63										A	114256945	G	A	114256945	3	1	46	1	0	0	0	0	1	0	0	0	6000	1059	37	1	114	1	FOXD4L1	2	114256945	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1505046	114256945	128942428	280	11977										
EN1	2019	broad.mit.edu	37	chr2	119604241	119604241	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtccggggcgcacaggagcGaggcagcgcctggcgcccgg	19	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:119604241G>A	uc002tlm.2	-	1	1519	c.503C>T	c.(502-504)TCG>TTG	p.S168L		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	168					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GCACAGGAGCGAGGCAGCGCC	0.602													0	0	0	0.00308	0	8	4										A	119604241	G	A	119604241	3	1	46	1	0	0	0	0	1	0	0	0	5109	1059	37	1	683	1	EN1	2	119604241	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5347296	119604241	123595132	281	11978										
CNTNAP5	129684	broad.mit.edu	37	chr2	125504879	125504879	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggggaggttcccctcctggGgtccagcagtgtgagtgtgg	18	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:125504879G>T	uc002tno.2	+	14	2512	c.2148G>T	c.(2146-2148)GGG>GGT	p.G716G	CNTNAP5_uc010flu.2_Silent_p.G717G	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	716	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCCCTCCTGGGGTCCAGCAGT	0.517													1	0	6.4771e-29	0.010771	6.86965e-29	44	74										T	125504879	G	T	125504879	2	4	46	1	0	0	0	0	0	0	0	1	3650	1219	43	4		4	CNTNAP5	2	125504879	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5900638	125504879	117694494	282	11979										
UGGT1	56886	broad.mit.edu	37	chr2	128867254	128867254	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggatgtaattcgtttttttCagtgcatggaaagaagactt	10	4	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:128867254C>T	uc002tps.2	+	5	633	c.455C>T	c.(454-456)TCA>TTA	p.S152L	UGGT1_uc010fme.1_Missense_Mutation_p.S27L|UGGT1_uc002tpr.2_Missense_Mutation_p.S128L	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	152					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TCGTTTTTTTCAGTGCATGGA	0.378													0	0	0	0.01441	0	51	77										T	128867254	C	T	128867254	3	4	46	1	0	0	0	0	1	0	0	0	16938	838	29	1	473	1	UGGT1	2	128867254	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3362375	128867254	114332119	283	11980										
HS6ST1	9394	broad.mit.edu	37	chr2	129026352	129026352	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccatcacacatatgcaacGacgtcttccacgtggcaccc	7	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:129026352G>A	uc002tpt.3	-	2	654	c.620C>T	c.(619-621)TCG>TTG	p.S207L		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	207	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CATATGCAACGACGTCTTCCA	0.632													0	0	0	0.010729	0	12	58										A	129026352	G	A	129026352	3	1	46	1	0	0	0	0	1	0	0	0	7370	1059	37	1	619	1	HS6ST1	2	129026352	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	159098	129026352	114173021	284	11981										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135888197	135888197	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aattcataaattatcagtttCaaatatggtacacactgcaa	4	7	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:135888197C>T	uc002tuj.2	+	13	1167	c.1142C>T	c.(1141-1143)TCA>TTA	p.S381L	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.S381L|RAB3GAP1_uc010fng.2_Missense_Mutation_p.S206L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	381						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TTATCAGTTTCAAATATGGTA	0.338													0	0	0	0.004007	0	16	51										T	135888197	C	T	135888197	3	4	46	1	0	0	0	0	1	0	0	0	12935	838	29	1	1192	1	RAB3GAP1	2	135888197	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6861845	135888197	107311176	285	11982										
DARS	1615	broad.mit.edu	37	chr2	136743012	136743012	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcccgcggcttctcctgactCttgcggctggcgctggcgct	13	16	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:136743012C>T	uc002tux.1	-	1	211	c.27G>A	c.(25-27)AAG>AAA	p.K9K	DARS_uc010fnj.1_5'UTR	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	9					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	TCTCCTGACTCTTGCGGCTGG	0.687													0	0	0	0.013537	0	5	1										T	136743012	C	T	136743012	2	4	46	1	0	0	0	0	0	0	0	1	4241	912	32	1		1	DARS	2	136743012	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	854815	136743012	106456361	286	11983										
LRP1B	53353	broad.mit.edu	37	chr2	141359032	141359032	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcttacttttgacattcatCcaaggctagcacatgtggat	7	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:141359032C>T	uc002tvj.1	-	42	7948	c.6976G>A	c.(6976-6978)GAT>AAT	p.D2326N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2326	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGACATTCATCCAAGGCTAGC	0.378										TSP Lung(27;0.18)			0	0	0	0.005524	0	38	10										T	141359032	C	T	141359032	3	4	46	1	0	0	0	0	1	0	0	0	8955	855	30	1	7023	1	LRP1B	2	141359032	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4616020	141359032	101840341	287	11984										
MBD5	55777	broad.mit.edu	37	chr2	149226996	149226996	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccacccaggtcaccaaggtCaacaatagggtccccaaggc	9	15	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:149226996C>G	uc002twm.3	+	9	2472	c.1484C>G	c.(1483-1485)TCA>TGA	p.S495*	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Nonsense_Mutation_p.S495*|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	495						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCACCAAGGTCAACAATAGGG	0.478													0	0	0	0.00499	0	18	36										G	149226996	C	G	149226996	4	3	46	1	0	0	0	0	0	1	0	0	9347	838	29	1	1498	1	MBD5	2	149226996	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7867964	149226996	93972377	288	11985										
STAM2	10254	broad.mit.edu	37	chr2	153000393	153000393	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttaaaggtgagttcattgtCctcaacagcttcaaaatcat	6	8	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:153000393C>G	uc002tyc.3	-	7	1002	c.652G>C	c.(652-654)GAC>CAC	p.D218H	STAM2_uc010foa.1_Missense_Mutation_p.D218H|STAM2_uc002tyd.2_Missense_Mutation_p.D218H	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	218	SH3.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		AGTTCATTGTCCTCAACAGCT	0.318													0	0	0	0.008871	0	19	37										G	153000393	C	G	153000393	3	3	46	1	0	0	0	0	1	0	0	0	15248	855	30	1	957	1	STAM2	2	153000393	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3773397	153000393	90198980	289	11986										
LRP2	4036	broad.mit.edu	37	chr2	170148823	170148823	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccatcacaaacccagttttGataaatgcatcggccactgg	7	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:170148823G>A	uc002ues.2	-	7	922	c.709C>T	c.(709-711)CAA>TAA	p.Q237*	LRP2_uc010zdf.1_Nonsense_Mutation_p.Q237*	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	237	LDL-receptor class A 6.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCCAGTTTTGATAAATGCAT	0.453													0	0	0	0.00499	0	18	49										A	170148823	G	A	170148823	4	1	46	1	0	0	0	0	0	1	0	0	8956	1299	45	1	13550	1	LRP2	2	170148823	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	17148430	170148823	73050550	290	11987										
TLK1	9874	broad.mit.edu	37	chr2	171913057	171913057	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtatgcctcttactggacttGagccatttccaccctggtac	8	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:171913057G>C	uc002ugn.2	-	6	945	c.473C>G	c.(472-474)TCA>TGA	p.S158*	TLK1_uc002ugo.2_Nonsense_Mutation_p.S179*|TLK1_uc002ugp.2_Nonsense_Mutation_p.S110*|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Nonsense_Mutation_p.S62*|TLK1_uc002ugr.1_5'Flank	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	158					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TACTGGACTTGAGCCATTTCC	0.373													0	0	0	0.00632	0	25	54										C	171913057	G	C	171913057	4	2	46	1	0	0	0	0	0	1	0	0	15940	1294	45	1	1891	1	TLK1	2	171913057	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1764234	171913057	71286316	291	11988										
MAP1D	254042	broad.mit.edu	37	chr2	172928454	172928454	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcaagcacataaagaagccaGactatgtgacgacaggcatt	9	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:172928454G>C	uc002uhk.2	+	3	287	c.214G>C	c.(214-216)GAC>CAC	p.D72H	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	72					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AAAGAAGCCAGACTATGTGAC	0.468													0	0	0	0.009096	0	3	24										C	172928454	G	C	172928454	3	2	46	1	0	0	0	0	1	0	0	0	9229	942	33	1	224	1	MAP1D	2	172928454	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1015397	172928454	70270919	292	11989										
TTN	7273	broad.mit.edu	37	chr2	179604684	179604684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgtttacagcctcgacctCcaccttttcaatatttctta	4	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:179604684C>T	uc010zfh.1	-	46	12987	c.12763G>A	c.(12763-12765)GAG>AAG	p.E4255K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4188K|TTN_uc010zfj.1_Missense_Mutation_p.E4063K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCTCGACCTCCACCTTTTCA	0.458													0	0	0	0.008361	0	31	67										T	179604684	C	T	179604684	3	4	46	1	0	0	0	0	1	0	0	0	16732	864	30	1	91513	1	TTN	2	179604684	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6676230	179604684	63594689	293	11990										
TTN	7273	broad.mit.edu	37	chr2	179606140	179606140	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attggttttaactccttaagGaagtgaggaggacaaggacc	12	6	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:179606140G>C	uc010zfh.1	-	46	11531	c.11307C>G	c.(11305-11307)TTC>TTG	p.F3769L	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.F3702L|TTN_uc010zfj.1_Missense_Mutation_p.F3577L|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCTTAAGGAAGTGAGGAG	0.458													0	0	0	0.01441	0	61	126										C	179606140	G	C	179606140	3	2	46	1	0	0	0	0	1	0	0	0	16732	1165	41	1	92969	1	TTN	2	179606140	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1456	179606140	63593233	294	11991										
TTN	7273	broad.mit.edu	37	chr2	179641337	179641337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccaaattcattgatcatacGgagcctgttggctgcttcaa	8	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:179641337G>A	uc010zfg.1	-	28	5478	c.5254C>T	c.(5254-5256)CGT>TGT	p.R1752C	TTN_uc010zfh.1_Missense_Mutation_p.R1706C|TTN_uc010zfi.1_Missense_Mutation_p.R1706C|TTN_uc010zfj.1_Missense_Mutation_p.R1706C|TTN_uc002unb.2_Missense_Mutation_p.R1752C|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1752							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATCATACGGAGCCTGTTG	0.483													0	0	0	0.00278	0	25	41										A	179641337	G	A	179641337	3	1	46	1	0	0	0	0	1	0	0	0	16732	1116	39	2	106074	2	TTN	2	179641337	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	35197	179641337	63558036	295	11992										
SSFA2	6744	broad.mit.edu	37	chr2	182766801	182766801	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagtggcaataaaaacgatCaaaagtctcaaaaaattatg	6	5	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:182766801C>T	uc002uoi.2	+	8	1343	c.1021C>T	c.(1021-1023)CAA>TAA	p.Q341*	SSFA2_uc002uoh.2_Nonsense_Mutation_p.Q341*|SSFA2_uc002uoj.2_Nonsense_Mutation_p.Q341*|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Nonsense_Mutation_p.Q188*|SSFA2_uc002uol.2_Nonsense_Mutation_p.Q188*	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	341						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TAAAAACGATCAAAAGTCTCA	0.358													0	0	0	0.003163	0	14	43										T	182766801	C	T	182766801	4	4	46	1	0	0	0	0	0	1	0	0	15182	827	29	1	1051	1	SSFA2	2	182766801	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3125464	182766801	60432572	296	11993										
OSGEPL1	64172	broad.mit.edu	37	chr2	190619038	190619038	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accactcatggtggagcactCtggatgttttattaaagaaa	9	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:190619038C>T	uc002uqz.1	-	4	1177	c.643G>A	c.(643-645)GAG>AAG	p.E215K	OSGEPL1_uc002ura.1_RNA	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	215					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			GTGGAGCACTCTGGATGTTTT	0.348													0	0	0	0.00308	0	8	27										T	190619038	C	T	190619038	3	4	46	1	0	0	0	0	1	0	0	0	11288	922	32	1	621	1	OSGEPL1	2	190619038	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7852237	190619038	52580335	297	11994										
GLS	2744	broad.mit.edu	37	chr2	191792056	191792056	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctccattgaagtgacttgtGaatcagccagtgtgatggct	12	8	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:191792056G>A	uc002usf.2	+	12	1537	c.1273G>A	c.(1273-1275)GAA>AAA	p.E425K	GLS_uc002use.2_Missense_Mutation_p.E425K|GLS_uc002usg.1_Missense_Mutation_p.E86K|GLS_uc002ush.2_Missense_Mutation_p.E86K|GLS_uc010zgi.1_5'UTR|GLS_uc010zgj.1_5'Flank	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	425					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGTGACTTGTGAATCAGCCAG	0.383													0	0	0	0.00499	0	13	28										A	191792056	G	A	191792056	3	1	46	1	0	0	0	0	1	0	0	0	6463	1291	45	1	1319	1	GLS	2	191792056	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1173018	191792056	51407317	298	11995										
PLCL1	5334	broad.mit.edu	37	chr2	198950660	198950660	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgatgactacattggggatGagtttatagggcaatatacg	12	4	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:198950660G>A	uc010fsp.2	+	2	2710	c.2419G>A	c.(2419-2421)GAG>AAG	p.E807K	PLCL1_uc002uuv.3_Missense_Mutation_p.E728K	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	807	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CATTGGGGATGAGTTTATAGG	0.423													0	0	0	0.003755	0	38	75										A	198950660	G	A	198950660	3	1	46	1	0	0	0	0	1	0	0	0	12039	1291	45	1	2425	1	PLCL1	2	198950660	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7158604	198950660	44248713	299	11996										
SPATS2L	26010	broad.mit.edu	37	chr2	201342726	201342726	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacagatgcagcagttctctCagtcccggctgtgacgttgg	12	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:201342726C>G	uc002uvn.3	+	13	2001	c.1649C>G	c.(1648-1650)TCA>TGA	p.S550*	SPATS2L_uc010fst.2_Nonsense_Mutation_p.S550*|SPATS2L_uc002uvo.3_Nonsense_Mutation_p.S490*|SPATS2L_uc002uvp.3_Nonsense_Mutation_p.S550*|SPATS2L_uc002uvq.3_Nonsense_Mutation_p.S481*|SPATS2L_uc002uvr.3_Nonsense_Mutation_p.S550*|SPATS2L_uc010zhc.1_Nonsense_Mutation_p.S580*	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	550						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						GCAGTTCTCTCAGTCCCGGCT	0.562													0	0	0	0.008291	0	11	15										G	201342726	C	G	201342726	4	3	46	1	0	0	0	0	0	1	0	0	15019	838	29	1	1691	1	SPATS2L	2	201342726	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2392066	201342726	41856647	300	11997										
ALS2CR4	65062	broad.mit.edu	37	chr2	202494121	202494121	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcacagccagccaagaatCcatgagaaaagagaccaatc	8	12	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:202494121C>G	uc002uyh.1	-	10	802	c.701G>C	c.(700-702)GGA>GCA	p.G234A	ALS2CR4_uc002uyg.1_Missense_Mutation_p.G226A|ALS2CR4_uc010zho.1_Missense_Mutation_p.G29A|ALS2CR4_uc010zhp.1_RNA	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	258	Helical; (Potential).					integral to membrane	protein binding				0						AGCCAAGAATCCATGAGAAAA	0.358													0	0	0	0.001168	0	6	4										G	202494121	C	G	202494121	3	3	46	1	0	0	0	0	1	0	0	0	554	855	30	1	545	1	ALS2CR4	2	202494121	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1151395	202494121	40705252	301	11998										
NBEAL1	65065	broad.mit.edu	37	chr2	204055050	204055050	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgccttaacagatgagaaaGaaagaaaagccttagaaggg	11	5	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:204055050G>C	uc002uzt.3	+	45	7105	c.6772G>C	c.(6772-6774)GAA>CAA	p.E2258Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E968Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2258	BEACH.						binding			ovary(1)|skin(1)	2						AGATGAGAAAGAAAGAAAAGC	0.353													0	0	0	0.003755	0	34	83										C	204055050	G	C	204055050	3	2	46	1	0	0	0	0	1	0	0	0	10188	943	33	1	6946	1	NBEAL1	2	204055050	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1560929	204055050	39144323	302	11999										
PLEKHM3	389072	broad.mit.edu	37	chr2	208725884	208725884	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctccattgttacagatttCacagatgaaccccttctggc	6	13	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:208725884C>T	uc002vcl.2	-	7	2543	c.2053G>A	c.(2053-2055)GAA>AAA	p.E685K		NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	685	Phorbol-ester/DAG-type.				intracellular signal transduction		metal ion binding			ovary(1)	1						TTACAGATTTCACAGATGAAC	0.408													0	0	0	0.01441	0	88	41										T	208725884	C	T	208725884	3	4	46	1	0	0	0	0	1	0	0	0	12082	835	29	1	240	1	PLEKHM3	2	208725884	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4670834	208725884	34473489	303	12000										
PIKFYVE	200576	broad.mit.edu	37	chr2	209190606	209190606	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctctacaggatgacactgGattatatgttactgaggaag	10	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:209190606G>A	uc002vcz.2	+	20	3229	c.3071G>A	c.(3070-3072)GGA>GAA	p.G1024E	PIKFYVE_uc010fun.1_Missense_Mutation_p.G705E|PIKFYVE_uc002vcy.1_Missense_Mutation_p.G968E	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1024					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GATGACACTGGATTATATGTT	0.443													0	0	0	0.01441	0	50	15										A	209190606	G	A	209190606	3	1	46	1	0	0	0	0	1	0	0	0	11924	1174	41	1	3156	1	PIKFYVE	2	209190606	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	464722	209190606	34008767	304	12001										
PIKFYVE	200576	broad.mit.edu	37	chr2	209190762	209190762	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaaaaggggatgagatgctCtacccgagattattttgcag	12	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:209190762C>G	uc002vcz.2	+	20	3385	c.3227C>G	c.(3226-3228)TCT>TGT	p.S1076C	PIKFYVE_uc010fun.1_Missense_Mutation_p.S757C|PIKFYVE_uc002vcy.1_Missense_Mutation_p.S1020C	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1076					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						ATGAGATGCTCTACCCGAGAT	0.423													0	0	0	0.00632	0	27	50										G	209190762	C	G	209190762	3	3	46	1	0	0	0	0	1	0	0	0	11924	913	32	1	3312	1	PIKFYVE	2	209190762	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	156	209190762	34008611	305	12002										
SPAG16	79582	broad.mit.edu	37	chr2	214174842	214174842	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagtaatagaagactttctCtgcaatttcttgatcaaaat	6	6	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:214174842C>T	uc002veq.2	+	4	431	c.339C>T	c.(337-339)CTC>CTT	p.L113L	SPAG16_uc010fuz.1_Intron|SPAG16_uc002ver.2_Silent_p.L59L|SPAG16_uc010zjk.1_Intron|SPAG16_uc002veo.2_Silent_p.L113L|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Silent_p.L82L	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	113					cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AAGACTTTCTCTGCAATTTCT	0.318													0	0	0	0.00632	0	27	57										T	214174842	C	T	214174842	2	4	46	1	0	0	0	0	0	0	0	1	14978	900	32	1		1	SPAG16	2	214174842	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4984080	214174842	29024531	306	12003										
ABCA12	26154	broad.mit.edu	37	chr2	215813432	215813432	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggacagtagccaactaatGagctgtgagaatcaacgtga	12	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:215813432G>A	uc002vew.2	-	47	7212	c.6992C>T	c.(6991-6993)TCA>TTA	p.S2331L	ABCA12_uc002vev.2_Missense_Mutation_p.S2013L|ABCA12_uc010zjn.1_Missense_Mutation_p.S1258L	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2331	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GCCAACTAATGAGCTGTGAGA	0.418													0	0	0	0.013726	0	32	63										A	215813432	G	A	215813432	3	1	46	1	0	0	0	0	1	0	0	0	30	1294	45	1	823	1	ABCA12	2	215813432	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1638590	215813432	27385941	307	12004										
ABCA12	26154	broad.mit.edu	37	chr2	215852376	215852376	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accgacttgtcttactggcaGatgggttggtgttctgcatc	12	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:215852376G>A	uc002vew.2	-	27	4191	c.3971C>T	c.(3970-3972)TCT>TTT	p.S1324F	ABCA12_uc002vev.2_Missense_Mutation_p.S1006F|ABCA12_uc010zjn.1_Missense_Mutation_p.S251F	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1324					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTTACTGGCAGATGGGTTGGT	0.408													0	0	0	0.005443	0	22	38										A	215852376	G	A	215852376	3	1	46	1	0	0	0	0	1	0	0	0	30	942	33	1	3924	1	ABCA12	2	215852376	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	38944	215852376	27346997	308	12005										
ATIC	471	broad.mit.edu	37	chr2	216200791	216200791	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taattgccccaggatatgaaGaagaagccttgacaatactt	8	8	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:216200791G>A	uc002vex.3	+	11	1216	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	ATIC_uc010zjo.1_Missense_Mutation_p.E289K|ATIC_uc002vey.3_Missense_Mutation_p.E347K	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	348					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	AGGATATGAAGAAGAAGCCTT	0.308			T	ALK	ALCL								0	0	0	0.01441	0	64	91										A	216200791	G	A	216200791	3	1	46	1	0	0	0	0	1	0	0	0	1105	943	33	1	1084	1	ATIC	2	216200791	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	348415	216200791	26998582	309	12006										
TTLL4	9654	broad.mit.edu	37	chr2	219602555	219602555	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcagcaagtgaagccaatCtggaagctggaaaagaagca	11	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:219602555C>T	uc002viy.2	+	3	526	c.156C>T	c.(154-156)ATC>ATT	p.I52I	TTLL4_uc010zkl.1_Intron|TTLL4_uc010fvx.2_Silent_p.I52I	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	52					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TGAAGCCAATCTGGAAGCTGG	0.592													0	0	0	0.007291	0	30	99										T	219602555	C	T	219602555	2	4	46	1	0	0	0	0	0	0	0	1	16726	903	32	1		1	TTLL4	2	219602555	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3401764	219602555	23596818	310	12007										
ATG9A	79065	broad.mit.edu	37	chr2	220085580	220085580	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctccaagaggcagccgagaGaaatgagagggaaccctggg	15	10	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:220085580G>A	uc002vke.1	-	15	2589	c.2403C>T	c.(2401-2403)TTC>TTT	p.F801F	ABCB6_uc002vkc.1_5'Flank|ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Silent_p.F801F	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	801	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGCCGAGAGAAATGAGAGG	0.582													0	0	0	0.00499	0	15	49										A	220085580	G	A	220085580	2	1	46	1	0	0	0	0	0	0	0	1	1102	933	33	1		1	ATG9A	2	220085580	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	483025	220085580	23113793	311	12008										
SPEG	10290	broad.mit.edu	37	chr2	220309694	220309694	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtggcacccgccgcctccCgggcagcccaaggcaagcac	14	18	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:220309694C>T	uc010fwg.2	+	3	626	c.626C>T	c.(625-627)CCG>CTG	p.P209L	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	209					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGCCGCCTCCCGGGCAGCCCA	0.716													0	0	0	0.001168	0	5	12										T	220309694	C	T	220309694	3	4	46	1	0	0	0	0	1	0	0	0	15035	652	23	2	636	2	SPEG	2	220309694	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	224114	220309694	22889679	312	12009										
SLC4A3	6508	broad.mit.edu	37	chr2	220494009	220494009	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaacctctgctcctccctccGaggggacccctcccatccag	7	20	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:220494009G>A	uc002vmp.3	+	4	630	c.361G>A	c.(361-363)GAG>AAG	p.E121K	SLC4A3_uc002vmn.2_Missense_Mutation_p.E121K|SLC4A3_uc002vmo.3_Missense_Mutation_p.E121K|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'Flank	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	121	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCTCCCTCCGAGGGGACCCC	0.547													0	0	0	0.013537	0	13	18										A	220494009	G	A	220494009	3	1	46	1	0	0	0	0	1	0	0	0	14655	1059	37	1	371	1	SLC4A3	2	220494009	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	184315	220494009	22705364	313	12010										
PAX3	5077	broad.mit.edu	37	chr2	223096999	223096999	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcatctgattggggtgctGaggctaaaagcacagaagaa	12	7	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:223096999G>A	uc010fwo.2	-	5	956	c.590C>T	c.(589-591)TCA>TTA	p.S197L	PAX3_uc002vmt.1_Missense_Mutation_p.S197L|PAX3_uc002vmy.1_Missense_Mutation_p.S196L|PAX3_uc002vmv.1_Missense_Mutation_p.S197L|PAX3_uc002vmw.1_Missense_Mutation_p.S197L|PAX3_uc002vmx.1_Missense_Mutation_p.S197L	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	197					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGGGGTGCTGAGGCTAAAAG	0.328			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						0	0	0	0.007413	0	20	118										A	223096999	G	A	223096999	3	1	46	1	0	0	0	0	1	0	0	0	11480	1294	45	1	979	1	PAX3	2	223096999	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2602990	223096999	20102374	314	12011										
IRS1	3667	broad.mit.edu	37	chr2	227662785	227662785	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacggcagaacggcccacctCgatgaagaagaagttttccg	11	12	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:227662785C>T	uc002voh.3	-	1	722	c.670G>A	c.(670-672)GAG>AAG	p.E224K		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	224	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CGGCCCACCTCGATGAAGAAG	0.607											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	27										T	227662785	C	T	227662785	3	4	46	1	0	0	0	0	1	0	0	0	7840	893	31	1	3062	1	IRS1	2	227662785	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4565786	227662785	15536588	315	12012										
UGT1A1	54658	broad.mit.edu	37	chr2	234669682	234669682	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtccaggacctattgagctCtgcatctgtctggctgttta	10	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:234669682C>G	uc002vvb.2	+	1	764	c.749C>G	c.(748-750)TCT>TGT	p.S250C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Missense_Mutation_p.S250C	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	250					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CTATTGAGCTCTGCATCTGTC	0.468													0	0	0	0.009535	0	29	66										G	234669682	C	G	234669682	3	3	46	1	0	0	0	0	1	0	0	0	16941	913	32	1	751	1	UGT1A1	2	234669682	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7006897	234669682	8529691	316	12013										
ANO7	50636	broad.mit.edu	37	chr2	242135138	242135138	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagacttcgtcctcgtttggGaggaggacctgaagctagac	13	10	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:242135138G>T	uc002wax.2	+	4	452	c.349G>T	c.(349-351)GAG>TAG	p.E117*	ANO7_uc002waw.2_Nonsense_Mutation_p.E116*	NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	117	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCTCGTTTGGGAGGAGGACCT	0.617													1	0	4.36969e-10	0.001855	4.54565e-10	12	8										T	242135138	G	T	242135138	4	4	46	1	0	0	0	0	0	1	0	0	702	1175	41	3	363	3	ANO7	2	242135138	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7465456	242135138	1064235	317	12014										
ANO7	50636	broad.mit.edu	37	chr2	242162689	242162689	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggccttcgtcattgtgtttGaggtagccgaggcacctgct	13	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:242162689G>A	uc002wax.2	+	22	2675	c.2572G>A	c.(2572-2574)GAG>AAG	p.E858K		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	858	Helical; (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CATTGTGTTTGAGGTAGCCGA	0.577													0	0	0	0.01441	0	47	14										A	242162689	G	A	242162689	3	1	46	1	0	0	0	0	1	0	0	0	702	1291	45	1	2730	1	ANO7	2	242162689	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	27551	242162689	1036684	318	12015										
ANO7	50636	broad.mit.edu	37	chr2	242163167	242163167	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagtgaagcgggagtactacCtggctaagcaggcactggct	14	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:242163167C>T	uc002wax.2	+	23	2768	c.2665C>T	c.(2665-2667)CTG>TTG	p.L889L		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	889	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GGAGTACTACCTGGCTAAGCA	0.592													0	0	0	0.001855	0	13	21										T	242163167	C	T	242163167	2	4	46	1	0	0	0	0	0	0	0	1	702	680	24	2		2	ANO7	2	242163167	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	478	242163167	1036206	319	12016										
BHLHE40	8553	broad.mit.edu	37	chr3	5022016	5022016	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aattgccgcaccggctcatcGagaaaaagagacgtgaccgg	12	11	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:5022016G>A	uc003bqf.2	+	3	488	c.181G>A	c.(181-183)GAG>AAG	p.E61K	uc003bqe.1_5'Flank|uc010hce.1_5'Flank|BHLHE40_uc011asw.1_5'UTR	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	61	Basic motif.					Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCGGCTCATCGAGAAAAAGAG	0.567											OREG0015367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00874	0	38	7										A	5022016	G	A	5022016	3	1	46	1	0	0	0	0	1	0	0	0	1423	1059	37	1	191	1	BHLHE40	3	5022016	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		5022016	193000414	320	12017										
SRGAP3	9901	broad.mit.edu	37	chr3	9055453	9055453	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgaagaggtatctcatgacCacaatgaccacgcggggaag	13	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9055453C>G	uc003brf.1	-	16	2563	c.1887G>C	c.(1885-1887)GTG>GTC	p.V629V	SRGAP3_uc003brg.1_Silent_p.V605V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	629	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		ATCTCATGACCACAATGACCA	0.552			T	RAF1	pilocytic astrocytoma								0	0	0	0.004482	0	6	111										G	9055453	C	G	9055453	2	3	46	1	0	0	0	0	0	0	0	1	15146	581	21	4		4	SRGAP3	3	9055453	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4033437	9055453	188966977	321	12018										
CAMK1	8536	broad.mit.edu	37	chr3	9803376	9803376	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccgggtcctccatcttggaGaggccaaagtcggagatcat	12	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9803376G>A	uc003bst.2	-	6	673	c.495C>T	c.(493-495)CTC>CTT	p.L165L	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_5'Flank|uc003bsv.1_RNA	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	165	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CCATCTTGGAGAGGCCAAAGT	0.602													0	0	0	0.00623	0	40	86										A	9803376	G	A	9803376	2	1	46	1	0	0	0	0	0	0	0	1	2596	929	33	1		1	CAMK1	3	9803376	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	747923	9803376	188219054	322	12019										
IL17RC	84818	broad.mit.edu	37	chr3	9959040	9959040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgtccttggcactgggccGaagcccagtggtcctttctc	12	14	1	0	rs112532783	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9959040G>A	uc003bua.2	+	1	277	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_RNA|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Missense_Mutation_p.R14Q|IL17RC_uc003btz.2_Missense_Mutation_p.R14Q|IL17RC_uc011atp.1_5'UTR|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Missense_Mutation_p.R14Q|IL17RC_uc010hct.2_Missense_Mutation_p.R14Q|IL17RC_uc010hcu.2_Missense_Mutation_p.R14Q|IL17RC_uc010hcv.2_Missense_Mutation_p.R14Q|IL17RC_uc011atq.1_Missense_Mutation_p.R14Q|IL17RC_uc003buc.2_5'UTR	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	14						integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GCACTGGGCCGAAGCCCAGTG	0.657													0	0	0	0.00499	0	12	70										A	9959040	G	A	9959040	3	1	46	1	0	0	0	0	1	0	0	0	7641	1058	37	1	43	1	IL17RC	3	9959040	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	155664	9959040	188063390	323	12020										
CRELD1	78987	broad.mit.edu	37	chr3	9986069	9986069	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtcagcaggcttcttctcaGagatgacagaagacgagttg	12	8	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9986069G>A	uc003bug.2	+	11	1187	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Silent_p.Q421Q|CRELD1_uc003buh.2_Missense_Mutation_p.E357K|CRELD1_uc003bui.2_Missense_Mutation_p.E357K|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	357	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						CTTCTTCTCAGAGATGACAGA	0.547													0	0	0	0.006999	0	38	288										A	9986069	G	A	9986069	3	1	46	1	0	0	0	0	1	0	0	0	3866	943	33	1	1305	1	CRELD1	3	9986069	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	27029	9986069	188036361	324	12021										
PRRT3	285368	broad.mit.edu	37	chr3	9988960	9988960	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagccgagggcccgggctggCatcccagccccgtgggccgt	16	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9988960C>T	uc003bul.2	-	4	2027	c.1897G>A	c.(1897-1899)GCC>ACC	p.A633T	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	633	Cytoplasmic (Potential).					integral to membrane					0						CCCGGGCTGGCATCCCAGCCC	0.766													0	0	0	0.001984	0	6	0										T	9988960	C	T	9988960	3	4	46	1	0	0	0	0	1	0	0	0	12611	710	25	2	1052	2	PRRT3	3	9988960	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2891	9988960	188033470	325	12022										
FANCD2	2177	broad.mit.edu	37	chr3	10070355	10070355	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtcaaaatggtttccaaaaGaagactgtcaaaatctgagg	10	6	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:10070355G>C	uc003buw.2	+	2	92	c.14G>C	c.(13-15)AGA>ACA	p.R5T	CIDEC_uc003bto.2_5'Flank|FANCD2_uc003bux.1_Missense_Mutation_p.R5T|FANCD2_uc003buy.1_Missense_Mutation_p.R5T|CIDECP_uc003bus.2_5'Flank|CIDECP_uc003but.2_5'Flank|CIDECP_uc003buu.1_5'Flank|FANCD2_uc003buv.2_Missense_Mutation_p.R5T	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	5	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GTTTCCAAAAGAAGACTGTCA	0.388			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.001984	0	7	105										C	10070355	G	C	10070355	3	2	46	1	0	0	0	0	1	0	0	0	5665	942	33	1	16	1	FANCD2	3	10070355	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	81395	10070355	187952075	326	12023										
FANCD2	2177	broad.mit.edu	37	chr3	10127604	10127604	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcctttggaggaactactCaggtgagtcataactacata	9	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:10127604C>T	uc003buw.2	+	33	3411	c.3333C>T	c.(3331-3333)CTC>CTT	p.L1111L	FANCD2_uc003bux.1_Silent_p.L1111L|FANCD2_uc003buy.1_Silent_p.L1111L|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1111					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGGAACTACTCAGGTGAGTCA	0.428			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	179	27										T	10127604	C	T	10127604	2	4	46	1	0	0	0	0	0	0	0	1	5665	813	29	1		1	FANCD2	3	10127604	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	57249	10127604	187894826	327	12024										
IQSEC1	9922	broad.mit.edu	37	chr3	12950806	12950806	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttctccatctcttggacttCcgcaatggactcccgcaggt	8	15	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:12950806C>T	uc003bxt.2	-	11	2596	c.2587G>A	c.(2587-2589)GAA>AAA	p.E863K	IQSEC1_uc003bxu.3_Missense_Mutation_p.E741K|IQSEC1_uc011auw.1_Missense_Mutation_p.E849K	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	863	PH.|Potential.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						TCTTGGACTTCCGCAATGGAC	0.537													0	0	0	0.01441	0	68	174										T	12950806	C	T	12950806	3	4	46	1	0	0	0	0	1	0	0	0	7817	864	30	1	865	1	IQSEC1	3	12950806	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2823202	12950806	185071624	328	12025										
FGD5	152273	broad.mit.edu	37	chr3	14949214	14949214	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggggatctcctccagccagGaagggtgagtgccgccacca	14	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:14949214G>T	uc003bzc.2	+	10	3442	c.3332G>T	c.(3331-3333)GGA>GTA	p.G1111V	FGD5_uc011avk.1_Missense_Mutation_p.G1111V|FGD5_uc003bzd.2_Missense_Mutation_p.G189V	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1111					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CTCCAGCCAGGAAGGGTGAGT	0.642													1	0	1.12685e-05	0.004482	1.1518e-05	4	22										T	14949214	G	T	14949214	3	4	46	1	0	0	0	0	1	0	0	0	5836	1174	41	3	3370	3	FGD5	3	14949214	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1998408	14949214	183073216	329	12026										
STAC	6769	broad.mit.edu	37	chr3	36570456	36570456	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtgtaaggaacaggggcaGataacactgaaagagaatca	14	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:36570456G>C	uc003cgh.1	+	10	1128	c.1089G>C	c.(1087-1089)CAG>CAC	p.Q363H	STAC_uc011aya.1_Missense_Mutation_p.Q302H	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	363					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						AACAGGGGCAGATAACACTGA	0.343													0	0	0	0.003954	0	24	24										C	36570456	G	C	36570456	3	2	46	1	0	0	0	0	1	0	0	0	15238	933	33	1	1127	1	STAC	3	36570456	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	21621242	36570456	161451974	330	12027										
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033664	37033664	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taatcaaaactatccattcgGatatggtatttatgatctga	6	6	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:37033664G>A	uc003cgk.2	-	1	1132	c.905C>T	c.(904-906)TCC>TTC	p.S302F	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	302						endoplasmic reticulum					0						TATCCATTCGGATATGGTATT	0.393													0	0	0	0.008871	0	20	82										A	37033664	G	A	37033664	3	1	46	1	0	0	0	0	1	0	0	0	5184	1174	41	1	922	1	EPM2AIP1	3	37033664	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	463208	37033664	160988766	331	12028										
XYLB	9942	broad.mit.edu	37	chr3	38415956	38415956	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcccctcccattctcagcgtCgctggcaggcatgagactgg	11	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:38415956C>T	uc003cic.2	+	11	960	c.851C>T	c.(850-852)TCG>TTG	p.S284L	XYLB_uc011ayp.1_Missense_Mutation_p.S147L|XYLB_uc003cid.1_Missense_Mutation_p.S206L	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	284					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TTCTCAGCGTCGCTGGCAGGC	0.587													0	0	0	0.003271	0	23	16										T	38415956	C	T	38415956	3	4	46	1	0	0	0	0	1	0	0	0	17459	893	31	1	893	1	XYLB	3	38415956	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1382292	38415956	159606474	332	12029										
CX3CR1	1524	broad.mit.edu	37	chr3	39307491	39307491	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaaggcattcattttctttCtgctttgtgaacatgaactg	7	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:39307491C>G	uc003cjl.2	-	2	602	c.510G>C	c.(508-510)CAG>CAC	p.Q170H		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	170	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CATTTTCTTTCTGCTTTGTGA	0.547													0	0	0	0.00874	0	41	91										G	39307491	C	G	39307491	3	3	46	1	0	0	0	0	1	0	0	0	4075	912	32	1	561	1	CX3CR1	3	39307491	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	891535	39307491	158714939	333	12030										
ENTPD3	956	broad.mit.edu	37	chr3	40456182	40456182	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttgtacaggttgcaaaatGaaacagcagctaatgaagtc	9	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:40456182G>A	uc003ckd.3	+	6	540	c.448G>A	c.(448-450)GAA>AAA	p.E150K	ENTPD3_uc010hhy.2_Missense_Mutation_p.E150K|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	150	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GTTGCAAAATGAAACAGCAGC	0.423													0	0	0	0.01441	0	55	53										A	40456182	G	A	40456182	3	1	46	1	0	0	0	0	1	0	0	0	5140	1291	45	1	466	1	ENTPD3	3	40456182	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1148691	40456182	157566248	334	12031										
CTNNB1	1499	broad.mit.edu	37	chr3	41266101	41266101	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaacagtcttacctggactCtggaatccattctggtgcca	9	12	3	0	rs121913400		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:41266101C>T	uc010hia.1	+	4	254	c.98C>T	c.(97-99)TCT>TTT	p.S33F	CTNNB1_uc003ckp.2_Missense_Mutation_p.S33F|CTNNB1_uc003ckq.2_Missense_Mutation_p.S33F|CTNNB1_uc003ckr.2_Missense_Mutation_p.S33F|CTNNB1_uc011azf.1_Missense_Mutation_p.S26F|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	33			S -> F (in PTR, MDB and hepatocellular carcinoma).|Missing (in hepatocellular carcinoma).|S -> Y (in colorectal cancer and PTR; enhances transactivation of target genes).|S -> L (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S33C(131)|p.S33F(79)|p.A5_A80del(63)|p.S33Y(52)|p.S33P(37)|p.S33A(14)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.S33L(4)|p.W25_I140del(4)|p.S33N(3)|p.S23_S33del(3)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.W25_H36del(2)|p.Y30_S33del(2)|p.V22_S33del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.S33T(1)|p.S33S(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S29_H36del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.W25_I35del(1)|p.V22_G80>NNNNN(1)|p.A5_I35del(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.W25_S33del(1)|p.V22_T102del(1)|p.S33_G34del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.D32_H36>D(1)|p.S33_G34insGTS(1)|p.P16_K133del(1)|p.A5_T59del(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.W25_A80del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.D32_S33insS(1)|p.S33_G34insS(1)|p.Y30_T40del(1)|p.S33_G34insGI(1)|p.M1_T42del(1)|p.A5_Q143>E(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.S23_I35del(1)|p.V22_S71>A(1)|p.V22_Y64del(1)|p.A20_Q72del(1)|p.A20_S111del(1)|p.D32_H36del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TACCTGGACTCTGGAATCCAT	0.488	S33C(SKMEL1_SKIN)|S33F(SW1573_LUNG)|S33Y(SW48_LARGE_INTESTINE)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.001984	0	7	31										T	41266101	C	T	41266101	3	4	46	1	0	0	0	0	1	0	0	0	4016	913	32	1	104	1	CTNNB1	3	41266101	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	809919	41266101	156756329	335	12032										
ZNF197	10168	broad.mit.edu	37	chr3	44684773	44684773	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgggaaaacctttattatGagcaaaagttttatggtcca	9	5	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:44684773G>T	uc003cnm.2	+	6	2357	c.2151G>T	c.(2149-2151)ATG>ATT	p.M717I	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	717	C2H2-type 13.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		CCTTTATTATGAGCAAAAGTT	0.423													1	0	5.73332e-34	0.01441	6.08376e-34	65	88										T	44684773	G	T	44684773	3	4	46	1	0	0	0	0	1	0	0	0	17756	1290	45	3	2169	3	ZNF197	3	44684773	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3418672	44684773	153337657	336	12033										
ZNF35	7584	broad.mit.edu	37	chr3	44700379	44700379	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagagaaaagaaagatttcaGacaagtgatagtgaatgact	11	3	1	7			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:44700379G>T	uc003cnq.2	+	4	745	c.524G>T	c.(523-525)AGA>ATA	p.R175I	ZNF35_uc003cnr.2_Missense_Mutation_p.R15I	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	175	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		AAAGATTTCAGACAAGTGATA	0.383													1	0	3.12436e-70	0.01441	3.32673e-70	109	38										T	44700379	G	T	44700379	3	4	46	1	0	0	0	0	1	0	0	0	17859	942	33	3	534	3	ZNF35	3	44700379	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	15606	44700379	153322051	337	12034										
CLEC3B	7123	broad.mit.edu	37	chr3	45077285	45077285	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctacaagaactgggagactGagatcaccgcgcaacccgat	10	13	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:45077285G>A	uc003cok.3	+	3	574	c.478G>A	c.(478-480)GAG>AAG	p.E160K	CLEC3B_uc003col.2_Missense_Mutation_p.E118K	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	160	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGGGAGACTGAGATCACCGC	0.662													0	0	0	0.005443	0	23	10										A	45077285	G	A	45077285	3	1	46	1	0	0	0	0	1	0	0	0	3511	1291	45	1	488	1	CLEC3B	3	45077285	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	376906	45077285	152945145	338	12035										
KLHL18	23276	broad.mit.edu	37	chr3	47378043	47378043	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggtgattccctgaatgtggTggaagtgttcgaccccattg	13	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:47378043T>C	uc003crd.2	+	7	1043	c.917T>C	c.(916-918)GTG>GCG	p.V306A	KLHL18_uc003crc.2_Missense_Mutation_p.V306A|KLHL18_uc011bav.1_Missense_Mutation_p.V194A|KLHL18_uc010hjq.1_Missense_Mutation_p.V162A	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	306	Kelch 1.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CTGAATGTGGTGGAAGTGTTC	0.478													0	0	0	0.008361	0	30	14										C	47378043	T	C	47378043	3	2	46	1	0	0	0	0	1	0	0	0	8373	1696	59	5	943	5	KLHL18	3	47378043	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2300758	47378043	150644387	339	12036										
SMARCC1	6599	broad.mit.edu	37	chr3	47676775	47676775	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tactttcttcttcccagtatCactttctctttctttacatg	2	12	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:47676775C>T	uc003crq.2	-	24	2669	c.2551G>A	c.(2551-2553)GAT>AAT	p.D851N	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.D742N	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	851	Glu-rich.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TTCCCAGTATCACTTTCTCTT	0.433													0	0	0	0.004289	0	39	20										T	47676775	C	T	47676775	3	4	46	1	0	0	0	0	1	0	0	0	14775	826	29	1	786	1	SMARCC1	3	47676775	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	298732	47676775	150345655	340	12037										
ZNF589	51385	broad.mit.edu	37	chr3	48309504	48309504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctacacaatcatcctattcCaggtttccatgcaggaaatc	6	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48309504C>T	uc003csl.3	+	4	389	c.323C>T	c.(322-324)CCA>CTA	p.P108L	ZNF589_uc010hjt.1_Missense_Mutation_p.P105L|ZNF589_uc003csn.2_RNA|ZNF589_uc011bbg.1_Missense_Mutation_p.P107L|ZNF589_uc003csm.2_Intron	NM_016089	NP_057173	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	108	KRAB.				regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CATCCTATTCCAGGTTTCCAT	0.507													0	0	0	0.004007	0	17	60										T	48309504	C	T	48309504	3	4	46	1	0	0	0	0	1	0	0	0	18018	594	21	2	337	2	ZNF589	3	48309504	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	632729	48309504	149712926	341	12038										
PLXNB1	5364	broad.mit.edu	37	chr3	48447188	48447188	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcagggccactcgcgccccGaggtctccggagtagttcta	13	14	2	0	rs143335184		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48447188G>A	uc003csw.2	-	37	6516	c.6246C>T	c.(6244-6246)CTC>CTT	p.L2082L	PLXNB1_uc003cst.2_Silent_p.L532L|PLXNB1_uc003csu.2_Silent_p.L1899L|PLXNB1_uc003csx.2_Silent_p.L2082L	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	2082	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTCGCGCCCCGAGGTCTCCGG	0.617													0	0	0	0.00308	0	7	17										A	48447188	G	A	48447188	2	1	46	1	0	0	0	0	0	0	0	1	12123	1045	37	1		1	PLXNB1	3	48447188	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	137684	48447188	149575242	342	12039										
CCDC51	79714	broad.mit.edu	37	chr3	48474369	48474369	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggagtaaagccttcagctCctgtagtcgcacacggttca	10	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48474369C>T	uc003csz.2	-	4	806	c.685G>A	c.(685-687)GAG>AAG	p.E229K	PLXNB1_uc003csx.2_5'Flank|CCDC51_uc003cta.2_Missense_Mutation_p.E120K|CCDC51_uc003ctb.2_Missense_Mutation_p.E120K|CCDC51_uc003ctc.2_Missense_Mutation_p.E229K|CCDC51_uc003ctd.2_Missense_Mutation_p.E120K	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	229						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCTTCAGCTCCTGTAGTCGC	0.597													0	0	0	0.00333	0	26	89										T	48474369	C	T	48474369	3	4	46	1	0	0	0	0	1	0	0	0	2821	864	30	1	554	1	CCDC51	3	48474369	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	27181	48474369	149548061	343	12040										
ATRIP	84126	broad.mit.edu	37	chr3	48506933	48506933	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggaaaccgatgtggaagacCccgaggtggagtgtggctga	17	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48506933C>G	uc003ctf.1	+	13	2388	c.2356C>G	c.(2356-2358)CCC>GCC	p.P786A	ATRIP_uc011bbj.1_Missense_Mutation_p.P659A|ATRIP_uc003ctg.1_Missense_Mutation_p.P759A|TREX1_uc010hjy.2_5'UTR|TREX1_uc003ctj.2_5'UTR|TREX1_uc003ctk.2_5'Flank|TREX1_uc010hjz.2_5'Flank|TREX1_uc010hka.2_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	786					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTGGAAGACCCCGAGGTGGA	0.587								Other_conserved_DNA_damage_response_genes			OREG0015557	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	13	27										G	48506933	C	G	48506933	3	3	46	1	0	0	0	0	1	0	0	0	1205	623	22	4	2406	4	ATRIP	3	48506933	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	32564	48506933	149515497	344	12041										
COL7A1	1294	broad.mit.edu	37	chr3	48602351	48602351	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgctgcctgtcacagcccGatggtaccagcgcagggtgt	14	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48602351G>A	uc003ctz.2	-	117	8684	c.8683C>T	c.(8683-8685)CGG>TGG	p.R2895W	UCN2_uc003cty.1_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2895	Nonhelical region (NC2).|BPTI/Kunitz inhibitor.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCACAGCCCGATGGTACCAG	0.622													0	0	0	0.004007	0	13	69										A	48602351	G	A	48602351	3	1	46	1	0	0	0	0	1	0	0	0	3704	1057	37	1	159	1	COL7A1	3	48602351	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	95418	48602351	149420079	345	12042										
COL7A1	1294	broad.mit.edu	37	chr3	48626328	48626328	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccggccccaggccagtctGtaagctgtggctccagtgac	12	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48626328G>C	uc003ctz.2	-	18	2416	c.2415C>G	c.(2413-2415)TAC>TAG	p.Y805*		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	805	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGCCAGTCTGTAAGCTGTGG	0.617													0	0	0	0.008291	0	9	42										C	48626328	G	C	48626328	4	2	46	1	0	0	0	0	0	1	0	0	3704	1372	48	4	6823	4	COL7A1	3	48626328	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	23977	48626328	149396102	346	12043										
CELSR3	1951	broad.mit.edu	37	chr3	48664437	48664437	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccatctggggccttggagtCttcttgaccattggctgttg	12	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48664437C>G	uc003cuf.1	-	53	12103	c.12103G>C	c.(12103-12105)GAC>CAC	p.D4035H	SLC26A6_uc003cug.2_Missense_Mutation_p.D628H|SLC26A6_uc003cuh.2_Missense_Mutation_p.D649H|SLC26A6_uc010hke.2_Missense_Mutation_p.D481H|SLC26A6_uc003cuk.2_Missense_Mutation_p.D541H|SLC26A6_uc003cui.2_Missense_Mutation_p.D648H|SLC26A6_uc003cuj.2_Missense_Mutation_p.D630H|SLC26A6_uc011bbp.1_Missense_Mutation_p.D613H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCCTTGGAGTCTTCTTGACCA	0.592													0	0	0	0.005443	0	19	107										G	48664437	C	G	48664437	3	3	46	1	0	0	0	0	1	0	0	0	3223	913	32	1		1	CELSR3	3	48664437	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	38109	48664437	149357993	347	12044										
CELSR3	1951	broad.mit.edu	37	chr3	48671065	48671065	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcagtgcctgtgtgtccctCggtctggggtggcaagacca	15	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48671065C>T	uc003cuf.1	-	37	10209	c.10209G>A	c.(10207-10209)CCG>CCA	p.P3403P	SLC26A6_uc003cug.2_5'UTR|SLC26A6_uc003cuh.2_Silent_p.P9P|SLC26A6_uc010hke.2_5'UTR|SLC26A6_uc003cuk.2_Silent_p.P9P|SLC26A6_uc003cui.2_Silent_p.P9P|SLC26A6_uc003cuj.2_Silent_p.P9P|SLC26A6_uc011bbp.1_Silent_p.P9P	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGTGTCCCTCGGTCTGGGGT	0.577													0	0	0	0.01441	0	63	71										T	48671065	C	T	48671065	2	4	46	1	0	0	0	0	0	0	0	1	3223	871	31	1		1	CELSR3	3	48671065	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6628	48671065	149351365	348	12045										
WDR6	11180	broad.mit.edu	37	chr3	49044905	49044905	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtttggccgcgggcaacctCggagcttatactcctcccag	11	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49044905C>T	uc003cvj.2	+	1	269	c.131C>T	c.(130-132)TCG>TTG	p.S44L	WDR6_uc011bbx.1_Missense_Mutation_p.S44L|WDR6_uc011bby.1_Missense_Mutation_p.S44L|WDR6_uc010hkn.2_5'UTR|WDR6_uc011bbz.1_5'Flank	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	14					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CGGGCAACCTCGGAGCTTATA	0.627													0	0	0	0.001168	0	5	8										T	49044905	C	T	49044905	3	4	46	1	0	0	0	0	1	0	0	0	17307	893	31	1	133	1	WDR6	3	49044905	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	373840	49044905	148977525	349	12046										
WDR6	11180	broad.mit.edu	37	chr3	49050477	49050477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgccttcctacccccaggtGacttcctggtgtgtggtgac	12	13	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49050477G>A	uc003cvj.2	+	2	1738	c.1600G>A	c.(1600-1602)GAC>AAC	p.D534N	WDR6_uc011bbx.1_Silent_p.V362V|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Missense_Mutation_p.D478N|WDR6_uc011bbz.1_Missense_Mutation_p.D453N	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	504	WD 8.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		ACCCCCAGGTGACTTCCTGGT	0.622													0	0	0	0.010729	0	10	36										A	49050477	G	A	49050477	3	1	46	1	0	0	0	0	1	0	0	0	17307	1290	45	1	1606	1	WDR6	3	49050477	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5572	49050477	148971953	350	12047										
IMPDH2	3615	broad.mit.edu	37	chr3	49062461	49062461	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtggtggcagccaggagaGagcccatcatgactgcggac	15	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49062461G>C	uc003cvt.2	-	11	1255	c.1163C>G	c.(1162-1164)TCT>TGT	p.S388C		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	388	IMP binding.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	AGCCAGGAGAGAGCCCATCAT	0.577													0	0	0	0.013537	0	12	63										C	49062461	G	C	49062461	3	2	46	1	0	0	0	0	1	0	0	0	7727	942	33	1	397	1	IMPDH2	3	49062461	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	11984	49062461	148959969	351	12048										
QARS	5859	broad.mit.edu	37	chr3	49137494	49137494	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcatccgtagtgtggcctCgccctctgaaaacttgccct	8	15	2	1	rs143072084	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49137494C>T	uc003cvx.2	-	14	1200	c.1195G>A	c.(1195-1197)GAG>AAG	p.E399K	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.E254K|QARS_uc003cvy.2_Missense_Mutation_p.E254K|QARS_uc011bce.1_Missense_Mutation_p.E388K	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	399					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGTGTGGCCTCGCCCTCTGAA	0.557													0	0	0	0.012319	0	20	82										T	49137494	C	T	49137494	3	4	46	1	0	0	0	0	1	0	0	0	12871	893	31	1	1176	1	QARS	3	49137494	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	75033	49137494	148884936	352	12049										
C3orf62	375341	broad.mit.edu	37	chr3	49314209	49314209	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgggaataactaactccttCaaaggcccggtcaatggctg	10	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49314209C>T	uc003cwn.2	-	1	300	c.97G>A	c.(97-99)GAA>AAA	p.E33K	C3orf62_uc003cwm.2_5'Flank	NM_198562	NP_940964	Q6ZUJ4	CC062_HUMAN	hypothetical protein LOC375341	33											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTAACTCCTTCAAAGGCCCGG	0.527													0	0	0	0.004878	0	35	27										T	49314209	C	T	49314209	3	4	46	1	0	0	0	0	1	0	0	0	2238	835	29	1	718	1	C3orf62	3	49314209	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	176715	49314209	148708221	353	12050										
TCTA	6988	broad.mit.edu	37	chr3	49449866	49449866	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcgagggccagtcatggcgGagtcctggtctgggcaggcc	19	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49449866G>T	uc003cwv.3	+	1	228	c.7G>T	c.(7-9)GAG>TAG	p.E3*	RHOA_uc010hku.2_5'Flank|RHOA_uc003cwu.2_5'Flank	NM_022171	NP_071503	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	3	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGTCATGGCGGAGTCCTGGTC	0.706													1	0	1.62849e-17	0.004007	1.71795e-17	14	16										T	49449866	G	T	49449866	4	4	46	1	0	0	0	0	0	1	0	0	15713	1175	41	3	9	3	TCTA	3	49449866	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	135657	49449866	148572564	354	12051										
AMT	275	broad.mit.edu	37	chr3	49455127	49455127	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cattcttcttcagagaggggGaggggcagccactagtcaca	13	10	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49455127G>A	uc003cww.2	-	9	1187	c.1058C>T	c.(1057-1059)TCC>TTC	p.S353F	AMT_uc011bcn.1_3'UTR|AMT_uc003cwx.2_Missense_Mutation_p.S353F|AMT_uc011bco.1_Missense_Mutation_p.S309F|AMT_uc003cwy.2_Missense_Mutation_p.S305F|AMT_uc011bcp.1_Missense_Mutation_p.S256F|AMT_uc011bcq.1_Missense_Mutation_p.S297F	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	353					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAGAGAGGGGGAGGGGCAGCC	0.587													0	0	0	0.007291	0	20	25										A	49455127	G	A	49455127	3	1	46	1	0	0	0	0	1	0	0	0	589	1174	41	1	185	1	AMT	3	49455127	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5261	49455127	148567303	355	12052										
APEH	327	broad.mit.edu	37	chr3	49718651	49718651	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtgctacagccacccccaGagcaagagaatgtgcagtat	12	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49718651G>C	uc003cxf.2	+	15	1817	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	APEH_uc010hkw.1_Missense_Mutation_p.E473Q	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	473					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCACCCCCAGAGCAAGAGAA	0.617													0	0	0	0.00632	0	26	27										C	49718651	G	C	49718651	3	2	46	1	0	0	0	0	1	0	0	0	768	943	33	1	1475	1	APEH	3	49718651	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	263524	49718651	148303779	356	12053										
MST1	4485	broad.mit.edu	37	chr3	49724697	49724697	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagaagttctcttccaggccAttccggagagtgggcgtgta	13	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49724697A>T	uc003cxg.2	-	5	564	c.492T>A	c.(490-492)AAT>AAA	p.N164K	MST1_uc011bcs.1_Missense_Mutation_p.N164K|MST1_uc010hkx.2_Missense_Mutation_p.N85K|MST1_uc011bct.1_Missense_Mutation_p.N164K|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	150	Kringle 1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTTCCAGGCCATTCCGGAGAG	0.612													0	0	0	0.003163	0	15	22										T	49724697	A	T	49724697	3	4	46	1	0	0	0	0	1	0	0	0	9890	214	8	5	1741	5	MST1	3	49724697	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	6046	49724697	148297733	357	12054										
TMEM115	11070	broad.mit.edu	37	chr3	50396052	50396052	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccccatggtttgcttgagtGccaccaggacgccacctagg	11	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:50396052G>A	uc003dan.1	-	1	888	c.443C>T	c.(442-444)GCA>GTA	p.A148V		NM_007024	NP_008955	Q12893	TM115_HUMAN	PL6 protein	148	Helical; (Potential).				negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTGCTTGAGTGCCACCAGGAC	0.507													0	0	0	0.001855	0	14	14										A	50396052	G	A	50396052	3	1	46	1	0	0	0	0	1	0	0	0	16026	1319	46	2	620	2	TMEM115	3	50396052	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	671355	50396052	147626378	358	12055										
MANF	7873	broad.mit.edu	37	chr3	51426367	51426367	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacctgagcacagtggacctGaagaagctccgagttaaaga	12	9	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:51426367G>A	uc003dbc.2	+	4	467	c.405G>A	c.(403-405)CTG>CTA	p.L135L	RBM15B_uc003dbd.2_5'Flank	NM_006010	NP_006001	P55145	MANF_HUMAN	mesencephalic astrocyte-derived neurotrophic	132					response to unfolded protein	extracellular region	growth factor activity				0						CAGTGGACCTGAAGAAGCTCC	0.527											OREG0015594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	4										A	51426367	G	A	51426367	2	1	46	1	0	0	0	0	0	0	0	1	9223	1277	45	1		1	MANF	3	51426367	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1030315	51426367	146596063	359	12056										
RAD54L2	23132	broad.mit.edu	37	chr3	51672281	51672281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggatcgcttccgggactgtGgtagcagcggttggctgggg	19	8	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:51672281G>A	uc011bdt.1	+	11	1929	c.1804G>A	c.(1804-1806)GGT>AGT	p.G602S	RAD54L2_uc003dbh.2_Missense_Mutation_p.G193S|RAD54L2_uc011bdu.1_Missense_Mutation_p.G296S|RAD54L2_uc003dbj.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	602						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CCGGGACTGTGGTAGCAGCGG	0.522											OREG0015596	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	22	27										A	51672281	G	A	51672281	3	1	46	1	0	0	0	0	1	0	0	0	12994	1348	47	2	1842	2	RAD54L2	3	51672281	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	245914	51672281	146350149	360	12057										
PBRM1	55193	broad.mit.edu	37	chr3	52584525	52584526	+	Frame_Shift_Del	DEL	CC	CC	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taggcctctgagtgaagaagCcgctgggtctttggtggggg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:52584525_52584526delCC	uc003des.2	-	29	4820_4821	c.4808_4809delGG	c.(4807-4809)CGGfs	p.R1603fs	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Frame_Shift_Del_p.R1496fs|PBRM1_uc003der.2_Frame_Shift_Del_p.R1516fs|PBRM1_uc003det.2_Frame_Shift_Del_p.R1511fs|PBRM1_uc003deu.2_Frame_Shift_Del_p.R1566fs|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Frame_Shift_Del_p.R1548fs|PBRM1_uc010hmk.1_Frame_Shift_Del_p.R1523fs|PBRM1_uc003dey.2_Frame_Shift_Del_p.R1496fs	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1603					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AGTGAAGAAGCCGCTGGGTCTT	0.545			Mis|N|F|S|D|O		clear cell renal carcinoma|breast													15	65	---	---								-	52584526	CC	-	52584525	7	5	46	1	0	1	0	1	0	0	0	0	11491	726	26	0	268	0	PBRM1	3	52584525	Frame_Shift_Del	DEL	CC	TCGA-DK-A1AC-01A-11D-A13W-08	912244	52584525	145437905	361	12058										
ERC2	26059	broad.mit.edu	37	chr3	56114883	56114883	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatttttctttccttcacttCtaacatatctttcatgtcac	2	11	6	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:56114883C>G	uc003dhr.1	-	7	1859	c.1603G>C	c.(1603-1605)GAA>CAA	p.E535Q	ERC2_uc003dht.1_Missense_Mutation_p.E6Q	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	535	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCCTTCACTTCTAACATATCT	0.368													0	0	0	0.012319	0	22	23										G	56114883	C	G	56114883	3	3	46	1	0	0	0	0	1	0	0	0	5211	922	32	1	1304	1	ERC2	3	56114883	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3530358	56114883	141907547	362	12059										
CCDC66	285331	broad.mit.edu	37	chr3	56627024	56627024	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtactgctggagcaccctttCagtgctgtgaaacaagaact	10	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:56627024C>T	uc003dhz.2	+	8	1050	c.963C>T	c.(961-963)TTC>TTT	p.F321F	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Silent_p.F287F|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	321										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		AGCACCCTTTCAGTGCTGTGA	0.343													0	0	0	0.01441	0	49	147										T	56627024	C	T	56627024	2	4	46	1	0	0	0	0	0	0	0	1	2838	825	29	1		1	CCDC66	3	56627024	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	512141	56627024	141395406	363	12060										
FLNB	2317	broad.mit.edu	37	chr3	58106996	58106996	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgggaaggatcaggagttCaccgttgataccaggggggc	17	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:58106996C>T	uc003djj.2	+	20	3057	c.2892C>T	c.(2890-2892)TTC>TTT	p.F964F	FLNB_uc010hne.2_Silent_p.F964F|FLNB_uc003djk.2_Silent_p.F964F|FLNB_uc010hnf.2_Silent_p.F964F|FLNB_uc003djl.2_Silent_p.F795F|FLNB_uc003djm.2_Silent_p.F795F	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	964	Filamin 8.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ATCAGGAGTTCACCGTTGATA	0.562													0	0	0	0.010771	0	44	139										T	58106996	C	T	58106996	2	4	46	1	0	0	0	0	0	0	0	1	5934	825	29	1		1	FLNB	3	58106996	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1479972	58106996	139915434	364	12061										
FLNB	2317	broad.mit.edu	37	chr3	58109098	58109098	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgccctttgacccctctaaAgtcgtggcatcggggccagg	12	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:58109098A>T	uc003djj.2	+	21	3570	c.3405A>T	c.(3403-3405)AAA>AAT	p.K1135N	FLNB_uc010hne.2_Missense_Mutation_p.K1135N|FLNB_uc003djk.2_Missense_Mutation_p.K1135N|FLNB_uc010hnf.2_Missense_Mutation_p.K1135N|FLNB_uc003djl.2_Missense_Mutation_p.K966N|FLNB_uc003djm.2_Missense_Mutation_p.K966N	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1135	Interaction with FBLP1.|Filamin 10.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACCCCTCTAAAGTCGTGGCAT	0.592													0	0	0	0.01441	0	73	58										T	58109098	A	T	58109098	3	4	46	1	0	0	0	0	1	0	0	0	5934	69	3	5	3487	5	FLNB	3	58109098	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	2102	58109098	139913332	365	12062										
PXK	54899	broad.mit.edu	37	chr3	58377553	58377553	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagattttcagtgtctaatCaaacttctgccttcttgttt	5	8	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:58377553C>T	uc003djz.1	+	7	693	c.594C>T	c.(592-594)ATC>ATT	p.I198I	PXK_uc003djx.1_Silent_p.I198I|PXK_uc003djy.1_Silent_p.I181I|PXK_uc003dka.1_Silent_p.I198I|PXK_uc003dkb.1_Silent_p.I115I|PXK_uc003dkc.1_Silent_p.I181I|PXK_uc011bfe.1_Silent_p.I165I|PXK_uc010hnj.1_Silent_p.I165I|PXK_uc003dkd.1_Silent_p.I61I|PXK_uc010hnk.1_Intron	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	198	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AGTGTCTAATCAAACTTCTGC	0.388													0	0	0	0.01441	0	75	82										T	58377553	C	T	58377553	2	4	46	1	0	0	0	0	0	0	0	1	12849	816	29	1		1	PXK	3	58377553	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	268455	58377553	139644877	366	12063										
SYNPR	132204	broad.mit.edu	37	chr3	63600994	63600994	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcgggacagagatatctttCagatccaatggagaagcact	10	8	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:63600994C>T	uc003dlq.2	+	5	1004	c.635C>T	c.(634-636)TCA>TTA	p.S212L	SYNPR_uc003dlp.2_Missense_Mutation_p.S232L|SYNPR_uc011bfk.1_RNA|SYNPR_uc011bfl.1_RNA|SYNPR_uc010hnt.2_Missense_Mutation_p.S221L|SYNPR_uc011bfm.1_RNA	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	212	Cytoplasmic (Potential).|5 X approximate repeats.|1.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		AGATATCTTTCAGATCCAATG	0.468													0	0	0	0.001168	0	6	26										T	63600994	C	T	63600994	3	4	46	1	0	0	0	0	1	0	0	0	15456	838	29	1	745	1	SYNPR	3	63600994	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5223441	63600994	134421436	367	12064										
PRICKLE2	166336	broad.mit.edu	37	chr3	64142939	64142939	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatcagatccaccaggagctCattgcagacagtgcatacga	10	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:64142939C>T	uc003dmf.2	-	5	1085	c.499G>A	c.(499-501)GAG>AAG	p.E167K		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	167	LIM zinc-binding 1.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		ACCAGGAGCTCATTGCAGACA	0.577													0	0	0	0.012213	0	24	23										T	64142939	C	T	64142939	3	4	46	1	0	0	0	0	1	0	0	0	12487	835	29	1	2051	1	PRICKLE2	3	64142939	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	541945	64142939	133879491	368	12065										
KBTBD8	84541	broad.mit.edu	37	chr3	67054357	67054357	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaactatgcaaaccaccaaaTgacctgagagaagttgggat	9	8	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:67054357T>C	uc003dmy.2	+	3	1019	c.966T>C	c.(964-966)AAT>AAC	p.N322N	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	322										ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AACCACCAAATGACCTGAGAG	0.443													0	0	0	0.01441	0	71	77										C	67054357	T	C	67054357	2	2	46	1	0	0	0	0	0	0	0	1	7999	1461	51	5		5	KBTBD8	3	67054357	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2911418	67054357	130968073	369	12066										
TMF1	7110	broad.mit.edu	37	chr3	69074854	69074854	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggtccaaatgagtgatcatGagactcatcctatgttaatt	8	7	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:69074854G>A	uc003dnn.2	-	15	3116	c.2869C>T	c.(2869-2871)CAT>TAT	p.H957Y	TMF1_uc011bfx.1_Missense_Mutation_p.H960Y	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	957					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GAGTGATCATGAGACTCATCC	0.368													0	0	0	0.010818	0	30	72										A	69074854	G	A	69074854	3	1	46	1	0	0	0	0	1	0	0	0	16225	1290	45	1	424	1	TMF1	3	69074854	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2020497	69074854	128947576	370	12067										
UBA3	9039	broad.mit.edu	37	chr3	69112141	69112141	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttttgattacctgtggtgGataaagttccagcgtgcatt	10	6	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:69112141G>T	uc003dno.2	-	9	705	c.685C>A	c.(685-687)CCA>ACA	p.P229T	UBA3_uc003dnq.2_Missense_Mutation_p.P215T|UBA3_uc011bfy.1_Missense_Mutation_p.P52T|UBA3_uc011bfz.1_Missense_Mutation_p.P52T	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	229	Interaction with NEDD8.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		ACCTGTGGTGGATAAAGTTCC	0.388													1	0	8.27458e-37	0.01441	8.78895e-37	71	63										T	69112141	G	T	69112141	3	4	46	1	0	0	0	0	1	0	0	0	16826	1174	41	3	746	3	UBA3	3	69112141	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	37287	69112141	128910289	371	12068										
FOXP1	27086	broad.mit.edu	37	chr3	71037150	71037150	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggatcaatacttacgggctGaggggcggctttgggttctg	17	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:71037150G>A	uc003dol.2	-	10	1464	c.1141C>T	c.(1141-1143)CAG>TAG	p.Q381*	FOXP1_uc003dom.2_Nonsense_Mutation_p.Q305*|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Nonsense_Mutation_p.Q381*|FOXP1_uc003dop.2_Nonsense_Mutation_p.Q381*|FOXP1_uc003doq.1_Nonsense_Mutation_p.Q380*|FOXP1_uc003doi.2_Nonsense_Mutation_p.Q281*|FOXP1_uc003doj.2_Nonsense_Mutation_p.Q281*|FOXP1_uc003dok.2_Nonsense_Mutation_p.Q194*|FOXP1_uc003dor.1_Nonsense_Mutation_p.Q159*	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	381					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		CTTACGGGCTGAGGGGCGGCT	0.493			T	PAX5	ALL								0	0	0	0.01441	0	69	194										A	71037150	G	A	71037150	4	1	46	1	0	0	0	0	0	1	0	0	6026	1299	45	1	924	1	FOXP1	3	71037150	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1925009	71037150	126985280	372	12069										
PROS1	5627	broad.mit.edu	37	chr3	93611869	93611869	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacttcaatctttccaccacGaagtgcaatcaggagccacg	7	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:93611869G>A	uc003drb.3	-	10	1404	c.1063C>T	c.(1063-1065)CGT>TGT	p.R355C	PROS1_uc010hoo.2_Missense_Mutation_p.R224C|PROS1_uc003dqz.3_Missense_Mutation_p.R224C	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	355	Laminin G-like 1.		R -> H (in PROS1D).		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTTCCACCACGAAGTGCAATC	0.393													0	0	0	0.00308	0	8	120										A	93611869	G	A	93611869	3	1	46	1	0	0	0	0	1	0	0	0	12558	1058	37	1	991	1	PROS1	3	93611869	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	22574719	93611869	104410561	373	12070										
STX19	415117	broad.mit.edu	37	chr3	93733304	93733304	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctttttttgtattttacagcTagtccaaatttctctttagt	4	7	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:93733304T>C	uc003drh.1	-	2	1067	c.810A>G	c.(808-810)CTA>CTG	p.L270L	ARL13B_uc003drc.2_Intron|ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_001001850	NP_001001850	Q8N4C7	STX19_HUMAN	syntaxin 19	270	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity				0						ATTTTACAGCTAGTCCAAATT	0.328													0	0	0	0.005524	0	39	30										C	93733304	T	C	93733304	2	2	46	1	0	0	0	0	0	0	0	1	15341	1509	53	5		5	STX19	3	93733304	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	121435	93733304	104289126	374	12071										
MINA	84864	broad.mit.edu	37	chr3	97668720	97668720	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctctgccccatctcccgcaGagtaaggggggagtctgtgc	14	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:97668720G>A	uc003drz.1	-	7	1534	c.1028C>T	c.(1027-1029)TCT>TTT	p.S343F	MINA_uc003dry.1_Missense_Mutation_p.S14F|MINA_uc003dsa.1_Missense_Mutation_p.S342F|MINA_uc003dsb.1_Missense_Mutation_p.S343F|MINA_uc003dsc.1_Missense_Mutation_p.S342F|MINA_uc010hpa.1_RNA	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	343					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						ATCTCCCGCAGAGTAAGGGGG	0.522													0	0	0	0.001855	0	11	60										A	97668720	G	A	97668720	3	1	46	1	0	0	0	0	1	0	0	0	9586	942	33	1	385	1	MINA	3	97668720	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3935416	97668720	100353710	375	12072										
ABI3BP	25890	broad.mit.edu	37	chr3	100471769	100471769	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtctgaattaaagggtctttCagtccagatggcatctcttc	9	9	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:100471769C>G	uc003dun.2	-	33	2936	c.2851G>C	c.(2851-2853)GAA>CAA	p.E951Q	ABI3BP_uc003duj.2_Missense_Mutation_p.E531Q|ABI3BP_uc003duk.2_Missense_Mutation_p.E660Q|ABI3BP_uc003dul.2_Missense_Mutation_p.E781Q|ABI3BP_uc011bhd.1_Missense_Mutation_p.E905Q|ABI3BP_uc003dum.2_Missense_Mutation_p.E362Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	951						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						AAGGGTCTTTCAGTCCAGATG	0.373													0	0	0	0.004878	0	36	40										G	100471769	C	G	100471769	3	3	46	1	0	0	0	0	1	0	0	0	91	835	29	1	388	1	ABI3BP	3	100471769	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2803049	100471769	97550661	376	12073										
MYH15	22989	broad.mit.edu	37	chr3	108102561	108102561	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttatacttggaaaggtattGattggcttgtgtttcctata	9	5	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:108102561G>A	uc003dxa.1	-	41	5764	c.5707C>T	c.(5707-5709)CAA>TAA	p.Q1903*		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1903	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GAAAGGTATTGATTGGCTTGT	0.333													0	0	0	0.005443	0	28	102										A	108102561	G	A	108102561	4	1	46	1	0	0	0	0	0	1	0	0	10034	1299	45	1	141	1	MYH15	3	108102561	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7630792	108102561	89919869	377	12074										
MYH15	22989	broad.mit.edu	37	chr3	108139937	108139937	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcagcatacttacttaccaCtctcactccacagctttgtc	4	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:108139937C>G	uc003dxa.1	-	29	3944	c.3887G>C	c.(3886-3888)AGT>ACT	p.S1296T		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1296	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTACTTACCACTCTCACTCCA	0.463													0	0	0	0.013726	0	34	133										G	108139937	C	G	108139937	3	3	46	1	0	0	0	0	1	0	0	0	10034	565	20	4	2009	4	MYH15	3	108139937	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	37376	108139937	89882493	378	12075										
KIAA2018	205717	broad.mit.edu	37	chr3	113377710	113377710	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggaatcaatacattggctGaagcgcagggtttggcagca	13	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:113377710G>A	uc003eam.2	-	7	3230	c.2819C>T	c.(2818-2820)TCA>TTA	p.S940L	KIAA2018_uc003eal.2_Missense_Mutation_p.S884L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	940					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TACATTGGCTGAAGCGCAGGG	0.418													0	0	0	0.01441	0	127	123										A	113377710	G	A	113377710	3	1	46	1	0	0	0	0	1	0	0	0	8268	1294	45	1	3922	1	KIAA2018	3	113377710	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5237773	113377710	84644720	379	12076										
DRD3	1814	broad.mit.edu	37	chr3	113850098	113850098	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttctaagctgagcttgggCgctatggtgggactcaggga	15	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:113850098C>T	uc003ebd.2	-	7	1296	c.873G>A	c.(871-873)GCG>GCA	p.A291A	DRD3_uc010hqn.1_Silent_p.A291A|DRD3_uc003ebb.1_Intron|DRD3_uc003ebc.1_Silent_p.A291A	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	291	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TGAGCTTGGGCGCTATGGTGG	0.542													0	0	0	0.008361	0	27	222										T	113850098	C	T	113850098	2	4	46	1	0	0	0	0	0	0	0	1	4758	755	27	2		2	DRD3	3	113850098	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	472388	113850098	84172332	380	12077										
RABL3	285282	broad.mit.edu	37	chr3	120424963	120424963	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtgtacgaaaataataccTaaaataatcagagaaaacaa	5	6	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:120424963T>C	uc003edx.2	-	4	299	c.269_splice	c.e4-1	p.G90_splice		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3						small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		AAATAATACCTAAAATAATCA	0.373													0	0	0	0.008291	0	11	38										C	120424963	T	C	120424963	5	2	46	1	0	0	0	0	0	0	1	0	12972	1536	53	5	463	5	RABL3	3	120424963	Splice_Site	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	6574865	120424963	77597467	381	12078										
EAF2	55840	broad.mit.edu	37	chr3	121554153	121554153	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaatagcgcagcgggattCtcacacctagaccgtcgcga	11	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:121554153C>T	uc003een.2	+	1	120	c.21C>T	c.(19-21)TTC>TTT	p.F7F	IQCB1_uc010hre.1_5'Flank|IQCB1_uc003eek.2_5'Flank|IQCB1_uc010hrf.1_5'Flank|EAF2_uc003eem.2_RNA|EAF2_uc003eeo.2_5'UTR	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	7					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)		CAGCGGGATTCTCACACCTAG	0.557													0	0	0	0.004007	0	12	16										T	121554153	C	T	121554153	2	4	46	1	0	0	0	0	0	0	0	1	4876	912	32	1		1	EAF2	3	121554153	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1129190	121554153	76468277	382	12079										
SEMA5B	54437	broad.mit.edu	37	chr3	122658317	122658317	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgagtctgaagaggtagttCctgtgaaaatggaaacagac	12	6	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:122658317C>T	uc003efz.1	-	5	733	c.429G>A	c.(427-429)AGG>AGA	p.R143R	SEMA5B_uc011bju.1_Silent_p.R85R|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.R143R|SEMA5B_uc010hro.1_Silent_p.R85R|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	143	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		AGAGGTAGTTCCTGTGAAAAT	0.537													0	0	0	0.001984	0	7	36										T	122658317	C	T	122658317	2	4	46	1	0	0	0	0	0	0	0	1	14038	869	30	1		1	SEMA5B	3	122658317	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1104164	122658317	75364113	383	12080										
ROPN1	54763	broad.mit.edu	37	chr3	123699230	123699230	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tactcggctgcccactggatGaggtcctgcggctgcaccct	12	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:123699230G>A	uc003eha.2	-	3	440	c.99C>T	c.(97-99)CTC>CTT	p.L33L	ROPN1_uc003ehb.1_RNA|ROPN1_uc003ehc.1_RNA	NM_017578	NP_060048	Q9HAT0	ROP1A_HUMAN	ropporin	33	RIIa.				signal transduction		cAMP-dependent protein kinase regulator activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.148)		CCCACTGGATGAGGTCCTGCG	0.597													0	0	0	0.003954	0	11	25										A	123699230	G	A	123699230	2	1	46	1	0	0	0	0	0	0	0	1	13523	1277	45	1		1	ROPN1	3	123699230	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1040913	123699230	74323200	384	12081										
KLF15	28999	broad.mit.edu	37	chr3	126071555	126071555	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagatgctgtcctggctctCggtgcccaggcctccaccat	10	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:126071555C>T	uc011bkk.1	-	2	393	c.211G>A	c.(211-213)GAG>AAG	p.E71K		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	71						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		TCCTGGCTCTCGGTGCCCAGG	0.652													0	0	0	0.004672	0	3	2										T	126071555	C	T	126071555	3	4	46	1	0	0	0	0	1	0	0	0	8343	893	31	1	1047	1	KLF15	3	126071555	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2372325	126071555	71950875	385	12082										
CHCHD6	84303	broad.mit.edu	37	chr3	126676358	126676358	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgctgtgctcggacctggtCaaggcataccagcgctgcgt	13	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:126676358C>T	uc003ejf.1	+	7	704	c.666C>T	c.(664-666)GTC>GTT	p.V222V	CHCHD6_uc010hsj.1_Silent_p.V223V	NM_032343	NP_115719	Q9BRQ6	CHCH6_HUMAN	coiled-coil-helix-coiled-coil-helix domain	222	CHCH.										0						CGGACCTGGTCAAGGCATACC	0.647													0	0	0	0.001168	0	6	4										T	126676358	C	T	126676358	2	4	46	1	0	0	0	0	0	0	0	1	3320	813	29	1		1	CHCHD6	3	126676358	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	604803	126676358	71346072	386	12083										
PLXND1	23129	broad.mit.edu	37	chr3	129293326	129293326	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcccatggcacagttataGaccatgactggggagacacg	12	11	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:129293326G>A	uc003emx.2	-	12	2638	c.2538C>T	c.(2536-2538)GTC>GTT	p.V846V		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	846	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CACAGTTATAGACCATGACTG	0.652													0	0	0	0.004482	0	9	21										A	129293326	G	A	129293326	2	1	46	1	0	0	0	0	0	0	0	1	12127	929	33	1		1	PLXND1	3	129293326	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2616968	129293326	68729104	387	12084										
ACPP	55	broad.mit.edu	37	chr3	132071660	132071660	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttgacggaattgtactttGagaaggggtaagtgactaag	13	4	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:132071660G>A	uc010htp.2	+	9	1051	c.961G>A	c.(961-963)GAG>AAG	p.E321K	ACPP_uc003eon.3_Missense_Mutation_p.E288K|ACPP_uc003eop.3_Missense_Mutation_p.E321K	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	321						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						ATTGTACTTTGAGAAGGGGTA	0.433													0	0	0	0.00499	0	17	94										A	132071660	G	A	132071660	3	1	46	1	0	0	0	0	1	0	0	0	167	1291	45	1	995	1	ACPP	3	132071660	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2778334	132071660	65950770	388	12085										
DNAJC13	23317	broad.mit.edu	37	chr3	132169512	132169512	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatacaactgctataagcatCactggagtgactcaagaaaa	8	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:132169512C>T	uc003eor.2	+	6	423	c.358C>T	c.(358-360)CAC>TAC	p.H120Y	DNAJC13_uc010htq.1_Missense_Mutation_p.H120Y	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	120							heat shock protein binding			ovary(1)|breast(1)	2						CTATAAGCATCACTGGAGTGA	0.323													0	0	0	0.01441	0	60	41										T	132169512	C	T	132169512	3	4	46	1	0	0	0	0	1	0	0	0	4632	826	29	1	376	1	DNAJC13	3	132169512	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	97852	132169512	65852918	389	12086										
AMOTL2	51421	broad.mit.edu	37	chr3	134077396	134077397	+	Frame_Shift_Ins	INS	-	-	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttacccagagaggctgctcINStctggctactgctgcacccc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:134077396_134077397insT	uc003eqf.2	-	9	2557_2558	c.2440_2441insA	c.(2440-2442)AGAfs	p.R814fs	AMOTL2_uc003eqg.1_Frame_Shift_Ins_p.R757fs|AMOTL2_uc003eqh.1_Frame_Shift_Ins_p.R754fs|AMOTL2_uc010htx.1_5'Flank|AMOTL2_uc003eqe.1_Frame_Shift_Ins_p.R382fs	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	756										large_intestine(1)	1						AGAGGCTGCTCTCTGGCTACTG	0.629											OREG0015814	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						8	44	---	---								T	134077397	-	T	134077396	7	5	46	1	0	1	1	0	0	0	0	0	584	913	32	0	80	0	AMOTL2	3	134077396	Frame_Shift_Ins	INS	-	TCGA-DK-A1AC-01A-11D-A13W-08	1907884	134077396	63945034	390	12087										
CEP70	80321	broad.mit.edu	37	chr3	138256169	138256169	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcttgctccgttcgttttttCttataatgctggcacttcac	6	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:138256169C>T	uc003esl.2	-	7	684	c.486G>A	c.(484-486)AAG>AAA	p.K162K	CEP70_uc011bmk.1_Silent_p.K142K|CEP70_uc011bml.1_Silent_p.K144K|CEP70_uc011bmm.1_Silent_p.K10K|CEP70_uc003esm.2_Silent_p.K162K|CEP70_uc003esn.2_Silent_p.K162K	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	162	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TTCGTTTTTTCTTATAATGCT	0.343													0	0	0	0.010729	0	11	41										T	138256169	C	T	138256169	2	4	46	1	0	0	0	0	0	0	0	1	3259	912	32	1		1	CEP70	3	138256169	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4178773	138256169	59766261	391	12088										
FOXL2	668	broad.mit.edu	37	chr3	138665349	138665349	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccggacagcgtgagcctcttCtccgcgctctcgcggatcgc	12	17	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:138665349C>T	uc003esw.2	-	1	634	c.216G>A	c.(214-216)GAG>GAA	p.E72E	uc003esv.1_5'Flank|C3orf72_uc003esx.1_5'Flank|C3orf72_uc011bmr.1_5'Flank	NM_023067	NP_075555	P58012	FOXL2_HUMAN	forkhead box L2	72	Fork-head.				convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			ovary(266)|large_intestine(1)|skin(1)	268						TGAGCCTCTTCTCCGCGCTCT	0.632			Mis		granulosa-cell tumour of the ovary		Blepharophimosis|ptosis and epicanthus inversus Types I|II; Premature ovarian failure type III						0	0	0	0.012319	0	21	27										T	138665349	C	T	138665349	2	4	46	1	0	0	0	0	0	0	0	1	6017	912	32	1		1	FOXL2	3	138665349	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	409180	138665349	59357081	392	12089										
RBP1	5947	broad.mit.edu	37	chr3	139258348	139258348	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctcgttgaccaacatcttCcagtacccagtgaagtcgac	7	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:139258348C>T	uc003eti.2	-	1	324	c.213G>A	c.(211-213)TGG>TGA	p.W71*	RBP1_uc011bmx.1_Nonsense_Mutation_p.W71*|RBP1_uc010huj.2_RNA|RBP1_uc011bmy.1_Nonsense_Mutation_p.W71*	NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	9						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CCAACATCTTCCAGTACCCAG	0.682													0	0	0	0.001984	0	6	10										T	139258348	C	T	139258348	4	4	46	1	0	0	0	0	0	1	0	0	13155	856	30	1	464	1	RBP1	3	139258348	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	592999	139258348	58764082	393	12090										
ACPL2	92370	broad.mit.edu	37	chr3	141006166	141006166	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctctctaggaaaccgtatCacccaaaactggaagctttc	6	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:141006166C>T	uc003etu.2	+	7	675	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	ACPL2_uc003etv.2_Missense_Mutation_p.H126Y|ACPL2_uc011bna.1_Missense_Mutation_p.H88Y|ACPL2_uc011bnb.1_Missense_Mutation_p.H109Y	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	126						extracellular region	acid phosphatase activity			skin(1)	1						GAAACCGTATCACCCAAAACT	0.463													0	0	0	0.004289	0	36	119										T	141006166	C	T	141006166	3	4	46	1	0	0	0	0	1	0	0	0	166	826	29	1	390	1	ACPL2	3	141006166	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1747818	141006166	57016264	394	12091										
GRK7	131890	broad.mit.edu	37	chr3	141526645	141526645	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggtcagtaaagaggatctGaagcaaagaactctgcaaga	11	6	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:141526645G>A	uc011bnd.1	+	3	1293	c.1209G>A	c.(1207-1209)CTG>CTA	p.L403L		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	403	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						AAGAGGATCTGAAGCAAAGAA	0.433													0	0	0	0.008291	0	10	80										A	141526645	G	A	141526645	2	1	46	1	0	0	0	0	0	0	0	1	6794	1277	45	1		1	GRK7	3	141526645	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	520479	141526645	56495785	395	12092										
ATP1B3	483	broad.mit.edu	37	chr3	141626055	141626055	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accgcattggaatatacattCagtaggtctgatccaacttc	7	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:141626055C>T	uc003eug.1	+	3	459	c.285C>T	c.(283-285)TTC>TTT	p.F95F	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Silent_p.F81F	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	95	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						AATATACATTCAGTAGGTCTG	0.363													0	0	0	0.00632	0	28	84										T	141626055	C	T	141626055	2	4	46	1	0	0	0	0	0	0	0	1	1134	825	29	1		1	ATP1B3	3	141626055	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	99410	141626055	56396375	396	12093										
TRPC1	7220	broad.mit.edu	37	chr3	142509894	142509894	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agacattaaaagactctggtAtgaagggttggaagactttt	11	4	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:142509894A>G	uc003evc.2	+	8	1467	c.1331A>G	c.(1330-1332)TAT>TGT	p.Y444C	TRPC1_uc003evb.2_Missense_Mutation_p.Y410C|TRPC1_uc011bni.1_Missense_Mutation_p.Y11C	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	444	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AGACTCTGGTATGAAGGGTTG	0.328													0	0	0	0.008871	0	18	68										G	142509894	A	G	142509894	3	3	46	1	0	0	0	0	1	0	0	0	16575	449	16	5	1255	5	TRPC1	3	142509894	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	883839	142509894	55512536	397	12094										
PLSCR5	389158	broad.mit.edu	37	chr3	146311816	146311816	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcagggtgcaagatcgcagaGtggaacagaaagtacgattg	14	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:146311816G>C	uc003ewb.2	-	4	1348	c.344C>G	c.(343-345)ACT>AGT	p.T115S	PLSCR5_uc010hvb.2_Missense_Mutation_p.T103S|PLSCR5_uc010hvc.2_Missense_Mutation_p.T115S	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	115											0						AGATCGCAGAGTGGAACAGAA	0.458													0	0	0	0.00623	0	40	135										C	146311816	G	C	146311816	3	2	46	1	0	0	0	0	1	0	0	0	12113	1029	36	4	487	4	PLSCR5	3	146311816	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3801922	146311816	51710614	398	12095										
RNF13	11342	broad.mit.edu	37	chr3	149678727	149678727	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtcatttggggctttatcgGaatcccgctcacatcagaac	9	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:149678727G>A	uc003exn.3	+	11	1766	c.982G>A	c.(982-984)GAA>AAA	p.E328K	RNF13_uc003exp.3_Missense_Mutation_p.E328K|RNF13_uc010hvh.2_Missense_Mutation_p.E209K	NM_007282	NP_009213	O43567	RNF13_HUMAN	ring finger protein 13	328	Cytoplasmic (Potential).				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGCTTTATCGGAATCCCGCTC	0.413													0	0	0	0.012319	0	23	59										A	149678727	G	A	149678727	3	1	46	1	0	0	0	0	1	0	0	0	13437	1175	41	1	1016	1	RNF13	3	149678727	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3366911	149678727	48343703	399	12096										
RAP2B	5912	broad.mit.edu	37	chr3	152880887	152880887	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggagggcaaggccctggcTgaggagtggagctgcccctt	19	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:152880887T>C	uc003ezr.2	+	1	859	c.405T>C	c.(403-405)GCT>GCC	p.A135A		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	135					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			AGGCCCTGGCTGAGGAGTGGA	0.632													0	0	0	0.003163	0	13	20										C	152880887	T	C	152880887	2	2	46	1	0	0	0	0	0	0	0	1	13041	1567	55	5		5	RAP2B	3	152880887	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	3202160	152880887	45141543	400	12097										
MME	4311	broad.mit.edu	37	chr3	154886393	154886393	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtatggaaacttttcctgGgacctggcaggtggacagca	13	9	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:154886393G>A	uc010hvr.1	+	19	2104	c.1893G>A	c.(1891-1893)TGG>TGA	p.W631*	MME_uc003fab.1_Nonsense_Mutation_p.W631*|MME_uc003fac.1_Nonsense_Mutation_p.W631*|MME_uc003fad.1_Nonsense_Mutation_p.W631*|MME_uc003fae.1_Nonsense_Mutation_p.W631*	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	631	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	ACTTTTCCTGGGACCTGGCAG	0.408													0	0	0	0.00632	0	28	107										A	154886393	G	A	154886393	4	1	46	1	0	0	0	0	0	1	0	0	9645	1241	43	2	1963	2	MME	3	154886393	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2005506	154886393	43136037	401	12098										
SLC33A1	9197	broad.mit.edu	37	chr3	155571662	155571662	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtccccttcccggcccgctGagtccaaatgactgtcatcc	8	17	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:155571662G>A	uc003fan.3	-	1	506	c.125C>T	c.(124-126)TCA>TTA	p.S42L	SLC33A1_uc003fao.1_Missense_Mutation_p.S42L	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	42	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCGGCCCGCTGAGTCCAAATG	0.602													0	0	0	0.013537	0	11	47										A	155571662	G	A	155571662	3	1	46	1	0	0	0	0	1	0	0	0	14566	1294	45	1	1548	1	SLC33A1	3	155571662	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	685269	155571662	42450768	402	12099										
ARL14	80117	broad.mit.edu	37	chr3	160395402	160395402	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgggctggtgtatgttgtgGacagtacagacaaacagcga	14	6	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:160395402G>A	uc003fdq.2	+	1	455	c.268G>A	c.(268-270)GAC>AAC	p.D90N		NM_025047	NP_079323	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	90					small GTPase mediated signal transduction	intracellular	GTP binding				0			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			GTATGTTGTGGACAGTACAGA	0.433													0	0	0	0.001855	0	12	82										A	160395402	G	A	160395402	3	1	46	1	0	0	0	0	1	0	0	0	930	1174	41	1	270	1	ARL14	3	160395402	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4823740	160395402	37627028	403	12100										
BCHE	590	broad.mit.edu	37	chr3	165548500	165548500	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgtttgggttccacatctCtgatccatggaagcctggaa	11	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:165548500C>G	uc003fem.3	-	2	482	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	108					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TTCCACATCTCTGATCCATGG	0.393													0	0	0	0.01441	0	64	41										G	165548500	C	G	165548500	3	3	46	1	0	0	0	0	1	0	0	0	1358	922	32	1	1498	1	BCHE	3	165548500	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5153098	165548500	32473930	404	12101										
ZBBX	79740	broad.mit.edu	37	chr3	167045793	167045793	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atttccggttctccattgacTtaacacttcctgaaaggact	6	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:167045793T>A	uc003fep.2	-	11	1122	c.799A>T	c.(799-801)AGT>TGT	p.S267C	ZBBX_uc011bpc.1_Missense_Mutation_p.S267C|ZBBX_uc003feq.2_Missense_Mutation_p.S238C	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	267						intracellular	zinc ion binding			ovary(2)	2						CTCCATTGACTTAACACTTCC	0.348													0	0	0	0.01441	0	49	178										A	167045793	T	A	167045793	3	1	46	1	0	0	0	0	1	0	0	0	17513	1609	56	5	1647	5	ZBBX	3	167045793	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1497293	167045793	30976637	405	12102										
SLC2A2	6514	broad.mit.edu	37	chr3	170725017	170725017	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagagcggttggagcaatttCaccgatatacataggaacca	11	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:170725017C>T	uc003fhe.1	-	5	841	c.532G>A	c.(532-534)GAA>AAA	p.E178K	SLC2A2_uc003fhf.1_Missense_Mutation_p.E5K|SLC2A2_uc011bpu.1_Missense_Mutation_p.E51K	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	178	Helical; Name=4; (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GGAGCAATTTCACCGATATAC	0.428													0	0	0	0.008361	0	30	28										T	170725017	C	T	170725017	3	4	46	1	0	0	0	0	1	0	0	0	14544	835	29	1	1070	1	SLC2A2	3	170725017	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3679224	170725017	27297413	406	12103										
TNIK	23043	broad.mit.edu	37	chr3	170786662	170786662	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggtatgtagatatcataaGagtttcctgaatcaacatca	7	6	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:170786662G>A	uc003fhh.2	-	30	4019	c.3674C>T	c.(3673-3675)TCT>TTT	p.S1225F	TNIK_uc003fhi.2_Missense_Mutation_p.S1170F|TNIK_uc003fhj.2_Missense_Mutation_p.S1196F|TNIK_uc003fhk.2_Missense_Mutation_p.S1217F|TNIK_uc003fhl.2_Missense_Mutation_p.S1141F|TNIK_uc003fhm.2_Missense_Mutation_p.S1162F|TNIK_uc003fhn.2_Missense_Mutation_p.S1188F|TNIK_uc003fho.2_Missense_Mutation_p.S1133F|TNIK_uc003fhg.2_Missense_Mutation_p.S403F|TNIK_uc003fhp.2_Missense_Mutation_p.S157F	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1225	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GATATCATAAGAGTTTCCTGA	0.378													0	0	0	0.006214	0	10	49										A	170786662	G	A	170786662	3	1	46	1	0	0	0	0	1	0	0	0	16310	942	33	1	424	1	TNIK	3	170786662	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	61645	170786662	27235768	407	12104										
PLD1	5337	broad.mit.edu	37	chr3	171338225	171338225	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacaacttgctgtggacataGataagctcagttactaggtt	9	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:171338225G>C	uc003fhs.2	-	24	2795	c.2679C>G	c.(2677-2679)ATC>ATG	p.I893M	PLD1_uc003fht.2_Missense_Mutation_p.I855M|PLD1_uc003fhu.3_Missense_Mutation_p.I187M	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	893	Catalytic.|PLD phosphodiesterase 2.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TGTGGACATAGATAAGCTCAG	0.353													0	0	0	0.006122	0	16	116										C	171338225	G	C	171338225	3	2	46	1	0	0	0	0	1	0	0	0	12045	932	33	1	561	1	PLD1	3	171338225	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	551563	171338225	26684205	408	12105										
FNDC3B	64778	broad.mit.edu	37	chr3	172061911	172061911	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagtggctgtgaggtctcaGagtacagcgtggagatgacg	16	6	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:172061911G>A	uc003fhy.2	+	19	2285	c.2113G>A	c.(2113-2115)GAG>AAG	p.E705K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E705K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	705	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TGAGGTCTCAGAGTACAGCGT	0.527													0	0	0	0.00245	0	12	111										A	172061911	G	A	172061911	3	1	46	1	0	0	0	0	1	0	0	0	5970	943	33	1	2183	1	FNDC3B	3	172061911	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	723686	172061911	25960519	409	12106										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.007291	0	29	37										A	178936091	G	A	178936091	3	1	46	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6874180	178936091	19086339	410	12107										
MFN1	55669	broad.mit.edu	37	chr3	179066706	179066706	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggcgattactgcaatctttGaccagttactggagtttgtt	10	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:179066706G>A	uc003fjs.2	+	2	193	c.67G>A	c.(67-69)GAC>AAC	p.D23N	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.D51N	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	23	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TGCAATCTTTGACCAGTTACT	0.358													0	0	0	0.006999	0	38	163										A	179066706	G	A	179066706	3	1	46	1	0	0	0	0	1	0	0	0	9523	1290	45	1	69	1	MFN1	3	179066706	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	130615	179066706	18955724	411	12108										
LAMP3	27074	broad.mit.edu	37	chr3	182872117	182872117	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgttgctgctgcagtaggttGagaataatctctggtttctg	12	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:182872117G>A	uc003flh.3	-	2	336	c.112C>T	c.(112-114)CAA>TAA	p.Q38*		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	38	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GCAGTAGGTTGAGAATAATCT	0.398													0	0	0	0.01441	0	57	70										A	182872117	G	A	182872117	4	1	46	1	0	0	0	0	0	1	0	0	8619	1299	45	1	1158	1	LAMP3	3	182872117	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3805411	182872117	15150313	412	12109										
ECE2	9718	broad.mit.edu	37	chr3	183967552	183967552	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgcgggtaccgcgaagtcGagtactgggatcagcgctac	14	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:183967552G>A	uc003fni.3	+	1	108	c.70G>A	c.(70-72)GAG>AAG	p.E24K	ALG3_uc003fne.2_5'Flank|ALG3_uc011brc.1_5'Flank|ALG3_uc011brd.1_5'Flank|ALG3_uc011bre.1_5'Flank|ALG3_uc003fnf.1_5'Flank|ALG3_uc011brf.1_5'Flank|ECE2_uc003fnh.3_Missense_Mutation_p.E24K	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	24	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCGCGAAGTCGAGTACTGGGA	0.672											OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	19										A	183967552	G	A	183967552	3	1	46	1	0	0	0	0	1	0	0	0	4890	1059	37	1	72	1	ECE2	3	183967552	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1095435	183967552	14054878	413	12110										
TRA2B	6434	broad.mit.edu	37	chr3	185643391	185643391	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgaccgggtataatgccttCgggagcttcttctggatcta	12	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:185643391C>T	uc003fpv.2	-	3	470	c.194G>A	c.(193-195)CGA>CAA	p.R65Q	TRA2B_uc003fpt.2_5'Flank|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_5'UTR|TRA2B_uc003fpw.2_Missense_Mutation_p.R65Q	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	65	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						ATAATGCCTTCGGGAGCTTCT	0.463													0	0	0	0.003163	0	16	47										T	185643391	C	T	185643391	3	4	46	1	0	0	0	0	1	0	0	0	16431	884	31	1	700	1	TRA2B	3	185643391	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1675839	185643391	12379039	414	12111										
FETUB	26998	broad.mit.edu	37	chr3	186358310	186358310	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgctgcggagcaatgtctCcaccccagctggccctcaac	10	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:186358310C>T	uc010hyq.2	+	2	322	c.61C>T	c.(61-63)CCA>TCA	p.P21S	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Missense_Mutation_p.P21S|FETUB_uc003fqo.2_5'UTR|FETUB_uc010hyr.2_Missense_Mutation_p.P21S|FETUB_uc010hys.2_5'UTR|FETUB_uc003fqp.3_Missense_Mutation_p.P21S	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	21						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		AGCAATGTCTCCACCCCAGCT	0.592													0	0	0	0.01441	0	101	101										T	186358310	C	T	186358310	3	4	46	1	0	0	0	0	1	0	0	0	5821	855	30	1	63	1	FETUB	3	186358310	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	714919	186358310	11664120	415	12112										
MASP1	5648	broad.mit.edu	37	chr3	186969425	186969425	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggcaaggctctgcaccttCagcactttgtagcctgtgtc	10	13	2	0	rs116595107	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:186969425C>T	uc003frh.1	-	7	1340	c.1008G>A	c.(1006-1008)CTG>CTA	p.L336L	MASP1_uc003fri.2_Silent_p.L336L|MASP1_uc003frj.2_Silent_p.L305L|MASP1_uc003frk.1_Silent_p.L336L|MASP1_uc011bse.1_Silent_p.L310L	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	336	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TCTGCACCTTCAGCACTTTGT	0.552													0	0	0	0.01441	0	60	50										T	186969425	C	T	186969425	2	4	46	1	0	0	0	0	0	0	0	1	9322	813	29	1		1	MASP1	3	186969425	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	611115	186969425	11053005	416	12113										
TP63	8626	broad.mit.edu	37	chr3	189349350	189349350	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaccctacagtactgccctGacccttacatccagcggtga	7	17	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:189349350G>A	uc003fry.2	+	1	135	c.46G>A	c.(46-48)GAC>AAC	p.D16N	TP63_uc003frx.2_Missense_Mutation_p.D16N|TP63_uc003frz.2_Missense_Mutation_p.D16N|TP63_uc010hzc.1_Missense_Mutation_p.D16N	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	16	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTACTGCCCTGACCCTTACAT	0.378									Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.007835	0	40	125										A	189349350	G	A	189349350	3	1	46	1	0	0	0	0	1	0	0	0	16389	1290	45	1	48	1	TP63	3	189349350	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2379925	189349350	8673080	417	12114										
HES1	3280	broad.mit.edu	37	chr3	193854434	193854434	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctattatggagaaaagacGaagagcaagaataaatgaaa	10	4	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:193854434G>A	uc003ftq.1	+	2	373	c.137G>A	c.(136-138)CGA>CAA	p.R46Q	HES1_uc011bst.1_Missense_Mutation_p.R46Q	NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	46	Basic motif.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		GAGAAAAGACGAAGAGCAAGA	0.408													0	0	0	0.008291	0	10	14										A	193854434	G	A	193854434	3	1	46	1	0	0	0	0	1	0	0	0	7065	1058	37	1	143	1	HES1	3	193854434	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4505084	193854434	4167996	418	12115										
HES1	3280	broad.mit.edu	37	chr3	193855629	193855629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccaactgcatgacccagatCaatgccatgacctaccccgg	8	16	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:193855629C>T	uc003ftq.1	+	4	686	c.450C>T	c.(448-450)ATC>ATT	p.I150I		NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	150					endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		TGACCCAGATCAATGCCATGA	0.716													0	0	0	0.001168	0	5	18										T	193855629	C	T	193855629	2	4	46	1	0	0	0	0	0	0	0	1	7065	816	29	1		1	HES1	3	193855629	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1195	193855629	4166801	419	12116										
RNF168	165918	broad.mit.edu	37	chr3	196214289	196214289	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caatatcaatgcttagctttCttgccagttcctcatcactt	4	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:196214289C>G	uc003fwq.2	-	3	1077	c.539G>C	c.(538-540)AGA>ACA	p.R180T	RNF168_uc010iah.2_Missense_Mutation_p.R13T	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	180	MIU motif 1.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GCTTAGCTTTCTTGCCAGTTC	0.473													0	0	0	0.01441	0	90	290										G	196214289	C	G	196214289	3	3	46	1	0	0	0	0	1	0	0	0	13459	913	32	1	1192	1	RNF168	3	196214289	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2358660	196214289	1808141	420	12117										
BDH1	622	broad.mit.edu	37	chr3	197238892	197238892	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggcggtcagggcgtgtgtGacagcatcgatgacagggga	19	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:197238892G>A	uc003fxr.2	-	8	1308	c.906C>T	c.(904-906)GTC>GTT	p.V302V	BDH1_uc003fxs.2_Silent_p.V302V|BDH1_uc003fxt.2_Silent_p.V215V|BDH1_uc003fxu.2_Silent_p.V302V	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	302					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	GGGCGTGTGTGACAGCATCGA	0.572													0	0	0	0.003954	0	24	72										A	197238892	G	A	197238892	2	1	46	1	0	0	0	0	0	0	0	1	1390	1277	45	1		1	BDH1	3	197238892	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1024603	197238892	783538	421	12118										
MFSD7	84179	broad.mit.edu	37	chr4	676629	676629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaaggacggctccgagcgtCgcacagtcagtgccgtcatt	12	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:676629C>T	uc003gay.2	-	9	1262	c.1205G>A	c.(1204-1206)CGA>CAA	p.R402Q	MFSD7_uc003gaw.2_Missense_Mutation_p.R144Q|MFSD7_uc003gax.2_Missense_Mutation_p.R401Q|MFSD7_uc003gaz.2_Missense_Mutation_p.R283Q|MFSD7_uc003gba.2_Missense_Mutation_p.R305Q|MFSD7_uc003gbb.1_Missense_Mutation_p.R337Q	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	402					transmembrane transport	integral to membrane					0						CTCCGAGCGTCGCACAGTCAG	0.652													0	0	0	0.009096	0	4	6										T	676629	C	T	676629	3	4	46	1	0	0	0	0	1	0	0	0	9537	884	31	1	485	1	MFSD7	4	676629	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		676629	190477647	422	12119										
MFSD7	84179	broad.mit.edu	37	chr4	678583	678583	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcggggtggggggcacactCtcccacaggcagatggtgga	19	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:678583C>A	uc003gay.2	-	5	705	c.648G>T	c.(646-648)GAG>GAT	p.E216D	MFSD7_uc003gaw.2_5'UTR|MFSD7_uc003gax.2_Missense_Mutation_p.E216D|MFSD7_uc003gaz.2_Missense_Mutation_p.E97D|MFSD7_uc003gba.2_Missense_Mutation_p.E119D|MFSD7_uc003gbb.1_Missense_Mutation_p.E152D	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	216					transmembrane transport	integral to membrane					0						GGGGCACACTCTCCCACAGGC	0.657													1	0	4.96729e-08	0.008871	5.12554e-08	17	9										A	678583	C	A	678583	3	1	46	1	0	0	0	0	1	0	0	0	9537	912	32	3	1055	3	MFSD7	4	678583	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1954	678583	190475693	423	12120										
GAK	2580	broad.mit.edu	37	chr4	887189	887189	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgatgggagacttggggttCacgttgcgggcggccgcgat	19	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:887189C>T	uc003gbm.3	-	9	1165	c.966G>A	c.(964-966)GTG>GTA	p.V322V	GAK_uc003gbn.3_Silent_p.V243V|GAK_uc010ibk.1_Silent_p.V216V|GAK_uc003gbl.3_Silent_p.V186V	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	322					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		ACTTGGGGTTCACGTTGCGGG	0.662													0	0	0	0.010729	0	9	17										T	887189	C	T	887189	2	4	46	1	0	0	0	0	0	0	0	1	6195	813	29	1		1	GAK	4	887189	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	208606	887189	190267087	424	12121										
CRIPAK	285464	broad.mit.edu	37	chr4	1388306	1388306	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccctgcacctcttatgcatGagccctcgctttgtgccaat	7	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:1388306G>A	uc003gdf.2	+	1	2967	c.7G>A	c.(7-9)GAG>AAG	p.E3K		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	3					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			tcttatGCATGAGCCCTCGCT	0.338													0	0	0	0.01441	0	81	59										A	1388306	G	A	1388306	3	1	46	1	0	0	0	0	1	0	0	0	3877	1291	45	1	9	1	CRIPAK	4	1388306	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	501117	1388306	189765970	425	12122										
TACC3	10460	broad.mit.edu	37	chr4	1746259	1746259	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctagaacgaagagtcactGaagaagtgcgtggaggatta	13	6	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:1746259G>A	uc003gdo.2	+	14	2346	c.2238G>A	c.(2236-2238)CTG>CTA	p.L746L	TACC3_uc003gdp.2_Silent_p.L386L|TACC3_uc010ica.2_Silent_p.L167L	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	746	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AAGAGTCACTGAAGAAGTGCG	0.607													0	0	0	0.006214	0	9	55										A	1746259	G	A	1746259	2	1	46	1	0	0	0	0	0	0	0	1	15500	1277	45	1		1	TACC3	4	1746259	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	357953	1746259	189408017	426	12123										
TNIP2	79155	broad.mit.edu	37	chr4	2746669	2746669	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacttggcattgaggtcttCaacctgaagaggtggagccg	13	10	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:2746669C>T	uc003gfg.2	-	4	748	c.661G>A	c.(661-663)GAA>AAA	p.E221K	TNIP2_uc003gff.2_Missense_Mutation_p.E114K|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	221	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGAGGTCTTCAACCTGAAGA	0.582													0	0	0	0.004482	0	8	35										T	2746669	C	T	2746669	3	4	46	1	0	0	0	0	1	0	0	0	16312	835	29	1	640	1	TNIP2	4	2746669	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1000410	2746669	188407607	427	12124										
RGS12	6002	broad.mit.edu	37	chr4	3344756	3344756	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agatccaagagattcagtatCactcgctcccttgatgatct	7	11	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:3344756C>T	uc003ggw.2	+	3	2878	c.1974C>T	c.(1972-1974)ATC>ATT	p.I658I	RGS12_uc003ggu.2_Silent_p.I658I|RGS12_uc010ics.1_5'UTR|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Silent_p.I658I|RGS12_uc003ggy.1_Silent_p.I56I|RGS12_uc003ggx.1_Silent_p.I658I	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	658						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GATTCAGTATCACTCGCTCCC	0.433													0	0	0	0.004007	0	16	65										T	3344756	C	T	3344756	2	4	46	1	0	0	0	0	0	0	0	1	13295	816	29	1		1	RGS12	4	3344756	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	598087	3344756	187809520	428	12125										
RGS12	6002	broad.mit.edu	37	chr4	3424704	3424704	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagaaaagcgcaccttgtttCggtaagaggaagatcgctgt	12	7	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:3424704C>T	uc003ggw.2	+	12	4010	c.3106C>T	c.(3106-3108)CGG>TGG	p.R1036W	RGS12_uc003ggv.2_Missense_Mutation_p.R1036W|RGS12_uc003ggy.1_Missense_Mutation_p.R434W|RGS12_uc003ggz.2_Missense_Mutation_p.R388W|RGS12_uc010icu.1_Missense_Mutation_p.R235W|RGS12_uc011bvs.1_Missense_Mutation_p.R378W|RGS12_uc003gha.2_Missense_Mutation_p.R378W|RGS12_uc010icv.2_Missense_Mutation_p.R235W|RGS12_uc003ghb.2_Missense_Mutation_p.R235W	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1036	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CACCTTGTTTCGGTAAGAGGA	0.582													0	0	0	0.00308	0	7	35										T	3424704	C	T	3424704	3	4	46	1	0	0	0	0	1	0	0	0	13295	898	31	1	3206	1	RGS12	4	3424704	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	79948	3424704	187729572	429	12126										
ZBTB49	166793	broad.mit.edu	37	chr4	4303908	4303908	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttctgagtctgtgtcacacAtttttaaaatcagccactgt	7	9	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:4303908A>T	uc003ghu.2	+	3	520	c.345A>T	c.(343-345)ACA>ACT	p.T115T	ZBTB49_uc003ghv.2_Intron|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TGTGTCACACATTTTTAAAAT	0.418													0	0	0	0.013114	0	47	143										T	4303908	A	T	4303908	2	4	46	1	0	0	0	0	0	0	0	1	17547	204	8	5		5	ZBTB49	4	4303908	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	879204	4303908	186850368	430	12127										
EVC2	132884	broad.mit.edu	37	chr4	5567045	5567045	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgcttatcagatctcctCgcagtttgccatctaaggct	7	13	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:5567045C>G	uc003gij.2	-	21	3653	c.3599G>C	c.(3598-3600)CGA>CCA	p.R1200P	EVC2_uc011bwb.1_Missense_Mutation_p.R640P|EVC2_uc003gik.2_Missense_Mutation_p.R1120P	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1200						integral to membrane				large_intestine(3)|ovary(2)	5						CAGATCTCCTCGCAGTTTGCC	0.493													0	0	0	0.004482	0	7	107										G	5567045	C	G	5567045	3	3	46	1	0	0	0	0	1	0	0	0	5286	884	31	1	335	1	EVC2	4	5567045	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1263137	5567045	185587231	431	12128										
EVC2	132884	broad.mit.edu	37	chr4	5578040	5578040	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacagtagagacctgcctttCagaatccacctccccaggtt	8	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:5578040C>T	uc003gij.2	-	18	3253	c.3199G>A	c.(3199-3201)GAA>AAA	p.E1067K	EVC2_uc011bwb.1_Missense_Mutation_p.E507K|EVC2_uc003gik.2_Missense_Mutation_p.E987K	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1067	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						ACCTGCCTTTCAGAATCCACC	0.617													0	0	0	0.010818	0	30	100										T	5578040	C	T	5578040	3	4	46	1	0	0	0	0	1	0	0	0	5286	835	29	1	747	1	EVC2	4	5578040	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	10995	5578040	185576236	432	12129										
CRMP1	1400	broad.mit.edu	37	chr4	5838496	5838496	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagatccagccttaccaccGccttgtcccagacgaccgtc	8	17	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:5838496G>A	uc003gip.2	-	11	1207	c.1106C>T	c.(1105-1107)GCG>GTG	p.A369V	CRMP1_uc003gin.1_Missense_Mutation_p.A281V|CRMP1_uc003giq.2_Missense_Mutation_p.A369V|CRMP1_uc003gir.2_Missense_Mutation_p.A364V|CRMP1_uc003gis.2_Missense_Mutation_p.A483V	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	369				Missing (in Ref. 6; AAK55500).	axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CCTTACCACCGCCTTGTCCCA	0.547													0	0	0	0.012213	0	29	65										A	5838496	G	A	5838496	3	1	46	1	0	0	0	0	1	0	0	0	3890	1087	38	2	632	2	CRMP1	4	5838496	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	260456	5838496	185315780	433	12130										
CCDC96	257236	broad.mit.edu	37	chr4	7044015	7044015	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctgctgctcctgcagcttCtggacctcctcggaccactc	9	17	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:7044015C>T	uc003gjv.2	-	1	714	c.651G>A	c.(649-651)CAG>CAA	p.Q217Q	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	217											0						CCTGCAGCTTCTGGACCTCCT	0.582													0	0	0	0.004289	0	36	22										T	7044015	C	T	7044015	2	4	46	1	0	0	0	0	0	0	0	1	2874	912	32	1		1	CCDC96	4	7044015	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1205519	7044015	184110261	434	12131										
CCDC96	257236	broad.mit.edu	37	chr4	7044026	7044026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcagcttctggacctcctCggaccactcgaggtcctcaa	9	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:7044026C>T	uc003gjv.2	-	1	703	c.640G>A	c.(640-642)GAG>AAG	p.E214K	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	214	Glu-rich.										0						TGGACCTCCTCGGACCACTCG	0.552													0	0	0	0.009535	0	30	21										T	7044026	C	T	7044026	3	4	46	1	0	0	0	0	1	0	0	0	2874	893	31	1	1031	1	CCDC96	4	7044026	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	11	7044026	184110250	435	12132										
SH3TC1	54436	broad.mit.edu	37	chr4	8237168	8237168	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcctttcaggtggcacaGaacgtggccctgtacacagg	12	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:8237168G>A	uc003gkv.3	+	15	3392	c.3291G>A	c.(3289-3291)CAG>CAA	p.Q1097Q	SH3TC1_uc003gkw.3_Silent_p.Q1021Q|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	1097							binding			large_intestine(2)|pancreas(1)	3						AGGTGGCACAGAACGTGGCCC	0.647													0	0	0	0.013726	0	34	32										A	8237168	G	A	8237168	2	1	46	1	0	0	0	0	0	0	0	1	14261	933	33	1		1	SH3TC1	4	8237168	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1193142	8237168	182917108	436	12133										
GPR125	166647	broad.mit.edu	37	chr4	22456499	22456499	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atatacttacagccgaaccaGattggtgagtcctcgaaata	8	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:22456499G>A	uc003gqm.1	-	4	728	c.463C>T	c.(463-465)CTG>TTG	p.L155L	GPR125_uc010ieo.1_Silent_p.L29L|GPR125_uc003gqo.2_Silent_p.L155L	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	155	Extracellular (Potential).|LRR 4.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				AGCCGAACCAGATTGGTGAGT	0.358													0	0	0	0.004482	0	9	60										A	22456499	G	A	22456499	2	1	46	1	0	0	0	0	0	0	0	1	6639	933	33	1		1	GPR125	4	22456499	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14219331	22456499	168697777	437	12134										
LGI2	55203	broad.mit.edu	37	chr4	25005688	25005688	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctttgagctgtctgcgatGacaaagaacgtctcgtcgtc	11	11	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:25005688G>C	uc003grf.2	-	8	1122	c.1023C>G	c.(1021-1023)GTC>GTG	p.V341V		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	341	EAR 3.					extracellular region					0		Breast(46;0.173)				TGTCTGCGATGACAAAGAACG	0.468													0	0	0	0.01441	0	70	54										C	25005688	G	C	25005688	2	2	46	1	0	0	0	0	0	0	0	1	8752	1277	45	1		1	LGI2	4	25005688	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2549189	25005688	166148588	438	12135										
LGI2	55203	broad.mit.edu	37	chr4	25005740	25005740	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcgatgtcattgggcttgGaaatgcgagagacctctatg	13	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:25005740G>A	uc003grf.2	-	8	1070	c.971C>T	c.(970-972)TCC>TTC	p.S324F		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	324	EAR 3.					extracellular region					0		Breast(46;0.173)				ATTGGGCTTGGAAATGCGAGA	0.473													0	0	0	0.01441	0	120	78										A	25005740	G	A	25005740	3	1	46	1	0	0	0	0	1	0	0	0	8752	1174	41	1	670	1	LGI2	4	25005740	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	52	25005740	166148536	439	12136										
SLC34A2	10568	broad.mit.edu	37	chr4	25664407	25664407	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactgatagatgagcccactGaggtggatgacccctggaac	12	11	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:25664407G>A	uc003grr.2	+	3	274	c.193G>A	c.(193-195)GAG>AAG	p.E65K	SLC34A2_uc003grs.2_Missense_Mutation_p.E64K|SLC34A2_uc010iev.2_Missense_Mutation_p.E64K	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	65	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TGAGCCCACTGAGGTGGATGA	0.517													0	0	0	0.01441	0	103	64										A	25664407	G	A	25664407	3	1	46	1	0	0	0	0	1	0	0	0	14568	1291	45	1	199	1	SLC34A2	4	25664407	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	658667	25664407	165489869	440	12137										
TBC1D19	55296	broad.mit.edu	37	chr4	26750122	26750122	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttatgggatagaatcctagGatacaactctctggaaattc	8	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:26750122G>A	uc003gsf.3	+	19	1679	c.1409G>A	c.(1408-1410)GGA>GAA	p.G470E	TBC1D19_uc010iew.2_Missense_Mutation_p.G470E|TBC1D19_uc011bxu.1_Missense_Mutation_p.G405E	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	470	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				AGAATCCTAGGATACAACTCT	0.383													0	0	0	0.01441	0	65	132										A	26750122	G	A	26750122	3	1	46	1	0	0	0	0	1	0	0	0	15604	1174	41	1	1483	1	TBC1D19	4	26750122	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1085715	26750122	164404154	441	12138										
WDR19	57728	broad.mit.edu	37	chr4	39271675	39271675	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagatcaaaattccctccgaGatggccaccaacctcatgat	6	13	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39271675G>C	uc003gtv.2	+	31	3592	c.3438G>C	c.(3436-3438)GAG>GAC	p.E1146D	WDR19_uc011byi.1_Missense_Mutation_p.E986D|WDR19_uc003gtw.1_Missense_Mutation_p.E743D	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1146					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TTCCCTCCGAGATGGCCACCA	0.463													0	0	0	0.006122	0	19	58										C	39271675	G	C	39271675	3	2	46	1	0	0	0	0	1	0	0	0	17276	933	33	1	3560	1	WDR19	4	39271675	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	12521553	39271675	151882601	442	12139										
WDR19	57728	broad.mit.edu	37	chr4	39278656	39278656	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaggagacccgatatatctGagatagaagaggccacgact	11	9	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39278656G>A	uc003gtv.2	+	34	3887	c.3733G>A	c.(3733-3735)GAG>AAG	p.E1245K	WDR19_uc011byi.1_Missense_Mutation_p.E1085K	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1245					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CGATATATCTGAGATAGAAGA	0.418													0	0	0	0.013726	0	31	94										A	39278656	G	A	39278656	3	1	46	1	0	0	0	0	1	0	0	0	17276	1291	45	1	3867	1	WDR19	4	39278656	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6981	39278656	151875620	443	12140										
KLB	152831	broad.mit.edu	37	chr4	39448203	39448203	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccgcggtgaaccgacaggcCctgaggtactacaggtgcgt	14	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39448203C>T	uc003gua.2	+	4	1954	c.1857C>T	c.(1855-1857)GCC>GCT	p.A619A	KLB_uc011byj.1_Silent_p.A610A	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	619	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						ACCGACAGGCCCTGAGGTACT	0.597													0	0	0	0.001855	0	13	52										T	39448203	C	T	39448203	2	4	46	1	0	0	0	0	0	0	0	1	8332	610	22	2		2	KLB	4	39448203	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	169547	39448203	151706073	444	12141										
PDS5A	23244	broad.mit.edu	37	chr4	39978093	39978093	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcatctcgtccgtggtgatCttgtcggtgatctcttttac	9	10	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39978093C>T	uc003guv.3	-	2	645	c.105G>A	c.(103-105)AAG>AAA	p.K35K	PDS5A_uc010ifo.2_5'UTR|PDS5A_uc003guw.3_Silent_p.K35K	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	35					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						CCGTGGTGATCTTGTCGGTGA	0.557											OREG0016159	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	64	84										T	39978093	C	T	39978093	2	4	46	1	0	0	0	0	0	0	0	1	11691	912	32	1		1	PDS5A	4	39978093	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	529890	39978093	151176183	445	12142										
N4BP2	55728	broad.mit.edu	37	chr4	40103906	40103906	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacctggattccttaatacaGaatgcttttgagaaattgaa	8	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40103906G>A	uc003guy.3	+	4	779	c.441G>A	c.(439-441)CAG>CAA	p.Q147Q	N4BP2_uc010ifq.2_Silent_p.Q67Q|N4BP2_uc010ifr.2_Silent_p.Q67Q	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	147	Potential.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CCTTAATACAGAATGCTTTTG	0.333													0	0	0	0.004656	0	27	87										A	40103906	G	A	40103906	2	1	46	1	0	0	0	0	0	0	0	1	10110	933	33	1		1	N4BP2	4	40103906	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	125813	40103906	151050370	446	12143										
N4BP2	55728	broad.mit.edu	37	chr4	40123254	40123254	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctttagagaattctaattctCctgtgccagagtttagccat	7	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40123254C>T	uc003guy.3	+	9	3861	c.3523C>T	c.(3523-3525)CCT>TCT	p.P1175S	N4BP2_uc010ifq.2_Missense_Mutation_p.P1095S|N4BP2_uc010ifr.2_Missense_Mutation_p.P1095S	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1175						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTCTAATTCTCCTGTGCCAGA	0.418													0	0	0	0.003271	0	36	82										T	40123254	C	T	40123254	3	4	46	1	0	0	0	0	1	0	0	0	10110	855	30	1	3549	1	N4BP2	4	40123254	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	19348	40123254	151031022	447	12144										
N4BP2	55728	broad.mit.edu	37	chr4	40144375	40144375	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccagactatgatgactacaGagcagaggctttccttcacc	8	13	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40144375G>A	uc003guy.3	+	15	5206	c.4868G>A	c.(4867-4869)AGA>AAA	p.R1623K	N4BP2_uc010ifq.2_Missense_Mutation_p.R1543K|N4BP2_uc010ifr.2_Missense_Mutation_p.R1526K	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1623						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GATGACTACAGAGCAGAGGCT	0.413													0	0	0	0.007291	0	28	91										A	40144375	G	A	40144375	3	1	46	1	0	0	0	0	1	0	0	0	10110	942	33	1	4918	1	N4BP2	4	40144375	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	21121	40144375	151009901	448	12145										
RHOH	399	broad.mit.edu	37	chr4	40245409	40245409	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcctgcgtcaatgccatgGaagggaagaaactggcccag	12	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40245409G>A	uc003guz.2	+	3	1127	c.403G>A	c.(403-405)GAA>AAA	p.E135K		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	135					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						CAATGCCATGGAAGGGAAGAA	0.612													0	0	0	0.004007	0	15	41										A	40245409	G	A	40245409	3	1	46	1	0	0	0	0	1	0	0	0	13340	1175	41	1	405	1	RHOH	4	40245409	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	101034	40245409	150908867	449	12146										
CHRNA9	55584	broad.mit.edu	37	chr4	40350954	40350954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtggtcctgcggtatgatGggctgatcacctgggatgca	15	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40350954G>A	uc003gva.1	+	4	437	c.421G>A	c.(421-423)GGG>AGG	p.G141R		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	141	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	GCGGTATGATGGGCTGATCAC	0.507													0	0	0	0.007291	0	29	117										A	40350954	G	A	40350954	3	1	46	1	0	0	0	0	1	0	0	0	3389	1348	47	2	435	2	CHRNA9	4	40350954	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	105545	40350954	150803322	450	12147										
GABRG1	2565	broad.mit.edu	37	chr4	46053535	46053535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttccatattccatcaaggctGcaaaaacaaaaatgaaacaa	4	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:46053535G>A	uc003gxb.2	-	8	1189	c.1037C>T	c.(1036-1038)GCA>GTA	p.A346V		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	346	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CATCAAGGCTGCAAAAACAAA	0.373													0	0	0	0.003163	0	16	43										A	46053535	G	A	46053535	3	1	46	1	0	0	0	0	1	0	0	0	6171	1319	46	2	368	2	GABRG1	4	46053535	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5702581	46053535	145100741	451	12148										
ATP10D	57205	broad.mit.edu	37	chr4	47565643	47565643	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaggagggagtccctgaatCtatagaagctcttcacaaag	11	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:47565643C>T	uc003gxk.1	+	15	2878	c.2714C>T	c.(2713-2715)TCT>TTT	p.S905F	ATP10D_uc003gxl.1_Missense_Mutation_p.S153F	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	905	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GTCCCTGAATCTATAGAAGCT	0.473													0	0	0	0.00245	0	15	50										T	47565643	C	T	47565643	3	4	46	1	0	0	0	0	1	0	0	0	1118	913	32	1	2768	1	ATP10D	4	47565643	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1512108	47565643	143588633	452	12149										
ATP10D	57205	broad.mit.edu	37	chr4	47578955	47578955	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcagagaccctcatgcaaCtgcctgaactttacagaagt	8	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:47578955C>G	uc003gxk.1	+	19	3696	c.3532C>G	c.(3532-3534)CTG>GTG	p.L1178V	ATP10D_uc003gxl.1_Missense_Mutation_p.L426V	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1178	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CCTCATGCAACTGCCTGAACT	0.438													0	0	0	0.00632	0	29	119										G	47578955	C	G	47578955	3	3	46	1	0	0	0	0	1	0	0	0	1118	564	20	4	3602	4	ATP10D	4	47578955	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	13312	47578955	143575321	453	12150										
SLAIN2	57606	broad.mit.edu	37	chr4	48422195	48422195	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccatctcctttggctcttCggcaaccagtgaaagcattt	7	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:48422195C>T	uc003gya.3	+	7	1558	c.1414C>T	c.(1414-1416)CGG>TGG	p.R472W		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	472						centrosome					0						TTTGGCTCTTCGGCAACCAGT	0.478													0	0	0	0.008291	0	10	39										T	48422195	C	T	48422195	3	4	46	1	0	0	0	0	1	0	0	0	14366	875	31	1	1440	1	SLAIN2	4	48422195	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	843240	48422195	142732081	454	12151										
FRYL	285527	broad.mit.edu	37	chr4	48525073	48525073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcccctttgtcaatactgtCcagtgagcgcctgcgaactc	9	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:48525073C>T	uc003gyh.1	-	54	7971	c.7366G>A	c.(7366-7368)GAC>AAC	p.D2456N	FRYL_uc003gyf.1_5'Flank|FRYL_uc003gyg.1_Missense_Mutation_p.D1152N|FRYL_uc003gyi.1_Missense_Mutation_p.D1344N|FRYL_uc003gyj.1_Missense_Mutation_p.D751N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2456					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TCAATACTGTCCAGTGAGCGC	0.483													0	0	0	0.007835	0	40	55										T	48525073	C	T	48525073	3	4	46	1	0	0	0	0	1	0	0	0	6064	855	30	1	1719	1	FRYL	4	48525073	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	102878	48525073	142629203	455	12152										
FRYL	285527	broad.mit.edu	37	chr4	48605373	48605373	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcatctccacaaaatttttCaaacagggaacattcacttc	4	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:48605373C>T	uc003gyh.1	-	12	1472	c.867G>A	c.(865-867)TTG>TTA	p.L289L	FRYL_uc003gyk.2_Silent_p.L289L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CAAAATTTTTCAAACAGGGAA	0.289													0	0	0	0.006999	0	41	63										T	48605373	C	T	48605373	2	4	46	1	0	0	0	0	0	0	0	1	6064	825	29	1		1	FRYL	4	48605373	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	80300	48605373	142548903	456	12153										
KIT	3815	broad.mit.edu	37	chr4	55524236	55524236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgttctgctcctactgcttCgcgtccagacaggtgggaca	12	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:55524236C>T	uc010igr.2	+	1	142	c.55C>T	c.(55-57)CGC>TGC	p.R19C	KIT_uc010igs.2_Missense_Mutation_p.R19C	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	19					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTACTGCTTCGCGTCCAGAC	0.667		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	0.013537	0	11	17										T	55524236	C	T	55524236	3	4	46	1	0	0	0	0	1	0	0	0	8329	884	31	1	57	1	KIT	4	55524236	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6918863	55524236	135630040	457	12154										
LPHN3	23284	broad.mit.edu	37	chr4	62813849	62813849	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaatttcaaccctaactgttCattttggagctactccaagc	5	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:62813849C>T	uc010ihh.2	+	14	2629	c.2456C>T	c.(2455-2457)TCA>TTA	p.S819L	LPHN3_uc003hcq.3_Missense_Mutation_p.S819L|LPHN3_uc003hct.2_Missense_Mutation_p.S212L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	806	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCTAACTGTTCATTTTGGAGC	0.383													0	0	0	0.00308	0	7	26										T	62813849	C	T	62813849	3	4	46	1	0	0	0	0	1	0	0	0	8917	838	29	1	2510	1	LPHN3	4	62813849	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7289613	62813849	128340427	458	12155										
TMPRSS11A	339967	broad.mit.edu	37	chr4	68784859	68784859	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgcagagcggtacttctCatggataataaatcttctga	9	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:68784859C>T	uc003hdr.1	-	8	914	c.793G>A	c.(793-795)GAG>AAG	p.E265K	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.E262K	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	265	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						CGGTACTTCTCATGGATAATA	0.408													0	0	0	0.01441	0	60	74										T	68784859	C	T	68784859	3	4	46	1	0	0	0	0	1	0	0	0	16236	835	29	1	484	1	TMPRSS11A	4	68784859	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5971010	68784859	122369417	459	12156										
AFM	173	broad.mit.edu	37	chr4	74350018	74350018	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgttcaggaagcaacctttGaagaaatggaaaagctggtg	12	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:74350018G>A	uc003hhb.2	+	3	212	c.181G>A	c.(181-183)GAA>AAA	p.E61K		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	61	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGCAACCTTTGAAGAAATGGA	0.403													0	0	0	0.00333	0	25	69										A	74350018	G	A	74350018	3	1	46	1	0	0	0	0	1	0	0	0	361	1291	45	1	191	1	AFM	4	74350018	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5565159	74350018	116804258	460	12157										
RCHY1	25898	broad.mit.edu	37	chr4	76434446	76434446	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactttaaagcgatctagttGatgatcttcattgttatcat	6	7	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76434446G>A	uc003hik.2	-	2	283	c.151C>T	c.(151-153)CAA>TAA	p.Q51*	RCHY1_uc003hij.2_Nonsense_Mutation_p.Q51*|RCHY1_uc003hil.2_Nonsense_Mutation_p.Q51*|RCHY1_uc010iip.2_Nonsense_Mutation_p.Q51*|RCHY1_uc010iiq.2_RNA|RCHY1_uc010iir.2_Intron	NM_015436	NP_056251	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain	51	CHY-type.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CGATCTAGTTGATGATCTTCA	0.348													0	0	0	0.008361	0	29	15										A	76434446	G	A	76434446	4	1	46	1	0	0	0	0	0	1	0	0	13177	1299	45	1	666	1	RCHY1	4	76434446	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2084428	76434446	114719830	461	12158										
PPEF2	5470	broad.mit.edu	37	chr4	76781894	76781894	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcattctgaggcatcgccctCtgggcaggatttctccacaa	10	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76781894C>T	uc003hix.2	-	17	2545	c.2188G>A	c.(2188-2190)GAG>AAG	p.E730K	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	730					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCATCGCCCTCTGGGCAGGAT	0.507													0	0	0	0.00278	0	24	48										T	76781894	C	T	76781894	3	4	46	1	0	0	0	0	1	0	0	0	12308	922	32	1	77	1	PPEF2	4	76781894	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	347448	76781894	114372382	462	12159										
PPEF2	5470	broad.mit.edu	37	chr4	76782018	76782018	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatctgtaatgtcgatattCatgtgagagctgaacagctt	9	7	3	2	rs148045586		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76782018C>T	uc003hix.2	-	17	2421	c.2064G>A	c.(2062-2064)ATG>ATA	p.M688I	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	688					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGTCGATATTCATGTGAGAGC	0.453													0	0	0	0.00333	0	25	84										T	76782018	C	T	76782018	3	4	46	1	0	0	0	0	1	0	0	0	12308	826	29	1	201	1	PPEF2	4	76782018	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	124	76782018	114372258	463	12160										
SDAD1	55153	broad.mit.edu	37	chr4	76895235	76895235	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctataggtgctcaccttggtGaccttagagaaacatgcagt	10	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76895235G>A	uc003hje.3	-	7	749	c.630C>T	c.(628-630)GTC>GTT	p.V210V	SDAD1_uc003hjf.3_Silent_p.V113V|SDAD1_uc011cbr.1_Silent_p.V173V	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	210					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCACCTTGGTGACCTTAGAGA	0.418													0	0	0	0.00333	0	24	65										A	76895235	G	A	76895235	2	1	46	1	0	0	0	0	0	0	0	1	13950	1277	45	1		1	SDAD1	4	76895235	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	113217	76895235	114259041	464	12161										
SCARB2	950	broad.mit.edu	37	chr4	77100813	77100813	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataggctttcaacatggcctCgatgatctccctgaggaagt	10	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:77100813C>T	uc003hju.1	-	4	808	c.469G>A	c.(469-471)GAG>AAG	p.E157K	SCARB2_uc011cbu.1_Intron	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	157	Lumenal (Potential).				cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			AACATGGCCTCGATGATCTCC	0.498											OREG0016231	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	136	113										T	77100813	C	T	77100813	3	4	46	1	0	0	0	0	1	0	0	0	13882	893	31	1	1003	1	SCARB2	4	77100813	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	205578	77100813	114053463	465	12162										
SHROOM3	57619	broad.mit.edu	37	chr4	77660886	77660886	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attgatgagaatgggaaccaGaatggatctggcaggcctgg	15	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:77660886G>A	uc011cbx.1	+	5	2513	c.1560G>A	c.(1558-1560)CAG>CAA	p.Q520Q	SHROOM3_uc011cbz.1_Silent_p.Q344Q|SHROOM3_uc003hkf.1_Silent_p.Q395Q|SHROOM3_uc003hkg.2_Silent_p.Q298Q	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	520					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			ATGGGAACCAGAATGGATCTG	0.532													0	0	0	0.01441	0	64	48										A	77660886	G	A	77660886	2	1	46	1	0	0	0	0	0	0	0	1	14295	933	33	1		1	SHROOM3	4	77660886	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	560073	77660886	113493390	466	12163										
PRDM8	56978	broad.mit.edu	37	chr4	81123465	81123465	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctccccagcccagagcctCagcagcggtagcggcagcgg	14	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:81123465C>T	uc010ijo.2	+	8	1688	c.849C>T	c.(847-849)CTC>CTT	p.L283L	PRDM8_uc003hmb.3_Silent_p.L283L|PRDM8_uc003hmc.3_Silent_p.L283L	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	283	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCCAGAGCCTCAgcagcggta	0.562											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	8										T	81123465	C	T	81123465	2	4	46	1	0	0	0	0	0	0	0	1	12462	813	29	1		1	PRDM8	4	81123465	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3462579	81123465	110030811	467	12164										
TMEM150C	441027	broad.mit.edu	37	chr4	83406710	83406710	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagcttctgacaggctttctGagaagcttaggaaattctcc	9	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:83406710G>A	uc003hmy.1	-	8	782	c.704C>T	c.(703-705)TCA>TTA	p.S235L	TMEM150C_uc011ccj.1_Missense_Mutation_p.S265L	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	235						integral to membrane				ovary(1)	1						CAGGCTTTCTGAGAAGCTTAG	0.493													0	0	0	0.004482	0	9	12										A	83406710	G	A	83406710	3	1	46	1	0	0	0	0	1	0	0	0	16066	1294	45	1	49	1	TMEM150C	4	83406710	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2283245	83406710	107747566	468	12165										
COPS4	51138	broad.mit.edu	37	chr4	83978470	83978477	+	Frame_Shift_Del	DEL	CAATGAGC	CAATGAGC	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attgaagctgcacaaaggtaCaatgagctctcttacaagac							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:83978470_83978477delCAATGAGC	uc003hoa.2	+	6	763_770	c.624_631delCAATGAGC	c.(622-633)TACAATGAGCTCfs	p.Y208fs	COPS4_uc003hob.2_Frame_Shift_Del_p.Y208fs|COPS4_uc010ijw.2_Frame_Shift_Del_p.Y208fs|COPS4_uc010ijx.2_Frame_Shift_Del_p.Y208fs	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	208_211	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				CACAAAGGTACAATGAGCTCTCTTACAA	0.365																		33	48	---	---								-	83978477	CAATGAGC	-	83978470	7	5	46	1	0	1	0	1	0	0	0	0	3735	489	17	0	646	0	COPS4	4	83978470	Frame_Shift_Del	DEL	CAATGAGC	TCGA-DK-A1AC-01A-11D-A13W-08	571760	83978470	107175806	469	12166										
WDFY3	23001	broad.mit.edu	37	chr4	85672802	85672802	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgattggctcctgttcatcCctgtgtctgctgcaaacgct	9	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:85672802C>G	uc003hpd.2	-	36	6215	c.5807G>C	c.(5806-5808)GGG>GCG	p.G1936A		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1936						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CCTGTTCATCCCTGTGTCTGC	0.443													0	0	0	0.007291	0	28	142										G	85672802	C	G	85672802	3	3	46	1	0	0	0	0	1	0	0	0	17267	623	22	4	4905	4	WDFY3	4	85672802	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1694332	85672802	105481474	470	12167										
PTPN13	5783	broad.mit.edu	37	chr4	87653921	87653921	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctttagctaccctcaaaggTaccaagacattttatattca	5	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:87653921T>C	uc003hpz.2	+	12	2338	c.1858_splice	c.e12+2	p.D620_splice	PTPN13_uc003hpy.2_Splice_Site_p.D620_splice|PTPN13_uc003hqa.2_Splice_Site_p.D620_splice|PTPN13_uc003hqb.2_Splice_Site_p.D620_splice	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CCCTCAAAGGTACCAAGACAT	0.358													0	0	0	0.00245	0	15	19										C	87653921	T	C	87653921	5	2	46	1	0	0	0	0	0	0	1	0	12782	1652	57	5	1902	5	PTPN13	4	87653921	Splice_Site	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1981119	87653921	103500355	471	12168										
BMPR1B	658	broad.mit.edu	37	chr4	96051059	96051059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcagatggtgaaacagattgGaaaaggtcgctatggggaag	15	4	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:96051059G>A	uc003htm.3	+	9	906	c.632G>A	c.(631-633)GGA>GAA	p.G211E	BMPR1B_uc010ilb.2_Missense_Mutation_p.G211E|BMPR1B_uc003htn.3_Missense_Mutation_p.G211E	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	211	ATP (By similarity).|Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		AAACAGATTGGAAAAGGTCGC	0.458													0	0	0	0.003163	0	14	27										A	96051059	G	A	96051059	3	1	46	1	0	0	0	0	1	0	0	0	1470	1174	41	1	654	1	BMPR1B	4	96051059	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8397138	96051059	95103217	472	12169										
UNC5C	8633	broad.mit.edu	37	chr4	96199421	96199421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttattcacctcagccactgGgatcccttcaggtggtcgac	10	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:96199421G>A	uc003htp.1	-	4	737	c.583C>T	c.(583-585)CCA>TCA	p.P195S	UNC5C_uc010ilc.1_Missense_Mutation_p.P195S|UNC5C_uc003htq.2_Missense_Mutation_p.P195S	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	195	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCAGCCACTGGGATCCCTTCA	0.453													0	0	0	0.00245	0	14	52										A	96199421	G	A	96199421	3	1	46	1	0	0	0	0	1	0	0	0	16990	1232	43	2	2264	2	UNC5C	4	96199421	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	148362	96199421	94954855	473	12170										
DAPP1	27071	broad.mit.edu	37	chr4	100756843	100756843	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcctctcaaatggatgtgaCggcagctaccttctgaggga	11	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:100756843C>T	uc003hvf.3	+	2	255	c.165C>T	c.(163-165)GAC>GAT	p.D55D	DAPP1_uc011cek.1_Silent_p.D55D|DAPP1_uc010ilh.2_Silent_p.D55D	NM_014395	NP_055210	Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and	55	SH2.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity				0				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		ATGGATGTGACGGCAGCTACC	0.547													0	0	0	0.013114	0	48	65										T	100756843	C	T	100756843	2	4	46	1	0	0	0	0	0	0	0	1	4239	535	19	2		2	DAPP1	4	100756843	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4557422	100756843	90397433	474	12171										
UBE2D3	7323	broad.mit.edu	37	chr4	103723730	103723730	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atacttgccttaggtggtttGaaggggtagtctgtaggaaa	14	4	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:103723730G>C	uc003hwk.2	-	5	647	c.186C>G	c.(184-186)TTC>TTG	p.F62L	UBE2D3_uc003hwi.2_Missense_Mutation_p.F62L|UBE2D3_uc003hwj.2_RNA|UBE2D3_uc003hwl.2_Missense_Mutation_p.F62L|UBE2D3_uc011cet.1_Missense_Mutation_p.F62L|UBE2D3_uc011ceu.1_Missense_Mutation_p.F62L|UBE2D3_uc003hwo.2_Missense_Mutation_p.F62L|UBE2D3_uc003hwp.2_Missense_Mutation_p.F62L|UBE2D3_uc003hwq.2_Missense_Mutation_p.F64L|UBE2D3_uc003hwr.2_Missense_Mutation_p.F62L	NM_181887	NP_871616	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3 isoform 1	62					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TAGGTGGTTTGAAGGGGTAGT	0.343													0	0	0	0.01441	0	50	70										C	103723730	G	C	103723730	3	2	46	1	0	0	0	0	1	0	0	0	16847	1281	45	1	326	1	UBE2D3	4	103723730	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2966887	103723730	87430546	475	12172										
TBCK	93627	broad.mit.edu	37	chr4	107154786	107154786	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgtctttatcaattgcatCgtacttggcatgaatagctc	8	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:107154786C>T	uc010ilv.2	-	16	1836	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	TBCK_uc003hyb.2_Missense_Mutation_p.D234N|TBCK_uc003hye.2_Missense_Mutation_p.D452N|TBCK_uc003hyc.2_Missense_Mutation_p.D428N|TBCK_uc003hyd.2_Missense_Mutation_p.D319N|TBCK_uc003hyf.2_Missense_Mutation_p.D491N	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	491	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TCAATTGCATCGTACTTGGCA	0.269													0	0	0	0.008871	0	17	21										T	107154786	C	T	107154786	3	4	46	1	0	0	0	0	1	0	0	0	15633	884	31	1	1254	1	TBCK	4	107154786	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3431056	107154786	83999490	476	12173										
DKK2	27123	broad.mit.edu	37	chr4	107956627	107956627	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggcgtctccccgcccagaGaggacttgatggagttgagt	14	11	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:107956627G>A	uc003hyi.2	-	1	827	c.122C>T	c.(121-123)TCT>TTT	p.S41F	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.S41F	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	41					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CCCGCCCAGAGAGGACTTGAT	0.612													0	0	0	0.01441	0	41	18										A	107956627	G	A	107956627	3	1	46	1	0	0	0	0	1	0	0	0	4545	942	33	1	673	1	DKK2	4	107956627	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	801841	107956627	83197649	477	12174										
SEC24B	10427	broad.mit.edu	37	chr4	110384687	110384687	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaccagcagcaaagtctttCaggatacagtactctaacgt	7	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:110384687C>T	uc003hzk.2	+	2	819	c.764C>T	c.(763-765)TCA>TTA	p.S255L	SEC24B_uc003hzl.2_Missense_Mutation_p.S255L|SEC24B_uc011cfp.1_Missense_Mutation_p.S286L|SEC24B_uc011cfq.1_Missense_Mutation_p.S255L|SEC24B_uc011cfr.1_Missense_Mutation_p.S255L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	255					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAAAGTCTTTCAGGATACAGT	0.473													0	0	0	0.01441	0	76	13										T	110384687	C	T	110384687	3	4	46	1	0	0	0	0	1	0	0	0	13995	838	29	1	770	1	SEC24B	4	110384687	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2428060	110384687	80769589	478	12175										
SEC24B	10427	broad.mit.edu	37	chr4	110460768	110460768	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcatttgattgaagaccgGacagaggctgcattttctta	10	8	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:110460768G>C	uc003hzk.2	+	24	3799	c.3744G>C	c.(3742-3744)CGG>CGC	p.R1248R	SEC24B_uc003hzl.2_Silent_p.R1213R|SEC24B_uc011cfp.1_Silent_p.R1278R|SEC24B_uc011cfq.1_Silent_p.R1247R|SEC24B_uc011cfr.1_Silent_p.R1212R	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1248					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TTGAAGACCGGACAGAGGCTG	0.328													0	0	0	0.010771	0	44	24										C	110460768	G	C	110460768	2	2	46	1	0	0	0	0	0	0	0	1	13995	1161	41	1		1	SEC24B	4	110460768	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	76081	110460768	80693508	479	12176										
CFI	3426	broad.mit.edu	37	chr4	110682771	110682771	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaaactggtctctaatcctCggcaatgcacatgtagacat	7	12	1	1	rs143366614		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:110682771C>T	uc003hzr.3	-	4	768	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	CFI_uc003hzq.2_5'UTR|CFI_uc011cft.1_Missense_Mutation_p.R187Q|CFI_uc003hzs.3_Missense_Mutation_p.R187Q	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	187	SRCR.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CTCTAATCCTCGGCAATGCAC	0.388													0	0	0	0.01441	0	111	23										T	110682771	C	T	110682771	3	4	46	1	0	0	0	0	1	0	0	0	3289	884	31	1	1231	1	CFI	4	110682771	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	222003	110682771	80471505	480	12177										
ANK2	287	broad.mit.edu	37	chr4	114232546	114232546	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atacagcttggagggaggacGatctgacaggtatctcataa	12	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:114232546G>A	uc003ibe.3	+	24	2784	c.2684G>A	c.(2683-2685)CGA>CAA	p.R895Q	ANK2_uc003ibd.3_Missense_Mutation_p.R874Q|ANK2_uc003ibf.3_Missense_Mutation_p.R895Q|ANK2_uc011cgc.1_Missense_Mutation_p.R104Q|ANK2_uc003ibc.2_Missense_Mutation_p.R871Q|ANK2_uc011cgb.1_Missense_Mutation_p.R910Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	895					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGGGAGGACGATCTGACAGG	0.388													0	0	0	0.006214	0	9	37										A	114232546	G	A	114232546	3	1	46	1	0	0	0	0	1	0	0	0	621	1058	37	1	2803	1	ANK2	4	114232546	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3549775	114232546	76921730	481	12178										
PDE5A	8654	broad.mit.edu	37	chr4	120549792	120549792	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctggggctgctgctgctgtCgctgctgcccgaagctgggg	18	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:120549792C>T	uc003idh.2	-	1	190	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	PDE5A_uc003idf.2_5'Flank|PDE5A_uc003idg.2_5'Flank|uc003idj.1_5'UTR	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	12	Poly-Gln.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	ctgctgctgtcgctgctgcCC	0.483											OREG0016307	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	24	9										T	120549792	C	T	120549792	3	4	46	1	0	0	0	0	1	0	0	0	11644	884	31	1	2706	1	PDE5A	4	120549792	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6317246	120549792	70604484	482	12179										
NAA15	80155	broad.mit.edu	37	chr4	140291390	140291390	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtctgacaaagagctaaaGaagctacgtaataaacaaag	8	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:140291390G>C	uc003ihu.1	+	15	2035	c.1779G>C	c.(1777-1779)AAG>AAC	p.K593N		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	593					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						AAGAGCTAAAGAAGCTACGTA	0.219													0	0	0	0.010504	0	18	2										C	140291390	G	C	140291390	3	2	46	1	0	0	0	0	1	0	0	0	10118	933	33	1	1837	1	NAA15	4	140291390	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	19741598	140291390	50862886	483	12180										
ZNF330	27309	broad.mit.edu	37	chr4	142155060	142155060	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagaaaggattcagatactGagtcatcagatttgtttact	9	6	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:142155060G>A	uc003iiq.3	+	10	1100	c.880G>A	c.(880-882)GAG>AAG	p.E294K	ZNF330_uc011chl.1_Missense_Mutation_p.E234K	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	294						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					TTCAGATACTGAGTCATCAGA	0.313													0	0	0	0.010504	0	20	43										A	142155060	G	A	142155060	3	1	46	1	0	0	0	0	1	0	0	0	17845	1291	45	1	914	1	ZNF330	4	142155060	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1863670	142155060	48999216	484	12181										
USP38	84640	broad.mit.edu	37	chr4	144109040	144109040	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcatattcctcttcagatGattacagttctcatcaggag	7	10	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:144109040G>C	uc003ijb.2	+	2	1278	c.744G>C	c.(742-744)ATG>ATC	p.M248I	USP38_uc003ija.3_Missense_Mutation_p.M248I|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	248					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					CTCTTCAGATGATTACAGTTC	0.398													0	0	0	0.006122	0	19	45										C	144109040	G	C	144109040	3	2	46	1	0	0	0	0	1	0	0	0	17066	1290	45	1	750	1	USP38	4	144109040	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1953980	144109040	47045236	485	12182										
HHIP	64399	broad.mit.edu	37	chr4	145567932	145567932	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacgaagggagcggagcaagGaggagaaggtgcctgaatgg	19	5	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:145567932G>T	uc003ijs.1	+	1	760	c.105G>T	c.(103-105)AGG>AGT	p.R35S	uc003ijq.1_5'Flank|HHIP_uc003ijr.1_Missense_Mutation_p.R35S	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	35	Arg-rich.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GCGGAGCAAGGAGGAGAAGGT	0.562													1	0	2.4624e-09	0.008871	2.55543e-09	21	64										T	145567932	G	T	145567932	3	4	46	1	0	0	0	0	1	0	0	0	7092	1165	41	3	107	3	HHIP	4	145567932	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1458892	145567932	45586344	486	12183										
OTUD4	54726	broad.mit.edu	37	chr4	146067481	146067481	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atagagtaaacgggattcttCtatagcttgcttctctctgc	8	9	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:146067481C>T	uc003ika.3	-	14	1303	c.1165G>A	c.(1165-1167)GAA>AAA	p.E389K	OTUD4_uc003ijz.3_Missense_Mutation_p.E388K	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	453							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CGGGATTCTTCTATAGCTTGC	0.408													0	0	0	0.01441	0	67	57										T	146067481	C	T	146067481	3	4	46	1	0	0	0	0	1	0	0	0	11314	922	32	1	2016	1	OTUD4	4	146067481	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	499549	146067481	45086795	487	12184										
FBXW7	55294	broad.mit.edu	37	chr4	153247165	153247165	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taagagatcttacctgtaatGaatagactctattagtatgc	7	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:153247165G>A	uc003ims.2	-	10	1786	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	FBXW7_uc011cii.1_Missense_Mutation_p.S546L|FBXW7_uc003imt.2_Missense_Mutation_p.S546L|FBXW7_uc011cih.1_Missense_Mutation_p.S370L|FBXW7_uc003imq.2_Missense_Mutation_p.S466L|FBXW7_uc003imr.2_Missense_Mutation_p.S428L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	546	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTGTAATGAATAGACTCT	0.398			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.01441	0	86	27										A	153247165	G	A	153247165	3	1	46	1	0	0	0	0	1	0	0	0	5769	1294	45	1	498	1	FBXW7	4	153247165	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7179684	153247165	37907111	488	12185										
KIAA0922	23240	broad.mit.edu	37	chr4	154525365	154525365	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgaaaaacacaattgttttCagtaatccttcttcagaatg	5	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:154525365C>T	uc003inm.3	+	25	3250	c.3198C>T	c.(3196-3198)TTC>TTT	p.F1066F	KIAA0922_uc010ipp.2_Silent_p.F1067F|KIAA0922_uc010ipq.2_Silent_p.F835F	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1066	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAATTGTTTTCAGTAATCCTT	0.358													0	0	0	0.00278	0	25	54										T	154525365	C	T	154525365	2	4	46	1	0	0	0	0	0	0	0	1	8201	825	29	1		1	KIAA0922	4	154525365	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1278200	154525365	36628911	489	12186										
KIAA0922	23240	broad.mit.edu	37	chr4	154542885	154542885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgcagtgactttgagaggtCtgagctgagcagtgacatca	14	7	2	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:154542885C>G	uc003inm.3	+	28	3792	c.3740C>G	c.(3739-3741)TCT>TGT	p.S1247C	KIAA0922_uc010ipp.2_Missense_Mutation_p.S1248C|KIAA0922_uc010ipq.2_Missense_Mutation_p.S1016C	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1247	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TTTGAGAGGTCTGAGCTGAGC	0.428													0	0	0	0.012319	0	21	40										G	154542885	C	G	154542885	3	3	46	1	0	0	0	0	1	0	0	0	8201	913	32	1	3853	1	KIAA0922	4	154542885	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	17520	154542885	36611391	490	12187										
NAF1	92345	broad.mit.edu	37	chr4	164087539	164087539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgagtccgaatccgagtccGaggtctccaaggagtccggc	13	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:164087539G>A	uc003iqj.2	-	1	535	c.341C>T	c.(340-342)TCG>TTG	p.S114L	NAF1_uc010iqw.1_Missense_Mutation_p.S114L|NAF1_uc003iqk.2_RNA	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	114	Ser-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				ATCCGAGTCCGAGGTCTCCAA	0.706													0	0	0	0.013537	0	12	10										A	164087539	G	A	164087539	3	1	46	1	0	0	0	0	1	0	0	0	10140	1059	37	1	1316	1	NAF1	4	164087539	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	9544654	164087539	27066737	491	12188										
DDX60L	91351	broad.mit.edu	37	chr4	169351708	169351708	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caatgactttcgtagagattGattctaacgatttcccataa	6	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:169351708G>A	uc003irq.3	-	13	1819	c.1598C>T	c.(1597-1599)TCA>TTA	p.S533L	DDX60L_uc003irr.1_Missense_Mutation_p.S533L|DDX60L_uc003irs.1_Missense_Mutation_p.S260L	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	533							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CGTAGAGATTGATTCTAACGA	0.373													0	0	0	0.000602	0	5	14										A	169351708	G	A	169351708	3	1	46	1	0	0	0	0	1	0	0	0	4379	1294	45	1	3626	1	DDX60L	4	169351708	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5264169	169351708	21802568	492	12189										
SLC9A3	6550	broad.mit.edu	37	chr5	475147	475147	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctgcgtgcgggccctctgCgaggggaccaccgtctcccc	13	17	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:475147C>T	uc003jbe.2	-	16	2464	c.2352G>A	c.(2350-2352)TCG>TCA	p.S784S	SLC9A3_uc011clx.1_Silent_p.S775S|LOC25845_uc003jbd.2_5'Flank|LOC25845_uc010itb.1_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	784	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GGGCCCTCTGCGAGGGGACCA	0.672													0	0	0	0.00308	0	7	11										T	475147	C	T	475147	2	4	46	1	0	0	0	0	0	0	0	1	14713	755	27	2		2	SLC9A3	5	475147	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		475147	180440113	493	12190										
SLC12A7	10723	broad.mit.edu	37	chr5	1081816	1081816	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accgagggcacacctttcttCtccacaaacgcccccgcgtg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1081816C>T	uc003jbu.2	-	9	1239	c.1173G>A	c.(1171-1173)GAG>GAA	p.E391E		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	391					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CACCTTTCTTCTCCACAAACG	0.652													0	0	0	0.008291	0	10	35										T	1081816	C	T	1081816	2	4	46	1	0	0	0	0	0	0	0	1	14388	912	32	1		1	SLC12A7	5	1081816	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	606669	1081816	179833444	494	12191	57	2								
SLC12A7	10723	broad.mit.edu	37	chr5	1081819	1081819	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagggcacacctttcttctcCacaaacgcccccgcgtgcgc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1081819C>T	uc003jbu.2	-	9	1236	c.1170G>A	c.(1168-1170)GTG>GTA	p.V390V		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	390					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CTTTCTTCTCCACAAACGCCC	0.652													0	0	0	0.006214	0	9	35										T	1081819	C	T	1081819	2	4	46	1	0	0	0	0	0	0	0	1	14388	581	21	2		2	SLC12A7	5	1081819	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3	1081819	179833441	495	12192	57	2								
SLC6A18	348932	broad.mit.edu	37	chr5	1239598	1239598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaacccccgggtgtggctgGacgcagccacccagatattc	12	14	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1239598G>A	uc003jby.1	+	6	889	c.766G>A	c.(766-768)GAC>AAC	p.D256N		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	256	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGTGTGGCTGGACGCAGCCAC	0.577													0	0	0	0.01441	0	60	62										A	1239598	G	A	1239598	3	1	46	1	0	0	0	0	1	0	0	0	14681	1174	41	1	788	1	SLC6A18	5	1239598	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	157779	1239598	179675662	496	12193										
SLC6A3	6531	broad.mit.edu	37	chr5	1420746	1420746	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctgatgccgtctatggctcCagggagggtgaccccacgca	13	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1420746C>T	uc003jck.2	-	6	986	c.865G>A	c.(865-867)GGA>AGA	p.G289R		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	289					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TCTATGGCTCCAGGGAGGGTG	0.597													0	0	0	0.007413	0	19	77										T	1420746	C	T	1420746	3	4	46	1	0	0	0	0	1	0	0	0	14685	603	21	2	1037	2	SLC6A3	5	1420746	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	181148	1420746	179494514	497	12194										
NSUN2	54888	broad.mit.edu	37	chr5	6604332	6604332	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtcaacagtatcttaacatCttccattgatacagtaataa	5	8	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:6604332C>T	uc003jdu.2	-	17	1941	c.1876G>A	c.(1876-1878)GAT>AAT	p.D626N	NSUN2_uc003jds.2_Missense_Mutation_p.D72N|NSUN2_uc003jdt.2_Missense_Mutation_p.D390N|NSUN2_uc011cmk.1_Missense_Mutation_p.D591N|NSUN2_uc003jdv.2_Missense_Mutation_p.D390N	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	626						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						ATCTTAACATCTTCCATTGAT	0.363													0	0	0	0.003954	0	27	56										T	6604332	C	T	6604332	3	4	46	1	0	0	0	0	1	0	0	0	10678	913	32	1	439	1	NSUN2	5	6604332	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5183586	6604332	174310928	498	12195										
MTRR	4552	broad.mit.edu	37	chr5	7870910	7870910	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttacatgccttgaagtgatGaggaggtttctgttactata	11	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:7870910G>A	uc003jed.2	+	2	114	c.84G>A	c.(82-84)ATG>ATA	p.M28I	FASTKD3_uc011cmp.1_5'Flank|FASTKD3_uc003jeb.2_5'Flank|FASTKD3_uc003jec.2_5'Flank|MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.M1I|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	28					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TTGAAGTGATGAGGAGGTTTC	0.403													0	0	0	0.01441	0	56	52										A	7870910	G	A	7870910	3	1	46	1	0	0	0	0	1	0	0	0	9961	1290	45	1	90	1	MTRR	5	7870910	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1266578	7870910	173044350	499	12196										
SEMA5A	9037	broad.mit.edu	37	chr5	9202334	9202334	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taaaatttccgatgtcataaGatgacacaaagtttggctct	7	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:9202334G>A	uc003jek.2	-	9	1377	c.665C>T	c.(664-666)TCT>TTT	p.S222F		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	222	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GATGTCATAAGATGACACAAA	0.418													0	0	0	0.003163	0	15	29										A	9202334	G	A	9202334	3	1	46	1	0	0	0	0	1	0	0	0	14037	942	33	1	2619	1	SEMA5A	5	9202334	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1331424	9202334	171712926	500	12197										
FAM134B	54463	broad.mit.edu	37	chr5	16475032	16475032	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctgggatgggggcagcctGagaaagtgcttgctgcacac	15	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:16475032G>C	uc003jfs.2	-	9	1350	c.1312C>G	c.(1312-1314)CAG>GAG	p.Q438E	FAM134B_uc003jfr.2_Missense_Mutation_p.Q297E	NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	438					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						GGGGCAGCCTGAGAAAGTGCT	0.498													0	0	0	0.007413	0	18	55										C	16475032	G	C	16475032	3	2	46	1	0	0	0	0	1	0	0	0	5446	1299	45	1	185	1	FAM134B	5	16475032	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7272698	16475032	164440228	501	12198										
MYO10	4651	broad.mit.edu	37	chr5	16680071	16680071	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttaccttgatatcttgaatCagctgctgggtgggggtgtc	13	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:16680071C>T	uc003jft.3	-	33	4995	c.4527G>A	c.(4525-4527)CTG>CTA	p.L1509L	MYO10_uc011cnb.1_Silent_p.L138L|MYO10_uc011cnc.1_Silent_p.L388L|MYO10_uc011cnd.1_Silent_p.L866L|MYO10_uc011cne.1_Silent_p.L866L|MYO10_uc010itx.2_Silent_p.L1131L	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1509					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TATCTTGAATCAGCTGCTGGG	0.537													0	0	0	0.001168	0	5	21										T	16680071	C	T	16680071	2	4	46	1	0	0	0	0	0	0	0	1	10062	813	29	1		1	MYO10	5	16680071	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	205039	16680071	164235189	502	12199										
PRDM9	56979	broad.mit.edu	37	chr5	23522739	23522739	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccagattgtgagatgtgtcaGaacttcttcattgacagctg	10	8	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:23522739G>C	uc003jgo.2	+	8	809	c.627G>C	c.(625-627)CAG>CAC	p.Q209H		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	209					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGATGTGTCAGAACTTCTTCA	0.488										HNSCC(3;0.000094)			0	0	0	0.006214	0	9	24										C	23522739	G	C	23522739	3	2	46	1	0	0	0	0	1	0	0	0	12463	933	33	1	653	1	PRDM9	5	23522739	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6842668	23522739	157392521	503	12200										
CDH6	1004	broad.mit.edu	37	chr5	31302360	31302360	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggctggatatgtttgatgtCatcaccgaccaggaaaccca	11	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:31302360C>T	uc003jhe.1	+	6	1280	c.954C>T	c.(952-954)GTC>GTT	p.V318V	CDH6_uc003jhd.1_Silent_p.V318V	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	318	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGTTTGATGTCATCACCGACC	0.453													0	0	0	0.008291	0	11	47										T	31302360	C	T	31302360	2	4	46	1	0	0	0	0	0	0	0	1	3114	813	29	1		1	CDH6	5	31302360	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7779621	31302360	149612900	504	12201										
ADAMTS12	81792	broad.mit.edu	37	chr5	33641932	33641932	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactcggggttgttgcagagCctctctgcgctctggactcc	12	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:33641932C>T	uc003jia.1	-	11	1864	c.1701G>A	c.(1699-1701)AGG>AGA	p.R567R	ADAMTS12_uc010iuq.1_Silent_p.R567R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	567	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGTTGCAGAGCCTCTCTGCGC	0.592										HNSCC(64;0.19)			0	0	0	0.010504	0	19	54										T	33641932	C	T	33641932	2	4	46	1	0	0	0	0	0	0	0	1	257	738	26	2		2	ADAMTS12	5	33641932	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2339572	33641932	147273328	505	12202										
CAPSL	133690	broad.mit.edu	37	chr5	35921175	35921175	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggccgtggtgagctttttCttggcctggatcgccatctc	13	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:35921175C>G	uc003jjt.1	-	2	143	c.48G>C	c.(46-48)AAG>AAC	p.K16N	CAPSL_uc003jju.1_Missense_Mutation_p.K16N	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	16						cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TGAGCTTTTTCTTGGCCTGGA	0.612													0	0	0	0.001855	0	14	35										G	35921175	C	G	35921175	3	3	46	1	0	0	0	0	1	0	0	0	2639	912	32	1	594	1	CAPSL	5	35921175	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2279243	35921175	144994085	506	12203										
EGFLAM	133584	broad.mit.edu	37	chr5	38464063	38464063	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agatgccgtggatgggaaaaAcatcaacacttgtggagcca	12	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:38464063A>C	uc003jlc.1	+	23	3353	c.3029A>C	c.(3028-3030)AAC>ACC	p.N1010T	EGFLAM_uc003jlb.1_Missense_Mutation_p.N1002T|EGFLAM_uc003jle.1_Missense_Mutation_p.N768T|EGFLAM_uc003jlf.1_Missense_Mutation_p.N368T|EGFLAM_uc003jlg.1_Missense_Mutation_p.N145T|EGFLAM_uc003jlh.1_Missense_Mutation_p.N92T	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	1010	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GATGGGAAAAACATCAACACT	0.532													0	0	0	0.006214	0	10	24										C	38464063	A	C	38464063	3	2	46	1	0	0	0	0	1	0	0	0	4966	43	2	5	3105	5	EGFLAM	5	38464063	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	2542888	38464063	142451197	507	12204										
OSMR	9180	broad.mit.edu	37	chr5	38904542	38904542	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcgcgagtacggtgtgctGatgccagccacttctggaaa	14	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:38904542G>C	uc003jln.1	+	9	1589	c.1222G>C	c.(1222-1224)GAT>CAT	p.D408H		NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	408	Fibronectin type-III 1.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACGGTGTGCTGATGCCAGCCA	0.478													0	0	0	0.00499	0	16	55										C	38904542	G	C	38904542	3	2	46	1	0	0	0	0	1	0	0	0	11292	1290	45	1	1290	1	OSMR	5	38904542	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	440479	38904542	142010718	508	12205										
RICTOR	253260	broad.mit.edu	37	chr5	38945050	38945050	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcttttggtgctgctagctGagccttcttgagacacccca	10	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:38945050G>A	uc003jlp.2	-	35	4778	c.4754C>T	c.(4753-4755)TCA>TTA	p.S1585L	RICTOR_uc003jlo.2_Missense_Mutation_p.S1609L|RICTOR_uc010ivf.2_Missense_Mutation_p.S1262L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1585					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GCTGCTAGCTGAGCCTTCTTG	0.403													0	0	0	0.00874	0	40	124										A	38945050	G	A	38945050	3	1	46	1	0	0	0	0	1	0	0	0	13358	1294	45	1	388	1	RICTOR	5	38945050	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	40508	38945050	141970210	509	12206										
CARD6	84674	broad.mit.edu	37	chr5	40853853	40853853	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaaattttccagagttgctCggggatgtcactcgaatgga	12	7	1	2	rs34452222		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:40853853C>T	uc003jmg.2	+	3	2494	c.2419C>T	c.(2419-2421)CGG>TGG	p.R807W		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	807					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CAGAGTTGCTCGGGGATGTCA	0.473													0	0	0	0.01441	0	87	300										T	40853853	C	T	40853853	3	4	46	1	0	0	0	0	1	0	0	0	2650	875	31	1	2429	1	CARD6	5	40853853	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1908803	40853853	140061407	510	12207										
HEATR7B2	133558	broad.mit.edu	37	chr5	40998246	40998246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actaatacacggatcttgacGaagtgcttggagtcctgaaa	10	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:40998246G>A	uc003jmj.3	-	42	5156	c.4666C>T	c.(4666-4668)CGT>TGT	p.R1556C	HEATR7B2_uc003jmi.3_Missense_Mutation_p.R1111C	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1556							binding			ovary(6)|central_nervous_system(2)	8						GGATCTTGACGAAGTGCTTGG	0.483													0	0	0	0.01441	0	58	159										A	40998246	G	A	40998246	3	1	46	1	0	0	0	0	1	0	0	0	7035	1058	37	1	95	1	HEATR7B2	5	40998246	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	144393	40998246	139917014	511	12208										
HEATR7B2	133558	broad.mit.edu	37	chr5	41009477	41009477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccactggaggctggcttttCagccagcgccttccacaatg	10	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:41009477C>T	uc003jmj.3	-	32	3815	c.3325G>A	c.(3325-3327)GAA>AAA	p.E1109K	HEATR7B2_uc003jmi.3_Missense_Mutation_p.E664K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1109							binding			ovary(6)|central_nervous_system(2)	8						GCTGGCTTTTCAGCCAGCGCC	0.498													0	0	0	0.008361	0	15	55										T	41009477	C	T	41009477	3	4	46	1	0	0	0	0	1	0	0	0	7035	835	29	1	1476	1	HEATR7B2	5	41009477	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	11231	41009477	139905783	512	12209										
HEATR7B2	133558	broad.mit.edu	37	chr5	41009499	41009499	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccagcgccttccacaatgtCtttgtgtccctagggtggca	11	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:41009499C>T	uc003jmj.3	-	32	3793	c.3303G>A	c.(3301-3303)AAG>AAA	p.K1101K	HEATR7B2_uc003jmi.3_Silent_p.K656K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1101							binding			ovary(6)|central_nervous_system(2)	8						TCCACAATGTCTTTGTGTCCC	0.473													0	0	0	0.00278	0	23	76										T	41009499	C	T	41009499	2	4	46	1	0	0	0	0	0	0	0	1	7035	912	32	1		1	HEATR7B2	5	41009499	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	22	41009499	139905761	513	12210										
PELO	53918	broad.mit.edu	37	chr5	52096666	52096666	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggtcatgcaggaaggcctCgcccatatctgcttagtcac	11	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:52096666C>T	uc003jos.2	+	2	1423	c.438C>T	c.(436-438)CTC>CTT	p.L146L	ITGA1_uc003jov.2_Intron|ITGA1_uc003jou.2_Intron|PELO_uc003jot.1_Intron	NM_015946	NP_057030	Q9BRX2	PELO_HUMAN	pelota homolog	146					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding				0		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				AGGAAGGCCTCGCCCATATCT	0.582													0	0	0	0.009096	0	4	16										T	52096666	C	T	52096666	2	4	46	1	0	0	0	0	0	0	0	1	11724	871	31	1		1	PELO	5	52096666	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	11087167	52096666	128818594	514	12211										
SNX18	112574	broad.mit.edu	37	chr5	53815651	53815651	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttcaaagagtacctttgatGacagtgctatcattttagag	9	6	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:53815651G>A	uc003jpj.3	+	1	2059	c.1869G>A	c.(1867-1869)ATG>ATA	p.M623I	SNX18_uc011cqg.1_Intron|SNX18_uc003jpi.3_Intron	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	623	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TACCTTTGATGACAGTGCTAT	0.413													0	0	0	0.003163	0	15	44										A	53815651	G	A	53815651	3	1	46	1	0	0	0	0	1	0	0	0	14889	1290	45	1	1871	1	SNX18	5	53815651	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1718985	53815651	127099609	515	12212										
DHX29	54505	broad.mit.edu	37	chr5	54573026	54573026	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtccacagtggcactcattaGaatcaagtgtagatcagaac	9	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:54573026G>T	uc003jpx.2	-	13	2314	c.2194C>A	c.(2194-2196)CTA>ATA	p.L732I	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	732	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GCACTCATTAGAATCAAGTGT	0.368													1	0	1.08611e-07	0.010729	1.12018e-07	11	67										T	54573026	G	T	54573026	3	4	46	1	0	0	0	0	1	0	0	0	4503	933	33	3	1975	3	DHX29	5	54573026	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	757375	54573026	126342234	516	12213										
CWC27	10283	broad.mit.edu	37	chr5	64267618	64267618	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaagcaacagtcaaagaaGggaacttcccgggaagatca	12	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:64267618G>A	uc003jtn.1	+	12	1350	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	CWC27_uc010iwt.1_Silent_p.K377K	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	377	Potential.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						AGTCAAAGAAGGGAACTTCCC	0.383													0	0	0	0.010729	0	11	40										A	64267618	G	A	64267618	2	1	46	1	0	0	0	0	0	0	0	1	4070	991	35	2		2	CWC27	5	64267618	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	9694592	64267618	116647642	517	12214										
PIK3R1	5295	broad.mit.edu	37	chr5	67593263	67593263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggacggcgaagtaaagcattGtgtcataaacaaaacagcaa	10	7	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:67593263G>A	uc003jva.2	+	16	2569	c.2009G>A	c.(2008-2010)TGT>TAT	p.C670Y	PIK3R1_uc003jvb.2_Missense_Mutation_p.C670Y|PIK3R1_uc003jvc.2_Missense_Mutation_p.C370Y|PIK3R1_uc003jvd.2_Missense_Mutation_p.C400Y|PIK3R1_uc003jve.2_Missense_Mutation_p.C349Y	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	670	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GTAAAGCATTGTGTCATAAAC	0.433			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			0	0	0	0.00623	0	40	114										A	67593263	G	A	67593263	3	1	46	1	0	0	0	0	1	0	0	0	11918	1377	48	2	2197	2	PIK3R1	5	67593263	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3325645	67593263	113321997	518	12215										
ENC1	8507	broad.mit.edu	37	chr5	73932241	73932241	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcagcgtaggaggacttgtGaaacagatagatgttaatgg	14	4	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:73932241G>A	uc003kdc.3	-	2	1201	c.70C>T	c.(70-72)CAC>TAC	p.H24Y	ENC1_uc011css.1_Intron	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	24					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GAGGACTTGTGAAACAGATAG	0.473													0	0	0	0.00245	0	13	30										A	73932241	G	A	73932241	3	1	46	1	0	0	0	0	1	0	0	0	5113	1290	45	1	1703	1	ENC1	5	73932241	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6338978	73932241	106983019	519	12216										
FAM169A	26049	broad.mit.edu	37	chr5	74101053	74101053	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtaccagtgtccaacaccttCaacttcccaaaggagttcat	6	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:74101053C>T	uc003kdm.2	-	7	770	c.727G>A	c.(727-729)GAA>AAA	p.E243K	FAM169A_uc010izm.2_Missense_Mutation_p.E183K|FAM169A_uc003kdl.2_Missense_Mutation_p.E61K	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	243											0						CCAACACCTTCAACTTCCCAA	0.383													0	0	0	0.014323	0	24	67										T	74101053	C	T	74101053	3	4	46	1	0	0	0	0	1	0	0	0	5487	835	29	1	1313	1	FAM169A	5	74101053	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	168812	74101053	106814207	520	12217										
VCAN	1462	broad.mit.edu	37	chr5	82815228	82815228	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aactgcatcacccagtttatCcaaagaaccacaaatggttt	5	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:82815228C>G	uc003kii.3	+	7	1459	c.1103C>G	c.(1102-1104)TCC>TGC	p.S368C	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.S368C|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	368	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCCAGTTTATCCAAAGAACCA	0.388													0	0	0	0.010771	0	42	89										G	82815228	C	G	82815228	3	3	46	1	0	0	0	0	1	0	0	0	17135	855	30	1	1125	1	VCAN	5	82815228	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	8714175	82815228	98100032	521	12218										
CCNH	902	broad.mit.edu	37	chr5	86700760	86700760	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagcatccgtcaatgcaattCtattaagaaagtcatcagct	6	9	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:86700760C>T	uc003kjb.2	-	5	822	c.590G>A	c.(589-591)AGA>AAA	p.R197K	CCNH_uc003kiy.1_Intron|CCNH_uc003kiz.1_Missense_Mutation_p.R144K|CCNH_uc003kja.2_Missense_Mutation_p.R144K	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	197					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		CAATGCAATTCTATTAAGAAA	0.408								Direct_reversal_of_damage|NER					0	0	0	0.004007	0	17	37										T	86700760	C	T	86700760	3	4	46	1	0	0	0	0	1	0	0	0	2925	913	32	1	401	1	CCNH	5	86700760	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3885532	86700760	94214500	522	12219										
CCNH	902	broad.mit.edu	37	chr5	86703827	86703827	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaagccctcaaatggtctgTaaggattgtggacaataagg	13	6	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:86703827T>G	uc003kjb.2	-	4	723	c.491A>C	c.(490-492)TAC>TCC	p.Y164S	CCNH_uc003kiy.1_RNA|CCNH_uc003kiz.1_Missense_Mutation_p.Y111S|CCNH_uc003kja.2_Missense_Mutation_p.Y111S	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	164					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		AAATGGTCTGTAAGGATTGTG	0.363								Direct_reversal_of_damage|NER					0	0	0	0.00632	0	27	48										G	86703827	T	G	86703827	3	3	46	1	0	0	0	0	1	0	0	0	2925	1638	57	5	504	5	CCNH	5	86703827	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	3067	86703827	94211433	523	12220										
FAM172A	83989	broad.mit.edu	37	chr5	92956830	92956830	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaagttagctcgtgacggtCggtgcctgcaaagaacaaca	13	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:92956830C>T	uc010jbd.2	-	11	1321	c.1114G>A	c.(1114-1116)GAC>AAC	p.D372N	FAM172A_uc011cuf.1_Missense_Mutation_p.D326N|FAM172A_uc011cug.1_Missense_Mutation_p.D262N|FAM172A_uc011cuh.1_Missense_Mutation_p.D225N|FAM172A_uc011cui.1_RNA|FAM172A_uc011cuj.1_Silent_p.P101P|MIR2277_hsa-mir-2277|MI0011284_5'Flank	NM_032042	NP_114431	Q8WUF8	F172A_HUMAN	hypothetical protein LOC83989 isoform 1	372						endoplasmic reticulum|extracellular region					0						TCGTGACGGTCGGTGCCTGCA	0.607													0	0	0	0.00308	0	8	20										T	92956830	C	T	92956830	3	4	46	1	0	0	0	0	1	0	0	0	5492	884	31	1	140	1	FAM172A	5	92956830	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6253003	92956830	87958430	524	12221										
MAN2A1	4124	broad.mit.edu	37	chr5	109202634	109202634	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcattcacctcccggcactCagaatataagtgagatcaac	7	12	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:109202634C>T	uc003kou.1	+	22	4333	c.3370C>T	c.(3370-3372)CAG>TAG	p.Q1124*		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	1124	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TCCCGGCACTCAGAATATAAG	0.388													0	0	0	0.010818	0	33	77										T	109202634	C	T	109202634	4	4	46	1	0	0	0	0	0	1	0	0	9214	827	29	1	3456	1	MAN2A1	5	109202634	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	16245804	109202634	71712626	525	12222										
APC	324	broad.mit.edu	37	chr5	112111406	112111406	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttcagaatctcactaaaaGaatagatagtcttcctttaa	4	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:112111406G>C	uc010jby.2	+	5	883	c.503G>C	c.(502-504)AGA>ACA	p.R168T	APC_uc011cvt.1_Missense_Mutation_p.R178T|APC_uc003kpz.3_Missense_Mutation_p.R168T|APC_uc003kpy.3_Missense_Mutation_p.R168T|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	168	Leu-rich.|Potential.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CTCACTAAAAGAATAGATAGT	0.289		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			0	0	0	0.007291	0	29	57										C	112111406	G	C	112111406	3	2	46	1	0	0	0	0	1	0	0	0	763	942	33	1	517	1	APC	5	112111406	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2908772	112111406	68803854	526	12223										
MCC	4163	broad.mit.edu	37	chr5	112418687	112418687	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagtgagtgggccaggtgttCagccacactgctggatacct	13	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:112418687C>T	uc003kqj.3	-	9	1614	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E552K|MCC_uc011cwb.1_Missense_Mutation_p.E362K|MCC_uc010jcd.1_Missense_Mutation_p.E324K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	362					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GCCAGGTGTTCAGCCACACTG	0.423													0	0	0	0.008871	0	20	47										T	112418687	C	T	112418687	3	4	46	1	0	0	0	0	1	0	0	0	9373	835	29	1	1441	1	MCC	5	112418687	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	307281	112418687	68496573	527	12224										
MCC	4163	broad.mit.edu	37	chr5	112458513	112458513	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgatcgcagttctgagtactCatcttcctccctgagaaaaa	7	11	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:112458513C>T	uc003kqj.3	-	4	855	c.325G>A	c.(325-327)GAG>AAG	p.E109K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E299K|MCC_uc011cwb.1_Missense_Mutation_p.E109K|MCC_uc010jcd.1_Missense_Mutation_p.E71K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	109					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TCTGAGTACTCATCTTCCTCC	0.463													0	0	0	0.00245	0	14	28										T	112458513	C	T	112458513	3	4	46	1	0	0	0	0	1	0	0	0	9373	835	29	1	2220	1	MCC	5	112458513	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	39826	112458513	68456747	528	12225										
FEM1C	56929	broad.mit.edu	37	chr5	114878661	114878661	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actcacctttgacactttttCtattaacatctgcccccttt	2	14	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:114878661C>G	uc003krb.1	-	2	1092	c.530G>C	c.(529-531)AGA>ACA	p.R177T		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	177	ANK 5.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		GACACTTTTTCTATTAACATC	0.363													0	0	0	0.005443	0	27	83										G	114878661	C	G	114878661	3	3	46	1	0	0	0	0	1	0	0	0	5811	913	32	1	1331	1	FEM1C	5	114878661	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2420148	114878661	66036599	529	12226										
FEM1C	56929	broad.mit.edu	37	chr5	114879143	114879143	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacaatttggtgagaagccgGagtttgccatcccgagctgc	12	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:114879143G>A	uc003krb.1	-	2	610	c.48C>T	c.(46-48)CTC>CTT	p.L16L		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	16	ANK 1.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		TGAGAAGCCGGAGTTTGCCAT	0.468													0	0	0	0.008361	0	31	30										A	114879143	G	A	114879143	2	1	46	1	0	0	0	0	0	0	0	1	5811	1161	41	1		1	FEM1C	5	114879143	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	482	114879143	66036117	530	12227										
DMXL1	1657	broad.mit.edu	37	chr5	118533494	118533494	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcatgcggttctaaaaactCttcaatgttgggaacaagtt	9	7	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:118533494C>T	uc003ksd.2	+	32	7769	c.7588C>T	c.(7588-7590)CTT>TTT	p.L2530F	DMXL1_uc010jcl.1_Missense_Mutation_p.L2530F	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2530										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TCTAAAAACTCTTCAATGTTG	0.403													0	0	0	0.008361	0	29	100										T	118533494	C	T	118533494	3	4	46	1	0	0	0	0	1	0	0	0	4594	913	32	1	7714	1	DMXL1	5	118533494	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3654351	118533494	62381766	531	12228										
DMXL1	1657	broad.mit.edu	37	chr5	118533569	118533569	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcaaaattatatcgcaagtCataccgccgaagagagtttg	8	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:118533569C>T	uc003ksd.2	+	32	7844	c.7663C>T	c.(7663-7665)CAT>TAT	p.H2555Y	DMXL1_uc010jcl.1_Missense_Mutation_p.H2555Y	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2555										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATCGCAAGTCATACCGCCGA	0.428													0	0	0	0.009535	0	30	117										T	118533569	C	T	118533569	3	4	46	1	0	0	0	0	1	0	0	0	4594	826	29	1	7789	1	DMXL1	5	118533569	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	75	118533569	62381691	532	12229										
SNCAIP	9627	broad.mit.edu	37	chr5	121758693	121758693	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccactgaaacatcagccagaGactctggagaacaatgaaag	9	10	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:121758693G>A	uc003ksw.1	+	4	467	c.261G>A	c.(259-261)GAG>GAA	p.E87E	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Silent_p.E87E|SNCAIP_uc003ksx.1_Silent_p.E134E|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Silent_p.E87E	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	87					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ATCAGCCAGAGACTCTGGAGA	0.507													0	0	0	0.00499	0	17	35										A	121758693	G	A	121758693	2	1	46	1	0	0	0	0	0	0	0	1	14841	933	33	1		1	SNCAIP	5	121758693	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3225124	121758693	59156567	533	12230										
ZNF608	57507	broad.mit.edu	37	chr5	124036770	124036770	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtcccaggttcacagggccCaagacactctggctctgtca	11	14	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:124036770C>G	uc003ktq.1	-	2	1222	c.1099G>C	c.(1099-1101)GGG>CGG	p.G367R	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Missense_Mutation_p.G367R|ZNF608_uc003ktt.1_Missense_Mutation_p.G367R	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	367						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TCACAGGGCCCAAGACACTCT	0.453													0	0	0	0.004007	0	15	66										G	124036770	C	G	124036770	3	3	46	1	0	0	0	0	1	0	0	0	18031	594	21	4	3471	4	ZNF608	5	124036770	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2278077	124036770	56878490	534	12231										
ZNF608	57507	broad.mit.edu	37	chr5	124036909	124036909	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagggtagaatctgaggcgtGagactgctggaaatcggcgg	18	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:124036909G>A	uc003ktq.1	-	2	1083	c.960C>T	c.(958-960)CTC>CTT	p.L320L	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Silent_p.L320L|ZNF608_uc003ktt.1_Silent_p.L320L	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	320						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TCTGAGGCGTGAGACTGCTGG	0.512													0	0	0	0.010504	0	14	50										A	124036909	G	A	124036909	2	1	46	1	0	0	0	0	0	0	0	1	18031	1277	45	1		1	ZNF608	5	124036909	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	139	124036909	56878351	535	12232										
ZNF608	57507	broad.mit.edu	37	chr5	124080028	124080028	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgccattctggtggccctGaagcaggtcgtgcttgtcct	12	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:124080028G>A	uc003ktq.1	-	1	778	c.655C>T	c.(655-657)CAG>TAG	p.Q219*	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Nonsense_Mutation_p.Q219*|ZNF608_uc003ktt.1_Nonsense_Mutation_p.Q219*	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	219						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGGTGGCCCTGAAGCAGGTCG	0.617													0	0	0	0.01441	0	41	29										A	124080028	G	A	124080028	4	1	46	1	0	0	0	0	0	1	0	0	18031	1299	45	1	3919	1	ZNF608	5	124080028	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	43119	124080028	56835232	536	12233										
FBN2	2201	broad.mit.edu	37	chr5	127647056	127647056	+	Frame_Shift_Del	DEL	A	A	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactcacactggaagctcccAaaagtgttgatgcagtttcc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:127647056delA	uc003kuu.2	-	39	5449	c.5010delT	c.(5008-5010)TTTfs	p.F1670fs		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1670	EGF-like 27; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGAAGCTCCCAAAAGTGTTGA	0.483																		12	44	---	---								-	127647056	A	-	127647056	7	5	46	1	0	1	0	1	0	0	0	0	5703	127	5	0	3836	0	FBN2	5	127647056	Frame_Shift_Del	DEL	A	TCGA-DK-A1AC-01A-11D-A13W-08	3567028	127647056	53268204	537	12234										
FNIP1	96459	broad.mit.edu	37	chr5	131039796	131039796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taatttgttcatgtggctttCaaagagaggaaaatgtgaaa	10	3	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:131039796C>G	uc003kvs.1	-	10	1220	c.1078G>C	c.(1078-1080)GAA>CAA	p.E360Q	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.E332Q|FNIP1_uc010jdm.1_Missense_Mutation_p.E315Q|FNIP1_uc003kvu.2_Missense_Mutation_p.E360Q	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	360					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ATGTGGCTTTCAAAGAGAGGA	0.274													0	0	0	0.00245	0	14	55										G	131039796	C	G	131039796	3	3	46	1	0	0	0	0	1	0	0	0	5975	835	29	1	2458	1	FNIP1	5	131039796	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3392740	131039796	49875464	538	12235										
LEAP2	116842	broad.mit.edu	37	chr5	132209663	132209663	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagatggctccccaataccaGaagtgagttcggcaaagaga	11	9	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:132209663G>C	uc003kyc.2	+	2	108	c.79G>C	c.(79-81)GAA>CAA	p.E27Q	LEAP2_uc003kyb.1_Missense_Mutation_p.E27Q	NM_052971	NP_443203	Q969E1	LEAP2_HUMAN	liver-expressed antimicrobial peptide 2	27					defense response to bacterium	extracellular region					0		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCAATACCAGAAGTGAGTTC	0.512													0	0	0	0.003271	0	34	20										C	132209663	G	C	132209663	3	2	46	1	0	0	0	0	1	0	0	0	8711	943	33	1	85	1	LEAP2	5	132209663	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1169867	132209663	48705597	539	12236										
FSTL4	23105	broad.mit.edu	37	chr5	132534795	132534795	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctctgggcccttcatacctCacccacccacaccactgtgg	7	19	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:132534795C>T	uc003kyn.1	-	16	2739	c.2521G>A	c.(2521-2523)GAG>AAG	p.E841K	FSTL4_uc003kym.1_Missense_Mutation_p.E490K	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	841						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTCATACCTCACCCACCCAC	0.557													0	0	0	0.00308	0	7	21										T	132534795	C	T	132534795	3	4	46	1	0	0	0	0	1	0	0	0	6079	835	29	1	11	1	FSTL4	5	132534795	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	325132	132534795	48380465	540	12237										
FSTL4	23105	broad.mit.edu	37	chr5	132535121	132535121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggccaagtctgagatgcccGagtttatttgcaggtcatac	11	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:132535121G>A	uc003kyn.1	-	16	2413	c.2195C>T	c.(2194-2196)TCG>TTG	p.S732L	FSTL4_uc003kym.1_Missense_Mutation_p.S381L	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	732						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGATGCCCGAGTTTATTTG	0.572													0	0	0	0.004007	0	17	37										A	132535121	G	A	132535121	3	1	46	1	0	0	0	0	1	0	0	0	6079	1059	37	1	337	1	FSTL4	5	132535121	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	326	132535121	48380139	541	12238										
C5orf15	56951	broad.mit.edu	37	chr5	133295697	133295697	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacggttgggctcggtgaatCagtccgtgatacaactgaaa	12	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:133295697C>T	uc003kyo.2	-	2	285	c.154G>A	c.(154-156)GAT>AAT	p.D52N		NM_020199	NP_064584	Q8NC54	KCT2_HUMAN	keratinocytes associated transmembrane protein 2	52	Extracellular (Potential).					integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			CTCGGTGAATCAGTCCGTGAT	0.368													0	0	0	0.010504	0	19	32										T	133295697	C	T	133295697	3	4	46	1	0	0	0	0	1	0	0	0	2283	826	29	1	651	1	C5orf15	5	133295697	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	760576	133295697	47619563	542	12239										
TIFAB	497189	broad.mit.edu	37	chr5	134785161	134785161	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgctaccctgaaccaggggGaggctgcccctgggagatgc	15	13	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:134785161G>C	uc003law.3	-	2	670	c.469C>G	c.(469-471)CCC>GCC	p.P157A	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	157											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GAACCAGGGGGAGGCTGCCCC	0.582													0	0	0	0.00499	0	18	68										C	134785161	G	C	134785161	3	2	46	1	0	0	0	0	1	0	0	0	15892	1174	41	1	20	1	TIFAB	5	134785161	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1489464	134785161	46130099	543	12240										
MATR3	9782	broad.mit.edu	37	chr5	138661216	138661216	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaacacagaaccaggtgctGaatcttctgagaacgctgat	9	9	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:138661216G>T	uc003ldu.2	+	16	2663	c.2236G>T	c.(2236-2238)GAA>TAA	p.E746*	MATR3_uc003ldt.2_Nonsense_Mutation_p.E408*|MATR3_uc003ldw.2_Nonsense_Mutation_p.E794*|MATR3_uc003ldx.2_Nonsense_Mutation_p.E746*|MATR3_uc010jfc.2_Nonsense_Mutation_p.E746*|MATR3_uc011czb.1_Nonsense_Mutation_p.E458*|MATR3_uc003ldz.2_Nonsense_Mutation_p.E746*|MATR3_uc003lea.2_Nonsense_Mutation_p.E746*|MATR3_uc003leb.2_Nonsense_Mutation_p.E408*|MATR3_uc003lec.2_Nonsense_Mutation_p.E423*	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	746						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACCAGGTGCTGAATCTTCTGA	0.408													1	0	1.33834e-09	0.007413	1.38957e-09	18	55										T	138661216	G	T	138661216	4	4	46	1	0	0	0	0	0	1	0	0	9337	1291	45	3	2282	3	MATR3	5	138661216	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3876055	138661216	42254044	544	12241										
MATR3	9782	broad.mit.edu	37	chr5	138665072	138665072	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagaagaacgcagacagaaGaaggaaacttaagatgtgca	12	6	0	6			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:138665072G>C	uc003ldu.2	+	18	2959	c.2532G>C	c.(2530-2532)AAG>AAC	p.K844N	MATR3_uc003ldt.2_Missense_Mutation_p.K506N|MATR3_uc003ldw.2_Missense_Mutation_p.K892N|MATR3_uc003ldx.2_Missense_Mutation_p.K844N|MATR3_uc010jfc.2_3'UTR|MATR3_uc011czb.1_Missense_Mutation_p.K556N|MATR3_uc003ldz.2_Missense_Mutation_p.K844N|MATR3_uc003lea.2_Missense_Mutation_p.K844N|MATR3_uc003leb.2_Missense_Mutation_p.K506N|MATR3_uc003lec.2_Missense_Mutation_p.K521N	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	844						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GCAGACAGAAGAAGGAAACTT	0.289													0	0	0	0.004007	0	17	88										C	138665072	G	C	138665072	3	2	46	1	0	0	0	0	1	0	0	0	9337	933	33	1	2586	1	MATR3	5	138665072	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3856	138665072	42250188	545	12242										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139905595	139905595	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttcagtggagcaagaagttCccatagaacctcctagtgca	9	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:139905595C>T	uc003lfs.1	+	26	4631	c.4507C>T	c.(4507-4509)CCC>TCC	p.P1503S	ANKHD1_uc003lfr.2_Missense_Mutation_p.P1503S|ANKHD1_uc003lfu.1_Missense_Mutation_p.P983S|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.P242S|ANKHD1_uc003lfw.2_Missense_Mutation_p.P141S|ANKHD1_uc010jfl.2_5'UTR|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1503						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGAAGTTCCCATAGAACC	0.358													0	0	0	0.00278	0	24	76										T	139905595	C	T	139905595	3	4	46	1	0	0	0	0	1	0	0	0	629	855	30	1	4609	1	ANKHD1-EIF4EBP3	5	139905595	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1240523	139905595	41009665	546	12243										
PCDHA9	9752	broad.mit.edu	37	chr5	140230192	140230192	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgtacctgatcatcgccatCtgcgcggtgtctagcctgtt	11	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140230192C>G	uc003lhu.2	+	1	2836	c.2112C>G	c.(2110-2112)ATC>ATG	p.I704M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.I704M	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	704	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCGCCATCTGCGCGGTGT	0.662													0	0	0	0.009535	0	31	31										G	140230192	C	G	140230192	3	3	46	1	0	0	0	0	1	0	0	0	11531	903	32	1	2114	1	PCDHA9	5	140230192	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	324597	140230192	40685068	547	12244										
PCDHAC1	56135	broad.mit.edu	37	chr5	140308755	140308755	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttatctctatcgggcctctCtgggacttggttctgataat	9	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140308755C>T	uc003lih.2	+	1	2454	c.2278C>T	c.(2278-2280)CTG>TTG	p.L760L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Silent_p.L760L	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGGCCTCTCTGGGACTTGG	0.463													0	0	0	0.01441	0	54	66										T	140308755	C	T	140308755	2	4	46	1	0	0	0	0	0	0	0	1	11532	912	32	1		1	PCDHAC1	5	140308755	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	78563	140308755	40606505	548	12245										
PCDHB1	29930	broad.mit.edu	37	chr5	140431478	140431478	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacaaggagccgcttttaaaGattccggagagcaccccttt	9	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140431478G>A	uc003lik.1	+	1	500	c.423G>A	c.(421-423)AAG>AAA	p.K141K		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	141	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTTTTAAAGATTCCGGAGA	0.547													0	0	0	0.00308	0	8	41										A	140431478	G	A	140431478	2	1	46	1	0	0	0	0	0	0	0	1	11534	933	33	1		1	PCDHB1	5	140431478	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	122723	140431478	40483782	549	12246										
PCDHB4	56131	broad.mit.edu	37	chr5	140502976	140502976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccgcgagaacaacagccccGccctgcacatcggcagtgtc	10	17	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140502976G>A	uc003lip.1	+	1	1396	c.1396G>A	c.(1396-1398)GCC>ACC	p.A466T		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	466	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAACAGCCCCGCCCTGCACAT	0.647													0	0	0	0.004289	0	26	44										A	140502976	G	A	140502976	3	1	46	1	0	0	0	0	1	0	0	0	11544	1087	38	2	1398	2	PCDHB4	5	140502976	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	71498	140502976	40412284	550	12247										
PCDHB11	56125	broad.mit.edu	37	chr5	140579748	140579748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgatcactctcccatcttctCggaaaaacaaatgctcctag	5	13	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140579748C>T	uc003liy.2	+	1	401	c.401C>T	c.(400-402)TCG>TTG	p.S134L	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	134	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCATCTTCTCGGAAAAACAA	0.428													0	0	0	0.009718	0	43	151										T	140579748	C	T	140579748	3	4	46	1	0	0	0	0	1	0	0	0	11536	893	31	1	403	1	PCDHB11	5	140579748	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	76772	140579748	40335512	551	12248										
PCDHGA5	56110	broad.mit.edu	37	chr5	140744168	140744168	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggtcaccgcgggcaggataGaccgggaggagctctgcgct	17	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140744168G>A	uc003lju.1	+	1	271	c.271G>A	c.(271-273)GAC>AAC	p.D91N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.D91N	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCAGGATAGACCGGGAGGA	0.542													0	0	0	0.00278	0	20	33										A	140744168	G	A	140744168	3	1	46	1	0	0	0	0	1	0	0	0	11557	942	33	1	273	1	PCDHGA5	5	140744168	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	164420	140744168	40171092	552	12249										
PCDHGB6	56100	broad.mit.edu	37	chr5	140788029	140788029	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcggggacttacttgtgaAgaaccgaatagaccgtgagc	14	8	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140788029A>C	uc003lkj.1	+	1	260	c.260A>C	c.(259-261)AAG>ACG	p.K87T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.K87T	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	87	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTACTTGTGAAGAACCGAATA	0.488													0	0	0	0.00632	0	28	78										C	140788029	A	C	140788029	3	2	46	1	0	0	0	0	1	0	0	0	11567	72	3	5	262	5	PCDHGB6	5	140788029	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	43861	140788029	40127231	553	12250										
YIPF5	81555	broad.mit.edu	37	chr5	143549462	143549462	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataggactgctgtgactgatCatcgatgctgtaacttgtct	10	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:143549462C>T	uc003lnk.3	-	2	499	c.58G>A	c.(58-60)GAT>AAT	p.D20N	KCTD16_uc003lnm.1_5'Flank|YIPF5_uc003lnl.3_Missense_Mutation_p.D20N|YIPF5_uc010jgl.2_Intron	NM_001024947	NP_001020118	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	20	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				ovary(1)|skin(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TGTGACTGATCATCGATGCTG	0.358													0	0	0	0.01441	0	82	55										T	143549462	C	T	143549462	3	4	46	1	0	0	0	0	1	0	0	0	17478	826	29	1	735	1	YIPF5	5	143549462	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2761433	143549462	37365798	554	12251										
GRXCR2	643226	broad.mit.edu	37	chr5	145252343	145252343	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttccccagacccataaacAccatccattgtttcaagaga	4	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:145252343A>G	uc003lns.1	-	1	189	c.189T>C	c.(187-189)GGT>GGC	p.G63G		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	63											0						ACCCATAAACACCATCCATTG	0.498													0	0	0	0.01441	0	49	83										G	145252343	A	G	145252343	2	3	46	1	0	0	0	0	0	0	0	1	6813	146	6	5		5	GRXCR2	5	145252343	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1702881	145252343	35662917	555	12252										
STK32A	202374	broad.mit.edu	37	chr5	146763487	146763487	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaacaaaagacaaccaaatCtagccttggaacaaaccaaa	4	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:146763487C>A	uc010jgn.1	+	13	1412	c.1132C>A	c.(1132-1134)CTA>ATA	p.L378I	STK32A_uc011dbw.1_Missense_Mutation_p.L378I	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	378							ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACCAAATCTAGCCTTGGA	0.338													1	0	8.00594e-06	0.007413	8.1909e-06	17	26										A	146763487	C	A	146763487	3	1	46	1	0	0	0	0	1	0	0	0	15296	912	32	3	1211	3	STK32A	5	146763487	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1511144	146763487	34151773	556	12253										
GRPEL2	134266	broad.mit.edu	37	chr5	148730750	148730750	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttggggtgcagcctggcaccGtggcattagtaagacaagat	14	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:148730750G>A	uc003lqj.2	+	4	709	c.583G>A	c.(583-585)GTG>ATG	p.V195M	GRPEL2_uc011dca.1_3'UTR	NM_152407	NP_689620	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial precursor	195					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTGGCACCGTGGCATTAGT	0.532													0	0	0	0.01441	0	55	59										A	148730750	G	A	148730750	3	1	46	1	0	0	0	0	1	0	0	0	6807	1145	40	2	597	2	GRPEL2	5	148730750	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1967263	148730750	32184510	557	12254										
SLC36A1	206358	broad.mit.edu	37	chr5	150847396	150847396	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggtgctgctggttttcatCaggaacctccgagccctgtc	11	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:150847396C>A	uc003luc.2	+	7	850	c.633C>A	c.(631-633)ATC>ATA	p.I211I	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Silent_p.I211I|SLC36A1_uc010jhw.1_Silent_p.I211I	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	211	Helical; Name=4; (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TGGTTTTCATCAGGAACCTCC	0.522													1	0	2.39187e-15	0.008871	2.51349e-15	18	56										A	150847396	C	A	150847396	2	1	46	1	0	0	0	0	0	0	0	1	14593	816	29	3		3	SLC36A1	5	150847396	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2116646	150847396	30067864	558	12255										
CCNJL	79616	broad.mit.edu	37	chr5	159682612	159682612	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggaatagcttgagatcctCtgcaggtctctggtccagta	12	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:159682612C>T	uc003lyb.1	-	6	1083	c.831G>A	c.(829-831)CAG>CAA	p.Q277Q	CCNJL_uc011dee.1_Silent_p.Q229Q|CCNJL_uc003lyc.1_RNA|CCNJL_uc011def.1_Silent_p.Q229Q	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	277						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGAGATCCTCTGCAGGTCTC	0.507													0	0	0	0.01441	0	76	78										T	159682612	C	T	159682612	2	4	46	1	0	0	0	0	0	0	0	1	2929	912	32	1		1	CCNJL	5	159682612	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	8835216	159682612	21232648	559	12256										
ODZ2	57451	broad.mit.edu	37	chr5	167655045	167655045	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggacgctgcaacatctccctGcctatggagaatggcttaaa	10	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:167655045G>A	uc010jjd.2	+	25	5403	c.5403G>A	c.(5401-5403)CTG>CTA	p.L1801L	ODZ2_uc003lzr.3_Silent_p.L1571L|ODZ2_uc003lzt.3_Silent_p.L1174L|ODZ2_uc010jje.2_Silent_p.L1065L	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACATCTCCCTGCCTATGGAGA	0.527													0	0	0	0.010729	0	10	4										A	167655045	G	A	167655045	2	1	46	1	0	0	0	0	0	0	0	1	10835	1306	46	2		2	ODZ2	5	167655045	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7972433	167655045	13260215	560	12257										
DOCK2	1794	broad.mit.edu	37	chr5	169122855	169122855	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataaaatttacttgatttgtCaaatagtccgggtcggcaag	9	6	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:169122855C>T	uc003maf.2	+	10	972	c.892C>T	c.(892-894)CAA>TAA	p.Q298*	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	298					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTGATTTGTCAAATAGTCCG	0.473													0	0	0	0.01441	0	52	45										T	169122855	C	T	169122855	4	4	46	1	0	0	0	0	0	1	0	0	4687	827	29	1	930	1	DOCK2	5	169122855	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1467810	169122855	11792405	561	12258										
KCNIP1	30820	broad.mit.edu	37	chr5	170159845	170159845	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccatctatgacatgatgggGaaatacacatatcctgtgct	9	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:170159845G>A	uc003mas.2	+	7	1039	c.510G>A	c.(508-510)GGG>GGA	p.G170G	KCNIP1_uc003map.2_Silent_p.G168G|KCNIP1_uc003mat.2_Silent_p.G159G|KCNIP1_uc010jjp.2_Silent_p.G131G|KCNIP1_uc010jjq.2_Silent_p.G184G	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	170					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATGATGGGGAAATACACAT	0.493													0	0	0	0.010504	0	19	44										A	170159845	G	A	170159845	2	1	46	1	0	0	0	0	0	0	0	1	8039	1161	41	1		1	KCNIP1	5	170159845	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1036990	170159845	10755415	562	12259										
STK10	6793	broad.mit.edu	37	chr5	171517361	171517361	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggtttttttgtacagtttCgggtcctggccagggaaaac	13	7	0	0	rs148086376		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:171517361C>T	uc003mbo.1	-	10	1860	c.1560G>A	c.(1558-1560)CCG>CCA	p.P520P		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	520							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTACAGTTTCGGGTCCTGGC	0.532													0	0	0	0.01441	0	44	129										T	171517361	C	T	171517361	2	4	46	1	0	0	0	0	0	0	0	1	15285	871	31	1		1	STK10	5	171517361	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1357516	171517361	9397899	563	12260										
CPLX2	10814	broad.mit.edu	37	chr5	175306917	175306917	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctggagcagccctgcgagGggagcctgacccggcccaag	15	16	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:175306917G>C	uc003mde.1	+	5	620	c.274G>C	c.(274-276)GGG>CGG	p.G92R	CPLX2_uc003mdf.1_Missense_Mutation_p.G92R	NM_006650	NP_006641	Q6PUV4	CPLX2_HUMAN	complexin 2	92	Interaction with the SNARE complex (By similarity).				mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				ovary(1)	1	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCCCTGCGAGGGGAGCCTGAC	0.642													0	0	0	0.001168	0	5	17										C	175306917	G	C	175306917	3	2	46	1	0	0	0	0	1	0	0	0	3805	1232	43	4	284	4	CPLX2	5	175306917	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3789556	175306917	5608343	564	12261										
HIGD2A	192286	broad.mit.edu	37	chr5	175816403	175816403	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggcaacagccagcgctctCagctcatgatgcgcacccgg	13	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:175816403C>T	uc003meg.2	+	2	263	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	NOP16_uc003med.2_5'Flank|NOP16_uc003mee.2_5'Flank|NOP16_uc011dfl.1_5'Flank|NOP16_uc011dfm.1_5'Flank	NM_138820	NP_620175	Q9BW72	HIG2A_HUMAN	HIG1 hypoxia inducible domain family, member 2A	76	Extracellular (Potential).|HIG1.					integral to membrane					0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		CCAGCGCTCTCAGCTCATGAT	0.637													0	0	0	0.01441	0	45	69										T	175816403	C	T	175816403	4	4	46	1	0	0	0	0	0	1	0	0	7109	827	29	1	232	1	HIGD2A	5	175816403	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	509486	175816403	5098857	565	12262										
HK3	3101	broad.mit.edu	37	chr5	176309065	176309065	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgttgatgcacatgcggcctGagtccccaggcacgcccgcc	12	16	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176309065G>C	uc003mfa.2	-	16	2209	c.2117C>G	c.(2116-2118)TCA>TGA	p.S706*	HK3_uc003mez.2_Nonsense_Mutation_p.S262*	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	706	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGCGGCCTGAGTCCCCAGG	0.617													0	0	0	0.004007	0	16	23										C	176309065	G	C	176309065	4	2	46	1	0	0	0	0	0	1	0	0	7192	1294	45	1	670	1	HK3	5	176309065	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	492662	176309065	4606195	566	12263										
NSD1	64324	broad.mit.edu	37	chr5	176562564	176562564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaatggctttctgcactttGagaattttacttgtgtggac	10	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176562564G>C	uc003mfr.3	+	2	598	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	NSD1_uc003mft.3_Intron|NSD1_uc003mfs.1_Missense_Mutation_p.E154Q|NSD1_uc011dfx.1_Intron|NSD1_uc003mfp.2_Missense_Mutation_p.E154Q|NSD1_uc003mfq.2_Missense_Mutation_p.E154Q	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	154					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCTGCACTTTGAGAATTTTAC	0.423			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.010504	0	22	107										C	176562564	G	C	176562564	3	2	46	1	0	0	0	0	1	0	0	0	10669	1291	45	1	462	1	NSD1	5	176562564	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	253499	176562564	4352696	567	12264										
NSD1	64324	broad.mit.edu	37	chr5	176721473	176721473	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gataaatccataggtgctgcCagcccaaggccccagtcact	9	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176721473C>G	uc003mfr.3	+	23	7242	c.7104C>G	c.(7102-7104)GCC>GCG	p.A2368A	NSD1_uc003mft.3_Silent_p.A2099A|NSD1_uc011dfx.1_Silent_p.A2016A	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2368	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TAGGTGCTGCCAGCCCAAGGC	0.587			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.010729	0	9	56										G	176721473	C	G	176721473	2	3	46	1	0	0	0	0	0	0	0	1	10669	581	21	4		4	NSD1	5	176721473	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	158909	176721473	4193787	568	12265										
GRK6	2870	broad.mit.edu	37	chr5	176867977	176867977	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgggctggatggctcagttCccccagacctggactggaag	14	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176867977C>T	uc011dfz.1	+	15	1760	c.1600C>T	c.(1600-1602)CCC>TCC	p.P534S	GRK6_uc003mgq.2_Missense_Mutation_p.P534S|GRK6_uc003mgs.1_Missense_Mutation_p.P504S|uc003mgt.2_Intron	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	534					regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCTCAGTTCCCCCAGACCT	0.612													0	0	0	0.008291	0	11	37										T	176867977	C	T	176867977	3	4	46	1	0	0	0	0	1	0	0	0	6793	855	30	1	1658	1	GRK6	5	176867977	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	146504	176867977	4047283	569	12266										
ZFP2	80108	broad.mit.edu	37	chr5	178359071	178359071	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatgtggaaaagccttcagtCaaagcatgcatcttattgta	8	7	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:178359071C>T	uc003mjn.1	+	5	1266	c.757C>T	c.(757-759)CAA>TAA	p.Q253*	ZFP2_uc010jky.2_Nonsense_Mutation_p.Q253*|ZFP2_uc010jkx.1_Nonsense_Mutation_p.Q253*	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	253	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		AGCCTTCAGTCAAAGCATGCA	0.383													0	0	0	0.008871	0	18	72										T	178359071	C	T	178359071	4	4	46	1	0	0	0	0	0	1	0	0	17638	827	29	1	759	1	ZFP2	5	178359071	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1491094	178359071	2556189	570	12267										
ADAMTS2	9509	broad.mit.edu	37	chr5	178554964	178554964	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcgagaccccctcacctccGccacagggcttggagcacgg	11	17	1	1	rs145016043	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:178554964G>A	uc003mjw.2	-	17	2613	c.2613C>T	c.(2611-2613)GGC>GGT	p.G871G		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	871	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCTCACCTCCGCCACAGGGCT	0.627													0	0	0	0.00632	0	27	75										A	178554964	G	A	178554964	2	1	46	1	0	0	0	0	0	0	0	1	265	1074	38	2		2	ADAMTS2	5	178554964	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	195893	178554964	2360296	571	12268										
SQSTM1	8878	broad.mit.edu	37	chr5	179251010	179251010	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccagactacgacttgtgtAgcgtctgcgagggaaagggc	15	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:179251010A>T	uc003mkw.3	+	3	549	c.454A>T	c.(454-456)AGC>TGC	p.S152C	SQSTM1_uc011dgr.1_Missense_Mutation_p.S68C|SQSTM1_uc011dgs.1_Missense_Mutation_p.S68C|SQSTM1_uc003mkv.3_Missense_Mutation_p.S152C|SQSTM1_uc003mkx.2_Missense_Mutation_p.S68C	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	152	ZZ-type.|Interaction with GABRR3 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGACTTGTGTAGCGTCTGCGA	0.627									Paget_Disease_of_Bone				0	0	0	0.007413	0	18	41										T	179251010	A	T	179251010	3	4	46	1	0	0	0	0	1	0	0	0	15129	420	15	5	464	5	SQSTM1	5	179251010	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	696046	179251010	1664250	572	12269										
GFPT2	9945	broad.mit.edu	37	chr5	179763570	179763570	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtgattattcccatcgatCgccacacctgtgatgtagac	8	12	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:179763570C>T	uc003mlw.1	-	3	221	c.123G>A	c.(121-123)GCG>GCA	p.A41A		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	41	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	TCCCATCGATCGCCACACCTG	0.478													0	0	0	0.01441	0	166	125										T	179763570	C	T	179763570	2	4	46	1	0	0	0	0	0	0	0	1	6346	871	31	1		1	GFPT2	5	179763570	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	512560	179763570	1151690	573	12270										
OR2V2	285659	broad.mit.edu	37	chr5	180582627	180582627	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctagggactgtgctgcaaAtgcactctgctcaggcctgg	12	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:180582627A>G	uc011dhj.1	+	1	685	c.685A>G	c.(685-687)ATG>GTG	p.M229V		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTGCTGCAAATGCACTCTGC	0.527													0	0	0	0.012213	0	34	158										G	180582627	A	G	180582627	3	3	46	1	0	0	0	0	1	0	0	0	11031	101	4	5	687	5	OR2V2	5	180582627	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	819057	180582627	332633	574	12271										
RIOK1	83732	broad.mit.edu	37	chr6	7398940	7398940	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttttggttaggtatcgcatCaaagataaggcagacagagc	11	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:7398940C>G	uc003mxn.2	+	5	621	c.447C>G	c.(445-447)ATC>ATG	p.I149M	RIOK1_uc003mxm.1_Missense_Mutation_p.I45M	NM_031480	NP_113668	Q9BRS2	RIOK1_HUMAN	RIO kinase 1 isoform 1	149							ATP binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|skin(1)	4	Ovarian(93;0.0418)					GGTATCGCATCAAAGATAAGG	0.313													0	0	0	0.00278	0	22	30										G	7398940	C	G	7398940	3	3	46	1	0	0	0	0	1	0	0	0	13377	816	29	1	465	1	RIOK1	6	7398940	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		7398940	163716127	575	12272										
DSP	1832	broad.mit.edu	37	chr6	7583091	7583091	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaattcagaatgacctgaatCagtggaagactcaatattcc	7	8	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:7583091C>T	uc003mxp.1	+	24	5875	c.5596C>T	c.(5596-5598)CAG>TAG	p.Q1866*	DSP_uc003mxq.1_Nonsense_Mutation_p.Q1267*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1866	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGACCTGAATCAGTGGAAGAC	0.453													0	0	0	0.012319	0	22	37										T	7583091	C	T	7583091	4	4	46	1	0	0	0	0	0	1	0	0	4781	827	29	1	5690	1	DSP	6	7583091	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	184151	7583091	163531976	576	12273										
SYCP2L	221711	broad.mit.edu	37	chr6	10907799	10907799	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaccagcaggttgctatttCtgaagcgctgtgtagactga	12	8	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:10907799C>G	uc003mzo.2	+	10	997	c.701C>G	c.(700-702)TCT>TGT	p.S234C	SYCP2L_uc011din.1_Missense_Mutation_p.S75C|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	234						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GTTGCTATTTCTGAAGCGCTG	0.348													0	0	0	0.00623	0	38	45										G	10907799	C	G	10907799	3	3	46	1	0	0	0	0	1	0	0	0	15430	913	32	1	739	1	SYCP2L	6	10907799	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3324708	10907799	160207268	577	12274										
HIVEP1	3096	broad.mit.edu	37	chr6	12123091	12123091	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcgctgggtcctccggcatCtgggaacagacgccccagat	13	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:12123091C>T	uc003nac.2	+	4	3242	c.3063C>T	c.(3061-3063)ATC>ATT	p.I1021I	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1021					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CCTCCGGCATCTGGGAACAGA	0.488													0	0	0	0.00874	0	35	894										T	12123091	C	T	12123091	2	4	46	1	0	0	0	0	0	0	0	1	7186	903	32	1		1	HIVEP1	6	12123091	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1215292	12123091	158991976	578	12275										
KIF13A	63971	broad.mit.edu	37	chr6	17804706	17804706	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgattttcttgggcttcataGaaagggtcacctcgttttcc	9	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:17804706G>A	uc003ncg.3	-	20	2445	c.2340C>T	c.(2338-2340)TTC>TTT	p.F780F	KIF13A_uc003ncf.2_Silent_p.F780F|KIF13A_uc003nch.3_Silent_p.F780F|KIF13A_uc003nci.3_Silent_p.F780F	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	780					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GGGCTTCATAGAAAGGGTCAC	0.423													0	0	0	0.012319	0	21	6										A	17804706	G	A	17804706	2	1	46	1	0	0	0	0	0	0	0	1	8274	933	33	1		1	KIF13A	6	17804706	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5681615	17804706	153310361	579	12276										
CDKAL1	54901	broad.mit.edu	37	chr6	21065357	21065357	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggattttcaagaaacagtGaaacttgttgaagagtacaa	9	5	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:21065357G>A	uc003ndc.1	+	12	1308	c.1134G>A	c.(1132-1134)GTG>GTA	p.V378V	CDKAL1_uc003ndd.1_Silent_p.V378V|CDKAL1_uc003nde.1_Silent_p.V308V|CDKAL1_uc003ndf.1_5'UTR	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	378					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			AAGAAACAGTGAAACTTGTTG	0.368													0	0	0	0.014323	0	22	504										A	21065357	G	A	21065357	2	1	46	1	0	0	0	0	0	0	0	1	3152	1277	45	1		1	CDKAL1	6	21065357	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3260651	21065357	150049710	580	12277										
CDKAL1	54901	broad.mit.edu	37	chr6	21231097	21231097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggacttcagaaatgggcttGggaaccagctgagttcagga	14	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:21231097G>A	uc003ndc.1	+	16	1741	c.1567G>A	c.(1567-1569)GGG>AGG	p.G523R	CDKAL1_uc003ndd.1_Missense_Mutation_p.G523R|CDKAL1_uc003nde.1_Missense_Mutation_p.G432R|CDKAL1_uc003ndf.1_Missense_Mutation_p.G36R|CDKAL1_uc003ndg.2_RNA	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	523					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			AAATGGGCTTGGGAACCAGCT	0.463													0	0	0	0.010504	0	20	327										A	21231097	G	A	21231097	3	1	46	1	0	0	0	0	1	0	0	0	3152	1348	47	2	1621	2	CDKAL1	6	21231097	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	165740	21231097	149883970	581	12278										
HIST1H3C	8352	broad.mit.edu	37	chr6	26045930	26045930	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcgctgcaggaggcttgtGaggcctacctggtgggactc	17	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26045930G>A	uc003nfv.2	+	1	292	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GGAGGCTTGTGAGGCCTACCT	0.577													0	0	0	0.00245	0	15	27										A	26045930	G	A	26045930	3	1	46	1	0	0	0	0	1	0	0	0	7157	1291	45	1	294	1	HIST1H3C	6	26045930	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4814833	26045930	145069137	582	12279										
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158404	26158404	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctattaacgctacgatgcctGaacctaccaagtctgctcct	6	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26158404G>A	uc003ngr.2	+	1	56	c.7G>A	c.(7-9)GAA>AAA	p.E3K	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.E3K	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	3					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						TACGATGCCTGAACCTACCAA	0.507													0	0	0	0.003163	0	15	51										A	26158404	G	A	26158404	3	1	46	1	0	0	0	0	1	0	0	0	7143	1291	45	1	9	1	HIST1H2BD	6	26158404	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	112474	26158404	144956663	583	12280										
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158626	26158626	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcttcgagcgcatcgcaggcGaggcttcccgcctggcgcat	13	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26158626G>A	uc003ngr.2	+	1	278	c.229G>A	c.(229-231)GAG>AAG	p.E77K	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.E77K	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	77					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						CATCGCAGGCGAGGCTTCCCG	0.612													0	0	0	0.01441	0	45	94										A	26158626	G	A	26158626	3	1	46	1	0	0	0	0	1	0	0	0	7143	1059	37	1	231	1	HIST1H2BD	6	26158626	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	222	26158626	144956441	584	12281										
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184336	26184336	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgtgcgcctgctgcttcccGgggagctggccaagcacgct	14	16	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26184336G>C	uc003ngt.2	+	1	313	c.313G>C	c.(313-315)GGG>CGG	p.G105R		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	105					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						GCTGCTTCCCGGGGAGCTGGC	0.617													0	0	0	0.006122	0	18	52										C	26184336	G	C	26184336	3	2	46	1	0	0	0	0	1	0	0	0	7144	1116	39	4	315	4	HIST1H2BE	6	26184336	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	25710	26184336	144930731	585	12282										
HIST1H2AE	3012	broad.mit.edu	37	chr6	26217568	26217568	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgctgcctaagaagacggaGagccaccataaggccaaggg	13	10	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26217568G>A	uc003nha.1	+	1	421	c.366G>A	c.(364-366)GAG>GAA	p.E122E	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	122					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				AGAAGACGGAGAGCCACCATA	0.542													0	0	0	0.010729	0	8	21										A	26217568	G	A	26217568	2	1	46	1	0	0	0	0	0	0	0	1	7132	933	33	1		1	HIST1H2AE	6	26217568	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	33232	26217568	144897499	586	12283										
BTN3A2	11118	broad.mit.edu	37	chr6	26368410	26368410	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctcttgatatgcagcataGatgaaaatggcaagttccct	8	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26368410G>C	uc010jqh.1	+	3	260	c.1_splice	c.e3-1	p.M1_splice	BTN3A2_uc003nho.1_5'UTR|BTN3A2_uc003nhp.2_5'UTR|BTN3A2_uc011dkd.1_Intron|BTN3A2_uc011dke.1_Intron|BTN3A2_uc010jqi.1_5'UTR	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor							integral to membrane					0						ATGCAGCATAGATGAAAATGG	0.493													0	0	0	0.011902	0	36	57										C	26368410	G	C	26368410	5	2	46	1	0	0	0	0	0	0	1	0	1563	957	33	1	2	1	BTN3A2	6	26368410	Splice_Site	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	150842	26368410	144746657	587	12284										
HIST1H1B	3009	broad.mit.edu	37	chr6	27834692	27834692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttgctgctttgggcttagCggctttgggctttgccgcct	13	10	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:27834692C>T	uc003njx.2	-	1	668	c.616G>A	c.(616-618)GCT>ACT	p.A206T		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	206					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						TTGGGCTTAGCGGCTTTGGGC	0.552													0	0	0	0.010729	0	10	44										T	27834692	C	T	27834692	3	4	46	1	0	0	0	0	1	0	0	0	7123	768	27	2	68	2	HIST1H1B	6	27834692	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1466282	27834692	143280375	588	12285										
ZNF192	7745	broad.mit.edu	37	chr6	28120950	28120950	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggatgttatcaggggtcttGagcatgaagaagcccgagac	15	7	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:28120950G>C	uc003nkn.1	+	6	1076	c.892G>C	c.(892-894)GAG>CAG	p.E298Q	ZNF192_uc010jqx.1_Missense_Mutation_p.E298Q|ZNF192_uc010jqy.1_Missense_Mutation_p.E111Q|ZNF192_uc011dkz.1_Missense_Mutation_p.E111Q	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	298	KRAB.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CAGGGGTCTTGAGCATGAAGA	0.478													0	0	0	0.00499	0	18	52										C	28120950	G	C	28120950	3	2	46	1	0	0	0	0	1	0	0	0	17753	1291	45	1	910	1	ZNF192	6	28120950	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	286258	28120950	142994117	589	12286										
PPP1R10	5514	broad.mit.edu	37	chr6	30574287	30574287	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgggtgctgtggtgcgaaGagacttgggcttctccctct	14	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:30574287G>C	uc003nqn.1	-	8	1144	c.592C>G	c.(592-594)CTT>GTT	p.L198V	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	198	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GTGGTGCGAAGAGACTTGGGC	0.577													0	0	0	0.007413	0	16	72										C	30574287	G	C	30574287	3	2	46	1	0	0	0	0	1	0	0	0	12352	942	33	1	2282	1	PPP1R10	6	30574287	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2453337	30574287	140540780	590	12287										
C6orf136	221545	broad.mit.edu	37	chr6	30617717	30617717	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaacatctgtctgtcatgtAtgagagactgagacaagagg	13	6	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:30617717A>G	uc003nqw.3	+	2	648	c.455A>G	c.(454-456)TAT>TGT	p.Y152C	C6orf136_uc003nqx.3_Missense_Mutation_p.Y333C|C6orf136_uc011dmn.1_Intron	NM_001109938	NP_001103408	Q5SQH8	CF136_HUMAN	hypothetical protein LOC221545 isoform 1	152											0						TCTGTCATGTATGAGAGACTG	0.527													0	0	0	0.010504	0	20	53										G	30617717	A	G	30617717	3	3	46	1	0	0	0	0	1	0	0	0	2331	449	16	5	1004	5	C6orf136	6	30617717	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	43430	30617717	140497350	591	12288										
BAT2	7916	broad.mit.edu	37	chr6	31602048	31602062	+	In_Frame_Del	DEL	GGGCTCTAAGCCTGA	GGGCTCTAAGCCTGA	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcatagctctggattcttGggctctaagcctgagggccc					rs139245110		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:31602048_31602062delGGGCTCTAAGCCTGA	uc003nvb.3	+	19	5004_5018	c.4755_4769delGGGCTCTAAGCCTGA	c.(4753-4770)TTGGGCTCTAAGCCTGAG>TTG	p.GSKPE1586del	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_In_Frame_Del_p.GSKPE1586del	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1586_1590	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CTGGATTCTTGGGCTCTAAGCCTGAGGGCCCAGGC	0.512																		61	509	---	---								-	31602062	GGGCTCTAAGCCTGA	-	31602048	7	5	46	1	0	1	0	1	0	0	0	0	1319	1339	47	0	4825	0	BAT2	6	31602048	In_Frame_Del	DEL	GGGCTCTAAGCCTGA	TCGA-DK-A1AC-01A-11D-A13W-08	984331	31602048	139513019	592	12289										
BAT5	7920	broad.mit.edu	37	chr6	31670992	31670992	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacgctggccggggccctttCagagtccctctcccggtaga	13	15	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:31670992C>T	uc003nvy.1	-	1	97	c.67G>A	c.(67-69)GAA>AAA	p.E23K	BAT5_uc003nvx.1_5'Flank|BAT5_uc011dny.1_5'Flank|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_Intron|BAT5_uc010jtc.1_RNA|BAT5_uc011doa.1_5'UTR	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	23						integral to membrane	hydrolase activity|protein binding				0						GGGGCCCTTTCAGAGTCCCTC	0.657													0	0	0	0.00333	0	18	28										T	31670992	C	T	31670992	3	4	46	1	0	0	0	0	1	0	0	0	1324	835	29	1	1850	1	BAT5	6	31670992	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	68944	31670992	139444075	593	12290										
DOM3Z	1797	broad.mit.edu	37	chr6	31938901	31938901	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccccgccacgtcactatgGcctctgccagccagcctgga	10	19	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:31938901G>T	uc003nyo.1	-	2	914	c.380C>A	c.(379-381)GCC>GAC	p.A127D	DOM3Z_uc003nyp.1_Missense_Mutation_p.A127D|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_Missense_Mutation_p.A127D|DOM3Z_uc003nys.1_Missense_Mutation_p.A127D|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	127							identical protein binding|metal ion binding|nucleotide binding				0						CGTCACTATGGCCTCTGCCAG	0.587													1	0	1.75199e-13	0.007291	1.83485e-13	17	21										T	31938901	G	T	31938901	3	4	46	1	0	0	0	0	1	0	0	0	4705	1203	42	4	830	4	DOM3Z	6	31938901	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	267909	31938901	139176166	594	12291										
TNXB	7148	broad.mit.edu	37	chr6	32024681	32024681	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtggtctcggcttcatcctCtggagttggacagacacgtg	14	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:32024681C>T	uc003nzl.2	-	23	8028	c.7826_splice	c.e23-1	p.E2609_splice		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor						actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GCTTCATCCTCTGGAGTTGGA	0.582													0	0	0	0.00499	0	14	41										T	32024681	C	T	32024681	5	4	46	1	0	0	0	0	0	0	1	0	16343	927	32	1	6976	1	TNXB	6	32024681	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	85780	32024681	139090386	595	12292										
PBX2	5089	broad.mit.edu	37	chr6	32157485	32157485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactcacttggcctgggcctCgtccaggctctggtcggtga	13	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:32157485C>T	uc003oav.1	-	1	479	c.208G>A	c.(208-210)GAG>AAG	p.E70K	PBX2_uc003oaw.2_Missense_Mutation_p.E70K	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	70							transcription factor binding			ovary(1)	1						GCCTGGGCCTCGTCCAGGCTC	0.647													0	0	0	0.003163	0	15	34										T	32157485	C	T	32157485	3	4	46	1	0	0	0	0	1	0	0	0	11493	893	31	1	1120	1	PBX2	6	32157485	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	132804	32157485	138957582	596	12293										
HLA-DOA	3111	broad.mit.edu	37	chr6	32977305	32977305	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccaggaccagccctgctctGagggccattacactctggtg	11	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:32977305G>A	uc003ocr.2	-	1	85	c.9C>T	c.(7-9)CTC>CTT	p.L3L	HLA-DOA_uc010juj.2_5'UTR|HLA-DOA_uc010jui.2_Silent_p.L3L	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	3					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GCCCTGCTCTGAGGGCCATTA	0.587													0	0	0	0.009096	0	4	19										A	32977305	G	A	32977305	2	1	46	1	0	0	0	0	0	0	0	1	7200	1277	45	1		1	HLA-DOA	6	32977305	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	819820	32977305	138137762	597	12294										
B3GALT4	8705	broad.mit.edu	37	chr6	33245448	33245448	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcacggctccggagaacctGaaccagagaaacgccattcg	11	13	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:33245448G>C	uc003odr.2	+	1	532	c.252G>C	c.(250-252)CTG>CTC	p.L84L		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	84	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						CGGAGAACCTGAACCAGAGAA	0.667													0	0	0	0.004289	0	36	82										C	33245448	G	C	33245448	2	2	46	1	0	0	0	0	0	0	0	1	1249	1277	45	1		1	B3GALT4	6	33245448	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	268143	33245448	137869619	598	12295										
WDR46	9277	broad.mit.edu	37	chr6	33247078	33247078	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcacaaatctgtccagggcaGatggccgggcccccgtgggc	15	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:33247078G>C	uc003ods.2	-	15	1852	c.1808C>G	c.(1807-1809)TCT>TGT	p.S603C	WDR46_uc011dra.1_Missense_Mutation_p.S549C	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	603											0						GTCCAGGGCAGATGGCCGGGC	0.612													0	0	0	0.010818	0	29	137										C	33247078	G	C	33247078	3	2	46	1	0	0	0	0	1	0	0	0	17296	942	33	1	28	1	WDR46	6	33247078	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1630	33247078	137867989	599	12296										
UHRF1BP1	54887	broad.mit.edu	37	chr6	34831871	34831871	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccatgaagaggacggtatCtcaacagtcatttgatggtg	11	8	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:34831871C>T	uc003oju.3	+	15	3542	c.3308C>T	c.(3307-3309)TCT>TTT	p.S1103F	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_Intron	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1103										ovary(3)	3						AGGACGGTATCTCAACAGTCA	0.522													0	0	0	0.008871	0	16	49										T	34831871	C	T	34831871	3	4	46	1	0	0	0	0	1	0	0	0	16965	913	32	1	3366	1	UHRF1BP1	6	34831871	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1584793	34831871	136283196	600	12297										
C6orf222	389384	broad.mit.edu	37	chr6	36291244	36291244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagctcgaccttttttcttGagatttccttctgcagtgtg	9	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:36291244G>C	uc003oly.2	-	8	1475	c.1297C>G	c.(1297-1299)CAA>GAA	p.Q433E		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	433										skin(2)|ovary(1)|breast(1)	4						CTTTTTTCTTGAGATTTCCTT	0.562													0	0	0	0.01441	0	52	171										C	36291244	G	C	36291244	3	2	46	1	0	0	0	0	1	0	0	0	2356	1299	45	1	681	1	C6orf222	6	36291244	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1459373	36291244	134823823	601	12298										
KCTD20	222658	broad.mit.edu	37	chr6	36452534	36452534	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agattcttcaaatatattgaGaatagggatgttgcaaaaac	8	4	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:36452534G>A	uc003ome.2	+	7	1291	c.900G>A	c.(898-900)GAG>GAA	p.E300E	KCTD20_uc011dtm.1_Silent_p.E155E|KCTD20_uc011dtn.1_Silent_p.E54E|KCTD20_uc010jwk.2_Silent_p.E134E|KCTD20_uc011dto.1_Silent_p.E54E	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	300						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						AATATATTGAGAATAGGGATG	0.343													0	0	0	0.01441	0	125	109										A	36452534	G	A	36452534	2	1	46	1	0	0	0	0	0	0	0	1	8108	933	33	1		1	KCTD20	6	36452534	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	161290	36452534	134662533	602	12299										
CDKN1A	1026	broad.mit.edu	37	chr6	36652272	36652272	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcaggctgaagggtccccaGgtggacctggagactctcag	15	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:36652272G>T	uc003omm.3	+	2	516	c.394G>T	c.(394-396)GGT>TGT	p.G132C	CDKN1A_uc011dtq.1_Missense_Mutation_p.G166C|CDKN1A_uc003oml.2_Missense_Mutation_p.G132C|CDKN1A_uc003omn.2_Missense_Mutation_p.G132C	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	132					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						AGGGTCCCCAGGTGGACCTGG	0.592									Multiple_Endocrine_Neoplasia_type_1				1	0	9.05144e-12	0.001855	9.45218e-12	12	27										T	36652272	G	T	36652272	3	4	46	1	0	0	0	0	1	0	0	0	3158	1000	35	4	396	4	CDKN1A	6	36652272	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	199738	36652272	134462795	603	12300										
FTSJD2	23070	broad.mit.edu	37	chr6	37419600	37419600	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagaaagatgattattgaaGatgaaacagagttttgtggg	13	1	0	7			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:37419600G>C	uc003ons.2	+	6	809	c.556G>C	c.(556-558)GAT>CAT	p.D186H	FTSJD2_uc010jwu.2_Missense_Mutation_p.D186H	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	186					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GATTATTGAAGATGAAACAGA	0.423													0	0	0	0.00278	0	22	62										C	37419600	G	C	37419600	3	2	46	1	0	0	0	0	1	0	0	0	6091	942	33	1	574	1	FTSJD2	6	37419600	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	767328	37419600	133695467	604	12301										
DAAM2	23500	broad.mit.edu	37	chr6	39865036	39865036	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgccttcagagctgcaacatCttccagaagctgccaaagtc	8	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:39865036C>G	uc003oow.2	+	21	2752	c.2596C>G	c.(2596-2598)CTT>GTT	p.L866V	DAAM2_uc003oox.2_Missense_Mutation_p.L866V	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	866	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					GCTGCAACATCTTCCAGAAGC	0.448													0	0	0	0.003755	0	34	80										G	39865036	C	G	39865036	3	3	46	1	0	0	0	0	1	0	0	0	4216	913	32	1	2674	1	DAAM2	6	39865036	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2445436	39865036	131250031	605	12302										
MOCS1	4337	broad.mit.edu	37	chr6	39895072	39895072	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggaaggtgactcacatctGaggttgcacttctctgtgag	12	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:39895072G>A	uc003opb.2	-	1	384	c.246C>T	c.(244-246)CTC>CTT	p.L82L	MOCS1_uc003opa.2_Silent_p.L82L|MOCS1_uc003opc.2_Silent_p.L82L|MOCS1_uc003opd.2_Silent_p.L82L|MOCS1_uc003ope.2_Intron	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	82	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACTCACATCTGAGGTTGCACT	0.602													0	0	0	0.00308	0	8	74										A	39895072	G	A	39895072	2	1	46	1	0	0	0	0	0	0	0	1	9690	1277	45	1		1	MOCS1	6	39895072	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	30036	39895072	131219995	606	12303										
TREML1	340205	broad.mit.edu	37	chr6	41121535	41121535	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagactctgtgcaaaatctGgggccccctggccccatcca	10	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:41121535G>A	uc011duc.1	-	2	381	c.337C>T	c.(337-339)CAG>TAG	p.Q113*	TREML1_uc003opx.2_Nonsense_Mutation_p.Q113*|TREML1_uc011dud.1_Intron	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	113	Ig-like V-type.|Extracellular (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCAAAATCTGGGGCCCCCTG	0.607													0	0	0	0.01441	0	102	37										A	41121535	G	A	41121535	4	1	46	1	0	0	0	0	0	1	0	0	16469	1357	47	2	616	2	TREML1	6	41121535	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1226463	41121535	129993532	607	12304										
TREM2	54209	broad.mit.edu	37	chr6	41129313	41129313	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcagggactggcccgccaCgccctggaacactgtggtgt	14	14	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:41129313C>T	uc003opy.2	-	2	181	c.79G>A	c.(79-81)GTG>ATG	p.V27M	TREM2_uc003opz.2_Missense_Mutation_p.V57M|TREM2_uc010jxl.1_Missense_Mutation_p.V57M	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	27	Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGCCCGCCACGCCCTGGAAC	0.493													0	0	0	0.010729	0	5	51										T	41129313	C	T	41129313	3	4	46	1	0	0	0	0	1	0	0	0	16468	536	19	2	629	2	TREM2	6	41129313	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7778	41129313	129985754	608	12305										
UBR2	23304	broad.mit.edu	37	chr6	42532121	42532121	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttgctggaatgttcggccGaggagattgcgggggtgagt	19	6	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:42532121G>T	uc011dur.1	+	1	64	c.64G>T	c.(64-66)GAG>TAG	p.E22*	UBR2_uc003osf.2_Nonsense_Mutation_p.E22*	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	22					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ATGTTCGGCCGAGGAGATTGC	0.697													1	0	2.17888e-05	0.006214	2.22502e-05	9	7										T	42532121	G	T	42532121	4	4	46	1	0	0	0	0	0	1	0	0	16899	1059	37	3	66	3	UBR2	6	42532121	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1402808	42532121	128582946	609	12306										
TBCC	6903	broad.mit.edu	37	chr6	42713401	42713401	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttccccgggtcttgaaagcGaaacgcttcttgggctgcag	12	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:42713401G>A	uc003osl.2	-	1	484	c.411C>T	c.(409-411)TTC>TTT	p.F137F		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	137					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			TCTTGAAAGCGAAACGCTTCT	0.662													0	0	0	0.001984	0	6	41										A	42713401	G	A	42713401	2	1	46	1	0	0	0	0	0	0	0	1	15628	1049	37	1		1	TBCC	6	42713401	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	181280	42713401	128401666	610	12307										
MEA1	4201	broad.mit.edu	37	chr6	42981053	42981053	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccctgatgtcccagttcctCagtctgattggggaagatac	11	11	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:42981053C>T	uc003otk.2	-	2	170	c.103G>A	c.(103-105)GAG>AAG	p.E35K	MEA1_uc010jyc.1_Missense_Mutation_p.E22K|KLHDC3_uc003otl.2_5'Flank|KLHDC3_uc003otm.2_5'Flank|KLHDC3_uc010jyf.2_5'Flank|KLHDC3_uc003otn.2_5'Flank	NM_014623	NP_055438	Q16626	MEA1_HUMAN	male-enhanced antigen	35					cell differentiation|male gonad development|spermatogenesis		protein binding			central_nervous_system(1)|skin(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCAGTTCCTCAGTCTGATTG	0.522													0	0	0	0.008361	0	28	157										T	42981053	C	T	42981053	3	4	46	1	0	0	0	0	1	0	0	0	9420	835	29	1	466	1	MEA1	6	42981053	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	267652	42981053	128134014	611	12308										
CUL9	23113	broad.mit.edu	37	chr6	43181188	43181188	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcatcaggaggtgtcagtaGagaccttgctgaaggattct	12	8	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43181188G>C	uc003ouk.2	+	28	5446	c.5371G>C	c.(5371-5373)GAG>CAG	p.E1791Q	CUL9_uc003oul.2_Missense_Mutation_p.E1791Q|CUL9_uc010jyk.2_Missense_Mutation_p.E943Q|CUL9_uc003oun.2_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1791					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGTGTCAGTAGAGACCTTGCT	0.557													0	0	0	0.001855	0	13	96										C	43181188	G	C	43181188	3	2	46	1	0	0	0	0	1	0	0	0	4061	943	33	1	5477	1	CUL9	6	43181188	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	200135	43181188	127933879	612	12309										
CUL9	23113	broad.mit.edu	37	chr6	43190340	43190340	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgcccagatccttcaccttCctcaatgatgcctgccaggg	8	17	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43190340C>T	uc003ouk.2	+	37	7068	c.6993C>T	c.(6991-6993)TTC>TTT	p.F2331F	CUL9_uc003oul.2_Silent_p.F2303F|CUL9_uc010jyk.2_Silent_p.F1483F|CUL9_uc003oun.2_Silent_p.F126F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2331					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCTTCACCTTCCTCAATGATG	0.607													0	0	0	0.00632	0	27	39										T	43190340	C	T	43190340	2	4	46	1	0	0	0	0	0	0	0	1	4061	854	30	1		1	CUL9	6	43190340	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9152	43190340	127924727	613	12310										
ZNF318	24149	broad.mit.edu	37	chr6	43323779	43323779	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atagtccccttgttttcaatCtctgaggcaaaagcagcaat	7	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43323779C>T	uc003oux.2	-	4	1371	c.1293G>A	c.(1291-1293)GAG>GAA	p.E431E	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	431					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TGTTTTCAATCTCTGAGGCAA	0.522													0	0	0	0.01441	0	72	84										T	43323779	C	T	43323779	2	4	46	1	0	0	0	0	0	0	0	1	17833	912	32	1		1	ZNF318	6	43323779	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	133439	43323779	127791288	614	12311										
C6orf154	221424	broad.mit.edu	37	chr6	43475602	43475602	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagccctgtgccctccaagtCtaggacctctagggtacgac	11	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43475602C>T	uc003ovk.1	-	4	1520	c.619G>A	c.(619-621)GAC>AAC	p.D207N	C6orf154_uc003ovj.1_Missense_Mutation_p.D16N	NM_001012974	NP_001012992	Q5JTD7	CF154_HUMAN	hypothetical protein LOC221424	207	LRR 6.										0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			CCCTCCAAGTCTAGGACCTCT	0.562													0	0	0	0.001984	0	7	36										T	43475602	C	T	43475602	3	4	46	1	0	0	0	0	1	0	0	0	2339	913	32	1	343	1	C6orf154	6	43475602	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	151823	43475602	127639465	615	12312										
GPR110	266977	broad.mit.edu	37	chr6	46977464	46977464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaggtgacatcaatatggaGaaggaggtcaagtgagtaca	13	4	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:46977464G>A	uc003oyt.2	-	11	1906	c.1707C>T	c.(1705-1707)TTC>TTT	p.F569F	GPR110_uc011dwl.1_Silent_p.F257F	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	569	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TCAATATGGAGAAGGAGGTCA	0.358													0	0	0	0.00499	0	16	67										A	46977464	G	A	46977464	2	1	46	1	0	0	0	0	0	0	0	1	6627	933	33	1		1	GPR110	6	46977464	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3501862	46977464	124137603	616	12313										
CRISP3	10321	broad.mit.edu	37	chr6	49700942	49700942	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaaacatagtagtattttaGaactttttgattgggacagt	9	4	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:49700942G>C	uc003ozs.2	-	6	502	c.487C>G	c.(487-489)CTA>GTA	p.L163V		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	163					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TAGTATTTTAGAACTTTTTGA	0.303													0	0	0	0.00623	0	40	161										C	49700942	G	C	49700942	3	2	46	1	0	0	0	0	1	0	0	0	3881	933	33	1	262	1	CRISP3	6	49700942	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2723478	49700942	121414125	617	12314										
PGK2	5232	broad.mit.edu	37	chr6	49753659	49753659	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatattaactacatgttgctGagggcctctactccaggaag	9	9	1	1	rs142237772	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:49753659G>A	uc003ozu.2	-	1	1349	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	414					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					ACATGTTGCTGAGGGCCTCTA	0.433													0	0	0	0.006999	0	38	60										A	49753659	G	A	49753659	2	1	46	1	0	0	0	0	0	0	0	1	11791	1277	45	1		1	PGK2	6	49753659	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	52717	49753659	121361408	618	12315										
PKHD1	5314	broad.mit.edu	37	chr6	51612670	51612670	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactgatttggttctgaggtGaatacaggccacagaatacc	10	9	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:51612670G>A	uc003pah.1	-	58	10020	c.9744C>T	c.(9742-9744)TTC>TTT	p.F3248F	PKHD1_uc010jzn.1_Silent_p.F1231F|PKHD1_uc003pai.2_Silent_p.F3248F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3248	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTTCTGAGGTGAATACAGGCC	0.448													0	0	0	0.01441	0	53	97										A	51612670	G	A	51612670	2	1	46	1	0	0	0	0	0	0	0	1	11971	1281	45	1		1	PKHD1	6	51612670	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1859011	51612670	119502397	619	12316										
IL17F	112744	broad.mit.edu	37	chr6	52103570	52103570	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcggctctcgatgttacgtGacatggaaacgcgctggttt	13	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:52103570G>C	uc003pam.1	-	2	283	c.212C>G	c.(211-213)TCA>TGA	p.S71*	IL17F_uc003pal.1_Nonsense_Mutation_p.S17*	NM_052872	NP_443104	Q96PD4	IL17F_HUMAN	interleukin 17F precursor	71					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			ovary(1)	1	Lung NSC(77;0.116)					GATGTTACGTGACATGGAAAC	0.438													0	0	0	0.010729	0	11	48										C	52103570	G	C	52103570	4	2	46	1	0	0	0	0	0	1	0	0	7638	1294	45	1	287	1	IL17F	6	52103570	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	490900	52103570	119011497	620	12317										
MCM3	4172	broad.mit.edu	37	chr6	52129560	52129560	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttcccggaacacatccaaGagggccaccttgaatgcctt	9	14	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:52129560G>C	uc003pan.1	-	17	2363	c.2253C>G	c.(2251-2253)CTC>CTG	p.L751L	MCM3_uc011dwu.1_Silent_p.L705L	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	751					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					ACACATCCAAGAGGGCCACCT	0.507													0	0	0	0.01441	0	56	91										C	52129560	G	C	52129560	2	2	46	1	0	0	0	0	0	0	0	1	9387	929	33	1		1	MCM3	6	52129560	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	25990	52129560	118985507	621	12318										
GSTA5	221357	broad.mit.edu	37	chr6	52701150	52701150	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcaaccattggtacttgctgGaacagcaaactcccatctta	6	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:52701150G>A	uc003pba.1	-	4	226	c.156C>T	c.(154-156)TTC>TTT	p.F52F		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	52	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	GTACTTGCTGGAACAGCAAAC	0.403													0	0	0	0.008361	0	30	149										A	52701150	G	A	52701150	2	1	46	1	0	0	0	0	0	0	0	1	6834	1165	41	1		1	GSTA5	6	52701150	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	571590	52701150	118413917	622	12319										
LRRC1	55227	broad.mit.edu	37	chr6	53660187	53660187	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaggagctgctgctggacGccaaccagctccgcgagctg	15	13	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:53660187G>C	uc003pcd.1	+	1	410	c.133G>C	c.(133-135)GCC>CCC	p.A45P		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	45	LRR 2.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GCTGCTGGACGCCAACCAGCT	0.667													0	0	0	0.004007	0	12	13										C	53660187	G	C	53660187	3	2	46	1	0	0	0	0	1	0	0	0	8966	1087	38	4	135	4	LRRC1	6	53660187	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	959037	53660187	117454880	623	12320										
BMP5	653	broad.mit.edu	37	chr6	55739327	55739327	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaggctgggtatccctttcTtgcccctctggtctcttctg	10	13	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:55739327T>C	uc003pcq.2	-	1	1049	c.337A>G	c.(337-339)AGA>GGA	p.R113G	BMP5_uc011dxf.1_Missense_Mutation_p.R113G	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	113					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TATCCCTTTCTTGCCCCTCTG	0.522													0	0	0	0.012319	0	21	92										C	55739327	T	C	55739327	3	2	46	1	0	0	0	0	1	0	0	0	1463	1617	56	5	1055	5	BMP5	6	55739327	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2079140	55739327	115375740	624	12321										
RAB23	51715	broad.mit.edu	37	chr6	57075078	57075078	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttcttgtagtcttttgtaAaaatgcctttgcaatatcgc	6	7	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:57075078A>C	uc003pds.2	-	2	307	c.101T>G	c.(100-102)TTT>TGT	p.F34C	RAB23_uc003pdt.2_Missense_Mutation_p.F34C|RAB23_uc010kac.2_Missense_Mutation_p.F34C|RAB23_uc010kad.2_RNA	NM_183227	NP_899050	Q9ULC3	RAB23_HUMAN	Ras-related protein Rab-23	34					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GTCTTTTGTAAAAATGCCTTT	0.373													0	0	0	0.006999	0	42	137										C	57075078	A	C	57075078	3	2	46	1	0	0	0	0	1	0	0	0	12910	14	1	5	636	5	RAB23	6	57075078	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1335751	57075078	114039989	625	12322										
PRIM2	5558	broad.mit.edu	37	chr6	57183276	57183276	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaagaaagtggaggaagctGaggttggcaggtgaccagag	19	4	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:57183276G>A	uc003pdx.2	+	2	120	c.33G>A	c.(31-33)CTG>CTA	p.L11L	PRIM2_uc003pdv.1_Silent_p.L11L|PRIM2_uc003pdw.2_Silent_p.L11L	NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	11					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GGAGGAAGCTGAGGTTGGCAG	0.403													0	0	0	0.006214	0	9	16										A	57183276	G	A	57183276	2	1	46	1	0	0	0	0	0	0	0	1	12491	1277	45	1		1	PRIM2	6	57183276	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	108198	57183276	113931791	626	12323										
COL19A1	1310	broad.mit.edu	37	chr6	70875842	70875842	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcccttgcagggcagcgacGgaccccctgggaaacccgga	13	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:70875842G>A	uc003pfc.1	+	37	2527	c.2410G>A	c.(2410-2412)GGA>AGA	p.G804R	COL19A1_uc010kam.1_Missense_Mutation_p.G700R	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	804	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGGCAGCGACGGACCCCCTGG	0.443													0	0	0	0.007291	0	28	171										A	70875842	G	A	70875842	3	1	46	1	0	0	0	0	1	0	0	0	3676	1117	39	2	2552	2	COL19A1	6	70875842	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	13692566	70875842	100239225	627	12324										
COL9A1	1297	broad.mit.edu	37	chr6	70966509	70966509	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgaggcccaggttcaccatCtaagccccgagcaccctgca	9	17	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:70966509C>T	uc003pfg.3	-	21	1624	c.1465G>A	c.(1465-1467)GAT>AAT	p.D489N	COL9A1_uc003pfe.3_Missense_Mutation_p.D62N|COL9A1_uc003pff.3_Missense_Mutation_p.D246N	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	489	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGTTCACCATCTAAGCCCCGA	0.383													0	0	0	0.009096	0	3	33										T	70966509	C	T	70966509	3	4	46	1	0	0	0	0	1	0	0	0	3707	913	32	1	1372	1	COL9A1	6	70966509	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	90667	70966509	100148558	628	12325										
RIMS1	22999	broad.mit.edu	37	chr6	72892790	72892790	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgaggaggagggcgtgtCgacgcccgagtacaccagct	15	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:72892790C>T	uc003pga.2	+	6	1693	c.1616C>T	c.(1615-1617)TCG>TTG	p.S539L	RIMS1_uc011dyb.1_Missense_Mutation_p.S165L|RIMS1_uc003pgc.2_Missense_Mutation_p.S165L|RIMS1_uc003pgb.3_Missense_Mutation_p.S165L	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	539					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GAGGGCGTGTCGACGCCCGAG	0.692													0	0	0	0.004672	0	3	3										T	72892790	C	T	72892790	3	4	46	1	0	0	0	0	1	0	0	0	13367	893	31	1	1638	1	RIMS1	6	72892790	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1926281	72892790	98222277	629	12326										
RIMS1	22999	broad.mit.edu	37	chr6	72968754	72968754	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagacaccatgatgcctcccGaagtccagttgatcatagaa	8	12	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:72968754G>A	uc003pga.2	+	18	3070	c.2993G>A	c.(2992-2994)CGA>CAA	p.R998Q	RIMS1_uc011dyb.1_Missense_Mutation_p.R623Q|RIMS1_uc003pgc.2_Missense_Mutation_p.R624Q|RIMS1_uc010kaq.2_Missense_Mutation_p.R471Q|RIMS1_uc011dyc.1_Missense_Mutation_p.R472Q|RIMS1_uc010kar.2_Missense_Mutation_p.R391Q|RIMS1_uc011dyd.1_Missense_Mutation_p.R457Q|RIMS1_uc003pgf.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgg.2_Missense_Mutation_p.R215Q|RIMS1_uc003pgi.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgh.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgd.2_Missense_Mutation_p.R215Q|RIMS1_uc003pge.2_Missense_Mutation_p.R215Q|RIMS1_uc011dye.1_5'UTR|RIMS1_uc011dyf.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.R624Q|RIMS1_uc010kas.1_Missense_Mutation_p.R457Q	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	998					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GATGCCTCCCGAAGTCCAGTT	0.353													0	0	0	0.01441	0	53	73										A	72968754	G	A	72968754	3	1	46	1	0	0	0	0	1	0	0	0	13367	1058	37	1	3226	1	RIMS1	6	72968754	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	75964	72968754	98146313	630	12327										
KCNQ5	56479	broad.mit.edu	37	chr6	73843259	73843259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagcaccgacatcacagccGagggcagtcccaccaaagtg	10	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:73843259G>A	uc003pgk.2	+	10	1710	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K	KCNQ5_uc011dyh.1_Missense_Mutation_p.E474K|KCNQ5_uc011dyi.1_Missense_Mutation_p.E465K|KCNQ5_uc010kat.2_Missense_Mutation_p.E446K|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Missense_Mutation_p.E205K	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	455					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CATCACAGCCGAGGGCAGTCC	0.592													0	0	0	0.014323	0	22	68										A	73843259	G	A	73843259	3	1	46	1	0	0	0	0	1	0	0	0	8086	1059	37	1	1462	1	KCNQ5	6	73843259	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	874505	73843259	97271808	631	12328										
KCNQ5	56479	broad.mit.edu	37	chr6	73904551	73904551	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cattgcaaaccaaataaataCggcacccaagccagcagccc	6	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:73904551C>T	uc003pgk.2	+	14	2560	c.2213C>T	c.(2212-2214)ACG>ATG	p.T738M	KCNQ5_uc011dyh.1_Missense_Mutation_p.T757M|KCNQ5_uc011dyi.1_Missense_Mutation_p.T748M|KCNQ5_uc010kat.2_Missense_Mutation_p.T729M|KCNQ5_uc011dyj.1_Missense_Mutation_p.T628M|KCNQ5_uc011dyk.1_Missense_Mutation_p.T488M	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	738					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CAAATAAATACGGCACCCAAG	0.532													0	0	0	0.014323	0	20	22										T	73904551	C	T	73904551	3	4	46	1	0	0	0	0	1	0	0	0	8086	536	19	2	2328	2	KCNQ5	6	73904551	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	61292	73904551	97210516	632	12329										
C6orf150	115004	broad.mit.edu	37	chr6	74150017	74150017	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctaacttttgctgaaagCcagttttgaatgcgcaggcc	9	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:74150017C>T	uc003pgx.1	-	3	1168	c.1029G>A	c.(1027-1029)TGG>TGA	p.W343*		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	343											0						TTGCTGAAAGCCAGTTTTGAA	0.393													0	0	0	0.01441	0	49	93										T	74150017	C	T	74150017	4	4	46	1	0	0	0	0	0	1	0	0	2337	740	26	2	551	2	C6orf150	6	74150017	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	245466	74150017	96965050	633	12330										
CD109	135228	broad.mit.edu	37	chr6	74440088	74440088	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacctctgaacagtgcagatGagatttatgagctacgtgta	10	7	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:74440088G>A	uc003php.2	+	4	723	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CD109_uc010kaz.2_Missense_Mutation_p.E100K|CD109_uc003phq.2_Missense_Mutation_p.E100K|CD109_uc010kba.2_Intron	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	100						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						CAGTGCAGATGAGATTTATGA	0.373													0	0	0	0.008361	0	30	135										A	74440088	G	A	74440088	3	1	46	1	0	0	0	0	1	0	0	0	2963	1291	45	1	312	1	CD109	6	74440088	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	290071	74440088	96674979	634	12331										
SENP6	26054	broad.mit.edu	37	chr6	76425252	76425252	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagcataaggacacttactCaacagaagcacctttaggcg	8	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:76425252C>G	uc003pid.3	+	24	3900	c.3281C>G	c.(3280-3282)TCA>TGA	p.S1094*	SENP6_uc003pie.3_Nonsense_Mutation_p.S1087*|SENP6_uc010kbf.2_RNA	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	1094	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GACACTTACTCAACAGAAGCA	0.363													0	0	0	0.01441	0	57	80										G	76425252	C	G	76425252	4	3	46	1	0	0	0	0	0	1	0	0	14050	838	29	1	3375	1	SENP6	6	76425252	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1985164	76425252	94689815	635	12332										
IMPG1	3617	broad.mit.edu	37	chr6	76657219	76657219	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtatttcaagttgcttaaatCctgtaagattggatcgtaga	9	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:76657219C>T	uc003pik.1	-	14	1986	c.1856G>A	c.(1855-1857)GGA>GAA	p.G619E		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	619	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTGCTTAAATCCTGTAAGATT	0.393													0	0	0	0.008291	0	10	22										T	76657219	C	T	76657219	3	4	46	1	0	0	0	0	1	0	0	0	7728	855	30	1	553	1	IMPG1	6	76657219	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	231967	76657219	94457848	636	12333										
LCA5	167691	broad.mit.edu	37	chr6	80228490	80228490	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctaacacttgcaggtgaaGaactgaccagcgatgatcgg	11	10	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:80228490G>A	uc003pix.2	-	2	557	c.122C>T	c.(121-123)TCT>TTT	p.S41F	LCA5_uc003piy.2_Missense_Mutation_p.S41F|LCA5_uc011dyq.1_RNA|LCA5_uc011dyr.1_Missense_Mutation_p.S41F	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	41					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TGCAGGTGAAGAACTGACCAG	0.423													0	0	0	0.01441	0	108	200										A	80228490	G	A	80228490	3	1	46	1	0	0	0	0	1	0	0	0	8656	942	33	1	1999	1	LCA5	6	80228490	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3571271	80228490	90886577	637	12334										
CYB5R4	51167	broad.mit.edu	37	chr6	84618805	84618805	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccattaaacctgctgttctGaaaggtaagtggtgctggtg	13	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:84618805G>A	uc003pkf.2	+	4	540	c.408G>A	c.(406-408)CTG>CTA	p.L136L		NM_016230	NP_057314	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	136					cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(2)	2		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		CTGCTGTTCTGAAAGGTAAGT	0.393													0	0	0	0.006214	0	10	54										A	84618805	G	A	84618805	2	1	46	1	0	0	0	0	0	0	0	1	4129	1277	45	1		1	CYB5R4	6	84618805	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4390315	84618805	86496262	638	12335										
KIAA1009	22832	broad.mit.edu	37	chr6	84862559	84862559	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcattcttctgtctttctGaagcctctccacagtttttg	5	12	6	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:84862559G>A	uc010kbp.2	-	23	3431	c.3334C>T	c.(3334-3336)CAG>TAG	p.Q1112*	KIAA1009_uc003pkj.3_Nonsense_Mutation_p.Q1036*|KIAA1009_uc003pki.3_Nonsense_Mutation_p.Q498*	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	1112	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CTGTCTTTCTGAAGCCTCTCC	0.403													0	0	0	0.005443	0	28	52										A	84862559	G	A	84862559	4	1	46	1	0	0	0	0	0	1	0	0	8203	1299	45	1	897	1	KIAA1009	6	84862559	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	243754	84862559	86252508	639	12336										
GABRR1	2569	broad.mit.edu	37	chr6	89888585	89888585	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggcgtgggtgtcgattctCatgctcacatagctgcttct	11	10	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:89888585C>G	uc003pna.2	-	10	1799	c.1344G>C	c.(1342-1344)ATG>ATC	p.M448I	GABRR1_uc011dzv.1_Missense_Mutation_p.M425I	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	448	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TGTCGATTCTCATGCTCACAT	0.463													0	0	0	0.01441	0	44	173										G	89888585	C	G	89888585	3	3	46	1	0	0	0	0	1	0	0	0	6176	826	29	1	99	1	GABRR1	6	89888585	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5026026	89888585	81226482	640	12337										
MAP3K7	6885	broad.mit.edu	37	chr6	91257893	91257893	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagaagcaatgtccatgaatGagcctaggaaaagcagaaac	10	7	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:91257893G>A	uc003pnz.1	-	10	1115	c.953C>T	c.(952-954)TCA>TTA	p.S318L	MAP3K7_uc003poa.1_Missense_Mutation_p.S318L|MAP3K7_uc003pob.1_Missense_Mutation_p.S318L|MAP3K7_uc003poc.1_Missense_Mutation_p.S318L	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	318					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GTCCATGAATGAGCCTAGGAA	0.343													0	0	0	0.006999	0	40	64										A	91257893	G	A	91257893	3	1	46	1	0	0	0	0	1	0	0	0	9255	1294	45	1	899	1	MAP3K7	6	91257893	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1369308	91257893	79857174	641	12338										
KLHL32	114792	broad.mit.edu	37	chr6	97587083	97587083	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatggaatagcagcatgcttCcttccagctccatattttac	6	11	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:97587083C>T	uc010kcm.1	+	11	2260	c.1788C>T	c.(1786-1788)TTC>TTT	p.F596F	KLHL32_uc011ead.1_Silent_p.F560F|KLHL32_uc003poz.2_Silent_p.F152F|KLHL32_uc011eae.1_Silent_p.F527F|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	596	Kelch 6.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CAGCATGCTTCCTTCCAGCTC	0.448													0	0	0	0.004878	0	38	153										T	97587083	C	T	97587083	2	4	46	1	0	0	0	0	0	0	0	1	8386	854	30	1		1	KLHL32	6	97587083	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6329190	97587083	73527984	642	12339										
C6orf167	253714	broad.mit.edu	37	chr6	97626329	97626329	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgacaaatacctcaaagaatCgaacaagtgcttttttaggg	8	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:97626329C>G	uc003ppb.2	-	18	2935	c.2669G>C	c.(2668-2670)CGA>CCA	p.R890P	C6orf167_uc011eaf.1_Missense_Mutation_p.R850P	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	890					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CTCAAAGAATCGAACAAGTGC	0.274													0	0	0	0.00499	0	16	117										G	97626329	C	G	97626329	3	3	46	1	0	0	0	0	1	0	0	0	2342	884	31	1	1094	1	C6orf167	6	97626329	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	39246	97626329	73488738	643	12340										
CCNC	892	broad.mit.edu	37	chr6	99994315	99994315	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcaaaccattgcctggcatCtttctgctgtacaacacagg	8	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:99994315C>G	uc003pqe.2	-	10	921	c.634G>C	c.(634-636)GAT>CAT	p.D212H	uc003pqc.2_Intron|CCNC_uc003pqd.2_Missense_Mutation_p.D127H|CCNC_uc010kcr.2_RNA|CCNC_uc010kcs.2_Missense_Mutation_p.D211H|CCNC_uc011eah.1_Missense_Mutation_p.D127H	NM_005190	NP_005181	P24863	CCNC_HUMAN	cyclin C isoform a	212					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme	protein kinase binding				0		all_cancers(76;8.46e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.064)		TGCCTGGCATCTTTCTGCTGT	0.358													0	0	0	0.008871	0	17	102										G	99994315	C	G	99994315	3	3	46	1	0	0	0	0	1	0	0	0	2915	913	32	1	229	1	CCNC	6	99994315	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2367986	99994315	71120752	644	12341										
ATG5	9474	broad.mit.edu	37	chr6	106649864	106649864	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taccttcaggatcaatagcaGaaggacaaacttctttgagg	9	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:106649864G>A	uc003prf.2	-	7	1027	c.674C>T	c.(673-675)TCT>TTT	p.S225F	ATG5_uc010kdb.2_3'UTR|ATG5_uc003prg.2_Missense_Mutation_p.S147F|ATG5_uc010kdc.2_3'UTR	NM_004849	NP_004840	Q9H1Y0	ATG5_HUMAN	APG5 autophagy 5-like	225					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			large_intestine(1)	1	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		ATCAATAGCAGAAGGACAAAC	0.378													0	0	0	0.01441	0	53	58										A	106649864	G	A	106649864	3	1	46	1	0	0	0	0	1	0	0	0	1100	942	33	1	161	1	ATG5	6	106649864	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6655549	106649864	64465203	645	12342										
SESN1	27244	broad.mit.edu	37	chr6	109415101	109415101	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtagcttattcaacccatccGaagactcggtatttgaaagc	8	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:109415101G>A	uc003psu.2	-	1	187	c.176C>T	c.(175-177)TCG>TTG	p.S59L	C6orf182_uc003psv.3_5'Flank|C6orf182_uc003psw.3_5'Flank|C6orf182_uc010kdk.2_5'Flank|C6orf182_uc003psx.3_5'Flank|C6orf182_uc010kdl.2_5'Flank	NM_014454	NP_055269	Q9Y6P5	SESN1_HUMAN	sestrin 1	Error:Variant_position_missing_in_Q9Y6P5_after_alignment					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				ovary(1)	1		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		CAACCCATCCGAAGACTCGGT	0.423													0	0	0	0.01441	0	74	110										A	109415101	G	A	109415101	3	1	46	1	0	0	0	0	1	0	0	0	14124	1059	37	1	1519	1	SESN1	6	109415101	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2765237	109415101	61699966	646	12343										
CD164	8763	broad.mit.edu	37	chr6	109700850	109700850	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacaggaaacgcagctgtttCgaccttcacaggtttctggg	11	10	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:109700850C>T	uc003pte.2	-	2	372	c.191G>A	c.(190-192)CGA>CAA	p.R64Q	CD164_uc003ptd.2_Missense_Mutation_p.R64Q|CD164_uc003ptf.2_Missense_Mutation_p.R64Q|CD164_uc011eap.1_Missense_Mutation_p.R64Q|CD164_uc010kdn.2_Missense_Mutation_p.R64Q	NM_006016	NP_006007	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin isoform 1	64	Extracellular (Potential).				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding				0		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		GCAGCTGTTTCGACCTTCACA	0.358													0	0	0	0.01441	0	67	65										T	109700850	C	T	109700850	3	4	46	1	0	0	0	0	1	0	0	0	2969	884	31	1	473	1	CD164	6	109700850	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	285749	109700850	61414217	647	12344										
FAM26D	221301	broad.mit.edu	37	chr6	116879249	116879249	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcttgtcaggactggaaaGatatttcagtacccactctt	7	10	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:116879249G>A	uc003pxa.2	+	4	690	c.391G>A	c.(391-393)GAT>AAT	p.D131N	FAM26D_uc003pwz.2_Missense_Mutation_p.D88N|FAM26D_uc010ked.2_Missense_Mutation_p.D130N	NM_153036	NP_694581	Q5JW98	FA26D_HUMAN	hypothetical protein LOC221301	274						integral to membrane					0		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		GGACTGGAAAGATATTTCAGT	0.453													0	0	0	0.01441	0	54	101										A	116879249	G	A	116879249	3	1	46	1	0	0	0	0	1	0	0	0	5549	942	33	1	264	1	FAM26D	6	116879249	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7178399	116879249	54235818	648	12345										
FAM162B	221303	broad.mit.edu	37	chr6	117086385	117086385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttcttgtcgaactgcgaaGgcctgcgctgcgtggggact	14	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:117086385G>A	uc003pxi.2	-	2	353	c.206C>T	c.(205-207)CCT>CTT	p.P69L		NM_001085480	NP_001078949	Q5T6X4	F162B_HUMAN	hypothetical protein LOC221303	69						integral to membrane					0						GAACTGCGAAGGCCTGCGCTG	0.627													0	0	0	0.00499	0	16	25										A	117086385	G	A	117086385	3	1	46	1	0	0	0	0	1	0	0	0	5475	1000	35	2	294	2	FAM162B	6	117086385	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	207136	117086385	54028682	649	12346										
GPRC6A	222545	broad.mit.edu	37	chr6	117127788	117127788	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acatatgcgcaggcagataaAtgcatggcatattcatgtaa	9	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:117127788A>C	uc003pxj.1	-	3	1102	c.1080T>G	c.(1078-1080)CAT>CAG	p.H360Q	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.H360Q	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	360	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AGGCAGATAAATGCATGGCAT	0.398													0	0	0	0.003954	0	26	101										C	117127788	A	C	117127788	3	2	46	1	0	0	0	0	1	0	0	0	6728	98	4	5	1716	5	GPRC6A	6	117127788	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	41403	117127788	53987279	650	12347										
MAN1A1	4121	broad.mit.edu	37	chr6	119669855	119669855	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagagcccgctcgtggttttCgcggatcctggccaagttgt	14	11	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:119669855C>T	uc003pym.1	-	2	818	c.376G>A	c.(376-378)GAA>AAA	p.E126K	MAN1A1_uc010kei.1_Missense_Mutation_p.E126K	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	126	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TCGTGGTTTTCGCGGATCCTG	0.507													0	0	0	0.00333	0	24	41										T	119669855	C	T	119669855	3	4	46	1	0	0	0	0	1	0	0	0	9210	893	31	1	1633	1	MAN1A1	6	119669855	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2542067	119669855	51445212	651	12348										
NCOA7	135112	broad.mit.edu	37	chr6	126203598	126203598	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacttagcacgaaaggccttGaaacccattgaaagagtctt	9	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:126203598G>A	uc010kes.2	+	9	1049	c.600G>A	c.(598-600)TTG>TTA	p.L200L	NCOA7_uc003qae.3_Silent_p.L200L|NCOA7_uc003qah.2_Silent_p.L200L|NCOA7_uc003qai.2_Silent_p.L200L|NCOA7_uc010ket.2_Silent_p.L96L|NCOA7_uc003qaf.2_Silent_p.L200L|NCOA7_uc003qag.2_Silent_p.L200L	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	200					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAAAGGCCTTGAAACCCATTG	0.358													0	0	0	0.006122	0	18	38										A	126203598	G	A	126203598	2	1	46	1	0	0	0	0	0	0	0	1	10234	1281	45	1		1	NCOA7	6	126203598	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6533743	126203598	44911469	652	12349										
LAMA2	3908	broad.mit.edu	37	chr6	129674397	129674412	+	Frame_Shift_Del	DEL	CCCTGTGACCCTGTCA	CCCTGTGACCCTGTCA	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctatggctcactgcctgtgCcctgtgaccctgtcacagga							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:129674397_129674412delCCCTGTGACCCTGTCA	uc003qbn.2	+	32	4717_4732	c.4612_4627delCCCTGTGACCCTGTCA	c.(4612-4629)CCCTGTGACCCTGTCACAfs	p.P1538fs	LAMA2_uc003qbo.2_Frame_Shift_Del_p.P1538fs	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1538_1543	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ACTGCCTGTGCCCTGTGACCCTGTCACAGGATTCTG	0.583																		23	62	---	---								-	129674412	CCCTGTGACCCTGTCA	-	129674397	7	5	46	1	0	1	0	1	0	0	0	0	8606	739	26	0	4738	0	LAMA2	6	129674397	Frame_Shift_Del	DEL	CCCTGTGACCCTGTCA	TCGA-DK-A1AC-01A-11D-A13W-08	3470799	129674397	41440670	653	12350										
LAMA2	3908	broad.mit.edu	37	chr6	129796544	129796544	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgttatctagtatgaaagcAaggtaaaatttaaatttatg	7	4	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:129796544A>C	uc003qbn.2	+	52	7554	c.7449A>C	c.(7447-7449)GCA>GCC	p.A2483A	LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2483	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTATGAAAGCAAGGTAAAATT	0.318													0	0	0	0.008291	0	10	33										C	129796544	A	C	129796544	2	2	46	1	0	0	0	0	0	0	0	1	8606	117	5	5		5	LAMA2	6	129796544	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	122147	129796544	41318523	654	12351										
L3MBTL3	84456	broad.mit.edu	37	chr6	130376350	130376350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtaagaatcctgaggggttCgcagagagcacggaggaaaa	15	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:130376350C>T	uc003qbt.2	+	8	787	c.617C>T	c.(616-618)TCG>TTG	p.S206L	L3MBTL3_uc003qbu.2_Missense_Mutation_p.S181L	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	206					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CTGAGGGGTTCGCAGAGAGCA	0.383													0	0	0	0.006214	0	7	64										T	130376350	C	T	130376350	3	4	46	1	0	0	0	0	1	0	0	0	8593	893	31	1	639	1	L3MBTL3	6	130376350	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	579806	130376350	40738717	655	12352										
BCLAF1	9774	broad.mit.edu	37	chr6	136596991	136596991	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggaattacctgttagaatCatcaagaggaacaggtgcca	10	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:136596991C>T	uc003qgx.1	-	5	1925	c.1672G>A	c.(1672-1674)GAT>AAT	p.D558N	BCLAF1_uc003qgw.1_Missense_Mutation_p.D385N|BCLAF1_uc003qgy.1_Missense_Mutation_p.D556N|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.D556N	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	558					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTGTTAGAATCATCAAGAGGA	0.383													0	0	0	0.01441	0	71	169										T	136596991	C	T	136596991	3	4	46	1	0	0	0	0	1	0	0	0	1383	826	29	1	1126	1	BCLAF1	6	136596991	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6220641	136596991	34518076	656	12353										
MAP3K5	4217	broad.mit.edu	37	chr6	137017141	137017141	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggtgatgggaggccaaatCaaaggttggcagtttttcta	13	5	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:137017141C>G	uc003qhc.2	-	6	1391	c.1030G>C	c.(1030-1032)GAT>CAT	p.D344H	MAP3K5_uc011edk.1_Missense_Mutation_p.D189H|MAP3K5_uc010kgw.1_Missense_Mutation_p.D344H	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	344					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GAGGCCAAATCAAAGGTTGGC	0.358													0	0	0	0.007835	0	37	65										G	137017141	C	G	137017141	3	3	46	1	0	0	0	0	1	0	0	0	9253	826	29	1	3194	1	MAP3K5	6	137017141	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	420150	137017141	34097926	657	12354										
CCDC28A	25901	broad.mit.edu	37	chr6	139094917	139094917	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcacttccgtaaacaaacgGagctgcggaggagcgggtcc	14	11	1	0	rs34991012	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:139094917G>A	uc003qie.2	+	1	261	c.106G>A	c.(106-108)GAG>AAG	p.E36K	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	36											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TAAACAAACGGAGCTGCGGAG	0.657													0	0	0	0.003271	0	29	138										A	139094917	G	A	139094917	3	1	46	1	0	0	0	0	1	0	0	0	2802	1175	41	1	108	1	CCDC28A	6	139094917	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2077776	139094917	32020150	658	12355										
CCDC28A	25901	broad.mit.edu	37	chr6	139094928	139094928	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaacaaacggagctgcggagGagcgggtcccgggatgtgac	17	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:139094928G>A	uc003qie.2	+	1	272	c.117G>A	c.(115-117)AGG>AGA	p.R39R	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	39											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		AGCTGCGGAGGAGCGGGTCCC	0.647													0	0	0	0.009535	0	23	131										A	139094928	G	A	139094928	2	1	46	1	0	0	0	0	0	0	0	1	2802	1165	41	1		1	CCDC28A	6	139094928	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	11	139094928	32020139	659	12356										
CITED2	10370	broad.mit.edu	37	chr6	139694349	139694349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttttgccccagccagagttCgggcagctccttgatgcggt	13	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:139694349C>T	uc003qip.1	-	2	977	c.733G>A	c.(733-735)GAA>AAA	p.E245K		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	245	Asp/Glu-rich (acidic).			Missing: Inhibits transactivation activity.	adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		AGCCAGAGTTCGGGCAGCTCC	0.512													0	0	0	0.003755	0	36	121										T	139694349	C	T	139694349	3	4	46	1	0	0	0	0	1	0	0	0	3440	893	31	1	83	1	CITED2	6	139694349	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	599421	139694349	31420718	660	12357										
UTRN	7402	broad.mit.edu	37	chr6	144759888	144759888	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccccacggacaggctgcacGatgtgctgatggaactgcag	13	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:144759888G>A	uc003qkt.2	+	11	1341	c.1249G>A	c.(1249-1251)GAT>AAT	p.D417N	UTRN_uc010khq.1_Missense_Mutation_p.D417N	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	417	Interaction with SYNM.|Spectrin 2.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CAGGCTGCACGATGTGCTGAT	0.517													0	0	0	0.009535	0	30	79										A	144759888	G	A	144759888	3	1	46	1	0	0	0	0	1	0	0	0	17100	1058	37	1	1291	1	UTRN	6	144759888	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5065539	144759888	26355179	661	12358										
UTRN	7402	broad.mit.edu	37	chr6	144820495	144820495	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggctttctgctactgaaactGaattggtacagaagtccact	9	9	1	3	rs142782123		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:144820495G>A	uc003qkt.2	+	33	4788	c.4696G>A	c.(4696-4698)GAA>AAA	p.E1566K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1566	Interaction with SYNM.|Spectrin 11.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TACTGAAACTGAATTGGTACA	0.448													0	0	0	0.003954	0	26	41										A	144820495	G	A	144820495	3	1	46	1	0	0	0	0	1	0	0	0	17100	1291	45	1	4826	1	UTRN	6	144820495	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	60607	144820495	26294572	662	12359										
UTRN	7402	broad.mit.edu	37	chr6	145160371	145160371	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctcctcagcattctgcactGagctactcgcttgatccaga	7	14	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:145160371G>A	uc003qkt.2	+	71	10220	c.10128G>A	c.(10126-10128)CTG>CTA	p.L3376L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3376					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATTCTGCACTGAGCTACTCGC	0.537													0	0	0	0.008361	0	28	60										A	145160371	G	A	145160371	2	1	46	1	0	0	0	0	0	0	0	1	17100	1277	45	1		1	UTRN	6	145160371	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	339876	145160371	25954696	663	12360										
SASH1	23328	broad.mit.edu	37	chr6	148855934	148855934	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggatatgaagatttggacacCtttaagctgctggaggagga	14	5	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:148855934C>G	uc003qme.1	+	16	2467	c.1992C>G	c.(1990-1992)ACC>ACG	p.T664T	SASH1_uc011eeb.1_Silent_p.T425T|SASH1_uc003qmf.1_Silent_p.T74T	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	664	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATTTGGACACCTTTAAGCTGC	0.488													0	0	0	0.01441	0	71	86										G	148855934	C	G	148855934	2	3	46	1	0	0	0	0	0	0	0	1	13848	668	24	4		4	SASH1	6	148855934	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3695563	148855934	22259133	664	12361										
TAB2	23118	broad.mit.edu	37	chr6	149700055	149700055	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaacttgaacccccacaaaGaaataattcttcaaaactgc	3	12	2	2	rs1053435		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:149700055G>C	uc003qmj.2	+	3	1182	c.1004G>C	c.(1003-1005)AGA>ACA	p.R335T	TAB2_uc011eec.1_Missense_Mutation_p.R303T|TAB2_uc010kia.1_Missense_Mutation_p.R335T|TAB2_uc010kib.1_Missense_Mutation_p.R335T|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	335					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						CCCCCACAAAGAAATAATTCT	0.418													0	0	0	0.012213	0	31	48										C	149700055	G	C	149700055	3	2	46	1	0	0	0	0	1	0	0	0	15493	942	33	1	1010	1	TAB2	6	149700055	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	844121	149700055	21415012	665	12362										
RMND1	55005	broad.mit.edu	37	chr6	151754317	151754318	+	Missense_Mutation	DNP	CC	CC	AA													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaatattgttccaggatcaCcttcttttgcagaattttcc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:151754317_151754318CC>AA	uc003qoi.2	-	4	841_842	c.661_662GG>TT	c.(661-663)GGT>TTT	p.G221F	RMND1_uc011eeq.1_Missense_Mutation_p.G10F	NM_017909	NP_060379	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog	221											0		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		TCCAGGATCACCTTCTTTTGCA	0.381													0	0	0	0.004672	0	13	58										AA	151754318	CC	AA	151754317	3	1	46	1	0	0	0	0	1	0	0	0	13396	507	18	4	723	4	RMND1	6	151754317	Missense_Mutation	DNP	CC	TCGA-DK-A1AC-01A-11D-A13W-08	2054262	151754317	19360750	666	12363										
SYNE1	23345	broad.mit.edu	37	chr6	152831425	152831425	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttggtgggctgggagtctCagagctaactatgctgtcca	13	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:152831425C>T	uc010kiw.2	-	8	1086	c.484G>A	c.(484-486)GAG>AAG	p.E162K	SYNE1_uc003qot.3_Missense_Mutation_p.E169K|SYNE1_uc003qou.3_Missense_Mutation_p.E162K|SYNE1_uc010kjb.1_Missense_Mutation_p.E162K|SYNE1_uc003qpa.1_Missense_Mutation_p.E162K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	162	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGGAGTCTCAGAGCTAACT	0.498										HNSCC(10;0.0054)			0	0	0	0.01441	0	63	84										T	152831425	C	T	152831425	3	4	46	1	0	0	0	0	1	0	0	0	15442	835	29	1	26538	1	SYNE1	6	152831425	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1077108	152831425	18283642	667	12364										
RBM16	22828	broad.mit.edu	37	chr6	155129288	155129288	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggagtagtcagcagcattttCttgaacctgaagtcaatttg	10	7	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:155129288C>T	uc003qqa.2	+	11	1298	c.1066C>T	c.(1066-1068)CTT>TTT	p.L356F	RBM16_uc011efj.1_Missense_Mutation_p.L422F|RBM16_uc011efk.1_Missense_Mutation_p.L401F|RBM16_uc003qpz.2_Missense_Mutation_p.L356F|RBM16_uc010kji.2_Missense_Mutation_p.L377F	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	356	Gln-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		GCAGCATTTTCTTGAACCTGA	0.388													0	0	0	0.003954	0	25	98										T	155129288	C	T	155129288	3	4	46	1	0	0	0	0	1	0	0	0	13118	913	32	1	1104	1	RBM16	6	155129288	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2297863	155129288	15985779	668	12365										
RBM16	22828	broad.mit.edu	37	chr6	155143463	155143463	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagagacggtccagacaactCagagcccaactccagttgaa	9	12	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:155143463C>T	uc003qqa.2	+	17	2078	c.1846C>T	c.(1846-1848)CAG>TAG	p.Q616*	RBM16_uc011efj.1_Nonsense_Mutation_p.Q682*|RBM16_uc011efk.1_Nonsense_Mutation_p.Q661*|RBM16_uc003qpz.2_Nonsense_Mutation_p.Q616*|RBM16_uc010kji.2_Nonsense_Mutation_p.Q637*	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	616					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CCAGACAACTCAGAGCCCAAC	0.448													0	0	0	0.01441	0	62	120										T	155143463	C	T	155143463	4	4	46	1	0	0	0	0	0	1	0	0	13118	827	29	1	1908	1	RBM16	6	155143463	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	14175	155143463	15971604	669	12366										
TULP4	56995	broad.mit.edu	37	chr6	158924726	158924726	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccggaagcgcctggacagccGagcagaagaaggcagcgttc	15	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:158924726G>A	uc003qrf.2	+	13	5388	c.4031G>A	c.(4030-4032)CGA>CAA	p.R1344Q	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1344					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CTGGACAGCCGAGCAGAAGAA	0.537													0	0	0	0.004482	0	9	47										A	158924726	G	A	158924726	3	1	46	1	0	0	0	0	1	0	0	0	16773	1058	37	1	4081	1	TULP4	6	158924726	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3781263	158924726	12190341	670	12367										
TMEM181	57583	broad.mit.edu	37	chr6	159052907	159052907	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccaagtacaaggaggagtCagatagtgactgagccccgg	15	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159052907C>T	uc003qrm.3	+	17	1837	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	609					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		AAGGAGGAGTCAGATAGTGAC	0.557													0	0	0	0.004672	0	3	4										T	159052907	C	T	159052907	3	4	46	1	0	0	0	0	1	0	0	0	16097	838	29	1	1892	1	TMEM181	6	159052907	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	128181	159052907	12062160	671	12368										
SYTL3	94120	broad.mit.edu	37	chr6	159173048	159173048	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaccgtggacccgacctttCaggagaccttgaaggtactt	10	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159173048C>T	uc003qrp.2	+	12	1367	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	SYTL3_uc011efp.1_Nonsense_Mutation_p.Q375*|SYTL3_uc003qro.2_Nonsense_Mutation_p.Q307*|SYTL3_uc003qrq.2_Nonsense_Mutation_p.Q307*|SYTL3_uc003qrr.2_Nonsense_Mutation_p.Q375*|SYTL3_uc003qrs.2_Nonsense_Mutation_p.Q307*|SYTL3_uc011efq.1_Nonsense_Mutation_p.Q101*	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	375	C2 1.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CCCGACCTTTCAGGAGACCTT	0.577													0	0	0	0.000602	0	5	29										T	159173048	C	T	159173048	4	4	46	1	0	0	0	0	0	1	0	0	15481	827	29	1	949	1	SYTL3	6	159173048	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	120141	159173048	11942019	672	12369										
EZR	7430	broad.mit.edu	37	chr6	159204664	159204664	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccatacatttccaggtcctGagcaatcttcaggtattcca	6	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159204664G>A	uc003qrt.3	-	6	801	c.586C>T	c.(586-588)CAG>TAG	p.Q196*	EZR_uc011efs.1_Nonsense_Mutation_p.Q164*|EZR_uc003qru.3_Nonsense_Mutation_p.Q196*	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	196	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCCAGGTCCTGAGCAATCTTC	0.393													0	0	0	0.004656	0	28	106										A	159204664	G	A	159204664	4	1	46	1	0	0	0	0	0	1	0	0	5335	1299	45	1	1206	1	EZR	6	159204664	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	31616	159204664	11910403	673	12370										
FNDC1	84624	broad.mit.edu	37	chr6	159677592	159677592	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatcctatgaagacttcatCaggaacaagtggtccactca	8	11	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159677592C>T	uc010kjv.2	+	18	5303	c.5103C>T	c.(5101-5103)ATC>ATT	p.I1701I		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1701	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AAGACTTCATCAGGAACAAGT	0.423													0	0	0	0.01441	0	62	173										T	159677592	C	T	159677592	2	4	46	1	0	0	0	0	0	0	0	1	5968	816	29	1		1	FNDC1	6	159677592	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	472928	159677592	11437475	674	12371										
FNDC1	84624	broad.mit.edu	37	chr6	159677606	159677606	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcatcaggaacaagtggtCcactcaagcttcatcagtaa	7	11	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159677606C>G	uc010kjv.2	+	18	5317	c.5117C>G	c.(5116-5118)TCC>TGC	p.S1706C		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1706	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AACAAGTGGTCCACTCAAGCT	0.433													0	0	0	0.01441	0	65	168										G	159677606	C	G	159677606	3	3	46	1	0	0	0	0	1	0	0	0	5968	855	30	1	5187	1	FNDC1	6	159677606	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	14	159677606	11437461	675	12372										
IGF2R	3482	broad.mit.edu	37	chr6	160500612	160500612	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacgcatggtttttgtccagGtgactcgcgactcgcgcacc	11	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:160500612G>C	uc003qta.2	+	38	5627	c.5479G>C	c.(5479-5481)GTG>CTG	p.V1827L		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1827	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TTTTGTCCAGGTGACTCGCGA	0.577													0	0	0	0.004672	0	3	11										C	160500612	G	C	160500612	3	2	46	1	0	0	0	0	1	0	0	0	7576	1275	44	4	5629	4	IGF2R	6	160500612	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	823006	160500612	10614455	676	12373										
LPA	4018	broad.mit.edu	37	chr6	160998217	160998217	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgccagtgtggtatcatagAtgaccaagattgacaggtcc	11	8	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:160998217A>G	uc003qtl.2	-	29	4702	c.4582T>C	c.(4582-4584)TCT>CCT	p.S1528P		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4036	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGTATCATAGATGACCAAGAT	0.463													0	0	0	0.004878	0	37	144										G	160998217	A	G	160998217	3	3	46	1	0	0	0	0	1	0	0	0	8903	333	12	5	1588	5	LPA	6	160998217	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	497605	160998217	10116850	677	12374										
MLLT4	4301	broad.mit.edu	37	chr6	168352586	168352586	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctttcctcgggggacagtCtgtcccccgacccgtggaag	13	14	1	0	rs141139097		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:168352586C>T	uc003qwd.2	+	29	4670	c.4528C>T	c.(4528-4530)CTG>TTG	p.L1510L	MLLT4_uc003qwb.1_Silent_p.L1495L|MLLT4_uc003qwc.1_Silent_p.L1511L|MLLT4_uc003qwg.1_Silent_p.L820L	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1511					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGGGGACAGTCTGTCCCCCGA	0.602			T	MLL	AL								0	0	0	0.004656	0	24	29										T	168352586	C	T	168352586	2	4	46	1	0	0	0	0	0	0	0	1	9629	912	32	1		1	MLLT4	6	168352586	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7354369	168352586	2762481	678	12375										
THBS2	7058	broad.mit.edu	37	chr6	169629759	169629759	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctgcccagaatttggcaGatgggggcagttatcctgca	12	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:169629759G>C	uc003qwt.2	-	15	2415	c.2167C>G	c.(2167-2169)CTG>GTG	p.L723V		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	723	TSP type-3 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GAATTTGGCAGATGGGGGCAG	0.483													0	0	0	0.00278	0	22	97										C	169629759	G	C	169629759	3	2	46	1	0	0	0	0	1	0	0	0	15851	933	33	1	1387	1	THBS2	6	169629759	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1277173	169629759	1485308	679	12376										
CARD11	84433	broad.mit.edu	37	chr7	2966391	2966391	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accatccagatctaaggcgtCaaacccgccgctgtcattgt	8	14	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:2966391C>T	uc003smv.2	-	14	2193	c.1789G>A	c.(1789-1791)GAC>AAC	p.D597N		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	597					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCTAAGGCGTCAAACCCGCCG	0.577			Mis		DLBCL								0	0	0	0.009096	0	4	11										T	2966391	C	T	2966391	3	4	46	1	0	0	0	0	1	0	0	0	2645	826	29	1	1723	1	CARD11	7	2966391	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		2966391	156172272	680	12377										
CARD11	84433	broad.mit.edu	37	chr7	2966418	2966418	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccgctgtcattgtcttcttCgactgtgctgcaagacacaa	9	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:2966418C>T	uc003smv.2	-	14	2166	c.1762G>A	c.(1762-1764)GAA>AAA	p.E588K		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	588					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGTCTTCTTCGACTGTGCTG	0.567			Mis		DLBCL								0	0	0	0.001168	0	5	12										T	2966418	C	T	2966418	3	4	46	1	0	0	0	0	1	0	0	0	2645	893	31	1	1750	1	CARD11	7	2966418	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	27	2966418	156172245	681	12378										
RNF216	54476	broad.mit.edu	37	chr7	5780687	5780687	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttttccaaattgggctcttGagattcttgcattggaaagg	11	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:5780687G>C	uc003soy.1	-	4	980	c.790C>G	c.(790-792)CAA>GAA	p.Q264E	RNF216_uc010ksz.1_5'UTR|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Missense_Mutation_p.Q321E	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	264					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TTGGGCTCTTGAGATTCTTGC	0.453													0	0	0	0.012213	0	32	108										C	5780687	G	C	5780687	3	2	46	1	0	0	0	0	1	0	0	0	13480	1299	45	1	1866	1	RNF216	7	5780687	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2814269	5780687	153357976	682	12379										
ARL4A	10124	broad.mit.edu	37	chr7	12728246	12728246	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaaaataactaggatatcaGaaaatcagggagtccctgta	8	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:12728246G>A	uc003ssp.2	+	2	644	c.367G>A	c.(367-369)GAA>AAA	p.E123K	ARL4A_uc003ssq.2_Missense_Mutation_p.E123K|ARL4A_uc003ssr.2_Missense_Mutation_p.E123K|ARL4A_uc003sss.2_Missense_Mutation_p.E123K	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	123					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		TAGGATATCAGAAAATCAGGG	0.378													0	0	0	0.013537	0	11	78										A	12728246	G	A	12728246	3	1	46	1	0	0	0	0	1	0	0	0	936	943	33	1	369	1	ARL4A	7	12728246	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6947559	12728246	146410417	683	12380										
ETV1	2115	broad.mit.edu	37	chr7	13975376	13975376	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctggtatggactgcgatgGagggaggtgagctgggaagg	20	4	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:13975376G>C	uc011jxq.1	-	8	1250	c.511C>G	c.(511-513)CCA>GCA	p.P171A	ETV1_uc011jxn.1_Missense_Mutation_p.P131A|ETV1_uc011jxo.1_Intron|ETV1_uc011jxp.1_Missense_Mutation_p.P113A|ETV1_uc003ssw.3_Missense_Mutation_p.P171A|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.P153A|ETV1_uc011jxs.1_Missense_Mutation_p.P153A|ETV1_uc010ktv.2_Missense_Mutation_p.P40A	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	171					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GACTGCGATGGAGGGAGGTGA	0.512			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								0	0	0	0.009535	0	30	176										C	13975376	G	C	13975376	3	2	46	1	0	0	0	0	1	0	0	0	5277	1174	41	1	950	1	ETV1	7	13975376	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1247130	13975376	145163287	684	12381										
TMEM195	392636	broad.mit.edu	37	chr7	15601351	15601351	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caataaagtctcacctttttTacataatcaggcacctcttc	3	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:15601351T>C	uc003stb.1	-	1	290	c.120A>G	c.(118-120)GTA>GTG	p.V40V		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	40					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TCACCTTTTTTACATAATCAG	0.373													0	0	0	0.003271	0	30	127										C	15601351	T	C	15601351	2	2	46	1	0	0	0	0	0	0	0	1	16114	1741	61	5		5	TMEM195	7	15601351	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1625975	15601351	143537312	685	12382										
AGR2	10551	broad.mit.edu	37	chr7	16840963	16840963	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttgtcttggatttatataGagcttcttcatatgtctgag	8	7	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:16840963G>A	uc003str.2	-	3	371	c.184C>T	c.(184-186)CTA>TTA	p.L62L	AGR2_uc011jxy.1_3'UTR	NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	62					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		GATTTATATAGAGCTTCTTCA	0.388													0	0	0	0.00245	0	14	55										A	16840963	G	A	16840963	2	1	46	1	0	0	0	0	0	0	0	1	395	933	33	1		1	AGR2	7	16840963	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1239612	16840963	142297700	686	12383										
HDAC9	9734	broad.mit.edu	37	chr7	18705862	18705862	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgaaatctattgaacaactGaagcaaccaggcagtcacct	7	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:18705862G>A	uc003suh.2	+	11	1526	c.1485G>A	c.(1483-1485)CTG>CTA	p.L495L	HDAC9_uc003sue.2_Silent_p.L495L|HDAC9_uc011jyd.1_Silent_p.L495L|HDAC9_uc003sui.2_Silent_p.L498L|HDAC9_uc003suj.2_Silent_p.L454L|HDAC9_uc011jya.1_Silent_p.L492L|HDAC9_uc003sua.1_Silent_p.L473L|HDAC9_uc011jyb.1_Silent_p.L451L|HDAC9_uc003sud.1_Silent_p.L495L|HDAC9_uc011jyc.1_Silent_p.L454L|HDAC9_uc003suf.1_Silent_p.L526L|HDAC9_uc010kud.1_Silent_p.L498L|HDAC9_uc011jye.1_Silent_p.L467L|HDAC9_uc011jyf.1_Silent_p.L418L|HDAC9_uc010kue.1_Intron	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	495					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TTGAACAACTGAAGCAACCAG	0.473											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	36	133										A	18705862	G	A	18705862	2	1	46	1	0	0	0	0	0	0	0	1	7014	1277	45	1		1	HDAC9	7	18705862	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1864899	18705862	140432801	687	12384										
NUPL2	11097	broad.mit.edu	37	chr7	23240239	23240239	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagcagcatcattgcaacaGataatgtgttattcacaccc	6	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:23240239G>C	uc003svu.2	+	7	1406	c.1147G>C	c.(1147-1149)GAT>CAT	p.D383H	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Missense_Mutation_p.D260H|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Missense_Mutation_p.D260H|NUPL2_uc011jyx.1_Missense_Mutation_p.D155H	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	383	Interaction with GLE1.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						CATTGCAACAGATAATGTGTT	0.393													0	0	0	0.00632	0	28	174										C	23240239	G	C	23240239	3	2	46	1	0	0	0	0	1	0	0	0	10775	942	33	1	1173	1	NUPL2	7	23240239	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4534377	23240239	135898424	688	12385										
C7orf41	222166	broad.mit.edu	37	chr7	30174846	30174846	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggagaccgaacgcaggatgGatttctacgccgaccccggc	13	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:30174846G>A	uc011kab.1	+	1	295	c.94G>A	c.(94-96)GAT>AAT	p.D32N	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Missense_Mutation_p.D32N	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	32											0						ACGCAGGATGGATTTCTACGC	0.597													0	0	0	0.004672	0	3	13										A	30174846	G	A	30174846	3	1	46	1	0	0	0	0	1	0	0	0	2391	1174	41	1	96	1	C7orf41	7	30174846	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6934607	30174846	128963817	689	12386										
EEPD1	80820	broad.mit.edu	37	chr7	36327382	36327382	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagaccctacaggaaaccctGaaaggtaggacattgtcttt	9	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:36327382G>A	uc003tfa.2	+	6	1951	c.1311G>A	c.(1309-1311)CTG>CTA	p.L437L		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	437					DNA repair		DNA binding				0						AGGAAACCCTGAAAGGTAGGA	0.567													0	0	0	0.01441	0	44	78										A	36327382	G	A	36327382	2	1	46	1	0	0	0	0	0	0	0	1	4932	1277	45	1		1	EEPD1	7	36327382	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6152536	36327382	122811281	690	12387										
PSMA2	5683	broad.mit.edu	37	chr7	42964297	42964297	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gactgagtatattcttgcatCacagaagctactctctgtac	7	10	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:42964297C>T	uc003thy.2	-	4	399	c.351G>A	c.(349-351)GTG>GTA	p.V117V	C7orf25_uc010kxr.2_5'UTR|PSMA2_uc010kxt.2_Silent_p.V39V|PSMA2_uc003thz.1_Silent_p.V39V	NM_002787	NP_002778	P25787	PSA2_HUMAN	proteasome subunit alpha type 2	117					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			large_intestine(2)|ovary(1)	3						ATTCTTGCATCACAGAAGCTA	0.393													0	0	0	0.005443	0	27	131										T	42964297	C	T	42964297	2	4	46	1	0	0	0	0	0	0	0	1	12667	813	29	1		1	PSMA2	7	42964297	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6636915	42964297	116174366	691	12388										
HECW1	23072	broad.mit.edu	37	chr7	43540819	43540819	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttcatatgcagtctctttGaagaagagattatgtcctac	7	7	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:43540819G>A	uc003tid.1	+	21	4134	c.3529G>A	c.(3529-3531)GAA>AAA	p.E1177K	HECW1_uc011kbi.1_Missense_Mutation_p.E1143K	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1177					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGTCTCTTTGAAGAAGAGAT	0.423													0	0	0	0.001855	0	14	63										A	43540819	G	A	43540819	3	1	46	1	0	0	0	0	1	0	0	0	7042	1291	45	1	3603	1	HECW1	7	43540819	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	576522	43540819	115597844	692	12389										
NPC1L1	29881	broad.mit.edu	37	chr7	44573037	44573037	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagctgcccctacctcctgcCtcttgctgtccagggagagc	10	17	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:44573037C>T	uc003tlb.2	-	8	2458	c.2402G>A	c.(2401-2403)AGG>AAG	p.R801K	NPC1L1_uc003tlc.2_Missense_Mutation_p.R801K|NPC1L1_uc011kbw.1_Missense_Mutation_p.R801K|NPC1L1_uc003tld.2_3'UTR	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	801	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	TACCTCCTGCCTCTTGCTGTC	0.622													0	0	0	0.007291	0	29	40										T	44573037	C	T	44573037	3	4	46	1	0	0	0	0	1	0	0	0	10571	681	24	2	1729	2	NPC1L1	7	44573037	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1032218	44573037	114565626	693	12390										
COBL	23242	broad.mit.edu	37	chr7	51095844	51095844	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccacagaaacacgatccctCtgggaagactgaaccagtga	9	13	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:51095844C>T	uc003tpr.3	-	10	3134	c.2949G>A	c.(2947-2949)CAG>CAA	p.Q983Q	COBL_uc003tps.2_Silent_p.Q1040Q|COBL_uc011kcl.1_Silent_p.Q983Q|COBL_uc003tpp.3_Silent_p.Q769Q|COBL_uc003tpq.3_Silent_p.Q924Q|COBL_uc003tpo.3_Silent_p.Q525Q	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	983										skin(3)|ovary(2)	5	Glioma(55;0.08)					CACGATCCCTCTGGGAAGACT	0.557													0	0	0	0.004007	0	16	62										T	51095844	C	T	51095844	2	4	46	1	0	0	0	0	0	0	0	1	3653	912	32	1		1	COBL	7	51095844	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6522807	51095844	108042819	694	12391										
VSTM2A	222008	broad.mit.edu	37	chr7	54612455	54612455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggggccggaggacctggatCccggggccgagggggccggc	23	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:54612455C>T	uc010kzf.2	+	2	625	c.220C>T	c.(220-222)CCC>TCC	p.P74S	VSTM2A_uc010kze.2_Missense_Mutation_p.P74S|VSTM2A_uc003tqc.3_Missense_Mutation_p.P74S	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	74	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			GGACCTGGATCCCGGGGCCGA	0.736													0	0	0	0.001984	0	7	14										T	54612455	C	T	54612455	3	4	46	1	0	0	0	0	1	0	0	0	17226	855	30	1	226	1	VSTM2A	7	54612455	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3516611	54612455	104526208	695	12392										
SUMF2	25870	broad.mit.edu	37	chr7	56141885	56141885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtctgtactctggtggcttCcagtggaaaaggcattttgg	13	7	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:56141885C>T	uc003trv.2	+	4	446	c.415C>T	c.(415-417)CCA>TCA	p.P139S	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Missense_Mutation_p.P139S|SUMF2_uc011kcx.1_Missense_Mutation_p.P139S|SUMF2_uc003trt.2_Missense_Mutation_p.P32S|SUMF2_uc011kcy.1_Intron|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	120						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTGGTGGCTTCCAGTGGAAAA	0.552											OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.011902	0	41	164										T	56141885	C	T	56141885	3	4	46	1	0	0	0	0	1	0	0	0	15383	855	30	1	429	1	SUMF2	7	56141885	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1529430	56141885	102996778	696	12393										
SUMF2	25870	broad.mit.edu	37	chr7	56141899	56141899	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcttccagtggaaaaggcAttttggaggcaggtaagggc	16	6	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:56141899A>G	uc003trv.2	+	4	460	c.429A>G	c.(427-429)GCA>GCG	p.A143A	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Silent_p.A143A|SUMF2_uc011kcx.1_Silent_p.A143A|SUMF2_uc003trt.2_Silent_p.A36A|SUMF2_uc011kcy.1_Intron|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	124						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGGAAAAGGCATTTTGGAGGC	0.552											OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006999	0	37	156										G	56141899	A	G	56141899	2	3	46	1	0	0	0	0	0	0	0	1	15383	204	8	5		5	SUMF2	7	56141899	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	14	56141899	102996764	697	12394										
SUMF2	25870	broad.mit.edu	37	chr7	56142308	56142308	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctggctctggcatccgagaGagactggagcacccagtgtt	13	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:56142308G>A	uc003trv.2	+	5	502	c.471G>A	c.(469-471)GAG>GAA	p.E157E	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Silent_p.E157E|SUMF2_uc011kcx.1_Intron|SUMF2_uc003trt.2_Silent_p.E50E|SUMF2_uc011kcy.1_Silent_p.E142E|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_Intron|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	138						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GCATCCGAGAGAGACTGGAGC	0.597											OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	14	96										A	56142308	G	A	56142308	2	1	46	1	0	0	0	0	0	0	0	1	15383	933	33	1		1	SUMF2	7	56142308	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	409	56142308	102996355	698	12395										
ASL	435	broad.mit.edu	37	chr7	65554627	65554627	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaagctgtgtttgaagtgtCagacactatgagtgccgtgc	14	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:65554627C>G	uc003tuo.2	+	14	1118	c.1007C>G	c.(1006-1008)TCA>TGA	p.S336*	ASL_uc003tup.2_Nonsense_Mutation_p.S336*|ASL_uc003tur.2_Nonsense_Mutation_p.S310*|ASL_uc003tuq.2_Nonsense_Mutation_p.S316*	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	336					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	TTTGAAGTGTCAGACACTATG	0.642													0	0	0	0.003163	0	14	53										G	65554627	C	G	65554627	4	3	46	1	0	0	0	0	0	1	0	0	1044	838	29	1	1057	1	ASL	7	65554627	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9412319	65554627	93584036	699	12396										
SBDS	51119	broad.mit.edu	37	chr7	66456253	66456253	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtgagcacgttctatcttCattttctcttttaactgctt	5	9	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:66456253C>T	uc003tvm.1	-	4	679	c.495G>A	c.(493-495)ATG>ATA	p.M165I		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	165					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						GTTCTATCTTCATTTTCTCTT	0.368			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				0	0	0	0.00632	0	25	55										T	66456253	C	T	66456253	3	4	46	1	0	0	0	0	1	0	0	0	13857	826	29	1	265	1	SBDS	7	66456253	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	901626	66456253	92682410	700	12397										
STAG3L4	64940	broad.mit.edu	37	chr7	66771042	66771042	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggatttctggagcttgttaaCtttttcatctgatcttgtgg	10	6	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:66771042C>G	uc003tvt.3	+	2	326	c.59C>G	c.(58-60)ACT>AGT	p.T20S	STAG3L4_uc010laj.2_RNA	NM_022906	NP_075057	Q8TBR4	STG34_HUMAN	stromal antigen 3-like 4	20											0		Lung NSC(55;0.0839)|all_lung(88;0.181)				AGCTTGTTAACTTTTTCATCT	0.368													0	0	0	0.009718	0	40	201										G	66771042	C	G	66771042	3	3	46	1	0	0	0	0	1	0	0	0	15246	565	20	4	61	4	STAG3L4	7	66771042	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	314789	66771042	92367621	701	12398										
WBSCR22	114049	broad.mit.edu	37	chr7	73107716	73107716	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctccggtggcatggtggtaGactaccctaacagtgccaaa	11	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:73107716G>T	uc003tyt.2	+	8	626	c.568G>T	c.(568-570)GAC>TAC	p.D190Y	WBSCR22_uc010lbi.1_RNA|WBSCR22_uc003tyu.2_Missense_Mutation_p.D190Y|WBSCR22_uc003tyv.2_Missense_Mutation_p.D152Y|WBSCR22_uc003tyw.1_Missense_Mutation_p.D53Y	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	190						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CATGGTGGTAGACTACCCTAA	0.602													1	0	0.00198382	0.001984	0.00201257	7	12										T	73107716	G	T	73107716	3	4	46	1	0	0	0	0	1	0	0	0	17262	942	33	3	598	3	WBSCR22	7	73107716	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6336674	73107716	86030947	702	12399										
TMEM120A	83862	broad.mit.edu	37	chr7	75617097	75617097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggcggtagaggcagccgctCtggtagtagtactggagaaa	16	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:75617097C>G	uc003ued.2	-	10	827	c.723G>C	c.(721-723)CAG>CAC	p.Q241H	TMEM120A_uc003uee.2_Missense_Mutation_p.E180Q|TMEM120A_uc003ueb.1_Missense_Mutation_p.Q27H|TMEM120A_uc003uec.2_Missense_Mutation_p.Q145H	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	241	Cytoplasmic (Potential).					integral to membrane					0						GGCAGCCGCTCTGGTAGTAGT	0.687													0	0	0	0.009096	0	3	8										G	75617097	C	G	75617097	3	3	46	1	0	0	0	0	1	0	0	0	16030	912	32	1	324	1	TMEM120A	7	75617097	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2509381	75617097	83521566	703	12400										
PTPN12	5782	broad.mit.edu	37	chr7	77247848	77247848	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccatagagcctgaaaaacaaGattctcctcctccaaaacca	4	14	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:77247848G>A	uc003ugh.2	+	12	1082	c.991G>A	c.(991-993)GAT>AAT	p.D331N	PTPN12_uc011kgp.1_Missense_Mutation_p.D212N|PTPN12_uc011kgq.1_Missense_Mutation_p.D201N|PTPN12_uc010lds.2_Missense_Mutation_p.D63N	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	331						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						TGAAAAACAAGATTCTCCTCC	0.348													0	0	0	0.003271	0	34	99										A	77247848	G	A	77247848	3	1	46	1	0	0	0	0	1	0	0	0	12781	942	33	1	1037	1	PTPN12	7	77247848	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1630751	77247848	81890815	704	12401										
PHTF2	57157	broad.mit.edu	37	chr7	77539723	77539723	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatgctgctttctttttatCagggtttgtatttatttaag	8	5	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:77539723C>G	uc003ugs.3	+	8	899	c.773C>G	c.(772-774)TCA>TGA	p.S258*	PHTF2_uc003ugo.3_Nonsense_Mutation_p.S220*|PHTF2_uc003ugp.2_Nonsense_Mutation_p.S220*|PHTF2_uc003ugq.3_Nonsense_Mutation_p.S220*|PHTF2_uc010ldv.2_Nonsense_Mutation_p.S220*|PHTF2_uc003ugr.3_Nonsense_Mutation_p.S224*|PHTF2_uc003ugt.3_Nonsense_Mutation_p.S224*|PHTF2_uc003ugu.3_Nonsense_Mutation_p.S220*|PHTF2_uc003ugv.2_Nonsense_Mutation_p.S83*|PHTF2_uc010ldw.1_Nonsense_Mutation_p.S83*	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						TTCTTTTTATCAGGGTTTGTA	0.398													0	0	0	0.006122	0	17	21										G	77539723	C	G	77539723	4	3	46	1	0	0	0	0	0	1	0	0	11863	838	29	1	697	1	PHTF2	7	77539723	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	291875	77539723	81598940	705	12402										
MAGI2	9863	broad.mit.edu	37	chr7	78130895	78130895	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaaatgtgtgaaactcactCaatgaagtagacttcgccct	8	9	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:78130895C>G	uc003ugx.2	-	5	1218	c.964G>C	c.(964-966)GAC>CAC	p.D322H	MAGI2_uc003ugy.2_Missense_Mutation_p.D322H|MAGI2_uc011kgr.1_Missense_Mutation_p.D154H|MAGI2_uc011kgs.1_Missense_Mutation_p.D159H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	322	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GAAACTCACTCAATGAAGTAG	0.383													0	0	0	0.006122	0	17	74										G	78130895	C	G	78130895	3	3	46	1	0	0	0	0	1	0	0	0	9191	840	29	1	3475	1	MAGI2	7	78130895	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	591172	78130895	81007768	706	12403										
PCLO	27445	broad.mit.edu	37	chr7	82582282	82582282	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaactgtgtaactgatgtggGagctgcttgaaatgaagagg	14	4	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:82582282G>C	uc003uhx.2	-	5	8276	c.7987C>G	c.(7987-7989)CCC>GCC	p.P2663A	PCLO_uc003uhv.2_Missense_Mutation_p.P2663A|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2594					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTGATGTGGGAGCTGCTTGA	0.443													0	0	0	0.00874	0	35	24										C	82582282	G	C	82582282	3	2	46	1	0	0	0	0	1	0	0	0	11583	1174	41	1	7542	1	PCLO	7	82582282	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4451387	82582282	76556381	707	12404										
SEMA3D	223117	broad.mit.edu	37	chr7	84702367	84702367	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgagttttgttatagggctGaagtactctgatgaaatttg	12	3	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:84702367G>A	uc003uic.2	-	4	446	c.406C>T	c.(406-408)CAG>TAG	p.Q136*	SEMA3D_uc010led.2_Nonsense_Mutation_p.Q136*|SEMA3D_uc010lee.1_Nonsense_Mutation_p.Q136*	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	136	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TTATAGGGCTGAAGTACTCTG	0.348													0	0	0	0.012319	0	20	61										A	84702367	G	A	84702367	4	1	46	1	0	0	0	0	0	1	0	0	14027	1299	45	1	1983	1	SEMA3D	7	84702367	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2120085	84702367	74436296	708	12405										
STEAP4	79689	broad.mit.edu	37	chr7	87912268	87912268	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttcataaacataagggtaGattacgtctcttataacaca	5	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:87912268G>C	uc003ujs.2	-	3	777	c.672C>G	c.(670-672)ATC>ATG	p.I224M	STEAP4_uc010lek.2_Intron|STEAP4_uc003ujt.2_Missense_Mutation_p.I224M	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	224					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CATAAGGGTAGATTACGTCTC	0.383													0	0	0	0.003163	0	15	75										C	87912268	G	C	87912268	3	2	46	1	0	0	0	0	1	0	0	0	15279	932	33	1	719	1	STEAP4	7	87912268	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3209901	87912268	71226395	709	12406										
ZNF804B	219578	broad.mit.edu	37	chr7	88965470	88965471	+	Frame_Shift_Ins	INS	-	-	ATCC													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaaacctttaattagtgaaINSatccaaccttttattcaaag							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:88965470_88965471insATCC	uc011khi.1	+	4	3712_3713	c.3174_3175insATCC	c.(3172-3177)GAAATCfs	p.E1058fs		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1058_1059						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TAATTAGTGAAATCCAACCTTT	0.356										HNSCC(36;0.09)								24	93	---	---								ATCC	88965471	-	ATCC	88965470	7	5	46	1	0	1	1	0	0	0	0	0	18168	11	1	0	3188	0	ZNF804B	7	88965470	Frame_Shift_Ins	INS	-	TCGA-DK-A1AC-01A-11D-A13W-08	1053202	88965470	70173193	710	12407										
STEAP2	261729	broad.mit.edu	37	chr7	89854699	89854699	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagaacattatacctccctGtgggacctgagacatctgct	9	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:89854699G>C	uc003ujz.2	+	2	696	c.303G>C	c.(301-303)CTG>CTC	p.L101L	STEAP2_uc003ujy.2_Silent_p.L143L|STEAP2_uc010len.2_Silent_p.L101L|STEAP2_uc003uka.2_Silent_p.L101L|STEAP2_uc003ukb.2_Silent_p.L101L|STEAP2_uc003ukc.2_Silent_p.L101L|STEAP2_uc003ukd.2_Silent_p.L101L	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	101					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					ATACCTCCCTGTGGGACCTGA	0.378													0	0	0	0.011902	0	45	158										C	89854699	G	C	89854699	2	2	46	1	0	0	0	0	0	0	0	1	15277	1364	48	4		4	STEAP2	7	89854699	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	889229	89854699	69283964	711	12408										
CDK14	5218	broad.mit.edu	37	chr7	90528612	90528612	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttttcttttctagcacactGatttatgtcagtacatggac	6	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:90528612G>A	uc003uky.2	+	7	868	c.646G>A	c.(646-648)GAT>AAT	p.D216N	CDK14_uc003ukz.1_Missense_Mutation_p.D198N|CDK14_uc010les.1_Missense_Mutation_p.D170N|CDK14_uc011khl.1_Missense_Mutation_p.D87N	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	216	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						CTAGCACACTGATTTATGTCA	0.363													0	0	0	0.013537	0	12	31										A	90528612	G	A	90528612	3	1	46	1	0	0	0	0	1	0	0	0	3130	1290	45	1	614	1	CDK14	7	90528612	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	673913	90528612	68610051	712	12409										
FZD1	8321	broad.mit.edu	37	chr7	90894810	90894810	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggcgctcatgaacaagttCggcttccagtggccagacac	12	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:90894810C>T	uc003ula.2	+	1	1028	c.615C>T	c.(613-615)TTC>TTT	p.F205F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	205	FZ.|Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGAACAAGTTCGGCTTCCAGT	0.692													0	0	0	0.001855	0	13	28										T	90894810	C	T	90894810	2	4	46	1	0	0	0	0	0	0	0	1	6128	883	31	1		1	FZD1	7	90894810	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	366198	90894810	68243853	713	12410										
AKAP9	10142	broad.mit.edu	37	chr7	91630771	91630771	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcaaaaggaaaaactcaagGaagaactaggactaatttta	7	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:91630771G>A	uc003ulg.2	+	8	1765	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K	AKAP9_uc003ule.2_Missense_Mutation_p.E526K|AKAP9_uc003ulf.2_Missense_Mutation_p.E514K|AKAP9_uc003uli.2_Missense_Mutation_p.E139K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	526	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAACTCAAGGAAGAACTAGG	0.333			T	BRAF	papillary thyroid								0	0	0	0.010504	0	21	83										A	91630771	G	A	91630771	3	1	46	1	0	0	0	0	1	0	0	0	459	1175	41	1	1570	1	AKAP9	7	91630771	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	735961	91630771	67507892	714	12411										
AKAP9	10142	broad.mit.edu	37	chr7	91690664	91690664	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtcccttaagtgccaagagGaacttcgagagcgccttcat	10	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:91690664G>A	uc003ulg.2	+	23	5917	c.5692G>A	c.(5692-5694)GAA>AAA	p.E1898K	AKAP9_uc003ulf.2_Missense_Mutation_p.E1898K|AKAP9_uc003uli.2_Missense_Mutation_p.E1521K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1910	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GTGCCAAGAGGAACTTCGAGA	0.483			T	BRAF	papillary thyroid								0	0	0	0.004289	0	37	40										A	91690664	G	A	91690664	3	1	46	1	0	0	0	0	1	0	0	0	459	1175	41	1	5782	1	AKAP9	7	91690664	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	59893	91690664	67447999	715	12412										
SAMD9L	219285	broad.mit.edu	37	chr7	92762320	92762320	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtacagggcaatcagagggtGaatgatacgcacacctgtgt	13	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:92762320G>A	uc003umh.1	-	5	4181	c.2965C>T	c.(2965-2967)CAC>TAC	p.H989Y	SAMD9L_uc003umj.1_Missense_Mutation_p.H989Y|SAMD9L_uc003umi.1_Missense_Mutation_p.H989Y|SAMD9L_uc010lfb.1_Missense_Mutation_p.H989Y|SAMD9L_uc003umk.1_Missense_Mutation_p.H989Y|SAMD9L_uc010lfc.1_Missense_Mutation_p.H989Y|SAMD9L_uc010lfd.1_Missense_Mutation_p.H989Y|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	989										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ATCAGAGGGTGAATGATACGC	0.358													0	0	0	0.007291	0	30	98										A	92762320	G	A	92762320	3	1	46	1	0	0	0	0	1	0	0	0	13827	1290	45	1	1793	1	SAMD9L	7	92762320	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1071656	92762320	66376343	716	12413										
PPP1R9A	55607	broad.mit.edu	37	chr7	94540505	94540505	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggaggcagcaaagcaacaGaggaaagaacttgcaggtgg	16	6	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:94540505G>A	uc003unp.2	+	2	1362	c.1080G>A	c.(1078-1080)CAG>CAA	p.Q360Q	PPP1R9A_uc010lfj.2_Silent_p.Q360Q|PPP1R9A_uc011kif.1_Silent_p.Q360Q|PPP1R9A_uc003unq.2_Silent_p.Q360Q|PPP1R9A_uc011kig.1_Silent_p.Q360Q	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	360						cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAAGCAACAGAGGAAAGAAC	0.438										HNSCC(28;0.073)			0	0	0	0.012213	0	34	26										A	94540505	G	A	94540505	2	1	46	1	0	0	0	0	0	0	0	1	12378	933	33	1		1	PPP1R9A	7	94540505	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1778185	94540505	64598158	717	12414										
TAC1	6863	broad.mit.edu	37	chr7	97362008	97362008	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataggagccaatgatgatctGaattactggtccgactggta	11	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:97362008G>A	uc003uop.3	+	2	330	c.84G>A	c.(82-84)CTG>CTA	p.L28L	TAC1_uc003uoq.3_Silent_p.L28L|TAC1_uc003uor.3_Silent_p.L28L|TAC1_uc003uos.3_Silent_p.L28L	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	28					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	ATGATGATCTGAATTACTGGT	0.532													0	0	0	0.00333	0	25	71										A	97362008	G	A	97362008	2	1	46	1	0	0	0	0	0	0	0	1	15495	1277	45	1		1	TAC1	7	97362008	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2821503	97362008	61776655	718	12415										
TRRAP	8295	broad.mit.edu	37	chr7	98528285	98528285	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcccctgttttcttacatCgtggagcgcctgtgtgcatg	11	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:98528285C>T	uc003upp.2	+	25	3632	c.3423C>T	c.(3421-3423)ATC>ATT	p.I1141I	TRRAP_uc011kis.1_Silent_p.I1141I|TRRAP_uc003upr.2_Silent_p.I833I	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1141					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTTCTTACATCGTGGAGCGCC	0.433													0	0	0	0.01441	0	104	130										T	98528285	C	T	98528285	2	4	46	1	0	0	0	0	0	0	0	1	16598	874	31	1		1	TRRAP	7	98528285	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1166277	98528285	60610378	719	12416										
TRRAP	8295	broad.mit.edu	37	chr7	98581886	98581886	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcggattcatactattccaActgttcctatcgtggattgc	8	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:98581886A>G	uc003upp.2	+	60	9414	c.9205A>G	c.(9205-9207)ACT>GCT	p.T3069A	TRRAP_uc011kis.1_Missense_Mutation_p.T3040A|TRRAP_uc003upr.2_Missense_Mutation_p.T2757A	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3069	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TACTATTCCAACTGTTCCTAT	0.473													0	0	0	0.00874	0	38	126										G	98581886	A	G	98581886	3	3	46	1	0	0	0	0	1	0	0	0	16598	43	2	5	9348	5	TRRAP	7	98581886	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	53601	98581886	60556777	720	12417										
PTCD1	26024	broad.mit.edu	37	chr7	99021515	99021515	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgatgagataggtgtagttCagcttcctgatggccgcgtt	13	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99021515C>A	uc003uqh.2	-	7	1934	c.1803G>T	c.(1801-1803)CTG>CTT	p.L601L	PTCD1_uc011kiw.1_Silent_p.L650L	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	601	PPR 9.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AGGTGTAGTTCAGCTTCCTGA	0.527													1	0	7.92952e-12	0.003954	8.28857e-12	26	71										A	99021515	C	A	99021515	2	1	46	1	0	0	0	0	0	0	0	1	12727	813	29	3		3	PTCD1	7	99021515	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	439629	99021515	60117148	721	12418										
CPSF4	10898	broad.mit.edu	37	chr7	99048377	99048377	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcatctgtgtgaattacctCgtgggattctgcccggaggg	14	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99048377C>T	uc003uqj.2	+	5	599	c.456C>T	c.(454-456)CTC>CTT	p.L152L	PTCD1_uc011kiw.1_Intron|CPSF4_uc003uqi.2_Silent_p.L152L|CPSF4_uc003uqk.2_Silent_p.L152L|CPSF4_uc011kix.1_Silent_p.L99L	NM_006693	NP_006684	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4,	152	C3H1-type 5.				modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGAATTACCTCGTGGGATTCT	0.617													0	0	0	0.012319	0	20	67										T	99048377	C	T	99048377	2	4	46	1	0	0	0	0	0	0	0	1	3828	871	31	1		1	CPSF4	7	99048377	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	26862	99048377	60090286	722	12419										
ZNF655	79027	broad.mit.edu	37	chr7	99170633	99170633	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaaaattcacaccagagccaAatcttacaaatgtagcagtt	6	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99170633A>C	uc003urh.2	+	3	1295	c.902A>C	c.(901-903)AAA>ACA	p.K301T	ZNF655_uc010lga.2_Missense_Mutation_p.K336T|ZNF655_uc010lgc.2_Missense_Mutation_p.K336T|ZNF655_uc003urj.2_Missense_Mutation_p.K301T|ZNF655_uc003urk.2_Missense_Mutation_p.K138T|ZNF655_uc010lgd.2_Missense_Mutation_p.K138T	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	301					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					ACCAGAGCCAAATCTTACAAA	0.393													0	0	0	0.014323	0	22	79										C	99170633	A	C	99170633	3	2	46	1	0	0	0	0	1	0	0	0	18065	14	1	5	1439	5	ZNF655	7	99170633	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	122256	99170633	59968030	723	12420										
CYP3A7	1551	broad.mit.edu	37	chr7	99305506	99305506	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcaagtttcatgttcacgaGagcaaacctcatgccaatgc	8	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99305506G>C	uc003uru.2	-	12	1450	c.1345C>G	c.(1345-1347)CTC>GTC	p.L449V	ZNF498_uc003urn.2_RNA|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	449					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					ATGTTCACGAGAGCAAACCTC	0.403													0	0	0	0.01441	0	112	110										C	99305506	G	C	99305506	3	2	46	1	0	0	0	0	1	0	0	0	4181	942	33	1	174	1	CYP3A7	7	99305506	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	134873	99305506	59833157	724	12421										
C7orf47	221908	broad.mit.edu	37	chr7	100033913	100033913	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggctcggagttgcgggacttGgggctccgggggtggccccg	21	11	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100033913G>C	uc003uuy.1	-	1	182	c.85C>G	c.(85-87)CAA>GAA	p.Q29E	C7orf47_uc003uux.1_5'UTR	NM_145030	NP_659467	Q8TAP8	CG047_HUMAN	hypothetical protein LOC221908	29	Pro-rich.									ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGCGGGACTTGGGGCTCCGGG	0.677													0	0	0	0.001168	0	5	11										C	100033913	G	C	100033913	3	2	46	1	0	0	0	0	1	0	0	0	2397	1357	47	4	692	4	C7orf47	7	100033913	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	728407	100033913	59104750	725	12422										
LRCH4	4034	broad.mit.edu	37	chr7	100180050	100180050	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccagctggcacgccgcctCgggcacctcgggaaaccggt	13	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100180050C>T	uc003uvj.2	-	2	306	c.253G>A	c.(253-255)GAG>AAG	p.E85K	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	85	LRR 2.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACGCCGCCTCGGGCACCTCG	0.647													0	0	0	0.004007	0	16	23										T	100180050	C	T	100180050	3	4	46	1	0	0	0	0	1	0	0	0	8935	893	31	1	1866	1	LRCH4	7	100180050	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	146137	100180050	58958613	726	12423										
PCOLCE	5118	broad.mit.edu	37	chr7	100201832	100201832	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtacagcgggcgggccacctCgggcactggtgagaactccc	15	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100201832C>T	uc003uvo.2	+	3	653	c.455C>T	c.(454-456)TCG>TTG	p.S152L	uc011kjy.1_5'Flank|PCOLCE_uc011kkb.1_Missense_Mutation_p.S152L|PCOLCE_uc010lhb.1_Intron|PCOLCE_uc003uvp.1_5'Flank	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	152					multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CGGGCCACCTCGGGCACTGGT	0.522													0	0	0	0.000602	0	4	33										T	100201832	C	T	100201832	3	4	46	1	0	0	0	0	1	0	0	0	11594	893	31	1	465	1	PCOLCE	7	100201832	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	21782	100201832	58936831	727	12424										
ZAN	7455	broad.mit.edu	37	chr7	100391797	100391797	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcggtgcacctgtgccagctCacggatcctgctgtgtgagc	14	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100391797C>T	uc003uwj.2	+	45	8207	c.8042C>T	c.(8041-8043)TCA>TTA	p.S2681L	ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.S629L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2681	VWFC 5.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGTGCCAGCTCACGGATCCTG	0.617													0	0	0	0.01441	0	49	34										T	100391797	C	T	100391797	3	4	46	1	0	0	0	0	1	0	0	0	17510	838	29	1	8276	1	ZAN	7	100391797	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	189965	100391797	58746866	728	12425										
SRRT	51593	broad.mit.edu	37	chr7	100478981	100478981	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggaatcggcgagagcgcttCtcgccacctcgccacgaact	11	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100478981C>T	uc003uwy.2	+	4	466	c.198C>T	c.(196-198)TTC>TTT	p.F66F	SRRT_uc010lhl.1_Silent_p.F66F|SRRT_uc003uxa.2_Silent_p.F66F|SRRT_uc003uwz.2_Silent_p.F66F	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	66	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GAGAGCGCTTCTCGCCACCTC	0.597													0	0	0	0.004656	0	23	34										T	100478981	C	T	100478981	2	4	46	1	0	0	0	0	0	0	0	1	15171	912	32	1		1	SRRT	7	100478981	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	87184	100478981	58659682	729	12426										
SERPINE1	5054	broad.mit.edu	37	chr7	100773891	100773891	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggacttttcagaggtggagaGagccagattcatcatcaatg	12	7	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100773891G>A	uc003uxt.2	+	3	609	c.461G>A	c.(460-462)AGA>AAA	p.R154K	SERPINE1_uc011kkj.1_Missense_Mutation_p.R139K|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	154					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GAGGTGGAGAGAGCCAGATTC	0.527													0	0	0	0.01441	0	120	124										A	100773891	G	A	100773891	3	1	46	1	0	0	0	0	1	0	0	0	14111	942	33	1	467	1	SERPINE1	7	100773891	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	294910	100773891	58364772	730	12427										
VGF	7425	broad.mit.edu	37	chr7	100806760	100806760	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtttggtggacagctcaatGaggctgtcgatcgtctgcgg	15	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100806760G>A	uc003uxx.3	-	2	1583	c.1365C>T	c.(1363-1365)CTC>CTT	p.L455L		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	455					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					ACAGCTCAATGAGGCTGTCGA	0.463													0	0	0	0.000602	0	5	10										A	100806760	G	A	100806760	2	1	46	1	0	0	0	0	0	0	0	1	17154	1277	45	1		1	VGF	7	100806760	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	32869	100806760	58331903	731	12428										
MLL5	55904	broad.mit.edu	37	chr7	104752302	104752302	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggatctgtaattcctgctCaagcacacgggaaaatattc	8	10	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:104752302C>G	uc003vcm.2	+	27	4633	c.4099C>G	c.(4099-4101)CAA>GAA	p.Q1367E	MLL5_uc010ljc.2_Missense_Mutation_p.Q1367E|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.Q101E	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1367					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AATTCCTGCTCAAGCACACGG	0.408													0	0	0	0.00245	0	13	60										G	104752302	C	G	104752302	3	3	46	1	0	0	0	0	1	0	0	0	9624	827	29	1	4197	1	MLL5	7	104752302	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3945542	104752302	54386361	732	12429										
SRPK2	6733	broad.mit.edu	37	chr7	104782887	104782887	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacatcatcttcatctttttCaatgttttctttctcagcat	2	10	7	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:104782887C>T	uc003vct.2	-	10	1265	c.1078G>A	c.(1078-1080)GAA>AAA	p.E360K	SRPK2_uc003vcu.2_Missense_Mutation_p.E360K|SRPK2_uc003vcv.2_Missense_Mutation_p.E371K|SRPK2_uc003vcw.1_Missense_Mutation_p.E360K	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	360	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCATCTTTTTCAATGTTTTCT	0.393													0	0	0	0.012213	0	33	137										T	104782887	C	T	104782887	3	4	46	1	0	0	0	0	1	0	0	0	15159	835	29	1	1012	1	SRPK2	7	104782887	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	30585	104782887	54355776	733	12430										
WNT2	7472	broad.mit.edu	37	chr7	116962989	116962989	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagttgacctcgggggtgaGccaggtcaagagcagaggga	18	7	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:116962989G>A	uc003viz.2	-	1	355	c.55C>T	c.(55-57)CTC>TTC	p.L19F	WNT2_uc003vja.2_5'UTR	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	19					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TCGGGGGTGAGCCAGGTCAAG	0.607													0	0	0	0.001168	0	5	25										A	116962989	G	A	116962989	3	1	46	1	0	0	0	0	1	0	0	0	17383	971	34	2	1047	2	WNT2	7	116962989	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	12180102	116962989	42175674	734	12431										
C7orf58	79974	broad.mit.edu	37	chr7	120767150	120767150	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgttctttcaaaggtacacGagcatttaaattttcaagat	6	6	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:120767150G>A	uc003vjq.3	+	10	1588	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K	C7orf58_uc003vjr.1_Missense_Mutation_p.E381K|C7orf58_uc003vjs.3_Missense_Mutation_p.E381K|C7orf58_uc003vjt.3_Missense_Mutation_p.E161K|C7orf58_uc010lkk.1_Missense_Mutation_p.E161K	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	381						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AAAGGTACACGAGCATTTAAA	0.289													0	0	0	0.00245	0	14	61										A	120767150	G	A	120767150	3	1	46	1	0	0	0	0	1	0	0	0	2405	1059	37	1	1175	1	C7orf58	7	120767150	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3804161	120767150	38371513	735	12432										
RNF133	168433	broad.mit.edu	37	chr7	122337916	122337916	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgagaagtagggttctcctCcacatggattactttatctg	9	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:122337916C>T	uc003vkj.1	-	1	1293	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	353						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						GGGTTCTCCTCCACATGGATT	0.408													0	0	0	0.01441	0	61	135										T	122337916	C	T	122337916	3	4	46	1	0	0	0	0	1	0	0	0	13439	864	30	1	77	1	RNF133	7	122337916	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1570766	122337916	36800747	736	12433										
POT1	25913	broad.mit.edu	37	chr7	124482960	124482960	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcggtattgttgaggagctTtttgtttcaaaatggcacat	11	5	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:124482960T>A	uc003vlm.2	-	13	1665	c.1064A>T	c.(1063-1065)AAA>ATA	p.K355I	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.K224I|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	355					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						TTGAGGAGCTTTTTGTTTCAA	0.353													0	0	0	0.006122	0	19	72										A	124482960	T	A	124482960	3	1	46	1	0	0	0	0	1	0	0	0	12260	1841	64	5	868	5	POT1	7	124482960	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2145044	124482960	34655703	737	12434										
GCC1	79571	broad.mit.edu	37	chr7	127224211	127224211	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atatggataattacctttctCatttcctgctgtaactgagc	6	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:127224211C>T	uc003vma.2	-	1	1444	c.1026G>A	c.(1024-1026)ATG>ATA	p.M342I		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	342	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TTACCTTTCTCATTTCCTGCT	0.443													0	0	0	0.007413	0	15	45										T	127224211	C	T	127224211	3	4	46	1	0	0	0	0	1	0	0	0	6285	826	29	1	1309	1	GCC1	7	127224211	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2741251	127224211	31914452	738	12435										
FAM71F2	346653	broad.mit.edu	37	chr7	128317717	128317717	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagatctactatctgaagctCcacgaaaaacacccagagat	6	11	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:128317717C>A	uc003vnk.3	+	3	571	c.465C>A	c.(463-465)CTC>CTA	p.L155L	FAM71F2_uc010llm.1_Silent_p.L146L|FAM71F2_uc003vnl.2_RNA|FAM71F2_uc010lln.1_RNA	NM_001012454	NP_001012457	Q6NXP2	F71F2_HUMAN	hypothetical protein LOC346653 isoform a	155											0						ATCTGAAGCTCCACGAAAAAC	0.502													1	0	1.15919e-05	0.008871	1.18429e-05	17	39										A	128317717	C	A	128317717	2	1	46	1	0	0	0	0	0	0	0	1	5613	842	30	3		3	FAM71F2	7	128317717	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1093506	128317717	30820946	739	12436										
EXOC4	60412	broad.mit.edu	37	chr7	132990735	132990735	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaaccttcacttggttctCatagatgaactacaccggca	7	11	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:132990735C>T	uc003vrk.2	+	4	611	c.576C>T	c.(574-576)CTC>CTT	p.L192L	EXOC4_uc011kpo.1_Silent_p.L91L|EXOC4_uc003vri.2_Silent_p.L192L|EXOC4_uc003vrj.2_Silent_p.L192L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	192					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				ACTTGGTTCTCATAGATGAAC	0.488													0	0	0	0.003163	0	15	56										T	132990735	C	T	132990735	2	4	46	1	0	0	0	0	0	0	0	1	5306	813	29	1		1	EXOC4	7	132990735	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4673018	132990735	26147928	740	12437										
AKR1B1	231	broad.mit.edu	37	chr7	134135636	134135636	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctttcaccaggcccttctCatggtacgtgcaccacagct	7	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:134135636C>T	uc003vrp.1	-	3	327	c.253G>A	c.(253-255)GAG>AAG	p.E85K	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	85					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	AGGCCCTTCTCATGGTACGTG	0.562													0	0	0	0.00308	0	8	28										T	134135636	C	T	134135636	3	4	46	1	0	0	0	0	1	0	0	0	466	835	29	1	729	1	AKR1B1	7	134135636	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1144901	134135636	25003027	741	12438										
WDR91	29062	broad.mit.edu	37	chr7	134873230	134873230	+	Silent	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acggtgttctcatcatagctGaactccacagagtagacctc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:134873230G>A	uc003vsp.2	-	13	1898	c.1836C>T	c.(1834-1836)TTC>TTT	p.F612F	WDR91_uc010lmq.2_Silent_p.F201F|WDR91_uc010lmr.2_Intron	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	612	WD 5.									breast(2)|ovary(1)|skin(1)	4						CATCATAGCTGAACTCCACAG	0.443													0	0	0	0.003755	0	33	104										A	134873230	G	A	134873230	2	1	46	1	0	0	0	0	0	0	0	1	17335	1281	45	1		1	WDR91	7	134873230	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	737594	134873230	24265433	742	12439	58	2								
WDR91	29062	broad.mit.edu	37	chr7	134873240	134873240	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcatagctgaactccacaGagtagacctccccgtagtgg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:134873240G>A	uc003vsp.2	-	13	1888	c.1826C>T	c.(1825-1827)TCT>TTT	p.S609F	WDR91_uc010lmq.2_Missense_Mutation_p.S198F|WDR91_uc010lmr.2_Intron	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	609	WD 5.									breast(2)|ovary(1)|skin(1)	4						GAACTCCACAGAGTAGACCTC	0.483													0	0	0	0.004878	0	34	110										A	134873240	G	A	134873240	3	1	46	1	0	0	0	0	1	0	0	0	17335	942	33	1	429	1	WDR91	7	134873240	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10	134873240	24265423	743	12440	58	2								
CNOT4	4850	broad.mit.edu	37	chr7	135123034	135123034	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccaagggctccatgcaaaGagggcactccacagggtctt	11	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:135123034G>C	uc003vsv.1	-	2	353	c.46C>G	c.(46-48)CTT>GTT	p.L16V	CNOT4_uc003vss.2_Missense_Mutation_p.L16V|CNOT4_uc011kpz.1_Missense_Mutation_p.L16V|CNOT4_uc003vst.2_Missense_Mutation_p.L16V|CNOT4_uc003vsu.1_Missense_Mutation_p.L16V|CNOT4_uc011kpy.1_Missense_Mutation_p.L16V	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	16	RING-type; degenerate.			L->A,E: Abolishes interaction with E2 ubiquitin ligases.	nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TCCATGCAAAGAGGGCACTCC	0.443													0	0	0	0.00278	0	24	22										C	135123034	G	C	135123034	3	2	46	1	0	0	0	0	1	0	0	0	3621	942	33	1	2018	1	CNOT4	7	135123034	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	249794	135123034	24015629	744	12441										
NUP205	23165	broad.mit.edu	37	chr7	135329649	135329649	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgtttcttctagttgtgtCagtctgtgatgcctgctggt	11	7	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:135329649C>T	uc003vsw.2	+	40	5597	c.5566C>T	c.(5566-5568)CAG>TAG	p.Q1856*	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1856					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CTAGTTGTGTCAGTCTGTGAT	0.383													0	0	0	0.00632	0	29	99										T	135329649	C	T	135329649	4	4	46	1	0	0	0	0	0	1	0	0	10759	827	29	1	5724	1	NUP205	7	135329649	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	206615	135329649	23809014	745	12442										
CHRM2	1129	broad.mit.edu	37	chr7	136700170	136700170	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttttttccaatgctgctgtCacctttggtacggctattgc	8	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:136700170C>G	uc003vtf.1	+	4	1181	c.558C>G	c.(556-558)GTC>GTG	p.V186V	CHRM2_uc003vtg.1_Silent_p.V186V|CHRM2_uc003vtj.1_Silent_p.V186V|CHRM2_uc003vtk.1_Silent_p.V186V|CHRM2_uc003vtl.1_Silent_p.V186V|CHRM2_uc003vtm.1_Silent_p.V186V|CHRM2_uc003vti.1_Silent_p.V186V|CHRM2_uc003vto.1_Silent_p.V186V|CHRM2_uc003vtn.1_Silent_p.V186V|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	186	Helical; Name=5; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ATGCTGCTGTCACCTTTGGTA	0.488													0	0	0	0.01441	0	57	60										G	136700170	C	G	136700170	2	3	46	1	0	0	0	0	0	0	0	1	3377	813	29	1		1	CHRM2	7	136700170	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1370521	136700170	22438493	746	12443										
DGKI	9162	broad.mit.edu	37	chr7	137262020	137262020	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacttctctgtaggaagtcaGaaaaagctgcctataccaca	7	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:137262020G>C	uc003vtt.2	-	17	1710	c.1709C>G	c.(1708-1710)TCT>TGT	p.S570C	DGKI_uc003vtu.2_Missense_Mutation_p.S270C	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	570					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						TAGGAAGTCAGAAAAAGCTGC	0.328													0	0	0	0.004672	0	3	26										C	137262020	G	C	137262020	3	2	46	1	0	0	0	0	1	0	0	0	4471	942	33	1	1560	1	DGKI	7	137262020	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	561850	137262020	21876643	747	12444										
LUC7L2	51631	broad.mit.edu	37	chr7	139083368	139083368	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggatcttggagaatgtctGaaagtccatgacctggcttt	11	7	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:139083368G>A	uc003vux.2	+	3	554	c.180G>A	c.(178-180)CTG>CTA	p.L60L	LUC7L2_uc011kqs.1_Silent_p.L57L|LUC7L2_uc011kqt.1_Silent_p.L126L|LUC7L2_uc003vuy.2_Silent_p.L59L|LUC7L2_uc003vuz.1_Silent_p.L7L|LUC7L2_uc003vva.2_Silent_p.L7L	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	60							enzyme binding|metal ion binding				0	Melanoma(164;0.242)					GAGAATGTCTGAAAGTCCATG	0.308													0	0	0	0.01441	0	49	52										A	139083368	G	A	139083368	2	1	46	1	0	0	0	0	0	0	0	1	9083	1277	45	1		1	LUC7L2	7	139083368	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1821348	139083368	20055295	748	12445										
JHDM1D	80853	broad.mit.edu	37	chr7	139838913	139838913	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctagtacttactcaaggagGaaccatgtaaaactgcacag	8	9	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:139838913G>T	uc003vvm.2	-	2	276	c.272C>A	c.(271-273)TCC>TAC	p.S91Y		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	91					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					ACTCAAGGAGGAACCATGTAA	0.358													1	0	6.03168e-27	0.004878	6.39099e-27	38	98										T	139838913	G	T	139838913	3	4	46	1	0	0	0	0	1	0	0	0	7948	1174	41	3	2629	3	JHDM1D	7	139838913	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	755545	139838913	19299750	749	12446										
RAB19	401409	broad.mit.edu	37	chr7	140125723	140125723	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaagcggcacgtcctgttcGaggatgcctgcacactggct	12	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:140125723G>C	uc010lni.2	+	4	625	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	RAB19_uc011krc.1_Missense_Mutation_p.E143Q	NM_001008749	NP_001008749	A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	143					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0	Melanoma(164;0.0142)					CGTCCTGTTCGAGGATGCCTG	0.468													0	0	0	0.010771	0	44	132										C	140125723	G	C	140125723	3	2	46	1	0	0	0	0	1	0	0	0	12904	1059	37	1	437	1	RAB19	7	140125723	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	286810	140125723	19012940	750	12447										
DENND2A	27147	broad.mit.edu	37	chr7	140301337	140301337	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttttctctttcctgaagccGatgccaggcttcccatcttt	6	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:140301337G>A	uc010lnj.2	-	1	1006	c.861C>T	c.(859-861)ATC>ATT	p.I287I	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.I287I|DENND2A_uc003vvw.2_Silent_p.I287I|DENND2A_uc003vvx.2_Silent_p.I287I	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	287										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TCCTGAAGCCGATGCCAGGCT	0.378													0	0	0	0.01441	0	47	105										A	140301337	G	A	140301337	2	1	46	1	0	0	0	0	0	0	0	1	4429	1048	37	1		1	DENND2A	7	140301337	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	175614	140301337	18837326	751	12448										
EPHB6	2051	broad.mit.edu	37	chr7	142564247	142564247	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcactctagtgccctctgctGtccctgtggtgcaccaggtg	12	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:142564247G>A	uc011kst.1	+	10	2258	c.1471G>A	c.(1471-1473)GTC>ATC	p.V491I	EPHB6_uc011ksu.1_Missense_Mutation_p.V491I|EPHB6_uc003wbs.2_Missense_Mutation_p.V199I|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.V199I|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	491	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GCCCTCTGCTGTCCCTGTGGT	0.607													0	0	0	0.010729	0	11	43										A	142564247	G	A	142564247	3	1	46	1	0	0	0	0	1	0	0	0	5178	1377	48	2	1493	2	EPHB6	7	142564247	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2262910	142564247	16574416	752	12449										
OR2A5	393046	broad.mit.edu	37	chr7	143747957	143747957	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttgggcatgtggttcccttCtggccctggtccatgtggtt	13	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:143747957C>T	uc011ktw.1	+	1	463	c.463C>T	c.(463-465)CTG>TTG	p.L155L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGGTTCCCTTCTGGCCCTGGT	0.532													0	0	0	0.01441	0	62	166										T	143747957	C	T	143747957	2	4	46	1	0	0	0	0	0	0	0	1	10981	912	32	1		1	OR2A5	7	143747957	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1183710	143747957	15390706	753	12450										
NOBOX	135935	broad.mit.edu	37	chr7	144101707	144101707	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgatgaagaaggagctgaaaGagccacagactccgtagatc	12	8	0	7			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:144101707G>A	uc011kue.1	-	2	152	c.152C>T	c.(151-153)TCT>TTT	p.S51F		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	51					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GGAGCTGAAAGAGCCACAGAC	0.463													0	0	0	0.007413	0	18	71										A	144101707	G	A	144101707	3	1	46	1	0	0	0	0	1	0	0	0	10512	957	33	1		1	NOBOX	7	144101707	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	353750	144101707	15036956	754	12451										
ZNF786	136051	broad.mit.edu	37	chr7	148771522	148771522	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggatcaaaatgcatatcaAcagaggagcaaattatgttt	8	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:148771522A>G	uc003wfh.2	-	3	391	c.254T>C	c.(253-255)GTT>GCT	p.V85A	ZNF786_uc011kuk.1_Missense_Mutation_p.V48A|ZNF786_uc003wfi.2_5'UTR	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ATGCATATCAACAGAGGAGCA	0.428													0	0	0	0.006214	0	10	40										G	148771522	A	G	148771522	3	3	46	1	0	0	0	0	1	0	0	0	18155	43	2	5	2102	5	ZNF786	7	148771522	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	4669815	148771522	10367141	755	12452										
AGAP3	116988	broad.mit.edu	37	chr7	150814758	150814758	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgcagtggtgtttgtgttCagcctggaggatgaaatcag	15	5	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:150814758C>T	uc003wjg.1	+	5	603	c.600C>T	c.(598-600)TTC>TTT	p.F200F	AGAP3_uc003wje.1_5'UTR|AGAP3_uc003wjf.1_Silent_p.F200F|AGAP3_uc010lpy.1_Silent_p.F200F|AGAP3_uc003wjh.1_Silent_p.F380F	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	164	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TGTTTGTGTTCAGCCTGGAGG	0.552													0	0	0	0.00623	0	40	129										T	150814758	C	T	150814758	2	4	46	1	0	0	0	0	0	0	0	1	369	825	29	1		1	AGAP3	7	150814758	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2043236	150814758	8323905	756	12453										
GALNT11	63917	broad.mit.edu	37	chr7	151818704	151818704	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcccctgggtcagaagggctCtgtcgccatggcgatctgcg	14	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:151818704C>T	uc010lqg.1	+	12	1999	c.1769C>T	c.(1768-1770)TCT>TTT	p.S590F	GALNT11_uc011kvm.1_Missense_Mutation_p.S509F|GALNT11_uc003wku.2_Missense_Mutation_p.S590F	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	590	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CAGAAGGGCTCTGTCGCCATG	0.517													0	0	0	0.00499	0	18	41										T	151818704	C	T	151818704	3	4	46	1	0	0	0	0	1	0	0	0	6209	913	32	1	1811	1	GALNT11	7	151818704	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1003946	151818704	7319959	757	12454										
RNF32	140545	broad.mit.edu	37	chr7	156437437	156437437	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgttcttgatcccaaaccgcCgccgttgactttgggtaagc	10	12	1	2	rs138495614		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:156437437C>G	uc003wmo.2	+	3	442	c.260C>G	c.(259-261)CCG>CGG	p.P87R	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.P87R|RNF32_uc003wmp.2_Missense_Mutation_p.P87R|RNF32_uc003wmq.2_Missense_Mutation_p.P87R|RNF32_uc003wmr.2_Missense_Mutation_p.P87R|RNF32_uc003wms.2_Missense_Mutation_p.P87R|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.P87R	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	87						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CCCAAACCGCCGCCGTTGACT	0.348													0	0	0	0.003163	0	14	51										G	156437437	C	G	156437437	3	3	46	1	0	0	0	0	1	0	0	0	13488	652	23	4	266	4	RNF32	7	156437437	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4618733	156437437	2701226	758	12455										
NOM1	64434	broad.mit.edu	37	chr7	156743173	156743173	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgccggacagacactccccGaaagtgacttagagagtgac	11	11	0	4	rs151324588	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:156743173G>A	uc003wmy.2	+	1	757	c.742G>A	c.(742-744)GAA>AAA	p.E248K		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	248	Glu-rich.|Necessary for nucleolar localization and for targeting PPP1CA to the nucleolus.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GACACTCCCCGAAAGTGACTT	0.338													0	0	0	0.003163	0	15	58										A	156743173	G	A	156743173	3	1	46	1	0	0	0	0	1	0	0	0	10530	1059	37	1	744	1	NOM1	7	156743173	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	305736	156743173	2395490	759	12456										
NOM1	64434	broad.mit.edu	37	chr7	156754887	156754887	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgttggccctgaagaacaatGacatgcgcaaaattccaggc	10	10	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:156754887G>A	uc003wmy.2	+	5	1690	c.1675G>A	c.(1675-1677)GAC>AAC	p.D559N	NOM1_uc010lqp.1_Missense_Mutation_p.D8N	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	559	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GAAGAACAATGACATGCGCAA	0.438													0	0	0	0.01441	0	86	102										A	156754887	G	A	156754887	3	1	46	1	0	0	0	0	1	0	0	0	10530	1290	45	1	1693	1	NOM1	7	156754887	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	11714	156754887	2383776	760	12457										
DEFA5	1670	broad.mit.edu	37	chr8	6914118	6914118	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctggttgtcttccccagaCtgcttctgggttgtagcctc	10	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:6914118C>T	uc003wra.1	-	1	142	c.102G>A	c.(100-102)CAG>CAA	p.Q34Q		NM_021010	NP_066290	Q01523	DEF5_HUMAN	defensin, alpha 5 preproprotein	34					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CTTCCCCAGACTGCTTCTGGG	0.537													0	0	0	0.012213	0	33	25										T	6914118	C	T	6914118	2	4	46	1	0	0	0	0	0	0	0	1	4392	564	20	2		2	DEFA5	8	6914118	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		6914118	139449904	761	12458										
RP1L1	94137	broad.mit.edu	37	chr8	10465561	10465561	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccgtctgactctggctggGcctcctcttctgcctcttgc	9	17	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:10465561G>A	uc003wtc.2	-	4	6276	c.6047C>T	c.(6046-6048)GCC>GTC	p.A2016V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2016					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCTGGCTGGGCCTCCTCTTC	0.607													0	0	0	0.004878	0	37	57										A	10465561	G	A	10465561	3	1	46	1	0	0	0	0	1	0	0	0	13533	1203	42	2	1159	2	RP1L1	8	10465561	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3551443	10465561	135898461	762	12459										
SOX7	83595	broad.mit.edu	37	chr8	10583400	10583400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcggagtctgggtggccagGagtgttcaaatactggtcga	17	7	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:10583400G>A	uc003wtf.2	-	2	1094	c.1015C>T	c.(1015-1017)CCT>TCT	p.P339S	SOX7_uc011kwz.1_Missense_Mutation_p.P391S	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	339	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGGTGGCCAGGAGTGTTCAAA	0.612													0	0	0	0.013537	0	12	13										A	10583400	G	A	10583400	3	1	46	1	0	0	0	0	1	0	0	0	14956	1174	41	1	155	1	SOX7	8	10583400	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	117839	10583400	135780622	763	12460										
MTMR7	9108	broad.mit.edu	37	chr8	17161949	17161949	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccctgagtctggctgtgatCagctctaaacagaggattca	10	10	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:17161949C>T	uc003wxm.2	-	12	1671	c.1432G>A	c.(1432-1434)GAT>AAT	p.D478N	MTMR7_uc003wxn.2_Missense_Mutation_p.D257N|MTMR7_uc011kya.1_Missense_Mutation_p.D112N|MTMR7_uc011kyb.1_Missense_Mutation_p.D69N	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	478	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		TGGCTGTGATCAGCTCTAAAC	0.418													0	0	0	0.009535	0	30	28										T	17161949	C	T	17161949	3	4	46	1	0	0	0	0	1	0	0	0	9948	826	29	1	562	1	MTMR7	8	17161949	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6578549	17161949	129202073	764	12461										
MTMR7	9108	broad.mit.edu	37	chr8	17198941	17198941	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctaatggcctggagcatCtgctcgtcctctaggcaccg	10	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:17198941C>A	uc003wxm.2	-	6	902	c.663G>T	c.(661-663)CAG>CAT	p.Q221H	MTMR7_uc003wxn.2_5'UTR	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	221	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CCTGGAGCATCTGCTCGTCCT	0.572													1	0	0.00185496	0.001855	0.00188537	14	13										A	17198941	C	A	17198941	3	1	46	1	0	0	0	0	1	0	0	0	9948	912	32	3	1355	3	MTMR7	8	17198941	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	36992	17198941	129165081	765	12462										
FGL1	2267	broad.mit.edu	37	chr8	17722196	17722196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaggtgtaccagacaatccCattgtctgttttagccgtgt	9	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:17722196C>T	uc003wxx.2	-	9	1168	c.844G>A	c.(844-846)GGG>AGG	p.G282R	FGL1_uc003wxy.2_Missense_Mutation_p.G282R|FGL1_uc003wxz.2_Missense_Mutation_p.G281R|FGL1_uc003wya.2_Missense_Mutation_p.G282R|FGL1_uc003wyb.2_Missense_Mutation_p.G282R|FGL1_uc003wyc.2_Missense_Mutation_p.G282R|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Missense_Mutation_p.G332R|FGL1_uc003wyf.2_Missense_Mutation_p.G252R	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	282	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAGACAATCCCATTGTCTGTT	0.403													0	0	0	0.010729	0	11	10										T	17722196	C	T	17722196	3	4	46	1	0	0	0	0	1	0	0	0	5872	594	21	2	98	2	FGL1	8	17722196	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	523255	17722196	128641826	766	12463										
PSD3	23362	broad.mit.edu	37	chr8	18725265	18725265	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccattggtgacgccactaGaatagcccatcacgatgcca	9	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:18725265G>C	uc003wza.2	-	4	1656	c.1553C>G	c.(1552-1554)TCT>TGT	p.S518C		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	518					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GACGCCACTAGAATAGCCCAT	0.527													0	0	0	0.008871	0	21	30										C	18725265	G	C	18725265	3	2	46	1	0	0	0	0	1	0	0	0	12648	942	33	1	1678	1	PSD3	8	18725265	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1003069	18725265	127638757	767	12464										
RHOBTB2	23221	broad.mit.edu	37	chr8	22864615	22864615	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcccacaagatctacctctCcacctcttcctccaagttct	3	18	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:22864615C>G	uc003xcq.2	+	5	1394	c.857C>G	c.(856-858)TCC>TGC	p.S286C	RHOBTB2_uc003xcp.2_Missense_Mutation_p.S308C|RHOBTB2_uc011kzp.1_Missense_Mutation_p.S293C|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	286	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		ATCTACCTCTCCACCTCTTCC	0.657													0	0	0	0.00632	0	26	23										G	22864615	C	G	22864615	3	3	46	1	0	0	0	0	1	0	0	0	13334	855	30	1	956	1	RHOBTB2	8	22864615	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4139350	22864615	123499407	768	12465										
PTK2B	2185	broad.mit.edu	37	chr8	27301724	27301724	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctgtgttctctctccagcCcagccgacctaagtacagac	7	15	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:27301724C>T	uc003xfn.1	+	28	2958	c.2150C>T	c.(2149-2151)CCC>CTC	p.P717L	PTK2B_uc003xfo.1_Missense_Mutation_p.P717L|PTK2B_uc003xfp.1_Missense_Mutation_p.P717L|PTK2B_uc003xfq.1_Missense_Mutation_p.P717L|PTK2B_uc003xfr.1_Missense_Mutation_p.P463L	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	717	Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCTCTCCAGCCCAGCCGACCT	0.537													0	0	0	0.006214	0	8	10										T	27301724	C	T	27301724	3	4	46	1	0	0	0	0	1	0	0	0	12763	637	22	2	2236	2	PTK2B	8	27301724	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4437109	27301724	119062298	769	12466										
EPHX2	2053	broad.mit.edu	37	chr8	27361252	27361252	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagatcaaccgccccatgctCcaggcagctctcatgctcag	8	16	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:27361252C>T	uc003xfu.2	+	3	399	c.318C>T	c.(316-318)CTC>CTT	p.L106L	EPHX2_uc010lut.1_Silent_p.L106L|EPHX2_uc010luu.2_Silent_p.L106L|EPHX2_uc010luv.2_Silent_p.L40L|EPHX2_uc003xfv.2_Silent_p.L53L|EPHX2_uc010luw.2_Silent_p.L40L|EPHX2_uc011lam.1_5'Flank	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	106	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GCCCCATGCTCCAGGCAGCTC	0.507													0	0	0	0.00308	0	7	13										T	27361252	C	T	27361252	2	4	46	1	0	0	0	0	0	0	0	1	5180	842	30	1		1	EPHX2	8	27361252	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	59528	27361252	119002770	770	12467										
PROSC	11212	broad.mit.edu	37	chr8	37632915	37632915	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggagcacataaacgccaaGtgtcctaacctggagtttgt	11	9	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:37632915G>C	uc003xkh.2	+	6	590	c.513G>C	c.(511-513)AAG>AAC	p.K171N		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	171							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	TAAACGCCAAGTGTCCTAACC	0.488													0	0	0	0.01441	0	48	76										C	37632915	G	C	37632915	3	2	46	1	0	0	0	0	1	0	0	0	12559	1020	36	4	535	4	PROSC	8	37632915	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10271663	37632915	108731107	771	12468										
ASH2L	9070	broad.mit.edu	37	chr8	37974186	37974186	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaccttagtaacattggtCctgcttatgacaaccaaaaa	7	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:37974186C>T	uc003xkt.3	+	8	854	c.796C>T	c.(796-798)CCT>TCT	p.P266S	ASH2L_uc011lbk.1_Missense_Mutation_p.P127S|ASH2L_uc003xku.3_Missense_Mutation_p.P172S|ASH2L_uc010lwa.2_Missense_Mutation_p.P172S	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	266					hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				TAACATTGGTCCTGCTTATGA	0.353													0	0	0	0.013726	0	31	43										T	37974186	C	T	37974186	3	4	46	1	0	0	0	0	1	0	0	0	1042	855	30	1	826	1	ASH2L	8	37974186	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	341271	37974186	108389836	772	12469										
WHSC1L1	54904	broad.mit.edu	37	chr8	38148131	38148131	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacagggaagtcccccaagtCatgtttaaggccctggatgt	11	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:38148131C>T	uc003xli.2	-	17	3498	c.2980G>A	c.(2980-2982)GAC>AAC	p.D994N	WHSC1L1_uc011lbm.1_Missense_Mutation_p.D994N|WHSC1L1_uc010lwe.2_Missense_Mutation_p.D945N	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	994	PWWP 2.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TCCCCCAAGTCATGTTTAAGG	0.473			T	NUP98	AML								0	0	0	0.011902	0	47	161										T	38148131	C	T	38148131	3	4	46	1	0	0	0	0	1	0	0	0	17360	826	29	1	1365	1	WHSC1L1	8	38148131	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	173945	38148131	108215891	773	12470										
C8orf86	389649	broad.mit.edu	37	chr8	38369913	38369913	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccagtggttcttaaacttCagcacacaccagaatcacct	7	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:38369913C>T	uc003xlx.1	-	3	689	c.664G>A	c.(664-666)GAA>AAA	p.E222K		NM_207412	NP_997295	Q6ZUL3	CH086_HUMAN	hypothetical protein LOC389649	222											0						tcttaaacttcagcacacacc	0.219													0	0	0	0.006214	0	10	48										T	38369913	C	T	38369913	3	4	46	1	0	0	0	0	1	0	0	0	2442	835	29	1	11	1	C8orf86	8	38369913	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	221782	38369913	107994109	774	12471										
IKBKB	3551	broad.mit.edu	37	chr8	42129721	42129721	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtcatccgatggcacaatCaggtaggccctctgtgcagc	11	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:42129721C>G	uc003xow.1	+	2	280	c.103C>G	c.(103-105)CAG>GAG	p.Q35E	IKBKB_uc003xov.2_Missense_Mutation_p.Q35E|IKBKB_uc010lxh.1_Nonsense_Mutation_p.S24*|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.I7M|IKBKB_uc003xox.1_Translation_Start_Site|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Intron|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.I7M	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	35	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ATGGCACAATCAGGTAGGCCC	0.607													0	0	0	0.003163	0	15	56										G	42129721	C	G	42129721	3	3	46	1	0	0	0	0	1	0	0	0	7611	827	29	1	105	1	IKBKB	8	42129721	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3759808	42129721	104234301	775	12472										
KIAA0146	23514	broad.mit.edu	37	chr8	48508407	48508407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttccaagtggaagttgccctGttattctgaatacttacttt	7	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:48508407G>A	uc003xqd.2	+	9	1141	c.1132G>A	c.(1132-1134)GTT>ATT	p.V378I	KIAA0146_uc011lcz.1_RNA|KIAA0146_uc011lda.1_Missense_Mutation_p.V67I|KIAA0146_uc011ldb.1_Missense_Mutation_p.V378I|KIAA0146_uc010lxs.2_Intron|KIAA0146_uc011ldc.1_Missense_Mutation_p.V308I|KIAA0146_uc011ldd.1_Missense_Mutation_p.V318I|KIAA0146_uc003xqe.2_5'UTR|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.V67I|KIAA0146_uc010lxt.2_Missense_Mutation_p.V67I	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	378											0		Lung NSC(58;0.175)				AAGTTGCCCTGTTATTCTGAA	0.388													0	0	0	0.01441	0	58	53										A	48508407	G	A	48508407	3	1	46	1	0	0	0	0	1	0	0	0	8157	1377	48	2	1166	2	KIAA0146	8	48508407	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6378686	48508407	97855615	776	12473										
ATP6V1H	51606	broad.mit.edu	37	chr8	54742015	54742015	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatacctacctgcagcatatCatccaccatagttagtatat	4	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:54742015C>T	uc003xrl.2	-	4	447	c.295G>A	c.(295-297)GAT>AAT	p.D99N	ATP6V1H_uc003xrk.2_Missense_Mutation_p.D59N|ATP6V1H_uc003xrm.2_Missense_Mutation_p.D99N|ATP6V1H_uc003xrn.2_Missense_Mutation_p.D99N|ATP6V1H_uc011ldv.1_Missense_Mutation_p.D19N|ATP6V1H_uc010lyd.2_Missense_Mutation_p.D35N	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	99					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TGCAGCATATCATCCACCATA	0.318													0	0	0	0.006122	0	17	131										T	54742015	C	T	54742015	3	4	46	1	0	0	0	0	1	0	0	0	1189	826	29	1	1200	1	ATP6V1H	8	54742015	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6233608	54742015	91622007	777	12474										
LYPLA1	10434	broad.mit.edu	37	chr8	54965251	54965251	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgaagtggaagccagcaactGagtgcagtgacacctgccag	13	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:54965251G>A	uc003xry.2	-	7	620	c.426C>T	c.(424-426)CTC>CTT	p.L142L	LYPLA1_uc011ldx.1_Intron|LYPLA1_uc003xrz.2_Silent_p.L121L	NM_006330	NP_006321	O75608	LYPA1_HUMAN	lysophospholipase 1	142					fatty acid metabolic process|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytosol	lysophospholipase activity|palmitoyl-(protein) hydrolase activity			central_nervous_system(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;8.48e-07)|Epithelial(17;9.29e-05)|all cancers(17;0.000689)			GCCAGCAACTGAGTGCAGTGA	0.458													0	0	0	0.006214	0	8	46										A	54965251	G	A	54965251	2	1	46	1	0	0	0	0	0	0	0	1	9116	1277	45	1		1	LYPLA1	8	54965251	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	223236	54965251	91398771	778	12475										
MRPL15	29088	broad.mit.edu	37	chr8	55060079	55060079	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggatcctgccaaatttcctGaagcacgacttgaactcgcc	8	14	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:55060079G>A	uc003xsa.2	+	5	754	c.691G>A	c.(691-693)GAA>AAA	p.E231K		NM_014175	NP_054894	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15 precursor	231					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			CAAATTTCCTGAAGCACGACT	0.438													0	0	0	0.010504	0	20	121										A	55060079	G	A	55060079	3	1	46	1	0	0	0	0	1	0	0	0	9780	1291	45	1	709	1	MRPL15	8	55060079	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	94828	55060079	91303943	779	12476										
XKR4	114786	broad.mit.edu	37	chr8	56015534	56015534	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctctgtcggtgcaagtgttCagcttccgctggtttgtgca							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:56015534C>T	uc003xsf.2	+	1	518	c.486C>T	c.(484-486)TTC>TTT	p.F162F		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	162	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGCAAGTGTTCAGCTTCCGCT	0.652													0	0	0	0.008361	0	30	27										T	56015534	C	T	56015534	2	4	46	1	0	0	0	0	0	0	0	1	17430	825	29	1		1	XKR4	8	56015534	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	955455	56015534	90348488	780	12477	59	2								
XKR4	114786	broad.mit.edu	37	chr8	56015540	56015540	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcggtgcaagtgttcagcttCcgctggtttgtgcacgattt							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:56015540C>T	uc003xsf.2	+	1	524	c.492C>T	c.(490-492)TTC>TTT	p.F164F		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	164	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGTTCAGCTTCCGCTGGTTTG	0.662													0	0	0	0.013537	0	11	40										T	56015540	C	T	56015540	2	4	46	1	0	0	0	0	0	0	0	1	17430	854	30	1		1	XKR4	8	56015540	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6	56015540	90348482	781	12478	59	2								
NSMAF	8439	broad.mit.edu	37	chr8	59555592	59555592	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgattggctctatgctgttCaaagtagtactcctccaagt	9	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:59555592C>A	uc003xtt.2	-	2	314	c.100G>T	c.(100-102)GAA>TAA	p.E34*	NSMAF_uc011lee.1_Nonsense_Mutation_p.E65*|NSMAF_uc003xtu.2_Nonsense_Mutation_p.E34*	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	34					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				CTATGCTGTTCAAAGTAGTAC	0.393													1	0	3.07112e-06	0.010729	3.14652e-06	12	101										A	59555592	C	A	59555592	4	1	46	1	0	0	0	0	0	1	0	0	10674	835	29	3	2773	3	NSMAF	8	59555592	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3540052	59555592	86808430	782	12479										
CYP7B1	9420	broad.mit.edu	37	chr8	65528701	65528701	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgaagctcatcattcatgtCatgatttttttgcaactgac	7	8	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:65528701C>T	uc003xvj.2	-	3	601	c.397G>A	c.(397-399)GAC>AAC	p.D133N		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	133					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TCATTCATGTCATGATTTTTT	0.318													0	0	0	0.008871	0	19	121										T	65528701	C	T	65528701	3	4	46	1	0	0	0	0	1	0	0	0	4197	826	29	1	1139	1	CYP7B1	8	65528701	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5973109	65528701	80835321	783	12480										
PDE7A	5150	broad.mit.edu	37	chr8	66631545	66631545	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttatgataaccgattttcctGaggtaataactgtgagttca	8	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:66631545G>A	uc003xvq.2	-	13	1441	c.1429C>T	c.(1429-1431)CAG>TAG	p.Q477*	MTFR1_uc003xvo.1_Intron|PDE7A_uc003xvp.2_Nonsense_Mutation_p.Q451*	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	477						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CGATTTTCCTGAGGTAATAAC	0.478													0	0	0	0.003163	0	13	87										A	66631545	G	A	66631545	4	1	46	1	0	0	0	0	0	1	0	0	11651	1299	45	1	23	1	PDE7A	8	66631545	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1102844	66631545	79732477	784	12481										
CRH	1392	broad.mit.edu	37	chr8	67089335	67089335	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgagagccgcggggctgtcGagcgagcgccgaggcagcag	20	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67089335G>A	uc003xvy.1	-	2	563	c.378C>T	c.(376-378)CTC>CTT	p.L126L		NM_000756	NP_000747	P06850	CRF_HUMAN	corticotropin releasing hormone precursor	126					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CGGGGCTGTCGAGCGAGCGCC	0.711											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	5										A	67089335	G	A	67089335	2	1	46	1	0	0	0	0	0	0	0	1	3869	1045	37	1		1	CRH	8	67089335	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	457790	67089335	79274687	785	12482										
VCPIP1	80124	broad.mit.edu	37	chr8	67576939	67576939	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgcagaggatggaccatcaCgaatggtactgggagaaaca	14	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67576939C>T	uc003xwn.2	-	1	2514	c.2255G>A	c.(2254-2256)CGT>CAT	p.R752H	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	752					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TGGACCATCACGAATGGTACT	0.448													0	0	0	0.004289	0	37	175										T	67576939	C	T	67576939	3	4	46	1	0	0	0	0	1	0	0	0	17138	536	19	2	1425	2	VCPIP1	8	67576939	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	487604	67576939	78787083	786	12483										
VCPIP1	80124	broad.mit.edu	37	chr8	67577466	67577466	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaccatcccaaaagtgtttGaatccacaaccacatttgcc	4	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67577466G>A	uc003xwn.2	-	1	1987	c.1728C>T	c.(1726-1728)TTC>TTT	p.F576F	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	576					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			AAAAGTGTTTGAATCCACAAC	0.433													0	0	0	0.01441	0	59	261										A	67577466	G	A	67577466	2	1	46	1	0	0	0	0	0	0	0	1	17138	1281	45	1		1	VCPIP1	8	67577466	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	527	67577466	78786556	787	12484										
CSPP1	79848	broad.mit.edu	37	chr8	67976635	67976635	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccggcccggaggtctgtcaTgctgttcccgctccaggtgg	14	15	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67976635T>C	uc003xxi.2	+	1	33	c.2T>C	c.(1-3)ATG>ACG	p.M1T	CSPP1_uc003xxg.1_Missense_Mutation_p.M1T|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.M1T|COPS5_uc003xxd.2_5'Flank|COPS5_uc003xxe.2_5'Flank|COPS5_uc003xxf.2_5'Flank|COPS5_uc010lyv.1_5'Flank	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	1						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGGTCTGTCATGCTGTTCCCG	0.721											OREG0018811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	16										C	67976635	T	C	67976635	3	2	46	1	0	0	0	0	1	0	0	0	3962	1464	51	5	4	5	CSPP1	8	67976635	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	399169	67976635	78387387	788	12485										
CPA6	57094	broad.mit.edu	37	chr8	68421789	68421789	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcttccctcatatgatcttCcaatagagaacatgtgaatg	6	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:68421789C>T	uc003xxq.3	-	5	753	c.497G>A	c.(496-498)GGA>GAA	p.G166E	CPA6_uc003xxr.3_Missense_Mutation_p.G18E|CPA6_uc003xxs.2_Missense_Mutation_p.G166E	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	166					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			ATATGATCTTCCAATAGAGAA	0.299													0	0	0	0.010818	0	29	147										T	68421789	C	T	68421789	3	4	46	1	0	0	0	0	1	0	0	0	3794	855	30	1	844	1	CPA6	8	68421789	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	445154	68421789	77942233	789	12486										
PRDM14	63978	broad.mit.edu	37	chr8	70978524	70978524	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgacctgaaggctcacagGaatatccagaaatttctcat	8	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:70978524G>A	uc003xym.2	-	5	1331	c.1129C>T	c.(1129-1131)CCT>TCT	p.P377S		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			AGGCTCACAGGAATATCCAGA	0.512													0	0	0	0.010504	0	20	112										A	70978524	G	A	70978524	3	1	46	1	0	0	0	0	1	0	0	0	12455	1174	41	1	602	1	PRDM14	8	70978524	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2556735	70978524	75385498	790	12487										
RPL7	6129	broad.mit.edu	37	chr8	74205835	74205835	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaccagaagcaactcactCtacaccctccatggttccag	7	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:74205835C>T	uc003xzg.2	-	1	35	c.13G>A	c.(13-15)GAA>AAA	p.E5K	RPL7_uc003xzh.1_Intron|RDH10_uc003xzi.2_5'Flank	NM_000971	NP_000962	P18124	RL7_HUMAN	ribosomal protein L7	5					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome				0	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			GCAACTCACTCTACACCCTCC	0.502													0	0	0	0.000602	0	5	28										T	74205835	C	T	74205835	3	4	46	1	0	0	0	0	1	0	0	0	13599	927	32	1	757	1	RPL7	8	74205835	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3227311	74205835	72158187	791	12488										
ZNF704	619279	broad.mit.edu	37	chr8	81582772	81582772	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcggatgtgtttctggatacCtgctgcagtgctcagcacct	11	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:81582772C>T	uc003yby.1	-	5	857	c.625G>A	c.(625-627)GGT>AGT	p.G209S		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	209	C2H2-type.					intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TTCTGGATACCTGCTGCAGTG	0.507													0	0	0	0.007291	0	28	161										T	81582772	C	T	81582772	3	4	46	1	0	0	0	0	1	0	0	0	18104	681	24	2	633	2	ZNF704	8	81582772	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7376937	81582772	64781250	792	12489										
SLC10A5	347051	broad.mit.edu	37	chr8	82606862	82606862	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttcacattcttgatttcttCaatgagtctttcttgcctac	4	10	6	2	rs148561963		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:82606862C>T	uc011lfs.1	-	1	346	c.346G>A	c.(346-348)GAA>AAA	p.E116K		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	116	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity				0						TTGATTTCTTCAATGAGTCTT	0.363													0	0	0	0.013114	0	41	183										T	82606862	C	T	82606862	3	4	46	1	0	0	0	0	1	0	0	0	14377	835	29	1	972	1	SLC10A5	8	82606862	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1024090	82606862	63757160	793	12490										
DCAF4L2	138009	broad.mit.edu	37	chr8	88885315	88885315	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggccctcaagtcccacagCttgatagttccagtcatgtc	9	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:88885315C>G	uc003ydz.2	-	1	982	c.885G>C	c.(883-885)AAG>AAC	p.K295N		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	295	WD 1.									ovary(1)	1						AGTCCCACAGCTTGATAGTTC	0.493													0	0	0	0.010729	0	12	81										G	88885315	C	G	88885315	3	3	46	1	0	0	0	0	1	0	0	0	4272	796	28	4	306	4	DCAF4L2	8	88885315	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6278453	88885315	57478707	794	12491										
RUNX1T1	862	broad.mit.edu	37	chr8	93017372	93017372	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttcgcctcttcccgttttCgttcacatcgagaagcagct	8	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:93017372C>T	uc003yfd.2	-	5	796	c.712G>A	c.(712-714)GAA>AAA	p.E238K	RUNX1T1_uc003yfc.1_Missense_Mutation_p.E211K|RUNX1T1_uc003yfe.1_Missense_Mutation_p.E201K|RUNX1T1_uc010mao.2_Missense_Mutation_p.E211K|RUNX1T1_uc011lgi.1_Missense_Mutation_p.E249K|RUNX1T1_uc003yfb.1_Missense_Mutation_p.E201K|RUNX1T1_uc003yff.1_Missense_Mutation_p.E201K	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	238					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCCCGTTTTCGTTCACATCG	0.542													0	0	0	0.005443	0	26	170										T	93017372	C	T	93017372	3	4	46	1	0	0	0	0	1	0	0	0	13747	893	31	1	1130	1	RUNX1T1	8	93017372	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4132057	93017372	53346650	795	12492										
PTDSS1	9791	broad.mit.edu	37	chr8	97274371	97274371	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagtggaggacatcaccattGacttcttctaccggccgcat	9	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:97274371G>A	uc003yht.1	+	1	205	c.103G>A	c.(103-105)GAC>AAC	p.D35N	MTERFD1_uc003yhs.1_5'Flank|MTERFD1_uc010mbd.1_5'Flank|PTDSS1_uc003yhu.1_5'UTR	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	35					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CATCACCATTGACTTCTTCTA	0.577													0	0	0	0.001855	0	12	57										A	97274371	G	A	97274371	3	1	46	1	0	0	0	0	1	0	0	0	12736	1290	45	1	105	1	PTDSS1	8	97274371	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4256999	97274371	49089651	796	12493										
PGCP	10404	broad.mit.edu	37	chr8	97797339	97797339	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcgattggcacttctggttGatactgttggacccagactg	12	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:97797339G>C	uc003yhw.2	+	2	380	c.214G>C	c.(214-216)GAT>CAT	p.D72H	PGCP_uc010mbe.2_Missense_Mutation_p.D72H	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	72					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					ACTTCTGGTTGATACTGTTGG	0.453													0	0	0	0.00499	0	18	122										C	97797339	G	C	97797339	3	2	46	1	0	0	0	0	1	0	0	0	11786	1290	45	1	216	1	PGCP	8	97797339	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	522968	97797339	48566683	797	12494										
VPS13B	157680	broad.mit.edu	37	chr8	100454826	100454826	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatatggaacctctgcaggaGattccatttgttatcccacg	8	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:100454826G>A	uc003yiv.2	+	23	3519	c.3408G>A	c.(3406-3408)GAG>GAA	p.E1136E	VPS13B_uc003yiw.2_Silent_p.E1136E|VPS13B_uc003yiu.1_Silent_p.E1136E|VPS13B_uc003yix.1_Silent_p.E606E	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1136					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTCTGCAGGAGATTCCATTTG	0.393													0	0	0	0.013537	0	13	52										A	100454826	G	A	100454826	2	1	46	1	0	0	0	0	0	0	0	1	17187	933	33	1		1	VPS13B	8	100454826	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2657487	100454826	45909196	798	12495										
VPS13B	157680	broad.mit.edu	37	chr8	100883099	100883099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgaccaggctccaaacagcCatgtcaaatatgtctggtaa	8	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:100883099C>T	uc003yiv.2	+	60	11665	c.11554C>T	c.(11554-11556)CAT>TAT	p.H3852Y	VPS13B_uc003yiw.2_Missense_Mutation_p.H3827Y	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3852					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCCAAACAGCCATGTCAAATA	0.433													0	0	0	0.006122	0	17	60										T	100883099	C	T	100883099	3	4	46	1	0	0	0	0	1	0	0	0	17187	594	21	2	11982	2	VPS13B	8	100883099	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	428273	100883099	45480923	799	12496										
RNF19A	25897	broad.mit.edu	37	chr8	101300012	101300012	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaaaggcacaaagggcactCtatgaagtctccaatttgtt	8	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:101300012C>T	uc003yjj.1	-	3	708	c.391G>A	c.(391-393)GAG>AAG	p.E131K	RNF19A_uc003yjk.1_Missense_Mutation_p.E131K|RNF19A_uc003yjl.1_Missense_Mutation_p.E131K	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	131					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			AAAGGGCACTCTATGAAGTCT	0.368													0	0	0	0.01441	0	61	231										T	101300012	C	T	101300012	3	4	46	1	0	0	0	0	1	0	0	0	13470	922	32	1	2161	1	RNF19A	8	101300012	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	416913	101300012	45064010	800	12497										
YWHAZ	7534	broad.mit.edu	37	chr8	101932959	101932959	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctgcttcagcttcgtctcCttgggtatccgatgtccaca	8	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:101932959C>G	uc011lhe.1	-	6	877	c.700G>C	c.(700-702)GGA>CGA	p.G234R	YWHAZ_uc003yjv.2_Missense_Mutation_p.G234R|YWHAZ_uc011lhf.1_Missense_Mutation_p.G234R|YWHAZ_uc003yjw.2_Missense_Mutation_p.G234R|YWHAZ_uc010mbq.2_Missense_Mutation_p.G157R|YWHAZ_uc011lhg.1_Missense_Mutation_p.G114R|YWHAZ_uc010mbr.2_Missense_Mutation_p.G234R|YWHAZ_uc003yjx.2_Missense_Mutation_p.G234R	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	234					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	GCTTCGTCTCCTTGGGTATCC	0.458													0	0	0	0.00632	0	21	98										G	101932959	C	G	101932959	3	3	46	1	0	0	0	0	1	0	0	0	17503	690	24	4	41	4	YWHAZ	8	101932959	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	632947	101932959	44431063	801	12498										
ATP6V1C1	528	broad.mit.edu	37	chr8	104080913	104080913	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttccaggtttaaacctgagtCaacaagaatactacccctat	5	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:104080913C>G	uc003ykz.3	+	13	1332	c.1087C>G	c.(1087-1089)CAA>GAA	p.Q363E	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.Q288E|ATP6V1C1_uc003yla.2_Missense_Mutation_p.Q363E|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.Q288E	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	363					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			AAACCTGAGTCAACAAGAATA	0.368													0	0	0	0.006122	0	16	100										G	104080913	C	G	104080913	3	3	46	1	0	0	0	0	1	0	0	0	1180	827	29	1	1133	1	ATP6V1C1	8	104080913	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2147954	104080913	42283109	802	12499										
LRP12	29967	broad.mit.edu	37	chr8	105503092	105503092	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccttgatctgaggcaagatCaagaagaggtctggagcagt	13	7	3	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:105503092C>T	uc003yma.2	-	7	2484	c.2389G>A	c.(2389-2391)GAT>AAT	p.D797N	LRP12_uc003ymb.2_Missense_Mutation_p.D778N|LRP12_uc003ylz.2_Missense_Mutation_p.D203N	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	797	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGGCAAGATCAAGAAGAGGT	0.443													0	0	0	0.003271	0	34	138										T	105503092	C	T	105503092	3	4	46	1	0	0	0	0	1	0	0	0	8954	826	29	1	194	1	LRP12	8	105503092	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1422179	105503092	40860930	803	12500										
ZFPM2	23414	broad.mit.edu	37	chr8	106813421	106813421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgtaatcactgccatttcGgcttccagactcagagggag	11	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:106813421G>A	uc003ymd.2	+	8	1134	c.1111G>A	c.(1111-1113)GGC>AGC	p.G371S	ZFPM2_uc011lhs.1_Missense_Mutation_p.G102S|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	371	C2H2-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTGCCATTTCGGCTTCCAGAC	0.512													0	0	0	0.01441	0	43	193										A	106813421	G	A	106813421	3	1	46	1	0	0	0	0	1	0	0	0	17655	1116	39	2	1141	2	ZFPM2	8	106813421	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1310329	106813421	39550601	804	12501										
OXR1	55074	broad.mit.edu	37	chr8	107719112	107719112	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accaggattcttttcttcatGagaattcgttacaccaagaa	6	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:107719112G>C	uc011lht.1	+	8	1465	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q	OXR1_uc003ymf.2_Missense_Mutation_p.E455Q|OXR1_uc011lhu.1_Missense_Mutation_p.E448Q|OXR1_uc010mcg.2_Intron|OXR1_uc010mch.2_Missense_Mutation_p.E153Q|OXR1_uc003ymg.1_Missense_Mutation_p.E388Q|OXR1_uc003ymi.1_Missense_Mutation_p.E367Q	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	456					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TTTTCTTCATGAGAATTCGTT	0.353													0	0	0	0.01441	0	86	41										C	107719112	G	C	107719112	3	2	46	1	0	0	0	0	1	0	0	0	11334	1291	45	1	1596	1	OXR1	8	107719112	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	905691	107719112	38644910	805	12502										
ANGPT1	284	broad.mit.edu	37	chr8	108509537	108509537	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcacatgttccagatgttGaagtttctgggaagagaaat	10	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:108509537G>A	uc003ymn.2	-	1	718	c.250C>T	c.(250-252)CAA>TAA	p.Q84*	ANGPT1_uc003ymo.2_Nonsense_Mutation_p.Q84*	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	84	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TCCAGATGTTGAAGTTTCTGG	0.448													0	0	0	0.009535	0	30	142										A	108509537	G	A	108509537	4	1	46	1	0	0	0	0	0	1	0	0	610	1299	45	1	1282	1	ANGPT1	8	108509537	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	790425	108509537	37854485	806	12503										
ANGPT1	284	broad.mit.edu	37	chr8	108509747	108509747	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgcaccctatgtgagtcaGaatggcagcgaggaaagcaa	13	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:108509747G>A	uc003ymn.2	-	1	508	c.40C>T	c.(40-42)CTG>TTG	p.L14L	ANGPT1_uc003ymo.2_Silent_p.L14L	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	14					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			ATGTGAGTCAGAATGGCAGCG	0.483													0	0	0	0.00308	0	8	51										A	108509747	G	A	108509747	2	1	46	1	0	0	0	0	0	0	0	1	610	933	33	1		1	ANGPT1	8	108509747	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	210	108509747	37854275	807	12504										
CSMD3	114788	broad.mit.edu	37	chr8	113518955	113518955	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagataacatagtctgcattGacggtgatagtccagtcaca	10	8	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:113518955G>A	uc003ynu.2	-	29	5019	c.4860C>T	c.(4858-4860)GTC>GTT	p.V1620V	CSMD3_uc003yns.2_Silent_p.V892V|CSMD3_uc003ynt.2_Silent_p.V1580V|CSMD3_uc011lhx.1_Silent_p.V1516V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1620	Extracellular (Potential).|CUB 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTCTGCATTGACGGTGATAG	0.393										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004656	0	26	124										A	113518955	G	A	113518955	2	1	46	1	0	0	0	0	0	0	0	1	3946	1277	45	1		1	CSMD3	8	113518955	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5009208	113518955	32845067	808	12505										
UTP23	84294	broad.mit.edu	37	chr8	117782536	117782536	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcatttcaagaatgcagtGagtggatcagaatgtctgct	10	8	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:117782536G>C	uc003yoc.2	+	2	395	c.294G>C	c.(292-294)GTG>GTC	p.V98V		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	98					rRNA processing	nucleolus					0						AGAATGCAGTGAGTGGATCAG	0.383													0	0	0	0.004656	0	27	124										C	117782536	G	C	117782536	2	2	46	1	0	0	0	0	0	0	0	1	17097	1277	45	1		1	UTP23	8	117782536	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4263581	117782536	28581486	809	12506										
HAS2	3037	broad.mit.edu	37	chr8	122629422	122629422	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccacagatgaggctgggtCaagcatagtgtctgaatcac	11	10	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:122629422C>G	uc003yph.2	-	3	1190	c.652G>C	c.(652-654)GAC>CAC	p.D218H		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	218	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GAGGCTGGGTCAAGCATAGTG	0.393													0	0	0	0.004482	0	9	52										G	122629422	C	G	122629422	3	3	46	1	0	0	0	0	1	0	0	0	6962	826	29	1	1014	1	HAS2	8	122629422	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4846886	122629422	23734600	810	12507										
ZHX1	11244	broad.mit.edu	37	chr8	124266210	124266210	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttacatatcttgcctgtactCcctgacttaggtgcaccaga	7	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:124266210C>A	uc003yqe.2	-	3	2407	c.1977G>T	c.(1975-1977)GGG>GGT	p.G659G	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Silent_p.G659G|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Silent_p.G659G	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	659					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGCCTGTACTCCCTGACTTAG	0.438													1	0	1.99824e-07	0.00499	2.05896e-07	16	161										A	124266210	C	A	124266210	2	1	46	1	0	0	0	0	0	0	0	1	17672	842	30	3		3	ZHX1	8	124266210	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1636788	124266210	22097812	811	12508										
EFR3A	23167	broad.mit.edu	37	chr8	132991170	132991170	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggatcctttgttatcaccatCtctcatggaggactacgaac	8	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:132991170C>G	uc003yte.2	+	13	1604	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	468						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTATCACCATCTCTCATGGAG	0.443													0	0	0	0.003271	0	35	141										G	132991170	C	G	132991170	3	3	46	1	0	0	0	0	1	0	0	0	4958	913	32	1	1453	1	EFR3A	8	132991170	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	8724960	132991170	13372852	812	12509										
KHDRBS3	10656	broad.mit.edu	37	chr8	136554899	136554899	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgtttatttttcctagttCaactttgtggggaaactttt	8	5	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:136554899C>G	uc003yuv.2	+	3	604	c.210C>G	c.(208-210)TTC>TTG	p.F70L	KHDRBS3_uc003yuw.2_Missense_Mutation_p.F70L	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	70	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			TTTCCTAGTTCAACTTTGTGG	0.363													0	0	0	0.01441	0	134	81										G	136554899	C	G	136554899	3	3	46	1	0	0	0	0	1	0	0	0	8148	825	29	1	220	1	KHDRBS3	8	136554899	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3563729	136554899	9809123	813	12510										
COL22A1	169044	broad.mit.edu	37	chr8	139648989	139648989	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taaagtaaatttttacctgaTcacctttctgcccaacctca	3	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:139648989T>C	uc003yvd.2	-	48	3998	c.3551A>G	c.(3550-3552)GAT>GGT	p.D1184G	COL22A1_uc011ljo.1_Missense_Mutation_p.D464G	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1184	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTTTACCTGATCACCTTTCTG	0.413										HNSCC(7;0.00092)			0	0	0	0.01441	0	66	342										C	139648989	T	C	139648989	3	2	46	1	0	0	0	0	1	0	0	0	3681	1435	50	5	1401	5	COL22A1	8	139648989	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	3094090	139648989	6715033	814	12511										
ZNF623	9831	broad.mit.edu	37	chr8	144732386	144732386	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaccttcttctgcttcagaGagagctcatagagggggaag	13	8	4	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144732386G>C	uc003yzd.2	+	1	433	c.344G>C	c.(343-345)AGA>ACA	p.R115T	ZNF623_uc011lkp.1_Missense_Mutation_p.R75T|ZNF623_uc003yzc.2_Missense_Mutation_p.R75T	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTGCTTCAGAGAGAGCTCATA	0.478													0	0	0	0.014323	0	18	146										C	144732386	G	C	144732386	3	2	46	1	0	0	0	0	1	0	0	0	18044	942	33	1	346	1	ZNF623	8	144732386	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5083397	144732386	1631636	815	12512										
SCRIB	23513	broad.mit.edu	37	chr8	144895820	144895820	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactcacttgcccacgtcccCgggcagtgcctgcagagaca	10	17	1	1	rs144081360	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144895820C>G	uc003yzp.1	-	4	440	c.433G>C	c.(433-435)GGG>CGG	p.G145R	SCRIB_uc003yzo.1_Missense_Mutation_p.G145R|MIR937_hsa-mir-937|MI0005759_5'Flank	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	145	Sufficient for targeting to adherens junction and to inhibit cell proliferation.|LRR 5.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCCACGTCCCCGGGCAGTGCC	0.642													0	0	0	0.008291	0	9	49										G	144895820	C	G	144895820	3	3	46	1	0	0	0	0	1	0	0	0	13937	652	23	4	4670	4	SCRIB	8	144895820	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	163434	144895820	1468202	816	12513										
PUF60	22827	broad.mit.edu	37	chr8	144898723	144898723	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcactgttatcaaaacgctcCtggtcgtacacttcagccac	6	14	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144898723C>T	uc003yzs.2	-	12	1711	c.1647G>A	c.(1645-1647)CAG>CAA	p.Q549Q	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.Q489Q|PUF60_uc003yzt.2_Silent_p.Q532Q|PUF60_uc003yzq.2_Silent_p.Q506Q	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	549	RRM 3; atypical.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CAAAACGCTCCTGGTCGTACA	0.532													0	0	0	0.01441	0	77	45										T	144898723	C	T	144898723	2	4	46	1	0	0	0	0	0	0	0	1	12824	680	24	2		2	PUF60	8	144898723	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2903	144898723	1465299	817	12514										
EPPK1	83481	broad.mit.edu	37	chr8	144940699	144940699	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctggtagatgctcatcttCtcctggcggccgggctggtc	14	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144940699C>T	uc003zaa.1	-	2	14746	c.14733G>A	c.(14731-14733)GAG>GAA	p.E4911E		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4911	Plectin 61.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCTCATCTTCTCCTGGCGGC	0.697													0	0	0	0.000602	0	5	83										T	144940699	C	T	144940699	2	4	46	1	0	0	0	0	0	0	0	1	5190	912	32	1		1	EPPK1	8	144940699	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	41976	144940699	1423323	818	12515										
PLEC	5339	broad.mit.edu	37	chr8	144991306	144991306	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtcggcgaactcggtgatgGagagcgtgccggcgcggtac	18	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144991306G>A	uc003zaf.1	-	32	13264	c.13094C>T	c.(13093-13095)TCC>TTC	p.S4365F	PLEC_uc003zab.1_Missense_Mutation_p.S4228F|PLEC_uc003zac.1_Missense_Mutation_p.S4232F|PLEC_uc003zad.2_Missense_Mutation_p.S4228F|PLEC_uc003zae.1_Missense_Mutation_p.S4196F|PLEC_uc003zag.1_Missense_Mutation_p.S4206F|PLEC_uc003zah.2_Missense_Mutation_p.S4214F|PLEC_uc003zaj.2_Missense_Mutation_p.S4255F	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4365	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTCGGTGATGGAGAGCGTGCC	0.667													0	0	0	0.001168	0	6	33										A	144991306	G	A	144991306	3	1	46	1	0	0	0	0	1	0	0	0	12052	1174	41	1	964	1	PLEC	8	144991306	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	50607	144991306	1372716	819	12516										
PLEC	5339	broad.mit.edu	37	chr8	144997136	144997136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agccttgagtcgcgtggcctCctgcaccgcctgcatcttct	10	16	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144997136C>T	uc003zaf.1	-	31	7542	c.7372G>A	c.(7372-7374)GAG>AAG	p.E2458K	PLEC_uc003zab.1_Missense_Mutation_p.E2321K|PLEC_uc003zac.1_Missense_Mutation_p.E2325K|PLEC_uc003zad.2_Missense_Mutation_p.E2321K|PLEC_uc003zae.1_Missense_Mutation_p.E2289K|PLEC_uc003zag.1_Missense_Mutation_p.E2299K|PLEC_uc003zah.2_Missense_Mutation_p.E2307K|PLEC_uc003zaj.2_Missense_Mutation_p.E2348K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2458	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCGTGGCCTCCTGCACCGCC	0.662													0	0	0	0.000602	0	4	9										T	144997136	C	T	144997136	3	4	46	1	0	0	0	0	1	0	0	0	12052	864	30	1	6690	1	PLEC	8	144997136	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5830	144997136	1366886	820	12517										
CYC1	1537	broad.mit.edu	37	chr8	145151087	145151087	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctgccacagcatggacttCgtggcctaccgccacctggt	10	16	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145151087C>T	uc003zaz.3	+	3	430	c.387C>T	c.(385-387)TTC>TTT	p.F129F	CYC1_uc003zay.2_Silent_p.F70F	NM_001916	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	129	Cytochrome c.				respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCATGGACTTCGTGGCCTACC	0.612											OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	46	202										T	145151087	C	T	145151087	2	4	46	1	0	0	0	0	0	0	0	1	4135	883	31	1		1	CYC1	8	145151087	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	153951	145151087	1212935	821	12518										
GPR172A	79581	broad.mit.edu	37	chr8	145583548	145583548	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgcctcgaatgtcactttCctgcccttcttgagccacct	7	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145583548C>T	uc003zcc.1	+	3	553	c.396C>T	c.(394-396)TTC>TTT	p.F132F	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Silent_p.F132F|GPR172A_uc003zce.1_Silent_p.F132F|GPR172A_uc010mfy.1_Silent_p.F132F|GPR172A_uc003zcf.1_Silent_p.F132F|GPR172A_uc011llc.1_Silent_p.F44F	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	132	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			ATGTCACTTTCCTGCCCTTCT	0.602													0	0	0	0.007835	0	38	121										T	145583548	C	T	145583548	2	4	46	1	0	0	0	0	0	0	0	1	6669	854	30	1		1	GPR172A	8	145583548	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	432461	145583548	780474	822	12519										
ADCK5	203054	broad.mit.edu	37	chr8	145616165	145616165	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctacgtgaagctgggccaggGgctgtgctccttcaaccacc	12	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145616165G>A	uc003zch.2	+	5	506	c.452G>A	c.(451-453)GGG>GAG	p.G151E	ADCK5_uc003zcg.2_RNA|ADCK5_uc003zci.2_5'Flank	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	151						integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTGGGCCAGGGGCTGTGCTCC	0.662													0	0	0	0.013537	0	11	39										A	145616165	G	A	145616165	3	1	46	1	0	0	0	0	1	0	0	0	291	1232	43	2	470	2	ADCK5	8	145616165	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	32617	145616165	747857	823	12520										
FOXH1	8928	broad.mit.edu	37	chr8	145700598	145700598	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggagtctttccagccctcgTagtcttccctgaagaagggg	12	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145700598T>C	uc003zdc.2	-	2	800	c.221A>G	c.(220-222)TAC>TGC	p.Y74C		NM_003923	NP_003914	O75593	FOXH1_HUMAN	forkhead box H1	74	Fork-head.				axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCAGCCCTCGTAGTCTTCCCT	0.682													0	0	0	0.000602	0	5	17										C	145700598	T	C	145700598	3	2	46	1	0	0	0	0	1	0	0	0	6008	1638	57	5	884	5	FOXH1	8	145700598	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	84433	145700598	663424	824	12521										
ZNF251	90987	broad.mit.edu	37	chr8	145947214	145947214	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgtgagttacctgatgttGaataagggttgactttccac	11	6	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145947214G>T	uc003zdv.3	-	5	2087	c.1831C>A	c.(1831-1833)CAA>AAA	p.Q611K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	611	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ACCTGATGTTGAATAAGGGTT	0.478													1	0	3.05275e-18	0.013114	3.22672e-18	48	33										T	145947214	G	T	145947214	3	4	46	1	0	0	0	0	1	0	0	0	17793	1299	45	3	188	3	ZNF251	8	145947214	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	246616	145947214	416808	825	12522										
SMARCA2	6595	broad.mit.edu	37	chr9	2060921	2060921	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtagccaatctgaccaatCtggtttgggagcacaagcaa	10	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:2060921C>T	uc003zhc.2	+	9	1726	c.1627C>T	c.(1627-1629)CTG>TTG	p.L543L	SMARCA2_uc003zhd.2_Silent_p.L543L|SMARCA2_uc010mha.2_Silent_p.L534L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	543					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TCTGACCAATCTGGTTTGGGA	0.413													0	0	0	0.010729	0	11	56										T	2060921	C	T	2060921	2	4	46	1	0	0	0	0	0	0	0	1	14769	912	32	1		1	SMARCA2	9	2060921	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		2060921	139152510	826	12523										
SMARCA2	6595	broad.mit.edu	37	chr9	2060974	2060974	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagagaagaagaagaggagGaggaggaagaaggtgcgtat	18	1	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:2060974G>T	uc003zhc.2	+	9	1779	c.1680G>T	c.(1678-1680)AGG>AGT	p.R560S	SMARCA2_uc003zhd.2_Missense_Mutation_p.R560S|SMARCA2_uc010mha.2_Missense_Mutation_p.R551S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	560	Poly-Arg.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agaagaggaggaggaggaaga	0.418													1	0	5.45024e-15	0.00333	5.7246e-15	23	25										T	2060974	G	T	2060974	3	4	46	1	0	0	0	0	1	0	0	0	14769	1165	41	3	1710	3	SMARCA2	9	2060974	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	53	2060974	139152457	827	12524										
C9orf68	55064	broad.mit.edu	37	chr9	4661989	4661989	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgattcatgaggtagaccccGaggtacacatcttgtttgcc	10	10	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:4661989G>A	uc011llz.1	-	3	325	c.87C>T	c.(85-87)CTC>CTT	p.L29L	C9orf68_uc003zik.2_RNA|C9orf68_uc003zil.2_RNA|C9orf68_uc010mhj.2_Silent_p.L29L|C9orf68_uc011lly.1_5'UTR|C9orf68_uc003zim.2_Silent_p.L29L|PPAPDC2_uc003zin.2_5'Flank	NM_001039395	NP_001034484	B4DIY4	B4DIY4_HUMAN	hypothetical protein LOC55064	29											0		Breast(48;0.0456)		GBM - Glioblastoma multiforme(50;0.0222)		GGTAGACCCCGAGGTACACAT	0.438											OREG0019084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	50										A	4661989	G	A	4661989	2	1	46	1	0	0	0	0	0	0	0	1	2491	1045	37	1		1	C9orf68	9	4661989	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2601015	4661989	136551442	828	12525										
KIAA1432	57589	broad.mit.edu	37	chr9	5745991	5745991	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatttggttctcaaaacactGaaattgagtctgacctcagg	9	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:5745991G>A	uc003zji.2	+	10	1012	c.919G>A	c.(919-921)GAA>AAA	p.E307K	KIAA1432_uc003zjh.2_Missense_Mutation_p.E307K|KIAA1432_uc003zjl.3_Missense_Mutation_p.E307K|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	386						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TCAAAACACTGAAATTGAGTC	0.418													0	0	0	0.01441	0	77	86										A	5745991	G	A	5745991	3	1	46	1	0	0	0	0	1	0	0	0	8233	1291	45	1	957	1	KIAA1432	9	5745991	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1084002	5745991	135467440	829	12526										
KIAA2026	158358	broad.mit.edu	37	chr9	6007317	6007317	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcaacctgaagtccgccacGaactcggtgatgcccccgta	9	15	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:6007317G>A	uc003zjq.3	-	1	687	c.471C>T	c.(469-471)TTC>TTT	p.F157F		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	157										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AGTCCGCCACGAACTCGGTGA	0.637													0	0	0	0.003163	0	11	48										A	6007317	G	A	6007317	2	1	46	1	0	0	0	0	0	0	0	1	8270	1049	37	1		1	KIAA2026	9	6007317	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	261326	6007317	135206114	830	12527										
GLDC	2731	broad.mit.edu	37	chr9	6605254	6605254	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccatttcacagggtaacttCagctcagtgaggactccagt	9	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:6605254C>T	uc003zkc.2	-	6	931	c.738G>A	c.(736-738)CTG>CTA	p.L246L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	246					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AGGGTAACTTCAGCTCAGTGA	0.433													0	0	0	0.001855	0	14	61										T	6605254	C	T	6605254	2	4	46	1	0	0	0	0	0	0	0	1	6433	813	29	1		1	GLDC	9	6605254	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	597937	6605254	134608177	831	12528										
KDM4C	23081	broad.mit.edu	37	chr9	7174617	7174617	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agacattatccaaggggagaGaaagagacaaagagtgctga	13	5	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:7174617G>C	uc003zkh.2	+	22	3639	c.3059G>C	c.(3058-3060)AGA>ACA	p.R1020T	KDM4C_uc011lmk.1_Missense_Mutation_p.R765T|KDM4C_uc011lml.1_Missense_Mutation_p.R707T	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	1020					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						CAAGGGGAGAGAAAGAGACAA	0.458													0	0	0	0.01441	0	142	57										C	7174617	G	C	7174617	3	2	46	1	0	0	0	0	1	0	0	0	8130	942	33	1	3383	1	KDM4C	9	7174617	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	569363	7174617	134038814	832	12529										
C9orf123	90871	broad.mit.edu	37	chr9	7799696	7799696	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcggtaccgggaggcgcagtGatataggactcaaaaggctg	16	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:7799696G>A	uc003zki.2	-	1	83	c.39C>T	c.(37-39)ATC>ATT	p.I13I	C9orf123_uc003zkj.2_Silent_p.I13I			Q96GE9	CI123_HUMAN	Homo sapiens cDNA FLJ46908 fis, clone FEBRA2004867.	13						integral to membrane					0		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)		GAGGCGCAGTGATATAGGACT	0.637													0	0	0	0.008871	0	21	7										A	7799696	G	A	7799696	2	1	46	1	0	0	0	0	0	0	0	1	2453	1280	45	1		1	C9orf123	9	7799696	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	625079	7799696	133413735	833	12530										
MPDZ	8777	broad.mit.edu	37	chr9	13143491	13143491	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcgttgatttgtagagagtCagcaaatgggttagtgctgc	15	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:13143491C>T	uc010mia.1	-	26	3871	c.3814G>A	c.(3814-3816)GAC>AAC	p.D1272N	MPDZ_uc010mhx.2_Intron|MPDZ_uc011lmm.1_Intron|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.D1272N|MPDZ_uc010mhz.2_Intron|MPDZ_uc011lmn.1_Intron|MPDZ_uc003zlb.3_Missense_Mutation_p.D1272N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1272					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TGTAGAGAGTCAGCAAATGGG	0.428													0	0	0	0.01441	0	82	52										T	13143491	C	T	13143491	3	4	46	1	0	0	0	0	1	0	0	0	9722	826	29	1	2391	1	MPDZ	9	13143491	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5343795	13143491	128069940	834	12531										
DNAJA1	3301	broad.mit.edu	37	chr9	33026956	33026956	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catctttgatatgttttttgGaggaggaggaaggatgcaga	14	3	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:33026956G>A	uc003zsd.1	+	3	461	c.278G>A	c.(277-279)GGA>GAA	p.G93E	DNAJA1_uc011lnt.1_Intron|DNAJA1_uc003zse.1_Missense_Mutation_p.G93E|APTX_uc003zrz.2_5'Flank	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	93	Gly-rich.				protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		ATGTTTTTTGGAGGAGGAGGA	0.438													0	0	0	0.01441	0	60	32										A	33026956	G	A	33026956	3	1	46	1	0	0	0	0	1	0	0	0	4611	1174	41	1	284	1	DNAJA1	9	33026956	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	19883465	33026956	108186475	835	12532										
BAG1	573	broad.mit.edu	37	chr9	33264454	33264454	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcggcgccgggttttcttCttcatccgcggcctgcgagc	14	14	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:33264454C>T	uc003zsj.2	-	1	308	c.219G>A	c.(217-219)AAG>AAA	p.K73K	SUGT1P1_uc010mjq.1_Intron|BAG1_uc003zsi.2_5'UTR|BAG1_uc003zsk.2_5'UTR|CHMP5_uc003zsl.3_5'UTR|CHMP5_uc003zsm.3_5'Flank|CHMP5_uc011lnv.1_5'Flank	NM_004323	NP_004314	Q99933	BAG1_HUMAN	BCL2-associated athanogene isoform 1L	73	Arg-rich.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			GGGTTTTCTTCTTCATCCGCG	0.701													0	0	0	0.00499	0	16	16										T	33264454	C	T	33264454	2	4	46	1	0	0	0	0	0	0	0	1	1286	912	32	1		1	BAG1	9	33264454	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	237498	33264454	107948977	836	12533										
DCAF12	25853	broad.mit.edu	37	chr9	34125197	34125197	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attctgtagcctgacttcccGgttcttcaagtagtatacta	7	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:34125197G>A	uc003ztt.2	-	2	499	c.157C>T	c.(157-159)CGG>TGG	p.R53W		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	53						centrosome|CUL4 RING ubiquitin ligase complex					0						CTGACTTCCCGGTTCTTCAAG	0.453													0	0	0	0.01441	0	75	56										A	34125197	G	A	34125197	3	1	46	1	0	0	0	0	1	0	0	0	4263	1115	39	2	1236	2	DCAF12	9	34125197	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	860743	34125197	107088234	837	12534										
CCL21	6366	broad.mit.edu	37	chr9	34709845	34709845	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggacaaccttggcgggaatCttcctttggctgtacttgag	12	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:34709845C>G	uc003zvo.2	-	2	201	c.117G>C	c.(115-117)AAG>AAC	p.K39N		NM_002989	NP_002980	O00585	CCL21_HUMAN	small inducible cytokine A21 precursor	39					activation of Rho GTPase activity|cell maturation|cell-cell signaling|dendritic cell chemotaxis|dendritic cell dendrite assembly|establishment of T cell polarity|immune response|immunological synapse formation|inflammatory response|mesangial cell-matrix adhesion|negative regulation of leukocyte apoptosis|positive regulation of actin filament polymerization|positive regulation of cell adhesion mediated by integrin|positive regulation of cell-matrix adhesion|positive regulation of dendritic cell antigen processing and presentation|positive regulation of ERK1 and ERK2 cascade|positive regulation of filopodium assembly|positive regulation of glycoprotein biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of myeloid dendritic cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of pseudopodium assembly|positive regulation of receptor-mediated endocytosis|release of sequestered calcium ion into cytosol|response to prostaglandin E stimulus|ruffle organization|T cell costimulation	extracellular space	CCR7 chemokine receptor binding|chemokine activity				0	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		TGGCGGGAATCTTCCTTTGGC	0.592													0	0	0	0.01441	0	61	23										G	34709845	C	G	34709845	3	3	46	1	0	0	0	0	1	0	0	0	2893	912	32	1	299	1	CCL21	9	34709845	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	584648	34709845	106503586	838	12535										
CREB3	10488	broad.mit.edu	37	chr9	35732998	35732998	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaaccctgcgcaggtaccGagcgactgggaagtagatga	15	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:35732998G>A	uc003zxv.2	+	2	588	c.135G>A	c.(133-135)CCG>CCA	p.P45P	TLN1_uc003zxt.2_5'Flank|TLN1_uc003zxu.3_5'Flank|CREB3_uc010mla.2_5'UTR	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	45	Cytoplasmic (Potential).|Transcription activation (acidic).				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		CGCAGGTACCGAGCGACTGGG	0.562													0	0	0	0.01441	0	79	38										A	35732998	G	A	35732998	2	1	46	1	0	0	0	0	0	0	0	1	3855	1045	37	1		1	CREB3	9	35732998	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1023153	35732998	105480433	839	12536										
ZBTB5	9925	broad.mit.edu	37	chr9	37441574	37441574	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcagatttaaccaccactctCatgtgctccttctcaccaag	4	15	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:37441574C>T	uc003zzx.2	-	2	1175	c.975G>A	c.(973-975)ATG>ATA	p.M325I		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		CCACCACTCTCATGTGCTCCT	0.507													0	0	0	0.009535	0	28	169										T	37441574	C	T	37441574	3	4	46	1	0	0	0	0	1	0	0	0	17548	826	29	1	1062	1	ZBTB5	9	37441574	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1708576	37441574	103771857	840	12537										
DCAF10	79269	broad.mit.edu	37	chr9	37842126	37842126	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgctacctgctctgatgacActacaatagcactatgggat	8	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:37842126A>T	uc004aao.2	+	3	768	c.694A>T	c.(694-696)ACT>TCT	p.T232S	DCAF10_uc010mlz.2_Missense_Mutation_p.T59S	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	232	WD 2.					CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						CTCTGATGACACTACAATAGC	0.358													0	0	0	0.01441	0	97	49										T	37842126	A	T	37842126	3	4	46	1	0	0	0	0	1	0	0	0	4261	159	6	5	704	5	DCAF10	9	37842126	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	400552	37842126	103371305	841	12538										
PTAR1	375743	broad.mit.edu	37	chr9	72349085	72349085	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgtgaatccatgtttctgGactctttggaaacttggtta	9	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:72349085G>A	uc004ahj.3	-	4	431	c.409C>T	c.(409-411)CCA>TCA	p.P137S	PTAR1_uc004ahi.2_Missense_Mutation_p.P58S	NM_001099666	NP_001093136	Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat	137	PFTA 2.				protein prenylation		protein prenyltransferase activity			central_nervous_system(1)	1						CATGTTTCTGGACTCTTTGGA	0.388													0	0	0	0.013726	0	35	40										A	72349085	G	A	72349085	3	1	46	1	0	0	0	0	1	0	0	0	12724	1174	41	1	819	1	PTAR1	9	72349085	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	34506959	72349085	68864346	842	12539										
SMC5	23137	broad.mit.edu	37	chr9	72930468	72930468	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaagttcctgtaggaactGaaaagaccagagaaagaatt	10	5	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:72930468G>A	uc004ahr.2	+	13	1897	c.1780G>A	c.(1780-1782)GAA>AAA	p.E594K		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	594	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						TGTAGGAACTGAAAAGACCAG	0.353													0	0	0	0.01441	0	50	49										A	72930468	G	A	72930468	3	1	46	1	0	0	0	0	1	0	0	0	14786	1291	45	1	1830	1	SMC5	9	72930468	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	581383	72930468	68282963	843	12540										
ALDH1A1	216	broad.mit.edu	37	chr9	75567869	75567869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accttagtatattgaatcttCaaatcggtgagtaggacagg	10	6	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:75567869C>T	uc004ajd.2	-	1	101	c.48G>A	c.(46-48)TTG>TTA	p.L16L	ALDH1A1_uc011lsh.1_Intron	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	16					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	ATTGAATCTTCAAATCGGTGA	0.403													0	0	0	0.003954	0	23	44										T	75567869	C	T	75567869	2	4	46	1	0	0	0	0	0	0	0	1	490	825	29	1		1	ALDH1A1	9	75567869	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2637401	75567869	65645562	844	12541										
TRPM6	140803	broad.mit.edu	37	chr9	77354857	77354857	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctcccacgctgagaccaagAggacatgcttttatcaaggt	9	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:77354857A>G	uc004ajl.1	-	34	5507	c.5269T>C	c.(5269-5271)TCT>CCT	p.S1757P	TRPM6_uc004ajk.1_Missense_Mutation_p.S1752P|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.S708P|TRPM6_uc010mpd.1_Missense_Mutation_p.S590P|TRPM6_uc010mpe.1_Missense_Mutation_p.S304P|TRPM6_uc004ajj.1_Missense_Mutation_p.S713P	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1757	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGAGACCAAGAGGACATGCTT	0.493													0	0	0	0.004878	0	37	50										G	77354857	A	G	77354857	3	3	46	1	0	0	0	0	1	0	0	0	16587	304	11	5	823	5	TRPM6	9	77354857	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1786988	77354857	63858574	845	12542										
OSTF1	26578	broad.mit.edu	37	chr9	77732450	77732450	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtcttcagagccctgtataCgtttgaacccagaactgtaa	8	10	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:77732450C>T	uc004ajv.3	+	2	276	c.65C>T	c.(64-66)ACG>ATG	p.T22M	OSTF1_uc004ajw.3_Intron|OSTF1_uc004ajx.3_Missense_Mutation_p.T25M	NM_012383	NP_036515	Q92882	OSTF1_HUMAN	osteoclast stimulating factor 1	22	SH3.				ossification|signal transduction	cytoplasm	identical protein binding			skin(1)	1						GCCCTGTATACGTTTGAACCC	0.254													0	0	0	0.00245	0	14	96										T	77732450	C	T	77732450	3	4	46	1	0	0	0	0	1	0	0	0	11297	536	19	2	71	2	OSTF1	9	77732450	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	377593	77732450	63480981	846	12543										
GNA14	9630	broad.mit.edu	37	chr9	80262634	80262634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgcgtccttcttgtcccgacGaagctgtcgctcgatctccg	10	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:80262634G>A	uc004aku.2	-	1	599	c.76C>T	c.(76-78)CGT>TGT	p.R26C		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	26					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TTGTCCCGACGAAGCTGTCGC	0.657													0	0	0	0.009096	0	3	9										A	80262634	G	A	80262634	3	1	46	1	0	0	0	0	1	0	0	0	6502	1058	37	1	1019	1	GNA14	9	80262634	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2530184	80262634	60950797	847	12544										
GNA14	9630	broad.mit.edu	37	chr9	80262682	80262682	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgctgcgactccttctcctCcgcggacaggcagcagcagc	12	17	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:80262682C>T	uc004aku.2	-	1	551	c.28G>A	c.(28-30)GAG>AAG	p.E10K		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	10					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TCCTTCTCCTCCGCGGACAGG	0.701													0	0	0	0.000602	0	4	7										T	80262682	C	T	80262682	3	4	46	1	0	0	0	0	1	0	0	0	6502	864	30	1	1067	1	GNA14	9	80262682	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	48	80262682	60950749	848	12545										
TLE1	7088	broad.mit.edu	37	chr9	84202699	84202699	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagcttggtgccatcattaGaaatgtcaatacagctggct	10	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:84202699G>C	uc004aly.2	-	17	2315	c.1874C>G	c.(1873-1875)TCT>TGT	p.S625C	TLE1_uc004alz.2_Missense_Mutation_p.S635C|TLE1_uc011lsr.1_Missense_Mutation_p.S610C	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	625	WD 4.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GCCATCATTAGAAATGTCAAT	0.532													0	0	0	0.013114	0	47	23										C	84202699	G	C	84202699	3	2	46	1	0	0	0	0	1	0	0	0	15935	942	33	1	454	1	TLE1	9	84202699	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3940017	84202699	57010732	849	12546										
HNRNPK	3190	broad.mit.edu	37	chr9	86587870	86587870	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcattcctggaaaagcttGatggtggtttgagtgttctg	13	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:86587870G>C	uc004ang.3	-	10	758	c.534C>G	c.(532-534)ATC>ATG	p.I178M	HNRNPK_uc011lsw.1_Translation_Start_Site|HNRNPK_uc004and.3_Translation_Start_Site|HNRNPK_uc004ank.3_Missense_Mutation_p.I178M|HNRNPK_uc004anf.3_Missense_Mutation_p.I178M|HNRNPK_uc004anh.3_Missense_Mutation_p.I154M|HNRNPK_uc011lsx.1_Missense_Mutation_p.I154M|HNRNPK_uc004ani.3_Missense_Mutation_p.I178M|HNRNPK_uc004anj.3_Missense_Mutation_p.I178M|HNRNPK_uc004ann.3_Missense_Mutation_p.I154M|HNRNPK_uc004anl.3_Missense_Mutation_p.I178M|HNRNPK_uc004anm.3_Missense_Mutation_p.I178M	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	178	5 X 4 AA repeats of G-X-G-G.|Necessary for interaction with DDX1.|2 X 22 AA approximate repeats.|Interaction with ASFV p30.|KH 2.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGAAAAGCTTGATGGTGGTTT	0.353													0	0	0	0.010504	0	21	95										C	86587870	G	C	86587870	3	2	46	1	0	0	0	0	1	0	0	0	7269	1280	45	1	927	1	HNRNPK	9	86587870	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2385171	86587870	54625561	850	12547										
SLC28A3	64078	broad.mit.edu	37	chr9	86912168	86912168	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagtggtctttgtatttctCaccaaagacaaatgaagcac	8	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:86912168C>T	uc010mpz.2	-	8	954	c.829G>A	c.(829-831)GAG>AAG	p.E277K	SLC28A3_uc011lsy.1_Missense_Mutation_p.E208K|SLC28A3_uc004anu.1_Missense_Mutation_p.E277K|SLC28A3_uc010mqb.2_Missense_Mutation_p.E208K	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	277	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TTGTATTTCTCACCAAAGACA	0.373													0	0	0	0.01441	0	52	43										T	86912168	C	T	86912168	3	4	46	1	0	0	0	0	1	0	0	0	14533	835	29	1	1290	1	SLC28A3	9	86912168	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	324298	86912168	54301263	851	12548										
ZCCHC6	79670	broad.mit.edu	37	chr9	88958054	88958054	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacccaatctgctacaggatGacccatataatcttagggaa	7	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:88958054G>A	uc004aoq.2	-	6	1237	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.S341L|ZCCHC6_uc004aou.2_Missense_Mutation_p.S341L|ZCCHC6_uc004aov.2_Missense_Mutation_p.S341L|ZCCHC6_uc004aow.2_Missense_Mutation_p.S341L	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	341					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						GCTACAGGATGACCCATATAA	0.299													0	0	0	0.00632	0	30	88										A	88958054	G	A	88958054	3	1	46	1	0	0	0	0	1	0	0	0	17589	1294	45	1	3553	1	ZCCHC6	9	88958054	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2045886	88958054	52255377	852	12549										
C9orf79	286234	broad.mit.edu	37	chr9	90500387	90500387	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacatggcaaatcccagccaCggcatcttcccgaccacacc	6	19	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:90500387C>T	uc004app.3	+	4	1020	c.985C>T	c.(985-987)CGG>TGG	p.R329W	C9orf79_uc004apo.1_Missense_Mutation_p.R141W	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	329						integral to membrane				ovary(3)	3						ATCCCAGCCACGGCATCTTCC	0.617													0	0	0	0.010504	0	18	10										T	90500387	C	T	90500387	3	4	46	1	0	0	0	0	1	0	0	0	2497	527	19	2	999	2	C9orf79	9	90500387	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1542333	90500387	50713044	853	12550										
SEMA4D	10507	broad.mit.edu	37	chr9	91994364	91994364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaccccactgtctccttctGacaagttgaagatgagcaag	8	12	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:91994364G>A	uc004aqo.1	-	18	2416	c.1844C>T	c.(1843-1845)TCA>TTA	p.S615L	SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Missense_Mutation_p.S613L	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	615	Ig-like C2-type.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GTCTCCTTCTGACAAGTTGAA	0.527													0	0	0	0.01441	0	302	175										A	91994364	G	A	91994364	3	1	46	1	0	0	0	0	1	0	0	0	14034	1294	45	1	1318	1	SEMA4D	9	91994364	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1493977	91994364	49219067	854	12551										
GADD45G	10912	broad.mit.edu	37	chr9	92220696	92220696	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctgctgcgagaacgacatCgacatagtgcgcgtgggcga	14	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:92220696C>T	uc004aqq.2	+	3	380	c.270C>T	c.(268-270)ATC>ATT	p.I90I	GADD45G_uc004aqr.2_Silent_p.I72I	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	90					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						AGAACGACATCGACATAGTGC	0.647													0	0	0	0.001855	0	13	33										T	92220696	C	T	92220696	2	4	46	1	0	0	0	0	0	0	0	1	6183	874	31	1		1	GADD45G	9	92220696	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	226332	92220696	48992735	855	12552										
BICD2	23299	broad.mit.edu	37	chr9	95482795	95482795	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagcatcgtcactgaacttGaggccatccagcgagacatg	11	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:95482795G>C	uc004aso.1	-	4	906	c.849C>G	c.(847-849)CTC>CTG	p.L283L	BICD2_uc004asp.1_Silent_p.L283L	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	283					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						CACTGAACTTGAGGCCATCCA	0.577													0	0	0	0.00874	0	43	35										C	95482795	G	C	95482795	2	2	46	1	0	0	0	0	0	0	0	1	1429	1277	45	1		1	BICD2	9	95482795	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3262099	95482795	45730636	856	12553										
WNK2	65268	broad.mit.edu	37	chr9	96024958	96024958	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtgtttatttcaggagcagGcctcacaggacaagccgccc	12	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:96024958G>A	uc004ati.1	+	13	3367	c.3367G>A	c.(3367-3369)GCC>ACC	p.A1123T	WNK2_uc011lud.1_Missense_Mutation_p.A1123T|WNK2_uc004atj.2_Missense_Mutation_p.A1123T|WNK2_uc004atk.2_Missense_Mutation_p.A760T	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1123					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TCAGGAGCAGGCCTCACAGGA	0.637													0	0	0	0.001984	0	6	29										A	96024958	G	A	96024958	3	1	46	1	0	0	0	0	1	0	0	0	17375	1203	42	2	3417	2	WNK2	9	96024958	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	542163	96024958	45188473	857	12554										
BARX1	56033	broad.mit.edu	37	chr9	96714549	96714549	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgctcgctcgttggaattGagttcttcttgggccgcccc	12	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:96714549G>C	uc010mrh.2	-	4	842	c.662C>G	c.(661-663)TCA>TGA	p.S221*	BARX1_uc004aud.2_Nonsense_Mutation_p.S67*	NM_021570	NP_067545	Q9HBU1	BARX1_HUMAN	BARX homeobox 1	221						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGTTGGAATTGAGTTCTTCTT	0.687													0	0	0	0.000602	0	5	16										C	96714549	G	C	96714549	4	2	46	1	0	0	0	0	0	1	0	0	1315	1294	45	1	106	1	BARX1	9	96714549	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	689591	96714549	44498882	858	12555										
C9orf156	51531	broad.mit.edu	37	chr9	100672824	100672824	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attttgcggtgagtcatactCagctatgtagggcttgatgt	12	6	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:100672824C>T	uc004axv.1	-	4	561	c.484G>A	c.(484-486)GAG>AAG	p.E162K	C9orf156_uc004axw.1_Missense_Mutation_p.E59K|C9orf156_uc004axx.1_Missense_Mutation_p.E16K|C9orf156_uc010msq.1_Missense_Mutation_p.E59K	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	162					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				GAGTCATACTCAGCTATGTAG	0.413													0	0	0	0.011902	0	44	28										T	100672824	C	T	100672824	3	4	46	1	0	0	0	0	1	0	0	0	2465	835	29	1	849	1	C9orf156	9	100672824	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3958275	100672824	40540607	859	12556										
COL15A1	1306	broad.mit.edu	37	chr9	101767278	101767278	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggccagtggtgtggccccCggggagctggacctctccat	16	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:101767278C>A	uc004azb.1	+	9	1505	c.1299C>A	c.(1297-1299)CCC>CCA	p.P433P		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	433	Nonhelical region 1 (NC1).|4 X tandem repeats.|2.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GTGTGGCCCCCGGGGAGCTGG	0.627													1	0	0.004672	0.004672	0.0047375	3	70										A	101767278	C	A	101767278	2	1	46	1	0	0	0	0	0	0	0	1	3672	639	23	4		4	COL15A1	9	101767278	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1094454	101767278	39446153	860	12557										
ALG2	85365	broad.mit.edu	37	chr9	101980576	101980576	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagaaagacctcaagaaggtCacatactggccaaggtcgga	12	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:101980576C>T	uc004azf.2	-	2	961	c.891G>A	c.(889-891)GTG>GTA	p.V297V	ALG2_uc004azg.2_Silent_p.V204V	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	297					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				TCAAGAAGGTCACATACTGGC	0.478													0	0	0	0.012319	0	22	90										T	101980576	C	T	101980576	2	4	46	1	0	0	0	0	0	0	0	1	519	813	29	1		1	ALG2	9	101980576	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	213298	101980576	39232855	861	12558										
CYLC2	1539	broad.mit.edu	37	chr9	105767772	105767772	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagacagtgactcaaaggatGatgtcaagaaagagtctaag	11	6	3	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:105767772G>A	uc004bbs.2	+	5	929	c.859G>A	c.(859-861)GAT>AAT	p.D287N		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	287	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				CTCAAAGGATgatgtcaagaa	0.234													0	0	0	0.007413	0	20	20										A	105767772	G	A	105767772	3	1	46	1	0	0	0	0	1	0	0	0	4142	1290	45	1	877	1	CYLC2	9	105767772	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3787196	105767772	35445659	862	12559										
ABCA1	19	broad.mit.edu	37	chr9	107588035	107588035	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaacagcatcatggagaccGaagtggtgagattgaagcca	12	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:107588035G>A	uc004bcl.2	-	17	2784	c.2471C>T	c.(2470-2472)TCG>TTG	p.S824L		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	824					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CATGGAGACCGAAGTGGTGAG	0.498													0	0	0	0.01441	0	74	35										A	107588035	G	A	107588035	3	1	46	1	0	0	0	0	1	0	0	0	28	1059	37	1	4450	1	ABCA1	9	107588035	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1820263	107588035	33625396	863	12560										
KIAA0368	23392	broad.mit.edu	37	chr9	114195538	114195538	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgcttttcaattccaggtCtgctgccgttgccacactgt	8	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:114195538C>T	uc004bfe.1	-	9	1357	c.1357G>A	c.(1357-1359)GAC>AAC	p.D453N	KIAA0368_uc010muc.1_Missense_Mutation_p.D275N	NM_001080398	NP_001073867			KIAA0368 protein												0						AATTCCAGGTCTGCTGCCGTT	0.413													0	0	0	0.008871	0	18	81										T	114195538	C	T	114195538	3	4	46	1	0	0	0	0	1	0	0	0	8171	913	32	1	4868	1	KIAA0368	9	114195538	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6607503	114195538	27017893	864	12561										
C9orf43	257169	broad.mit.edu	37	chr9	116187324	116187324	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcactgcgatatcctgaacGtttgaagaaattacataacc	7	9	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:116187324G>T	uc004bho.3	+	9	1229	c.833G>T	c.(832-834)CGT>CTT	p.R278L	C9orf43_uc004bhp.2_Missense_Mutation_p.R278L	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	278											0						TATCCTGAACGTTTGAAGAAA	0.408													1	0	6.57855e-14	0.009718	6.89635e-14	43	46										T	116187324	G	T	116187324	3	4	46	1	0	0	0	0	1	0	0	0	2483	1145	40	4	863	4	C9orf43	9	116187324	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1991786	116187324	25026107	865	12562										
COL27A1	85301	broad.mit.edu	37	chr9	116925054	116925054	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcacctggcctccacccaagGagctcctgaaggtaattctc	8	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:116925054G>A	uc011lxl.1	+	2	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E		NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	41					cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TCCACCCAAGGAGCTCCTGAA	0.557													0	0	0	0.01441	0	80	61										A	116925054	G	A	116925054	3	1	46	1	0	0	0	0	1	0	0	0	3685	1174	41	1	128	1	COL27A1	9	116925054	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	737730	116925054	24288377	866	12563										
ATP6V1G1	9550	broad.mit.edu	37	chr9	117359915	117359915	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acccaggagaagatgaccatCctccagacatacttccggca	8	14	0	4	rs112425042		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:117359915C>T	uc004bjc.2	+	3	374	c.249C>T	c.(247-249)ATC>ATT	p.I83I		NM_004888	NP_004879	O75348	VATG1_HUMAN	vacuolar H+ ATPase G1	83					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances				0						AGATGACCATCCTCCAGACAT	0.512													0	0	0	0.00278	0	22	71										T	117359915	C	T	117359915	2	4	46	1	0	0	0	0	0	0	0	1	1186	845	30	1		1	ATP6V1G1	9	117359915	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	434861	117359915	23853516	867	12564										
CEP110	11064	broad.mit.edu	37	chr9	123924225	123924225	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaagggtatctgaattagaGaagactcaggtggcagtgct	13	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:123924225G>A	uc004bkx.1	+	31	5212	c.5181G>A	c.(5179-5181)GAG>GAA	p.E1727E	CEP110_uc004blb.1_Silent_p.E396E|CEP110_uc010mvp.1_Intron	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1727	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						CTGAATTAGAGAAGACTCAGG	0.388													0	0	0	0.01441	0	57	52										A	123924225	G	A	123924225	2	1	46	1	0	0	0	0	0	0	0	1	3245	933	33	1		1	CEP110	9	123924225	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6564310	123924225	17289206	868	12565										
RBM18	92400	broad.mit.edu	37	chr9	125023758	125023758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctccaggggaagagttttgGtttctgcttccatcaatgtc	10	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:125023758G>A	uc004bma.2	-	2	180	c.14C>T	c.(13-15)ACC>ATC	p.T5I	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	5							nucleotide binding|RNA binding				0						AAGAGTTTTGGTTTCTGCTTC	0.448													0	0	0	0.005524	0	38	27										A	125023758	G	A	125023758	3	1	46	1	0	0	0	0	1	0	0	0	13120	1261	44	2	578	2	RBM18	9	125023758	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1099533	125023758	16189673	869	12566										
PPP6C	5537	broad.mit.edu	37	chr9	127915852	127915852	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaaaagccaacctgctcctCggggactgatagcccaggta	10	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:127915852C>T	uc004bpg.3	-	6	850	c.629G>A	c.(628-630)CGA>CAA	p.R210Q	PPP6C_uc010mwv.2_Missense_Mutation_p.R247Q|PPP6C_uc010mww.2_Missense_Mutation_p.R188Q|PPP6C_uc011lzr.1_Missense_Mutation_p.R63Q	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	210					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						ACCTGCTCCTCGGGGACTGAT	0.443													0	0	0	0.006214	0	10	71										T	127915852	C	T	127915852	3	4	46	1	0	0	0	0	1	0	0	0	12407	884	31	1	296	1	PPP6C	9	127915852	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2892094	127915852	13297579	870	12567										
GARNL3	84253	broad.mit.edu	37	chr9	130027210	130027210	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agatcgctatgtataatactGatgaagcatttttgttccag	8	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130027210G>A	uc011mae.1	+	1	455	c.54G>A	c.(52-54)CTG>CTA	p.L18L	GARNL3_uc011mad.1_Intron	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	18					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTATAATACTGATGAAGCATT	0.453													0	0	0	0.011902	0	45	179										A	130027210	G	A	130027210	2	1	46	1	0	0	0	0	0	0	0	1	6241	1277	45	1		1	GARNL3	9	130027210	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2111358	130027210	11186221	871	12568										
GARNL3	84253	broad.mit.edu	37	chr9	130083018	130083018	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaatctggacaaatttgaGaaaggccccagggaaatttt	10	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130083018G>A	uc011mae.1	+	6	929	c.528G>A	c.(526-528)GAG>GAA	p.E176E	GARNL3_uc011mad.1_Silent_p.E154E	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	176					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ACAAATTTGAGAAAGGCCCCA	0.358													0	0	0	0.004482	0	8	62										A	130083018	G	A	130083018	2	1	46	1	0	0	0	0	0	0	0	1	6241	933	33	1		1	GARNL3	9	130083018	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	55808	130083018	11130413	872	12569										
ENG	2022	broad.mit.edu	37	chr9	130592029	130592029	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagacactgctgtttacactGaggaccagaagcacctctcg	9	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130592029G>A	uc004bsj.3	-	3	710	c.297C>T	c.(295-297)CTC>CTT	p.L99L	ENG_uc011mam.1_5'UTR|ENG_uc004bsk.3_Silent_p.L99L	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	99	Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						TGTTTACACTGAGGACCAGAA	0.602									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.004482	0	8	31										A	130592029	G	A	130592029	2	1	46	1	0	0	0	0	0	0	0	1	5117	1277	45	1		1	ENG	9	130592029	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	509011	130592029	10621402	873	12570										
DNM1	1759	broad.mit.edu	37	chr9	130981398	130981398	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggaccaacctcccgacatCgagttccagatccgagacat	10	14	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130981398C>T	uc011mau.1	+	4	543	c.456C>T	c.(454-456)ATC>ATT	p.I152I	DNM1_uc010mxr.2_Silent_p.I152I|DNM1_uc011mat.1_Silent_p.I152I	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	152					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						CTCCCGACATCGAGTTCCAGA	0.617													0	0	0	0.003755	0	37	115										T	130981398	C	T	130981398	2	4	46	1	0	0	0	0	0	0	0	1	4670	874	31	1		1	DNM1	9	130981398	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	389369	130981398	10232033	874	12571										
GOLGA2	2801	broad.mit.edu	37	chr9	131019547	131019547	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccacactgccggcgaggctCacctcgcaaagatctttgga	10	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131019547C>T	uc011maw.1	-	26	2821	c.2808G>A	c.(2806-2808)GTG>GTA	p.V936V	GOLGA2_uc010mxw.2_Silent_p.V259V|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	936						Golgi cisterna membrane	protein binding			ovary(1)	1						CGGCGAGGCTCACCTCGCAAA	0.637													0	0	0	0.00874	0	33	22										T	131019547	C	T	131019547	2	4	46	1	0	0	0	0	0	0	0	1	6552	813	29	1		1	GOLGA2	9	131019547	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	38149	131019547	10193884	875	12572										
CERCAM	51148	broad.mit.edu	37	chr9	131197963	131197963	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggcacacttctggccacggGacctggtggccttctccgcc	12	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131197963G>A	uc004buz.3	+	12	1965	c.1567G>A	c.(1567-1569)GAC>AAC	p.D523N	CERCAM_uc004buy.1_Missense_Mutation_p.D445N|CERCAM_uc010mxz.2_Missense_Mutation_p.D445N	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	523					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						CTGGCCACGGGACCTGGTGGC	0.657													0	0	0	0.001984	0	7	25										A	131197963	G	A	131197963	3	1	46	1	0	0	0	0	1	0	0	0	3266	1174	41	1	1613	1	CERCAM	9	131197963	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	178416	131197963	10015468	876	12573										
NUP188	23511	broad.mit.edu	37	chr9	131749135	131749135	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgatactgaacctgtgccacGagacagacctgcacagcagg	11	13	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131749135G>A	uc004bws.1	+	22	2267	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	NUP188_uc004bwu.2_Missense_Mutation_p.E92K	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	749					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CCTGTGCCACGAGACAGACCT	0.507													0	0	0	0.013537	0	12	102										A	131749135	G	A	131749135	3	1	46	1	0	0	0	0	1	0	0	0	10758	1059	37	1	2331	1	NUP188	9	131749135	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	551172	131749135	9464296	877	12574										
DOLPP1	57171	broad.mit.edu	37	chr9	131843464	131843464	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatggcggccggtgaccctCacccacgtcgaatatcctgc	10	16	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131843464C>T	uc004bxc.2	+	1	82	c.54C>T	c.(52-54)CTC>CTT	p.L18L	DOLPP1_uc004bxd.2_Silent_p.L18L|DOLPP1_uc004bxe.2_RNA	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	18					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						CGGTGACCCTCACCCACGTCG	0.682													0	0	0	0.010729	0	8	38										T	131843464	C	T	131843464	2	4	46	1	0	0	0	0	0	0	0	1	4704	813	29	1		1	DOLPP1	9	131843464	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	94329	131843464	9369967	878	12575										
EXOSC2	23404	broad.mit.edu	37	chr9	133569207	133569207	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggagatgaggcttccagtggCtcgcaagcctcttagcgaga	14	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:133569207C>T	uc004bzu.2	+	1	50	c.29C>T	c.(28-30)GCT>GTT	p.A10V	EXOSC2_uc011mbz.1_Missense_Mutation_p.A10V|EXOSC2_uc011mca.1_RNA	NM_014285	NP_055100	Q13868	EXOS2_HUMAN	exosome component 2	10					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of cell growth|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|7S RNA binding|protein binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(13;0.0588)		OV - Ovarian serous cystadenocarcinoma(145;0.000324)		CTTCCAGTGGCTCGCAAGCCT	0.587													0	0	0	0.001984	0	5	12										T	133569207	C	T	133569207	3	4	46	1	0	0	0	0	1	0	0	0	5315	797	28	2	31	2	EXOSC2	9	133569207	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1725743	133569207	7644224	879	12576										
FIBCD1	84929	broad.mit.edu	37	chr9	133799256	133799256	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggacgtccagacagtctcGgggccgggagcctgagggag	19	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:133799256G>A	uc004bzz.2	-	4	969	c.724C>T	c.(724-726)CGA>TGA	p.R242*	FIBCD1_uc011mcc.1_Nonsense_Mutation_p.R242*	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	242	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		AGACAGTCTCGGGGCCGGGAG	0.632													0	0	0	0.004007	0	13	33										A	133799256	G	A	133799256	4	1	46	1	0	0	0	0	0	1	0	0	5884	1124	39	2	677	2	FIBCD1	9	133799256	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	230049	133799256	7414175	880	12577										
BAT2L1	84726	broad.mit.edu	37	chr9	134340375	134340375	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcaggcacgaaaggcaggtGaggcccggaagcaggcagag	18	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:134340375G>A	uc004can.3	+	11	1685	c.1630G>A	c.(1630-1632)GAG>AAG	p.E544K	BAT2L1_uc010mzj.1_Missense_Mutation_p.E127K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	544	Potential.						protein binding				0						AAAGGCAGGTGAGGCCCGGAA	0.612													0	0	0	0.000602	0	5	30										A	134340375	G	A	134340375	3	1	46	1	0	0	0	0	1	0	0	0	1320	1291	45	1	1672	1	BAT2L1	9	134340375	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	541119	134340375	6873056	881	12578										
GTF3C5	9328	broad.mit.edu	37	chr9	135906463	135906463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtggagctgaggcgggagcGacgcatggtgtgcgtggagt	21	7	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:135906463G>A	uc004cci.3	+	1	402	c.65G>A	c.(64-66)CGA>CAA	p.R22Q	GTF3C5_uc010mzz.2_5'UTR|GTF3C5_uc004ccj.3_Missense_Mutation_p.R22Q	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	22						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		AGGCGGGAGCGACGCATGGTG	0.721													0	0	0	0.000602	0	5	15										A	135906463	G	A	135906463	3	1	46	1	0	0	0	0	1	0	0	0	6876	1058	37	1	67	1	GTF3C5	9	135906463	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1566088	135906463	5306968	882	12579										
SURF2	6835	broad.mit.edu	37	chr9	136226921	136226921	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agatggacggtgacgggcctCgcccgcgggaagccttctgg	17	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:136226921C>T	uc004cdi.2	+	4	481	c.433C>T	c.(433-435)CGC>TGC	p.R145C		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	145							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		TGACGGGCCTCGCCCGCGGGA	0.627													0	0	0	0.008871	0	19	11										T	136226921	C	T	136226921	3	4	46	1	0	0	0	0	1	0	0	0	15401	884	31	1	447	1	SURF2	9	136226921	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	320458	136226921	4986510	883	12580										
DBH	1621	broad.mit.edu	37	chr9	136507542	136507542	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaccacgtactggtgctacAttaaggagcttccaaagggc	11	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:136507542A>G	uc004cel.2	+	3	709	c.700A>G	c.(700-702)ATT>GTT	p.I234V		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	234	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CTGGTGCTACATTAAGGAGCT	0.607													0	0	0	0.010729	0	12	10										G	136507542	A	G	136507542	3	3	46	1	0	0	0	0	1	0	0	0	4250	217	8	5	710	5	DBH	9	136507542	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	280621	136507542	4705889	884	12581										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													0	0	0	0.01441	0	50	44										T	137328351	C	T	137328351	3	4	46	1	0	0	0	0	1	0	0	0	13763	855	30	1	1318	1	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	820809	137328351	3885080	885	12582										
SOHLH1	402381	broad.mit.edu	37	chr9	138590901	138590901	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctgggaccctcggccaccGtaggggccttgggcgggccc	17	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:138590901G>A	uc004cgl.2	-	2	198	c.137C>T	c.(136-138)ACG>ATG	p.T46M	SOHLH1_uc010nbe.2_Missense_Mutation_p.T46M	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	46					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CTCGGCCACCGTAGGGGCCTT	0.711													0	0	0	0.004482	0	8	12										A	138590901	G	A	138590901	3	1	46	1	0	0	0	0	1	0	0	0	14923	1145	40	2	1095	2	SOHLH1	9	138590901	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1262550	138590901	2622530	886	12583										
KCNT1	57582	broad.mit.edu	37	chr9	138662868	138662868	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggaggagaagcggaagaaGagggccttctcggggcaggg	20	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:138662868G>A	uc011mdq.1	+	18	2009	c.1935G>A	c.(1933-1935)AAG>AAA	p.K645K	KCNT1_uc011mdr.1_Silent_p.K472K|KCNT1_uc010nbf.2_Silent_p.K600K|KCNT1_uc004cgo.1_Silent_p.K394K	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	645						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AGCGGAAGAAGAGGGCCTTCT	0.652													0	0	0	0.013537	0	13	5										A	138662868	G	A	138662868	2	1	46	1	0	0	0	0	0	0	0	1	8091	933	33	1		1	KCNT1	9	138662868	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	71967	138662868	2550563	887	12584										
CAMSAP1	157922	broad.mit.edu	37	chr9	138713633	138713633	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctctctgctcctccttcacGagaaagtcttcggttttgga	8	12	4	1	rs138126670		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:138713633G>A	uc004cgr.3	-	11	2874	c.2874C>T	c.(2872-2874)CTC>CTT	p.L958L	CAMSAP1_uc004cgq.3_Silent_p.L848L|CAMSAP1_uc010nbg.2_Silent_p.L680L	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	958						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CCTCCTTCACGAGAAAGTCTT	0.562													0	0	0	0.01441	0	115	41										A	138713633	G	A	138713633	2	1	46	1	0	0	0	0	0	0	0	1	2611	1045	37	1		1	CAMSAP1	9	138713633	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	50765	138713633	2499798	888	12585										
MAMDC4	158056	broad.mit.edu	37	chr9	139748504	139748504	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgtggctctagatgacctaGagttctgggactgtggtctg	14	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:139748504G>A	uc004cjs.2	+	6	696	c.646G>A	c.(646-648)GAG>AAG	p.E216K	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	216	Extracellular (Potential).|MAM 1.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		AGATGACCTAGAGTTCTGGGA	0.627													0	0	0	0.007413	0	16	71										A	139748504	G	A	139748504	3	1	46	1	0	0	0	0	1	0	0	0	9204	943	33	1	668	1	MAMDC4	9	139748504	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1034871	139748504	1464927	889	12586										
ABCA2	20	broad.mit.edu	37	chr9	139907259	139907259	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgcctgtgaccacccgcatCtggggcgggtgcccgcccac	13	18	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:139907259C>T	uc011mem.1	-	30	5131	c.4983G>A	c.(4981-4983)CAG>CAA	p.Q1661Q	ABCA2_uc011mel.1_Silent_p.Q1662Q|ABCA2_uc004ckl.1_Silent_p.Q1592Q|ABCA2_uc004ckm.1_Silent_p.Q1692Q|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1661					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCACCCGCATCTGGGGCGGGT	0.687													0	0	0	0.010729	0	8	8										T	139907259	C	T	139907259	2	4	46	1	0	0	0	0	0	0	0	1	32	912	32	1		1	ABCA2	9	139907259	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	158755	139907259	1306172	890	12587										
SSNA1	8636	broad.mit.edu	37	chr9	140083657	140083657	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacgagaacctggcacgcaaGattgcctctcgcaacgagtt	10	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:140083657G>A	uc004cls.2	+	2	317	c.192G>A	c.(190-192)AAG>AAA	p.K64K	ANAPC2_uc004clq.1_5'Flank|ANAPC2_uc004clr.1_5'Flank|ANAPC2_uc011mer.1_5'Flank	NM_003731	NP_003722	O43805	SSNA1_HUMAN	nuclear autoantigen of 14 kDa	64	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus				breast(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.43e-05)|Epithelial(140;0.00087)		TGGCACGCAAGATTGCCTCTC	0.642													0	0	0	0.000602	0	4	25										A	140083657	G	A	140083657	2	1	46	1	0	0	0	0	0	0	0	1	15186	933	33	1		1	SSNA1	9	140083657	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	176398	140083657	1129774	891	12588										
NRARP	441478	broad.mit.edu	37	chr9	140196323	140196323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgcccttgcgcacagcctCctggaagatgcgctgcgtct	12	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:140196323C>T	uc004cmo.2	-	1	381	c.58G>A	c.(58-60)GAG>AAG	p.E20K	C9orf167_uc011mew.1_Intron	NM_001004354	NP_001004354	Q7Z6K4	NRARP_HUMAN	NOTCH-regulated ankyrin repeat protein	20					negative regulation of Notch signaling pathway|positive regulation of canonical Wnt receptor signaling pathway						0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.185)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000273)		CGCACAGCCTCCTGGAAGATG	0.517													0	0	0	0.001168	0	6	40										T	140196323	C	T	140196323	3	4	46	1	0	0	0	0	1	0	0	0	10639	864	30	1	290	1	NRARP	9	140196323	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	112666	140196323	1017108	892	12589										
MRPL41	64975	broad.mit.edu	37	chr9	140446923	140446923	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagggaaagctcttccagctCtaccccaggaacttcctgcg	10	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:140446923C>T	uc004cnh.3	+	2	520	c.390C>T	c.(388-390)CTC>CTT	p.L130L	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	130					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		TCTTCCAGCTCTACCCCAGGA	0.557													0	0	0	0.014323	0	23	16										T	140446923	C	T	140446923	2	4	46	1	0	0	0	0	0	0	0	1	9805	900	32	1		1	MRPL41	9	140446923	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	250600	140446923	766508	893	12590										
AKR1E2	83592	broad.mit.edu	37	chr10	4875593	4875593	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaaacagcatgcagaaagAgtctcaaggccttgaagctg	12	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:4875593A>G	uc001ihi.2	+	3	374	c.259A>G	c.(259-261)AGT>GGT	p.S87G	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Intron|AKR1E2_uc001ihh.1_Missense_Mutation_p.S87G|AKR1E2_uc009xhw.2_Missense_Mutation_p.S87G|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Missense_Mutation_p.S87G	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	87						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						ATGCAGAAAGAGTCTCAAGGC	0.527													0	0	0	0.006214	0	9	425										G	4875593	A	G	4875593	3	3	46	1	0	0	0	0	1	0	0	0	474	304	11	5	269	5	AKR1E2	10	4875593	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08		4875593	130659154	894	12591										
AKR1C1	1645	broad.mit.edu	37	chr10	5009208	5009208	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttggattatgttgacctctaCcttattcattttccagtgtc	6	9	2	1	rs138894545	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:5009208C>T	uc001iho.2	+	8	1183	c.342C>T	c.(340-342)TAC>TAT	p.Y114Y	AKR1E2_uc001ihl.1_Intron|AKR1C2_uc010qan.1_Intron|AKR1C3_uc001ihr.2_Intron|AKR1C1_uc009xhx.2_Silent_p.Y114Y|AKR1C1_uc001ihq.2_Silent_p.Y114Y	NM_001353	NP_001344	Q04828	AK1C1_HUMAN	aldo-keto reductase family 1, member C1	114					bile acid and bile salt transport|bile acid metabolic process|cholesterol homeostasis|intestinal cholesterol absorption|protein homooligomerization|response to organophosphorus|xenobiotic metabolic process	cytosol	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid binding|indanol dehydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			ovary(2)	2					NADH(DB00157)	TTGACCTCTACCTTATTCATT	0.383													0	0	0	0.012319	0	5	191										T	5009208	C	T	5009208	2	4	46	1	0	0	0	0	0	0	0	1	469	518	18	2		2	AKR1C1	10	5009208	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	133615	5009208	130525539	895	12592										
FRMD4A	55691	broad.mit.edu	37	chr10	13708121	13708121	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatgatcagcgaagccctctGggtgggtttcttcccagact	11	11	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:13708121G>A	uc001ims.2	-	18	1931	c.1579C>T	c.(1579-1581)CAG>TAG	p.Q527*	FRMD4A_uc009xjf.1_Nonsense_Mutation_p.Q527*|FRMD4A_uc001imt.1_Nonsense_Mutation_p.Q560*	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	527						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GAAGCCCTCTGGGTGGGTTTC	0.567													0	0	0	0.01441	0	116	109										A	13708121	G	A	13708121	4	1	46	1	0	0	0	0	0	1	0	0	6051	1357	47	2	1568	2	FRMD4A	10	13708121	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8698913	13708121	121826626	896	12593										
PTPLA	9200	broad.mit.edu	37	chr10	17641359	17641359	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaaggaatagcgagtgatctCtgtcacagtccacgcgacca	11	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:17641359C>T	uc001ipg.2	-	5	570	c.535G>A	c.(535-537)GAG>AAG	p.E179K		NM_014241	NP_055056	B0YJ81	HACD1_HUMAN	protein tyrosine phosphatase-like, member A	179	Helical; (Potential).				fatty acid biosynthetic process|multicellular organismal development|signal transduction	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein tyrosine phosphatase activity			central_nervous_system(1)|skin(1)	2						CGAGTGATCTCTGTCACAGTC	0.443													0	0	0	0.007413	0	17	31										T	17641359	C	T	17641359	3	4	46	1	0	0	0	0	1	0	0	0	12774	922	32	1	343	1	PTPLA	10	17641359	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3933238	17641359	117893388	897	12594										
PLXDC2	84898	broad.mit.edu	37	chr10	20436813	20436813	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgctcatggatggacgaatCatctttggatacaaagaagt	10	7	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:20436813C>T	uc001iqg.1	+	6	1402	c.765C>T	c.(763-765)ATC>ATT	p.I255I	PLXDC2_uc001iqh.1_Silent_p.I206I|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	255	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						ATGGACGAATCATCTTTGGAT	0.453													0	0	0	0.014323	0	21	48										T	20436813	C	T	20436813	2	4	46	1	0	0	0	0	0	0	0	1	12118	816	29	1		1	PLXDC2	10	20436813	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2795454	20436813	115097934	898	12595										
C10orf114	399726	broad.mit.edu	37	chr10	21785724	21785724	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctccgccgtgcgccaccctGagggctcccgcgattgcatc	11	18	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:21785724G>A	uc001iqn.3	-	1	490	c.20C>T	c.(19-21)TCA>TTA	p.S7L	MIR1915_hsa-mir-1915|MI0008336_5'Flank	NM_001010911	NP_001010911	Q5T4H9	CJ114_HUMAN	hypothetical protein LOC399726	7											0						GCGCCACCCTGAGGGCTCCCG	0.647													0	0	0	0.000602	0	3	9										A	21785724	G	A	21785724	3	1	46	1	0	0	0	0	1	0	0	0	1585	1294	45	1	398	1	C10orf114	10	21785724	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1348911	21785724	113749023	899	12596										
C10orf140	387640	broad.mit.edu	37	chr10	21804624	21804624	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accctttgtatcattgcactCgcactttagcttatttgtaa	5	10	1	0	rs35145063		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:21804624C>T	uc009xkd.2	-	4	4381	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	629						nucleus	nucleotide binding			ovary(1)	1						TCATTGCACTCGCACTTTAGC	0.393													0	0	0	0.01441	0	162	174										T	21804624	C	T	21804624	3	4	46	1	0	0	0	0	1	0	0	0	1595	893	31	1	602	1	C10orf140	10	21804624	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	18900	21804624	113730123	900	12597										
KIAA1217	56243	broad.mit.edu	37	chr10	24832553	24832553	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcattttcgatgagcccatgGacatccggtctgcctataag	9	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:24832553G>A	uc001iru.3	+	19	4757	c.4354G>A	c.(4354-4356)GAC>AAC	p.D1452N	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Missense_Mutation_p.D1135N|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Missense_Mutation_p.D288N	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1452					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TGAGCCCATGGACATCCGGTC	0.393													0	0	0	0.013114	0	44	46										A	24832553	G	A	24832553	3	1	46	1	0	0	0	0	1	0	0	0	8216	1174	41	1	4428	1	KIAA1217	10	24832553	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3027929	24832553	110702194	901	12598										
ACBD5	91452	broad.mit.edu	37	chr10	27524079	27524079	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaaagtttacagggtccttCagttgcctgcttatagaagc	10	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:27524079C>T	uc010qdp.1	-	3	435	c.244G>A	c.(244-246)GAA>AAA	p.E82K	ACBD5_uc010qdm.1_Missense_Mutation_p.E80K|ACBD5_uc010qdn.1_Intron|ACBD5_uc010qdo.1_Intron|ACBD5_uc001ito.2_Missense_Mutation_p.E47K|ACBD5_uc001itp.2_Intron|ACBD5_uc001itq.2_Intron|ACBD5_uc001itr.1_Intron	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	80	ACB.				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						CAGGGTCCTTCAGTTGCCTGC	0.343													0	0	0	0.012319	0	23	58										T	27524079	C	T	27524079	3	4	46	1	0	0	0	0	1	0	0	0	125	835	29	1	1377	1	ACBD5	10	27524079	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2691526	27524079	108010668	902	12599										
SVIL	6840	broad.mit.edu	37	chr10	29811369	29811369	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagacatggttttgctgggtGagtcaagaaggccctcccct	12	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:29811369G>A	uc001iut.1	-	16	4112	c.3359C>T	c.(3358-3360)TCA>TTA	p.S1120L	SVIL_uc010qdw.1_Missense_Mutation_p.S18L|SVIL_uc001iuu.1_Missense_Mutation_p.S694L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1120					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TTTGCTGGGTGAGTCAAGAAG	0.468													0	0	0	0.013726	0	32	30										A	29811369	G	A	29811369	3	1	46	1	0	0	0	0	1	0	0	0	15418	1294	45	1	3377	1	SVIL	10	29811369	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2287290	29811369	105723378	903	12600										
GJD4	219770	broad.mit.edu	37	chr10	35894525	35894525	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggacttgctagggtttctCatcatcacattaaactgcaa	8	9	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:35894525C>T	uc001iyy.1	+	1	188	c.30C>T	c.(28-30)CTC>CTT	p.L10L		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	10	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TAGGGTTTCTCATCATCACAT	0.517													0	0	0	0.001855	0	12	34										T	35894525	C	T	35894525	2	4	46	1	0	0	0	0	0	0	0	1	6419	813	29	1		1	GJD4	10	35894525	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6083156	35894525	99640222	904	12601										
ANKRD30A	91074	broad.mit.edu	37	chr10	37508401	37508401	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtgctccatcaaccactttCtgaagctcaaaggaaatcca	7	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:37508401C>T	uc001iza.1	+	34	3692	c.3593C>T	c.(3592-3594)TCT>TTT	p.S1198F		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAACCACTTTCTGAAGCTCAA	0.373													0	0	0	0.01441	0	55	43										T	37508401	C	T	37508401	3	4	46	1	0	0	0	0	1	0	0	0	658	913	32	1	3727	1	ANKRD30A	10	37508401	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1613876	37508401	98026346	905	12602										
BMS1	9790	broad.mit.edu	37	chr10	43292488	43292488	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaatctgaagaaagctcctCactcagtgcagaggaagaag	11	8	3	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:43292488C>T	uc001jaj.2	+	10	2154	c.1796C>T	c.(1795-1797)TCA>TTA	p.S599L		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	599					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAAAGCTCCTCACTCAGTGCA	0.458													0	0	0	0.01441	0	86	80										T	43292488	C	T	43292488	3	4	46	1	0	0	0	0	1	0	0	0	1472	838	29	1	1830	1	BMS1	10	43292488	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5784087	43292488	92242259	906	12603										
RET	5979	broad.mit.edu	37	chr10	43612094	43612094	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaaaaactctaggagaaggCgaatttggaaaagtggtcaa	13	4	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:43612094C>T	uc001jal.2	+	12	2389	c.2199C>T	c.(2197-2199)GGC>GGT	p.G733G	RET_uc001jak.1_Silent_p.G733G|RET_uc010qez.1_Silent_p.G479G	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	733	Protein kinase.|ATP (By similarity).|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TAGGAGAAGGCGAATTTGGAA	0.527		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	0.01441	0	41	256										T	43612094	C	T	43612094	2	4	46	1	0	0	0	0	0	0	0	1	13235	755	27	2		2	RET	10	43612094	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	319606	43612094	91922653	907	12604										
CSGALNACT2	55454	broad.mit.edu	37	chr10	43651198	43651198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgatgaagatgatgaacaaGaagatgaggagggtcccctt	13	6	0	8			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:43651198G>A	uc001jan.2	+	2	936	c.601G>A	c.(601-603)GAA>AAA	p.E201K	CSGALNACT2_uc001jam.1_Missense_Mutation_p.E201K	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	201	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						TGATGAACAAGAAGATGAGGA	0.363													0	0	0	0.005524	0	37	90										A	43651198	G	A	43651198	3	1	46	1	0	0	0	0	1	0	0	0	3939	943	33	1	603	1	CSGALNACT2	10	43651198	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	39104	43651198	91883549	908	12605										
TMEM72	643236	broad.mit.edu	37	chr10	45430175	45430175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaagaggaaagctgcccccGaggtgctggcctccccagag	14	13	0	3	rs140679942	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:45430175G>A	uc001jbn.2	+	5	618	c.421G>A	c.(421-423)GAG>AAG	p.E141K	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.E23K	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	141						integral to membrane					0						AGCTGCCCCCGAGGTGCTGGC	0.602													0	0	0	0.005524	0	33	194										A	45430175	G	A	45430175	3	1	46	1	0	0	0	0	1	0	0	0	16198	1059	37	1	439	1	TMEM72	10	45430175	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1778977	45430175	90104572	909	12606										
SYT15	83849	broad.mit.edu	37	chr10	46963894	46963894	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggctagcggtatccagctCggtggcatcggccttgaagc	15	11	0	1	rs2484844		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:46963894C>T	uc001jea.2	-	7	1222	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	SYT15_uc001jdz.2_Missense_Mutation_p.E357K|SYT15_uc001jeb.2_Missense_Mutation_p.E235K|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	357	Cytoplasmic (Potential).|C2 2.					integral to membrane|plasma membrane					0						GTATCCAGCTCGGTGGCATCG	0.567													0	0	0	0.000602	0	5	96										T	46963894	C	T	46963894	3	4	46	1	0	0	0	0	1	0	0	0	15468	893	31	1	258	1	SYT15	10	46963894	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1533719	46963894	88570853	910	12607										
GDF2	2658	broad.mit.edu	37	chr10	48416478	48416478	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcctgcgaagggaccccactCaggttaaggctgcgcaggaa	13	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:48416478C>G	uc001jfa.1	-	1	379	c.216G>C	c.(214-216)CTG>CTC	p.L72L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	72					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GGACCCCACTCAGGTTAAGGC	0.577													0	0	0	0.008871	0	18	65										G	48416478	C	G	48416478	2	3	46	1	0	0	0	0	0	0	0	1	6314	813	29	1		1	GDF2	10	48416478	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1452584	48416478	87118269	911	12608										
GDF2	2658	broad.mit.edu	37	chr10	48416501	48416501	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttaaggctgcgcaggaaatCcaccttcacgttctccagaa	9	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:48416501C>G	uc001jfa.1	-	1	356	c.193G>C	c.(193-195)GAT>CAT	p.D65H		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	65					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						CGCAGGAAATCCACCTTCACG	0.587													0	0	0	0.006122	0	18	67										G	48416501	C	G	48416501	3	3	46	1	0	0	0	0	1	0	0	0	6314	855	30	1	1104	1	GDF2	10	48416501	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	23	48416501	87118246	912	12609										
DKK1	22943	broad.mit.edu	37	chr10	54076536	54076536	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcaccatcaagccagtaattCttctaggcttcacacttgtc	5	13	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:54076536C>T	uc001jjr.2	+	4	924	c.770C>T	c.(769-771)TCT>TTT	p.S257F	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	257	DKK-type Cys-2.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						GCCAGTAATTCTTCTAGGCTT	0.403													0	0	0	0.01441	0	59	39										T	54076536	C	T	54076536	3	4	46	1	0	0	0	0	1	0	0	0	4544	913	32	1	784	1	DKK1	10	54076536	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5660035	54076536	81458211	913	12610										
ARID5B	84159	broad.mit.edu	37	chr10	63700148	63700148	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcaacttcaaagacgttctCaaggagaaggcagacctggg	11	10	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:63700148C>T	uc001jlt.1	+	3	509	c.483C>T	c.(481-483)CTC>CTT	p.L161L	ARID5B_uc010qil.1_Silent_p.L161L	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	161					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					AAGACGTTCTCAAGGAGAAGG	0.418													0	0	0	0.007413	0	18	15										T	63700148	C	T	63700148	2	4	46	1	0	0	0	0	0	0	0	1	922	813	29	1		1	ARID5B	10	63700148	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9623612	63700148	71834599	914	12611										
JMJD1C	221037	broad.mit.edu	37	chr10	64967741	64967741	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcaccggagttaaagttgGaggggaaagactactatagc	12	7	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:64967741G>T	uc001jmn.2	-	10	3988	c.3688C>A	c.(3688-3690)CCA>ACA	p.P1230T	JMJD1C_uc001jml.2_Missense_Mutation_p.P1011T|JMJD1C_uc001jmm.2_Missense_Mutation_p.P942T|JMJD1C_uc010qiq.1_Missense_Mutation_p.P1048T|JMJD1C_uc009xpi.2_Missense_Mutation_p.P1048T|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.P267T	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1230					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GTTAAAGTTGGAGGGGAAAGA	0.468													1	0	4.87955e-14	0.005443	5.11775e-14	27	102										T	64967741	G	T	64967741	3	4	46	1	0	0	0	0	1	0	0	0	7950	1174	41	3	4002	3	JMJD1C	10	64967741	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1267593	64967741	70567006	915	12612										
JMJD1C	221037	broad.mit.edu	37	chr10	64974489	64974489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atccatattgcattcctgagGaagtaaatcattagaattat	6	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:64974489G>A	uc001jmn.2	-	8	1738	c.1438C>T	c.(1438-1440)CCT>TCT	p.P480S	JMJD1C_uc001jml.2_Missense_Mutation_p.P261S|JMJD1C_uc001jmm.2_Missense_Mutation_p.P192S|JMJD1C_uc010qiq.1_Missense_Mutation_p.P298S|JMJD1C_uc009xpi.2_Missense_Mutation_p.P298S|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.P192S	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	480					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CATTCCTGAGGAAGTAAATCA	0.373													0	0	0	0.01441	0	61	190										A	64974489	G	A	64974489	3	1	46	1	0	0	0	0	1	0	0	0	7950	1174	41	1	6260	1	JMJD1C	10	64974489	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6748	64974489	70560258	916	12613										
HERC4	26091	broad.mit.edu	37	chr10	69748513	69748513	+	Frame_Shift_Del	DEL	C	C	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataccgatcttgtagagtttCaaaagatgtaccacaacttc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:69748513delC	uc001jng.3	-	15	2024	c.1713delG	c.(1711-1713)TTGfs	p.L571fs	HERC4_uc009xpq.2_Frame_Shift_Del_p.L112fs|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Frame_Shift_Del_p.L571fs|HERC4_uc009xpr.2_Frame_Shift_Del_p.L571fs|HERC4_uc001jni.3_Frame_Shift_Del_p.L315fs|HERC4_uc001jnj.2_Frame_Shift_Del_p.L571fs	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	571					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						TGTAGAGTTTCAAAAGATGTA	0.343																		57	176	---	---								-	69748513	C	-	69748513	7	5	46	1	0	1	0	1	0	0	0	0	7060	825	29	0	1508	0	HERC4	10	69748513	Frame_Shift_Del	DEL	C	TCGA-DK-A1AC-01A-11D-A13W-08	4774024	69748513	65786234	917	12614										
NEUROG3	50674	broad.mit.edu	37	chr10	71332454	71332454	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatcttggtgagcttcgcgtCgtctgggaaggtgggcagga	18	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:71332454C>T	uc001jpp.2	-	2	504	c.346G>A	c.(346-348)GAC>AAC	p.D116N		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	116	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						AGCTTCGCGTCGTCTGGGAAG	0.622													0	0	0	0.001984	0	7	21										T	71332454	C	T	71332454	3	4	46	1	0	0	0	0	1	0	0	0	10354	884	31	1	302	1	NEUROG3	10	71332454	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1583941	71332454	64202293	918	12615										
TYSND1	219743	broad.mit.edu	37	chr10	71902546	71902546	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacagccgaaaggatgcctGaggtcaccgagggcccgcaa	13	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:71902546G>A	uc001jqr.2	-	3	1515	c.1361C>T	c.(1360-1362)TCA>TTA	p.S454L	TYSND1_uc001jqq.2_RNA|TYSND1_uc001jqs.2_Intron|TYSND1_uc001jqt.2_Intron	NM_173555	NP_775826	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1 isoform a	454	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			large_intestine(1)	1						AAGGATGCCTGAGGTCACCGA	0.642													0	0	0	0.001168	0	6	20										A	71902546	G	A	71902546	3	1	46	1	0	0	0	0	1	0	0	0	16814	1294	45	1	347	1	TYSND1	10	71902546	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	570092	71902546	63632201	919	12616										
SLC29A3	55315	broad.mit.edu	37	chr10	73082533	73082533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggccgttgtctcagaggacGactttcagcacagttcaaac	10	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:73082533G>A	uc001jrr.3	+	2	79	c.22G>A	c.(22-24)GAC>AAC	p.D8N	SLC29A3_uc001jrs.3_Missense_Mutation_p.D8N|SLC29A3_uc010qjq.1_5'UTR|SLC29A3_uc001jrt.3_5'UTR|SLC29A3_uc001jru.3_5'UTR	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	8	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CTCAGAGGACGACTTTCAGCA	0.597													0	0	0	0.00278	0	22	85										A	73082533	G	A	73082533	3	1	46	1	0	0	0	0	1	0	0	0	14536	1058	37	1	28	1	SLC29A3	10	73082533	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1179987	73082533	62452214	920	12617										
NDST2	8509	broad.mit.edu	37	chr10	75567514	75567514	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctaggcggctggggcgtgtGagatgcagtagcggggcaga	20	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:75567514G>C	uc001jvk.2	-	3	1437	c.633C>G	c.(631-633)CTC>CTG	p.L211L	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Silent_p.L88L|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Silent_p.L88L	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	211	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					TGGGGCGTGTGAGATGCAGTA	0.552													0	0	0	0.004482	0	9	42										C	75567514	G	C	75567514	2	2	46	1	0	0	0	0	0	0	0	1	10256	1277	45	1		1	NDST2	10	75567514	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2484981	75567514	59967233	921	12618										
ADK	132	broad.mit.edu	37	chr10	75960592	75960592	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagtggacaaagatttccttGataagtaagtattaaactct	7	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:75960592G>A	uc001jwi.2	+	2	208	c.136G>A	c.(136-138)GAT>AAT	p.D46N	ADK_uc010qlb.1_Missense_Mutation_p.D46N|ADK_uc001jwj.2_Missense_Mutation_p.D29N|ADK_uc010qlc.1_Missense_Mutation_p.D29N	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	46					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	AGATTTCCTTGATAAGTAAGT	0.328													0	0	0	0.001855	0	13	42										A	75960592	G	A	75960592	3	1	46	1	0	0	0	0	1	0	0	0	320	1290	45	1	160	1	ADK	10	75960592	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	393078	75960592	59574155	922	12619										
WAPAL	23063	broad.mit.edu	37	chr10	88260375	88260375	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaactgggagttccaagtatCatttgtttccttgatttcag	8	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:88260375C>T	uc001kdo.2	-	3	1067	c.625G>A	c.(625-627)GAT>AAT	p.D209N	WAPAL_uc001kdn.2_Missense_Mutation_p.D252N|WAPAL_uc009xsw.2_Missense_Mutation_p.D209N	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	209	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTCCAAGTATCATTTGTTTCC	0.378													0	0	0	0.007835	0	41	138										T	88260375	C	T	88260375	3	4	46	1	0	0	0	0	1	0	0	0	17245	826	29	1	3015	1	WAPAL	10	88260375	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	12299783	88260375	47274372	923	12620										
LDB3	11155	broad.mit.edu	37	chr10	88439133	88439133	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatccaatcagatcacaccaGgcagcaaggcagcccagtcc	8	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:88439133G>A	uc001kdv.2	+	2	126	c.103G>A	c.(103-105)GGC>AGC	p.G35S	LDB3_uc010qml.1_Missense_Mutation_p.G35S|LDB3_uc010qmm.1_Missense_Mutation_p.G35S|LDB3_uc001kdu.2_Missense_Mutation_p.G35S|LDB3_uc009xsz.2_5'UTR|LDB3_uc001kdr.2_Missense_Mutation_p.G35S|LDB3_uc009xsy.2_Missense_Mutation_p.G35S|LDB3_uc001kds.2_Missense_Mutation_p.G35S|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	35	PDZ.					cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						GATCACACCAGGCAGCAAGGC	0.587													0	0	0	0.005443	0	26	27										A	88439133	G	A	88439133	3	1	46	1	0	0	0	0	1	0	0	0	8697	1000	35	2	109	2	LDB3	10	88439133	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	178758	88439133	47095614	924	12621										
MMRN2	79812	broad.mit.edu	37	chr10	88696506	88696506	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attggggctggggttcaggtCttaaacatcaggaagccccc	13	10	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:88696506C>T	uc001kea.2	-	7	2971	c.2844G>A	c.(2842-2844)AAG>AAA	p.K948K	MMRN2_uc010qmn.1_Silent_p.K591K	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	948	C1q.					extracellular space				large_intestine(1)	1						GGGTTCAGGTCTTAAACATCA	0.552													0	0	0	0.01441	0	87	65										T	88696506	C	T	88696506	2	4	46	1	0	0	0	0	0	0	0	1	9671	912	32	1		1	MMRN2	10	88696506	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	257373	88696506	46838241	925	12622										
HTR7	3363	broad.mit.edu	37	chr10	92617043	92617043	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatgaccgccacagccaccGagaggtcggccagcgccagg	14	16	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:92617043G>C	uc001kha.2	-	1	629	c.386C>G	c.(385-387)TCG>TGG	p.S129W	HTR7_uc001kgz.2_Missense_Mutation_p.S129W|HTR7_uc001khb.2_Missense_Mutation_p.S129W	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	129	Helical; Name=2; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CACAGCCACCGAGAGGTCGGC	0.597													0	0	0	0.008291	0	10	48										C	92617043	G	C	92617043	3	2	46	1	0	0	0	0	1	0	0	0	7452	1059	37	1	1073	1	HTR7	10	92617043	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3920537	92617043	42917704	926	12623										
PDE6C	5146	broad.mit.edu	37	chr10	95400233	95400233	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagatggatgtacactgtGaggaaagggtaccgagctgt	14	7	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:95400233G>C	uc001kiu.3	+	13	1794	c.1656G>C	c.(1654-1656)GTG>GTC	p.V552V		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	552					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TGTACACTGTGAGGAAAGGGT	0.448													0	0	0	0.00874	0	40	113										C	95400233	G	C	95400233	2	2	46	1	0	0	0	0	0	0	0	1	11647	1277	45	1		1	PDE6C	10	95400233	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2783190	95400233	40134514	927	12624										
CYP2C9	1559	broad.mit.edu	37	chr10	96698472	96698472	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggtccttgtgctctgtctCtcatgtttgcttctcctttc	8	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:96698472C>G	uc001kka.3	+	1	58	c.33C>G	c.(31-33)CTC>CTG	p.L11L	CYP2C9_uc009xut.2_Silent_p.L11L|CYP2C9_uc001kjz.2_Silent_p.L11L	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	11					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGCTCTGTCTCTCATGTTTGC	0.478													0	0	0	0.01441	0	171	160										G	96698472	C	G	96698472	2	3	46	1	0	0	0	0	0	0	0	1	4168	900	32	1		1	CYP2C9	10	96698472	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1298239	96698472	38836275	928	12625										
ENTPD1	953	broad.mit.edu	37	chr10	97607265	97607265	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggatataagaaggtagtgaaCgtaagtgacctttacaagac	11	5	0	4	rs149509898	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:97607265C>T	uc001klh.3	+	7	1200	c.876C>T	c.(874-876)AAC>AAT	p.N292N	ENTPD1_uc001kli.3_Silent_p.N299N|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Silent_p.N304N|ENTPD1_uc010qok.1_Silent_p.N184N|ENTPD1_uc010qol.1_Silent_p.N184N|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Silent_p.N154N|ENTPD1_uc009xva.2_Silent_p.N154N|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	292	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGGTAGTGAACGTAAGTGACC	0.418													0	0	0	0.003271	0	35	100										T	97607265	C	T	97607265	2	4	46	1	0	0	0	0	0	0	0	1	5138	535	19	2		2	ENTPD1	10	97607265	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	908793	97607265	37927482	929	12626										
BLNK	29760	broad.mit.edu	37	chr10	97964290	97964290	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaggaaaggattcttacttCtgggcaggaggaaacactgg	13	6	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:97964290C>T	uc001kls.3	-	12	1078	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q	BLNK_uc001kme.3_Silent_p.Q195Q|BLNK_uc001klt.3_Silent_p.Q191Q|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Silent_p.Q218Q|BLNK_uc001klv.3_Silent_p.Q195Q|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Silent_p.Q277Q|BLNK_uc001kly.3_Silent_p.Q300Q|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Silent_p.Q277Q|BLNK_uc001kmb.3_Silent_p.Q96Q|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Silent_p.Q218Q|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	300					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATTCTTACTTCTGGGCAGGAG	0.448													0	0	0	0.01441	0	46	69										T	97964290	C	T	97964290	2	4	46	1	0	0	0	0	0	0	0	1	1447	912	32	1		1	BLNK	10	97964290	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	357025	97964290	37570457	930	12627										
TLL2	7093	broad.mit.edu	37	chr10	98144396	98144396	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagacggtgttgtcggacttGaactccacgcgcatgttgtt	13	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:98144396G>A	uc001kml.1	-	16	2368	c.2142C>T	c.(2140-2142)TTC>TTT	p.F714F		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	714	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TGTCGGACTTGAACTCCACGC	0.637													0	0	0	0.009535	0	29	83										A	98144396	G	A	98144396	2	1	46	1	0	0	0	0	0	0	0	1	15943	1281	45	1		1	TLL2	10	98144396	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	180106	98144396	37390351	931	12628										
TM9SF3	56889	broad.mit.edu	37	chr10	98336574	98336574	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catccataagacaacttcctCtttatcttgatactgaaaca	3	11	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:98336574C>G	uc001kmm.3	-	2	332	c.115G>C	c.(115-117)GAG>CAG	p.E39Q	TM9SF3_uc010qot.1_Missense_Mutation_p.E39Q	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	39						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		ACAACTTCCTCTTTATCTTGA	0.313													0	0	0	0.00333	0	24	62										G	98336574	C	G	98336574	3	3	46	1	0	0	0	0	1	0	0	0	15976	922	32	1	1710	1	TM9SF3	10	98336574	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	192178	98336574	37198173	932	12629										
LOXL4	84171	broad.mit.edu	37	chr10	100022549	100022549	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccaggtcaaggcagcttcGaagcccagctggcggcaagc	14	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:100022549G>A	uc001kpa.1	-	2	379	c.228C>T	c.(226-228)TTC>TTT	p.F76F		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	76	SRCR 1.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		AGGCAGCTTCGAAGCCCAGCT	0.622											OREG0020428	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	31	27										A	100022549	G	A	100022549	2	1	46	1	0	0	0	0	0	0	0	1	8902	1049	37	1		1	LOXL4	10	100022549	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1685975	100022549	35512198	933	12630										
CUTC	51076	broad.mit.edu	37	chr10	101514304	101514304	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaggtggtataacagacaGaaatctacaaaggatccttg	11	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101514304G>T	uc001kqd.3	+	8	768	c.620G>T	c.(619-621)AGA>ATA	p.R207I	CUTC_uc001kqe.3_RNA	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	207					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		ATAACAGACAGAAATCTACAA	0.363													1	0	2.80266e-47	0.01441	2.98126e-47	81	221										T	101514304	G	T	101514304	3	4	46	1	0	0	0	0	1	0	0	0	4063	942	33	3	650	3	CUTC	10	101514304	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1491755	101514304	34020443	934	12631										
ABCC2	1244	broad.mit.edu	37	chr10	101594192	101594192	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttgcgcagctggattacatGcttcctggggataatcagca	11	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101594192G>A	uc001kqf.2	+	24	3453	c.3314G>A	c.(3313-3315)TGC>TAC	p.C1105Y		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1105	ABC transmembrane type-1 2.|Helical; Name=14; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGGATTACATGCTTCCTGGGG	0.473													0	0	0	0.01441	0	87	96										A	101594192	G	A	101594192	3	1	46	1	0	0	0	0	1	0	0	0	53	1319	46	2	3408	2	ABCC2	10	101594192	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	79888	101594192	33940555	935	12632										
CHUK	1147	broad.mit.edu	37	chr10	101953863	101953865	+	In_Frame_Del	DEL	TCT	TCT	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttagggagtagatcaataaTcttctgcttacagcccaaca							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101953863_101953865delTCT	uc001kqp.2	-	18	1905_1907	c.1850_1852delAGA	c.(1849-1854)AAGATT>ATT	p.K617del		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	617					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AGATCAATAATCTTCTGCTTACA	0.433																		41	44	---	---								-	101953865	TCT	-	101953863	7	5	46	1	0	1	0	1	0	0	0	0	3416	1435	50	0	401	0	CHUK	10	101953863	In_Frame_Del	DEL	TCT	TCGA-DK-A1AC-01A-11D-A13W-08	359671	101953863	33580884	936	12633										
CHUK	1147	broad.mit.edu	37	chr10	101959727	101959727	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgtggtagaagtgtcttaCctgaaggtctgtgttttaac	11	6	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101959727C>T	uc001kqp.2	-	16	1784	c.1729_splice	c.e16+1	p.D577_splice		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AAGTGTCTTACCTGAAGGTCT	0.348													0	0	0	0.014323	0	24	96										T	101959727	C	T	101959727	5	4	46	1	0	0	0	0	0	0	1	0	3416	521	18	2	531	2	CHUK	10	101959727	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5864	101959727	33575020	937	12634										
MRPL43	84545	broad.mit.edu	37	chr10	102746534	102746534	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggcaggatcctgaacctctCgggggcgtagcccgcggaac	16	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:102746534C>T	uc001kry.1	-	3	509	c.437G>A	c.(436-438)CGA>CAA	p.R146Q	MRPL43_uc010qpu.1_Missense_Mutation_p.R146Q|MRPL43_uc001krz.1_Intron|MRPL43_uc001ksa.1_Missense_Mutation_p.R146Q|MRPL43_uc001ksb.1_Missense_Mutation_p.R146Q|MRPL43_uc001ksd.1_Missense_Mutation_p.R146Q|MRPL43_uc001ksc.2_Missense_Mutation_p.R146Q|MRPL43_uc001kse.2_Missense_Mutation_p.R184Q|C10orf2_uc001ksg.2_5'Flank|C10orf2_uc001ksf.2_5'Flank|C10orf2_uc001ksi.2_5'Flank|C10orf2_uc010qpv.1_5'Flank|C10orf2_uc001ksh.2_5'Flank	NM_176792	NP_789762	Q8N983	RM43_HUMAN	mitochondrial ribosomal protein L43 isoform b	146					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		CTGAACCTCTCGGGGGCGTAG	0.627													0	0	0	0.001855	0	12	39										T	102746534	C	T	102746534	3	4	46	1	0	0	0	0	1	0	0	0	9807	884	31	1	453	1	MRPL43	10	102746534	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	786807	102746534	32788213	938	12635										
KCNIP2	30819	broad.mit.edu	37	chr10	103588903	103588903	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgctcctgcagctgctccaGaccctcaggccggtgacaca	10	16	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:103588903G>A	uc001kub.2	-	4	629	c.277C>T	c.(277-279)CTG>TTG	p.L93L	KCNIP2_uc010qqg.1_5'Flank|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Silent_p.V14V|KCNIP2_uc001ktz.2_Silent_p.L48L|KCNIP2_uc009xwu.2_Silent_p.L43L|KCNIP2_uc009xwv.2_Silent_p.L43L|KCNIP2_uc001kuc.2_Silent_p.L108L|KCNIP2_uc001kue.2_Silent_p.L75L|KCNIP2_uc001kud.2_Silent_p.L43L|KCNIP2_uc001kuf.2_Silent_p.L43L|KCNIP2_uc001kua.2_Silent_p.V14V|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Silent_p.L48L|KCNIP2_uc010qqi.1_Silent_p.L43L	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	93	EF-hand 1; degenerate.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		AGCTGCTCCAGACCCTCAGGC	0.617													0	0	0	0.001168	0	5	22										A	103588903	G	A	103588903	2	1	46	1	0	0	0	0	0	0	0	1	8040	933	33	1		1	KCNIP2	10	103588903	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	842369	103588903	31945844	939	12636										
CNNM2	54805	broad.mit.edu	37	chr10	104679815	104679815	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccccttgcactttgttttCaatgacaccaagttggacgc	7	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:104679815C>T	uc001kwm.2	+	1	1702	c.1578C>T	c.(1576-1578)TTC>TTT	p.F526F	CNNM2_uc001kwn.2_Silent_p.F526F|CNNM2_uc001kwl.2_Silent_p.F526F	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	526	CBS 2.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACTTTGTTTTCAATGACACCA	0.453													0	0	0	0.01441	0	51	122										T	104679815	C	T	104679815	2	4	46	1	0	0	0	0	0	0	0	1	3613	825	29	1		1	CNNM2	10	104679815	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1090912	104679815	30854932	940	12637										
ADD3	120	broad.mit.edu	37	chr10	111881975	111881975	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgtctggtggaggaggtgtGaatatgggttcccatcaaaa	15	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:111881975G>A	uc001kyt.3	+	10	1382	c.1068G>A	c.(1066-1068)GTG>GTA	p.V356V	ADD3_uc001kys.3_Silent_p.V356V|ADD3_uc001kyu.2_Silent_p.V356V|ADD3_uc001kyv.2_Silent_p.V356V|ADD3_uc001kyw.2_Silent_p.V356V|ADD3_uc001kyx.2_5'Flank	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	356						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GAGGAGGTGTGAATATGGGTT	0.448													0	0	0	0.012213	0	30	70										A	111881975	G	A	111881975	2	1	46	1	0	0	0	0	0	0	0	1	306	1277	45	1		1	ADD3	10	111881975	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7202160	111881975	23652772	941	12638										
ACSL5	51703	broad.mit.edu	37	chr10	114186017	114186017	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttatttcctttccatagtCatccttagtaggagtggtgg	9	7	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:114186017C>T	uc001kzs.2	+	19	1880	c.1739C>T	c.(1738-1740)TCA>TTA	p.S580L	ACSL5_uc001kzt.2_Missense_Mutation_p.S580L|ACSL5_uc001kzu.2_Missense_Mutation_p.S636L|ACSL5_uc009xxz.2_Missense_Mutation_p.S580L|ACSL5_uc010qrj.1_Missense_Mutation_p.S362L	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	580	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		TTTCCATAGTCATCCTTAGTA	0.433													0	0	0	0.008361	0	29	81										T	114186017	C	T	114186017	3	4	46	1	0	0	0	0	1	0	0	0	180	840	29	1	1981	1	ACSL5	10	114186017	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2304042	114186017	21348730	942	12639										
NRAP	4892	broad.mit.edu	37	chr10	115402797	115402797	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagatccttcttatactccaCcttggaaatcaaaacaccag	4	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:115402797C>A	uc001laj.2	-	12	1275	c.1111G>T	c.(1111-1113)GTG>TTG	p.V371L	NRAP_uc001lak.2_Intron|NRAP_uc001lal.3_Missense_Mutation_p.V371L	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	371	Nebulin 8.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TTATACTCCACCTTGGAAATC	0.388													1	0	1.66031e-10	0.003954	1.72965e-10	26	85										A	115402797	C	A	115402797	3	1	46	1	0	0	0	0	1	0	0	0	10638	521	18	4	4205	4	NRAP	10	115402797	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1216780	115402797	20131950	943	12640										
DCLRE1A	9937	broad.mit.edu	37	chr10	115609522	115609522	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attgtaaacagatgattcttCaattacctgtttctgtttat	5	6	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:115609522C>T	uc001law.2	-	2	2260	c.1342G>A	c.(1342-1344)GAA>AAA	p.E448K		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	448	Nuclear focus formation.				cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GATGATTCTTCAATTACCTGT	0.388								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.013114	0	47	61										T	115609522	C	T	115609522	3	4	46	1	0	0	0	0	1	0	0	0	4294	835	29	1	1812	1	DCLRE1A	10	115609522	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	206725	115609522	19925225	944	12641										
AFAP1L2	84632	broad.mit.edu	37	chr10	116062228	116062228	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acccagccagtggcccatttCctcggaagacttggcctgga	11	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:116062228C>T	uc001lbn.2	-	12	1601	c.1300G>A	c.(1300-1302)GAA>AAA	p.E434K	AFAP1L2_uc001lbo.2_Missense_Mutation_p.E434K|AFAP1L2_uc010qse.1_Missense_Mutation_p.E487K|AFAP1L2_uc001lbp.2_Missense_Mutation_p.E462K|AFAP1L2_uc001lbr.1_Missense_Mutation_p.E434K|AFAP1L2_uc001lbm.2_5'Flank|AFAP1L2_uc010qsd.1_5'UTR|AFAP1L2_uc001lbq.1_5'Flank	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	434	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TGGCCCATTTCCTCGGAAGAC	0.607													0	0	0	0.005443	0	22	66										T	116062228	C	T	116062228	3	4	46	1	0	0	0	0	1	0	0	0	355	864	30	1	1188	1	AFAP1L2	10	116062228	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	452706	116062228	19472519	945	12642										
FAM160B1	57700	broad.mit.edu	37	chr10	116593033	116593033	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atacaaatattccatcgcatCtggaacagatgttagatata	6	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:116593033C>T	uc001lcb.2	+	3	501	c.166C>T	c.(166-168)CTG>TTG	p.L56L	FAM160B1_uc001lcc.2_Silent_p.L56L	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	56										lung(1)	1						TCCATCGCATCTGGAACAGAT	0.353													0	0	0	0.012319	0	23	67										T	116593033	C	T	116593033	2	4	46	1	0	0	0	0	0	0	0	1	5470	912	32	1		1	FAM160B1	10	116593033	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	530805	116593033	18941714	946	12643										
RAB11FIP2	22841	broad.mit.edu	37	chr10	119799772	119799772	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgcgctgacgagagtcgctGaggacccaagagaaaaggct	14	9	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:119799772G>A	uc001ldj.1	-	2	1098	c.658C>T	c.(658-660)CAG>TAG	p.Q220*	RAB11FIP2_uc009xyz.1_Nonsense_Mutation_p.Q220*	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	220					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GAGAGTCGCTGAGGACCCAAG	0.438													0	0	0	0.004656	0	27	262										A	119799772	G	A	119799772	4	1	46	1	0	0	0	0	0	1	0	0	12894	1299	45	1	896	1	RAB11FIP2	10	119799772	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3206739	119799772	15734975	947	12644										
PRDX3	10935	broad.mit.edu	37	chr10	120928689	120928689	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttggggaaaaaaacctacCgtaggagaatccggtgtcca	11	8	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:120928689C>T	uc001lec.2	-	6	760	c.717G>A	c.(715-717)ACG>ACA	p.T239T		NM_006793	NP_006784	P30048	PRDX3_HUMAN	peroxiredoxin 3 isoform a precursor	239					cell redox homeostasis|hydrogen peroxide catabolic process|mitochondrion organization|myeloid cell differentiation|negative regulation of kinase activity|positive regulation of cell proliferation|positive regulation of NF-kappaB transcription factor activity|regulation of mitochondrial membrane potential|response to lipopolysaccharide	early endosome|mitochondrion	alkyl hydroperoxide reductase activity|caspase inhibitor activity|peroxidase activity|peroxiredoxin activity|protein C-terminus binding|protein kinase binding				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0245)		AAAAACCTACCGTAGGAGAAT	0.512													0	0	0	0.005443	0	26	73										T	120928689	C	T	120928689	2	4	46	1	0	0	0	0	0	0	0	1	12466	666	23	2		2	PRDX3	10	120928689	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1128917	120928689	14606058	948	12645										
BAG3	9531	broad.mit.edu	37	chr10	121411190	121411190	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcagaccccaacccagcatGagcgccgccacccactcgcc	9	21	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:121411190G>A	uc001lem.2	+	1	309	c.3G>A	c.(1-3)ATG>ATA	p.M1I	BAG3_uc001lel.2_Missense_Mutation_p.M1I	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	1					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AACCCAGCATGAGCGCCGCCA	0.756													0	0	0	0.013537	0	11	6										A	121411190	G	A	121411190	3	1	46	1	0	0	0	0	1	0	0	0	1288	1290	45	1	5	1	BAG3	10	121411190	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	482501	121411190	14123557	949	12646										
FGFR2	2263	broad.mit.edu	37	chr10	123239498	123239498	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgtgtcagggtaactaggtGaatactgttcgagaggttgg	15	4	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:123239498G>A	uc010qtk.1	-	19	2986	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	FGFR2_uc010qtg.1_Missense_Mutation_p.S668L|FGFR2_uc010qth.1_Missense_Mutation_p.S665L|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Missense_Mutation_p.S781L|FGFR2_uc010qtl.1_Missense_Mutation_p.S664L|FGFR2_uc010qtm.1_Missense_Mutation_p.S663L|FGFR2_uc001lfg.3_Missense_Mutation_p.S388L|FGFR2_uc001lfk.1_RNA	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	780	Cytoplasmic (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTAACTAGGTGAATACTGTTC	0.443		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.013726	0	33	87										A	123239498	G	A	123239498	3	1	46	1	0	0	0	0	1	0	0	0	5866	1294	45	1	224	1	FGFR2	10	123239498	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1828308	123239498	12295249	950	12647										
FGFR2	2263	broad.mit.edu	37	chr10	123325072	123325072	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagtactccccaataagcaCtgtcctattgttgggcccca	7	14	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:123325072C>T	uc010qtk.1	-	3	903	c.256G>A	c.(256-258)GTG>ATG	p.V86M	FGFR2_uc010qtg.1_Missense_Mutation_p.V86M|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Missense_Mutation_p.V86M|FGFR2_uc010qtl.1_Missense_Mutation_p.V86M|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Missense_Mutation_p.V86M|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_Missense_Mutation_p.V105M|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_Missense_Mutation_p.V105M|FGFR2_uc010qtp.1_Missense_Mutation_p.V105M|FGFR2_uc010qtq.1_Missense_Mutation_p.V105M	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	86	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CCAATAAGCACTGTCCTATTG	0.552		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.005443	0	26	80										T	123325072	C	T	123325072	3	4	46	1	0	0	0	0	1	0	0	0	5866	565	20	2	2529	2	FGFR2	10	123325072	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	85574	123325072	12209675	951	12648										
LHPP	64077	broad.mit.edu	37	chr10	126172787	126172787	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagagctggtggggcagcttCagaggctgggatttgacatc	16	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:126172787C>T	uc001lhs.1	+	2	225	c.205C>T	c.(205-207)CAG>TAG	p.Q69*	LHPP_uc001lht.1_Nonsense_Mutation_p.Q69*|LHPP_uc009yai.1_Nonsense_Mutation_p.Q69*	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	69					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		GGGGCAGCTTCAGAGGCTGGG	0.627													0	0	0	0.010729	0	7	34										T	126172787	C	T	126172787	4	4	46	1	0	0	0	0	0	1	0	0	8769	827	29	1	211	1	LHPP	10	126172787	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2847715	126172787	9361960	952	12649										
LHPP	64077	broad.mit.edu	37	chr10	126301921	126301921	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctgctgctgcagcacgccGacaagtgatggcctcctggg	13	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:126301921G>C	uc001lhs.1	+	7	825	c.805G>C	c.(805-807)GAC>CAC	p.D269H	LHPP_uc001lht.1_3'UTR|LHPP_uc009yai.1_Missense_Mutation_p.D186H|LHPP_uc009yaj.1_RNA	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	269					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		GCAGCACGCCGACAAGTGATG	0.388													0	0	0	0.00333	0	22	26										C	126301921	G	C	126301921	3	2	46	1	0	0	0	0	1	0	0	0	8769	1058	37	1	831	1	LHPP	10	126301921	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	129134	126301921	9232826	953	12650										
ZRANB1	54764	broad.mit.edu	37	chr10	126670348	126670348	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtttacatttttccttgagaGaagaacagtggcaagaagac	10	6	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:126670348G>A	uc001lic.2	+	6	1869	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	ZRANB1_uc010qug.1_Missense_Mutation_p.E526K	NM_017580	NP_060050	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	500	OTU.|TRAF-binding.				positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		TTCCTTGAGAGAAGAACAGTG	0.378													0	0	0	0.006122	0	17	51										A	126670348	G	A	126670348	3	1	46	1	0	0	0	0	1	0	0	0	18219	943	33	1	1520	1	ZRANB1	10	126670348	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	368427	126670348	8864399	954	12651										
DHX32	55760	broad.mit.edu	37	chr10	127525285	127525285	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgcatctctgttcagtttCagggcacgtctcacacattt	8	11	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:127525285C>T	uc001ljf.1	-	11	2694	c.2203G>A	c.(2203-2205)GAA>AAA	p.E735K	BCCIP_uc001ljd.3_Intron|DHX32_uc001lje.1_Missense_Mutation_p.E359K|DHX32_uc001ljg.1_Missense_Mutation_p.E735K|BCCIP_uc010qui.1_Intron|BCCIP_uc001ljc.3_Intron|BCCIP_uc010quj.1_Intron	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	735						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGTTCAGTTTCAGGGCACGTC	0.498													0	0	0	0.00245	0	15	38										T	127525285	C	T	127525285	3	4	46	1	0	0	0	0	1	0	0	0	4505	835	29	1	32	1	DHX32	10	127525285	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	854937	127525285	8009462	955	12652										
GLRX3	10539	broad.mit.edu	37	chr10	131964842	131964842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagttttgatatcttctcaGatgaagaggttcgacaggga	12	6	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:131964842G>A	uc001lkm.1	+	5	572	c.550G>A	c.(550-552)GAT>AAT	p.D184N	GLRX3_uc001lkn.1_Missense_Mutation_p.D184N|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	184	Glutaredoxin 1.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TATCTTCTCAGATGAAGAGGT	0.383													0	0	0	0.00278	0	24	100										A	131964842	G	A	131964842	3	1	46	1	0	0	0	0	1	0	0	0	6461	942	33	1	568	1	GLRX3	10	131964842	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4439557	131964842	3569905	956	12653										
DPYSL4	10570	broad.mit.edu	37	chr10	134015509	134015509	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagtacaaatgctgccaaAatcttcaatttttacccaag	4	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134015509A>C	uc009ybb.2	+	11	1324	c.1170A>C	c.(1168-1170)AAA>AAC	p.K390N		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	390					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		ATGCTGCCAAAATCTTCAATT	0.557													0	0	0	0.00333	0	23	126										C	134015509	A	C	134015509	3	2	46	1	0	0	0	0	1	0	0	0	4749	11	1	5	1212	5	DPYSL4	10	134015509	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	2050667	134015509	1519238	957	12654										
PWWP2B	170394	broad.mit.edu	37	chr10	134218707	134218707	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgccaggaggagcaagaggGagaggcgcgaggaggacagg	21	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134218707G>A	uc001lll.3	+	2	732	c.703G>A	c.(703-705)GAG>AAG	p.E235K	PWWP2B_uc009ybe.2_Missense_Mutation_p.E235K	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	235											0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GAGCAAGAGGGAGAGGCGCGA	0.716													0	0	0	0.004672	0	3	7										A	134218707	G	A	134218707	3	1	46	1	0	0	0	0	1	0	0	0	12846	1175	41	1	709	1	PWWP2B	10	134218707	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	203198	134218707	1316040	958	12655										
C10orf91	170393	broad.mit.edu	37	chr10	134261557	134261557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtttcaggaatgcggccttcGaagcctgaagcggggaatgg	16	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134261557G>A	uc001llm.2	+	3	470	c.430G>A	c.(430-432)GAA>AAA	p.E144K		NM_173541	NP_775812	Q5T1B1	CJ091_HUMAN	hypothetical protein LOC170393	144										ovary(1)	1		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		TGCGGCCTTCGAAGCCTGAAG	0.662													0	0	0	0.00333	0	22	109										A	134261557	G	A	134261557	3	1	46	1	0	0	0	0	1	0	0	0	1624	1059	37	1	440	1	C10orf91	10	134261557	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	42850	134261557	1273190	959	12656										
INPP5A	3632	broad.mit.edu	37	chr10	134511403	134511403	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctggagaaggagaagtttCcgcaggactacttccccgag	13	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134511403C>T	uc001llp.2	+	6	702	c.454C>T	c.(454-456)CCG>TCG	p.P152S	INPP5A_uc001llo.1_Missense_Mutation_p.P152S|INPP5A_uc001llq.2_Missense_Mutation_p.P104S	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	152				PQDYFPECKWSRKGFIRTRWC -> RRLLPRVQMVKKRLHP DEVV (in Ref. 5; CAA83500).	cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		GGAGAAGTTTCCGCAGGACTA	0.498													0	0	0	0.010729	0	10	34										T	134511403	C	T	134511403	3	4	46	1	0	0	0	0	1	0	0	0	7754	855	30	1	476	1	INPP5A	10	134511403	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	249846	134511403	1023344	960	12657										
HRAS	3265	broad.mit.edu	37	chr11	533785	533785	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgtactggtggatgtcctCaaaagacttggtgttgttga	12	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:533785C>T	uc001lpv.2	-	3	459	c.271G>A	c.(271-273)GAG>AAG	p.E91K	HRAS_uc010qvw.1_Missense_Mutation_p.E91K|HRAS_uc010qvx.1_Missense_Mutation_p.E91K|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	91					activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TGGATGTCCTCAAAAGACTTG	0.657		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.010504	0	20	35										T	533785	C	T	533785	3	4	46	1	0	0	0	0	1	0	0	0	7348	835	29	1	377	1	HRAS	11	533785	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		533785	134472731	961	12658										
RASSF7	8045	broad.mit.edu	37	chr11	563424	563424	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctccagccagagaggagtCcctcctgggcgctccctctg	12	17	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:563424C>T	uc001lqc.2	+	5	1015	c.980C>T	c.(979-981)TCC>TTC	p.S327F	C11orf35_uc001lpx.2_5'Flank|RASSF7_uc001lqa.2_3'UTR|RASSF7_uc001lqb.2_3'UTR|RASSF7_uc001lqd.2_Intron	NM_003475	NP_003466	Q02833	RASF7_HUMAN	Ras association (RalGDS/AF-6) domain family	327					regulation of transcription, DNA-dependent|signal transduction	nucleus	DNA binding|protein binding			skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGAGAGGAGTCCCTCCTGGGC	0.697													0	0	0	0.001168	0	5	12										T	563424	C	T	563424	3	4	46	1	0	0	0	0	1	0	0	0	13091	855	30	1	1057	1	RASSF7	11	563424	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	29639	563424	134443092	962	12659										
PHRF1	57661	broad.mit.edu	37	chr11	597514	597514	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagccaggacacggcagagtGagagagtgagagcaaccgtg	16	8	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:597514G>A	uc001lqe.2	+	8	969	c.838G>A	c.(838-840)GAG>AAG	p.E280K	PHRF1_uc010qwc.1_Missense_Mutation_p.E280K|PHRF1_uc010qwd.1_Missense_Mutation_p.E279K|PHRF1_uc010qwe.1_Missense_Mutation_p.E276K|PHRF1_uc009ybz.1_Missense_Mutation_p.E71K	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	280	Arg-rich.						RNA polymerase binding|zinc ion binding				0						ACGGCAGAGTGAGAGAGTGAG	0.662													0	0	0	0.000602	0	5	17										A	597514	G	A	597514	3	1	46	1	0	0	0	0	1	0	0	0	11861	1291	45	1	864	1	PHRF1	11	597514	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	34090	597514	134409002	963	12660										
CDHR5	53841	broad.mit.edu	37	chr11	617418	617419	+	Missense_Mutation	DNP	TC	TC	AT													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctccccgcgccctcgcccTcatcgccgctgccggagtca					rs76054644		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:617418_617419TC>AT	uc001lqj.2	-	15	2575_2576	c.2470_2471GA>AT	c.(2470-2472)GAG>ATG	p.E824M	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Missense_Mutation_p.E630M|CDHR5_uc009ycc.2_Missense_Mutation_p.E658M|CDHR5_uc009ycd.2_Missense_Mutation_p.E818M|CDHR5_uc001lql.2_Missense_Mutation_p.E824M	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	824	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GCCCTCGCCCTCATCGCCGCTG	0.688													0	0	0	0.004672	0	4	11										AT	617419	TC	AT	617418	3	1	46	1	0	0	0	0	1	0	0	0	3122	1551	54	5	70	5	CDHR5	11	617418	Missense_Mutation	DNP	TC	TCGA-DK-A1AC-01A-11D-A13W-08	19904	617418	134389098	964	12661										
TMEM80	283232	broad.mit.edu	37	chr11	702971	702971	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggcaacctgacagaggctGagaggccgctggccgccagc	17	13	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:702971G>A	uc001lqr.2	+	5	465	c.328G>A	c.(328-330)GAG>AAG	p.E110K	TMEM80_uc001lqs.2_Missense_Mutation_p.E102K|TMEM80_uc010qwi.1_Missense_Mutation_p.E110K	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	110						integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACAGAGGCTGAGAGGCCGCT	0.692													0	0	0	0.010729	0	11	36										A	702971	G	A	702971	3	1	46	1	0	0	0	0	1	0	0	0	16201	1291	45	1	346	1	TMEM80	11	702971	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	85553	702971	134303545	965	12662										
TMEM80	283232	broad.mit.edu	37	chr11	703075	703075	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgtgggcggactgggccctCagcgccacgctcctggccct	14	16	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:703075C>T	uc001lqr.2	+	5	569	c.432C>T	c.(430-432)CTC>CTT	p.L144L	TMEM80_uc001lqs.2_Silent_p.L136L|TMEM80_uc010qwi.1_Silent_p.L144L	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	144	Helical; (Potential).					integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACTGGGCCCTCAGCGCCACGC	0.701													0	0	0	0.001984	0	7	35										T	703075	C	T	703075	2	4	46	1	0	0	0	0	0	0	0	1	16201	813	29	1		1	TMEM80	11	703075	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	104	703075	134303441	966	12663										
MUC2	4583	broad.mit.edu	37	chr11	1081800	1081800	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttggacgatccctgctccctGaacatcgagagcggtgaggc	13	12	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1081800G>A	uc001lsx.1	+	13	1755	c.1728G>A	c.(1726-1728)CTG>CTA	p.L576L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	576	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCTGCTCCCTGAACATCGAGA	0.677													0	0	0	0.006122	0	16	20										A	1081800	G	A	1081800	2	1	46	1	0	0	0	0	0	0	0	1	9975	1277	45	1		1	MUC2	11	1081800	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	378725	1081800	133924716	967	12664										
MUC5B	727897	broad.mit.edu	37	chr11	1276623	1276623	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgccccacagggtctttgctGagtgccacaaccttgtgccc	10	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1276623G>A	uc009ycr.1	+	59	17038	c.16912G>A	c.(16912-16914)GAG>AAG	p.E5638K	MUC5B_uc001ltb.2_Missense_Mutation_p.E5304K	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5301	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTCTTTGCTGAGTGCCACAA	0.597													0	0	0	0.000602	0	4	5										A	1276623	G	A	1276623	3	1	46	1	0	0	0	0	1	0	0	0	9979	1291	45	1	16056	1	MUC5B	11	1276623	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	194823	1276623	133729893	968	12665										
SYT8	90019	broad.mit.edu	37	chr11	1856335	1856335	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaaaccagcagggtagaaaGatggggcacccaccagtctc	11	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1856335G>A	uc001lue.1	+	2	170	c.42G>A	c.(40-42)AAG>AAA	p.K14K	SYT8_uc010qxb.1_5'UTR|SYT8_uc001lud.2_Silent_p.K14K|SYT8_uc001luf.1_5'UTR|SYT8_uc009ydb.1_5'UTR	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	14	Extracellular (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGGGTAGAAAGATGGGGCACC	0.657													0	0	0	0.001168	0	6	34										A	1856335	G	A	1856335	2	1	46	1	0	0	0	0	0	0	0	1	15477	933	33	1		1	SYT8	11	1856335	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	579712	1856335	133150181	969	12666			2	47		3	3	209	N	G_C_A	6.974953e-05
SYT8	90019	broad.mit.edu	37	chr11	1856355	1856355	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatggggcacccaccagtctCtcccagtgccccggccccag	11	19	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1856355C>G	uc001lue.1	+	2	190	c.62C>G	c.(61-63)TCT>TGT	p.S21C	SYT8_uc010qxb.1_Missense_Mutation_p.S7C|SYT8_uc001lud.2_Missense_Mutation_p.S21C|SYT8_uc001luf.1_Missense_Mutation_p.S7C|SYT8_uc009ydb.1_Missense_Mutation_p.S7C	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	21	Extracellular (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCACCAGTCTCTCCCAGTGCC	0.662													0	0	0	0.000602	0	5	37										G	1856355	C	G	1856355	3	3	46	1	0	0	0	0	1	0	0	0	15477	913	32	1	68	1	SYT8	11	1856355	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	20	1856355	133150161	970	12667			2	47		3	3	209	N	G_C_A	6.974953e-05
SYT8	90019	broad.mit.edu	37	chr11	1856543	1856543	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagggccccgctgggctctcAttgccggcgcccttgccgcg	14	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1856543A>C	uc001lue.1	+	3	282	c.154A>C	c.(154-156)ATT>CTT	p.I52L	SYT8_uc010qxb.1_Missense_Mutation_p.I38L|SYT8_uc001lud.2_Missense_Mutation_p.I52L|SYT8_uc001luf.1_Missense_Mutation_p.I38L|SYT8_uc009ydb.1_Missense_Mutation_p.I38L	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	52	Helical; Signal-anchor for type III membrane protein; (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CTGGGCTCTCATTGCCGGCGC	0.677													0	0	0	0.003954	0	20	42										C	1856543	A	C	1856543	3	2	46	1	0	0	0	0	1	0	0	0	15477	217	8	5	164	5	SYT8	11	1856543	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	188	1856543	133149973	971	12668			2	47		3	3	209	N	G_C_A	6.974953e-05
NUP98	4928	broad.mit.edu	37	chr11	3707310	3707310	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaccttcacactgcgctgaGagatgggtgtagttaagagc	12	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:3707310G>C	uc001lyh.2	-	29	4860	c.4569C>G	c.(4567-4569)CTC>CTG	p.L1523L	NUP98_uc001lyi.2_Intron|NUP98_uc001lyg.2_Silent_p.L488L	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1540					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ACTGCGCTGAGAGATGGGTGT	0.557			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.004007	0	17	82										C	3707310	G	C	3707310	2	2	46	1	0	0	0	0	0	0	0	1	10773	929	33	1		1	NUP98	11	3707310	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1850767	3707310	131299206	972	12669										
OR51D1	390038	broad.mit.edu	37	chr11	4661061	4661061	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtccctatcatagccacttCaaatggaaatctggtccacg	8	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:4661061C>G	uc010qyk.1	+	1	41	c.41C>G	c.(40-42)TCA>TGA	p.S14*		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGCCACTTCAAATGGAAAT	0.473													0	0	0	0.009535	0	29	145										G	4661061	C	G	4661061	4	3	46	1	0	0	0	0	0	1	0	0	11093	838	29	1	43	1	OR51D1	11	4661061	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	953751	4661061	130345455	973	12670										
OR51L1	119682	broad.mit.edu	37	chr11	5020915	5020915	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggatattgcatctcgtgaaGagcagctaaaggcactcaac	10	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5020915G>C	uc010qyu.1	+	1	703	c.703G>C	c.(703-705)GAG>CAG	p.E235Q		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCTCGTGAAGAGCAGCTAAA	0.423													0	0	0	0.00499	0	18	82										C	5020915	G	C	5020915	3	2	46	1	0	0	0	0	1	0	0	0	11102	943	33	1	705	1	OR51L1	11	5020915	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	359854	5020915	129985601	974	12671										
OR52A1	23538	broad.mit.edu	37	chr11	5173165	5173165	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtacgaccatagttcctatCtgaatgacaagctggtgggt	11	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5173165C>G	uc010qyy.1	-	1	435	c.435G>C	c.(433-435)CAG>CAC	p.Q145H		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGTTCCTATCTGAATGACAA	0.483													0	0	0	0.00278	0	23	51										G	5173165	C	G	5173165	3	3	46	1	0	0	0	0	1	0	0	0	11108	912	32	1	505	1	OR52A1	11	5173165	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	152250	5173165	129833351	975	12672										
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5624476	5624476	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgtttgttcatctacctagGattctacaggcaggaaacat	8	8	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5624476G>A	uc001mbf.2	+	2	262	c.18G>A	c.(16-18)AGG>AGA	p.R6R	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_5'UTR|TRIM6_uc010qzj.1_Intron|TRIM6_uc001mbc.1_5'UTR|TRIM6_uc001mbe.2_Intron|TRIM6_uc010qzk.1_Intron|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Silent_p.R6R|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	6						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ATCTACCTAGGATTCTACAGG	0.473													0	0	0	0.003954	0	25	39										A	5624476	G	A	5624476	2	1	46	1	0	0	0	0	0	0	0	1	16531	1188	41	1		1	TRIM6-TRIM34	11	5624476	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	451311	5624476	129382040	976	12673										
TRIM6-TRIM34	445372	broad.mit.edu	37	chr11	5624860	5624860	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catggagaaaaactgcagctCttctgtcaggaggatgggaa	13	7	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5624860C>G	uc001mbf.2	+	2	646	c.402C>G	c.(400-402)CTC>CTG	p.L134L	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Intron|TRIM6_uc010qzj.1_5'UTR|TRIM6_uc001mbc.1_Silent_p.L106L|TRIM6_uc001mbe.2_5'UTR|TRIM6_uc010qzk.1_Intron|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Silent_p.L134L|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	134						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AACTGCAGCTCTTCTGTCAGG	0.557													0	0	0	0.009718	0	40	65										G	5624860	C	G	5624860	2	3	46	1	0	0	0	0	0	0	0	1	16531	900	32	1		1	TRIM6-TRIM34	11	5624860	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	384	5624860	129381656	977	12674										
TAF10	6881	broad.mit.edu	37	chr11	6632638	6632638	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catgcgtgggtctgaggcctCaaagccagcacggttcaggt	14	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6632638C>T	uc001mej.1	-	3	458	c.433G>A	c.(433-435)GAG>AAG	p.E145K		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	145					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCTGAGGCCTCAAAGCCAGCA	0.493													0	0	0	0.012319	0	21	18										T	6632638	C	T	6632638	3	4	46	1	0	0	0	0	1	0	0	0	15511	835	29	1	235	1	TAF10	11	6632638	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1007778	6632638	128373878	978	12675										
TAF10	6881	broad.mit.edu	37	chr11	6632654	6632654	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcaaagccagcacggttCaggtagtaaccagtcactgc	10	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6632654C>T	uc001mej.1	-	3	442	c.417G>A	c.(415-417)CTG>CTA	p.L139L		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	139					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGCACGGTTCAGGTAGTAAC	0.502													0	0	0	0.007413	0	18	15										T	6632654	C	T	6632654	2	4	46	1	0	0	0	0	0	0	0	1	15511	813	29	1		1	TAF10	11	6632654	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	16	6632654	128373862	979	12676										
DCHS1	8642	broad.mit.edu	37	chr11	6648801	6648801	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccatcccgggcctctatcctCagctggaaagctggctccac	9	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6648801C>G	uc001mem.1	-	14	5879	c.5469G>C	c.(5467-5469)CTG>CTC	p.L1823L		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1823	Cadherin 17.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCTATCCTCAGCTGGAAAG	0.577													0	0	0	0.006214	0	9	16										G	6648801	C	G	6648801	2	3	46	1	0	0	0	0	0	0	0	1	4287	813	29	1		1	DCHS1	11	6648801	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	16147	6648801	128357715	980	12677										
DCHS1	8642	broad.mit.edu	37	chr11	6661224	6661225	+	Missense_Mutation	DNP	CC	CC	TA													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatcagctgtggctgaggttCcaactcatagtccagtgagg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6661224_6661225CC>TA	uc001mem.1	-	2	2030_2031	c.1620_1621GG>TA	c.(1618-1623)TTGGAA>TTTAAA	p.540_541LE>FK		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	540_541	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTGAGGTTCCAACTCATAGT	0.569													0	0	0	0.004672	0	11	33										TA	6661225	CC	TA	6661224	3	4	46	1	0	0	0	0	1	0	0	0	4287	864	30	1	8355	1	DCHS1	11	6661224	Missense_Mutation	DNP	CC	TCGA-DK-A1AC-01A-11D-A13W-08	12423	6661224	128345292	981	12678	60	2								
DCHS1	8642	broad.mit.edu	37	chr11	6661230	6661230	+	Missense_Mutation	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgtggctgaggttccaactCatagtccagtgaggcagccg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6661230C>T	uc001mem.1	-	2	2025	c.1615G>A	c.(1615-1617)GAG>AAG	p.E539K		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	539	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTTCCAACTCATAGTCCAGT	0.582													0	0	0	0.003163	0	11	33										T	6661230	C	T	6661230	3	4	46	1	0	0	0	0	1	0	0	0	4287	835	29	1	8361	1	DCHS1	11	6661230	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6	6661230	128345286	982	12679	60	2								
MRPL17	63875	broad.mit.edu	37	chr11	6704022	6704022	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catggctcgttcgttagtgtCtcccagcttcccatagtcga	9	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6704022C>T	uc001men.2	-	2	304	c.199G>A	c.(199-201)GAC>AAC	p.D67N		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	67					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCGTTAGTGTCTCCCAGCTTC	0.532													0	0	0	0.005443	0	23	9										T	6704022	C	T	6704022	3	4	46	1	0	0	0	0	1	0	0	0	9782	913	32	1	336	1	MRPL17	11	6704022	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	42792	6704022	128302494	983	12680										
OLFML1	283298	broad.mit.edu	37	chr11	7509610	7509610	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaatgttgctccaagaagctGaagaagagaaaaagatccgg	11	6	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:7509610G>A	uc001mfi.2	+	2	734	c.382G>A	c.(382-384)GAA>AAA	p.E128K	uc001mff.1_Intron|OLFML1_uc001mfh.1_Missense_Mutation_p.E128K|OLFML1_uc010raz.1_Intron|OLFML1_uc010rba.1_Missense_Mutation_p.E128K	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	128	Potential.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CCAAGAAGCTGAAGAAGAGAA	0.458													0	0	0	0.00308	0	7	15										A	7509610	G	A	7509610	3	1	46	1	0	0	0	0	1	0	0	0	10856	1291	45	1	388	1	OLFML1	11	7509610	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	805588	7509610	127496906	984	12681										
EIF3F	8665	broad.mit.edu	37	chr11	8014480	8014480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcactctgtgctgatccacGagtactacagccgagaggcc	11	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:8014480G>A	uc001mfw.2	+	4	595	c.562G>A	c.(562-564)GAG>AAG	p.E188K	EIF3F_uc010rbj.1_Missense_Mutation_p.E39K	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,	188	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTGATCCACGAGTACTACAG	0.542													0	0	0	0.01441	0	62	46										A	8014480	G	A	8014480	3	1	46	1	0	0	0	0	1	0	0	0	5016	1059	37	1	576	1	EIF3F	11	8014480	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	504870	8014480	126992036	985	12682										
SCUBE2	57758	broad.mit.edu	37	chr11	9088303	9088303	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatggcagctgcactctgggCcatcggctgtatcgtcacag	13	12	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9088303C>A	uc001mhh.1	-	6	781	c.701G>T	c.(700-702)GGC>GTC	p.G234V	SCUBE2_uc001mhi.1_Missense_Mutation_p.G234V|SCUBE2_uc001mhj.1_Missense_Mutation_p.G234V	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	234	EGF-like 5 (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GCACTCTGGGCCATCGGCTGT	0.537													1	0	5.35267e-07	0.007413	5.50488e-07	16	10										A	9088303	C	A	9088303	3	1	46	1	0	0	0	0	1	0	0	0	13945	739	26	4	2457	4	SCUBE2	11	9088303	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1073823	9088303	125918213	986	12683										
IPO7	10527	broad.mit.edu	37	chr11	9424908	9424908	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaacagctggatttacctgtGagacaggcaggcaagtttcc	12	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9424908G>C	uc001mho.2	+	2	298	c.156G>C	c.(154-156)GTG>GTC	p.V52V		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	52	Importin N-terminal.				interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		ATTTACCTGTGAGACAGGCAG	0.378													0	0	0	0.007413	0	18	49										C	9424908	G	C	9424908	2	2	46	1	0	0	0	0	0	0	0	1	7797	1277	45	1		1	IPO7	11	9424908	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	336605	9424908	125581608	987	12684										
WEE1	7465	broad.mit.edu	37	chr11	9597434	9597434	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgtatttttctttccctaGagtttgctctccaaagctcg	6	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9597434G>A	uc001mhs.2	+	2	830	c.577_splice	c.e2-1	p.S193_splice	WEE1_uc001mht.2_Splice_Site|WEE1_uc001mhu.2_5'UTR	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1						blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TCTTTCCCTAGAGTTTGCTCT	0.413													0	0	0	0.006214	0	10	56										A	9597434	G	A	9597434	5	1	46	1	0	0	0	0	0	0	1	0	17341	956	33	1	582	1	WEE1	11	9597434	Splice_Site	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	172526	9597434	125409082	988	12685										
WEE1	7465	broad.mit.edu	37	chr11	9598771	9598771	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatatttctctgcgtgggcaGaagatgatcatatgcttata	10	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9598771G>A	uc001mhs.2	+	5	1355	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K	WEE1_uc001mht.2_Missense_Mutation_p.E154K|WEE1_uc001mhu.2_Missense_Mutation_p.E154K	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1	368	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TGCGTGGGCAGAAGATGATCA	0.373													0	0	0	0.003954	0	24	138										A	9598771	G	A	9598771	3	1	46	1	0	0	0	0	1	0	0	0	17341	943	33	1	1120	1	WEE1	11	9598771	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1337	9598771	125407745	989	12686										
EIF4G2	1982	broad.mit.edu	37	chr11	10822517	10822517	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatggtctgtacctgtcccaGaggtggtgtttgagtgcgtg	15	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:10822517G>A	uc001mjc.2	-	15	1948	c.1531C>T	c.(1531-1533)CTG>TTG	p.L511L	EIF4G2_uc001mjb.2_Silent_p.L305L|EIF4G2_uc009ygf.2_Silent_p.L305L|EIF4G2_uc001mjd.2_Silent_p.L473L|EIF4G2_uc001mjf.1_Silent_p.L267L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	511					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ACCTGTCCCAGAGGTGGTGTT	0.413													0	0	0	0.004878	0	38	134										A	10822517	G	A	10822517	2	1	46	1	0	0	0	0	0	0	0	1	5037	933	33	1		1	EIF4G2	11	10822517	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1223746	10822517	124183999	990	12687										
PLEKHA7	144100	broad.mit.edu	37	chr11	16838617	16838617	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgtggggctgccgtgccgGaactgctggcgctgctgcca	17	13	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:16838617G>C	uc001mmo.2	-	11	1611	c.1596C>G	c.(1594-1596)TTC>TTG	p.F532L	PLEKHA7_uc010rcu.1_Missense_Mutation_p.F532L|PLEKHA7_uc010rcv.1_Missense_Mutation_p.F106L|PLEKHA7_uc001mmn.2_Missense_Mutation_p.F240L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	532					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TGCCGTGCCGGAACTGCTGGC	0.677													0	0	0	0.010729	0	11	20										C	16838617	G	C	16838617	3	2	46	1	0	0	0	0	1	0	0	0	12061	1165	41	1	1821	1	PLEKHA7	11	16838617	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6016100	16838617	118167899	991	12688										
PIK3C2A	5286	broad.mit.edu	37	chr11	17121480	17121480	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctaacgtatttcaaatcttGaatacttgtaagttctggta	6	6	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:17121480G>C	uc001mmq.3	-	25	4111	c.4045C>G	c.(4045-4047)CAA>GAA	p.Q1349E	PIK3C2A_uc009ygu.1_5'UTR|PIK3C2A_uc010rcw.1_Missense_Mutation_p.Q969E|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1349	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTCAAATCTTGAATACTTGTA	0.333													0	0	0	0.014323	0	22	88										C	17121480	G	C	17121480	3	2	46	1	0	0	0	0	1	0	0	0	11909	1299	45	1	1047	1	PIK3C2A	11	17121480	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	282863	17121480	117885036	992	12689										
SAA4	6291	broad.mit.edu	37	chr11	18253209	18253209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgaagatagaccctggaaCggctgcaacccaaagaaagg	11	11	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:18253209C>T	uc001mny.2	-	4	329	c.233G>A	c.(232-234)CGT>CAT	p.R78H		NM_006512	NP_006503	P35542	SAA4_HUMAN	serum amyloid A4, constitutive precursor	78					acute-phase response	high-density lipoprotein particle					0						GACCCTGGAACGGCTGCAACC	0.488													0	0	0	0.00308	0	8	47										T	18253209	C	T	18253209	3	4	46	1	0	0	0	0	1	0	0	0	13800	536	19	2	163	2	SAA4	11	18253209	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1131729	18253209	116753307	993	12690										
CSRP3	8048	broad.mit.edu	37	chr11	19204293	19204293	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaaatttttggcatagcaaActgtgaatgagaagaggatg	11	4	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:19204293A>T	uc001mpk.2	-	6	626	c.509T>A	c.(508-510)GTT>GAT	p.V170D		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	170	LIM zinc-binding 2.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						GGCATAGCAAACTGTGAATGA	0.428													0	0	0	0.00333	0	24	65										T	19204293	A	T	19204293	3	4	46	1	0	0	0	0	1	0	0	0	3969	57	2	5	79	5	CSRP3	11	19204293	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	951084	19204293	115802223	994	12691										
FANCF	2188	broad.mit.edu	37	chr11	22646239	22646239	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacacagcattgcctatacaGaactgaggcctgcgctgaga	10	11	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:22646239G>A	uc001mql.1	-	1	1149	c.1118C>T	c.(1117-1119)TCT>TTT	p.S373F		NM_022725	NP_073562	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	373					DNA repair	nucleoplasm	protein binding			skin(1)	1						TGCCTATACAGAACTGAGGCC	0.383			N|F			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.010771	0	42	56										A	22646239	G	A	22646239	3	1	46	1	0	0	0	0	1	0	0	0	5667	942	33	1	10	1	FANCF	11	22646239	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3441946	22646239	112360277	995	12692										
GAS2	2620	broad.mit.edu	37	chr11	22707331	22707331	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catggatgctaacaagcccaCaaaggtaaaagatcccaatg	8	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:22707331C>T	uc009yie.2	+	3	569	c.263C>T	c.(262-264)ACA>ATA	p.T88I	GAS2_uc001mqm.2_Missense_Mutation_p.T88I|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.T88I	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	88	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						AACAAGCCCACAAAGGTAAAA	0.358													0	0	0	0.00632	0	29	32										T	22707331	C	T	22707331	3	4	46	1	0	0	0	0	1	0	0	0	6245	478	17	2	269	2	GAS2	11	22707331	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	61092	22707331	112299185	996	12693										
LUZP2	338645	broad.mit.edu	37	chr11	25004745	25004745	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttccgtgatcagcctcctcCccctttgagtttaatcacat	5	14	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:25004745C>A	uc001mqs.2	+	9	905	c.671C>A	c.(670-672)CCC>CAC	p.P224H	LUZP2_uc009yif.2_Missense_Mutation_p.P138H|LUZP2_uc009yig.2_Missense_Mutation_p.P182H	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	224	Poly-Pro.					extracellular region				ovary(1)|skin(1)	2						CAGCCTCCTCCCCCTTTGAGT	0.448													1	0	4.41824e-40	0.01441	4.69519e-40	82	80										A	25004745	C	A	25004745	3	1	46	1	0	0	0	0	1	0	0	0	9087	623	22	4	705	4	LUZP2	11	25004745	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2297414	25004745	110001771	997	12694										
ANO3	63982	broad.mit.edu	37	chr11	26465320	26465320	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attttatttcagttaatactGaggagaataaaaacgactct	6	5	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:26465320G>A	uc001mqt.3	+	3	395	c.250G>A	c.(250-252)GAG>AAG	p.E84K	ANO3_uc010rdr.1_Missense_Mutation_p.E68K	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	84	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGTTAATACTGAGGAGAATAA	0.338													0	0	0	0.010729	0	10	28										A	26465320	G	A	26465320	3	1	46	1	0	0	0	0	1	0	0	0	698	1291	45	1	260	1	ANO3	11	26465320	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1460575	26465320	108541196	998	12695										
NAT10	55226	broad.mit.edu	37	chr11	34167693	34167693	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcaagaagttgaagaacaGagagacaaagaacaaaaaag	11	4	0	6			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:34167693G>C	uc001mvk.2	+	29	3276	c.3032G>C	c.(3031-3033)AGA>ACA	p.R1011T	NAT10_uc010ren.1_Missense_Mutation_p.R939T	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	1011	Lys-rich.|Required for localization to the nucleolus and midbody.					nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				TTGAAGAACAGAGAGACAAAG	0.358													0	0	0	0.004672	0	3	15										C	34167693	G	C	34167693	3	2	46	1	0	0	0	0	1	0	0	0	10174	942	33	1	3142	1	NAT10	11	34167693	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7702373	34167693	100838823	999	12696										
EHF	26298	broad.mit.edu	37	chr11	34680084	34680084	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctgcttttcatcagacccGagagggactcacttatggga	10	10	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:34680084G>A	uc001mvr.1	+	8	723	c.612G>A	c.(610-612)CCG>CCA	p.P204P	EHF_uc009yke.1_Silent_p.P181P|EHF_uc009ykf.1_Silent_p.P207P	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	204					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			CATCAGACCCGAGAGGGACTC	0.468													0	0	0	0.01441	0	50	33										A	34680084	G	A	34680084	2	1	46	1	0	0	0	0	0	0	0	1	4981	1045	37	1		1	EHF	11	34680084	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	512391	34680084	100326432	1000	12697										
CRY2	1408	broad.mit.edu	37	chr11	45889168	45889168	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctttctgctgtaggcctgGgttgccaactatgagagacc	11	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:45889168G>C	uc010rgn.1	+	6	832	c.810G>C	c.(808-810)TGG>TGC	p.W270C	CRY2_uc009ykw.2_Missense_Mutation_p.W188C|CRY2_uc010rgo.1_5'UTR	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	249	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						TGTAGGCCTGGGTTGCCAACT	0.433													0	0	0	0.005443	0	26	75										C	45889168	G	C	45889168	3	2	46	1	0	0	0	0	1	0	0	0	3904	1241	43	4	868	4	CRY2	11	45889168	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	11209084	45889168	89117348	1001	12698										
AMBRA1	55626	broad.mit.edu	37	chr11	46563761	46563761	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acactctcaaaggagctgggGacctgccaagaggaactagc	12	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:46563761G>A	uc010rgu.1	-	7	2166	c.1806C>T	c.(1804-1806)GTC>GTT	p.V602V	AMBRA1_uc010rgt.1_Silent_p.V168V|AMBRA1_uc009ylc.1_Silent_p.V602V|AMBRA1_uc001ncu.1_Silent_p.V512V|AMBRA1_uc001ncv.2_Silent_p.V512V|AMBRA1_uc001ncw.2_Silent_p.V512V|AMBRA1_uc001ncx.2_Silent_p.V602V	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	602	Ser-rich.				autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AGGAGCTGGGGACCTGCCAAG	0.582													0	0	0	0.006214	0	8	28										A	46563761	G	A	46563761	2	1	46	1	0	0	0	0	0	0	0	1	565	1161	41	1		1	AMBRA1	11	46563761	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	674593	46563761	88442755	1002	12699										
F2	2147	broad.mit.edu	37	chr11	46749600	46749600	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgctgtgtggggccagcctCatcagtgaccgctgggtcct	14	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:46749600C>T	uc001ndf.3	+	10	1228	c.1185C>T	c.(1183-1185)CTC>CTT	p.L395L	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	395	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	GGGCCAGCCTCATCAGTGACC	0.627													0	0	0	0.009096	0	4	12										T	46749600	C	T	46749600	2	4	46	1	0	0	0	0	0	0	0	1	5342	813	29	1		1	F2	11	46749600	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	185839	46749600	88256916	1003	12700										
LRP4	4038	broad.mit.edu	37	chr11	46890629	46890629	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttccggcctgagtatttgtCaacacgctggattgacttgg	12	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:46890629C>T	uc001ndn.3	-	32	4893	c.4747G>A	c.(4747-4749)GAC>AAC	p.D1583N	uc001ndl.2_Intron	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1583	Extracellular (Potential).|LDL-receptor class B 20.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GAGTATTTGTCAACACGCTGG	0.507													0	0	0	0.010504	0	21	35										T	46890629	C	T	46890629	3	4	46	1	0	0	0	0	1	0	0	0	8959	826	29	1	998	1	LRP4	11	46890629	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	141029	46890629	88115887	1004	12701										
MYBPC3	4607	broad.mit.edu	37	chr11	47354825	47354825	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggggtggcttccactccaGagccacattaagaccccagg	11	14	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:47354825G>A	uc001nfa.3	-	29	3305	c.3250C>T	c.(3250-3252)CTG>TTG	p.L1084L		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1083	Fibronectin type-III 3.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		TTCCACTCCAGAGCCACATTA	0.617													0	0	0	0.00308	0	7	1										A	47354825	G	A	47354825	2	1	46	1	0	0	0	0	0	0	0	1	10013	933	33	1		1	MYBPC3	11	47354825	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	464196	47354825	87651691	1005	12702										
SLC39A13	91252	broad.mit.edu	37	chr11	47433961	47433961	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgggtcattgctggcatcctGaccttcctggcgttggagaa	13	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:47433961G>A	uc009ylq.2	+	4	651	c.480G>A	c.(478-480)CTG>CTA	p.L160L	SLC39A13_uc001nfd.2_Silent_p.L160L|SLC39A13_uc001nfe.1_RNA|SLC39A13_uc001nff.3_Silent_p.L160L|SLC39A13_uc001nfg.3_Silent_p.L160L	NM_001128225	NP_001121697	Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter),	160	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				Lung(87;0.0936)		CTGGCATCCTGACCTTCCTGG	0.562											OREG0020959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	22										A	47433961	G	A	47433961	2	1	46	1	0	0	0	0	0	0	0	1	14616	1277	45	1		1	SLC39A13	11	47433961	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	79136	47433961	87572555	1006	12703										
AGBL2	79841	broad.mit.edu	37	chr11	47721019	47721019	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaatctaattgatagacaaCtgttccttttttctctccta	4	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:47721019C>T	uc001ngg.2	-	7	773	c.673G>A	c.(673-675)GTT>ATT	p.V225I	AGBL2_uc010rhq.1_Missense_Mutation_p.V187I|AGBL2_uc001ngh.1_Missense_Mutation_p.V169I	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	225					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						TGATAGACAACTGTTCCTTTT	0.333													0	0	0	0.014323	0	21	74										T	47721019	C	T	47721019	3	4	46	1	0	0	0	0	1	0	0	0	376	565	20	2	2083	2	AGBL2	11	47721019	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	287058	47721019	87285497	1007	12704										
OR8J3	81168	broad.mit.edu	37	chr11	55904807	55904807	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccaccaccatgtagagcaGagggttacaaatggccacat	9	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:55904807G>C	uc010riz.1	-	1	388	c.388C>G	c.(388-390)CTG>GTG	p.L130V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ATGTAGAGCAGAGGGTTACAA	0.507													0	0	0	0.005443	0	20	105										C	55904807	G	C	55904807	3	2	46	1	0	0	0	0	1	0	0	0	11242	933	33	1	561	1	OR8J3	11	55904807	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8183788	55904807	79101709	1008	12705										
OR5T2	219464	broad.mit.edu	37	chr11	56000467	56000467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctagaaacaggaagaagaaGatagtctgcagttcaagatt	11	5	2	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:56000467G>C	uc010rjc.1	-	1	195	c.195C>G	c.(193-195)ATC>ATG	p.I65M		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	65	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGAAGAAGAAGATAGTCTGCA	0.388													0	0	0	0.008361	0	32	46										C	56000467	G	C	56000467	3	2	46	1	0	0	0	0	1	0	0	0	11182	932	33	1	883	1	OR5T2	11	56000467	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	95660	56000467	79006049	1009	12706										
OR5M3	219482	broad.mit.edu	37	chr11	56237065	56237065	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgtttaacatgatctgctGatcactttcatcatggcctt	6	9	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:56237065G>A	uc010rjk.1	-	1	909	c.909C>T	c.(907-909)ATC>ATT	p.I303I		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATGATCTGCTGATCACTTTCA	0.343													0	0	0	0.00333	0	18	25										A	56237065	G	A	56237065	2	1	46	1	0	0	0	0	0	0	0	1	11175	1280	45	1		1	OR5M3	11	56237065	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	236598	56237065	78769451	1010	12707										
OR5M3	219482	broad.mit.edu	37	chr11	56237767	56237767	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgacattggaagaaaaccaCacatcaacaaatgacaagtg	8	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:56237767C>T	uc010rjk.1	-	1	207	c.207G>A	c.(205-207)GTG>GTA	p.V69V		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AAGAAAACCACACATCAACAA	0.388													0	0	0	0.01441	0	54	87										T	56237767	C	T	56237767	2	4	46	1	0	0	0	0	0	0	0	1	11175	465	17	2		2	OR5M3	11	56237767	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	702	56237767	78768749	1011	12708										
RTN4RL2	349667	broad.mit.edu	37	chr11	57243799	57243799	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgcgcggccttccgcggcctCagccgcctcaccatcctcta	9	21	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:57243799C>T	uc010rjt.1	+	3	678	c.678C>T	c.(676-678)CTC>CTT	p.L226L		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	226					axon regeneration	anchored to plasma membrane	receptor activity				0						TCCGCGGCCTCAGCCGCCTCA	0.706													0	0	0	0.001855	0	6	8										T	57243799	C	T	57243799	2	4	46	1	0	0	0	0	0	0	0	1	13732	813	29	1		1	RTN4RL2	11	57243799	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1006032	57243799	77762717	1012	12709										
DTX4	23220	broad.mit.edu	37	chr11	58940200	58940200	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccgcgcggggggcagcgtGgtgctgggccaggtggacag	21	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:58940200G>A	uc001nns.2	+	1	389	c.132G>A	c.(130-132)GTG>GTA	p.V44V	DTX4_uc001nnr.2_Intron	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	44	WWE 1.				Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				ggggcAGCGTGGTGCTGGGCC	0.582													0	0	0	0.000602	0	5	1										A	58940200	G	A	58940200	2	1	46	1	0	0	0	0	0	0	0	1	4797	1335	47	2		2	DTX4	11	58940200	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1696401	58940200	76066316	1013	12710										
MS4A2	2206	broad.mit.edu	37	chr11	59856269	59856269	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagtaataggagagcaaatCttgctctcccacaggagcct	9	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:59856269C>T	uc001nop.2	+	1	133	c.31C>T	c.(31-33)CTT>TTT	p.L11F	MS4A2_uc009ymu.2_Missense_Mutation_p.L11F	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	11	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GAGAGCAAATCTTGCTCTCCC	0.413													0	0	0	0.010729	0	11	21										T	59856269	C	T	59856269	3	4	46	1	0	0	0	0	1	0	0	0	9860	913	32	1	33	1	MS4A2	11	59856269	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	916069	59856269	75150247	1014	12711										
MS4A14	84689	broad.mit.edu	37	chr11	60164085	60164085	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccaggacagaagggcaactCacgtcatcactataaaacca	7	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:60164085C>T	uc001npj.2	+	1	599	c.34C>T	c.(34-36)CAC>TAC	p.H12Y	MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.H12Y|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	12						integral to membrane	receptor activity			breast(1)	1						AAGGGCAACTCACGTCATCAC	0.453													0	0	0	0.013537	0	12	27										T	60164085	C	T	60164085	3	4	46	1	0	0	0	0	1	0	0	0	9858	826	29	1	36	1	MS4A14	11	60164085	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	307816	60164085	74842431	1015	12712										
CD6	923	broad.mit.edu	37	chr11	60781007	60781007	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccctcatcttcatagccttCatcctcttgagaattaaagg	5	12	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:60781007C>T	uc001nqq.2	+	7	1486	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	CD6_uc009yni.2_Silent_p.F320F|CD6_uc009ynj.2_Silent_p.F298F|CD6_uc001nqp.2_Silent_p.F421F|CD6_uc001nqr.2_Silent_p.F421F|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.F421F	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	421	Helical; (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						TCATAGCCTTCATCCTCTTGA	0.507													0	0	0	0.01441	0	60	176										T	60781007	C	T	60781007	2	4	46	1	0	0	0	0	0	0	0	1	3028	825	29	1		1	CD6	11	60781007	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	616922	60781007	74225509	1016	12713										
DDB1	1642	broad.mit.edu	37	chr11	61067688	61067688	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcataccgctgccatcgtCatactgcaatgagaagatgg	9	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:61067688C>T	uc001nrc.3	-	27	3569	c.3343G>A	c.(3343-3345)GAC>AAC	p.D1115N		NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	1115	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CTGCCATCGTCATACTGCAAT	0.592								NER					0	0	0	0.001168	0	5	13										T	61067688	C	T	61067688	3	4	46	1	0	0	0	0	1	0	0	0	4323	826	29	1	83	1	DDB1	11	61067688	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	286681	61067688	73938828	1017	12714										
AHNAK	79026	broad.mit.edu	37	chr11	62297473	62297473	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctccttctacttttggaacTgttacatcataatctccttt	3	11	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62297473T>C	uc001ntl.2	-	5	4716	c.4416A>G	c.(4414-4416)ACA>ACG	p.T1472T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1472					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTTTGGAACTGTTACATCAT	0.398													0	0	0	0.01441	0	186	191										C	62297473	T	C	62297473	2	2	46	1	0	0	0	0	0	0	0	1	414	1567	55	5		5	AHNAK	11	62297473	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1229785	62297473	72709043	1018	12715										
EML3	256364	broad.mit.edu	37	chr11	62372641	62372641	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcgggtggaagtcagcacaGagaccagtctcctgggagag	15	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62372641G>C	uc001ntu.1	-	16	2234	c.1926C>G	c.(1924-1926)CTC>CTG	p.L642L	EML3_uc001ntr.1_Silent_p.L614L|EML3_uc001nts.1_Silent_p.L614L|EML3_uc001ntt.1_Silent_p.L526L|EML3_uc010rly.1_Silent_p.L642L	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	642						cytoplasm|microtubule	protein binding			ovary(1)	1						AGTCAGCACAGAGACCAGTCT	0.562													0	0	0	0.004007	0	16	57										C	62372641	G	C	62372641	2	2	46	1	0	0	0	0	0	0	0	1	5098	929	33	1		1	EML3	11	62372641	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	75168	62372641	72633875	1019	12716										
GANAB	23193	broad.mit.edu	37	chr11	62400737	62400737	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgccttcccctgagtctCctctggctgttaagaagaaa	8	13	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62400737C>T	uc001nub.2	-	7	670	c.637G>A	c.(637-639)GAG>AAG	p.E213K	GANAB_uc001nua.2_Missense_Mutation_p.E235K|GANAB_uc001nuc.2_Missense_Mutation_p.E116K|GANAB_uc010rma.1_Missense_Mutation_p.E121K|GANAB_uc010rmb.1_Missense_Mutation_p.E99K	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	213					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CCCTGAGTCTCCTCTGGCTGT	0.522													0	0	0	0.001984	0	7	157										T	62400737	C	T	62400737	3	4	46	1	0	0	0	0	1	0	0	0	6233	864	30	1	2269	1	GANAB	11	62400737	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	28096	62400737	72605779	1020	12717										
GANAB	23193	broad.mit.edu	37	chr11	62406471	62406471	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaccgggctattggtggatCagccaccaaaacatctggta	10	10	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62406471C>T	uc001nub.2	-	4	397	c.364G>A	c.(364-366)GAT>AAT	p.D122N	GANAB_uc001nua.2_Missense_Mutation_p.D122N|GANAB_uc001nuc.2_Missense_Mutation_p.D25N|GANAB_uc010rma.1_Intron|GANAB_uc010rmb.1_Intron	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	122					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						ATTGGTGGATCAGCCACCAAA	0.483													0	0	0	0.007413	0	20	28										T	62406471	C	T	62406471	3	4	46	1	0	0	0	0	1	0	0	0	6233	826	29	1	2624	1	GANAB	11	62406471	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5734	62406471	72600045	1021	12718										
TTC9C	283237	broad.mit.edu	37	chr11	62505817	62505817	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaactcagcagctaccataGaaaagagaagcagctctacc	8	11	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62505817G>C	uc001nuy.2	+	3	848	c.479G>C	c.(478-480)AGA>ACA	p.R160T	TTC9C_uc001nux.2_Missense_Mutation_p.R293T	NM_173810	NP_776171	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	160							binding			ovary(1)|pancreas(1)	2						AGCTACCATAGAAAAGAGAAG	0.458													0	0	0	0.004672	0	3	18										C	62505817	G	C	62505817	3	2	46	1	0	0	0	0	1	0	0	0	16714	942	33	1	489	1	TTC9C	11	62505817	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	99346	62505817	72500699	1022	12719										
ZBTB3	79842	broad.mit.edu	37	chr11	62519909	62519909	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaccccaaagcttcctggagCtgcttcgtactcagaagaca	8	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62519909C>A	uc001nuz.2	-	2	1500	c.1378G>T	c.(1378-1380)GCT>TCT	p.A460S		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						CTTCCTGGAGCTGCTTCGTAC	0.552													1	0	7.11191e-15	0.013726	7.46269e-15	34	60										A	62519909	C	A	62519909	3	1	46	1	0	0	0	0	1	0	0	0	17531	797	28	4	350	4	ZBTB3	11	62519909	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	14092	62519909	72486607	1023	12720										
NXF1	10482	broad.mit.edu	37	chr11	62563940	62563940	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgatactaaccgggcaggGttctgaggaatgaaaggaat	14	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62563940G>C	uc001nvf.1	-	14	1414	c.1278C>G	c.(1276-1278)AAC>AAG	p.N426K	NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Missense_Mutation_p.N469K	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	426	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						ACCGGGCAGGGTTCTGAGGAA	0.562													0	0	0	0.008291	0	10	111										C	62563940	G	C	62563940	3	2	46	1	0	0	0	0	1	0	0	0	10782	1252	44	4	613	4	NXF1	11	62563940	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	44031	62563940	72442576	1024	12721										
SLC22A8	9376	broad.mit.edu	37	chr11	62767306	62767306	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcaggtcaggatgggcctgCggccaaacctgtagctcgaa	14	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62767306C>T	uc001nwo.2	-	4	582	c.446G>A	c.(445-447)CGC>CAC	p.R149H	SLC22A8_uc001nwn.1_5'Flank|SLC22A8_uc001nwp.2_Missense_Mutation_p.R149H|SLC22A8_uc009yom.2_Missense_Mutation_p.R26H|SLC22A8_uc010rmm.1_Missense_Mutation_p.R58H|SLC22A8_uc009yon.2_Missense_Mutation_p.R149H	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	149	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GATGGGCCTGCGGCCAAACCT	0.627													0	0	0	0.000602	0	4	22										T	62767306	C	T	62767306	3	4	46	1	0	0	0	0	1	0	0	0	14460	768	27	2	1214	2	SLC22A8	11	62767306	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	203366	62767306	72239210	1025	12722										
MARK2	2011	broad.mit.edu	37	chr11	63668428	63668428	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgtatgtccccctgtgcaGagctgatggtgtccatgggt	13	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:63668428G>A	uc001nxw.2	+	11	1568	c.989_splice	c.e11-1	p.E330_splice	MARK2_uc001nxx.2_Splice_Site_p.E330_splice|MARK2_uc001nxy.2_Splice_Site_p.E330_splice|MARK2_uc001nxv.3_Splice_Site_p.E330_splice|MARK2_uc001nxz.3_Splice_Site_p.E297_splice|MARK2_uc009yoy.2_Splice_Site_p.E297_splice	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2						cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCCCTGTGCAGAGCTGATGGT	0.577													0	0	0	0.01441	0	49	57										A	63668428	G	A	63668428	5	1	46	1	0	0	0	0	0	0	1	0	9313	956	33	1	1030	1	MARK2	11	63668428	Splice_Site	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	901122	63668428	71338088	1026	12723										
GPR137	56834	broad.mit.edu	37	chr11	64054074	64054074	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgctgtgaccctggggctGacagctgcctacaccaccct	10	17	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64054074G>A	uc001nzg.1	+	2	386	c.78G>A	c.(76-78)CTG>CTA	p.L26L	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Silent_p.L32L|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Silent_p.L84L|GPR137_uc001nze.1_Silent_p.L26L|GPR137_uc001nzf.2_Silent_p.L26L|GPR137_uc001nzh.1_Silent_p.L26L|GPR137_uc001nzi.2_Silent_p.L26L|GPR137_uc010rnj.1_Silent_p.L26L	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	26	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CCCTGGGGCTGACAGCTGCCT	0.617													0	0	0	0.009535	0	29	87										A	64054074	G	A	64054074	2	1	46	1	0	0	0	0	0	0	0	1	6645	1277	45	1		1	GPR137	11	64054074	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	385646	64054074	70952442	1027	12724										
KCNK4	50801	broad.mit.edu	37	chr11	64067112	64067112	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccgctgccccgcgcgccgAgaggtcgccgccgcccaaat	13	20	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64067112A>C	uc001nzj.1	+	7	1419	c.1096A>C	c.(1096-1098)AGA>CGA	p.R366R	KCNK4_uc001nzk.1_Missense_Mutation_p.E250A|KCNK4_uc010rnk.1_Silent_p.R194R|KCNK4_uc001nzl.1_Missense_Mutation_p.E250A|KCNK4_uc001nzm.3_RNA|KCNK4_uc001nzn.1_Silent_p.R366R|KCNK4_uc001nzo.2_Silent_p.R366R|KCNK4_uc001nzp.1_Silent_p.R252R|C11orf20_uc009ypm.2_5'Flank	NM_033310	NP_201567	Q9NYG8	KCNK4_HUMAN	TRAAK	366	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						CCGCGCGCCGAGAGGTCGCCG	0.627													0	0	0	0.000602	0	4	19										C	64067112	A	C	64067112	2	2	46	1	0	0	0	0	0	0	0	1	8068	296	11	5		5	KCNK4	11	64067112	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	13038	64067112	70939404	1028	12725										
TRMT112	51504	broad.mit.edu	37	chr11	64084577	64084577	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagaaactcctcattctcctCatatccctcaaccggccctt	3	18	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64084577C>T	uc001nzt.2	-	3	258	c.223G>A	c.(223-225)GAG>AAG	p.E75K	PRDX5_uc001nzu.2_5'Flank|PRDX5_uc001nzv.2_5'Flank|PRDX5_uc001nzw.2_5'Flank|PRDX5_uc001nzx.2_5'Flank	NM_016404	NP_057488	Q9UI30	TR112_HUMAN	tRNA methyltransferase 11-2 homolog	75	TRM112.				peptidyl-glutamine methylation	protein complex	protein binding|protein methyltransferase activity				0						TCATTCTCCTCATATCCCTCA	0.617													0	0	0	0.009535	0	27	29										T	64084577	C	T	64084577	3	4	46	1	0	0	0	0	1	0	0	0	16560	835	29	1	162	1	TRMT112	11	64084577	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	17465	64084577	70921939	1029	12726										
RPS6KA4	8986	broad.mit.edu	37	chr11	64138842	64138842	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcggaagcagaagctgcggAgcgccaccgcctcccgccgg	16	16	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64138842A>T	uc001oae.2	+	17	2292	c.2209A>T	c.(2209-2211)AGC>TGC	p.S737C	RPS6KA4_uc001oad.2_Missense_Mutation_p.S731C|RPS6KA4_uc010rnl.1_Missense_Mutation_p.S674C|RPS6KA4_uc001oaf.2_Missense_Mutation_p.S730C|RPS6KA4_uc009ypp.2_Missense_Mutation_p.S489C	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	737					axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						GAAGCTGCGGAGCGCCACCGC	0.721													0	0	0	0.001168	0	4	20										T	64138842	A	T	64138842	3	4	46	1	0	0	0	0	1	0	0	0	13653	304	11	5	2275	5	RPS6KA4	11	64138842	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	54265	64138842	70867674	1030	12727										
SF1	7536	broad.mit.edu	37	chr11	64536954	64536954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcagtaaccagggcatgaaGtggctcatcttctcctggca	12	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64536954G>A	uc001obb.1	-	6	984	c.607C>T	c.(607-609)CTT>TTT	p.L203F	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.L177F|SF1_uc001oaz.1_Missense_Mutation_p.L328F|SF1_uc001oba.1_Missense_Mutation_p.L203F|SF1_uc001obc.1_Missense_Mutation_p.L203F|SF1_uc001obd.1_Missense_Mutation_p.L203F|SF1_uc001obe.1_Missense_Mutation_p.L88F|SF1_uc010rno.1_Missense_Mutation_p.L88F	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	203	KH.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						AGGGCATGAAGTGGCTCATCT	0.522													0	0	0	0.01441	0	141	243										A	64536954	G	A	64536954	3	1	46	1	0	0	0	0	1	0	0	0	14145	1029	36	2	1482	2	SF1	11	64536954	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	398112	64536954	70469562	1031	12728										
MEN1	4221	broad.mit.edu	37	chr11	64571923	64571923	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttgcagcttgatggcgctCgagttgatcttggtggccac	14	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64571923C>T	uc001obj.2	-	10	1804	c.1731G>A	c.(1729-1731)TCG>TCA	p.S577S	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Silent_p.S577S|MEN1_uc001obl.2_Silent_p.S537S|MEN1_uc001obm.2_Silent_p.S572S|MEN1_uc001obn.2_Silent_p.S577S|MEN1_uc001obo.2_Silent_p.S577S|MEN1_uc001obp.2_Silent_p.S572S|MEN1_uc001obq.2_Silent_p.S577S|MEN1_uc001obr.2_Silent_p.S577S	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	577					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.S573_A574del(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						TGATGGCGCTCGAGTTGATCT	0.562			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	148	159										T	64571923	C	T	64571923	2	4	46	1	0	0	0	0	0	0	0	1	9472	871	31	1		1	MEN1	11	64571923	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	34969	64571923	70434593	1032	12729										
MEN1	4221	broad.mit.edu	37	chr11	64577195	64577195	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccttgaagtaggagcggctGaggctgttccatatgacatc	12	9	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64577195G>A	uc001obj.2	-	2	460	c.387C>T	c.(385-387)CTC>CTT	p.L129L	MEN1_uc001obk.2_Silent_p.L129L|MEN1_uc001obl.2_Silent_p.L129L|MEN1_uc001obm.2_Silent_p.L129L|MEN1_uc001obn.2_Silent_p.L129L|MEN1_uc001obo.2_Silent_p.L129L|MEN1_uc001obp.2_Silent_p.L129L|MEN1_uc001obq.2_Silent_p.L129L|MEN1_uc001obr.2_Silent_p.L129L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	129					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.I125fs*53(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						AGGAGCGGCTGAGGCTGTTCC	0.572			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	62	119										A	64577195	G	A	64577195	2	1	46	1	0	0	0	0	0	0	0	1	9472	1277	45	1		1	MEN1	11	64577195	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5272	64577195	70429321	1033	12730										
SLC25A45	283130	broad.mit.edu	37	chr11	65147003	65147003	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagctatgctggcaatgggGaagctcattcccttgaagaa	11	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65147003G>A	uc001odp.1	-	4	605	c.183C>T	c.(181-183)TTC>TTT	p.F61F	SLC25A45_uc009yqi.1_Intron|SLC25A45_uc001odq.1_Silent_p.F37F|SLC25A45_uc001odr.1_Silent_p.F61F|SLC25A45_uc001ods.1_Silent_p.F19F|SLC25A45_uc001odt.1_Silent_p.F19F	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	61	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TGGCAATGGGGAAGCTCATTC	0.622													0	0	0	0.004007	0	17	41										A	65147003	G	A	65147003	2	1	46	1	0	0	0	0	0	0	0	1	14510	1165	41	1		1	SLC25A45	11	65147003	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	569808	65147003	69859513	1034	12731										
FRMD8	83786	broad.mit.edu	37	chr11	65161130	65161130	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttcaccagtgccccagacGatgacgtggccatgggtcag	13	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65161130G>A	uc001odu.3	+	4	532	c.340G>A	c.(340-342)GAT>AAT	p.D114N	FRMD8_uc009yqj.2_Missense_Mutation_p.D58N|FRMD8_uc010rof.1_Intron	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	114	FERM.					cytoskeleton	binding			lung(1)|pancreas(1)	2						TGCCCCAGACGATGACGTGGC	0.652													0	0	0	0.000602	0	5	13										A	65161130	G	A	65161130	3	1	46	1	0	0	0	0	1	0	0	0	6056	1058	37	1	350	1	FRMD8	11	65161130	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14127	65161130	69845386	1035	12732										
PCNXL3	399909	broad.mit.edu	37	chr11	65401671	65401671	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagggcatcacggcagccctGaggcctgtgcgggtgcccgg	18	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65401671G>A	uc001oey.2	+	28	4545	c.4545G>A	c.(4543-4545)CTG>CTA	p.L1515L	PCNXL3_uc001oez.2_Silent_p.L402L	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1515						integral to membrane					0						CGGCAGCCCTGAGGCCTGTGC	0.642													0	0	0	0.001168	0	5	20										A	65401671	G	A	65401671	2	1	46	1	0	0	0	0	0	0	0	1	11593	1277	45	1		1	PCNXL3	11	65401671	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	240541	65401671	69604845	1036	12733										
GAL3ST3	89792	broad.mit.edu	37	chr11	65812872	65812872	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggcctgctgcaggcgctgGaggatgggtggcatggcgga	21	8	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65812872G>A	uc001ogv.2	-	1	175	c.15C>T	c.(13-15)CTC>CTT	p.L5L	GAL3ST3_uc001ogw.2_Silent_p.L5L	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	5	Cytoplasmic (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						GCAGGCGCTGGAGGATGGGTG	0.647											OREG0021093	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	36										A	65812872	G	A	65812872	2	1	46	1	0	0	0	0	0	0	0	1	6199	1161	41	1		1	GAL3ST3	11	65812872	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	411201	65812872	69193644	1037	12734										
RIN1	9610	broad.mit.edu	37	chr11	66099752	66099752	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctggccacttcaagctactCctctgctgcccggcttccct	7	18	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66099752C>G	uc001ohn.1	-	10	2474	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q	RIN1_uc010roy.1_Missense_Mutation_p.E414Q|RIN1_uc009yrd.1_Missense_Mutation_p.E476Q|RIN1_uc010roz.1_Missense_Mutation_p.E678Q|RIN1_uc010rpa.1_Missense_Mutation_p.E617Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	783					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						TCAAGCTACTCCTCTGCTGCC	0.632													0	0	0	0.01441	0	53	122										G	66099752	C	G	66099752	3	3	46	1	0	0	0	0	1	0	0	0	13371	864	30	1	8	1	RIN1	11	66099752	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	286880	66099752	68906764	1038	12735										
RIN1	9610	broad.mit.edu	37	chr11	66099842	66099842	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccccttcagcagttgtctCagactgttcccgaatgtccc	8	16	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66099842C>G	uc001ohn.1	-	10	2384	c.2257G>C	c.(2257-2259)GAG>CAG	p.E753Q	RIN1_uc010roy.1_Missense_Mutation_p.E384Q|RIN1_uc009yrd.1_Missense_Mutation_p.E446Q|RIN1_uc010roz.1_Missense_Mutation_p.E648Q|RIN1_uc010rpa.1_Missense_Mutation_p.E587Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	753					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						GCAGTTGTCTCAGACTGTTCC	0.632													0	0	0	0.01441	0	60	159										G	66099842	C	G	66099842	3	3	46	1	0	0	0	0	1	0	0	0	13371	835	29	1	98	1	RIN1	11	66099842	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	90	66099842	68906674	1039	12736										
NPAS4	266743	broad.mit.edu	37	chr11	66192561	66192561	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcaggggatcctgaggcaGagggcccaggaggggcccca	18	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66192561G>A	uc001ohx.1	+	7	2376	c.2200G>A	c.(2200-2202)GAG>AAG	p.E734K	NPAS4_uc010rpc.1_Missense_Mutation_p.E524K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	734					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TCCTGAGGCAGAGGGCCCAGG	0.577													0	0	0	0.007291	0	30	139										A	66192561	G	A	66192561	3	1	46	1	0	0	0	0	1	0	0	0	10565	943	33	1	2226	1	NPAS4	11	66192561	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	92719	66192561	68813955	1040	12737										
BBS1	582	broad.mit.edu	37	chr11	66291352	66291352	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcaatgtcatccacacccCggtgagccccatctccggca	8	18	3	1	rs141255069	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66291352C>G	uc001oij.1	+	11	1121	c.1109C>G	c.(1108-1110)CCG>CGG	p.P370R	BBS1_uc001oii.1_Missense_Mutation_p.P407R|BBS1_uc010rpg.1_Missense_Mutation_p.P273R|BBS1_uc001oik.1_Missense_Mutation_p.P294R|BBS1_uc001oil.1_Intron|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Missense_Mutation_p.P38R	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	370					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						ATCCACACCCCGGTGAGCCCC	0.587									Bardet-Biedl_syndrome				0	0	0	0.001984	0	6	57										G	66291352	C	G	66291352	3	3	46	1	0	0	0	0	1	0	0	0	1335	666	23	4	1151	4	BBS1	11	66291352	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	98791	66291352	68715164	1041	12738										
ADRBK1	156	broad.mit.edu	37	chr11	67051768	67051768	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggtggcagagactgtcttCgacaccatcaacgctgagac	12	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:67051768C>T	uc009yrn.1	+	18	1844	c.1578C>T	c.(1576-1578)TTC>TTT	p.F526F	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	526					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	AGACTGTCTTCGACACCATCA	0.602													0	0	0	0.00245	0	13	81										T	67051768	C	T	67051768	2	4	46	1	0	0	0	0	0	0	0	1	343	883	31	1		1	ADRBK1	11	67051768	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	760416	67051768	67954748	1042	12739										
SAPS3	55291	broad.mit.edu	37	chr11	68363635	68363635	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcaaagcaagacttgtttGaacccagcagtgccaacacg	10	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:68363635G>A	uc001onw.2	+	19	2254	c.1987G>A	c.(1987-1989)GAA>AAA	p.E663K	SAPS3_uc001onv.2_Missense_Mutation_p.E663K|SAPS3_uc001ony.3_Missense_Mutation_p.E634K|SAPS3_uc001onx.2_Missense_Mutation_p.E657K|SAPS3_uc009ysh.2_Missense_Mutation_p.E583K|SAPS3_uc001onu.2_Missense_Mutation_p.E583K|SAPS3_uc010rqc.1_Missense_Mutation_p.E431K|SAPS3_uc010rqd.1_Missense_Mutation_p.E346K|SAPS3_uc001onz.2_5'UTR|SAPS3_uc001ooa.2_Missense_Mutation_p.E113K	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	663					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			AGACTTGTTTGAACCCAGCAG	0.453													0	0	0	0.01441	0	51	50										A	68363635	G	A	68363635	3	1	46	1	0	0	0	0	1	0	0	0	13838	1291	45	1	2053	1	SAPS3	11	68363635	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1311867	68363635	66642881	1043	12740										
CPT1A	1374	broad.mit.edu	37	chr11	68527743	68527743	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgggttattctccaagtCaaacagctccacttgctgct	7	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:68527743C>G	uc001oog.3	-	17	2262	c.2092G>C	c.(2092-2094)GAC>CAC	p.D698H	CPT1A_uc001oof.3_Missense_Mutation_p.D698H|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	698	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TTCTCCAAGTCAAACAGCTCC	0.557													0	0	0	0.003163	0	16	16										G	68527743	C	G	68527743	3	3	46	1	0	0	0	0	1	0	0	0	3831	826	29	1	281	1	CPT1A	11	68527743	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	164108	68527743	66478773	1044	12741										
MRGPRD	116512	broad.mit.edu	37	chr11	68747724	68747724	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcggcaggctcaaccagtaGagcacaaaccagtagatgct	12	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:68747724G>A	uc010rqf.1	-	1	732	c.732C>T	c.(730-732)CTC>CTT	p.L244L		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	244	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCAACCAGTAGAGCACAAACC	0.612													0	0	0	0.008361	0	32	40										A	68747724	G	A	68747724	2	1	46	1	0	0	0	0	0	0	0	1	9763	929	33	1		1	MRGPRD	11	68747724	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	219981	68747724	66258792	1045	12742										
CCND1	595	broad.mit.edu	37	chr11	69458749	69458749	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgcagaccttcgttgccctCtgtgccacaggtagggcagg	14	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:69458749C>T	uc001opa.2	+	3	773	c.564C>T	c.(562-564)CTC>CTT	p.L188L		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	188				L -> S (in Ref. 3; AAA52136).	cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	TCGTTGCCCTCTGTGCCACAG	0.617			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			0	0	0	0.00245	0	14	12										T	69458749	C	T	69458749	2	4	46	1	0	0	0	0	0	0	0	1	2916	900	32	1		1	CCND1	11	69458749	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	711025	69458749	65547767	1046	12743										
C2CD3	26005	broad.mit.edu	37	chr11	73796738	73796738	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgctaggaaacaggcctCtccactacagtgctgagtca	9	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:73796738C>T	uc001ouu.2	-	21	4062	c.3835G>A	c.(3835-3837)GAG>AAG	p.E1279K	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1279	C2 1.					centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					AAACAGGCCTCTCCACTACAG	0.473													0	0	0	0.003163	0	16	34										T	73796738	C	T	73796738	3	4	46	1	0	0	0	0	1	0	0	0	2154	922	32	1	2100	1	C2CD3	11	73796738	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4337989	73796738	61209778	1047	12744										
OR2AT4	341152	broad.mit.edu	37	chr11	74800029	74800029	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggtgggagctgcaggtggAgaaggcttttgcccgtcctt	16	8	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:74800029A>G	uc010rro.1	-	1	730	c.730T>C	c.(730-732)TCC>CCC	p.S244P		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	244	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGCAGGTGGAGAAGGCTTTT	0.567													0	0	0	0.004007	0	14	20										G	74800029	A	G	74800029	3	3	46	1	0	0	0	0	1	0	0	0	10987	304	11	5	235	5	OR2AT4	11	74800029	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1003291	74800029	60206487	1048	12745										
C11orf30	56946	broad.mit.edu	37	chr11	76255317	76255317	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttaggcattaagcagtcaCactgcttttaccaaacacag	6	11	1	0	rs146751469		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:76255317C>T	uc001oxl.2	+	19	2867	c.2724C>T	c.(2722-2724)CAC>CAT	p.H908H	C11orf30_uc001oxm.2_Silent_p.H810H|C11orf30_uc010rsb.1_Silent_p.H923H|C11orf30_uc010rsc.1_Silent_p.H909H|C11orf30_uc001oxn.2_Silent_p.H909H|C11orf30_uc010rsd.1_Silent_p.H817H|C11orf30_uc001oxo.1_Silent_p.H262H|C11orf30_uc010rse.1_Silent_p.H155H|C11orf30_uc001oxp.2_Silent_p.H8H	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	908					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						TAAGCAGTCACACTGCTTTTA	0.403													0	0	0	0.00499	0	17	41										T	76255317	C	T	76255317	2	4	46	1	0	0	0	0	0	0	0	1	1636	477	17	2		2	C11orf30	11	76255317	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1455288	76255317	58751199	1049	12746										
AQP11	282679	broad.mit.edu	37	chr11	77301461	77301461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagcgccttgtggagcttgGgtctgacccagtatcacgtc	12	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:77301461G>A	uc001oyj.2	+	1	782	c.424G>A	c.(424-426)GGT>AGT	p.G142S	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	142						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GTGGAGCTTGGGTCTGACCCA	0.602													0	0	0	0.008871	0	20	29										A	77301461	G	A	77301461	3	1	46	1	0	0	0	0	1	0	0	0	823	1232	43	2	426	2	AQP11	11	77301461	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1046144	77301461	57705055	1050	12747										
AQP11	282679	broad.mit.edu	37	chr11	77301511	77301511	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcttcgcttgcaagaatccCatccgagtcgacttgctcaa	8	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:77301511C>T	uc001oyj.2	+	1	832	c.474C>T	c.(472-474)CCC>CCT	p.P158P	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	158						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GCAAGAATCCCATCCGAGTCG	0.567													0	0	0	0.004656	0	28	49										T	77301511	C	T	77301511	2	4	46	1	0	0	0	0	0	0	0	1	823	581	21	2		2	AQP11	11	77301511	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	50	77301511	57705005	1051	12748										
ODZ4	26011	broad.mit.edu	37	chr11	78399156	78399156	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttggtggttatggtgacatCatccttgctggaggtctcta	13	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:78399156C>T	uc001ozl.3	-	29	5666	c.5203G>A	c.(5203-5205)GAT>AAT	p.D1735N	ODZ4_uc009yvb.1_Missense_Mutation_p.D319N	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1735	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						ATGGTGACATCATCCTTGCTG	0.562													0	0	0	0.00333	0	25	78										T	78399156	C	T	78399156	3	4	46	1	0	0	0	0	1	0	0	0	10837	826	29	1	3130	1	ODZ4	11	78399156	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1097645	78399156	56607360	1052	12749										
C11orf82	220042	broad.mit.edu	37	chr11	82625788	82625788	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acggtgtgaacacatgaacaGaagacgaaaatttcttctag	9	7	2	4	rs142883872	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:82625788G>A	uc001ozt.2	+	3	252	c.8G>A	c.(7-9)AGA>AAA	p.R3K	C11orf82_uc010rsr.1_5'UTR|C11orf82_uc010rss.1_5'UTR|C11orf82_uc009yvd.2_Missense_Mutation_p.R3K	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	3					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						CACATGAACAGAAGACGAAAA	0.398													0	0	0	0.010729	0	10	52										A	82625788	G	A	82625788	3	1	46	1	0	0	0	0	1	0	0	0	1665	942	33	1	10	1	C11orf82	11	82625788	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4226632	82625788	52380728	1053	12750										
PCF11	51585	broad.mit.edu	37	chr11	82877677	82877677	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attctacaaagtcaggcactGaaccaaaggagaatgtagaa	9	7	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:82877677G>A	uc001ozx.3	+	5	2083	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K	PCF11_uc010rsu.1_Missense_Mutation_p.E580K	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	580					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GTCAGGCACTGAACCAAAGGA	0.388													0	0	0	0.006122	0	18	88										A	82877677	G	A	82877677	3	1	46	1	0	0	0	0	1	0	0	0	11573	1291	45	1	1756	1	PCF11	11	82877677	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	251889	82877677	52128839	1054	12751										
PCF11	51585	broad.mit.edu	37	chr11	82877695	82877695	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgaaccaaaggagaatgtaGaaaactggcaaagttccaag	10	7	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:82877695G>A	uc001ozx.3	+	5	2101	c.1756G>A	c.(1756-1758)GAA>AAA	p.E586K	PCF11_uc010rsu.1_Missense_Mutation_p.E586K	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	586					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GGAGAATGTAGAAAACTGGCA	0.393													0	0	0	0.01441	0	62	45										A	82877695	G	A	82877695	3	1	46	1	0	0	0	0	1	0	0	0	11573	943	33	1	1774	1	PCF11	11	82877695	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	18	82877695	52128821	1055	12752										
CCDC89	220388	broad.mit.edu	37	chr11	85396454	85396454	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctgctccacagcctgctgGtgctgctgcttgagggtctg	13	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:85396454G>A	uc001pau.1	-	1	867	c.720C>T	c.(718-720)CAC>CAT	p.H240H		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	240	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CAGCCTGCTGGTGCTGCTGCT	0.617													0	0	0	0.014323	0	19	107										A	85396454	G	A	85396454	2	1	46	1	0	0	0	0	0	0	0	1	2866	1252	44	2		2	CCDC89	11	85396454	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2518759	85396454	49610062	1056	12753										
C11orf73	51501	broad.mit.edu	37	chr11	86048553	86048553	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggtaatgctgctgtatcctCagttgactcattcactcagg	9	10	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:86048553C>T	uc001pbu.2	+	3	639	c.401C>T	c.(400-402)TCA>TTA	p.S134L	C11orf73_uc001pbt.2_Missense_Mutation_p.S134L|C11orf73_uc010rto.1_RNA|C11orf73_uc010rtp.1_Missense_Mutation_p.S35L|C11orf73_uc001pbv.2_RNA	NM_016401	NP_057485	Q53FT3	CK073_HUMAN	lethal, Chr 7, Rinchik 6	134						cytoplasm					0		Acute lymphoblastic leukemia(157;1.17e-07)|all_hematologic(158;0.000556)				GCTGTATCCTCAGTTGACTCA	0.338													0	0	0	0.01441	0	48	319										T	86048553	C	T	86048553	3	4	46	1	0	0	0	0	1	0	0	0	1661	838	29	1	411	1	C11orf73	11	86048553	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	652099	86048553	48957963	1057	12754										
HEPHL1	341208	broad.mit.edu	37	chr11	93796691	93796692	+	Missense_Mutation	DNP	GG	GG	AA													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggagccctatacccagatGgaacatctggaaggaacaaa							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:93796691_93796692GG>AA	uc001pep.2	+	3	590_591	c.433_434GG>AA	c.(433-435)GGA>AAA	p.G145K		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	145	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATACCCAGATGGAACATCTGGA	0.322													0	0	0	0.004672	0	6	7										AA	93796692	GG	AA	93796691	3	1	46	1	0	0	0	0	1	0	0	0	7055	1349	47	2	443	2	HEPHL1	11	93796691	Missense_Mutation	DNP	GG	TCGA-DK-A1AC-01A-11D-A13W-08	7748138	93796691	41209825	1058	12755										
HEPHL1	341208	broad.mit.edu	37	chr11	93808405	93808405	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catacaagtggacagtgcctGagagcgtaagcccaactgct	11	11	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:93808405G>A	uc001pep.2	+	9	1727	c.1570G>A	c.(1570-1572)GAG>AAG	p.E524K	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	524	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GACAGTGCCTGAGAGCGTAAG	0.468													0	0	0	0.013537	0	12	21										A	93808405	G	A	93808405	3	1	46	1	0	0	0	0	1	0	0	0	7055	1291	45	1	1604	1	HEPHL1	11	93808405	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	11714	93808405	41198111	1059	12756										
GPR83	10888	broad.mit.edu	37	chr11	94113882	94113882	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccaagtccaggtacttccaGaagaggtcagctggctcagg	13	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:94113882G>A	uc001pet.2	-	4	877	c.705C>T	c.(703-705)TTC>TTT	p.F235F		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	235	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGTACTTCCAGAAGAGGTCAG	0.587													0	0	0	0.000602	0	5	20										A	94113882	G	A	94113882	2	1	46	1	0	0	0	0	0	0	0	1	6713	933	33	1		1	GPR83	11	94113882	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	305477	94113882	40892634	1060	12757										
GPR83	10888	broad.mit.edu	37	chr11	94113903	94113903	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagaggtcagctggctcaggGaagtctggcaggcagaggga	18	7	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:94113903G>T	uc001pet.2	-	4	856	c.684C>A	c.(682-684)TTC>TTA	p.F228L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	228	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTGGCTCAGGGAAGTCTGGCA	0.572													1	0	5.9392e-07	0.001168	6.10519e-07	5	24										T	94113903	G	T	94113903	3	4	46	1	0	0	0	0	1	0	0	0	6713	1165	41	3	591	3	GPR83	11	94113903	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	21	94113903	40892613	1061	12758										
MMP12	4321	broad.mit.edu	37	chr11	102736603	102736603	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaagttaggaaaaccaaaaGaatgtatgctcttgggataa	9	5	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:102736603G>T	uc001phk.2	-	9	1154	c.1109C>A	c.(1108-1110)TCT>TAT	p.S370Y		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	370	Hemopexin-like 2.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AAAACCAAAAGAATGTATGCT	0.328													1	0	4.36969e-10	0.001855	4.54565e-10	13	24										T	102736603	G	T	102736603	3	4	46	1	0	0	0	0	1	0	0	0	9651	942	33	3	315	3	MMP12	11	102736603	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8622700	102736603	32269913	1062	12759										
CASP1	834	broad.mit.edu	37	chr11	104899926	104899926	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcatcatcctcaaactcttCtgtagttggtaaagataggt	8	8	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:104899926C>A	uc010rve.1	-	7	948	c.931G>T	c.(931-933)GAA>TAA	p.E311*	CASP1_uc001pig.2_Nonsense_Mutation_p.E218*|CASP1_uc001pik.2_Nonsense_Mutation_p.E274*|CASP1_uc010rvf.1_Nonsense_Mutation_p.E218*|CASP1_uc010rvg.1_Nonsense_Mutation_p.E290*|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Nonsense_Mutation_p.E311*|CASP1_uc009yxi.2_Nonsense_Mutation_p.E290*|CASP1_uc010rvj.1_Nonsense_Mutation_p.E311*|CASP1_uc009yxj.2_Nonsense_Mutation_p.E156*|CASP1_uc010rvk.1_Nonsense_Mutation_p.E272*	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	311					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TCAAACTCTTCTGTAGTTGGT	0.413													1	0	9.16793e-09	0.00499	9.49614e-09	16	40										A	104899926	C	A	104899926	4	1	46	1	0	0	0	0	0	1	0	0	2668	922	32	3	295	3	CASP1	11	104899926	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2163323	104899926	30106590	1063	12760										
GUCY1A2	2977	broad.mit.edu	37	chr11	106680837	106680837	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgtgaagccaacaatgtctGaaaagagcatggtgacatca	10	8	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:106680837G>A	uc001pjg.1	-	5	1964	c.1574C>T	c.(1573-1575)TCA>TTA	p.S525L	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S546L|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S525L	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	525	Guanylate cyclase.				intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AACAATGTCTGAAAAGAGCAT	0.453													0	0	0	0.006122	0	18	41										A	106680837	G	A	106680837	3	1	46	1	0	0	0	0	1	0	0	0	6893	1294	45	1	640	1	GUCY1A2	11	106680837	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1780911	106680837	28325679	1064	12761										
RAB39	54734	broad.mit.edu	37	chr11	107799300	107799300	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggggcacgtgagcgatggaGaccatctggatctaccagtt	14	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:107799300G>C	uc001pjt.2	+	1	24	c.6G>C	c.(4-6)GAG>GAC	p.E2D		NM_017516	NP_059986	Q14964	RB39A_HUMAN	RAB39, member RAS oncogene family	2					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0				BRCA - Breast invasive adenocarcinoma(274;3.04e-05)|Epithelial(105;8.56e-05)|all cancers(92;0.00179)		GAGCGATGGAGACCATCTGGA	0.632													0	0	0	0.009096	0	4	5										C	107799300	G	C	107799300	3	2	46	1	0	0	0	0	1	0	0	0	12929	933	33	1	8	1	RAB39	11	107799300	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1118463	107799300	27207216	1065	12762										
CUL5	8065	broad.mit.edu	37	chr11	107968457	107968457	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacagaaggtaccctcttctCagtgaaccaggagttcagtt	9	10	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:107968457C>T	uc001pjv.2	+	17	2667	c.2000C>T	c.(1999-2001)TCA>TTA	p.S667L	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	667					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		ACCCTCTTCTCAGTGAACCAG	0.348													0	0	0	0.00333	0	23	47										T	107968457	C	T	107968457	3	4	46	1	0	0	0	0	1	0	0	0	4059	838	29	1	2066	1	CUL5	11	107968457	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	169157	107968457	27038059	1066	12763										
PPP2R1B	5519	broad.mit.edu	37	chr11	111614220	111614220	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacttctgaactagtttcatGaggttgttggtggcagcttc	11	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:111614220G>A	uc001plx.1	-	12	1518	c.1434C>T	c.(1432-1434)CTC>CTT	p.L478L	PPP2R1B_uc001plw.1_Silent_p.L478L|PPP2R1B_uc010rwi.1_Silent_p.L414L|PPP2R1B_uc010rwj.1_Silent_p.L317L|PPP2R1B_uc010rwk.1_Silent_p.L433L|PPP2R1B_uc010rwl.1_Silent_p.L351L	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	478	HEAT 12.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		CTAGTTTCATGAGGTTGTTGG	0.383													0	0	0	0.01441	0	49	83										A	111614220	G	A	111614220	2	1	46	1	0	0	0	0	0	0	0	1	12383	1277	45	1		1	PPP2R1B	11	111614220	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3645763	111614220	23392296	1067	12764										
C11orf1	64776	broad.mit.edu	37	chr11	111753253	111753253	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctattcaaaccgtaccctGatgggcaactggaaccagga	9	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:111753253G>T	uc001pmd.2	+	2	544	c.207G>T	c.(205-207)CTG>CTT	p.L69L	C11orf1_uc001pme.2_Silent_p.L109L	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	69						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		ACCGTACCCTGATGGGCAACT	0.438													1	0	4.3838e-07	0.001855	4.5106e-07	13	16										T	111753253	G	T	111753253	2	4	46	1	0	0	0	0	0	0	0	1	1629	1277	45	3		3	C11orf1	11	111753253	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	139033	111753253	23253263	1068	12765										
CLDN25	644672	broad.mit.edu	37	chr11	113651192	113651192	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacctcatgctaagacctagGaacctggtcatctaggactg	9	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:113651192G>A	uc009yyw.1	+	1	675	c.675G>A	c.(673-675)AGG>AGA	p.R225R		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	225	Cytoplasmic (Potential).					integral to membrane|tight junction	structural molecule activity				0						TAAGACCTAGGAACCTGGTCA	0.498													0	0	0	0.010504	0	21	50										A	113651192	G	A	113651192	2	1	46	1	0	0	0	0	0	0	0	1	3485	1165	41	1		1	CLDN25	11	113651192	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1897939	113651192	21355324	1069	12766										
MLL	4297	broad.mit.edu	37	chr11	118348840	118348840	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcccggctgccaggtgcctGaggactgtggtgtttgtact	15	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:118348840G>A	uc001pta.2	+	5	3516	c.3493G>A	c.(3493-3495)GAG>AAG	p.E1165K	MLL_uc001ptb.2_Missense_Mutation_p.E1165K	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1165	CXXC-type.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CCAGGTGCCTGAGGACTGTGG	0.498			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.01441	0	50	96										A	118348840	G	A	118348840	3	1	46	1	0	0	0	0	1	0	0	0	9620	1291	45	1	3511	1	MLL	11	118348840	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4697648	118348840	16657676	1070	12767										
BCL9L	283149	broad.mit.edu	37	chr11	118773239	118773239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagggaccgttcccgatgctCcagctgctctttggacaagc	12	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:118773239C>T	uc001pug.2	-	6	2178	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	BCL9L_uc009zal.2_Missense_Mutation_p.E400K	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	405	Pro-rich.|Necessary for interaction with CTNNB1 (By similarity).				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCCCGATGCTCCAGCTGCTCT	0.687													0	0	0	0.00308	0	6	19										T	118773239	C	T	118773239	3	4	46	1	0	0	0	0	1	0	0	0	1382	864	30	1	3298	1	BCL9L	11	118773239	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	424399	118773239	16233277	1071	12768										
NLRX1	79671	broad.mit.edu	37	chr11	119044232	119044232	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctggctgagtggttcagcCggctgcccagggaggagcgc	17	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119044232C>G	uc001pvu.2	+	5	489	c.274C>G	c.(274-276)CGG>GGG	p.R92G	NLRX1_uc010rzc.1_5'UTR|NLRX1_uc001pvv.2_Missense_Mutation_p.R92G|NLRX1_uc001pvw.2_Missense_Mutation_p.R92G|NLRX1_uc001pvx.2_Missense_Mutation_p.R92G	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	92	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTGGTTCAGCCGGCTGCCCAG	0.587													0	0	0	0.004007	0	16	38										G	119044232	C	G	119044232	3	3	46	1	0	0	0	0	1	0	0	0	10485	643	23	4	288	4	NLRX1	11	119044232	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	270993	119044232	15962284	1072	12769										
NLRX1	79671	broad.mit.edu	37	chr11	119044292	119044292	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctagacacggtccacgttGaccctgtgatccgcgagagt	11	14	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119044292G>A	uc001pvu.2	+	5	549	c.334G>A	c.(334-336)GAC>AAC	p.D112N	NLRX1_uc010rzc.1_5'UTR|NLRX1_uc001pvv.2_Missense_Mutation_p.D112N|NLRX1_uc001pvw.2_Missense_Mutation_p.D112N|NLRX1_uc001pvx.2_Missense_Mutation_p.D112N	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	112	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGTCCACGTTGACCCTGTGAT	0.672													0	0	0	0.012319	0	22	30										A	119044292	G	A	119044292	3	1	46	1	0	0	0	0	1	0	0	0	10485	1290	45	1	348	1	NLRX1	11	119044292	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	60	119044292	15962224	1073	12770										
NLRX1	79671	broad.mit.edu	37	chr11	119050897	119050897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcagctgtgctgggcagcGgaaggcatgccctggatgag	18	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119050897G>A	uc001pvu.2	+	7	2382	c.2167G>A	c.(2167-2169)GGA>AGA	p.G723R	NLRX1_uc010rzc.1_Missense_Mutation_p.G545R|NLRX1_uc001pvv.2_Missense_Mutation_p.G723R|NLRX1_uc001pvw.2_Missense_Mutation_p.G723R|NLRX1_uc001pvx.2_Missense_Mutation_p.G723R	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	723	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCTGGGCAGCGGAAGGCATGC	0.637													0	0	0	0.00245	0	13	24										A	119050897	G	A	119050897	3	1	46	1	0	0	0	0	1	0	0	0	10485	1117	39	2	2189	2	NLRX1	11	119050897	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6605	119050897	15955619	1074	12771										
MCAM	4162	broad.mit.edu	37	chr11	119181552	119181552	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccagcaccgccaggaccagGatgcacacaatcacagccac	8	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119181552G>A	uc001pwf.2	-	14	1736	c.1707C>T	c.(1705-1707)ATC>ATT	p.I569I	MCAM_uc001pwg.1_RNA	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	569	Helical; (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CCAGGACCAGGATGCACACAA	0.617													0	0	0	0.012319	0	20	45										A	119181552	G	A	119181552	2	1	46	1	0	0	0	0	0	0	0	1	9368	1164	41	1		1	MCAM	11	119181552	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	130655	119181552	15824964	1075	12772										
TECTA	7007	broad.mit.edu	37	chr11	120989420	120989420	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccaaaggaagctatggaaGagtcaaggtgagcccctttc	11	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:120989420G>C	uc010rzo.1	+	6	1196	c.1196G>C	c.(1195-1197)AGA>ACA	p.R399T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	399	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGCTATGGAAGAGTCAAGGTG	0.507													0	0	0	0.008871	0	21	42										C	120989420	G	C	120989420	3	2	46	1	0	0	0	0	1	0	0	0	15744	942	33	1	1218	1	TECTA	11	120989420	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1807868	120989420	14017096	1076	12773										
SC5DL	6309	broad.mit.edu	37	chr11	121174160	121174160	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagccacatggccagaagatGacatcttccgacaagctatt	8	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:121174160G>C	uc001pxu.2	+	2	224	c.76G>C	c.(76-78)GAC>CAC	p.D26H	SC5DL_uc001pxs.1_Missense_Mutation_p.D26H|SC5DL_uc001pxt.2_Missense_Mutation_p.D26H|SC5DL_uc001pxv.2_Missense_Mutation_p.D26H	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	26					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		GCCAGAAGATGACATCTTCCG	0.383													0	0	0	0.010818	0	30	56										C	121174160	G	C	121174160	3	2	46	1	0	0	0	0	1	0	0	0	13866	1290	45	1	78	1	SC5DL	11	121174160	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	184740	121174160	13832356	1077	12774										
SORL1	6653	broad.mit.edu	37	chr11	121460047	121460047	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgtgcatcagtttgatttgGaagtgcgacgggatggatga	16	4	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:121460047G>A	uc001pxx.2	+	29	4106	c.4026G>A	c.(4024-4026)TGG>TGA	p.W1342*	SORL1_uc010rzp.1_Nonsense_Mutation_p.W188*|SORL1_uc010rzq.1_5'Flank	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1342	Extracellular (Potential).|LDL-receptor class A 7.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GTTTGATTTGGAAGTGCGACG	0.478													0	0	0	0.01441	0	53	113										A	121460047	G	A	121460047	4	1	46	1	0	0	0	0	0	1	0	0	14934	1183	41	1	4140	1	SORL1	11	121460047	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	285887	121460047	13546469	1078	12775										
DCPS	28960	broad.mit.edu	37	chr11	126215464	126215464	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcaccttcgccctcagggctGacgaccccctgctcaagctc	8	19	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:126215464G>A	uc001qdp.2	+	6	1299	c.970G>A	c.(970-972)GAC>AAC	p.D324N	uc001qdq.1_Intron	NM_014026	NP_054745	Q96C86	DCPS_HUMAN	mRNA decapping enzyme	324					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		CCTCAGGGCTGACGACCCCCT	0.607													0	0	0	0.013726	0	30	81										A	126215464	G	A	126215464	3	1	46	1	0	0	0	0	1	0	0	0	4301	1290	45	1	992	1	DCPS	11	126215464	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4755417	126215464	8791052	1079	12776										
KCNJ1	3758	broad.mit.edu	37	chr11	128709337	128709337	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taattcaaagtcctgctggaGaagggtctccgctgccatgt	11	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:128709337G>A	uc001qeo.1	-	2	910	c.859C>T	c.(859-861)CTC>TTC	p.L287F	KCNJ1_uc001qep.1_Missense_Mutation_p.L268F|KCNJ1_uc001qeq.1_Missense_Mutation_p.L268F|KCNJ1_uc001qer.1_Missense_Mutation_p.L268F|KCNJ1_uc001qes.1_Missense_Mutation_p.L268F	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	287	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TCCTGCTGGAGAAGGGTCTCC	0.483													0	0	0	0.01441	0	53	49										A	128709337	G	A	128709337	3	1	46	1	0	0	0	0	1	0	0	0	8043	942	33	1	320	1	KCNJ1	11	128709337	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2493873	128709337	6297179	1080	12777										
ARHGAP32	9743	broad.mit.edu	37	chr11	128936684	128936684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgagagctgggaaaatcttCggtcataaatacacagatga	10	7	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:128936684C>T	uc009zcp.2	-	6	569	c.569G>A	c.(568-570)CGA>CAA	p.R190Q	ARHGAP32_uc009zcq.1_Missense_Mutation_p.R150Q|ARHGAP32_uc001qfb.2_5'UTR	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	190	PX; atypical.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GGAAAATCTTCGGTCATAAAT	0.368													0	0	0	0.007413	0	20	28										T	128936684	C	T	128936684	3	4	46	1	0	0	0	0	1	0	0	0	881	884	31	1	5762	1	ARHGAP32	11	128936684	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	227347	128936684	6069832	1081	12778										
ADAMTS8	11095	broad.mit.edu	37	chr11	130278816	130278816	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcattatacttctcacactgCtgctccctgaagcttttccc	5	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:130278816C>G	uc001qgg.3	-	7	2128	c.1770G>C	c.(1768-1770)CAG>CAC	p.Q590H	ADAMTS8_uc001qgf.2_Missense_Mutation_p.Q71H	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	590	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCTCACACTGCTGCTCCCTGA	0.547													0	0	0	0.005443	0	27	85										G	130278816	C	G	130278816	3	3	46	1	0	0	0	0	1	0	0	0	272	796	28	4	911	4	ADAMTS8	11	130278816	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1342132	130278816	4727700	1082	12779										
SNX19	399979	broad.mit.edu	37	chr11	130785628	130785628	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgacctgaagccactccagcGaggctggagcccagccatcc	11	17	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:130785628G>A	uc001qgk.3	-	1	755	c.207C>T	c.(205-207)CTC>CTT	p.L69L	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.L69L|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	69					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCACTCCAGCGAGGCTGGAGC	0.602													0	0	0	0.004007	0	14	30										A	130785628	G	A	130785628	2	1	46	1	0	0	0	0	0	0	0	1	14890	1045	37	1		1	SNX19	11	130785628	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	506812	130785628	4220888	1083	12780										
JAM3	83700	broad.mit.edu	37	chr11	134014688	134014688	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacccctttttccccacagtGaagccagtgacccctgtctg	7	17	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:134014688G>A	uc001qhb.1	+	5	570	c.546G>A	c.(544-546)GTG>GTA	p.V182V	JAM3_uc009zcz.1_Silent_p.V131V	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	137	Extracellular (Potential).				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		TCCCCACAGTGAAGCCAGTGA	0.537													0	0	0	0.008871	0	19	48										A	134014688	G	A	134014688	2	1	46	1	0	0	0	0	0	0	0	1	7944	1304	45	1		1	JAM3	11	134014688	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3229060	134014688	991828	1084	12781										
GLB1L2	89944	broad.mit.edu	37	chr11	134214971	134214971	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agatcgggctgtgggtgattCtgcgtccaggcccctacatc	13	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:134214971C>A	uc001qhp.2	+	4	585	c.397C>A	c.(397-399)CTG>ATG	p.L133M	GLB1L2_uc009zdg.1_5'Flank	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	133					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		GTGGGTGATTCTGCGTCCAGG	0.637													1	0	0.00909568	0.009096	0.00921888	4	10										A	134214971	C	A	134214971	3	1	46	1	0	0	0	0	1	0	0	0	6429	912	32	3	411	3	GLB1L2	11	134214971	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	200283	134214971	791545	1085	12782										
B4GALNT3	283358	broad.mit.edu	37	chr12	662717	662717	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctgtgaagaacctgcctcAgatgagggggcccaggccca	13	14	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:662717A>G	uc001qii.1	+	14	1628	c.1628A>G	c.(1627-1629)CAG>CGG	p.Q543R	B4GALNT3_uc001qij.1_Missense_Mutation_p.Q446R|B4GALNT3_uc001qik.1_Missense_Mutation_p.Q92R	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	543	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			AACCTGCCTCAGATGAGGGGG	0.617													0	0	0	0.012319	0	23	13										G	662717	A	G	662717	3	3	46	1	0	0	0	0	1	0	0	0	1268	188	7	5	1682	5	B4GALNT3	12	662717	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08		662717	133189178	1086	12783										
FOXM1	2305	broad.mit.edu	37	chr12	2968485	2968485	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaccggctcctctccctcctCtccctgtgttgaatcacaag	7	17	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:2968485C>T	uc001qlf.2	-	9	1876	c.1611G>A	c.(1609-1611)GAG>GAA	p.E537E	uc001qld.2_Intron|FOXM1_uc001qle.2_Silent_p.E575E|FOXM1_uc001qlg.2_Silent_p.E522E|FOXM1_uc009zea.2_Silent_p.E522E|FOXM1_uc009zeb.2_Silent_p.E521E	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	537					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TCTCCCTCCTCTCCCTGTGTT	0.577													0	0	0	0.012213	0	30	49										T	2968485	C	T	2968485	2	4	46	1	0	0	0	0	0	0	0	1	6018	912	32	1		1	FOXM1	12	2968485	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2305768	2968485	130883410	1087	12784										
ANO2	57101	broad.mit.edu	37	chr12	5936945	5936945	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtccttacccatcgtgttGttggctcgggagcaggctgt	15	10	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:5936945G>C	uc001qnm.2	-	7	942	c.870C>G	c.(868-870)AAC>AAG	p.N290K		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	295	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CCATCGTGTTGTTGGCTCGGG	0.657													0	0	0	0.009096	0	3	4										C	5936945	G	C	5936945	3	2	46	1	0	0	0	0	1	0	0	0	697	1368	48	4	2206	4	ANO2	12	5936945	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2968460	5936945	127914950	1088	12785										
SCNN1A	6337	broad.mit.edu	37	chr12	6457910	6457910	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taccgtgacagagggagactCagaattggttttgtagttca	12	6	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:6457910C>T	uc001qnx.2	-	12	1901	c.1612G>A	c.(1612-1614)GAG>AAG	p.E538K	SCNN1A_uc001qnv.2_Missense_Mutation_p.E238K|SCNN1A_uc001qnw.2_Missense_Mutation_p.E597K|SCNN1A_uc010sfb.1_Missense_Mutation_p.E561K	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	538	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GAGGGAGACTCAGAATTGGTT	0.522													0	0	0	0.00278	0	25	42										T	6457910	C	T	6457910	3	4	46	1	0	0	0	0	1	0	0	0	13927	835	29	1	405	1	SCNN1A	12	6457910	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	520965	6457910	127393985	1089	12786										
CD4	920	broad.mit.edu	37	chr12	6926360	6926360	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctcccctaagctgatgctGagtttgaaactggagaacaa	9	10	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:6926360G>T	uc001qqv.1	+	7	1265	c.1020G>T	c.(1018-1020)CTG>CTT	p.L340L	CD4_uc010sfj.1_Silent_p.L67L|CD4_uc009zfc.1_Silent_p.L161L|CD4_uc010sfk.1_Silent_p.L67L|CD4_uc010sfl.1_Silent_p.L67L|CD4_uc010sfm.1_Silent_p.L67L	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	340	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				AGCTGATGCTGAGTTTGAAAC	0.567													1	0	1.12685e-05	0.004482	1.1518e-05	9	18										T	6926360	G	T	6926360	2	4	46	1	0	0	0	0	0	0	0	1	3014	1277	45	3		3	CD4	12	6926360	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	468450	6926360	126925535	1090	12787										
PHB2	11331	broad.mit.edu	37	chr12	7078670	7078670	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcagacctacctttggagcCtgtaggggaggagatttttc	12	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:7078670C>A	uc001qsd.2	-	3	493	c.283G>T	c.(283-285)GGC>TGC	p.G95C	PHB2_uc010sft.1_Missense_Mutation_p.G95C|PHB2_uc010sfu.1_Missense_Mutation_p.G95C|EMG1_uc009zfo.2_5'Flank|EMG1_uc001qsh.3_5'Flank|EMG1_uc010sfv.1_5'Flank	NM_001144831	NP_001138303	Q99623	PHB2_HUMAN	prohibitin 2 isoform 1	95					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						CCTTTGGAGCCTGTAGGGGAG	0.507													1	0	1.9806e-07	0.014323	2.04176e-07	19	48										A	7078670	C	A	7078670	3	1	46	1	0	0	0	0	1	0	0	0	11815	681	24	4	644	4	PHB2	12	7078670	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	152310	7078670	126773225	1091	12788										
A2ML1	144568	broad.mit.edu	37	chr12	8988871	8988871	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgccgaagtttaaggtgGaagtggtggaacccaaggag	16	6	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:8988871G>A	uc001quz.3	+	7	762	c.664G>A	c.(664-666)GAA>AAA	p.E222K		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	66						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GTTTAAGGTGGAAGTGGTGGA	0.448													0	0	0	0.010729	0	10	30										A	8988871	G	A	8988871	3	1	46	1	0	0	0	0	1	0	0	0	5	1175	41	1	690	1	A2ML1	12	8988871	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1910201	8988871	124863024	1092	12789										
CDKN1B	1027	broad.mit.edu	37	chr12	12871770	12871770	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcgcttagattcttctactCaaaacaaaagagccaacaga	6	10	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:12871770C>T	uc001rat.2	+	2	959	c.487C>T	c.(487-489)CAA>TAA	p.Q163*		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	163	Nuclear localization signal (Potential).				autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		TTCTTCTACTCAAAACAAAAG	0.448									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				0	0	0	0.01441	0	72	33										T	12871770	C	T	12871770	4	4	46	1	0	0	0	0	0	1	0	0	3159	827	29	1	493	1	CDKN1B	12	12871770	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3882899	12871770	120980125	1093	12790										
SLCO1C1	53919	broad.mit.edu	37	chr12	20864431	20864431	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttatggaaaaatcaaaatcCaaaataagtaacggtaagat	7	4	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:20864431C>A	uc001rej.3	+	6	871	c.516C>A	c.(514-516)TCC>TCA	p.S172S	SLCO1C1_uc010sii.1_Silent_p.S172S|SLCO1C1_uc010sij.1_Silent_p.S172S|SLCO1C1_uc009zip.2_Silent_p.S6S|SLCO1C1_uc001rei.2_Silent_p.S172S|SLCO1C1_uc010sik.1_Silent_p.S54S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	172	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AATCAAAATCCAAAATAAGTA	0.343													1	0	2.32416e-17	0.014323	2.45064e-17	23	39										A	20864431	C	A	20864431	2	1	46	1	0	0	0	0	0	0	0	1	14725	581	21	4		4	SLCO1C1	12	20864431	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7992661	20864431	112987464	1094	12791										
BHLHE41	79365	broad.mit.edu	37	chr12	26277470	26277470	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accttggtgtcgtctcgtttCatgctccttttgggtttaca	9	10	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:26277470C>T	uc001rhb.2	-	2	399	c.108G>A	c.(106-108)ATG>ATA	p.M36I		NM_030762	NP_110389	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix domain containing, class	36					cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CGTCTCGTTTCATGCTCCTTT	0.478													0	0	0	0.003755	0	35	19										T	26277470	C	T	26277470	3	4	46	1	0	0	0	0	1	0	0	0	1424	826	29	1	1356	1	BHLHE41	12	26277470	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5413039	26277470	107574425	1095	12792										
ITPR2	3709	broad.mit.edu	37	chr12	26943129	26943129	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttggcaaggtccccggcctCtgggtgcaccacacatctgt	12	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:26943129C>T	uc001rhg.2	-	2	541	c.124G>A	c.(124-126)GAG>AAG	p.E42K	ITPR2_uc001rhh.1_Intron|ITPR2_uc001rhi.1_Missense_Mutation_p.E42K	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	42	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCCCCGGCCTCTGGGTGCACC	0.408													0	0	0	0.00245	0	13	34										T	26943129	C	T	26943129	3	4	46	1	0	0	0	0	1	0	0	0	7921	922	32	1	8205	1	ITPR2	12	26943129	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	665659	26943129	106908766	1096	12793										
DDX11	1663	broad.mit.edu	37	chr12	31240903	31240903	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaggatgacctggaggaaGaacacataactaaggtaaca	11	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:31240903G>A	uc001rjt.1	+	6	921	c.670G>A	c.(670-672)GAA>AAA	p.E224K	DDX11_uc010sjw.1_Missense_Mutation_p.E224K|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.E224K|DDX11_uc001rjs.1_Missense_Mutation_p.E224K|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.E224K|DDX11_uc001rjw.1_Missense_Mutation_p.E198K|DDX11_uc001rjx.1_5'UTR|DDX11_uc009zjn.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	224	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CCTGGAGGAAGAACACATAAC	0.532										Multiple Myeloma(12;0.14)			0	0	0	0.000602	0	5	11										A	31240903	G	A	31240903	3	1	46	1	0	0	0	0	1	0	0	0	4343	943	33	1	688	1	DDX11	12	31240903	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4297774	31240903	102610992	1097	12794										
SYT10	341359	broad.mit.edu	37	chr12	33592424	33592424	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgcagagccttctggcacaGactgttcactccgtcctcct	9	15	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:33592424G>A	uc001rll.1	-	1	331	c.34C>T	c.(34-36)CTG>TTG	p.L12L	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	12	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTCTGGCACAGACTGTTCACT	0.552													0	0	0	0.01441	0	44	100										A	33592424	G	A	33592424	2	1	46	1	0	0	0	0	0	0	0	1	15463	933	33	1		1	SYT10	12	33592424	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2351521	33592424	100259471	1098	12795										
ABCD2	225	broad.mit.edu	37	chr12	39947845	39947845	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctagcttttgtttttcttCactcaatgtcaaacggatag	6	8	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:39947845C>T	uc001rmb.2	-	10	2518	c.2092G>A	c.(2092-2094)GAA>AAA	p.E698K		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	698	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TGTTTTTCTTCACTCAATGTC	0.383													0	0	0	0.009535	0	32	15										T	39947845	C	T	39947845	3	4	46	1	0	0	0	0	1	0	0	0	61	835	29	1	134	1	ABCD2	12	39947845	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6355421	39947845	93904050	1099	12796										
LRRK2	120892	broad.mit.edu	37	chr12	40749951	40749951	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcttttggttggaaccgctGatggcaagttagcaattttt	10	6	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:40749951G>A	uc001rmg.3	+	46	6926	c.6805G>A	c.(6805-6807)GAT>AAT	p.D2269N	LRRK2_uc009zjw.2_Missense_Mutation_p.D1107N|LRRK2_uc001rmi.2_Missense_Mutation_p.D1102N	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2269					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGGAACCGCTGATGGCAAGTT	0.224													0	0	0	0.001984	0	7	14										A	40749951	G	A	40749951	3	1	46	1	0	0	0	0	1	0	0	0	9033	1290	45	1	6987	1	LRRK2	12	40749951	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	802106	40749951	93101944	1100	12797										
ANO6	196527	broad.mit.edu	37	chr12	45781986	45781986	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagcgacgccaggcagaacTtgagtatgaatgggatactg	14	7	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:45781986T>C	uc001roo.2	+	11	1543	c.1208T>C	c.(1207-1209)CTT>CCT	p.L403P	ANO6_uc010sld.1_Missense_Mutation_p.L403P|ANO6_uc010sle.1_Missense_Mutation_p.L403P|ANO6_uc010slf.1_Missense_Mutation_p.L424P|ANO6_uc010slg.1_Missense_Mutation_p.L385P	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	403	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						CAGGCAGAACTTGAGTATGAA	0.423													0	0	0	0.01441	0	76	135										C	45781986	T	C	45781986	3	2	46	1	0	0	0	0	1	0	0	0	701	1609	56	5	1270	5	ANO6	12	45781986	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	5032035	45781986	88069909	1101	12798										
SLC38A1	81539	broad.mit.edu	37	chr12	46582754	46582754	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttctttttctcggcgggtttCagtggccttcgtcactactc	9	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:46582754C>T	uc001rpa.2	-	17	1721	c.1463G>A	c.(1462-1464)TGA>TAA	p.*488*	SLC38A1_uc001rpb.2_Silent_p.*488*|SLC38A1_uc001rpc.2_Silent_p.*488*|SLC38A1_uc001rpd.2_Silent_p.*488*|SLC38A1_uc001rpe.2_Silent_p.*488*	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	488					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CGGCGGGTTTCAGTGGCCTTC	0.507													0	0	0	0.008871	0	17	65										T	46582754	C	T	46582754	2	4	46	1	0	0	0	0	0	0	0	1	14601	837	29	1		1	SLC38A1	12	46582754	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	800768	46582754	87269141	1102	12799										
DDN	23109	broad.mit.edu	37	chr12	49391911	49391911	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggctgatgaagtgggcacctGagagttcccggggcctctct	15	11	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49391911G>A	uc001rsv.1	-	2	766	c.748C>T	c.(748-750)CAG>TAG	p.Q250*	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	250						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						GTGGGCACCTGAGAGTTCCCG	0.657													0	0	0	0.001855	0	14	69										A	49391911	G	A	49391911	4	1	46	1	0	0	0	0	0	1	0	0	4333	1299	45	1	1391	1	DDN	12	49391911	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2809157	49391911	84459984	1103	12800										
MLL2	8085	broad.mit.edu	37	chr12	49434778	49434778	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccccctaccccagggctctCaggcacagccaagttatcca	7	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49434778C>T	uc001rta.3	-	31	6775	c.6775G>A	c.(6775-6777)GAG>AAG	p.E2259K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2259	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAGGGCTCTCAGGCACAGCC	0.632			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.008871	0	16	34										T	49434778	C	T	49434778	3	4	46	1	0	0	0	0	1	0	0	0	9621	835	29	1	9934	1	MLL2	12	49434778	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	42867	49434778	84417117	1104	12801										
MLL2	8085	broad.mit.edu	37	chr12	49445264	49445264	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcccctcggaccgggggcaGagttgcggctcctcaggtag	17	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49445264G>C	uc001rta.3	-	10	2202	c.2202C>G	c.(2200-2202)CTC>CTG	p.L734L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	734	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACCGGGGGCAGAGTTGCGGCT	0.692			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.008291	0	4	23										C	49445264	G	C	49445264	2	2	46	1	0	0	0	0	0	0	0	1	9621	929	33	1		1	MLL2	12	49445264	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10486	49445264	84406631	1105	12802										
PRPH	5630	broad.mit.edu	37	chr12	49689233	49689233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcgacttctccatggccGaggccctcaaccaggagttc	10	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49689233G>A	uc001rtu.2	+	1	325	c.250G>A	c.(250-252)GAG>AAG	p.E84K		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	84	Head.						structural molecule activity				0						CTCCATGGCCGAGGCCCTCAA	0.682													0	0	0	0.001168	0	6	7										A	49689233	G	A	49689233	3	1	46	1	0	0	0	0	1	0	0	0	12576	1059	37	1	252	1	PRPH	12	49689233	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	243969	49689233	84162662	1106	12803										
PRPF40B	25766	broad.mit.edu	37	chr12	50036100	50036100	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgcagggaagctgcctttcGaagcatgctgaggcaggctg	16	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:50036100G>A	uc001rur.1	+	19	1965	c.1901G>A	c.(1900-1902)CGA>CAA	p.R634Q	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Missense_Mutation_p.R656Q|PRPF40B_uc001ruq.1_Missense_Mutation_p.R621Q|PRPF40B_uc001rus.1_Missense_Mutation_p.R577Q|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	634					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GCTGCCTTTCGAAGCATGCTG	0.642													0	0	0	0.01441	0	45	55										A	50036100	G	A	50036100	3	1	46	1	0	0	0	0	1	0	0	0	12572	1058	37	1	1975	1	PRPF40B	12	50036100	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	346867	50036100	83815795	1107	12804										
PRPF40B	25766	broad.mit.edu	37	chr12	50037941	50037941	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgagctggagaggcggcggcGgacactcctacagcagctgg	17	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:50037941G>A	uc001rur.1	+	25	2646	c.2582G>A	c.(2581-2583)CGG>CAG	p.R861Q	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001ruq.1_Missense_Mutation_p.R848Q|PRPF40B_uc001rus.1_Missense_Mutation_p.R803Q|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	861					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						AGGCGGCGGCGGACACTCCTA	0.597											OREG0021798	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	4	29										A	50037941	G	A	50037941	3	1	46	1	0	0	0	0	1	0	0	0	12572	1116	39	2	2680	2	PRPF40B	12	50037941	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1841	50037941	83813954	1108	12805										
DIP2B	57609	broad.mit.edu	37	chr12	51130885	51130885	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccggttggagactctcacCttggagaggtttgtaataat	13	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:51130885C>G	uc001rwv.2	+	35	4324	c.4168C>G	c.(4168-4170)CTT>GTT	p.L1390V	DIP2B_uc009zlt.2_Missense_Mutation_p.L820V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1390						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						AGACTCTCACCTTGGAGAGGT	0.358													0	0	0	0.00623	0	37	143										G	51130885	C	G	51130885	3	3	46	1	0	0	0	0	1	0	0	0	4528	681	24	4	4306	4	DIP2B	12	51130885	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1092944	51130885	82721010	1109	12806										
LETMD1	25875	broad.mit.edu	37	chr12	51450271	51450271	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggattggccagctgactgctCaggaagtaaaatcggtaaga	13	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:51450271C>T	uc001rxm.2	+	7	957	c.901C>T	c.(901-903)CAG>TAG	p.Q301*	LETMD1_uc010smz.1_Nonsense_Mutation_p.Q251*|LETMD1_uc010sna.1_Missense_Mutation_p.S138L|LETMD1_uc001rxl.2_Nonsense_Mutation_p.Q245*|LETMD1_uc009zlv.2_RNA|LETMD1_uc001rxs.2_Missense_Mutation_p.S138L|LETMD1_uc009zlw.2_Nonsense_Mutation_p.Q314*|LETMD1_uc001rxn.2_Nonsense_Mutation_p.Q144*|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Nonsense_Mutation_p.Q184*|LETMD1_uc001rxq.2_Nonsense_Mutation_p.Q177*|LETMD1_uc001rxr.2_RNA|LETMD1_uc001rxt.2_Nonsense_Mutation_p.Q41*	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	301	Mitochondrial intermembrane (Potential).|LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						GCTGACTGCTCAGGAAGTAAA	0.507													0	0	0	0.007291	0	29	81										T	51450271	C	T	51450271	4	4	46	1	0	0	0	0	0	1	0	0	8736	827	29	1	927	1	LETMD1	12	51450271	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	319386	51450271	82401624	1110	12807										
POU6F1	5463	broad.mit.edu	37	chr12	51584140	51584140	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgagctccttagcaatttCagtgatctcctggcctgtgg	11	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:51584140C>T	uc001rxy.2	-	5	988	c.796G>A	c.(796-798)GAA>AAA	p.E266K	POU6F1_uc001rxz.2_Missense_Mutation_p.E266K|POU6F1_uc001rya.2_Missense_Mutation_p.E266K	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	266	Homeobox.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTAGCAATTTCAGTGATCTCC	0.547													0	0	0	0.013726	0	35	134										T	51584140	C	T	51584140	3	4	46	1	0	0	0	0	1	0	0	0	12284	835	29	1	113	1	POU6F1	12	51584140	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	133869	51584140	82267755	1111	12808										
KRT75	9119	broad.mit.edu	37	chr12	52827960	52827960	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atccttcccaggcccccactCcctgctgcagagcgggccac	9	20	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:52827960C>G	uc001saj.2	-	1	151	c.129G>C	c.(127-129)GGG>GGC	p.G43G		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	43	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GGCCCCCACTCCCTGCTGCAG	0.672													0	0	0	0.004482	0	6	48										G	52827960	C	G	52827960	2	3	46	1	0	0	0	0	0	0	0	1	8488	842	30	1		1	KRT75	12	52827960	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1243820	52827960	81023935	1112	12809										
KRT3	3850	broad.mit.edu	37	chr12	53185189	53185189	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgctgctcggcctcggcaaTggccgtctgcaggttggcat	14	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53185189T>C	uc001say.2	-	7	1402	c.1336A>G	c.(1336-1338)ATT>GTT	p.I446V		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	446	Rod.|Coil 2.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						GCCTCGGCAATGGCCGTCTGC	0.592													0	0	0	0.003755	0	32	42										C	53185189	T	C	53185189	3	2	46	1	0	0	0	0	1	0	0	0	8466	1464	51	5	562	5	KRT3	12	53185189	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	357229	53185189	80666706	1113	12810										
CSAD	51380	broad.mit.edu	37	chr12	53565116	53565116	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcctcttccccacctccttCgatgtgaatagggccagggg	11	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53565116C>G	uc001sby.2	-	7	687	c.561G>C	c.(559-561)TCG>TCC	p.S187S	CSAD_uc001sbw.2_Intron|CSAD_uc009zmt.2_Intron|CSAD_uc010snx.1_Silent_p.S214S|CSAD_uc001sbz.2_Silent_p.S187S|CSAD_uc009zmu.2_Intron|CSAD_uc001sca.3_RNA|CSAD_uc010sny.1_3'UTR	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	187					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CCACCTCCTTCGATGTGAATA	0.587									Hereditary_Prostate_Cancer				0	0	0	0.004878	0	35	59										G	53565116	C	G	53565116	2	3	46	1	0	0	0	0	0	0	0	1	3925	871	31	1		1	CSAD	12	53565116	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	379927	53565116	80286779	1114	12811										
RARG	5916	broad.mit.edu	37	chr12	53607344	53607344	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatccatctccaggggcagGagctgcccagcaaaggcaaa	11	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53607344G>A	uc001sce.2	-	8	1439	c.954C>T	c.(952-954)CTC>CTT	p.L318L	RARG_uc001scd.2_Silent_p.L307L|RARG_uc010sob.1_Silent_p.L296L|RARG_uc001scf.2_Silent_p.L318L|RARG_uc001scg.2_Silent_p.L246L|RARG_uc010soc.1_Silent_p.L197L|RARG_uc010sod.1_Silent_p.L355L	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	318	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CCAGGGGCAGGAGCTGCCCAG	0.652											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	24	27										A	53607344	G	A	53607344	2	1	46	1	0	0	0	0	0	0	0	1	13054	1161	41	1		1	RARG	12	53607344	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	42228	53607344	80244551	1115	12812										
RARG	5916	broad.mit.edu	37	chr12	53609125	53609125	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttctgtagccggcagtactGgcagcgattcctggtcacct	11	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53609125G>A	uc001sce.2	-	5	912	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	RARG_uc001scd.2_Nonsense_Mutation_p.Q132*|RARG_uc010sob.1_Nonsense_Mutation_p.Q121*|RARG_uc001scf.2_Nonsense_Mutation_p.Q143*|RARG_uc001scg.2_Nonsense_Mutation_p.Q71*|RARG_uc010soc.1_Nonsense_Mutation_p.Q22*|RARG_uc010sod.1_Nonsense_Mutation_p.Q180*	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	143	NR C4-type.|Nuclear receptor.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CGGCAGTACTGGCAGCGATTC	0.547													0	0	0	0.004289	0	32	81										A	53609125	G	A	53609125	4	1	46	1	0	0	0	0	0	1	0	0	13054	1357	47	2	961	2	RARG	12	53609125	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1781	53609125	80242770	1116	12813										
SP1	6667	broad.mit.edu	37	chr12	53776403	53776403	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgaggaagtggaggcaacatCattgctgctatgccaaacct	11	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53776403C>T	uc001scw.2	+	3	769	c.672C>T	c.(670-672)ATC>ATT	p.I224I	SP1_uc010sog.1_Silent_p.I217I	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	224	Transactivation domain A (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GAGGCAACATCATTGCTGCTA	0.502													0	0	0	0.01441	0	52	84										T	53776403	C	T	53776403	2	4	46	1	0	0	0	0	0	0	0	1	14959	816	29	1		1	SP1	12	53776403	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	167278	53776403	80075492	1117	12814										
OR6C2	341416	broad.mit.edu	37	chr12	55846762	55846762	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctatggaagctgcatcttCatctatatcaagccctctgc	7	13	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:55846762C>T	uc001sgz.1	+	1	765	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCTGCATCTTCATCTATATCA	0.423													0	0	0	0.009535	0	32	167										T	55846762	C	T	55846762	2	4	46	1	0	0	0	0	0	0	0	1	11191	825	29	1		1	OR6C2	12	55846762	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2070359	55846762	78005133	1118	12815										
SUOX	6821	broad.mit.edu	37	chr12	56397731	56397731	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgtacgtcacccagccctGaaggtcaacagccagcggcc	10	17	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56397731G>C	uc001six.2	+	6	884	c.558G>C	c.(556-558)CTG>CTC	p.L186L	SUOX_uc001siy.2_Silent_p.L186L|SUOX_uc001siz.2_Silent_p.L186L|SUOX_uc001sja.2_Silent_p.L186L	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	186	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			ACCCAGCCCTGAAGGTCAACA	0.547													0	0	0	0.003954	0	25	24										C	56397731	G	C	56397731	2	2	46	1	0	0	0	0	0	0	0	1	15392	1277	45	1		1	SUOX	12	56397731	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	550969	56397731	77454164	1119	12816										
ESYT1	23344	broad.mit.edu	37	chr12	56531079	56531079	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttgggacgtggacagtgaGaatccccagagaggcagcag	16	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56531079G>A	uc001sjq.2	+	17	1910	c.1860G>A	c.(1858-1860)GAG>GAA	p.E620E	ESYT1_uc001sjr.2_Silent_p.E630E	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	620						integral to membrane				ovary(4)|skin(1)	5						TGGACAGTGAGAATCCCCAGA	0.532													0	0	0	0.00623	0	34	59										A	56531079	G	A	56531079	2	1	46	1	0	0	0	0	0	0	0	1	5264	933	33	1		1	ESYT1	12	56531079	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	133348	56531079	77320816	1120	12817										
ANKRD52	283373	broad.mit.edu	37	chr12	56651667	56651667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacgcacttcctccacatctCggctaaagatggcctggacc	8	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56651667C>T	uc001skm.3	-	2	146	c.56G>A	c.(55-57)CGA>CAA	p.R19Q	ANKRD52_uc001skn.1_5'Flank	NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	19	ANK 1.						protein binding			ovary(2)	2						CTCCACATCTCGGCTAAAGAT	0.637													0	0	0	0.013537	0	13	23										T	56651667	C	T	56651667	3	4	46	1	0	0	0	0	1	0	0	0	678	884	31	1	3282	1	ANKRD52	12	56651667	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	120588	56651667	77200228	1121	12818										
PAN2	9924	broad.mit.edu	37	chr12	56716974	56716974	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggacacaccagcacaccctCtggactccctagttccttcc	7	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56716974C>T	uc001skx.2	-	17	2750	c.2377G>A	c.(2377-2379)GAG>AAG	p.E793K	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Missense_Mutation_p.E792K|PAN2_uc001sky.2_Missense_Mutation_p.E789K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	793					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						AGCACACCCTCTGGACTCCCT	0.463													0	0	0	0.01441	0	100	150										T	56716974	C	T	56716974	3	4	46	1	0	0	0	0	1	0	0	0	11414	922	32	1	1271	1	PAN2	12	56716974	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	65307	56716974	77134921	1122	12819										
PAN2	9924	broad.mit.edu	37	chr12	56720504	56720504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcaggtcctggctccagtCcagaggaggcagtgagtcca	14	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56720504C>T	uc001skx.2	-	7	1532	c.1159G>A	c.(1159-1161)GAC>AAC	p.D387N	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.D387N|PAN2_uc001sky.2_Missense_Mutation_p.D387N	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	387					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGGCTCCAGTCCAGAGGAGGC	0.587													0	0	0	0.00308	0	7	64										T	56720504	C	T	56720504	3	4	46	1	0	0	0	0	1	0	0	0	11414	855	30	1	2529	1	PAN2	12	56720504	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3530	56720504	77131391	1123	12820										
PAN2	9924	broad.mit.edu	37	chr12	56720612	56720612	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccagaggtgcacacagccctCagaatccccaaaggccagag	10	15	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56720612C>T	uc001skx.2	-	7	1424	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.E351K|PAN2_uc001sky.2_Missense_Mutation_p.E351K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	351					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ACACAGCCCTCAGAATCCCCA	0.562													0	0	0	0.007291	0	28	115										T	56720612	C	T	56720612	3	4	46	1	0	0	0	0	1	0	0	0	11414	835	29	1	2637	1	PAN2	12	56720612	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	108	56720612	77131283	1124	12821										
PAN2	9924	broad.mit.edu	37	chr12	56722297	56722297	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccccacgggccatatacttGaggttgttcttggtgagaaa	11	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56722297G>A	uc001skx.2	-	3	784	c.411C>T	c.(409-411)CTC>CTT	p.L137L	PAN2_uc001skz.2_Silent_p.L137L|PAN2_uc001sky.2_Silent_p.L137L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	137					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CCATATACTTGAGGTTGTTCT	0.488													0	0	0	0.01441	0	54	120										A	56722297	G	A	56722297	2	1	46	1	0	0	0	0	0	0	0	1	11414	1277	45	1		1	PAN2	12	56722297	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1685	56722297	77129598	1125	12822										
NACA	4666	broad.mit.edu	37	chr12	57108199	57108199	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctttactgactggttcttCatcaatttcagctgctgccg	8	11	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57108199C>T	uc001slz.2	-	4	530	c.181G>A	c.(181-183)GAA>AAA	p.E61K	NACA_uc001sly.2_Missense_Mutation_p.E61K|NACA_uc009zoy.1_Missense_Mutation_p.E1924K|NACA_uc001smc.2_Missense_Mutation_p.E61K|NACA_uc001sma.2_Missense_Mutation_p.E771K|NACA_uc001smb.2_Missense_Mutation_p.E61K|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	61					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						ACTGGTTCTTCATCAATTTCA	0.398			T	BCL6	NHL								0	0	0	0.010504	0	22	78										T	57108199	C	T	57108199	3	4	46	1	0	0	0	0	1	0	0	0	10133	835	29	1	486	1	NACA	12	57108199	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	385902	57108199	76743696	1126	12823										
SDR9C7	121214	broad.mit.edu	37	chr12	57328012	57328012	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attgcagttcttgaaccagcGatacataaatgagaggtctg	10	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57328012G>A	uc010sqw.1	-	1	34	c.34C>T	c.(34-36)CGC>TGC	p.R12C		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	12						cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						TTGAACCAGCGATACATAAAT	0.547													0	0	0	0.006214	0	10	52										A	57328012	G	A	57328012	3	1	46	1	0	0	0	0	1	0	0	0	13974	1058	37	1	923	1	SDR9C7	12	57328012	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	219813	57328012	76523883	1127	12824										
STAT6	6778	broad.mit.edu	37	chr12	57493598	57493598	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtgatgcccccaatctctgAgtcgctgaagcggaggagaa	14	10	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57493598A>T	uc009zpe.2	-	15	1947	c.1696T>A	c.(1696-1698)TCA>ACA	p.S566T	STAT6_uc009zpf.2_Missense_Mutation_p.S566T|STAT6_uc001sna.2_Missense_Mutation_p.S566T|STAT6_uc010srb.1_Missense_Mutation_p.S456T|STAT6_uc010src.1_Missense_Mutation_p.S456T|STAT6_uc010srd.1_Missense_Mutation_p.S456T|STAT6_uc009zpg.2_Missense_Mutation_p.S615T	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	566	SH2.				regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						CCAATCTCTGAGTCGCTGAAG	0.582													0	0	0	0.001855	0	11	23										T	57493598	A	T	57493598	3	4	46	1	0	0	0	0	1	0	0	0	15269	304	11	5	879	5	STAT6	12	57493598	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	165586	57493598	76358297	1128	12825										
INHBE	83729	broad.mit.edu	37	chr12	57850047	57850047	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcgccaagggtcccgcactCtcctggctgagcaccacatc	11	17	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57850047C>T	uc001snw.2	+	2	693	c.469C>T	c.(469-471)CTC>TTC	p.L157F		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	157					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						GTCCCGCACTCTCCTGGCTGA	0.602											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	102	177										T	57850047	C	T	57850047	3	4	46	1	0	0	0	0	1	0	0	0	7744	913	32	1	475	1	INHBE	12	57850047	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	356449	57850047	76001848	1129	12826										
GLI1	2735	broad.mit.edu	37	chr12	57858641	57858641	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctacggtcatctctccattGgcaccatgaggtgcagtcag	10	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57858641G>A	uc001snx.2	+	4	457	c.379G>A	c.(379-381)GGC>AGC	p.G127S	GLI1_uc009zpp.2_RNA|GLI1_uc009zpq.2_5'UTR|GLI1_uc009zpr.1_RNA	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	127					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TCTCTCCATTGGCACCATGAG	0.557													0	0	0	0.003163	0	15	57										A	57858641	G	A	57858641	3	1	46	1	0	0	0	0	1	0	0	0	6437	1348	47	2	389	2	GLI1	12	57858641	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8594	57858641	75993254	1130	12827										
DCTN2	10540	broad.mit.edu	37	chr12	57926780	57926780	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aactcaccatgagacaggctCcctgtagacctgcagaaagg	10	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57926780C>T	uc001som.1	-	9	893	c.761G>A	c.(760-762)GGA>GAA	p.G254E	DCTN2_uc009zpu.1_Missense_Mutation_p.G259E|DCTN2_uc009zpv.1_Missense_Mutation_p.G167E|DCTN2_uc009zpw.1_Missense_Mutation_p.G167E|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Missense_Mutation_p.G167E|DCTN2_uc001sop.1_Missense_Mutation_p.G167E|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Missense_Mutation_p.G254E	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	254					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						GAGACAGGCTCCCTGTAGACC	0.458													0	0	0	0.00308	0	8	17										T	57926780	C	T	57926780	3	4	46	1	0	0	0	0	1	0	0	0	4307	855	30	1	468	1	DCTN2	12	57926780	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	68139	57926780	75925115	1131	12828										
PIP4K2C	79837	broad.mit.edu	37	chr12	57994197	57994197	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggagaagaaaatatttctgGagaagctgaagagagatgtg	14	2	1	6			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57994197G>C	uc001sou.2	+	7	921	c.790G>C	c.(790-792)GAG>CAG	p.E264Q	PIP4K2C_uc001sot.2_Missense_Mutation_p.E264Q|PIP4K2C_uc010srs.1_Missense_Mutation_p.E246Q|PIP4K2C_uc010srt.1_Missense_Mutation_p.E216Q	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	264	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					AATATTTCTGGAGAAGCTGAA	0.403													0	0	0	0.013537	0	13	46										C	57994197	G	C	57994197	3	2	46	1	0	0	0	0	1	0	0	0	11938	1175	41	1	816	1	PIP4K2C	12	57994197	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	67417	57994197	75857698	1132	12829										
AGAP2	116986	broad.mit.edu	37	chr12	58127921	58127921	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgttctcatcctccaggctGaagacgaagatcacagcatc	8	13	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:58127921G>A	uc001spq.2	-	5	1437	c.1437C>T	c.(1435-1437)TTC>TTT	p.F479F	AGAP2_uc001spp.2_Silent_p.F479F|AGAP2_uc001spr.2_Silent_p.F143F	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	479	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						CCTCCAGGCTGAAGACGAAGA	0.587													0	0	0	0.010504	0	20	19										A	58127921	G	A	58127921	2	1	46	1	0	0	0	0	0	0	0	1	368	1281	45	1		1	AGAP2	12	58127921	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	133724	58127921	75723974	1133	12830										
MARCH9	92979	broad.mit.edu	37	chr12	58152013	58152013	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcactcagcccttcagccaaGtggcaacgacaggatctgct	9	14	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:58152013G>T	uc001spx.1	+	3	1048	c.636G>T	c.(634-636)AAG>AAT	p.K212N	MARCH9_uc001spy.2_Missense_Mutation_p.K99N	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	212						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CTTCAGCCAAGTGGCAACGAC	0.542													1	0	1.96895e-08	0.00278	2.03555e-08	23	62										T	58152013	G	T	58152013	3	4	46	1	0	0	0	0	1	0	0	0	9308	1020	36	4	646	4	MARCH9	12	58152013	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	24092	58152013	75699882	1134	12831										
AVIL	10677	broad.mit.edu	37	chr12	58191766	58191783	+	Splice_Site	DEL	CAGAGAGGTAATTCTAAG	CAGAGAGGTAATTCTAAG	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacagacacaaagtcctgttCagagaggtaattctaagaga							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:58191766_58191783delCAGAGAGGTAATTCTAAG	uc001sqj.1	-	19	2376	c.2347_splice	c.e19-1	p.N783_splice	AVIL_uc009zqe.1_Splice_Site_p.N776_splice	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin						actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					AAGTCCTGTTCAGAGAGGTAATTCTAAGAGAGAAAACA	0.436																		20	57	---	---								-	58191783	CAGAGAGGTAATTCTAAG	-	58191766	8	5	46	1	0	1	0	1	0	0	1	0	1227	835	29	0	104	0	AVIL	12	58191766	Splice_Site	DEL	CAGAGAGGTAATTCTAAG	TCGA-DK-A1AC-01A-11D-A13W-08	39753	58191766	75660129	1135	12832										
MON2	23041	broad.mit.edu	37	chr12	62861092	62861092	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagaagaaattcccacctgtCaaagaggtaagcttcaggtg	10	8	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:62861092C>T	uc001sre.2	+	1	496	c.105C>T	c.(103-105)GTC>GTT	p.V35V	MON2_uc009zqj.2_Silent_p.V35V|MON2_uc010ssl.1_5'UTR|MON2_uc010ssm.1_Silent_p.V35V|MON2_uc010ssn.1_Silent_p.V35V|MON2_uc001srd.1_Silent_p.V35V	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	35					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCCCACCTGTCAAAGAGGTAA	0.542													0	0	0	0.008871	0	20	70										T	62861092	C	T	62861092	2	4	46	1	0	0	0	0	0	0	0	1	9700	813	29	1		1	MON2	12	62861092	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4669326	62861092	70990803	1136	12833										
LEMD3	23592	broad.mit.edu	37	chr12	65564632	65564632	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtgcggcggtggccgcctCtagttcactcaggatcaatc	12	13	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:65564632C>T	uc001ssl.1	+	1	1262	c.1256C>T	c.(1255-1257)TCT>TTT	p.S419F	LEMD3_uc009zqo.1_Missense_Mutation_p.S419F	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	419					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GTGGCCGCCTCTAGTTCACTC	0.502													0	0	0	0.010504	0	20	65										T	65564632	C	T	65564632	3	4	46	1	0	0	0	0	1	0	0	0	8721	913	32	1	1258	1	LEMD3	12	65564632	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2703540	65564632	68287263	1137	12834										
KCNMB4	27345	broad.mit.edu	37	chr12	70760748	70760748	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtggcgccgactgcaggggCacctcgcagtacccctgcgt	14	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:70760748C>T	uc001svx.2	+	1	687	c.234C>T	c.(232-234)GGC>GGT	p.G78G		NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4	78	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			ACTGCAGGGGCACCTCGCAGT	0.627													0	0	0	0.014323	0	23	78										T	70760748	C	T	70760748	2	4	46	1	0	0	0	0	0	0	0	1	8077	697	25	2		2	KCNMB4	12	70760748	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5196116	70760748	63091147	1138	12835										
OSBPL8	114882	broad.mit.edu	37	chr12	76788453	76788453	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctgaagtagctcggatgatCaaataactgctaggtaaggg	12	6	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:76788453C>T	uc001sye.1	-	9	1209	c.729G>A	c.(727-729)TTG>TTA	p.L243L	OSBPL8_uc001syf.1_Silent_p.L201L|OSBPL8_uc001syg.1_Silent_p.L201L|OSBPL8_uc001syh.1_Silent_p.L218L	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	243	PH.				lipid transport		lipid binding			ovary(1)	1						CTCGGATGATCAAATAACTGC	0.323													0	0	0	0.003271	0	31	39										T	76788453	C	T	76788453	2	4	46	1	0	0	0	0	0	0	0	1	11283	825	29	1		1	OSBPL8	12	76788453	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6027705	76788453	57063442	1139	12836										
NAV3	89795	broad.mit.edu	37	chr12	78513043	78513043	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgatgatgccaaagcttctGagaaaggaaaagctccccta	9	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:78513043G>C	uc001syp.2	+	15	3240	c.3067G>C	c.(3067-3069)GAG>CAG	p.E1023Q	NAV3_uc001syo.2_Missense_Mutation_p.E1023Q|NAV3_uc010sub.1_Missense_Mutation_p.E523Q|NAV3_uc009zsf.2_Missense_Mutation_p.E31Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1023						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAAAGCTTCTGAGAAAGGAAA	0.418										HNSCC(70;0.22)			0	0	0	0.010771	0	42	211										C	78513043	G	C	78513043	3	2	46	1	0	0	0	0	1	0	0	0	10185	1291	45	1	3125	1	NAV3	12	78513043	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1724590	78513043	55338852	1140	12837										
NAV3	89795	broad.mit.edu	37	chr12	78513245	78513245	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcaaccataacaagtggctCtgcaacactgggtaaaattc	8	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:78513245C>T	uc001syp.2	+	15	3442	c.3269C>T	c.(3268-3270)TCT>TTT	p.S1090F	NAV3_uc001syo.2_Missense_Mutation_p.S1090F|NAV3_uc010sub.1_Missense_Mutation_p.S590F|NAV3_uc009zsf.2_Missense_Mutation_p.S98F	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1090	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACAAGTGGCTCTGCAACACTG	0.483										HNSCC(70;0.22)			0	0	0	0.004007	0	13	62										T	78513245	C	T	78513245	3	4	46	1	0	0	0	0	1	0	0	0	10185	913	32	1	3327	1	NAV3	12	78513245	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	202	78513245	55338650	1141	12838										
ACSS3	79611	broad.mit.edu	37	chr12	81536974	81536974	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgactgtgttcctgttctttCagaacacccactgtatattc	6	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:81536974C>T	uc001szl.1	+	5	960	c.869C>T	c.(868-870)TCA>TTA	p.S290L	ACSS3_uc001szm.1_Missense_Mutation_p.S289L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	290						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTGTTCTTTCAGAACACCCA	0.453													0	0	0	0.01441	0	97	20										T	81536974	C	T	81536974	3	4	46	1	0	0	0	0	1	0	0	0	190	838	29	1	887	1	ACSS3	12	81536974	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3023729	81536974	52314921	1142	12839										
KERA	11081	broad.mit.edu	37	chr12	91445283	91445283	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgggctgggacatattacaGagacattcacacctacagtg	10	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:91445283G>A	uc001tbl.2	-	3	1518	c.899C>T	c.(898-900)TCT>TTT	p.S300F		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	300	LRR 10.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ACATATTACAGAGACATTCAC	0.428													0	0	0	0.009535	0	31	39										A	91445283	G	A	91445283	3	1	46	1	0	0	0	0	1	0	0	0	8143	942	33	1	163	1	KERA	12	91445283	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	9908309	91445283	42406612	1143	12840										
UBE2N	7334	broad.mit.edu	37	chr12	93804976	93804976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctccctcaaagggggaatCctgagggccagcaatgacca	11	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:93804976C>T	uc001tcp.2	-	2	496	c.130G>A	c.(130-132)GAT>AAT	p.D44N		NM_003348	NP_003339	P61088	UBE2N_HUMAN	ubiquitin-conjugating enzyme E2N	44					DNA double-strand break processing|double-strand break repair via homologous recombination|histone ubiquitination|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of DNA repair|positive regulation of histone modification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity|postreplication repair|protein K63-linked ubiquitination|proteolysis|regulation of histone ubiquitination|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-MMS2 complex|UBC13-UEV1A complex|ubiquitin ligase complex	ATP binding|ubiquitin binding|ubiquitin-protein ligase activity				0						AAGGGGGAATCCTGAGGGCCA	0.478								Direct_reversal_of_damage|Rad6_pathway					0	0	0	0.01441	0	51	92										T	93804976	C	T	93804976	3	4	46	1	0	0	0	0	1	0	0	0	16863	855	30	1	340	1	UBE2N	12	93804976	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2359693	93804976	40046919	1144	12841										
CCDC38	120935	broad.mit.edu	37	chr12	96284667	96284667	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacagctgtcctcccggactCctcaaggatgccttccttgt	9	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:96284667C>G	uc001tek.1	-	9	1048	c.814G>C	c.(814-816)GAG>CAG	p.E272Q		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	272										skin(1)	1						CTCCCGGACTCCTCAAGGATG	0.443													0	0	0	0.00632	0	27	45										G	96284667	C	G	96284667	3	3	46	1	0	0	0	0	1	0	0	0	2810	864	30	1	909	1	CCDC38	12	96284667	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2479691	96284667	37567228	1145	12842										
HAL	3034	broad.mit.edu	37	chr12	96382019	96382019	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatccatgggcttctagcacCtatagaatgattaaaaatat	6	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:96382019C>T	uc001tem.1	-	11	1153	c.856_splice	c.e11-1	p.V286_splice	HAL_uc009zti.1_Splice_Site|HAL_uc010suw.1_Splice_Site_p.V78_splice|HAL_uc010sux.1_Splice_Site_p.V286_splice	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase						biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CTTCTAGCACCTATAGAATGA	0.308													0	0	0	0.01441	0	105	156										T	96382019	C	T	96382019	5	4	46	1	0	0	0	0	0	0	1	0	6947	695	24	2	1162	2	HAL	12	96382019	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	97352	96382019	37469876	1146	12843										
C12orf63	374467	broad.mit.edu	37	chr12	97051853	97051853	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaatgggaaacactagtatCtcttgccattcagttcaata	6	8	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:97051853C>T	uc001tet.1	+	4	647	c.569C>T	c.(568-570)TCT>TTT	p.S190F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	190										skin(6)|ovary(1)	7						ACACTAGTATCTCTTGCCATT	0.313													0	0	0	0.012213	0	31	115										T	97051853	C	T	97051853	3	4	46	1	0	0	0	0	1	0	0	0	1706	913	32	1	579	1	C12orf63	12	97051853	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	669834	97051853	36800042	1147	12844										
SLC25A3	5250	broad.mit.edu	37	chr12	98995210	98995211	+	Frame_Shift_Del	DEL	TA	TA	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgactgcactacagtggttTatctatgactccgtgaaggt							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:98995210_98995211delTA	uc001tfo.2	+	8	1113_1114	c.993_994delTA	c.(991-996)TTTATCfs	p.F331fs	SLC25A3_uc001tfm.2_Frame_Shift_Del_p.F330fs|SLC25A3_uc001tfn.2_Frame_Shift_Del_p.F330fs|SLC25A3_uc001tfp.2_Frame_Shift_Del_p.F330fs|SLC25A3_uc001tfq.2_Frame_Shift_Del_p.F200fs|SLC25A3_uc001tfr.2_Frame_Shift_Del_p.F331fs|SLC25A3_uc001tfs.2_Frame_Shift_Del_p.F287fs|SLC25A3_uc009ztn.2_Frame_Shift_Del_p.F293fs|SLC25A3_uc001tft.2_Frame_Shift_Del_p.F330fs	NM_005888	NP_005879	Q00325	MPCP_HUMAN	solute carrier family 25 member 3 isoform a	331_332	Solcar 3.|Helical; Name=6; (Potential).				generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		TACAGTGGTTTATCTATGACTC	0.46																		81	121	---	---								-	98995211	TA	-	98995210	7	5	46	1	0	1	0	1	0	0	0	0	14493	1751	61	0	1145	0	SLC25A3	12	98995210	Frame_Shift_Del	DEL	TA	TCGA-DK-A1AC-01A-11D-A13W-08	1943357	98995210	34856685	1148	12845										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100489579	100489579	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taataagtcatccaatattaGaactaactttgttgctatga	5	6	1	2	rs12824229		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:100489579G>C	uc001tgq.2	-	7	935	c.706C>G	c.(706-708)CTA>GTA	p.L236V	UHRF1BP1L_uc001tgr.2_Missense_Mutation_p.L236V|UHRF1BP1L_uc001tgp.2_5'Flank	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	236										ovary(2)	2						TCCAATATTAGAACTAACTTT	0.303													0	0	0	0.006122	0	18	53										C	100489579	G	C	100489579	3	2	46	1	0	0	0	0	1	0	0	0	16966	933	33	1	3772	1	UHRF1BP1L	12	100489579	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1494369	100489579	33362316	1149	12846										
SLC5A8	160728	broad.mit.edu	37	chr12	101584349	101584349	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtccctcctataataattgTccagaaggtgtgtctttgca	9	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:101584349T>C	uc001thz.3	-	6	1120	c.730A>G	c.(730-732)ACA>GCA	p.T244A		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	244	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						ATAATAATTGTCCAGAAGGTG	0.373													0	0	0	0.00632	0	30	96										C	101584349	T	C	101584349	3	2	46	1	0	0	0	0	1	0	0	0	14671	1667	58	5	1142	5	SLC5A8	12	101584349	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1094770	101584349	32267546	1150	12847										
CHPT1	56994	broad.mit.edu	37	chr12	102091702	102091702	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggcgctgagcgagccgctGagcgcggcgcagctgcggcg	20	13	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:102091702G>A	uc001tin.2	+	1	286	c.63G>A	c.(61-63)CTG>CTA	p.L21L	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Silent_p.L21L	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	21					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						GCGAGCCGCTGAGCGCGGCGC	0.791													0	0	0	0.009096	0	4	1										A	102091702	G	A	102091702	2	1	46	1	0	0	0	0	0	0	0	1	3370	1277	45	1		1	CHPT1	12	102091702	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	507353	102091702	31760193	1151	12848										
ALKBH2	121642	broad.mit.edu	37	chr12	109526080	109526080	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccagaaccttctttctcacGggaagactgtggtaccagtg	11	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:109526080G>A	uc001tnx.2	-	4	1110	c.717C>T	c.(715-717)CCC>CCT	p.P239P	ALKBH2_uc001tny.2_Silent_p.P239P|ALKBH2_uc010sxj.1_Silent_p.P239P|ALKBH2_uc009zvd.2_3'UTR|ALKBH2_uc010sxk.1_3'UTR	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	239	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	TCTTTCTCACGGGAAGACTGT	0.483								Direct_reversal_of_damage					0	0	0	0.01441	0	49	193										A	109526080	G	A	109526080	2	1	46	1	0	0	0	0	0	0	0	1	527	1103	39	2		2	ALKBH2	12	109526080	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7434378	109526080	24325815	1152	12849										
RAD9B	144715	broad.mit.edu	37	chr12	110956540	110956540	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagatgagtttgacttctttCaaattggaatggacactgag	10	6	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:110956540C>G	uc001trf.3	+	7	793	c.655C>G	c.(655-657)CAA>GAA	p.Q219E	RAD9B_uc001trg.3_Missense_Mutation_p.Q219E|RAD9B_uc010sya.1_Missense_Mutation_p.Q150E|RAD9B_uc001tre.3_Missense_Mutation_p.Q147E|RAD9B_uc001trd.3_Missense_Mutation_p.Q61E	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	RAD9 homolog B	216					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2						TGACTTCTTTCAAATTGGAAT	0.279													0	0	0	0.010771	0	42	57										G	110956540	C	G	110956540	3	3	46	1	0	0	0	0	1	0	0	0	12996	827	29	1	681	1	RAD9B	12	110956540	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1430460	110956540	22895355	1153	12850										
CCDC63	160762	broad.mit.edu	37	chr12	111290763	111290763	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgcggttccttcaagatgtCtgtggtaggtgatgccagct	14	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:111290763C>T	uc001trv.1	+	2	200	c.5C>T	c.(4-6)TCT>TTT	p.S2F	CCDC63_uc009zvt.1_Intron|CCDC63_uc010sye.1_Intron|CCDC63_uc001trw.1_Intron	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	2										skin(6)|ovary(1)|pancreas(1)	8						TTCAAGATGTCTGTGGTAGGT	0.313													0	0	0	0.004656	0	27	32										T	111290763	C	T	111290763	3	4	46	1	0	0	0	0	1	0	0	0	2834	913	32	1	7	1	CCDC63	12	111290763	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	334223	111290763	22561132	1154	12851										
DTX1	1840	broad.mit.edu	37	chr12	113531504	113531504	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagaagaagcaccttaaaaaGagtacgccctccacgccctg	8	13	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:113531504G>C	uc001tuk.1	+	4	1500	c.1164G>C	c.(1162-1164)AAG>AAC	p.K388N		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	388					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						ACCTTAAAAAGAGTACGCCCT	0.582													0	0	0	0.013537	0	11	17										C	113531504	G	C	113531504	3	2	46	1	0	0	0	0	1	0	0	0	4793	956	33	1	1178	1	DTX1	12	113531504	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2240741	113531504	20320391	1155	12852										
DTX1	1840	broad.mit.edu	37	chr12	113532921	113532921	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acgcagccgcctgggaagatGgagttccacctcatccccca	10	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:113532921G>A	uc001tuk.1	+	7	1797	c.1461G>A	c.(1459-1461)ATG>ATA	p.M487I		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	487					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						CTGGGAAGATGGAGTTCCACC	0.642													0	0	0	0.010504	0	21	33										A	113532921	G	A	113532921	3	1	46	1	0	0	0	0	1	0	0	0	4793	1348	47	2	1487	2	DTX1	12	113532921	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1417	113532921	20318974	1156	12853										
SLC24A6	80024	broad.mit.edu	37	chr12	113737681	113737681	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagaagccatagactctgctGagctggaagcactgcaatgg	12	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:113737681G>A	uc001tvc.2	-	16	1866	c.1656C>T	c.(1654-1656)CTC>CTT	p.L552L	SLC24A6_uc001tuz.2_Silent_p.L257L|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Silent_p.L290L	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	552	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						AGACTCTGCTGAGCTGGAAGC	0.577													0	0	0	0.010818	0	25	37										A	113737681	G	A	113737681	2	1	46	1	0	0	0	0	0	0	0	1	14470	1277	45	1		1	SLC24A6	12	113737681	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	204760	113737681	20114214	1157	12854										
TBX3	6926	broad.mit.edu	37	chr12	115120680	115120680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgatcccaaagttctttaGcctccaggtgcaccttgggg	10	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:115120680G>A	uc001tvt.1	-	1	1290	c.326C>T	c.(325-327)GCT>GTT	p.A109V	TBX3_uc001tvu.1_Missense_Mutation_p.A109V|TBX3_uc010syw.1_Missense_Mutation_p.A109V	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	109	T-box; first part.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		AAGTTCTTTAGCCTCCAGGTG	0.592													0	0	0	0.013726	0	31	49										A	115120680	G	A	115120680	3	1	46	1	0	0	0	0	1	0	0	0	15656	971	34	2	1937	2	TBX3	12	115120680	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1382999	115120680	18731215	1158	12855										
MED13L	23389	broad.mit.edu	37	chr12	116418744	116418744	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtactggcaaggcacaatCtaaagacacaaatacaaaaa	6	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:116418744C>G	uc001tvw.2	-	23	5231	c.5176_splice	c.e23-1	p.I1726_splice		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		AAGGCACAATCTAAAGACACA	0.378													0	0	0	0.007413	0	20	45										G	116418744	C	G	116418744	5	3	46	1	0	0	0	0	0	0	1	0	9431	927	32	1	1493	1	MED13L	12	116418744	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1298064	116418744	17433151	1159	12856										
VSIG10	54621	broad.mit.edu	37	chr12	118511775	118511775	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgaagcaagtcttcatgggCtcagagagaagggagggacc	16	7	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:118511775C>T	uc001tws.2	-	5	1282	c.948G>A	c.(946-948)GAG>GAA	p.E316E		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	316	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane					0						TCTTCATGGGCTCAGAGAGAA	0.527													0	0	0	0.00499	0	17	23										T	118511775	C	T	118511775	2	4	46	1	0	0	0	0	0	0	0	1	17220	796	28	2		2	VSIG10	12	118511775	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2093031	118511775	15340120	1160	12857										
CCDC60	160777	broad.mit.edu	37	chr12	119954484	119954484	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccggaggacagtcacaataGaaaatgggatgcaaagaaaa	11	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:119954484G>A	uc001txe.2	+	8	1405	c.940G>A	c.(940-942)GAA>AAA	p.E314K	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	314										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AGTCACAATAGAAAATGGGAT	0.433													0	0	0	0.004007	0	16	58										A	119954484	G	A	119954484	3	1	46	1	0	0	0	0	1	0	0	0	2831	943	33	1	970	1	CCDC60	12	119954484	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1442709	119954484	13897411	1161	12858										
COX6A1	1337	broad.mit.edu	37	chr12	120876184	120876184	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgtggcttctccgcagctCgcatgtggaagactctcacc	10	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:120876184C>G	uc001tyf.1	+	2	132	c.106C>G	c.(106-108)CGC>GGC	p.R36G		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	36					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCCGCAGCTCGCATGTGGAA	0.637													0	0	0	0.008291	0	8	21										G	120876184	C	G	120876184	3	3	46	1	0	0	0	0	1	0	0	0	3774	884	31	1	112	1	COX6A1	12	120876184	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	921700	120876184	12975711	1162	12859										
SFRS9	8683	broad.mit.edu	37	chr12	120903591	120903591	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaatagcatcctctgcatctCtaaaaaaaacaacaacaaca	2	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:120903591C>G	uc001tyi.2	-	2	335	c.189_splice	c.e2-1	p.R63_splice	SFRS9_uc009zwy.2_Intron	NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9						mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCTGCATCTCTAAAAAAAAC	0.453													0	0	0	0.012319	0	20	42										G	120903591	C	G	120903591	5	3	46	1	0	0	0	0	0	0	1	0	14184	927	32	1	489	1	SFRS9	12	120903591	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	27407	120903591	12948304	1163	12860										
RNF10	9921	broad.mit.edu	37	chr12	120995412	120995412	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attacgatgcagctgatgaaGagggagaaaggggtgttggt	17	3	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:120995412G>A	uc001typ.3	+	6	1377	c.894G>A	c.(892-894)AAG>AAA	p.K298K	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Silent_p.K204K	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	298					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCTGATGAAGAGGGAGAAAG	0.448													0	0	0	0.004878	0	37	190										A	120995412	G	A	120995412	2	1	46	1	0	0	0	0	0	0	0	1	13422	933	33	1		1	RNF10	12	120995412	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	91821	120995412	12856483	1164	12861										
P2RX7	5027	broad.mit.edu	37	chr12	121615003	121615003	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacatcggctcaaccctctcCtacttcggtctggtaagaga	8	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:121615003C>T	uc001tzm.2	+	10	1122	c.1026C>T	c.(1024-1026)TCC>TCT	p.S342S	P2RX7_uc001tzn.2_Silent_p.S252S|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_Silent_p.S53S|P2RX7_uc001tzq.2_Silent_p.S172S	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	342						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAACCCTCTCCTACTTCGGTC	0.468													0	0	0	0.01441	0	57	76										T	121615003	C	T	121615003	2	4	46	1	0	0	0	0	0	0	0	1	11345	668	24	2		2	P2RX7	12	121615003	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	619591	121615003	12236892	1165	12862										
CLIP1	6249	broad.mit.edu	37	chr12	122817644	122817644	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtttttcctttgcctttatCagctgctcttctctctcatc	4	13	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:122817644C>G	uc001ucg.1	-	14	2863	c.2757G>C	c.(2755-2757)CTG>CTC	p.L919L	CLIP1_uc001uch.1_Silent_p.L908L|CLIP1_uc001uci.1_Silent_p.L873L|CLIP1_uc001ucj.1_Silent_p.L494L	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	919	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTGCCTTTATCAGCTGCTCTT	0.343													0	0	0	0.00499	0	18	36										G	122817644	C	G	122817644	2	3	46	1	0	0	0	0	0	0	0	1	3532	813	29	1		1	CLIP1	12	122817644	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1202641	122817644	11034251	1166	12863										
KNTC1	9735	broad.mit.edu	37	chr12	123089504	123089504	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgggcacagaagctgtgctCatagcccacaagctgaacac	10	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:123089504C>G	uc001ucv.2	+	50	5419	c.5256C>G	c.(5254-5256)CTC>CTG	p.L1752L	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1752					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AAGCTGTGCTCATAGCCCACA	0.438													0	0	0	0.008291	0	10	13										G	123089504	C	G	123089504	2	3	46	1	0	0	0	0	0	0	0	1	8428	813	29	1		1	KNTC1	12	123089504	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	271860	123089504	10762391	1167	12864										
GPR81	27198	broad.mit.edu	37	chr12	123214722	123214722	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaatcagccacggccaaattGaaaaggtaaacagtgctggg	11	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:123214722G>A	uc001ucz.2	-	1	408	c.165C>T	c.(163-165)TTC>TTT	p.F55F	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	55	Helical; Name=2; (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.N56fs*6(1)			0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CGGCCAAATTGAAAAGGTAAA	0.527													0	0	0	0.004007	0	16	11										A	123214722	G	A	123214722	2	1	46	1	0	0	0	0	0	0	0	1	6711	1281	45	1		1	GPR81	12	123214722	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	125218	123214722	10637173	1168	12865										
SETD8	387893	broad.mit.edu	37	chr12	123868753	123868753	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagagtggagccatggctaGaggtatttgcccaagtggcc	14	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:123868753G>A	uc001uew.2	+	1	50	c.8G>A	c.(7-9)AGA>AAA	p.R3K	SETD8_uc001uex.2_5'UTR	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		GCCATGGCTAGAGGTATTTGC	0.662													0	0	0	0.000602	0	5	12										A	123868753	G	A	123868753	3	1	46	1	0	0	0	0	1	0	0	0	14137	942	33	1	10	1	SETD8	12	123868753	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	654031	123868753	9983142	1169	12866										
DDX55	57696	broad.mit.edu	37	chr12	124104609	124104609	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataactgaagaagaatttgaGaagggcttgttgacaactgg	12	4	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:124104609G>T	uc001ufi.2	+	14	1749	c.1725G>T	c.(1723-1725)GAG>GAT	p.E575D	DDX55_uc001ufk.2_Missense_Mutation_p.E428D|DDX55_uc001ufl.2_Missense_Mutation_p.E182D	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	575							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		AAGAATTTGAGAAGGGCTTGT	0.393													1	0	1.40151e-16	0.010504	1.47563e-16	21	90										T	124104609	G	T	124104609	3	4	46	1	0	0	0	0	1	0	0	0	4373	933	33	3	1779	3	DDX55	12	124104609	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	235856	124104609	9747286	1170	12867										
NCOR2	9612	broad.mit.edu	37	chr12	124979754	124979754	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggcgggtagcggggctcaGtggccctccacgtctgtgcc	18	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:124979754G>A	uc010tba.1	-	1	161	c.44C>T	c.(43-45)ACT>ATT	p.T15I	NCOR2_uc010tay.1_Missense_Mutation_p.T15I|NCOR2_uc010taz.1_Missense_Mutation_p.T15I|NCOR2_uc010tbb.1_Missense_Mutation_p.T15I|NCOR2_uc010tbc.1_Missense_Mutation_p.T15I|NCOR2_uc001ugj.1_Missense_Mutation_p.T15I|NCOR2_uc001ugk.1_Missense_Mutation_p.T15I	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	15					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGGGGCTCAGTGGCCCTCCA	0.642													0	0	0	0.00308	0	7	34										A	124979754	G	A	124979754	3	1	46	1	0	0	0	0	1	0	0	0	10236	1029	36	2	7712	2	NCOR2	12	124979754	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	875145	124979754	8872141	1171	12868										
UBC	7316	broad.mit.edu	37	chr12	125398075	125398075	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcttgccagtgagtgtcttCacgaagatttgcatcccacc	9	12	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:125398075C>T	uc001ugs.3	-	2	691	c.243G>A	c.(241-243)GTG>GTA	p.V81V	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Silent_p.V81V|UBC_uc001ugt.2_Silent_p.V81V|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Intron	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	81	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGTGTCTTCACGAAGATTT	0.542													0	0	0	0.01441	0	110	169										T	125398075	C	T	125398075	2	4	46	1	0	0	0	0	0	0	0	1	16839	813	29	1		1	UBC	12	125398075	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	418321	125398075	8453820	1172	12869										
MMP17	4326	broad.mit.edu	37	chr12	132322757	132322757	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggagtggctaagcaggttCggttacctgcccccggctga	14	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:132322757C>T	uc001ujc.1	+	2	276	c.177C>T	c.(175-177)TTC>TTT	p.F59F	MMP17_uc001ujd.1_5'UTR	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	59					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		TAAGCAGGTTCGGTTACCTGC	0.642													0	0	0	0.010504	0	18	19										T	132322757	C	T	132322757	2	4	46	1	0	0	0	0	0	0	0	1	9656	883	31	1		1	MMP17	12	132322757	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6924682	132322757	1529138	1173	12870										
ULK1	8408	broad.mit.edu	37	chr12	132380364	132380364	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acatcgtggccctgtacgacTtccaggtaaggcctctgggc	12	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:132380364T>C	uc001uje.2	+	3	509	c.241T>C	c.(241-243)TTC>CTC	p.F81L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	81	Protein kinase.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCTGTACGACTTCCAGGTAAG	0.617													0	0	0	0.004482	0	7	57										C	132380364	T	C	132380364	3	2	46	1	0	0	0	0	1	0	0	0	16972	1609	56	5	251	5	ULK1	12	132380364	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	57607	132380364	1471531	1174	12871										
POLE	5426	broad.mit.edu	37	chr12	133226443	133226443	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgtcaggagcacttggcctCggactgtcttctgaggcctc	12	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:133226443C>T	uc001uks.1	-	30	3659	c.3615G>A	c.(3613-3615)CCG>CCA	p.P1205P	POLE_uc001ukr.1_Silent_p.P9P|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.P1178P	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1205					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CACTTGGCCTCGGACTGTCTT	0.493								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.008291	0	11	34										T	133226443	C	T	133226443	2	4	46	1	0	0	0	0	0	0	0	1	12196	871	31	1		1	POLE	12	133226443	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	846079	133226443	625452	1175	12872										
PGAM5	192111	broad.mit.edu	37	chr12	133294683	133294683	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcttcatctgtcacgccaaCgtcatccgctacatcgtgtg	7	14	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:133294683C>T	uc009zyv.2	+	5	723	c.696C>T	c.(694-696)AAC>AAT	p.N232N	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Silent_p.N232N	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	232						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		GTCACGCCAACGTCATCCGCT	0.562													0	0	0	0.008291	0	10	53										T	133294683	C	T	133294683	2	4	46	1	0	0	0	0	0	0	0	1	11776	535	19	2		2	PGAM5	12	133294683	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	68240	133294683	557212	1176	12873										
MPHOSPH8	54737	broad.mit.edu	37	chr13	20208066	20208066	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggacggagaggatgtgttcGaggtggagaagatcctggac	18	5	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:20208066G>C	uc001umh.2	+	1	187	c.178G>C	c.(178-180)GAG>CAG	p.E60Q	MPHOSPH8_uc001umf.1_Missense_Mutation_p.E60Q|MPHOSPH8_uc001umg.2_Missense_Mutation_p.E60Q	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	60	Chromo.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GGATGTGTTCGAGGTGGAGAA	0.657													0	0	0	0.004672	0	3	5										C	20208066	G	C	20208066	3	2	46	1	0	0	0	0	1	0	0	0	9727	1059	37	1	180	1	MPHOSPH8	13	20208066	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		20208066	94961812	1177	12874										
ZMYM5	9205	broad.mit.edu	37	chr13	20425496	20425496	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtatcacttactgcttaccAggactatgatgagttgcaaa	8	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:20425496A>G	uc010tcn.1	-	4	850	c.585T>C	c.(583-585)CCT>CCC	p.P195P	ZMYM5_uc001umm.1_Silent_p.P19P|ZMYM5_uc001umn.2_Silent_p.P195P|ZMYM5_uc001umo.2_Silent_p.P195P	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	195						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		ACTGCTTACCAGGACTATGAT	0.383													0	0	0	0.007413	0	20	78										G	20425496	A	G	20425496	2	3	46	1	0	0	0	0	0	0	0	1	17700	202	7	5		5	ZMYM5	13	20425496	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	217430	20425496	94744382	1178	12875										
XPO4	64328	broad.mit.edu	37	chr13	21371070	21371070	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgtcaatctgggtagcctCagcaatgccacacagggcct	11	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:21371070C>T	uc001unq.3	-	17	2485	c.2449G>A	c.(2449-2451)GAG>AAG	p.E817K		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	817					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TGGGTAGCCTCAGCAATGCCA	0.428													0	0	0	0.007413	0	18	68										T	21371070	C	T	21371070	3	4	46	1	0	0	0	0	1	0	0	0	17443	835	29	1	1034	1	XPO4	13	21371070	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	945574	21371070	93798808	1179	12876										
MRP63	78988	broad.mit.edu	37	chr13	21751241	21751241	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgggagcaggagcgcggccaCgccgcggtgcgcaggaggga	21	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:21751241C>T	uc001unw.2	+	2	676	c.186C>T	c.(184-186)CAC>CAT	p.H62H	SKA3_uc001unt.2_5'Flank|SKA3_uc001unv.2_5'Flank|SKA3_uc001unu.2_5'Flank	NM_024026	NP_076931	Q9BQC6	RT63_HUMAN	mitochondrial ribosomal protein 63	62											0		all_cancers(29;2.76e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.43e-05)|Epithelial(112;0.000285)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|Lung(94;0.0932)		AGCGCGGCCACGCCGCGGTGC	0.642													0	0	0	0.001168	0	5	25										T	21751241	C	T	21751241	2	4	46	1	0	0	0	0	0	0	0	1	9773	535	19	2		2	MRP63	13	21751241	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	380171	21751241	93418637	1180	12877										
MIPEP	4285	broad.mit.edu	37	chr13	24411850	24411850	+	Frame_Shift_Del	DEL	C	C	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacaactgggagttgatagtCtccatcttcctttagtctgc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:24411850delC	uc001uox.3	-	13	1484	c.1384delG	c.(1384-1386)GACfs	p.D462fs		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	462					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		AGTTGATAGTCTCCATCTTCC	0.393																		24	117	---	---								-	24411850	C	-	24411850	7	5	46	1	0	1	0	1	0	0	0	0	9592	913	32	0	785	0	MIPEP	13	24411850	Frame_Shift_Del	DEL	C	TCGA-DK-A1AC-01A-11D-A13W-08	2660609	24411850	90758028	1181	12878										
UBL3	5412	broad.mit.edu	37	chr13	30341760	30341760	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtgcatggcttaccttgaGagtttggctctggtaatgtc	12	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:30341760G>C	uc001usp.2	-	4	1441	c.296C>G	c.(295-297)TCT>TGT	p.S99C		NM_007106	NP_009037	O95164	UBL3_HUMAN	ubiquitin-like 3 precursor	99						intracellular|plasma membrane					0		Lung SC(185;0.0281)		all cancers(112;0.0598)|GBM - Glioblastoma multiforme(144;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.147)		CTTACCTTGAGAGTTTGGCTC	0.408													0	0	0	0.004878	0	36	39										C	30341760	G	C	30341760	3	2	46	1	0	0	0	0	1	0	0	0	16883	942	33	1	65	1	UBL3	13	30341760	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5929910	30341760	84828118	1182	12879										
USPL1	10208	broad.mit.edu	37	chr13	31211905	31211905	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agattgtaaaaaacttacctCagaaatatttgcagagatag	7	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:31211905C>T	uc001utc.2	+	5	1325	c.893C>T	c.(892-894)TCA>TTA	p.S298L	USPL1_uc001utb.2_Missense_Mutation_p.S117L|USPL1_uc001utd.2_5'UTR|USPL1_uc001ute.1_5'UTR	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	298					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AAACTTACCTCAGAAATATTT	0.348													0	0	0	0.009535	0	33	85										T	31211905	C	T	31211905	3	4	46	1	0	0	0	0	1	0	0	0	17089	838	29	1	907	1	USPL1	13	31211905	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	870145	31211905	83957973	1183	12880										
N4BP2L2	10443	broad.mit.edu	37	chr13	33018001	33018001	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctttatttttccatctttTttctttatatccagtcacaa	1	9	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:33018001T>C	uc010abe.1	-	7	695	c.673A>G	c.(673-675)AAA>GAA	p.K225E	N4BP2L2_uc001uug.2_Missense_Mutation_p.K108E|N4BP2L2_uc010abd.1_Missense_Mutation_p.K138E|N4BP2L2_uc001uuh.2_Missense_Mutation_p.K56E|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.K210E	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTCCATCTTTTTTCTTTATAT	0.343													0	0	0	0.009096	0	4	8										C	33018001	T	C	33018001	3	2	46	1	0	0	0	0	1	0	0	0	10112	1850	64	5	1597	5	N4BP2L2	13	33018001	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1806096	33018001	82151877	1184	12881										
DCLK1	9201	broad.mit.edu	37	chr13	36686315	36686315	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcttggtgtactccagtttCttgaagggctctatggagcc	11	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:36686315C>G	uc001uvf.2	-	3	647	c.414G>C	c.(412-414)AAG>AAC	p.K138N		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	138	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ACTCCAGTTTCTTGAAGGGCT	0.428													0	0	0	0.005443	0	26	54										G	36686315	C	G	36686315	3	3	46	1	0	0	0	0	1	0	0	0	4291	912	32	1	1839	1	DCLK1	13	36686315	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3668314	36686315	78483563	1185	12882										
SPG20	23111	broad.mit.edu	37	chr13	36909157	36909157	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttcatttttctttcgcttaCctgaagaaacccgggaggac	8	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:36909157C>G	uc001uvn.2	-	3	1080	c.810_splice	c.e3+1	p.Q270_splice	SPG20_uc010ten.1_Intron|SPG20_uc001uvm.2_Splice_Site_p.Q270_splice|SPG20_uc001uvo.2_Splice_Site_p.Q270_splice|SPG20_uc001uvq.2_Splice_Site_p.Q270_splice|SPG20_uc001uvp.2_Splice_Site_p.Q270_splice	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin						cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CTTTCGCTTACCTGAAGAAAC	0.378													0	0	0	0.009718	0	39	65										G	36909157	C	G	36909157	5	3	46	1	0	0	0	0	0	0	1	0	15041	521	18	4	1221	4	SPG20	13	36909157	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	222842	36909157	78260721	1186	12883										
TSC22D1	8848	broad.mit.edu	37	chr13	45147906	45147906	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgatgaataatcccagtttGagcaggtggaaccacttgcg	11	9	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:45147906G>A	uc001uzn.3	-	1	2796	c.2305C>T	c.(2305-2307)CAA>TAA	p.Q769*	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	769	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		ATCCCAGTTTGAGCAGGTGGA	0.493													0	0	0	0.006122	0	19	62										A	45147906	G	A	45147906	4	1	46	1	0	0	0	0	0	1	0	0	16604	1299	45	1	1057	1	TSC22D1	13	45147906	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8238749	45147906	70021972	1187	12884										
TSC22D1	8848	broad.mit.edu	37	chr13	45149590	45149590	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcccattgatcacaacattCtgttgtggaaggtgaggcaa	10	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:45149590C>T	uc001uzn.3	-	1	1112	c.621G>A	c.(619-621)CAG>CAA	p.Q207Q	TSC22D1_uc001uzo.1_Silent_p.Q207Q	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	207	His-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TCACAACATTCTGTTGTGGAA	0.353													0	0	0	0.014323	0	22	19										T	45149590	C	T	45149590	2	4	46	1	0	0	0	0	0	0	0	1	16604	912	32	1		1	TSC22D1	13	45149590	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1684	45149590	70020288	1188	12885										
KCTD4	386618	broad.mit.edu	37	chr13	45768414	45768414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccttcgggcaatagaagttCtccatttcgtaggaagttta	9	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:45768414C>T	uc001uzx.3	-	2	693	c.289G>A	c.(289-291)GAA>AAA	p.E97K	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	97	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		AATAGAAGTTCTCCATTTCGT	0.443													0	0	0	0.01441	0	86	127										T	45768414	C	T	45768414	3	4	46	1	0	0	0	0	1	0	0	0	8111	922	32	1	494	1	KCTD4	13	45768414	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	618824	45768414	69401464	1189	12886										
LCP1	3936	broad.mit.edu	37	chr13	46701847	46701847	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccaatttttcgggccataGagatggcatatctaaaaggg	10	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:46701847G>C	uc001vaz.3	-	16	1889	c.1763C>G	c.(1762-1764)TCT>TGT	p.S588C	LCP1_uc010ack.2_Missense_Mutation_p.S157C|LCP1_uc001vay.3_Missense_Mutation_p.S185C|LCP1_uc001vba.3_Missense_Mutation_p.S588C	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	588	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCGGGCCATAGAGATGGCATA	0.493			T	BCL6	NHL 								0	0	0	0.01441	0	59	36										C	46701847	G	C	46701847	3	2	46	1	0	0	0	0	1	0	0	0	8691	942	33	1	124	1	LCP1	13	46701847	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	933433	46701847	68468031	1190	12887										
LPAR6	10161	broad.mit.edu	37	chr13	48985612	48985612	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctgcaccatgaacttcagaGaatctgaagtcacttctcct	6	12	5	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:48985612G>A	uc010acu.2	-	1	2042	c.948C>T	c.(946-948)TTC>TTT	p.F316F	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Silent_p.F316F|LPAR6_uc001vcf.2_Silent_p.F316F	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GAACTTCAGAGAATCTGAAGT	0.338													0	0	0	0.011902	0	46	61										A	48985612	G	A	48985612	2	1	46	1	0	0	0	0	0	0	0	1	8909	933	33	1		1	LPAR6	13	48985612	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2283765	48985612	66184266	1191	12888										
RCBTB2	1102	broad.mit.edu	37	chr13	49085972	49085972	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggctggttgccactgttgccGagtccaagctgcccgtttcc	12	14	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:49085972G>A	uc001vch.2	-	9	1088	c.717C>T	c.(715-717)CTC>CTT	p.L239L	RCBTB2_uc010tgg.1_Silent_p.L244L|RCBTB2_uc001vci.2_Silent_p.L215L|RCBTB2_uc010tgh.1_Missense_Mutation_p.S13L|RCBTB2_uc001vcj.2_Silent_p.L243L|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_Silent_p.L215L	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	239	RCC1 4.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CACTGTTGCCGAGTCCAAGCT	0.527													0	0	0	0.013537	0	12	31										A	49085972	G	A	49085972	2	1	46	1	0	0	0	0	0	0	0	1	13172	1045	37	1		1	RCBTB2	13	49085972	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	100360	49085972	66083906	1192	12889										
ATP7B	540	broad.mit.edu	37	chr13	52548420	52548420	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaagtgcctcgatagccctCtgcagagccactgggctggt	14	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:52548420C>T	uc001vfw.2	-	2	1093	c.936G>A	c.(934-936)CAG>CAA	p.Q312Q	ATP7B_uc010adv.2_Silent_p.Q312Q|ATP7B_uc001vfx.2_Silent_p.Q312Q|ATP7B_uc001vfy.2_Intron|ATP7B_uc010tgt.1_Silent_p.Q312Q|ATP7B_uc010tgu.1_Silent_p.Q312Q|ATP7B_uc010tgv.1_Silent_p.Q312Q|ATP7B_uc010tgw.1_Silent_p.Q280Q	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	312	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CGATAGCCCTCTGCAGAGCCA	0.502									Wilson_disease				0	0	0	0.008361	0	29	65										T	52548420	C	T	52548420	2	4	46	1	0	0	0	0	0	0	0	1	1191	912	32	1		1	ATP7B	13	52548420	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3462448	52548420	62621458	1193	12890										
OLFM4	10562	broad.mit.edu	37	chr13	53624514	53624514	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catatgctaatgttgcttggCaagatattgactttgctgtg	10	6	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:53624514C>G	uc001vhl.2	+	5	1141	c.1141C>G	c.(1141-1143)CAA>GAA	p.Q381E	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	381	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TGTTGCTTGGCAAGATATTGA	0.413													0	0	0	0.01441	0	57	149										G	53624514	C	G	53624514	3	3	46	1	0	0	0	0	1	0	0	0	10855	711	25	4	1159	4	OLFM4	13	53624514	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1076094	53624514	61545364	1194	12891										
PCDH17	27253	broad.mit.edu	37	chr13	58208221	58208221	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcctactctatcctgccctCgcacatcggcgacgtgtcta	7	16	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:58208221C>T	uc001vhq.1	+	1	2433	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L	PCDH17_uc010aec.1_Missense_Mutation_p.S514L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	514	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCCTGCCCTCGCACATCGGC	0.592													0	0	0	0.00333	0	23	19										T	58208221	C	T	58208221	3	4	46	1	0	0	0	0	1	0	0	0	11512	893	31	1	1543	1	PCDH17	13	58208221	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4583707	58208221	56961657	1195	12892										
PCDH20	64881	broad.mit.edu	37	chr13	61985735	61985735	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccatgactgtggagtggaGaggctcgggataaccatgat	14	8	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:61985735G>A	uc001vid.3	-	2	2861	c.2497C>T	c.(2497-2499)CTC>TTC	p.L833F	PCDH20_uc010thj.1_Missense_Mutation_p.L833F	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	806	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GTGGAGTGGAGAGGCTCGGGA	0.413													0	0	0	0.010818	0	33	50										A	61985735	G	A	61985735	3	1	46	1	0	0	0	0	1	0	0	0	11515	942	33	1	362	1	PCDH20	13	61985735	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3777514	61985735	53184143	1196	12893										
DACH1	1602	broad.mit.edu	37	chr13	72134058	72134058	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcccctcctccagagagggGgcaggtgaggggctatcagg	16	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:72134058G>T	uc010thn.1	-	6	1752	c.1329C>A	c.(1327-1329)GCC>GCA	p.A443A	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	495					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CCAGAGAGGGGGCAGGTGAGG	0.542													1	0	0.00116845	0.001168	0.00118816	5	13										T	72134058	G	T	72134058	2	4	46	1	0	0	0	0	0	0	0	1	4220	1219	43	4		4	DACH1	13	72134058	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10148323	72134058	43035820	1197	12894										
KCTD12	115207	broad.mit.edu	37	chr13	77459558	77459558	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacacctccttggccagcgaCgtctttccgcaaacggtgat	9	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:77459558C>T	uc010aeu.1	-	1	983	c.726G>A	c.(724-726)ACG>ACA	p.T242T	KCTD12_uc001vka.1_Silent_p.T242T	NM_138444	NP_612453	Q96CX2	KCD12_HUMAN	potassium channel tetramerisation domain	242						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(1)	1		Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.0499)		TGGCCAGCGACGTCTTTCCGC	0.647											OREG0022449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	8	2										T	77459558	C	T	77459558	2	4	46	1	0	0	0	0	0	0	0	1	8099	523	19	2		2	KCTD12	13	77459558	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5325500	77459558	37710320	1198	12895										
MYCBP2	23077	broad.mit.edu	37	chr13	77651516	77651516	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccaatgtgcctggaatccaGatcaacctggttgagtagaa	11	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:77651516G>A	uc001vkf.2	-	68	11468	c.11377C>T	c.(11377-11379)CTG>TTG	p.L3793L	MYCBP2_uc010aev.2_Silent_p.L3197L|MYCBP2_uc001vke.2_Silent_p.L413L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3793	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGGAATCCAGATCAACCTGG	0.423													0	0	0	0.010504	0	21	25										A	77651516	G	A	77651516	2	1	46	1	0	0	0	0	0	0	0	1	10018	933	33	1		1	MYCBP2	13	77651516	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	191958	77651516	37518362	1199	12896										
GPC6	10082	broad.mit.edu	37	chr13	93879803	93879803	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaaggctcggagctgcggaGaggtccgccaggcgtacggt	18	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:93879803G>A	uc001vlt.2	+	1	726	c.94G>A	c.(94-96)GAG>AAG	p.E32K	GPC6_uc010tig.1_Missense_Mutation_p.E32K	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	32						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAGCTGCGGAGAGGTCCGCCA	0.672											OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	8	15										A	93879803	G	A	93879803	3	1	46	1	0	0	0	0	1	0	0	0	6602	943	33	1	96	1	GPC6	13	93879803	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	16228287	93879803	21290075	1200	12897										
ATP11A	23250	broad.mit.edu	37	chr13	113508799	113508799	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgttcgagctgagcaagaCggtcctgcgccacagcggga	14	13	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:113508799C>T	uc001vsi.3	+	19	2286	c.2198C>T	c.(2197-2199)ACG>ATG	p.T733M	ATP11A_uc001vsj.3_Missense_Mutation_p.T733M|ATP11A_uc001vsm.1_Missense_Mutation_p.T609M|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	733	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTGAGCAAGACGGTCCTGCGC	0.657													0	0	0	0.001855	0	13	11										T	113508799	C	T	113508799	3	4	46	1	0	0	0	0	1	0	0	0	1119	536	19	2	2272	2	ATP11A	13	113508799	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	19628996	113508799	1661079	1201	12898										
LAMP1	3916	broad.mit.edu	37	chr13	113976673	113976673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccctggcggggctggtcctCatcgtcctcatcgcctacct	11	17	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:113976673C>T	uc001vtm.1	+	9	1472	c.1191C>T	c.(1189-1191)CTC>CTT	p.L397L	LAMP1_uc010tka.1_Silent_p.L344L	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	397	Helical; (Potential).					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GGCTGGTCCTCATCGTCCTCA	0.627													0	0	0	0.013726	0	30	15										T	113976673	C	T	113976673	2	4	46	1	0	0	0	0	0	0	0	1	8617	813	29	1		1	LAMP1	13	113976673	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	467874	113976673	1193205	1202	12899										
CCNB1IP1	57820	broad.mit.edu	37	chr14	20781943	20781943	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgaaattgtattcttgataGagacgttcctgatgtacctg	9	7	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:20781943G>C	uc001vwv.2	-	6	964	c.315C>G	c.(313-315)CTC>CTG	p.L105L	CCNB1IP1_uc001vww.2_Silent_p.L105L|CCNB1IP1_uc001vwx.2_Silent_p.L105L|CCNB1IP1_uc001vwy.2_Silent_p.L105L|CCNB1IP1_uc001vwz.2_Silent_p.L105L	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	105						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		ATTCTTGATAGAGACGTTCCT	0.338			T	HMGA2	leiomyoma								0	0	0	0.010729	0	11	37										C	20781943	G	C	20781943	2	2	46	1	0	0	0	0	0	0	0	1	2912	929	33	1		1	CCNB1IP1	14	20781943	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		20781943	86567597	1203	12900										
OSGEP	55644	broad.mit.edu	37	chr14	20916914	20916914	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caatgaaagacaggatccctGagaatgagacgtccatcccc	9	12	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:20916914G>A	uc001vxf.2	-	6	970	c.614C>T	c.(613-615)TCA>TTA	p.S205L		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	205					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		CAGGATCCCTGAGAATGAGAC	0.438													0	0	0	0.007413	0	16	42										A	20916914	G	A	20916914	3	1	46	1	0	0	0	0	1	0	0	0	11287	1294	45	1	417	1	OSGEP	14	20916914	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	134971	20916914	86432626	1204	12901										
FLJ10357	55701	broad.mit.edu	37	chr14	21549964	21549964	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccagcagtggaggggcccaGtgggggccccgcagcccctc	17	16	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21549964G>T	uc001vzp.2	+	14	2966	c.2937G>T	c.(2935-2937)CAG>CAT	p.Q979H	FLJ10357_uc001vzo.1_Missense_Mutation_p.Q58H|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.Q265H	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	979					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		GAGGGGCCCAGTGGGGGCCCC	0.711													1	0	0.000602214	0.000602	0.000613236	5	1										T	21549964	G	T	21549964	3	4	46	1	0	0	0	0	1	0	0	0	5926	1020	36	4	2991	4	FLJ10357	14	21549964	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	633050	21549964	85799576	1205	12902										
HNRNPC	3183	broad.mit.edu	37	chr14	21699232	21699232	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctctgcagccaggttaatatCtgaaaaacaaaagtaaaaat	6	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21699232C>T	uc001vzy.2	-	4	486	c.242_splice	c.e4-1	p.D81_splice	HNRNPC_uc001vzw.2_Splice_Site_p.D81_splice|HNRNPC_uc001wad.2_Intron|HNRNPC_uc001vzx.2_Intron|HNRNPC_uc001vzz.2_Splice_Site_p.D81_splice|HNRNPC_uc001waa.2_Splice_Site_p.D81_splice|HNRNPC_uc010ail.2_Splice_Site_p.D81_splice|HNRNPC_uc010tlq.1_Splice_Site|HNRNPC_uc001wab.2_Splice_Site_p.D81_splice|HNRNPC_uc001wac.2_Splice_Site_p.D81_splice|HNRNPC_uc010tlr.1_5'Flank|HNRNPC_uc001waf.2_Splice_Site_p.D81_splice|HNRNPC_uc001wae.2_Splice_Site_p.D81_splice	NM_031314	NP_112604	P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C							catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding				0	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		AGGTTAATATCTGAAAAACAA	0.338													0	0	0	0.007413	0	19	39										T	21699232	C	T	21699232	5	4	46	1	0	0	0	0	0	0	1	0	7262	927	32	1	703	1	HNRNPC	14	21699232	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	149268	21699232	85650308	1206	12903										
CHD8	57680	broad.mit.edu	37	chr14	21862166	21862166	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctcttagaagctccccatCatgccgaacaggctcccacc	6	19	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21862166C>T	uc001was.1	-	32	5045	c.4951G>A	c.(4951-4953)GAT>AAT	p.D1651N	CHD8_uc001war.1_Missense_Mutation_p.D1547N|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1930					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGCTCCCCATCATGCCGAACA	0.552													0	0	0	0.001855	0	14	20										T	21862166	C	T	21862166	3	4	46	1	0	0	0	0	1	0	0	0	3331	826	29	1	1985	1	CHD8	14	21862166	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	162934	21862166	85487374	1207	12904										
METTL3	56339	broad.mit.edu	37	chr14	21967731	21967731	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcacccaaataatttcatCtacccgttcatacctgtggg	5	13	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21967731C>T	uc001wbc.2	-	8	1449	c.1357G>A	c.(1357-1359)GAT>AAT	p.D453N	METTL3_uc001wbb.2_Missense_Mutation_p.D298N	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	453					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		ATAATTTCATCTACCCGTTCA	0.423													0	0	0	0.008361	0	31	76										T	21967731	C	T	21967731	3	4	46	1	0	0	0	0	1	0	0	0	9501	913	32	1	401	1	METTL3	14	21967731	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	105565	21967731	85381809	1208	12905										
MYH7	4625	broad.mit.edu	37	chr14	23887435	23887435	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcacttggcctcctcgagctCctcagtccgctgaatggcgt	10	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:23887435C>T	uc001wjx.2	-	30	4259	c.4153G>A	c.(4153-4155)GAG>AAG	p.E1385K	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1385	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCTCGAGCTCCTCAGTCCGC	0.637													0	0	0	0.006122	0	18	46										T	23887435	C	T	23887435	3	4	46	1	0	0	0	0	1	0	0	0	10039	864	30	1	1698	1	MYH7	14	23887435	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1919704	23887435	83462105	1209	12906										
AP1G2	8906	broad.mit.edu	37	chr14	24036487	24036487	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttggccccgcgaatctcttCgatgaggtcctgaagcttca	10	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24036487C>T	uc001wkl.2	-	2	374	c.37G>A	c.(37-39)GAA>AAA	p.E13K	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_5'UTR|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_RNA|AP1G2_uc001wkp.1_5'Flank|AP1G2_uc010tnp.1_Missense_Mutation_p.E13K|AP1G2_uc010aks.2_5'UTR|AP1G2_uc010akt.2_5'UTR|AP1G2_uc010tnq.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	13					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		CGAATCTCTTCGATGAGGTCC	0.637											OREG0022606	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	14										T	24036487	C	T	24036487	3	4	46	1	0	0	0	0	1	0	0	0	733	893	31	1	2404	1	AP1G2	14	24036487	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	149052	24036487	83313053	1210	12907										
LRRC16B	90668	broad.mit.edu	37	chr14	24528595	24528595	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatctgagcggcaatggcatGgaggacatcggggccaagat	16	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24528595G>A	uc001wlj.2	+	21	1900	c.1743G>A	c.(1741-1743)ATG>ATA	p.M581I	LRRC16B_uc001wlk.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	581										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GCAATGGCATGGAGGACATCG	0.642													0	0	0	0.00308	0	7	10										A	24528595	G	A	24528595	3	1	46	1	0	0	0	0	1	0	0	0	8972	1348	47	2	1825	2	LRRC16B	14	24528595	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	492108	24528595	82820945	1211	12908										
LRRC16B	90668	broad.mit.edu	37	chr14	24532014	24532014	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggccgaggccggaaccatGaccatgaggagaccacagat	15	11	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24532014G>A	uc001wlj.2	+	29	2822	c.2665G>A	c.(2665-2667)GAC>AAC	p.D889N	LRRC16B_uc001wlk.2_5'UTR	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	889										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CCGGAACCATGACCATGAGGA	0.627													0	0	0	0.004482	0	7	39										A	24532014	G	A	24532014	3	1	46	1	0	0	0	0	1	0	0	0	8972	1290	45	1	2779	1	LRRC16B	14	24532014	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3419	24532014	82817526	1212	12909										
RNF31	55072	broad.mit.edu	37	chr14	24617580	24617580	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggttgctacagtcacactGgaagtactgctgcttcggac	11	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24617580G>A	uc001wmn.1	+	3	702	c.453G>A	c.(451-453)CTG>CTA	p.L151L	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_5'UTR|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_5'UTR|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	151	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CAGTCACACTGGAAGTACTGC	0.557													0	0	0	0.004007	0	14	16										A	24617580	G	A	24617580	2	1	46	1	0	0	0	0	0	0	0	1	13487	1335	47	2		2	RNF31	14	24617580	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	85566	24617580	82731960	1213	12910										
REC8	9985	broad.mit.edu	37	chr14	24641766	24641766	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagaccagagggacaatgtTctactatcccaacgtgcttc	8	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24641766T>A	uc001wmr.2	+	2	432	c.5T>A	c.(4-6)TTC>TAC	p.F2Y	REC8_uc001wms.2_Missense_Mutation_p.F2Y	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	2					mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		GGGACAATGTTCTACTATCCC	0.592													0	0	0	0.010729	0	9	7										A	24641766	T	A	24641766	3	1	46	1	0	0	0	0	1	0	0	0	13199	1783	62	5	7	5	REC8	14	24641766	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	24186	24641766	82707774	1214	12911										
IPO4	79711	broad.mit.edu	37	chr14	24656644	24656644	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtagggagccatggtggtcaGagtgcgcagggagtagaaga	19	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24656644G>C	uc001wmv.1	-	6	681	c.550C>G	c.(550-552)CTG>GTG	p.L184V	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Missense_Mutation_p.L48V|IPO4_uc001wmy.1_Missense_Mutation_p.L48V|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.L184V	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	184					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		ATGGTGGTCAGAGTGCGCAGG	0.577													0	0	0	0.006122	0	16	64										C	24656644	G	C	24656644	3	2	46	1	0	0	0	0	1	0	0	0	7795	933	33	1	2795	1	IPO4	14	24656644	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14878	24656644	82692896	1215	12912										
IPO4	79711	broad.mit.edu	37	chr14	24656660	24656660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcagagtgcgcagggagtaGaagagcagcccaggagagcc	17	9	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24656660G>C	uc001wmv.1	-	6	665	c.534C>G	c.(532-534)TTC>TTG	p.F178L	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Missense_Mutation_p.F42L|IPO4_uc001wmy.1_Missense_Mutation_p.F42L|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.F178L	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	178					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		GCAGGGAGTAGAAGAGCAGCC	0.592													0	0	0	0.004007	0	16	64										C	24656660	G	C	24656660	3	2	46	1	0	0	0	0	1	0	0	0	7795	933	33	1	2811	1	IPO4	14	24656660	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	16	24656660	82692880	1216	12913										
IPO4	79711	broad.mit.edu	37	chr14	24656970	24656970	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctttcgaaaaatggtggctGagagctgggccaggctgagg	16	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24656970G>T	uc001wmv.1	-	5	442	c.311C>A	c.(310-312)TCA>TAA	p.S104*	IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_5'UTR|IPO4_uc001wmy.1_5'UTR|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Nonsense_Mutation_p.S104*	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	104					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		AATGGTGGCTGAGAGCTGGGC	0.572													1	0	3.27435e-08	0.00245	3.38028e-08	14	27										T	24656970	G	T	24656970	4	4	46	1	0	0	0	0	0	1	0	0	7795	1294	45	3	3038	3	IPO4	14	24656970	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	310	24656970	82692570	1217	12914										
TGM1	7051	broad.mit.edu	37	chr14	24731453	24731453	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaacggcctcctcctctgcGagagcgtccgtctggctctg	13	15	3	1	rs145197904	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24731453G>A	uc001wod.2	-	2	230	c.106C>T	c.(106-108)CGC>TGC	p.R36C	TGM1_uc010tog.1_5'UTR	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	36	Membrane anchorage region.				cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CCTCCTCTGCGAGAGCGTCCG	0.647													0	0	0	0.008291	0	9	32										A	24731453	G	A	24731453	3	1	46	1	0	0	0	0	1	0	0	0	15826	1058	37	1	2403	1	TGM1	14	24731453	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	74483	24731453	82618087	1218	12915										
C14orf21	161424	broad.mit.edu	37	chr14	24772312	24772312	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgaggagctgagccctgtCttggaagctgtattggccca	13	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24772312C>T	uc001wol.1	+	6	1239	c.1176C>T	c.(1174-1176)GTC>GTT	p.V392V	C14orf21_uc001wom.1_5'UTR	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	392							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		TGAGCCCTGTCTTGGAAGCTG	0.478													0	0	0	0.012319	0	21	51										T	24772312	C	T	24772312	2	4	46	1	0	0	0	0	0	0	0	1	1769	900	32	1		1	C14orf21	14	24772312	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	40859	24772312	82577228	1219	12916										
NYNRIN	57523	broad.mit.edu	37	chr14	24883866	24883866	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctcccagctcagccagtGtcactgagctgagtgatgac	10	13	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24883866G>A	uc001wpf.3	+	9	3229	c.2911G>A	c.(2911-2913)GTC>ATC	p.V971I		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	971					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CTCAGCCAGTGTCACTGAGCT	0.557													0	0	0	0.013537	0	9	16										A	24883866	G	A	24883866	3	1	46	1	0	0	0	0	1	0	0	0	10796	1377	48	2	2941	2	NYNRIN	14	24883866	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	111554	24883866	82465674	1220	12917										
NYNRIN	57523	broad.mit.edu	37	chr14	24884334	24884334	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcctcaagcagaagcctGactggcagtgggaccaggag	14	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24884334G>A	uc001wpf.3	+	9	3697	c.3379G>A	c.(3379-3381)GAC>AAC	p.D1127N		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1127					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GCAGAAGCCTGACTGGCAGTG	0.622													0	0	0	0.010729	0	12	14										A	24884334	G	A	24884334	3	1	46	1	0	0	0	0	1	0	0	0	10796	1290	45	1	3409	1	NYNRIN	14	24884334	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	468	24884334	82465206	1221	12918										
NOVA1	4857	broad.mit.edu	37	chr14	27064680	27064680	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtttctttttgcaactgaacAattgtctgtcctcccttccc	5	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:27064680A>G	uc001wpy.2	-	2	534	c.216T>C	c.(214-216)ATT>ATC	p.I72I	NOVA1_uc001wpz.2_Silent_p.I72I|NOVA1_uc001wqa.2_5'UTR|NOVA1_uc001wqb.2_Silent_p.I72I	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	72	KH 1.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GCAACTGAACAATTGTCTGTC	0.403													0	0	0	0.012319	0	22	103										G	27064680	A	G	27064680	2	3	46	1	0	0	0	0	0	0	0	1	10554	126	5	5		5	NOVA1	14	27064680	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	2180346	27064680	80284860	1222	12919										
HECTD1	25831	broad.mit.edu	37	chr14	31602842	31602842	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acatgtctccacccttgtttCtcatcctttggtggatcaag	7	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:31602842C>G	uc001wrc.1	-	23	4107	c.3618G>C	c.(3616-3618)GAG>GAC	p.E1206D	HECTD1_uc001wrd.1_Missense_Mutation_p.E721D	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1206					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACCCTTGTTTCTCATCCTTTG	0.363													0	0	0	0.00245	0	15	51										G	31602842	C	G	31602842	3	3	46	1	0	0	0	0	1	0	0	0	7039	912	32	1	4298	1	HECTD1	14	31602842	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4538162	31602842	75746698	1223	12920										
MIPOL1	145282	broad.mit.edu	37	chr14	37717025	37717051	+	Splice_Site	DEL	TTATTTTAGCTGCAAATCTTGGAGCAA	TTATTTTAGCTGCAAATCTTGGAGCAA	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttatttatctagagttggctTtattttagctgcaaatcttg					rs116728484	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:37717025_37717051delTTATTTTAGCTGCAAATCTTGGAGCAA	uc001wuc.2	+	4	444	c.-59_splice	c.e4-1		MIPOL1_uc010amr.2_Splice_Site|MIPOL1_uc001wub.3_Splice_Site|MIPOL1_uc001wud.2_Splice_Site|MIPOL1_uc010ams.2_Splice_Site|MIPOL1_uc001wue.2_Splice_Site|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AGAGTTGGCTTTATTTTAGCTGCAAATCTTGGAGCAAAAACCAGAGA	0.339																		7	26	---	---								-	37717051	TTATTTTAGCTGCAAATCTTGGAGCAA	-	37717025	8	5	46	1	0	1	0	1	0	0	1	0	9593	1856	64	0		0	MIPOL1	14	37717025	Splice_Site	DEL	TTATTTTAGCTGCAAATCTTGGAGCAA	TCGA-DK-A1AC-01A-11D-A13W-08	6114183	37717025	69632515	1224	12921										
FOXA1	3169	broad.mit.edu	37	chr14	38060825	38060825	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagtagtgggggtcccctttCaggtgcagctgggactcgtg	17	9	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:38060825C>T	uc001wuf.2	-	2	1476	c.1164G>A	c.(1162-1164)CTG>CTA	p.L388L	FOXA1_uc010tpz.1_Silent_p.L355L	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	388					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		GGTCCCCTTTCAGGTGCAGCT	0.637													0	0	0	0.004672	0	3	9										T	38060825	C	T	38060825	2	4	46	1	0	0	0	0	0	0	0	1	5989	813	29	1		1	FOXA1	14	38060825	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	343800	38060825	69288715	1225	12922										
LRFN5	145581	broad.mit.edu	37	chr14	42356993	42356993	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atagtacaaaccatatccatGagcctgatcctggttcttca	6	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:42356993G>C	uc001wvm.2	+	3	2363	c.1165G>C	c.(1165-1167)GAG>CAG	p.E389Q	LRFN5_uc010ana.2_Missense_Mutation_p.E389Q	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	389	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CCATATCCATGAGCCTGATCC	0.378										HNSCC(30;0.082)			0	0	0	0.008871	0	21	53										C	42356993	G	C	42356993	3	2	46	1	0	0	0	0	1	0	0	0	8941	1291	45	1	1167	1	LRFN5	14	42356993	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4296168	42356993	64992547	1226	12923										
FAM179B	23116	broad.mit.edu	37	chr14	45468596	45468596	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gactcatcaaacaaatctttCtgggaaatgtgcacaacttg	7	9	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:45468596C>G	uc001wvv.2	+	3	2443	c.2234C>G	c.(2233-2235)TCT>TGT	p.S745C	FAM179B_uc001wvw.2_Missense_Mutation_p.S745C|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Missense_Mutation_p.S745C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	745							binding			skin(2)|upper_aerodigestive_tract(1)	3						ACAAATCTTTCTGGGAAATGT	0.353													0	0	0	0.00245	0	13	102										G	45468596	C	G	45468596	3	3	46	1	0	0	0	0	1	0	0	0	5506	913	32	1	2244	1	FAM179B	14	45468596	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3111603	45468596	61880944	1227	12924										
FANCM	57697	broad.mit.edu	37	chr14	45605471	45605471	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcgggttctgcacctccgcGggcgccctgtggatttaccc	14	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:45605471G>A	uc001wwd.3	+	1	336	c.237G>A	c.(235-237)GCG>GCA	p.A79A	FANCM_uc001wwc.2_Silent_p.A79A|FANCM_uc010anf.2_Silent_p.A79A|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	79					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GCACCTCCGCGGGCGCCCTGT	0.597								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.006214	0	9	37										A	45605471	G	A	45605471	2	1	46	1	0	0	0	0	0	0	0	1	5671	1103	39	2		2	FANCM	14	45605471	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	136875	45605471	61744069	1228	12925										
KLHDC2	23588	broad.mit.edu	37	chr14	50238388	50238388	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctacaacatggagactggaaGatggtaaatgtggatattat	11	4	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:50238388G>A	uc001wwx.2	+	2	630	c.230G>A	c.(229-231)AGA>AAA	p.R77K	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Missense_Mutation_p.R77K|KLHDC2_uc010anp.2_Missense_Mutation_p.R77K	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	77	Kelch 1.					nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)					GAGACTGGAAGATGGTAAATG	0.229													0	0	0	0.006122	0	19	54										A	50238388	G	A	50238388	3	1	46	1	0	0	0	0	1	0	0	0	8356	942	33	1	236	1	KLHDC2	14	50238388	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4632917	50238388	57111152	1229	12926										
TXNDC16	57544	broad.mit.edu	37	chr14	52936858	52936858	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tattcttctgcttcttggatCgatgttatattcactggata	7	7	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:52936858C>T	uc001wzs.2	-	16	1964	c.1515G>A	c.(1513-1515)TCG>TCA	p.S505S	TXNDC16_uc010tqu.1_Silent_p.S500S|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	505					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					CTTCTTGGATCGATGTTATAT	0.289													0	0	0	0.013537	0	13	83										T	52936858	C	T	52936858	2	4	46	1	0	0	0	0	0	0	0	1	16792	871	31	1		1	TXNDC16	14	52936858	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2698470	52936858	54412682	1230	12927										
DLGAP5	9787	broad.mit.edu	37	chr14	55642735	55642735	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttgttgcttgagactcatCactaaaaacaatagcaaaaa	5	7	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:55642735C>T	uc001xbs.2	-	9	1268	c.1051G>A	c.(1051-1053)GAT>AAT	p.D351N	DLGAP5_uc001xbt.2_Missense_Mutation_p.D351N	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	351					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						TGAGACTCATCACTAAAAACA	0.313													0	0	0	0.006122	0	19	60										T	55642735	C	T	55642735	3	4	46	1	0	0	0	0	1	0	0	0	4563	840	29	1	1628	1	DLGAP5	14	55642735	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2705877	55642735	51706805	1231	12928										
SLC35F4	341880	broad.mit.edu	37	chr14	58047974	58047974	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcagcacaatccatgacagCaagaagacaaaggctttgtt	8	9	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:58047974C>A	uc001xdb.1	-	4	873	c.873G>T	c.(871-873)TTG>TTT	p.L291F	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.L132F	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TCCATGACAGCAAGAAGACAA	0.443													1	0	0.000274275	0.004482	0.000279426	8	20										A	58047974	C	A	58047974	3	1	46	1	0	0	0	0	1	0	0	0	14591	709	25	4	712	4	SLC35F4	14	58047974	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2405239	58047974	49301566	1232	12929										
MNAT1	4331	broad.mit.edu	37	chr14	61285476	61285476	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgttgctctgcttttggctCagcataaagatagatctacc	8	10	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:61285476C>T	uc001xfd.2	+	6	709	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	MNAT1_uc001xfe.2_Intron	NM_002431	NP_002422	P51948	MAT1_HUMAN	menage a trois 1 (CAK assembly factor)	200				Missing (in Ref. 3; AAB05248).	cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			ovary(1)|lung(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		GCTTTTGGCTCAGCATAAAGA	0.368								Direct_reversal_of_damage|NER					0	0	0	0.010504	0	21	66										T	61285476	C	T	61285476	4	4	46	1	0	0	0	0	0	1	0	0	9674	827	29	1	620	1	MNAT1	14	61285476	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3237502	61285476	46064064	1233	12930										
SYNE2	23224	broad.mit.edu	37	chr14	64608747	64608747	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcatcaaacttcagatgaaGactccgtgcattcaccaagt	7	11	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64608747G>A	uc001xgm.2	+	82	15477	c.15247G>A	c.(15247-15249)GAC>AAC	p.D5083N	SYNE2_uc001xgl.2_Missense_Mutation_p.D5083N|SYNE2_uc010apy.2_Missense_Mutation_p.D1468N|SYNE2_uc001xgn.2_Missense_Mutation_p.D45N|SYNE2_uc001xgo.2_RNA	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5083	Spectrin 2.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTCAGATGAAGACTCCGTGCA	0.383													0	0	0	0.010729	0	12	41										A	64608747	G	A	64608747	3	1	46	1	0	0	0	0	1	0	0	0	15443	942	33	1	15569	1	SYNE2	14	64608747	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3323271	64608747	42740793	1234	12931										
SYNE2	23224	broad.mit.edu	37	chr14	64680937	64680937	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaagatgaaaaggaggcctCtgagaatgaaacagacatgg	14	5	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64680937C>T	uc001xgm.2	+	106	19312	c.19082C>T	c.(19081-19083)TCT>TTT	p.S6361F	SYNE2_uc001xgl.2_Missense_Mutation_p.S6361F|SYNE2_uc010apy.2_Missense_Mutation_p.S2746F|SYNE2_uc001xgn.2_Missense_Mutation_p.S1323F|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.S331F|SYNE2_uc001xgq.2_Missense_Mutation_p.S726F|SYNE2_uc001xgr.2_Missense_Mutation_p.S144F|SYNE2_uc010tsi.1_5'UTR|SYNE2_uc001xgs.2_5'UTR|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6361	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAGGAGGCCTCTGAGAATGAA	0.468													0	0	0	0.013114	0	48	51										T	64680937	C	T	64680937	3	4	46	1	0	0	0	0	1	0	0	0	15443	913	32	1	19500	1	SYNE2	14	64680937	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	72190	64680937	42668603	1235	12932										
SYNE2	23224	broad.mit.edu	37	chr14	64685228	64685228	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggtatcacagagcagcagtCaggtactgcctgtaactggc	12	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64685228C>T	uc001xgm.2	+	108	19816	c.19586C>T	c.(19585-19587)TCA>TTA	p.S6529L	SYNE2_uc001xgl.2_Missense_Mutation_p.S6552L|SYNE2_uc010apy.2_Missense_Mutation_p.S2914L|SYNE2_uc001xgn.2_Missense_Mutation_p.S1491L|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.S499L|SYNE2_uc001xgq.2_Missense_Mutation_p.S894L|SYNE2_uc001xgr.2_Missense_Mutation_p.S312L|SYNE2_uc010tsi.1_Missense_Mutation_p.S186L|SYNE2_uc001xgs.2_Missense_Mutation_p.S186L|SYNE2_uc001xgt.2_Missense_Mutation_p.S60L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6529	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAGCAGCAGTCAGGTACTGCC	0.512													0	0	0	0.000602	0	5	19										T	64685228	C	T	64685228	3	4	46	1	0	0	0	0	1	0	0	0	15443	838	29	1	20085	1	SYNE2	14	64685228	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4291	64685228	42664312	1236	12933										
MTHFD1	4522	broad.mit.edu	37	chr14	64909033	64909033	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggaaaagttttttaacatCaaatgccggtattccggcct	8	8	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64909033C>G	uc001xhb.2	+	21	2436	c.2049C>G	c.(2047-2049)ATC>ATG	p.I683M	MTHFD1_uc010aqf.2_Missense_Mutation_p.I739M	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	683	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TTTTTAACATCAAATGCCGGT	0.527													0	0	0	0.010771	0	45	74										G	64909033	C	G	64909033	3	3	46	1	0	0	0	0	1	0	0	0	9927	816	29	1	2131	1	MTHFD1	14	64909033	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	223805	64909033	42440507	1237	12934										
ZBTB1	22890	broad.mit.edu	37	chr14	64989728	64989728	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcagtccgaaataagagaTatgtttgttgaaatgctgga	12	4	0	2	rs142978553	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64989728T>G	uc001xhh.3	+	4	1937	c.1506T>G	c.(1504-1506)GAT>GAG	p.D502E	ZBTB1_uc010aqg.2_Missense_Mutation_p.D502E|ZBTB1_uc001xhi.2_Missense_Mutation_p.D502E	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		AAATAAGAGATATGTTTGTTG	0.398													0	0	0	0.004289	0	38	97										G	64989728	T	G	64989728	3	3	46	1	0	0	0	0	1	0	0	0	17519	1403	49	5	1508	5	ZBTB1	14	64989728	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	80695	64989728	42359812	1238	12935										
ZBTB1	22890	broad.mit.edu	37	chr14	64990098	64990098	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcagttgcgactgcacaatGatatgcacaaaggcatggcc	11	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64990098G>C	uc001xhh.3	+	4	2307	c.1876G>C	c.(1876-1878)GAT>CAT	p.D626H	ZBTB1_uc010aqg.2_Missense_Mutation_p.D626H|ZBTB1_uc001xhi.2_Missense_Mutation_p.D626H	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	626	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		ACTGCACAATGATATGCACAA	0.388													0	0	0	0.01441	0	48	54										C	64990098	G	C	64990098	3	2	46	1	0	0	0	0	1	0	0	0	17519	1290	45	1	1878	1	ZBTB1	14	64990098	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	370	64990098	42359442	1239	12936										
HSPA2	3306	broad.mit.edu	37	chr14	65009223	65009223	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagtcctatacctacaacatCaagcagacggtggaagacga	10	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:65009223C>T	uc001xhj.2	+	2	1732	c.1656C>T	c.(1654-1656)ATC>ATT	p.I552I	HSPA2_uc001xhk.3_Silent_p.I552I	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	552					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CCTACAACATCAAGCAGACGG	0.552													0	0	0	0.00333	0	25	51										T	65009223	C	T	65009223	2	4	46	1	0	0	0	0	0	0	0	1	7411	816	29	1		1	HSPA2	14	65009223	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	19125	65009223	42340317	1240	12937										
ARG2	384	broad.mit.edu	37	chr14	68114822	68114822	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catttgaccctacactggctCcagccacaggaactcctgtt	7	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:68114822C>T	uc001xjs.2	+	7	897	c.781C>T	c.(781-783)CCA>TCA	p.P261S		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	261					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	TACACTGGCTCCAGCCACAGG	0.388													0	0	0	0.00245	0	14	37										T	68114822	C	T	68114822	3	4	46	1	0	0	0	0	1	0	0	0	858	855	30	1	807	1	ARG2	14	68114822	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3105599	68114822	39234718	1241	12938										
PCNX	22990	broad.mit.edu	37	chr14	71575342	71575342	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactagccacagctctcactCtgtgcagtcgggcctggtca	10	15	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:71575342C>T	uc001xmo.2	+	34	6769	c.6323C>T	c.(6322-6324)TCT>TTT	p.S2108F	PCNX_uc010are.1_Missense_Mutation_p.S1997F|PCNX_uc010arf.1_Missense_Mutation_p.S896F|PCNX_uc001xmp.2_Missense_Mutation_p.S192F	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2108	Ser-rich.					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AGCTCTCACTCTGTGCAGTCG	0.532													0	0	0	0.012319	0	21	30										T	71575342	C	T	71575342	3	4	46	1	0	0	0	0	1	0	0	0	11591	913	32	1	6457	1	PCNX	14	71575342	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3460520	71575342	35774198	1242	12939										
SIPA1L1	26037	broad.mit.edu	37	chr14	72196839	72196839	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcacggcgggccttgcacaGaacactgtcggacgagagca	13	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:72196839G>A	uc001xms.2	+	18	5093	c.4745G>A	c.(4744-4746)AGA>AAA	p.R1582K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1561K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1561K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1582K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R1036K|SIPA1L1_uc001xmw.2_Missense_Mutation_p.R347K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1582					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GCCTTGCACAGAACACTGTCG	0.547													0	0	0	0.010504	0	19	44										A	72196839	G	A	72196839	3	1	46	1	0	0	0	0	1	0	0	0	14329	942	33	1	4811	1	SIPA1L1	14	72196839	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	621497	72196839	35152701	1243	12940										
RBM25	58517	broad.mit.edu	37	chr14	73577788	73577788	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtctccctgtggtattattAttcctcatgaaaactcacca	5	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:73577788A>T	uc001xno.2	+	15	2150	c.1942A>T	c.(1942-1944)ATT>TTT	p.I648F	RBM25_uc010ttu.1_Missense_Mutation_p.I648F|RBM25_uc001xnp.2_Missense_Mutation_p.I443F	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	648					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TGGTATTATTATTCCTCATGA	0.468													0	0	0	0.013537	0	11	42										T	73577788	A	T	73577788	3	4	46	1	0	0	0	0	1	0	0	0	13125	449	16	5	1996	5	RBM25	14	73577788	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1380949	73577788	33771752	1244	12941										
TTLL5	23093	broad.mit.edu	37	chr14	76238194	76238194	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgccaaagaggatgaacaGatggtaaggcttttcttact	11	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:76238194G>C	uc001xrx.2	+	21	2338	c.2133G>C	c.(2131-2133)CAG>CAC	p.Q711H	TTLL5_uc010ask.1_Missense_Mutation_p.Q725H|TTLL5_uc001xrz.2_Missense_Mutation_p.Q286H|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	711					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		AGGATGAACAGATGGTAAGGC	0.328													0	0	0	0.005524	0	37	53										C	76238194	G	C	76238194	3	2	46	1	0	0	0	0	1	0	0	0	16727	933	33	1	2211	1	TTLL5	14	76238194	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2660406	76238194	31111346	1245	12942										
ZC3H14	79882	broad.mit.edu	37	chr14	89039256	89039256	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcagagtagttgggtatatGaaacaggacgtttgtgtgaa	14	3	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:89039256G>C	uc001xww.2	+	6	991	c.766G>C	c.(766-768)GAA>CAA	p.E256Q	ZC3H14_uc010twd.1_Missense_Mutation_p.E256Q|ZC3H14_uc010twe.1_Missense_Mutation_p.E256Q|ZC3H14_uc001xwx.2_Missense_Mutation_p.E256Q|ZC3H14_uc010twf.1_Missense_Mutation_p.E101Q|ZC3H14_uc001xwy.2_Missense_Mutation_p.E222Q|ZC3H14_uc010twg.1_Missense_Mutation_p.E101Q|ZC3H14_uc001xxa.2_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	256						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTGGGTATATGAAACAGGACG	0.408													0	0	0	0.004289	0	39	102										C	89039256	G	C	89039256	3	2	46	1	0	0	0	0	1	0	0	0	17563	1291	45	1	788	1	ZC3H14	14	89039256	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	12801062	89039256	18310284	1246	12943										
TTC7B	145567	broad.mit.edu	37	chr14	91196427	91196427	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagatggcttacccatttttGaaatagaggacatgggctct	10	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:91196427G>A	uc001xyp.2	-	5	812	c.690C>T	c.(688-690)TTC>TTT	p.F230F		NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	230	TPR 2.						binding			ovary(2)	2		Melanoma(154;0.222)				ACCCATTTTTGAAATAGAGGA	0.388													0	0	0	0.01441	0	51	127										A	91196427	G	A	91196427	2	1	46	1	0	0	0	0	0	0	0	1	16710	1281	45	1		1	TTC7B	14	91196427	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2157171	91196427	16153113	1247	12944										
CCDC88C	440193	broad.mit.edu	37	chr14	91791126	91791126	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccaggcgctacctaccgtCtgacaagtctgcgttcttgg	10	14	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:91791126C>T	uc010aty.2	-	12	1438	c.1339G>A	c.(1339-1341)GAC>AAC	p.D447N		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	447					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TACCTACCGTCTGACAAGTCT	0.602													0	0	0	0.004482	0	9	20										T	91791126	C	T	91791126	3	4	46	1	0	0	0	0	1	0	0	0	2865	913	32	1	4823	1	CCDC88C	14	91791126	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	594699	91791126	15558414	1248	12945										
CCDC88C	440193	broad.mit.edu	37	chr14	91791156	91791156	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcgttcttggacagctgctCcagctcccagccaaggtggg	13	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:91791156C>G	uc010aty.2	-	12	1408	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	437					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GACAGCTGCTCCAGCTCCCAG	0.587													0	0	0	0.013537	0	11	36										G	91791156	C	G	91791156	3	3	46	1	0	0	0	0	1	0	0	0	2865	864	30	1	4853	1	CCDC88C	14	91791156	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	30	91791156	15558384	1249	12946										
CATSPERB	79820	broad.mit.edu	37	chr14	92084066	92084066	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacagtcagtagtggtatttCaagcattcgaaaacctatgg	9	8	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:92084066C>T	uc001xzs.1	-	20	2415	c.2275G>A	c.(2275-2277)GAA>AAA	p.E759K	CATSPERB_uc010aub.1_Missense_Mutation_p.E281K	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	759					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AGTGGTATTTCAAGCATTCGA	0.313													0	0	0	0.009535	0	28	33										T	92084066	C	T	92084066	3	4	46	1	0	0	0	0	1	0	0	0	2691	835	29	1	1107	1	CATSPERB	14	92084066	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	292910	92084066	15265474	1250	12947										
OTUB2	78990	broad.mit.edu	37	chr14	94512231	94512231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttacctgctctataaaacatCccactacaacatcctttatg	2	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:94512231C>T	uc001yci.2	+	6	828	c.668C>T	c.(667-669)TCC>TTC	p.S223F		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	223	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		TATAAAACATCCCACTACAAC	0.498													0	0	0	0.004482	0	8	19										T	94512231	C	T	94512231	3	4	46	1	0	0	0	0	1	0	0	0	11312	855	30	1	690	1	OTUB2	14	94512231	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2428165	94512231	12837309	1251	12948										
VRK1	7443	broad.mit.edu	37	chr14	97313665	97313665	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attgggggtctggtctacatGacaaaaatggaaaaaggtaa	12	4	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:97313665G>A	uc001yft.2	+	5	464	c.358G>A	c.(358-360)GAC>AAC	p.D120N		NM_003384	NP_003375	Q99986	VRK1_HUMAN	vaccinia related kinase 1	120	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|stomach(1)	2		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		TGGTCTACATGACAAAAATGG	0.348													0	0	0	0.001855	0	13	36										A	97313665	G	A	97313665	3	1	46	1	0	0	0	0	1	0	0	0	17216	1290	45	1	372	1	VRK1	14	97313665	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2801434	97313665	10035875	1252	12949										
CYP46A1	10858	broad.mit.edu	37	chr14	100192565	100192565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccttctccctgggccaccGctcctgcatcgggcagcagt	10	19	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:100192565G>A	uc001ygo.2	+	14	1304	c.1304G>A	c.(1303-1305)CGC>CAC	p.R435H	CYP46A1_uc001ygp.2_Missense_Mutation_p.R272H	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	435					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CTGGGCCACCGCTCCTGCATC	0.642													0	0	0	0.00245	0	15	31										A	100192565	G	A	100192565	3	1	46	1	0	0	0	0	1	0	0	0	4182	1087	38	2	1358	2	CYP46A1	14	100192565	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2878900	100192565	7156975	1253	12950										
BEGAIN	57596	broad.mit.edu	37	chr14	101012852	101012852	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcacctgcgcagcttctcCgtgaccttctccagttcctc	6	19	3	1	rs150444261		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:101012852C>G	uc010txa.1	-	2	308	c.162G>C	c.(160-162)ACG>ACC	p.T54T	BEGAIN_uc001yhp.2_5'UTR|BEGAIN_uc001yhq.2_Silent_p.T54T	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	54						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				GCAGCTTCTCCGTGACCTTCT	0.373													0	0	0	0.001168	0	4	7										G	101012852	C	G	101012852	2	3	46	1	0	0	0	0	0	0	0	1	1397	639	23	4		4	BEGAIN	14	101012852	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	820287	101012852	6336688	1254	12951										
DYNC1H1	1778	broad.mit.edu	37	chr14	102510791	102510791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaagctggcatgcaaggtcGacggacataaagacattcaa	10	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:102510791G>A	uc001yks.2	+	71	13029	c.12865G>A	c.(12865-12867)GAC>AAC	p.D4289N		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4289					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ATGCAAGGTCGACGGACATAA	0.527													0	0	0	0.008291	0	11	28										A	102510791	G	A	102510791	3	1	46	1	0	0	0	0	1	0	0	0	4841	1058	37	1	13147	1	DYNC1H1	14	102510791	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1497939	102510791	4838749	1255	12952										
TECPR2	9895	broad.mit.edu	37	chr14	102898163	102898163	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctggagatgtctggatgctCagagcgtgtccacgtgcagc	14	10	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:102898163C>T	uc001ylw.1	+	8	1263	c.1115C>T	c.(1114-1116)TCA>TTA	p.S372L	TECPR2_uc010awl.2_Missense_Mutation_p.S372L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	372							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						TCTGGATGCTCAGAGCGTGTC	0.552													0	0	0	0.00632	0	29	87										T	102898163	C	T	102898163	3	4	46	1	0	0	0	0	1	0	0	0	15741	838	29	1	1141	1	TECPR2	14	102898163	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	387372	102898163	4451377	1256	12953										
TNFAIP2	7127	broad.mit.edu	37	chr14	103593907	103593907	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggccgccgtggcgcagttCgagctgtgcgagcgcgacac	16	14	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:103593907C>T	uc001ymm.1	+	2	932	c.801C>T	c.(799-801)TTC>TTT	p.F267F	TNFAIP2_uc010awo.1_Intron|TNFAIP2_uc010txz.1_5'UTR	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	267					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			TGGCGCAGTTCGAGCTGTGCG	0.701													0	0	0	0.004672	0	3	3										T	103593907	C	T	103593907	2	4	46	1	0	0	0	0	0	0	0	1	16270	883	31	1		1	TNFAIP2	14	103593907	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	695744	103593907	3755633	1257	12954										
MARK3	4140	broad.mit.edu	37	chr14	103969477	103969477	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagctgccaagactgtctctGaacggggtccggtttaagcg	13	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:103969477G>T	uc001ymz.3	+	18	2841	c.2175G>T	c.(2173-2175)CTG>CTT	p.L725L	MARK3_uc001ymx.3_Silent_p.L716L|MARK3_uc001ymw.3_Silent_p.L701L|MARK3_uc001yna.3_Silent_p.L685L|MARK3_uc001ymy.3_Silent_p.L631L|MARK3_uc010awp.2_Silent_p.L724L|MARK3_uc010tyb.1_Silent_p.L520L|MARK3_uc010awq.2_Silent_p.L298L|MARK3_uc001ynd.2_Silent_p.L133L	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	725	KA1.						ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			GACTGTCTCTGAACGGGGTCC	0.512													1	0	3.52763e-06	0.00499	3.61253e-06	15	36										T	103969477	G	T	103969477	2	4	46	1	0	0	0	0	0	0	0	1	9314	1277	45	3		3	MARK3	14	103969477	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	375570	103969477	3380063	1258	12955										
ASPG	374569	broad.mit.edu	37	chr14	104571063	104571063	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccagggctgagcctggatgtCaggaaggaggtgcgggcgct	19	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:104571063C>T	uc001yoq.1	+	9	1101	c.1041C>T	c.(1039-1041)GTC>GTT	p.V347V	ASPG_uc001yoo.1_Silent_p.V375V|ASPG_uc001yop.1_Silent_p.V347V|ASPG_uc001yor.1_Silent_p.V347V	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	347	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GCCTGGATGTCAGGAAGGAGG	0.657													0	0	0	0.013537	0	10	6										T	104571063	C	T	104571063	2	4	46	1	0	0	0	0	0	0	0	1	1052	813	29	1		1	ASPG	14	104571063	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	601586	104571063	2778477	1259	12956										
AHNAK2	113146	broad.mit.edu	37	chr14	105408667	105408667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtgccctttgaggccggctCcctcatgcacagggccctct	12	16	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:105408667C>T	uc010axc.1	-	7	13241	c.13121G>A	c.(13120-13122)GGA>GAA	p.G4374E	AHNAK2_uc001ypx.2_Missense_Mutation_p.G4274E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4374						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAGGCCGGCTCCCTCATGCAC	0.587													0	0	0	0.01441	0	87	63										T	105408667	C	T	105408667	3	4	46	1	0	0	0	0	1	0	0	0	415	855	30	1	4270	1	AHNAK2	14	105408667	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	837604	105408667	1940873	1260	12957										
JAG2	3714	broad.mit.edu	37	chr14	105618508	105618508	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctaccactacctttgtcacaGagcaggccgccccagttggt	9	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:105618508G>A	uc001yqg.2	-	6	1313	c.909C>T	c.(907-909)CTC>CTT	p.L303L	JAG2_uc001yqf.2_5'Flank|JAG2_uc001yqh.2_Silent_p.L303L	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	303	Extracellular (Potential).|EGF-like 2; atypical.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CTTTGTCACAGAGCAGGCCGC	0.637													0	0	0	0.004289	0	33	34										A	105618508	G	A	105618508	2	1	46	1	0	0	0	0	0	0	0	1	7935	929	33	1		1	JAG2	14	105618508	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	209841	105618508	1731032	1261	12958										
NIPA2	81614	broad.mit.edu	37	chr15	23012428	23012428	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttcattgagaaagtatgaaGaaagaatggcactaaaatgg	10	3	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:23012428G>A	uc001yux.2	-	7	912	c.299C>T	c.(298-300)TCT>TTT	p.S100F	NIPA2_uc001yuy.2_Missense_Mutation_p.S100F|NIPA2_uc001yuz.2_Missense_Mutation_p.S100F|NIPA2_uc001yva.2_Missense_Mutation_p.S81F|NIPA2_uc001yvb.2_Missense_Mutation_p.S100F|NIPA2_uc010ayb.2_Missense_Mutation_p.S81F	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	100	Cytoplasmic (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		AAAGTATGAAGAAAGAATGGC	0.318													0	0	0	0.01441	0	59	101										A	23012428	G	A	23012428	3	1	46	1	0	0	0	0	1	0	0	0	10423	942	33	1	791	1	NIPA2	15	23012428	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		23012428	79518964	1262	12959										
UBE3A	7337	broad.mit.edu	37	chr15	25584354	25584354	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctttaagtttttctttgcttGagtattccggaagtaaaagc	8	6	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:25584354G>A	uc001zaq.2	-	11	2558	c.2558C>T	c.(2557-2559)TCA>TTA	p.S853L	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.S830L|UBE3A_uc001zas.2_Missense_Mutation_p.S850L|UBE3A_uc001zat.2_Missense_Mutation_p.S830L	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	853	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TTCTTTGCTTGAGTATTCCGG	0.313													0	0	0	0.00278	0	22	63										A	25584354	G	A	25584354	3	1	46	1	0	0	0	0	1	0	0	0	16876	1294	45	1	73	1	UBE3A	15	25584354	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2571926	25584354	76947038	1263	12960										
GABRA5	2558	broad.mit.edu	37	chr15	27188493	27188493	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtcttctcggcgctgataGagtttgccacggtcaattac	10	11	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:27188493G>C	uc001zbd.1	+	11	1348	c.1009G>C	c.(1009-1011)GAG>CAG	p.E337Q	GABRA5_uc001zbe.1_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	337	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGCGCTGATAGAGTTTGCCAC	0.542													0	0	0	0.001168	0	6	9										C	27188493	G	C	27188493	3	2	46	1	0	0	0	0	1	0	0	0	6164	943	33	1	1039	1	GABRA5	15	27188493	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1604139	27188493	75342899	1264	12961										
RYR3	6263	broad.mit.edu	37	chr15	33941338	33941338	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgtctgggtcggatgggtGactccagactatcacttgta	13	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:33941338G>T	uc001zhi.2	+	31	4114	c.4044G>T	c.(4042-4044)GTG>GTT	p.V1348V	RYR3_uc010bar.2_Silent_p.V1348V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1348	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCGGATGGGTGACTCCAGACT	0.532													1	0	3.73988e-18	0.00632	3.95109e-18	29	118										T	33941338	G	T	33941338	2	4	46	1	0	0	0	0	0	0	0	1	13770	1277	45	3		3	RYR3	15	33941338	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6752845	33941338	68590054	1265	12962										
PGBD4	161779	broad.mit.edu	37	chr15	34395021	34395021	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcacacctggcagaaaagtcGatgtcagtgatatcactgac	10	10	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:34395021G>A	uc001zho.2	+	1	748	c.289G>A	c.(289-291)GAT>AAT	p.D97N	C15orf24_uc001zhm.2_5'Flank|C15orf24_uc001zhn.2_5'Flank	NM_152595	NP_689808	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	97											0		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		CAGAAAAGTCGATGTCAGTGA	0.433													0	0	0	0.013726	0	36	33										A	34395021	G	A	34395021	3	1	46	1	0	0	0	0	1	0	0	0	11783	1058	37	1	291	1	PGBD4	15	34395021	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	453683	34395021	68136371	1266	12963										
AQR	9716	broad.mit.edu	37	chr15	35189812	35189812	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attaggaataacatggggctCaacaattaaggtttttgctt	9	5	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:35189812C>T	uc001ziv.2	-	21	2519	c.2338G>A	c.(2338-2340)GAG>AAG	p.E780K		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	780						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ACATGGGGCTCAACAATTAAG	0.368													0	0	0	0.012319	0	22	91										T	35189812	C	T	35189812	3	4	46	1	0	0	0	0	1	0	0	0	835	835	29	1	2179	1	AQR	15	35189812	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	794791	35189812	67341580	1267	12964										
AQR	9716	broad.mit.edu	37	chr15	35230975	35230975	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcagcacagagataaacttCtggatgagttgtgaaagaaa	10	5	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:35230975C>T	uc001ziv.2	-	9	862	c.681G>A	c.(679-681)CAG>CAA	p.Q227Q		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	227						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		AGATAAACTTCTGGATGAGTT	0.338													0	0	0	0.004007	0	17	119										T	35230975	C	T	35230975	2	4	46	1	0	0	0	0	0	0	0	1	835	912	32	1		1	AQR	15	35230975	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	41163	35230975	67300417	1268	12965										
C15orf54	400360	broad.mit.edu	37	chr15	39544580	39544580	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcagggaacagacatcacatCaaatcatccaacagatgtcc	6	12	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:39544580C>G	uc001zkg.2	+	2	612	c.244C>G	c.(244-246)CAA>GAA	p.Q82E		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	82											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		GACATCACATCAAATCATCCA	0.448													0	0	0	0.005524	0	40	150										G	39544580	C	G	39544580	3	3	46	1	0	0	0	0	1	0	0	0	1802	827	29	1	246	1	C15orf54	15	39544580	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4313605	39544580	62986812	1269	12966										
BMF	90427	broad.mit.edu	37	chr15	40396422	40396422	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaactggtctgcaatgcactGaagctttcgggcaatctgta	11	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40396422G>A	uc001zkv.2	-	3	498	c.412C>T	c.(412-414)CAG>TAG	p.Q138*	BMF_uc001zkt.2_Intron|BMF_uc001zku.2_Intron|BMF_uc001zkw.2_Nonsense_Mutation_p.Q138*	NM_033503	NP_277038	Q96LC9	BMF_HUMAN	Bcl2 modifying factor isoform bmf-1	138	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			ovary(1)	1		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		GCAATGCACTGAAGCTTTCGG	0.612													0	0	0	0.01441	0	84	90										A	40396422	G	A	40396422	4	1	46	1	0	0	0	0	0	1	0	0	1454	1299	45	1	150	1	BMF	15	40396422	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	851842	40396422	62134970	1270	12967										
BUB1B	701	broad.mit.edu	37	chr15	40505608	40505608	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataaccttttgacaatagtgGagatgctacacaaagcagaa	8	7	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40505608G>A	uc001zkx.3	+	20	2823	c.2611G>A	c.(2611-2613)GAG>AAG	p.E871K		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	871	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GACAATAGTGGAGATGCTACA	0.378			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.005443	0	28	74										A	40505608	G	A	40505608	3	1	46	1	0	0	0	0	1	0	0	0	1571	1175	41	1	2689	1	BUB1B	15	40505608	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	109186	40505608	62025784	1271	12968										
CHST14	113189	broad.mit.edu	37	chr15	40763862	40763862	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgaccgttaccgcttcctCtactgctacgtccccaaggt	8	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40763862C>G	uc001zlw.2	+	1	650	c.450C>G	c.(448-450)CTC>CTG	p.L150L		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	150	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		ACCGCTTCCTCTACTGCTACG	0.662													0	0	0	0.00499	0	17	36										G	40763862	C	G	40763862	2	3	46	1	0	0	0	0	0	0	0	1	3402	900	32	1		1	CHST14	15	40763862	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	258254	40763862	61767530	1272	12969										
CHST14	113189	broad.mit.edu	37	chr15	40764104	40764104	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caacaagtttggcgagatccGagagtaccagcaacgctatg	11	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40764104G>A	uc001zlw.2	+	1	892	c.692G>A	c.(691-693)CGA>CAA	p.R231Q		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	231	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GGCGAGATCCGAGAGTACCAG	0.597													0	0	0	0.01441	0	42	95										A	40764104	G	A	40764104	3	1	46	1	0	0	0	0	1	0	0	0	3402	1058	37	1	694	1	CHST14	15	40764104	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	242	40764104	61767288	1273	12970										
TYRO3	7301	broad.mit.edu	37	chr15	41865267	41865267	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggcatggagtacctgagctCtcggaacttcatccaccgag	11	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:41865267C>T	uc001zof.1	+	16	2167	c.1943C>T	c.(1942-1944)TCT>TTT	p.S648F		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	648	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TACCTGAGCTCTCGGAACTTC	0.572													0	0	0	0.011902	0	43	37										T	41865267	C	T	41865267	3	4	46	1	0	0	0	0	1	0	0	0	16811	913	32	1	2005	1	TYRO3	15	41865267	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1101163	41865267	60666125	1274	12971										
UBR1	197131	broad.mit.edu	37	chr15	43307928	43307928	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttctttcccaggcatttctGatgtattgtcatacatgagt	7	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:43307928G>A	uc001zqq.2	-	29	3233	c.3167C>T	c.(3166-3168)TCA>TTA	p.S1056L	UBR1_uc010udk.1_Missense_Mutation_p.S1056L	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1056					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGGCATTTCTGATGTATTGTC	0.343													0	0	0	0.01441	0	57	189										A	43307928	G	A	43307928	3	1	46	1	0	0	0	0	1	0	0	0	16898	1294	45	1	2158	1	UBR1	15	43307928	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1442661	43307928	59223464	1275	12972										
TMEM62	80021	broad.mit.edu	37	chr15	43476562	43476562	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccatcaaagaaaatacttGaaaattatgcctgttcacct	4	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:43476562G>A	uc001zqr.2	+	14	1989	c.1710G>A	c.(1708-1710)TTG>TTA	p.L570L	TMEM62_uc010bda.2_Silent_p.L405L|TMEM62_uc001zqt.2_Silent_p.L139L|CCNDBP1_uc001zqu.2_5'Flank|CCNDBP1_uc001zqv.2_5'Flank|CCNDBP1_uc010bdc.2_5'Flank|CCNDBP1_uc010bdb.2_5'Flank|CCNDBP1_uc010udl.1_5'Flank|CCNDBP1_uc001zqw.2_5'Flank|CCNDBP1_uc001zqx.2_5'Flank|CCNDBP1_uc010bdd.2_5'Flank|CCNDBP1_uc001zqy.2_5'Flank	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	570						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		GAAAATACTTGAAAATTATGC	0.418													0	0	0	0.01441	0	146	156										A	43476562	G	A	43476562	2	1	46	1	0	0	0	0	0	0	0	1	16186	1281	45	1		1	TMEM62	15	43476562	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	168634	43476562	59054830	1276	12973										
EPB42	2038	broad.mit.edu	37	chr15	43489643	43489643	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttggcacacatggtgttttCaggccacactgaacggaatc	10	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:43489643C>T	uc001zra.3	-	13	2233	c.1933G>A	c.(1933-1935)GAA>AAA	p.E645K	EPB42_uc001zqz.3_Missense_Mutation_p.E312K|EPB42_uc010bde.2_Silent_p.*436*|EPB42_uc001zrb.3_Missense_Mutation_p.E675K|EPB42_uc010udm.1_Missense_Mutation_p.E567K	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	645					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		ATGGTGTTTTCAGGCCACACT	0.498													0	0	0	0.013726	0	32	41										T	43489643	C	T	43489643	3	4	46	1	0	0	0	0	1	0	0	0	5158	835	29	1	146	1	EPB42	15	43489643	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	13081	43489643	59041749	1277	12974										
DUOX2	50506	broad.mit.edu	37	chr15	45386349	45386349	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagccagggaggacaggctCagaagttctcatagtggtgc	15	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:45386349C>T	uc010bea.2	-	34	4849	c.4646G>A	c.(4645-4647)TGA>TAA	p.*1549*	DUOX2_uc001zun.2_Silent_p.*1549*	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1549					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGGACAGGCTCAGAAGTTCTC	0.557													0	0	0	0.010729	0	10	43										T	45386349	C	T	45386349	2	4	46	1	0	0	0	0	0	0	0	1	4801	837	29	1		1	DUOX2	15	45386349	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1896706	45386349	57145043	1278	12975										
DUOX1	53905	broad.mit.edu	37	chr15	45445633	45445633	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgttctccatcagccccctCagcgtcctctcttgcctctt	5	19	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:45445633C>T	uc001zus.1	+	27	3826	c.3480C>T	c.(3478-3480)CTC>CTT	p.L1160L	DUOX1_uc001zut.1_Silent_p.L1160L|DUOX1_uc010bee.1_Silent_p.L540L	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1160	Helical; (Potential).|Interaction with TXNDC11 (By similarity).|Ferric oxidoreductase.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TCAGCCCCCTCAGCGTCCTCT	0.438													0	0	0	0.009535	0	29	101										T	45445633	C	T	45445633	2	4	46	1	0	0	0	0	0	0	0	1	4800	813	29	1		1	DUOX1	15	45445633	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	59284	45445633	57085759	1279	12976										
SHF	90525	broad.mit.edu	37	chr15	45460156	45460156	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttcacatctaaagagtccGgatggccacagggtagagca	12	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:45460156G>C	uc001zuy.2	-	8	1756	c.1261C>G	c.(1261-1263)CGG>GGG	p.R421G	SHF_uc010uen.1_Missense_Mutation_p.R237G|SHF_uc010ueo.1_Missense_Mutation_p.R237G|SHF_uc010uep.1_3'UTR|SHF_uc010ueq.1_Missense_Mutation_p.R197G|SHF_uc010uer.1_3'UTR	NM_138356	NP_612365	Q7M4L6	SHF_HUMAN	Src homology 2 domain containing F	Error:Variant_position_missing_in_B3KTY1_after_alignment										ovary(1)	1		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		TAAAGAGTCCGGATGGCCACA	0.587											OREG0023104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	29										C	45460156	G	C	45460156	3	2	46	1	0	0	0	0	1	0	0	0	14277	1115	39	4	14	4	SHF	15	45460156	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14523	45460156	57071236	1280	12977										
SHC4	399694	broad.mit.edu	37	chr15	49176534	49176534	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaactgaagattacttttgcCaaggactgttgataggaact	9	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:49176534C>A	uc001zxb.1	-	4	1180	c.751G>T	c.(751-753)GGC>TGC	p.G251C		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	251	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TTACTTTTGCCAAGGACTGTT	0.318													1	0	6.72482e-11	0.003163	7.01243e-11	15	50										A	49176534	C	A	49176534	3	1	46	1	0	0	0	0	1	0	0	0	14273	594	21	4	1177	4	SHC4	15	49176534	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3716378	49176534	53354858	1281	12978										
LEO1	123169	broad.mit.edu	37	chr15	52250986	52250986	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcatccagcatttcttcatCttcaaattcatcttcataat	1	11	8	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:52250986C>G	uc002abo.2	-	6	1214	c.1198G>C	c.(1198-1200)GAT>CAT	p.D400H	LEO1_uc010bfd.2_Intron	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	400					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		ATTTCTTCATCTTCAAATTCA	0.274													0	0	0	0.014323	0	22	65										G	52250986	C	G	52250986	3	3	46	1	0	0	0	0	1	0	0	0	8726	913	32	1	830	1	LEO1	15	52250986	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3074452	52250986	50280406	1282	12979										
GNB5	10681	broad.mit.edu	37	chr15	52416747	52416747	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagagtgctaacgcggttttCatgtccaaacaggatggaga	12	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:52416747C>T	uc002abt.1	-	12	1164	c.1099G>A	c.(1099-1101)GAA>AAA	p.E367K	GNB5_uc002abr.1_Missense_Mutation_p.E325K|GNB5_uc002abs.1_Missense_Mutation_p.E255K	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	367	WD 7.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		ACGCGGTTTTCATGTCCAAAC	0.498													0	0	0	0.006122	0	18	56										T	52416747	C	T	52416747	3	4	46	1	0	0	0	0	1	0	0	0	6521	835	29	1	96	1	GNB5	15	52416747	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	165761	52416747	50114645	1283	12980										
TEX9	374618	broad.mit.edu	37	chr15	56665652	56665652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttttaggcgtttaaatgcaGaattgcaggcaaaaacagct	9	7	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:56665652G>C	uc002adp.2	+	3	138	c.133G>C	c.(133-135)GAA>CAA	p.E45Q	TEX9_uc002ado.1_Missense_Mutation_p.E45Q|TEX9_uc010ugl.1_5'UTR|TEX9_uc002adq.1_5'UTR	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	45											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		TTTAAATGCAGAATTGCAGGC	0.284													0	0	0	0.00245	0	13	24										C	56665652	G	C	56665652	3	2	46	1	0	0	0	0	1	0	0	0	15781	943	33	1	143	1	TEX9	15	56665652	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4248905	56665652	45865740	1284	12981										
TCF12	6938	broad.mit.edu	37	chr15	57565345	57565345	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgggatattaatgaagcattCaaagagcttggccgaatgtg	12	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:57565345C>T	uc002aec.2	+	18	2075	c.1791C>T	c.(1789-1791)TTC>TTT	p.F597F	TCF12_uc010ugm.1_Silent_p.F649F|TCF12_uc010ugn.1_Silent_p.F617F|TCF12_uc002aea.2_Silent_p.F621F|TCF12_uc010bfs.2_Silent_p.F18F|TCF12_uc002aeb.2_Silent_p.F621F|TCF12_uc002aed.2_Silent_p.F597F|TCF12_uc002aee.2_Silent_p.F427F|TCF12_uc010bft.2_Silent_p.F451F|TCF12_uc010ugo.1_Silent_p.F361F|TCF12_uc010ugp.1_Silent_p.F254F|TCF12_uc010ugq.1_Silent_p.F231F|TCF12_uc010ugr.1_Silent_p.F210F	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	597	Helix-loop-helix motif.				immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATGAAGCATTCAAAGAGCTTG	0.458			T	TEC	extraskeletal myxoid chondrosarcoma								0	0	0	0.004007	0	17	57										T	57565345	C	T	57565345	2	4	46	1	0	0	0	0	0	0	0	1	15684	825	29	1		1	TCF12	15	57565345	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	899693	57565345	44966047	1285	12982										
ADAM10	102	broad.mit.edu	37	chr15	58904123	58904123	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcccttgcacagtctgaatCatcccgacacttctcagact	5	15	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:58904123C>T	uc002afd.1	-	12	2023	c.1579G>A	c.(1579-1581)GAT>AAT	p.D527N	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.D226N|ADAM10_uc002afe.1_Intron|ADAM10_uc002aff.1_Missense_Mutation_p.D64N	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	527	Extracellular (Potential).|Disintegrin.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		CAGTCTGAATCATCCCGACAC	0.428													0	0	0	0.00333	0	23	57										T	58904123	C	T	58904123	3	4	46	1	0	0	0	0	1	0	0	0	234	826	29	1	687	1	ADAM10	15	58904123	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1338778	58904123	43627269	1286	12983										
GTF2A2	2958	broad.mit.edu	37	chr15	59942969	59942969	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagttggggggtgatctgttGagactgagaaaaggtaaagg	17	2	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:59942969G>A	uc002agg.2	-	3	258	c.76C>T	c.(76-78)CAA>TAA	p.Q26*		NM_004492	NP_004483	P52657	T2AG_HUMAN	general transcription factor IIA, 2, 12kDa	26					interspecies interaction between organisms|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIA complex	protein heterodimerization activity|protein homodimerization activity|TBP-class protein binding|transcription coactivator activity			central_nervous_system(2)	2						GTGATCTGTTGAGACTGAGAA	0.368													0	0	0	0.004656	0	26	33										A	59942969	G	A	59942969	4	1	46	1	0	0	0	0	0	1	0	0	6854	1299	45	1	265	1	GTF2A2	15	59942969	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1038846	59942969	42588423	1287	12984										
USP3	9960	broad.mit.edu	37	chr15	63850344	63850344	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgccacaggccttcggaatTtggggaacacatgtttcatg	12	9	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:63850344T>G	uc002amf.2	+	6	619	c.490T>G	c.(490-492)TTG>GTG	p.L164V	USP3_uc010uii.1_Intron|USP3_uc002amg.2_Missense_Mutation_p.L79V|USP3_uc002amh.2_Missense_Mutation_p.L142V|USP3_uc010uij.1_Missense_Mutation_p.L120V|USP3_uc010uik.1_Intron|USP3_uc010bgs.2_Missense_Mutation_p.L147V|USP3_uc002ami.2_Translation_Start_Site	NM_006537	NP_006528	Q9Y6I4	UBP3_HUMAN	ubiquitin thiolesterase 3	164					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)		CCTTCGGAATTTGGGGAACAC	0.428													0	0	0	0.010818	0	31	30										G	63850344	T	G	63850344	3	3	46	1	0	0	0	0	1	0	0	0	17057	1838	64	5	512	5	USP3	15	63850344	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	3907375	63850344	38681048	1288	12985										
HERC1	8925	broad.mit.edu	37	chr15	64005075	64005075	+	Missense_Mutation	SNP	C	C	G													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgtggactagccggctctCtgcagtaagactttcactcc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64005075C>G	uc002amp.2	-	24	4631	c.4483G>C	c.(4483-4485)GAG>CAG	p.E1495Q	HERC1_uc010uil.1_Missense_Mutation_p.E479Q	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1495					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						AGCCGGCTCTCTGCAGTAAGA	0.398													0	0	0	0.00308	0	8	19										G	64005075	C	G	64005075	3	3	46	1	0	0	0	0	1	0	0	0	7057	922	32	1	10322	1	HERC1	15	64005075	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	154731	64005075	38526317	1289	12986	61	2								
HERC1	8925	broad.mit.edu	37	chr15	64005081	64005081	+	Missense_Mutation	SNP	T	T	G													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gactagccggctctctgcagTaagactttcactcctgtctc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64005081T>G	uc002amp.2	-	24	4625	c.4477A>C	c.(4477-4479)ACT>CCT	p.T1493P	HERC1_uc010uil.1_Missense_Mutation_p.T477P	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1493					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CTCTCTGCAGTAAGACTTTCA	0.383													0	0	0	0.008291	0	10	13										G	64005081	T	G	64005081	3	3	46	1	0	0	0	0	1	0	0	0	7057	1638	57	5	10328	5	HERC1	15	64005081	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	6	64005081	38526311	1290	12987	61	2								
HERC1	8925	broad.mit.edu	37	chr15	64017671	64017671	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacccaggactgagctggctGaggtaatggcagaccagcag	14	10	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64017671G>A	uc002amp.2	-	18	3536	c.3388C>T	c.(3388-3390)CAG>TAG	p.Q1130*	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1130					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGAGCTGGCTGAGGTAATGGC	0.448													0	0	0	0.006122	0	14	58										A	64017671	G	A	64017671	4	1	46	1	0	0	0	0	0	1	0	0	7057	1299	45	1	11441	1	HERC1	15	64017671	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	12590	64017671	38513721	1291	12988										
DAPK2	23604	broad.mit.edu	37	chr15	64332447	64332447	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccatgtttggactcctcattGaggcctggaacatacaatcc	8	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64332447G>C	uc002amr.2	-	2	45	c.14C>G	c.(13-15)TCA>TGA	p.S5*	DAPK2_uc010uim.1_RNA|DAPK2_uc010bgu.1_5'UTR	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	death-associated kinase 2	5					apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2				LUAD - Lung adenocarcinoma(2;0.215)		ACTCCTCATTGAGGCCTGGAA	0.488													0	0	0	0.007413	0	20	95										C	64332447	G	C	64332447	4	2	46	1	0	0	0	0	0	1	0	0	4236	1294	45	1	1142	1	DAPK2	15	64332447	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	314776	64332447	38198945	1292	12989										
SNX22	79856	broad.mit.edu	37	chr15	64445458	64445458	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccagggcatcctgtacctGaaccaggaggtgcccaagga	12	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64445458G>A	uc002anc.1	+	4	338	c.279G>A	c.(277-279)CTG>CTA	p.L93L	SNX22_uc002amz.1_Silent_p.L65L|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	93	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						TCCTGTACCTGAACCAGGAGG	0.423													0	0	0	0.011902	0	43	29										A	64445458	G	A	64445458	2	1	46	1	0	0	0	0	0	0	0	1	14894	1277	45	1		1	SNX22	15	64445458	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	113011	64445458	38085934	1293	12990										
IGDCC3	9543	broad.mit.edu	37	chr15	65622908	65622908	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgagctggctgaggttgtagGaggagacggttccaggcagc	18	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:65622908G>A	uc002aos.2	-	10	1985	c.1733C>T	c.(1732-1734)TCC>TTC	p.S578F	IGDCC3_uc002aor.1_5'Flank	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	578	Extracellular (Potential).|Fibronectin type-III 2.									ovary(3)	3						GAGGTTGTAGGAGGAGACGGT	0.667													0	0	0	0.003954	0	25	36										A	65622908	G	A	65622908	3	1	46	1	0	0	0	0	1	0	0	0	7568	1174	41	1	731	1	IGDCC3	15	65622908	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1177450	65622908	36908484	1294	12991										
C15orf44	81556	broad.mit.edu	37	chr15	65890802	65890802	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgccaaatctatcagttttCtagaatatgataattaatag	5	5	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:65890802C>T	uc002apd.2	-	6	942	c.606_splice	c.e6-1	p.G202_splice	C15orf44_uc010uix.1_Splice_Site_p.G238_splice|C15orf44_uc010uiz.1_Splice_Site_p.G166_splice|C15orf44_uc010uja.1_Splice_Site_p.G153_splice|C15orf44_uc010ujb.1_Splice_Site_p.G123_splice|C15orf44_uc002ape.3_Splice_Site_p.G202_splice|C15orf44_uc010uiy.1_Splice_Site_p.G123_splice	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2											ovary(1)	1						TATCAGTTTTCTAGAATATGA	0.378													0	0	0	0.006214	0	10	35										T	65890802	C	T	65890802	5	4	46	1	0	0	0	0	0	0	1	0	1798	927	32	1	979	1	C15orf44	15	65890802	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	267894	65890802	36640590	1295	12992										
SMAD3	4088	broad.mit.edu	37	chr15	67473685	67473685	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacgcctcgcagccatccatGactgtggatggcttcaccga	10	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:67473685G>A	uc002aqj.2	+	6	1063	c.765G>A	c.(763-765)ATG>ATA	p.M255I	SMAD3_uc010ujr.1_Missense_Mutation_p.M150I|SMAD3_uc010ujs.1_Missense_Mutation_p.M211I|SMAD3_uc010ujt.1_Missense_Mutation_p.M60I	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	255	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		AGCCATCCATGACTGTGGATG	0.597													0	0	0	0.004482	0	7	22										A	67473685	G	A	67473685	3	1	46	1	0	0	0	0	1	0	0	0	14759	1290	45	1	865	1	SMAD3	15	67473685	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1582883	67473685	35057707	1296	12993										
AAGAB	79719	broad.mit.edu	37	chr15	67495178	67495178	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcagtgctcttcatcagatGaaaggccttcaatttcatct	6	10	7	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:67495178G>A	uc002aqk.3	-	10	1034	c.929C>T	c.(928-930)TCA>TTA	p.S310L	AAGAB_uc002aql.2_Missense_Mutation_p.S201L|AAGAB_uc010uju.1_Missense_Mutation_p.S201L	NM_024666	NP_078942	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin-binding protein p34	310					protein transport	cytoplasm					0						TTCATCAGATGAAAGGCCTTC	0.448													0	0	0	0.004007	0	13	46										A	67495178	G	A	67495178	3	1	46	1	0	0	0	0	1	0	0	0	15	1294	45	1	22	1	AAGAB	15	67495178	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	21493	67495178	35036214	1297	12994										
ANP32A	8125	broad.mit.edu	37	chr15	69080226	69080226	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttcgagtttgccttcattCgaccgactgttgtccaggac	9	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:69080226C>T	uc002arl.2	-	2	258	c.87G>A	c.(85-87)TCG>TCA	p.S29S		NM_006305	NP_006296	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	29	LRR 1.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding				0						TGCCTTCATTCGACCGACTGT	0.502													0	0	0	0.007835	0	37	112										T	69080226	C	T	69080226	2	4	46	1	0	0	0	0	0	0	0	1	705	871	31	1		1	ANP32A	15	69080226	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1585048	69080226	33451166	1298	12995										
NOX5	79400	broad.mit.edu	37	chr15	69327705	69327705	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctggccaggtgctgatgctCagacgctgcctcacctggct	12	15	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:69327705C>T	uc002ars.1	+	6	887	c.867C>T	c.(865-867)CTC>CTT	p.L289L	NOX5_uc002arp.1_Silent_p.L271L|NOX5_uc002arq.1_Silent_p.L243L|NOX5_uc010bid.1_Silent_p.L254L|NOX5_uc002arr.1_Silent_p.L261L|NOX5_uc010bie.1_Silent_p.L89L|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	289	Helical; (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TGCTGATGCTCAGACGCTGCC	0.612													0	0	0	0.001984	0	5	16										T	69327705	C	T	69327705	2	4	46	1	0	0	0	0	0	0	0	1	10559	813	29	1		1	NOX5	15	69327705	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	247479	69327705	33203687	1299	12996										
KIF23	9493	broad.mit.edu	37	chr15	69721528	69721528	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaactaaccggaccagagcaGaagggaacagattacgtgaa	12	8	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:69721528G>A	uc002asb.2	+	10	1165	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	KIF23_uc002asc.2_Missense_Mutation_p.E350K|KIF23_uc010bii.2_Missense_Mutation_p.E240K|KIF23_uc010ukc.1_Missense_Mutation_p.E167K|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	350	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						GACCAGAGCAGAAGGGAACAG	0.368													0	0	0	0.008291	0	11	4										A	69721528	G	A	69721528	3	1	46	1	0	0	0	0	1	0	0	0	8291	943	33	1	1086	1	KIF23	15	69721528	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	393823	69721528	32809864	1300	12997										
MYO9A	4649	broad.mit.edu	37	chr15	72338155	72338155	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtaaggtggtgaataagaaaGtttgtgctttgagtcttccc	12	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72338155G>C	uc002atl.3	-	2	1223	c.750C>G	c.(748-750)AAC>AAG	p.N250K	MYO9A_uc010biq.2_Intron|MYO9A_uc002ato.2_Missense_Mutation_p.N250K|MYO9A_uc002atn.1_Missense_Mutation_p.N250K	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	250	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GAATAAGAAAGTTTGTGCTTT	0.433													0	0	0	0.012319	0	21	71										C	72338155	G	C	72338155	3	2	46	1	0	0	0	0	1	0	0	0	10084	1020	36	4	7060	4	MYO9A	15	72338155	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2616627	72338155	30193237	1301	12998										
PKM2	5315	broad.mit.edu	37	chr15	72492911	72492911	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggaagatgccacggtacaGgtgggcctgacgagctgtct	16	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72492911G>T	uc002atx.1	-	10	1634	c.1393C>A	c.(1393-1395)CTG>ATG	p.L465M	GRAMD2_uc002atq.2_5'Flank|GRAMD2_uc010bis.2_5'Flank|PKM2_uc002atr.1_Translation_Start_Site|PKM2_uc002ats.1_Missense_Mutation_p.L132M|PKM2_uc002att.1_Missense_Mutation_p.L231M|PKM2_uc002atu.1_Missense_Mutation_p.L231M|PKM2_uc010bit.1_Missense_Mutation_p.L470M|PKM2_uc010uki.1_Missense_Mutation_p.L539M|PKM2_uc002atv.1_Missense_Mutation_p.L500M|PKM2_uc002atw.1_Missense_Mutation_p.L465M|PKM2_uc002aty.1_Missense_Mutation_p.L465M|PKM2_uc010ukj.1_Missense_Mutation_p.L450M|PKM2_uc010ukk.1_Missense_Mutation_p.L391M|PKM2_uc010biu.1_Missense_Mutation_p.L486M	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	465	Interaction with POU5F1.				glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CCACGGTACAGGTGGGCCTGA	0.617													1	0	1.5842e-08	0.001855	1.63935e-08	14	51										T	72492911	G	T	72492911	3	4	46	1	0	0	0	0	1	0	0	0	11977	991	35	4	210	4	PKM2	15	72492911	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	154756	72492911	30038481	1302	12999										
PKM2	5315	broad.mit.edu	37	chr15	72499149	72499149	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catgatgcagtcggctccatCcaggactgcattggccacat	10	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72499149C>T	uc002atx.1	-	8	1301	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N	PKM2_uc002ats.1_Missense_Mutation_p.D21N|PKM2_uc002att.1_Missense_Mutation_p.D120N|PKM2_uc002atu.1_Missense_Mutation_p.D120N|PKM2_uc010bit.1_Missense_Mutation_p.D359N|PKM2_uc010uki.1_Missense_Mutation_p.D428N|PKM2_uc002atv.1_Missense_Mutation_p.D389N|PKM2_uc002atw.1_Missense_Mutation_p.D354N|PKM2_uc002aty.1_Missense_Mutation_p.D354N|PKM2_uc010ukj.1_Missense_Mutation_p.D339N|PKM2_uc010ukk.1_Missense_Mutation_p.D280N|PKM2_uc010biu.1_Missense_Mutation_p.D375N|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	354	Interaction with POU5F1.				glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	TCGGCTCCATCCAGGACTGCA	0.592													0	0	0	0.007291	0	27	21										T	72499149	C	T	72499149	3	4	46	1	0	0	0	0	1	0	0	0	11977	855	30	1	722	1	PKM2	15	72499149	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6238	72499149	30032243	1303	13000										
HEXA	3073	broad.mit.edu	37	chr15	72668266	72668266	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggccgtcgcccgtcctgcGaacgctgccgccagcagcag	14	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72668266G>A	uc002aun.3	-	1	255	c.48C>T	c.(46-48)TTC>TTT	p.F16F	CELF6_uc002auk.3_RNA|HEXA_uc010ukn.1_Silent_p.F16F|HEXA_uc002auo.3_5'UTR|HEXA_uc010bix.2_Silent_p.F16F|HEXA_uc010biy.2_5'UTR|HEXA_uc010uko.1_5'UTR|HEXA_uc010biz.1_RNA|C15orf34_uc010ukp.1_5'Flank	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	16					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						CCCGTCCTGCGAACGCTGCCG	0.627													0	0	0	0.009535	0	28	18										A	72668266	G	A	72668266	2	1	46	1	0	0	0	0	0	0	0	1	7073	1049	37	1		1	HEXA	15	72668266	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	169117	72668266	29863126	1304	13001										
ISLR	3671	broad.mit.edu	37	chr15	74468086	74468086	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgtgccctgcctggcacccCtgtggccagctcccagccgc	12	20	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:74468086C>T	uc002axg.1	+	2	1169	c.887C>T	c.(886-888)CCT>CTT	p.P296L	ISLR_uc002axh.1_Missense_Mutation_p.P296L	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	296	Ig-like.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CCTGGCACCCCTGTGGCCAGC	0.647													0	0	0	0.004656	0	22	74										T	74468086	C	T	74468086	3	4	46	1	0	0	0	0	1	0	0	0	7858	681	24	2	889	2	ISLR	15	74468086	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1799820	74468086	28063306	1305	13002										
EDC3	80153	broad.mit.edu	37	chr15	74927761	74927761	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgctcacctttgaggctaGacacttgttggccttgggtc	12	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:74927761G>A	uc002ayn.2	-	9	1669	c.1181C>T	c.(1180-1182)TCT>TTT	p.S394F	EDC3_uc002ayo.2_Missense_Mutation_p.S394F|EDC3_uc002aym.2_Missense_Mutation_p.S394F	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	394	YjeF N-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						TTTGAGGCTAGACACTTGTTG	0.532											OREG0023287	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	34	29										A	74927761	G	A	74927761	3	1	46	1	0	0	0	0	1	0	0	0	4907	942	33	1	353	1	EDC3	15	74927761	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	459675	74927761	27603631	1306	13003										
C15orf17	57184	broad.mit.edu	37	chr15	75198699	75198699	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acggccttggccaggtcccgGtgcttctctggaagttaaag	13	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75198699G>A	uc002azh.3	-	2	543	c.222C>T	c.(220-222)CAC>CAT	p.H74H	C15orf17_uc010bkh.2_5'UTR|C15orf17_uc002azg.2_Silent_p.H74H|C15orf17_uc002azf.2_Silent_p.H74H	NM_020447	NP_065180	Q5XKK7	CO017_HUMAN	hypothetical protein LOC57184	74							cytochrome-c oxidase activity				0						CCAGGTCCCGGTGCTTCTCTG	0.642													0	0	0	0.009096	0	4	14										A	75198699	G	A	75198699	2	1	46	1	0	0	0	0	0	0	0	1	1783	1252	44	2		2	C15orf17	15	75198699	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	270938	75198699	27332693	1307	13004										
PPCDC	60490	broad.mit.edu	37	chr15	75335823	75335823	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgagagagccaaacatttCtacagcccccaggacattcc	7	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75335823C>T	uc002azo.2	+	3	290	c.177C>T	c.(175-177)TTC>TTT	p.F59F		NM_021823	NP_068595	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase	59		FMN.			coenzyme A biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenoylcysteine decarboxylase activity				0						CCAAACATTTCTACAGCCCCC	0.562											OREG0023296	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	12										T	75335823	C	T	75335823	2	4	46	1	0	0	0	0	0	0	0	1	12304	912	32	1		1	PPCDC	15	75335823	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	137124	75335823	27195569	1308	13005										
C15orf39	56905	broad.mit.edu	37	chr15	75499996	75499996	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgccacagctgagcctgactCagccccagccaccagtgaag	10	16	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75499996C>G	uc002azp.3	+	2	1927	c.1607C>G	c.(1606-1608)TCA>TGA	p.S536*	C15orf39_uc002azq.3_Nonsense_Mutation_p.S536*|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	536											0						GAGCCTGACTCAGCCCCAGCC	0.617													0	0	0	0.004482	0	6	10										G	75499996	C	G	75499996	4	3	46	1	0	0	0	0	0	1	0	0	1793	838	29	1	1609	1	C15orf39	15	75499996	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	164173	75499996	27031396	1309	13006										
SIN3A	25942	broad.mit.edu	37	chr15	75668090	75668090	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcttgtaggaattcagcttGaatctacactccagcttatc	6	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75668090G>T	uc002bai.2	-	20	3766	c.3507C>A	c.(3505-3507)TTC>TTA	p.F1169L	SIN3A_uc002baj.2_Missense_Mutation_p.F1169L|SIN3A_uc010uml.1_Missense_Mutation_p.F1169L	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1169					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						AATTCAGCTTGAATCTACACT	0.483													1	0	2.05212e-20	0.005524	2.17013e-20	39	102										T	75668090	G	T	75668090	3	4	46	1	0	0	0	0	1	0	0	0	14325	1281	45	3	322	3	SIN3A	15	75668090	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	168094	75668090	26863302	1310	13007										
SH2D7	646892	broad.mit.edu	37	chr15	78393321	78393321	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaggccccagtgacatcatCtatgcagacctgaggaggat	13	10	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:78393321C>T	uc010blb.1	+	5	726	c.726C>T	c.(724-726)ATC>ATT	p.I242I		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	242											0						GTGACATCATCTATGCAGACC	0.612													0	0	0	0.007413	0	18	33										T	78393321	C	T	78393321	2	4	46	1	0	0	0	0	0	0	0	1	14239	903	32	1		1	SH2D7	15	78393321	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2725231	78393321	24138071	1311	13008										
ARNT2	9915	broad.mit.edu	37	chr15	80883951	80883951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagttccaagggcggccctCggaagtctggtcgcagtggc	16	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:80883951C>T	uc002bfr.2	+	18	2127	c.1961C>T	c.(1960-1962)TCG>TTG	p.S654L	ARNT2_uc010unm.1_Missense_Mutation_p.S643L|ARNT2_uc002bfs.2_Missense_Mutation_p.S643L	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	654					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGGCGGCCCTCGGAAGTCTGG	0.562													0	0	0	0.007413	0	19	44										T	80883951	C	T	80883951	3	4	46	1	0	0	0	0	1	0	0	0	966	893	31	1	2031	1	ARNT2	15	80883951	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2490630	80883951	21647441	1312	13009										
MEX3B	84206	broad.mit.edu	37	chr15	82336488	82336488	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acatcggtgccgttggcgtgGaagtcgttctcgtctgtgag	15	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:82336488G>A	uc002bgq.1	-	2	1038	c.723C>T	c.(721-723)TTC>TTT	p.F241F		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	241					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						CGTTGGCGTGGAAGTCGTTCT	0.642													0	0	0	0.013726	0	31	83										A	82336488	G	A	82336488	2	1	46	1	0	0	0	0	0	0	0	1	9510	1165	41	1		1	MEX3B	15	82336488	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1452537	82336488	20194904	1313	13010										
WDR73	84942	broad.mit.edu	37	chr15	85186742	85186742	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacccagtcccacacatgcaGagaggcatcatttgttgctg	9	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:85186742G>A	uc002bkw.2	-	8	1112	c.1096C>T	c.(1096-1098)CTG>TTG	p.L366L	WDR73_uc002bkv.2_RNA|WDR73_uc002bkx.2_RNA|uc002bky.1_5'Flank	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	366	WD 3.										0						CACACATGCAGAGAGGCATCA	0.468													0	0	0	0.004482	0	9	13										A	85186742	G	A	85186742	2	1	46	1	0	0	0	0	0	0	0	1	17320	933	33	1		1	WDR73	15	85186742	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2850254	85186742	17344650	1314	13011										
WDR73	84942	broad.mit.edu	37	chr15	85188819	85188819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacaggatggcagagatcccGggggtcaagaagacaaagac	14	9	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:85188819G>A	uc002bkw.2	-	7	782	c.766C>T	c.(766-768)CGG>TGG	p.R256W	WDR73_uc002bkv.2_RNA|WDR73_uc002bkx.2_RNA|WDR73_uc010upa.1_3'UTR|uc002bky.1_Missense_Mutation_p.R104Q	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	256											0						CAGAGATCCCGGGGGTCAAGA	0.617													0	0	0	0.001984	0	7	9										A	85188819	G	A	85188819	3	1	46	1	0	0	0	0	1	0	0	0	17320	1115	39	2	378	2	WDR73	15	85188819	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2077	85188819	17342573	1315	13012										
AKAP13	11214	broad.mit.edu	37	chr15	86076934	86076934	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgaagcgtatgatgcagctCaattcctagcaaccagtgct	9	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:86076934C>G	uc002blv.1	+	4	471	c.301C>G	c.(301-303)CAA>GAA	p.Q101E	AKAP13_uc002bls.2_Missense_Mutation_p.Q101E|AKAP13_uc002blt.1_Missense_Mutation_p.Q101E|AKAP13_uc002blu.1_Missense_Mutation_p.Q101E	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	101					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TGATGCAGCTCAATTCCTAGC	0.493													0	0	0	0.010504	0	20	57										G	86076934	C	G	86076934	3	3	46	1	0	0	0	0	1	0	0	0	449	827	29	1	311	1	AKAP13	15	86076934	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	888115	86076934	16454458	1316	13013										
AKAP13	11214	broad.mit.edu	37	chr15	86087153	86087153	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtgagcttggccttggagcGaggctatcacaagctgcacc	13	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:86087153G>A	uc002blv.1	+	5	799	c.629G>A	c.(628-630)CGA>CAA	p.R210Q	AKAP13_uc002blt.1_Missense_Mutation_p.R210Q|AKAP13_uc002blu.1_Missense_Mutation_p.R210Q	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	210					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCCTTGGAGCGAGGCTATCAC	0.582													0	0	0	0.004482	0	9	45										A	86087153	G	A	86087153	3	1	46	1	0	0	0	0	1	0	0	0	449	1058	37	1	643	1	AKAP13	15	86087153	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10219	86087153	16444239	1317	13014										
ISG20	3669	broad.mit.edu	37	chr15	89182687	89182687	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcctggctcgttgcagcctCgtgaacgtccacggtgctgt	14	13	0	1	rs144037981		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:89182687C>T	uc002bmv.1	+	2	383	c.90C>T	c.(88-90)CTC>CTT	p.L30L	ISG20_uc002bmu.1_Intron|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	30					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			GTTGCAGCCTCGTGAACGTCC	0.647											OREG0023441	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	18										T	89182687	C	T	89182687	2	4	46	1	0	0	0	0	0	0	0	1	7854	871	31	1		1	ISG20	15	89182687	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3095534	89182687	13348705	1318	13015										
ACAN	176	broad.mit.edu	37	chr15	89401276	89401276	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacctggtttctggtaccacGagtggcagcggtgaatcttc	13	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:89401276G>A	uc010upo.1	+	12	5834	c.5460G>A	c.(5458-5460)ACG>ACA	p.T1820T	ACAN_uc010upp.1_Silent_p.T1820T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1820					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGTACCACGAGTGGCAGCG	0.522													0	0	0	0.001168	0	5	26										A	89401276	G	A	89401276	2	1	46	1	0	0	0	0	0	0	0	1	117	1045	37	1		1	ACAN	15	89401276	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	218589	89401276	13130116	1319	13016										
ACAN	176	broad.mit.edu	37	chr15	89402471	89402471	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatcagcaccagcatcccaGagtctgagtggacccagcag	10	14	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:89402471G>A	uc010upo.1	+	12	7029	c.6655G>A	c.(6655-6657)GAG>AAG	p.E2219K	ACAN_uc010upp.1_Missense_Mutation_p.E2219K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2219					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CAGCATCCCAGAGTCTGAGTG	0.572													0	0	0	0.00499	0	16	27										A	89402471	G	A	89402471	3	1	46	1	0	0	0	0	1	0	0	0	117	943	33	1	6697	1	ACAN	15	89402471	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1195	89402471	13128921	1320	13017										
CRTC3	64784	broad.mit.edu	37	chr15	91172546	91172546	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcttccttaaataaccacCcacagacatctgttcccaac	2	17	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:91172546C>T	uc002bpp.2	+	11	1154	c.1048C>T	c.(1048-1050)CCA>TCA	p.P350S	CRTC3_uc002bpo.2_Missense_Mutation_p.P350S	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	350					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			AAATAACCACCCACAGACATC	0.512			T	MAML2	salivary gland mucoepidermoid								0	0	0	0.00874	0	42	148										T	91172546	C	T	91172546	3	4	46	1	0	0	0	0	1	0	0	0	3901	623	22	2	1090	2	CRTC3	15	91172546	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1770075	91172546	11358846	1321	13018										
UNC45A	55898	broad.mit.edu	37	chr15	91488214	91488214	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccgcatgagcgcctctattCtcctcagcaagctctttgat	8	14	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:91488214C>G	uc002bqg.2	+	9	1460	c.1120C>G	c.(1120-1122)CTC>GTC	p.L374V	UNC45A_uc002bqd.2_Missense_Mutation_p.L359V	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	374					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CGCCTCTATTCTCCTCAGCAA	0.498													0	0	0	0.010729	0	12	66										G	91488214	C	G	91488214	3	3	46	1	0	0	0	0	1	0	0	0	16985	913	32	1	1154	1	UNC45A	15	91488214	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	315668	91488214	11043178	1322	13019										
PRC1	9055	broad.mit.edu	37	chr15	91517833	91517833	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actctttcctgcttggctctCtctttctccaatcgatgcat	5	14	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:91517833C>G	uc002bqm.2	-	10	1489	c.1332G>C	c.(1330-1332)GAG>GAC	p.E444D	PRC1_uc002bqn.2_Missense_Mutation_p.E444D|PRC1_uc002bqo.2_Missense_Mutation_p.E444D|PRC1_uc010uqs.1_Missense_Mutation_p.E403D	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	444	Potential.|Spectrin-fold.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCTTGGCTCTCTCTTTCTCCA	0.463													0	0	0	0.01441	0	140	127										G	91517833	C	G	91517833	3	3	46	1	0	0	0	0	1	0	0	0	12446	912	32	1	554	1	PRC1	15	91517833	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	29619	91517833	11013559	1323	13020										
LINS1	55180	broad.mit.edu	37	chr15	101115276	101115276	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtatattgctttattactctCagagtattcagaaagatttt	6	5	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:101115276C>T	uc002bwe.2	-	5	838	c.547G>A	c.(547-549)GAG>AAG	p.E183K	LINS1_uc002bwd.2_5'Flank|LINS1_uc002bwf.2_Missense_Mutation_p.E183K|LINS1_uc002bwg.2_Missense_Mutation_p.E183K|LINS1_uc002bwh.2_Missense_Mutation_p.E183K|LINS1_uc010usa.1_Missense_Mutation_p.E64K|LINS1_uc002bwi.2_Missense_Mutation_p.E183K	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	183											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TTATTACTCTCAGAGTATTCA	0.313													0	0	0	0.008361	0	31	88										T	101115276	C	T	101115276	3	4	46	1	0	0	0	0	1	0	0	0	8818	835	29	1	1742	1	LINS1	15	101115276	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9597443	101115276	1416116	1324	13021										
CHSY1	22856	broad.mit.edu	37	chr15	101718244	101718244	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaatgcggtaatctctcatCagttcaacttgtttggcctt	7	9	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:101718244C>T	uc002bwt.1	-	4	2241	c.1758G>A	c.(1756-1758)CTG>CTA	p.L586L	CHSY1_uc010usd.1_Silent_p.L314L	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	586	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATCTCTCATCAGTTCAACTT	0.478													0	0	0	0.003163	0	16	45										T	101718244	C	T	101718244	2	4	46	1	0	0	0	0	0	0	0	1	3412	813	29	1		1	CHSY1	15	101718244	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	602968	101718244	813148	1325	13022										
PRR25	388199	broad.mit.edu	37	chr16	863601	863601	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgggggacgctggccggcatCtggagacgtctgtgatctcc	16	12	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:863601C>G	uc010uut.1	+	3	949	c.949C>G	c.(949-951)CTG>GTG	p.L317V		NM_001013638	NP_001013660	Q96S07	PRR25_HUMAN	proline rich 25	317										large_intestine(1)	1						TGGCCGGCATCTGGAGACGTC	0.721													0	0	0	0.004672	0	3	4										G	863601	C	G	863601	3	3	46	1	0	0	0	0	1	0	0	0	12597	912	32	1	959	1	PRR25	16	863601	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		863601	89491152	1326	13023										
TRAF7	84231	broad.mit.edu	37	chr16	2215900	2215900	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagaatggaaacgaccttCggacccgccttttcagccgt	9	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2215900C>T	uc002cow.2	+	3	201	c.102C>T	c.(100-102)TTC>TTT	p.F34F		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	34					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						AAACGACCTTCGGACCCGCCT	0.607													0	0	0	0.001984	0	6	21										T	2215900	C	T	2215900	2	4	46	1	0	0	0	0	0	0	0	1	16443	883	31	1		1	TRAF7	16	2215900	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1352299	2215900	88138853	1327	13024										
SRRM2	23524	broad.mit.edu	37	chr16	2812535	2812535	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccagccagacgtggccgctCacgctctagaaccccagcta	9	18	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2812535C>T	uc002crk.2	+	11	2555	c.2006C>T	c.(2005-2007)TCA>TTA	p.S669L	SRRM2_uc002crj.1_Missense_Mutation_p.S573L|SRRM2_uc002crl.1_Missense_Mutation_p.S669L|SRRM2_uc010bsu.1_Missense_Mutation_p.S573L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	669	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGTGGCCGCTCACGCTCTAGA	0.617													0	0	0	0.010818	0	28	52										T	2812535	C	T	2812535	3	4	46	1	0	0	0	0	1	0	0	0	15168	838	29	1	2044	1	SRRM2	16	2812535	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	596635	2812535	87542218	1328	13025										
SRRM2	23524	broad.mit.edu	37	chr16	2818133	2818133	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggagcggcggagttcctcctCgtcgtcgtcgtcctctagct	13	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2818133C>G	uc002crk.2	+	11	8153	c.7604C>G	c.(7603-7605)TCG>TGG	p.S2535W	SRRM2_uc002crj.1_Missense_Mutation_p.S2439W|SRRM2_uc002crl.1_Missense_Mutation_p.S2535W|SRRM2_uc010bsu.1_Missense_Mutation_p.S2439W	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2535	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGTtcctcctcgtcgtcgtcg	0.408													0	0	0	0.006214	0	6	9										G	2818133	C	G	2818133	3	3	46	1	0	0	0	0	1	0	0	0	15168	893	31	1	7642	1	SRRM2	16	2818133	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5598	2818133	87536620	1329	13026										
SRRM2	23524	broad.mit.edu	37	chr16	2819183	2819183	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcttcttcttcctcctcatCttcctcctcctcgtcgtctt	2	18	6	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2819183C>G	uc002crk.2	+	12	8468	c.7919C>G	c.(7918-7920)TCT>TGT	p.S2640C		NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2640	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						tcctcctcatcttcctcctcc	0.284													0	0	0	0.00623	0	41	41										G	2819183	C	G	2819183	3	3	46	1	0	0	0	0	1	0	0	0	15168	913	32	1	7961	1	SRRM2	16	2819183	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1050	2819183	87535570	1330	13027										
MEFV	4210	broad.mit.edu	37	chr16	3293307	3293307	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cattgtaaaaggagatgcttCcaactctgtagtccacgaag	9	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:3293307C>G	uc002cun.1	-	10	2220	c.2180G>C	c.(2179-2181)GGA>GCA	p.G727A		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	727	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GGAGATGCTTCCAACTCTGTA	0.532													0	0	0	0.007413	0	20	55										G	3293307	C	G	3293307	3	3	46	1	0	0	0	0	1	0	0	0	9459	855	30	1	169	1	MEFV	16	3293307	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	474124	3293307	87061446	1331	13028										
BTBD12	84464	broad.mit.edu	37	chr16	3640211	3640211	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcttcttcgttcagtttgGatgaagatttctgagatctg	9	7	5	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:3640211G>A	uc002cvp.2	-	12	4055	c.3428C>T	c.(3427-3429)TCC>TTC	p.S1143F		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1143	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GTTCAGTTTGGATGAAGATTT	0.448								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.01441	0	65	24										A	3640211	G	A	3640211	3	1	46	1	0	0	0	0	1	0	0	0	1540	1174	41	1	2092	1	BTBD12	16	3640211	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	346904	3640211	86714542	1332	13029										
BTBD12	84464	broad.mit.edu	37	chr16	3641190	3641190	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacattgacctcaagagttCctggaaattctcggccctgc	8	14	2	2	rs143730668		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:3641190C>T	uc002cvp.2	-	12	3076	c.2449G>A	c.(2449-2451)GAA>AAA	p.E817K		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	817	Potential.|Interaction with PLK1 and TERF2-TERF2IP.|Glu-rich.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTCAAGAGTTCCTGGAAATTC	0.498								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia		OREG0032061	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.008361	0	29	82										T	3641190	C	T	3641190	3	4	46	1	0	0	0	0	1	0	0	0	1540	864	30	1	3071	1	BTBD12	16	3641190	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	979	3641190	86713563	1333	13030										
PMM2	5373	broad.mit.edu	37	chr16	8941604	8941604	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcaatgaccatgagatcttCacagaccccagaaccatggg	10	12	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:8941604C>T	uc002czf.3	+	8	733	c.663C>T	c.(661-663)TTC>TTT	p.F221F	PMM2_uc010uyf.1_RNA|PMM2_uc010uyg.1_Silent_p.F138F|PMM2_uc010uyh.1_Silent_p.F96F|PMM2_uc010buj.2_RNA|PMM2_uc010uyi.1_Silent_p.F74F|PMM2_uc002czg.1_5'Flank	NM_000303	NP_000294	O15305	PMM2_HUMAN	phosphomannomutase 2	221					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1						ATGAGATCTTCACAGACCCCA	0.597													0	0	0	0.004289	0	36	17										T	8941604	C	T	8941604	2	4	46	1	0	0	0	0	0	0	0	1	12137	825	29	1		1	PMM2	16	8941604	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5300414	8941604	81413149	1334	13031										
USP7	7874	broad.mit.edu	37	chr16	9009183	9009183	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcagaccgatagtctacttCtttacactggatataggact	7	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:9009183C>T	uc002czl.2	-	10	1205	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K	USP7_uc010uyk.1_Missense_Mutation_p.E237K|USP7_uc010uyj.1_Missense_Mutation_p.E237K|USP7_uc002czk.2_Missense_Mutation_p.E320K|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	336					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						TAGTCTACTTCTTTACACTGG	0.299													0	0	0	0.01441	0	45	32										T	9009183	C	T	9009183	3	4	46	1	0	0	0	0	1	0	0	0	17085	922	32	1	2390	1	USP7	16	9009183	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	67579	9009183	81345570	1335	13032										
TXNDC11	51061	broad.mit.edu	37	chr16	11792135	11792135	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctggttttctaaggcccacTtacagatgttctcagctgtg	9	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:11792135T>G	uc010buu.1	-	8	1096	c.1034A>C	c.(1033-1035)AAG>ACG	p.K345T	TXNDC11_uc002dbg.1_Missense_Mutation_p.K318T	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	345					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						TAAGGCCCACTTACAGATGTT	0.557													0	0	0	0.004878	0	36	16										G	11792135	T	G	11792135	3	3	46	1	0	0	0	0	1	0	0	0	16789	1609	56	5	1947	5	TXNDC11	16	11792135	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2782952	11792135	78562618	1336	13033										
RSL1D1	26156	broad.mit.edu	37	chr16	11933795	11933795	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgcctcttcttcttcctCtccttttgtttttcaaaatt	3	12	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:11933795C>G	uc002dbp.1	-	8	976	c.903G>C	c.(901-903)GAG>GAC	p.E301D	RSL1D1_uc010buv.1_Missense_Mutation_p.E300D|RSL1D1_uc010uyw.1_Missense_Mutation_p.E81D|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	301	Potential.				regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						tcttcttcctctccttttgtt	0.254													0	0	0	0.003755	0	38	65										G	11933795	C	G	11933795	3	3	46	1	0	0	0	0	1	0	0	0	13700	912	32	1	577	1	RSL1D1	16	11933795	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	141660	11933795	78420958	1337	13034										
MYH11	4629	broad.mit.edu	37	chr16	15841995	15841995	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccattgcaccgcagctgctCcagcaccaggaacgcatcca	8	18	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:15841995C>A	uc002ddy.2	-	17	2196	c.2089G>T	c.(2089-2091)GAG>TAG	p.E697*	MYH11_uc002ddv.2_Nonsense_Mutation_p.E704*|MYH11_uc002ddw.2_Nonsense_Mutation_p.E697*|MYH11_uc002ddx.2_Nonsense_Mutation_p.E704*|MYH11_uc010bvg.2_Nonsense_Mutation_p.E529*	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	697	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGCAGCTGCTCCAGCACCAGG	0.622			T	CBFB	AML								1	0	1.22574e-08	0.014323	1.26901e-08	20	8										A	15841995	C	A	15841995	4	1	46	1	0	0	0	0	0	1	0	0	10031	864	30	3	3964	3	MYH11	16	15841995	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3908200	15841995	74512758	1338	13035										
ABCC1	4363	broad.mit.edu	37	chr16	16215927	16215927	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacgagaccttgctgggggtCagcgtcattcgagccttcga	13	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:16215927C>T	uc010bvi.2	+	24	3661	c.3486C>T	c.(3484-3486)GTC>GTT	p.V1162V	ABCC1_uc010bvj.2_Silent_p.V1103V|ABCC1_uc010bvk.2_Silent_p.V1106V|ABCC1_uc010bvl.2_Silent_p.V1162V|ABCC1_uc010bvm.2_Silent_p.V1047V|ABCC1_uc002del.3_Silent_p.V1056V	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1162	Cytoplasmic.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGCTGGGGGTCAGCGTCATTC	0.607													0	0	0	0.013537	0	13	50										T	16215927	C	T	16215927	2	4	46	1	0	0	0	0	0	0	0	1	49	813	29	1		1	ABCC1	16	16215927	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	373932	16215927	74138826	1339	13036										
TMC7	79905	broad.mit.edu	37	chr16	19041668	19041668	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaatcgcctccctggccctGagccttctttggatagtgaa	9	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:19041668G>A	uc002dfq.2	+	6	964	c.834G>A	c.(832-834)CTG>CTA	p.L278L	TMC7_uc010vao.1_Silent_p.L278L|TMC7_uc002dfp.2_Silent_p.L278L|TMC7_uc010vap.1_Silent_p.L168L	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	278	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						CCCTGGCCCTGAGCCTTCTTT	0.473													0	0	0	0.01441	0	53	56										A	19041668	G	A	19041668	2	1	46	1	0	0	0	0	0	0	0	1	15987	1277	45	1		1	TMC7	16	19041668	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2825741	19041668	71313085	1340	13037										
LOC81691	81691	broad.mit.edu	37	chr16	20835811	20835811	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccaaatgtaatggttctataGcagacaatagtcctctcttt	6	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:20835811G>A	uc002dhv.2	+	7	930	c.667G>A	c.(667-669)GCA>ACA	p.A223T	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Missense_Mutation_p.A223T|LOC81691_uc002dhw.2_Intron|LOC81691_uc002dhy.3_Missense_Mutation_p.A223T	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	223						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						TGGTTCTATAGCAGACAATAG	0.348													0	0	0	0.008291	0	10	68										A	20835811	G	A	20835811	3	1	46	1	0	0	0	0	1	0	0	0	8890	971	34	2	689	2	LOC81691	16	20835811	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1794143	20835811	69518942	1341	13038										
DNAH3	55567	broad.mit.edu	37	chr16	21170741	21170741	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggggcggccagtgtgagctCgaggcgccctgtagctccca	16	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:21170741C>T	uc010vbe.1	-	1	22	c.22G>A	c.(22-24)GAG>AAG	p.E8K	TMEM159_uc002dif.3_Intron|TMEM159_uc002dig.3_Intron|TMEM159_uc010vbf.1_Intron|TMEM159_uc002dih.3_Intron	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	8	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGTGTGAGCTCGAGGCGCCCT	0.627													0	0	0	0.01441	0	44	38										T	21170741	C	T	21170741	3	4	46	1	0	0	0	0	1	0	0	0	4603	893	31	1	12575	1	DNAH3	16	21170741	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	334930	21170741	69184012	1342	13039										
ZP2	7783	broad.mit.edu	37	chr16	21214522	21214522	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctggccgaaggagaaaggtCagcttgagtgaagctaagta	14	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:21214522C>T	uc002dii.2	-	10	1023	c.1023G>A	c.(1021-1023)CTG>CTA	p.L341L	ZP2_uc010bwn.1_Silent_p.L380L	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	341	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		GGAGAAAGGTCAGCTTGAGTG	0.433													0	0	0	0.010729	0	11	53										T	21214522	C	T	21214522	2	4	46	1	0	0	0	0	0	0	0	1	18213	813	29	1		1	ZP2	16	21214522	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	43781	21214522	69140231	1343	13040										
COG7	91949	broad.mit.edu	37	chr16	23436192	23436192	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacgccgttgctgaggcagGagggcagcgagggcatgagg	19	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:23436192G>A	uc002dlo.2	-	7	1075	c.887C>T	c.(886-888)TCC>TTC	p.S296F		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	296					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		GCTGAGGCAGGAGGGCAGCGA	0.642													0	0	0	0.008871	0	19	47										A	23436192	G	A	23436192	3	1	46	1	0	0	0	0	1	0	0	0	3663	1174	41	1	1469	1	COG7	16	23436192	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2221670	23436192	66918561	1344	13041										
GGA2	23062	broad.mit.edu	37	chr16	23492071	23492071	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aactccttgggtgaggaggtCatttgcctggagaatttccg	13	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:23492071C>T	uc002dlq.2	-	10	977	c.901G>A	c.(901-903)GAC>AAC	p.D301N	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	301	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		GTGAGGAGGTCATTTGCCTGG	0.493													0	0	0	0.01441	0	265	46										T	23492071	C	T	23492071	3	4	46	1	0	0	0	0	1	0	0	0	6353	826	29	1	972	1	GGA2	16	23492071	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	55879	23492071	66862682	1345	13042										
TNRC6A	27327	broad.mit.edu	37	chr16	24802299	24802299	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taatggtaatgatacctcatCtgtatcagggtggggcgatc	12	7	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:24802299C>T	uc002dmm.2	+	6	2450	c.2336C>T	c.(2335-2337)TCT>TTT	p.S779F	TNRC6A_uc010bxs.2_Missense_Mutation_p.S526F|TNRC6A_uc010vcc.1_Missense_Mutation_p.S526F|TNRC6A_uc002dmn.2_Missense_Mutation_p.S526F|TNRC6A_uc002dmo.2_Missense_Mutation_p.S526F	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	779	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GATACCTCATCTGTATCAGGG	0.517													0	0	0	0.004482	0	9	121										T	24802299	C	T	24802299	3	4	46	1	0	0	0	0	1	0	0	0	16337	913	32	1	2358	1	TNRC6A	16	24802299	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1310228	24802299	65552454	1346	13043										
TNRC6A	27327	broad.mit.edu	37	chr16	24817006	24817006	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcaacaggtagccatgctGaaccagctatcccagctaaa	7	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:24817006G>A	uc002dmm.2	+	15	4317	c.4203G>A	c.(4201-4203)CTG>CTA	p.L1401L	TNRC6A_uc010bxs.2_Silent_p.L1148L|TNRC6A_uc002dmn.2_Silent_p.L1099L|TNRC6A_uc002dmo.2_Silent_p.L1040L|TNRC6A_uc002dmp.2_Silent_p.L2L|TNRC6A_uc002dmq.2_Silent_p.L68L	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1401					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TAGCCATGCTGAACCAGCTAT	0.403													0	0	0	0.010771	0	45	421										A	24817006	G	A	24817006	2	1	46	1	0	0	0	0	0	0	0	1	16337	1277	45	1		1	TNRC6A	16	24817006	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14707	24817006	65537747	1347	13044										
XPO6	23214	broad.mit.edu	37	chr16	28128716	28128716	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgctgcgtgttctgccggtGaacttcactgcaatactgtg	11	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:28128716G>A	uc002dpa.1	-	15	2428	c.1927C>T	c.(1927-1929)CAC>TAC	p.H643Y	XPO6_uc002dpb.1_Missense_Mutation_p.H629Y|XPO6_uc010vcp.1_Missense_Mutation_p.H643Y	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	643					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						TTCTGCCGGTGAACTTCACTG	0.488													0	0	0	0.00632	0	28	147										A	28128716	G	A	28128716	3	1	46	1	0	0	0	0	1	0	0	0	17445	1290	45	1	1490	1	XPO6	16	28128716	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3311710	28128716	62226037	1348	13045										
NFATC2IP	84901	broad.mit.edu	37	chr16	28975091	28975091	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggactgtcgggacggaagctCtccttcttctttgatgggac	13	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:28975091C>G	uc002dru.2	+	8	1182	c.1167C>G	c.(1165-1167)CTC>CTG	p.L389L	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Silent_p.L110L|NFATC2IP_uc002drv.2_Silent_p.L108L|NFATC2IP_uc010vdh.1_Silent_p.L97L	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	389	Ubiquitin-like.					cytoplasm|nucleus				ovary(1)	1						GACGGAAGCTCTCCTTCTTCT	0.547													0	0	0	0.004007	0	17	59										G	28975091	C	G	28975091	2	3	46	1	0	0	0	0	0	0	0	1	10363	900	32	1		1	NFATC2IP	16	28975091	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	846375	28975091	61379662	1349	13046										
KIF22	3835	broad.mit.edu	37	chr16	29814250	29814250	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtggaagagaaggacctaGagattgaggtacgtgtttta	14	4	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:29814250G>A	uc002dts.3	+	9	1465	c.1441G>A	c.(1441-1443)GAG>AAG	p.E481K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.E413K|KIF22_uc010vdw.1_Missense_Mutation_p.E413K|KIF22_uc010bzf.2_Missense_Mutation_p.E413K|KIF22_uc002dtt.1_5'Flank|KIF22_uc002frc.1_5'Flank	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	481	Potential.				blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						GAAGGACCTAGAGATTGAGGT	0.552													0	0	0	0.004656	0	24	28										A	29814250	G	A	29814250	3	1	46	1	0	0	0	0	1	0	0	0	8290	943	33	1	1475	1	KIF22	16	29814250	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	839159	29814250	60540503	1350	13047										
SEPT1	1731	broad.mit.edu	37	chr16	30390351	30390351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtctcacctgcggctggctCgatcgcgagccccaggccgg	15	16	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:30390351C>T	uc002dxy.2	-	10	1101	c.914G>A	c.(913-915)CGA>CAA	p.R305Q	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Missense_Mutation_p.R130Q	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	305					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			GCGGCTGGCTCGATCGCGAGC	0.682													0	0	0	0.00245	0	8	4										T	30390351	C	T	30390351	3	4	46	1	0	0	0	0	1	0	0	0	14059	884	31	1	201	1	SEPT1	16	30390351	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	576101	30390351	59964402	1351	13048										
SEPT1	1731	broad.mit.edu	37	chr16	30390418	30390418	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtagccctcgtagagcagatCgtgcgtcacctctttcaggt	11	12	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:30390418C>T	uc002dxy.2	-	10	1034	c.847G>A	c.(847-849)GAT>AAT	p.D283N	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Missense_Mutation_p.D108N	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	283					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TAGAGCAGATCGTGCGTCACC	0.667													0	0	0	0.013537	0	11	45										T	30390418	C	T	30390418	3	4	46	1	0	0	0	0	1	0	0	0	14059	884	31	1	268	1	SEPT1	16	30390418	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	67	30390418	59964335	1352	13049										
SRCAP	10847	broad.mit.edu	37	chr16	30740403	30740403	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggactgaagtcctggatttCtgtaccctgccccaacctgt	10	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:30740403C>T	uc002dze.1	+	26	6160	c.5775C>T	c.(5773-5775)TTC>TTT	p.F1925F	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.F1720F	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1925					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TCCTGGATTTCTGTACCCTGC	0.617													0	0	0	0.001855	0	12	54										T	30740403	C	T	30740403	2	4	46	1	0	0	0	0	0	0	0	1	15134	912	32	1		1	SRCAP	16	30740403	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	349985	30740403	59614350	1353	13050										
ZNF646	9726	broad.mit.edu	37	chr16	31088003	31088003	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccactccacacctccagggtGagacggtgtccactgactcc	9	17	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:31088003G>T	uc002eap.2	+	2	647	c.358G>T	c.(358-360)GAG>TAG	p.E120*	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CCTCCAGGGTGAGACGGTGTC	0.582													1	0	1.33834e-09	0.007413	1.38957e-09	20	17										T	31088003	G	T	31088003	4	4	46	1	0	0	0	0	0	1	0	0	18059	1291	45	3	360	3	ZNF646	16	31088003	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	347600	31088003	59266750	1354	13051										
ZNF646	9726	broad.mit.edu	37	chr16	31090756	31090756	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccttgggagacagcctctgCatccagggtggggaaagttt	14	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:31090756C>T	uc002eap.2	+	2	3400	c.3111C>T	c.(3109-3111)TGC>TGT	p.C1037C		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1037					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						ACAGCCTCTGCATCCAGGGTG	0.597													0	0	0	0.006999	0	37	104										T	31090756	C	T	31090756	2	4	46	1	0	0	0	0	0	0	0	1	18059	718	25	2		2	ZNF646	16	31090756	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2753	31090756	59263997	1355	13052										
SHCBP1	79801	broad.mit.edu	37	chr16	46649952	46649952	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggcaaccgatgctccttcaGatcaaggagctccttcatgc	10	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:46649952G>A	uc002eec.3	-	4	542	c.502C>T	c.(502-504)CTG>TTG	p.L168L		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	168										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				TGCTCCTTCAGATCAAGGAGC	0.517													0	0	0	0.014323	0	19	50										A	46649952	G	A	46649952	2	1	46	1	0	0	0	0	0	0	0	1	14274	933	33	1		1	SHCBP1	16	46649952	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	15559196	46649952	43704801	1356	13053										
NOD2	64127	broad.mit.edu	37	chr16	50745896	50745896	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcactggggcctgctggctGagtgccagacatctgagaag	15	10	1	3	rs143782684		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:50745896G>A	uc002egm.1	+	4	2179	c.2074G>A	c.(2074-2076)GAG>AAG	p.E692K	NOD2_uc010cbk.1_Missense_Mutation_p.E665K|NOD2_uc002egl.1_Missense_Mutation_p.E470K|NOD2_uc010cbl.1_Missense_Mutation_p.E470K|NOD2_uc010cbm.1_Missense_Mutation_p.E470K|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	692					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CCTGCTGGCTGAGTGCCAGAC	0.672													0	0	0	0.004007	0	15	34										A	50745896	G	A	50745896	3	1	46	1	0	0	0	0	1	0	0	0	10517	1291	45	1	2088	1	NOD2	16	50745896	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4095944	50745896	39608857	1357	13054										
RBL2	5934	broad.mit.edu	37	chr16	53514621	53514621	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggggagacctcattcagttCtacaacaacatctacatcaa	6	11	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:53514621C>G	uc002ehi.3	+	20	3142	c.3024C>G	c.(3022-3024)TTC>TTG	p.F1008L	RBL2_uc002ehj.2_Missense_Mutation_p.F718L|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1008	Domain B.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TCATTCAGTTCTACAACAACA	0.453													0	0	0	0.01441	0	94	45										G	53514621	C	G	53514621	3	3	46	1	0	0	0	0	1	0	0	0	13110	912	32	1	3102	1	RBL2	16	53514621	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2768725	53514621	36840132	1358	13055										
CETP	1071	broad.mit.edu	37	chr16	57016076	57016076	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccatgggcatttgattggcaGagcagctccgagtccgtcca	12	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57016076G>A	uc002eki.2	+	14	1306	c.1249_splice	c.e14-1	p.S417_splice	CETP_uc002ekj.2_Splice_Site_p.S357_splice	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma						cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						TTGATTGGCAGAGCAGCTCCG	0.577													0	0	0	0.007835	0	38	28										A	57016076	G	A	57016076	5	1	46	1	0	0	0	0	0	0	1	0	3277	956	33	1	1302	1	CETP	16	57016076	Splice_Site	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3501455	57016076	33338677	1359	13056										
NLRC5	84166	broad.mit.edu	37	chr16	57062240	57062240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaagtaaaatcactgcccGaggcatcagccacctggtga	11	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57062240G>A	uc002ekk.1	+	8	2411	c.2186G>A	c.(2185-2187)CGA>CAA	p.R729Q	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Intron|NLRC5_uc002ekl.2_Missense_Mutation_p.R534Q|NLRC5_uc002ekm.2_Missense_Mutation_p.R534Q|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	729	LRR 2.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				ATCACTGCCCGAGGCATCAGC	0.552													0	0	0	0.010771	0	43	117										A	57062240	G	A	57062240	3	1	46	1	0	0	0	0	1	0	0	0	10470	1058	37	1	2208	1	NLRC5	16	57062240	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	46164	57062240	33292513	1360	13057										
CPNE2	221184	broad.mit.edu	37	chr16	57181557	57181557	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaacctgccccccaccaactCggagcccgcctgagctccag	8	20	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57181557C>G	uc002eks.1	+	16	1863	c.1634C>G	c.(1633-1635)TCG>TGG	p.S545W	CPNE2_uc010cct.1_Missense_Mutation_p.S571W|CPNE2_uc010ccu.1_Missense_Mutation_p.S545W|CPNE2_uc002ekt.1_3'UTR	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	545										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				CCCACCAACTCGGAGCCCGCC	0.602													0	0	0	0.004482	0	8	13										G	57181557	C	G	57181557	3	3	46	1	0	0	0	0	1	0	0	0	3812	893	31	1	1692	1	CPNE2	16	57181557	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	119317	57181557	33173196	1361	13058										
CX3CL1	6376	broad.mit.edu	37	chr16	57416765	57416765	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgacgcccaggctgccaccCggaggcaggcggtggggctg	18	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57416765C>T	uc002eli.2	+	3	1082	c.1015C>T	c.(1015-1017)CGG>TGG	p.R339W		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	339	Mucin-like stalk.|Extracellular (Potential).	Cleavage; to produce soluble form (Potential).			cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GGCTGCCACCCGGAGGCAGGC	0.657													0	0	0	0.001855	0	9	26										T	57416765	C	T	57416765	3	4	46	1	0	0	0	0	1	0	0	0	4074	643	23	2	1025	2	CX3CL1	16	57416765	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	235208	57416765	32937988	1362	13059										
CDH16	1014	broad.mit.edu	37	chr16	66945993	66945993	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccaccagcttcgccacactCtgcaccaccaccaccacctc	3	24	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:66945993C>G	uc002eql.2	-	13	1672	c.1599G>C	c.(1597-1599)CAG>CAC	p.Q533H	CDH16_uc010cdy.2_Missense_Mutation_p.Q533H|CDH16_uc002eqm.2_Missense_Mutation_p.Q436H	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	533	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCGCCACACTCTGCACCACCA	0.637													0	0	0	0.001984	0	6	22										G	66945993	C	G	66945993	3	3	46	1	0	0	0	0	1	0	0	0	3101	912	32	1	914	1	CDH16	16	66945993	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9529228	66945993	23408760	1363	13060										
HSF4	3299	broad.mit.edu	37	chr16	67203215	67203215	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttccagagcggggtgagcctGagctggcggtcaaggggtta	18	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67203215G>C	uc002erl.1	+	14	2253	c.1288G>C	c.(1288-1290)GAG>CAG	p.E430Q	HSF4_uc002erm.1_Missense_Mutation_p.E400Q|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_Intron|NOL3_uc010vjc.1_5'Flank	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	430					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGGTGAGCCTGAGCTGGCGGT	0.597													0	0	0	0.001168	0	6	13										C	67203215	G	C	67203215	3	2	46	1	0	0	0	0	1	0	0	0	7398	1291	45	1	1348	1	HSF4	16	67203215	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	257222	67203215	23151538	1364	13061										
NOL3	8996	broad.mit.edu	37	chr16	67208208	67208208	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctcaccgggccagagtacGaggcattggatgcactgcct	13	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67208208G>A	uc010vjd.1	+	2	329	c.322G>A	c.(322-324)GAG>AAG	p.E108K	NOL3_uc010vjc.1_Missense_Mutation_p.E108K|NOL3_uc002erp.2_Missense_Mutation_p.E46K			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	46	CARD.				anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GCCAGAGTACGAGGCATTGGA	0.706													0	0	0	0.009096	0	4	8										A	67208208	G	A	67208208	3	1	46	1	0	0	0	0	1	0	0	0	10523	1059	37	1	138	1	NOL3	16	67208208	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4993	67208208	23146545	1365	13062										
KCTD19	146212	broad.mit.edu	37	chr16	67324826	67324826	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgctcctgggtgtgccggtCatccttgaagccggtgatgg	16	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67324826C>G	uc002esu.2	-	15	2680	c.2629G>C	c.(2629-2631)GAC>CAC	p.D877H	KCTD19_uc002est.2_Missense_Mutation_p.D649H|KCTD19_uc010vjj.1_Missense_Mutation_p.D620H	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	877						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GTGTGCCGGTCATCCTTGAAG	0.607													0	0	0	0.000602	0	5	10										G	67324826	C	G	67324826	3	3	46	1	0	0	0	0	1	0	0	0	8106	826	29	1	159	1	KCTD19	16	67324826	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	116618	67324826	23029927	1366	13063										
CENPT	80152	broad.mit.edu	37	chr16	67865789	67865789	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagctcaggaagttgcagctCcaggctataagaatggagct	13	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67865789C>G	uc002eun.3	-	8	940	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	CENPT_uc002eum.3_Missense_Mutation_p.E131Q|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_Intron|CENPT_uc010vke.1_Missense_Mutation_p.E28Q	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	131					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		AGTTGCAGCTCCAGGCTATAA	0.557													0	0	0	0.001168	0	6	13										G	67865789	C	G	67865789	3	3	46	1	0	0	0	0	1	0	0	0	3242	864	30	1	1330	1	CENPT	16	67865789	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	540963	67865789	22488964	1367	13064										
TMED6	146456	broad.mit.edu	37	chr16	69385466	69385466	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtaactgaaatagaagtatCcagtctggtgggcaaattgc	11	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:69385466C>T	uc002exc.1	-	1	224	c.191G>A	c.(190-192)GGA>GAA	p.G64E		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	64	Lumenal (Potential).|GOLD.				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						ATAGAAGTATCCAGTCTGGTG	0.483													0	0	0	0.003954	0	24	44										T	69385466	C	T	69385466	3	4	46	1	0	0	0	0	1	0	0	0	16005	855	30	1	547	1	TMED6	16	69385466	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1519677	69385466	20969287	1368	13065										
NFAT5	10725	broad.mit.edu	37	chr16	69726682	69726682	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtttctggaaatgaaacttCtacaactaccacacagcagg	7	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:69726682C>T	uc002exm.1	+	12	4108	c.2900C>T	c.(2899-2901)TCT>TTT	p.S967F	NFAT5_uc002exi.2_Missense_Mutation_p.S891F|NFAT5_uc002exj.1_Missense_Mutation_p.S891F|NFAT5_uc002exk.1_Missense_Mutation_p.S891F|NFAT5_uc002exl.1_Missense_Mutation_p.S985F|NFAT5_uc002exn.1_Missense_Mutation_p.S984F|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	967	Poly-Thr.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AATGAAACTTCTACAACTACC	0.428													0	0	0	0.006122	0	19	58										T	69726682	C	T	69726682	3	4	46	1	0	0	0	0	1	0	0	0	10360	913	32	1	3004	1	NFAT5	16	69726682	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	341216	69726682	20628071	1369	13066										
AARS	16	broad.mit.edu	37	chr16	70301626	70301626	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggatgcgacgccctctgctGagagtcttgagaaactgcac	12	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:70301626G>A	uc002eyn.1	-	9	1268	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	AARS_uc010vlu.1_Silent_p.L216L	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	386					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	GCCCTCTGCTGAGAGTCTTGA	0.517											OREG0023913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	19	37										A	70301626	G	A	70301626	2	1	46	1	0	0	0	0	0	0	0	1	19	1277	45	1		1	AARS	16	70301626	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	574944	70301626	20053127	1370	13067										
FUK	197258	broad.mit.edu	37	chr16	70504931	70504931	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgcctgctggagggccctGtccagctgggtcctgggagc	17	13	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:70504931G>A	uc002eyy.2	+	12	1184	c.1126G>A	c.(1126-1128)GTC>ATC	p.V376I	FUK_uc010cft.2_Missense_Mutation_p.V408I|FUK_uc002eyz.2_5'UTR	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	376						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GGAGGGCCCTGTCCAGCTGGG	0.682													0	0	0	0.000602	0	4	3										A	70504931	G	A	70504931	3	1	46	1	0	0	0	0	1	0	0	0	6096	1377	48	2	1168	2	FUK	16	70504931	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	203305	70504931	19849822	1371	13068										
COG4	25839	broad.mit.edu	37	chr16	70546183	70546183	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaactttcttaatccctcctCatgcaaacccagcagtggga	7	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:70546183C>T	uc002ezc.2	-	5	708	c.697G>A	c.(697-699)GAG>AAG	p.E233K	COG4_uc002ezb.2_5'Flank|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.E233K|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	229					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				AATCCCTCCTCATGCAAACCC	0.522													0	0	0	0.00278	0	22	30										T	70546183	C	T	70546183	3	4	46	1	0	0	0	0	1	0	0	0	3660	835	29	1	1732	1	COG4	16	70546183	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	41252	70546183	19808570	1372	13069										
CDH13	1012	broad.mit.edu	37	chr16	83817067	83817067	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcctgctcctcagcctcttCagcttagcttgtaagttgac	8	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:83817067C>T	uc002fgx.2	+	13	2244	c.2124C>T	c.(2122-2124)TTC>TTT	p.F708F	CDH13_uc010vns.1_Silent_p.F755F|CDH13_uc010vnt.1_Silent_p.F454F|CDH13_uc010vnu.1_Silent_p.F669F	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	708					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCAGCCTCTTCAGCTTAGCTT	0.522													0	0	0	0.010818	0	29	41										T	83817067	C	T	83817067	2	4	46	1	0	0	0	0	0	0	0	1	3099	825	29	1		1	CDH13	16	83817067	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	13270884	83817067	6537686	1373	13070										
ZZEF1	23140	broad.mit.edu	37	chr17	4045890	4045890	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgagcctccagcagctcccgGaactgctccagagtgacaga	11	15	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:4045890G>A	uc002fxe.2	-	1	364	c.300C>T	c.(298-300)TTC>TTT	p.F100F	ZZEF1_uc002fxk.1_Silent_p.F100F|CYB5D2_uc002fxm.3_5'Flank|CYB5D2_uc010cko.2_5'Flank|CYB5D2_uc002fxl.3_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	100							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCAGCTCCCGGAACTGCTCCA	0.716													0	0	0	0.013537	0	8	4										A	4045890	G	A	4045890	2	1	46	1	0	0	0	0	0	0	0	1	18252	1165	41	1		1	ZZEF1	17	4045890	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		4045890	77149320	1374	13071										
PELP1	27043	broad.mit.edu	37	chr17	4577935	4577935	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcttcccagtctgcaaactCccatcagggctcccccgcgg	10	18	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:4577935C>T	uc002fyi.3	-	13	1678	c.1452G>A	c.(1450-1452)GGG>GGA	p.G484G	PELP1_uc010vsf.1_Silent_p.G337G	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	484					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						TCTGCAAACTCCCATCAGGGC	0.577													0	0	0	0.003163	0	15	7										T	4577935	C	T	4577935	2	4	46	1	0	0	0	0	0	0	0	1	11725	842	30	1		1	PELP1	17	4577935	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	532045	4577935	76617275	1375	13072										
USP6	9098	broad.mit.edu	37	chr17	5058719	5058719	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctcgtttgtacatacagatGaggacagaactgtatttcct	8	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5058719G>A	uc002gau.1	+	31	4876	c.2646G>A	c.(2644-2646)ATG>ATA	p.M882I	USP6_uc002gav.1_Missense_Mutation_p.M882I|USP6_uc010ckz.1_Missense_Mutation_p.M565I	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	882					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						ACATACAGATGAGGACAGAAC	0.453			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								0	0	0	0.01441	0	71	30										A	5058719	G	A	5058719	3	1	46	1	0	0	0	0	1	0	0	0	17083	1290	45	1	2732	1	USP6	17	5058719	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	480784	5058719	76136491	1376	13073										
ZNF594	84622	broad.mit.edu	37	chr17	5086360	5086360	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atatggtttctctcctgtatGagttacctgatgtctgatga	9	7	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5086360G>A	uc010cla.1	-	2	1348	c.1192C>T	c.(1192-1194)CAT>TAT	p.H398Y		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	398	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCTCCTGTATGAGTTACCTGA	0.423													0	0	0	0.01441	0	263	89										A	5086360	G	A	5086360	3	1	46	1	0	0	0	0	1	0	0	0	18021	1290	45	1	1235	1	ZNF594	17	5086360	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	27641	5086360	76108850	1377	13074										
NUP88	4927	broad.mit.edu	37	chr17	5322700	5322700	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgggacagggcgggctcttCgccgccgccgctggggcccc	17	17	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5322700C>T	uc002gbo.1	-	1	297	c.271G>A	c.(271-273)GAA>AAA	p.E91K	NUP88_uc010vsx.1_Missense_Mutation_p.E91K|NUP88_uc010cle.1_Missense_Mutation_p.E91K|NUP88_uc010vsy.1_Missense_Mutation_p.E91K|RPAIN_uc010vsz.1_5'Flank|RPAIN_uc002gbp.1_5'Flank|RPAIN_uc010vta.1_5'Flank|RPAIN_uc002gbq.2_5'Flank|RPAIN_uc010vtb.1_5'Flank|RPAIN_uc002gbs.2_5'Flank|RPAIN_uc002gbt.2_5'Flank|RPAIN_uc002gbu.2_5'Flank|RPAIN_uc002gbv.2_5'Flank|RPAIN_uc002gbr.2_5'Flank|RPAIN_uc002gbw.2_5'Flank	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	91					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						GCGGGCTCTTCGCCGCCGCCG	0.602													0	0	0	0.007413	0	20	27										T	5322700	C	T	5322700	3	4	46	1	0	0	0	0	1	0	0	0	10771	893	31	1	2022	1	NUP88	17	5322700	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	236340	5322700	75872510	1378	13075										
NUP88	4927	broad.mit.edu	37	chr17	5322772	5322772	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccgtcccacaggaaaagctCtccgccgaggccaaagacca	9	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5322772C>G	uc002gbo.1	-	1	225	c.199G>C	c.(199-201)GAG>CAG	p.E67Q	NUP88_uc010vsx.1_Missense_Mutation_p.E67Q|NUP88_uc010cle.1_Missense_Mutation_p.E67Q|NUP88_uc010vsy.1_Missense_Mutation_p.E67Q|RPAIN_uc010vsz.1_5'Flank|RPAIN_uc002gbp.1_5'Flank|RPAIN_uc010vta.1_5'Flank|RPAIN_uc002gbq.2_5'Flank|RPAIN_uc010vtb.1_5'Flank|RPAIN_uc002gbs.2_5'Flank|RPAIN_uc002gbt.2_5'Flank|RPAIN_uc002gbu.2_5'Flank|RPAIN_uc002gbv.2_5'Flank|RPAIN_uc002gbr.2_5'Flank|RPAIN_uc002gbw.2_5'Flank	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	67					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						AGGAAAAGCTCTCCGCCGAGG	0.632													0	0	0	0.006999	0	37	41										G	5322772	C	G	5322772	3	3	46	1	0	0	0	0	1	0	0	0	10771	922	32	1	2094	1	NUP88	17	5322772	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	72	5322772	75872438	1379	13076										
NLRP1	22861	broad.mit.edu	37	chr17	5418329	5418329	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accgatgtcactcgggctatCagctgctctcgatactggtc	10	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5418329C>T	uc002gci.2	-	17	4722	c.4167G>A	c.(4165-4167)CTG>CTA	p.L1389L	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Silent_p.L1345L|NLRP1_uc002gcj.2_Silent_p.L1359L|NLRP1_uc002gcl.2_Silent_p.L1315L|NLRP1_uc002gch.3_Silent_p.L1345L	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1389	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CTCGGGCTATCAGCTGCTCTC	0.577													0	0	0	0.007413	0	20	19										T	5418329	C	T	5418329	2	4	46	1	0	0	0	0	0	0	0	1	10471	813	29	1		1	NLRP1	17	5418329	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	95557	5418329	75776881	1380	13077										
PITPNM3	83394	broad.mit.edu	37	chr17	6358809	6358809	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgctgcactgacatggttCtgcgcaggtggttgcgcttc	14	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:6358809C>T	uc002gdd.3	-	20	2925	c.2774G>A	c.(2773-2775)AGA>AAA	p.R925K	PITPNM3_uc010cln.2_Missense_Mutation_p.R889K|PITPNM3_uc010clm.2_Missense_Mutation_p.R408K|PITPNM3_uc002gdc.3_Missense_Mutation_p.R516K	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	925					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		TGACATGGTTCTGCGCAGGTG	0.677													0	0	0	0.004007	0	16	5										T	6358809	C	T	6358809	3	4	46	1	0	0	0	0	1	0	0	0	11952	913	32	1	154	1	PITPNM3	17	6358809	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	940480	6358809	74836401	1381	13078										
DVL2	1856	broad.mit.edu	37	chr17	7129501	7129501	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttgcttccccaccccgccGaaggctgccccctcggctgg	10	20	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7129501G>A	uc002gez.1	-	15	2176	c.1894C>T	c.(1894-1896)CGG>TGG	p.R632W	uc002gey.1_5'Flank|MIR324_hsa-mir-324|MI0000813_5'Flank|DVL2_uc010vtr.1_Missense_Mutation_p.R626W	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	632					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						CCACCCCGCCGAAGGCTGCCC	0.716													0	0	0	0.004482	0	6	31										A	7129501	G	A	7129501	3	1	46	1	0	0	0	0	1	0	0	0	4836	1057	37	1	320	1	DVL2	17	7129501	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	770692	7129501	74065709	1382	13079										
GABARAP	11337	broad.mit.edu	37	chr17	7145647	7145647	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcttctttgtacacgaacttCatcctcccgggaaccgggct	8	14	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7145647C>T	uc002gfb.2	-	1	107	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PHF23_uc002gfa.2_5'Flank|PHF23_uc010vtt.1_5'Flank|PHF23_uc010cma.2_5'Flank	NM_007278	NP_009209	O95166	GBRAP_HUMAN	GABA(A) receptor-associated protein	1	Interaction with beta-tubulin.				protein targeting|synaptic transmission	autophagic vacuole membrane|Golgi membrane|microtubule|plasma membrane	beta-tubulin binding|GABA receptor binding				0						ACACGAACTTCATCCTCCCGG	0.672													0	0	0	0.008361	0	32	7										T	7145647	C	T	7145647	3	4	46	1	0	0	0	0	1	0	0	0	6152	826	29	1	366	1	GABARAP	17	7145647	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	16146	7145647	74049563	1383	13080										
KCTD11	147040	broad.mit.edu	37	chr17	7256381	7256381	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggcacatcctcaatttcctGaggctgggccgcctggacct	11	15	1	1	rs144008002		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7256381G>A	uc002gge.3	+	1	1174	c.120G>A	c.(118-120)CTG>CTA	p.L40L	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	40	BTB.				cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				TCAATTTCCTGAGGCTGGGCC	0.667													0	0	0	0.008361	0	32	6										A	7256381	G	A	7256381	2	1	46	1	0	0	0	0	0	0	0	1	8098	1277	45	1		1	KCTD11	17	7256381	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	110734	7256381	73938829	1384	13081										
SOX15	6665	broad.mit.edu	37	chr17	7492785	7492785	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagttgtgcatcttggggttCtgctgcgccatctggcggcg	16	10	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7492785C>T	uc002ghy.1	-	2	358	c.210G>A	c.(208-210)CAG>CAA	p.Q70Q	MPDU1_uc010vuc.1_Intron|SOX15_uc002ghz.1_Silent_p.Q70Q	NM_006942	NP_008873	O60248	SOX15_HUMAN	SRY-box 15	70	HMG box.			QQ -> HE (in Ref. 5; CAA51520).	chromatin organization|male gonad development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TCTTGGGGTTCTGCTGCGCCA	0.682											OREG0024139	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	9										T	7492785	C	T	7492785	2	4	46	1	0	0	0	0	0	0	0	1	14946	912	32	1		1	SOX15	17	7492785	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	236404	7492785	73702425	1385	13082										
TP53	7157	broad.mit.edu	37	chr17	7572986	7572986	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttatggcgggaggtagactGaccctttttggacttcaggt	13	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7572986G>A	uc002gim.2	-	11	1317	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.Q243*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.Q375*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	375	Basic (repression of DNA-binding).|Interaction with CARM1.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGTAGACTGACCCTTTTTG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	68	24										A	7572986	G	A	7572986	4	1	46	1	0	0	0	0	0	1	0	0	16378	1299	45	1	62	1	TP53	17	7572986	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	80201	7572986	73622224	1386	13083										
TP53	7157	broad.mit.edu	37	chr17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acaggcacaaacacgcacctCaaagctgttccgtcccagta	7	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.014323	0	23	6										T	7577127	C	T	7577127	3	4	46	1	0	0	0	0	1	0	0	0	16378	835	29	1	475	1	TP53	17	7577127	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4141	7577127	73618083	1387	13084										
DNAH2	146754	broad.mit.edu	37	chr17	7702525	7702525	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgcagaacaacctgcacatCgtgctctgcctcagccccat	8	16	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7702525C>T	uc002giu.1	+	55	8678	c.8664C>T	c.(8662-8664)ATC>ATT	p.I2888I		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2888	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACCTGCACATCGTGCTCTGCC	0.592													0	0	0	0.007291	0	30	13										T	7702525	C	T	7702525	2	4	46	1	0	0	0	0	0	0	0	1	4602	874	31	1		1	DNAH2	17	7702525	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	125398	7702525	73492685	1388	13085										
LSMD1	84316	broad.mit.edu	37	chr17	7760451	7760451	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgaatgcgcatagtcttgttGagcagcgcctctagctgctg	12	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7760451G>A	uc002giz.2	-	2	246	c.147C>T	c.(145-147)CTC>CTT	p.L49L	LSMD1_uc002gja.2_Silent_p.L97L|CYB5D1_uc010cnn.1_5'Flank|CYB5D1_uc002gjb.3_5'Flank			Q9BRA0	LSMD1_HUMAN	RecName: Full=LSM domain-containing protein 1; AltName: Full=Phosphonoformate immuno-associated protein 2;	49	Potential.					cytoplasm|nucleus				ovary(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				TAGTCTTGTTGAGCAGCGCCT	0.642											OREG0024146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	32	82										A	7760451	G	A	7760451	2	1	46	1	0	0	0	0	0	0	0	1	9062	1277	45	1		1	LSMD1	17	7760451	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	57926	7760451	73434759	1389	13086										
CHD3	1107	broad.mit.edu	37	chr17	7792337	7792337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgatgaaggcggcagacactGtgatcctgtgggcaagaagt	15	7	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7792337G>A	uc002gje.2	+	1	169	c.19G>A	c.(19-21)GTG>ATG	p.V7M	CHD3_uc002gjd.2_Intron|CHD3_uc002gjf.2_Missense_Mutation_p.V7M|CHD3_uc002gjg.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	7					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGCAGACACTGTGATCCTGTG	0.458													0	0	0	0.01441	0	50	17										A	7792337	G	A	7792337	3	1	46	1	0	0	0	0	1	0	0	0	3326	1377	48	2	302	2	CHD3	17	7792337	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	31886	7792337	73402873	1390	13087										
MYH10	4628	broad.mit.edu	37	chr17	8508259	8508259	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcagagtaaattggaagattCttgtaagggtttataactac	9	4	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:8508259C>A	uc002gll.2	-	3	483	c.387G>T	c.(385-387)AAG>AAT	p.K129N	MYH10_uc002glm.2_Missense_Mutation_p.K129N|MYH10_uc010cnx.2_Missense_Mutation_p.K129N	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	129	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTGGAAGATTCTTGTAAGGGT	0.303													1	0	9.16793e-09	0.00499	9.49614e-09	17	65										A	8508259	C	A	8508259	3	1	46	1	0	0	0	0	1	0	0	0	10030	912	32	3	5699	3	MYH10	17	8508259	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	715922	8508259	72686951	1391	13088										
PIK3R6	146850	broad.mit.edu	37	chr17	8725949	8725949	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccctgggccctcagccacGcctctcctcctgggtgaaaa	10	18	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:8725949G>A	uc002glq.1	-	16	1983	c.1743C>T	c.(1741-1743)GGC>GGT	p.G581G	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	581					platelet activation	cytosol					0						CCTCAGCCACGCCTCTCCTCC	0.607													0	0	0	0.010729	0	11	22										A	8725949	G	A	8725949	2	1	46	1	0	0	0	0	0	0	0	1	11923	1074	38	2		2	PIK3R6	17	8725949	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	217690	8725949	72469261	1392	13089										
NTN1	9423	broad.mit.edu	37	chr17	9143161	9143161	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgggcaacgcggaggactCtccggaccagagcggcatcg	16	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:9143161C>T	uc002glw.3	+	7	1798	c.1691C>T	c.(1690-1692)TCT>TTT	p.S564F		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	564	NTR.				apoptosis|axon guidance		protein binding				0						GCGGAGGACTCTCCGGACCAG	0.637													0	0	0	0.00308	0	7	3										T	9143161	C	T	9143161	3	4	46	1	0	0	0	0	1	0	0	0	10700	913	32	1	1713	1	NTN1	17	9143161	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	417212	9143161	72052049	1393	13090										
NCOR1	9611	broad.mit.edu	37	chr17	15942956	15942956	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcaaaagaatggcctctaGagctaactgagcctgaaaga	10	9	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:15942956G>C	uc002gpo.2	-	44	6986	c.6746C>G	c.(6745-6747)TCT>TGT	p.S2249C	NCOR1_uc002gpn.2_Missense_Mutation_p.S2146C|NCOR1_uc002gpl.2_Missense_Mutation_p.S264C|NCOR1_uc002gpm.2_Missense_Mutation_p.S769C|NCOR1_uc010vwb.1_Missense_Mutation_p.S833C|NCOR1_uc010coy.2_Missense_Mutation_p.S1157C	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2249	Interaction with C1D (By similarity).|ID2 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ATGGCCTCTAGAGCTAACTGA	0.433													0	0	0	0.001984	0	7	12										C	15942956	G	C	15942956	3	2	46	1	0	0	0	0	1	0	0	0	10235	942	33	1	588	1	NCOR1	17	15942956	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6799795	15942956	65252254	1394	13091										
ULK2	9706	broad.mit.edu	37	chr17	19708077	19708077	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctctatgcgctgataattCcttatttgagtaggaactgg	10	7	1	2	rs138826045		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:19708077C>A	uc002gwm.3	-	15	1733	c.1224G>T	c.(1222-1224)AGG>AGT	p.R408S	ULK2_uc002gwn.2_Missense_Mutation_p.R408S	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	408					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GCTGATAATTCCTTATTTGAG	0.408													1	0	2.91434e-09	0.004878	3.023e-09	36	20										A	19708077	C	A	19708077	3	1	46	1	0	0	0	0	1	0	0	0	16973	854	30	3	1938	3	ULK2	17	19708077	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3765121	19708077	61487133	1395	13092										
VTN	7448	broad.mit.edu	37	chr17	26696647	26696647	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgaagggtctcaggccttGagtctatcccctcaggctta	11	11	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26696647G>C	uc002hbc.2	-	3	559	c.410C>G	c.(409-411)TCA>TGA	p.S137*	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	137					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	CTCAGGCCTTGAGTCTATCCC	0.612													0	0	0	0.008291	0	10	37										C	26696647	G	C	26696647	4	2	46	1	0	0	0	0	0	1	0	0	17234	1294	45	1	1050	1	VTN	17	26696647	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6988570	26696647	54498563	1396	13093										
KIAA0100	9703	broad.mit.edu	37	chr17	26965042	26965042	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgcttccacctgaagtcctCgaatggtacaatcaagaaaa	7	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26965042C>G	uc002hbu.2	-	14	1682	c.1583G>C	c.(1582-1584)CGA>CCA	p.R528P		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	528						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGAAGTCCTCGAATGGTACA	0.502													0	0	0	0.014323	0	22	31										G	26965042	C	G	26965042	3	3	46	1	0	0	0	0	1	0	0	0	8154	884	31	1	5228	1	KIAA0100	17	26965042	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	268395	26965042	54230168	1397	13094										
KIAA0100	9703	broad.mit.edu	37	chr17	26967622	26967622	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accacgcttgtgttctccatCttaaccttgacctggtctgg	8	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26967622C>T	uc002hbu.2	-	8	945	c.846G>A	c.(844-846)AAG>AAA	p.K282K	KIAA0100_uc002hbv.2_Silent_p.K282K|KIAA0100_uc010crr.1_Silent_p.K139K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	282						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TGTTCTCCATCTTAACCTTGA	0.463													0	0	0	0.004878	0	33	74										T	26967622	C	T	26967622	2	4	46	1	0	0	0	0	0	0	0	1	8154	912	32	1		1	KIAA0100	17	26967622	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2580	26967622	54227588	1398	13095										
KIAA0100	9703	broad.mit.edu	37	chr17	26967681	26967681	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taggccaggcagagttggctCaactaagttttctgtcacct	10	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26967681C>T	uc002hbu.2	-	8	886	c.787G>A	c.(787-789)GAG>AAG	p.E263K	KIAA0100_uc002hbv.2_Missense_Mutation_p.E263K|KIAA0100_uc010crr.1_Missense_Mutation_p.E120K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	263						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGAGTTGGCTCAACTAAGTTT	0.448													0	0	0	0.00278	0	25	43										T	26967681	C	T	26967681	3	4	46	1	0	0	0	0	1	0	0	0	8154	835	29	1	6048	1	KIAA0100	17	26967681	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	59	26967681	54227529	1399	13096										
KIAA0100	9703	broad.mit.edu	37	chr17	26967693	26967693	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttggctcaactaagttttCtgtcacctctgaaaatatga	7	8	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26967693C>T	uc002hbu.2	-	8	874	c.775G>A	c.(775-777)GAA>AAA	p.E259K	KIAA0100_uc002hbv.2_Missense_Mutation_p.E259K|KIAA0100_uc010crr.1_Missense_Mutation_p.E116K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	259						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					ACTAAGTTTTCTGTCACCTCT	0.463													0	0	0	0.014323	0	23	36										T	26967693	C	T	26967693	3	4	46	1	0	0	0	0	1	0	0	0	8154	922	32	1	6060	1	KIAA0100	17	26967693	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	12	26967693	54227517	1400	13097										
TRAF4	9618	broad.mit.edu	37	chr17	27075334	27075357	+	In_Frame_Del	DEL	GCCCGCATGATGCGGCGGCTGCTG	GCCCGCATGATGCGGCGGCTGCTG	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgtgagaataagtgtggtGcccgcatgatgcggcggctg					rs35932778	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27075334_27075357delGCCCGCATGATGCGGCGGCTGCTG	uc002hcs.2	+	5	625_648	c.517_540delGCCCGCATGATGCGGCGGCTGCTG	c.(517-540)GCCCGCATGATGCGGCGGCTGCTGdel	p.ARMMRRLL173del	TRAF4_uc002hcq.1_Intron	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	173_180	TRAF-type 2.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			TAAGTGTGGTGCCCGCATGATGCGGCGGCTGCTGGCCCAGCATG	0.576																		10	39	---	---								-	27075357	GCCCGCATGATGCGGCGGCTGCTG	-	27075334	7	5	46	1	0	1	0	1	0	0	0	0	16440	1319	46	0	535	0	TRAF4	17	27075334	In_Frame_Del	DEL	GCCCGCATGATGCGGCGGCTGCTG	TCGA-DK-A1AC-01A-11D-A13W-08	107641	27075334	54119876	1401	13098										
TRAF4	9618	broad.mit.edu	37	chr17	27075418	27075418	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgcacctactgcactaagGagttcgtctttgacaccatc	7	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27075418G>A	uc002hcs.2	+	5	709	c.601G>A	c.(601-603)GAG>AAG	p.E201K	TRAF4_uc002hcq.1_Intron	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	201	TRAF-type 2.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			CTGCACTAAGGAGTTCGTCTT	0.572													0	0	0	0.00499	0	16	19										A	27075418	G	A	27075418	3	1	46	1	0	0	0	0	1	0	0	0	16440	1175	41	1	619	1	TRAF4	17	27075418	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	84	27075418	54119792	1402	13099										
TRAF4	9618	broad.mit.edu	37	chr17	27076569	27076569	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcttcatccgtgctgctgttGaactgccccggaagatcctc	9	14	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27076569G>A	uc002hcs.2	+	7	1495	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	TRAF4_uc002hcq.1_Missense_Mutation_p.E188K	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	463					apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			TGCTGCTGTTGAACTGCCCCG	0.557													0	0	0	0.00333	0	22	52										A	27076569	G	A	27076569	3	1	46	1	0	0	0	0	1	0	0	0	16440	1291	45	1	1413	1	TRAF4	17	27076569	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1151	27076569	54118641	1403	13100										
MYO18A	399687	broad.mit.edu	37	chr17	27438549	27438549	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acccagttggtgccatggctGtggcccaggagaaagtggtg	16	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27438549G>A	uc002hdt.1	-	17	2951	c.2793C>T	c.(2791-2793)CAC>CAT	p.H931H	MYO18A_uc010wbc.1_Silent_p.H473H|MYO18A_uc002hds.2_Silent_p.H473H|MYO18A_uc010csa.1_Silent_p.H931H|MYO18A_uc002hdu.1_Silent_p.H931H|MYO18A_uc010wbd.1_Silent_p.H600H	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	931	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGCCATGGCTGTGGCCCAGGA	0.572											OREG0024287	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	29										A	27438549	G	A	27438549	2	1	46	1	0	0	0	0	0	0	0	1	10065	1368	48	2		2	MYO18A	17	27438549	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	361980	27438549	53756661	1404	13101										
BLMH	642	broad.mit.edu	37	chr17	28598396	28598396	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggagacaccaaacactaactCatggtcatagctgtaaaaag	8	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:28598396C>T	uc002hez.1	-	10	1276	c.1039G>A	c.(1039-1041)GAG>AAG	p.E347K	BLMH_uc010wbn.1_Missense_Mutation_p.E260K	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	347					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						AACACTAACTCATGGTCATAG	0.413													0	0	0	0.005443	0	27	54										T	28598396	C	T	28598396	3	4	46	1	0	0	0	0	1	0	0	0	1446	835	29	1	340	1	BLMH	17	28598396	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1159847	28598396	52596814	1405	13102										
BLMH	642	broad.mit.edu	37	chr17	28601152	28601152	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgataatttttatctttgtCtcgatattcccaggtgaatg	7	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:28601152C>T	uc002hez.1	-	7	946	c.709G>A	c.(709-711)GAC>AAC	p.D237N	BLMH_uc010wbn.1_Missense_Mutation_p.D150N	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	237					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						TTATCTTTGTCTCGATATTCC	0.438													0	0	0	0.00278	0	23	76										T	28601152	C	T	28601152	3	4	46	1	0	0	0	0	1	0	0	0	1446	913	32	1	682	1	BLMH	17	28601152	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2756	28601152	52594058	1406	13103										
CPD	1362	broad.mit.edu	37	chr17	28770948	28770948	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actggagattactggcgtctCttggttccaggaacttataa	10	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:28770948C>T	uc002hfb.1	+	11	2517	c.2502C>T	c.(2500-2502)CTC>CTT	p.L834L	CPD_uc010wbo.1_Silent_p.L587L|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	834	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						ACTGGCGTCTCTTGGTTCCAG	0.448													0	0	0	0.013114	0	45	182										T	28770948	C	T	28770948	2	4	46	1	0	0	0	0	0	0	0	1	3798	900	32	1		1	CPD	17	28770948	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	169796	28770948	52424262	1407	13104										
SUZ12	23512	broad.mit.edu	37	chr17	30302704	30302704	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaagagagtttaatggaatGattaatggagaaaccaatga	11	2	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:30302704G>A	uc002hgs.2	+	7	1017	c.795G>A	c.(793-795)ATG>ATA	p.M265I	SUZ12_uc002hgt.2_Missense_Mutation_p.M242I	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	265					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TTAATGGAATGATTAATGGAG	0.333			T	JAZF1	endometrial stromal tumours								0	0	0	0.00499	0	15	68										A	30302704	G	A	30302704	3	1	46	1	0	0	0	0	1	0	0	0	15413	1290	45	1	821	1	SUZ12	17	30302704	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1531756	30302704	50892506	1408	13105										
ZNF830	91603	broad.mit.edu	37	chr17	33288630	33288630	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actccggcagggaagcgagtGataaatcaggaagaattgcg	14	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:33288630G>A	uc002hih.3	+	1	82	c.45G>A	c.(43-45)GTG>GTA	p.V15V	CCT6B_uc002hig.2_5'Flank|CCT6B_uc010ctg.2_5'Flank|CCT6B_uc010wcc.1_5'Flank	NM_052857	NP_443089	Q96NB3	ZN830_HUMAN	coiled-coil domain containing 16	15					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)	1		Ovarian(249;0.17)				GGAAGCGAGTGATAAATCAGG	0.557													0	0	0	0.003271	0	26	64										A	33288630	G	A	33288630	2	1	46	1	0	0	0	0	0	0	0	1	18181	1277	45	1		1	ZNF830	17	33288630	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2985926	33288630	47906580	1409	13106										
SLFN11	91607	broad.mit.edu	37	chr17	33690544	33690544	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttccttgttgcttggtctCaaagaaagcctgcagatctg	9	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:33690544C>T	uc010ctp.2	-	4	725	c.283G>A	c.(283-285)GAG>AAG	p.E95K	SLFN11_uc010ctq.2_Missense_Mutation_p.E95K|SLFN11_uc002hjh.3_Missense_Mutation_p.E95K|SLFN11_uc002hjg.3_Missense_Mutation_p.E95K|SLFN11_uc010ctr.2_Missense_Mutation_p.E95K	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	95						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCTTGGTCTCAAAGAAAGCC	0.473													0	0	0	0.01441	0	56	60										T	33690544	C	T	33690544	3	4	46	1	0	0	0	0	1	0	0	0	14733	835	29	1	2438	1	SLFN11	17	33690544	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	401914	33690544	47504666	1410	13107										
LYZL6	57151	broad.mit.edu	37	chr17	34264799	34264799	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaaggttttccgagtaactCttataatcgttgcaccagta	7	9	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:34264799C>G	uc002hkj.1	-	2	411	c.261G>C	c.(259-261)AAG>AAC	p.K87N	LYZL6_uc002hkk.1_Missense_Mutation_p.K87N	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	87					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCGAGTAACTCTTATAATCGT	0.473													0	0	0	0.003755	0	23	40										G	34264799	C	G	34264799	3	3	46	1	0	0	0	0	1	0	0	0	9134	912	32	1	197	1	LYZL6	17	34264799	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	574255	34264799	46930411	1411	13108										
LHX1	3975	broad.mit.edu	37	chr17	35297719	35297719	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacaagcagctctccactggCgaggaactctacatcatcga	8	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:35297719C>T	uc002hnh.1	+	2	1299	c.303C>T	c.(301-303)GGC>GGT	p.G101G	LHX1_uc010cux.1_Silent_p.G9G	NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	101	LIM zinc-binding 2.				cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				TCTCCACTGGCGAGGAACTCT	0.522													0	0	0	0.001984	0	6	18										T	35297719	C	T	35297719	2	4	46	1	0	0	0	0	0	0	0	1	8770	755	27	2		2	LHX1	17	35297719	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1032920	35297719	45897491	1412	13109										
ACACA	31	broad.mit.edu	37	chr17	35545234	35545234	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacctgtgctgtcctggagtCagtcacttccttgtataggc	10	11	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:35545234C>T	uc002hnm.2	-	39	4839	c.4648G>A	c.(4648-4650)GAC>AAC	p.D1550N	ACACA_uc002hnk.2_Missense_Mutation_p.D1472N|ACACA_uc002hnl.2_Missense_Mutation_p.D1492N|ACACA_uc002hnn.2_Missense_Mutation_p.D1550N|ACACA_uc002hno.2_Missense_Mutation_p.D1587N|ACACA_uc010cuy.2_Missense_Mutation_p.D244N	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1550					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GTCCTGGAGTCAGTCACTTCC	0.468													0	0	0	0.005443	0	26	29										T	35545234	C	T	35545234	3	4	46	1	0	0	0	0	1	0	0	0	106	826	29	1	2464	1	ACACA	17	35545234	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	247515	35545234	45649976	1413	13110										
MRPL45	84311	broad.mit.edu	37	chr17	36476600	36476600	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttcgctgttcaagtatgatGaaccagggcaacgtgtacgg	13	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:36476600G>A	uc002hpy.2	+	6	761	c.609G>A	c.(607-609)ATG>ATA	p.M203I		NM_032351	NP_115727	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45 precursor	203					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome				0	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CAAGTATGATGAACCAGGGCA	0.507													0	0	0	0.01441	0	110	114										A	36476600	G	A	36476600	3	1	46	1	0	0	0	0	1	0	0	0	9809	1290	45	1	561	1	MRPL45	17	36476600	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	931366	36476600	44718610	1414	13111										
GPR179	440435	broad.mit.edu	37	chr17	36486038	36486038	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ataagagcggcctgcttactCaccgccttgggccggcctag	12	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:36486038C>T	uc002hpz.2	-	11	3435	c.3414G>A	c.(3412-3414)GTG>GTA	p.V1138V		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1138	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTGCTTACTCACCGCCTTGG	0.632													0	0	0	0.003271	0	35	42										T	36486038	C	T	36486038	2	4	46	1	0	0	0	0	0	0	0	1	6674	813	29	1		1	GPR179	17	36486038	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9438	36486038	44709172	1415	13112										
MED1	5469	broad.mit.edu	37	chr17	37576107	37576107	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taacaagggttccctgtagaCttcggccatctggaagagga	12	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:37576107C>G	uc002hrv.3	-	14	1372	c.1160G>C	c.(1159-1161)AGT>ACT	p.S387T	MED1_uc010wee.1_Missense_Mutation_p.S215T|MED1_uc002hru.2_Missense_Mutation_p.S387T	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	387	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TCCCTGTAGACTTCGGCCATC	0.483										HNSCC(31;0.082)			0	0	0	0.012319	0	23	68										G	37576107	C	G	37576107	3	3	46	1	0	0	0	0	1	0	0	0	9425	565	20	4	3601	4	MED1	17	37576107	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1090069	37576107	43619103	1416	13113										
WIPF2	147179	broad.mit.edu	37	chr17	38421182	38421182	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccagtctctggctcctcctCctccgccttaccgccagcct	7	21	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:38421182C>A	uc002hug.1	+	5	994	c.754C>A	c.(754-756)CCT>ACT	p.P252T	WIPF2_uc002huh.1_Missense_Mutation_p.P102T|WIPF2_uc010cww.1_Missense_Mutation_p.P102T|WIPF2_uc002hui.1_Missense_Mutation_p.P252T|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Missense_Mutation_p.P252T	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	252	Poly-Pro.					cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GGCTCCTCCTCCTCCGCCTTA	0.597										HNSCC(43;0.11)			1	0	5.34276e-22	0.01441	5.6555e-22	44	112										A	38421182	C	A	38421182	3	1	46	1	0	0	0	0	1	0	0	0	17365	855	30	3	768	3	WIPF2	17	38421182	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	845075	38421182	42774028	1417	13114										
KRT25	147183	broad.mit.edu	37	chr17	38910644	38910644	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcagtctacttacttgagtCtgaaatcatcagctgtaagc	9	9	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:38910644C>G	uc002hve.2	-	2	567	c.506G>C	c.(505-507)AGA>ACA	p.R169T		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	169	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TTACTTGAGTCTGAAATCATC	0.378													0	0	0	0.003954	0	23	54										G	38910644	C	G	38910644	3	3	46	1	0	0	0	0	1	0	0	0	8462	913	32	1	874	1	KRT25	17	38910644	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	489462	38910644	42284566	1418	13115										
KRT39	390792	broad.mit.edu	37	chr17	39116576	39116576	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgcggtatgtggtaatctCacattccagccgggacttga	12	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39116576C>G	uc002hvo.1	-	6	1210	c.1174G>C	c.(1174-1176)GAG>CAG	p.E392Q	KRT39_uc010wfm.1_Missense_Mutation_p.E125Q	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	392	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				GTGGTAATCTCACATTCCAGC	0.468													0	0	0	0.005524	0	37	90										G	39116576	C	G	39116576	3	3	46	1	0	0	0	0	1	0	0	0	8476	835	29	1	309	1	KRT39	17	39116576	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	205932	39116576	42078634	1419	13116										
KRT40	125115	broad.mit.edu	37	chr17	39137159	39137159	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgctgctgattcagctcttCtgtctgaaacacagacacca	7	12	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39137159C>G	uc010cxh.1	-	7	1014	c.853G>C	c.(853-855)GAA>CAA	p.E285Q	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	285	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				TTCAGCTCTTCTGTCTGAAAC	0.483													0	0	0	0.01441	0	69	98										G	39137159	C	G	39137159	3	3	46	1	0	0	0	0	1	0	0	0	8478	922	32	1	454	1	KRT40	17	39137159	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	20583	39137159	42058051	1420	13117										
KRTAP1-5	83895	broad.mit.edu	37	chr17	39183285	39183285	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaaatccgcagaagctagtCtggcagctgcgtggctggca	15	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39183285C>T	uc002hvu.2	-	1	170	c.123G>A	c.(121-123)CAG>CAA	p.Q41Q		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	41	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			AGAAGCTAGTCTGGCAGCTGC	0.607													0	0	0	0.008291	0	9	23										T	39183285	C	T	39183285	2	4	46	1	0	0	0	0	0	0	0	1	8504	912	32	1		1	KRTAP1-5	17	39183285	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	46126	39183285	42011925	1421	13118										
KRTAP1-5	83895	broad.mit.edu	37	chr17	39183317	39183317	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggctggcagcagctggtctCacagcagcttggctggcagc	15	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39183317C>G	uc002hvu.2	-	1	138	c.91G>C	c.(91-93)GAG>CAG	p.E31Q		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	31	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGCTGGTCTCACAGCAGCTT	0.597													0	0	0	0.00308	0	4	14										G	39183317	C	G	39183317	3	3	46	1	0	0	0	0	1	0	0	0	8504	835	29	1	437	1	KRTAP1-5	17	39183317	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	32	39183317	42011893	1422	13119										
KRTAP1-3	81850	broad.mit.edu	37	chr17	39190696	39190696	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggttgggggtgtgcagctCaccacacagcaggggggcag	18	10	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39190696C>T	uc002hvv.2	-	1	412	c.378G>A	c.(376-378)GTG>GTA	p.V126V		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	136						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GTGTGCAGCTCACCACACAGC	0.677													0	0	0	0.004007	0	16	16										T	39190696	C	T	39190696	2	4	46	1	0	0	0	0	0	0	0	1	8503	813	29	1		1	KRTAP1-3	17	39190696	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7379	39190696	42004514	1423	13120										
KRT31	3881	broad.mit.edu	37	chr17	39551521	39551521	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgtgctgggcctgcagctcGatctccagggcgttgactgt	14	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39551521G>A	uc002hwn.2	-	5	905	c.852C>T	c.(850-852)ATC>ATT	p.I284I	KRT31_uc010cxn.2_Silent_p.I284I	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	284	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				CCTGCAGCTCGATCTCCAGGG	0.607													0	0	0	0.003954	0	24	80										A	39551521	G	A	39551521	2	1	46	1	0	0	0	0	0	0	0	1	8467	1048	37	1		1	KRT31	17	39551521	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	360825	39551521	41643689	1424	13121										
NT5C3L	115024	broad.mit.edu	37	chr17	39981850	39981850	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgttgaccacatccagagtCtcgtccttctccagcacgat	7	16	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39981850C>G	uc002hyc.3	-	9	939	c.930G>C	c.(928-930)GAG>GAC	p.E310D	NT5C3L_uc002hxx.3_Missense_Mutation_p.E175D|NT5C3L_uc010wfu.1_Missense_Mutation_p.E175D|NT5C3L_uc002hyb.3_Missense_Mutation_p.E233D|NT5C3L_uc002hyd.3_Missense_Mutation_p.E233D|NT5C3L_uc002hxy.3_Missense_Mutation_p.E268D|NT5C3L_uc002hxz.3_Missense_Mutation_p.E233D|NT5C3L_uc002hya.3_3'UTR	NM_052935	NP_443167	C9JKC4	C9JKC4_HUMAN	5'-nucleotidase, cytosolic III-like	276						cytoplasm	5'-nucleotidase activity|magnesium ion binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.15)		CATCCAGAGTCTCGTCCTTCT	0.637													0	0	0	0.01441	0	51	42										G	39981850	C	G	39981850	3	3	46	1	0	0	0	0	1	0	0	0	10689	912	32	1	78	1	NT5C3L	17	39981850	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	430329	39981850	41213360	1425	13122										
KLHL10	317719	broad.mit.edu	37	chr17	40001428	40001428	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcatgaacaatgttaagatGaatgactatgtcaaagacag	8	5	2	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40001428G>A	uc010cxr.2	+	3	877	c.735G>A	c.(733-735)ATG>ATA	p.M245I	KLHL10_uc010wfv.1_Missense_Mutation_p.M239I|KLHL10_uc010wfw.1_Missense_Mutation_p.M157I	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	245						cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)				ATGTTAAGATGAATGACTATG	0.433													0	0	0	0.013537	0	13	42										A	40001428	G	A	40001428	3	1	46	1	0	0	0	0	1	0	0	0	8366	1290	45	1	745	1	KLHL10	17	40001428	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	19578	40001428	41193782	1426	13123										
ACLY	47	broad.mit.edu	37	chr17	40069977	40069977	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcagggctcacctggctgagCagccaggggtggtcctgcag	17	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40069977C>T	uc002hyg.2	-	2	313	c.150G>A	c.(148-150)CTG>CTA	p.L50L	ACLY_uc002hyh.2_Silent_p.L50L|ACLY_uc002hyi.2_Silent_p.L104L|ACLY_uc010wfx.1_Silent_p.L104L|ACLY_uc010wfy.1_Silent_p.L50L	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	50					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCTGGCTGAGCAGCCAGGGGT	0.582													0	0	0	0.00499	0	17	51										T	40069977	C	T	40069977	2	4	46	1	0	0	0	0	0	0	0	1	143	697	25	2		2	ACLY	17	40069977	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	68549	40069977	41125233	1427	13124										
ACLY	47	broad.mit.edu	37	chr17	40070105	40070105	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagttctttgcccgtctgctCtgaaattgccttggccgaca	10	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40070105C>T	uc002hyg.2	-	2	185	c.22G>A	c.(22-24)GAG>AAG	p.E8K	ACLY_uc002hyh.2_Missense_Mutation_p.E8K|ACLY_uc002hyi.2_Missense_Mutation_p.E62K|ACLY_uc010wfx.1_Missense_Mutation_p.E62K|ACLY_uc010wfy.1_Missense_Mutation_p.E8K	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	8					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCCGTCTGCTCTGAAATTGCC	0.547													0	0	0	0.004289	0	34	102										T	40070105	C	T	40070105	3	4	46	1	0	0	0	0	1	0	0	0	143	922	32	1	3395	1	ACLY	17	40070105	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	128	40070105	41125105	1428	13125										
KCNH4	23415	broad.mit.edu	37	chr17	40323937	40323937	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaccacagcactgcactgaGagtaccgctccagcttctgc	9	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40323937G>A	uc002hzb.2	-	7	1397	c.1064C>T	c.(1063-1065)TCT>TTT	p.S355F		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	355	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACTGCACTGAGAGTACCGCTC	0.527													0	0	0	0.001984	0	7	14										A	40323937	G	A	40323937	3	1	46	1	0	0	0	0	1	0	0	0	8034	942	33	1	2029	1	KCNH4	17	40323937	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	253832	40323937	40871273	1429	13126										
STAT5B	6777	broad.mit.edu	37	chr17	40384031	40384031	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacctaccatgcttggctttCaatccactgggataaataat	6	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40384031C>G	uc002hzh.2	-	2	284	c.115G>C	c.(115-117)GAA>CAA	p.E39Q	STAT5B_uc002hzi.3_Missense_Mutation_p.E39Q	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	39					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GCTTGGCTTTCAATCCACTGG	0.423													0	0	0	0.01441	0	50	55										G	40384031	C	G	40384031	3	3	46	1	0	0	0	0	1	0	0	0	15268	835	29	1	2320	1	STAT5B	17	40384031	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	60094	40384031	40811179	1430	13127										
NAGLU	4669	broad.mit.edu	37	chr17	40689536	40689536	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcaacctggcactggcctgGagcggccaggaggccatctg	14	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40689536G>A	uc002hzv.2	+	2	844	c.504G>A	c.(502-504)TGG>TGA	p.W168*		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	168						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CACTGGCCTGGAGCGGCCAGG	0.647													0	0	0	0.008291	0	11	35										A	40689536	G	A	40689536	4	1	46	1	0	0	0	0	0	1	0	0	10143	1183	41	1	510	1	NAGLU	17	40689536	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	305505	40689536	40505674	1431	13128										
PLEKHH3	79990	broad.mit.edu	37	chr17	40828484	40828484	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcgtcctcgtcctcgtccCcgtccccgctaagctcgccg	8	22	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40828484C>T	uc002iau.2	-	1	565	c.98G>A	c.(97-99)GGG>GAG	p.G33E	PLEKHH3_uc002iat.1_5'Flank|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_5'UTR|PLEKHH3_uc002iaw.2_Missense_Mutation_p.G33E	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	33					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GTCCTCGTCCCCGTCCCCGCT	0.672													0	0	0	0.009096	0	4	9										T	40828484	C	T	40828484	3	4	46	1	0	0	0	0	1	0	0	0	12078	623	22	2	2335	2	PLEKHH3	17	40828484	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	138948	40828484	40366726	1432	13129										
AARSD1	80755	broad.mit.edu	37	chr17	41116252	41116252	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggagaccacggtggtggtGaactgaacagagaggaatga	16	6	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:41116252G>A	uc002icc.2	-	2	45	c.42C>T	c.(40-42)TTC>TTT	p.F14F	AARSD1_uc002icd.2_Silent_p.F127F|AARSD1_uc002ice.2_Silent_p.F97F|AARSD1_uc002icf.2_Silent_p.F188F|AARSD1_uc010whg.1_Silent_p.F188F|AARSD1_uc010cyu.1_Silent_p.F14F	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	14					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CGGTGGTGGTGAACTGAACAG	0.468													0	0	0	0.001855	0	14	31										A	41116252	G	A	41116252	2	1	46	1	0	0	0	0	0	0	0	1	21	1281	45	1		1	AARSD1	17	41116252	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	287768	41116252	40078958	1433	13130										
ATXN7L3	56970	broad.mit.edu	37	chr17	42274334	42274334	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taggaccagtcgttgtcattGatgtcatcattatcttcttg	8	8	5	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42274334G>A	uc002iga.2	-	4	508	c.417C>T	c.(415-417)ATC>ATT	p.I139I	ATXN7L3_uc010wiv.1_5'Flank|ATXN7L3_uc002ifz.2_Silent_p.I139I	NM_001098833	NP_001092303	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3 isoform b	139					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CGTTGTCATTGATGTCATCAT	0.512													0	0	0	0.01441	0	41	97										A	42274334	G	A	42274334	2	1	46	1	0	0	0	0	0	0	0	1	1218	1280	45	1		1	ATXN7L3	17	42274334	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1158082	42274334	38920876	1434	13131										
GPATCH8	23131	broad.mit.edu	37	chr17	42513873	42513873	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccatgcgacccatgcccatGacatcatacttgacaacgat	6	14	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42513873G>C	uc002igw.1	-	4	298	c.234C>G	c.(232-234)GTC>GTG	p.V78V	GPATCH8_uc002igv.1_5'UTR|GPATCH8_uc010wiz.1_5'UTR	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	78	G-patch.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CCATGCCCATGACATCATACT	0.373													0	0	0	0.013114	0	45	60										C	42513873	G	C	42513873	2	2	46	1	0	0	0	0	0	0	0	1	6594	1277	45	1		1	GPATCH8	17	42513873	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	239539	42513873	38681337	1435	13132										
C17orf104	284071	broad.mit.edu	37	chr17	42745073	42745073	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tattcagctcagaagtatggGataattgaaaatgtaaacaa	8	4	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42745073G>C	uc010czv.2	+	5	1794	c.1794G>C	c.(1792-1794)GGG>GGC	p.G598G	C17orf104_uc002igy.1_Silent_p.G432G|C17orf104_uc002igz.3_Silent_p.G432G|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Silent_p.G432G	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	598										central_nervous_system(1)	1						AGAAGTATGGGATAATTGAAA	0.353													0	0	0	0.000602	0	5	30										C	42745073	G	C	42745073	2	2	46	1	0	0	0	0	0	0	0	1	1851	1161	41	1		1	C17orf104	17	42745073	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	231200	42745073	38450137	1436	13133										
C17orf104	284071	broad.mit.edu	37	chr17	42745351	42745351	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcaaatgggtttcccctaaGatccacccacccatttggcc	6	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42745351G>A	uc010czv.2	+	5	2072	c.2072G>A	c.(2071-2073)AGA>AAA	p.R691K	C17orf104_uc002igy.1_Missense_Mutation_p.R525K|C17orf104_uc002igz.3_Missense_Mutation_p.R525K|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Missense_Mutation_p.R525K	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	691										central_nervous_system(1)	1						TTTCCCCTAAGATCCACCCAC	0.368													0	0	0	0.000602	0	5	27										A	42745351	G	A	42745351	3	1	46	1	0	0	0	0	1	0	0	0	1851	942	33	1	2090	1	C17orf104	17	42745351	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	278	42745351	38449859	1437	13134										
HEXIM1	10614	broad.mit.edu	37	chr17	43226866	43226866	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtccgctggcggcgacttCccgccgccggcagaagtgga	15	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:43226866C>T	uc002iig.2	+	1	2183	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	103					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GCGGCGACTTCCCGCCGCCGG	0.672											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	5	8										T	43226866	C	T	43226866	2	4	46	1	0	0	0	0	0	0	0	1	7076	854	30	1		1	HEXIM1	17	43226866	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	481515	43226866	37968344	1438	13135										
PLEKHM1	9842	broad.mit.edu	37	chr17	43545870	43545870	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaggccatggagggagagcGaggcctgtggtgtggggatc	21	6	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:43545870G>A	uc002ija.2	-	5	1183	c.1013C>T	c.(1012-1014)TCG>TTG	p.S338L	PLEKHM1_uc010wjm.1_Missense_Mutation_p.S310L|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Missense_Mutation_p.S287L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	338					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					GAGGGAGAGCGAGGCCTGTGG	0.552													0	0	0	0.00632	0	28	30										A	43545870	G	A	43545870	3	1	46	1	0	0	0	0	1	0	0	0	12080	1059	37	1	2189	1	PLEKHM1	17	43545870	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	319004	43545870	37649340	1439	13136										
MAPT	4137	broad.mit.edu	37	chr17	44096051	44096072	+	Frame_Shift_Del	DEL	GTCCCTGGACAATATCACCCAC	GTCCCTGGACAATATCACCCAC	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agagtccagtcgaagattggGtccctggacaatatcaccca							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:44096051_44096072delGTCCCTGGACAATATCACCCAC	uc002ijr.3	+	13	2336_2357	c.2016_2037delGTCCCTGGACAATATCACCCAC	c.(2014-2037)GGGTCCCTGGACAATATCACCCACfs	p.G672fs	MAPT_uc010dau.2_Frame_Shift_Del_p.G690fs|MAPT_uc002ijs.3_Frame_Shift_Del_p.G355fs|MAPT_uc002ijx.3_Frame_Shift_Del_p.G326fs|MAPT_uc002ijt.3_Frame_Shift_Del_p.G297fs|MAPT_uc002iju.3_Frame_Shift_Del_p.G266fs|MAPT_uc002ijv.3_Frame_Shift_Del_p.G273fs	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	672_679	Tau/MAP 4.				cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCG	0.5																		25	116	---	---								-	44096072	GTCCCTGGACAATATCACCCAC	-	44096051	7	5	46	1	0	1	0	1	0	0	0	0	9297	1248	44	0	2120	0	MAPT	17	44096051	Frame_Shift_Del	DEL	GTCCCTGGACAATATCACCCAC	TCGA-DK-A1AC-01A-11D-A13W-08	550181	44096051	37099159	1440	13137										
OSBPL7	114881	broad.mit.edu	37	chr17	45891976	45891976	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacaggactcctcctcctctGagccctgggccaggacagat	10	15	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:45891976G>A	uc002ilx.1	-	14	1465	c.1262C>T	c.(1261-1263)TCA>TTA	p.S421L	OSBPL7_uc002ilw.1_5'UTR	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	421					lipid transport		lipid binding				0						CTCCTCCTCTGAGCCCTGGGC	0.642													0	0	0	0.001168	0	6	22										A	45891976	G	A	45891976	3	1	46	1	0	0	0	0	1	0	0	0	11282	1294	45	1	1306	1	OSBPL7	17	45891976	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1795925	45891976	35303234	1441	13138										
HOXB13	10481	broad.mit.edu	37	chr17	46805665	46805665	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgcctgggcacagggtttCagcgagctccgggacactcg	15	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:46805665C>T	uc002ioa.2	-	1	447	c.291G>A	c.(289-291)CTG>CTA	p.L97L		NM_006361	NP_006352	Q92826	HXB13_HUMAN	homeobox B13	97					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CACAGGGTTTCAGCGAGCTCC	0.672													0	0	0	0.009718	0	39	46										T	46805665	C	T	46805665	2	4	46	1	0	0	0	0	0	0	0	1	7300	813	29	1		1	HOXB13	17	46805665	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	913689	46805665	34389545	1442	13139										
SNF8	11267	broad.mit.edu	37	chr17	47022045	47022045	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccttcttcctgctcacctCtgcaagtttcttcttggcga	8	14	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:47022045C>T	uc002ioj.2	-	1	110	c.52G>A	c.(52-54)GAG>AAG	p.E18K	SNF8_uc002iok.2_Missense_Mutation_p.E18K	NM_007241	NP_009172	Q96H20	SNF8_HUMAN	EAP30 subunit of ELL complex	18					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding				0						CTGCTCACCTCTGCAAGTTTC	0.512													0	0	0	0.01441	0	48	132										T	47022045	C	T	47022045	3	4	46	1	0	0	0	0	1	0	0	0	14846	922	32	1	756	1	SNF8	17	47022045	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	216380	47022045	34173165	1443	13140										
EPN3	55040	broad.mit.edu	37	chr17	48618874	48618874	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttccaagcaaaatggcacGaaggagccagatgccctgga	12	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:48618874G>A	uc002ira.3	+	9	1839	c.1404G>A	c.(1402-1404)ACG>ACA	p.T468T	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Silent_p.T496T|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.T441T	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	468						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AAAATGGCACGAAGGAGCCAG	0.582													0	0	0	0.004482	0	9	41										A	48618874	G	A	48618874	2	1	46	1	0	0	0	0	0	0	0	1	5187	1045	37	1		1	EPN3	17	48618874	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1596829	48618874	32576336	1444	13141										
WFIKKN2	124857	broad.mit.edu	37	chr17	48917453	48917453	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcaacgtggtggtcaccaaCattgcccagctggtcatcta	11	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:48917453C>T	uc002isv.3	+	2	1498	c.804C>T	c.(802-804)AAC>AAT	p.N268N	WFIKKN2_uc010dbu.2_Silent_p.N175N	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	268	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TGGTCACCAACATTGCCCAGC	0.627													0	0	0	0.00499	0	18	34										T	48917453	C	T	48917453	2	4	46	1	0	0	0	0	0	0	0	1	17356	477	17	2		2	WFIKKN2	17	48917453	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	298579	48917453	32277757	1445	13142										
SCPEP1	59342	broad.mit.edu	37	chr17	55058443	55058443	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaattgaacttctgtttcagGagctgtcattgactggccca	9	9	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:55058443G>A	uc002iuv.3	+	2	130	c.77G>A	c.(76-78)GGA>GAA	p.G26E	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Intron	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	26					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					TCTGTTTCAGGAGCTGTCATT	0.483													0	0	0	0.012319	0	22	15										A	55058443	G	A	55058443	3	1	46	1	0	0	0	0	1	0	0	0	13935	1188	41	1	83	1	SCPEP1	17	55058443	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6140990	55058443	26136767	1446	13143										
SCPEP1	59342	broad.mit.edu	37	chr17	55074400	55074400	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggagtcgagtctagaattCacacagagccacctaggtga	11	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:55074400C>G	uc002iuv.3	+	9	917	c.864C>G	c.(862-864)TTC>TTG	p.F288L	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Missense_Mutation_p.F238L	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	288					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					GTCTAGAATTCACACAGAGCC	0.363													0	0	0	0.00245	0	13	54										G	55074400	C	G	55074400	3	3	46	1	0	0	0	0	1	0	0	0	13935	825	29	1	898	1	SCPEP1	17	55074400	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	15957	55074400	26120810	1447	13144										
MSI2	124540	broad.mit.edu	37	chr17	55693406	55693406	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccgggcccggggactgcctTacaccatggacgcgttcatg	14	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:55693406T>C	uc002iuz.1	+	9	786	c.613T>C	c.(613-615)TAC>CAC	p.Y205H	MSI2_uc010wnm.1_Missense_Mutation_p.Y183H|MSI2_uc002iva.2_Missense_Mutation_p.Y201H	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	205						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		GGGACTGCCTTACACCATGGA	0.463			T	HOXA9	CML								0	0	0	0.00623	0	36	106										C	55693406	T	C	55693406	3	2	46	1	0	0	0	0	1	0	0	0	9876	1754	61	5	697	5	MSI2	17	55693406	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	619006	55693406	25501804	1448	13145										
BZRAP1	9256	broad.mit.edu	37	chr17	56388949	56388949	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taccttctgcccatcagcgtAgatggcatagcctgtgaccc	9	14	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56388949A>C	uc002ivx.3	-	18	3935	c.3064T>G	c.(3064-3066)TAC>GAC	p.Y1022D	BZRAP1_uc010dcs.2_Missense_Mutation_p.Y962D|BZRAP1_uc010wnt.1_Missense_Mutation_p.Y1022D	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1022	Fibronectin type-III 3.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCATCAGCGTAGATGGCATAG	0.602													0	0	0	0.00245	0	15	41										C	56388949	A	C	56388949	3	2	46	1	0	0	0	0	1	0	0	0	1577	420	15	5	2565	5	BZRAP1	17	56388949	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	695543	56388949	24806261	1449	13146										
SUPT4H1	6827	broad.mit.edu	37	chr17	56428800	56428800	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtgcagtcatataccatctCtcggttacccttcatttgta	6	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56428800C>T	uc002iwe.1	-	2	206	c.139G>A	c.(139-141)GAG>AAG	p.E47K	uc010dct.1_Intron|uc010dcu.1_Intron|uc002ivz.2_Intron|uc010dcv.1_Intron|uc002iwa.2_Intron|uc002iwb.2_Intron|uc002iwc.2_Intron|SUPT4H1_uc002iwd.1_RNA	NM_003168	NP_003159	P63272	SPT4H_HUMAN	suppressor of Ty 4 homolog 1	47					chromatin remodeling|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TATACCATCTCTCGGTTACCC	0.408													0	0	0	0.004656	0	26	115										T	56428800	C	T	56428800	3	4	46	1	0	0	0	0	1	0	0	0	15395	922	32	1	230	1	SUPT4H1	17	56428800	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	39851	56428800	24766410	1450	13147										
HSF5	124535	broad.mit.edu	37	chr17	56565211	56565211	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgggcggcagggcacctccAggccggccgccagcttggcc	17	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56565211A>C	uc002iwi.1	-	1	549	c.425T>G	c.(424-426)CTG>CGG	p.L142R		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	142	By similarity.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGCACCTCCAGGCCGGCCGC	0.662													0	0	0	0.004672	0	2	0										C	56565211	A	C	56565211	3	2	46	1	0	0	0	0	1	0	0	0	7399	188	7	5	1389	5	HSF5	17	56565211	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	136411	56565211	24629999	1451	13148										
C17orf47	284083	broad.mit.edu	37	chr17	56620915	56620915	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatctgatctcactagtagtCgtaattctttggatgggctc	10	8	3	1	rs139661038		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56620915C>T	uc002iwq.1	-	1	769	c.633G>A	c.(631-633)ACG>ACA	p.T211T	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	211										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACTAGTAGTCGTAATTCTTT	0.512													0	0	0	0.01441	0	48	140										T	56620915	C	T	56620915	2	4	46	1	0	0	0	0	0	0	0	1	1858	871	31	1		1	C17orf47	17	56620915	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	55704	56620915	24574295	1452	13149										
TEX14	56155	broad.mit.edu	37	chr17	56650602	56650602	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tattttgggtgttttgcatgAagcttccttaaaagagctgt	10	5	0	2	rs140397968		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56650602A>C	uc010dcz.1	-	24	3707	c.3589T>G	c.(3589-3591)TCA>GCA	p.S1197A	TEX14_uc002iwr.1_Missense_Mutation_p.S1191A|TEX14_uc002iws.1_Missense_Mutation_p.S1151A|TEX14_uc010dda.1_Missense_Mutation_p.S931A	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1197						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTTTGCATGAAGCTTCCTTA	0.428													0	0	0	0.01441	0	60	214										C	56650602	A	C	56650602	3	2	46	1	0	0	0	0	1	0	0	0	15775	246	9	5	944	5	TEX14	17	56650602	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	29687	56650602	24544608	1453	13150										
BCAS3	54828	broad.mit.edu	37	chr17	59067592	59067592	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcccttctgggtcacccttGcatggtaattttctctgtct	8	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:59067592G>A	uc002iyv.3	+	15	1591	c.1482G>A	c.(1480-1482)TTG>TTA	p.L494L	BCAS3_uc010wow.1_Silent_p.L281L|BCAS3_uc002iyu.3_Silent_p.L494L|BCAS3_uc002iyw.3_Silent_p.L490L|BCAS3_uc002iyx.1_Silent_p.L309L|BCAS3_uc002iyy.3_Silent_p.L265L|BCAS3_uc002iyz.3_Silent_p.L48L|BCAS3_uc002iza.3_Silent_p.L48L	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	494						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GGTCACCCTTGCATGGTAATT	0.438													0	0	0	0.014323	0	21	52										A	59067592	G	A	59067592	2	1	46	1	0	0	0	0	0	0	0	1	1352	1310	46	2		2	BCAS3	17	59067592	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2416990	59067592	22127618	1454	13151										
MED13	9969	broad.mit.edu	37	chr17	60088352	60088352	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catcattagttcggatatttGaaaatctcacttgactgtct	6	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:60088352G>A	uc002izo.2	-	9	1603	c.1526C>T	c.(1525-1527)TCA>TTA	p.S509L	MED13_uc002izp.2_Missense_Mutation_p.S125L	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	509					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCGGATATTTGAAAATCTCAC	0.463													0	0	0	0.00632	0	26	86										A	60088352	G	A	60088352	3	1	46	1	0	0	0	0	1	0	0	0	9430	1294	45	1	5086	1	MED13	17	60088352	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1020760	60088352	21106858	1455	13152										
LRRC37A3	374819	broad.mit.edu	37	chr17	62892235	62892235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaggctgacctggggtctCctgctgggtcggagaagatt	17	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:62892235C>T	uc002jey.2	-	3	1672	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K	LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	381	Extracellular (Potential).					integral to membrane					0						CCTGGGGTCTCCTGCTGGGTC	0.517													0	0	0	0.01441	0	82	153										T	62892235	C	T	62892235	3	4	46	1	0	0	0	0	1	0	0	0	8993	864	30	1	3811	1	LRRC37A3	17	62892235	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2803883	62892235	18302975	1456	13153										
SLC16A6	9120	broad.mit.edu	37	chr17	66267782	66267782	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccagccaatgcgctccttCagagccatgattgcttgaat	8	13	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:66267782C>T	uc002jgz.1	-	5	707	c.519G>A	c.(517-519)CTG>CTA	p.L173L	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Silent_p.L173L	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	173	Extracellular (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	TGCGCTCCTTCAGAGCCATGA	0.448													0	0	0	0.008361	0	25	24										T	66267782	C	T	66267782	2	4	46	1	0	0	0	0	0	0	0	1	14412	813	29	1		1	SLC16A6	17	66267782	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3375547	66267782	14927428	1457	13154										
ABCA10	10349	broad.mit.edu	37	chr17	67149526	67149526	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gatgggttccccaggatgctCagcacaaagcacagctgcaa	11	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:67149526C>A	uc010dfa.1	-	35	4935	c.4056G>T	c.(4054-4056)CTG>CTT	p.L1352L	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Silent_p.L344L|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1352	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CCAGGATGCTCAGCACAAAGC	0.562													1	0	4.11147e-13	0.003755	4.30386e-13	36	110										A	67149526	C	A	67149526	2	1	46	1	0	0	0	0	0	0	0	1	29	813	29	3		3	ABCA10	17	67149526	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	881744	67149526	14045684	1458	13155										
ABCA10	10349	broad.mit.edu	37	chr17	67170479	67170479	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccacttgcgaaagatgaaTgaaagcacatatgtgaggaa	10	7	0	4	rs143503638	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:67170479T>C	uc010dfa.1	-	26	3984	c.3105A>G	c.(3103-3105)TCA>TCG	p.S1035S	ABCA10_uc010wqs.1_Silent_p.S27S|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1035					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAAAGATGAATGAAAGCACAT	0.338													0	0	0	0.003755	0	32	130										C	67170479	T	C	67170479	2	2	46	1	0	0	0	0	0	0	0	1	29	1451	51	5		5	ABCA10	17	67170479	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	20953	67170479	14024731	1459	13156										
SOX9	6662	broad.mit.edu	37	chr17	70119040	70119040	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atctcccccaacgccatcttCaaggcgctgcaggccgactc	8	18	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:70119040C>T	uc002jiw.2	+	2	984	c.612C>T	c.(610-612)TTC>TTT	p.F204F	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	204					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			ACGCCATCTTCAAGGCGCTGC	0.677													0	0	0	0.00623	0	35	39										T	70119040	C	T	70119040	2	4	46	1	0	0	0	0	0	0	0	1	14958	825	29	1		1	SOX9	17	70119040	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2948561	70119040	11076170	1460	13157										
ICT1	3396	broad.mit.edu	37	chr17	73016661	73016661	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcagttccggaatctggcaGattgcctgcagaaaattcga	10	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:73016661G>A	uc002jmm.2	+	5	447	c.445G>A	c.(445-447)GAT>AAT	p.D149N		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	149					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					GAATCTGGCAGATTGCCTGCA	0.453													0	0	0	0.004007	0	14	41										A	73016661	G	A	73016661	3	1	46	1	0	0	0	0	1	0	0	0	7488	942	33	1	463	1	ICT1	17	73016661	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2897621	73016661	8178549	1461	13158										
SRP68	6730	broad.mit.edu	37	chr17	74053483	74053483	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtaagttcttcctcctcaCctggacaatagctgcttcgt	7	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:74053483C>T	uc002jqk.1	-	8	1013	c.978_splice	c.e8+1	p.Q326_splice	SRP68_uc010wsu.1_Splice_Site_p.Q225_splice|SRP68_uc002jql.1_Splice_Site_p.Q288_splice	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa						response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TTCCTCCTCACCTGGACAATA	0.448													0	0	0	0.010504	0	20	43										T	74053483	C	T	74053483	5	4	46	1	0	0	0	0	0	0	1	0	15155	521	18	2	940	2	SRP68	17	74053483	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1036822	74053483	7141727	1462	13159										
CBX2	84733	broad.mit.edu	37	chr17	77758613	77758613	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggcggccacactgccagaGatgagcgcaggtgaggagag	17	9	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:77758613G>A	uc002jxc.2	+	5	1413	c.1371G>A	c.(1369-1371)GAG>GAA	p.E457E		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	457					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACTGCCAGAGATGAGCGCAG	0.672													0	0	0	0.001168	0	4	8										A	77758613	G	A	77758613	2	1	46	1	0	0	0	0	0	0	0	1	2718	933	33	1		1	CBX2	17	77758613	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3705130	77758613	3436597	1463	13160										
CBX8	57332	broad.mit.edu	37	chr17	77770064	77770064	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtacctttcctcaaaggctGcgagcaagcgagcatccagg	11	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:77770064G>A	uc002jxd.1	-	3	257	c.164C>T	c.(163-165)GCA>GTA	p.A55V		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	55	Chromo.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTCAAAGGCTGCGAGCAAGCG	0.532													0	0	0	0.01441	0	118	106										A	77770064	G	A	77770064	3	1	46	1	0	0	0	0	1	0	0	0	2724	1306	46	2	992	2	CBX8	17	77770064	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	11451	77770064	3425146	1464	13161										
CCDC40	55036	broad.mit.edu	37	chr17	78039319	78039319	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacgccatcagcgtggagaaGaggcgcatcatgcagcaatg	14	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:78039319G>C	uc010dht.2	+	10	1503	c.1476G>C	c.(1474-1476)AAG>AAC	p.K492N	CCDC40_uc010wub.1_Intron|CCDC40_uc002jxm.3_Missense_Mutation_p.K275N	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	492					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCGTGGAGAAGAGGCGCATCA	0.632													0	0	0	0.001855	0	14	54										C	78039319	G	C	78039319	3	2	46	1	0	0	0	0	1	0	0	0	2812	933	33	1	1514	1	CCDC40	17	78039319	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	269255	78039319	3155891	1465	13162										
ACTG1	71	broad.mit.edu	37	chr17	79478272	79478272	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaccgctcattgccaatggtGatgacctggccatcgggcag	12	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:79478272G>A	uc002kaj.1	-	3	769	c.744C>T	c.(742-744)ATC>ATT	p.I248I	ACTG1_uc002kah.1_Silent_p.I126I|ACTG1_uc002kai.1_Silent_p.I205I|ACTG1_uc002kak.1_Silent_p.I248I|ACTG1_uc010wun.1_Silent_p.I248I|ACTG1_uc002kal.1_Silent_p.I248I|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	248					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			TGCCAATGGTGATGACCTGGC	0.587													0	0	0	0.01441	0	50	75										A	79478272	G	A	79478272	2	1	46	1	0	0	0	0	0	0	0	1	196	1280	45	1		1	ACTG1	17	79478272	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1438953	79478272	1716938	1466	13163										
FSCN2	25794	broad.mit.edu	37	chr17	79503670	79503670	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggacgaagagttcaccctCaagctcatcaaccggcccat	8	14	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:79503670C>G	uc010wup.1	+	4	1269	c.1128C>G	c.(1126-1128)CTC>CTG	p.L376L	FSCN2_uc010wuo.1_Silent_p.L400L	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	376					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGTTCACCCTCAAGCTCATCA	0.701													0	0	0	0.000602	0	2	2										G	79503670	C	G	79503670	2	3	46	1	0	0	0	0	0	0	0	1	6068	813	29	1		1	FSCN2	17	79503670	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	25398	79503670	1691540	1467	13164										
P4HB	5034	broad.mit.edu	37	chr17	79803467	79803467	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcactggcaggaaagaacttGagtgtggggaagctgtgcac	16	7	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:79803467G>A	uc002kbn.1	-	9	1526	c.1329C>T	c.(1327-1329)CTC>CTT	p.L443L	P4HB_uc002kbl.1_Silent_p.L120L|P4HB_uc002kbm.1_Silent_p.L120L	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	443	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GAAAGAACTTGAGTGTGGGGA	0.622													0	0	0	0.010729	0	11	11										A	79803467	G	A	79803467	2	1	46	1	0	0	0	0	0	0	0	1	11359	1277	45	1		1	P4HB	17	79803467	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	299797	79803467	1391743	1468	13165										
DUS1L	64118	broad.mit.edu	37	chr17	80018633	80018633	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcaagtcgccggtgggcttCgctccctcctgcctggatat					rs150777513		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80018633C>T	uc002kdq.2	-	9	1385	c.966G>A	c.(964-966)GCG>GCA	p.A322A	DUS1L_uc002kdp.2_Silent_p.A191A|DUS1L_uc002kdr.2_Silent_p.A322A|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	322					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CGGTGGGCTTCGCTCCCTCCT	0.687													0	0	0	0.000602	0	5	11										T	80018633	C	T	80018633	2	4	46	1	0	0	0	0	0	0	0	1	4805	871	31	1		1	DUS1L	17	80018633	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	215166	80018633	1176577	1469	13166	62	2								
DUS1L	64118	broad.mit.edu	37	chr17	80018637	80018637	+	Missense_Mutation	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtcgccggtgggcttcgctCcctcctgcctggatatctcc							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80018637C>T	uc002kdq.2	-	9	1381	c.962G>A	c.(961-963)GGA>GAA	p.G321E	DUS1L_uc002kdp.2_Missense_Mutation_p.G190E|DUS1L_uc002kdr.2_Missense_Mutation_p.G321E|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	321					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGCTTCGCTCCCTCCTGCCT	0.692													0	0	0	0.000602	0	5	10										T	80018637	C	T	80018637	3	4	46	1	0	0	0	0	1	0	0	0	4805	855	30	1	479	1	DUS1L	17	80018637	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4	80018637	1176573	1470	13167	62	2								
DUS1L	64118	broad.mit.edu	37	chr17	80019230	80019230	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggttgtgcaggttgccctCtgtgggaggaggagcgggga	22	6	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80019230C>G	uc002kdq.2	-	7	1117	c.698_splice	c.e7-1	p.E233_splice	DUS1L_uc002kdp.2_Splice_Site_p.E102_splice|DUS1L_uc002kdr.2_Splice_Site_p.E233_splice|DUS1L_uc002kds.2_Splice_Site|DUS1L_uc002kdt.2_Splice_Site|DUS1L_uc010wvi.1_Intron	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein						tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			AGGTTGCCCTCTGTGGGAGGA	0.667													0	0	0	0.001168	0	5	24										G	80019230	C	G	80019230	5	3	46	1	0	0	0	0	0	0	1	0	4805	927	32	1	752	1	DUS1L	17	80019230	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	593	80019230	1175980	1471	13168										
WDR45L	56270	broad.mit.edu	37	chr17	80574488	80574488	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagaaactccacttggaactGaagtattttggaaggaaact	10	6	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80574488G>A	uc002kfq.2	-	9	1035	c.840C>T	c.(838-840)TTC>TTT	p.F280F	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	280					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)			ACTTGGAACTGAAGTATTTTG	0.463													0	0	0	0.005443	0	27	88										A	80574488	G	A	80574488	2	1	46	1	0	0	0	0	0	0	0	1	17295	1281	45	1		1	WDR45L	17	80574488	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	555258	80574488	620722	1472	13169										
WDR45L	56270	broad.mit.edu	37	chr17	80588887	80588889	+	In_Frame_Del	DEL	CTT	CTT	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcaacatggccaactcctcCttctagaaattctgaaatga							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80588887_80588889delCTT	uc002kfq.2	-	3	347_349	c.152_154delAAG	c.(151-156)GAAGGA>GGA	p.E51del	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	51					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)			CCAACTCCTCCTTCTAGAAATTC	0.335																		55	181	---	---								-	80588889	CTT	-	80588887	7	5	46	1	0	1	0	1	0	0	0	0	17295	690	24	0	912	0	WDR45L	17	80588887	In_Frame_Del	DEL	CTT	TCGA-DK-A1AC-01A-11D-A13W-08	14399	80588887	606323	1473	13170										
LPIN2	9663	broad.mit.edu	37	chr18	2920390	2920390	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcggaattctgctccttactGagaagggggaacacatgctc	12	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:2920390G>A	uc002klo.2	-	20	2831	c.2592C>T	c.(2590-2592)CTC>CTT	p.L864L		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	864					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GCTCCTTACTGAGAAGGGGGA	0.537													0	0	0	0.007413	0	17	28										A	2920390	G	A	2920390	2	1	46	1	0	0	0	0	0	0	0	1	8919	1277	45	1		1	LPIN2	18	2920390	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		2920390	75156858	1474	13171										
DLGAP1	9229	broad.mit.edu	37	chr18	3814113	3814113	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagccttgagatagctttctCtccgcgcagcaacttttgga	9	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:3814113C>T	uc002kmf.2	-	2	1185	c.1118G>A	c.(1117-1119)AGA>AAA	p.R373K	DLGAP1_uc010wyz.1_Missense_Mutation_p.R373K|DLGAP1_uc002kme.1_Missense_Mutation_p.R71K|DLGAP1_uc010dkn.2_Missense_Mutation_p.R71K|DLGAP1_uc010wyw.1_Missense_Mutation_p.R79K|DLGAP1_uc010wyx.1_Missense_Mutation_p.R85K|DLGAP1_uc010wyy.1_Missense_Mutation_p.R85K|DLGAP1_uc002kmg.2_Missense_Mutation_p.R71K|DLGAP1_uc002kmk.2_Missense_Mutation_p.R373K	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	373					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				ATAGCTTTCTCTCCGCGCAGC	0.507													0	0	0	0.01441	0	51	33										T	3814113	C	T	3814113	3	4	46	1	0	0	0	0	1	0	0	0	4559	913	32	1	1851	1	DLGAP1	18	3814113	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	893723	3814113	74263135	1475	13172										
KIAA0802	23255	broad.mit.edu	37	chr18	8824703	8824703	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctgcttttcccagggcggtGtccgtgtcctccatgtctga	11	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:8824703G>A	uc002knr.2	+	15	3337	c.3195G>A	c.(3193-3195)GTG>GTA	p.V1065V	KIAA0802_uc002knq.2_Silent_p.V1024V|KIAA0802_uc002kns.2_Silent_p.V405V	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1375											0						CCAGGGCGGTGTCCGTGTCCT	0.587													0	0	0	0.003163	0	15	8										A	8824703	G	A	8824703	2	1	46	1	0	0	0	0	0	0	0	1	8194	1364	48	2		2	KIAA0802	18	8824703	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5010590	8824703	69252545	1476	13173										
RALBP1	10928	broad.mit.edu	37	chr18	9522255	9522255	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacactgtagccagtttgctGaagcagtatttgcgagacct	10	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:9522255G>A	uc002kob.2	+	4	1024	c.801G>A	c.(799-801)CTG>CTA	p.L267L	RALBP1_uc002koc.2_Silent_p.L267L	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	267	Rho-GAP.				chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						CCAGTTTGCTGAAGCAGTATT	0.463													0	0	0	0.00499	0	16	53										A	9522255	G	A	9522255	2	1	46	1	0	0	0	0	0	0	0	1	13012	1277	45	1		1	RALBP1	18	9522255	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	697552	9522255	68554993	1477	13174										
RBBP8	5932	broad.mit.edu	37	chr18	20596832	20596833	+	Frame_Shift_Ins	INS	-	-	C													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcatattgaggtggttcgINSgaaaaaagaggagagaagaa							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:20596832_20596833insC	uc002ktw.2	+	17	2730_2731	c.2399_2400insC	c.(2398-2400)CGGfs	p.R800fs	RBBP8_uc002kty.2_Frame_Shift_Ins_p.R800fs|RBBP8_uc002ktz.2_Intron|RBBP8_uc002kua.2_Frame_Shift_Ins_p.R805fs|RBBP8_uc010xap.1_Frame_Shift_Ins_p.R138fs	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	800					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			GAGGTGGTTCGGAAAAAAGAGG	0.351								Direct_reversal_of_damage|Homologous_recombination										9	35	---	---								C	20596833	-	C	20596832	7	5	46	1	0	1	1	0	0	0	0	0	13105	1116	39	0	2461	0	RBBP8	18	20596832	Frame_Shift_Ins	INS	-	TCGA-DK-A1AC-01A-11D-A13W-08	11074577	20596832	57480416	1478	13175										
RBBP8	5932	broad.mit.edu	37	chr18	20606179	20606179	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacaacgcaatattttctccAaaaggcaaggagcagaagac	8	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:20606179A>C	uc002ktw.2	+	19	3001	c.2670A>C	c.(2668-2670)CCA>CCC	p.P890P	RBBP8_uc002kty.2_Silent_p.P890P|RBBP8_uc002ktz.2_Missense_Mutation_p.Q858P|RBBP8_uc002kua.2_Silent_p.P895P|RBBP8_uc010xap.1_Silent_p.P228P	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	890					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TATTTTCTCCAAAAGGCAAGG	0.348								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.012213	0	30	21										C	20606179	A	C	20606179	2	2	46	1	0	0	0	0	0	0	0	1	13105	130	5	5		5	RBBP8	18	20606179	Silent	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	9347	20606179	57471069	1479	13176										
NPC1	4864	broad.mit.edu	37	chr18	21148935	21148935	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcagctcacaaaacaggttCagtaggttataaaaacagga	9	7	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:21148935C>T	uc002kum.3	-	4	589	c.315G>A	c.(313-315)CTG>CTA	p.L105L	NPC1_uc010xba.1_5'UTR	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	105					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAACAGGTTCAGTAGGTTAT	0.368													0	0	0	0.007413	0	20	50										T	21148935	C	T	21148935	2	4	46	1	0	0	0	0	0	0	0	1	10570	813	29	1		1	NPC1	18	21148935	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	542756	21148935	56928313	1480	13177										
LAMA3	3909	broad.mit.edu	37	chr18	21479265	21479265	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctagttcttttaaagcaGatctctgggacagatggaga	10	7	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:21479265G>C	uc002kuq.2	+	47	5936	c.5850G>C	c.(5848-5850)CAG>CAC	p.Q1950H	LAMA3_uc002kur.2_Intron|LAMA3_uc002kus.3_Missense_Mutation_p.Q341H|LAMA3_uc002kut.3_Intron	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1950	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTTAAAGCAGATCTCTGGGA	0.458													0	0	0	0.013537	0	11	30										C	21479265	G	C	21479265	3	2	46	1	0	0	0	0	1	0	0	0	8607	933	33	1	6211	1	LAMA3	18	21479265	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	330330	21479265	56597983	1481	13178										
TAF4B	6875	broad.mit.edu	37	chr18	23866219	23866219	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaacacagtgaccacggtctCactgcaacctgaaaagccag	8	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:23866219C>T	uc002kvu.3	+	7	1835	c.1346C>T	c.(1345-1347)TCA>TTA	p.S449L	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.S449L	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	449					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ACCACGGTCTCACTGCAACCT	0.488													0	0	0	0.00333	0	25	37										T	23866219	C	T	23866219	3	4	46	1	0	0	0	0	1	0	0	0	15524	838	29	1	1372	1	TAF4B	18	23866219	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2386954	23866219	54211029	1482	13179										
TTR	7276	broad.mit.edu	37	chr18	29171903	29171903	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcctcctctgccttgctgGactggtatttgtgtctgagg	12	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:29171903G>A	uc002kwx.3	+	1	174	c.38G>A	c.(37-39)GGA>GAA	p.G13E		NM_000371	NP_000362	P02766	TTHY_HUMAN	transthyretin precursor	13					transport	cytoplasm	hormone activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.00523)		Diclofenac(DB00586)|Diethylstilbestrol(DB00255)|Diflunisal(DB00861)|Dimethyl sulfoxide(DB01093)|Levothyroxine(DB00451)|Liothyronine(DB00279)	TGCCTTGCTGGACTGGTATTT	0.493													0	0	0	0.006122	0	17	31										A	29171903	G	A	29171903	3	1	46	1	0	0	0	0	1	0	0	0	16735	1174	41	1	40	1	TTR	18	29171903	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5305684	29171903	48905345	1483	13180										
KIAA1012	22878	broad.mit.edu	37	chr18	29419348	29419348	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatgagactagaaagctgctCtactgatggccttgaggaaa	11	7	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:29419348C>T	uc002kxc.3	-	27	4274	c.3910G>A	c.(3910-3912)GAG>AAG	p.E1304K	KIAA1012_uc002kxb.3_Missense_Mutation_p.E1250K|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1304					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						GAAAGCTGCTCTACTGATGGC	0.348													0	0	0	0.004656	0	27	56										T	29419348	C	T	29419348	3	4	46	1	0	0	0	0	1	0	0	0	8204	922	32	1	409	1	KIAA1012	18	29419348	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	247445	29419348	48657900	1484	13181										
RNF125	54941	broad.mit.edu	37	chr18	29617112	29617112	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtattgctaccagtctaaaGaacaacaagtggacctgtcc	8	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:29617112G>A	uc002kxf.1	+	2	580	c.198G>A	c.(196-198)AAG>AAA	p.K66K		NM_017831	NP_060301	Q96EQ8	RN125_HUMAN	ring finger protein 125	66	RING-type.				negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0						CCAGTCTAAAGAACAACAAGT	0.423													0	0	0	0.01441	0	83	147										A	29617112	G	A	29617112	2	1	46	1	0	0	0	0	0	0	0	1	13434	933	33	1		1	RNF125	18	29617112	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	197764	29617112	48460136	1485	13182										
NOL4	8715	broad.mit.edu	37	chr18	31523073	31523073	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttggcggcatttctactctCactctcacaagctgaagcca	7	14	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:31523073C>T	uc010dmi.2	-	9	1727	c.1498G>A	c.(1498-1500)GAG>AAG	p.E500K	NOL4_uc010xbs.1_Missense_Mutation_p.E215K|NOL4_uc002kxr.3_Missense_Mutation_p.E272K|NOL4_uc010xbt.1_Missense_Mutation_p.E426K|NOL4_uc010dmh.2_Missense_Mutation_p.E362K|NOL4_uc010xbu.1_Missense_Mutation_p.E436K|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Missense_Mutation_p.E185K	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	500						nucleolus	RNA binding			ovary(3)	3						TTTCTACTCTCACTCTCACAA	0.428													0	0	0	0.010504	0	21	32										T	31523073	C	T	31523073	3	4	46	1	0	0	0	0	1	0	0	0	10524	835	29	1	430	1	NOL4	18	31523073	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1905961	31523073	46554175	1486	13183										
DTNA	1837	broad.mit.edu	37	chr18	32391936	32391936	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatcagatattttctcaatGatttctgactccagtggggt	8	8	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:32391936G>A	uc010dmn.1	+	5	463	c.462G>A	c.(460-462)ATG>ATA	p.M154I	DTNA_uc002kxu.2_Missense_Mutation_p.M154I|DTNA_uc010xbx.1_Missense_Mutation_p.M154I|DTNA_uc002kxv.3_Missense_Mutation_p.M154I|DTNA_uc002kxw.2_Missense_Mutation_p.M154I|DTNA_uc002kxx.2_Missense_Mutation_p.M154I|DTNA_uc010dmj.2_Missense_Mutation_p.M154I|DTNA_uc002kxz.2_Missense_Mutation_p.M154I|DTNA_uc002kxy.2_Missense_Mutation_p.M154I|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.M154I|DTNA_uc002kyb.3_Missense_Mutation_p.M154I|DTNA_uc010dmm.2_Missense_Mutation_p.M154I	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	154	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TTTTCTCAATGATTTCTGACT	0.368													0	0	0	0.00333	0	21	43										A	32391936	G	A	32391936	3	1	46	1	0	0	0	0	1	0	0	0	4788	1290	45	1	480	1	DTNA	18	32391936	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	868863	32391936	45685312	1487	13184										
ELP2	55250	broad.mit.edu	37	chr18	33722249	33722249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttttatcttactagtttcaGaaagtgctttctctctgtgg	7	7	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:33722249G>C	uc002kzk.1	+	7	604	c.594G>C	c.(592-594)CAG>CAC	p.Q198H	ELP2_uc010xcg.1_Missense_Mutation_p.Q263H|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.Q172H|ELP2_uc010xch.1_Missense_Mutation_p.Q237H|ELP2_uc002kzn.1_Missense_Mutation_p.Q172H|ELP2_uc002kzo.1_Intron	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	198	WD 4.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						ACTAGTTTCAGAAAGTGCTTT	0.398													0	0	0	0.008361	0	30	60										C	33722249	G	C	33722249	3	2	46	1	0	0	0	0	1	0	0	0	5080	933	33	1	620	1	ELP2	18	33722249	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1330313	33722249	44354999	1488	13185										
ELP2	55250	broad.mit.edu	37	chr18	33722792	33722792	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttattttttaattaggtaGagatcttttcctagcaagct	6	6	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:33722792G>C	uc002kzk.1	+	8	669	c.659G>C	c.(658-660)AGA>ACA	p.R220T	ELP2_uc010xcg.1_Missense_Mutation_p.R285T|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.R194T|ELP2_uc010xch.1_Missense_Mutation_p.R259T|ELP2_uc002kzn.1_Missense_Mutation_p.R194T|ELP2_uc002kzo.1_Missense_Mutation_p.R150T	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	220	WD 5.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TAATTAGGTAGAGATCTTTTC	0.264													0	0	0	0.003954	0	23	45										C	33722792	G	C	33722792	3	2	46	1	0	0	0	0	1	0	0	0	5080	942	33	1	689	1	ELP2	18	33722792	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	543	33722792	44354456	1489	13186										
PSTPIP2	9050	broad.mit.edu	37	chr18	43571884	43571884	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaccttgccaagttaggccCtgtagcctttcctgctggga	10	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:43571884C>T	uc002lbp.3	-	12	1000	c.904G>A	c.(904-906)GGG>AGG	p.G302R	PSTPIP2_uc002lbq.3_Silent_p.Q269Q	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	302						membrane				ovary(1)	1						AAGTTAGGCCCTGTAGCCTTT	0.408													0	0	0	0.004007	0	17	28										T	43571884	C	T	43571884	3	4	46	1	0	0	0	0	1	0	0	0	12722	681	24	2	112	2	PSTPIP2	18	43571884	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9849092	43571884	34505364	1490	13187										
ATP8B1	5205	broad.mit.edu	37	chr18	55362485	55362485	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attttatcagcatccaaaggAaaacttgtgtttctccaaaa	5	8	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:55362485A>C	uc002lgw.2	-	9	858	c.858T>G	c.(856-858)TTT>TTG	p.F286L	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	286	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				CATCCAAAGGAAAACTTGTGT	0.343									Byler_disease				0	0	0	0.012319	0	20	47										C	55362485	A	C	55362485	3	2	46	1	0	0	0	0	1	0	0	0	1194	243	9	5	2973	5	ATP8B1	18	55362485	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	11790601	55362485	22714763	1491	13188										
ATP8B1	5205	broad.mit.edu	37	chr18	55368508	55368508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccacaagcaggggcactagtGtggtgtaccaagccagggta	14	10	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:55368508G>A	uc002lgw.2	-	4	431	c.431C>T	c.(430-432)ACA>ATA	p.T144I	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	144	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GGGCACTAGTGTGGTGTACCA	0.463									Byler_disease				0	0	0	0.013537	0	12	27										A	55368508	G	A	55368508	3	1	46	1	0	0	0	0	1	0	0	0	1194	1377	48	2	3420	2	ATP8B1	18	55368508	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6023	55368508	22708740	1492	13189										
BCL2	596	broad.mit.edu	37	chr18	60985642	60985642	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accacaggtggcaccgggctGagcgcaggccccgcggcggc	17	16	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:60985642G>A	uc002lit.1	-	2	751	c.258C>T	c.(256-258)CTC>CTT	p.L86L	BCL2_uc002liu.1_Silent_p.L86L|BCL2_uc002liv.1_Silent_p.L86L	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	86					activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	GCACCGGGCTGAGCGCAggcc	0.622			T	IGH@	NHL|CLL								0	0	0	0.004672	0	3	6										A	60985642	G	A	60985642	2	1	46	1	0	0	0	0	0	0	0	1	1365	1277	45	1		1	BCL2	18	60985642	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5617134	60985642	17091606	1493	13190										
SERPINB8	5271	broad.mit.edu	37	chr18	61647081	61647081	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tattcaccgaggtttccagtCacttctcagtgaagttaaca	7	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:61647081C>T	uc002ljv.2	+	3	384	c.215C>T	c.(214-216)TCA>TTA	p.S72L	SERPINB8_uc002ljs.1_Missense_Mutation_p.S72L|SERPINB8_uc002ljt.2_Missense_Mutation_p.S72L|SERPINB8_uc002lju.2_Missense_Mutation_p.S72L|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	72					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				GGTTTCCAGTCACTTCTCAGT	0.428											OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	38	70										T	61647081	C	T	61647081	3	4	46	1	0	0	0	0	1	0	0	0	14107	838	29	1	221	1	SERPINB8	18	61647081	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	661439	61647081	16430167	1494	13191										
RTTN	25914	broad.mit.edu	37	chr18	67715352	67715352	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcttcggtcaagagaacaGaaaggaattgcaagctggca	11	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:67715352G>A	uc002lkp.2	-	40	5464	c.5396C>T	c.(5395-5397)TCT>TTT	p.S1799F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.S887F|RTTN_uc010dqp.2_Missense_Mutation_p.S51F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1799							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CAAGAGAACAGAAAGGAATTG	0.448													0	0	0	0.008871	0	20	29										A	67715352	G	A	67715352	3	1	46	1	0	0	0	0	1	0	0	0	13737	942	33	1	1324	1	RTTN	18	67715352	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6068271	67715352	10361896	1495	13192										
CNDP2	55748	broad.mit.edu	37	chr18	72167257	72167257	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acatagatgaaaatcaggatCgctacattaaggtaagggaa	10	5	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:72167257C>T	uc002llm.1	+	2	211	c.49C>T	c.(49-51)CGC>TGC	p.R17C	CNDP2_uc002lln.1_Missense_Mutation_p.R17C|CNDP2_uc002llo.2_Missense_Mutation_p.R17C	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	17						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AAATCAGGATCGCTACATTAA	0.428													0	0	0	0.013537	0	12	19										T	72167257	C	T	72167257	3	4	46	1	0	0	0	0	1	0	0	0	3594	884	31	1	51	1	CNDP2	18	72167257	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4451905	72167257	5909991	1496	13193										
NFATC1	4772	broad.mit.edu	37	chr18	77211716	77211716	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcctctggtggagaagcaGagcacggacagctatccggt	14	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:77211716G>A	uc010xfg.1	+	6	2256	c.1803G>A	c.(1801-1803)CAG>CAA	p.Q601Q	NFATC1_uc002lnc.1_Silent_p.Q601Q|NFATC1_uc010xff.1_Missense_Mutation_p.R573K|NFATC1_uc002lnd.2_Silent_p.Q601Q|NFATC1_uc002lne.2_Silent_p.Q129Q|NFATC1_uc010xfh.1_Silent_p.Q601Q|NFATC1_uc010xfi.1_Silent_p.Q588Q|NFATC1_uc010xfj.1_Silent_p.Q129Q|NFATC1_uc002lnf.2_Silent_p.Q588Q|NFATC1_uc002lng.2_Silent_p.Q588Q|NFATC1_uc010xfk.1_Silent_p.Q588Q	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	601					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		TGGAGAAGCAGAGCACGGACA	0.627													0	0	0	0.001855	0	13	21										A	77211716	G	A	77211716	2	1	46	1	0	0	0	0	0	0	0	1	10361	933	33	1		1	NFATC1	18	77211716	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	5044459	77211716	865532	1497	13194										
POLRMT	5442	broad.mit.edu	37	chr19	622259	622259	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtagcctgcaccagcatctCcgccagcagcttgcccagct	9	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:622259C>T	uc002lpf.1	-	9	1797	c.1741G>A	c.(1741-1743)GAG>AAG	p.E581K		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	581					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCAGCATCTCCGCCAGCAGC	0.672													0	0	0	0.009096	0	2	0										T	622259	C	T	622259	3	4	46	1	0	0	0	0	1	0	0	0	12238	864	30	1	2003	1	POLRMT	19	622259	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		622259	58506724	1498	13195										
POLR2E	5434	broad.mit.edu	37	chr19	1093966	1093966	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccaccagcacggtgaggtCcgtgcgccgcggccgcccct	15	18	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1093966C>T	uc002lre.3	-	2	246	c.169G>A	c.(169-171)GAC>AAC	p.D57N	POLR2E_uc010xgf.1_Intron	NM_002695	NP_002686	P19388	RPAB1_HUMAN	DNA directed RNA polymerase II polypeptide E	57					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGTGAGGTCCGTGCGCCGC	0.642													0	0	0	0.000602	0	5	13										T	1093966	C	T	1093966	3	4	46	1	0	0	0	0	1	0	0	0	12218	855	30	1	487	1	POLR2E	19	1093966	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	471707	1093966	58035017	1499	13196										
APC2	10297	broad.mit.edu	37	chr19	1453566	1453566	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggacagctttggggagctGagccgggccaccatccggct	15	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1453566G>A	uc002lsr.1	+	4	577	c.369G>A	c.(367-369)CTG>CTA	p.L123L	APC2_uc002lss.1_5'UTR|APC2_uc002lst.1_Silent_p.L123L|APC2_uc002lsu.1_Silent_p.L123L	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	123					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGGGGAGCTGAGCCGGGCCA	0.721													0	0	0	0.00308	0	8	14										A	1453566	G	A	1453566	2	1	46	1	0	0	0	0	0	0	0	1	764	1277	45	1		1	APC2	19	1453566	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	359600	1453566	57675417	1500	13197										
APC2	10297	broad.mit.edu	37	chr19	1461114	1461114	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgagggaggcgggcagcGtgactgccctggtgcagtgt	19	9	0	2	rs146990856		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1461114G>T	uc002lsr.1	+	13	1808	c.1600G>T	c.(1600-1602)GTG>TTG	p.V534L	APC2_uc002lss.1_Missense_Mutation_p.V116L|APC2_uc002lst.1_Missense_Mutation_p.V534L|APC2_uc002lsu.1_Missense_Mutation_p.V533L|uc002lsv.2_5'Flank	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	534	ARM 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGGGCAGCGTGACTGCCCT	0.647													1	0	0.000132079	0.008871	0.000134622	18	57										T	1461114	G	T	1461114	3	4	46	1	0	0	0	0	1	0	0	0	764	1145	40	4	1646	4	APC2	19	1461114	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	7548	1461114	57667869	1501	13198										
ATP8B3	148229	broad.mit.edu	37	chr19	1785654	1785654	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagttgaagagctcgtccttCtgccccaccacgtacagctc	8	15	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1785654C>G	uc002ltw.2	-	26	3441	c.3207G>C	c.(3205-3207)CAG>CAC	p.Q1069H	ATP8B3_uc002ltv.2_Missense_Mutation_p.Q1032H|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1069	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCGTCCTTCTGCCCCACCA	0.607													0	0	0	0.013537	0	12	8										G	1785654	C	G	1785654	3	3	46	1	0	0	0	0	1	0	0	0	1196	912	32	1	711	1	ATP8B3	19	1785654	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	324540	1785654	57343329	1502	13199										
DOT1L	84444	broad.mit.edu	37	chr19	2194543	2194543	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgcgagttcaggaagtggatGaaatggtatggaaaaaagca	14	4	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:2194543G>A	uc002lvb.3	+	7	654	c.618G>A	c.(616-618)ATG>ATA	p.M206I		NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	206						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGTGGATGAAATGGTATG	0.313													0	0	0	0.007413	0	17	40										A	2194543	G	A	2194543	3	1	46	1	0	0	0	0	1	0	0	0	4709	1290	45	1	644	1	DOT1L	19	2194543	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	408889	2194543	56934440	1503	13200										
DOT1L	84444	broad.mit.edu	37	chr19	2208972	2208972	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agtctgaaaaacccaaaactCagggtaagtttgtgtgtttt	9	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:2208972C>T	uc002lvb.3	+	12	1038	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	334						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCAAAACTCAGGGTAAGTT	0.443													0	0	0	0.004656	0	26	48										T	2208972	C	T	2208972	2	4	46	1	0	0	0	0	0	0	0	1	4709	813	29	1		1	DOT1L	19	2208972	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	14429	2208972	56920011	1504	13201										
ZNF555	148254	broad.mit.edu	37	chr19	2852793	2852793	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttattgacttctcaagtcttActagtcatctcagaagtcac	5	10	5	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:2852793A>G	uc002lwo.2	+	4	819	c.730A>G	c.(730-732)ACT>GCT	p.T244A	ZNF555_uc002lwn.3_Missense_Mutation_p.T243A	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	244	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAAGTCTTACTAGTCATCT	0.423													0	0	0	0.006122	0	19	54										G	2852793	A	G	2852793	3	3	46	1	0	0	0	0	1	0	0	0	17983	391	14	5	744	5	ZNF555	19	2852793	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	643821	2852793	56276190	1505	13202										
AES	166	broad.mit.edu	37	chr19	3055693	3055693	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtagggcaggacctgggcaCaaatcccgttcagccttttg	13	11	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:3055693C>G	uc002lwy.1	-	5	439	c.266G>C	c.(265-267)TGT>TCT	p.C89S	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.C89S|AES_uc002lxa.1_Missense_Mutation_p.C33S|AES_uc002lxb.1_Missense_Mutation_p.C156S|AES_uc002lxc.2_Missense_Mutation_p.C156S	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	89	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCTGGGCACAAATCCCGTT	0.642													0	0	0	0.001855	0	12	27										G	3055693	C	G	3055693	3	3	46	1	0	0	0	0	1	0	0	0	352	478	17	4	339	4	AES	19	3055693	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	202900	3055693	56073290	1506	13203										
GIPC3	126326	broad.mit.edu	37	chr19	3586625	3586625	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaggtcactaagacagagGatgctctggggctgaccatc	14	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:3586625G>A	uc002lyd.3	+	2	385	c.358G>A	c.(358-360)GAT>AAT	p.D120N		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	120	PDZ.									breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		TAAGACAGAGGATGCTCTGGG	0.632											OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	18	92										A	3586625	G	A	3586625	3	1	46	1	0	0	0	0	1	0	0	0	6394	1174	41	1	364	1	GIPC3	19	3586625	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	530932	3586625	55542358	1507	13204										
DAPK3	1613	broad.mit.edu	37	chr19	3964647	3964647	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accttcaggtcaaagtgtgcGatgcgcttagagtgcaggta	13	8	2	1	rs144975421	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:3964647G>A	uc002lzc.1	-	2	498	c.405C>T	c.(403-405)ATC>ATT	p.I135I	DAPK3_uc002lzb.1_5'Flank|DAPK3_uc002lzd.1_Silent_p.I135I	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	135	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAAGTGTGCGATGCGCTTAG	0.642													0	0	0	0.014323	0	20	59										A	3964647	G	A	3964647	2	1	46	1	0	0	0	0	0	0	0	1	4237	1048	37	1		1	DAPK3	19	3964647	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	378022	3964647	55164336	1508	13205										
CREB3L3	84699	broad.mit.edu	37	chr19	4164618	4164618	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agaaggcatcaccctgcccaCtcagctgcccctcactaagg	8	17	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:4164618C>T	uc002lzl.2	+	5	811	c.695C>T	c.(694-696)ACT>ATT	p.T232I	CREB3L3_uc002lzm.2_Missense_Mutation_p.T222I|CREB3L3_uc010xib.1_Missense_Mutation_p.T221I|CREB3L3_uc010xic.1_Missense_Mutation_p.T223I	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	232	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCTGCCCACTCAGCTGCCC	0.582													0	0	0	0.008871	0	20	26										T	4164618	C	T	4164618	3	4	46	1	0	0	0	0	1	0	0	0	3858	565	20	2	713	2	CREB3L3	19	4164618	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	199971	4164618	54964365	1509	13206										
SHD	56961	broad.mit.edu	37	chr19	4288274	4288274	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctgaacagggcggatgcaGagagcctcctgtccctctgc	12	15	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:4288274G>A	uc002lzw.2	+	5	2214	c.751G>A	c.(751-753)GAG>AAG	p.E251K	SHD_uc010dtu.2_Intron	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	251	SH2.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGGATGCAGAGAGCCTCCT	0.557													0	0	0	0.004007	0	16	42										A	4288274	G	A	4288274	3	1	46	1	0	0	0	0	1	0	0	0	14275	943	33	1	769	1	SHD	19	4288274	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	123656	4288274	54840709	1510	13207										
SHD	56961	broad.mit.edu	37	chr19	4288325	4288325	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctacctagtgcggctcagtGagaccaacccccaggactgc	11	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:4288325G>A	uc002lzw.2	+	5	2265	c.802G>A	c.(802-804)GAG>AAG	p.E268K	SHD_uc010dtu.2_Intron	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	268	SH2.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCTCAGTGAGACCAACCC	0.572													0	0	0	0.004482	0	8	26										A	4288325	G	A	4288325	3	1	46	1	0	0	0	0	1	0	0	0	14275	1291	45	1	820	1	SHD	19	4288325	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	51	4288325	54840658	1511	13208										
ACSBG2	81616	broad.mit.edu	37	chr19	6187358	6187358	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgagaccttggttaagaaGaagatccccatcatcagtaa	9	8	2	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6187358G>A	uc002mef.1	+	12	1832	c.1605G>A	c.(1603-1605)AAG>AAA	p.K535K	ACSBG2_uc002mee.1_Silent_p.K348K|ACSBG2_uc002meg.1_Silent_p.K535K|ACSBG2_uc002meh.1_Silent_p.K535K|ACSBG2_uc002mei.1_Silent_p.K485K|ACSBG2_uc010xiz.1_Silent_p.K535K	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	535					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						TGGTTAAGAAGAAGATCCCCA	0.468													0	0	0	0.00333	0	19	80										A	6187358	G	A	6187358	2	1	46	1	0	0	0	0	0	0	0	1	174	933	33	1		1	ACSBG2	19	6187358	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1899033	6187358	52941625	1512	13209										
ACER1	125981	broad.mit.edu	37	chr19	6306799	6306799	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgtcccgaggccagtagcGgactttgagggtttcacctg	13	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6306799G>A	uc002mel.2	-	6	799	c.721C>T	c.(721-723)CGC>TGC	p.R241C		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	241	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GGCCAGTAGCGGACTTTGAGG	0.572													0	0	0	0.008291	0	11	37										A	6306799	G	A	6306799	3	1	46	1	0	0	0	0	1	0	0	0	138	1116	39	2	77	2	ACER1	19	6306799	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	119441	6306799	52822184	1513	13210										
CLPP	8192	broad.mit.edu	37	chr19	6364487	6364487	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtggtgaccgcgggcctggCcatctacgacacgatgcagt	14	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6364487C>T	uc002mem.1	+	4	515	c.392C>T	c.(391-393)GCC>GTC	p.A131V	CLPP_uc002men.1_5'Flank	NM_006012	NP_006003	Q16740	CLPP_HUMAN	caseinolytic peptidase, ATP-dependent,	131					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			ovary(1)	1						GCGGGCCTGGCCATCTACGAC	0.667													0	0	0	0.000602	0	4	9										T	6364487	C	T	6364487	3	4	46	1	0	0	0	0	1	0	0	0	3552	739	26	2	406	2	CLPP	19	6364487	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	57688	6364487	52764496	1514	13211										
TRIP10	9322	broad.mit.edu	37	chr19	6746547	6746547	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttggaagaacgcagtcgtGaacttcagaaggaggttgac	14	6	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6746547G>C	uc002mfs.2	+	11	1303	c.1237G>C	c.(1237-1239)GAA>CAA	p.E413Q	TRIP10_uc010dux.1_Missense_Mutation_p.E357Q|TRIP10_uc002mfr.2_Missense_Mutation_p.E357Q|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.E176Q	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	413	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						ACGCAGTCGTGAACTTCAGAA	0.478													0	0	0	0.001984	0	7	14										C	6746547	G	C	6746547	3	2	46	1	0	0	0	0	1	0	0	0	16551	1291	45	1	1107	1	TRIP10	19	6746547	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	382060	6746547	52382436	1515	13212										
VAV1	7409	broad.mit.edu	37	chr19	6829860	6829860	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggggagactcctatgacctCaaggactttgtaaacctgca	10	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6829860C>T	uc002mfu.1	+	14	1426	c.1329C>T	c.(1327-1329)CTC>CTT	p.L443L	VAV1_uc010xjh.1_Silent_p.L411L|VAV1_uc010dva.1_Silent_p.L443L|VAV1_uc002mfv.1_Silent_p.L388L	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	443	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCTATGACCTCAAGGACTTTG	0.532													0	0	0	0.00333	0	23	86										T	6829860	C	T	6829860	2	4	46	1	0	0	0	0	0	0	0	1	17128	813	29	1		1	VAV1	19	6829860	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	83313	6829860	52299123	1516	13213										
INSR	3643	broad.mit.edu	37	chr19	7152923	7152923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atggtggagaccaggtcctcGagggcagcttcagccctgga	15	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7152923G>A	uc002mgd.1	-	10	2154	c.2045C>T	c.(2044-2046)TCG>TTG	p.S682L	INSR_uc002mge.1_Missense_Mutation_p.S682L|INSR_uc002mgf.2_Missense_Mutation_p.S682L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	682	Fibronectin type-III 1.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCAGGTCCTCGAGGGCAGCTT	0.438													0	0	0	0.014323	0	22	49										A	7152923	G	A	7152923	3	1	46	1	0	0	0	0	1	0	0	0	7773	1059	37	1	2155	1	INSR	19	7152923	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	323063	7152923	51976060	1517	13214										
INSR	3643	broad.mit.edu	37	chr19	7184523	7184523	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccacacacctgccgtccaGgtagaagttgcggcaggcca	11	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7184523G>A	uc002mgd.1	-	3	887	c.778C>T	c.(778-780)CTG>TTG	p.L260L	INSR_uc002mge.1_Silent_p.L260L|INSR_uc002mgf.2_Silent_p.L260L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	260	Cys-rich.		L -> P (in LEPRCH; Geldeimalsen).		activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGCCGTCCAGGTAGAAGTTG	0.637													0	0	0	0.009096	0	3	13										A	7184523	G	A	7184523	2	1	46	1	0	0	0	0	0	0	0	1	7773	991	35	2		2	INSR	19	7184523	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	31600	7184523	51944460	1518	13215										
ARHGEF18	23370	broad.mit.edu	37	chr19	7531822	7531822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggtggaggcgccaggcacgGaatccgatccccgtctgccc	14	15	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7531822G>A	uc002mgi.2	+	14	2612	c.2359G>A	c.(2359-2361)GAA>AAA	p.E787K	ARHGEF18_uc010xjm.1_Missense_Mutation_p.E629K|ARHGEF18_uc002mgh.2_Missense_Mutation_p.E629K|ARHGEF18_uc002mgj.1_Missense_Mutation_p.E430K	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	787					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GCCAGGCACGGAATCCGATCC	0.632													0	0	0	0.008291	0	10	57										A	7531822	G	A	7531822	3	1	46	1	0	0	0	0	1	0	0	0	901	1175	41	1	2413	1	ARHGEF18	19	7531822	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	347299	7531822	51597161	1519	13216										
C19orf59	199675	broad.mit.edu	37	chr19	7743014	7743014	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agcccagtgcaggccgccctCagactccacccaggtcccct	9	20	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7743014C>G	uc002mhh.1	+	3	234	c.209C>G	c.(208-210)TCA>TGA	p.S70*	TRAPPC5_uc002mhi.1_5'Flank|TRAPPC5_uc002mhj.1_5'Flank|TRAPPC5_uc002mhk.1_5'Flank	NM_174918	NP_777578	Q8IX19	MCEM1_HUMAN	mast cell-expressed membrane protein 1	70	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AGGCCGCCCTCAGACTCCACC	0.597											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	44	137										G	7743014	C	G	7743014	4	3	46	1	0	0	0	0	0	1	0	0	1940	838	29	1	219	1	C19orf59	19	7743014	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	211192	7743014	51385969	1520	13217										
OR7D4	125958	broad.mit.edu	37	chr19	9325375	9325375	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggagtcagagctgacggccaGaatgatgagcaggttcccca	14	10	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:9325375G>C	uc002mla.1	-	1	139	c.139C>G	c.(139-141)CTG>GTG	p.L47V		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	47	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CTGACGGCCAGAATGATGAGC	0.557													0	0	0	0.00245	0	14	56										C	9325375	G	C	9325375	3	2	46	1	0	0	0	0	1	0	0	0	11220	933	33	1	803	1	OR7D4	19	9325375	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1582361	9325375	49803608	1521	13218										
ZNF121	7675	broad.mit.edu	37	chr19	9677729	9677729	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttaaggcatgagtgttcactGaagatttctccattttccat	7	8	2	3	rs149905678		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:9677729G>A	uc010xkp.1	-	4	292	c.60C>T	c.(58-60)TTC>TTT	p.F20F	ZNF121_uc010dwt.2_Silent_p.F20F|ZNF121_uc010xkq.1_Silent_p.F20F	NM_001008727	NP_001008727	P58317	ZN121_HUMAN	zinc finger protein 121	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGTTCACTGAAGATTTCTC	0.383													0	0	0	0.014323	0	22	58										A	9677729	G	A	9677729	2	1	46	1	0	0	0	0	0	0	0	1	17716	1281	45	1		1	ZNF121	19	9677729	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	352354	9677729	49451254	1522	13219										
ZNF562	54811	broad.mit.edu	37	chr19	9763894	9763894	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atagggttttattccagtgtGagttcttacatgttgagtaa	10	4	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:9763894G>C	uc010xks.1	-	6	1175	c.1012C>G	c.(1012-1014)CAC>GAC	p.H338D	ZNF562_uc002mly.2_Missense_Mutation_p.H338D|ZNF562_uc002mlx.2_Missense_Mutation_p.H266D|ZNF562_uc010xkt.1_Missense_Mutation_p.H301D|ZNF562_uc010xku.1_Missense_Mutation_p.H269D|ZNF562_uc010xkv.1_Missense_Mutation_p.H337D|ZNF562_uc010xkw.1_Missense_Mutation_p.H222D	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	338	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTCCAGTGTGAGTTCTTACA	0.418													0	0	0	0.005524	0	37	127										C	9763894	G	C	9763894	3	2	46	1	0	0	0	0	1	0	0	0	17990	1290	45	1	272	1	ZNF562	19	9763894	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	86165	9763894	49365089	1523	13220										
TYK2	7297	broad.mit.edu	37	chr19	10488945	10488945	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgtcagcgatgactcactGaaagtgacccagggctcccc	11	14	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10488945G>A	uc002moc.3	-	3	516	c.138C>T	c.(136-138)TTC>TTT	p.F46F	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.F46F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	46	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ATGACTCACTGAAAGTGACCC	0.622													0	0	0	0.006122	0	16	28										A	10488945	G	A	10488945	2	1	46	1	0	0	0	0	0	0	0	1	16807	1281	45	1		1	TYK2	19	10488945	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	725051	10488945	48640038	1524	13221										
PDE4A	5141	broad.mit.edu	37	chr19	10571772	10571772	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtctccaaccagttcctcatCaacaccagtgagtggccctc	7	16	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10571772C>T	uc002moj.2	+	11	1566	c.1458C>T	c.(1456-1458)ATC>ATT	p.I486I	PDE4A_uc002mok.2_Silent_p.I460I|PDE4A_uc002mol.2_Silent_p.I425I|PDE4A_uc002mom.2_Silent_p.I247I|PDE4A_uc002mon.2_5'UTR|PDE4A_uc002moo.2_Silent_p.I152I	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	486	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	AGTTCCTCATCAACACCAGTG	0.647													0	0	0	0.001168	0	6	32										T	10571772	C	T	10571772	2	4	46	1	0	0	0	0	0	0	0	1	11639	816	29	1		1	PDE4A	19	10571772	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	82827	10571772	48557211	1525	13222										
CDKN2D	1032	broad.mit.edu	37	chr19	10677925	10677925	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaagtgccccggtgccatCaggcacgttgacatcagccc	12	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10677925C>T	uc002mpa.2	-	2	612	c.310G>A	c.(310-312)GAT>AAT	p.D104N	KRI1_uc002mox.1_5'Flank|KRI1_uc002moy.1_5'Flank|CDKN2D_uc002mpb.2_Missense_Mutation_p.D104N	NM_001800	NP_001791	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D	104					anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding				0			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CCGGTGCCATCAGGCACGTTG	0.597									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				0	0	0	0.004878	0	39	105										T	10677925	C	T	10677925	3	4	46	1	0	0	0	0	1	0	0	0	3166	826	29	1	194	1	CDKN2D	19	10677925	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	106153	10677925	48451058	1526	13223										
ILF3	3609	broad.mit.edu	37	chr19	10793282	10793282	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaagggggaggactcggctGaggagaccgaggcgaagcca							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10793282G>A	uc002mpn.2	+	13	1767	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	ILF3_uc002mpm.2_Missense_Mutation_p.E484K|ILF3_uc002mpl.2_Missense_Mutation_p.E484K|ILF3_uc002mpk.2_Missense_Mutation_p.E484K|ILF3_uc010xli.1_Missense_Mutation_p.E82K|ILF3_uc002mpo.2_Missense_Mutation_p.E484K|ILF3_uc002mpp.2_Missense_Mutation_p.E305K	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	484					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGACTCGGCTGAGGAGACCGA	0.647													0	0	0	0.008291	0	10	19										A	10793282	G	A	10793282	3	1	46	1	0	0	0	0	1	0	0	0	7712	1291	45	1	1496	1	ILF3	19	10793282	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	115357	10793282	48335701	1527	13224	63	3								
ILF3	3609	broad.mit.edu	37	chr19	10793285	10793285	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggggaggactcggctgagGagaccgaggcgaagccagca							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10793285G>A	uc002mpn.2	+	13	1770	c.1453G>A	c.(1453-1455)GAG>AAG	p.E485K	ILF3_uc002mpm.2_Missense_Mutation_p.E485K|ILF3_uc002mpl.2_Missense_Mutation_p.E485K|ILF3_uc002mpk.2_Missense_Mutation_p.E485K|ILF3_uc010xli.1_Missense_Mutation_p.E83K|ILF3_uc002mpo.2_Missense_Mutation_p.E485K|ILF3_uc002mpp.2_Missense_Mutation_p.E306K	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	485					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CTCGGCTGAGGAGACCGAGGC	0.647													0	0	0	0.008291	0	10	19										A	10793285	G	A	10793285	3	1	46	1	0	0	0	0	1	0	0	0	7712	1175	41	1	1499	1	ILF3	19	10793285	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3	10793285	48335698	1528	13225	63	3								
ILF3	3609	broad.mit.edu	37	chr19	10793287	10793287	+	Silent	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggaggactcggctgaggaGaccgaggcgaagccagcagt							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10793287G>A	uc002mpn.2	+	13	1772	c.1455G>A	c.(1453-1455)GAG>GAA	p.E485E	ILF3_uc002mpm.2_Silent_p.E485E|ILF3_uc002mpl.2_Silent_p.E485E|ILF3_uc002mpk.2_Silent_p.E485E|ILF3_uc010xli.1_Silent_p.E83E|ILF3_uc002mpo.2_Silent_p.E485E|ILF3_uc002mpp.2_Silent_p.E306E	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	485					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CGGCTGAGGAGACCGAGGCGA	0.647													0	0	0	0.008291	0	10	19										A	10793287	G	A	10793287	2	1	46	1	0	0	0	0	0	0	0	1	7712	933	33	1		1	ILF3	19	10793287	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2	10793287	48335696	1529	13226	63	3								
C19orf52	90580	broad.mit.edu	37	chr19	11040318	11040318	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggtcttgcagaaggagaaGaaggacaggctcgccctgag	15	9	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11040318G>A	uc002mqd.1	+	2	798	c.723G>A	c.(721-723)AAG>AAA	p.K241K	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	241											0						AGAAGGAGAAGAAGGACAGGC	0.637													0	0	0	0.003163	0	15	11										A	11040318	G	A	11040318	2	1	46	1	0	0	0	0	0	0	0	1	1934	933	33	1		1	C19orf52	19	11040318	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	247031	11040318	48088665	1530	13227										
EPOR	2057	broad.mit.edu	37	chr19	11493835	11493835	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgctcgccgcttcctcccaGaaacacaccaagtcctccaa	6	19	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11493835G>A	uc002mrj.1	-	2	325	c.189C>T	c.(187-189)TTC>TTT	p.F63F	EPOR_uc002mrh.2_5'Flank|EPOR_uc002mri.2_5'UTR|EPOR_uc002mrk.1_5'UTR|EPOR_uc002mrl.1_RNA|EPOR_uc010xlx.1_RNA|EPOR_uc010xly.1_5'UTR|RGL3_uc002mrn.2_3'UTR|RGL3_uc002mrm.2_3'UTR	NM_000121	NP_000112	P19235	EPOR_HUMAN	erythropoietin receptor precursor	63	Extracellular (Potential).					extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CTTCCTCCCAGAAACACACCA	0.682													0	0	0	0.001984	0	7	21										A	11493835	G	A	11493835	2	1	46	1	0	0	0	0	0	0	0	1	5189	933	33	1		1	EPOR	19	11493835	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	453517	11493835	47635148	1531	13228										
CCDC151	115948	broad.mit.edu	37	chr19	11541826	11541826	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgagagctctcaaaaaaagCcttccggtcaccctctggca	8	14	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11541826C>T	uc002mrs.2	-	2	402	c.259G>A	c.(259-261)GCT>ACT	p.A87T	CCDC151_uc002mrr.2_Missense_Mutation_p.A22T|CCDC151_uc010dxz.2_Missense_Mutation_p.A87T	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	87										ovary(1)	1						TCAAAAAAAGCCTTCCGGTCA	0.522													0	0	0	0.012213	0	31	132										T	11541826	C	T	11541826	3	4	46	1	0	0	0	0	1	0	0	0	2786	739	26	2	1576	2	CCDC151	19	11541826	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	47991	11541826	47587157	1532	13229										
ACP5	54	broad.mit.edu	37	chr19	11687879	11687879	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgggcacagacctggaacCtcttgtcattgatgtcttgc	11	10	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11687879C>G	uc002msg.3	-	2	400	c.254G>C	c.(253-255)AGG>ACG	p.R85T	ACP5_uc002msh.3_Missense_Mutation_p.R85T|ACP5_uc002msi.3_Missense_Mutation_p.R85T|ACP5_uc002msj.3_Missense_Mutation_p.R85T|ACP5_uc010dye.1_Missense_Mutation_p.R85T	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	85					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						GACCTGGAACCTCTTGTCATT	0.562													0	0	0	0.010729	0	10	39										G	11687879	C	G	11687879	3	3	46	1	0	0	0	0	1	0	0	0	164	681	24	4	739	4	ACP5	19	11687879	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	146053	11687879	47441104	1533	13230										
HOOK2	29911	broad.mit.edu	37	chr19	12885514	12885514	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttgggacctggatcttccGagatgccctggagccatgcc	13	12	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:12885514G>A	uc002muy.2	-	3	344	c.173C>T	c.(172-174)TCG>TTG	p.S58L	HOOK2_uc002muz.2_Missense_Mutation_p.S58L|HOOK2_uc002mva.2_Missense_Mutation_p.S58L	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	58	Sufficient for interaction with microtubules.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						TGGATCTTCCGAGATGCCCTG	0.587													0	0	0	0.00499	0	15	28										A	12885514	G	A	12885514	3	1	46	1	0	0	0	0	1	0	0	0	7283	1059	37	1	2070	1	HOOK2	19	12885514	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1197635	12885514	46243469	1534	13231										
MAST1	22983	broad.mit.edu	37	chr19	12958498	12958498	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtctacaaggagaggttcccGaaggtgaggtgggacccgag	17	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:12958498G>A	uc002mvm.2	+	6	689	c.561G>A	c.(559-561)CCG>CCA	p.P187P	MAST1_uc002mvk.2_Silent_p.P183P|MAST1_uc002mvl.2_3'UTR	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	187					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						AGAGGTTCCCGAAGGTGAGGT	0.672											OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	11	18										A	12958498	G	A	12958498	2	1	46	1	0	0	0	0	0	0	0	1	9324	1045	37	1		1	MAST1	19	12958498	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	72984	12958498	46170485	1535	13232										
NACC1	112939	broad.mit.edu	37	chr19	13246852	13246852	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagcgacagccctggctcCtaccacaatgaggaggacga	11	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13246852C>T	uc002mwm.2	+	2	999	c.831C>T	c.(829-831)TCC>TCT	p.S277S		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	277					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						GCCCTGGCTCCTACCACAATG	0.627													0	0	0	0.00499	0	14	12										T	13246852	C	T	13246852	2	4	46	1	0	0	0	0	0	0	0	1	10135	668	24	2		2	NACC1	19	13246852	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	288354	13246852	45882131	1536	13233										
IER2	9592	broad.mit.edu	37	chr19	13264058	13264058	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtcggtgtggaagatgtatCactcccgcatgcagcgcggt	14	10	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13264058C>T	uc002mwr.2	+	2	386	c.58C>T	c.(58-60)CAC>TAC	p.H20Y		NM_004907	NP_004898	Q9BTL4	IER2_HUMAN	immediate early response 2	20										kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			GAAGATGTATCACTCCCGCAT	0.667											OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	5										T	13264058	C	T	13264058	3	4	46	1	0	0	0	0	1	0	0	0	7505	826	29	1	60	1	IER2	19	13264058	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	17206	13264058	45864925	1537	13234										
CACNA1A	773	broad.mit.edu	37	chr19	13325339	13325339	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgaggtgtgaccagcaggtCtagcgtcttctgggacagat	15	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13325339C>G	uc010dze.2	-	39	6054	c.5818G>C	c.(5818-5820)GAC>CAC	p.D1940H	CACNA1A_uc010xnd.1_Missense_Mutation_p.D645H|CACNA1A_uc002mwx.3_Missense_Mutation_p.D645H|CACNA1A_uc010dzc.2_Missense_Mutation_p.D1465H|CACNA1A_uc002mwy.3_Missense_Mutation_p.D1939H|CACNA1A_uc002mwv.3_Missense_Mutation_p.D456H	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1940	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACCAGCAGGTCTAGCGTCTTC	0.597													0	0	0	0.004482	0	8	12										G	13325339	C	G	13325339	3	3	46	1	0	0	0	0	1	0	0	0	2538	913	32	1	1741	1	CACNA1A	19	13325339	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	61281	13325339	45803644	1538	13235										
CACNA1A	773	broad.mit.edu	37	chr19	13470507	13470507	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atgttgtcgaactgagtgatCccgttgttgggcccttccca	11	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13470507C>T	uc010dze.2	-	6	1127	c.891G>A	c.(889-891)GGG>GGA	p.G297G	CACNA1A_uc002mwy.3_Silent_p.G297G	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	297	I.|Extracellular (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACTGAGTGATCCCGTTGTTGG	0.547													0	0	0	0.004672	0	3	8										T	13470507	C	T	13470507	2	4	46	1	0	0	0	0	0	0	0	1	2538	842	30	1		1	CACNA1A	19	13470507	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	145168	13470507	45658476	1539	13236										
CC2D1A	54862	broad.mit.edu	37	chr19	14037992	14037992	+	Frame_Shift_Del	DEL	C	C	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acacacatgcacacagggggCtgttcaagactgaccgggtg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:14037992delC	uc002mxo.2	+	22	2529	c.2230delC	c.(2230-2232)CTGfs	p.L744fs	CC2D1A_uc002mxp.2_Frame_Shift_Del_p.L744fs|CC2D1A_uc010dzh.2_Frame_Shift_Del_p.L313fs|CC2D1A_uc002mxq.1_3'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	744	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			ACACAGGGGGCTGTTCAAGAC	0.602																		8	125	---	---								-	14037992	C	-	14037992	7	5	46	1	0	1	0	1	0	0	0	0	2726	796	28	0	2316	0	CC2D1A	19	14037992	Frame_Shift_Del	DEL	C	TCGA-DK-A1AC-01A-11D-A13W-08	567485	14037992	45090991	1540	13237										
CD97	976	broad.mit.edu	37	chr19	14507162	14507162	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctcttgcagatgtggacGaatgtcagcagaacccaagg	11	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:14507162G>A	uc002myl.2	+	5	478	c.355G>A	c.(355-357)GAA>AAA	p.E119K	CD97_uc002mym.2_Missense_Mutation_p.E119K|CD97_uc002myn.2_Intron	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	119	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						AGATGTGGACGAATGTCAGCA	0.562													0	0	0	0.00278	0	25	81										A	14507162	G	A	14507162	3	1	46	1	0	0	0	0	1	0	0	0	3049	1059	37	1	373	1	CD97	19	14507162	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	469170	14507162	44621821	1541	13238										
OR7A17	26333	broad.mit.edu	37	chr19	14991344	14991344	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggccacagtgtacatcactGaggctgttgcacttgtgtgt	12	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:14991344G>A	uc010xob.1	-	1	824	c.824C>T	c.(823-825)TCA>TTA	p.S275L		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GTACATCACTGAGGCTGTTGC	0.473													0	0	0	0.005443	0	27	74										A	14991344	G	A	14991344	3	1	46	1	0	0	0	0	1	0	0	0	11215	1294	45	1	107	1	OR7A17	19	14991344	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	484182	14991344	44137639	1542	13239										
CYP4F22	126410	broad.mit.edu	37	chr19	15648197	15648197	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcgcccccaaggatgacctCttctatggcttcctaaaacc	6	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:15648197C>T	uc002nbh.3	+	5	560	c.393C>T	c.(391-393)CTC>CTT	p.L131L		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	131						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						AGGATGACCTCTTCTATGGCT	0.453													0	0	0	0.00333	0	20	72										T	15648197	C	T	15648197	2	4	46	1	0	0	0	0	0	0	0	1	4189	900	32	1		1	CYP4F22	19	15648197	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	656853	15648197	43480786	1543	13240										
EPS15L1	58513	broad.mit.edu	37	chr19	16535906	16535906	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctccgtacctgtgtttgcttGaggctgtgcttgggggacag	15	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:16535906G>A	uc002ndz.1	-	9	786	c.780C>T	c.(778-780)CTC>CTT	p.L260L	EPS15L1_uc002ndx.2_Silent_p.L260L|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.L150L|EPS15L1_uc010xpf.1_Silent_p.L163L|EPS15L1_uc002nea.1_Silent_p.L260L|EPS15L1_uc010eah.1_Silent_p.L260L|EPS15L1_uc002neb.1_Silent_p.L106L|EPS15L1_uc002nec.1_Silent_p.L260L	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	260					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GTGTTTGCTTGAGGCTGTGCT	0.622													0	0	0	0.00499	0	16	60										A	16535906	G	A	16535906	2	1	46	1	0	0	0	0	0	0	0	1	5193	1277	45	1		1	EPS15L1	19	16535906	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	887709	16535906	42593077	1544	13241										
OCEL1	79629	broad.mit.edu	37	chr19	17339098	17339098	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgcagcccgggtttggaggGagtttgagatgaagcgaatg	17	5	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17339098G>T	uc002nfp.2	+	5	654	c.652G>T	c.(652-654)GAG>TAG	p.E218*		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	218										central_nervous_system(1)	1						GGTTTGGAGGGAGTTTGAGAT	0.493													1	0	7.11191e-15	0.013726	7.46269e-15	35	90										T	17339098	G	T	17339098	4	4	46	1	0	0	0	0	0	1	0	0	10816	1175	41	3	670	3	OCEL1	19	17339098	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	803192	17339098	41789885	1545	13242										
USHBP1	83878	broad.mit.edu	37	chr19	17375060	17375060	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagggtgacacttacgggtgGagcatgcctccctcgccggc	15	13	0	1	rs149022063	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17375060G>A	uc002nfs.1	-	2	162	c.49C>T	c.(49-51)CCA>TCA	p.P17S	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.L2L|USHBP1_uc010eam.1_5'UTR	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	17							PDZ domain binding			ovary(1)	1						CTTACGGGTGGAGCATGCCTC	0.652													0	0	0	0.000602	0	4	21										A	17375060	G	A	17375060	3	1	46	1	0	0	0	0	1	0	0	0	17034	1174	41	1	2110	1	USHBP1	19	17375060	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	35962	17375060	41753923	1546	13243										
PLVAP	83483	broad.mit.edu	37	chr19	17476312	17476312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccttctccaccttctgtttcGcctcctgactggcccgcagg	8	18	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17476312G>A	uc002ngk.1	-	3	1012	c.962C>T	c.(961-963)GCG>GTG	p.A321V		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTTCTGTTTCGCCTCCTGACT	0.667													0	0	0	0.004482	0	9	33										A	17476312	G	A	17476312	3	1	46	1	0	0	0	0	1	0	0	0	12116	1087	38	2	382	2	PLVAP	19	17476312	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	101252	17476312	41652671	1547	13244										
SLC27A1	376497	broad.mit.edu	37	chr19	17608118	17608118	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgaagcagccggtgcgcGaggcggagaggcgacaccgc	18	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17608118G>A	uc002ngu.1	+	7	1101	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	SLC27A1_uc002ngt.1_Missense_Mutation_p.E83K|SLC27A1_uc010xpp.1_Missense_Mutation_p.E172K|SLC27A1_uc002ngv.1_5'UTR	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	351	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						GCCGGTGCGCGAGGCGGAGAG	0.687													0	0	0	0.001984	0	3	10										A	17608118	G	A	17608118	3	1	46	1	0	0	0	0	1	0	0	0	14525	1059	37	1	1077	1	SLC27A1	19	17608118	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	131806	17608118	41520865	1548	13245										
JAK3	3718	broad.mit.edu	37	chr19	17942579	17942579	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagcagccgctgggcaggtaCtccatgaccagccgcaggct	13	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17942579C>T	uc002nhn.3	-	20	2809	c.2709G>A	c.(2707-2709)GAG>GAA	p.E903E	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Silent_p.E903E	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	903	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGGGCAGGTACTCCATGACCA	0.662		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.004482	0	7	16										T	17942579	C	T	17942579	2	4	46	1	0	0	0	0	0	0	0	1	7939	564	20	2		2	JAK3	19	17942579	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	334461	17942579	41186404	1549	13246										
NCAN	1463	broad.mit.edu	37	chr19	19359535	19359535	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggtccccctccggcagtgGagaatgcctcactcatcggt	12	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:19359535G>T	uc002nlz.2	+	14	3763	c.3664G>T	c.(3664-3666)GAG>TAG	p.E1222*	NCAN_uc002nma.2_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1222	Sushi.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TCCGGCAGTGGAGAATGCCTC	0.498													1	0	2.0095e-06	0.001984	2.05981e-06	7	24										T	19359535	G	T	19359535	4	4	46	1	0	0	0	0	0	1	0	0	10204	1175	41	3	3714	3	NCAN	19	19359535	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1416956	19359535	39769448	1550	13247										
SF4	57794	broad.mit.edu	37	chr19	19420949	19420949	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacttcagaaactgctgcaaGaagctaccatcgttggcaaa	8	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:19420949G>A	uc002nmh.2	-	3	269	c.267C>T	c.(265-267)TTC>TTT	p.F89F	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_Intron|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	89					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						ACTGCTGCAAGAAGCTACCAT	0.517													0	0	0	0.004007	0	15	65										A	19420949	G	A	19420949	2	1	46	1	0	0	0	0	0	0	0	1	14155	933	33	1		1	SF4	19	19420949	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	61414	19420949	39708034	1551	13248										
PBX4	80714	broad.mit.edu	37	chr19	19675894	19675894	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttgttgccaaaccagttaGagacctgcggacacacagga	10	10	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:19675894G>A	uc002nmy.2	-	6	774	c.773C>T	c.(772-774)TCT>TTT	p.S258F	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_Missense_Mutation_p.S93F	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	258	Homeobox; TALE-type.						sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						AAACCAGTTAGAGACCTGCGG	0.532													0	0	0	0.01441	0	123	129										A	19675894	G	A	19675894	3	1	46	1	0	0	0	0	1	0	0	0	11495	942	33	1	363	1	PBX4	19	19675894	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	254945	19675894	39453089	1552	13249										
ZNF493	284443	broad.mit.edu	37	chr19	21607496	21607496	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttactaaacataagataattCatactgaagagaaaccctac	4	8	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:21607496C>G	uc002npx.2	+	2	1931	c.1651C>G	c.(1651-1653)CAT>GAT	p.H551D	ZNF493_uc002npw.2_Missense_Mutation_p.H679D|ZNF493_uc002npy.2_Missense_Mutation_p.H551D	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	551	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAAGATAATTCATACTGAAGA	0.348													0	0	0	0.001984	0	7	36										G	21607496	C	G	21607496	3	3	46	1	0	0	0	0	1	0	0	0	17941	826	29	1	2112	1	ZNF493	19	21607496	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1931602	21607496	37521487	1553	13250										
ZNF429	353088	broad.mit.edu	37	chr19	21719352	21719352	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcagatagatacaagacaaGacatactggaaagaaacctt	8	7	0	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:21719352G>C	uc002nqd.1	+	4	634	c.497G>C	c.(496-498)AGA>ACA	p.R166T	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	166	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TACAAGACAAGACATACTGGA	0.313													0	0	0	0.001984	0	7	54										C	21719352	G	C	21719352	3	2	46	1	0	0	0	0	1	0	0	0	17899	942	33	1	511	1	ZNF429	19	21719352	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	111856	21719352	37409631	1554	13251										
ZNF676	163223	broad.mit.edu	37	chr19	22364107	22364107	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttacatttcaaacctttctCtccagtatgccttatcttat	2	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:22364107C>T	uc002nqs.1	-	3	730	c.412G>A	c.(412-414)GAG>AAG	p.E138K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAACCTTTCTCTCCAGTATGC	0.318													0	0	0	0.014323	0	21	105										T	22364107	C	T	22364107	3	4	46	1	0	0	0	0	1	0	0	0	18080	922	32	1	1358	1	ZNF676	19	22364107	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	644755	22364107	36764876	1555	13252										
ZNF254	9534	broad.mit.edu	37	chr19	24309428	24309428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	catttatcatagagagaagtCctacaaatgtaaagaatgtg	8	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:24309428C>T	uc002nru.2	+	4	760	c.626C>T	c.(625-627)TCC>TTC	p.S209F	ZNF254_uc010xrk.1_Missense_Mutation_p.S124F	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	209					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AGAGAGAAGTCCTACAAATGT	0.303													0	0	0	0.012319	0	21	66										T	24309428	C	T	24309428	3	4	46	1	0	0	0	0	1	0	0	0	17795	855	30	1	640	1	ZNF254	19	24309428	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1945321	24309428	34819555	1556	13253										
ZNF507	22847	broad.mit.edu	37	chr19	32845546	32845546	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggacagaccaaaacgcttcaGacgatgacattttgaaagag	10	8	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:32845546G>A	uc002nte.2	+	3	2082	c.1810G>A	c.(1810-1812)GAC>AAC	p.D604N	ZNF507_uc002ntc.2_Missense_Mutation_p.D604N|ZNF507_uc010xrn.1_Missense_Mutation_p.D604N|ZNF507_uc002ntd.2_Missense_Mutation_p.D604N	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	604					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					AAACGCTTCAGACGATGACAT	0.468													0	0	0	0.001984	0	6	41										A	32845546	G	A	32845546	3	1	46	1	0	0	0	0	1	0	0	0	17950	942	33	1	1812	1	ZNF507	19	32845546	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	8536118	32845546	26283437	1557	13254										
C19orf40	91442	broad.mit.edu	37	chr19	33467474	33467474	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttaaagctccccttctcctCcagaagtttccaagcatcca	5	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:33467474C>T	uc002nud.3	+	5	652	c.534C>T	c.(532-534)CTC>CTT	p.L178L		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	178	RuvA domain 2-like.				DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					CCCTTCTCCTCCAGAAGTTTC	0.542								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00632	0	29	114										T	33467474	C	T	33467474	2	4	46	1	0	0	0	0	0	0	0	1	1923	842	30	1		1	C19orf40	19	33467474	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	621928	33467474	25661509	1558	13255										
GPATCH1	55094	broad.mit.edu	37	chr19	33579137	33579137	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggggcctttagtggaggtttCtctgctggatacttcaatac	12	8	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:33579137C>T	uc002nug.1	+	2	485	c.171C>T	c.(169-171)TTC>TTT	p.F57F		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	57						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					GTGGAGGTTTCTCTGCTGGAT	0.383													0	0	0	0.007291	0	26	59										T	33579137	C	T	33579137	2	4	46	1	0	0	0	0	0	0	0	1	6590	912	32	1		1	GPATCH1	19	33579137	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	111663	33579137	25549846	1559	13256										
ZNF302	55900	broad.mit.edu	37	chr19	35175770	35175770	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatcacttactaaccatcaGagcactcacacgggagagaa	7	12	4	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:35175770G>A	uc002nvr.1	+	6	1223	c.960G>A	c.(958-960)CAG>CAA	p.Q320Q	ZNF302_uc002nvp.1_Silent_p.Q276Q|ZNF302_uc002nvq.1_Silent_p.Q276Q|ZNF302_uc002nvs.1_Silent_p.Q276Q	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	355	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CTAACCATCAGAGCACTCACA	0.438													0	0	0	0.008871	0	18	68										A	35175770	G	A	35175770	2	1	46	1	0	0	0	0	0	0	0	1	17829	933	33	1		1	ZNF302	19	35175770	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1596633	35175770	23953213	1560	13257										
ZNF792	126375	broad.mit.edu	37	chr19	35451187	35451187	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggccatggctgatgtcatatCcacactgtcaggcacccagg	11	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:35451187C>T	uc002nxh.1	-	3	622	c.235G>A	c.(235-237)GAT>AAT	p.D79N		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GATGTCATATCCACACTGTCA	0.537													0	0	0	0.008291	0	7	35										T	35451187	C	T	35451187	3	4	46	1	0	0	0	0	1	0	0	0	18161	855	30	1	1671	1	ZNF792	19	35451187	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	275417	35451187	23677796	1561	13258										
GRAMD1A	57655	broad.mit.edu	37	chr19	35512680	35512680	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctatccggcctgcggcggcgGaagcggcccctgagctggcg	17	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:35512680G>A	uc010xse.1	+	15	1802	c.1665G>A	c.(1663-1665)CGG>CGA	p.R555R	GRAMD1A_uc002nxk.2_Silent_p.R548R|GRAMD1A_uc002nxl.2_Silent_p.R321R|GRAMD1A_uc010xsf.1_Silent_p.R560R|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Silent_p.R170R	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	555						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCGGCGGCGGAAGCGGCCCC	0.682													0	0	0	0.004482	0	7	17										A	35512680	G	A	35512680	2	1	46	1	0	0	0	0	0	0	0	1	6747	1161	41	1		1	GRAMD1A	19	35512680	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	61493	35512680	23616303	1562	13259										
ARHGAP33	115703	broad.mit.edu	37	chr19	36278895	36278895	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagctacccgccagccccctCctgctttccccctgaccacc	5	24	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:36278895C>T	uc002obs.1	+	21	3030	c.2945C>T	c.(2944-2946)TCC>TTC	p.S982F	ARHGAP33_uc002obt.1_Missense_Mutation_p.S979F|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.S731F	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1143					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCAGCCCCCTCCTGCTTTCCC	0.667													0	0	0	0.004672	0	3	8										T	36278895	C	T	36278895	3	4	46	1	0	0	0	0	1	0	0	0	882	855	30	1	3510	1	ARHGAP33	19	36278895	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	766215	36278895	22850088	1563	13260										
WDR62	284403	broad.mit.edu	37	chr19	36590419	36590419	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagaccatcctggatgcccAggacctggattgctacttta	9	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:36590419A>G	uc002odc.2	+	22	2730	c.2639A>G	c.(2638-2640)CAG>CGG	p.Q880R	WDR62_uc002odd.2_Missense_Mutation_p.Q880R	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	880					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTGGATGCCCAGGACCTGGAT	0.632													0	0	0	0.010818	0	33	47										G	36590419	A	G	36590419	3	3	46	1	0	0	0	0	1	0	0	0	17310	188	7	5	2725	5	WDR62	19	36590419	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	311524	36590419	22538564	1564	13261										
ZNF565	147929	broad.mit.edu	37	chr19	36673778	36673778	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcccacattccttacactCatagggtttctccccagaat	4	15	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:36673778C>T	uc002odn.2	-	5	1198	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	ZNF565_uc010ees.2_Missense_Mutation_p.E299K|ZNF565_uc002odo.2_Missense_Mutation_p.E364K	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	364	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TCCTTACACTCATAGGGTTTC	0.488													0	0	0	0.012213	0	30	71										T	36673778	C	T	36673778	3	4	46	1	0	0	0	0	1	0	0	0	17993	835	29	1	413	1	ZNF565	19	36673778	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	83359	36673778	22455205	1565	13262										
SIPA1L3	23094	broad.mit.edu	37	chr19	38597188	38597188	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgtttcagccgactccacgGgaacccactccctctacacg	7	18	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:38597188G>A	uc002ohk.2	+	7	2550	c.2041G>A	c.(2041-2043)GGA>AGA	p.G681R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	681	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CGACTCCACGGGAACCCACTC	0.413													0	0	0	0.010729	0	8	103										A	38597188	G	A	38597188	3	1	46	1	0	0	0	0	1	0	0	0	14331	1233	43	2	2059	2	SIPA1L3	19	38597188	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1923410	38597188	20531795	1566	13263										
IL28B	282617	broad.mit.edu	37	chr19	39734518	39734518	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggtggaggcggccccgggtCctgggccctgccgtgggctg	20	13	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39734518C>G	uc010xut.1	-	4	442	c.438G>C	c.(436-438)AGG>AGC	p.R146S	IL28B_uc010xuu.1_Missense_Mutation_p.R146S	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	146					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCCCCGGGTCCTGGGCCCTG	0.687													0	0	0	0.013537	0	6	8										G	39734518	C	G	39734518	3	3	46	1	0	0	0	0	1	0	0	0	7683	854	30	1	159	1	IL28B	19	39734518	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1137330	39734518	19394465	1567	13264										
IL28B	282617	broad.mit.edu	37	chr19	39734756	39734756	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctccagaaccttcagcgtCagggccagctcagcctccaa	9	17	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39734756C>T	uc010xut.1	-	3	304	c.300G>A	c.(298-300)CTG>CTA	p.L100L	IL28B_uc010xuu.1_Silent_p.L100L	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	100					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCTTCAGCGTCAGGGCCAGCT	0.473													0	0	0	0.007413	0	18	21										T	39734756	C	T	39734756	2	4	46	1	0	0	0	0	0	0	0	1	7683	813	29	1		1	IL28B	19	39734756	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	238	39734756	19394227	1568	13265										
SAMD4B	55095	broad.mit.edu	37	chr19	39868130	39868130	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgtcctcccatccaggatgtGctggaaggcgggaacctacg	13	12	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39868130G>A	uc002olb.2	+	10	2145	c.1110G>A	c.(1108-1110)GTG>GTA	p.V370V	SAMD4B_uc002ola.2_Silent_p.V370V	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	370	SAM.						protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCCAGGATGTGCTGGAAGGCG	0.582													0	0	0	0.006122	0	17	58										A	39868130	G	A	39868130	2	1	46	1	0	0	0	0	0	0	0	1	13822	1306	46	2		2	SAMD4B	19	39868130	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	133374	39868130	19260853	1569	13266										
RPS16	6217	broad.mit.edu	37	chr19	39926340	39926340	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgcagtgcgccacagctgtCgctgtcttctgtaagataca	10	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39926340C>T	uc002olk.2	-	2	140	c.57G>A	c.(55-57)GCG>GCA	p.A19A	RPS16_uc002oll.2_Silent_p.A19A|RPS16_uc002olm.2_Silent_p.A19A	NM_001020	NP_001011	P62249	RS16_HUMAN	ribosomal protein S16	19					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			skin(1)	1	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCACAGCTGTCGCTGTCTTCT	0.602													0	0	0	0.000602	0	4	31										T	39926340	C	T	39926340	2	4	46	1	0	0	0	0	0	0	0	1	13627	871	31	1		1	RPS16	19	39926340	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	58210	39926340	19202643	1570	13267										
SUPT5H	6829	broad.mit.edu	37	chr19	39965239	39965239	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctacaacccacacacgccaGgctcaggcatcgagcagaac	9	16	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39965239G>T	uc002olo.3	+	28	3084	c.2905G>T	c.(2905-2907)GGC>TGC	p.G969C	SUPT5H_uc002olp.3_Missense_Mutation_p.G969C|SUPT5H_uc002olq.3_Missense_Mutation_p.G965C|SUPT5H_uc002oln.3_Missense_Mutation_p.G969C|SUPT5H_uc002olr.3_Missense_Mutation_p.G969C|SUPT5H_uc002ols.1_Missense_Mutation_p.G592C	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	969					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ACACACGCCAGGCTCAGGCAT	0.617											OREG0025462	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.51602e-12	0.008871	3.67699e-12	19	31										T	39965239	G	T	39965239	3	4	46	1	0	0	0	0	1	0	0	0	15396	1000	35	4	3011	4	SUPT5H	19	39965239	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	38899	39965239	19163744	1571	13268										
LGALS13	29124	broad.mit.edu	37	chr19	40097960	40097960	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagagatatctccctgacctCagtgtgtgtctgcaattgag	11	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40097960C>T	uc002omb.2	+	4	441	c.401C>T	c.(400-402)TCA>TTA	p.S134L		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	134	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TCCCTGACCTCAGTGTGTGTC	0.463													0	0	0	0.009718	0	42	53										T	40097960	C	T	40097960	3	4	46	1	0	0	0	0	1	0	0	0	8740	838	29	1	415	1	LGALS13	19	40097960	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	132721	40097960	19031023	1572	13269										
FCGBP	8857	broad.mit.edu	37	chr19	40433739	40433739	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttgccattgaatgtcactGaccccttcagcgtgacactg	8	13	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40433739G>A	uc002omp.3	-	2	538	c.530C>T	c.(529-531)TCA>TTA	p.S177L		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	177	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAATGTCACTGACCCCTTCAG	0.577													0	0	0	0.01441	0	52	60										A	40433739	G	A	40433739	3	1	46	1	0	0	0	0	1	0	0	0	5778	1294	45	1	15827	1	FCGBP	19	40433739	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	335779	40433739	18695244	1573	13270										
ZNF780B	163131	broad.mit.edu	37	chr19	40542198	40542198	+	Missense_Mutation	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttgcatttatagggtttctCtccagtatgaatactctgat							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40542198C>T	uc002omu.2	-	5	633	c.568G>A	c.(568-570)GAG>AAG	p.E190K	ZNF780B_uc002omv.2_Missense_Mutation_p.E42K	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAGGGTTTCTCTCCAGTATGA	0.338													0	0	0	0.001855	0	13	102										T	40542198	C	T	40542198	3	4	46	1	0	0	0	0	1	0	0	0	18150	922	32	1	1937	1	ZNF780B	19	40542198	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	108459	40542198	18586785	1574	13271	64	2								
ZNF780B	163131	broad.mit.edu	37	chr19	40542207	40542207	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atagggtttctctccagtatGaatactctgatgctgaataa							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40542207G>A	uc002omu.2	-	5	624	c.559C>T	c.(559-561)CAT>TAT	p.H187Y	ZNF780B_uc002omv.2_Missense_Mutation_p.H39Y	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	187	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCTCCAGTATGAATACTCTGA	0.348													0	0	0	0.00245	0	14	102										A	40542207	G	A	40542207	3	1	46	1	0	0	0	0	1	0	0	0	18150	1290	45	1	1946	1	ZNF780B	19	40542207	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	9	40542207	18586776	1575	13272	64	2								
MAP3K10	4294	broad.mit.edu	37	chr19	40715101	40715101	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccctgcaagccccagcatCatcccccggctgagggccat	9	20	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40715101C>T	uc002ona.2	+	6	1815	c.1527C>T	c.(1525-1527)ATC>ATT	p.I509I	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	509					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GCCCCAGCATCATCCCCCGGC	0.468													0	0	0	0.005524	0	35	52										T	40715101	C	T	40715101	2	4	46	1	0	0	0	0	0	0	0	1	9244	816	29	1		1	MAP3K10	19	40715101	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	172894	40715101	18413882	1576	13273										
SERTAD3	29946	broad.mit.edu	37	chr19	40947819	40947819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttggagggtgttatggatgaGgacatgcctgcggaggctgg	19	5	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40947819G>A	uc002onu.3	-	2	447	c.169C>T	c.(169-171)CTC>TTC	p.L57F	SERTAD3_uc002onv.3_Missense_Mutation_p.L57F	NM_013368	NP_037500	Q9UJW9	SRTD3_HUMAN	RPA-binding trans-activator	57	SERTA.				negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTATGGATGAGGACATGCCTG	0.662													0	0	0	0.001168	0	5	11										A	40947819	G	A	40947819	3	1	46	1	0	0	0	0	1	0	0	0	14122	1000	35	2	425	2	SERTAD3	19	40947819	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	232718	40947819	18181164	1577	13274										
SPTBN4	57731	broad.mit.edu	37	chr19	41008759	41008759	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgattcggcaggagaagctGgaactactggcacagaggtt	14	8	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41008759G>A	uc002ony.2	+	11	1367	c.1281G>A	c.(1279-1281)CTG>CTA	p.L427L	SPTBN4_uc002onx.2_Silent_p.L427L|SPTBN4_uc002onz.2_Silent_p.L427L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	427					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGAGAAGCTGGAACTACTGG	0.597													0	0	0	0.01441	0	50	70										A	41008759	G	A	41008759	2	1	46	1	0	0	0	0	0	0	0	1	15120	1335	47	2		2	SPTBN4	19	41008759	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	60940	41008759	18120224	1578	13275										
SHKBP1	92799	broad.mit.edu	37	chr19	41088265	41088265	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcccactgcaggggtctttCatctgggggtgcctgtggag	16	10	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41088265C>T	uc002oob.2	+	10	902	c.853C>T	c.(853-855)CAT>TAT	p.H285Y	SHKBP1_uc002ooc.2_Intron|SHKBP1_uc002ood.2_Missense_Mutation_p.H285Y|SHKBP1_uc010xvl.1_Missense_Mutation_p.H208Y|SHKBP1_uc002ooe.2_Missense_Mutation_p.H122Y|SHKBP1_uc002oof.2_Missense_Mutation_p.H122Y|SHKBP1_uc010xvm.1_Missense_Mutation_p.H122Y|SHKBP1_uc010xvn.1_Missense_Mutation_p.H163Y	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	285	WD 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGGGTCTTTCATCTGGGGGT	0.597													0	0	0	0.014323	0	23	92										T	41088265	C	T	41088265	3	4	46	1	0	0	0	0	1	0	0	0	14284	826	29	1	891	1	SHKBP1	19	41088265	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	79506	41088265	18040718	1579	13276										
LTBP4	8425	broad.mit.edu	37	chr19	41117097	41117097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcccaggcctgtgtggccGaggggcctgcaagaacctgc	16	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41117097G>A	uc002ooh.1	+	16	2051	c.2051G>A	c.(2050-2052)CGA>CAA	p.R684Q	LTBP4_uc002oog.1_Missense_Mutation_p.R647Q|LTBP4_uc002ooi.1_Missense_Mutation_p.R617Q|LTBP4_uc002ooj.1_Intron|LTBP4_uc010xvo.1_Intron|LTBP4_uc010ehb.1_5'Flank|LTBP4_uc002ook.1_5'Flank|LTBP4_uc002ool.1_5'Flank|LTBP4_uc002oom.1_5'Flank|LTBP4_uc010xvp.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	684	Cys-rich.|EGF-like 6; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGTGTGGCCGAGGGGCCTGC	0.647													0	0	0	0.001168	0	6	35										A	41117097	G	A	41117097	3	1	46	1	0	0	0	0	1	0	0	0	9076	1058	37	1	2406	1	LTBP4	19	41117097	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	28832	41117097	18011886	1580	13277										
LTBP4	8425	broad.mit.edu	37	chr19	41118028	41118028	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgccctgggcaggagtgtgtGaactcgcccggctccttcca	13	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41118028G>A	uc002ooh.1	+	18	2430	c.2430G>A	c.(2428-2430)GTG>GTA	p.V810V	LTBP4_uc002oog.1_Silent_p.V773V|LTBP4_uc002ooi.1_Silent_p.V743V|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc010xvo.1_Silent_p.V98V|LTBP4_uc010ehb.1_Silent_p.V30V|LTBP4_uc002ook.1_Silent_p.V30V|LTBP4_uc002ool.1_5'Flank|LTBP4_uc002oom.1_5'Flank|LTBP4_uc010xvp.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	810	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGAGTGTGTGAACTCGCCCG	0.637													0	0	0	0.001168	0	4	15										A	41118028	G	A	41118028	2	1	46	1	0	0	0	0	0	0	0	1	9076	1277	45	1		1	LTBP4	19	41118028	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	931	41118028	18010955	1581	13278										
CYP2A6	1548	broad.mit.edu	37	chr19	41349839	41349839	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acggtggtgaagaagagaaaGagctccattctggccaggcc	14	9	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41349839G>A	uc002opl.3	-	9	1368	c.1347C>T	c.(1345-1347)CTC>CTT	p.L449L		NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	449					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	AGAAGAGAAAGAGCTCCATTC	0.587													0	0	0	0.003163	0	9	55										A	41349839	G	A	41349839	2	1	46	1	0	0	0	0	0	0	0	1	4162	929	33	1		1	CYP2A6	19	41349839	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	231811	41349839	17779144	1582	13279										
GRIK5	2901	broad.mit.edu	37	chr19	42557979	42557979	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caccctgggtctgctcacctCacggtggccctgccgggact	12	17	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42557979C>T	uc002osj.1	-	9	1194	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	GRIK5_uc010eib.1_Missense_Mutation_p.E306K	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	387	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTGCTCACCTCACGGTGGCCC	0.647													0	0	0	0.001168	0	4	28										T	42557979	C	T	42557979	3	4	46	1	0	0	0	0	1	0	0	0	6777	835	29	1	1827	1	GRIK5	19	42557979	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1208140	42557979	16571004	1583	13280										
ZNF574	64763	broad.mit.edu	37	chr19	42584118	42584118	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccctgagccccctgtgtctGaggagacctcagcagggccc	12	17	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42584118G>C	uc002osm.3	+	2	1529	c.1360G>C	c.(1360-1362)GAG>CAG	p.E454Q	ZNF574_uc002osk.3_Missense_Mutation_p.E544Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CCCTGTGTCTGAGGAGACCTC	0.637													0	0	0	0.004289	0	38	40										C	42584118	G	C	42584118	3	2	46	1	0	0	0	0	1	0	0	0	18003	1291	45	1	1362	1	ZNF574	19	42584118	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	26139	42584118	16544865	1584	13281										
TMEM145	284339	broad.mit.edu	37	chr19	42827892	42827892	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtgacgtttatcagcgactCggtgcccaacttcacggagc	11	13	2	1	rs149140216		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42827892C>G	uc002otk.1	+	14	1404	c.1352C>G	c.(1351-1353)TCG>TGG	p.S451W	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	451						integral to membrane					0		Prostate(69;0.00682)				ATCAGCGACTCGGTGCCCAAC	0.682													0	0	0	0.010729	0	11	46										G	42827892	C	G	42827892	3	3	46	1	0	0	0	0	1	0	0	0	16056	893	31	1	1406	1	TMEM145	19	42827892	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	243774	42827892	16301091	1585	13282										
MEGF8	1954	broad.mit.edu	37	chr19	42854308	42854308	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccttccccaggagatctcCttcttcttcctggagcccta	6	18	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42854308C>T	uc002otl.3	+	14	2942	c.2307C>T	c.(2305-2307)TCC>TCT	p.S769S	MEGF8_uc002otm.3_Silent_p.S377S	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	836	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				AGGAGATCTCCTTCTTCTTCC	0.607													0	0	0	0.003163	0	15	86										T	42854308	C	T	42854308	2	4	46	1	0	0	0	0	0	0	0	1	9463	668	24	2		2	MEGF8	19	42854308	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	26416	42854308	16274675	1586	13283										
LIPE	3991	broad.mit.edu	37	chr19	42930623	42930623	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcagaatctgtgacccactCagaaagtgccttccactcta	6	14	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42930623C>G	uc002otr.2	-	1	956	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	227					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GTGACCCACTCAGAAAGTGCC	0.493													0	0	0	0.01441	0	46	131										G	42930623	C	G	42930623	3	3	46	1	0	0	0	0	1	0	0	0	8821	835	29	1	2591	1	LIPE	19	42930623	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	76315	42930623	16198360	1587	13284										
PSG7	5676	broad.mit.edu	37	chr19	43428961	43428961	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttggaggaactagtagaattCagggtaatgtccagtctaca	11	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:43428961C>T	uc002ovl.3	-	7	1361	c.1259G>A	c.(1258-1260)TGA>TAA	p.*420*	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Silent_p.*298*	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	420					female pregnancy	extracellular region					0		Prostate(69;0.00682)				tagtagaattcagggtaatgt	0													0	0	0	0.008871	0	20	83										T	43428961	C	T	43428961	2	4	46	1	0	0	0	0	0	0	0	1	12660	837	29	1		1	PSG7	19	43428961	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	498338	43428961	15700022	1588	13285										
CD177	57126	broad.mit.edu	37	chr19	43866321	43866321	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaaccacaccagacaaatcgGgatcttctctgcgcgtgaga	10	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:43866321G>T	uc002owi.2	+	10	1205	c.1163G>T	c.(1162-1164)GGG>GTG	p.G388V	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	388					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				AGACAAATCGGGATCTTCTCT	0.592													1	0	1.76689e-08	0.006214	1.82753e-08	8	79										T	43866321	G	T	43866321	3	4	46	1	0	0	0	0	1	0	0	0	2971	1232	43	4	1197	4	CD177	19	43866321	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	437360	43866321	15262662	1589	13286										
LYPD5	284348	broad.mit.edu	37	chr19	44302740	44302740	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cactcggcgccgctgagcgtCggcgggtcgggtgctggcaa	18	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44302740C>T	uc002oxm.3	-	4	465	c.384G>A	c.(382-384)CCG>CCA	p.P128P	LYPD5_uc002oxn.3_Silent_p.P85P	NM_001031749	NP_001026919	Q6UWN5	LYPD5_HUMAN	LY6/PLAUR domain containing 5 isoform A	128						anchored to membrane|plasma membrane					0		Prostate(69;0.0352)				CGCTGAGCGTCGGCGGGTCGG	0.677													0	0	0	0.008291	0	11	50										T	44302740	C	T	44302740	2	4	46	1	0	0	0	0	0	0	0	1	9113	871	31	1		1	LYPD5	19	44302740	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	436419	44302740	14826243	1590	13287										
ZNF283	284349	broad.mit.edu	37	chr19	44351438	44351438	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgttcaacatgagagaactCatacagctgaaaaacacttt	6	8	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44351438C>T	uc002oxr.3	+	7	953	c.685C>T	c.(685-687)CAT>TAT	p.H229Y	ZNF283_uc002oxp.3_Missense_Mutation_p.H90Y	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGAGAGAACTCATACAGCTGA	0.368													0	0	0	0.005524	0	37	64										T	44351438	C	T	44351438	3	4	46	1	0	0	0	0	1	0	0	0	17817	826	29	1	699	1	ZNF283	19	44351438	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	48698	44351438	14777545	1591	13288										
ZNF230	7773	broad.mit.edu	37	chr19	44514653	44514653	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccttcagtgatgttgccatCtttgatcctcctcagcagtt	7	12	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44514653C>G	uc002oyb.1	+	5	713	c.462C>G	c.(460-462)ATC>ATG	p.I154M		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	154	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				ATGTTGCCATCTTTGATCCTC	0.448													0	0	0	0.010818	0	33	146										G	44514653	C	G	44514653	3	3	46	1	0	0	0	0	1	0	0	0	17781	903	32	1	476	1	ZNF230	19	44514653	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	163215	44514653	14614330	1592	13289										
ZNF284	342909	broad.mit.edu	37	chr19	44585289	44585289	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaacttcagaaacctgctatCagtgggtgagcacaggcacc	11	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44585289C>T	uc002oyg.1	+	3	353	c.137C>T	c.(136-138)TCA>TTA	p.S46L	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AACCTGCTATCAGTGGGTGAG	0.468													0	0	0	0.013114	0	48	83										T	44585289	C	T	44585289	3	4	46	1	0	0	0	0	1	0	0	0	17818	838	29	1	143	1	ZNF284	19	44585289	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	70636	44585289	14543694	1593	13290										
ZNF226	7769	broad.mit.edu	37	chr19	44676255	44676255	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtaggaagcagtgaccttCaaggacgtggctgtggcctt	14	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44676255C>T	uc002oyp.2	+	4	174	c.30C>T	c.(28-30)TTC>TTT	p.F10F	ZNF226_uc002oyn.2_Silent_p.F10F|ZNF226_uc002oyo.2_Silent_p.F10F|ZNF226_uc002oyq.2_5'UTR|ZNF226_uc002oyr.2_5'UTR|ZNF226_uc010ejg.2_Silent_p.F10F|ZNF226_uc002oys.2_Silent_p.F10F|ZNF226_uc002oyt.2_Silent_p.F10F	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CAGTGACCTTCAAGGACGTGG	0.507													0	0	0	0.01441	0	52	89										T	44676255	C	T	44676255	2	4	46	1	0	0	0	0	0	0	0	1	17777	825	29	1		1	ZNF226	19	44676255	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	90966	44676255	14452728	1594	13291										
PVRL2	5819	broad.mit.edu	37	chr19	45391385	45391385	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggaaatgcctcgataccatGagctgcccaccttggaagaa	10	11	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:45391385G>C	uc002ozw.1	+	9	1756	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q		NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	456	Cytoplasmic (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TCGATACCATGAGCTGCCCAC	0.572													0	0	0	0.007413	0	18	77										C	45391385	G	C	45391385	3	2	46	1	0	0	0	0	1	0	0	0	12840	1291	45	1	1802	1	PVRL2	19	45391385	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	715130	45391385	13737598	1595	13292										
ERCC2	2068	broad.mit.edu	37	chr19	45873455	45873455	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcggggtagatgtagtcgTacgggaagtagaccaggagc	17	7	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:45873455T>C	uc002pbj.2	-	2	88	c.41A>G	c.(40-42)TAC>TGC	p.Y14C	ERCC2_uc010ejz.2_Missense_Mutation_p.Y14C|ERCC2_uc002pbk.2_5'UTR|ERCC2_uc002pbl.3_5'UTR|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	14	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GATGTAGTCGTACGGGAAGTA	0.682			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001855	0	12	27										C	45873455	T	C	45873455	3	2	46	1	0	0	0	0	1	0	0	0	5213	1638	57	5	2386	5	ERCC2	19	45873455	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	482070	45873455	13255528	1596	13293										
SIX5	147912	broad.mit.edu	37	chr19	46271356	46271356	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgcgctgtcgccggttcttGaaccagttgctgacctgcgt	12	13	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:46271356G>A	uc002pdb.2	-	1	1142	c.747C>T	c.(745-747)TTC>TTT	p.F249F	SIX5_uc002pdc.2_Silent_p.F249F	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	249	Homeobox.					cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		GCCGGTTCTTGAACCAGTTGC	0.716													0	0	0	0.000602	0	5	15										A	46271356	G	A	46271356	2	1	46	1	0	0	0	0	0	0	0	1	14350	1281	45	1		1	SIX5	19	46271356	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	397901	46271356	12857627	1597	13294										
PNMAL2	57469	broad.mit.edu	37	chr19	46997390	46997390	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagctccagaagacccccttCgtcctcacggtgctcgctcc	8	19	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:46997390C>T	uc002pes.2	-	1	1780	c.1333G>A	c.(1333-1335)GAA>AAA	p.E445K	uc002peu.1_5'Flank	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	445										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		AGACCCCCTTCGTCCTCACGG	0.642													0	0	0	0.009535	0	27	50										T	46997390	C	T	46997390	3	4	46	1	0	0	0	0	1	0	0	0	12158	893	31	1	578	1	PNMAL2	19	46997390	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	726034	46997390	12131593	1598	13295										
HSD17B14	51171	broad.mit.edu	37	chr19	49334955	49334955	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgtacgtccccagtaggttCagctccagcagctggcggaa	13	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:49334955C>T	uc002pkv.1	-	5	605	c.339G>A	c.(337-339)CTG>CTA	p.L113L	HSD17B14_uc010emk.1_Silent_p.L113L	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	113					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		CCAGTAGGTTCAGCTCCAGCA	0.607													0	0	0	0.00278	0	20	98										T	49334955	C	T	49334955	2	4	46	1	0	0	0	0	0	0	0	1	7383	813	29	1		1	HSD17B14	19	49334955	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2337565	49334955	9794028	1599	13296										
FTL	2512	broad.mit.edu	37	chr19	49469600	49469600	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaagctgccatggccctggaGaaaaagctgaaccaggccct	11	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:49469600G>T	uc002plo.2	+	3	511	c.312G>T	c.(310-312)GAG>GAT	p.E104D	FTL_uc002pln.1_3'UTR	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	104	Ferritin-like diiron.				cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	TGGCCCTGGAGAAAAAGCTGA	0.537													1	0	9.86323e-18	0.003954	1.04101e-17	26	31										T	49469600	G	T	49469600	3	4	46	1	0	0	0	0	1	0	0	0	6084	933	33	3	322	3	FTL	19	49469600	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	134645	49469600	9659383	1600	13297										
TEAD2	8463	broad.mit.edu	37	chr19	49846565	49846565	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtcatgtgttccaggctctCatactggctgctcactccgt	10	13	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:49846565C>T	uc002pnj.2	-	10	1091	c.1000G>A	c.(1000-1002)GAG>AAG	p.E334K	TEAD2_uc002png.2_Missense_Mutation_p.E337K|TEAD2_uc002pnh.2_Missense_Mutation_p.E338K|TEAD2_uc002pni.2_Missense_Mutation_p.E337K|TEAD2_uc010yao.1_Missense_Mutation_p.E206K|TEAD2_uc010emw.2_Missense_Mutation_p.E337K	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	334	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		TCCAGGCTCTCATACTGGCTG	0.617													0	0	0	0.00278	0	19	51										T	49846565	C	T	49846565	3	4	46	1	0	0	0	0	1	0	0	0	15736	835	29	1	355	1	TEAD2	19	49846565	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	376965	49846565	9282418	1601	13298										
TSKS	60385	broad.mit.edu	37	chr19	50243401	50243401	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagggtggagctcagggcctCtgccctgacgtgtttggcta	15	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50243401C>T	uc002ppm.2	-	10	1548	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	513							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CTCAGGGCCTCTGCCCTGACG	0.647													0	0	0	0.008871	0	17	72										T	50243401	C	T	50243401	3	4	46	1	0	0	0	0	1	0	0	0	16623	922	32	1	249	1	TSKS	19	50243401	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	396836	50243401	8885582	1602	13299										
TSKS	60385	broad.mit.edu	37	chr19	50245148	50245148	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atattccctggtaccagaatCttcttgtgtagcctctgaca	7	11	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50245148C>G	uc002ppm.2	-	9	1502	c.1491G>C	c.(1489-1491)AAG>AAC	p.K497N		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	497							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GTACCAGAATCTTCTTGTGTA	0.582													0	0	0	0.013114	0	43	70										G	50245148	C	G	50245148	3	3	46	1	0	0	0	0	1	0	0	0	16623	912	32	1	299	1	TSKS	19	50245148	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1747	50245148	8883835	1603	13300										
IL4I1	259307	broad.mit.edu	37	chr19	50393764	50393764	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtgcggtccctgggtcatCgccaccacgggcgcgttcaa	13	15	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50393764C>T	uc002pqt.1	-	8	945	c.867G>A	c.(865-867)GCG>GCA	p.A289A	IL4I1_uc002pqv.1_Silent_p.A298A|IL4I1_uc010eno.1_Silent_p.A297A|IL4I1_uc002pqw.1_Silent_p.A297A|IL4I1_uc002pqu.1_Silent_p.A311A	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	289						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CCTGGGTCATCGCCACCACGG	0.682											OREG0025629	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	14										T	50393764	C	T	50393764	2	4	46	1	0	0	0	0	0	0	0	1	7697	871	31	1		1	IL4I1	19	50393764	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	148616	50393764	8735219	1604	13301										
NUP62	23636	broad.mit.edu	37	chr19	50412045	50412045	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggtcctctagctccaggctCcatttgttgatcaggctctc	9	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50412045C>A	uc002pqx.2	-	2	1124	c.1020G>T	c.(1018-1020)TGG>TGT	p.W340C	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.W340C|NUP62_uc002pqz.2_Missense_Mutation_p.W340C|NUP62_uc002pra.2_Missense_Mutation_p.W340C|NUP62_uc002prb.2_Missense_Mutation_p.W340C|NUP62_uc002prc.2_Intron	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	340	Potential.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GCTCCAGGCTCCATTTGTTGA	0.647													1	0	2.73361e-28	0.01441	2.89787e-28	66	99										A	50412045	C	A	50412045	3	1	46	1	0	0	0	0	1	0	0	0	10768	856	30	3	552	3	NUP62	19	50412045	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	18281	50412045	8716938	1605	13302										
JOSD2	126119	broad.mit.edu	37	chr19	51009492	51009492	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggtcactaccagcagcacctCgcacaggccctgggccagcg	12	17	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51009492C>T	uc002psn.1	-	5	536	c.505G>A	c.(505-507)GAG>AAG	p.E169K	JOSD2_uc002pso.1_Missense_Mutation_p.E169K|JOSD2_uc002psp.1_Missense_Mutation_p.E169K|JOSD2_uc002psq.1_Missense_Mutation_p.E127K	NM_138334	NP_612207	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	169	Josephin.				protein deubiquitination		ubiquitin-specific protease activity				0		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		AGCAGCACCTCGCACAGGCCC	0.682													0	0	0	0.001168	0	6	42										T	51009492	C	T	51009492	3	4	46	1	0	0	0	0	1	0	0	0	7959	893	31	1	65	1	JOSD2	19	51009492	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	597447	51009492	8119491	1606	13303										
SHANK1	50944	broad.mit.edu	37	chr19	51219555	51219555	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggtaggggacccccttctCaaaggactgggggtactccc	13	13	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51219555C>G	uc002psx.1	-	2	455	c.436G>C	c.(436-438)GAG>CAG	p.E146Q		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	146					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACCCCCTTCTCAAAGGACTGG	0.582													0	0	0	0.01441	0	47	75										G	51219555	C	G	51219555	3	3	46	1	0	0	0	0	1	0	0	0	14264	835	29	1	6137	1	SHANK1	19	51219555	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	210063	51219555	7909428	1607	13304										
KLK11	11012	broad.mit.edu	37	chr19	51527533	51527533	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcacagccctcctccttctgGaggttgtgctgccccaggtg	11	15	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51527533G>T	uc002pvd.1	-	4	439	c.327C>A	c.(325-327)CTC>CTA	p.L109L	KLK11_uc002pvb.1_Silent_p.L102L|KLK11_uc002pve.1_5'UTR|KLK11_uc002pvf.1_Silent_p.L77L|KLK11_uc002pvc.3_Silent_p.L77L|KLK11_uc010eom.2_Missense_Mutation_p.P79T	NM_144947	NP_659196	Q9UBX7	KLK11_HUMAN	kallikrein 11 isoform 2 precursor	109	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		CCTCCTTCTGGAGGTTGTGCT	0.602													1	0	1.38814e-16	0.01441	1.46226e-16	55	56										T	51527533	G	T	51527533	2	4	46	1	0	0	0	0	0	0	0	1	8399	1161	41	3		3	KLK11	19	51527533	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	307978	51527533	7601450	1608	13305										
SIGLEC10	89790	broad.mit.edu	37	chr19	51920200	51920200	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tagacatcaggcttctgagtCagggctgggacagagaccgt	14	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51920200C>T	uc002pwo.2	-	3	1042	c.426G>A	c.(424-426)CTG>CTA	p.L142L	SIGLEC10_uc002pwp.2_Intron|SIGLEC10_uc002pwq.2_Intron|SIGLEC10_uc002pwr.2_Silent_p.L142L|SIGLEC10_uc010ycy.1_Silent_p.L142L|SIGLEC10_uc010ycz.1_Intron|SIGLEC10_uc010eow.2_5'UTR|SIGLEC10_uc002pws.1_Intron	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	142	Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GCTTCTGAGTCAGGGCTGGGA	0.622													0	0	0	0.01441	0	90	72										T	51920200	C	T	51920200	2	4	46	1	0	0	0	0	0	0	0	1	14306	813	29	1		1	SIGLEC10	19	51920200	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	392667	51920200	7208783	1609	13306										
ZNF615	284370	broad.mit.edu	37	chr19	52498046	52498046	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cacactcttctgaatactttGattttgcaagtgatgctgca	7	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52498046G>A	uc002pye.1	-	6	575	c.283C>T	c.(283-285)CAA>TAA	p.Q95*	ZNF615_uc002pyf.1_Nonsense_Mutation_p.Q106*|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Nonsense_Mutation_p.Q106*|ZNF615_uc010epi.1_Nonsense_Mutation_p.Q102*|ZNF615_uc010ydg.1_Nonsense_Mutation_p.Q100*	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGAATACTTTGATTTTGCAAG	0.348													0	0	0	0.012319	0	21	148										A	52498046	G	A	52498046	4	1	46	1	0	0	0	0	0	1	0	0	18037	1299	45	1	1916	1	ZNF615	19	52498046	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	577846	52498046	6630937	1610	13307										
ZNF841	284371	broad.mit.edu	37	chr19	52568426	52568426	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acattgagtttagttgtaagGttctctccagcatgttttat	8	6	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52568426G>A	uc002pyl.1	-	5	2913	c.2361C>T	c.(2359-2361)AAC>AAT	p.N787N	ZNF841_uc010ydh.1_Silent_p.N903N|ZNF841_uc010epk.1_Silent_p.N479N	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	787					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGTTGTAAGGTTCTCTCCAG	0.338													0	0	0	0.006214	0	9	62										A	52568426	G	A	52568426	2	1	46	1	0	0	0	0	0	0	0	1	18186	1252	44	2		2	ZNF841	19	52568426	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	70380	52568426	6560557	1611	13308										
ZNF616	90317	broad.mit.edu	37	chr19	52618287	52618287	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatcttttctctccagtgtgGattctctggtgacttacaag	8	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52618287G>A	uc002pym.2	-	4	2413	c.2130C>T	c.(2128-2130)ATC>ATT	p.I710I	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	710	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CTCCAGTGTGGATTCTCTGGT	0.398													0	0	0	0.01441	0	50	362										A	52618287	G	A	52618287	2	1	46	1	0	0	0	0	0	0	0	1	18038	1164	41	1		1	ZNF616	19	52618287	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	49861	52618287	6510696	1612	13309										
ZNF836	162962	broad.mit.edu	37	chr19	52659824	52659824	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctggtgatttacaagattaGaattctgcctgaagaccttg	9	7	2	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52659824G>A	uc010ydi.1	-	5	1486	c.1112C>T	c.(1111-1113)TCT>TTT	p.S371F	ZNF836_uc010ydj.1_Missense_Mutation_p.S371F	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	371	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACAAGATTAGAATTCTGCCT	0.403													0	0	0	0.013726	0	34	79										A	52659824	G	A	52659824	3	1	46	1	0	0	0	0	1	0	0	0	18184	942	33	1	1700	1	ZNF836	19	52659824	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	41537	52659824	6469159	1613	13310										
ZNF836	162962	broad.mit.edu	37	chr19	52663830	52663830	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aattctatggctacatccctGaatgtcaaaggtccctgaaa	7	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52663830G>A	uc010ydi.1	-	4	404	c.30C>T	c.(28-30)TTC>TTT	p.F10F	ZNF836_uc010ydj.1_Silent_p.F10F	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACATCCCTGAATGTCAAAG	0.433													0	0	0	0.008871	0	20	174										A	52663830	G	A	52663830	2	1	46	1	0	0	0	0	0	0	0	1	18184	1281	45	1		1	ZNF836	19	52663830	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4006	52663830	6465153	1614	13311										
ZNF534	147658	broad.mit.edu	37	chr19	52937222	52937222	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttttaggggcaattgtcattCagcgatgtggccatagaatt	11	6	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52937222C>A	uc002pzk.2	+	2	91	c.30C>A	c.(28-30)TTC>TTA	p.F10L	ZNF534_uc002pzj.1_Missense_Mutation_p.F10L|ZNF534_uc010epo.1_Missense_Mutation_p.F10L|ZNF534_uc002pzl.2_Missense_Mutation_p.F10L	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATTGTCATTCAGCGATGTGG	0.443													1	0	4.7546e-09	0.004007	4.92952e-09	13	159										A	52937222	C	A	52937222	3	1	46	1	0	0	0	0	1	0	0	0	17970	825	29	3	36	3	ZNF534	19	52937222	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	273392	52937222	6191761	1615	13312										
ZNF578	147660	broad.mit.edu	37	chr19	53014288	53014288	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tttttccattcatcattactCacacaaaaacaggaagtaca	3	10	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53014288C>G	uc002pzp.3	+	6	898	c.654C>G	c.(652-654)CTC>CTG	p.L218L		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	133	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		CATCATTACTCACACAAAAAC	0.348													0	0	0	0.004656	0	27	213										G	53014288	C	G	53014288	2	3	46	1	0	0	0	0	0	0	0	1	18007	813	29	1		1	ZNF578	19	53014288	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	77066	53014288	6114695	1616	13313										
ZNF320	162967	broad.mit.edu	37	chr19	53384869	53384869	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcaagatgtgatttgcaactGaaaactttctcacattcttc	5	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53384869G>C	uc002qag.2	-	4	701	c.510C>G	c.(508-510)TTC>TTG	p.F170L	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.F116L|ZNF320_uc002qai.2_Missense_Mutation_p.F170L	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	170	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ATTTGCAACTGAAAACTTTCT	0.358													0	0	0	0.003163	0	15	205										C	53384869	G	C	53384869	3	2	46	1	0	0	0	0	1	0	0	0	17836	1281	45	1	1023	1	ZNF320	19	53384869	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	370581	53384869	5744114	1617	13314										
ZNF347	84671	broad.mit.edu	37	chr19	53644301	53644301	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attacatttataaggtttctCtccagtatgaattccccgat	5	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53644301C>T	uc002qbb.1	-	5	1849	c.1780G>A	c.(1780-1782)GAG>AAG	p.E594K	ZNF347_uc010eql.1_Missense_Mutation_p.E595K|ZNF347_uc002qbc.1_Missense_Mutation_p.E595K	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TAAGGTTTCTCTCCAGTATGA	0.398													0	0	0	0.011902	0	46	353										T	53644301	C	T	53644301	3	4	46	1	0	0	0	0	1	0	0	0	17858	922	32	1	743	1	ZNF347	19	53644301	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	259432	53644301	5484682	1618	13315										
ZNF347	84671	broad.mit.edu	37	chr19	53656992	53656992	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taatattaccttacctgggtGagagccatgcctgacttgtc	9	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53656992G>A	uc002qbb.1	-	2	78	c.9C>T	c.(7-9)CTC>CTT	p.L3L	ZNF347_uc010eql.1_Silent_p.L3L|ZNF347_uc002qbc.1_Silent_p.L3L	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TTACCTGGGTGAGAGCCATGC	0.398													0	0	0	0.010818	0	28	238										A	53656992	G	A	53656992	2	1	46	1	0	0	0	0	0	0	0	1	17858	1277	45	1		1	ZNF347	19	53656992	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	12691	53656992	5471991	1619	13316										
PRPF31	26121	broad.mit.edu	37	chr19	54628017	54628017	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tacatctaccacagtgacatCgtgcagtccctgccaccggt	8	15	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54628017C>T	uc002qdh.2	+	8	1233	c.837C>T	c.(835-837)ATC>ATT	p.I279I	PRPF31_uc010yek.1_Silent_p.I279I	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	279	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding	p.I279I(1)		ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACAGTGACATCGTGCAGTCCC	0.672													0	0	0	0.001984	0	7	64										T	54628017	C	T	54628017	2	4	46	1	0	0	0	0	0	0	0	1	12566	874	31	1		1	PRPF31	19	54628017	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	971025	54628017	4500966	1620	13317										
CNOT3	4849	broad.mit.edu	37	chr19	54649696	54649696	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gccacagccacatggaggatGagatcttcaaccagtccagc	10	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54649696G>T	uc002qdj.1	+	9	1065	c.754G>T	c.(754-756)GAG>TAG	p.E252*	CNOT3_uc010yel.1_Nonsense_Mutation_p.E252*|CNOT3_uc002qdi.2_Nonsense_Mutation_p.E165*|CNOT3_uc002qdk.1_Nonsense_Mutation_p.E252*|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	252					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CATGGAGGATGAGATCTTCAA	0.642													1	0	1.10513e-12	0.014323	1.15629e-12	17	73										T	54649696	G	T	54649696	4	4	46	1	0	0	0	0	0	1	0	0	3620	1291	45	3	784	3	CNOT3	19	54649696	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	21679	54649696	4479287	1621	13318										
TMC4	147798	broad.mit.edu	37	chr19	54664083	54664083	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggtcagcgccacagcgcgcCgtgccaggaagactttattc	12	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54664083C>T	uc010erf.2	-	15	2231	c.2099G>A	c.(2098-2100)CGG>CAG	p.R700Q	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Missense_Mutation_p.R414Q|TMC4_uc002qdo.2_Missense_Mutation_p.R694Q	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	700	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CACAGCGCGCCGTGCCAGGAA	0.572													0	0	0	0.009535	0	30	235										T	54664083	C	T	54664083	3	4	46	1	0	0	0	0	1	0	0	0	15984	652	23	2	43	2	TMC4	19	54664083	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	14387	54664083	4464900	1622	13319										
TMC4	147798	broad.mit.edu	37	chr19	54666432	54666432	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaaactggatgagcagcgcGactgccaagacagtcagcag	14	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54666432G>A	uc010erf.2	-	10	1626	c.1494C>T	c.(1492-1494)GTC>GTT	p.V498V	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Silent_p.V212V|TMC4_uc002qdo.2_Silent_p.V492V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	498	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGAGCAGCGCGACTGCCAAGA	0.547													0	0	0	0.009096	0	4	36										A	54666432	G	A	54666432	2	1	46	1	0	0	0	0	0	0	0	1	15984	1045	37	1		1	TMC4	19	54666432	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2349	54666432	4462551	1623	13320										
LILRA5	353514	broad.mit.edu	37	chr19	54823808	54823808	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgaggcttccaatctcaccGaggcagagcagaaccatgag	11	12	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54823808G>A	uc002qfe.2	-	2	207	c.87C>T	c.(85-87)CTC>CTT	p.L29L	LILRA5_uc002qff.2_Silent_p.L29L|LILRA5_uc010yev.1_Silent_p.L29L|LILRA5_uc010yew.1_Silent_p.L29L|LILRA5_uc002qfh.1_Silent_p.L29L|LILRA5_uc002qfg.1_Silent_p.L29L	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	29					innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAATCTCACCGAGGCAGAGCA	0.602													0	0	0	0.004482	0	8	71										A	54823808	G	A	54823808	2	1	46	1	0	0	0	0	0	0	0	1	8788	1072	37	1		1	LILRA5	19	54823808	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	157376	54823808	4305175	1624	13321										
LENG9	94059	broad.mit.edu	37	chr19	54973372	54973372	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcaccccacttcctggctGagggtgaactccagcttggg	13	13	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54973372G>A	uc010yez.1	-	1	1523	c.1404C>T	c.(1402-1404)CTC>CTT	p.L468L		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	468					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		CTTCCTGGCTGAGGGTGAACT	0.647													0	0	0	0.01441	0	92	96										A	54973372	G	A	54973372	2	1	46	1	0	0	0	0	0	0	0	1	8725	1277	45	1		1	LENG9	19	54973372	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	149564	54973372	4155611	1625	13322										
NLRP2	55655	broad.mit.edu	37	chr19	55508802	55508802	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccttggggtctagtggagtGaagatgctgtttgaaacctt	13	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55508802G>A	uc002qij.2	+	12	3083	c.2997G>A	c.(2995-2997)GTG>GTA	p.V999V	NLRP2_uc010yfp.1_Silent_p.V976V|NLRP2_uc010esn.2_Silent_p.V975V|NLRP2_uc010eso.2_Silent_p.V996V|NLRP2_uc010esp.2_Silent_p.V977V	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	999	LRR 7.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTAGTGGAGTGAAGATGCTGT	0.537													0	0	0	0.01441	0	187	158										A	55508802	G	A	55508802	2	1	46	1	0	0	0	0	0	0	0	1	10477	1277	45	1		1	NLRP2	19	55508802	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	535430	55508802	3620181	1626	13323										
C19orf51	352909	broad.mit.edu	37	chr19	55670468	55670468	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtctgactcacagttgggcgGagccaaggccccctgaggct	14	13	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55670468G>A	uc002qji.1	-	12	1622	c.1588C>T	c.(1588-1590)CCG>TCG	p.P530S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.P345S|C19orf51_uc002qjj.1_Missense_Mutation_p.P577S|C19orf51_uc002qjk.1_Missense_Mutation_p.P476S|C19orf51_uc002qjl.1_Missense_Mutation_p.P597S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	530											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CAGTTGGGCGGAGCCAAGGCC	0.587													0	0	0	0.01441	0	52	31										A	55670468	G	A	55670468	3	1	46	1	0	0	0	0	1	0	0	0	1933	1174	41	1	41	1	C19orf51	19	55670468	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	161666	55670468	3458515	1627	13324										
SYT5	6861	broad.mit.edu	37	chr19	55686347	55686347	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acatagcggagggagaagcaGatgtccccaagcttctcctg	12	11	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55686347G>C	uc002qjm.1	-	6	1789	c.729C>G	c.(727-729)ATC>ATG	p.I243M	SYT5_uc002qjp.2_Missense_Mutation_p.I239M|SYT5_uc002qjn.1_Missense_Mutation_p.I243M|SYT5_uc002qjo.1_Missense_Mutation_p.I242M	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	243	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGGAGAAGCAGATGTCCCCAA	0.607													0	0	0	0.01441	0	68	28										C	55686347	G	C	55686347	3	2	46	1	0	0	0	0	1	0	0	0	15474	932	33	1	443	1	SYT5	19	55686347	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	15879	55686347	3442636	1628	13325										
UBE2S	27338	broad.mit.edu	37	chr19	55912936	55912936	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctggggccccagggtcggtGgaggaagcttcagtgccact	16	12	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55912936G>A	uc002qkx.1	-	4	905	c.537C>T	c.(535-537)TCC>TCT	p.S179S		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	179					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		CAGGGTCGGTGGAGGAAGCTT	0.711													0	0	0	0.000602	0	3	30										A	55912936	G	A	55912936	2	1	46	1	0	0	0	0	0	0	0	1	16869	1335	47	2		2	UBE2S	19	55912936	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	226589	55912936	3216047	1629	13326										
NLRP4	147945	broad.mit.edu	37	chr19	56369323	56369323	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcctgtacacgttctatttCtgctgcagagaactgaggga	10	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:56369323C>A	uc002qmd.3	+	3	986	c.564C>A	c.(562-564)TTC>TTA	p.F188L	NLRP4_uc002qmf.2_Missense_Mutation_p.F113L|NLRP4_uc010etf.2_Missense_Mutation_p.F19L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	188	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CGTTCTATTTCTGCTGCAGAG	0.507													1	0	1.01871e-10	0.008871	1.06177e-10	21	225										A	56369323	C	A	56369323	3	1	46	1	0	0	0	0	1	0	0	0	10479	912	32	3	570	3	NLRP4	19	56369323	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	456387	56369323	2759660	1630	13327										
ZNF71	58491	broad.mit.edu	37	chr19	57132856	57132856	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	attccccaggggaacaaactCttagggggctcagtacccgc	11	13	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:57132856C>G	uc002qnm.3	+	3	439	c.201C>G	c.(199-201)CTC>CTG	p.L67L		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	67						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGAACAAACTCTTAGGGGGCT	0.607													0	0	0	0.006214	0	9	73										G	57132856	C	G	57132856	2	3	46	1	0	0	0	0	0	0	0	1	18111	900	32	1		1	ZNF71	19	57132856	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	763533	57132856	1996127	1631	13328										
AURKC	6795	broad.mit.edu	37	chr19	57743573	57743573	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagctgcgccgggaaattGagatccaggctcatctacag	11	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:57743573G>C	uc002qoe.2	+	3	466	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	AURKC_uc002qoc.2_Missense_Mutation_p.E74Q|AURKC_uc002qod.2_Missense_Mutation_p.E59Q|AURKC_uc010etv.2_Missense_Mutation_p.E90Q	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	93	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CCGGGAAATTGAGATCCAGGC	0.507													0	0	0	0.004482	0	8	97										C	57743573	G	C	57743573	3	2	46	1	0	0	0	0	1	0	0	0	1224	1291	45	1	292	1	AURKC	19	57743573	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	610717	57743573	1385410	1632	13329										
ZNF548	147694	broad.mit.edu	37	chr19	57911012	57911012	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaggccttacgagtgcagaGagtgtgggaaagcctttagc	14	7	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:57911012G>C	uc002qom.2	+	3	1607	c.1357G>C	c.(1357-1359)GAG>CAG	p.E453Q	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.E456Q	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	453	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGAGTGCAGAGAGTGTGGGAA	0.463													0	0	0	0.013537	0	13	113										C	57911012	G	C	57911012	3	2	46	1	0	0	0	0	1	0	0	0	17977	943	33	1	1407	1	ZNF548	19	57911012	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	167439	57911012	1217971	1633	13330										
ZSCAN4	201516	broad.mit.edu	37	chr19	58187526	58187526	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctaagaatggctttagatCtaagaaccatatttcagtgt	8	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58187526C>A	uc002qpu.2	+	3	710	c.13C>A	c.(13-15)CTA>ATA	p.L5I		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	5					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGCTTTAGATCTAAGAACCAT	0.398													1	0	2.94398e-08	0.007413	3.04067e-08	19	116										A	58187526	C	A	58187526	3	1	46	1	0	0	0	0	1	0	0	0	18234	912	32	3	15	3	ZSCAN4	19	58187526	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	276514	58187526	941457	1634	13331										
ZNF417	147687	broad.mit.edu	37	chr19	58421054	58421054	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtgggccatgcatagtttCactgtctgtcttctctacag	11	10	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58421054C>T	uc002qqq.2	-	3	791	c.592G>A	c.(592-594)GAA>AAA	p.E198K	ZNF417_uc010yhm.1_Missense_Mutation_p.E155K|ZNF417_uc002qqr.2_Missense_Mutation_p.E197K	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		TGCATAGTTTCACTGTCTGTC	0.488													0	0	0	0.011902	0	37	69										T	58421054	C	T	58421054	3	4	46	1	0	0	0	0	1	0	0	0	17891	835	29	1	1139	1	ZNF417	19	58421054	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	233528	58421054	707929	1635	13332										
ZNF256	10172	broad.mit.edu	37	chr19	58452322	58452322	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaacgttctgatgttttagGaggttggagttgaaggtaaa	14	2	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58452322G>A	uc002qqu.2	-	3	2089	c.1854C>T	c.(1852-1854)CTC>CTT	p.L618L	ZNF256_uc010euj.2_Silent_p.L465L	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	618	C2H2-type 15.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GATGTTTTAGGAGGTTGGAGT	0.428													0	0	0	0.014323	0	21	74										A	58452322	G	A	58452322	2	1	46	1	0	0	0	0	0	0	0	1	17796	1161	41	1		1	ZNF256	19	58452322	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	31268	58452322	676661	1636	13333										
ZNF256	10172	broad.mit.edu	37	chr19	58453721	58453721	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctgctcaaaaacatgtctCtgcccccattgcttctgaag	7	13	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58453721C>G	uc002qqu.2	-	3	690	c.455G>C	c.(454-456)AGA>ACA	p.R152T	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	152					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		AAACATGTCTCTGCCCCCATT	0.458													0	0	0	0.013726	0	34	100										G	58453721	C	G	58453721	3	3	46	1	0	0	0	0	1	0	0	0	17796	913	32	1	1432	1	ZNF256	19	58453721	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1399	58453721	675262	1637	13334										
ZNF544	27300	broad.mit.edu	37	chr19	58773587	58773587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttccaaacttattacgcatCagcgaattcacactggagaa	7	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58773587C>G	uc010euo.2	+	7	2089	c.1615C>G	c.(1615-1617)CAG>GAG	p.Q539E	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.Q511E|ZNF544_uc010yhy.1_Missense_Mutation_p.Q511E|ZNF544_uc002qrt.3_Missense_Mutation_p.Q397E|ZNF544_uc002qru.3_Missense_Mutation_p.Q397E|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	539	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TATTACGCATCAGCGAATTCA	0.443													0	0	0	0.01441	0	57	52										G	58773587	C	G	58773587	3	3	46	1	0	0	0	0	1	0	0	0	17974	827	29	1	1629	1	ZNF544	19	58773587	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	319866	58773587	355396	1638	13335										
RSPO4	343637	broad.mit.edu	37	chr20	947851	947851	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgttctggtgggccaaagtGcccggcgggcaggtgggcag	20	9	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:947851G>A	uc002wej.2	-	3	472	c.375C>T	c.(373-375)GGC>GGT	p.G125G	RSPO4_uc002wek.2_Silent_p.G125G	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	125	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding				0						GGGCCAAAGTGCCCGGCGGGC	0.652													0	0	0	0.008291	0	9	27										A	947851	G	A	947851	2	1	46	1	0	0	0	0	0	0	0	1	13712	1306	46	2		2	RSPO4	20	947851	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		947851	62077669	1639	13336										
SIRPG	55423	broad.mit.edu	37	chr20	1629746	1629746	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agacttaaactccacgttctCagggctcccttttcgaaact	6	13	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:1629746C>T	uc002wfm.1	-	2	447	c.382G>A	c.(382-384)GAG>AAG	p.E128K	SIRPG_uc002wfn.1_Missense_Mutation_p.E128K|SIRPG_uc002wfo.1_Missense_Mutation_p.E128K	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	128	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						TCCACGTTCTCAGGGCTCCCT	0.488													0	0	0	0.01441	0	47	164										T	1629746	C	T	1629746	3	4	46	1	0	0	0	0	1	0	0	0	14336	835	29	1	797	1	SIRPG	20	1629746	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	681895	1629746	61395774	1640	13337										
TGM6	343641	broad.mit.edu	37	chr20	2413155	2413155	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgtgcctaccctggagcctCaggagagggcctcagtccag	14	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:2413155C>T	uc002wfy.1	+	13	2048	c.1987C>T	c.(1987-1989)CAG>TAG	p.Q663*	TGM6_uc010gal.1_Missense_Mutation_p.S618L	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	663					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCTGGAGCCTCAGGAGAGGGC	0.607													0	0	0	0.008871	0	18	55										T	2413155	C	T	2413155	4	4	46	1	0	0	0	0	0	1	0	0	15831	827	29	1	2037	1	TGM6	20	2413155	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	783409	2413155	60612365	1641	13338										
PTPRA	5786	broad.mit.edu	37	chr20	2945569	2945569	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cggcagaaccagttaaagaaGaggccaaaacttcaaatcca	8	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:2945569G>C	uc010zqb.1	+	5	529	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	PTPRA_uc002whj.2_Missense_Mutation_p.E46Q|PTPRA_uc010zqc.1_Intron|PTPRA_uc002whk.2_Missense_Mutation_p.E46Q|PTPRA_uc010zqd.1_Missense_Mutation_p.E57Q|PTPRA_uc002whl.2_Missense_Mutation_p.E46Q|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Missense_Mutation_p.E46Q			P18433	PTPRA_HUMAN	SubName: Full=cDNA FLJ60525, highly similar to Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48);	46	Extracellular (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						AGTTAAAGAAGAGGCCAAAAC	0.388													0	0	0	0.009535	0	31	71										C	2945569	G	C	2945569	3	2	46	1	0	0	0	0	1	0	0	0	12795	943	33	1	142	1	PTPRA	20	2945569	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	532414	2945569	60079951	1642	13339										
PTPRA	5786	broad.mit.edu	37	chr20	2968991	2968991	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgtgtactgcagagccccaGagtgtgccacttctggccag	12	12	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:2968991G>A	uc010zqd.1	+	8	959	c.642G>A	c.(640-642)CAG>CAA	p.Q214Q	PTPRA_uc002whj.2_Silent_p.Q203Q|PTPRA_uc010zqc.1_Silent_p.Q88Q|PTPRA_uc002whk.2_Silent_p.Q194Q|PTPRA_uc002whl.2_Silent_p.Q194Q|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Silent_p.Q194Q|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	203	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.T214I(1)		upper_aerodigestive_tract(1)	1						CAGAGCCCCAGAGTGTGCCAC	0.567													0	0	0	0.00333	0	22	82										A	2968991	G	A	2968991	2	1	46	1	0	0	0	0	0	0	0	1	12795	933	33	1		1	PTPRA	20	2968991	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	23422	2968991	60056529	1643	13340										
ADAM33	80332	broad.mit.edu	37	chr20	3655675	3655675	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccatggaagcatctcaccGtgtggttgggggccagcacc	14	13	1	0	rs146682885		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:3655675G>A	uc002wit.2	-	4	419	c.332C>T	c.(331-333)ACG>ATG	p.T111M	ADAM33_uc002wir.1_Missense_Mutation_p.T111M|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.T111M|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Missense_Mutation_p.T110M|ADAM33_uc010zqg.1_Missense_Mutation_p.T110M|ADAM33_uc010zqh.1_Missense_Mutation_p.T111M	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	111	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						GCATCTCACCGTGTGGTTGGG	0.622													0	0	0	0.008291	0	10	17										A	3655675	G	A	3655675	3	1	46	1	0	0	0	0	1	0	0	0	250	1159	40	2	2185	2	ADAM33	20	3655675	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	686684	3655675	59369845	1644	13341										
PANK2	80025	broad.mit.edu	37	chr20	3891268	3891268	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggatgaactagattgcttGatcaaaggaattttatacat	8	5	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:3891268G>A	uc002wkc.2	+	3	1032	c.1026G>A	c.(1024-1026)TTG>TTA	p.L342L	PANK2_uc002wkb.2_Silent_p.L51L|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_Silent_p.L51L|PANK2_uc002wkf.2_5'UTR	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	342					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TAGATTGCTTGATCAAAGGAA	0.353													0	0	0	0.01441	0	71	116										A	3891268	G	A	3891268	2	1	46	1	0	0	0	0	0	0	0	1	11417	1281	45	1		1	PANK2	20	3891268	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	235593	3891268	59134252	1645	13342										
ADRA1D	146	broad.mit.edu	37	chr20	4202235	4202235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcctggcaggtggcgccctCggccacctcgtgtgggacgc	17	15	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:4202235C>T	uc002wkr.2	-	2	1709	c.1654G>A	c.(1654-1656)GAG>AAG	p.E552K		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	552	Cytoplasmic (By similarity).			KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRA EAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRET DI -> SHPAPSASGGCWGRSGDPRPSCAPKSPACRTRSPP GARSAQRQRAPSAQRWRLCP (in Ref. 1).	cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	GTGGCGCCCTCGGCCACCTCG	0.682													0	0	0	0.001984	0	7	34										T	4202235	C	T	4202235	3	4	46	1	0	0	0	0	1	0	0	0	336	893	31	1	68	1	ADRA1D	20	4202235	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	310967	4202235	58823285	1646	13343										
GPCPD1	56261	broad.mit.edu	37	chr20	5556510	5556510	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atttctgctcatgatgggaaGagtaagaattccagcactct	9	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:5556510G>C	uc002wme.3	-	9	1033	c.820C>G	c.(820-822)CTT>GTT	p.L274V	GPCPD1_uc002wmd.3_Missense_Mutation_p.L93V	NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	274					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0						ATGATGGGAAGAGTAAGAATT	0.438													0	0	0	0.008361	0	31	130										C	5556510	G	C	5556510	3	2	46	1	0	0	0	0	1	0	0	0	6603	942	33	1	1246	1	GPCPD1	20	5556510	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1354275	5556510	57469010	1647	13344										
MCM8	84515	broad.mit.edu	37	chr20	5935298	5935298	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgagaagattcaagcatttGaaaaatttttcacaaggcat	7	5	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:5935298G>C	uc002wmi.2	+	4	675	c.298G>C	c.(298-300)GAA>CAA	p.E100Q	MCM8_uc002wmj.2_Missense_Mutation_p.E100Q|MCM8_uc002wmk.2_Missense_Mutation_p.E100Q|MCM8_uc002wml.2_Missense_Mutation_p.E100Q|MCM8_uc010gbp.2_Missense_Mutation_p.E100Q	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	100					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						TCAAGCATTTGAAAAATTTTT	0.363													0	0	0	0.00499	0	17	73										C	5935298	G	C	5935298	3	2	46	1	0	0	0	0	1	0	0	0	9393	1291	45	1	308	1	MCM8	20	5935298	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	378788	5935298	57090222	1648	13345										
JAG1	182	broad.mit.edu	37	chr20	10625512	10625512	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggggggaggacactcactCtgagcacagatgggcccctc	14	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:10625512C>T	uc002wnw.2	-	18	2859	c.2343G>A	c.(2341-2343)CAG>CAA	p.Q781Q	JAG1_uc010gcd.1_Silent_p.Q339Q	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	781	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GACACTCACTCTGAGCACAGA	0.592									Alagille_Syndrome				0	0	0	0.01441	0	50	96										T	10625512	C	T	10625512	2	4	46	1	0	0	0	0	0	0	0	1	7934	927	32	1		1	JAG1	20	10625512	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4690214	10625512	52400008	1649	13346										
TASP1	55617	broad.mit.edu	37	chr20	13550189	13550189	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taggagggcaagagggtattCcatgatctactgcccatctg	12	9	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:13550189C>T	uc002woi.2	-	7	650	c.533G>A	c.(532-534)GGA>GAA	p.G178E	TASP1_uc010zri.1_Intron|TASP1_uc002woh.2_Missense_Mutation_p.G155E|TASP1_uc010zrj.1_Intron	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	178					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						AGAGGGTATTCCATGATCTAC	0.333													0	0	0	0.005443	0	21	98										T	13550189	C	T	13550189	3	4	46	1	0	0	0	0	1	0	0	0	15586	855	30	1	761	1	TASP1	20	13550189	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2924677	13550189	49475331	1650	13347										
KIF16B	55614	broad.mit.edu	37	chr20	16362382	16362382	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcttcacgctgttgcctctCaaattcaagtctaataaaat	4	10	5	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:16362382C>T	uc002wpg.1	-	18	1953	c.1795G>A	c.(1795-1797)GAG>AAG	p.E599K	KIF16B_uc002wpe.1_5'Flank|KIF16B_uc002wpf.1_5'Flank|KIF16B_uc010gch.1_Missense_Mutation_p.E599K|KIF16B_uc010gci.1_Missense_Mutation_p.E599K|KIF16B_uc010gcj.1_Missense_Mutation_p.E610K	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	599	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TGTTGCCTCTCAAATTCAAGT	0.343													0	0	0	0.008291	0	10	43										T	16362382	C	T	16362382	3	4	46	1	0	0	0	0	1	0	0	0	8278	835	29	1	2194	1	KIF16B	20	16362382	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2812193	16362382	46663138	1651	13348										
BFSP1	631	broad.mit.edu	37	chr20	17479526	17479526	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcattcttcagggtttgctGggcgaccgccagctgccggc	13	14	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:17479526G>A	uc002wpo.2	-	6	934	c.895C>T	c.(895-897)CAG>TAG	p.Q299*	BFSP1_uc002wpp.2_Nonsense_Mutation_p.Q174*|BFSP1_uc010zrn.1_Nonsense_Mutation_p.Q160*|BFSP1_uc010zro.1_Nonsense_Mutation_p.Q160*	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	299	Rod.|Coil 2.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						AGGGTTTGCTGGGCGACCGCC	0.532													0	0	0	0.007413	0	19	24										A	17479526	G	A	17479526	4	1	46	1	0	0	0	0	0	1	0	0	1415	1357	47	2	1114	2	BFSP1	20	17479526	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1117144	17479526	45545994	1652	13349										
C20orf72	92667	broad.mit.edu	37	chr20	17950541	17950541	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagaccatttgcaggcagctCaggagttcaaagttttctgt	10	9	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:17950541C>G	uc002wqh.2	+	2	121	c.39C>G	c.(37-39)CTC>CTG	p.L13L	C20orf72_uc010gco.2_RNA|C20orf72_uc010gcp.2_5'Flank|SNX5_uc002wqc.2_5'Flank|SNX5_uc002wqd.2_5'Flank|SNX5_uc002wqe.2_5'Flank|SNX5_uc010zrt.1_5'Flank|SNX5_uc010gcn.1_5'Flank	NM_052865	NP_443097	Q9BQP7	CT072_HUMAN	hypothetical protein LOC92667	13											0						GCAGGCAGCTCAGGAGTTCAA	0.408													0	0	0	0.012319	0	20	83										G	17950541	C	G	17950541	2	3	46	1	0	0	0	0	0	0	0	1	2118	813	29	1		1	C20orf72	20	17950541	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	471015	17950541	45074979	1653	13350										
CSRP2BP	57325	broad.mit.edu	37	chr20	18162455	18162455	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggaccagagtattgtcagCccttatacctctcggatctt	9	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:18162455C>T	uc002wqj.2	+	8	2395	c.1773C>T	c.(1771-1773)AGC>AGT	p.S591S	CSRP2BP_uc002wqk.2_Silent_p.S463S|CSRP2BP_uc010zru.1_Silent_p.S462S	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	591					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						GTATTGTCAGCCCTTATACCT	0.458													0	0	0	0.007413	0	20	114										T	18162455	C	T	18162455	2	4	46	1	0	0	0	0	0	0	0	1	3968	738	26	2		2	CSRP2BP	20	18162455	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	211914	18162455	44863065	1654	13351										
SLC24A3	57419	broad.mit.edu	37	chr20	19565642	19565642	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acctcagtgaagatgtggctGgggccacattcatggcagcg	14	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:19565642G>A	uc002wrl.2	+	5	648	c.451G>A	c.(451-453)GGG>AGG	p.G151R		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	151	Cytoplasmic (Potential).|Alpha-1.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						AGATGTGGCTGGGGCCACATT	0.552													0	0	0	0.00333	0	16	54										A	19565642	G	A	19565642	3	1	46	1	0	0	0	0	1	0	0	0	14467	1348	47	2	469	2	SLC24A3	20	19565642	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1403187	19565642	43459878	1655	13352										
PAX1	5075	broad.mit.edu	37	chr20	21687492	21687492	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggcgcagcccggaccgtacGaggcaagtaagcagccgccg	15	14	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:21687492G>A	uc002wsj.2	+	2	757	c.703G>A	c.(703-705)GAG>AAG	p.E235K	PAX1_uc010zsl.1_Missense_Mutation_p.E235K|PAX1_uc010zsm.1_Missense_Mutation_p.E211K	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	235					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CGGACCGTACGAGGCAAGTAA	0.647													0	0	0	0.008291	0	5	9										A	21687492	G	A	21687492	3	1	46	1	0	0	0	0	1	0	0	0	11478	1059	37	1	709	1	PAX1	20	21687492	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2121850	21687492	41338028	1656	13353										
CST9L	128821	broad.mit.edu	37	chr20	23549008	23549008	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctcgtggaaatgccaggcaTagatcagcaggatctgggag	15	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:23549008T>C	uc002wtk.3	-	1	379	c.80A>G	c.(79-81)TAT>TGT	p.Y27C		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	27						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					ATGCCAGGCATAGATCAGCAG	0.567													0	0	0	0.00499	0	18	33										C	23549008	T	C	23549008	3	2	46	1	0	0	0	0	1	0	0	0	3980	1406	49	5	375	5	CST9L	20	23549008	Missense_Mutation	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	1861516	23549008	39476512	1657	13354										
CST1	1469	broad.mit.edu	37	chr20	23728490	23728490	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggatttcaccagggaccttCtgttctcccagggaacttcg	10	12	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:23728490C>G	uc002wtp.2	-	3	460	c.389G>C	c.(388-390)AGA>ACA	p.R130T		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	130						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					CAGGGACCTTCTGTTCTCCCA	0.542													0	0	0	0.001855	0	13	41										G	23728490	C	G	23728490	3	3	46	1	0	0	0	0	1	0	0	0	3970	913	32	1	40	1	CST1	20	23728490	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	179482	23728490	39297030	1658	13355										
ACSS1	84532	broad.mit.edu	37	chr20	24994205	24994205	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagtaggcgtccacaaatcGctggtggtcgccatagatgg	14	9	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:24994205G>A	uc002wub.2	-	10	2424	c.1546C>T	c.(1546-1548)CGA>TGA	p.R516*	ACSS1_uc002wuc.2_Nonsense_Mutation_p.R514*|ACSS1_uc010gdc.2_Nonsense_Mutation_p.R311*|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Nonsense_Mutation_p.R433*	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	516					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCCACAAATCGCTGGTGGTCG	0.592													0	0	0	0.000602	0	5	15										A	24994205	G	A	24994205	4	1	46	1	0	0	0	0	0	1	0	0	188	1095	38	2	543	2	ACSS1	20	24994205	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1265715	24994205	38031315	1659	13356										
DEFB123	245936	broad.mit.edu	37	chr20	30037947	30037947	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgcgtgaagcccaagtaCcagccaaaagaaaggtggtg	13	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30037947C>A	uc002wvy.2	+	2	265	c.174C>A	c.(172-174)TAC>TAA	p.Y58*		NM_153324	NP_697019	Q8N688	DB123_HUMAN	defensin, beta 123 precursor	58					defense response to bacterium	extracellular region					0	Lung NSC(7;0.000139)|all_lung(7;0.000197)|all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			AGCCCAAGTACCAGCCAAAAG	0.423													1	0	5.01169e-05	0.00499	5.11301e-05	15	77										A	30037947	C	A	30037947	4	1	46	1	0	0	0	0	0	1	0	0	4409	518	18	4	180	4	DEFB123	20	30037947	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5043742	30037947	32987573	1660	13357										
BCL2L1	598	broad.mit.edu	37	chr20	30309932	30309932	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcctcagtcctgttctcttcCacatcactaaactgactcca	4	16	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30309932C>T	uc002wwl.2	-	2	456	c.90G>A	c.(88-90)GTG>GTA	p.V30V	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Silent_p.V30V|BCL2L1_uc002wwn.2_Silent_p.V30V|BCL2L1_uc002wwo.1_Silent_p.V30V	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	30					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			TGTTCTCTTCCACATCACTAA	0.527													0	0	0	0.01441	0	61	77										T	30309932	C	T	30309932	2	4	46	1	0	0	0	0	0	0	0	1	1367	581	21	2		2	BCL2L1	20	30309932	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	271985	30309932	32715588	1661	13358										
FOXS1	2307	broad.mit.edu	37	chr20	30432733	30432733	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaggtggccacggggagctCccctgggcatgcaggcttgg	18	11	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30432733C>T	uc002wwt.1	-	1	688	c.613G>A	c.(613-615)GAG>AAG	p.E205K		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	205					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						ACGGGGAGCTCCCCTGGGCAT	0.612													0	0	0	0.009096	0	4	36										T	30432733	C	T	30432733	3	4	46	1	0	0	0	0	1	0	0	0	6035	864	30	1	383	1	FOXS1	20	30432733	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	122801	30432733	32592787	1662	13359										
XKR7	343702	broad.mit.edu	37	chr20	30556321	30556321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttccgctggttcgtctacGactactcggagcccgcaggg	13	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30556321G>A	uc002wxe.2	+	1	517	c.343G>A	c.(343-345)GAC>AAC	p.D115N		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	115						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTTCGTCTACGACTACTCGGA	0.642													0	0	0	0.00308	0	8	10										A	30556321	G	A	30556321	3	1	46	1	0	0	0	0	1	0	0	0	17433	1058	37	1	345	1	XKR7	20	30556321	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	123588	30556321	32469199	1663	13360										
TM9SF4	9777	broad.mit.edu	37	chr20	30745699	30745699	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcttccgaaagcagccatatGacaaccctgtgcgcaccaac	8	15	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30745699G>A	uc002wxj.2	+	14	1667	c.1432G>A	c.(1432-1434)GAC>AAC	p.D478N	TM9SF4_uc010zts.1_Missense_Mutation_p.D385N|TM9SF4_uc002wxk.2_Missense_Mutation_p.D461N|TM9SF4_uc010gdz.2_Missense_Mutation_p.D357N	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	478						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCAGCCATATGACAACCCTGT	0.592													0	0	0	0.01441	0	41	57										A	30745699	G	A	30745699	3	1	46	1	0	0	0	0	1	0	0	0	15977	1290	45	1	1486	1	TM9SF4	20	30745699	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	189378	30745699	32279821	1664	13361										
CDK5RAP1	51654	broad.mit.edu	37	chr20	31946862	31946862	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctcaggtcagcaatatgcaGaagagtccctcagagtggtc	11	10	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:31946862G>C	uc010gek.2	-	15	1917	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.S494C|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.S584C|CDK5RAP1_uc002wza.2_Missense_Mutation_p.S583C|CDK5RAP1_uc010gel.2_Missense_Mutation_p.S493C|CDK5RAP1_uc010gem.2_Missense_Mutation_p.S507C|CDK5RAP1_uc002wzc.1_3'UTR|CDK5RAP1_uc002wzb.1_3'UTR	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	598					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						GCAATATGCAGAAGAGTCCCT	0.517													0	0	0	0.00245	0	15	85										C	31946862	G	C	31946862	3	2	46	1	0	0	0	0	1	0	0	0	3145	942	33	1	16	1	CDK5RAP1	20	31946862	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1201163	31946862	31078658	1665	13362										
SNTA1	6640	broad.mit.edu	37	chr20	32005554	32005554	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtcattgggggtgcacctCttcgagacatatgccatctt	12	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:32005554C>T	uc002wzd.1	-	3	944	c.672G>A	c.(670-672)AAG>AAA	p.K224K	SNTA1_uc010zuf.1_Silent_p.K224K	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	224	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GGGTGCACCTCTTCGAGACAT	0.607													0	0	0	0.00333	0	22	47										T	32005554	C	T	32005554	2	4	46	1	0	0	0	0	0	0	0	1	14871	912	32	1		1	SNTA1	20	32005554	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	58692	32005554	31019966	1666	13363										
C20orf144	128864	broad.mit.edu	37	chr20	32251342	32251342	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctgttccacccccagaccaGgatcgtgctgattctccccc	7	19	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:32251342G>A	uc002wzs.1	+	2	163	c.131G>A	c.(130-132)AGG>AAG	p.R44K	NECAB3_uc002wzl.2_5'Flank|NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron|C20orf134_uc002wzt.2_5'Flank	NM_080825	NP_543015	Q9BQM9	CT144_HUMAN	hypothetical protein LOC128864	44											0						CCCCAGACCAGGATCGTGCTG	0.726													0	0	0	0.009096	0	3	17										A	32251342	G	A	32251342	3	1	46	1	0	0	0	0	1	0	0	0	2090	1000	35	2	137	2	C20orf144	20	32251342	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	245788	32251342	30774178	1667	13364										
ITCH	83737	broad.mit.edu	37	chr20	33077105	33077105	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggaggttgtctcgaggtgttGaagaacagacacaagctttc	13	7	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33077105G>A	uc010geu.1	+	22	2443	c.2251G>A	c.(2251-2253)GAA>AAA	p.E751K	ITCH_uc002xak.2_Missense_Mutation_p.E710K|ITCH_uc010zuj.1_Missense_Mutation_p.E600K	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	751	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TCGAGGTGTTGAAGAACAGAC	0.348													0	0	0	0.009535	0	29	92										A	33077105	G	A	33077105	3	1	46	1	0	0	0	0	1	0	0	0	7868	1291	45	1	2202	1	ITCH	20	33077105	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	825763	33077105	29948415	1668	13365										
DYNLRB1	83658	broad.mit.edu	37	chr20	33114076	33114076	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcttgttttctggcaggcaGaggtggaggagacactgaag	16	6	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33114076G>A	uc002xal.2	+	2	67	c.7G>A	c.(7-9)GAG>AAG	p.E3K	DYNLRB1_uc010zuk.1_Missense_Mutation_p.E3K|DYNLRB1_uc002xam.2_RNA|DYNLRB1_uc002xan.2_Splice_Site|DYNLRB1_uc002xao.2_RNA	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Roadblock-1	3					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity				0						CTGGCAGGCAGAGGTGGAGGA	0.547													0	0	0	0.001168	0	5	33										A	33114076	G	A	33114076	3	1	46	1	0	0	0	0	1	0	0	0	4850	943	33	1	13	1	DYNLRB1	20	33114076	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	36971	33114076	29911444	1669	13366										
NCOA6	23054	broad.mit.edu	37	chr20	33346669	33346669	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggattggggcctggtgccatCatggaagatgacacatttcc	13	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33346669C>T	uc002xav.2	-	7	3153	c.582G>A	c.(580-582)ATG>ATA	p.M194I	NCOA6_uc002xaw.2_Missense_Mutation_p.M194I|NCOA6_uc010gew.1_Intron	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	194	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTGGTGCCATCATGGAAGATG	0.478													0	0	0	0.010504	0	20	90										T	33346669	C	T	33346669	3	4	46	1	0	0	0	0	1	0	0	0	10233	826	29	1	5649	1	NCOA6	20	33346669	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	232593	33346669	29678851	1670	13367										
GSS	2937	broad.mit.edu	37	chr20	33533875	33533875	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggggaccagtgaggggaaGagcgtgaatggggcatagct	19	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33533875G>A	uc002xbg.2	-	3	236	c.156C>T	c.(154-156)CTC>CTT	p.L52L	GSS_uc010zun.1_5'UTR|GSS_uc010zuo.1_Silent_p.L52L|GSS_uc010zup.1_Intron|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	52					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GTGAGGGGAAGAGCGTGAATG	0.567													0	0	0	0.005443	0	25	133										A	33533875	G	A	33533875	2	1	46	1	0	0	0	0	0	0	0	1	6829	929	33	1		1	GSS	20	33533875	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	187206	33533875	29491645	1671	13368										
TRPC4AP	26133	broad.mit.edu	37	chr20	33591402	33591402	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aggatcaccaggctggtgttGaggcagctgacgttctcctg	14	10	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33591402G>C	uc002xbk.2	-	18	2101	c.2067C>G	c.(2065-2067)CTC>CTG	p.L689L	TRPC4AP_uc002xbj.2_RNA|TRPC4AP_uc010zuq.1_Silent_p.L280L|TRPC4AP_uc002xbl.2_Silent_p.L681L|TRPC4AP_uc010zur.1_Silent_p.L650L	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	689					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GGCTGGTGTTGAGGCAGCTGA	0.662													0	0	0	0.001168	0	5	24										C	33591402	G	C	33591402	2	2	46	1	0	0	0	0	0	0	0	1	16578	1277	45	1		1	TRPC4AP	20	33591402	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	57527	33591402	29434118	1672	13369										
EIF6	3692	broad.mit.edu	37	chr20	33872046	33872046	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accacggggatggtatcggaGagctcgccctcgaacacact	12	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33872046G>A	uc002xbv.1	-	2	342	c.126C>T	c.(124-126)CTC>CTT	p.L42L	EIF6_uc002xbx.1_Silent_p.L42L|EIF6_uc002xbz.1_Missense_Mutation_p.S82F|EIF6_uc002xby.1_RNA	NM_181468	NP_852133	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	42					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGGTATCGGAGAGCTCGCCCT	0.677													0	0	0	0.003163	0	14	56										A	33872046	G	A	33872046	2	1	46	1	0	0	0	0	0	0	0	1	5045	942	33	1		1	EIF6	20	33872046	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	280644	33872046	29153474	1673	13370										
FAM83C	128876	broad.mit.edu	37	chr20	33879833	33879833	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcctgcccctgagcctcgCtgagctcagggcccccgcgc	11	21	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33879833C>T	uc010zux.1	-	1	393	c.275G>A	c.(274-276)AGC>AAC	p.S92N	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	92										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTGAGCCTCGCTGAGCTCAGG	0.662													0	0	0	0.006214	0	8	45										T	33879833	C	T	33879833	3	4	46	1	0	0	0	0	1	0	0	0	5635	797	28	2	1984	2	FAM83C	20	33879833	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	7787	33879833	29145687	1674	13371										
CEP250	11190	broad.mit.edu	37	chr20	34057761	34057761	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccagtctcagaagcaaaatGaagattatgaaaagatgata	8	6	1	6			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:34057761G>A	uc002xcm.2	+	11	1569	c.898G>A	c.(898-900)GAA>AAA	p.E300K	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_Missense_Mutation_p.E107K	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	300	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAAGCAAAATGAAGATTATGA	0.488													0	0	0	0.004878	0	34	57										A	34057761	G	A	34057761	3	1	46	1	0	0	0	0	1	0	0	0	3252	1291	45	1	924	1	CEP250	20	34057761	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	177928	34057761	28967759	1675	13372										
RBL1	5933	broad.mit.edu	37	chr20	35627227	35627227	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taaaacgtcatcattttcttGacagacgcgtttggcagggg	11	8	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:35627227G>A	uc002xgi.2	-	22	3221	c.3142C>T	c.(3142-3144)CAA>TAA	p.Q1048*	RBL1_uc010zvt.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	1048					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TCATTTTCTTGACAGACGCGT	0.398													0	0	0	0.01441	0	59	85										A	35627227	G	A	35627227	4	1	46	1	0	0	0	0	0	1	0	0	13109	1299	45	1	68	1	RBL1	20	35627227	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1569466	35627227	27398293	1676	13373										
FAM83D	81610	broad.mit.edu	37	chr20	37576568	37576568	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatctactatgcaaggtcagGaactaagattattgggaagg	11	5	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:37576568G>A	uc002xjg.2	+	3	832	c.791G>A	c.(790-792)GGA>GAA	p.G264E		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	234					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				GCAAGGTCAGGAACTAAGATT	0.438													0	0	0	0.003755	0	34	125										A	37576568	G	A	37576568	3	1	46	1	0	0	0	0	1	0	0	0	5636	1174	41	1	801	1	FAM83D	20	37576568	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1949341	37576568	25448952	1677	13374										
FAM83D	81610	broad.mit.edu	37	chr20	37576605	37576605	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggttcacgaaaagttcacGttgattgatggcatccgcgt	11	8	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:37576605G>A	uc002xjg.2	+	3	869	c.828G>A	c.(826-828)ACG>ACA	p.T276T		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	246					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AAAAGTTCACGTTGATTGATG	0.438													0	0	0	0.006122	0	19	108										A	37576605	G	A	37576605	2	1	46	1	0	0	0	0	0	0	0	1	5636	1132	40	2		2	FAM83D	20	37576605	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	37	37576605	25448915	1678	13375										
EMILIN3	90187	broad.mit.edu	37	chr20	39990348	39990348	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttccaccttgcgttcccgctCatccagggacgtgttggcag	11	14	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:39990348C>T	uc002xjy.1	-	4	2085	c.1861G>A	c.(1861-1863)GAG>AAG	p.E621K		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	621	Potential.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CGTTCCCGCTCATCCAGGGAC	0.592													0	0	0	0.008361	0	29	35										T	39990348	C	T	39990348	3	4	46	1	0	0	0	0	1	0	0	0	5095	835	29	1	443	1	EMILIN3	20	39990348	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2413743	39990348	23035172	1679	13376										
TOMM34	10953	broad.mit.edu	37	chr20	43571786	43571786	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcacttcctgccgcaacttCtgtgcaggaccattcctagg	8	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:43571786C>T	uc002xmy.2	-	7	1034	c.894G>A	c.(892-894)CAG>CAA	p.Q298Q	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	298					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				GCCGCAACTTCTGTGCAGGAC	0.507													0	0	0	0.003163	0	12	70										T	43571786	C	T	43571786	2	4	46	1	0	0	0	0	0	0	0	1	16354	912	32	1		1	TOMM34	20	43571786	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3581438	43571786	19453734	1680	13377										
STK4	6789	broad.mit.edu	37	chr20	43623860	43623860	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taactgccatagaaatggctGaaggaaagcccccttatgct	9	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:43623860G>A	uc002xnb.2	+	6	745	c.655G>A	c.(655-657)GAA>AAA	p.E219K	STK4_uc010ggx.2_Missense_Mutation_p.E219K|STK4_uc010ggy.2_Missense_Mutation_p.E164K|STK4_uc010ggw.1_Missense_Mutation_p.E219K	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	219	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				AGAAATGGCTGAAGGAAAGCC	0.443													0	0	0	0.008871	0	20	73										A	43623860	G	A	43623860	3	1	46	1	0	0	0	0	1	0	0	0	15305	1291	45	1	677	1	STK4	20	43623860	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	52074	43623860	19401660	1681	13378										
WFDC13	164237	broad.mit.edu	37	chr20	44330765	44330765	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acccatcccactgacaccatGaagcctgtgctgcctctcca	6	18	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:44330765G>A	uc002xpd.2	+	1	111	c.3G>A	c.(1-3)ATG>ATA	p.M1I	WFDC10B_uc002xpb.2_Intron|WFDC10B_uc002xpc.2_Intron	NM_172005	NP_742002	Q8IUB5	WFD13_HUMAN	WAP four-disulfide core domain 13 precursor	1						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CTGACACCATGAAGCCTGTGC	0.567													0	0	0	0.001168	0	6	15										A	44330765	G	A	44330765	3	1	46	1	0	0	0	0	1	0	0	0	17348	1290	45	1	5	1	WFDC13	20	44330765	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	706905	44330765	18694755	1682	13379										
NCOA5	57727	broad.mit.edu	37	chr20	44691177	44691186	+	Frame_Shift_Del	DEL	GGTCTGGGGC	GGTCTGGGGC	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcccttgggaaggagccccaGgtctggggcccatgttctga							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:44691177_44691186delGGTCTGGGGC	uc002xrd.2	-	7	2021_2030	c.1493_1502delGCCCCAGACC	c.(1492-1503)GGCCCCAGACCTfs	p.G498fs	NCOA5_uc002xrc.2_3'UTR|NCOA5_uc002xre.2_Frame_Shift_Del_p.G498fs	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	498_501	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				AGGAGCCCCAGGTCTGGGGCCCATGTTCTG	0.557																		24	60	---	---								-	44691186	GGTCTGGGGC	-	44691177	7	5	46	1	0	1	0	1	0	0	0	0	10232	1000	35	0	241	0	NCOA5	20	44691177	Frame_Shift_Del	DEL	GGTCTGGGGC	TCGA-DK-A1AC-01A-11D-A13W-08	360412	44691177	18334343	1683	13380										
ZMYND8	23613	broad.mit.edu	37	chr20	45976605	45976605	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aagatttttactcacctttgGagcgagtagagatatccatg	9	7	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:45976605G>A	uc002xta.1	-	2	274	c.20C>T	c.(19-21)TCC>TTC	p.S7F	ZMYND8_uc010ghr.1_Missense_Mutation_p.S7F|ZMYND8_uc002xst.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsu.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsv.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsz.1_Missense_Mutation_p.S7F|ZMYND8_uc010zxy.1_Missense_Mutation_p.S34F|ZMYND8_uc002xtb.1_Missense_Mutation_p.S27F|ZMYND8_uc002xss.2_Missense_Mutation_p.S32F|ZMYND8_uc010zxz.1_Missense_Mutation_p.S27F|ZMYND8_uc002xtc.1_Missense_Mutation_p.S27F|ZMYND8_uc002xtd.1_Missense_Mutation_p.S27F|ZMYND8_uc002xte.1_Missense_Mutation_p.S7F|ZMYND8_uc010zya.1_Missense_Mutation_p.S7F|ZMYND8_uc002xtf.1_Missense_Mutation_p.S27F|ZMYND8_uc010ghs.1_Missense_Mutation_p.S26F|ZMYND8_uc002xth.2_Missense_Mutation_p.S27F	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	7							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CTCACCTTTGGAGCGAGTAGA	0.393													0	0	0	0.01441	0	56	97										A	45976605	G	A	45976605	3	1	46	1	0	0	0	0	1	0	0	0	17708	1174	41	1	3574	1	ZMYND8	20	45976605	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1285428	45976605	17048915	1684	13381										
CSE1L	1434	broad.mit.edu	37	chr20	47675013	47675013	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctatagcaatggaactcagcGatgcaaatctgcaaacacta	7	10	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:47675013G>A	uc002xty.2	+	2	147	c.13G>A	c.(13-15)GAT>AAT	p.D5N	CSE1L_uc010zyg.1_5'UTR|CSE1L_uc010ghx.2_Missense_Mutation_p.D5N	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	5					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			GGAACTCAGCGATGCAAATCT	0.333													0	0	0	0.008871	0	19	101										A	47675013	G	A	47675013	3	1	46	1	0	0	0	0	1	0	0	0	3930	1058	37	1	15	1	CSE1L	20	47675013	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1698408	47675013	15350507	1685	13382										
SLC9A8	23315	broad.mit.edu	37	chr20	48466215	48466215	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaggaatttattttctgggtCaggtaagaaaatcatctttg	10	4	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:48466215C>T	uc002xuv.1	+	6	742	c.532C>T	c.(532-534)CAG>TAG	p.Q178*	SLC9A8_uc010zym.1_5'UTR|SLC9A8_uc010zyj.1_Nonsense_Mutation_p.Q178*|SLC9A8_uc010zyk.1_Nonsense_Mutation_p.Q178*|SLC9A8_uc010zyl.1_Nonsense_Mutation_p.Q150*|SLC9A8_uc010gib.1_Intron	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	178						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TTTTCTGGGTCAGGTAAGAAA	0.443													0	0	0	0.007291	0	29	54										T	48466215	C	T	48466215	4	4	46	1	0	0	0	0	0	1	0	0	14720	827	29	1	554	1	SLC9A8	20	48466215	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	791202	48466215	14559305	1686	13383										
CEBPB	1051	broad.mit.edu	37	chr20	48808497	48808497	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtcctggagctcacggccgaGaacgagcggctgcagaagaa	15	11	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:48808497G>A	uc002xvi.1	+	1	1122	c.927G>A	c.(925-927)GAG>GAA	p.E309E	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	309	Leucine-zipper.				acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			TCACGGCCGAGAACGAGCGGC	0.662													0	0	0	0.001984	0	5	7										A	48808497	G	A	48808497	2	1	46	1	0	0	0	0	0	0	0	1	3200	933	33	1		1	CEBPB	20	48808497	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	342282	48808497	14217023	1687	13384										
FAM65C	140876	broad.mit.edu	37	chr20	49212713	49212713	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagacttggaggtgtaccatCagcagcacgtccagctctgg	12	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:49212713C>T	uc002xvm.2	-	15	2184	c.1866G>A	c.(1864-1866)CTG>CTA	p.L622L	FAM65C_uc010zyt.1_Silent_p.L626L|FAM65C_uc010zyu.1_RNA	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	622										ovary(2)	2						GGTGTACCATCAGCAGCACGT	0.597													0	0	0	0.007835	0	41	52										T	49212713	C	T	49212713	2	4	46	1	0	0	0	0	0	0	0	1	5601	813	29	1		1	FAM65C	20	49212713	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	404216	49212713	13812807	1688	13385										
SALL4	57167	broad.mit.edu	37	chr20	50401020	50401020	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acagagatctcattggtcttCacggccagaccgccattgag	10	12	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:50401020C>T	uc002xwh.3	-	4	3047	c.2946G>A	c.(2944-2946)GTG>GTA	p.V982V	SALL4_uc010gii.2_Silent_p.V545V|SALL4_uc002xwi.3_Silent_p.V205V	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	982					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CATTGGTCTTCACGGCCAGAC	0.547													0	0	0	0.007835	0	39	71										T	50401020	C	T	50401020	2	4	46	1	0	0	0	0	0	0	0	1	13813	813	29	1		1	SALL4	20	50401020	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1188307	50401020	12624500	1689	13386										
CYP24A1	1591	broad.mit.edu	37	chr20	52788164	52788164	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acttcccctggtttcattagTttcttttgaaaggcactccg	7	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:52788164T>C	uc002xwv.2	-	3	893	c.495A>G	c.(493-495)AAA>AAG	p.K165K	CYP24A1_uc002xwu.1_Silent_p.K23K|CYP24A1_uc002xww.2_Silent_p.K165K	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	165					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GTTTCATTAGTTTCTTTTGAA	0.498													0	0	0	0.006999	0	40	170										C	52788164	T	C	52788164	2	2	46	1	0	0	0	0	0	0	0	1	4154	1722	60	5		5	CYP24A1	20	52788164	Silent	SNP	T	TCGA-DK-A1AC-01A-11D-A13W-08	2387144	52788164	10237356	1690	13387										
SPO11	23626	broad.mit.edu	37	chr20	55918412	55918412	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacagatggaaataatggcaGactctaaaatgaaggcagaa	11	5	1	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:55918412G>A	uc002xye.2	+	13	1180	c.1087G>A	c.(1087-1089)GAC>AAC	p.D363N	SPO11_uc002xyf.2_Missense_Mutation_p.D325N	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	363					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			AATAATGGCAGACTCTAAAAT	0.323								Editing_and_processing_nucleases					0	0	0	0.01441	0	48	91										A	55918412	G	A	55918412	3	1	46	1	0	0	0	0	1	0	0	0	15076	942	33	1	1137	1	SPO11	20	55918412	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3130248	55918412	7107108	1691	13388										
VAPB	9217	broad.mit.edu	37	chr20	56993382	56993382	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tactgtgtgaggcccaacagCggaatcatcgatgcaggggc	14	10	1	1	rs139149560	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:56993382C>T	uc002xza.2	+	2	445	c.174C>T	c.(172-174)AGC>AGT	p.S58S	VAPB_uc002xzb.2_RNA|VAPB_uc010zzo.1_5'UTR|VAPB_uc002xzc.2_Silent_p.S58S	NM_004738	NP_004729	O95292	VAPB_HUMAN	VAMP-associated protein B/C	58	Cytoplasmic (Potential).|MSP.				cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(1)	1	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			GGCCCAACAGCGGAATCATCG	0.517													0	0	0	0.008871	0	20	112										T	56993382	C	T	56993382	2	4	46	1	0	0	0	0	0	0	0	1	17119	767	27	2		2	VAPB	20	56993382	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1074970	56993382	6032138	1692	13389										
CDH4	1002	broad.mit.edu	37	chr20	60448896	60448896	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagagcccgtcccagaatatGttcaccatcaacagcgagac	8	14	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60448896G>T	uc002ybn.1	+	7	1004	c.990G>T	c.(988-990)ATG>ATT	p.M330I	CDH4_uc002ybp.1_Missense_Mutation_p.M256I	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	330	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCCAGAATATGTTCACCATCA	0.642													1	0	1.64293e-13	0.00333	1.72147e-13	22	85										T	60448896	G	T	60448896	3	4	46	1	0	0	0	0	1	0	0	0	3112	1377	48	4	1016	4	CDH4	20	60448896	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3455514	60448896	2576624	1693	13390										
LAMA5	3911	broad.mit.edu	37	chr20	60893546	60893546	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgctcctggttgcggctgttGagctcctgggcctcccgtgt	14	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60893546G>A	uc002ycq.2	-	53	7270	c.7203C>T	c.(7201-7203)CTC>CTT	p.L2401L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2401	Domain II and I.|Potential.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCGGCTGTTGAGCTCCTGGG	0.672													0	0	0	0.004007	0	11	11										A	60893546	G	A	60893546	2	1	46	1	0	0	0	0	0	0	0	1	8609	1277	45	1		1	LAMA5	20	60893546	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	444650	60893546	2131974	1694	13391										
LAMA5	3911	broad.mit.edu	37	chr20	60908290	60908290	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccagggggaggtgtgtgtaGaggaggcagctggggggaca	22	5	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60908290G>A	uc002ycq.2	-	26	3205	c.3138C>T	c.(3136-3138)CTC>CTT	p.L1046L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1046	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTGTGTAGAGGAGGCAGC	0.716													0	0	0	0.00308	0	8	18										A	60908290	G	A	60908290	2	1	46	1	0	0	0	0	0	0	0	1	8609	929	33	1		1	LAMA5	20	60908290	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14744	60908290	2117230	1695	13392										
LAMA5	3911	broad.mit.edu	37	chr20	60910092	60910092	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcactgcggcagccaaaatAgtcagcctgatccagtccaa	8	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60910092A>G	uc002ycq.2	-	20	2534	c.2467T>C	c.(2467-2469)TAT>CAT	p.Y823H		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	823	Laminin EGF-like 10.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCCAAAATAGTCAGCCTGA	0.652													0	0	0	0.001984	0	6	17										G	60910092	A	G	60910092	3	3	46	1	0	0	0	0	1	0	0	0	8609	420	15	5	8864	5	LAMA5	20	60910092	Missense_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	1802	60910092	2115428	1696	13393										
ARFRP1	10139	broad.mit.edu	37	chr20	62338434	62338434	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttgtacaagcccgacagcaGcgtgtacatcctgccctggg	11	14	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:62338434G>C	uc002yga.2	-	1	577	c.10C>G	c.(10-12)CTG>GTG	p.L4V	ARFRP1_uc002ygc.2_Missense_Mutation_p.L4V|ARFRP1_uc002ygh.3_Missense_Mutation_p.L4V|ARFRP1_uc011abf.1_Missense_Mutation_p.L4V|ARFRP1_uc011abg.1_Missense_Mutation_p.L4V|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.L4V|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	4					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CCCGACAGCAGCGTGTACATC	0.443													0	0	0	0.001984	0	5	7										C	62338434	G	C	62338434	3	2	46	1	0	0	0	0	1	0	0	0	856	962	34	4	627	4	ARFRP1	20	62338434	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1428342	62338434	687086	1697	13394										
ZGPAT	84619	broad.mit.edu	37	chr20	62340319	62340319	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggagaggacgaggaagagctGagtgggacaaaggtgagcgc	20	5	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:62340319G>A	uc002ygk.2	+	2	565	c.387G>A	c.(385-387)CTG>CTA	p.L129L	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Silent_p.L129L|ZGPAT_uc002ygj.2_Silent_p.L129L|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Silent_p.L129L|ZGPAT_uc002ygm.2_Silent_p.L129L|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	129					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					aggaagagCTGAGTGGGACAA	0.537													0	0	0	0.004007	0	17	45										A	62340319	G	A	62340319	2	1	46	1	0	0	0	0	0	0	0	1	17671	1277	45	1		1	ZGPAT	20	62340319	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1885	62340319	685201	1698	13395										
LIPI	149998	broad.mit.edu	37	chr21	15561684	15561684	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tattctcggaataaataaatCtctgaaggaatcctttacac	5	8	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:15561684C>T	uc002yjm.2	-	2	176	c.166G>A	c.(166-168)GAT>AAT	p.D56N	LIPI_uc010gkw.1_5'UTR	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	35					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		ATAAATAAATCTCTGAAGGAA	0.353													0	0	0	0.009718	0	40	153										T	15561684	C	T	15561684	3	4	46	1	0	0	0	0	1	0	0	0	8825	913	32	1	1315	1	LIPI	21	15561684	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		15561684	32568211	1699	13396										
RBM11	54033	broad.mit.edu	37	chr21	15599290	15599290	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatccgtgtcttcctcactGaatcatgttccagatcttga	7	12	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:15599290G>A	uc002yjo.3	+	5	564	c.522G>A	c.(520-522)CTG>CTA	p.L174L	RBM11_uc002yjn.3_Silent_p.L60L|RBM11_uc002yjp.3_Silent_p.L60L	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	174							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTCCTCACTGAATCATGTTC	0.453													0	0	0	0.01441	0	69	273										A	15599290	G	A	15599290	2	1	46	1	0	0	0	0	0	0	0	1	13112	1277	45	1		1	RBM11	21	15599290	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	37606	15599290	32530605	1700	13397										
RBM11	54033	broad.mit.edu	37	chr21	15599416	15599416	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatccgtgtcttcctcactGaatcatgttccagatcttga	7	12	4	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:15599416G>A	uc002yjo.3	+	5	690	c.648G>A	c.(646-648)CTG>CTA	p.L216L	RBM11_uc002yjn.3_Silent_p.L102L|RBM11_uc002yjp.3_Silent_p.L102L	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	216							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTCCTCACTGAATCATGTTC	0.443													0	0	0	0.004482	0	8	395										A	15599416	G	A	15599416	2	1	46	1	0	0	0	0	0	0	0	1	13112	1277	45	1		1	RBM11	21	15599416	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	126	15599416	32530479	1701	13398										
NRIP1	8204	broad.mit.edu	37	chr21	16339706	16339706	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caaatgggcttcgcttgacaGaagtaatgctaactggctac	10	9	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:16339706G>A	uc002yjx.2	-	4	1406	c.808C>T	c.(808-810)CTG>TTG	p.L270L		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	270	LXXLL motif 4.|Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TCGCTTGACAGAAGTAATGCT	0.463													0	0	0	0.01441	0	68	122										A	16339706	G	A	16339706	2	1	46	1	0	0	0	0	0	0	0	1	10652	933	33	1		1	NRIP1	21	16339706	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	740290	16339706	31790189	1702	13399										
APP	351	broad.mit.edu	37	chr21	27326925	27326925	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aacttcatcctgaatctcctCggccactgcaggcacgttgt	8	14	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:27326925C>T	uc002ylz.2	-	13	1866	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K	APP_uc011acg.1_Missense_Mutation_p.E64K|APP_uc010glk.2_Missense_Mutation_p.E532K|APP_uc002yma.2_Missense_Mutation_p.E537K|APP_uc011ach.1_Missense_Mutation_p.E500K|APP_uc002ymb.2_Missense_Mutation_p.E481K|APP_uc010glj.2_Missense_Mutation_p.E425K|APP_uc011aci.1_Missense_Mutation_p.E446K	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	556	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TGAATCTCCTCGGCCACTGCA	0.463													0	0	0	0.010729	0	12	25										T	27326925	C	T	27326925	3	4	46	1	0	0	0	0	1	0	0	0	815	893	31	1	670	1	APP	21	27326925	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	10987219	27326925	20802970	1703	13400										
APP	351	broad.mit.edu	37	chr21	27423431	27423431	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtgggcaacacacaaactCtacccctcggaacttgtcaa	7	14	2	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:27423431C>G	uc002ylz.2	-	5	747	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	APP_uc010glk.2_Missense_Mutation_p.E178Q|APP_uc002yma.2_Missense_Mutation_p.E183Q|APP_uc011ach.1_Missense_Mutation_p.E127Q|APP_uc002ymb.2_Missense_Mutation_p.E183Q|APP_uc010glj.2_Missense_Mutation_p.E127Q|APP_uc011aci.1_Missense_Mutation_p.E148Q|APP_uc011acj.1_Missense_Mutation_p.E183Q	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	183	Extracellular (Potential).|Zinc-binding.				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				CACACAAACTCTACCCCTCGG	0.512													0	0	0	0.001168	0	6	54										G	27423431	C	G	27423431	3	3	46	1	0	0	0	0	1	0	0	0	815	922	32	1	1821	1	APP	21	27423431	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	96506	27423431	20706464	1704	13401										
GRIK1	2897	broad.mit.edu	37	chr21	30949385	30949385	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tatgggggattccattctctCtactgtcaagaaggcagcca	10	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:30949385C>G	uc002yno.1	-	14	2493	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	GRIK1_uc002ynn.2_Missense_Mutation_p.E662Q|GRIK1_uc011acs.1_Missense_Mutation_p.E677Q|GRIK1_uc011act.1_Missense_Mutation_p.E538Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	677	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCCATTCTCTCTACTGTCAAG	0.448													0	0	0	0.00278	0	24	105										G	30949385	C	G	30949385	3	3	46	1	0	0	0	0	1	0	0	0	6773	922	32	1	903	1	GRIK1	21	30949385	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	3525954	30949385	17180510	1705	13402										
DNAJC28	54943	broad.mit.edu	37	chr21	34860800	34860800	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taattttctgatgttttcttGaaactgctcacaaacatggt	6	7	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:34860800G>C	uc002yrv.2	-	2	1350	c.901C>G	c.(901-903)CAA>GAA	p.Q301E	DNAJC28_uc002yrw.2_Missense_Mutation_p.Q301E	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	301	Potential.						heat shock protein binding				0						ATGTTTTCTTGAAACTGCTCA	0.353													0	0	0	0.01441	0	103	125										C	34860800	G	C	34860800	3	2	46	1	0	0	0	0	1	0	0	0	4646	1299	45	1	269	1	DNAJC28	21	34860800	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3911415	34860800	13269095	1706	13403										
RCAN1	1827	broad.mit.edu	37	chr21	35895867	35895867	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taacttcatttcctttcccaGaaactcagtcttatgcagct	4	12	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:35895867G>C	uc002yue.2	-	2	466	c.394C>G	c.(394-396)CTG>GTG	p.L132V	RCAN1_uc002yuc.2_Missense_Mutation_p.L51V|RCAN1_uc002yud.2_5'UTR|RCAN1_uc002yub.2_Missense_Mutation_p.L77V|RCAN1_uc011adx.1_Missense_Mutation_p.L77V	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	132					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TCCTTTCCCAGAAACTCAGTC	0.453													0	0	0	0.010818	0	32	53										C	35895867	G	C	35895867	3	2	46	1	0	0	0	0	1	0	0	0	13168	933	33	1	376	1	RCAN1	21	35895867	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1035067	35895867	12234028	1707	13404										
RCAN1	1827	broad.mit.edu	37	chr21	35895991	35895991	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tccttgtcatacgtcctaaaGagggactcaaatttggcctg	9	10	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:35895991G>C	uc002yue.2	-	2	342	c.270C>G	c.(268-270)CTC>CTG	p.L90L	RCAN1_uc002yuc.2_Silent_p.L9L|RCAN1_uc002yud.2_5'UTR|RCAN1_uc002yub.2_Silent_p.L35L|RCAN1_uc011adx.1_Silent_p.L35L	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	90					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						ACGTCCTAAAGAGGGACTCAA	0.378													0	0	0	0.008361	0	30	59										C	35895991	G	C	35895991	2	2	46	1	0	0	0	0	0	0	0	1	13168	929	33	1		1	RCAN1	21	35895991	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	124	35895991	12233904	1708	13405										
RUNX1	861	broad.mit.edu	37	chr21	36252962	36252962	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtagttttcatcattgccagCcatcacagtgaccagagtgc	9	11	3	2	rs74315451		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:36252962C>G	uc002yuh.2	-	2	1897	c.319G>C	c.(319-321)GCT>CCT	p.A107P	RUNX1_uc002yui.2_Missense_Mutation_p.A107P|RUNX1_uc010gmu.2_Missense_Mutation_p.A134P|RUNX1_uc010gmv.2_Missense_Mutation_p.A134P|RUNX1_uc002yuj.3_Missense_Mutation_p.A2P|RUNX1_uc002yuk.3_Missense_Mutation_p.A134P|RUNX1_uc002yum.1_Missense_Mutation_p.A2P|RUNX1_uc010gmw.1_Missense_Mutation_p.A134P|RUNX1_uc002yuo.1_Missense_Mutation_p.A107P|RUNX1_uc002yur.1_Missense_Mutation_p.A2P	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	107	Runt.			A->T: Loss of heterodimerization.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.R107C(12)|p.R107H(2)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TCATTGCCAGCCATCACAGTG	0.488			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				0	0	0	0.007413	0	19	20										G	36252962	C	G	36252962	3	3	46	1	0	0	0	0	1	0	0	0	13746	739	26	4	1095	4	RUNX1	21	36252962	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	356971	36252962	11876933	1709	13406										
DOPEY2	9980	broad.mit.edu	37	chr21	37642413	37642413	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggaagtgaaggcccaacctCaggcctctctagaagaatct	10	11	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:37642413C>T	uc002yvg.2	+	27	5669	c.5590C>T	c.(5590-5592)CAG>TAG	p.Q1864*	DOPEY2_uc011aeb.1_Nonsense_Mutation_p.Q1813*	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1864					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GGCCCAACCTCAGGCCTCTCT	0.527													0	0	0	0.01441	0	61	62										T	37642413	C	T	37642413	4	4	46	1	0	0	0	0	0	1	0	0	4708	827	29	1	5692	1	DOPEY2	21	37642413	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1389451	37642413	10487482	1710	13407										
ETS2	2114	broad.mit.edu	37	chr21	40191551	40191551	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caacgggttccttccttcgaGagcttcgaagatgactgcag	11	11	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:40191551G>A	uc002yxg.2	+	8	1132	c.936G>A	c.(934-936)GAG>GAA	p.E312E	ETS2_uc002yxf.2_Silent_p.E452E	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	312					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CTTCCTTCGAGAGCTTCGAAG	0.547													0	0	0	0.001984	0	7	20										A	40191551	G	A	40191551	2	1	46	1	0	0	0	0	0	0	0	1	5276	933	33	1		1	ETS2	21	40191551	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2549138	40191551	7938344	1711	13408										
MX2	4600	broad.mit.edu	37	chr21	42778893	42778893	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcggtttcctcctttactGaaataggcatccacctgaat	6	12	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:42778893G>A	uc002yzf.1	+	13	1977	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	MX2_uc002yzg.1_Missense_Mutation_p.E348K|MX2_uc010gop.1_Missense_Mutation_p.E107K	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	625	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CTCCTTTACTGAAATAGGCAT	0.488													0	0	0	0.010771	0	41	41										A	42778893	G	A	42778893	3	1	46	1	0	0	0	0	1	0	0	0	9998	1291	45	1	1919	1	MX2	21	42778893	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2587342	42778893	5351002	1712	13409										
MX1	4599	broad.mit.edu	37	chr21	42821118	42821118	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgaaaatcagtatcgtggtaGagagctgccaggctttgtga	13	6	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:42821118G>A	uc002yzh.2	+	16	2275	c.1328G>A	c.(1327-1329)AGA>AAA	p.R443K	MX1_uc002yzi.2_Missense_Mutation_p.R443K|MX1_uc010goq.2_Missense_Mutation_p.R443K	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	443					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				TATCGTGGTAGAGAGCTGCCA	0.383													0	0	0	0.012319	0	20	81										A	42821118	G	A	42821118	3	1	46	1	0	0	0	0	1	0	0	0	9997	942	33	1	1366	1	MX1	21	42821118	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	42225	42821118	5308777	1713	13410										
UBASH3A	53347	broad.mit.edu	37	chr21	43867289	43867289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatttaactggaggaactgGatctcaggcaactgagagcc	12	9	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:43867289G>C	uc002zbe.2	+	15	2007	c.1971G>C	c.(1969-1971)TGG>TGC	p.W657C	UBASH3A_uc002zbf.2_Missense_Mutation_p.W619C|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_3'UTR	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	657	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						GGAGGAACTGGATCTCAGGCA	0.527													0	0	0	0.004289	0	38	107										C	43867289	G	C	43867289	3	2	46	1	0	0	0	0	1	0	0	0	16836	1183	41	1	2029	1	UBASH3A	21	43867289	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1046171	43867289	4262606	1714	13411										
UBASH3A	53347	broad.mit.edu	37	chr21	43867303	43867303	+	Nonstop_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaactggatctcaggcaactGagagccacggtgatgttgtc	13	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:43867303G>T	uc002zbe.2	+	15	2021	c.1985G>T	c.(1984-1986)TGA>TTA	p.*662L	UBASH3A_uc002zbf.2_Nonstop_Mutation_p.*624L|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_3'UTR	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	662						cytosol|nucleus				ovary(3)	3						TCAGGCAACTGAGAGCCACGG	0.542													1	0	6.00712e-18	0.012213	6.34329e-18	34	98										T	43867303	G	T	43867303	4	4	46	1	0	0	0	0	0	0	0	0	16836	1285	45	3	2043	3	UBASH3A	21	43867303	Nonstop_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	14	43867303	4262592	1715	13412										
TRAPPC10	7109	broad.mit.edu	37	chr21	45503018	45503018	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tctgataactccttgaacacGactgggattatctgcagaaa	8	9	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45503018G>C	uc002zea.2	+	14	2242	c.2073G>C	c.(2071-2073)ACG>ACC	p.T691T	TRAPPC10_uc010gpo.2_Silent_p.T402T|TRAPPC10_uc011afa.1_Silent_p.T110T	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	691					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCTTGAACACGACTGGGATTA	0.547													0	0	0	0.00333	0	26	72										C	45503018	G	C	45503018	2	2	46	1	0	0	0	0	0	0	0	1	16454	1045	37	1		1	TRAPPC10	21	45503018	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1635715	45503018	2626877	1716	13413			3	48		3	3	75	N	G_C	8.79585e-06
TRAPPC10	7109	broad.mit.edu	37	chr21	45503079	45503079	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ggcaggagagcagctcctctCtagagatgccctcaggggtg	15	11	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45503079C>T	uc002zea.2	+	14	2303	c.2134C>T	c.(2134-2136)CTA>TTA	p.L712L	TRAPPC10_uc010gpo.2_Silent_p.L423L|TRAPPC10_uc011afa.1_Silent_p.L131L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	712					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAGCTCCTCTCTAGAGATGCC	0.557													0	0	0	0.01441	0	72	80										T	45503079	C	T	45503079	2	4	46	1	0	0	0	0	0	0	0	1	16454	912	32	1		1	TRAPPC10	21	45503079	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	61	45503079	2626816	1717	13414			3	48		3	3	75	N	G_C	8.79585e-06
TRAPPC10	7109	broad.mit.edu	37	chr21	45503092	45503092	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcctctctagagatgccctCaggggtggctctggaggagg	15	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45503092C>T	uc002zea.2	+	14	2316	c.2147C>T	c.(2146-2148)TCA>TTA	p.S716L	TRAPPC10_uc010gpo.2_Missense_Mutation_p.S427L|TRAPPC10_uc011afa.1_Missense_Mutation_p.S135L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	716					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						GAGATGCCCTCAGGGGTGGCT	0.567													0	0	0	0.01441	0	79	91										T	45503092	C	T	45503092	3	4	46	1	0	0	0	0	1	0	0	0	16454	838	29	1	2201	1	TRAPPC10	21	45503092	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	13	45503092	2626803	1718	13415			3	48		3	3	75	N	G_C	8.79585e-06
TRPM2	7226	broad.mit.edu	37	chr21	45789113	45789113	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcgtcatgaagcaggtaggcGaggcggtgcgggacttcagc	18	9	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45789113G>A	uc002zet.1	+	6	871	c.658G>A	c.(658-660)GAG>AAG	p.E220K	TRPM2_uc002zeu.1_Missense_Mutation_p.E220K|TRPM2_uc002zew.1_Missense_Mutation_p.E220K|TRPM2_uc010gpt.1_Missense_Mutation_p.E220K|TRPM2_uc002zex.1_Missense_Mutation_p.E6K	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	220	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAGGTAGGCGAGGCGGTGCG	0.682													0	0	0	0.001168	0	5	9										A	45789113	G	A	45789113	3	1	46	1	0	0	0	0	1	0	0	0	16583	1059	37	1	676	1	TRPM2	21	45789113	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	286021	45789113	2340782	1719	13416										
CCT8L2	150160	broad.mit.edu	37	chr22	17072537	17072537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtccgccagtgtgagggtctCctcgtcgacctcccccaaca	10	17	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:17072537C>T	uc002zlp.1	-	1	1164	c.904G>A	c.(904-906)GAG>AAG	p.E302K		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	302					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTGAGGGTCTCCTCGTCGACC	0.493													0	0	0	0.007835	0	36	88										T	17072537	C	T	17072537	3	4	46	1	0	0	0	0	1	0	0	0	2961	864	30	1	773	1	CCT8L2	22	17072537	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		17072537	34232029	1720	13417										
PEX26	55670	broad.mit.edu	37	chr22	18566437	18566437	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcaggccattcacacagcGaggcagcagcagaaacagga	11	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:18566437G>A	uc002znp.3	+	4	815	c.606G>A	c.(604-606)GCG>GCA	p.A202A	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Silent_p.A202A|PEX26_uc002znt.2_Silent_p.A202A	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	202	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						TTCACACAGCGAGGCAGCAGC	0.572													0	0	0	0.006122	0	15	24										A	18566437	G	A	18566437	2	1	46	1	0	0	0	0	0	0	0	1	11746	1045	37	1		1	PEX26	22	18566437	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1493900	18566437	32738129	1721	13418										
HIRA	7290	broad.mit.edu	37	chr22	19418988	19418988	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggttgacccaggtcggcttCaggagcttcattgttcggcc	13	11	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:19418988C>T	uc002zpf.1	-	1	232	c.12G>A	c.(10-12)CTG>CTA	p.L4L	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Silent_p.L4L|HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zpg.2_5'Flank|MRPL40_uc002zph.2_5'Flank	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	4					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					AGGTCGGCTTCAGGAGCTTCA	0.557													0	0	0	0.00308	0	7	12										T	19418988	C	T	19418988	2	4	46	1	0	0	0	0	0	0	0	1	7120	813	29	1		1	HIRA	22	19418988	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	852551	19418988	31885578	1722	13419										
SERPIND1	3053	broad.mit.edu	37	chr22	21141329	21141329	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcctgctcttcatgggaaGagtggccaaccccagcaggt	12	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:21141329G>A	uc002ztb.1	+	5	1542	c.1475G>A	c.(1474-1476)AGA>AAA	p.R492K	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.R520K	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	492					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TTCATGGGAAGAGTGGCCAAC	0.562													0	0	0	0.004482	0	7	37										A	21141329	G	A	21141329	3	1	46	1	0	0	0	0	1	0	0	0	14110	942	33	1	1489	1	SERPIND1	22	21141329	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1722341	21141329	30163237	1723	13420										
SMARCB1	6598	broad.mit.edu	37	chr22	24159103	24159103	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcatcctggaggaccagtcaGaccagcgcgtcatcatcaag	11	13	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:24159103G>A	uc002zyb.2	+	6	982	c.775G>A	c.(775-777)GAC>AAC	p.D259N	SMARCB1_uc002zya.2_Intron|SMARCB1_uc002zyc.2_Missense_Mutation_p.D250N|SMARCB1_uc002zyd.2_Missense_Mutation_p.D268N	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	259	2.|2 X approximate tandem repeats.				cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(3)|p.D259fs*26(1)|p.E210fs*15(1)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				GGACCAGTCAGACCAGCGCGT	0.582			D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				0	0	0	0.013537	0	11	40										A	24159103	G	A	24159103	3	1	46	1	0	0	0	0	1	0	0	0	14774	942	33	1	797	1	SMARCB1	22	24159103	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3017774	24159103	27145463	1724	13421										
UPB1	51733	broad.mit.edu	37	chr22	24917979	24917979	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cttcccgaacgagtttacctCgggagatggaaagaaaggta	12	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:24917979C>T	uc003aaf.2	+	8	1020	c.899C>T	c.(898-900)TCG>TTG	p.S300L	UPB1_uc003aae.2_Missense_Mutation_p.S232L|UPB1_uc011ajt.1_Missense_Mutation_p.S300L	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	300	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					GAGTTTACCTCGGGAGATGGA	0.522											OREG0026411	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	21										T	24917979	C	T	24917979	3	4	46	1	0	0	0	0	1	0	0	0	16999	893	31	1	929	1	UPB1	22	24917979	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	758876	24917979	26386587	1725	13422										
LRP5L	91355	broad.mit.edu	37	chr22	25747768	25747768	+	Nonstop_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgcaggtcttcatgtcactcAgcagttccaggccctagatg	10	12	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:25747768A>T	uc003abs.2	-	4	3222	c.757T>A	c.(757-759)TGA>AGA	p.*253R	LRP5L_uc011ajz.1_Nonstop_Mutation_p.*253R|LRP5L_uc010guw.1_Silent_p.A223A	NM_182492	NP_872298	A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein	253											0						CATGTCACTCAGCAGTTCCAG	0.577													0	0	0	0.008871	0	18	49										T	25747768	A	T	25747768	4	4	46	1	0	0	0	0	0	0	0	0	8961	201	7	5	5	5	LRP5L	22	25747768	Nonstop_Mutation	SNP	A	TCGA-DK-A1AC-01A-11D-A13W-08	829789	25747768	25556798	1726	13423										
NEFH	4744	broad.mit.edu	37	chr22	29886470	29886470	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccagcaaaccagcagagaaGaaggaggcagcaccggagaa	13	11	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:29886470G>C	uc003afo.2	+	4	2912	c.2841G>C	c.(2839-2841)AAG>AAC	p.K947N	NEFH_uc003afp.2_Missense_Mutation_p.R13T	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	953	Tail.				cell death|nervous system development	neurofilament					0						CAGCAGAGAAGAAGGAGGCAG	0.512													0	0	0	0.00245	0	15	31										C	29886470	G	C	29886470	3	2	46	1	0	0	0	0	1	0	0	0	10314	933	33	1	2855	1	NEFH	22	29886470	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	4138702	29886470	21418096	1727	13424										
ASCC2	84164	broad.mit.edu	37	chr22	30198101	30198101	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gcaggccaggatgaagccctCaccaaggtctggcagcaggt	14	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:30198101C>T	uc003agr.2	-	14	1555	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	ASCC2_uc003ags.2_Intron|ASCC2_uc003agt.2_Missense_Mutation_p.E484K|ASCC2_uc011akr.1_Missense_Mutation_p.E408K	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	484	CUE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			ATGAAGCCCTCACCAAGGTCT	0.617													0	0	0	0.001984	0	5	33										T	30198101	C	T	30198101	3	4	46	1	0	0	0	0	1	0	0	0	1032	835	29	1	851	1	ASCC2	22	30198101	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	311631	30198101	21106465	1728	13425										
MTP18	51537	broad.mit.edu	37	chr22	30822716	30822716	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctcccccaggctatgccaatGaggtgggcgaggctttccgc	13	14	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:30822716G>A	uc003ahw.1	+	2	227	c.79G>A	c.(79-81)GAG>AAG	p.E27K	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Missense_Mutation_p.E189K|MTP18_uc010gvy.1_Intron|MTP18_uc003ahx.1_Missense_Mutation_p.E27K	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	27					apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						CTATGCCAATGAGGTGGGCGA	0.478											OREG0026460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	7	19										A	30822716	G	A	30822716	3	1	46	1	0	0	0	0	1	0	0	0	9955	1291	45	1	85	1	MTP18	22	30822716	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	624615	30822716	20481850	1729	13426										
PATZ1	23598	broad.mit.edu	37	chr22	31738885	31738885	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccctgacccagcccctacctGacacttgtgaggccgctcag	9	18	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:31738885G>A	uc003akq.2	-	2	1994	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*	PATZ1_uc003akp.2_Nonsense_Mutation_p.Q445*|PATZ1_uc003akr.2_Nonsense_Mutation_p.Q445*|PATZ1_uc003aks.2_Nonsense_Mutation_p.Q445*	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	445	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						GCCCCTACCTGACACTTGTGA	0.582													0	0	0	0.004656	0	23	89										A	31738885	G	A	31738885	4	1	46	1	0	0	0	0	0	1	0	0	11476	1299	45	1	1029	1	PATZ1	22	31738885	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	916169	31738885	19565681	1730	13427										
SLC5A1	6523	broad.mit.edu	37	chr22	32495203	32495203	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtgctgattggcatcagcatCgcctgggtgcccattgtgca	13	11	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:32495203C>T	uc003amc.2	+	12	1546	c.1314C>T	c.(1312-1314)ATC>ATT	p.I438I	SLC5A1_uc011alz.1_Silent_p.I311I	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	438	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						GCATCAGCATCGCCTGGGTGC	0.453													0	0	0	0.011902	0	47	127										T	32495203	C	T	32495203	2	4	46	1	0	0	0	0	0	0	0	1	14661	874	31	1		1	SLC5A1	22	32495203	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	756318	32495203	18809363	1731	13428										
APOL5	80831	broad.mit.edu	37	chr22	36122285	36122285	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgtgaacctgtgccagagttGgaaaattaacaatttgatgt	10	6	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:36122285G>A	uc003aof.2	+	3	170	c.170G>A	c.(169-171)TGG>TAG	p.W57*		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	57					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						TGCCAGAGTTGGAAAATTAAC	0.453													0	0	0	0.00245	0	14	54										A	36122285	G	A	36122285	4	1	46	1	0	0	0	0	0	1	0	0	809	1357	47	2	180	2	APOL5	22	36122285	Nonsense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3627082	36122285	15182281	1732	13429										
APOL5	80831	broad.mit.edu	37	chr22	36122301	36122301	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agttggaaaattaacaatttGatgtcaactgtccacagtga	8	6	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:36122301G>A	uc003aof.2	+	3	186	c.186G>A	c.(184-186)TTG>TTA	p.L62L		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	62					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						TTAACAATTTGATGTCAACTG	0.458													0	0	0	0.012213	0	30	34										A	36122301	G	A	36122301	2	1	46	1	0	0	0	0	0	0	0	1	809	1281	45	1		1	APOL5	22	36122301	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	16	36122301	15182265	1733	13430										
MYH9	4627	broad.mit.edu	37	chr22	36690984	36690984	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggaggctccgcacccgcttCgtctgctccagctgctccgc	12	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:36690984C>T	uc003apg.2	-	27	3855	c.3624G>A	c.(3622-3624)ACG>ACA	p.T1208T		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1208	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCACCCGCTTCGTCTGCTCCA	0.587			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.013726	0	31	74										T	36690984	C	T	36690984	2	4	46	1	0	0	0	0	0	0	0	1	10042	871	31	1		1	MYH9	22	36690984	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	568683	36690984	14613582	1734	13431										
NCF4	4689	broad.mit.edu	37	chr22	37268449	37268449	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atcttcctcctcagtcggatCaacaaagactggctggaggt	10	11	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:37268449C>G	uc003apy.3	+	7	793	c.609C>G	c.(607-609)ATC>ATG	p.I203M	NCF4_uc003apz.3_Missense_Mutation_p.I203M	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	203	SH3.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						TCAGTCGGATCAACAAAGACT	0.254													0	0	0	0.005443	0	26	62										G	37268449	C	G	37268449	3	3	46	1	0	0	0	0	1	0	0	0	10218	816	29	1	635	1	NCF4	22	37268449	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	577465	37268449	14036117	1735	13432										
CSF2RB	1439	broad.mit.edu	37	chr22	37331726	37331726	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccagcaagagccacctgttCcaggtaggaactggctgcga	12	13	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:37331726C>T	uc003aqa.3	+	12	1678	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F	CSF2RB_uc003aqc.3_Silent_p.F493F	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	487	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GCCACCTGTTCCAGGTAGGAA	0.612													0	0	0	0.000602	0	5	14										T	37331726	C	T	37331726	2	4	46	1	0	0	0	0	0	0	0	1	3935	854	30	1		1	CSF2RB	22	37331726	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	63277	37331726	13972840	1736	13433										
CYTH4	27128	broad.mit.edu	37	chr22	37688736	37688736	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accgaaagcagctcctggagGacatccaggtgagtgcacac	12	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:37688736G>A	uc003arf.2	+	2	210	c.94G>A	c.(94-96)GAC>AAC	p.D32N	CYTH4_uc003ard.3_Missense_Mutation_p.D32N|CYTH4_uc003are.2_Missense_Mutation_p.D32N|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	32	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GCTCCTGGAGGACATCCAGGT	0.617													0	0	0	0.014323	0	23	22										A	37688736	G	A	37688736	3	1	46	1	0	0	0	0	1	0	0	0	4206	1174	41	1	100	1	CYTH4	22	37688736	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	357010	37688736	13615830	1737	13434										
PDGFB	5155	broad.mit.edu	37	chr22	39629484	39629484	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agctctccagctcgcctccaGagtgggagcgggtcatgttc	13	13	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:39629484G>C	uc003axf.2	-	3	1195	c.206C>G	c.(205-207)TCT>TGT	p.S69C	PDGFB_uc003axe.2_Missense_Mutation_p.S54C	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	69					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	CTCGCCTCCAGAGTGGGAGCG	0.607			T	COL1A1	DFSP								0	0	0	0.006214	0	10	34										C	39629484	G	C	39629484	3	2	46	1	0	0	0	0	1	0	0	0	11658	942	33	1	535	1	PDGFB	22	39629484	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1940748	39629484	11675082	1738	13435										
PDGFB	5155	broad.mit.edu	37	chr22	39639936	39639936	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accagacgcaggtagcagcaGagagacaggaagagcgccca	14	11	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:39639936G>A	uc003axf.2	-	1	1022	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	11					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	GGTAGCAGCAGAGAGACAGGA	0.582			T	COL1A1	DFSP								0	0	0	0.004672	0	3	8										A	39639936	G	A	39639936	2	1	46	1	0	0	0	0	0	0	0	1	11658	929	33	1		1	PDGFB	22	39639936	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	10452	39639936	11664630	1739	13436										
CACNA1I	8911	broad.mit.edu	37	chr22	40061947	40061947	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgcaacatcaccaaccgctCggactgcatggccgccaact	8	18	1	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40061947C>T	uc003ayc.2	+	23	4040	c.4040C>T	c.(4039-4041)TCG>TTG	p.S1347L	CACNA1I_uc003ayd.2_Missense_Mutation_p.S1312L|CACNA1I_uc003aye.2_Missense_Mutation_p.S1262L|CACNA1I_uc003ayf.2_Missense_Mutation_p.S1227L	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1347	Extracellular (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACCAACCGCTCGGACTGCATG	0.597													0	0	0	0.004482	0	8	23										T	40061947	C	T	40061947	3	4	46	1	0	0	0	0	1	0	0	0	2546	893	31	1	4130	1	CACNA1I	22	40061947	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	422011	40061947	11242619	1740	13437										
CACNA1I	8911	broad.mit.edu	37	chr22	40078519	40078519	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agggtgagctggacccacctGagcccatgcgtgtgggagac	16	11	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40078519G>A	uc003ayc.2	+	35	5683	c.5683G>A	c.(5683-5685)GAG>AAG	p.E1895K	CACNA1I_uc003ayd.2_Missense_Mutation_p.E1860K|CACNA1I_uc003aye.2_Missense_Mutation_p.E1810K|CACNA1I_uc003ayf.2_Missense_Mutation_p.E1775K	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1895	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGACCCACCTGAGCCCATGCG	0.607													0	0	0	0.007291	0	23	50										A	40078519	G	A	40078519	3	1	46	1	0	0	0	0	1	0	0	0	2546	1291	45	1	5821	1	CACNA1I	22	40078519	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	16572	40078519	11226047	1741	13438										
GRAP2	9402	broad.mit.edu	37	chr22	40343156	40343156	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcactgcttcaggtgaggatGaactgagctttcacactgga	11	9	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40343156G>A	uc003ayh.1	+	2	309	c.46G>A	c.(46-48)GAA>AAA	p.E16K	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Intron|GRAP2_uc011aon.1_Intron|GRAP2_uc010gya.1_Missense_Mutation_p.E16K|GRAP2_uc011aoo.1_5'UTR|GRAP2_uc011aop.1_Missense_Mutation_p.E16K|GRAP2_uc011aoq.1_Intron|GRAP2_uc003ayj.1_Missense_Mutation_p.E16K	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	16	SH3 1.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGGTGAGGATGAACTGAGCTT	0.498													0	0	0	0.010504	0	20	48										A	40343156	G	A	40343156	3	1	46	1	0	0	0	0	1	0	0	0	6754	1291	45	1	48	1	GRAP2	22	40343156	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	264637	40343156	10961410	1742	13439										
TNRC6B	23112	broad.mit.edu	37	chr22	40662285	40662285	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtctggatggggggagctctCagcctctacagagtggaaag	16	8	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40662285C>G	uc011aor.1	+	5	2262	c.2051C>G	c.(2050-2052)TCA>TGA	p.S684*	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.S684*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.S488*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	684					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GGGGAGCTCTCAGCCTCTACA	0.552													0	0	0	0.004672	0	3	4										G	40662285	C	G	40662285	4	3	46	1	0	0	0	0	0	1	0	0	16338	838	29	1	2190	1	TNRC6B	22	40662285	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	319129	40662285	10642281	1743	13440										
SGSM3	27352	broad.mit.edu	37	chr22	40805700	40805700	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttgcaggcgcagcagcccctGaaggagggcgtccgggacat	16	12	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40805700G>A	uc003ayu.1	+	22	2396	c.2187G>A	c.(2185-2187)CTG>CTA	p.L729L	SGSM3_uc011aot.1_Silent_p.L640L|SGSM3_uc010gyd.1_Silent_p.L800L	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	729					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						AGCAGCCCCTGAAGGAGGGCG	0.662													0	0	0	0.010504	0	16	38										A	40805700	G	A	40805700	2	1	46	1	0	0	0	0	0	0	0	1	14224	1277	45	1		1	SGSM3	22	40805700	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	143415	40805700	10498866	1744	13441										
PKDREJ	10343	broad.mit.edu	37	chr22	46654093	46654093	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttagaatgtaactcagaaaCaggagtgctcttctcttgat	9	7	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:46654093C>G	uc003bhh.2	-	1	5127	c.5127G>C	c.(5125-5127)CTG>CTC	p.L1709L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1709	Helical; (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACTCAGAAACAGGAGTGCTC	0.403													0	0	0	0.006214	0	9	89										G	46654093	C	G	46654093	2	3	46	1	0	0	0	0	0	0	0	1	11970	465	17	4		4	PKDREJ	22	46654093	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	5848393	46654093	4650473	1745	13442										
TRABD	80305	broad.mit.edu	37	chr22	50635718	50635718	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tgctgctgctgaaggtgtctGcacacatcaccgagcagctg	12	12	2	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:50635718G>A	uc003bjq.1	+	6	555	c.469G>A	c.(469-471)GCA>ACA	p.A157T	TRABD_uc003bjr.1_Missense_Mutation_p.A41T|TRABD_uc003bjs.1_Missense_Mutation_p.A157T|TRABD_uc003bjt.1_Missense_Mutation_p.A157T|TRABD_uc003bju.1_Missense_Mutation_p.A157T|TRABD_uc003bjv.2_Missense_Mutation_p.A157T|TRABD_uc003bjw.1_Missense_Mutation_p.A157T	NM_025204	NP_079480	Q9H4I3	TRABD_HUMAN	TraB domain containing	157											0		all_cancers(38;1.07e-07)|all_epithelial(38;9.6e-07)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		LUAD - Lung adenocarcinoma(64;0.105)		GAAGGTGTCTGCACACATCAC	0.662													0	0	0	0.008291	0	11	37										A	50635718	G	A	50635718	3	1	46	1	0	0	0	0	1	0	0	0	16432	1319	46	2	487	2	TRABD	22	50635718	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3981625	50635718	668848	1746	13443										
IL3RA	3563	broad.mit.edu	37	chrX	1484114	1484114	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cgggaaagagtgtatgaattCttgagcgcctggagcacccc	13	10	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:1484114C>G	uc004cps.2	+	9	1192	c.843C>G	c.(841-843)TTC>TTG	p.F281L	IL3RA_uc011mhd.1_Missense_Mutation_p.F203L	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	281	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGTATGAATTCTTGAGCGCCT	0.413													0	0	0	0.008871	0	18	30										G	1484114	C	G	1484114	3	3	46	1	0	0	0	0	1	0	0	0	7695	912	32	1	873	1	IL3RA	23	1484114	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08		1484114	153786446	1747	13444										
WWC3	55841	broad.mit.edu	37	chrX	10104698	10104698	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgtagtgacagcgacagttCaacgctgccccggaagtccc	11	14	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:10104698C>T	uc004csx.3	+	20	2987	c.2789C>T	c.(2788-2790)TCA>TTA	p.S930L	WWC3_uc010nds.2_Missense_Mutation_p.S594L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	930										ovary(4)	4						AGCGACAGTTCAACGCTGCCC	0.443													0	0	0	0.001855	0	13	32										T	10104698	C	T	10104698	3	4	46	1	0	0	0	0	1	0	0	0	17410	838	29	1	2863	1	WWC3	23	10104698	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	8620584	10104698	145165862	1748	13445										
HCCS	3052	broad.mit.edu	37	chrX	11130276	11130276	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccgatgcatgaagggaaaatGaaaggtaatcggccctttgc	12	8	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:11130276G>A	uc004cuk.2	+	2	362	c.96G>A	c.(94-96)ATG>ATA	p.M32I	uc004cui.1_5'Flank|HCCS_uc004cuj.2_Missense_Mutation_p.M32I|HCCS_uc004cul.1_Missense_Mutation_p.M32I	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	32					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						AAGGGAAAATGAAAGGTAATC	0.353													0	0	0	0.001855	0	13	22										A	11130276	G	A	11130276	3	1	46	1	0	0	0	0	1	0	0	0	6990	1290	45	1	98	1	HCCS	23	11130276	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1025578	11130276	144140284	1749	13446										
TLR7	51284	broad.mit.edu	37	chrX	12906158	12906158	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gactaacctgattctgttctCactttccatatctgtatctc	4	12	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:12906158C>A	uc004cvc.2	+	3	2670	c.2531C>A	c.(2530-2532)TCA>TAA	p.S844*		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	844	Helical; (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATTCTGTTCTCACTTTCCATA	0.453													1	0	6.73184e-63	0.01441	7.16434e-63	144	34										A	12906158	C	A	12906158	4	1	46	1	0	0	0	0	0	1	0	0	15953	838	29	3	2537	3	TLR7	23	12906158	Nonsense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1775882	12906158	142364402	1750	13447										
ZRSR2	8233	broad.mit.edu	37	chrX	15809081	15809081	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaaaagtacagggccgccctGaagaaggagaaacgaaagaa	12	7	0	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:15809081G>A	uc004cxg.3	+	2	111	c.66G>A	c.(64-66)CTG>CTA	p.L22L		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	22					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					GGGCCGCCCTGAAGAAGGAGA	0.512													0	0	0	0.004007	0	15	4										A	15809081	G	A	15809081	2	1	46	1	0	0	0	0	0	0	0	1	18222	1277	45	1		1	ZRSR2	23	15809081	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2902923	15809081	139461479	1751	13448										
GPR64	10149	broad.mit.edu	37	chrX	19032082	19032082	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagcaaaagaggtagctttgGggacctgggaaagcacagtg	15	7	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:19032082G>C	uc004cyx.2	-	16	985	c.821C>G	c.(820-822)CCC>CGC	p.P274R	GPR64_uc004cyy.2_Missense_Mutation_p.P271R|GPR64_uc004cyz.2_Missense_Mutation_p.P260R|GPR64_uc004czb.2_Missense_Mutation_p.P274R|GPR64_uc004czc.2_Missense_Mutation_p.P258R|GPR64_uc004czd.2_Missense_Mutation_p.P250R|GPR64_uc004cze.2_Missense_Mutation_p.P244R|GPR64_uc004czf.2_Missense_Mutation_p.P236R|GPR64_uc004cza.2_Missense_Mutation_p.P252R|GPR64_uc004cyw.2_Missense_Mutation_p.P258R|GPR64_uc010nfj.2_Missense_Mutation_p.P244R	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	274	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					GGTAGCTTTGGGGACCTGGGA	0.542													0	0	0	0.00278	0	21	30										C	19032082	G	C	19032082	3	2	46	1	0	0	0	0	1	0	0	0	6705	1232	43	4	2288	4	GPR64	23	19032082	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	3223001	19032082	136238478	1752	13449										
MAP3K15	389840	broad.mit.edu	37	chrX	19413274	19413274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caggtactgaacgatattgcGgtgcttaaggtacttgtgca	12	7	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:19413274G>A	uc004czk.1	-	17	2181	c.544C>T	c.(544-546)CGC>TGC	p.R182C	MAP3K15_uc004czj.1_Missense_Mutation_p.R142C	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	707	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					ACGATATTGCGGTGCTTAAGG	0.453													0	0	0	0.007835	0	41	64										A	19413274	G	A	19413274	3	1	46	1	0	0	0	0	1	0	0	0	9249	1116	39	2	1878	2	MAP3K15	23	19413274	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	381192	19413274	135857286	1753	13450										
MAOA	4128	broad.mit.edu	37	chrX	43587477	43587477	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aatgtgacctctgagcctcaCgaagtgtctgccctgtggtt	11	11	3	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:43587477C>A	uc004dfy.2	+	6	742	c.561C>A	c.(559-561)CAC>CAA	p.H187Q	MAOA_uc011mkw.1_Missense_Mutation_p.H54Q	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A	187	Cytoplasmic.				behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTGAGCCTCACGAAGTGTCTG	0.478													1	0	1.22674e-20	0.00874	1.29792e-20	43	101										A	43587477	C	A	43587477	3	1	46	1	0	0	0	0	1	0	0	0	9225	535	19	4	583	4	MAOA	23	43587477	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	24174203	43587477	111683083	1754	13451										
KDM6A	7403	broad.mit.edu	37	chrX	44969394	44969418	+	Frame_Shift_Del	DEL	AAGATTGTGCACGAAAAACAAGCGG	AAGATTGTGCACGAAAAACAAGCGG	-													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gacctacatagtacattgccAagattgtgcacgaaaaacaa							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			AAGATTGTGCACGAAAAACAAGCGG	-	AAGATTGTGCACGAAAAACAAGCGG	AAGATTGTGCACGAAAAACAAGCGG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:44969394_44969418delAAGATTGTGCACGAAAAACAAGCGG	uc004dge.3	+	28	4451_4475	c.4076_4100delAAGATTGTGCACGAAAAACAAGCGG	c.(4075-4101)CAAGATTGTGCACGAAAAACAAGCGGAfs	p.Q1359fs	KDM6A_uc011mkz.1_Frame_Shift_Del_p.Q1411fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.Q1314fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.Q1366fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.Q1063fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.Q998fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1359_1367					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GTACATTGCCAAGATTGTGCACGAAAAACAAGCGGAAACTTGGAA	0.364			D|N|F|S		renal|oesophageal SCC|MM													24	36	---	---								-	44969418	AAGATTGTGCACGAAAAACAAGCGG	-	44969394	7	5	46	1	0	1	0	1	0	0	0	0	8137	130	5	0	4186	0	KDM6A	23	44969394	Frame_Shift_Del	DEL	AAGATTGTGCACGAAAAACAAGCGG	TCGA-DK-A1AC-01A-11D-A13W-08	1381917	44969394	110301166	1755	13452										
CXorf36	79742	broad.mit.edu	37	chrX	45017019	45017019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagcaggcgcagcttgtcacGgtcggtgaagtggtccatga	16	9	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:45017019G>A	uc004dgg.2	-	3	688	c.613C>T	c.(613-615)CGT>TGT	p.R205C		NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	205						extracellular region				lung(1)	1						AGCTTGTCACGGTCGGTGAAG	0.632													0	0	0	0.009096	0	3	8										A	45017019	G	A	45017019	3	1	46	1	0	0	0	0	1	0	0	0	4106	1116	39	2	700	2	CXorf36	23	45017019	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	47625	45017019	110253541	1756	13453										
CDK16	5127	broad.mit.edu	37	chrX	47083090	47083090	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tggtggcggcagtgaccctgGagaggcccccacacgtgctg							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:47083090G>A	uc004dho.2	+	2	530	c.134G>A	c.(133-135)GGA>GAA	p.G45E	CDK16_uc011mli.1_Missense_Mutation_p.G51E|CDK16_uc011mlj.1_Missense_Mutation_p.G45E|CDK16_uc011mlk.1_Missense_Mutation_p.G45E|CDK16_uc011mll.1_Missense_Mutation_p.G119E	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	45							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						AGTGACCCTGGAGAGGCCCCC	0.622													0	0	0	0.004482	0	8	2										A	47083090	G	A	47083090	3	1	46	1	0	0	0	0	1	0	0	0	3132	1174	41	1	378	1	CDK16	23	47083090	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2066071	47083090	108187470	1757	13454	65	2								
CDK16	5127	broad.mit.edu	37	chrX	47083092	47083092	+	Missense_Mutation	SNP	G	G	A													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gtggcggcagtgaccctggaGaggcccccacacgtgctgct							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:47083092G>A	uc004dho.2	+	2	532	c.136G>A	c.(136-138)GAG>AAG	p.E46K	CDK16_uc011mli.1_Missense_Mutation_p.E52K|CDK16_uc011mlj.1_Missense_Mutation_p.E46K|CDK16_uc011mlk.1_Missense_Mutation_p.E46K|CDK16_uc011mll.1_Missense_Mutation_p.E120K	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	46							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						TGACCCTGGAGAGGCCCCCAC	0.627													0	0	0	0.004482	0	8	2										A	47083092	G	A	47083092	3	1	46	1	0	0	0	0	1	0	0	0	3132	943	33	1	380	1	CDK16	23	47083092	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2	47083092	108187468	1758	13455	65	2								
CDK16	5127	broad.mit.edu	37	chrX	47083915	47083915	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ccccacgcaagatctccactGaggtgcttgaccccgtctgg	10	16	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:47083915G>A	uc004dho.2	+	3	730	c.334G>A	c.(334-336)GAG>AAG	p.E112K	CDK16_uc011mli.1_Missense_Mutation_p.E118K|CDK16_uc011mlj.1_Missense_Mutation_p.E112K|CDK16_uc011mlk.1_Missense_Mutation_p.E112K|CDK16_uc011mll.1_Missense_Mutation_p.E186K	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	112							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						GATCTCCACTGAGGTGCTTGA	0.577													0	0	0	0.005443	0	27	3										A	47083915	G	A	47083915	3	1	46	1	0	0	0	0	1	0	0	0	3132	1291	45	1	582	1	CDK16	23	47083915	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	823	47083915	108186645	1759	13456										
TFE3	7030	broad.mit.edu	37	chrX	48891000	48891000	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gggtcactggacttagggatGagagtgcccagttccttgat	14	8	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:48891000G>C	uc004dmb.3	-	8	1354	c.1116C>G	c.(1114-1116)CTC>CTG	p.L372L	TFE3_uc004dmc.3_Silent_p.L267L|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	372	Helix-loop-helix motif.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						ACTTAGGGATGAGAGTGCCCA	0.567			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								0	0	0	0.001984	0	7	17										C	48891000	G	C	48891000	2	2	46	1	0	0	0	0	0	0	0	1	15797	1277	45	1		1	TFE3	23	48891000	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1807085	48891000	106379560	1760	13457										
CACNA1F	778	broad.mit.edu	37	chrX	49079298	49079298	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagtcctcacctgtcaggatCtgggggtgggaagtcactgt	14	10	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:49079298C>T	uc004dnb.2	-	16	2181	c.2119_splice	c.e16-1	p.I707_splice	CACNA1F_uc010nip.2_Splice_Site_p.I696_splice	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CTGTCAGGATCTGGGGGTGGG	0.547													0	0	0	0.007413	0	18	26										T	49079298	C	T	49079298	5	4	46	1	0	0	0	0	0	0	1	0	2543	927	32	1	3947	1	CACNA1F	23	49079298	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	188298	49079298	106191262	1761	13458										
CCNB3	85417	broad.mit.edu	37	chrX	50052841	50052841	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actttcaggatatgattggtGaagataagaattctttcttt	8	4	3	4			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:50052841G>A	uc004dox.3	+	6	1970	c.1672G>A	c.(1672-1674)GAA>AAA	p.E558K	CCNB3_uc004doy.2_Missense_Mutation_p.E558K|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	558					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TATGATTGGTGAAGATAAGAA	0.378													0	0	0	0.008361	0	31	9										A	50052841	G	A	50052841	3	1	46	1	0	0	0	0	1	0	0	0	2914	1291	45	1	1686	1	CCNB3	23	50052841	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	973543	50052841	105217719	1762	13459										
SHROOM4	57477	broad.mit.edu	37	chrX	50370665	50370665	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttattggattccatttgtccCcaggaaattcctgtaaagaa	7	8	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:50370665C>G	uc004dpe.2	-	5	2932	c.2906G>C	c.(2905-2907)GGG>GCG	p.G969A	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	969					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CCATTTGTCCCCAGGAAATTC	0.493													0	0	0	0.006122	0	19	18										G	50370665	C	G	50370665	3	3	46	1	0	0	0	0	1	0	0	0	14296	623	22	4	1595	4	SHROOM4	23	50370665	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	317824	50370665	104899895	1763	13460										
FGD1	2245	broad.mit.edu	37	chrX	54473866	54473866	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gctgcagatgacgctgttctCtgcagccactgaggcctgtt	12	12	1	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:54473866C>T	uc004dtg.2	-	17	3192	c.2458G>A	c.(2458-2460)GAG>AAG	p.E820K		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	820					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						ACGCTGTTCTCTGCAGCCACT	0.537													0	0	0	0.007413	0	18	3										T	54473866	C	T	54473866	3	4	46	1	0	0	0	0	1	0	0	0	5832	922	32	1	435	1	FGD1	23	54473866	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	4103201	54473866	100796694	1764	13461										
PAGE5	90737	broad.mit.edu	37	chrX	55247849	55247849	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	taacaagatcccaatcctcaGaaagaggaaatgaccaagag	8	9	1	5			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:55247849G>A	uc004duj.2	+	2	336	c.94G>A	c.(94-96)GAA>AAA	p.E32K	PAGE5_uc004duk.2_Missense_Mutation_p.E12K	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	32											0						CCAATCCTCAGAAAGAGGAAA	0.328													0	0	0	0.007413	0	19	24										A	55247849	G	A	55247849	3	1	46	1	0	0	0	0	1	0	0	0	11393	943	33	1	100	1	PAGE5	23	55247849	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	773983	55247849	100022711	1765	13462										
ZXDA	7789	broad.mit.edu	37	chrX	57935505	57935505	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cagccatcaaagtcacaaagGaaaggtctctcgccggtgtg	11	11	3	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:57935505G>A	uc004dve.2	-	1	1563	c.1350C>T	c.(1348-1350)TTC>TTT	p.F450F		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	450	C2H2-type 7.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGTCACAAAGGAAAGGTCTCT	0.512													0	0	0	0.010504	0	17	24										A	57935505	G	A	57935505	2	1	46	1	0	0	0	0	0	0	0	1	18247	1165	41	1		1	ZXDA	23	57935505	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	2687656	57935505	97335055	1766	13463										
MED12	9968	broad.mit.edu	37	chrX	70355032	70355032	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cccgagatgtcatcacgtgtGagccacagggctcccttatc	10	14	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:70355032G>A	uc004dyy.2	+	36	5153	c.4954G>A	c.(4954-4956)GAG>AAG	p.E1652K	MED12_uc011mpq.1_Missense_Mutation_p.E1652K|MED12_uc004dyz.2_Missense_Mutation_p.E1652K|MED12_uc004dza.2_Missense_Mutation_p.E1499K|MED12_uc010nla.2_Missense_Mutation_p.E278K	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1652	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCACGTGTGAGCCACAGGG	0.562													0	0	0	0.008871	0	21	1										A	70355032	G	A	70355032	3	1	46	1	0	0	0	0	1	0	0	0	9428	1291	45	1	5096	1	MED12	23	70355032	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	12419527	70355032	84915528	1767	13464										
RPS4X	6191	broad.mit.edu	37	chrX	71494972	71494972	+	Silent	SNP	C	C	T													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcatagatcagacggaaattCtctcccgtcttgtcaatgct							TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:71494972C>T	uc004ear.2	-	4	387	c.291G>A	c.(289-291)GAG>GAA	p.E97E	RPS4X_uc011mqb.1_Silent_p.E97E	NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	97	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					GACGGAAATTCTCTCCCGTCT	0.483													0	0	0	0.008291	0	10	6										T	71494972	C	T	71494972	2	4	46	1	0	0	0	0	0	0	0	1	13645	912	32	1		1	RPS4X	23	71494972	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	1139940	71494972	83775588	1768	13465	66	2								
RPS4X	6191	broad.mit.edu	37	chrX	71494974	71494974	+	Missense_Mutation	SNP	C	C	G													0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	atagatcagacggaaattctCtcccgtcttgtcaatgctga					rs113141010		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:71494974C>G	uc004ear.2	-	4	385	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	RPS4X_uc011mqb.1_Missense_Mutation_p.E97Q	NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	97	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					CGGAAATTCTCTCCCGTCTTG	0.483													0	0	0	0.008291	0	10	6										G	71494974	C	G	71494974	3	3	46	1	0	0	0	0	1	0	0	0	13645	922	32	1	518	1	RPS4X	23	71494974	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	2	71494974	83775586	1769	13466	66	2								
PHKA1	5255	broad.mit.edu	37	chrX	71846900	71846900	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	caagcttgttccatcttcatCttgaaatgaacagaatttta	5	8	3	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:71846900C>G	uc004eax.3	-	17	2016	c.1715_splice	c.e17-1	p.D572_splice	PHKA1_uc004eay.3_Splice_Site_p.D572_splice|PHKA1_uc011mqi.1_Splice_Site_p.D572_splice	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform						glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					CCATCTTCATCTTGAAATGAA	0.363													0	0	0	0.00333	0	26	11										G	71846900	C	G	71846900	5	3	46	1	0	0	0	0	0	0	1	0	11843	927	32	1	2021	1	PHKA1	23	71846900	Splice_Site	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	351926	71846900	83423660	1770	13467										
RLIM	51132	broad.mit.edu	37	chrX	73812835	73812835	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gttgtatttccagtttgtctGacagagttaagccagtctat	9	7	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:73812835G>A	uc004ebu.2	-	5	605	c.315C>T	c.(313-315)GTC>GTT	p.V105V	RLIM_uc004ebw.2_Silent_p.V105V	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	105					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CAGTTTGTCTGACAGAGTTAA	0.428													0	0	0	0.00623	0	39	22										A	73812835	G	A	73812835	2	1	46	1	0	0	0	0	0	0	0	1	13390	1277	45	1		1	RLIM	23	73812835	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1965935	73812835	81457725	1771	13468										
PCDH19	57526	broad.mit.edu	37	chrX	99661856	99661856	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	accaggtagcctatgccagaGttgcggggtatgtagacctc	13	10	0	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:99661856G>C	uc010nmz.2	-	1	3416	c.1740C>G	c.(1738-1740)AAC>AAG	p.N580K	PCDH19_uc004efw.3_Missense_Mutation_p.N580K|PCDH19_uc004efx.3_Missense_Mutation_p.N580K	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	580	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CTATGCCAGAGTTGCGGGGTA	0.587													0	0	0	0.006122	0	17	12										C	99661856	G	C	99661856	3	2	46	1	0	0	0	0	1	0	0	0	11514	1020	36	4	1730	4	PCDH19	23	99661856	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	25849021	99661856	55608704	1772	13469										
RNF128	79589	broad.mit.edu	37	chrX	105937496	105937496	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	actgagtttagtaatactaaGaagccctggattgcgctgat	10	7	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:105937496G>C	uc004emk.2	+	1	429	c.264G>C	c.(262-264)AAG>AAC	p.K88N		NM_024539	NP_078815	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTAATACTAAGAAGCCCTGGA	0.408													0	0	0	0.008871	0	21	11										C	105937496	G	C	105937496	3	2	46	1	0	0	0	0	1	0	0	0	13436	933	33	1	266	1	RNF128	23	105937496	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	6275640	105937496	49333064	1773	13470										
GRIA3	2892	broad.mit.edu	37	chrX	122561889	122561889	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tcgctgctttcctgactgtgGagaggatggtttctcccata	11	10	1	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:122561889G>C	uc004etq.3	+	13	2268	c.1975G>C	c.(1975-1977)GAG>CAG	p.E659Q	GRIA3_uc004etr.3_Missense_Mutation_p.E659Q|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	659	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CCTGACTGTGGAGAGGATGGT	0.463													0	0	0	0.01441	0	51	24										C	122561889	G	C	122561889	3	2	46	1	0	0	0	0	1	0	0	0	6769	1175	41	1	2021	1	GRIA3	23	122561889	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	16624393	122561889	32708671	1774	13471										
GRIA3	2892	broad.mit.edu	37	chrX	122598816	122598816	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	agacggagtggcccgagtgcGaaagtccaagggaaagttcg	16	8	0	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:122598816G>A	uc004etq.3	+	14	2470	c.2177G>A	c.(2176-2178)CGA>CAA	p.R726Q	GRIA3_uc004etr.3_Missense_Mutation_p.R726Q|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	726	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GCCCGAGTGCGAAAGTCCAAG	0.458													0	0	0	0.004656	0	24	13										A	122598816	G	A	122598816	3	1	46	1	0	0	0	0	1	0	0	0	6769	1058	37	1	2227	1	GRIA3	23	122598816	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	36927	122598816	32671744	1775	13472										
USP26	83844	broad.mit.edu	37	chrX	132162129	132162129	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	tattttccacttttgaaataCagcaccagtctatctttctt	3	10	3	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:132162129C>T	uc010nrm.1	-	6	590	c.120G>A	c.(118-120)CTG>CTA	p.L40L	USP26_uc011mvf.1_Silent_p.L40L	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	40					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					TTTTGAAATACAGCACCAGTC	0.353													0	0	0	0.012319	0	23	17										T	132162129	C	T	132162129	2	4	46	1	0	0	0	0	0	0	0	1	17054	465	17	2		2	USP26	23	132162129	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	9563313	132162129	23108431	1776	13473										
FGF13	2258	broad.mit.edu	37	chrX	138286239	138286239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	acccttagaagcatctttctCctctttgggcttggtcacct	7	13	4	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:138286239C>T	uc004faq.2	-	1	207	c.31G>A	c.(31-33)GAG>AAG	p.E11K	FGF13_uc004far.2_5'UTR|FGF13_uc011mwj.1_Missense_Mutation_p.E11K|FGF13_uc011mwk.1_Missense_Mutation_p.E11K	NM_001139502	NP_001132974	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 3	Error:Variant_position_missing_in_Q92913_after_alignment					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCATCTTTCTCCTCTTTGGGC	0.622													0	0	0	0.008291	0	11	6										T	138286239	C	T	138286239	3	4	46	1	0	0	0	0	1	0	0	0	5842	864	30	1	983	1	FGF13	23	138286239	Missense_Mutation	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	6124110	138286239	16984321	1777	13474										
ZNF185	7739	broad.mit.edu	37	chrX	152137987	152137987	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gagactgtccaaagattaccCtagaacatcttggtatctgc	8	10	2	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:152137987C>T	uc010ntv.1	+	21	1967	c.1930C>T	c.(1930-1932)CTA>TTA	p.L644L	ZNF185_uc011myg.1_Silent_p.L676L|ZNF185_uc011myh.1_Silent_p.L647L|ZNF185_uc011myi.1_Silent_p.L615L|ZNF185_uc011myj.1_Silent_p.L585L|ZNF185_uc011myk.1_Silent_p.L645L|ZNF185_uc004fgw.3_Silent_p.L423L|ZNF185_uc004fgu.2_Silent_p.L273L|ZNF185_uc004fgv.2_Silent_p.L341L|ZNF185_uc004fgx.2_Silent_p.L282L	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	644	LIM zinc-binding.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGATTACCCTAGAACATCT	0.473													0	0	0	0.004482	0	7	3										T	152137987	C	T	152137987	2	4	46	1	0	0	0	0	0	0	0	1	17749	680	24	2		2	ZNF185	23	152137987	Silent	SNP	C	TCGA-DK-A1AC-01A-11D-A13W-08	13851748	152137987	3132573	1778	13475										
HCFC1	3054	broad.mit.edu	37	chrX	153223253	153223253	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctggatgatctgagtcacagGacccgtggacgcctggcctg	14	12	2	2			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:153223253G>C	uc004fjp.2	-	12	2641	c.2113C>G	c.(2113-2115)CCT>GCT	p.P705A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	705	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGTCACAGGACCCGTGGAC	0.547													0	0	0	0.012319	0	19	13										C	153223253	G	C	153223253	3	2	46	1	0	0	0	0	1	0	0	0	6991	1174	41	1	4054	1	HCFC1	23	153223253	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1085266	153223253	2047307	1779	13476										
FLNA	2316	broad.mit.edu	37	chrX	153580262	153580262	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ttcccagtacctggctcctgGaccacataagccacaccaca	6	17	0	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:153580262G>C	uc004fkk.2	-	42	7146	c.6897C>G	c.(6895-6897)GTC>GTG	p.V2299V	FLNA_uc004fki.2_Silent_p.V342V|FLNA_uc011mzn.1_Silent_p.V432V|FLNA_uc010nuu.1_Silent_p.V2291V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2299	Filamin 21.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGGCTCCTGGACCACATAAG	0.637													0	0	0	0.004482	0	9	7										C	153580262	G	C	153580262	2	2	46	1	0	0	0	0	0	0	0	1	5933	1161	41	1		1	FLNA	23	153580262	Silent	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	357009	153580262	1690298	1780	13477										
IL9R	3581	broad.mit.edu	37	chrX	155232652	155232652	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	ctgcatctgcacctgtgtctGcttgggagtctctgtcacag	11	12	4	0			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:155232652G>A	uc004fnv.1	+	2	289	c.110G>A	c.(109-111)TGC>TAC	p.C37Y	IL9R_uc010nvn.2_Missense_Mutation_p.C16Y|IL9R_uc004fnu.1_Missense_Mutation_p.C84Y	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	37					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACCTGTGTCTGCTTGGGAGTC	0.597													0	0	0	0.00333	0	24	56										A	155232652	G	A	155232652	3	1	46	1	0	0	0	0	1	0	0	0	7708	1319	46	2	116	2	IL9R	23	155232652	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	1652390	155232652	37908	1781	13478										
USP9Y	8287	broad.mit.edu	37	chrY	14885574	14885574	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	cctcaggcaaaacaaatatgGaagtgcttagcagaaaatgc	9	8	1	1			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrY:14885574G>T	uc004fst.1	+	17	2991	c.2046G>T	c.(2044-2046)TGG>TGT	p.W682C	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	682					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AACAAATATGGAAGTGCTTAG	0.393													1	0	2.31418e-15	0.01441	2.43303e-15	51	20										T	14885574	G	T	14885574	3	4	46	1	0	0	0	0	1	0	0	0	17088	1183	41	3	2104	3	USP9Y	24	14885574	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08		14885574	44487992	1782	13479										
USP9Y	8287	broad.mit.edu	37	chrY	14885804	14885804	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	aaggaaactaatagcaaaaaGaagatcctatatgatggatg	9	4	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrY:14885804G>C	uc004fst.1	+	17	3221	c.2276G>C	c.(2275-2277)AGA>ACA	p.R759T	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	759					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						ATAGCAAAAAGAAGATCCTAT	0.353													0	0	0	0.012319	0	21	8										C	14885804	G	C	14885804	3	2	46	1	0	0	0	0	1	0	0	0	17088	942	33	1	2334	1	USP9Y	24	14885804	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	230	14885804	44487762	1783	13480										
USP9Y	8287	broad.mit.edu	37	chrY	14885824	14885824	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.548332391181458	970	0	4.2577221066294	4.89634146341463	4.08079313729054	1.04990174623831e-107	1.3648722701098e-105	742	gaagatcctatatgatggatGatttggaattaattggacta	10	3	0	3			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrY:14885824G>T	uc004fst.1	+	17	3241	c.2296G>T	c.(2296-2298)GAT>TAT	p.D766Y	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	766					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TATGATGGATGATTTGGAATT	0.313													1	0	1.33834e-09	0.007413	1.38957e-09	18	6										T	14885824	G	T	14885824	3	4	46	1	0	0	0	0	1	0	0	0	17088	1290	45	3	2354	3	USP9Y	24	14885824	Missense_Mutation	SNP	G	TCGA-DK-A1AC-01A-11D-A13W-08	20	14885824	44487742	1784	13481										
H6PD	9563	broad.mit.edu	37	chr1	9324830	9324830	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agatcaccacgctggtgagcCgggtgggccatgagcccaag	15	12	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:9324830C>T	uc001apt.2	+	5	2551	c.2278C>T	c.(2278-2280)CGG>TGG	p.R760W		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	760	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GCTGGTGAGCCGGGTGGGCCA	0.637													0	0	0	0.010729	0	12	30										T	9324830	C	T	9324830	3	4	47	1	0	0	0	0	1	0	0	0	6936	643	23	2	2292	2	H6PD	1	9324830	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		9324830	239925791	1	13482										
ATP13A2	23400	broad.mit.edu	37	chr1	17313397	17313397	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agagagaagaccacggtgttCtcgtagttgggcaggttgtc	15	7	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:17313397C>G	uc001baa.2	-	27	3328	c.3138G>C	c.(3136-3138)GAG>GAC	p.E1046D	ATP13A2_uc001azz.1_Missense_Mutation_p.E193D|ATP13A2_uc001bab.2_Missense_Mutation_p.E1041D|ATP13A2_uc001bac.2_Missense_Mutation_p.E1002D	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	1046	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CCACGGTGTTCTCGTAGTTGG	0.627													0	0	0	0.00308	0	7	27										G	17313397	C	G	17313397	3	3	47	1	0	0	0	0	1	0	0	0	1124	912	32	1	652	1	ATP13A2	1	17313397	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7988567	17313397	231937224	2	13483										
HSPG2	3339	broad.mit.edu	37	chr1	22176612	22176612	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgaccagcaacgaggcagttCaggtccagggtctgcccctc	12	14	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:22176612C>G	uc001bfj.2	-	57	7408	c.7368G>C	c.(7366-7368)CTG>CTC	p.L2456L	HSPG2_uc009vqd.2_Silent_p.L2457L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2456	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGAGGCAGTTCAGGTCCAGGG	0.662													0	0	0	0.00623	0	38	86										G	22176612	C	G	22176612	2	3	47	1	0	0	0	0	0	0	0	1	7430	813	29	1		1	HSPG2	1	22176612	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	4863215	22176612	227074009	3	13484										
KDM1A	23028	broad.mit.edu	37	chr1	23382467	23382467	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tattataggctctggggtctCaggcttggcagcagctcgac	13	10	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:23382467C>G	uc001bgi.2	+	6	1015	c.866C>G	c.(865-867)TCA>TGA	p.S289*	KDM1A_uc001bgj.2_Nonsense_Mutation_p.S309*	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	289	FAD (Potential).	FAD.			blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						TCTGGGGTCTCAGGCTTGGCA	0.358													0	0	0	0.01441	0	44	169										G	23382467	C	G	23382467	4	3	47	1	0	0	0	0	0	1	0	0	8122	838	29	1	952	1	KDM1A	1	23382467	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1205855	23382467	225868154	4	13485										
MYOM3	127294	broad.mit.edu	37	chr1	24392393	24392393	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acacttgcctcttcaatgcaGagaagtcccgttcccgtctc	7	15	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:24392393G>A	uc001bin.3	-	29	3685	c.3522C>T	c.(3520-3522)CTC>CTT	p.L1174L	MYOM3_uc001bil.3_Silent_p.L67L|MYOM3_uc001bim.3_Silent_p.L831L|MYOM3_uc001bio.2_Silent_p.L1174L	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1174	Ig-like C2-type 3.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTTCAATGCAGAGAAGTCCCG	0.562													0	0	0	0.01441	0	55	138										A	24392393	G	A	24392393	2	1	47	1	0	0	0	0	0	0	0	1	10093	929	33	1		1	MYOM3	1	24392393	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1009926	24392393	224858228	5	13486										
ARID1A	8289	broad.mit.edu	37	chr1	27058057	27058057	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cccagtctcagcagtcccagCaaactgcctattcccagcag	7	17	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:27058057C>T	uc001bmv.1	+	3	2138	c.1765C>T	c.(1765-1767)CAA>TAA	p.Q589*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q589*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q589*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q206*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	589					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAGTCCCAGCAAACTGCCTA	0.607			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	81	91										T	27058057	C	T	27058057	4	4	47	1	0	0	0	0	0	1	0	0	913	711	25	2	1775	2	ARID1A	1	27058057	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2665664	27058057	222192564	6	13487										
MACF1	23499	broad.mit.edu	37	chr1	39888185	39888185	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	catggaagagatcaatgctcGatggaatacattgaataaaa	9	5	1	2	rs148666575	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:39888185G>A	uc010oiu.1	+	23	11407	c.11276G>A	c.(11275-11277)CGA>CAA	p.R3759Q	MACF1_uc010ois.1_Missense_Mutation_p.R3257Q|MACF1_uc001cda.1_Missense_Mutation_p.R3144Q|MACF1_uc001cdc.1_Missense_Mutation_p.R2323Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5324	Spectrin 6.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ATCAATGCTCGATGGAATACA	0.428													0	0	0	0.014323	0	21	50										A	39888185	G	A	39888185	3	1	47	1	0	0	0	0	1	0	0	0	9144	1058	37	1	16135	1	MACF1	1	39888185	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	12830128	39888185	209362436	7	13488										
MACF1	23499	broad.mit.edu	37	chr1	39889764	39889764	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcttcaagcagaaggaggcaGaatagcccagtcagcagagc	13	10	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:39889764G>C	uc010oiu.1	+	25	11665	c.11534G>C	c.(11533-11535)AGA>ACA	p.R3845T	MACF1_uc010ois.1_Missense_Mutation_p.R3343T|MACF1_uc001cda.1_Missense_Mutation_p.R3230T|MACF1_uc001cdc.1_Missense_Mutation_p.R2409T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5410	Spectrin 7.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGGAGGCAGAATAGCCCAG	0.473													0	0	0	0.004007	0	15	63										C	39889764	G	C	39889764	3	2	47	1	0	0	0	0	1	0	0	0	9144	942	33	1	16401	1	MACF1	1	39889764	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1579	39889764	209360857	8	13489										
CLDN19	149461	broad.mit.edu	37	chr1	43205572	43205572	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttgcccagtgctctgggaggCgcaggacatccagagccctt	13	13	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:43205572C>T	uc001cht.1	-	1	354	c.163G>A	c.(163-165)GCC>ACC	p.A55T	CLDN19_uc001chu.2_Missense_Mutation_p.A55T|CLDN19_uc010ojv.1_Missense_Mutation_p.A55T	NM_148960	NP_683763	Q8N6F1	CLD19_HUMAN	claudin 19 isoform a	55	Extracellular (Potential).				calcium-independent cell-cell adhesion|response to stimulus|visual perception	basolateral plasma membrane|integral to membrane|tight junction	identical protein binding				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTGGGAGGCGCAGGACATC	0.647													0	0	0	0.009096	0	4	16										T	43205572	C	T	43205572	3	4	47	1	0	0	0	0	1	0	0	0	3480	768	27	2	647	2	CLDN19	1	43205572	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	3315808	43205572	206045049	9	13490										
ATP6V0B	533	broad.mit.edu	37	chr1	44441505	44441505	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	catttttgatttgggcttccGctttgatgtggcatggtaag	12	6	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:44441505G>T	uc001cld.2	+	2	212	c.101G>T	c.(100-102)CGC>CTC	p.R34L	ATP6V0B_uc001clc.2_Missense_Mutation_p.R34L|ATP6V0B_uc001cle.2_Intron|ATP6V0B_uc001clf.2_5'UTR	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	34	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				TTGGGCTTCCGCTTTGATGTG	0.537													1	0	1.68136e-41	0.01441	1.90984e-41	77	203										T	44441505	G	T	44441505	3	4	47	1	0	0	0	0	1	0	0	0	1171	1087	38	4	107	4	ATP6V0B	1	44441505	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1235933	44441505	204809116	10	13491										
NRD1	4898	broad.mit.edu	37	chr1	52305975	52305975	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	attatcctcagtatcaagatCatcatcatgttcatcatcaa	3	10	8	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:52305975C>T	uc001ctc.3	-	2	875	c.553G>A	c.(553-555)GAT>AAT	p.D185N	NRD1_uc009vzb.2_5'UTR|NRD1_uc001ctd.3_Missense_Mutation_p.D185N|NRD1_uc001cte.2_Missense_Mutation_p.D53N|NRD1_uc001ctf.2_Missense_Mutation_p.D185N|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.D53N|NRD1_uc001ctg.1_5'Flank	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						gtatcaagatcatcatcatgt	0.169													0	0	0	0.006122	0	18	42										T	52305975	C	T	52305975	3	4	47	1	0	0	0	0	1	0	0	0	10645	826	29	1	3234	1	NRD1	1	52305975	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7864470	52305975	196944646	11	13492										
LEPR	3953	broad.mit.edu	37	chr1	66064359	66064359	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acaggctgacaagattgtctCagctacatccctgctagtag	9	11	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:66064359C>T	uc001dci.2	+	8	1068	c.866C>T	c.(865-867)TCA>TTA	p.S289L	LEPR_uc001dcg.2_Missense_Mutation_p.S289L|LEPR_uc001dch.2_Missense_Mutation_p.S289L|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.S289L|LEPR_uc001dck.2_Missense_Mutation_p.S289L	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	289	Extracellular (Potential).|Fibronectin type-III 1.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AAGATTGTCTCAGCTACATCC	0.333													0	0	0	0.010504	0	16	89										T	66064359	C	T	66064359	3	4	47	1	0	0	0	0	1	0	0	0	8728	838	29	1	888	1	LEPR	1	66064359	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	13758384	66064359	183186262	12	13493										
LRRC8D	55144	broad.mit.edu	37	chr1	90400469	90400469	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gatgtggctccacatcttacAaagttagtcattcataatga	7	8	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:90400469A>G	uc001dnm.2	+	3	2267	c.1842A>G	c.(1840-1842)ACA>ACG	p.T614T	LRRC8D_uc001dnn.2_Silent_p.T614T	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	614	LRR 5.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		CACATCTTACAAAGTTAGTCA	0.438													0	0	0	0.01441	0	44	99										G	90400469	A	G	90400469	2	3	47	1	0	0	0	0	0	0	0	1	9024	117	5	5		5	LRRC8D	1	90400469	Silent	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	24336110	90400469	158850152	13	13494										
DNTTIP2	30836	broad.mit.edu	37	chr1	94343392	94343392	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccagtactactttctggatgCgcttgaatcccattagcagc	8	12	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:94343392C>T	uc001dqf.2	-	2	137	c.99G>A	c.(97-99)GCG>GCA	p.A33A	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Intron	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	33					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTTCTGGATGCGCTTGAATCC	0.443													0	0	0	0.017118	0	35	27										T	94343392	C	T	94343392	2	4	47	1	0	0	0	0	0	0	0	1	4682	755	27	2		2	DNTTIP2	1	94343392	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	3942923	94343392	154907229	14	13495										
VTCN1	79679	broad.mit.edu	37	chr1	117699368	117699368	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgaacatttcatcctgctcCgacagctcatctttgccttc	5	15	3	1	rs115383914	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:117699368C>A	uc001ehb.2	-	3	345	c.273G>T	c.(271-273)TCG>TCT	p.S91S	VTCN1_uc001ehc.2_5'UTR|VTCN1_uc009whf.1_Intron	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	91	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		CATCCTGCTCCGACAGCTCAT	0.458													1	0	3.99451e-17	0.009535	4.29772e-17	32	94										A	117699368	C	A	117699368	2	1	47	1	0	0	0	0	0	0	0	1	17231	639	23	4		4	VTCN1	1	117699368	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	23355976	117699368	131551253	15	13496										
PDE4DIP	9659	broad.mit.edu	37	chr1	144871840	144871840	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agctgagggcaatggtgcctGaggaaggctagccagcttgg	17	8	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:144871840G>C	uc001elw.3	-	32	5413	c.5122C>G	c.(5122-5124)CAG>GAG	p.Q1708E	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.Q715E	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1708					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AATGGTGCCTGAGGAAGGCTA	0.507			T	PDGFRB	MPD								0	0	0	0.001984	0	7	168										C	144871840	G	C	144871840	3	2	47	1	0	0	0	0	1	0	0	0	11643	1299	45	1	1970	1	PDE4DIP	1	144871840	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	27172472	144871840	104378781	16	13497										
PDE4DIP	9659	broad.mit.edu	37	chr1	144918839	144918839	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcatgtaaactcacctgaagCaactgctccttgtgactcag	7	12	3	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:144918839C>T	uc001elw.3	-	10	1638	c.1347G>A	c.(1345-1347)TTG>TTA	p.L449L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L515L|PDE4DIP_uc001emc.1_Silent_p.L449L|PDE4DIP_uc001emd.1_Silent_p.L449L|PDE4DIP_uc001emb.1_Silent_p.L612L|PDE4DIP_uc001eme.1_5'UTR|PDE4DIP_uc001emf.1_Silent_p.L236L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	449	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCACCTGAAGCAACTGCTCCT	0.403			T	PDGFRB	MPD								0	0	0	0.01441	0	181	732										T	144918839	C	T	144918839	2	4	47	1	0	0	0	0	0	0	0	1	11643	709	25	2		2	PDE4DIP	1	144918839	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	46999	144918839	104331782	17	13498										
HORMAD1	84072	broad.mit.edu	37	chr1	150675844	150675844	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttcagacatatcaagttcaGatgttttattgactaactgc	6	7	3	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:150675844G>T	uc001evk.1	-	13	1080	c.974C>A	c.(973-975)TCT>TAT	p.S325Y	HORMAD1_uc001evl.1_Missense_Mutation_p.S318Y|HORMAD1_uc001evm.1_Missense_Mutation_p.S245Y	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	325					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			ATCAAGTTCAGATGTTTTATT	0.274													1	0	3.09899e-07	0.004482	3.19705e-07	7	45										T	150675844	G	T	150675844	3	4	47	1	0	0	0	0	1	0	0	0	7286	942	33	3	222	3	HORMAD1	1	150675844	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	5757005	150675844	98574777	18	13499										
PIP5K1A	8394	broad.mit.edu	37	chr1	151205031	151205031	+	Missense_Mutation	SNP	C	C	T													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tctctgtttgccccagtattCcctctgcagtgagccgctga							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205031C>T	uc001exj.2	+	7	943	c.491C>T	c.(490-492)TCC>TTC	p.S164F	PIP5K1A_uc001exi.2_Missense_Mutation_p.S151F|PIP5K1A_uc010pcu.1_Missense_Mutation_p.S152F|PIP5K1A_uc001exk.2_Missense_Mutation_p.S151F|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	164	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCCCAGTATTCCCTCTGCAGT	0.423													0	0	0	0.016522	0	13	61										T	151205031	C	T	151205031	3	4	47	1	0	0	0	0	1	0	0	0	11939	855	30	1	517	1	PIP5K1A	1	151205031	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	529187	151205031	98045590	19	13500	67	2	1	49		4	3	83	N	C	2.696231e-07
PIP5K1A	8394	broad.mit.edu	37	chr1	151205035	151205035	+	Silent	SNP	C	C	T													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgtttgccccagtattccctCtgcagtgagccgctgattga							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205035C>T	uc001exj.2	+	7	947	c.495C>T	c.(493-495)CTC>CTT	p.L165L	PIP5K1A_uc001exi.2_Silent_p.L152L|PIP5K1A_uc010pcu.1_Silent_p.L153L|PIP5K1A_uc001exk.2_Silent_p.L152L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	165	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGTATTCCCTCTGCAGTGAGC	0.428													0	0	0	0.016522	0	12	57										T	151205035	C	T	151205035	2	4	47	1	0	0	0	0	0	0	0	1	11939	900	32	1		1	PIP5K1A	1	151205035	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	4	151205035	98045586	20	13501	67	2	1	49		4	3	83	N	C	2.696231e-07
PIP5K1A	8394	broad.mit.edu	37	chr1	151205059	151205059	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agtgagccgctgattgaactCtgtagctctggagctagtgg	14	8	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205059C>T	uc001exj.2	+	7	971	c.519C>T	c.(517-519)CTC>CTT	p.L173L	PIP5K1A_uc001exi.2_Silent_p.L160L|PIP5K1A_uc010pcu.1_Silent_p.L161L|PIP5K1A_uc001exk.2_Silent_p.L160L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	173	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGATTGAACTCTGTAGCTCTG	0.458													0	0	0	0.012213	0	21	65										T	151205059	C	T	151205059	2	4	47	1	0	0	0	0	0	0	0	1	11939	900	32	1		1	PIP5K1A	1	151205059	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	24	151205059	98045562	21	13502			1	49		4	3	83	N	C	2.696231e-07
PIP5K1A	8394	broad.mit.edu	37	chr1	151205113	151205113	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtgtccagcgacgatgagttCattattaagacagtccaaca	9	9	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:151205113C>G	uc001exj.2	+	7	1025	c.573C>G	c.(571-573)TTC>TTG	p.F191L	PIP5K1A_uc001exi.2_Missense_Mutation_p.F178L|PIP5K1A_uc010pcu.1_Missense_Mutation_p.F179L|PIP5K1A_uc001exk.2_Missense_Mutation_p.F178L|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	191	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACGATGAGTTCATTATTAAGA	0.488													0	0	0	0.00623	0	37	70										G	151205113	C	G	151205113	3	3	47	1	0	0	0	0	1	0	0	0	11939	825	29	1	599	1	PIP5K1A	1	151205113	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	54	151205113	98045508	22	13503			1	49		4	3	83	N	C	2.696231e-07
FLG	2312	broad.mit.edu	37	chr1	152282887	152282887	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctcctctgcttgaccccgggTgtccacgaatggtgtcctga	11	14	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:152282887T>C	uc001ezu.1	-	3	4511	c.4475A>G	c.(4474-4476)CAC>CGC	p.H1492R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1492	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCCCGGGTGTCCACGAAT	0.587									Ichthyosis				0	0	0	0.01441	0	119	737										C	152282887	T	C	152282887	3	2	47	1	0	0	0	0	1	0	0	0	5922	1696	59	5	7714	5	FLG	1	152282887	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	1077774	152282887	96967734	23	13504										
CD1C	911	broad.mit.edu	37	chr1	158263070	158263070	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tggtgattctaatagtccttGtgttatggtttaagaagcac	10	5	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:158263070G>T	uc001fru.2	+	5	1250	c.958G>T	c.(958-960)GTG>TTG	p.V320L	CD1C_uc001frv.2_Intron	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	320	Helical; (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AATAGTCCTTGTGTTATGGTT	0.393													1	0	1.69816e-31	0.01441	1.9024e-31	78	736										T	158263070	G	T	158263070	3	4	47	1	0	0	0	0	1	0	0	0	2976	1377	48	4	976	4	CD1C	1	158263070	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	5980183	158263070	90987551	24	13505										
NCSTN	23385	broad.mit.edu	37	chr1	160326942	160326942	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gggccttgtctcctgcctttGaactgagtcagtggagctct	12	11	3	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:160326942G>C	uc001fvx.2	+	16	2030	c.1906G>C	c.(1906-1908)GAA>CAA	p.E636Q	NCSTN_uc001fvy.2_Missense_Mutation_p.E616Q|NCSTN_uc010pjf.1_Missense_Mutation_p.E498Q|NCSTN_uc001fvz.2_Missense_Mutation_p.E416Q|NCSTN_uc010pjg.1_Missense_Mutation_p.E378Q	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	636	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCCTGCCTTTGAACTGAGTCA	0.537													0	0	0	0.015359	0	32	375										C	160326942	G	C	160326942	3	2	47	1	0	0	0	0	1	0	0	0	10241	1291	45	1	1968	1	NCSTN	1	160326942	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	2063872	160326942	88923679	25	13506										
RGS4	5999	broad.mit.edu	37	chr1	163044271	163044271	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctatcttgatttggtcaaccCgtccagctgtggggcagaaa	11	10	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:163044271C>G	uc009wuy.2	+	5	1050	c.539C>G	c.(538-540)CCG>CGG	p.P180R	RGS4_uc001gcl.3_Missense_Mutation_p.P277R|RGS4_uc009wuz.2_3'UTR|RGS4_uc009wva.2_Missense_Mutation_p.P162R	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	180					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						TTGGTCAACCCGTCCAGCTGT	0.517													0	0	0	0.01441	0	56	436										G	163044271	C	G	163044271	3	3	47	1	0	0	0	0	1	0	0	0	13307	652	23	4	852	4	RGS4	1	163044271	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2717329	163044271	86206350	26	13507										
DCAF6	55827	broad.mit.edu	37	chr1	168007717	168007717	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cacaataaaactgaactttaCagatgaatggtaagttaata	6	5	0	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:168007717C>T	uc001gew.2	+	11	1729	c.1487C>T	c.(1486-1488)ACA>ATA	p.T496I	DCAF6_uc001gev.2_Missense_Mutation_p.T516I|DCAF6_uc001gex.2_Missense_Mutation_p.T573I|DCAF6_uc010plk.1_Missense_Mutation_p.T542I|DCAF6_uc001gey.2_Missense_Mutation_p.T369I	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	496					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGAACTTTACAGATGAATGG	0.333													0	0	0	0.010818	0	30	142										T	168007717	C	T	168007717	3	4	47	1	0	0	0	0	1	0	0	0	4274	478	17	2	1593	2	DCAF6	1	168007717	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	4963446	168007717	81242904	27	13508										
FAM20B	9917	broad.mit.edu	37	chr1	179019501	179019501	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcagcctttcacttggacagGtgcgtatgatcacagcagct	11	11	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:179019501G>A	uc001gmc.2	+	3	757	c.464_splice	c.e3+1	p.R155_splice		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor							Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						ACTTGGACAGGTGCGTATGAT	0.443													0	0	0	0.01441	0	62	123										A	179019501	G	A	179019501	5	1	47	1	0	0	0	0	0	0	1	0	5538	1275	44	2	471	2	FAM20B	1	179019501	Splice_Site	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	11011784	179019501	70231120	28	13509										
RGS18	64407	broad.mit.edu	37	chr1	192127775	192127775	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttttagagagaagatggaaaCaacattgcttttcttttctc	7	6	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:192127775C>T	uc001gsg.2	+	1	184	c.8C>T	c.(7-9)ACA>ATA	p.T3I		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	3					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						AAGATGGAAACAACATTGCTT	0.264													0	0	0	0.003163	0	16	45										T	192127775	C	T	192127775	3	4	47	1	0	0	0	0	1	0	0	0	13300	478	17	2	10	2	RGS18	1	192127775	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	13108274	192127775	57122846	29	13510										
KIF14	9928	broad.mit.edu	37	chr1	200587160	200587160	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcgttgtcaagtgtcctgatCtaacaacttcagtctgactc	7	11	4	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:200587160C>G	uc010ppk.1	-	2	1131	c.692G>C	c.(691-693)AGA>ACA	p.R231T	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	231	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						GTGTCCTGATCTAACAACTTC	0.408													0	0	0	0.01441	0	379	65										G	200587160	C	G	200587160	3	3	47	1	0	0	0	0	1	0	0	0	8276	913	32	1	4370	1	KIF14	1	200587160	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	8459385	200587160	48663461	30	13511										
CDC42BPA	8476	broad.mit.edu	37	chr1	227204728	227204728	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccgactattatctgatgtttCaggtactaccagttcgtccc	7	12	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:227204728C>G	uc001hqr.2	-	32	5477	c.4534G>C	c.(4534-4536)GAA>CAA	p.E1512Q	CDC42BPA_uc001hqq.2_Missense_Mutation_p.E811Q|CDC42BPA_uc001hqs.2_Missense_Mutation_p.E1431Q|CDC42BPA_uc009xes.2_Missense_Mutation_p.E1484Q|CDC42BPA_uc010pvs.1_Missense_Mutation_p.E1492Q|CDC42BPA_uc001hqp.2_Missense_Mutation_p.E668Q|CDC42BPA_uc001hqt.2_Missense_Mutation_p.E390Q	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1525					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TCTGATGTTTCAGGTACTACC	0.363													0	0	0	0.01441	0	60	103										G	227204728	C	G	227204728	3	3	47	1	0	0	0	0	1	0	0	0	3072	835	29	1	645	1	CDC42BPA	1	227204728	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	26617568	227204728	22045893	31	13512										
HEATR1	55127	broad.mit.edu	37	chr1	236729993	236729993	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgtttttgtgacatactgttCaaaaagcaagatgaggagaa	10	4	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:236729993C>T	uc001hyd.1	-	30	4386	c.4261G>A	c.(4261-4263)GAA>AAA	p.E1421K	HEATR1_uc009xgh.1_Missense_Mutation_p.E583K	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1421					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACATACTGTTCAAAAAGCAAG	0.488													0	0	0	0.009535	0	28	36										T	236729993	C	T	236729993	3	4	47	1	0	0	0	0	1	0	0	0	7027	835	29	1	2237	1	HEATR1	1	236729993	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	9525265	236729993	12520628	32	13513										
OR1C1	26188	broad.mit.edu	37	chr1	247921243	247921243	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taggacagtatgcaggagggCgtggaggtaagtaacaagcc	16	6	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr1:247921243C>A	uc010pza.1	-	1	466	c.466G>T	c.(466-468)GCC>TCC	p.A156S		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGCAGGAGGGCGTGGAGGTAA	0.498													1	0	1.49673e-21	0.00623	1.64288e-21	41	7										A	247921243	C	A	247921243	3	1	47	1	0	0	0	0	1	0	0	0	10952	768	27	4	480	4	OR1C1	1	247921243	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	11191250	247921243	1329378	33	13514										
PKDCC	91461	broad.mit.edu	37	chr2	42284440	42284440	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taccaccacgggagctgcctCctttcagtgttcaacctggc	9	15	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:42284440C>T	uc002rsg.2	+	6	1481	c.1302C>T	c.(1300-1302)CTC>CTT	p.L434L		NM_138370	NP_612379	Q504Y2	PKDCC_HUMAN	protein kinase-like protein SgK493	434	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(1)	1						GGAGCTGCCTCCTTTCAGTGT	0.592													0	0	0	0.007835	0	39	119										T	42284440	C	T	42284440	2	4	47	1	0	0	0	0	0	0	0	1	11969	842	30	1		1	PKDCC	2	42284440	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		42284440	200914933	34	13515										
PPM1B	5495	broad.mit.edu	37	chr2	44429053	44429053	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagaagaggatgaatttatcAtcttggcttgtgatgggatc	12	5	2	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:44429053A>G	uc002rtt.2	+	2	1143	c.715A>G	c.(715-717)ATC>GTC	p.I239V	PPM1B_uc002rts.2_Missense_Mutation_p.I239V|PPM1B_uc002rtu.2_Missense_Mutation_p.I239V|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.I239V|PPM1B_uc002rtx.2_Missense_Mutation_p.I239V	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	239					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGAATTTATCATCTTGGCTTG	0.408													0	0	0	0.007835	0	38	61										G	44429053	A	G	44429053	3	3	47	1	0	0	0	0	1	0	0	0	12336	217	8	5	717	5	PPM1B	2	44429053	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	2144613	44429053	198770320	35	13516										
SLC4A5	57835	broad.mit.edu	37	chr2	74474321	74474321	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agaagccctcctcggtgaagCgggtgatatatttgatgata	12	7	0	5			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:74474321C>T	uc002sko.1	-	14	1903	c.1901G>A	c.(1900-1902)CGC>CAC	p.R634H	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.R634H|SLC4A5_uc010ffc.1_Missense_Mutation_p.R634H|SLC4A5_uc002skp.1_Missense_Mutation_p.R570H|SLC4A5_uc002sks.1_Missense_Mutation_p.R634H	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	634	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						CTCGGTGAAGCGGGTGATATA	0.488													0	0	0	0.014323	0	22	190										T	74474321	C	T	74474321	3	4	47	1	0	0	0	0	1	0	0	0	14657	768	27	2	1564	2	SLC4A5	2	74474321	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	30045268	74474321	168725052	36	13517										
MRPL35	51318	broad.mit.edu	37	chr2	86434368	86434368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atctctaacatacttcagtgCaagaaaaggcaagagaaaga	8	7	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:86434368C>T	uc002srg.3	+	3	354	c.296C>T	c.(295-297)GCA>GTA	p.A99V	MRPL35_uc002srf.3_Missense_Mutation_p.A99V	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	99					translation	mitochondrial ribosome	structural constituent of ribosome				0						TACTTCAGTGCAAGAAAAGGC	0.418													0	0	0	0.008291	0	9	60										T	86434368	C	T	86434368	3	4	47	1	0	0	0	0	1	0	0	0	9798	710	25	2	306	2	MRPL35	2	86434368	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	11960047	86434368	156765005	37	13518										
KIAA1310	55683	broad.mit.edu	37	chr2	97268530	97268530	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agggatttgctggaaggccaGaggtcttgctgctgatatcc	14	8	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:97268530G>A	uc002swn.3	-	18	2365	c.2219C>T	c.(2218-2220)TCT>TTT	p.S740F	KIAA1310_uc002swh.3_Missense_Mutation_p.S626F|KIAA1310_uc002swi.3_Missense_Mutation_p.S667F|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.S653F|KIAA1310_uc010fhz.2_Missense_Mutation_p.S560F|KIAA1310_uc002swl.3_Missense_Mutation_p.S639F|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.S534F|KIAA1310_uc002swo.2_Missense_Mutation_p.S88F	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	766	Ser-rich.										0						TGGAAGGCCAGAGGTCTTGCT	0.592													0	0	0	0.00632	0	24	104										A	97268530	G	A	97268530	3	1	47	1	0	0	0	0	1	0	0	0	8222	942	33	1	433	1	KIAA1310	2	97268530	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	10834162	97268530	145930843	38	13519										
MAP4K4	9448	broad.mit.edu	37	chr2	102460640	102460640	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcaggagaacaaggaacgttCcgaggctcttcggagacaac	13	10	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:102460640C>T	uc002tbg.2	+	12	1155	c.1100C>T	c.(1099-1101)TCC>TTC	p.S367F	MAP4K4_uc002tbc.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbd.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbe.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbf.2_Missense_Mutation_p.S367F|MAP4K4_uc010yvy.1_Missense_Mutation_p.S367F|MAP4K4_uc002tbh.2_Missense_Mutation_p.S367F|MAP4K4_uc002tbi.2_Missense_Mutation_p.S220F|MAP4K4_uc010yvz.1_Missense_Mutation_p.S347F|MAP4K4_uc002tbk.2_5'UTR|MAP4K4_uc002tbj.1_Missense_Mutation_p.S263F	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	367					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AAGGAACGTTCCGAGGCTCTT	0.512													0	0	0	0.014758	0	5	28										T	102460640	C	T	102460640	3	4	47	1	0	0	0	0	1	0	0	0	9262	855	30	1	1146	1	MAP4K4	2	102460640	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	5192110	102460640	140738733	39	13520										
ANAPC1	64682	broad.mit.edu	37	chr2	112621282	112621282	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccatgttggaaatagaaggtGagcgagaatgtagactgggt	15	4	0	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:112621282G>A	uc002thi.2	-	9	1269	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	341					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						AATAGAAGGTGAGCGAGAATG	0.428													0	0	0	0.007413	0	17	107										A	112621282	G	A	112621282	3	1	47	1	0	0	0	0	1	0	0	0	598	1294	45	1	4972	1	ANAPC1	2	112621282	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	10160642	112621282	130578091	40	13521										
GPR148	344561	broad.mit.edu	37	chr2	131487541	131487541	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	actcagtgctgatcacattgTacgtgagcacaggggtggtg	14	8	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:131487541T>C	uc002trv.1	+	1	819	c.817T>C	c.(817-819)TAC>CAC	p.Y273H		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	273	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					GATCACATTGTACGTGAGCAC	0.582													0	0	0	0.01441	0	76	75										C	131487541	T	C	131487541	3	2	47	1	0	0	0	0	1	0	0	0	6653	1638	57	5	819	5	GPR148	2	131487541	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	18866259	131487541	111711832	41	13522										
FAM168B	130074	broad.mit.edu	37	chr2	131812980	131812980	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgtggtgtggtggatgacgtGaggaggtgctgcatacagcg	19	6	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:131812980G>A	uc002tsd.2	-	5	569	c.340C>T	c.(340-342)CAC>TAC	p.H114Y		NM_001009993	NP_001009993	A1KXE4	F168B_HUMAN	hypothetical protein LOC130074	114											0						TGGATGACGTGAGGAGGTGCT	0.617													0	0	0	0.01441	0	64	69										A	131812980	G	A	131812980	3	1	47	1	0	0	0	0	1	0	0	0	5486	1290	45	1	255	1	FAM168B	2	131812980	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	325439	131812980	111386393	42	13523										
NCKAP5	344148	broad.mit.edu	37	chr2	133540922	133540922	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgagcagctggggagacttCatgagcactttgagtcccac	12	11	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:133540922C>G	uc002ttp.2	-	14	3836	c.3462G>C	c.(3460-3462)ATG>ATC	p.M1154I	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1154							protein binding				0						GGGGAGACTTCATGAGCACTT	0.488													0	0	0	0.013726	0	34	102										G	133540922	C	G	133540922	3	3	47	1	0	0	0	0	1	0	0	0	10223	826	29	1	2295	1	NCKAP5	2	133540922	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1727942	133540922	109658451	43	13524										
LRP1B	53353	broad.mit.edu	37	chr2	141245258	141245258	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cggctagaatcgatccaataGatgaattcttctctgtaatc	7	9	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:141245258G>C	uc002tvj.1	-	58	10143	c.9171C>G	c.(9169-9171)ATC>ATG	p.I3057M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3057	Extracellular (Potential).|LDL-receptor class B 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGATCCAATAGATGAATTCTT	0.308										TSP Lung(27;0.18)			0	0	0	0.021022	0	38	80										C	141245258	G	C	141245258	3	2	47	1	0	0	0	0	1	0	0	0	8955	932	33	1	4764	1	LRP1B	2	141245258	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	7704336	141245258	101954115	44	13525										
FAP	2191	broad.mit.edu	37	chr2	163075644	163075644	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taaatgttatttgaaaaggtGgatctcctggtctttgtttc	9	5	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:163075644G>A	uc002ucd.2	-	8	744	c.536C>T	c.(535-537)CCA>CTA	p.P179L	FAP_uc010zct.1_Missense_Mutation_p.P154L|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Missense_Mutation_p.P146L	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	179	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TTGAAAAGGTGGATCTCCTGG	0.328													0	0	0	0.01441	0	84	90										A	163075644	G	A	163075644	3	1	47	1	0	0	0	0	1	0	0	0	5673	1348	47	2	1822	2	FAP	2	163075644	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	21830386	163075644	80123729	45	13526										
IFIH1	64135	broad.mit.edu	37	chr2	163144789	163144789	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcttcccttccaaggctggCtgggcaacttccatttggta	9	12	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:163144789C>G	uc002uce.2	-	5	1173	c.951G>C	c.(949-951)CAG>CAC	p.Q317H		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	317	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						CCAAGGCTGGCTGGGCAACTT	0.478													0	0	0	0.012213	0	33	86										G	163144789	C	G	163144789	3	3	47	1	0	0	0	0	1	0	0	0	7520	796	28	4	2174	4	IFIH1	2	163144789	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	69145	163144789	80054584	46	13527										
CHN1	1123	broad.mit.edu	37	chr2	175664879	175664879	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcgtttttgataagcagctCcaccaccagtctctgatacc	6	13	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:175664879C>G	uc002uji.2	-	13	1875	c.1345G>C	c.(1345-1347)GAG>CAG	p.E449Q	CHN1_uc010zeq.1_Missense_Mutation_p.E423Q|CHN1_uc002ujj.2_Missense_Mutation_p.E224Q|CHN1_uc002ujg.2_Missense_Mutation_p.E324Q	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	449	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			ATAAGCAGCTCCACCACCAGT	0.358			T	TAF15	extraskeletal myxoid chondrosarcoma								0	0	0	0.006122	0	18	25										G	175664879	C	G	175664879	3	3	47	1	0	0	0	0	1	0	0	0	3362	864	30	1	38	1	CHN1	2	175664879	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	12520090	175664879	67534494	47	13528										
TTN	7273	broad.mit.edu	37	chr2	179412163	179412163	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gttcagcaattattggtgctGattctagaggtttgctgaca	11	6	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:179412163G>A	uc010zfg.1	-	288	86710	c.86486C>T	c.(86485-86487)TCA>TTA	p.S28829L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S22524L|TTN_uc010zfi.1_Missense_Mutation_p.S22457L|TTN_uc010zfj.1_Missense_Mutation_p.S22332L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29756							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTGGTGCTGATTCTAGAGG	0.323													0	0	0	0.001168	0	6	23										A	179412163	G	A	179412163	3	1	47	1	0	0	0	0	1	0	0	0	16732	1294	45	1	13885	1	TTN	2	179412163	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	3747284	179412163	63787210	48	13529										
TTN	7273	broad.mit.edu	37	chr2	179462655	179462655	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	caagtctgtccttcatttcaAtgacatctgtgacctctcca	5	13	5	2	rs78509062		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:179462655A>G	uc010zfg.1	-	242	49762	c.49538T>C	c.(49537-49539)ATT>ACT	p.I16513T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I10208T|TTN_uc010zfi.1_Missense_Mutation_p.I10141T|TTN_uc010zfj.1_Missense_Mutation_p.I10016T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17440							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCATTTCAATGACATCTGT	0.368													0	0	0	0.01441	0	50	92										G	179462655	A	G	179462655	3	3	47	1	0	0	0	0	1	0	0	0	16732	101	4	5	50731	5	TTN	2	179462655	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	50492	179462655	63736718	49	13530										
STAT1	6772	broad.mit.edu	37	chr2	191847160	191847160	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtccacattgagacctctttTggtgacagaagaaaactgcc	9	10	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:191847160T>C	uc002usj.2	-	18	1919	c.1531A>G	c.(1531-1533)AAA>GAA	p.K511E	STAT1_uc010fse.1_Missense_Mutation_p.K511E|STAT1_uc002usk.2_Missense_Mutation_p.K511E|STAT1_uc002usl.2_Missense_Mutation_p.K513E|STAT1_uc010fsf.1_Missense_Mutation_p.K323E	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	511					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AGACCTCTTTTGGTGACAGAA	0.403													0	0	0	0.01441	0	96	115										C	191847160	T	C	191847160	3	2	47	1	0	0	0	0	1	0	0	0	15263	1821	63	5	757	5	STAT1	2	191847160	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	12384505	191847160	51352213	50	13531										
C2orf60	129450	broad.mit.edu	37	chr2	200800710	200800710	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	attcatatcttctagccttgGaaaaaagtggatatttagcc	7	7	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:200800710G>C	uc002uvi.3	-	7	901	c.635C>G	c.(634-636)TCC>TGC	p.S212C	C2orf60_uc002uvj.3_Missense_Mutation_p.S49C|C2orf60_uc002uvk.3_RNA|C2orf60_uc010fss.2_Missense_Mutation_p.S49C	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	212	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						TCTAGCCTTGGAAAAAAGTGG	0.333													0	0	0	0.007835	0	43	163										C	200800710	G	C	200800710	3	2	47	1	0	0	0	0	1	0	0	0	2179	1174	41	1	320	1	C2orf60	2	200800710	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	8953550	200800710	42398663	51	13532										
MYL1	4632	broad.mit.edu	37	chr2	211158490	211158490	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gagtcttcttgacctgccatCagggcttccacttcttcctc	7	15	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:211158490C>T	uc002vec.2	-	5	642	c.513G>A	c.(511-513)CTG>CTA	p.L171L	MYL1_uc002veb.2_Silent_p.L127L	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	171	EF-hand 3.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GACCTGCCATCAGGGCTTCCA	0.423													0	0	0	0.01441	0	56	243										T	211158490	C	T	211158490	2	4	47	1	0	0	0	0	0	0	0	1	10043	813	29	1		1	MYL1	2	211158490	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	10357780	211158490	32040883	52	13533										
CPS1	1373	broad.mit.edu	37	chr2	211525295	211525295	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcattgatgtggccaccaaGgtgatgattggagagaatgt	13	5	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:211525295G>A	uc002vee.3	+	32	3975	c.3843G>A	c.(3841-3843)AAG>AAA	p.K1281K	CPS1_uc010fur.2_Silent_p.K1287K|CPS1_uc010fus.2_Silent_p.K830K	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1281	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGGCCACCAAGGTGATGATTG	0.403													0	0	0	0.01441	0	87	221										A	211525295	G	A	211525295	2	1	47	1	0	0	0	0	0	0	0	1	3823	991	35	2		2	CPS1	2	211525295	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	366805	211525295	31674078	53	13534										
ERBB4	2066	broad.mit.edu	37	chr2	212522499	212522499	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctagcatgttgtggtaaagtGgaatggcccgtccatgggta	14	7	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:212522499G>A	uc002veg.1	-	16	2024	c.1926C>T	c.(1924-1926)TCC>TCT	p.S642S	ERBB4_uc002veh.1_Silent_p.S642S|ERBB4_uc010zji.1_Intron|ERBB4_uc010zjj.1_Intron|ERBB4_uc010fut.1_Silent_p.S642S	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	642	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTGGTAAAGTGGAATGGCCCG	0.428										TSP Lung(8;0.080)			0	0	0	0.01441	0	45	57										A	212522499	G	A	212522499	2	1	47	1	0	0	0	0	0	0	0	1	5209	1335	47	2		2	ERBB4	2	212522499	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	997204	212522499	30676874	54	13535										
ARMC9	80210	broad.mit.edu	37	chr2	232156134	232156134	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atgatccgccagatagaattCatcatcaagcagctaaattc	6	10	3	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:232156134C>T	uc002vrq.3	+	18	1807	c.1695C>T	c.(1693-1695)TTC>TTT	p.F565F	ARMC9_uc002vrp.3_Silent_p.F565F|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	565							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		AGATAGAATTCATCATCAAGC	0.378													0	0	0	0.01441	0	46	88										T	232156134	C	T	232156134	2	4	47	1	0	0	0	0	0	0	0	1	958	825	29	1		1	ARMC9	2	232156134	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	19633635	232156134	11043239	55	13536										
DIS3L2	129563	broad.mit.edu	37	chr2	232995343	232995343	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atgtaggaagagaggatggtGatgcaccggttacaaaagat	14	4	0	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr2:232995343G>A	uc010fxz.2	+	7	892	c.616G>A	c.(616-618)GAT>AAT	p.D206N	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vsn.1_Missense_Mutation_p.D206N|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	206							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		AGAGGATGGTGATGCACCGGT	0.393													0	0	0	0.010504	0	20	32										A	232995343	G	A	232995343	3	1	47	1	0	0	0	0	1	0	0	0	4537	1290	45	1	638	1	DIS3L2	2	232995343	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	839209	232995343	10204030	56	13537										
BRPF1	7862	broad.mit.edu	37	chr3	9786008	9786008	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagacagctggaccgcccaaGaggccgggccggccccccaa	13	17	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:9786008G>T	uc003bse.2	+	9	3117	c.2718G>T	c.(2716-2718)AAG>AAT	p.K906N	BRPF1_uc003bsf.2_Missense_Mutation_p.K912N|BRPF1_uc003bsg.2_Missense_Mutation_p.K905N|BRPF1_uc011ati.1_Intron	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	906	Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GACCGCCCAAGAGGCCGGGCC	0.647													1	0	3.09479e-21	0.006999	3.38557e-21	39	72										T	9786008	G	T	9786008	3	4	47	1	0	0	0	0	1	0	0	0	1520	933	33	3	2766	3	BRPF1	3	9786008	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		9786008	188236422	57	13538										
ENTPD3	956	broad.mit.edu	37	chr3	40464569	40464569	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gccatgatcaagaaacctgtTcttttgatggggtttatcag	10	7	3	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:40464569T>A	uc003ckd.3	+	8	1152	c.1060T>A	c.(1060-1062)TCT>ACT	p.S354T	ENTPD3_uc010hhy.2_Missense_Mutation_p.S354T|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	354	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		AGAAACCTGTTCTTTTGATGG	0.408													0	0	0	0.01441	0	82	105										A	40464569	T	A	40464569	3	1	47	1	0	0	0	0	1	0	0	0	5140	1783	62	5	1086	5	ENTPD3	3	40464569	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	30678561	40464569	157557861	58	13539										
ULK4	54986	broad.mit.edu	37	chr3	41841697	41841697	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acaaaatgggtcctatttctCctgtaataaagccctgggac	8	10	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:41841697C>T	uc003ckv.3	-	20	2138	c.1937G>A	c.(1936-1938)GGA>GAA	p.G646E	ULK4_uc003ckw.2_Missense_Mutation_p.G646E	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	646							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TCCTATTTCTCCTGTAATAAA	0.418													0	0	0	0.01441	0	109	176										T	41841697	C	T	41841697	3	4	47	1	0	0	0	0	1	0	0	0	16975	855	30	1	1962	1	ULK4	3	41841697	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1377128	41841697	156180733	59	13540										
NKTR	4820	broad.mit.edu	37	chr3	42678913	42678913	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	caccaagaaaaacagcttctCagttaagtgaaaataaacca	5	9	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:42678913C>T	uc003clo.2	+	13	1864	c.1717C>T	c.(1717-1719)CAG>TAG	p.Q573*	NKTR_uc003clm.1_Nonsense_Mutation_p.Q320*|NKTR_uc003clp.2_Nonsense_Mutation_p.Q320*|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Nonsense_Mutation_p.Q463*|NKTR_uc003clr.1_Nonsense_Mutation_p.Q320*|NKTR_uc003cls.2_Nonsense_Mutation_p.Q273*	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	573	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AACAGCTTCTCAGTTAAGTGA	0.378													0	0	0	0.01441	0	53	184										T	42678913	C	T	42678913	4	4	47	1	0	0	0	0	0	1	0	0	10448	827	29	1	1763	1	NKTR	3	42678913	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	837216	42678913	155343517	60	13541										
ZNF167	55888	broad.mit.edu	37	chr3	44612062	44612062	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccgactcactgaccaccagaGaacccatactggggagaaac	9	14	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:44612062G>C	uc010hin.2	+	6	1848	c.1460G>C	c.(1459-1461)AGA>ACA	p.R487T	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Missense_Mutation_p.R336T|ZNF167_uc003cnj.2_Missense_Mutation_p.R487T|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	487	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GACCACCAGAGAACCCATACT	0.458													0	0	0	0.009718	0	40	164										C	44612062	G	C	44612062	3	2	47	1	0	0	0	0	1	0	0	0	17738	942	33	1	1478	1	ZNF167	3	44612062	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1933149	44612062	153410368	61	13542										
ZNF197	10168	broad.mit.edu	37	chr3	44674010	44674010	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagtatgcttcacttcagagGaatgggcatgtctgggccca	12	10	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:44674010G>A	uc003cnm.2	+	5	894	c.688G>A	c.(688-690)GAA>AAA	p.E230K	ZNF197_uc003cnn.2_Missense_Mutation_p.E230K|ZNF197_uc003cno.2_RNA|ZNF197_uc003cnp.2_Missense_Mutation_p.E230K	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	230	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		CACTTCAGAGGAATGGGCATG	0.473													0	0	0	0.016723	0	12	368										A	44674010	G	A	44674010	3	1	47	1	0	0	0	0	1	0	0	0	17756	1175	41	1	702	1	ZNF197	3	44674010	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	61948	44674010	153348420	62	13543										
TGM4	7047	broad.mit.edu	37	chr3	44945406	44945406	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtgtggacggatgcctggatGaagcgaccggatctgcccaa	15	10	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:44945406G>A	uc003coc.3	+	9	1075	c.1002G>A	c.(1000-1002)ATG>ATA	p.M334I		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	334					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATGCCTGGATGAAGCGACCGG	0.617													0	0	0	0.015359	0	30	70										A	44945406	G	A	44945406	3	1	47	1	0	0	0	0	1	0	0	0	15829	1290	45	1	1036	1	TGM4	3	44945406	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	271396	44945406	153077024	63	13544										
FYCO1	79443	broad.mit.edu	37	chr3	46006596	46006596	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctcaagctggcccctgaggcTcttgcactcttcaccagcat	8	16	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:46006596T>A	uc003cpb.3	-	9	3285	c.3079A>T	c.(3079-3081)AGC>TGC	p.S1027C	FYCO1_uc011bal.1_Missense_Mutation_p.S1027C	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	1027	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CCCCTGAGGCTCTTGCACTCT	0.562													0	0	0	0.021523	0	25	67										A	46006596	T	A	46006596	3	1	47	1	0	0	0	0	1	0	0	0	6125	1551	54	5	1397	5	FYCO1	3	46006596	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	1061190	46006596	152015834	64	13545										
KIAA2018	205717	broad.mit.edu	37	chr3	113380114	113380114	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttttgaacctggtcactagGaataacaacagagacctttg	8	8	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:113380114G>A	uc003eam.2	-	7	826	c.415C>T	c.(415-417)CCT>TCT	p.P139S	KIAA2018_uc003eal.2_Missense_Mutation_p.P83S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	139					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TGGTCACTAGGAATAACAACA	0.363													0	0	0	0.00308	0	8	208										A	113380114	G	A	113380114	3	1	47	1	0	0	0	0	1	0	0	0	8268	1174	41	1	6326	1	KIAA2018	3	113380114	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	67373518	113380114	84642316	65	13546										
SR140	23350	broad.mit.edu	37	chr3	142747454	142747454	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagaaacagaagcttttgtaGaggaacctagtaaaaaggga	11	4	0	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:142747454G>C	uc003evh.1	+	16	1675	c.1576G>C	c.(1576-1578)GAG>CAG	p.E526Q	SR140_uc003evi.1_Missense_Mutation_p.E117Q|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.E525Q|SR140_uc003evl.1_Missense_Mutation_p.E93Q	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	526					RNA processing	nucleus	nucleotide binding|RNA binding				0						AGCTTTTGTAGAGGAACCTAG	0.343													0	0	0	0.010818	0	29	80										C	142747454	G	C	142747454	3	2	47	1	0	0	0	0	1	0	0	0	15130	943	33	1	1638	1	SR140	3	142747454	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	29367340	142747454	55274976	66	13547										
PLOD2	5352	broad.mit.edu	37	chr3	145806415	145806415	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agtgcttcttttgggtaatcCagtgtcaacaatatgtccag	9	8	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:145806415C>T	uc003evs.1	-	9	1469	c.963G>A	c.(961-963)CTG>CTA	p.L321L	PLOD2_uc003evq.1_5'Flank|PLOD2_uc011bnm.1_Silent_p.L266L|PLOD2_uc003evr.1_Silent_p.L321L	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	321					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TTGGGTAATCCAGTGTCAACA	0.323													0	0	0	0.00632	0	27	56										T	145806415	C	T	145806415	2	4	47	1	0	0	0	0	0	0	0	1	12102	581	21	2		2	PLOD2	3	145806415	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	3058961	145806415	52216015	67	13548										
P2RY1	5028	broad.mit.edu	37	chr3	152554107	152554107	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgtgctggtgtggctcattgTggtggtggcgatctccccca	15	11	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:152554107T>C	uc003ezq.2	+	1	1372	c.536T>C	c.(535-537)GTG>GCG	p.V179A		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	179	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGGCTCATTGTGGTGGTGGCG	0.567													0	0	0	0.005524	0	36	52										C	152554107	T	C	152554107	3	2	47	1	0	0	0	0	1	0	0	0	11346	1696	59	5	538	5	P2RY1	3	152554107	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	6747692	152554107	45468323	68	13549										
SEC62	7095	broad.mit.edu	37	chr3	169706098	169706098	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agagtaggtgtttattacctCagtgtgggtgcaggctgttt	14	5	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:169706098C>T	uc003fgg.2	+	7	712	c.681C>T	c.(679-681)CTC>CTT	p.L227L	SEC62_uc003fgh.2_Silent_p.L227L	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	227	Lumenal (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						TTTATTACCTCAGTGTGGGTG	0.413													0	0	0	0.01441	0	60	216										T	169706098	C	T	169706098	2	4	47	1	0	0	0	0	0	0	0	1	14004	813	29	1		1	SEC62	3	169706098	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	17151991	169706098	28316332	69	13550										
CCDC50	152137	broad.mit.edu	37	chr3	191047481	191047481	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggtatggctgaagtcagcatCgaccagtccaagctgcctgg	13	11	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr3:191047481C>G	uc003fsw.2	+	1	608	c.18C>G	c.(16-18)ATC>ATG	p.I6M	CCDC50_uc003fsv.2_Missense_Mutation_p.I6M|UTS2D_uc003fsu.2_Intron	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	6						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		AAGTCAGCATCGACCAGTCCA	0.701													0	0	0	0.001168	0	4	4										G	191047481	C	G	191047481	3	3	47	1	0	0	0	0	1	0	0	0	2820	874	31	1	20	1	CCDC50	3	191047481	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	21341383	191047481	6974949	70	13551										
TACC3	10460	broad.mit.edu	37	chr4	1725159	1725159	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttttccagaatgagtctgcAggtcttaaacgacaaaaatg	8	8	2	2	rs145470576	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:1725159A>G	uc003gdo.2	+	2	119	c.11A>G	c.(10-12)CAG>CGG	p.Q4R	TMEM129_uc003gdn.2_5'Flank|TMEM129_uc003gdm.2_5'Flank|TACC3_uc010ibz.2_Missense_Mutation_p.Q4R|TACC3_uc003gdp.2_Missense_Mutation_p.Q4R	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	4						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			ATGAGTCTGCAGGTCTTAAAC	0.458													0	0	0	0.004672	0	3	35										G	1725159	A	G	1725159	3	3	47	1	0	0	0	0	1	0	0	0	15500	188	7	5	13	5	TACC3	4	1725159	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08		1725159	189429117	71	13552										
EVC	2121	broad.mit.edu	37	chr4	5733227	5733227	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttttgccacaccagccggtaGaggcctctccttccagcagt	9	15	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:5733227G>C	uc003gil.1	+	4	644	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	EVC_uc003gim.1_RNA	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	154					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CCAGCCGGTAGAGGCCTCTCC	0.602													0	0	0	0.017118	0	19	27										C	5733227	G	C	5733227	3	2	47	1	0	0	0	0	1	0	0	0	5285	943	33	1	474	1	EVC	4	5733227	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	4008068	5733227	185421049	72	13553										
BOD1L	259282	broad.mit.edu	37	chr4	13601779	13601779	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gatgccactcccgtctttttCttccatgactgtgccagctc	7	15	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:13601779C>G	uc003gmz.1	-	10	6862	c.6745G>C	c.(6745-6747)GAA>CAA	p.E2249Q	BOD1L_uc010idr.1_Missense_Mutation_p.E1586Q	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2249							DNA binding			ovary(5)|breast(1)	6						CCGTCTTTTTCTTCCATGACT	0.517													0	0	0	0.014323	0	22	6										G	13601779	C	G	13601779	3	3	47	1	0	0	0	0	1	0	0	0	1483	922	32	1	2478	1	BOD1L	4	13601779	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7868552	13601779	177552497	73	13554										
RBM47	54502	broad.mit.edu	37	chr4	40434800	40434800	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atcatgtgctccactgtgtgGattttgccatcttcaatcat	7	10	4	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:40434800G>C	uc003gvc.2	-	6	2120	c.1410C>G	c.(1408-1410)ATC>ATG	p.I470M	RBM47_uc003gvd.2_Missense_Mutation_p.I401M|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.I432M	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	470						nucleus	nucleotide binding|RNA binding			breast(3)	3						CCACTGTGTGGATTTTGCCAT	0.413													0	0	0	0.010729	0	11	18										C	40434800	G	C	40434800	3	2	47	1	0	0	0	0	1	0	0	0	13141	1164	41	1	379	1	RBM47	4	40434800	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	26833021	40434800	150719476	74	13555										
CLOCK	9575	broad.mit.edu	37	chr4	56336930	56336930	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cactctcagacacatatattAtgcttccatctgtcatgatt	4	11	3	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:56336930A>G	uc003haz.1	-	9	1318	c.392T>C	c.(391-393)ATA>ACA	p.I131T	CLOCK_uc003hba.1_Missense_Mutation_p.I131T	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	131	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CACATATATTATGCTTCCATC	0.284													0	0	0	0.01441	0	52	151										G	56336930	A	G	56336930	3	3	47	1	0	0	0	0	1	0	0	0	3549	449	16	5	2212	5	CLOCK	4	56336930	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	15902130	56336930	134817346	75	13556										
ADAMTS3	9508	broad.mit.edu	37	chr4	73414511	73414511	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgacctctttttgtgactcGcagaaagagtatgggagaga	12	7	1	5	rs145300703		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:73414511G>A	uc003hgk.1	-	3	225	c.188C>T	c.(187-189)GCG>GTG	p.A63V		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	63					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTTGTGACTCGCAGAAAGAGT	0.448													0	0	0	0.014323	0	23	67										A	73414511	G	A	73414511	3	1	47	1	0	0	0	0	1	0	0	0	267	1087	38	2	3509	2	ADAMTS3	4	73414511	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	17077581	73414511	117739765	76	13557										
CXCL6	6372	broad.mit.edu	37	chr4	74702788	74702788	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgcaggtgttccccgcaggcCcgcagtgctccaaggtggaa	14	13	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:74702788C>G	uc003hhf.2	+	2	412	c.217C>G	c.(217-219)CCG>GCG	p.P73A	IL8_uc011cbh.1_Intron	NM_002993	NP_002984	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6 (granulocyte	73					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CCCCGCAGGCCCGCAGTGCTC	0.542													0	0	0	0.010729	0	12	56										G	74702788	C	G	74702788	3	3	47	1	0	0	0	0	1	0	0	0	4088	623	22	4	223	4	CXCL6	4	74702788	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1288277	74702788	116451488	77	13558										
HNRPDL	9987	broad.mit.edu	37	chr4	83349206	83349206	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aaaatattctttaatttgttCttcagaagtatccgggctca	6	7	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:83349206C>T	uc003hmr.2	-	3	1274	c.739G>A	c.(739-741)GAA>AAA	p.E247K	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.E247K	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	247	RRM 2.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				TTAATTTGTTCTTCAGAAGTA	0.383													0	0	0	0.00632	0	27	88										T	83349206	C	T	83349206	3	4	47	1	0	0	0	0	1	0	0	0	7276	922	32	1	543	1	HNRPDL	4	83349206	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	8646418	83349206	107805070	78	13559										
PDHA2	5161	broad.mit.edu	37	chr4	96761377	96761377	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcagagtgctggtggcatccCgtaactcctcaaatgacgct	11	12	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:96761377C>A	uc003htr.3	+	1	139	c.76C>A	c.(76-78)CGT>AGT	p.R26S		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	26					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GGTGGCATCCCGTAACTCCTC	0.522													1	0	0.000442599	0.006214	0.000450898	10	23										A	96761377	C	A	96761377	3	1	47	1	0	0	0	0	1	0	0	0	11665	652	23	4	78	4	PDHA2	4	96761377	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	13412171	96761377	94392899	79	13560										
LRIT3	345193	broad.mit.edu	37	chr4	110788968	110788968	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	attggagcattgtctgaaacCatcagtgatgacctcagcca	9	10	3	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:110788968C>T	uc003hzx.3	+	2	819	c.626C>T	c.(625-627)CCA>CTA	p.P209L	LRIT3_uc003hzw.3_Missense_Mutation_p.P71L	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	209	Ig-like.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TGTCTGAAACCATCAGTGATG	0.512													0	0	0	0.017118	0	37	43										T	110788968	C	T	110788968	3	4	47	1	0	0	0	0	1	0	0	0	8949	594	21	2	632	2	LRIT3	4	110788968	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	14027591	110788968	80365308	80	13561										
SYNPO2	171024	broad.mit.edu	37	chr4	119952786	119952786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagccctccaaaatgggcaaGaaaaagggaaagaaacccct	9	11	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:119952786G>C	uc003icm.3	+	4	3052	c.2856G>C	c.(2854-2856)AAG>AAC	p.K952N	SYNPO2_uc010ina.2_Missense_Mutation_p.K952N|SYNPO2_uc010inb.2_Missense_Mutation_p.K952N|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.K880N	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	952						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AAATGGGCAAGAAAAAGGGAA	0.498													0	0	0	0.004482	0	8	40										C	119952786	G	C	119952786	3	2	47	1	0	0	0	0	1	0	0	0	15454	933	33	1	2870	1	SYNPO2	4	119952786	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	9163818	119952786	71201490	81	13562										
ANXA5	308	broad.mit.edu	37	chr4	122590871	122590871	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atgagggtatgatcatctgtCccagctccctttaaaaaaaa	7	9	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:122590871C>T	uc003idu.3	-	11	859	c.789G>A	c.(787-789)GGG>GGA	p.G263G	ANXA5_uc003idv.3_Silent_p.G263G|ANXA5_uc003idw.3_RNA|ANXA5_uc010inm.2_Intron|ANXA5_uc010inn.2_Silent_p.G203G|ANXA5_uc010ino.2_Silent_p.G163G	NM_001154	NP_001145	P08758	ANXA5_HUMAN	annexin 5	263	Annexin 4.				anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			ovary(1)	1						GATCATCTGTCCCAGCTCCCT	0.393													0	0	0	0.021523	0	26	53										T	122590871	C	T	122590871	2	4	47	1	0	0	0	0	0	0	0	1	721	842	30	1		1	ANXA5	4	122590871	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2638085	122590871	68563405	82	13563										
FAT4	79633	broad.mit.edu	37	chr4	126369781	126369781	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agcttcagaagtgacattttCtgtgcatgtaaaagatggtg	11	5	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:126369781C>T	uc003ifj.3	+	9	7610	c.7610C>T	c.(7609-7611)TCT>TTT	p.S2537F	FAT4_uc011cgp.1_Missense_Mutation_p.S835F|FAT4_uc003ifi.1_Missense_Mutation_p.S15F	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2537	Extracellular (Potential).|Cadherin 24.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTGACATTTTCTGTGCATGTA	0.438													0	0	0	0.00499	0	18	45										T	126369781	C	T	126369781	3	4	47	1	0	0	0	0	1	0	0	0	5692	913	32	1	7644	1	FAT4	4	126369781	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	3778910	126369781	64784495	83	13564										
FAT4	79633	broad.mit.edu	37	chr4	126411829	126411829	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	catctccagagcaggagataGagcactatgacattgacaac	9	10	1	5			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:126411829G>T	uc003ifj.3	+	17	13852	c.13852G>T	c.(13852-13854)GAG>TAG	p.E4618*	FAT4_uc011cgp.1_Nonsense_Mutation_p.E2859*|FAT4_uc003ifi.1_Nonsense_Mutation_p.E2095*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4618	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCAGGAGATAGAGCACTATGA	0.478													1	0	1.37522e-17	0.007413	1.48451e-17	18	37										T	126411829	G	T	126411829	4	4	47	1	0	0	0	0	0	1	0	0	5692	943	33	3	13918	3	FAT4	4	126411829	Nonsense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	42048	126411829	64742447	84	13565										
OTUD4	54726	broad.mit.edu	37	chr4	146067508	146067508	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttgcttctctctgcgctcttCtggggaaaggccgaaatagt	11	10	4	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:146067508C>T	uc003ika.3	-	14	1276	c.1138G>A	c.(1138-1140)GAA>AAA	p.E380K	OTUD4_uc003ijz.3_Missense_Mutation_p.E379K	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	444							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CTGCGCTCTTCTGGGGAAAGG	0.413													0	0	0	0.00308	0	7	123										T	146067508	C	T	146067508	3	4	47	1	0	0	0	0	1	0	0	0	11314	922	32	1	2043	1	OTUD4	4	146067508	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	19655679	146067508	45086768	85	13566										
PALLD	23022	broad.mit.edu	37	chr4	169602510	169602510	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcaacagattctgacagtgAaagtttagctttcaaatcaa	6	7	4	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:169602510A>C	uc011cjx.1	+	4	1326	c.1115A>C	c.(1114-1116)GAA>GCA	p.E372A	PALLD_uc003iru.2_Missense_Mutation_p.E372A|PALLD_uc003irv.2_5'UTR	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	372					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TCTGACAGTGAAAGTTTAGCT	0.358									Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.014758	0	5	69										C	169602510	A	C	169602510	3	2	47	1	0	0	0	0	1	0	0	0	11407	246	9	5	1125	5	PALLD	4	169602510	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	23535002	169602510	21551766	86	13567										
UFSP2	55325	broad.mit.edu	37	chr4	186329155	186329156	+	Frame_Shift_Ins	INS	-	-	TG													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccagctgcacctcaatagatINSccaatccattgccgcgatcc							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr4:186329155_186329156insTG	uc003ixo.2	-	9	1172_1173	c.1055_1056insCA	c.(1054-1056)GGAfs	p.G352fs	UFSP2_uc003ixn.2_Frame_Shift_Ins_p.G227fs|UFSP2_uc003ixq.2_Frame_Shift_Ins_p.G242fs|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	352						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		CCTCAATAGATCCAATCCATTG	0.391																		23	45	---	---								TG	186329156	-	TG	186329155	7	5	47	1	0	1	1	0	0	0	0	0	16935	1422	50	0	369	0	UFSP2	4	186329155	Frame_Shift_Ins	INS	-	TCGA-DK-A1AD-01A-11D-A13W-08	16726645	186329155	4825121	87	13568										
ADCY2	108	broad.mit.edu	37	chr5	7521004	7521004	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgggaggcaaggagcacctgGtctggcaggtgggtgcacct	18	10	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:7521004G>T	uc003jdz.1	+	3	629	c.562G>T	c.(562-564)GTC>TTC	p.V188F		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	188	Helical; (Potential).			VWQILANVIIFICGNLAGAY -> GLADPGQCDHFHLWEPG XTN (in Ref. 1; AAP97285).	activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGAGCACCTGGTCTGGCAGGT	0.607													1	0	2.74695e-27	0.01441	3.05634e-27	49	75										T	7521004	G	T	7521004	3	4	47	1	0	0	0	0	1	0	0	0	294	1261	44	4	572	4	ADCY2	5	7521004	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		7521004	173394256	88	13569										
SLC45A2	51151	broad.mit.edu	37	chr5	33964006	33964006	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgaacagtaaaacacaaagtGagcaccaatgcagagaagaa	9	7	0	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:33964006G>A	uc003jid.2	-	3	770	c.678C>T	c.(676-678)CTC>CTT	p.L226L	SLC45A2_uc003jie.2_Silent_p.L226L|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	226	Helical; Name=6; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane		p.L226L(1)		ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AACACAAAGTGAGCACCAATG	0.502													0	0	0	0.008871	0	21	107										A	33964006	G	A	33964006	2	1	47	1	0	0	0	0	0	0	0	1	14641	1277	45	1		1	SLC45A2	5	33964006	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	26443002	33964006	146951254	89	13570										
SNX18	112574	broad.mit.edu	37	chr5	53839070	53839070	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gaagggaagatggaggtgcaGaaggctgacggcattcagga	18	5	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:53839070G>A	uc003jpi.3	+	2	1873	c.1683G>A	c.(1681-1683)CAG>CAA	p.Q561Q	SNX18_uc011cqg.1_3'UTR	NM_001102575	NP_001096045	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform a	Error:Variant_position_missing_in_Q96RF0_after_alignment					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TGGAGGTGCAGAAGGCTGACG	0.408													0	0	0	0.008361	0	29	64										A	53839070	G	A	53839070	2	1	47	1	0	0	0	0	0	0	0	1	14889	933	33	1		1	SNX18	5	53839070	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	19875064	53839070	127076190	90	13571										
TMEM171	134285	broad.mit.edu	37	chr5	72419557	72419557	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttatctttgggtttctgttCttgacaagcggcatgctcat	9	9	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:72419557C>T	uc003kcm.2	+	2	561	c.357C>T	c.(355-357)TTC>TTT	p.F119F	TMEM171_uc003kcn.3_Silent_p.F119F	NM_173490	NP_775761	Q8WVE6	TM171_HUMAN	transmembrane protein 171 isoform 1	119	Helical; (Potential).					integral to membrane					0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		GGTTTCTGTTCTTGACAAGCG	0.587													0	0	0	0.008361	0	28	71										T	72419557	C	T	72419557	2	4	47	1	0	0	0	0	0	0	0	1	16085	912	32	1		1	TMEM171	5	72419557	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	18580487	72419557	108495703	91	13572										
HOMER1	9456	broad.mit.edu	37	chr5	78671855	78671855	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gctgcattctagtagcttggCcaagttatctcgtaattctg	9	9	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:78671855C>T	uc003kfy.2	-	9	2145	c.1042G>A	c.(1042-1044)GCC>ACC	p.A348T	HOMER1_uc010jab.2_3'UTR|HOMER1_uc010jac.2_Missense_Mutation_p.A218T|HOMER1_uc010jad.2_Missense_Mutation_p.A174T	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	348	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		AGTAGCTTGGCCAAGTTATCT	0.363													0	0	0	0.013537	0	13	49										T	78671855	C	T	78671855	3	4	47	1	0	0	0	0	1	0	0	0	7278	739	26	2	26	2	HOMER1	5	78671855	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	6252298	78671855	102243405	92	13573										
TRIM36	55521	broad.mit.edu	37	chr5	114466549	114466549	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcagcaggaggtgttcattAttatagccacatttttcatc	7	8	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:114466549A>G	uc003kqs.2	-	9	2081	c.1572T>C	c.(1570-1572)AAT>AAC	p.N524N	TRIM36_uc011cwc.1_Silent_p.N512N|TRIM36_uc003kqt.2_Silent_p.N369N	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	524	B30.2/SPRY.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		GGTGTTCATTATTATAGCCAC	0.368													0	0	0	0.010818	0	31	59										G	114466549	A	G	114466549	2	3	47	1	0	0	0	0	0	0	0	1	16507	446	16	5		5	TRIM36	5	114466549	Silent	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	35794694	114466549	66448711	93	13574										
SLC27A6	28965	broad.mit.edu	37	chr5	128320834	128320834	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttggcttttagatttgcttGgaacggtagaagaaatcctt	10	5	0	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:128320834G>C	uc003kuy.2	+	3	886	c.490G>C	c.(490-492)GGA>CGA	p.G164R	SLC27A6_uc003kuz.2_Missense_Mutation_p.G164R	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	164					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		AGATTTGCTTGGAACGGTAGA	0.373													0	0	0	0.008291	0	10	21										C	128320834	G	C	128320834	3	2	47	1	0	0	0	0	1	0	0	0	14530	1349	47	4	496	4	SLC27A6	5	128320834	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	13854285	128320834	52594426	94	13575										
H2AFY	9555	broad.mit.edu	37	chr5	134679035	134679035	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtttttcactgtcttttccaGaagttcttcacacttgtctg	6	10	5	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:134679035G>C	uc003lam.1	-	8	1078	c.868C>G	c.(868-870)CTG>GTG	p.L290V	uc003laj.1_RNA|H2AFY_uc003lal.1_RNA|H2AFY_uc003lao.1_Missense_Mutation_p.L289V|H2AFY_uc003lan.1_Missense_Mutation_p.L287V|H2AFY_uc003lap.1_RNA|H2AFY_uc003laq.1_RNA|H2AFY_uc003lar.1_RNA|H2AFY_uc011cxz.1_Missense_Mutation_p.L118V|H2AFY_uc003las.1_Missense_Mutation_p.L290V|H2AFY_uc003lat.1_Missense_Mutation_p.L289V	NM_138610	NP_613258	O75367	H2AY_HUMAN	H2A histone family, member Y isoform 3	290	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTCTTTTCCAGAAGTTCTTCA	0.522													0	0	0	0.00874	0	44	122										C	134679035	G	C	134679035	3	2	47	1	0	0	0	0	1	0	0	0	6929	933	33	1	258	1	H2AFY	5	134679035	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	6358201	134679035	46236225	95	13576										
LECT2	3950	broad.mit.edu	37	chr5	135283149	135283149	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcttaataggacctttataCttaattggcttaatgtagaa	6	5	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:135283149C>G	uc003lbe.1	-	4	528	c.327G>C	c.(325-327)AAG>AAC	p.K109N	FBXL21_uc003lbc.2_Intron	NM_002302	NP_002293	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2 precursor	109					chemotaxis|skeletal system development	cytoplasm|extracellular space				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GACCTTTATACTTAATTGGCT	0.299													0	0	0	0.012213	0	34	45										G	135283149	C	G	135283149	3	3	47	1	0	0	0	0	1	0	0	0	8713	564	20	4	132	4	LECT2	5	135283149	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	604114	135283149	45632111	96	13577										
PCDHB8	56128	broad.mit.edu	37	chr5	140559901	140559901	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctggcaggaggctcagggacGaatgagttccagttcctgaa	14	9	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:140559901G>A	uc011dai.1	+	1	2472	c.2286G>A	c.(2284-2286)ACG>ACA	p.T762T	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	762	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCAGGGACGAATGAGTTCC	0.517													0	0	0	0.008361	0	30	59										A	140559901	G	A	140559901	2	1	47	1	0	0	0	0	0	0	0	1	11548	1045	37	1		1	PCDHB8	5	140559901	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	5276752	140559901	40355359	97	13578										
PDGFRB	5159	broad.mit.edu	37	chr5	149505034	149505034	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	caagctggtcccgcggcagcTcccacgtggagtcatagggc	14	14	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:149505034T>C	uc003lro.2	-	12	2250	c.1781A>G	c.(1780-1782)GAG>GGG	p.E594G	PDGFRB_uc010jhd.2_Missense_Mutation_p.E433G	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	594	Cytoplasmic (Potential).				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCGCGGCAGCTCCCACGTGGA	0.403			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								0	0	0	0.003163	0	12	11										C	149505034	T	C	149505034	3	2	47	1	0	0	0	0	1	0	0	0	11662	1551	54	5	1587	5	PDGFRB	5	149505034	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	8945133	149505034	31410226	98	13579										
UBLCP1	134510	broad.mit.edu	37	chr5	158702181	158702183	+	In_Frame_Del	DEL	ATT	ATT	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gggagtgagcacaaatgcaaAttataagattactttcatgt							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:158702181_158702183delATT	uc003lxq.2	+	8	937_939	c.611_613delATT	c.(610-615)AATTAT>AAT	p.Y205del		NM_145049	NP_659486	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase	205	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACAAATGCAAATTATAAGATTAC	0.325																		24	61	---	---								-	158702183	ATT	-	158702181	7	5	47	1	0	1	0	1	0	0	0	0	16888	101	4	0	637	0	UBLCP1	5	158702181	In_Frame_Del	DEL	ATT	TCGA-DK-A1AD-01A-11D-A13W-08	9197147	158702181	22213079	99	13580										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171766782	171766782	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagccggagctgggtcacctCgtggggcaggggagccagaa	18	11	1	1	rs138949033		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:171766782C>T	uc003mbr.2	-	13	1498	c.1327G>A	c.(1327-1329)GAG>AAG	p.E443K		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	443					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGTCACCTCGTGGGGCAGG	0.647													0	0	0	0.00499	0	16	18										T	171766782	C	T	171766782	3	4	47	1	0	0	0	0	1	0	0	0	14257	893	31	1	1412	1	SH3PXD2B	5	171766782	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	13064601	171766782	9148478	100	13581										
STC2	8614	broad.mit.edu	37	chr5	172750298	172750298	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgggcagccgcgcacaggtCgtgcttgaggtagcattccc	14	13	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr5:172750298C>T	uc003mco.1	-	3	1740	c.430G>A	c.(430-432)GAC>AAC	p.D144N	STC2_uc003mcn.1_Missense_Mutation_p.D59N	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	144					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCGCACAGGTCGTGCTTGAGG	0.622													0	0	0	0.006122	0	17	24										T	172750298	C	T	172750298	3	4	47	1	0	0	0	0	1	0	0	0	15275	884	31	1	486	1	STC2	5	172750298	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	983516	172750298	8164962	101	13582										
CDYL	9425	broad.mit.edu	37	chr6	4937844	4937844	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgagcacggccgctgccgatGacagcaagctggtactgctc	13	13	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:4937844G>A	uc003mwi.2	+	6	1287	c.1156G>A	c.(1156-1158)GAC>AAC	p.D386N	CDYL_uc003mwj.2_Missense_Mutation_p.D332N|CDYL_uc003mwk.2_Missense_Mutation_p.D97N|CDYL_uc011dhx.1_Missense_Mutation_p.D200N|CDYL_uc011dhy.1_Missense_Mutation_p.D200N	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	386					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CGCTGCCGATGACAGCAAGCT	0.448													0	0	0	0.010729	0	10	26										A	4937844	G	A	4937844	3	1	47	1	0	0	0	0	1	0	0	0	3185	1290	45	1	1008	1	CDYL	6	4937844	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		4937844	166177223	102	13583										
KDM1B	221656	broad.mit.edu	37	chr6	18212790	18212790	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aatccaccgttgtcagagaaGaagatgaaggctatcaacag	10	8	2	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:18212790G>A	uc003nco.1	+	11	1404	c.1329G>A	c.(1327-1329)AAG>AAA	p.K443K	KDM1B_uc003ncn.1_Silent_p.K414K|KDM1B_uc003ncp.1_5'UTR|KDM1B_uc003ncq.1_5'UTR	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	646					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						TGTCAGAGAAGAAGATGAAGG	0.398													0	0	0	0.01441	0	113	683										A	18212790	G	A	18212790	2	1	47	1	0	0	0	0	0	0	0	1	8123	933	33	1		1	KDM1B	6	18212790	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	13274946	18212790	152902277	103	13584										
HIST1H1B	3009	broad.mit.edu	37	chr6	27834978	27834978	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccggaggccgccttcttgttGagtttaaaggagccagaagc	13	10	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:27834978G>C	uc003njx.2	-	1	382	c.330C>G	c.(328-330)CTC>CTG	p.L110L		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	110	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CCTTCTTGTTGAGTTTAAAGG	0.587													0	0	0	0.01441	0	49	187										C	27834978	G	C	27834978	2	2	47	1	0	0	0	0	0	0	0	1	7123	1277	45	1		1	HIST1H1B	6	27834978	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	9622188	27834978	143280089	104	13585										
TRIM27	5987	broad.mit.edu	37	chr6	28889686	28889686	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taccaagagttcagctcgtgCctgttccccctgggcccgac	10	16	1	1	rs112674133		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:28889686C>T	uc003nlr.2	-	2	858	c.499G>A	c.(499-501)GCA>ACA	p.A167T	TRIM27_uc003nls.2_Missense_Mutation_p.A167T|TRIM27_uc003nlt.1_Missense_Mutation_p.A167T	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	167	Potential.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TCAGCTCGTGCCTGTTCCCCC	0.468			T	RET	papillary thyroid								0	0	0	0.005524	0	35	166										T	28889686	C	T	28889686	3	4	47	1	0	0	0	0	1	0	0	0	16498	739	26	2	1070	2	TRIM27	6	28889686	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1054708	28889686	142225381	105	13586										
MDC1	9656	broad.mit.edu	37	chr6	30672275	30672275	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	caggggtcttgacagaggacCtatttgtcctgcccctagtg	12	11	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:30672275C>T	uc003nrg.3	-	10	5125	c.4685G>A	c.(4684-4686)AGG>AAG	p.R1562K	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.R1169K	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1562	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GACAGAGGACCTATTTGTCCT	0.592								Other_conserved_DNA_damage_response_genes					0	0	0	0.01441	0	138	102										T	30672275	C	T	30672275	3	4	47	1	0	0	0	0	1	0	0	0	9403	681	24	2	1608	2	MDC1	6	30672275	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1782589	30672275	140442792	106	13587										
FOXP4	116113	broad.mit.edu	37	chr6	41533702	41533702	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgcacttccagcagcaacaGgtaggaactggtgcgccttg	12	12	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:41533702G>C	uc003oql.2	+	2	662	c.204G>C	c.(202-204)CAG>CAC	p.Q68H	FOXP4_uc003oqm.2_Missense_Mutation_p.Q68H|FOXP4_uc003oqn.2_Missense_Mutation_p.Q68H	NM_001012426	NP_001012426	Q8IVH2	FOXP4_HUMAN	forkhead box P4 isoform 1	68	Gln-rich.				embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					AGCAGCAACAGGTAGGAACTG	0.617													0	0	0	0.013537	0	10	31										C	41533702	G	C	41533702	3	2	47	1	0	0	0	0	1	0	0	0	6029	1014	35	4	206	4	FOXP4	6	41533702	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	10861427	41533702	129581365	107	13588										
LGSN	51557	broad.mit.edu	37	chr6	63990752	63990752	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctgcatgaagggctgatcaTggttatttaaaaatgttaaa	9	5	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:63990752T>C	uc003peh.2	-	4	738	c.704A>G	c.(703-705)CAT>CGT	p.H235R	LGSN_uc003pei.2_Intron	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	235					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	GGGCTGATCATGGTTATTTAA	0.388													0	0	0	0.01441	0	62	62										C	63990752	T	C	63990752	3	2	47	1	0	0	0	0	1	0	0	0	8759	1464	51	5	829	5	LGSN	6	63990752	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	22457050	63990752	107124315	108	13589										
COL19A1	1310	broad.mit.edu	37	chr6	70778319	70778319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctctttttcctcatagggttCcctggggatacaaggccccc	9	14	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:70778319C>T	uc003pfc.1	+	15	1292	c.1175C>T	c.(1174-1176)TCC>TTC	p.S392F	COL19A1_uc010kam.1_Missense_Mutation_p.S288F	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	392	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TCATAGGGTTCCCTGGGGATA	0.408													0	0	0	0.014323	0	20	143										T	70778319	C	T	70778319	3	4	47	1	0	0	0	0	1	0	0	0	3676	855	30	1	1229	1	COL19A1	6	70778319	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	6787567	70778319	100336748	109	13590										
CASP8AP2	9994	broad.mit.edu	37	chr6	90572752	90572752	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttctctttcaaacagtagaActcacaaaaacattgactct	3	11	4	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:90572752A>G	uc003pnr.2	+	7	1520	c.1324A>G	c.(1324-1326)ACT>GCT	p.T442A	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.T442A|CASP8AP2_uc011dzz.1_Missense_Mutation_p.T442A	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	442					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AAACAGTAGAACTCACAAAAA	0.368													0	0	0	0.01441	0	95	77										G	90572752	A	G	90572752	3	3	47	1	0	0	0	0	1	0	0	0	2678	43	2	5	1346	5	CASP8AP2	6	90572752	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	19794433	90572752	80542315	110	13591										
CASP8AP2	9994	broad.mit.edu	37	chr6	90581033	90581033	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atgaccgggaaattttattgGagtgtcagaaaagagggcca	13	5	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:90581033G>C	uc003pnr.2	+	9	6014	c.5818G>C	c.(5818-5820)GAG>CAG	p.E1940Q	CASP8AP2_uc003pns.2_Missense_Mutation_p.E148Q|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1940Q|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1940Q	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1940	NCOA2-binding.				cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		AATTTTATTGGAGTGTCAGAA	0.338													0	0	0	0.010771	0	38	39										C	90581033	G	C	90581033	3	2	47	1	0	0	0	0	1	0	0	0	2678	1175	41	1	5848	1	CASP8AP2	6	90581033	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	8281	90581033	80534034	111	13592										
STX11	8676	broad.mit.edu	37	chr6	144508325	144508325	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcgagcagggtaagtgggaCgtgttttccgagaacttgct	14	7	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:144508325C>T	uc003qks.3	+	2	753	c.561C>T	c.(559-561)GAC>GAT	p.D187D		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	187					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GTAAGTGGGACGTGTTTTCCG	0.637									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.004007	0	16	49										T	144508325	C	T	144508325	2	4	47	1	0	0	0	0	0	0	0	1	15336	535	19	2		2	STX11	6	144508325	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	53927292	144508325	26606742	112	13593										
UTRN	7402	broad.mit.edu	37	chr6	144820449	144820449	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagttggcccggaaaatgaaGaaagaggctgcttctctctc	11	10	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr6:144820449G>A	uc003qkt.2	+	33	4742	c.4650G>A	c.(4648-4650)AAG>AAA	p.K1550K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1550	Interaction with SYNM.|Spectrin 11.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGAAAATGAAGAAAGAGGCTG	0.478													0	0	0	0.020292	0	14	60										A	144820449	G	A	144820449	2	1	47	1	0	0	0	0	0	0	0	1	17100	933	33	1		1	UTRN	6	144820449	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	312124	144820449	26294618	113	13594										
ACTB	60	broad.mit.edu	37	chr7	5567464	5567464	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tctgctggaaggtggacagcGaggccaggatggagccgccg	18	10	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:5567464G>A	uc003sos.3	-	5	1079	c.1043C>T	c.(1042-1044)TCG>TTG	p.S348L	ACTB_uc003sor.3_Missense_Mutation_p.S226L|ACTB_uc003sot.3_Missense_Mutation_p.S348L|ACTB_uc003soq.3_Missense_Mutation_p.S226L|ACTB_uc010ksy.2_Missense_Mutation_p.S226L	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	348					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GGTGGACAGCGAGGCCAGGAT	0.587													0	0	0	0.008871	0	17	104										A	5567464	G	A	5567464	3	1	47	1	0	0	0	0	1	0	0	0	193	1059	37	1	88	1	ACTB	7	5567464	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		5567464	153571199	114	13595										
ZNF716	441234	broad.mit.edu	37	chr7	57528875	57528875	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agacataaaagaattcatacTggagagaaaccctacagatg	8	7	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:57528875T>C	uc011kdi.1	+	4	820	c.708T>C	c.(706-708)ACT>ACC	p.T236T		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						GAATTCATACTGGAGAGAAAC	0.378													0	0	0	0.014758	0	5	28										C	57528875	T	C	57528875	2	2	47	1	0	0	0	0	0	0	0	1	18116	1567	55	5		5	ZNF716	7	57528875	Silent	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	51961411	57528875	101609788	115	13596										
POM121	9883	broad.mit.edu	37	chr7	72410394	72410395	+	Frame_Shift_Del	DEL	AC	AC	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttctttctttagctgcagatAcaaccccaaggaagaaacaa							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:72410394_72410395delAC	uc003twk.2	+	8	1450_1451	c.1450_1451delAC	c.(1450-1452)ACAfs	p.T484fs	POM121_uc003twj.2_Frame_Shift_Del_p.T219fs|POM121_uc010lam.1_Frame_Shift_Del_p.T219fs	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	484	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AGCTGCAGATACAACCCCAAGG	0.48																		115	181	---	---								-	72410395	AC	-	72410394	7	5	47	1	0	1	0	1	0	0	0	0	12239	391	14	0	681	0	POM121	7	72410394	Frame_Shift_Del	DEL	AC	TCGA-DK-A1AD-01A-11D-A13W-08	14881519	72410394	86728269	116	13597										
SEMA3D	223117	broad.mit.edu	37	chr7	84671572	84671572	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agaaaagtcgtccacttgttTatcaggctgcgttgtcctcc	9	11	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:84671572T>C	uc003uic.2	-	8	931	c.891A>G	c.(889-891)ATA>ATG	p.I297M	SEMA3D_uc010led.2_Missense_Mutation_p.I297M|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	297	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TCCACTTGTTTATCAGGCTGC	0.378													0	0	0	0.01441	0	193	306										C	84671572	T	C	84671572	3	2	47	1	0	0	0	0	1	0	0	0	14027	1744	61	5	1482	5	SEMA3D	7	84671572	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	12261178	84671572	74467091	117	13598										
C7orf43	55262	broad.mit.edu	37	chr7	99753312	99753312	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acctcgaagagccccgtcctCagagcctggaaggccacact	10	16	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:99753312C>G	uc003utr.2	-	9	1557	c.1377G>C	c.(1375-1377)CTG>CTC	p.L459L	C7orf43_uc010lgo.2_Silent_p.L85L|C7orf43_uc010lgp.2_Silent_p.L81L|C7orf43_uc011kjj.1_Silent_p.L227L|C7orf43_uc003uts.2_Silent_p.L190L	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	459											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCCCGTCCTCAGAGCCTGGA	0.637													0	0	0	0.01441	0	77	116										G	99753312	C	G	99753312	2	3	47	1	0	0	0	0	0	0	0	1	2393	813	29	1		1	C7orf43	7	99753312	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	15081740	99753312	59385351	118	13599										
C7orf51	222950	broad.mit.edu	37	chr7	100087130	100087130	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agctgcaggagcaagggaccGatgggggtgcttttgccagc	17	9	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:100087130G>T	uc003uvd.1	+	4	1945	c.1786G>T	c.(1786-1788)GAT>TAT	p.D596Y	C7orf51_uc003uve.1_Missense_Mutation_p.D378Y	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	596										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAAGGGACCGATGGGGGTGC	0.637													1	0	9.8876e-21	0.021022	1.07805e-20	34	71										T	100087130	G	T	100087130	3	4	47	1	0	0	0	0	1	0	0	0	2400	1058	37	3	1796	3	C7orf51	7	100087130	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	333818	100087130	59051533	119	13600										
C7orf58	79974	broad.mit.edu	37	chr7	120770316	120770316	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttgaacaatttcagttcatGaataaaaagacacagccaca	5	8	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:120770316G>A	uc003vjq.3	+	12	1992	c.1545G>A	c.(1543-1545)ATG>ATA	p.M515I	C7orf58_uc003vjr.1_Missense_Mutation_p.M515I|C7orf58_uc003vjs.3_Missense_Mutation_p.M515I|C7orf58_uc003vjt.3_Missense_Mutation_p.M295I|C7orf58_uc010lkk.1_Missense_Mutation_p.M295I	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	515						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTCAGTTCATGAATAAAAAGA	0.358													0	0	0	0.01441	0	48	74										A	120770316	G	A	120770316	3	1	47	1	0	0	0	0	1	0	0	0	2405	1290	45	1	1587	1	C7orf58	7	120770316	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	20683186	120770316	38368347	120	13601										
LRRC4	64101	broad.mit.edu	37	chr7	127670603	127670603	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agcagcgatggctgcacacaGaatccacacttgcgccgtga	11	13	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:127670603G>A	uc003vmk.2	-	2	228	c.91C>T	c.(91-93)CTG>TTG	p.L31L	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	31						cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GCTGCACACAGAATCCACACT	0.622													0	0	0	0.01441	0	59	79										A	127670603	G	A	127670603	2	1	47	1	0	0	0	0	0	0	0	1	8997	933	33	1		1	LRRC4	7	127670603	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	6900287	127670603	31468060	121	13602										
FAM71F1	84691	broad.mit.edu	37	chr7	128355645	128355645	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggagagccgaaccctggagcGggcctaggtgtggaggaggg	21	8	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:128355645G>T	uc003vno.1	+	1	203	c.150G>T	c.(148-150)GCG>GCT	p.A50A	FAM71F1_uc010llo.1_Intron|FAM71F1_uc011koq.1_Intron|FAM71F1_uc003vnm.1_Intron|FAM71F1_uc003vnn.1_Intron|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Silent_p.A50A	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	50										skin(1)	1						ACCCTGGAGCGGGCCTAGGTG	0.537													1	0	2.44813e-32	0.01441	2.75204e-32	59	85										T	128355645	G	T	128355645	2	4	47	1	0	0	0	0	0	0	0	1	5612	1103	39	4		4	FAM71F1	7	128355645	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	685042	128355645	30783018	122	13603										
INSIG1	3638	broad.mit.edu	37	chr7	155093959	155093959	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tccttaacttttatatcaccAgaaattggattttgccaata	4	8	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr7:155093959A>C	uc003wly.2	+	4	749	c.538_splice	c.e4-2	p.K180_splice	INSIG1_uc011kvu.1_Splice_Site_p.K28_splice|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1						cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTATATCACCAGAAATTGGAT	0.378													0	0	0	0.01441	0	58	87										C	155093959	A	C	155093959	5	2	47	1	0	0	0	0	0	0	1	0	7765	202	7	5	546	5	INSIG1	7	155093959	Splice_Site	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	26738314	155093959	4044704	123	13604										
PNOC	5368	broad.mit.edu	37	chr8	28196662	28196662	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agctcagccctgccgccccaGagcatgtggcggctgctctc	12	17	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:28196662G>C	uc010lva.2	+	3	440	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	PNOC_uc003xgp.2_Missense_Mutation_p.E78Q|PNOC_uc011lau.1_Missense_Mutation_p.E14Q	NM_006228	NP_006219	Q13519	PNOC_HUMAN	prepronociceptin precursor	78					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)	1		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		TGCCGCCCCAGAGCATGTGGC	0.632													0	0	0	0.016723	0	11	5										C	28196662	G	C	28196662	3	2	47	1	0	0	0	0	1	0	0	0	12162	943	33	1	238	1	PNOC	8	28196662	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		28196662	118167360	124	13605										
TEX15	56154	broad.mit.edu	37	chr8	30702296	30702296	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tatcttcttcagttcctgatGctacatccaactcataattc	3	12	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:30702296G>T	uc003xil.2	-	1	4238	c.4238C>A	c.(4237-4239)GCA>GAA	p.A1413E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1413										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGTTCCTGATGCTACATCCAA	0.363													1	0	1.06522e-23	0.013114	1.17716e-23	42	43										T	30702296	G	T	30702296	3	4	47	1	0	0	0	0	1	0	0	0	15776	1319	46	4	4147	4	TEX15	8	30702296	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	2505634	30702296	115661726	125	13606										
UNC5D	137970	broad.mit.edu	37	chr8	35584024	35584024	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgtctttggccatttaggggGgcgcttagtaatgccaaata	12	7	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:35584024G>T	uc003xjr.1	+	10	1986	c.1658G>T	c.(1657-1659)GGG>GTG	p.G553V	UNC5D_uc003xjs.1_Missense_Mutation_p.G548V|UNC5D_uc003xju.1_Missense_Mutation_p.G129V|UNC5D_uc003xjt.1_Missense_Mutation_p.G311V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	553	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CATTTAGGGGGGCGCTTAGTA	0.413													1	0	6.4771e-29	0.010771	7.23128e-29	41	42										T	35584024	G	T	35584024	3	4	47	1	0	0	0	0	1	0	0	0	16992	1232	43	4	1696	4	UNC5D	8	35584024	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	4881728	35584024	110779998	126	13607										
KCNU1	157855	broad.mit.edu	37	chr8	36662755	36662755	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tatgaagacaaaaccattccTattgatttggttttcaatgc	6	7	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:36662755T>C	uc010lvw.2	+	4	507	c.420T>C	c.(418-420)CCT>CCC	p.P140P	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	140	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AAACCATTCCTATTGATTTGG	0.363													0	0	0	0.00308	0	7	5										C	36662755	T	C	36662755	2	2	47	1	0	0	0	0	0	0	0	1	8093	1509	53	5		5	KCNU1	8	36662755	Silent	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	1078731	36662755	109701267	127	13608										
ADAM2	2515	broad.mit.edu	37	chr8	39607251	39607251	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgaagaactcacacatctttGattcctgcaaacctaaaaag	5	10	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:39607251G>C	uc003xnj.2	-	17	1885	c.1810C>G	c.(1810-1812)CAA>GAA	p.Q604E	ADAM2_uc003xnk.2_Missense_Mutation_p.Q585E|ADAM2_uc011lck.1_Missense_Mutation_p.Q541E|ADAM2_uc003xnl.2_Missense_Mutation_p.Q448E	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	604	Extracellular (Potential).|Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACACATCTTTGATTCCTGCAA	0.343													0	0	0	0.007835	0	38	94										C	39607251	G	C	39607251	3	2	47	1	0	0	0	0	1	0	0	0	241	1299	45	1	413	1	ADAM2	8	39607251	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	2944496	39607251	106756771	128	13609										
CHD7	55636	broad.mit.edu	37	chr8	61653990	61653990	+	Translation_Start_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aggagccgtgtgttggaagaAgatggcagatccaggaatga	16	5	0	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:61653990A>T	uc003xue.2	+	2	476	c.-1A>T	c.(-3-1)GAAGA>GATGA			NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TGTTGGAAGAAGATGGCAGAT	0.478													0	0	0	0.004672	0	3	12										T	61653990	A	T	61653990	1	4	47	1	0	0	0	0	0	0	0	0	3330	87	3	5		5	CHD7	8	61653990	Translation_Start_Site	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	22046739	61653990	84710032	129	13610										
CHD7	55636	broad.mit.edu	37	chr8	61765060	61765060	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tataatctttctaacaggtgGacaagaagagaagaggctga	11	5	2	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:61765060G>C	uc003xue.2	+	30	6375	c.5898G>C	c.(5896-5898)TGG>TGC	p.W1966C		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1966					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTAACAGGTGGACAAGAAGAG	0.383													0	0	0	0.008291	0	11	33										C	61765060	G	C	61765060	3	2	47	1	0	0	0	0	1	0	0	0	3330	1183	41	1	6012	1	CHD7	8	61765060	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	111070	61765060	84598962	130	13611										
TRHR	7201	broad.mit.edu	37	chr8	110100398	110100398	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcatagctagaatccttttCttaaatcccattccttcaga	3	11	3	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:110100398C>T	uc003ymz.3	+	1	673	c.657C>T	c.(655-657)TTC>TTT	p.F219F		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	219	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GAATCCTTTTCTTAAATCCCA	0.358													0	0	0	0.019004	0	34	119										T	110100398	C	T	110100398	2	4	47	1	0	0	0	0	0	0	0	1	16477	912	32	1		1	TRHR	8	110100398	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	48335338	110100398	36263624	131	13612										
RAD21	5885	broad.mit.edu	37	chr8	117859890	117859890	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcgtatttcgacataactcaAgcaaactgatagattcagct	6	9	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:117859890A>G	uc003yod.2	-	14	2033	c.1745T>C	c.(1744-1746)CTT>CCT	p.L582P		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	582					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					ACATAACTCAAGCAAACTGAT	0.378													0	0	0	0.014323	0	23	101										G	117859890	A	G	117859890	3	3	47	1	0	0	0	0	1	0	0	0	12981	72	3	5	154	5	RAD21	8	117859890	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	7759492	117859890	28504132	132	13613										
RAD21	5885	broad.mit.edu	37	chr8	117870623	117870623	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttgtaaaatactgatgttcCcaacttcttctctcatggtt	5	10	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:117870623C>A	uc003yod.2	-	5	737	c.449G>T	c.(448-450)GGG>GTG	p.G150V		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	150					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					ACTGATGTTCCCAACTTCTTC	0.318													1	0	3.01185e-09	0.021523	3.147e-09	24	162										A	117870623	C	A	117870623	3	1	47	1	0	0	0	0	1	0	0	0	12981	623	22	4	1486	4	RAD21	8	117870623	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	10733	117870623	28493399	133	13614										
EXT1	2131	broad.mit.edu	37	chr8	119122781	119122781	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tctcaaattgtgcacatactGaggtgacaactggtctctgt	9	9	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:119122781G>A	uc003yok.1	-	1	1278	c.505C>T	c.(505-507)CAG>TAG	p.Q169*		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	169	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TGCACATACTGAGGTGACAAC	0.483			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				0	0	0	0.01441	0	228	202										A	119122781	G	A	119122781	4	1	47	1	0	0	0	0	0	1	0	0	5323	1299	45	1	1779	1	EXT1	8	119122781	Nonsense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1252158	119122781	27241241	134	13615										
ZHX1	11244	broad.mit.edu	37	chr8	124267128	124267128	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	actgttccattgaattgtttCcttcttgcctcctctacttc	4	13	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:124267128C>T	uc003yqe.2	-	3	1489	c.1059G>A	c.(1057-1059)AGG>AGA	p.R353R	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Silent_p.R353R|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Silent_p.R353R	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	353	Required for dimerization.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGAATTGTTTCCTTCTTGCCT	0.398													0	0	0	0.01441	0	284	240										T	124267128	C	T	124267128	2	4	47	1	0	0	0	0	0	0	0	1	17672	854	30	1		1	ZHX1	8	124267128	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	5144347	124267128	22096894	135	13616										
ATAD2	29028	broad.mit.edu	37	chr8	124371525	124371525	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taatggaaacaccaccatctCttttagagctgctatatgat	6	9	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:124371525C>G	uc003yqh.3	-	11	1426	c.1318G>C	c.(1318-1320)GAG>CAG	p.E440Q	ATAD2_uc011lii.1_Missense_Mutation_p.E231Q|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E440Q	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			ACCACCATCTCTTTTAGAGCT	0.328													0	0	0	0.01441	0	81	333										G	124371525	C	G	124371525	3	3	47	1	0	0	0	0	1	0	0	0	1071	922	32	1	2926	1	ATAD2	8	124371525	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	104397	124371525	21992497	136	13617										
KLHL38	340359	broad.mit.edu	37	chr8	124664012	124664012	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccaatccccccgatggagaaGatgaagttcttatgggcagt	11	10	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:124664012G>C	uc003yqs.1	-	1	1179	c.1155C>G	c.(1153-1155)ATC>ATG	p.I385M		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	385	Kelch 3.										0						CGATGGAGAAGATGAAGTTCT	0.557													0	0	0	0.009535	0	30	130										C	124664012	G	C	124664012	3	2	47	1	0	0	0	0	1	0	0	0	8390	932	33	1	602	1	KLHL38	8	124664012	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	292487	124664012	21700010	137	13618										
KIAA0196	9897	broad.mit.edu	37	chr8	126061284	126061284	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttattacactcttgctccacGttgtaatttatgatacgaga	6	8	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:126061284G>A	uc003yrt.2	-	19	2672	c.2343C>T	c.(2341-2343)AAC>AAT	p.N781N	KIAA0196_uc011lir.1_Silent_p.N633N|KIAA0196_uc003yru.1_Silent_p.N355N	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	781					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTTGCTCCACGTTGTAATTTA	0.323													0	0	0	0.007413	0	19	94										A	126061284	G	A	126061284	2	1	47	1	0	0	0	0	0	0	0	1	8161	1136	40	2		2	KIAA0196	8	126061284	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1397272	126061284	20302738	138	13619										
KHDRBS3	10656	broad.mit.edu	37	chr8	136594189	136594189	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agggacgccaactcccagagGagtcctgtccacccgagggc	13	15	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:136594189G>T	uc003yuv.2	+	6	1074	c.680G>T	c.(679-681)GGA>GTA	p.G227V	KHDRBS3_uc003yuw.2_Missense_Mutation_p.G227V|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	227	Interaction with SIAH1.			Missing: Complete loss of SIAH1-mediated degradation.	regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			ACTCCCAGAGGAGTCCTGTCC	0.592													1	0	4.22769e-11	0.00632	4.47477e-11	29	101										T	136594189	G	T	136594189	3	4	47	1	0	0	0	0	1	0	0	0	8148	1174	41	3	702	3	KHDRBS3	8	136594189	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	10532905	136594189	9769833	139	13620										
KHDRBS3	10656	broad.mit.edu	37	chr8	136594225	136594225	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agggccagtgagtcggggaaGaggacttctcactcccagag	15	10	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:136594225G>T	uc003yuv.2	+	6	1110	c.716G>T	c.(715-717)AGA>ATA	p.R239I	KHDRBS3_uc003yuw.2_Missense_Mutation_p.R239I|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	239	Interaction with SIAH1.			Missing: Complete loss of SIAH1-mediated degradation.	regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			AGTCGGGGAAGAGGACTTCTC	0.587													1	0	4.7796e-09	0.004656	4.97812e-09	27	97										T	136594225	G	T	136594225	3	4	47	1	0	0	0	0	1	0	0	0	8148	942	33	3	738	3	KHDRBS3	8	136594225	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	36	136594225	9769797	140	13621										
EIF2C2	27161	broad.mit.edu	37	chr8	141549532	141549532	+	Frame_Shift_Del	DEL	C	C	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gatacaggcctcacggatggCcagcaactcgtggtggagaa							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:141549532delC	uc003yvn.2	-	16	2096	c.2056delG	c.(2056-2058)GCCfs	p.A686fs	EIF2C2_uc010men.2_Frame_Shift_Del_p.A609fs|EIF2C2_uc010meo.2_Frame_Shift_Del_p.A686fs	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	686	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TCACGGATGGCCAGCAACTCG	0.572																		25	112	---	---								-	141549532	C	-	141549532	7	5	47	1	0	1	0	1	0	0	0	0	5006	739	26	0	539	0	EIF2C2	8	141549532	Frame_Shift_Del	DEL	C	TCGA-DK-A1AD-01A-11D-A13W-08	4955307	141549532	4814490	141	13622										
SCRIB	23513	broad.mit.edu	37	chr8	144895029	144895029	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagcaggttctgggacagcaGcaggtcagtgagcagcacca	14	11	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:144895029G>A	uc003yzp.1	-	8	752	c.745C>T	c.(745-747)CTG>TTG	p.L249L	SCRIB_uc003yzo.1_Silent_p.L249L	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	249	LRR 10.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TGGGACAGCAGCAGGTCAGTG	0.701													0	0	0	0.009096	0	3	18										A	144895029	G	A	144895029	2	1	47	1	0	0	0	0	0	0	0	1	13937	962	34	2		2	SCRIB	8	144895029	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	3345497	144895029	1468993	142	13623										
ADCK5	203054	broad.mit.edu	37	chr8	145608287	145608287	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	attgtctctcctcaggttctCcagccccacacccctgtgga	7	17	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr8:145608287C>G	uc003zch.2	+	3	176	c.122C>G	c.(121-123)TCC>TGC	p.S41C	ADCK5_uc003zcg.2_RNA	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	41						integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTCAGGTTCTCCAGCCCCACA	0.672													0	0	0	0.009096	0	2	2										G	145608287	C	G	145608287	3	3	47	1	0	0	0	0	1	0	0	0	291	855	30	1	132	1	ADCK5	8	145608287	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	713258	145608287	755735	143	13624										
GLDC	2731	broad.mit.edu	37	chr9	6589258	6589258	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acacagaccctggaatacctCtgcactcctctcccatgctt	5	17	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:6589258C>G	uc003zkc.2	-	12	1710	c.1517G>C	c.(1516-1518)AGA>ACA	p.R506T		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	506					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGGAATACCTCTGCACTCCTC	0.517													0	0	0	0.007835	0	40	40										G	6589258	C	G	6589258	3	3	47	1	0	0	0	0	1	0	0	0	6433	913	32	1	1601	1	GLDC	9	6589258	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		6589258	134624173	144	13625										
PTPRD	5789	broad.mit.edu	37	chr9	8518200	8518200	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggaggcccccgcccaatgttAttgacagcaacaaccctgaa	9	14	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:8518200A>T	uc003zkk.2	-	20	1902	c.1191T>A	c.(1189-1191)AAT>AAA	p.N397K	PTPRD_uc003zkp.2_Missense_Mutation_p.N397K|PTPRD_uc003zkq.2_Missense_Mutation_p.N397K|PTPRD_uc003zkr.2_Missense_Mutation_p.N391K|PTPRD_uc003zks.2_Missense_Mutation_p.N387K|PTPRD_uc003zkl.2_Missense_Mutation_p.N397K|PTPRD_uc003zkm.2_Missense_Mutation_p.N384K|PTPRD_uc003zkn.2_Missense_Mutation_p.N397K|PTPRD_uc003zko.2_Missense_Mutation_p.N394K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	397	Fibronectin type-III 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCCCAATGTTATTGACAGCAA	0.522										TSP Lung(15;0.13)			0	0	0	0.01441	0	57	186										T	8518200	A	T	8518200	3	4	47	1	0	0	0	0	1	0	0	0	12799	446	16	5	4719	5	PTPRD	9	8518200	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	1928942	8518200	132695231	145	13626										
KLHL9	55958	broad.mit.edu	37	chr9	21334596	21334596	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcttaatgcacatcaaatctTgttctttcattccacctgtg	5	11	4	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:21334596T>C	uc003zoy.2	-	1	834	c.263A>G	c.(262-264)CAA>CGA	p.Q88R	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	88	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		CATCAAATCTTGTTCTTTCAT	0.378													0	0	0	0.01441	0	72	266										C	21334596	T	C	21334596	3	2	47	1	0	0	0	0	1	0	0	0	8396	1812	63	5	1594	5	KLHL9	9	21334596	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	12816396	21334596	119878835	146	13627										
IFT74	80173	broad.mit.edu	37	chr9	26984496	26984496	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtatttattttatgctttcaGggctgagactttagctgttg	10	5	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:26984496G>A	uc010mja.2	+	6	532	c.405_splice	c.e6-1	p.R135_splice	IFT74_uc010mjb.2_Splice_Site_p.R135_splice|IFT74_uc003zqf.3_Splice_Site_p.R135_splice|IFT74_uc003zqg.3_Splice_Site_p.R135_splice	NM_001099223	NP_001092693	Q96LB3	IFT74_HUMAN	coiled-coil domain containing 2 isoform a							cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TATGCTTTCAGGGCTGAGACT	0.269													0	0	0	0.01441	0	70	143										A	26984496	G	A	26984496	5	1	47	1	0	0	0	0	0	0	1	0	7563	1014	35	2	422	2	IFT74	9	26984496	Splice_Site	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	5649900	26984496	114228935	147	13628										
KIAA1161	57462	broad.mit.edu	37	chr9	34372097	34372097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgtctgagcccacgcacactCggtagctcagctctggcgct	11	16	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:34372097C>T	uc003zue.3	-	3	1012	c.845G>A	c.(844-846)CGA>CAA	p.R282Q		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	282	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CACGCACACTCGGTAGCTCAG	0.662													0	0	0	0.00308	0	7	35										T	34372097	C	T	34372097	3	4	47	1	0	0	0	0	1	0	0	0	8211	884	31	1	1303	1	KIAA1161	9	34372097	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7387601	34372097	106841334	148	13629										
C9orf131	138724	broad.mit.edu	37	chr9	35044993	35044993	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tggagtagagagctgaaactCaggctgaagaaactgcggca	14	7	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:35044993C>G	uc003zvw.2	+	2	2396	c.2367C>G	c.(2365-2367)CTC>CTG	p.L789L	C9orf131_uc003zvu.2_Silent_p.L741L|C9orf131_uc003zvv.2_Silent_p.L716L|C9orf131_uc003zvx.2_Silent_p.L754L	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	789											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			AGCTGAAACTCAGGCTGAAGA	0.567													0	0	0	0.01441	0	103	173										G	35044993	C	G	35044993	2	3	47	1	0	0	0	0	0	0	0	1	2457	813	29	1		1	C9orf131	9	35044993	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	672896	35044993	106168438	149	13630										
TLN1	7094	broad.mit.edu	37	chr9	35697854	35697854	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgccggatctgggccagtttCttccgcgcctcttccagctc	10	16	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:35697854C>T	uc003zxt.2	-	57	7914	c.7560G>A	c.(7558-7560)AAG>AAA	p.K2520K		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2520	I/LWEQ.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGGCCAGTTTCTTCCGCGCCT	0.532											OREG0019174	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016723	0	14	64										T	35697854	C	T	35697854	2	4	47	1	0	0	0	0	0	0	0	1	15944	912	32	1		1	TLN1	9	35697854	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	652861	35697854	105515577	150	13631										
TJP2	9414	broad.mit.edu	37	chr9	71844146	71844146	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acttttcttcgtcctagtccTgaagatgaagcaatatatgg	8	8	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:71844146T>G	uc004ahe.2	+	10	1700	c.1500T>G	c.(1498-1500)CCT>CCG	p.P500P	TJP2_uc011lrs.1_Silent_p.P477P|TJP2_uc011lrt.1_Silent_p.P477P|TJP2_uc004ahd.2_Silent_p.P500P|TJP2_uc004ahf.2_Silent_p.P500P|TJP2_uc011lru.1_Silent_p.P504P|TJP2_uc011lrv.1_Silent_p.P522P	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	500					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GTCCTAGTCCTGAAGATGAAG	0.423													0	0	0	0.01441	0	66	55										G	71844146	T	G	71844146	2	3	47	1	0	0	0	0	0	0	0	1	15927	1567	55	5		5	TJP2	9	71844146	Silent	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	36146292	71844146	69369285	151	13632										
TRPM6	140803	broad.mit.edu	37	chr9	77377272	77377272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gatcttggcttgggaaagagGggagctcattgtcatgggtt	16	5	3	1	rs144291419		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:77377272G>A	uc004ajl.1	-	26	4553	c.4315C>T	c.(4315-4317)CCT>TCT	p.P1439S	TRPM6_uc004ajk.1_Missense_Mutation_p.P1434S|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.P395S	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1439	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGGGAAAGAGGGGAGCTCATT	0.463													0	0	0	0.004656	0	25	69										A	77377272	G	A	77377272	3	1	47	1	0	0	0	0	1	0	0	0	16587	1232	43	2	1809	2	TRPM6	9	77377272	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	5533126	77377272	63836159	152	13633										
PCSK5	5125	broad.mit.edu	37	chr9	78784732	78784732	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagtttatgatactccctctCagctaaggaactttaagact	6	9	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:78784732C>T	uc004ajz.2	+	13	2270	c.1732C>T	c.(1732-1734)CAG>TAG	p.Q578*	PCSK5_uc004ajy.2_Nonsense_Mutation_p.Q578*|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	578	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						TACTCCCTCTCAGCTAAGGAA	0.428													0	0	0	0.01441	0	51	89										T	78784732	C	T	78784732	4	4	47	1	0	0	0	0	0	1	0	0	11603	827	29	1	1782	1	PCSK5	9	78784732	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1407460	78784732	62428699	153	13634										
BICD2	23299	broad.mit.edu	37	chr9	95477535	95477535	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	caggcacaggtgtgacttacGctcggtgtggctggcttggt	16	9	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:95477535G>A	uc004aso.1	-	7	2526	c.2469C>T	c.(2467-2469)AGC>AGT	p.S823S	BICD2_uc004asp.1_Silent_p.S823S	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	823					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						TGTGACTTACGCTCGGTGTGG	0.652													0	0	0	0.00308	0	5	4										A	95477535	G	A	95477535	2	1	47	1	0	0	0	0	0	0	0	1	1429	1101	38	2		2	BICD2	9	95477535	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	16692803	95477535	45735896	154	13635										
PTCH1	5727	broad.mit.edu	37	chr9	98221997	98221997	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gggtcgttgctgacccaagcCgtcaggtagatgtagaaagc	14	9	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:98221997C>A	uc004avk.3	-	17	2960	c.2772G>T	c.(2770-2772)ACG>ACT	p.T924T	PTCH1_uc010mro.2_Silent_p.T773T|PTCH1_uc010mrp.2_Silent_p.T773T|PTCH1_uc010mrq.2_Silent_p.T773T|PTCH1_uc004avl.3_Silent_p.T773T|PTCH1_uc010mrr.2_Silent_p.T858T|PTCH1_uc004avm.3_Silent_p.T923T	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	924	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TGACCCAAGCCGTCAGGTAGA	0.552									Basal_Cell_Nevus_syndrome				1	0	3.5997e-14	0.014323	3.83497e-14	24	29										A	98221997	C	A	98221997	2	1	47	1	0	0	0	0	0	0	0	1	12730	639	23	4		4	PTCH1	9	98221997	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2744462	98221997	42991434	155	13636										
ZNF322B	387328	broad.mit.edu	37	chr9	99960733	99960733	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggaagcttttatcacatacaGtgtatttatagtgtagctcc	8	7	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:99960733G>A	uc004axd.1	-	1	1178	c.1061C>T	c.(1060-1062)ACT>ATT	p.T354I	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				ATCACATACAGTGTATTTATA	0.433													0	0	0	0.01441	0	61	128										A	99960733	G	A	99960733	3	1	47	1	0	0	0	0	1	0	0	0	17839	1029	36	2	151	2	ZNF322B	9	99960733	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1738736	99960733	41252698	156	13637										
SMC2	10592	broad.mit.edu	37	chr9	106894304	106894304	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcatagtacaatgacttgatGaagaagaagagaattgtaga	10	3	1	7			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:106894304G>C	uc004bbv.2	+	22	3294	c.3006G>C	c.(3004-3006)ATG>ATC	p.M1002I	SMC2_uc004bbw.2_Missense_Mutation_p.M1002I|SMC2_uc011lvl.1_Missense_Mutation_p.M1002I|SMC2_uc004bbx.2_Missense_Mutation_p.M1002I|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1002	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						ATGACTTGATGAAGAAGAAGA	0.303													0	0	0	0.021523	0	26	24										C	106894304	G	C	106894304	3	2	47	1	0	0	0	0	1	0	0	0	14783	1290	45	1	3088	1	SMC2	9	106894304	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	6933571	106894304	34319127	157	13638										
CRAT	1384	broad.mit.edu	37	chr9	131864786	131864786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcggcaggaggacaagatctGatagtactggttcatgcaca	12	8	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr9:131864786G>C	uc004bxh.2	-	5	805	c.523C>G	c.(523-525)CAG>GAG	p.Q175E	CRAT_uc004bxg.2_Missense_Mutation_p.Q154E|CRAT_uc004bxk.3_Missense_Mutation_p.Q154E	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	175					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	GACAAGATCTGATAGTACTGG	0.597													0	0	0	0.01441	0	89	170										C	131864786	G	C	131864786	3	2	47	1	0	0	0	0	1	0	0	0	3847	1299	45	1	1397	1	CRAT	9	131864786	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	24970482	131864786	9348645	158	13639										
MYO3A	53904	broad.mit.edu	37	chr10	26377316	26377316	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atatctcctggaaaaatcccGagttatccaccaagctatgt	6	11	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:26377316G>T	uc001isn.2	+	15	1904	c.1544G>T	c.(1543-1545)CGA>CTA	p.R515L	MYO3A_uc009xko.1_Missense_Mutation_p.R515L|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.R515L	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	515	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAAAAATCCCGAGTTATCCAC	0.348													1	0	8.83742e-36	0.01441	9.96885e-36	73	47										T	26377316	G	T	26377316	3	4	47	1	0	0	0	0	1	0	0	0	10076	1058	37	3	1594	3	MYO3A	10	26377316	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		26377316	109157431	159	13640										
BMS1	9790	broad.mit.edu	37	chr10	43292463	43292463	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgaagaggtgtttgcatctGaagatgaatctgaagaaagc	12	5	2	7	rs145513181		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:43292463G>A	uc001jaj.2	+	10	2129	c.1771G>A	c.(1771-1773)GAA>AAA	p.E591K		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	591					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GTTTGCATCTGAAGATGAATC	0.448													0	0	0	0.021523	0	23	82										A	43292463	G	A	43292463	3	1	47	1	0	0	0	0	1	0	0	0	1472	1291	45	1	1805	1	BMS1	10	43292463	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	16915147	43292463	92242284	160	13641										
SLC18A3	6572	broad.mit.edu	37	chr10	50819136	50819136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccttcggccccgctaccctaCggagagcgaagacgtgaaga	12	14	0	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:50819136C>T	uc001jhw.2	+	1	790	c.350C>T	c.(349-351)ACG>ATG	p.T117M	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	117	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						CGCTACCCTACGGAGAGCGAA	0.657													0	0	0	0.00632	0	25	47										T	50819136	C	T	50819136	3	4	47	1	0	0	0	0	1	0	0	0	14427	536	19	2	352	2	SLC18A3	10	50819136	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7526673	50819136	84715611	161	13642										
ADAMTS14	140766	broad.mit.edu	37	chr10	72511899	72511899	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcgcagacgagaccaccacaTggtgcagcgacacctgtgtg	13	13	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:72511899T>G	uc001jrh.2	+	18	2645	c.2645T>G	c.(2644-2646)ATG>AGG	p.M882R	ADAMTS14_uc001jrg.2_Missense_Mutation_p.M885R	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	882	TSP type-1 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GACCACCACATGGTGCAGCGA	0.657													0	0	0	0.001984	0	6	15										G	72511899	T	G	72511899	3	3	47	1	0	0	0	0	1	0	0	0	259	1464	51	5	2724	5	ADAMTS14	10	72511899	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	21692763	72511899	63022848	162	13643										
CDH23	64072	broad.mit.edu	37	chr10	73494069	73494069	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccttgacagtggtggcagatGacggcggccccaaggtggac	16	11	0	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:73494069G>A	uc001jrx.3	+	32	4554	c.4177G>A	c.(4177-4179)GAC>AAC	p.D1393N	C10orf105_uc001jsb.1_Intron|CDH23_uc001jsc.1_Missense_Mutation_p.D201N	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1393	Cadherin 13.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGTGGCAGATGACGGCGGCCC	0.622													0	0	0	0.004672	0	3	8										A	73494069	G	A	73494069	3	1	47	1	0	0	0	0	1	0	0	0	3108	1290	45	1	4652	1	CDH23	10	73494069	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	982170	73494069	62040678	163	13644										
TTC18	118491	broad.mit.edu	37	chr10	75051461	75051461	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agcatcctcaaagaaaatttCtgcttgctcatagttctcca	5	11	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:75051461C>G	uc009xrc.2	-	19	2288	c.2167G>C	c.(2167-2169)GAA>CAA	p.E723Q	TTC18_uc001jty.2_Missense_Mutation_p.E723Q|TTC18_uc001jtv.3_5'Flank|TTC18_uc001jtw.3_5'Flank|TTC18_uc001jtx.2_Missense_Mutation_p.E104Q	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	723	TPR 3.						binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					AAGAAAATTTCTGCTTGCTCA	0.418													0	0	0	0.020292	0	15	25										G	75051461	C	G	75051461	3	3	47	1	0	0	0	0	1	0	0	0	16682	922	32	1	1238	1	TTC18	10	75051461	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1557392	75051461	60483286	164	13645										
ZMYND17	118490	broad.mit.edu	37	chr10	75184443	75184443	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gaatagacctgttcaggtttGagggacatgaaaggattaga	13	4	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:75184443G>C	uc001jud.2	-	7	1317	c.1251C>G	c.(1249-1251)CTC>CTG	p.L417L	ZMYND17_uc001juc.2_3'UTR|ZMYND17_uc009xrh.2_Silent_p.L440L|ZMYND17_uc009xrg.2_Silent_p.L196L	NM_001024593	NP_001019764	Q4VC12	ZMY17_HUMAN	zinc finger, MYND domain containing 17	417							zinc ion binding			ovary(1)	1	Prostate(51;0.0119)					GTTCAGGTTTGAGGGACATGA	0.463													0	0	0	0.01441	0	51	72										C	75184443	G	C	75184443	2	2	47	1	0	0	0	0	0	0	0	1	17706	1277	45	1		1	ZMYND17	10	75184443	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	132982	75184443	60350304	165	13646										
SH3PXD2A	9644	broad.mit.edu	37	chr10	105361657	105361657	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atctggcagtaccaccagccAttagggttcctctccagaac	8	14	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:105361657A>G	uc001kxj.1	-	14	3374	c.3234T>C	c.(3232-3234)AAT>AAC	p.N1078N	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Silent_p.N913N|SH3PXD2A_uc010qqt.1_Silent_p.N955N|SH3PXD2A_uc009xxn.1_Silent_p.N913N|SH3PXD2A_uc010qqu.1_Silent_p.N1021N	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	1106	SH3 5.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ACCACCAGCCATTAGGGTTCC	0.552													0	0	0	0.007291	0	22	50										G	105361657	A	G	105361657	2	3	47	1	0	0	0	0	0	0	0	1	14256	214	8	5		5	SH3PXD2A	10	105361657	Silent	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	30177214	105361657	30173090	166	13647										
INPP5F	22876	broad.mit.edu	37	chr10	121580377	121580377	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcctcattgatgctactcacAgagacgtggatgtgctgtta	11	9	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:121580377A>G	uc001leo.2	+	16	2072	c.1906A>G	c.(1906-1908)AGA>GGA	p.R636G	INPP5F_uc001lep.2_Missense_Mutation_p.R26G	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	636							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TGCTACTCACAGAGACGTGGA	0.363													0	0	0	0.01441	0	44	87										G	121580377	A	G	121580377	3	3	47	1	0	0	0	0	1	0	0	0	7758	180	7	5	1968	5	INPP5F	10	121580377	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	16218720	121580377	13954370	167	13648										
ACADSB	36	broad.mit.edu	37	chr10	124800022	124800022	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cccagaatatggaggcacagGagcttcatttttatccactg	9	10	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr10:124800022G>C	uc001lhb.2	+	4	461	c.344G>C	c.(343-345)GGA>GCA	p.G115A	ACADSB_uc010qub.1_Missense_Mutation_p.G13A	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	115					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	GGAGGCACAGGAGCTTCATTT	0.368													0	0	0	0.00874	0	41	59										C	124800022	G	C	124800022	3	2	47	1	0	0	0	0	1	0	0	0	115	1174	41	1	358	1	ACADSB	10	124800022	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	3219645	124800022	10734725	168	13649										
C11orf16	56673	broad.mit.edu	37	chr11	8947287	8947287	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aaaagctgtgctgtgggctcCaactctggaagttctctggc	12	10	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:8947287C>T	uc001mhb.3	-	5	1051	c.927G>A	c.(925-927)TTG>TTA	p.L309L	C11orf16_uc001mhc.3_Silent_p.L309L	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	309										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		CTGTGGGCTCCAACTCTGGAA	0.577													0	0	0	0.01892	0	25	53										T	8947287	C	T	8947287	2	4	47	1	0	0	0	0	0	0	0	1	1631	593	21	2		2	C11orf16	11	8947287	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		8947287	126059229	169	13650										
SBF2	81846	broad.mit.edu	37	chr11	10022532	10022532	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgttggggaacttagaacttCcagtagctgagccgggagaa	14	8	0	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:10022532C>A	uc001mib.2	-	8	928	c.790G>T	c.(790-792)GAA>TAA	p.E264*	SBF2_uc001mif.3_Nonsense_Mutation_p.E20*	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	264	DENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CTTAGAACTTCCAGTAGCTGA	0.323													1	0	2.61681e-11	0.020292	2.77877e-11	13	29										A	10022532	C	A	10022532	4	1	47	1	0	0	0	0	0	1	0	0	13859	864	30	3	4891	3	SBF2	11	10022532	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1075245	10022532	124983984	170	13651										
AMPD3	272	broad.mit.edu	37	chr11	10483070	10483070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttctttgctagctgagatgCcgcggcagtttcccaagctg	11	11	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:10483070C>T	uc001mio.1	+	2	339	c.4C>T	c.(4-6)CCG>TCG	p.P2S	AMPD3_uc010rbz.1_5'UTR|AMPD3_uc001min.1_Missense_Mutation_p.P11S|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.P2S|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.P9S|AMPD3_uc009yfy.2_Missense_Mutation_p.P2S	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	2					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		AGCTGAGATGCCGCGGCAGTT	0.552													0	0	0	0.01441	0	83	120										T	10483070	C	T	10483070	3	4	47	1	0	0	0	0	1	0	0	0	587	739	26	2	57	2	AMPD3	11	10483070	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	460538	10483070	124523446	171	13652										
USH1C	10083	broad.mit.edu	37	chr11	17538984	17538984	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tccgtgcctccatccaggtcAtctgcgggctcgagctcagg	12	15	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:17538984A>G	uc001mnf.2	-	15	1357	c.1248T>C	c.(1246-1248)GAT>GAC	p.D416D	USH1C_uc001mne.2_Intron|USH1C_uc009yhb.2_Silent_p.D397D|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Silent_p.D380D	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	416					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CATCCAGGTCATCTGCGGGCT	0.627													0	0	0	0.004672	0	3	3										G	17538984	A	G	17538984	2	3	47	1	0	0	0	0	0	0	0	1	17031	214	8	5		5	USH1C	11	17538984	Silent	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	7055914	17538984	117467532	172	13653										
OR4C11	219429	broad.mit.edu	37	chr11	55371622	55371622	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcatccacaattaatctaggGgctgtggaagttgaaaagca	11	7	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:55371622G>T	uc010rii.1	-	1	228	c.228C>A	c.(226-228)GCC>GCA	p.A76A		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTAATCTAGGGGCTGTGGAAG	0.398													1	0	1.05635e-38	0.01441	1.19573e-38	68	67										T	55371622	G	T	55371622	2	4	47	1	0	0	0	0	0	0	0	1	11045	1219	43	4		4	OR4C11	11	55371622	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	37832638	55371622	79634894	173	13654										
OR5R1	219479	broad.mit.edu	37	chr11	56185264	56185264	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aaccaggaagctgtatatatAtggaactgccaccagttgaa	9	8	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:56185264A>G	uc010rji.1	-	1	445	c.445T>C	c.(445-447)TAT>CAT	p.Y149H		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CTGTATATATATGGAACTGCC	0.453													0	0	0	0.021022	0	39	81										G	56185264	A	G	56185264	3	3	47	1	0	0	0	0	1	0	0	0	11180	449	16	5	531	5	OR5R1	11	56185264	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	813642	56185264	78821252	174	13655										
OR6Q1	219952	broad.mit.edu	37	chr11	57799250	57799250	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctcctccatcaacttcaacAaggtggtatctgtcttctac	5	14	5	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:57799250A>C	uc010rjz.1	+	1	826	c.826A>C	c.(826-828)AAG>CAG	p.K276Q	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CAACTTCAACAAGGTGGTATC	0.488													0	0	0	0.004656	0	25	161										C	57799250	A	C	57799250	3	2	47	1	0	0	0	0	1	0	0	0	11208	131	5	5	828	5	OR6Q1	11	57799250	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	1613986	57799250	77207266	175	13656										
OR9Q1	219956	broad.mit.edu	37	chr11	57947275	57947275	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctcttggccctcatggcctAtgaccgctacttggctgtgt	10	14	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:57947275A>G	uc001nmj.2	+	3	675	c.359A>G	c.(358-360)TAT>TGT	p.Y120C		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				CTCATGGCCTATGACCGCTAC	0.552													0	0	0	0.016522	0	20	55										G	57947275	A	G	57947275	3	3	47	1	0	0	0	0	1	0	0	0	11255	449	16	5	361	5	OR9Q1	11	57947275	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	148025	57947275	77059241	176	13657										
NXF1	10482	broad.mit.edu	37	chr11	62560155	62560157	+	In_Frame_Del	DEL	GTT	GTT	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcagatctggtgtagtcccaGttgttgtcctgaaggcacct							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:62560155_62560157delGTT	uc001nvf.1	-	20	1913_1915	c.1777_1779delAAC	c.(1777-1779)AACdel	p.N593del	TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_3'UTR	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	593	TAP-C.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TGTAGTCCCAGTTGTTGTCCTGA	0.384																		22	67	---	---								-	62560157	GTT	-	62560155	7	5	47	1	0	1	0	1	0	0	0	0	10782	1020	36	0	88	0	NXF1	11	62560155	In_Frame_Del	DEL	GTT	TCGA-DK-A1AD-01A-11D-A13W-08	4612880	62560155	72446361	177	13658										
FZD4	8322	broad.mit.edu	37	chr11	86663440	86663440	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tctcttgactgaaagacacaTgccgccgcatgggccaatgg	11	12	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:86663440T>G	uc001pce.2	-	2	664	c.358A>C	c.(358-360)ATG>CTG	p.M120L	PRSS23_uc001pcc.1_RNA	NM_012193	NP_036325	Q9ULV1	FZD4_HUMAN	frizzled 4 precursor	120	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			large_intestine(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAAAGACACATGCCGCCGCAT	0.478													0	0	0	0.01441	0	59	101										G	86663440	T	G	86663440	3	3	47	1	0	0	0	0	1	0	0	0	6132	1464	51	5	1259	5	FZD4	11	86663440	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	24103285	86663440	48343076	178	13659										
ENDOD1	23052	broad.mit.edu	37	chr11	94861970	94861970	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcaagcacacccgggacagtGacatcatagaagatgtgatg	11	9	2	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:94861970G>A	uc001pfh.2	+	2	805	c.730G>A	c.(730-732)GAC>AAC	p.D244N		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	244						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				CCGGGACAGTGACATCATAGA	0.498													0	0	0	0.021523	0	23	30										A	94861970	G	A	94861970	3	1	47	1	0	0	0	0	1	0	0	0	5114	1290	45	1	736	1	ENDOD1	11	94861970	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	8198530	94861970	40144546	179	13660										
TRPC6	7225	broad.mit.edu	37	chr11	101374954	101374954	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgcacttgcagaaataatcaTgaggccgttcaatcctagca	8	10	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:101374954T>C	uc001pgk.3	-	2	1171	c.746A>G	c.(745-747)CAT>CGT	p.H249R	TRPC6_uc009ywy.2_Missense_Mutation_p.H249R|TRPC6_uc009ywz.1_Missense_Mutation_p.H249R	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	249	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GAAATAATCATGAGGCCGTTC	0.473													0	0	0	0.003163	0	16	120										C	101374954	T	C	101374954	3	2	47	1	0	0	0	0	1	0	0	0	16580	1464	51	5	2097	5	TRPC6	11	101374954	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	6512984	101374954	33631562	180	13661										
NCAM1	4684	broad.mit.edu	37	chr11	113102975	113102975	+	Frame_Shift_Del	DEL	C	C	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctgcgaggtatttgcctatCccagtgccacgatctcatgg							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:113102975delC	uc009yyq.1	+	12	1742	c.1048delC	c.(1048-1050)CCCfs	p.P350fs		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	442	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ATTTGCCTATCCCAGTGCCAC	0.517																		17	36	---	---								-	113102975	C	-	113102975	7	5	47	1	0	1	0	1	0	0	0	0	10202	855	30	0	1367	0	NCAM1	11	113102975	Frame_Shift_Del	DEL	C	TCGA-DK-A1AD-01A-11D-A13W-08	11728021	113102975	21903541	181	13662										
PVRL1	5818	broad.mit.edu	37	chr11	119535753	119535753	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttctcgtcgtctgagtcgtCggggtactgcaggttctgtg	14	10	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:119535753C>A	uc001pwv.2	-	6	1430	c.1258G>T	c.(1258-1260)GAC>TAC	p.D420Y	PVRL1_uc001pwu.1_Intron	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	420	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		TCTGAGTCGTCGGGGTACTGC	0.547													1	0	1.5548e-18	0.005443	1.68394e-18	26	50										A	119535753	C	A	119535753	3	1	47	1	0	0	0	0	1	0	0	0	12839	884	31	3	685	3	PVRL1	11	119535753	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	6432778	119535753	15470763	182	13663										
TP53AIP1	63970	broad.mit.edu	37	chr11	128807621	128807621	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccattcggaggcatcaccgaGaggttctggtctcccctgcc	11	15	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr11:128807621G>A	uc001qey.2	-	2	303	c.93C>T	c.(91-93)CTC>CTT	p.L31L	TP53AIP1_uc001qex.2_Silent_p.L31L|TP53AIP1_uc009zcm.1_RNA			Q9HCN2	TPIP1_HUMAN	RecName: Full=p53-regulated apoptosis-inducing protein 1;          Short=p53AIP1;	31					apoptosis	mitochondrion				lung(1)	1						GCATCACCGAGAGGTTCTGGT	0.622													0	0	0	0.008871	0	17	44										A	128807621	G	A	128807621	2	1	47	1	0	0	0	0	0	0	0	1	16379	929	33	1		1	TP53AIP1	11	128807621	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	9271868	128807621	6198895	183	13664										
RIMKLB	57494	broad.mit.edu	37	chr12	8926198	8926198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccgtggtgtccactgccagtGagactagtgagccggagctg	15	11	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:8926198G>A	uc001quu.2	+	6	1230	c.979G>A	c.(979-981)GAG>AAG	p.E327K	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Missense_Mutation_p.E327K|RIMKLB_uc010sgl.1_Missense_Mutation_p.E327K|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	327					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						CACTGCCAGTGAGACTAGTGA	0.597													0	0	0	0.01441	0	45	35										A	8926198	G	A	8926198	3	1	47	1	0	0	0	0	1	0	0	0	13366	1291	45	1	997	1	RIMKLB	12	8926198	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		8926198	124925697	184	13665										
TAS2R50	259296	broad.mit.edu	37	chr12	11138589	11138589	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aatctgacacaaaatcaaaaGaaaggtgtgttttagcttct	7	6	3	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:11138589G>C	uc001qzl.2	-	1	923	c.871C>G	c.(871-873)CTT>GTT	p.L291V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	291	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(2)	2						AAAATCAAAAGAAAGGTGTGT	0.398													0	0	0	0.009718	0	42	126										C	11138589	G	C	11138589	3	2	47	1	0	0	0	0	1	0	0	0	15581	942	33	1	32	1	TAS2R50	12	11138589	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	2212391	11138589	122713306	185	13666										
H2AFJ	55766	broad.mit.edu	37	chr12	14927572	14927572	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtgtacctggcggcggtgttGgagtaccttacggcggagat	17	8	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:14927572G>A	uc009zia.2	+	1	303	c.168G>A	c.(166-168)TTG>TTA	p.L56L	H2AFJ_uc001rch.3_RNA	NM_177925	NP_808760	Q9BTM1	H2AJ_HUMAN	H2A histone family, member J	56					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1						CGGCGGTGTTGGAGTACCTTA	0.667													0	0	0	0.00499	0	14	44										A	14927572	G	A	14927572	2	1	47	1	0	0	0	0	0	0	0	1	6926	1339	47	2		2	H2AFJ	12	14927572	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	3788983	14927572	118924323	186	13667										
OVCH1	341350	broad.mit.edu	37	chr12	29630357	29630357	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagaaacaaatggaaccatgGcctcactggtctctgccagc	9	13	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:29630357G>T	uc001rix.1	-	11	1163	c.1163C>A	c.(1162-1164)GCC>GAC	p.A388D		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	388	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGGAACCATGGCCTCACTGGT	0.423													1	0	3.07184e-27	0.01441	3.40619e-27	66	51										T	29630357	G	T	29630357	3	4	47	1	0	0	0	0	1	0	0	0	11323	1203	42	4	2313	4	OVCH1	12	29630357	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	14702785	29630357	104221538	187	13668										
IPO8	10526	broad.mit.edu	37	chr12	30829450	30829450	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acaggaggaacggtcctgtcGataatagttcggaagatctc	12	8	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:30829450G>A	uc001rjd.2	-	6	881	c.711C>T	c.(709-711)ATC>ATT	p.I237I	IPO8_uc010sjt.1_Silent_p.I32I	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	237					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CGGTCCTGTCGATAATAGTTC	0.428													0	0	0	0.012319	0	20	75										A	30829450	G	A	30829450	2	1	47	1	0	0	0	0	0	0	0	1	7798	1048	37	1		1	IPO8	12	30829450	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1199093	30829450	103022445	188	13669										
CPNE8	144402	broad.mit.edu	37	chr12	39079368	39079368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttcagactcctgtaataagCctccatgaccccctcaatgc	5	15	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:39079368C>T	uc001rls.1	-	16	1279	c.1195G>A	c.(1195-1197)GCT>ACT	p.A399T	CPNE8_uc001rlr.1_Missense_Mutation_p.A58T	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	399	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CTGTAATAAGCCTCCATGACC	0.398													0	0	0	0.006122	0	18	228										T	39079368	C	T	39079368	3	4	47	1	0	0	0	0	1	0	0	0	3818	739	26	2	519	2	CPNE8	12	39079368	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	8249918	39079368	94772527	189	13670										
KIF21A	55605	broad.mit.edu	37	chr12	39730987	39730987	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttctcttgttcttctttcaTttgtttcattaggcgaacct	5	9	5	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:39730987T>C	uc001rly.2	-	17	2475	c.2329A>G	c.(2329-2331)ATG>GTG	p.M777V	KIF21A_uc001rlw.2_Missense_Mutation_p.M94V|KIF21A_uc001rlx.2_Missense_Mutation_p.M764V|KIF21A_uc001rlz.2_Missense_Mutation_p.M764V|KIF21A_uc010skl.1_Missense_Mutation_p.M764V	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	777					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TCTTCTTTCATTTGTTTCATT	0.348													0	0	0	0.010771	0	44	93										C	39730987	T	C	39730987	3	2	47	1	0	0	0	0	1	0	0	0	8288	1493	52	5	2783	5	KIF21A	12	39730987	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	651619	39730987	94120908	190	13671										
PDZRN4	29951	broad.mit.edu	37	chr12	41967486	41967486	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcatgatgcgaagcaggttaGagtgtctcaaggagagccct	13	8	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:41967486G>A	uc010skn.1	+	10	2376	c.2308G>A	c.(2308-2310)GAG>AAG	p.E770K	PDZRN4_uc001rmq.3_Missense_Mutation_p.E711K|PDZRN4_uc009zjz.2_Missense_Mutation_p.E709K|PDZRN4_uc001rmr.2_Missense_Mutation_p.E596K	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	969							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AAGCAGGTTAGAGTGTCTCAA	0.498													0	0	0	0.020292	0	14	25										A	41967486	G	A	41967486	3	1	47	1	0	0	0	0	1	0	0	0	11710	943	33	1	3016	1	PDZRN4	12	41967486	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	2236499	41967486	91884409	191	13672										
MLL2	8085	broad.mit.edu	37	chr12	49427929	49427933	+	Frame_Shift_Del	DEL	CGGCC	CGGCC	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	catcagcttctgggaactcaCggccagcttttttggcagtg							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			CGGCC	-	CGGCC	CGGCC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:49427929_49427933delCGGCC	uc001rta.3	-	38	10657_10661	c.10657_10661delGGCCG	c.(10657-10662)GGCCGTfs	p.G3553fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3553_3554	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGGAACTCACGGCCAGCTTTTTTG	0.541			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								38	60	---	---								-	49427933	CGGCC	-	49427929	7	5	47	1	0	1	0	1	0	0	0	0	9621	536	19	0	6020	0	MLL2	12	49427929	Frame_Shift_Del	DEL	CGGCC	TCGA-DK-A1AD-01A-11D-A13W-08	7460443	49427929	84423966	192	13673										
RACGAP1	29127	broad.mit.edu	37	chr12	50384549	50384549	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttgagaagctgatgttcagGagtggtcacaggtcccagta	13	8	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:50384549G>A	uc001rvt.2	-	18	2051	c.1741C>T	c.(1741-1743)CCT>TCT	p.P581S	RACGAP1_uc009zlm.1_Missense_Mutation_p.P581S|RACGAP1_uc001rvs.2_Missense_Mutation_p.P581S|RACGAP1_uc001rvu.2_Missense_Mutation_p.P581S	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	581					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						TGATGTTCAGGAGTGGTCACA	0.438													0	0	0	0.008361	0	28	87										A	50384549	G	A	50384549	3	1	47	1	0	0	0	0	1	0	0	0	12977	1174	41	1	165	1	RACGAP1	12	50384549	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	956620	50384549	83467346	193	13674										
DIP2B	57609	broad.mit.edu	37	chr12	51090911	51090911	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggactgaagcctgaggccatCtgtccgtgcgccacgtctgc	13	14	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:51090911C>A	uc001rwv.2	+	17	2157	c.2001C>A	c.(1999-2001)ATC>ATA	p.I667I	DIP2B_uc009zlt.2_Silent_p.I97I	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	667						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CTGAGGCCATCTGTCCGTGCG	0.498													1	0	2.0095e-06	0.001984	2.06005e-06	7	29										A	51090911	C	A	51090911	2	1	47	1	0	0	0	0	0	0	0	1	4528	903	32	3		3	DIP2B	12	51090911	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	706362	51090911	82760984	194	13675										
ESPL1	9700	broad.mit.edu	37	chr12	53676162	53676162	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgcagctggtggcagcttacCttagcctcccgtcaaacaac	9	14	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:53676162C>G	uc001sck.2	+	14	2825	c.2734C>G	c.(2734-2736)CTT>GTT	p.L912V	ESPL1_uc001scj.2_Missense_Mutation_p.L587V|ESPL1_uc010soe.1_Missense_Mutation_p.L123V	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	912					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GGCAGCTTACCTTAGCCTCCC	0.577													0	0	0	0.014323	0	22	64										G	53676162	C	G	53676162	3	3	47	1	0	0	0	0	1	0	0	0	5253	681	24	4	2784	4	ESPL1	12	53676162	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2585251	53676162	80175733	195	13676										
TPH2	121278	broad.mit.edu	37	chr12	72388270	72388270	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccactacttgcggatcctaaGtttgctcagttttcacaaga	7	11	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:72388270G>A	uc009zrw.1	+	8	1134	c.993G>A	c.(991-993)AAG>AAA	p.K331K	TPH2_uc001swy.2_Silent_p.K241K	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	331					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	CGGATCCTAAGTTTGCTCAGT	0.403													0	0	0	0.015359	0	31	132										A	72388270	G	A	72388270	2	1	47	1	0	0	0	0	0	0	0	1	16399	1020	36	2		2	TPH2	12	72388270	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	18712108	72388270	61463625	196	13677										
PITPNM2	57605	broad.mit.edu	37	chr12	123471235	123471235	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagttggccttgtgccgcagCgggtcatgcaccaggccgtc	14	13	1	0	rs147680163	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr12:123471235C>T	uc001uej.1	-	23	3694	c.3555G>A	c.(3553-3555)CCG>CCA	p.P1185P	PITPNM2_uc001uek.1_Silent_p.P1179P	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	1185					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGTGCCGCAGCGGGTCATGCA	0.687													0	0	0	0.009096	0	3	19										T	123471235	C	T	123471235	2	4	47	1	0	0	0	0	0	0	0	1	11951	755	27	2		2	PITPNM2	12	123471235	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	51082965	123471235	10380660	197	13678										
KATNAL1	84056	broad.mit.edu	37	chr13	30829724	30829724	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctcagaggtcttacttctcGattgggacgcctgatctgag	11	11	4	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr13:30829724G>A	uc001uss.2	-	4	453	c.352C>T	c.(352-354)CGA>TGA	p.R118*	KATNAL1_uc001ust.2_Nonsense_Mutation_p.R118*	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	118						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		CTTACTTCTCGATTGGGACGC	0.388													0	0	0	0.01441	0	176	78										A	30829724	G	A	30829724	4	1	47	1	0	0	0	0	0	1	0	0	7985	1066	37	1	1152	1	KATNAL1	13	30829724	Nonsense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		30829724	84340154	198	13679										
BRCA2	675	broad.mit.edu	37	chr13	32929379	32929379	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttaacaaaaacaactccaaTcaagcagtagctgtaacttt	4	9	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr13:32929379T>C	uc001uub.1	+	14	7616	c.7389T>C	c.(7387-7389)AAT>AAC	p.N2463N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2463	Interaction with FANCD2.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ACAACTCCAATCAAGCAGTAG	0.323			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008871	0	20	37										C	32929379	T	C	32929379	2	2	47	1	0	0	0	0	0	0	0	1	1499	1432	50	5		5	BRCA2	13	32929379	Silent	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	2099655	32929379	82240499	199	13680										
TDRD3	81550	broad.mit.edu	37	chr13	61057916	61057916	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	attttttccgcagagcttatCaaaacacaatagaagcaata	5	8	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr13:61057916C>G	uc001via.2	+	6	1012	c.224C>G	c.(223-225)TCA>TGA	p.S75*	TDRD3_uc010aef.2_Translation_Start_Site|TDRD3_uc001vhz.3_Nonsense_Mutation_p.S75*|TDRD3_uc010aeg.2_Nonsense_Mutation_p.S168*|TDRD3_uc001vib.3_Nonsense_Mutation_p.S75*	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	75					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CAGAGCTTATCAAAACACAAT	0.348													0	0	0	0.01441	0	46	128										G	61057916	C	G	61057916	4	3	47	1	0	0	0	0	0	1	0	0	15729	838	29	1	525	1	TDRD3	13	61057916	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	28128537	61057916	54111962	200	13681										
FAM179B	23116	broad.mit.edu	37	chr14	45432544	45432544	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctctgccctgaggagacactAcaatcgccgcctggagtccc	10	16	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:45432544A>G	uc001wvv.2	+	1	1129	c.920A>G	c.(919-921)TAC>TGC	p.Y307C	FAM179B_uc001wvw.2_Missense_Mutation_p.Y307C|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.Y307C|FAM179B_uc001wvu.2_Missense_Mutation_p.Y307C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	307							binding			skin(2)|upper_aerodigestive_tract(1)	3						AGGAGACACTACAATCGCCGC	0.502													0	0	0	0.019004	0	33	64										G	45432544	A	G	45432544	3	3	47	1	0	0	0	0	1	0	0	0	5506	391	14	5	922	5	FAM179B	14	45432544	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08		45432544	61916996	201	13682										
FANCM	57697	broad.mit.edu	37	chr14	45623913	45623913	+	Frame_Shift_Del	DEL	A	A	-													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tctgaagggatgacacggtcAaaaaatgaacttggccgaaa							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:45623913delA	uc001wwd.3	+	7	1296	c.1197delA	c.(1195-1197)TCAfs	p.S399fs	FANCM_uc001wwc.2_Frame_Shift_Del_p.S399fs|FANCM_uc010anf.2_Frame_Shift_Del_p.S373fs|FANCM_uc001wwe.3_Frame_Shift_Del_p.S4fs	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	399					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TGACACGGTCAAAAAATGAAC	0.269								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia									34	39	---	---								-	45623913	A	-	45623913	7	5	47	1	0	1	0	1	0	0	0	0	5671	117	5	0	1223	0	FANCM	14	45623913	Frame_Shift_Del	DEL	A	TCGA-DK-A1AD-01A-11D-A13W-08	191369	45623913	61725627	202	13683										
PTGER2	5732	broad.mit.edu	37	chr14	52781858	52781858	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acgggcggaccgcttacctgCagctgtacgccaccctgctg	12	16	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:52781858C>G	uc001wzr.2	+	1	843	c.592C>G	c.(592-594)CAG>GAG	p.Q198E		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	198	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CGCTTACCTGCAGCTGTACGC	0.627													0	0	0	0.014758	0	3	31										G	52781858	C	G	52781858	3	3	47	1	0	0	0	0	1	0	0	0	12743	711	25	4	594	4	PTGER2	14	52781858	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7157945	52781858	54567682	203	13684										
C14orf174	161394	broad.mit.edu	37	chr14	77845304	77845304	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcatgaaaaggaagttgtaGatttgtcccaagagttgaag	11	4	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:77845304G>C	uc001xtq.1	+	1	1543	c.1543G>C	c.(1543-1545)GAT>CAT	p.D515H	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	515											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GGAAGTTGTAGATTTGTCCCA	0.413													0	0	0	0.005524	0	37	67										C	77845304	G	C	77845304	3	2	47	1	0	0	0	0	1	0	0	0	1759	942	33	1	1545	1	C14orf174	14	77845304	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	25063446	77845304	29504236	204	13685										
GPR68	8111	broad.mit.edu	37	chr14	91700947	91700947	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gaagtagatgctggtcagcaGctccttggcccagatgacca	12	11	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:91700947G>T	uc001xzg.2	-	2	789	c.448C>A	c.(448-450)CTG>ATG	p.L150M	GPR68_uc001xzh.2_Missense_Mutation_p.L160M	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	150	Helical; Name=4; (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		CTGGTCAGCAGCTCCTTGGCC	0.637													1	0	4.68919e-08	0.008291	4.85294e-08	11	15										T	91700947	G	T	91700947	3	4	47	1	0	0	0	0	1	0	0	0	6707	962	34	4	653	4	GPR68	14	91700947	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	13855643	91700947	15648593	205	13686										
ATG2B	55102	broad.mit.edu	37	chr14	96757944	96757944	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taaattcacttacccatgtcGataggaaagcctcttgagct	7	10	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr14:96757944G>A	uc001yfi.2	-	38	5937	c.5572C>T	c.(5572-5574)CGA>TGA	p.R1858*		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1858										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TACCCATGTCGATAGGAAAGC	0.348													0	0	0	0.011902	0	41	180										A	96757944	G	A	96757944	4	1	47	1	0	0	0	0	0	1	0	0	1094	1066	37	1	684	1	ATG2B	14	96757944	Nonsense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	5056997	96757944	10591596	206	13687										
MGA	23269	broad.mit.edu	37	chr15	41961492	41961492	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tatctcctgtggataaccatCgttataagtggaatggtcgt	10	7	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:41961492C>T	uc001zog.1	+	2	491	c.400C>T	c.(400-402)CGT>TGT	p.R134C	MGA_uc010ucy.1_Missense_Mutation_p.R134C|MGA_uc010ucz.1_Missense_Mutation_p.R134C	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	134	T-box.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGATAACCATCGTTATAAGTG	0.418													0	0	0	0.01441	0	130	245										T	41961492	C	T	41961492	3	4	47	1	0	0	0	0	1	0	0	0	9540	884	31	1	402	1	MGA	15	41961492	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		41961492	60569900	207	13688										
FBN1	2200	broad.mit.edu	37	chr15	48776085	48776085	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cacctgtactctccagggatAtttgtgcactgaccaccatc	7	14	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:48776085A>T	uc001zwx.1	-	31	4096	c.3768T>A	c.(3766-3768)AAT>AAA	p.N1256K		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1256	EGF-like 20; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CTCCAGGGATATTTGTGCACT	0.398													0	0	0	0.01441	0	57	66										T	48776085	A	T	48776085	3	4	47	1	0	0	0	0	1	0	0	0	5702	446	16	5	4991	5	FBN1	15	48776085	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	6814593	48776085	53755307	208	13689										
KIAA1370	56204	broad.mit.edu	37	chr15	52901214	52901214	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tttatcaattccattgctcaTttcttgctccttgaatctgc	4	11	4	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:52901214T>C	uc002acg.3	-	6	2050	c.1897A>G	c.(1897-1899)ATG>GTG	p.M633V	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.M545V|KIAA1370_uc010ugf.1_Missense_Mutation_p.M640V	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	633											0				all cancers(107;0.0803)		CCATTGCTCATTTCTTGCTCC	0.303													0	0	0	0.01441	0	44	170										C	52901214	T	C	52901214	3	2	47	1	0	0	0	0	1	0	0	0	8226	1493	52	5	1365	5	KIAA1370	15	52901214	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	4125129	52901214	49630178	209	13690										
UNC13C	440279	broad.mit.edu	37	chr15	54306851	54306851	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tctcctgtcatcttcggaccGggagctatggcagaggaaac	12	11	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:54306851G>T	uc002ack.2	+	1	1751	c.1751G>T	c.(1750-1752)CGG>CTG	p.R584L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	584					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCTTCGGACCGGGAGCTATGG	0.453													1	0	1.87028e-06	0.012319	1.92338e-06	21	48										T	54306851	G	T	54306851	3	4	47	1	0	0	0	0	1	0	0	0	16983	1116	39	4	1753	4	UNC13C	15	54306851	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1405637	54306851	48224541	210	13691										
RPLP1	6176	broad.mit.edu	37	chr15	69746006	69746006	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gaggataagatcaatgccctCattaaagcagccggtgtaaa	10	8	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:69746006C>T	uc002asd.1	+	2	222	c.93C>T	c.(91-93)CTC>CTT	p.L31L	RPLP1_uc002ase.1_Intron	NM_001003	NP_000994	P05386	RLA1_HUMAN	ribosomal protein P1 isoform 1	31					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						TCAATGCCCTCATTAAAGCAG	0.418													0	0	0	0.01441	0	68	69										T	69746006	C	T	69746006	2	4	47	1	0	0	0	0	0	0	0	1	13605	813	29	1		1	RPLP1	15	69746006	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	15439155	69746006	32785386	211	13692										
GRAMD2	196996	broad.mit.edu	37	chr15	72459414	72459414	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gttttttgatcatttgcacaGacaccacaggaatgaccacc	7	11	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:72459414G>A	uc002atq.2	-	6	416	c.392C>T	c.(391-393)TCT>TTT	p.S131F	GRAMD2_uc010bis.2_Missense_Mutation_p.S131F	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	131	GRAM.					integral to membrane					0						CATTTGCACAGACACCACAGG	0.567													0	0	0	0.004482	0	9	45										A	72459414	G	A	72459414	3	1	47	1	0	0	0	0	1	0	0	0	6750	942	33	1	700	1	GRAMD2	15	72459414	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	2713408	72459414	30071978	212	13693										
SCAPER	49855	broad.mit.edu	37	chr15	76726455	76726455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctcgattgttaaaaggatcaCcttgtgagggtttgtttttc	10	6	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr15:76726455C>T	uc002bby.2	-	25	3334	c.3275G>A	c.(3274-3276)GGT>GAT	p.G1092D	SCAPER_uc010bkr.2_Missense_Mutation_p.G400D|SCAPER_uc002bbx.2_Missense_Mutation_p.G846D|SCAPER_uc002bbz.1_Missense_Mutation_p.G963D	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1091						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AAAAGGATCACCTTGTGAGGG	0.373													0	0	0	0.00499	0	18	39										T	76726455	C	T	76726455	3	4	47	1	0	0	0	0	1	0	0	0	13878	507	18	2	955	2	SCAPER	15	76726455	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	4267041	76726455	25804937	213	13694										
CREBBP	1387	broad.mit.edu	37	chr16	3786148	3786148	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggccagaaatcaccttcaaaAtagggcagttccttggcact	9	11	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:3786148A>C	uc002cvv.2	-	28	4821	c.4617T>G	c.(4615-4617)TAT>TAG	p.Y1539*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.Y1501*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1539	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CACCTTCAAAATAGGGCAGTT	0.478			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.01441	0	80	63										C	3786148	A	C	3786148	4	2	47	1	0	0	0	0	0	1	0	0	3861	108	4	5	2727	5	CREBBP	16	3786148	Nonsense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08		3786148	86568605	214	13695										
CREBBP	1387	broad.mit.edu	37	chr16	3828045	3828045	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aggttgtgcctgtggaatcaCagggggctgagcccccgggg	18	10	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:3828045C>G	uc002cvv.2	-	10	2284	c.2080G>C	c.(2080-2082)GTG>CTG	p.V694L	CREBBP_uc002cvw.2_Missense_Mutation_p.V656L	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	694					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGTGGAATCACAGGGGGCTGA	0.502			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.012213	0	31	148										G	3828045	C	G	3828045	3	3	47	1	0	0	0	0	1	0	0	0	3861	478	17	4	5336	4	CREBBP	16	3828045	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	41897	3828045	86526708	215	13696										
CIITA	4261	broad.mit.edu	37	chr16	10971204	10971204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cacaatgcgttgcctggctcCacgccctgctgggtcctacc	10	17	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:10971204C>T	uc002dai.3	+	1	150	c.17C>T	c.(16-18)CCA>CTA	p.P6L	CIITA_uc002daj.3_Missense_Mutation_p.P6L|CIITA_uc002dak.3_Missense_Mutation_p.P6L|CIITA_uc002dag.2_Missense_Mutation_p.P6L|CIITA_uc002dah.2_Missense_Mutation_p.P6L|CIITA_uc010bup.1_Missense_Mutation_p.P6L	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	6					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TGCCTGGCTCCACGCCCTGCT	0.597			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								0	0	0	0.001984	0	7	6										T	10971204	C	T	10971204	3	4	47	1	0	0	0	0	1	0	0	0	3428	594	21	2	19	2	CIITA	16	10971204	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7143159	10971204	79383549	216	13697										
MYST1	84148	broad.mit.edu	37	chr16	31141847	31141847	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgtctgacctgggcaagctCagctaccgcagctactggtc	11	14	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:31141847C>T	uc002eay.2	+	9	1095	c.1077C>T	c.(1075-1077)CTC>CTT	p.L359L	MYST1_uc002eax.2_Silent_p.L359L|MYST1_uc002eaz.2_Silent_p.L201L|MYST1_uc002eba.2_Silent_p.L143L|MYST1_uc002ebb.2_RNA	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	359					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						TGGGCAAGCTCAGCTACCGCA	0.612													0	0	0	0.013537	0	8	15										T	31141847	C	T	31141847	2	4	47	1	0	0	0	0	0	0	0	1	10102	813	29	1		1	MYST1	16	31141847	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	20170643	31141847	59212906	217	13698										
CA7	766	broad.mit.edu	37	chr16	66881069	66881069	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tatgaggcctgcatgtccctCagcatcaccaacaatggcca	8	14	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:66881069C>T	uc002eqi.2	+	2	286	c.177C>T	c.(175-177)CTC>CTT	p.L59L	uc002eqh.2_Intron|CA7_uc002eqj.2_Silent_p.L3L	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	59					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GCATGTCCCTCAGCATCACCA	0.572													0	0	0	0.00499	0	17	20										T	66881069	C	T	66881069	2	4	47	1	0	0	0	0	0	0	0	1	2522	813	29	1		1	CA7	16	66881069	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	35739222	66881069	23473684	218	13699										
PKD1L2	114780	broad.mit.edu	37	chr16	81161440	81161440	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tacacagtgagtttgccccaGatgggatacccttgacgttg	11	10	0	3	rs117399993	by1000genomes	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr16:81161440G>A	uc002fgh.1	-	38	6276	c.6276C>T	c.(6274-6276)ATC>ATT	p.I2092I	PKD1L2_uc002fgf.1_5'UTR|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2092	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTTGCCCCAGATGGGATACC	0.547													0	0	0	0.010729	0	11	38										A	81161440	G	A	81161440	2	1	47	1	0	0	0	0	0	0	0	1	11965	942	33	1		1	PKD1L2	16	81161440	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	14280371	81161440	9193313	219	13700										
ABR	29	broad.mit.edu	37	chr17	1003885	1003885	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gactgtactcaccagcaacaGggcttccagctggttaatgt	10	11	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:1003885G>A	uc002fsd.2	-	3	447	c.337C>T	c.(337-339)CTG>TTG	p.L113L	ABR_uc002fse.2_Silent_p.L67L|ABR_uc002fsg.2_Silent_p.L76L|ABR_uc010cjq.1_Silent_p.L125L	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	113	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		ACCAGCAACAGGGCTTCCAGC	0.572													0	0	0	0.00632	0	29	20										A	1003885	G	A	1003885	2	1	47	1	0	0	0	0	0	0	0	1	99	991	35	2		2	ABR	17	1003885	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		1003885	80191325	220	13701										
ABR	29	broad.mit.edu	37	chr17	1003907	1003907	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcttccagctggttaatgtaGatctcttcgctggccaagaa	10	10	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:1003907G>A	uc002fsd.2	-	3	425	c.315C>T	c.(313-315)ATC>ATT	p.I105I	ABR_uc002fse.2_Silent_p.I59I|ABR_uc002fsg.2_Silent_p.I68I|ABR_uc010cjq.1_Silent_p.I117I	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	105	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GGTTAATGTAGATCTCTTCGC	0.582													0	0	0	0.010771	0	45	22										A	1003907	G	A	1003907	2	1	47	1	0	0	0	0	0	0	0	1	99	932	33	1		1	ABR	17	1003907	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	22	1003907	80191303	221	13702										
TP53	7157	broad.mit.edu	37	chr17	7578475	7578475	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgcggacgcgggtgccgggcGggggtgtggaatcaacccac	19	12	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:7578475G>A	uc002gim.2	-	5	649	c.455C>T	c.(454-456)CCG>CTG	p.P152L	TP53_uc002gig.1_Missense_Mutation_p.P152L|TP53_uc002gih.2_Missense_Mutation_p.P152L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P20L|TP53_uc010cng.1_Missense_Mutation_p.P20L|TP53_uc002gii.1_Missense_Mutation_p.P20L|TP53_uc010cnh.1_Missense_Mutation_p.P152L|TP53_uc010cni.1_Missense_Mutation_p.P152L|TP53_uc002gij.2_Missense_Mutation_p.P152L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P59L|TP53_uc002gio.2_Missense_Mutation_p.P20L|TP53_uc010vug.1_Missense_Mutation_p.P113L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	152	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> T (in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> Q (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P152L(57)|p.P152S(21)|p.P152fs*18(17)|p.P152T(7)|p.0?(7)|p.P152fs*29(5)|p.P152P(5)|p.P152Q(4)|p.P153fs*28(4)|p.P152fs*14(4)|p.P152fs*28(3)|p.P152R(3)|p.T150fs*16(3)|p.P152A(2)|p.P153fs*16(1)|p.P151_V173del23(1)|p.P152_P153del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152_P153insXXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGCCGGGCGGGGGTGTGGA	0.612		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00623	0	35	5										A	7578475	G	A	7578475	3	1	47	1	0	0	0	0	1	0	0	0	16378	1116	39	2	843	2	TP53	17	7578475	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	6574568	7578475	73616735	222	13703										
MYH13	8735	broad.mit.edu	37	chr17	10206521	10206521	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcctgtgcttaccgcctcctCagcctgcctcttgtaagact	7	16	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:10206521C>T	uc002gmk.1	-	39	5749	c.5659G>A	c.(5659-5661)GAG>AAG	p.E1887K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1887	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						ACCGCCTCCTCAGCCTGCCTC	0.592													0	0	0	0.021022	0	38	42										T	10206521	C	T	10206521	3	4	47	1	0	0	0	0	1	0	0	0	10032	835	29	1	169	1	MYH13	17	10206521	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2628046	10206521	70988689	223	13704										
SLC47A1	55244	broad.mit.edu	37	chr17	19480737	19480737	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgccaagaagaacctttgccGgaacatccacaggacggcgc	11	14	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:19480737G>A	uc002gvy.1	+	17	1670	c.1584G>A	c.(1582-1584)CCG>CCA	p.P528P	SLC47A1_uc002gvx.2_Silent_p.P528P|SLC47A1_uc010vyz.1_3'UTR|SLC47A1_uc010cqp.1_Silent_p.P226P|SLC47A1_uc010cqq.1_Silent_p.P274P|SLC47A1_uc010vza.1_Silent_p.P240P|SLC47A1_uc010vzb.1_Silent_p.P203P|SLC47A1_uc010vzc.1_Silent_p.P200P	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	528	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AACCTTTGCCGGAACATCCAC	0.532													0	0	0	0.006999	0	38	157										A	19480737	G	A	19480737	2	1	47	1	0	0	0	0	0	0	0	1	14647	1103	39	2		2	SLC47A1	17	19480737	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	9274216	19480737	61714473	224	13705										
CPD	1362	broad.mit.edu	37	chr17	28712233	28712233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagatggaatcacaaacggcGcacattggtatgatgtggaa	12	6	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:28712233G>A	uc002hfb.1	+	2	988	c.973G>A	c.(973-975)GCA>ACA	p.A325T	CPD_uc010wbo.1_Missense_Mutation_p.A78T|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	325	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CACAAACGGCGCACATTGGTA	0.413													0	0	0	0.01441	0	149	279										A	28712233	G	A	28712233	3	1	47	1	0	0	0	0	1	0	0	0	3798	1087	38	2	979	2	CPD	17	28712233	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	9231496	28712233	52482977	225	13706										
COPZ2	51226	broad.mit.edu	37	chr17	46111232	46111232	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagagggggacacttactctCagtccggctggtcttgttga	13	9	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:46111232C>G	uc002imy.2	-	7	278	c.265G>C	c.(265-267)GAG>CAG	p.E89Q		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CACTTACTCTCAGTCCGGCTG	0.483													0	0	0	0.001168	0	6	24										G	46111232	C	G	46111232	3	3	47	1	0	0	0	0	1	0	0	0	3742	835	29	1	395	1	COPZ2	17	46111232	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	17398999	46111232	35083978	226	13707										
CACNA1G	8913	broad.mit.edu	37	chr17	48681582	48681582	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atgtcctcactgaaacccatCggcaacattgtagtcatctg	7	12	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:48681582C>A	uc002irk.1	+	22	4608	c.4236C>A	c.(4234-4236)ATC>ATA	p.I1412I	CACNA1G_uc002iri.1_Silent_p.I1412I|CACNA1G_uc002irj.1_Silent_p.I1389I|CACNA1G_uc002irl.1_Silent_p.I1389I|CACNA1G_uc002irm.1_Silent_p.I1389I|CACNA1G_uc002irn.1_Silent_p.I1389I|CACNA1G_uc002iro.1_Silent_p.I1389I|CACNA1G_uc002irp.1_Silent_p.I1412I|CACNA1G_uc002irq.1_Silent_p.I1389I|CACNA1G_uc002irr.1_Silent_p.I1412I|CACNA1G_uc002irs.1_Silent_p.I1412I|CACNA1G_uc002irt.1_Silent_p.I1412I|CACNA1G_uc002irv.1_Silent_p.I1412I|CACNA1G_uc002irw.1_Silent_p.I1389I|CACNA1G_uc002iru.1_Silent_p.I1389I|CACNA1G_uc002irx.1_Silent_p.I1325I|CACNA1G_uc002iry.1_Silent_p.I1325I|CACNA1G_uc002irz.1_Silent_p.I1325I|CACNA1G_uc002isa.1_Silent_p.I1325I|CACNA1G_uc002isb.1_Silent_p.I1325I|CACNA1G_uc002isc.1_Silent_p.I1325I|CACNA1G_uc002isd.1_Silent_p.I1325I|CACNA1G_uc002ise.1_Silent_p.I1325I|CACNA1G_uc002isf.1_Silent_p.I1325I|CACNA1G_uc002isg.1_Silent_p.I1325I|CACNA1G_uc002ish.1_Silent_p.I1325I|CACNA1G_uc002isi.1_Silent_p.I1302I|CACNA1G_uc002isj.2_Silent_p.I136I	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1412	Helical; Name=S5 of repeat III; (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TGAAACCCATCGGCAACATTG	0.597													1	0	1.16021e-09	0.007291	1.21617e-09	31	110										A	48681582	C	A	48681582	2	1	47	1	0	0	0	0	0	0	0	1	2544	874	31	3		3	CACNA1G	17	48681582	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2570350	48681582	32513628	227	13708										
CACNA1G	8913	broad.mit.edu	37	chr17	48681612	48681612	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtagtcatctgctgtgccttCttcatcattttcggcatctt	7	11	6	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:48681612C>T	uc002irk.1	+	22	4638	c.4266C>T	c.(4264-4266)TTC>TTT	p.F1422F	CACNA1G_uc002iri.1_Silent_p.F1422F|CACNA1G_uc002irj.1_Silent_p.F1399F|CACNA1G_uc002irl.1_Silent_p.F1399F|CACNA1G_uc002irm.1_Silent_p.F1399F|CACNA1G_uc002irn.1_Silent_p.F1399F|CACNA1G_uc002iro.1_Silent_p.F1399F|CACNA1G_uc002irp.1_Silent_p.F1422F|CACNA1G_uc002irq.1_Silent_p.F1399F|CACNA1G_uc002irr.1_Silent_p.F1422F|CACNA1G_uc002irs.1_Silent_p.F1422F|CACNA1G_uc002irt.1_Silent_p.F1422F|CACNA1G_uc002irv.1_Silent_p.F1422F|CACNA1G_uc002irw.1_Silent_p.F1399F|CACNA1G_uc002iru.1_Silent_p.F1399F|CACNA1G_uc002irx.1_Silent_p.F1335F|CACNA1G_uc002iry.1_Silent_p.F1335F|CACNA1G_uc002irz.1_Silent_p.F1335F|CACNA1G_uc002isa.1_Silent_p.F1335F|CACNA1G_uc002isb.1_Silent_p.F1335F|CACNA1G_uc002isc.1_Silent_p.F1335F|CACNA1G_uc002isd.1_Silent_p.F1335F|CACNA1G_uc002ise.1_Silent_p.F1335F|CACNA1G_uc002isf.1_Silent_p.F1335F|CACNA1G_uc002isg.1_Silent_p.F1335F|CACNA1G_uc002ish.1_Silent_p.F1335F|CACNA1G_uc002isi.1_Silent_p.F1312F|CACNA1G_uc002isj.2_Silent_p.F146F	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1422	Helical; Name=S5 of repeat III; (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCTGTGCCTTCTTCATCATTT	0.607													0	0	0	0.019004	0	32	129										T	48681612	C	T	48681612	2	4	47	1	0	0	0	0	0	0	0	1	2544	912	32	1		1	CACNA1G	17	48681612	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	30	48681612	32513598	228	13709										
ABCC3	8714	broad.mit.edu	37	chr17	48761367	48761367	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccatgaccctttgcctgttcCgcatcctggaggcggcaaag	11	14	0	1	rs141762939		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:48761367C>A	uc002isl.2	+	28	4092	c.4012C>A	c.(4012-4014)CGC>AGC	p.R1338S	ABCC3_uc002isn.2_Missense_Mutation_p.R92S	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1338	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTGCCTGTTCCGCATCCTGGA	0.622													1	0	9.84934e-19	0.010771	1.07029e-18	42	18										A	48761367	C	A	48761367	3	1	47	1	0	0	0	0	1	0	0	0	54	652	23	4	4206	4	ABCC3	17	48761367	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	79755	48761367	32433843	229	13710										
GNA13	10672	broad.mit.edu	37	chr17	63052540	63052540	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gaaggtggacttgccgctctCgcccgcgcccagcagcagga	14	15	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:63052540C>T	uc002jfc.2	-	1	381	c.172G>A	c.(172-174)GAG>AAG	p.E58K	GNA13_uc010wqh.1_5'Flank	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	58	GTP (By similarity).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						TTGCCGCTCTCGCCCGCGCCC	0.617													0	0	0	0.013726	0	34	124										T	63052540	C	T	63052540	3	4	47	1	0	0	0	0	1	0	0	0	6501	893	31	1	977	1	GNA13	17	63052540	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	14291173	63052540	18142670	230	13711										
CCDC46	201134	broad.mit.edu	37	chr17	64171210	64171210	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagtgttatcttctccagaaGagagtttccatgattcattt	7	7	3	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr17:64171210G>C	uc002jfl.2	-	4	641	c.422C>G	c.(421-423)TCT>TGT	p.S141C	CCDC46_uc002jfm.2_Missense_Mutation_p.S141C|CCDC46_uc010dep.2_Missense_Mutation_p.S141C	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	141						centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TTCTCCAGAAGAGAGTTTCCA	0.423													0	0	0	0.012213	0	33	187										C	64171210	G	C	64171210	3	2	47	1	0	0	0	0	1	0	0	0	2817	942	33	1	2707	1	CCDC46	17	64171210	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1118670	64171210	17024000	231	13712										
DSC1	1823	broad.mit.edu	37	chr18	28736055	28736055	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acgagttctccatcaatgaaGctggaataggagcccatcgt	10	10	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:28736055G>T	uc002kwn.2	-	4	684	c.422C>A	c.(421-423)GCT>GAT	p.A141D	DSC1_uc002kwm.2_Missense_Mutation_p.A141D	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	141	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CATCAATGAAGCTGGAATAGG	0.403													1	0	3.5997e-14	0.014323	3.83497e-14	23	71										T	28736055	G	T	28736055	3	4	47	1	0	0	0	0	1	0	0	0	4765	971	34	4	2354	4	DSC1	18	28736055	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		28736055	49341193	232	13713										
B4GALT6	9331	broad.mit.edu	37	chr18	29206280	29206280	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gacttcacctctatggtgatGaggaattgacttgtattttc	9	7	2	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:29206280G>C	uc002kwz.3	-	8	1264	c.967C>G	c.(967-969)CAT>GAT	p.H323D	B4GALT6_uc010dma.2_Missense_Mutation_p.H284D|B4GALT6_uc010dmb.2_Missense_Mutation_p.H284D|B4GALT6_uc002kwy.3_RNA	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	323	Lumenal (Potential).	Manganese (By similarity).			post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			CTATGGTGATGAGGAATTGAC	0.358													0	0	0	0.011902	0	45	15										C	29206280	G	C	29206280	3	2	47	1	0	0	0	0	1	0	0	0	1275	1290	45	1	189	1	B4GALT6	18	29206280	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	470225	29206280	48870968	233	13714										
DYM	54808	broad.mit.edu	37	chr18	46904947	46904947	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	caatacttactgtaattgccAggagatttttcttcataagt	6	7	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:46904947A>G	uc002ldi.1	-	5	776	c.411T>C	c.(409-411)CCT>CCC	p.P137P	DYM_uc010xdf.1_Intron	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	137						Golgi apparatus					0						TGTAATTGCCAGGAGATTTTT	0.289													0	0	0	0.014323	0	24	41										G	46904947	A	G	46904947	2	3	47	1	0	0	0	0	0	0	0	1	4840	175	7	5		5	DYM	18	46904947	Silent	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	17698667	46904947	31172301	234	13715										
ZNF236	7776	broad.mit.edu	37	chr18	74606980	74606980	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccttcacaggctccatccgcGaggagaacggcgtgcgctgg	14	14	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:74606980G>A	uc002lmi.2	+	10	1621	c.1423G>A	c.(1423-1425)GAG>AAG	p.E475K	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	475					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CTCCATCCGCGAGGAGAACGG	0.657													0	0	0	0.011902	0	36	68										A	74606980	G	A	74606980	3	1	47	1	0	0	0	0	1	0	0	0	17786	1059	37	1	1461	1	ZNF236	18	74606980	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	27702033	74606980	3470268	235	13716										
ZNF236	7776	broad.mit.edu	37	chr18	74617282	74617282	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttacggcgacacatgggtatCcacaacgaccttcgtcccta	8	14	0	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr18:74617282C>G	uc002lmi.2	+	13	2400	c.2202C>G	c.(2200-2202)ATC>ATG	p.I734M	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	734	C2H2-type 16.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		ACATGGGTATCCACAACGACC	0.433													0	0	0	0.006122	0	19	22										G	74617282	C	G	74617282	3	3	47	1	0	0	0	0	1	0	0	0	17786	845	30	1	2252	1	ZNF236	18	74617282	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	10302	74617282	3459966	236	13717										
S1PR4	8698	broad.mit.edu	37	chr19	3179545	3179545	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ggcccgccgcctgctgaagaCggtgctgatgatcctgctgg	15	13	0	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:3179545C>T	uc002lxg.2	+	1	780	c.755C>T	c.(754-756)ACG>ATG	p.T252M		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	252	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CTGCTGAAGACGGTGCTGATG	0.687													0	0	0	0.008871	0	15	34										T	3179545	C	T	3179545	3	4	47	1	0	0	0	0	1	0	0	0	13796	536	19	2	757	2	S1PR4	19	3179545	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		3179545	55949438	237	13718										
HDGFRP2	84717	broad.mit.edu	37	chr19	4475339	4475339	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccccatctttttctttggcaCacacgaaacgtaagtgtccc	6	14	2	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:4475339C>T	uc002mao.2	+	2	233	c.140C>T	c.(139-141)ACA>ATA	p.T47I	HDGFRP2_uc002map.2_Missense_Mutation_p.T47I|HDGFRP2_uc010dtz.1_5'Flank	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	47	PWWP.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						TTCTTTGGCACACACGAAACG	0.602													0	0	0	0.006122	0	18	29										T	4475339	C	T	4475339	3	4	47	1	0	0	0	0	1	0	0	0	7020	478	17	2	146	2	HDGFRP2	19	4475339	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1295794	4475339	54653644	238	13719										
FBN3	84467	broad.mit.edu	37	chr19	8193911	8193911	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cgtgagcccgggacccagtaCctttgcagatctccgtgtcc	11	15	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:8193911C>T	uc002mjf.2	-	17	2317	c.2296_splice	c.e17+1	p.D766_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGACCCAGTACCTTTGCAGAT	0.592													0	0	0	0.008871	0	17	39										T	8193911	C	T	8193911	5	4	47	1	0	0	0	0	0	0	1	0	5704	521	18	2	6320	2	FBN3	19	8193911	Splice_Site	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	3718572	8193911	50935072	239	13720										
ZNF700	90592	broad.mit.edu	37	chr19	12059541	12059541	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gggaaagccttccattctttCagtttatatcttatccatga	6	9	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:12059541C>T	uc002msu.2	+	4	828	c.702C>T	c.(700-702)TTC>TTT	p.F234F	ZNF700_uc010xme.1_Silent_p.F252F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	234	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCATTCTTTCAGTTTATATC	0.348													0	0	0	0.012319	0	22	81										T	12059541	C	T	12059541	2	4	47	1	0	0	0	0	0	0	0	1	18101	825	29	1		1	ZNF700	19	12059541	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	3865630	12059541	47069442	240	13721										
ZSWIM4	65249	broad.mit.edu	37	chr19	13936478	13936478	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gacagccaccccggtcagcgCcccaccagacaccacgctgc	9	21	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:13936478C>T	uc002mxh.1	+	11	2168	c.1979C>T	c.(1978-1980)GCC>GTC	p.A660V	ZSWIM4_uc010xng.1_Missense_Mutation_p.A583V	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	660							zinc ion binding	p.A660A(1)		central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CCGGTCAGCGCCCCACCAGAC	0.677													0	0	0	0.013726	0	30	24										T	13936478	C	T	13936478	3	4	47	1	0	0	0	0	1	0	0	0	18240	739	26	2	2021	2	ZSWIM4	19	13936478	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1876937	13936478	45192505	241	13722										
ZNF626	199777	broad.mit.edu	37	chr19	20807939	20807939	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttctctccagtatgatttctCttatgtgtagtaagagtgga	9	6	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:20807939C>G	uc002npb.1	-	4	894	c.744G>C	c.(742-744)AAG>AAC	p.K248N	ZNF626_uc002npc.1_Missense_Mutation_p.K172N	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	248	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TATGATTTCTCTTATGTGTAG	0.383													0	0	0	0.013114	0	45	104										G	20807939	C	G	20807939	3	3	47	1	0	0	0	0	1	0	0	0	18047	912	32	1	846	1	ZNF626	19	20807939	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	6871461	20807939	38321044	242	13723										
APLP1	333	broad.mit.edu	37	chr19	36369852	36369852	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cggagattcagagggatgagCtggtaagaggaggaacagcc	17	6	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:36369852C>T	uc002oce.2	+	15	1846	c.1708C>T	c.(1708-1710)CTG>TTG	p.L570L	APLP1_uc010xsz.1_Silent_p.L531L|APLP1_uc002ocf.2_Silent_p.L571L|APLP1_uc002ocg.2_Silent_p.L474L|APLP1_uc010xta.1_Silent_p.L564L	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	570	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGGGATGAGCTGGTAAGAGG	0.582													0	0	0	0.01441	0	51	23										T	36369852	C	T	36369852	2	4	47	1	0	0	0	0	0	0	0	1	778	796	28	2		2	APLP1	19	36369852	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	15561913	36369852	22759131	243	13724										
MEGF8	1954	broad.mit.edu	37	chr19	42830399	42830399	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagtgcaggaggcggcgatgGccctgggcaaggttctggcc	18	11	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:42830399G>A	uc002otl.3	+	1	639	c.4G>A	c.(4-6)GCC>ACC	p.A2T		NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2						integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GGCGGCGATGGCCCTGGGCAA	0.672											OREG0025502	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	12	12										A	42830399	G	A	42830399	3	1	47	1	0	0	0	0	1	0	0	0	9463	1203	42	2	6	2	MEGF8	19	42830399	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	6460547	42830399	16298584	244	13725										
PSG7	5676	broad.mit.edu	37	chr19	43439844	43439844	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagtagaagaacatccttccCctcggaaacttttggtggct	9	10	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:43439844C>G	uc002ovl.3	-	2	244	c.142G>C	c.(142-144)GGG>CGG	p.G48R	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	48	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				ACATCCTTCCCCTCGGAAACT	0.488													0	0	0	0.01441	0	41	294										G	43439844	C	G	43439844	3	3	47	1	0	0	0	0	1	0	0	0	12660	623	22	4	1137	4	PSG7	19	43439844	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	609445	43439844	15689139	245	13726										
IRGQ	126298	broad.mit.edu	37	chr19	44099434	44099434	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gctgcgatcagcgcggacttCcccaagcccggaggccccag	13	17	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:44099434C>T	uc002oww.2	-	1	175	c.57G>A	c.(55-57)GGG>GGA	p.G19G	IRGQ_uc010eiv.2_Silent_p.G19G|ZNF576_uc002owy.2_5'Flank|ZNF576_uc002owz.2_5'Flank|SRRM5_uc002oxb.2_5'Flank	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	19							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				GCGCGGACTTCCCCAAGCCCG	0.682													0	0	0	0.020292	0	14	48										T	44099434	C	T	44099434	2	4	47	1	0	0	0	0	0	0	0	1	7839	842	30	1		1	IRGQ	19	44099434	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	659590	44099434	15029549	246	13727										
PVRL2	5819	broad.mit.edu	37	chr19	45375390	45375390	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gaaccagccctgatacctgtGaccctctctgtacgctgtga	9	14	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:45375390G>A	uc002ozw.1	+	3	1149	c.759G>A	c.(757-759)GTG>GTA	p.V253V	PVRL2_uc002ozv.2_Silent_p.V253V	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	253	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TGATACCTGTGACCCTCTCTG	0.567													0	0	0	0.00499	0	17	93										A	45375390	G	A	45375390	2	1	47	1	0	0	0	0	0	0	0	1	12840	1277	45	1		1	PVRL2	19	45375390	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1275956	45375390	13753593	247	13728										
CCDC114	93233	broad.mit.edu	37	chr19	48800570	48800570	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgaggccgccaaaagtgacgTggccaagagagccacggtct	14	11	1	3			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:48800570T>C	uc002pir.2	-	14	2359	c.1676A>G	c.(1675-1677)CAC>CGC	p.H559R	CCDC114_uc002piq.2_Missense_Mutation_p.H368R|CCDC114_uc002pio.2_3'UTR	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	559										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		AAAAGTGACGTGGCCAAGAGA	0.637													0	0	0	0.008871	0	18	21										C	48800570	T	C	48800570	3	2	47	1	0	0	0	0	1	0	0	0	2751	1696	59	5	340	5	CCDC114	19	48800570	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	3425180	48800570	10328413	248	13729										
C19orf41	126123	broad.mit.edu	37	chr19	50666011	50666011	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctacctttcagagagttacCcattaagtgctgcgtttggt	9	10	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:50666011C>A	uc002prp.1	-	2	379	c.292G>T	c.(292-294)GGT>TGT	p.G98C		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	98	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		AGAGAGTTACCCATTAAGTGC	0.537													1	0	1.06647e-15	0.017118	1.14365e-15	31	67										A	50666011	C	A	50666011	3	1	47	1	0	0	0	0	1	0	0	0	1924	623	22	4	397	4	C19orf41	19	50666011	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1865441	50666011	8462972	249	13730										
LILRB2	10288	broad.mit.edu	37	chr19	54782754	54782754	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcatctgtactggcccccgtAggagcggctcacagggccca	13	15	2	0	rs143661416	byFrequency	TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:54782754A>G	uc002qfb.2	-	6	1134	c.868T>C	c.(868-870)TAC>CAC	p.Y290H	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.Y290H|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.Y290H|LILRB2_uc010yet.1_Missense_Mutation_p.Y174H|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	290	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGCCCCCGTAGGAGCGGCTC	0.667													0	0	0	0.00499	0	13	52										G	54782754	A	G	54782754	3	3	47	1	0	0	0	0	1	0	0	0	8791	420	15	5	964	5	LILRB2	19	54782754	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	4116743	54782754	4346229	250	13731										
KIR2DL3	3804	broad.mit.edu	37	chr19	55263182	55263182	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cctcctcttctttctccttcAtcgctggtgctgcaacaaaa	5	15	4	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:55263182A>T	uc002qgv.2	+	6	815	c.797A>T	c.(796-798)CAT>CTT	p.H266L	KIR2DL3_uc002qgx.2_Missense_Mutation_p.H266L|KIR2DL3_uc002qgy.2_Missense_Mutation_p.H168L|KIR2DL3_uc010erw.1_Missense_Mutation_p.H266L|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron	NM_015868	NP_056952	P43628	KI2L3_HUMAN	killer cell immunoglobulin-like receptor, two	266	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	antigen binding|protein binding|receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(193;0.0192)		tttctccttcATCGCTGGTGC	0.438													0	0	0	0.01441	0	62	115										T	55263182	A	T	55263182	3	4	47	1	0	0	0	0	1	0	0	0	8317	217	8	5	819	5	KIR2DL3	19	55263182	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	480428	55263182	3865801	251	13732										
SYT5	6861	broad.mit.edu	37	chr19	55689707	55689707	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gatgaggaggcctgagaccaGcacgatggtggccagggccc	17	11	0	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr19:55689707G>T	uc002qjm.1	-	2	1169	c.109C>A	c.(109-111)CTG>ATG	p.L37M	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Missense_Mutation_p.L37M|SYT5_uc002qjo.1_Missense_Mutation_p.L37M	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	37	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCTGAGACCAGCACGATGGTG	0.617													1	0	2.74318e-10	0.006214	2.88476e-10	9	5										T	55689707	G	T	55689707	3	4	47	1	0	0	0	0	1	0	0	0	15474	962	34	4	1079	4	SYT5	19	55689707	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	426525	55689707	3439276	252	13733										
DEFB125	245938	broad.mit.edu	37	chr20	76884	76884	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gtatctatgttgaatgatctGataacatttgacacaactaa	6	6	2	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:76884G>C	uc002wcw.2	+	2	297	c.297G>C	c.(295-297)CTG>CTC	p.L99L		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	99					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			TGAATGATCTGATAACATTTG	0.423													0	0	0	0.01441	0	173	127										C	76884	G	C	76884	2	2	47	1	0	0	0	0	0	0	0	1	4411	1277	45	1		1	DEFB125	20	76884	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08		76884	62948636	253	13734										
MCM8	84515	broad.mit.edu	37	chr20	5935320	5935320	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aaaatttttcacaaggcataTtgatttgtatgacaaggtaa	7	4	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:5935320T>G	uc002wmi.2	+	4	697	c.320T>G	c.(319-321)ATT>AGT	p.I107S	MCM8_uc002wmj.2_Missense_Mutation_p.I107S|MCM8_uc002wmk.2_Missense_Mutation_p.I107S|MCM8_uc002wml.2_Missense_Mutation_p.I107S|MCM8_uc010gbp.2_Missense_Mutation_p.I107S	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	107					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						ACAAGGCATATTGATTTGTAT	0.318													0	0	0	0.00499	0	16	58										G	5935320	T	G	5935320	3	3	47	1	0	0	0	0	1	0	0	0	9393	1493	52	5	330	5	MCM8	20	5935320	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	5858436	5935320	57090200	254	13735										
PCSK2	5126	broad.mit.edu	37	chr20	17446013	17446013	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atgcagcatctgactgtgctCacctccaaacggaaccagct	8	14	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:17446013C>G	uc002wpm.2	+	11	1565	c.1245C>G	c.(1243-1245)CTC>CTG	p.L415L	PCSK2_uc002wpl.2_Silent_p.L396L|PCSK2_uc010zrm.1_Silent_p.L380L|PCSK2_uc002wpn.2_Silent_p.L69L	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	415	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGACTGTGCTCACCTCCAAAC	0.582													0	0	0	0.014758	0	3	24										G	17446013	C	G	17446013	2	3	47	1	0	0	0	0	0	0	0	1	11601	813	29	1		1	PCSK2	20	17446013	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	11510693	17446013	45579507	255	13736										
SSTR4	6754	broad.mit.edu	37	chr20	23017255	23017255	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aaccagaacccggccgcaagCgcatccccctcaccaggacc	8	20	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:23017255C>T	uc002wsr.2	+	1	1199	c.1135C>T	c.(1135-1137)CGC>TGC	p.R379C		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	379	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGCCGCAAGCGCATCCCCCT	0.657													0	0	0	0.008871	0	17	60										T	23017255	C	T	23017255	3	4	47	1	0	0	0	0	1	0	0	0	15199	768	27	2	1137	2	SSTR4	20	23017255	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	5571242	23017255	40008265	256	13737										
RBM39	9584	broad.mit.edu	37	chr20	34295071	34295071	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttaaacatgttagagagttgGaaacattgtgttgcaagtgg	12	3	0	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:34295071G>C	uc002xeb.2	-	14	1622	c.1278C>G	c.(1276-1278)TTC>TTG	p.F426L	RBM39_uc002xdz.2_Missense_Mutation_p.F402L|RBM39_uc002xea.2_Missense_Mutation_p.F269L|RBM39_uc010gfn.2_Missense_Mutation_p.F269L|RBM39_uc010zvm.1_Missense_Mutation_p.F398L|RBM39_uc002xeg.2_Missense_Mutation_p.F404L|RBM39_uc002xec.2_Missense_Mutation_p.F420L|RBM39_uc002xed.2_Missense_Mutation_p.F144L|RBM39_uc002xee.2_Missense_Mutation_p.F269L|RBM39_uc002xef.2_Missense_Mutation_p.F263L|RBM39_uc010zvn.1_Missense_Mutation_p.F269L	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	426	Interaction with NCOA6 (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TAGAGAGTTGGAAACATTGTG	0.333													0	0	0	0.00499	0	14	67										C	34295071	G	C	34295071	3	2	47	1	0	0	0	0	1	0	0	0	13133	1165	41	1	330	1	RBM39	20	34295071	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	11277816	34295071	28730449	257	13738										
AURKA	6790	broad.mit.edu	37	chr20	54945601	54945601	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tcaaaaggaggcttcccaacTaaaaattcatagcaaagaac	6	9	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:54945601T>G	uc002xxd.1	-	10	1535	c.969A>C	c.(967-969)TTA>TTC	p.L323F	AURKA_uc002xxe.1_Missense_Mutation_p.L323F|AURKA_uc002xxf.1_Missense_Mutation_p.L323F|AURKA_uc002xxg.1_Missense_Mutation_p.L323F|AURKA_uc002xxh.1_Missense_Mutation_p.L323F|AURKA_uc002xxi.1_Missense_Mutation_p.L323F|AURKA_uc002xxj.1_Missense_Mutation_p.L323F|AURKA_uc002xxk.1_Missense_Mutation_p.L323F|AURKA_uc010zzd.1_RNA	NM_198433	NP_940835	O14965	AURKA_HUMAN	serine/threonine protein kinase 6	323	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(1)|large_intestine(1)|skin(1)	8			Colorectal(105;0.202)			GCTTCCCAACTAAAAATTCAT	0.478													0	0	0	0.013726	0	30	88										G	54945601	T	G	54945601	3	3	47	1	0	0	0	0	1	0	0	0	1221	1519	53	5	250	5	AURKA	20	54945601	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	20650530	54945601	8079919	258	13739										
ZGPAT	84619	broad.mit.edu	37	chr20	62340259	62340259	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	accgttcctaaagcagaggcGgggccagaatctgcggcagg	15	11	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr20:62340259G>A	uc002ygk.2	+	2	505	c.327G>A	c.(325-327)GCG>GCA	p.A109A	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Silent_p.A109A|ZGPAT_uc002ygj.2_Silent_p.A109A|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Silent_p.A109A|ZGPAT_uc002ygm.2_Silent_p.A109A|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	109					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					AAGCAGAGGCGGGGCCAGAAT	0.547													0	0	0	0.014323	0	19	37										A	62340259	G	A	62340259	2	1	47	1	0	0	0	0	0	0	0	1	17671	1103	39	2		2	ZGPAT	20	62340259	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	7394658	62340259	685261	259	13740										
NCAM2	4685	broad.mit.edu	37	chr21	22656638	22656638	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	accatctacaatgcaaatatAgaagatgcagggatatatcg	8	7	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:22656638A>G	uc002yld.1	+	3	504	c.255A>G	c.(253-255)ATA>ATG	p.I85M	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.I110M	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	85	Ig-like C2-type 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ATGCAAATATAGAAGATGCAG	0.368													0	0	0	0.01441	0	49	87										G	22656638	A	G	22656638	3	3	47	1	0	0	0	0	1	0	0	0	10203	410	15	5	265	5	NCAM2	21	22656638	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08		22656638	25473257	260	13741										
KRTAP6-3	337968	broad.mit.edu	37	chr21	31964950	31964950	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgtggctatggaggcctgggCtgtggctatggctccttctg	16	9	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:31964950C>T	uc002yom.2	+	1	192	c.186C>T	c.(184-186)GGC>GGT	p.G62G		NM_181605	NP_853636			keratin associated protein 6-3												0						gaggcctgggctgtggctatg	0.085													0	0	0	0.00499	0	14	27										T	31964950	C	T	31964950	2	4	47	1	0	0	0	0	0	0	0	1	8571	784	28	2		2	KRTAP6-3	21	31964950	Silent	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	9308312	31964950	16164945	261	13742										
SFRS15	57466	broad.mit.edu	37	chr21	33076179	33076179	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	atcagttccaaactgatgacGagactgtcgcacaattgagt	9	9	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:33076179G>A	uc002ypd.2	-	4	646	c.220C>T	c.(220-222)CGT>TGT	p.R74C	SFRS15_uc002ype.2_Missense_Mutation_p.R74C|SFRS15_uc010glu.2_Missense_Mutation_p.R59C|SFRS15_uc002ypf.1_5'Flank|SFRS15_uc002ypg.2_Missense_Mutation_p.R74C	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	74	CID.					nucleus	nucleotide binding|RNA binding				0						AACTGATGACGAGACTGTCGC	0.353													0	0	0	0.01441	0	63	144										A	33076179	G	A	33076179	3	1	47	1	0	0	0	0	1	0	0	0	14171	1058	37	1	3291	1	SFRS15	21	33076179	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1111229	33076179	15053716	262	13743										
BRWD1	54014	broad.mit.edu	37	chr21	40636481	40636481	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	acttggttggatgaggatttCcatctacatctaccaagaat	8	8	2	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636481C>A	uc002yxk.1	-	17	1929	c.1790G>T	c.(1789-1791)GGA>GTA	p.G597V	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.G597V|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Missense_Mutation_p.G50V|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.G317V	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	597					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATGAGGATTTCCATCTACATC	0.413													1	0	7.41877e-09	0.012319	7.70229e-09	11	170										A	40636481	C	A	40636481	3	1	47	1	0	0	0	0	1	0	0	0	1525	855	30	3	5515	3	BRWD1	21	40636481	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	7560302	40636481	7493414	263	13744			2	50		5	4	393	N	C	7.27411e-09
BRWD1	54014	broad.mit.edu	37	chr21	40636563	40636563	+	Missense_Mutation	SNP	C	C	T													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	taagacataattattagaatCtctaataagtggtcgatagt							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636563C>T	uc002yxk.1	-	17	1847	c.1708G>A	c.(1708-1710)GAT>AAT	p.D570N	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.D570N|BRWD1_uc010goe.1_Intron|BRWD1_uc010gof.1_Missense_Mutation_p.D23N|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.D290N	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTATTAGAATCTCTAATAAGT	0.373													0	0	0	0.010729	0	8	83										T	40636563	C	T	40636563	3	4	47	1	0	0	0	0	1	0	0	0	1525	913	32	1	5597	1	BRWD1	21	40636563	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	82	40636563	7493332	264	13745	68	2	2	50		5	4	393	N	C	7.27411e-09
BRWD1	54014	broad.mit.edu	37	chr21	40636565	40636565	+	Missense_Mutation	SNP	C	C	T													0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agacataattattagaatctCtaataagtggtcgatagtca							TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636565C>T	uc002yxk.1	-	17	1845	c.1706G>A	c.(1705-1707)AGA>AAA	p.R569K	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.R569K|BRWD1_uc010goe.1_Intron|BRWD1_uc010gof.1_Missense_Mutation_p.R22K|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.R289K	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	569					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATTAGAATCTCTAATAAGTGG	0.378													0	0	0	0.008291	0	8	83										T	40636565	C	T	40636565	3	4	47	1	0	0	0	0	1	0	0	0	1525	913	32	1	5599	1	BRWD1	21	40636565	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2	40636565	7493330	265	13746	68	2	2	50		5	4	393	N	C	7.27411e-09
BRWD1	54014	broad.mit.edu	37	chr21	40636822	40636822	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	agtattaaaaatgaccttttCatatggtttgctgcatccaa	6	7	1	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636822C>T	uc002yxk.1	-	16	1793	c.1654G>A	c.(1654-1656)GAA>AAA	p.E552K	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.E552K|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Intron|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.E272K	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	552	WD 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATGACCTTTTCATATGGTTTG	0.358													0	0	0	0.010729	0	10	118										T	40636822	C	T	40636822	3	4	47	1	0	0	0	0	1	0	0	0	1525	835	29	1	5655	1	BRWD1	21	40636822	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	257	40636822	7493073	266	13747			2	50		5	4	393	N	C	7.27411e-09
BRWD1	54014	broad.mit.edu	37	chr21	40636873	40636873	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cagaaggtgcccatgagaatCtgtacaggcaaaatgctgtc	11	9	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:40636873C>G	uc002yxk.1	-	16	1742	c.1603G>C	c.(1603-1605)GAT>CAT	p.D535H	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.D535H|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Intron|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.D255H	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	535	WD 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CCATGAGAATCTGTACAGGCA	0.373											OREG0003860	type=REGULATORY REGION|Gene=AK125906|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.016723	0	10	144										G	40636873	C	G	40636873	3	3	47	1	0	0	0	0	1	0	0	0	1525	913	32	1	5706	1	BRWD1	21	40636873	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	51	40636873	7493022	267	13748			2	50		5	4	393	N	C	7.27411e-09
SLC19A1	6573	broad.mit.edu	37	chr21	46945798	46945798	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	aagtgatgatggtcttgacgAtggtggcaaagaacgtgttg	15	4	1	4			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr21:46945798A>G	uc002zhl.1	-	5	1345	c.1226T>C	c.(1225-1227)ATC>ACC	p.I409T	SLC19A1_uc010gpy.1_Missense_Mutation_p.I409T|SLC19A1_uc011aft.1_Missense_Mutation_p.I369T|SLC19A1_uc002zhm.1_Missense_Mutation_p.I409T|SLC19A1_uc010gpz.1_Missense_Mutation_p.I288T	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	409	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GGTCTTGACGATGGTGGCAAA	0.577													0	0	0	0.00632	0	25	82										G	46945798	A	G	46945798	3	3	47	1	0	0	0	0	1	0	0	0	14428	333	12	5	557	5	SLC19A1	21	46945798	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	6308925	46945798	1184097	268	13749										
P2RX6	9127	broad.mit.edu	37	chr22	21377871	21377871	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctctggctgctggcctcactActccttccagctgcaggaga	10	15	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:21377871A>G	uc010gsu.1	+	8	854	c.854A>G	c.(853-855)TAC>TGC	p.Y285C	P2RX6_uc002ztz.2_Missense_Mutation_p.Y259C|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	285	Extracellular (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TGGCCTCACTACTCCTTCCAG	0.607													0	0	0	0.004482	0	8	21										G	21377871	A	G	21377871	3	3	47	1	0	0	0	0	1	0	0	0	11344	391	14	5	884	5	P2RX6	22	21377871	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08		21377871	29926695	269	13750										
RASL10A	10633	broad.mit.edu	37	chr22	29709953	29709953	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gcgtccgtgtcctgcaagctCcagtccttagcgtctggcca	11	15	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:29709953C>G	uc003aff.2	-	2	756	c.243G>C	c.(241-243)TGG>TGC	p.W81C	RASL10A_uc003afg.2_Missense_Mutation_p.W81C	NM_006477	NP_006468	Q92737	RSLAA_HUMAN	RAS-related on chromosome 22 isoform a	81	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity				0						CCTGCAAGCTCCAGTCCTTAG	0.637													0	0	0	0.00632	0	22	41										G	29709953	C	G	29709953	3	3	47	1	0	0	0	0	1	0	0	0	13079	856	30	1	380	1	RASL10A	22	29709953	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	8332082	29709953	21594613	270	13751										
PKDREJ	10343	broad.mit.edu	37	chr22	46655856	46655856	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ataccagctggtcttctcacCaagaatgcaataaccctctc	5	14	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:46655856C>T	uc003bhh.2	-	1	3364	c.3364G>A	c.(3364-3366)GGT>AGT	p.G1122S		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1122	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GTCTTCTCACCAAGAATGCAA	0.498													0	0	0	0.006999	0	39	183										T	46655856	C	T	46655856	3	4	47	1	0	0	0	0	1	0	0	0	11970	594	21	2	3401	2	PKDREJ	22	46655856	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	16945903	46655856	4648710	271	13752										
ZBED4	9889	broad.mit.edu	37	chr22	50280171	50280171	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	gagcacgcagatgtccacccTcagccaggtcatccccatgg	10	16	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chr22:50280171T>A	uc003bix.2	+	2	3331	c.2861T>A	c.(2860-2862)CTC>CAC	p.L954H		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	954						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		ATGTCCACCCTCAGCCAGGTC	0.602													0	0	0	0.010729	0	9	41										A	50280171	T	A	50280171	3	1	47	1	0	0	0	0	1	0	0	0	17517	1551	54	5	2863	5	ZBED4	22	50280171	Missense_Mutation	SNP	T	TCGA-DK-A1AD-01A-11D-A13W-08	3624315	50280171	1024395	272	13753										
DMD	1756	broad.mit.edu	37	chrX	32662325	32662325	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	attcatctgctcttgtacttCagtttcttcatcttctgata	4	10	8	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:32662325C>T	uc004dda.1	-	11	1499	c.1255G>A	c.(1255-1257)GAA>AAA	p.E419K	DMD_uc004dcz.2_Missense_Mutation_p.E296K|DMD_uc004dcy.1_Missense_Mutation_p.E415K|DMD_uc004ddb.1_Missense_Mutation_p.E411K|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.E411K|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|MIR548F5_hsa-mir-548f-5|MI0006378_5'Flank	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	419	Spectrin 1.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTGTACTTCAGTTTCTTCA	0.388													0	0	0	0.01441	0	134	24										T	32662325	C	T	32662325	3	4	47	1	0	0	0	0	1	0	0	0	4580	835	29	1	10321	1	DMD	23	32662325	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08		32662325	122608235	273	13754										
FAM47A	158724	broad.mit.edu	37	chrX	34150089	34150089	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tggagagagcttggaaaataGggccgctttcttgagcagct	14	7	1	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:34150089G>A	uc004ddg.2	-	1	340	c.307C>T	c.(307-309)CTA>TTA	p.L103L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	103										ovary(4)|central_nervous_system(1)	5						TTGGAAAATAGGGCCGCTTTC	0.542													0	0	0	0.01441	0	94	14										A	34150089	G	A	34150089	2	1	47	1	0	0	0	0	0	0	0	1	5569	991	35	2		2	FAM47A	23	34150089	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	1487764	34150089	121120471	274	13755										
CXorf22	170063	broad.mit.edu	37	chrX	35959432	35959432	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ctgtcaattggaaattgaatCagtagttaattttggcacac	8	6	2	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:35959432C>G	uc004ddj.2	+	3	493	c.434C>G	c.(433-435)TCA>TGA	p.S145*	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	145										large_intestine(1)|lung(1)|ovary(1)	3						GAAATTGAATCAGTAGTTAAT	0.358													0	0	0	0.009535	0	29	52										G	35959432	C	G	35959432	4	3	47	1	0	0	0	0	0	1	0	0	4102	838	29	1	444	1	CXorf22	23	35959432	Nonsense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	1809343	35959432	119311128	275	13756										
PLP2	5355	broad.mit.edu	37	chrX	49029745	49029745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cacctcacaggatttcttccGaaccctcatagcggcaatcc	6	16	3	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:49029745G>A	uc004dmx.2	+	3	335	c.260G>A	c.(259-261)CGA>CAA	p.R87Q		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	87	Helical; (Potential).|MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						GATTTCTTCCGAACCCTCATA	0.532													0	0	0	0.015359	0	31	47										A	49029745	G	A	49029745	3	1	47	1	0	0	0	0	1	0	0	0	12105	1058	37	1	270	1	PLP2	23	49029745	Missense_Mutation	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	13070313	49029745	106240815	276	13757										
CCNB3	85417	broad.mit.edu	37	chrX	50031856	50031856	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttcacttcagggagcactcaAaaagagatcagcttttgaag	9	8	4	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:50031856A>G	uc004dox.3	+	4	471	c.173A>G	c.(172-174)AAA>AGA	p.K58R	CCNB3_uc004doy.2_Missense_Mutation_p.K58R|CCNB3_uc004doz.2_Missense_Mutation_p.K58R|CCNB3_uc010njq.2_5'UTR	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	58					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GGAGCACTCAAAAAGAGATCA	0.413													0	0	0	0.006122	0	19	3										G	50031856	A	G	50031856	3	3	47	1	0	0	0	0	1	0	0	0	2914	14	1	5	179	5	CCNB3	23	50031856	Missense_Mutation	SNP	A	TCGA-DK-A1AD-01A-11D-A13W-08	1002111	50031856	105238704	277	13758										
KIAA2022	340533	broad.mit.edu	37	chrX	73962682	73962682	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ttgttgagctgattctcactCaaattcactgttgtctcact	6	10	4	2			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:73962682C>G	uc004eby.2	-	3	2327	c.1710G>C	c.(1708-1710)TTG>TTC	p.L570F		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	570					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GATTCTCACTCAAATTCACTG	0.418													0	0	0	0.007835	0	39	56										G	73962682	C	G	73962682	3	3	47	1	0	0	0	0	1	0	0	0	8269	825	29	1	2848	1	KIAA2022	23	73962682	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	23930826	73962682	81307878	278	13759										
STAG2	10735	broad.mit.edu	37	chrX	123190029	123190029	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	tgtgaaaatgtctatcatctGgtttattcagctcaccggcc	8	10	5	1	rs142571900		TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:123190029G>T	uc004etz.3	+	13	1587	c.1248G>T	c.(1246-1248)CTG>CTT	p.L416L	STAG2_uc004eua.2_Silent_p.L416L|STAG2_uc004eub.2_Silent_p.L416L|STAG2_uc004euc.2_Silent_p.L416L|STAG2_uc004eud.2_Silent_p.L416L|STAG2_uc004eue.2_Silent_p.L416L	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	416					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TCTATCATCTGGTTTATTCAG	0.368													1	0	3.43241e-23	0.009718	3.78029e-23	37	53										T	123190029	G	T	123190029	2	4	47	1	0	0	0	0	0	0	0	1	15242	1335	47	4		4	STAG2	23	123190029	Silent	SNP	G	TCGA-DK-A1AD-01A-11D-A13W-08	49227347	123190029	32080531	279	13760										
DCAF12L1	139170	broad.mit.edu	37	chrX	125686323	125686323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	ccgtgcccagctccagttggCgctccgtcagcagctcgggc	13	17	1	0			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:125686323C>T	uc004eul.2	-	1	520	c.269G>A	c.(268-270)CGC>CAC	p.R90H		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	90										skin(3)|ovary(1)	4						CTCCAGTTGGCGCTCCGTCAG	0.662													0	0	0	0.00499	0	16	24										T	125686323	C	T	125686323	3	4	47	1	0	0	0	0	1	0	0	0	4264	768	27	2	1126	2	DCAF12L1	23	125686323	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	2496294	125686323	29584237	280	13761										
MCF2	4168	broad.mit.edu	37	chrX	138672035	138672035	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.32258064516129	90	1.10887883889317e-22	2.94305500735584	4.0548757879125	2.37358582707073	0.467643603501177	0.68256875146656	59	cttttcaccataccagatttCaaacttgcggttatcacctt	4	12	3	1			TCGA-DK-A1AD-01A-11D-A13W-08	TCGA-DK-A1AD-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32398d56-8668-41b1-9c0b-c6aea6e3e787	c0ce73ec-2494-4119-afc7-94e51b4a3a29	g.chrX:138672035C>G	uc004fau.2	-	20	2623	c.2329G>C	c.(2329-2331)GAA>CAA	p.E777Q	MCF2_uc004fav.2_Missense_Mutation_p.E793Q|MCF2_uc011mwl.1_Missense_Mutation_p.E754Q|MCF2_uc010nsh.1_Missense_Mutation_p.E777Q|MCF2_uc011mwm.1_Missense_Mutation_p.E738Q|MCF2_uc011mwn.1_Missense_Mutation_p.E922Q|MCF2_uc004faw.2_Missense_Mutation_p.E837Q|MCF2_uc011mwo.1_Missense_Mutation_p.E853Q	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	777	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TACCAGATTTCAAACTTGCGG	0.318													0	0	0	0.021523	0	26	50										G	138672035	C	G	138672035	3	3	47	1	0	0	0	0	1	0	0	0	9378	835	29	1	500	1	MCF2	23	138672035	Missense_Mutation	SNP	C	TCGA-DK-A1AD-01A-11D-A13W-08	12985712	138672035	16598525	281	13762										
MEGF6	1953	broad.mit.edu	37	chr1	3407103	3407103	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctgcctctactagtgcctcgCtggtccaccgctccgggatg	11	16	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:3407103C>T	uc001akl.2	-	37	4842	c.4615G>A	c.(4615-4617)GCG>ACG	p.A1539T	MEGF6_uc001akk.2_Missense_Mutation_p.A1227T	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1539						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TAGTGCCTCGCTGGTCCACCG	0.672													0	0	0	0.740014	0	30	58										T	3407103	C	T	3407103	3	4	48	1	0	0	0	0	1	0	0	0	9462	797	28	2	14	2	MEGF6	1	3407103	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		3407103	245843518	1	13763										
GPR157	80045	broad.mit.edu	37	chr1	9164616	9164616	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cagcagcaacagagagagaaGagccgagttcggacggcgcg	16	10	0	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:9164616G>C	uc001apq.1	-	4	1013	c.870C>G	c.(868-870)CTC>CTG	p.L290L	GPR157_uc010oad.1_Silent_p.L225L	NM_024980	NP_079256	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	290	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		AGAGAGAGAAGAGCCGAGTTC	0.612													0	0	0	0.740014	0	19	64										C	9164616	G	C	9164616	2	2	48	1	0	0	0	0	0	0	0	1	6662	929	33	1		1	GPR157	1	9164616	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	5757513	9164616	240086005	2	13764										
PRAMEF18	391003	broad.mit.edu	37	chr1	13475073	13475073	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cagtccactaagaagagggtCtgaagagtggcagcaacttt	12	8	1	4			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:13475073C>T	uc009vnu.1	-	3	1103	c.1056G>A	c.(1054-1056)CAG>CAA	p.Q352Q		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	352											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGAAGAGGGTCTGAAGAGTGG	0.547													0	0	0	0.870114	0	145	223										T	13475073	C	T	13475073	2	4	48	1	0	0	0	0	0	0	0	1	12433	912	32	1		1	PRAMEF18	1	13475073	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	4310457	13475073	235775548	3	13765										
LPHN2	23266	broad.mit.edu	37	chr1	82456786	82456786	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agaagggtgtattccagaagGagatgttagagaaggacaaa	14	3	0	4			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:82456786G>C	uc001dit.3	+	21	4350	c.4169G>C	c.(4168-4170)GGA>GCA	p.G1390A	LPHN2_uc001dis.2_Missense_Mutation_p.G370A|LPHN2_uc001diu.2_Missense_Mutation_p.G1390A|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.G1017A	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1446	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		attccagAAGGAGATGTTAGA	0.199													0	0	0	0.335167	0	10	9										C	82456786	G	C	82456786	3	2	48	1	0	0	0	0	1	0	0	0	8916	1174	41	1	4243	1	LPHN2	1	82456786	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	68981713	82456786	166793835	4	13766										
GBP6	163351	broad.mit.edu	37	chr1	89849217	89849217	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tcttccttccataggcaaaaGaggtcttccagaggttcctg	9	11	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:89849217G>C	uc001dnf.2	+	9	1646	c.1372G>C	c.(1372-1374)GAG>CAG	p.E458Q	GBP6_uc010ost.1_Missense_Mutation_p.E328Q	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	458							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATAGGCAAAAGAGGTCTTCCA	0.408													0	0	0	0.667858	0	23	24										C	89849217	G	C	89849217	3	2	48	1	0	0	0	0	1	0	0	0	6278	943	33	1	1402	1	GBP6	1	89849217	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	7392431	89849217	159401404	5	13767										
OLFM3	118427	broad.mit.edu	37	chr1	102302527	102302527	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgtgcaaatgcaccgcccatCaggatcctgagctgagctgt	11	12	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:102302527C>T	uc001duf.2	-	2	255	c.184G>A	c.(184-186)GAT>AAT	p.D62N	OLFM3_uc001dug.2_Missense_Mutation_p.D42N|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_5'UTR|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	62						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		CACCGCCCATCAGGATCCTGA	0.488													0	0	0	0.796494	0	36	39										T	102302527	C	T	102302527	3	4	48	1	0	0	0	0	1	0	0	0	10854	826	29	1	1272	1	OLFM3	1	102302527	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	12453310	102302527	146948094	6	13768										
PDE4DIP	9659	broad.mit.edu	37	chr1	144864168	144864168	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cctggagggaaagacgttccTccctgaaatgcaagacctct	10	12	1	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:144864168T>G	uc001elw.3	-	36	6218	c.5927A>C	c.(5926-5928)GAG>GCG	p.E1976A	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E1870A|PDE4DIP_uc001elv.3_Missense_Mutation_p.E983A|PDE4DIP_uc001ema.2_Missense_Mutation_p.E163A	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1976	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AAGACGTTCCTCCCTGAAATG	0.448			T	PDGFRB	MPD								0	0	0	0.870114	0	106	453										G	144864168	T	G	144864168	3	3	48	1	0	0	0	0	1	0	0	0	11643	1551	54	5	1149	5	PDE4DIP	1	144864168	Missense_Mutation	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08	42561641	144864168	104386453	7	13769										
PDE4DIP	9659	broad.mit.edu	37	chr1	144864203	144864203	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	acctcttgctgcttctccctCaagtcttccaaaagctgctg	6	15	4	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:144864203C>G	uc001elw.3	-	36	6183	c.5892G>C	c.(5890-5892)TTG>TTC	p.L1964F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.L1858F|PDE4DIP_uc001elv.3_Missense_Mutation_p.L971F|PDE4DIP_uc001ema.2_Missense_Mutation_p.L151F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1964	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTTCTCCCTCAAGTCTTCCA	0.547			T	PDGFRB	MPD								0	0	0	0.870114	0	78	444										G	144864203	C	G	144864203	3	3	48	1	0	0	0	0	1	0	0	0	11643	825	29	1	1184	1	PDE4DIP	1	144864203	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	35	144864203	104386418	8	13770										
TNR	7143	broad.mit.edu	37	chr1	175324643	175324643	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tccagcaaaatctcaccttgCggcttccatcggtggatttg	9	12	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:175324643C>T	uc001gkp.1	-	15	3326	c.3245G>A	c.(3244-3246)CGC>CAC	p.R1082H	TNR_uc009wwu.1_Missense_Mutation_p.R1082H	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1082	Fibronectin type-III 9.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCTCACCTTGCGGCTTCCATC	0.512													0	0	0	0.804634	0	35	66										T	175324643	C	T	175324643	3	4	48	1	0	0	0	0	1	0	0	0	16335	768	27	2	859	2	TNR	1	175324643	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	30460440	175324643	73925978	9	13771										
KCNT2	343450	broad.mit.edu	37	chr1	196434452	196434452	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ataaggcatagtaatgtagaTattaaaatcaaaacttgatt	6	3	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr1:196434452T>A	uc001gtd.1	-	8	669	c.609A>T	c.(607-609)ATA>ATT	p.I203I	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.I203I|KCNT2_uc001gtf.1_Silent_p.I203I|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.I203I|KCNT2_uc009wyv.1_Silent_p.I178I	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	203	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GTAATGTAGATATTAAAATCA	0.269													0	0	0	0.217242	0	5	68										A	196434452	T	A	196434452	2	1	48	1	0	0	0	0	0	0	0	1	8092	1396	49	5		5	KCNT2	1	196434452	Silent	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08	21109809	196434452	52816169	10	13772										
SLC4A1AP	22950	broad.mit.edu	37	chr2	27898484	27898484	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tttcttgataggactggcctGattgagaagaagcgtctgaa	12	6	2	5			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:27898484G>A	uc002rlk.3	+	6	1713	c.1431G>A	c.(1429-1431)CTG>CTA	p.L477L		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	477						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGACTGGCCTGATTGAGAAGA	0.398													0	0	0	0.729181	0	30	61										A	27898484	G	A	27898484	2	1	48	1	0	0	0	0	0	0	0	1	14653	1277	45	1		1	SLC4A1AP	2	27898484	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		27898484	215300889	11	13773										
EFEMP1	2202	broad.mit.edu	37	chr2	56108800	56108800	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gagggcactgacatgcaaagGatccccgtaaattgatgcac	11	10	0	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:56108800G>T	uc002rzh.2	-	5	917	c.587C>A	c.(586-588)TCC>TAC	p.S196Y	EFEMP1_uc002rzi.2_Missense_Mutation_p.S196Y|EFEMP1_uc002rzj.2_Missense_Mutation_p.S196Y|EFEMP1_uc010ypc.1_Missense_Mutation_p.S138Y	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	196	EGF-like 2; calcium-binding (Potential).				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACATGCAAAGGATCCCCGTAA	0.507													1	0	7.76418e-22	0.693898	8.48756e-22	27	48										T	56108800	G	T	56108800	3	4	48	1	0	0	0	0	1	0	0	0	4941	1174	41	3	922	3	EFEMP1	2	56108800	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	28210316	56108800	187090573	12	13774										
ATOH8	84913	broad.mit.edu	37	chr2	85982034	85982034	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggcgaacgccagggagcggaCgcgggtgcacaccatcagcg	17	13	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:85982034C>G	uc002sqn.2	+	1	1126	c.722C>G	c.(721-723)ACG>AGG	p.T241R	ATOH8_uc002sqm.3_Missense_Mutation_p.T241R	NM_032827	NP_116216	Q96SQ7	ATOH8_HUMAN	atonal homolog 8	241	Basic motif.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						AGGGAGCGGACGCGGGTGCAC	0.706													0	0	0	0.870114	0	70	101										G	85982034	C	G	85982034	3	3	48	1	0	0	0	0	1	0	0	0	1114	536	19	4	724	4	ATOH8	2	85982034	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	29873234	85982034	157217339	13	13775										
LYG2	254773	broad.mit.edu	37	chr2	99858848	99858848	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tagaagctttgtcttttataGaacttagctcgagcaatgat	8	6	1	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:99858848G>T	uc002szw.1	-	6	731	c.618C>A	c.(616-618)TTC>TTA	p.F206L	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_3'UTR	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	lysozyme G-like 2 precursor	206					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1						GTCTTTTATAGAACTTAGCTC	0.463													1	0	1.4709e-25	0.870114	1.64891e-25	58	100										T	99858848	G	T	99858848	3	4	48	1	0	0	0	0	1	0	0	0	9105	933	33	3	24	3	LYG2	2	99858848	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	13876814	99858848	143340525	14	13776										
GCC2	9648	broad.mit.edu	37	chr2	109103046	109103046	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgcggaacagcaccagcgtaCgctaagtgcataccagcaga	11	12	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:109103046C>T	uc002tec.2	+	16	4026	c.3872C>T	c.(3871-3873)ACG>ATG	p.T1291M	GCC2_uc002ted.2_Missense_Mutation_p.T1190M	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1291	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						CACCAGCGTACGCTAAGTGCA	0.502													0	0	0	0.812448	0	40	43										T	109103046	C	T	109103046	3	4	48	1	0	0	0	0	1	0	0	0	6286	536	19	2	3934	2	GCC2	2	109103046	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	9244198	109103046	134096327	15	13777										
NFE2L2	4780	broad.mit.edu	37	chr2	178098953	178098953	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	caaatacttctcgacttactCcaagatctatatcttgcctc	3	13	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:178098953C>G	uc002ulh.3	-	2	647	c.92G>C	c.(91-93)GGA>GCA	p.G31A	NFE2L2_uc002ulg.3_Missense_Mutation_p.G15A|NFE2L2_uc010zfa.1_Missense_Mutation_p.G15A|NFE2L2_uc002uli.3_Missense_Mutation_p.G15A|NFE2L2_uc010fra.2_Missense_Mutation_p.G15A|NFE2L2_uc010frb.2_Missense_Mutation_p.G15A	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	31					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G31R(1)		central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCGACTTACTCCAAGATCTAT	0.363			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.608945	0	22	39										G	178098953	C	G	178098953	3	3	48	1	0	0	0	0	1	0	0	0	10368	855	30	1	1741	1	NFE2L2	2	178098953	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	68995907	178098953	65100420	16	13778										
TTN	7273	broad.mit.edu	37	chr2	179412782	179412782	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gggttcactatagccagcatCattcttggccttcacacgga	9	12	4	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179412782C>T	uc010zfg.1	-	288	86091	c.85867G>A	c.(85867-85869)GAT>AAT	p.D28623N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22318N|TTN_uc010zfi.1_Missense_Mutation_p.D22251N|TTN_uc010zfj.1_Missense_Mutation_p.D22126N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29550							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGCCAGCATCATTCTTGGCC	0.458													0	0	0	0.750413	0	34	68										T	179412782	C	T	179412782	3	4	48	1	0	0	0	0	1	0	0	0	16732	826	29	1	14504	1	TTN	2	179412782	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	1313829	179412782	63786591	17	13779			1	51		5	5	646	C		2.981691e-12
TTN	7273	broad.mit.edu	37	chr2	179412881	179412881	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	accagcttcaacccagaagtCagatcccttttgtctcattt	5	13	3	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179412881C>G	uc010zfg.1	-	288	85992	c.85768G>C	c.(85768-85770)GAC>CAC	p.D28590H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22285H|TTN_uc010zfi.1_Missense_Mutation_p.D22218H|TTN_uc010zfj.1_Missense_Mutation_p.D22093H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29517							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCCAGAAGTCAGATCCCTTT	0.468													0	0	0	0.870114	0	88	163										G	179412881	C	G	179412881	3	3	48	1	0	0	0	0	1	0	0	0	16732	826	29	1	14603	1	TTN	2	179412881	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	99	179412881	63786492	18	13780			1	51		5	5	646	C		2.981691e-12
TTN	7273	broad.mit.edu	37	chr2	179412928	179412928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggtagccagtgatccggctgCctccatcgtggtcaggttta	13	11	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179412928C>T	uc010zfg.1	-	288	85945	c.85721G>A	c.(85720-85722)GGC>GAC	p.G28574D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G22269D|TTN_uc010zfi.1_Missense_Mutation_p.G22202D|TTN_uc010zfj.1_Missense_Mutation_p.G22077D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29501							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCCGGCTGCCTCCATCGTG	0.498													0	0	0	0.870114	0	74	130										T	179412928	C	T	179412928	3	4	48	1	0	0	0	0	1	0	0	0	16732	739	26	2	14650	2	TTN	2	179412928	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	47	179412928	63786445	19	13781			1	51		5	5	646	C		2.981691e-12
TTN	7273	broad.mit.edu	37	chr2	179413248	179413248	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agaagaggggcatcccacatCaatgtagcagatccccgggt	12	11	1	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179413248C>T	uc010zfg.1	-	288	85625	c.85401G>A	c.(85399-85401)TTG>TTA	p.L28467L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L22162L|TTN_uc010zfi.1_Silent_p.L22095L|TTN_uc010zfj.1_Silent_p.L21970L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29394							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCCCACATCAATGTAGCAG	0.507													0	0	0	0.870114	0	99	175										T	179413248	C	T	179413248	2	4	48	1	0	0	0	0	0	0	0	1	16732	825	29	1		1	TTN	2	179413248	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	320	179413248	63786125	20	13782			1	51		5	5	646	C		2.981691e-12
TTN	7273	broad.mit.edu	37	chr2	179413427	179413427	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agtgagggtgctgaaggaatCtgttgtatggatatcagccc	14	6	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:179413427C>T	uc010zfg.1	-	288	85446	c.85222G>A	c.(85222-85224)GAT>AAT	p.D28408N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D22103N|TTN_uc010zfi.1_Missense_Mutation_p.D22036N|TTN_uc010zfj.1_Missense_Mutation_p.D21911N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29335							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAAGGAATCTGTTGTATGG	0.448													0	0	0	0.812448	0	38	72										T	179413427	C	T	179413427	3	4	48	1	0	0	0	0	1	0	0	0	16732	913	32	1	15149	1	TTN	2	179413427	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	179	179413427	63785946	21	13783			1	51		5	5	646	C		2.981691e-12
SF3B1	23451	broad.mit.edu	37	chr2	198267484	198267484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agctctagctgttgtgttacGgacatactcatccatgttat	8	9	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:198267484G>A	uc002uue.2	-	14	1921	c.1873C>T	c.(1873-1875)CGT>TGT	p.R625C		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	625	HEAT 3.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTTGTGTTACGGACATACTCA	0.433													0	0	0	0.740014	0	30	49										A	198267484	G	A	198267484	3	1	48	1	0	0	0	0	1	0	0	0	14149	1116	39	2	2089	2	SF3B1	2	198267484	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	18854057	198267484	44931889	22	13784										
NIF3L1	60491	broad.mit.edu	37	chr2	201756682	201756682	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tctgtatgttgtcatcttgcGtacgcccagtccccacgaca	8	14	3	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:201756682G>A	uc002uwm.2	+	2	107	c.16G>A	c.(16-18)GTA>ATA	p.V6I	PPIL3_uc002uwh.2_5'Flank|PPIL3_uc002uwi.2_5'Flank|PPIL3_uc002uwj.2_5'Flank|PPIL3_uc002uwk.2_5'Flank|NIF3L1_uc002uwl.2_Intron|NIF3L1_uc002uwn.2_Intron|NIF3L1_uc002uwo.2_Missense_Mutation_p.V6I|NIF3L1_uc002uwp.2_Missense_Mutation_p.V6I|NIF3L1_uc002uwq.2_Missense_Mutation_p.V6I	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	6					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						GTCATCTTGCGTACGCCCAGT	0.438													0	0	0	0.457914	0	15	24										A	201756682	G	A	201756682	3	1	48	1	0	0	0	0	1	0	0	0	10416	1145	40	2	18	2	NIF3L1	2	201756682	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	3489198	201756682	41442691	23	13785										
USP37	57695	broad.mit.edu	37	chr2	219360635	219360635	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aatttttccatatcttctttCagctggtccaaacactgact	4	11	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:219360635C>A	uc002vie.2	-	14	1773	c.1320G>T	c.(1318-1320)CTG>CTT	p.L440L	USP37_uc010fvs.1_Silent_p.L440L|USP37_uc010zkf.1_Silent_p.L440L|USP37_uc002vif.2_Silent_p.L440L|USP37_uc002vig.2_Silent_p.L368L	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	440					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TATCTTCTTTCAGCTGGTCCA	0.338													1	0	4.62619e-21	0.796494	5.02598e-21	36	63										A	219360635	C	A	219360635	2	1	48	1	0	0	0	0	0	0	0	1	17065	813	29	3		3	USP37	2	219360635	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	17603953	219360635	23838738	24	13786										
ZNF142	7701	broad.mit.edu	37	chr2	219503085	219503085	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gccctcaggtccagtgtgggGagcggcaggagcaggagggc	20	10	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:219503085G>C	uc002vin.2	-	10	5477	c.5041C>G	c.(5041-5043)CCC>GCC	p.P1681A	ZNF142_uc002vil.2_Missense_Mutation_p.P1642A|ZNF142_uc010fvt.2_Missense_Mutation_p.P1518A|ZNF142_uc002vim.2_Missense_Mutation_p.P1518A	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1681					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CCAGTGTGGGGAGCGGCAGGA	0.627													0	0	0	0.557998	0	14	26										C	219503085	G	C	219503085	3	2	48	1	0	0	0	0	1	0	0	0	17728	1174	41	1	26	1	ZNF142	2	219503085	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	142450	219503085	23696288	25	13787										
ZNF142	7701	broad.mit.edu	37	chr2	219503172	219503172	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggggtctttgcccacaccctGgtttgggtcggcttggtcag	15	11	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:219503172G>A	uc002vin.2	-	10	5390	c.4954C>T	c.(4954-4956)CAG>TAG	p.Q1652*	ZNF142_uc002vil.2_Nonsense_Mutation_p.Q1613*|ZNF142_uc010fvt.2_Nonsense_Mutation_p.Q1489*|ZNF142_uc002vim.2_Nonsense_Mutation_p.Q1489*	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1652					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CCCACACCCTGGTTTGGGTCG	0.622													0	0	0	0.788014	0	30	66										A	219503172	G	A	219503172	4	1	48	1	0	0	0	0	0	1	0	0	17728	1357	47	2	113	2	ZNF142	2	219503172	Nonsense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	87	219503172	23696201	26	13788										
INHA	3623	broad.mit.edu	37	chr2	220439578	220439578	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggacaggcagggcacagcagCctccaatagctctgagcccc	12	15	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:220439578C>A	uc002vmk.1	+	2	575	c.431C>A	c.(430-432)GCC>GAC	p.A144D		NM_002191	NP_002182	P05111	INHA_HUMAN	inhibin alpha subunit precursor	144					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGCACAGCAGCCTCCAATAGC	0.642													1	0	7.34454e-26	0.870114	8.28615e-26	52	61										A	220439578	C	A	220439578	3	1	48	1	0	0	0	0	1	0	0	0	7740	739	26	4	437	4	INHA	2	220439578	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	936406	220439578	22759795	27	13789										
DOCK10	55619	broad.mit.edu	37	chr2	225653783	225653783	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agataattttggtctaacctCattgtatggtgtatcttgca	8	6	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:225653783C>G	uc010fwz.1	-	48	5655	c.5416G>C	c.(5416-5418)GAG>CAG	p.E1806Q	DOCK10_uc002vob.2_Missense_Mutation_p.E1800Q|DOCK10_uc002voa.2_Missense_Mutation_p.E462Q|DOCK10_uc002voc.2_Missense_Mutation_p.E627Q	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1806	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GGTCTAACCTCATTGTATGGT	0.393													0	0	0	0.217242	0	6	21										G	225653783	C	G	225653783	3	3	48	1	0	0	0	0	1	0	0	0	4685	835	29	1	1180	1	DOCK10	2	225653783	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	5214205	225653783	17545590	28	13790										
SP140	11262	broad.mit.edu	37	chr2	231113635	231113635	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aaactccccaagtcactaatGaaggagaaccagagaagggg	11	9	1	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:231113635G>A	uc002vql.2	+	9	1043	c.928G>A	c.(928-930)GAA>AAA	p.E310K	SP140_uc010zma.1_RNA|SP140_uc002vqk.2_Missense_Mutation_p.E310K|SP140_uc002vqn.2_Missense_Mutation_p.E257K|SP140_uc002vqm.2_Missense_Mutation_p.E284K|SP140_uc010fxl.2_Missense_Mutation_p.E310K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	310					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTCACTAATGAAGGAGAACC	0.398													0	0	0	0.740014	0	30	66										A	231113635	G	A	231113635	3	1	48	1	0	0	0	0	1	0	0	0	14962	1291	45	1	1079	1	SP140	2	231113635	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	5459852	231113635	12085738	29	13791										
PSMD1	5707	broad.mit.edu	37	chr2	231947666	231947666	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctgcacgtcaagatgtttatGatttgctaaaaacaaacctt	6	8	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr2:231947666G>A	uc002vrn.1	+	13	1614	c.1483G>A	c.(1483-1485)GAT>AAT	p.D495N	PSMD1_uc002vrm.1_Missense_Mutation_p.D495N|PSMD1_uc010fxu.1_Missense_Mutation_p.D359N	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	495	PC 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	AGATGTTTATGATTTGCTAAA	0.363													0	0	0	0.681144	0	25	40										A	231947666	G	A	231947666	3	1	48	1	0	0	0	0	1	0	0	0	12692	1290	45	1	1533	1	PSMD1	2	231947666	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	834031	231947666	11251707	30	13792										
IL5RA	3568	broad.mit.edu	37	chr3	3144421	3144421	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	attaacattcctttgctcttGatcaggatttggtttccatt	6	8	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:3144421G>C	uc011ask.1	-	5	810	c.166C>G	c.(166-168)CAA>GAA	p.Q56E	IL5RA_uc010hbq.2_Missense_Mutation_p.Q56E|IL5RA_uc010hbr.2_Missense_Mutation_p.Q56E|IL5RA_uc010hbs.2_Missense_Mutation_p.Q56E|IL5RA_uc011asl.1_Missense_Mutation_p.Q56E|IL5RA_uc011asm.1_Missense_Mutation_p.Q56E|IL5RA_uc010hbt.2_Missense_Mutation_p.Q56E|IL5RA_uc011asn.1_Missense_Mutation_p.Q56E|IL5RA_uc010hbu.2_Missense_Mutation_p.Q56E	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	56	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		CTTTGCTCTTGATCAGGATTT	0.333													0	0	0	0.575678	0	20	27										C	3144421	G	C	3144421	3	2	48	1	0	0	0	0	1	0	0	0	7700	1299	45	1	1158	1	IL5RA	3	3144421	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		3144421	194878009	31	13793										
SCN10A	6336	broad.mit.edu	37	chr3	38739749	38739749	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gccgacgtggtaatctggaaGaggcacagcatgctgttggc	15	9	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:38739749G>A	uc003ciq.2	-	27	4962	c.4962C>T	c.(4960-4962)CTC>CTT	p.L1654L		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1654	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TAATCTGGAAGAGGCACAGCA	0.582													0	0	0	0.870114	0	48	88										A	38739749	G	A	38739749	2	1	48	1	0	0	0	0	0	0	0	1	13912	929	33	1		1	SCN10A	3	38739749	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	35595328	38739749	159282681	32	13794										
PROS1	5627	broad.mit.edu	37	chr3	93646147	93646147	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttcttctttattgcacagttCttcgatgcattctctttcaa	4	10	5	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:93646147C>T	uc003drb.3	-	2	522	c.181G>A	c.(181-183)GAA>AAA	p.E61K	PROS1_uc010hoo.2_5'UTR|PROS1_uc003dqz.3_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	61	Gla.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTGCACAGTTCTTCGATGCAT	0.413													0	0	0	0.740014	0	31	75										T	93646147	C	T	93646147	3	4	48	1	0	0	0	0	1	0	0	0	12558	922	32	1	1905	1	PROS1	3	93646147	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	54906398	93646147	104376283	33	13795										
IFT122	55764	broad.mit.edu	37	chr3	129195584	129195584	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	atgggctttacaaggaccgcTatgcctacagggatagcatg	12	9	0	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:129195584T>A	uc003emm.2	+	11	1293	c.1087T>A	c.(1087-1089)TAT>AAT	p.Y363N	IFT122_uc003eml.2_Missense_Mutation_p.Y414N|IFT122_uc003emn.2_Missense_Mutation_p.Y304N|IFT122_uc003emo.2_Missense_Mutation_p.Y252N|IFT122_uc003emp.2_Missense_Mutation_p.Y213N|IFT122_uc010htc.2_Missense_Mutation_p.Y355N|IFT122_uc011bky.1_Missense_Mutation_p.Y154N|IFT122_uc003emq.2_Missense_Mutation_p.Y203N|IFT122_uc003emr.2_Missense_Mutation_p.Y154N|IFT122_uc011bla.1_Missense_Mutation_p.Y154N|IFT122_uc011bkx.1_Missense_Mutation_p.Y203N|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	363					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CAAGGACCGCTATGCCTACAG	0.547													0	0	0	0.870114	0	54	89										A	129195584	T	A	129195584	3	1	48	1	0	0	0	0	1	0	0	0	7555	1522	53	5	1286	5	IFT122	3	129195584	Missense_Mutation	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08	35549437	129195584	68826846	34	13796										
ABCC5	10057	broad.mit.edu	37	chr3	183689484	183689484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggaggtggcctttctgctctGccagcaccgcctgatgctca	12	14	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:183689484G>A	uc003fmg.2	-	11	1793	c.1628C>T	c.(1627-1629)GCA>GTA	p.A543V	ABCC5_uc011bqt.1_Missense_Mutation_p.A71V|ABCC5_uc010hxl.2_Missense_Mutation_p.A543V	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	543						integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTTCTGCTCTGCCAGCACCGC	0.597													0	0	0	0.870114	0	49	100										A	183689484	G	A	183689484	3	1	48	1	0	0	0	0	1	0	0	0	56	1319	46	2	2765	2	ABCC5	3	183689484	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	54493900	183689484	14332946	35	13797										
C3orf59	151963	broad.mit.edu	37	chr3	192516318	192516318	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	atcaggctggttggggtcccCtccgtcagactgtggagagg	16	10	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr3:192516318C>G	uc011bsp.1	-	2	1654	c.1333G>C	c.(1333-1335)GGG>CGG	p.G445R		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	445											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGGGGTCCCCTCCGTCAGAC	0.567													0	0	0	0.870114	0	69	217										G	192516318	C	G	192516318	3	3	48	1	0	0	0	0	1	0	0	0	2237	681	24	4	146	4	C3orf59	3	192516318	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	8826834	192516318	5506112	36	13798										
PPARGC1A	10891	broad.mit.edu	37	chr4	23814419	23814419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcttggccctctcagactctCgcttctcatactctctgcga	7	16	4	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:23814419C>T	uc003gqs.2	-	10	2090	c.1970G>A	c.(1969-1971)CGA>CAA	p.R657Q	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	657					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CTCAGACTCTCGCTTCTCATA	0.453													0	0	0	0.870114	0	68	97										T	23814419	C	T	23814419	3	4	48	1	0	0	0	0	1	0	0	0	12300	884	31	1	442	1	PPARGC1A	4	23814419	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		23814419	167339857	37	13799										
PPARGC1A	10891	broad.mit.edu	37	chr4	23815883	23815883	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	catctttattttctagttgtCtagagtcttggagctcctgt	8	8	4	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:23815883C>G	uc003gqs.2	-	8	1343	c.1223G>C	c.(1222-1224)AGA>ACA	p.R408T	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	408					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				TTCTAGTTGTCTAGAGTCTTG	0.448													0	0	0	0.608945	0	22	40										G	23815883	C	G	23815883	3	3	48	1	0	0	0	0	1	0	0	0	12300	913	32	1	1197	1	PPARGC1A	4	23815883	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	1464	23815883	167338393	38	13800										
SDAD1	55153	broad.mit.edu	37	chr4	76882456	76882456	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctgttatctcctttatagcaTtgattctagaaaaagaaaaa	5	6	2	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:76882456T>C	uc003hje.3	-	15	1306	c.1187A>G	c.(1186-1188)AAT>AGT	p.N396S	SDAD1_uc003hjf.3_Missense_Mutation_p.N299S|SDAD1_uc011cbr.1_Missense_Mutation_p.N359S	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	396				N -> S (in Ref. 1; CAH18368).	protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTTATAGCATTGATTCTAGA	0.368													0	0	0	0.864702	0	44	59										C	76882456	T	C	76882456	3	2	48	1	0	0	0	0	1	0	0	0	13950	1493	52	5	908	5	SDAD1	4	76882456	Missense_Mutation	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08	53066573	76882456	114271820	39	13801										
GAB1	2549	broad.mit.edu	37	chr4	144359278	144359278	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggcttttttcagcagcaaatGatatacgactctccaccttc	6	12	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:144359278G>A	uc003ije.2	+	4	1079	c.720G>A	c.(718-720)ATG>ATA	p.M240I	GAB1_uc003ijd.2_Missense_Mutation_p.M240I|GAB1_uc011chq.1_Missense_Mutation_p.M137I	NM_002039	NP_002030	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1 isoform b	240					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(2)|lung(1)|skin(1)	4	all_hematologic(180;0.158)					AGCAGCAAATGATATACGACT	0.448													0	0	0	0.654019	0	23	42										A	144359278	G	A	144359278	3	1	48	1	0	0	0	0	1	0	0	0	6148	1290	45	1	734	1	GAB1	4	144359278	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	67476822	144359278	46794998	40	13802										
FGG	2266	broad.mit.edu	37	chr4	155530854	155530854	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aagaattgctggttagctttCagaggtttaataaagtaaag	10	3	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:155530854C>T	uc003ioj.2	-	6	735	c.594G>A	c.(592-594)CTG>CTA	p.L198L	FGG_uc003iog.2_Silent_p.L198L|FGG_uc003ioh.2_Silent_p.L206L|FGG_uc010ipx.2_Silent_p.L26L|FGG_uc010ipy.2_5'UTR|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Silent_p.L206L	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	198	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GGTTAGCTTTCAGAGGTTTAA	0.393													0	0	0	0.796494	0	36	76										T	155530854	C	T	155530854	2	4	48	1	0	0	0	0	0	0	0	1	5870	813	29	1		1	FGG	4	155530854	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	11171576	155530854	35623422	41	13803										
KIAA1430	57587	broad.mit.edu	37	chr4	186111887	186111887	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgctttttttaacgttagtaGatggtttagcggacttggac	11	5	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr4:186111887G>C	uc003ixf.3	-	2	611	c.464C>G	c.(463-465)TCT>TGT	p.S155C	KIAA1430_uc003ixg.2_Missense_Mutation_p.S155C	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	155											0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		AACGTTAGTAGATGGTTTAGC	0.299													0	0	0	0.27861	0	7	15										C	186111887	G	C	186111887	3	2	48	1	0	0	0	0	1	0	0	0	8232	942	33	1	1150	1	KIAA1430	4	186111887	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	30581033	186111887	5042389	42	13804										
POLK	51426	broad.mit.edu	37	chr5	74865308	74865308	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cccattgctgtaggatcaatGagtatgctggtaagtaaaga	11	6	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:74865308G>C	uc003kdw.2	+	4	495	c.399G>C	c.(397-399)ATG>ATC	p.M133I	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kdz.2_Missense_Mutation_p.M133I|POLK_uc003kea.2_Missense_Mutation_p.M133I|POLK_uc003keb.2_Missense_Mutation_p.M133I|POLK_uc010izq.2_Missense_Mutation_p.M133I|POLK_uc003kec.2_Missense_Mutation_p.M43I|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.M43I|POLK_uc003kee.2_Missense_Mutation_p.M133I|POLK_uc003kef.2_Missense_Mutation_p.M43I	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	133	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TAGGATCAATGAGTATGCTGG	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.592651	0	20	33										C	74865308	G	C	74865308	3	2	48	1	0	0	0	0	1	0	0	0	12204	1290	45	1	409	1	POLK	5	74865308	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		74865308	106049952	43	13805										
PSD2	84249	broad.mit.edu	37	chr5	139215325	139215325	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cagaccctttacaactccatCaagaatgaaaagctggaatg	7	10	1	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:139215325C>G	uc003leu.1	+	9	1582	c.1377C>G	c.(1375-1377)ATC>ATG	p.I459M		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	459	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACTCCATCAAGAATGAAA	0.527													0	0	0	0.870114	0	287	476										G	139215325	C	G	139215325	3	3	48	1	0	0	0	0	1	0	0	0	12647	816	29	1	1407	1	PSD2	5	139215325	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	64350017	139215325	41699935	44	13806										
PCDHB3	56132	broad.mit.edu	37	chr5	140482583	140482583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agggtgcagagagggttagcGaggcaaatcccagtttcagg	16	7	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:140482583G>A	uc003lio.2	+	1	2350	c.2350G>A	c.(2350-2352)GAG>AAG	p.E784K	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	784	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGGTTAGCGAGGCAAATCC	0.458													0	0	0	0.870114	0	105	187										A	140482583	G	A	140482583	3	1	48	1	0	0	0	0	1	0	0	0	11543	1059	37	1	2352	1	PCDHB3	5	140482583	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	1267258	140482583	40432677	45	13807										
NSD1	64324	broad.mit.edu	37	chr5	176709524	176709524	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgaagaagaatgcagagctcGaattcgctatgctcaagaac	10	8	1	5			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr5:176709524G>T	uc003mfr.3	+	19	6089	c.5951G>T	c.(5950-5952)CGA>CTA	p.R1984L	NSD1_uc003mft.3_Missense_Mutation_p.R1715L|NSD1_uc011dfx.1_Missense_Mutation_p.R1632L	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1984	SET.		R -> Q (in SOTOSS; loss of enzyme activity).		negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TGCAGAGCTCGAATTCGCTAT	0.373			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			1	0	4.09166e-32	0.870114	4.67618e-32	76	111										T	176709524	G	T	176709524	3	4	48	1	0	0	0	0	1	0	0	0	10669	1058	37	3	6021	3	NSD1	5	176709524	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	36226941	176709524	4205736	46	13808										
BRD2	6046	broad.mit.edu	37	chr6	32944408	32944408	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ccatcttggctcctggttctCcagctagccctcctgggagt	10	15	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:32944408C>T	uc003ocn.3	+	7	2596	c.895C>T	c.(895-897)CCA>TCA	p.P299S	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.P299S|BRD2_uc003ocp.3_Missense_Mutation_p.P179S|BRD2_uc010juh.2_Missense_Mutation_p.P299S	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	299					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TCCTGGTTCTCCAGCTAGCCC	0.552													0	0	0	0.870114	0	82	141										T	32944408	C	T	32944408	3	4	48	1	0	0	0	0	1	0	0	0	1502	855	30	1	917	1	BRD2	6	32944408	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		32944408	138170659	47	13809										
MAPK14	1432	broad.mit.edu	37	chr6	36067964	36067964	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcccttgactaggcatctaaGatattaaccagcttcagcag	8	11	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:36067964G>A	uc003olp.2	+	9	1164	c.683_splice	c.e9-1	p.H228_splice	MAPK14_uc003olo.2_Intron|MAPK14_uc003olq.2_Intron|MAPK14_uc003olr.2_Intron|MAPK14_uc011dti.1_Intron	NM_001315	NP_001306	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14 isoform 1						activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			ovary(2)|stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	6						AGGCATCTAAGATATTAACCA	0.403													0	0	0	0.870114	0	63	108										A	36067964	G	A	36067964	5	1	48	1	0	0	0	0	0	0	1	0	9276	956	33	1	800	1	MAPK14	6	36067964	Splice_Site	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	3123556	36067964	135047103	48	13810										
MRPL14	64928	broad.mit.edu	37	chr6	44081613	44081613	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgagcaatggccagcaccttGgaatactcgccttcccgctt	9	14	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:44081613G>A	uc003owp.2	-	3	534	c.405C>T	c.(403-405)TCC>TCT	p.S135S		NM_032111	NP_115487	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14 precursor	135					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			CCAGCACCTTGGAATACTCGC	0.552													0	0	0	0.859065	0	46	63										A	44081613	G	A	44081613	2	1	48	1	0	0	0	0	0	0	0	1	9779	1335	47	2		2	MRPL14	6	44081613	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	8013649	44081613	127033454	49	13811										
MDN1	23195	broad.mit.edu	37	chr6	90428326	90428326	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	accttctctagcagcctcctCcaaggtcgtataagatcaac	6	14	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:90428326C>T	uc003pnn.1	-	43	6458	c.6342G>A	c.(6340-6342)TGG>TGA	p.W2114*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2114					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCAGCCTCCTCCAAGGTCGTA	0.473													0	0	0	0.706142	0	26	53										T	90428326	C	T	90428326	4	4	48	1	0	0	0	0	0	1	0	0	9415	856	30	1	10688	1	MDN1	6	90428326	Nonsense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	46346713	90428326	80686741	50	13812										
TNFAIP3	7128	broad.mit.edu	37	chr6	138192400	138192400	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cttcctcaggctttgtatttGagcaatatgcggaaagctgt	10	8	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr6:138192400G>C	uc003qhr.2	+	2	102	c.36G>C	c.(34-36)TTG>TTC	p.L12F	TNFAIP3_uc003qhs.2_Missense_Mutation_p.L12F	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	12					anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CTTTGTATTTGAGCAATATGC	0.388			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma						OREG0031869	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.870114	0	88	136										C	138192400	G	C	138192400	3	2	48	1	0	0	0	0	1	0	0	0	16271	1281	45	1	38	1	TNFAIP3	6	138192400	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	47764074	138192400	32922667	51	13813										
MAGI2	9863	broad.mit.edu	37	chr7	77797280	77797280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgaggttgacctgcccattgCgggctgcgtggtgcatgagg	17	9	0	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:77797280C>T	uc003ugx.2	-	15	2803	c.2549G>A	c.(2548-2550)CGC>CAC	p.R850H	MAGI2_uc003ugy.2_Missense_Mutation_p.R836H|MAGI2_uc010ldx.1_Missense_Mutation_p.R443H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	850	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGCCCATTGCGGGCTGCGTG	0.547													0	0	0	0.870114	0	82	145										T	77797280	C	T	77797280	3	4	48	1	0	0	0	0	1	0	0	0	9191	768	27	2	1850	2	MAGI2	7	77797280	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		77797280	81341383	52	13814										
CNPY4	245812	broad.mit.edu	37	chr7	99722457	99722457	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gaggaggaagaggaagggggAgacaagatgaccaagacagg	19	4	0	5			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:99722457A>G	uc003uto.2	+	6	796	c.693A>G	c.(691-693)GGA>GGG	p.G231G	MBLAC1_uc003utp.2_5'Flank	NM_152755	NP_689968	Q8N129	CNPY4_HUMAN	canopy 4 homolog precursor	231						extracellular region					0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					aggaaggggGAGACAAGATGA	0.388													0	0	0	0.870114	0	181	260										G	99722457	A	G	99722457	2	3	48	1	0	0	0	0	0	0	0	1	3630	291	11	5		5	CNPY4	7	99722457	Silent	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	21925177	99722457	59416206	53	13815										
LMOD2	442721	broad.mit.edu	37	chr7	123302716	123302716	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggataaacagaggcaaaaacGtttgcaggagcaaaaacagc	11	7	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:123302716G>A	uc003vky.2	+	2	1233	c.1076G>A	c.(1075-1077)CGT>CAT	p.R359H		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	359						cytoskeleton	actin binding|tropomyosin binding				0						AGGCAAAAACGTTTGCAGGAG	0.463													0	0	0	0.870114	0	58	77										A	123302716	G	A	123302716	3	1	48	1	0	0	0	0	1	0	0	0	8857	1145	40	2	1082	2	LMOD2	7	123302716	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	23580259	123302716	35835947	54	13816										
MLL3	58508	broad.mit.edu	37	chr7	151873966	151873967	+	Frame_Shift_Ins	INS	-	-	AG													0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tcatttaggtctgagtgagcINSagaagcctgtgagcaaggag							TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			-	AG	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:151873966_151873967insAG	uc003wla.2	-	38	8790_8791	c.8571_8572insCT	c.(8569-8574)TCTGCTfs	p.S2857fs	MLL3_uc003wkz.2_Frame_Shift_Ins_p.S1918fs|MLL3_uc003wky.2_Frame_Shift_Ins_p.S366fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2857_2858					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTGAGTGAGCAGAAGCCTGTG	0.411			N		medulloblastoma													48	119	---	---								AG	151873967	-	AG	151873966	7	5	48	1	0	1	1	0	0	0	0	0	9622	710	25	0	6251	0	MLL3	7	151873966	Frame_Shift_Ins	INS	-	TCGA-DK-A1AE-01A-11D-A13W-08	28571250	151873966	7264697	55	13817										
UBE3C	9690	broad.mit.edu	37	chr7	157060438	157060438	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttgaatgtgccgctggctttGagctgagctgaagctgatgc	14	8	0	5			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr7:157060438G>C	uc010lqs.2	+	23	3553	c.3241G>C	c.(3241-3243)GAG>CAG	p.E1081Q	UBE3C_uc003wni.3_Missense_Mutation_p.E444Q	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	1081	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CGCTGGCTTTGAGCTGAGCTG	0.547													0	0	0	0.870114	0	104	130										C	157060438	G	C	157060438	3	2	48	1	0	0	0	0	1	0	0	0	16878	1291	45	1	3331	1	UBE3C	7	157060438	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	5186472	157060438	2078225	56	13818										
ZFHX4	79776	broad.mit.edu	37	chr8	77767336	77767336	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggggagaaagcccacagaaaTacatctattttgattaccca	8	9	1	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:77767336T>C	uc003yav.2	+	10	8431	c.8044T>C	c.(8044-8046)TAC>CAC	p.Y2682H	ZFHX4_uc003yau.1_Missense_Mutation_p.Y2727H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Y2682H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2682						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCCACAGAAATACATCTATTT	0.428										HNSCC(33;0.089)			0	0	0	0.411799	0	13	40										C	77767336	T	C	77767336	3	2	48	1	0	0	0	0	1	0	0	0	17632	1406	49	5	8213	5	ZFHX4	8	77767336	Missense_Mutation	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08		77767336	68596686	57	13819										
OSR2	116039	broad.mit.edu	37	chr8	99961401	99961402	+	Frame_Shift_Ins	INS	-	-	G													0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	accatcacggagatggcggcINSggcgcagggcctcgtggacg							TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:99961401_99961402insG	uc003yir.2	+	2	756_757	c.221_222insG	c.(220-222)GCGfs	p.A74fs	OSR2_uc010mbn.2_Frame_Shift_Ins_p.A74fs|OSR2_uc003yiq.2_Frame_Shift_Ins_p.A74fs|OSR2_uc011lgx.1_Frame_Shift_Ins_p.A195fs	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	74					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			GAGATGGCGGCGGCGCAGGGCC	0.649																		8	510	---	---								G	99961402	-	G	99961401	7	5	48	1	0	1	1	0	0	0	0	0	11294	768	27	0	223	0	OSR2	8	99961401	Frame_Shift_Ins	INS	-	TCGA-DK-A1AE-01A-11D-A13W-08	22194065	99961401	46402621	58	13820										
UBR5	51366	broad.mit.edu	37	chr8	103277452	103277452	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	atcaccatcatctgtatcatCtaaatccatatctactacac	1	13	6	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:103277452C>G	uc003ykr.1	-	53	7510	c.7477G>C	c.(7477-7479)GAT>CAT	p.D2493H	UBR5_uc003yks.1_Missense_Mutation_p.D2492H|UBR5_uc003ykq.2_Missense_Mutation_p.D4H	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2493	Asp/Glu-rich (acidic).|HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding	p.D2493V(1)		lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCTGTATCATCTAAATCCATA	0.423													0	0	0	0.870114	0	78	38										G	103277452	C	G	103277452	3	3	48	1	0	0	0	0	1	0	0	0	16902	913	32	1	950	1	UBR5	8	103277452	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	3316051	103277452	43086570	59	13821										
ODF1	4956	broad.mit.edu	37	chr8	103564035	103564035	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agaactaaggcaactgagatGcatcgacgaatttagcacac	9	9	0	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:103564035G>T	uc003ykt.2	+	1	188	c.80G>T	c.(79-81)TGC>TTC	p.C27F		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	27					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			CAACTGAGATGCATCGACGAA	0.483													1	0	3.12118e-38	0.870114	3.614e-38	79	285										T	103564035	G	T	103564035	3	4	48	1	0	0	0	0	1	0	0	0	10826	1319	46	4	82	4	ODF1	8	103564035	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	286583	103564035	42799987	60	13822										
AZIN1	51582	broad.mit.edu	37	chr8	103851004	103851004	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgattacgtgcaattttcttCaattcaatttcattgtcaca	4	8	5	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:103851004C>T	uc003ykx.2	-	6	1159	c.417G>A	c.(415-417)TTG>TTA	p.L139L	AZIN1_uc003yky.2_Silent_p.L139L	NM_015878	NP_056962	O14977	AZIN1_HUMAN	ornithine decarboxylase antizyme inhibitor	139					polyamine biosynthetic process|regulation of cellular amino acid metabolic process	cytosol	catalytic activity|protein binding				0	Lung NSC(17;0.000143)|all_lung(17;0.000294)		OV - Ovarian serous cystadenocarcinoma(57;0.000196)|STAD - Stomach adenocarcinoma(118;0.0414)			CAATTTTCTTCAATTCAATTT	0.328													0	0	0	0.624587	0	22	79										T	103851004	C	T	103851004	2	4	48	1	0	0	0	0	0	0	0	1	1242	825	29	1		1	AZIN1	8	103851004	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	286969	103851004	42513018	61	13823										
CSMD3	114788	broad.mit.edu	37	chr8	113694715	113694715	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tccacattacttttccatccAtaagaatacatgtaattgtt	3	9	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:113694715A>C	uc003ynu.2	-	16	2792	c.2633T>G	c.(2632-2634)ATG>AGG	p.M878R	CSMD3_uc003yns.2_Missense_Mutation_p.M150R|CSMD3_uc003ynt.2_Missense_Mutation_p.M838R|CSMD3_uc011lhx.1_Missense_Mutation_p.M774R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	878	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTTTCCATCCATAAGAATACA	0.358										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.870114	0	53	114										C	113694715	A	C	113694715	3	2	48	1	0	0	0	0	1	0	0	0	3946	217	8	5	8714	5	CSMD3	8	113694715	Missense_Mutation	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	9843711	113694715	32669307	62	13824										
TAF2	6873	broad.mit.edu	37	chr8	120807793	120807793	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tctttaatccaatggcggtaCtcattaacaccaaaagtttt	5	9	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:120807793C>A	uc003you.2	-	9	1440	c.1170G>T	c.(1168-1170)GAG>GAT	p.E390D		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	390					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AATGGCGGTACTCATTAACAC	0.343													1	0	8.60227e-14	0.500413	8.95858e-14	17	74										A	120807793	C	A	120807793	3	1	48	1	0	0	0	0	1	0	0	0	15521	564	20	4	2501	4	TAF2	8	120807793	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	7113078	120807793	25556229	63	13825										
BAI1	575	broad.mit.edu	37	chr8	143565371	143565371	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tccttagcaacctgttggcaGaggagaatcgggacaagtgg	14	8	0	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:143565371G>C	uc003ywm.2	+	11	2347	c.2164G>C	c.(2164-2166)GAG>CAG	p.E722Q		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	722	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCTGTTGGCAGAGGAGAATCG	0.587													0	0	0	0.870114	0	93	461										C	143565371	G	C	143565371	3	2	48	1	0	0	0	0	1	0	0	0	1298	943	33	1	2206	1	BAI1	8	143565371	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	22757578	143565371	2798651	64	13826										
ZNF250	58500	broad.mit.edu	37	chr8	146108082	146108082	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tggtcaacagagtttggactCagacagaagctttgctttgt	11	7	2	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr8:146108082C>G	uc003zeq.3	-	6	618	c.501G>C	c.(499-501)CTG>CTC	p.L167L	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Silent_p.L162L|ZNF250_uc010mgg.2_Silent_p.L162L	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		AGTTTGGACTCAGACAGAAGC	0.478													0	0	0	0.870114	0	110	371										G	146108082	C	G	146108082	2	3	48	1	0	0	0	0	0	0	0	1	17792	813	29	1		1	ZNF250	8	146108082	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	2542711	146108082	255940	65	13827										
TPM2	7169	broad.mit.edu	37	chr9	35685657	35685657	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgaccacctctcgctctcatCagccgccttctcggcctcct	6	20	4	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:35685657C>T	uc003zxq.2	-	3	600	c.361G>A	c.(361-363)GAT>AAT	p.D121N	TPM2_uc003zxr.2_Missense_Mutation_p.D121N|TPM2_uc003zxs.2_Missense_Mutation_p.D121N|TPM2_uc010mkz.2_Missense_Mutation_p.D121N|TPM2_uc011lpa.1_Missense_Mutation_p.D121N	NM_213674	NP_998839	P07951	TPM2_HUMAN	tropomyosin 2 (beta) isoform 2	121	By similarity.				muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			ovary(1)	1	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCGCTCTCATCAGCCGCCTTC	0.672													0	0	0	0.870114	0	84	112										T	35685657	C	T	35685657	3	4	48	1	0	0	0	0	1	0	0	0	16403	826	29	1	688	1	TPM2	9	35685657	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		35685657	105527774	66	13828										
ALG2	85365	broad.mit.edu	37	chr9	101984145	101984145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcaccgacggcttgggaaccGagtcccgttcccggccctgc	13	17	0	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:101984145G>A	uc004azf.2	-	1	102	c.32C>T	c.(31-33)TCG>TTG	p.S11L	ALG2_uc004azg.2_5'UTR|SEC61B_uc004azh.2_5'Flank	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	11					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				CTTGGGAACCGAGTCCCGTTC	0.726													0	0	0	0.557998	0	18	27										A	101984145	G	A	101984145	3	1	48	1	0	0	0	0	1	0	0	0	519	1059	37	1	1226	1	ALG2	9	101984145	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	66298488	101984145	39229286	67	13829										
SNX30	401548	broad.mit.edu	37	chr9	115600917	115600917	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttagaagagctgacagatgaCatgacagaagacttcctacc	9	9	0	8			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr9:115600917C>T	uc004bgj.3	+	6	1102	c.954C>T	c.(952-954)GAC>GAT	p.D318D	SNX30_uc004bgi.3_5'UTR	NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	318					cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						TGACAGATGACATGACAGAAG	0.483													0	0	0	0.827153	0	38	98										T	115600917	C	T	115600917	2	4	48	1	0	0	0	0	0	0	0	1	14900	477	17	2		2	SNX30	9	115600917	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	13616772	115600917	25612514	68	13830										
FAM171A1	221061	broad.mit.edu	37	chr10	15326047	15326047	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tggtgaagatctcgatgagcGcatctgctacgggctggtgg	16	8	2	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:15326047G>A	uc001iob.2	-	2	162	c.155C>T	c.(154-156)GCG>GTG	p.A52V		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	52	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						CTCGATGAGCGCATCTGCTAC	0.552													0	0	0	0.779181	0	33	45										A	15326047	G	A	15326047	3	1	48	1	0	0	0	0	1	0	0	0	5490	1087	38	2	2545	2	FAM171A1	10	15326047	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		15326047	120208700	69	13831										
SVIL	6840	broad.mit.edu	37	chr10	29752434	29752434	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcctcacctttgcagtactgGagcacagtctccatcgcact	8	15	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:29752434G>C	uc001iut.1	-	35	7017	c.6264C>G	c.(6262-6264)CTC>CTG	p.L2088L	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.L1002L|SVIL_uc001iuu.1_Silent_p.L1662L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2088	Gelsolin-like 5.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGCAGTACTGGAGCACAGTCT	0.617													0	0	0	0.435327	0	12	43										C	29752434	G	C	29752434	2	2	48	1	0	0	0	0	0	0	0	1	15418	1161	41	1		1	SVIL	10	29752434	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	14426387	29752434	105782313	70	13832										
CTNNA3	29119	broad.mit.edu	37	chr10	68381455	68381455	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	acttagttgtcatacctgtgGacacaaggtttccaaatgat	8	8	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:68381455G>A	uc009xpn.1	-	10	1492	c.1369C>T	c.(1369-1371)CCA>TCA	p.P457S	CTNNA3_uc001jmw.2_Missense_Mutation_p.P457S|CTNNA3_uc001jmx.3_Missense_Mutation_p.P457S	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	457					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CATACCTGTGGACACAAGGTT	0.279													0	0	0	0.38729	0	11	25										A	68381455	G	A	68381455	3	1	48	1	0	0	0	0	1	0	0	0	4014	1174	41	1	1354	1	CTNNA3	10	68381455	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	38629021	68381455	67153292	71	13833										
PBLD	64081	broad.mit.edu	37	chr10	70048339	70048339	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aggctctcctttaagggtaaGaataagccctttcaccttcc	7	12	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:70048339G>C	uc001jns.1	-	8	795	c.592C>G	c.(592-594)CTT>GTT	p.L198V	PBLD_uc001jnr.1_Missense_Mutation_p.L165V|PBLD_uc001jnt.1_Missense_Mutation_p.L198V|PBLD_uc001jnu.1_Missense_Mutation_p.L198V|PBLD_uc001jnv.1_3'UTR	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	198					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TTAAGGGTAAGAATAAGCCCT	0.468													0	0	0	0.870114	0	58	61										C	70048339	G	C	70048339	3	2	48	1	0	0	0	0	1	0	0	0	11489	942	33	1	375	1	PBLD	10	70048339	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	1666884	70048339	65486408	72	13834										
DNA2	1763	broad.mit.edu	37	chr10	70190242	70190242	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctaaggatttaatggactttGatctgcaaatttcttgctct	7	7	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:70190242G>A	uc001jof.2	-	14	2417	c.2417C>T	c.(2416-2418)TCA>TTA	p.S806L	DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	720					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						AATGGACTTTGATCTGCAAAT	0.348													0	0	0	0.27861	0	7	13										A	70190242	G	A	70190242	3	1	48	1	0	0	0	0	1	0	0	0	4596	1294	45	1	1055	1	DNA2	10	70190242	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	141903	70190242	65344505	73	13835										
TLL2	7093	broad.mit.edu	37	chr10	98155634	98155634	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggtctgagcagcactcacctCaaaagcttggaaggtaagtc	11	10	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:98155634C>G	uc001kml.1	-	12	1754	c.1528G>C	c.(1528-1530)GAG>CAG	p.E510Q	TLL2_uc009xvf.1_Missense_Mutation_p.E488Q	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	510	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCACTCACCTCAAAAGCTTGG	0.478											OREG0020398	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.859065	0	42	61										G	98155634	C	G	98155634	3	3	48	1	0	0	0	0	1	0	0	0	15943	835	29	1	1559	1	TLL2	10	98155634	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	27965392	98155634	37379113	74	13836										
SFRP5	6425	broad.mit.edu	37	chr10	99527601	99527601	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttctctatcttgatctccttGatgcgcattttgaccactgt	6	11	3	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:99527601G>T	uc001kor.3	-	3	790	c.624C>A	c.(622-624)ATC>ATA	p.I208I		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	208	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		TGATCTCCTTGATGCGCATTT	0.542													1	0	2.96211e-45	0.870114	3.45253e-45	107	228										T	99527601	G	T	99527601	2	4	48	1	0	0	0	0	0	0	0	1	14164	1280	45	3		3	SFRP5	10	99527601	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	1371967	99527601	36007146	75	13837										
SORCS1	114815	broad.mit.edu	37	chr10	108439408	108439408	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	acctgatgccactatgatgcTtggagctgtgtctttgctgg	12	9	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr10:108439408T>C	uc001kym.2	-	11	1653	c.1645A>G	c.(1645-1647)AGC>GGC	p.S549G	SORCS1_uc001kyl.2_Missense_Mutation_p.S549G|SORCS1_uc009xxs.2_Missense_Mutation_p.S549G|SORCS1_uc001kyn.1_Missense_Mutation_p.S549G|SORCS1_uc001kyo.2_Missense_Mutation_p.S549G	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	549	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACTATGATGCTTGGAGCTGTG	0.413													0	0	0	0.539581	0	15	17										C	108439408	T	C	108439408	3	2	48	1	0	0	0	0	1	0	0	0	14930	1609	56	5	2159	5	SORCS1	10	108439408	Missense_Mutation	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08	8911807	108439408	27095339	76	13838										
MRGPRE	116534	broad.mit.edu	37	chr11	3249613	3249613	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agggcgcacacacaggtggtCaggtggcgtgggcggcggca	20	10	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:3249613C>T	uc001lxq.3	-	2	724	c.414G>A	c.(412-414)CTG>CTA	p.L138L		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	138	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		CACAGGTGGTCAGGTGGCGTG	0.706													0	0	0	0.479597	0	13	18										T	3249613	C	T	3249613	2	4	48	1	0	0	0	0	0	0	0	1	9764	813	29	1		1	MRGPRE	11	3249613	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		3249613	131756903	77	13839										
OR51S1	119692	broad.mit.edu	37	chr11	4870194	4870194	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gtgtgggcatcagggcagtgAccaatccaatatcagacaca	11	10	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:4870194A>T	uc010qyo.1	-	1	245	c.245T>A	c.(244-246)GTC>GAC	p.V82D		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	82	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGGGCAGTGACCAATCCAAT	0.547													0	0	0	0.608945	0	21	65										T	4870194	A	T	4870194	3	4	48	1	0	0	0	0	1	0	0	0	11105	275	10	5	729	5	OR51S1	11	4870194	Missense_Mutation	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	1620581	4870194	130136322	78	13840										
IMMP1L	196294	broad.mit.edu	37	chr11	31455050	31455050	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttagtccatatggaataggtCcatagcacctggaatctgta	9	8	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:31455050C>A	uc001msy.1	-	6	585	c.389G>T	c.(388-390)GGA>GTA	p.G130V	IMMP1L_uc001msz.1_Missense_Mutation_p.G130V	NM_144981	NP_659418	Q96LU5	IMP1L_HUMAN	IMP1 inner mitochondrial membrane	130					proteolysis	mitochondrial inner membrane	serine-type peptidase activity				0	Lung SC(675;0.225)					TGGAATAGGTCCATAGCACCT	0.368													1	0	7.04047e-22	0.812448	7.79323e-22	36	56										A	31455050	C	A	31455050	3	1	48	1	0	0	0	0	1	0	0	0	7716	855	30	3	119	3	IMMP1L	11	31455050	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	26584856	31455050	103551466	79	13841										
POLA2	23649	broad.mit.edu	37	chr11	65046238	65046238	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aatacaactcacgaagtaacCgaggagaagtggttacctcc	9	10	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:65046238C>T	uc001odj.2	+	6	841	c.499C>T	c.(499-501)CGA>TGA	p.R167*	POLA2_uc009yqf.1_Nonsense_Mutation_p.R167*|POLA2_uc010rod.1_5'UTR|POLA2_uc001odk.2_5'Flank	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	167					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	ACGAAGTAACCGAGGAGAAGT	0.453													0	0	0	0.870114	0	66	169										T	65046238	C	T	65046238	4	4	48	1	0	0	0	0	0	1	0	0	12188	644	23	2	521	2	POLA2	11	65046238	Nonsense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	33591188	65046238	69960278	80	13842										
PCF11	51585	broad.mit.edu	37	chr11	82877720	82877720	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctggcaaagttccaagtctgCcaaaagatggaaatctggtt	10	8	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:82877720C>T	uc001ozx.3	+	5	2126	c.1781C>T	c.(1780-1782)GCC>GTC	p.A594V	PCF11_uc010rsu.1_Missense_Mutation_p.A594V	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	594					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TCCAAGTCTGCCAAAAGATGG	0.358													0	0	0	0.840704	0	43	78										T	82877720	C	T	82877720	3	4	48	1	0	0	0	0	1	0	0	0	11573	739	26	2	1799	2	PCF11	11	82877720	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	17831482	82877720	52128796	81	13843										
BACE1	23621	broad.mit.edu	37	chr11	117164662	117164662	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ccacaaagctgcagggagaaGaggttgggaacgtgggtctg	17	7	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:117164662G>C	uc001pqz.2	-	4	1091	c.630C>G	c.(628-630)CTC>CTG	p.L210L	BACE1_uc001pqw.2_Intron|BACE1_uc001pqx.2_Intron|BACE1_uc001pqy.2_Silent_p.L166L|BACE1_uc001pra.1_3'UTR|BACE1_uc010rxg.1_Intron|BACE1_uc010rxh.1_Silent_p.L110L|BACE1_uc009yzo.1_5'Flank	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	210	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		GCAGGGAGAAGAGGTTGGGAA	0.567													0	0	0	0.870114	0	57	73										C	117164662	G	C	117164662	2	2	48	1	0	0	0	0	0	0	0	1	1281	929	33	1		1	BACE1	11	117164662	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	34286942	117164662	17841854	82	13844										
TECTA	7007	broad.mit.edu	37	chr11	121028601	121028601	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cgcggcgctgccgctgtttcCgtcgcaacgtgattcagtgc	13	14	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr11:121028601C>T	uc010rzo.1	+	13	4357	c.4357C>T	c.(4357-4359)CGT>TGT	p.R1453C		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1453					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCGCTGTTTCCGTCGCAACGT	0.602													0	0	0	0.361761	0	9	177										T	121028601	C	T	121028601	3	4	48	1	0	0	0	0	1	0	0	0	15744	652	23	2	4407	2	TECTA	11	121028601	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	3863939	121028601	13977915	83	13845										
TEAD4	7004	broad.mit.edu	37	chr12	3128321	3128321	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aaacctatgctgtccagcctCcgctgcctctgccaggtggg	11	15	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:3128321C>T	uc010sej.1	+	8	842	c.565C>T	c.(565-567)CCG>TCG	p.P189S	TEAD4_uc010sek.1_Missense_Mutation_p.P146S|TEAD4_uc001qln.2_Missense_Mutation_p.P61S	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	190					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			TGTCCAGCCTCCGCTGCCTCT	0.682													0	0	0	0.870114	0	67	91										T	3128321	C	T	3128321	3	4	48	1	0	0	0	0	1	0	0	0	15738	855	30	1	590	1	TEAD4	12	3128321	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		3128321	130723574	84	13846										
TAS2R13	50838	broad.mit.edu	37	chr12	11061864	11061864	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tatgaattctgcaattattaCaagagtgaagatactcggca	8	6	1	4			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:11061864C>G	uc001qzg.1	-	1	298	c.34G>C	c.(34-36)GTA>CTA	p.V12L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron	NM_023920	NP_076409	Q9NYV9	T2R13_HUMAN	taste receptor, type 2, member 13	12	Helical; Name=1; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|skin(1)	2						GCAATTATTACAAGAGTGAAG	0.388													0	0	0	0.457914	0	12	27										G	11061864	C	G	11061864	3	3	48	1	0	0	0	0	1	0	0	0	15564	478	17	4	881	4	TAS2R13	12	11061864	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	7933543	11061864	122790031	85	13847										
ANP32D	23519	broad.mit.edu	37	chr12	48866717	48866717	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcagaaaagtgtccaaacctCatacatctaaatttaagtgg	7	8	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:48866717C>T	uc010slt.1	+	1	270	c.270C>T	c.(268-270)CTC>CTT	p.L90L		NM_012404	NP_036536	O95626	AN32D_HUMAN	acidic nuclear phosphoprotein 32D	90	LRR 4.									ovary(1)|central_nervous_system(1)	2						GTCCAAACCTCATACATCTAA	0.398													0	0	0	0.796494	0	35	53										T	48866717	C	T	48866717	2	4	48	1	0	0	0	0	0	0	0	1	708	813	29	1		1	ANP32D	12	48866717	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	37804853	48866717	84985178	86	13848										
MLL2	8085	broad.mit.edu	37	chr12	49425078	49425078	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ccagtgctgagttgcacattCtttgcccggagtagcttctg	11	11	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:49425078C>G	uc001rta.3	-	39	13410	c.13410G>C	c.(13408-13410)AAG>AAC	p.K4470N		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4470					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTTGCACATTCTTTGCCCGGA	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.870114	0	92	135										G	49425078	C	G	49425078	3	3	48	1	0	0	0	0	1	0	0	0	9621	912	32	1	3267	1	MLL2	12	49425078	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	558361	49425078	84426817	87	13849										
MLL2	8085	broad.mit.edu	37	chr12	49427906	49427906	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgtaaccagcttgagcttctCagcatcagcttctgggaact	9	11	3	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:49427906C>A	uc001rta.3	-	38	10684	c.10684G>T	c.(10684-10686)GAG>TAG	p.E3562*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3562	Potential.|Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTGAGCTTCTCAGCATCAGCT	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	3.4887e-51	0.870114	4.12088e-51	77	113										A	49427906	C	A	49427906	4	1	48	1	0	0	0	0	0	1	0	0	9621	835	29	3	5997	3	MLL2	12	49427906	Nonsense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	2828	49427906	84423989	88	13850										
HOXC11	3227	broad.mit.edu	37	chr12	54367330	54367330	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggccgacgagcttatgcaccGggagtgcctgcctccttcca	12	15	0	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:54367330G>A	uc001sem.2	+	1	421	c.305G>A	c.(304-306)CGG>CAG	p.R102Q		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	102					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTATGCACCGGGAGTGCCTG	0.672			T	NUP98	AML								0	0	0	0.870114	0	205	294										A	54367330	G	A	54367330	3	1	48	1	0	0	0	0	1	0	0	0	7310	1116	39	2	307	2	HOXC11	12	54367330	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	4939424	54367330	79484565	89	13851										
SMARCC2	6601	broad.mit.edu	37	chr12	56567574	56567574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gaggccccattggggttggtCgactctcagcatccacctgg	13	13	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:56567574C>T	uc001skb.2	-	17	1662	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	SMARCC2_uc001skd.2_Missense_Mutation_p.R519Q|SMARCC2_uc001ska.2_Missense_Mutation_p.R519Q|SMARCC2_uc001skc.2_Missense_Mutation_p.R519Q|SMARCC2_uc010sqf.1_Missense_Mutation_p.R408Q	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	519	SWIRM.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGGGTTGGTCGACTCTCAGC	0.577													0	0	0	0.870114	0	141	233										T	56567574	C	T	56567574	3	4	48	1	0	0	0	0	1	0	0	0	14776	884	31	1	2233	1	SMARCC2	12	56567574	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	2200244	56567574	77284321	90	13852										
SYT1	6857	broad.mit.edu	37	chr12	79611344	79611344	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gccctggcagccccgcctgtCaccactgtcgcgactgttct	10	18	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:79611344C>A	uc001sys.2	+	5	716	c.45C>A	c.(43-45)GTC>GTA	p.V15V	SYT1_uc001syt.2_Silent_p.V15V|SYT1_uc001syu.2_Silent_p.V15V|SYT1_uc001syv.2_Silent_p.V15V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	15	Vesicular (Potential).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CCCCGCCTGTCACCACTGTCG	0.517													1	0	3.08376e-08	0.654019	3.1926e-08	18	25										A	79611344	C	A	79611344	2	1	48	1	0	0	0	0	0	0	0	1	15462	813	29	3		3	SYT1	12	79611344	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	23043770	79611344	54240551	91	13853										
P2RX2	22953	broad.mit.edu	37	chr12	133196152	133196152	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	acgtggaggagtacgtgaagCcccccgaggtgcgggccgcc	17	13	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr12:133196152C>A	uc001ukj.1	+	2	301	c.301C>A	c.(301-303)CCC>ACC	p.P101T	P2RX2_uc001uki.1_Missense_Mutation_p.P101T|P2RX2_uc001ukk.1_Missense_Mutation_p.P101T|P2RX2_uc001ukl.1_Missense_Mutation_p.P101T|P2RX2_uc001ukm.1_Missense_Mutation_p.A78D|P2RX2_uc001ukn.1_Intron|P2RX2_uc009zyt.1_Missense_Mutation_p.P101T|P2RX2_uc001uko.1_Missense_Mutation_p.P101T	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	101	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		GTACGTGAAGCCCCCCGAGGT	0.577													1	0	3.05275e-18	0.864702	3.25626e-18	46	88										A	133196152	C	A	133196152	3	1	48	1	0	0	0	0	1	0	0	0	11340	739	26	4	307	4	P2RX2	12	133196152	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	53584808	133196152	655743	92	13854										
ZC3H13	23091	broad.mit.edu	37	chr13	46539484	46539484	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgccagaatttcatctagttCgtcatcactgattggctcgt	8	10	4	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr13:46539484C>T	uc010tfw.1	-	15	4408	c.4402G>A	c.(4402-4404)GAA>AAA	p.E1468K	ZC3H13_uc001vaq.2_Missense_Mutation_p.E53K|ZC3H13_uc001vas.1_Missense_Mutation_p.E1469K	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1468							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCATCTAGTTCGTCATCACTG	0.438													0	0	0	0.307466	0	9	124										T	46539484	C	T	46539484	3	4	48	1	0	0	0	0	1	0	0	0	17562	893	31	1	297	1	ZC3H13	13	46539484	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		46539484	68630394	93	13855										
FOS	2353	broad.mit.edu	37	chr14	75745827	75745827	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gctcgcctgtcaacgcgcagGtaaggctggcttcccgtcgc	13	15	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr14:75745827G>A	uc001xrn.2	+	1	346	c.141_splice	c.e1+1	p.Q47_splice	FOS_uc010tva.1_Splice_Site_p.Q47_splice|FOS_uc010asi.2_5'Flank|FOS_uc001xro.2_5'Flank	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene						cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CAACGCGCAGGTAAGGCTGGC	0.692													0	0	0	0.870114	0	41	62										A	75745827	G	A	75745827	5	1	48	1	0	0	0	0	0	0	1	0	5985	1275	44	2	144	2	FOS	14	75745827	Splice_Site	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		75745827	31603713	94	13856										
SETD3	84193	broad.mit.edu	37	chr14	99866554	99866554	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agttccccaaggtgaagattCtatcaatagcgctgtctccc	8	12	3	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr14:99866554C>T	uc001ygc.2	-	12	1390	c.1220G>A	c.(1219-1221)AGA>AAA	p.R407K		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	407					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				GGTGAAGATTCTATCAATAGC	0.333													0	0	0	0.870114	0	54	102										T	99866554	C	T	99866554	3	4	48	1	0	0	0	0	1	0	0	0	14132	913	32	1	572	1	SETD3	14	99866554	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	24120727	99866554	7482986	95	13857										
C15orf2	23742	broad.mit.edu	37	chr15	24921378	24921378	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggatccctcctcccagccgcAtgttcactctcctgctgcct	7	19	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:24921378A>C	uc001ywo.2	+	1	838	c.364A>C	c.(364-366)ATG>CTG	p.M122L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	122					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCCCAGCCGCATGTTCACTCT	0.647													0	0	0	0.870114	0	65	129										C	24921378	A	C	24921378	3	2	48	1	0	0	0	0	1	0	0	0	1784	217	8	5	366	5	C15orf2	15	24921378	Missense_Mutation	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08		24921378	77610014	96	13858										
DTWD1	56986	broad.mit.edu	37	chr15	49926748	49926748	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tttaggttgcactcatttttCctggacctcagtctatctca	6	11	4	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:49926748C>A	uc001zxq.2	+	5	701	c.424C>A	c.(424-426)CCT>ACT	p.P142T	DTWD1_uc001zxs.2_Missense_Mutation_p.P142T|DTWD1_uc001zxr.2_Missense_Mutation_p.P55T|DTWD1_uc001zxo.2_Missense_Mutation_p.P142T	NM_020234	NP_064619	Q8N5C7	DTWD1_HUMAN	DTW domain containing 1	142											0		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		ACTCATTTTTCCTGGACCTCA	0.308													1	0	8.16277e-20	0.827153	8.81379e-20	35	51										A	49926748	C	A	49926748	3	1	48	1	0	0	0	0	1	0	0	0	4791	855	30	3	434	3	DTWD1	15	49926748	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	25005370	49926748	52604644	97	13859										
SCG3	29106	broad.mit.edu	37	chr15	51975502	51975502	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aaaaggaaaaaattgagaaaGaaagacaatctataagaagc	8	3	1	4			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:51975502G>C	uc002abh.2	+	4	676	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	90					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		AATTGAGAAAGAAAGACAATC	0.358													0	0	0	0.870114	0	98	144										C	51975502	G	C	51975502	3	2	48	1	0	0	0	0	1	0	0	0	13892	943	33	1	282	1	SCG3	15	51975502	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	2048754	51975502	50555890	98	13860										
SLC24A1	9187	broad.mit.edu	37	chr15	65918024	65918025	+	Frame_Shift_Ins	INS	-	-	T													0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gggctctgctgtgttcaacaINSttctctttgtcattggcact							TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:65918024_65918025insT	uc010ujf.1	+	2	1893_1894	c.1606_1607insT	c.(1606-1608)ATTfs	p.I536fs	SLC24A1_uc010ujd.1_Frame_Shift_Ins_p.I536fs|SLC24A1_uc010uje.1_Frame_Shift_Ins_p.I536fs|SLC24A1_uc010ujg.1_Frame_Shift_Ins_p.I536fs|SLC24A1_uc010ujh.1_Frame_Shift_Ins_p.I536fs	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	536	Helical; (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TGTGTTCAACATTCTCTTTGTC	0.525																		69	150	---	---								T	65918025	-	T	65918024	7	5	48	1	0	1	1	0	0	0	0	0	14465	217	8	0		0	SLC24A1	15	65918024	Frame_Shift_Ins	INS	-	TCGA-DK-A1AE-01A-11D-A13W-08	13942522	65918024	36613368	99	13861										
HCN4	10021	broad.mit.edu	37	chr15	73624589	73624589	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	atcatgccgatgaggttcacGatgcgcaccacggcgctggc	13	13	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:73624589G>T	uc002avp.2	-	3	2248	c.1254C>A	c.(1252-1254)ATC>ATA	p.I418I		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	418	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TGAGGTTCACGATGCGCACCA	0.612													1	0	1.1794e-34	0.870114	1.3567e-34	70	96										T	73624589	G	T	73624589	2	4	48	1	0	0	0	0	0	0	0	1	6999	1048	37	3		3	HCN4	15	73624589	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	7706565	73624589	28906803	100	13862										
RPP25	54913	broad.mit.edu	37	chr15	75248520	75248520	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tccttggaaagtaggatggcGaggccgggcacgttcttaag	15	8	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:75248520G>A	uc002azj.1	-	1	1256	c.405C>T	c.(403-405)CTC>CTT	p.L135L		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	135					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GTAGGATGGCGAGGCCGGGCA	0.697													0	0	0	0.479597	0	15	19										A	75248520	G	A	75248520	2	1	48	1	0	0	0	0	0	0	0	1	13611	1045	37	1		1	RPP25	15	75248520	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	1623931	75248520	27282872	101	13863										
CHD2	1106	broad.mit.edu	37	chr15	93563313	93563313	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	acaatccaccatggggaagcGacaggcaccatcagtatgag	11	11	1	1	rs61752830		TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:93563313G>T	uc002bsp.2	+	38	5553	c.4978G>T	c.(4978-4980)GAC>TAC	p.D1660Y	CHD2_uc002bso.1_Missense_Mutation_p.D1660Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1660					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATGGGGAAGCGACAGGCACCA	0.512													1	0	1.1804e-14	0.667858	1.24401e-14	25	42										T	93563313	G	T	93563313	3	4	48	1	0	0	0	0	1	0	0	0	3325	1058	37	3	5128	3	CHD2	15	93563313	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	18314793	93563313	8968079	102	13864										
ADAMTS17	170691	broad.mit.edu	37	chr15	100673517	100673517	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ccacagtccagcacacattaGatgctgcaggacaagggaag	11	11	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr15:100673517G>A	uc002bvv.1	-	11	1556	c.1477C>T	c.(1477-1479)CTA>TTA	p.L493L	ADAMTS17_uc002bvx.1_Silent_p.L250L	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	493	Disintegrin.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		gcacacattagatgctGCAGG	0.244													0	0	0	0.248553	0	6	18										A	100673517	G	A	100673517	2	1	48	1	0	0	0	0	0	0	0	1	262	933	33	1		1	ADAMTS17	15	100673517	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	7110204	100673517	1857875	103	13865										
C16orf91	283951	broad.mit.edu	37	chr16	1476162	1476162	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ccccctgtagggacctgggaGcacccactgttgtgggagga	15	12	0	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:1476162G>T	uc010uvd.1	-	3	461	c.461C>A	c.(460-462)GCT>GAT	p.A154D		NM_001010878	NP_001010878	Q4G0I0	CSMT1_HUMAN	hypothetical protein LOC283951	127	Cytoplasmic (Potential).					integral to membrane					0						GGACCTGGGAGCACCCACTGT	0.637													1	0	2.59497e-14	0.834066	2.71854e-14	43	270										T	1476162	G	T	1476162	3	4	48	1	0	0	0	0	1	0	0	0	1844	971	34	4	619	4	C16orf91	16	1476162	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		1476162	88878591	104	13866										
CORO7	79585	broad.mit.edu	37	chr16	4411441	4411441	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttctgcagcgtgggcagtgcCgtgtcgggcaggcggccagg	19	11	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:4411441C>T	uc002cwh.3	-	17	1728	c.1608G>A	c.(1606-1608)ACG>ACA	p.T536T	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Silent_p.T536T|CORO7_uc002cwg.3_Silent_p.T316T|CORO7_uc010uxh.1_Silent_p.T518T|CORO7_uc010uxi.1_Silent_p.T451T|CORO7_uc002cwi.1_Silent_p.T316T|CORO7_uc010uxj.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	536						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TGGGCAGTGCCGTGTCGGGCA	0.687													0	0	0	0.804634	0	35	95										T	4411441	C	T	4411441	2	4	48	1	0	0	0	0	0	0	0	1	3759	639	23	2		2	CORO7	16	4411441	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	2935279	4411441	85943312	105	13867										
NDE1	54820	broad.mit.edu	37	chr16	15790770	15790770	+	Frame_Shift_Del	DEL	G	G	-													0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gggagaacccgcctgccccaGgcaagagacactcaccccca							TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:15790770delG	uc002ddt.1	+	7	1043	c.1000delG	c.(1000-1002)GGCfs	p.G334fs	NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	Error:Variant_position_missing_in_Q9NXR1_after_alignment					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						GCCTGCCCCAGGCAAGAGACA	0.552																		18	27	---	---								-	15790770	G	-	15790770	7	5	48	1	0	1	0	1	0	0	0	0	10243	1015	35	0		0	NDE1	16	15790770	Frame_Shift_Del	DEL	G	TCGA-DK-A1AE-01A-11D-A13W-08	11379329	15790770	74563983	106	13868										
SRCAP	10847	broad.mit.edu	37	chr16	30723437	30723437	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctgacattgctgcagcagctGaaagtctccagcccaagggt	11	12	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:30723437G>C	uc002dze.1	+	12	2159	c.1774G>C	c.(1774-1776)GAA>CAA	p.E592Q	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E449Q|SRCAP_uc010bzz.1_Missense_Mutation_p.E162Q	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	592					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGCAGCAGCTGAAAGTCTCCA	0.542													0	0	0	0.847076	0	42	85										C	30723437	G	C	30723437	3	2	48	1	0	0	0	0	1	0	0	0	15134	1291	45	1	1812	1	SRCAP	16	30723437	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	14932667	30723437	59631316	107	13869			2	52		3	3	1198	G		1.458732e-05
SRCAP	10847	broad.mit.edu	37	chr16	30724116	30724116	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cttactatggagcccagaaaGagaggaagctcaagcggcag	13	9	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:30724116G>A	uc002dze.1	+	14	2495	c.2110G>A	c.(2110-2112)GAG>AAG	p.E704K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E561K|SRCAP_uc010bzz.1_Missense_Mutation_p.E274K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	704	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGCCCAGAAAGAGAGGAAGCT	0.463													0	0	0	0.870114	0	77	125										A	30724116	G	A	30724116	3	1	48	1	0	0	0	0	1	0	0	0	15134	943	33	1	2156	1	SRCAP	16	30724116	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	679	30724116	59630637	108	13870			2	52		3	3	1198	G		1.458732e-05
SRCAP	10847	broad.mit.edu	37	chr16	30724634	30724634	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	actggcgctatctcattctgGatgaggcgcagaacatcaag	11	10	3	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:30724634G>C	uc002dze.1	+	15	2621	c.2236G>C	c.(2236-2238)GAT>CAT	p.D746H	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.D603H|SRCAP_uc010bzz.1_Missense_Mutation_p.D316H	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	746	Helicase ATP-binding.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TCTCATTCTGGATGAGGCGCA	0.527													0	0	0	0.870114	0	96	132										C	30724634	G	C	30724634	3	2	48	1	0	0	0	0	1	0	0	0	15134	1174	41	1	2286	1	SRCAP	16	30724634	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	518	30724634	59630119	109	13871			2	52		3	3	1198	G		1.458732e-05
ABCC12	94160	broad.mit.edu	37	chr16	48177903	48177903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cctttgccggtagcctttcaCcatcaccggcgtgagccagg	11	15	2	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:48177903C>T	uc002efc.1	-	2	539	c.193G>A	c.(193-195)GTG>ATG	p.V65M	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.V65M|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	65						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TAGCCTTTCACCATCACCGGC	0.547													0	0	0	0.788014	0	38	65										T	48177903	C	T	48177903	3	4	48	1	0	0	0	0	1	0	0	0	52	507	18	2	3998	2	ABCC12	16	48177903	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	17453269	48177903	42176850	110	13872										
CNOT1	23019	broad.mit.edu	37	chr16	58619315	58619316	+	Frame_Shift_Del	DEL	CT	CT	-													0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	catcatggttttagctacccCtccggaatcaggcaggatcc							TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:58619315_58619316delCT	uc002env.2	-	8	1025_1026	c.732_733delAG	c.(730-735)GGAGGGfs	p.G244fs	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Frame_Shift_Del_p.G244fs|CNOT1_uc002enx.2_Frame_Shift_Del_p.G244fs|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	244_245					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTAGCTACCCCTCCGGAATCAG	0.465																		62	169	---	---								-	58619316	CT	-	58619315	7	5	48	1	0	1	0	1	0	0	0	0	3617	681	24	0	6787	0	CNOT1	16	58619315	Frame_Shift_Del	DEL	CT	TCGA-DK-A1AE-01A-11D-A13W-08	10441412	58619315	31735438	111	13873										
CDH15	1013	broad.mit.edu	37	chr16	89261395	89261395	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctgtccagccagggcgatgaGgaccaggactacgactacct	12	13	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr16:89261395G>A	uc002fmt.2	+	14	2354	c.2277G>A	c.(2275-2277)GAG>GAA	p.E759E		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	759	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		AGGGCGATGAGGACCAGGACT	0.657													0	0	0	0.706142	0	28	32										A	89261395	G	A	89261395	2	1	48	1	0	0	0	0	0	0	0	1	3100	991	35	2		2	CDH15	16	89261395	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	30642080	89261395	1093358	112	13874										
ALOX12B	242	broad.mit.edu	37	chr17	7976982	7976982	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	agaccaccggtacctggcctGtgttgacagcagcgtgcttg	13	12	0	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:7976982G>T	uc002gjy.1	-	13	2009	c.1748C>A	c.(1747-1749)ACA>AAA	p.T583K		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	583	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						TACCTGGCCTGTGTTGACAGC	0.358										Multiple Myeloma(8;0.094)	OREG0024152	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.20262e-25	0.769981	2.45355e-25	33	63										T	7976982	G	T	7976982	3	4	48	1	0	0	0	0	1	0	0	0	537	1377	48	4	369	4	ALOX12B	17	7976982	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		7976982	73218228	113	13875										
MED24	9862	broad.mit.edu	37	chr17	38178227	38178227	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctggggctcgaaaggatgttGgcatcgtcctcattagagct	13	9	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:38178227G>T	uc002htt.2	-	23	2917	c.2604C>A	c.(2602-2604)GCC>GCA	p.A868A	MED24_uc010weq.1_5'Flank|MED24_uc002htr.2_5'UTR|MED24_uc010wer.1_Silent_p.A203A|MED24_uc010wes.1_Silent_p.A728A|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Silent_p.A893A|MED24_uc002htu.2_Silent_p.A855A|MED24_uc010cwn.2_Silent_p.A855A|MED24_uc010weu.1_Silent_p.A778A|MED24_uc010wev.1_Silent_p.A818A	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	868					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					AAAGGATGTTGGCATCGTCCT	0.587													1	0	8.79861e-51	0.870114	1.03237e-50	75	129										T	38178227	G	T	38178227	2	4	48	1	0	0	0	0	0	0	0	1	9442	1335	47	4		4	MED24	17	38178227	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	30201245	38178227	43016983	114	13876										
BRCA1	672	broad.mit.edu	37	chr17	41246211	41246211	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ctactgatttggagtgaactCtttcacttttacatattaaa	5	7	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:41246211C>G	uc002icq.2	-	10	1569	c.1337G>C	c.(1336-1338)AGA>ACA	p.R446T	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.R375T|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.R399T|BRCA1_uc002ict.2_Missense_Mutation_p.R446T|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.R446T|BRCA1_uc002ide.1_Missense_Mutation_p.R277T|BRCA1_uc010cyy.1_Missense_Mutation_p.R446T|BRCA1_uc010whs.1_Missense_Mutation_p.R446T|BRCA1_uc010cyz.2_Missense_Mutation_p.R399T|BRCA1_uc010cza.2_Missense_Mutation_p.R420T|BRCA1_uc010wht.1_Missense_Mutation_p.R150T	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	446					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGAGTGAACTCTTTCACTTTT	0.378			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	0.864702	0	47	70										G	41246211	C	G	41246211	3	3	48	1	0	0	0	0	1	0	0	0	1498	913	32	1	4380	1	BRCA1	17	41246211	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	3067984	41246211	39948999	115	13877										
SCN4A	6329	broad.mit.edu	37	chr17	62020234	62020234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gtcaaagatgttccagccaaCggtgaagtagtactggcgca	12	9	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:62020234C>T	uc002jds.1	-	23	4317	c.4240G>A	c.(4240-4242)GTT>ATT	p.V1414I		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1414	Helical; Name=S3 of repeat IV; (Potential).|IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TTCCAGCCAACGGTGAAGTAG	0.572													0	0	0	0.870114	0	63	190										T	62020234	C	T	62020234	3	4	48	1	0	0	0	0	1	0	0	0	13920	536	19	2	1278	2	SCN4A	17	62020234	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	20774023	62020234	19174976	116	13878										
GRIN2C	2905	broad.mit.edu	37	chr17	72843023	72843023	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gccgttgggcaccgtgccgaAgcggaaaggtgggtactgat	17	9	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:72843023A>C	uc002jlt.1	-	10	2194	c.2038T>G	c.(2038-2040)TTC>GTC	p.F680V	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Missense_Mutation_p.F680V	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	680	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	ACCGTGCCGAAGCGGAAAGGT	0.612													0	0	0	0.870114	0	104	260										C	72843023	A	C	72843023	3	2	48	1	0	0	0	0	1	0	0	0	6781	72	3	5	1679	5	GRIN2C	17	72843023	Missense_Mutation	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	10822789	72843023	8352187	117	13879										
GGA3	23163	broad.mit.edu	37	chr17	73235616	73235616	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gctggggtggtggtggggatGagaggggaggtagtgggttt	25	1	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:73235616G>A	uc002jni.1	-	14	1629	c.1620C>T	c.(1618-1620)CTC>CTT	p.L540L	GGA3_uc002jnj.1_Silent_p.L507L|GGA3_uc010wrw.1_Silent_p.L418L|GGA3_uc002jnk.1_Silent_p.L468L|GGA3_uc010wrx.1_Silent_p.L418L|GGA3_uc010wry.1_Silent_p.L468L	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	540	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGGTGGGGATGAGAGGGGAGG	0.667											OREG0024729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.27861	0	8	24										A	73235616	G	A	73235616	2	1	48	1	0	0	0	0	0	0	0	1	6354	1277	45	1		1	GGA3	17	73235616	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	392593	73235616	7959594	118	13880										
SLC25A19	60386	broad.mit.edu	37	chr17	73269536	73269536	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggggtccttcctgcactcagCgctggctggctgtcctgttc	13	14	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:73269536C>T	uc002jns.3	-	6	1869	c.959G>A	c.(958-960)CGC>CAC	p.R320H	SLC25A19_uc010dge.2_Missense_Mutation_p.R263H|SLC25A19_uc002jnv.3_Missense_Mutation_p.R320H|SLC25A19_uc002jnu.3_Missense_Mutation_p.R320H|SLC25A19_uc002jnw.3_Missense_Mutation_p.R320H|SLC25A19_uc002jnt.3_Missense_Mutation_p.R320H	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	320						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			CTGCACTCAGCGCTGGCTGGC	0.567													0	0	0	0.870114	0	46	185										T	73269536	C	T	73269536	3	4	48	1	0	0	0	0	1	0	0	0	14481	768	27	2	7	2	SLC25A19	17	73269536	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	33920	73269536	7925674	119	13881										
GAA	2548	broad.mit.edu	37	chr17	78079575	78079575	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	atccagctaacaggcgctacGaggtgcccttggagaccccg	12	14	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr17:78079575G>T	uc002jxo.2	+	4	756	c.574G>T	c.(574-576)GAG>TAG	p.E192*	GAA_uc002jxp.2_Nonsense_Mutation_p.E192*|GAA_uc002jxq.2_Nonsense_Mutation_p.E192*	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	192					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	CAGGCGCTACGAGGTGCCCTT	0.602													1	0	7.47603e-22	0.870114	8.22363e-22	49	193										T	78079575	G	T	78079575	4	4	48	1	0	0	0	0	0	1	0	0	6147	1059	37	3	580	3	GAA	17	78079575	Nonsense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	4810039	78079575	3115635	120	13882										
ZADH2	284273	broad.mit.edu	37	chr18	72913894	72913894	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cagacttttcatcagaagagCaggttccaattacatggcac	8	10	2	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr18:72913894C>A	uc002llx.2	-	2	879	c.611G>T	c.(610-612)TGC>TTC	p.C204F	ZADH2_uc010dqv.2_Missense_Mutation_p.C81F	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	204						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		ATCAGAAGAGCAGGTTCCAAT	0.468													1	0	1.47391e-114	0.870114	1.75275e-114	267	687										A	72913894	C	A	72913894	3	1	48	1	0	0	0	0	1	0	0	0	17508	710	25	4	526	4	ZADH2	18	72913894	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		72913894	5163354	121	13883										
PLIN5	440503	broad.mit.edu	37	chr19	4523684	4523684	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgctctgcctcccaggctctCtgctgggccggccagtccag	12	17	2	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:4523684C>T	uc002mas.2	-	8	1301	c.1248G>A	c.(1246-1248)CAG>CAA	p.Q416Q		NM_001013706	NP_001013728	Q00G26	PLIN5_HUMAN	lipid storage droplet protein 5	416						lipid particle					0						CCCAGGCTCTCTGCTGGGCCG	0.711											OREG0025168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.870114	0	129	177										T	4523684	C	T	4523684	2	4	48	1	0	0	0	0	0	0	0	1	12093	912	32	1		1	PLIN5	19	4523684	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08		4523684	54605299	122	13884										
DOCK6	57572	broad.mit.edu	37	chr19	11348960	11348960	+	Frame_Shift_Del	DEL	G	G	-													0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tgctgaagttgaggctgtgcGggtacacgtacagcaggttc					rs12609039	by1000genomes	TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:11348960delG	uc002mqs.3	-	15	1705	c.1664delC	c.(1663-1665)CCGfs	p.P555fs	DOCK6_uc010xlq.1_5'Flank|LOC55908_uc010dxw.2_Intron|LOC55908_uc010dxx.2_Intron	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	555	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GAGGCTGTGCGGGTACACGTA	0.647																		22	48	---	---								-	11348960	G	-	11348960	7	5	48	1	0	1	0	1	0	0	0	0	4691	1116	39	0	4615	0	DOCK6	19	11348960	Frame_Shift_Del	DEL	G	TCGA-DK-A1AE-01A-11D-A13W-08	6825276	11348960	47780023	123	13885										
LOC55908	55908	broad.mit.edu	37	chr19	11350372	11350372	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aatggtgacccggcctgcctCagcggcccccatgggcggcc	14	17	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:11350372C>T	uc010dxx.2	+	2	220	c.218C>T	c.(217-219)TCA>TTA	p.S73L	DOCK6_uc010xlq.1_5'Flank|DOCK6_uc002mqs.3_Intron|LOC55908_uc010dxw.2_Intron	NM_018687	NP_061157	Q6UXH0	TD26_HUMAN	hepatocellular carcinoma-associated gene TD26	20						extracellular region					0						CGGCCTGCCTCAGCGGCCCCC	0.642													0	0	0	0.796494	0	37	53										T	11350372	C	T	11350372	3	4	48	1	0	0	0	0	1	0	0	0	8881	838	29	1	61	1	LOC55908	19	11350372	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	1412	11350372	47778611	124	13886										
MLL4	9757	broad.mit.edu	37	chr19	36223287	36223287	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cagggtgccccctcctacctCagtcgtcacagccctcacac	7	20	3	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:36223287C>T	uc010eei.2	+	29	5837	c.5837C>T	c.(5836-5838)TCA>TTA	p.S1946L		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1946					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCCTACCTCAGTCGTCACA	0.677													0	0	0	0.693898	0	24	29										T	36223287	C	T	36223287	3	4	48	1	0	0	0	0	1	0	0	0	9623	838	29	1	5947	1	MLL4	19	36223287	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	24872915	36223287	22905696	125	13887										
ERF	2077	broad.mit.edu	37	chr19	42752674	42752674	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcatgctggaggtcagagctCacccgccttggggtgagggg	18	10	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:42752674C>A	uc002ote.3	-	4	1748	c.1590G>T	c.(1588-1590)GTG>GTT	p.V530V	ERF_uc002otd.3_Silent_p.V261V	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	530					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				GGTCAGAGCTCACCCGCCTTG	0.711													1	0	2.68985e-26	0.870114	3.05428e-26	48	72										A	42752674	C	A	42752674	2	1	48	1	0	0	0	0	0	0	0	1	5221	813	29	3		3	ERF	19	42752674	Silent	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	6529387	42752674	16376309	126	13888										
ZNF234	10780	broad.mit.edu	37	chr19	44662014	44662014	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tcaagtctccaacttcatcaGagtgtccacacaggagagaa	8	11	4	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:44662014G>C	uc002oym.2	+	6	2152	c.1845G>C	c.(1843-1845)CAG>CAC	p.Q615H	ZNF234_uc002oyl.3_Missense_Mutation_p.Q615H	NM_006630	NP_006621	Q14588	ZN234_HUMAN	zinc finger protein 234	615	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AACTTCATCAGAGTGTCCACA	0.473													0	0	0	0.870114	0	55	81										C	44662014	G	C	44662014	3	2	48	1	0	0	0	0	1	0	0	0	17784	933	33	1	1859	1	ZNF234	19	44662014	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	1909340	44662014	14466969	127	13889										
PNMAL1	55228	broad.mit.edu	37	chr19	46973800	46973800	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ccggctgcggatctcggcatCcatgcagaagatgatctgca	12	12	2	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:46973800C>G	uc002peq.3	-	2	799	c.493G>C	c.(493-495)GAT>CAT	p.D165H	PNMAL1_uc002per.3_Missense_Mutation_p.D165H	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	165											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ATCTCGGCATCCATGCAGAAG	0.428													0	0	0	0.870114	0	121	175										G	46973800	C	G	46973800	3	3	48	1	0	0	0	0	1	0	0	0	12157	855	30	1	856	1	PNMAL1	19	46973800	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	2311786	46973800	12155183	128	13890										
FAM71E1	112703	broad.mit.edu	37	chr19	50978631	50978631	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggcagggccggccagaagcaAtaggtccgggagctccaggg	18	11	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:50978631A>G	uc002psh.2	-	3	848	c.490T>C	c.(490-492)TTG>CTG	p.L164L	FAM71E1_uc002psg.2_Silent_p.L148L|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	164										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GCCAGAAGCAATAGGTCCGGG	0.647													0	0	0	0.457914	0	14	36										G	50978631	A	G	50978631	2	3	48	1	0	0	0	0	0	0	0	1	5611	98	4	5		5	FAM71E1	19	50978631	Silent	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	4004831	50978631	8150352	129	13891										
MBOAT7	79143	broad.mit.edu	37	chr19	54677813	54677813	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cgccggctggggctgcccccAcctaaagccagccccagccc	11	21	0	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr19:54677813A>C	uc002qdq.2	-	9	1610	c.1344T>G	c.(1342-1344)GGT>GGG	p.G448G	TMC4_uc010erf.2_5'Flank|TMC4_uc002qdo.2_5'Flank|MBOAT7_uc010erg.2_Silent_p.G132G|MBOAT7_uc010yem.1_Silent_p.G430G|MBOAT7_uc002qdr.2_Silent_p.G448G|MBOAT7_uc002qds.2_Silent_p.G375G|MBOAT7_uc010yen.1_Silent_p.G375G	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	448	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGCTGCCCCCACCTAAAGCCA	0.662													0	0	0	0.479597	0	10	105										C	54677813	A	C	54677813	2	2	48	1	0	0	0	0	0	0	0	1	9358	146	6	5		5	MBOAT7	19	54677813	Silent	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	3699182	54677813	4451170	130	13892										
BAGE2	85319	broad.mit.edu	37	chr21	11058303	11058303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	catttgatagtggctccaaaGtgcttacaaaatgcacatcg	8	9	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr21:11058303G>A	uc002yit.1	-	3	345	c.137C>T	c.(136-138)ACT>ATT	p.T46I	BAGE_uc002yiw.1_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGCTCCAAAGTGCTTACAAA	0.388													0	0	0	0.435327	0	10	268										A	11058303	G	A	11058303	3	1	48	1	0	0	0	0	1	0	0	0	1292	1029	36	2	200	2	BAGE2	21	11058303	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		11058303	37071592	131	13893										
RNF160	26046	broad.mit.edu	37	chr21	30365173	30365173	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	cactcagaccccggttgacaCgtccgggacacaacttccgg	10	16	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr21:30365173C>A	uc002ymr.2	-	1	105	c.92G>T	c.(91-93)CGT>CTT	p.R31L		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	Error:Variant_position_missing_in_O94822_after_alignment							ligase activity|zinc ion binding				0						CCGGTTGACACGTCCGGGACA	0.622													1	0	0.000229342	0.608945	0.000234675	22	44										A	30365173	C	A	30365173	3	1	48	1	0	0	0	0	1	0	0	0	13455	536	19	4	5466	4	RNF160	21	30365173	Missense_Mutation	SNP	C	TCGA-DK-A1AE-01A-11D-A13W-08	19306870	30365173	17764722	132	13894										
TMEM50B	757	broad.mit.edu	37	chr21	34823156	34823156	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gctcttcggttcttccaaatTtgtagatcagagtgctagaa	9	8	3	3			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr21:34823156T>C	uc002yrt.1	-	7	624	c.446A>G	c.(445-447)AAA>AGA	p.K149R	TMEM50B_uc002yrs.1_RNA|TMEM50B_uc010gmb.1_RNA	NM_006134	NP_006125	P56557	TM50B_HUMAN	transmembrane protein 50B	149						endoplasmic reticulum|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TCTTCCAAATTTGTAGATCAG	0.348													0	0	0	0.840704	0	38	45										C	34823156	T	C	34823156	3	2	48	1	0	0	0	0	1	0	0	0	16173	1841	64	5	34	5	TMEM50B	21	34823156	Missense_Mutation	SNP	T	TCGA-DK-A1AE-01A-11D-A13W-08	4457983	34823156	13306739	133	13895										
CECR6	27439	broad.mit.edu	37	chr22	17600373	17600373	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gcccagctgggagcctccctGaggtggtggcggaggtggtg	20	10	0	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:17600373G>A	uc002zmb.2	-	1	1841	c.1645C>T	c.(1645-1647)CAG>TAG	p.Q549*	CECR6_uc002zma.2_Nonsense_Mutation_p.Q194*|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	549											0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		GAGCCTCCCTGAGGTGGTGGC	0.687													0	0	0	0.335167	0	8	20										A	17600373	G	A	17600373	4	1	48	1	0	0	0	0	0	1	0	0	3208	1299	45	1	95	1	CECR6	22	17600373	Nonsense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		17600373	33704193	134	13896										
GNAZ	2781	broad.mit.edu	37	chr22	23438310	23438310	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ggcacaggcctgcttcagccGctccagcgagtaccacctgg	12	16	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:23438310G>A	uc002zwu.1	+	2	965	c.428G>A	c.(427-429)CGC>CAC	p.R143H	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	143						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		TGCTTCAGCCGCTCCAGCGAG	0.657													0	0	0	0.361761	0	7	140										A	23438310	G	A	23438310	3	1	48	1	0	0	0	0	1	0	0	0	6514	1087	38	2	430	2	GNAZ	22	23438310	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	5837937	23438310	27866256	135	13897										
MTP18	51537	broad.mit.edu	37	chr22	30822725	30822725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gctatgccaatgaggtgggcGaggctttccgctctcttgtg	14	10	1	1			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:30822725G>A	uc003ahw.1	+	2	236	c.88G>A	c.(88-90)GAG>AAG	p.E30K	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Missense_Mutation_p.E192K|MTP18_uc010gvy.1_Intron|MTP18_uc003ahx.1_Missense_Mutation_p.E30K	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	30					apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						TGAGGTGGGCGAGGCTTTCCG	0.502											OREG0026460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.870114	0	37	73										A	30822725	G	A	30822725	3	1	48	1	0	0	0	0	1	0	0	0	9955	1059	37	1	94	1	MTP18	22	30822725	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	7384415	30822725	20481841	136	13898										
HMGXB4	10042	broad.mit.edu	37	chr22	35684398	35684398	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	gacaccgtctgcaggaaactGaggtgaatacaactatcagc	10	10	2	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:35684398G>A	uc003anl.2	+	9	1810	c.1636G>A	c.(1636-1638)GAG>AAG	p.E546K	HMGXB4_uc003ank.2_Missense_Mutation_p.E437K	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	546					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						GCAGGAAACTGAGGTGAATAC	0.348													0	0	0	0.681144	0	25	53										A	35684398	G	A	35684398	3	1	48	1	0	0	0	0	1	0	0	0	7239	1291	45	1	1666	1	HMGXB4	22	35684398	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	4861673	35684398	15620168	137	13899										
C22orf9	23313	broad.mit.edu	37	chr22	45601515	45601515	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	tcgtgccagggctcacctgaGatttcttcttatggatgtga	11	9	3	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chr22:45601515G>T	uc003bfx.1	-	4	476	c.410C>A	c.(409-411)TCT>TAT	p.S137Y	C22orf9_uc010gzw.1_5'UTR|C22orf9_uc003bfv.1_Missense_Mutation_p.S146Y|C22orf9_uc003bfw.1_Missense_Mutation_p.S142Y|C22orf9_uc010gzx.2_Missense_Mutation_p.S119Y	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	137							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		GCTCACCTGAGATTTCTTCTT	0.597													1	0	7.63091e-17	0.834066	8.09061e-17	41	81										T	45601515	G	T	45601515	3	4	48	1	0	0	0	0	1	0	0	0	2151	942	33	3	832	3	C22orf9	22	45601515	Missense_Mutation	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08	9917117	45601515	5703051	138	13900										
AR	367	broad.mit.edu	37	chrX	66765006	66765006	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	aggatggaagtgcagttaggGctgggaagggtctaccctcg	17	7	1	0			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chrX:66765006G>A	uc004dwu.1	+	1	1133	c.18G>A	c.(16-18)GGG>GGA	p.G6G	AR_uc011mpd.1_Silent_p.G6G|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Silent_p.G6G	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	6	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TGCAGTTAGGGCTGGGAAGGG	0.577									Androgen_Insensitivity_Syndrome				0	0	0	0.827153	0	37	8										A	66765006	G	A	66765006	2	1	48	1	0	0	0	0	0	0	0	1	836	1190	42	2		2	AR	23	66765006	Silent	SNP	G	TCGA-DK-A1AE-01A-11D-A13W-08		66765006	88505554	139	13901										
KIAA1210	57481	broad.mit.edu	37	chrX	118220587	118220587	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	50	1.22189898765036e-17	3.74528894472362	5.16849874371859	3.03368404522613	0.571454681522549	0.7111952018206	37	ttgcttatctgcaacgtaagAtattttggtgaggttccctg	10	7	1	2			TCGA-DK-A1AE-01A-11D-A13W-08	TCGA-DK-A1AE-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	abd2d959-d5ed-4eb3-9759-67eb1aa23325	3ddb747a-54ce-430d-9b95-efb61ff3d1bf	g.chrX:118220587A>G	uc004era.3	-	11	4606	c.4606T>C	c.(4606-4608)TCT>CCT	p.S1536P		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1536										ovary(4)|skin(1)	5						GCAACGTAAGATATTTTGGTG	0.512													0	0	0	0.870114	0	53	15										G	118220587	A	G	118220587	3	3	48	1	0	0	0	0	1	0	0	0	8214	333	12	5	539	5	KIAA1210	23	118220587	Missense_Mutation	SNP	A	TCGA-DK-A1AE-01A-11D-A13W-08	51455581	118220587	37049973	140	13902										
PRAMEF2	65122	broad.mit.edu	37	chr1	12921316	12921316	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tactcccaactcagtgccatCctgcctggcctgagctgctg	9	16	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:12921316C>G	uc001aum.1	+	4	1194	c.1107C>G	c.(1105-1107)ATC>ATG	p.I369M		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	369	LRR 2.										0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGTGCCATCCTGCCTGGCC	0.562													0	0	0	0.00308	0	7	187										G	12921316	C	G	12921316	3	3	49	1	0	0	0	0	1	0	0	0	12435	845	30	1	1117	1	PRAMEF2	1	12921316	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		12921316	236329305	1	13903										
KIAA0754	643314	broad.mit.edu	37	chr1	39878410	39878410	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gtaatactgaaccagttttaGaggaatggatacccgtcctc	9	9	0	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:39878410G>C	uc009vvt.1	+	1	3235	c.2473G>C	c.(2473-2475)GAG>CAG	p.E825Q	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	689											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACCAGTTTTAGAGGAATGGAT	0.493													0	0	0	0.009096	0	3	24										C	39878410	G	C	39878410	3	2	49	1	0	0	0	0	1	0	0	0	8192	943	33	1	2475	1	KIAA0754	1	39878410	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	26957094	39878410	209372211	2	13904										
CTPS	1503	broad.mit.edu	37	chr1	41471729	41471729	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttttggtatttcagatgccaAttctacagagtttgacccta	7	8	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:41471729A>G	uc001cgk.3	+	13	1767	c.1259A>G	c.(1258-1260)AAT>AGT	p.N420S	CTPS_uc010ojo.1_Missense_Mutation_p.N189S|CTPS_uc001cgl.3_Missense_Mutation_p.N420S|CTPS_uc010ojq.1_Missense_Mutation_p.N264S|CTPS_uc009vwe.2_Missense_Mutation_p.N140S	NM_001905	NP_001896	P17812	PYRG1_HUMAN	CTP synthase	420	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)			L-Glutamine(DB00130)	TCAGATGCCAATTCTACAGAG	0.408													0	0	0	0.004672	0	3	119										G	41471729	A	G	41471729	3	3	49	1	0	0	0	0	1	0	0	0	4022	101	4	5	1305	5	CTPS	1	41471729	Missense_Mutation	SNP	A	TCGA-DK-A1AF-01A-11D-A13W-08	1593319	41471729	207778892	3	13905										
C8B	732	broad.mit.edu	37	chr1	57409489	57409489	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acaggcatggacgttgttaaGagtataatctgaagaaaaca	10	5	1	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:57409489G>C	uc001cyp.2	-	8	1181	c.1114C>G	c.(1114-1116)CTT>GTT	p.L372V	C8B_uc010oon.1_Missense_Mutation_p.L310V|C8B_uc010ooo.1_Missense_Mutation_p.L320V	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	372	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						ACGTTGTTAAGAGTATAATCT	0.443													0	0	0	0.021553	0	6	112										C	57409489	G	C	57409489	3	2	49	1	0	0	0	0	1	0	0	0	2417	942	33	1	681	1	C8B	1	57409489	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	15937760	57409489	191841132	4	13906										
LRRC7	57554	broad.mit.edu	37	chr1	70504020	70504020	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tctcttaagttcgaaatctaGaagcacatcttcgcatggac	7	10	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:70504020G>A	uc001dep.2	+	19	2429	c.2399G>A	c.(2398-2400)AGA>AAA	p.R800K	LRRC7_uc009wbg.2_Missense_Mutation_p.R84K|LRRC7_uc001deq.2_Missense_Mutation_p.R41K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	800						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCGAAATCTAGAAGCACATCT	0.488													0	0	0	0.010729	0	11	181										A	70504020	G	A	70504020	3	1	49	1	0	0	0	0	1	0	0	0	9020	942	33	1	2473	1	LRRC7	1	70504020	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	13094531	70504020	178746601	5	13907										
PSMD4	5710	broad.mit.edu	37	chr1	151238867	151238867	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgacctaagcagtatgactGaggaagagcagattgcttat	11	7	0	5			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:151238867G>C	uc001exl.2	+	8	909	c.847G>C	c.(847-849)GAG>CAG	p.E283Q	PSMD4_uc001exn.2_Missense_Mutation_p.E286Q	NM_002810	NP_002801	P55036	PSMD4_HUMAN	proteasome 26S non-ATPase subunit 4	283	UIM 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding|zinc ion binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGTATGACTGAGGAAGAGCA	0.552													0	0	0	0.013537	0	12	99										C	151238867	G	C	151238867	3	2	49	1	0	0	0	0	1	0	0	0	12700	1291	45	1	877	1	PSMD4	1	151238867	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	80734847	151238867	98011754	6	13908										
FLG	2312	broad.mit.edu	37	chr1	152275618	152275618	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	agtctgactgtacaggtgaaGactgtacatgactggctgta	12	7	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:152275618G>C	uc001ezu.1	-	3	11780	c.11744C>G	c.(11743-11745)TCT>TGT	p.S3915C		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3915	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TACAGGTGAAGACTGTACATG	0.498									Ichthyosis				0	0	0	0.001984	0	5	101										C	152275618	G	C	152275618	3	2	49	1	0	0	0	0	1	0	0	0	5922	942	33	1	445	1	FLG	1	152275618	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	1036751	152275618	96975003	7	13909										
IQGAP3	128239	broad.mit.edu	37	chr1	156507074	156507074	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cgtctctggacctcggggtgGctcaaggcctgctccggggt	16	13	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:156507074G>A	uc001fpf.2	-	27	3396	c.3321C>T	c.(3319-3321)AGC>AGT	p.S1107S		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1107	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTCGGGGTGGCTCAAGGCCT	0.562													0	0	0	0.004672	0	3	36										A	156507074	G	A	156507074	2	1	49	1	0	0	0	0	0	0	0	1	7816	1194	42	2		2	IQGAP3	1	156507074	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	4231456	156507074	92743547	8	13910										
PBX1	5087	broad.mit.edu	37	chr1	164761814	164761814	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acatgctgttagcggaaggcGtggcggggcctgagaagggc	19	8	0	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:164761814G>A	uc001gct.2	+	3	607	c.349G>A	c.(349-351)GTG>ATG	p.V117M	PBX1_uc010pku.1_Missense_Mutation_p.V117M|PBX1_uc010pkv.1_Missense_Mutation_p.V34M|PBX1_uc001gcs.2_Missense_Mutation_p.V117M|PBX1_uc010pkw.1_Missense_Mutation_p.V7M	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	117					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						AGCGGAAGGCGTGGCGGGGCC	0.493			T	TCF3|EWSR1	pre B-ALL|myoepithelioma								0	0	0	0.004672	0	3	18										A	164761814	G	A	164761814	3	1	49	1	0	0	0	0	1	0	0	0	11492	1145	40	2	359	2	PBX1	1	164761814	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	8254740	164761814	84488807	9	13911										
PM20D1	148811	broad.mit.edu	37	chr1	205819093	205819093	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aactgagaagggattcgcgaCgccctttgatgctccccgct	11	13	0	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:205819093C>T	uc001hdj.2	-	1	153	c.108G>A	c.(106-108)GCG>GCA	p.A36A	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	36						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GGATTCGCGACGCCCTTTGAT	0.592													0	0	0	0.014758	0	5	58										T	205819093	C	T	205819093	2	4	49	1	0	0	0	0	0	0	0	1	12128	523	19	2		2	PM20D1	1	205819093	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	41057279	205819093	43431528	10	13912										
LAMB3	3914	broad.mit.edu	37	chr1	209789846	209789846	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gtccatcatctccatggtctCcccaaacagctcctctgcct	5	18	4	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:209789846C>T	uc001hhg.2	-	21	3742	c.3352G>A	c.(3352-3354)GAG>AAG	p.E1118K	LAMB3_uc009xco.2_Missense_Mutation_p.E1118K|LAMB3_uc001hhh.2_Missense_Mutation_p.E1118K	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1118	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TCCATGGTCTCCCCAAACAGC	0.552													0	0	0	0.013537	0	9	183										T	209789846	C	T	209789846	3	4	49	1	0	0	0	0	1	0	0	0	8612	864	30	1	174	1	LAMB3	1	209789846	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	3970753	209789846	39460775	11	13913										
KCNK2	3776	broad.mit.edu	37	chr1	215256745	215256745	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cctcatgcttcccagcgcctCgcgggagagacccggctata	11	16	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr1:215256745C>T	uc001hkq.2	+	1	186	c.17C>T	c.(16-18)TCG>TTG	p.S6L	KCNK2_uc001hko.2_Intron|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_Intron|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Intron	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	6	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCCAGCGCCTCGCGGGAGAGA	0.547													0	0	0	0.008291	0	9	79										T	215256745	C	T	215256745	3	4	49	1	0	0	0	0	1	0	0	0	8066	893	31	1	62	1	KCNK2	1	215256745	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	5466899	215256745	33993876	12	13914										
UGP2	7360	broad.mit.edu	37	chr2	64114722	64114722	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	caggatctctgacaatgagtGaaaagcgggaatttcctaca	10	8	1	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:64114722G>A	uc002scm.2	+	8	1564	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	UGP2_uc002scl.2_Missense_Mutation_p.E409K|UGP2_uc010ypx.1_Missense_Mutation_p.E429K	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	420					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						GACAATGAGTGAAAAGCGGGA	0.403													0	0	0	0.010729	0	12	195										A	64114722	G	A	64114722	3	1	49	1	0	0	0	0	1	0	0	0	16940	1291	45	1	1288	1	UGP2	2	64114722	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		64114722	179084651	13	13915										
VPS54	51542	broad.mit.edu	37	chr2	64208891	64208891	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aatccccatgtttttgtgaaGaagtcagattctctttttgc	7	8	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:64208891G>A	uc002scq.2	-	3	430	c.267C>T	c.(265-267)TTC>TTT	p.F89F	VPS54_uc002scp.2_Silent_p.F77F	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	89					protein transport|retrograde transport, endosome to Golgi						0						TTTTTGTGAAGAAGTCAGATT	0.388													0	0	0	0.012319	0	22	269										A	64208891	G	A	64208891	2	1	49	1	0	0	0	0	0	0	0	1	17213	933	33	1		1	VPS54	2	64208891	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	94169	64208891	178990482	14	13916										
CCDC142	84865	broad.mit.edu	37	chr2	74709847	74709847	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccagcagtgaacctcccagcGaagaccgcccgttcgacttc	9	17	0	2	rs143866681	byFrequency	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:74709847G>A	uc002slr.2	-	1	511	c.118C>T	c.(118-120)CGC>TGC	p.R40C	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.R40C|CCDC142_uc002slp.2_Missense_Mutation_p.R40C	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	40										central_nervous_system(1)	1						ACCTCCCAGCGAAGACCGCCC	0.682													0	0	0	0.004482	0	8	62										A	74709847	G	A	74709847	3	1	49	1	0	0	0	0	1	0	0	0	2776	1058	37	1	2149	1	CCDC142	2	74709847	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	10500956	74709847	168489526	15	13917										
C2orf51	200523	broad.mit.edu	37	chr2	88828645	88828645	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	accccaaccccaagctaacaGatgggtaccctgctttcaaa	6	15	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:88828645G>C	uc002stb.1	+	4	338	c.196G>C	c.(196-198)GAT>CAT	p.D66H		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	66						nucleus				skin(1)	1						CAAGCTAACAGATGGGTACCC	0.532													0	0	0	0.004482	0	8	84										C	88828645	G	C	88828645	3	2	49	1	0	0	0	0	1	0	0	0	2173	942	33	1	206	1	C2orf51	2	88828645	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	14118798	88828645	154370728	16	13918										
BUB1	699	broad.mit.edu	37	chr2	111427076	111427076	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tatttcctggatttgattttGatgttatcatttgatttaaa	6	3	1	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:111427076G>C	uc002tgc.2	-	6	633	c.521C>G	c.(520-522)TCA>TGA	p.S174*	BUB1_uc010yxh.1_Nonsense_Mutation_p.S154*|BUB1_uc010fkb.2_Nonsense_Mutation_p.S174*|BUB1_uc002tgd.2_Nonsense_Mutation_p.S174*	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	174	BUB1 N-terminal.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATTTGATTTTGATGTTATCAT	0.358													0	0	0	0.009096	0	4	116										C	111427076	G	C	111427076	4	2	49	1	0	0	0	0	0	1	0	0	1570	1294	45	1	2816	1	BUB1	2	111427076	Nonsense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	22598431	111427076	131772297	17	13919										
SCTR	6344	broad.mit.edu	37	chr2	120197742	120197742	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggctctgctccaagtggctgGccttggtgctgttgctgaag	15	10	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:120197742G>A	uc002tma.2	-	13	1500	c.1274C>T	c.(1273-1275)GCC>GTC	p.A425V	SCTR_uc002tlz.2_Missense_Mutation_p.A247V	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	425	Cytoplasmic (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	CAAGTGGCTGGCCTTGGTGCT	0.627													0	0	0	0.014758	0	5	24										A	120197742	G	A	120197742	3	1	49	1	0	0	0	0	1	0	0	0	13943	1203	42	2	52	2	SCTR	2	120197742	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	8770666	120197742	123001631	18	13920										
ARHGEF4	50649	broad.mit.edu	37	chr2	131799455	131799455	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cccagctcatcaacgagcggAagcggagacttgagaacatc	11	12	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:131799455A>C	uc002tsa.1	+	10	1925	c.1405A>C	c.(1405-1407)AAG>CAG	p.K469Q	ARHGEF4_uc010fmw.1_Intron|ARHGEF4_uc002tsb.1_Missense_Mutation_p.K469Q|ARHGEF4_uc010fmx.1_Missense_Mutation_p.K409Q|ARHGEF4_uc002tsc.1_Missense_Mutation_p.K12Q	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	469					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CAACGAGCGGAAGCGGAGACT	0.562													0	0	0	0.004672	0	3	58										C	131799455	A	C	131799455	3	2	49	1	0	0	0	0	1	0	0	0	908	247	9	5	1435	5	ARHGEF4	2	131799455	Missense_Mutation	SNP	A	TCGA-DK-A1AF-01A-11D-A13W-08	11601713	131799455	111399918	19	13921										
YSK4	80122	broad.mit.edu	37	chr2	135739074	135739074	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	attagctgtccttgactagtGagaccacagtatacctagaa	8	9	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:135739074G>A	uc002tue.1	-	9	3268	c.3237C>T	c.(3235-3237)CTC>CTT	p.L1079L	YSK4_uc002tuf.1_Silent_p.L261L|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Silent_p.L966L|YSK4_uc010zbg.1_Silent_p.L211L|YSK4_uc002tuh.3_Silent_p.L807L|YSK4_uc002tui.3_Missense_Mutation_p.S1147L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1079	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTTGACTAGTGAGACCACAGT	0.368													0	0	0	0.001984	0	7	199										A	135739074	G	A	135739074	2	1	49	1	0	0	0	0	0	0	0	1	17492	1277	45	1		1	YSK4	2	135739074	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	3939619	135739074	107460299	20	13922										
LRP1B	53353	broad.mit.edu	37	chr2	141641540	141641540	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tatccagtcgactgtcaggcCttctggagtagccaggccat	11	12	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:141641540C>T	uc002tvj.1	-	25	4987	c.4015G>A	c.(4015-4017)GGC>AGC	p.G1339S	LRP1B_uc010fnl.1_Missense_Mutation_p.G521S	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1339	Extracellular (Potential).|LDL-receptor class B 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTGTCAGGCCTTCTGGAGTA	0.468										TSP Lung(27;0.18)			0	0	0	0.024245	0	16	131										T	141641540	C	T	141641540	3	4	49	1	0	0	0	0	1	0	0	0	8955	681	24	2	10052	2	LRP1B	2	141641540	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	5902466	141641540	101557833	21	13923										
SLC4A10	57282	broad.mit.edu	37	chr2	162751249	162751249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acttggtatcaggaattgatGagtttctggatcaggttact	11	5	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:162751249G>C	uc002ubx.3	+	11	1439	c.1255G>C	c.(1255-1257)GAG>CAG	p.E419Q	SLC4A10_uc010fpa.1_Missense_Mutation_p.E431Q|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.E389Q|SLC4A10_uc010zcs.1_Missense_Mutation_p.E400Q	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	419	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						AGGAATTGATGAGTTTCTGGA	0.343													0	0	0	0.006214	0	8	94										C	162751249	G	C	162751249	3	2	49	1	0	0	0	0	1	0	0	0	14651	1291	45	1	1382	1	SLC4A10	2	162751249	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	21109709	162751249	80448124	22	13924										
FASTKD1	79675	broad.mit.edu	37	chr2	170416964	170416964	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttttacaaagctagcaggatGattacacagaggaatcattt	8	6	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:170416964G>A	uc002uev.3	-	5	1292	c.904C>T	c.(904-906)CAT>TAT	p.H302Y	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.H288Y|FASTKD1_uc002uey.2_Missense_Mutation_p.H265Y	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	302					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						CTAGCAGGATGATTACACAGA	0.299													0	0	0	0.008871	0	18	239										A	170416964	G	A	170416964	3	1	49	1	0	0	0	0	1	0	0	0	5685	1290	45	1	1683	1	FASTKD1	2	170416964	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	7665715	170416964	72782409	23	13925										
FASTKD1	79675	broad.mit.edu	37	chr2	170417266	170417266	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aatgtcgtgatattaaagaaGatatgttgaccatcaagaca	8	5	1	5			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:170417266G>T	uc002uev.3	-	5	990	c.602C>A	c.(601-603)TCT>TAT	p.S201Y	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.S187Y|FASTKD1_uc002uey.2_Missense_Mutation_p.S164Y	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	201					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TATTAAAGAAGATATGTTGAC	0.294													1	0	0.000602214	0.014758	0.000654298	4	48										T	170417266	G	T	170417266	3	4	49	1	0	0	0	0	1	0	0	0	5685	942	33	3	1985	3	FASTKD1	2	170417266	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	302	170417266	72782107	24	13926										
METTL8	79828	broad.mit.edu	37	chr2	172195788	172195788	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	agtctaggttggaaaaatcaGattctgttttgctttgacct	9	6	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:172195788G>A	uc010zdo.1	-	4	653	c.512C>T	c.(511-513)TCT>TTT	p.S171F	METTL8_uc002ugu.3_Missense_Mutation_p.S171F|METTL8_uc002ugv.3_Missense_Mutation_p.S171F|METTL8_uc002ugt.3_Missense_Mutation_p.S171F|METTL8_uc002ugs.3_Missense_Mutation_p.S121F|METTL8_uc010zdp.1_Missense_Mutation_p.S126F	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	methyltransferase like 8	171							methyltransferase activity			ovary(1)	1						GGAAAAATCAGATTCTGTTTT	0.383													0	0	0	0.020292	0	14	269										A	172195788	G	A	172195788	3	1	49	1	0	0	0	0	1	0	0	0	9507	942	33	1	739	1	METTL8	2	172195788	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	1778522	172195788	71003585	25	13927										
MAP2	4133	broad.mit.edu	37	chr2	210560016	210560016	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggaacaaggtctggattttgCtgtccagggtcaactagatg	13	7	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:210560016C>T	uc002vde.1	+	7	3370	c.3122C>T	c.(3121-3123)GCT>GTT	p.A1041V	MAP2_uc002vdc.1_Missense_Mutation_p.A1041V|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.A1037V	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1041					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTGGATTTTGCTGTCCAGGGT	0.443													0	0	0	0.014758	0	5	101										T	210560016	C	T	210560016	3	4	49	1	0	0	0	0	1	0	0	0	9235	797	28	2	3136	2	MAP2	2	210560016	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	38364228	210560016	32639357	26	13928										
SPHKAP	80309	broad.mit.edu	37	chr2	228883236	228883236	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttgatgacaagactcgtgttGtgtgaattgctaagtggaga	13	4	0	5			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr2:228883236G>T	uc002vpq.2	-	7	2381	c.2334C>A	c.(2332-2334)CAC>CAA	p.H778Q	SPHKAP_uc002vpp.2_Missense_Mutation_p.H778Q|SPHKAP_uc010zlx.1_Missense_Mutation_p.H778Q	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	778						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACTCGTGTTGTGTGAATTGC	0.512													1	0	1.80694e-10	0.009535	2.04043e-10	30	451										T	228883236	G	T	228883236	3	4	49	1	0	0	0	0	1	0	0	0	15047	1368	48	4	2792	4	SPHKAP	2	228883236	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	18323220	228883236	14316137	27	13929										
XYLB	9942	broad.mit.edu	37	chr3	38404477	38404477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggcttcgggcttcgacttctCtcaagtcctagccttgtccg	10	14	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:38404477C>T	uc003cic.2	+	4	369	c.260C>T	c.(259-261)TCT>TTT	p.S87F	XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_Missense_Mutation_p.S9F	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	87					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TTCGACTTCTCTCAAGTCCTA	0.522													0	0	0	0.014758	0	4	119										T	38404477	C	T	38404477	3	4	49	1	0	0	0	0	1	0	0	0	17459	913	32	1	274	1	XYLB	3	38404477	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		38404477	159617953	28	13930										
ZNF502	91392	broad.mit.edu	37	chr3	44763393	44763393	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aatgtggcaaagccttttgtCagagcccatctcttattaaa	7	9	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:44763393C>G	uc011baa.1	+	4	1339	c.1084C>G	c.(1084-1086)CAG>GAG	p.Q362E	ZNF502_uc003cns.2_Missense_Mutation_p.Q362E|ZNF502_uc011bab.1_Missense_Mutation_p.Q362E|ZNF502_uc003cnt.2_Missense_Mutation_p.Q362E	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	362	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGCCTTTTGTCAGAGCCCATC	0.408													0	0	0	0.001984	0	7	72										G	44763393	C	G	44763393	3	3	49	1	0	0	0	0	1	0	0	0	17947	827	29	1	1090	1	ZNF502	3	44763393	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	6358916	44763393	153259037	29	13931										
PRSS45	377047	broad.mit.edu	37	chr3	46783844	46783844	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggaaaaggtagggaggtcagGagcccatctggggctgcagc	18	8	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:46783844G>A	uc010hjl.2	-	4	683	c.683C>T	c.(682-684)TCC>TTC	p.S228F	PRSS45_uc011bam.1_RNA	NM_199183	NP_954652	Q7RTY3	PRS45_HUMAN	testis serine protease 5	260					proteolysis		serine-type endopeptidase activity				0						GGGAGGTCAGGAGCCCATCTG	0.552													0	0	0	0.00308	0	7	168										A	46783844	G	A	46783844	3	1	49	1	0	0	0	0	1	0	0	0	12629	1174	41	1	7	1	PRSS45	3	46783844	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	2020451	46783844	151238586	30	13932										
PVRL3	25945	broad.mit.edu	37	chr3	110845149	110845149	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aagtgaccaattcccttggtCaaagaagtgaccaaaaagtc	8	9	1	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:110845149C>T	uc003dxt.1	+	5	1036	c.1036C>T	c.(1036-1038)CAA>TAA	p.Q346*	PVRL3_uc003dxu.1_Nonsense_Mutation_p.Q323*	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	346	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						TTCCCTTGGTCAAAGAAGTGA	0.313													0	0	0	0.021553	0	5	62										T	110845149	C	T	110845149	4	4	49	1	0	0	0	0	0	1	0	0	12841	827	29	1	1054	1	PVRL3	3	110845149	Nonsense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	64061305	110845149	87177281	31	13933										
MUC13	56667	broad.mit.edu	37	chr3	124646827	124646827	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acagcatcagctgagttgccTtggttggtggctggaggaac	15	8	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:124646827T>C	uc003ehq.1	-	2	87	c.63A>G	c.(61-63)CAA>CAG	p.Q21Q		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	21	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						CTGAGTTGCCTTGGTTGGTGG	0.418													0	0	0	0.004672	0	3	140										C	124646827	T	C	124646827	2	2	49	1	0	0	0	0	0	0	0	1	9971	1606	56	5		5	MUC13	3	124646827	Silent	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08	13801678	124646827	73375603	32	13934										
SLC41A3	54946	broad.mit.edu	37	chr3	125726027	125726027	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tccagggcctggtgccaagtCagccgaaccatcacttctgc	10	15	3	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:125726027C>T	uc003eij.2	-	11	1522	c.1296G>A	c.(1294-1296)CTG>CTA	p.L432L	SLC41A3_uc003eii.2_Silent_p.L406L|SLC41A3_uc003eil.2_Silent_p.L432L|SLC41A3_uc003eik.2_Silent_p.L396L|SLC41A3_uc011bkh.1_Silent_p.L315L	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	432						integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		GGTGCCAAGTCAGCCGAACCA	0.547													0	0	0	0.014758	0	4	46										T	125726027	C	T	125726027	2	4	49	1	0	0	0	0	0	0	0	1	14631	813	29	1		1	SLC41A3	3	125726027	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	1079200	125726027	72296403	33	13935										
DNAJC13	23317	broad.mit.edu	37	chr3	132166277	132166277	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gtcagaaactttaaaattttCtacagagcacagaacagaac	6	8	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:132166277C>T	uc003eor.2	+	4	322	c.257C>T	c.(256-258)TCT>TTT	p.S86F	DNAJC13_uc010htq.1_Missense_Mutation_p.S86F	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	86							heat shock protein binding			ovary(1)|breast(1)	2						TTAAAATTTTCTACAGAGCAC	0.353													0	0	0	0.021553	0	5	83										T	132166277	C	T	132166277	3	4	49	1	0	0	0	0	1	0	0	0	4632	913	32	1	267	1	DNAJC13	3	132166277	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	6440250	132166277	65856153	34	13936										
CHST2	9435	broad.mit.edu	37	chr3	142840871	142840871	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tctgcaatagtatggctaagAcgctgcagacagccctgcag	11	11	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:142840871A>G	uc003evm.2	+	2	2102	c.1213A>G	c.(1213-1215)ACG>GCG	p.T405A		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	405	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						TATGGCTAAGACGCTGCAGAC	0.652													0	0	0	0.009096	0	4	63										G	142840871	A	G	142840871	3	3	49	1	0	0	0	0	1	0	0	0	3404	275	10	5	1215	5	CHST2	3	142840871	Missense_Mutation	SNP	A	TCGA-DK-A1AF-01A-11D-A13W-08	10674594	142840871	55181559	35	13937										
LAMP3	27074	broad.mit.edu	37	chr3	182853541	182853541	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atcttcaaaatcaaaggcttGaagttggacatcggttgttt	9	6	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:182853541G>C	uc003flh.3	-	5	1305	c.1081C>G	c.(1081-1083)CAA>GAA	p.Q361E		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	361	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TCAAAGGCTTGAAGTTGGACA	0.478													0	0	0	0.021523	0	26	297										C	182853541	G	C	182853541	3	2	49	1	0	0	0	0	1	0	0	0	8619	1299	45	1	177	1	LAMP3	3	182853541	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	40012670	182853541	15168889	36	13938										
HRG	3273	broad.mit.edu	37	chr3	186383944	186383944	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tagacctgatcaataaaaggCgacgggatggctaccttttc	10	9	1	2	rs146244921	by1000genomes	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:186383944C>T	uc003fqq.2	+	1	147	c.124C>T	c.(124-126)CGA>TGA	p.R42*		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	42	Cystatin 1.|Interaction with ATP5A1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CAATAAAAGGCGACGGGATGG	0.512													0	0	0	0.004482	0	9	82										T	186383944	C	T	186383944	4	4	49	1	0	0	0	0	0	1	0	0	7354	760	27	2	126	2	HRG	3	186383944	Nonsense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	3530403	186383944	11638486	37	13939										
TNK2	10188	broad.mit.edu	37	chr3	195593873	195593873	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgggccgcagacccagcccGaagagctgctccacctgggg	14	16	0	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:195593873G>A	uc003fvu.1	-	14	3540	c.2997C>T	c.(2995-2997)TTC>TTT	p.F999F	TNK2_uc003fvq.1_Silent_p.F408F|TNK2_uc003fvr.1_Silent_p.F526F|TNK2_uc003fvs.1_Silent_p.F1001F|TNK2_uc003fvt.1_Silent_p.F1047F	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	999				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	GACCCAGCCCGAAGAGCTGCT	0.697													0	0	0	0.009096	0	3	21										A	195593873	G	A	195593873	2	1	49	1	0	0	0	0	0	0	0	1	16315	1049	37	1		1	TNK2	3	195593873	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	9209929	195593873	2428557	38	13940										
IQCG	84223	broad.mit.edu	37	chr3	197665561	197665561	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tggcaagttgggtccttcctCagttattaacggactgggta	12	8	1	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr3:197665561C>T	uc003fyo.2	-	4	519	c.373G>A	c.(373-375)GAG>AAG	p.E125K	IQCG_uc003fyn.2_Missense_Mutation_p.E27K|IQCG_uc003fyp.2_Missense_Mutation_p.E125K|IQCG_uc003fyq.3_Missense_Mutation_p.E125K	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	125											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GGTCCTTCCTCAGTTATTAAC	0.413													0	0	0	0.019004	0	33	497										T	197665561	C	T	197665561	3	4	49	1	0	0	0	0	1	0	0	0	7810	835	29	1	990	1	IQCG	3	197665561	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2071688	197665561	356869	39	13941										
DGKQ	1609	broad.mit.edu	37	chr4	954890	954890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cggggcctggacccagggctCcccgtccacctgcaccgggg	15	18	0	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:954890C>T	uc003gbw.2	-	22	2748	c.2674G>A	c.(2674-2676)GAG>AAG	p.E892K	DGKQ_uc010ibn.2_Missense_Mutation_p.E879K	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	892					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			ACCCAGGGCTCCCCGTCCACC	0.692													0	0	0	0.009096	0	4	28										T	954890	C	T	954890	3	4	49	1	0	0	0	0	1	0	0	0	4473	864	30	1	162	1	DGKQ	4	954890	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		954890	190199386	40	13942										
TBC1D1	23216	broad.mit.edu	37	chr4	37903928	37903928	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccggctttgcgtttcaccctCtggactgagatgtgaacctg	11	12	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:37903928C>T	uc003gtb.2	+	2	555	c.212C>T	c.(211-213)TCT>TTT	p.S71F	TBC1D1_uc011byd.1_Missense_Mutation_p.S71F|TBC1D1_uc010ifd.2_Missense_Mutation_p.S71F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	71						nucleus	Rab GTPase activator activity			ovary(1)	1						GTTTCACCCTCTGGACTGAGA	0.547													0	0	0	0.001984	0	6	168										T	37903928	C	T	37903928	3	4	49	1	0	0	0	0	1	0	0	0	15594	913	32	1	214	1	TBC1D1	4	37903928	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	36949038	37903928	153250348	41	13943										
LRRC66	339977	broad.mit.edu	37	chr4	52860928	52860928	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttggaaggtaacattttcctCaagactgtctacagccgtca	8	10	3	1	rs76998469		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:52860928C>T	uc003gzi.2	-	4	2273	c.2260G>A	c.(2260-2262)GAG>AAG	p.E754K		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	754						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						ACATTTTCCTCAAGACTGTCT	0.483													0	0	0	0.00308	0	7	120										T	52860928	C	T	52860928	3	4	49	1	0	0	0	0	1	0	0	0	9018	835	29	1	386	1	LRRC66	4	52860928	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	14957000	52860928	138293348	42	13944										
KDR	3791	broad.mit.edu	37	chr4	55961744	55961744	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aggattaggagatgacatacCttgtaggggacaaattcatt	11	5	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:55961744C>T	uc003has.2	-	20	3119	c.2817G>A	c.(2815-2817)AAG>AAA	p.K939K	KDR_uc003hat.1_Silent_p.K939K	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	939	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATGACATACCTTGTAGGGGA	0.413			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.004482	0	8	99										T	55961744	C	T	55961744	2	4	49	1	0	0	0	0	0	0	0	1	8139	695	24	2		2	KDR	4	55961744	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	3100816	55961744	135192532	43	13945										
FRAS1	80144	broad.mit.edu	37	chr4	79294005	79294005	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttttaccaggactcgggcctCtgcaagagtaagtgtgtaga	12	8	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:79294005C>G	uc003hlb.2	+	24	3443	c.3003C>G	c.(3001-3003)CTC>CTG	p.L1001L	FRAS1_uc003hkw.2_Silent_p.L1001L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1001	FU 13.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACTCGGGCCTCTGCAAGAGTA	0.537													0	0	0	0.006214	0	8	86										G	79294005	C	G	79294005	2	3	49	1	0	0	0	0	0	0	0	1	6042	900	32	1		1	FRAS1	4	79294005	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	23332261	79294005	111860271	44	13946										
SMARCAD1	56916	broad.mit.edu	37	chr4	95129666	95129666	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	caccaatttctcttagtgctGaagaggagaatgctgaaggg	12	7	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:95129666G>A	uc003htc.3	+	2	376	c.121G>A	c.(121-123)GAA>AAA	p.E41K	SMARCAD1_uc003htb.3_Missense_Mutation_p.E41K|SMARCAD1_uc003htd.3_Missense_Mutation_p.E41K|SMARCAD1_uc010ila.2_5'UTR	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	41					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TCTTAGTGCTGAAGAGGAGAA	0.438													0	0	0	0.006214	0	7	127										A	95129666	G	A	95129666	3	1	49	1	0	0	0	0	1	0	0	0	14772	1291	45	1	123	1	SMARCAD1	4	95129666	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	15835661	95129666	96024610	45	13947										
KIAA1109	84162	broad.mit.edu	37	chr4	123166210	123166210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggttcattgtgctagtacccGacatccagctgcaattgtag	10	10	1	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:123166210G>A	uc003ieh.2	+	30	4997	c.4952G>A	c.(4951-4953)CGA>CAA	p.R1651Q	KIAA1109_uc003iek.2_Missense_Mutation_p.R270Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1651					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GCTAGTACCCGACATCCAGCT	0.343													0	0	0	0.00308	0	8	192										A	123166210	G	A	123166210	3	1	49	1	0	0	0	0	1	0	0	0	8208	1058	37	1	5070	1	KIAA1109	4	123166210	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	28036544	123166210	67988066	46	13948										
ARHGAP10	79658	broad.mit.edu	37	chr4	148743974	148743974	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	agatgatgaacgatgcatagGtaattaaacatgatattttg	9	3	0	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:148743974G>A	uc003ilf.2	+	2	250	c.250_splice	c.e2+1	p.D84_splice	ARHGAP10_uc003ile.1_Splice_Site_p.D84_splice	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CGATGCATAGGTAATTAAACA	0.393													0	0	0	0.009096	0	4	152										A	148743974	G	A	148743974	5	1	49	1	0	0	0	0	0	0	1	0	862	1275	44	2	257	2	ARHGAP10	4	148743974	Splice_Site	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	25577764	148743974	42410302	47	13949										
DCLK2	166614	broad.mit.edu	37	chr4	151023764	151023764	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgcctcctctgtgaaaagtGaagtaaaagaaagtaaagat	9	6	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr4:151023764G>A	uc003ilm.3	+	2	656	c.556G>A	c.(556-558)GAA>AAA	p.E186K	DCLK2_uc003iln.3_Missense_Mutation_p.E186K|DCLK2_uc003ilo.3_Missense_Mutation_p.E186K|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	186					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					TGTGAAAAGTGAAGTAAAAGA	0.428													0	0	0	0.008291	0	10	53										A	151023764	G	A	151023764	3	1	49	1	0	0	0	0	1	0	0	0	4292	1291	45	1	562	1	DCLK2	4	151023764	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	2279790	151023764	40130512	48	13950										
F2R	2149	broad.mit.edu	37	chr5	76028929	76028929	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acggtctgttatgtgtctatCattcgatgtcttagctcttc	8	9	5	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:76028929C>G	uc003ken.3	+	2	1144	c.879C>G	c.(877-879)ATC>ATG	p.I293M		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	293	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity	p.I293I(1)		ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	ATGTGTCTATCATTCGATGTC	0.483													0	0	0	0.00308	0	8	137										G	76028929	C	G	76028929	3	3	49	1	0	0	0	0	1	0	0	0	5343	816	29	1	885	1	F2R	5	76028929	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		76028929	104886331	49	13951										
FAT2	2196	broad.mit.edu	37	chr5	150920280	150920280	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccttgaggaaatcctccactCatctccaacttggctgatgc	7	14	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:150920280C>G	uc003lue.3	-	10	8900	c.8887G>C	c.(8887-8889)GAG>CAG	p.E2963Q	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2963	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCCTCCACTCATCTCCAACT	0.527													0	0	0	0.009096	0	4	69										G	150920280	C	G	150920280	3	3	49	1	0	0	0	0	1	0	0	0	5690	835	29	1	4218	1	FAT2	5	150920280	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	74891351	150920280	29994980	50	13952										
BNIP1	662	broad.mit.edu	37	chr5	172571562	172571562	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccccaacatggcggctccccAagacgtccacgtccggatct	9	18	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr5:172571562A>C	uc003mcj.3	+	1	118	c.14A>C	c.(13-15)CAA>CCA	p.Q5P	BNIP1_uc003mci.3_Missense_Mutation_p.Q5P|BNIP1_uc003mck.3_Missense_Mutation_p.Q5P|BNIP1_uc003mcl.3_Missense_Mutation_p.Q5P	NM_001205	NP_001196	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 1	5	Cytoplasmic (Potential).				anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCGGCTCCCCAAGACGTCCAC	0.607											OREG0017054	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	4	12										C	172571562	A	C	172571562	3	2	49	1	0	0	0	0	1	0	0	0	1476	130	5	5	16	5	BNIP1	5	172571562	Missense_Mutation	SNP	A	TCGA-DK-A1AF-01A-11D-A13W-08	21651282	172571562	8343698	51	13953										
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333833	28333833	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acctgagcagggagaggcctGgaaaagtaggatggaaagcc	16	7	0	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:28333833G>A	uc003nle.3	+	6	1604	c.1388G>A	c.(1387-1389)TGG>TAG	p.W463*	ZKSCAN3_uc010jrc.2_Nonsense_Mutation_p.W463*|ZKSCAN3_uc003nlf.3_Nonsense_Mutation_p.W315*|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	463				QGEAWKSRMESQLENVETPMS -> TGRGWKVGWKASWKML KLPCP (in Ref. 5; AAB16813).	positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GGAGAGGCCTGGAAAAGTAGG	0.433													0	0	0	0.021553	0	5	60										A	28333833	G	A	28333833	4	1	49	1	0	0	0	0	0	1	0	0	17685	1357	47	2	1406	2	ZKSCAN3	6	28333833	Nonsense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		28333833	142781234	52	13954										
MDC1	9656	broad.mit.edu	37	chr6	30670531	30670531	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	taaaagatagcctctcacctCtagcagccttcgctcccgag	7	15	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:30670531C>T	uc003nrg.3	-	13	6429	c.5989G>A	c.(5989-5991)GAG>AAG	p.E1997K	MDC1_uc003nrf.3_Missense_Mutation_p.E628K	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1997	Required for nuclear localization (NLS2).|BRCT 2.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CCTCTCACCTCTAGCAGCCTT	0.512								Other_conserved_DNA_damage_response_genes					0	0	0	0.020292	0	13	196										T	30670531	C	T	30670531	3	4	49	1	0	0	0	0	1	0	0	0	9403	922	32	1	292	1	MDC1	6	30670531	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2336698	30670531	140444536	53	13955										
C6orf27	80737	broad.mit.edu	37	chr6	31734536	31734536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttctaccagcagctgggtctGaagacctgggacaggggcga	15	10	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:31734536G>C	uc011dog.1	-	14	2126	c.1888C>G	c.(1888-1890)CAG>GAG	p.Q630E	C6orf27_uc003nxd.2_Missense_Mutation_p.Q305E	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	630						extracellular region				ovary(3)	3						AGCTGGGTCTGAAGACCTGGG	0.493													0	0	0	0.009096	0	4	52										C	31734536	G	C	31734536	3	2	49	1	0	0	0	0	1	0	0	0	2362	1299	45	1	802	1	C6orf27	6	31734536	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	1064005	31734536	139380531	54	13956										
C6orf27	80737	broad.mit.edu	37	chr6	31735227	31735227	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tcatccatggtcaccatccaGaactgcccaaagcggcgagt	9	14	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:31735227G>C	uc011dog.1	-	12	1939	c.1701C>G	c.(1699-1701)TTC>TTG	p.F567L	C6orf27_uc003nxd.2_Missense_Mutation_p.F242L	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	567						extracellular region				ovary(3)	3						TCACCATCCAGAACTGCCCAA	0.602													0	0	0	0.004482	0	6	108										C	31735227	G	C	31735227	3	2	49	1	0	0	0	0	1	0	0	0	2362	933	33	1	997	1	C6orf27	6	31735227	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	691	31735227	139379840	55	13957										
TCP11	6954	broad.mit.edu	37	chr6	35088708	35088708	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggctgcttattgaggagttcCtggaatttagcccgttcata	11	8	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:35088708C>T	uc003okd.2	-	6	913	c.732G>A	c.(730-732)CAG>CAA	p.Q244Q	TCP11_uc003ojz.1_Silent_p.Q169Q|TCP11_uc003oka.2_Silent_p.Q169Q|TCP11_uc003okb.2_Silent_p.Q168Q|TCP11_uc003okc.2_Silent_p.Q168Q|TCP11_uc011dsu.1_Silent_p.Q226Q|TCP11_uc011dsv.1_Silent_p.Q193Q|TCP11_uc011dsw.1_Silent_p.Q198Q	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	231					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						TGAGGAGTTCCTGGAATTTAG	0.443													0	0	0	0.01441	0	45	534										T	35088708	C	T	35088708	2	4	49	1	0	0	0	0	0	0	0	1	15710	680	24	2		2	TCP11	6	35088708	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	3353481	35088708	136026359	56	13958										
ABCC10	89845	broad.mit.edu	37	chr6	43400436	43400436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tggcccgtggggcctgtggaGagctccggcagcctcaggac	17	13	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:43400436G>A	uc003ouy.1	+	3	933	c.718G>A	c.(718-720)GAG>AAG	p.E240K	ABCC10_uc003ouz.1_Missense_Mutation_p.E197K	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	240						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCTGTGGAGAGCTCCGGCA	0.637													0	0	0	0.021553	0	5	56										A	43400436	G	A	43400436	3	1	49	1	0	0	0	0	1	0	0	0	50	943	33	1	591	1	ABCC10	6	43400436	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	8311728	43400436	127714631	57	13959										
SLC17A5	26503	broad.mit.edu	37	chr6	74345112	74345112	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tcaaagtccatacctgatttCttaatgatgaaagaatgtat	6	6	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:74345112C>G	uc003phn.3	-	6	940	c.812G>C	c.(811-813)AGA>ACA	p.R271T	SLC17A5_uc010kax.2_5'UTR|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Missense_Mutation_p.R140T	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	271			Missing (in ISSD).		anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						TACCTGATTTCTTAATGATGA	0.274													0	0	0	0.013537	0	12	94										G	74345112	C	G	74345112	3	3	49	1	0	0	0	0	1	0	0	0	14420	913	32	1	699	1	SLC17A5	6	74345112	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	30944676	74345112	96769955	58	13960										
DOPEY1	23033	broad.mit.edu	37	chr6	83845382	83845382	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccttaacagtctcgatggttCtactagctctgtgggacaag	10	10	3	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:83845382C>T	uc003pjs.1	+	20	3175	c.2915C>T	c.(2914-2916)TCT>TTT	p.S972F	DOPEY1_uc011dyy.1_Missense_Mutation_p.S963F|DOPEY1_uc010kbl.1_Missense_Mutation_p.S963F|DOPEY1_uc003pjt.2_5'Flank	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	972					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTCGATGGTTCTACTAGCTCT	0.393													0	0	0	0.020292	0	14	182										T	83845382	C	T	83845382	3	4	49	1	0	0	0	0	1	0	0	0	4707	913	32	1	2985	1	DOPEY1	6	83845382	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	9500270	83845382	87269685	59	13961										
EZR	7430	broad.mit.edu	37	chr6	159191809	159191809	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gcctgacctctctctgccttCtttgtcttctcctcatagtc	5	16	6	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr6:159191809C>G	uc003qrt.3	-	9	1292	c.1077G>C	c.(1075-1077)AAG>AAC	p.K359N	EZR_uc011efr.1_5'Flank|EZR_uc011efs.1_Missense_Mutation_p.K327N|EZR_uc003qru.3_Missense_Mutation_p.K359N	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	359	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCTCTGCCTTCTTTGTCTTCT	0.567													0	0	0	0.008291	0	10	149										G	159191809	C	G	159191809	3	3	49	1	0	0	0	0	1	0	0	0	5335	912	32	1	703	1	EZR	6	159191809	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	75346427	159191809	11923258	60	13962										
FOXK1	221937	broad.mit.edu	37	chr7	4794948	4794948	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	caggaccggcagctgaccctGagcgggatctacgcccacat	12	15	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:4794948G>C	uc003snc.1	+	4	994	c.984G>C	c.(982-984)CTG>CTC	p.L328L	FOXK1_uc003sna.1_Silent_p.L165L|FOXK1_uc003snb.1_3'UTR	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	forkhead box K1	328	Fork-head.				cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			upper_aerodigestive_tract(1)|skin(1)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		AGCTGACCCTGAGCGGGATCT	0.642													0	0	0	0.001984	0	6	54										C	4794948	G	C	4794948	2	2	49	1	0	0	0	0	0	0	0	1	6014	1277	45	1		1	FOXK1	7	4794948	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		4794948	154343715	61	13963										
MLXIPL	51085	broad.mit.edu	37	chr7	73010266	73010266	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgtagcataaggatgtactCagctgtcttctgcagcgtgg	12	9	3	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:73010266C>G	uc003tyn.1	-	14	2140	c.2092G>C	c.(2092-2094)GAG>CAG	p.E698Q	MLXIPL_uc003tyj.1_Missense_Mutation_p.E77Q|MLXIPL_uc003tyk.1_Intron|MLXIPL_uc003tyl.1_Missense_Mutation_p.E696Q|MLXIPL_uc003tym.1_Intron|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.E604Q	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	698	Helix-loop-helix motif.				anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGATGTACTCAGCTGTCTTC	0.607													0	0	0	0.014758	0	4	26										G	73010266	C	G	73010266	3	3	49	1	0	0	0	0	1	0	0	0	9637	835	29	1	482	1	MLXIPL	7	73010266	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	68215318	73010266	86128397	62	13964										
KIAA1324L	222223	broad.mit.edu	37	chr7	86556202	86556202	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gagatcctcccggcagatttTgggctctatccacttgtaca	9	12	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:86556202T>G	uc011kha.1	-	9	1305	c.1120A>C	c.(1120-1122)AAA>CAA	p.K374Q	KIAA1324L_uc003uif.1_Missense_Mutation_p.K134Q|KIAA1324L_uc011kgz.1_Missense_Mutation_p.K260Q|KIAA1324L_uc003uie.2_Missense_Mutation_p.K207Q	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	374	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CGGCAGATTTTGGGCTCTATC	0.378													0	0	0	0.014758	0	5	190										G	86556202	T	G	86556202	3	3	49	1	0	0	0	0	1	0	0	0	8224	1821	63	5	2025	5	KIAA1324L	7	86556202	Missense_Mutation	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08	13545936	86556202	72582461	63	13965										
DBF4	10926	broad.mit.edu	37	chr7	87516657	87516657	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tttacaggattttattccttCaaatagtatattatcaaatg	4	5	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:87516657C>T	uc003ujf.1	+	5	968	c.464C>T	c.(463-465)TCA>TTA	p.S155L	DBF4_uc003ujh.1_5'UTR|DBF4_uc003ujg.1_5'UTR|DBF4_uc011khf.1_5'UTR	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	155	BRCT 2.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TTTATTCCTTCAAATAGTATA	0.229													0	0	0	0.009096	0	4	36										T	87516657	C	T	87516657	3	4	49	1	0	0	0	0	1	0	0	0	4248	838	29	1	482	1	DBF4	7	87516657	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	960455	87516657	71622006	64	13966										
SAMD9	54809	broad.mit.edu	37	chr7	92734318	92734318	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctctgccagtgttttaaaatCtgctttaaatgctctgaaat	6	8	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:92734318C>G	uc003umf.2	-	3	1349	c.1093G>C	c.(1093-1095)GAT>CAT	p.D365H	SAMD9_uc003umg.2_Missense_Mutation_p.D365H	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	365						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTTTTAAAATCTGCTTTAAAT	0.333													0	0	0	0.008291	0	9	188										G	92734318	C	G	92734318	3	3	49	1	0	0	0	0	1	0	0	0	13826	913	32	1	3680	1	SAMD9	7	92734318	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	5217661	92734318	66404345	65	13967										
EPHB4	2050	broad.mit.edu	37	chr7	100410820	100410820	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	taagtgaaggggtcgatgtaGaccttagtacctgagaaatc	12	6	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:100410820G>A	uc003uwn.1	-	11	2258	c.1767C>T	c.(1765-1767)GTC>GTT	p.V589V	EPHB4_uc003uwm.1_Silent_p.V496V|EPHB4_uc010lhj.1_Silent_p.V589V	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	589	Cytoplasmic (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGTCGATGTAGACCTTAGTAC	0.507													0	0	0	0.009096	0	4	88										A	100410820	G	A	100410820	2	1	49	1	0	0	0	0	0	0	0	1	5177	929	33	1		1	EPHB4	7	100410820	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	7676502	100410820	58727843	66	13968										
C7orf60	154743	broad.mit.edu	37	chr7	112472660	112472660	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gccaacagttagaaattcttCaaacttcagaaatgggttaa	7	7	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:112472660C>G	uc003vgo.1	-	4	671	c.544G>C	c.(544-546)GAA>CAA	p.E182Q	C7orf60_uc011kms.1_Missense_Mutation_p.E208Q	NM_152556	NP_689769	Q1RMZ1	CG060_HUMAN	hypothetical protein LOC154743	182										ovary(2)|skin(1)	3						AGAAATTCTTCAAACTTCAGA	0.308													0	0	0	0.001984	0	6	133										G	112472660	C	G	112472660	3	3	49	1	0	0	0	0	1	0	0	0	2407	835	29	1	681	1	C7orf60	7	112472660	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	12061840	112472660	46666003	67	13969										
NOS3	4846	broad.mit.edu	37	chr7	150698385	150698385	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tcatgaagcacctggagaatGagcagaaggccagggggggc	17	8	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:150698385G>C	uc003wif.2	+	11	1596	c.1300G>C	c.(1300-1302)GAG>CAG	p.E434Q	NOS3_uc011kuy.1_Missense_Mutation_p.E228Q|NOS3_uc011kuz.1_Missense_Mutation_p.E434Q|NOS3_uc011kva.1_Missense_Mutation_p.E434Q|NOS3_uc011kvb.1_Missense_Mutation_p.E434Q	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	434	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCTGGAGAATGAGCAGAAGGC	0.612													0	0	0	0.00308	0	5	83										C	150698385	G	C	150698385	3	2	49	1	0	0	0	0	1	0	0	0	10544	1291	45	1	1338	1	NOS3	7	150698385	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	38225725	150698385	8440278	68	13970										
INSIG1	3638	broad.mit.edu	37	chr7	155094081	155094081	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tggggatcaccatagcttttCtagctacgctgatcacgcag	10	11	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr7:155094081C>T	uc003wly.2	+	4	869	c.658C>T	c.(658-660)CTA>TTA	p.L220L	INSIG1_uc011kvu.1_Silent_p.L68L|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1	220	Helical; (Potential).				cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATAGCTTTTCTAGCTACGCT	0.438													0	0	0	0.006214	0	9	107										T	155094081	C	T	155094081	2	4	49	1	0	0	0	0	0	0	0	1	7765	912	32	1		1	INSIG1	7	155094081	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	4395696	155094081	4044582	69	13971										
EXTL3	2137	broad.mit.edu	37	chr8	28575593	28575593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgatgttgacttatgagcggGaggaagtgcttatgaactct	13	5	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:28575593G>A	uc003xgz.1	+	3	2610	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	673	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TTATGAGCGGGAGGAAGTGCT	0.542													0	0	0	0.001984	0	7	97										A	28575593	G	A	28575593	3	1	49	1	0	0	0	0	1	0	0	0	5327	1175	41	1	2019	1	EXTL3	8	28575593	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		28575593	117788429	70	13972										
TEX15	56154	broad.mit.edu	37	chr8	30702398	30702398	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tctttagaagctctttttctCtacagctctgctcacagtgt	6	11	5	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:30702398C>G	uc003xil.2	-	1	4136	c.4136G>C	c.(4135-4137)AGA>ACA	p.R1379T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1379										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTCTTTTTCTCTACAGCTCTG	0.398													0	0	0	0.001984	0	6	174										G	30702398	C	G	30702398	3	3	49	1	0	0	0	0	1	0	0	0	15776	913	32	1	4249	1	TEX15	8	30702398	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2126805	30702398	115661624	71	13973										
WHSC1L1	54904	broad.mit.edu	37	chr8	38173473	38173473	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aatcggagtcagatgtgtctCtgtatgctgaactagtcatt	10	7	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:38173473C>G	uc003xli.2	-	10	2461	c.1943G>C	c.(1942-1944)AGA>ACA	p.R648T	WHSC1L1_uc011lbm.1_Missense_Mutation_p.R648T|WHSC1L1_uc010lwe.2_Missense_Mutation_p.R648T	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	648					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			AGATGTGTCTCTGTATGCTGA	0.433			T	NUP98	AML								0	0	0	0.021553	0	6	166										G	38173473	C	G	38173473	3	3	49	1	0	0	0	0	1	0	0	0	17360	913	32	1	2430	1	WHSC1L1	8	38173473	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	7471075	38173473	108190549	72	13974										
RIMS2	9699	broad.mit.edu	37	chr8	104898276	104898276	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atgttaaggaatgattctctCagttcagaccagtcagagtc	9	8	4	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr8:104898276C>G	uc003yls.2	+	2	1024	c.783C>G	c.(781-783)CTC>CTG	p.L261L	RIMS2_uc003ylp.2_Silent_p.L483L|RIMS2_uc003ylw.2_Silent_p.L291L|RIMS2_uc003ylq.2_Silent_p.L291L|RIMS2_uc003ylr.2_Silent_p.L291L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	514					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATGATTCTCTCAGTTCAGACC	0.438										HNSCC(12;0.0054)			0	0	0	0.00308	0	8	67										G	104898276	C	G	104898276	2	3	49	1	0	0	0	0	0	0	0	1	13368	813	29	1		1	RIMS2	8	104898276	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	66724803	104898276	41465746	73	13975										
CDC14B	8555	broad.mit.edu	37	chr9	99301371	99301371	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aagacttacttcatagtgttCatattcatcaaggttaaatg	6	6	4	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:99301371C>T	uc004awj.2	-	7	1068	c.616G>A	c.(616-618)GAA>AAA	p.E206K	CDC14B_uc004awk.2_Missense_Mutation_p.E206K|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.E169K	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	206	Linker.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TCATAGTGTTCATATTCATCA	0.279													0	0	0	0.001984	0	7	91										T	99301371	C	T	99301371	3	4	49	1	0	0	0	0	1	0	0	0	3057	835	29	1	912	1	CDC14B	9	99301371	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		99301371	41912060	74	13976										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													0	0	0	0.021553	0	5	86										T	137328351	C	T	137328351	3	4	49	1	0	0	0	0	1	0	0	0	13763	855	30	1	1318	1	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	38026980	137328351	3885080	75	13977										
ATAD1	84896	broad.mit.edu	37	chr10	89516664	89516664	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgggcaacttctagcaggtCtacatgcctatccaccttaa	7	13	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:89516664C>G	uc001key.1	-	8	1130	c.847G>C	c.(847-849)GAC>CAC	p.D283H	ATAD1_uc010qmr.1_Missense_Mutation_p.D195H|ATAD1_uc009xth.1_RNA|ATAD1_uc001kez.1_Missense_Mutation_p.D283H	NM_032810	NP_116199	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	283						peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)		TCTAGCAGGTCTACATGCCTA	0.353													0	0	0	0.021553	0	6	99										G	89516664	C	G	89516664	3	3	49	1	0	0	0	0	1	0	0	0	1070	913	32	1	246	1	ATAD1	10	89516664	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		89516664	46018083	76	13978										
MYOF	26509	broad.mit.edu	37	chr10	95147619	95147619	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atctggtggtgtcttctcaaGaaaagtggctaattcaacca	9	8	4	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:95147619G>A	uc001kin.2	-	19	1756	c.1633C>T	c.(1633-1635)CTT>TTT	p.L545F	MYOF_uc001kio.2_Missense_Mutation_p.L532F	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	545	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GTCTTCTCAAGAAAAGTGGCT	0.423													0	0	0	0.00308	0	6	166										A	95147619	G	A	95147619	3	1	49	1	0	0	0	0	1	0	0	0	10089	942	33	1	4696	1	MYOF	10	95147619	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	5630955	95147619	40387128	77	13979										
ARHGAP19	84986	broad.mit.edu	37	chr10	99025847	99025847	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgggctgacctcgaagggaaGaatcattgcagatcacaaaa	11	8	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:99025847G>C	uc001knb.2	-	2	121	c.92C>G	c.(91-93)TCT>TGT	p.S31C	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Missense_Mutation_p.S22C|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Missense_Mutation_p.S31C|ARHGAP19_uc009xvk.2_Intron	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	31					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		TCGAAGGGAAGAATCATTGCA	0.393													0	0	0	0.014758	0	5	84										C	99025847	G	C	99025847	3	2	49	1	0	0	0	0	1	0	0	0	869	942	33	1	1436	1	ARHGAP19	10	99025847	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	3878228	99025847	36508900	78	13980										
CHUK	1147	broad.mit.edu	37	chr10	101978578	101978578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atccttcttcttaatcttctCatgcctataaaatcaaaagc	2	11	5	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr10:101978578C>T	uc001kqp.2	-	8	749	c.694G>A	c.(694-696)GAG>AAG	p.E232K		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	232	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		TTAATCTTCTCATGCCTATAA	0.328													0	0	0	0.00308	0	8	93										T	101978578	C	T	101978578	3	4	49	1	0	0	0	0	1	0	0	0	3416	835	29	1	1599	1	CHUK	10	101978578	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2952731	101978578	33556169	79	13981										
OR52I2	143502	broad.mit.edu	37	chr11	4608745	4608745	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	acagtctgattggttcctctCttatggtgggctctgatgtg	12	8	3	2	rs137965376	byFrequency	TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:4608745C>T	uc010qyh.1	+	1	703	c.703C>T	c.(703-705)CTT>TTT	p.L235F		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	235	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGTTCCTCTCTTATGGTGGG	0.488													0	0	0	0.010504	0	19	257										T	4608745	C	T	4608745	3	4	49	1	0	0	0	0	1	0	0	0	11121	913	32	1	705	1	OR52I2	11	4608745	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		4608745	130397771	80	13982										
DEPDC7	91614	broad.mit.edu	37	chr11	33053051	33053051	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tagtgaaagaacttctgtttGatgccattggcagatattac	9	6	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33053051G>C	uc001mub.2	+	5	1002	c.910G>C	c.(910-912)GAT>CAT	p.D304H	DEPDC7_uc001muc.2_Missense_Mutation_p.D295H	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	304					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ACTTCTGTTTGATGCCATTGG	0.398													0	0	0	0.024245	0	10	124										C	33053051	G	C	33053051	3	2	49	1	0	0	0	0	1	0	0	0	4444	1290	45	1	978	1	DEPDC7	11	33053051	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	28444306	33053051	101953465	81	13983			1	53		5	5	1874	G		2.872538e-10
DEPDC7	91614	broad.mit.edu	37	chr11	33053080	33053080	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggcagatattacagtagtagGgaacctctgttaaatcactt	9	7	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33053080G>A	uc001mub.2	+	5	1031	c.939G>A	c.(937-939)AGG>AGA	p.R313R	DEPDC7_uc001muc.2_Silent_p.R304R	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	313					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ACAGTAGTAGGGAACCTCTGT	0.393													0	0	0	0.008291	0	7	129										A	33053080	G	A	33053080	2	1	49	1	0	0	0	0	0	0	0	1	4444	1223	43	2		2	DEPDC7	11	33053080	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	29	33053080	101953436	82	13984			1	53		5	5	1874	G		2.872538e-10
DEPDC7	91614	broad.mit.edu	37	chr11	33054239	33054239	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	caaccgaatggttgtgaaaaGgatattctcaaaagctattg	9	6	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054239G>C	uc001mub.2	+	7	1255	c.1163G>C	c.(1162-1164)AGG>ACG	p.R388T	DEPDC7_uc001muc.2_Missense_Mutation_p.R379T	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	388					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						GTTGTGAAAAGGATATTCTCA	0.259													0	0	0	0.024245	0	16	106										C	33054239	G	C	33054239	3	2	49	1	0	0	0	0	1	0	0	0	4444	1000	35	4	1239	4	DEPDC7	11	33054239	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	1159	33054239	101952277	83	13985			1	53		5	5	1874	G		2.872538e-10
DEPDC7	91614	broad.mit.edu	37	chr11	33054490	33054490	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gcttatggccatacagaacgGaagagatccaaatagagatg	11	7	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054490G>A	uc001mub.2	+	8	1411	c.1319G>A	c.(1318-1320)GGA>GAA	p.G440E	DEPDC7_uc001muc.2_Missense_Mutation_p.G431E	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	440					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						ATACAGAACGGAAGAGATCCA	0.318													0	0	0	0.008871	0	17	119										A	33054490	G	A	33054490	3	1	49	1	0	0	0	0	1	0	0	0	4444	1174	41	1	1399	1	DEPDC7	11	33054490	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	251	33054490	101952026	84	13986			1	53		5	5	1874	G		2.872538e-10
DEPDC7	91614	broad.mit.edu	37	chr11	33054924	33054924	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atgaggattcaaaactttctGccaaagagaagaaaaaattg	8	5	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:33054924G>A	uc001mub.2	+	9	1551	c.1459G>A	c.(1459-1461)GCC>ACC	p.A487T	DEPDC7_uc001muc.2_Missense_Mutation_p.A478T	NM_001077242	NP_001070710	Q96QD5	DEPD7_HUMAN	novel 58.3 KDA protein isoform 1	487					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|skin(1)	2						AAAACTTTCTGCCAAAGAGAA	0.333													0	0	0	0.001984	0	6	140										A	33054924	G	A	33054924	3	1	49	1	0	0	0	0	1	0	0	0	4444	1319	46	2	1543	2	DEPDC7	11	33054924	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	434	33054924	101951592	85	13987			1	53		5	5	1874	G		2.872538e-10
NAT10	55226	broad.mit.edu	37	chr11	34139781	34139781	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctcgtcattgatgaccagctCaacatcctgcccatctcctc	5	17	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:34139781C>G	uc001mvk.2	+	7	856	c.612C>G	c.(610-612)CTC>CTG	p.L204L	NAT10_uc010ren.1_Silent_p.L132L	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	204						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				ATGACCAGCTCAACATCCTGC	0.557													0	0	0	0.016723	0	10	60										G	34139781	C	G	34139781	2	3	49	1	0	0	0	0	0	0	0	1	10174	813	29	1		1	NAT10	11	34139781	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	1084857	34139781	100866735	86	13988										
PGM2L1	283209	broad.mit.edu	37	chr11	74056622	74056622	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gcatttcttgatttatttttCttccagcaatcaaacatcca	3	10	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:74056622C>T	uc001ovb.1	-	9	1406	c.1110G>A	c.(1108-1110)AAG>AAA	p.K370K		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	370					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					ATTTATTTTTCTTCCAGCAAT	0.373													0	0	0	0.021553	0	5	108										T	74056622	C	T	74056622	2	4	49	1	0	0	0	0	0	0	0	1	11799	912	32	1		1	PGM2L1	11	74056622	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	39916841	74056622	60949894	87	13989										
MAP6	4135	broad.mit.edu	37	chr11	75298367	75298367	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgtaggactgtggggccttGatccttaactagtactggga	13	8	0	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:75298367G>C	uc001owu.2	-	4	2244	c.2179C>G	c.(2179-2181)CAA>GAA	p.Q727E		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	727	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GTGGGGCCTTGATCCTTAACT	0.493													0	0	0	0.01892	0	25	221										C	75298367	G	C	75298367	3	2	49	1	0	0	0	0	1	0	0	0	9264	1299	45	1	266	1	MAP6	11	75298367	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	1241745	75298367	59708149	88	13990										
TSKU	25987	broad.mit.edu	37	chr11	76507357	76507357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cggggctgggaggccttacaCacctgtctctggccagcctg	14	14	1	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:76507357C>T	uc001oxt.2	+	2	869	c.697C>T	c.(697-699)CAC>TAC	p.H233Y		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	233	LRR 8.					extracellular region					0	Ovarian(111;0.112)					AGGCCTTACACACCTGTCTCT	0.667													0	0	0	0.004482	0	8	112										T	76507357	C	T	76507357	3	4	49	1	0	0	0	0	1	0	0	0	16624	478	17	2	699	2	TSKU	11	76507357	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	1208990	76507357	58499159	89	13991										
NPAT	4863	broad.mit.edu	37	chr11	108043955	108043955	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tagctgtgacataactggttCtaacacattaatttctattt	5	7	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:108043955C>T	uc001pjz.3	-	13	1858	c.1756G>A	c.(1756-1758)GAA>AAA	p.E586K	NPAT_uc001pka.2_Missense_Mutation_p.E381K	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	586					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		ATAACTGGTTCTAACACATTA	0.299													0	0	0	0.020292	0	14	231										T	108043955	C	T	108043955	3	4	49	1	0	0	0	0	1	0	0	0	10566	922	32	1	2551	1	NPAT	11	108043955	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	31536598	108043955	26962561	90	13992										
EXPH5	23086	broad.mit.edu	37	chr11	108382830	108382830	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gcttttttcttccttctcttCcagttgaggcatgtggctcc	8	12	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr11:108382830C>A	uc001pkk.2	-	6	3515	c.3404G>T	c.(3403-3405)GGA>GTA	p.G1135V	EXPH5_uc010rvy.1_Missense_Mutation_p.G947V|EXPH5_uc010rvz.1_Missense_Mutation_p.G979V|EXPH5_uc010rwa.1_Missense_Mutation_p.G1059V	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1135					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TCCTTCTCTTCCAGTTGAGGC	0.483													1	0	7.48243e-07	0.006214	8.30922e-07	8	129										A	108382830	C	A	108382830	3	1	49	1	0	0	0	0	1	0	0	0	5322	855	30	3	2569	3	EXPH5	11	108382830	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	338875	108382830	26623686	91	13993										
A2ML1	144568	broad.mit.edu	37	chr12	9020914	9020914	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aaaagctagatgtgagcaacCgacttcacctcgatccttga	8	11	1	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:9020914C>A	uc001quz.3	+	31	4120	c.4022C>A	c.(4021-4023)CCG>CAG	p.P1341Q	A2ML1_uc001qva.1_Missense_Mutation_p.P921Q|A2ML1_uc010sgm.1_Missense_Mutation_p.P841Q|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1185						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TGTGAGCAACCGACTTCACCT	0.488													1	0	1.15088e-07	0.028581	1.29233e-07	17	254										A	9020914	C	A	9020914	3	1	49	1	0	0	0	0	1	0	0	0	5	652	23	4	4144	4	A2ML1	12	9020914	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		9020914	124830981	92	13994										
STYK1	55359	broad.mit.edu	37	chr12	10780303	10780303	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tctgtgagatcatagagaagAccatccatagtcatcacatc	7	10	4	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:10780303A>C	uc001qys.2	-	7	1175	c.654T>G	c.(652-654)GGT>GGG	p.G218G		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	218	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						CATAGAGAAGACCATCCATAG	0.398										HNSCC(73;0.22)			0	0	0	0.016723	0	9	72										C	10780303	A	C	10780303	2	2	49	1	0	0	0	0	0	0	0	1	15358	262	10	5		5	STYK1	12	10780303	Silent	SNP	A	TCGA-DK-A1AF-01A-11D-A13W-08	1759389	10780303	123071592	93	13995										
TAS2R9	50835	broad.mit.edu	37	chr12	10962188	10962188	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gaatttccaagtaatgttttCttcatgactgactttgaaaa	6	6	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:10962188C>G	uc001qyx.2	-	1	580	c.487G>C	c.(487-489)GAA>CAA	p.E163Q	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	163	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GTAATGTTTTCTTCATGACTG	0.378													0	0	0	0.016723	0	12	107										G	10962188	C	G	10962188	3	3	49	1	0	0	0	0	1	0	0	0	15585	922	32	1	455	1	TAS2R9	12	10962188	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	181885	10962188	122889707	94	13996										
CMAS	55907	broad.mit.edu	37	chr12	22208488	22208488	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tcgagaagaaggatatgattCtgttttctctgttgtgagac	11	5	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:22208488C>G	uc001rfm.2	+	3	582	c.503C>G	c.(502-504)TCT>TGT	p.S168C	CMAS_uc001rfn.2_RNA	NM_018686	NP_061156	Q8NFW8	NEUA_HUMAN	cytidine monophospho-N-acetylneuraminic acid	168					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			ovary(1)|pancreas(1)|skin(1)	3						GGATATGATTCTGTTTTCTCT	0.353													0	0	0	0.001984	0	7	114										G	22208488	C	G	22208488	3	3	49	1	0	0	0	0	1	0	0	0	3575	913	32	1	513	1	CMAS	12	22208488	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	11246300	22208488	111643407	95	13997										
ACVRL1	94	broad.mit.edu	37	chr12	52309201	52309201	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggagatcttcggtacacaggGcaaaccagccattgcccacc	10	14	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:52309201G>A	uc001rzj.2	+	7	1248	c.965G>A	c.(964-966)GGC>GAC	p.G322D	ACVRL1_uc001rzk.2_Missense_Mutation_p.G322D|ACVRL1_uc010snm.1_Missense_Mutation_p.G148D	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	322	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GGTACACAGGGCAAACCAGCC	0.642									Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.014758	0	3	25										A	52309201	G	A	52309201	3	1	49	1	0	0	0	0	1	0	0	0	225	1203	42	2	987	2	ACVRL1	12	52309201	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	30100713	52309201	81542694	96	13998										
GRASP	160622	broad.mit.edu	37	chr12	52404711	52404711	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ataaccagaccttcggctttGagatccaggtgggagaagct	12	9	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:52404711G>C	uc001rzo.1	+	3	399	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	GRASP_uc001rzp.1_5'UTR	NM_181711	NP_859062	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides	115	PDZ.					cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CTTCGGCTTTGAGATCCAGGT	0.547													0	0	0	0.010729	0	11	134										C	52404711	G	C	52404711	3	2	49	1	0	0	0	0	1	0	0	0	6755	1291	45	1	353	1	GRASP	12	52404711	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	95510	52404711	81447184	97	13999										
ESPL1	9700	broad.mit.edu	37	chr12	53662888	53662888	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	caagcttgtgatgccatcctGagggcttgcaaccagcagct	11	12	0	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:53662888G>A	uc001sck.2	+	3	253	c.162G>A	c.(160-162)CTG>CTA	p.L54L	ESPL1_uc001scj.2_5'UTR	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	54					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						ATGCCATCCTGAGGGCTTGCA	0.552													0	0	0	0.001984	0	6	91										A	53662888	G	A	53662888	2	1	49	1	0	0	0	0	0	0	0	1	5253	1277	45	1		1	ESPL1	12	53662888	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	1258177	53662888	80189007	98	14000										
NCKAP1L	3071	broad.mit.edu	37	chr12	54894397	54894397	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	taccagtcatttgtggatgtCatggaatttcgggtgagctc	12	7	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:54894397C>T	uc001sgc.3	+	3	373	c.294C>T	c.(292-294)GTC>GTT	p.V98V	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Silent_p.V48V	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	98					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TTGTGGATGTCATGGAATTTC	0.398													0	0	0	0.016723	0	13	181										T	54894397	C	T	54894397	2	4	49	1	0	0	0	0	0	0	0	1	10222	813	29	1		1	NCKAP1L	12	54894397	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	1231509	54894397	78957498	99	14001										
NCKAP1L	3071	broad.mit.edu	37	chr12	54912718	54912718	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttgataatggagaaaaatttGaattctcaggattgaggctg	11	3	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:54912718G>C	uc001sgc.3	+	15	1520	c.1441G>C	c.(1441-1443)GAA>CAA	p.E481Q	NCKAP1L_uc010sox.1_Missense_Mutation_p.E23Q|NCKAP1L_uc010soy.1_Missense_Mutation_p.E431Q	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	481					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						AGAAAAATTTGAATTCTCAGG	0.403													0	0	0	0.004482	0	8	72										C	54912718	G	C	54912718	3	2	49	1	0	0	0	0	1	0	0	0	10222	1291	45	1	1499	1	NCKAP1L	12	54912718	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	18321	54912718	78939177	100	14002										
C12orf66	144577	broad.mit.edu	37	chr12	64587993	64587993	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	accatgaccctgaaaactctCagaacctctgttgtcaaaaa	5	12	3	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:64587993C>T	uc001srw.3	-	3	1026	c.967G>A	c.(967-969)GAG>AAG	p.E323K	C12orf66_uc009zql.2_Missense_Mutation_p.E270K	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	323										ovary(1)	1						TGAAAACTCTCAGAACCTCTG	0.473													0	0	0	0.016723	0	12	174										T	64587993	C	T	64587993	3	4	49	1	0	0	0	0	1	0	0	0	1709	835	29	1	374	1	C12orf66	12	64587993	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	9675275	64587993	69263902	101	14003										
C12orf66	144577	broad.mit.edu	37	chr12	64588249	64588249	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgccctccaaacagatgtttCttggtctcccgctgtttctc	7	14	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:64588249C>T	uc001srw.3	-	3	770	c.711G>A	c.(709-711)AAG>AAA	p.K237K	C12orf66_uc009zql.2_Silent_p.K184K	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	237										ovary(1)	1						ACAGATGTTTCTTGGTCTCCC	0.493													0	0	0	0.004482	0	8	66										T	64588249	C	T	64588249	2	4	49	1	0	0	0	0	0	0	0	1	1709	912	32	1		1	C12orf66	12	64588249	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	256	64588249	69263646	102	14004										
DNAH10	196385	broad.mit.edu	37	chr12	124362399	124362399	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tcaaagttccattacatcttCaaccttcgagatctctcacg	4	13	5	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr12:124362399C>T	uc001uft.3	+	47	7987	c.7962C>T	c.(7960-7962)TTC>TTT	p.F2654F		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2654	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTACATCTTCAACCTTCGAG	0.443													0	0	0	0.007413	0	18	259										T	124362399	C	T	124362399	2	4	49	1	0	0	0	0	0	0	0	1	4598	825	29	1		1	DNAH10	12	124362399	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	59774150	124362399	9489496	103	14005										
DNAJC3	5611	broad.mit.edu	37	chr13	96409943	96409943	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aagaaaaggaagcacagtctCaacttataaaatctgatgaa	7	6	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr13:96409943C>T	uc001vmq.2	+	5	547	c.439C>T	c.(439-441)CAA>TAA	p.Q147*	DNAJC3_uc001vmr.2_Intron	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	147					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			AGCACAGTCTCAACTTATAAA	0.343													0	0	0	0.004482	0	9	90										T	96409943	C	T	96409943	4	4	49	1	0	0	0	0	0	1	0	0	4647	827	29	1	457	1	DNAJC3	13	96409943	Nonsense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		96409943	18759935	104	14006										
OR4K1	79544	broad.mit.edu	37	chr14	20404396	20404396	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgatagagctggcttgcatgGatacatatgaaatggaaatt	11	4	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:20404396G>A	uc001vwj.1	+	1	571	c.571G>A	c.(571-573)GAT>AAT	p.D191N		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GGCTTGCATGGATACATATGA	0.443													0	0	0	0.014758	0	5	327										A	20404396	G	A	20404396	3	1	49	1	0	0	0	0	1	0	0	0	11067	1174	41	1	573	1	OR4K1	14	20404396	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		20404396	86945144	105	14007										
MIA2	117153	broad.mit.edu	37	chr14	39716635	39716635	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atctgaatcagaaattgattCagtgccaaagacacagtctg	8	8	4	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:39716635C>T	uc001wux.2	+	4	1051	c.857C>T	c.(856-858)TCA>TTA	p.S286L	MIA2_uc010amy.1_Missense_Mutation_p.S217L	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	286						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		GAAATTGATTCAGTGCCAAAG	0.398													0	0	0	0.001984	0	7	91										T	39716635	C	T	39716635	3	4	49	1	0	0	0	0	1	0	0	0	9564	838	29	1	871	1	MIA2	14	39716635	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	19312239	39716635	67632905	106	14008										
FANCM	57697	broad.mit.edu	37	chr14	45658433	45658433	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cagagcaaacagacatcgctGaatttaaaggatacaatttc	7	8	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:45658433G>C	uc001wwd.3	+	20	5307	c.5208G>C	c.(5206-5208)CTG>CTC	p.L1736L	FANCM_uc010anf.2_Silent_p.L1710L|FANCM_uc001wwe.3_Silent_p.L1272L|FANCM_uc010ang.2_Silent_p.L950L	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1736	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						AGACATCGCTGAATTTAAAGG	0.418								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.010504	0	19	237										C	45658433	G	C	45658433	2	2	49	1	0	0	0	0	0	0	0	1	5671	1277	45	1		1	FANCM	14	45658433	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	5941798	45658433	61691107	107	14009										
POLE2	5427	broad.mit.edu	37	chr14	50118050	50118050	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tttctgcacattttatttacTaagtcttcacggaagacagt	6	8	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:50118050T>C	uc001wwu.2	-	16	1271	c.1257A>G	c.(1255-1257)TTA>TTG	p.L419L	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Silent_p.L133L|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Silent_p.L134L	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	419					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					TTTTATTTACTAAGTCTTCAC	0.323													0	0	0	0.021553	0	5	66										C	50118050	T	C	50118050	2	2	49	1	0	0	0	0	0	0	0	1	12197	1519	53	5		5	POLE2	14	50118050	Silent	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08	4459617	50118050	57231490	108	14010										
PLEKHG3	26030	broad.mit.edu	37	chr14	65198166	65198166	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	agggcacattccgcgtgcatCgcgtgcgcaatgaaaggacc	13	12	0	1	rs145887123		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:65198166C>T	uc001xho.1	+	8	1206	c.937C>T	c.(937-939)CGC>TGC	p.R313C	PLEKHG3_uc001xhn.1_Missense_Mutation_p.R257C|PLEKHG3_uc001xhp.2_Missense_Mutation_p.R313C|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	313	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CCGCGTGCATCGCGTGCGCAA	0.552													0	0	0	0.014758	0	5	67										T	65198166	C	T	65198166	3	4	49	1	0	0	0	0	1	0	0	0	12070	884	31	1	787	1	PLEKHG3	14	65198166	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	15080116	65198166	42151374	109	14011										
NUDT14	256281	broad.mit.edu	37	chr14	105639498	105639498	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gtgcaccacctcaatgagctCaccctcctccaccaggcccc	6	21	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr14:105639498C>T	uc010tyn.1	-	5	643	c.529G>A	c.(529-531)GAG>AAG	p.E177K	NUDT14_uc001yqi.2_RNA	NM_177533	NP_803877	O95848	NUD14_HUMAN	nudix-type motif 14	177	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			skin(1)	1		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCAATGAGCTCACCCTCCTCC	0.622										HNSCC(42;0.11)			0	0	0	0.009096	0	4	34										T	105639498	C	T	105639498	3	4	49	1	0	0	0	0	1	0	0	0	10730	835	29	1	143	1	NUDT14	14	105639498	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	40441332	105639498	1710042	110	14012										
CEP152	22995	broad.mit.edu	37	chr15	49076285	49076285	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgattcctttccagttgtttCacgtgatctttcagacgaga	8	9	3	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:49076285C>T	uc001zwy.2	-	10	1240	c.1206G>A	c.(1204-1206)GTG>GTA	p.V402V	CEP152_uc001zwz.2_Silent_p.V402V|CEP152_uc001zxa.1_Silent_p.V309V	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	402	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCAGTTGTTTCACGTGATCTT	0.333													0	0	0	0.021553	0	5	66										T	49076285	C	T	49076285	2	4	49	1	0	0	0	0	0	0	0	1	3248	813	29	1		1	CEP152	15	49076285	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		49076285	53455107	111	14013										
ZNF609	23060	broad.mit.edu	37	chr15	64968069	64968069	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cggcttaccggcagcagtacGaagaacagcagaaacgccag	12	12	0	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:64968069G>A	uc002ann.2	+	4	3016	c.3016G>A	c.(3016-3018)GAA>AAA	p.E1006K		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	1006						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GCAGCAGTACGAAGAACAGCA	0.562													0	0	0	0.014758	0	4	115										A	64968069	G	A	64968069	3	1	49	1	0	0	0	0	1	0	0	0	18032	1059	37	1	3030	1	ZNF609	15	64968069	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	15891784	64968069	37563323	112	14014										
CORO2B	10391	broad.mit.edu	37	chr15	69018260	69018260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cccagaaggacatccgcattCggcagctccagctggaactg	11	14	0	1	rs146678597		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:69018260C>T	uc002arj.3	+	12	1419	c.1390C>T	c.(1390-1392)CGG>TGG	p.R464W	CORO2B_uc010bic.2_Missense_Mutation_p.R459W|CORO2B_uc002ark.2_Missense_Mutation_p.R231W	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	464	Potential.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CATCCGCATTCGGCAGCTCCA	0.557													0	0	0	0.009096	0	4	52										T	69018260	C	T	69018260	3	4	49	1	0	0	0	0	1	0	0	0	3757	875	31	1	1436	1	CORO2B	15	69018260	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	4050191	69018260	33513132	113	14015										
RLBP1	6017	broad.mit.edu	37	chr15	89758326	89758326	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttcttgactttgccagttctCaatgttgaagagcatgacca	8	9	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr15:89758326C>G	uc002bnl.2	-	6	870	c.490G>C	c.(490-492)GAG>CAG	p.E164Q		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	164	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	TGCCAGTTCTCAATGTTGAAG	0.577													0	0	0	0.00308	0	7	121										G	89758326	C	G	89758326	3	3	49	1	0	0	0	0	1	0	0	0	13388	835	29	1	479	1	RLBP1	15	89758326	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	20740066	89758326	12773066	114	14016										
GLYR1	84656	broad.mit.edu	37	chr16	4882060	4882060	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aggggatttggagcctctctCtgaagagcctgaagacaccc	12	11	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:4882060C>T	uc002cxx.3	-	5	494	c.457G>A	c.(457-459)GAG>AAG	p.E153K	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.E84K|GLYR1_uc002cya.2_Missense_Mutation_p.E153K|GLYR1_uc010uxv.1_Intron	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	153					pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						GAGCCTCTCTCTGAAGAGCCT	0.527													0	0	0	0.010729	0	11	191										T	4882060	C	T	4882060	3	4	49	1	0	0	0	0	1	0	0	0	6483	922	32	1	1252	1	GLYR1	16	4882060	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		4882060	85472693	115	14017										
ADAT1	23536	broad.mit.edu	37	chr16	75654613	75654613	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgccaataatgtccactcatGgtttggctcaggcttcccct	8	13	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75654613G>A	uc002feo.1	-	3	187	c.85C>T	c.(85-87)CAT>TAT	p.H29Y	ADAT1_uc002fep.1_5'UTR	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	29					tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						GTCCACTCATGGTTTGGCTCA	0.522													0	0	0	0.021553	0	6	67										A	75654613	G	A	75654613	3	1	49	1	0	0	0	0	1	0	0	0	284	1348	47	2	1459	2	ADAT1	16	75654613	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	70772553	75654613	14700140	116	14018										
KARS	3735	broad.mit.edu	37	chr16	75669620	75669620	+	Silent	SNP	G	G	T													0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aagaaacttcttatatatgtGatgatcttagagcggatgat							TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75669620G>T	uc002feq.2	-	6	801	c.753C>A	c.(751-753)ATC>ATA	p.I251I	KARS_uc002fer.2_Silent_p.I279I|KARS_uc002fes.2_Silent_p.I95I|KARS_uc010cgz.2_Silent_p.I95I	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	251					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	TTATATATGTGATGATCTTAG	0.443													1	0	7.48243e-07	0.006214	8.30922e-07	9	81										T	75669620	G	T	75669620	2	4	49	1	0	0	0	0	0	0	0	1	7980	1280	45	3		3	KARS	16	75669620	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	15007	75669620	14685133	117	14019	69	2								
KARS	3735	broad.mit.edu	37	chr16	75669626	75669626	+	Missense_Mutation	SNP	C	C	G													0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cttcttatatatgtgatgatCttagagcggatgataaattt							TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr16:75669626C>G	uc002feq.2	-	6	795	c.747G>C	c.(745-747)AAG>AAC	p.K249N	KARS_uc002fer.2_Missense_Mutation_p.K277N|KARS_uc002fes.2_Missense_Mutation_p.K93N|KARS_uc010cgz.2_Missense_Mutation_p.K93N	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	249					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	ATGTGATGATCTTAGAGCGGA	0.433													0	0	0	0.006214	0	9	88										G	75669626	C	G	75669626	3	3	49	1	0	0	0	0	1	0	0	0	7980	912	32	1	1082	1	KARS	16	75669626	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	6	75669626	14685127	118	14020	69	2								
KCTD11	147040	broad.mit.edu	37	chr17	7256592	7256592	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctgctcgccggggaccccatCactatgagctgagctccgtc	11	16	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:7256592C>G	uc002gge.3	+	1	1385	c.331C>G	c.(331-333)CAC>GAC	p.H111D	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	111					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				GGGACCCCATCACTATGAGCT	0.632													0	0	0	0.001984	0	6	59										G	7256592	C	G	7256592	3	3	49	1	0	0	0	0	1	0	0	0	8098	826	29	1	333	1	KCTD11	17	7256592	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		7256592	73938618	119	14021										
PFAS	5198	broad.mit.edu	37	chr17	8168266	8168266	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cagcagtgcgtggggcccctGcaaactcctctggcagatgt	13	13	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:8168266G>A	uc002gkr.2	+	18	2244	c.2103G>A	c.(2101-2103)CTG>CTA	p.L701L	PFAS_uc010vuv.1_Silent_p.L277L|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	701					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGGGGCCCCTGCAAACTCCTC	0.632													0	0	0	0.004672	0	3	8										A	8168266	G	A	8168266	2	1	49	1	0	0	0	0	0	0	0	1	11754	1306	46	2		2	PFAS	17	8168266	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	911674	8168266	73026944	120	14022										
CCL23	6368	broad.mit.edu	37	chr17	34344932	34344932	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	agggcagccacggagaccttCatcctcctggtgggcaggca	14	13	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:34344932C>T	uc002hkt.1	-	1	74	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CCL23_uc002hks.1_Missense_Mutation_p.M1I	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	1					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CGGAGACCTTCATCCTCCTGG	0.577													0	0	0	0.014758	0	4	28										T	34344932	C	T	34344932	3	4	49	1	0	0	0	0	1	0	0	0	2895	826	29	1	426	1	CCL23	17	34344932	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	26176666	34344932	46850278	121	14023										
LRRC46	90506	broad.mit.edu	37	chr17	45912735	45912735	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gcagaataagatccagcaaaTtgagaacctggcttgcatcc	9	10	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:45912735T>C	uc002ima.2	+	4	498	c.242T>C	c.(241-243)ATT>ACT	p.I81T	LRRC46_uc002imb.2_Missense_Mutation_p.I34T	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	81	LRR 2.									ovary(1)	1						ATCCAGCAAATTGAGAACCTG	0.547													0	0	0	0.016522	0	21	195										C	45912735	T	C	45912735	3	2	49	1	0	0	0	0	1	0	0	0	9003	1493	52	5	256	5	LRRC46	17	45912735	Missense_Mutation	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08	11567803	45912735	35282475	122	14024										
LRRC46	90506	broad.mit.edu	37	chr17	45913412	45913412	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgtgcagatgagttcccccaGagccttctcatcctcaacct	7	15	2	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:45913412G>A	uc002ima.2	+	6	652	c.396G>A	c.(394-396)CAG>CAA	p.Q132Q	LRRC46_uc002imb.2_Silent_p.Q85Q	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	132	LRR 4.									ovary(1)	1						AGTTCCCCCAGAGCCTTCTCA	0.453													0	0	0	0.001984	0	7	58										A	45913412	G	A	45913412	2	1	49	1	0	0	0	0	0	0	0	1	9003	933	33	1		1	LRRC46	17	45913412	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	677	45913412	35281798	123	14025										
MSI2	124540	broad.mit.edu	37	chr17	55674294	55674294	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tctgtgagattcatttccatGaaatcaataataaaatggta	6	5	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:55674294G>A	uc002iuz.1	+	8	693	c.520G>A	c.(520-522)GAA>AAA	p.E174K	MSI2_uc010wnm.1_Missense_Mutation_p.E152K|MSI2_uc002iva.2_Missense_Mutation_p.E170K	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	174	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		TCATTTCCATGAAATCAATAA	0.418			T	HOXA9	CML								0	0	0	0.014758	0	5	113										A	55674294	G	A	55674294	3	1	49	1	0	0	0	0	1	0	0	0	9876	1291	45	1	600	1	MSI2	17	55674294	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	9760882	55674294	25520916	124	14026										
PPM1E	22843	broad.mit.edu	37	chr17	57058003	57058003	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ggagtggtgctggagagtttCccactgctttcaatttgggt	14	7	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:57058003C>A	uc002iwx.2	+	7	2006	c.1879C>A	c.(1879-1881)CCC>ACC	p.P627T	PPM1E_uc010ddd.2_Missense_Mutation_p.P390T	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	636					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TGGAGAGTTTCCCACTGCTTT	0.428													1	0	0.000274275	0.004482	0.000301253	9	260										A	57058003	C	A	57058003	3	1	49	1	0	0	0	0	1	0	0	0	12338	855	30	3	1905	3	PPM1E	17	57058003	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	1383709	57058003	24137207	125	14027										
MED13	9969	broad.mit.edu	37	chr17	60028354	60028354	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gatagtagccgatcagtactCtgacccttaaaaagacaaaa	7	9	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:60028354C>G	uc002izo.2	-	28	6200	c.6123G>C	c.(6121-6123)CAG>CAC	p.Q2041H		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2041					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GATCAGTACTCTGACCCTTAA	0.373													0	0	0	0.004482	0	7	98										G	60028354	C	G	60028354	3	3	49	1	0	0	0	0	1	0	0	0	9430	912	32	1	413	1	MED13	17	60028354	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2970351	60028354	21166856	126	14028										
HELZ	9931	broad.mit.edu	37	chr17	65162678	65162678	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tgatcctgtctagtgcatagTgcatttcacagaggggtaat	11	7	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:65162678T>A	uc010wqk.1	-	15	1998	c.1811A>T	c.(1810-1812)CAC>CTC	p.H604L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.H604L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TAGTGCATAGTGCATTTCACA	0.393													0	0	0	0.00308	0	7	154										A	65162678	T	A	65162678	3	1	49	1	0	0	0	0	1	0	0	0	7049	1696	59	5	4093	5	HELZ	17	65162678	Missense_Mutation	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08	5134324	65162678	16032532	127	14029										
BPTF	2186	broad.mit.edu	37	chr17	65889808	65889808	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	attagaaaacaacatcccttCatcctttcttcatcccaact	1	14	3	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:65889808C>T	uc002jgf.2	+	6	2439	c.2378C>T	c.(2377-2379)TCA>TTA	p.S793L	BPTF_uc002jge.2_Missense_Mutation_p.S919L|BPTF_uc010wqm.1_Missense_Mutation_p.S856L	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	919	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AACATCCCTTCATCCTTTCTT	0.368													0	0	0	0.021553	0	4	93										T	65889808	C	T	65889808	3	4	49	1	0	0	0	0	1	0	0	0	1495	838	29	1	2786	1	BPTF	17	65889808	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	727130	65889808	15305402	128	14030										
HGS	9146	broad.mit.edu	37	chr17	79660899	79660899	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccccttctgattctgcctcaGagacagaagtccacgtacac	7	15	3	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr17:79660899G>T	uc002kbg.2	+	11	918	c.841_splice	c.e11-1	p.R281_splice		NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			TTCTGCCTCAGAGACAGAAGT	0.677													1	0	0.00909568	0.009096	0.00972464	4	38										T	79660899	G	T	79660899	5	4	49	1	0	0	0	0	0	0	1	0	7087	956	33	3	882	3	HGS	17	79660899	Splice_Site	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	13771091	79660899	1534311	129	14031										
RNF125	54941	broad.mit.edu	37	chr18	29617078	29617078	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tttttggtctgtttggggtaGattctgccgttcctgtattg	12	6	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr18:29617078G>T	uc002kxf.1	+	2	547	c.165_splice	c.e2-1	p.V55_splice		NM_017831	NP_060301	Q96EQ8	RN125_HUMAN	ring finger protein 125						negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0						GTTTGGGGTAGATTCTGCCGT	0.418													1	0	1.55469e-16	0.01892	1.7655e-16	23	371										T	29617078	G	T	29617078	5	4	49	1	0	0	0	0	0	0	1	0	13434	956	33	3	170	3	RNF125	18	29617078	Splice_Site	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		29617078	48460170	130	14032										
ZFR2	23217	broad.mit.edu	37	chr19	3819052	3819052	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tctccaatgacctgcgcttgTcaccctcttcctctcggcgg	8	17	4	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:3819052T>C	uc002lyw.2	-	12	1934	c.1922A>G	c.(1921-1923)GAC>GGC	p.D641G		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	641						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCTGCGCTTGTCACCCTCTTC	0.682													0	0	0	0.004672	0	2	6										C	3819052	T	C	3819052	3	2	49	1	0	0	0	0	1	0	0	0	17657	1667	58	5	929	5	ZFR2	19	3819052	Missense_Mutation	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08		3819052	55309931	131	14033										
ZNF358	140467	broad.mit.edu	37	chr19	7584139	7584139	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cacgcctgaaatgcggcgctCagtcctggtcaggaacccag	12	14	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:7584139C>T	uc002mgn.2	+	2	181	c.11C>T	c.(10-12)TCA>TTA	p.S4L		NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	4					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						ATGCGGCGCTCAGTCCTGGTC	0.597													0	0	0	0.021553	0	6	81										T	7584139	C	T	7584139	3	4	49	1	0	0	0	0	1	0	0	0	17864	838	29	1	13	1	ZNF358	19	7584139	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	3765087	7584139	51544844	132	14034										
ZNF491	126069	broad.mit.edu	37	chr19	11916920	11916920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aatcttcatgggatattcatCctttaataggaacatcagaa	6	7	4	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:11916920C>T	uc002mso.1	+	3	437	c.152C>T	c.(151-153)TCC>TTC	p.S51F		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	51	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGATATTCATCCTTTAATAGG	0.393													0	0	0	0.00308	0	6	111										T	11916920	C	T	11916920	3	4	49	1	0	0	0	0	1	0	0	0	17939	855	30	1	154	1	ZNF491	19	11916920	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	4332781	11916920	47212063	133	14035										
COPE	11316	broad.mit.edu	37	chr19	19021838	19021838	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	cacggcctggagctcaggggCcgaggagggcttgatctcat	16	11	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:19021838C>T	uc002nkk.2	-	3	274	c.232G>A	c.(232-234)GCC>ACC	p.A78T	COPE_uc002nkl.2_Missense_Mutation_p.A78T|COPE_uc002nkm.2_Missense_Mutation_p.A78T|COPE_uc002nkn.2_Missense_Mutation_p.A78T|HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_Intron	NM_007263	NP_009194	O14579	COPE_HUMAN	epsilon subunit of coatomer protein complex	78					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	binding|structural molecule activity				0						AGCTCAGGGGCCGAGGAGGGC	0.632													0	0	0	0.004482	0	9	156										T	19021838	C	T	19021838	3	4	49	1	0	0	0	0	1	0	0	0	3730	739	26	2	726	2	COPE	19	19021838	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	7104918	19021838	40107145	134	14036										
ZNF429	353088	broad.mit.edu	37	chr19	21720336	21720336	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	caaagcctttaagcagtcctCaaaccttaacagtcataaaa	4	11	2	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:21720336C>G	uc002nqd.1	+	4	1618	c.1481C>G	c.(1480-1482)TCA>TGA	p.S494*	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	494	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAGCAGTCCTCAAACCTTAAC	0.398													0	0	0	0.004482	0	9	59										G	21720336	C	G	21720336	4	3	49	1	0	0	0	0	0	1	0	0	17899	838	29	1	1495	1	ZNF429	19	21720336	Nonsense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2698498	21720336	37408647	135	14037										
ZNF429	353088	broad.mit.edu	37	chr19	21720683	21720683	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	atcggtcctcaagacttactCaacataagaaaattcatact	4	10	3	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:21720683C>G	uc002nqd.1	+	4	1965	c.1828C>G	c.(1828-1830)CAA>GAA	p.Q610E	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	610	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAGACTTACTCAACATAAGAA	0.358													0	0	0	0.001984	0	7	99										G	21720683	C	G	21720683	3	3	49	1	0	0	0	0	1	0	0	0	17899	827	29	1	1842	1	ZNF429	19	21720683	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	347	21720683	37408300	136	14038										
ERF	2077	broad.mit.edu	37	chr19	42754675	42754675	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gctggatctgccttgagccaGgggacgactctggcttgtag	15	10	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:42754675G>C	uc002ote.3	-	2	223	c.65C>G	c.(64-66)CCT>CGT	p.P22R	ERF_uc002otd.3_5'UTR	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	22					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				CCTTGAGCCAGGGGACGACTC	0.642													0	0	0	0.009096	0	4	37										C	42754675	G	C	42754675	3	2	49	1	0	0	0	0	1	0	0	0	5221	1000	35	4	1593	4	ERF	19	42754675	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	21033992	42754675	16374308	137	14039										
ZNF615	284370	broad.mit.edu	37	chr19	52496411	52496411	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gtgaaatcgctgatgttgtaTgaggcatgtcttcttcctga	11	7	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:52496411T>C	uc002pye.1	-	6	2210	c.1918A>G	c.(1918-1920)ATA>GTA	p.I640V	ZNF615_uc002pyf.1_Missense_Mutation_p.I651V|ZNF615_uc002pyg.1_Missense_Mutation_p.I532V|ZNF615_uc002pyh.1_Missense_Mutation_p.I651V|ZNF615_uc010epi.1_Missense_Mutation_p.I647V|ZNF615_uc010ydg.1_Missense_Mutation_p.I645V	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	640	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGATGTTGTATGAGGCATGTC	0.378													0	0	0	0.024245	0	16	308										C	52496411	T	C	52496411	3	2	49	1	0	0	0	0	1	0	0	0	18037	1464	51	5	281	5	ZNF615	19	52496411	Missense_Mutation	SNP	T	TCGA-DK-A1AF-01A-11D-A13W-08	9741736	52496411	6632572	138	14040										
NCR1	9437	broad.mit.edu	37	chr19	55420628	55420628	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gtatgacacacccaccctctCggttcatcctggacccgaag	8	16	2	1	rs142626797		TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr19:55420628C>T	uc002qib.2	+	4	418	c.380C>T	c.(379-381)TCG>TTG	p.S127L	NCR1_uc002qic.2_Missense_Mutation_p.S127L|NCR1_uc002qie.2_Missense_Mutation_p.S127L|NCR1_uc002qid.2_Missense_Mutation_p.S32L|NCR1_uc002qif.2_Missense_Mutation_p.S32L|NCR1_uc010esj.2_Missense_Mutation_p.S20L	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	127	Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CCCACCCTCTCGGTTCATCCT	0.468													0	0	0	0.021553	0	5	88										T	55420628	C	T	55420628	3	4	49	1	0	0	0	0	1	0	0	0	10237	893	31	1	394	1	NCR1	19	55420628	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2924217	55420628	3708355	139	14041										
NTSR1	4923	broad.mit.edu	37	chr20	61391508	61391508	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctggccacactggcctgcctCtgcccggtgtggcggcgcag	15	16	1	0			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr20:61391508C>G	uc002ydf.2	+	4	1517	c.1146C>G	c.(1144-1146)CTC>CTG	p.L382L		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	382	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			TGGCCTGCCTCTGCCCGGTGT	0.627													0	0	0	0.00308	0	3	57										G	61391508	C	G	61391508	2	3	49	1	0	0	0	0	0	0	0	1	10710	900	32	1		1	NTSR1	20	61391508	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		61391508	1634012	140	14042										
SUN2	25777	broad.mit.edu	37	chr22	39141785	39141785	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	accaaagcagggtggaatgtCtgcagcccataggggtagaa	14	8	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr22:39141785C>T	uc003awh.1	-	9	1001	c.717G>A	c.(715-717)CAG>CAA	p.Q239Q	SUN2_uc011anz.1_Silent_p.Q274Q|SUN2_uc011aoa.1_Silent_p.Q228Q|SUN2_uc003awi.1_Silent_p.Q239Q|SUN2_uc010gxq.1_Silent_p.Q260Q|SUN2_uc010gxr.1_Silent_p.Q239Q|SUN2_uc010gxs.1_Silent_p.Q239Q	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	239	Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2						GGTGGAATGTCTGCAGCCCAT	0.617													0	0	0	0.009096	0	4	38										T	39141785	C	T	39141785	2	4	49	1	0	0	0	0	0	0	0	1	15389	912	32	1		1	SUN2	22	39141785	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08		39141785	12162781	141	14043										
CCDC134	79879	broad.mit.edu	37	chr22	42209814	42209814	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttccagaacccatttaaaatCgaccgcacagaggtgagctg	9	11	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chr22:42209814C>T	uc003bbh.1	+	6	661	c.552C>T	c.(550-552)ATC>ATT	p.I184I	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|CCDC134_uc011apg.1_Intron	NM_024821	NP_079097	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134 precursor	184						extracellular region				ovary(2)	2						CATTTAAAATCGACCGCACAG	0.567													0	0	0	0.014758	0	4	86										T	42209814	C	T	42209814	2	4	49	1	0	0	0	0	0	0	0	1	2768	874	31	1		1	CCDC134	22	42209814	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	3068029	42209814	9094752	142	14044										
SLC25A6	293	broad.mit.edu	37	chrX	1508489	1508489	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttgagggcttgagtggggaaGtagcgaatgacgttggcaag	18	4	0	3			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:1508489G>A	uc004cpt.2	-	2	339	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	81	Solcar 1.|Helical; Name=2; (By similarity).				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GAGTGGGGAAGTAGCGAATGA	0.567													0	0	0	0.010729	0	11	189										A	1508489	G	A	1508489	2	1	49	1	0	0	0	0	0	0	0	1	14513	1024	36	2		2	SLC25A6	23	1508489	Silent	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08		1508489	153762071	143	14045										
DDX53	168400	broad.mit.edu	37	chrX	23019978	23019978	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aagatcttgtagtaatggctGagcaatacaagttaaatcaa	8	5	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:23019978G>A	uc004daj.2	+	1	1892	c.1804G>A	c.(1804-1806)GAG>AAG	p.E602K		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	602						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						AGTAATGGCTGAGCAATACAA	0.383													0	0	0	0.009096	0	4	120										A	23019978	G	A	23019978	3	1	49	1	0	0	0	0	1	0	0	0	4371	1291	45	1	1806	1	DDX53	23	23019978	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	21511489	23019978	132250582	144	14046										
FAM47A	158724	broad.mit.edu	37	chrX	34149795	34149795	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	tccagtctcgggaggctctgGgaggagatgggacaccggag	18	9	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:34149795G>A	uc004ddg.2	-	1	634	c.601C>T	c.(601-603)CCA>TCA	p.P201S		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	201	Pro-rich.									ovary(4)|central_nervous_system(1)	5						GGAGGCTCTGGGAGGAGATGG	0.617													0	0	0	0.004672	0	3	64										A	34149795	G	A	34149795	3	1	49	1	0	0	0	0	1	0	0	0	5569	1232	43	2	1778	2	FAM47A	23	34149795	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	11129817	34149795	121120765	145	14047										
KDM6A	7403	broad.mit.edu	37	chrX	44938507	44938507	+	Frame_Shift_Del	DEL	A	A	-													0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	gggatcccactggaacaaagAaaatctggcattgtgaaagt							TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:44938507delA	uc004dge.3	+	20	3430	c.3055delA	c.(3055-3057)AAAfs	p.K1019fs	KDM6A_uc010nhk.2_Frame_Shift_Del_p.K985fs|KDM6A_uc011mkz.1_Frame_Shift_Del_p.K1071fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.K974fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.K1026fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.K723fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.K658fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1019					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGGAACAAAGAAAATCTGGCA	0.398			D|N|F|S		renal|oesophageal SCC|MM													7	106	---	---								-	44938507	A	-	44938507	7	5	49	1	0	1	0	1	0	0	0	0	8137	247	9	0	3133	0	KDM6A	23	44938507	Frame_Shift_Del	DEL	A	TCGA-DK-A1AF-01A-11D-A13W-08	10788712	44938507	110332053	146	14048										
ZNF630	57232	broad.mit.edu	37	chrX	47918817	47918817	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ttctctccagtatggactctCtgatgaacagtgaaaggtga	10	8	2	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:47918817C>G	uc004div.3	-	5	1266	c.1014G>C	c.(1012-1014)CAG>CAC	p.Q338H	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.Q214H	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	338	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						TATGGACTCTCTGATGAACAG	0.428													0	0	0	0.00308	0	8	123										G	47918817	C	G	47918817	3	3	49	1	0	0	0	0	1	0	0	0	18051	912	32	1	963	1	ZNF630	23	47918817	Missense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	2980310	47918817	107351743	147	14049										
WDR13	64743	broad.mit.edu	37	chrX	48460204	48460204	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aagcacaacgtgcatgtcatGaacatctccacaggcaagaa	8	11	2	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:48460204G>A	uc004dkh.1	+	7	1011	c.864G>A	c.(862-864)ATG>ATA	p.M288I	WDR13_uc010nif.1_Missense_Mutation_p.M166I|WDR13_uc004dki.1_Missense_Mutation_p.M196I|WDR13_uc004dkj.1_Missense_Mutation_p.M288I|WDR13_uc004dkk.1_Missense_Mutation_p.M196I|WDR13_uc004dkl.3_Missense_Mutation_p.M196I	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	288						cytoplasm|nucleus				ovary(2)	2						TGCATGTCATGAACATCTCCA	0.602													0	0	0	0.009096	0	3	32										A	48460204	G	A	48460204	3	1	49	1	0	0	0	0	1	0	0	0	17272	1290	45	1	886	1	WDR13	23	48460204	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	541387	48460204	106810356	148	14050										
USP51	158880	broad.mit.edu	37	chrX	55514287	55514287	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ccaagattgattagccctctCaggcctacagtatagactga	8	11	1	4			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:55514287C>G	uc004dun.1	-	2	1165	c.1086G>C	c.(1084-1086)CTG>CTC	p.L362L	USP51_uc011moo.1_Silent_p.L66L	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	362					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TTAGCCCTCTCAGGCCTACAG	0.403													0	0	0	0.020292	0	15	223										G	55514287	C	G	55514287	2	3	49	1	0	0	0	0	0	0	0	1	17080	813	29	1		1	USP51	23	55514287	Silent	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	7054083	55514287	99756273	149	14051										
ATRX	546	broad.mit.edu	37	chrX	76939952	76939952	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	aggctctgggtgacaaatgtAgcaataccattggttgtttt	11	6	1	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:76939952A>T	uc004ecp.3	-	9	1028	c.796T>A	c.(796-798)TAC>AAC	p.Y266N	ATRX_uc004ecq.3_Missense_Mutation_p.Y228N|ATRX_uc004eco.3_Missense_Mutation_p.Y51N|ATRX_uc004ecr.2_Missense_Mutation_p.Y227N|ATRX_uc010nlx.1_Missense_Mutation_p.Y266N|ATRX_uc010nly.1_Missense_Mutation_p.Y211N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	266	ADD.|PHD-type; atypical.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGACAAATGTAGCAATACCAT	0.388			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.001984	0	7	448										T	76939952	A	T	76939952	3	4	49	1	0	0	0	0	1	0	0	0	1208	420	15	5	6790	5	ATRX	23	76939952	Missense_Mutation	SNP	A	TCGA-DK-A1AF-01A-11D-A13W-08	21425665	76939952	78330608	150	14052										
STAG2	10735	broad.mit.edu	37	chrX	123179197	123179197	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	actcacaagtcagagcatttCgacatacaagcaccctggca	7	13	2	1			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:123179197C>T	uc004etz.3	+	7	985	c.646C>T	c.(646-648)CGA>TGA	p.R216*	STAG2_uc004eua.2_Nonsense_Mutation_p.R216*|STAG2_uc004eub.2_Nonsense_Mutation_p.R216*|STAG2_uc004euc.2_Nonsense_Mutation_p.R216*|STAG2_uc004eud.2_Nonsense_Mutation_p.R216*|STAG2_uc004eue.2_Nonsense_Mutation_p.R216*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	216					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAGAGCATTTCGACATACAAG	0.343													0	0	0	0.010504	0	20	335										T	123179197	C	T	123179197	4	4	49	1	0	0	0	0	0	1	0	0	15242	876	31	1	668	1	STAG2	23	123179197	Nonsense_Mutation	SNP	C	TCGA-DK-A1AF-01A-11D-A13W-08	46239245	123179197	32091363	151	14053										
F8	2157	broad.mit.edu	37	chrX	154197729	154197729	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.582781456953642	88	1.11963900535317e-32	3.69888027562446	5.06074074074074	2.96931216931217	0.656450568011918	0.768815980554499	64	ctggcgatggttcctcacaaGaaatgtgtgaccttcgagga	12	9	1	2			TCGA-DK-A1AF-01A-11D-A13W-08	TCGA-DK-A1AF-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fbdcd7f9-1901-4e90-8e3c-71b05dc96da1	303b1fd2-d7a6-4166-a8a9-6f4677850cdd	g.chrX:154197729G>A	uc004fmt.2	-	7	1057	c.886C>T	c.(886-888)CTT>TTT	p.L296F		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	296	Plastocyanin-like 2.|F5/8 type A 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCTCACAAGAAATGTGTGA	0.463													0	0	0	0.028581	0	12	195										A	154197729	G	A	154197729	3	1	49	1	0	0	0	0	1	0	0	0	5350	942	33	1	6277	1	F8	23	154197729	Missense_Mutation	SNP	G	TCGA-DK-A1AF-01A-11D-A13W-08	31018532	154197729	1072831	152	14054										
PANK4	55229	broad.mit.edu	37	chr1	2440291	2440291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggcagctgcagcgcctcactCggctgggacctcgtacttga	13	14	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:2440291C>T	uc001ajm.1	-	19	2326	c.2317G>A	c.(2317-2319)GAG>AAG	p.E773K	PANK4_uc010nza.1_Missense_Mutation_p.E734K	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	773					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GCGCCTCACTCGGCTGGGACC	0.567													0	0	0	0.00632	0	23	18										T	2440291	C	T	2440291	3	4	50	1	0	0	0	0	1	0	0	0	11419	893	31	1	8	1	PANK4	1	2440291	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		2440291	246810330	1	14055										
CASZ1	54897	broad.mit.edu	37	chr1	10714109	10714109	+	Frame_Shift_Del	DEL	G	G	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcagccggcgcggatgcagtGgaagtggttggtagccttgc							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:10714109delG	uc001aro.2	-	11	2325	c.2005delC	c.(2005-2007)CACfs	p.H669fs	CASZ1_uc001arp.1_Frame_Shift_Del_p.H669fs|CASZ1_uc009vmx.2_Frame_Shift_Del_p.H693fs	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	669	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGGATGCAGTGGAAGTGGTTG	0.607																		12	249	---	---								-	10714109	G	-	10714109	7	5	50	1	0	1	0	1	0	0	0	0	2685	1348	47	0	3322	0	CASZ1	1	10714109	Frame_Shift_Del	DEL	G	TCGA-DK-A1AG-01A-11D-A13W-08	8273818	10714109	238536512	2	14056										
FBXO44	93611	broad.mit.edu	37	chr1	11721281	11721282	+	Frame_Shift_Ins	INS	-	-	C													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tactgggccggctggtacggINScccgagggtcaccaacagca							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:11721281_11721282insC	uc001asm.2	+	6	845_846	c.719_720insC	c.(718-720)GGCfs	p.G240fs	FBXO44_uc001ask.2_Frame_Shift_Ins_p.R198fs|FBXO44_uc001asl.2_Frame_Shift_Ins_p.G240fs|FBXO44_uc001asn.2_Frame_Shift_Ins_p.R198fs|FBXO44_uc010oar.1_Frame_Shift_Ins_p.R230fs|FBXO44_uc010oas.1_Frame_Shift_Ins_p.G100fs|FBXO6_uc001aso.2_5'Flank	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	240	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GGCTGGTACGGCCCGAGGGTCA	0.634																		7	275	---	---								C	11721282	-	C	11721281	7	5	50	1	0	1	1	0	0	0	0	0	5753	1203	42	0	737	0	FBXO44	1	11721281	Frame_Shift_Ins	INS	-	TCGA-DK-A1AG-01A-11D-A13W-08	1007172	11721281	237529340	3	14057										
MYOM3	127294	broad.mit.edu	37	chr1	24419480	24419480	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgttcccggggtccgaagggCgagggcacccggaccatgta	16	12	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:24419480C>T	uc001bin.3	-	10	1210	c.1047G>A	c.(1045-1047)TCG>TCA	p.S349S	MYOM3_uc001bim.3_Silent_p.S6S|MYOM3_uc001bio.2_Silent_p.S349S|MYOM3_uc001bip.1_Silent_p.S6S	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	349	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GTCCGAAGGGCGAGGGCACCC	0.458													0	0	0	0.01892	0	25	22										T	24419480	C	T	24419480	2	4	50	1	0	0	0	0	0	0	0	1	10093	755	27	2		2	MYOM3	1	24419480	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	12698199	24419480	224831141	4	14058										
GPN2	54707	broad.mit.edu	37	chr1	27210712	27210712	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggcttccaagcttcgctgctCttgggctctgaaacagtatc	10	12	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:27210712C>G	uc001bnd.1	-	4	1081	c.799G>C	c.(799-801)GAG>CAG	p.E267Q		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	267							GTP binding				0						CTTCGCTGCTCTTGGGCTCTG	0.537													0	0	0	0.00632	0	29	34										G	27210712	C	G	27210712	3	3	50	1	0	0	0	0	1	0	0	0	6618	922	32	1	141	1	GPN2	1	27210712	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	2791232	27210712	222039909	5	14059										
EBNA1BP2	10969	broad.mit.edu	37	chr1	43630462	43630462	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	acttctggtttttataccgtCgtttagcactgggcctggaa	10	9	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:43630462C>T	uc001cin.2	-	8	919	c.722G>A	c.(721-723)CGA>CAA	p.R241Q	EBNA1BP2_uc001cio.2_Missense_Mutation_p.R296Q|EBNA1BP2_uc001cim.2_Missense_Mutation_p.R136Q|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.R296Q	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	241					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTTATACCGTCGTTTAGCACT	0.468													0	0	0	0.00499	0	17	100										T	43630462	C	T	43630462	3	4	50	1	0	0	0	0	1	0	0	0	4885	884	31	1	206	1	EBNA1BP2	1	43630462	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	16419750	43630462	205620159	6	14060										
C1orf54	79630	broad.mit.edu	37	chr1	150248969	150248969	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	taacagaagcaatagagactAccattagtcttgaaacagca	7	8	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:150248969A>G	uc001eud.2	+	4	267	c.229A>G	c.(229-231)ACC>GCC	p.T77A	C1orf54_uc001euc.2_Missense_Mutation_p.T77A|C1orf54_uc001eue.2_Missense_Mutation_p.T77A|C1orf54_uc001euf.2_Missense_Mutation_p.T77A|C1orf54_uc001eug.2_Missense_Mutation_p.T77A	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	77						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AATAGAGACTACCATTAGTCT	0.453													0	0	0	0.007835	0	39	57										G	150248969	A	G	150248969	3	3	50	1	0	0	0	0	1	0	0	0	2046	391	14	5	243	5	C1orf54	1	150248969	Missense_Mutation	SNP	A	TCGA-DK-A1AG-01A-11D-A13W-08	106618507	150248969	99001652	7	14061										
RORC	6097	broad.mit.edu	37	chr1	151785462	151785462	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggctgtgtagagggcaatctCatcctcggaaaagtgcaagg	14	8	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:151785462C>T	uc001ezh.2	-	9	1354	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	RORC_uc001ezg.2_Missense_Mutation_p.E395K|RORC_uc010pdo.1_Missense_Mutation_p.E470K|RORC_uc010pdp.1_Missense_Mutation_p.E404K	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	416	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGGCAATCTCATCCTCGGAA	0.517													0	0	0	0.00632	0	28	50										T	151785462	C	T	151785462	3	4	50	1	0	0	0	0	1	0	0	0	13530	835	29	1	322	1	RORC	1	151785462	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1536493	151785462	97465159	8	14062										
RUSC1	23623	broad.mit.edu	37	chr1	155292628	155292628	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cgacaccgagctccccccctCggggtcgccgggcggctcct	13	20	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:155292628C>T	uc001fkj.2	+	2	1293	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.S355L|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	355						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CTCCCCCCCTCGGGGTCGCCG	0.701													0	0	0	0.01441	0	52	47										T	155292628	C	T	155292628	3	4	50	1	0	0	0	0	1	0	0	0	13750	893	31	1	1066	1	RUSC1	1	155292628	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	3507166	155292628	93957993	9	14063										
TMCC2	9911	broad.mit.edu	37	chr1	205240950	205240950	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgcccctgcaggaggccgtgGagtcctgcctgacccgggtc	15	15	0	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:205240950G>T	uc001hbz.1	+	6	2272	c.1828G>T	c.(1828-1830)GAG>TAG	p.E610*	TMCC2_uc010prf.1_Nonsense_Mutation_p.E532*|TMCC2_uc001hca.2_Nonsense_Mutation_p.E385*|TMCC2_uc001hcb.1_Nonsense_Mutation_p.E370*|TMCC2_uc001hcc.1_Nonsense_Mutation_p.E231*|TMCC2_uc001hcd.2_3'UTR	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	610	Potential.					integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GGAGGCCGTGGAGTCCTGCCT	0.647													1	0	7.81431e-29	0.01441	8.2185e-29	80	94										T	205240950	G	T	205240950	4	4	50	1	0	0	0	0	0	1	0	0	15990	1175	41	3	1846	3	TMCC2	1	205240950	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	49948322	205240950	44009671	10	14064										
LYST	1130	broad.mit.edu	37	chr1	235966211	235966211	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cttcaatgatattttaccatCatcctgggtttcgccatctt	5	11	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:235966211C>T	uc001hxj.2	-	8	3884	c.3709G>A	c.(3709-3711)GAT>AAT	p.D1237N	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.D1237N	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1237					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATTTTACCATCATCCTGGGTT	0.313									Chediak-Higashi_syndrome				0	0	0	0.014758	0	4	35										T	235966211	C	T	235966211	3	4	50	1	0	0	0	0	1	0	0	0	9128	826	29	1	7880	1	LYST	1	235966211	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	30725261	235966211	13284410	11	14065										
AHCTF1	25909	broad.mit.edu	37	chr1	247057966	247057966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	acctctaatacttacatagtCtgtcaaattcctcttttgtg	4	10	4	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr1:247057966C>G	uc001ibu.1	-	13	1806	c.1799G>C	c.(1798-1800)AGA>ACA	p.R600T	AHCTF1_uc001ibv.1_Missense_Mutation_p.R609T|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	600	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTACATAGTCTGTCAAATTC	0.303													0	0	0	0.021523	0	21	22										G	247057966	C	G	247057966	3	3	50	1	0	0	0	0	1	0	0	0	408	913	32	1	5093	1	AHCTF1	1	247057966	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	11091755	247057966	2192655	12	14066										
EMILIN1	11117	broad.mit.edu	37	chr2	27301966	27301966	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	accctctggagctgctacctCtgctgcctgctgacggcagc	11	16	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:27301966C>G	uc002rii.3	+	1	461	c.33C>G	c.(31-33)CTC>CTG	p.L11L	EMILIN1_uc010eyq.1_Silent_p.L11L	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	11					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGCTACCTCTGCTGCCTGC	0.726													0	0	0	0.010504	0	15	15										G	27301966	C	G	27301966	2	3	50	1	0	0	0	0	0	0	0	1	5093	900	32	1		1	EMILIN1	2	27301966	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		27301966	215897407	13	14067										
EMILIN1	11117	broad.mit.edu	37	chr2	27302012	27302012	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gggccgccagctaccctcctCgaggtttcagcctctacaca	9	17	2	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:27302012C>G	uc002rii.3	+	1	507	c.79C>G	c.(79-81)CGA>GGA	p.R27G	EMILIN1_uc010eyq.1_Missense_Mutation_p.R27G	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	27					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTACCCTCCTCGAGGTTTCAG	0.716													0	0	0	0.006122	0	16	14										G	27302012	C	G	27302012	3	3	50	1	0	0	0	0	1	0	0	0	5093	876	31	1	81	1	EMILIN1	2	27302012	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	46	27302012	215897361	14	14068										
REEP1	65055	broad.mit.edu	37	chr2	86459784	86459784	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ctcagaagcactcctggacaTcttaggctggccgtgtttgc	11	12	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:86459784T>A	uc002srh.3	-	6	703	c.559A>T	c.(559-561)ATG>TTG	p.M187L	REEP1_uc010ytg.1_Missense_Mutation_p.M166L|REEP1_uc010yth.1_Missense_Mutation_p.M160L|REEP1_uc010yti.1_Missense_Mutation_p.R108S	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	187					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0						CTCCTGGACATCTTAGGCTGG	0.647													0	0	0	0.027356	0	25	31										A	86459784	T	A	86459784	3	1	50	1	0	0	0	0	1	0	0	0	13204	1435	50	5	115	5	REEP1	2	86459784	Missense_Mutation	SNP	T	TCGA-DK-A1AG-01A-11D-A13W-08	59157772	86459784	156739589	15	14069										
SH3RF3	344558	broad.mit.edu	37	chr2	110015235	110015235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcaagaagaacaccaagaaaCgccactccttcaccgcgctc	7	16	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:110015235C>T	uc010ywt.1	+	4	1135	c.1135C>T	c.(1135-1137)CGC>TGC	p.R379C		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	379							zinc ion binding			ovary(1)	1						CACCAAGAAACGCCACTCCTT	0.597													0	0	0	0.024245	0	16	40										T	110015235	C	T	110015235	3	4	50	1	0	0	0	0	1	0	0	0	14260	536	19	2	1149	2	SH3RF3	2	110015235	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	23555451	110015235	133184138	16	14070										
CCDC93	54520	broad.mit.edu	37	chr2	118731529	118731529	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgcttgatctcagcagagcaGagtcccacaatctggcccac	9	14	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:118731529G>C	uc002tlj.2	-	11	969	c.843C>G	c.(841-843)CTC>CTG	p.L281L	CCDC93_uc010fld.1_Silent_p.L281L	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	281	Potential.									large_intestine(1)|ovary(1)	2						CAGCAGAGCAGAGTCCCACAA	0.542													0	0	0	0.016723	0	11	17										C	118731529	G	C	118731529	2	2	50	1	0	0	0	0	0	0	0	1	2872	929	33	1		1	CCDC93	2	118731529	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	8716294	118731529	124467844	17	14071										
UBXN4	23190	broad.mit.edu	37	chr2	136519444	136519444	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	agcctagtggatgctcagatCagagacctgcagaggacctc	12	11	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:136519444C>T	uc002tur.2	+	6	876	c.565C>T	c.(565-567)CAG>TAG	p.Q189*	UBXN4_uc002tus.2_Intron	NM_014607	NP_055422	Q92575	UBXN4_HUMAN	UBX domain containing 2	189	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2						ATGCTCAGATCAGAGACCTGC	0.388													0	0	0	0.016522	0	19	26										T	136519444	C	T	136519444	4	4	50	1	0	0	0	0	0	1	0	0	16913	827	29	1	587	1	UBXN4	2	136519444	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	17787915	136519444	106679929	18	14072										
FAP	2191	broad.mit.edu	37	chr2	163029727	163029727	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ctgctcttgccatcacagttGaattctggaaaagagaaaaa	8	8	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:163029727G>C	uc002ucd.2	-	24	2247	c.2039C>G	c.(2038-2040)TCA>TGA	p.S680*	FAP_uc010fpc.2_Nonsense_Mutation_p.S229*|FAP_uc010zct.1_Nonsense_Mutation_p.S655*|FAP_uc010fpd.2_Nonsense_Mutation_p.S159*	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	680	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						CATCACAGTTGAATTCTGGAA	0.348													0	0	0	0.019004	0	34	55										C	163029727	G	C	163029727	4	2	50	1	0	0	0	0	0	1	0	0	5673	1294	45	1	255	1	FAP	2	163029727	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	26510283	163029727	80169646	19	14073										
UBR3	130507	broad.mit.edu	37	chr2	170917627	170917627	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagtcttacgaagtattactGagctttgtgataagtgaact	9	5	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr2:170917627G>A	uc010zdi.1	+	34	4824	c.4824G>A	c.(4822-4824)CTG>CTA	p.L1608L	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Silent_p.L429L|UBR3_uc002uft.3_Silent_p.L465L|UBR3_uc010zdj.1_Silent_p.L299L|UBR3_uc002ufu.3_Silent_p.L114L	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1608					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						AAGTATTACTGAGCTTTGTGA	0.318													0	0	0	0.004482	0	8	90										A	170917627	G	A	170917627	2	1	50	1	0	0	0	0	0	0	0	1	16900	1277	45	1		1	UBR3	2	170917627	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	7887900	170917627	72281746	20	14074										
CAND2	23066	broad.mit.edu	37	chr3	12858614	12858614	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gacccaggcccagccagcctCtttggtggaggtcagtggcc	14	14	2	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr3:12858614C>T	uc003bxk.2	+	10	2232	c.2183C>T	c.(2182-2184)TCT>TTT	p.S728F	CAND2_uc003bxj.2_Missense_Mutation_p.S635F	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	728					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CAGCCAGCCTCTTTGGTGGAG	0.652													0	0	0	0.01441	0	65	81										T	12858614	C	T	12858614	3	4	50	1	0	0	0	0	1	0	0	0	2616	913	32	1	2221	1	CAND2	3	12858614	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		12858614	185163816	21	14075										
CBLB	868	broad.mit.edu	37	chr3	105400433	105400433	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtggtaatggcacgggatcaGaggctgaatcaaaaacatct	12	7	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr3:105400433G>C	uc003dwc.2	-	16	2640	c.2318C>G	c.(2317-2319)TCT>TGT	p.S773C	CBLB_uc003dwa.2_Intron|CBLB_uc011bhi.1_Intron|CBLB_uc003dwd.1_Missense_Mutation_p.S773C|CBLB_uc003dwe.1_3'UTR	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	773	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						CACGGGATCAGAGGCTGAATC	0.423			Mis S		AML								0	0	0	0.025465	0	36	74										C	105400433	G	C	105400433	3	2	50	1	0	0	0	0	1	0	0	0	2701	942	33	1	646	1	CBLB	3	105400433	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	92541819	105400433	92621997	22	14076										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.00632	0	27	24										A	178936091	G	A	178936091	3	1	50	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	73535658	178936091	19086339	23	14077										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq;WGS			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	25	6										G	1803568	C	G	1803568	3	3	50	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		1803568	189350708	24	14078										
LRPAP1	4043	broad.mit.edu	37	chr4	3516518	3516518	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtccgcccctccagcagggcGtgcttctcgcggctgcggct	14	17	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:3516518G>A	uc003ghi.2	-	7	1057	c.972C>T	c.(970-972)CAC>CAT	p.H324H		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	324	LDL receptor binding (Potential).				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		CCAGCAGGGCGTGCTTCTCGC	0.672													0	0	0	0.012213	0	21	153										A	3516518	G	A	3516518	2	1	50	1	0	0	0	0	0	0	0	1	8964	1136	40	2		2	LRPAP1	4	3516518	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	1712950	3516518	187637758	25	14079										
SH3TC1	54436	broad.mit.edu	37	chr4	8224616	8224616	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagaaaagtcattcttcagcGagggctgcttttctgaggag	12	7	4	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:8224616G>A	uc003gkv.3	+	10	1263	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	SH3TC1_uc003gkw.3_Missense_Mutation_p.E312K|SH3TC1_uc003gkx.3_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	388							binding			large_intestine(2)|pancreas(1)	3						ATTCTTCAGCGAGGGCTGCTT	0.488													0	0	0	0.023175	0	40	53										A	8224616	G	A	8224616	3	1	50	1	0	0	0	0	1	0	0	0	14261	1059	37	1	1196	1	SH3TC1	4	8224616	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	4708098	8224616	182929660	26	14080										
SPATA18	132671	broad.mit.edu	37	chr4	52945953	52945953	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caatcccaagatttcattccCtcctgtcgttgacttttgcc	5	14	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:52945953C>T	uc003gzl.2	+	9	1501	c.1223C>T	c.(1222-1224)CCT>CTT	p.P408L	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.P376L|SPATA18_uc003gzk.1_Missense_Mutation_p.P408L	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	408					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			ATTTCATTCCCTCCTGTCGTT	0.438													0	0	0	0.01441	0	128	159										T	52945953	C	T	52945953	3	4	50	1	0	0	0	0	1	0	0	0	15002	681	24	2	1257	2	SPATA18	4	52945953	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	44721337	52945953	138208323	27	14081										
FRAS1	80144	broad.mit.edu	37	chr4	79403578	79403578	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tcttggatgacactcagtatCcggtaattgaaggactggag	12	7	2	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:79403578C>G	uc003hlb.2	+	58	9081	c.8641C>G	c.(8641-8643)CCG>GCG	p.P2881A		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2876	Calx-beta 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CACTCAGTATCCGGTAATTGA	0.453													0	0	0	0.01441	0	93	130										G	79403578	C	G	79403578	3	3	50	1	0	0	0	0	1	0	0	0	6042	855	30	1	8946	1	FRAS1	4	79403578	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	26457625	79403578	111750698	28	14082										
EGF	1950	broad.mit.edu	37	chr4	110866376	110866376	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tttgtaccacttggtgaactGaaagtagtgcatccacttgc	9	9	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:110866376G>A	uc003hzy.3	+	5	1337	c.885G>A	c.(883-885)CTG>CTA	p.L295L	EGF_uc011cfu.1_Silent_p.L295L|EGF_uc011cfv.1_Silent_p.L295L	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	295	Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTGGTGAACTGAAAGTAGTGC	0.458													0	0	0	0.00499	0	15	19										A	110866376	G	A	110866376	2	1	50	1	0	0	0	0	0	0	0	1	4962	1277	45	1		1	EGF	4	110866376	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	31462798	110866376	80287900	29	14083										
SEC24D	9871	broad.mit.edu	37	chr4	119736285	119736285	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cctgggtaagacagttgtgcGcctgccatctggggaccaga	14	11	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:119736285G>A	uc003ici.3	-	6	971	c.699C>T	c.(697-699)GGC>GGT	p.G233G	SEC24D_uc003icj.3_Silent_p.G234G|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	233	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						ACAGTTGTGCGCCTGCCATCT	0.512													0	0	0	0.009718	0	45	38										A	119736285	G	A	119736285	2	1	50	1	0	0	0	0	0	0	0	1	13997	1074	38	2		2	SEC24D	4	119736285	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	8869909	119736285	71417991	30	14084										
TBC1D9	23158	broad.mit.edu	37	chr4	141578845	141578845	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aaaggcatcacactgagaaaTagtgtgaggaaccaagacag	11	7	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:141578845T>C	uc010ioj.2	-	12	2315	c.2043A>G	c.(2041-2043)CTA>CTG	p.L681L		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	681	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CACTGAGAAATAGTGTGAGGA	0.483													0	0	0	0.01441	0	61	60										C	141578845	T	C	141578845	2	2	50	1	0	0	0	0	0	0	0	1	15624	1393	49	5		5	TBC1D9	4	141578845	Silent	SNP	T	TCGA-DK-A1AG-01A-11D-A13W-08	21842560	141578845	49575431	31	14085										
ADAM29	11086	broad.mit.edu	37	chr4	175898670	175898670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tggaggtagtgttgacagtgGcccaccccctaagagaaaga	13	9	0	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:175898670G>A	uc003iuc.2	+	5	2664	c.1994G>A	c.(1993-1995)GGC>GAC	p.G665D	ADAM29_uc003iud.2_Missense_Mutation_p.G665D|ADAM29_uc010irr.2_Missense_Mutation_p.G665D|ADAM29_uc011cki.1_Missense_Mutation_p.G665D	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	665	Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GTTGACAGTGGCCCACCCCCT	0.393													0	0	0	0.008361	0	29	27										A	175898670	G	A	175898670	3	1	50	1	0	0	0	0	1	0	0	0	247	1203	42	2	1996	2	ADAM29	4	175898670	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	34319825	175898670	15255606	32	14086										
FAT1	2195	broad.mit.edu	37	chr4	187541182	187541182	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tctgcaatctctgcactgtaGaaaggtttttcaaacacagg	8	9	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr4:187541182G>C	uc003izf.2	-	10	6746	c.6558C>G	c.(6556-6558)TTC>TTG	p.F2186L		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2186	Extracellular (Potential).|Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTGCACTGTAGAAAGGTTTTT	0.512										HNSCC(5;0.00058)			0	0	0	0.01441	0	62	72										C	187541182	G	C	187541182	3	2	50	1	0	0	0	0	1	0	0	0	5689	933	33	1	7280	1	FAT1	4	187541182	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	11642512	187541182	3613094	33	14087										
EXOC3	11336	broad.mit.edu	37	chr5	454125	454125	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gaagacctggaagccaatgaGatcgtgagcctcttgacgtg	13	9	1	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:454125G>C	uc003jba.2	+	4	1133	c.1005G>C	c.(1003-1005)GAG>GAC	p.E335D		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	346					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AAGCCAATGAGATCGTGAGCC	0.542													0	0	0	0.020292	0	11	19										C	454125	G	C	454125	3	2	50	1	0	0	0	0	1	0	0	0	5303	933	33	1	1015	1	EXOC3	5	454125	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		454125	180461135	34	14088										
PRLR	5618	broad.mit.edu	37	chr5	35065622	35065622	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	agtctcagaatggaagctttCtacctccctctgctgggttg	10	11	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:35065622C>G	uc003jjm.2	-	10	1968	c.1438G>C	c.(1438-1440)GAA>CAA	p.E480Q	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Missense_Mutation_p.E379Q	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	480	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGGAAGCTTTCTACCTCCCTC	0.498													0	0	0	0.01441	0	52	77										G	35065622	C	G	35065622	3	3	50	1	0	0	0	0	1	0	0	0	12531	922	32	1	434	1	PRLR	5	35065622	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	34611497	35065622	145849638	35	14089										
SLCO4C1	353189	broad.mit.edu	37	chr5	101585389	101585389	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgaacagcctgcaaagcaggGagaaaaatattggactccat	10	8	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:101585389G>A	uc003knm.2	-	9	1860	c.1573C>T	c.(1573-1575)CCC>TCC	p.P525S		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	525	Kazal-like.|Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GCAAAGCAGGGAGAAAAATAT	0.418													0	0	0	0.00499	0	18	27										A	101585389	G	A	101585389	3	1	50	1	0	0	0	0	1	0	0	0	14730	1174	41	1	621	1	SLCO4C1	5	101585389	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	66519767	101585389	79329871	36	14090										
PCDHA11	56138	broad.mit.edu	37	chr5	140249093	140249093	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aacccgccggtgttctcgctCagagaacaaaagctgctgat	10	12	2	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:140249093C>G	uc003lia.2	+	1	1263	c.405C>G	c.(403-405)CTC>CTG	p.L135L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.L135L	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	135	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTCTCGCTCAGAGAACAAA	0.517													0	0	0	0.01441	0	202	261										G	140249093	C	G	140249093	2	3	50	1	0	0	0	0	0	0	0	1	11521	813	29	1		1	PCDHA11	5	140249093	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	38663704	140249093	40666167	37	14091										
ADAM19	8728	broad.mit.edu	37	chr5	156946865	156946865	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	accctgcgaggtcgcttcttGgtctgttgtgtaaactgaag	12	9	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:156946865G>T	uc003lwz.2	-	6	646	c.582C>A	c.(580-582)ACC>ACA	p.T194T	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Silent_p.T125T	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	194					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCGCTTCTTGGTCTGTTGTG	0.542													1	0	3.07002e-29	0.01441	3.24747e-29	53	91										T	156946865	G	T	156946865	2	4	50	1	0	0	0	0	0	0	0	1	240	1335	47	4		4	ADAM19	5	156946865	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	16697772	156946865	23968395	38	14092										
PANK3	79646	broad.mit.edu	37	chr5	167986163	167986163	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagacaactctgtttattttCtaaaagaaaagaacaaagaa	5	5	2	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:167986163C>T	uc003lzz.1	-	6	1237	c.937_splice	c.e6-1	p.K313_splice	MIR103-1AS_hsa-mir-103-1-as|MI0007261_5'Flank	NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3						coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TGTTTATTTTCTAAAAGAAAA	0.249													0	0	0	0.00632	0	29	19										T	167986163	C	T	167986163	5	4	50	1	0	0	0	0	0	0	1	0	11418	927	32	1	184	1	PANK3	5	167986163	Splice_Site	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	11039298	167986163	12929097	39	14093										
OR2Y1	134083	broad.mit.edu	37	chr5	180167034	180167034	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caccaaaatgaagccatcttCaaaactggtgttgaaacttc	6	10	2	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr5:180167034C>G	uc003mmf.1	-	1	25	c.25G>C	c.(25-27)GAA>CAA	p.E9Q		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGCCATCTTCAAAACTGGTG	0.438													0	0	0	0.01892	0	23	37										G	180167034	C	G	180167034	3	3	50	1	0	0	0	0	1	0	0	0	11035	835	29	1	914	1	OR2Y1	5	180167034	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	12180871	180167034	748226	40	14094										
SERPINB6	5269	broad.mit.edu	37	chr6	2954877	2954877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtgttttctggacttctctaCggcgctgataaagtcaagct	10	9	3	1	rs146252067		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:2954877C>T	uc003muk.2	-	3	2374	c.379G>A	c.(379-381)GTA>ATA	p.V127I	SERPINB6_uc003mui.2_Missense_Mutation_p.V10I|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.V127I|SERPINB6_uc003mum.2_Missense_Mutation_p.V127I|SERPINB6_uc003mun.2_Missense_Mutation_p.V127I|SERPINB6_uc003muo.2_Missense_Mutation_p.V127I	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	127					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	GACTTCTCTACGGCGCTGATA	0.393													0	0	0	0.01441	0	49	74										T	2954877	C	T	2954877	3	4	50	1	0	0	0	0	1	0	0	0	14105	536	19	2	767	2	SERPINB6	6	2954877	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		2954877	168160190	41	14095										
GCNT2	2651	broad.mit.edu	37	chr6	10621627	10621627	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcatcctggactggaaacctCagagctataaagtggagtga	12	8	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:10621627C>T	uc010joo.2	+	4	1520	c.969C>T	c.(967-969)CTC>CTT	p.L323L	GCNT2_uc010jol.2_Silent_p.L37L|GCNT2_uc010jom.2_RNA|GCNT2_uc010jop.2_RNA|GCNT2_uc003mza.2_RNA|GCNT2_uc003mzc.3_Silent_p.L322L|GCNT2_uc003mzd.2_Silent_p.L321L|GCNT2_uc003mze.2_Silent_p.L323L	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	323	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		CTGGAAACCTCAGAGCTATAA	0.507													0	0	0	0.010504	0	18	28										T	10621627	C	T	10621627	2	4	50	1	0	0	0	0	0	0	0	1	6301	813	29	1		1	GCNT2	6	10621627	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	7666750	10621627	160493440	42	14096										
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333766	28333766	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cctttaggcgaagttcacatCtcctgagacatcagaggatc	9	11	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:28333766C>T	uc003nle.3	+	6	1537	c.1321C>T	c.(1321-1323)CTC>TTC	p.L441F	ZKSCAN3_uc010jrc.2_Missense_Mutation_p.L441F|ZKSCAN3_uc003nlf.3_Missense_Mutation_p.L293F|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	441	C2H2-type 5.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AAGTTCACATCTCCTGAGACA	0.498													0	0	0	0.024334	0	26	35										T	28333766	C	T	28333766	3	4	50	1	0	0	0	0	1	0	0	0	17685	913	32	1	1339	1	ZKSCAN3	6	28333766	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	17712139	28333766	142781301	43	14097										
DOM3Z	1797	broad.mit.edu	37	chr6	31938495	31938495	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggggtctgtgcagtctacctCccctgagaagagcagagggt	15	10	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:31938495C>G	uc003nyo.1	-	3	1234	c.700G>C	c.(700-702)GAG>CAG	p.E234Q	DOM3Z_uc003nyp.1_Missense_Mutation_p.E234Q|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_Missense_Mutation_p.E234Q|DOM3Z_uc003nys.1_3'UTR|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	234		GDP (By similarity).					identical protein binding|metal ion binding|nucleotide binding				0						CAGTCTACCTCCCCTGAGAAG	0.617													0	0	0	0.01441	0	85	105										G	31938495	C	G	31938495	3	3	50	1	0	0	0	0	1	0	0	0	4705	864	30	1	506	1	DOM3Z	6	31938495	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	3604729	31938495	139176572	44	14098										
DOM3Z	1797	broad.mit.edu	37	chr6	31938905	31938905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ccgccacgtcactatggcctCtgccagccagcctggacccc	9	20	2	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:31938905C>G	uc003nyo.1	-	2	910	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	DOM3Z_uc003nyp.1_Missense_Mutation_p.E126Q|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_Missense_Mutation_p.E126Q|DOM3Z_uc003nys.1_Missense_Mutation_p.E126Q|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	126							identical protein binding|metal ion binding|nucleotide binding				0						ACTATGGCCTCTGCCAGCCAG	0.592													0	0	0	0.01441	0	44	74										G	31938905	C	G	31938905	3	3	50	1	0	0	0	0	1	0	0	0	4705	922	32	1	834	1	DOM3Z	6	31938905	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	410	31938905	139176162	45	14099										
HLA-DRB1	3123	broad.mit.edu	37	chr6	32551898	32551898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atgctcacctcgccgctgcaCtgtgaagctctccacaaccc	7	18	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:32551898C>T	uc003obp.3	-	2	401	c.358G>A	c.(358-360)GTG>ATG	p.V120M	HLA-DRB1_uc011dqa.1_Translation_Start_Site|HLA-DRB5_uc003obk.3_Intron|HLA-DRB6_uc003obo.1_RNA|HLA-DRB1_uc011dqb.1_5'Flank|HLA-DRB1_uc011dqc.1_Translation_Start_Site	NM_002124	NP_002115	P01911	2B1F_HUMAN	major histocompatibility complex, class II, DR	120	Beta-1.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				skin(1)	1						CGCCGCTGCACTGTGAAGCTC	0.527									Rheumatoid_Arthritis|Sj_gren_syndrome	Multiple Myeloma(14;0.17)			0	0	0	0.00308	0	7	15										T	32551898	C	T	32551898	3	4	50	1	0	0	0	0	1	0	0	0	7208	565	20	2	462	2	HLA-DRB1	6	32551898	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	612993	32551898	138563169	46	14100										
BAI3	577	broad.mit.edu	37	chr6	70098735	70098735	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcagagtgggagaagtgtctGaatttgcctctggatgtgca	15	6	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:70098735G>C	uc003pev.3	+	32	4969	c.4521G>C	c.(4519-4521)CTG>CTC	p.L1507L	BAI3_uc010kak.2_Silent_p.L1507L|BAI3_uc011dxx.1_Silent_p.L713L	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1507	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AGAAGTGTCTGAATTTGCCTC	0.418													0	0	0	0.009535	0	28	28										C	70098735	G	C	70098735	2	2	50	1	0	0	0	0	0	0	0	1	1300	1277	45	1		1	BAI3	6	70098735	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	37546837	70098735	101016332	47	14101										
ASF1A	25842	broad.mit.edu	37	chr6	119221997	119221997	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atacgatcaagttttagactCtgttttagtgggtcctgttc	9	7	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:119221997C>T	uc011ebn.1	+	2	513	c.176C>T	c.(175-177)TCT>TTT	p.S59F		NM_014034	NP_054753	Q9Y294	ASF1A_HUMAN	ASF1 anti-silencing function 1 homolog A	59	Interaction with histone H3, CHAF1B, and HIRA.				chromatin modification|DNA repair|loss of chromatin silencing|nucleosome assembly|transcription, DNA-dependent	chromatin remodeling complex	chromatin binding|histone binding				0		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0633)|OV - Ovarian serous cystadenocarcinoma(136;0.188)		GTTTTAGACTCTGTTTTAGTG	0.358													0	0	0	0.01441	0	82	110										T	119221997	C	T	119221997	3	4	50	1	0	0	0	0	1	0	0	0	1037	913	32	1	69	1	ASF1A	6	119221997	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	49123262	119221997	51893070	48	14102										
STX11	8676	broad.mit.edu	37	chr6	144508138	144508138	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cggcccgcactcggcagtggCgcgcatttcgcgggcgcagt	16	15	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr6:144508138C>T	uc003qks.3	+	2	566	c.374C>T	c.(373-375)GCG>GTG	p.A125V		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	125				HSAVAR -> ALGSGG (in Ref. 1; AAD02107).	cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TCGGCAGTGGCGCGCATTTCG	0.672									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.00632	0	28	39										T	144508138	C	T	144508138	3	4	50	1	0	0	0	0	1	0	0	0	15336	768	27	2	376	2	STX11	6	144508138	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	25286141	144508138	26606929	49	14103										
MICALL2	79778	broad.mit.edu	37	chr7	1474248	1474249	+	Frame_Shift_Ins	INS	-	-	T													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ctactactgggaggggctgcINSttttgctttttggtgaccag							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:1474248_1474249insT	uc003skj.3	-	17	2845_2846	c.2698_2699insA	c.(2698-2700)AGCfs	p.S900fs	MICALL2_uc003skh.3_Frame_Shift_Ins_p.K107fs|MICALL2_uc003ski.3_Frame_Shift_Ins_p.K385fs	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	900						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GGAGGGGCTGCTTTTGCTTTTT	0.639																		7	238	---	---								T	1474249	-	T	1474248	7	5	50	1	0	1	1	0	0	0	0	0	9574	797	28	0	19	0	MICALL2	7	1474248	Frame_Shift_Ins	INS	-	TCGA-DK-A1AG-01A-11D-A13W-08		1474248	157664415	50	14104										
FBXL18	80028	broad.mit.edu	37	chr7	5541202	5541202	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cgggggccaggcgcgcatagAagacccgcaggttctggtag	17	11	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:5541202A>G	uc003soo.2	-	3	792	c.698T>C	c.(697-699)TTC>TCC	p.F233S	FBXL18_uc003son.3_Missense_Mutation_p.F233S	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	233										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		GCGCGCATAGAAGACCCGCAG	0.642													0	0	0	0.013537	0	13	87										G	5541202	A	G	5541202	3	3	50	1	0	0	0	0	1	0	0	0	5714	246	9	5	1470	5	FBXL18	7	5541202	Missense_Mutation	SNP	A	TCGA-DK-A1AG-01A-11D-A13W-08	4066954	5541202	153597461	51	14105										
SP4	6671	broad.mit.edu	37	chr7	21550696	21550696	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggtttatgcggagtgatcatCtctccaaacatgtcaaaacg	9	9	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:21550696C>G	uc003sva.2	+	6	2345	c.2164C>G	c.(2164-2166)CTC>GTC	p.L722V	SP4_uc003svb.2_Missense_Mutation_p.L409V	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	722	C2H2-type 3.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GAGTGATCATCTCTCCAAACA	0.413													0	0	0	0.019004	0	38	41										G	21550696	C	G	21550696	3	3	50	1	0	0	0	0	1	0	0	0	14966	913	32	1	2186	1	SP4	7	21550696	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	16009494	21550696	137587967	52	14106										
OSBPL3	26031	broad.mit.edu	37	chr7	24911608	24911608	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagggccacttcctctttttCagcaaaaatcctttctgaac	5	12	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:24911608C>T	uc003sxf.2	-	3	582	c.177G>A	c.(175-177)CTG>CTA	p.L59L	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Silent_p.L59L|OSBPL3_uc003sxh.2_Silent_p.L59L|OSBPL3_uc003sxi.2_Silent_p.L59L	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	59	PH.				lipid transport		lipid binding|protein binding			skin(1)	1						TCCTCTTTTTCAGCAAAAATC	0.502													0	0	0	0.008361	0	28	61										T	24911608	C	T	24911608	2	4	50	1	0	0	0	0	0	0	0	1	11279	813	29	1		1	OSBPL3	7	24911608	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	3360912	24911608	134227055	53	14107										
POLM	27434	broad.mit.edu	37	chr7	44113402	44113402	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cttggagccagtccaaccgaGcagggcgaaagggaactggc	15	11	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:44113402G>A	uc003tjt.2	-	9	1386	c.1294C>T	c.(1294-1296)CTC>TTC	p.L432F	POLM_uc003tjw.1_Missense_Mutation_p.L51F|POLM_uc003tju.2_Missense_Mutation_p.L395F|POLM_uc003tjx.2_Missense_Mutation_p.L352F|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Missense_Mutation_p.L82F	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	432					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						GTCCAACCGAGCAGGGCGAAA	0.657								DNA_polymerases_(catalytic_subunits)					0	0	0	0.012213	0	31	140										A	44113402	G	A	44113402	3	1	50	1	0	0	0	0	1	0	0	0	12206	971	34	2	202	2	POLM	7	44113402	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	19201794	44113402	115025261	54	14108										
ASL	435	broad.mit.edu	37	chr7	65553885	65553885	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgcaccaaggaattcagcttCgtgcagctctcagatgccta	9	12	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:65553885C>T	uc003tuo.2	+	11	921	c.810C>T	c.(808-810)TTC>TTT	p.F270F	ASL_uc003tup.2_Silent_p.F270F|ASL_uc003tur.2_Silent_p.F244F|ASL_uc003tuq.2_Silent_p.F270F	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	270					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	AATTCAGCTTCGTGCAGCTCT	0.617													0	0	0	0.017118	0	38	41										T	65553885	C	T	65553885	2	4	50	1	0	0	0	0	0	0	0	1	1044	883	31	1		1	ASL	7	65553885	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	21440483	65553885	93584778	55	14109										
AGFG2	3268	broad.mit.edu	37	chr7	100151029	100151029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caaaggcagtgcctccacccCtgtgcagggctccatcccag	10	17	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr7:100151029C>T	uc003uvf.2	+	4	627	c.491C>T	c.(490-492)CCT>CTT	p.P164L	AGFG2_uc003uvg.1_Intron|AGFG2_uc010lgy.2_Silent_p.L26L	NM_006076	NP_006067	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	164					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			central_nervous_system(1)	1						GCCTCCACCCCTGTGCAGGGC	0.547													0	0	0	0.01441	0	66	96										T	100151029	C	T	100151029	3	4	50	1	0	0	0	0	1	0	0	0	381	681	24	2	505	2	AGFG2	7	100151029	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	34597144	100151029	58987634	56	14110										
ELP3	55140	broad.mit.edu	37	chr8	27995406	27995406	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	actcgagtgtaccgagtacaGaggtagtgtgttatctttta	11	6	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:27995406G>C	uc003xgo.3	+	10	1246	c.1098G>C	c.(1096-1098)CAG>CAC	p.Q366H	ELP3_uc003xgn.3_Missense_Mutation_p.Q351H|ELP3_uc011laq.1_Missense_Mutation_p.Q294H|ELP3_uc011lar.1_Missense_Mutation_p.Q274H|ELP3_uc011las.1_Missense_Mutation_p.Q247H|ELP3_uc011lat.1_Missense_Mutation_p.Q247H	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	elongation protein 3 homolog	366					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding				0		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		ACCGAGTACAGAGGTAGTGTG	0.408													0	0	0	0.008291	0	11	13										C	27995406	G	C	27995406	3	2	50	1	0	0	0	0	1	0	0	0	5081	933	33	1	1136	1	ELP3	8	27995406	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		27995406	118368616	57	14111										
CYP7A1	1581	broad.mit.edu	37	chr8	59404977	59404977	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtaaagagctatgatgtcatCttttcggatgttgtaggaac	11	5	2	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:59404977C>G	uc003xtm.3	-	5	1213	c.1150G>C	c.(1150-1152)GAT>CAT	p.D384H		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	384					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ATGATGTCATCTTTTCGGATG	0.468									Neonatal_Giant_Cell_Hepatitis				0	0	0	0.01441	0	52	73										G	59404977	C	G	59404977	3	3	50	1	0	0	0	0	1	0	0	0	4196	913	32	1	372	1	CYP7A1	8	59404977	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	31409571	59404977	86959045	58	14112										
CNBD1	168975	broad.mit.edu	37	chr8	87878760	87878760	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ttccagcagctattttgtctCacatgacagctattaacaat	5	10	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:87878760C>G	uc003ydy.2	+	1	85	c.37C>G	c.(37-39)CAC>GAC	p.H13D		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	13										ovary(3)	3						TATTTTGTCTCACATGACAGC	0.443													0	0	0	0.016723	0	12	13										G	87878760	C	G	87878760	3	3	50	1	0	0	0	0	1	0	0	0	3591	826	29	1	39	1	CNBD1	8	87878760	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	28473783	87878760	58485262	59	14113										
TP53INP1	94241	broad.mit.edu	37	chr8	95953097	95953097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ccattcatcatcttctttctCattgaattctggttcttggt	5	10	7	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:95953097C>G	uc003yhg.2	-	2	457	c.73G>C	c.(73-75)GAG>CAG	p.E25Q	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_Missense_Mutation_p.E25Q	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	25	Glu-rich.				apoptosis	PML body					0	Breast(36;8.75e-07)					TCTTCTTTCTCATTGAATTCT	0.398													0	0	0	0.023175	0	37	57										G	95953097	C	G	95953097	3	3	50	1	0	0	0	0	1	0	0	0	16385	835	29	1	687	1	TP53INP1	8	95953097	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	8074337	95953097	50410925	60	14114										
TG	7038	broad.mit.edu	37	chr8	134042190	134042190	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tccctggcagcagaccgtggCggggctgatgtggccagcat	16	12	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:134042190C>T	uc003ytw.2	+	41	7202	c.7161C>T	c.(7159-7161)GGC>GGT	p.G2387G	TG_uc010mdw.2_Silent_p.G1146G|TG_uc011ljb.1_Silent_p.G756G|TG_uc011ljc.1_Silent_p.G520G	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2387					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGACCGTGGCGGGGCTGATG	0.647													0	0	0	0.006214	0	6	50										T	134042190	C	T	134042190	2	4	50	1	0	0	0	0	0	0	0	1	15810	755	27	2		2	TG	8	134042190	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	38089093	134042190	12321832	61	14115										
MAPK15	225689	broad.mit.edu	37	chr8	144803972	144803972	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tccctgacctcccaggctgcGgctcaggtggccaaccaggc	12	17	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:144803972G>A	uc003yzj.2	+	13	1421	c.1380G>A	c.(1378-1380)GCG>GCA	p.A460A		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	460					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCCAGGCTGCGGCTCAGGTGG	0.672													0	0	0	0.016723	0	14	130										A	144803972	G	A	144803972	2	1	50	1	0	0	0	0	0	0	0	1	9277	1103	39	2		2	MAPK15	8	144803972	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	10761782	144803972	1560050	62	14116										
ZNF16	7564	broad.mit.edu	37	chr8	146171568	146171568	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gagctccatctctgcctcctCacggcgagttctgaggctgg	12	14	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr8:146171568C>T	uc003zet.2	-	3	212	c.25G>A	c.(25-27)GAG>AAG	p.E9K	ZNF16_uc003zeu.2_Missense_Mutation_p.E9K	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TCTGCCTCCTCACGGCGAGTT	0.592													0	0	0	0.01441	0	52	57										T	146171568	C	T	146171568	3	4	50	1	0	0	0	0	1	0	0	0	17735	835	29	1	2031	1	ZNF16	8	146171568	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1367596	146171568	192454	63	14117										
PSIP1	11168	broad.mit.edu	37	chr9	15479597	15479609	+	Frame_Shift_Del	DEL	CGTCCTCTTTTAG	CGTCCTCTTTTAG	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cagtaatcctacctgcaggtCgtcctcttttaggactcact							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr9:15479597_15479609delCGTCCTCTTTTAG	uc003zlv.3	-	7	863_875	c.533_545delCTAAAAGAGGACG	c.(532-546)CCTAAAAGAGGACGAfs	p.P178fs	PSIP1_uc003zlw.3_Frame_Shift_Del_p.P178fs|PSIP1_uc003zlz.3_Frame_Shift_Del_p.P178fs|PSIP1_uc003zma.3_Frame_Shift_Del_p.P169fs|PSIP1_uc003zly.2_Frame_Shift_Del_p.P178fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	178_182					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		ACCTGCAGGTCGTCCTCTTTTAGGACTCACTTT	0.362																		10	17	---	---								-	15479609	CGTCCTCTTTTAG	-	15479597	7	5	50	1	0	1	0	1	0	0	0	0	12663	884	31	0	1116	0	PSIP1	9	15479597	Frame_Shift_Del	DEL	CGTCCTCTTTTAG	TCGA-DK-A1AG-01A-11D-A13W-08		15479597	125733834	64	14118										
CNTLN	54875	broad.mit.edu	37	chr9	17466028	17466028	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caagaaggtatcaattgattCactaaagcaaagacttaacg	7	7	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr9:17466028C>T	uc003zmz.2	+	22	3604	c.3578C>T	c.(3577-3579)TCA>TTA	p.S1193L	CNTLN_uc003zmy.2_Missense_Mutation_p.S1194L|CNTLN_uc010mio.2_Missense_Mutation_p.S873L	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1194	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		TCAATTGATTCACTAAAGCAA	0.299													0	0	0	0.027356	0	27	6										T	17466028	C	T	17466028	3	4	50	1	0	0	0	0	1	0	0	0	3639	838	29	1	3697	1	CNTLN	9	17466028	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1986431	17466028	123747403	65	14119										
ZNF658	26149	broad.mit.edu	37	chr9	40773179	40773179	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tctgatgtattttgagggctGaattatgggcaaaagttttc	11	4	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr9:40773179G>C	uc004abs.2	-	5	2248	c.2096C>G	c.(2095-2097)TCA>TGA	p.S699*	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Nonsense_Mutation_p.S699*	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	699	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTTGAGGGCTGAATTATGGGC	0.408													0	0	0	0.007835	0	35	145										C	40773179	G	C	40773179	4	2	50	1	0	0	0	0	0	1	0	0	18066	1294	45	1	1087	1	ZNF658	9	40773179	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	23307151	40773179	100440252	66	14120										
GOLGA2	2801	broad.mit.edu	37	chr9	131019750	131019750	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caggaatctgccatgccactCgttgcggtcgcccacaagcc	10	16	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr9:131019750C>T	uc011maw.1	-	25	2705	c.2692G>A	c.(2692-2694)GAG>AAG	p.E898K	GOLGA2_uc010mxw.2_Missense_Mutation_p.E221K|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	898						Golgi cisterna membrane	protein binding			ovary(1)	1						CCATGCCACTCGTTGCGGTCG	0.662													0	0	0	0.01441	0	47	7										T	131019750	C	T	131019750	3	4	50	1	0	0	0	0	1	0	0	0	6552	893	31	1	324	1	GOLGA2	9	131019750	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	90246571	131019750	10193681	67	14121										
GATA3	2625	broad.mit.edu	37	chr10	8115929	8115929	+	Frame_Shift_Del	DEL	A	A	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cccacgccgatgcacccgccAtccagcctgtcctttggacc							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr10:8115929delA	uc001ika.2	+	6	1832	c.1275delA	c.(1273-1275)CCAfs	p.P425fs	GATA3_uc001ijz.2_Frame_Shift_Del_p.P426fs	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	425				P -> A (in Ref. 4; AAA35870).	aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						TGCACCCGCCATCCAGCCTGT	0.662			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)											47	106	---	---								-	8115929	A	-	8115929	7	5	50	1	0	1	0	1	0	0	0	0	6255	204	8	0	1296	0	GATA3	10	8115929	Frame_Shift_Del	DEL	A	TCGA-DK-A1AG-01A-11D-A13W-08		8115929	127418818	68	14122										
KIAA1217	56243	broad.mit.edu	37	chr10	24810779	24810779	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagtggaggccgtgcggtttCtgaaggaggagccacacaag	16	8	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr10:24810779C>T	uc001iru.3	+	12	2780	c.2377C>T	c.(2377-2379)CTG>TTG	p.L793L	KIAA1217_uc001irs.2_Silent_p.L713L|KIAA1217_uc001irt.3_Silent_p.L758L|KIAA1217_uc010qcy.1_Silent_p.L758L|KIAA1217_uc010qcz.1_Silent_p.L758L|KIAA1217_uc001irv.1_Silent_p.L608L|KIAA1217_uc010qda.1_Intron|KIAA1217_uc001irw.2_Silent_p.L476L|KIAA1217_uc001irz.2_Silent_p.L476L|KIAA1217_uc001irx.2_Silent_p.L476L|KIAA1217_uc001iry.2_Silent_p.L476L	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	793					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CGTGCGGTTTCTGAAGGAGGA	0.577													0	0	0	0.013114	0	39	62										T	24810779	C	T	24810779	2	4	50	1	0	0	0	0	0	0	0	1	8216	912	32	1		1	KIAA1217	10	24810779	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	16694850	24810779	110723968	69	14123										
PTCHD3	374308	broad.mit.edu	37	chr10	27702774	27702774	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caggaagatccaggggtgcgCgcccacctgccaccccagcc	12	18	0	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr10:27702774C>T	uc001itu.2	-	1	524	c.406G>A	c.(406-408)GCG>ACG	p.A136T		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	136					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CAGGGGTGCGCGCCCACCTGC	0.667													0	0	0	0.01441	0	56	56										T	27702774	C	T	27702774	3	4	50	1	0	0	0	0	1	0	0	0	12734	768	27	2	1913	2	PTCHD3	10	27702774	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	2891995	27702774	107831973	70	14124										
PDZD8	118987	broad.mit.edu	37	chr10	119043793	119043793	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	agaacagaaacttcttcaacCaaatggggttctttttcttt	6	8	4	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr10:119043793C>A	uc001lde.1	-	5	2650	c.2451G>T	c.(2449-2451)TTG>TTT	p.L817F		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	817					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CTTCTTCAACCAAATGGGGTT	0.368													1	0	0.00909568	0.009096	0.00919618	4	63										A	119043793	C	A	119043793	3	1	50	1	0	0	0	0	1	0	0	0	11705	593	21	4	1017	4	PDZD8	10	119043793	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	91341019	119043793	16490954	71	14125										
DMBT1	1755	broad.mit.edu	37	chr10	124339372	124339372	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcccccacaatggctggctcAcccacaactgtggccatagt	9	16	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr10:124339372A>T	uc001lgk.1	+	10	1064	c.958A>T	c.(958-960)ACC>TCC	p.T320S	DMBT1_uc001lgl.1_Missense_Mutation_p.T320S|DMBT1_uc001lgm.1_Missense_Mutation_p.T320S|DMBT1_uc009xzz.1_Missense_Mutation_p.T320S|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.T172S	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	320	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGCTGGCTCACCCACAACTG	0.572													0	0	0	0.027894	0	34	89										T	124339372	A	T	124339372	3	4	50	1	0	0	0	0	1	0	0	0	4577	159	6	5	996	5	DMBT1	10	124339372	Missense_Mutation	SNP	A	TCGA-DK-A1AG-01A-11D-A13W-08	5295579	124339372	11195375	72	14126										
CHRNA10	57053	broad.mit.edu	37	chr11	3688596	3688596	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcaggtggaaggcgagcggcGcaagcagcgagatgagcacg	19	9	0	2	rs140976405		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:3688596G>A	uc001lyf.2	-	4	833	c.761C>T	c.(760-762)GCG>GTG	p.A254V	CHRNA10_uc010qxt.1_Missense_Mutation_p.A48V|CHRNA10_uc010qxu.1_Missense_Mutation_p.A48V	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	254	Helical; (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	GGCGAGCGGCGCAAGCAGCGA	0.697													0	0	0	0.010818	0	30	30										A	3688596	G	A	3688596	3	1	50	1	0	0	0	0	1	0	0	0	3382	1087	38	2	599	2	CHRNA10	11	3688596	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		3688596	131317920	73	14127										
MICAL2	9645	broad.mit.edu	37	chr11	12234924	12234924	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtgtggctttcatcttcaatCagaaattttttcaggacctt	7	8	5	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:12234924C>G	uc001mjz.2	+	7	1102	c.814C>G	c.(814-816)CAG>GAG	p.Q272E	MICAL2_uc010rch.1_Missense_Mutation_p.Q272E|MICAL2_uc001mka.2_Missense_Mutation_p.Q272E|MICAL2_uc010rci.1_Missense_Mutation_p.Q272E|MICAL2_uc001mkb.2_Missense_Mutation_p.Q272E|MICAL2_uc001mkc.2_Missense_Mutation_p.Q272E|MICAL2_uc001mkd.2_Missense_Mutation_p.Q101E|MICAL2_uc001mke.2_5'Flank	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	272						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CATCTTCAATCAGAAATTTTT	0.463													0	0	0	0.01441	0	76	125										G	12234924	C	G	12234924	3	3	50	1	0	0	0	0	1	0	0	0	9570	827	29	1	832	1	MICAL2	11	12234924	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	8546328	12234924	122771592	74	14128										
INTS5	80789	broad.mit.edu	37	chr11	62415960	62415961	+	Missense_Mutation	DNP	TC	TC	AT													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	actgggtggccaaactcaacTcttcagggcttcgggctcgg							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:62415960_62415961TC>AT	uc001nud.2	-	2	1644_1645	c.1591_1592GA>AT	c.(1591-1593)GAG>ATG	p.E531M	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	531					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CAAACTCAACTCTTCAGGGCTT	0.624													0	0	0	0.004672	0	112	140										AT	62415961	TC	AT	62415960	3	1	50	1	0	0	0	0	1	0	0	0	7781	1551	54	5	1471	5	INTS5	11	62415960	Missense_Mutation	DNP	TC	TCGA-DK-A1AG-01A-11D-A13W-08	50181036	62415960	72590556	75	14129										
SSH3	54961	broad.mit.edu	37	chr11	67077296	67077312	+	Frame_Shift_Del	DEL	CACAGTGCTGGCCTATG	CACAGTGCTGGCCTATG	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggcgtcagccgctcagcggcCacagtgctggcctatgccat							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:67077296_67077312delCACAGTGCTGGCCTATG	uc001okj.2	+	12	1444_1460	c.1266_1282delCACAGTGCTGGCCTATG	c.(1264-1284)GCCACAGTGCTGGCCTATGCCfs	p.A422fs	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Frame_Shift_Del_p.A276fs	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	422_428	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCTCAGCGGCCACAGTGCTGGCCTATGCCATGAAGCA	0.664																		58	247	---	---								-	67077312	CACAGTGCTGGCCTATG	-	67077296	7	5	50	1	0	1	0	1	0	0	0	0	15185	581	21	0	1312	0	SSH3	11	67077296	Frame_Shift_Del	DEL	CACAGTGCTGGCCTATG	TCGA-DK-A1AG-01A-11D-A13W-08	4661336	67077296	67929220	76	14130										
AMOTL1	154810	broad.mit.edu	37	chr11	94599320	94599320	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagaaggaagagaagacctgGaaggggagcataggtgagcc	17	5	0	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:94599320G>A	uc001pfb.2	+	11	2645	c.2475G>A	c.(2473-2475)TGG>TGA	p.W825*	AMOTL1_uc001pfc.2_Nonsense_Mutation_p.W775*	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	825						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				AGAAGACCTGGAAGGGGAGCA	0.458													0	0	0	0.008871	0	20	25										A	94599320	G	A	94599320	4	1	50	1	0	0	0	0	0	1	0	0	583	1183	41	1	2517	1	AMOTL1	11	94599320	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	27522024	94599320	40407196	77	14131										
MMP3	4314	broad.mit.edu	37	chr11	102709926	102709926	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gatggccaaaatgaagagatCaaatgcaattcaggttcaag	10	6	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:102709926C>T	uc001phj.1	-	7	1049	c.984G>A	c.(982-984)TTG>TTA	p.L328L		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	328	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	ATGAAGAGATCAAATGCAATT	0.358													0	0	0	0.01441	0	50	70										T	102709926	C	T	102709926	2	4	50	1	0	0	0	0	0	0	0	1	9666	825	29	1		1	MMP3	11	102709926	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	8110606	102709926	32296590	78	14132										
ATM	472	broad.mit.edu	37	chr11	108117799	108117799	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aaagtattcttcaggatttcGtaatattgccgtcaaagaaa	7	6	3	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:108117799G>A	uc001pkb.1	+	8	1395	c.1010G>A	c.(1009-1011)CGT>CAT	p.R337H	ATM_uc009yxr.1_Missense_Mutation_p.R337H	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	337			R -> C (in a colorectal adenocarcinoma sample; somatic mutation).|R -> H (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R337C(2)|p.R337S(2)|p.R337H(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TCAGGATTTCGTAATATTGCC	0.323			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.024334	0	25	32										A	108117799	G	A	108117799	3	1	50	1	0	0	0	0	1	0	0	0	1109	1145	40	2	1036	2	ATM	11	108117799	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	5407873	108117799	26888717	79	14133										
VPS26B	112936	broad.mit.edu	37	chr11	134114848	134114848	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	acaggagagtccatcccgatCcggctcttcctggccgggta	12	14	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr11:134114848C>G	uc001qhe.2	+	5	1194	c.738C>G	c.(736-738)ATC>ATG	p.I246M		NM_052875	NP_443107	Q4G0F5	VP26B_HUMAN	vacuolar protein sorting 26 homolog B	246					protein transport|vacuolar transport	cytosol|retromer complex					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;2.43e-10)|all cancers(11;2.94e-09)|BRCA - Breast invasive adenocarcinoma(10;9.57e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00164)|Lung(977;0.216)		CCATCCCGATCCGGCTCTTCC	0.582											OREG0021548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009718	0	37	67										G	134114848	C	G	134114848	3	3	50	1	0	0	0	0	1	0	0	0	17195	845	30	1	756	1	VPS26B	11	134114848	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	25997049	134114848	891668	80	14134										
LRTM2	654429	broad.mit.edu	37	chr12	1940449	1940449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cagggacctgctgcggcactCgccgctgctccgccacctgg	13	18	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr12:1940449C>T	uc001qjt.2	+	4	1222	c.416C>T	c.(415-417)TCG>TTG	p.S139L	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Missense_Mutation_p.S139L|LRTM2_uc010sdx.1_Missense_Mutation_p.S139L|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	139	Extracellular (Potential).|LRR 3.					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CTGCGGCACTCGCCGCTGCTC	0.652													0	0	0	0.01441	0	96	100										T	1940449	C	T	1940449	3	4	50	1	0	0	0	0	1	0	0	0	9045	893	31	1	422	1	LRTM2	12	1940449	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		1940449	131911446	81	14135										
DNM1L	10059	broad.mit.edu	37	chr12	32873665	32873665	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtgatgagtatgcttttcttCaaaagaaatatccatctctg	7	7	3	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr12:32873665C>T	uc001rld.2	+	8	969	c.808C>T	c.(808-810)CAA>TAA	p.Q270*	DNM1L_uc010skf.1_RNA|DNM1L_uc010skg.1_RNA|DNM1L_uc001rle.2_Nonsense_Mutation_p.Q270*|DNM1L_uc001rlf.2_Nonsense_Mutation_p.Q270*|DNM1L_uc010skh.1_Nonsense_Mutation_p.Q336*|DNM1L_uc001rlg.2_Nonsense_Mutation_p.Q336*|DNM1L_uc001rlh.2_Nonsense_Mutation_p.Q323*|DNM1L_uc010ski.1_Nonsense_Mutation_p.Q67*	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	270	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGCTTTTCTTCAAAAGAAATA	0.348													0	0	0	0.009535	0	31	53										T	32873665	C	T	32873665	4	4	50	1	0	0	0	0	0	1	0	0	4671	827	29	1	838	1	DNM1L	12	32873665	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	30933216	32873665	100978230	82	14136										
ERBB3	2065	broad.mit.edu	37	chr12	56478817	56478817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggctatgtcctcgtggccatGaatgaattctctactctacc	8	12	2	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr12:56478817G>A	uc001sjh.2	+	3	466	c.273G>A	c.(271-273)ATG>ATA	p.M91I	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.M32I|ERBB3_uc001sjg.2_Missense_Mutation_p.M91I	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	91	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TCGTGGCCATGAATGAATTCT	0.473													0	0	0	0.01441	0	57	107										A	56478817	G	A	56478817	3	1	50	1	0	0	0	0	1	0	0	0	5208	1290	45	1	283	1	ERBB3	12	56478817	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	23605152	56478817	77373078	83	14137										
OAS3	4940	broad.mit.edu	37	chr12	113385903	113385903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	agtgcagtcttggaaggggcCggtaagtgagggggccccag	19	8	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr12:113385903C>T	uc001tug.2	+	5	1115	c.1028C>T	c.(1027-1029)CCG>CTG	p.P343L		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	343	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						TGGAAGGGGCCGGTAAGTGAG	0.567													0	0	0	0.010504	0	18	32										T	113385903	C	T	113385903	3	4	50	1	0	0	0	0	1	0	0	0	10801	666	23	2	1046	2	OAS3	12	113385903	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	56907086	113385903	20465992	84	14138										
ATP12A	479	broad.mit.edu	37	chr13	25283562	25283562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	acatcatgaacaggaagcctCgccacaagaataaggacagg	10	10	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:25283562C>T	uc001upp.2	+	18	2741	c.2554C>T	c.(2554-2556)CGC>TGC	p.R852C	ATP12A_uc010aaa.2_Missense_Mutation_p.R858C	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	852	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CAGGAAGCCTCGCCACAAGAA	0.557													0	0	0	0.015359	0	34	37										T	25283562	C	T	25283562	3	4	50	1	0	0	0	0	1	0	0	0	1122	884	31	1	2642	1	ATP12A	13	25283562	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		25283562	89886316	85	14139										
BRCA2	675	broad.mit.edu	37	chr13	32910686	32910686	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagtttcagatataaaagaaGaggtcttggctgcagcatgt	11	5	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:32910686G>C	uc001uub.1	+	11	2421	c.2194G>C	c.(2194-2196)GAG>CAG	p.E732Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	732	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TATAAAAGAAGAGGTCTTGGC	0.373			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.027356	0	26	29										C	32910686	G	C	32910686	3	2	50	1	0	0	0	0	1	0	0	0	1499	943	33	1	2232	1	BRCA2	13	32910686	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	7627124	32910686	82259192	86	14140										
TRPC4	7223	broad.mit.edu	37	chr13	38211379	38211379	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gcaacttcttctgaaacagaGaagatttggtttgcattttg	9	6	2	3	rs146885289		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:38211379G>T	uc001uws.2	-	11	2830	c.2595C>A	c.(2593-2595)TTC>TTA	p.F865L	TRPC4_uc010abv.2_Missense_Mutation_p.F445L|TRPC4_uc001uwt.2_Intron|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Missense_Mutation_p.F692L|TRPC4_uc010abx.2_Missense_Mutation_p.F870L|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	865	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity	p.F865F(1)		ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CTGAAACAGAGAAGATTTGGT	0.413													1	0	5.18039e-06	0.00308	5.29615e-06	7	79										T	38211379	G	T	38211379	3	4	50	1	0	0	0	0	1	0	0	0	16577	933	33	3	342	3	TRPC4	13	38211379	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	5300693	38211379	76958499	87	14141										
THSD1	55901	broad.mit.edu	37	chr13	52952331	52952331	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	actgaccgcgggctgctccgGaaatggggatttgatccgga	15	10	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:52952331G>A	uc001vgo.2	-	5	2319	c.1774C>T	c.(1774-1776)CCG>TCG	p.P592S	THSD1_uc001vgp.2_Missense_Mutation_p.P539S|THSD1_uc010tgz.1_Missense_Mutation_p.P213S|THSD1_uc010aea.2_Missense_Mutation_p.P53S	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	592	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GGCTGCTCCGGAAATGGGGAT	0.582													0	0	0	0.01441	0	68	83										A	52952331	G	A	52952331	3	1	50	1	0	0	0	0	1	0	0	0	15874	1174	41	1	788	1	THSD1	13	52952331	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	14740952	52952331	62217547	88	14142			1	54		3	3	565	G		3.525206e-06
THSD1	55901	broad.mit.edu	37	chr13	52952573	52952573	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	actggaagctctcgctgccaGaggcatcatcctcgggaggt	13	12	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:52952573G>C	uc001vgo.2	-	5	2077	c.1532C>G	c.(1531-1533)TCT>TGT	p.S511C	THSD1_uc001vgp.2_Missense_Mutation_p.S458C|THSD1_uc010tgz.1_Missense_Mutation_p.S132C|THSD1_uc010aea.2_5'UTR	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	511	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CTCGCTGCCAGAGGCATCATC	0.602													0	0	0	0.01441	0	66	100										C	52952573	G	C	52952573	3	2	50	1	0	0	0	0	1	0	0	0	15874	942	33	1	1030	1	THSD1	13	52952573	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	242	52952573	62217305	89	14143			1	54		3	3	565	G		3.525206e-06
THSD1	55901	broad.mit.edu	37	chr13	52952895	52952895	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cttcactggaccctggggctGaagaggagatgggctggatg	17	8	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:52952895G>A	uc001vgo.2	-	5	1755	c.1210C>T	c.(1210-1212)CAG>TAG	p.Q404*	THSD1_uc001vgp.2_Nonsense_Mutation_p.Q351*|THSD1_uc010tgz.1_Nonsense_Mutation_p.Q25*|THSD1_uc010aea.2_5'UTR	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	404	Extracellular (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CCCTGGGGCTGAAGAGGAGAT	0.393													0	0	0	0.027356	0	26	46										A	52952895	G	A	52952895	4	1	50	1	0	0	0	0	0	1	0	0	15874	1299	45	1	1352	1	THSD1	13	52952895	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	322	52952895	62216983	90	14144			1	54		3	3	565	G		3.525206e-06
DACH1	1602	broad.mit.edu	37	chr13	72147065	72147065	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ctgaggtggttcatctggctCattgccatggtgacagatgc	13	9	3	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr13:72147065C>T	uc010thn.1	-	5	1629	c.1206G>A	c.(1204-1206)ATG>ATA	p.M402I	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	454					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCATCTGGCTCATTGCCATGG	0.453													0	0	0	0.010818	0	33	47										T	72147065	C	T	72147065	3	4	50	1	0	0	0	0	1	0	0	0	4220	826	29	1	946	1	DACH1	13	72147065	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	19194170	72147065	43022813	91	14145										
CHD8	57680	broad.mit.edu	37	chr14	21894345	21894345	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caggcatgacttccacatctGaattatcagatgaggtatta	8	8	2	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr14:21894345G>C	uc001was.1	-	5	915	c.821C>G	c.(820-822)TCA>TGA	p.S274*	CHD8_uc001war.1_Nonsense_Mutation_p.S170*	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	553					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTCCACATCTGAATTATCAGA	0.373													0	0	0	0.024245	0	15	16										C	21894345	G	C	21894345	4	2	50	1	0	0	0	0	0	1	0	0	3331	1294	45	1	6223	1	CHD8	14	21894345	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		21894345	85455195	92	14146										
DHRS4L1	728635	broad.mit.edu	37	chr14	24506961	24506961	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tctgctcacaggatcggcttCgccgtcgcccagcgtctggc	12	16	3	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr14:24506961C>G	uc010alc.2	+	2	138	c.138C>G	c.(136-138)TTC>TTG	p.F46L	DHRS4L1_uc010tnu.1_Intron	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4	46	NADP (By similarity).						binding|oxidoreductase activity				0						GGATCGGCTTCGCCGTCGCCC	0.458													0	0	0	0.008291	0	9	64										G	24506961	C	G	24506961	3	3	50	1	0	0	0	0	1	0	0	0	4493	883	31	1	144	1	DHRS4L1	14	24506961	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	2612616	24506961	82842579	93	14147										
C14orf182	283551	broad.mit.edu	37	chr14	50472404	50472404	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgtgatcttgaaagacctctCggttcgtgaatggcatcttg	11	8	3	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr14:50472404C>T	uc001wxi.1	-	1	1835	c.114G>A	c.(112-114)CCG>CCA	p.P38P		NM_001012706	NP_001012724	A1A4T8	CN182_HUMAN	hypothetical protein LOC283551	38											0						AAAGACCTCTCGGTTCGTGAA	0.537													0	0	0	0.01441	0	140	180										T	50472404	C	T	50472404	2	4	50	1	0	0	0	0	0	0	0	1	1765	871	31	1		1	C14orf182	14	50472404	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	25965443	50472404	56877136	94	14148										
DUOX2	50506	broad.mit.edu	37	chr15	45399061	45399061	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cagcagagagcaatgatggtGatggcaaaaccagggctgct	14	8	0	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr15:45399061G>A	uc010bea.2	-	15	2003	c.1800C>T	c.(1798-1800)ATC>ATT	p.I600I	DUOX2_uc001zun.2_Silent_p.I600I	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	600	Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CAATGATGGTGATGGCAAAAC	0.597													0	0	0	0.001984	0	7	11										A	45399061	G	A	45399061	2	1	50	1	0	0	0	0	0	0	0	1	4801	1280	45	1		1	DUOX2	15	45399061	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		45399061	57132331	95	14149										
RPP25	54913	broad.mit.edu	37	chr15	75248616	75248616	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gggaggctctgccacacctcGcgtacgctccggtagcgcag	14	15	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr15:75248616G>C	uc002azj.1	-	1	1160	c.309C>G	c.(307-309)CGC>CGG	p.R103R		NM_017793	NP_060263	Q9BUL9	RPP25_HUMAN	ribonuclease P 25kDa subunit	103					tRNA processing	nucleus	protein binding|ribonuclease P activity|RNA binding				0						GCCACACCTCGCGTACGCTCC	0.716													0	0	0	0.00308	0	7	18										C	75248616	G	C	75248616	2	2	50	1	0	0	0	0	0	0	0	1	13611	1074	38	4		4	RPP25	15	75248616	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	29849555	75248616	27282776	96	14150										
RHOT2	89941	broad.mit.edu	37	chr16	723543	723543	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cgggggctgctgggggttgtCggggccgccgtggccgcagt	22	11	0	0	rs140204401		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:723543C>T	uc002cip.2	+	19	1861	c.1794C>T	c.(1792-1794)GTC>GTT	p.V598V	RHOT2_uc002ciq.2_Silent_p.V491V|RHOT2_uc010bqy.2_Silent_p.V377V|RHBDL1_uc002cir.1_5'Flank|RHBDL1_uc010uun.1_5'Flank|RHBDL1_uc002cis.1_5'Flank	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	598	Miro 2.|Helical; Anchor for type IV membrane protein; (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				TGGGGGTTGTCGGGGCCGCCG	0.627													0	0	0	0.01441	0	127	144										T	723543	C	T	723543	2	4	50	1	0	0	0	0	0	0	0	1	13344	871	31	1		1	RHOT2	16	723543	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		723543	89631210	97	14151										
MRPS34	65993	broad.mit.edu	37	chr16	1822511	1822511	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cccgcgcctcgctctcagtcTtccctgatgaagaaaaagag	9	14	2	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:1822511T>C	uc002cmo.2	-	3	388	c.368A>G	c.(367-369)AAG>AGG	p.K123R	NME3_uc002cmm.2_5'Flank|NME3_uc010brv.2_5'Flank|MRPS34_uc002cmn.2_5'UTR|MRPS34_uc002cmp.1_Missense_Mutation_p.K130R|EME2_uc002cmq.1_5'Flank|EME2_uc010brw.1_5'Flank	NM_023936	NP_076425	P82930	RT34_HUMAN	mitochondrial ribosomal protein S34	123						mitochondrion|ribosome	protein binding			skin(2)	2						GCTCTCAGTCTTCCCTGATGA	0.627													0	0	0	0.020292	0	12	321										C	1822511	T	C	1822511	3	2	50	1	0	0	0	0	1	0	0	0	9843	1609	56	5	292	5	MRPS34	16	1822511	Missense_Mutation	SNP	T	TCGA-DK-A1AG-01A-11D-A13W-08	1098968	1822511	88532242	98	14152										
RPS2	6187	broad.mit.edu	37	chr16	2012571	2012571	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ataccagccatcatgagcagCttcttaggcacaggtgcgga	11	11	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:2012571C>T	uc002cnn.2	-	5	824	c.636G>A	c.(634-636)AAG>AAA	p.K212K	RPS2_uc010bsa.1_RNA|RPS2_uc002cnl.2_Silent_p.K154K|RPS2_uc002cnm.2_RNA|RPS2_uc002cno.2_Silent_p.K212K|SNORA10_uc002cnp.1_5'Flank|SNHG9_uc002cnr.2_5'Flank|SNORA78_uc002cns.1_5'Flank	NM_002952	NP_002943	P15880	RS2_HUMAN	ribosomal protein S2	212					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	fibroblast growth factor 1 binding|fibroblast growth factor 3 binding|RNA binding|structural constituent of ribosome				0						TCATGAGCAGCTTCTTAGGCA	0.632													0	0	0	0.01441	0	44	53										T	2012571	C	T	2012571	2	4	50	1	0	0	0	0	0	0	0	1	13631	796	28	2		2	RPS2	16	2012571	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	190060	2012571	88342182	99	14153										
PAQR4	124222	broad.mit.edu	37	chr16	3021898	3021898	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atcctgcagctgcacgccggCgtcgtgcccgacctgctctg	12	17	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:3021898C>T	uc002csj.3	+	3	1105	c.771C>T	c.(769-771)GGC>GGT	p.G257G	PAQR4_uc002csk.3_Silent_p.G218G|PAQR4_uc002csl.3_Silent_p.G183G|PAQR4_uc010uwm.1_Silent_p.G188G	NM_152341	NP_689554	Q8N4S7	PAQR4_HUMAN	progestin and adipoQ receptor family member IV	257	Helical; (Potential).					integral to membrane	receptor activity				0						TGCACGCCGGCGTCGTGCCCG	0.672													0	0	0	0.01441	0	42	64										T	3021898	C	T	3021898	2	4	50	1	0	0	0	0	0	0	0	1	11437	755	27	2		2	PAQR4	16	3021898	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1009327	3021898	87332855	100	14154										
TEKT5	146279	broad.mit.edu	37	chr16	10721530	10721530	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atgcagagggtgttggccttGatggcgagctcgtgctccag	16	9	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:10721530G>C	uc002czz.1	-	7	1440	c.1368C>G	c.(1366-1368)ATC>ATG	p.I456M		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	456					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						TGTTGGCCTTGATGGCGAGCT	0.647													0	0	0	0.01441	0	73	83										C	10721530	G	C	10721530	3	2	50	1	0	0	0	0	1	0	0	0	15753	1280	45	1	93	1	TEKT5	16	10721530	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	7699632	10721530	79633223	101	14155										
NPIP	9284	broad.mit.edu	37	chr16	15045471	15045471	+	Splice_Site	DEL	G	G	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ttccctcctttggccctacaGgtcagaatggcggcagtgga							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:15045471delG	uc002dcy.3	+	8	643	c.643_splice	c.e8-1	p.V215_splice	NPIP_uc002dcx.3_Splice_Site	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein						mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						TGGCCCTACAGGTCAGAATGG	0.483																		17	4	---	---								-	15045471	G	-	15045471	8	5	50	1	0	1	0	1	0	0	1	0	10584	1014	35	0	672	0	NPIP	16	15045471	Splice_Site	DEL	G	TCGA-DK-A1AG-01A-11D-A13W-08	4323941	15045471	75309282	102	14156										
HS3ST4	9951	broad.mit.edu	37	chr16	26146939	26146939	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cctccctctcctagaaatgtGatgcccaagactttggatgg	9	12	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:26146939G>A	uc002dof.2	+	2	1133	c.741G>A	c.(739-741)GTG>GTA	p.V247V		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	247	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		CTAGAAATGTGATGCCCAAGA	0.423													0	0	0	0.01892	0	25	30										A	26146939	G	A	26146939	2	1	50	1	0	0	0	0	0	0	0	1	7367	1277	45	1		1	HS3ST4	16	26146939	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	11101468	26146939	64207814	103	14157										
PRSS54	221191	broad.mit.edu	37	chr16	58320015	58320015	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ttatcaaagtcctcatggatGatgatggtattgactggata	10	5	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:58320015G>A	uc002enf.2	-	5	743	c.348C>T	c.(346-348)ATC>ATT	p.I116I	PRSS54_uc002eng.2_Silent_p.I116I|PRSS54_uc010vie.1_Silent_p.I17I	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	116	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCTCATGGATGATGATGGTAT	0.458													0	0	0	0.01441	0	72	111										A	58320015	G	A	58320015	2	1	50	1	0	0	0	0	0	0	0	1	12633	1280	45	1		1	PRSS54	16	58320015	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	32173076	58320015	32034738	104	14158										
PRSS54	221191	broad.mit.edu	37	chr16	58320044	58320044	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	attgactggatactctgtgtGagcaatcttgctaggatcca	10	8	2	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:58320044G>A	uc002enf.2	-	5	714	c.319C>T	c.(319-321)CAC>TAC	p.H107Y	PRSS54_uc002eng.2_Missense_Mutation_p.H107Y|PRSS54_uc010vie.1_Missense_Mutation_p.H8Y	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	107	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						TACTCTGTGTGAGCAATCTTG	0.453													0	0	0	0.01441	0	68	96										A	58320044	G	A	58320044	3	1	50	1	0	0	0	0	1	0	0	0	12633	1290	45	1	880	1	PRSS54	16	58320044	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	29	58320044	32034709	105	14159										
CDH1	999	broad.mit.edu	37	chr16	68847234	68847234	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	agtacaagggtcaggtgcctGagaacgaggctaacgtcgta	14	8	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr16:68847234G>A	uc002ewg.1	+	9	1280	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	386	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(5)|p.E386*(1)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TCAGGTGCCTGAGAACGAGGC	0.493			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.01441	0	60	67										A	68847234	G	A	68847234	3	1	50	1	0	0	0	0	1	0	0	0	3095	1291	45	1	1190	1	CDH1	16	68847234	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	10527190	68847234	21507519	106	14160										
KIAA0664	23277	broad.mit.edu	37	chr17	2605306	2605306	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ccaggctcttgagcaggtctCggacatggcgcacgtggatg	15	11	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr17:2605306C>T	uc002fuy.1	-	4	493	c.407G>A	c.(406-408)CGA>CAA	p.R136Q	KIAA0664_uc002fux.1_Missense_Mutation_p.R68Q	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	136							binding			breast(2)	2						GAGCAGGTCTCGGACATGGCG	0.622													0	0	0	0.01892	0	25	45										T	2605306	C	T	2605306	3	4	50	1	0	0	0	0	1	0	0	0	8189	884	31	1	3614	1	KIAA0664	17	2605306	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		2605306	78589904	107	14161										
AIPL1	23746	broad.mit.edu	37	chr17	6337283	6337283	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cacctcgtgcacccgcatggAggtaagcaggatctcccaga	11	14	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr17:6337283A>G	uc002gcp.2	-	2	327	c.232T>C	c.(232-234)TCC>CCC	p.S78P	AIPL1_uc002gcq.2_Intron|AIPL1_uc002gcr.2_Missense_Mutation_p.S78P|AIPL1_uc010clk.2_Missense_Mutation_p.S56P|AIPL1_uc010cll.2_Missense_Mutation_p.S78P|AIPL1_uc002gcs.2_Missense_Mutation_p.S78P	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	78	PPIase FKBP-type.				protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		ACCCGCATGGAGGTAAGCAGG	0.597													0	0	0	0.020292	0	13	48										G	6337283	A	G	6337283	3	3	50	1	0	0	0	0	1	0	0	0	436	304	11	5	942	5	AIPL1	17	6337283	Missense_Mutation	SNP	A	TCGA-DK-A1AG-01A-11D-A13W-08	3731977	6337283	74857927	108	14162										
AATF	26574	broad.mit.edu	37	chr17	35343960	35343960	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgaggtcattggtaggtcttCaggaagagttgcttttccag	13	6	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr17:35343960C>T	uc002hni.2	+	5	1128	c.877C>T	c.(877-879)CAG>TAG	p.Q293*	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	293	POLR2J binding.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				GGTAGGTCTTCAGGAAGAGTT	0.413													0	0	0	0.021523	0	23	70										T	35343960	C	T	35343960	4	4	50	1	0	0	0	0	0	1	0	0	25	827	29	1	895	1	AATF	17	35343960	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	29006677	35343960	45851250	109	14163										
CDC6	990	broad.mit.edu	37	chr17	38457718	38457718	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gttctcccttgtttcctaccAgttatatgaagcctacagta	6	11	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr17:38457718A>G	uc002huj.1	+	11	1663	c.1453_splice	c.e11-2	p.L485_splice		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein						cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						GTTTCCTACCAGTTATATGAA	0.453													0	0	0	0.01441	0	74	113										G	38457718	A	G	38457718	5	3	50	1	0	0	0	0	0	0	1	0	3083	202	7	5	1489	5	CDC6	17	38457718	Splice_Site	SNP	A	TCGA-DK-A1AG-01A-11D-A13W-08	3113758	38457718	42737492	110	14164										
RNF213	57674	broad.mit.edu	37	chr17	78318808	78318808	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ttgctcggttcctgaattatCagctcagagattgtgaggcc	11	9	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr17:78318808C>T	uc002jyh.1	+	4	1115	c.892C>T	c.(892-894)CAG>TAG	p.Q298*		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			CCTGAATTATCAGCTCAGAGA	0.498													0	0	0	0.01441	0	120	141										T	78318808	C	T	78318808	4	4	50	1	0	0	0	0	0	1	0	0	13477	827	29	1	7102	1	RNF213	17	78318808	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	39861090	78318808	2876402	111	14165										
PTPN2	5771	broad.mit.edu	37	chr18	12814236	12814236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ctccctttatacattttgctCcttctattatagccatgtat	3	11	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr18:12814236C>T	uc002krp.2	-	7	1018	c.824G>A	c.(823-825)GGA>GAA	p.G275E	PTPN2_uc002krl.2_Missense_Mutation_p.G275E|PTPN2_uc002krn.2_Missense_Mutation_p.G298E|PTPN2_uc002kro.2_Missense_Mutation_p.G275E|PTPN2_uc002krm.2_Missense_Mutation_p.G275E	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	275	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				ACATTTTGCTCCTTCTATTAT	0.323													0	0	0	0.009096	0	4	51										T	12814236	C	T	12814236	3	4	50	1	0	0	0	0	1	0	0	0	12785	855	30	1	461	1	PTPN2	18	12814236	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		12814236	65263012	112	14166										
INO80C	125476	broad.mit.edu	37	chr18	33077830	33077830	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtggccacaattggaatttgCgccgccatcgcactccgagt	11	13	0	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr18:33077830C>T	uc002kyy.3	-	1	126	c.9G>A	c.(7-9)GCG>GCA	p.A3A	INO80C_uc002kyw.1_Silent_p.A3A|INO80C_uc002kyx.3_5'Flank|INO80C_uc010dmt.2_Silent_p.A3A	NM_194281	NP_919257	Q6PI98	IN80C_HUMAN	Ies6-similar protein isoform 2	3					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|MLL1 complex					0						TTGGAATTTGCGCCGCCATCG	0.607													0	0	0	0.007413	0	15	23										T	33077830	C	T	33077830	2	4	50	1	0	0	0	0	0	0	0	1	7748	755	27	2		2	INO80C	18	33077830	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	20263594	33077830	44999418	113	14167										
DOT1L	84444	broad.mit.edu	37	chr19	2213964	2213964	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gagcaggacaaccgcgcgctCcgcggccagagcttgcagct	14	15	0	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:2213964C>A	uc002lvb.3	+	18	1812	c.1776C>A	c.(1774-1776)CTC>CTA	p.L592L	DOT1L_uc002lvc.1_5'UTR|uc002lvd.1_RNA|DOT1L_uc002lve.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	592						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGCGCGCTCCGCGGCCAGA	0.672													1	0	3.00063e-23	0.01441	3.11997e-23	59	61										A	2213964	C	A	2213964	2	1	50	1	0	0	0	0	0	0	0	1	4709	842	30	3		3	DOT1L	19	2213964	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08		2213964	56915019	114	14168										
DOT1L	84444	broad.mit.edu	37	chr19	2222507	2222507	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cgccgagccctgccgtccgtCgctggccttttcacacagcc	10	19	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:2222507C>T	uc002lvb.3	+	24	3375	c.3339C>T	c.(3337-3339)GTC>GTT	p.V1113V	DOT1L_uc002lvc.1_Silent_p.V407V|DOT1L_uc002lve.1_3'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1113						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCGTCCGTCGCTGGCCTTT	0.687													0	0	0	0.010771	0	37	40										T	2222507	C	T	2222507	2	4	50	1	0	0	0	0	0	0	0	1	4709	871	31	1		1	DOT1L	19	2222507	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	8543	2222507	56906476	115	14169										
TJP3	27134	broad.mit.edu	37	chr19	3747941	3747941	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gatggcgagggctacacagaCggcgagggggggccctacac	18	11	0	1	rs142779832		TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:3747941C>T	uc010xhv.1	+	18	2571	c.2571C>T	c.(2569-2571)GAC>GAT	p.D857D	TJP3_uc010xhs.1_Silent_p.D824D|TJP3_uc010xht.1_Silent_p.D788D|TJP3_uc010xhu.1_Silent_p.D833D|TJP3_uc010xhw.1_Silent_p.D843D	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	838						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTACACAGACGGCGAGGGGG	0.697													0	0	0	0.010818	0	31	60										T	3747941	C	T	3747941	2	4	50	1	0	0	0	0	0	0	0	1	15928	535	19	2		2	TJP3	19	3747941	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1525434	3747941	55381042	116	14170										
HDGFRP2	84717	broad.mit.edu	37	chr19	4501319	4501319	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	caaggtgtggctcctctgaaGacctgcacgagtgagtgtcc	13	11	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:4501319G>A	uc002mao.2	+	16	1999	c.1906G>A	c.(1906-1908)GAC>AAC	p.D636N	HDGFRP2_uc002map.2_Missense_Mutation_p.D636N|HDGFRP2_uc010dua.2_Intron|HDGFRP2_uc002maq.1_Missense_Mutation_p.D106N	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	636					transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						CTCCTCTGAAGACCTGCACGA	0.672													0	0	0	0.01441	0	50	81										A	4501319	G	A	4501319	3	1	50	1	0	0	0	0	1	0	0	0	7020	942	33	1	1968	1	HDGFRP2	19	4501319	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	753378	4501319	54627664	117	14171										
RFX2	5990	broad.mit.edu	37	chr19	6007099	6007099	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atgtggtcgcagctcctcatCcacctgaggatggggtcgca	13	12	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:6007099C>T	uc002meb.2	-	12	1595	c.1326G>A	c.(1324-1326)TGG>TGA	p.W442*	RFX2_uc002mec.2_Nonsense_Mutation_p.W417*|RFX2_uc002med.1_3'UTR	NM_000635	NP_000626	P48378	RFX2_HUMAN	regulatory factor X2 isoform a	442					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|ovary(1)|skin(1)	6						AGCTCCTCATCCACCTGAGGA	0.657													0	0	0	0.01441	0	67	98										T	6007099	C	T	6007099	4	4	50	1	0	0	0	0	0	1	0	0	13263	856	30	1	873	1	RFX2	19	6007099	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1505780	6007099	53121884	118	14172										
GPR108	56927	broad.mit.edu	37	chr19	6735965	6735965	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gaacccggctgagactgaacCccacctggtgggtggaaaaa	13	11	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:6735965C>G	uc002mfp.2	-	3	291	c.245G>C	c.(244-246)GGG>GCG	p.G82A	GPR108_uc002mfn.2_5'UTR|GPR108_uc002mfo.3_5'UTR|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	82						integral to membrane					0						GAGACTGAACCCCACCTGGTG	0.552											OREG0025202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.028581	0	14	47										G	6735965	C	G	6735965	3	3	50	1	0	0	0	0	1	0	0	0	6624	623	22	4	1450	4	GPR108	19	6735965	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	728866	6735965	52393018	119	14173										
MUC16	94025	broad.mit.edu	37	chr19	9076763	9076763	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggggtgctgtccatggtactCatacccacttctgggttggg	14	10	2	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:9076763C>T	uc002mkp.2	-	3	10887	c.10683G>A	c.(10681-10683)ATG>ATA	p.M3561I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3562	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCATGGTACTCATACCCACTT	0.542											OREG0007306	type=TRANSCRIPTION FACTOR BINDING SITE|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	0	0	0	0.024245	0	14	143										T	9076763	C	T	9076763	3	4	50	1	0	0	0	0	1	0	0	0	9973	826	29	1	33168	1	MUC16	19	9076763	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	2340798	9076763	50052220	120	14174										
ICAM5	7087	broad.mit.edu	37	chr19	10403332	10403332	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgagcgaacccagcgtctccGaggggcagatggtgacagta	15	10	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:10403332G>A	uc002mnu.3	+	5	1071	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	ICAM5_uc002mnv.3_Missense_Mutation_p.E211K	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	336	Extracellular (Potential).				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CAGCGTCTCCGAGGGGCAGAT	0.657													0	0	0	0.017118	0	36	55										A	10403332	G	A	10403332	3	1	50	1	0	0	0	0	1	0	0	0	7483	1059	37	1	1024	1	ICAM5	19	10403332	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	1326569	10403332	48725651	121	14175										
EPS15L1	58513	broad.mit.edu	37	chr19	16532171	16532171	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgggtgaggcccgagtgcatGaagatctccttcacctcctg	12	12	2	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:16532171G>A	uc002ndz.1	-	10	915	c.909C>T	c.(907-909)TTC>TTT	p.F303F	EPS15L1_uc002ndx.2_Silent_p.F303F|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.F193F|EPS15L1_uc010xpf.1_Silent_p.F206F|EPS15L1_uc002nea.1_Silent_p.F303F|EPS15L1_uc010eah.1_Silent_p.F303F|EPS15L1_uc002neb.1_Silent_p.F149F|EPS15L1_uc002nec.1_Silent_p.F303F	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	303	EH 3.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						CCGAGTGCATGAAGATCTCCT	0.577													0	0	0	0.01441	0	48	43										A	16532171	G	A	16532171	2	1	50	1	0	0	0	0	0	0	0	1	5193	1281	45	1		1	EPS15L1	19	16532171	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	6128839	16532171	42596812	122	14176										
FCHO1	23149	broad.mit.edu	37	chr19	17897393	17897393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tctctgccaggaacctggagGagaagcggctcacttggagg	15	10	2	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:17897393G>A	uc010ebb.2	+	26	2626	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	FCHO1_uc002nhg.3_Missense_Mutation_p.E813K|FCHO1_uc002nhh.2_Missense_Mutation_p.E813K|FCHO1_uc010xpw.1_Missense_Mutation_p.E763K|FCHO1_uc002nhi.2_Missense_Mutation_p.E269K|FCHO1_uc002nhj.2_Missense_Mutation_p.E157K	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	813										breast(1)	1						GAACCTGGAGGAGAAGCGGCT	0.493													0	0	0	0.00499	0	17	25										A	17897393	G	A	17897393	3	1	50	1	0	0	0	0	1	0	0	0	5787	1175	41	1	2531	1	FCHO1	19	17897393	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	1365222	17897393	41231590	123	14177										
ZNF155	7711	broad.mit.edu	37	chr19	44501575	44501575	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gattgtgggagacgctacaaGaggcgcttgaatctggatat	14	6	1	3			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:44501575G>C	uc002oxy.1	+	5	1771	c.1566G>C	c.(1564-1566)AAG>AAC	p.K522N	ZNF155_uc002oxz.1_Missense_Mutation_p.K522N|ZNF155_uc010xwt.1_Missense_Mutation_p.K533N|uc010ejc.1_RNA	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	522						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				GACGCTACAAGAGGCGCTTGA	0.303													0	0	0	0.023175	0	38	68										C	44501575	G	C	44501575	3	2	50	1	0	0	0	0	1	0	0	0	17733	933	33	1	1580	1	ZNF155	19	44501575	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	26604182	44501575	14627408	124	14178										
RPL18	6141	broad.mit.edu	37	chr19	49119427	49119427	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cctgccctgaggatgcggctGcgggcccggctggtcacgcg	17	15	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:49119427G>A	uc002pjq.1	-	5	363	c.330C>T	c.(328-330)CGC>CGT	p.R110R	FAM83E_uc002pjn.2_5'Flank|RPL18_uc002pjp.1_Silent_p.R58R|RPL18_uc010xzs.1_3'UTR	NM_000979	NP_000970	Q07020	RL18_HUMAN	ribosomal protein L18	110					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)		GGATGCGGCTGCGGGCCCGGC	0.667													0	0	0	0.01441	0	76	86										A	49119427	G	A	49119427	2	1	50	1	0	0	0	0	0	0	0	1	13564	1306	46	2		2	RPL18	19	49119427	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	4617852	49119427	10009556	125	14179										
PRKCG	5582	broad.mit.edu	37	chr19	54403679	54403679	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	accccgtcctccaggttctaCgcggcagaaatcgctatcgg	10	15	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:54403679C>T	uc002qcq.1	+	13	1662	c.1380C>T	c.(1378-1380)TAC>TAT	p.Y460Y	PRKCG_uc010yeg.1_Silent_p.Y460Y|PRKCG_uc010yeh.1_Silent_p.Y347Y	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	460	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCAGGTTCTACGCGGCAGAAA	0.597													0	0	0	0.00632	0	25	92										T	54403679	C	T	54403679	2	4	50	1	0	0	0	0	0	0	0	1	12512	547	19	2		2	PRKCG	19	54403679	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	5284252	54403679	4725304	126	14180										
LILRB3	11025	broad.mit.edu	37	chr19	54723027	54723029	+	In_Frame_Del	DEL	CGT	CGT	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgtgtttgctgtgacgctgaCgtcggaggaggaggaagagg					rs61734492	byFrequency	TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:54723027_54723029delCGT	uc002qef.1	-	8	1506_1508	c.1395_1397delACG	c.(1393-1398)CGACGT>CGT	p.465_466RR>R	LILRB3_uc002qee.1_In_Frame_Del_p.465_466RR>R|LILRB3_uc002qeh.1_In_Frame_Del_p.465_466RR>R|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_In_Frame_Del_p.465_466RR>R|LILRA6_uc002qek.1_In_Frame_Del_p.465_466RR>R|LILRB3_uc010erh.1_In_Frame_Del_p.482_483RR>R|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_In_Frame_Del_p.465_466RR>R|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_In_Frame_Del_p.465_466RR>R|LILRB3_uc002qep.1_In_Frame_Del_p.465_466RR>R|LILRB3_uc002qeq.1_In_Frame_Del_p.465_466RR>R|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_In_Frame_Del_p.465_466RR>R	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	465_466	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTGACGCTGACGTCggaggagga	0.498																		11	103	---	---								-	54723029	CGT	-	54723027	7	5	50	1	0	1	0	1	0	0	0	0	8792	536	19	0	525	0	LILRB3	19	54723027	In_Frame_Del	DEL	CGT	TCGA-DK-A1AG-01A-11D-A13W-08	319348	54723027	4405956	127	14181										
HSPBP1	23640	broad.mit.edu	37	chr19	55773977	55773977	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ggcaagaagccacctggtttCaccgatccatgctgtcgtcc	10	14	1	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:55773977C>G	uc002qjx.2	-	7	1327	c.1217G>C	c.(1216-1218)TGA>TCA	p.*406S	HSPBP1_uc002qjy.2_Nonstop_Mutation_p.*360S|HSPBP1_uc002qkb.2_3'UTR|HSPBP1_uc002qka.2_Nonstop_Mutation_p.*360S|HSPBP1_uc002qkd.2_Nonstop_Mutation_p.*360S|HSPBP1_uc002qkc.2_Nonstop_Mutation_p.*360S	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	406					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CACCTGGTTTCACCGATCCAT	0.622													0	0	0	0.024245	0	14	21										G	55773977	C	G	55773977	4	3	50	1	0	0	0	0	0	0	0	0	7426	837	29	1	4	1	HSPBP1	19	55773977	Nonstop_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1050950	55773977	3355006	128	14182										
ZNF667	63934	broad.mit.edu	37	chr19	56969551	56969551	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ccggcgtcttcttactggctCtaccatccagggtgctttcc	9	15	3	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:56969551C>A	uc002qnd.2	-	4	388	c.226G>T	c.(226-228)GAG>TAG	p.E76*	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Nonsense_Mutation_p.E76*|ZNF667_uc010etm.2_5'UTR	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	76	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CTTACTGGCTCTACCATCCAG	0.368													1	0	6.49762e-13	0.006122	6.68014e-13	18	40										A	56969551	C	A	56969551	4	1	50	1	0	0	0	0	0	1	0	0	18071	922	32	3	1614	3	ZNF667	19	56969551	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	1195574	56969551	2159432	129	14183										
ZNF548	147694	broad.mit.edu	37	chr19	57910375	57910375	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tttaagtacagtgccaatttCatgaaacatcagacagttca	6	8	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr19:57910375C>T	uc002qom.2	+	3	970	c.720C>T	c.(718-720)TTC>TTT	p.F240F	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Silent_p.F243F	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	240	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTGCCAATTTCATGAAACATC	0.393													0	0	0	0.014323	0	23	37										T	57910375	C	T	57910375	2	4	50	1	0	0	0	0	0	0	0	1	17977	825	29	1		1	ZNF548	19	57910375	Silent	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	940824	57910375	1218608	130	14184										
CENPB	1059	broad.mit.edu	37	chr20	3765860	3765860	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cctccccttcctcctcctctTcctctccttcaccctcttcc	0	25	4	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr20:3765860T>A	uc002wjk.2	-	1	1478	c.1271A>T	c.(1270-1272)GAA>GTA	p.E424V	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	424	Glu-rich (acidic).				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						ctcctcctcttcctctccttc	0.139													0	0	0	0.00499	0	18	37										A	3765860	T	A	3765860	3	1	50	1	0	0	0	0	1	0	0	0	3227	1783	62	5	532	5	CENPB	20	3765860	Missense_Mutation	SNP	T	TCGA-DK-A1AG-01A-11D-A13W-08		3765860	59259660	131	14185										
CHD6	84181	broad.mit.edu	37	chr20	40049283	40049283	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tgcactttctttccaaggttCttttaaaagctcatgcttca	5	10	4	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr20:40049283C>G	uc002xka.1	-	31	6170	c.5992G>C	c.(5992-5994)GAA>CAA	p.E1998Q		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1998					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTCCAAGGTTCTTTTAAAAGC	0.418													0	0	0	0.01441	0	57	75										G	40049283	C	G	40049283	3	3	50	1	0	0	0	0	1	0	0	0	3329	922	32	1	2183	1	CHD6	20	40049283	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	36283423	40049283	22976237	132	14186										
PCIF1	63935	broad.mit.edu	37	chr20	44569785	44569786	+	Missense_Mutation	DNP	CC	CC	GT													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	catcccgaagtggaactgctCcgctctcagctcatcctgaa							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr20:44569785_44569786CC>GT	uc002xqs.2	+	7	926_927	c.612_613CC>GT	c.(610-615)CTCCGC>CTGTGC	p.R205C		NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	205						nucleus				skin(1)	1						TGGAACTGCTCCGCTCTCAGCT	0.614													0	0	0	0.004672	0	67	97										GT	44569786	CC	GT	44569785	3	3	50	1	0	0	0	0	1	0	0	0	11580	842	30	1	630	1	PCIF1	20	44569785	Missense_Mutation	DNP	CC	TCGA-DK-A1AG-01A-11D-A13W-08	4520502	44569785	18455735	133	14187										
CDH22	64405	broad.mit.edu	37	chr20	44815269	44815269	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atgagggttgctgggagcttCaggcaccaggcggaaataga	16	7	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr20:44815269C>T	uc002xrm.2	-	9	2022	c.1621G>A	c.(1621-1623)GAA>AAA	p.E541K	CDH22_uc010ghk.1_Missense_Mutation_p.E541K	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	541	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CTGGGAGCTTCAGGCACCAGG	0.592													0	0	0	0.01441	0	60	67										T	44815269	C	T	44815269	3	4	50	1	0	0	0	0	1	0	0	0	3107	835	29	1	877	1	CDH22	20	44815269	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	245484	44815269	18210251	134	14188										
C20orf43	51507	broad.mit.edu	37	chr20	55049783	55049784	+	Missense_Mutation	DNP	GA	GA	AT													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ttctcttggacaaatctgcaGaaaaggctcttgggaaggca							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr20:55049783_55049784GA>AT	uc002xxt.2	+	3	321_322	c.214_215GA>AT	c.(214-216)GAA>ATA	p.E72I	C20orf43_uc010zzf.1_Missense_Mutation_p.E102I|C20orf43_uc002xxu.2_Missense_Mutation_p.E72I|C20orf43_uc002xxv.2_Missense_Mutation_p.E72I	NM_016407	NP_057491	Q9BY42	CT043_HUMAN	hypothetical protein LOC51507	72										ovary(1)	1			Colorectal(105;0.202)			CAAATCTGCAGAAAAGGCTCTT	0.381													0	0	0	0.004672	0	52	93										AT	55049784	GA	AT	55049783	3	1	50	1	0	0	0	0	1	0	0	0	2112	943	33	1	224	1	C20orf43	20	55049783	Missense_Mutation	DNP	GA	TCGA-DK-A1AG-01A-11D-A13W-08	10234514	55049783	7975737	135	14189										
CLDN14	23562	broad.mit.edu	37	chr21	37833619	37833619	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cacaggaggccggccaggatGaagagggtgccgccgaggat	18	10	0	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr21:37833619G>A	uc002yvk.1	-	2	517	c.375C>T	c.(373-375)TTC>TTT	p.F125F	CLDN14_uc002yvn.1_Silent_p.F125F|CLDN14_uc002yvo.1_Silent_p.F125F|CLDN14_uc002yvl.1_Silent_p.F125F|CLDN14_uc002yvm.1_Silent_p.F125F	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	125	Helical; (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CGGCCAGGATGAAGAGGGTGC	0.647													0	0	0	0.01441	0	78	146										A	37833619	G	A	37833619	2	1	50	1	0	0	0	0	0	0	0	1	3475	1281	45	1		1	CLDN14	21	37833619	Silent	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		37833619	10296276	136	14190										
HLCS	3141	broad.mit.edu	37	chr21	38126600	38126600	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	catgtcgaaggagttgccgtCcgggtgcacagtcacaacct	12	12	1	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr21:38126600C>T	uc010gnb.2	-	11	3329	c.2128G>A	c.(2128-2130)GAC>AAC	p.D710N	HLCS_uc002yvs.2_Missense_Mutation_p.D710N	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	710					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GAGTTGCCGTCCGGGTGCACA	0.637													0	0	0	0.00308	0	8	41										T	38126600	C	T	38126600	3	4	50	1	0	0	0	0	1	0	0	0	7213	855	30	1	56	1	HLCS	21	38126600	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	292981	38126600	10003295	137	14191										
DNMT3L	29947	broad.mit.edu	37	chr21	45681066	45681066	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tcccgggtgaaacggagcttGagagctcactggatcccacc	12	13	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr21:45681066G>C	uc002zeg.1	-	2	561	c.77C>G	c.(76-78)TCA>TGA	p.S26*	DNMT3L_uc002zeh.1_Nonsense_Mutation_p.S26*	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	26					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AACGGAGCTTGAGAGCTCACT	0.597													0	0	0	0.01441	0	108	148										C	45681066	G	C	45681066	4	2	50	1	0	0	0	0	0	1	0	0	4678	1294	45	1	1130	1	DNMT3L	21	45681066	Nonsense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	7554466	45681066	2448829	138	14192										
MYH9	4627	broad.mit.edu	37	chr22	36708249	36708249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ctcctcgtccagcagggccaGaatgcccggggggcctgcct	14	16	0	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr22:36708249G>C	uc003apg.2	-	14	1804	c.1573C>G	c.(1573-1575)CTG>GTG	p.L525V	MYH9_uc003aph.1_Missense_Mutation_p.L389V	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	525	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						AGCAGGGCCAGAATGCCCGGG	0.637			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.024245	0	12	138										C	36708249	G	C	36708249	3	2	50	1	0	0	0	0	1	0	0	0	10042	933	33	1	4421	1	MYH9	22	36708249	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08		36708249	14596317	139	14193										
SAMM50	25813	broad.mit.edu	37	chr22	44364695	44364695	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	atgttttgattgacacatgtCaaggtacatattgtggtgta	10	4	1	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chr22:44364695C>T	uc003bej.2	+	4	516	c.319C>T	c.(319-321)CAA>TAA	p.Q107*	SAMM50_uc011aqd.1_5'UTR	NM_015380	NP_056195	Q9Y512	SAM50_HUMAN	sorting and assembly machinery component 50	107					protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial sorting and assembly machinery complex	protein binding			skin(1)	1		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				TGACACATGTCAAGGTACATA	0.408													0	0	0	0.00499	0	16	83										T	44364695	C	T	44364695	4	4	50	1	0	0	0	0	0	1	0	0	13829	827	29	1	333	1	SAMM50	22	44364695	Nonsense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	7656446	44364695	6939871	140	14194										
KDM6A	7403	broad.mit.edu	37	chrX	44950110	44950110	+	Splice_Site	DEL	G	G	-													0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagctttttgaaatgattaaGtaagtcttttctaaaactgc							TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chrX:44950110delG	uc004dge.3	+	26	4253	c.3878_splice	c.e26+1	p.K1293_splice	KDM6A_uc011mkz.1_Splice_Site_p.K1345_splice|KDM6A_uc011mla.1_Splice_Site_p.K1248_splice|KDM6A_uc011mlb.1_Splice_Site_p.K1300_splice|KDM6A_uc011mlc.1_Splice_Site_p.K997_splice|KDM6A_uc011mld.1_Splice_Site_p.K932_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAATGATTAAGTAAGTCTTTT	0.348			D|N|F|S		renal|oesophageal SCC|MM													39	5	---	---								-	44950110	G	-	44950110	8	5	50	1	0	1	0	1	0	0	1	0	8137	1043	36	0	3981	0	KDM6A	23	44950110	Splice_Site	DEL	G	TCGA-DK-A1AG-01A-11D-A13W-08		44950110	110320450	141	14195										
SPIN4	139886	broad.mit.edu	37	chrX	62570437	62570437	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	tctcttatcgcggtgcagttCtagtccatacacactatctt	6	12	3	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chrX:62570437C>G	uc004dvf.2	-	1	782	c.262G>C	c.(262-264)GAA>CAA	p.E88Q		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	88					gamete generation					ovary(1)|lung(1)	2						CGGTGCAGTTCTAGTCCATAC	0.488													0	0	0	0.001984	0	7	18										G	62570437	C	G	62570437	3	3	50	1	0	0	0	0	1	0	0	0	15055	922	32	1	491	1	SPIN4	23	62570437	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	17620327	62570437	92700123	142	14196										
TAF1	6872	broad.mit.edu	37	chrX	70621446	70621446	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	ttctgccccctctattatcaAacaaatgcgccaccttccaa	3	16	3	0			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chrX:70621446A>G	uc004dzu.3	+	25	3903	c.3852A>G	c.(3850-3852)CAA>CAG	p.Q1284Q	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Silent_p.Q1305Q|TAF1_uc004dzv.3_Silent_p.Q458Q	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	1284					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				TCTATTATCAAACAAATGCGC	0.438													0	0	0	0.028581	0	17	60										G	70621446	A	G	70621446	2	3	50	1	0	0	0	0	0	0	0	1	15510	11	1	5		5	TAF1	23	70621446	Silent	SNP	A	TCGA-DK-A1AG-01A-11D-A13W-08	8051009	70621446	84649114	143	14197										
ITM2A	9452	broad.mit.edu	37	chrX	78616969	78616969	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	cataagtttgaggcagatatCtgccactctaaaaatcaaaa	6	8	3	2			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chrX:78616969C>T	uc004edh.2	-	5	895	c.560G>A	c.(559-561)AGA>AAA	p.R187K	ITM2A_uc011mqr.1_Missense_Mutation_p.R143K	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	187	BRICHOS.					integral to membrane	protein binding			lung(2)	2						AGGCAGATATCTGCCACTCTA	0.264													0	0	0	0.008291	0	11	26										T	78616969	C	T	78616969	3	4	50	1	0	0	0	0	1	0	0	0	7912	913	32	1	239	1	ITM2A	23	78616969	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	7995523	78616969	76653591	144	14198										
MCTS1	28985	broad.mit.edu	37	chrX	119739341	119739341	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	gtattaagaatcaattgataGagcaatttccaggtattgaa	8	4	1	4			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chrX:119739341G>A	uc004esx.2	+	2	439	c.91G>A	c.(91-93)GAG>AAG	p.E31K	MCTS1_uc011mub.1_Missense_Mutation_p.E32K	NM_014060	NP_054779	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1 isoform 1	31					cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding				0						TCAATTGATAGAGCAATTTCC	0.338													0	0	0	0.01441	0	75	9										A	119739341	G	A	119739341	3	1	50	1	0	0	0	0	1	0	0	0	9402	943	33	1	115	1	MCTS1	23	119739341	Missense_Mutation	SNP	G	TCGA-DK-A1AG-01A-11D-A13W-08	41122372	119739341	35531219	145	14199										
F8	2157	broad.mit.edu	37	chrX	154194885	154194885	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.452054794520548	66	1.49458561605867e-23	3.80624483857014	5.23469569873282	3.10106023671767	0.391060318583126	0.619973675802517	49	aagatcatcatcatagtcttCcgcttcttcattatttttca	3	10	7	1			TCGA-DK-A1AG-01A-11D-A13W-08	TCGA-DK-A1AG-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7d2a22eb-7344-4cba-ad7d-94c3f9ef3d7c	709c4655-20e7-46e3-b4c1-920c180abd6f	g.chrX:154194885C>G	uc004fmt.2	-	8	1258	c.1087G>C	c.(1087-1089)GAA>CAA	p.E363Q		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	363					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCATAGTCTTCCGCTTCTTCA	0.413													0	0	0	0.011902	0	44	6										G	154194885	C	G	154194885	3	3	50	1	0	0	0	0	1	0	0	0	5350	864	30	1	6072	1	F8	23	154194885	Missense_Mutation	SNP	C	TCGA-DK-A1AG-01A-11D-A13W-08	34455544	154194885	1075675	146	14200										
DNAJC16	23341	broad.mit.edu	37	chr1	15870967	15870967	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctaggggcacacagcacgccCtctatcctaggaatcattaa	8	13	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:15870967C>T	uc001aws.2	+	5	768	c.648C>T	c.(646-648)CCC>CCT	p.P216P	DNAJC16_uc001awr.1_Silent_p.P216P|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	216	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACAGCACGCCCTCTATCCTAG	0.478													0	0	0	0.013726	0	33	24										T	15870967	C	T	15870967	2	4	51	1	0	0	0	0	0	0	0	1	4635	668	24	2		2	DNAJC16	1	15870967	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		15870967	233379654	1	14201										
C1orf64	149563	broad.mit.edu	37	chr1	16332663	16332663	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ccaggccagggccaccctgcCgctctgcagagggtctgtgg	15	15	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:16332663C>T	uc001axn.2	+	2	400	c.332C>T	c.(331-333)CCG>CTG	p.P111L		NM_178840	NP_849162	Q8NEQ6	CA064_HUMAN	hypothetical protein LOC149563	111										breast(2)	2		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		GCCACCCTGCCGCTCTGCAGA	0.647													0	0	0	0.004482	0	8	67										T	16332663	C	T	16332663	3	4	51	1	0	0	0	0	1	0	0	0	2054	652	23	2	338	2	C1orf64	1	16332663	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	461696	16332663	232917958	2	14202										
PLA2G2E	30814	broad.mit.edu	37	chr1	20246922	20246922	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gtcacactcgcaggtcagccGctggcaggtggtcctgccgg	15	14	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:20246922G>A	uc001bct.1	-	4	365	c.307C>T	c.(307-309)CGG>TGG	p.R103W		NM_014589	NP_055404	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE precursor	103					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGTCAGCCGCTGGCAGGTG	0.592													0	0	0	0.013537	0	11	57										A	20246922	G	A	20246922	3	1	51	1	0	0	0	0	1	0	0	0	11998	1086	38	2	125	2	PLA2G2E	1	20246922	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	3914259	20246922	229003699	3	14203										
ARID1A	8289	broad.mit.edu	37	chr1	27099361	27099361	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atggaagtgactccacattcCagaagcggaattccatgact	9	10	0	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:27099361C>T	uc001bmv.1	+	14	3971	c.3598C>T	c.(3598-3600)CAG>TAG	p.Q1200*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1199*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1200*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q817*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q46*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1200					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTCCACATTCCAGAAGCGGAA	0.458			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.003954	0	27	31										T	27099361	C	T	27099361	4	4	51	1	0	0	0	0	0	1	0	0	913	595	21	2	3652	2	ARID1A	1	27099361	Nonsense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	6852439	27099361	222151260	4	14204										
BAI2	576	broad.mit.edu	37	chr1	32205620	32205620	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cacgacacggagcaggtgcaCagagccaggggacacctggg	16	12	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:32205620C>T	uc001btn.2	-	14	2428	c.2074G>A	c.(2074-2076)GTG>ATG	p.V692M	BAI2_uc010ogo.1_Missense_Mutation_p.V334M|BAI2_uc010ogp.1_Missense_Mutation_p.V625M|BAI2_uc010ogq.1_Missense_Mutation_p.V692M|BAI2_uc001bto.2_Missense_Mutation_p.V692M|BAI2_uc001btq.1_Missense_Mutation_p.V625M|BAI2_uc010ogr.1_Missense_Mutation_p.C501Y	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	692	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AGCAGGTGCACAGAGCCAGGG	0.587													0	0	0	0.010729	0	11	54										T	32205620	C	T	32205620	3	4	51	1	0	0	0	0	1	0	0	0	1299	478	17	2	2763	2	BAI2	1	32205620	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	5106259	32205620	217045001	5	14205										
GJA9	81025	broad.mit.edu	37	chr1	39340782	39340782	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	taagtgtggaaatctcattaGaaagtacagtttcctgttca	8	6	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:39340782G>C	uc001cct.1	-	2	1270	c.989C>G	c.(988-990)TCT>TGT	p.S330C	RRAGC_uc001ccr.2_5'Flank|MYCBP_uc001ccs.2_5'Flank	NM_030772	NP_110399	P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	330	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			AATCTCATTAGAAAGTACAGT	0.313													0	0	0	0.000602	0	5	77										C	39340782	G	C	39340782	3	2	51	1	0	0	0	0	1	0	0	0	6406	942	33	1	562	1	GJA9	1	39340782	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	7135162	39340782	209909839	6	14206										
PTPRF	5792	broad.mit.edu	37	chr1	44071029	44071029	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cagcccccgacctcctgcctCacaagccgctgcctgcctct	7	22	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:44071029C>T	uc001cjr.2	+	18	3644	c.3304C>T	c.(3304-3306)CAC>TAC	p.H1102Y	PTPRF_uc001cjs.2_Missense_Mutation_p.H1093Y|PTPRF_uc001cju.2_Missense_Mutation_p.H480Y|PTPRF_uc009vwt.2_Missense_Mutation_p.H662Y|PTPRF_uc001cjv.2_Missense_Mutation_p.H562Y|PTPRF_uc001cjw.2_Missense_Mutation_p.H328Y	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1102	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCTCCTGCCTCACAAGCCGCT	0.632													0	0	0	0.008291	0	10	43										T	44071029	C	T	44071029	3	4	51	1	0	0	0	0	1	0	0	0	12801	826	29	1	3366	1	PTPRF	1	44071029	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	4730247	44071029	205179592	7	14207										
LRRIQ3	127255	broad.mit.edu	37	chr1	74507499	74507499	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggaaaaaaatgttgttttttCtctctcaatactgcattatt	5	6	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:74507499C>A	uc001dfy.3	-	7	1308	c.1116G>T	c.(1114-1116)GAG>GAT	p.E372D	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	372										ovary(2)	2						GTTGTTTTTTCTCTCTCAATA	0.338													1	0	9.16793e-09	0.00499	1.04934e-08	14	51										A	74507499	C	A	74507499	3	1	51	1	0	0	0	0	1	0	0	0	9030	912	32	3	766	3	LRRIQ3	1	74507499	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	30436470	74507499	174743122	8	14208										
POGZ	23126	broad.mit.edu	37	chr1	151378506	151378506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gtcgaagccaacggcgaataCgtcgctggggatttcggaag	15	9	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:151378506C>T	uc001eyd.1	-	19	3311	c.3005G>A	c.(3004-3006)CGT>CAT	p.R1002H	POGZ_uc001eye.1_Missense_Mutation_p.R949H|POGZ_uc010pdb.1_Missense_Mutation_p.R993H|POGZ_uc001eyf.1_Missense_Mutation_p.R958H|POGZ_uc010pdc.1_Missense_Mutation_p.R940H|POGZ_uc009wmv.1_Missense_Mutation_p.R907H|POGZ_uc010pdd.1_Missense_Mutation_p.R493H	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1002					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACGGCGAATACGTCGCTGGGG	0.512													0	0	0	0.012319	0	22	199										T	151378506	C	T	151378506	3	4	51	1	0	0	0	0	1	0	0	0	12186	536	19	2	1231	2	POGZ	1	151378506	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	76871007	151378506	97872115	9	14209										
TCHH	7062	broad.mit.edu	37	chr1	152081768	152081768	+	Frame_Shift_Del	DEL	T	T	-													0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttgggacttcctgtcgcgccTtttggcttccttttgctctt							TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:152081768delT	uc001ezp.2	-	2	3925	c.3925delA	c.(3925-3927)AGGfs	p.R1309fs	TCHH_uc009wne.1_Frame_Shift_Del_p.R1309fs	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1309	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCGCGCCTTTTGGCTTCC	0.547																		7	544	---	---								-	152081768	T	-	152081768	7	5	51	1	0	1	0	1	0	0	0	0	15697	1608	56	0	1910	0	TCHH	1	152081768	Frame_Shift_Del	DEL	T	TCGA-DK-A2HX-01A-12D-A18F-08	703262	152081768	97168853	10	14210										
SPTA1	6708	broad.mit.edu	37	chr1	158596663	158596663	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	accacatcagccttccagttGaattcctgaaaggcataatc	6	12	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:158596663G>A	uc001fst.1	-	41	5998	c.5799C>T	c.(5797-5799)TTC>TTT	p.F1933F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1933	Spectrin 19.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTTCCAGTTGAATTCCTGAA	0.458													0	0	0	0.010818	0	27	136										A	158596663	G	A	158596663	2	1	51	1	0	0	0	0	0	0	0	1	15115	1281	45	1		1	SPTA1	1	158596663	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	6514895	158596663	90653958	11	14211										
SPTA1	6708	broad.mit.edu	37	chr1	158646079	158646079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctctgctttagcacataactCcttcacctttgggatgaaaa	6	11	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:158646079C>T	uc001fst.1	-	8	1163	c.964G>A	c.(964-966)GAG>AAG	p.E322K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	322	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCACATAACTCCTTCACCTTT	0.438													0	0	0	0.010504	0	19	122										T	158646079	C	T	158646079	3	4	51	1	0	0	0	0	1	0	0	0	15115	864	30	1	6475	1	SPTA1	1	158646079	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	49416	158646079	90604542	12	14212										
DHX9	1660	broad.mit.edu	37	chr1	182841625	182841625	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atgggaggacttacccagttCaaggtaatattgtgggggtg	15	5	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:182841625C>T	uc001gpr.2	+	15	1874	c.1711C>T	c.(1711-1713)CAA>TAA	p.Q571*	DHX9_uc001gps.2_Nonsense_Mutation_p.Q357*	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	571					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TTACCCAGTTCAAGGTAATAT	0.358													0	0	0	0.00308	0	7	109										T	182841625	C	T	182841625	4	4	51	1	0	0	0	0	0	1	0	0	4516	827	29	1	1765	1	DHX9	1	182841625	Nonsense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	24195546	182841625	66408996	13	14213										
LHX9	56956	broad.mit.edu	37	chr1	197890578	197890578	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctgaccacgggcgaccatttCggcatgaaggacagcctggt	13	12	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:197890578C>T	uc001guk.1	+	3	959	c.522C>T	c.(520-522)TTC>TTT	p.F174F	LHX9_uc001gui.1_Silent_p.F165F|LHX9_uc001guj.1_Silent_p.F180F	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	174	LIM zinc-binding 2.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GCGACCATTTCGGCATGAAGG	0.612													0	0	0	0.001855	0	12	45										T	197890578	C	T	197890578	2	4	51	1	0	0	0	0	0	0	0	1	8777	883	31	1		1	LHX9	1	197890578	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	15048953	197890578	51360043	14	14214										
PTPN14	5784	broad.mit.edu	37	chr1	214557839	214557839	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tctgtatgcaggatccccctCttcatctggcgcatgactgt	9	13	4	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:214557839C>G	uc001hkk.1	-	13	1630	c.1359G>C	c.(1357-1359)AAG>AAC	p.K453N	PTPN14_uc010pty.1_Missense_Mutation_p.K354N	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	453					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGATCCCCCTCTTCATCTGGC	0.572													0	0	0	0.010771	0	45	171										G	214557839	C	G	214557839	3	3	51	1	0	0	0	0	1	0	0	0	12783	912	32	1	2232	1	PTPN14	1	214557839	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	16667261	214557839	34692782	15	14215										
TRIM11	81559	broad.mit.edu	37	chr1	228589812	228589812	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gcctgggcttggaacagcaaCgcatcctgcatctgcttccg	11	14	1	0	rs148386528		TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:228589812C>T	uc001hss.2	-	2	714	c.459G>A	c.(457-459)GCG>GCA	p.A153A	TRIM11_uc010pvx.1_Silent_p.A153A|TRIM11_uc001hst.1_Silent_p.A153A	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	153	Potential.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				GGAACAGCAACGCATCCTGCA	0.627													0	0	0	0.009096	0	4	26										T	228589812	C	T	228589812	2	4	51	1	0	0	0	0	0	0	0	1	16484	523	19	2		2	TRIM11	1	228589812	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	14031973	228589812	20660809	16	14216										
RYR2	6262	broad.mit.edu	37	chr1	237729962	237729962	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aggccggacggtggtattttGaatttgagacggtcactgct	14	7	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:237729962G>T	uc001hyl.1	+	28	3430	c.3310G>T	c.(3310-3312)GAA>TAA	p.E1104*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1104	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGGTATTTTGAATTTGAGAC	0.567													1	0	8.24728e-16	0.004656	9.85524e-16	26	124										T	237729962	G	T	237729962	4	4	51	1	0	0	0	0	0	1	0	0	13769	1291	45	3	3420	3	RYR2	1	237729962	Nonsense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	9140150	237729962	11520659	17	14217										
RYR2	6262	broad.mit.edu	37	chr1	237765404	237765404	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tttccagtttgagttgggaaGaataaaggtaataaaactta	9	3	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:237765404G>C	uc001hyl.1	+	35	4796	c.4676G>C	c.(4675-4677)AGA>ACA	p.R1559T		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1559	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGTTGGGAAGAATAAAGGTA	0.303													0	0	0	0.000602	0	5	35										C	237765404	G	C	237765404	3	2	51	1	0	0	0	0	1	0	0	0	13769	942	33	1	4814	1	RYR2	1	237765404	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	35442	237765404	11485217	18	14218										
ZNF672	79894	broad.mit.edu	37	chr1	249142538	249142538	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	acgtgcgtgtccaatctcaaCgtgcatcggcgcaaccatgc	10	14	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr1:249142538C>T	uc001iex.2	+	4	1760	c.1065C>T	c.(1063-1065)AAC>AAT	p.N355N		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	355	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CCAATCTCAACGTGCATCGGC	0.647													0	0	0	0.009096	0	4	22										T	249142538	C	T	249142538	2	4	51	1	0	0	0	0	0	0	0	1	18076	535	19	2		2	ZNF672	1	249142538	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	11377134	249142538	108083	19	14219										
C2orf28	51374	broad.mit.edu	37	chr2	27439745	27439745	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgcttatgttcttcgggattCtgggagccaccactctatcc	9	12	3	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr2:27439745C>T	uc002rjf.2	+	7	957	c.784C>T	c.(784-786)CTG>TTG	p.L262L	C2orf28_uc002rjg.2_Silent_p.L149L|C2orf28_uc002rjh.2_RNA|CAD_uc002rji.2_5'Flank|CAD_uc010eyw.2_5'Flank	NM_080592	NP_542159	Q6UW56	APR3_HUMAN	apoptosis related protein 3 isoform b	207	Helical; (Potential).					integral to membrane|plasma membrane				skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTCGGGATTCTGGGAGCCAC	0.502													0	0	0	0.005524	0	33	65										T	27439745	C	T	27439745	2	4	51	1	0	0	0	0	0	0	0	1	2160	912	32	1		1	C2orf28	2	27439745	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		27439745	215759628	20	14220										
SRD5A2	6716	broad.mit.edu	37	chr2	31754425	31754425	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggaaacaaagtgagaaaaatGcaaatgcaagtgctgggagg	14	4	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr2:31754425G>T	uc002rnw.1	-	5	721	c.650C>A	c.(649-651)GCA>GAA	p.A217E		NM_000348	NP_000339	P31213	S5A2_HUMAN	3-oxo-5 alpha-steroid 4-dehydrogenase 2	217	Helical; (Potential).				androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity				0	Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	TGAGAAAAATGCAAATGCAAG	0.458													1	0	1.5739e-10	0.004007	1.8346e-10	16	25										T	31754425	G	T	31754425	3	4	51	1	0	0	0	0	1	0	0	0	15138	1319	46	4	122	4	SRD5A2	2	31754425	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	4314680	31754425	211444948	21	14221										
PCBP1	5093	broad.mit.edu	37	chr2	70314888	70314888	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cgctcgccatggatgccggtGtgactgaaagtggactaaat	13	9	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr2:70314888G>A	uc002sgf.2	+	1	304	c.13G>A	c.(13-15)GTG>ATG	p.V5M	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	5					nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						GGATGCCGGTGTGACTGAAAG	0.587													0	0	0	0.013537	0	10	63										A	70314888	G	A	70314888	3	1	51	1	0	0	0	0	1	0	0	0	11500	1377	48	2	15	2	PCBP1	2	70314888	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	38560463	70314888	172884485	22	14222										
DNAH7	56171	broad.mit.edu	37	chr2	196664028	196664028	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	attgtaaggtacctggtcatCagcaaattttagaagggcag	11	6	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr2:196664028C>T	uc002utj.3	-	55	10446	c.10345G>A	c.(10345-10347)GAT>AAT	p.D3449N		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3449	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ACCTGGTCATCAGCAAATTTT	0.388													0	0	0	0.012319	0	21	90										T	196664028	C	T	196664028	3	4	51	1	0	0	0	0	1	0	0	0	4606	826	29	1	1773	1	DNAH7	2	196664028	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	126349140	196664028	46535345	23	14223										
SPEG	10290	broad.mit.edu	37	chr2	220337647	220337647	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cgtacacagtgcagcaccagGtgctgggctcggaccagtgg	15	12	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr2:220337647G>A	uc010fwg.2	+	16	3976	c.3976G>A	c.(3976-3978)GTG>ATG	p.V1326M		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1326	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCAGCACCAGGTGCTGGGCTC	0.662													0	0	0	0.00278	0	21	15										A	220337647	G	A	220337647	3	1	51	1	0	0	0	0	1	0	0	0	15035	1261	44	2	4050	2	SPEG	2	220337647	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	23673619	220337647	22861726	24	14224										
FARSB	10056	broad.mit.edu	37	chr2	223464733	223464733	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttctgtccagcagcccatgaAtgatctcaaacccaggattc	7	13	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr2:223464733A>G	uc002vne.1	-	16	1567	c.1532T>C	c.(1531-1533)ATT>ACT	p.I511T	FARSB_uc010zlq.1_Missense_Mutation_p.I531T|FARSB_uc002vnf.1_Missense_Mutation_p.I412T	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	511					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	CAGCCCATGAATGATCTCAAA	0.433													0	0	0	0.00278	0	24	67										G	223464733	A	G	223464733	3	3	51	1	0	0	0	0	1	0	0	0	5680	101	4	5	245	5	FARSB	2	223464733	Missense_Mutation	SNP	A	TCGA-DK-A2HX-01A-12D-A18F-08	3127086	223464733	19734640	25	14225										
CNTN4	152330	broad.mit.edu	37	chr3	3078912	3078912	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	acagcgaccgtggtgggtttGaacccttgggttgaatatga	14	7	0	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:3078912G>C	uc003bpc.2	+	17	2213	c.1992G>C	c.(1990-1992)TTG>TTC	p.L664F	CNTN4_uc003bpb.1_Missense_Mutation_p.L335F|CNTN4_uc003bpd.1_Missense_Mutation_p.L664F|CNTN4_uc003bpe.2_Missense_Mutation_p.L336F|CNTN4_uc003bpf.2_Missense_Mutation_p.L335F|CNTN4_uc003bpg.2_5'Flank	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	664	Fibronectin type-III 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TGGTGGGTTTGAACCCTTGGG	0.502													0	0	0	0.010729	0	12	293										C	3078912	G	C	3078912	3	2	51	1	0	0	0	0	1	0	0	0	3643	1281	45	1	2050	1	CNTN4	3	3078912	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		3078912	194943518	26	14226										
LMCD1	29995	broad.mit.edu	37	chr3	8590590	8590590	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cgtccaaagaagtggaatacGtaagtttctcccatgcttcc	8	11	1	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:8590590G>A	uc003bqq.2	+	4	837	c.723_splice	c.e4+1	p.Y241_splice	LMCD1_uc011atd.1_Splice_Site_p.Y168_splice|LMCD1_uc011ate.1_Splice_Site_p.Y129_splice|LMCD1_uc011atf.1_Splice_Site_p.Y168_splice	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1						positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AGTGGAATACGTAAGTTTCTC	0.572													0	0	0	0.001168	0	6	10										A	8590590	G	A	8590590	5	1	51	1	0	0	0	0	0	0	1	0	8844	1159	40	2	738	2	LMCD1	3	8590590	Splice_Site	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	5511678	8590590	189431840	27	14227										
RBMS3	27303	broad.mit.edu	37	chr3	30032585	30032585	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctccttagggtgttgttgctGatacctctccccagacagtg	10	12	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:30032585G>A	uc003cel.2	+	14	1422	c.1192G>A	c.(1192-1194)GAT>AAT	p.D398N	RBMS3_uc003cek.2_Missense_Mutation_p.D382N|RBMS3_uc010hfq.2_Missense_Mutation_p.D395N|RBMS3_uc003cem.2_Missense_Mutation_p.D380N|RBMS3_uc010hfr.2_Missense_Mutation_p.D382N	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	398						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TGTTGTTGCTGATACCTCTCC	0.488													0	0	0	0.009096	0	4	63										A	30032585	G	A	30032585	3	1	51	1	0	0	0	0	1	0	0	0	13150	1290	45	1	1289	1	RBMS3	3	30032585	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	21441995	30032585	167989845	28	14228										
PHF7	51533	broad.mit.edu	37	chr3	52456270	52456291	+	Frame_Shift_Del	DEL	TCTCAGACTTATATCAGCGCTA	TCTCAGACTTATATCAGCGCTA	-													0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggaactcgagccaggggcttTctcagacttatatcagcgct							TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:52456270_52456291delTCTCAGACTTATATCAGCGCTA	uc003ddy.2	+	9	1519_1540	c.713_734delTCTCAGACTTATATCAGCGCTA	c.(712-735)TTCTCAGACTTATATCAGCGCTATfs	p.F238fs	PHF7_uc003ddz.2_Intron	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	238_245						nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		CCAGGGGCTTTCTCAGACTTATATCAGCGCTATCAGCACTGT	0.495																		9	129	---	---								-	52456291	TCTCAGACTTATATCAGCGCTA	-	52456270	7	5	51	1	0	1	0	1	0	0	0	0	11839	1783	62	0	743	0	PHF7	3	52456270	Frame_Shift_Del	DEL	TCTCAGACTTATATCAGCGCTA	TCGA-DK-A2HX-01A-12D-A18F-08	22423685	52456270	145566160	29	14229										
ADAMTS9	56999	broad.mit.edu	37	chr3	64589991	64589991	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cagctgggggaggatgacatGatggtaattcacagtcctag	14	7	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:64589991G>T	uc003dmg.2	-	24	3523	c.3491C>A	c.(3490-3492)TCA>TAA	p.S1164*	ADAMTS9_uc011bfo.1_Nonsense_Mutation_p.S1136*|ADAMTS9_uc003dmh.1_Nonsense_Mutation_p.S993*|ADAMTS9_uc011bfp.1_Nonsense_Mutation_p.S75*	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1164	TSP type-1 6.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		AGGATGACATGATGGTAATTC	0.458													1	0	4.96729e-08	0.008871	5.65141e-08	16	73										T	64589991	G	T	64589991	4	4	51	1	0	0	0	0	0	1	0	0	273	1294	45	3	2380	3	ADAMTS9	3	64589991	Nonsense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	12133721	64589991	133432439	30	14230										
NEK11	79858	broad.mit.edu	37	chr3	130828651	130828651	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atgctcttcatttcagggccGagatctggacgataaaattc	9	9	4	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:130828651G>T	uc003eny.2	+	5	667	c.341G>T	c.(340-342)CGA>CTA	p.R114L	NEK11_uc003enx.2_Missense_Mutation_p.R114L|NEK11_uc003eoa.2_Missense_Mutation_p.R114L|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_5'UTR|NEK11_uc011bll.1_Missense_Mutation_p.R114L|NEK11_uc003enw.1_Missense_Mutation_p.R114L|NEK11_uc011blm.1_Missense_Mutation_p.R114L|NEK11_uc010hto.1_5'UTR	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	114	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						TTTCAGGGCCGAGATCTGGAC	0.333													1	0	7.03913e-09	0.013537	8.10566e-09	12	96										T	130828651	G	T	130828651	3	4	51	1	0	0	0	0	1	0	0	0	10323	1058	37	3	351	3	NEK11	3	130828651	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	66238660	130828651	67193779	31	14231										
SMC4	10051	broad.mit.edu	37	chr3	160137215	160137215	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gtttggttcatgatctctttCaaaaagttgaagaagcaaag	9	5	3	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr3:160137215C>T	uc003fdh.2	+	12	1854	c.1741C>T	c.(1741-1743)CAA>TAA	p.Q581*	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Nonsense_Mutation_p.Q345*|SMC4_uc003fdi.2_Nonsense_Mutation_p.Q556*|SMC4_uc003fdj.2_Nonsense_Mutation_p.Q581*|SMC4_uc010hwd.2_Nonsense_Mutation_p.Q581*|SMC4_uc003fdl.2_Nonsense_Mutation_p.Q284*	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	581	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGATCTCTTTCAAAAAGTTGA	0.323													0	0	0	0.001168	0	5	70										T	160137215	C	T	160137215	4	4	51	1	0	0	0	0	0	1	0	0	14785	827	29	1	1783	1	SMC4	3	160137215	Nonsense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	29308564	160137215	37885215	32	14232										
OTOP1	133060	broad.mit.edu	37	chr4	4190623	4190623	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aggttgaccacaattatccaGggttcaaagccaaagacaat	8	9	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr4:4190623G>A	uc003ghp.1	-	6	1776	c.1746C>T	c.(1744-1746)CCC>CCT	p.P582P		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	582	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CAATTATCCAGGGTTCAAAGC	0.463													0	0	0	0.008361	0	16	121										A	4190623	G	A	4190623	2	1	51	1	0	0	0	0	0	0	0	1	11305	987	35	2		2	OTOP1	4	4190623	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		4190623	186963653	33	14233										
ATP10D	57205	broad.mit.edu	37	chr4	47584075	47584075	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	catctggtcattgaaagcaaGagtttggtgagtggttttct	12	5	3	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr4:47584075G>A	uc003gxk.1	+	21	3911	c.3747G>A	c.(3745-3747)AAG>AAA	p.K1249K	ATP10D_uc003gxl.1_Silent_p.K497K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1249	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TTGAAAGCAAGAGTTTGGTGA	0.448													0	0	0	0.00499	0	16	125										A	47584075	G	A	47584075	2	1	51	1	0	0	0	0	0	0	0	1	1118	933	33	1		1	ATP10D	4	47584075	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	43393452	47584075	143570201	34	14234										
LRBA	987	broad.mit.edu	37	chr4	151729481	151729481	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	agcttaaatacctcatatttGaaaccggatcttgtgaaact	6	8	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr4:151729481G>C	uc010ipj.2	-	32	5849	c.5375C>G	c.(5374-5376)TCA>TGA	p.S1792*	LRBA_uc003ilt.3_Nonsense_Mutation_p.S451*|LRBA_uc003ilu.3_Nonsense_Mutation_p.S1792*	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1792						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CCTCATATTTGAAACCGGATC	0.279													0	0	0	0.007413	0	18	50										C	151729481	G	C	151729481	4	2	51	1	0	0	0	0	0	1	0	0	8931	1294	45	1	3324	1	LRBA	4	151729481	Nonsense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	104145406	151729481	39424795	35	14235										
SH3D19	152503	broad.mit.edu	37	chr4	152065413	152065413	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gttttgagagacaatatcttCattggcaattccatgaggca	9	7	2	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr4:152065413C>T	uc010ipl.1	-	12	2360	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K	SH3D19_uc003imb.2_Intron|SH3D19_uc003imc.2_Intron|SH3D19_uc003ime.2_Intron|SH3D19_uc010ipm.2_Intron	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	424	SH3 1.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				ACAATATCTTCATTGGCAATT	0.363													0	0	0	0.00245	0	14	183										T	152065413	C	T	152065413	3	4	51	1	0	0	0	0	1	0	0	0	14249	835	29	1	1142	1	SH3D19	4	152065413	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	335932	152065413	39088863	36	14236										
SH3D19	152503	broad.mit.edu	37	chr4	152086849	152086849	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgcagggagctgaaagggatCtaatgaaaaacatagtttat	11	4	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr4:152086849C>T	uc010ipl.1	-	8	1785	c.695_splice	c.e8-1	p.D232_splice	SH3D19_uc003imb.2_Missense_Mutation_p.D10N|SH3D19_uc003imc.2_Intron|SH3D19_uc003ime.2_Splice_Site_p.D232_splice|SH3D19_uc010ipm.2_Splice_Site_p.D232_splice	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a						cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TGAAAGGGATCTAATGAAAAA	0.393													0	0	0	0.008291	0	11	87										T	152086849	C	T	152086849	5	4	51	1	0	0	0	0	0	0	1	0	14249	927	32	1	1734	1	SH3D19	4	152086849	Splice_Site	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	21436	152086849	39067427	37	14237										
CDH12	1010	broad.mit.edu	37	chr5	21975425	21975425	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggtttcatcaatggtaaaaaCggtgccagcgccatctcctg	10	11	3	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:21975425C>A	uc010iuc.2	-	3	759	c.301G>T	c.(301-303)GTT>TTT	p.V101F	CDH12_uc011cno.1_Missense_Mutation_p.V101F|CDH12_uc003jgk.2_Missense_Mutation_p.V101F	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	101	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						ATGGTAAAAACGGTGCCAGCG	0.433										HNSCC(59;0.17)			1	0	5.18039e-06	0.00308	5.78985e-06	8	128										A	21975425	C	A	21975425	3	1	51	1	0	0	0	0	1	0	0	0	3098	536	19	4	2123	4	CDH12	5	21975425	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		21975425	158939835	38	14238										
RXFP3	51289	broad.mit.edu	37	chr5	33937955	33937955	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttcctgtgccaggtatacgcGttccctgtgagcgtgtgcct	12	12	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:33937955G>A	uc003jic.1	+	1	1467	c.1110G>A	c.(1108-1110)GCG>GCA	p.A370A		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	370	Helical; Name=7; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						AGGTATACGCGTTCCCTGTGA	0.617													0	0	0	0.003954	0	23	104										A	33937955	G	A	33937955	2	1	51	1	0	0	0	0	0	0	0	1	13761	1132	40	2		2	RXFP3	5	33937955	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	11962530	33937955	146977305	39	14239										
GAPT	202309	broad.mit.edu	37	chr5	57790716	57790716	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atatgaaaacacagggcagtCtaatttcgaggagcatatct	9	7	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:57790716C>G	uc003jro.1	+	3	747	c.353C>G	c.(352-354)TCT>TGT	p.S118C		NM_152687	NP_689900	Q8N292	GAPT_HUMAN	GRB2-binding adaptor protein, transmembrane	118					B cell activation	integral to membrane|plasma membrane					0						ACAGGGCAGTCTAATTTCGAG	0.398													0	0	0	0.003163	0	15	99										G	57790716	C	G	57790716	3	3	51	1	0	0	0	0	1	0	0	0	6238	913	32	1	355	1	GAPT	5	57790716	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	23852761	57790716	123124544	40	14240										
PDE4D	5144	broad.mit.edu	37	chr5	58270597	58270597	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	catcaaggggaatttcagtaGactctgagtcttgagtacaa	10	7	4	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:58270597G>C	uc003jsa.2	-	15	2496	c.2324C>G	c.(2323-2325)TCT>TGT	p.S775C	PDE4D_uc003jrx.2_Missense_Mutation_p.S639C|PDE4D_uc003jry.2_Missense_Mutation_p.S473C|PDE4D_uc003jrz.2_Missense_Mutation_p.S711C|PDE4D_uc003jsb.2_Missense_Mutation_p.S714C|PDE4D_uc003jrt.2_Missense_Mutation_p.S473C|PDE4D_uc003jru.2_Missense_Mutation_p.S551C|PDE4D_uc003jrv.2_Missense_Mutation_p.S645C|PDE4D_uc003jrw.2_Missense_Mutation_p.S653C|PDE4D_uc003jrs.2_Missense_Mutation_p.S484C	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	775					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	AATTTCAGTAGACTCTGAGTC	0.488													0	0	0	0.001168	0	6	362										C	58270597	G	C	58270597	3	2	51	1	0	0	0	0	1	0	0	0	11642	942	33	1	109	1	PDE4D	5	58270597	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	479881	58270597	122644663	41	14241										
MAST4	375449	broad.mit.edu	37	chr5	66459603	66459603	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gacctggaccgcgacaagctGaaggccaaggtggtggtgaa	16	9	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:66459603G>A	uc003jut.1	+	28	4097	c.4029G>A	c.(4027-4029)CTG>CTA	p.L1343L	MAST4_uc003juw.2_Silent_p.L1271L|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1535						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GCGACAAGCTGAAGGCCAAGG	0.607													0	0	0	0.004672	0	3	11										A	66459603	G	A	66459603	2	1	51	1	0	0	0	0	0	0	0	1	9327	1277	45	1		1	MAST4	5	66459603	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	8189006	66459603	114455657	42	14242										
CDK7	1022	broad.mit.edu	37	chr5	68548275	68548275	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gacatagatcagaagctaaaGatggtaagtatttcatgtaa	9	4	2	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:68548275G>C	uc003jvs.3	+	3	338	c.157G>C	c.(157-159)GAT>CAT	p.D53H	CDK7_uc010ixd.1_Missense_Mutation_p.D53H|CDK7_uc003jvt.3_Missense_Mutation_p.D12H|CDK7_uc003jvu.3_5'UTR	NM_001799	NP_001790	P50613	CDK7_HUMAN	cyclin-dependent kinase 7	53	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			lung(1)	1		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		AGAAGCTAAAGATGGTAAGTA	0.209								NER					0	0	0	0.004672	0	3	84										C	68548275	G	C	68548275	3	2	51	1	0	0	0	0	1	0	0	0	3149	942	33	1	167	1	CDK7	5	68548275	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	2088672	68548275	112366985	43	14243										
OTP	23440	broad.mit.edu	37	chr5	76932777	76932777	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggtgaagcgcgtccggtggcGcttctgcttctgttggccct	15	12	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:76932777G>T	uc003kfg.2	-	2	464	c.316C>A	c.(316-318)CGC>AGC	p.R106S		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	106	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		GTCCGGTGGCGCTTCTGCTTC	0.667													1	0	9.35349e-44	0.01441	1.13195e-43	76	83										T	76932777	G	T	76932777	3	4	51	1	0	0	0	0	1	0	0	0	11310	1087	38	4	669	4	OTP	5	76932777	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	8384502	76932777	103982483	44	14244										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139914968	139914968	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gttaccatccattgacccatCaggcagctccccatcttcct	5	17	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:139914968C>G	uc003lfs.1	+	30	6996	c.6872C>G	c.(6871-6873)TCA>TGA	p.S2291*	ANKHD1_uc003lfr.2_Nonsense_Mutation_p.S2291*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.S1030*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.S929*|ANKHD1_uc010jfl.2_Intron|ANKHD1-EIF4EBP3_uc003lfx.1_Nonsense_Mutation_p.S428*	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2291						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGACCCATCAGGCAGCTCC	0.473													0	0	0	0.013537	0	10	162										G	139914968	C	G	139914968	4	3	51	1	0	0	0	0	0	1	0	0	629	838	29	1	6990	1	ANKHD1-EIF4EBP3	5	139914968	Nonsense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	62982191	139914968	41000292	45	14245										
PCDHA11	56138	broad.mit.edu	37	chr5	140250655	140250655	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggtgaaggatcacggtgagcCggcgctgacggccacggcca	17	12	1	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:140250655C>T	uc003lia.2	+	1	2825	c.1967C>T	c.(1966-1968)CCG>CTG	p.P656L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.P656L	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	656	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGTGAGCCGGCGCTGACG	0.677													0	0	0	0.010729	0	12	68										T	140250655	C	T	140250655	3	4	51	1	0	0	0	0	1	0	0	0	11521	652	23	2	1969	2	PCDHA11	5	140250655	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	335687	140250655	40664605	46	14246										
CSF1R	1436	broad.mit.edu	37	chr5	149434896	149434896	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggatgccagggtagggattcAgccctgcaaaggccaagatc	14	10	1	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:149434896A>G	uc003lrl.2	-	19	2753	c.2558T>C	c.(2557-2559)CTG>CCG	p.L853P	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.L853P	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	853	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GTAGGGATTCAGCCCTGCAAA	0.507													0	0	0	0.004672	0	3	99										G	149434896	A	G	149434896	3	3	51	1	0	0	0	0	1	0	0	0	3932	188	7	5	372	5	CSF1R	5	149434896	Missense_Mutation	SNP	A	TCGA-DK-A2HX-01A-12D-A18F-08	9184241	149434896	31480364	47	14247										
PDGFRB	5159	broad.mit.edu	37	chr5	149513181	149513181	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgttgatggccttttcatccTgatggtcattcacactctcc	7	12	4	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:149513181T>C	uc003lro.2	-	6	1371	c.902A>G	c.(901-903)CAG>CGG	p.Q301R	PDGFRB_uc010jhd.2_Missense_Mutation_p.Q140R|PDGFRB_uc011dcg.1_Missense_Mutation_p.Q301R	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta	301	Extracellular (Potential).|Ig-like C2-type 3.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTTTTCATCCTGATGGTCATT	0.557			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								0	0	0	0.001984	0	5	319										C	149513181	T	C	149513181	3	2	51	1	0	0	0	0	1	0	0	0	11662	1580	55	5	2490	5	PDGFRB	5	149513181	Missense_Mutation	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08	78285	149513181	31402079	48	14248										
IL12B	3593	broad.mit.edu	37	chr5	158750185	158750185	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctggccagcatctccaaactCtttgacttggatggtcaggg	11	11	3	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr5:158750185C>G	uc003lxr.1	-	3	283	c.241G>C	c.(241-243)GAG>CAG	p.E81Q		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	81	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTCCAAACTCTTTGACTTGG	0.517													0	0	0	0.004672	0	3	61										G	158750185	C	G	158750185	3	3	51	1	0	0	0	0	1	0	0	0	7625	922	32	1	765	1	IL12B	5	158750185	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	9237004	158750185	22165075	49	14249										
TFAP2A	7020	broad.mit.edu	37	chr6	10410338	10410338	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tggccgggccagcctgggtgCtgcggctgcggctgggcgtg	21	12	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:10410338C>T	uc003myr.2	-	2	528	c.276G>A	c.(274-276)CAG>CAA	p.Q92Q	TFAP2A_uc003myq.2_Silent_p.Q86Q|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Silent_p.Q92Q|TFAP2A_uc003myt.2_Silent_p.Q88Q|TFAP2A_uc003myu.1_Silent_p.Q92Q|TFAP2A_uc003myv.1_Silent_p.Q78Q|TFAP2A_uc011dii.1_Silent_p.Q88Q|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	92	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGCCTGGGTGCTGCGGCTGCG	0.692													0	0	0	0.010729	0	10	61										T	10410338	C	T	10410338	2	4	51	1	0	0	0	0	0	0	0	1	15784	796	28	2		2	TFAP2A	6	10410338	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		10410338	160704729	50	14250										
DDR1	780	broad.mit.edu	37	chr6	30862337	30862337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttcacctctctgtccctgggGacactatcctcatcaacaac	5	16	4	0	rs145788270		TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:30862337G>A	uc003nrr.2	+	12	1661	c.1402G>A	c.(1402-1404)GAC>AAC	p.D468N	DDR1_uc010jse.2_Missense_Mutation_p.D468N|DDR1_uc003nrq.2_Missense_Mutation_p.D468N|DDR1_uc003nrs.2_Missense_Mutation_p.D468N|DDR1_uc003nrt.2_Missense_Mutation_p.D468N|DDR1_uc011dms.1_Missense_Mutation_p.D486N|DDR1_uc003nru.2_Missense_Mutation_p.D468N|DDR1_uc003nrv.2_Missense_Mutation_p.D468N|DDR1_uc003nrw.1_Intron|DDR1_uc003nry.1_RNA|DDR1_uc003nrx.1_Intron|DDR1_uc003nrz.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	468	Cytoplasmic (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	TGTCCCTGGGGACACTATCCT	0.627													0	0	0	0.001168	0	6	101										A	30862337	G	A	30862337	3	1	51	1	0	0	0	0	1	0	0	0	4336	1174	41	1	1440	1	DDR1	6	30862337	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	20451999	30862337	140252730	51	14251										
C6orf81	221481	broad.mit.edu	37	chr6	35716341	35716341	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tccaacttcctaaacctgttCcagcccacacagtcagggag	7	15	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:35716341C>G	uc003ola.2	+	6	825	c.798C>G	c.(796-798)TTC>TTG	p.F266L	C6orf81_uc003olb.1_Intron	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	239							binding			ovary(1)	1						TAAACCTGTTCCAGCCCACAC	0.488													0	0	0	0.001984	0	6	61										G	35716341	C	G	35716341	3	3	51	1	0	0	0	0	1	0	0	0	2372	854	30	1	820	1	C6orf81	6	35716341	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	4854004	35716341	135398726	52	14252										
CDKN1A	1026	broad.mit.edu	37	chr6	36651987	36651988	+	Frame_Shift_Ins	INS	-	-	T													0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gagccgcgactgtgatgcgcINStaatggcgggctgcatccag							TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:36651987_36651988insT	uc003omm.3	+	2	231_232	c.109_110insT	c.(109-111)CTAfs	p.L37fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.L71fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.L37fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.L37fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	37	C4-type (Potential).				cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						CTGTGATGCGCTAATGGCGGGC	0.663									Multiple_Endocrine_Neoplasia_type_1									12	46	---	---								T	36651988	-	T	36651987	7	5	51	1	0	1	1	0	0	0	0	0	3158	796	28	0	111	0	CDKN1A	6	36651987	Frame_Shift_Ins	INS	-	TCGA-DK-A2HX-01A-12D-A18F-08	935646	36651987	134463080	53	14253										
TDRD6	221400	broad.mit.edu	37	chr6	46660917	46660917	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cctttagcaattgttgacttGaaaagcaaaggtaaaagtat	8	5	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:46660917G>C	uc003oyj.2	+	1	5052	c.5052G>C	c.(5050-5052)TTG>TTC	p.L1684F	TDRD6_uc010jze.2_Missense_Mutation_p.L1678F	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1684					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TTGTTGACTTGAAAAGCAAAG	0.303													0	0	0	0.000602	0	5	34										C	46660917	G	C	46660917	3	2	51	1	0	0	0	0	1	0	0	0	15731	1281	45	1	5054	1	TDRD6	6	46660917	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	10008930	46660917	124454150	54	14254										
COL19A1	1310	broad.mit.edu	37	chr6	70909320	70909320	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctatacatgaagagaggatgGctgtattcctatcccagctc	9	10	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:70909320G>A	uc003pfc.1	+	49	3220	c.3103G>A	c.(3103-3105)GCT>ACT	p.A1035T		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1035					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AGAGAGGATGGCTGTATTCCT	0.413													0	0	0	0.003163	0	16	38										A	70909320	G	A	70909320	3	1	51	1	0	0	0	0	1	0	0	0	3676	1203	42	2	3293	2	COL19A1	6	70909320	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	24248403	70909320	100205747	55	14255										
CLVS2	134829	broad.mit.edu	37	chr6	123332247	123332247	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gactggagtaacttcactttCaagcaagcctctaaactcac	6	12	4	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:123332247C>A	uc003pzi.1	+	3	1376	c.507C>A	c.(505-507)TTC>TTA	p.F169L		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	169	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACTTCACTTTCAAGCAAGCCT	0.413													1	0	0.000274275	0.004482	0.000302978	9	58										A	123332247	C	A	123332247	3	1	51	1	0	0	0	0	1	0	0	0	3572	825	29	3	513	3	CLVS2	6	123332247	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	52422927	123332247	47782820	56	14256										
LAMA2	3908	broad.mit.edu	37	chr6	129691064	129691064	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgtcacctcagcgggccccaGagaggcttattcagctggca	12	13	3	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:129691064G>A	uc003qbn.2	+	34	4993	c.4888G>A	c.(4888-4890)GAG>AAG	p.E1630K	LAMA2_uc003qbo.2_Missense_Mutation_p.E1630K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1630	Domain II and I.|Potential.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCGGGCCCCAGAGAGGCTTAT	0.458													0	0	0	0.012319	0	20	50										A	129691064	G	A	129691064	3	1	51	1	0	0	0	0	1	0	0	0	8606	943	33	1	5022	1	LAMA2	6	129691064	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	6358817	129691064	41424003	57	14257										
TAAR1	134864	broad.mit.edu	37	chr6	132966336	132966336	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aaagggtccatgactgtacaGataaagaaagggcaccagca	11	8	0	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr6:132966336G>T	uc003qdm.1	-	1	807	c.807C>A	c.(805-807)ATC>ATA	p.I269I		NM_138327	NP_612200	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	269	Helical; Name=6; (Potential).					plasma membrane					0	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	TGACTGTACAGATAAAGAAAG	0.368													1	0	1.64293e-13	0.00333	1.93887e-13	24	33										T	132966336	G	T	132966336	2	4	51	1	0	0	0	0	0	0	0	1	15486	932	33	3		3	TAAR1	6	132966336	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	3275272	132966336	38148731	58	14258										
MAD1L1	8379	broad.mit.edu	37	chr7	2259077	2259077	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	agttccgagatcctccccttCagtgcgttgatggtctaaaa	9	11	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr7:2259077C>T	uc003slh.1	-	6	752	c.486G>A	c.(484-486)CTG>CTA	p.L162L	MAD1L1_uc003slf.1_Silent_p.L162L|MAD1L1_uc003slg.1_Silent_p.L162L|MAD1L1_uc010ksh.1_Silent_p.L162L|MAD1L1_uc003sli.1_Silent_p.L70L|MAD1L1_uc010ksi.1_Silent_p.L115L|MAD1L1_uc010ksj.2_Silent_p.L162L	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	162	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TCCTCCCCTTCAGTGCGTTGA	0.602													0	0	0	0.000602	0	5	26										T	2259077	C	T	2259077	2	4	51	1	0	0	0	0	0	0	0	1	9147	813	29	1		1	MAD1L1	7	2259077	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		2259077	156879586	59	14259										
TSGA14	95681	broad.mit.edu	37	chr7	130039926	130039926	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tcttccagataatattctatCttttttaagtcttctggggt	6	7	5	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr7:130039926C>G	uc003vpz.2	-	10	974	c.927G>C	c.(925-927)AAG>AAC	p.K309N	TSGA14_uc003vpy.2_Missense_Mutation_p.K71N|TSGA14_uc010lmf.2_Missense_Mutation_p.K106N|TSGA14_uc003vqa.2_Intron|TSGA14_uc011kpg.1_Intron	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	309					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					AATATTCTATCTTTTTTAAGT	0.453													0	0	0	0.01441	0	76	107										G	130039926	C	G	130039926	3	3	51	1	0	0	0	0	1	0	0	0	16617	912	32	1	202	1	TSGA14	7	130039926	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	127780849	130039926	29098737	60	14260										
TAS2R5	54429	broad.mit.edu	37	chr7	141490167	141490167	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctcctctccccagccatgctGagcgctggcctaggactgct	10	17	1	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr7:141490167G>A	uc003vwr.1	+	1	151	c.6G>A	c.(4-6)CTG>CTA	p.L2L		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	2	Helical; Name=1; (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					CAGCCATGCTGAGCGCTGGCC	0.512													0	0	0	0.000602	0	4	112										A	141490167	G	A	141490167	2	1	51	1	0	0	0	0	0	0	0	1	15580	1277	45	1		1	TAS2R5	7	141490167	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	11450241	141490167	17648496	61	14261										
TRPV5	56302	broad.mit.edu	37	chr7	142605800	142605800	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctgctgctctgggacgcggtCcgggacagggaggaagttgg	19	9	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr7:142605800C>T	uc003wby.1	-	15	2334	c.2070G>A	c.(2068-2070)CGG>CGA	p.R690R		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	690	Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GGGACGCGGTCCGGGACAGGG	0.582													0	0	0	0.000602	0	5	105										T	142605800	C	T	142605800	2	4	51	1	0	0	0	0	0	0	0	1	16596	842	30	1		1	TRPV5	7	142605800	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	1115633	142605800	16532863	62	14262										
GIMAP1	170575	broad.mit.edu	37	chr7	150417944	150417944	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctggccctgctgctggggggCgcgctcctgttctgggtgct	17	13	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr7:150417944C>T	uc003whq.2	+	3	939	c.852C>T	c.(850-852)GGC>GGT	p.G284G	GIMAP1_uc003whp.2_Silent_p.G292G	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	284	Helical; Anchor for type IV membrane protein; (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCTGGGGGGCGCGCTCCTGT	0.687													0	0	0	0.009096	0	4	21										T	150417944	C	T	150417944	2	4	51	1	0	0	0	0	0	0	0	1	6379	755	27	2		2	GIMAP1	7	150417944	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	7812144	150417944	8720719	63	14263										
MLL3	58508	broad.mit.edu	37	chr7	151864343	151864343	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tggcagtacgttgtttagctGaaagggccttcttagatttt	11	6	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr7:151864343G>A	uc003wla.2	-	42	9857	c.9638C>T	c.(9637-9639)TCA>TTA	p.S3213L	MLL3_uc003wkz.2_Missense_Mutation_p.S2274L|MLL3_uc003wky.2_Missense_Mutation_p.S722L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3213	Gln-rich.|Potential.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGTTTAGCTGAAAGGGCCTT	0.443			N		medulloblastoma								0	0	0	0.008291	0	10	101										A	151864343	G	A	151864343	3	1	51	1	0	0	0	0	1	0	0	0	9622	1294	45	1	5169	1	MLL3	7	151864343	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	1446399	151864343	7274320	64	14264										
USP17L2	377630	broad.mit.edu	37	chr8	11996072	11996072	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctgctactcagaggaagcttCttcctgggagcaagctgtct	11	11	3	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:11996072C>T	uc003wvc.1	-	1	198	c.198G>A	c.(196-198)AAG>AAA	p.K66K	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	66				K -> E (in Ref. 1; AAR91701).	apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						GAGGAAGCTTCTTCCTGGGAG	0.567													0	0	0	0.00308	0	8	94										T	11996072	C	T	11996072	2	4	51	1	0	0	0	0	0	0	0	1	17045	912	32	1		1	USP17L2	8	11996072	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		11996072	134367950	65	14265										
SLC7A2	6542	broad.mit.edu	37	chr8	17406258	17406258	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cagctgttaatattctcgtcCttctgtttgtgatggttgct	9	8	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:17406258C>T	uc011kyc.1	+	4	773	c.604C>T	c.(604-606)CTT>TTT	p.L202F	SLC7A2_uc011kyd.1_Missense_Mutation_p.L242F|SLC7A2_uc011kye.1_Missense_Mutation_p.L242F|SLC7A2_uc011kyf.1_Missense_Mutation_p.L202F	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	202	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TATTCTCGTCCTTCTGTTTGT	0.368													0	0	0	0.001984	0	5	124										T	17406258	C	T	17406258	3	4	51	1	0	0	0	0	1	0	0	0	14697	681	24	2	738	2	SLC7A2	8	17406258	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	5410186	17406258	128957764	66	14266										
NAT1	9	broad.mit.edu	37	chr8	18079981	18079981	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggagttaatttctgggaaggAtcagcctcaggtgccttgtg	14	7	3	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:18079981A>G	uc010ltd.2	+	5	792	c.425A>G	c.(424-426)GAT>GGT	p.D142G	NAT1_uc003wyt.2_Missense_Mutation_p.D204G|NAT1_uc003wyu.2_Missense_Mutation_p.D142G|NAT1_uc003wyv.2_Missense_Mutation_p.D142G|NAT1_uc010ltc.2_Missense_Mutation_p.D142G|NAT1_uc003wys.2_Missense_Mutation_p.D204G|NAT1_uc003wyr.2_Missense_Mutation_p.D142G|NAT1_uc003wyq.2_Missense_Mutation_p.D142G|NAT1_uc011kyl.1_Missense_Mutation_p.D142G	NM_001160179	NP_001153651	P18440	ARY1_HUMAN	N-acetyltransferase 1 isoform a	142					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity				0				Colorectal(111;0.0519)|COAD - Colon adenocarcinoma(73;0.208)		TCTGGGAAGGATCAGCCTCAG	0.473													0	0	0	0.009096	0	4	121										G	18079981	A	G	18079981	3	3	51	1	0	0	0	0	1	0	0	0	10173	333	12	5	621	5	NAT1	8	18079981	Missense_Mutation	SNP	A	TCGA-DK-A2HX-01A-12D-A18F-08	673723	18079981	128284041	67	14267										
NRG1	3084	broad.mit.edu	37	chr8	32616847	32616847	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tacgtatctaaaaacgtcatCtccagtgagcatattgttga	7	8	3	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:32616847C>G	uc003xiv.2	+	10	1471	c.954C>G	c.(952-954)ATC>ATG	p.I318M	NRG1_uc011lbf.1_Missense_Mutation_p.I315M|NRG1_uc010lvo.2_Missense_Mutation_p.I315M|NRG1_uc003xiu.2_Missense_Mutation_p.I323M|NRG1_uc003xiw.2_Missense_Mutation_p.I315M|NRG1_uc003xit.2_Missense_Mutation_p.I318M|NRG1_uc010lvr.2_Missense_Mutation_p.I60M|NRG1_uc010lvs.2_Missense_Mutation_p.I60M|NRG1_uc010lvp.2_Missense_Mutation_p.I272M|NRG1_uc010lvq.2_Missense_Mutation_p.I255M|NRG1_uc011lbg.1_Missense_Mutation_p.I164M|NRG1_uc011lbh.1_Missense_Mutation_p.I161M|NRG1_uc003xja.2_Missense_Mutation_p.I129M	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	318	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		AAAACGTCATCTCCAGTGAGC	0.403													0	0	0	0.00499	0	17	63										G	32616847	C	G	32616847	3	3	51	1	0	0	0	0	1	0	0	0	10647	903	32	1	2588	1	NRG1	8	32616847	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	14536866	32616847	113747175	68	14268										
PI15	51050	broad.mit.edu	37	chr8	75757469	75757469	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gatgtcctatgagatgttttGgtcccatgtgcacacattat	9	8	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:75757469G>A	uc003yal.2	+	4	678	c.499G>A	c.(499-501)GGT>AGT	p.G167S	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.G167S	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	167						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GAGATGTTTTGGTCCCATGTG	0.368													0	0	0	0.00278	0	19	97										A	75757469	G	A	75757469	3	1	51	1	0	0	0	0	1	0	0	0	11868	1348	47	2	509	2	PI15	8	75757469	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	43140622	75757469	70606553	69	14269										
NBN	4683	broad.mit.edu	37	chr8	90993117	90993117	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgcaaccaaaggctcatactCtattctgtaaatgagaataa	6	8	3	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:90993117C>T	uc003yej.1	-	4	435	c.325G>A	c.(325-327)GAG>AAG	p.E109K	NBN_uc003yei.1_Missense_Mutation_p.E27K|NBN_uc011lgb.1_Missense_Mutation_p.E109K	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	109	BRCT.				cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			GGCTCATACTCTATTCTGTAA	0.328								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.000602	0	5	20										T	90993117	C	T	90993117	3	4	51	1	0	0	0	0	1	0	0	0	10191	922	32	1	1991	1	NBN	8	90993117	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	15235648	90993117	55370905	70	14270										
LRP12	29967	broad.mit.edu	37	chr8	105503599	105503599	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggtactctgactagggacaaCctcatctccatctgctgaga	9	12	4	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:105503599C>T	uc003yma.2	-	7	1977	c.1882G>A	c.(1882-1884)GTT>ATT	p.V628I	LRP12_uc003ymb.2_Missense_Mutation_p.V609I|LRP12_uc003ylz.2_Missense_Mutation_p.V34I	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	628	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTAGGGACAACCTCATCTCCA	0.428													0	0	0	0.003163	0	14	67										T	105503599	C	T	105503599	3	4	51	1	0	0	0	0	1	0	0	0	8954	507	18	2	701	2	LRP12	8	105503599	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	14510482	105503599	40860423	71	14271										
ZFPM2	23414	broad.mit.edu	37	chr8	106573710	106573710	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	acttgaataataattctttgGtatgtggatattccgagatg	9	4	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr8:106573710G>A	uc003ymd.2	+	4	443	c.420_splice	c.e4+1	p.L140_splice		NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2						blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TAATTCTTTGGTATGTGGATA	0.408													0	0	0	0.010504	0	21	16										A	106573710	G	A	106573710	5	1	51	1	0	0	0	0	0	0	1	0	17655	1275	44	2	435	2	ZFPM2	8	106573710	Splice_Site	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	1070111	106573710	39790312	72	14272										
FREM1	158326	broad.mit.edu	37	chr9	14746434	14746434	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cagtagcctgagtgctggtgCcacccggctggacaggattt	14	11	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr9:14746434C>T	uc003zlm.2	-	35	6761	c.6171G>A	c.(6169-6171)TGG>TGA	p.W2057*	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Nonsense_Mutation_p.W593*	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2057					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AGTGCTGGTGCCACCCGGCTG	0.493													0	0	0	0.009096	0	4	135										T	14746434	C	T	14746434	4	4	51	1	0	0	0	0	0	1	0	0	6044	740	26	2	380	2	FREM1	9	14746434	Nonsense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		14746434	126466997	73	14273										
FREM1	158326	broad.mit.edu	37	chr9	14808019	14808019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tggaaaggacgcatgaagtgGaacagatggattgggtccat	15	5	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr9:14808019G>A	uc003zlm.2	-	17	3597	c.3007C>T	c.(3007-3009)CCA>TCA	p.P1003S	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1003	CSPG 6.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GCATGAAGTGGAACAGATGGA	0.463													0	0	0	0.008871	0	20	149										A	14808019	G	A	14808019	3	1	51	1	0	0	0	0	1	0	0	0	6044	1174	41	1	3666	1	FREM1	9	14808019	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	61585	14808019	126405412	74	14274										
TMEM215	401498	broad.mit.edu	37	chr9	32784282	32784282	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	caccgtctctgggatgaaagGggagactttgggaaacatcc	13	9	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr9:32784282G>A	uc003zri.3	+	2	466	c.101G>A	c.(100-102)GGG>GAG	p.G34E		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	34						integral to membrane					0						GGGATGAAAGGGGAGACTTTG	0.592													0	0	0	0.00278	0	25	64										A	32784282	G	A	32784282	3	1	51	1	0	0	0	0	1	0	0	0	16135	1232	43	2	103	2	TMEM215	9	32784282	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	17976263	32784282	108429149	75	14275										
NFX1	4799	broad.mit.edu	37	chr9	33342807	33342807	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gttgtggccttcataggtgtGaagaaccttgtcatcgtgga	13	7	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr9:33342807G>A	uc003zsq.2	+	13	2240	c.2179G>A	c.(2179-2181)GAA>AAA	p.E727K	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.E727K|NFX1_uc003zso.2_Missense_Mutation_p.E727K|NFX1_uc003zsp.1_Missense_Mutation_p.E727K|NFX1_uc010mjr.1_Missense_Mutation_p.E728K|NFX1_uc003zsr.2_Missense_Mutation_p.E728K	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	727	NF-X1-type 6.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TCATAGGTGTGAAGAACCTTG	0.398													0	0	0	0.004007	0	14	29										A	33342807	G	A	33342807	3	1	51	1	0	0	0	0	1	0	0	0	10387	1291	45	1	2229	1	NFX1	9	33342807	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	558525	33342807	107870624	76	14276										
ODF2	4957	broad.mit.edu	37	chr9	131243909	131243909	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gcactgctgaaacggctggcGgaggccgactcagagaaagc	15	11	1	2	rs150687097		TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr9:131243909G>A	uc011mbd.1	+	9	1205	c.894G>A	c.(892-894)GCG>GCA	p.A298A	ODF2_uc011maz.1_Silent_p.A298A|ODF2_uc011mba.1_Silent_p.A83A|ODF2_uc010myb.2_Silent_p.A274A|ODF2_uc011mbb.1_Silent_p.A232A|ODF2_uc011mbc.1_Silent_p.A217A|ODF2_uc004bva.2_Silent_p.A251A|ODF2_uc004bvb.2_Silent_p.A274A|ODF2_uc011mbe.1_Silent_p.A293A|ODF2_uc004bvc.2_Silent_p.A274A|ODF2_uc010myc.2_Silent_p.A241A|ODF2_uc011mbf.1_Silent_p.A279A|ODF2_uc004bvd.3_Silent_p.A298A|ODF2_uc004bve.2_Silent_p.A279A	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	298	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						AACGGCTGGCGGAGGCCGACT	0.483													0	0	0	0.000602	0	5	42										A	131243909	G	A	131243909	2	1	51	1	0	0	0	0	0	0	0	1	10827	1103	39	2		2	ODF2	9	131243909	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	97901102	131243909	9969522	77	14277										
FAM171A1	221061	broad.mit.edu	37	chr10	15325934	15325934	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cacgtaggcatgcttcgaggCggtgacaatcaactgactgc	12	11	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:15325934C>T	uc001iob.2	-	2	275	c.268G>A	c.(268-270)GCC>ACC	p.A90T		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	90	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						TGCTTCGAGGCGGTGACAATC	0.542													0	0	0	0.010729	0	12	181										T	15325934	C	T	15325934	3	4	51	1	0	0	0	0	1	0	0	0	5490	768	27	2	2432	2	FAM171A1	10	15325934	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		15325934	120208813	78	14278										
SLC39A12	221074	broad.mit.edu	37	chr10	18242228	18242228	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gtgcttccggacaaagctctCagtatcctgggtgccattgt	11	11	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:18242228C>T	uc001ipo.2	+	2	296	c.23C>T	c.(22-24)TCA>TTA	p.S8L	SLC39A12_uc001ipn.2_Missense_Mutation_p.S8L|SLC39A12_uc001ipp.2_Missense_Mutation_p.S8L|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	8	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						ACAAAGCTCTCAGTATCCTGG	0.502													0	0	0	0.008291	0	11	200										T	18242228	C	T	18242228	3	4	51	1	0	0	0	0	1	0	0	0	14615	838	29	1	25	1	SLC39A12	10	18242228	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	2916294	18242228	117292519	79	14279										
RRP12	23223	broad.mit.edu	37	chr10	99148350	99148350	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	attcactgcccttgaggactGagcatactccatgctgggca	10	12	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:99148350G>A	uc001knf.2	-	7	924	c.785C>T	c.(784-786)TCA>TTA	p.S262L	RRP12_uc009xvm.2_Intron|RRP12_uc010qou.1_Missense_Mutation_p.S201L|RRP12_uc009xvn.2_Missense_Mutation_p.S162L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	262						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CTTGAGGACTGAGCATACTCC	0.552													0	0	0	0.00308	0	8	41										A	99148350	G	A	99148350	3	1	51	1	0	0	0	0	1	0	0	0	13686	1294	45	1	3220	1	RRP12	10	99148350	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	80906122	99148350	36386397	80	14280										
SFXN2	118980	broad.mit.edu	37	chr10	104491933	104491933	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctgcggccataggcatcaccCaagtagttatttctcggatc	9	12	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:104491933C>T	uc001kwb.2	+	8	845	c.679C>T	c.(679-681)CAA>TAA	p.Q227*	SFXN2_uc001kwc.2_Intron|SFXN2_uc001kwd.2_Intron	NM_178858	NP_849189	Q96NB2	SFXN2_HUMAN	sideroflexin 2	227					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity				0		Colorectal(252;0.207)		Epithelial(162;4.53e-09)|all cancers(201;1.2e-07)|BRCA - Breast invasive adenocarcinoma(275;0.218)		AGGCATCACCCAAGTAGTTAT	0.532													0	0	0	0.004878	0	37	71										T	104491933	C	T	104491933	4	4	51	1	0	0	0	0	0	1	0	0	14195	595	21	2	705	2	SFXN2	10	104491933	Nonsense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	5343583	104491933	31042814	81	14281										
ITPRIP	85450	broad.mit.edu	37	chr10	106075629	106075629	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctccttttcggccgccagccGagccacctcctcctccaggc	8	21	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:106075629G>T	uc001kye.2	-	2	254	c.181C>A	c.(181-183)CGG>AGG	p.R61R	ITPRIP_uc001kyf.2_Silent_p.R61R|ITPRIP_uc001kyg.2_Silent_p.R61R	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	61	Potential.					plasma membrane					0						GCCGCCAGCCGAGCCACCTCC	0.662													1	0	1.40151e-16	0.010504	1.68536e-16	20	88										T	106075629	G	T	106075629	2	4	51	1	0	0	0	0	0	0	0	1	7923	1057	37	3		3	ITPRIP	10	106075629	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	1583696	106075629	29459118	82	14282										
ADD3	120	broad.mit.edu	37	chr10	111893106	111893106	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aaccatgagctgttttccaaGagcttcatctccatggaagt	8	10	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:111893106G>C	uc001kyt.3	+	16	2165	c.1851G>C	c.(1849-1851)AAG>AAC	p.K617N	ADD3_uc001kys.3_Missense_Mutation_p.K585N|ADD3_uc001kyu.2_Missense_Mutation_p.K617N|ADD3_uc001kyv.2_Missense_Mutation_p.K617N|ADD3_uc001kyw.2_Missense_Mutation_p.K585N|ADD3_uc001kyx.2_Missense_Mutation_p.K190N	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	617						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		TGTTTTCCAAGAGCTTCATCT	0.393													0	0	0	0.00245	0	14	90										C	111893106	G	C	111893106	3	2	51	1	0	0	0	0	1	0	0	0	306	933	33	1	1905	1	ADD3	10	111893106	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	5817477	111893106	23641641	83	14283										
FGFR2	2263	broad.mit.edu	37	chr10	123353267	123353267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	caactaaactgaaggagggcCgggccagggacaaggttgcc	15	10	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr10:123353267C>T	uc010qtk.1	-	2	712	c.65G>A	c.(64-66)CGG>CAG	p.R22Q	FGFR2_uc010qtg.1_Missense_Mutation_p.R22Q|FGFR2_uc010qth.1_Missense_Mutation_p.R22Q|FGFR2_uc010qti.1_Missense_Mutation_p.R22Q|FGFR2_uc010qtj.1_Missense_Mutation_p.R22Q|FGFR2_uc010qtl.1_Missense_Mutation_p.R22Q|FGFR2_uc010qtm.1_Missense_Mutation_p.R22Q|FGFR2_uc001lfl.3_Missense_Mutation_p.R22Q|FGFR2_uc001lfm.2_Missense_Mutation_p.R22Q|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Missense_Mutation_p.R41Q|FGFR2_uc010qto.1_Missense_Mutation_p.R41Q|FGFR2_uc001lfo.1_Missense_Mutation_p.R41Q|FGFR2_uc010qtp.1_Missense_Mutation_p.R41Q|FGFR2_uc010qtq.1_Missense_Mutation_p.R41Q	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	22	Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GAAGGAGGGCCGGGCCAGGGA	0.502		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00278	0	21	45										T	123353267	C	T	123353267	3	4	51	1	0	0	0	0	1	0	0	0	5866	652	23	2	2724	2	FGFR2	10	123353267	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	11460161	123353267	12181480	84	14284										
C11orf2	738	broad.mit.edu	37	chr11	64875072	64875072	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gacaccatccggaagatgaaGaacgatttccggaagatgga	12	8	0	4			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr11:64875072G>A	uc001ocr.1	+	3	418	c.378G>A	c.(376-378)AAG>AAA	p.K126K	C11orf2_uc001ocs.1_Silent_p.K2K	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	126	Potential.				lipid transport|protein transport	Golgi apparatus|integral to membrane					0						GGAAGATGAAGAACGATTTCC	0.622													0	0	0	0.001855	0	13	45										A	64875072	G	A	64875072	2	1	51	1	0	0	0	0	0	0	0	1	1633	933	33	1		1	C11orf2	11	64875072	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		64875072	70131444	85	14285										
PELI3	246330	broad.mit.edu	37	chr11	66241241	66241241	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aatggcggaccccagatggcCtgatggatggactgaccacc	13	12	0	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr11:66241241C>T	uc001oic.3	+	7	849	c.685C>T	c.(685-687)CTG>TTG	p.L229L	PELI3_uc001oib.2_Silent_p.L229L|PELI3_uc001oid.3_Silent_p.L205L|PELI3_uc001oie.3_Silent_p.L80L|PELI3_uc010rpd.1_Silent_p.L70L	NM_145065	NP_659502	Q8N2H9	PELI3_HUMAN	pellino 3 alpha isoform 1	229						cytosol	protein binding			ovary(1)	1						CCCAGATGGCCTGATGGATGG	0.657													0	0	0	0.004672	0	3	69										T	66241241	C	T	66241241	2	4	51	1	0	0	0	0	0	0	0	1	11723	680	24	2		2	PELI3	11	66241241	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	1366169	66241241	68765275	86	14286										
ACTN3	89	broad.mit.edu	37	chr11	66330384	66330384	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cagccgagactgacacgactGagcaagttgtagcttccttc	10	12	0	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr11:66330384G>C	uc001oio.1	+	21	2524	c.2506G>C	c.(2506-2508)GAG>CAG	p.E836Q	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	836					focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						TGACACGACTGAGCAAGTTGT	0.602													0	0	0	0.00308	0	8	109										C	66330384	G	C	66330384	3	2	51	1	0	0	0	0	1	0	0	0	206	1291	45	1	2584	1	ACTN3	11	66330384	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	89143	66330384	68676132	87	14287										
ARHGAP20	57569	broad.mit.edu	37	chr11	110486316	110486316	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atttgtccttttgttctggaGaactgcaatcaaagaaaatg	8	6	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr11:110486316G>A	uc001pkz.1	-	6	791	c.506C>T	c.(505-507)TCT>TTT	p.S169F	ARHGAP20_uc001pky.1_Missense_Mutation_p.S146F|ARHGAP20_uc009yyb.1_Missense_Mutation_p.S133F|ARHGAP20_uc001pla.1_Missense_Mutation_p.S133F	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	169	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TTGTTCTGGAGAACTGCAATC	0.299													0	0	0	0.008291	0	9	66										A	110486316	G	A	110486316	3	1	51	1	0	0	0	0	1	0	0	0	870	942	33	1	3113	1	ARHGAP20	11	110486316	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	44155932	110486316	24520200	88	14288										
TMPRSS13	84000	broad.mit.edu	37	chr11	117789394	117789394	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gcctggaggtgtaccagctgGagatgcctgggctggagatg	18	8	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr11:117789394G>A	uc001prs.1	-	2	274	c.181C>T	c.(181-183)CCA>TCA	p.P61S	TMPRSS13_uc009yzr.1_5'UTR|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.1_Missense_Mutation_p.P61S	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	61	4 X 5 AA repeats of T-P-P-G-R.|1-8.|12 X 5 AA repeats of A-S-P-A-[GLQR].|Cytoplasmic (Potential).|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GTACCAGCTGGAGATGCCTGG	0.697													0	0	0	0.00308	0	7	86										A	117789394	G	A	117789394	3	1	51	1	0	0	0	0	1	0	0	0	16242	1174	41	1	1570	1	TMPRSS13	11	117789394	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	7303078	117789394	17217122	89	14289										
LRP1	4035	broad.mit.edu	37	chr12	57597024	57597024	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cggccgctgcatcgcggggcGctggaaatgcgatggagacc	17	12	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr12:57597024G>T	uc001snd.2	+	69	11238	c.10772G>T	c.(10771-10773)CGC>CTC	p.R3591L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3591	LDL-receptor class A 27.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ATCGCGGGGCGCTGGAAATGC	0.672													1	0	0.00116845	0.001168	0.00126139	6	30										T	57597024	G	T	57597024	3	4	51	1	0	0	0	0	1	0	0	0	8951	1087	38	4	11046	4	LRP1	12	57597024	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		57597024	76254871	90	14290										
CPM	1368	broad.mit.edu	37	chr12	69265567	69265567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gaccagcccctctttaccttCcgatgctgtaataacagtca	6	14	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr12:69265567C>T	uc001sup.2	-	4	489	c.428G>A	c.(427-429)GGA>GAA	p.G143E	CPM_uc001sur.2_Missense_Mutation_p.G143E|CPM_uc001suq.2_Missense_Mutation_p.G143E	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	143					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			TCTTTACCTTCCGATGCTGTA	0.463													0	0	0	0.010504	0	19	100										T	69265567	C	T	69265567	3	4	51	1	0	0	0	0	1	0	0	0	3808	855	30	1	927	1	CPM	12	69265567	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	11668543	69265567	64586328	91	14291										
KITLG	4254	broad.mit.edu	37	chr12	88912549	88912550	+	Missense_Mutation	DNP	AC	AC	GA													0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttgtctatgatggaataattActcaagccttcagaaatatt							TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr12:88912549_88912550AC>GA	uc001tav.2	-	4	470_471	c.287_288GT>TC	c.(286-288)AGT>ATC	p.S96I	KITLG_uc009zsn.2_Missense_Mutation_p.S24I|KITLG_uc001taw.2_Missense_Mutation_p.S96I|KITLG_uc009zso.1_Intron	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	96	Extracellular (Potential).				cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1						TGGAATAATTACTCAAGCCTTC	0.376									Testicular_Cancer_Familial_Clustering_of				0	0	0	0.004672	0	15	34										GA	88912550	AC	GA	88912549	3	3	51	1	0	0	0	0	1	0	0	0	8330	388	14	5	557	5	KITLG	12	88912549	Missense_Mutation	DNP	AC	TCGA-DK-A2HX-01A-12D-A18F-08	19646982	88912549	44939346	92	14292										
SCYL2	55681	broad.mit.edu	37	chr12	100731227	100731227	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	caagagcaggcacagaagctGaaaagccagcagcctcttaa	10	11	1	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr12:100731227G>A	uc001thn.2	+	17	2138	c.2088G>A	c.(2086-2088)CTG>CTA	p.L696L	SCYL2_uc001thm.1_Silent_p.L696L	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	696	Potential.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						CACAGAAGCTGAAAAGCCAGC	0.378													0	0	0	0.001984	0	7	69										A	100731227	G	A	100731227	2	1	51	1	0	0	0	0	0	0	0	1	13948	1277	45	1		1	SCYL2	12	100731227	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	11818678	100731227	33120668	93	14293										
NCOR2	9612	broad.mit.edu	37	chr12	124821373	124821373	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cccggtgcgggtccgaggccGaggcaggtggcgccggcggg	22	13	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr12:124821373G>A	uc010tay.1	-	40	6227	c.6071C>T	c.(6070-6072)TCG>TTG	p.S2024L	NCOR2_uc010taz.1_Missense_Mutation_p.S2008L|NCOR2_uc010tax.1_Missense_Mutation_p.S135L	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2025					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GTCCGAGGCCGAGGCAGGTGG	0.652													0	0	0	0.006214	0	9	68										A	124821373	G	A	124821373	3	1	51	1	0	0	0	0	1	0	0	0	10236	1059	37	1	1543	1	NCOR2	12	124821373	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	24090146	124821373	9030522	94	14294										
AKAP11	11215	broad.mit.edu	37	chr13	42882729	42882729	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aagatgaaagcagcagttttCatcatctaagtgaaaggtaa	9	5	3	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr13:42882729C>T	uc001uys.1	+	9	5432	c.5257C>T	c.(5257-5259)CAT>TAT	p.H1753Y		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1753	Ser-rich.				intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CAGCAGTTTTCATCATCTAAG	0.348													0	0	0	0.008291	0	10	60										T	42882729	C	T	42882729	3	4	51	1	0	0	0	0	1	0	0	0	447	826	29	1	5283	1	AKAP11	13	42882729	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		42882729	72287149	95	14295										
PIBF1	10464	broad.mit.edu	37	chr13	73539485	73539485	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cattgaatcagtgcgtcagaGagattctaagattgattcac	9	7	4	5			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr13:73539485G>C	uc001vjc.2	+	15	2212	c.1907G>C	c.(1906-1908)AGA>ACA	p.R636T	PIBF1_uc001vjb.2_Missense_Mutation_p.R636T|PIBF1_uc010aep.2_Missense_Mutation_p.R95T	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	636						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GTGCGTCAGAGAGATTCTAAG	0.353													0	0	0	0.006214	0	9	95										C	73539485	G	C	73539485	3	2	51	1	0	0	0	0	1	0	0	0	11879	942	33	1	1961	1	PIBF1	13	73539485	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	30656756	73539485	41630393	96	14296										
RBM26	64062	broad.mit.edu	37	chr13	79945293	79945293	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atcttttttcctctcatcacGgcttctaaagaaatatgtga	5	9	4	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr13:79945293G>A	uc001vkz.2	-	5	435	c.421C>T	c.(421-423)CGT>TGT	p.R141C	RBM26_uc001vky.2_Missense_Mutation_p.R141C|RBM26_uc001vla.2_Missense_Mutation_p.R141C|RBM26_uc001vkx.2_5'Flank|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	141	Arg-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CTCTCATCACGGCTTCTAAAG	0.338													0	0	0	0.006214	0	10	118										A	79945293	G	A	79945293	3	1	51	1	0	0	0	0	1	0	0	0	13126	1116	39	2	2589	2	RBM26	13	79945293	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	6405808	79945293	35224585	97	14297										
DHRS7	51635	broad.mit.edu	37	chr14	60619882	60619882	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgggacattccaccattgttGaccagaatgtcgatctagtt	9	9	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr14:60619882G>A	uc001xes.2	-	4	592	c.408C>T	c.(406-408)GTC>GTT	p.V136V	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Silent_p.V86V|DHRS7_uc001xeu.2_Silent_p.V136V	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	136							binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		CACCATTGTTGACCAGAATGT	0.423													0	0	0	0.013537	0	13	48										A	60619882	G	A	60619882	2	1	51	1	0	0	0	0	0	0	0	1	4495	1277	45	1		1	DHRS7	14	60619882	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		60619882	46729658	98	14298										
PSEN1	5663	broad.mit.edu	37	chr14	73664744	73664744	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tttttctttttctagatttaGtggctgttttgtgtccgaaa	8	5	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr14:73664744G>A	uc001xnr.2	+	8	1059	c.775G>A	c.(775-777)GTG>ATG	p.V259M	PSEN1_uc001xnv.2_Missense_Mutation_p.V255M|PSEN1_uc010ark.2_Missense_Mutation_p.V255M|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	259	Helical; (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		TCTAGATTTAGTGGCTGTTTT	0.368													0	0	0	0.009096	0	4	34										A	73664744	G	A	73664744	3	1	51	1	0	0	0	0	1	0	0	0	12650	1029	36	2	797	2	PSEN1	14	73664744	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	13044862	73664744	33684796	99	14299										
RIN3	79890	broad.mit.edu	37	chr14	93125804	93125804	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atctacgactccatggccctCggcaacccaggtcagtgggc	11	15	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr14:93125804C>T	uc001yap.2	+	7	2477	c.2325C>T	c.(2323-2325)CTC>CTT	p.L775L	RIN3_uc010auk.2_Silent_p.L437L|RIN3_uc001yaq.2_Silent_p.L700L|RIN3_uc001yar.1_Silent_p.L437L|RIN3_uc001yas.1_Silent_p.L437L	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	775	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CCATGGCCCTCGGCAACCCAG	0.582													0	0	0	0.008291	0	10	108										T	93125804	C	T	93125804	2	4	51	1	0	0	0	0	0	0	0	1	13373	871	31	1		1	RIN3	14	93125804	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	19461060	93125804	14223736	100	14300										
HERC1	8925	broad.mit.edu	37	chr15	63984690	63984690	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tttttgattgaattgcttttGaagatacaactctgcgaaga	8	5	1	5			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr15:63984690G>C	uc002amp.2	-	31	5898	c.5750C>G	c.(5749-5751)TCA>TGA	p.S1917*		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1917					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						AATTGCTTTTGAAGATACAAC	0.403													0	0	0	0.000602	0	5	75										C	63984690	G	C	63984690	4	2	51	1	0	0	0	0	0	1	0	0	7057	1294	45	1	9027	1	HERC1	15	63984690	Nonsense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		63984690	38546702	101	14301										
CLPX	10845	broad.mit.edu	37	chr15	65447361	65447361	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cacttcgattagcaaggtctGcagcagctgcagcccttctg	10	13	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr15:65447361G>A	uc002aom.2	-	11	1442	c.1370C>T	c.(1369-1371)GCA>GTA	p.A457V	CLPX_uc010uiu.1_RNA	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	457					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						AGCAAGGTCTGCAGCAGCTGC	0.408													0	0	0	0.001855	0	14	58										A	65447361	G	A	65447361	3	1	51	1	0	0	0	0	1	0	0	0	3556	1319	46	2	547	2	CLPX	15	65447361	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	1462671	65447361	37084031	102	14302										
DENND4A	10260	broad.mit.edu	37	chr15	65983668	65983668	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gcttcctggttaattctattGagcataaatcccatcagtac	6	10	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr15:65983668G>A	uc002aph.2	-	22	3510	c.3132C>T	c.(3130-3132)CTC>CTT	p.L1044L	DENND4A_uc002api.2_Silent_p.L1087L|DENND4A_uc002apj.3_Silent_p.L1044L	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1044					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TAATTCTATTGAGCATAAATC	0.383													0	0	0	0.001168	0	5	57										A	65983668	G	A	65983668	2	1	51	1	0	0	0	0	0	0	0	1	4433	1277	45	1		1	DENND4A	15	65983668	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	536307	65983668	36547724	103	14303										
CORO2B	10391	broad.mit.edu	37	chr15	68987486	68987486	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttctcctctgcagacaggcaGgattgaacccaactacccca	7	15	2	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr15:68987486G>A	uc002arj.3	+	3	253	c.224G>A	c.(223-225)AGG>AAG	p.R75K	CORO2B_uc010bic.2_Missense_Mutation_p.R70K	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	75					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						CAGACAGGCAGGATTGAACCC	0.532													0	0	0	0.00333	0	24	87										A	68987486	G	A	68987486	3	1	51	1	0	0	0	0	1	0	0	0	3757	1000	35	2	234	2	CORO2B	15	68987486	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	3003818	68987486	33543906	104	14304										
NRG4	145957	broad.mit.edu	37	chr15	76254308	76254308	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	acgagctcctgtatagttttCaacgcacctacagaataaaa	6	10	1	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr15:76254308C>T	uc002bbo.2	-	4	296	c.112G>A	c.(112-114)GAA>AAA	p.E38K	NRG4_uc010bkm.1_RNA|NRG4_uc002bbn.2_RNA|NRG4_uc010bkn.2_RNA|NRG4_uc010bko.2_RNA|NRG4_uc002bbp.2_RNA	NM_138573	NP_612640	Q8WWG1	NRG4_HUMAN	neuregulin 4	38	Extracellular (Potential).|EGF-like.					extracellular region|integral to membrane|plasma membrane	growth factor activity				0						GTATAGTTTTCAACGCACCTA	0.388													0	0	0	0.008871	0	21	107										T	76254308	C	T	76254308	3	4	51	1	0	0	0	0	1	0	0	0	10650	835	29	1	247	1	NRG4	15	76254308	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	7266822	76254308	26277084	105	14305										
CHD2	1106	broad.mit.edu	37	chr15	93547859	93547859	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tttaaaagcctaaaagtggtGatgccaaatcttcgagtaaa	8	6	1	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr15:93547859G>T	uc002bsp.2	+	34	4866	c.4291G>T	c.(4291-4293)GAT>TAT	p.D1431Y	CHD2_uc002bso.1_Missense_Mutation_p.D1431Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1431					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TAAAAGTGGTGATGCCAAATC	0.403													1	0	0.00307968	0.00308	0.00330587	7	132										T	93547859	G	T	93547859	3	4	51	1	0	0	0	0	1	0	0	0	3325	1290	45	3	4425	3	CHD2	15	93547859	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	17293551	93547859	8983533	106	14306										
COG8	84342	broad.mit.edu	37	chr16	69373204	69373204	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atgaaggtcttgtagttagcGaaggccaagtcgcgcgtctg	14	8	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr16:69373204G>C	uc002ewy.2	-	1	323	c.252C>G	c.(250-252)TTC>TTG	p.F84L	COG8_uc002ewz.3_Missense_Mutation_p.F84L|NIP7_uc002exa.2_5'Flank|NIP7_uc002exb.2_5'Flank	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	84					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						TGTAGTTAGCGAAGGCCAAGT	0.716													0	0	0	0.009096	0	4	30										C	69373204	G	C	69373204	3	2	51	1	0	0	0	0	1	0	0	0	3664	1049	37	1	1606	1	COG8	16	69373204	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		69373204	20981549	107	14307										
ANKRD11	29123	broad.mit.edu	37	chr16	89348346	89348346	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tttctttctctgcaccgtccTtgaatttctccttcagtttg	5	12	4	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr16:89348346T>C	uc002fmx.1	-	9	5065	c.4604A>G	c.(4603-4605)AAG>AGG	p.K1535R	ANKRD11_uc002fmy.1_Missense_Mutation_p.K1535R|ANKRD11_uc002fnc.1_Missense_Mutation_p.K1535R|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.K1492R	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1535	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGCACCGTCCTTGAATTTCTC	0.597													0	0	0	0.004672	0	3	84										C	89348346	T	C	89348346	3	2	51	1	0	0	0	0	1	0	0	0	639	1609	56	5	3407	5	ANKRD11	16	89348346	Missense_Mutation	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08	19975142	89348346	1006407	108	14308										
MINK1	50488	broad.mit.edu	37	chr17	4799524	4799524	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cccaccgccctctgctggtcGacctgacagtagaggagggg	14	14	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:4799524G>T	uc010vsl.1	+	29	3698	c.3502G>T	c.(3502-3504)GAC>TAC	p.D1168Y	MINK1_uc010vsk.1_Missense_Mutation_p.D1139Y|MINK1_uc010vsm.1_Missense_Mutation_p.D1148Y|MINK1_uc010vsn.1_Missense_Mutation_p.D1131Y|MINK1_uc010vso.1_Missense_Mutation_p.D1076Y|MINK1_uc010vsp.1_Missense_Mutation_p.D629Y	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	1168	Mediates interaction with RAP2A.|CNH.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						TCTGCTGGTCGACCTGACAGT	0.627											OREG0024107	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00116845	0.001168	0.00126139	6	53										T	4799524	G	T	4799524	3	4	51	1	0	0	0	0	1	0	0	0	9587	1058	37	3	3383	3	MINK1	17	4799524	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		4799524	76395686	109	14309										
CAMTA2	23125	broad.mit.edu	37	chr17	4883529	4883529	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gagctggtggggcagaaggcTcagtgcctacaaccactgcc	14	12	1	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:4883529T>C	uc002gah.1	-	9	1196	c.1088A>G	c.(1087-1089)GAG>GGG	p.E363G	CAMTA2_uc010cku.1_Missense_Mutation_p.E386G|CAMTA2_uc002gag.1_Missense_Mutation_p.E362G|CAMTA2_uc002gai.1_Missense_Mutation_p.E365G|CAMTA2_uc010ckv.1_Missense_Mutation_p.E10G|CAMTA2_uc010vsu.1_Missense_Mutation_p.E176G	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	363					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGCAGAAGGCTCAGTGCCTAC	0.617													0	0	0	0.003954	0	24	24										C	4883529	T	C	4883529	3	2	51	1	0	0	0	0	1	0	0	0	2614	1551	54	5	2630	5	CAMTA2	17	4883529	Missense_Mutation	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08	84005	4883529	76311681	110	14310										
SSH2	85464	broad.mit.edu	37	chr17	27963225	27963225	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	actaaaaaagtcaatgcgatCtgtactgaaatctgagattt	7	6	3	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:27963225C>G	uc002heo.1	-	14	1942	c.1942G>C	c.(1942-1944)GAT>CAT	p.D648H	SSH2_uc010wbh.1_Missense_Mutation_p.D675H	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	648					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCAATGCGATCTGTACTGAAA	0.498													0	0	0	0.004672	0	3	124										G	27963225	C	G	27963225	3	3	51	1	0	0	0	0	1	0	0	0	15184	913	32	1	2337	1	SSH2	17	27963225	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	23079696	27963225	53231985	111	14311										
MLLT6	4302	broad.mit.edu	37	chr17	36874167	36874167	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttggaacccccatgggtgccGttaatcccctcctctcccaa	7	17	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:36874167G>A	uc002hqi.3	+	12	1916	c.1903G>A	c.(1903-1905)GTT>ATT	p.V635I	MLLT6_uc002hqj.2_Missense_Mutation_p.V70I|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	635					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					CATGGGTGCCGTTAATCCCCT	0.557			T	MLL	AL								0	0	0	0.001984	0	6	170										A	36874167	G	A	36874167	3	1	51	1	0	0	0	0	1	0	0	0	9630	1145	40	2	1949	2	MLLT6	17	36874167	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	8910942	36874167	44321043	112	14312										
BECN1	8678	broad.mit.edu	37	chr17	40971588	40971588	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ggctggggggatgaatctgcGagagacaccatcctggcgag	17	9	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:40971588G>A	uc002ibo.3	-	4	373	c.238C>T	c.(238-240)CGC>TGC	p.R80C	BECN1_uc010whb.1_5'UTR|BECN1_uc010whc.1_Missense_Mutation_p.R80C|BECN1_uc002ibn.2_Missense_Mutation_p.R80C	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	80					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		ATGAATCTGCGAGAGACACCA	0.483											OREG0024429	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	46										A	40971588	G	A	40971588	3	1	51	1	0	0	0	0	1	0	0	0	1396	1058	37	1	1150	1	BECN1	17	40971588	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	4097421	40971588	40223622	113	14313										
MYST2	11143	broad.mit.edu	37	chr17	47893222	47893222	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttttagaaaacctgacaagcGagtatgacttggatcttttc	8	7	1	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:47893222G>A	uc002ipm.2	+	8	1036	c.910G>A	c.(910-912)GAG>AAG	p.E304K	MYST2_uc002ipl.1_Missense_Mutation_p.E274K|MYST2_uc010wma.1_Missense_Mutation_p.E165K|MYST2_uc010wmb.1_Missense_Mutation_p.E194K|MYST2_uc010wmc.1_Missense_Mutation_p.E135K|MYST2_uc010wmd.1_Missense_Mutation_p.E148K|MYST2_uc010wme.1_Missense_Mutation_p.E118K|MYST2_uc010wmf.1_5'UTR|MYST2_uc010wmg.1_5'UTR	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	304					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CCTGACAAGCGAGTATGACTT	0.463													0	0	0	0.00499	0	14	95										A	47893222	G	A	47893222	3	1	51	1	0	0	0	0	1	0	0	0	10103	1059	37	1	940	1	MYST2	17	47893222	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	6921634	47893222	33301988	114	14314										
ANKFN1	162282	broad.mit.edu	37	chr17	54450013	54450013	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttctttccctttagttgtcaGcctggaaagccgagcaatgc	9	11	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:54450013G>T	uc002iun.1	+	6	652	c.617G>T	c.(616-618)AGC>ATC	p.S206I		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	206	Potential.									large_intestine(1)|ovary(1)	2						TTAGTTGTCAGCCTGGAAAGC	0.463													1	0	1.77063e-15	0.005443	2.10263e-15	27	103										T	54450013	G	T	54450013	3	4	51	1	0	0	0	0	1	0	0	0	625	971	34	4	639	4	ANKFN1	17	54450013	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	6556791	54450013	26745197	115	14315										
TRIM25	7706	broad.mit.edu	37	chr17	54991298	54991298	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gaccggctccttgaagggctCcaggcagatggagcacgaca	14	12	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr17:54991298C>T	uc002iut.2	-	1	112	c.52G>A	c.(52-54)GAG>AAG	p.E18K	TRIM25_uc010dcj.2_5'UTR	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	18	RING-type.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					TTGAAGGGCTCCAGGCAGATG	0.682													0	0	0	0.009096	0	4	13										T	54991298	C	T	54991298	3	4	51	1	0	0	0	0	1	0	0	0	16496	864	30	1	1876	1	TRIM25	17	54991298	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	541285	54991298	26203912	116	14316										
MOCOS	55034	broad.mit.edu	37	chr18	33795828	33795828	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	acctgtgtgtgatgtcgccaGaacccagccgactccttcag	10	14	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr18:33795828G>A	uc002kzq.3	+	8	1708	c.1685G>A	c.(1684-1686)AGA>AAA	p.R562K		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	562					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GATGTCGCCAGAACCCAGCCG	0.552													0	0	0	0.001168	0	5	78										A	33795828	G	A	33795828	3	1	51	1	0	0	0	0	1	0	0	0	9689	942	33	1	1715	1	MOCOS	18	33795828	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		33795828	44281420	117	14317										
TCEB3C	162699	broad.mit.edu	37	chr18	44555115	44555115	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atcgggcgtccacccttccaGaacgggttcaagaaccgagt	11	13	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr18:44555115G>A	uc010xdb.1	-	1	1335	c.1099C>T	c.(1099-1101)CTG>TTG	p.L367L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	367	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						CACCCTTCCAGAACGGGTTCA	0.607													0	0	0	0.006122	0	12	788										A	44555115	G	A	44555115	2	1	51	1	0	0	0	0	0	0	0	1	15680	933	33	1		1	TCEB3C	18	44555115	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	10759287	44555115	33522133	118	14318										
C18orf54	162681	broad.mit.edu	37	chr18	51900620	51900620	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tctctaaattacagttgaagGaaagtatgattcctattact	6	6	1	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr18:51900620G>A	uc002lfn.3	+	7	1128	c.1012G>A	c.(1012-1014)GAA>AAA	p.E338K	C18orf54_uc002lfo.3_Missense_Mutation_p.E499K	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	338						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		ACAGTTGAAGGAAAGTATGAT	0.244													0	0	0	0.009096	0	3	43										A	51900620	G	A	51900620	3	1	51	1	0	0	0	0	1	0	0	0	1904	1175	41	1	1034	1	C18orf54	18	51900620	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	7345505	51900620	26176628	119	14319										
CDH20	28316	broad.mit.edu	37	chr18	59166706	59166706	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gccactgtgccagaaatgtcCcctgtgggtaaggtggtgac	14	10	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr18:59166706C>T	uc010dps.1	+	2	546	c.534C>T	c.(532-534)TCC>TCT	p.S178S	CDH20_uc002lif.2_Silent_p.S172S	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	178	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CAGAAATGTCCCCTGTGGGTA	0.378													0	0	0	0.001855	0	12	39										T	59166706	C	T	59166706	2	4	51	1	0	0	0	0	0	0	0	1	3106	610	22	2		2	CDH20	18	59166706	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	7266086	59166706	18910542	120	14320										
MUC16	94025	broad.mit.edu	37	chr19	9090712	9090712	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ccatggtctcagcgaaggcaTggaaggtaaggatagtctct	13	8	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:9090712T>C	uc002mkp.2	-	1	1307	c.1103A>G	c.(1102-1104)CAT>CGT	p.H368R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	368	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCGAAGGCATGGAAGGTAAG	0.502													0	0	0	0.010729	0	11	34										C	9090712	T	C	9090712	3	2	51	1	0	0	0	0	1	0	0	0	9973	1464	51	5	42756	5	MUC16	19	9090712	Missense_Mutation	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08		9090712	50038271	121	14321										
SMARCA4	6597	broad.mit.edu	37	chr19	11094864	11094864	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cacccctgggcggaactcctCggccaggtccttccccgggc	12	19	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:11094864C>T	uc002mqf.3	+	2	321	c.37C>T	c.(37-39)CGG>TGG	p.R13W	SMARCA4_uc010dxp.2_Missense_Mutation_p.R13W|SMARCA4_uc010dxo.2_Missense_Mutation_p.R13W|SMARCA4_uc002mqg.1_Missense_Mutation_p.R13W|SMARCA4_uc010dxq.2_Missense_Mutation_p.R13W|SMARCA4_uc010dxr.2_Missense_Mutation_p.R13W|SMARCA4_uc002mqj.3_Missense_Mutation_p.R13W|SMARCA4_uc010dxs.2_Missense_Mutation_p.R13W|SMARCA4_uc002mqe.2_Missense_Mutation_p.R13W	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	13	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CGGAACTCCTCGGCCAGGTCC	0.687			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.00245	0	13	56										T	11094864	C	T	11094864	3	4	51	1	0	0	0	0	1	0	0	0	14770	875	31	1	39	1	SMARCA4	19	11094864	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	2004152	11094864	48034119	122	14322										
PLVAP	83483	broad.mit.edu	37	chr19	17476167	17476167	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctgagctgctccgcctccctCttcttctcttccagctcctt	5	19	3	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:17476167C>G	uc002ngk.1	-	3	1157	c.1107G>C	c.(1105-1107)AAG>AAC	p.K369N		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	369	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CCGCCTCCCTCTTCTTCTCTT	0.617													0	0	0	0.004672	0	3	101										G	17476167	C	G	17476167	3	3	51	1	0	0	0	0	1	0	0	0	12116	912	32	1	237	1	PLVAP	19	17476167	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	6381303	17476167	41652816	123	14323										
GDF15	9518	broad.mit.edu	37	chr19	18499744	18499744	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	caaagactgccactgcatatGagcagtcctggtccttccac	8	14	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:18499744G>C	uc002niv.2	+	2	958	c.926G>C	c.(925-927)TGA>TCA	p.*309S		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	309					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						CACTGCATATGAGCAGTCCTG	0.572											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	10	78										C	18499744	G	C	18499744	4	2	51	1	0	0	0	0	0	0	0	0	6313	1285	45	1	932	1	GDF15	19	18499744	Nonstop_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	1023577	18499744	40629239	124	14324										
GATAD2A	54815	broad.mit.edu	37	chr19	19613328	19613328	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aactggaagaagacgcccctCagcacaggtgggtgacctcc	12	13	1	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:19613328C>A	uc010xqt.1	+	11	2076	c.1764C>A	c.(1762-1764)CTC>CTA	p.L588L	GATAD2A_uc010xqu.1_Silent_p.L217L|GATAD2A_uc010xqv.1_Silent_p.L608L|GATAD2A_uc010xqw.1_Silent_p.L391L	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	588					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGACGCCCCTCAGCACAGGTG	0.637													1	0	3.45872e-05	0.004007	3.84302e-05	16	86										A	19613328	C	A	19613328	2	1	51	1	0	0	0	0	0	0	0	1	6260	813	29	3		3	GATAD2A	19	19613328	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	1113584	19613328	39515655	125	14325										
ZNF99	7652	broad.mit.edu	37	chr19	22939368	22939368	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctctccagtatgaattgattTatgtttagtaaggtgtgagg	11	4	1	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:22939368T>C	uc010xrh.1	-	7	2803	c.2803A>G	c.(2803-2805)AAA>GAA	p.K935E		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGAATTGATTTATGTTTAGTA	0.373													0	0	0	0.004007	0	15	38										C	22939368	T	C	22939368	3	2	51	1	0	0	0	0	1	0	0	0	18201	1763	61	5	313	5	ZNF99	19	22939368	Missense_Mutation	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08	3326040	22939368	36189615	126	14326										
SCGBL	284402	broad.mit.edu	37	chr19	35085106	35085106	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aactgaatgagcaaatctttCtgtcacggagacattggcaa	9	8	3	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:35085106C>T	uc002nvn.2	-	2	242	c.220G>A	c.(220-222)GAA>AAA	p.E74K		NM_001025591	NP_001020762	Q4G0G5	SCGBL_HUMAN	secretoglobin-like precursor	74						extracellular region	binding				0						GCAAATCTTTCTGTCACGGAG	0.542													0	0	0	0.008871	0	17	175										T	35085106	C	T	35085106	3	4	51	1	0	0	0	0	1	0	0	0	13902	922	32	1	78	1	SCGBL	19	35085106	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	12145738	35085106	24043877	127	14327										
RSPH6A	81492	broad.mit.edu	37	chr19	46307611	46307611	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	cgggttctcctcgtaggagtCgcgcccagcaccaccttcct	10	17	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:46307611C>T	uc002pdm.2	-	3	1695	c.1552G>A	c.(1552-1554)GAC>AAC	p.D518N	RSPH6A_uc002pdl.2_Missense_Mutation_p.D254N	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	518	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						TCGTAGGAGTCGCGCCCAGCA	0.647													0	0	0	0.013537	0	12	88										T	46307611	C	T	46307611	3	4	51	1	0	0	0	0	1	0	0	0	13707	884	31	1	617	1	RSPH6A	19	46307611	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	11222505	46307611	12821372	128	14328										
SPHK2	56848	broad.mit.edu	37	chr19	49132875	49132875	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gtccgcagctgggctacgccGcggcccgtgccttccgccta	13	18	0	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:49132875G>A	uc002pjr.2	+	7	2176	c.1810G>A	c.(1810-1812)GCG>ACG	p.A604T	SPHK2_uc010xzt.1_Missense_Mutation_p.A545T|SPHK2_uc002pjs.2_Missense_Mutation_p.A604T|SPHK2_uc002pjt.2_Missense_Mutation_p.A398T|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Missense_Mutation_p.A568T|SPHK2_uc002pjw.2_Missense_Mutation_p.A666T	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	604					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GGGCTACGCCGCGGCCCGTGC	0.687													0	0	0	0.001168	0	4	10										A	49132875	G	A	49132875	3	1	51	1	0	0	0	0	1	0	0	0	15046	1087	38	2	1832	2	SPHK2	19	49132875	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	2825264	49132875	9996108	129	14329										
KLK10	5655	broad.mit.edu	37	chr19	51522384	51522384	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	aggtggaggtgcggagctctCatggccaggatctgctgggg	19	8	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:51522384C>T	uc002puy.2	-	2	84	c.3G>A	c.(1-3)ATG>ATA	p.M1I	KLK10_uc002puz.2_Missense_Mutation_p.M1I|KLK10_uc002pva.2_Missense_Mutation_p.M1I	NM_145888	NP_665895	O43240	KLK10_HUMAN	kallikrein-related peptidase 10 preproprotein	1					cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			lung(2)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		GCGGAGCTCTCATGGCCAGGA	0.687													0	0	0	0.009096	0	4	16										T	51522384	C	T	51522384	3	4	51	1	0	0	0	0	1	0	0	0	8398	826	29	1	847	1	KLK10	19	51522384	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	2389509	51522384	7606599	130	14330										
NLRP8	126205	broad.mit.edu	37	chr19	56466505	56466505	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ttccggggtttaatacgatgGaaaaaatcaagtatttccag	9	6	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr19:56466505G>T	uc002qmh.2	+	3	1152	c.1081G>T	c.(1081-1083)GAA>TAA	p.E361*	NLRP8_uc010etg.2_Nonsense_Mutation_p.E361*	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	361	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TAATACGATGGAAAAAATCAA	0.463													1	0	5.35356e-11	0.00278	6.27886e-11	25	56										T	56466505	G	T	56466505	4	4	51	1	0	0	0	0	0	1	0	0	10483	1175	41	3	1091	3	NLRP8	19	56466505	Nonsense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	4944121	56466505	2662478	131	14331										
C20orf141	128653	broad.mit.edu	37	chr20	2795885	2795885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gtgaggatccgatcccagttCctccaaggggcctgggtgct	14	12	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr20:2795885C>T	uc010gat.2	+	2	138	c.55C>T	c.(55-57)CCT>TCT	p.P19S	C20orf141_uc002wgv.1_Missense_Mutation_p.P19S|C20orf141_uc002wgw.2_Missense_Mutation_p.P19S|uc002wgx.1_5'Flank|uc002wgy.1_5'Flank	NM_080739	NP_542777	Q9NUB4	CT141_HUMAN	hypothetical protein LOC128653	19						integral to membrane					0						GATCCCAGTTCCTCCAAGGGG	0.617													0	0	0	0.004482	0	9	156										T	2795885	C	T	2795885	3	4	51	1	0	0	0	0	1	0	0	0	2089	855	30	1	57	1	C20orf141	20	2795885	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		2795885	60229635	132	14332										
ZHX3	23051	broad.mit.edu	37	chr20	39833262	39833262	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tttattaaagtctgtgtgctCtgagttcatatgtcccacaa	7	8	3	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr20:39833262C>T	uc002xjs.1	-	3	673	c.295G>A	c.(295-297)GAG>AAG	p.E99K	ZHX3_uc002xjq.1_Missense_Mutation_p.E99K|ZHX3_uc002xjr.1_Missense_Mutation_p.E99K|ZHX3_uc002xjt.1_Missense_Mutation_p.E99K|ZHX3_uc002xju.1_Missense_Mutation_p.E99K|ZHX3_uc002xjv.1_Missense_Mutation_p.E99K|ZHX3_uc002xjw.1_Missense_Mutation_p.E99K|ZHX3_uc010ggg.1_Missense_Mutation_p.E99K	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	99	Required for nuclear localization.|C2H2-type 1.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				TCTGTGTGCTCTGAGTTCATA	0.443													0	0	0	0.001168	0	5	136										T	39833262	C	T	39833262	3	4	51	1	0	0	0	0	1	0	0	0	17674	922	32	1	2583	1	ZHX3	20	39833262	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	37037377	39833262	23192258	133	14333										
COL6A1	1291	broad.mit.edu	37	chr21	47423837	47423837	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gagtacgacgtggcctacggCgagagccacctgttccgtgt	14	12	0	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chr21:47423837C>T	uc002zhu.1	+	35	3099	c.2997C>T	c.(2995-2997)GGC>GGT	p.G999G	COL6A1_uc010gqd.1_Silent_p.G330G|COL6A1_uc002zhv.1_Silent_p.G330G|COL6A1_uc002zhw.1_Silent_p.G93G	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	999	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TGGCCTACGGCGAGAGCCACC	0.667													0	0	0	0.010729	0	11	102										T	47423837	C	T	47423837	2	4	51	1	0	0	0	0	0	0	0	1	3699	755	27	2		2	COL6A1	21	47423837	Silent	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08		47423837	706058	134	14334										
ASMTL	8623	broad.mit.edu	37	chrX	1553955	1553955	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	atcgcgacacctgtgaacacGctgtgttctctcccactcaa	7	15	2	1			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:1553955G>A	uc004cpx.1	-	5	471	c.360C>T	c.(358-360)AGC>AGT	p.S120S	ASMTL_uc011mhe.1_Silent_p.S44S|ASMTL_uc004cpy.1_Silent_p.S104S|ASMTL_uc011mhf.1_Silent_p.S62S	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	120	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTGTGAACACGCTGTGTTCTC	0.587													0	0	0	0.00308	0	6	96										A	1553955	G	A	1553955	2	1	51	1	0	0	0	0	0	0	0	1	1046	1078	38	2		2	ASMTL	23	1553955	Silent	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08		1553955	153716605	135	14335										
ARSD	414	broad.mit.edu	37	chrX	2828744	2828744	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctaactggctgtgtccatctCttgcctctaaatgtcctcca	6	14	2	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:2828744C>G	uc004cqy.2	-	7	1167	c.1091G>C	c.(1090-1092)AGA>ACA	p.R364T	ARSD_uc004cqz.1_Intron	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	364						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTGTCCATCTCTTGCCTCTAA	0.443													0	0	0	0.009096	0	4	251										G	2828744	C	G	2828744	3	3	51	1	0	0	0	0	1	0	0	0	989	913	32	1	706	1	ARSD	23	2828744	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	1274789	2828744	152441816	136	14336										
DMD	1756	broad.mit.edu	37	chrX	32235111	32235111	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	agaaactgttcagcttctgtTagccactgattaaatatctt	6	8	3	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:32235111T>C	uc004dda.1	-	44	6604	c.6360A>G	c.(6358-6360)CTA>CTG	p.L2120L	DMD_uc004dcw.2_Silent_p.L776L|DMD_uc004dcx.2_Silent_p.L779L|DMD_uc004dcz.2_Silent_p.L1997L|DMD_uc004dcy.1_Silent_p.L2116L|DMD_uc004ddb.1_Silent_p.L2112L|DMD_uc010ngo.1_Silent_p.L29L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2120	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAGCTTCTGTTAGCCACTGAT	0.343													0	0	0	0.013537	0	13	19										C	32235111	T	C	32235111	2	2	51	1	0	0	0	0	0	0	0	1	4580	1741	61	5		5	DMD	23	32235111	Silent	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08	29406367	32235111	123035449	137	14337										
RBM10	8241	broad.mit.edu	37	chrX	47030582	47030582	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	gaggaggaggaggaggaggaGgatgaggaggaggaggagaa	25	0	0	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:47030582G>T	uc004dhf.2	+	4	736	c.357G>T	c.(355-357)GAG>GAT	p.E119D	RBM10_uc004dhe.1_Missense_Mutation_p.E109D|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_Missense_Mutation_p.E119D|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_Missense_Mutation_p.E184D	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	119	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						aggaggaggaggatgaggagg	0.522													1	0	0.000602214	0.000602	0.000661392	5	38										T	47030582	G	T	47030582	3	4	51	1	0	0	0	0	1	0	0	0	13111	991	35	4	367	4	RBM10	23	47030582	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	14795471	47030582	108239978	138	14338										
DGKK	139189	broad.mit.edu	37	chrX	50213512	50213512	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	agcaagctctggacagggctCtggtatgggttctggcgaag	16	8	3	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:50213512C>G	uc010njr.1	-	1	226	c.166G>C	c.(166-168)GAG>CAG	p.E56Q		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	56	3.|33 X 4 AA approximate tandem repeats of E-P-A-P.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GGACAGGGCTCTGGTATGGGT	0.323													0	0	0	0.00499	0	18	101										G	50213512	C	G	50213512	3	3	51	1	0	0	0	0	1	0	0	0	4472	922	32	1	3760	1	DGKK	23	50213512	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	3182930	50213512	105057048	139	14339										
SMC1A	8243	broad.mit.edu	37	chrX	53436075	53436075	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tgctctcctggcggtcgatgCgggcatcccctagctgctcc	12	16	1	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:53436075C>T	uc004dsg.2	-	9	1532	c.1463G>A	c.(1462-1464)CGC>CAC	p.R488H	SMC1A_uc011moe.1_Missense_Mutation_p.R466H|SMC1A_uc011mof.1_Missense_Mutation_p.R254H	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	488	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						GCGGTCGATGCGGGCATCCCC	0.567													0	0	0	0.001168	0	4	93										T	53436075	C	T	53436075	3	4	51	1	0	0	0	0	1	0	0	0	14781	768	27	2	2306	2	SMC1A	23	53436075	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	3222563	53436075	101834485	140	14340										
UBQLN2	29978	broad.mit.edu	37	chrX	56590917	56590917	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	tcccgatctgatgaggcagcTcattatggctaatccacaga	9	11	2	3			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:56590917T>C	uc004dus.2	+	1	846	c.611T>C	c.(610-612)CTG>CCG	p.L204P	UBQLN2_uc011moq.1_Missense_Mutation_p.L204P	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	204						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						ATGAGGCAGCTCATTATGGCT	0.453													0	0	0	0.00623	0	40	43										C	56590917	T	C	56590917	3	2	51	1	0	0	0	0	1	0	0	0	16894	1551	54	5	613	5	UBQLN2	23	56590917	Missense_Mutation	SNP	T	TCGA-DK-A2HX-01A-12D-A18F-08	3154842	56590917	98679643	141	14341										
LAS1L	81887	broad.mit.edu	37	chrX	64749124	64749124	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	ctcttcgtatgataccagcaGttctcgggctctttctgaaa	8	11	4	2			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:64749124G>T	uc004dwa.1	-	6	886	c.814C>A	c.(814-816)CTG>ATG	p.L272M	LAS1L_uc004dwc.1_Missense_Mutation_p.L272M|LAS1L_uc004dwd.1_Missense_Mutation_p.L230M	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	272						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						GATACCAGCAGTTCTCGGGCT	0.463											OREG0019826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	4.35082e-09	0.010504	5.04058e-09	20	33										T	64749124	G	T	64749124	3	4	51	1	0	0	0	0	1	0	0	0	8636	1020	36	4	1426	4	LAS1L	23	64749124	Missense_Mutation	SNP	G	TCGA-DK-A2HX-01A-12D-A18F-08	8158207	64749124	90521436	142	14342										
USP26	83844	broad.mit.edu	37	chrX	132160985	132160985	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.377622377622378	54	3.23404549382555e-17	3.4990990990991	6.59320987654321	2.64555129842486	0.100502011125719	0.217754357439058	39	actggtgtcaggatcatcagCaaaaacctgtttaggaaaat	9	7	3	0			TCGA-DK-A2HX-01A-12D-A18F-08	TCGA-DK-A2HX-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8f0d416-2102-43ea-9cf1-465c37f9642a	50c589ea-8019-4a0d-92c8-afe1a1e737de	g.chrX:132160985C>T	uc010nrm.1	-	6	1734	c.1264G>A	c.(1264-1266)GCT>ACT	p.A422T	USP26_uc011mvf.1_Missense_Mutation_p.A422T	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	422					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					GGATCATCAGCAAAAACCTGT	0.373													0	0	0	0.00499	0	18	70										T	132160985	C	T	132160985	3	4	51	1	0	0	0	0	1	0	0	0	17054	710	25	2	1480	2	USP26	23	132160985	Missense_Mutation	SNP	C	TCGA-DK-A2HX-01A-12D-A18F-08	67411861	132160985	23109575	143	14343										
DNAJC11	55735	broad.mit.edu	37	chr1	6704689	6704689	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaaacgctgtgcctggagatCttcctctcagctccgtactc	8	14	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:6704689C>T	uc001aof.2	-	10	1132	c.1026G>A	c.(1024-1026)AAG>AAA	p.K342K	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.K342K|DNAJC11_uc010nzu.1_Silent_p.K252K	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	342					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		GCCTGGAGATCTTCCTCTCAG	0.552													0	0	0	0.000491102	0	30	52										T	6704689	C	T	6704689	2	4	52	1	0	0	0	0	0	0	0	1	4630	912	32	1		1	DNAJC11	1	6704689	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		6704689	242545932	1	14344										
MTHFR	4524	broad.mit.edu	37	chr1	11854538	11854538	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccttgggggacttgctcttCaggtagaagaggtagtagtc	14	7	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:11854538C>G	uc001atc.1	-	8	1408	c.1224G>C	c.(1222-1224)CTG>CTC	p.L408L	MTHFR_uc001atb.1_Silent_p.L431L	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	408					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	ACTTGCTCTTCAGGTAGAAGA	0.562													0	0	0	0.000229342	0	18	106										G	11854538	C	G	11854538	2	3	52	1	0	0	0	0	0	0	0	1	9931	813	29	1		1	MTHFR	1	11854538	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	5149849	11854538	237396083	2	14345										
MACF1	23499	broad.mit.edu	37	chr1	39776610	39776610	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcaaacgaattcagtctctaGccagctctaggactgacaga	8	11	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:39776610G>A	uc010ois.1	+	27	3428	c.3223G>A	c.(3223-3225)GCC>ACC	p.A1075T	MACF1_uc001cda.1_Missense_Mutation_p.A983T|MACF1_uc001cdc.1_Missense_Mutation_p.A162T|MACF1_uc009vvq.1_Missense_Mutation_p.A132T|MACF1_uc001cdb.1_Missense_Mutation_p.A162T	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1075					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCAGTCTCTAGCCAGCTCTAG	0.502													0	0	0	0.000147903	0	42	63										A	39776610	G	A	39776610	3	1	52	1	0	0	0	0	1	0	0	0	9144	971	34	2	3321	2	MACF1	1	39776610	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	27922072	39776610	209474011	3	14346										
LEPRE1	64175	broad.mit.edu	37	chr1	43228147	43228147	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gctttctccaacttgttgatCtaagaatgaagcatgagaag	9	7	2	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:43228147C>G	uc001chv.2	-	2	579	c.466_splice	c.e2-1	p.I156_splice	LEPRE1_uc001chw.2_Splice_Site_p.I156_splice|LEPRE1_uc001chx.3_Splice_Site_p.I156_splice|LEPRE1_uc001chy.3_Intron	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1						negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACTTGTTGATCTAAGAATGAA	0.463													0	0	0	0.000147903	0	48	95										G	43228147	C	G	43228147	5	3	52	1	0	0	0	0	0	0	1	0	8729	927	32	1	1820	1	LEPRE1	1	43228147	Splice_Site	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3451537	43228147	206022474	4	14347										
KIAA0467	23334	broad.mit.edu	37	chr1	43902989	43902989	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggggcccagcatgggggtctCtcggggtatgtgattggcat	18	8	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:43902989C>G	uc001cjk.1	+	28	3947	c.3485C>G	c.(3484-3486)TCT>TGT	p.S1162C		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2061						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ATGGGGGTCTCTCGGGGTATG	0.552													0	0	0	0.000295444	0	20	90										G	43902989	C	G	43902989	3	3	52	1	0	0	0	0	1	0	0	0	8178	913	32	1	3587	1	KIAA0467	1	43902989	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	674842	43902989	205347632	5	14348										
STIL	6491	broad.mit.edu	37	chr1	47728683	47728683	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcagaattgttactggcaccCcctgttggtccagtctgtaa	9	11	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:47728683C>A	uc001crc.1	-	15	2873	c.2718G>T	c.(2716-2718)GGG>GGT	p.G906G	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.G860G|STIL_uc010omo.1_Silent_p.G889G|STIL_uc001crd.1_Silent_p.G907G|STIL_uc001cre.1_Silent_p.G906G|STIL_uc001crf.1_Silent_p.G519G|STIL_uc001crg.1_Silent_p.G842G	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	906					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TACTGGCACCCCCTGTTGGTC	0.433													1	0	0.000274275	0.000274275	0.00417306	8	144										A	47728683	C	A	47728683	2	1	52	1	0	0	0	0	0	0	0	1	15281	610	22	4		4	STIL	1	47728683	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3825694	47728683	201521938	6	14349										
BTF3L4	91408	broad.mit.edu	37	chr1	52530608	52530608	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ataatatagctggtattgaaGaggtatgatcactttgcaag	10	4	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:52530608G>C	uc001ctk.2	+	3	374	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	BTF3L4_uc001ctl.2_5'UTR|BTF3L4_uc010onh.1_RNA|BTF3L4_uc001ctm.2_Missense_Mutation_p.E56Q	NM_152265	NP_689478	Q96K17	BT3L4_HUMAN	basic transcription factor 3-like 4 isoform 1	56	NAC-A/B.									large_intestine(1)	1						TGGTATTGAAGAGGTATGATC	0.358													0	0	0	0.000175454	0	22	52										C	52530608	G	C	52530608	3	2	52	1	0	0	0	0	1	0	0	0	1552	943	33	1	172	1	BTF3L4	1	52530608	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	4801925	52530608	196720013	7	14350										
GPR88	54112	broad.mit.edu	37	chr1	101005559	101005559	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaacgaggagttccgccgctCcgtgcgctcagtcctgccgg	14	15	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:101005559C>A	uc001dth.2	+	2	1441	c.1037C>A	c.(1036-1038)TCC>TAC	p.S346Y		NM_022049	NP_071332	Q9GZN0	GPR88_HUMAN	G-protein coupled receptor 88	346	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		TTCCGCCGCTCCGTGCGCTCA	0.741													1	0	0.00024832	0.00024832	0.00378859	3	0										A	101005559	C	A	101005559	3	1	52	1	0	0	0	0	1	0	0	0	6717	855	30	3	1039	3	GPR88	1	101005559	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	48474951	101005559	148245062	8	14351										
CELSR2	1952	broad.mit.edu	37	chr1	109793966	109793966	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggccccagtactccgagtcaCagcctcggatcgagacaagg	12	14	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:109793966C>T	uc001dxa.3	+	1	1326	c.1265C>T	c.(1264-1266)ACA>ATA	p.T422I		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	422	Cadherin 3.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCCGAGTCACAGCCTCGGAT	0.557													0	0	0	0.000175454	0	19	60										T	109793966	C	T	109793966	3	4	52	1	0	0	0	0	1	0	0	0	3222	478	17	2	1267	2	CELSR2	1	109793966	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	8788407	109793966	139456655	9	14352										
CHIA	27159	broad.mit.edu	37	chr1	111853046	111853046	+	Translation_Start_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctttgtgataaccacagaatCagaacatataaaaagctctg	6	8	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:111853046C>G	uc001eas.2	+	2	60	c.-43C>G	c.(-45--41)ATCAG>ATGAG		CHIA_uc001ear.2_Intron|CHIA_uc001eaq.2_Translation_Start_Site|CHIA_uc009wgc.2_Intron|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_Translation_Start_Site|CHIA_uc001eau.2_Translation_Start_Site|CHIA_uc009wgd.2_Translation_Start_Site	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c						apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		ACCACAGAATCAGAACATATA	0.408													0	0	0	0.000219431	0	15	33										G	111853046	C	G	111853046	1	3	52	1	0	0	0	0	0	0	0	0	3342	841	29	1		1	CHIA	1	111853046	Translation_Start_Site	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2059080	111853046	137397575	10	14353										
NBPF14	25832	broad.mit.edu	37	chr1	148004641	148004641	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccacgtaaagggcgaagctGatatgctcttcctcaaatga	9	10	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:148004641G>C	uc001eqq.2	-	22	2690	c.2673C>G	c.(2671-2673)ATC>ATG	p.I891M	LOC200030_uc010ozz.1_Intron|LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Missense_Mutation_p.I239M|NBPF14_uc010pac.1_Missense_Mutation_p.I464M	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	891	NBPF 10.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					GGGCGAAGCTGATATGCTCTT	0.438													0	0	0	0.000147903	0	158	192										C	148004641	G	C	148004641	3	2	52	1	0	0	0	0	1	0	0	0	10194	1280	45	1	96	1	NBPF14	1	148004641	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	36151595	148004641	101245980	11	14354										
MTMR11	10903	broad.mit.edu	37	chr1	149906158	149906158	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcctgcttcttccgctcagtCtcccagtcttccgctgtctc	7	18	5	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:149906158C>T	uc001etl.3	-	7	860	c.609G>A	c.(607-609)GAG>GAA	p.E203E	MTMR11_uc001etm.1_Silent_p.E131E|MTMR11_uc010pbm.1_Silent_p.E175E|MTMR11_uc010pbn.1_Silent_p.E45E	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	203	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TCCGCTCAGTCTCCCAGTCTT	0.572													0	0	0	0.000409698	0	32	49										T	149906158	C	T	149906158	2	4	52	1	0	0	0	0	0	0	0	1	9940	912	32	1		1	MTMR11	1	149906158	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1901517	149906158	99344463	12	14355										
SELENBP1	8991	broad.mit.edu	37	chr1	151341538	151341538	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccaccacatagatgcgagagGagatgagactgggcagcacc	13	11	0	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:151341538G>A	uc001exx.2	-	4	349	c.302C>T	c.(301-303)TCC>TTC	p.S101F	SELENBP1_uc010pcy.1_Missense_Mutation_p.S143F|SELENBP1_uc001exy.2_5'UTR|SELENBP1_uc001exz.2_5'UTR|SELENBP1_uc010pcz.1_Intron|SELENBP1_uc009wms.2_5'UTR|SELENBP1_uc009wmt.2_5'UTR|SELENBP1_uc001eya.2_Missense_Mutation_p.S37F|SELENBP1_uc009wmu.2_5'UTR	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	101					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GATGCGAGAGGAGATGAGACT	0.592													0	0	0	0.000319135	0	40	52										A	151341538	G	A	151341538	3	1	52	1	0	0	0	0	1	0	0	0	14014	1174	41	1	1152	1	SELENBP1	1	151341538	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1435380	151341538	97909083	13	14356										
SELENBP1	8991	broad.mit.edu	37	chr1	151341620	151341620	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcaggtgttccatcctgagtGatgcagctcgtccttcaggt	12	11	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:151341620G>C	uc001exx.2	-	4	267	c.220C>G	c.(220-222)CAC>GAC	p.H74D	SELENBP1_uc010pcy.1_Missense_Mutation_p.H116D|SELENBP1_uc001exy.2_Translation_Start_Site|SELENBP1_uc001exz.2_Translation_Start_Site|SELENBP1_uc010pcz.1_Intron|SELENBP1_uc009wms.2_Translation_Start_Site|SELENBP1_uc009wmt.2_Translation_Start_Site|SELENBP1_uc001eya.2_Missense_Mutation_p.H10D|SELENBP1_uc009wmu.2_Translation_Start_Site	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	74					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CATCCTGAGTGATGCAGCTCG	0.552													0	0	0	0.00058488	0	32	74										C	151341620	G	C	151341620	3	2	52	1	0	0	0	0	1	0	0	0	14014	1290	45	1	1234	1	SELENBP1	1	151341620	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	82	151341620	97909001	14	14357										
SPRR1A	6698	broad.mit.edu	37	chr1	152957821	152957821	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	catgcatccccaaaaccaagGagccctgccaccccaaggtg	8	17	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:152957821G>A	uc009wnu.1	+	2	193	c.115G>A	c.(115-117)GAG>AAG	p.E39K	SPRR1A_uc001faw.2_Missense_Mutation_p.E39K	NM_005987	NP_005978	P35321	SPR1A_HUMAN	small proline-rich protein 1A	39	2.|6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity				0	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAAACCAAGGAGCCCTGCCA	0.652													0	0	0	0.000227799	0	30	125										A	152957821	G	A	152957821	3	1	52	1	0	0	0	0	1	0	0	0	15094	1175	41	1	117	1	SPRR1A	1	152957821	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1616201	152957821	96292800	15	14358										
ARHGEF2	9181	broad.mit.edu	37	chr1	155931990	155931990	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcctgtaccccgtgccgcttGagcacggcggggcgggtcac	15	15	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:155931990G>A	uc001fmt.2	-	10	1243	c.1125C>T	c.(1123-1125)CTC>CTT	p.L375L	ARHGEF2_uc001fmr.2_Silent_p.L347L|ARHGEF2_uc001fms.2_Silent_p.L374L|ARHGEF2_uc001fmu.2_Silent_p.L419L|ARHGEF2_uc010pgt.1_Silent_p.L348L|ARHGEF2_uc010pgu.1_Silent_p.L420L	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	375	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CGTGCCGCTTGAGCACGGCGG	0.637													0	0	0	0.000184323	0	25	44										A	155931990	G	A	155931990	2	1	52	1	0	0	0	0	0	0	0	1	903	1277	45	1		1	ARHGEF2	1	155931990	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2974169	155931990	93318631	16	14359										
GPATCH4	54865	broad.mit.edu	37	chr1	156565923	156565923	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agcagcatctcatcagtcagActgttaggggagatcagcag	12	9	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:156565923A>G	uc001fpm.2	-	7	480	c.441T>C	c.(439-441)ATT>ATC	p.I147I	APOA1BP_uc010php.1_Intron|GPATCH4_uc001fpl.2_Silent_p.I142I	NM_015590	NP_056405	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4 isoform 1	142						intracellular	nucleic acid binding			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CATCAGTCAGACTGTTAGGGG	0.428													0	0	0	6.4e-05	0	3	113										G	156565923	A	G	156565923	2	3	52	1	0	0	0	0	0	0	0	1	6593	289	10	5		5	GPATCH4	1	156565923	Silent	SNP	A	TCGA-DK-A2I1-01A-11D-A17V-08	633933	156565923	92684698	17	14360										
COPA	1314	broad.mit.edu	37	chr1	160267491	160267492	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gccacttctcccagcttttcCcagcagttcttgtcatccag							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:160267491_160267492CC>AA	uc009wti.2	-	20	2415_2416	c.2021_2022GG>TT	c.(2020-2022)TGG>TTT	p.W674F	COPA_uc001fvv.3_Missense_Mutation_p.W683F	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	674					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCAGCTTTTCCCAGCAGTTCTT	0.475													0	0	0	6.4e-05	0	11	278										AA	160267492	CC	AA	160267491	3	1	52	1	0	0	0	0	1	0	0	0	3727	624	22	4	1708	4	COPA	1	160267491	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	3701568	160267491	88983130	18	14361										
FCGR3B	2215	broad.mit.edu	37	chr1	161599754	161599754	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtaggctccctggcacttcaGagtcacactgtccttctcaa	8	14	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:161599754G>C	uc009wul.2	-	3	407	c.133C>G	c.(133-135)CTG>GTG	p.L45V		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	45	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGGCACTTCAGAGTCACACTG	0.532													0	0	0	0.00058488	0	31	308										C	161599754	G	C	161599754	3	2	52	1	0	0	0	0	1	0	0	0	5785	933	33	1	580	1	FCGR3B	1	161599754	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1332263	161599754	87650867	19	14362										
PIK3C2B	5287	broad.mit.edu	37	chr1	204400888	204400889	+	Frame_Shift_Ins	INS	-	-	A													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tggatgtaggtggcctcgtgINSagtgttctctcgcatcacct							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:204400888_204400889insA	uc001haw.2	-	29	4667_4668	c.4188_4189insT	c.(4186-4191)ACTCACfs	p.T1396fs	PIK3C2B_uc010pqv.1_Frame_Shift_Ins_p.T1368fs	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1396_1397	PX.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GTGGCCTCGTGAGTGTTCTCTC	0.535											OREG0014134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						43	171	---	---								A	204400889	-	A	204400888	7	5	52	1	0	1	1	0	0	0	0	0	11910	1290	45	0	739	0	PIK3C2B	1	204400888	Frame_Shift_Ins	INS	-	TCGA-DK-A2I1-01A-11D-A17V-08	42801134	204400888	44849733	20	14363										
SRGAP2	23380	broad.mit.edu	37	chr1	206623769	206623769	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gactacctcggttgaagactCaacccaggatgtgaccgcag	11	12	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:206623769C>G	uc001hdy.2	+	16	2210	c.1877C>G	c.(1876-1878)TCA>TGA	p.S626*	SRGAP2_uc010prt.1_Nonsense_Mutation_p.S549*|SRGAP2_uc001hdx.2_Nonsense_Mutation_p.S626*|SRGAP2_uc010pru.1_Nonsense_Mutation_p.S549*|SRGAP2_uc010prv.1_Nonsense_Mutation_p.S550*	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	713					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					GTTGAAGACTCAACCCAGGAT	0.552													0	0	0	6.40141e-05	0	8	23										G	206623769	C	G	206623769	4	3	52	1	0	0	0	0	0	1	0	0	15145	838	29	1	1940	1	SRGAP2	1	206623769	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2222881	206623769	42626852	21	14364										
IARS2	55699	broad.mit.edu	37	chr1	220276871	220276871	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	catctgttgcttctactttgGaaacaacatttgagactatt	6	8	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:220276871G>A	uc001hmc.2	+	8	1137	c.1033G>A	c.(1033-1035)GAA>AAA	p.E345K		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	345					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TTCTACTTTGGAAACAACATT	0.358													0	0	0	0.000184323	0	28	63										A	220276871	G	A	220276871	3	1	52	1	0	0	0	0	1	0	0	0	7474	1175	41	1	1063	1	IARS2	1	220276871	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	13653102	220276871	28973750	22	14365										
LYST	1130	broad.mit.edu	37	chr1	235922510	235922510	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctcatccccaggactgtcatCttctgacctgggttctgctc	8	15	5	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:235922510C>T	uc001hxj.2	-	23	6818	c.6643G>A	c.(6643-6645)GAT>AAT	p.D2215N	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2215					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGACTGTCATCTTCTGACCTG	0.547									Chediak-Higashi_syndrome				0	0	0	0.000159656	0	35	74										T	235922510	C	T	235922510	3	4	52	1	0	0	0	0	1	0	0	0	9128	913	32	1	4886	1	LYST	1	235922510	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	15645639	235922510	13328111	23	14366										
KIF26B	55083	broad.mit.edu	37	chr1	245772624	245772624	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgcagaacctgggcatcattCcctgtgccatctcttggctc	9	14	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:245772624C>T	uc001ibf.1	+	8	2148	c.1708C>T	c.(1708-1710)CCC>TCC	p.P570S	KIF26B_uc010pyq.1_Missense_Mutation_p.P570S|KIF26B_uc001ibg.1_Missense_Mutation_p.P188S	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	570	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GGGCATCATTCCCTGTGCCAT	0.532													0	0	0	6.40141e-05	0	11	18										T	245772624	C	T	245772624	3	4	52	1	0	0	0	0	1	0	0	0	8295	855	30	1	1738	1	KIF26B	1	245772624	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	9850114	245772624	3477997	24	14367										
OR2G2	81470	broad.mit.edu	37	chr1	247751675	247751675	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tttacatatggggatggtgaGacataccaatgagagcaacc	11	7	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:247751675G>C	uc010pyy.1	+	1	14	c.14G>C	c.(13-15)AGA>ACA	p.R5T		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGGATGGTGAGACATACCAAT	0.413													0	0	0	0.000491102	0	24	98										C	247751675	G	C	247751675	3	2	52	1	0	0	0	0	1	0	0	0	10998	942	33	1	16	1	OR2G2	1	247751675	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1979051	247751675	1498946	25	14368			1	55		5	5	906	G		2.183013e-10
OR2G2	81470	broad.mit.edu	37	chr1	247751725	247751725	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcatccttttagggttttctGattatcctcagttacagaag	7	8	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:247751725G>C	uc010pyy.1	+	1	64	c.64G>C	c.(64-66)GAT>CAT	p.D22H		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGGGTTTTCTGATTATCCTCA	0.413													0	0	0	0.000147802	0	22	109										C	247751725	G	C	247751725	3	2	52	1	0	0	0	0	1	0	0	0	10998	1290	45	1	66	1	OR2G2	1	247751725	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	50	247751725	1498896	26	14369			1	55		5	5	906	G		2.183013e-10
OR2G2	81470	broad.mit.edu	37	chr1	247752001	247752001	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cccatgccctgggatccactGagtgcgtcctcccggctgtg	12	16	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:247752001G>A	uc010pyy.1	+	1	340	c.340G>A	c.(340-342)GAG>AAG	p.E114K		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGGATCCACTGAGTGCGTCCT	0.527													0	0	0	0.000509022	0	40	122										A	247752001	G	A	247752001	3	1	52	1	0	0	0	0	1	0	0	0	10998	1291	45	1	342	1	OR2G2	1	247752001	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	276	247752001	1498620	27	14370			1	55		5	5	906	G		2.183013e-10
OR2G2	81470	broad.mit.edu	37	chr1	247752462	247752462	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atgtatctgcagccagccaaGagtagatccagggaccaggg	13	10	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:247752462G>T	uc010pyy.1	+	1	801	c.801G>T	c.(799-801)AAG>AAT	p.K267N		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			agCCAGCCAAGAGTAGATCCA	0.383													1	0	1.62957e-23	0.000374591	2.69465e-22	41	145										T	247752462	G	T	247752462	3	4	52	1	0	0	0	0	1	0	0	0	10998	933	33	3	803	3	OR2G2	1	247752462	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	461	247752462	1498159	28	14371			1	55		5	5	906	G		2.183013e-10
OR2G2	81470	broad.mit.edu	37	chr1	247752580	247752580	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgaaaggggcattaaagaaaGttctagcaaaggctctggga	13	5	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr1:247752580G>T	uc010pyy.1	+	1	919	c.919G>T	c.(919-921)GTT>TTT	p.V307F		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATTAAAGAAAGTTCTAGCAAA	0.338													1	0	2.08457e-15	0.000339439	3.39619e-14	32	117										T	247752580	G	T	247752580	3	4	52	1	0	0	0	0	1	0	0	0	10998	1029	36	4	921	4	OR2G2	1	247752580	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	118	247752580	1498041	29	14372			1	55		5	5	906	G		2.183013e-10
PKDCC	91461	broad.mit.edu	37	chr2	42282449	42282449	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agctcgcctggggggtggacGagaccctggcccagctggag	18	12	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:42282449G>C	uc002rsg.2	+	5	1317	c.1138G>C	c.(1138-1140)GAG>CAG	p.E380Q		NM_138370	NP_612379	Q504Y2	PKDCC_HUMAN	protein kinase-like protein SgK493	380	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(1)	1						GGGGGTGGACGAGACCCTGGC	0.647													0	0	0	0.000442599	0	9	43										C	42282449	G	C	42282449	3	2	52	1	0	0	0	0	1	0	0	0	11969	1059	37	1	1156	1	PKDCC	2	42282449	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		42282449	200916924	30	14373										
INPP4A	3631	broad.mit.edu	37	chr2	99182196	99182196	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcaggccacttccagcgcctCcgcagacatgctgcccgtca	9	18	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:99182196C>G	uc002syy.2	+	21	2654	c.2261C>G	c.(2260-2262)TCC>TGC	p.S754C	INPP4A_uc010yvj.1_Missense_Mutation_p.S715C|INPP4A_uc010yvk.1_Missense_Mutation_p.S715C|INPP4A_uc002syx.2_Missense_Mutation_p.S749C|INPP4A_uc010fik.2_Missense_Mutation_p.S83C	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	754					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						TCCAGCGCCTCCGCAGACATG	0.517													0	0	0	0.000319135	0	35	57										G	99182196	C	G	99182196	3	3	52	1	0	0	0	0	1	0	0	0	7752	855	30	1	2335	1	INPP4A	2	99182196	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	56899747	99182196	144017177	31	14374										
RABL2A	11159	broad.mit.edu	37	chr2	114399705	114399705	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggtggcctctccccacagctGaggggctggggctaggggtg	19	11	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:114399705G>A	uc002tkn.3	+	9	900	c.686G>A	c.(685-687)TGA>TAA	p.*229*	RABL2A_uc010flb.2_Silent_p.*229*|RABL2A_uc002tkl.3_Silent_p.*148*|RABL2A_uc002tkm.3_Silent_p.*166*|RABL2A_uc002tks.3_Silent_p.*230*|RABL2A_uc002tkr.2_Silent_p.*230*|RABL2A_uc002tkp.3_Intron	NM_007082	NP_009013	Q9UBK7	RBL2A_HUMAN	RAB, member of RAS oncogene family-like 2A	229					small GTPase mediated signal transduction		GTP binding|GTPase activity			skin(1)	1						CCCCACAGCTGAGGGGCTGGG	0.572													0	0	0	0.00010058	0	12	41										A	114399705	G	A	114399705	2	1	52	1	0	0	0	0	0	0	0	1	12970	1285	45	1		1	RABL2A	2	114399705	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	15217509	114399705	128799668	32	14375										
RALB	5899	broad.mit.edu	37	chr2	121043653	121043653	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcctttacagcaactgccgaAttcaggtatgtctgaaatga	8	9	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:121043653A>G	uc002tmk.2	+	3	508	c.318A>G	c.(316-318)GAA>GAG	p.E106E	RALB_uc010yys.1_Silent_p.E128E|RALB_uc002tml.2_Silent_p.E127E|RALB_uc002tmm.2_RNA|RALB_uc010yyt.1_Intron	NM_002881	NP_002872	P11234	RALB_HUMAN	v-ral simian leukemia viral oncogene homolog B	106					apoptosis|cell cycle|cytokinesis|nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of exocyst assembly|regulation of exocyst localization	cytosol|midbody|plasma membrane	GTP binding|GTPase activity|protein binding			lung(3)	3		Prostate(154;0.122)				CAACTGCCGAATTCAGGTATG	0.438													0	0	0	6.4e-05	0	3	79										G	121043653	A	G	121043653	2	3	52	1	0	0	0	0	0	0	0	1	13011	98	4	5		5	RALB	2	121043653	Silent	SNP	A	TCGA-DK-A2I1-01A-11D-A17V-08	6643948	121043653	122155720	33	14376										
NCKAP5	344148	broad.mit.edu	37	chr2	133543046	133543046	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttgcaggggggatactccttGaggctgctacttttaattcc	11	9	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:133543046G>C	uc002ttp.2	-	14	1712	c.1338C>G	c.(1336-1338)CTC>CTG	p.L446L	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	446							protein binding				0						GATACTCCTTGAGGCTGCTAC	0.458													0	0	0	0.000151284	0	14	44										C	133543046	G	C	133543046	2	2	52	1	0	0	0	0	0	0	0	1	10223	1277	45	1		1	NCKAP5	2	133543046	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	12499393	133543046	109656327	34	14377										
GPD2	2820	broad.mit.edu	37	chr2	157406241	157406241	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagacagacccccagacaggGaaagtgcgtgtgagcggcgc	15	11	0	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:157406241G>A	uc002tzf.3	+	7	1143	c.783G>A	c.(781-783)GGG>GGA	p.G261G	GPD2_uc010zch.1_Silent_p.G34G|GPD2_uc002tzd.3_Silent_p.G261G|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	261					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						CCCAGACAGGGAAAGTGCGTG	0.522													0	0	0	0.000157383	0	7	18										A	157406241	G	A	157406241	2	1	52	1	0	0	0	0	0	0	0	1	6606	1161	41	1		1	GPD2	2	157406241	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	23863195	157406241	85793132	35	14378										
SCN3A	6328	broad.mit.edu	37	chr2	165952024	165952024	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agctaaagaatacttatcttCtttttctgctggttgaagtt	7	6	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:165952024C>G	uc002ucx.2	-	25	4920	c.4428G>C	c.(4426-4428)AAG>AAC	p.K1476N	SCN3A_uc010zcy.1_5'Flank|SCN3A_uc002ucy.2_Missense_Mutation_p.K1427N|SCN3A_uc002ucz.2_Missense_Mutation_p.K1427N	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1476						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TACTTATCTTCTTTTTCTGCT	0.338													0	0	0	0.000151284	0	13	53										G	165952024	C	G	165952024	3	3	52	1	0	0	0	0	1	0	0	0	13918	912	32	1	1590	1	SCN3A	2	165952024	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	8545783	165952024	77247349	36	14379										
NAB1	4664	broad.mit.edu	37	chr2	191524441	191524441	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctccccagcagacctgggctCccccgcgtccccaaaggaga	10	19	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:191524441C>T	uc002usb.2	+	4	1111	c.539C>T	c.(538-540)TCC>TTC	p.S180F	NAB1_uc010fsc.2_Missense_Mutation_p.S180F|NAB1_uc010fsd.2_Missense_Mutation_p.S180F|NAB1_uc002usc.2_Missense_Mutation_p.S180F|NAB1_uc010zgh.1_Missense_Mutation_p.S180F	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	180					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			GACCTGGGCTCCCCCGCGTCC	0.632													0	0	0	3.59834e-05	0	6	13										T	191524441	C	T	191524441	3	4	52	1	0	0	0	0	1	0	0	0	10131	855	30	1	541	1	NAB1	2	191524441	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	25572417	191524441	51674932	37	14380										
CXCR1	3577	broad.mit.edu	37	chr2	219029263	219029263	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttaaacagtgtacgcagggtGaatccatagcagaacagcat	10	8	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:219029263G>A	uc002vhc.2	-	2	791	c.672C>T	c.(670-672)TTC>TTT	p.F224F		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	224	Cytoplasmic (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						TACGCAGGGTGAATCCATAGC	0.542													0	0	0	0.000147802	0	29	98										A	219029263	G	A	219029263	2	1	52	1	0	0	0	0	0	0	0	1	4090	1281	45	1		1	CXCR1	2	219029263	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	27504822	219029263	24170110	38	14381										
PSMD1	5707	broad.mit.edu	37	chr2	231947596	231947596	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaatctatgttttttccttaGatcgttagacacggtggcag	10	7	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:231947596G>C	uc002vrn.1	+	13	1545	c.1414_splice	c.e13-1	p.I472_splice	PSMD1_uc002vrm.1_Splice_Site_p.I472_splice|PSMD1_uc010fxu.1_Splice_Site_p.I336_splice	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	TTTTTCCTTAGATCGTTAGAC	0.368													0	0	0	0.000308642	0	13	43										C	231947596	G	C	231947596	5	2	52	1	0	0	0	0	0	0	1	0	12692	956	33	1	1463	1	PSMD1	2	231947596	Splice_Site	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	12918333	231947596	11251777	39	14382										
DNAJB3	414061	broad.mit.edu	37	chr2	234652280	234652280	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cctgaagacgtcggctgggtCgcggaagctgaagacgtact	15	10	0	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:234652280C>T	uc002vuz.2	-	1	382	c.283G>A	c.(283-285)GAC>AAC	p.D95N	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	95					protein folding		heat shock protein binding|unfolded protein binding				0						TCGGCTGGGTCGCGGAAGCTG	0.627													0	0	0	0.000132079	0	17	56										T	234652280	C	T	234652280	3	4	52	1	0	0	0	0	1	0	0	0	4621	884	31	1	158	1	DNAJB3	2	234652280	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2704684	234652280	8547093	40	14383										
RBM44	375316	broad.mit.edu	37	chr2	238726844	238726844	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atcaggcaatagaagataatAcgtccctaaaagttgctcat	7	8	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr2:238726844A>G	uc002vxi.3	+	3	1417	c.1285A>G	c.(1285-1287)ACG>GCG	p.T429A		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	428							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGAAGATAATACGTCCCTAAA	0.373													0	0	0	0.000219431	0	14	38										G	238726844	A	G	238726844	3	3	52	1	0	0	0	0	1	0	0	0	13138	391	14	5	1291	5	RBM44	2	238726844	Missense_Mutation	SNP	A	TCGA-DK-A2I1-01A-11D-A17V-08	4074564	238726844	4472529	41	14384										
CHL1	10752	broad.mit.edu	37	chr3	440699	440699	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgacttctctttctaccacaGaatatgctggtttatatgat	6	8	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:440699G>A	uc003bou.2	+	25	3477	c.3206_splice	c.e25-1	p.E1069_splice	CHL1_uc003bot.2_Splice_Site_p.E1085_splice|CHL1_uc003bow.1_Splice_Site_p.E1069_splice|CHL1_uc011asi.1_Splice_Site_p.K1032_splice	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTCTACCACAGAATATGCTGG	0.348													0	0	0	0.00010058	0	9	207										A	440699	G	A	440699	5	1	52	1	0	0	0	0	0	0	1	0	3349	956	33	1	3347	1	CHL1	3	440699	Splice_Site	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		440699	197581731	42	14385										
THUMPD3	25917	broad.mit.edu	37	chr3	9424928	9424928	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gatgctgttcagtgggatatCtgcaatctgccattgagaac	11	8	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:9424928C>T	uc003bro.3	+	8	1318	c.1170C>T	c.(1168-1170)ATC>ATT	p.I390I	LOC440944_uc003brm.2_Intron|THUMPD3_uc003brn.3_Silent_p.I390I	NM_001114092	NP_001107564	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	390							methyltransferase activity|protein binding|RNA binding			ovary(1)	1	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)		AGTGGGATATCTGCAATCTGC	0.418													0	0	0	9.7654e-05	0	18	128										T	9424928	C	T	9424928	2	4	52	1	0	0	0	0	0	0	0	1	15881	903	32	1		1	THUMPD3	3	9424928	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	8984229	9424928	188597502	43	14386										
TTLL3	26140	broad.mit.edu	37	chr3	9877038	9877038	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagcccctgcttcgattcccCactgcccttgtcctggatcc	7	18	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:9877038C>T	uc003btg.2	+	13	2400	c.2184C>T	c.(2182-2184)CCC>CCT	p.P728P	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_3'UTR|TTLL3_uc003btf.3_3'UTR|TTLL3_uc003bth.3_3'UTR|TTLL3_uc011atj.1_3'UTR|TTLL3_uc003btj.3_3'UTR|TTLL3_uc003bti.3_3'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	728					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					TTCGATTCCCCACTGCCCTTG	0.552													0	0	0	0.000229342	0	23	78										T	9877038	C	T	9877038	2	4	52	1	0	0	0	0	0	0	0	1	16725	581	21	2		2	TTLL3	3	9877038	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	452110	9877038	188145392	44	14387										
C3orf31	132001	broad.mit.edu	37	chr3	11880710	11880710	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	actcaccggtttttggagtcGtccagcaatgtataagttat	9	8	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:11880710G>A	uc003bwh.2	-	3	639	c.397C>T	c.(397-399)CGA>TGA	p.R133*	C3orf31_uc003bwj.2_Nonsense_Mutation_p.R133*|C3orf31_uc003bwi.2_RNA|C3orf31_uc011auo.1_Nonsense_Mutation_p.R133*|C3orf31_uc011aup.1_RNA|C3orf31_uc010hdy.1_RNA	NM_138807	NP_620162	Q96BW9	MMP37_HUMAN	MMP37-like protein, mitochondrial precursor	133					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane					0						TTTTGGAGTCGTCCAGCAATG	0.229													0	0	0	0.000228196	0	35	54										A	11880710	G	A	11880710	4	1	52	1	0	0	0	0	0	1	0	0	2221	1153	40	2	573	2	C3orf31	3	11880710	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2003672	11880710	186141720	45	14388										
ZFYVE20	64145	broad.mit.edu	37	chr3	15115948	15115948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agcataagcaaggtgggtgcGaggctctctgctgggctcca	15	10	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:15115948G>A	uc003bzm.1	-	14	2310	c.1696C>T	c.(1696-1698)CGC>TGC	p.R566C	ZFYVE20_uc010hek.1_Missense_Mutation_p.R566C	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	566	Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						AGGTGGGTGCGAGGCTCTCTG	0.567													0	0	0	0.000274275	0	9	32										A	15115948	G	A	15115948	3	1	52	1	0	0	0	0	1	0	0	0	17663	1058	37	1	662	1	ZFYVE20	3	15115948	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3235238	15115948	182906482	46	14389										
OSBPL10	114884	broad.mit.edu	37	chr3	31921292	31921292	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcattcacaaaatactgcagGatgccagcctcgaaatccag	7	12	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:31921292G>A	uc003cev.2	-	3	693	c.312C>T	c.(310-312)ATC>ATT	p.I104I	OSBPL10_uc011axf.1_Silent_p.I104I	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	104	PH.				lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		AATACTGCAGGATGCCAGCCT	0.478													0	0	0	0.000442599	0	10	46										A	31921292	G	A	31921292	2	1	52	1	0	0	0	0	0	0	0	1	11275	1164	41	1		1	OSBPL10	3	31921292	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	16805344	31921292	166101138	47	14390										
NKTR	4820	broad.mit.edu	37	chr3	42678621	42678621	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaatcttccactcgaagaatGaaatcctcttgtgatagaga	7	8	2	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:42678621G>C	uc003clo.2	+	13	1572	c.1425G>C	c.(1423-1425)ATG>ATC	p.M475I	NKTR_uc003clm.1_Missense_Mutation_p.M222I|NKTR_uc003clp.2_Missense_Mutation_p.M222I|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.M365I|NKTR_uc003clr.1_Missense_Mutation_p.M222I|NKTR_uc003cls.2_Missense_Mutation_p.M175I	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	475	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CTCGAAGAATGAAATCCTCTT	0.393													0	0	0	0.000229342	0	19	67										C	42678621	G	C	42678621	3	2	52	1	0	0	0	0	1	0	0	0	10448	1290	45	1	1471	1	NKTR	3	42678621	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	10757329	42678621	155343809	48	14391										
TDGF1	6997	broad.mit.edu	37	chr3	46621544	46621544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttcctcaggcatttctacccGgctgtggtaagcggaggttc	12	11	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:46621544G>A	uc003cpv.2	+	5	722	c.442G>A	c.(442-444)GGC>AGC	p.G148S	LRRC2_uc003cpu.3_5'UTR	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	148					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		ATTTCTACCCGGCTGTGGTAA	0.547													0	0	0	0.000184323	0	24	37										A	46621544	G	A	46621544	3	1	52	1	0	0	0	0	1	0	0	0	15723	1116	39	2	460	2	TDGF1	3	46621544	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3942923	46621544	151400886	49	14392										
SHISA5	51246	broad.mit.edu	37	chr3	48510922	48510922	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gggcggcacacttggaggctGaggataaggggcatgcacca	17	9	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:48510922G>A	uc003ctp.1	-	5	615	c.481C>T	c.(481-483)CAG>TAG	p.Q161*	SHISA5_uc003ctn.1_Missense_Mutation_p.S29L|SHISA5_uc003ctm.1_Nonsense_Mutation_p.Q58*|SHISA5_uc011bbk.1_Missense_Mutation_p.S69L|SHISA5_uc003cto.1_Nonsense_Mutation_p.Q130*|SHISA5_uc003ctq.1_Nonsense_Mutation_p.Q154*|SHISA5_uc003ctr.1_Nonsense_Mutation_p.Q130*|SHISA5_uc003cts.1_Nonsense_Mutation_p.Q130*|SHISA5_uc003ctt.2_Nonsense_Mutation_p.Q58*|SHISA5_uc003ctu.1_RNA|SHISA5_uc011bbl.1_Nonsense_Mutation_p.Q59*	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	161	Cytoplasmic (Potential).|Pro-rich.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						CTTGGAGGCTGAGGATAAGGG	0.602													0	0	0	0.000157383	0	7	39										A	48510922	G	A	48510922	4	1	52	1	0	0	0	0	0	1	0	0	14283	1299	45	1	249	1	SHISA5	3	48510922	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1889378	48510922	149511508	50	14393										
RHOA	387	broad.mit.edu	37	chr3	49405951	49405951	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	caggcgatcataatcttcctGcccagctgtgtcccacaaag	8	14	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:49405951G>T	uc003cwu.2	-	3	463	c.187C>A	c.(187-189)CAG>AAG	p.Q63K	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	63	GTP (By similarity).			Q->L: Causes constitutive activation.	axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	TAATCTTCCTGCCCAGCTGTG	0.483													1	0	2.79863e-10	9.22233e-05	4.48025e-09	24	93										T	49405951	G	T	49405951	3	4	52	1	0	0	0	0	1	0	0	0	13331	1328	46	4	406	4	RHOA	3	49405951	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	895029	49405951	148616479	51	14394										
SEMA3G	56920	broad.mit.edu	37	chr3	52473745	52473745	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cttcctcaggttcagctgagCcccctgcctggagagcgatg	12	14	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:52473745C>T	uc003dea.1	-	12	1418	c.1418G>A	c.(1417-1419)GGC>GAC	p.G473D		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	473	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		TTCAGCTGAGCCCCCTGCCTG	0.622													0	0	0	0.000157383	0	7	19										T	52473745	C	T	52473745	3	4	52	1	0	0	0	0	1	0	0	0	14030	739	26	2	950	2	SEMA3G	3	52473745	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3067794	52473745	145548685	52	14395										
NT5DC2	64943	broad.mit.edu	37	chr3	52558849	52558849	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcacctcagctcctgccgctCtttcatccaggcagccagca	7	18	4	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:52558849C>T	uc003deo.2	-	13	1709	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K	NT5DC2_uc003dem.2_Missense_Mutation_p.E299K|NT5DC2_uc003den.2_Missense_Mutation_p.E466K|NT5DC2_uc010hmi.2_Missense_Mutation_p.E441K|NT5DC2_uc010hmj.2_Missense_Mutation_p.E245K	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	429							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TCCTGCCGCTCTTTCATCCAG	0.657													0	0	0	0.000274275	0	9	31										T	52558849	C	T	52558849	3	4	52	1	0	0	0	0	1	0	0	0	10691	922	32	1	285	1	NT5DC2	3	52558849	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	85104	52558849	145463581	53	14396										
CACNA1D	776	broad.mit.edu	37	chr3	53804028	53804028	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagtgaaaatgtccctgtccCaactgctacacctggggtaa	9	11	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:53804028C>A	uc003dgv.3	+	31	4062	c.3899C>A	c.(3898-3900)CCA>CAA	p.P1300Q	CACNA1D_uc003dgu.3_Missense_Mutation_p.P1320Q|CACNA1D_uc003dgy.3_Intron|CACNA1D_uc003dgw.3_Missense_Mutation_p.P967Q|CACNA1D_uc003dgx.1_Missense_Mutation_p.P476Q	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1300	Extracellular (Potential).|IV.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GTCCCTGTCCCAACTGCTACA	0.438													1	0	2.17888e-05	0.000442599	0.000339942	8	228										A	53804028	C	A	53804028	3	1	52	1	0	0	0	0	1	0	0	0	2541	594	21	4	4193	4	CACNA1D	3	53804028	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1245179	53804028	144218402	54	14397										
PHLDB2	90102	broad.mit.edu	37	chr3	111603142	111603142	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcctgcaaagagaagcccttCtcctttgggaaccagtgtca	10	12	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:111603142C>T	uc010hqa.2	+	2	629	c.218C>T	c.(217-219)TCT>TTT	p.S73F	PHLDB2_uc003dyc.2_Missense_Mutation_p.S100F|PHLDB2_uc003dyd.2_Missense_Mutation_p.S73F|PHLDB2_uc003dyg.2_Missense_Mutation_p.S73F|PHLDB2_uc003dyh.2_Missense_Mutation_p.S73F|PHLDB2_uc003dye.3_Missense_Mutation_p.S73F|PHLDB2_uc003dyf.3_Missense_Mutation_p.S73F	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	73						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AGAAGCCCTTCTCCTTTGGGA	0.443													0	0	0	0.000147903	0	131	301										T	111603142	C	T	111603142	3	4	52	1	0	0	0	0	1	0	0	0	11852	913	32	1	305	1	PHLDB2	3	111603142	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	57799114	111603142	86419288	55	14398										
WDR52	55779	broad.mit.edu	37	chr3	113114608	113114608	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atgacttacatgagacatggGagaccacattaactgacaca	8	9	0	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:113114608G>C	uc003eae.1	-	15	1925	c.1879C>G	c.(1879-1881)CCC>GCC	p.P627A		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	627										central_nervous_system(1)	1						TGAGACATGGGAGACCACATT	0.343													0	0	0	0.000339439	0	29	104										C	113114608	G	C	113114608	3	2	52	1	0	0	0	0	1	0	0	0	17301	1174	41	1	3784	1	WDR52	3	113114608	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1511466	113114608	84907822	56	14399										
ATP6V1A	523	broad.mit.edu	37	chr3	113505209	113505209	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcctctgttgactggccagaGagtccttgatgccctttttc	9	12	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:113505209G>C	uc003eao.2	+	6	761	c.695G>C	c.(694-696)AGA>ACA	p.R232T	ATP6V1A_uc011bik.1_Missense_Mutation_p.R199T	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	232					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						ACTGGCCAGAGAGTCCTTGAT	0.428													0	0	0	0.000147903	0	168	184										C	113505209	G	C	113505209	3	2	52	1	0	0	0	0	1	0	0	0	1177	942	33	1	713	1	ATP6V1A	3	113505209	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	390601	113505209	84517221	57	14400										
GPR156	165829	broad.mit.edu	37	chr3	119886885	119886885	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aacctgagtctaaatgatcaGaaaagtcttttgagtcagat	8	6	4	5			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:119886885G>T	uc011bjf.1	-	9	1439	c.1439C>A	c.(1438-1440)TCT>TAT	p.S480Y	GPR156_uc011bjg.1_Missense_Mutation_p.S476Y	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	480	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TAAATGATCAGAAAAGTCTTT	0.532													1	0	4.4004e-07	0.00047179	6.94383e-06	25	135										T	119886885	G	T	119886885	3	4	52	1	0	0	0	0	1	0	0	0	6661	942	33	3	1009	3	GPR156	3	119886885	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	6381676	119886885	78135545	58	14401										
NDUFB4	4710	broad.mit.edu	37	chr3	120315335	120315335	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttggccataagagcccagctGaaacgagagtacctgcttca	10	11	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:120315335G>A	uc003edu.2	+	1	208	c.129G>A	c.(127-129)CTG>CTA	p.L43L	NDUFB4_uc003edt.2_Silent_p.L43L	NM_004547	NP_004538	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	43					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	GAGCCCAGCTGAAACGAGAGT	0.632													0	0	0	0.000184323	0	24	23										A	120315335	G	A	120315335	2	1	52	1	0	0	0	0	0	0	0	1	10283	1277	45	1		1	NDUFB4	3	120315335	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	428450	120315335	77707095	59	14402										
XRN1	54464	broad.mit.edu	37	chr3	142122729	142122729	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	actttgtgtctgatgtgtttCagagtaggaaatccacagaa	10	6	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:142122729C>T	uc003eus.2	-	17	2053	c.1986G>A	c.(1984-1986)CTG>CTA	p.L662L	XRN1_uc010huu.2_Silent_p.L128L|XRN1_uc003eut.2_Silent_p.L662L|XRN1_uc003euu.2_Silent_p.L662L|XRN1_uc003euv.1_Silent_p.L523L	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	662					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TGATGTGTTTCAGAGTAGGAA	0.289													0	0	0	0.000586117	0	22	177										T	142122729	C	T	142122729	2	4	52	1	0	0	0	0	0	0	0	1	17456	813	29	1		1	XRN1	3	142122729	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	21807394	142122729	55899701	60	14403										
LXN	56925	broad.mit.edu	37	chr3	158386887	158386887	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	acccaggctaaatgtagaacGagcgtcatttctggagatac	10	9	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:158386887G>A	uc003fch.2	-	4	620	c.405C>T	c.(403-405)CTC>CTT	p.L135L	GFM1_uc003fcd.2_Intron|GFM1_uc003fce.2_Intron|GFM1_uc003fcf.2_Intron|GFM1_uc003fcg.2_Intron|LXN_uc011bov.1_Silent_p.L135L	NM_020169	NP_064554	Q9BS40	LXN_HUMAN	latexin	135						cytoplasm	metalloendopeptidase inhibitor activity|protein binding				0			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			AATGTAGAACGAGCGTCATTT	0.313													0	0	0	0.000175454	0	20	126										A	158386887	G	A	158386887	2	1	52	1	0	0	0	0	0	0	0	1	9089	1045	37	1		1	LXN	3	158386887	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	16264158	158386887	39635543	61	14404										
PLD1	5337	broad.mit.edu	37	chr3	171455826	171455826	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agaggtatttacccgtggctCgtttttcagtgacatgttaa	10	7	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr3:171455826C>T	uc003fhs.2	-	2	132	c.16G>A	c.(16-18)GAG>AAG	p.E6K	PLD1_uc003fht.2_Missense_Mutation_p.E6K	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	6					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACCCGTGGCTCGTTTTTCAGT	0.413													0	0	0	0.000566183	0	16	75										T	171455826	C	T	171455826	3	4	52	1	0	0	0	0	1	0	0	0	12045	893	31	1	3312	1	PLD1	3	171455826	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	13068939	171455826	26566604	62	14405										
GAK	2580	broad.mit.edu	37	chr4	845581	845581	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgctcctcccgcgccccgatCacactgaagttcgaggcata	9	17	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:845581C>T	uc003gbm.3	-	25	3664	c.3465G>A	c.(3463-3465)GTG>GTA	p.V1155V	GAK_uc003gbn.3_Silent_p.V1076V|GAK_uc003gbk.3_5'UTR|GAK_uc010ibi.2_Silent_p.V380V|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Silent_p.V1008V	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1155					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GCGCCCCGATCACACTGAAGT	0.657													0	0	0	0.00010058	0	10	28										T	845581	C	T	845581	2	4	52	1	0	0	0	0	0	0	0	1	6195	813	29	1		1	GAK	4	845581	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		845581	190308695	63	14406										
ADD1	118	broad.mit.edu	37	chr4	2916622	2916622	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	catccacagggagagctggtGacggcctccaaggccatcat	12	13	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:2916622G>C	uc003gfr.2	+	13	1805	c.1617G>C	c.(1615-1617)GTG>GTC	p.V539V	ADD1_uc003gfn.2_Intron|ADD1_uc003gfo.2_Silent_p.V570V|ADD1_uc003gfp.2_Silent_p.V539V|ADD1_uc003gfq.2_Silent_p.V570V|ADD1_uc003gfs.2_Silent_p.V570V	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	539					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GAGAGCTGGTGACGGCCTCCA	0.647													0	0	0	6.4e-05	0	3	78										C	2916622	G	C	2916622	2	2	52	1	0	0	0	0	0	0	0	1	304	1277	45	1		1	ADD1	4	2916622	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2071041	2916622	188237654	64	14407										
KCNIP4	80333	broad.mit.edu	37	chr4	20734378	20734378	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgtacatttacccatcatatCgtatattgctttcattatat	3	8	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:20734378C>T	uc003gqe.2	-	6	601	c.517G>A	c.(517-519)GAT>AAT	p.D173N	KCNIP4_uc003gqf.1_Missense_Mutation_p.D169N|KCNIP4_uc003gqg.1_Missense_Mutation_p.D128N|KCNIP4_uc003gqh.1_Missense_Mutation_p.D165N|KCNIP4_uc003gqi.1_Missense_Mutation_p.D128N|PACRGL_uc003gpu.2_Intron|PACRGL_uc003gpx.3_Intron|PACRGL_uc003gpw.2_Intron|KCNIP4_uc010iel.2_Missense_Mutation_p.D170N|KCNIP4_uc003gqd.3_Missense_Mutation_p.D153N	NM_147182	NP_671711	Q6PIL6	KCIP4_HUMAN	Kv channel interacting protein 4 isoform 3	190	EF-hand 3.					plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)				CCCATCATATCGTATATTGCT	0.378													0	0	0	7.07596e-05	0	17	44										T	20734378	C	T	20734378	3	4	52	1	0	0	0	0	1	0	0	0	8042	884	31	1	196	1	KCNIP4	4	20734378	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	17817756	20734378	170419898	65	14408										
EXOC1	55763	broad.mit.edu	37	chr4	56768579	56768579	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aggaagtaagttaccaacttGcatttaacaaacaagaactt	6	7	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:56768579G>A	uc003hbe.1	+	18	2565	c.2407G>A	c.(2407-2409)GCA>ACA	p.A803T	EXOC1_uc003hbf.1_Missense_Mutation_p.A803T|EXOC1_uc003hbg.1_Missense_Mutation_p.A788T	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	803					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					TTACCAACTTGCATTTAACAA	0.378													0	0	0	0.000295444	0	22	53										A	56768579	G	A	56768579	3	1	52	1	0	0	0	0	1	0	0	0	5301	1319	46	2	2473	2	EXOC1	4	56768579	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	36034201	56768579	134385697	66	14409										
EPHA5	2044	broad.mit.edu	37	chr4	66361157	66361157	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tctcctgaaataatccttttCacagacacaagaggttgaag	7	9	2	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:66361157C>T	uc003hcy.2	-	4	1208	c.1015G>A	c.(1015-1017)GAA>AAA	p.E339K	EPHA5_uc003hcx.2_Missense_Mutation_p.E270K|EPHA5_uc003hcz.2_Missense_Mutation_p.E339K|EPHA5_uc011cah.1_Missense_Mutation_p.E339K|EPHA5_uc011cai.1_Missense_Mutation_p.E339K|EPHA5_uc003hda.2_Missense_Mutation_p.E339K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	339	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TAATCCTTTTCACAGACACAA	0.468										TSP Lung(17;0.13)			0	0	0	6.40141e-05	0	12	131										T	66361157	C	T	66361157	3	4	52	1	0	0	0	0	1	0	0	0	5170	835	29	1	2158	1	EPHA5	4	66361157	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	9592578	66361157	124793119	67	14410										
SEPT11	55752	broad.mit.edu	37	chr4	77926942	77926942	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttggagaccagataaataaaGatgacaggtacatcttggga	11	5	1	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:77926942G>A	uc003hkj.2	+	3	493	c.331G>A	c.(331-333)GAT>AAT	p.D111N	SEPT11_uc010ijh.1_Missense_Mutation_p.D103N|SEPT11_uc011cca.1_Missense_Mutation_p.D121N	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	111					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						GATAAATAAAGATGACAGGTA	0.423													0	0	0	0.000175454	0	20	56										A	77926942	G	A	77926942	3	1	52	1	0	0	0	0	1	0	0	0	14061	942	33	1	341	1	SEPT11	4	77926942	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	11565785	77926942	113227334	68	14411										
ARHGAP24	83478	broad.mit.edu	37	chr4	86915953	86915953	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgggacaagtctgagtcaccCcagagaagcagcatgaacaa	11	10	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:86915953C>A	uc003hpk.2	+	9	1595	c.1146C>A	c.(1144-1146)CCC>CCA	p.P382P	ARHGAP24_uc003hpl.2_Silent_p.P287P|ARHGAP24_uc010ikf.2_Silent_p.P297P|ARHGAP24_uc003hpm.2_Silent_p.P289P	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1	382					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CTGAGTCACCCCAGAGAAGCA	0.502													1	0	1.56989e-16	0.000147903	2.58051e-15	53	88										A	86915953	C	A	86915953	2	1	52	1	0	0	0	0	0	0	0	1	873	610	22	4		4	ARHGAP24	4	86915953	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	8989011	86915953	104238323	69	14412										
RAP1GDS1	5910	broad.mit.edu	37	chr4	99363176	99363176	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagtacaggatttggcttttCtagatgtcgtatccaaactt	8	7	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:99363176C>G	uc003htx.3	+	15	1922	c.1732C>G	c.(1732-1734)CTA>GTA	p.L578V	RAP1GDS1_uc003htw.3_Missense_Mutation_p.L579V|RAP1GDS1_uc003htv.3_Missense_Mutation_p.L578V|RAP1GDS1_uc003htz.3_Missense_Mutation_p.L529V|RAP1GDS1_uc003hty.3_Missense_Mutation_p.L530V|RAP1GDS1_uc003hua.3_Missense_Mutation_p.L487V	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	578							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TTTGGCTTTTCTAGATGTCGT	0.408			T	NUP98	T-ALL								0	0	0	7.07596e-05	0	16	33										G	99363176	C	G	99363176	3	3	52	1	0	0	0	0	1	0	0	0	13039	912	32	1	1793	1	RAP1GDS1	4	99363176	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	12447223	99363176	91791100	70	14413										
CENPE	1062	broad.mit.edu	37	chr4	104070087	104070087	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agatacgcttcttcttagttCatcaatagtttcttggtgtt	7	7	5	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:104070087C>A	uc003hxb.1	-	28	3847	c.3757G>T	c.(3757-3759)GAA>TAA	p.E1253*	CENPE_uc003hxc.1_Nonsense_Mutation_p.E1228*	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1253	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CTTCTTAGTTCATCAATAGTT	0.323													1	0	3.57733e-08	0.000279167	5.69383e-07	31	71										A	104070087	C	A	104070087	4	1	52	1	0	0	0	0	0	1	0	0	3230	835	29	3	4436	3	CENPE	4	104070087	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	4706911	104070087	87084189	71	14414										
TRPC3	7222	broad.mit.edu	37	chr4	122828620	122828620	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gggggccaaagctctcatttGcagggaggatgtacgcaatc	14	9	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:122828620G>T	uc003ieg.2	-	7	1969	c.1895C>A	c.(1894-1896)GCA>GAA	p.A632E	TRPC3_uc010inr.2_Missense_Mutation_p.A504E|TRPC3_uc003ief.2_Missense_Mutation_p.A559E|TRPC3_uc011cgl.1_Missense_Mutation_p.A296E	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	547	Extracellular (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						GCTCTCATTTGCAGGGAGGAT	0.448													1	0	1.95512e-22	0.000147903	3.22332e-21	58	138										T	122828620	G	T	122828620	3	4	52	1	0	0	0	0	1	0	0	0	16576	1319	46	4	894	4	TRPC3	4	122828620	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	18758533	122828620	68325656	72	14415										
SLC25A31	83447	broad.mit.edu	37	chr4	128685476	128685476	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tatgtgtagtatatcctctaGattttgcccgaacccgatta	7	9	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:128685476G>C	uc003ifl.2	+	3	585	c.439G>C	c.(439-441)GAT>CAT	p.D147H		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	147	Solcar 2.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						ATATCCTCTAGATTTTGCCCG	0.378													0	0	0	9.7654e-05	0	17	56										C	128685476	G	C	128685476	3	2	52	1	0	0	0	0	1	0	0	0	14495	942	33	1	449	1	SLC25A31	4	128685476	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	5856856	128685476	62468800	73	14416										
PRMT10	90826	broad.mit.edu	37	chr4	148575529	148575529	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agcatctggtttactggtctGaaggttagcgagggcactac	13	8	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:148575529G>C	uc003ilc.2	-	9	1661	c.1519C>G	c.(1519-1521)CAG>GAG	p.Q507E	PRMT10_uc003ilb.2_Missense_Mutation_p.Q151E|PRMT10_uc003ild.2_Missense_Mutation_p.Q394E	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	507						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						TTACTGGTCTGAAGGTTAGCG	0.383													0	0	0	0.000339439	0	30	82										C	148575529	G	C	148575529	3	2	52	1	0	0	0	0	1	0	0	0	12536	1299	45	1	1034	1	PRMT10	4	148575529	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	19890053	148575529	42578747	74	14417										
RAPGEF2	9693	broad.mit.edu	37	chr4	160264207	160264207	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ataaatacgaaaaactatttCaagatctccaagacctgttt	4	8	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:160264207C>T	uc003iqg.3	+	15	2822	c.2512C>T	c.(2512-2514)CAA>TAA	p.Q838*		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	838	Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		AAAACTATTTCAAGATCTCCA	0.423													0	0	0	0.000308642	0	15	33										T	160264207	C	T	160264207	4	4	52	1	0	0	0	0	0	1	0	0	13044	827	29	1	2570	1	RAPGEF2	4	160264207	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	11688678	160264207	30890069	75	14418										
NAF1	92345	broad.mit.edu	37	chr4	164050300	164050300	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aatgggattattttgtctctGagaaggaaatcctgaagtct	10	5	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:164050300G>C	uc003iqj.2	-	8	1428	c.1234C>G	c.(1234-1236)CAG>GAG	p.Q412E	NAF1_uc010iqw.1_Intron	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	412					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				TTTTGTCTCTGAGAAGGAAAT	0.413													0	0	0	0.000442599	0	9	35										C	164050300	G	C	164050300	3	2	52	1	0	0	0	0	1	0	0	0	10140	1299	45	1	395	1	NAF1	4	164050300	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3786093	164050300	27103976	76	14419										
DDX60	55601	broad.mit.edu	37	chr4	169197306	169197306	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccttttcatcacctgaacagCtatacttaaatctttcgtgg	5	11	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:169197306C>T	uc003irp.2	-	15	2297	c.2005G>A	c.(2005-2007)GCT>ACT	p.A669T		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	669							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		ACCTGAACAGCTATACTTAAA	0.313													0	0	0	6.40141e-05	0	10	56										T	169197306	C	T	169197306	3	4	52	1	0	0	0	0	1	0	0	0	4378	797	28	2	3229	2	DDX60	4	169197306	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	5147006	169197306	21956970	77	14420										
CASP3	836	broad.mit.edu	37	chr4	185552257	185552257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tttatgacacgccatgtcatCatcaacaccactgtctgtct	5	13	5	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr4:185552257C>G	uc003iwh.2	-	7	801	c.538G>C	c.(538-540)GAT>CAT	p.D180H	CASP3_uc003iwg.2_Intron|CASP3_uc003iwi.2_Missense_Mutation_p.D180H	NM_004346	NP_004337	P42574	CASP3_HUMAN	caspase 3 preproprotein	180					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|negative regulation of apoptosis|nerve growth factor receptor signaling pathway|nuclear fragmentation involved in apoptotic nuclear change|proteolysis|response to tumor necrosis factor	cytosol|mitochondrion|nucleoplasm|plasma membrane	cysteine-type endopeptidase activity|protein binding			kidney(1)	1		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.057)|all_hematologic(60;0.0592)		all cancers(43;2.05e-27)|Epithelial(43;4.27e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.04e-11)|Colorectal(24;2e-05)|STAD - Stomach adenocarcinoma(60;2.35e-05)|GBM - Glioblastoma multiforme(59;4.94e-05)|COAD - Colon adenocarcinoma(29;0.00017)|BRCA - Breast invasive adenocarcinoma(30;0.000218)|LUSC - Lung squamous cell carcinoma(40;0.00904)|READ - Rectum adenocarcinoma(43;0.161)	Melatonin(DB01065)|Minocycline(DB01017)|Simvastatin(DB00641)	GCCATGTCATCATCAACACCA	0.418													0	0	0	9.22233e-05	0	21	39										G	185552257	C	G	185552257	3	3	52	1	0	0	0	0	1	0	0	0	2672	826	29	1	303	1	CASP3	4	185552257	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	16354951	185552257	5602019	78	14421										
ADAMTS16	170690	broad.mit.edu	37	chr5	5239847	5239847	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cccggagtatccgcatctatGaaatgaacgtctctacctcc	7	14	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:5239847G>A	uc003jdl.2	+	16	2470	c.2332G>A	c.(2332-2334)GAA>AAA	p.E778K	ADAMTS16_uc003jdk.1_Missense_Mutation_p.E778K	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	778	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CCGCATCTATGAAATGAACGT	0.483													0	0	0	0.000147802	0	29	102										A	5239847	G	A	5239847	3	1	52	1	0	0	0	0	1	0	0	0	261	1291	45	1	2394	1	ADAMTS16	5	5239847	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		5239847	175675413	79	14422										
DNAH5	1767	broad.mit.edu	37	chr5	13913930	13913930	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tacgtcttgagggttgtaaaGatgtctattatcttggcaag	11	5	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:13913930G>A	uc003jfd.2	-	11	1500	c.1458C>T	c.(1456-1458)ATC>ATT	p.I486I	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	486	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GGGTTGTAAAGATGTCTATTA	0.358									Kartagener_syndrome				0	0	0	0.000147903	0	71	77										A	13913930	G	A	13913930	2	1	52	1	0	0	0	0	0	0	0	1	4604	932	33	1		1	DNAH5	5	13913930	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	8674083	13913930	167001330	80	14423										
DNAH5	1767	broad.mit.edu	37	chr5	13923405	13923406	+	Missense_Mutation	DNP	GG	GG	TT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttacctggtggatgttgtcaGgggtgatggctttggaaggg							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:13923405_13923406GG>TT	uc003jfd.2	-	4	463_464	c.421_422CC>AA	c.(421-423)CCT>AAT	p.P141N	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	141	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GATGTTGTCAGGGGTGATGGCT	0.455									Kartagener_syndrome				0	0	0	6.4e-05	0	10	333										TT	13923406	GG	TT	13923405	3	4	52	1	0	0	0	0	1	0	0	0	4604	1000	35	4	13756	4	DNAH5	5	13923405	Missense_Mutation	DNP	GG	TCGA-DK-A2I1-01A-11D-A17V-08	9475	13923405	166991855	81	14424										
RXFP3	51289	broad.mit.edu	37	chr5	33938041	33938041	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcgccgcgagttccgcaaggCgctcaagagcctgctgtggc	15	14	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:33938041C>T	uc003jic.1	+	1	1553	c.1196C>T	c.(1195-1197)GCG>GTG	p.A399V		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	399	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						TTCCGCAAGGCGCTCAAGAGC	0.642													0	0	0	0.000586117	0	23	57										T	33938041	C	T	33938041	3	4	52	1	0	0	0	0	1	0	0	0	13761	768	27	2	1198	2	RXFP3	5	33938041	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	20014636	33938041	146977219	82	14425										
GZMA	3001	broad.mit.edu	37	chr5	54398548	54398548	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atttctggcatcctctctctCagttgtcgtttctctcctgc	6	14	4	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:54398548C>T	uc003jpm.2	+	1	75	c.38C>T	c.(37-39)TCA>TTA	p.S13L		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	13					cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				TCCTCTCTCTCAGTTGTCGTT	0.408													0	0	0	0.000125731	0	43	67										T	54398548	C	T	54398548	3	4	52	1	0	0	0	0	1	0	0	0	6915	838	29	1	40	1	GZMA	5	54398548	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	20460507	54398548	126516712	83	14426										
DDX4	54514	broad.mit.edu	37	chr5	55094377	55094377	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttctcaaaaagagaaaagctCgttgaaattctgcgaaacat	7	7	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:55094377C>G	uc003jqg.3	+	18	1667	c.1593C>G	c.(1591-1593)CTC>CTG	p.L531L	DDX4_uc010ivz.2_Silent_p.L511L|DDX4_uc003jqh.3_Silent_p.L497L|DDX4_uc003jqj.2_Silent_p.L382L	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	531	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GAGAAAAGCTCGTTGAAATTC	0.333													0	0	0	0.000491102	0	35	60										G	55094377	C	G	55094377	2	3	52	1	0	0	0	0	0	0	0	1	4360	871	31	1		1	DDX4	5	55094377	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	695829	55094377	125820883	84	14427										
AGGF1	55109	broad.mit.edu	37	chr5	76351402	76351402	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaaagaattaaagaaaatacGagtaaaatatggtttacagg	8	2	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:76351402G>A	uc003ket.2	+	11	2057	c.1697G>A	c.(1696-1698)CGA>CAA	p.R566Q		NM_018046	NP_060516	Q8N302	AGGF1_HUMAN	angiogenic factor VG5Q	566					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		AAGAAAATACGAGTAAAATAT	0.299													0	0	0	0.000151284	0	12	48										A	76351402	G	A	76351402	3	1	52	1	0	0	0	0	1	0	0	0	382	1058	37	1	1739	1	AGGF1	5	76351402	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	21257025	76351402	104563858	85	14428										
MEF2C	4208	broad.mit.edu	37	chr5	88100568	88100568	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcacagtcacacagcacgctCagctcataagccttcttcat	5	15	6	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:88100568C>T	uc003kjj.2	-	3	778	c.105G>A	c.(103-105)CTG>CTA	p.L35L	MEF2C_uc003kji.2_Silent_p.L35L|MEF2C_uc003kjk.2_Silent_p.L35L|MEF2C_uc003kjm.2_Silent_p.L35L|MEF2C_uc003kjl.2_Silent_p.L35L	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	35	MADS-box.				apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ACAGCACGCTCAGCTCATAAG	0.418										HNSCC(66;0.2)			0	0	0	0.000442599	0	10	42										T	88100568	C	T	88100568	2	4	52	1	0	0	0	0	0	0	0	1	9457	813	29	1		1	MEF2C	5	88100568	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	11749166	88100568	92814692	86	14429										
TTC37	9652	broad.mit.edu	37	chr5	94876439	94876439	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcctctgtactttcagccagGaactgagtcaattttctcca	6	12	4	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:94876439G>A	uc003klb.2	-	8	768	c.498C>T	c.(496-498)TTC>TTT	p.F166F	TTC37_uc010jbf.1_Silent_p.F118F	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	166							binding			ovary(3)|pancreas(1)	4						TTTCAGCCAGGAACTGAGTCA	0.373													0	0	0	0.000147802	0	28	70										A	94876439	G	A	94876439	2	1	52	1	0	0	0	0	0	0	0	1	16702	1165	41	1		1	TTC37	5	94876439	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	6775871	94876439	86038821	87	14430										
RAD50	10111	broad.mit.edu	37	chr5	131927031	131927031	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaccctgcgtaaacttgaccAggagatggagcagttaaacc	11	10	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:131927031A>G	uc003kxi.2	+	10	1955	c.1568A>G	c.(1567-1569)CAG>CGG	p.Q523R	RAD50_uc003kxh.2_Missense_Mutation_p.Q384R	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	523	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAACTTGACCAGGAGATGGAG	0.368								Homologous_recombination					0	0	0	6.4e-05	0	3	47										G	131927031	A	G	131927031	3	3	52	1	0	0	0	0	1	0	0	0	12984	188	7	5	1606	5	RAD50	5	131927031	Missense_Mutation	SNP	A	TCGA-DK-A2I1-01A-11D-A17V-08	37050592	131927031	48988229	88	14431										
ARHGAP26	23092	broad.mit.edu	37	chr5	142500655	142500655	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaagaaacagtagcagccatCatggacatcaaatttcagaa	8	8	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr5:142500655C>G	uc011dbj.1	+	18	1676	c.1641C>G	c.(1639-1641)ATC>ATG	p.I547M	ARHGAP26_uc003lmt.2_Missense_Mutation_p.I547M|ARHGAP26_uc003lmw.2_Missense_Mutation_p.I547M	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	547	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAGCAGCCATCATGGACATCA	0.433													0	0	0	0.000228196	0	40	71										G	142500655	C	G	142500655	3	3	52	1	0	0	0	0	1	0	0	0	875	816	29	1	1711	1	ARHGAP26	5	142500655	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	10573624	142500655	38414605	89	14432										
WDR46	9277	broad.mit.edu	37	chr6	33248750	33248750	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcagctggtggtctaggccaGaggtggccatgtacctggtg	16	9	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:33248750G>C	uc003ods.2	-	11	1174	c.1130C>G	c.(1129-1131)TCT>TGT	p.S377C	WDR46_uc011dra.1_Missense_Mutation_p.S323C	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	377	WD 5.										0						GTCTAGGCCAGAGGTGGCCAT	0.552													0	0	0	6.40141e-05	0	11	34										C	33248750	G	C	33248750	3	2	52	1	0	0	0	0	1	0	0	0	17296	942	33	1	722	1	WDR46	6	33248750	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		33248750	137866317	90	14433										
DNAH8	1769	broad.mit.edu	37	chr6	38810677	38810677	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttaaacataaggatgatattGaggtacataagtgtatacgt	9	3	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:38810677G>C	uc003ooe.1	+	33	4792	c.4192G>C	c.(4192-4194)GAG>CAG	p.E1398Q		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGATGATATTGAGGTACATAA	0.274													0	0	0	0.000147903	0	105	33										C	38810677	G	C	38810677	3	2	52	1	0	0	0	0	1	0	0	0	4607	1291	45	1	4314	1	DNAH8	6	38810677	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	5561927	38810677	132304390	91	14434										
KIF6	221458	broad.mit.edu	37	chr6	39507812	39507813	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagcaaactggatcttttccCcaaaatgctgaagtcctggg					rs142216439		TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:39507812_39507813CC>AA	uc003oot.2	-	13	1706_1707	c.1611_1612GG>TT	c.(1609-1614)TTGGGG>TTTTGG	p.537_538LG>FW	KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Missense_Mutation_p.328_329LG>FW|KIF6_uc011dua.1_Missense_Mutation_p.537_538LG>FW|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	537_538					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GATCTTTTCCCCAAAATGCTGA	0.465													0	0	0	6.4e-05	0	14	443										AA	39507813	CC	AA	39507812	3	1	52	1	0	0	0	0	1	0	0	0	8308	623	22	4	876	4	KIF6	6	39507812	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	697135	39507812	131607255	92	14435										
TRERF1	55809	broad.mit.edu	37	chr6	42224512	42224512	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagagtgcaaagcaaattcaGaattggtccctccacctggc	10	11	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:42224512G>A	uc003osd.2	-	12	3097	c.2534C>T	c.(2533-2535)TCT>TTT	p.S845F	TRERF1_uc011duq.1_Missense_Mutation_p.S762F|TRERF1_uc003osb.2_Missense_Mutation_p.S601F|TRERF1_uc003osc.2_Missense_Mutation_p.S601F|TRERF1_uc003ose.2_Missense_Mutation_p.S865F	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	845	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCAAATTCAGAATTGGTCCC	0.443													0	0	0	0.000147903	0	54	38										A	42224512	G	A	42224512	3	1	52	1	0	0	0	0	1	0	0	0	16472	942	33	1	1096	1	TRERF1	6	42224512	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2716700	42224512	128890555	93	14436										
TRERF1	55809	broad.mit.edu	37	chr6	42224558	42224558	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	actggaacagcacaaattcaGaagattctccactgttggga	9	9	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:42224558G>C	uc003osd.2	-	12	3051	c.2488C>G	c.(2488-2490)CTG>GTG	p.L830V	TRERF1_uc011duq.1_Missense_Mutation_p.L747V|TRERF1_uc003osb.2_Missense_Mutation_p.L586V|TRERF1_uc003osc.2_Missense_Mutation_p.L586V|TRERF1_uc003ose.2_Missense_Mutation_p.L850V	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	830	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CACAAATTCAGAAGATTCTCC	0.463													0	0	0	0.000147903	0	55	28										C	42224558	G	C	42224558	3	2	52	1	0	0	0	0	1	0	0	0	16472	933	33	1	1142	1	TRERF1	6	42224558	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	46	42224558	128890509	94	14437										
GTPBP2	54676	broad.mit.edu	37	chr6	43593155	43593155	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgatgctggaggttcggccaGactgaatctcatgcaggtgg	15	8	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:43593155G>A	uc003ovs.2	-	5	687	c.650C>T	c.(649-651)TCT>TTT	p.S217F	GTPBP2_uc010jyv.2_Missense_Mutation_p.S129F|GTPBP2_uc003ovt.1_Missense_Mutation_p.S217F	NM_019096	NP_061969	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	217							GTP binding|GTPase activity			liver(1)|skin(1)	2	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GGTTCGGCCAGACTGAATCTC	0.592													0	0	0	0.00058488	0	36	79										A	43593155	G	A	43593155	3	1	52	1	0	0	0	0	1	0	0	0	6880	942	33	1	1190	1	GTPBP2	6	43593155	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1368597	43593155	127521912	95	14438										
GCLC	2729	broad.mit.edu	37	chr6	53370630	53370630	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcgaaattctactctccatcCaatgtctgagtttggaggag	9	9	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:53370630C>G	uc003pbw.1	-	11	1649	c.1261G>C	c.(1261-1263)GGA>CGA	p.G421R	GCLC_uc003pbv.1_Missense_Mutation_p.G145R	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	421					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ACTCTCCATCCAATGTCTGAG	0.428													0	0	0	0.000147802	0	24	55										G	53370630	C	G	53370630	3	3	52	1	0	0	0	0	1	0	0	0	6295	603	21	4	676	4	GCLC	6	53370630	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	9777475	53370630	117744437	96	14439										
ZNF292	23036	broad.mit.edu	37	chr6	87970067	87970067	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gttgttcatctagaggcagaCcacgggattggactaagggc	14	8	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:87970067C>T	uc003plm.3	+	8	6761	c.6720C>T	c.(6718-6720)GAC>GAT	p.D2240D		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2240	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAGAGGCAGACCACGGGATTG	0.418													0	0	0	0.000184323	0	31	70										T	87970067	C	T	87970067	2	4	52	1	0	0	0	0	0	0	0	1	17823	506	18	2		2	ZNF292	6	87970067	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	34599437	87970067	83145000	97	14440										
ANKRD6	22881	broad.mit.edu	37	chr6	90340347	90340347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cttgctacccatgaatgaggCagccagatctgatcagcagg	11	11	2	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:90340347C>T	uc003pni.3	+	16	2149	c.1808C>T	c.(1807-1809)GCA>GTA	p.A603V	ANKRD6_uc003pne.3_Missense_Mutation_p.A598V|ANKRD6_uc003pnf.3_Missense_Mutation_p.A568V|ANKRD6_uc011dzy.1_Missense_Mutation_p.A603V|ANKRD6_uc010kcd.2_Missense_Mutation_p.A539V|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_Missense_Mutation_p.A199V|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_Missense_Mutation_p.A199V	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	603							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		ATGAATGAGGCAGCCAGATCT	0.572													0	0	0	8.12818e-05	0	6	20										T	90340347	C	T	90340347	3	4	52	1	0	0	0	0	1	0	0	0	685	710	25	2	1851	2	ANKRD6	6	90340347	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2370280	90340347	80774720	98	14441										
VNN2	8875	broad.mit.edu	37	chr6	133072623	133072623	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtcttcatgtcataatgataCactttgggaccatttggtgc	9	8	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:133072623C>G	uc003qdt.2	-	5	872	c.861G>C	c.(859-861)GTG>GTC	p.V287V	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Silent_p.V234V	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	287	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CATAATGATACACTTTGGGAC	0.408													0	0	0	0.000151284	0	14	44										G	133072623	C	G	133072623	2	3	52	1	0	0	0	0	0	0	0	1	17180	465	17	4		4	VNN2	6	133072623	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	42732276	133072623	38042444	99	14442										
LTV1	84946	broad.mit.edu	37	chr6	144179139	144179139	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccctacatgatgagaggtttGagaaggtaaggtccccacat	11	9	0	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:144179139G>C	uc003qjs.2	+	6	897	c.790G>C	c.(790-792)GAG>CAG	p.E264Q	LTV1_uc003qju.1_Missense_Mutation_p.E49Q|C6orf94_uc010khj.2_5'UTR	NM_032860	NP_116249	Q96GA3	LTV1_HUMAN	LTV1 homolog	264										ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)		TGAGAGGTTTGAGAAGGTAAG	0.423													0	0	0	0.000409698	0	28	15										C	144179139	G	C	144179139	3	2	52	1	0	0	0	0	1	0	0	0	9081	1291	45	1	812	1	LTV1	6	144179139	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	11106516	144179139	26935928	100	14443										
RBM16	22828	broad.mit.edu	37	chr6	155123181	155123181	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tctgcaggccctagatgctgGtcttgttgttcagttgcaag	12	9	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr6:155123181G>C	uc003qqa.2	+	8	915	c.683G>C	c.(682-684)GGT>GCT	p.G228A	RBM16_uc011efj.1_Missense_Mutation_p.G294A|RBM16_uc011efk.1_Missense_Mutation_p.G273A|RBM16_uc003qpz.2_Missense_Mutation_p.G228A|RBM16_uc010kji.2_Missense_Mutation_p.G249A	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	228	Gln-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CTAGATGCTGGTCTTGTTGTT	0.438													0	0	0	0.000602214	0	4	79										C	155123181	G	C	155123181	3	2	52	1	0	0	0	0	1	0	0	0	13118	1261	44	4	709	4	RBM16	6	155123181	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	10944042	155123181	15991886	101	14444										
C7orf28B	221960	broad.mit.edu	37	chr7	6865862	6865862	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccacctcgggagcctcccacGgcccgcccagagacagcagc	11	20	0	1	rs141173433	by1000genomes	TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:6865862G>C	uc003sqx.1	-	1	1	c.-32_splice	c.e1-1		C7orf28B_uc011jxd.1_Splice_Site|C7orf28B_uc003sqy.1_Splice_Site	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960							lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		AGCCTCCCACGGCCCGCCCAG	0.582													0	0	0	3.59834e-05	0	3	14										C	6865862	G	C	6865862	5	2	52	1	0	0	0	0	0	0	1	0	2384	1131	39	4		4	C7orf28B	7	6865862	Splice_Site	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		6865862	152272801	102	14445										
ADCY1	107	broad.mit.edu	37	chr7	45650061	45650061	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagccccctgagaggattttCcacaagatttacatccagag	8	11	0	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:45650061C>G	uc003tne.3	+	3	891	c.873C>G	c.(871-873)TTC>TTG	p.F291L	ADCY1_uc003tnd.2_Missense_Mutation_p.F66L	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	291	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGAGGATTTTCCACAAGATTT	0.542													0	0	0	0.000374591	0	37	85										G	45650061	C	G	45650061	3	3	52	1	0	0	0	0	1	0	0	0	292	854	30	1	883	1	ADCY1	7	45650061	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	38784199	45650061	113488602	103	14446										
RABGEF1	27342	broad.mit.edu	37	chr7	66270179	66270179	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgagacaagctggcctgcatCaccaagtgcagcaagcacat	10	13	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:66270179C>T	uc011kee.1	+	8	1079	c.915C>T	c.(913-915)ATC>ATT	p.I305I	RABGEF1_uc003tvf.2_Silent_p.I164I|RABGEF1_uc003tvg.2_Silent_p.I99I|RABGEF1_uc010lag.2_Silent_p.I291I|RABGEF1_uc003tvh.2_Silent_p.I291I|RABGEF1_uc003tvi.2_Silent_p.I125I	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	508	VPS9.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TGGCCTGCATCACCAAGTGCA	0.458													0	0	0	0.000219431	0	14	61										T	66270179	C	T	66270179	2	4	52	1	0	0	0	0	0	0	0	1	12966	816	29	1		1	RABGEF1	7	66270179	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	20620118	66270179	92868484	104	14447										
PCLO	27445	broad.mit.edu	37	chr7	82580207	82580207	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	acgttcccactccaattcctCagcaaagcgctgttgcttaa	6	14	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:82580207C>T	uc003uhx.2	-	6	9986	c.9697G>A	c.(9697-9699)GAG>AAG	p.E3233K	PCLO_uc003uhv.2_Missense_Mutation_p.E3233K|PCLO_uc010lec.2_Missense_Mutation_p.E198K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3164	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCAATTCCTCAGCAAAGCGC	0.443													0	0	0	0.000228196	0	38	88										T	82580207	C	T	82580207	3	4	52	1	0	0	0	0	1	0	0	0	11583	835	29	1	5828	1	PCLO	7	82580207	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	16310028	82580207	76558456	105	14448										
CCDC132	55610	broad.mit.edu	37	chr7	92978099	92978099	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgcagtcaaaaagccctttCttcagcagttctattctcag	6	12	5	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:92978099C>T	uc003umo.2	+	24	2412	c.2284C>T	c.(2284-2286)CTT>TTT	p.L762F	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.L732F|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Missense_Mutation_p.L482F	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	762											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AAAGCCCTTTCTTCAGCAGTT	0.403													0	0	0	0.000509022	0	42	88										T	92978099	C	T	92978099	3	4	52	1	0	0	0	0	1	0	0	0	2767	913	32	1	2420	1	CCDC132	7	92978099	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	10397892	92978099	66160564	106	14449										
CYP3A7	1551	broad.mit.edu	37	chr7	99306789	99306789	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	acatcttttttgcagaccctCtcaagtctcatagcaactgg	6	12	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:99306789C>G	uc003uru.2	-	11	1227	c.1122G>C	c.(1120-1122)GAG>GAC	p.E374D	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	374					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TGCAGACCCTCTCAAGTCTCA	0.428													0	0	0	9.7654e-05	0	19	106										G	99306789	C	G	99306789	3	3	52	1	0	0	0	0	1	0	0	0	4181	912	32	1	401	1	CYP3A7	7	99306789	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6328690	99306789	59831874	107	14450										
STAG3	10734	broad.mit.edu	37	chr7	99808634	99808634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgtatgcatctgcttggcagGgcctgccaagcctaacagag	12	11	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:99808634G>A	uc003utx.1	+	30	3394	c.3239G>A	c.(3238-3240)GGG>GAG	p.G1080E	STAG3_uc011kjk.1_Missense_Mutation_p.G1022E|GATS_uc003uty.3_Intron|GATS_uc003utz.3_Intron|GATS_uc003uua.3_Intron|GATS_uc010lgt.2_Intron|STAG3_uc003uub.1_Missense_Mutation_p.G304E	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	1080					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGCTTGGCAGGGCCTGCCAAG	0.572													0	0	0	0.000117367	0	27	62										A	99808634	G	A	99808634	3	1	52	1	0	0	0	0	1	0	0	0	15243	1246	43	2	3353	2	STAG3	7	99808634	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	501845	99808634	59330029	108	14451										
MUC17	140453	broad.mit.edu	37	chr7	100677336	100677336	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	caccacactggtggccacttCtgcaatcagcaccctttcaa	6	16	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:100677336C>A	uc003uxp.1	+	3	2692	c.2639C>A	c.(2638-2640)TCT>TAT	p.S880Y	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	880	Extracellular (Potential).|12.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGGCCACTTCTGCAATCAGC	0.498													1	0	2.24612e-69	0.000147903	3.72532e-68	179	355										A	100677336	C	A	100677336	3	1	52	1	0	0	0	0	1	0	0	0	9974	913	32	3	2649	3	MUC17	7	100677336	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	868702	100677336	58461327	109	14452										
FBXL13	222235	broad.mit.edu	37	chr7	102665560	102665560	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aatgtcacattttagagtctCatctacaagaaagacttcag	6	8	4	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:102665560C>T	uc003vaq.2	-	6	872	c.445G>A	c.(445-447)GAG>AAG	p.E149K	FBXL13_uc010liq.1_5'UTR|FBXL13_uc010lir.1_Missense_Mutation_p.E149K|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.E149K|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	149											0						TTTAGAGTCTCATCTACAAGA	0.294													0	0	0	0.000219431	0	14	42										T	102665560	C	T	102665560	3	4	52	1	0	0	0	0	1	0	0	0	5709	835	29	1	1822	1	FBXL13	7	102665560	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1988224	102665560	56473103	110	14453										
PSMC2	5701	broad.mit.edu	37	chr7	102988224	102988224	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagaaggacgacaagcccatCcgaggtcagttgacatgggc	14	10	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:102988224C>T	uc003vbs.2	+	1	136	c.66C>T	c.(64-66)ATC>ATT	p.I22I	DNAJC2_uc003vbo.2_5'Flank|DNAJC2_uc010lix.2_5'Flank|DNAJC2_uc003vbp.2_5'Flank|DNAJC2_uc003vbq.1_5'Flank|DNAJC2_uc003vbr.1_5'Flank|PSMC2_uc011kln.1_Silent_p.I22I|PSMC2_uc011klo.1_5'UTR	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	22					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						ACAAGCCCATCCGAGGTCAGT	0.597													0	0	0	9.7654e-05	0	16	64										T	102988224	C	T	102988224	2	4	52	1	0	0	0	0	0	0	0	1	12686	845	30	1		1	PSMC2	7	102988224	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	322664	102988224	56150439	111	14454										
PUS7	54517	broad.mit.edu	37	chr7	105098242	105098242	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tggacaaggtactgctcagcGaagccaggttgtattcagct	12	9	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:105098242G>A	uc003vcx.2	-	16	2200	c.1981C>T	c.(1981-1983)CGC>TGC	p.R661C	PUS7_uc010lji.2_Missense_Mutation_p.R667C|PUS7_uc003vcy.2_Missense_Mutation_p.R661C|PUS7_uc003vcz.1_Missense_Mutation_p.R661C	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	661					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						ACTGCTCAGCGAAGCCAGGTT	0.448													0	0	0	0.000147903	0	67	323										A	105098242	G	A	105098242	3	1	52	1	0	0	0	0	1	0	0	0	12833	1058	37	1	8	1	PUS7	7	105098242	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2110018	105098242	54040421	112	14455										
EXOC4	60412	broad.mit.edu	37	chr7	133502139	133502139	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccaaacagtgtcctcttcgaGagtttctcaccgtgtacatc	7	13	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:133502139G>C	uc003vrk.2	+	11	1611	c.1576G>C	c.(1576-1578)GAG>CAG	p.E526Q	EXOC4_uc011kpo.1_Missense_Mutation_p.E425Q|EXOC4_uc003vrl.2_Missense_Mutation_p.E136Q|EXOC4_uc011kpp.1_Missense_Mutation_p.E58Q	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	526					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				TCCTCTTCGAGAGTTTCTCAC	0.413													0	0	0	0.000109025	0	31	56										C	133502139	G	C	133502139	3	2	52	1	0	0	0	0	1	0	0	0	5306	943	33	1	1627	1	EXOC4	7	133502139	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	28403897	133502139	25636524	113	14456										
ZNF777	27153	broad.mit.edu	37	chr7	149129613	149129613	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgtgagctgttgcttgtgccGgaagctgatctcgcattcgg	14	10	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr7:149129613G>A	uc003wfv.2	-	6	1913	c.1750C>T	c.(1750-1752)CGG>TGG	p.R584W		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	584	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TGCTTGTGCCGGAAGCTGATC	0.642													0	0	0	0.000602214	0	4	40										A	149129613	G	A	149129613	3	1	52	1	0	0	0	0	1	0	0	0	18147	1115	39	2	749	2	ZNF777	7	149129613	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	15627474	149129613	10009050	114	14457										
PPP3CC	5533	broad.mit.edu	37	chr8	22398214	22398214	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttaatgagcgaatgccacccCgaaaggatagcatacacgct	9	11	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:22398214C>A	uc003xbs.2	+	14	1765	c.1438C>A	c.(1438-1440)CGA>AGA	p.R480R	PPP3CC_uc011kzi.1_Silent_p.R489R|PPP3CC_uc003xbt.2_Silent_p.R470R|PPP3CC_uc011kzj.1_Silent_p.R195R	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma	480					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		AATGCCACCCCGAAAGGATAG	0.517													1	0	0.000602214	0.000602214	0.00908751	5	94										A	22398214	C	A	22398214	2	1	52	1	0	0	0	0	0	0	0	1	12399	644	23	4		4	PPP3CC	8	22398214	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		22398214	123965808	115	14458										
NRG1	3084	broad.mit.edu	37	chr8	31498021	31498021	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgggcggtgaaagccggggGcttgaagaaggactcgctgc	19	8	0	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:31498021G>A	uc003xip.2	+	1	754	c.521G>A	c.(520-522)GGC>GAC	p.G174D		NM_013962	NP_039256	Q02297	NRG1_HUMAN	neuregulin 1 isoform GGF2	Error:Variant_position_missing_in_Q02297_after_alignment					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		AAAGCCGGGGGCTTGAAGAAG	0.706													0	0	0	0.000602214	0	4	16										A	31498021	G	A	31498021	3	1	52	1	0	0	0	0	1	0	0	0	10647	1203	42	2	523	2	NRG1	8	31498021	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	9099807	31498021	114866001	116	14459										
IDO2	169355	broad.mit.edu	37	chr8	39806766	39806766	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tatctgaagagtatggctttCttcttccagattctctggta	8	8	4	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:39806766C>G	uc010lwy.1	+	2	363	c.121C>G	c.(121-123)CTT>GTT	p.L41V	IDO2_uc003xno.1_RNA	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1	28					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2						GTATGGCTTTCTTCTTCCAGA	0.383													0	0	0	0.000442599	0	10	25										G	39806766	C	G	39806766	3	3	52	1	0	0	0	0	1	0	0	0	7502	913	32	1	127	1	IDO2	8	39806766	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	8308745	39806766	106557256	117	14460										
ATP6V1H	51606	broad.mit.edu	37	chr8	54745646	54745647	+	Splice_Site	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcagcagaaatcatctgtccCctagaaagtaagaataagat							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:54745646_54745647CC>AA	uc003xrl.2	-	3	266	c.114_splice	c.e3-1	p.Q38_splice	ATP6V1H_uc003xrk.2_Splice_Site|ATP6V1H_uc003xrm.2_Splice_Site_p.Q38_splice|ATP6V1H_uc003xrn.2_Splice_Site_p.Q38_splice|ATP6V1H_uc011ldv.1_Splice_Site|ATP6V1H_uc010lyd.2_Intron|ATP6V1H_uc003xro.1_Splice_Site_p.Q35_splice	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TCATCTGTCCCCTAGAAAGTAA	0.406													0	0	0	6.4e-05	0	9	250										AA	54745647	CC	AA	54745646	5	1	52	1	0	0	0	0	0	0	1	0	1189	637	22	4	1385	4	ATP6V1H	8	54745646	Splice_Site	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	14938880	54745646	91618376	118	14461										
IMPA1	3612	broad.mit.edu	37	chr8	82593018	82593018	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttttatagcttcacaaactaCctaaaaagaggttttggtaa	6	6	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:82593018C>A	uc003ych.2	-	3	191	c.64G>T	c.(64-66)GTA>TTA	p.V22L	IMPA1_uc011lfq.1_Missense_Mutation_p.V81L|IMPA1_uc011lfr.1_Missense_Mutation_p.V22L	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	22					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)	TCACAAACTACCTAAAAAGAG	0.274													1	0	5.01169e-05	0.000566183	0.000771019	17	157										A	82593018	C	A	82593018	3	1	52	1	0	0	0	0	1	0	0	0	7722	521	18	4	797	4	IMPA1	8	82593018	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	27847372	82593018	63771004	119	14462										
TRPS1	7227	broad.mit.edu	37	chr8	116599486	116599487	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgggtgtatgacggactcccCcgcaggatgtctgcccctct					rs146506752	by1000genomes	TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:116599486_116599487CC>AA	uc003ynz.2	-	4	2861_2862	c.2402_2403GG>TT	c.(2401-2403)CGG>CTT	p.R801L	TRPS1_uc011lhy.1_Missense_Mutation_p.R805L|TRPS1_uc003yny.2_Missense_Mutation_p.R814L|TRPS1_uc010mcy.2_Missense_Mutation_p.R801L	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	801	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ACGGACTCCCCCGCAGGATGTC	0.559									Langer-Giedion_syndrome				0	0	0	6.4e-05	0	13	343										AA	116599487	CC	AA	116599486	3	1	52	1	0	0	0	0	1	0	0	0	16590	610	22	4	1454	4	TRPS1	8	116599486	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	34006468	116599486	29764536	120	14463										
COL14A1	7373	broad.mit.edu	37	chr8	121290778	121290778	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	taactgatggaagatcacaaGatgatgtgaacaaaatctcc	8	7	2	5			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:121290778G>C	uc003yox.2	+	28	3707	c.3442G>C	c.(3442-3444)GAT>CAT	p.D1148H	COL14A1_uc003yoz.2_Missense_Mutation_p.D113H	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1148	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AAGATCACAAGATGATGTGAA	0.358													0	0	0	0.000147903	0	45	40										C	121290778	G	C	121290778	3	2	52	1	0	0	0	0	1	0	0	0	3671	942	33	1	3548	1	COL14A1	8	121290778	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	4691292	121290778	25073244	121	14464										
HAS2	3037	broad.mit.edu	37	chr8	122626946	122626946	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tctcggaagtaggacttgctCcaacgggtctgctggtttag	13	9	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:122626946C>T	uc003yph.2	-	4	1600	c.1062G>A	c.(1060-1062)TGG>TGA	p.W354*		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	354	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AGGACTTGCTCCAACGGGTCT	0.448													0	0	0	0.000117367	0	28	118										T	122626946	C	T	122626946	4	4	52	1	0	0	0	0	0	1	0	0	6962	856	30	1	600	1	HAS2	8	122626946	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1336168	122626946	23737076	122	14465										
FER1L6	654463	broad.mit.edu	37	chr8	125058101	125058102	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgaaggagctggcagagtccCcgcccttagtggtggtggag							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:125058101_125058102CC>AA	uc003yqw.2	+	21	2889_2890	c.2683_2684CC>AA	c.(2683-2685)CCG>AAG	p.P895K		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	895	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGCAGAGTCCCCGCCCTTAGTG	0.55													0	0	0	6.4e-05	0	11	342										AA	125058102	CC	AA	125058101	3	1	52	1	0	0	0	0	1	0	0	0	5815	623	22	4	2761	4	FER1L6	8	125058101	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	2431155	125058101	21305921	123	14466										
DENND3	22898	broad.mit.edu	37	chr8	142200469	142200469	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cagccgcttccagctgccgcGaggtggcctgacgtccatca	12	16	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:142200469G>A	uc003yvy.2	+	20	3370	c.3092G>A	c.(3091-3093)CGA>CAA	p.R1031Q	DENND3_uc010mep.2_Missense_Mutation_p.R992Q|DENND3_uc003ywa.1_Missense_Mutation_p.R81Q|DENND3_uc003ywb.2_Missense_Mutation_p.R81Q	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	1031										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CAGCTGCCGCGAGGTGGCCTG	0.642													0	0	0	0.000308642	0	14	39										A	142200469	G	A	142200469	3	1	52	1	0	0	0	0	1	0	0	0	4432	1058	37	1	3166	1	DENND3	8	142200469	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	17142368	142200469	4163553	124	14467										
ZNF623	9831	broad.mit.edu	37	chr8	144732979	144732979	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttattgaacaccagagaattCacaccggagagagacccttt	8	10	1	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:144732979C>G	uc003yzd.2	+	1	1026	c.937C>G	c.(937-939)CAC>GAC	p.H313D	ZNF623_uc011lkp.1_Missense_Mutation_p.H273D|ZNF623_uc003yzc.2_Missense_Mutation_p.H273D	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	313	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCAGAGAATTCACACCGGAGA	0.468													0	0	0	0.000147903	0	58	72										G	144732979	C	G	144732979	3	3	52	1	0	0	0	0	1	0	0	0	18044	826	29	1	939	1	ZNF623	8	144732979	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2532510	144732979	1631043	125	14468										
PLEC	5339	broad.mit.edu	37	chr8	144993101	144993101	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	accctgctggcggatgatctCtgtcttctcaatgatctcga	9	12	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:144993101C>G	uc003zaf.1	-	32	11469	c.11299G>C	c.(11299-11301)GAG>CAG	p.E3767Q	PLEC_uc003zab.1_Missense_Mutation_p.E3630Q|PLEC_uc003zac.1_Missense_Mutation_p.E3634Q|PLEC_uc003zad.2_Missense_Mutation_p.E3630Q|PLEC_uc003zae.1_Missense_Mutation_p.E3598Q|PLEC_uc003zag.1_Missense_Mutation_p.E3608Q|PLEC_uc003zah.2_Missense_Mutation_p.E3616Q|PLEC_uc003zaj.2_Missense_Mutation_p.E3657Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3767	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGGATGATCTCTGTCTTCTCA	0.612													0	0	0	0.000586117	0	21	115										G	144993101	C	G	144993101	3	3	52	1	0	0	0	0	1	0	0	0	12052	922	32	1	2759	1	PLEC	8	144993101	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	260122	144993101	1370921	126	14469										
PLEC	5339	broad.mit.edu	37	chr8	144994322	144994322	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgcagctctgagtagagctCctcctgccgggcccgagcag	13	15	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr8:144994322C>A	uc003zaf.1	-	32	10248	c.10078G>T	c.(10078-10080)GAG>TAG	p.E3360*	PLEC_uc003zab.1_Nonsense_Mutation_p.E3223*|PLEC_uc003zac.1_Nonsense_Mutation_p.E3227*|PLEC_uc003zad.2_Nonsense_Mutation_p.E3223*|PLEC_uc003zae.1_Nonsense_Mutation_p.E3191*|PLEC_uc003zag.1_Nonsense_Mutation_p.E3201*|PLEC_uc003zah.2_Nonsense_Mutation_p.E3209*|PLEC_uc003zaj.2_Nonsense_Mutation_p.E3250*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3360	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GAGTAGAGCTCCTCCTGCCGG	0.677													1	0	3.86212e-05	3.86212e-05	0.000597493	10	56										A	144994322	C	A	144994322	4	1	52	1	0	0	0	0	0	1	0	0	12052	864	30	3	3980	3	PLEC	8	144994322	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1221	144994322	1369700	127	14470										
PTPRD	5789	broad.mit.edu	37	chr9	8500790	8500790	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aatcaacacggacaagctctCagggccagggccgacatctg	11	13	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:8500790C>T	uc003zkk.2	-	23	2803	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.E698K|PTPRD_uc003zkm.2_Missense_Mutation_p.E685K|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	698	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GACAAGCTCTCAGGGCCAGGG	0.483										TSP Lung(15;0.13)			0	0	0	0.000437636	0	40	43										T	8500790	C	T	8500790	3	4	52	1	0	0	0	0	1	0	0	0	12799	835	29	1	3806	1	PTPRD	9	8500790	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		8500790	132712641	128	14471										
AQP7	364	broad.mit.edu	37	chr9	33386406	33386406	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgggcaggatactcactgtaGaagagactgtagatggtggc	15	7	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:33386406G>C	uc003zst.2	-	5	574	c.402C>G	c.(400-402)TTC>TTG	p.F134L	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Missense_Mutation_p.F77L|AQP7_uc010mjs.2_Missense_Mutation_p.F42L|AQP7_uc010mjt.2_Missense_Mutation_p.F42L|AQP7_uc011lnx.1_Missense_Mutation_p.F134L|AQP7_uc011lny.1_Missense_Mutation_p.F133L|AQP7_uc003zss.3_Missense_Mutation_p.F42L|AQP7_uc011lnz.1_Missense_Mutation_p.F42L|AQP7_uc011loa.1_Missense_Mutation_p.F42L	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	134	Helical; (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		ACTCACTGTAGAAGAGACTGT	0.577													0	0	0	0.00024832	0	4	23										C	33386406	G	C	33386406	3	2	52	1	0	0	0	0	1	0	0	0	831	933	33	1	642	1	AQP7	9	33386406	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	24885616	33386406	107827025	129	14472										
AQP7	364	broad.mit.edu	37	chr9	33387057	33387057	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gctcccatattttttatttaGaaccatatgggccacggaac	7	10	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:33387057G>C	uc003zst.2	-	4	350	c.178C>G	c.(178-180)CTA>GTA	p.L60V	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Missense_Mutation_p.L3V|AQP7_uc010mjs.2_Intron|AQP7_uc010mjt.2_Intron|AQP7_uc011lnx.1_Missense_Mutation_p.L60V|AQP7_uc011lny.1_Missense_Mutation_p.L59V|AQP7_uc003zss.3_Intron|AQP7_uc011lnz.1_Intron|AQP7_uc011loa.1_Intron	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	60	Extracellular (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		TTTTTATTTAGAACCATATGG	0.567													0	0	0	3.59834e-05	0	5	50										C	33387057	G	C	33387057	3	2	52	1	0	0	0	0	1	0	0	0	831	933	33	1	870	1	AQP7	9	33387057	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	651	33387057	107826374	130	14473										
ANKRD20A4	728747	broad.mit.edu	37	chr9	69420374	69420375	+	Missense_Mutation	DNP	GG	GG	TT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	taacccaacaaagaaagattGggaaaacgtatcctcagcaa							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:69420374_69420375GG>TT	uc004afn.2	+	13	1376_1377	c.1264_1265GG>TT	c.(1264-1266)GGG>TTG	p.G422L		NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	422											0						AAGAAAGATTGGGAAAACGTAT	0.342													0	0	0	6.4e-05	0	9	354										TT	69420375	GG	TT	69420374	3	4	52	1	0	0	0	0	1	0	0	0	650	1348	47	4	1314	4	ANKRD20A4	9	69420374	Missense_Mutation	DNP	GG	TCGA-DK-A2I1-01A-11D-A17V-08	36033317	69420374	71793057	131	14474										
APBA1	320	broad.mit.edu	37	chr9	72047530	72047530	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctctgtccattgatttcaatGatccggtgccccacacggac	8	14	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:72047530G>A	uc004ahh.2	-	12	2640	c.2364C>T	c.(2362-2364)ATC>ATT	p.I788I		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	788	PDZ 2.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						TGATTTCAATGATCCGGTGCC	0.582													0	0	0	0.000147903	0	51	6										A	72047530	G	A	72047530	2	1	52	1	0	0	0	0	0	0	0	1	756	1280	45	1		1	APBA1	9	72047530	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2627156	72047530	69165901	132	14475										
RASEF	158158	broad.mit.edu	37	chr9	85677430	85677430	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgggactcgccgggccgcacGaggtggccagcgccgccgcc	17	18	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:85677430G>T	uc004amo.1	-	1	614	c.353C>A	c.(352-354)TCG>TAG	p.S118*	RASEF_uc004amp.1_Nonsense_Mutation_p.S118*	NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	118					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding	p.S118L(1)		upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						CGGGCCGCACGAGGTGGCCAG	0.721													1	0	2.23348e-06	0.000422831	3.49449e-05	13	19										T	85677430	G	T	85677430	4	4	52	1	0	0	0	0	0	1	0	0	13068	1059	37	3	1937	3	RASEF	9	85677430	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	13629900	85677430	55536001	133	14476										
COL15A1	1306	broad.mit.edu	37	chr9	101800955	101800955	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tttttctcttttcagtccttGatcaatatcacccatggatt	4	10	4	1	rs139652646	byFrequency	TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:101800955G>C	uc004azb.1	+	22	2621	c.2415G>C	c.(2413-2415)TTG>TTC	p.L805F		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	805	Nonhelical region 4 (NC4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TTCAGTCCTTGATCAATATCA	0.463													0	0	0	0.000437636	0	37	228										C	101800955	G	C	101800955	3	2	52	1	0	0	0	0	1	0	0	0	3672	1281	45	1	2501	1	COL15A1	9	101800955	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	16123525	101800955	39412476	134	14477										
ERP44	23071	broad.mit.edu	37	chr9	102861077	102861077	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctcactcaccaggagcagaaGggagcatctgaggtcgggta	14	10	3	2	rs140289515		TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:102861077G>A	uc004bam.2	-	1	254	c.46C>T	c.(46-48)CTT>TTT	p.L16F	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Missense_Mutation_p.L16F|INVS_uc010mta.1_5'Flank|INVS_uc011lve.1_5'Flank|INVS_uc004bao.1_5'Flank|INVS_uc004bap.1_5'Flank|INVS_uc004baq.1_5'Flank|INVS_uc004bar.1_5'Flank|INVS_uc010mtb.1_5'Flank	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	16					cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0						AGGAGCAGAAGGGAGCATCTG	0.572													0	0	0	3.59834e-05	0	6	36										A	102861077	G	A	102861077	3	1	52	1	0	0	0	0	1	0	0	0	5243	1000	35	2	1222	2	ERP44	9	102861077	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1060122	102861077	38352354	135	14478										
LAMC3	10319	broad.mit.edu	37	chr9	133945103	133945103	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgcctcggcccagtgccacGagaacggcacatgcgtgtgc	13	15	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:133945103G>A	uc004caa.1	+	17	3033	c.2935G>A	c.(2935-2937)GAG>AAG	p.E979K		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	979	Laminin EGF-like 11.			E -> Y (in Ref. 1; AAD36991).	cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CCAGTGCCACGAGAACGGCAC	0.662													0	0	0	0.000151284	0	14	13										A	133945103	G	A	133945103	3	1	52	1	0	0	0	0	1	0	0	0	8616	1059	37	1	3001	1	LAMC3	9	133945103	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	31084026	133945103	7268328	136	14479										
COL5A1	1289	broad.mit.edu	37	chr9	137591828	137591828	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggcagccaggccttcctggtCtccatctacaacgagcaggg	12	14	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr9:137591828C>T	uc004cfe.2	+	3	733	c.351C>T	c.(349-351)GTC>GTT	p.V117V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	117	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCTTCCTGGTCTCCATCTACA	0.587													0	0	0	0.000151284	0	13	83										T	137591828	C	T	137591828	2	4	52	1	0	0	0	0	0	0	0	1	3696	900	32	1		1	COL5A1	9	137591828	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3646725	137591828	3621603	137	14480										
FBXO18	84893	broad.mit.edu	37	chr10	5959443	5959443	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggaagctgggggagtgcacaGaagaggcgcaccagatgact	17	8	0	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:5959443G>C	uc001iis.2	+	11	1944	c.1849G>C	c.(1849-1851)GAA>CAA	p.E617Q	FBXO18_uc001iir.2_Missense_Mutation_p.E543Q|FBXO18_uc009xig.2_Missense_Mutation_p.E543Q|FBXO18_uc001iit.2_Missense_Mutation_p.E668Q	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	617					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GGAGTGCACAGAAGAGGCGCA	0.577													0	0	0	0.00047179	0	22	43										C	5959443	G	C	5959443	3	2	52	1	0	0	0	0	1	0	0	0	5731	943	33	1	2053	1	FBXO18	10	5959443	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		5959443	129575304	138	14481										
DCLRE1C	64421	broad.mit.edu	37	chr10	14974951	14974951	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	catgtctagcttattcacatGaacctaaggcaaataataca	5	9	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:14974951G>C	uc001inn.2	-	9	767	c.682C>G	c.(682-684)CAT>GAT	p.H228D	DCLRE1C_uc010qbx.1_Missense_Mutation_p.H228D|DCLRE1C_uc001inl.2_Missense_Mutation_p.H108D|DCLRE1C_uc009xji.2_Missense_Mutation_p.H113D|DCLRE1C_uc001inm.2_Missense_Mutation_p.H108D|DCLRE1C_uc001ino.2_Missense_Mutation_p.H113D|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Missense_Mutation_p.H108D|DCLRE1C_uc001inq.2_Missense_Mutation_p.H108D|DCLRE1C_uc001inr.2_Missense_Mutation_p.H113D|DCLRE1C_uc009xjj.1_RNA	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	228					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						TTATTCACATGAACCTAAGGC	0.393								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					0	0	0	0.000132079	0	19	171										C	14974951	G	C	14974951	3	2	52	1	0	0	0	0	1	0	0	0	4296	1290	45	1	1420	1	DCLRE1C	10	14974951	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	9015508	14974951	120559796	139	14482										
CACNB2	783	broad.mit.edu	37	chr10	18803285	18803285	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctccaaagagaaaagaatgcCcttctttaagaaggtaacat	7	8	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:18803285C>G	uc001ipr.2	+	7	851	c.791C>G	c.(790-792)CCC>CGC	p.P264R	CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Intron|CACNB2_uc001ipt.2_Intron|CACNB2_uc010qcl.1_Intron|CACNB2_uc001ipu.2_Missense_Mutation_p.P236R|CACNB2_uc001ipv.2_Intron|CACNB2_uc009xka.1_Intron|CACNB2_uc001ipw.2_Intron|CACNB2_uc001ipx.2_Missense_Mutation_p.P209R|CACNB2_uc009xkb.1_Intron|CACNB2_uc010qcm.1_Missense_Mutation_p.P210R|CACNB2_uc001ipz.2_Intron|CACNB2_uc001ipy.2_Missense_Mutation_p.P210R|CACNB2_uc010qcn.1_Intron|CACNB2_uc010qco.1_Intron|CACNB2_uc001iqa.2_Missense_Mutation_p.P216R|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	264					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAAAGAATGCCCTTCTTTAAG	0.468													0	0	0	0.000339439	0	29	142										G	18803285	C	G	18803285	3	3	52	1	0	0	0	0	1	0	0	0	2553	623	22	4	1037	4	CACNB2	10	18803285	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3828334	18803285	116731462	140	14483										
SYT15	83849	broad.mit.edu	37	chr10	46967615	46967615	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcctcctgctcatattccacCgagaaccacagccgccccag	7	19	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:46967615C>T	uc001jea.2	-	4	615	c.462G>A	c.(460-462)TCG>TCA	p.S154S	SYT15_uc001jdz.2_Silent_p.S154S|SYT15_uc001jeb.2_Silent_p.S32S|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	154	Cytoplasmic (Potential).|C2 1.					integral to membrane|plasma membrane					0						CATATTCCACCGAGAACCACA	0.622													0	0	0	0.000274275	0	9	95										T	46967615	C	T	46967615	2	4	52	1	0	0	0	0	0	0	0	1	15468	639	23	2		2	SYT15	10	46967615	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	28164330	46967615	88567132	141	14484										
C10orf81	79949	broad.mit.edu	37	chr10	115534019	115534019	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttgcttccagtgattctggtGaatccattgaaactgatggt	10	7	1	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:115534019G>T	uc001lat.1	+	8	1250	c.688G>T	c.(688-690)GAA>TAA	p.E230*	C10orf81_uc001lar.1_Nonsense_Mutation_p.E236*|C10orf81_uc009xyc.1_Nonsense_Mutation_p.E148*|C10orf81_uc001las.1_Nonsense_Mutation_p.E148*|C10orf81_uc001lau.1_Nonsense_Mutation_p.E50*	NM_024889	NP_079165	Q5SXH7	CJ081_HUMAN	hypothetical protein LOC79949	230										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		TGATTCTGGTGAATCCATTGA	0.378													1	0	2.47316e-13	0.00058488	3.98229e-12	33	45										T	115534019	G	T	115534019	4	4	52	1	0	0	0	0	0	1	0	0	1619	1291	45	3	736	3	C10orf81	10	115534019	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	68566404	115534019	20000728	142	14485										
FAM160B1	57700	broad.mit.edu	37	chr10	116602857	116602857	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aattggaagatgagcctcctCatcagatggatcacctgtcc	9	11	3	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:116602857C>A	uc001lcb.2	+	6	1023	c.688C>A	c.(688-690)CAT>AAT	p.H230N	FAM160B1_uc001lcc.2_Missense_Mutation_p.H230N	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	230										lung(1)	1						TGAGCCTCCTCATCAGATGGA	0.473													1	0	1.99824e-07	0.000566183	3.17134e-06	18	64										A	116602857	C	A	116602857	3	1	52	1	0	0	0	0	1	0	0	0	5470	826	29	3	710	3	FAM160B1	10	116602857	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1068838	116602857	18931890	143	14486										
FAM160B1	57700	broad.mit.edu	37	chr10	116602895	116602895	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccacaagcttggataacctCagtgtcacctcactgccaga	7	14	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:116602895C>T	uc001lcb.2	+	6	1061	c.726C>T	c.(724-726)CTC>CTT	p.L242L	FAM160B1_uc001lcc.2_Silent_p.L242L	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	242										lung(1)	1						TGGATAACCTCAGTGTCACCT	0.438													0	0	0	0.000175454	0	20	72										T	116602895	C	T	116602895	2	4	52	1	0	0	0	0	0	0	0	1	5470	813	29	1		1	FAM160B1	10	116602895	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	38	116602895	18931852	144	14487										
UROS	7390	broad.mit.edu	37	chr10	127505020	127505020	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	acttaccctgatatacggatCctggccacagtcatcttcct	6	14	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr10:127505020C>G	uc001liw.3	-	1	182	c.49G>C	c.(49-51)GAT>CAT	p.D17H	UROS_uc001liv.3_5'Flank|UROS_uc010quh.1_5'Flank|UROS_uc001lix.3_Missense_Mutation_p.D17H|UROS_uc001liy.3_RNA|UROS_uc001liz.2_5'Flank	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	17					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				ATATACGGATCCTGGCCACAG	0.502													0	0	0	0.000566183	0	17	91										G	127505020	C	G	127505020	3	3	52	1	0	0	0	0	1	0	0	0	17027	855	30	1	784	1	UROS	10	127505020	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	10902125	127505020	8029727	145	14488										
OSBPL5	114879	broad.mit.edu	37	chr11	3111812	3111812	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gacaaagtcaccatcctgctCctcgtctgagagctctgggc	10	14	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:3111812C>T	uc001lxk.2	-	20	2532	c.2374G>A	c.(2374-2376)GAG>AAG	p.E792K	OSBPL5_uc010qxq.1_Missense_Mutation_p.E703K|OSBPL5_uc009ydw.2_Missense_Mutation_p.E724K|OSBPL5_uc001lxl.2_Missense_Mutation_p.E724K|OSBPL5_uc001lxj.2_Missense_Mutation_p.E246K	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	792					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCATCCTGCTCCTCGTCTGAG	0.682													0	0	0	0.000566183	0	16	33										T	3111812	C	T	3111812	3	4	52	1	0	0	0	0	1	0	0	0	11280	864	30	1	277	1	OSBPL5	11	3111812	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		3111812	131894704	146	14489										
SPTY2D1	144108	broad.mit.edu	37	chr11	18637037	18637037	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gctgggtcttgatttcttctCagcatgaggaaggggcattc	13	8	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:18637037C>T	uc001moy.2	-	3	1000	c.784G>A	c.(784-786)GAG>AAG	p.E262K	SPTY2D1_uc010rdi.1_Missense_Mutation_p.E262K	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	262										breast(1)	1						GATTTCTTCTCAGCATGAGGA	0.483													0	0	0	0.000147903	0	50	33										T	18637037	C	T	18637037	3	4	52	1	0	0	0	0	1	0	0	0	15125	835	29	1	1289	1	SPTY2D1	11	18637037	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	15525225	18637037	116369479	147	14490										
BBOX1	8424	broad.mit.edu	37	chr11	27148986	27148986	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtatcttaaggcagagggtgGagaatggaaactgaagtcac	14	5	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:27148986G>A	uc001mre.1	+	9	1518	c.1150G>A	c.(1150-1152)GAG>AAG	p.E384K	BBOX1_uc009yih.1_Missense_Mutation_p.E384K|BBOX1_uc001mrg.1_Missense_Mutation_p.E384K	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	384					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	GCAGAGGGTGGAGAATGGAAA	0.413													0	0	0	0.000132079	0	19	50										A	27148986	G	A	27148986	3	1	52	1	0	0	0	0	1	0	0	0	1334	1175	41	1	1176	1	BBOX1	11	27148986	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	8511949	27148986	107857530	148	14491										
QSER1	79832	broad.mit.edu	37	chr11	32975498	32975498	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgcagttaagcaagaacctCtccactctacttcatatgca	6	12	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:32975498C>G	uc001mty.2	+	5	4153	c.3886C>G	c.(3886-3888)CTC>GTC	p.L1296V	QSER1_uc001mtz.1_Missense_Mutation_p.L1057V|QSER1_uc001mua.2_Missense_Mutation_p.L801V	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1296										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					gcaagaacctctccactctac	0.333													0	0	0	0.000442599	0	9	17										G	32975498	C	G	32975498	3	3	52	1	0	0	0	0	1	0	0	0	12882	913	32	1	3896	1	QSER1	11	32975498	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	5826512	32975498	102031018	149	14492										
HIPK3	10114	broad.mit.edu	37	chr11	33308267	33308267	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cagctcaggcacagcaagctCacgtgcaggcacctcagatt	10	14	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:33308267C>T	uc001mul.1	+	2	577	c.307C>T	c.(307-309)CAC>TAC	p.H103Y	HIPK3_uc001mum.1_Missense_Mutation_p.H103Y|HIPK3_uc009yjv.1_Missense_Mutation_p.H103Y	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	103					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						ACAGCAAGCTCACGTGCAGGC	0.502													0	0	0	9.7654e-05	0	19	19										T	33308267	C	T	33308267	3	4	52	1	0	0	0	0	1	0	0	0	7118	826	29	1	309	1	HIPK3	11	33308267	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	332769	33308267	101698249	150	14493										
SPI1	6688	broad.mit.edu	37	chr11	47397226	47397226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gctgagataggggtaatactCgtgcgtttggcgttggtata	15	5	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:47397226C>T	uc001nfc.1	-	2	323	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SPI1_uc001nfb.1_Missense_Mutation_p.E35K|SLC39A13_uc001nfd.2_Intron|SPI1_uc009ylp.1_Missense_Mutation_p.E28K	NM_003120	NP_003111	P17947	SPI1_HUMAN	hematopoietic transcription factor PU.1 isoform	34					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of erythrocyte differentiation	nucleus	protein binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)	2				Lung(87;0.0967)		GGGTAATACTCGTGCGTTTGG	0.622													0	0	0	0.000147903	0	44	36										T	47397226	C	T	47397226	3	4	52	1	0	0	0	0	1	0	0	0	15048	893	31	1	728	1	SPI1	11	47397226	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	14088959	47397226	87609290	151	14494										
MS4A3	932	broad.mit.edu	37	chr11	59828720	59828720	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaggcgggaccagaagagctGaatacttctgtctaccagcc	12	11	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:59828720G>C	uc001nom.2	+	2	215	c.87G>C	c.(85-87)CTG>CTC	p.L29L	MS4A3_uc001non.2_Silent_p.L29L|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	29	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				CAGAAGAGCTGAATACTTCTG	0.478													0	0	0	0.000132358	0	37	70										C	59828720	G	C	59828720	2	2	52	1	0	0	0	0	0	0	0	1	9861	1277	45	1		1	MS4A3	11	59828720	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	12431494	59828720	75177796	152	14495										
CD6	923	broad.mit.edu	37	chr11	60785351	60785351	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cagtgagtcgagcacctcttCaggggaggattactgcaata	12	9	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:60785351C>T	uc001nqq.2	+	11	1926	c.1703C>T	c.(1702-1704)TCA>TTA	p.S568L	CD6_uc001nqp.2_Missense_Mutation_p.S568L|CD6_uc001nqr.2_Missense_Mutation_p.S536L|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.S527L	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	568	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						AGCACCTCTTCAGGGGAGGAT	0.567													0	0	0	0.000375601	0	22	61										T	60785351	C	T	60785351	3	4	52	1	0	0	0	0	1	0	0	0	3028	838	29	1	1745	1	CD6	11	60785351	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	956631	60785351	74221165	153	14496										
HRASLS2	54979	broad.mit.edu	37	chr11	63320520	63320520	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cctgctgccacacctactgtCgtgactgcaccagtgacctg	9	16	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:63320520C>T	uc001nxg.1	-	4	464	c.405G>A	c.(403-405)ACG>ACA	p.T135T		NM_017878	NP_060348	Q9NWW9	HRSL2_HUMAN	HRAS-like suppressor 2	135					lipid catabolic process	cytoplasm	acyltransferase activity|hydrolase activity				0						CACCTACTGTCGTGACTGCAC	0.562													0	0	0	9.22233e-05	0	27	95										T	63320520	C	T	63320520	2	4	52	1	0	0	0	0	0	0	0	1	7350	871	31	1		1	HRASLS2	11	63320520	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2535169	63320520	71685996	154	14497										
PLCB3	5331	broad.mit.edu	37	chr11	64032897	64032897	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagcatcagcggaaggcagtCaccctcacccgccgcctgct	10	17	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:64032897C>T	uc001nzb.2	+	25	2958	c.2958C>T	c.(2956-2958)GTC>GTT	p.V986V	PLCB3_uc009ypg.1_Silent_p.V986V|PLCB3_uc009yph.1_Silent_p.V919V|PLCB3_uc009ypi.2_Silent_p.V986V	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	986					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GGAAGGCAGTCACCCTCACCC	0.682													0	0	0	3.86212e-05	0	8	19										T	64032897	C	T	64032897	2	4	52	1	0	0	0	0	0	0	0	1	12029	813	29	1		1	PLCB3	11	64032897	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	712377	64032897	70973619	155	14498										
SLC29A2	3177	broad.mit.edu	37	chr11	66134019	66134019	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gctactttctggggactactGggaatcccgttctcatctgg	11	11	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:66134019G>T	uc001oht.2	-	8	979	c.750C>A	c.(748-750)CCC>CCA	p.P250P	SLC29A2_uc001ohs.2_Silent_p.P130P|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Silent_p.P130P|SLC29A2_uc001ohu.2_Silent_p.P250P|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	250					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						GGGGACTACTGGGAATCCCGT	0.582													1	0	6.40141e-05	6.40141e-05	0.000982083	10	35										T	66134019	G	T	66134019	2	4	52	1	0	0	0	0	0	0	0	1	14535	1335	47	4		4	SLC29A2	11	66134019	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2101122	66134019	68872497	156	14499										
ANKRD13D	338692	broad.mit.edu	37	chr11	67059207	67059207	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggccggaggagcttcatcttCaagggccagggtgagctctg	16	10	4	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:67059207C>T	uc001okc.1	+	6	781	c.270C>T	c.(268-270)TTC>TTT	p.F90F	ANKRD13D_uc001okd.1_Silent_p.F177F|ANKRD13D_uc001oke.1_Silent_p.F90F	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	90										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GCTTCATCTTCAAGGGCCAGG	0.612													0	0	0	0.000157383	0	7	42										T	67059207	C	T	67059207	2	4	52	1	0	0	0	0	0	0	0	1	644	825	29	1		1	ANKRD13D	11	67059207	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	925188	67059207	67947309	157	14500										
USP35	57558	broad.mit.edu	37	chr11	77919932	77919932	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atttccccagagaacttcctCtccgcatcctggacgccctg	7	17	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:77919932C>G	uc009yva.1	+	9	1761	c.1515C>G	c.(1513-1515)CTC>CTG	p.L505L	USP35_uc001oze.2_Silent_p.L261L|USP35_uc001ozc.2_Silent_p.L73L|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Silent_p.L116L|USP35_uc001ozf.2_Silent_p.L236L	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	505					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			AGAACTTCCTCTCCGCATCCT	0.622													0	0	0	0.000147903	0	53	98										G	77919932	C	G	77919932	2	3	52	1	0	0	0	0	0	0	0	1	17063	900	32	1		1	USP35	11	77919932	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	10860725	77919932	57086584	158	14501										
DYNC2H1	79659	broad.mit.edu	37	chr11	103152912	103152912	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tatttttattcaataggaatGggatacgtttacaggtgtgg	11	3	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:103152912G>T	uc001pho.2	+	72	10910	c.10766G>T	c.(10765-10767)TGG>TTG	p.W3589L	DYNC2H1_uc001phn.1_Missense_Mutation_p.W3596L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3589					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CAATAGGAATGGGATACGTTT	0.284													1	0	5.01169e-05	0.000566183	0.000771019	13	83										T	103152912	G	T	103152912	3	4	52	1	0	0	0	0	1	0	0	0	4846	1357	47	4	11077	4	DYNC2H1	11	103152912	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	25232980	103152912	31853604	159	14502										
PIH1D2	120379	broad.mit.edu	37	chr11	111941994	111941994	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggattgtaggcaacatcaatGactgtgtaagcatctgtgtg	12	6	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:111941994G>A	uc001pmq.3	-	4	397	c.315C>T	c.(313-315)GTC>GTT	p.V105V	PIH1D2_uc009yyl.2_Silent_p.V105V|PIH1D2_uc001pmp.3_Silent_p.V105V|PIH1D2_uc010rws.1_Silent_p.V105V|C11orf57_uc001pmu.2_5'Flank|C11orf57_uc001pmw.3_5'Flank|C11orf57_uc001pmt.3_5'Flank|C11orf57_uc001pmr.3_5'Flank|C11orf57_uc001pmv.3_5'Flank|C11orf57_uc001pms.3_5'Flank	NM_138789	NP_620144	Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2 isoform 1	105										ovary(1)	1		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		CAACATCAATGACTGTGTAAG	0.358													0	0	0	0.000191422	0	34	149										A	111941994	G	A	111941994	2	1	52	1	0	0	0	0	0	0	0	1	11907	1277	45	1		1	PIH1D2	11	111941994	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	8789082	111941994	23064522	160	14503										
SCN4B	6330	broad.mit.edu	37	chr11	118023348	118023348	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccaaaagcccagtgcccagcCatctcgccggggctttgcct	10	17	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:118023348C>T	uc001pse.2	-	1	283	c.41G>A	c.(40-42)TGG>TAG	p.W14*	SCN4B_uc010rxv.1_Nonsense_Mutation_p.W14*	NM_174934	NP_777594	Q8IWT1	SCN4B_HUMAN	sodium channel, voltage-gated, type IV, beta	14						voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.33e-05)|Epithelial(105;0.00126)		AGTGCCCAGCCATCTCGCCGG	0.662													0	0	0	3.86212e-05	0	8	19										T	118023348	C	T	118023348	4	4	52	1	0	0	0	0	0	1	0	0	13921	595	21	2	665	2	SCN4B	11	118023348	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6081354	118023348	16983168	161	14504										
PRDM10	56980	broad.mit.edu	37	chr11	129817136	129817136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctcatcttcctcagtgtcctCgtcctcatcctcatcctctt	3	18	6	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr11:129817136C>T	uc001qfm.2	-	5	656	c.424G>A	c.(424-426)GAG>AAG	p.E142K	PRDM10_uc001qfj.2_Missense_Mutation_p.E56K|PRDM10_uc001qfk.2_Missense_Mutation_p.E56K|PRDM10_uc001qfl.2_Missense_Mutation_p.E56K|PRDM10_uc010sbx.1_Missense_Mutation_p.E56K|PRDM10_uc001qfn.2_Missense_Mutation_p.E142K|PRDM10_uc009zct.1_Missense_Mutation_p.E174K	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TCAGTGTCCTCGTCCTCATCC	0.582													0	0	0	0.000228196	0	37	38										T	129817136	C	T	129817136	3	4	52	1	0	0	0	0	1	0	0	0	12451	893	31	1	3130	1	PRDM10	11	129817136	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	11793788	129817136	5189380	162	14505										
NOP2	4839	broad.mit.edu	37	chr12	6670928	6670928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgggcaacatgctggaggctCcctgcagcatgtagtgccca	13	13	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:6670928C>T	uc001qph.1	-	11	1277	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	NOP2_uc009zeq.1_Missense_Mutation_p.G82E|NOP2_uc001qpi.1_Missense_Mutation_p.G366E|NOP2_uc001qpj.1_Intron	NM_001033714	NP_001028886	P46087	NOP2_HUMAN	nucleolar protein 1, 120kDa	370					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						GCTGGAGGCTCCCTGCAGCAT	0.607													0	0	0	0.000274275	0	9	9										T	6670928	C	T	6670928	3	4	52	1	0	0	0	0	1	0	0	0	10538	855	30	1	1353	1	NOP2	12	6670928	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		6670928	127180967	163	14506										
CHD4	1108	broad.mit.edu	37	chr12	6692229	6692229	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaagtcttcatcaccttcctCtgaagccactgagtaatcgg	7	12	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:6692229C>G	uc001qpo.2	-	27	4275	c.4111G>C	c.(4111-4113)GAG>CAG	p.E1371Q	CHD4_uc001qpn.2_Missense_Mutation_p.E1364Q|CHD4_uc001qpp.2_Missense_Mutation_p.E1396Q|uc001qpq.1_3'UTR|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1371					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCACCTTCCTCTGAAGCCACT	0.498													0	0	0	0.000229342	0	22	76										G	6692229	C	G	6692229	3	3	52	1	0	0	0	0	1	0	0	0	3327	922	32	1	1683	1	CHD4	12	6692229	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	21301	6692229	127159666	164	14507										
CHD4	1108	broad.mit.edu	37	chr12	6692529	6692529	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgtttaatgatttcccgttCtacctcctcttcctcctggg	6	14	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:6692529C>G	uc001qpo.2	-	26	4059	c.3895G>C	c.(3895-3897)GAA>CAA	p.E1299Q	CHD4_uc001qpn.2_Missense_Mutation_p.E1292Q|CHD4_uc001qpp.2_Missense_Mutation_p.E1296Q|uc001qpq.1_3'UTR|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1299	Poly-Glu.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATTTCCCGTTCTACCTCCTCT	0.532													0	0	0	0.000374591	0	40	166										G	6692529	C	G	6692529	3	3	52	1	0	0	0	0	1	0	0	0	3327	922	32	1	1903	1	CHD4	12	6692529	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	300	6692529	127159366	165	14508										
DENND5B	160518	broad.mit.edu	37	chr12	31604993	31604993	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaaacggttagcaaagacctCtcggagctgtacattgagct	10	9	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:31604993C>T	uc001rki.1	-	5	1696	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K	DENND5B_uc001rkh.1_Missense_Mutation_p.E539K|DENND5B_uc009zjq.1_Intron|DENND5B_uc001rkj.2_Missense_Mutation_p.E526K|DENND5B_uc001rkk.1_Missense_Mutation_p.E426K	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	504	dDENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GCAAAGACCTCTCGGAGCTGT	0.463													0	0	0	0.000437636	0	40	136										T	31604993	C	T	31604993	3	4	52	1	0	0	0	0	1	0	0	0	4437	922	32	1	2382	1	DENND5B	12	31604993	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	24912464	31604993	102246902	166	14509										
RPAP3	79657	broad.mit.edu	37	chr12	48061621	48061621	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaaacaacttaggatacaaaGatggttcaatttgcttgaaa	8	5	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:48061621G>C	uc001rpr.2	-	15	1843	c.1727C>G	c.(1726-1728)TCT>TGT	p.S576C	RPAP3_uc010slk.1_Missense_Mutation_p.S417C|RPAP3_uc001rps.2_Missense_Mutation_p.S542C	NM_024604	NP_078880	Q9H6T3	RPAP3_HUMAN	RNA polymerase II associated protein 3 isoform	576							binding			ovary(1)	1	Lung SC(27;0.192)					AGGATACAAAGATGGTTCAAT	0.294													0	0	0	0.000442599	0	9	40										C	48061621	G	C	48061621	3	2	52	1	0	0	0	0	1	0	0	0	13543	942	33	1	282	1	RPAP3	12	48061621	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	16456628	48061621	85790274	167	14510										
MLL2	8085	broad.mit.edu	37	chr12	49420060	49420060	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgttgttctcaccaatagaaCagcgatagcagcagcgacga	10	11	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:49420060C>A	uc001rta.3	-	48	15689	c.15689G>T	c.(15688-15690)TGT>TTT	p.C5230F		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5230	FYR N-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACCAATAGAACAGCGATAGCA	0.582			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	5.8336e-16	0.00058488	9.56053e-15	33	47										A	49420060	C	A	49420060	3	1	52	1	0	0	0	0	1	0	0	0	9621	478	17	4	952	4	MLL2	12	49420060	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1358439	49420060	84431835	168	14511										
DIP2B	57609	broad.mit.edu	37	chr12	51074507	51074508	+	Missense_Mutation	DNP	GG	GG	TT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tacacacttcttaataaactGgggaccaaaaatgaacctgt							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:51074507_51074508GG>TT	uc001rwv.2	+	9	1323_1324	c.1167_1168GG>TT	c.(1165-1170)CTGGGG>CTTTGG	p.G390W		NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	390						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TTAATAAACTGGGGACCAAAAA	0.342													0	0	0	6.4e-05	0	12	509										TT	51074508	GG	TT	51074507	3	4	52	1	0	0	0	0	1	0	0	0	4528	1335	47	4	1201	4	DIP2B	12	51074507	Missense_Mutation	DNP	GG	TCGA-DK-A2I1-01A-11D-A17V-08	1654447	51074507	82777388	169	14512										
CSRNP2	81566	broad.mit.edu	37	chr12	51467662	51467662	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgctcacgcagaatctctcGatggttcacctcctgttcct	8	14	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:51467662G>A	uc001rxu.1	-	3	653	c.355C>T	c.(355-357)CGA>TGA	p.R119*		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	119					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGAATCTCTCGATGGTTCACC	0.532													0	0	0	0.000147903	0	52	93										A	51467662	G	A	51467662	4	1	52	1	0	0	0	0	0	1	0	0	3964	1066	37	1	1288	1	CSRNP2	12	51467662	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	393155	51467662	82384233	170	14513										
KRT75	9119	broad.mit.edu	37	chr12	52822425	52822425	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cttcttgacgctgtcaatctCagctctcagcctctggatca	7	14	6	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:52822425C>T	uc001saj.2	-	6	1160	c.1138G>A	c.(1138-1140)GAG>AAG	p.E380K		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	380	Coil 2.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		CTGTCAATCTCAGCTCTCAGC	0.507													0	0	0	0.00010058	0	11	54										T	52822425	C	T	52822425	3	4	52	1	0	0	0	0	1	0	0	0	8488	835	29	1	533	1	KRT75	12	52822425	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1354763	52822425	81029470	171	14514										
KRT71	112802	broad.mit.edu	37	chr12	52943818	52943818	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	actcctcctgctcacctcttCttgtagtcctccactacgtc	4	18	3	0	rs140770876		TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:52943818C>G	uc001sao.2	-	2	721	c.651G>C	c.(649-651)AAG>AAC	p.K217N		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	217	Coil 1B.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		CTCACCTCTTCTTGTAGTCCT	0.592													0	0	0	0.000175454	0	19	99										G	52943818	C	G	52943818	3	3	52	1	0	0	0	0	1	0	0	0	8484	912	32	1	952	1	KRT71	12	52943818	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	121393	52943818	80908077	172	14515										
HNRNPA1	3178	broad.mit.edu	37	chr12	54675662	54675662	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaggaggtggatgcagctatGaatgcaaggccacacaaggt	15	7	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:54675662G>A	uc001sfl.2	+	3	320	c.216G>A	c.(214-216)ATG>ATA	p.M72I	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.M72I|HNRNPA1_uc009zng.2_Missense_Mutation_p.M72I|HNRNPA1_uc009znh.2_Missense_Mutation_p.M72I|HNRNPA1_uc009zni.2_Missense_Mutation_p.M72I|HNRNPA1_uc001sfn.2_Missense_Mutation_p.M72I|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.M27I|HNRNPA1_uc009znj.1_Missense_Mutation_p.M27I	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	72	Globular A domain.|RRM 1.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						ATGCAGCTATGAATGCAAGGC	0.463													0	0	0	7.07596e-05	0	18	39										A	54675662	G	A	54675662	3	1	52	1	0	0	0	0	1	0	0	0	7257	1290	45	1	226	1	HNRNPA1	12	54675662	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1731844	54675662	79176233	173	14516										
ZBTB39	9880	broad.mit.edu	37	chr12	57397508	57397508	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cacatgtcgcaggagaaaagGaaaataccaatgtgggacag	12	7	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:57397508G>A	uc001sml.1	-	2	1280	c.1194C>T	c.(1192-1194)TTC>TTT	p.F398F	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						AGGAGAAAAGGAAAATACCAA	0.512													0	0	0	0.000491102	0	35	44										A	57397508	G	A	57397508	2	1	52	1	0	0	0	0	0	0	0	1	17537	1165	41	1		1	ZBTB39	12	57397508	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2721846	57397508	76454387	174	14517										
LRP1	4035	broad.mit.edu	37	chr12	57606238	57606239	+	Frame_Shift_Ins	INS	-	-	G													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgtatgccacactctacatINSggggggccatggcagtcgcc							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:57606238_57606239insG	uc001snd.2	+	89	14001_14002	c.13535_13536insG	c.(13534-13536)ATGfs	p.M4512fs		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	4512	Cytoplasmic (Potential).|Interaction with MAFB (By similarity).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACACTCTACATGGGGGGCCATG	0.644																		19	1896	---	---								G	57606239	-	G	57606238	7	5	52	1	0	1	1	0	0	0	0	0	8951	1464	51	0	13889	0	LRP1	12	57606238	Frame_Shift_Ins	INS	-	TCGA-DK-A2I1-01A-11D-A17V-08	208730	57606238	76245657	175	14518										
TBK1	29110	broad.mit.edu	37	chr12	64868152	64868152	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tagaccctttgaagggcctcGtaggaataaagaagtgatgt	12	6	0	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:64868152G>A	uc001ssc.1	+	6	745	c.683G>A	c.(682-684)CGT>CAT	p.R228H		NM_013254	NP_037386	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	228	Protein kinase.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)		GAAGGGCCTCGTAGGAATAAA	0.383													0	0	0	0.000159656	0	35	142										A	64868152	G	A	64868152	3	1	52	1	0	0	0	0	1	0	0	0	15634	1145	40	2	701	2	TBK1	12	64868152	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	7261914	64868152	68983743	176	14519										
CHST11	50515	broad.mit.edu	37	chr12	105151419	105151419	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcaggagtgggcagctacctGaagttccccacctatgcaaa	11	12	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:105151419G>A	uc001tkx.1	+	4	1188	c.897G>A	c.(895-897)CTG>CTA	p.L299L	CHST11_uc001tky.2_Silent_p.L294L|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	299	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						GCAGCTACCTGAAGTTCCCCA	0.512													0	0	0	3.86212e-05	0	11	37										A	105151419	G	A	105151419	2	1	52	1	0	0	0	0	0	0	0	1	3399	1277	45	1		1	CHST11	12	105151419	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	40283267	105151419	28700476	177	14520										
BTBD11	121551	broad.mit.edu	37	chr12	108034099	108034099	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctattccagatcctcattttCttaacaataaagaaatgtct	3	9	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:108034099C>G	uc001tmk.1	+	13	3270	c.2749C>G	c.(2749-2751)CTT>GTT	p.L917V	BTBD11_uc001tmj.2_Missense_Mutation_p.L917V|BTBD11_uc001tml.1_Missense_Mutation_p.L454V|BTBD11_uc001tmm.1_5'UTR	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	917						integral to membrane	DNA binding			skin(2)|ovary(1)	3						TCCTCATTTTCTTAACAATAA	0.348													0	0	0	0.000151284	0	13	75										G	108034099	C	G	108034099	3	3	52	1	0	0	0	0	1	0	0	0	1539	913	32	1	2904	1	BTBD11	12	108034099	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2882680	108034099	25817796	178	14521										
NCOR2	9612	broad.mit.edu	37	chr12	124968284	124968284	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccccagctcgggcaggtatGagtgggactctggccgcagg	16	12	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr12:124968284G>C	uc010tba.1	-	3	386	c.269C>G	c.(268-270)TCA>TGA	p.S90*	NCOR2_uc010tay.1_Nonsense_Mutation_p.S90*|NCOR2_uc010taz.1_Nonsense_Mutation_p.S90*|NCOR2_uc010tbb.1_Nonsense_Mutation_p.S90*|NCOR2_uc010tbc.1_Nonsense_Mutation_p.S90*|NCOR2_uc001ugj.1_Nonsense_Mutation_p.S90*|NCOR2_uc001ugk.1_Nonsense_Mutation_p.S90*|uc001ugl.2_RNA	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	90					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GGGCAGGTATGAGTGGGACTC	0.632													0	0	0	6.4e-05	0	2	6										C	124968284	G	C	124968284	4	2	52	1	0	0	0	0	0	1	0	0	10236	1294	45	1	7479	1	NCOR2	12	124968284	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	16934185	124968284	8883611	179	14522										
POLR1D	51082	broad.mit.edu	37	chr13	28239829	28239829	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cctccccaccccaggatgaaGtgtcctcttgctagcaccaa	7	17	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:28239829G>A	uc001urp.2	+	3	226	c.108G>A	c.(106-108)AAG>AAA	p.K36K	POLR1D_uc010aam.2_Silent_p.K8K|POLR1D_uc001urq.2_RNA	NM_152705	NP_689918	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D isoform 2	Error:Variant_position_missing_in_Q9Y2S0_after_alignment					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		CCAGGATGAAGTGTCCTCTTG	0.403													0	0	0	0.000422831	0	15	37										A	28239829	G	A	28239829	2	1	52	1	0	0	0	0	0	0	0	1	12212	1020	36	2		2	POLR1D	13	28239829	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		28239829	86930049	180	14523										
USPL1	10208	broad.mit.edu	37	chr13	31231851	31231851	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgcctcagctgaaacagcctCagtaactcaccctaaagata	6	13	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:31231851C>T	uc001utc.2	+	9	2069	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	USPL1_uc001utd.2_Missense_Mutation_p.S217L|USPL1_uc001ute.1_Missense_Mutation_p.S217L	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	546					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		GAAACAGCCTCAGTAACTCAC	0.433													0	0	0	0.00058488	0	35	118										T	31231851	C	T	31231851	3	4	52	1	0	0	0	0	1	0	0	0	17089	838	29	1	1667	1	USPL1	13	31231851	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2992022	31231851	83938027	181	14524										
POSTN	10631	broad.mit.edu	37	chr13	38158988	38158988	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tatctcaattgtatttccttCcagcgtctcaaagactgctc	5	12	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:38158988C>G	uc001uwo.3	-	8	1091	c.973G>C	c.(973-975)GAA>CAA	p.E325Q	POSTN_uc001uwp.3_Missense_Mutation_p.E325Q|POSTN_uc001uwr.2_Missense_Mutation_p.E325Q|POSTN_uc001uwq.2_Missense_Mutation_p.E325Q|POSTN_uc010teu.1_Missense_Mutation_p.E325Q|POSTN_uc010tev.1_Missense_Mutation_p.E325Q|POSTN_uc010tew.1_Missense_Mutation_p.E325Q|POSTN_uc010tex.1_Missense_Mutation_p.E240Q	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	325	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GTATTTCCTTCCAGCGTCTCA	0.378													0	0	0	0.000151284	0	12	76										G	38158988	C	G	38158988	3	3	52	1	0	0	0	0	1	0	0	0	12259	864	30	1	1601	1	POSTN	13	38158988	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6927137	38158988	77010890	182	14525										
DGKH	160851	broad.mit.edu	37	chr13	42742882	42742882	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agttcttggctggggaggttCatatgacgatgacacccaac	12	9	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:42742882C>T	uc001uyl.1	+	11	1316	c.1295C>T	c.(1294-1296)TCA>TTA	p.S432L	DGKH_uc010tfh.1_Missense_Mutation_p.S432L|DGKH_uc001uym.1_Missense_Mutation_p.S432L|DGKH_uc010tfi.1_Missense_Mutation_p.S187L|DGKH_uc010tfj.1_Missense_Mutation_p.S287L|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.S287L|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	432	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TGGGGAGGTTCATATGACGAT	0.468													0	0	0	0.000339439	0	30	116										T	42742882	C	T	42742882	3	4	52	1	0	0	0	0	1	0	0	0	4470	838	29	1	1337	1	DGKH	13	42742882	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	4583894	42742882	72426996	183	14526										
SLC25A30	253512	broad.mit.edu	37	chr13	45971416	45971417	+	In_Frame_Ins	INS	-	-	TAA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atattccaaggaccaagtctINScaaccaatttggccaaaagc							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:45971416_45971417insTAA	uc001vag.2	-	9	947_948	c.810_811insTTA	c.(808-813)insTTA	p.270_271insL	SLC25A30_uc010tfs.1_In_Frame_Ins_p.195_196insL|SLC25A30_uc001vah.2_In_Frame_Ins_p.195_196insL|SLC25A30_uc010tft.1_In_Frame_Ins_p.219_220insL|SLC25A30_uc001vaf.2_3'UTR	NM_001010875	NP_001010875	Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	270_271	Solcar 3.|Helical; Name=6; (Potential).				mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		GGACCAAGTCTCAACCAATTTG	0.307																		40	78	---	---								TAA	45971417	-	TAA	45971416	7	5	52	1	0	1	1	0	0	0	0	0	14494	1559	54	0	72	0	SLC25A30	13	45971416	In_Frame_Ins	INS	-	TCGA-DK-A2I1-01A-11D-A17V-08	3228534	45971416	69198462	184	14527										
PCDH9	5101	broad.mit.edu	37	chr13	67799716	67799716	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tttcacggaaactggagtgtCtggtttgagatgaaaagcag	13	5	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:67799716C>T	uc001vik.2	-	2	3549	c.2857G>A	c.(2857-2859)GAC>AAC	p.D953N	PCDH9_uc001vil.2_Missense_Mutation_p.D953N|PCDH9_uc010thl.1_Missense_Mutation_p.D953N|PCDH9_uc001vin.3_Missense_Mutation_p.D953N	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	953	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACTGGAGTGTCTGGTTTGAGA	0.512													0	0	0	0.000270559	0	37	134										T	67799716	C	T	67799716	3	4	52	1	0	0	0	0	1	0	0	0	11518	913	32	1	872	1	PCDH9	13	67799716	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	21828300	67799716	47370162	185	14528										
COL4A1	1282	broad.mit.edu	37	chr13	110864269	110864270	+	Splice_Site	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cccgagcggccctctctcccCctggggagacagcagagcat							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:110864269_110864270CC>AA	uc001vqw.3	-	7	510	c.388_splice	c.e7-1	p.G130_splice	COL4A1_uc010agl.2_Splice_Site_p.G130_splice	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein						angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTCTCTCCCCCTGGGGAGACA	0.53													0	0	0	6.4e-05	0	10	200										AA	110864270	CC	AA	110864269	5	1	52	1	0	0	0	0	0	0	1	0	3689	637	22	4	4805	4	COL4A1	13	110864269	Splice_Site	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	43064553	110864269	4305609	186	14529										
SOX1	6656	broad.mit.edu	37	chr13	112722232	112722232	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gatcagcaagcgcctgggggCcgagtggaaggtcatgtccg	17	10	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr13:112722232C>A	uc001vsb.1	+	1	320	c.260C>A	c.(259-261)GCC>GAC	p.A87D		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	87	HMG box.				chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		CGCCTGGGGGCCGAGTGGAAG	0.642													1	0	1.26484e-09	0.000157383	2.019e-08	6	27										A	112722232	C	A	112722232	3	1	52	1	0	0	0	0	1	0	0	0	14940	739	26	4	262	4	SOX1	13	112722232	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1857963	112722232	2447646	187	14530										
RPGRIP1	57096	broad.mit.edu	37	chr14	21780097	21780097	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcttgaagagccaactggaaGatgtgtctatcttgcagatg	12	7	2	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:21780097G>A	uc001wag.2	+	8	1045	c.1045G>A	c.(1045-1047)GAT>AAT	p.D349N		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	349	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CCAACTGGAAGATGTGTCTAT	0.443													0	0	0	0.000157383	0	7	14										A	21780097	G	A	21780097	3	1	52	1	0	0	0	0	1	0	0	0	13549	942	33	1	1075	1	RPGRIP1	14	21780097	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		21780097	85569443	188	14531										
MYH7	4625	broad.mit.edu	37	chr14	23884264	23884264	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atgcccttcaccgactctgcGttgcgcttctgctcggcctc	9	17	3	0	rs3729831		TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:23884264G>A	uc001wjx.2	-	37	5605	c.5499C>T	c.(5497-5499)AAC>AAT	p.N1833N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1833	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCGACTCTGCGTTGCGCTTCT	0.652													0	0	0	0.000147903	0	76	50										A	23884264	G	A	23884264	2	1	52	1	0	0	0	0	0	0	0	1	10039	1136	40	2		2	MYH7	14	23884264	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2104167	23884264	83465276	189	14532										
ARHGAP5	394	broad.mit.edu	37	chr14	32562188	32562188	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agcccaattcctgccaataaGgacttatcagaagctgactt	7	11	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:32562188G>A	uc001wrl.2	+	2	2552	c.2313G>A	c.(2311-2313)AAG>AAA	p.K771K	ARHGAP5_uc001wrm.2_Silent_p.K771K|ARHGAP5_uc001wrn.2_Silent_p.K771K|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	771					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CTGCCAATAAGGACTTATCAG	0.398													0	0	0	0.000132079	0	18	71										A	32562188	G	A	32562188	2	1	52	1	0	0	0	0	0	0	0	1	886	991	35	2		2	ARHGAP5	14	32562188	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	8677924	32562188	74787352	190	14533										
RALGAPA1	253959	broad.mit.edu	37	chr14	36147182	36147182	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	catctggtgtctgaagaacaGagtggtggagcttctcgtcg	14	8	3	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:36147182G>C	uc001wti.2	-	21	3471	c.3080C>G	c.(3079-3081)TCT>TGT	p.S1027C	RALGAPA1_uc001wtj.2_Missense_Mutation_p.S1027C|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S1040C|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1074C|RALGAPA1_uc001wtk.1_Missense_Mutation_p.S925C	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1027					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CTGAAGAACAGAGTGGTGGAG	0.433													0	0	0	7.07596e-05	0	15	37										C	36147182	G	C	36147182	3	2	52	1	0	0	0	0	1	0	0	0	13013	942	33	1	3263	1	RALGAPA1	14	36147182	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3584994	36147182	71202358	191	14534										
RALGAPA1	253959	broad.mit.edu	37	chr14	36219784	36219784	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaagaaaccagccaacgaatGacaataacacgagccttaat	6	10	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:36219784G>A	uc001wti.2	-	9	1306	c.915C>T	c.(913-915)GTC>GTT	p.V305V	RALGAPA1_uc001wtj.2_Silent_p.V305V|RALGAPA1_uc010tpv.1_Silent_p.V305V|RALGAPA1_uc010tpw.1_Silent_p.V305V|RALGAPA1_uc001wtk.1_Silent_p.V156V	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	305					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GCCAACGAATGACAATAACAC	0.418													0	0	0	0.000219431	0	12	24										A	36219784	G	A	36219784	2	1	52	1	0	0	0	0	0	0	0	1	13013	1277	45	1		1	RALGAPA1	14	36219784	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	72602	36219784	71129756	192	14535										
RPL10L	140801	broad.mit.edu	37	chr14	47120421	47120421	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcgtcagcattaaacttcgtGaagccccacttcttggagat	8	11	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:47120421G>A	uc001wwg.2	-	1	608	c.519C>T	c.(517-519)TTC>TTT	p.F173F		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	173					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						TAAACTTCGTGAAGCCCCACT	0.512													0	0	0	0.000147903	0	59	58										A	47120421	G	A	47120421	2	1	52	1	0	0	0	0	0	0	0	1	13556	1281	45	1		1	RPL10L	14	47120421	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	10900637	47120421	60229119	193	14536										
C14orf101	54916	broad.mit.edu	37	chr14	57099827	57099827	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gttcctttggagattgtattCaaccctgaggaatggattaa	10	6	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr14:57099827C>G	uc001xcm.2	+	13	1784	c.1662C>G	c.(1660-1662)TTC>TTG	p.F554L	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_Missense_Mutation_p.F87L|C14orf101_uc001xco.2_Missense_Mutation_p.F87L	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	554						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		AGATTGTATTCAACCCTGAGG	0.373													0	0	0	0.000374591	0	42	24										G	57099827	C	G	57099827	3	3	52	1	0	0	0	0	1	0	0	0	1734	825	29	1	1712	1	C14orf101	14	57099827	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	9979406	57099827	50249713	194	14537										
FMN1	342184	broad.mit.edu	37	chr15	33192256	33192257	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtccccgagtcctatttcctCcattcatataatttccaaaa							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:33192256_33192257CC>AA	uc001zhf.3	-	10	2908_2909	c.2908_2909GG>TT	c.(2908-2910)GGA>TTA	p.G970L		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1193	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CCTATTTCCTCCATTCATATAA	0.411													0	0	0	6.4e-05	0	10	287										AA	33192257	CC	AA	33192256	3	1	52	1	0	0	0	0	1	0	0	0	5949	855	30	3	713	3	FMN1	15	33192256	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08		33192256	69339136	195	14538										
RTF1	23168	broad.mit.edu	37	chr15	41749923	41749923	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cttccagttcagattcagacTcttcctcagaagatgaagag	8	10	4	6			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:41749923T>A	uc001zny.2	+	4	523	c.511T>A	c.(511-513)TCT>ACT	p.S171T		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	171	Ser-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		AGATTCAGACTCTTCCTCAGA	0.478													0	0	0	0.000319135	0	41	153										A	41749923	T	A	41749923	3	1	52	1	0	0	0	0	1	0	0	0	13721	1551	54	5	525	5	RTF1	15	41749923	Missense_Mutation	SNP	T	TCGA-DK-A2I1-01A-11D-A17V-08	8557667	41749923	60781469	196	14539										
CDAN1	146059	broad.mit.edu	37	chr15	43026452	43026452	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cactgccctcataggcagctCgaaggcggccttgcagagct	12	14	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:43026452C>T	uc001zql.2	-	7	1346	c.1229G>A	c.(1228-1230)CGA>CAA	p.R410Q	CDAN1_uc001zqk.2_5'UTR|CDAN1_uc010bcx.1_Intron	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	410						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		ATAGGCAGCTCGAAGGCGGCC	0.557													0	0	0	0.000175454	0	20	57										T	43026452	C	T	43026452	3	4	52	1	0	0	0	0	1	0	0	0	3054	884	31	1	2542	1	CDAN1	15	43026452	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1276529	43026452	59504940	197	14540										
UBR1	197131	broad.mit.edu	37	chr15	43360220	43360220	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgaaaaggacacaatagtatCtttcatttttctccctgtta	5	8	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:43360220C>G	uc001zqq.2	-	6	740	c.674G>C	c.(673-675)AGA>ACA	p.R225T	UBR1_uc010udk.1_Missense_Mutation_p.R225T	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	225					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ACAATAGTATCTTTCATTTTT	0.289													0	0	0	0.000184323	0	23	93										G	43360220	C	G	43360220	3	3	52	1	0	0	0	0	1	0	0	0	16898	913	32	1	4743	1	UBR1	15	43360220	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	333768	43360220	59171172	198	14541										
DYX1C1	161582	broad.mit.edu	37	chr15	55790518	55790518	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccagctgtaatcgctaacctGaagaggcattccggtagcaa	10	11	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:55790518G>A	uc002adc.2	-	2	378	c.10C>T	c.(10-12)CAG>TAG	p.Q4*	CCPG1_uc002acy.2_5'UTR|DYX1C1_uc010ugh.1_RNA|DYX1C1_uc010ugi.1_RNA|DYX1C1_uc002adb.2_Nonsense_Mutation_p.Q4*|DYX1C1_uc002add.2_Nonsense_Mutation_p.Q4*	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1 isoform a	4	CS.				neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			skin(1)	1				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		TCGCTAACCTGAAGAGGCATT	0.592													0	0	0	0.000602214	0	5	22										A	55790518	G	A	55790518	4	1	52	1	0	0	0	0	0	1	0	0	4862	1299	45	1	1391	1	DYX1C1	15	55790518	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	12430298	55790518	46740874	199	14542										
CCPG1	9236	broad.mit.edu	37	chr15	55790547	55790547	+	Translation_Start_Site	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttccggtagcaacgggagcgGatagcgcggctggttgcttc	16	10	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:55790547G>C	uc002acy.2	-	1	236	c.-1181C>G	c.(-1183--1179)ATCCG>ATGCG		DYX1C1_uc010ugh.1_RNA|DYX1C1_uc010ugi.1_RNA|DYX1C1_uc002adb.2_Translation_Start_Site|DYX1C1_uc002adc.2_Translation_Start_Site|DYX1C1_uc002add.2_Translation_Start_Site	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2						cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		AACGGGAGCGGATAGCGCGGC	0.632													0	0	0	6.4e-05	0	3	20										C	55790547	G	C	55790547	1	2	52	1	0	0	0	0	0	0	0	0	2938	1189	41	1		1	CCPG1	15	55790547	Translation_Start_Site	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	29	55790547	46740845	200	14543										
ADAM10	102	broad.mit.edu	37	chr15	58919991	58919991	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgttgttaagtttgtccccaGatgttgctcttgcatacatg	9	8	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:58919991G>A	uc002afd.1	-	10	1712	c.1268C>T	c.(1267-1269)TCT>TTT	p.S423F	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.S122F|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	423	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		TTTGTCCCCAGATGTTGCTCT	0.353													0	0	0	0.000295444	0	22	66										A	58919991	G	A	58919991	3	1	52	1	0	0	0	0	1	0	0	0	234	942	33	1	1006	1	ADAM10	15	58919991	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3129444	58919991	43611401	201	14544										
PIF1	80119	broad.mit.edu	37	chr15	65114716	65114716	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gatgctctggcctttcaggaCggccctcagcacagcagcct	11	15	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:65114716C>T	uc002ant.2	-	3	718	c.652G>A	c.(652-654)GTC>ATC	p.V218I	PIF1_uc002anr.2_5'Flank|PIF1_uc002ans.2_5'Flank|PIF1_uc010uiq.1_Missense_Mutation_p.V218I|PIF1_uc002anu.2_Missense_Mutation_p.V218I	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	218	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0						CCTTTCAGGACGGCCCTCAGC	0.622													0	0	0	0.00010058	0	11	30										T	65114716	C	T	65114716	3	4	52	1	0	0	0	0	1	0	0	0	11883	536	19	2	1317	2	PIF1	15	65114716	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6194725	65114716	37416676	202	14545										
LCTL	197021	broad.mit.edu	37	chr15	66845521	66845521	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccaagaaatcggatgtgcctTtaatgtagctcttctcctgg	9	10	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:66845521T>G	uc002aqc.2	-	9	1130	c.998A>C	c.(997-999)AAA>ACA	p.K333T	LCTL_uc002aqd.3_Missense_Mutation_p.K160T|LCTL_uc010bhw.2_Missense_Mutation_p.K31T	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	333	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						GGATGTGCCTTTAATGTAGCT	0.488													0	0	0	0.000147903	0	51	200										G	66845521	T	G	66845521	3	3	52	1	0	0	0	0	1	0	0	0	8694	1841	64	5	725	5	LCTL	15	66845521	Missense_Mutation	SNP	T	TCGA-DK-A2I1-01A-11D-A17V-08	1730805	66845521	35685871	203	14546										
LINGO1	84894	broad.mit.edu	37	chr15	77907318	77907318	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctggatctcctgcagccggaGcagctcatgcaacatggagc	12	13	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:77907318G>T	uc002bct.1	-	2	983	c.931C>A	c.(931-933)CTC>ATC	p.L311I	LINGO1_uc002bcu.1_Missense_Mutation_p.L305I	NM_032808	NP_116197	Q96FE5	LIGO1_HUMAN	leucine-rich repeat neuronal 6A	311	Extracellular (Potential).				negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)|lung(1)	2						TGCAGCCGGAGCAGCTCATGC	0.627													1	0	0.000219431	0.000219431	0.00335712	15	69										T	77907318	G	T	77907318	3	4	52	1	0	0	0	0	1	0	0	0	8814	971	34	4	935	4	LINGO1	15	77907318	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	11061797	77907318	24624074	204	14547										
C15orf42	90381	broad.mit.edu	37	chr15	90169198	90169198	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cctcccagctgtgccgtgcgGagctgcctctctgccagtgc	12	17	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr15:90169198G>C	uc002boe.2	+	21	5508	c.5508G>C	c.(5506-5508)CGG>CGC	p.R1836R	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1836					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTGCCGTGCGGAGCTGCCTCT	0.617													0	0	0	0.000422831	0	16	32										C	90169198	G	C	90169198	2	2	52	1	0	0	0	0	0	0	0	1	1796	1161	41	1		1	C15orf42	15	90169198	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	12261880	90169198	12362194	205	14548										
MLST8	64223	broad.mit.edu	37	chr16	2256193	2256193	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccacagcggcatctgcacccGgacggtgcagcaccaggact	12	16	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:2256193G>A	uc002coz.2	+	2	226	c.107G>A	c.(106-108)CGG>CAG	p.R36Q	MLST8_uc002coy.2_Missense_Mutation_p.R36Q|MLST8_uc002cpa.2_5'UTR|MLST8_uc002cpb.2_Missense_Mutation_p.R36Q|MLST8_uc010uvx.1_5'UTR|MLST8_uc002cpc.2_Missense_Mutation_p.R36Q|MLST8_uc002cpd.2_5'UTR|MLST8_uc002cpe.2_Missense_Mutation_p.R36Q|MLST8_uc010uvy.1_Missense_Mutation_p.R36Q|MLST8_uc002cpg.2_Missense_Mutation_p.R55Q|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Missense_Mutation_p.R36Q	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	36	WD 1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						ATCTGCACCCGGACGGTGCAG	0.701													0	0	0	0.000422831	0	16	46										A	2256193	G	A	2256193	3	1	52	1	0	0	0	0	1	0	0	0	9634	1116	39	2	109	2	MLST8	16	2256193	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		2256193	88098560	206	14549										
CCNF	899	broad.mit.edu	37	chr16	2485829	2485829	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgctgaaaaggggaatttcGaagctgctgtgaagctgggc	15	7	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:2485829G>A	uc002cqd.1	+	4	389	c.301G>A	c.(301-303)GAA>AAA	p.E101K	CCNF_uc002cqe.1_5'UTR	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	101					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GGGGAATTTCGAAGCTGCTGT	0.458													0	0	0	0.000308642	0	16	47										A	2485829	G	A	2485829	3	1	52	1	0	0	0	0	1	0	0	0	2922	1059	37	1	315	1	CCNF	16	2485829	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	229636	2485829	87868924	207	14550										
CREBBP	1387	broad.mit.edu	37	chr16	3828129	3828129	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	acgcgacctccgtttttcttCtagttctttttgtatcttgt	6	10	4	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:3828129C>G	uc002cvv.2	-	10	2200	c.1996G>C	c.(1996-1998)GAA>CAA	p.E666Q	CREBBP_uc002cvw.2_Missense_Mutation_p.E628Q	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	666	KIX.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CGTTTTTCTTCTAGTTCTTTT	0.403			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.000147903	0	104	64										G	3828129	C	G	3828129	3	3	52	1	0	0	0	0	1	0	0	0	3861	922	32	1	5420	1	CREBBP	16	3828129	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1342300	3828129	86526624	208	14551										
KIAA0430	9665	broad.mit.edu	37	chr16	15727580	15727580	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	taaaaaacttctcacggattCtttgcacaacagcagttgct	6	10	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:15727580C>G	uc002ddr.2	-	5	1320	c.1127G>C	c.(1126-1128)AGA>ACA	p.R376T	KIAA0430_uc002ddq.2_Missense_Mutation_p.R375T|KIAA0430_uc010uzv.1_Missense_Mutation_p.R372T|KIAA0430_uc010uzw.1_Missense_Mutation_p.R375T	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	375						peroxisome	nucleotide binding|RNA binding				0						CTCACGGATTCTTTGCACAAC	0.428													0	0	0	0.000147903	0	50	196										G	15727580	C	G	15727580	3	3	52	1	0	0	0	0	1	0	0	0	8177	913	32	1	4196	1	KIAA0430	16	15727580	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	11899451	15727580	74627173	209	14552										
GGA2	23062	broad.mit.edu	37	chr16	23491968	23491968	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agaagctttcaaacatacctCtggagacagggatgtctccc	9	11	3	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:23491968C>G	uc002dlq.2	-	10	1080	c.1004G>C	c.(1003-1005)AGA>ACA	p.R335T	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	335	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		AAACATACCTCTGGAGACAGG	0.498													0	0	0	0.000147802	0	29	24										G	23491968	C	G	23491968	3	3	52	1	0	0	0	0	1	0	0	0	6353	913	32	1	869	1	GGA2	16	23491968	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	7764388	23491968	66862785	210	14553										
ITGAL	3683	broad.mit.edu	37	chr16	30510399	30510399	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gccttctgccctgcagctccCggcccgtggtggatatggtc	13	15	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:30510399C>T	uc002dyi.3	+	16	2013	c.1837C>T	c.(1837-1839)CGG>TGG	p.R613W	ITGAL_uc002dyj.3_Missense_Mutation_p.R530W|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	613	FG-GAP 7.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CTGCAGCTCCCGGCCCGTGGT	0.572													0	0	0	8.12818e-05	0	7	25										T	30510399	C	T	30510399	3	4	52	1	0	0	0	0	1	0	0	0	7886	643	23	2	1899	2	ITGAL	16	30510399	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	7018431	30510399	59844354	211	14554										
CNOT1	23019	broad.mit.edu	37	chr16	58572154	58572154	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	attatatttatattcatctcGacattcaattaggcacctag	4	8	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:58572154G>A	uc002env.2	-	37	5445	c.5152C>T	c.(5152-5154)CGA>TGA	p.R1718*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.R1713*|CNOT1_uc010vik.1_Nonsense_Mutation_p.R675*	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1718					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TATTCATCTCGACATTCAATT	0.373													0	0	0	0.000422831	0	16	45										A	58572154	G	A	58572154	4	1	52	1	0	0	0	0	0	1	0	0	3617	1066	37	1	2030	1	CNOT1	16	58572154	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	28061755	58572154	31782599	212	14555										
HSD17B2	3294	broad.mit.edu	37	chr16	82131777	82131777	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gactacggccaggactacatCttagcacagcggaatttcct	9	12	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr16:82131777C>T	uc002fgv.2	+	5	1072	c.900C>T	c.(898-900)ATC>ATT	p.I300I		NM_002153	NP_002144	P37059	DHB2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 2	300					response to retinoic acid|steroid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|binding|estradiol 17-beta-dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2					NADH(DB00157)	AGGACTACATCTTAGCACAGC	0.542													0	0	0	0.000491102	0	30	40										T	82131777	C	T	82131777	2	4	52	1	0	0	0	0	0	0	0	1	7384	903	32	1		1	HSD17B2	16	82131777	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	23559623	82131777	8222976	213	14556										
FAM57A	79850	broad.mit.edu	37	chr17	643751	643751	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttcgtcatccgcagaggctcCggggagaccttggggacttc	14	12	1	2	rs144403190		TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:643751C>T	uc002frp.2	+	4	456	c.415C>T	c.(415-417)CGG>TGG	p.R139W	FAM57A_uc002frq.2_Intron|FAM57A_uc002frr.2_Missense_Mutation_p.R49W	NM_024792	NP_079068	Q8TBR7	FA57A_HUMAN	family with sequence similarity 57, member A	139	TLC.					integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0217)		GCAGAGGCTCCGGGGAGACCT	0.517													0	0	0	0.000602214	0	5	95										T	643751	C	T	643751	3	4	52	1	0	0	0	0	1	0	0	0	5588	643	23	2	429	2	FAM57A	17	643751	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		643751	80551459	214	14557										
USP6	9098	broad.mit.edu	37	chr17	5041030	5041030	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgccaataaccagcattgctCttaaggttcagcagagtaag	9	9	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:5041030C>G	uc002gau.1	+	20	3140	c.910C>G	c.(910-912)CTT>GTT	p.L304V	USP6_uc002gav.1_Missense_Mutation_p.L304V|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	304					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						CAGCATTGCTCTTAAGGTTCA	0.587			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								0	0	0	0.000147903	0	58	41										G	5041030	C	G	5041030	3	3	52	1	0	0	0	0	1	0	0	0	17083	913	32	1	952	1	USP6	17	5041030	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	4397279	5041030	76154180	215	14558										
TMEM102	284114	broad.mit.edu	37	chr17	7339584	7339584	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgcttcgtggtgggattcgcGagggctccctggatctgggg	18	9	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:7339584G>C	uc002ggx.1	+	3	559	c.286G>C	c.(286-288)GAG>CAG	p.E96Q	FGF11_uc010vtw.1_Intron|TMEM102_uc002ggy.1_Missense_Mutation_p.E96Q	NM_178518	NP_848613	Q8N9M5	TM102_HUMAN	transmembrane protein 102	96	Extracellular (Potential).				regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding				0		Prostate(122;0.173)				TGGGATTCGCGAGGGCTCCCT	0.617													0	0	0	9.7654e-05	0	18	15										C	7339584	G	C	7339584	3	2	52	1	0	0	0	0	1	0	0	0	16014	1059	37	1	292	1	TMEM102	17	7339584	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2298554	7339584	73855626	216	14559										
MYH10	4628	broad.mit.edu	37	chr17	8396109	8396109	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cccacctggtcaaacttcttCtgcttcttctccaagttgga	6	14	5	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:8396109C>T	uc002gll.2	-	31	4446	c.4350G>A	c.(4348-4350)CAG>CAA	p.Q1450Q	MYH10_uc002glm.2_Silent_p.Q1481Q|MYH10_uc010cnx.2_Silent_p.Q1459Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1450	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CAAACTTCTTCTGCTTCTTCT	0.517													0	0	0	8.12818e-05	0	7	27										T	8396109	C	T	8396109	2	4	52	1	0	0	0	0	0	0	0	1	10030	912	32	1		1	MYH10	17	8396109	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1056525	8396109	72799101	217	14560										
MYH3	4621	broad.mit.edu	37	chr17	10558329	10558330	+	Missense_Mutation	DNP	CG	CG	AT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcctctccttttctgacttcCggaggaaaggagcagctatg							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:10558329_10558330CG>AT	uc002gmq.1	-	2	129_130	c.52_53CG>AT	c.(52-54)CGG>ATG	p.R18M		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	18	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCTGACTTCCGGAGGAAAGGA	0.53													0	0	0	6.4e-05	0	6	107										AT	10558330	CG	AT	10558329	3	1	52	1	0	0	0	0	1	0	0	0	10036	652	23	4	5925	4	MYH3	17	10558329	Missense_Mutation	DNP	CG	TCGA-DK-A2I1-01A-11D-A17V-08	2162220	10558329	70636881	218	14561										
TMEM97	27346	broad.mit.edu	37	chr17	26646275	26646275	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	accgacagactatgggggctCcggcaaccaggcgctgcgtg	15	13	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:26646275C>G	uc002hat.2	+	1	155	c.10C>G	c.(10-12)CCG>GCG	p.P4A		NM_014573	NP_055388	Q5BJF2	TMM97_HUMAN	transmembrane protein 97	4	Cytoplasmic (Potential).				cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding				0	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TATGGGGGCTCCGGCAACCAG	0.677													0	0	0	8.12818e-05	0	6	25										G	26646275	C	G	26646275	3	3	52	1	0	0	0	0	1	0	0	0	16221	855	30	1	12	1	TMEM97	17	26646275	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	16087946	26646275	54548935	219	14562										
TMEM97	27346	broad.mit.edu	37	chr17	26646322	26646322	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgctgggcctctacttcctCagccacatccccatcaccct	5	20	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:26646322C>T	uc002hat.2	+	1	202	c.57C>T	c.(55-57)CTC>CTT	p.L19L		NM_014573	NP_055388	Q5BJF2	TMM97_HUMAN	transmembrane protein 97	19	Helical; (Potential).				cholesterol homeostasis|regulation of cell growth	integral to membrane|lysosome|nuclear membrane|plasma membrane|rough endoplasmic reticulum	protein binding				0	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TCTACTTCCTCAGCCACATCC	0.672													0	0	0	6.40141e-05	0	10	19										T	26646322	C	T	26646322	2	4	52	1	0	0	0	0	0	0	0	1	16221	813	29	1		1	TMEM97	17	26646322	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	47	26646322	54548888	220	14563										
SEBOX	645832	broad.mit.edu	37	chr17	26691931	26691931	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccagtagctgccctttgctGaaggtggtccgctttctccg	11	13	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:26691931G>A	uc010wai.1	-	2	170	c.156C>T	c.(154-156)TTC>TTT	p.F52F	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_Silent_p.F51F|SARM1_uc010waj.1_Intron	NM_001080837	NP_001074306	Q9HB31	SEBOX_HUMAN	SEBOX homeobox isoform 1	52	Homeobox.				cell differentiation|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GCCCTTTGCTGAAGGTGGTCC	0.637													0	0	0	0.000157383	0	8	16										A	26691931	G	A	26691931	2	1	52	1	0	0	0	0	0	0	0	1	13977	1281	45	1		1	SEBOX	17	26691931	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	45609	26691931	54503279	221	14564										
LIG3	3980	broad.mit.edu	37	chr17	33310224	33310224	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gggaagccatctaagatcacGtgccacctaccttgttttct	8	12	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:33310224G>A	uc002hik.1	+	2	308	c.200G>A	c.(199-201)CGT>CAT	p.R67H	LIG3_uc002hii.2_Missense_Mutation_p.R67H|LIG3_uc002hij.2_Missense_Mutation_p.R67H|LIG3_uc010cth.1_Missense_Mutation_p.R76H	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	67					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	CTAAGATCACGTGCCACCTAC	0.517								Other_BER_factors					0	0	0	0.000228196	0	38	77										A	33310224	G	A	33310224	3	1	52	1	0	0	0	0	1	0	0	0	8782	1145	40	2	202	2	LIG3	17	33310224	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	6618293	33310224	47884986	222	14565										
SLFN13	146857	broad.mit.edu	37	chr17	33768156	33768156	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcttggatactgtgctgagaGagggggaaggccactgtgac	16	7	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:33768156G>A	uc002hjk.1	-	4	2482	c.2152C>T	c.(2152-2154)CTC>TTC	p.L718F	SLFN13_uc010wch.1_Missense_Mutation_p.L718F|SLFN13_uc002hjl.2_Missense_Mutation_p.L718F|SLFN13_uc010ctt.2_Missense_Mutation_p.L400F|SLFN13_uc002hjm.2_Missense_Mutation_p.L387F	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	718						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGTGCTGAGAGAGGGGGAAGG	0.438													0	0	0	0.000339439	0	33	207										A	33768156	G	A	33768156	3	1	52	1	0	0	0	0	1	0	0	0	14736	942	33	1	545	1	SLFN13	17	33768156	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	457932	33768156	47427054	223	14566										
PEX12	5193	broad.mit.edu	37	chr17	33902981	33902981	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cacagtgggcacacagtcttCattttgggtaagaggggaga	14	7	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:33902981C>T	uc002hjp.2	-	3	1516	c.900G>A	c.(898-900)ATG>ATA	p.M300I		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	300	Cytoplasmic (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACACAGTCTTCATTTTGGGTA	0.458													0	0	0	0.000375601	0	24	98										T	33902981	C	T	33902981	3	4	52	1	0	0	0	0	1	0	0	0	11740	826	29	1	183	1	PEX12	17	33902981	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	134825	33902981	47292229	224	14567										
MRM1	79922	broad.mit.edu	37	chr17	34964825	34964825	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cagggctgtcttcaggcccaGagaaagagaggcaaaatgag	14	8	2	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:34964825G>C	uc002hne.2	+	5	1251	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q	MRM1_uc002hnf.2_Missense_Mutation_p.E151Q	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	346					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TTCAGGCCCAGAGAAAGAGAG	0.622													0	0	0	9.22233e-05	0	24	62										C	34964825	G	C	34964825	3	2	52	1	0	0	0	0	1	0	0	0	9771	943	33	1	1054	1	MRM1	17	34964825	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1061844	34964825	46230385	225	14568										
CDK12	51755	broad.mit.edu	37	chr17	37627781	37627781	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctcttccacagcaaccacctCtgcctccttctcagccagca	4	20	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:37627781C>T	uc010cvv.2	+	2	2282	c.1696C>T	c.(1696-1698)CTG>TTG	p.L566L	CDK12_uc010wef.1_Silent_p.L565L|CDK12_uc002hrw.3_Silent_p.L566L	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	566					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GCAACCACCTCTGCCTCCTTC	0.547										TCGA Ovarian(9;0.13)			0	0	0	0.000147903	0	71	259										T	37627781	C	T	37627781	2	4	52	1	0	0	0	0	0	0	0	1	3128	912	32	1		1	CDK12	17	37627781	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2662956	37627781	43567429	226	14569										
DBF4B	80174	broad.mit.edu	37	chr17	42828543	42828543	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gatcatgaccttggacatctCtgccaggccaaaccccaagg	9	14	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:42828543C>T	uc002ihf.2	+	14	1983	c.1770C>T	c.(1768-1770)CTC>CTT	p.L590L	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	590					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				TTGGACATCTCTGCCAGGCCA	0.552													0	0	0	0.000147903	0	46	42										T	42828543	C	T	42828543	2	4	52	1	0	0	0	0	0	0	0	1	4249	900	32	1		1	DBF4B	17	42828543	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	5200762	42828543	38366667	227	14570										
ADAM11	4185	broad.mit.edu	37	chr17	42850284	42850284	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tatgtggagctaattgtgatCaacgaccaccagctggtgag	12	8	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:42850284C>T	uc002ihh.2	+	9	738	c.738C>T	c.(736-738)ATC>ATT	p.I246I	ADAM11_uc010wjd.1_Silent_p.I46I	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	246	Extracellular (Potential).|Peptidase M12B.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				TAATTGTGATCAACGACCACC	0.612													0	0	0	0.000274275	0	9	29										T	42850284	C	T	42850284	2	4	52	1	0	0	0	0	0	0	0	1	235	816	29	1		1	ADAM11	17	42850284	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	21741	42850284	38344926	228	14571										
EFTUD2	9343	broad.mit.edu	37	chr17	42942371	42942371	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttcagcttcagctcctccttCgtcaggtggatgccaagctc	9	14	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:42942371C>T	uc002ihn.2	-	14	1473	c.1212G>A	c.(1210-1212)ACG>ACA	p.T404T	EFTUD2_uc010wje.1_Silent_p.T369T|EFTUD2_uc010wjf.1_Silent_p.T394T	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	404						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				GCTCCTCCTTCGTCAGGTGGA	0.547											OREG0024466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000566183	0	18	83										T	42942371	C	T	42942371	2	4	52	1	0	0	0	0	0	0	0	1	4961	871	31	1		1	EFTUD2	17	42942371	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	92087	42942371	38252839	229	14572										
MKS1	54903	broad.mit.edu	37	chr17	56288082	56288082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	catactcatagccttgggctGaaactacgagagaaaacagg	10	9	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:56288082G>A	uc002ivr.1	-	11	1037	c.962C>T	c.(961-963)TCA>TTA	p.S321L	MKS1_uc010wnq.1_Missense_Mutation_p.S118L|MKS1_uc002ivs.1_Missense_Mutation_p.S321L	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	321	B9.				cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						GCCTTGGGCTGAAACTACGAG	0.438													0	0	0	0.000279167	0	29	59										A	56288082	G	A	56288082	3	1	52	1	0	0	0	0	1	0	0	0	9609	1294	45	1	749	1	MKS1	17	56288082	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	13345711	56288082	24907128	230	14573										
MED13	9969	broad.mit.edu	37	chr17	60069976	60069976	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgttacactagatgtcccatCttctacctgcaaacaaatat	4	11	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:60069976C>A	uc002izo.2	-	11	2265	c.2188G>T	c.(2188-2190)GAT>TAT	p.D730Y		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	730					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GATGTCCCATCTTCTACCTGC	0.239													1	0	3.09899e-07	0.000274275	4.90421e-06	9	52										A	60069976	C	A	60069976	3	1	52	1	0	0	0	0	1	0	0	0	9430	913	32	3	4416	3	MED13	17	60069976	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3781894	60069976	21125234	231	14574										
DDX5	1655	broad.mit.edu	37	chr17	62496163	62496163	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aacattacttccgtattgctGagtgctatcataaccattct	5	10	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:62496163G>A	uc002jek.2	-	13	1970	c.1723C>T	c.(1723-1725)CAG>TAG	p.Q575*	POLG2_uc002jei.2_5'Flank|POLG2_uc010deg.1_5'Flank|DDX5_uc010deh.2_Nonsense_Mutation_p.Q575*|DDX5_uc002jej.2_Nonsense_Mutation_p.Q470*|DDX5_uc010wqa.1_Nonsense_Mutation_p.Q496*	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	575					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CCGTATTGCTGAGTGCTATCA	0.418			T	ETV4	prostate								0	0	0	0.00058488	0	36	51										A	62496163	G	A	62496163	4	1	52	1	0	0	0	0	0	1	0	0	4367	1299	45	1	125	1	DDX5	17	62496163	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2426187	62496163	18699047	232	14575										
SLC25A19	60386	broad.mit.edu	37	chr17	73282772	73282772	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcgcccgagtaacaagtccaGacacagacccagccactgcc	9	17	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:73282772G>C	uc002jns.3	-	1	984	c.74C>G	c.(73-75)TCT>TGT	p.S25C	SLC25A19_uc010dge.2_Missense_Mutation_p.S25C|SLC25A19_uc002jnv.3_Missense_Mutation_p.S25C|SLC25A19_uc002jnu.3_Missense_Mutation_p.S25C|SLC25A19_uc002jnw.3_Missense_Mutation_p.S25C|SLC25A19_uc002jnt.3_Missense_Mutation_p.S25C	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	25	Helical; Name=1; (Potential).|Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			AACAAGTCCAGACACAGACCC	0.537													0	0	0	0.00024832	0	4	56										C	73282772	G	C	73282772	3	2	52	1	0	0	0	0	1	0	0	0	14481	942	33	1	912	1	SLC25A19	17	73282772	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	10786609	73282772	7912438	233	14576										
RECQL5	9400	broad.mit.edu	37	chr17	73658835	73658836	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tcaggacgaaagtcatgcccCcattgggaaacacaatgagc							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr17:73658835_73658836CC>AA	uc010dgl.2	-	4	650_651	c.494_495GG>TT	c.(493-495)TGG>TTT	p.W165F	RECQL5_uc010dgk.2_Missense_Mutation_p.W138F|RECQL5_uc002jpb.1_Missense_Mutation_p.W165F|RECQL5_uc002joz.3_Missense_Mutation_p.W165F|RECQL5_uc002jpa.3_Missense_Mutation_p.W165F	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	165	Helicase ATP-binding.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGTCATGCCCCCATTGGGAAAC	0.609								Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	6.4e-05	0	10	180										AA	73658836	CC	AA	73658835	3	1	52	1	0	0	0	0	1	0	0	0	13203	624	22	4	2635	4	RECQL5	17	73658835	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	376063	73658835	7536375	234	14577										
MYOM1	8736	broad.mit.edu	37	chr18	3129298	3129298	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagccgctttctgtggtggcGgggtaagctcttcctgaact	14	10	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr18:3129298G>T	uc002klp.2	-	18	3060	c.2726C>A	c.(2725-2727)CCG>CAG	p.P909Q	MYOM1_uc002klq.2_Intron	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	909						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CTGTGGTGGCGGGGTAAGCTC	0.493											OREG0024838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.000602214	0.000602214	0.00908751	5	75										T	3129298	G	T	3129298	3	4	52	1	0	0	0	0	1	0	0	0	10091	1116	39	4	2415	4	MYOM1	18	3129298	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		3129298	74947950	235	14578										
DTNA	1837	broad.mit.edu	37	chr18	32438313	32438313	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aagcttctcagcccacgccaGagaaggcacagcaaaacccc	8	16	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr18:32438313G>C	uc010dmn.1	+	15	1517	c.1516G>C	c.(1516-1518)GAG>CAG	p.E506Q	DTNA_uc010xbx.1_Missense_Mutation_p.E256Q|DTNA_uc002kxv.3_Missense_Mutation_p.E449Q|DTNA_uc002kxw.2_Missense_Mutation_p.E449Q|DTNA_uc010dmj.2_Missense_Mutation_p.E446Q|DTNA_uc002kxz.2_Missense_Mutation_p.E446Q|DTNA_uc002kxy.2_Missense_Mutation_p.E446Q|DTNA_uc010dml.2_Missense_Mutation_p.E446Q|DTNA_uc002kyb.3_Missense_Mutation_p.E503Q|DTNA_uc010dmm.2_Missense_Mutation_p.E506Q|DTNA_uc010xby.1_Missense_Mutation_p.E196Q|DTNA_uc010dmo.2_Missense_Mutation_p.E128Q|DTNA_uc002kyd.3_Missense_Mutation_p.E128Q|DTNA_uc010xbz.1_Missense_Mutation_p.E215Q|DTNA_uc010xca.1_Missense_Mutation_p.E158Q|DTNA_uc002kye.2_Missense_Mutation_p.E154Q	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	506	Potential.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GCCCACGCCAGAGAAGGCACA	0.512													0	0	0	0.000117367	0	25	22										C	32438313	G	C	32438313	3	2	52	1	0	0	0	0	1	0	0	0	4788	943	33	1	1609	1	DTNA	18	32438313	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	29309015	32438313	45638935	236	14579										
CD226	10666	broad.mit.edu	37	chr18	67614163	67614163	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	accatgccatgagtagggctGaaaatggctatggaatcctg	12	8	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr18:67614163G>T	uc010dqo.2	-	2	636	c.189C>A	c.(187-189)TTC>TTA	p.F63L	CD226_uc002lkm.3_Missense_Mutation_p.F63L	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	63	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				GAGTAGGGCTGAAAATGGCTA	0.453													1	0	1.75199e-13	0.000184323	2.8293e-12	28	22										T	67614163	G	T	67614163	3	4	52	1	0	0	0	0	1	0	0	0	2986	1281	45	3	841	3	CD226	18	67614163	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	35175850	67614163	10463085	237	14580										
SOCS6	9306	broad.mit.edu	37	chr18	67992477	67992477	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	caggagcaagccaattcactGaagagctcggcttctcataa	9	11	2	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr18:67992477G>A	uc002lkr.1	+	2	889	c.573G>A	c.(571-573)CTG>CTA	p.L191L	SOCS6_uc010dqq.2_Silent_p.L191L	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	191					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CCAATTCACTGAAGAGCTCGG	0.522													0	0	0	9.22233e-05	0	25	65										A	67992477	G	A	67992477	2	1	52	1	0	0	0	0	0	0	0	1	14918	1277	45	1		1	SOCS6	18	67992477	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	378314	67992477	10084771	238	14581										
GZMM	3004	broad.mit.edu	37	chr19	549010	549010	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggcagcagggactcggtgcaGcatggccggctgggggctga	20	10	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:549010G>A	uc002low.1	+	4	482	c.437G>A	c.(436-438)AGC>AAC	p.S146N		NM_005317	NP_005308	P51124	GRAM_HUMAN	granzyme M precursor	146	Peptidase S1.				apoptosis|cytolysis|innate immune response|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCGGTGCAGCATGGCCGGC	0.682													0	0	0	3.59834e-05	0	6	19										A	549010	G	A	549010	3	1	52	1	0	0	0	0	1	0	0	0	6919	971	34	2	451	2	GZMM	19	549010	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08		549010	58579973	239	14582										
STAP2	55620	broad.mit.edu	37	chr19	4333712	4333712	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttgaacttgatctcctgatcCcggagaatcaggctgaagtg	11	9	2	5			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:4333712C>A	uc002mab.2	-	3	373	c.276G>T	c.(274-276)CGG>CGT	p.R92R	STAP2_uc002mac.2_Silent_p.R92R|STAP2_uc002mad.2_5'UTR	NM_001013841	NP_001013863	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	92	PH.					cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCCTGATCCCGGAGAATCA	0.547													1	0	3.59834e-05	3.59834e-05	0.000558247	6	41										A	4333712	C	A	4333712	2	1	52	1	0	0	0	0	0	0	0	1	15252	610	22	4		4	STAP2	19	4333712	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3784702	4333712	54795271	240	14583										
PRR22	163154	broad.mit.edu	37	chr19	5784138	5784138	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccaagcctgggggcctgtttGggagatgccacaagaacctt	13	11	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:5784138G>C	uc002mdb.1	-	1	473	c.114C>G	c.(112-114)CCC>CCG	p.P38P	PRR22_uc010xiv.1_Intron	NM_153359	NP_699190	Q8IZ63	PRR22_HUMAN	proline rich 22 isoform 2	38											0						GGGCCTGTTTGGGAGATGCCA	0.637													0	0	0	0.000566183	0	16	137										C	5784138	G	C	5784138	2	2	52	1	0	0	0	0	0	0	0	1	12593	1363	47	4		4	PRR22	19	5784138	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1450426	5784138	53344845	241	14584										
MUC16	94025	broad.mit.edu	37	chr19	9059205	9059205	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atgacacatcctcaggacctCtgctcataggagttgtcacc	8	13	4	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:9059205C>T	uc002mkp.2	-	3	28445	c.28241G>A	c.(28240-28242)AGA>AAA	p.R9414K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9416	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCAGGACCTCTGCTCATAGG	0.512													0	0	0	0.000147903	0	47	100										T	9059205	C	T	9059205	3	4	52	1	0	0	0	0	1	0	0	0	9973	913	32	1	15610	1	MUC16	19	9059205	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3275067	9059205	50069778	242	14585										
ZNF791	163049	broad.mit.edu	37	chr19	12738664	12738664	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagtgtactatctgtggaaaAgccttcatgcgtctctcatc	9	10	4	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:12738664A>G	uc002mua.2	+	4	483	c.321A>G	c.(319-321)AAA>AAG	p.K107K	ZNF791_uc010xml.1_Silent_p.K75K|ZNF791_uc010dyu.1_5'UTR|ZNF791_uc010xmm.1_5'UTR	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	107	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCTGTGGAAAAGCCTTCATGC	0.433													0	0	0	0.00024832	0	4	231										G	12738664	A	G	12738664	2	3	52	1	0	0	0	0	0	0	0	1	18160	69	3	5		5	ZNF791	19	12738664	Silent	SNP	A	TCGA-DK-A2I1-01A-11D-A17V-08	3679459	12738664	46390319	243	14586										
ZSWIM4	65249	broad.mit.edu	37	chr19	13919937	13919937	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggggcgcgcatgctgattctCatgaccgagcagttcctgca	13	12	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:13919937C>G	uc002mxh.1	+	5	1104	c.915C>G	c.(913-915)CTC>CTG	p.L305L	ZSWIM4_uc010xng.1_Silent_p.L111L	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	305							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TGCTGATTCTCATGACCGAGC	0.697													0	0	0	0.000308642	0	15	42										G	13919937	C	G	13919937	2	3	52	1	0	0	0	0	0	0	0	1	18240	813	29	1		1	ZSWIM4	19	13919937	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1181273	13919937	45209046	244	14587										
PGLYRP2	114770	broad.mit.edu	37	chr19	15586931	15586931	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tggagtgttggctccaatatCtgcagtggtgacatctggag	14	7	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:15586931C>A	uc002nbf.3	-	2	683	c.550G>T	c.(550-552)GAT>TAT	p.D184Y	PGLYRP2_uc002nbg.3_Missense_Mutation_p.D184Y	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	184					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						GCTCCAATATCTGCAGTGGTG	0.542													1	0	2.39187e-15	0.000132079	3.88539e-14	21	137										A	15586931	C	A	15586931	3	1	52	1	0	0	0	0	1	0	0	0	11794	913	32	3	1196	3	PGLYRP2	19	15586931	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1666994	15586931	43542052	245	14588			2	56		3	3	434	C		8.298872e-06
PGLYRP2	114770	broad.mit.edu	37	chr19	15587202	15587202	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgtcgggccacctccttggtCaggcctaacagctctgggct	12	14	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:15587202C>G	uc002nbf.3	-	2	412	c.279G>C	c.(277-279)CTG>CTC	p.L93L	PGLYRP2_uc002nbg.3_Silent_p.L93L	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	93					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CCTCCTTGGTCAGGCCTAACA	0.617													0	0	0	0.000274275	0	8	58										G	15587202	C	G	15587202	2	3	52	1	0	0	0	0	0	0	0	1	11794	813	29	1		1	PGLYRP2	19	15587202	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	271	15587202	43541781	246	14589			2	56		3	3	434	C		8.298872e-06
PGLYRP2	114770	broad.mit.edu	37	chr19	15587364	15587364	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtcttggcagctggcactttCtgctccagctcagccagggc	12	14	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:15587364C>T	uc002nbf.3	-	2	250	c.117G>A	c.(115-117)CAG>CAA	p.Q39Q	PGLYRP2_uc002nbg.3_Silent_p.Q39Q	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	39					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CTGGCACTTTCTGCTCCAGCT	0.602													0	0	0	0.000602214	0	4	25										T	15587364	C	T	15587364	2	4	52	1	0	0	0	0	0	0	0	1	11794	912	32	1		1	PGLYRP2	19	15587364	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	162	15587364	43541619	247	14590			2	56		3	3	434	C		8.298872e-06
COMP	1311	broad.mit.edu	37	chr19	18895873	18895873	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gttcacatggaacgtgccctCgaagtccacgccattgaagg	11	12	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:18895873C>G	uc002nke.2	-	16	1783	c.1747G>C	c.(1747-1749)GAG>CAG	p.E583Q	COMP_uc002nkd.2_Missense_Mutation_p.E550Q|COMP_uc010xqj.1_Missense_Mutation_p.E530Q	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	583	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						AACGTGCCCTCGAAGTCCACG	0.582													0	0	0	0.000151284	0	11	72										G	18895873	C	G	18895873	3	3	52	1	0	0	0	0	1	0	0	0	3724	893	31	1	542	1	COMP	19	18895873	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3308509	18895873	40233110	248	14591										
FBL	2091	broad.mit.edu	37	chr19	40329725	40329725	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgtggtgcccgaggcagcccCgaggtagagaaccttagccc	14	14	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:40329725C>T	uc002omn.2	-	5	613	c.499G>A	c.(499-501)GGG>AGG	p.G167R	FBL_uc002omm.1_Missense_Mutation_p.G81R|FBL_uc002omo.2_Missense_Mutation_p.G166R|FBL_uc010egr.2_Missense_Mutation_p.G167R	NM_001436	NP_001427	P22087	FBRL_HUMAN	fibrillarin	167					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			ovary(1)	1	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		GAGGCAGCCCCGAGGTAGAGA	0.602													0	0	0	7.07596e-05	0	19	70										T	40329725	C	T	40329725	3	4	52	1	0	0	0	0	1	0	0	0	5696	652	23	2	486	2	FBL	19	40329725	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	21433852	40329725	18799258	249	14592										
SPTBN4	57731	broad.mit.edu	37	chr19	41025918	41025918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcccgggcctggcactagacGagtggctgccacacctcgaa	13	15	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:41025918G>A	uc002ony.2	+	16	3600	c.3514G>A	c.(3514-3516)GAG>AAG	p.E1172K	SPTBN4_uc002onx.2_Missense_Mutation_p.E1172K|SPTBN4_uc002onz.2_Missense_Mutation_p.E1172K|SPTBN4_uc010egx.2_5'UTR	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1172	Spectrin 9.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCACTAGACGAGTGGCTGCC	0.682													0	0	0	3.86212e-05	0	9	24										A	41025918	G	A	41025918	3	1	52	1	0	0	0	0	1	0	0	0	15120	1059	37	1	3572	1	SPTBN4	19	41025918	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	696193	41025918	18103065	250	14593										
ATP5SL	55101	broad.mit.edu	37	chr19	41944170	41944170	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccctttggagcaagtaatcCctcagagcctccacatcgta	7	14	1	1	rs118187504	byFrequency	TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:41944170C>T	uc002oqw.1	-	2	174	c.168G>A	c.(166-168)AGG>AGA	p.R56R	CYP2F1_uc010xvw.1_Intron|ATP5SL_uc002oqu.1_RNA|ATP5SL_uc002oqv.2_Silent_p.R62R|ATP5SL_uc010xwa.1_Silent_p.R62R|ATP5SL_uc002oqx.1_Silent_p.R56R|ATP5SL_uc002oqy.1_Silent_p.R56R|ATP5SL_uc002oqz.1_Silent_p.R56R|ATP5SL_uc002ora.1_Silent_p.R43R|ATP5SL_uc010xwb.1_Silent_p.R62R	NM_018035	NP_060505	Q9NW81	AT5SL_HUMAN	ATP5S-like	56										large_intestine(1)|breast(1)	2						GCAAGTAATCCCTCAGAGCCT	0.537													0	0	0	0.000147903	0	53	140										T	41944170	C	T	41944170	2	4	52	1	0	0	0	0	0	0	0	1	1164	622	22	2		2	ATP5SL	19	41944170	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	918252	41944170	17184813	251	14594										
CBLC	23624	broad.mit.edu	37	chr19	45296769	45296769	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgccccttctgccgctgcgaGatcaagggctgggaggccgt	15	13	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:45296769G>A	uc002ozs.2	+	8	1239	c.1176G>A	c.(1174-1176)GAG>GAA	p.E392E	CBLC_uc010ejt.2_Silent_p.E346E	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	392					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				GCCGCTGCGAGATCAAGGGCT	0.637			M		AML								0	0	0	0.000442599	0	8	15										A	45296769	G	A	45296769	2	1	52	1	0	0	0	0	0	0	0	1	2702	933	33	1		1	CBLC	19	45296769	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3352599	45296769	13832214	252	14595										
TMEM143	55260	broad.mit.edu	37	chr19	48866581	48866581	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cggagcagctgctccttggaGaagggaatgaagcgctcgcg	16	10	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:48866581G>C	uc002pix.1	-	2	240	c.231C>G	c.(229-231)TTC>TTG	p.F77L	TMEM143_uc002piw.1_RNA|TMEM143_uc002piy.1_Missense_Mutation_p.F77L|TMEM143_uc010xzn.1_Missense_Mutation_p.F77L|TMEM143_uc010elw.1_Missense_Mutation_p.F77L|TMEM143_uc010xzo.1_Intron|TMEM143_uc010xzp.1_Missense_Mutation_p.F77L|TMEM143_uc010xzq.1_Missense_Mutation_p.F77L|SYNGR4_uc002piz.2_5'Flank	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	77						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GCTCCTTGGAGAAGGGAATGA	0.652													0	0	0	0.00024832	0	4	44										C	48866581	G	C	48866581	3	2	52	1	0	0	0	0	1	0	0	0	16054	933	33	1	1176	1	TMEM143	19	48866581	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	3569812	48866581	10262402	253	14596										
PLEKHA4	57664	broad.mit.edu	37	chr19	49362856	49362856	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tgattctgagatgcgcccctCttcccctctgctcacctccg	7	18	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:49362856C>T	uc002pkx.2	-	7	1113	c.562G>A	c.(562-564)GAG>AAG	p.E188K	PLEKHA4_uc002pkw.1_5'Flank|PLEKHA4_uc010eml.2_Missense_Mutation_p.E188K	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	188	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		ATGCGCCCCTCTTCCCCTCTG	0.677													0	0	0	3.59834e-05	0	5	34										T	49362856	C	T	49362856	3	4	52	1	0	0	0	0	1	0	0	0	12058	922	32	1	1833	1	PLEKHA4	19	49362856	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	496275	49362856	9766127	254	14597										
NR1H2	7376	broad.mit.edu	37	chr19	50881040	50881040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cttcttcacccactgtaaagGaggagggtccggagccgtgg	14	11	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:50881040G>A	uc010enw.2	+	4	370	c.94G>A	c.(94-96)GAG>AAG	p.E32K	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.E32K|NR1H2_uc002psa.3_Missense_Mutation_p.E32K	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	32					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CACTGTAAAGGAGGAGGGTCC	0.647													0	0	0	3.86212e-05	0	10	51										A	50881040	G	A	50881040	3	1	52	1	0	0	0	0	1	0	0	0	10617	1175	41	1	100	1	NR1H2	19	50881040	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1518184	50881040	8247943	255	14598										
ZNF611	81856	broad.mit.edu	37	chr19	53209076	53209076	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttctatgtcgagccagctgtGaatgccacgtgaaagctgtg	12	9	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:53209076G>C	uc002pzz.2	-	7	1549	c.1232C>G	c.(1231-1233)TCA>TGA	p.S411*	ZNF611_uc010eqc.2_Nonsense_Mutation_p.S341*|ZNF611_uc010ydo.1_Nonsense_Mutation_p.S341*|ZNF611_uc010ydr.1_Nonsense_Mutation_p.S342*|ZNF611_uc010ydp.1_Nonsense_Mutation_p.S411*|ZNF611_uc010ydq.1_Nonsense_Mutation_p.S411*|ZNF611_uc002qaa.3_Nonsense_Mutation_p.S341*	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	411	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		AGCCAGCTGTGAATGCCACGT	0.403													0	0	0	0.000147903	0	52	82										C	53209076	G	C	53209076	4	2	52	1	0	0	0	0	0	1	0	0	18034	1294	45	1	889	1	ZNF611	19	53209076	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2328036	53209076	5919907	256	14599										
CACNG8	59283	broad.mit.edu	37	chr19	54485522	54485522	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tctacatcgagcgcagccgcGaggcgcactgccagtctcgc	12	16	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr19:54485522G>C	uc002qcs.1	+	4	800	c.694G>C	c.(694-696)GAG>CAG	p.E232Q	MIR935_hsa-mir-935|MI0005757_5'Flank	NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	233					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GCGCAGCCGCGAGGCGCACTG	0.577													0	0	0	0.000602214	0	4	6										C	54485522	G	C	54485522	3	2	52	1	0	0	0	0	1	0	0	0	2563	1059	37	1	711	1	CACNG8	19	54485522	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1276446	54485522	4643461	257	14600										
SOX12	6666	broad.mit.edu	37	chr20	306839	306839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cggagaagatcccgttcgtgCgggaggcggagcggctgcgg	20	10	0	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:306839C>T	uc002wdh.2	+	1	601	c.271C>T	c.(271-273)CGG>TGG	p.R91W		NM_006943	NP_008874	O15370	SOX12_HUMAN	SRY (sex determining region Y)-box 12	91	HMG box.				cell fate commitment|spinal cord development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|transcription regulatory region sequence-specific DNA binding				0		all_cancers(10;0.000331)|Lung NSC(37;0.0496)|all_lung(30;0.0831)|all_epithelial(17;0.0868)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCCGTTCGTGCGGGAGGCGGA	0.567													0	0	0	3.59834e-05	0	6	30										T	306839	C	T	306839	3	4	52	1	0	0	0	0	1	0	0	0	14943	759	27	2	273	2	SOX12	20	306839	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08		306839	62718681	258	14601										
IDH3B	3420	broad.mit.edu	37	chr20	2640192	2640192	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ttgccaactttgatcaccttCttcaccgcatctgcgatcat	5	14	5	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:2640192C>T	uc002wgp.2	-	11	1059	c.1050G>A	c.(1048-1050)AAG>AAA	p.K350K	IDH3B_uc002wgq.2_Silent_p.K350K|IDH3B_uc002wgr.2_Silent_p.K198K	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	350					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	TGATCACCTTCTTCACCGCAT	0.507													0	0	0	0.000147903	0	64	367										T	2640192	C	T	2640192	2	4	52	1	0	0	0	0	0	0	0	1	7497	912	32	1		1	IDH3B	20	2640192	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2333353	2640192	60385328	259	14602										
PROKR2	128674	broad.mit.edu	37	chr20	5282740	5282740	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgggcaccccgttggttctGaggtcaaggtcagcactgga	15	10	3	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:5282740G>C	uc010zqw.1	-	2	1101	c.1101C>G	c.(1099-1101)CTC>CTG	p.L367L	PROKR2_uc010zqx.1_Silent_p.L367L|PROKR2_uc010zqy.1_Silent_p.L367L	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	367	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CGTTGGTTCTGAGGTCAAGGT	0.547										HNSCC(71;0.22)			0	0	0	0.00010058	0	11	56										C	5282740	G	C	5282740	2	2	52	1	0	0	0	0	0	0	0	1	12553	1277	45	1		1	PROKR2	20	5282740	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2642548	5282740	57742780	260	14603										
C20orf134	170487	broad.mit.edu	37	chr20	32255546	32255546	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aaggccatcacacatctcaaGaagcgcagctgctacgtgtc	9	13	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:32255546G>A	uc002wzt.2	+	1	1243	c.243G>A	c.(241-243)AAG>AAA	p.K81K	NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron	NM_001024675	NP_001019846	Q5JWF8	CT134_HUMAN	hypothetical protein LOC170487	81										pancreas(1)	1						CACATCTCAAGAAGCGCAGCT	0.672													0	0	0	0.000274275	0	6	32										A	32255546	G	A	32255546	2	1	52	1	0	0	0	0	0	0	0	1	2087	933	33	1		1	C20orf134	20	32255546	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	26972806	32255546	30769974	261	14604										
CEP250	11190	broad.mit.edu	37	chr20	34092575	34092576	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aacaacctggaagccttaccCcacagccacaaaacctcccc							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:34092575_34092576CC>AA	uc002xcm.2	+	31	7049_7050	c.6378_6379CC>AA	c.(6376-6381)CCCCAC>CCAAAC	p.H2127N	CEP250_uc010zve.1_Missense_Mutation_p.H1495N	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	2127	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AAGCCTTACCCCACAGCCACAA	0.54													0	0	0	6.4e-05	0	7	101										AA	34092576	CC	AA	34092575	3	1	52	1	0	0	0	0	1	0	0	0	3252	610	22	4	6484	4	CEP250	20	34092575	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	1837029	34092575	28932945	262	14605										
ACOT8	10005	broad.mit.edu	37	chr20	44483824	44483824	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaacaaagtagcagtgcaggGagtgcacgtggacgtcttca	14	8	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:44483824G>A	uc002xqa.1	-	2	317	c.236C>T	c.(235-237)TCC>TTC	p.S79F	ACOT8_uc010zxe.1_Missense_Mutation_p.S79F|ACOT8_uc002xqc.1_Intron|ACOT8_uc010zxf.1_Intron|ZSWIM3_uc002xqd.2_5'Flank|ZSWIM3_uc010zxg.1_5'Flank	NM_005469	NP_005460	O14734	ACOT8_HUMAN	peroxisomal acyl-CoA thioesterase 1 isoform a	79					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GCAGTGCAGGGAGTGCACGTG	0.617													0	0	0	0.000147903	0	53	41										A	44483824	G	A	44483824	3	1	52	1	0	0	0	0	1	0	0	0	156	1174	41	1	743	1	ACOT8	20	44483824	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	10391249	44483824	18541696	263	14606										
SLC12A5	57468	broad.mit.edu	37	chr20	44676624	44676624	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	acttcccggctcccagggcaGagaaggagtggggcgatggg	18	10	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:44676624G>A	uc010zxl.1	+	16	2057	c.1981G>A	c.(1981-1983)GAG>AAG	p.E661K	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.E638K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	661					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TCCCAGGGCAGAGAAGGAGTG	0.617													0	0	0	0.000157383	0	8	8										A	44676624	G	A	44676624	3	1	52	1	0	0	0	0	1	0	0	0	14386	943	33	1	2099	1	SLC12A5	20	44676624	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	192800	44676624	18348896	264	14607										
PRIC285	85441	broad.mit.edu	37	chr20	62196310	62196310	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctgctcccaggtgctggcctCaggcagcacctcccggacga	12	17	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:62196310C>G	uc002yfm.2	-	9	4757	c.3865G>C	c.(3865-3867)GAG>CAG	p.E1289Q	PRIC285_uc002yfl.1_Missense_Mutation_p.E720Q	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1289					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTGCTGGCCTCAGGCAGCACC	0.672													0	0	0	0.000219431	0	14	14										G	62196310	C	G	62196310	3	3	52	1	0	0	0	0	1	0	0	0	12485	835	29	1	4132	1	PRIC285	20	62196310	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	17519686	62196310	829210	265	14608										
PRIC285	85441	broad.mit.edu	37	chr20	62196796	62196796	+	Missense_Mutation	SNP	C	C	T													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agagcagtggcggtaccgctCgggctccgcgtgcagcagct							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:62196796C>T	uc002yfm.2	-	9	4271	c.3379G>A	c.(3379-3381)GAG>AAG	p.E1127K	PRIC285_uc002yfl.1_Missense_Mutation_p.E558K	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1127					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CGGTACCGCTCGGGCTCCGCG	0.706													0	0	0	6.40141e-05	0	7	9										T	62196796	C	T	62196796	3	4	52	1	0	0	0	0	1	0	0	0	12485	893	31	1	4618	1	PRIC285	20	62196796	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	486	62196796	828724	266	14609	70	2								
PRIC285	85441	broad.mit.edu	37	chr20	62196802	62196802	+	Missense_Mutation	SNP	C	C	T													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtggcggtaccgctcgggctCcgcgtgcagcagcttccgta							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr20:62196802C>T	uc002yfm.2	-	9	4265	c.3373G>A	c.(3373-3375)GAG>AAG	p.E1125K	PRIC285_uc002yfl.1_Missense_Mutation_p.E556K	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1125					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CGCTCGGGCTCCGCGTGCAGC	0.701													0	0	0	6.40141e-05	0	7	9										T	62196802	C	T	62196802	3	4	52	1	0	0	0	0	1	0	0	0	12485	864	30	1	4624	1	PRIC285	20	62196802	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6	62196802	828718	267	14610	70	2								
NRIP1	8204	broad.mit.edu	37	chr21	16338775	16338776	+	Missense_Mutation	DNP	GG	GG	TT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagtactgcagacatatggtGgggaattccatttgatgacc							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:16338775_16338776GG>TT	uc002yjx.2	-	4	2336_2337	c.1738_1739CC>AA	c.(1738-1740)CCA>AAA	p.P580K		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	580	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GACATATGGTGGGGAATTCCAT	0.45													0	0	0	6.4e-05	0	14	402										TT	16338776	GG	TT	16338775	3	4	52	1	0	0	0	0	1	0	0	0	10652	1348	47	4	1741	4	NRIP1	21	16338775	Missense_Mutation	DNP	GG	TCGA-DK-A2I1-01A-11D-A17V-08		16338775	31791120	268	14611										
KRTAP13-1	140258	broad.mit.edu	37	chr21	31768675	31768675	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaacctccttgctctgcagtCcctgccagacaacttactct	6	16	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:31768675C>G	uc002yoa.2	+	1	284	c.271C>G	c.(271-273)CCC>GCC	p.P91A		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	91	5 X 10 AA approximate repeats.					intermediate filament				ovary(1)	1						GCTCTGCAGTCCCTGCCAGAC	0.617													0	0	0	0.00010058	0	11	45										G	31768675	C	G	31768675	3	3	52	1	0	0	0	0	1	0	0	0	8522	855	30	1	273	1	KRTAP13-1	21	31768675	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	15429900	31768675	16361220	269	14612										
GART	2618	broad.mit.edu	37	chr21	34883639	34883639	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccctcagaatctgctctgtcTgctcctttgataccacaagg	7	14	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:34883639T>C	uc002yrx.2	-	17	2369	c.2234A>G	c.(2233-2235)CAG>CGG	p.Q745R	GART_uc002yrz.2_Missense_Mutation_p.Q745R|GART_uc010gmd.2_Missense_Mutation_p.Q407R|GART_uc002yry.2_Missense_Mutation_p.Q745R	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	745	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	CTGCTCTGTCTGCTCCTTTGA	0.512													0	0	0	0.000147903	0	124	236										C	34883639	T	C	34883639	3	2	52	1	0	0	0	0	1	0	0	0	6243	1580	55	5	822	5	GART	21	34883639	Missense_Mutation	SNP	T	TCGA-DK-A2I1-01A-11D-A17V-08	3114964	34883639	13246256	270	14613										
DSCAM	1826	broad.mit.edu	37	chr21	41505787	41505787	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cacccgtctctcaccatcctCtttggtccgggtgaagatct	8	15	4	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:41505787C>G	uc002yyq.1	-	19	4008	c.3556G>C	c.(3556-3558)GAG>CAG	p.E1186Q	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1186	Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCACCATCCTCTTTGGTCCGG	0.597													0	0	0	7.07596e-05	0	17	95										G	41505787	C	G	41505787	3	3	52	1	0	0	0	0	1	0	0	0	4768	922	32	1	2542	1	DSCAM	21	41505787	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6622148	41505787	6624108	271	14614										
RRP1B	23076	broad.mit.edu	37	chr21	45104496	45104496	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agcaggaagaacacgccccaCttcaacaggaagcgcctctc	9	15	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:45104496C>T	uc002zdk.2	+	10	1068	c.954C>T	c.(952-954)CAC>CAT	p.H318H	RRP1B_uc002zdl.2_5'Flank	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	318					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		ACACGCCCCACTTCAACAGGA	0.483													0	0	0	9.7654e-05	0	18	80										T	45104496	C	T	45104496	2	4	52	1	0	0	0	0	0	0	0	1	13688	564	20	2		2	RRP1B	21	45104496	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	3598709	45104496	3025399	272	14615										
TRPM2	7226	broad.mit.edu	37	chr21	45795809	45795809	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ctcacttcatcctcgtggacGacgggacccacggccagtac	10	16	2	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:45795809G>C	uc002zet.1	+	7	1078	c.865G>C	c.(865-867)GAC>CAC	p.D289H	TRPM2_uc002zeu.1_Missense_Mutation_p.D289H|TRPM2_uc002zew.1_Missense_Mutation_p.D289H|TRPM2_uc010gpt.1_Missense_Mutation_p.D289H|TRPM2_uc002zex.1_Missense_Mutation_p.D75H	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	289	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCTCGTGGACGACGGGACCCA	0.587													0	0	0	0.000132079	0	19	50										C	45795809	G	C	45795809	3	2	52	1	0	0	0	0	1	0	0	0	16583	1058	37	1	887	1	TRPM2	21	45795809	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	691313	45795809	2334086	273	14616										
MCM3AP	8888	broad.mit.edu	37	chr21	47693430	47693430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cactggcaagggccgcagctCgtggggcaggggctcctcct	16	14	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr21:47693430C>T	uc002zir.1	-	7	2104	c.2068G>A	c.(2068-2070)GAG>AAG	p.E690K		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	690					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					GGCCGCAGCTCGTGGGGCAGG	0.612													0	0	0	0.00047179	0	23	44										T	47693430	C	T	47693430	3	4	52	1	0	0	0	0	1	0	0	0	9388	893	31	1	3962	1	MCM3AP	21	47693430	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	1897621	47693430	436465	274	14617										
PIWIL3	440822	broad.mit.edu	37	chr22	25131704	25131705	+	Missense_Mutation	DNP	GG	GG	TT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggtttcatagttatgcccatGggggctgtgacactctgtag							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:25131704_25131705GG>TT	uc003abd.1	-	13	2021_2022	c.1604_1605CC>AA	c.(1603-1605)CCC>CAA	p.P535Q	PIWIL3_uc011ajx.1_Missense_Mutation_p.P426Q|PIWIL3_uc011ajy.1_Missense_Mutation_p.P426Q|PIWIL3_uc010gut.1_Missense_Mutation_p.P535Q	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	535					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TTATGCCCATGGGGGCTGTGAC	0.386													0	0	0	6.4e-05	0	8	234										TT	25131705	GG	TT	25131704	3	4	52	1	0	0	0	0	1	0	0	0	11959	1335	47	4	1079	4	PIWIL3	22	25131704	Missense_Mutation	DNP	GG	TCGA-DK-A2I1-01A-11D-A17V-08		25131704	26172862	275	14618										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31859020	31859020	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cagttcgatggtttcagactGacttgtgggtccagcagaga	13	8	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:31859020G>A	uc003akz.1	-	6	849	c.685C>T	c.(685-687)CAG>TAG	p.Q229*	EIF4ENIF1_uc003ala.1_Nonsense_Mutation_p.Q229*|EIF4ENIF1_uc003alb.1_Intron	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	229						nucleus	protein binding|protein transporter activity			ovary(1)	1						GTTTCAGACTGACTTGTGGGT	0.448													0	0	0	0.000566183	0	17	55										A	31859020	G	A	31859020	4	1	52	1	0	0	0	0	0	1	0	0	5035	1299	45	1	2331	1	EIF4ENIF1	22	31859020	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	6727316	31859020	19445546	276	14619										
SH3BP1	23616	broad.mit.edu	37	chr22	38061588	38061588	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ggagcctggccgctgcagtgGagacagcctcgggacgccag	17	13	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:38061588G>T	uc003atj.1	+	17	2415	c.1528G>T	c.(1528-1530)GAG>TAG	p.E510*	PDXP_uc003atm.1_Nonsense_Mutation_p.E201*			Q9Y3L3	3BP1_HUMAN	SubName: Full=cDNA FLJ44925 fis, clone BRAMY3014613, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1);	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CGCTGCAGTGGAGACAGCCTC	0.662													1	0	2.0095e-06	8.12818e-05	3.15297e-05	7	24										T	38061588	G	T	38061588	4	4	52	1	0	0	0	0	0	1	0	0	14244	1175	41	3		3	SH3BP1	22	38061588	Nonsense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	6202568	38061588	13242978	277	14620										
NPTXR	23467	broad.mit.edu	37	chr22	39218743	39218743	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgcagttggcaatgcccagGacctgggctggtgtcagggc	17	10	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:39218743G>A	uc003awk.2	-	5	1528	c.1374C>T	c.(1372-1374)GTC>GTT	p.V458V		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	458	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CAATGCCCAGGACCTGGGCTG	0.617													0	0	0	0.00024832	0	4	25										A	39218743	G	A	39218743	2	1	52	1	0	0	0	0	0	0	0	1	10604	1161	41	1		1	NPTXR	22	39218743	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1157155	39218743	12085823	278	14621										
GRAP2	9402	broad.mit.edu	37	chr22	40343185	40343185	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tttcacactggagatgttttGaaggtaggtgacctggggcc	14	7	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:40343185G>C	uc003ayh.1	+	2	338	c.75G>C	c.(73-75)TTG>TTC	p.L25F	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Intron|GRAP2_uc011aon.1_Intron|GRAP2_uc010gya.1_Missense_Mutation_p.L25F|GRAP2_uc011aoo.1_5'UTR|GRAP2_uc011aop.1_Missense_Mutation_p.L25F|GRAP2_uc011aoq.1_Intron|GRAP2_uc003ayj.1_Missense_Mutation_p.L25F	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	25	SH3 1.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GAGATGTTTTGAAGGTAGGTG	0.483													0	0	0	0.000147903	0	55	70										C	40343185	G	C	40343185	3	2	52	1	0	0	0	0	1	0	0	0	6754	1281	45	1	77	1	GRAP2	22	40343185	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	1124442	40343185	10961381	279	14622										
MCHR1	2847	broad.mit.edu	37	chr22	41077227	41077227	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagaccatgtgcaccctcatCacggccatggatgccaatag	10	13	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:41077227C>T	uc003ayz.2	+	2	832	c.564C>T	c.(562-564)ATC>ATT	p.I188I	MCHR1_uc003aza.2_Silent_p.I77I	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	188	Helical; Name=3; (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						GCACCCTCATCACGGCCATGG	0.572													0	0	0	0.000147903	0	47	49										T	41077227	C	T	41077227	2	4	52	1	0	0	0	0	0	0	0	1	9382	816	29	1		1	MCHR1	22	41077227	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	734042	41077227	10227339	280	14623										
SCUBE1	80274	broad.mit.edu	37	chr22	43606163	43606163	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgcgatgtgccagacgcattCagcgttggctgggtagtcgc	15	11	1	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chr22:43606163C>T	uc003bdt.1	-	19	2555	c.2467G>A	c.(2467-2469)GAA>AAA	p.E823K		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	823	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CAGACGCATTCAGCGTTGGCT	0.627													0	0	0	0.000151284	0	14	19										T	43606163	C	T	43606163	3	4	52	1	0	0	0	0	1	0	0	0	13944	835	29	1	515	1	SCUBE1	22	43606163	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	2528936	43606163	7698403	281	14624										
ASMTL	8623	broad.mit.edu	37	chrX	1540663	1540663	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	atgtgaggtcattattgtgcAtgatgaagccgtgcagagag	14	5	1	4			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:1540663A>G	uc004cpx.1	-	9	1244	c.1133T>C	c.(1132-1134)ATG>ACG	p.M378T	ASMTL_uc011mhe.1_Missense_Mutation_p.M302T|ASMTL_uc004cpy.1_Missense_Mutation_p.M362T|ASMTL_uc011mhf.1_Missense_Mutation_p.M320T	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	378	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATTATTGTGCATGATGAAGCC	0.522													0	0	0	3.86212e-05	0	11	522										G	1540663	A	G	1540663	3	3	52	1	0	0	0	0	1	0	0	0	1046	217	8	5	752	5	ASMTL	23	1540663	Missense_Mutation	SNP	A	TCGA-DK-A2I1-01A-11D-A17V-08		1540663	153729897	282	14625										
TLR8	51311	broad.mit.edu	37	chrX	12937404	12937404	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cacacacataacgaatgaatCatttcaagggctgcaaaatc	6	10	2	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:12937404C>G	uc004cve.2	+	2	313	c.245C>G	c.(244-246)TCA>TGA	p.S82*	TLR8_uc004cvd.2_Nonsense_Mutation_p.S100*	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	82	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						ACGAATGAATCATTTCAAGGG	0.413													0	0	0	0.000602214	0	5	187										G	12937404	C	G	12937404	4	3	52	1	0	0	0	0	0	1	0	0	15954	838	29	1	251	1	TLR8	23	12937404	Nonsense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	11396741	12937404	142333156	283	14626										
ZRSR2	8233	broad.mit.edu	37	chrX	15838418	15838419	+	Missense_Mutation	DNP	CG	CG	AT													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gtgaattctgccccgtgaccCggtggaaaatggcgatttgt							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:15838418_15838419CG>AT	uc004cxg.3	+	10	961_962	c.916_917CG>AT	c.(916-918)CGG>ATG	p.R306M		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	306	C3H1-type 2.				spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					CCCCGTGACCCGGTGGAAAATG	0.441													0	0	0	6.4e-05	0	7	213										AT	15838419	CG	AT	15838418	3	1	52	1	0	0	0	0	1	0	0	0	18222	643	23	4	954	4	ZRSR2	23	15838418	Missense_Mutation	DNP	CG	TCGA-DK-A2I1-01A-11D-A17V-08	2901014	15838418	139432142	284	14627										
NUDT10	170685	broad.mit.edu	37	chrX	51075911	51075911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	tccggagcgagcgcgaggacGaggtcctgttagtgagtagc	17	9	0	1			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:51075911G>A	uc004dph.2	+	2	314	c.94G>A	c.(94-96)GAG>AAG	p.E32K	NUDT10_uc004dpi.3_Missense_Mutation_p.E32K	NM_153183	NP_694853	Q8NFP7	NUD10_HUMAN	nudix-type motif 10	32	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					GCGCGAGGACGAGGTCCTGTT	0.687													0	0	0	0.000157383	0	7	25										A	51075911	G	A	51075911	3	1	52	1	0	0	0	0	1	0	0	0	10726	1059	37	1	96	1	NUDT10	23	51075911	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	35237493	51075911	104194649	285	14628										
SLC7A3	84889	broad.mit.edu	37	chrX	70148785	70148785	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gcaatggacccctgcagagtCttagagatgtggttcccaat	11	10	1	2			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:70148785C>T	uc004dyn.2	-	3	596	c.438G>A	c.(436-438)AAG>AAA	p.K146K	SLC7A3_uc004dyo.2_Silent_p.K146K	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	146	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CCTGCAGAGTCTTAGAGATGT	0.542													0	0	0	0.00010058	0	12	61										T	70148785	C	T	70148785	2	4	52	1	0	0	0	0	0	0	0	1	14698	912	32	1		1	SLC7A3	23	70148785	Silent	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	19072874	70148785	85121775	286	14629										
AGTR2	186	broad.mit.edu	37	chrX	115304028	115304029	+	Missense_Mutation	DNP	CC	CC	AA													0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	caagcatcttatatagttccCcttgtttggtgtatggcctg							TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:115304028_115304029CC>AA	uc004eqh.3	+	3	702_703	c.495_496CC>AA	c.(493-498)CCCCTT>CCAATT	p.L166I		NM_000686	NP_000677	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	166	Helical; Name=4; (Potential).				behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3						ATATAGTTCCCCTTGTTTGGTG	0.396													0	0	0	6.4e-05	0	14	397										AA	115304029	CC	AA	115304028	3	1	52	1	0	0	0	0	1	0	0	0	402	610	22	4	497	4	AGTR2	23	115304028	Missense_Mutation	DNP	CC	TCGA-DK-A2I1-01A-11D-A17V-08	45155243	115304028	39966532	287	14630										
THOC2	57187	broad.mit.edu	37	chrX	122756965	122756965	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	aataagcataccagtctcctCagtactgctttcatccgatt	5	12	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:122756965C>T	uc004etu.2	-	29	3705	c.3673G>A	c.(3673-3675)GAG>AAG	p.E1225K	THOC2_uc010nqt.1_5'Flank|THOC2_uc004etw.1_Missense_Mutation_p.E46K	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1225					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						CCAGTCTCCTCAGTACTGCTT	0.403													0	0	0	0.000375601	0	24	93										T	122756965	C	T	122756965	3	4	52	1	0	0	0	0	1	0	0	0	15862	835	29	1	1148	1	THOC2	23	122756965	Missense_Mutation	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	7452937	122756965	32513595	288	14631										
ELF4	2000	broad.mit.edu	37	chrX	129208117	129208117	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	cgaggtggcctcattgtcatCtggtccgggttccatggtgg	15	10	3	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:129208117C>G	uc004evd.3	-	4	633	c.248_splice	c.e4-1	p.D83_splice	ELF4_uc004eve.3_Splice_Site_p.D83_splice	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4						natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCATTGTCATCTGGTCCGGGT	0.532			T	ERG	AML								0	0	0	0.000147903	0	53	165										G	129208117	C	G	129208117	5	3	52	1	0	0	0	0	0	0	1	0	5056	927	32	1	1768	1	ELF4	23	129208117	Splice_Site	SNP	C	TCGA-DK-A2I1-01A-11D-A17V-08	6451152	129208117	26062443	289	14632										
PHF6	84295	broad.mit.edu	37	chrX	133549106	133549106	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gagcagaatttggagactttGatattaaaactgtacttcag	9	5	1	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:133549106G>C	uc004exj.2	+	8	992	c.790G>C	c.(790-792)GAT>CAT	p.D264H	PHF6_uc004exk.2_Missense_Mutation_p.D264H|PHF6_uc011mvk.1_Missense_Mutation_p.D230H|PHF6_uc004exh.2_Missense_Mutation_p.D265H|PHF6_uc010nrr.2_Missense_Mutation_p.D264H|PHF6_uc004exi.2_Missense_Mutation_p.D265H	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TGGAGACTTTGATATTAAAAC	0.333													0	0	0	0.000147903	0	53	80										C	133549106	G	C	133549106	3	2	52	1	0	0	0	0	1	0	0	0	11838	1290	45	1	819	1	PHF6	23	133549106	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	4340989	133549106	21721454	290	14633										
FGF13	2258	broad.mit.edu	37	chrX	137939732	137939732	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	agcgggcagcagaagatttcGtgacacttagcacgaaaggg	14	8	0	3			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:137939732G>A	uc004faq.2	-	2	335	c.159C>T	c.(157-159)CAC>CAT	p.H53H	FGF13_uc011mwi.1_Silent_p.H24H|FGF13_uc004far.2_Silent_p.H24H|FGF13_uc011mwj.1_Silent_p.H53H|FGF13_uc011mwk.1_Intron	NM_001139502	NP_001132974	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 3	Error:Variant_position_missing_in_Q92913_after_alignment					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AGAAGATTTCGTGACACTTAG	0.478													0	0	0	0.000147903	0	65	149										A	137939732	G	A	137939732	2	1	52	1	0	0	0	0	0	0	0	1	5842	1136	40	2		2	FGF13	23	137939732	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	4390626	137939732	17330828	291	14634										
PRRG3	79057	broad.mit.edu	37	chrX	150869180	150869180	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	gaaccggtacctagccagtcGcgccgggcacaccctccccc	10	20	0	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:150869180G>A	uc004few.1	+	4	761	c.371G>A	c.(370-372)CGC>CAC	p.R124H		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	124	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTAGCCAGTCGCGCCGGGCAC	0.632													0	0	0	0.000566183	0	18	81										A	150869180	G	A	150869180	3	1	52	1	0	0	0	0	1	0	0	0	12607	1087	38	2	381	2	PRRG3	23	150869180	Missense_Mutation	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	12929448	150869180	4401380	292	14635										
RENBP	5973	broad.mit.edu	37	chrX	153206997	153206997	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486301369863014	142	1.40623067799647e-53	4.04581708613967	5.0939263708383	3.40249483553154	0.564379665941849	0.7111952018206	107	ccgtggtcagggtcccatccGgagtggaagggcaacaatag	15	10	1	0			TCGA-DK-A2I1-01A-11D-A17V-08	TCGA-DK-A2I1-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f350676a-e308-42fe-8297-9d18ba7027b1	bba7b385-f707-4654-ba9e-cd3bbebf4859	g.chrX:153206997G>A	uc004fjo.1	-	8	1049	c.879C>T	c.(877-879)TCC>TCT	p.S293S	RENBP_uc011mzh.1_3'UTR	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	293					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	GGTCCCATCCGGAGTGGAAGG	0.587													0	0	0	0.000184323	0	29	107										A	153206997	G	A	153206997	2	1	52	1	0	0	0	0	0	0	0	1	13225	1103	39	2		2	RENBP	23	153206997	Silent	SNP	G	TCGA-DK-A2I1-01A-11D-A17V-08	2337817	153206997	2063563	293	14636										
PRKCZ	5590	broad.mit.edu	37	chr1	2077537	2077537	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gccgaccttccttccgaggaGacagatggaagtaggcgctg	14	11	0	2	rs143367104		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:2077537G>C	uc001aiq.2	+	7	785	c.624G>C	c.(622-624)GAG>GAC	p.E208D	PRKCZ_uc001air.2_Missense_Mutation_p.E25D|PRKCZ_uc010nyw.1_Missense_Mutation_p.E104D|PRKCZ_uc001ais.2_Missense_Mutation_p.E25D|PRKCZ_uc009vla.2_Missense_Mutation_p.E32D|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc009vlb.2_Missense_Mutation_p.E21D	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	208					anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CTTCCGAGGAGACAGATGGAA	0.582													0	0	0	6.4e-05	0	3	51										C	2077537	G	C	2077537	3	2	53	1	0	0	0	0	1	0	0	0	12517	933	33	1	650	1	PRKCZ	1	2077537	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		2077537	247173084	1	14637										
DFFA	1676	broad.mit.edu	37	chr1	10527261	10527261	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctttacctggaggtcctcctCtgataggaggatgatgctgg	13	9	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:10527261C>T	uc001arj.2	-	3	525	c.427G>A	c.(427-429)GAG>AAG	p.E143K	DFFA_uc001ark.2_Missense_Mutation_p.E143K	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	143					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGGTCCTCCTCTGATAGGAGG	0.532													0	0	0	0.000175454	0	19	114										T	10527261	C	T	10527261	3	4	53	1	0	0	0	0	1	0	0	0	4452	922	32	1	608	1	DFFA	1	10527261	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	8449724	10527261	238723360	2	14638										
EPB41	2035	broad.mit.edu	37	chr1	29379626	29379626	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tctcacatagcagcagctgtCgattcggcagaccgaagtcc	10	13	1	1	rs145888614	byFrequency	TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:29379626C>A	uc001brm.1	+	11	1654	c.1647C>A	c.(1645-1647)GTC>GTA	p.V549V	EPB41_uc001brg.1_Silent_p.V340V|EPB41_uc001brh.1_Silent_p.V340V|EPB41_uc001bri.1_Silent_p.V514V|EPB41_uc001brj.1_Silent_p.V340V|EPB41_uc009vtk.1_Silent_p.V513V|EPB41_uc001brk.2_Silent_p.V549V|EPB41_uc001brl.1_Silent_p.V549V|EPB41_uc009vtl.1_Silent_p.V340V|EPB41_uc009vtm.1_Silent_p.V182V	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	549	Hydrophilic.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		CAGCAGCTGTCGATTCGGCAG	0.483													1	0	5.50884e-06	0.00010058	6.41337e-05	10	32										A	29379626	C	A	29379626	2	1	53	1	0	0	0	0	0	0	0	1	5151	871	31	3		3	EPB41	1	29379626	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	18852365	29379626	219870995	3	14639										
S100PBP	64766	broad.mit.edu	37	chr1	33292110	33292110	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	taaaccattaaacagacgctCtgtactagaaaagaatctta	5	8	2	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:33292110C>G	uc001bvz.2	+	3	687	c.410C>G	c.(409-411)TCT>TGT	p.S137C	S100PBP_uc001bwa.1_Missense_Mutation_p.S137C|S100PBP_uc001bwb.1_Missense_Mutation_p.S137C|S100PBP_uc001bwc.2_Missense_Mutation_p.S137C|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	137						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AACAGACGCTCTGTACTAGAA	0.418													0	0	0	8.12818e-05	0	5	31										G	33292110	C	G	33292110	3	3	53	1	0	0	0	0	1	0	0	0	13791	913	32	1	412	1	S100PBP	1	33292110	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	3912484	33292110	215958511	4	14640										
ERI3	79033	broad.mit.edu	37	chr1	44804820	44804820	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccattgccgccatggatgcgCcaaagccgtgggccgccagc	13	16	0	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:44804820C>T	uc001clt.2	-	3	627	c.386G>A	c.(385-387)GGC>GAC	p.G129D	ERI3_uc010okv.1_Intron|ERI3_uc009vxg.2_Missense_Mutation_p.G129D|ERI3_uc010okw.1_Missense_Mutation_p.G51D|ERI3_uc001clu.2_Missense_Mutation_p.G51D	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	129						intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						CATGGATGCGCCAAAGCCGTG	0.542													0	0	0	0.000308642	0	15	187										T	44804820	C	T	44804820	3	4	53	1	0	0	0	0	1	0	0	0	5229	739	26	2	655	2	ERI3	1	44804820	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	11512710	44804820	204445801	5	14641										
GBP5	115362	broad.mit.edu	37	chr1	89729593	89729593	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tccgaggatgcttccaggttCcgtttacaaatgtcattctg	9	10	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:89729593C>T	uc001dnc.2	-	9	1725	c.1188G>A	c.(1186-1188)CGG>CGA	p.R396R	GBP5_uc001dnd.2_Silent_p.R396R|GBP5_uc001dne.1_Silent_p.R396R	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	396						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		CTTCCAGGTTCCGTTTACAAA	0.383													0	0	0	0.000308642	0	15	122										T	89729593	C	T	89729593	2	4	53	1	0	0	0	0	0	0	0	1	6277	842	30	1		1	GBP5	1	89729593	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	44924773	89729593	159521028	6	14642										
S1PR1	1901	broad.mit.edu	37	chr1	101705363	101705363	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctgggcaccgctcttcatcCtgctcctgctggatgtgggc	13	14	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:101705363C>G	uc001dud.2	+	2	1337	c.823C>G	c.(823-825)CTG>GTG	p.L275V	S1PR1_uc009weg.2_Missense_Mutation_p.L275V	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	275	Helical; Name=6; (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						GCTCTTCATCCTGCTCCTGCT	0.582													0	0	0	0.000319135	0	38	244										G	101705363	C	G	101705363	3	3	53	1	0	0	0	0	1	0	0	0	13793	680	24	4	825	4	S1PR1	1	101705363	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	11975770	101705363	147545258	7	14643										
CTTNBP2NL	55917	broad.mit.edu	37	chr1	112998771	112998771	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cgggtgagtaaactggaagaAgagttggcagctgagagaaa	16	4	0	5			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:112998771A>G	uc001ebx.2	+	6	885	c.657A>G	c.(655-657)GAA>GAG	p.E219E	CTTNBP2NL_uc001ebz.2_5'Flank	NM_018704	NP_061174	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	219	Potential.					actin cytoskeleton	protein binding			central_nervous_system(2)|ovary(1)	3		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AACTGGAAGAAGAGTTGGCAG	0.512													0	0	0	0.000442599	0	9	59										G	112998771	A	G	112998771	2	3	53	1	0	0	0	0	0	0	0	1	4046	69	3	5		5	CTTNBP2NL	1	112998771	Silent	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	11293408	112998771	136251850	8	14644										
PDE4DIP	9659	broad.mit.edu	37	chr1	144859924	144859924	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctgctccagctgccctctcaGagctcgtacctctgccacca	7	19	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:144859924G>A	uc001elw.3	-	38	6451	c.6160C>T	c.(6160-6162)CTG>TTG	p.L2054L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1948L|PDE4DIP_uc001elv.3_Silent_p.L1061L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2054	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGCCCTCTCAGAGCTCGTACC	0.577			T	PDGFRB	MPD								0	0	0	0.000274275	0	9	100										A	144859924	G	A	144859924	2	1	53	1	0	0	0	0	0	0	0	1	11643	933	33	1		1	PDE4DIP	1	144859924	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	31861153	144859924	104390697	9	14645										
FLG	2312	broad.mit.edu	37	chr1	152284039	152284039	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctgaacgtccagaccttcccCctgaccagtcacgtgcggac	9	17	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:152284039C>T	uc001ezu.1	-	3	3359	c.3323G>A	c.(3322-3324)GGG>GAG	p.G1108E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1108	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCTTCCCCCTGACCAGTC	0.582									Ichthyosis				0	0	0	0.000781405	0	57	258										T	152284039	C	T	152284039	3	4	53	1	0	0	0	0	1	0	0	0	5922	623	22	2	8866	2	FLG	1	152284039	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	7424115	152284039	96966582	10	14646										
CRTC2	200186	broad.mit.edu	37	chr1	153921053	153921053	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	caccccctaaaaatccaggcCcttcagaaaagccaggggga	9	14	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:153921053C>G	uc010ped.1	-	13	1812	c.1742G>C	c.(1741-1743)GGG>GCG	p.G581A	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Missense_Mutation_p.G117A	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	581					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAATCCAGGCCCTTCAGAAAA	0.567													0	0	0	0.000274275	0	8	109										G	153921053	C	G	153921053	3	3	53	1	0	0	0	0	1	0	0	0	3900	623	22	4	347	4	CRTC2	1	153921053	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	1637014	153921053	95329568	11	14647			1	57		2	2	15	N	C_A	6.421666e-05
CRTC2	200186	broad.mit.edu	37	chr1	153921067	153921067	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccaggcccttcagaaaagccAgggggatccagcaccaggct	12	14	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:153921067A>G	uc010ped.1	-	13	1798	c.1728T>C	c.(1726-1728)CCT>CCC	p.P576P	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Silent_p.P112P	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	576					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGAAAAGCCAGGGGGATCCA	0.542													0	0	0	0.000673444	0	10	108										G	153921067	A	G	153921067	2	3	53	1	0	0	0	0	0	0	0	1	3900	175	7	5		5	CRTC2	1	153921067	Silent	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	14	153921067	95329554	12	14648			1	57		2	2	15	N	C_A	6.421666e-05
GON4L	54856	broad.mit.edu	37	chr1	155721969	155721969	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cacgtcctgtctcttgtcttCacccgagctctgcttgaggg	10	14	4	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:155721969C>T	uc001flz.2	-	30	6352	c.6255G>A	c.(6253-6255)GTG>GTA	p.V2085V	GON4L_uc001flx.1_5'Flank|GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Silent_p.V2084V|GON4L_uc009wrh.1_Silent_p.V2084V|GON4L_uc001fma.1_Silent_p.V2085V	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	2085					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CTCTTGTCTTCACCCGAGCTC	0.527													0	0	0	0.000308642	0	16	141										T	155721969	C	T	155721969	2	4	53	1	0	0	0	0	0	0	0	1	6572	813	29	1		1	GON4L	1	155721969	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	1800902	155721969	93528652	13	14649										
LAMB3	3914	broad.mit.edu	37	chr1	209799289	209799289	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cactggtcacagcggggcccGgtcaagccagggcggcagag	17	13	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:209799289G>C	uc001hhg.2	-	13	2070	c.1680C>G	c.(1678-1680)ACC>ACG	p.T560T	LAMB3_uc009xco.2_Silent_p.T560T|LAMB3_uc001hhh.2_Silent_p.T560T|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	560	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGCGGGGCCCGGTCAAGCCAG	0.647													0	0	0	0.000602214	0	5	57										C	209799289	G	C	209799289	2	2	53	1	0	0	0	0	0	0	0	1	8612	1103	39	4		4	LAMB3	1	209799289	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	54077320	209799289	39451332	14	14650										
SPATA17	128153	broad.mit.edu	37	chr1	217915425	217915425	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gcccgaaagatgcattacctCctcagcacaaagcaggttgg	10	12	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:217915425C>T	uc001hlh.1	+	6	530	c.504C>T	c.(502-504)CTC>CTT	p.L168L	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.L168L	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	168						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TGCATTACCTCCTCAGCACAA	0.473													0	0	0	8.12818e-05	0	7	85										T	217915425	C	T	217915425	2	4	53	1	0	0	0	0	0	0	0	1	15001	842	30	1		1	SPATA17	1	217915425	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	8116136	217915425	31335196	15	14651										
CDC42BPA	8476	broad.mit.edu	37	chr1	227316871	227316871	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttttttatttctaaatctttGcttgctgttagtggaccatc	6	7	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:227316871G>A	uc001hqr.2	-	11	2395	c.1452C>T	c.(1450-1452)AGC>AGT	p.S484S	CDC42BPA_uc001hqs.2_Silent_p.S484S|CDC42BPA_uc009xes.2_Silent_p.S484S|CDC42BPA_uc010pvs.1_Silent_p.S484S	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	484	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTAAATCTTTGCTTGCTGTTA	0.289													0	0	0	0.000157383	0	7	62										A	227316871	G	A	227316871	2	1	53	1	0	0	0	0	0	0	0	1	3072	1310	46	2		2	CDC42BPA	1	227316871	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	9401446	227316871	21933750	16	14652										
PLD5	200150	broad.mit.edu	37	chr1	242253336	242253336	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttaatgatgcttctgttgttCctcacatctgcctggttgat	8	9	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:242253336C>T	uc001hzn.1	-	10	1558	c.1431G>A	c.(1429-1431)AGG>AGA	p.R477R	PLD5_uc001hzl.3_Silent_p.R415R|PLD5_uc001hzm.3_Silent_p.R267R|PLD5_uc001hzo.1_Silent_p.R385R			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	477						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TTCTGTTGTTCCTCACATCTG	0.423													0	0	0	8.12818e-05	0	6	98										T	242253336	C	T	242253336	2	4	53	1	0	0	0	0	0	0	0	1	12049	854	30	1		1	PLD5	1	242253336	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	14936465	242253336	6997285	17	14653										
OR2M2	391194	broad.mit.edu	37	chr1	248344190	248344190	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aaggaggtgactagagcattCatgaagatcttaggaaaggg	14	4	2	4			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr1:248344190C>T	uc010pzf.1	+	1	903	c.903C>T	c.(901-903)TTC>TTT	p.F301F		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTAGAGCATTCATGAAGATCT	0.423													0	0	0	0.000175454	0	21	105										T	248344190	C	T	248344190	2	4	53	1	0	0	0	0	0	0	0	1	11010	825	29	1		1	OR2M2	1	248344190	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	6090854	248344190	906431	18	14654										
ALK	238	broad.mit.edu	37	chr2	29917721	29917721	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cagcctctcccttacctctgGgcatctccttagaacgctct	6	17	4	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:29917721G>C	uc002rmy.2	-	3	1854	c.947C>G	c.(946-948)CCC>CGC	p.P316R		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	316	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTTACCTCTGGGCATCTCCTT	0.587			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.000227799	0	25	80										C	29917721	G	C	29917721	3	2	53	1	0	0	0	0	1	0	0	0	525	1232	43	4	4023	4	ALK	2	29917721	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		29917721	213281652	19	14655										
MOGS	7841	broad.mit.edu	37	chr2	74688895	74688895	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gttggggccgacccaccaccCgaacgagcccctgagggggc	15	16	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:74688895C>T	uc010ffj.2	-	4	2184	c.2021G>A	c.(2020-2022)CGG>CAG	p.R674Q	MOGS_uc010ffh.2_Missense_Mutation_p.R399Q|MOGS_uc010yrt.1_Missense_Mutation_p.R555Q|MOGS_uc010ffi.2_Missense_Mutation_p.R568Q	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	674	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						ACCCACCACCCGAACGAGCCC	0.582													0	0	0	0.000442599	0	9	99										T	74688895	C	T	74688895	3	4	53	1	0	0	0	0	1	0	0	0	9697	652	23	2	496	2	MOGS	2	74688895	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	44771174	74688895	168510478	20	14656										
SEMA4C	54910	broad.mit.edu	37	chr2	97530101	97530101	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aactggtactcacagatggcCgacaggtacatgtcacccct	9	13	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:97530101C>T	uc002sxh.3	-	10	1141	c.981G>A	c.(979-981)TCG>TCA	p.S327S	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Silent_p.S380S	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	327	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						CACAGATGGCCGACAGGTACA	0.582													0	0	0	0.00074312	0	16	162										T	97530101	C	T	97530101	2	4	53	1	0	0	0	0	0	0	0	1	14033	639	23	2		2	SEMA4C	2	97530101	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	22841206	97530101	145669272	21	14657										
DDX18	8886	broad.mit.edu	37	chr2	118575041	118575041	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ggcctcaaatctgaccctatCggaaactcaaaatggagatg	9	10	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:118575041C>T	uc002tlh.1	+	2	206	c.107C>T	c.(106-108)TCG>TTG	p.S36L		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	36							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						CTGACCCTATCGGAAACTCAA	0.358													0	0	0	0.000157383	0	7	87										T	118575041	C	T	118575041	3	4	53	1	0	0	0	0	1	0	0	0	4345	893	31	1	113	1	DDX18	2	118575041	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	21044940	118575041	124624332	22	14658										
COL5A2	1290	broad.mit.edu	37	chr2	189904075	189904075	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttttcgagccatcggggctgCgcatggtttcaatctgacta	11	10	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:189904075C>T	uc002uqk.2	-	51	4123	c.3848G>A	c.(3847-3849)CGC>CAC	p.R1283H	COL5A2_uc010frx.2_Missense_Mutation_p.R859H	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1283	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ATCGGGGCTGCGCATGGTTTC	0.522													0	0	0	0.000157383	0	7	53										T	189904075	C	T	189904075	3	4	53	1	0	0	0	0	1	0	0	0	3697	768	27	2	667	2	COL5A2	2	189904075	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	71329034	189904075	53295298	23	14659										
DIS3L2	129563	broad.mit.edu	37	chr2	233198629	233198629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctcaatgtgcccctgtacaCacacttcacctcgcccatcc	5	19	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr2:233198629C>T	uc010fxz.2	+	17	2366	c.2090C>T	c.(2089-2091)ACA>ATA	p.T697I	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_5'Flank	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	697							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CCCCTGTACACACACTTCACC	0.662													0	0	0	0.00074312	0	18	92										T	233198629	C	T	233198629	3	4	53	1	0	0	0	0	1	0	0	0	4537	478	17	2	2152	2	DIS3L2	2	233198629	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	43294554	233198629	10000744	24	14660										
TRANK1	9881	broad.mit.edu	37	chr3	36872485	36872485	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cccacgtgactgtggatccaTacactttgctcgatgtcctg	9	13	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:36872485T>C	uc003cgj.2	-	12	7109	c.6807A>G	c.(6805-6807)GTA>GTG	p.V2269V		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2819					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGTGGATCCATACACTTTGCT	0.532													0	0	0	0.000781405	0	43	143										C	36872485	T	C	36872485	2	2	53	1	0	0	0	0	0	0	0	1	16451	1393	49	5		5	TRANK1	3	36872485	Silent	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08		36872485	161149945	25	14661										
KLHDC8B	200942	broad.mit.edu	37	chr3	49213182	49213182	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gtttgttattgggggtgtggCccagggccccagtcaagccg	16	10	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:49213182C>T	uc003cwh.2	+	6	1198	c.1013C>T	c.(1012-1014)GCC>GTC	p.A338V	KLHDC8B_uc003cwi.1_3'UTR	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	338	Kelch 8.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGGGGTGTGGCCCAGGGCCCC	0.662													0	0	0	0.000673444	0	10	58										T	49213182	C	T	49213182	3	4	53	1	0	0	0	0	1	0	0	0	8363	739	26	2	1031	2	KLHDC8B	3	49213182	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	12340697	49213182	148809248	26	14662										
TRAT1	50852	broad.mit.edu	37	chr3	108565976	108565976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	acttagatgatatgatttcaGgtaagttttccataagttaa	7	4	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:108565976G>A	uc003dxi.1	+	4	358	c.214G>A	c.(214-216)GAA>AAA	p.E72K	TRAT1_uc010hpx.1_Missense_Mutation_p.E35K	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	72	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						TATGATTTCAGGTAAGTTTTC	0.274													0	0	0	0.000602214	0	5	30										A	108565976	G	A	108565976	3	1	53	1	0	0	0	0	1	0	0	0	16463	1014	35	2	228	2	TRAT1	3	108565976	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	59352794	108565976	89456454	27	14663										
ZDHHC23	254887	broad.mit.edu	37	chr3	113675335	113675335	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	agctcttttctattgtcctgGagtttatgcaaattacaggt	8	7	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:113675335G>A	uc003eau.2	+	4	1321	c.1022G>A	c.(1021-1023)GGA>GAA	p.G341E	ZDHHC23_uc003eav.2_Missense_Mutation_p.G335E|ZDHHC23_uc003eaw.1_5'Flank	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	341						integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						TATTGTCCTGGAGTTTATGCA	0.463													0	0	0	3.59834e-05	0	6	72										A	113675335	G	A	113675335	3	1	53	1	0	0	0	0	1	0	0	0	17611	1174	41	1	1032	1	ZDHHC23	3	113675335	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	5109359	113675335	84347095	28	14664										
COL6A6	131873	broad.mit.edu	37	chr3	130311550	130311550	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttattttcagggaaacagagGactaaatggacaggaggtat	12	4	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:130311550G>T	uc010htl.2	+	14	4386	c.4355G>T	c.(4354-4356)GGA>GTA	p.G1452V	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1452	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGAAACAGAGGACTAAATGGA	0.313													1	0	4.34311e-12	0.00058488	5.18424e-11	28	124										T	130311550	G	T	130311550	3	4	53	1	0	0	0	0	1	0	0	0	3703	1174	41	3	4409	3	COL6A6	3	130311550	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	16636215	130311550	67710880	29	14665										
PPP2R3A	5523	broad.mit.edu	37	chr3	135721343	135721343	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctgaacaaccccctaaatatGaagatgttgtccagctctca	6	12	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:135721343G>A	uc003eqv.1	+	2	1568	c.1003G>A	c.(1003-1005)GAA>AAA	p.E335K	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	335					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CCCTAAATATGAAGATGTTGT	0.413													0	0	0	0.000442599	0	7	65										A	135721343	G	A	135721343	3	1	53	1	0	0	0	0	1	0	0	0	12388	1291	45	1	1005	1	PPP2R3A	3	135721343	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	5409793	135721343	62301087	30	14666										
PIK3CB	5291	broad.mit.edu	37	chr3	138478132	138478132	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctatctgtgaatccaccgcCcagatgtcaaggatgtctgc	10	12	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:138478132C>T	uc011bmq.1	-	1	54	c.54G>A	c.(52-54)TGG>TGA	p.W18*		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	18					activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AATCCACCGCCCAGATGTCAA	0.463													0	0	0	0.000602214	0	5	46										T	138478132	C	T	138478132	4	4	53	1	0	0	0	0	0	1	0	0	11914	624	22	2	3244	2	PIK3CB	3	138478132	Nonsense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	2756789	138478132	59544298	31	14667										
SLC33A1	9197	broad.mit.edu	37	chr3	155571496	155571496	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	acatttttgctttgcaaaatGagtgggatgcttcccgccaa	9	9	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:155571496G>A	uc003fan.3	-	1	672	c.291C>T	c.(289-291)CTC>CTT	p.L97L	SLC33A1_uc003fao.1_Silent_p.L97L	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	97	Extracellular (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTTGCAAAATGAGTGGGATGC	0.483													0	0	0	0.000157383	0	8	74										A	155571496	G	A	155571496	2	1	53	1	0	0	0	0	0	0	0	1	14566	1277	45	1		1	SLC33A1	3	155571496	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	17093364	155571496	42450934	32	14668										
GFM1	85476	broad.mit.edu	37	chr3	158408110	158408110	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	actattttacactgtatgcaGatgtaagtagtcttggtcat	8	6	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:158408110G>A	uc003fce.2	+	16	2175	c.2068G>A	c.(2068-2070)GAT>AAT	p.D690N	GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Missense_Mutation_p.D621N	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	690					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			ACTGTATGCAGATGTAAGTAG	0.408													0	0	0	0.000442599	0	9	80										A	158408110	G	A	158408110	3	1	53	1	0	0	0	0	1	0	0	0	6341	942	33	1	2130	1	GFM1	3	158408110	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	2836614	158408110	39614320	33	14669										
ACTL6A	86	broad.mit.edu	37	chr3	179301231	179301231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gagagctgtctcagaaaactCctccagtaagttctgtttgt	9	9	2	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr3:179301231C>T	uc003fjw.2	+	12	1290	c.1117C>T	c.(1117-1119)CCT>TCT	p.P373S	ACTL6A_uc003fjx.2_Missense_Mutation_p.P331S|ACTL6A_uc003fjy.2_Missense_Mutation_p.P331S	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	373					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			TCAGAAAACTCCTCCAGTAAG	0.368													0	0	0	0.000442599	0	9	82										T	179301231	C	T	179301231	3	4	53	1	0	0	0	0	1	0	0	0	198	855	30	1	1163	1	ACTL6A	3	179301231	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	20893121	179301231	18721199	34	14670										
KIAA1530	57654	broad.mit.edu	37	chr4	1374711	1374711	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tccacgggacgacgaaggacGgccgctcgacccggaagaca	14	14	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:1374711G>A	uc003gde.3	+	12	2243	c.1796G>A	c.(1795-1797)CGG>CAG	p.R599Q	KIAA1530_uc010ibv.2_Missense_Mutation_p.R150Q	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	599											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GACGAAGGACGGCCGCTCGAC	0.677													0	0	0	0.00074312	0	13	54										A	1374711	G	A	1374711	3	1	53	1	0	0	0	0	1	0	0	0	8241	1116	39	2	1838	2	KIAA1530	4	1374711	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		1374711	189779565	35	14671										
FAM53A	152877	broad.mit.edu	37	chr4	1643302	1643302	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tcatcgtcatcttcgtaattGagggagcaaaggctttttga	10	7	3	2	rs151156399		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:1643302G>A	uc011bve.1	-	5	1113	c.915C>T	c.(913-915)CTC>CTT	p.L305L	FAM53A_uc010ibw.2_Nonsense_Mutation_p.Q357*	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	305						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			CTTCGTAATTGAGGGAGCAAA	0.502													0	0	0	0.000781405	0	43	319										A	1643302	G	A	1643302	2	1	53	1	0	0	0	0	0	0	0	1	5579	1277	45	1		1	FAM53A	4	1643302	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	268591	1643302	189510974	36	14672										
TACC3	10460	broad.mit.edu	37	chr4	1730206	1730206	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccaccaaggagactgggagaGaggtccggcctcaagcctcc	13	14	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:1730206G>C	uc003gdo.2	+	4	1185	c.1077G>C	c.(1075-1077)GAG>GAC	p.E359D	TACC3_uc010ibz.2_Missense_Mutation_p.E359D|TACC3_uc003gdp.2_Intron|TACC3_uc010ica.2_5'Flank	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	359						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GACTGGGAGAGAGGTCCGGCC	0.597													0	0	0	3.59834e-05	0	5	73										C	1730206	G	C	1730206	3	2	53	1	0	0	0	0	1	0	0	0	15500	933	33	1	1087	1	TACC3	4	1730206	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	86904	1730206	189424070	37	14673										
HAUS3	79441	broad.mit.edu	37	chr4	2242103	2242103	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttgcgataaaaataccagtgGatttgtcccttgacctaaat	7	8	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:2242103G>A	uc003ges.1	-	2	801	c.571C>T	c.(571-573)CCA>TCA	p.P191S	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Missense_Mutation_p.P191S|HAUS3_uc003get.1_Missense_Mutation_p.P191S	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	191					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						aataccagtggatttgtccct	0.035													0	0	0	0.000602214	0	5	27										A	2242103	G	A	2242103	3	1	53	1	0	0	0	0	1	0	0	0	6967	1174	41	1	1256	1	HAUS3	4	2242103	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	511897	2242103	188912173	38	14674										
SH3BP2	6452	broad.mit.edu	37	chr4	2831314	2831314	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccccgggcccactcctttacCtccaagggccccggtcccct	8	22	0	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:2831314C>T	uc003gfi.3	+	8	801	c.681C>T	c.(679-681)ACC>ACT	p.T227T	SH3BP2_uc011bvp.1_Silent_p.T255T|SH3BP2_uc003gfj.3_Silent_p.T284T|SH3BP2_uc003gfk.3_Silent_p.T227T|SH3BP2_uc003gfl.3_Silent_p.T160T|SH3BP2_uc003gfm.3_Silent_p.T202T	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	227					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		ACTCCTTTACCTCCAAGGGCC	0.677									Cherubism				0	0	0	0.000151284	0	13	101										T	2831314	C	T	2831314	2	4	53	1	0	0	0	0	0	0	0	1	14245	668	24	2		2	SH3BP2	4	2831314	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	589211	2831314	188322962	39	14675										
C1QTNF7	114905	broad.mit.edu	37	chr4	15444248	15444248	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aggaaaccatgatgtggcttCggggtccacagtcatctatc	11	10	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:15444248C>T	uc011bxb.1	+	3	922	c.695C>T	c.(694-696)TCG>TTG	p.S232L	C1QTNF7_uc003gno.2_Missense_Mutation_p.S239L|C1QTNF7_uc003gnp.2_Missense_Mutation_p.S232L	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	232	C1q.					collagen					0						GATGTGGCTTCGGGGTCCACA	0.502													0	0	0	0.000781405	0	60	96										T	15444248	C	T	15444248	3	4	53	1	0	0	0	0	1	0	0	0	1968	893	31	1	726	1	C1QTNF7	4	15444248	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	12612934	15444248	175710028	40	14676										
GRID2	2895	broad.mit.edu	37	chr4	94006340	94006340	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	atgactacactctctcagttCgcccacctgtctacttgcat	5	15	3	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:94006340C>G	uc011cdt.1	+	3	697	c.439C>G	c.(439-441)CGC>GGC	p.R147G	GRID2_uc010ikx.2_Missense_Mutation_p.R147G|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	147	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCTCTCAGTTCGCCCACCTGT	0.478													0	0	0	0.000602214	0	5	27										G	94006340	C	G	94006340	3	3	53	1	0	0	0	0	1	0	0	0	6772	884	31	1	449	1	GRID2	4	94006340	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	78562092	94006340	97147936	41	14677										
FBXW7	55294	broad.mit.edu	37	chr4	153244124	153244124	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cacacaccagctttgtgtttGaggctctgatccgccacaca	8	14	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:153244124G>C	uc003ims.2	-	12	2182	c.2033C>G	c.(2032-2034)TCA>TGA	p.S678*	FBXW7_uc011cii.1_Nonsense_Mutation_p.S678*|FBXW7_uc003imt.2_Nonsense_Mutation_p.S678*|FBXW7_uc011cih.1_Nonsense_Mutation_p.S502*|FBXW7_uc003imq.2_Nonsense_Mutation_p.S598*|FBXW7_uc003imr.2_Nonsense_Mutation_p.S560*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	678					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTTTGTGTTTGAGGCTCTGAT	0.493			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.000781405	0	47	52										C	153244124	G	C	153244124	4	2	53	1	0	0	0	0	0	1	0	0	5769	1294	45	1	94	1	FBXW7	4	153244124	Nonsense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	59237784	153244124	37910152	42	14678										
GALNTL6	442117	broad.mit.edu	37	chr4	173269794	173269794	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ataattaaccgaaccccaggGagtctgatagcagaaatcat	8	9	2	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr4:173269794G>A	uc003isv.2	+	5	1243	c.507G>A	c.(505-507)GGG>GGA	p.G169G		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	169	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GAACCCCAGGGAGTCTGATAG	0.403													0	0	0	0.000219431	0	14	29										A	173269794	G	A	173269794	2	1	53	1	0	0	0	0	0	0	0	1	6225	1161	41	1		1	GALNTL6	4	173269794	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	20025670	173269794	17884482	43	14679										
RASA1	5921	broad.mit.edu	37	chr5	86645051	86645051	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttggtcaagtctgcagttttCttgtgaggccctcagataat	10	8	4	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:86645051C>G	uc003kiw.2	+	8	1241	c.1123C>G	c.(1123-1125)CTT>GTT	p.L375V	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.L198V|RASA1_uc011ctv.1_Missense_Mutation_p.L208V|RASA1_uc011ctw.1_Missense_Mutation_p.L209V|RASA1_uc010jaw.2_Missense_Mutation_p.L197V	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	375	SH2 2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CTGCAGTTTTCTTGTGAGGCC	0.333													0	0	0	0.000157383	0	8	32										G	86645051	C	G	86645051	3	3	53	1	0	0	0	0	1	0	0	0	13060	913	32	1	1165	1	RASA1	5	86645051	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		86645051	94270209	44	14680										
FSTL4	23105	broad.mit.edu	37	chr5	132736544	132736544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cccatcagagccgcacacagGcacgtagctgggcctgcatg	12	15	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:132736544G>A	uc003kyn.1	-	4	513	c.295C>T	c.(295-297)CCT>TCT	p.P99S		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	99	Kazal-like.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCGCACACAGGCACGTAGCTG	0.602													0	0	0	0.000175454	0	19	46										A	132736544	G	A	132736544	3	1	53	1	0	0	0	0	1	0	0	0	6079	1203	42	2	2285	2	FSTL4	5	132736544	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	46091493	132736544	48178716	45	14681										
KDM3B	51780	broad.mit.edu	37	chr5	137727502	137727502	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gggaatggccgctccagctcGcccaccagcagcctcactca	10	18	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:137727502G>A	uc003lcy.1	+	8	2381	c.2181G>A	c.(2179-2181)TCG>TCA	p.S727S	KDM3B_uc010jew.1_Silent_p.S383S|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	727	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GCTCCAGCTCGCCCACCAGCA	0.607													0	0	0	0.000442599	0	10	77										A	137727502	G	A	137727502	2	1	53	1	0	0	0	0	0	0	0	1	8127	1074	38	2		2	KDM3B	5	137727502	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	4990958	137727502	43187758	46	14682										
PCDHGA3	56112	broad.mit.edu	37	chr5	140725479	140725479	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gtctgcacacgggcgaggtgCgcacggcgcgagccctgctg	17	14	1	0	rs62378406		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:140725479C>T	uc003ljm.1	+	1	1879	c.1879C>T	c.(1879-1881)CGC>TGC	p.R627C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.R387C|PCDHGA3_uc011dap.1_Missense_Mutation_p.R627C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	627	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGAGGTGCGCACGGCGCG	0.697													0	0	0	0.000229342	0	15	61										T	140725479	C	T	140725479	3	4	53	1	0	0	0	0	1	0	0	0	11555	768	27	2	1881	2	PCDHGA3	5	140725479	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	2997977	140725479	40189781	47	14683										
COL23A1	91522	broad.mit.edu	37	chr5	177673290	177673290	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tcctggcagcccaataaggcCcggtgggccaactggcccct	12	16	0	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr5:177673290C>T	uc003mje.2	-	24	1736	c.1378G>A	c.(1378-1380)GGC>AGC	p.G460S	COL23A1_uc010jkt.2_Missense_Mutation_p.G342S	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	460	Extracellular (Potential).|Collagen-like 4.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		CCAATAAGGCCCGGTGGGCCA	0.557													0	0	0	0.00024832	0	3	6										T	177673290	C	T	177673290	3	4	53	1	0	0	0	0	1	0	0	0	3682	623	22	2	268	2	COL23A1	5	177673290	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	36947811	177673290	3241970	48	14684										
PECI	10455	broad.mit.edu	37	chr6	4117578	4117578	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gcaaatgccttcagcctggtCcagacttctttctgaaaagt	8	11	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:4117578C>T	uc003mwf.2	-	9	1030	c.993G>A	c.(991-993)TGG>TGA	p.W331*	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Nonsense_Mutation_p.W164*|PECI_uc003mwd.2_Nonsense_Mutation_p.W301*|PECI_uc003mwe.2_Nonsense_Mutation_p.W178*|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	331					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TCAGCCTGGTCCAGACTTCTT	0.383													0	0	0	0.000191422	0	34	54										T	4117578	C	T	4117578	4	4	53	1	0	0	0	0	0	1	0	0	11716	856	30	1	199	1	PECI	6	4117578	Nonsense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		4117578	166997489	49	14685										
HIST1H2BF	8343	broad.mit.edu	37	chr6	26200019	26200019	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cgagcgcatcgctggcgaggCttcccgcctggcgcattaca	13	15	0	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:26200019C>G	uc003ngx.2	+	1	233	c.233C>G	c.(232-234)GCT>GGT	p.A78G	HIST1H3D_uc003ngv.2_5'Flank|HIST1H2AD_uc003ngw.2_5'Flank	NM_003522	NP_003513	P62807	H2B1C_HUMAN	histone cluster 1, H2bf	78					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0		all_hematologic(11;0.196)				GCTGGCGAGGCTTCCCGCCTG	0.622													0	0	0	0.00074312	0	17	142										G	26200019	C	G	26200019	3	3	53	1	0	0	0	0	1	0	0	0	7145	797	28	4	235	4	HIST1H2BF	6	26200019	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	22082441	26200019	144915048	50	14686										
BRPF3	27154	broad.mit.edu	37	chr6	36168333	36168333	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	accgaatgcaatagtaacaaGgaaaacagtgaacagcctca	8	9	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:36168333G>A	uc003olv.3	+	2	458	c.234G>A	c.(232-234)AAG>AAA	p.K78K	BRPF3_uc010jwb.2_Silent_p.K78K|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.K78K	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	78					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						ATAGTAACAAGGAAAACAGTG	0.463													0	0	0	0.000673444	0	11	75										A	36168333	G	A	36168333	2	1	53	1	0	0	0	0	0	0	0	1	1521	991	35	2		2	BRPF3	6	36168333	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	9968314	36168333	134946734	51	14687										
C6orf142	90523	broad.mit.edu	37	chr6	54095691	54095691	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	caggagaattctcacaccctCctcagtcacaacgcatgcaa	6	15	3	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:54095691C>T	uc003pcg.3	+	11	1406	c.1293C>T	c.(1291-1293)CTC>CTT	p.L431L	C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Silent_p.L966L	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	431						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CTCACACCCTCCTCAGTCACA	0.463													0	0	0	6.40141e-05	0	12	60										T	54095691	C	T	54095691	2	4	53	1	0	0	0	0	0	0	0	1	2333	842	30	1		1	C6orf142	6	54095691	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	17927358	54095691	117019376	52	14688										
ZNF451	26036	broad.mit.edu	37	chr6	57013396	57013396	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	caagtttactgctagtgcctCacatacagagagaaaactga	8	9	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:57013396C>T	uc003pdm.1	+	10	2737	c.2513C>T	c.(2512-2514)TCA>TTA	p.S838L	ZNF451_uc003pdl.2_Missense_Mutation_p.S838L|ZNF451_uc003pdn.1_Missense_Mutation_p.S838L|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.S838L	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	838					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GCTAGTGCCTCACATACAGAG	0.373													0	0	0	0.000274275	0	8	13										T	57013396	C	T	57013396	3	4	53	1	0	0	0	0	1	0	0	0	17919	838	29	1	2551	1	ZNF451	6	57013396	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	2917705	57013396	114101671	53	14689										
ASCC3	10973	broad.mit.edu	37	chr6	101049784	101049784	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccaccagcaatctctgcattTaagtggtcagagagcactcc	8	13	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:101049784T>G	uc003pqk.2	-	34	5534	c.5205A>C	c.(5203-5205)TTA>TTC	p.L1735F		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1735	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TCTCTGCATTTAAGTGGTCAG	0.368													0	0	0	6.4e-05	0	3	53										G	101049784	T	G	101049784	3	3	53	1	0	0	0	0	1	0	0	0	1033	1751	61	5	1439	5	ASCC3	6	101049784	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	44036388	101049784	70065283	54	14690										
ROS1	6098	broad.mit.edu	37	chr6	117714423	117714423	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccacaattttttgaggtgcaCtaatagagggtggagtaatt	11	5	0	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:117714423C>A	uc003pxp.1	-	11	1425	c.1226G>T	c.(1225-1227)AGT>ATT	p.S409I	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	409	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTGAGGTGCACTAATAGAGGG	0.348			T	GOPC|ROS1	glioblastoma|NSCLC								1	0	7.93312e-07	0.000219431	9.29308e-06	13	239										A	117714423	C	A	117714423	3	1	53	1	0	0	0	0	1	0	0	0	13531	565	20	4	5949	4	ROS1	6	117714423	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	16664639	117714423	53400644	55	14691										
STX11	8676	broad.mit.edu	37	chr6	144508445	144508445	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	atccgcgacgtacacgagctCttcttgcagatggcggtgct	12	12	2	1	rs145774130	byFrequency	TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr6:144508445C>G	uc003qks.3	+	2	873	c.681C>G	c.(679-681)CTC>CTG	p.L227L		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	227	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		TACACGAGCTCTTCTTGCAGA	0.652									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	8.12818e-05	0	7	30										G	144508445	C	G	144508445	2	3	53	1	0	0	0	0	0	0	0	1	15336	900	32	1		1	STX11	6	144508445	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	26794022	144508445	26606622	56	14692										
FIGNL1	63979	broad.mit.edu	37	chr7	50513419	50513419	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	atctaattgaactaaaaattCtgtttttatccttctagaag	4	6	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:50513419C>T	uc003tpc.2	-	4	1944	c.1567G>A	c.(1567-1569)GAA>AAA	p.E523K	FIGNL1_uc003tpb.2_Missense_Mutation_p.E412K|FIGNL1_uc003tpd.2_Missense_Mutation_p.E523K|FIGNL1_uc003tpe.2_Missense_Mutation_p.E523K|FIGNL1_uc010kyy.2_Missense_Mutation_p.E523K	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	523					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				ACTAAAAATTCTGTTTTTATC	0.413													0	0	0	0.000878237	0	29	111										T	50513419	C	T	50513419	3	4	53	1	0	0	0	0	1	0	0	0	5892	922	32	1	461	1	FIGNL1	7	50513419	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		50513419	108625244	57	14693										
TBL2	26608	broad.mit.edu	37	chr7	72988323	72988323	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gtccagctccacgttggctcTcatgctgcggtgctctcgct	11	15	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:72988323T>C	uc003tyh.2	-	3	525	c.391A>G	c.(391-393)AGA>GGA	p.R131G	TBL2_uc011kex.1_Missense_Mutation_p.R95G|TBL2_uc010lbg.2_Missense_Mutation_p.R36G|TBL2_uc003tyi.2_5'UTR|TBL2_uc011key.1_Missense_Mutation_p.R2G|TBL2_uc010lbh.2_Missense_Mutation_p.R36G	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	131											0		Lung NSC(55;0.0659)|all_lung(88;0.152)				ACGTTGGCTCTCATGCTGCGG	0.602													0	0	0	0.000157383	0	8	104										C	72988323	T	C	72988323	3	2	53	1	0	0	0	0	1	0	0	0	15639	1559	54	5	972	5	TBL2	7	72988323	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	22474904	72988323	86150340	58	14694										
SLC25A40	55972	broad.mit.edu	37	chr7	87473129	87473129	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gttggctcatataaaccagaTttctcacataaccacttctt	4	11	3	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:87473129T>C	uc003uje.2	-	9	1032	c.681A>G	c.(679-681)AAA>AAG	p.K227K		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	227					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					ATAAACCAGATTTCTCACATA	0.294													0	0	0	0.000151284	0	12	20										C	87473129	T	C	87473129	2	2	53	1	0	0	0	0	0	0	0	1	14505	1490	52	5		5	SLC25A40	7	87473129	Silent	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	14484806	87473129	71665534	59	14695										
PON2	5445	broad.mit.edu	37	chr7	95041045	95041045	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aatttaaaaatttccactgtAttcttgaattctgggtggtt	7	5	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:95041045A>G	uc003unv.2	-	5	535	c.414T>C	c.(412-414)AAT>AAC	p.N138N	PON2_uc003unu.2_Silent_p.N126N|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Silent_p.N51N	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	138					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			TTTCCACTGTATTCTTGAATT	0.348													0	0	0	3.59834e-05	0	6	32										G	95041045	A	G	95041045	2	3	53	1	0	0	0	0	0	0	0	1	12249	446	16	5		5	PON2	7	95041045	Silent	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	7567916	95041045	64097618	60	14696										
SMURF1	57154	broad.mit.edu	37	chr7	98639810	98639810	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gtagaatactggaagagcccGtaataaggattcagcatttc	10	7	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:98639810G>A	uc003upu.1	-	13	1700	c.1380C>T	c.(1378-1380)TAC>TAT	p.Y460Y	SMURF1_uc003upv.1_Silent_p.Y434Y|SMURF1_uc003upt.2_Silent_p.Y434Y	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	460	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GGAAGAGCCCGTAATAAGGAT	0.388													0	0	0	0.000219431	0	11	120										A	98639810	G	A	98639810	2	1	53	1	0	0	0	0	0	0	0	1	14819	1140	40	2		2	SMURF1	7	98639810	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	3598765	98639810	60498853	61	14697										
RELN	5649	broad.mit.edu	37	chr7	103214705	103214705	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctcaaacctatcgaacatctCattgtgattggggacatttg	8	9	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:103214705C>T	uc003vca.2	-	30	4505	c.4345G>A	c.(4345-4347)GAG>AAG	p.E1449K	RELN_uc010liz.2_Missense_Mutation_p.E1449K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1449					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCGAACATCTCATTGTGATTG	0.458													0	0	0	8.12818e-05	0	6	58										T	103214705	C	T	103214705	3	4	53	1	0	0	0	0	1	0	0	0	13220	835	29	1	6181	1	RELN	7	103214705	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	4574895	103214705	55923958	62	14698										
RELN	5649	broad.mit.edu	37	chr7	103275933	103275933	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tttccaagttatcccattatCataagaataatgcaacaaaa	3	8	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:103275933C>G	uc003vca.2	-	19	2564	c.2404G>C	c.(2404-2406)GAT>CAT	p.D802H	RELN_uc010liz.2_Missense_Mutation_p.D802H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	802	BNR 2.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATCCCATTATCATAAGAATAA	0.438													0	0	0	0.00024832	0	4	69										G	103275933	C	G	103275933	3	3	53	1	0	0	0	0	1	0	0	0	13220	826	29	1	8166	1	RELN	7	103275933	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	61228	103275933	55862730	63	14699										
CPA1	1357	broad.mit.edu	37	chr7	130022031	130022031	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tggcaacacctatgaagggcGtcccatttacgtgctgaagg	12	10	0	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:130022031G>A	uc003vpx.2	+	4	536	c.464G>A	c.(463-465)CGT>CAT	p.R155H	CPA1_uc011kpf.1_Missense_Mutation_p.R67H|CPA1_uc003vpw.2_Intron	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	155					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TATGAAGGGCGTCCCATTTAC	0.552													0	0	0	0.000442599	0	9	100										A	130022031	G	A	130022031	3	1	53	1	0	0	0	0	1	0	0	0	3789	1145	40	2	478	2	CPA1	7	130022031	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	26746098	130022031	29116632	64	14700										
SLC37A3	84255	broad.mit.edu	37	chr7	140058547	140058547	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cagtacagccatttgttgtaGaaacgcagccattctgtgag	10	9	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:140058547G>C	uc003vvo.2	-	6	580	c.414C>G	c.(412-414)TTC>TTG	p.F138L	SLC37A3_uc003vvp.2_Missense_Mutation_p.F138L|SLC37A3_uc010lnh.2_Missense_Mutation_p.F138L|SLC37A3_uc011kqz.1_Intron|SLC37A3_uc011kra.1_Missense_Mutation_p.F138L|SLC37A3_uc011krb.1_Missense_Mutation_p.F110L	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	138					carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					ATTTGTTGTAGAAACGCAGCC	0.507													0	0	0	0.000586117	0	23	228										C	140058547	G	C	140058547	3	2	53	1	0	0	0	0	1	0	0	0	14599	933	33	1	1259	1	SLC37A3	7	140058547	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	10036516	140058547	19080116	65	14701										
KRBA1	84626	broad.mit.edu	37	chr7	149422508	149422508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctgccacccacttcttgttCccagaacccccagccaggag	8	18	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr7:149422508C>T	uc003wfz.2	+	10	1628	c.1229C>T	c.(1228-1230)TCC>TTC	p.S410F	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Missense_Mutation_p.S78F	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	410										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACTTCTTGTTCCCAGAACCCC	0.602													0	0	0	8.12818e-05	0	6	26										T	149422508	C	T	149422508	3	4	53	1	0	0	0	0	1	0	0	0	8439	855	30	1	1263	1	KRBA1	7	149422508	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	9363961	149422508	9716155	66	14702										
XKR6	286046	broad.mit.edu	37	chr8	10755762	10755762	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tccgttacggctctggtgggCgtaacctgggtcccccggta	14	13	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:10755762C>T	uc003wtk.1	-	3	1653	c.1626G>A	c.(1624-1626)ACG>ACA	p.T542T		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	542						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CTCTGGTGGGCGTAACCTGGG	0.637													0	0	0	0.000274275	0	8	38										T	10755762	C	T	10755762	2	4	53	1	0	0	0	0	0	0	0	1	17432	755	27	2		2	XKR6	8	10755762	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		10755762	135608260	67	14703										
DLC1	10395	broad.mit.edu	37	chr8	12947882	12947882	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ggaagtgttggtagtcagctGagtcatcattacccaggtgc	13	8	3	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:12947882G>A	uc003wwm.2	-	15	4397	c.3953C>T	c.(3952-3954)TCA>TTA	p.S1318L	DLC1_uc003wwk.1_Missense_Mutation_p.S881L|DLC1_uc003wwl.1_Missense_Mutation_p.S915L|DLC1_uc011kxx.1_Missense_Mutation_p.S807L	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1318	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GTAGTCAGCTGAGTCATCATT	0.512													0	0	0	0.000673444	0	11	71										A	12947882	G	A	12947882	3	1	53	1	0	0	0	0	1	0	0	0	4550	1294	45	1	649	1	DLC1	8	12947882	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	2192120	12947882	133416140	68	14704										
RIMS2	9699	broad.mit.edu	37	chr8	105160951	105160951	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gaagaatgatggcagccagtCtgacactgcagtgggcacct	13	10	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:105160951C>T	uc003yls.2	+	23	3504	c.3263C>T	c.(3262-3264)TCT>TTT	p.S1088F	RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Missense_Mutation_p.S1077F|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	516					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCAGCCAGTCTGACACTGCA	0.517										HNSCC(12;0.0054)			0	0	0	0.00024832	0	4	16										T	105160951	C	T	105160951	3	4	53	1	0	0	0	0	1	0	0	0	13368	928	32	1		1	RIMS2	8	105160951	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	92213069	105160951	41203071	69	14705										
SYBU	55638	broad.mit.edu	37	chr8	110592172	110592172	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ggtccttttcccgcggggatGatgggctgctgccaggcttg	16	11	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:110592172G>T	uc003ynj.3	-	5	753	c.590C>A	c.(589-591)TCA>TAA	p.S197*	SYBU_uc003yni.3_Nonsense_Mutation_p.S194*|SYBU_uc003ynk.3_Nonsense_Mutation_p.S78*|SYBU_uc010mco.2_Nonsense_Mutation_p.S196*|SYBU_uc003ynl.3_Nonsense_Mutation_p.S196*|SYBU_uc010mcp.2_Nonsense_Mutation_p.S197*|SYBU_uc010mcq.2_Nonsense_Mutation_p.S197*|SYBU_uc003yno.3_Nonsense_Mutation_p.S78*|SYBU_uc010mcr.2_Nonsense_Mutation_p.S197*|SYBU_uc003ynm.3_Nonsense_Mutation_p.S196*|SYBU_uc003ynn.3_Nonsense_Mutation_p.S196*|SYBU_uc010mcs.2_Nonsense_Mutation_p.S78*|SYBU_uc010mct.2_Nonsense_Mutation_p.S197*|SYBU_uc010mcu.2_Nonsense_Mutation_p.S196*|SYBU_uc003ynp.3_Nonsense_Mutation_p.S129*|SYBU_uc010mcv.2_Nonsense_Mutation_p.S197*|SYBU_uc003ynh.3_5'UTR|SYBU_uc011lhw.1_Nonsense_Mutation_p.S67*	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	197	Sufficient for interaction with KIF5B.|Ser-rich.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						CCGCGGGGATGATGGGCTGCT	0.517													1	0	6.44725e-10	0.000295444	7.6475e-09	18	131										T	110592172	G	T	110592172	4	4	53	1	0	0	0	0	0	1	0	0	15424	1294	45	3	1413	3	SYBU	8	110592172	Nonsense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	5431221	110592172	35771850	70	14706										
ENPP2	5168	broad.mit.edu	37	chr8	120577110	120577110	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aagccatcatagtcatagtcGaagattggtccacttatcac	7	10	3	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:120577110G>A	uc003yot.1	-	23	2303	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F	ENPP2_uc011lic.1_Silent_p.F277F|ENPP2_uc003yor.1_Silent_p.F374F|ENPP2_uc003yos.1_Silent_p.F791F|ENPP2_uc010mdd.1_Silent_p.F764F	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	739					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AGTCATAGTCGAAGATTGGTC	0.378													0	0	0	3.59834e-05	0	6	41										A	120577110	G	A	120577110	2	1	53	1	0	0	0	0	0	0	0	1	5130	1049	37	1		1	ENPP2	8	120577110	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	9984938	120577110	25786912	71	14707										
ATAD2	29028	broad.mit.edu	37	chr8	124382178	124382178	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttcatcatcatcatcatcatCatcatcgtcatcatcatcat	1	13	12	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:124382178C>G	uc003yqh.3	-	7	922	c.814G>C	c.(814-816)GAT>CAT	p.D272H	ATAD2_uc011lii.1_Missense_Mutation_p.D63H|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D272H	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	272	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			tcatcatcatcatcatcgtca	0.164													0	0	0	0.000602214	0	5	23										G	124382178	C	G	124382178	3	3	53	1	0	0	0	0	1	0	0	0	1071	826	29	1	3446	1	ATAD2	8	124382178	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	3805068	124382178	21981844	72	14708										
CPSF1	29894	broad.mit.edu	37	chr8	145622615	145622615	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ggaacaccagccgccagtcgGgaagctggtagatctgcagg	15	11	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr8:145622615G>C	uc003zcj.2	-	23	2474	c.2399C>G	c.(2398-2400)CCC>CGC	p.P800R		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	800					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCGCCAGTCGGGAAGCTGGTA	0.647													0	0	0	6.4e-05	0	2	3										C	145622615	G	C	145622615	3	2	53	1	0	0	0	0	1	0	0	0	3824	1232	43	4	1996	4	CPSF1	8	145622615	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	21240437	145622615	741407	73	14709										
TOR2A	27433	broad.mit.edu	37	chr9	130496823	130496823	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	atgctggccggccaggtgctGagccaggtcacactccagac	13	14	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr9:130496823G>A	uc004brs.3	-	2	227	c.172C>T	c.(172-174)CAG>TAG	p.Q58*	TOR2A_uc004brt.3_Nonsense_Mutation_p.Q58*|TOR2A_uc004brw.3_Nonsense_Mutation_p.Q58*|TOR2A_uc011maj.1_Intron|TOR2A_uc004bru.3_Intron|TOR2A_uc004brv.3_Intron|TOR2A_uc004brx.1_5'UTR	NM_001085347	NP_001078816	Q5JU69	TOR2A_HUMAN	torsin family 2, member A isoform a	58					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0						GCCAGGTGCTGAGCCAGGTCA	0.632											OREG0019509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000308642	0	14	26										A	130496823	G	A	130496823	4	1	53	1	0	0	0	0	0	1	0	0	16372	1299	45	1	978	1	TOR2A	9	130496823	Nonsense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		130496823	10716608	74	14710										
ASS1	445	broad.mit.edu	37	chr9	133364826	133364826	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	atcaaacaaggcctgggcttGaaatttgctgagctggtgta	12	7	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr9:133364826G>C	uc004bzm.2	+	13	1301	c.945G>C	c.(943-945)TTG>TTC	p.L315F	ASS1_uc004bzn.2_Missense_Mutation_p.L315F|ASS1_uc010mza.2_Missense_Mutation_p.L391F|ASS1_uc004bzo.2_Missense_Mutation_p.L296F|ASS1_uc010mzb.2_Missense_Mutation_p.L353F|ASS1_uc004bzp.2_Missense_Mutation_p.L315F|ASS1_uc010mzc.2_Missense_Mutation_p.L315F	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	315					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	GCCTGGGCTTGAAATTTGCTG	0.542													0	0	0	0.000375601	0	21	221										C	133364826	G	C	133364826	3	2	53	1	0	0	0	0	1	0	0	0	1061	1281	45	1	987	1	ASS1	9	133364826	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	2868003	133364826	7848605	75	14711										
FAM171A1	221061	broad.mit.edu	37	chr10	15255261	15255261	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctgtctggggctcgaggctCtttctgctggtgctcttgga	15	10	4	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:15255261C>T	uc001iob.2	-	8	2333	c.2326G>A	c.(2326-2328)GAG>AAG	p.E776K		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	776	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GCTCGAGGCTCTTTCTGCTGG	0.577													0	0	0	0.000308642	0	13	64										T	15255261	C	T	15255261	3	4	53	1	0	0	0	0	1	0	0	0	5490	922	32	1	350	1	FAM171A1	10	15255261	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		15255261	120279486	76	14712										
C10orf140	387640	broad.mit.edu	37	chr10	21805233	21805233	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tttgacactactcttgaggtCgggaagtctgccggcatcct	11	11	2	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:21805233C>T	uc009xkd.2	-	4	3772	c.1519G>A	c.(1519-1521)GAC>AAC	p.D507N	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	426						nucleus	nucleotide binding			ovary(1)	1						CTCTTGAGGTCGGGAAGTCTG	0.652													0	0	0	0.000422831	0	17	93										T	21805233	C	T	21805233	3	4	53	1	0	0	0	0	1	0	0	0	1595	884	31	1	1211	1	C10orf140	10	21805233	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	6549972	21805233	113729514	77	14713										
PIP4K2A	5305	broad.mit.edu	37	chr10	22828982	22828982	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tgtcaataattgccatgaagTacacctccttcctaggcgag	8	11	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:22828982T>A	uc001irl.3	-	9	1306	c.1058A>T	c.(1057-1059)TAC>TTC	p.Y353F	PIP4K2A_uc010qcu.1_Missense_Mutation_p.Y213F	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	353	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TGCCATGAAGTACACCTCCTT	0.478													0	0	0	0.000191422	0	37	91										A	22828982	T	A	22828982	3	1	53	1	0	0	0	0	1	0	0	0	11936	1638	57	5	170	5	PIP4K2A	10	22828982	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	1023749	22828982	112705765	78	14714										
CPEB3	22849	broad.mit.edu	37	chr10	93952323	93952323	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctttcagaggttcatgatcaGtccttatcatatccattaag	6	9	4	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr10:93952323G>C	uc001khw.1	-	3	1249	c.1076C>G	c.(1075-1077)ACT>AGT	p.T359S	CPEB3_uc001khu.1_Missense_Mutation_p.T359S|CPEB3_uc001khv.1_Missense_Mutation_p.T359S|CPEB3_uc010qnn.1_Missense_Mutation_p.T359S	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	359							nucleotide binding|RNA binding				0		Colorectal(252;0.0869)				TTCATGATCAGTCCTTATCAT	0.403													0	0	0	3.59834e-05	0	6	19										C	93952323	G	C	93952323	3	2	53	1	0	0	0	0	1	0	0	0	3802	1029	36	4	1079	4	CPEB3	10	93952323	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	71123341	93952323	41582424	79	14715										
RAG2	5897	broad.mit.edu	37	chr11	36615460	36615460	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gatgatgtattgatgcttttCagactccaagctgcctttga	9	8	1	4			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:36615460C>G	uc001mwv.3	-	2	447	c.259G>C	c.(259-261)GAA>CAA	p.E87Q	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	87					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TGATGCTTTTCAGACTCCAAG	0.418									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.000175454	0	20	366										G	36615460	C	G	36615460	3	3	53	1	0	0	0	0	1	0	0	0	13005	835	29	1	1328	1	RAG2	11	36615460	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		36615460	98391056	80	14716										
EXT2	2132	broad.mit.edu	37	chr11	44135765	44135765	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctggtggcggcttttctacGtggacttaccggcaaggcta	14	10	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:44135765G>C	uc001mxz.2	+	4	991	c.657G>C	c.(655-657)ACG>ACC	p.T219T	EXT2_uc010rfo.1_Silent_p.T247T|EXT2_uc001mxy.2_Silent_p.T232T|EXT2_uc009ykt.2_Silent_p.T219T|EXT2_uc001mya.2_Silent_p.T252T	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	219	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GCTTTTCTACGTGGACTTACC	0.473			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				0	0	0	8.12818e-05	0	7	94										C	44135765	G	C	44135765	2	2	53	1	0	0	0	0	0	0	0	1	5324	1132	40	4		4	EXT2	11	44135765	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	7520305	44135765	90870751	81	14717										
OR4A47	403253	broad.mit.edu	37	chr11	48511224	48511224	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tgagaaattctgagatgacaAgtgctatgaagaagctctgg	12	5	2	5			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:48511224A>G	uc010rhx.1	+	1	880	c.880A>G	c.(880-882)AGT>GGT	p.S294G		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGAGATGACAAGTGCTATGAA	0.418													0	0	0	6.4e-05	0	3	56										G	48511224	A	G	48511224	3	3	53	1	0	0	0	0	1	0	0	0	11042	72	3	5	882	5	OR4A47	11	48511224	Missense_Mutation	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	4375459	48511224	86495292	82	14718										
OR8J1	219477	broad.mit.edu	37	chr11	56128191	56128191	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tctatggcttttctacagctAttgtggtttcatcttatgta	7	7	4	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:56128191A>G	uc010rjh.1	+	1	469	c.469A>G	c.(469-471)ATT>GTT	p.I157V		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TTCTACAGCTATTGTGGTTTC	0.423													0	0	0	0.00024832	0	4	36										G	56128191	A	G	56128191	3	3	53	1	0	0	0	0	1	0	0	0	11241	449	16	5	471	5	OR8J1	11	56128191	Missense_Mutation	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	7616967	56128191	78878325	83	14719										
STX3	6809	broad.mit.edu	37	chr11	59554605	59554605	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctctctgcaccgattccagaGccaagtgagtgtttacttag	9	11	1	2	rs140824363		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:59554605G>C	uc001nog.2	+	3	400	c.210G>C	c.(208-210)GAG>GAC	p.E70D	STX3_uc010rkx.1_Missense_Mutation_p.E70D|STX3_uc010rky.1_Intron|STX3_uc009ymt.1_5'UTR	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	70	Cytoplasmic (Potential).|Potential.				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						CGATTCCAGAGCCAAGTGAGT	0.448													0	0	0	8.12818e-05	0	6	43										C	59554605	G	C	59554605	3	2	53	1	0	0	0	0	1	0	0	0	15345	962	34	4	220	4	STX3	11	59554605	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	3426414	59554605	75451911	84	14720										
LTBP3	4054	broad.mit.edu	37	chr11	65308027	65308027	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cactcgtagccaggctgcgtGttcacgcacttgccctcctt	9	16	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:65308027G>A	uc001oej.2	-	22	3305	c.3036C>T	c.(3034-3036)AAC>AAT	p.N1012N	LTBP3_uc001oef.2_Silent_p.N15N|LTBP3_uc001oeg.2_Silent_p.N15N|LTBP3_uc001oeh.2_Silent_p.N442N|LTBP3_uc010roi.1_Silent_p.N895N|LTBP3_uc001oei.2_Silent_p.N1012N|LTBP3_uc010roj.1_Silent_p.N713N|LTBP3_uc010rok.1_Silent_p.N923N	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	1012	EGF-like 10; calcium-binding (Potential).					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CAGGCTGCGTGTTCACGCACT	0.642											OREG0021080	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000295444	0	22	131										A	65308027	G	A	65308027	2	1	53	1	0	0	0	0	0	0	0	1	9075	1368	48	2		2	LTBP3	11	65308027	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	5753422	65308027	69698489	85	14721										
ARHGEF17	9828	broad.mit.edu	37	chr11	73073578	73073578	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cagacgaggaagccgcgacgCtcgcggagccggggccgcag	18	14	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:73073578C>T	uc001otu.2	+	14	4816	c.4795C>T	c.(4795-4797)CTC>TTC	p.L1599F		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1599					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						AGCCGCGACGCTCGCGGAGCC	0.731													0	0	0	8.12818e-05	0	5	32										T	73073578	C	T	73073578	3	4	53	1	0	0	0	0	1	0	0	0	900	797	28	2	4849	2	ARHGEF17	11	73073578	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	7765551	73073578	61932938	86	14722										
HEPHL1	341208	broad.mit.edu	37	chr11	93796804	93796804	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccagccgatgccaactgcctGacctgggtgtaccattcgca	10	15	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:93796804G>C	uc001pep.2	+	3	703	c.546G>C	c.(544-546)CTG>CTC	p.L182L		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	182	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CCAACTGCCTGACCTGGGTGT	0.532													0	0	0	0.000602214	0	5	47										C	93796804	G	C	93796804	2	2	53	1	0	0	0	0	0	0	0	1	7055	1277	45	1		1	HEPHL1	11	93796804	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	20723226	93796804	41209712	87	14723										
SESN3	143686	broad.mit.edu	37	chr11	94911061	94911061	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cagggagaacccatgattttCccaggtatagtcctaaaaga	9	9	0	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:94911061C>T	uc001pfk.1	-	8	1291	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	SESN3_uc010rug.1_Missense_Mutation_p.E218K	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	357					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		CCATGATTTTCCCAGGTATAG	0.313													0	0	0	0.000602214	0	5	15										T	94911061	C	T	94911061	3	4	53	1	0	0	0	0	1	0	0	0	14126	864	30	1	421	1	SESN3	11	94911061	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	1114257	94911061	40095455	88	14724										
DSCAML1	57453	broad.mit.edu	37	chr11	117667803	117667803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	taccagccacatgccataaaGaggccctattctccggggag	10	13	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr11:117667803G>C	uc001prh.1	-	1	174	c.172C>G	c.(172-174)CTT>GTT	p.L58V	DSCAML1_uc001pri.1_Intron	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	Error:Variant_position_missing_in_Q8TD84_after_alignment					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ATGCCATAAAGAGGCCCTATT	0.542													0	0	0	6.4e-05	0	3	50										C	117667803	G	C	117667803	3	2	53	1	0	0	0	0	1	0	0	0	4769	942	33	1	6301	1	DSCAML1	11	117667803	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	22756742	117667803	17338713	89	14725										
NCAPD2	9918	broad.mit.edu	37	chr12	6638150	6638150	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tccttccagatatcatcagcCgcctgtcagaccccgagctg	8	16	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:6638150C>T	uc001qoo.2	+	27	3563	c.3517C>T	c.(3517-3519)CGC>TGC	p.R1173C	NCAPD2_uc010sfd.1_Missense_Mutation_p.R1128C	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1173					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						TATCATCAGCCGCCTGTCAGA	0.517													0	0	0	0.000566183	0	15	81										T	6638150	C	T	6638150	3	4	53	1	0	0	0	0	1	0	0	0	10205	652	23	2	3619	2	NCAPD2	12	6638150	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		6638150	127213745	90	14726										
A2ML1	144568	broad.mit.edu	37	chr12	9020633	9020633	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	acacgttggaggcctcaggcCagggctgtgtctatgtgcag	15	10	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:9020633C>T	uc001quz.3	+	30	4011	c.3913C>T	c.(3913-3915)CAG>TAG	p.Q1305*	A2ML1_uc001qva.1_Nonsense_Mutation_p.Q885*|A2ML1_uc010sgm.1_Nonsense_Mutation_p.Q805*|A2ML1_uc001qvb.1_RNA	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	1149						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGCCTCAGGCCAGGGCTGTGT	0.507													0	0	0	0.000274275	0	8	73										T	9020633	C	T	9020633	4	4	53	1	0	0	0	0	0	1	0	0	5	595	21	2	4031	2	A2ML1	12	9020633	Nonsense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	2382483	9020633	124831262	91	14727										
ITPR2	3709	broad.mit.edu	37	chr12	26818878	26818878	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttgttccctcatcaatttttGacgctctcggtttggcttag	8	10	3	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:26818878G>A	uc001rhg.2	-	14	1933	c.1516C>T	c.(1516-1518)CAA>TAA	p.Q506*		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	506	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ATCAATTTTTGACGCTCTCGG	0.348													0	0	0	0.000442599	0	9	67										A	26818878	G	A	26818878	4	1	53	1	0	0	0	0	0	1	0	0	7921	1299	45	1	6765	1	ITPR2	12	26818878	Nonsense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	17798245	26818878	107033017	92	14728										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100452896	100452896	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aaatggaaagagggaatgagTctacaaaacttattggccgt	11	5	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:100452896T>A	uc001tgq.2	-	14	2388	c.2159A>T	c.(2158-2160)GAC>GTC	p.D720V	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.D370V	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	720										ovary(2)	2						AGGGAATGAGTCTACAAAACT	0.398													0	0	0	8.12818e-05	0	7	65										A	100452896	T	A	100452896	3	1	53	1	0	0	0	0	1	0	0	0	16966	1667	58	5	2267	5	UHRF1BP1L	12	100452896	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	73634018	100452896	33398999	93	14729										
TBX5	6910	broad.mit.edu	37	chr12	114793599	114793599	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gccgagggaccaggggccccGaggtgaagtgagcggagaag	20	9	0	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:114793599G>A	uc001tvo.2	-	9	1790	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	TBX5_uc001tvp.2_Missense_Mutation_p.S432L|TBX5_uc001tvq.2_Missense_Mutation_p.S382L	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	432				MDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQ TS -> WTGYPTSTSPLTSPRGPWSLGWLAWQPWLPTAGRG NVPSTRPP (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CAGGGGCCCCGAGGTGAAGTG	0.647													0	0	0	3.59834e-05	0	5	31										A	114793599	G	A	114793599	3	1	53	1	0	0	0	0	1	0	0	0	15658	1059	37	1	265	1	TBX5	12	114793599	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	14340703	114793599	19058296	94	14730										
GLT1D1	144423	broad.mit.edu	37	chr12	129432001	129432001	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gcatgtcagctgcaattttgGaggtaattatgtaactcgag	11	6	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:129432001G>A	uc010tbh.1	+	11	802	c.793G>A	c.(793-795)GAG>AAG	p.E265K	GLT1D1_uc001uhx.1_Missense_Mutation_p.E180K|GLT1D1_uc001uhy.1_RNA	NM_144669	NP_653270	Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	260					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TGCAATTTTGGAGGTAATTAT	0.458													0	0	0	0.000151284	0	10	65										A	129432001	G	A	129432001	3	1	53	1	0	0	0	0	1	0	0	0	6465	1175	41	1	560	1	GLT1D1	12	129432001	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	14638402	129432001	4419894	95	14731										
EP400	57634	broad.mit.edu	37	chr12	132446281	132446281	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	agcagtgcctggactatcatTaccaggagatgcaggctctg	12	10	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr12:132446281T>C	uc001ujn.2	+	1	1152	c.1117T>C	c.(1117-1119)TAC>CAC	p.Y373H	EP400_uc001ujl.2_Missense_Mutation_p.Y373H|EP400_uc001ujm.2_Missense_Mutation_p.Y373H|EP400_uc001ujj.1_Missense_Mutation_p.Y373H|EP400_uc001ujk.2_Missense_Mutation_p.Y373H	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	373					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGACTATCATTACCAGGAGAT	0.473													0	0	0	0.000157383	0	8	66										C	132446281	T	C	132446281	3	2	53	1	0	0	0	0	1	0	0	0	5149	1754	61	5	1119	5	EP400	12	132446281	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	3014280	132446281	1405614	96	14732										
RASL11A	387496	broad.mit.edu	37	chr13	27845086	27845086	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccccgggacgcgctccatgcGgccgctcagcatgtccgggc	14	18	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:27845086G>C	uc001urd.1	+	1	623	c.5G>C	c.(4-6)CGG>CCG	p.R2P		NM_206827	NP_996563	Q6T310	RSLBA_HUMAN	RAS-like, family 11, member A	2					positive regulation of transcription from RNA polymerase I promoter|small GTPase mediated signal transduction|transcription, DNA-dependent	membrane|nucleolus	GTP binding|GTPase activity			breast(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0173)|GBM - Glioblastoma multiforme(144;0.0557)|OV - Ovarian serous cystadenocarcinoma(117;0.152)|Epithelial(112;0.164)		CGCTCCATGCGGCCGCTCAGC	0.706													0	0	0	6.4e-05	0	2	1										C	27845086	G	C	27845086	3	2	53	1	0	0	0	0	1	0	0	0	13081	1116	39	4	7	4	RASL11A	13	27845086	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		27845086	87324792	97	14733										
CYSLTR2	57105	broad.mit.edu	37	chr13	49281341	49281341	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	acagcagtatttatttcctgAccgtgctgagtgttgtgcgt	11	8	0	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:49281341A>G	uc010acx.1	+	6	1071	c.388A>G	c.(388-390)ACC>GCC	p.T130A	CYSLTR2_uc010acy.1_Missense_Mutation_p.T130A|CYSLTR2_uc010acz.1_Missense_Mutation_p.T130A|CYSLTR2_uc010ada.1_Missense_Mutation_p.T130A|CYSLTR2_uc010adb.1_Missense_Mutation_p.T130A|CYSLTR2_uc010adc.1_Missense_Mutation_p.T130A|CYSLTR2_uc010add.1_Missense_Mutation_p.T130A|CYSLTR2_uc010acw.1_Missense_Mutation_p.T130A|CYSLTR2_uc001vck.2_Missense_Mutation_p.T130A	NM_020377	NP_065110	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	130	Helical; Name=3; (Potential).				immune response	integral to membrane|plasma membrane				lung(2)	2		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TTATTTCCTGACCGTGCTGAG	0.468													0	0	0	6.4e-05	0	3	79										G	49281341	A	G	49281341	3	3	53	1	0	0	0	0	1	0	0	0	4202	275	10	5	390	5	CYSLTR2	13	49281341	Missense_Mutation	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	21436255	49281341	65888537	98	14734										
KLHL1	57626	broad.mit.edu	37	chr13	70681399	70681399	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctccactttgagctcttgcaGaaccagccctttttcgtgtg	8	13	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:70681399G>A	uc001vip.2	-	1	1227	c.433C>T	c.(433-435)CTG>TTG	p.L145L	KLHL1_uc010thm.1_Silent_p.L145L|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	145					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AGCTCTTGCAGAACCAGCCCT	0.557													0	0	0	0.000586117	0	23	122										A	70681399	G	A	70681399	2	1	53	1	0	0	0	0	0	0	0	1	8365	933	33	1		1	KLHL1	13	70681399	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	21400058	70681399	44488479	99	14735										
F10	2159	broad.mit.edu	37	chr13	113795343	113795343	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ggtacaccctggctgacaacGgcaaggcctgcattcccaca	10	15	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr13:113795343G>C	uc001vsx.2	+	5	538	c.481G>C	c.(481-483)GGC>CGC	p.G161R	F10_uc010agq.1_RNA|F10_uc001vsy.2_Missense_Mutation_p.G161R|F10_uc001vsz.2_Missense_Mutation_p.G161R	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	161	EGF-like 2.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTGACAACGGCAAGGCCTG	0.682													0	0	0	0.000602214	0	4	46										C	113795343	G	C	113795343	3	2	53	1	0	0	0	0	1	0	0	0	5336	1116	39	4	499	4	F10	13	113795343	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	43113944	113795343	1374535	100	14736										
TEP1	7011	broad.mit.edu	37	chr14	20876196	20876196	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	caaatcagcttgcgtcatgtGagatatctgtagactctgga	10	8	4	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:20876196G>C	uc001vxe.2	-	2	443	c.403C>G	c.(403-405)CAC>GAC	p.H135D	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.H135D	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	135					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGCGTCATGTGAGATATCTGT	0.527													0	0	0	0.000219431	0	15	168										C	20876196	G	C	20876196	3	2	53	1	0	0	0	0	1	0	0	0	15756	1290	45	1	7696	1	TEP1	14	20876196	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		20876196	86473344	101	14737										
THTPA	79178	broad.mit.edu	37	chr14	24028017	24028017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gctccagagagaggccacagGagactgaagatcctgaccac	12	12	0	6			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:24028017G>A	uc001wkh.3	+	3	1031	c.661G>A	c.(661-663)GAG>AAG	p.E221K	THTPA_uc001wkb.3_RNA|THTPA_uc001wkg.3_Missense_Mutation_p.E221K|THTPA_uc010akr.2_RNA|THTPA_uc001wki.3_3'UTR|uc001wko.1_5'Flank	NM_001126339	NP_001119811	Q9BU02	THTPA_HUMAN	thiamine triphosphatase	221					dephosphorylation|generation of precursor metabolites and energy|thiamine metabolic process	cytosol|nucleolus|soluble fraction	thiamin-triphosphatase activity				0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00643)	Thiamine(DB00152)	GAGGCCACAGGAGACTGAAGA	0.572											OREG0022604	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602214	0	5	46										A	24028017	G	A	24028017	3	1	53	1	0	0	0	0	1	0	0	0	15878	1175	41	1	667	1	THTPA	14	24028017	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	3151821	24028017	83321523	102	14738										
G2E3	55632	broad.mit.edu	37	chr14	31077178	31077178	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tccttcacctggtttcttttCtaaaaccttgtttaactgcc	4	12	3	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:31077178C>G	uc001wqk.2	+	12	1557	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	G2E3_uc010tpe.1_3'UTR|G2E3_uc010tpf.1_Missense_Mutation_p.S422C	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	468	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGTTTCTTTTCTAAAACCTTG	0.378													0	0	0	0.000157383	0	8	39										G	31077178	C	G	31077178	3	3	53	1	0	0	0	0	1	0	0	0	6140	913	32	1	1445	1	G2E3	14	31077178	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	7049161	31077178	76272362	103	14739										
C14orf181	400223	broad.mit.edu	37	chr14	69262546	69262546	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tccaagggtgagggagccgaGaggagggagcgagtccctta	18	8	0	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr14:69262546G>C	uc001xkj.1	-	1	645	c.466C>G	c.(466-468)CTC>GTC	p.L156V	ZFP36L1_uc001xkh.1_5'Flank|ZFP36L1_uc001xki.1_5'Flank	NM_207442	NP_997325			hypothetical protein LOC400223												0				all cancers(60;0.002)|BRCA - Breast invasive adenocarcinoma(234;0.00204)|OV - Ovarian serous cystadenocarcinoma(108;0.0399)		AGGGAGCCGAGAGGAGGGAGC	0.602													0	0	0	6.40141e-05	0	12	107										C	69262546	G	C	69262546	3	2	53	1	0	0	0	0	1	0	0	0	1764	942	33	1	38	1	C14orf181	14	69262546	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	38185368	69262546	38086994	104	14740										
PDIA3	2923	broad.mit.edu	37	chr15	44061801	44061801	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttatgccccttggtgtggtcActgtaagaacctggagccca	11	11	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr15:44061801A>G	uc001zsu.2	+	10	1371	c.1223A>G	c.(1222-1224)CAC>CGC	p.H408R	PDIA3_uc010bdp.2_Missense_Mutation_p.H388R|PDIA3_uc010ued.1_Missense_Mutation_p.H182R	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	408	Thioredoxin 2.	Contributes to redox potential value (By similarity).			cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		TGGTGTGGTCACTGTAAGAAC	0.393													0	0	0	0.00010058	0	11	73										G	44061801	A	G	44061801	3	3	53	1	0	0	0	0	1	0	0	0	11669	159	6	5	1261	5	PDIA3	15	44061801	Missense_Mutation	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08		44061801	58469591	105	14741										
MYEF2	50804	broad.mit.edu	37	chr15	48443319	48443319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	attccagatcctactggaccCatgttagaagatcctattct	6	11	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr15:48443319C>T	uc001zwi.3	-	14	1480	c.1356G>A	c.(1354-1356)ATG>ATA	p.M452I	MYEF2_uc001zwg.3_5'Flank|MYEF2_uc001zwh.3_Intron|MYEF2_uc001zwj.3_Intron	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	452	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		CTACTGGACCCATGTTAGAAG	0.323													0	0	0	0.000602214	0	5	26										T	48443319	C	T	48443319	3	4	53	1	0	0	0	0	1	0	0	0	10024	594	21	2	462	2	MYEF2	15	48443319	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	4381518	48443319	54088073	106	14742										
UNC13C	440279	broad.mit.edu	37	chr15	54586192	54586192	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	catttcaaaaaggagtcagaTgattttctgggacaaacaat	8	6	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr15:54586192T>C	uc002ack.2	+	9	3918	c.3918T>C	c.(3916-3918)GAT>GAC	p.D1306D	UNC13C_uc002acl.2_Silent_p.D136D	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1306	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGGAGTCAGATGATTTTCTGG	0.368													0	0	0	0.000175454	0	19	80										C	54586192	T	C	54586192	2	2	53	1	0	0	0	0	0	0	0	1	16983	1461	51	5		5	UNC13C	15	54586192	Silent	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	6142873	54586192	47945200	107	14743										
HAGH	3029	broad.mit.edu	37	chr16	1859330	1859330	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ccttctccctgcgcacggccCgcatggtggtcaccgggtcc	12	18	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:1859330C>A	uc002cna.2	-	9	1288	c.881G>T	c.(880-882)CGG>CTG	p.R294L	HAGH_uc002cmz.2_Missense_Mutation_p.R246L|HAGH_uc010uvp.1_3'UTR|HAGH_uc002cnb.1_3'UTR	NM_005326	NP_005317	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase isoform 1	294					glutathione biosynthetic process	cytoplasm|mitochondrial matrix|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			ovary(1)	1		Hepatocellular(780;0.00335)			Glutathione(DB00143)	GCGCACGGCCCGCATGGTGGT	0.662													1	0	0.000442599	0.000442599	0.00505904	9	175										A	1859330	C	A	1859330	3	1	53	1	0	0	0	0	1	0	0	0	6945	652	23	4	49	4	HAGH	16	1859330	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		1859330	88495423	108	14744										
TMC7	79905	broad.mit.edu	37	chr16	19058553	19058553	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gcaaccctgaaattcattatCatcttctatgtgaaagaggt	7	8	4	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:19058553C>T	uc002dfq.2	+	12	1852	c.1722C>T	c.(1720-1722)ATC>ATT	p.I574I	TMC7_uc002dfp.2_Silent_p.I574I|TMC7_uc010vap.1_Silent_p.I464I	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	574	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						AATTCATTATCATCTTCTATG	0.368													0	0	0	0.000319135	0	39	314										T	19058553	C	T	19058553	2	4	53	1	0	0	0	0	0	0	0	1	15987	816	29	1		1	TMC7	16	19058553	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	17199223	19058553	71296200	109	14745										
EEF2K	29904	broad.mit.edu	37	chr16	22269882	22269882	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cccccaagtaaggaccctctCtgggagccggccacccctgc	10	19	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:22269882C>T	uc002dki.2	+	10	1582	c.1097C>T	c.(1096-1098)TCT>TTT	p.S366F	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	366					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		AGGACCCTCTCTGGGAGCCGG	0.547													0	0	0	0.000279167	0	30	68										T	22269882	C	T	22269882	3	4	53	1	0	0	0	0	1	0	0	0	4930	913	32	1	1131	1	EEF2K	16	22269882	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	3211329	22269882	68084871	110	14746										
ALDOA	226	broad.mit.edu	37	chr16	30080666	30080666	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tggagcctgagatcctccctGatggggaccatgacttgaag	13	10	0	4			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:30080666G>A	uc002dvw.2	+	9	1708	c.580G>A	c.(580-582)GAT>AAT	p.D194N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ALDOA_uc002dvx.2_Missense_Mutation_p.D194N|ALDOA_uc002dvy.2_Missense_Mutation_p.D194N|ALDOA_uc002dvz.2_Missense_Mutation_p.D194N|ALDOA_uc002dwa.3_Missense_Mutation_p.D194N|ALDOA_uc002dwb.1_Missense_Mutation_p.D194N|ALDOA_uc002dwc.2_Missense_Mutation_p.D194N|ALDOA_uc010veg.1_Missense_Mutation_p.D248N|ALDOA_uc002dwd.2_Missense_Mutation_p.D198N	NM_184043	NP_908932	P04075	ALDOA_HUMAN	fructose-bisphosphate aldolase A	194					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			lung(1)	1						GATCCTCCCTGATGGGGACCA	0.602											OREG0023729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000219431	0	12	88										A	30080666	G	A	30080666	3	1	53	1	0	0	0	0	1	0	0	0	507	1290	45	1	598	1	ALDOA	16	30080666	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	7810784	30080666	60274087	111	14747										
NETO2	81831	broad.mit.edu	37	chr16	47162452	47162452	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttctatataataatgttcatCaaaggtcaactctattcttt	3	7	6	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:47162452C>T	uc002eer.1	-	4	650	c.265G>A	c.(265-267)GAT>AAT	p.D89N	NETO2_uc010vgf.1_5'UTR|NETO2_uc002ees.1_Missense_Mutation_p.D89N	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	89	Extracellular (Potential).|CUB 1.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TAATGTTCATCAAAGGTCAAC	0.358										HNSCC(25;0.065)			0	0	0	0.000566183	0	14	125										T	47162452	C	T	47162452	3	4	53	1	0	0	0	0	1	0	0	0	10340	826	29	1	1336	1	NETO2	16	47162452	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	17081786	47162452	43192301	112	14748										
FHOD1	29109	broad.mit.edu	37	chr16	67263612	67263612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctccgagcccactcttcaacGtccttctcactgcagggaca	7	17	3	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:67263612G>A	uc002esl.2	-	22	3534	c.3422C>T	c.(3421-3423)ACG>ATG	p.T1141M	LRRC29_uc002ese.2_5'Flank|LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|FHOD1_uc002esk.2_Missense_Mutation_p.T200M|FHOD1_uc010ced.2_Missense_Mutation_p.T948M	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1141					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ACTCTTCAACGTCCTTCTCAC	0.582													0	0	0	0.000958276	0	18	108										A	67263612	G	A	67263612	3	1	53	1	0	0	0	0	1	0	0	0	5882	1145	40	2	76	2	FHOD1	16	67263612	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	20101160	67263612	23091141	113	14749										
MBTPS1	8720	broad.mit.edu	37	chr16	84096944	84096944	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctgtcatccaagcaattggaGtccccatacagtacaatccg	7	13	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:84096944G>C	uc002fhi.2	-	19	3040	c.2538C>G	c.(2536-2538)GAC>GAG	p.D846E	MBTPS1_uc002fhh.2_Missense_Mutation_p.D350E	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	846	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						AGCAATTGGAGTCCCCATACA	0.478											OREG0023981	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	3.59834e-05	0	5	140										C	84096944	G	C	84096944	3	2	53	1	0	0	0	0	1	0	0	0	9361	1020	36	4	640	4	MBTPS1	16	84096944	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	16833332	84096944	6257809	114	14750										
BANP	54971	broad.mit.edu	37	chr16	88039762	88039762	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ggccaagaagacagccaccaCgaggacggggagagcggctc	16	12	0	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr16:88039762C>G	uc002fkr.2	+	6	743	c.519C>G	c.(517-519)CAC>CAG	p.H173Q	BANP_uc002fkp.2_Missense_Mutation_p.H143Q|BANP_uc002fkq.2_Missense_Mutation_p.H143Q|BANP_uc010vow.1_Missense_Mutation_p.H181Q|BANP_uc002fks.3_Missense_Mutation_p.H142Q|BANP_uc002fko.1_Missense_Mutation_p.H79Q|BANP_uc010vov.1_Missense_Mutation_p.H148Q	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	174	Interaction with CUX1 and HDAC1 (By similarity).				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		ACAGCCACCACGAGGACGGGG	0.627													0	0	0	0.00074312	0	14	123										G	88039762	C	G	88039762	3	3	53	1	0	0	0	0	1	0	0	0	1310	535	19	4	582	4	BANP	16	88039762	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	3942818	88039762	2314991	115	14751										
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	16	11	1	1	rs121912651		TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.000878237	0	24	79										A	7577539	G	A	7577539	3	1	53	1	0	0	0	0	1	0	0	0	16378	1115	39	2	548	2	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		7577539	73617671	116	14752										
KDM6B	23135	broad.mit.edu	37	chr17	7749991	7749991	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tgtgcctcctgcagcactctCaggcccctcaggggaggagg	14	14	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:7749991C>T	uc002giw.1	+	8	1020	c.644C>T	c.(643-645)TCA>TTA	p.S215L	KDM6B_uc002gix.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	215	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						GCAGCACTCTCAGGCCCCTCA	0.637													0	0	0	0.000308642	0	15	86										T	7749991	C	T	7749991	3	4	53	1	0	0	0	0	1	0	0	0	8138	838	29	1	662	1	KDM6B	17	7749991	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	172452	7749991	73445219	117	14753										
MYH13	8735	broad.mit.edu	37	chr17	10248880	10248880	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttgatgcgggtgaccatccaCaggaacatcttctcgtagac	10	11	2	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:10248880C>A	uc002gmk.1	-	14	1407	c.1317G>T	c.(1315-1317)CTG>CTT	p.L439L	MYH13_uc010vvf.1_Silent_p.L114L	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	439	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGACCATCCACAGGAACATCT	0.517													1	0	1.12685e-05	0.000274275	0.000130383	6	137										A	10248880	C	A	10248880	2	1	53	1	0	0	0	0	0	0	0	1	10032	465	17	4		4	MYH13	17	10248880	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	2498889	10248880	70946330	118	14754										
C17orf48	56985	broad.mit.edu	37	chr17	10614321	10614321	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gtgtataccacgtcaacctaGaaggagttattgaaacagct	9	8	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:10614321G>A	uc002gmt.2	+	4	964	c.889G>A	c.(889-891)GAA>AAA	p.E297K	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	297							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						CGTCAACCTAGAAGGAGTTAT	0.463													0	0	0	0.000274275	0	8	51										A	10614321	G	A	10614321	3	1	53	1	0	0	0	0	1	0	0	0	1859	943	33	1	899	1	C17orf48	17	10614321	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	365441	10614321	70580889	119	14755										
NCOR1	9611	broad.mit.edu	37	chr17	15989705	15989705	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttggtcgagttgtcggaagcCgaacgccttcagggagatta	14	8	1	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:15989705C>G	uc002gpo.2	-	23	3308	c.3068G>C	c.(3067-3069)CGG>CCG	p.R1023P	NCOR1_uc002gpn.2_Missense_Mutation_p.R1039P|NCOR1_uc002gpp.1_Missense_Mutation_p.R930P|NCOR1_uc002gpq.1_Missense_Mutation_p.R115P	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1023	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGTCGGAAGCCGAACGCCTTC	0.458													0	0	0	8.12818e-05	0	7	37										G	15989705	C	G	15989705	3	3	53	1	0	0	0	0	1	0	0	0	10235	652	23	4	4350	4	NCOR1	17	15989705	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	5375384	15989705	65205505	120	14756										
THRA	7067	broad.mit.edu	37	chr17	38244572	38244572	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctgcgggcggctgtccgctaCgaccctgagagcgacaccct	13	16	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:38244572C>T	uc002htw.2	+	8	1284	c.801C>T	c.(799-801)TAC>TAT	p.Y267Y	THRA_uc010cwp.1_Silent_p.Y267Y|THRA_uc002htv.2_Silent_p.Y267Y|THRA_uc002htx.2_Silent_p.Y267Y	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	267	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	CTGTCCGCTACGACCCTGAGA	0.637													0	0	0	0.000219431	0	12	87										T	38244572	C	T	38244572	2	4	53	1	0	0	0	0	0	0	0	1	15870	547	19	2		2	THRA	17	38244572	Silent	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	22254867	38244572	42950638	121	14757										
SMARCE1	6605	broad.mit.edu	37	chr17	38792242	38792247	+	In_Frame_Del	DEL	TGTCTC	TGTCTC	-													0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctcctttctccatgcgagatTgtctctgtcgactttcttcc							TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:38792242_38792247delTGTCTC	uc002hux.2	-	7	601_606	c.477_482delGAGACA	c.(475-483)CAGAGACAA>CAA	p.159_161QRQ>Q	SMARCE1_uc010wff.1_In_Frame_Del_p.124_126QRQ>Q|SMARCE1_uc010wfg.1_In_Frame_Del_p.89_91QRQ>Q|SMARCE1_uc002huy.2_In_Frame_Del_p.124_126QRQ>Q|SMARCE1_uc010wfh.1_In_Frame_Del_p.89_91QRQ>Q|SMARCE1_uc010wfi.1_In_Frame_Del_p.141_143QRQ>Q|SMARCE1_uc002huz.1_In_Frame_Del_p.124_126QRQ>Q|SMARCE1_uc010wfj.1_In_Frame_Del_p.141_143QRQ>Q	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	159_161					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				CATGCGAGATTGTCTCTGTCGACTTT	0.422																		16	99	---	---								-	38792247	TGTCTC	-	38792242	7	5	53	1	0	1	0	1	0	0	0	0	14780	1812	63	0	773	0	SMARCE1	17	38792242	In_Frame_Del	DEL	TGTCTC	TCGA-DK-A2I2-01A-11D-A17V-08	547670	38792242	42402968	122	14758										
NBR1	4077	broad.mit.edu	37	chr17	41331419	41331419	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ttccttttataggtatccatCaacagtcaaggtgagtccct	7	10	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:41331419C>G	uc010czd.2	+	4	314	c.174C>G	c.(172-174)ATC>ATG	p.I58M	NBR1_uc010diz.2_Missense_Mutation_p.I58M|NBR1_uc010whu.1_Missense_Mutation_p.I58M|NBR1_uc010whv.1_Missense_Mutation_p.I58M|NBR1_uc010whw.1_Missense_Mutation_p.I37M	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	58	OPR.				macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		AGGTATCCATCAACAGTCAAG	0.378													0	0	0	0.000602214	0	4	47										G	41331419	C	G	41331419	3	3	53	1	0	0	0	0	1	0	0	0	10200	816	29	1	184	1	NBR1	17	41331419	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	2539177	41331419	39863791	123	14759										
TEX2	55852	broad.mit.edu	37	chr17	62254697	62254697	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	agtgatacctttattttgctGagtttcatttggatcttctt	7	6	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:62254697G>T	uc002jec.2	-	6	2732	c.2559C>A	c.(2557-2559)CTC>CTA	p.L853L	TEX2_uc002jed.2_Silent_p.L860L|TEX2_uc002jee.2_Silent_p.L853L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	853					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TTATTTTGCTGAGTTTCATTT	0.378													1	0	2.12542e-12	0.000147802	2.55321e-11	29	168										T	62254697	G	T	62254697	2	4	53	1	0	0	0	0	0	0	0	1	15778	1277	45	3		3	TEX2	17	62254697	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	20923278	62254697	18940513	124	14760										
SDK2	54549	broad.mit.edu	37	chr17	71394562	71394562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctcctctccctccccaaccaCgcctacctggaaaagggcag	7	19	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:71394562C>T	uc010dfm.2	-	23	3100	c.3100G>A	c.(3100-3102)GTG>ATG	p.V1034M	SDK2_uc002jjt.3_Missense_Mutation_p.V193M|SDK2_uc010dfn.2_Missense_Mutation_p.V713M	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1034	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TCCCCAACCACGCCTACCTGG	0.627													0	0	0	0.000442599	0	10	110										T	71394562	C	T	71394562	3	4	53	1	0	0	0	0	1	0	0	0	13969	536	19	2	3510	2	SDK2	17	71394562	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	9139865	71394562	9800648	125	14761										
RNF213	57674	broad.mit.edu	37	chr17	78319411	78319411	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tgggagaaactggctgtgggAaaaccaggcttattaaattc	12	6	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr17:78319411A>G	uc002jyh.1	+	4	1718	c.1495A>G	c.(1495-1497)AAA>GAA	p.K499E		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGGCTGTGGGAAAACCAGGCT	0.502													0	0	0	0.000586117	0	22	155										G	78319411	A	G	78319411	3	3	53	1	0	0	0	0	1	0	0	0	13477	247	9	5	7705	5	RNF213	17	78319411	Missense_Mutation	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	6924849	78319411	2875799	126	14762										
GALR1	2587	broad.mit.edu	37	chr18	74963033	74963033	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tggcctaccaccagggcctcTtccacccgcgcgccagcaac	9	20	1	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr18:74963033T>C	uc002lms.3	+	1	1026	c.529T>C	c.(529-531)TTC>CTC	p.F177L		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	177	Extracellular (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CCAGGGCCTCTTCCACCCGCG	0.677													0	0	0	0.000132079	0	18	54										C	74963033	T	C	74963033	3	2	53	1	0	0	0	0	1	0	0	0	6227	1609	56	5	531	5	GALR1	18	74963033	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08		74963033	3114215	127	14763										
CD79A	973	broad.mit.edu	37	chr19	42383361	42383361	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	acctacctccgcgtgcgccgTgagtggcccagccctggccc	12	19	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr19:42383361T>G	uc002orv.2	+	2	564	c.379_splice	c.e2+2	p.Q127_splice	CD79A_uc002oru.2_Intron	NM_001783	NP_001774	P11912	CD79A_HUMAN	CD79A antigen isoform 1 precursor						B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			ovary(2)|pancreas(1)	3						GCGTGCGCCGTGAGTGGCCCA	0.592			O|S		DLBCL								0	0	0	0.00010058	0	10	15										G	42383361	T	G	42383361	5	3	53	1	0	0	0	0	0	0	1	0	3036	1710	59	5	387	5	CD79A	19	42383361	Splice_Site	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08		42383361	16745622	128	14764										
ZNF180	7733	broad.mit.edu	37	chr19	44982133	44982134	+	Frame_Shift_Del	DEL	CT	CT	-													0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	agtttcatcacttttgcagaCtctctcatgaataactgctt							TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr19:44982133_44982134delCT	uc002ozf.3	-	5	846_847	c.564_565delAG	c.(562-567)AGAGTCfs	p.R188fs	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Frame_Shift_Del_p.R161fs|ZNF180_uc002ozg.3_Frame_Shift_Del_p.R187fs|ZNF180_uc010ejm.2_Frame_Shift_Del_p.R163fs	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	188_189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CTTTTGCAGACTCTCTCATGAA	0.391																		7	83	---	---								-	44982134	CT	-	44982133	7	5	53	1	0	1	0	1	0	0	0	0	17745	565	20	0	1517	0	ZNF180	19	44982133	Frame_Shift_Del	DEL	CT	TCGA-DK-A2I2-01A-11D-A17V-08	2598772	44982133	14146850	129	14765										
PEG3	5178	broad.mit.edu	37	chr19	57328456	57328456	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cccacactcatcacatacatAtggcattgccccaaaatcaa	3	15	3	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr19:57328456A>G	uc002qnu.2	-	7	1705	c.1354T>C	c.(1354-1356)TAT>CAT	p.Y452H	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Y423H|PEG3_uc002qnv.2_Missense_Mutation_p.Y452H|PEG3_uc002qnw.2_Missense_Mutation_p.Y328H|PEG3_uc002qnx.2_Missense_Mutation_p.Y326H|PEG3_uc010etr.2_Missense_Mutation_p.Y452H	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	452	C2H2-type 1.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCACATACATATGGCATTGCC	0.488													0	0	0	0.000157383	0	6	87										G	57328456	A	G	57328456	3	3	53	1	0	0	0	0	1	0	0	0	11720	449	16	5	3416	5	PEG3	19	57328456	Missense_Mutation	SNP	A	TCGA-DK-A2I2-01A-11D-A17V-08	12346323	57328456	1800527	130	14766										
C20orf26	26074	broad.mit.edu	37	chr20	20279020	20279020	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	acgatgaaaacctgatcacaGatctctataggtgagttgga	10	7	2	4			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr20:20279020G>A	uc002wru.2	+	25	3488	c.3412G>A	c.(3412-3414)GAT>AAT	p.D1138N	C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	1138										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCTGATCACAGATCTCTATAG	0.468													0	0	0	0.000442599	0	8	57										A	20279020	G	A	20279020	3	1	53	1	0	0	0	0	1	0	0	0	2106	942	33	1	3538	1	C20orf26	20	20279020	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		20279020	42746500	131	14767										
ATP9A	10079	broad.mit.edu	37	chr20	50224073	50224073	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cactcatccttaccttgataGatgctaatcaaaacccatat	3	12	2	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr20:50224073G>A	uc002xwg.1	-	26	2796	c.2796C>T	c.(2794-2796)ATC>ATT	p.I932I	ATP9A_uc010gih.1_Silent_p.I796I|ATP9A_uc002xwf.1_Silent_p.I104I	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	932	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						TACCTTGATAGATGCTAATCA	0.488													0	0	0	0.000151284	0	12	39										A	50224073	G	A	50224073	2	1	53	1	0	0	0	0	0	0	0	1	1198	932	33	1		1	ATP9A	20	50224073	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	29945053	50224073	12801447	132	14768										
PTK6	5753	broad.mit.edu	37	chr20	62168507	62168507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	agccctgggccacggccccaCccgcctcgtccagcagcgtg	12	20	0	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr20:62168507C>T	uc002yfg.2	-	1	201	c.161G>A	c.(160-162)GGT>GAT	p.G54D	PTK6_uc011aay.1_Translation_Start_Site|PTK6_uc011aba.1_Missense_Mutation_p.G54D	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	54	SH3.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CACGGCCCCACCCGCCTCGTC	0.692													0	0	0	0.000308642	0	14	18										T	62168507	C	T	62168507	3	4	53	1	0	0	0	0	1	0	0	0	12764	507	18	2	1226	2	PTK6	20	62168507	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	11944434	62168507	857013	133	14769										
MX1	4599	broad.mit.edu	37	chr21	42823170	42823170	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aacctccacagaaccgccaaGgtaaaaccaaccatgtgttg	7	13	0	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr21:42823170G>A	uc002yzh.2	+	17	2456	c.1509G>A	c.(1507-1509)AAG>AAA	p.K503K	MX1_uc002yzi.2_Silent_p.K503K|MX1_uc010goq.2_Silent_p.K503K	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	503					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				GAACCGCCAAGGTAAAACCAA	0.308													0	0	0	0.000781405	0	119	244										A	42823170	G	A	42823170	2	1	53	1	0	0	0	0	0	0	0	1	9997	1014	35	2		2	MX1	21	42823170	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08		42823170	5306725	134	14770										
ITGB2	3689	broad.mit.edu	37	chr21	46306710	46306710	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	cctgtactcccggaggtcgcTcaggtggatcagagccttcc	12	14	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr21:46306710T>C	uc002zgd.2	-	14	2232	c.2188A>G	c.(2188-2190)AGC>GGC	p.S730G	ITGB2_uc002zge.2_Missense_Mutation_p.S730G|ITGB2_uc002zgf.3_Missense_Mutation_p.S730G|ITGB2_uc011afl.1_Missense_Mutation_p.S652G|ITGB2_uc010gpw.2_Missense_Mutation_p.S673G|ITGB2_uc002zgg.2_Missense_Mutation_p.S730G	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	730	Cytoplasmic (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CGGAGGTCGCTCAGGTGGATC	0.627													0	0	0	6.4e-05	0	3	63										C	46306710	T	C	46306710	3	2	53	1	0	0	0	0	1	0	0	0	7894	1551	54	5	129	5	ITGB2	21	46306710	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08	3483540	46306710	1823185	135	14771										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31839041	31839041	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tttctctttgctctcgtacaTcttacgaatcactgaggtag	7	10	4	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chr22:31839041T>C	uc003akz.1	-	16	2277	c.2113A>G	c.(2113-2115)ATG>GTG	p.M705V	EIF4ENIF1_uc003akx.1_Missense_Mutation_p.M360V|EIF4ENIF1_uc003aky.1_Missense_Mutation_p.M385V|EIF4ENIF1_uc003ala.1_Missense_Mutation_p.M705V|EIF4ENIF1_uc003alb.1_Missense_Mutation_p.M531V|EIF4ENIF1_uc003akw.1_Missense_Mutation_p.M195V	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	705						nucleus	protein binding|protein transporter activity			ovary(1)	1						CTCTCGTACATCTTACGAATC	0.458													0	0	0	0.000422831	0	16	49										C	31839041	T	C	31839041	3	2	53	1	0	0	0	0	1	0	0	0	5035	1435	50	5	860	5	EIF4ENIF1	22	31839041	Missense_Mutation	SNP	T	TCGA-DK-A2I2-01A-11D-A17V-08		31839041	19465525	136	14772										
FRMPD4	9758	broad.mit.edu	37	chrX	12736510	12736510	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aggctgatgagagtgtggccCgcctttgtgactaccacttg	13	10	0	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:12736510C>A	uc004cuz.1	+	16	4071	c.3565C>A	c.(3565-3567)CGC>AGC	p.R1189S	FRMPD4_uc011mij.1_Missense_Mutation_p.R1181S	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1189					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						GAGTGTGGCCCGCCTTTGTGA	0.552													1	0	6.36457e-07	0.000586117	7.50224e-06	24	131										A	12736510	C	A	12736510	3	1	53	1	0	0	0	0	1	0	0	0	6059	652	23	4	3627	4	FRMPD4	23	12736510	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08		12736510	142534050	137	14773										
FAM47C	442444	broad.mit.edu	37	chrX	37027156	37027156	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	gagtgtcccatctccgcccaCagcctcccaagactcaggtg	9	17	2	1			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647													0	0	0	0.000602214	0	5	79										G	37027156	C	G	37027156	3	3	53	1	0	0	0	0	1	0	0	0	5571	479	17	4	675	4	FAM47C	23	37027156	Missense_Mutation	SNP	C	TCGA-DK-A2I2-01A-11D-A17V-08	24290646	37027156	118243404	138	14774										
KDM6A	7403	broad.mit.edu	37	chrX	44949018	44949018	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	aatttcctaatgggttcttgGtggcccaatcttgaagatct	9	8	3	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:44949018G>A	uc004dge.3	+	25	3954	c.3579G>A	c.(3577-3579)TGG>TGA	p.W1193*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.W1245*|KDM6A_uc011mla.1_Nonsense_Mutation_p.W1148*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.W1200*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.W897*|KDM6A_uc011mld.1_Nonsense_Mutation_p.W832*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1193	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGGGTTCTTGGTGGCCCAATC	0.353			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.000157383	0	6	16										A	44949018	G	A	44949018	4	1	53	1	0	0	0	0	0	1	0	0	8137	1270	44	2	3677	2	KDM6A	23	44949018	Nonsense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	7921862	44949018	110321542	139	14775										
IGSF1	3547	broad.mit.edu	37	chrX	130411013	130411013	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tcaccaatgcccaccgaaatGattagaaagtgagctgcact	8	11	1	3			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:130411013G>T	uc004ewd.2	-	14	2746	c.2508C>A	c.(2506-2508)ATC>ATA	p.I836I	IGSF1_uc004ewe.3_Silent_p.I830I|IGSF1_uc004ewf.2_Silent_p.I816I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	836	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CCACCGAAATGATTAGAAAGT	0.498													1	0	8.28887e-21	0.000781405	1.0021e-19	52	446										T	130411013	G	T	130411013	2	4	53	1	0	0	0	0	0	0	0	1	7596	1280	45	3		3	IGSF1	23	130411013	Silent	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	85461995	130411013	24859547	140	14776										
FAM58A	92002	broad.mit.edu	37	chrX	152858023	152858023	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	ctcaactccgtagacctgcaGggccaggtagagcaccgcca	11	15	1	2			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:152858023G>C	uc010nug.2	-	3	515	c.412C>G	c.(412-414)CTG>GTG	p.L138V				Q8N1B3	FA58A_HUMAN	RecName: Full=Cyclin-related protein FAM58B;	200					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TAGACCTGCAGGGCCAGGTAG	0.692													0	0	0	8.12818e-05	0	7	31										C	152858023	G	C	152858023	3	2	53	1	0	0	0	0	1	0	0	0	5590	991	35	4	156	4	FAM58A	23	152858023	Missense_Mutation	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	22447010	152858023	2412537	141	14777										
EMD	2010	broad.mit.edu	37	chrX	153609241	153609241	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295774647887324	42	8.55081810719564e-10	2.75036972596781	3.60167464114833	2.36952279022916	0.138719103496437	0.26519828609613	27	tgctcccctcttttgcctcaGggaacgccccatgtacggcc	9	17	2	0			TCGA-DK-A2I2-01A-11D-A17V-08	TCGA-DK-A2I2-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	537e0d59-dd1c-479e-877f-eb9523c0967e	0840ead2-aecf-458d-b042-4b5acda453c8	g.chrX:153609241G>A	uc004fkl.2	+	6	698	c.450_splice	c.e6-1	p.R150_splice		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin						cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTTTGCCTCAGGGAACGCCCC	0.622													0	0	0	0.000219431	0	13	86										A	153609241	G	A	153609241	5	1	53	1	0	0	0	0	0	0	1	0	5087	1014	35	2	471	2	EMD	23	153609241	Splice_Site	SNP	G	TCGA-DK-A2I2-01A-11D-A17V-08	751218	153609241	1661319	142	14778										
FAM132A	388581	broad.mit.edu	37	chr1	1179861	1179861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggcgtcggagaactcaggtCctgaggcctgggatggctga	18	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:1179861C>T	uc001adl.1	-	2	226	c.194G>A	c.(193-195)GGA>GAA	p.G65E		NM_001014980	NP_001014980	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	65						extracellular region					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GAACTCAGGTCCTGAGGCCTG	0.672													0	0	0	0.008871	0	16	81										T	1179861	C	T	1179861	3	4	54	1	0	0	0	0	1	0	0	0	5442	855	30	1	742	1	FAM132A	1	1179861	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08		1179861	248070760	1	14779										
KIAA0495	57212	broad.mit.edu	37	chr1	3662532	3662532	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaggtggccggtggaggcaGatggtgttgcatcctcccgg	17	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:3662532G>A	uc009vlm.2	-	1	1355	c.236C>T	c.(235-237)TCT>TTT	p.S79F	KIAA0495_uc001akt.3_RNA	NM_207306	NP_997189			hypothetical protein LOC57212 precursor												0	all_cancers(77;0.0338)|Ovarian(185;0.0634)|Lung NSC(156;0.172)|all_lung(157;0.182)	all_epithelial(116;1.83e-21)|all_lung(118;2e-08)|Lung NSC(185;7.5e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;1.27e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.204)		GGTGGAGGCAGATGGTGTTGC	0.592													0	0	0	0.00361	0	40	190										A	3662532	G	A	3662532	3	1	54	1	0	0	0	0	1	0	0	0	8180	942	33	1	377	1	KIAA0495	1	3662532	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2482671	3662532	245588089	2	14780										
DFFA	1676	broad.mit.edu	37	chr1	10523212	10523212	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caacgtccgaggaggtctctCtgctgatacccgtgtctact	10	13	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:10523212C>G	uc001arj.2	-	5	784	c.686G>C	c.(685-687)AGA>ACA	p.R229T	DFFA_uc001ark.2_Missense_Mutation_p.R229T	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	229					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GGAGGTCTCTCTGCTGATACC	0.557													0	0	0	0.008291	0	9	66										G	10523212	C	G	10523212	3	3	54	1	0	0	0	0	1	0	0	0	4452	913	32	1	341	1	DFFA	1	10523212	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6860680	10523212	238727409	3	14781										
MFN2	9927	broad.mit.edu	37	chr1	12061571	12061571	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgtctgctaaggaggtgctCaacgccaggattcagaaagc	13	9	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:12061571C>G	uc001atn.3	+	9	1383	c.930C>G	c.(928-930)CTC>CTG	p.L310L	MFN2_uc009vni.2_Silent_p.L310L	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	310	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AGGAGGTGCTCAACGCCAGGA	0.532											OREG0013107	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	7	30										G	12061571	C	G	12061571	2	3	54	1	0	0	0	0	0	0	0	1	9524	813	29	1		1	MFN2	1	12061571	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1538359	12061571	237189050	4	14782										
TNFRSF8	943	broad.mit.edu	37	chr1	12175755	12175755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgctgtgtcccctacccaatCtgtgcagcagagacggtcac	10	15	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:12175755C>G	uc001atq.2	+	8	1137	c.915C>G	c.(913-915)ATC>ATG	p.I305M	TNFRSF8_uc010obc.1_Missense_Mutation_p.I194M	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	305	Extracellular (Potential).|TNFR-Cys 6.				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CCTACCCAATCTGTGCAGCAG	0.627													0	0	0	0.004482	0	9	65										G	12175755	C	G	12175755	3	3	54	1	0	0	0	0	1	0	0	0	16296	903	32	1	945	1	TNFRSF8	1	12175755	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	114184	12175755	237074866	5	14783										
VPS13D	55187	broad.mit.edu	37	chr1	12322040	12322040	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatcatgtctttgccaaactGaatttgcagttgcagcgagg	11	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:12322040G>A	uc001atv.2	+	13	1638	c.1497G>A	c.(1495-1497)CTG>CTA	p.L499L	VPS13D_uc001atw.2_Silent_p.L499L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	499					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTGCCAAACTGAATTTGCAGT	0.448													0	0	0	0.006122	0	14	87										A	12322040	G	A	12322040	2	1	54	1	0	0	0	0	0	0	0	1	17189	1277	45	1		1	VPS13D	1	12322040	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	146285	12322040	236928581	6	14784										
VPS13D	55187	broad.mit.edu	37	chr1	12339681	12339681	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttctagcatcatgaagattGaaggaaaatttgtcaatcca	7	7	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:12339681G>A	uc001atv.2	+	20	4717	c.4576G>A	c.(4576-4578)GAA>AAA	p.E1526K	VPS13D_uc001atw.2_Missense_Mutation_p.E1526K|VPS13D_uc001atx.2_Missense_Mutation_p.E714K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1526					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CATGAAGATTGAAGGAAAATT	0.333													0	0	0	0.008291	0	8	45										A	12339681	G	A	12339681	3	1	54	1	0	0	0	0	1	0	0	0	17189	1291	45	1	4650	1	VPS13D	1	12339681	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	17641	12339681	236910940	7	14785										
KAZ	23254	broad.mit.edu	37	chr1	14925613	14925613	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaccggagactggcggaactGagcggcggcggcggccccgg	19	13	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:14925613G>C	uc001avm.3	+	1	401	c.120G>C	c.(118-120)CTG>CTC	p.L40L	KAZ_uc009vog.1_Silent_p.L40L|KAZ_uc010obj.1_Silent_p.L40L	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	40					keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						TGGCGGAACTGAgcggcggcg	0.468													0	0	0	0.001168	0	6	43										C	14925613	G	C	14925613	2	2	54	1	0	0	0	0	0	0	0	1	7988	1277	45	1		1	KAZ	1	14925613	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2585932	14925613	234325008	8	14786										
RSC1A1	6248	broad.mit.edu	37	chr1	15986462	15986462	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgagtcttgctcgctctgtCtctgcttcagtctgccctat	8	13	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:15986462C>G	uc010obn.1	+	1	99	c.99C>G	c.(97-99)GTC>GTG	p.V33V	DDI2_uc001awx.1_3'UTR|DDI2_uc009voj.1_3'UTR	NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	33					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTCGCTCTGTCTCTGCTTCAG	0.478													0	0	0	0.009718	0	33	183										G	15986462	C	G	15986462	2	3	54	1	0	0	0	0	0	0	0	1	13698	900	32	1		1	RSC1A1	1	15986462	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1060849	15986462	233264159	9	14787			1	58		4	4	980	C		6.945161e-06
RSC1A1	6248	broad.mit.edu	37	chr1	15986581	15986581	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgaaaagaaagaacatctttCtttacaagatctttctgatc	5	7	4	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:15986581C>A	uc010obn.1	+	1	218	c.218C>A	c.(217-219)TCT>TAT	p.S73Y	DDI2_uc001awx.1_3'UTR|DDI2_uc009voj.1_3'UTR	NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	73					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAACATCTTTCTTTACAAGAT	0.428													1	0	9.31168e-06	0.001855	9.66208e-06	11	52										A	15986581	C	A	15986581	3	1	54	1	0	0	0	0	1	0	0	0	13698	913	32	3	220	3	RSC1A1	1	15986581	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	119	15986581	233264040	10	14788			1	58		4	4	980	C		6.945161e-06
RSC1A1	6248	broad.mit.edu	37	chr1	15987253	15987253	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aacatcaaaatgtaacccttCatctgaaattttgaatgatt	4	7	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:15987253C>A	uc010obn.1	+	1	890	c.890C>A	c.(889-891)TCA>TAA	p.S297*		NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	297					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TGTAACCCTTCATCTGAAATT	0.383													1	0	0.000157383	0.00308	0.000161752	6	44										A	15987253	C	A	15987253	4	1	54	1	0	0	0	0	0	1	0	0	13698	838	29	3	892	3	RSC1A1	1	15987253	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	672	15987253	233263368	11	14789			1	58		4	4	980	C		6.945161e-06
RSC1A1	6248	broad.mit.edu	37	chr1	15987441	15987441	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggcagccttgaaagaacttCatgaacttttggttgttagc	10	8	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:15987441C>T	uc010obn.1	+	1	1078	c.1078C>T	c.(1078-1080)CAT>TAT	p.H360Y		NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	360					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAAAGAACTTCATGAACTTTT	0.438													0	0	0	0.008291	0	7	25										T	15987441	C	T	15987441	3	4	54	1	0	0	0	0	1	0	0	0	13698	826	29	1	1080	1	RSC1A1	1	15987441	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	188	15987441	233263180	12	14790			1	58		4	4	980	C		6.945161e-06
PLEKHM2	23207	broad.mit.edu	37	chr1	16053943	16053943	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgactttagtgaggggctttCagccccaatggacttctacc	10	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:16053943C>T	uc010obo.1	+	9	1603	c.1376C>T	c.(1375-1377)TCA>TTA	p.S459L		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	459					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GAGGGGCTTTCAGCCCCAATG	0.632													0	0	0	0.001168	0	4	6										T	16053943	C	T	16053943	3	4	54	1	0	0	0	0	1	0	0	0	12081	838	29	1	1410	1	PLEKHM2	1	16053943	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	66502	16053943	233196678	13	14791										
HTR6	3362	broad.mit.edu	37	chr1	20005075	20005075	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgcaggtgcccaggaccccaCgcccaggggtggagtctgct	15	15	1	0	rs61751019		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:20005075C>A	uc001bcl.2	+	2	1197	c.730C>A	c.(730-732)CGC>AGC	p.R244S		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	244	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CAGGACCCCACGCCCAGGGGT	0.532													1	0	6.21321e-17	0.00278	6.68243e-17	17	126										A	20005075	C	A	20005075	3	1	54	1	0	0	0	0	1	0	0	0	7451	536	19	4	736	4	HTR6	1	20005075	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3951132	20005075	229245546	14	14792										
CDA	978	broad.mit.edu	37	chr1	20944968	20944968	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcaccaactggcccgtgtaCatgaccaagccggatggtac	12	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:20944968C>T	uc001bdk.2	+	4	527	c.348C>T	c.(346-348)TAC>TAT	p.Y116Y	CDA_uc001bdl.2_RNA|CDA_uc009vpv.2_RNA	NM_001785	NP_001776	P32320	CDD_HUMAN	cytidine deaminase	116					cell surface receptor linked signaling pathway|cytosine metabolic process|negative regulation of cell growth|negative regulation of nucleotide metabolic process|protein homotetramerization|pyrimidine nucleoside salvage	cytosol|extracellular region	cytidine deaminase activity|nucleoside binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Lung NSC(340;1.75e-08)|all_lung(284;5.99e-08)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|GBM - Glioblastoma multiforme(114;1.06e-08)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000148)|Kidney(64;0.000184)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.199)	Azacitidine(DB00928)|Capecitabine(DB01101)|Cytarabine(DB00987)|Gemcitabine(DB00441)	GGCCCGTGTACATGACCAAGC	0.373													0	0	0	0.004482	0	5	37										T	20944968	C	T	20944968	2	4	54	1	0	0	0	0	0	0	0	1	3052	489	17	2		2	CDA	1	20944968	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	939893	20944968	228305653	15	14793										
USP48	84196	broad.mit.edu	37	chr1	22074665	22074665	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acgcattagctgcaagttcaGagtgcaaggaaggctaagaa	12	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:22074665G>C	uc001bfb.2	-	7	1112	c.874C>G	c.(874-876)CTG>GTG	p.L292V	USP48_uc010odq.1_Missense_Mutation_p.L292V|USP48_uc009vqc.2_Missense_Mutation_p.L292V|USP48_uc001bfc.2_Missense_Mutation_p.L292V|USP48_uc001bfe.1_Missense_Mutation_p.L292V|USP48_uc001bff.2_Missense_Mutation_p.L292V	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	292					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		TGCAAGTTCAGAGTGCAAGGA	0.378													0	0	0	0.001368	0	9	60										C	22074665	G	C	22074665	3	2	54	1	0	0	0	0	1	0	0	0	17076	933	33	1	2325	1	USP48	1	22074665	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1129697	22074665	227175956	16	14794										
TCEB3	6924	broad.mit.edu	37	chr1	24077712	24077712	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaccaggagcccattgtttCacaccagaagcctgggaaag	12	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:24077712C>T	uc001bho.2	+	4	755	c.695C>T	c.(694-696)TCA>TTA	p.S232L		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	232					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CCCATTGTTTCACACCAGAAG	0.552											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	9	93										T	24077712	C	T	24077712	3	4	54	1	0	0	0	0	1	0	0	0	15678	838	29	1	709	1	TCEB3	1	24077712	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2003047	24077712	225172909	17	14795										
TCEB3	6924	broad.mit.edu	37	chr1	24078045	24078045	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaagaagtgtttgcctccctCagaggccgcttcagacaacc	10	13	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:24078045C>G	uc001bho.2	+	4	1088	c.1028C>G	c.(1027-1029)TCA>TGA	p.S343*		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	343					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TTGCCTCCCTCAGAGGCCGCT	0.522											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	40										G	24078045	C	G	24078045	4	3	54	1	0	0	0	0	0	1	0	0	15678	838	29	1	1042	1	TCEB3	1	24078045	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	333	24078045	225172576	18	14796										
GPN2	54707	broad.mit.edu	37	chr1	27216180	27216180	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccgccctgagacgcaccctGaggtcccactgcgccatttg	10	18	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:27216180G>A	uc001bnd.1	-	1	690	c.408C>T	c.(406-408)CTC>CTT	p.L136L		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	136							GTP binding				0						GACGCACCCTGAGGTCCCACT	0.413													0	0	0	0.005443	0	23	164										A	27216180	G	A	27216180	2	1	54	1	0	0	0	0	0	0	0	1	6618	1277	45	1		1	GPN2	1	27216180	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3138135	27216180	222034441	19	14797										
FGR	2268	broad.mit.edu	37	chr1	27950379	27950379	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccttccaggccagcatcctCcttggccgtggccaccggct	10	19	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:27950379C>A	uc001boj.2	-	1	195	c.49G>T	c.(49-51)GAG>TAG	p.E17*	FGR_uc001bok.2_Nonsense_Mutation_p.E17*|FGR_uc001bol.2_Nonsense_Mutation_p.E17*|FGR_uc001bom.2_Nonsense_Mutation_p.E17*	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	17					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCAGCATCCTCCTTGGCCGTG	0.602													1	0	0.000308642	0.003163	0.000316957	13	72										A	27950379	C	A	27950379	4	1	54	1	0	0	0	0	0	1	0	0	5874	864	30	3	1584	3	FGR	1	27950379	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	734199	27950379	221300242	20	14798										
XKR8	55113	broad.mit.edu	37	chr1	28290051	28290051	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctgctggtgtggcagcagGaggagccctctgagtttgac	17	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:28290051G>C	uc001bph.1	+	2	414	c.337G>C	c.(337-339)GAG>CAG	p.E113Q		NM_018053	NP_060523	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related	113						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		GTGGCAGCAGGAGGAGCCCTC	0.612													0	0	0	0.00499	0	15	103										C	28290051	G	C	28290051	3	2	54	1	0	0	0	0	1	0	0	0	17434	1175	41	1	343	1	XKR8	1	28290051	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	339672	28290051	220960570	21	14799										
EYA3	2140	broad.mit.edu	37	chr1	28365386	28365386	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgaggtataatcattggatGagcgagggatgtaatcggtg	16	3	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:28365386G>T	uc001bpi.1	-	5	353	c.188C>A	c.(187-189)TCA>TAA	p.S63*	EYA3_uc010ofs.1_Nonsense_Mutation_p.S10*|EYA3_uc010oft.1_Nonsense_Mutation_p.S63*|EYA3_uc001bpj.2_Nonsense_Mutation_p.S63*|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	63					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		ATCATTGGATGAGCGAGGGAT	0.318													1	0	9.31168e-06	0.001855	9.66208e-06	8	76										T	28365386	G	T	28365386	4	4	54	1	0	0	0	0	0	1	0	0	5330	1294	45	3	1589	3	EYA3	1	28365386	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	75335	28365386	220885235	22	14800										
GMEB1	10691	broad.mit.edu	37	chr1	29030720	29030720	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagaggacactttgatgttCtggaaaggaatagctgatgt	12	6	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:29030720C>T	uc001bra.2	+	8	915	c.777C>T	c.(775-777)TTC>TTT	p.F259F	GMEB1_uc001bqz.2_Silent_p.F249F|GMEB1_uc001brb.2_Silent_p.F249F	NM_006582	NP_006573	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CTTTGATGTTCTGGAAAGGAA	0.433													0	0	0	0.001168	0	6	109										T	29030720	C	T	29030720	2	4	54	1	0	0	0	0	0	0	0	1	6487	912	32	1		1	GMEB1	1	29030720	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	665334	29030720	220219901	23	14801										
KHDRBS1	10657	broad.mit.edu	37	chr1	32502561	32502561	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttctagagctgtcctacttGaatggagtacctgaaccctc	8	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:32502561G>C	uc001bub.2	+	5	928	c.822G>C	c.(820-822)TTG>TTC	p.L274F	KHDRBS1_uc001bua.1_Missense_Mutation_p.L235F|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	274					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGTCCTACTTGAATGGAGTAC	0.493													0	0	0	0.00333	0	22	150										C	32502561	G	C	32502561	3	2	54	1	0	0	0	0	1	0	0	0	8146	1281	45	1	840	1	KHDRBS1	1	32502561	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3471841	32502561	216748060	24	14802										
TRIM62	55223	broad.mit.edu	37	chr1	33613176	33613176	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacgccactactgaaggcttCagaacccagcaccgacacct	8	16	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:33613176C>A	uc001bxb.2	-	5	1668	c.1030G>T	c.(1030-1032)GAA>TAA	p.E344*		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	344	B30.2/SPRY.					intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)				CTGAAGGCTTCAGAACCCAGC	0.622													1	0	0.00829132	0.008291	0.00844776	7	81										A	33613176	C	A	33613176	4	1	54	1	0	0	0	0	0	1	0	0	16534	835	29	3	401	3	TRIM62	1	33613176	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1110615	33613176	215637445	25	14803										
KIAA0319L	79932	broad.mit.edu	37	chr1	35916018	35916018	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctgactattcccttgtcatCtgaggacttagagccatcca	8	12	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:35916018C>T	uc001byx.2	-	14	2413	c.2155G>A	c.(2155-2157)GAT>AAT	p.D719N	KIAA0319L_uc001byw.2_Missense_Mutation_p.D161N|KIAA0319L_uc010ohv.1_Missense_Mutation_p.D361N	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	719	PKD 5.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCCTTGTCATCTGAGGACTTA	0.512													0	0	0	0.001855	0	13	116										T	35916018	C	T	35916018	3	4	54	1	0	0	0	0	1	0	0	0	8169	913	32	1	1026	1	KIAA0319L	1	35916018	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2302842	35916018	213334603	26	14804										
COL8A2	1296	broad.mit.edu	37	chr1	36564281	36564281	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacccctgtcccccaagagtCctgggaccccagctgggccc	10	20	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:36564281C>G	uc001bzv.1	-	2	1008	c.1001G>C	c.(1000-1002)GGA>GCA	p.G334A	COL8A2_uc001bzw.1_Missense_Mutation_p.G269A	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	334	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCCAAGAGTCCTGGGACCCC	0.721													0	0	0	0.001168	0	4	40										G	36564281	C	G	36564281	3	3	54	1	0	0	0	0	1	0	0	0	3706	855	30	1	1114	1	COL8A2	1	36564281	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	648263	36564281	212686340	27	14805										
COL8A2	1296	broad.mit.edu	37	chr1	36564306	36564306	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaccccagctgggcccctgtCccccttggggcctggcagtc	13	18	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:36564306C>G	uc001bzv.1	-	2	983	c.976G>C	c.(976-978)GAC>CAC	p.D326H	COL8A2_uc001bzw.1_Missense_Mutation_p.D261H	NM_005202	NP_005193	P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2 precursor	326	Triple-helical region.				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGGCCCCTGTCCCCCTTGGGG	0.726													0	0	0	0.000602	0	3	32										G	36564306	C	G	36564306	3	3	54	1	0	0	0	0	1	0	0	0	3706	855	30	1	1139	1	COL8A2	1	36564306	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	25	36564306	212686315	28	14806										
CSF3R	1441	broad.mit.edu	37	chr1	36939118	36939118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcacccagatgcccatattCtggtacaacagcaggtgttt	9	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:36939118C>G	uc001caw.1	-	6	769	c.591G>C	c.(589-591)CAG>CAC	p.Q197H	CSF3R_uc009vvc.1_5'Flank|CSF3R_uc001cau.1_5'Flank|CSF3R_uc001cav.1_Missense_Mutation_p.Q197H|CSF3R_uc001cax.1_Missense_Mutation_p.Q197H|CSF3R_uc001cay.1_Missense_Mutation_p.Q197H	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	197	Fibronectin type-III 1.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGCCCATATTCTGGTACAACA	0.597													0	0	0	0.008361	0	30	164										G	36939118	C	G	36939118	3	3	54	1	0	0	0	0	1	0	0	0	3937	912	32	1	2157	1	CSF3R	1	36939118	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	374812	36939118	212311503	29	14807										
GRIK3	2899	broad.mit.edu	37	chr1	37271815	37271815	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggtggactccatgagcagcGcgtagtcggccgtcagggcc	16	12	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:37271815G>A	uc001caz.2	-	14	2339	c.2204C>T	c.(2203-2205)GCG>GTG	p.A735V	GRIK3_uc001cba.1_Missense_Mutation_p.A735V	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	735	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CATGAGCAGCGCGTAGTCGGC	0.612													0	0	0	0.008871	0	16	170										A	37271815	G	A	37271815	3	1	54	1	0	0	0	0	1	0	0	0	6775	1087	38	2	567	2	GRIK3	1	37271815	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	332697	37271815	211978806	30	14808										
GNL2	29889	broad.mit.edu	37	chr1	38041280	38041280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcaggaatatccgacgcatCaaagtaatatactgccagac	7	10	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:38041280C>T	uc001cbk.2	-	10	1222	c.1059G>A	c.(1057-1059)TTG>TTA	p.L353L		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	353	G.				ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				TCCGACGCATCAAAGTAATAT	0.438													0	0	0	0.001855	0	10	67										T	38041280	C	T	38041280	2	4	54	1	0	0	0	0	0	0	0	1	6536	825	29	1		1	GNL2	1	38041280	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	769465	38041280	211209341	31	14809										
SF3A3	10946	broad.mit.edu	37	chr1	38446330	38446330	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcttcccaaaaagttcattCtgatcttggagaggcttcac	7	10	5	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:38446330C>G	uc001cci.2	-	8	742	c.618G>C	c.(616-618)CAG>CAC	p.Q206H	SF3A3_uc010oik.1_Missense_Mutation_p.Q153H	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3	206					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAAGTTCATTCTGATCTTGGA	0.458													0	0	0	0.006214	0	7	77										G	38446330	C	G	38446330	3	3	54	1	0	0	0	0	1	0	0	0	14148	912	32	1	927	1	SF3A3	1	38446330	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	405050	38446330	210804291	32	14810										
POU3F1	5453	broad.mit.edu	37	chr1	38511339	38511339	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccgagggcttggggcacttGagaaagtggctctcgagcgc	17	10	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:38511339G>C	uc001ccp.1	-	1	1112	c.1077C>G	c.(1075-1077)CTC>CTG	p.L359L		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	359	Homeobox.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGGGGCACTTGAGAAAGTGGC	0.662													0	0	0	0.008291	0	8	37										C	38511339	G	C	38511339	2	2	54	1	0	0	0	0	0	0	0	1	12274	1277	45	1		1	POU3F1	1	38511339	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	65009	38511339	210739282	33	14811										
KIAA0754	643314	broad.mit.edu	37	chr1	39876717	39876717	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttctcaagtgcaacctggccGagggccacaaaaagtttagc	10	11	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:39876717G>A	uc009vvt.1	+	1	1542	c.780G>A	c.(778-780)CCG>CCA	p.P260P	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	124											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAACCTGGCCGAGGGCCACAA	0.522											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	17										A	39876717	G	A	39876717	2	1	54	1	0	0	0	0	0	0	0	1	8192	1045	37	1		1	KIAA0754	1	39876717	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1365378	39876717	209373904	34	14812										
ZNF642	339559	broad.mit.edu	37	chr1	40945004	40945004	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttctggcaatttcctcaccaGaagtggacaagtccagtaag	9	10	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:40945004G>C	uc001cfo.2	+	2	266	c.-28_splice	c.e2-1		ZNF642_uc009vwb.2_5'UTR|ZNF642_uc010ojk.1_Splice_Site	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			TTCCTCACCAGAAGTGGACAA	0.547													0	0	0	0.009718	0	32	162										C	40945004	G	C	40945004	5	2	54	1	0	0	0	0	0	0	1	0	18055	956	33	1		1	ZNF642	1	40945004	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1068287	40945004	208305617	35	14813										
ZNF684	127396	broad.mit.edu	37	chr1	41012608	41012608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaaggcacaccttgcaactCatcagaaaattcataatgga	8	9	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:41012608C>T	uc001cft.1	+	5	864	c.613C>T	c.(613-615)CAT>TAT	p.H205Y		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	205	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			CCTTGCAACTCATCAGAAAAT	0.408													0	0	0	0.004482	0	8	65										T	41012608	C	T	41012608	3	4	54	1	0	0	0	0	1	0	0	0	18088	826	29	1	627	1	ZNF684	1	41012608	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	67604	41012608	208238013	36	14814										
WDR65	149465	broad.mit.edu	37	chr1	43675708	43675708	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctcttatttattcatccatCattcattgaatcaccatcta	1	11	6	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:43675708C>T	uc001cip.1	+	11	2171	c.2050C>T	c.(2050-2052)CAT>TAT	p.H684Y	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Intron|WDR65_uc001ciq.1_Missense_Mutation_p.H684Y	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	Error:Variant_position_missing_in_Q96MR6_after_alignment										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ATTCATCCATCATTCATTGAA	0.279													0	0	0	0.001168	0	5	52										T	43675708	C	T	43675708	3	4	54	1	0	0	0	0	1	0	0	0	17313	826	29	1	2088	1	WDR65	1	43675708	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2663100	43675708	205574913	37	14815										
SLC6A9	6536	broad.mit.edu	37	chr1	44474107	44474107	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctgggcaaggcggctggccGagagccattggtgaggttgg	20	8	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:44474107G>A	uc001cll.2	-	5	919	c.727C>T	c.(727-729)CGG>TGG	p.R243W	SLC6A9_uc009vxe.2_Missense_Mutation_p.R99W|SLC6A9_uc010okm.1_Missense_Mutation_p.R170W|SLC6A9_uc001clm.2_Missense_Mutation_p.R189W|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.R174W|SLC6A9_uc001cln.2_Missense_Mutation_p.R170W|SLC6A9_uc010oko.1_Missense_Mutation_p.R59W|SLC6A9_uc010okp.1_RNA	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	243	Extracellular (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GCGGCTGGCCGAGAGCCATTG	0.642													0	0	0	0.004656	0	20	147										A	44474107	G	A	44474107	3	1	54	1	0	0	0	0	1	0	0	0	14691	1057	37	1	1433	1	SLC6A9	1	44474107	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	798399	44474107	204776514	38	14816										
PTCH2	8643	broad.mit.edu	37	chr1	45293690	45293690	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctcagagcccagtgggtcaGaaggtgggggcaccaggtgg	19	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:45293690G>A	uc010olf.1	-	14	1895	c.1883C>T	c.(1882-1884)TCT>TTT	p.S628F	PTCH2_uc010olg.1_Missense_Mutation_p.S326F	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	628	Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					CAGTGGGTCAGAAGGTGGGGG	0.622									Basal_Cell_Nevus_syndrome				0	0	0	0.002299	0	20	105										A	45293690	G	A	45293690	3	1	54	1	0	0	0	0	1	0	0	0	12731	942	33	1	1784	1	PTCH2	1	45293690	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	819583	45293690	203956931	39	14817										
DMBX1	127343	broad.mit.edu	37	chr1	46972824	46972824	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcatgcgcttacattggctGagcgcctggctggtaagggc	15	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:46972824G>A	uc001cpx.2	+	1	157	c.142G>A	c.(142-144)GAG>AAG	p.E48K	DMBX1_uc001cpw.2_Missense_Mutation_p.E48K	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	48	Interacts with OXT2 and is required for repressor activity (By similarity).				brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TACATTGGCTGAGCGCCTGGC	0.637													0	0	0	0.008291	0	10	40										A	46972824	G	A	46972824	3	1	54	1	0	0	0	0	1	0	0	0	4578	1291	45	1	144	1	DMBX1	1	46972824	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1679134	46972824	202277797	40	14818										
SPATA6	54558	broad.mit.edu	37	chr1	48918750	48918750	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgtattggccaaacacacaGatgctaagatagatgtcctc	8	9	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:48918750G>A	uc001crr.1	-	2	270	c.105C>T	c.(103-105)ATC>ATT	p.I35I	SPATA6_uc001crs.1_Silent_p.I35I|SPATA6_uc010omv.1_Silent_p.I35I|SPATA6_uc001crt.2_5'UTR	NM_019073	NP_061946	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6 precursor	35					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region				ovary(1)	1						CAAACACACAGATGCTAAGAT	0.393													0	0	0	0.010729	0	8	64										A	48918750	G	A	48918750	2	1	54	1	0	0	0	0	0	0	0	1	15012	932	33	1		1	SPATA6	1	48918750	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1945926	48918750	200331871	41	14819										
ZFYVE9	9372	broad.mit.edu	37	chr1	52704969	52704969	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaaaattaggggaaaactCagcaaccaatgtatgcagtc	9	8	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:52704969C>T	uc001cto.2	+	4	2052	c.1880C>T	c.(1879-1881)TCA>TTA	p.S627L	ZFYVE9_uc001ctn.2_Missense_Mutation_p.S627L|ZFYVE9_uc001ctp.2_Missense_Mutation_p.S627L	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	627					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						GGGGAAAACTCAGCAACCAAT	0.358													0	0	0	0.00245	0	12	74										T	52704969	C	T	52704969	3	4	54	1	0	0	0	0	1	0	0	0	17668	838	29	1	1886	1	ZFYVE9	1	52704969	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3786219	52704969	196545652	42	14820										
C1orf175	374977	broad.mit.edu	37	chr1	55119580	55119580	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctctccaccctcatgcatGactctaatcctgggttccaa	5	15	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:55119580G>A	uc010ooe.1	+	3	1305	c.981G>A	c.(979-981)ATG>ATA	p.M327I	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxo.2_Missense_Mutation_p.M327I|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Intron|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.M327I|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	327	Ser-rich.					integral to membrane	binding				0						CCTCATGCATGACTCTAATCC	0.562													0	0	0	0.010504	0	10	167										A	55119580	G	A	55119580	3	1	54	1	0	0	0	0	1	0	0	0	2016	1290	45	1	983	1	C1orf175	1	55119580	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2414611	55119580	194131041	43	14821										
C1orf175	374977	broad.mit.edu	37	chr1	55139782	55139782	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agattggctgtgaggctctgGacggcatcatcatcctctac	11	11	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:55139782G>A	uc010ooe.1	+	10	2218	c.1894G>A	c.(1894-1896)GAC>AAC	p.D632N	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.D200N|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.D150N|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.D632N|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	632						integral to membrane	binding				0						TGAGGCTCTGGACGGCATCAT	0.527													0	0	0	0.012319	0	19	148										A	55139782	G	A	55139782	3	1	54	1	0	0	0	0	1	0	0	0	2016	1174	41	1	1924	1	C1orf175	1	55139782	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	20202	55139782	194110839	44	14822										
TMEM61	199964	broad.mit.edu	37	chr1	55457567	55457567	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgtgagcttcccagtggccGaggggcccccaacaccacct	11	18	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:55457567G>A	uc001cyd.2	+	3	698	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	142						integral to membrane					0						CCCAGTGGCCGAGGGGCCCCC	0.647													0	0	0	0.010504	0	18	139										A	55457567	G	A	55457567	3	1	54	1	0	0	0	0	1	0	0	0	16185	1059	37	1	434	1	TMEM61	1	55457567	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	317785	55457567	193793054	45	14823										
DOCK7	85440	broad.mit.edu	37	chr1	63005436	63005436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcattaccttctgaaatcgtGaaactatatcactagcaatc	4	10	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:63005436G>A	uc001daq.2	-	26	3207	c.3173C>T	c.(3172-3174)TCA>TTA	p.S1058L	DOCK7_uc001dan.2_Missense_Mutation_p.S919L|DOCK7_uc001dao.2_Missense_Mutation_p.S919L|DOCK7_uc001dap.2_Missense_Mutation_p.S1027L|DOCK7_uc001dam.2_Missense_Mutation_p.S238L	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1058					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTGAAATCGTGAAACTATATC	0.343													0	0	0	0.004672	0	3	23										A	63005436	G	A	63005436	3	1	54	1	0	0	0	0	1	0	0	0	4692	1294	45	1	3349	1	DOCK7	1	63005436	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7547869	63005436	186245185	46	14824										
JAK1	3716	broad.mit.edu	37	chr1	65303766	65303766	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcccggtgaacgtattgccGagaacccaaatagtccatcc	9	13	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:65303766G>A	uc001dbu.1	-	22	3238	c.2989C>T	c.(2989-2991)CGG>TGG	p.R997W	JAK1_uc009wam.1_Missense_Mutation_p.R985W|JAK1_uc009wal.1_Missense_Mutation_p.R174W	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	997	Protein kinase 2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		ACGTATTGCCGAGAACCCAAA	0.398			Mis		ALL								0	0	0	0.001984	0	6	45										A	65303766	G	A	65303766	3	1	54	1	0	0	0	0	1	0	0	0	7937	1057	37	1	491	1	JAK1	1	65303766	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2298330	65303766	183946855	47	14825										
WLS	79971	broad.mit.edu	37	chr1	68564388	68564388	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaattcttgataaagttccGaaacaaacaaagcacaatct	4	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:68564388G>A	uc001dee.2	-	12	1830	c.1559C>T	c.(1558-1560)TCG>TTG	p.S520L	uc001deb.1_RNA|uc001dec.1_RNA	NM_001002292	NP_001002292	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 2	Error:Variant_position_missing_in_Q5T9L3_after_alignment					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						ataaagttccgaaacaaacaa	0													0	0	0	0.000602	0	3	44										A	68564388	G	A	68564388	3	1	54	1	0	0	0	0	1	0	0	0	17373	1059	37	1	76	1	WLS	1	68564388	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3260622	68564388	180686233	48	14826										
FUBP1	8880	broad.mit.edu	37	chr1	78444569	78444569	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccgcgcggtccacacttacCtgccgggctctctgcagtgc	12	17	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:78444569C>T	uc001dii.2	-	1	209	c.120G>A	c.(118-120)CAG>CAA	p.Q40Q	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Silent_p.Q40Q|DNAJB4_uc010orn.1_5'Flank	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	40					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CCACACTTACCTGCCGGGCTC	0.498													0	0	0	0.00361	0	47	397										T	78444569	C	T	78444569	2	4	54	1	0	0	0	0	0	0	0	1	6092	695	24	2		2	FUBP1	1	78444569	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	9880181	78444569	170806052	49	14827										
MCOLN3	55283	broad.mit.edu	37	chr1	85498382	85498382	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcctggcccacacttacagtCagagtaaagtcataacagtc	8	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:85498382C>T	uc001dkp.2	-	6	822	c.729G>A	c.(727-729)CTG>CTA	p.L243L	MCOLN3_uc001dkq.2_Silent_p.L187L|MCOLN3_uc001dkr.2_Silent_p.L243L|MCOLN3_uc001dks.3_Silent_p.L88L	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	243						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		CACTTACAGTCAGAGTAAAGT	0.388													0	0	0	0.00361	0	33	252										T	85498382	C	T	85498382	2	4	54	1	0	0	0	0	0	0	0	1	9397	813	29	1		1	MCOLN3	1	85498382	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7053813	85498382	163752239	50	14828										
ABCA4	24	broad.mit.edu	37	chr1	94568588	94568588	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacctgctctggacggacttGagagttgatcagaaggtaga	13	7	2	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:94568588G>C	uc001dqh.2	-	5	657	c.553C>G	c.(553-555)CAA>GAA	p.Q185E	ABCA4_uc010otn.1_Missense_Mutation_p.Q185E	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	185	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGACGGACTTGAGAGTTGATC	0.473													0	0	0	0.003271	0	29	200										C	94568588	G	C	94568588	3	2	54	1	0	0	0	0	1	0	0	0	34	1299	45	1	6452	1	ABCA4	1	94568588	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9070206	94568588	154682033	51	14829										
PTBP2	58155	broad.mit.edu	37	chr1	97278438	97278438	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aacctggatccaaaaattttCaaaacatttttcctccttct	2	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:97278438C>G	uc001drq.2	+	12	1588	c.1342C>G	c.(1342-1344)CAA>GAA	p.Q448E	PTBP2_uc001drn.2_Missense_Mutation_p.Q453E|PTBP2_uc001dro.2_Missense_Mutation_p.Q448E|PTBP2_uc010otz.1_Missense_Mutation_p.Q464E|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.Q396E|PTBP2_uc001drr.2_Missense_Mutation_p.Q453E|PTBP2_uc010oua.1_Missense_Mutation_p.Q456E|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_Missense_Mutation_p.Q67E|PTBP2_uc001drt.2_Missense_Mutation_p.Q67E	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	448							nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CAAAAATTTTCAAAACATTTT	0.358													0	0	0	0.009096	0	3	34										G	97278438	C	G	97278438	3	3	54	1	0	0	0	0	1	0	0	0	12726	827	29	1	1388	1	PTBP2	1	97278438	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2709850	97278438	151972183	52	14830										
PTBP2	58155	broad.mit.edu	37	chr1	97278881	97278881	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caacagtggaagaagctattCaggccttgattgatcttcat	9	8	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:97278881C>G	uc001drq.2	+	14	1762	c.1516C>G	c.(1516-1518)CAG>GAG	p.Q506E	PTBP2_uc001drn.2_Missense_Mutation_p.Q512E|PTBP2_uc001dro.2_Missense_Mutation_p.Q507E|PTBP2_uc010otz.1_Missense_Mutation_p.Q523E|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.Q455E|PTBP2_uc001drr.2_Missense_Mutation_p.Q511E|PTBP2_uc010oua.1_Missense_Mutation_p.Q515E|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_Missense_Mutation_p.Q126E|PTBP2_uc001drt.2_Missense_Mutation_p.Q125E	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	506	RRM 4.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		AGAAGCTATTCAGGCCTTGAT	0.348													0	0	0	0.004482	0	7	47										G	97278881	C	G	97278881	3	3	54	1	0	0	0	0	1	0	0	0	12726	827	29	1	1570	1	PTBP2	1	97278881	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	443	97278881	151971740	53	14831										
DPYD	1806	broad.mit.edu	37	chr1	97839142	97839142	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacaggccaggcccattcctCtttctcccatgccatgtgga	8	16	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:97839142C>T	uc001drv.2	-	16	2170	c.2033G>A	c.(2032-2034)AGA>AAA	p.R678K		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	678	Uracil binding (Potential).				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GCCCATTCCTCTTTCTCCCAT	0.453													0	0	0	0.004482	0	5	58										T	97839142	C	T	97839142	3	4	54	1	0	0	0	0	1	0	0	0	4745	913	32	1	1076	1	DPYD	1	97839142	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	560261	97839142	151411479	54	14832										
CCDC76	54482	broad.mit.edu	37	chr1	100613836	100613836	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgatagtgaagagcatgatGatggaggatacagaatcaca	12	4	1	6			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:100613836G>A	uc001dsv.2	+	10	1223	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	402					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		AGAGCATGATGATGGAGGATA	0.388													0	0	0	0.004656	0	19	140										A	100613836	G	A	100613836	3	1	54	1	0	0	0	0	1	0	0	0	2850	1290	45	1	1242	1	CCDC76	1	100613836	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2774694	100613836	148636785	55	14833										
GPR88	54112	broad.mit.edu	37	chr1	101004982	101004982	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccacctaccaggcgctgtacCagaggcgccacacggcgggc	13	17	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:101004982C>T	uc001dth.2	+	2	864	c.460C>T	c.(460-462)CAG>TAG	p.Q154*		NM_022049	NP_071332	Q9GZN0	GPR88_HUMAN	G-protein coupled receptor 88	154	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		GGCGCTGTACCAGAGGCGCCA	0.756													0	0	0	0.004672	0	3	21										T	101004982	C	T	101004982	4	4	54	1	0	0	0	0	0	1	0	0	6717	595	21	2	462	2	GPR88	1	101004982	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	391146	101004982	148245639	56	14834										
VCAM1	7412	broad.mit.edu	37	chr1	101194797	101194797	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaacccagatagacagccctCtgagcgggaaggtgaggagt	15	9	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:101194797C>G	uc001dti.2	+	5	1183	c.1063C>G	c.(1063-1065)CTG>GTG	p.L355V	VCAM1_uc001dtj.2_Intron|VCAM1_uc010ouj.1_Missense_Mutation_p.L293V	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	355	Ig-like C2-type 4.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGACAGCCCTCTGAGCGGGAA	0.527													0	0	0	0.004482	0	7	49										G	101194797	C	G	101194797	3	3	54	1	0	0	0	0	1	0	0	0	17134	912	32	1	1081	1	VCAM1	1	101194797	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	189815	101194797	148055824	57	14835										
SLC30A7	148867	broad.mit.edu	37	chr1	101361836	101361836	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagatgttgcccctgtccatCaaagacgatgaatacaaacc	7	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:101361836C>G	uc001dtn.2	+	1	205	c.18C>G	c.(16-18)ATC>ATG	p.I6M	EXTL2_uc001dtk.1_5'Flank|EXTL2_uc001dtl.1_5'Flank|EXTL2_uc010ouk.1_5'Flank|EXTL2_uc001dtm.1_5'Flank|SLC30A7_uc001dto.2_Missense_Mutation_p.I6M	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	6	Cytoplasmic (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		CCCTGTCCATCAAAGACGATG	0.587													0	0	0	0.003163	0	12	95										G	101361836	C	G	101361836	3	3	54	1	0	0	0	0	1	0	0	0	14560	816	29	1	20	1	SLC30A7	1	101361836	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	167039	101361836	147888785	58	14836										
S1PR1	1901	broad.mit.edu	37	chr1	101705413	101705413	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagacctgtgacatcctcttCagagcggagtacttcctggt	10	11	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:101705413C>T	uc001dud.2	+	2	1387	c.873C>T	c.(871-873)TTC>TTT	p.F291F	S1PR1_uc009weg.2_Silent_p.F291F	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	291	Extracellular (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						ACATCCTCTTCAGAGCGGAGT	0.552													0	0	0	0.00361	0	54	468										T	101705413	C	T	101705413	2	4	54	1	0	0	0	0	0	0	0	1	13793	825	29	1		1	S1PR1	1	101705413	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	343577	101705413	147545208	59	14837										
AHCYL1	10768	broad.mit.edu	37	chr1	110555027	110555027	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggaaacgtgctcagggggaGaagcccttggctggtgctaa	16	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:110555027G>A	uc001dyx.2	+	4	787	c.420G>A	c.(418-420)GAG>GAA	p.E140E	AHCYL1_uc010ovw.1_Silent_p.E93E|AHCYL1_uc001dyy.2_Silent_p.E93E|AHCYL1_uc010ovx.1_Silent_p.E93E	NM_006621	NP_006612	O43865	SAHH2_HUMAN	S-adenosylhomocysteine hydrolase-like 1	140					one-carbon metabolic process	endoplasmic reticulum	adenosylhomocysteinase activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0259)|Colorectal(144;0.123)|all cancers(265;0.134)|Epithelial(280;0.141)|LUSC - Lung squamous cell carcinoma(189;0.143)		CTCAGGGGGAGAAGCCCTTGG	0.493													0	0	0	0.001368	0	9	76										A	110555027	G	A	110555027	2	1	54	1	0	0	0	0	0	0	0	1	410	933	33	1		1	AHCYL1	1	110555027	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8849614	110555027	138695594	60	14838										
SLC6A17	388662	broad.mit.edu	37	chr1	110716657	110716657	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggagcatcttctatttcttCaagtccttccagtacccgct	6	13	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:110716657C>G	uc009wfq.2	+	4	968	c.507C>G	c.(505-507)TTC>TTG	p.F169L		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	169	Extracellular (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TCTATTTCTTCAAGTCCTTCC	0.577													0	0	0	0.007291	0	27	165										G	110716657	C	G	110716657	3	3	54	1	0	0	0	0	1	0	0	0	14680	825	29	1	517	1	SLC6A17	1	110716657	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	161630	110716657	138533964	61	14839										
WNT2B	7482	broad.mit.edu	37	chr1	113058964	113058964	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtccgttttgccaaggccttCgtggatgccaaggagaagag	14	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:113058964C>T	uc001ecb.2	+	3	1121	c.606C>T	c.(604-606)TTC>TTT	p.F202F	WNT2B_uc001eca.2_Silent_p.F183F|WNT2B_uc009wgg.2_Silent_p.F110F	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	202					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAAGGCCTTCGTGGATGCCA	0.557													0	0	0	0.00245	0	13	108										T	113058964	C	T	113058964	2	4	54	1	0	0	0	0	0	0	0	1	17384	883	31	1		1	WNT2B	1	113058964	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2342307	113058964	136191657	62	14840										
SLC16A1	6566	broad.mit.edu	37	chr1	113464733	113464733	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atacgacttccatatttattCaccaggatactgctgatagg	7	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:113464733C>T	uc001ecx.2	-	3	1072	c.240G>A	c.(238-240)GTG>GTA	p.V80V	SLC16A1_uc001ecy.2_Silent_p.V80V|SLC16A1_uc001ecz.2_Silent_p.V80V|AFARP1_uc001eda.1_5'Flank	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	80	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CATATTTATTCACCAGGATAC	0.403													0	0	0	0.000602	0	5	49										T	113464733	C	T	113464733	2	4	54	1	0	0	0	0	0	0	0	1	14402	813	29	1		1	SLC16A1	1	113464733	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	405769	113464733	135785888	63	14841										
MAGI3	260425	broad.mit.edu	37	chr1	114133225	114133225	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagatgagactctggaaccaCtgcccaaaaactgggaaatg	11	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:114133225C>G	uc001edk.2	+	5	1064	c.883C>G	c.(883-885)CTG>GTG	p.L295V	MAGI3_uc001edh.3_Missense_Mutation_p.L295V|MAGI3_uc001edi.3_Missense_Mutation_p.L295V|MAGI3_uc010owm.1_Missense_Mutation_p.L295V|MAGI3_uc001edj.2_Missense_Mutation_p.L16V	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	295	WW 1.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTGGAACCACTGCCCAAAAA	0.408													0	0	0	0.009096	0	4	40										G	114133225	C	G	114133225	3	3	54	1	0	0	0	0	1	0	0	0	9192	564	20	4	901	4	MAGI3	1	114133225	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	668492	114133225	135117396	64	14842										
HIPK1	204851	broad.mit.edu	37	chr1	114515811	114515811	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accttgccccggcccctgctCacctgccaagccaggctcat	8	20	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:114515811C>T	uc001eem.2	+	16	3471	c.3310C>T	c.(3310-3312)CAC>TAC	p.H1104Y	HIPK1_uc001een.2_Missense_Mutation_p.H1104Y|HIPK1_uc001eeo.2_Missense_Mutation_p.H730Y|HIPK1_uc001eep.2_Missense_Mutation_p.H710Y|HIPK1_uc001eeq.2_Missense_Mutation_p.H396Y	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	1104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCCCCTGCTCACCTGCCAAG	0.627													0	0	0	0.00361	0	43	367										T	114515811	C	T	114515811	3	4	54	1	0	0	0	0	1	0	0	0	7116	826	29	1	3470	1	HIPK1	1	114515811	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	382586	114515811	134734810	65	14843										
SIKE1	80143	broad.mit.edu	37	chr1	115319033	115319033	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccacctgaactgctttcctCatcacttctcccatttcaca	2	17	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:115319033C>T	uc001efo.3	-	4	536	c.456G>A	c.(454-456)ATG>ATA	p.M152I	SIKE1_uc001efp.3_Missense_Mutation_p.M156I	NM_025073	NP_079349	Q9BRV8	SIKE1_HUMAN	suppressor of IKK epsilon isoform 2	152						cytosol	protein binding				0						CTGCTTTCCTCATCACTTCTC	0.363													0	0	0	0.006214	0	8	156										T	115319033	C	T	115319033	3	4	54	1	0	0	0	0	1	0	0	0	14320	826	29	1	175	1	SIKE1	1	115319033	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	803222	115319033	133931588	66	14844										
SIKE1	80143	broad.mit.edu	37	chr1	115319072	115319072	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagattctgtcaatctgactCtcaatttcctgtgaagatat	6	9	4	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:115319072C>G	uc001efo.3	-	4	497	c.417G>C	c.(415-417)GAG>GAC	p.E139D	SIKE1_uc001efp.3_Missense_Mutation_p.E143D	NM_025073	NP_079349	Q9BRV8	SIKE1_HUMAN	suppressor of IKK epsilon isoform 2	139						cytosol	protein binding				0						CAATCTGACTCTCAATTTCCT	0.358													0	0	0	0.00308	0	6	101										G	115319072	C	G	115319072	3	3	54	1	0	0	0	0	1	0	0	0	14320	912	32	1	214	1	SIKE1	1	115319072	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	39	115319072	133931549	67	14845										
ADAM30	11085	broad.mit.edu	37	chr1	120438390	120438390	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccaggaaagtcccttagcctCgccttattctcataaggggc	9	13	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:120438390C>T	uc001eij.2	-	1	724	c.570G>A	c.(568-570)GCG>GCA	p.A190A		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	190					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CCCTTAGCCTCGCCTTATTCT	0.408													0	0	0	0.001168	0	5	74										T	120438390	C	T	120438390	2	4	54	1	0	0	0	0	0	0	0	1	248	871	31	1		1	ADAM30	1	120438390	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5119318	120438390	128812231	68	14846										
NBPF10	100132406	broad.mit.edu	37	chr1	145311808	145311808	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcagcagggagctgctggatGagaaagggcctgaagtcttc	15	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:145311808G>A	uc001end.3	+	14	1911	c.1876G>A	c.(1876-1878)GAG>AAG	p.E626K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_5'UTR|NBPF10_uc010oyl.1_5'UTR|NBPF10_uc010oyj.1_5'UTR	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCTGCTGGATGAGAAAGGGCC	0.483													0	0	0	0.000602	0	4	33										A	145311808	G	A	145311808	3	1	54	1	0	0	0	0	1	0	0	0	10193	1305	45	1		1	NBPF10	1	145311808	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	24873418	145311808	103938813	69	14847										
PEX11B	8799	broad.mit.edu	37	chr1	145522591	145522591	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actgatggagcaagagtcttCtgcttgtagccggcgactga	13	9	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:145522591C>T	uc001eny.1	+	4	470	c.452C>T	c.(451-453)TCT>TTT	p.S151F	NBPF10_uc001emp.3_Intron|PEX11B_uc010oyu.1_Missense_Mutation_p.S137F|ITGA10_uc001enz.1_5'Flank|ITGA10_uc001eoa.2_5'Flank|ITGA10_uc010oyv.1_5'Flank|ITGA10_uc009wiw.2_5'Flank	NM_003846	NP_003837	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	151					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding				0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAAGAGTCTTCTGCTTGTAGC	0.527													0	0	0	0.00245	0	13	88										T	145522591	C	T	145522591	3	4	54	1	0	0	0	0	1	0	0	0	11738	913	32	1	484	1	PEX11B	1	145522591	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	210783	145522591	103728030	70	14848										
RNF115	27246	broad.mit.edu	37	chr1	145682086	145682086	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attcctggatctccacacccTttttcctggtaagtaactaa	5	12	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:145682086T>C	uc001eoj.2	+	5	696	c.492T>C	c.(490-492)CCT>CCC	p.P164P	NBPF10_uc001emp.3_Intron|RNF115_uc001eok.2_Silent_p.P131P|RNF115_uc009wiy.2_Silent_p.P83P	NM_014455	NP_055270	Q9Y4L5	RN115_HUMAN	Rabring 7	164					protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						CTCCACACCCTTTTTCCTGGT	0.358													0	0	0	0.000602	0	3	130										C	145682086	T	C	145682086	2	2	54	1	0	0	0	0	0	0	0	1	13430	1596	56	5		5	RNF115	1	145682086	Silent	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	159495	145682086	103568535	71	14849										
RNF115	27246	broad.mit.edu	37	chr1	145687020	145687020	+	Missense_Mutation	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaaagaagattacacagttGaagaggaagtccggcagtta							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:145687020G>A	uc001eoj.2	+	8	916	c.712G>A	c.(712-714)GAA>AAA	p.E238K	NBPF10_uc001emp.3_Intron|RNF115_uc001eok.2_Missense_Mutation_p.E205K|RNF115_uc009wiy.2_Missense_Mutation_p.E157K	NM_014455	NP_055270	Q9Y4L5	RN115_HUMAN	Rabring 7	238	RING-type.				protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						TTACACAGTTGAAGAGGAAGT	0.413													0	0	0	0.00499	0	13	130										A	145687020	G	A	145687020	3	1	54	1	0	0	0	0	1	0	0	0	13430	1291	45	1	742	1	RNF115	1	145687020	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4934	145687020	103563601	72	14850	71	2								
RNF115	27246	broad.mit.edu	37	chr1	145687023	145687023	+	Missense_Mutation	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagaagattacacagttgaaGaggaagtccggcagttacct							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:145687023G>A	uc001eoj.2	+	8	919	c.715G>A	c.(715-717)GAG>AAG	p.E239K	NBPF10_uc001emp.3_Intron|RNF115_uc001eok.2_Missense_Mutation_p.E206K|RNF115_uc009wiy.2_Missense_Mutation_p.E158K	NM_014455	NP_055270	Q9Y4L5	RN115_HUMAN	Rabring 7	239	RING-type.				protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						CACAGTTGAAGAGGAAGTCCG	0.428													0	0	0	0.004007	0	12	133										A	145687023	G	A	145687023	3	1	54	1	0	0	0	0	1	0	0	0	13430	943	33	1	745	1	RNF115	1	145687023	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3	145687023	103563598	73	14851	71	2								
GPR89B	51463	broad.mit.edu	37	chr1	147400652	147400652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccttccttacacttcgccatGagtttcctgatcgactccag	6	15	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:147400652G>C	uc001epv.3	+	1	147	c.3G>C	c.(1-3)ATG>ATC	p.M1I	GPR89B_uc010ozs.1_Missense_Mutation_p.M1I|GPR89B_uc010ozt.1_5'UTR|GPR89B_uc010ozu.1_5'UTR|GPR89B_uc001epw.3_5'UTR|GPR89B_uc010ozv.1_5'Flank	NM_016334	NP_057418	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89B	1					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(923;0.0276)					ACTTCGCCATGAGTTTCCTGA	0.647													0	0	0	0.001368	0	11	121										C	147400652	G	C	147400652	3	2	54	1	0	0	0	0	1	0	0	0	6719	1290	45	1	5	1	GPR89B	1	147400652	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1713629	147400652	101849969	74	14852										
NBPF14	25832	broad.mit.edu	37	chr1	148009410	148009410	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaggcacttctgtagggctGgcatgagtcagtcagttcaa	12	8	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:148009410G>A	uc001eqq.2	-	16	1914	c.1897C>T	c.(1897-1899)CAG>TAG	p.Q633*	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Nonsense_Mutation_p.Q206*|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	633	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CTGTAGGGCTGGCATGAGTCA	0.478													0	0	0	0.001368	0	8	393										A	148009410	G	A	148009410	4	1	54	1	0	0	0	0	0	1	0	0	10194	1357	47	2	896	2	NBPF14	1	148009410	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	608758	148009410	101241211	75	14853										
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858710	149858710	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcgagtacctgaccgccgaGatcctggagctggcgggcaa	14	13	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:149858710G>T	uc001etd.2	+	1	186	c.186G>T	c.(184-186)GAG>GAT	p.E62D	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	62					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TGACCGCCGAGATCCTGGAGC	0.672													1	0	1.15088e-07	0.004007	1.20577e-07	13	107										T	149858710	G	T	149858710	3	4	54	1	0	0	0	0	1	0	0	0	7178	933	33	3	188	3	HIST2H2AC	1	149858710	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1849300	149858710	99391911	76	14854										
OTUD7B	56957	broad.mit.edu	37	chr1	149921589	149921589	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagtgcagaaaagtgggcctGatcataggcgagcaccagag	15	8	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:149921589G>C	uc001etn.2	-	9	1422	c.1066C>G	c.(1066-1068)CAG>GAG	p.Q356E		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	356	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			AAGTGGGCCTGATCATAGGCG	0.512													0	0	0	0.004482	0	7	91										C	149921589	G	C	149921589	3	2	54	1	0	0	0	0	1	0	0	0	11319	1299	45	1	1481	1	OTUD7B	1	149921589	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	62879	149921589	99329032	77	14855										
OTUD7B	56957	broad.mit.edu	37	chr1	149921612	149921612	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cataggcgagcaccagagggGagcggtgacactggctggct	17	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:149921612G>T	uc001etn.2	-	9	1399	c.1043C>A	c.(1042-1044)TCC>TAC	p.S348Y		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	348	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CACCAGAGGGGAGCGGTGACA	0.512													1	0	4.096e-09	0.001168	4.32634e-09	6	71										T	149921612	G	T	149921612	3	4	54	1	0	0	0	0	1	0	0	0	11319	1174	41	3	1504	3	OTUD7B	1	149921612	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	23	149921612	99329009	78	14856										
ECM1	1893	broad.mit.edu	37	chr1	150483939	150483939	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccctcttgctctagtgggagGaagcaatgagccgattctgt	12	10	3	1	rs149230481		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:150483939G>A	uc001eus.2	+	7	914	c.715G>A	c.(715-717)GAA>AAA	p.E239K	ECM1_uc010pce.1_3'UTR|ECM1_uc010pcf.1_3'UTR|ECM1_uc001eut.2_Intron|ECM1_uc001euu.2_Missense_Mutation_p.E268K|ECM1_uc001euv.2_Missense_Mutation_p.E266K|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	239	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTAGTGGGAGGAAGCAATGAG	0.597													0	0	0	0.005443	0	23	219										A	150483939	G	A	150483939	3	1	54	1	0	0	0	0	1	0	0	0	4897	1175	41	1	741	1	ECM1	1	150483939	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	562327	150483939	98766682	79	14857										
BNIPL	149428	broad.mit.edu	37	chr1	151018574	151018574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacgaaaaatccgttttctgGacagcctgggggagctggcc	13	11	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:151018574G>A	uc001ewl.2	+	9	1143	c.970G>A	c.(970-972)GAC>AAC	p.D324N	BNIPL_uc009wmi.2_Missense_Mutation_p.D242N|BNIPL_uc009wmj.2_RNA|C1orf56_uc001ewn.2_5'Flank	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	324	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCGTTTTCTGGACAGCCTGGG	0.443													0	0	0	0.010729	0	8	61										A	151018574	G	A	151018574	3	1	54	1	0	0	0	0	1	0	0	0	1480	1174	41	1	1004	1	BNIPL	1	151018574	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	534635	151018574	98232047	80	14858										
S100A11	6282	broad.mit.edu	37	chr1	152006245	152006245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caatcagggactcgatgcacCgctcagtctctgtagggctg	12	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152006245C>T	uc001ezn.2	-	2	155	c.35G>A	c.(34-36)CGG>CAG	p.R12Q	uc001ezm.1_Intron	NM_005620	NP_005611	P31949	S10AB_HUMAN	S100 calcium binding protein A11	12					negative regulation of cell proliferation|negative regulation of DNA replication|signal transduction	cytoplasm|nucleus|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding				0	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTCGATGCACCGCTCAGTCTC	0.458													0	0	0	0.004482	0	8	90										T	152006245	C	T	152006245	3	4	54	1	0	0	0	0	1	0	0	0	13773	652	23	2	290	2	S100A11	1	152006245	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	987671	152006245	97244376	81	14859										
HRNR	388697	broad.mit.edu	37	chr1	152193080	152193080	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caaagccagaagtctggcctGagccagactcataatggcca	10	12	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152193080G>C	uc001ezt.1	-	3	1101	c.1025C>G	c.(1024-1026)TCA>TGA	p.S342*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	342	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTCTGGCCTGAGCCAGACTC	0.582													0	0	0	0.00308	0	5	97										C	152193080	G	C	152193080	4	2	54	1	0	0	0	0	0	1	0	0	7359	1294	45	1	7531	1	HRNR	1	152193080	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	186835	152193080	97057541	82	14860										
FLG	2312	broad.mit.edu	37	chr1	152279068	152279068	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttgtgcctgctcatggcggGatccttgtcttcctctagtg	11	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152279068G>C	uc001ezu.1	-	3	8330	c.8294C>G	c.(8293-8295)TCC>TGC	p.S2765C		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2765	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCATGGCGGGATCCTTGTCT	0.577									Ichthyosis				0	0	0	0.011902	0	24	512										C	152279068	G	C	152279068	3	2	54	1	0	0	0	0	1	0	0	0	5922	1174	41	1	3895	1	FLG	1	152279068	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	85988	152279068	96971553	83	14861										
FLG	2312	broad.mit.edu	37	chr1	152279987	152279987	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgtccatgaatggtgtcctGaccctcttgggacgttgagt	13	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152279987G>C	uc001ezu.1	-	3	7411	c.7375C>G	c.(7375-7377)CAG>GAG	p.Q2459E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2459	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTGTCCTGACCCTCTTGG	0.587									Ichthyosis				0	0	0	0.00361	0	82	685										C	152279987	G	C	152279987	3	2	54	1	0	0	0	0	1	0	0	0	5922	1299	45	1	4814	1	FLG	1	152279987	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	919	152279987	96970634	84	14862										
FLG2	388698	broad.mit.edu	37	chr1	152324509	152324509	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtccatgagtagtttggtgtCtcttgtgaactgtggattct	12	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152324509C>T	uc001ezw.3	-	3	5826	c.5753G>A	c.(5752-5754)AGA>AAA	p.R1918K	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1918							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTTTGGTGTCTCTTGTGAAC	0.507													0	0	0	0.006122	0	17	199										T	152324509	C	T	152324509	3	4	54	1	0	0	0	0	1	0	0	0	5923	913	32	1	1426	1	FLG2	1	152324509	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	44522	152324509	96926112	85	14863										
FLG2	388698	broad.mit.edu	37	chr1	152325449	152325449	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaattctggctcttcatgttGagatccggcttggccgtaag	12	9	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152325449G>C	uc001ezw.3	-	3	4886	c.4813C>G	c.(4813-4815)CAA>GAA	p.Q1605E	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1605							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTTCATGTTGAGATCCGGCT	0.512													0	0	0	0.00623	0	34	251										C	152325449	G	C	152325449	3	2	54	1	0	0	0	0	1	0	0	0	5923	1299	45	1	2366	1	FLG2	1	152325449	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	940	152325449	96925172	86	14864										
SPRR4	163778	broad.mit.edu	37	chr1	152944474	152944474	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccctgttaaatgtcaagaGacatgtgcacccaaaaccaa	6	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152944474G>A	uc001fav.1	+	2	171	c.108G>A	c.(106-108)GAG>GAA	p.E36E		NM_173080	NP_775103	Q96PI1	SPRR4_HUMAN	small proline-rich protein 4	36	Gln-rich.				keratinization|peptide cross-linking	cell cortex					0	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AATGTCAAGAGACATGTGCAC	0.498													0	0	0	0.012319	0	18	129										A	152944474	G	A	152944474	2	1	54	1	0	0	0	0	0	0	0	1	15103	933	33	1		1	SPRR4	1	152944474	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	619025	152944474	96306147	87	14865										
SPRR4	163778	broad.mit.edu	37	chr1	152944534	152944534	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcaagaagcaatgcccaccGaaaggcaccatcattccagc	8	14	2	1	rs147360157		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:152944534G>A	uc001fav.1	+	2	231	c.168G>A	c.(166-168)CCG>CCA	p.P56P		NM_173080	NP_775103	Q96PI1	SPRR4_HUMAN	small proline-rich protein 4	56	Gln-rich.				keratinization|peptide cross-linking	cell cortex					0	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AATGCCCACCGAAAGGCACCA	0.522													0	0	0	0.00499	0	15	151										A	152944534	G	A	152944534	2	1	54	1	0	0	0	0	0	0	0	1	15103	1045	37	1		1	SPRR4	1	152944534	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	60	152944534	96306087	88	14866										
KCNN3	3782	broad.mit.edu	37	chr1	154842073	154842073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctggctgccttgcctggagGaagggtggaggatggcggtg	21	7	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:154842073G>A	uc001ffp.2	-	1	682	c.368C>T	c.(367-369)TCC>TTC	p.S123F	KCNN3_uc009wox.1_Missense_Mutation_p.S123F	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	128						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TTGCCTGGAGGAAGGGTGGAG	0.642													0	0	0	0.010729	0	9	99										A	154842073	G	A	154842073	3	1	54	1	0	0	0	0	1	0	0	0	8080	1174	41	1	1881	1	KCNN3	1	154842073	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1897539	154842073	94408548	89	14867										
ZBTB7B	51043	broad.mit.edu	37	chr1	154987446	154987446	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggcactaggcgccctccttGaatttgcctatacagccaca	8	14	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:154987446G>C	uc001fgk.3	+	3	468	c.310G>C	c.(310-312)GAA>CAA	p.E104Q	ZBTB7B_uc009wpa.2_Missense_Mutation_p.E104Q|ZBTB7B_uc001fgj.3_Missense_Mutation_p.E138Q|ZBTB7B_uc010peq.1_Missense_Mutation_p.E138Q|ZBTB7B_uc001fgl.3_Missense_Mutation_p.E104Q	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	104	BTB.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CGCCCTCCTTGAATTTGCCTA	0.647													0	0	0	0.009096	0	4	53										C	154987446	G	C	154987446	3	2	54	1	0	0	0	0	1	0	0	0	17551	1291	45	1	312	1	ZBTB7B	1	154987446	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	145373	154987446	94263175	90	14868										
ZBTB7B	51043	broad.mit.edu	37	chr1	154988052	154988052	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccagaggagctgggctcaGatgaggatgccatcgatcct	13	12	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:154988052G>C	uc001fgk.3	+	3	1074	c.916G>C	c.(916-918)GAT>CAT	p.D306H	ZBTB7B_uc009wpa.2_Missense_Mutation_p.D306H|ZBTB7B_uc001fgj.3_Missense_Mutation_p.D340H|ZBTB7B_uc010peq.1_Missense_Mutation_p.D340H|ZBTB7B_uc001fgl.3_Missense_Mutation_p.D306H	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	306					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTGGGCTCAGATGAGGATGC	0.622													0	0	0	0.004482	0	7	85										C	154988052	G	C	154988052	3	2	54	1	0	0	0	0	1	0	0	0	17551	942	33	1	918	1	ZBTB7B	1	154988052	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	606	154988052	94262569	91	14869										
RUSC1	23623	broad.mit.edu	37	chr1	155292224	155292224	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggcggatgatgggaaaatCgacgctgggaaaacggagcc	17	7	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:155292224C>T	uc001fkj.2	+	2	889	c.660C>T	c.(658-660)ATC>ATT	p.I220I	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Silent_p.I220I|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	220						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			ATGGGAAAATCGACGCTGGGA	0.502													0	0	0	0.00308	0	6	61										T	155292224	C	T	155292224	2	4	54	1	0	0	0	0	0	0	0	1	13750	874	31	1		1	RUSC1	1	155292224	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	304172	155292224	93958397	92	14870										
ASH1L	55870	broad.mit.edu	37	chr1	155450002	155450002	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggcctgcctctcttttttgGaaaaggagacacagacagac	10	10	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:155450002G>C	uc009wqq.2	-	3	3139	c.2659C>G	c.(2659-2661)CCA>GCA	p.P887A	ASH1L_uc001fkt.2_Missense_Mutation_p.P887A|ASH1L_uc009wqr.1_Missense_Mutation_p.P887A	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	887	A.T hook 1.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTCTTTTTTGGAAAAGGAGAC	0.443													0	0	0	0.006214	0	6	69										C	155450002	G	C	155450002	3	2	54	1	0	0	0	0	1	0	0	0	1041	1174	41	1	6339	1	ASH1L	1	155450002	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	157778	155450002	93800619	93	14871										
ASH1L	55870	broad.mit.edu	37	chr1	155450149	155450149	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttaggtggcccttccagttGaggcatctccttagatttag	10	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:155450149G>C	uc009wqq.2	-	3	2992	c.2512C>G	c.(2512-2514)CAA>GAA	p.Q838E	ASH1L_uc001fkt.2_Missense_Mutation_p.Q838E|ASH1L_uc009wqr.1_Missense_Mutation_p.Q838E	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	838					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CCTTCCAGTTGAGGCATCTCC	0.408													0	0	0	0.000602	0	4	49										C	155450149	G	C	155450149	3	2	54	1	0	0	0	0	1	0	0	0	1041	1299	45	1	6486	1	ASH1L	1	155450149	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	147	155450149	93800472	94	14872										
YY1AP1	55249	broad.mit.edu	37	chr1	155631206	155631206	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actggcagctgtttggtcttCttataaaacttaacatgaaa	7	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:155631206C>T	uc001fln.2	-	10	1050	c.1026G>A	c.(1024-1026)AAG>AAA	p.K342K	YY1AP1_uc001flg.2_Silent_p.K81K|YY1AP1_uc010pgg.1_Silent_p.K181K|YY1AP1_uc010pgh.1_Silent_p.K285K|YY1AP1_uc010pgi.1_Silent_p.K434K|YY1AP1_uc001flh.2_Silent_p.K414K|YY1AP1_uc009wqt.2_Silent_p.K265K|YY1AP1_uc001flk.2_Silent_p.K285K|YY1AP1_uc001fll.2_Silent_p.K296K|YY1AP1_uc009wqv.2_Silent_p.K13K|YY1AP1_uc001flm.2_Silent_p.K285K|YY1AP1_uc001fli.2_Silent_p.K296K|YY1AP1_uc009wqu.2_Silent_p.K129K|YY1AP1_uc001flj.2_Silent_p.K276K|YY1AP1_uc009wqw.2_Silent_p.K265K|YY1AP1_uc001flo.2_Silent_p.K230K|YY1AP1_uc001flp.2_Silent_p.K296K|YY1AP1_uc010pgj.1_Silent_p.K362K|YY1AP1_uc009wqx.2_Silent_p.K434K	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	342					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GTTTGGTCTTCTTATAAAACT	0.453													0	0	0	0.003163	0	6	71										T	155631206	C	T	155631206	2	4	54	1	0	0	0	0	0	0	0	1	17505	912	32	1		1	YY1AP1	1	155631206	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	181057	155631206	93619415	95	14873										
GON4L	54856	broad.mit.edu	37	chr1	155774800	155774800	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catcttccagtcctcatcatCtgccgtattggggtcataca	7	13	5	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:155774800C>G	uc001flz.2	-	11	1682	c.1585G>C	c.(1585-1587)GAT>CAT	p.D529H	GON4L_uc001fly.1_Missense_Mutation_p.D529H|GON4L_uc009wrh.1_Missense_Mutation_p.D529H|GON4L_uc001fma.1_Missense_Mutation_p.D529H|GON4L_uc001fmc.2_Missense_Mutation_p.D529H|GON4L_uc001fmd.3_Missense_Mutation_p.D529H|GON4L_uc009wri.2_Missense_Mutation_p.D115H|GON4L_uc009wrj.1_Missense_Mutation_p.D44H|GON4L_uc001fme.2_Missense_Mutation_p.D357H|GON4L_uc001fmf.2_Missense_Mutation_p.D223H	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	529	Asp-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCCTCATCATCTGCCGTATTG	0.463													0	0	0	0.007291	0	23	222										G	155774800	C	G	155774800	3	3	54	1	0	0	0	0	1	0	0	0	6572	913	32	1	5342	1	GON4L	1	155774800	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	143594	155774800	93475821	96	14874										
MEF2D	4209	broad.mit.edu	37	chr1	156438787	156438787	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctaaaggctggtaaggaggaGagctctgcactggtcaactg	14	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:156438787G>A	uc001fpc.2	-	10	1422	c.1032C>T	c.(1030-1032)CTC>CTT	p.L344L	MEF2D_uc001fpb.2_Silent_p.L337L|MEF2D_uc001fpd.2_Silent_p.L337L|MEF2D_uc001fpe.1_Silent_p.L344L|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	344					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTAAGGAGGAGAGCTCTGCAC	0.448													0	0	0	0.007413	0	13	91										A	156438787	G	A	156438787	2	1	54	1	0	0	0	0	0	0	0	1	9458	929	33	1		1	MEF2D	1	156438787	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	663987	156438787	92811834	97	14875										
GPATCH4	54865	broad.mit.edu	37	chr1	156565223	156565223	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacccccatcttctcctcttCatggtgccacctcttctttt	4	17	6	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:156565223C>T	uc001fpm.2	-	8	949	c.910G>A	c.(910-912)GAA>AAA	p.E304K	APOA1BP_uc010php.1_Intron|GPATCH4_uc001fpl.2_Missense_Mutation_p.E299K	NM_015590	NP_056405	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4 isoform 1	299						intracellular	nucleic acid binding			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTCTCCTCTTCATGGTGCCAC	0.542													0	0	0	0.010818	0	29	196										T	156565223	C	T	156565223	3	4	54	1	0	0	0	0	1	0	0	0	6593	835	29	1	221	1	GPATCH4	1	156565223	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	126436	156565223	92685398	98	14876										
HAPLN2	60484	broad.mit.edu	37	chr1	156594397	156594397	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgccgtctcccgccagcttgGaccgagggtctggactggtg	15	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:156594397G>A	uc001fpn.1	+	6	968	c.561G>A	c.(559-561)TGG>TGA	p.W187*		NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	187	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGCCAGCTTGGACCGAGGGTC	0.716													0	0	0	0.006214	0	6	77										A	156594397	G	A	156594397	4	1	54	1	0	0	0	0	0	1	0	0	6955	1183	41	1	575	1	HAPLN2	1	156594397	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	29174	156594397	92656224	99	14877										
NES	10763	broad.mit.edu	37	chr1	156642912	156642912	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtagcaggcaagggtgagggGagggaagttgggctcaggac	21	5	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:156642912G>T	uc001fpq.2	-	4	1201	c.1068C>A	c.(1066-1068)CTC>CTA	p.L356L		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	356	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGGTGAGGGGAGGGAAGTTG	0.602													1	0	6.40141e-05	0.010729	6.60002e-05	11	67										T	156642912	G	T	156642912	2	4	54	1	0	0	0	0	0	0	0	1	10337	1161	41	3		3	NES	1	156642912	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	48515	156642912	92607709	100	14878										
INSRR	3645	broad.mit.edu	37	chr1	156815422	156815422	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttcgcacatggggatggtGatcgcgttgtgtagaaagtt	14	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:156815422G>A	uc010pht.1	-	10	2417	c.2163C>T	c.(2161-2163)ATC>ATT	p.I721I	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	721					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGATGGTGATCGCGTTGT	0.642													0	0	0	0.006214	0	9	85										A	156815422	G	A	156815422	2	1	54	1	0	0	0	0	0	0	0	1	7774	1280	45	1		1	INSRR	1	156815422	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	172510	156815422	92435199	101	14879										
NTRK1	4914	broad.mit.edu	37	chr1	156830838	156830838	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgggcgccgcaccctgccccGatgcctgctgcccccacggc	12	22	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:156830838G>A	uc001fqh.1	+	1	168	c.112G>A	c.(112-114)GAT>AAT	p.D38N	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc010pht.1_5'Flank|INSRR_uc009wsj.1_5'Flank|NTRK1_uc001fqi.1_Missense_Mutation_p.D38N|NTRK1_uc009wsk.1_Missense_Mutation_p.D38N	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	38	Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	ACCCTGCCCCGATGCCTGCTG	0.726			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			0	0	0	0.004482	0	7	22										A	156830838	G	A	156830838	3	1	54	1	0	0	0	0	1	0	0	0	10706	1058	37	1	244	1	NTRK1	1	156830838	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	15416	156830838	92419783	102	14880										
SPTA1	6708	broad.mit.edu	37	chr1	158632519	158632519	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtggaagtagctgagggttCagtctcttggatccaggcct	15	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:158632519C>T	uc001fst.1	-	17	2636	c.2437G>A	c.(2437-2439)GAA>AAA	p.E813K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	813	Spectrin 9.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GCTGAGGGTTCAGTCTCTTGG	0.512													0	0	0	0.006214	0	7	51										T	158632519	C	T	158632519	3	4	54	1	0	0	0	0	1	0	0	0	15115	835	29	1	4966	1	SPTA1	1	158632519	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1801681	158632519	90618102	103	14881										
VANGL2	57216	broad.mit.edu	37	chr1	160389332	160389332	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctgcgccagctccagcctCagttcacgctcaaggtcgtg	11	15	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:160389332C>T	uc001fwb.1	+	5	1032	c.733C>T	c.(733-735)CAG>TAG	p.Q245*	VANGL2_uc001fwc.1_Nonsense_Mutation_p.Q245*	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	245	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCTCCAGCCTCAGTTCACGCT	0.647													0	0	0	0.009096	0	4	64										T	160389332	C	T	160389332	4	4	54	1	0	0	0	0	0	1	0	0	17117	827	29	1	743	1	VANGL2	1	160389332	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1756813	160389332	88861289	104	14882										
LY9	4063	broad.mit.edu	37	chr1	160793302	160793302	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgtgctctcccaaggatatGagaagctggacactcccctc	9	14	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:160793302G>C	uc001fwu.2	+	8	1596	c.1546G>C	c.(1546-1548)GAG>CAG	p.E516Q	LY9_uc001fwv.2_Missense_Mutation_p.E502Q|LY9_uc001fww.2_Missense_Mutation_p.E426Q|LY9_uc001fwx.2_Missense_Mutation_p.E426Q|LY9_uc001fwy.1_Missense_Mutation_p.E314Q|LY9_uc001fwz.2_Missense_Mutation_p.E154Q	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	516	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCAAGGATATGAGAAGCTGGA	0.552													0	0	0	0.004672	0	3	71										C	160793302	G	C	160793302	3	2	54	1	0	0	0	0	1	0	0	0	9101	1291	45	1	1708	1	LY9	1	160793302	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	403970	160793302	88457319	105	14883										
MPZ	4359	broad.mit.edu	37	chr1	161276525	161276525	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaagacatacagcgtgacctGagaggtcttgcccactatgt	10	10	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:161276525G>A	uc001gaf.3	-	3	488	c.451C>T	c.(451-453)CAG>TAG	p.Q151*	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	141	Ig-like V-type.|Extracellular (Potential).				synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGCGTGACCTGAGAGGTCTTG	0.507													0	0	0	0.003163	0	12	100										A	161276525	G	A	161276525	4	1	54	1	0	0	0	0	0	1	0	0	9748	1299	45	1	341	1	MPZ	1	161276525	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	483223	161276525	87974096	106	14884										
FCGR3B	2215	broad.mit.edu	37	chr1	161596168	161596168	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttcctccttgaacacccacCgaggggcctggagcaacagc	10	16	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:161596168C>T	uc009wul.2	-	4	618	c.344G>A	c.(343-345)CGG>CAG	p.R115Q		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	115					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GAACACCCACCGAGGGGCCTG	0.562													0	0	0	0.001168	0	5	40										T	161596168	C	T	161596168	3	4	54	1	0	0	0	0	1	0	0	0	5785	652	23	2	365	2	FCGR3B	1	161596168	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	319643	161596168	87654453	107	14885										
FCRLA	84824	broad.mit.edu	37	chr1	161681858	161681858	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctcttctccttctacaagGatggaaggatagtgcaaagc	9	10	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:161681858G>A	uc001gbe.2	+	5	945	c.703G>A	c.(703-705)GAT>AAT	p.D235N	FCRLA_uc001gbd.2_Missense_Mutation_p.D229N|FCRLA_uc001gbf.2_Missense_Mutation_p.D140N|FCRLA_uc001gbg.2_Missense_Mutation_p.D89N|FCRLA_uc009wuo.2_Missense_Mutation_p.D95N|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	212	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			CTTCTACAAGGATGGAAGGAT	0.562													0	0	0	0.004482	0	9	77										A	161681858	G	A	161681858	3	1	54	1	0	0	0	0	1	0	0	0	5800	1174	41	1	721	1	FCRLA	1	161681858	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	85690	161681858	87568763	108	14886										
OLFML2B	25903	broad.mit.edu	37	chr1	161993194	161993194	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accacaatcagagcgaagtaGagaactagcagccgaggctt	11	10	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:161993194G>A	uc001gbu.2	-	1	451	c.27C>T	c.(25-27)CTC>CTT	p.L9L	OLFML2B_uc010pkq.1_Silent_p.L9L	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	9										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GAGCGAAGTAGAGAACTAGCA	0.632													0	0	0	0.001168	0	6	56										A	161993194	G	A	161993194	2	1	54	1	0	0	0	0	0	0	0	1	10858	929	33	1		1	OLFML2B	1	161993194	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	311336	161993194	87257427	109	14887										
UAP1	6675	broad.mit.edu	37	chr1	162535885	162535885	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attaatgacctcaaactcacGttgtccaaagctgggcaaga	8	10	2	2	rs151151506		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:162535885G>A	uc001gce.3	+	2	356	c.27G>A	c.(25-27)ACG>ACA	p.T9T		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	9					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TCAAACTCACGTTGTCCAAAG	0.413													0	0	0	0.00245	0	10	90										A	162535885	G	A	162535885	2	1	54	1	0	0	0	0	0	0	0	1	16822	1132	40	2		2	UAP1	1	162535885	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	542691	162535885	86714736	110	14888										
POU2F1	5451	broad.mit.edu	37	chr1	167367230	167367230	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtattttcttcattcttacaGagaacctctcatctgattcg	5	10	5	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:167367230G>A	uc001gec.2	+	12	1223	c.1061_splice	c.e12-1	p.E354_splice	POU2F1_uc001ged.2_Splice_Site_p.E352_splice|POU2F1_uc001gee.2_Splice_Site_p.E354_splice|POU2F1_uc010plh.1_Splice_Site_p.E291_splice|POU2F1_uc001gef.2_Splice_Site_p.E366_splice|POU2F1_uc001geg.2_Splice_Site_p.E252_splice|POU2F1_uc009wvg.1_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1						negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						CATTCTTACAGAGAACCTCTC	0.413													0	0	0	0.00308	0	6	26										A	167367230	G	A	167367230	5	1	54	1	0	0	0	0	0	0	1	0	12271	956	33	1	1098	1	POU2F1	1	167367230	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4831345	167367230	81883391	111	14889										
RCSD1	92241	broad.mit.edu	37	chr1	167653186	167653186	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggacaactcggcgtccccctCggtggcccagctggccgggc	15	17	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:167653186C>A	uc001gem.2	+	2	243	c.56C>A	c.(55-57)TCG>TAG	p.S19*	RCSD1_uc010pli.1_Nonsense_Mutation_p.S19*	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	19										ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					GCGTCCCCCTCGGTGGCCCAG	0.602													1	0	1.19403e-26	0.00361	1.29171e-26	47	376										A	167653186	C	A	167653186	4	1	54	1	0	0	0	0	0	1	0	0	13185	893	31	3	62	3	RCSD1	1	167653186	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	285956	167653186	81597435	112	14890										
ADCY10	55811	broad.mit.edu	37	chr1	167778974	167778974	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgtttttttgaagatcctGaatgtttaccctgcctgcta	7	8	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:167778974G>C	uc001ger.2	-	33	5072	c.4774C>G	c.(4774-4776)CAG>GAG	p.Q1592E	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.Q1500E|ADCY10_uc010plj.1_Missense_Mutation_p.Q1439E	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1592					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TGAAGATCCTGAATGTTTACC	0.373													0	0	0	0.009096	0	3	87										C	167778974	G	C	167778974	3	2	54	1	0	0	0	0	1	0	0	0	293	1299	45	1	62	1	ADCY10	1	167778974	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	125788	167778974	81471647	113	14891										
ADCY10	55811	broad.mit.edu	37	chr1	167849781	167849781	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tatatccatagcacattccaGagcatgagtgagctcgtcag	9	10	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:167849781G>A	uc001ger.2	-	10	1385	c.1087C>T	c.(1087-1089)CTG>TTG	p.L363L	ADCY10_uc009wvk.2_Silent_p.L271L|ADCY10_uc010plj.1_Silent_p.L210L|ADCY10_uc009wvl.2_Silent_p.L362L|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	363	Guanylate cyclase 2.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						GCACATTCCAGAGCATGAGTG	0.522													0	0	0	0.010729	0	12	93										A	167849781	G	A	167849781	2	1	54	1	0	0	0	0	0	0	0	1	293	933	33	1		1	ADCY10	1	167849781	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	70807	167849781	81400840	114	14892										
SLC19A2	10560	broad.mit.edu	37	chr1	169437922	169437922	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgtagatgattctgaagaCaacataggatgcatagcaca	9	7	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:169437922C>G	uc001gge.3	-	4	1387	c.1183G>C	c.(1183-1185)GTC>CTC	p.V395L	SLC19A2_uc001ggf.3_Missense_Mutation_p.V194L	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	395	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					ATTCTGAAGACAACATAGGAT	0.383													0	0	0	0.00308	0	5	56										G	169437922	C	G	169437922	3	3	54	1	0	0	0	0	1	0	0	0	14429	478	17	4	322	4	SLC19A2	1	169437922	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1588141	169437922	79812699	115	14893										
SLC19A2	10560	broad.mit.edu	37	chr1	169446801	169446801	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaatttcagtggctgtggcGatgccataaaaaaattctag	10	7	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:169446801G>A	uc001gge.3	-	2	603	c.399C>T	c.(397-399)ATC>ATT	p.I133I	SLC19A2_uc001ggf.3_Intron	NM_006996	NP_008927	O60779	S19A2_HUMAN	solute carrier family 19, member 2	133	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity				0	all_hematologic(923;0.208)					TGGCTGTGGCGATGCCATAAA	0.453													0	0	0	0.010729	0	10	94										A	169446801	G	A	169446801	2	1	54	1	0	0	0	0	0	0	0	1	14429	1048	37	1		1	SLC19A2	1	169446801	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8879	169446801	79803820	116	14894										
F5	2153	broad.mit.edu	37	chr1	169512269	169512269	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atatgagtcttcatcatcatCtgggatacatttaacatccc	5	10	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:169512269C>T	uc001ggg.1	-	13	2204	c.2059G>A	c.(2059-2061)GAT>AAT	p.D687N		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	687					cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCATCATCATCTGGGATACAT	0.398													0	0	0	0.001168	0	6	53										T	169512269	C	T	169512269	3	4	54	1	0	0	0	0	1	0	0	0	5348	913	32	1	4667	1	F5	1	169512269	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	65468	169512269	79738352	117	14895										
PRDX6	9588	broad.mit.edu	37	chr1	173454533	173454533	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaattgtgaagagcccacaGaaaagttaccttttcccatc	6	11	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:173454533G>A	uc001giy.1	+	3	337	c.286G>A	c.(286-288)GAA>AAA	p.E96K		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	96	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						AGAGCCCACAGAAAAGTTACC	0.438													0	0	0	0.009096	0	3	37										A	173454533	G	A	173454533	3	1	54	1	0	0	0	0	1	0	0	0	12469	943	33	1	296	1	PRDX6	1	173454533	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3942264	173454533	75796088	118	14896										
GPR52	9293	broad.mit.edu	37	chr1	174417291	174417291	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaatggaggatcctgaacatGagcagtggcattgtgaatgt	14	5	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:174417291G>T	uc001gka.1	+	1	80	c.42G>T	c.(40-42)ATG>ATT	p.M14I	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	14	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						TCCTGAACATGAGCAGTGGCA	0.507													1	0	2.61681e-11	0.00245	2.77755e-11	12	91										T	174417291	G	T	174417291	3	4	54	1	0	0	0	0	1	0	0	0	6698	1290	45	3	44	3	GPR52	1	174417291	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	962758	174417291	74833330	119	14897										
TNN	63923	broad.mit.edu	37	chr1	175097777	175097777	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gactgcagtcaggttcagcaGaacagcaatgccgccagtgg	13	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:175097777G>A	uc001gkl.1	+	15	3338	c.3225G>A	c.(3223-3225)CAG>CAA	p.Q1075Q		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1075	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGGTTCAGCAGAACAGCAATG	0.582													0	0	0	0.00361	0	80	197										A	175097777	G	A	175097777	2	1	54	1	0	0	0	0	0	0	0	1	16320	933	33	1		1	TNN	1	175097777	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	680486	175097777	74152844	120	14898										
TNR	7143	broad.mit.edu	37	chr1	175372540	175372540	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagcccccgggagctgcagtCtgttgggcaccggagttcgg	17	12	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:175372540C>T	uc001gkp.1	-	2	793	c.712G>A	c.(712-714)GAC>AAC	p.D238N	TNR_uc009wwu.1_Missense_Mutation_p.D238N|TNR_uc010pmz.1_Missense_Mutation_p.D238N	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	238	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GAGCTGCAGTCTGTTGGGCAC	0.647													0	0	0	0.009535	0	30	310										T	175372540	C	T	175372540	3	4	54	1	0	0	0	0	1	0	0	0	16335	913	32	1	3444	1	TNR	1	175372540	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	274763	175372540	73878081	121	14899										
ASTN1	460	broad.mit.edu	37	chr1	176833599	176833599	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcttatcttgggttcctgaaGgagtccattgcaccaactgc	10	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:176833599G>A	uc001glc.2	-	23	3918	c.3706C>T	c.(3706-3708)CTT>TTT	p.L1236F	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1244					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GGTTCCTGAAGGAGTCCATTG	0.532													0	0	0	0.00308	0	7	60										A	176833599	G	A	176833599	3	1	54	1	0	0	0	0	1	0	0	0	1064	1000	35	2	182	2	ASTN1	1	176833599	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1461059	176833599	72417022	122	14900										
SEC16B	89866	broad.mit.edu	37	chr1	177937001	177937001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctctctccattgtgccaaGagtgagggacaggccgatga	12	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:177937001G>C	uc001gli.1	-	2	206	c.116C>G	c.(115-117)TCT>TGT	p.S39C	SEC16B_uc001glk.1_5'UTR|SEC16B_uc009wwz.1_5'UTR|SEC16B_uc001glj.1_Missense_Mutation_p.S39C|SEC16B_uc001gll.3_Missense_Mutation_p.S39C	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	39	Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						ATTGTGCCAAGAGTGAGGGAC	0.607													0	0	0	0.002299	0	20	150										C	177937001	G	C	177937001	3	2	54	1	0	0	0	0	1	0	0	0	13987	942	33	1	3166	1	SEC16B	1	177937001	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1103402	177937001	71313620	123	14901										
TOR3A	64222	broad.mit.edu	37	chr1	179054980	179054980	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgactgtgtcaggatgttCatcgccacgttccactttcc	9	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:179054980C>T	uc001gmd.2	+	3	743	c.591C>T	c.(589-591)TTC>TTT	p.F197F	TOR3A_uc010pnd.1_Intron	NM_022371	NP_071766	Q9H497	TOR3A_HUMAN	torsin family 3, member A precursor	197					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum	ATP binding			pancreas(1)	1						TCAGGATGTTCATCGCCACGT	0.592													0	0	0	0.007413	0	19	139										T	179054980	C	T	179054980	2	4	54	1	0	0	0	0	0	0	0	1	16373	825	29	1		1	TOR3A	1	179054980	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1117979	179054980	70195641	124	14902										
TDRD5	163589	broad.mit.edu	37	chr1	179600039	179600039	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctagtgtttgatgcggataaGaagcctctaccacctggtga	11	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:179600039G>A	uc001gnf.1	+	7	1360	c.1110G>A	c.(1108-1110)AAG>AAA	p.K370K	TDRD5_uc010pnp.1_Silent_p.K370K|TDRD5_uc001gnh.1_5'UTR	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	370	Lotus/OST-HTH 3.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						ATGCGGATAAGAAGCCTCTAC	0.413													0	0	0	0.008291	0	4	84										A	179600039	G	A	179600039	2	1	54	1	0	0	0	0	0	0	0	1	15730	933	33	1		1	TDRD5	1	179600039	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	545059	179600039	69650582	125	14903										
TOR1AIP1	26092	broad.mit.edu	37	chr1	179883175	179883175	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcttggaaaccagtcaccatCaacctccagccgacgtaagt	8	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:179883175C>G	uc001gnq.2	+	9	1168	c.950C>G	c.(949-951)TCA>TGA	p.S317*		NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	317	Nuclear (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						CAGTCACCATCAACCTCCAGC	0.303													0	0	0	0.001984	0	4	52										G	179883175	C	G	179883175	4	3	54	1	0	0	0	0	0	1	0	0	16369	838	29	1	984	1	TOR1AIP1	1	179883175	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	283136	179883175	69367446	126	14904										
HMCN1	83872	broad.mit.edu	37	chr1	186037086	186037086	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctccagctaccatcacctGgtttaaggatggcactcctt	7	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:186037086G>A	uc001grq.1	+	50	8055	c.7826G>A	c.(7825-7827)TGG>TAG	p.W2609*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2609	Ig-like C2-type 24.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACCATCACCTGGTTTAAGGAT	0.428													0	0	0	0.002299	0	16	62										A	186037086	G	A	186037086	4	1	54	1	0	0	0	0	0	1	0	0	7220	1357	47	2	8024	2	HMCN1	1	186037086	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6153911	186037086	63213535	127	14905										
TPR	7175	broad.mit.edu	37	chr1	186322838	186322838	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acttctgcgacagctagcttCtcatttgctcctctcaaatc	5	14	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:186322838C>T	uc001grv.2	-	18	2613	c.2316G>A	c.(2314-2316)GAG>GAA	p.E772E		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	772	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CAGCTAGCTTCTCATTTGCTC	0.363			T	NTRK1	papillary thyroid								0	0	0	0.00278	0	17	135										T	186322838	C	T	186322838	2	4	54	1	0	0	0	0	0	0	0	1	16413	912	32	1		1	TPR	1	186322838	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	285752	186322838	62927783	128	14906										
FAM5C	339479	broad.mit.edu	37	chr1	190250836	190250836	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggagagccaaggaaatttCttctctcaactgcaaggtta	10	8	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:190250836C>T	uc001gse.1	-	3	513	c.281G>A	c.(280-282)AGA>AAA	p.R94K	FAM5C_uc010pot.1_Intron	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	94						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AAGGAAATTTCTTCTCTCAAC	0.398													0	0	0	0.004672	0	3	9										T	190250836	C	T	190250836	3	4	54	1	0	0	0	0	1	0	0	0	5594	913	32	1	2043	1	FAM5C	1	190250836	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3927998	190250836	58999785	129	14907										
PHLDA3	23612	broad.mit.edu	37	chr1	201437671	201437671	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggggcagcggaagtcgatctCgccgcccccttcggtcacca	13	16	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:201437671C>T	uc001gwq.2	-	1	629	c.244G>A	c.(244-246)GAG>AAG	p.E82K	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	82	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						AAGTCGATCTCGCCGCCCCCT	0.652													0	0	0	0.00361	0	62	139										T	201437671	C	T	201437671	3	4	54	1	0	0	0	0	1	0	0	0	11850	893	31	1	143	1	PHLDA3	1	201437671	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11186835	201437671	47812950	130	14908										
RNPEP	6051	broad.mit.edu	37	chr1	201965372	201965372	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caacaggagagaagctttttGgaccttatgtttggggaagg	14	5	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:201965372G>A	uc001gxd.2	+	4	864	c.835G>A	c.(835-837)GGA>AGA	p.G279R	RNPEP_uc001gxe.2_5'UTR|RNPEP_uc001gxf.2_Missense_Mutation_p.G148R	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	279					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		GAAGCTTTTTGGACCTTATGT	0.493													0	0	0	0.008871	0	13	147										A	201965372	G	A	201965372	3	1	54	1	0	0	0	0	1	0	0	0	13509	1349	47	2	849	2	RNPEP	1	201965372	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	527701	201965372	47285249	131	14909										
PPP1R15B	84919	broad.mit.edu	37	chr1	204380470	204380470	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgcgatcgccgagggaaaaAgggtggccagaaccggaagc	16	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:204380470A>G	uc001hav.3	-	1	475	c.70T>C	c.(70-72)TTT>CTT	p.F24L		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	24					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CGAGGGAAAAAGGGTGGCCAG	0.627													0	0	0	0.001168	0	4	117										G	204380470	A	G	204380470	3	3	54	1	0	0	0	0	1	0	0	0	12364	72	3	5	2079	5	PPP1R15B	1	204380470	Missense_Mutation	SNP	A	TCGA-DK-A2I4-01A-11D-A21A-08	2415098	204380470	44870151	132	14910										
SLC45A3	85414	broad.mit.edu	37	chr1	205628553	205628553	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actatccaggatggcgaggtCcaggcagatgccccggcccg	14	14	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:205628553C>A	uc001hda.1	-	5	1810	c.1471G>T	c.(1471-1473)GAC>TAC	p.D491Y	SLC45A3_uc010prn.1_Intron|SLC45A3_uc010pro.1_Intron|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	491					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			ATGGCGAGGTCCAGGCAGATG	0.642			T	ETV1|ETV5|ELK4|ERG	prostate 						OREG0014161	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.32416e-17	0.002299	2.50175e-17	18	46										A	205628553	C	A	205628553	3	1	54	1	0	0	0	0	1	0	0	0	14642	855	30	3	194	3	SLC45A3	1	205628553	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1248083	205628553	43622068	133	14911										
AVPR1B	553	broad.mit.edu	37	chr1	206224493	206224493	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacccctcggggcaccctctCtgcccccaatgccacaacac	6	22	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:206224493C>G	uc001hds.2	+	1	211	c.53C>G	c.(52-54)TCT>TGT	p.S18C		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	18	Extracellular (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	GGCACCCTCTCTGCCCCCAAT	0.652													0	0	0	0.00361	0	109	506										G	206224493	C	G	206224493	3	3	54	1	0	0	0	0	1	0	0	0	1232	913	32	1	55	1	AVPR1B	1	206224493	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	595940	206224493	43026128	134	14912										
DYRK3	8444	broad.mit.edu	37	chr1	206821558	206821558	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcactgcgatctgaagccaGaaaacattctcctgaaacac	6	12	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:206821558G>C	uc001hej.2	+	3	1183	c.1015G>C	c.(1015-1017)GAA>CAA	p.E339Q	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Missense_Mutation_p.E319Q	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	339	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TCTGAAGCCAGAAAACATTCT	0.468													0	0	0	0.00499	0	14	80										C	206821558	G	C	206821558	3	2	54	1	0	0	0	0	1	0	0	0	4857	943	33	1	1046	1	DYRK3	1	206821558	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	597065	206821558	42429063	135	14913			2	59	190834117	3	3	348	G		7.613586e-05
DYRK3	8444	broad.mit.edu	37	chr1	206821678	206821678	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcggttctacagagctccaGaaatcatcttaggaagccgc	9	12	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:206821678G>C	uc001hej.2	+	3	1303	c.1135G>C	c.(1135-1137)GAA>CAA	p.E379Q	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Missense_Mutation_p.E359Q	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	379	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CAGAGCTCCAGAAATCATCTT	0.488													0	0	0	0.00245	0	12	65										C	206821678	G	C	206821678	3	2	54	1	0	0	0	0	1	0	0	0	4857	943	33	1	1166	1	DYRK3	1	206821678	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	120	206821678	42428943	136	14914			2	59	190834117	3	3	348	G		7.613586e-05
DYRK3	8444	broad.mit.edu	37	chr1	206821905	206821905	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ataccccgctactgctctgtGactacccaggcagatgggag	11	13	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:206821905G>A	uc001hej.2	+	3	1530	c.1362G>A	c.(1360-1362)GTG>GTA	p.V454V	DYRK3_uc001hek.2_Intron|DYRK3_uc001hei.2_Silent_p.V434V	NM_003582	NP_003573	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	454	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|central_nervous_system(1)	3	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			ACTGCTCTGTGACTACCCAGG	0.552													0	0	0	0.011902	0	35	372										A	206821905	G	A	206821905	2	1	54	1	0	0	0	0	0	0	0	1	4857	1277	45	1		1	DYRK3	1	206821905	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	227	206821905	42428716	137	14915			2	59	190834117	3	3	348	G		7.613586e-05
CR1	1378	broad.mit.edu	37	chr1	207679266	207679266	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggtcaatgcaatgccccaGaatggcttccatttgccagg	10	12	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:207679266G>A	uc001hfy.2	+	2	279	c.139G>A	c.(139-141)GAA>AAA	p.E47K	CR1_uc009xcl.1_Missense_Mutation_p.E47K|CR1_uc001hfx.2_Missense_Mutation_p.E47K|CR1_uc010psg.1_Missense_Mutation_p.E47K|CR1_uc009xcj.1_Missense_Mutation_p.E47K|CR1_uc009xck.1_Missense_Mutation_p.E47K	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	47	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CAATGCCCCAGAATGGCTTCC	0.373													0	0	0	0.006122	0	15	58										A	207679266	G	A	207679266	3	1	54	1	0	0	0	0	1	0	0	0	3840	943	33	1	145	1	CR1	1	207679266	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	857361	207679266	41571355	138	14916										
IRF6	3664	broad.mit.edu	37	chr1	209968639	209968639	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catcatccccactcaccattGatgttcaggaaggggaaggt	10	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:209968639G>A	uc001hhq.1	-	5	767	c.504C>T	c.(502-504)ATC>ATT	p.I168I	IRF6_uc010psm.1_Silent_p.I73I|IRF6_uc009xct.1_Silent_p.I168I	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	168					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		ACTCACCATTGATGTTCAGGA	0.488										HNSCC(57;0.16)			0	0	0	0.00361	0	40	141										A	209968639	G	A	209968639	2	1	54	1	0	0	0	0	0	0	0	1	7834	1280	45	1		1	IRF6	1	209968639	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2289373	209968639	39281982	139	14917										
USH2A	7399	broad.mit.edu	37	chr1	215916588	215916588	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attttccagaagggtggattGatgatgaccaacggagaagg	14	5	0	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:215916588G>A	uc001hku.1	-	59	11866	c.11479C>T	c.(11479-11481)CAA>TAA	p.Q3827*		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3827	Fibronectin type-III 23.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGGTGGATTGATGATGACCA	0.438										HNSCC(13;0.011)			0	0	0	0.011902	0	34	113										A	215916588	G	A	215916588	4	1	54	1	0	0	0	0	0	1	0	0	17033	1299	45	1	4185	1	USH2A	1	215916588	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5947949	215916588	33334033	140	14918										
PARP1	142	broad.mit.edu	37	chr1	226555291	226555291	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcgatgtccagcaggttgtCaagcatttccaccttggcct	9	13	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:226555291C>T	uc001hqd.3	-	17	2467	c.2296G>A	c.(2296-2298)GAC>AAC	p.D766N		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	766	PARP alpha-helical.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		AGCAGGTTGTCAAGCATTTCC	0.512								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.002836	0	25	73										T	226555291	C	T	226555291	3	4	54	1	0	0	0	0	1	0	0	0	11454	826	29	1	776	1	PARP1	1	226555291	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10638703	226555291	22695330	141	14919										
PARP1	142	broad.mit.edu	37	chr1	226567866	226567866	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attcatcttttccacctcctCtgttcaaattgaaaggaaaa	4	10	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:226567866C>G	uc001hqd.3	-	10	1472	c.1301_splice	c.e10-1	p.K434_splice		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1						cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TCCACCTCCTCTGTTCAAATT	0.388								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.009096	0	3	26										G	226567866	C	G	226567866	5	3	54	1	0	0	0	0	0	0	1	0	11454	927	32	1	1800	1	PARP1	1	226567866	Splice_Site	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	12575	226567866	22682755	142	14920										
WNT3A	89780	broad.mit.edu	37	chr1	228210479	228210479	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttctgcaggaactacgtggaGatcatgcccagcgtggccga	13	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:228210479G>T	uc001hrq.1	+	2	261	c.183G>T	c.(181-183)GAG>GAT	p.E61D	WNT3A_uc001hrp.1_Missense_Mutation_p.E61D	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	61					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				ACTACGTGGAGATCATGCCCA	0.652													1	0	9.65021e-13	0.010818	1.02851e-12	26	111										T	228210479	G	T	228210479	3	4	54	1	0	0	0	0	1	0	0	0	17386	933	33	3	189	3	WNT3A	1	228210479	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1642613	228210479	21040142	143	14921										
OBSCN	84033	broad.mit.edu	37	chr1	228466439	228466439	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgggacaagattgccatggaGaagcaccgcggtgtgctgga	16	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:228466439G>A	uc009xez.1	+	26	6953	c.6909G>A	c.(6907-6909)GAG>GAA	p.E2303E	OBSCN_uc001hsn.2_Silent_p.E2303E|OBSCN_uc001hsp.1_Silent_p.E2E|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2303	Ig-like 23.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TTGCCATGGAGAAGCACCGCG	0.667													0	0	0	0.00361	0	40	139										A	228466439	G	A	228466439	2	1	54	1	0	0	0	0	0	0	0	1	10812	933	33	1		1	OBSCN	1	228466439	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	255960	228466439	20784182	144	14922										
SIPA1L2	57568	broad.mit.edu	37	chr1	232615474	232615474	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agagtgcgtgcccgtggaatCagctgaaaacaaagatgaat	12	7	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:232615474C>T	uc001hvg.2	-	5	2142	c.1984G>A	c.(1984-1986)GAT>AAT	p.D662N		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	662	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCGTGGAATCAGCTGAAAAC	0.398													0	0	0	0.001368	0	11	39										T	232615474	C	T	232615474	3	4	54	1	0	0	0	0	1	0	0	0	14330	826	29	1	3252	1	SIPA1L2	1	232615474	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4149035	232615474	16635147	145	14923										
TOMM20	9804	broad.mit.edu	37	chr1	235292007	235292007	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccccgcatacaccggcggcGatggcgctgttccgacccac	12	18	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:235292007G>A	uc001hwl.2	-	1	250	c.24C>T	c.(22-24)ATC>ATT	p.I8I	SNORA14B_uc001hwm.1_5'Flank	NM_014765	NP_055580	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20	8	Helical; (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding				0	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)			CACCGGCGGCGATGGCGCTGT	0.607													0	0	0	0.00361	0	72	168										A	235292007	G	A	235292007	2	1	54	1	0	0	0	0	0	0	0	1	16351	1048	37	1		1	TOMM20	1	235292007	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2676533	235292007	13958614	146	14924										
ARID4B	51742	broad.mit.edu	37	chr1	235345386	235345386	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggtggggaagctgcagcctCagtatcagagtctgaaaaaa	13	8	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:235345386C>T	uc001hwq.2	-	20	3346	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	ARID4B_uc001hwr.2_Missense_Mutation_p.E864K|ARID4B_uc001hws.3_Missense_Mutation_p.E864K|ARID4B_uc001hwp.2_RNA|ARID4B_uc001hwt.3_Missense_Mutation_p.E631K	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	950					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GCTGCAGCCTCAGTATCAGAG	0.517													0	0	0	0.004007	0	14	59										T	235345386	C	T	235345386	3	4	54	1	0	0	0	0	1	0	0	0	920	835	29	1	1110	1	ARID4B	1	235345386	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	53379	235345386	13905235	147	14925										
LYST	1130	broad.mit.edu	37	chr1	235920623	235920623	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctggtgatgggtggttaacGaggaccaaaagtgtatctgc	15	6	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:235920623G>A	uc001hxj.2	-	24	7192	c.7017C>T	c.(7015-7017)CTC>CTT	p.L2339L		NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2339					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGTGGTTAACGAGGACCAAAA	0.333									Chediak-Higashi_syndrome				0	0	0	0.010729	0	9	62										A	235920623	G	A	235920623	2	1	54	1	0	0	0	0	0	0	0	1	9128	1045	37	1		1	LYST	1	235920623	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	575237	235920623	13329998	148	14926										
NID1	4811	broad.mit.edu	37	chr1	236212147	236212147	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggagggggataagtcttctCgataataaaccttccccagg	11	9	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:236212147C>T	uc001hxo.2	-	2	470	c.368G>A	c.(367-369)CGA>CAA	p.R123Q	NID1_uc009xgd.2_Missense_Mutation_p.R123Q	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	123	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	TAAGTCTTCTCGATAATAAAC	0.567													0	0	0	0.004656	0	26	74										T	236212147	C	T	236212147	3	4	54	1	0	0	0	0	1	0	0	0	10414	884	31	1	3451	1	NID1	1	236212147	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	291524	236212147	13038474	149	14927										
CEP170	9859	broad.mit.edu	37	chr1	243328189	243328189	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacactagaggtttggtcatCatctgttaagtctactgagg	10	7	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:243328189C>T	uc001hzs.2	-	13	3481	c.3073G>A	c.(3073-3075)GAT>AAT	p.D1025N	CEP170_uc001hzt.2_Missense_Mutation_p.D927N|CEP170_uc001hzu.2_Missense_Mutation_p.D927N|CEP170_uc001hzv.1_Missense_Mutation_p.D403N	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1025	Targeting to microtubules.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GTTTGGTCATCATCTGTTAAG	0.423													0	0	0	0.006214	0	8	41										T	243328189	C	T	243328189	3	4	54	1	0	0	0	0	1	0	0	0	3250	826	29	1	1743	1	CEP170	1	243328189	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7116042	243328189	5922432	150	14928										
PPPDE1	51029	broad.mit.edu	37	chr1	244868944	244868944	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttctacagagttgcctcccGaaggagtggctcacgcccgc	11	14	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:244868944G>A	uc001iao.2	+	5	702	c.438G>A	c.(436-438)CCG>CCA	p.P146P	PPPDE1_uc001iap.2_Silent_p.P113P|PPPDE1_uc001iaq.1_RNA	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	146	PPPDE peptidase.									breast(3)	3						GTTGCCTCCCGAAGGAGTGGC	0.537													0	0	0	0.00361	0	38	129										A	244868944	G	A	244868944	2	1	54	1	0	0	0	0	0	0	0	1	12408	1045	37	1		1	PPPDE1	1	244868944	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1540755	244868944	4381677	151	14929										
NLRP3	114548	broad.mit.edu	37	chr1	247587980	247587980	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttcaccatgtgcttcatccCcctggtctgctggatcgtgt	9	14	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:247587980C>T	uc001icr.2	+	5	1373	c.1235C>T	c.(1234-1236)CCC>CTC	p.P412L	NLRP3_uc001ics.2_Missense_Mutation_p.P412L|NLRP3_uc001icu.2_Missense_Mutation_p.P412L|NLRP3_uc001icw.2_Missense_Mutation_p.P412L|NLRP3_uc001icv.2_Missense_Mutation_p.P412L|NLRP3_uc010pyw.1_Missense_Mutation_p.P410L|NLRP3_uc001ict.1_Missense_Mutation_p.P410L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	412	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGCTTCATCCCCCTGGTCTGC	0.542													0	0	0	0.001168	0	5	91										T	247587980	C	T	247587980	3	4	54	1	0	0	0	0	1	0	0	0	10478	623	22	2	1245	2	NLRP3	1	247587980	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2719036	247587980	1662641	152	14930										
SH3BP5L	80851	broad.mit.edu	37	chr1	249106422	249106422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccacgggggaggagcgccGagggcccagggggtggggag	23	11	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr1:249106422G>A	uc001iew.1	-	7	1411	c.859C>T	c.(859-861)CGG>TGG	p.R287W	SH3BP5L_uc010pzp.1_Missense_Mutation_p.R180W|SH3BP5L_uc010pzq.1_Missense_Mutation_p.R255W|SH3BP5L_uc001iev.1_Missense_Mutation_p.R168W	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	287											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GAGGAGCGCCGAGGGCCCAGG	0.721													0	0	0	0.00308	0	5	39										A	249106422	G	A	249106422	3	1	54	1	0	0	0	0	1	0	0	0	14248	1057	37	1	326	1	SH3BP5L	1	249106422	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1518442	249106422	144199	153	14931										
TAF1B	9014	broad.mit.edu	37	chr2	10045054	10045054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaacatttttagatttgcctCgttttccagacataactgaa	6	8	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:10045054C>T	uc002qzz.2	+	9	974	c.874C>T	c.(874-876)CGT>TGT	p.R292C	TAF1B_uc010exc.2_Missense_Mutation_p.R292C|TAF1B_uc002qzy.3_Missense_Mutation_p.R292C|TAF1B_uc010yja.1_Missense_Mutation_p.R37C|TAF1B_uc010exd.2_Missense_Mutation_p.R37C	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	292					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGATTTGCCTCGTTTTCCAGA	0.378													0	0	0	0.001168	0	6	53										T	10045054	C	T	10045054	3	4	54	1	0	0	0	0	1	0	0	0	15517	884	31	1	908	1	TAF1B	2	10045054	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08		10045054	233154319	154	14932										
MYCN	4613	broad.mit.edu	37	chr2	16085691	16085691	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagaagcggcgttcctcctcCaacaccaaggctgtcaccac	9	16	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:16085691C>T	uc002rci.2	+	3	1167	c.867C>T	c.(865-867)TCC>TCT	p.S289S	MYCN_uc010yjr.1_Silent_p.S281S	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	289					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			GTTCCTCCTCCAACACCAAGG	0.458			A		neuroblastoma								0	0	0	0.001368	0	12	73										T	16085691	C	T	16085691	2	4	54	1	0	0	0	0	0	0	0	1	10021	581	21	2		2	MYCN	2	16085691	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6040637	16085691	227113682	155	14933										
NT5C1B	93034	broad.mit.edu	37	chr2	18745124	18745124	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctaacctctgtgccccttCaatgtggaacatgtggtcat	8	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:18745124C>T	uc002rcz.2	-	10	1875	c.1771G>A	c.(1771-1773)GAA>AAA	p.E591K	NT5C1B_uc002rcy.2_Missense_Mutation_p.E591K|NT5C1B_uc010exr.2_Intron|NT5C1B_uc010yju.1_Missense_Mutation_p.E531K|NT5C1B_uc002rda.2_Missense_Mutation_p.E531K|NT5C1B_uc010yjv.1_Missense_Mutation_p.E608K|NT5C1B_uc010yjw.1_Missense_Mutation_p.E574K|NT5C1B_uc010exs.2_Missense_Mutation_p.E593K	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	591					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TGTGCCCCTTCAATGTGGAAC	0.468													0	0	0	0.001984	0	7	44										T	18745124	C	T	18745124	3	4	54	1	0	0	0	0	1	0	0	0	10686	835	29	1	65	1	NT5C1B	2	18745124	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2659433	18745124	224454249	156	14934										
OTOF	9381	broad.mit.edu	37	chr2	26700125	26700125	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtgccgcttcacctgggccCgcagcatcctggcctgctgc	12	17	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:26700125C>T	uc002rhk.2	-	21	2565	c.2438G>A	c.(2437-2439)CGG>CAG	p.R813Q	OTOF_uc002rhh.2_Missense_Mutation_p.R66Q|OTOF_uc002rhi.2_Missense_Mutation_p.R123Q|OTOF_uc002rhj.2_Missense_Mutation_p.R66Q	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	813	Cytoplasmic (Potential).|Potential.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTGGGCCCGCAGCATCCT	0.652													0	0	0	0.000602	0	5	29										T	26700125	C	T	26700125	3	4	54	1	0	0	0	0	1	0	0	0	11303	652	23	2	3844	2	OTOF	2	26700125	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7955001	26700125	216499248	157	14935										
EMILIN1	11117	broad.mit.edu	37	chr2	27308605	27308605	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgcggtgctgactgggcacCggcacgagaaagtggaggcc	18	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:27308605C>T	uc002rii.3	+	8	3201	c.2773C>T	c.(2773-2775)CGG>TGG	p.R925W	EMILIN1_uc002rik.3_Missense_Mutation_p.R160W|KHK_uc002ril.2_5'Flank|KHK_uc002rim.2_5'Flank|KHK_uc002rin.2_5'Flank|KHK_uc002rio.2_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	925	C1q.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACTGGGCACCGGCACGAGAA	0.667													0	0	0	0.003163	0	14	124										T	27308605	C	T	27308605	3	4	54	1	0	0	0	0	1	0	0	0	5093	643	23	2	2803	2	EMILIN1	2	27308605	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	608480	27308605	215890768	158	14936										
GTF3C2	2976	broad.mit.edu	37	chr2	27550106	27550106	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaatgcccctctccctcctGcatgcgcagcattggttctc	8	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:27550106G>T	uc002rjv.1	-	19	2818	c.2455C>A	c.(2455-2457)CAG>AAG	p.Q819K	MPV17_uc002rjt.2_5'Flank|GTF3C2_uc010eyy.1_Missense_Mutation_p.Q274K|GTF3C2_uc002rju.1_Missense_Mutation_p.Q830K|GTF3C2_uc002rjw.1_Missense_Mutation_p.Q819K	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	819						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCCCTCCTGCATGCGCAGC	0.507													1	0	0.00621372	0.006214	0.00633594	6	90										T	27550106	G	T	27550106	3	4	54	1	0	0	0	0	1	0	0	0	6873	1328	46	4	288	4	GTF3C2	2	27550106	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	241501	27550106	215649267	159	14937										
KRTCAP3	200634	broad.mit.edu	37	chr2	27666827	27666827	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttctgcagctagaggaaatGacagagcttgaatctcctaa	9	9	2	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:27666827G>A	uc002rks.2	+	6	644	c.627G>A	c.(625-627)ATG>ATA	p.M209I	KRTCAP3_uc010ylr.1_Missense_Mutation_p.M209I|KRTCAP3_uc002rkt.2_Missense_Mutation_p.M191I	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	209						integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					TAGAGGAAATGACAGAGCTTG	0.363													0	0	0	0.001984	0	5	45										A	27666827	G	A	27666827	3	1	54	1	0	0	0	0	1	0	0	0	8579	1290	45	1	649	1	KRTCAP3	2	27666827	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	116721	27666827	215532546	160	14938										
C2orf16	84226	broad.mit.edu	37	chr2	27804926	27804927	+	Frame_Shift_Ins	INS	-	-	TC													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcagtccctctgagaggagaINStctcacaggtcctttgagag							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:27804926_27804927insTC	uc002rkz.3	+	1	5538_5539	c.5487_5488insTC	c.(5485-5490)AGATCTfs	p.R1829fs	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1829_1830	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CTGAGAGGAGATCTCACAGGTC	0.55																		11	49	---	---								TC	27804927	-	TC	27804926	7	5	54	1	0	1	1	0	0	0	0	0	2157	330	12	0	5489	0	C2orf16	2	27804926	Frame_Shift_Ins	INS	-	TCGA-DK-A2I4-01A-11D-A21A-08	138099	27804926	215394447	161	14939										
XDH	7498	broad.mit.edu	37	chr2	31562480	31562480	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acgggtgtgcaggctcccctCgggggaatagtgtagctcct	15	11	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:31562480C>T	uc002rnv.1	-	34	3728	c.3649G>A	c.(3649-3651)GAG>AAG	p.E1217K		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1217					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	AGGCTCCCCTCGGGGGAATAG	0.612													0	0	0	0.001984	0	6	58										T	31562480	C	T	31562480	3	4	54	1	0	0	0	0	1	0	0	0	17423	893	31	1	364	1	XDH	2	31562480	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3757554	31562480	211636893	162	14940										
XDH	7498	broad.mit.edu	37	chr2	31598300	31598300	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actgtcaggtagaacttgaaGaagaagctgagggtgagggt	16	4	1	6			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:31598300G>A	uc002rnv.1	-	15	1627	c.1548C>T	c.(1546-1548)TTC>TTT	p.F516F		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	516				FFF -> LLL (in Ref. 3; AAA75287).	purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	AGAACTTGAAGAAGAAGCTGA	0.597													0	0	0	0.00245	0	12	108										A	31598300	G	A	31598300	2	1	54	1	0	0	0	0	0	0	0	1	17423	933	33	1		1	XDH	2	31598300	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	35820	31598300	211601073	163	14941										
BIRC6	57448	broad.mit.edu	37	chr2	32640519	32640519	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggactttggttcagtgcttGaggctgccaaagtttgcaga	14	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:32640519G>A	uc010ezu.2	+	10	2294	c.2160G>A	c.(2158-2160)TTG>TTA	p.L720L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	720					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTCAGTGCTTGAGGCTGCCAA	0.483													0	0	0	0.00308	0	7	20										A	32640519	G	A	32640519	2	1	54	1	0	0	0	0	0	0	0	1	1438	1281	45	1		1	BIRC6	2	32640519	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1042219	32640519	210558854	164	14942										
CRIM1	51232	broad.mit.edu	37	chr2	36669853	36669853	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcaagtcagactaactgcaGatggttgctgtactttgcca	9	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:36669853G>T	uc002rpd.2	+	4	883	c.844G>T	c.(844-846)GAT>TAT	p.D282Y		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	282	Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				ACTAACTGCAGATGGTTGCTG	0.468													1	0	6.12954e-19	0.004656	6.61439e-19	21	181										T	36669853	G	T	36669853	3	4	54	1	0	0	0	0	1	0	0	0	3873	942	33	3	858	3	CRIM1	2	36669853	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4029334	36669853	206529520	165	14943										
HEATR5B	54497	broad.mit.edu	37	chr2	37280645	37280645	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tatgtattaaaagtaaatacCtttagtgcactaagaacagc	6	6	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:37280645C>G	uc002rpp.1	-	17	2601	c.2505G>C	c.(2503-2505)AAG>AAC	p.K835N		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	835							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				AAGTAAATACCTTTAGTGCAC	0.308													0	0	0	0.00308	0	7	44										G	37280645	C	G	37280645	3	3	54	1	0	0	0	0	1	0	0	0	7032	695	24	4	3790	4	HEATR5B	2	37280645	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	610792	37280645	205918728	166	14944										
GALM	130589	broad.mit.edu	37	chr2	38893390	38893390	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagctgcagtcagacctcttGagagtggacatcatctcctg	10	12	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:38893390G>C	uc002rqy.2	+	1	339	c.87G>C	c.(85-87)TTG>TTC	p.L29F		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	29					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				CAGACCTCTTGAGAGTGGACA	0.602													0	0	0	0.008291	0	9	81										C	38893390	G	C	38893390	3	2	54	1	0	0	0	0	1	0	0	0	6205	1281	45	1	89	1	GALM	2	38893390	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1612745	38893390	204305983	167	14945										
ZFP36L2	678	broad.mit.edu	37	chr2	43452198	43452198	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgcaacttgggccgcggctCccgcgggaagcccaggtgca	16	14	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:43452198C>G	uc002rsv.3	-	2	1036	c.745G>C	c.(745-747)GAG>CAG	p.E249Q	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	249					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGCCGCGGCTCCCGCGGGAAG	0.617													0	0	0	0.009096	0	3	36										G	43452198	C	G	43452198	3	3	54	1	0	0	0	0	1	0	0	0	17644	864	30	1	743	1	ZFP36L2	2	43452198	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4558808	43452198	199747175	168	14946										
ABCG8	64241	broad.mit.edu	37	chr2	44102359	44102359	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctactggctggccaacctGaggccaggcctccagccctt	10	17	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:44102359G>A	uc002rtq.2	+	11	1653	c.1563G>A	c.(1561-1563)CTG>CTA	p.L521L	ABCG8_uc010yoa.1_Silent_p.L520L	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	521	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGGCCAACCTGAGGCCAGGCC	0.622													0	0	0	0.003163	0	12	140										A	44102359	G	A	44102359	2	1	54	1	0	0	0	0	0	0	0	1	72	1277	45	1		1	ABCG8	2	44102359	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	650161	44102359	199097014	169	14947										
SPTBN1	6711	broad.mit.edu	37	chr2	54843421	54843421	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcattgctgttgtggtgccaGatgaagacagctgggtgagt	16	6	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:54843421G>A	uc002rxu.2	+	5	801	c.552G>A	c.(550-552)CAG>CAA	p.Q184Q	SPTBN1_uc002rxv.1_Silent_p.Q184Q|SPTBN1_uc002rxx.2_Silent_p.Q171Q	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	184	CH 2.|Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			TGTGGTGCCAGATGAAGACAG	0.433													0	0	0	0.006122	0	15	75										A	54843421	G	A	54843421	2	1	54	1	0	0	0	0	0	0	0	1	15118	933	33	1		1	SPTBN1	2	54843421	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10741062	54843421	188355952	170	14948										
REL	5966	broad.mit.edu	37	chr2	61148963	61148963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggggtttcaagtcaagcaGaatcctactatccctcacct	7	13	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:61148963G>A	uc002sam.1	+	11	1377	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	REL_uc002san.1_Missense_Mutation_p.E353K	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	385					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			AAGTCAAGCAGAATCCTACTA	0.453			A		Hodgkin Lymphoma								0	0	0	0.006214	0	9	82										A	61148963	G	A	61148963	3	1	54	1	0	0	0	0	1	0	0	0	13215	943	33	1	1195	1	REL	2	61148963	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6305542	61148963	182050410	171	14949										
XPO1	7514	broad.mit.edu	37	chr2	61721193	61721193	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttaaagatttcagtttcttCtacttcagataccaacaaca	3	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:61721193C>T	uc002sbj.2	-	12	1809	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	XPO1_uc010fcl.2_Missense_Mutation_p.E357K|XPO1_uc010ypn.1_Missense_Mutation_p.E357K|XPO1_uc002sbk.2_5'UTR|XPO1_uc002sbh.2_Missense_Mutation_p.E8K	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	361	HEAT 3.|Necessary for HTLV-1 Rex-mediated mRNA export.|Interaction with Ran and nuclear export complex formation.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			TCAGTTTCTTCTACTTCAGAT	0.348													0	0	0	0.000602	0	4	36										T	61721193	C	T	61721193	3	4	54	1	0	0	0	0	1	0	0	0	17442	922	32	1	2190	1	XPO1	2	61721193	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	572230	61721193	181478180	172	14950										
B3GNT2	10678	broad.mit.edu	37	chr2	62450306	62450306	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tactccggccacctggccctGaggctgtaccatatcactga	9	15	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:62450306G>C	uc002sbs.2	+	2	1189	c.951G>C	c.(949-951)CTG>CTC	p.L317L		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	317	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			ACCTGGCCCTGAGGCTGTACC	0.522													0	0	0	0.004656	0	23	97										C	62450306	G	C	62450306	2	2	54	1	0	0	0	0	0	0	0	1	1257	1277	45	1		1	B3GNT2	2	62450306	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	729113	62450306	180749067	173	14951										
OTX1	5013	broad.mit.edu	37	chr2	63283012	63283012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacctcgtgtatgcagcgctCcgtagctgcaggcgccgcca	12	16	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:63283012C>T	uc002scd.2	+	5	874	c.626C>T	c.(625-627)TCC>TTC	p.S209F	OTX1_uc010ypt.1_Missense_Mutation_p.S143F	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	209						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					ATGCAGCGCTCCGTAGCTGCA	0.682													0	0	0	0.00308	0	7	36										T	63283012	C	T	63283012	3	4	54	1	0	0	0	0	1	0	0	0	11320	855	30	1	636	1	OTX1	2	63283012	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	832706	63283012	179916361	174	14952										
CEP68	23177	broad.mit.edu	37	chr2	65296855	65296855	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccaacagagagcccgtagctGagaggtctgagcctgcactc	12	13	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:65296855G>A	uc002sdl.3	+	2	491	c.277G>A	c.(277-279)GAG>AAG	p.E93K	CEP68_uc002sdj.2_Missense_Mutation_p.E93K|CEP68_uc010yqb.1_Missense_Mutation_p.E93K|CEP68_uc002sdk.3_Missense_Mutation_p.E93K|CEP68_uc010yqc.1_Missense_Mutation_p.E93K|CEP68_uc010yqd.1_Missense_Mutation_p.E93K	NM_015147	NP_055962	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	93					centrosome organization	centrosome				skin(1)	1						GCCCGTAGCTGAGAGGTCTGA	0.617													0	0	0	0.008291	0	9	80										A	65296855	G	A	65296855	3	1	54	1	0	0	0	0	1	0	0	0	3258	1291	45	1	279	1	CEP68	2	65296855	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2013843	65296855	177902518	175	14953										
PCYOX1	51449	broad.mit.edu	37	chr2	70485407	70485407	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgtgctccgccagataaaatCggtaggcgagaagggggcgg	17	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:70485407C>T	uc002sgn.3	+	1	177	c.111C>T	c.(109-111)ATC>ATT	p.I37I	PCYOX1_uc010fdo.2_Intron|PCYOX1_uc010yqu.1_Silent_p.I37I	NM_016297	NP_057381	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1 precursor	37					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			central_nervous_system(1)	1						CAGATAAAATCGGTAGGCGAG	0.607													0	0	0	0.001168	0	4	17										T	70485407	C	T	70485407	2	4	54	1	0	0	0	0	0	0	0	1	11608	898	31	1		1	PCYOX1	2	70485407	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5188552	70485407	172713966	176	14954										
NAGK	55577	broad.mit.edu	37	chr2	71302769	71302769	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggttttgccggaaaattgcaGaaggtactggaggtgggggg	19	4	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:71302769G>A	uc002shp.3	+	7	1070	c.664G>A	c.(664-666)GAA>AAA	p.E222K	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_Missense_Mutation_p.E73K|NAGK_uc002shr.2_Missense_Mutation_p.E171K	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	222					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	GAAAATTGCAGAAGGTACTGG	0.493													0	0	0	0.001368	0	10	56										A	71302769	G	A	71302769	3	1	54	1	0	0	0	0	1	0	0	0	10142	943	33	1	828	1	NAGK	2	71302769	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	817362	71302769	171896604	177	14955										
ALMS1	7840	broad.mit.edu	37	chr2	73799556	73799556	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaaagatttctttcagcatCatccagacaaacatagagaa	7	8	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:73799556C>T	uc002sje.1	+	18	10666	c.10555C>T	c.(10555-10557)CAT>TAT	p.H3519Y	ALMS1_uc002sjf.1_Missense_Mutation_p.H3475Y|ALMS1_uc002sjg.2_Missense_Mutation_p.H2905Y|ALMS1_uc002sjh.1_Missense_Mutation_p.H2905Y	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3517					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CTTTCAGCATCATCCAGACAA	0.383													0	0	0	0.001984	0	6	19										T	73799556	C	T	73799556	3	4	54	1	0	0	0	0	1	0	0	0	535	826	29	1	10611	1	ALMS1	2	73799556	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2496787	73799556	169399817	178	14956										
MOBKL1B	55233	broad.mit.edu	37	chr2	74399752	74399752	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attgagatcctctccctcagGcaacataacagcttgtctca	6	13	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:74399752G>A	uc002skh.3	-	2	336	c.142C>T	c.(142-144)CCT>TCT	p.P48S	MOBKL1B_uc002ski.2_Missense_Mutation_p.P48S	NM_018221	NP_060691	Q9H8S9	MOL1B_HUMAN	Mob4B protein	48					hippo signaling cascade		metal ion binding|protein binding				0						TCTCCCTCAGGCAACATAACA	0.373													0	0	0	0.006214	0	7	99										A	74399752	G	A	74399752	3	1	54	1	0	0	0	0	1	0	0	0	9683	1203	42	2	528	2	MOBKL1B	2	74399752	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	600196	74399752	168799621	179	14957										
WDR54	84058	broad.mit.edu	37	chr2	74650498	74650498	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggcatgcactggactctgGagatgcctccccaggtacct	11	14	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:74650498G>C	uc002slb.2	+	4	398	c.338G>C	c.(337-339)GGA>GCA	p.G113A		NM_032118	NP_115494	Q9H977	WDR54_HUMAN	WD repeat domain 54	113											0						CTGGACTCTGGAGATGCCTCC	0.552													0	0	0	0.00632	0	25	262										C	74650498	G	C	74650498	3	2	54	1	0	0	0	0	1	0	0	0	17303	1174	41	1	348	1	WDR54	2	74650498	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	250746	74650498	168548875	180	14958										
AUP1	550	broad.mit.edu	37	chr2	74756246	74756246	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccgtggcgctctcggcctCgctctcactcacggtgctac	10	19	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:74756246C>T	uc010yry.1	-	3	570	c.352G>A	c.(352-354)GAG>AAG	p.E118K	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Intron|AUP1_uc002smg.2_Intron|AUP1_uc002smh.2_5'UTR|AUP1_uc010yrx.1_Intron|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ58836, highly similar to Ancient ubiquitous protein 1;	118	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						CTCTCGGCCTCGCTCTCACTC	0.602													0	0	0	0.008291	0	8	51										T	74756246	C	T	74756246	3	4	54	1	0	0	0	0	1	0	0	0	1220	899	31	1		1	AUP1	2	74756246	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	105748	74756246	168443127	181	14959										
POLR1A	25885	broad.mit.edu	37	chr2	86255054	86255054	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaagctggtttcaaatgtCatctgctgtagcggggaaga	14	6	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:86255054C>T	uc002sqs.2	-	33	5395	c.5016G>A	c.(5014-5016)ATG>ATA	p.M1672I	POLR1A_uc010ytb.1_Missense_Mutation_p.M1038I	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1672					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TTTCAAATGTCATCTGCTGTA	0.542													0	0	0	0.001368	0	11	95										T	86255054	C	T	86255054	3	4	54	1	0	0	0	0	1	0	0	0	12209	826	29	1	154	1	POLR1A	2	86255054	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11498808	86255054	156944319	182	14960										
ADRA2B	151	broad.mit.edu	37	chr2	96780656	96780656	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgagctgttgcagtagccGatccagaagaagaactggaa	13	7	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:96780656G>A	uc002svi.2	-	3	1242	c.1242C>T	c.(1240-1242)ATC>ATT	p.I414I		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	414	Helical; Name=7; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TGCAGTAGCCGATCCAGAAGA	0.582													0	0	0	0.004672	0	3	28										A	96780656	G	A	96780656	2	1	54	1	0	0	0	0	0	0	0	1	338	1048	37	1		1	ADRA2B	2	96780656	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10525602	96780656	146418717	183	14961										
CIAO1	9391	broad.mit.edu	37	chr2	96932160	96932160	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgctgctggttcctggcctgGaaccccgcggggaccctgct	14	16	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:96932160G>A	uc002svs.2	+	1	277	c.72G>A	c.(70-72)TGG>TGA	p.W24*	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	24	WD 1.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						TCCTGGCCTGGAACCCCGCGG	0.741													0	0	0	0.004482	0	8	27										A	96932160	G	A	96932160	4	1	54	1	0	0	0	0	0	1	0	0	3418	1183	41	1	74	1	CIAO1	2	96932160	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	151504	96932160	146267213	184	14962										
NPAS2	4862	broad.mit.edu	37	chr2	101554280	101554280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctatgtctctgacagtatCacgcctctccttgggcattt	7	12	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:101554280C>T	uc002tap.1	+	5	625	c.339C>T	c.(337-339)ATC>ATT	p.I113I	NPAS2_uc010yvt.1_Silent_p.I178I	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	113	PAS 1.				central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						CTGACAGTATCACGCCTCTCC	0.453													0	0	0	0.00874	0	31	178										T	101554280	C	T	101554280	2	4	54	1	0	0	0	0	0	0	0	1	10563	816	29	1		1	NPAS2	2	101554280	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4622120	101554280	141645093	185	14963										
IL18RAP	8807	broad.mit.edu	37	chr2	103057804	103057804	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aactcaaaccagatattctgGatcctgtcgaggacacactg	8	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:103057804G>A	uc002tbx.2	+	7	1247	c.763G>A	c.(763-765)GAT>AAT	p.D255N	IL18RAP_uc010fiz.2_Missense_Mutation_p.D113N	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	255	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AGATATTCTGGATCCTGTCGA	0.418													0	0	0	0.009096	0	3	63										A	103057804	G	A	103057804	3	1	54	1	0	0	0	0	1	0	0	0	7648	1174	41	1	781	1	IL18RAP	2	103057804	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1503524	103057804	140141569	186	14964										
BUB1	699	broad.mit.edu	37	chr2	111419343	111419343	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgttcactggtgtctgctGataggttactggaagacatg	12	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:111419343G>C	uc002tgc.2	-	10	1145	c.1033C>G	c.(1033-1035)CAG>GAG	p.Q345E	BUB1_uc010yxh.1_Missense_Mutation_p.Q325E|BUB1_uc010fkb.2_Missense_Mutation_p.Q345E|BUB1_uc002tgd.2_Missense_Mutation_p.Q345E	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	345					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GGTGTCTGCTGATAGGTTACT	0.488													0	0	0	0.006214	0	7	95										C	111419343	G	C	111419343	3	2	54	1	0	0	0	0	1	0	0	0	1570	1299	45	1	2288	1	BUB1	2	111419343	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8361539	111419343	131780030	187	14965										
SLC20A1	6574	broad.mit.edu	37	chr2	113417184	113417184	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctgagatagacatgagtgtCaaggcagagatgggtctagg	15	5	3	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:113417184C>G	uc002tib.2	+	8	1898	c.1452C>G	c.(1450-1452)GTC>GTG	p.V484V	SLC20A1_uc002tic.1_Silent_p.V296V	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	484	Cytoplasmic (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						ACATGAGTGTCAAGGCAGAGA	0.463													0	0	0	0.012213	0	26	135										G	113417184	C	G	113417184	2	3	54	1	0	0	0	0	0	0	0	1	14438	813	29	1		1	SLC20A1	2	113417184	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1997841	113417184	129782189	188	14966										
IL1B	3553	broad.mit.edu	37	chr2	113593149	113593149	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acccatagtcttaccttcatCtgtttagggccatcagcttc	6	13	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:113593149C>T	uc002tii.1	-	3	180	c.93G>A	c.(91-93)CAG>CAA	p.Q31Q	IL1B_uc002tih.1_5'UTR	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	31					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	TTACCTTCATCTGTTTAGGGC	0.423													0	0	0	0.00308	0	6	61										T	113593149	C	T	113593149	2	4	54	1	0	0	0	0	0	0	0	1	7651	912	32	1		1	IL1B	2	113593149	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	175965	113593149	129606224	189	14967										
EN1	2019	broad.mit.edu	37	chr2	119600619	119600619	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgatgcctgtggctttcttGatcttggcgcgcttgttctg	12	9	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:119600619G>A	uc002tlm.2	-	2	2090	c.1074C>T	c.(1072-1074)ATC>ATT	p.I358I		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	358	Homeobox.				skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						TGGCTTTCTTGATCTTGGCGC	0.602													0	0	0	0.008291	0	10	62										A	119600619	G	A	119600619	2	1	54	1	0	0	0	0	0	0	0	1	5109	1280	45	1		1	EN1	2	119600619	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6007470	119600619	123598754	190	14968										
EN1	2019	broad.mit.edu	37	chr2	119604494	119604494	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaggcgccgcgagatgctGaggcggcgggggcggggggt	24	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:119604494G>C	uc002tlm.2	-	1	1266	c.250C>G	c.(250-252)CAG>GAG	p.Q84E		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	84					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GCGAGATGCTGAggcggcggg	0.363													0	0	0	0.00308	0	5	32										C	119604494	G	C	119604494	3	2	54	1	0	0	0	0	1	0	0	0	5109	1299	45	1	936	1	EN1	2	119604494	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3875	119604494	123594879	191	14969										
DBI	1622	broad.mit.edu	37	chr2	120125785	120125785	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgagtttgagaaagctgcaGaggaggttaggcaccttaag	14	6	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:120125785G>A	uc002tlv.2	+	2	155	c.31G>A	c.(31-33)GAG>AAG	p.E11K	C2orf76_uc002tls.2_5'Flank|C2orf76_uc010flf.1_5'Flank|C2orf76_uc010yyg.1_5'Flank|C2orf76_uc002tlt.2_5'Flank|C2orf76_uc002tlu.2_5'Flank|DBI_uc010yyh.1_Missense_Mutation_p.E28K|DBI_uc010yyi.1_Missense_Mutation_p.E28K|DBI_uc010yyj.1_RNA|DBI_uc010yyk.1_Missense_Mutation_p.E53K|DBI_uc010yyl.1_Missense_Mutation_p.E28K|DBI_uc010yym.1_Missense_Mutation_p.E21K|DBI_uc010yyn.1_Missense_Mutation_p.E28K|DBI_uc002tlw.2_Missense_Mutation_p.E28K|DBI_uc010yyo.1_RNA|DBI_uc002tlx.2_Missense_Mutation_p.E12K|DBI_uc010yyp.1_5'Flank	NM_001079862	NP_001073331	P07108	ACBP_HUMAN	diazepam binding inhibitor isoform 3	11	ACB.				transport		benzodiazepine receptor binding|fatty-acyl-CoA binding				0						GAAAGCTGCAGAGGAGGTTAG	0.502													0	0	0	0.003163	0	13	93										A	120125785	G	A	120125785	3	1	54	1	0	0	0	0	1	0	0	0	4251	943	33	1	343	1	DBI	2	120125785	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	521291	120125785	123073588	192	14970										
PTPN4	5775	broad.mit.edu	37	chr2	120684226	120684226	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaaagaaaaggcaaataaaGacagggtatttgcaaggtaa	11	4	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:120684226G>A	uc002tmf.1	+	13	1825	c.1054G>A	c.(1054-1056)GAC>AAC	p.D352N	PTPN4_uc010flj.1_Missense_Mutation_p.D65N	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	352						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	GGCAAATAAAGACAGGGTATT	0.284													0	0	0	0.001855	0	9	50										A	120684226	G	A	120684226	3	1	54	1	0	0	0	0	1	0	0	0	12790	942	33	1	1100	1	PTPN4	2	120684226	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	558441	120684226	122515147	193	14971										
FAM123C	205147	broad.mit.edu	37	chr2	131520311	131520311	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacctgttggacagcgagctCctggccgatgcatcctttgg	13	12	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:131520311C>G	uc002trw.2	+	2	856	c.666C>G	c.(664-666)CTC>CTG	p.L222L	FAM123C_uc010fmv.2_Silent_p.L222L|FAM123C_uc010fms.1_Silent_p.L222L|FAM123C_uc010fmt.1_Silent_p.L222L|FAM123C_uc010fmu.1_Silent_p.L222L	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	222										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		ACAGCGAGCTCCTGGCCGATG	0.677													0	0	0	0.004007	0	15	100										G	131520311	C	G	131520311	2	3	54	1	0	0	0	0	0	0	0	1	5424	842	30	1		1	FAM123C	2	131520311	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10836085	131520311	111679062	194	14972										
LRP1B	53353	broad.mit.edu	37	chr2	141093288	141093288	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctacgttgatagagtacctCagactggtccagtgagtagt	11	9	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:141093288C>T	uc002tvj.1	-	78	12984	c.12012G>A	c.(12010-12012)CTG>CTA	p.L4004L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4004	Extracellular (Potential).|LDL-receptor class B 34.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAGAGTACCTCAGACTGGTCC	0.458										TSP Lung(27;0.18)			0	0	0	0.006214	0	8	33										T	141093288	C	T	141093288	2	4	54	1	0	0	0	0	0	0	0	1	8955	813	29	1		1	LRP1B	2	141093288	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	9572977	141093288	102106085	195	14973										
MBD5	55777	broad.mit.edu	37	chr2	149270460	149270460	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacaccaaatcccacagggtGacagacaaatgagacccccc	7	15	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:149270460G>A	uc002twm.3	+	15	5423	c.4435G>A	c.(4435-4437)GAC>AAC	p.D1479N	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.D1479N|MBD5_uc002two.2_Missense_Mutation_p.D737N|MBD5_uc002twp.2_Missense_Mutation_p.D529N	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1479						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CCCACAGGGTGACAGACAAAT	0.408													0	0	0	0.001168	0	5	73										A	149270460	G	A	149270460	3	1	54	1	0	0	0	0	1	0	0	0	9347	1290	45	1	4473	1	MBD5	2	149270460	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8177172	149270460	93928913	196	14974										
NEB	4703	broad.mit.edu	37	chr2	152362007	152362007	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actaccgagctaatgtgcttCtgcgtctccttcacacgttt	7	13	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:152362007C>G	uc010fnx.2	-	137	18815	c.18624G>C	c.(18622-18624)CAG>CAC	p.Q6208H	NEB_uc002txr.2_Missense_Mutation_p.Q2631H|RIF1_uc002txp.2_Intron|NEB_uc002txq.2_5'Flank|NEB_uc010zca.1_Missense_Mutation_p.Q39H|NEB_uc010zcb.1_Missense_Mutation_p.Q39H|NEB_uc002txt.3_Missense_Mutation_p.Q713H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6208	Nebulin 170.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TAATGTGCTTCTGCGTCTCCT	0.468													0	0	0	0.002299	0	20	116										G	152362007	C	G	152362007	3	3	54	1	0	0	0	0	1	0	0	0	10302	912	32	1	1922	1	NEB	2	152362007	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3091547	152362007	90837366	197	14975										
STAM2	10254	broad.mit.edu	37	chr2	153003708	153003708	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaggaaaagtaattccttCttctttcatagatttaatag	7	5	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:153003708C>T	uc002tyc.3	-	5	765	c.415G>A	c.(415-417)GAA>AAA	p.E139K	STAM2_uc010foa.1_Missense_Mutation_p.E139K|STAM2_uc002tyd.2_Missense_Mutation_p.E139K	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	139	VHS.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		GTAATTCCTTCTTCTTTCATA	0.358													0	0	0	0.000602	0	4	58										T	153003708	C	T	153003708	3	4	54	1	0	0	0	0	1	0	0	0	15248	922	32	1	1202	1	STAM2	2	153003708	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	641701	153003708	90195665	198	14976										
BAZ2B	29994	broad.mit.edu	37	chr2	160289391	160289391	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggaatgtctgaatctgttcCtctgaattgttccactaaag	9	8	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:160289391C>T	uc002uao.2	-	9	2129	c.1777G>A	c.(1777-1779)GGA>AGA	p.G593R	BAZ2B_uc002uap.2_Missense_Mutation_p.G591R|BAZ2B_uc002uas.1_Missense_Mutation_p.G530R|BAZ2B_uc002uaq.1_Missense_Mutation_p.G521R|BAZ2B_uc002uar.1_Missense_Mutation_p.G166R	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GAATCTGTTCCTCTGAATTGT	0.279													0	0	0	0.003163	0	16	82										T	160289391	C	T	160289391	3	4	54	1	0	0	0	0	1	0	0	0	1332	690	24	2	4845	2	BAZ2B	2	160289391	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7285683	160289391	82909982	199	14977										
LY75	4065	broad.mit.edu	37	chr2	160667045	160667045	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attttaactcaccatgttttGaacacaattttttggcctct	4	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:160667045G>C	uc002ubc.3	-	32	4760	c.4691C>G	c.(4690-4692)TCA>TGA	p.S1564*	LY75_uc002ubb.3_Nonsense_Mutation_p.S1564*|LY75_uc010fos.2_Nonsense_Mutation_p.S1564*	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1564	Extracellular (Potential).|C-type lectin 10.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		ACCATGTTTTGAACACAATTT	0.254													0	0	0	0.006122	0	15	129										C	160667045	G	C	160667045	4	2	54	1	0	0	0	0	0	1	0	0	9099	1294	45	1	493	1	LY75	2	160667045	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	377654	160667045	82532328	200	14978										
PLA2R1	22925	broad.mit.edu	37	chr2	160832638	160832638	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaatgaattgtgagaagatCactgtgcagccagctacaga	11	7	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:160832638C>T	uc002ube.1	-	17	2743	c.2536G>A	c.(2536-2538)GAT>AAT	p.D846N	PLA2R1_uc010zcp.1_Missense_Mutation_p.D846N|PLA2R1_uc002ubf.2_Missense_Mutation_p.D846N	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	846	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GTGAGAAGATCACTGTGCAGC	0.403													0	0	0	0.00308	0	7	61										T	160832638	C	T	160832638	3	4	54	1	0	0	0	0	1	0	0	0	12010	826	29	1	1919	1	PLA2R1	2	160832638	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	165593	160832638	82366735	201	14979										
PLA2R1	22925	broad.mit.edu	37	chr2	160869838	160869838	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaagcttggtcaaagcttcGaaggactgtgtcaattttgt	12	6	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:160869838G>A	uc002ube.1	-	10	1807	c.1600C>T	c.(1600-1602)CGA>TGA	p.R534*	PLA2R1_uc010zcp.1_Nonsense_Mutation_p.R534*|PLA2R1_uc002ubf.2_Nonsense_Mutation_p.R534*	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	534	Extracellular (Potential).|C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TCAAAGCTTCGAAGGACTGTG	0.368													0	0	0	0.001368	0	8	49										A	160869838	G	A	160869838	4	1	54	1	0	0	0	0	0	1	0	0	12010	1066	37	1	2883	1	PLA2R1	2	160869838	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	37200	160869838	82329535	202	14980										
PLA2R1	22925	broad.mit.edu	37	chr2	160889477	160889477	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccacctacttaccccttatGaaattttcttcagtttcatc	2	13	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:160889477G>C	uc002ube.1	-	4	1041	c.834C>G	c.(832-834)TTC>TTG	p.F278L	PLA2R1_uc010zcp.1_Missense_Mutation_p.F278L|PLA2R1_uc002ubf.2_Missense_Mutation_p.F278L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	278	Extracellular (Potential).|C-type lectin 1.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TACCCCTTATGAAATTTTCTT	0.358													0	0	0	0.004656	0	18	123										C	160889477	G	C	160889477	3	2	54	1	0	0	0	0	1	0	0	0	12010	1281	45	1	3673	1	PLA2R1	2	160889477	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	19639	160889477	82309896	203	14981										
RBMS1	5937	broad.mit.edu	37	chr2	161141534	161141534	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tatagcagctgtagttgggtCgtaagtaagtgtcattccag	12	6	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:161141534C>T	uc002ubo.2	-	8	1222	c.778G>A	c.(778-780)GAC>AAC	p.D260N	RBMS1_uc002ubj.2_Missense_Mutation_p.D224N|RBMS1_uc002ubk.2_Missense_Mutation_p.D224N|RBMS1_uc002ubl.2_Missense_Mutation_p.D255N|RBMS1_uc002ubn.2_Missense_Mutation_p.D257N|RBMS1_uc002ubi.3_Missense_Mutation_p.D257N|RBMS1_uc002ubm.2_Missense_Mutation_p.D227N|RBMS1_uc002ubp.2_Missense_Mutation_p.D260N|RBMS1_uc010fox.2_Missense_Mutation_p.D260N	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	260					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						GTAGTTGGGTCGTAAGTAAGT	0.323													0	0	0	0.010729	0	9	57										T	161141534	C	T	161141534	3	4	54	1	0	0	0	0	1	0	0	0	13148	884	31	1	466	1	RBMS1	2	161141534	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	252057	161141534	82057839	204	14982										
FIGN	55137	broad.mit.edu	37	chr2	164466154	164466154	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aatcttgcagaaagcattttCaaagtcttgatatgtaacgg	8	6	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:164466154C>T	uc002uck.1	-	3	2499	c.2188G>A	c.(2188-2190)GAA>AAA	p.E730K		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	730						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						AAAGCATTTTCAAAGTCTTGA	0.463													0	0	0	0.001984	0	6	52										T	164466154	C	T	164466154	3	4	54	1	0	0	0	0	1	0	0	0	5891	835	29	1	95	1	FIGN	2	164466154	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3324620	164466154	78733219	205	14983										
TTC21B	79809	broad.mit.edu	37	chr2	166797590	166797590	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcaaggctagttgtaatttCattttcttaacaaaagcagg	8	6	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:166797590C>T	uc002udk.2	-	6	790	c.657G>A	c.(655-657)ATG>ATA	p.M219I	TTC21B_uc002udl.2_Missense_Mutation_p.M219I|uc002udm.1_Intron	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	219						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						GTTGTAATTTCATTTTCTTAA	0.403													0	0	0	0.000602	0	4	21										T	166797590	C	T	166797590	3	4	54	1	0	0	0	0	1	0	0	0	16685	826	29	1	3389	1	TTC21B	2	166797590	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2331436	166797590	76401783	206	14984										
HOXD13	3239	broad.mit.edu	37	chr2	176958257	176958257	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcgacatggtgtccactttCggctccggggagcctcggca	13	13	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:176958257C>T	uc002ukf.1	+	1	726	c.639C>T	c.(637-639)TTC>TTT	p.F213F		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	213					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		TGTCCACTTTCGGCTCCGGGG	0.617			T	NUP98	AML*								0	0	0	0.001855	0	10	142										T	176958257	C	T	176958257	2	4	54	1	0	0	0	0	0	0	0	1	7322	883	31	1		1	HOXD13	2	176958257	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10160667	176958257	66241116	207	14985										
HOXD4	3233	broad.mit.edu	37	chr2	177016457	177016457	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcggctacctaggcgagcaGggcgccgactactacggcgg	17	13	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:177016457G>A	uc002uks.2	+	1	345	c.96G>A	c.(94-96)CAG>CAA	p.Q32Q		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	32						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		TAGGCGAGCAGGGCGCCGACT	0.627													0	0	0	0.008291	0	8	71										A	177016457	G	A	177016457	2	1	54	1	0	0	0	0	0	0	0	1	7324	991	35	2		2	HOXD4	2	177016457	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	58200	177016457	66182916	208	14986										
TTC30A	92104	broad.mit.edu	37	chr2	178482268	178482268	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtgagtctccgaagctgctCagtcagcatccctgctagcc	11	14	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:178482268C>G	uc002ulo.2	-	1	1427	c.1162G>C	c.(1162-1164)GAG>CAG	p.E388Q		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	388					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CGAAGCTGCTCAGTCAGCATC	0.463													0	0	0	0.008871	0	18	129										G	178482268	C	G	178482268	3	3	54	1	0	0	0	0	1	0	0	0	16695	835	29	1	839	1	TTC30A	2	178482268	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1465811	178482268	64717105	209	14987										
TTC30A	92104	broad.mit.edu	37	chr2	178482343	178482343	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggcaagtgatcagggcatCtaagaagtcatagagatagg	13	6	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:178482343C>G	uc002ulo.2	-	1	1352	c.1087G>C	c.(1087-1089)GAT>CAT	p.D363H		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	363					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			ATCAGGGCATCTAAGAAGTCA	0.473													0	0	0	0.006122	0	16	99										G	178482343	C	G	178482343	3	3	54	1	0	0	0	0	1	0	0	0	16695	913	32	1	914	1	TTC30A	2	178482343	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	75	178482343	64717030	210	14988										
TTN	7273	broad.mit.edu	37	chr2	179489391	179489391	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctctggagacttcacactcCagcactgcagtggctccctc	8	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:179489391C>T	uc010zfg.1	-	191	37136	c.36912G>A	c.(36910-36912)CTG>CTA	p.L12304L	TTN_uc010zfh.1_Silent_p.L5999L|TTN_uc010zfi.1_Silent_p.L5932L|TTN_uc010zfj.1_Silent_p.L5807L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13231							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCACACTCCAGCACTGCAG	0.458													0	0	0	0.004672	0	3	13										T	179489391	C	T	179489391	2	4	54	1	0	0	0	0	0	0	0	1	16732	581	21	2		2	TTN	2	179489391	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1007048	179489391	63709982	211	14989										
TTN	7273	broad.mit.edu	37	chr2	179594559	179594559	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgttatttcattcccgtctaGataccaagacactcggattt	6	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:179594559G>C	uc010zfg.1	-	60	14913	c.14689C>G	c.(14689-14691)CTA>GTA	p.L4897V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L1558V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5824							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCCGTCTAGATACCAAGAC	0.428													0	0	0	0.000602	0	4	27										C	179594559	G	C	179594559	3	2	54	1	0	0	0	0	1	0	0	0	16732	933	33	1	86308	1	TTN	2	179594559	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	105168	179594559	63604814	212	14990										
GTF3C3	9330	broad.mit.edu	37	chr2	197664281	197664281	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctccgccgttcgaactcctCaaaggagattttcccttcca	6	15	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:197664281C>G	uc002uts.2	-	1	145	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	GTF3C3_uc010zgu.1_Missense_Mutation_p.E19Q|GTF3C3_uc002utu.2_Missense_Mutation_p.E19Q	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	19						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						TCGAACTCCTCAAAGGAGATT	0.527													0	0	0	0.012319	0	13	91										G	197664281	C	G	197664281	3	3	54	1	0	0	0	0	1	0	0	0	6874	835	29	1	2677	1	GTF3C3	2	197664281	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	18069722	197664281	45535092	213	14991										
SF3B1	23451	broad.mit.edu	37	chr2	198263234	198263234	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaattctcttgtactttttCatgtctgttctttaagatgg	6	7	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:198263234C>T	uc002uue.2	-	21	3133	c.3085G>A	c.(3085-3087)GAA>AAA	p.E1029K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	1029	HEAT 8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTACTTTTTCATGTCTGTTC	0.343													0	0	0	0.002299	0	17	94										T	198263234	C	T	198263234	3	4	54	1	0	0	0	0	1	0	0	0	14149	835	29	1	849	1	SF3B1	2	198263234	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	598953	198263234	44936139	214	14992										
FZD7	8324	broad.mit.edu	37	chr2	202900897	202900897	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggctcctgcagacgtgcaaGagctatgccgtgccctgccc	12	15	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:202900897G>C	uc002uyw.1	+	1	1588	c.1527G>C	c.(1525-1527)AAG>AAC	p.K509N		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	509	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						AGACGTGCAAGAGCTATGCCG	0.627											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	20	125										C	202900897	G	C	202900897	3	2	54	1	0	0	0	0	1	0	0	0	6135	933	33	1	1529	1	FZD7	2	202900897	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4637663	202900897	40298476	215	14993										
NBEAL1	65065	broad.mit.edu	37	chr2	204078320	204078320	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccaaagaatacagccatattCttgtaggtttagaagatggc	9	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:204078320C>G	uc002uzt.3	+	54	8260	c.7927C>G	c.(7927-7929)CTT>GTT	p.L2643V	NBEAL1_uc002uzs.3_Missense_Mutation_p.L1284V|NBEAL1_uc002uzu.2_Missense_Mutation_p.L138V	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2643							binding			ovary(1)|skin(1)	2						CAGCCATATTCTTGTAGGTTT	0.398													0	0	0	0.00874	0	30	115										G	204078320	C	G	204078320	3	3	54	1	0	0	0	0	1	0	0	0	10188	913	32	1	8137	1	NBEAL1	2	204078320	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1177423	204078320	39121053	216	14994										
INO80D	54891	broad.mit.edu	37	chr2	206870253	206870253	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttgggaggaggtctccattCttccctgagtcaacaaaagc	11	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:206870253C>G	uc002vaz.3	-	11	2328	c.1923G>C	c.(1921-1923)AAG>AAC	p.K641N		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	641					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GGTCTCCATTCTTCCCTGAGT	0.443													0	0	0	0.009096	0	4	21										G	206870253	C	G	206870253	3	3	54	1	0	0	0	0	1	0	0	0	7749	912	32	1	1164	1	INO80D	2	206870253	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2791933	206870253	36329120	217	14995										
SMARCAL1	50485	broad.mit.edu	37	chr2	217300156	217300156	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctggcctgatcaacattgtCagctttgaccttcttagcaa	8	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:217300156C>T	uc002vgc.3	+	9	1911	c.1581C>T	c.(1579-1581)GTC>GTT	p.V527V	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Silent_p.V527V|SMARCAL1_uc010fvg.2_Silent_p.V527V	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	527	Helicase ATP-binding.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		TCAACATTGTCAGCTTTGACC	0.463									Schimke_Immuno-Osseous_Dysplasia				0	0	0	0.001984	0	6	60										T	217300156	C	T	217300156	2	4	54	1	0	0	0	0	0	0	0	1	14773	813	29	1		1	SMARCAL1	2	217300156	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10429903	217300156	25899217	218	14996										
CCDC108	255101	broad.mit.edu	37	chr2	219896248	219896248	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaaaaggcctcagtcgtatCtcccacagcacacatgggca	9	13	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:219896248C>T	uc002vjl.1	-	7	862	c.778G>A	c.(778-780)GAT>AAT	p.D260N	CCDC108_uc010fwa.1_5'Flank|CCDC108_uc010zkp.1_Missense_Mutation_p.D249N|CCDC108_uc010zkq.1_Missense_Mutation_p.D195N	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	260						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAGTCGTATCTCCCACAGCA	0.627													0	0	0	0.00361	0	39	328										T	219896248	C	T	219896248	3	4	54	1	0	0	0	0	1	0	0	0	2743	913	32	1	5115	1	CCDC108	2	219896248	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2596092	219896248	23303125	219	14997										
ALPP	250	broad.mit.edu	37	chr2	233243989	233243989	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggggcctgagatacccctGgccatggaccgcttcccata	11	15	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:233243989G>A	uc002vsq.2	+	3	438	c.273G>A	c.(271-273)CTG>CTA	p.L91L	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	91						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		AGATACCCCTGGCCATGGACC	0.552													0	0	0	0.004482	0	7	54										A	233243989	G	A	233243989	2	1	54	1	0	0	0	0	0	0	0	1	548	1335	47	2		2	ALPP	2	233243989	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	13347741	233243989	9955384	220	14998										
GIGYF2	26058	broad.mit.edu	37	chr2	233599920	233599920	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaaaagaatggcagcggaaAcgcagacactgaactttggg	14	7	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:233599920A>G	uc002vti.3	+	5	350	c.13A>G	c.(13-15)ACG>GCG	p.T5A	GIGYF2_uc002vte.2_RNA|GIGYF2_uc002vtf.2_RNA|GIGYF2_uc010zmj.1_Missense_Mutation_p.T5A|GIGYF2_uc002vtg.2_Missense_Mutation_p.T5A|GIGYF2_uc002vtj.3_Missense_Mutation_p.T5A|GIGYF2_uc002vtk.3_Missense_Mutation_p.T5A|GIGYF2_uc002vth.3_Missense_Mutation_p.T5A|GIGYF2_uc002vtl.2_RNA|GIGYF2_uc010zmk.1_RNA	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	5					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GGCAGCGGAAACGCAGACACT	0.333													0	0	0	0.001984	0	4	29										G	233599920	A	G	233599920	3	3	54	1	0	0	0	0	1	0	0	0	6378	43	2	5	15	5	GIGYF2	2	233599920	Missense_Mutation	SNP	A	TCGA-DK-A2I4-01A-11D-A21A-08	355931	233599920	9599453	221	14999										
MLPH	79083	broad.mit.edu	37	chr2	238402155	238402155	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcaacgagattttgacctccGaaggaaagaagaggaacggc	12	8	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:238402155G>A	uc002vwt.2	+	2	313	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	MLPH_uc002vws.2_Missense_Mutation_p.R29Q|MLPH_uc010fyt.1_Missense_Mutation_p.R29Q|MLPH_uc002vwu.2_Missense_Mutation_p.R29Q|MLPH_uc002vwv.2_Missense_Mutation_p.R29Q	NM_024101	NP_077006	Q9BV36	MELPH_HUMAN	melanophilin isoform 1	29	RabBD.						metal ion binding			ovary(1)	1		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		TTTGACCTCCGAAGGAAAGAA	0.542													0	0	0	0.00499	0	16	99										A	238402155	G	A	238402155	3	1	54	1	0	0	0	0	1	0	0	0	9633	1058	37	1	88	1	MLPH	2	238402155	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4802235	238402155	4797218	222	15000										
GPC1	2817	broad.mit.edu	37	chr2	241398601	241398601	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccacccagctgcgcagcttCgatggtgagtgcctcccacg	12	16	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:241398601C>T	uc002vyw.3	+	2	542	c.321C>T	c.(319-321)TTC>TTT	p.F107F	PP14571_uc002vyy.1_5'Flank	NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	107					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		TGCGCAGCTTCGATGGTGAGT	0.701													0	0	0	0.004482	0	7	28										T	241398601	C	T	241398601	2	4	54	1	0	0	0	0	0	0	0	1	6597	883	31	1		1	GPC1	2	241398601	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2996446	241398601	1800772	223	15001										
GAL3ST2	64090	broad.mit.edu	37	chr2	242743447	242743447	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acatcctgggttacaacctcCggccgggcctggacaaccag	11	15	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr2:242743447C>T	uc002wcj.1	+	4	1194	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	355	Lumenal (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTACAACCTCCGGCCGGGCCT	0.667													0	0	0	0.00308	0	5	11										T	242743447	C	T	242743447	3	4	54	1	0	0	0	0	1	0	0	0	6198	643	23	2	1077	2	GAL3ST2	2	242743447	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1344846	242743447	455926	224	15002										
ATG7	10533	broad.mit.edu	37	chr3	11404346	11404346	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtcgtccaggactggccgtGattgcaggagccctggccgt	15	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:11404346G>A	uc003bwc.2	+	15	1860	c.1743G>A	c.(1741-1743)GTG>GTA	p.V581V	ATG7_uc003bwd.2_Silent_p.V581V|ATG7_uc011aum.1_Silent_p.V542V	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	581					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						GACTGGCCGTGATTGCAGGAG	0.488													0	0	0	0.004482	0	8	73										A	11404346	G	A	11404346	2	1	54	1	0	0	0	0	0	0	0	1	1101	1277	45	1		1	ATG7	3	11404346	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		11404346	186618084	225	15003										
NUP210	23225	broad.mit.edu	37	chr3	13401905	13401905	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaagaatttggacggctcGaggatccaaggtctgggacc	15	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:13401905G>A	uc003bxv.1	-	15	2102	c.2019C>T	c.(2017-2019)CTC>CTT	p.L673L	NUP210_uc003bxx.2_Silent_p.L345L	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	673	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TGGACGGCTCGAGGATCCAAG	0.562													0	0	0	0.00623	0	37	40										A	13401905	G	A	13401905	2	1	54	1	0	0	0	0	0	0	0	1	10760	1045	37	1		1	NUP210	3	13401905	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1997559	13401905	184620525	226	15004										
SLC6A6	6533	broad.mit.edu	37	chr3	14509714	14509714	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggacattgctgatgtggctGagtcaggtacggtggtatcg	16	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:14509714G>A	uc010heg.2	+	16	1381	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	SLC6A6_uc003byq.2_Missense_Mutation_p.E364K|SLC6A6_uc003byr.2_Intron	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	364					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						TGATGTGGCTGAGTCAGGTAC	0.547											OREG0015421	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	25										A	14509714	G	A	14509714	3	1	54	1	0	0	0	0	1	0	0	0	14688	1291	45	1	1120	1	SLC6A6	3	14509714	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1107809	14509714	183512716	227	15005										
COLQ	8292	broad.mit.edu	37	chr3	15512080	15512080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggtcttcctgtgggtcctCggtgtcctgctatcccaggt	12	13	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:15512080C>T	uc003bzx.2	-	11	806	c.680G>A	c.(679-681)CGA>CAA	p.R227Q	COLQ_uc003bzv.2_Missense_Mutation_p.R217Q|COLQ_uc003bzz.2_Missense_Mutation_p.R218Q|COLQ_uc010heo.2_Missense_Mutation_p.R193Q|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Missense_Mutation_p.R86Q|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	227	Collagen-like 1.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						TGTGGGTCCTCGGTGTCCTGC	0.552													0	0	0	0.009535	0	24	83										T	15512080	C	T	15512080	3	4	54	1	0	0	0	0	1	0	0	0	3713	884	31	1	715	1	COLQ	3	15512080	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1002366	15512080	182510350	228	15006										
DPH3	285381	broad.mit.edu	37	chr3	16306335	16306335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaatacgtctccgagtcctCgtcatattggaagtcctcga	9	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:16306335C>T	uc003cau.2	-	1	162	c.49G>A	c.(49-51)GAG>AAG	p.E17K	DPH3_uc003cat.3_5'Flank|DPH3_uc003cav.2_Missense_Mutation_p.E17K|OXNAD1_uc010her.1_5'Flank|OXNAD1_uc003caw.2_5'Flank|OXNAD1_uc003cax.2_5'Flank	NM_206831	NP_996662	Q96FX2	DPH3_HUMAN	zinc finger, CSL domain containing 2 isoform 1	17	DPH-type.				negative regulation of protein secretion|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of binding	cytoplasm|nucleus	metal ion binding|protein binding				0						TCCGAGTCCTCGTCATATTGG	0.582													0	0	0	0.000602	0	4	83										T	16306335	C	T	16306335	3	4	54	1	0	0	0	0	1	0	0	0	4721	893	31	1	211	1	DPH3	3	16306335	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	794255	16306335	181716095	229	15007										
NGLY1	55768	broad.mit.edu	37	chr3	25805781	25805781	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccactgaagcttttttagGaaagatgagatgtgtttctc	9	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:25805781G>A	uc003cdl.2	-	3	376	c.268C>T	c.(268-270)CCT>TCT	p.P90S	NGLY1_uc010hfg.2_Missense_Mutation_p.P90S|NGLY1_uc003cdm.2_Missense_Mutation_p.P90S|NGLY1_uc011awo.1_Missense_Mutation_p.P48S|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	90	PUB.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						GCTTTTTTAGGAAAGATGAGA	0.373													0	0	0	0.010729	0	10	92										A	25805781	G	A	25805781	3	1	54	1	0	0	0	0	1	0	0	0	10398	1174	41	1	1832	1	NGLY1	3	25805781	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9499446	25805781	172216649	230	15008										
NEK10	152110	broad.mit.edu	37	chr3	27333022	27333022	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcttcataagcactgatatCacgtacataatgccctatgt	5	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:27333022C>T	uc003cdt.1	-	18	1703	c.1429G>A	c.(1429-1431)GAT>AAT	p.D477N	NEK10_uc003cds.1_5'UTR	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	477							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GCACTGATATCACGTACATAA	0.373													0	0	0	0.004482	0	7	36										T	27333022	C	T	27333022	3	4	54	1	0	0	0	0	1	0	0	0	10322	826	29	1	741	1	NEK10	3	27333022	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1527241	27333022	170689408	231	15009										
FBXL2	25827	broad.mit.edu	37	chr3	33414612	33414612	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacagaactgccgaaacattGaacatttgaacctcaatgga	7	10	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:33414612G>A	uc003cfp.2	+	6	390	c.319G>A	c.(319-321)GAA>AAA	p.E107K	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_5'UTR|FBXL2_uc011axp.1_Missense_Mutation_p.E23K|FBXL2_uc011axq.1_RNA|FBXL2_uc011axr.1_RNA|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	107	LRR 2.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						CCGAAACATTGAACATTTGAA	0.423													0	0	0	0.00361	0	48	112										A	33414612	G	A	33414612	3	1	54	1	0	0	0	0	1	0	0	0	5716	1291	45	1	341	1	FBXL2	3	33414612	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6081590	33414612	164607818	232	15010										
CLASP2	23122	broad.mit.edu	37	chr3	33558526	33558526	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caatattgttttgaagtgttCatcccaaacactaaaagatt	5	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:33558526C>T	uc003cfu.2	-	34	4282	c.3928G>A	c.(3928-3930)GAA>AAA	p.E1310K	CLASP2_uc003cfs.2_Missense_Mutation_p.E517K|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.E910K	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1319										ovary(3)|central_nervous_system(1)	4						TTGAAGTGTTCATCCCAAACA	0.363													0	0	0	0.00333	0	16	58										T	33558526	C	T	33558526	3	4	54	1	0	0	0	0	1	0	0	0	3455	835	29	1	612	1	CLASP2	3	33558526	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	143914	33558526	164463904	233	15011										
CSPG5	10675	broad.mit.edu	37	chr3	47619161	47619161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctggaagggcctgggcatCgccgctgcccgcctctgcgg	16	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:47619161C>T	uc003crp.3	-	2	531	c.355G>A	c.(355-357)GAT>AAT	p.D119N	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Missense_Mutation_p.D119N|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	119	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCTGGGCATCGCCGCTGCCC	0.692													0	0	0	0.00361	0	50	88										T	47619161	C	T	47619161	3	4	54	1	0	0	0	0	1	0	0	0	3961	884	31	1	1280	1	CSPG5	3	47619161	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	14060635	47619161	150403269	234	15012										
MAP4	4134	broad.mit.edu	37	chr3	47958225	47958225	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccatgtccttggaaggggcTaagtccatttttataggaga	11	8	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:47958225T>C	uc003csb.2	-	7	1618	c.1092A>G	c.(1090-1092)TTA>TTG	p.L364L	MAP4_uc003csc.3_Silent_p.L364L|MAP4_uc011bbf.1_Silent_p.L341L|MAP4_uc003csf.3_Silent_p.L381L	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	364	26 residues 1.|17 X 14 AA tandem repeats.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGAAGGGGCTAAGTCCATTT	0.478													0	0	0	0.004672	0	3	119										C	47958225	T	C	47958225	2	2	54	1	0	0	0	0	0	0	0	1	9258	1519	53	5		5	MAP4	3	47958225	Silent	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	339064	47958225	150064205	235	15013										
IP6K2	51447	broad.mit.edu	37	chr3	48726994	48726994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgccacacacacgcacacCaatgactgcagatgtgctct	7	15	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:48726994C>T	uc003cup.2	-	5	1001	c.757G>A	c.(757-759)GGT>AGT	p.G253S	IP6K2_uc003cuq.2_Missense_Mutation_p.G253S	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	253					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						ACACGCACACCAATGACTGCA	0.547													0	0	0	0.003271	0	25	125										T	48726994	C	T	48726994	3	4	54	1	0	0	0	0	1	0	0	0	7789	594	21	2	531	2	IP6K2	3	48726994	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	768769	48726994	149295436	236	15014										
P4HTM	54681	broad.mit.edu	37	chr3	49039971	49039971	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgggaaatggatggtggatGactccagagagcattcagga	15	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:49039971G>A	uc003cvg.2	+	4	1015	c.666G>A	c.(664-666)ATG>ATA	p.M222I	P4HTM_uc003cvh.2_Missense_Mutation_p.M222I|P4HTM_uc010hkm.1_Missense_Mutation_p.M108I	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	222	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	GATGGTGGATGACTCCAGAGA	0.577													0	0	0	0.00361	0	66	222										A	49039971	G	A	49039971	3	1	54	1	0	0	0	0	1	0	0	0	11360	1290	45	1	680	1	P4HTM	3	49039971	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	312977	49039971	148982459	237	15015										
SEMA3F	6405	broad.mit.edu	37	chr3	50214234	50214234	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctggagcctgagcgactcGagtcagggaagggcaagtgt	16	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:50214234G>A	uc003cyj.2	+	7	781	c.583G>A	c.(583-585)GAG>AAG	p.E195K	SEMA3F_uc003cyk.2_Missense_Mutation_p.E164K	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	195	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		TGAGCGACTCGAGTCAGGGAA	0.597													0	0	0	0.004656	0	19	263										A	50214234	G	A	50214234	3	1	54	1	0	0	0	0	1	0	0	0	14029	1059	37	1	605	1	SEMA3F	3	50214234	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1174263	50214234	147808196	238	15016										
HYAL3	8372	broad.mit.edu	37	chr3	50331093	50331093	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagaggctcaggtccccccaGagcaccacgccggctgcccc	12	19	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:50331093G>C	uc003czd.1	-	3	1227	c.954C>G	c.(952-954)CTC>CTG	p.L318L	HYAL3_uc003czc.1_Intron|HYAL3_uc003cze.1_Silent_p.L69L|HYAL3_uc003czf.1_Intron|HYAL3_uc003czg.1_Intron|IFRD2_uc011bdp.1_5'Flank|IFRD2_uc003czb.2_5'Flank	NM_003549	NP_003540	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3 precursor	318					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGTCCCCCCAGAGCACCACGC	0.632													0	0	0	0.00361	0	56	169										C	50331093	G	C	50331093	2	2	54	1	0	0	0	0	0	0	0	1	7465	929	33	1		1	HYAL3	3	50331093	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	116859	50331093	147691337	239	15017										
STAB1	23166	broad.mit.edu	37	chr3	52557550	52557550	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cactcaggcctcagcctcatCatcagtgacgcaggccctga	9	16	5	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:52557550C>T	uc003dej.2	+	65	7322	c.7248C>T	c.(7246-7248)ATC>ATT	p.I2416I	STAB1_uc003dek.1_Silent_p.I431I|STAB1_uc003del.2_Silent_p.I303I	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2416	Extracellular (Potential).|FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCAGCCTCATCATCAGTGACG	0.647													0	0	0	0.010504	0	17	57										T	52557550	C	T	52557550	2	4	54	1	0	0	0	0	0	0	0	1	15236	816	29	1		1	STAB1	3	52557550	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2226457	52557550	145464880	240	15018										
CACNA1D	776	broad.mit.edu	37	chr3	53844150	53844150	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgatccaagtggagcagtCagaggccctggaccaggtga	14	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:53844150C>G	uc003dgv.3	+	47	6180	c.6017C>G	c.(6016-6018)TCA>TGA	p.S2006*	CACNA1D_uc003dgu.3_Nonsense_Mutation_p.S2026*|CACNA1D_uc003dgy.3_Nonsense_Mutation_p.S1982*|CACNA1D_uc003dgw.3_Nonsense_Mutation_p.S1673*|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	2006	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GTGGAGCAGTCAGAGGCCCTG	0.657													0	0	0	0.001984	0	6	83										G	53844150	C	G	53844150	4	3	54	1	0	0	0	0	0	1	0	0	2541	838	29	1	6375	1	CACNA1D	3	53844150	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1286600	53844150	144178280	241	15019										
C3orf63	23272	broad.mit.edu	37	chr3	56657229	56657229	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggtgtccccaaaaatgtctGatgagtgagaacattaaaat	9	6	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:56657229G>C	uc003did.3	-	23	4767	c.4666C>G	c.(4666-4668)CAG>GAG	p.Q1556E	C3orf63_uc003dib.3_Missense_Mutation_p.Q675E|C3orf63_uc003dic.3_Missense_Mutation_p.Q1180E|C3orf63_uc003die.3_3'UTR	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1617										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		AAAAATGTCTGATGAGTGAGA	0.333													0	0	0	0.001984	0	6	46										C	56657229	G	C	56657229	3	2	54	1	0	0	0	0	1	0	0	0	2239	1299	45	1	167	1	C3orf63	3	56657229	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2813079	56657229	141365201	242	15020										
CADM2	253559	broad.mit.edu	37	chr3	85961684	85961684	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggtagccatgcaggtgctaGaaatacactgtaagtaaaca	10	7	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:85961684G>C	uc003dqj.2	+	5	1290	c.664G>C	c.(664-666)GAA>CAA	p.E222Q	CADM2_uc003dqk.2_Missense_Mutation_p.E231Q|CADM2_uc003dql.2_Missense_Mutation_p.E224Q	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	222	Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GCAGGTGCTAGAAATACACTG	0.468													0	0	0	0.004482	0	7	60										C	85961684	G	C	85961684	3	2	54	1	0	0	0	0	1	0	0	0	2567	943	33	1	753	1	CADM2	3	85961684	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	29304455	85961684	112060746	243	15021										
OR5K4	403278	broad.mit.edu	37	chr3	98073347	98073347	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cattgctactgtcttgatctCttatctctgcatccttttga	5	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:98073347C>G	uc011bgv.1	+	1	650	c.650C>G	c.(649-651)TCT>TGT	p.S217C		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GTCTTGATCTCTTATCTCTGC	0.353													0	0	0	0.004672	0	3	22										G	98073347	C	G	98073347	3	3	54	1	0	0	0	0	1	0	0	0	11169	913	32	1	652	1	OR5K4	3	98073347	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	12111663	98073347	99949083	244	15022										
FAM55C	91775	broad.mit.edu	37	chr3	101520284	101520284	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccagtcccctttgtgaagaGcactgacccttcttccagct	7	16	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:101520284G>A	uc003dvn.2	+	5	936	c.299G>A	c.(298-300)AGC>AAC	p.S100N	FAM55C_uc010hpn.2_Missense_Mutation_p.S100N	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	100						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						TTTGTGAAGAGCACTGACCCT	0.557													0	0	0	0.001855	0	11	73										A	101520284	G	A	101520284	3	1	54	1	0	0	0	0	1	0	0	0	5586	971	34	2	305	2	FAM55C	3	101520284	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3446937	101520284	96502146	245	15023										
PHLDB2	90102	broad.mit.edu	37	chr3	111603754	111603754	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagcttgcctccaagaaactCtctgggcaattccaaacgaa	7	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:111603754C>G	uc010hqa.2	+	2	1241	c.830C>G	c.(829-831)TCT>TGT	p.S277C	PHLDB2_uc003dyc.2_Missense_Mutation_p.S304C|PHLDB2_uc003dyd.2_Missense_Mutation_p.S277C|PHLDB2_uc003dyg.2_Missense_Mutation_p.S277C|PHLDB2_uc003dyh.2_Missense_Mutation_p.S277C|PHLDB2_uc003dye.3_Missense_Mutation_p.S277C|PHLDB2_uc003dyf.3_Missense_Mutation_p.S277C	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	277						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CCAAGAAACTCTCTGGGCAAT	0.473													0	0	0	0.006214	0	8	21										G	111603754	C	G	111603754	3	3	54	1	0	0	0	0	1	0	0	0	11852	913	32	1	917	1	PHLDB2	3	111603754	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10083470	111603754	86418676	246	15024										
WDR52	55779	broad.mit.edu	37	chr3	113128161	113128161	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacataagcatatcccttctCagtcccatctggaaggataa	6	12	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:113128161C>T	uc003eae.1	-	7	728	c.682G>A	c.(682-684)GAG>AAG	p.E228K		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	228	WD 1.									central_nervous_system(1)	1						TATCCCTTCTCAGTCCCATCT	0.398													0	0	0	0.001984	0	5	33										T	113128161	C	T	113128161	3	4	54	1	0	0	0	0	1	0	0	0	17301	835	29	1	5013	1	WDR52	3	113128161	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1524407	113128161	84894269	247	15025										
LSAMP	4045	broad.mit.edu	37	chr3	115560818	115560818	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccctccgtgctcttaatctCaaggccattggcactattta	7	13	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:115560818C>G	uc003ebt.2	-	6	1293	c.793G>C	c.(793-795)GAG>CAG	p.E265Q	LSAMP_uc011bis.1_Missense_Mutation_p.E265Q	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	265	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CTCTTAATCTCAAGGCCATTG	0.483													0	0	0	0.00308	0	6	51										G	115560818	C	G	115560818	3	3	54	1	0	0	0	0	1	0	0	0	9048	835	29	1	231	1	LSAMP	3	115560818	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2432657	115560818	82461612	248	15026										
FSTL1	11167	broad.mit.edu	37	chr3	120128498	120128498	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagctcatcacggttggactGatagcaaacaactgcaggaa	11	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:120128498G>A	uc003eds.2	-	6	518	c.343C>T	c.(343-345)CAG>TAG	p.Q115*	FSTL1_uc011bjh.1_Nonsense_Mutation_p.Q80*	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	115					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		CGGTTGGACTGATAGCAAACA	0.542													0	0	0	0.006122	0	13	52										A	120128498	G	A	120128498	4	1	54	1	0	0	0	0	0	1	0	0	6077	1299	45	1	607	1	FSTL1	3	120128498	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4567680	120128498	77893932	249	15027										
HSPBAP1	79663	broad.mit.edu	37	chr3	122459618	122459618	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgtgctctccatctgttctCagtgcttggatttctactac	7	11	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:122459618C>T	uc003efu.1	-	8	1164	c.1041G>A	c.(1039-1041)CTG>CTA	p.L347L	HSPBAP1_uc003eft.1_Silent_p.L58L	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	347						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		CATCTGTTCTCAGTGCTTGGA	0.448													0	0	0	0.00278	0	21	152										T	122459618	C	T	122459618	2	4	54	1	0	0	0	0	0	0	0	1	7425	813	29	1		1	HSPBAP1	3	122459618	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2331120	122459618	75562812	250	15028										
SEMA5B	54437	broad.mit.edu	37	chr3	122667551	122667551	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccgggaggcagacaggggaGaagacctgcaacgtaaacac	14	10	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:122667551G>A	uc003efz.1	-	3	434	c.130C>T	c.(130-132)CTC>TTC	p.L44F	SEMA5B_uc011bju.1_5'UTR|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.L44F|SEMA5B_uc010hro.1_5'UTR|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	44	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		AGACAGGGGAGAAGACCTGCA	0.592													0	0	0	0.001168	0	5	46										A	122667551	G	A	122667551	3	1	54	1	0	0	0	0	1	0	0	0	14038	942	33	1	3409	1	SEMA5B	3	122667551	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	207933	122667551	75354879	251	15029										
ADCY5	111	broad.mit.edu	37	chr3	123014973	123014973	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggcgggcagtggactccacCtgctgggcgtgcaggtacag	17	11	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:123014973C>T	uc003egh.1	-	17	3021	c.3021G>A	c.(3019-3021)CAG>CAA	p.Q1007Q	ADCY5_uc003egg.1_Silent_p.Q665Q	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1007	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		TGGACTCCACCTGCTGGGCGT	0.632													0	0	0	0.00278	0	19	126										T	123014973	C	T	123014973	2	4	54	1	0	0	0	0	0	0	0	1	297	680	24	2		2	ADCY5	3	123014973	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	347422	123014973	75007457	252	15030										
KALRN	8997	broad.mit.edu	37	chr3	124181431	124181431	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccctgggatcctcaataaaGagcatatcatctttggcaac	7	12	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:124181431G>C	uc003ehg.2	+	25	4103	c.3976G>C	c.(3976-3978)GAG>CAG	p.E1326Q	KALRN_uc010hrv.1_Missense_Mutation_p.E1317Q|KALRN_uc003ehf.1_Missense_Mutation_p.E1326Q|KALRN_uc011bjy.1_Missense_Mutation_p.E1317Q|KALRN_uc003ehh.1_Missense_Mutation_p.E672Q	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1326	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CCTCAATAAAGAGCATATCAT	0.473													0	0	0	0.004482	0	5	42										C	124181431	G	C	124181431	3	2	54	1	0	0	0	0	1	0	0	0	7975	943	33	1	4074	1	KALRN	3	124181431	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1166458	124181431	73840999	253	15031										
KALRN	8997	broad.mit.edu	37	chr3	124211637	124211637	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcaagaacattcgagaagtGattcaagaaaggatcattca	8	6	4	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:124211637G>A	uc003ehg.2	+	32	4861	c.4734G>A	c.(4732-4734)GTG>GTA	p.V1578V	KALRN_uc010hrv.1_Silent_p.V1569V|KALRN_uc003ehf.1_Silent_p.V1578V|KALRN_uc011bjy.1_Silent_p.V1569V	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1578	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TTCGAGAAGTGATTCAAGAAA	0.468													0	0	0	0.004482	0	7	87										A	124211637	G	A	124211637	2	1	54	1	0	0	0	0	0	0	0	1	7975	1277	45	1		1	KALRN	3	124211637	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	30206	124211637	73810793	254	15032										
UMPS	7372	broad.mit.edu	37	chr3	124456651	124456651	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtccaaaatgctggagattCtcgagcagcagaaaaaagtt	10	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:124456651C>T	uc003ehl.3	+	3	653	c.547C>T	c.(547-549)CTC>TTC	p.L183F	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Intron|UMPS_uc011bkb.1_Missense_Mutation_p.L91F|UMPS_uc011bkc.1_Missense_Mutation_p.L5F|UMPS_uc003ehn.3_Missense_Mutation_p.L5F|UMPS_uc011bkd.1_Missense_Mutation_p.L5F	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	183	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		GCTGGAGATTCTCGAGCAGCA	0.498													0	0	0	0.006214	0	7	33										T	124456651	C	T	124456651	3	4	54	1	0	0	0	0	1	0	0	0	16978	913	32	1	557	1	UMPS	3	124456651	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	245014	124456651	73565779	255	15033			3	60		3	3	214	C		2.872668e-05
UMPS	7372	broad.mit.edu	37	chr3	124456779	124456779	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaggaagcacccaaagaactCagcttcggtgcacgtgcaga	11	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:124456779C>G	uc003ehl.3	+	3	781	c.675C>G	c.(673-675)CTC>CTG	p.L225L	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Silent_p.L47L|UMPS_uc011bkb.1_Silent_p.L133L|UMPS_uc011bkc.1_Silent_p.L47L|UMPS_uc003ehn.3_Silent_p.L47L|UMPS_uc011bkd.1_Silent_p.L47L	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	225	OMPdecase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		CCAAAGAACTCAGCTTCGGTG	0.483													0	0	0	0.000602	0	4	32										G	124456779	C	G	124456779	2	3	54	1	0	0	0	0	0	0	0	1	16978	813	29	1		1	UMPS	3	124456779	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	128	124456779	73565651	256	15034			3	60		3	3	214	C		2.872668e-05
UMPS	7372	broad.mit.edu	37	chr3	124456864	124456864	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcaaaagaaggagaccaatCtgtgtctatctgctgatgtt	10	7	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:124456864C>T	uc003ehl.3	+	3	866	c.760C>T	c.(760-762)CTG>TTG	p.L254L	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Silent_p.L76L|UMPS_uc011bkb.1_Silent_p.L162L|UMPS_uc011bkc.1_Silent_p.L76L|UMPS_uc003ehn.3_Silent_p.L76L|UMPS_uc011bkd.1_Silent_p.L76L	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	254	OMPdecase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		GGAGACCAATCTGTGTCTATC	0.488													0	0	0	0.001368	0	9	74										T	124456864	C	T	124456864	2	4	54	1	0	0	0	0	0	0	0	1	16978	912	32	1		1	UMPS	3	124456864	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	85	124456864	73565566	257	15035			3	60		3	3	214	C		2.872668e-05
CCDC37	348807	broad.mit.edu	37	chr3	126135240	126135240	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggctaagcacaccagcctgCggcggcagctgcagctggag	15	14	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:126135240C>T	uc003eiu.1	+	5	406	c.307C>T	c.(307-309)CGG>TGG	p.R103W	CCDC37_uc010hsg.1_Missense_Mutation_p.R103W	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	103	Potential.									ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		CACCAGCCTGCGGCGGCAGCT	0.662													0	0	0	0.006214	0	7	68										T	126135240	C	T	126135240	3	4	54	1	0	0	0	0	1	0	0	0	2809	759	27	2	321	2	CCDC37	3	126135240	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1678376	126135240	71887190	258	15036										
ZXDC	79364	broad.mit.edu	37	chr3	126193835	126193835	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttgtaagggcgctcgggctCgaagtggctgcgctggtggg	19	9	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:126193835C>G	uc003eiv.2	-	1	928	c.874G>C	c.(874-876)GAG>CAG	p.E292Q	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.E292Q	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	292					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		CGCTCGGGCTCGAAGTGGCTG	0.687													0	0	0	0.004672	0	2	11										G	126193835	C	G	126193835	3	3	54	1	0	0	0	0	1	0	0	0	18249	893	31	1	1748	1	ZXDC	3	126193835	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	58595	126193835	71828595	259	15037										
COPG	22820	broad.mit.edu	37	chr3	128991687	128991687	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcatgatgaagttcactgtCaaggactgtgatcccaccac	9	11	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:128991687C>G	uc003els.2	+	21	2296	c.2196C>G	c.(2194-2196)GTC>GTG	p.V732V	COPG_uc010htb.2_Silent_p.V638V	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	732	Interaction with ZNF289/ARFGAP2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						AGTTCACTGTCAAGGACTGTG	0.547													0	0	0	0.00245	0	11	67										G	128991687	C	G	128991687	2	3	54	1	0	0	0	0	0	0	0	1	3731	813	29	1		1	COPG	3	128991687	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2797852	128991687	69030743	260	15038										
DNAJC13	23317	broad.mit.edu	37	chr3	132215491	132215491	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaacacagagcatcctcttCaaccgtcataaagaaggtaa	6	10	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:132215491C>T	uc003eor.2	+	36	4205	c.4140C>T	c.(4138-4140)TTC>TTT	p.F1380F		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1380							heat shock protein binding			ovary(1)|breast(1)	2						GCATCCTCTTCAACCGTCATA	0.338													0	0	0	0.001168	0	5	27										T	132215491	C	T	132215491	2	4	54	1	0	0	0	0	0	0	0	1	4632	825	29	1		1	DNAJC13	3	132215491	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3223804	132215491	65806939	261	15039										
EPHB1	2047	broad.mit.edu	37	chr3	134873013	134873013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccccctccaccgttcccatCatgcaccaagtcagtgccac	6	20	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:134873013C>G	uc003eqt.2	+	6	1537	c.1317C>G	c.(1315-1317)ATC>ATG	p.I439M	EPHB1_uc003equ.2_Translation_Start_Site	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	439	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CCGTTCCCATCATGCACCAAG	0.537													0	0	0	0.00874	0	34	278										G	134873013	C	G	134873013	3	3	54	1	0	0	0	0	1	0	0	0	5174	816	29	1	1339	1	EPHB1	3	134873013	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2657522	134873013	63149417	262	15040										
TMEM22	80723	broad.mit.edu	37	chr3	136574265	136574265	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggagaaacctggagttatctCattgctatatgtgtctgttc	10	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:136574265C>G	uc003erf.3	+	2	1177	c.963C>G	c.(961-963)CTC>CTG	p.L321L	TMEM22_uc003erg.3_Silent_p.L321L|TMEM22_uc010hub.2_Silent_p.L321L	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	321	DUF6 2.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						GGAGTTATCTCATTGCTATAT	0.388													0	0	0	0.003954	0	22	208										G	136574265	C	G	136574265	2	3	54	1	0	0	0	0	0	0	0	1	16140	813	29	1		1	TMEM22	3	136574265	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1701252	136574265	61448165	263	15041										
DZIP1L	199221	broad.mit.edu	37	chr3	137790534	137790534	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acagcgccattctcctgtctCtccttcgctctgctggtgac	8	16	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:137790534C>T	uc003erq.2	-	12	1929	c.1566G>A	c.(1564-1566)GAG>GAA	p.E522E	DZIP1L_uc003err.1_Silent_p.E522E	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	522						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						TCTCCTGTCTCTCCTTCGCTC	0.582													0	0	0	0.003163	0	12	96										T	137790534	C	T	137790534	2	4	54	1	0	0	0	0	0	0	0	1	4864	912	32	1		1	DZIP1L	3	137790534	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1216269	137790534	60231896	264	15042										
PRR23A	729627	broad.mit.edu	37	chr3	138724388	138724388	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcgcgtggggacctggactCcccacgcgcggagagggagg	19	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:138724388C>T	uc011bms.1	-	1	723	c.723G>A	c.(721-723)GGG>GGA	p.G241G		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	241	Pro-rich.										0						GACCTGGACTCCCCACGCGCG	0.652													0	0	0	0.004672	0	2	1										T	138724388	C	T	138724388	2	4	54	1	0	0	0	0	0	0	0	1	12594	842	30	1		1	PRR23A	3	138724388	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	933854	138724388	59298042	265	15043										
HLTF	6596	broad.mit.edu	37	chr3	148773120	148773120	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttaacacagaaagcggacaGatgatcagtgttgttcttgg	11	7	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:148773120G>C	uc003ewq.1	-	14	1661	c.1443C>G	c.(1441-1443)ATC>ATG	p.I481M	HLTF_uc003ewr.1_Missense_Mutation_p.I481M|HLTF_uc003ews.1_Missense_Mutation_p.I480M|HLTF_uc010hve.1_Missense_Mutation_p.I480M	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	481	Helicase ATP-binding.				chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AAAGCGGACAGATGATCAGTG	0.363													0	0	0	0.00245	0	10	62										C	148773120	G	C	148773120	3	2	54	1	0	0	0	0	1	0	0	0	7215	932	33	1	1634	1	HLTF	3	148773120	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10048732	148773120	49249310	266	15044										
CLRN1	7401	broad.mit.edu	37	chr3	150659542	150659542	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggattgctttgagcaaatctGgaaaaactgaagataagaca	10	5	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:150659542G>A	uc003eyk.1	-	2	551	c.260C>T	c.(259-261)CCA>CTA	p.P87L	CLRN1OS_uc011bny.1_Intron|CLRN1_uc003eyj.2_Missense_Mutation_p.P11L|CLRN1_uc010hvj.1_RNA	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	87					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GAGCAAATCTGGAAAAACTGA	0.368													0	0	0	0.009096	0	3	21										A	150659542	G	A	150659542	3	1	54	1	0	0	0	0	1	0	0	0	3557	1348	47	2	471	2	CLRN1	3	150659542	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1886422	150659542	47362888	267	15045										
MED12L	116931	broad.mit.edu	37	chr3	150903167	150903167	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgttatgtgaatgggccgtGagctgcaaacggtctggcaa	14	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:150903167G>T	uc003eyp.2	+	11	1583	c.1545G>T	c.(1543-1545)GTG>GTT	p.V515V	MED12L_uc011bnz.1_Silent_p.V375V|MED12L_uc003eyn.2_Silent_p.V515V|MED12L_uc003eyo.2_Silent_p.V515V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	515					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AATGGGCCGTGAGCTGCAAAC	0.517													1	0	2.27111e-07	0.001368	2.37751e-07	10	96										T	150903167	G	T	150903167	2	4	54	1	0	0	0	0	0	0	0	1	9429	1277	45	3		3	MED12L	3	150903167	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	243625	150903167	47119263	268	15046										
IGSF10	285313	broad.mit.edu	37	chr3	151155890	151155890	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acagctgtgtctccagctttGattctcttgttggttttgtt	9	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:151155890G>A	uc011bod.1	-	6	6459	c.6459C>T	c.(6457-6459)ATC>ATT	p.I2153I	IGSF10_uc011bob.1_Silent_p.I180I|IGSF10_uc011boc.1_Silent_p.I132I	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2153	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTCCAGCTTTGATTCTCTTGT	0.453													0	0	0	0.010729	0	9	42										A	151155890	G	A	151155890	2	1	54	1	0	0	0	0	0	0	0	1	7597	1280	45	1		1	IGSF10	3	151155890	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	252723	151155890	46866540	269	15047										
IGSF10	285313	broad.mit.edu	37	chr3	151166756	151166756	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgcaatgggtgatgtccttGagggcttttgaatactgcag	13	6	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:151166756G>C	uc011bod.1	-	4	1013	c.1013C>G	c.(1012-1014)TCA>TGA	p.S338*		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	338					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGATGTCCTTGAGGGCTTTTG	0.413													0	0	0	0.001855	0	11	76										C	151166756	G	C	151166756	4	2	54	1	0	0	0	0	0	1	0	0	7597	1294	45	1	6918	1	IGSF10	3	151166756	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10866	151166756	46855674	270	15048										
C3orf70	285382	broad.mit.edu	37	chr3	184870595	184870595	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaccccgctccgacgccggcGaggccgccgcactcatttcc	10	20	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:184870595G>A	uc003fpd.2	-	1	208	c.17C>T	c.(16-18)TCG>TTG	p.S6L		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	6											0						CGACGCCGGCGAGGCCGCCGC	0.716													0	0	0	0.004482	0	6	35										A	184870595	G	A	184870595	3	1	54	1	0	0	0	0	1	0	0	0	2242	1059	37	1	743	1	C3orf70	3	184870595	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	33703839	184870595	13151835	271	15049										
LPP	4026	broad.mit.edu	37	chr3	188327106	188327106	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acccatccctgtggctccaaTcggaacactcaaaccccagc	6	18	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:188327106T>C	uc003frs.1	+	6	833	c.587T>C	c.(586-588)ATC>ACC	p.I196T	LPP_uc011bsg.1_Missense_Mutation_p.I196T|LPP_uc011bsi.1_Missense_Mutation_p.I196T|LPP_uc003frt.2_Missense_Mutation_p.I196T|LPP_uc011bsj.1_Missense_Mutation_p.I33T	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	196	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GTGGCTCCAATCGGAACACTC	0.562			T	HMGA2|MLL|C12orf9	lipoma|leukemia								0	0	0	0.008361	0	28	132										C	188327106	T	C	188327106	3	2	54	1	0	0	0	0	1	0	0	0	8923	1435	50	5	601	5	LPP	3	188327106	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	3456511	188327106	9695324	272	15050										
CCDC50	152137	broad.mit.edu	37	chr3	191100573	191100573	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaaattccaagtcaaaagaGagtgatgaacctcaccattc	7	10	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:191100573G>A	uc003fsw.2	+	9	1343	c.753G>A	c.(751-753)GAG>GAA	p.E251E	CCDC50_uc003fsv.2_Silent_p.E427E	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	251						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		AGTCAAAAGAGAGTGATGAAC	0.373													0	0	0	0.001168	0	3	30										A	191100573	G	A	191100573	2	1	54	1	0	0	0	0	0	0	0	1	2820	933	33	1		1	CCDC50	3	191100573	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2773467	191100573	6921857	273	15051										
PYDC2	152138	broad.mit.edu	37	chr3	191178959	191178959	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacataggacaagatggcatCttctgcagagctggacttca	10	10	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:191178959C>T	uc011bso.1	+	1	8	c.8C>T	c.(7-9)TCT>TTT	p.S3F		NM_001083308	NP_001076777	Q56P42	PYDC2_HUMAN	pyrin domain containing 2	3	DAPIN.					cytoplasm|nucleus					0						AAGATGGCATCTTCTGCAGAG	0.428													0	0	0	0.001855	0	8	63										T	191178959	C	T	191178959	3	4	54	1	0	0	0	0	1	0	0	0	12859	913	32	1	10	1	PYDC2	3	191178959	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	78386	191178959	6843471	274	15052										
ATP13A4	84239	broad.mit.edu	37	chr3	193130105	193130105	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attactttccattttttctgGagcagttggagacatggtta	9	6	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:193130105G>A	uc003ftd.2	-	27	3178	c.3070C>T	c.(3070-3072)CCA>TCA	p.P1024S	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1024	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		ATTTTTTCTGGAGCAGTTGGA	0.408													0	0	0	0.00333	0	18	139										A	193130105	G	A	193130105	3	1	54	1	0	0	0	0	1	0	0	0	1126	1174	41	1	536	1	ATP13A4	3	193130105	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1951146	193130105	4892325	275	15053										
HES1	3280	broad.mit.edu	37	chr3	193855682	193855682	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgccttgcaggcgccgccacCgcccccaccgggacccggcg	13	22	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:193855682C>T	uc003ftq.1	+	4	739	c.503C>T	c.(502-504)CCG>CTG	p.P168L		NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	168	Pro-rich.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		GCGCCGCCACCGCCCCCACCG	0.627													0	0	0	0.001855	0	7	106										T	193855682	C	T	193855682	3	4	54	1	0	0	0	0	1	0	0	0	7065	652	23	2	517	2	HES1	3	193855682	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	725577	193855682	4166748	276	15054										
ATP13A3	79572	broad.mit.edu	37	chr3	194146180	194146180	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtggtattttcataattttgTatattatgttcatcaagttc	6	4	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:194146180T>C	uc003fty.3	-	29	3606	c.3204A>G	c.(3202-3204)ATA>ATG	p.I1068M	ATP13A3_uc003ftx.3_Translation_Start_Site	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1068					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CATAATTTTGTATATTATGTT	0.358													0	0	0	0.00308	0	6	35										C	194146180	T	C	194146180	3	2	54	1	0	0	0	0	1	0	0	0	1125	1628	57	5	492	5	ATP13A3	3	194146180	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	290498	194146180	3876250	277	15055										
ACAP2	23527	broad.mit.edu	37	chr3	195053852	195053852	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcatacataaatgacaacaTctaatagggaaaaaaagatg	8	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr3:195053852T>A	uc003fun.3	-	8	815	c.574A>T	c.(574-576)ATG>TTG	p.M192L		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	192	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AATGACAACATCTAATAGGGA	0.279													0	0	0	0.001855	0	12	57										A	195053852	T	A	195053852	3	1	54	1	0	0	0	0	1	0	0	0	119	1449	50	5	1826	5	ACAP2	3	195053852	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	907672	195053852	2968578	278	15056										
PIGG	54872	broad.mit.edu	37	chr4	499636	499636	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaatagtcttttatggagatGaaacctgggttaaattattc	9	4	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:499636G>A	uc003gak.3	+	3	626	c.490G>A	c.(490-492)GAA>AAA	p.E164K	PIGG_uc003gaj.3_Missense_Mutation_p.E164K|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Intron|PIGG_uc003gal.3_Missense_Mutation_p.E75K|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.E42K|PIGG_uc003gam.2_Missense_Mutation_p.E75K|PIGG_uc003gan.2_Missense_Mutation_p.E75K	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	164	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TTATGGAGATGAAACCTGGGT	0.383													0	0	0	0.00308	0	7	54										A	499636	G	A	499636	3	1	54	1	0	0	0	0	1	0	0	0	11888	1291	45	1	500	1	PIGG	4	499636	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		499636	190654640	279	15057										
KIAA1530	57654	broad.mit.edu	37	chr4	1343568	1343568	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgaccacccgggccgtggaaGggtggaatgagaagtttggg	18	8	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:1343568G>A	uc003gde.3	+	3	802	c.355G>A	c.(355-357)GGG>AGG	p.G119R		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	119											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GGCCGTGGAAGGGTGGAATGA	0.612													0	0	0	0.00308	0	5	31										A	1343568	G	A	1343568	3	1	54	1	0	0	0	0	1	0	0	0	8241	1000	35	2	361	2	KIAA1530	4	1343568	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	843932	1343568	189810708	280	15058										
WHSC1	7468	broad.mit.edu	37	chr4	1940246	1940246	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atggaggcagcctcctcgctCaagagccaggcaggtaatgt	13	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:1940246C>G	uc003gdz.3	+	8	1919	c.1743C>G	c.(1741-1743)CTC>CTG	p.L581L	WHSC1_uc003geb.3_Silent_p.L581L|WHSC1_uc003gec.3_Silent_p.L581L|WHSC1_uc003ged.3_Silent_p.L581L|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_5'Flank|WHSC1_uc003gdy.1_Silent_p.L581L|WHSC1_uc010icd.1_Silent_p.L581L|WHSC1_uc003gea.1_Silent_p.L581L|WHSC1_uc010ice.1_Silent_p.L581L|WHSC1_uc003geh.1_Silent_p.L581L	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	581					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCTCCTCGCTCAAGAGCCAGG	0.498			T	IGH@	MM								0	0	0	0.001855	0	10	86										G	1940246	C	G	1940246	2	3	54	1	0	0	0	0	0	0	0	1	17359	813	29	1		1	WHSC1	4	1940246	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	596678	1940246	189214030	281	15059										
FAM193A	8603	broad.mit.edu	37	chr4	2673965	2673965	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccatcagttcttgagcccaGagaagcccacacaccctgca	8	16	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:2673965G>C	uc010icl.2	+	11	1675	c.1324G>C	c.(1324-1326)GAG>CAG	p.E442Q	FAM193A_uc010ick.2_Missense_Mutation_p.E642Q|FAM193A_uc003gfd.2_Missense_Mutation_p.E442Q|FAM193A_uc011bvm.1_Missense_Mutation_p.E464Q|FAM193A_uc011bvn.1_Missense_Mutation_p.E442Q|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.E296Q	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	442										ovary(3)	3						CTTGAGCCCAGAGAAGCCCAC	0.552													0	0	0	0.001368	0	11	85										C	2673965	G	C	2673965	3	2	54	1	0	0	0	0	1	0	0	0	5524	943	33	1	1358	1	FAM193A	4	2673965	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	733719	2673965	188480311	282	15060										
LRPAP1	4043	broad.mit.edu	37	chr4	3516565	3516565	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcgccgtcgcccacgctctCtgcgtgcctcagcttctcgt	9	19	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:3516565C>G	uc003ghi.2	-	7	1010	c.925G>C	c.(925-927)GAG>CAG	p.E309Q		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	309	LDL receptor binding (Potential).|Potential.				negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		CCCACGCTCTCTGCGTGCCTC	0.632													0	0	0	0.010504	0	19	148										G	3516565	C	G	3516565	3	3	54	1	0	0	0	0	1	0	0	0	8964	922	32	1	156	1	LRPAP1	4	3516565	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	842600	3516565	187637711	283	15061										
CRMP1	1400	broad.mit.edu	37	chr4	5827255	5827255	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttggactggtggaggtttctGatgggtgggggctggtgttt	20	3	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:5827255G>A	uc003gip.2	-	14	1694	c.1593C>T	c.(1591-1593)ATC>ATT	p.I531I	EVC_uc003gim.1_Intron|CRMP1_uc003gin.1_Silent_p.I443I|CRMP1_uc003giq.2_Silent_p.I531I|CRMP1_uc003gir.2_Silent_p.I526I|CRMP1_uc003gis.2_Silent_p.I645I	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	531					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		GGAGGTTTCTGATGGGTGGGG	0.547													0	0	0	0.004007	0	13	80										A	5827255	G	A	5827255	2	1	54	1	0	0	0	0	0	0	0	1	3890	1280	45	1		1	CRMP1	4	5827255	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2310690	5827255	185327021	284	15062										
GRPEL1	80273	broad.mit.edu	37	chr4	7062677	7062677	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctaactagggccactgtgCctggctccttcccctcaacc	8	17	1	0	rs144832422	byFrequency	TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:7062677C>T	uc003gjy.1	-	4	607	c.566G>A	c.(565-567)GGC>GAC	p.G189D	GRPEL1_uc003gjz.1_3'UTR	NM_025196	NP_079472	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial precursor	189					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding				0						GGCCACTGTGCCTGGCTCCTT	0.567													0	0	0	0.011902	0	43	255										T	7062677	C	T	7062677	3	4	54	1	0	0	0	0	1	0	0	0	6806	739	26	2	91	2	GRPEL1	4	7062677	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1235422	7062677	184091599	285	15063										
ANAPC4	29945	broad.mit.edu	37	chr4	25395483	25395483	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggaagaaatactaatgcaGatggattctcgtctcaccaa	9	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:25395483G>C	uc003gro.2	+	11	975	c.846G>C	c.(844-846)CAG>CAC	p.Q282H	ANAPC4_uc003grp.2_Missense_Mutation_p.Q167H|ANAPC4_uc010iet.1_Intron|ANAPC4_uc010ieu.1_Missense_Mutation_p.Q91H	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	282					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				TACTAATGCAGATGGATTCTC	0.333													0	0	0	0.001984	0	4	43										C	25395483	G	C	25395483	3	2	54	1	0	0	0	0	1	0	0	0	604	933	33	1	884	1	ANAPC4	4	25395483	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	18332806	25395483	165758793	286	15064										
RBPJ	3516	broad.mit.edu	37	chr4	26432520	26432520	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaatccttcgagccaattCaagccaggtgccccctaacg	8	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:26432520C>T	uc003grx.1	+	12	1630	c.1394C>T	c.(1393-1395)TCA>TTA	p.S465L	RBPJ_uc003gry.1_Missense_Mutation_p.S450L|RBPJ_uc003grz.1_Missense_Mutation_p.S465L|RBPJ_uc003gsa.1_Missense_Mutation_p.S451L|RBPJ_uc003gsb.1_Missense_Mutation_p.S452L|RBPJ_uc003gsc.1_3'UTR|uc003gsd.2_5'Flank	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	465					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				CGAGCCAATTCAAGCCAGGTG	0.507													0	0	0	0.010729	0	10	69										T	26432520	C	T	26432520	3	4	54	1	0	0	0	0	1	0	0	0	13161	838	29	1	1499	1	RBPJ	4	26432520	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1037037	26432520	164721756	287	15065										
FAM114A1	92689	broad.mit.edu	37	chr4	38910248	38910248	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actggaggccttgatgcgttGgaattcatcggcaagaaaac	12	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:38910248G>A	uc003gtn.2	+	7	869	c.693G>A	c.(691-693)TTG>TTA	p.L231L	FAM114A1_uc011byh.1_Silent_p.L24L	NM_138389	NP_612398	Q8IWE2	NXP20_HUMAN	hypothetical protein LOC92689	231						cytoplasm				ovary(1)	1						TTGATGCGTTGGAATTCATCG	0.468													0	0	0	0.001984	0	7	64										A	38910248	G	A	38910248	2	1	54	1	0	0	0	0	0	0	0	1	5403	1339	47	2		2	FAM114A1	4	38910248	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	12477728	38910248	152244028	288	15066										
KLHL5	51088	broad.mit.edu	37	chr4	39116803	39116803	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatcccaaaacagacatgtgGactgcagtagcatccatgag	10	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:39116803G>A	uc003gts.2	+	10	2139	c.2064G>A	c.(2062-2064)TGG>TGA	p.W688*	KLHL5_uc003gtp.2_Nonsense_Mutation_p.W642*|KLHL5_uc003gtq.2_Nonsense_Mutation_p.W501*|KLHL5_uc003gtr.1_Nonsense_Mutation_p.W688*|KLHL5_uc003gtt.2_Nonsense_Mutation_p.W627*	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1	688	Kelch 5.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1						CAGACATGTGGACTGCAGTAG	0.398													0	0	0	0.008291	0	7	82										A	39116803	G	A	39116803	4	1	54	1	0	0	0	0	0	1	0	0	8392	1183	41	1	2102	1	KLHL5	4	39116803	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	206555	39116803	152037473	289	15067										
KLB	152831	broad.mit.edu	37	chr4	39448748	39448748	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgacgggggctttccagctCggccctgccgcgcctcaccg	13	19	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:39448748C>G	uc003gua.2	+	4	2499	c.2402C>G	c.(2401-2403)TCG>TGG	p.S801W	KLB_uc011byj.1_Missense_Mutation_p.S792W	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	801	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						CTTTCCAGCTCGGCCCTGCCG	0.647													0	0	0	0.00499	0	16	74										G	39448748	C	G	39448748	3	3	54	1	0	0	0	0	1	0	0	0	8332	893	31	1	2416	1	KLB	4	39448748	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	331945	39448748	151705528	290	15068										
RHOH	399	broad.mit.edu	37	chr4	40245012	40245012	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagcaggctgggaagatgctGagttccatcaagtgcgtgtt	14	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:40245012G>C	uc003guz.2	+	3	730	c.6G>C	c.(4-6)CTG>CTC	p.L2L		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	2					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						GGAAGATGCTGAGTTCCATCA	0.582													0	0	0	0.007413	0	16	88										C	40245012	G	C	40245012	2	2	54	1	0	0	0	0	0	0	0	1	13340	1277	45	1		1	RHOH	4	40245012	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	796264	40245012	150909264	291	15069										
KDR	3791	broad.mit.edu	37	chr4	55968637	55968637	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttccccaatacttgtcgtctGattctccaggtttcctgtga	7	12	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:55968637G>A	uc003has.2	-	14	2328	c.2026C>T	c.(2026-2028)CAG>TAG	p.Q676*	KDR_uc003hat.1_Nonsense_Mutation_p.Q676*	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	676	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CTTGTCGTCTGATTCTCCAGG	0.438			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.000602	0	4	15										A	55968637	G	A	55968637	4	1	54	1	0	0	0	0	0	1	0	0	8139	1299	45	1	2112	1	KDR	4	55968637	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	15723625	55968637	135185639	292	15070										
KIAA1211	57482	broad.mit.edu	37	chr4	57179512	57179512	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctgttaagccaaaaaaacaGagggtgtcaaagaagcacag	11	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:57179512G>A	uc003hbk.2	+	7	895	c.504G>A	c.(502-504)CAG>CAA	p.Q168Q	KIAA1211_uc010iha.2_Silent_p.Q161Q|KIAA1211_uc011bzz.1_Silent_p.Q78Q|KIAA1211_uc003hbm.1_Silent_p.Q54Q	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	168										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CAAAAAAACAGAGGGTGTCAA	0.567													0	0	0	0.001855	0	12	102										A	57179512	G	A	57179512	2	1	54	1	0	0	0	0	0	0	0	1	8215	933	33	1		1	KIAA1211	4	57179512	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1210875	57179512	133974764	293	15071										
SPINK2	6691	broad.mit.edu	37	chr4	57677932	57677932	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggttaaagtgtctgggacatCctggtaatctatactgagag	12	6	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:57677932C>T	uc003hcg.1	-	3	193	c.128G>A	c.(127-129)GGA>GAA	p.G43E		NM_021114	NP_066937	P20155	ISK2_HUMAN	serine protease inhibitor, Kazal type 2	43	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity				0	Glioma(25;0.08)|all_neural(26;0.181)					TCTGGGACATCCTGGTAATCT	0.393													0	0	0	0.00278	0	19	134										T	57677932	C	T	57677932	3	4	54	1	0	0	0	0	1	0	0	0	15059	855	30	1	134	1	SPINK2	4	57677932	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	498420	57677932	133476344	294	15072										
C4orf14	84273	broad.mit.edu	37	chr4	57829640	57829640	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acatttatctttcctttcttCttcctcacgttgtacataag	3	11	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:57829640C>A	uc003hck.2	-	7	2148	c.2073G>T	c.(2071-2073)AAG>AAT	p.K691N		NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	691							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					TTCCTTTCTTCTTCCTCACGT	0.358													1	0	2.39556e-15	0.00278	2.57008e-15	21	88										A	57829640	C	A	57829640	3	1	54	1	0	0	0	0	1	0	0	0	2251	912	32	3	27	3	C4orf14	4	57829640	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	151708	57829640	133324636	295	15073										
ANKRD17	26057	broad.mit.edu	37	chr4	74019627	74019627	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctaaggtaagggcactctCtttaaattcattagaatgcg	9	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:74019627C>G	uc003hgp.2	-	6	1321	c.1204G>C	c.(1204-1206)GAG>CAG	p.E402Q	ANKRD17_uc003hgo.2_Missense_Mutation_p.E289Q|ANKRD17_uc003hgq.2_Missense_Mutation_p.E402Q|ANKRD17_uc003hgr.2_Missense_Mutation_p.E402Q|ANKRD17_uc011cbd.1_Missense_Mutation_p.E31Q	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	402	ANK 6.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGGGCACTCTCTTTAAATTCA	0.348													0	0	0	0.004482	0	6	57										G	74019627	C	G	74019627	3	3	54	1	0	0	0	0	1	0	0	0	646	922	32	1	6723	1	ANKRD17	4	74019627	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	16189987	74019627	117134649	296	15074										
PPEF2	5470	broad.mit.edu	37	chr4	76817437	76817437	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacgtacctctctctgcattCtggaaagcaaaatgatgttg	8	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:76817437C>T	uc003hix.2	-	2	399	c.42G>A	c.(40-42)CAG>CAA	p.Q14Q	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Silent_p.Q14Q	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	14					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTCTGCATTCTGGAAAGCAA	0.527											OREG0016229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	16	105										T	76817437	C	T	76817437	2	4	54	1	0	0	0	0	0	0	0	1	12308	912	32	1		1	PPEF2	4	76817437	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2797810	76817437	114336839	297	15075										
SDAD1	55153	broad.mit.edu	37	chr4	76882204	76882204	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaatttcttctgcagcatctGaggattcagtgttcggaaga	11	7	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:76882204G>A	uc003hje.3	-	16	1452	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*	SDAD1_uc003hjf.3_Nonsense_Mutation_p.Q348*|SDAD1_uc011cbr.1_Nonsense_Mutation_p.Q408*	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	445					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGCAGCATCTGAGGATTCAGT	0.363													0	0	0	0.007413	0	14	99										A	76882204	G	A	76882204	4	1	54	1	0	0	0	0	0	1	0	0	13950	1299	45	1	758	1	SDAD1	4	76882204	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	64767	76882204	114272072	298	15076										
PRKG2	5593	broad.mit.edu	37	chr4	82065388	82065388	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaacattcctccacttacttCgcatgtcttttttcatcatc	2	13	3	0	rs112801782	byFrequency	TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:82065388C>T	uc003hmh.2	-	9	1265	c.1251G>A	c.(1249-1251)GCG>GCA	p.A417A	PRKG2_uc011ccf.1_5'UTR|PRKG2_uc011ccg.1_5'UTR|PRKG2_uc011cch.1_Silent_p.A417A	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	417	cGMP 2.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						CCACTTACTTCGCATGTCTTT	0.428													0	0	0	0.004482	0	7	34										T	82065388	C	T	82065388	2	4	54	1	0	0	0	0	0	0	0	1	12523	871	31	1		1	PRKG2	4	82065388	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5183184	82065388	109088888	299	15077										
PTPN13	5783	broad.mit.edu	37	chr4	87730928	87730928	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttatacaatttcagaccagaGaggtgcgccatatttctcat	7	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:87730928G>C	uc003hpz.2	+	46	7570	c.7090G>C	c.(7090-7092)GAG>CAG	p.E2364Q	PTPN13_uc003hpy.2_Missense_Mutation_p.E2369Q|PTPN13_uc003hqa.2_Missense_Mutation_p.E2345Q|PTPN13_uc003hqb.2_Missense_Mutation_p.E2173Q	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2364	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAGACCAGAGAGGTGCGCCA	0.323													0	0	0	0.003163	0	11	70										C	87730928	G	C	87730928	3	2	54	1	0	0	0	0	1	0	0	0	12782	943	33	1	7283	1	PTPN13	4	87730928	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5665540	87730928	103423348	300	15078										
DSPP	1834	broad.mit.edu	37	chr4	88534227	88534227	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcatgatagtagcataggtCaaaattcagatagtaaagaa	8	4	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:88534227C>G	uc003hqu.2	+	4	1009	c.889C>G	c.(889-891)CAA>GAA	p.Q297E		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	297					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		TAGCATAGGTCAAAATTCAGA	0.428													0	0	0	0.00308	0	6	30										G	88534227	C	G	88534227	3	3	54	1	0	0	0	0	1	0	0	0	4782	827	29	1	899	1	DSPP	4	88534227	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	803299	88534227	102620049	301	15079										
HERC6	55008	broad.mit.edu	37	chr4	89334244	89334244	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacagataactacgtgtctcGaggatgatctgctcagagct	10	10	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:89334244G>A	uc011cdi.1	+	12	1567	c.1384G>A	c.(1384-1386)GAG>AAG	p.E462K	HERC6_uc011cdj.1_Missense_Mutation_p.E462K|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	462					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TACGTGTCTCGAGGATGATCT	0.433													0	0	0	0.00623	0	26	150										A	89334244	G	A	89334244	3	1	54	1	0	0	0	0	1	0	0	0	7062	1059	37	1	1227	1	HERC6	4	89334244	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	800017	89334244	101820032	302	15080										
SMARCAD1	56916	broad.mit.edu	37	chr4	95201922	95201922	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggatgcatcttgtctgaattGaaacagaaggtattaaaaaa	9	4	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:95201922G>A	uc003htc.3	+	20	2853	c.2598G>A	c.(2596-2598)TTG>TTA	p.L866L	SMARCAD1_uc003htb.3_Silent_p.L868L|SMARCAD1_uc003htd.3_Silent_p.L868L|SMARCAD1_uc010ila.2_Silent_p.L731L|SMARCAD1_uc011cdw.1_Silent_p.L436L	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	866	Helicase C-terminal.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TGTCTGAATTGAAACAGAAGG	0.323													0	0	0	0.001368	0	10	67										A	95201922	G	A	95201922	2	1	54	1	0	0	0	0	0	0	0	1	14772	1281	45	1		1	SMARCAD1	4	95201922	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5867678	95201922	95952354	303	15081										
ADH1A	124	broad.mit.edu	37	chr4	100200605	100200605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttcccagagtgaagcaggtCaaatccttcatttatttttt	6	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:100200605C>G	uc003hur.1	-	8	1152	c.1081G>C	c.(1081-1083)GAC>CAC	p.D361H	uc003hum.1_Intron|ADH1A_uc011ceg.1_Missense_Mutation_p.D361H	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	361					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	TGAAGCAGGTCAAATCCTTCA	0.338													0	0	0	0.001168	0	6	11										G	100200605	C	G	100200605	3	3	54	1	0	0	0	0	1	0	0	0	307	826	29	1	54	1	ADH1A	4	100200605	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4998683	100200605	90953671	304	15082										
MTTP	4547	broad.mit.edu	37	chr4	100512501	100512501	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggtctggatttacgacccCaaatcaggtatgatagatgt	11	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:100512501C>T	uc003hvc.3	+	6	867	c.611C>T	c.(610-612)CCA>CTA	p.P204L	MTTP_uc011cej.1_Missense_Mutation_p.P231L	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	204	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TTTACGACCCCAAATCAGGTA	0.328													0	0	0	0.009096	0	3	22										T	100512501	C	T	100512501	3	4	54	1	0	0	0	0	1	0	0	0	9964	594	21	2	629	2	MTTP	4	100512501	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	311896	100512501	90641775	305	15083										
BANK1	55024	broad.mit.edu	37	chr4	102981531	102981531	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagatgggaaaaagtggcctGgaaatgattcagcaggtaat	13	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:102981531G>C	uc003hvy.3	+	12	2407	c.2133G>C	c.(2131-2133)CTG>CTC	p.L711L	BANK1_uc003hvx.3_Silent_p.L696L|BANK1_uc010ill.2_Silent_p.L578L|BANK1_uc003hvz.3_Silent_p.L681L	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	711					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AAAGTGGCCTGGAAATGATTC	0.413													0	0	0	0.00308	0	6	39										C	102981531	G	C	102981531	2	2	54	1	0	0	0	0	0	0	0	1	1309	1335	47	4		4	BANK1	4	102981531	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2469030	102981531	88172745	306	15084										
RRH	10692	broad.mit.edu	37	chr4	110757312	110757312	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccataaactggaggaaaaatGataggtaagagacaagttta	10	4	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:110757312G>A	uc003hzv.2	+	4	581	c.547G>A	c.(547-549)GAT>AAT	p.D183N		NM_006583	NP_006574	O14718	OPSX_HUMAN	peropsin	183	Extracellular.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		GAGGAAAAATGATAGGTAAGA	0.398													0	0	0	0.001168	0	5	42										A	110757312	G	A	110757312	3	1	54	1	0	0	0	0	1	0	0	0	13680	1290	45	1	561	1	RRH	4	110757312	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7775781	110757312	80396964	307	15085										
ENPEP	2028	broad.mit.edu	37	chr4	111430911	111430911	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgaccctaaggaatcagcctCatcaaaccaacagagggtgg	10	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:111430911C>G	uc003iab.3	+	5	1484	c.1142C>G	c.(1141-1143)TCA>TGA	p.S381*		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	381	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GAATCAGCCTCATCAAACCAA	0.453													0	0	0	0.006214	0	7	70										G	111430911	C	G	111430911	4	3	54	1	0	0	0	0	0	1	0	0	5128	838	29	1	1160	1	ENPEP	4	111430911	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	673599	111430911	79723365	308	15086										
SYNPO2	171024	broad.mit.edu	37	chr4	119947939	119947939	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctcgcccctgtcaagactGaagttcccctagctgagaac	8	15	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:119947939G>A	uc003icm.3	+	3	611	c.415G>A	c.(415-417)GAA>AAA	p.E139K	SYNPO2_uc010ina.2_Missense_Mutation_p.E139K|SYNPO2_uc010inb.2_Missense_Mutation_p.E139K|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.E67K	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	139						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TGTCAAGACTGAAGTTCCCCT	0.542													0	0	0	0.006214	0	7	41										A	119947939	G	A	119947939	3	1	54	1	0	0	0	0	1	0	0	0	15454	1291	45	1	425	1	SYNPO2	4	119947939	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8517028	119947939	71206337	309	15087										
MAD2L1	4085	broad.mit.edu	37	chr4	120987847	120987847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggccacgatttcggcgctccCgcgcagggtgattccctgct	13	15	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:120987847C>T	uc003idl.2	-	1	167	c.43G>A	c.(43-45)GGG>AGG	p.G15R	MAD2L1_uc003idm.2_Missense_Mutation_p.G15R	NM_002358	NP_002349	Q13257	MD2L1_HUMAN	MAD2-like 1	15	HORMA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of apoptosis|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of mitotic cell cycle spindle assembly checkpoint	condensed chromosome kinetochore|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity				0						TCGGCGCTCCCGCGCAGGGTG	0.637													0	0	0	0.008291	0	8	63										T	120987847	C	T	120987847	3	4	54	1	0	0	0	0	1	0	0	0	9148	652	23	2	594	2	MAD2L1	4	120987847	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1039908	120987847	70166429	310	15088										
PLK4	10733	broad.mit.edu	37	chr4	128811324	128811324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttatcagaatcgtacattaaGaagcattacatctccgttgg	7	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:128811324G>C	uc003ifo.2	+	7	2008	c.1763G>C	c.(1762-1764)AGA>ACA	p.R588T	PLK4_uc011cgs.1_Missense_Mutation_p.R556T|PLK4_uc011cgt.1_Missense_Mutation_p.R547T	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	588					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						CGTACATTAAGAAGCATTACA	0.393													0	0	0	0.006214	0	8	40										C	128811324	G	C	128811324	3	2	54	1	0	0	0	0	1	0	0	0	12098	942	33	1	1789	1	PLK4	4	128811324	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7823477	128811324	62342952	311	15089										
MAML3	55534	broad.mit.edu	37	chr4	140646942	140646942	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctgcactgggtatggattCcgctgtggctggaggtgctg	17	8	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:140646942C>G	uc003ihz.1	-	6	3116	c.2364G>C	c.(2362-2364)CGG>CGC	p.R788R	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Silent_p.R256R	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	789	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					GGTATGGATTCCGCTGTGGCT	0.512													0	0	0	0.008871	0	15	115										G	140646942	C	G	140646942	2	3	54	1	0	0	0	0	0	0	0	1	9207	842	30	1		1	MAML3	4	140646942	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11835618	140646942	50507334	312	15090										
PET112L	5188	broad.mit.edu	37	chr4	152682052	152682052	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggacccagtcggagcccctCttcggtggcaagaaccaccg	12	15	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:152682052C>T	uc003iml.2	-	1	95	c.83G>A	c.(82-84)AGA>AAA	p.R28K	PET112L_uc003imm.3_Missense_Mutation_p.R28K	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	28						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGGAGCCCCTCTTCGGTGGCA	0.622													0	0	0	0.006214	0	8	69										T	152682052	C	T	152682052	3	4	54	1	0	0	0	0	1	0	0	0	11734	913	32	1	1642	1	PET112L	4	152682052	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	12035110	152682052	38472224	313	15091										
KIAA0922	23240	broad.mit.edu	37	chr4	154517430	154517430	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtacgcattctgaggaatcCaggtttggcatcctccactt	10	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:154517430C>T	uc003inm.3	+	20	2065	c.2013C>T	c.(2011-2013)TCC>TCT	p.S671S	KIAA0922_uc010ipp.2_Silent_p.S672S|KIAA0922_uc010ipq.2_Silent_p.S440S	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	671	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CTGAGGAATCCAGGTTTGGCA	0.413													0	0	0	0.00245	0	12	89										T	154517430	C	T	154517430	2	4	54	1	0	0	0	0	0	0	0	1	8201	581	21	2		2	KIAA0922	4	154517430	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1835378	154517430	36636846	314	15092										
PALLD	23022	broad.mit.edu	37	chr4	169602528	169602528	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgaaagtttagctttcaaatCaagagctggagctatgccac	9	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:169602528C>G	uc011cjx.1	+	4	1344	c.1133C>G	c.(1132-1134)TCA>TGA	p.S378*	PALLD_uc003iru.2_Nonsense_Mutation_p.S378*|PALLD_uc003irv.2_Translation_Start_Site	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	378					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		GCTTTCAAATCAAGAGCTGGA	0.373									Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.008291	0	8	54										G	169602528	C	G	169602528	4	3	54	1	0	0	0	0	0	1	0	0	11407	838	29	1	1143	1	PALLD	4	169602528	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	15085098	169602528	21551748	315	15093										
GALNTL6	442117	broad.mit.edu	37	chr4	173269825	173269825	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagaaatcattctagtagatGacttcagtgagagaggtaag	11	5	3	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:173269825G>A	uc003isv.2	+	5	1274	c.538G>A	c.(538-540)GAC>AAC	p.D180N		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	180	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						TCTAGTAGATGACTTCAGTGA	0.383													0	0	0	0.001984	0	5	46										A	173269825	G	A	173269825	3	1	54	1	0	0	0	0	1	0	0	0	6225	1290	45	1	552	1	GALNTL6	4	173269825	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3667297	173269825	17884451	316	15094										
MORF4	10934	broad.mit.edu	37	chr4	174537452	174537452	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attatctgtgtttccatgagAtttcttgtaatttgcatagt	7	5	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:174537452A>G	uc011cke.1	-	1	343	c.343T>C	c.(343-345)TCT>CCT	p.S115P		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TTTCCATGAGATTTCTTGTAA	0.398													0	0	0	0.001855	0	13	104										G	174537452	A	G	174537452	3	3	54	1	0	0	0	0	1	0	0	0	9705	333	12	5	367	5	MORF4	4	174537452	Missense_Mutation	SNP	A	TCGA-DK-A2I4-01A-11D-A21A-08	1267627	174537452	16616824	317	15095										
SNX25	83891	broad.mit.edu	37	chr4	186274687	186274687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagattatggtgatgatgtgGatgggaggaaagacgccttg	16	4	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:186274687G>A	uc003ixh.2	+	15	2212	c.2023G>A	c.(2023-2025)GAT>AAT	p.D675N	SNX25_uc010ish.2_Missense_Mutation_p.D391N|SNX25_uc003ixi.2_Missense_Mutation_p.D179N	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	675					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		TGATGATGTGGATGGGAGGAA	0.418													0	0	0	0.010729	0	10	72										A	186274687	G	A	186274687	3	1	54	1	0	0	0	0	1	0	0	0	14896	1174	41	1	2077	1	SNX25	4	186274687	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	11737235	186274687	4879589	318	15096										
LRP2BP	55805	broad.mit.edu	37	chr4	186295477	186295477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctcaggtaggattacctttCagcttcctcatttgatcgtt	7	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr4:186295477C>T	uc003ixj.1	-	4	1281	c.469G>A	c.(469-471)GAA>AAA	p.E157K	LRP2BP_uc003ixk.1_Missense_Mutation_p.E131K|LRP2BP_uc011ckr.1_Missense_Mutation_p.E157K	NM_018409	NP_060879	Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	157	Sel1-like 2.					cytoplasm	protein binding				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		GATTACCTTTCAGCTTCCTCA	0.413													0	0	0	0.001984	0	5	72										T	186295477	C	T	186295477	3	4	54	1	0	0	0	0	1	0	0	0	8957	835	29	1	594	1	LRP2BP	4	186295477	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	20790	186295477	4858799	319	15097										
PLEKHG4B	153478	broad.mit.edu	37	chr5	155046	155046	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgttgacagctgccagctGaccgcagacctcgacggctc	11	14	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:155046G>A	uc003jak.2	+	6	1031	c.981G>A	c.(979-981)CTG>CTA	p.L327L		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	327					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GCTGCCAGCTGACCGCAGACC	0.572													0	0	0	0.005443	0	24	92										A	155046	G	A	155046	2	1	54	1	0	0	0	0	0	0	0	1	12072	1277	45	1		1	PLEKHG4B	5	155046	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		155046	180760214	320	15098										
ADAMTS16	170690	broad.mit.edu	37	chr5	5239963	5239963	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaattttcgggcactactttCgactacagacggtcctataa	7	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:5239963C>T	uc003jdl.2	+	16	2586	c.2448C>T	c.(2446-2448)TTC>TTT	p.F816F	ADAMTS16_uc003jdk.1_Silent_p.F816F	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	816	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GCACTACTTTCGACTACAGAC	0.517													0	0	0	0.00278	0	19	131										T	5239963	C	T	5239963	2	4	54	1	0	0	0	0	0	0	0	1	261	883	31	1		1	ADAMTS16	5	5239963	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5084917	5239963	175675297	321	15099										
NSUN2	54888	broad.mit.edu	37	chr5	6605470	6605470	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttttcttcccttctgtagtCcgagttaacaaattcatcct	4	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:6605470C>T	uc003jdu.2	-	15	1718	c.1653G>A	c.(1651-1653)CGG>CGA	p.R551R	NSUN2_uc003jds.2_5'Flank|NSUN2_uc003jdt.2_Silent_p.R315R|NSUN2_uc011cmk.1_Silent_p.R516R|NSUN2_uc003jdv.2_Silent_p.R315R	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	551						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						CTTCTGTAGTCCGAGTTAACA	0.413													0	0	0	0.001368	0	13	126										T	6605470	C	T	6605470	2	4	54	1	0	0	0	0	0	0	0	1	10678	842	30	1		1	NSUN2	5	6605470	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1365507	6605470	174309790	322	15100										
FAM105A	54491	broad.mit.edu	37	chr5	14601215	14601215	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccggaggctacatttatattCagggcacaagctgaaatggt	11	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:14601215C>T	uc003jfj.2	+	2	319	c.206C>T	c.(205-207)TCA>TTA	p.S69L		NM_019018	NP_061891	Q9NUU6	F105A_HUMAN	hypothetical protein LOC54491	69										ovary(1)	1	Lung NSC(4;0.00592)					CATTTATATTCAGGGCACAAG	0.398													0	0	0	0.004656	0	22	208										T	14601215	C	T	14601215	3	4	54	1	0	0	0	0	1	0	0	0	5387	838	29	1	212	1	FAM105A	5	14601215	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7995745	14601215	166314045	323	15101										
RNASEN	29102	broad.mit.edu	37	chr5	31515224	31515224	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctcgggctctttttccttGattgaggtatagttcttgtc	9	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:31515224G>C	uc003jhg.2	-	7	1520	c.1161C>G	c.(1159-1161)ATC>ATG	p.I387M	RNASEN_uc003jhh.2_Missense_Mutation_p.I350M|RNASEN_uc003jhi.2_Missense_Mutation_p.I350M|RNASEN_uc010iui.1_Missense_Mutation_p.I310M	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	387					gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						CTTTTTCCTTGATTGAGGTAT	0.468													0	0	0	0.001984	0	7	65										C	31515224	G	C	31515224	3	2	54	1	0	0	0	0	1	0	0	0	13417	1280	45	1	3079	1	RNASEN	5	31515224	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	16914009	31515224	149400036	324	15102										
MTMR12	54545	broad.mit.edu	37	chr5	32229910	32229910	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcccctaggtccacgaactCatcttctcgtttggccaaat	6	14	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:32229910C>G	uc003jhq.2	-	16	2388	c.2218G>C	c.(2218-2220)GAG>CAG	p.E740Q	MTMR12_uc010iuk.2_Missense_Mutation_p.E686Q|MTMR12_uc010iul.2_Missense_Mutation_p.E630Q	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	740						cytoplasm	phosphatase activity			ovary(1)	1						TCCACGAACTCATCTTCTCGT	0.507													0	0	0	0.003163	0	14	104										G	32229910	C	G	32229910	3	3	54	1	0	0	0	0	1	0	0	0	9941	835	29	1	29	1	MTMR12	5	32229910	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	714686	32229910	148685350	325	15103										
RXFP3	51289	broad.mit.edu	37	chr5	33937059	33937059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccgggcagcggcggggcaGagagcgcggacacagaggcc	19	14	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:33937059G>C	uc003jic.1	+	1	571	c.214G>C	c.(214-216)GAG>CAG	p.E72Q		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	72	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CGGCGGGGCAGAGAGCGCGGA	0.692													0	0	0	0.001368	0	10	142										C	33937059	G	C	33937059	3	2	54	1	0	0	0	0	1	0	0	0	13761	943	33	1	216	1	RXFP3	5	33937059	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1707149	33937059	146978201	326	15104										
UGT3A2	167127	broad.mit.edu	37	chr5	36035959	36035959	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctgaaagacatagggcttGaggtgcgtcgcgccccctgt	14	11	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:36035959G>A	uc003jjz.1	-	7	1506	c.1413C>T	c.(1411-1413)CTC>CTT	p.L471L	UGT3A2_uc011cos.1_Silent_p.L437L|UGT3A2_uc011cot.1_Silent_p.L169L	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	471	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATAGGGCTTGAGGTGCGTCG	0.617													0	0	0	0.00499	0	13	54										A	36035959	G	A	36035959	2	1	54	1	0	0	0	0	0	0	0	1	16961	1277	45	1		1	UGT3A2	5	36035959	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2098900	36035959	144879301	327	15105										
SLC1A3	6507	broad.mit.edu	37	chr5	36677231	36677231	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aacaggggcaggccctgagaGagttctttgattctcttaac	11	9	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:36677231G>C	uc003jkj.3	+	6	1281	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	SLC1A3_uc011cox.1_Missense_Mutation_p.E162Q|SLC1A3_uc010iuy.2_Missense_Mutation_p.E269Q	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	269					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	GGCCCTGAGAGAGTTCTTTGA	0.413													0	0	0	0.000602	0	4	57										C	36677231	G	C	36677231	3	2	54	1	0	0	0	0	1	0	0	0	14433	943	33	1	840	1	SLC1A3	5	36677231	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	641272	36677231	144238029	328	15106										
C5orf42	65250	broad.mit.edu	37	chr5	37174003	37174003	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attgactccatttgatatcaGaagtggaactgaggaagatt	10	5	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:37174003G>A	uc011cpa.1	-	32	6256	c.6025C>T	c.(6025-6027)CTG>TTG	p.L2009L	C5orf42_uc011coy.1_Silent_p.L509L|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.L1084L|C5orf42_uc003jkr.1_Silent_p.L42L	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2009										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TTTGATATCAGAAGTGGAACT	0.373													0	0	0	0.000602	0	3	55										A	37174003	G	A	37174003	2	1	54	1	0	0	0	0	0	0	0	1	2301	933	33	1		1	C5orf42	5	37174003	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	496772	37174003	143741257	329	15107										
SNX18	112574	broad.mit.edu	37	chr5	53813855	53813855	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agatctcgctgcgagagcacGaggtgctgagcctgtgcagc	15	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:53813855G>A	uc003jpj.3	+	1	263	c.73G>A	c.(73-75)GAG>AAG	p.E25K	SNX18_uc011cqg.1_Missense_Mutation_p.E25K|SNX18_uc003jpi.3_Missense_Mutation_p.E25K	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	25	SH3.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				GCGAGAGCACGAGGTGCTGAG	0.706													0	0	0	0.004672	0	3	14										A	53813855	G	A	53813855	3	1	54	1	0	0	0	0	1	0	0	0	14889	1059	37	1	75	1	SNX18	5	53813855	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	16639852	53813855	127101405	330	15108										
ANKRD55	79722	broad.mit.edu	37	chr5	55407501	55407501	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggatccttctgatgggctctCtgctcttctttcttgttttt	8	10	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:55407501C>T	uc003jqu.2	-	10	1226	c.1074G>A	c.(1072-1074)CAG>CAA	p.Q358Q	ANKRD55_uc003jqt.2_Silent_p.Q70Q	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	357										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GATGGGCTCTCTGCTCTTCTT	0.522													0	0	0	0.00245	0	13	130										T	55407501	C	T	55407501	2	4	54	1	0	0	0	0	0	0	0	1	681	912	32	1		1	ANKRD55	5	55407501	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1593646	55407501	125507759	331	15109										
MAP3K1	4214	broad.mit.edu	37	chr5	56178366	56178366	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccagtgacgagacagtgttCaccccagtagaggagaaatg	12	10	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:56178366C>T	uc003jqw.3	+	14	3840	c.3339C>T	c.(3337-3339)TTC>TTT	p.F1113F		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1113					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AGACAGTGTTCACCCCAGTAG	0.433													0	0	0	0.004482	0	6	48										T	56178366	C	T	56178366	2	4	54	1	0	0	0	0	0	0	0	1	9243	825	29	1		1	MAP3K1	5	56178366	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	770865	56178366	124736894	332	15110										
ELOVL7	79993	broad.mit.edu	37	chr5	60050591	60050591	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aatgatgcacgcaaagactgGaaactgatacttgcaatcct	8	9	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:60050591G>T	uc003jsi.3	-	9	906	c.706C>A	c.(706-708)CCA>ACA	p.P236T	ELOVL7_uc011cqo.1_Missense_Mutation_p.P149T|ELOVL7_uc010iwk.2_Missense_Mutation_p.P236T|ELOVL7_uc003jsj.3_Missense_Mutation_p.P223T	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	236					fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				GCAAAGACTGGAAACTGATAC	0.393													1	0	0.00116845	0.001168	0.00119519	5	23										T	60050591	G	T	60050591	3	4	54	1	0	0	0	0	1	0	0	0	5079	1174	41	3	143	3	ELOVL7	5	60050591	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3872225	60050591	120864669	333	15111										
HTR1A	3350	broad.mit.edu	37	chr5	63257087	63257087	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgagcgagatgagcgcagCggcgcgccggggcgtcctct	18	12	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:63257087C>T	uc011cqt.1	-	1	460	c.460G>A	c.(460-462)GCT>ACT	p.A154T		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	154	Helical; Name=4; (By similarity).			RAA -> PR (in Ref. 1; AAA36440/CAA31908).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGAGCGCAGCGGCGCGCCGG	0.647													0	0	0	0.004007	0	17	60										T	63257087	C	T	63257087	3	4	54	1	0	0	0	0	1	0	0	0	7436	768	27	2	811	2	HTR1A	5	63257087	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3206496	63257087	117658173	334	15112										
BDP1	55814	broad.mit.edu	37	chr5	70860685	70860685	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaatatttcttcaatgatatCttcattgaagtggatgaaac	7	5	4	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:70860685C>G	uc003kbp.1	+	39	8111	c.7848C>G	c.(7846-7848)ATC>ATG	p.I2616M	BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2616					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TCAATGATATCTTCATTGAAG	0.368													0	0	0	0.00308	0	8	73										G	70860685	C	G	70860685	3	3	54	1	0	0	0	0	1	0	0	0	1395	903	32	1	8002	1	BDP1	5	70860685	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7603598	70860685	110054575	335	15113										
MAP1B	4131	broad.mit.edu	37	chr5	71492567	71492567	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctactattgagatatccagtGagcccacccccatggatgag	9	12	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:71492567G>A	uc003kbw.3	+	5	3626	c.3385G>A	c.(3385-3387)GAG>AAG	p.E1129K	MAP1B_uc010iyw.1_Missense_Mutation_p.E1146K|MAP1B_uc010iyx.1_Missense_Mutation_p.E1003K|MAP1B_uc010iyy.1_Missense_Mutation_p.E1003K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1129						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GATATCCAGTGAGCCCACCCC	0.512													0	0	0	0.004482	0	6	42										A	71492567	G	A	71492567	3	1	54	1	0	0	0	0	1	0	0	0	9228	1291	45	1	3403	1	MAP1B	5	71492567	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	631882	71492567	109422693	336	15114										
S100Z	170591	broad.mit.edu	37	chr5	76171199	76171199	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccgacatgcccacccagctCgagatggccatggacaccat	10	16	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:76171199C>T	uc003kep.1	+	3	345	c.15C>T	c.(13-15)CTC>CTT	p.L5L	S100Z_uc003keq.3_Silent_p.L5L	NM_130772	NP_570128	Q8WXG8	S100Z_HUMAN	S100 calcium binding protein Z	5							calcium ion binding			ovary(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;8.91e-51)|Epithelial(54;5.43e-45)|all cancers(79;1.82e-40)		CCACCCAGCTCGAGATGGCCA	0.522													0	0	0	0.001168	0	5	27										T	76171199	C	T	76171199	2	4	54	1	0	0	0	0	0	0	0	1	13792	871	31	1		1	S100Z	5	76171199	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4678632	76171199	104744061	337	15115										
SPZ1	84654	broad.mit.edu	37	chr5	79616517	79616517	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcagcccacaaagaaaatatCagaggacttgacaaaatcaa	6	9	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:79616517C>G	uc003kgn.2	+	1	728	c.483C>G	c.(481-483)ATC>ATG	p.I161M	uc011ctk.1_Intron	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAGAAAATATCAGAGGACTTG	0.373													0	0	0	0.001168	0	4	35										G	79616517	C	G	79616517	3	3	54	1	0	0	0	0	1	0	0	0	15126	816	29	1	485	1	SPZ1	5	79616517	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3445318	79616517	101298743	338	15116										
APC	324	broad.mit.edu	37	chr5	112174757	112174757	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagaagaacagcatgaagaaGaagagagaccaacaaattat	9	5	0	7			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:112174757G>T	uc010jby.2	+	16	3846	c.3466G>T	c.(3466-3468)GAA>TAA	p.E1156*	APC_uc011cvt.1_Nonsense_Mutation_p.E1138*|APC_uc003kpz.3_Nonsense_Mutation_p.E1156*|APC_uc003kpy.3_Nonsense_Mutation_p.E1156*|APC_uc010jbz.2_Nonsense_Mutation_p.E873*|APC_uc010jca.2_Nonsense_Mutation_p.E456*	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1156	Ser-rich.|Responsible for down-regulation through a process mediated by direct ubiquitination.|Asp/Glu-rich (acidic).				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1156fs*8(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GCATGAAGAAGAAGAGAGACC	0.338		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			1	0	3.59834e-05	0.001168	3.71589e-05	6	20										T	112174757	G	T	112174757	4	4	54	1	0	0	0	0	0	1	0	0	763	943	33	3	3524	3	APC	5	112174757	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	32558240	112174757	68740503	339	15117										
ZNF608	57507	broad.mit.edu	37	chr5	124036729	124036729	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttctgtttcatgccacacGatcccttccaaattcacact	3	15	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:124036729G>A	uc003ktq.1	-	2	1263	c.1140C>T	c.(1138-1140)ATC>ATT	p.I380I	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Silent_p.I380I|ZNF608_uc003ktt.1_Silent_p.I380I	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	380						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CATGCCACACGATCCCTTCCA	0.443													0	0	0	0.009096	0	3	71										A	124036729	G	A	124036729	2	1	54	1	0	0	0	0	0	0	0	1	18031	1048	37	1		1	ZNF608	5	124036729	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	11861972	124036729	56878531	340	15118										
CDKN2AIPNL	91368	broad.mit.edu	37	chr5	133747454	133747454	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccattgcttctcgctctctGagtaggagcggaactgctcc	10	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:133747454G>C	uc011cxs.1	-	1	136	c.92C>G	c.(91-93)TCA>TGA	p.S31*	CDKN2AIPNL_uc003kzi.1_Nonsense_Mutation_p.S31*	NM_080656	NP_542387	Q96HQ2	C2AIL_HUMAN	CDKN2A interacting protein N-terminal like	31											0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTCGCTCTCTGAGTAGGAGCG	0.697											OREG0016789	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	6	33										C	133747454	G	C	133747454	4	2	54	1	0	0	0	0	0	1	0	0	3163	1294	45	1	270	1	CDKN2AIPNL	5	133747454	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9710725	133747454	47167806	341	15119										
SEC24A	10802	broad.mit.edu	37	chr5	134022530	134022530	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgtatttgatgtgtctcaCaatgcagtcgaaactggata	9	6	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:134022530C>G	uc003kzs.2	+	10	1830	c.1542C>G	c.(1540-1542)CAC>CAG	p.H514Q	SEC24A_uc011cxu.1_Missense_Mutation_p.H278Q	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	514					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATGTGTCTCACAATGCAGTCG	0.333													0	0	0	0.001168	0	4	73										G	134022530	C	G	134022530	3	3	54	1	0	0	0	0	1	0	0	0	13994	477	17	4	1580	4	SEC24A	5	134022530	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	275076	134022530	46892730	342	15120										
SEC24A	10802	broad.mit.edu	37	chr5	134032871	134032871	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaattagccttggactgttCtggtcagcaagttgctgttg	12	7	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:134032871C>G	uc003kzs.2	+	14	2330	c.2042C>G	c.(2041-2043)TCT>TGT	p.S681C	SEC24A_uc011cxu.1_Missense_Mutation_p.S445C	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	681					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGACTGTTCTGGTCAGCAA	0.328													0	0	0	0.003163	0	12	89										G	134032871	C	G	134032871	3	3	54	1	0	0	0	0	1	0	0	0	13994	913	32	1	2096	1	SEC24A	5	134032871	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10341	134032871	46882389	343	15121										
MATR3	9782	broad.mit.edu	37	chr5	138643642	138643642	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacctagggatgattgggaaGaaaaaaggcactttagaaga	12	4	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:138643642G>A	uc003ldu.2	+	5	965	c.538G>A	c.(538-540)GAA>AAA	p.E180K	MATR3_uc003lds.2_Missense_Mutation_p.E180K|MATR3_uc010jfb.2_Missense_Mutation_p.E180K|MATR3_uc003ldt.2_Intron|MATR3_uc003ldw.2_Missense_Mutation_p.E180K|MATR3_uc003ldx.2_Missense_Mutation_p.E180K|MATR3_uc010jfc.2_Missense_Mutation_p.E180K|MATR3_uc003ldy.2_Intron|MATR3_uc011czb.1_Intron|MATR3_uc003ldz.2_Missense_Mutation_p.E180K|MATR3_uc003lea.2_Missense_Mutation_p.E180K	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	180						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGATTGGGAAGAAAAAAGGCA	0.453													0	0	0	0.00308	0	6	30										A	138643642	G	A	138643642	3	1	54	1	0	0	0	0	1	0	0	0	9337	943	33	1	540	1	MATR3	5	138643642	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4610771	138643642	42271618	344	15122										
PCDHB1	29930	broad.mit.edu	37	chr5	140432123	140432123	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctctgtgtccagcccactCcctgaagactcaccaccaca	5	19	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:140432123C>A	uc003lik.1	+	1	1145	c.1068C>A	c.(1066-1068)CTC>CTA	p.L356L		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	356	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCAGCCCACTCCCTGAAGACT	0.537													1	0	4.3838e-07	0.001855	4.58548e-07	11	80										A	140432123	C	A	140432123	2	1	54	1	0	0	0	0	0	0	0	1	11534	842	30	3		3	PCDHB1	5	140432123	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1788481	140432123	40483137	345	15123										
PCDHB13	56123	broad.mit.edu	37	chr5	140594403	140594403	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacatcgaagtcctggatgtCaacgataatgcccctgaatt	8	10	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:140594403C>T	uc003lja.1	+	1	895	c.708C>T	c.(706-708)GTC>GTT	p.V236V		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	236	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCTGGATGTCAACGATAATG	0.532													0	0	0	0.004656	0	20	189										T	140594403	C	T	140594403	2	4	54	1	0	0	0	0	0	0	0	1	11538	813	29	1		1	PCDHB13	5	140594403	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	162280	140594403	40320857	346	15124										
PCDHGA4	56111	broad.mit.edu	37	chr5	140736611	140736611	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actcaagtccagcgagccggGactatttgcagtggggctgc	14	11	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:140736611G>A	uc003ljq.1	+	1	1844	c.1844G>A	c.(1843-1845)GGA>GAA	p.G615E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.G615E	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	615	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGAGCCGGGACTATTTGCA	0.617													0	0	0	0.00499	0	14	68										A	140736611	G	A	140736611	3	1	54	1	0	0	0	0	1	0	0	0	11556	1174	41	1	1846	1	PCDHGA4	5	140736611	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	142208	140736611	40178649	347	15125										
PCDHGB3	56102	broad.mit.edu	37	chr5	140750571	140750571	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagcacccctggacagggaaGagcagccacatcaccacctg	10	15	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:140750571G>A	uc003ljw.1	+	1	610	c.610G>A	c.(610-612)GAG>AAG	p.E204K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.E204K	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	204	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACAGGGAAGAGCAGCCACA	0.552													0	0	0	0.006214	0	10	48										A	140750571	G	A	140750571	3	1	54	1	0	0	0	0	1	0	0	0	11564	943	33	1	612	1	PCDHGB3	5	140750571	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	13960	140750571	40164689	348	15126										
PCDHGA6	56109	broad.mit.edu	37	chr5	140753992	140753992	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atccttgtcgaggataaactGaatctttatcccgtggaagt	9	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:140753992G>A	uc003ljy.1	+	1	342	c.342G>A	c.(340-342)CTG>CTA	p.L114L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.L114L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	114	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGATAAACTGAATCTTTATC	0.483													0	0	0	0.008871	0	16	70										A	140753992	G	A	140753992	2	1	54	1	0	0	0	0	0	0	0	1	11558	1277	45	1		1	PCDHGA6	5	140753992	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3421	140753992	40161268	349	15127										
PCDHGB5	56101	broad.mit.edu	37	chr5	140779098	140779098	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctcctggggcctccatcgcGcaagtctgcgcctcggacct	11	18	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:140779098G>A	uc003lkf.1	+	1	1404	c.1404G>A	c.(1402-1404)GCG>GCA	p.A468A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.A468A	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	468	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCCATCGCGCAAGTCTGCG	0.567													0	0	0	0.000602	0	4	37										A	140779098	G	A	140779098	2	1	54	1	0	0	0	0	0	0	0	1	11566	1074	38	2		2	PCDHGB5	5	140779098	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	25106	140779098	40136162	350	15128										
PCDH12	51294	broad.mit.edu	37	chr5	141325351	141325351	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggccgggtcaggggcgctCagccggtccagggccagacc	17	15	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:141325351C>T	uc003llx.2	-	4	4361	c.3150G>A	c.(3148-3150)CTG>CTA	p.L1050L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	1050	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGGGCGCTCAGCCGGTCCA	0.677													0	0	0	0.007413	0	16	116										T	141325351	C	T	141325351	2	4	54	1	0	0	0	0	0	0	0	1	11510	813	29	1		1	PCDH12	5	141325351	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	546253	141325351	39589909	351	15129										
FGF1	2246	broad.mit.edu	37	chr5	141974881	141974881	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaagagactggcagggggaGaaacaagattgctttctggc	15	6	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:141974881G>A	uc003lmm.2	-	4	522	c.442C>T	c.(442-444)CTC>TTC	p.L148F	FGF1_uc011dbi.1_3'UTR|FGF1_uc003lmn.3_Missense_Mutation_p.L148F|FGF1_uc003lmp.3_3'UTR|FGF1_uc003lmq.2_Missense_Mutation_p.L148F|FGF1_uc010jgj.2_Missense_Mutation_p.L147F|FGF1_uc003lmr.2_Missense_Mutation_p.L148F|FGF1_uc003lms.3_Missense_Mutation_p.L148F	NM_001144892	NP_001138364	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic) isoform 1	148					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	GGCAGGGGGAGAAACAAGATT	0.493													0	0	0	0.008291	0	7	37										A	141974881	G	A	141974881	3	1	54	1	0	0	0	0	1	0	0	0	5838	942	33	1	29	1	FGF1	5	141974881	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	649530	141974881	38940379	352	15130										
SH3TC2	79628	broad.mit.edu	37	chr5	148411215	148411215	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagggccaacagggagcatCtctcctcatcactgagaaag	10	13	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:148411215C>T	uc003lpu.2	-	9	1189	c.1037G>A	c.(1036-1038)AGA>AAA	p.R346K	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_5'UTR|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.R339K|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.R231K	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	346							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGGAGCATCTCTCCTCATC	0.522													0	0	0	0.001368	0	10	52										T	148411215	C	T	148411215	3	4	54	1	0	0	0	0	1	0	0	0	14262	913	32	1	2865	1	SH3TC2	5	148411215	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6436334	148411215	32504045	353	15131										
TCOF1	6949	broad.mit.edu	37	chr5	149754546	149754546	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcagggaaggccccccaggtCagagccgcctcggcccctgc	13	18	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:149754546C>T	uc003lry.2	+	10	1416	c.1308C>T	c.(1306-1308)GTC>GTT	p.V436V	TCOF1_uc003lrw.2_Silent_p.V436V|TCOF1_uc011dch.1_Silent_p.V436V|TCOF1_uc003lrz.2_Silent_p.V436V|TCOF1_uc003lrx.2_Silent_p.V359V|TCOF1_uc003lsa.2_Silent_p.V359V|TCOF1_uc011dci.1_5'Flank	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	436					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCCCCAGGTCAGAGCCGCCT	0.662													0	0	0	0.001168	0	5	31										T	149754546	C	T	149754546	2	4	54	1	0	0	0	0	0	0	0	1	15705	813	29	1		1	TCOF1	5	149754546	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1343331	149754546	31160714	354	15132										
DCTN4	51164	broad.mit.edu	37	chr5	150110697	150110697	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctcaatctttatctctttCtgatcctctccttctttaag	4	12	6	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:150110697C>T	uc003lsv.2	-	7	735	c.633G>A	c.(631-633)CAG>CAA	p.Q211Q	DCTN4_uc003lsu.2_Silent_p.Q154Q|DCTN4_uc010jhi.2_Silent_p.Q218Q|DCTN4_uc010jhj.2_RNA	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	211						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTATCTCTTTCTGATCCTCTC	0.343													0	0	0	0.004482	0	8	33										T	150110697	C	T	150110697	2	4	54	1	0	0	0	0	0	0	0	1	4309	912	32	1		1	DCTN4	5	150110697	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	356151	150110697	30804563	355	15133										
FAT2	2196	broad.mit.edu	37	chr5	150947809	150947809	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccattgccctcagagattttCcgcatgcggtccacagctag	9	14	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:150947809C>T	uc003lue.3	-	1	697	c.684G>A	c.(682-684)CGG>CGA	p.R228R	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.R228R	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	228	Cadherin 2.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGAGATTTTCCGCATGCGGT	0.597													0	0	0	0.004482	0	8	34										T	150947809	C	T	150947809	2	4	54	1	0	0	0	0	0	0	0	1	5690	842	30	1		1	FAT2	5	150947809	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	837112	150947809	29967451	356	15134										
GEMIN5	25929	broad.mit.edu	37	chr5	154308188	154308188	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctataccccctcctcttctCttcagaaagggcaatttcaa	4	14	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:154308188C>T	uc003lvx.3	-	6	896	c.813G>A	c.(811-813)AAG>AAA	p.K271K	GEMIN5_uc011ddk.1_Silent_p.K270K	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	271					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CTCCTCTTCTCTTCAGAAAGG	0.473													0	0	0	0.001855	0	11	63										T	154308188	C	T	154308188	2	4	54	1	0	0	0	0	0	0	0	1	6331	912	32	1		1	GEMIN5	5	154308188	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3360379	154308188	26607072	357	15135										
GABRP	2568	broad.mit.edu	37	chr5	170222427	170222427	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcacggtcctgtatgccctCaggtacgcggacacctgtga	13	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:170222427C>G	uc003mau.2	+	5	654	c.456C>G	c.(454-456)CTC>CTG	p.L152L	GABRP_uc011dev.1_Silent_p.L152L	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	152	Extracellular (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTATGCCCTCAGGTACGCGG	0.532													0	0	0	0.004482	0	9	79										G	170222427	C	G	170222427	2	3	54	1	0	0	0	0	0	0	0	1	6174	813	29	1		1	GABRP	5	170222427	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	15914239	170222427	10692833	358	15136										
BOD1	91272	broad.mit.edu	37	chr5	173040145	173040145	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttacttactgaaccacactCtgcctcagaccatttcgcaa	4	15	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:173040145C>T	uc003mcq.2	-	2	578	c.351G>A	c.(349-351)CAG>CAA	p.Q117Q	BOD1_uc003mcr.2_Silent_p.Q117Q	NM_138369	NP_612378	Q96IK1	BOD1_HUMAN	biorientation of chromosomes in cell division 1	117					cell division|mitosis	condensed chromosome kinetochore|microtubule organizing center				ovary(2)	2						GAACCACACTCTGCCTCAGAC	0.423													0	0	0	0.003954	0	22	166										T	173040145	C	T	173040145	2	4	54	1	0	0	0	0	0	0	0	1	1482	912	32	1		1	BOD1	5	173040145	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2817718	173040145	7875115	359	15137										
RAB24	53917	broad.mit.edu	37	chr5	176730193	176730193	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttctgataaggccccaccaGaaagcggtcgtgcacgtagc	12	12	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr5:176730193G>C	uc003mfv.2	-	2	466	c.97C>G	c.(97-99)CTG>GTG	p.L33V	RAB24_uc003mfu.2_5'UTR|RAB24_uc003mfw.2_Missense_Mutation_p.L33V|PRELID1_uc003mfx.2_5'Flank|PRELID1_uc003mfy.2_5'Flank	NM_130781	NP_570137	Q969Q5	RAB24_HUMAN	RAB24 gene product	33					autophagy|protein transport|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|protein binding				0	all_cancers(89;2.49e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGCCCCACCAGAAAGCGGTCG	0.647													0	0	0	0.009535	0	25	156										C	176730193	G	C	176730193	3	2	54	1	0	0	0	0	1	0	0	0	12911	933	33	1	546	1	RAB24	5	176730193	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3690048	176730193	4185067	360	15138										
FOXQ1	94234	broad.mit.edu	37	chr6	1313343	1313343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgccatggccatccgcgactCggcgggcgggcgcttgacgc	16	16	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:1313343C>T	uc003mtl.3	+	1	669	c.404C>T	c.(403-405)TCG>TTG	p.S135L		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	135	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ATCCGCGACTCGGCGGGCGGG	0.592													0	0	0	0.006214	0	7	71										T	1313343	C	T	1313343	3	4	54	1	0	0	0	0	1	0	0	0	6030	893	31	1	406	1	FOXQ1	6	1313343	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08		1313343	169801724	361	15139										
SLC22A23	63027	broad.mit.edu	37	chr6	3285315	3285315	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacgcgcttgggactcacctGagtctgggtgctggctgtac	14	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:3285315G>C	uc003mvm.3	-	8	1577	c.1577C>G	c.(1576-1578)TCA>TGA	p.S526*	uc003mvi.1_Intron|SLC22A23_uc003mvn.3_Nonsense_Mutation_p.S245*|SLC22A23_uc003mvo.3_Nonsense_Mutation_p.S245*|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Nonsense_Mutation_p.S526*	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	526					ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				GGACTCACCTGAGTCTGGGTG	0.527													0	0	0	0.009096	0	3	32										C	3285315	G	C	3285315	4	2	54	1	0	0	0	0	0	1	0	0	14452	1294	45	1	495	1	SLC22A23	6	3285315	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1971972	3285315	167829752	362	15140										
SYCP2L	221711	broad.mit.edu	37	chr6	10911094	10911094	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtattgctgcttttgctgatGagcatgaggtatgttcatcc	11	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:10911094G>A	uc003mzo.2	+	12	1206	c.910G>A	c.(910-912)GAG>AAG	p.E304K	SYCP2L_uc011din.1_Missense_Mutation_p.E145K|SYCP2L_uc010jow.2_Intron	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	304						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TTTTGCTGATGAGCATGAGGT	0.403													0	0	0	0.00632	0	20	303										A	10911094	G	A	10911094	3	1	54	1	0	0	0	0	1	0	0	0	15430	1291	45	1	956	1	SYCP2L	6	10911094	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7625779	10911094	160203973	363	15141										
NEDD9	4739	broad.mit.edu	37	chr6	11190713	11190713	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acagctcccttgacaaagtgGaggtactccttcaggaacag	10	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:11190713G>C	uc003mzv.2	-	5	1556	c.1389C>G	c.(1387-1389)CTC>CTG	p.L463L	NEDD9_uc010joz.2_Silent_p.L463L|NEDD9_uc003mzw.3_Silent_p.L317L	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	463					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			TGACAAAGTGGAGGTACTCCT	0.522													0	0	0	0.001984	0	5	67										C	11190713	G	C	11190713	2	2	54	1	0	0	0	0	0	0	0	1	10313	1161	41	1		1	NEDD9	6	11190713	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	279619	11190713	159924354	364	15142										
JARID2	3720	broad.mit.edu	37	chr6	15512483	15512483	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggggatcaaggtgcacagGaccgtgcagcagagtggcca	17	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:15512483G>C	uc003nbj.2	+	14	3241	c.2997G>C	c.(2995-2997)AGG>AGC	p.R999S	JARID2_uc011div.1_Missense_Mutation_p.R827S	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	999	JmjC.				central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AGGTGCACAGGACCGTGCAGC	0.607													0	0	0	0.001368	0	12	87										C	15512483	G	C	15512483	3	2	54	1	0	0	0	0	1	0	0	0	7945	1165	41	1	3051	1	JARID2	6	15512483	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4321770	15512483	155602584	365	15143										
FAM8A1	51439	broad.mit.edu	37	chr6	17600696	17600696	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcccgggcaggacgatggcgGaggggaccacgagcccgtcc	17	14	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:17600696G>A	uc003ncc.2	+	1	179	c.56G>A	c.(55-57)GGA>GAA	p.G19E		NM_016255	NP_057339	Q9UBU6	FA8A1_HUMAN	family with sequence similarity 8, member A1	19						integral to membrane					0	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)			GACGATGGCGGAGGGGACCAC	0.736													0	0	0	0.008291	0	10	14										A	17600696	G	A	17600696	3	1	54	1	0	0	0	0	1	0	0	0	5649	1174	41	1	58	1	FAM8A1	6	17600696	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2088213	17600696	153514371	366	15144										
NUP153	9972	broad.mit.edu	37	chr6	17675981	17675981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacatctggataatttgaagCagtactagttgttgaaggtt	10	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:17675981C>T	uc003ncd.1	-	3	555	c.355G>A	c.(355-357)GCT>ACT	p.A119T	NUP153_uc011dje.1_Missense_Mutation_p.A119T|NUP153_uc010jpl.1_Missense_Mutation_p.A119T	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	119					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TAATTTGAAGCAGTACTAGTT	0.358													0	0	0	0.000602	0	5	69										T	17675981	C	T	17675981	3	4	54	1	0	0	0	0	1	0	0	0	10755	710	25	2	4152	2	NUP153	6	17675981	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	75285	17675981	153439086	367	15145										
FAM65B	9750	broad.mit.edu	37	chr6	24865637	24865637	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attttgctggcaccatcctgGaggcgtcgctggatacaata	11	10	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:24865637G>C	uc003neo.1	-	7	632	c.456C>G	c.(454-456)CTC>CTG	p.L152L	FAM65B_uc011djs.1_Silent_p.L181L|FAM65B_uc011dju.1_Silent_p.L186L|FAM65B_uc003nep.2_Silent_p.L152L|FAM65B_uc011djt.1_Silent_p.L152L	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	152					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						CACCATCCTGGAGGCGTCGCT	0.468													0	0	0	0.000602	0	5	55										C	24865637	G	C	24865637	2	2	54	1	0	0	0	0	0	0	0	1	5600	1161	41	1		1	FAM65B	6	24865637	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7189656	24865637	146249430	368	15146										
FAM65B	9750	broad.mit.edu	37	chr6	24873898	24873898	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccatttttcaaggccctgtaGacttcttccacccttttagg	6	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:24873898G>C	uc003neo.1	-	3	407	c.231C>G	c.(229-231)GTC>GTG	p.V77V	FAM65B_uc011djs.1_Silent_p.V106V|FAM65B_uc011dju.1_Silent_p.V111V|FAM65B_uc003nep.2_Silent_p.V77V|FAM65B_uc011djt.1_Silent_p.V77V	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	77	Involved in cell filopodia formation.				cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AGGCCCTGTAGACTTCTTCCA	0.438													0	0	0	0.001368	0	9	68										C	24873898	G	C	24873898	2	2	54	1	0	0	0	0	0	0	0	1	5600	929	33	1		1	FAM65B	6	24873898	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8261	24873898	146241169	369	15147										
LRRC16A	55604	broad.mit.edu	37	chr6	25466165	25466165	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcacaaaactgtcctctaagGatctaaaactggtaagtaat	6	8	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:25466165G>A	uc011djw.1	+	9	1055	c.679G>A	c.(679-681)GAT>AAT	p.D227N	LRRC16A_uc010jpx.2_Missense_Mutation_p.D227N|LRRC16A_uc010jpy.2_Missense_Mutation_p.D227N|LRRC16A_uc003nez.1_Missense_Mutation_p.D66N	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	227					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GTCCTCTAAGGATCTAAAACT	0.363													0	0	0	0.008871	0	19	171										A	25466165	G	A	25466165	3	1	54	1	0	0	0	0	1	0	0	0	8971	1174	41	1	713	1	LRRC16A	6	25466165	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	592267	25466165	145648902	370	15148										
TRIM38	10475	broad.mit.edu	37	chr6	25967132	25967132	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaaagggcacaccacagctCttgttgaagacgtatgccag	10	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:25967132C>T	uc003nfm.2	+	3	817	c.382C>T	c.(382-384)CTT>TTT	p.L128F	TRIM38_uc003nfn.2_Missense_Mutation_p.L128F	NM_006355	NP_006346	O00635	TRI38_HUMAN	tripartite motif-containing 38	128	B box-type.				positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding				0						CACCACAGCTCTTGTTGAAGA	0.572													0	0	0	0.010504	0	17	132										T	25967132	C	T	25967132	3	4	54	1	0	0	0	0	1	0	0	0	16509	913	32	1	384	1	TRIM38	6	25967132	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	500967	25967132	145147935	371	15149										
HIST1H1C	3006	broad.mit.edu	37	chr6	26056380	26056380	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtgcctttcgtttgcaccaGagtgcccttgctcaccaggc	11	14	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:26056380G>A	uc003nfw.2	-	1	320	c.277C>T	c.(277-279)CTG>TTG	p.L93L		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	93	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GTTTGCACCAGAGTGCCCTTG	0.547													0	0	0	0.010729	0	11	105										A	26056380	G	A	26056380	2	1	54	1	0	0	0	0	0	0	0	1	7124	933	33	1		1	HIST1H1C	6	26056380	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	89248	26056380	145058687	372	15150										
HIST1H2AD	3013	broad.mit.edu	37	chr6	26199108	26199108	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttggccttgtggtgactctCagtcttcttggggagcagta	13	9	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:26199108C>T	uc003ngw.2	-	1	364	c.364G>A	c.(364-366)GAG>AAG	p.E122K	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	122					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				TGGTGACTCTCAGTCTTCTTG	0.488													0	0	0	0.00245	0	11	100										T	26199108	C	T	26199108	3	4	54	1	0	0	0	0	1	0	0	0	7131	835	29	1	32	1	HIST1H2AD	6	26199108	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	142728	26199108	144915959	373	15151										
HIST1H2AD	3013	broad.mit.edu	37	chr6	26199439	26199439	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgggtcttagccttagctcgGgcctttccgccttgcttgcc	11	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:26199439G>A	uc003ngw.2	-	1	33	c.33C>T	c.(31-33)GCC>GCT	p.A11A	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	11					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				CCTTAGCTCGGGCCTTTCCGC	0.527													0	0	0	0.009096	0	4	38										A	26199439	G	A	26199439	2	1	54	1	0	0	0	0	0	0	0	1	7131	1219	43	2		2	HIST1H2AD	6	26199439	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	331	26199439	144915628	374	15152										
BTN3A1	11119	broad.mit.edu	37	chr6	26407997	26407997	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtacccccaaccccaaataCagtggagcaacaacaaggga	9	13	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:26407997C>A	uc003nhv.2	+	4	900	c.532C>A	c.(532-534)CAG>AAG	p.Q178K	BTN3A1_uc011dkj.1_Missense_Mutation_p.Q178K|BTN3A1_uc011dkk.1_Intron|BTN3A1_uc010jqj.2_Missense_Mutation_p.Q178K	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	178	Ig-like V-type 2.|Extracellular (Potential).				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACCCCAAATACAGTGGAGCAA	0.537													1	0	8.58068e-18	0.007291	9.24403e-18	25	119										A	26407997	C	A	26407997	3	1	54	1	0	0	0	0	1	0	0	0	1562	479	17	4	542	4	BTN3A1	6	26407997	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	208558	26407997	144707070	375	15153										
BTN3A1	11119	broad.mit.edu	37	chr6	26411782	26411782	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctgtgtctccttcctttcaGaatggaaaaaggccctcttc	7	12	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:26411782G>A	uc003nhv.2	+	9	1360	c.992_splice	c.e9-1	p.E331_splice	BTN3A1_uc011dkj.1_Splice_Site_p.E331_splice|BTN3A1_uc011dkk.1_Splice_Site_p.E279_splice|BTN3A1_uc010jqj.2_Splice_Site_p.E331_splice	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a						lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CTTCCTTTCAGAATGGAAAAA	0.438													0	0	0	0.004007	0	13	61										A	26411782	G	A	26411782	5	1	54	1	0	0	0	0	0	0	1	0	1562	956	33	1	1021	1	BTN3A1	6	26411782	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3785	26411782	144703285	376	15154										
HIST1H2AM	8336	broad.mit.edu	37	chr6	27860615	27860615	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttaggcagaacaccgccctGagcgatggtaactttaccaa	10	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:27860615G>A	uc003nkb.1	-	1	349	c.313C>T	c.(313-315)CAG>TAG	p.Q105*	HIST1H3J_uc003nka.2_5'Flank|HIST1H2BO_uc003nkc.1_5'Flank	NM_003514	NP_003505	P0C0S8	H2A1_HUMAN	histone cluster 1, H2am	105					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			ovary(2)	2						ACACCGCCCTGAGCGATGGTA	0.542													0	0	0	0.004878	0	35	209										A	27860615	G	A	27860615	4	1	54	1	0	0	0	0	0	1	0	0	7139	1299	45	1	83	1	HIST1H2AM	6	27860615	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1448833	27860615	143254452	377	15155										
ZNF165	7718	broad.mit.edu	37	chr6	28056346	28056346	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttttttattttagataatGagagtgaaaacagtagatcc	7	4	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:28056346G>C	uc003nkg.2	+	5	1640	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	ZNF165_uc003nkh.2_Missense_Mutation_p.E186Q|ZNF165_uc003nki.3_Missense_Mutation_p.E186Q|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	186					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTTAGATAATGAGAGTGAAAA	0.318													0	0	0	0.009096	0	3	30										C	28056346	G	C	28056346	3	2	54	1	0	0	0	0	1	0	0	0	17737	1291	45	1	566	1	ZNF165	6	28056346	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	195731	28056346	143058721	378	15156										
ZNF165	7718	broad.mit.edu	37	chr6	28056916	28056916	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agagatgctatgaatgtaatGaatgtgggaaaagctttgca	12	3	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:28056916G>A	uc003nkg.2	+	5	2210	c.1126G>A	c.(1126-1128)GAA>AAA	p.E376K	ZNF165_uc003nkh.2_Missense_Mutation_p.E376K|ZNF165_uc003nki.3_Missense_Mutation_p.E376K|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	376	C2H2-type 3.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGAATGTAATGAATGTGGGAA	0.443													0	0	0	0.006214	0	6	70										A	28056916	G	A	28056916	3	1	54	1	0	0	0	0	1	0	0	0	17737	1291	45	1	1136	1	ZNF165	6	28056916	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	570	28056916	143058151	379	15157										
MAS1L	116511	broad.mit.edu	37	chr6	29454596	29454596	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagaaggttctccacatgctGagtagagtgtggttgctcca	12	8	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:29454596G>A	uc011dlq.1	-	1	1084	c.1084C>T	c.(1084-1086)CAG>TAG	p.Q362*		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	362	Cytoplasmic (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						TCCACATGCTGAGTAGAGTGT	0.517													0	0	0	0.012319	0	16	100										A	29454596	G	A	29454596	4	1	54	1	0	0	0	0	0	1	0	0	9321	1299	45	1	54	1	MAS1L	6	29454596	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1397680	29454596	141660471	380	15158										
OR2H2	7932	broad.mit.edu	37	chr6	29556417	29556417	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attaactctgcaaaagggcgGaggaaagcttttgggacctg	13	7	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:29556417G>A	uc003nmr.1	+	1	735	c.696G>A	c.(694-696)CGG>CGA	p.R232R	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	232	Cytoplasmic (Potential).			KGR -> TAW (in Ref. 1; AAB36567).	defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAAAAGGGCGGAGGAAAGCTT	0.527													0	0	0	0.001368	0	12	98										A	29556417	G	A	29556417	2	1	54	1	0	0	0	0	0	0	0	1	11002	1161	41	1		1	OR2H2	6	29556417	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	101821	29556417	141558650	381	15159										
RNF39	80352	broad.mit.edu	37	chr6	30043525	30043525	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctcctgggattgcctctctCttcaaccagagtctcagtct	7	14	6	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:30043525C>G	uc003npe.2	-	1	104	c.42G>C	c.(40-42)AAG>AAC	p.K14N	RNF39_uc003npd.2_Missense_Mutation_p.K14N	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	14						cytoplasm	zinc ion binding				0						TTGCCTCTCTCTTCAACCAGA	0.577													0	0	0	0.001368	0	11	117										G	30043525	C	G	30043525	3	3	54	1	0	0	0	0	1	0	0	0	13491	912	32	1	1236	1	RNF39	6	30043525	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	487108	30043525	141071542	382	15160										
TRIM15	89870	broad.mit.edu	37	chr6	30131831	30131831	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggttcctggacgaggccattCagccctaccgggtaagaagt	13	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:30131831C>T	uc010jrx.2	+	1	849	c.370C>T	c.(370-372)CAG>TAG	p.Q124*		NM_033229	NP_150232	Q9C019	TRI15_HUMAN	tripartite motif protein 15	124					mesodermal cell fate determination	intracellular	zinc ion binding				0						CGAGGCCATTCAGCCCTACCG	0.577													0	0	0	0.010504	0	14	96										T	30131831	C	T	30131831	4	4	54	1	0	0	0	0	0	1	0	0	16487	827	29	1	372	1	TRIM15	6	30131831	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	88306	30131831	140983236	383	15161										
GTF2H4	2968	broad.mit.edu	37	chr6	30881724	30881724	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccggccgggcacagcgacgtCaagcgcttttggaagcggca	15	13	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:30881724C>T	uc003nsa.1	+	14	1560	c.1353C>T	c.(1351-1353)GTC>GTT	p.V451V	GTF2H4_uc003nsb.1_Silent_p.V289V|VARS2_uc003nsc.1_5'Flank|VARS2_uc003nsd.2_5'Flank|VARS2_uc011dmx.1_5'Flank|VARS2_uc011dmy.1_5'Flank|VARS2_uc011dmz.1_5'Flank|VARS2_uc011dna.1_5'Flank|VARS2_uc011dnb.1_5'Flank|VARS2_uc011dnc.1_5'Flank	NM_001517	NP_001508	Q92759	TF2H4_HUMAN	general transcription factor IIH, polypeptide 4,	451					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3						ACAGCGACGTCAAGCGCTTTT	0.677								NER					0	0	0	0.004482	0	7	44										T	30881724	C	T	30881724	2	4	54	1	0	0	0	0	0	0	0	1	6865	813	29	1		1	GTF2H4	6	30881724	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	749893	30881724	140233343	384	15162										
CCHCR1	54535	broad.mit.edu	37	chr6	31110790	31110790	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgctacaggtgcagatgctGaacactctggaggcctgggg	15	10	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:31110790G>A	uc003nsr.3	-	17	2297	c.2174C>T	c.(2173-2175)TCA>TTA	p.S725L	CCHCR1_uc011dne.1_Missense_Mutation_p.S711L|CCHCR1_uc003nsq.3_Missense_Mutation_p.S778L|CCHCR1_uc003nsp.3_Missense_Mutation_p.S814L	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	725					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						TGCAGATGCTGAACACTCTGG	0.547													0	0	0	0.00623	0	32	353										A	31110790	G	A	31110790	3	1	54	1	0	0	0	0	1	0	0	0	2877	1294	45	1	182	1	CCHCR1	6	31110790	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	229066	31110790	140004277	385	15163										
C6orf26	401251	broad.mit.edu	37	chr6	31731217	31731217	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggatgcaggctctggagaGagaacaggatgccctgtggc	16	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:31731217G>A	uc003nxa.3	+	2	199	c.140G>A	c.(139-141)AGA>AAA	p.R47K	MSH5_uc003nwz.3_RNA	NM_001039651	NP_001034740	Q5SSQ6	G7D_HUMAN	hypothetical protein LOC401251	47											0						GCTCTGGAGAGAGAACAGGAT	0.592													0	0	0	0.001368	0	10	88										A	31731217	G	A	31731217	3	1	54	1	0	0	0	0	1	0	0	0	2361	942	33	1	146	1	C6orf26	6	31731217	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	620427	31731217	139383850	386	15164										
CYP21A2	1589	broad.mit.edu	37	chr6	32008204	32008204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcagcagcgactgcaggagGagctagaccacgaactgggc	14	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:32008204G>A	uc003nze.1	+	8	1079	c.961G>A	c.(961-963)GAG>AAG	p.E321K	CYP21A2_uc003nzf.1_Missense_Mutation_p.E291K	NM_000500	NP_000491	P08686	CP21A_HUMAN	cytochrome P450, family 21, subfamily A,	320			E -> K (in AH3; simple virilizing form; 4% activity).		glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0						ACTGCAGGAGGAGCTAGACCA	0.662													0	0	0	0.004482	0	7	43										A	32008204	G	A	32008204	3	1	54	1	0	0	0	0	1	0	0	0	4153	1175	41	1	2512	1	CYP21A2	6	32008204	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	276987	32008204	139106863	387	15165										
TNXB	7148	broad.mit.edu	37	chr6	32053680	32053680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcatgtgcccccggcccctCgggcacccgcatgcgcagtt	11	19	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:32053680C>T	uc003nzl.2	-	7	3197	c.2995G>A	c.(2995-2997)GAG>AAG	p.E999K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1086	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCCGGCCCCTCGGGCACCCGC	0.662													0	0	0	0.004878	0	26	185										T	32053680	C	T	32053680	3	4	54	1	0	0	0	0	1	0	0	0	16343	893	31	1	11870	1	TNXB	6	32053680	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	45476	32053680	139061387	388	15166										
AGER	177	broad.mit.edu	37	chr6	32150064	32150064	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcacggctttcctggggcccGtggctggaatgggtggccac	17	12	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:32150064G>A	uc003oal.1	-	8	948	c.924C>T	c.(922-924)CAC>CAT	p.H308H	AGER_uc003oak.1_Silent_p.H37H|AGER_uc003oar.2_Silent_p.H207H|AGER_uc011dpm.1_Silent_p.H207H|AGER_uc011dpn.1_Missense_Mutation_p.T190M|AGER_uc010jtv.1_Intron|AGER_uc011dpo.1_Intron|AGER_uc003oam.1_RNA|AGER_uc003oan.1_Intron|AGER_uc003oap.1_Silent_p.H324H|AGER_uc003oat.1_Silent_p.H324H|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Silent_p.H294H|AGER_uc010jtw.1_Intron|AGER_uc003oas.1_Missense_Mutation_p.T291M|AGER_uc003oau.1_Silent_p.H308H|AGER_uc011dpp.1_Silent_p.H308H	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	308	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						CCTGGGGCCCGTGGCTGGAAT	0.637													0	0	0	0.00361	0	65	98										A	32150064	G	A	32150064	2	1	54	1	0	0	0	0	0	0	0	1	379	1136	40	2		2	AGER	6	32150064	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	96384	32150064	138965003	389	15167										
BRD2	6046	broad.mit.edu	37	chr6	32945290	32945290	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtacggcttatgttctccaaCtgctataagtacaatccccc	6	13	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:32945290C>G	uc003ocn.3	+	8	2973	c.1272C>G	c.(1270-1272)AAC>AAG	p.N424K	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.N424K|BRD2_uc003ocp.3_Missense_Mutation_p.N304K|BRD2_uc010juh.2_Missense_Mutation_p.N424K	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	424	Bromo 2.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						TGTTCTCCAACTGCTATAAGT	0.488													0	0	0	0.005524	0	31	221										G	32945290	C	G	32945290	3	3	54	1	0	0	0	0	1	0	0	0	1502	564	20	4	1298	4	BRD2	6	32945290	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	795226	32945290	138169777	390	15168										
RPS18	6222	broad.mit.edu	37	chr6	33244179	33244179	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacctgcagccttcgtgtccGaggccagcacaccaagacca	9	16	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:33244179G>A	uc003odp.1	+	6	440	c.395G>A	c.(394-396)CGA>CAA	p.R132Q	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	132					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						CTTCGTGTCCGAGGCCAGCAC	0.493													0	0	0	0.001984	0	5	33										A	33244179	G	A	33244179	3	1	54	1	0	0	0	0	1	0	0	0	13628	1058	37	1	417	1	RPS18	6	33244179	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	298889	33244179	137870888	391	15169										
GRM4	2914	broad.mit.edu	37	chr6	34101145	34101145	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgatgtccccatctatgcgGatggaattcatgtgagggtg	14	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:34101145G>A	uc003oir.3	-	1	299	c.129C>T	c.(127-129)ATC>ATT	p.I43I	GRM4_uc011dsn.1_Silent_p.I43I|GRM4_uc010jvh.2_Silent_p.I43I|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_Intron	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	43	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CATCTATGCGGATGGAATTCA	0.617													0	0	0	0.004482	0	5	86										A	34101145	G	A	34101145	2	1	54	1	0	0	0	0	0	0	0	1	6799	1164	41	1		1	GRM4	6	34101145	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	856966	34101145	137013922	392	15170										
SNRPC	6631	broad.mit.edu	37	chr6	34741334	34741334	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cactcggcccggaatgactcGaccagacagataaggataga	11	11	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:34741334G>A	uc003ojt.1	+	6	482	c.467G>A	c.(466-468)CGA>CAA	p.R156Q		NM_003093	NP_003084	P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	156					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1						GGAATGACTCGACCAGACAGA	0.537													0	0	0	0.010729	0	9	115										A	34741334	G	A	34741334	3	1	54	1	0	0	0	0	1	0	0	0	14863	1058	37	1	489	1	SNRPC	6	34741334	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	640189	34741334	136373733	393	15171										
SCUBE3	222663	broad.mit.edu	37	chr6	35216389	35216389	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcccacccccagaactacttCaagtacacagagaaacacaa	5	15	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:35216389C>T	uc003okf.1	+	22	2895	c.2889C>T	c.(2887-2889)TTC>TTT	p.F963F	SCUBE3_uc003okg.1_Silent_p.F962F|SCUBE3_uc003okh.1_Silent_p.F850F	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	963					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AGAACTACTTCAAGTACACAG	0.522													0	0	0	0.007413	0	18	115										T	35216389	C	T	35216389	2	4	54	1	0	0	0	0	0	0	0	1	13946	825	29	1		1	SCUBE3	6	35216389	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	475055	35216389	135898678	394	15172										
SCUBE3	222663	broad.mit.edu	37	chr6	35216431	35216431	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagatgctgccaaaatccttCatcaagctgctccgctccaa	7	14	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:35216431C>A	uc003okf.1	+	22	2937	c.2931C>A	c.(2929-2931)TTC>TTA	p.F977L	SCUBE3_uc003okg.1_Missense_Mutation_p.F976L|SCUBE3_uc003okh.1_Missense_Mutation_p.F864L	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	977					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CAAAATCCTTCATCAAGCTGC	0.493													1	0	1.5739e-10	0.004007	1.66784e-10	16	89										A	35216431	C	A	35216431	3	1	54	1	0	0	0	0	1	0	0	0	13946	825	29	3	3017	3	SCUBE3	6	35216431	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	42	35216431	135898636	395	15173										
C6orf81	221481	broad.mit.edu	37	chr6	35706280	35706280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttctctggcatcagaaaattCaggctcaaaatccaggtgag	9	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:35706280C>T	uc003ola.2	+	3	537	c.510C>T	c.(508-510)TTC>TTT	p.F170F	LOC285847_uc010jvy.1_5'Flank|C6orf81_uc003olb.1_Silent_p.F143F	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	143							binding			ovary(1)	1						TCAGAAAATTCAGGCTCAAAA	0.458													0	0	0	0.001368	0	9	97										T	35706280	C	T	35706280	2	4	54	1	0	0	0	0	0	0	0	1	2372	825	29	1		1	C6orf81	6	35706280	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	489849	35706280	135408787	396	15174										
CDKN1A	1026	broad.mit.edu	37	chr6	36652207	36652208	+	Frame_Shift_Ins	INS	-	-	T													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggacagcagaggaagaccaINStgtggacctgtcactgtctt							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:36652207_36652208insT	uc003omm.3	+	2	451_452	c.329_330insT	c.(328-330)CATfs	p.H110fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.H144fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.H110fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.H110fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	110					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GAGGAAGACCATGTGGACCTGT	0.658									Multiple_Endocrine_Neoplasia_type_1									14	16	---	---								T	36652208	-	T	36652207	7	5	54	1	0	1	1	0	0	0	0	0	3158	217	8	0	331	0	CDKN1A	6	36652207	Frame_Shift_Ins	INS	-	TCGA-DK-A2I4-01A-11D-A21A-08	945927	36652207	134462860	397	15175										
RNF8	9025	broad.mit.edu	37	chr6	37328321	37328321	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgttttgaagcagaatcctGagggccaatggacaattatg	12	6	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:37328321G>A	uc003onq.3	+	2	404	c.211G>A	c.(211-213)GAG>AAG	p.E71K	RNF8_uc003onr.3_Missense_Mutation_p.E71K|RNF8_uc011dtx.1_5'UTR	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	71	FHA.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						GCAGAATCCTGAGGGCCAATG	0.373													0	0	0	0.006214	0	9	62										A	37328321	G	A	37328321	3	1	54	1	0	0	0	0	1	0	0	0	13500	1291	45	1	217	1	RNF8	6	37328321	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	676114	37328321	133786746	398	15176										
FTSJD2	23070	broad.mit.edu	37	chr6	37426534	37426534	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgaagggccctaatgacttCaagctggaggacttctactc	10	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:37426534C>T	uc003ons.2	+	9	1177	c.924C>T	c.(922-924)TTC>TTT	p.F308F	FTSJD2_uc010jwu.2_Silent_p.F252F	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	308					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CTAATGACTTCAAGCTGGAGG	0.522													0	0	0	0.008291	0	9	119										T	37426534	C	T	37426534	2	4	54	1	0	0	0	0	0	0	0	1	6091	825	29	1		1	FTSJD2	6	37426534	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	98213	37426534	133688533	399	15177										
TFEB	7942	broad.mit.edu	37	chr6	41655745	41655745	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcgctgctgtacacattcaGgtggctgctggacaggggta	15	9	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:41655745G>T	uc003oqs.1	-	6	873	c.571C>A	c.(571-573)CTG>ATG	p.L191M	TFEB_uc003oqt.1_Missense_Mutation_p.L191M|TFEB_uc003oqu.1_Missense_Mutation_p.L205M|TFEB_uc003oqv.1_Missense_Mutation_p.L191M|TFEB_uc010jxo.1_Missense_Mutation_p.L191M|TFEB_uc003oqr.1_Missense_Mutation_p.L106M	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	191					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TACACATTCAGGTGGCTGCTG	0.657			T	ALPHA	renal (childhood epithelioid)								1	0	1.06801e-11	0.009535	1.13641e-11	30	153										T	41655745	G	T	41655745	3	4	54	1	0	0	0	0	1	0	0	0	15798	991	35	4	879	4	TFEB	6	41655745	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4229211	41655745	129459322	400	15178										
TAF8	129685	broad.mit.edu	37	chr6	42034150	42034150	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacccgtttcatggccaagaCaggcgagactcagagtcttt	10	11	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:42034150C>G	uc003ors.2	+	6	619	c.590C>G	c.(589-591)ACA>AGA	p.T197R	TAF8_uc003ort.2_Missense_Mutation_p.T197R|TAF8_uc003oru.1_Missense_Mutation_p.T197R|TAF8_uc003orv.1_Missense_Mutation_p.T197R|TAF8_uc011dun.1_Missense_Mutation_p.T134R	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	197					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			ATGGCCAAGACAGGCGAGACT	0.537													0	0	0	0.004007	0	15	80										G	42034150	C	G	42034150	3	3	54	1	0	0	0	0	1	0	0	0	15531	478	17	4	612	4	TAF8	6	42034150	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	378405	42034150	129080917	401	15179										
TRERF1	55809	broad.mit.edu	37	chr6	42236470	42236470	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgcggctgcgtctgtatttCttgcatggagatacgctgtt	12	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:42236470C>G	uc003osd.2	-	5	1422	c.859G>C	c.(859-861)GAA>CAA	p.E287Q	TRERF1_uc011duq.1_Missense_Mutation_p.E287Q|TRERF1_uc003osb.2_Missense_Mutation_p.E126Q|TRERF1_uc003osc.2_Missense_Mutation_p.E126Q|TRERF1_uc003ose.2_Missense_Mutation_p.E287Q	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	287	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GTCTGTATTTCTTGCATGGAG	0.453													0	0	0	0.007835	0	32	223										G	42236470	C	G	42236470	3	3	54	1	0	0	0	0	1	0	0	0	16472	922	32	1	2799	1	TRERF1	6	42236470	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	202320	42236470	128878597	402	15180										
YIPF3	25844	broad.mit.edu	37	chr6	43481347	43481347	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggggaagttgaccatcttGatagggatcatggactccag	14	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:43481347G>C	uc003ovl.1	-	4	577	c.420C>G	c.(418-420)ATC>ATG	p.I140M	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Missense_Mutation_p.I105M|YIPF3_uc010jyr.1_Missense_Mutation_p.I146M|YIPF3_uc010jys.1_Intron|YIPF3_uc003ovm.1_Missense_Mutation_p.I14M|YIPF3_uc010jyt.1_Intron	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	140					cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			TGACCATCTTGATAGGGATCA	0.458													0	0	0	0.009096	0	4	95										C	43481347	G	C	43481347	3	2	54	1	0	0	0	0	1	0	0	0	17476	1280	45	1	656	1	YIPF3	6	43481347	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1244877	43481347	127633720	403	15181										
NFKBIE	4794	broad.mit.edu	37	chr6	44227806	44227806	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtcaggtcctggggcgtctCatcctccacattccgcagca	10	15	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:44227806C>T	uc003oxe.1	-	5	1436	c.1411G>A	c.(1411-1413)GAG>AAG	p.E471K	SLC35B2_uc003oxd.2_5'Flank|SLC35B2_uc011dvt.1_5'Flank|SLC35B2_uc011dvu.1_5'Flank	NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	471					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGGGGCGTCTCATCCTCCACA	0.567													0	0	0	0.008871	0	16	103										T	44227806	C	T	44227806	3	4	54	1	0	0	0	0	1	0	0	0	10380	835	29	1	99	1	NFKBIE	6	44227806	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	746459	44227806	126887261	404	15182										
GPR116	221395	broad.mit.edu	37	chr6	46851331	46851331	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtcttgtaggacctatagaGggcggaggaagtgttcatga	16	5	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:46851331G>A	uc003oyo.3	-	6	866	c.577C>T	c.(577-579)CTC>TTC	p.L193F	GPR116_uc003oyp.3_Missense_Mutation_p.L193F|GPR116_uc003oyq.3_Missense_Mutation_p.L193F|GPR116_uc003oyr.2_Missense_Mutation_p.L193F	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	193	SEA.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			GACCTATAGAGGGCGGAGGAA	0.428													0	0	0	0.00308	0	6	36										A	46851331	G	A	46851331	3	1	54	1	0	0	0	0	1	0	0	0	6633	1000	35	2	3527	2	GPR116	6	46851331	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2623525	46851331	124263736	405	15183										
TFAP2B	7021	broad.mit.edu	37	chr6	50805697	50805697	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcaatttcagagccaaatcGaaaaatggggggagatcttt	11	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:50805697G>A	uc003pag.2	+	5	997	c.831G>A	c.(829-831)TCG>TCA	p.S277S		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	277					nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					GAGCCAAATCGAAAAATGGGG	0.433													0	0	0	0.00308	0	7	85										A	50805697	G	A	50805697	2	1	54	1	0	0	0	0	0	0	0	1	15785	1045	37	1		1	TFAP2B	6	50805697	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3954366	50805697	120309370	406	15184										
DST	667	broad.mit.edu	37	chr6	56464987	56464987	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcacatatcccttggagtttCtctttatactcctgctgacg	6	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:56464987C>G	uc003pdf.2	-	39	5245	c.5217G>C	c.(5215-5217)GAG>GAC	p.E1739D	DST_uc003pcz.3_Missense_Mutation_p.E1561D|DST_uc011dxj.1_Missense_Mutation_p.E1590D|DST_uc011dxk.1_Missense_Mutation_p.E1601D|DST_uc003pcy.3_Missense_Mutation_p.E1235D|DST_uc010kaa.1_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3647					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTTGGAGTTTCTCTTTATACT	0.403													0	0	0	0.00308	0	8	22										G	56464987	C	G	56464987	3	3	54	1	0	0	0	0	1	0	0	0	4783	912	32	1	12046	1	DST	6	56464987	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5659290	56464987	114650080	407	15185										
DST	667	broad.mit.edu	37	chr6	56479189	56479189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggaggttttccagccttctCtgcatctttcaatgtcttgc	9	11	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:56479189C>G	uc003pdf.2	-	36	4952	c.4924G>C	c.(4924-4926)GAG>CAG	p.E1642Q	DST_uc003pcz.3_Missense_Mutation_p.E1464Q|DST_uc011dxj.1_Missense_Mutation_p.E1493Q|DST_uc011dxk.1_Missense_Mutation_p.E1504Q|DST_uc003pcy.3_Missense_Mutation_p.E1138Q|DST_uc003pdb.2_Missense_Mutation_p.E1138Q	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3540					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCAGCCTTCTCTGCATCTTTC	0.373													0	0	0	0.009096	0	4	13										G	56479189	C	G	56479189	3	3	54	1	0	0	0	0	1	0	0	0	4783	922	32	1	12351	1	DST	6	56479189	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	14202	56479189	114635878	408	15186										
KCNQ5	56479	broad.mit.edu	37	chr6	73843259	73843259	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caagcaccgacatcacagccGagggcagtcccaccaaagtg	10	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:73843259G>T	uc003pgk.2	+	10	1710	c.1363G>T	c.(1363-1365)GAG>TAG	p.E455*	KCNQ5_uc011dyh.1_Nonsense_Mutation_p.E474*|KCNQ5_uc011dyi.1_Nonsense_Mutation_p.E465*|KCNQ5_uc010kat.2_Nonsense_Mutation_p.E446*|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Nonsense_Mutation_p.E205*	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	455					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CATCACAGCCGAGGGCAGTCC	0.592													1	0	0.00621372	0.006214	0.00633594	9	106										T	73843259	G	T	73843259	4	4	54	1	0	0	0	0	0	1	0	0	8086	1059	37	3	1462	3	KCNQ5	6	73843259	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	17364070	73843259	97271808	409	15187										
DOPEY1	23033	broad.mit.edu	37	chr6	83841961	83841961	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcatcaccagaagagtgtgGaactattttatcaattacat	7	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:83841961G>C	uc003pjs.1	+	18	2943	c.2683G>C	c.(2683-2685)GAA>CAA	p.E895Q	DOPEY1_uc011dyy.1_Missense_Mutation_p.E886Q|DOPEY1_uc010kbl.1_Missense_Mutation_p.E886Q	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	895					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GAAGAGTGTGGAACTATTTTA	0.368													0	0	0	0.008291	0	9	57										C	83841961	G	C	83841961	3	2	54	1	0	0	0	0	1	0	0	0	4707	1175	41	1	2745	1	DOPEY1	6	83841961	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9998702	83841961	87273106	410	15188										
SNX14	57231	broad.mit.edu	37	chr6	86256945	86256945	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcaattctaacttcagcacCttgatataagagaaagatta	5	7	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:86256945C>G	uc003pkr.2	-	12	1187	c.994_splice	c.e12-1	p.V332_splice	SNX14_uc003pkp.2_Splice_Site_p.V195_splice|SNX14_uc003pkq.2_Splice_Site|SNX14_uc011dzg.1_Splice_Site_p.V280_splice|SNX14_uc003pks.2_Splice_Site_p.V288_splice|SNX14_uc003pkt.2_Splice_Site_p.V332_splice	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a						cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ACTTCAGCACCTTGATATAAG	0.318													0	0	0	0.004672	0	3	18										G	86256945	C	G	86256945	5	3	54	1	0	0	0	0	0	0	1	0	14885	695	24	4	1919	4	SNX14	6	86256945	Splice_Site	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2414984	86256945	84858122	411	15189										
ZNF292	23036	broad.mit.edu	37	chr6	87969858	87969858	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaactaaacaaactttgaaaGaatttcgatgtcaggtaagt	7	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:87969858G>C	uc003plm.3	+	8	6552	c.6511G>C	c.(6511-6513)GAA>CAA	p.E2171Q		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AACTTTGAAAGAATTTCGATG	0.368													0	0	0	0.001168	0	5	38										C	87969858	G	C	87969858	3	2	54	1	0	0	0	0	1	0	0	0	17823	943	33	1	6541	1	ZNF292	6	87969858	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1712913	87969858	83145209	412	15190										
NR2E1	7101	broad.mit.edu	37	chr6	108496093	108496093	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagtgcagggcgtgtcggctGaagaagtgtttggaagtcaa	16	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:108496093G>A	uc003psg.2	+	3	980	c.225G>A	c.(223-225)CTG>CTA	p.L75L		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	75	Nuclear receptor.|NR C4-type.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		CGTGTCGGCTGAAGAAGTGTT	0.483													0	0	0	0.00333	0	18	86										A	108496093	G	A	108496093	2	1	54	1	0	0	0	0	0	0	0	1	10625	1277	45	1		1	NR2E1	6	108496093	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	20526235	108496093	62618974	413	15191										
LAMA4	3910	broad.mit.edu	37	chr6	112476811	112476811	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caaagcaaattctgctgtttCattggcttcactaacataat	5	9	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:112476811C>T	uc003pvu.2	-	15	2224	c.1915G>A	c.(1915-1917)GAA>AAA	p.E639K	LAMA4_uc003pvv.2_Missense_Mutation_p.E632K|LAMA4_uc003pvt.2_Missense_Mutation_p.E632K	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	639	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TCTGCTGTTTCATTGGCTTCA	0.388													0	0	0	0.002299	0	18	91										T	112476811	C	T	112476811	3	4	54	1	0	0	0	0	1	0	0	0	8608	835	29	1	3656	1	LAMA4	6	112476811	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3980718	112476811	58638256	414	15192										
HDAC2	3066	broad.mit.edu	37	chr6	114274470	114274470	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctgtgccaggaaagtattCcccatatttatggaatgata	8	8	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:114274470C>T	uc003pwd.1	-	6	892	c.892G>A	c.(892-894)GAA>AAA	p.E298K	HDAC2_uc003pwc.1_Missense_Mutation_p.E174K|HDAC2_uc003pwe.1_Missense_Mutation_p.E174K	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	204	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	GGAAAGTATTCCCCATATTTA	0.348													0	0	0	0.008871	0	17	120										T	114274470	C	T	114274470	3	4	54	1	0	0	0	0	1	0	0	0	7007	864	30	1	892	1	HDAC2	6	114274470	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1797659	114274470	56840597	415	15193										
RFX6	222546	broad.mit.edu	37	chr6	117245835	117245835	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccatccataaacaaggttCttttcatttgattcgaatgc	5	10	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:117245835C>G	uc003pxm.2	+	15	1622	c.1559C>G	c.(1558-1560)TCT>TGT	p.S520C		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	520					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						AAACAAGGTTCTTTTCATTTG	0.393													0	0	0	0.001168	0	5	48										G	117245835	C	G	117245835	3	3	54	1	0	0	0	0	1	0	0	0	13267	913	32	1	1617	1	RFX6	6	117245835	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2971365	117245835	53869232	416	15194										
PTPRK	5796	broad.mit.edu	37	chr6	128410865	128410865	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtttgaataattgtctcttCactctccttccttccctctg	4	13	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:128410865C>A	uc003qbk.2	-	8	1802	c.1435G>T	c.(1435-1437)GAA>TAA	p.E479*	PTPRK_uc003qbj.2_Nonsense_Mutation_p.E479*|PTPRK_uc010kfc.2_Nonsense_Mutation_p.E479*|PTPRK_uc011ebu.1_Nonsense_Mutation_p.E479*|PTPRK_uc003qbl.1_Nonsense_Mutation_p.E349*|PTPRK_uc011ebv.1_Nonsense_Mutation_p.E479*	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	479	Extracellular (Potential).|Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATTGTCTCTTCACTCTCCTTC	0.408													1	0	0.000151284	0.001855	0.000155607	10	104										A	128410865	C	A	128410865	4	1	54	1	0	0	0	0	0	1	0	0	12805	835	29	3	3001	3	PTPRK	6	128410865	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11165030	128410865	42704202	417	15195										
PTPRK	5796	broad.mit.edu	37	chr6	128505838	128505838	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atatgtaggcccaacaccaaGaagctgaggaggagcaatgg	13	8	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:128505838G>A	uc003qbk.2	-	7	1268	c.901C>T	c.(901-903)CTT>TTT	p.L301F	PTPRK_uc003qbj.2_Missense_Mutation_p.L301F|PTPRK_uc010kfc.2_Missense_Mutation_p.L301F|PTPRK_uc011ebu.1_Missense_Mutation_p.L301F|PTPRK_uc003qbl.1_Missense_Mutation_p.L171F|PTPRK_uc011ebv.1_Missense_Mutation_p.L301F	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	301	Fibronectin type-III 1.|Extracellular (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CCAACACCAAGAAGCTGAGGA	0.408													0	0	0	0.003163	0	11	23										A	128505838	G	A	128505838	3	1	54	1	0	0	0	0	1	0	0	0	12805	942	33	1	3539	1	PTPRK	6	128505838	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	94973	128505838	42609229	418	15196										
CTGF	1490	broad.mit.edu	37	chr6	132271489	132271489	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcgtcacacacccactcctCgcagcatttcccgggcagct	7	19	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:132271489C>T	uc003qcz.2	-	3	690	c.484G>A	c.(484-486)GAG>AAG	p.E162K		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	162	VWFC.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		ACCCACTCCTCGCAGCATTTC	0.652											OREG0017666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	35	213										T	132271489	C	T	132271489	3	4	54	1	0	0	0	0	1	0	0	0	4008	893	31	1	577	1	CTGF	6	132271489	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3765651	132271489	38843578	419	15197										
TAAR8	83551	broad.mit.edu	37	chr6	132874133	132874133	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagctgctggtattttggagCcaaattttgtactcttcaca	9	8	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:132874133C>T	uc011ecj.1	+	1	302	c.302C>T	c.(301-303)GCC>GTC	p.A101V		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	101	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		TATTTTGGAGCCAAATTTTGT	0.468													0	0	0	0.004482	0	9	55										T	132874133	C	T	132874133	3	4	54	1	0	0	0	0	1	0	0	0	15490	739	26	2	304	2	TAAR8	6	132874133	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	602644	132874133	38240934	420	15198										
CCDC28A	25901	broad.mit.edu	37	chr6	139101069	139101069	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agatgttcaggagatggagaGagggctgctcagtcttttga	15	5	3	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:139101069G>C	uc003qie.2	+	3	694	c.539G>C	c.(538-540)AGA>ACA	p.R180T		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	180											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		GAGATGGAGAGAGGGCTGCTC	0.443													0	0	0	0.006122	0	12	60										C	139101069	G	C	139101069	3	2	54	1	0	0	0	0	1	0	0	0	2802	942	33	1	549	1	CCDC28A	6	139101069	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6226936	139101069	32013998	421	15199										
ECT2L	345930	broad.mit.edu	37	chr6	139186275	139186275	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggaagcagctgtatcctttCttcaaggaactgcagaagag	11	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:139186275C>T	uc003qif.1	+	10	1537	c.1434C>T	c.(1432-1434)TTC>TTT	p.F478F	ECT2L_uc011edq.1_Silent_p.F409F	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	478					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TGTATCCTTTCTTCAAGGAAC	0.443													0	0	0	0.000602	0	3	38										T	139186275	C	T	139186275	2	4	54	1	0	0	0	0	0	0	0	1	4902	912	32	1		1	ECT2L	6	139186275	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	85206	139186275	31928792	422	15200										
TXLNB	167838	broad.mit.edu	37	chr6	139564283	139564283	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atccacagagacgtttgactCtggctcttcatcggagttgt	10	10	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:139564283C>G	uc011eds.1	-	10	1600	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	479						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		ACGTTTGACTCTGGCTCTTCA	0.433													0	0	0	0.008871	0	14	78										G	139564283	C	G	139564283	3	3	54	1	0	0	0	0	1	0	0	0	16785	922	32	1	623	1	TXLNB	6	139564283	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	378008	139564283	31550784	423	15201										
UTRN	7402	broad.mit.edu	37	chr6	144858794	144858794	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctgttggttaacaaaggctGagcatgctatgcaaaagaga	11	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:144858794G>A	uc003qkt.2	+	43	6402	c.6310G>A	c.(6310-6312)GAG>AAG	p.E2104K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2104					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AACAAAGGCTGAGCATGCTAT	0.368													0	0	0	0.001168	0	4	42										A	144858794	G	A	144858794	3	1	54	1	0	0	0	0	1	0	0	0	17100	1291	45	1	6480	1	UTRN	6	144858794	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5294511	144858794	26256273	424	15202										
FBXO30	84085	broad.mit.edu	37	chr6	146127160	146127160	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttctaagagcatcctttggtCttgaagagccaaggccatat	9	9	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:146127160C>G	uc003qla.2	-	2	581	c.382G>C	c.(382-384)GAC>CAC	p.D128H	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	128							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		ATCCTTTGGTCTTGAAGAGCC	0.408													0	0	0	0.004482	0	8	33										G	146127160	C	G	146127160	3	3	54	1	0	0	0	0	1	0	0	0	5740	913	32	1	1863	1	FBXO30	6	146127160	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1268366	146127160	24987907	425	15203										
SYNE1	23345	broad.mit.edu	37	chr6	152651320	152651320	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcaagatgtatggttactcGtttcagtacaatccctgagt	8	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:152651320G>A	uc010kiw.2	-	78	15102	c.14500C>T	c.(14500-14502)CGA>TGA	p.R4834*	SYNE1_uc003qot.3_Nonsense_Mutation_p.R4763*|SYNE1_uc003qou.3_Nonsense_Mutation_p.R4834*|SYNE1_uc010kiz.2_Nonsense_Mutation_p.R589*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4834	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGGTTACTCGTTTCAGTACA	0.498										HNSCC(10;0.0054)			0	0	0	0.001368	0	9	39										A	152651320	G	A	152651320	4	1	54	1	0	0	0	0	0	1	0	0	15442	1153	40	2	12242	2	SYNE1	6	152651320	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6524160	152651320	18463747	426	15204										
SYNE1	23345	broad.mit.edu	37	chr6	152651534	152651534	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctctgttctgtttgtcgcttCagcctgtgatataaggtgac	10	9	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:152651534C>T	uc010kiw.2	-	78	14888	c.14286G>A	c.(14284-14286)CTG>CTA	p.L4762L	SYNE1_uc003qot.3_Silent_p.L4691L|SYNE1_uc003qou.3_Silent_p.L4762L|SYNE1_uc010kiz.2_Silent_p.L517L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4762	Spectrin 14.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTTGTCGCTTCAGCCTGTGAT	0.483										HNSCC(10;0.0054)			0	0	0	0.009096	0	4	61										T	152651534	C	T	152651534	2	4	54	1	0	0	0	0	0	0	0	1	15442	813	29	1		1	SYNE1	6	152651534	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	214	152651534	18463533	427	15205										
EZR	7430	broad.mit.edu	37	chr6	159210405	159210406	+	Splice_Site	INS	-	-	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtaactcggacattgatctINSgaaaaacagaatgaaacaaa							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:159210405_159210406insA	uc003qrt.3	-	2	228	c.13_splice	c.e2-1	p.I5_splice	EZR_uc011efs.1_Splice_Site_p.I5_splice|EZR_uc003qru.3_Splice_Site_p.I5_splice	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin						actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GACATTGATCTGAAAAACAGAA	0.426																		8	40	---	---								A	159210406	-	A	159210405	8	5	54	1	0	1	1	0	0	0	1	0	5335	1594	55	0	1797	0	EZR	6	159210405	Splice_Site	INS	-	TCGA-DK-A2I4-01A-11D-A21A-08	6558871	159210405	11904662	428	15206										
IGF2R	3482	broad.mit.edu	37	chr6	160477479	160477479	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agccaccccatcttttctctCaactgggagtgtgtggtcag	10	12	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:160477479C>G	uc003qta.2	+	20	2866	c.2718C>G	c.(2716-2718)CTC>CTG	p.L906L		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	906	6.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TCTTTTCTCTCAACTGGGAGT	0.488													0	0	0	0.012319	0	19	137										G	160477479	C	G	160477479	2	3	54	1	0	0	0	0	0	0	0	1	7576	813	29	1		1	IGF2R	6	160477479	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1267074	160477479	10637588	429	15207										
IGF2R	3482	broad.mit.edu	37	chr6	160479137	160479137	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaaggatataacgtctctgGcattgggaagatttttatgg	12	5	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:160479137G>C	uc003qta.2	+	21	3027	c.2879G>C	c.(2878-2880)GGC>GCC	p.G960A		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	960	7.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AACGTCTCTGGCATTGGGAAG	0.418													0	0	0	0.001368	0	10	68										C	160479137	G	C	160479137	3	2	54	1	0	0	0	0	1	0	0	0	7576	1203	42	4	2961	4	IGF2R	6	160479137	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1658	160479137	10635930	430	15208										
T	6862	broad.mit.edu	37	chr6	166580899	166580899	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttcttggtcacgatcatctCattggtgagctccttgaagc	10	10	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr6:166580899C>G	uc003quu.1	-	2	674	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	T_uc003qut.1_Missense_Mutation_p.E61Q|T_uc003quv.1_Missense_Mutation_p.E61Q	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	61	T-box.				anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		ACGATCATCTCATTGGTGAGC	0.701									Chordoma_Familial_Clustering_of				0	0	0	0.010729	0	8	77										G	166580899	C	G	166580899	3	3	54	1	0	0	0	0	1	0	0	0	15485	835	29	1	1158	1	T	6	166580899	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6101762	166580899	4534168	431	15209										
ZFAND2A	90637	broad.mit.edu	37	chr7	1197336	1197336	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgtgcagcgtatggaaaatGatctttacagaaatcttgtt	9	5	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:1197336G>T	uc003skc.2	-	3	407	c.106C>A	c.(106-108)CAT>AAT	p.H36N	ZFAND2A_uc003skd.3_Missense_Mutation_p.H36N|uc003skf.1_5'Flank	NM_182491	NP_872297	Q8N6M9	ZFN2A_HUMAN	zinc finger, AN1-type domain 2A	36	AN1-type 1.					cytoplasm|nucleus	zinc ion binding			ovary(1)	1		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.82e-15)		TATGGAAAATGATCTTTACAG	0.328													1	0	1.55811e-20	0.008361	1.68276e-20	25	276										T	1197336	G	T	1197336	3	4	54	1	0	0	0	0	1	0	0	0	17624	1290	45	3	343	3	ZFAND2A	7	1197336	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		1197336	157941327	432	15210										
INTS1	26173	broad.mit.edu	37	chr7	1515921	1515921	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccgtcaccttcctgacactCtcatcgtccccacagcagca	5	19	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:1515921C>G	uc003skn.2	-	38	5423	c.5322G>C	c.(5320-5322)GAG>GAC	p.E1774D	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1774					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		TCCTGACACTCTCATCGTCCC	0.692													0	0	0	0.001984	0	5	23										G	1515921	C	G	1515921	3	3	54	1	0	0	0	0	1	0	0	0	7775	912	32	1	1294	1	INTS1	7	1515921	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	318585	1515921	157622742	433	15211										
INTS1	26173	broad.mit.edu	37	chr7	1521036	1521036	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggccactgcctggtccagGaactggaggagtttgctcat	14	10	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:1521036G>A	uc003skn.2	-	28	3893	c.3792C>T	c.(3790-3792)TTC>TTT	p.F1264F		NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1264					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CCTGGTCCAGGAACTGGAGGA	0.612													0	0	0	0.00308	0	7	107										A	1521036	G	A	1521036	2	1	54	1	0	0	0	0	0	0	0	1	7775	1165	41	1		1	INTS1	7	1521036	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5115	1521036	157617627	434	15212										
ACTB	60	broad.mit.edu	37	chr7	5569265	5569265	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccggagccgttgtcgacgacGagcgcggcgatatcatcatc	13	13	2	0	rs151181948		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:5569265G>T	uc003sos.3	-	1	60	c.24C>A	c.(22-24)CTC>CTA	p.L8L	ACTB_uc003sor.3_5'Flank|ACTB_uc003sot.3_Silent_p.L8L|ACTB_uc003soq.3_5'UTR|ACTB_uc010ksy.2_Intron|ACTB_uc011jwi.1_5'Flank	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	8					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGTCGACGACGAGCGCGGCGA	0.721													1	0	1.75199e-13	0.007291	1.87032e-13	20	125										T	5569265	G	T	5569265	2	4	54	1	0	0	0	0	0	0	0	1	193	1045	37	3		3	ACTB	7	5569265	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4048229	5569265	153569398	435	15213										
FSCN1	6624	broad.mit.edu	37	chr7	5633134	5633134	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaccagcgctacagcgtgcaGaccgccgaccaccgcttcct	10	18	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:5633134G>C	uc003sou.2	+	1	681	c.567G>C	c.(565-567)CAG>CAC	p.Q189H		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	189					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		ACAGCGTGCAGACCGCCGACC	0.741													0	0	0	0.001984	0	5	59										C	5633134	G	C	5633134	3	2	54	1	0	0	0	0	1	0	0	0	6067	933	33	1	569	1	FSCN1	7	5633134	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	63869	5633134	153505529	436	15214										
C7orf28A	51622	broad.mit.edu	37	chr7	5949692	5949692	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attagaacaagatgacatgaGaattttatacaaatacctta	5	5	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:5949692G>C	uc003spf.2	+	8	815	c.725G>C	c.(724-726)AGA>ACA	p.R242T		NM_015622	NP_056437	P86791	CCZ1_HUMAN	hypothetical protein LOC51622	242						lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)		GATGACATGAGAATTTTATAC	0.438													0	0	0	0.010729	0	8	32										C	5949692	G	C	5949692	3	2	54	1	0	0	0	0	1	0	0	0	2383	942	33	1	755	1	C7orf28A	7	5949692	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	316558	5949692	153188971	437	15215										
USP42	84132	broad.mit.edu	37	chr7	6189333	6189333	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttaatgcttcagcttctgtCcaaaactggtcagttaatag	8	8	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:6189333C>T	uc011jwo.1	+	13	1629	c.1506C>T	c.(1504-1506)GTC>GTT	p.V502V	USP42_uc010kth.1_Silent_p.V435V|USP42_uc011jwp.1_Silent_p.V502V|USP42_uc011jwq.1_Silent_p.V309V|USP42_uc011jwr.1_Silent_p.V347V	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	502					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		CAGCTTCTGTCCAAAACTGGT	0.453													0	0	0	0.008291	0	10	113										T	6189333	C	T	6189333	2	4	54	1	0	0	0	0	0	0	0	1	17070	842	30	1		1	USP42	7	6189333	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	239641	6189333	152949330	438	15216										
ZDHHC4	55146	broad.mit.edu	37	chr7	6624735	6624735	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaacatcaggtacttcctCatctacgtcttgaccttgac	7	12	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:6624735C>A	uc003sqi.2	+	8	943	c.585C>A	c.(583-585)CTC>CTA	p.L195L	ZDHHC4_uc003sql.2_Silent_p.L195L|ZDHHC4_uc003sqh.2_Silent_p.L195L|ZDHHC4_uc003sqj.2_Silent_p.L195L|ZDHHC4_uc003sqk.2_Silent_p.L195L|ZDHHC4_uc003sqm.2_Silent_p.L195L	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	195	DHHC-type.|Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		GGTACTTCCTCATCTACGTCT	0.527													1	0	2.44723e-14	0.004656	2.61684e-14	20	81										A	6624735	C	A	6624735	2	1	54	1	0	0	0	0	0	0	0	1	17614	813	29	3		3	ZDHHC4	7	6624735	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	435402	6624735	152513928	439	15217										
ZNF12	7559	broad.mit.edu	37	chr7	6730899	6730899	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgaggtatgacatctgagaGaagaattttccacatatata	9	5	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:6730899G>A	uc003sqt.1	-	5	2228	c.1674C>T	c.(1672-1674)TTC>TTT	p.F558F	ZNF12_uc011jxa.1_Silent_p.F396F|ZNF12_uc003sqs.1_Silent_p.F520F	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	558	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		ACATCTGAGAGAAGAATTTTC	0.413													0	0	0	0.004672	0	3	28										A	6730899	G	A	6730899	2	1	54	1	0	0	0	0	0	0	0	1	17715	933	33	1		1	ZNF12	7	6730899	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	106164	6730899	152407764	440	15218										
ZNF12	7559	broad.mit.edu	37	chr7	6732258	6732258	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttcaatcagggtctcaatGaacacagtttgccttgaagg	9	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:6732258G>A	uc003sqt.1	-	5	869	c.315C>T	c.(313-315)TTC>TTT	p.F105F	ZNF12_uc011jxa.1_5'UTR|ZNF12_uc003sqs.1_Silent_p.F105F	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	105					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GGGTCTCAATGAACACAGTTT	0.363													0	0	0	0.006122	0	16	125										A	6732258	G	A	6732258	2	1	54	1	0	0	0	0	0	0	0	1	17715	1281	45	1		1	ZNF12	7	6732258	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1359	6732258	152406405	441	15219										
C7orf28B	221960	broad.mit.edu	37	chr7	6854450	6854450	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taaggtatttgtataaaattCtcatgtcatcttgttctaat	5	5	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:6854450C>G	uc003sqx.1	-	8	758	c.725G>C	c.(724-726)AGA>ACA	p.R242T	C7orf28B_uc011jxd.1_Missense_Mutation_p.R99T	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960	242						lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		GTATAAAATTCTCATGTCATC	0.438													0	0	0	0.002299	0	17	201										G	6854450	C	G	6854450	3	3	54	1	0	0	0	0	1	0	0	0	2384	913	32	1	755	1	C7orf28B	7	6854450	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	122192	6854450	152284213	442	15220										
ICA1	3382	broad.mit.edu	37	chr7	8198207	8198207	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attgcatctgctcgctccaaGaagatccactttttgacaaa	6	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:8198207G>A	uc003srm.2	-	7	722	c.655C>T	c.(655-657)CTT>TTT	p.L219F	ICA1_uc010ktr.2_Missense_Mutation_p.L219F|ICA1_uc003srl.2_Missense_Mutation_p.L207F|ICA1_uc003srn.3_Missense_Mutation_p.L145F|ICA1_uc003srp.3_Missense_Mutation_p.L218F|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.L219F|ICA1_uc003srr.2_Missense_Mutation_p.L218F|ICA1_uc003sro.3_Missense_Mutation_p.L219F|ICA1_uc011jxg.1_Missense_Mutation_p.L219F|ICA1_uc003srs.1_Missense_Mutation_p.L219F	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	219	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CTCGCTCCAAGAAGATCCACT	0.373													0	0	0	0.009096	0	4	58										A	8198207	G	A	8198207	3	1	54	1	0	0	0	0	1	0	0	0	7477	942	33	1	828	1	ICA1	7	8198207	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1343757	8198207	150940456	443	15221										
IL6	3569	broad.mit.edu	37	chr7	22771127	22771127	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctgcaggacatgacaactCatctcattctgcgcagcttt	9	12	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:22771127C>T	uc011jyn.1	+	6	1033	c.574C>T	c.(574-576)CAT>TAT	p.H192Y	IL6_uc003svj.3_Missense_Mutation_p.H192Y	NM_000600	NP_000591	P05231	IL6_HUMAN	interleukin 6 precursor	192					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding				0					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	CATGACAACTCATCTCATTCT	0.512													0	0	0	0.000602	0	5	50										T	22771127	C	T	22771127	3	4	54	1	0	0	0	0	1	0	0	0	7701	826	29	1	592	1	IL6	7	22771127	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	14572920	22771127	136367536	444	15222										
TAX1BP1	8887	broad.mit.edu	37	chr7	27856100	27856100	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtcaaatgcacaaccagttCtgcaatatggtaatccttat	6	9	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:27856100C>G	uc003szl.2	+	14	2055	c.1897C>G	c.(1897-1899)CTG>GTG	p.L633V	TAX1BP1_uc011jzo.1_Intron|TAX1BP1_uc003szk.2_Intron|TAX1BP1_uc011jzp.1_Intron	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	633					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			ACAACCAGTTCTGCAATATGG	0.363													0	0	0	0.00333	0	20	91										G	27856100	C	G	27856100	3	3	54	1	0	0	0	0	1	0	0	0	15591	912	32	1	1947	1	TAX1BP1	7	27856100	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5084973	27856100	131282563	445	15223										
TRIL	9865	broad.mit.edu	37	chr7	28996953	28996953	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtgctgcaggttgttggccGagaggatgagggaggagagg	22	4	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:28996953G>A	uc003szt.2	-	3	1077	c.710C>T	c.(709-711)TCG>TTG	p.S237L	uc003szu.1_5'Flank	NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	237	Extracellular (Potential).|LRR 8.				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0						GTTGTTGGCCGAGAGGATGAG	0.677													0	0	0	0.006122	0	17	148										A	28996953	G	A	28996953	3	1	54	1	0	0	0	0	1	0	0	0	16482	1059	37	1	1729	1	TRIL	7	28996953	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1140853	28996953	130141710	446	15224										
NOD1	10392	broad.mit.edu	37	chr7	30492526	30492526	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgcccaggctctcattgctGaagccaaccagctccatgat	8	15	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:30492526G>A	uc003tav.2	-	6	1030	c.507C>T	c.(505-507)TTC>TTT	p.F169F	NOD1_uc010kvs.2_Silent_p.F169F	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	169					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						TCTCATTGCTGAAGCCAACCA	0.587													0	0	0	0.002299	0	18	169										A	30492526	G	A	30492526	2	1	54	1	0	0	0	0	0	0	0	1	10516	1281	45	1		1	NOD1	7	30492526	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1495573	30492526	128646137	447	15225										
BBS9	27241	broad.mit.edu	37	chr7	33392470	33392470	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcattgcctgtgatggacaGatcgaaatcctgatggtaag	12	7	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:33392470G>C	uc003tdn.1	+	15	2051	c.1538_splice	c.e15-1	p.D513_splice	BBS9_uc003tdo.1_Splice_Site_p.N478_splice|BBS9_uc003tdp.1_Intron|BBS9_uc003tdq.1_Intron|BBS9_uc010kwn.1_Splice_Site|BBS9_uc003tdr.1_Splice_Site_p.D37_splice|BBS9_uc003tds.1_Splice_Site|BBS9_uc011kao.1_Splice_Site_p.D391_splice	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2						fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTGATGGACAGATCGAAATCC	0.323									Bardet-Biedl_syndrome				0	0	0	0.001855	0	11	48										C	33392470	G	C	33392470	5	2	54	1	0	0	0	0	0	0	1	0	1342	956	33	1	1591	1	BBS9	7	33392470	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2899944	33392470	125746193	448	15226										
HERPUD2	64224	broad.mit.edu	37	chr7	35674914	35674914	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctccctgtgcattcatttGaacattctcattcatgggtc	6	12	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:35674914G>C	uc003tet.2	-	6	1577	c.772C>G	c.(772-774)CAA>GAA	p.Q258E	HERPUD2_uc003tes.3_Missense_Mutation_p.Q258E	NM_022373	NP_071768	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	258					response to unfolded protein	integral to membrane				ovary(3)	3						GCATTCATTTGAACATTCTCA	0.468													0	0	0	0.005443	0	24	170										C	35674914	G	C	35674914	3	2	54	1	0	0	0	0	1	0	0	0	7064	1299	45	1	460	1	HERPUD2	7	35674914	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2282444	35674914	123463749	449	15227										
GCK	2645	broad.mit.edu	37	chr7	44193018	44193018	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atccgtctcatcaccttcttCaggtcctcctcctgcagctg	6	17	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:44193018C>T	uc003tkl.2	-	2	560	c.90G>A	c.(88-90)CTG>CTA	p.L30L	GCK_uc003tkj.1_Silent_p.L29L|GCK_uc003tkk.1_Silent_p.L31L	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	30					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TCACCTTCTTCAGGTCCTCCT	0.632													0	0	0	0.00361	0	54	480										T	44193018	C	T	44193018	2	4	54	1	0	0	0	0	0	0	0	1	6293	813	29	1		1	GCK	7	44193018	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	8518104	44193018	114945645	450	15228										
CAMK2B	816	broad.mit.edu	37	chr7	44259671	44259671	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acactcaccttcactgcagcGgggccacaggcgcgcccgag	12	17	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:44259671G>A	uc003tkq.2	-	23	2201	c.1991C>T	c.(1990-1992)CCG>CTG	p.P664L	CAMK2B_uc003tkp.2_Missense_Mutation_p.P540L|CAMK2B_uc003tkx.2_Missense_Mutation_p.P500L|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.P516L|CAMK2B_uc003tks.2_Missense_Mutation_p.P515L|CAMK2B_uc003tku.2_Missense_Mutation_p.P501L|CAMK2B_uc003tkv.2_Missense_Mutation_p.P477L|CAMK2B_uc003tkt.2_Missense_Mutation_p.P490L|CAMK2B_uc003tkw.2_Missense_Mutation_p.P447L|CAMK2B_uc010kyc.2_Missense_Mutation_p.P540L|CAMK2B_uc003tkn.2_Missense_Mutation_p.P297L	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	664					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						TCACTGCAGCGGGGCCACAGG	0.692													0	0	0	0.000602	0	4	19										A	44259671	G	A	44259671	3	1	54	1	0	0	0	0	1	0	0	0	2600	1116	39	2	13	2	CAMK2B	7	44259671	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	66653	44259671	114878992	451	15229										
CAMK2B	816	broad.mit.edu	37	chr7	44281927	44281927	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggagtgacggtgtcccactCaggggacgggaactgcagaa	16	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:44281927C>T	uc003tkq.2	-	10	919	c.709G>A	c.(709-711)GAG>AAG	p.E237K	CAMK2B_uc003tkp.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkx.2_Missense_Mutation_p.E237K|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.E237K|CAMK2B_uc003tks.2_Missense_Mutation_p.E237K|CAMK2B_uc003tku.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkv.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkt.2_Missense_Mutation_p.E237K|CAMK2B_uc003tkw.2_Missense_Mutation_p.E237K|CAMK2B_uc010kyc.2_Missense_Mutation_p.E237K	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	237	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						GTGTCCCACTCAGGGGACGGG	0.607													0	0	0	0.006122	0	16	127										T	44281927	C	T	44281927	3	4	54	1	0	0	0	0	1	0	0	0	2600	835	29	1	1350	1	CAMK2B	7	44281927	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	22256	44281927	114856736	452	15230										
ABCA13	154664	broad.mit.edu	37	chr7	48311969	48311969	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggctataataactagtctCcatgaatttggatttttgga	9	5	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:48311969C>G	uc003toq.2	+	17	2731	c.2706C>G	c.(2704-2706)CTC>CTG	p.L902L	ABCA13_uc010kyr.2_Silent_p.L405L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	902					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TAACTAGTCTCCATGAATTTG	0.393													0	0	0	0.008291	0	10	33										G	48311969	C	G	48311969	2	3	54	1	0	0	0	0	0	0	0	1	31	842	30	1		1	ABCA13	7	48311969	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4030042	48311969	110826694	453	15231										
ABCA13	154664	broad.mit.edu	37	chr7	48318381	48318381	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaacttcttaagctggtcaaGaaagtttcggggaagatgtc	11	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:48318381G>C	uc003toq.2	+	18	7615	c.7590G>C	c.(7588-7590)AAG>AAC	p.K2530N	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2530					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGCTGGTCAAGAAAGTTTCGG	0.413													0	0	0	0.00361	0	41	113										C	48318381	G	C	48318381	3	2	54	1	0	0	0	0	1	0	0	0	31	933	33	1	7489	1	ABCA13	7	48318381	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6412	48318381	110820282	454	15232										
HIP1	3092	broad.mit.edu	37	chr7	75172284	75172284	+	Missense_Mutation	SNP	C	C	T													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taggttggggctgtccttatCagctttcacctaccaggaca							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:75172284C>T	uc003uds.1	-	28	2817	c.2776G>A	c.(2776-2778)GAT>AAT	p.D926N	HIP1_uc011kfz.1_Missense_Mutation_p.D752N	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	926	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CTGTCCTTATCAGCTTTCACC	0.507			T	PDGFRB	CMML								0	0	0	0.004007	0	12	78										T	75172284	C	T	75172284	3	4	54	1	0	0	0	0	1	0	0	0	7114	826	29	1	353	1	HIP1	7	75172284	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	26853903	75172284	83966379	455	15233	72	2								
HIP1	3092	broad.mit.edu	37	chr7	75172291	75172291	+	Silent	SNP	C	C	T													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggctgtccttatcagctttCacctaccaggacaaagcaga							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:75172291C>T	uc003uds.1	-	28	2810	c.2769G>A	c.(2767-2769)GTG>GTA	p.V923V	HIP1_uc011kfz.1_Silent_p.V749V	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	923	Important for actin binding (By similarity).|I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TATCAGCTTTCACCTACCAGG	0.522			T	PDGFRB	CMML								0	0	0	0.00245	0	10	79										T	75172291	C	T	75172291	2	4	54	1	0	0	0	0	0	0	0	1	7114	813	29	1		1	HIP1	7	75172291	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7	75172291	83966372	456	15234	72	2								
SRCRB4D	136853	broad.mit.edu	37	chr7	76027118	76027118	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actcggccctgacacaggttCgcgccccctaccaggcgtac	10	18	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:76027118C>T	uc003ufb.2	-	6	933	c.585G>A	c.(583-585)GCG>GCA	p.A195A	ZP3_uc003ufc.3_Intron	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	195	SRCR 2.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						GACACAGGTTCGCGCCCCCTA	0.706													0	0	0	0.000602	0	4	30										T	76027118	C	T	76027118	2	4	54	1	0	0	0	0	0	0	0	1	15136	871	31	1		1	SRCRB4D	7	76027118	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	854827	76027118	83111545	457	15235										
AKAP9	10142	broad.mit.edu	37	chr7	91631200	91631200	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taaatattgaaaaacttaaaGataatttaggcattcactat	4	4	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:91631200G>C	uc003ulg.2	+	8	2194	c.1969G>C	c.(1969-1971)GAT>CAT	p.D657H	AKAP9_uc003ule.2_Missense_Mutation_p.D669H|AKAP9_uc003ulf.2_Missense_Mutation_p.D657H|AKAP9_uc003uli.2_Missense_Mutation_p.D282H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	669	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAACTTAAAGATAATTTAGG	0.323			T	BRAF	papillary thyroid								0	0	0	0.000602	0	4	21										C	91631200	G	C	91631200	3	2	54	1	0	0	0	0	1	0	0	0	459	942	33	1	1999	1	AKAP9	7	91631200	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	15604082	91631200	67507463	458	15236										
AKAP9	10142	broad.mit.edu	37	chr7	91722446	91722446	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atatacagcagaagcagtctCaaatgctggagatgcaagtg	11	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:91722446C>G	uc003ulg.2	+	39	9619	c.9394C>G	c.(9394-9396)CAA>GAA	p.Q3132E	AKAP9_uc003ulf.2_Missense_Mutation_p.Q3124E|AKAP9_uc003uli.2_Missense_Mutation_p.Q2755E|AKAP9_uc003ulj.2_Missense_Mutation_p.Q902E|AKAP9_uc003ull.2_Missense_Mutation_p.Q28E	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3136	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAGCAGTCTCAAATGCTGGA	0.378			T	BRAF	papillary thyroid								0	0	0	0.00308	0	6	36										G	91722446	C	G	91722446	3	3	54	1	0	0	0	0	1	0	0	0	459	827	29	1	9548	1	AKAP9	7	91722446	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	91246	91722446	67416217	459	15237										
ANKIB1	54467	broad.mit.edu	37	chr7	92027928	92027928	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acatcatggcttggtttcatGacatgaaccctcagagtatt	8	9	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:92027928G>C	uc003ulw.2	+	20	3311	c.2935G>C	c.(2935-2937)GAC>CAC	p.D979H	ANKIB1_uc010lew.1_Missense_Mutation_p.D248H	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	979							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTGGTTTCATGACATGAACCC	0.478													0	0	0	0.003954	0	20	96										C	92027928	G	C	92027928	3	2	54	1	0	0	0	0	1	0	0	0	630	1290	45	1	3009	1	ANKIB1	7	92027928	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	305482	92027928	67110735	460	15238										
PEX1	5189	broad.mit.edu	37	chr7	92118624	92118624	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacagctcagcaaaattcttCcagtcatcttcactaatgga	5	11	5	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:92118624C>A	uc003uly.2	-	23	3846	c.3750G>T	c.(3748-3750)TGG>TGT	p.W1250C	PEX1_uc011khr.1_Missense_Mutation_p.W1042C|PEX1_uc010ley.2_Missense_Mutation_p.W1193C|PEX1_uc011khs.1_Missense_Mutation_p.W928C	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	1250					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CAAAATTCTTCCAGTCATCTT	0.378													1	0	3.59834e-05	0.001168	3.71589e-05	5	25										A	92118624	C	A	92118624	3	1	54	1	0	0	0	0	1	0	0	0	11735	856	30	3	109	3	PEX1	7	92118624	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	90696	92118624	67020039	461	15239										
PEX1	5189	broad.mit.edu	37	chr7	92147127	92147127	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatgatgagtcaactggaatCtctgactcgttttcattaga	9	7	3	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:92147127C>T	uc003uly.2	-	5	798	c.702G>A	c.(700-702)GAG>GAA	p.E234E	PEX1_uc011khr.1_Silent_p.E26E|PEX1_uc010ley.2_Silent_p.E234E|PEX1_uc011khs.1_Intron|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	234					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CAACTGGAATCTCTGACTCGT	0.373													0	0	0	0.004672	0	3	23										T	92147127	C	T	92147127	2	4	54	1	0	0	0	0	0	0	0	1	11735	912	32	1		1	PEX1	7	92147127	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	28503	92147127	66991536	462	15240										
CALCR	799	broad.mit.edu	37	chr7	93055834	93055834	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagcagagcggttggaggggCgcctcccccaacgctggttc	16	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:93055834C>T	uc003umv.1	-	15	1622	c.1361G>A	c.(1360-1362)CGC>CAC	p.R454H	CALCR_uc011kia.1_Missense_Mutation_p.R234H|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.R420H|CALCR_uc003umw.2_Missense_Mutation_p.R420H	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	436	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GTTGGAGGGGCGCCTCCCCCA	0.562													0	0	0	0.010729	0	10	79										T	93055834	C	T	93055834	3	4	54	1	0	0	0	0	1	0	0	0	2579	768	27	2	169	2	CALCR	7	93055834	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	908707	93055834	66082829	463	15241										
LMTK2	22853	broad.mit.edu	37	chr7	97821789	97821789	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taaacctgccactttaagttCcagtttggataaccccaaag	6	11	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:97821789C>T	uc003upd.1	+	11	2305	c.2012C>T	c.(2011-2013)TCC>TTC	p.S671F		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	671					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					ACTTTAAGTTCCAGTTTGGAT	0.413													0	0	0	0.007413	0	17	99										T	97821789	C	T	97821789	3	4	54	1	0	0	0	0	1	0	0	0	8859	855	30	1	2054	1	LMTK2	7	97821789	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4765955	97821789	61316874	464	15242										
CYP3A4	1576	broad.mit.edu	37	chr7	99364028	99364028	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gactcagtttcttttgaattCtgagagtcaatcatcagctg	8	8	6	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:99364028C>T	uc003urv.1	-	9	941	c.837G>A	c.(835-837)CAG>CAA	p.Q279Q	CYP3A4_uc003urw.1_Silent_p.Q278Q|CYP3A4_uc011kiz.1_Silent_p.Q238Q|CYP3A4_uc011kja.1_Silent_p.Q230Q|CYP3A4_uc011kjb.1_Silent_p.Q129Q	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	279				Q -> HK (in Ref. 1; BAA00001/AAA35742).	alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	CTTTTGAATTCTGAGAGTCAA	0.448													0	0	0	0.001984	0	5	32										T	99364028	C	T	99364028	2	4	54	1	0	0	0	0	0	0	0	1	4178	912	32	1		1	CYP3A4	7	99364028	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1542239	99364028	59774635	465	15243										
ZSCAN21	7589	broad.mit.edu	37	chr7	99654714	99654714	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcctctgatggtaaaagtcGaggagaaagaagagaaaggc	15	5	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:99654714G>A	uc003uso.2	+	2	229	c.85G>A	c.(85-87)GAG>AAG	p.E29K	ZSCAN21_uc011kje.1_Missense_Mutation_p.E28K|ZSCAN21_uc003usn.1_Missense_Mutation_p.E28K	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	29					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			GGTAAAAGTCGAGGAGAAAGA	0.557													0	0	0	0.002299	0	22	111										A	99654714	G	A	99654714	3	1	54	1	0	0	0	0	1	0	0	0	18230	1059	37	1	87	1	ZSCAN21	7	99654714	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	290686	99654714	59483949	466	15244										
GATS	352954	broad.mit.edu	37	chr7	99869490	99869490	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagaacaggaaggcaagtttGatcaggcccgtaggtgaaca	14	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:99869490G>C	uc003uua.3	-	1	366	c.117C>G	c.(115-117)ATC>ATG	p.I39M	GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc010lgt.2_RNA|GATS_uc010lgu.2_RNA	NM_178831	NP_849153	Q8NAP1	GATS_HUMAN	GATS, stromal antigen 3 opposite strand	39											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGGCAAGTTTGATCAGGCCCG	0.677													0	0	0	0.006122	0	15	122										C	99869490	G	C	99869490	3	2	54	1	0	0	0	0	1	0	0	0	6264	1280	45	1	390	1	GATS	7	99869490	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	214776	99869490	59269173	467	15245										
MOSPD3	64598	broad.mit.edu	37	chr7	100212805	100212805	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catggtgttcctccggacctGagctccgtgctcaaccccca	9	17	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:100212805G>A	uc003uvq.2	+	6	909	c.707G>A	c.(706-708)TGA>TAA	p.*236*	MOSPD3_uc003uvr.2_Silent_p.*236*|MOSPD3_uc003uvs.2_Silent_p.*236*|MOSPD3_uc003uvt.2_Silent_p.*226*	NM_001040097	NP_001035186	O75425	MSPD3_HUMAN	motile sperm domain containing 3 isoform a	236						integral to membrane	structural molecule activity			ovary(2)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CTCCGGACCTGAGCTCCGTGC	0.622													0	0	0	0.012319	0	16	103										A	100212805	G	A	100212805	2	1	54	1	0	0	0	0	0	0	0	1	9717	1285	45	1		1	MOSPD3	7	100212805	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	343315	100212805	58925858	468	15246										
EPHB4	2050	broad.mit.edu	37	chr7	100404054	100404054	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acacttacgtcctgattgctCatgtcccagtacggcctctc	7	15	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:100404054C>T	uc003uwn.1	-	14	2963	c.2472G>A	c.(2470-2472)ATG>ATA	p.M824I	EPHB4_uc003uwm.1_Missense_Mutation_p.M731I|EPHB4_uc010lhj.1_Missense_Mutation_p.M824I	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	824	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCTGATTGCTCATGTCCCAGT	0.547													0	0	0	0.012319	0	18	78										T	100404054	C	T	100404054	3	4	54	1	0	0	0	0	1	0	0	0	5177	826	29	1	507	1	EPHB4	7	100404054	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	191249	100404054	58734609	469	15247										
PSMC2	5701	broad.mit.edu	37	chr7	103008184	103008184	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggacccacatatttaagattCacgctcgttcaatgagtgtt	8	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:103008184C>T	uc003vbs.2	+	11	1142	c.1072C>T	c.(1072-1074)CAC>TAC	p.H358Y	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.H221Y	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	358					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						ATTTAAGATTCACGCTCGTTC	0.338													0	0	0	0.001855	0	13	48										T	103008184	C	T	103008184	3	4	54	1	0	0	0	0	1	0	0	0	12686	826	29	1	1114	1	PSMC2	7	103008184	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2604130	103008184	56130479	470	15248										
LAMB1	3912	broad.mit.edu	37	chr7	107599732	107599732	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atggtgtagtcctggcagttCaagcactccccagtcactgg	11	12	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:107599732C>T	uc003vew.2	-	20	2987	c.2652G>A	c.(2650-2652)TTG>TTA	p.L884L	LAMB1_uc003vev.2_Silent_p.L908L	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	884	Laminin EGF-like 8.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTGGCAGTTCAAGCACTCCC	0.542													0	0	0	0.013114	0	35	238										T	107599732	C	T	107599732	2	4	54	1	0	0	0	0	0	0	0	1	8610	825	29	1		1	LAMB1	7	107599732	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4591548	107599732	51538931	471	15249										
DOCK4	9732	broad.mit.edu	37	chr7	111509670	111509670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctcttgccgctctgcttctGtgatccggtccacgtaccat	9	15	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:111509670G>A	uc003vfx.2	-	21	2338	c.2069C>T	c.(2068-2070)ACA>ATA	p.T690I	DOCK4_uc003vfw.2_Missense_Mutation_p.T131I|DOCK4_uc003vfy.2_Missense_Mutation_p.T690I|DOCK4_uc003vga.1_Missense_Mutation_p.T295I	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	690					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTCTGCTTCTGTGATCCGGTC	0.423													0	0	0	0.00499	0	12	47										A	111509670	G	A	111509670	3	1	54	1	0	0	0	0	1	0	0	0	4689	1377	48	2	3959	2	DOCK4	7	111509670	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3909938	111509670	47628993	472	15250										
PTPRZ1	5803	broad.mit.edu	37	chr7	121652246	121652246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taaaagtgaaataatatatgGaaatgagactgaactgcaaa	8	3	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:121652246G>A	uc003vjy.2	+	12	3541	c.3146G>A	c.(3145-3147)GGA>GAA	p.G1049E	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1049	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATAATATATGGAAATGAGACT	0.333													0	0	0	0.000602	0	4	20										A	121652246	G	A	121652246	3	1	54	1	0	0	0	0	1	0	0	0	12814	1174	41	1	3192	1	PTPRZ1	7	121652246	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10142576	121652246	37486417	473	15251										
TAS2R16	50833	broad.mit.edu	37	chr7	122635052	122635052	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgcttggattgcagtgacCagtgctatgatgttgtatct	11	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:122635052C>T	uc003vkl.1	-	1	703	c.637G>A	c.(637-639)GGT>AGT	p.G213S		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	213	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						TTGCAGTGACCAGTGCTATGA	0.463													0	0	0	0.006214	0	7	44										T	122635052	C	T	122635052	3	4	54	1	0	0	0	0	1	0	0	0	15566	594	21	2	242	2	TAS2R16	7	122635052	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	982806	122635052	36503611	474	15252										
FLNC	2318	broad.mit.edu	37	chr7	128490515	128490515	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aacctggtcatccccttcgcGgtgcagaaaggggagctcac	12	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:128490515G>A	uc003vnz.3	+	32	5585	c.5376G>A	c.(5374-5376)GCG>GCA	p.A1792A	FLNC_uc003voa.3_Silent_p.A1759A	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1792	Filamin 16.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCCCCTTCGCGGTGCAGAAAG	0.527													0	0	0	0.010818	0	27	142										A	128490515	G	A	128490515	2	1	54	1	0	0	0	0	0	0	0	1	5935	1103	39	2		2	FLNC	7	128490515	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5855463	128490515	30648148	475	15253										
CPA2	1358	broad.mit.edu	37	chr7	129912983	129912983	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagcaaagtgaatattggctCttcttttgagaaccggccta	10	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:129912983C>T	uc003vpq.2	+	5	471	c.452C>T	c.(451-453)TCT>TTT	p.S151F	CPA2_uc011kpc.1_Missense_Mutation_p.S151F	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	151					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					AATATTGGCTCTTCTTTTGAG	0.473													0	0	0	0.004482	0	7	53										T	129912983	C	T	129912983	3	4	54	1	0	0	0	0	1	0	0	0	3790	913	32	1	470	1	CPA2	7	129912983	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1422468	129912983	29225680	476	15254										
OR2F2	135948	broad.mit.edu	37	chr7	143632802	143632802	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccatcaactctcttgtgcaGactgctatcacctttcagct	5	14	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:143632802G>A	uc011ktv.1	+	1	477	c.477G>A	c.(475-477)CAG>CAA	p.Q159Q		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					CTCTTGTGCAGACTGCTATCA	0.527													0	0	0	0.00499	0	14	93										A	143632802	G	A	143632802	2	1	54	1	0	0	0	0	0	0	0	1	10997	933	33	1		1	OR2F2	7	143632802	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	13719819	143632802	15505861	477	15255										
GIMAP6	474344	broad.mit.edu	37	chr7	150327201	150327201	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttctgggggattctcctgGggaatttgttcatattcttc	10	8	5	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:150327201G>C	uc003whn.2	-	2	454	c.30C>G	c.(28-30)CCC>CCG	p.P10P	GIMAP6_uc003whm.2_Missense_Mutation_p.P5R	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	10							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GATTCTCCTGGGGAATTTGTT	0.423													0	0	0	0.012319	0	20	136										C	150327201	G	C	150327201	2	2	54	1	0	0	0	0	0	0	0	1	6383	1219	43	4		4	GIMAP6	7	150327201	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6694399	150327201	8811462	478	15256										
GIMAP5	55340	broad.mit.edu	37	chr7	150439547	150439547	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggggactgctacctgctctCtgccccggggccccacgtcc	12	19	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr7:150439547C>G	uc003whr.1	+	3	672	c.320C>G	c.(319-321)TCT>TGT	p.S107C	GIMAP5_uc010lpu.2_5'UTR	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	107	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TACCTGCTCTCTGCCCCGGGG	0.582													0	0	0	0.00499	0	12	117										G	150439547	C	G	150439547	3	3	54	1	0	0	0	0	1	0	0	0	6382	913	32	1	326	1	GIMAP5	7	150439547	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	112346	150439547	8699116	479	15257										
RP1L1	94137	broad.mit.edu	37	chr8	10468839	10468839	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcctcaaggtcttctcctcGgacagcccccgagaccccgc	8	20	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:10468839G>A	uc003wtc.2	-	4	2998	c.2769C>T	c.(2767-2769)TCC>TCT	p.S923S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	923					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCTTCTCCTCGGACAGCCCCC	0.697													0	0	0	0.00308	0	7	44										A	10468839	G	A	10468839	2	1	54	1	0	0	0	0	0	0	0	1	13533	1103	39	2		2	RP1L1	8	10468839	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		10468839	135895183	480	15258										
XPO7	23039	broad.mit.edu	37	chr8	21848409	21848409	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccttctacacagcacttgggCgtctcctcatggtggattta	9	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:21848409C>T	uc003xaa.3	+	18	2122	c.2020C>T	c.(2020-2022)CGT>TGT	p.R674C	XPO7_uc010lti.2_Missense_Mutation_p.R683C|XPO7_uc010ltk.2_Missense_Mutation_p.R675C	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	674					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		AGCACTTGGGCGTCTCCTCAT	0.418													0	0	0	0.008361	0	23	173										T	21848409	C	T	21848409	3	4	54	1	0	0	0	0	1	0	0	0	17446	768	27	2	2142	2	XPO7	8	21848409	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11379570	21848409	124515613	481	15259										
FAM160B2	64760	broad.mit.edu	37	chr8	21958231	21958231	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctggggctcaccagagcctGagagctatgaggacaccctg	13	13	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:21958231G>A	uc011kyx.1	+	11	1519	c.1468G>A	c.(1468-1470)GAG>AAG	p.E490K	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	490											0						ACCAGAGCCTGAGAGCTATGA	0.617													0	0	0	0.003271	0	29	176										A	21958231	G	A	21958231	3	1	54	1	0	0	0	0	1	0	0	0	5471	1291	45	1	1309	1	FAM160B2	8	21958231	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	109822	21958231	124405791	482	15260										
PRKDC	5591	broad.mit.edu	37	chr8	48690357	48690357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgatgctgtacataaggcCcgtttctttcattggtaaca	8	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:48690357C>T	uc003xqi.2	-	85	11989	c.11932G>A	c.(11932-11934)GGC>AGC	p.G3978S	PRKDC_uc003xqj.2_Missense_Mutation_p.G3947S|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3978	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TACATAAGGCCCGTTTCTTTC	0.498								NHEJ					0	0	0	0.001855	0	13	102										T	48690357	C	T	48690357	3	4	54	1	0	0	0	0	1	0	0	0	12521	623	22	2	466	2	PRKDC	8	48690357	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	26732126	48690357	97673665	483	15261										
PRKDC	5591	broad.mit.edu	37	chr8	48772207	48772207	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accagtggcaggtctagggtCttgggagctgtatgaatagc	15	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:48772207C>T	uc003xqi.2	-	47	6229	c.6172G>A	c.(6172-6174)GAC>AAC	p.D2058N	PRKDC_uc003xqj.2_Missense_Mutation_p.D2058N|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2058					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGTCTAGGGTCTTGGGAGCTG	0.443								NHEJ					0	0	0	0.012213	0	23	173										T	48772207	C	T	48772207	3	4	54	1	0	0	0	0	1	0	0	0	12521	913	32	1	6378	1	PRKDC	8	48772207	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	81850	48772207	97591815	484	15262										
LYN	4067	broad.mit.edu	37	chr8	56922538	56922538	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccgtgtggagaactgcccaGatgagctctatgacattatg	11	10	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:56922538G>C	uc003xsk.3	+	13	1690	c.1408G>C	c.(1408-1410)GAT>CAT	p.D470H	LYN_uc003xsl.3_Missense_Mutation_p.D449H	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	470	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GAACTGCCCAGATGAGCTCTA	0.483													0	0	0	0.008291	0	10	73										C	56922538	G	C	56922538	3	2	54	1	0	0	0	0	1	0	0	0	9107	942	33	1	1454	1	LYN	8	56922538	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8150331	56922538	89441484	485	15263										
ASPH	444	broad.mit.edu	37	chr8	62438579	62438579	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccagtcccctttttccctCaggttttcatcctcaggcag	6	16	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:62438579C>T	uc003xuj.2	-	22	2126	c.1857G>A	c.(1855-1857)CTG>CTA	p.L619L	ASPH_uc011leg.1_Silent_p.L590L	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	619	Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTTTTTCCCTCAGGTTTTCAT	0.493													0	0	0	0.004482	0	7	55										T	62438579	C	T	62438579	2	4	54	1	0	0	0	0	0	0	0	1	1053	813	29	1		1	ASPH	8	62438579	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5516041	62438579	83925443	486	15264										
VCPIP1	80124	broad.mit.edu	37	chr8	67547599	67547599	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaagtacaatgcttgccatCagccatacctaaaaagggga	8	9	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:67547599C>T	uc003xwn.2	-	3	3065	c.2806G>A	c.(2806-2808)GAT>AAT	p.D936N		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	936					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TGCTTGCCATCAGCCATACCT	0.323													0	0	0	0.006214	0	6	36										T	67547599	C	T	67547599	3	4	54	1	0	0	0	0	1	0	0	0	17138	826	29	1	866	1	VCPIP1	8	67547599	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5109020	67547599	78816423	487	15265										
SULF1	23213	broad.mit.edu	37	chr8	70515500	70515500	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgggctcgacacacctcctGatgtggacggcaagtctgtc	12	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:70515500G>A	uc010lza.1	+	11	1852	c.1135G>A	c.(1135-1137)GAT>AAT	p.D379N	SULF1_uc003xyd.2_Missense_Mutation_p.D379N|SULF1_uc003xye.2_Missense_Mutation_p.D379N|SULF1_uc003xyf.2_Missense_Mutation_p.D379N|SULF1_uc003xyg.2_Missense_Mutation_p.D379N|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	379					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CACACCTCCTGATGTGGACGG	0.542													0	0	0	0.007291	0	29	110										A	70515500	G	A	70515500	3	1	54	1	0	0	0	0	1	0	0	0	15369	1290	45	1	1161	1	SULF1	8	70515500	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2967901	70515500	75848522	488	15266										
SLCO5A1	81796	broad.mit.edu	37	chr8	70585257	70585257	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaattctccctgggtgctGaaagctgggcaagatctagt	13	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:70585257G>A	uc003xyl.2	-	10	3101	c.2394C>T	c.(2392-2394)TTC>TTT	p.F798F	SLCO5A1_uc010lzb.2_Silent_p.F743F|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	798	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCTGGGTGCTGAAAGCTGGGC	0.577													0	0	0	0.001368	0	11	135										A	70585257	G	A	70585257	2	1	54	1	0	0	0	0	0	0	0	1	14731	1281	45	1		1	SLCO5A1	8	70585257	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	69757	70585257	75778765	489	15267										
C8orf84	157869	broad.mit.edu	37	chr8	73979650	73979650	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aacttttttccaagttccttGacaccgaggattaccaattg	6	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:73979650G>C	uc003xzf.2	-	5	926	c.721C>G	c.(721-723)CAA>GAA	p.Q241E		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	241					immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0						CAAGTTCCTTGACACCGAGGA	0.373													0	0	0	0.004482	0	6	80										C	73979650	G	C	73979650	3	2	54	1	0	0	0	0	1	0	0	0	2440	1299	45	1	77	1	C8orf84	8	73979650	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3394393	73979650	72384372	490	15268										
JPH1	56704	broad.mit.edu	37	chr8	75227753	75227753	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcgcagcgaggccagcgagGtacgcagcggtgagcggatc	18	11	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:75227753G>C	uc003yae.2	-	2	522	c.482C>G	c.(481-483)ACC>AGC	p.T161S	JPH1_uc003yaf.2_Missense_Mutation_p.T161S|JPH1_uc003yag.1_Missense_Mutation_p.T25S	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	161	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GGCCAGCGAGGTACGCAGCGG	0.731													0	0	0	0.00308	0	5	48										C	75227753	G	C	75227753	3	2	54	1	0	0	0	0	1	0	0	0	7960	1261	44	4	1519	4	JPH1	8	75227753	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1248103	75227753	71136269	491	15269										
E2F5	1875	broad.mit.edu	37	chr8	86121423	86121423	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatcaatctaaagagtcattCaggacctatccatgtgctgc	8	10	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:86121423C>T	uc003ycz.3	+	6	699	c.662C>T	c.(661-663)TCA>TTA	p.S221L	E2F5_uc003yda.3_Missense_Mutation_p.S221L|E2F5_uc010mab.2_Missense_Mutation_p.S60L|E2F5_uc003ydb.3_Missense_Mutation_p.S40L	NM_001951	NP_001942	Q15329	E2F5_HUMAN	E2F transcription factor 5 isoform 1	221					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1						AAGAGTCATTCAGGACCTATC	0.393													0	0	0	0.001984	0	5	38										T	86121423	C	T	86121423	3	4	54	1	0	0	0	0	1	0	0	0	4870	838	29	1	684	1	E2F5	8	86121423	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10893670	86121423	60242599	492	15270										
DECR1	1666	broad.mit.edu	37	chr8	91029411	91029411	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaagctttgcaatctaaattCttttcacctcttcaaaaagc	4	10	5	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:91029411C>G	uc003yek.1	+	2	270	c.129C>G	c.(127-129)TTC>TTG	p.F43L	DECR1_uc011lgc.1_Missense_Mutation_p.F34L|DECR1_uc011lgd.1_Intron	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor	43					fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)			AATCTAAATTCTTTTCACCTC	0.333													0	0	0	0.001168	0	6	32										G	91029411	C	G	91029411	3	3	54	1	0	0	0	0	1	0	0	0	4382	912	32	1	135	1	DECR1	8	91029411	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4907988	91029411	55334611	493	15271										
TMEM67	91147	broad.mit.edu	37	chr8	94767349	94767349	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttccttgtggagctaaccaGaggcaagatgcccgaggtaa	13	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:94767349G>C	uc011lgk.1	+	1	278	c.207G>C	c.(205-207)CAG>CAC	p.Q69H	TMEM67_uc010mau.2_Missense_Mutation_p.Q69H|TMEM67_uc010mav.2_Missense_Mutation_p.Q69H|TMEM67_uc010mat.1_5'UTR|TMEM67_uc010maw.2_Missense_Mutation_p.Q69H|TMEM67_uc003yga.3_5'UTR	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	69					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GAGCTAACCAGAGGCAAGATG	0.527													0	0	0	0.003954	0	19	196										C	94767349	G	C	94767349	3	2	54	1	0	0	0	0	1	0	0	0	16193	933	33	1	209	1	TMEM67	8	94767349	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3737938	94767349	51596673	494	15272										
INTS8	55656	broad.mit.edu	37	chr8	95892357	95892357	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttttggaagatcaaagccatCggccagacagagttgaatgc	11	8	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:95892357C>T	uc003yhb.2	+	27	3009	c.2883C>T	c.(2881-2883)ATC>ATT	p.I961I	INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Silent_p.I771I	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	961					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TCAAAGCCATCGGCCAGACAG	0.388													0	0	0	0.00308	0	5	76										T	95892357	C	T	95892357	2	4	54	1	0	0	0	0	0	0	0	1	7784	874	31	1		1	INTS8	8	95892357	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1125008	95892357	50471665	495	15273										
TSPYL5	85453	broad.mit.edu	37	chr8	98288992	98288992	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccacaatcttgtcagactCaatggagctgtggtttgaaa	9	9	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:98288992C>T	uc003yhy.2	-	1	1185	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	361					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					TTGTCAGACTCAATGGAGCTG	0.478													0	0	0	0.010504	0	19	153										T	98288992	C	T	98288992	3	4	54	1	0	0	0	0	1	0	0	0	16659	835	29	1	176	1	TSPYL5	8	98288992	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2396635	98288992	48075030	496	15274										
POP1	10940	broad.mit.edu	37	chr8	99135698	99135698	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgaaaaacctttccaagctCaaaaacaaggtaaaatacac	5	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:99135698C>G	uc003yij.3	+	2	233	c.133C>G	c.(133-135)CAA>GAA	p.Q45E	POP1_uc011lgv.1_Missense_Mutation_p.Q45E|POP1_uc003yik.2_Missense_Mutation_p.Q45E	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	45					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			TTTCCAAGCTCAAAAACAAGG	0.274													0	0	0	0.000602	0	4	22										G	99135698	C	G	99135698	3	3	54	1	0	0	0	0	1	0	0	0	12251	827	29	1	135	1	POP1	8	99135698	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	846706	99135698	47228324	497	15275										
POP1	10940	broad.mit.edu	37	chr8	99170408	99170408	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggcttgctggatatgctgtCcagccagcctgcagcgcaga	13	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:99170408C>T	uc003yij.3	+	16	3084	c.2984C>T	c.(2983-2985)TCC>TTC	p.S995F	POP1_uc011lgv.1_Missense_Mutation_p.S995F|POP1_uc003yik.2_Missense_Mutation_p.S995F	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	995					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GATATGCTGTCCAGCCAGCCT	0.547													0	0	0	0.007413	0	20	167										T	99170408	C	T	99170408	3	4	54	1	0	0	0	0	1	0	0	0	12251	855	30	1	3042	1	POP1	8	99170408	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	34710	99170408	47193614	498	15276										
KCNS2	3788	broad.mit.edu	37	chr8	99440621	99440621	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggagaagtgggacgagcaGagtgaccaggagagcaccac	16	9	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:99440621G>C	uc003yin.2	+	2	764	c.414G>C	c.(412-414)CAG>CAC	p.Q138H		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	138	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGGACGAGCAGAGTGACCAGG	0.577													0	0	0	0.001984	0	5	57										C	99440621	G	C	99440621	3	2	54	1	0	0	0	0	1	0	0	0	8089	933	33	1	416	1	KCNS2	8	99440621	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	270213	99440621	46923401	499	15277										
RGS22	26166	broad.mit.edu	37	chr8	101014551	101014551	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcgatctctgtaagttattCtccggaactgctcaatgtct	7	10	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:101014551C>G	uc003yjb.1	-	18	2864	c.2669G>C	c.(2668-2670)AGA>ACA	p.R890T	RGS22_uc003yja.1_Missense_Mutation_p.R709T|RGS22_uc003yjc.1_Missense_Mutation_p.R878T|RGS22_uc011lgz.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	890	RGS 1.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			GTAAGTTATTCTCCGGAACTG	0.323													0	0	0	0.00308	0	6	29										G	101014551	C	G	101014551	3	3	54	1	0	0	0	0	1	0	0	0	13305	913	32	1	1165	1	RGS22	8	101014551	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1573930	101014551	45349471	500	15278										
PKHD1L1	93035	broad.mit.edu	37	chr8	110510690	110510690	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtttggcttatttccaaacaGagctcattaattgttggaag	9	6	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:110510690G>C	uc003yne.2	+	66	10704	c.10600_splice	c.e66-1	p.S3534_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTCCAAACAGAGCTCATTAA	0.289										HNSCC(38;0.096)			0	0	0	0.008291	0	11	39										C	110510690	G	C	110510690	5	2	54	1	0	0	0	0	0	0	1	0	11972	956	33	1	10861	1	PKHD1L1	8	110510690	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9496139	110510690	35853332	501	15279										
COL14A1	7373	broad.mit.edu	37	chr8	121383405	121383405	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctttagctccccatccagatCagccagagttcacccctgtc	6	17	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:121383405C>T	uc003yox.2	+	48	5591	c.5326C>T	c.(5326-5328)CAG>TAG	p.Q1776*		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1776	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CCATCCAGATCAGCCAGAGTT	0.522													0	0	0	0.004656	0	18	199										T	121383405	C	T	121383405	4	4	54	1	0	0	0	0	0	1	0	0	3671	827	29	1	5512	1	COL14A1	8	121383405	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10872715	121383405	24980617	502	15280										
MTBP	27085	broad.mit.edu	37	chr8	121514760	121514760	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagtggaacctaattcctcAagtctaatggaaaccaatcc	6	12	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:121514760A>G	uc003ypc.1	+	15	1683	c.1638A>G	c.(1636-1638)TCA>TCG	p.S546S		NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	546	Interaction with MDM2 (By similarity).				cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			CTAATTCCTCAAGTCTAATGG	0.299													0	0	0	0.004672	0	3	14										G	121514760	A	G	121514760	2	3	54	1	0	0	0	0	0	0	0	1	9912	117	5	5		5	MTBP	8	121514760	Silent	SNP	A	TCGA-DK-A2I4-01A-11D-A21A-08	131355	121514760	24849262	503	15281										
RNF139	11236	broad.mit.edu	37	chr8	125487428	125487428	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcggcgctcgaagtggcgctCcgggtgccctgcctttacat	14	14	0	0	rs147204700		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:125487428C>G	uc003yrc.2	+	1	421	c.78C>G	c.(76-78)CTC>CTG	p.L26L	uc003yrb.2_5'Flank	NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	26					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			AAGTGGCGCTCCGGGTGCCCT	0.662									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	0.00245	0	12	102										G	125487428	C	G	125487428	2	3	54	1	0	0	0	0	0	0	0	1	13442	842	30	1		1	RNF139	8	125487428	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3972668	125487428	20876594	504	15282			4	61		3	3	100	C		6.188864e-06
RNF139	11236	broad.mit.edu	37	chr8	125487452	125487452	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgccctgcctttacatcatCgacgccatcttcaactccta	5	16	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:125487452C>G	uc003yrc.2	+	1	445	c.102C>G	c.(100-102)ATC>ATG	p.I34M	uc003yrb.2_5'Flank	NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	34					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TTTACATCATCGACGCCATCT	0.637									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	0.004656	0	20	169										G	125487452	C	G	125487452	3	3	54	1	0	0	0	0	1	0	0	0	13442	874	31	1	104	1	RNF139	8	125487452	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	24	125487452	20876570	505	15283			4	61		3	3	100	C		6.188864e-06
RNF139	11236	broad.mit.edu	37	chr8	125487527	125487527	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccagatcttcctccggctCtttggtaagggaacagggta	11	11	2	1	rs142523795		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:125487527C>G	uc003yrc.2	+	1	520	c.177C>G	c.(175-177)CTC>CTG	p.L59L	uc003yrb.2_5'Flank	NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	59	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TCCTCCGGCTCTTTGGTAAGG	0.627									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	0.010504	0	16	167										G	125487527	C	G	125487527	2	3	54	1	0	0	0	0	0	0	0	1	13442	900	32	1		1	RNF139	8	125487527	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	75	125487527	20876495	506	15284			4	61		3	3	100	C		6.188864e-06
EFR3A	23167	broad.mit.edu	37	chr8	132982779	132982779	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aacatctgcgtctcagcgttGaattcgaagcaaatgattta	8	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:132982779G>C	uc003yte.2	+	10	1249	c.1048G>C	c.(1048-1050)GAA>CAA	p.E350Q		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	350						plasma membrane	binding	p.S348fs*15(1)		ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TCTCAGCGTTGAATTCGAAGC	0.393													0	0	0	0.004672	0	3	30										C	132982779	G	C	132982779	3	2	54	1	0	0	0	0	1	0	0	0	4958	1291	45	1	1086	1	EFR3A	8	132982779	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7495252	132982779	13381243	507	15285										
PHF20L1	51105	broad.mit.edu	37	chr8	133848934	133848934	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaattgtgcgatgtatttgtGagatggatgaggagaatggc	15	2	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:133848934G>C	uc003ytt.2	+	16	2384	c.2059G>C	c.(2059-2061)GAG>CAG	p.E687Q	PHF20L1_uc011lja.1_Missense_Mutation_p.E661Q	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	687	PHD-type.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			ATGTATTTGTGAGATGGATGA	0.408													0	0	0	0.004482	0	6	54										C	133848934	G	C	133848934	3	2	54	1	0	0	0	0	1	0	0	0	11832	1291	45	1	2213	1	PHF20L1	8	133848934	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	866155	133848934	12515088	508	15286										
WISP1	8840	broad.mit.edu	37	chr8	134225348	134225348	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggcctctactgtgactacaGcggggaccgcccgaggtacg	15	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:134225348G>A	uc003yub.2	+	2	387	c.311G>A	c.(310-312)AGC>AAC	p.S104N	WISP1_uc003yuc.2_Missense_Mutation_p.S104N|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Missense_Mutation_p.S104N|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	104	IGFBP N-terminal.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TGTGACTACAGCGGGGACCGC	0.612													0	0	0	0.00361	0	32	252										A	134225348	G	A	134225348	3	1	54	1	0	0	0	0	1	0	0	0	17369	971	34	2	317	2	WISP1	8	134225348	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	376414	134225348	12138674	509	15287										
PTK2	5747	broad.mit.edu	37	chr8	141810664	141810664	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atggttagggatggtgccgtCactgtcagaggctaacggag	16	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:141810664C>A	uc003yvu.2	-	12	1217	c.987G>T	c.(985-987)GTG>GTT	p.V329V	PTK2_uc011ljq.1_5'UTR|PTK2_uc003yvp.2_5'UTR|PTK2_uc003yvq.2_5'UTR|PTK2_uc003yvr.2_Silent_p.V228V|PTK2_uc003yvs.2_Silent_p.V329V|PTK2_uc003yvt.2_Silent_p.V351V|PTK2_uc003yvv.2_Silent_p.V216V|PTK2_uc011ljr.1_Silent_p.V329V	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	329	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			ATGGTGCCGTCACTGTCAGAG	0.468													1	0	3.59834e-05	0.001168	3.71589e-05	6	66										A	141810664	C	A	141810664	2	1	54	1	0	0	0	0	0	0	0	1	12762	813	29	3		3	PTK2	8	141810664	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7585316	141810664	4553358	510	15288										
EEF1D	1936	broad.mit.edu	37	chr8	144668986	144668986	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgaacttgtcgaaccagatCttctcatgtgctaggaagtt	9	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:144668986C>T	uc011lki.1	-	2	299	c.30G>A	c.(28-30)AAG>AAA	p.K10K	EEF1D_uc003yyp.1_Silent_p.K376K|EEF1D_uc003yyq.1_Silent_p.K426K|EEF1D_uc011lkj.1_Silent_p.K375K|EEF1D_uc003yyr.2_Silent_p.K376K|EEF1D_uc003yyt.2_Silent_p.K376K|EEF1D_uc011lkk.1_Silent_p.K10K|EEF1D_uc003yys.2_Silent_p.K10K|EEF1D_uc003yyv.2_Silent_p.K10K|EEF1D_uc003yyu.2_Silent_p.K10K|EEF1D_uc011lkl.1_Silent_p.K10K	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	10					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CGAACCAGATCTTCTCATGTG	0.547													0	0	0	0.00499	0	13	251										T	144668986	C	T	144668986	2	4	54	1	0	0	0	0	0	0	0	1	4926	912	32	1		1	EEF1D	8	144668986	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2858322	144668986	1695036	511	15289										
ZNF623	9831	broad.mit.edu	37	chr8	144733392	144733392	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccaagctgcttctgcaccaGattattcacactggagaaaa	7	11	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:144733392G>C	uc003yzd.2	+	1	1439	c.1350G>C	c.(1348-1350)CAG>CAC	p.Q450H	ZNF623_uc011lkp.1_Missense_Mutation_p.Q410H|ZNF623_uc003yzc.2_Missense_Mutation_p.Q410H	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	450	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TTCTGCACCAGATTATTCACA	0.463													0	0	0	0.00499	0	13	96										C	144733392	G	C	144733392	3	2	54	1	0	0	0	0	1	0	0	0	18044	933	33	1	1352	1	ZNF623	8	144733392	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	64406	144733392	1630630	512	15290										
EPPK1	83481	broad.mit.edu	37	chr8	144947098	144947098	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcggccagcagcttctccttCagctccagccccaccagacc	8	20	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:144947098C>T	uc003zaa.1	-	1	337	c.324G>A	c.(322-324)CTG>CTA	p.L108L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	108	Plectin 2.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTTCTCCTTCAGCTCCAGCC	0.677													0	0	0	0.001168	0	5	78										T	144947098	C	T	144947098	2	4	54	1	0	0	0	0	0	0	0	1	5190	813	29	1		1	EPPK1	8	144947098	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	213706	144947098	1416924	513	15291										
PLEC	5339	broad.mit.edu	37	chr8	144995185	144995185	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaggtcccgccgctgctctGccgtgaagtattccgagttg	13	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:144995185G>T	uc003zaf.1	-	32	9385	c.9215C>A	c.(9214-9216)GCA>GAA	p.A3072E	PLEC_uc003zab.1_Missense_Mutation_p.A2935E|PLEC_uc003zac.1_Missense_Mutation_p.A2939E|PLEC_uc003zad.2_Missense_Mutation_p.A2935E|PLEC_uc003zae.1_Missense_Mutation_p.A2903E|PLEC_uc003zag.1_Missense_Mutation_p.A2913E|PLEC_uc003zah.2_Missense_Mutation_p.A2921E|PLEC_uc003zaj.2_Missense_Mutation_p.A2962E	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3072	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCGCTGCTCTGCCGTGAAGTA	0.597													1	0	3.76054e-38	0.00361	4.07156e-38	64	160										T	144995185	G	T	144995185	3	4	54	1	0	0	0	0	1	0	0	0	12052	1319	46	4	4843	4	PLEC	8	144995185	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	48087	144995185	1368837	514	15292										
PLEC	5339	broad.mit.edu	37	chr8	144998327	144998327	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagcgccaggatctcctcctCcacctgccgccgctgcctca	8	21	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:144998327C>T	uc003zaf.1	-	31	6351	c.6181G>A	c.(6181-6183)GAG>AAG	p.E2061K	PLEC_uc003zab.1_Missense_Mutation_p.E1924K|PLEC_uc003zac.1_Missense_Mutation_p.E1928K|PLEC_uc003zad.2_Missense_Mutation_p.E1924K|PLEC_uc003zae.1_Missense_Mutation_p.E1892K|PLEC_uc003zag.1_Missense_Mutation_p.E1902K|PLEC_uc003zah.2_Missense_Mutation_p.E1910K|PLEC_uc003zaj.2_Missense_Mutation_p.E1951K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2061	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ATCTCCTCCTCCACCTGCCGC	0.697													0	0	0	0.006214	0	8	78										T	144998327	C	T	144998327	3	4	54	1	0	0	0	0	1	0	0	0	12052	864	30	1	7881	1	PLEC	8	144998327	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3142	144998327	1365695	515	15293										
PLEC	5339	broad.mit.edu	37	chr8	145007044	145007044	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtggctgcccagctgcgcctCcacgctgggcaggtccacac	13	17	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:145007044C>G	uc003zaf.1	-	14	2235	c.2065G>C	c.(2065-2067)GAG>CAG	p.E689Q	PLEC_uc003zab.1_Missense_Mutation_p.E552Q|PLEC_uc003zac.1_Missense_Mutation_p.E556Q|PLEC_uc003zad.2_Missense_Mutation_p.E552Q|PLEC_uc003zae.1_Missense_Mutation_p.E520Q|PLEC_uc003zag.1_Missense_Mutation_p.E530Q|PLEC_uc003zah.2_Missense_Mutation_p.E538Q|PLEC_uc003zaj.2_Missense_Mutation_p.E579Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	689	Spectrin 1.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCTGCGCCTCCACGCTGGGC	0.677													0	0	0	0.001984	0	5	77										G	145007044	C	G	145007044	3	3	54	1	0	0	0	0	1	0	0	0	12052	864	30	1	12065	1	PLEC	8	145007044	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	8717	145007044	1356978	516	15294										
PLEC	5339	broad.mit.edu	37	chr8	145007080	145007080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacaccccactcagcgccatCcacacggtgctggttctcct	7	19	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:145007080C>T	uc003zaf.1	-	14	2199	c.2029G>A	c.(2029-2031)GAT>AAT	p.D677N	PLEC_uc003zab.1_Missense_Mutation_p.D540N|PLEC_uc003zac.1_Missense_Mutation_p.D544N|PLEC_uc003zad.2_Missense_Mutation_p.D540N|PLEC_uc003zae.1_Missense_Mutation_p.D508N|PLEC_uc003zag.1_Missense_Mutation_p.D518N|PLEC_uc003zah.2_Missense_Mutation_p.D526N|PLEC_uc003zaj.2_Missense_Mutation_p.D567N	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	677	Spectrin 1.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCAGCGCCATCCACACGGTGC	0.662													0	0	0	0.006214	0	6	81										T	145007080	C	T	145007080	3	4	54	1	0	0	0	0	1	0	0	0	12052	855	30	1	12101	1	PLEC	8	145007080	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	36	145007080	1356942	517	15295										
PARP10	84875	broad.mit.edu	37	chr8	145057596	145057596	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgagcgcccggtccagctCctccacatcctgctcaaagg	9	18	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:145057596C>T	uc003zal.3	-	8	2269	c.2161G>A	c.(2161-2163)GAG>AAG	p.E721K	PARP10_uc003zak.3_Missense_Mutation_p.E418K|PARP10_uc011lku.1_Missense_Mutation_p.E733K|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.E712K	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	721	Myc binding.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGTCCAGCTCCTCCACATCC	0.692													0	0	0	0.008291	0	6	38										T	145057596	C	T	145057596	3	4	54	1	0	0	0	0	1	0	0	0	11455	864	30	1	932	1	PARP10	8	145057596	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	50516	145057596	1306426	518	15296										
GRINA	2907	broad.mit.edu	37	chr8	145065951	145065951	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aactgggatgacaagagcatCcgacaggccttcatccgcaa	10	12	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:145065951C>G	uc003zan.1	+	3	637	c.471C>G	c.(469-471)ATC>ATG	p.I157M	GRINA_uc003zao.1_Missense_Mutation_p.I157M|GRINA_uc003zap.1_Missense_Mutation_p.I157M	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	157						integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACAAGAGCATCCGACAGGCCT	0.612													0	0	0	0.008871	0	15	138										G	145065951	C	G	145065951	3	3	54	1	0	0	0	0	1	0	0	0	6785	845	30	1	477	1	GRINA	8	145065951	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	8355	145065951	1298071	519	15297										
SPATC1	375686	broad.mit.edu	37	chr8	145095934	145095934	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccacgcaccacagaaccgtCgacgaagagcatgatggagg	12	12	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr8:145095934C>T	uc011lkw.1	+	3	1334	c.1232C>T	c.(1231-1233)TCG>TTG	p.S411L	SPATC1_uc011lkx.1_Missense_Mutation_p.S411L	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	411										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACAGAACCGTCGACGAAGAGC	0.632													0	0	0	0.010504	0	21	164										T	145095934	C	T	145095934	3	4	54	1	0	0	0	0	1	0	0	0	15016	893	31	1	1242	1	SPATC1	8	145095934	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	29983	145095934	1268088	520	15298										
VLDLR	7436	broad.mit.edu	37	chr9	2652822	2652822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggtggctacttgatgtggcGgaattggcaacacaagaaca	13	7	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:2652822G>A	uc003zhk.1	+	18	2856	c.2459G>A	c.(2458-2460)CGG>CAG	p.R820Q	VLDLR_uc003zhl.1_Missense_Mutation_p.R792Q|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Missense_Mutation_p.R751Q	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	820	Cytoplasmic (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		TTGATGTGGCGGAATTGGCAA	0.423													0	0	0	0.001855	0	10	80										A	2652822	G	A	2652822	3	1	54	1	0	0	0	0	1	0	0	0	17171	1116	39	2	2529	2	VLDLR	9	2652822	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		2652822	138560609	521	15299										
NFIB	4781	broad.mit.edu	37	chr9	14313493	14313493	+	Silent	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acatgtacctgagtgagacaGatgggagaatacatcatgac							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:14313493G>A	uc003zle.2	-	1	453	c.18C>T	c.(16-18)ATC>ATT	p.I6I	NFIB_uc003zlf.2_Silent_p.I6I|NFIB_uc011lmo.1_Silent_p.I6I	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	6	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GAGTGAGACAGATGGGAGAAT	0.443			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								0	0	0	0.00499	0	12	120										A	14313493	G	A	14313493	2	1	54	1	0	0	0	0	0	0	0	1	10371	932	33	1		1	NFIB	9	14313493	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	11660671	14313493	126899938	522	15300	73	2								
NFIB	4781	broad.mit.edu	37	chr9	14313500	14313500	+	Missense_Mutation	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgagtgagacagatgggaGaatacatcatgacttcgcct							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:14313500G>A	uc003zle.2	-	1	446	c.11C>T	c.(10-12)TCT>TTT	p.S4F	NFIB_uc003zlf.2_Missense_Mutation_p.S4F|NFIB_uc011lmo.1_Missense_Mutation_p.S4F	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	4	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ACAGATGGGAGAATACATCAT	0.448			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								0	0	0	0.004007	0	11	113										A	14313500	G	A	14313500	3	1	54	1	0	0	0	0	1	0	0	0	10371	942	33	1	1287	1	NFIB	9	14313500	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7	14313500	126899931	523	15301	73	2								
CNTLN	54875	broad.mit.edu	37	chr9	17484452	17484452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttcacggtcagatttagagGaaatattagacacagaagat	9	5	2	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:17484452G>A	uc003zmz.2	+	24	4038	c.4012G>A	c.(4012-4014)GAA>AAA	p.E1338K	CNTLN_uc003zmy.2_Missense_Mutation_p.E1339K|CNTLN_uc010mio.2_Missense_Mutation_p.E1018K	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1339						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AGATTTAGAGGAAATATTAGA	0.323													0	0	0	0.001168	0	5	34										A	17484452	G	A	17484452	3	1	54	1	0	0	0	0	1	0	0	0	3639	1175	41	1	4139	1	CNTLN	9	17484452	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3170952	17484452	123728979	524	15302										
IFNA4	3441	broad.mit.edu	37	chr9	21187338	21187338	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaactggtggccatcaaactCctcctcggggaatccgaaat	10	12	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:21187338C>G	uc003zon.2	-	1	261	c.193G>C	c.(193-195)GAG>CAG	p.E65Q		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	65					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CCATCAAACTCCTCCTCGGGG	0.512													0	0	0	0.00308	0	8	100										G	21187338	C	G	21187338	3	3	54	1	0	0	0	0	1	0	0	0	7539	864	30	1	380	1	IFNA4	9	21187338	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3702886	21187338	120026093	525	15303										
KLHL9	55958	broad.mit.edu	37	chr9	21334174	21334174	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctttgcagcataatccatccGagggtcttccaaccttagcc	7	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:21334174G>A	uc003zoy.2	-	1	1256	c.685C>T	c.(685-687)CGG>TGG	p.R229W	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	229	BACK.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		TAATCCATCCGAGGGTCTTCC	0.428													0	0	0	0.00245	0	14	78										A	21334174	G	A	21334174	3	1	54	1	0	0	0	0	1	0	0	0	8396	1057	37	1	1172	1	KLHL9	9	21334174	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	146836	21334174	119879257	526	15304										
TOPORS	10210	broad.mit.edu	37	chr9	32541498	32541498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aatgttactgggctggttctCcaaatcagaaacaaaggtgc	10	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:32541498C>T	uc003zrb.2	-	3	3192	c.3025G>A	c.(3025-3027)GAG>AAG	p.E1009K	TOPORS_uc003zrc.2_Missense_Mutation_p.E942K	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	1009					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		GGCTGGTTCTCCAAATCAGAA	0.428													0	0	0	0.001168	0	6	100										T	32541498	C	T	32541498	3	4	54	1	0	0	0	0	1	0	0	0	16367	864	30	1	116	1	TOPORS	9	32541498	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11207324	32541498	108671933	527	15305										
UBAP2	55833	broad.mit.edu	37	chr9	33948389	33948389	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taccaagatgactgaggactGaggactgggatgttgggggc	17	6	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:33948389G>T	uc003ztq.1	-	13	1366	c.1253C>A	c.(1252-1254)TCA>TAA	p.S418*	UBAP2_uc011loc.1_Nonsense_Mutation_p.S327*|UBAP2_uc011lod.1_Nonsense_Mutation_p.S151*|UBAP2_uc011loe.1_Nonsense_Mutation_p.S173*|UBAP2_uc011lof.1_Nonsense_Mutation_p.S343*|UBAP2_uc011log.1_Nonsense_Mutation_p.S364*|UBAP2_uc003ztr.2_Nonsense_Mutation_p.S290*|UBAP2_uc003zts.2_Nonsense_Mutation_p.S51*	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	418										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ACTGAGGACTGAGGACTGGGA	0.483													1	0	4.68919e-08	0.008291	4.93278e-08	9	139										T	33948389	G	T	33948389	4	4	54	1	0	0	0	0	0	1	0	0	16834	1294	45	3	2174	3	UBAP2	9	33948389	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1406891	33948389	107265042	528	15306										
KIF24	347240	broad.mit.edu	37	chr9	34257247	34257247	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tactggcgtaaagaccttttCagtggttggtattttaactt	9	6	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:34257247C>T	uc003zua.3	-	11	2478	c.2358G>A	c.(2356-2358)CTG>CTA	p.L786L	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	786					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			AAGACCTTTTCAGTGGTTGGT	0.517													0	0	0	0.008291	0	9	80										T	34257247	C	T	34257247	2	4	54	1	0	0	0	0	0	0	0	1	8292	813	29	1		1	KIF24	9	34257247	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	308858	34257247	106956184	529	15307										
FANCG	2189	broad.mit.edu	37	chr9	35076535	35076535	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggcagtagtaattctacctCaatgagaaactgcggggctt	11	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:35076535C>G	uc003zwb.1	-	8	1462	c.970G>C	c.(970-972)GAG>CAG	p.E324Q	FANCG_uc003zwa.1_Missense_Mutation_p.E66Q|FANCG_uc010mkj.1_Missense_Mutation_p.E66Q|FANCG_uc011lot.1_Missense_Mutation_p.E324Q	NM_004629	NP_004620	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	324					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|large_intestine(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AATTCTACCTCAATGAGAAAC	0.463			Mis|N|F|S			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.001368	0	10	70										G	35076535	C	G	35076535	3	3	54	1	0	0	0	0	1	0	0	0	5668	835	29	1	926	1	FANCG	9	35076535	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	819288	35076535	106136896	530	15308										
FANCG	2189	broad.mit.edu	37	chr9	35077090	35077090	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggttccctgtgatcagctCctggagacctgaggacagtc	13	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:35077090C>G	uc003zwb.1	-	6	1147	c.655G>C	c.(655-657)GAG>CAG	p.E219Q	FANCG_uc003zwa.1_5'UTR|FANCG_uc010mkj.1_5'UTR|FANCG_uc011lot.1_Missense_Mutation_p.E219Q	NM_004629	NP_004620	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	219					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|large_intestine(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTGATCAGCTCCTGGAGACCT	0.567			Mis|N|F|S			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.006122	0	15	67										G	35077090	C	G	35077090	3	3	54	1	0	0	0	0	1	0	0	0	5668	864	30	1	1249	1	FANCG	9	35077090	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	555	35077090	106136341	531	15309										
UNC13B	10497	broad.mit.edu	37	chr9	35310490	35310490	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagcagcagtaggtatggctCctcctgtaatgtgagtcaag	12	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:35310490C>T	uc003zwq.2	+	9	1080	c.788C>T	c.(787-789)TCC>TTC	p.S263F	UNC13B_uc010mkl.1_Missense_Mutation_p.S263F|UNC13B_uc003zwr.2_Missense_Mutation_p.S263F	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	263					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			AGGTATGGCTCCTCCTGTAAT	0.468													0	0	0	0.004007	0	14	107										T	35310490	C	T	35310490	3	4	54	1	0	0	0	0	1	0	0	0	16982	855	30	1	822	1	UNC13B	9	35310490	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	233400	35310490	105902941	532	15310										
FRMPD1	22844	broad.mit.edu	37	chr9	37744481	37744481	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acagcctgccttgtgggccaGatggaagacagccaagcagg	14	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:37744481G>A	uc004aag.1	+	16	2496	c.2452G>A	c.(2452-2454)GAT>AAT	p.D818N	FRMPD1_uc004aah.1_Missense_Mutation_p.D818N	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	818						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TTGTGGGCCAGATGGAAGACA	0.547													0	0	0	0.010729	0	12	124										A	37744481	G	A	37744481	3	1	54	1	0	0	0	0	1	0	0	0	6057	942	33	1	2510	1	FRMPD1	9	37744481	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2433991	37744481	103468950	533	15311										
PGM5	5239	broad.mit.edu	37	chr9	71080072	71080072	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggatggagattcttctcaaaTctgatggactcaggacgttg	12	7	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:71080072T>A	uc004agr.2	+	7	1336	c.1107T>A	c.(1105-1107)AAT>AAA	p.N369K		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	369					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						TCTTCTCAAATCTGATGGACT	0.453													0	0	0	0.008291	0	9	73										A	71080072	T	A	71080072	3	1	54	1	0	0	0	0	1	0	0	0	11801	1432	50	5	1133	5	PGM5	9	71080072	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	33335591	71080072	70133359	534	15312										
SMC5	23137	broad.mit.edu	37	chr9	72930435	72930435	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taatgagttacctttgctgtCagtatcatattcatgaagtt	7	6	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:72930435C>G	uc004ahr.2	+	13	1864	c.1747C>G	c.(1747-1749)CAG>GAG	p.Q583E		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	583	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						CCTTTGCTGTCAGTATCATAT	0.343													0	0	0	0.000602	0	4	27										G	72930435	C	G	72930435	3	3	54	1	0	0	0	0	1	0	0	0	14786	827	29	1	1797	1	SMC5	9	72930435	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1850363	72930435	68282996	535	15313										
PRUNE2	158471	broad.mit.edu	37	chr9	79322056	79322056	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcccaagctctggattcatCctcagcaacgtggcagttgg	10	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:79322056C>T	uc010mpk.2	-	8	5258	c.5134G>A	c.(5134-5136)GAT>AAT	p.D1712N		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1712					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTGGATTCATCCTCAGCAACG	0.443													0	0	0	0.001984	0	5	39										T	79322056	C	T	79322056	3	4	54	1	0	0	0	0	1	0	0	0	12641	855	30	1	4180	1	PRUNE2	9	79322056	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6391621	79322056	61891375	536	15314										
ZNF462	58499	broad.mit.edu	37	chr9	109694815	109694815	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagtattgctcgtttgtttCtgctttcaggcacaagtaag	9	9	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:109694815C>G	uc004bcz.2	+	5	6390	c.6101C>G	c.(6100-6102)TCT>TGT	p.S2034C	ZNF462_uc010mto.2_Missense_Mutation_p.S1943C|ZNF462_uc004bda.2_Missense_Mutation_p.S1942C|ZNF462_uc011lvz.1_5'Flank	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2034	C2H2-type 19.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TCGTTTGTTTCTGCTTTCAGG	0.517													0	0	0	0.001855	0	10	98										G	109694815	C	G	109694815	3	3	54	1	0	0	0	0	1	0	0	0	17923	913	32	1	6115	1	ZNF462	9	109694815	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	30372759	109694815	31518616	537	15315										
CTNNAL1	8727	broad.mit.edu	37	chr9	111755015	111755015	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgcagcctttatcactcctGttttgtctgtaaaaattgtg	7	8	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:111755015G>C	uc004bdo.1	-	3	458	c.416C>G	c.(415-417)ACA>AGA	p.T139R	CTNNAL1_uc010mtt.1_Missense_Mutation_p.T139R|CTNNAL1_uc004bdp.1_Missense_Mutation_p.T139R	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	139					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		TATCACTCCTGTTTTGTCTGT	0.378													0	0	0	0.009096	0	3	27										C	111755015	G	C	111755015	3	2	54	1	0	0	0	0	1	0	0	0	4015	1377	48	4	1856	4	CTNNAL1	9	111755015	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2060200	111755015	29458416	538	15316										
C9orf84	158401	broad.mit.edu	37	chr9	114454446	114454446	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccttgattctatattaattaGaaaaggagtattctgcccta	6	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:114454446G>C	uc004bfr.2	-	25	3754	c.3619C>G	c.(3619-3621)CTA>GTA	p.L1207V	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.L1168V|C9orf84_uc010mug.2_Missense_Mutation_p.L1118V	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	1207										ovary(2)	2						ATATTAATTAGAAAAGGAGTA	0.373													0	0	0	0.001168	0	6	28										C	114454446	G	C	114454446	3	2	54	1	0	0	0	0	1	0	0	0	2500	933	33	1	723	1	C9orf84	9	114454446	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2699431	114454446	26758985	539	15317										
NDUFA8	4702	broad.mit.edu	37	chr9	124906608	124906608	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggatccggtcttggtcttGagtgatagggattctccggt	15	7	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:124906608G>C	uc004blv.2	-	4	573	c.431C>G	c.(430-432)TCA>TGA	p.S144*		NM_014222	NP_055037	P51970	NDUA8_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	144					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1					NADH(DB00157)	TCTTGGTCTTGAGTGATAGGG	0.517													0	0	0	0.004482	0	6	84										C	124906608	G	C	124906608	4	2	54	1	0	0	0	0	0	1	0	0	10271	1294	45	1	91	1	NDUFA8	9	124906608	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10452162	124906608	16306823	540	15318										
RC3H2	54542	broad.mit.edu	37	chr9	125621301	125621301	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaggtgggagggaggactCtggaacgttattggacctca	16	7	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:125621301C>A	uc010mwc.1	-	12	2171	c.1930G>T	c.(1930-1932)GAG>TAG	p.E644*	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Nonsense_Mutation_p.E644*|RC3H2_uc004bne.3_Nonsense_Mutation_p.E644*	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	644	Pro-rich.					cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						AGGGAGGACTCTGGAACGTTA	0.507													1	0	3.27435e-08	0.00245	3.44725e-08	15	62										A	125621301	C	A	125621301	4	1	54	1	0	0	0	0	0	1	0	0	13167	922	32	3	1763	3	RC3H2	9	125621301	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	714693	125621301	15592130	541	15319										
RC3H2	54542	broad.mit.edu	37	chr9	125642878	125642878	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctaatttcacaaaccttatCaatgatagactgcatgtgtg	6	8	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:125642878C>G	uc010mwc.1	-	6	1196	c.955G>C	c.(955-957)GAT>CAT	p.D319H	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.D319H|RC3H2_uc004bne.3_Missense_Mutation_p.D319H|RC3H2_uc011lzf.1_Missense_Mutation_p.D56H|RC3H2_uc011lzg.1_Missense_Mutation_p.D319H|SNORD90_uc004bnf.1_5'Flank	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	319						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						CAAACCTTATCAATGATAGAC	0.368													0	0	0	0.004672	0	3	48										G	125642878	C	G	125642878	3	3	54	1	0	0	0	0	1	0	0	0	13167	826	29	1	2762	1	RC3H2	9	125642878	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	21577	125642878	15570553	542	15320										
ANGPTL2	23452	broad.mit.edu	37	chr9	129870633	129870633	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgcgagttcatgttgcggctCtccttgcgcagcagcttcac	11	14	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:129870633C>T	uc004bqr.1	-	2	878	c.378G>A	c.(376-378)GAG>GAA	p.E126E	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Intron	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	126					multicellular organismal development|signal transduction	extracellular space	receptor binding				0						TGTTGCGGCTCTCCTTGCGCA	0.612													0	0	0	0.001368	0	10	41										T	129870633	C	T	129870633	2	4	54	1	0	0	0	0	0	0	0	1	614	912	32	1		1	ANGPTL2	9	129870633	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4227755	129870633	11342798	543	15321										
STXBP1	6812	broad.mit.edu	37	chr9	130434372	130434372	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agatgctgaagaagatgcctCagtaccagaaagagctcagc	11	9	2	6			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:130434372C>T	uc004brl.2	+	12	1203	c.1006C>T	c.(1006-1008)CAG>TAG	p.Q336*	STXBP1_uc004brk.2_Nonsense_Mutation_p.Q336*	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	336					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						GAAGATGCCTCAGTACCAGAA	0.473													0	0	0	0.00333	0	20	69										T	130434372	C	T	130434372	4	4	54	1	0	0	0	0	0	1	0	0	15351	827	29	1	1052	1	STXBP1	9	130434372	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	563739	130434372	10779059	544	15322										
TOR2A	27433	broad.mit.edu	37	chr9	130494388	130494388	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctgctcgtcttcagggaaGaaggtggtgctgtccagcac	14	10	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:130494388G>A	uc004brs.3	-	5	946	c.891C>T	c.(889-891)TTC>TTT	p.F297F	TOR2A_uc004brt.3_3'UTR|TOR2A_uc004brw.3_3'UTR|TOR2A_uc011maj.1_3'UTR|TOR2A_uc004bru.3_Silent_p.F135F|TOR2A_uc004brv.3_RNA|TOR2A_uc004brx.1_3'UTR	NM_001085347	NP_001078816	Q5JU69	TOR2A_HUMAN	torsin family 2, member A isoform a	297					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0						CTTCAGGGAAGAAGGTGGTGC	0.637													0	0	0	0.009535	0	28	117										A	130494388	G	A	130494388	2	1	54	1	0	0	0	0	0	0	0	1	16372	933	33	1		1	TOR2A	9	130494388	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	60016	130494388	10719043	545	15323										
COQ4	51117	broad.mit.edu	37	chr9	131087436	131087436	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttcagacatggtcgcagttCtaggggagaccacaggacac	12	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:131087436C>T	uc004bur.3	+	3	564	c.217C>T	c.(217-219)CTA>TTA	p.L73L	TRUB2_uc004buq.1_5'Flank|COQ4_uc011max.1_Silent_p.L73L|COQ4_uc004bus.2_Silent_p.L49L|COQ4_uc010mxy.2_Silent_p.L49L	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	73					ubiquinone biosynthetic process	mitochondrial inner membrane					0						GGTCGCAGTTCTAGGGGAGAC	0.438													0	0	0	0.006214	0	7	35										T	131087436	C	T	131087436	2	4	54	1	0	0	0	0	0	0	0	1	3747	912	32	1		1	COQ4	9	131087436	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	593048	131087436	10125995	546	15324										
WDR34	89891	broad.mit.edu	37	chr9	131396209	131396209	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcatcctgggtttgcttgatCaaaactgtgggtttctggga	12	7	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:131396209C>G	uc004bvq.1	-	9	1549	c.1425G>C	c.(1423-1425)TTG>TTC	p.L475F	WDR34_uc004bvs.1_Missense_Mutation_p.L466F|WDR34_uc004bvr.1_Missense_Mutation_p.L447F	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	475						cytoplasm				central_nervous_system(2)|skin(1)	3						TTTGCTTGATCAAAACTGTGG	0.517													0	0	0	0.001168	0	5	52										G	131396209	C	G	131396209	3	3	54	1	0	0	0	0	1	0	0	0	17285	825	29	1	189	1	WDR34	9	131396209	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	308773	131396209	9817222	547	15325										
USP20	10868	broad.mit.edu	37	chr9	132630421	132630421	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagaaacgggagggtgaccgGagcccatcagaagatgagtt	16	7	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:132630421G>C	uc004bys.2	+	11	1039	c.828G>C	c.(826-828)CGG>CGC	p.R276R	USP20_uc004byr.2_Silent_p.R276R|USP20_uc004byt.1_Silent_p.R276R	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	276					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				AGGGTGACCGGAGCCCATCAG	0.662													0	0	0	0.007291	0	24	166										C	132630421	G	C	132630421	2	2	54	1	0	0	0	0	0	0	0	1	17049	1161	41	1		1	USP20	9	132630421	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1234212	132630421	8583010	548	15326										
USP20	10868	broad.mit.edu	37	chr9	132630629	132630629	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caaactcggagcaagtggacGaggacgctgatgtggacact	14	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:132630629G>A	uc004bys.2	+	11	1247	c.1036G>A	c.(1036-1038)GAG>AAG	p.E346K	USP20_uc004byr.2_Missense_Mutation_p.E346K|USP20_uc004byt.1_Missense_Mutation_p.E346K	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	346					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				GCAAGTGGACGAGGACGCTGA	0.667													0	0	0	0.007413	0	18	133										A	132630629	G	A	132630629	3	1	54	1	0	0	0	0	1	0	0	0	17049	1059	37	1	1070	1	USP20	9	132630629	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	208	132630629	8582802	549	15327										
BAT2L1	84726	broad.mit.edu	37	chr9	134308165	134308165	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatgggcaaacaagcaggatCagcaagacccaaagaggtaa	12	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:134308165C>T	uc004can.3	+	2	332	c.277C>T	c.(277-279)CAG>TAG	p.Q93*	BAT2L1_uc004cam.1_Nonsense_Mutation_p.Q93*	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	93							protein binding				0						CAAGCAGGATCAGCAAGACCC	0.562													0	0	0	0.001368	0	10	74										T	134308165	C	T	134308165	4	4	54	1	0	0	0	0	0	1	0	0	1320	827	29	1	283	1	BAT2L1	9	134308165	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1677536	134308165	6905266	550	15328										
DBH	1621	broad.mit.edu	37	chr9	136501627	136501627	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggctcggctccccgtgagaGccccctcccctatcacatcc	9	20	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:136501627G>A	uc004cel.2	+	1	143	c.134G>A	c.(133-135)AGC>AAC	p.S45N		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	45	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCCCGTGAGAGCCCCCTCCCC	0.647													0	0	0	0.001855	0	13	58										A	136501627	G	A	136501627	3	1	54	1	0	0	0	0	1	0	0	0	4250	971	34	2	136	2	DBH	9	136501627	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2193462	136501627	4711804	551	15329										
DBH	1621	broad.mit.edu	37	chr9	136507468	136507468	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccgaaccggagttgccctCagacgcgtgcaccatggagg	13	15	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:136507468C>G	uc004cel.2	+	3	635	c.626C>G	c.(625-627)TCA>TGA	p.S209*		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	209	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GAGTTGCCCTCAGACGCGTGC	0.602													0	0	0	0.004672	0	3	45										G	136507468	C	G	136507468	4	3	54	1	0	0	0	0	0	1	0	0	4250	838	29	1	636	1	DBH	9	136507468	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5841	136507468	4705963	552	15330										
GPSM1	26086	broad.mit.edu	37	chr9	139250941	139250941	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagcaatgcagggcacctccGaggccacggcgagccccagg	14	16	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:139250941G>T	uc004chd.2	+	13	1980	c.1760G>T	c.(1759-1761)CGA>CTA	p.R587L	GPSM1_uc011mdu.1_Missense_Mutation_p.R78L|GPSM1_uc004che.2_Missense_Mutation_p.R78L	NM_001145638	NP_001139110	Q86YR5	GPSM1_HUMAN	G-protein signaling modulator 1 (AGS3-like, C.	587					cell differentiation|nervous system development|signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|plasma membrane	binding|GTPase activator activity				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.39e-06)|Epithelial(140;3.24e-06)		GGGCACCTCCGAGGCCACGGC	0.716													1	0	8.60227e-14	0.004007	9.19089e-14	14	56										T	139250941	G	T	139250941	3	4	54	1	0	0	0	0	1	0	0	0	6734	1058	37	3	1977	3	GPSM1	9	139250941	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2743473	139250941	1962490	553	15331										
TRAF2	7186	broad.mit.edu	37	chr9	139794080	139794080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actgtgctgcctgtgttcacGagggcatatatgaagaaggc	13	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr9:139794080G>A	uc010nbu.2	+	4	396	c.223G>A	c.(223-225)GAG>AAG	p.E75K	TRAF2_uc010nbv.1_Missense_Mutation_p.E75K|TRAF2_uc004cjv.2_Missense_Mutation_p.E75K|TRAF2_uc011mek.1_Missense_Mutation_p.E64K|TRAF2_uc010nbw.2_Missense_Mutation_p.E75K	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	75					activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CTGTGTTCACGAGGGCATATA	0.383													0	0	0	0.006122	0	15	78										A	139794080	G	A	139794080	3	1	54	1	0	0	0	0	1	0	0	0	16435	1059	37	1	229	1	TRAF2	9	139794080	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	543139	139794080	1419351	554	15332										
GDI2	2665	broad.mit.edu	37	chr10	5810189	5810189	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctcacctgactttcgattGacttggttctgtggaataat	8	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:5810189G>C	uc001iil.3	-	8	1269	c.978C>G	c.(976-978)GTC>GTG	p.V326V	GDI2_uc001iim.3_Silent_p.V281V|GDI2_uc009xid.2_Silent_p.V330V	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	326					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						ACTTTCGATTGACTTGGTTCT	0.408													0	0	0	0.012319	0	17	89										C	5810189	G	C	5810189	2	2	54	1	0	0	0	0	0	0	0	1	6321	1277	45	1		1	GDI2	10	5810189	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		5810189	129724558	555	15333										
NMT2	9397	broad.mit.edu	37	chr10	15175327	15175327	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttggcgtacgttgtctttatCtggttcaattgcaccatgag	10	8	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:15175327C>G	uc001inz.1	-	4	511	c.427G>C	c.(427-429)GAT>CAT	p.D143H	NMT2_uc001ioa.1_Missense_Mutation_p.D130H|NMT2_uc009xjo.1_Missense_Mutation_p.D143H|NMT2_uc010qbz.1_5'UTR	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	143					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						TTGTCTTTATCTGGTTCAATT	0.398													0	0	0	0.00245	0	10	85										G	15175327	C	G	15175327	3	3	54	1	0	0	0	0	1	0	0	0	10504	913	32	1	1105	1	NMT2	10	15175327	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	9365138	15175327	120359420	556	15334										
VIM	7431	broad.mit.edu	37	chr10	17276805	17276805	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcacctgtgaagtggatgcCcttaaaggaaccgtgagtac	11	10	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:17276805C>T	uc001iou.2	+	6	1409	c.996C>T	c.(994-996)GCC>GCT	p.A332A	VIM_uc001iov.1_Silent_p.A332A|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.A332A|VIM_uc001ioy.1_Silent_p.A332A|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Intron|VIM_uc001ipc.1_Silent_p.A332A	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	332	Rod.|Coil 2.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						AAGTGGATGCCCTTAAAGGAA	0.517													0	0	0	0.000602	0	4	48										T	17276805	C	T	17276805	2	4	54	1	0	0	0	0	0	0	0	1	17163	610	22	2		2	VIM	10	17276805	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2101478	17276805	118257942	557	15335										
C10orf140	387640	broad.mit.edu	37	chr10	21804708	21804708	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgattttaatattgtgcaGaaatggcaatgtcttgtcgc	9	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:21804708G>A	uc009xkd.2	-	4	4297	c.2044C>T	c.(2044-2046)CTG>TTG	p.L682L	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	601						nucleus	nucleotide binding			ovary(1)	1						ATATTGTGCAGAAATGGCAAT	0.433													0	0	0	0.001984	0	6	48										A	21804708	G	A	21804708	2	1	54	1	0	0	0	0	0	0	0	1	1595	933	33	1		1	C10orf140	10	21804708	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4527903	21804708	113730039	558	15336										
ARMC3	219681	broad.mit.edu	37	chr10	23321936	23321936	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaaggaatcttctaccatcGagctttgcttttcaaggtgt	8	8	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:23321936G>A	uc001irm.3	+	18	2476	c.2393G>A	c.(2392-2394)CGA>CAA	p.R798Q	ARMC3_uc010qcv.1_Missense_Mutation_p.R791Q|ARMC3_uc010qcw.1_Missense_Mutation_p.R535Q	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	798							binding				0						TTCTACCATCGAGCTTTGCTT	0.363													0	0	0	0.004482	0	5	21										A	23321936	G	A	23321936	3	1	54	1	0	0	0	0	1	0	0	0	952	1058	37	1	2459	1	ARMC3	10	23321936	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1517228	23321936	112212811	559	15337										
KIAA1462	57608	broad.mit.edu	37	chr10	30317490	30317490	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcccgtgctggctgcctctCacatcaggccactgtcccct	9	18	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:30317490C>G	uc001iux.2	-	2	1646	c.1587G>C	c.(1585-1587)GTG>GTC	p.V529V	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.V391V|KIAA1462_uc009xle.1_Silent_p.V529V	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	529										ovary(4)	4						GGCTGCCTCTCACATCAGGCC	0.612													0	0	0	0.00623	0	32	217										G	30317490	C	G	30317490	2	3	54	1	0	0	0	0	0	0	0	1	8234	813	29	1		1	KIAA1462	10	30317490	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6995554	30317490	105217257	560	15338										
LYZL2	119180	broad.mit.edu	37	chr10	30915075	30915075	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggttgttctccttcagctttCcgcgtctgcaccacgcgaag	10	14	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:30915075C>T	uc001ivk.2	-	3	408	c.395G>A	c.(394-396)GGA>GAA	p.G132E		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	86					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				CTTCAGCTTTCCGCGTCTGCA	0.572													0	0	0	0.012319	0	17	139										T	30915075	C	T	30915075	3	4	54	1	0	0	0	0	1	0	0	0	9132	855	30	1	201	1	LYZL2	10	30915075	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	597585	30915075	104619672	561	15339										
PARD3	56288	broad.mit.edu	37	chr10	34420503	34420503	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatcatgattgctaggagttGatctgttactgaaagagaga	12	4	2	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:34420503G>C	uc010qej.1	-	23	3437	c.3437C>G	c.(3436-3438)TCA>TGA	p.S1146*	PARD3_uc010qek.1_Nonsense_Mutation_p.S1143*|PARD3_uc010qel.1_Nonsense_Mutation_p.S1109*|PARD3_uc010qem.1_Nonsense_Mutation_p.S1130*|PARD3_uc010qen.1_Nonsense_Mutation_p.S1100*|PARD3_uc010qeo.1_Nonsense_Mutation_p.S1063*|PARD3_uc010qep.1_Nonsense_Mutation_p.S1056*|PARD3_uc010qeq.1_Nonsense_Mutation_p.S1034*	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1146					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GCTAGGAGTTGATCTGTTACT	0.423													0	0	0	0.003163	0	13	82										C	34420503	G	C	34420503	4	2	54	1	0	0	0	0	0	1	0	0	11443	1294	45	1	645	1	PARD3	10	34420503	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3505428	34420503	101114244	562	15340										
RBP3	5949	broad.mit.edu	37	chr10	48389979	48389979	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccccacacagggcagcaccCcgctgccctcccacgtctgg	9	21	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:48389979C>G	uc001jez.2	-	1	1013	c.899G>C	c.(898-900)GGG>GCG	p.G300A		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	300	4 X approximate tandem repeats.|1.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGGCAGCACCCCGCTGCCCTC	0.677													0	0	0	0.008291	0	8	34										G	48389979	C	G	48389979	3	3	54	1	0	0	0	0	1	0	0	0	13157	623	22	4	2860	4	RBP3	10	48389979	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	13969476	48389979	87144768	563	15341										
ERCC6	2074	broad.mit.edu	37	chr10	50740821	50740821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggccctctcctcggagctgCtgatgcgcaccccacagcag	11	17	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:50740821C>T	uc001jhs.3	-	2	344	c.190G>A	c.(190-192)GCA>ACA	p.A64T	PGBD3_uc009xoe.2_Missense_Mutation_p.A64T|PGBD3_uc001jhu.2_Missense_Mutation_p.A64T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	64					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CTCGGAGCTGCTGATGCGCAC	0.607								Direct_reversal_of_damage|NER					0	0	0	0.003954	0	24	76										T	50740821	C	T	50740821	3	4	54	1	0	0	0	0	1	0	0	0	5217	797	28	2	4371	2	ERCC6	10	50740821	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2350842	50740821	84793926	564	15342										
ANK3	288	broad.mit.edu	37	chr10	61833285	61833285	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccctcttagttctgacaactCatcgtcatggtattctattg	6	11	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:61833285C>G	uc001jky.2	-	37	7546	c.7354G>C	c.(7354-7356)GAG>CAG	p.E2452Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2452					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TCTGACAACTCATCGTCATGG	0.403													0	0	0	0.00308	0	8	39										G	61833285	C	G	61833285	3	3	54	1	0	0	0	0	1	0	0	0	622	835	29	1	6120	1	ANK3	10	61833285	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11092464	61833285	73701462	565	15343										
NEUROG3	50674	broad.mit.edu	37	chr10	71332658	71332658	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcagcctccctcttccgcctCtgcgcagttcccccgtgtgc	9	20	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:71332658C>T	uc001jpp.2	-	2	300	c.142G>A	c.(142-144)GAG>AAG	p.E48K		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	48					central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						TCTTCCGCCTCTGCGCAGTTC	0.721													0	0	0	0.010729	0	10	34										T	71332658	C	T	71332658	3	4	54	1	0	0	0	0	1	0	0	0	10354	922	32	1	506	1	NEUROG3	10	71332658	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	9499373	71332658	64202089	566	15344										
C10orf54	64115	broad.mit.edu	37	chr10	73521588	73521588	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaggtgaaggtcctggaacGtgaggttgcggatgggccgg	20	7	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:73521588G>A	uc001jsd.2	-	2	419	c.278C>T	c.(277-279)ACG>ATG	p.T93M	CDH23_uc001jrx.3_Intron|C10orf54_uc001jse.2_Translation_Start_Site|C10orf54_uc009xqm.2_Intron|C10orf54_uc001jsf.1_Missense_Mutation_p.T93M	NM_022153	NP_071436	Q9H7M9	GI24_HUMAN	platelet receptor Gi24 precursor	93	Ig-like.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GTCCTGGAACGTGAGGTTGCG	0.652													0	0	0	0.012319	0	20	64										A	73521588	G	A	73521588	3	1	54	1	0	0	0	0	1	0	0	0	1607	1145	40	2	681	2	C10orf54	10	73521588	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2188930	73521588	62013159	567	15345										
KCNMA1	3778	broad.mit.edu	37	chr10	78708987	78708987	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccacaaacacaatgtgcttGagctcatggtaatgaaagtt	8	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:78708987G>C	uc001jxn.2	-	22	2799	c.2622C>G	c.(2620-2622)CTC>CTG	p.L874L	KCNMA1_uc001jxj.2_Silent_p.L820L|KCNMA1_uc001jxk.1_Silent_p.L492L|KCNMA1_uc009xrt.1_Silent_p.L665L|KCNMA1_uc001jxl.1_Silent_p.L499L|KCNMA1_uc001jxo.2_Silent_p.L857L|KCNMA1_uc001jxm.2_Silent_p.L816L|KCNMA1_uc001jxq.2_Silent_p.L819L	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	874	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CAATGTGCTTGAGCTCATGGT	0.527													0	0	0	0.004289	0	31	95										C	78708987	G	C	78708987	2	2	54	1	0	0	0	0	0	0	0	1	8073	1277	45	1		1	KCNMA1	10	78708987	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5187399	78708987	56825760	568	15346										
IFIT2	3433	broad.mit.edu	37	chr10	91066371	91066371	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctcctggctctgaagcttCataagatgcgtgaagaaggt	11	9	2	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:91066371C>T	uc009xts.2	+	2	833	c.658C>T	c.(658-660)CAT>TAT	p.H220Y	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	220					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				TCTGAAGCTTCATAAGATGCG	0.502													0	0	0	0.001984	0	4	39										T	91066371	C	T	91066371	3	4	54	1	0	0	0	0	1	0	0	0	7523	826	29	1	664	1	IFIT2	10	91066371	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	12357384	91066371	44468376	569	15347										
CC2D2B	387707	broad.mit.edu	37	chr10	97772423	97772423	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcttagtcacaagatatatCaaggcattaaatccacctca	4	10	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:97772423C>G	uc001kll.2	+	4	454	c.255C>G	c.(253-255)ATC>ATG	p.I85M	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Missense_Mutation_p.I85M	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	85										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		CAAGATATATCAAGGCATTAA	0.299													0	0	0	0.008291	0	9	26										G	97772423	C	G	97772423	3	3	54	1	0	0	0	0	1	0	0	0	2729	816	29	1	265	1	CC2D2B	10	97772423	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6706052	97772423	37762324	570	15348										
TLL2	7093	broad.mit.edu	37	chr10	98205917	98205917	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctctcagatgcctgctcttCaagcccacctagaggaatgg	10	13	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:98205917C>G	uc001kml.1	-	3	521	c.295G>C	c.(295-297)GAA>CAA	p.E99Q	TLL2_uc009xvf.1_Missense_Mutation_p.E99Q	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	99					cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCCTGCTCTTCAAGCCCACCT	0.557													0	0	0	0.007291	0	29	92										G	98205917	C	G	98205917	3	3	54	1	0	0	0	0	1	0	0	0	15943	835	29	1	2828	1	TLL2	10	98205917	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	433494	98205917	37328830	571	15349										
PI4K2A	55361	broad.mit.edu	37	chr10	99416092	99416092	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tatagtgccattgaccgagtGaagtccaggggcaagcggct	14	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:99416092G>A	uc001kog.1	+	3	744	c.687G>A	c.(685-687)GTG>GTA	p.V229V	PI4K2A_uc010qoy.1_Silent_p.V199V|PI4K2A_uc009xvw.1_5'UTR	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	229	PI3K/PI4K.				phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		TTGACCGAGTGAAGTCCAGGG	0.493													0	0	0	0.003163	0	13	74										A	99416092	G	A	99416092	2	1	54	1	0	0	0	0	0	0	0	1	11871	1277	45	1		1	PI4K2A	10	99416092	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1210175	99416092	36118655	572	15350										
PYROXD2	84795	broad.mit.edu	37	chr10	100174797	100174797	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accaccgcatcatactcaggCttcagacctcccctggcttc	6	18	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:100174797C>T	uc001kpc.2	-	1	182	c.96G>A	c.(94-96)AAG>AAA	p.K32K	PYROXD2_uc001kpd.2_RNA|PYROXD2_uc010qpe.1_Silent_p.K32K	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	32							oxidoreductase activity			central_nervous_system(1)	1						CATACTCAGGCTTCAGACCTC	0.617													0	0	0	0.00361	0	67	249										T	100174797	C	T	100174797	2	4	54	1	0	0	0	0	0	0	0	1	12867	796	28	2		2	PYROXD2	10	100174797	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	758705	100174797	35359950	573	15351										
ENTPD7	57089	broad.mit.edu	37	chr10	101464399	101464399	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cattggacttgctgtggcttGaagaggtggtgcccatgatg	15	7	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:101464399G>A	uc001kqa.3	+	13	1952	c.1774G>A	c.(1774-1776)GAA>AAA	p.E592K	ENTPD7_uc009xwl.2_Missense_Mutation_p.E594K	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	592	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		GCTGTGGCTTGAAGAGGTGGT	0.572													0	0	0	0.003163	0	12	20										A	101464399	G	A	101464399	3	1	54	1	0	0	0	0	1	0	0	0	5144	1291	45	1	1820	1	ENTPD7	10	101464399	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1289602	101464399	34070348	574	15352										
PKD2L1	9033	broad.mit.edu	37	chr10	102058407	102058407	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagaatgtcctcccggaagtCttcatgcaccacacaggagt	9	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:102058407C>G	uc001kqx.1	-	4	1026	c.643G>C	c.(643-645)GAC>CAC	p.D215H	PKD2L1_uc009xwm.1_Missense_Mutation_p.D168H	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	215	Extracellular (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TCCCGGAAGTCTTCATGCACC	0.542													0	0	0	0.00361	0	53	117										G	102058407	C	G	102058407	3	3	54	1	0	0	0	0	1	0	0	0	11967	913	32	1	1826	1	PKD2L1	10	102058407	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	594008	102058407	33476340	575	15353										
CNNM2	54805	broad.mit.edu	37	chr10	104678579	104678579	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagaacatcaataacgagacGtggtcccgcatcgccttcac	8	14	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:104678579G>A	uc001kwm.2	+	1	466	c.342G>A	c.(340-342)ACG>ACA	p.T114T	CNNM2_uc001kwn.2_Silent_p.T114T|CNNM2_uc001kwl.2_Silent_p.T114T	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	114					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATAACGAGACGTGGTCCCGCA	0.547													0	0	0	0.001855	0	10	32										A	104678579	G	A	104678579	2	1	54	1	0	0	0	0	0	0	0	1	3613	1132	40	2		2	CNNM2	10	104678579	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2620172	104678579	30856168	576	15354										
PDCD11	22984	broad.mit.edu	37	chr10	105179396	105179396	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgctgctcattggttttgtGaagagcatcaaggactatgg	12	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:105179396G>A	uc001kwy.1	+	16	2295	c.2208G>A	c.(2206-2208)GTG>GTA	p.V736V		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	736	S1 motif 8.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTGGTTTTGTGAAGAGCATCA	0.498													0	0	0	0.002299	0	19	73										A	105179396	G	A	105179396	2	1	54	1	0	0	0	0	0	0	0	1	11617	1277	45	1		1	PDCD11	10	105179396	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	500817	105179396	30355351	577	15355										
CALHM2	51063	broad.mit.edu	37	chr10	105207266	105207266	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtggtgagcagtaatgcttGaggcacttggtcaggaacac	14	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:105207266G>C	uc001kwz.2	-	3	1001	c.615C>G	c.(613-615)CTC>CTG	p.L205L	CALHM2_uc001kxa.2_Silent_p.L205L|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Silent_p.L205L	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	205	Helical; (Potential).					integral to membrane				skin(1)	1						AGTAATGCTTGAGGCACTTGG	0.617													0	0	0	0.008871	0	18	52										C	105207266	G	C	105207266	2	2	54	1	0	0	0	0	0	0	0	1	2583	1277	45	1		1	CALHM2	10	105207266	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	27870	105207266	30327481	578	15356										
C10orf79	80217	broad.mit.edu	37	chr10	105942240	105942240	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tagtttctggtaatagtccaGaatttcactggctaggtgtc	10	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:105942240G>C	uc001kxw.2	-	17	2289	c.2173C>G	c.(2173-2175)CTG>GTG	p.L725V	C10orf79_uc009xxq.2_Missense_Mutation_p.L33V|C10orf79_uc001kxx.3_Missense_Mutation_p.L726V	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	725											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TAATAGTCCAGAATTTCACTG	0.348													0	0	0	0.00308	0	7	38										C	105942240	G	C	105942240	3	2	54	1	0	0	0	0	1	0	0	0	1618	933	33	1	2912	1	C10orf79	10	105942240	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	734974	105942240	29592507	579	15357										
PDZD8	118987	broad.mit.edu	37	chr10	119044035	119044035	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcatcctaaagccacatcttCaagttttaaactaacatgcc	4	12	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:119044035C>T	uc001lde.1	-	5	2408	c.2209G>A	c.(2209-2211)GAA>AAA	p.E737K		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	737					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		GCCACATCTTCAAGTTTTAAA	0.453													0	0	0	0.004482	0	9	30										T	119044035	C	T	119044035	3	4	54	1	0	0	0	0	1	0	0	0	11705	835	29	1	1259	1	PDZD8	10	119044035	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	13101795	119044035	16490712	580	15358										
FAM175B	23172	broad.mit.edu	37	chr10	126523473	126523473	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taatagtgaatactcacattCaaaggattctcgacccatgg	7	9	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr10:126523473C>T	uc001lib.3	+	9	1226	c.1181C>T	c.(1180-1182)TCA>TTA	p.S394L		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	394						BRISC complex	polyubiquitin binding				0						TACTCACATTCAAAGGATTCT	0.463													0	0	0	0.00499	0	14	47										T	126523473	C	T	126523473	3	4	54	1	0	0	0	0	1	0	0	0	5498	838	29	1	1215	1	FAM175B	10	126523473	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7479438	126523473	9011274	581	15359										
RIC8A	60626	broad.mit.edu	37	chr11	209946	209946	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actgagcgggccatggagatCctcaaagtgctcttcaacat	10	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:209946C>T	uc001log.2	+	3	997	c.672C>T	c.(670-672)ATC>ATT	p.I224I	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Silent_p.I224I|RIC8A_uc001loh.2_Silent_p.I217I	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	224						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCATGGAGATCCTCAAAGTGC	0.577													0	0	0	0.010729	0	11	72										T	209946	C	T	209946	2	4	54	1	0	0	0	0	0	0	0	1	13355	845	30	1		1	RIC8A	11	209946	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08		209946	134796570	582	15360										
MUC5B	727897	broad.mit.edu	37	chr11	1159327	1159327	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccatgcccgggtacctgctCtgtgcttggaggtgcccact	12	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:1159327C>T	uc009ycr.1	+	12	1430	c.1304C>T	c.(1303-1305)TCT>TTT	p.S435F		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	426	VWFD 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTACCTGCTCTGTGCTTGGA	0.637													0	0	0	0.010504	0	19	105										T	1159327	C	T	1159327	3	4	54	1	0	0	0	0	1	0	0	0	9979	928	32	1		1	MUC5B	11	1159327	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	949381	1159327	133847189	583	15361										
MUC5B	727897	broad.mit.edu	37	chr11	1272547	1272547	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggccacaccctcctccactCtggggacgacccggatcctc	9	20	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:1272547C>T	uc009ycr.1	+	52	15529	c.15403C>T	c.(15403-15405)CTG>TTG	p.L5135L	MUC5B_uc001ltb.2_Silent_p.L4816L	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4758	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCTCCACTCTGGGGACGAC	0.627													0	0	0	0.002299	0	20	130										T	1272547	C	T	1272547	2	4	54	1	0	0	0	0	0	0	0	1	9979	912	32	1		1	MUC5B	11	1272547	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	113220	1272547	133733969	584	15362										
TOLLIP	54472	broad.mit.edu	37	chr11	1298324	1298324	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggcggcatccttgttccctCgctgggcttccagcacggag	13	14	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:1298324C>T	uc001lte.2	-	6	881	c.770G>A	c.(769-771)CGA>CAA	p.R257Q	TOLLIP_uc001ltd.2_Missense_Mutation_p.R188Q|TOLLIP_uc009ycu.2_Missense_Mutation_p.R196Q|TOLLIP_uc001ltf.2_Missense_Mutation_p.R207Q	NM_019009	NP_061882	Q9H0E2	TOLIP_HUMAN	toll interacting protein	257	CUE.				cell-cell signaling|inflammatory response|innate immune response|intracellular signal transduction|leukocyte activation|phosphorylation	cytosol|interleukin-1 receptor complex|interleukin-18 receptor complex	kinase binding|signal transducer activity|Toll-like receptor binding				0		all_cancers(49;7.62e-05)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.00152)|Lung(200;0.09)|LUSC - Lung squamous cell carcinoma(625;0.107)		CTTGTTCCCTCGCTGGGCTTC	0.627													0	0	0	0.009535	0	24	163										T	1298324	C	T	1298324	3	4	54	1	0	0	0	0	1	0	0	0	16347	884	31	1	58	1	TOLLIP	11	1298324	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	25777	1298324	133708192	585	15363										
SYT9	143425	broad.mit.edu	37	chr11	7334658	7334658	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgaagacaactcaacttgtCaaacccggacttcaatatcc	5	14	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:7334658C>T	uc001mfe.2	+	3	767	c.530C>T	c.(529-531)TCA>TTA	p.S177L	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	177	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CTCAACTTGTCAAACCCGGAC	0.378													0	0	0	0.000602	0	3	33										T	7334658	C	T	7334658	3	4	54	1	0	0	0	0	1	0	0	0	15478	838	29	1	540	1	SYT9	11	7334658	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6036334	7334658	127671858	586	15364										
PPFIBP2	8495	broad.mit.edu	37	chr11	7647116	7647116	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccacagtgagagtcacacaGagagaggtgactagcttgac	12	9	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:7647116G>C	uc001mfj.3	+	8	1208	c.820G>C	c.(820-822)GAG>CAG	p.E274Q	PPFIBP2_uc010rbb.1_Missense_Mutation_p.E197Q|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.E197Q|PPFIBP2_uc010rbd.1_Missense_Mutation_p.E116Q|PPFIBP2_uc010rbe.1_Missense_Mutation_p.E162Q|PPFIBP2_uc001mfl.3_Missense_Mutation_p.E131Q	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	274	Potential.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GAGTCACACAGAGAGAGGTGA	0.507													0	0	0	0.009096	0	3	38										C	7647116	G	C	7647116	3	2	54	1	0	0	0	0	1	0	0	0	12314	943	33	1	846	1	PPFIBP2	11	7647116	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	312458	7647116	127359400	587	15365										
NLRP10	338322	broad.mit.edu	37	chr11	7982410	7982410	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcctctgcagctcatcaaagCcatccaggatgaacaggagc	10	13	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:7982410C>T	uc001mfv.1	-	2	766	c.749G>A	c.(748-750)GGC>GAC	p.G250D		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	250	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTCATCAAAGCCATCCAGGAT	0.527													0	0	0	0.001168	0	4	51										T	7982410	C	T	7982410	3	4	54	1	0	0	0	0	1	0	0	0	10472	739	26	2	1222	2	NLRP10	11	7982410	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	335294	7982410	127024106	588	15366										
SCUBE2	57758	broad.mit.edu	37	chr11	9051467	9051467	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtttgtggagccatcaaagtCagtcgtagtatttcctgggc	12	8	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:9051467C>T	uc001mhh.1	-	18	2460	c.2380G>A	c.(2380-2382)GAC>AAC	p.D794N	SCUBE2_uc001mhi.1_Missense_Mutation_p.D766N|SCUBE2_uc001mhj.1_Missense_Mutation_p.D668N	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	794						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		CCATCAAAGTCAGTCGTAGTA	0.448													0	0	0	0.00632	0	22	156										T	9051467	C	T	9051467	3	4	54	1	0	0	0	0	1	0	0	0	13945	826	29	1	639	1	SCUBE2	11	9051467	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1069057	9051467	125955049	589	15367										
AMPD3	272	broad.mit.edu	37	chr11	10500089	10500089	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttagaaagaaaagtttcaagAtgattcggtcccagtccctg	9	8	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:10500089A>G	uc001mio.1	+	3	573	c.238A>G	c.(238-240)ATG>GTG	p.M80V	AMPD3_uc010rbz.1_Intron|AMPD3_uc001min.1_Missense_Mutation_p.M89V|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Missense_Mutation_p.M80V|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.M87V|AMPD3_uc009yfy.2_Missense_Mutation_p.M80V	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	80					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		AAGTTTCAAGATGATTCGGTC	0.532													0	0	0	0.00361	0	88	232										G	10500089	A	G	10500089	3	3	54	1	0	0	0	0	1	0	0	0	587	333	12	5	295	5	AMPD3	11	10500089	Missense_Mutation	SNP	A	TCGA-DK-A2I4-01A-11D-A21A-08	1448622	10500089	124506427	590	15368										
EIF4G2	1982	broad.mit.edu	37	chr11	10823911	10823911	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attttcatcctgggtggcatGaacggtccctccagaaagaa	10	10	1	3	rs142114099		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:10823911G>A	uc001mjc.2	-	12	1485	c.1068C>T	c.(1066-1068)TTC>TTT	p.F356F	EIF4G2_uc001mjb.2_Silent_p.F150F|EIF4G2_uc009ygf.2_Silent_p.F150F|EIF4G2_uc001mjd.2_Silent_p.F356F|EIF4G2_uc001mjf.1_Silent_p.F150F|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	356					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TGGGTGGCATGAACGGTCCCT	0.428													0	0	0	0.00278	0	21	130										A	10823911	G	A	10823911	2	1	54	1	0	0	0	0	0	0	0	1	5037	1281	45	1		1	EIF4G2	11	10823911	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	323822	10823911	124182605	591	15369										
SPON1	10418	broad.mit.edu	37	chr11	14280896	14280896	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctcctgcggcatgggcatGaggtcccgggagaggtatgt	16	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:14280896G>A	uc001mle.2	+	13	2101	c.1563G>A	c.(1561-1563)ATG>ATA	p.M521I		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	521	TSP type-1 2.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		GCATGGGCATGAGGTCCCGGG	0.627													0	0	0	0.008291	0	7	46										A	14280896	G	A	14280896	3	1	54	1	0	0	0	0	1	0	0	0	15081	1290	45	1	1608	1	SPON1	11	14280896	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3456985	14280896	120725620	592	15370										
SPON1	10418	broad.mit.edu	37	chr11	14280908	14280908	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgggcatgaggtcccgggaGaggtatgtgaagcagttccc	16	8	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:14280908G>A	uc001mle.2	+	13	2113	c.1575G>A	c.(1573-1575)GAG>GAA	p.E525E		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	525	TSP type-1 2.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		GGTCCCGGGAGAGGTATGTGA	0.632													0	0	0	0.010729	0	7	46										A	14280908	G	A	14280908	2	1	54	1	0	0	0	0	0	0	0	1	15081	933	33	1		1	SPON1	11	14280908	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	12	14280908	120725608	593	15371										
SPON1	10418	broad.mit.edu	37	chr11	14282247	14282247	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtctctggcagaacttggaGactgcaatgaggatctggag	14	7	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:14282247G>C	uc001mle.2	+	15	2483	c.1945G>C	c.(1945-1947)GAC>CAC	p.D649H		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	649	TSP type-1 4.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		AGAACTTGGAGACTGCAATGA	0.577													0	0	0	0.003954	0	20	76										C	14282247	G	C	14282247	3	2	54	1	0	0	0	0	1	0	0	0	15081	942	33	1	1998	1	SPON1	11	14282247	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1339	14282247	120724269	594	15372										
COPB1	1315	broad.mit.edu	37	chr11	14487843	14487843	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcacctagtgtagctagttCtaatgtgcaattctgcaaag	8	9	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:14487843C>G	uc001mli.2	-	17	2582	c.2275G>C	c.(2275-2277)GAA>CAA	p.E759Q	COPB1_uc001mlg.2_Missense_Mutation_p.E759Q|COPB1_uc001mlh.2_Missense_Mutation_p.E759Q	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	759					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2						GTAGCTAGTTCTAATGTGCAA	0.383													0	0	0	0.004656	0	22	96										G	14487843	C	G	14487843	3	3	54	1	0	0	0	0	1	0	0	0	3728	922	32	1	610	1	COPB1	11	14487843	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	205596	14487843	120518673	595	15373										
TPH1	7166	broad.mit.edu	37	chr11	18057567	18057567	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaacattggtatgagacttCagcagatgaaaaatatcatt	8	5	2	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:18057567C>T	uc001mnp.2	-	2	266	c.240G>A	c.(238-240)CTG>CTA	p.L80L	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	80	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TATGAGACTTCAGCAGATGAA	0.318													0	0	0	0.00308	0	7	32										T	18057567	C	T	18057567	2	4	54	1	0	0	0	0	0	0	0	1	16398	813	29	1		1	TPH1	11	18057567	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3569724	18057567	116948949	596	15374										
LRP4	4038	broad.mit.edu	37	chr11	46917828	46917828	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accccgttgcacagcttcctCtgcccaatgcagcgcccatt	7	18	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:46917828C>T	uc001ndn.3	-	9	1127	c.981G>A	c.(979-981)CAG>CAA	p.Q327Q		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	327	Extracellular (Potential).|LDL-receptor class A 8.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		ACAGCTTCCTCTGCCCAATGC	0.597													0	0	0	0.00333	0	23	122										T	46917828	C	T	46917828	2	4	54	1	0	0	0	0	0	0	0	1	8959	912	32	1		1	LRP4	11	46917828	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	28860261	46917828	88088688	597	15375										
MTCH2	23788	broad.mit.edu	37	chr11	47660529	47660529	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggcacttaccataactaaaGagaccaggaagctgacacac	8	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:47660529G>C	uc010rho.1	-	2	351	c.162C>G	c.(160-162)CTC>CTG	p.L54L	MTCH2_uc001nge.2_5'UTR|MTCH2_uc010rhp.1_5'UTR	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	54	Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0						CATAACTAAAGAGACCAGGAA	0.383													0	0	0	0.00499	0	13	43										C	47660529	G	C	47660529	2	2	54	1	0	0	0	0	0	0	0	1	9914	929	33	1		1	MTCH2	11	47660529	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	742701	47660529	87345987	598	15376										
SSRP1	6749	broad.mit.edu	37	chr11	57100260	57100260	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtcagacactgcagctcccGgaagatgcagatggcatctc	11	12	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:57100260G>A	uc001njt.2	-	6	874	c.607C>T	c.(607-609)CGG>TGG	p.R203W	SSRP1_uc010rjq.1_Missense_Mutation_p.R203W	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	203					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						TGCAGCTCCCGGAAGATGCAG	0.527													0	0	0	0.001984	0	5	71										A	57100260	G	A	57100260	3	1	54	1	0	0	0	0	1	0	0	0	15193	1115	39	2	1570	2	SSRP1	11	57100260	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9439731	57100260	77906256	599	15377										
MS4A1	931	broad.mit.edu	37	chr11	60233575	60233575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgtgaaccagctaatccctCtgagaaaaactccccatcta	5	14	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:60233575C>T	uc001npp.2	+	6	934	c.518C>T	c.(517-519)TCT>TTT	p.S173F	MS4A1_uc001npq.2_Missense_Mutation_p.S173F|MS4A1_uc009yna.2_Missense_Mutation_p.S173F|MS4A1_uc009ymz.2_Missense_Mutation_p.S173F|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	173	Epitope 3 (recognized by antibodies, including Rituximab).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	GCTAATCCCTCTGAGAAAAAC	0.358													0	0	0	0.009535	0	29	72										T	60233575	C	T	60233575	3	4	54	1	0	0	0	0	1	0	0	0	9854	913	32	1	532	1	MS4A1	11	60233575	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3133315	60233575	74772941	600	15378										
VWCE	220001	broad.mit.edu	37	chr11	61026481	61026481	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggggtcgaaggccctggtGagagtcgaggggaggcccca	20	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:61026481G>A	uc001nra.2	-	20	2813	c.2534C>T	c.(2533-2535)TCA>TTA	p.S845L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	845	Pro-rich.					extracellular region	calcium ion binding			ovary(1)	1						AGGCCCTGGTGAGAGTCGAGG	0.642													0	0	0	0.010729	0	10	32										A	61026481	G	A	61026481	3	1	54	1	0	0	0	0	1	0	0	0	17242	1294	45	1	337	1	VWCE	11	61026481	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	792906	61026481	73980035	601	15379										
C11orf66	220004	broad.mit.edu	37	chr11	61252187	61252187	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggtccatttcgacacccagGagcacgggcctcaggccatc	11	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:61252187G>C	uc001nru.1	+	5	534	c.409G>C	c.(409-411)GAG>CAG	p.E137Q	C11orf66_uc009ynq.1_Missense_Mutation_p.E137Q	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	137										ovary(1)	1						CGACACCCAGGAGCACGGGCC	0.537													0	0	0	0.004482	0	5	30										C	61252187	G	C	61252187	3	2	54	1	0	0	0	0	1	0	0	0	1656	1175	41	1	423	1	C11orf66	11	61252187	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	225706	61252187	73754329	602	15380										
C11orf9	745	broad.mit.edu	37	chr11	61545871	61545871	+	Silent	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtgtcatcgctcaggaggtGaaggagatcttgcctgaggc							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:61545871G>A	uc001nsc.1	+	14	2019	c.1923G>A	c.(1921-1923)GTG>GTA	p.V641V	C11orf9_uc001nse.1_Silent_p.V632V|C11orf9_uc010rll.1_Silent_p.V32V	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	641					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CTCAGGAGGTGAAGGAGATCT	0.537													0	0	0	0.004656	0	22	182										A	61545871	G	A	61545871	2	1	54	1	0	0	0	0	0	0	0	1	1671	1277	45	1		1	C11orf9	11	61545871	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	293684	61545871	73460645	603	15381	74	2								
C11orf9	745	broad.mit.edu	37	chr11	61545877	61545877	+	Silent	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcgctcaggaggtgaaggaGatcttgcctgaggctgtgaa							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:61545877G>A	uc001nsc.1	+	14	2025	c.1929G>A	c.(1927-1929)GAG>GAA	p.E643E	C11orf9_uc001nse.1_Silent_p.E634E|C11orf9_uc010rll.1_Silent_p.E34E	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	643					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						AGGTGAAGGAGATCTTGCCTG	0.547													0	0	0	0.007291	0	24	182										A	61545877	G	A	61545877	2	1	54	1	0	0	0	0	0	0	0	1	1671	933	33	1		1	C11orf9	11	61545877	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6	61545877	73460639	604	15382	74	2								
NXF1	10482	broad.mit.edu	37	chr11	62569489	62569489	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtactggcgtcttcaacgaaGaactgggcccgtgtattctc	11	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:62569489G>C	uc001nvf.1	-	5	619	c.483C>G	c.(481-483)TTC>TTG	p.F161L	NXF1_uc001nvg.1_Missense_Mutation_p.F161L|NXF1_uc009yog.1_Missense_Mutation_p.F204L|NXF1_uc010rmh.1_Missense_Mutation_p.F24L	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	161	Interaction with THOC4.|RRM.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						CTTCAACGAAGAACTGGGCCC	0.522													0	0	0	0.00278	0	17	105										C	62569489	G	C	62569489	3	2	54	1	0	0	0	0	1	0	0	0	10782	933	33	1	1499	1	NXF1	11	62569489	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1023612	62569489	72437027	605	15383										
NXF1	10482	broad.mit.edu	37	chr11	62570909	62570909	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actgtaatcttgaaccagttCtttgaggtcccatcctggct	8	11	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:62570909C>T	uc001nvf.1	-	3	487	c.351G>A	c.(349-351)AAG>AAA	p.K117K	NXF1_uc001nvg.1_Silent_p.K117K|NXF1_uc009yog.1_Silent_p.K160K|NXF1_uc010rmh.1_Intron	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	117	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TGAACCAGTTCTTTGAGGTCC	0.473													0	0	0	0.007291	0	25	185										T	62570909	C	T	62570909	2	4	54	1	0	0	0	0	0	0	0	1	10782	912	32	1		1	NXF1	11	62570909	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1420	62570909	72435607	606	15384										
STX5	6811	broad.mit.edu	37	chr11	62575050	62575050	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaagtacttgaggatctctGaatgggcggcctcaacgtcc	13	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:62575050G>C	uc001nvh.2	-	11	1113	c.959C>G	c.(958-960)TCA>TGA	p.S320*	NXF1_uc001nvf.1_5'Flank|NXF1_uc001nvg.1_5'Flank|NXF1_uc009yog.1_5'Flank|NXF1_uc010rmh.1_5'Flank|STX5_uc010rmi.1_Nonsense_Mutation_p.S224*|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Nonsense_Mutation_p.S266*|STX5_uc010rmj.1_3'UTR|STX5_uc001nvj.2_Nonsense_Mutation_p.S135*	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	320	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						GAGGATCTCTGAATGGGCGGC	0.507													0	0	0	0.010729	0	11	32										C	62575050	G	C	62575050	4	2	54	1	0	0	0	0	0	1	0	0	15347	1294	45	1	112	1	STX5	11	62575050	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4141	62575050	72431466	607	15385										
SLC22A10	387775	broad.mit.edu	37	chr11	63072312	63072312	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttattgtcttcctcctaccaGaaaccaagaatctgcctttg	5	12	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:63072312G>A	uc009yor.2	+	9	1757	c.1549G>A	c.(1549-1551)GAA>AAA	p.E517K	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_3'UTR	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	517	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CCTCCTACCAGAAACCAAGAA	0.433													0	0	0	0.001855	0	12	55										A	63072312	G	A	63072312	3	1	54	1	0	0	0	0	1	0	0	0	14441	943	33	1	1583	1	SLC22A10	11	63072312	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	497262	63072312	71934204	608	15386										
RTN3	10313	broad.mit.edu	37	chr11	63486675	63486675	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgtctccatccaaagtttCaggagatgatgttattgaaa	8	6	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:63486675C>T	uc001nxq.2	+	3	888	c.701C>T	c.(700-702)TCA>TTA	p.S234L	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.S215L|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.S122L|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	234					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						TCCAAAGTTTCAGGAGATGAT	0.373													0	0	0	0.007413	0	13	44										T	63486675	C	T	63486675	3	4	54	1	0	0	0	0	1	0	0	0	13727	838	29	1	711	1	RTN3	11	63486675	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	414363	63486675	71519841	609	15387										
RTN3	10313	broad.mit.edu	37	chr11	63486765	63486765	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgacaaagaatttaaagactCatataaggagagcacagatg	9	5	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:63486765C>G	uc001nxq.2	+	3	978	c.791C>G	c.(790-792)TCA>TGA	p.S264*	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Nonsense_Mutation_p.S245*|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Nonsense_Mutation_p.S152*|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	264					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						TTTAAAGACTCATATAAGGAG	0.368													0	0	0	0.006122	0	16	28										G	63486765	C	G	63486765	4	3	54	1	0	0	0	0	0	1	0	0	13727	838	29	1	801	1	RTN3	11	63486765	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	90	63486765	71519751	610	15388										
ESRRA	2101	broad.mit.edu	37	chr11	64082560	64082560	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctgggtgtggcccagcgctCactgccactgcaggatgagc	15	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:64082560C>G	uc001nzq.1	+	6	1007	c.830C>G	c.(829-831)TCA>TGA	p.S277*	ESRRA_uc001nzr.1_Nonsense_Mutation_p.S276*|ESRRA_uc001nzs.1_Nonsense_Mutation_p.S277*|ESRRA_uc009ypn.1_RNA	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	277	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						GCCCAGCGCTCACTGCCACTG	0.647													0	0	0	0.006122	0	13	71										G	64082560	C	G	64082560	4	3	54	1	0	0	0	0	0	1	0	0	5260	838	29	1	848	1	ESRRA	11	64082560	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	595795	64082560	70923956	611	15389										
RASGRP2	10235	broad.mit.edu	37	chr11	64508453	64508453	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgattaggctgctgtgccgtCggttcccttcttggtctagc	12	12	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:64508453C>T	uc009ypu.2	-	5	565	c.338G>A	c.(337-339)CGA>CAA	p.R113Q	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'UTR|RASGRP2_uc009ypv.2_Missense_Mutation_p.R113Q|RASGRP2_uc009ypw.2_Missense_Mutation_p.R113Q	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	113	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						GCTGTGCCGTCGGTTCCCTTC	0.557											OREG0004006	type=REGULATORY REGION|Gene=RASGRP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.00245	0	12	66										T	64508453	C	T	64508453	3	4	54	1	0	0	0	0	1	0	0	0	13075	884	31	1	1539	1	RASGRP2	11	64508453	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	425893	64508453	70498063	612	15390										
PPP2R5B	5526	broad.mit.edu	37	chr11	64694350	64694350	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcacccggggtgtcctcatCgagcccgtctacccagacat	10	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:64694350C>T	uc001oby.2	+	3	951	c.366C>T	c.(364-366)ATC>ATT	p.I122I	PPP2R5B_uc001obz.2_Silent_p.I122I	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	122					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						GTGTCCTCATCGAGCCCGTCT	0.662													0	0	0	0.008291	0	10	76										T	64694350	C	T	64694350	2	4	54	1	0	0	0	0	0	0	0	1	12393	874	31	1		1	PPP2R5B	11	64694350	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	185897	64694350	70312166	613	15391										
SNX15	29907	broad.mit.edu	37	chr11	64795031	64795031	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtcccgccaggcgaaggatGacttcctgcggcactacaca	11	14	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:64795031G>A	uc001oci.3	+	4	675	c.22G>A	c.(22-24)GAC>AAC	p.D8N	SNX15_uc009ypy.2_Missense_Mutation_p.D8N|SNX15_uc001ocj.2_Missense_Mutation_p.D8N|SNX15_uc001ock.2_Missense_Mutation_p.D8N	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	8	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						GGCGAAGGATGACTTCCTGCG	0.692											OREG0021069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006999	0	35	236										A	64795031	G	A	64795031	3	1	54	1	0	0	0	0	1	0	0	0	14886	1290	45	1	24	1	SNX15	11	64795031	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	100681	64795031	70211485	614	15392										
SIPA1	6494	broad.mit.edu	37	chr11	65417656	65417656	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctaagggaactccaaaatctGatgctgagtaagctccccaa	8	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:65417656G>A	uc001ofb.2	+	14	3063	c.2896G>A	c.(2896-2898)GAT>AAT	p.D966N	SIPA1_uc010rom.1_Missense_Mutation_p.D864N|SIPA1_uc001ofd.2_Missense_Mutation_p.D966N	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	966					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						TCCAAAATCTGATGCTGAGTA	0.602													0	0	0	0.007835	0	34	113										A	65417656	G	A	65417656	3	1	54	1	0	0	0	0	1	0	0	0	14328	1290	45	1	2946	1	SIPA1	11	65417656	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	622625	65417656	69588860	615	15393										
KDM2A	22992	broad.mit.edu	37	chr11	67021043	67021043	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagtaggaatcaaggaccctCaaattcgggacttgcttact	9	10	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:67021043C>G	uc001ojw.2	+	19	3916	c.3052C>G	c.(3052-3054)CAA>GAA	p.Q1018E	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Missense_Mutation_p.Q712E|KDM2A_uc001ojz.1_Missense_Mutation_p.Q476E|KDM2A_uc001oka.2_Missense_Mutation_p.Q142E	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	1018					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						CAAGGACCCTCAAATTCGGGA	0.552													0	0	0	0.006122	0	17	81										G	67021043	C	G	67021043	3	3	54	1	0	0	0	0	1	0	0	0	8124	827	29	1	3122	1	KDM2A	11	67021043	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1603387	67021043	67985473	616	15394										
SUV420H1	51111	broad.mit.edu	37	chr11	67925239	67925239	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttttccaactattaacctCaagcgcttagctggaggaag	8	10	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:67925239C>G	uc001onm.1	-	11	2830	c.2574G>C	c.(2572-2574)TTG>TTC	p.L858F	SUV420H1_uc009yse.1_Missense_Mutation_p.L444F|SUV420H1_uc001onn.1_Missense_Mutation_p.L686F|SUV420H1_uc009ysf.2_Missense_Mutation_p.L618F	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	858					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CTATTAACCTCAAGCGCTTAG	0.403													0	0	0	0.001984	0	7	20										G	67925239	C	G	67925239	3	3	54	1	0	0	0	0	1	0	0	0	15411	825	29	1	87	1	SUV420H1	11	67925239	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	904196	67925239	67081277	617	15395										
SUV420H1	51111	broad.mit.edu	37	chr11	67925604	67925604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tattttggaagagttcattcCatcattctcttggtcatttg	7	7	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:67925604C>T	uc001onm.1	-	11	2465	c.2209G>A	c.(2209-2211)GGA>AGA	p.G737R	SUV420H1_uc009yse.1_Missense_Mutation_p.G323R|SUV420H1_uc001onn.1_Missense_Mutation_p.G565R|SUV420H1_uc009ysf.2_Missense_Mutation_p.G497R	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	737					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GAGTTCATTCCATCATTCTCT	0.373													0	0	0	0.006122	0	17	190										T	67925604	C	T	67925604	3	4	54	1	0	0	0	0	1	0	0	0	15411	603	21	2	452	2	SUV420H1	11	67925604	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	365	67925604	67080912	618	15396										
SUV420H1	51111	broad.mit.edu	37	chr11	67925754	67925754	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttttgcagttctaaagctgtCttttgttttgaagctatctg	8	6	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:67925754C>A	uc001onm.1	-	11	2315	c.2059G>T	c.(2059-2061)GAC>TAC	p.D687Y	SUV420H1_uc009yse.1_Missense_Mutation_p.D273Y|SUV420H1_uc001onn.1_Missense_Mutation_p.D515Y|SUV420H1_uc009ysf.2_Missense_Mutation_p.D447Y	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	687					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CTAAAGCTGTCTTTTGTTTTG	0.443													1	0	1.02788e-11	0.00499	1.09461e-11	16	33										A	67925754	C	A	67925754	3	1	54	1	0	0	0	0	1	0	0	0	15411	913	32	3	602	3	SUV420H1	11	67925754	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	150	67925754	67080762	619	15397										
MRGPRD	116512	broad.mit.edu	37	chr11	68748225	68748225	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgagcgtggaagccatgctGaagaggaagaggaggtcggc	18	7	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:68748225G>A	uc010rqf.1	-	1	231	c.231C>T	c.(229-231)TTC>TTT	p.F77F		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	77	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AAGCCATGCTGAAGAGGAAGA	0.552													0	0	0	0.008361	0	24	69										A	68748225	G	A	68748225	2	1	54	1	0	0	0	0	0	0	0	1	9763	1281	45	1		1	MRGPRD	11	68748225	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	822471	68748225	66258291	620	15398										
NUMA1	4926	broad.mit.edu	37	chr11	71725723	71725723	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctgtctgtctcctgccctCgcaggctccttgactaactc	9	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:71725723C>T	uc001orl.1	-	15	2998	c.2826G>A	c.(2824-2826)GCG>GCA	p.A942A	NUMA1_uc009ysw.1_Silent_p.A505A|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Silent_p.A942A|NUMA1_uc001orn.2_Silent_p.A505A|NUMA1_uc009ysx.1_Silent_p.A942A|NUMA1_uc001oro.1_Silent_p.A942A	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	942	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTCCTGCCCTCGCAGGCTCCT	0.642			T	RARA	APL								0	0	0	0.007291	0	25	95										T	71725723	C	T	71725723	2	4	54	1	0	0	0	0	0	0	0	1	10750	871	31	1		1	NUMA1	11	71725723	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2977498	71725723	63280793	621	15399										
FOLR2	2350	broad.mit.edu	37	chr11	71932542	71932542	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagtgcccagctggggctctCtgccgcacctttgagtccta	11	14	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:71932542C>T	uc009ytd.2	+	5	673	c.504C>T	c.(502-504)CTC>CTT	p.L168L	FOLR2_uc009yte.2_Silent_p.L168L|FOLR2_uc001ose.3_Silent_p.L168L|FOLR2_uc009ytf.2_Silent_p.L168L	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	168					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)	CTGGGGCTCTCTGCCGCACCT	0.597													0	0	0	0.00361	0	38	316										T	71932542	C	T	71932542	2	4	54	1	0	0	0	0	0	0	0	1	5982	900	32	1		1	FOLR2	11	71932542	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	206819	71932542	63073974	622	15400										
PPME1	51400	broad.mit.edu	37	chr11	73882471	73882471	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgcagcctcccctcgatgtCggccctcgaaaagagcatgc	11	15	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:73882471C>G	uc001ouw.2	+	1	104	c.5C>G	c.(4-6)TCG>TGG	p.S2W	C2CD3_uc001ouu.2_5'Flank|C2CD3_uc001ouv.2_5'Flank	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	2					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					CCCTCGATGTCGGCCCTCGAA	0.642													0	0	0	0.00308	0	8	35										G	73882471	C	G	73882471	3	3	54	1	0	0	0	0	1	0	0	0	12347	893	31	1	7	1	PPME1	11	73882471	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1949929	73882471	61124045	623	15401										
CHRDL2	25884	broad.mit.edu	37	chr11	74419417	74419417	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctggttcggggcaggttgtGaggccgcagtagatctggcc	17	10	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:74419417G>C	uc001ovi.2	-	5	709	c.456C>G	c.(454-456)CTC>CTG	p.L152L	CHRDL2_uc001ovg.2_Silent_p.L36L|CHRDL2_uc001ovh.2_Silent_p.L152L|CHRDL2_uc001ovk.1_Silent_p.L152L			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	152	VWFC 2.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					GGCAGGTTGTGAGGCCGCAGT	0.622													0	0	0	0.00308	0	5	36										C	74419417	G	C	74419417	2	2	54	1	0	0	0	0	0	0	0	1	3374	1277	45	1		1	CHRDL2	11	74419417	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	536946	74419417	60587099	624	15402										
XRRA1	143570	broad.mit.edu	37	chr11	74651851	74651851	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcctccggcacgcgaagcaGatttctggctgggaagcagt	13	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:74651851G>A	uc009yub.2	-	3	405	c.73C>T	c.(73-75)CTG>TTG	p.L25L	XRRA1_uc001ovm.2_Intron|XRRA1_uc001ovo.2_Intron|XRRA1_uc001ovq.3_Silent_p.L25L|XRRA1_uc001ovp.3_Intron|XRRA1_uc001ovr.2_Intron	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	25					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						ACGCGAAGCAGATTTCTGGCT	0.498													0	0	0	0.001168	0	4	14										A	74651851	G	A	74651851	2	1	54	1	0	0	0	0	0	0	0	1	17458	933	33	1		1	XRRA1	11	74651851	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	232434	74651851	60354665	625	15403										
PCF11	51585	broad.mit.edu	37	chr11	82879595	82879595	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcgccggcctggatacaaatCagcgacttacagctttagct	9	12	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:82879595C>T	uc001ozx.3	+	8	2563	c.2218C>T	c.(2218-2220)CAG>TAG	p.Q740*	PCF11_uc010rsu.1_Nonsense_Mutation_p.Q871*	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	740	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GGATACAAATCAGCGACTTAC	0.433													0	0	0	0.00333	0	18	67										T	82879595	C	T	82879595	4	4	54	1	0	0	0	0	0	1	0	0	11573	827	29	1	2248	1	PCF11	11	82879595	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	8227744	82879595	52126921	626	15404										
DLG2	1740	broad.mit.edu	37	chr11	83195224	83195224	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccttgttcttgtagaatggGaattttcgtgaaaagatgaa	10	4	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:83195224G>A	uc001paj.2	-	17	2229	c.1926C>T	c.(1924-1926)TTC>TTT	p.F642F	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Intron|DLG2_uc010rsz.1_Intron|DLG2_uc010rta.1_Intron|DLG2_uc001pak.2_Silent_p.F747F|DLG2_uc010rtb.1_Silent_p.F609F|DLG2_uc010rsw.1_Intron|DLG2_uc010rsx.1_Intron	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	642						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TGTAGAATGGGAATTTTCGTG	0.398													0	0	0	0.004482	0	4	33										A	83195224	G	A	83195224	2	1	54	1	0	0	0	0	0	0	0	1	4555	1165	41	1		1	DLG2	11	83195224	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	315629	83195224	51811292	627	15405										
PANX1	24145	broad.mit.edu	37	chr11	93912933	93912933	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgggctattacttcagcctCtcctcactctcagacgagtt	7	14	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:93912933C>T	uc001per.2	+	4	1096	c.711C>T	c.(709-711)CTC>CTT	p.L237L	PANX1_uc001peq.2_Silent_p.L237L	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	237	Helical; (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ACTTCAGCCTCTCCTCACTCT	0.453													0	0	0	0.010729	0	12	49										T	93912933	C	T	93912933	2	4	54	1	0	0	0	0	0	0	0	1	11420	900	32	1		1	PANX1	11	93912933	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10717709	93912933	41093583	628	15406										
AMOTL1	154810	broad.mit.edu	37	chr11	94533394	94533394	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggatgctccacgagatggtCaagccctaccctgctcctca	10	15	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:94533394C>G	uc001pfb.2	+	3	1208	c.1038C>G	c.(1036-1038)GTC>GTG	p.V346V	AMOTL1_uc001pfc.2_Silent_p.V296V	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	346						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				ACGAGATGGTCAAGCCCTACC	0.567													0	0	0	0.003755	0	31	201										G	94533394	C	G	94533394	2	3	54	1	0	0	0	0	0	0	0	1	583	813	29	1		1	AMOTL1	11	94533394	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	620461	94533394	40473122	629	15407										
KIAA1377	57562	broad.mit.edu	37	chr11	101828992	101828992	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcaattgtgagaaagaaatGaatgaaaacatgagggcaac	10	4	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:101828992G>C	uc001pgm.2	+	5	870	c.600G>C	c.(598-600)ATG>ATC	p.M200I	KIAA1377_uc001pgn.2_Missense_Mutation_p.M156I|KIAA1377_uc010run.1_Missense_Mutation_p.M1I|KIAA1377_uc009yxa.1_Missense_Mutation_p.M1I	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	200							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AGAAAGAAATGAATGAAAACA	0.378													0	0	0	0.004007	0	16	117										C	101828992	G	C	101828992	3	2	54	1	0	0	0	0	1	0	0	0	8227	1290	45	1	618	1	KIAA1377	11	101828992	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7295598	101828992	33177524	630	15408										
TMEM123	114908	broad.mit.edu	37	chr11	102272700	102272700	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tattgtgggttacggtcattGtggatgttgatatctgagat	13	3	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:102272700G>A	uc001pha.2	-	3	816	c.395C>T	c.(394-396)ACA>ATA	p.T132I	TMEM123_uc009yxc.2_Missense_Mutation_p.T113I	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	132	Thr-rich.|Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		TACGGTCATTGTGGATGTTGA	0.388													0	0	0	0.010504	0	16	140										A	102272700	G	A	102272700	3	1	54	1	0	0	0	0	1	0	0	0	16033	1377	48	2	243	2	TMEM123	11	102272700	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	443708	102272700	32733816	631	15409										
MMP20	9313	broad.mit.edu	37	chr11	102479695	102479695	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcctggatccctttcacatCatctttggggaggtggaatc	11	10	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:102479695C>T	uc001phc.2	-	5	797	c.784G>A	c.(784-786)GAT>AAT	p.D262N		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	262					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CCTTTCACATCATCTTTGGGG	0.468													0	0	0	0.00499	0	11	119										T	102479695	C	T	102479695	3	4	54	1	0	0	0	0	1	0	0	0	9659	826	29	1	691	1	MMP20	11	102479695	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	206995	102479695	32526821	632	15410										
CASP4	837	broad.mit.edu	37	chr11	104821781	104821781	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aactctgtattgcatatgatGagagccaggcgtgtgcggtt	13	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:104821781G>A	uc001pid.1	-	4	490	c.417C>T	c.(415-417)CTC>CTT	p.L139L	CASP4_uc001pib.1_Silent_p.L83L|CASP4_uc009yxg.1_Silent_p.L48L|CASP4_uc010rux.1_Silent_p.L139L	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	139					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		TGCATATGATGAGAGCCAGGC	0.453													0	0	0	0.001984	0	5	38										A	104821781	G	A	104821781	2	1	54	1	0	0	0	0	0	0	0	1	2673	1277	45	1		1	CASP4	11	104821781	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2342086	104821781	30184735	633	15411										
VPS11	55823	broad.mit.edu	37	chr11	118948904	118948904	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccaactctgaggagttcatcCccatctttgccaataacccg	6	15	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:118948904C>T	uc010ryx.1	+	12	1825	c.1783C>T	c.(1783-1785)CCC>TCC	p.P595S	VPS11_uc010ryy.1_Missense_Mutation_p.P441S	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	595					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GGAGTTCATCCCCATCTTTGC	0.527													0	0	0	0.00632	0	23	260										T	118948904	C	T	118948904	3	4	54	1	0	0	0	0	1	0	0	0	17185	623	22	2	1824	2	VPS11	11	118948904	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	14127123	118948904	16057612	634	15412										
MFRP	83552	broad.mit.edu	37	chr11	119212284	119212284	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgggcacaagcttccaggtCagctgcctctggcagcctgt	12	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:119212284C>T	uc001pwj.2	-	13	1874	c.1714G>A	c.(1714-1716)GAC>AAC	p.D572N	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.D454N	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GCTTCCAGGTCAGCTGCCTCT	0.662													0	0	0	0.001368	0	9	54										T	119212284	C	T	119212284	3	4	54	1	0	0	0	0	1	0	0	0	9526	826	29	1	29	1	MFRP	11	119212284	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	263380	119212284	15794232	635	15413										
TECTA	7007	broad.mit.edu	37	chr11	120996548	120996548	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtgccaagcccttggcattCcaattggagactggcgaacc	11	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:120996548C>A	uc010rzo.1	+	7	1741	c.1741C>A	c.(1741-1743)CCA>ACA	p.P581T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	581					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCTTGGCATTCCAATTGGAGA	0.592													1	0	2.0095e-06	0.001984	2.09856e-06	6	52										A	120996548	C	A	120996548	3	1	54	1	0	0	0	0	1	0	0	0	15744	855	30	3	1767	3	TECTA	11	120996548	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1784264	120996548	14009968	636	15414										
C11orf63	79864	broad.mit.edu	37	chr11	122805215	122805215	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgacatggtgaatgaccatCaaccttccagaagaccagcc	8	13	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:122805215C>G	uc001pym.2	+	5	1363	c.1066C>G	c.(1066-1068)CAA>GAA	p.Q356E		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	356										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GAATGACCATCAACCTTCCAG	0.448													0	0	0	0.004482	0	6	24										G	122805215	C	G	122805215	3	3	54	1	0	0	0	0	1	0	0	0	1654	827	29	1	1144	1	C11orf63	11	122805215	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1808667	122805215	12201301	637	15415										
ESAM	90952	broad.mit.edu	37	chr11	124623758	124623758	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggagggccatggggtggccgGagggctcgtgcggaggtgac	23	8	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr11:124623758G>A	uc001qav.3	-	7	1130	c.957C>T	c.(955-957)CTC>CTT	p.L319L	VSIG2_uc001qas.2_5'Flank|VSIG2_uc001qat.2_5'Flank|ESAM_uc010sao.1_Intron|ESAM_uc001qau.3_Silent_p.L246L|ESAM_uc001qaw.3_RNA|ESAM_uc001qax.3_RNA|ESAM_uc009zbi.2_Missense_Mutation_p.S318F	NM_138961	NP_620411	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule precursor	319	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction					0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		GGGGTGGCCGGAGGGCTCGTG	0.662													0	0	0	0.00308	0	6	64										A	124623758	G	A	124623758	2	1	54	1	0	0	0	0	0	0	0	1	5247	1161	41	1		1	ESAM	11	124623758	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1818543	124623758	10382758	638	15416										
CACNA2D4	93589	broad.mit.edu	37	chr12	2017150	2017150	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aactcggcgcccagctccacGaagttgcccttctcgtccct	8	18	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:2017150G>A	uc001qjp.2	-	5	771	c.540C>T	c.(538-540)TTC>TTT	p.F180F	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.F180F	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	180	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CCAGCTCCACGAAGTTGCCCT	0.627													0	0	0	0.008871	0	18	100										A	2017150	G	A	2017150	2	1	54	1	0	0	0	0	0	0	0	1	2551	1049	37	1		1	CACNA2D4	12	2017150	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		2017150	131834745	639	15417										
TEAD4	7004	broad.mit.edu	37	chr12	3104006	3104006	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccctgaggggagcaccgcctCtgggggcagtcaggcactgg	17	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:3104006C>T	uc010sej.1	+	3	348	c.71C>T	c.(70-72)TCT>TTT	p.S24F	TEAD4_uc010sek.1_Missense_Mutation_p.S24F|TEAD4_uc001qln.2_Intron	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	25					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			AGCACCGCCTCTGGGGGCAGT	0.647													0	0	0	0.004289	0	27	202										T	3104006	C	T	3104006	3	4	54	1	0	0	0	0	1	0	0	0	15738	913	32	1	76	1	TEAD4	12	3104006	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1086856	3104006	130747889	640	15418										
EFCAB4B	84766	broad.mit.edu	37	chr12	3789434	3789434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgaactcctgtggggtcaGatagccattgccatcagcat	11	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:3789434G>C	uc001qmj.2	-	5	882	c.310C>G	c.(310-312)CTG>GTG	p.L104V	EFCAB4B_uc010sen.1_Missense_Mutation_p.L104V|EFCAB4B_uc010seo.1_Missense_Mutation_p.L104V	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	104	EF-hand 2.|				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TGTGGGGTCAGATAGCCATTG	0.512													0	0	0	0.010504	0	15	97										C	3789434	G	C	3789434	3	2	54	1	0	0	0	0	1	0	0	0	4937	933	33	1	2141	1	EFCAB4B	12	3789434	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	685428	3789434	130062461	641	15419										
CHD4	1108	broad.mit.edu	37	chr12	6692090	6692090	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccgcaggcccttacgactgGgcctacggggagctgcaaga	14	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:6692090G>A	uc001qpo.2	-	28	4324	c.4160C>T	c.(4159-4161)CCC>CTC	p.P1387L	CHD4_uc001qpn.2_Missense_Mutation_p.P1380L|CHD4_uc001qpp.2_Missense_Mutation_p.P1412L|uc001qpq.1_Missense_Mutation_p.G98E|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1387					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTTACGACTGGGCCTACGGGG	0.448													0	0	0	0.006122	0	18	89										A	6692090	G	A	6692090	3	1	54	1	0	0	0	0	1	0	0	0	3327	1232	43	2	1630	2	CHD4	12	6692090	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2902656	6692090	127159805	642	15420										
CD163L1	283316	broad.mit.edu	37	chr12	7527246	7527246	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacaccacgtgggcatcgctCaggtcccagccgtcatcaca	9	17	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:7527246C>G	uc001qsy.2	-	13	3227	c.3201G>C	c.(3199-3201)CTG>CTC	p.L1067L	CD163L1_uc010sge.1_Silent_p.L1077L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1067	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GGGCATCGCTCAGGTCCCAGC	0.622											OREG0021653	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	13	81										G	7527246	C	G	7527246	2	3	54	1	0	0	0	0	0	0	0	1	2968	813	29	1		1	CD163L1	12	7527246	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	835156	7527246	126324649	643	15421										
RIMKLB	57494	broad.mit.edu	37	chr12	8866535	8866535	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggaagactatcctcaaaaaGagattttacgagcattgaag	10	6	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:8866535G>A	uc001quu.2	+	2	324	c.73G>A	c.(73-75)GAG>AAG	p.E25K	RIMKLB_uc009zgf.1_RNA|RIMKLB_uc001qux.2_Missense_Mutation_p.E25K|RIMKLB_uc010sgl.1_Missense_Mutation_p.E25K|RIMKLB_uc001quw.2_Missense_Mutation_p.E25K	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	25					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						TCCTCAAAAAGAGATTTTACG	0.478													0	0	0	0.006214	0	7	39										A	8866535	G	A	8866535	3	1	54	1	0	0	0	0	1	0	0	0	13366	943	33	1	75	1	RIMKLB	12	8866535	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1339289	8866535	124985360	644	15422										
CLEC1B	51266	broad.mit.edu	37	chr12	10149469	10149469	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgttccggttgtcaatcttCaggagagtagcattcatgtc	10	8	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:10149469C>A	uc001qwu.2	-	4	614	c.414G>T	c.(412-414)CTG>CTT	p.L138L	CLEC1B_uc009zhd.2_Silent_p.L105L	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	138	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						TGTCAATCTTCAGGAGAGTAG	0.398													1	0	3.86212e-05	0.008291	3.98512e-05	9	74										A	10149469	C	A	10149469	2	1	54	1	0	0	0	0	0	0	0	1	3506	813	29	3		3	CLEC1B	12	10149469	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1282934	10149469	123702426	645	15423										
WBP11	51729	broad.mit.edu	37	chr12	14946788	14946788	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actgtcatcatgcttatcttGatccatgtcctcaggatagc	7	11	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:14946788G>C	uc001rci.2	-	8	951	c.790C>G	c.(790-792)CAA>GAA	p.Q264E		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	264	Asp-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						TGCTTATCTTGATCCATGTCC	0.463													0	0	0	0.00499	0	15	136										C	14946788	G	C	14946788	3	2	54	1	0	0	0	0	1	0	0	0	17255	1299	45	1	1155	1	WBP11	12	14946788	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4797319	14946788	118905107	646	15424										
AEBP2	121536	broad.mit.edu	37	chr12	19593295	19593295	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acccctgagccgcatggactCggaggacaggtcagtgctct	13	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:19593295C>A	uc001ref.2	+	1	688	c.662C>A	c.(661-663)TCG>TAG	p.S221*	AEBP2_uc001ree.2_Nonsense_Mutation_p.S221*|AEBP2_uc001reg.1_5'Flank	NM_001114176	NP_001107648	Q6ZN18	AEBP2_HUMAN	AE binding protein 2 isoform b	221	Ser-rich.|Interaction with RBBP4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					CGCATGGACTCGGAGGACAGG	0.562													1	0	8.12818e-05	0.001984	8.37371e-05	5	68										A	19593295	C	A	19593295	4	1	54	1	0	0	0	0	0	1	0	0	350	893	31	3	664	3	AEBP2	12	19593295	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4646507	19593295	114258600	647	15425										
SLCO1B1	10599	broad.mit.edu	37	chr12	21392055	21392055	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgtcatggatgaagcaaacTtagaatccttaaataaaaat	7	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:21392055T>A	uc001req.3	+	15	2112	c.2008T>A	c.(2008-2010)TTA>ATA	p.L670I		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	670	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGAAGCAAACTTAGAATCCTT	0.318													0	0	0	0.009096	0	3	13										A	21392055	T	A	21392055	3	1	54	1	0	0	0	0	1	0	0	0	14723	1606	56	5	2062	5	SLCO1B1	12	21392055	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	1798760	21392055	112459840	648	15426										
ITPR2	3709	broad.mit.edu	37	chr12	26589263	26589263	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagatgtgcctcgagaaccaGaacagtgcagggttatctag	13	8	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:26589263G>A	uc001rhg.2	-	48	7077	c.6660C>T	c.(6658-6660)TTC>TTT	p.F2220F	ITPR2_uc009zjg.1_Silent_p.F371F	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2220	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCGAGAACCAGAACAGTGCAG	0.418													0	0	0	0.000602	0	4	45										A	26589263	G	A	26589263	2	1	54	1	0	0	0	0	0	0	0	1	7921	933	33	1		1	ITPR2	12	26589263	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5197208	26589263	107262632	649	15427										
ARNTL2	56938	broad.mit.edu	37	chr12	27523108	27523108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaaaagctttctcagaatCcccttacctatcttctttca	4	12	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:27523108C>T	uc001rht.1	+	3	247	c.229C>T	c.(229-231)CCC>TCC	p.P77S	ARNTL2_uc001rhw.2_Intron|ARNTL2_uc010sjp.1_Intron|ARNTL2_uc001rhu.1_Missense_Mutation_p.P77S|ARNTL2_uc009zji.1_Intron|ARNTL2_uc001rhv.1_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	77					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					TTCTCAGAATCCCCTTACCTA	0.483													0	0	0	0.007413	0	14	91										T	27523108	C	T	27523108	3	4	54	1	0	0	0	0	1	0	0	0	968	855	30	1	239	1	ARNTL2	12	27523108	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	933845	27523108	106328787	650	15428										
BICD1	636	broad.mit.edu	37	chr12	32480797	32480797	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgagcaggtgacaagccttGagaagaccaccaaggagagt	13	8	0	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:32480797G>C	uc001rku.2	+	5	1489	c.1408G>C	c.(1408-1410)GAG>CAG	p.E470Q	BICD1_uc001rkv.2_Missense_Mutation_p.E470Q|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	470	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			GACAAGCCTTGAGAAGACCAC	0.418													0	0	0	0.004672	0	3	40										C	32480797	G	C	32480797	3	2	54	1	0	0	0	0	1	0	0	0	1428	1291	45	1	1426	1	BICD1	12	32480797	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4957689	32480797	101371098	651	15429										
ARID2	196528	broad.mit.edu	37	chr12	46245498	46245498	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgcaactcagctcattgctCcagcaggaattaccatgagc	8	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:46245498C>G	uc001ros.1	+	15	3592	c.3592C>G	c.(3592-3594)CCA>GCA	p.P1198A	ARID2_uc001ror.2_Missense_Mutation_p.P1198A|ARID2_uc009zkg.1_Missense_Mutation_p.P654A|ARID2_uc009zkh.1_Missense_Mutation_p.P825A|ARID2_uc001rou.1_Missense_Mutation_p.P532A	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1198					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GCTCATTGCTCCAGCAGGAAT	0.498													0	0	0	0.000602	0	5	51										G	46245498	C	G	46245498	3	3	54	1	0	0	0	0	1	0	0	0	915	855	30	1	3650	1	ARID2	12	46245498	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	13764701	46245498	87606397	652	15430										
H1FNT	341567	broad.mit.edu	37	chr12	48723735	48723735	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acgaggggcgaggacaggccGtgaaggaagacaccacgccg	17	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:48723735G>A	uc001rrm.2	+	1	973	c.661G>A	c.(661-663)GTG>ATG	p.V221M		NM_181788	NP_861453	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	221					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			pancreas(1)	1						AGGACAGGCCGTGAAGGAAGA	0.662													0	0	0	0.009096	0	4	16										A	48723735	G	A	48723735	3	1	54	1	0	0	0	0	1	0	0	0	6921	1145	40	2	663	2	H1FNT	12	48723735	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2478237	48723735	85128160	653	15431										
TUBA1A	7846	broad.mit.edu	37	chr12	49579554	49579554	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtctaccatgaaggcacaatCagagtgctccagggtggtgt	13	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:49579554C>T	uc009zlf.2	-	4	867	c.595G>A	c.(595-597)GAT>AAT	p.D199N	TUBA1B_uc001rto.2_Intron|TUBA1A_uc001rtp.2_Missense_Mutation_p.D199N|TUBA1A_uc001rtq.2_Missense_Mutation_p.D46N|TUBA1A_uc001rtr.2_Missense_Mutation_p.D46N|TUBA1A_uc009zlg.2_Missense_Mutation_p.D46N	NM_006009	NP_006000	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	199					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity				0						AAGGCACAATCAGAGTGCTCC	0.498													0	0	0	0.001855	0	12	103										T	49579554	C	T	49579554	3	4	54	1	0	0	0	0	1	0	0	0	16740	826	29	1	764	1	TUBA1A	12	49579554	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	855819	49579554	84272341	654	15432										
KCNH3	23416	broad.mit.edu	37	chr12	49934725	49934725	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcccaggtggcggggctcttCcccgtggtctactgctctga	14	14	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:49934725C>T	uc001ruh.1	+	2	380	c.120C>T	c.(118-120)TTC>TTT	p.F40F	KCNH3_uc010smj.1_5'UTR	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	40	Cytoplasmic (Potential).|PAS.				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CGGGGCTCTTCCCCGTGGTCT	0.632													0	0	0	0.001368	0	9	72										T	49934725	C	T	49934725	2	4	54	1	0	0	0	0	0	0	0	1	8033	854	30	1		1	KCNH3	12	49934725	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	355171	49934725	83917170	655	15433										
KCNH3	23416	broad.mit.edu	37	chr12	49935417	49935417	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgtttttgtgcccagggctCccgttctggtgtctcctgga	12	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:49935417C>A	uc001ruh.1	+	3	575	c.315C>A	c.(313-315)CTC>CTA	p.L105L	KCNH3_uc010smj.1_Silent_p.L45L	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	105	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GCCCAGGGCTCCCGTTCTGGT	0.547													1	0	2.35188e-11	0.006122	2.50044e-11	16	151										A	49935417	C	A	49935417	2	1	54	1	0	0	0	0	0	0	0	1	8033	842	30	3		3	KCNH3	12	49935417	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	692	49935417	83916478	656	15434										
LIMA1	51474	broad.mit.edu	37	chr12	50616148	50616148	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtctgctctgtgcctaatctCagtgctgctgttccgtagag	11	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:50616148C>A	uc001rwj.3	-	4	460	c.286G>T	c.(286-288)GAG>TAG	p.E96*	LIMA1_uc001rwh.3_5'UTR|LIMA1_uc001rwi.3_5'UTR|LIMA1_uc001rwk.3_Nonsense_Mutation_p.E96*|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	96					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TGCCTAATCTCAGTGCTGCTG	0.527													1	0	4.96729e-08	0.008871	5.21686e-08	16	173										A	50616148	C	A	50616148	4	1	54	1	0	0	0	0	0	1	0	0	8796	835	29	3	2028	3	LIMA1	12	50616148	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	680731	50616148	83235747	657	15435										
KRT6B	3854	broad.mit.edu	37	chr12	52845454	52845454	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actctggttgacagtgacctCttggatgcctccaggggggc	14	11	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:52845454C>G	uc001sak.2	-	1	457	c.409G>C	c.(409-411)GAG>CAG	p.E137Q		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	137	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		ACAGTGACCTCTTGGATGCCT	0.642													0	0	0	0.003163	0	12	176										G	52845454	C	G	52845454	3	3	54	1	0	0	0	0	1	0	0	0	8481	922	32	1	1321	1	KRT6B	12	52845454	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2229306	52845454	81006441	658	15436										
KRT6A	3853	broad.mit.edu	37	chr12	52886480	52886480	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttgagggtcttgatctgttCacgctcctcagcccgcaccc	10	15	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:52886480C>T	uc001sam.2	-	1	702	c.493G>A	c.(493-495)GAA>AAA	p.E165K		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	165	Coil 1A.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		TTGATCTGTTCACGCTCCTCA	0.592													0	0	0	0.00361	0	41	290										T	52886480	C	T	52886480	3	4	54	1	0	0	0	0	1	0	0	0	8480	835	29	1	1237	1	KRT6A	12	52886480	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	41026	52886480	80965415	659	15437										
RARG	5916	broad.mit.edu	37	chr12	53607028	53607028	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcctccaggtccatgcggtCtatggggacaagtatactgg	12	11	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:53607028C>T	uc001sce.2	-	9	1504	c.1019_splice	c.e9-1	p.D340_splice	RARG_uc001scd.2_Splice_Site_p.D329_splice|RARG_uc010sob.1_Splice_Site_p.D318_splice|RARG_uc001scf.2_Splice_Site_p.D340_splice|RARG_uc001scg.2_Splice_Site_p.D268_splice|RARG_uc010soc.1_Splice_Site_p.D219_splice|RARG_uc010sod.1_3'UTR	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1						canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TCCATGCGGTCTATGGGGACA	0.607											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	7	64										T	53607028	C	T	53607028	5	4	54	1	0	0	0	0	0	0	1	0	13054	927	32	1	354	1	RARG	12	53607028	Splice_Site	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	720548	53607028	80244867	660	15438										
TARBP2	6895	broad.mit.edu	37	chr12	53897505	53897505	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccctcgggaagttctttttCtcccctagactcttcactgc	6	16	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:53897505C>T	uc001sdo.2	+	4	823	c.335C>T	c.(334-336)TCT>TTT	p.S112F	TARBP2_uc009znb.2_Missense_Mutation_p.S112F|TARBP2_uc001sdp.2_Missense_Mutation_p.S91F|TARBP2_uc001sdq.2_5'UTR|TARBP2_uc001sdr.2_Intron|TARBP2_uc001sds.2_Missense_Mutation_p.S112F|TARBP2_uc001sdt.2_Missense_Mutation_p.S91F|TARBP2_uc001sdu.2_Intron|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	112					miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						AGTTCTTTTTCTCCCCTAGAC	0.562													0	0	0	0.001368	0	10	106										T	53897505	C	T	53897505	3	4	54	1	0	0	0	0	1	0	0	0	15553	913	32	1	349	1	TARBP2	12	53897505	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	290477	53897505	79954390	661	15439										
NPFF	8620	broad.mit.edu	37	chr12	53900643	53900643	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcccggggactcagccattCattcctccaggatccctggg	11	15	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:53900643C>T	uc001sdw.1	-	3	423	c.259G>A	c.(259-261)GAA>AAA	p.E87K		NM_003717	NP_003708	O15130	NPFF_HUMAN	neuropeptide FF-amide peptide preproprotein	87					neuropeptide signaling pathway|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0						CTCAGCCATTCATTCCTCCAG	0.552													0	0	0	0.005524	0	31	195										T	53900643	C	T	53900643	3	4	54	1	0	0	0	0	1	0	0	0	10576	835	29	1	86	1	NPFF	12	53900643	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3138	53900643	79951252	662	15440										
ITGA5	3678	broad.mit.edu	37	chr12	54795249	54795249	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tactgggaatagcactgcctCaggcttggagacactaagga	12	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:54795249C>T	uc001sga.2	-	24	2469	c.2401G>A	c.(2401-2403)GAG>AAG	p.E801K		NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	801	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						AGCACTGCCTCAGGCTTGGAG	0.567													0	0	0	0.00632	0	27	183										T	54795249	C	T	54795249	3	4	54	1	0	0	0	0	1	0	0	0	7879	835	29	1	776	1	ITGA5	12	54795249	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	894606	54795249	79056646	663	15441										
OR6C3	254786	broad.mit.edu	37	chr12	55726281	55726281	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctgcaaaagaaaaggcatCattgacaaaaggaatagcta	8	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:55726281C>T	uc010spj.1	+	1	797	c.797C>T	c.(796-798)TCA>TTA	p.S266L		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAAAAGGCATCATTGACAAAA	0.383													0	0	0	0.009096	0	4	34										T	55726281	C	T	55726281	3	4	54	1	0	0	0	0	1	0	0	0	11192	838	29	1	799	1	OR6C3	12	55726281	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	931032	55726281	78125614	664	15442										
COQ10A	93058	broad.mit.edu	37	chr12	56663988	56663988	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctggccaccatgttttttGatgaggttgtcaaacagaat	10	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:56663988G>C	uc001sko.3	+	5	892	c.631G>C	c.(631-633)GAT>CAT	p.D211H	COQ10A_uc001skp.3_Missense_Mutation_p.D179H|COQ10A_uc001skq.3_Missense_Mutation_p.D194H	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	211						mitochondrial inner membrane				ovary(1)	1						CATGTTTTTTGATGAGGTTGT	0.493													0	0	0	0.003271	0	27	204										C	56663988	G	C	56663988	3	2	54	1	0	0	0	0	1	0	0	0	3743	1290	45	1	691	1	COQ10A	12	56663988	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	937707	56663988	77187907	665	15443										
TIMELESS	8914	broad.mit.edu	37	chr12	56816720	56816720	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccacaaaggctttttggttGactgcagccagtgcaaaaaa	9	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:56816720G>C	uc001slf.2	-	19	2517	c.2349C>G	c.(2347-2349)GTC>GTG	p.V783V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	783					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CTTTTTGGTTGACTGCAGCCA	0.493													0	0	0	0.00308	0	6	85										C	56816720	G	C	56816720	2	2	54	1	0	0	0	0	0	0	0	1	15901	1277	45	1		1	TIMELESS	12	56816720	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	152732	56816720	77035175	666	15444										
TIMELESS	8914	broad.mit.edu	37	chr12	56817142	56817142	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaagtagggcttccattttGaggtcatgggccagccggtg	14	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:56817142G>C	uc001slf.2	-	18	2376	c.2208C>G	c.(2206-2208)CTC>CTG	p.L736L		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	736					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CTTCCATTTTGAGGTCATGGG	0.507													0	0	0	0.001984	0	6	109										C	56817142	G	C	56817142	2	2	54	1	0	0	0	0	0	0	0	1	15901	1277	45	1		1	TIMELESS	12	56817142	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	422	56817142	77034753	667	15445										
TIMELESS	8914	broad.mit.edu	37	chr12	56817207	56817207	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgtgggcactattctgctGgtagctccttagtagcagca	12	9	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:56817207G>C	uc001slf.2	-	18	2311	c.2143C>G	c.(2143-2145)CAG>GAG	p.Q715E		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	715					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CTATTCTGCTGGTAGCTCCTT	0.488													0	0	0	0.000602	0	5	103										C	56817207	G	C	56817207	3	2	54	1	0	0	0	0	1	0	0	0	15901	1357	47	4	1531	4	TIMELESS	12	56817207	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	65	56817207	77034688	668	15446										
TIMELESS	8914	broad.mit.edu	37	chr12	56827390	56827390	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaagctgggctccttaggcaGattgccaaaacagagcaagg	12	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:56827390G>A	uc001slf.2	-	4	466	c.298C>T	c.(298-300)CTG>TTG	p.L100L	TIMELESS_uc001slg.2_Silent_p.L100L	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	100					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TCCTTAGGCAGATTGCCAAAA	0.483													0	0	0	0.00245	0	14	80										A	56827390	G	A	56827390	2	1	54	1	0	0	0	0	0	0	0	1	15901	933	33	1		1	TIMELESS	12	56827390	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10183	56827390	77024505	669	15447										
STAT6	6778	broad.mit.edu	37	chr12	57501056	57501056	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctccttgaagtatttgtctGaaagtggccaccagcttcag	9	10	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:57501056G>C	uc009zpe.2	-	4	548	c.297C>G	c.(295-297)TTC>TTG	p.F99L	STAT6_uc009zpf.2_Missense_Mutation_p.F99L|STAT6_uc001sna.2_Missense_Mutation_p.F99L|STAT6_uc010srb.1_5'UTR|STAT6_uc010src.1_5'UTR|STAT6_uc010srd.1_5'UTR|STAT6_uc009zpg.2_Missense_Mutation_p.F148L	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	99					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						GTATTTGTCTGAAAGTGGCCA	0.478													0	0	0	0.00499	0	14	107										C	57501056	G	C	57501056	3	2	54	1	0	0	0	0	1	0	0	0	15269	1281	45	1	2322	1	STAT6	12	57501056	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	673666	57501056	76350839	670	15448										
LRP1	4035	broad.mit.edu	37	chr12	57586683	57586683	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgccaggacctgtgtctgctCactcaccagggccatgtcaa	10	14	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:57586683C>T	uc001snd.2	+	45	7951	c.7485C>T	c.(7483-7485)CTC>CTT	p.L2495L	MIR1228_hsa-mir-1228|MI0006318_5'Flank	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2495	EGF-like 10.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGTGTCTGCTCACTCACCAGG	0.647													0	0	0	0.00874	0	40	323										T	57586683	C	T	57586683	2	4	54	1	0	0	0	0	0	0	0	1	8951	813	29	1		1	LRP1	12	57586683	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	85627	57586683	76265212	671	15449										
R3HDM2	22864	broad.mit.edu	37	chr12	57677750	57677750	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agccatcagagtctgtgctgCtccaagggcgtggctccagg	14	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:57677750C>T	uc009zpm.1	-	11	1021	c.986G>A	c.(985-987)AGC>AAC	p.S329N	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_5'UTR|R3HDM2_uc001snr.2_Missense_Mutation_p.S56N|R3HDM2_uc001sns.2_Missense_Mutation_p.S329N|R3HDM2_uc001snt.2_Missense_Mutation_p.S343N	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	329	Ser-rich.					nucleus	nucleic acid binding			ovary(2)	2						GTCTGTGCTGCTCCAAGGGCG	0.597													0	0	0	0.004482	0	9	47										T	57677750	C	T	57677750	3	4	54	1	0	0	0	0	1	0	0	0	12888	797	28	2	1992	2	R3HDM2	12	57677750	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	91067	57677750	76174145	672	15450										
GLI1	2735	broad.mit.edu	37	chr12	57865639	57865639	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtatgtaaccccctggactCtcttgatcttgacaacactc	7	13	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:57865639C>T	uc001snx.2	+	12	3194	c.3116C>T	c.(3115-3117)TCT>TTT	p.S1039F	GLI1_uc009zpq.2_Missense_Mutation_p.S911F	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	1039	Asp/Glu-rich (acidic).				epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CCCCTGGACTCTCTTGATCTT	0.592													0	0	0	0.00361	0	42	251										T	57865639	C	T	57865639	3	4	54	1	0	0	0	0	1	0	0	0	6437	913	32	1	3158	1	GLI1	12	57865639	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	187889	57865639	75986256	673	15451										
GEFT	115557	broad.mit.edu	37	chr12	58010154	58010154	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcctggagtggggagccctgGaagaattcagcttggagatc	16	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:58010154G>T	uc001spb.2	+	14	1968	c.1508G>T	c.(1507-1509)GGA>GTA	p.G503V	GEFT_uc009zpy.2_Missense_Mutation_p.G542V|GEFT_uc001spa.2_Missense_Mutation_p.G397V|uc001spc.2_Intron|GEFT_uc001spd.2_Missense_Mutation_p.G208V	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	503					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					GGGAGCCCTGGAAGAATTCAG	0.607													1	0	4.75885e-15	0.00499	5.1013e-15	17	77										T	58010154	G	T	58010154	3	4	54	1	0	0	0	0	1	0	0	0	6328	1174	41	3	1784	3	GEFT	12	58010154	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	144515	58010154	75841741	674	15452										
XPOT	11260	broad.mit.edu	37	chr12	64812872	64812872	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgatgtggtgcatacatcaGaggcaagtaactaaccatga	11	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:64812872G>C	uc001ssb.2	+	6	913	c.487G>C	c.(487-489)GAG>CAG	p.E163Q	XPOT_uc009zqm.1_Missense_Mutation_p.E73Q	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	163	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GCATACATCAGAGGCAAGTAA	0.393													0	0	0	0.001368	0	11	91										C	64812872	G	C	64812872	3	2	54	1	0	0	0	0	1	0	0	0	17447	943	33	1	505	1	XPOT	12	64812872	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6802718	64812872	69039023	675	15453										
XPOT	11260	broad.mit.edu	37	chr12	64833030	64833030	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttttaatcttcagggcccaGaatgtgttcagtatcttcaa	7	9	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:64833030G>A	uc001ssb.2	+	23	3166	c.2740G>A	c.(2740-2742)GAA>AAA	p.E914K		NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	914	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TCAGGGCCCAGAATGTGTTCA	0.323													0	0	0	0.008291	0	7	59										A	64833030	G	A	64833030	3	1	54	1	0	0	0	0	1	0	0	0	17447	943	33	1	2826	1	XPOT	12	64833030	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	20158	64833030	69018865	676	15454										
HELB	92797	broad.mit.edu	37	chr12	66703693	66703693	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtcaaatcatatgtcatttCatgctgcttcagagtctctg	7	9	6	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:66703693C>T	uc001sti.2	+	4	1013	c.985C>T	c.(985-987)CAT>TAT	p.H329Y	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	329					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TATGTCATTTCATGCTGCTTC	0.383													0	0	0	0.008291	0	10	69										T	66703693	C	T	66703693	3	4	54	1	0	0	0	0	1	0	0	0	7045	826	29	1	999	1	HELB	12	66703693	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1870663	66703693	67148202	677	15455										
NAV3	89795	broad.mit.edu	37	chr12	78513293	78513293	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctgccattggcgggaagtCaaatgcagggagaaaaacca	13	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:78513293C>T	uc001syp.2	+	15	3490	c.3317C>T	c.(3316-3318)TCA>TTA	p.S1106L	NAV3_uc001syo.2_Missense_Mutation_p.S1106L|NAV3_uc010sub.1_Missense_Mutation_p.S606L|NAV3_uc009zsf.2_Missense_Mutation_p.S114L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1106	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGCGGGAAGTCAAATGCAGGG	0.483										HNSCC(70;0.22)			0	0	0	0.003163	0	13	67										T	78513293	C	T	78513293	3	4	54	1	0	0	0	0	1	0	0	0	10185	838	29	1	3375	1	NAV3	12	78513293	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11809600	78513293	55338602	678	15456										
ACSS3	79611	broad.mit.edu	37	chr12	81472105	81472105	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caagacccacttcgcagcctCggtgaccgaccccgagaggt	11	16	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:81472105C>A	uc001szl.1	+	1	297	c.206C>A	c.(205-207)TCG>TAG	p.S69*	ACSS3_uc001szm.1_Nonsense_Mutation_p.S69*	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	69						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TTCGCAGCCTCGGTGACCGAC	0.657													1	0	0.000442599	0.006214	0.000454164	9	90										A	81472105	C	A	81472105	4	1	54	1	0	0	0	0	0	1	0	0	190	893	31	3	208	3	ACSS3	12	81472105	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2958812	81472105	52379790	679	15457										
MYBPC1	4604	broad.mit.edu	37	chr12	102057224	102057224	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgtaacaagccctcctactCttctgactgtggactctgtc	7	14	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:102057224C>T	uc001tii.2	+	20	2269	c.2167C>T	c.(2167-2169)CTT>TTT	p.L723F	MYBPC1_uc001tig.2_Missense_Mutation_p.L748F|MYBPC1_uc010svq.1_Missense_Mutation_p.L710F|MYBPC1_uc001tih.2_Missense_Mutation_p.L748F|MYBPC1_uc001tij.2_Missense_Mutation_p.L723F|MYBPC1_uc010svr.1_Missense_Mutation_p.L723F|MYBPC1_uc010svs.1_Missense_Mutation_p.L723F|MYBPC1_uc010svt.1_Missense_Mutation_p.L711F|MYBPC1_uc010svu.1_Missense_Mutation_p.L704F|MYBPC1_uc001tik.2_Missense_Mutation_p.L697F|MYBPC1_uc001til.2_5'Flank|MYBPC1_uc001tim.2_5'Flank	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	723	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CCCTCCTACTCTTCTGACTGT	0.458													0	0	0	0.004007	0	14	96										T	102057224	C	T	102057224	3	4	54	1	0	0	0	0	1	0	0	0	10011	913	32	1	2328	1	MYBPC1	12	102057224	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	20585119	102057224	31794671	680	15458										
SART3	9733	broad.mit.edu	37	chr12	108954849	108954849	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtcctagccgccttaacctCatcctcctctccgtcagcct	5	19	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:108954849C>T	uc001tmz.1	-	1	317	c.82G>A	c.(82-84)GAG>AAG	p.E28K	SART3_uc009zux.1_5'UTR|SART3_uc010swx.1_Missense_Mutation_p.E28K|SART3_uc010swz.1_Missense_Mutation_p.E28K|SART3_uc001tna.1_RNA|SART3_uc001tnb.2_Missense_Mutation_p.E28K|ISCU_uc010sxa.1_5'Flank|ISCU_uc010sxb.1_5'Flank|ISCU_uc001tnc.3_5'Flank|ISCU_uc010sxc.1_5'Flank|ISCU_uc009zuy.2_5'Flank|ISCU_uc010sxd.1_5'Flank	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	28	Potential.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						GCCTTAACCTCATCCTCCTCT	0.612									Porokeratosis				0	0	0	0.00499	0	13	103										T	108954849	C	T	108954849	3	4	54	1	0	0	0	0	1	0	0	0	13847	835	29	1	2885	1	SART3	12	108954849	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6897625	108954849	24897046	681	15459										
CUX2	23316	broad.mit.edu	37	chr12	111758298	111758298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgcctggccccgcggggacGaggcccctgtgccccccgag	16	19	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:111758298G>A	uc001tsa.1	+	17	2638	c.2485G>A	c.(2485-2487)GAG>AAG	p.E829K		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	829						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CCGCGGGGACGAGGCCCCTGT	0.771													0	0	0	0.000602	0	4	19										A	111758298	G	A	111758298	3	1	54	1	0	0	0	0	1	0	0	0	4065	1059	37	1	2551	1	CUX2	12	111758298	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2803449	111758298	22093597	682	15460										
ATXN2	6311	broad.mit.edu	37	chr12	111957800	111957800	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagctttgtactgggcacttGactcaatttcttctgctaac	8	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:111957800G>C	uc001tsj.2	-	8	1511	c.1349C>G	c.(1348-1350)TCA>TGA	p.S450*	ATXN2_uc001tsh.2_Nonsense_Mutation_p.S185*|ATXN2_uc001tsi.2_Nonsense_Mutation_p.S161*|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Nonsense_Mutation_p.S185*	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	450					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CTGGGCACTTGACTCAATTTC	0.428													0	0	0	0.009096	0	4	45										C	111957800	G	C	111957800	4	2	54	1	0	0	0	0	0	1	0	0	1211	1294	45	1	2664	1	ATXN2	12	111957800	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	199502	111957800	21894095	683	15461										
C12orf51	283450	broad.mit.edu	37	chr12	112707527	112707527	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgatggcaaggcagacttCcttctgaatttcagggcaaa	10	10	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:112707527C>T	uc009zwc.2	-	6	1024	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K	C12orf51_uc010syk.1_Missense_Mutation_p.E159K|C12orf51_uc001tts.2_Missense_Mutation_p.E159K|C12orf51_uc001ttt.3_Missense_Mutation_p.E159K	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						AGGCAGACTTCCTTCTGAATT	0.423													0	0	0	0.009096	0	3	19										T	112707527	C	T	112707527	3	4	54	1	0	0	0	0	1	0	0	0	1696	864	30	1	11240	1	C12orf51	12	112707527	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	749727	112707527	21144368	684	15462										
TBX3	6926	broad.mit.edu	37	chr12	115112445	115112445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctatggcgtgagtcgggcGacgctttgtccagccgcccg	16	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:115112445G>A	uc001tvt.1	-	7	2259	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	TBX3_uc001tvu.1_Missense_Mutation_p.S412L	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	432					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TGAGTCGGGCGACGCTTTGTC	0.731													0	0	0	0.006214	0	8	28										A	115112445	G	A	115112445	3	1	54	1	0	0	0	0	1	0	0	0	15656	1059	37	1	944	1	TBX3	12	115112445	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2404918	115112445	18739450	685	15463										
PRKAB1	5564	broad.mit.edu	37	chr12	120118103	120118103	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggtacaagaagaagtacgtCaccaccttgttatacaagcc	8	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:120118103C>T	uc009zwu.2	+	8	889	c.786C>T	c.(784-786)GTC>GTT	p.V262V	PRKAB1_uc001txg.2_Silent_p.V262V	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	262					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	AGAAGTACGTCACCACCTTGT	0.527													0	0	0	0.00308	0	6	45										T	120118103	C	T	120118103	2	4	54	1	0	0	0	0	0	0	0	1	12495	813	29	1		1	PRKAB1	12	120118103	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5005658	120118103	13733792	686	15464										
CIT	11113	broad.mit.edu	37	chr12	120220372	120220372	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgctctctgatatcatggaGaagctgcagtgctttgtcat	10	9	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:120220372G>A	uc001txi.1	-	13	1668	c.1615C>T	c.(1615-1617)CTC>TTC	p.L539F	CIT_uc001txh.1_Missense_Mutation_p.L73F|CIT_uc001txj.1_Missense_Mutation_p.L539F	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	539	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		ATATCATGGAGAAGCTGCAGT	0.512													0	0	0	0.004482	0	7	64										A	120220372	G	A	120220372	3	1	54	1	0	0	0	0	1	0	0	0	3438	942	33	1	4608	1	CIT	12	120220372	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	102269	120220372	13631523	687	15465										
GCN1L1	10985	broad.mit.edu	37	chr12	120592798	120592798	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttcccactgatctggaggaGattctgaaataactcgtccc	8	12	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:120592798G>C	uc001txo.2	-	31	3690	c.3677C>G	c.(3676-3678)TCT>TGT	p.S1226C		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1226					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ATCTGGAGGAGATTCTGAAAT	0.532													0	0	0	0.001855	0	13	103										C	120592798	G	C	120592798	3	2	54	1	0	0	0	0	1	0	0	0	6299	942	33	1	4450	1	GCN1L1	12	120592798	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	372426	120592798	13259097	688	15466										
DENR	8562	broad.mit.edu	37	chr12	123253411	123253411	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaggggaggatgaaattatCattcagggagattttacaga	12	4	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:123253411C>T	uc001uda.2	+	7	631	c.495C>T	c.(493-495)ATC>ATT	p.I165I	DENR_uc010tag.1_Intron|DENR_uc001udb.2_Silent_p.I119I	NM_003677	NP_003668	O43583	DENR_HUMAN	density-regulated protein	165	SUI1.						protein binding|translation initiation factor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.28e-05)|Epithelial(86;6.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.199)		ATGAAATTATCATTCAGGGAG	0.343													0	0	0	0.009096	0	3	15										T	123253411	C	T	123253411	2	4	54	1	0	0	0	0	0	0	0	1	4438	816	29	1		1	DENR	12	123253411	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2660613	123253411	10598484	689	15467										
MPHOSPH9	10198	broad.mit.edu	37	chr12	123665727	123665727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacctttactctcctgtgttCttttccaagggactcatact	5	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:123665727C>G	uc001uel.2	-	10	1923	c.1816G>C	c.(1816-1818)GAA>CAA	p.E606Q	MPHOSPH9_uc010tal.1_Missense_Mutation_p.E60Q|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Missense_Mutation_p.E60Q	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	606	Potential.				M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		CTCCTGTGTTCTTTTCCAAGG	0.219													0	0	0	0.001984	0	5	54										G	123665727	C	G	123665727	3	3	54	1	0	0	0	0	1	0	0	0	9728	922	32	1	1323	1	MPHOSPH9	12	123665727	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	412316	123665727	10186168	690	15468										
TCTN2	79867	broad.mit.edu	37	chr12	124158295	124158295	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctcataattcatcctgttCagcacatctactcattcaag	3	12	6	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:124158295C>T	uc001ufp.2	+	4	529	c.401C>T	c.(400-402)TCA>TTA	p.S134L	TCTN2_uc009zya.2_Missense_Mutation_p.S133L	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	134	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TCATCCTGTTCAGCACATCTA	0.448													0	0	0	0.009718	0	34	159										T	124158295	C	T	124158295	3	4	54	1	0	0	0	0	1	0	0	0	15720	838	29	1	415	1	TCTN2	12	124158295	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	492568	124158295	9693600	691	15469										
DNAH10	196385	broad.mit.edu	37	chr12	124409711	124409711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccgtgtggatcgggtctatCgggccgtgactgactatgtg	15	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:124409711C>T	uc001uft.3	+	67	11552	c.11527C>T	c.(11527-11529)CGG>TGG	p.R3843W	DNAH10_uc001ufu.3_5'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3843					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCGGGTCTATCGGGCCGTGAC	0.498													0	0	0	0.00499	0	14	102										T	124409711	C	T	124409711	3	4	54	1	0	0	0	0	1	0	0	0	4598	875	31	1	11793	1	DNAH10	12	124409711	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	251416	124409711	9442184	692	15470										
GPR133	283383	broad.mit.edu	37	chr12	131471689	131471689	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggaaatccaaggagggcctGaaagtctacgtcaacgggac	13	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:131471689G>A	uc001uit.3	+	6	1099	c.540G>A	c.(538-540)CTG>CTA	p.L180L	GPR133_uc010tbm.1_Silent_p.L212L	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	180	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		AGGAGGGCCTGAAAGTCTACG	0.517													0	0	0	0.008291	0	9	63										A	131471689	G	A	131471689	2	1	54	1	0	0	0	0	0	0	0	1	6643	1277	45	1		1	GPR133	12	131471689	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7061978	131471689	2380206	693	15471										
ANKLE2	23141	broad.mit.edu	37	chr12	133327436	133327436	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcataaacatagatcctttCtgggtaagaaaagtaacaaa	6	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr12:133327436C>G	uc001ukx.2	-	3	708	c.641_splice	c.e3-1	p.E214_splice	ANKLE2_uc001uky.3_Splice_Site_p.E152_splice	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2							cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TAGATCCTTTCTGGGTAAGAA	0.433													0	0	0	0.000602	0	4	28										G	133327436	C	G	133327436	5	3	54	1	0	0	0	0	0	0	1	0	633	927	32	1	2220	1	ANKLE2	12	133327436	Splice_Site	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1855747	133327436	524459	694	15472										
SAP18	10284	broad.mit.edu	37	chr13	21721357	21721357	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggcagcaccatgtctggcaGaaaggggactgatgattcca	13	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:21721357G>C	uc001uns.2	+	4	434	c.395G>C	c.(394-396)AGA>ACA	p.R132T		NM_005870	NP_005861	O00422	SAP18_HUMAN	Sin3A-associated protein, 18kDa	113					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|plasma membrane	protein binding|transcription corepressor activity				0		all_cancers(29;2.16e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.79e-05)|Epithelial(112;0.000292)|OV - Ovarian serous cystadenocarcinoma(117;0.00276)|Lung(94;0.0941)		ATGTCTGGCAGAAAGGGGACT	0.443													0	0	0	0.007413	0	15	101										C	21721357	G	C	21721357	3	2	54	1	0	0	0	0	1	0	0	0	13832	942	33	1	409	1	SAP18	13	21721357	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		21721357	93448521	695	15473										
PARP4	143	broad.mit.edu	37	chr13	25067846	25067846	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctcttggctcagagtgcttGaattcatgacttcctccaaa	7	12	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:25067846G>C	uc001upl.2	-	8	873	c.767C>G	c.(766-768)TCA>TGA	p.S256*	PARP4_uc010tdc.1_Nonsense_Mutation_p.S256*	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	256	PARP alpha-helical.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CAGAGTGCTTGAATTCATGAC	0.438													0	0	0	0.004007	0	13	37										C	25067846	G	C	25067846	4	2	54	1	0	0	0	0	0	1	0	0	11463	1294	45	1	4515	1	PARP4	13	25067846	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3346489	25067846	90102032	696	15474										
PARP4	143	broad.mit.edu	37	chr13	25077788	25077788	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacacttggaaatacctgagGatttaacgaaaaggaaaact	9	6	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:25077788G>C	uc001upl.2	-	2	233	c.127C>G	c.(127-129)CCT>GCT	p.P43A	PARP4_uc010tdc.1_Missense_Mutation_p.P43A	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	43	BRCT.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AATACCTGAGGATTTAACGAA	0.398													0	0	0	0.008291	0	7	65										C	25077788	G	C	25077788	3	2	54	1	0	0	0	0	1	0	0	0	11463	1174	41	1	5179	1	PARP4	13	25077788	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9942	25077788	90092090	697	15475										
WASF3	10810	broad.mit.edu	37	chr13	27239225	27239225	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctaacaacttctacatcaGagcaaattctcttcaagaca	5	11	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:27239225G>A	uc001uqv.2	+	4	419	c.194G>A	c.(193-195)AGA>AAA	p.R65K	WASF3_uc001uqw.2_Missense_Mutation_p.R65K	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	65	Potential.				actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TTCTACATCAGAGCAAATTCT	0.423													0	0	0	0.008291	0	10	65										A	27239225	G	A	27239225	3	1	54	1	0	0	0	0	1	0	0	0	17251	942	33	1	200	1	WASF3	13	27239225	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2161437	27239225	87930653	698	15476										
LNX2	222484	broad.mit.edu	37	chr13	28141891	28141891	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcgttgccacccacaatgctGattcctaactgaatgtaagg	8	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:28141891G>A	uc001url.3	-	4	1050	c.741C>T	c.(739-741)ATC>ATT	p.I247I	LNX2_uc001urm.1_Silent_p.I247I	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	247	PDZ 1.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CCACAATGCTGATTCCTAACT	0.458													0	0	0	0.001168	0	6	53										A	28141891	G	A	28141891	2	1	54	1	0	0	0	0	0	0	0	1	8866	1280	45	1		1	LNX2	13	28141891	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	902666	28141891	87027987	699	15477										
USPL1	10208	broad.mit.edu	37	chr13	31233420	31233420	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgatgagtttttttcctcctCagcattaaatgctttagcaa	6	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:31233420C>T	uc001utc.2	+	9	3638	c.3206C>T	c.(3205-3207)TCA>TTA	p.S1069L	USPL1_uc001utd.2_Missense_Mutation_p.S740L|USPL1_uc001ute.1_Missense_Mutation_p.S740L	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	1069					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		TTTTCCTCCTCAGCATTAAAT	0.343													0	0	0	0.000602	0	5	39										T	31233420	C	T	31233420	3	4	54	1	0	0	0	0	1	0	0	0	17089	838	29	1	3236	1	USPL1	13	31233420	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3091529	31233420	83936458	700	15478										
FRY	10129	broad.mit.edu	37	chr13	32709061	32709061	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaatgtgcacattacttcctCgaggtcaaagacaaagatat	8	8	1	2	rs34037604		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:32709061C>T	uc001utx.2	+	9	1402	c.906C>T	c.(904-906)CTC>CTT	p.L302L	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATTACTTCCTCGAGGTCAAAG	0.388													0	0	0	0.003271	0	22	126										T	32709061	C	T	32709061	2	4	54	1	0	0	0	0	0	0	0	1	6063	871	31	1		1	FRY	13	32709061	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1475641	32709061	82460817	701	15479										
FRY	10129	broad.mit.edu	37	chr13	32721489	32721489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actttgggtttacatgattcGaattaaatgtgaaagcaaca	8	5	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:32721489G>A	uc001utx.2	+	12	1746	c.1250G>A	c.(1249-1251)CGA>CAA	p.R417Q	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TACATGATTCGAATTAAATGT	0.398													0	0	0	0.004672	0	3	27										A	32721489	G	A	32721489	3	1	54	1	0	0	0	0	1	0	0	0	6063	1058	37	1	1296	1	FRY	13	32721489	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	12428	32721489	82448389	702	15480										
N4BP2L2	10443	broad.mit.edu	37	chr13	33017213	33017213	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgaaaatccttttcttcctCcttttcttattttttgttga	3	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:33017213C>T	uc010abe.1	-	7	1483	c.1461G>A	c.(1459-1461)AGG>AGA	p.R487R	N4BP2L2_uc001uug.2_Silent_p.R370R|N4BP2L2_uc010abd.1_Silent_p.R400R|N4BP2L2_uc001uuh.2_Silent_p.R318R|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Silent_p.R472R	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	140											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTTTCTTCCTCCTTTTCTTAT	0.343													0	0	0	0.001168	0	4	15										T	33017213	C	T	33017213	2	4	54	1	0	0	0	0	0	0	0	1	10112	854	30	1		1	N4BP2L2	13	33017213	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	295724	33017213	82152665	703	15481										
STARD13	90627	broad.mit.edu	37	chr13	33700224	33700224	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggttacagccctacctgatcGaggcagttgctgcgtagata	12	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:33700224G>C	uc001uuw.2	-	7	2202	c.2076C>G	c.(2074-2076)CTC>CTG	p.L692L	STARD13_uc001uuu.2_Silent_p.L684L|STARD13_uc001uuv.2_Silent_p.L574L|STARD13_uc001uux.2_Silent_p.L657L|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	692	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CTACCTGATCGAGGCAGTTGC	0.552													0	0	0	0.006122	0	15	107										C	33700224	G	C	33700224	2	2	54	1	0	0	0	0	0	0	0	1	15255	1045	37	1		1	STARD13	13	33700224	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	683011	33700224	81469654	704	15482										
FREM2	341640	broad.mit.edu	37	chr13	39433625	39433625	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cactggactccatatactttCagcctggctcccgggtacag	9	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:39433625C>T	uc001uwv.2	+	14	7726	c.7417C>T	c.(7417-7419)CAG>TAG	p.Q2473*	FREM2_uc001uww.2_Nonsense_Mutation_p.Q559*	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2473	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CATATACTTTCAGCCTGGCTC	0.542													0	0	0	0.003163	0	13	80										T	39433625	C	T	39433625	4	4	54	1	0	0	0	0	0	1	0	0	6045	827	29	1	7471	1	FREM2	13	39433625	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5733401	39433625	75736253	705	15483										
KBTBD7	84078	broad.mit.edu	37	chr13	41767323	41767323	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccgagtaagggtcatagcaGagaaagggatctctaggatg	14	7	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:41767323G>C	uc001uxw.1	-	1	1380	c.1071C>G	c.(1069-1071)CTC>CTG	p.L357L	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	357							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GGTCATAGCAGAGAAAGGGAT	0.493													0	0	0	0.004482	0	3	38										C	41767323	G	C	41767323	2	2	54	1	0	0	0	0	0	0	0	1	7998	929	33	1		1	KBTBD7	13	41767323	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2333698	41767323	73402555	706	15484										
TSC22D1	8848	broad.mit.edu	37	chr13	45148962	45148962	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctaccttttttaaagggctCagaactagaatctaacttca	5	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:45148962C>G	uc001uzn.3	-	1	1740	c.1249G>C	c.(1249-1251)GAG>CAG	p.E417Q	TSC22D1_uc001uzo.1_Missense_Mutation_p.E417Q	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	417					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TTAAAGGGCTCAGAACTAGAA	0.438													0	0	0	0.00245	0	13	67										G	45148962	C	G	45148962	3	3	54	1	0	0	0	0	1	0	0	0	16604	835	29	1	2113	1	TSC22D1	13	45148962	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3381639	45148962	70020916	707	15485										
KIAA1704	55425	broad.mit.edu	37	chr13	45589108	45589108	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaacagacagcagtgaagatGaggatattattggaccaatg	11	5	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:45589108G>C	uc001uzq.2	+	5	533	c.430G>C	c.(430-432)GAG>CAG	p.E144Q	KIAA1704_uc010tfo.1_RNA|KIAA1704_uc001uzr.1_Missense_Mutation_p.E144Q|KIAA1704_uc001uzs.2_Missense_Mutation_p.E21Q|KIAA1704_uc001uzt.2_5'UTR	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425	144										pancreas(1)|skin(1)	2		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		CAGTGAAGATGAGGATATTAT	0.348													0	0	0	0.001855	0	10	48										C	45589108	G	C	45589108	3	2	54	1	0	0	0	0	1	0	0	0	8252	1291	45	1	448	1	KIAA1704	13	45589108	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	440146	45589108	69580770	708	15486										
C13orf18	80183	broad.mit.edu	37	chr13	46942258	46942258	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtcatttcagagtcaggctGatcactcccaagtaacccac	7	13	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:46942258G>A	uc010acl.2	-	5	1350	c.745C>T	c.(745-747)CAG>TAG	p.Q249*	C13orf18_uc001vbf.3_Nonsense_Mutation_p.Q182*|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Nonsense_Mutation_p.Q92*|C13orf18_uc010acm.2_Nonsense_Mutation_p.Q114*|C13orf18_uc010acn.2_Nonsense_Mutation_p.Q34*|C13orf18_uc001vbe.3_Nonsense_Mutation_p.Q249*|C13orf18_uc001vbh.3_Nonsense_Mutation_p.Q249*|C13orf18_uc001vbi.3_Nonsense_Mutation_p.Q92*|C13orf18_uc010aco.1_Nonsense_Mutation_p.Q249*	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	249											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		GAGTCAGGCTGATCACTCCCA	0.408													0	0	0	0.010504	0	16	83										A	46942258	G	A	46942258	4	1	54	1	0	0	0	0	0	1	0	0	1720	1299	45	1	1287	1	C13orf18	13	46942258	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1353150	46942258	68227620	709	15487										
LRCH1	23143	broad.mit.edu	37	chr13	47263286	47263286	+	Silent	SNP	G	G	C													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaagaaggattctgattcGggagttggaagtgataatgg							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:47263286G>C	uc001vbj.2	+	7	1205	c.969G>C	c.(967-969)TCG>TCC	p.S323S	LRCH1_uc010acp.2_Silent_p.S323S|LRCH1_uc001vbk.2_Silent_p.S323S|LRCH1_uc001vbl.3_Silent_p.S323S	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	323										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		ATTCTGATTCGGGAGTTGGAA	0.343													0	0	0	0.013114	0	34	102										C	47263286	G	C	47263286	2	2	54	1	0	0	0	0	0	0	0	1	8932	1103	39	4		4	LRCH1	13	47263286	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	321028	47263286	67906592	710	15488	75	2								
LRCH1	23143	broad.mit.edu	37	chr13	47263293	47263293	+	Missense_Mutation	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggattctgattcgggagttGgaagtgataatggagataag							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:47263293G>A	uc001vbj.2	+	7	1212	c.976G>A	c.(976-978)GGA>AGA	p.G326R	LRCH1_uc010acp.2_Missense_Mutation_p.G326R|LRCH1_uc001vbk.2_Missense_Mutation_p.G326R|LRCH1_uc001vbl.3_Missense_Mutation_p.G326R	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	326										ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TTCGGGAGTTGGAAGTGATAA	0.353													0	0	0	0.00361	0	32	109										A	47263293	G	A	47263293	3	1	54	1	0	0	0	0	1	0	0	0	8932	1349	47	2	1002	2	LRCH1	13	47263293	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7	47263293	67906585	711	15489	75	2								
PHF11	51131	broad.mit.edu	37	chr13	50080827	50080827	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgtgcactctgccccaaaGatgtcgaatataatgtccta	7	11	1	1	rs73188692	by1000genomes	TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:50080827G>A	uc001vdb.2	+	2	488	c.151G>A	c.(151-153)GAT>AAT	p.D51N	PHF11_uc010tgl.1_Missense_Mutation_p.D51N|PHF11_uc001vdc.2_Missense_Mutation_p.D12N|PHF11_uc001vdd.2_RNA	NM_001040443	NP_001035533	Q9UIL8	PHF11_HUMAN	PHD finger protein 11 isoform a	51					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)		CTGCCCCAAAGATGTCGAATA	0.363													0	0	0	0.008291	0	8	48										A	50080827	G	A	50080827	3	1	54	1	0	0	0	0	1	0	0	0	11822	942	33	1	157	1	PHF11	13	50080827	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2817534	50080827	65089051	712	15490										
TBC1D4	9882	broad.mit.edu	37	chr13	75861065	75861065	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttttgataagccattttttCttgttccagggtccggatta	8	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:75861065C>G	uc001vjl.1	-	21	4107	c.3760G>C	c.(3760-3762)GAA>CAA	p.E1254Q	TBC1D4_uc010tht.1_Missense_Mutation_p.E464Q|TBC1D4_uc010thu.1_Missense_Mutation_p.E411Q|TBC1D4_uc010aer.2_Missense_Mutation_p.E1246Q|TBC1D4_uc010aes.2_Missense_Mutation_p.E1191Q	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1254						cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GCCATTTTTTCTTGTTCCAGG	0.453													0	0	0	0.001168	0	4	40										G	75861065	C	G	75861065	3	3	54	1	0	0	0	0	1	0	0	0	15619	922	32	1	140	1	TBC1D4	13	75861065	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	25780238	75861065	39308813	713	15491										
RBM26	64062	broad.mit.edu	37	chr13	79942973	79942973	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcggtagtgttgtttccatGatgagtaggagcaattactg	12	5	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:79942973G>T	uc001vkz.2	-	6	801	c.787C>A	c.(787-789)CAT>AAT	p.H263N	RBM26_uc001vky.2_Missense_Mutation_p.H263N|RBM26_uc001vla.2_Missense_Mutation_p.H263N|RBM26_uc001vkx.2_5'UTR|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	263					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTGTTTCCATGATGAGTAGGA	0.418													1	0	2.17888e-05	0.006214	2.25545e-05	7	74										T	79942973	G	T	79942973	3	4	54	1	0	0	0	0	1	0	0	0	13126	1290	45	3	2219	3	RBM26	13	79942973	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4081908	79942973	35226905	714	15492										
RBM26	64062	broad.mit.edu	37	chr13	79943032	79943032	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taggtacagggtagtggccaGatgaaatactaggtaccgaa	13	6	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:79943032G>C	uc001vkz.2	-	6	742	c.728C>G	c.(727-729)TCT>TGT	p.S243C	RBM26_uc001vky.2_Missense_Mutation_p.S243C|RBM26_uc001vla.2_Missense_Mutation_p.S243C|RBM26_uc001vkx.2_Translation_Start_Site|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	243					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTAGTGGCCAGATGAAATACT	0.393													0	0	0	0.010729	0	8	80										C	79943032	G	C	79943032	3	2	54	1	0	0	0	0	1	0	0	0	13126	942	33	1	2278	1	RBM26	13	79943032	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	59	79943032	35226846	715	15493										
SLITRK5	26050	broad.mit.edu	37	chr13	88328435	88328435	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggtgggggatgtagtttgTgagacccccttccgcttaca	13	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:88328435T>A	uc001vln.2	+	2	1011	c.792T>A	c.(790-792)TGT>TGA	p.C264*	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	264	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATGTAGTTTGTGAGACCCCCT	0.507													0	0	0	0.006214	0	6	123										A	88328435	T	A	88328435	4	1	54	1	0	0	0	0	0	1	0	0	14746	1702	59	5	794	5	SLITRK5	13	88328435	Nonsense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	8385403	88328435	26841443	716	15494										
C13orf39	196541	broad.mit.edu	37	chr13	103343304	103343304	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctatgaagagatggttctatCttgttggattctgtgaagca	11	5	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:103343304C>G	uc001vpj.2	-	2	147	c.141G>C	c.(139-141)AAG>AAC	p.K47N	C13orf39_uc001vpk.2_Missense_Mutation_p.K47N	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	47							methyltransferase activity				0						ATGGTTCTATCTTGTTGGATT	0.393													0	0	0	0.008291	0	9	68										G	103343304	C	G	103343304	3	3	54	1	0	0	0	0	1	0	0	0	1732	912	32	1	665	1	C13orf39	13	103343304	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	15014869	103343304	11826574	717	15495										
MYO16	23026	broad.mit.edu	37	chr13	109535458	109535458	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctgtgttcctcgctgcctCctcacctcttctcctgtgtg	8	16	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:109535458C>G	uc001vqt.1	+	13	1537	c.1411C>G	c.(1411-1413)CCT>GCT	p.P471A	MYO16_uc010agk.1_Missense_Mutation_p.P493A|MYO16_uc001vqu.1_Missense_Mutation_p.P271A	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	471	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTCGCTGCCTCCTCACCTCTT	0.562													0	0	0	0.002299	0	19	177										G	109535458	C	G	109535458	3	3	54	1	0	0	0	0	1	0	0	0	10064	855	30	1	1457	1	MYO16	13	109535458	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	6192154	109535458	5634420	718	15496										
COL4A2	1284	broad.mit.edu	37	chr13	110960258	110960258	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acgaaccgccagcatggggaGagaccagcgcgcggtggccg	17	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr13:110960258G>A	uc001vqx.2	+	2	297	c.8G>A	c.(7-9)AGA>AAA	p.R3K	COL4A1_uc001vqw.3_5'Flank|COL4A1_uc010agl.2_5'Flank	NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	3					angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGCATGGGGAGAGACCAGCGC	0.662													0	0	0	0.00245	0	10	86										A	110960258	G	A	110960258	3	1	54	1	0	0	0	0	1	0	0	0	3690	942	33	1	10	1	COL4A2	13	110960258	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1424800	110960258	4209620	719	15497										
OR4K15	81127	broad.mit.edu	37	chr14	20444469	20444469	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgaaggcccgctccacattGactgctcacatcactgtggt	10	14	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:20444469G>A	uc010tkx.1	+	1	792	c.792G>A	c.(790-792)TTG>TTA	p.L264L		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	264	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCTCCACATTGACTGCTCACA	0.463													0	0	0	0.000602	0	4	28										A	20444469	G	A	20444469	2	1	54	1	0	0	0	0	0	0	0	1	11070	1281	45	1		1	OR4K15	14	20444469	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		20444469	86905071	720	15498										
FITM1	161247	broad.mit.edu	37	chr14	24601689	24601689	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcagccggccaccagtggcGaggctacaccgtctcctccc	12	18	1	0	rs147303563		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:24601689G>A	uc001wmf.2	+	2	634	c.536G>A	c.(535-537)CGA>CAA	p.R179Q		NM_203402	NP_981947	A5D6W6	FITM1_HUMAN	fat-inducing transcript 1	179	Extracellular (Potential).				lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane					0						CACCAGTGGCGAGGCTACACC	0.652													0	0	0	0.00499	0	14	94										A	24601689	G	A	24601689	3	1	54	1	0	0	0	0	1	0	0	0	5898	1058	37	1	542	1	FITM1	14	24601689	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4157220	24601689	82747851	721	15499										
DHRS1	115817	broad.mit.edu	37	chr14	24768168	24768168	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaggaagcactcacctcctGagcaacaacgcgaagggtgt	12	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:24768168G>A	uc001woj.1	-	2	414	c.145C>T	c.(145-147)CAG>TAG	p.Q49*	C14orf21_uc001wol.1_5'Flank|DHRS1_uc001wok.2_Nonsense_Mutation_p.Q49*	NM_138452	NP_612461	Q96LJ7	DHRS1_HUMAN	dehydrogenase/reductase (SDR family) member 1	49						endoplasmic reticulum	binding|oxidoreductase activity				0				GBM - Glioblastoma multiforme(265;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(311;0.0442)		CTCACCTCCTGAGCAACAACG	0.547													0	0	0	0.010504	0	19	94										A	24768168	G	A	24768168	4	1	54	1	0	0	0	0	0	1	0	0	4486	1299	45	1	828	1	DHRS1	14	24768168	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	166479	24768168	82581372	722	15500										
STXBP6	29091	broad.mit.edu	37	chr14	25288302	25288302	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggtcttctgtcttctcctCtgctcggcctaatcgctctc	7	16	6	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:25288302C>G	uc001wpu.2	-	5	1265	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	STXBP6_uc001wpv.2_Missense_Mutation_p.E184Q|STXBP6_uc001wpw.2_Missense_Mutation_p.E184Q|STXBP6_uc001wpx.1_RNA|STXBP6_uc001wpt.2_Missense_Mutation_p.E82Q	NM_014178	NP_054897	Q8NFX7	STXB6_HUMAN	amisyn	184	v-SNARE coiled-coil homology.				vesicle-mediated transport	cytoplasm|integral to membrane					0				GBM - Glioblastoma multiforme(265;0.0296)		GTCTTCTCCTCTGCTCGGCCT	0.572													0	0	0	0.012319	0	17	126										G	25288302	C	G	25288302	3	3	54	1	0	0	0	0	1	0	0	0	15357	922	32	1	90	1	STXBP6	14	25288302	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	520134	25288302	82061238	723	15501										
SCFD1	23256	broad.mit.edu	37	chr14	31177222	31177222	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcacgagtcatgaatacagGatcacagtttgtgatggaag	11	6	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:31177222G>C	uc001wqm.1	+	19	1604	c.1580G>C	c.(1579-1581)GGA>GCA	p.G527A	SCFD1_uc001wqn.1_Missense_Mutation_p.G460A|SCFD1_uc010tpg.1_Missense_Mutation_p.G468A|SCFD1_uc010tph.1_Missense_Mutation_p.G342A|SCFD1_uc010amf.1_Missense_Mutation_p.G342A|SCFD1_uc010tpi.1_Missense_Mutation_p.G435A|SCFD1_uc010amd.1_Intron|SCFD1_uc010ame.1_Missense_Mutation_p.G460A	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	527					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		ATGAATACAGGATCACAGTTT	0.358													0	0	0	0.010729	0	9	57										C	31177222	G	C	31177222	3	2	54	1	0	0	0	0	1	0	0	0	13889	1174	41	1	1654	1	SCFD1	14	31177222	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5888920	31177222	76172318	724	15502										
AKAP6	9472	broad.mit.edu	37	chr14	33292806	33292806	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgggaaagagatttcagaGagtgagcattgtaagtgtaa	13	3	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:33292806G>C	uc001wrq.2	+	13	5957	c.5787G>C	c.(5785-5787)GAG>GAC	p.E1929D		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1929					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGATTTCAGAGAGTGAGCATT	0.373													0	0	0	0.001168	0	6	28										C	33292806	G	C	33292806	3	2	54	1	0	0	0	0	1	0	0	0	455	933	33	1	5833	1	AKAP6	14	33292806	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2115584	33292806	74056734	725	15503										
FAM179B	23116	broad.mit.edu	37	chr14	45433339	45433339	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatgaatgctgtgcaggccaGattggctaggaaaaccttac	12	8	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:45433339G>A	uc001wvv.2	+	1	1924	c.1715G>A	c.(1714-1716)AGA>AAA	p.R572K	FAM179B_uc001wvw.2_Missense_Mutation_p.R572K|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.R572K|FAM179B_uc001wvu.2_Missense_Mutation_p.R572K	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	572							binding			skin(2)|upper_aerodigestive_tract(1)	3						GTGCAGGCCAGATTGGCTAGG	0.468													0	0	0	0.003163	0	14	118										A	45433339	G	A	45433339	3	1	54	1	0	0	0	0	1	0	0	0	5506	942	33	1	1717	1	FAM179B	14	45433339	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	12140533	45433339	61916201	726	15504										
C14orf104	55172	broad.mit.edu	37	chr14	50100987	50100987	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagcgccgcctgctcggccGagcgcaacagcggcagttcg	14	17	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:50100987G>A	uc001wws.3	-	1	962	c.881C>T	c.(880-882)TCG>TTG	p.S294L	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.S294L	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	294					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTGCTCGGCCGAGCGCAACAG	0.657									Kartagener_syndrome				0	0	0	0.006122	0	12	64										A	50100987	G	A	50100987	3	1	54	1	0	0	0	0	1	0	0	0	1736	1059	37	1	1644	1	C14orf104	14	50100987	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4667648	50100987	57248553	727	15505										
PYGL	5836	broad.mit.edu	37	chr14	51411041	51411041	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggttgaaactcttcttcagCtctgccacgttctccacgcc	7	16	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:51411041C>G	uc001wyu.2	-	1	208	c.81G>C	c.(79-81)GAG>GAC	p.E27D	PYGL_uc010tqq.1_Missense_Mutation_p.E27D|PYGL_uc001wyv.2_5'UTR|PYGL_uc001wyw.3_Missense_Mutation_p.E27D	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	27					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	TCTTCTTCAGCTCTGCCACGT	0.607													0	0	0	0.001368	0	10	78										G	51411041	C	G	51411041	3	3	54	1	0	0	0	0	1	0	0	0	12861	796	28	4	2542	4	PYGL	14	51411041	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1310054	51411041	55938499	728	15506										
GPR137C	283554	broad.mit.edu	37	chr14	53020091	53020091	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcggctgctcctgtaccgcGagcggcggctgagttaccag	16	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:53020091G>A	uc001wzu.3	+	1	226	c.226G>A	c.(226-228)GAG>AAG	p.E76K	TXNDC16_uc010tqu.1_5'Flank|TXNDC16_uc001wzs.2_5'Flank|TXNDC16_uc010aoe.2_5'Flank|GPR137C_uc001wzt.3_Missense_Mutation_p.E76K	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	76	Cytoplasmic (Potential).					integral to membrane					0	Breast(41;0.0716)					CCTGTACCGCGAGCGGCGGCT	0.677													0	0	0	0.001168	0	3	17										A	53020091	G	A	53020091	3	1	54	1	0	0	0	0	1	0	0	0	6647	1059	37	1	228	1	GPR137C	14	53020091	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1609050	53020091	54329449	729	15507										
DLGAP5	9787	broad.mit.edu	37	chr14	55618639	55618639	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggataaacaatccaccttCaagtctgtcttatttacaac	4	11	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:55618639C>G	uc001xbs.2	-	17	2359	c.2142G>C	c.(2140-2142)TTG>TTC	p.L714F	DLGAP5_uc001xbt.2_Missense_Mutation_p.L714F	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	714					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						AATCCACCTTCAAGTCTGTCT	0.303													0	0	0	0.00308	0	5	39										G	55618639	C	G	55618639	3	3	54	1	0	0	0	0	1	0	0	0	4563	825	29	1	505	1	DLGAP5	14	55618639	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2598548	55618639	51730901	730	15508										
JKAMP	51528	broad.mit.edu	37	chr14	59965517	59965517	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccgacctcttctggtgaaGaagattgcatgtgggttagg	13	8	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:59965517G>A	uc001xei.3	+	5	1075	c.573G>A	c.(571-573)AAG>AAA	p.K191K	JKAMP_uc001xef.3_Silent_p.K177K|JKAMP_uc001xeh.3_Silent_p.K171K|JKAMP_uc001xeg.3_Silent_p.K185K|JKAMP_uc010try.1_Silent_p.K114K|JKAMP_uc001xej.3_Silent_p.K114K	NM_001098625	NP_001092095	Q9P055	JKAMP_HUMAN	JNK1-associated membrane protein isoform 2	192	Cytoplasmic (Potential).				ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)	1						TTCTGGTGAAGAAGATTGCAT	0.363													0	0	0	0.001168	0	4	22										A	59965517	G	A	59965517	2	1	54	1	0	0	0	0	0	0	0	1	7949	933	33	1		1	JKAMP	14	59965517	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4346878	59965517	47384023	731	15509										
RDH11	51109	broad.mit.edu	37	chr14	68159246	68159246	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctggttccctgtcgtggtCtggatctctttggccaccaa	11	12	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:68159246C>T	uc001xjv.3	-	3	348	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	RDH11_uc001xjw.3_Silent_p.Q73Q|RDH11_uc001xjx.3_Silent_p.Q86Q	NM_016026	NP_057110	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11	86	Cytoplasmic (Potential).				retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	CTGTCGTGGTCTGGATCTCTT	0.488													0	0	0	0.00361	0	36	214										T	68159246	C	T	68159246	2	4	54	1	0	0	0	0	0	0	0	1	13190	912	32	1		1	RDH11	14	68159246	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	8193729	68159246	39190294	732	15510										
HEATR4	399671	broad.mit.edu	37	chr14	73959790	73959790	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctttatcactgcttcagtgtCacaaacctcggaaggtcttc	7	12	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:73959790C>T	uc010tua.1	-	17	3093	c.2683G>A	c.(2683-2685)GAC>AAC	p.D895N	C14orf169_uc001xok.1_3'UTR	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		GCTTCAGTGTCACAAACCTCG	0.398													0	0	0	0.008291	0	7	82										T	73959790	C	T	73959790	3	4	54	1	0	0	0	0	1	0	0	0	7030	826	29	1	264	1	HEATR4	14	73959790	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5800544	73959790	33389750	733	15511										
HEATR4	399671	broad.mit.edu	37	chr14	73959826	73959826	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttctaggaagaaccatctCatctaggtacaaaaggaaaa	7	8	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:73959826C>T	uc010tua.1	-	17	3057	c.2647G>A	c.(2647-2649)GAG>AAG	p.E883K	C14orf169_uc001xok.1_3'UTR	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		AGAACCATCTCATCTAGGTAC	0.433													0	0	0	0.000602	0	4	52										T	73959826	C	T	73959826	3	4	54	1	0	0	0	0	1	0	0	0	7030	835	29	1	300	1	HEATR4	14	73959826	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	36	73959826	33389714	734	15512										
LTBP2	4053	broad.mit.edu	37	chr14	75078187	75078187	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcgcggcggggttgggggcGcagccccagaccgctgtggg	20	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:75078187G>A	uc001xqa.2	-	1	848	c.461C>T	c.(460-462)GCG>GTG	p.A154V		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	154					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGTTGGGGGCGCAGCCCCAGA	0.726													0	0	0	0.001984	0	6	59										A	75078187	G	A	75078187	3	1	54	1	0	0	0	0	1	0	0	0	9074	1087	38	2	5148	2	LTBP2	14	75078187	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1118361	75078187	32271353	735	15513										
TTLL5	23093	broad.mit.edu	37	chr14	76211452	76211452	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccttagcgttgccgtccactCtctgccagtgatgcggaaat	10	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:76211452C>G	uc001xrx.2	+	16	1501	c.1296C>G	c.(1294-1296)CTC>CTG	p.L432L	TTLL5_uc010ask.1_Silent_p.L446L|TTLL5_uc001xrz.2_5'UTR|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	432					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCCGTCCACTCTCTGCCAGTG	0.458													0	0	0	0.00308	0	7	20										G	76211452	C	G	76211452	2	3	54	1	0	0	0	0	0	0	0	1	16727	900	32	1		1	TTLL5	14	76211452	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1133265	76211452	31138088	736	15514										
C14orf148	122945	broad.mit.edu	37	chr14	77872309	77872309	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgacaaaatctgttaattgCaactttgggcaagatgctgt	9	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:77872309C>G	uc001xtr.2	-	5	999	c.852G>C	c.(850-852)TTG>TTC	p.L284F		NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	hypothetical protein LOC122945 isoform 1	284					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		CTGTTAATTGCAACTTTGGGC	0.473													0	0	0	0.000602	0	3	27										G	77872309	C	G	77872309	3	3	54	1	0	0	0	0	1	0	0	0	1751	709	25	4	235	4	C14orf148	14	77872309	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1660857	77872309	29477231	737	15515										
NDUFB1	4707	broad.mit.edu	37	chr14	92588065	92588065	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccagtggaagctgcgacctCgggacctgccattcgccgcg	14	15	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:92588065C>T	uc001yaf.2	-	1	89	c.57G>A	c.(55-57)CCG>CCA	p.P19P	NDUFB1_uc001yag.1_RNA|CPSF2_uc001yah.1_5'Flank	NM_004545	NP_004536	O75438	NDUB1_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	Error:Variant_position_missing_in_O75438_after_alignment					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.205)	NADH(DB00157)	GCTGCGACCTCGGGACCTGCC	0.612													0	0	0	0.004007	0	13	94										T	92588065	C	T	92588065	2	4	54	1	0	0	0	0	0	0	0	1	10278	871	31	1		1	NDUFB1	14	92588065	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	14715756	92588065	14761475	738	15516										
BTBD7	55727	broad.mit.edu	37	chr14	93730309	93730309	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggcaattaaggtatctaatGagatgctctcagcaatgata	9	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:93730309G>A	uc001ybo.2	-	4	1519	c.1193C>T	c.(1192-1194)TCA>TTA	p.S398L	BTBD7_uc010aur.2_Intron|BTBD7_uc010two.1_Intron|BTBD7_uc001ybp.2_Missense_Mutation_p.S47L|BTBD7_uc001ybq.3_Missense_Mutation_p.S313L	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	398										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		GGTATCTAATGAGATGCTCTC	0.388													0	0	0	0.006214	0	7	58										A	93730309	G	A	93730309	3	1	54	1	0	0	0	0	1	0	0	0	1546	1294	45	1	2237	1	BTBD7	14	93730309	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1142244	93730309	13619231	739	15517										
KIAA1409	57578	broad.mit.edu	37	chr14	94088398	94088398	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcctaaagaggatttagatCtgatagatctatcctcagat	7	8	3	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:94088398C>T	uc001ybv.1	+	28	4437	c.4354C>T	c.(4354-4356)CTG>TTG	p.L1452L	KIAA1409_uc001ybs.1_Silent_p.L1430L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1607						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GGATTTAGATCTGATAGATCT	0.473													0	0	0	0.00245	0	12	72										T	94088398	C	T	94088398	2	4	54	1	0	0	0	0	0	0	0	1	8230	912	32	1		1	KIAA1409	14	94088398	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	358089	94088398	13261142	740	15518										
KIAA1409	57578	broad.mit.edu	37	chr14	94128992	94128992	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aactgctcagctttgtaattCagaatgccgtcttcactctg	7	11	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:94128992C>T	uc001ybv.1	+	39	6303	c.6220C>T	c.(6220-6222)CAG>TAG	p.Q2074*	KIAA1409_uc001ybs.1_Nonsense_Mutation_p.Q2052*	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2229	Helical; (Potential).					integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CTTTGTAATTCAGAATGCCGT	0.418													0	0	0	0.001168	0	5	29										T	94128992	C	T	94128992	4	4	54	1	0	0	0	0	0	1	0	0	8230	827	29	1	6304	1	KIAA1409	14	94128992	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	40594	94128992	13220548	741	15519										
HSP90AA1	3320	broad.mit.edu	37	chr14	102552649	102552649	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caactgggcaatttctgcctGaaaggcgaacgtctcaacct	9	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:102552649G>A	uc001yku.3	-	2	257	c.67C>T	c.(67-69)CAG>TAG	p.Q23*	HSP90AA1_uc001ykv.3_Nonsense_Mutation_p.Q145*|HSP90AA1_uc001ykw.1_5'UTR|HSP90AA1_uc001ykx.1_Nonsense_Mutation_p.Q12*	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	23					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	ATTTCTGCCTGAAAGGCGAAC	0.468													0	0	0	0.00245	0	10	91										A	102552649	G	A	102552649	4	1	54	1	0	0	0	0	0	1	0	0	7401	1299	45	1	2171	1	HSP90AA1	14	102552649	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8423657	102552649	4796891	742	15520										
KLC1	3831	broad.mit.edu	37	chr14	104121117	104121117	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggagaaatcaaacatgatCcggaagtcactggagatgtt	12	6	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:104121117C>T	uc001yno.2	+	2	524	c.216C>T	c.(214-216)ATC>ATT	p.I72I	KLC1_uc010tyd.1_Silent_p.I231I|KLC1_uc010tye.1_Silent_p.I68I|KLC1_uc001ynm.1_Silent_p.I72I|KLC1_uc001ynn.1_Silent_p.I68I|KLC1_uc010tyf.1_Silent_p.I72I	NM_182923	NP_891553	Q07866	KLC1_HUMAN	kinesin light chain 1 isoform 2	72					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0		Melanoma(154;0.155)|all_epithelial(191;0.19)				CAAACATGATCCGGAAGTCAC	0.423													0	0	0	0.008291	0	9	61										T	104121117	C	T	104121117	2	4	54	1	0	0	0	0	0	0	0	1	8333	845	30	1		1	KLC1	14	104121117	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1568468	104121117	3228423	743	15521										
KIAA0284	283638	broad.mit.edu	37	chr14	105354098	105354098	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacatcctggccatgccccgGaagcgggccggctccttcac	12	17	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:105354098G>A	uc010axb.2	+	12	3746	c.3522G>A	c.(3520-3522)CGG>CGA	p.R1174R	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Silent_p.R1104R|KIAA0284_uc001yps.2_Silent_p.R1080R|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1174						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CCATGCCCCGGAAGCGGGCCG	0.692													0	0	0	0.001168	0	5	12										A	105354098	G	A	105354098	2	1	54	1	0	0	0	0	0	0	0	1	8166	1161	41	1		1	KIAA0284	14	105354098	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1232981	105354098	1995442	744	15522										
AHNAK2	113146	broad.mit.edu	37	chr14	105405994	105405994	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacaccttagaatatctgtgGatgatttgctctcagaagct	8	9	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr14:105405994G>A	uc010axc.1	-	7	15914	c.15794C>T	c.(15793-15795)TCC>TTC	p.S5265F	AHNAK2_uc001ypx.2_Missense_Mutation_p.S5165F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5265						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AATATCTGTGGATGATTTGCT	0.512													0	0	0	0.008871	0	18	114										A	105405994	G	A	105405994	3	1	54	1	0	0	0	0	1	0	0	0	415	1174	41	1	1597	1	AHNAK2	14	105405994	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	51896	105405994	1943546	745	15523										
MKRN3	7681	broad.mit.edu	37	chr15	23811991	23811991	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaagtgccagacagtttgaGaacaggatcgtcaagtcttg	12	7	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:23811991G>C	uc001ywh.3	+	1	1538	c.1062G>C	c.(1060-1062)GAG>GAC	p.E354D	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.E354D	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	354	RING-type.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GACAGTTTGAGAACAGGATCG	0.507													0	0	0	0.003163	0	15	144										C	23811991	G	C	23811991	3	2	54	1	0	0	0	0	1	0	0	0	9608	933	33	1	1064	1	MKRN3	15	23811991	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		23811991	78719401	746	15524										
INO80	54617	broad.mit.edu	37	chr15	41362724	41362724	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttaccaaggcccatttcatCagcaagaatgccattaatac	5	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:41362724C>T	uc001zni.2	-	13	1840	c.1627G>A	c.(1627-1629)GAT>AAT	p.D543N	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	543	ATP (By similarity).|Helicase ATP-binding.|Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						CCCATTTCATCAGCAAGAATG	0.408													0	0	0	0.005443	0	21	61										T	41362724	C	T	41362724	3	4	54	1	0	0	0	0	1	0	0	0	7746	826	29	1	3139	1	INO80	15	41362724	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	17550733	41362724	61168668	747	15525										
OIP5	11339	broad.mit.edu	37	chr15	41624585	41624585	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgcgggccggcggctggctCctcagcccccagccctgcgg	15	19	1	0	rs148616469		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:41624585C>T	uc001znp.2	-	1	235	c.175G>A	c.(175-177)GAG>AAG	p.E59K	NUSAP1_uc001znq.3_5'Flank|NUSAP1_uc001znr.3_5'Flank|NUSAP1_uc001zns.3_5'Flank|NUSAP1_uc010bce.2_5'Flank|NUSAP1_uc001znt.3_5'Flank|NUSAP1_uc001znv.3_5'Flank|NUSAP1_uc001znu.3_5'Flank|NUSAP1_uc010ucw.1_5'Flank	NM_007280	NP_009211	O43482	MS18B_HUMAN	Opa interacting protein 5	59					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCGGCTGGCTCCTCAGCCCCC	0.672													0	0	0	0.00632	0	21	48										T	41624585	C	T	41624585	3	4	54	1	0	0	0	0	1	0	0	0	10848	864	30	1	534	1	OIP5	15	41624585	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	261861	41624585	60906807	748	15526										
MGA	23269	broad.mit.edu	37	chr15	42058963	42058963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgatgttcaaggggagagtGactctatcagtcccctcctc	10	12	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:42058963G>A	uc010ucy.1	+	24	8864	c.8683G>A	c.(8683-8685)GAC>AAC	p.D2895N	MGA_uc010ucz.1_Missense_Mutation_p.D2686N	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2856						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGGGGAGAGTGACTCTATCAG	0.463													0	0	0	0.00333	0	19	59										A	42058963	G	A	42058963	3	1	54	1	0	0	0	0	1	0	0	0	9540	1290	45	1	8773	1	MGA	15	42058963	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	434378	42058963	60472429	749	15527										
CAPN3	825	broad.mit.edu	37	chr15	42691775	42691775	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctctgcagtctgacaagcttCagacctggacagtgtctgtg	11	11	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:42691775C>T	uc001zpn.1	+	10	1585	c.1279C>T	c.(1279-1281)CAG>TAG	p.Q427*	CAPN3_uc001zpk.1_Nonsense_Mutation_p.Q200*|CAPN3_uc001zpl.1_Nonsense_Mutation_p.Q340*|CAPN3_uc010udf.1_Nonsense_Mutation_p.Q340*|CAPN3_uc010udg.1_Nonsense_Mutation_p.Q292*|CAPN3_uc001zpo.1_Nonsense_Mutation_p.Q427*|CAPN3_uc001zpp.1_Nonsense_Mutation_p.Q379*|CAPN3_uc001zpq.1_5'Flank	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	427	Domain III.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		TGACAAGCTTCAGACCTGGAC	0.562													0	0	0	0.001168	0	6	27										T	42691775	C	T	42691775	4	4	54	1	0	0	0	0	0	1	0	0	2628	827	29	1	1369	1	CAPN3	15	42691775	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	632812	42691775	59839617	750	15528										
LEO1	123169	broad.mit.edu	37	chr15	52258074	52258074	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtggttgttcttcatcatcaGaattctgtttctcatcatca	6	9	8	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:52258074G>A	uc002abo.2	-	2	702	c.686C>T	c.(685-687)TCT>TTT	p.S229F	LEO1_uc010bfd.2_Missense_Mutation_p.S229F	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	229	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TTCATCATCAGAATTCTGTTT	0.423													0	0	0	0.00361	0	56	131										A	52258074	G	A	52258074	3	1	54	1	0	0	0	0	1	0	0	0	8726	942	33	1	1358	1	LEO1	15	52258074	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	9566299	52258074	50273318	751	15529										
RNF111	54778	broad.mit.edu	37	chr15	59358969	59358969	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttttctgtttcaagatgactCaaggagaactacatctagtg	8	7	4	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:59358969C>G	uc002afv.2	+	6	1652	c.1373C>G	c.(1372-1374)TCA>TGA	p.S458*	RNF111_uc002afs.2_Nonsense_Mutation_p.S458*|RNF111_uc002aft.2_Nonsense_Mutation_p.S458*|RNF111_uc002afu.2_Nonsense_Mutation_p.S458*|RNF111_uc002afw.2_Nonsense_Mutation_p.S458*|RNF111_uc002afx.2_5'UTR	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	458	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		CAAGATGACTCAAGGAGAACT	0.398													0	0	0	0.007291	0	23	38										G	59358969	C	G	59358969	4	3	54	1	0	0	0	0	0	1	0	0	13425	838	29	1	1391	1	RNF111	15	59358969	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7100895	59358969	43172423	752	15530										
PDCD7	10081	broad.mit.edu	37	chr15	65426045	65426045	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcggcggtggcggacagccGaaaggagcaggaggcggcgg	22	9	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:65426045G>T	uc002aol.2	-	1	130	c.75C>A	c.(73-75)TTC>TTA	p.F25L		NM_005707	NP_005698	Q8N8D1	PDCD7_HUMAN	programmed cell death 7	25	Pro-rich.				apoptosis|induction of apoptosis|response to glucocorticoid stimulus	U12-type spliceosomal complex					0						GCGGACAGCCGAAAGGAGCAG	0.726													1	0	0.000602214	0.000602	0.000616972	4	6										T	65426045	G	T	65426045	3	4	54	1	0	0	0	0	1	0	0	0	11625	1049	37	3	1402	3	PDCD7	15	65426045	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6067076	65426045	37105347	753	15531										
C15orf27	123591	broad.mit.edu	37	chr15	76463343	76463343	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcctctcacaggtgtttgacGgggctgtgatcatcctatct	10	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:76463343G>A	uc002bbq.2	+	7	678	c.523G>A	c.(523-525)GGG>AGG	p.G175R	C15orf27_uc010bkp.2_5'UTR|C15orf27_uc002bbr.2_5'UTR	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	175	Helical; (Potential).					integral to membrane					0						GGTGTTTGACGGGGCTGTGAT	0.617													0	0	0	0.004656	0	20	19										A	76463343	G	A	76463343	3	1	54	1	0	0	0	0	1	0	0	0	1788	1116	39	2	545	2	C15orf27	15	76463343	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	11037298	76463343	26068049	754	15532										
IREB2	3658	broad.mit.edu	37	chr15	78790409	78790409	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtattcagcgtgattgcttCgtttgaagatgatgtggaaa	12	4	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:78790409C>T	uc002bdr.2	+	22	2978	c.2816C>T	c.(2815-2817)TCG>TTG	p.S939L	IREB2_uc010unb.1_Missense_Mutation_p.S689L	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	939							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		GTGATTGCTTCGTTTGAAGAT	0.358													0	0	0	0.00499	0	15	87										T	78790409	C	T	78790409	3	4	54	1	0	0	0	0	1	0	0	0	7826	893	31	1	2902	1	IREB2	15	78790409	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2327066	78790409	23740983	755	15533										
PDE8A	5151	broad.mit.edu	37	chr15	85619974	85619974	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tattttgaagggtggatagaGaagagttgtccgtaatgcct	13	4	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:85619974G>C	uc002blh.2	+	5	691	c.502G>C	c.(502-504)GAA>CAA	p.E168Q	PDE8A_uc002bli.2_Missense_Mutation_p.E168Q|PDE8A_uc010bnc.2_5'UTR|PDE8A_uc010bnd.2_5'UTR|PDE8A_uc002blj.2_5'UTR|PDE8A_uc002blk.2_5'UTR	NM_002605	NP_002596	O60658	PDE8A_HUMAN	phosphodiesterase 8A isoform 1	168					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			GGTGGATAGAGAAGAGTTGTC	0.289													0	0	0	0.010729	0	9	103										C	85619974	G	C	85619974	3	2	54	1	0	0	0	0	1	0	0	0	11653	943	33	1	520	1	PDE8A	15	85619974	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6829565	85619974	16911418	756	15534										
MFGE8	4240	broad.mit.edu	37	chr15	89449884	89449884	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttttattaacatcatggatGaaatcgaattcgtgtccatt	6	6	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:89449884G>A	uc002bng.3	-	4	626	c.513C>T	c.(511-513)TTC>TTT	p.F171F	MFGE8_uc002bnf.3_Silent_p.F59F|MFGE8_uc002bnh.3_Silent_p.F171F|MFGE8_uc010bnn.2_Silent_p.F163F|MFGE8_uc010upq.1_Silent_p.F127F|MFGE8_uc010upr.1_Silent_p.F171F|MFGE8_uc010bno.2_Silent_p.F127F	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	171	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					CATCATGGATGAAATCGAATT	0.512													0	0	0	0.005443	0	23	94										A	89449884	G	A	89449884	2	1	54	1	0	0	0	0	0	0	0	1	9520	1281	45	1		1	MFGE8	15	89449884	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3829910	89449884	13081508	757	15535										
FES	2242	broad.mit.edu	37	chr15	91433455	91433455	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggagcacctgggccccggcGagcccccgcctgtgctgctc	14	18	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:91433455G>A	uc002bpv.2	+	9	1279	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K	FES_uc010uqj.1_Missense_Mutation_p.E337K|FES_uc010uqk.1_Missense_Mutation_p.E377K|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.E337K|FES_uc002bpx.2_Missense_Mutation_p.E395K|FES_uc002bpy.2_Missense_Mutation_p.E337K	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	395					axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GGGCCCCGGCGAGCCCCCGCC	0.716													0	0	0	0.003163	0	13	79										A	91433455	G	A	91433455	3	1	54	1	0	0	0	0	1	0	0	0	5820	1059	37	1	1213	1	FES	15	91433455	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1983571	91433455	11097937	758	15536										
CHD2	1106	broad.mit.edu	37	chr15	93486105	93486105	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctactactgtatatgcgattGaagctaatggcgaccctagt	9	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:93486105G>C	uc002bsp.2	+	9	1434	c.859G>C	c.(859-861)GAA>CAA	p.E287Q	CHD2_uc002bsm.1_Missense_Mutation_p.E287Q|CHD2_uc002bsn.2_Missense_Mutation_p.E287Q|CHD2_uc002bso.1_Missense_Mutation_p.E287Q|CHD2_uc010urb.1_Missense_Mutation_p.E300Q|CHD2_uc010bof.1_RNA	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	287	Chromo 1.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATATGCGATTGAAGCTAATGG	0.418													0	0	0	0.010729	0	8	58										C	93486105	G	C	93486105	3	2	54	1	0	0	0	0	1	0	0	0	3325	1291	45	1	889	1	CHD2	15	93486105	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2052650	93486105	9045287	759	15537										
CHD2	1106	broad.mit.edu	37	chr15	93522446	93522446	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaagaagatggtattagatCatctggtgattcagcgcatg	11	5	3	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:93522446C>T	uc002bsp.2	+	22	3384	c.2809C>T	c.(2809-2811)CAT>TAT	p.H937Y	CHD2_uc002bso.1_Missense_Mutation_p.H937Y|CHD2_uc010bog.1_3'UTR|CHD2_uc010boh.1_Missense_Mutation_p.H131Y	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	937	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GGTATTAGATCATCTGGTGAT	0.473													0	0	0	0.00361	0	59	219										T	93522446	C	T	93522446	3	4	54	1	0	0	0	0	1	0	0	0	3325	826	29	1	2895	1	CHD2	15	93522446	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	36341	93522446	9008946	760	15538										
CHD2	1106	broad.mit.edu	37	chr15	93527686	93527686	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagagcggcagaaggagctaGaagaaatttatatgctgcct	12	6	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:93527686G>C	uc002bsp.2	+	25	3768	c.3193G>C	c.(3193-3195)GAA>CAA	p.E1065Q	CHD2_uc002bso.1_Missense_Mutation_p.E1065Q	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1065	Glu-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GAAGGAGCTAGAAGAAATTTA	0.408													0	0	0	0.001984	0	6	24										C	93527686	G	C	93527686	3	2	54	1	0	0	0	0	1	0	0	0	3325	943	33	1	3291	1	CHD2	15	93527686	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5240	93527686	9003706	761	15539										
MCTP2	55784	broad.mit.edu	37	chr15	94986184	94986184	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgacgaggaggatgaagatGacaaggtgcgtatgttcaag	15	4	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:94986184G>C	uc002btj.2	+	18	2310	c.2245G>C	c.(2245-2247)GAC>CAC	p.D749H	MCTP2_uc010boj.2_Missense_Mutation_p.D478H|MCTP2_uc010bok.2_Intron|MCTP2_uc002btl.2_Missense_Mutation_p.D337H	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	749					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GGATGAAGATGACAAGGTGCG	0.383													0	0	0	0.00308	0	8	64										C	94986184	G	C	94986184	3	2	54	1	0	0	0	0	1	0	0	0	9401	1290	45	1	2391	1	MCTP2	15	94986184	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1458498	94986184	7545208	762	15540										
LRRC28	123355	broad.mit.edu	37	chr15	99892583	99892583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttctaatccagatttaggtcGatctcgagaactacagtatg	8	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:99892583G>A	uc002bva.1	+	7	757	c.602G>A	c.(601-603)CGA>CAA	p.R201Q	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Missense_Mutation_p.R47Q|LRRC28_uc010urt.1_Missense_Mutation_p.R15Q|LRRC28_uc002bvc.1_Missense_Mutation_p.R201Q|LRRC28_uc010uru.1_Missense_Mutation_p.R132Q|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	201	LRR 8.										0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			GATTTAGGTCGATCTCGAGAA	0.348													0	0	0	0.003163	0	12	106										A	99892583	G	A	99892583	3	1	54	1	0	0	0	0	1	0	0	0	8982	1058	37	1	624	1	LRRC28	15	99892583	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4906399	99892583	2638809	763	15541										
LRRK1	79705	broad.mit.edu	37	chr15	101566280	101566280	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgtgcctatgtgctggcactCtgccgctccccctccggctc	10	19	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr15:101566280C>G	uc002bwr.2	+	17	2662	c.2343C>G	c.(2341-2343)CTC>CTG	p.L781L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	781	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGCTGGCACTCTGCCGCTCCC	0.597													0	0	0	0.009535	0	25	129										G	101566280	C	G	101566280	2	3	54	1	0	0	0	0	0	0	0	1	9032	900	32	1		1	LRRK1	15	101566280	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1673697	101566280	965112	764	15542										
RAB40C	57799	broad.mit.edu	37	chr16	676021	676021	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcatgaccttctttgaggtCagccccctgtgcaacttcaa	8	13	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:676021C>T	uc002chr.2	+	5	581	c.465C>T	c.(463-465)GTC>GTT	p.V155V	RAB40C_uc002chq.2_Silent_p.V136V	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	155					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)				TCTTTGAGGTCAGCCCCCTGT	0.607													0	0	0	0.00333	0	21	142										T	676021	C	T	676021	2	4	54	1	0	0	0	0	0	0	0	1	12942	813	29	1		1	RAB40C	16	676021	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08		676021	89678732	765	15543										
PTX4	390667	broad.mit.edu	37	chr16	1536456	1536456	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggagggtgcccaggcggccGgaggccgtgcggacccagct	19	13	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:1536456G>A	uc010uvf.1	-	3	906	c.906C>T	c.(904-906)TCC>TCT	p.S302S		NM_001013658	NP_001013680	Q96A99	PTX4_HUMAN	neuronal pentraxin II-like	307	Pentaxin.					extracellular region	metal ion binding				0						CCAGGCGGCCGGAGGCCGTGC	0.647													0	0	0	0.008871	0	17	62										A	1536456	G	A	1536456	2	1	54	1	0	0	0	0	0	0	0	1	12823	1103	39	2		2	PTX4	16	1536456	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	860435	1536456	88818297	766	15544										
IFT140	9742	broad.mit.edu	37	chr16	1575300	1575300	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacagcatcctgggcacctcGaagcggtgcgtgtccgactt	13	13	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:1575300G>A	uc002cmb.2	-	22	3158	c.2796C>T	c.(2794-2796)TTC>TTT	p.F932F	IFT140_uc002clz.2_Silent_p.F545F	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	932	TPR 3.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGGGCACCTCGAAGCGGTGCG	0.627													0	0	0	0.00333	0	18	135										A	1575300	G	A	1575300	2	1	54	1	0	0	0	0	0	0	0	1	7556	1049	37	1		1	IFT140	16	1575300	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	38844	1575300	88779453	767	15545										
AMDHD2	51005	broad.mit.edu	37	chr16	2578543	2578543	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaagtggaagtggacggtcTgacggcctacgtggcaggtg	19	7	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2578543T>C	uc002cqq.2	+	8	1050	c.953T>C	c.(952-954)CTG>CCG	p.L318P	AMDHD2_uc002cqp.2_Missense_Mutation_p.L318P|AMDHD2_uc010uwc.1_Missense_Mutation_p.L318P|AMDHD2_uc010uwd.1_Missense_Mutation_p.L82P	NM_015944	NP_057028	Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2 isoform 1	318					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			skin(2)|large_intestine(1)|breast(1)	4						GTGGACGGTCTGACGGCCTAC	0.701													0	0	0	0.000602	0	5	65										C	2578543	T	C	2578543	3	2	54	1	0	0	0	0	1	0	0	0	568	1580	55	5	983	5	AMDHD2	16	2578543	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	1003243	2578543	87776210	768	15546										
SRRM2	23524	broad.mit.edu	37	chr16	2811715	2811715	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agccagtgaaccccccatctGaggcctctccaactcgggac	9	17	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2811715G>A	uc002crk.2	+	11	1735	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	SRRM2_uc002crj.1_Missense_Mutation_p.E300K|SRRM2_uc002crl.1_Missense_Mutation_p.E396K|SRRM2_uc010bsu.1_Missense_Mutation_p.E300K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	396	Pro-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCCCCCATCTGAGGCCTCTCC	0.607													0	0	0	0.00632	0	21	142										A	2811715	G	A	2811715	3	1	54	1	0	0	0	0	1	0	0	0	15168	1291	45	1	1224	1	SRRM2	16	2811715	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	233172	2811715	87543038	769	15547										
SRRM2	23524	broad.mit.edu	37	chr16	2812166	2812166	+	Missense_Mutation	SNP	G	G	C													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accaggctggtctaggagcaGaaatacccagagaagaggca							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2812166G>C	uc002crk.2	+	11	2186	c.1637G>C	c.(1636-1638)AGA>ACA	p.R546T	SRRM2_uc002crj.1_Missense_Mutation_p.R450T|SRRM2_uc002crl.1_Missense_Mutation_p.R546T|SRRM2_uc010bsu.1_Missense_Mutation_p.R450T	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	546	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCTAGGAGCAGAAATACCCAG	0.597													0	0	0	0.001168	0	4	31										C	2812166	G	C	2812166	3	2	54	1	0	0	0	0	1	0	0	0	15168	942	33	1	1675	1	SRRM2	16	2812166	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	451	2812166	87542587	770	15548	76	2								
SRRM2	23524	broad.mit.edu	37	chr16	2812176	2812176	+	Silent	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctaggagcagaaatacccaGagaagaggcaggtctaggtc							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2812176G>A	uc002crk.2	+	11	2196	c.1647G>A	c.(1645-1647)CAG>CAA	p.Q549Q	SRRM2_uc002crj.1_Silent_p.Q453Q|SRRM2_uc002crl.1_Silent_p.Q549Q|SRRM2_uc010bsu.1_Silent_p.Q453Q	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	549	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GAAATACCCAGAGAAGAGGCA	0.612													0	0	0	0.001984	0	5	31										A	2812176	G	A	2812176	2	1	54	1	0	0	0	0	0	0	0	1	15168	933	33	1		1	SRRM2	16	2812176	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	10	2812176	87542577	771	15549	76	2								
SRRM2	23524	broad.mit.edu	37	chr16	2812362	2812362	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggtctagaacaccagcccgGaggggcaggtctcggtctag	15	12	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2812362G>C	uc002crk.2	+	11	2382	c.1833G>C	c.(1831-1833)CGG>CGC	p.R611R	SRRM2_uc002crj.1_Silent_p.R515R|SRRM2_uc002crl.1_Silent_p.R611R|SRRM2_uc010bsu.1_Silent_p.R515R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	611	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CACCAGCCCGGAGGGGCAGGT	0.622													0	0	0	0.001168	0	6	85										C	2812362	G	C	2812362	2	2	54	1	0	0	0	0	0	0	0	1	15168	1161	41	1		1	SRRM2	16	2812362	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	186	2812362	87542391	772	15550										
SRRM2	23524	broad.mit.edu	37	chr16	2814751	2814751	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcatctcttcacctgtgcttGatgctgtacccagaacaccc	7	15	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2814751G>C	uc002crk.2	+	11	4771	c.4222G>C	c.(4222-4224)GAT>CAT	p.D1408H	SRRM2_uc002crj.1_Missense_Mutation_p.D1312H|SRRM2_uc002crl.1_Missense_Mutation_p.D1408H|SRRM2_uc010bsu.1_Missense_Mutation_p.D1312H	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1408	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						ACCTGTGCTTGATGCTGTACC	0.473													0	0	0	0.010771	0	39	226										C	2814751	G	C	2814751	3	2	54	1	0	0	0	0	1	0	0	0	15168	1290	45	1	4260	1	SRRM2	16	2814751	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2389	2814751	87540002	773	15551										
PRSS33	260429	broad.mit.edu	37	chr16	2835105	2835105	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgcccacgtggtagaggccGtcgcaggtgcgcgagtccag	17	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:2835105G>A	uc002cro.1	-	5	742	c.582C>T	c.(580-582)GAC>GAT	p.D194D	PRSS33_uc002crp.1_Missense_Mutation_p.R104W|PRSS33_uc010uwh.1_Silent_p.D194D	NM_152891	NP_690851	Q8NF86	PRS33_HUMAN	protease, serine, 33 precursor	194	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0						GGTAGAGGCCGTCGCAGGTGC	0.687													0	0	0	0.009096	0	3	11										A	2835105	G	A	2835105	2	1	54	1	0	0	0	0	0	0	0	1	12623	1136	40	2		2	PRSS33	16	2835105	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	20354	2835105	87519648	774	15552										
ZNF213	7760	broad.mit.edu	37	chr16	3191255	3191255	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacaccggtgagcggcccttCggctgcggagagtgcgacaa	15	13	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:3191255C>T	uc010uws.1	+	6	1734	c.1287C>T	c.(1285-1287)TTC>TTT	p.F429F	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Silent_p.F429F|ZNF213_uc010uwt.1_3'UTR|uc002cuf.1_5'Flank	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	429	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCGGCCCTTCGGCTGCGGAG	0.672													0	0	0	0.001855	0	11	99										T	3191255	C	T	3191255	2	4	54	1	0	0	0	0	0	0	0	1	17766	883	31	1		1	ZNF213	16	3191255	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	356150	3191255	87163498	775	15553										
ZNF200	7752	broad.mit.edu	37	chr16	3274032	3274032	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgcagatgaagcacaaactCctcattctttgggaaggttt	9	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:3274032C>T	uc002cuj.2	-	5	1680	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K	ZNF200_uc002cum.3_Missense_Mutation_p.E349K|ZNF200_uc010bti.2_Missense_Mutation_p.E349K|ZNF200_uc002cuk.2_Missense_Mutation_p.E350K|ZNF200_uc002cui.2_Missense_Mutation_p.E349K|ZNF200_uc002cul.3_Missense_Mutation_p.E349K	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	350	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AGCACAAACTCCTCATTCTTT	0.448													0	0	0	0.004007	0	14	153										T	3274032	C	T	3274032	3	4	54	1	0	0	0	0	1	0	0	0	17759	864	30	1	143	1	ZNF200	16	3274032	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	82777	3274032	87080721	776	15554										
TFAP4	7023	broad.mit.edu	37	chr16	4310139	4310139	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatgtggaaacagagttgatGaccgaggaggggcccatggt	17	6	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:4310139G>A	uc010uxg.1	-	6	1028	c.774C>T	c.(772-774)GTC>GTT	p.V258V		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	258					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CAGAGTTGATGACCGAGGAGG	0.622													0	0	0	0.005443	0	24	172										A	4310139	G	A	4310139	2	1	54	1	0	0	0	0	0	0	0	1	15789	1277	45	1		1	TFAP4	16	4310139	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1036107	4310139	86044614	777	15555										
PPL	5493	broad.mit.edu	37	chr16	4934113	4934113	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctcttgagcctctggatctCttgctcggtgtcgcccttct	10	14	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:4934113C>G	uc002cyd.1	-	22	4633	c.4543G>C	c.(4543-4545)GAG>CAG	p.E1515Q		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1515	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						CTCTGGATCTCTTGCTCGGTG	0.637													0	0	0	0.004482	0	8	48										G	4934113	C	G	4934113	3	3	54	1	0	0	0	0	1	0	0	0	12334	922	32	1	731	1	PPL	16	4934113	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	623974	4934113	85420640	778	15556			5	62		5	5	4903	N	G_C	3.416985e-05
PPL	5493	broad.mit.edu	37	chr16	4934819	4934819	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctggggtttggtgtctttCagggcctggatttccttttt	12	8	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:4934819C>T	uc002cyd.1	-	22	3927	c.3837G>A	c.(3835-3837)CTG>CTA	p.L1279L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1279	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TGGTGTCTTTCAGGGCCTGGA	0.532													0	0	0	0.003271	0	27	132										T	4934819	C	T	4934819	2	4	54	1	0	0	0	0	0	0	0	1	12334	813	29	1		1	PPL	16	4934819	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	706	4934819	85419934	779	15557			5	62		5	5	4903	N	G_C	3.416985e-05
PPL	5493	broad.mit.edu	37	chr16	4934921	4934921	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgagccgctgaagctccttCtccatctcagggtcagtctt	9	14	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:4934921C>T	uc002cyd.1	-	22	3825	c.3735G>A	c.(3733-3735)GAG>GAA	p.E1245E		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1245	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GAAGCTCCTTCTCCATCTCAG	0.532													0	0	0	0.008291	0	10	70										T	4934921	C	T	4934921	2	4	54	1	0	0	0	0	0	0	0	1	12334	912	32	1		1	PPL	16	4934921	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	102	4934921	85419832	780	15558			5	62		5	5	4903	N	G_C	3.416985e-05
PPL	5493	broad.mit.edu	37	chr16	4935359	4935359	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcccgctccttctctagcctCttgagcttgtcctggaggaa	10	14	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:4935359C>T	uc002cyd.1	-	22	3387	c.3297G>A	c.(3295-3297)AAG>AAA	p.K1099K		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1099	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TCTCTAGCCTCTTGAGCTTGT	0.632													0	0	0	0.008871	0	17	114										T	4935359	C	T	4935359	2	4	54	1	0	0	0	0	0	0	0	1	12334	912	32	1		1	PPL	16	4935359	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	438	4935359	85419394	781	15559			5	62		5	5	4903	N	G_C	3.416985e-05
PPL	5493	broad.mit.edu	37	chr16	4939015	4939015	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tactgctgggaattggcacaGatcttctgtacttcctgctc	9	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:4939015G>C	uc002cyd.1	-	19	2451	c.2361C>G	c.(2359-2361)ATC>ATG	p.I787M		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	787	Spectrin 4.|Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						AATTGGCACAGATCTTCTGTA	0.448													0	0	0	0.00361	0	55	485										C	4939015	G	C	4939015	3	2	54	1	0	0	0	0	1	0	0	0	12334	932	33	1	2925	1	PPL	16	4939015	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3656	4939015	85415738	782	15560			5	62		5	5	4903	N	G_C	3.416985e-05
FAM86A	196483	broad.mit.edu	37	chr16	5145479	5145479	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caaaatatcccgcagcagctCagaatctgatgagtctctta	7	11	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:5145479C>T	uc002cyo.2	-	2	182	c.133G>A	c.(133-135)GAG>AAG	p.E45K	FAM86A_uc002cyp.2_Missense_Mutation_p.E45K	NM_201400	NP_958802	Q96G04	FA86A_HUMAN	hypothetical protein LOC196483 isoform 1	45											0						CGCAGCAGCTCAGAATCTGAT	0.478													0	0	0	0.006122	0	14	79										T	5145479	C	T	5145479	3	4	54	1	0	0	0	0	1	0	0	0	5643	835	29	1	887	1	FAM86A	16	5145479	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	206464	5145479	85209274	783	15561										
ATF7IP2	80063	broad.mit.edu	37	chr16	10576009	10576009	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcagtttttagcttccaacaGatactattttactgtccaat	4	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:10576009G>A	uc002czu.2	+	12	2179	c.1952G>A	c.(1951-1953)AGA>AAA	p.R651K	ATF7IP2_uc002czv.2_3'UTR|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Missense_Mutation_p.R195K|ATF7IP2_uc002czw.2_Missense_Mutation_p.R651K|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	651	Fibronectin type-III.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GCTTCCAACAGATACTATTTT	0.338													0	0	0	0.004482	0	7	47										A	10576009	G	A	10576009	3	1	54	1	0	0	0	0	1	0	0	0	1088	942	33	1	1990	1	ATF7IP2	16	10576009	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5430530	10576009	79778744	784	15562										
RUNDC2A	84127	broad.mit.edu	37	chr16	12145758	12145758	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaagtgaccaacataatctCatttgatgatgaggaagatg	10	5	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:12145758C>T	uc002dbw.1	+	8	865	c.803C>T	c.(802-804)TCA>TTA	p.S268L	SNX29_uc002dby.3_5'Flank	NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	268										ovary(1)	1						AACATAATCTCATTTGATGAT	0.433			T	CIITA	PMBL|Hodgkin Lymphona|								0	0	0	0.010729	0	8	45										T	12145758	C	T	12145758	3	4	54	1	0	0	0	0	1	0	0	0	13743	838	29	1	833	1	RUNDC2A	16	12145758	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1569749	12145758	78208995	785	15563										
DNAH3	55567	broad.mit.edu	37	chr16	20999081	20999081	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagaagtcccgcaggttaaaGacgtaatgtgacttcgaggg	14	7	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:20999081G>C	uc010vbe.1	-	46	6816	c.6816C>G	c.(6814-6816)GTC>GTG	p.V2272V	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2272	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCAGGTTAAAGACGTAATGTG	0.483													0	0	0	0.00245	0	13	78										C	20999081	G	C	20999081	2	2	54	1	0	0	0	0	0	0	0	1	4603	929	33	1		1	DNAH3	16	20999081	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	8853323	20999081	69355672	786	15564										
AQP8	343	broad.mit.edu	37	chr16	25232864	25232864	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctcctcccgtactgggtctCacagctgctcggggggatgc	14	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:25232864C>G	uc002doc.2	+	3	429	c.347C>G	c.(346-348)TCA>TGA	p.S116*		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8	116	Helical; (Potential).				cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		TACTGGGTCTCACAGCTGCTC	0.627													0	0	0	0.003755	0	26	214										G	25232864	C	G	25232864	4	3	54	1	0	0	0	0	0	1	0	0	832	838	29	1	357	1	AQP8	16	25232864	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4233783	25232864	65121889	787	15565										
SRCAP	10847	broad.mit.edu	37	chr16	30715622	30715622	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agagccatgccgaaattgcaGaacaggccaagcatgtacgt	11	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:30715622G>A	uc002dze.1	+	4	677	c.292G>A	c.(292-294)GAA>AAA	p.E98K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	98					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CGAAATTGCAGAACAGGCCAA	0.493													0	0	0	0.006999	0	31	178										A	30715622	G	A	30715622	3	1	54	1	0	0	0	0	1	0	0	0	15134	943	33	1	298	1	SRCAP	16	30715622	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5482758	30715622	59639131	788	15566										
STX4	6810	broad.mit.edu	37	chr16	31049270	31049270	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggggtcctgtcccagcaattCgtggagctcatcaacaagtg	12	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:31049270C>T	uc002eal.2	+	6	626	c.402C>T	c.(400-402)TTC>TTT	p.F134F	STX4_uc002eak.2_Silent_p.F132F|STX4_uc002eam.2_Silent_p.F56F	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	134	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						CCCAGCAATTCGTGGAGCTCA	0.547													0	0	0	0.010729	0	10	106										T	31049270	C	T	31049270	2	4	54	1	0	0	0	0	0	0	0	1	15346	883	31	1		1	STX4	16	31049270	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	333648	31049270	59305483	789	15567										
ITGAM	3684	broad.mit.edu	37	chr16	31309204	31309204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccattggggccccaggagagGaggacaaccggggtgctgtt	17	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:31309204G>A	uc002ebq.2	+	14	1734	c.1636G>A	c.(1636-1638)GAG>AAG	p.E546K	ITGAM_uc002ebr.2_Missense_Mutation_p.E547K|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Intron	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	546	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CCCAGGAGAGGAGGACAACCG	0.617													0	0	0	0.008871	0	19	158										A	31309204	G	A	31309204	3	1	54	1	0	0	0	0	1	0	0	0	7887	1175	41	1	1693	1	ITGAM	16	31309204	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	259934	31309204	59045549	790	15568										
ARMC5	79798	broad.mit.edu	37	chr16	31473868	31473868	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggtagatgagctccggcagCgccgggatcctaatggagct	15	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:31473868C>T	uc002ecc.2	+	3	1529	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C	ARMC5_uc010vfn.1_Missense_Mutation_p.R429C|ARMC5_uc010vfo.1_Missense_Mutation_p.R366C|ARMC5_uc002eca.3_Missense_Mutation_p.R334C|ARMC5_uc010vfp.1_Intron|ARMC5_uc002ecb.2_Missense_Mutation_p.R334C	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	334	ARM 5.						binding			pancreas(1)	1						GCTCCGGCAGCGCCGGGATCC	0.647													0	0	0	0.008871	0	16	121										T	31473868	C	T	31473868	3	4	54	1	0	0	0	0	1	0	0	0	954	768	27	2	1010	2	ARMC5	16	31473868	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	164664	31473868	58880885	791	15569										
SLC5A2	6524	broad.mit.edu	37	chr16	31499002	31499002	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taccacctgctccggcacccCgtgaccggggatctgccgtg	12	17	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:31499002C>T	uc002ecf.3	+	7	826	c.807C>T	c.(805-807)CCC>CCT	p.P269P	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	269	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						TCCGGCACCCCGTGACCGGGG	0.667													0	0	0	0.010504	0	17	80										T	31499002	C	T	31499002	2	4	54	1	0	0	0	0	0	0	0	1	14665	639	23	2		2	SLC5A2	16	31499002	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	25134	31499002	58855751	792	15570										
ABCC12	94160	broad.mit.edu	37	chr16	48177916	48177916	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctttcaccatcaccggcgtGagccaggaaaatgtggcgaa	11	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:48177916G>A	uc002efc.1	-	2	526	c.180C>T	c.(178-180)CTC>CTT	p.L60L	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Silent_p.L60L|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	60						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TCACCGGCGTGAGCCAGGAAA	0.567													0	0	0	0.00245	0	12	101										A	48177916	G	A	48177916	2	1	54	1	0	0	0	0	0	0	0	1	52	1277	45	1		1	ABCC12	16	48177916	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	16678914	48177916	42176837	793	15571										
NOD2	64127	broad.mit.edu	37	chr16	50745519	50745519	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgtgctgctacgtgttctCagcccagcagctccaggcag	11	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:50745519C>G	uc002egm.1	+	4	1802	c.1697C>G	c.(1696-1698)TCA>TGA	p.S566*	NOD2_uc010cbk.1_Nonsense_Mutation_p.S539*|NOD2_uc002egl.1_Nonsense_Mutation_p.S344*|NOD2_uc010cbl.1_Nonsense_Mutation_p.S344*|NOD2_uc010cbm.1_Nonsense_Mutation_p.S344*|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	566	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				TACGTGTTCTCAGCCCAGCAG	0.647													0	0	0	0.00308	0	6	52										G	50745519	C	G	50745519	4	3	54	1	0	0	0	0	0	1	0	0	10517	838	29	1	1711	1	NOD2	16	50745519	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2567603	50745519	39609234	794	15572										
IRX5	10265	broad.mit.edu	37	chr16	54967531	54967531	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggcgggacggtgctgtccCggcctctctactacaccgcg	13	16	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:54967531C>T	uc002ehv.2	+	3	1198	c.1198C>T	c.(1198-1200)CGG>TGG	p.R400W	IRX5_uc002ehw.2_Missense_Mutation_p.R334W	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	400					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						GGTGCTGTCCCGGCCTCTCTA	0.711													0	0	0	0.006214	0	9	39										T	54967531	C	T	54967531	3	4	54	1	0	0	0	0	1	0	0	0	7847	643	23	2	1208	2	IRX5	16	54967531	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4222012	54967531	35387222	795	15573										
GPR56	9289	broad.mit.edu	37	chr16	57695626	57695626	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggtgctggatccgggactCcctggtcagctacatcacca	11	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:57695626C>G	uc002emb.2	+	14	1992	c.1700C>G	c.(1699-1701)TCC>TGC	p.S567C	GPR56_uc002ema.1_Missense_Mutation_p.S392C|GPR56_uc002emc.2_Missense_Mutation_p.S561C|GPR56_uc002emf.2_Missense_Mutation_p.S561C|GPR56_uc010vhs.1_Missense_Mutation_p.S567C|GPR56_uc002emd.2_Missense_Mutation_p.S561C|GPR56_uc002eme.2_Missense_Mutation_p.S561C|GPR56_uc010vht.1_Missense_Mutation_p.S566C|GPR56_uc002emg.3_Missense_Mutation_p.S561C|GPR56_uc010vhu.1_Missense_Mutation_p.S386C	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	567	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						ATCCGGGACTCCCTGGTCAGC	0.552													0	0	0	0.001168	0	6	32										G	57695626	C	G	57695626	3	3	54	1	0	0	0	0	1	0	0	0	6700	855	30	1	1761	1	GPR56	16	57695626	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2728095	57695626	32659127	796	15574										
CDH11	1009	broad.mit.edu	37	chr16	64981694	64981694	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgaatggagtcataaggagGagccgtggggtcattgtctg	16	5	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:64981694G>A	uc002eoi.2	-	13	2637	c.2203C>T	c.(2203-2205)CCT>TCT	p.P735S	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Missense_Mutation_p.P609S	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	735	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCATAAGGAGGAGCCGTGGGG	0.567			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.00245	0	14	41										A	64981694	G	A	64981694	3	1	54	1	0	0	0	0	1	0	0	0	3097	1174	41	1	191	1	CDH11	16	64981694	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7286068	64981694	25373059	797	15575										
CDH11	1009	broad.mit.edu	37	chr16	65016069	65016069	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggccaagaacatagggggctCatcagcatcttctactgaga	11	10	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:65016069C>T	uc002eoi.2	-	8	1569	c.1135G>A	c.(1135-1137)GAG>AAG	p.E379K	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.E379K|CDH11_uc010vin.1_Missense_Mutation_p.E253K|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	379	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ATAGGGGGCTCATCAGCATCT	0.527			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.001984	0	5	77										T	65016069	C	T	65016069	3	4	54	1	0	0	0	0	1	0	0	0	3097	835	29	1	1279	1	CDH11	16	65016069	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	34375	65016069	25338684	798	15576										
CDH16	1014	broad.mit.edu	37	chr16	66949265	66949265	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcccggtctgaagcctcaagGaagaggaaggggatgcctgg	16	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:66949265G>T	uc002eql.2	-	6	514	c.441C>A	c.(439-441)TTC>TTA	p.F147L	CDH16_uc010cdy.2_Missense_Mutation_p.F147L|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	147	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		AAGCCTCAAGGAAGAGGAAGG	0.582													1	0	4.72057e-08	0.003954	4.96177e-08	18	75										T	66949265	G	T	66949265	3	4	54	1	0	0	0	0	1	0	0	0	3101	1165	41	3	2100	3	CDH16	16	66949265	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1933196	66949265	23405488	799	15577										
B3GNT9	84752	broad.mit.edu	37	chr16	67183434	67183434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgctgcagacacatgcccaGaaagacgtcgtcgatgggga	14	11	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:67183434G>C	uc002erf.2	-	2	1276	c.955C>G	c.(955-957)CTG>GTG	p.L319V	uc002erg.1_5'UTR	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	319	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0						CACATGCCCAGAAAGACGTCG	0.687													0	0	0	0.00308	0	5	12										C	67183434	G	C	67183434	3	2	54	1	0	0	0	0	1	0	0	0	1264	933	33	1	257	1	B3GNT9	16	67183434	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	234169	67183434	23171319	800	15578										
B3GNT9	84752	broad.mit.edu	37	chr16	67183755	67183755	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaagctgaggcccaggctaGaaagtggatctccttgagcg	14	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:67183755G>C	uc002erf.2	-	2	955	c.634C>G	c.(634-636)CTA>GTA	p.L212V	uc002erg.1_Missense_Mutation_p.R53T	NM_033309	NP_171608	Q6UX72	B3GN9_HUMAN	UDP-GlcNAc:betaGal	212	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0						GCCCAGGCTAGAAAGTGGATC	0.592													0	0	0	0.009096	0	4	15										C	67183755	G	C	67183755	3	2	54	1	0	0	0	0	1	0	0	0	1264	933	33	1	578	1	B3GNT9	16	67183755	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	321	67183755	23170998	801	15579										
ELMO3	79767	broad.mit.edu	37	chr16	67233112	67233112	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggccgcgagtgcgggacaccGaggtcaggtctcggaaaggg	19	10	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:67233112G>A	uc002esa.2	+	1	85	c.42G>A	c.(40-42)CCG>CCA	p.P14P	ELMO3_uc002esb.2_Silent_p.P14P|ELMO3_uc002esc.2_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	Error:Variant_position_missing_in_Q96BJ8_after_alignment					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GCGGGACACCGAGGTCAGGTC	0.687													0	0	0	0.001168	0	4	16										A	67233112	G	A	67233112	2	1	54	1	0	0	0	0	0	0	0	1	5067	1045	37	1		1	ELMO3	16	67233112	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	49357	67233112	23121641	802	15580										
SLC12A4	6560	broad.mit.edu	37	chr16	67985768	67985768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccggggatgccagggatctCggtcacattgttgagcatga	14	10	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:67985768C>T	uc002euz.2	-	8	1231	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	SLC12A4_uc010ceu.2_Missense_Mutation_p.E358K|SLC12A4_uc010vkh.1_Missense_Mutation_p.E333K|SLC12A4_uc010vki.1_Missense_Mutation_p.E364K|SLC12A4_uc010vkj.1_Missense_Mutation_p.E366K|SLC12A4_uc002eva.2_Missense_Mutation_p.E364K|SLC12A4_uc002evb.2_RNA	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	364	Helical; (Potential).				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCAGGGATCTCGGTCACATTG	0.607													0	0	0	0.001168	0	6	32										T	67985768	C	T	67985768	3	4	54	1	0	0	0	0	1	0	0	0	14385	893	31	1	2235	1	SLC12A4	16	67985768	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	752656	67985768	22368985	803	15581										
COG4	25839	broad.mit.edu	37	chr16	70517820	70517820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaaggcagctgtcaaacttgGcctgggcctgctcccctcca	10	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:70517820G>A	uc002ezc.2	-	14	1774	c.1763C>T	c.(1762-1764)GCC>GTC	p.A588V	COG4_uc002eza.2_5'UTR|COG4_uc002ezb.2_Missense_Mutation_p.A44V|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.A567V|COG4_uc002eze.2_Missense_Mutation_p.A282V	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	584					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				GTCAAACTTGGCCTGGGCCTG	0.582													0	0	0	0.002299	0	21	120										A	70517820	G	A	70517820	3	1	54	1	0	0	0	0	1	0	0	0	3660	1203	42	2	630	2	COG4	16	70517820	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2532052	70517820	19836933	804	15582										
COG4	25839	broad.mit.edu	37	chr16	70551628	70551628	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctttgcatctccctcaatCagctgcagattaggactgga	9	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:70551628C>T	uc002ezc.2	-	3	281	c.270G>A	c.(268-270)CTG>CTA	p.L90L	COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Silent_p.L90L|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	86	Interacts with STX5.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				CTCCCTCAATCAGCTGCAGAT	0.453													0	0	0	0.003954	0	20	112										T	70551628	C	T	70551628	2	4	54	1	0	0	0	0	0	0	0	1	3660	813	29	1		1	COG4	16	70551628	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	33808	70551628	19803125	805	15583										
HYDIN	54768	broad.mit.edu	37	chr16	71220736	71220736	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accttgctttgaaatcctttGaacatattgaccaatcccat	4	11	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:71220736G>C	uc002ezr.2	-	2	191	c.63C>G	c.(61-63)TTC>TTG	p.F21L	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Missense_Mutation_p.F21L|HYDIN_uc010vmc.1_Missense_Mutation_p.F38L|HYDIN_uc010vmd.1_Missense_Mutation_p.F48L|HYDIN_uc002ezw.3_Missense_Mutation_p.F38L	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	21										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GAAATCCTTTGAACATATTGA	0.383													0	0	0	0.000602	0	4	33										C	71220736	G	C	71220736	3	2	54	1	0	0	0	0	1	0	0	0	7467	1281	45	1	15651	1	HYDIN	16	71220736	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	669108	71220736	19134017	806	15584										
CHST4	10164	broad.mit.edu	37	chr16	71571634	71571634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacttcagaaagcctgtggcGatgccatgaatttgctgggc	13	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:71571634G>A	uc002fan.2	+	2	1235	c.1054G>A	c.(1054-1056)GAT>AAT	p.D352N	CHST4_uc002fao.2_Missense_Mutation_p.D352N	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	352	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGCCTGTGGCGATGCCATGAA	0.512											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	47										A	71571634	G	A	71571634	3	1	54	1	0	0	0	0	1	0	0	0	3406	1058	37	1	1056	1	CHST4	16	71571634	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	350898	71571634	18783119	807	15585										
KARS	3735	broad.mit.edu	37	chr16	75681495	75681495	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttcttgctcagtttcggctCgctgccatccactttcacct	6	16	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:75681495C>T	uc002feq.2	-	1	91	c.43G>A	c.(43-45)GAG>AAG	p.E15K	KARS_uc002fer.2_5'UTR|KARS_uc002fes.2_5'UTR|KARS_uc010cha.1_Intron|TERF2IP_uc002fet.1_5'Flank	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	15				Missing: Loss of nuclear localization, but no effect on packaging into HIV-1.	interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	AGTTTCGGCTCGCTGCCATCC	0.587													0	0	0	0.004482	0	7	38										T	75681495	C	T	75681495	3	4	54	1	0	0	0	0	1	0	0	0	7980	893	31	1	1956	1	KARS	16	75681495	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4109861	75681495	14673258	808	15586										
ADAMTS18	170692	broad.mit.edu	37	chr16	77393224	77393224	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggcacttacttgtgccctGactcatgagcgatggtgaag	13	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:77393224G>A	uc002ffc.3	-	8	1732	c.1313C>T	c.(1312-1314)TCA>TTA	p.S438L	ADAMTS18_uc010chc.1_Missense_Mutation_p.S26L|ADAMTS18_uc002ffe.1_Missense_Mutation_p.S134L|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	438	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						CTTGTGCCCTGACTCATGAGC	0.463													0	0	0	0.000602	0	4	22										A	77393224	G	A	77393224	3	1	54	1	0	0	0	0	1	0	0	0	263	1294	45	1	2416	1	ADAMTS18	16	77393224	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1711729	77393224	12961529	809	15587										
ZC3H18	124245	broad.mit.edu	37	chr16	88690429	88690429	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccccacatagaccttccatCagaaccaagggagagccggc	9	15	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:88690429C>T	uc002fky.2	+	11	2057	c.1857C>T	c.(1855-1857)ATC>ATT	p.I619I	ZC3H18_uc010voz.1_Silent_p.I643I|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	619	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GACCTTCCATCAGAACCAAGG	0.672													0	0	0	0.009535	0	23	155										T	88690429	C	T	88690429	2	4	54	1	0	0	0	0	0	0	0	1	17565	816	29	1		1	ZC3H18	16	88690429	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	11297205	88690429	1664324	810	15588										
TUBB3	10381	broad.mit.edu	37	chr16	90002120	90002120	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acatgaacgacctggtgtccGagtaccagcagtaccaggac	11	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr16:90002120G>A	uc002fph.1	+	4	1326	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K	TUBB3_uc002fpf.2_Missense_Mutation_p.E768K|TUBB3_uc010ciz.1_Missense_Mutation_p.E349K|TUBB3_uc002fpg.1_Missense_Mutation_p.E275K|TUBB3_uc002fpi.1_Missense_Mutation_p.E349K|TUBB3_uc002fpj.1_Missense_Mutation_p.E349K|TUBB3_uc010cjb.1_Missense_Mutation_p.E275K|TUBB3_uc002fpk.1_Missense_Mutation_p.E275K	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	421					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCTGGTGTCCGAGTACCAGCA	0.632													0	0	0	0.003954	0	19	106										A	90002120	G	A	90002120	3	1	54	1	0	0	0	0	1	0	0	0	16754	1059	37	1	1275	1	TUBB3	16	90002120	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1311691	90002120	352633	811	15589										
OR1E2	8388	broad.mit.edu	37	chr17	3337109	3337109	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccaggagcaggaagtctgaGatgctggtttgattttgtcc	13	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:3337109G>A	uc010vre.1	-	1	27	c.27C>T	c.(25-27)ATC>ATT	p.I9I		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	9	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGAAGTCTGAGATGCTGGTTT	0.458													0	0	0	0.002299	0	9	59										A	3337109	G	A	3337109	2	1	54	1	0	0	0	0	0	0	0	1	10955	932	33	1		1	OR1E2	17	3337109	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		3337109	77858101	812	15590										
P2RX5	5026	broad.mit.edu	37	chr17	3593966	3593966	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagcacgcgccatcaggaatGccttcattctgccaggagag	12	12	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:3593966G>A	uc002fwi.2	-	4	653	c.369C>T	c.(367-369)GGC>GGT	p.G123G	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Silent_p.G123G|P2RX5_uc010vrx.1_Silent_p.G63G|P2RX5_uc002fwj.2_Silent_p.G99G|P2RX5_uc002fwk.2_Silent_p.G123G|P2RX5_uc002fwl.2_Silent_p.G99G|P2RX5_uc002fwm.1_Silent_p.G123G	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	123	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CATCAGGAATGCCTTCATTCT	0.632													0	0	0	0.003163	0	12	74										A	3593966	G	A	3593966	2	1	54	1	0	0	0	0	0	0	0	1	11343	1306	46	2		2	P2RX5	17	3593966	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	256857	3593966	77601244	813	15591										
ZZEF1	23140	broad.mit.edu	37	chr17	3936223	3936223	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtgaaggtggcaatgacatCacgccacagtggggcactgt	14	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:3936223C>T	uc002fxe.2	-	41	6722	c.6658G>A	c.(6658-6660)GAT>AAT	p.D2220N	ZZEF1_uc002fxh.2_Missense_Mutation_p.D534N|ZZEF1_uc002fxi.2_Missense_Mutation_p.D455N	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2220							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCAATGACATCACGCCACAGT	0.597													0	0	0	0.00308	0	8	35										T	3936223	C	T	3936223	3	4	54	1	0	0	0	0	1	0	0	0	18252	826	29	1	2287	1	ZZEF1	17	3936223	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	342257	3936223	77258987	814	15592										
TEKT1	83659	broad.mit.edu	37	chr17	6719158	6719158	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccgaagagtcataccgaatCtgctcggaagcctcctccaa	9	14	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:6719158C>T	uc002gdt.2	-	4	590	c.480G>A	c.(478-480)CAG>CAA	p.Q160Q	TEKT1_uc010vth.1_Silent_p.Q14Q	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	160	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				CATACCGAATCTGCTCGGAAG	0.532													0	0	0	0.000602	0	4	52										T	6719158	C	T	6719158	2	4	54	1	0	0	0	0	0	0	0	1	15749	912	32	1		1	TEKT1	17	6719158	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2782935	6719158	74476052	815	15593										
TMEM88	92162	broad.mit.edu	37	chr17	7758849	7758849	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcaccggattcctgctcctCgtgccgctgctcgtgcttgc	11	16	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:7758849C>T	uc002giy.2	+	2	306	c.297C>T	c.(295-297)CTC>CTT	p.L99L	CYB5D1_uc010cnn.1_5'Flank|CYB5D1_uc002gjb.3_5'Flank	NM_203411	NP_981956	Q6PEY1	TMM88_HUMAN	transmembrane protein 88	99	Helical; (Potential).					integral to membrane					0		all_cancers(10;0.00528)|Prostate(122;0.202)				TCCTGCTCCTCGTGCCGCTGC	0.682													0	0	0	0.00632	0	25	136										T	7758849	C	T	7758849	2	4	54	1	0	0	0	0	0	0	0	1	16209	871	31	1		1	TMEM88	17	7758849	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1039691	7758849	73436361	816	15594										
GUCY2D	3000	broad.mit.edu	37	chr17	7910802	7910802	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaagatcatcctgaccgtgGacgacatcacctttctccac	6	15	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:7910802G>T	uc002gjt.2	+	6	1596	c.1522G>T	c.(1522-1524)GAC>TAC	p.D508Y		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	508	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CCTGACCGTGGACGACATCAC	0.562													1	0	1.19451e-25	0.00361	1.29115e-25	38	189										T	7910802	G	T	7910802	3	4	54	1	0	0	0	0	1	0	0	0	6897	1174	41	3	1540	3	GUCY2D	17	7910802	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	151953	7910802	73284408	817	15595										
MYH2	4620	broad.mit.edu	37	chr17	10441042	10441042	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagtcgatgaacgtccactcGatgccttccttcttgtactc	7	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:10441042G>C	uc010coi.2	-	15	1655	c.1527C>G	c.(1525-1527)ATC>ATG	p.I509M	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.I509M|MYH2_uc010coj.2_Missense_Mutation_p.I509M	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	509	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						ACGTCCACTCGATGCCTTCCT	0.493													0	0	0	0.012319	0	17	199										C	10441042	G	C	10441042	3	2	54	1	0	0	0	0	1	0	0	0	10035	1048	37	1	4402	1	MYH2	17	10441042	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2530240	10441042	70754168	818	15596										
C17orf48	56985	broad.mit.edu	37	chr17	10608412	10608412	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcacttacagggtgccattGaagactggaataatgaaagc	10	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:10608412G>A	uc002gmt.2	+	2	244	c.169G>A	c.(169-171)GAA>AAA	p.E57K	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Missense_Mutation_p.E57K	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	57							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						GGGTGCCATTGAAGACTGGAA	0.428													0	0	0	0.001368	0	13	75										A	10608412	G	A	10608412	3	1	54	1	0	0	0	0	1	0	0	0	1859	1291	45	1	171	1	C17orf48	17	10608412	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	167370	10608412	70586798	819	15597										
PMP22	5376	broad.mit.edu	37	chr17	15162452	15162452	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtggtggacatttcctgagGaagaggtgctacagttctgc	14	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:15162452G>A	uc002goj.2	-	2	186	c.137C>T	c.(136-138)TCC>TTC	p.S46F	PMP22_uc002gok.2_Missense_Mutation_p.S46F|PMP22_uc002gol.2_Missense_Mutation_p.S46F	NM_153322	NP_696997	Q01453	PMP22_HUMAN	peripheral myelin protein 22	46					peripheral nervous system development|synaptic transmission	integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0884)|BRCA - Breast invasive adenocarcinoma(8;4.92e-06)		ATTTCCTGAGGAAGAGGTGCT	0.463													0	0	0	0.001368	0	8	75										A	15162452	G	A	15162452	3	1	54	1	0	0	0	0	1	0	0	0	12139	1174	41	1	357	1	PMP22	17	15162452	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4554040	15162452	66032758	820	15598										
TTC19	54902	broad.mit.edu	37	chr17	15902870	15902870	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accgccgccgccatctcgctCaggagctcctccacaaccgc	8	21	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:15902870C>G	uc002gph.1	+	1	89	c.71C>G	c.(70-72)TCA>TGA	p.S24*	ZSWIM7_uc002gpe.2_Silent_p.L13L|ZSWIM7_uc002gpf.2_Silent_p.L13L|ZSWIM7_uc002gpg.2_RNA|TTC19_uc010cox.1_RNA	NM_017775	NP_060245	Q6DKK2	TTC19_HUMAN	tetratricopeptide repeat domain 19	Error:Variant_position_missing_in_Q6DKK2_after_alignment					cell cycle|cytokinesis|mitochondrial respiratory chain complex III assembly	centrosome|midbody|mitochondrial inner membrane	protein binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCATCTCGCTCAGGAGCTCCT	0.746													0	0	0	0.001984	0	4	21										G	15902870	C	G	15902870	4	3	54	1	0	0	0	0	0	1	0	0	16683	838	29	1	73	1	TTC19	17	15902870	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	740418	15902870	65292340	821	15599										
NCOR1	9611	broad.mit.edu	37	chr17	16049769	16049769	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtattcccttgttttgctttCtttagctttcctccgaggat	7	10	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:16049769C>G	uc002gpo.2	-	10	1243	c.1003G>C	c.(1003-1005)GAA>CAA	p.E335Q	NCOR1_uc002gpn.2_Missense_Mutation_p.E335Q|NCOR1_uc002gpp.1_Missense_Mutation_p.E226Q|NCOR1_uc002gpr.2_Missense_Mutation_p.E226Q|NCOR1_uc002gps.1_Missense_Mutation_p.E344Q|NCOR1_uc010coz.1_Missense_Mutation_p.E151Q|NCOR1_uc010cpb.1_Missense_Mutation_p.E344Q|NCOR1_uc010cpa.1_Missense_Mutation_p.E335Q	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	335	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTTTTGCTTTCTTTAGCTTTC	0.368													0	0	0	0.008291	0	8	48										G	16049769	C	G	16049769	3	3	54	1	0	0	0	0	1	0	0	0	10235	922	32	1	6467	1	NCOR1	17	16049769	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	146899	16049769	65145441	822	15600										
RAI1	10743	broad.mit.edu	37	chr17	17700429	17700429	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtaaatgtgggcaccgggcaGaagctcccaacttctggggc	14	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:17700429G>A	uc002grm.2	+	3	4636	c.4167G>A	c.(4165-4167)CAG>CAA	p.Q1389Q	RAI1_uc002grn.1_Silent_p.Q1389Q	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1389						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GCACCGGGCAGAAGCTCCCAA	0.537													0	0	0	0.004007	0	13	79										A	17700429	G	A	17700429	2	1	54	1	0	0	0	0	0	0	0	1	13007	933	33	1		1	RAI1	17	17700429	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1650660	17700429	63494781	823	15601										
FAM83G	644815	broad.mit.edu	37	chr17	18881778	18881778	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgttggccctctccaggtGaagcagtcctgggtggatgg	15	10	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:18881778G>A	uc002guw.2	-	5	1368	c.1201C>T	c.(1201-1203)CAC>TAC	p.H401Y	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	401										ovary(1)|central_nervous_system(1)	2						CTCTCCAGGTGAAGCAGTCCT	0.637													0	0	0	0.004672	0	3	13										A	18881778	G	A	18881778	3	1	54	1	0	0	0	0	1	0	0	0	5639	1290	45	1	1278	1	FAM83G	17	18881778	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1181349	18881778	62313432	824	15602										
RNF112	7732	broad.mit.edu	37	chr17	19316427	19316427	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcagggaagtccttcctcctCaaccatttgcttcagggctt	8	13	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:19316427C>T	uc010vyw.1	+	4	757	c.558C>T	c.(556-558)CTC>CTT	p.L186L	RNF112_uc010vyu.1_Silent_p.L186L|RNF112_uc010vyv.1_Silent_p.L186L|RNF112_uc010vyx.1_Intron	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	186							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						CCTTCCTCCTCAACCATTTGC	0.682													0	0	0	0.004482	0	5	84										T	19316427	C	T	19316427	2	4	54	1	0	0	0	0	0	0	0	1	13426	813	29	1		1	RNF112	17	19316427	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	434649	19316427	61878783	825	15603										
SARM1	23098	broad.mit.edu	37	chr17	26687798	26687798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcatcaccatcttcaatttCattgtcacggtggttgctgc	8	11	6	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:26687798C>G	uc010wah.1	+	5	466	c.459C>G	c.(457-459)TTC>TTG	p.F153L	TMEM199_uc002hba.2_Missense_Mutation_p.F153L	NM_152464	NP_689677	Q6SZW1	SARM1_HUMAN	transmembrane protein 199	Error:Variant_position_missing_in_Q6SZW1_after_alignment					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TCTTCAATTTCATTGTCACGG	0.502													0	0	0	0.010504	0	14	108										G	26687798	C	G	26687798	3	3	54	1	0	0	0	0	1	0	0	0	13842	825	29	1		1	SARM1	17	26687798	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7371371	26687798	54507412	826	15604										
KIAA0100	9703	broad.mit.edu	37	chr17	26964034	26964034	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atggagagcatggaaaggctGagcactggggtagggatgtc	18	5	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:26964034G>A	uc002hbu.2	-	15	2025	c.1926C>T	c.(1924-1926)CTC>CTT	p.L642L		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	642						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TGGAAAGGCTGAGCACTGGGG	0.547													0	0	0	0.002836	0	25	155										A	26964034	G	A	26964034	2	1	54	1	0	0	0	0	0	0	0	1	8154	1277	45	1		1	KIAA0100	17	26964034	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	276236	26964034	54231176	827	15605										
ERAL1	26284	broad.mit.edu	37	chr17	27186107	27186107	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcctagaacacctgccccaGgaggtgccttacaatgtaca	8	14	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:27186107G>A	uc002hcy.1	+	8	1096	c.1086G>A	c.(1084-1086)CAG>CAA	p.Q362Q	ERAL1_uc002hcz.1_RNA|ERAL1_uc002hda.1_Silent_p.Q169Q|ERAL1_uc002hdb.1_Silent_p.Q245Q	NM_005702	NP_005693	O75616	ERAL1_HUMAN	Era-like 1	362	KH type-2.				ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			skin(1)	1	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			ACCTGCCCCAGGAGGTGCCTT	0.527													0	0	0	0.004007	0	13	110										A	27186107	G	A	27186107	2	1	54	1	0	0	0	0	0	0	0	1	5202	991	35	2		2	ERAL1	17	27186107	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	222073	27186107	54009103	828	15606										
MYO18A	399687	broad.mit.edu	37	chr17	27419972	27419972	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcagggccttggtgcgcttCaggtccttccgcagccgctt	13	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:27419972C>T	uc002hdt.1	-	33	5132	c.4974G>A	c.(4972-4974)CTG>CTA	p.L1658L	MYO18A_uc010wbc.1_Silent_p.L1191L|MYO18A_uc002hds.2_Silent_p.L1200L|MYO18A_uc010csa.1_Silent_p.L1621L|MYO18A_uc002hdu.1_Silent_p.L1658L	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1658	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGGTGCGCTTCAGGTCCTTCC	0.617													0	0	0	0.001368	0	13	68										T	27419972	C	T	27419972	2	4	54	1	0	0	0	0	0	0	0	1	10065	813	29	1		1	MYO18A	17	27419972	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	233865	27419972	53775238	829	15607										
CORO6	84940	broad.mit.edu	37	chr17	27943163	27943163	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggctccgggcctggcgtatCcgggtacagatcgtcctgga	15	13	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:27943163C>T	uc002hel.2	-	9	1095	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	CORO6_uc002hem.2_Missense_Mutation_p.D131N|CORO6_uc002hen.2_Missense_Mutation_p.D131N	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	365					actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CCTGGCGTATCCGGGTACAGA	0.672													0	0	0	0.003163	0	14	96										T	27943163	C	T	27943163	3	4	54	1	0	0	0	0	1	0	0	0	3758	855	30	1	333	1	CORO6	17	27943163	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	523191	27943163	53252047	830	15608										
BLMH	642	broad.mit.edu	37	chr17	28593921	28593921	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctttgtggccatggtcttCaccccatgaattctccactc	6	15	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:28593921C>T	uc002hez.1	-	11	1435	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	BLMH_uc010wbn.1_Missense_Mutation_p.E313K	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	400					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						CCATGGTCTTCACCCCATGAA	0.493													0	0	0	0.000602	0	4	70										T	28593921	C	T	28593921	3	4	54	1	0	0	0	0	1	0	0	0	1446	835	29	1	177	1	BLMH	17	28593921	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	650758	28593921	52601289	831	15609										
TBC1D29	26083	broad.mit.edu	37	chr17	28890294	28890294	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcaagcgctgacagcctcaGagagcagcagaggcccctca	12	14	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:28890294G>A	uc002hfh.2	+	5	453	c.304G>A	c.(304-306)GAG>AAG	p.E102K	TBC1D29_uc002hfi.2_RNA	NM_015594	NP_056409	Q9UFV1	TBC29_HUMAN	TBC1 domain family, member 29	102						intracellular	Rab GTPase activator activity				0		Myeloproliferative disorder(56;0.0255)				GACAGCCTCAGAGAGCAGCAG	0.597													0	0	0	0.001984	0	6	45										A	28890294	G	A	28890294	3	1	54	1	0	0	0	0	1	0	0	0	15615	943	33	1	322	1	TBC1D29	17	28890294	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	296373	28890294	52304916	832	15610										
NF1	4763	broad.mit.edu	37	chr17	29490350	29490350	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctggggttttattttctctCagctgcaacaacttcaatgc	7	10	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:29490350C>T	uc002hgg.2	+	4	768	c.435C>T	c.(433-435)CTC>CTT	p.L145L	NF1_uc002hge.1_Silent_p.L145L|NF1_uc002hgf.1_Silent_p.L145L|NF1_uc002hgh.2_Silent_p.L145L|NF1_uc010csn.1_Missense_Mutation_p.S41L	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	145			L -> P (in NF1).		actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(5)|p.?(4)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TATTTTCTCTCAGCTGCAACA	0.418			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.006214	0	7	45										T	29490350	C	T	29490350	2	4	54	1	0	0	0	0	0	0	0	1	10356	813	29	1		1	NF1	17	29490350	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	600056	29490350	51704860	833	15611										
RAB11FIP4	84440	broad.mit.edu	37	chr17	29849000	29849000	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgctagatgtttactgctctCaatgctgcaagaaaatcaac	7	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:29849000C>T	uc002hgn.1	+	6	1055	c.826C>T	c.(826-828)CAA>TAA	p.Q276*	RAB11FIP4_uc002hgo.2_Nonsense_Mutation_p.Q174*	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	276	Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				TTACTGCTCTCAATGCTGCAA	0.527													0	0	0	0.002299	0	19	141										T	29849000	C	T	29849000	4	4	54	1	0	0	0	0	0	1	0	0	12896	827	29	1	848	1	RAB11FIP4	17	29849000	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	358650	29849000	51346210	834	15612										
RHOT1	55288	broad.mit.edu	37	chr17	30503214	30503214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gattcctctcataaatgaaaGaacagacaaagacagcaggt	8	8	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:30503214G>A	uc002hgz.2	+	6	550	c.311G>A	c.(310-312)AGA>AAA	p.R104K	RHOT1_uc002hgw.2_Missense_Mutation_p.R104K|RHOT1_uc002hgy.2_Missense_Mutation_p.R104K|RHOT1_uc002hha.2_5'UTR|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_5'UTR|RHOT1_uc010wby.1_Missense_Mutation_p.R104K|RHOT1_uc002hhb.2_Missense_Mutation_p.R83K|RHOT1_uc002hgv.2_Missense_Mutation_p.R104K	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	104	Miro 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				ATAAATGAAAGAACAGACAAA	0.254													0	0	0	0.009096	0	3	26										A	30503214	G	A	30503214	3	1	54	1	0	0	0	0	1	0	0	0	13343	942	33	1	333	1	RHOT1	17	30503214	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	654214	30503214	50691996	835	15613										
ZNF830	91603	broad.mit.edu	37	chr17	33288630	33288630	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actccggcagggaagcgagtGataaatcaggaagaattgcg	14	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:33288630G>C	uc002hih.3	+	1	82	c.45G>C	c.(43-45)GTG>GTC	p.V15V	CCT6B_uc002hig.2_5'Flank|CCT6B_uc010ctg.2_5'Flank|CCT6B_uc010wcc.1_5'Flank	NM_052857	NP_443089	Q96NB3	ZN830_HUMAN	coiled-coil domain containing 16	15					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)	1		Ovarian(249;0.17)				GGAAGCGAGTGATAAATCAGG	0.557													0	0	0	0.00278	0	21	132										C	33288630	G	C	33288630	2	2	54	1	0	0	0	0	0	0	0	1	18181	1277	45	1		1	ZNF830	17	33288630	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2785416	33288630	47906580	836	15614										
SLFN5	162394	broad.mit.edu	37	chr17	33586238	33586238	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtcagctgctgctttatttGatagaaagcggcttcagtat	10	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:33586238G>C	uc002hjf.3	+	2	646	c.529G>C	c.(529-531)GAT>CAT	p.D177H	SLFN5_uc002hje.2_Missense_Mutation_p.D177H|SLFN5_uc010wcg.1_Missense_Mutation_p.D177H	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	177					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TGCTTTATTTGATAGAAAGCG	0.398													0	0	0	0.008291	0	8	74										C	33586238	G	C	33586238	3	2	54	1	0	0	0	0	1	0	0	0	14737	1290	45	1	531	1	SLFN5	17	33586238	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	297608	33586238	47608972	837	15615										
ACACA	31	broad.mit.edu	37	chr17	35615184	35615184	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaataacatggccccttgGacaaggaacgtgtgcagaat	11	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:35615184G>A	uc002hnm.2	-	13	1692	c.1501C>T	c.(1501-1503)CCA>TCA	p.P501S	ACACA_uc002hnk.2_Missense_Mutation_p.P423S|ACACA_uc002hnl.2_Missense_Mutation_p.P443S|ACACA_uc002hnn.2_Missense_Mutation_p.P501S|ACACA_uc002hno.2_Missense_Mutation_p.P538S|ACACA_uc010cuz.2_Missense_Mutation_p.P501S	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	501	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGGCCCCTTGGACAAGGAACG	0.408													0	0	0	0.006214	0	7	55										A	35615184	G	A	35615184	3	1	54	1	0	0	0	0	1	0	0	0	106	1174	41	1	5715	1	ACACA	17	35615184	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2028946	35615184	45580026	838	15616										
ACACA	31	broad.mit.edu	37	chr17	35627678	35627678	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggaagtcatctgcattgttGacttttctaattcccttccc	7	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:35627678G>A	uc002hnm.2	-	10	1163	c.972C>T	c.(970-972)GTC>GTT	p.V324V	ACACA_uc002hnk.2_Silent_p.V246V|ACACA_uc002hnl.2_Silent_p.V266V|ACACA_uc002hnn.2_Silent_p.V324V|ACACA_uc002hno.2_Silent_p.V361V|ACACA_uc010cuz.2_Silent_p.V324V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	324	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTGCATTGTTGACTTTTCTAA	0.363													0	0	0	0.007413	0	15	151										A	35627678	G	A	35627678	2	1	54	1	0	0	0	0	0	0	0	1	106	1277	45	1		1	ACACA	17	35627678	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	12494	35627678	45567532	839	15617										
STARD3	10948	broad.mit.edu	37	chr17	37810000	37810000	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgctctggatcatcgaactGaatgtgagtgggggcgaggt	16	7	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:37810000G>C	uc002hsd.2	+	2	340	c.216G>C	c.(214-216)CTG>CTC	p.L72L	STARD3_uc010weg.1_Silent_p.L72L|STARD3_uc010weh.1_RNA|STARD3_uc002hse.2_Silent_p.L72L|STARD3_uc010wei.1_Silent_p.L72L|STARD3_uc002hsf.2_5'UTR	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	72	Helical; (Potential).|MENTAL.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCATCGAACTGAATGTGAGTG	0.622											OREG0024381	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	107										C	37810000	G	C	37810000	2	2	54	1	0	0	0	0	0	0	0	1	15256	1277	45	1		1	STARD3	17	37810000	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2182322	37810000	43385210	840	15618										
ERBB2	2064	broad.mit.edu	37	chr17	37884048	37884048	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggaaaggcccaagactctCtccccagggaagaatggggt	13	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:37884048C>G	uc002hso.2	+	27	3757	c.3519C>G	c.(3517-3519)CTC>CTG	p.L1173L	ERBB2_uc002hsm.2_Silent_p.L1143L|ERBB2_uc010cwa.2_Silent_p.L1158L|ERBB2_uc002hsp.2_Silent_p.L976L|ERBB2_uc010cwb.2_3'UTR|ERBB2_uc010wek.1_Silent_p.L897L	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1173	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CCAAGACTCTCTCCCCAGGGA	0.642		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.008291	0	8	61										G	37884048	C	G	37884048	2	3	54	1	0	0	0	0	0	0	0	1	5206	900	32	1		1	ERBB2	17	37884048	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	74048	37884048	43311162	841	15619										
ERBB2	2064	broad.mit.edu	37	chr17	37884180	37884180	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgccttcagcccagccttCgacaacctctattactggga	7	16	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:37884180C>T	uc002hso.2	+	27	3889	c.3651C>T	c.(3649-3651)TTC>TTT	p.F1217F	ERBB2_uc002hsm.2_Silent_p.F1187F|ERBB2_uc010cwa.2_Silent_p.F1202F|ERBB2_uc002hsp.2_Silent_p.F1020F|ERBB2_uc010cwb.2_3'UTR|ERBB2_uc010wek.1_Silent_p.F941F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	1217	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GCCCAGCCTTCGACAACCTCT	0.627		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.00632	0	25	153										T	37884180	C	T	37884180	2	4	54	1	0	0	0	0	0	0	0	1	5206	883	31	1		1	ERBB2	17	37884180	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	132	37884180	43311030	842	15620										
IKZF3	22806	broad.mit.edu	37	chr17	37947692	37947692	+	Missense_Mutation	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aatgtgtcctaagatgccccGtgagcgcatctcttctttgg							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:37947692G>A	uc002hsu.2	-	5	631	c.569C>T	c.(568-570)ACG>ATG	p.T190M	IKZF3_uc002htd.2_Missense_Mutation_p.T156M|IKZF3_uc010cwd.2_Intron|IKZF3_uc002hsv.2_Missense_Mutation_p.T156M|IKZF3_uc010cwe.2_Intron|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Missense_Mutation_p.T190M|IKZF3_uc002hsx.2_Intron|IKZF3_uc002hsy.2_Missense_Mutation_p.T190M|IKZF3_uc002hsz.2_Intron|IKZF3_uc002hta.2_Missense_Mutation_p.T190M|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Missense_Mutation_p.T103M|IKZF3_uc002htc.2_Intron	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	190	C2H2-type 3.				B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			AAGATGCCCCGTGAGCGCATC	0.463													0	0	0	0.006122	0	8	141										A	37947692	G	A	37947692	3	1	54	1	0	0	0	0	1	0	0	0	7616	1145	40	2	976	2	IKZF3	17	37947692	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	63512	37947692	43247518	843	15621	77	2								
IKZF3	22806	broad.mit.edu	37	chr17	37947694	37947694	+	Silent	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtgtcctaagatgccccgtGagcgcatctcttctttggca							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:37947694G>A	uc002hsu.2	-	5	629	c.567C>T	c.(565-567)CTC>CTT	p.L189L	IKZF3_uc002htd.2_Silent_p.L155L|IKZF3_uc010cwd.2_Intron|IKZF3_uc002hsv.2_Silent_p.L155L|IKZF3_uc010cwe.2_Intron|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Silent_p.L189L|IKZF3_uc002hsx.2_Intron|IKZF3_uc002hsy.2_Silent_p.L189L|IKZF3_uc002hsz.2_Intron|IKZF3_uc002hta.2_Silent_p.L189L|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Silent_p.L102L|IKZF3_uc002htc.2_Intron	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	189	C2H2-type 3.				B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATGCCCCGTGAGCGCATCTC	0.468													0	0	0	0.008871	0	10	146										A	37947694	G	A	37947694	2	1	54	1	0	0	0	0	0	0	0	1	7616	1277	45	1		1	IKZF3	17	37947694	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2	37947694	43247516	844	15622	77	2								
CASC3	22794	broad.mit.edu	37	chr17	38318321	38318321	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcatttggatgatgatgaaGatcggaagaatccagcatac	11	6	0	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:38318321G>A	uc010cwt.1	+	5	818	c.523G>A	c.(523-525)GAT>AAT	p.D175N	CASC3_uc010cws.1_Missense_Mutation_p.D175N|CASC3_uc002hue.2_Missense_Mutation_p.D175N	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	175	Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles.|Sufficient to form the EJC.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						TGATGATGAAGATCGGAAGAA	0.478													0	0	0	0.00245	0	13	82										A	38318321	G	A	38318321	3	1	54	1	0	0	0	0	1	0	0	0	2661	942	33	1	541	1	CASC3	17	38318321	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	370627	38318321	42876889	845	15623										
KRT26	353288	broad.mit.edu	37	chr17	38928361	38928361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atccaccagaaagtcgaaaaGacatggtggcagcacagccg	11	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:38928361G>C	uc002hvf.2	-	1	51	c.5C>G	c.(4-6)TCT>TGT	p.S2C		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	2	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				AAGTCGAAAAGACATGGTGGC	0.547													0	0	0	0.003163	0	15	92										C	38928361	G	C	38928361	3	2	54	1	0	0	0	0	1	0	0	0	8463	942	33	1	1433	1	KRT26	17	38928361	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	610040	38928361	42266849	846	15624										
KRT15	3866	broad.mit.edu	37	chr17	39671773	39671773	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtaagtagcgatctcctgctCcagccgtgtctttatgtcaa	9	11	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:39671773C>T	uc002hwy.2	-	6	1389	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	KRT15_uc002hwz.2_Missense_Mutation_p.E302K|KRT15_uc002hxa.2_Missense_Mutation_p.E235K|KRT15_uc002hxb.1_Missense_Mutation_p.E235K	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	400	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				ATCTCCTGCTCCAGCCGTGTC	0.602													0	0	0	0.008871	0	15	158										T	39671773	C	T	39671773	3	4	54	1	0	0	0	0	1	0	0	0	8452	864	30	1	184	1	KRT15	17	39671773	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	743412	39671773	41523437	847	15625										
DNAJC7	7266	broad.mit.edu	37	chr17	40169363	40169363	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgctacccggttacctcttCgcctcttggtcgtcgagcag	10	15	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:40169363C>T	uc002hyo.2	-	1	309	c.72G>A	c.(70-72)GCG>GCA	p.A24A	DNAJC7_uc010wgb.1_5'Flank|DNAJC7_uc010wgc.1_5'UTR|DNAJC7_uc002hyp.2_5'UTR|DNAJC7_uc010cxw.2_5'Flank|NKIRAS2_uc002hyq.2_5'Flank|NKIRAS2_uc010wgd.1_5'Flank|NKIRAS2_uc002hyr.2_5'Flank|NKIRAS2_uc002hys.2_5'Flank|NKIRAS2_uc010wge.1_5'Flank|NKIRAS2_uc002hyt.2_5'Flank	NM_003315	NP_003306	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	24					chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding			ovary(1)	1		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				GTTACCTCTTCGCCTCTTGGT	0.652													0	0	0	0.00361	0	38	261										T	40169363	C	T	40169363	2	4	54	1	0	0	0	0	0	0	0	1	4654	871	31	1		1	DNAJC7	17	40169363	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	497590	40169363	41025847	848	15626										
NBR1	4077	broad.mit.edu	37	chr17	41352511	41352511	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggctggggaaagactccctgGaggggagaaccagccacagg	17	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:41352511G>T	uc010czd.2	+	17	2494	c.2354G>T	c.(2353-2355)GGA>GTA	p.G785V	NBR1_uc010diz.2_Missense_Mutation_p.G785V|NBR1_uc010whu.1_Missense_Mutation_p.G785V|NBR1_uc010whv.1_Missense_Mutation_p.G785V|NBR1_uc010whw.1_Missense_Mutation_p.G764V	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	785					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		AGACTCCCTGGAGGGGAGAAC	0.602													1	0	1.61879e-10	0.001368	1.71401e-10	12	35										T	41352511	G	T	41352511	3	4	54	1	0	0	0	0	1	0	0	0	10200	1174	41	3	2416	3	NBR1	17	41352511	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1183148	41352511	39842699	849	15627										
MPP3	4356	broad.mit.edu	37	chr17	41879098	41879098	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccaactaacaggtacccagtGagtgtccttgctcagcttct	8	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:41879098G>A	uc002iei.3	-	20	1895	c.1729C>T	c.(1729-1731)CAC>TAC	p.H577Y	MPP3_uc002ieh.2_Missense_Mutation_p.H602Y|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	577					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GGTACCCAGTGAGTGTCCTTG	0.363													0	0	0	0.00278	0	20	162										A	41879098	G	A	41879098	3	1	54	1	0	0	0	0	1	0	0	0	9735	1290	45	1	32	1	MPP3	17	41879098	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	526587	41879098	39316112	850	15628										
ADAM11	4185	broad.mit.edu	37	chr17	42850646	42850646	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagatatacaaggagcagctCaacactcgcatcgtcctggt	9	12	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:42850646C>G	uc002ihh.2	+	11	843	c.843C>G	c.(841-843)CTC>CTG	p.L281L	ADAM11_uc010wjd.1_Silent_p.L81L	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	281	Extracellular (Potential).|Peptidase M12B.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				AGGAGCAGCTCAACACTCGCA	0.607													0	0	0	0.007291	0	23	173										G	42850646	C	G	42850646	2	3	54	1	0	0	0	0	0	0	0	1	235	813	29	1		1	ADAM11	17	42850646	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	971548	42850646	38344564	851	15629										
KPNB1	3837	broad.mit.edu	37	chr17	45747074	45747074	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccctaatagaattaatgaaaGaccccagtgtagttgttcga	8	8	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:45747074G>C	uc002ilt.1	+	11	1591	c.1255G>C	c.(1255-1257)GAC>CAC	p.D419H	KPNB1_uc010wkw.1_Missense_Mutation_p.D274H|KPNB1_uc010wkx.1_Missense_Mutation_p.D203H	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	419	HEAT 6.|Ran-GTP binding.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						ATTAATGAAAGACCCCAGTGT	0.408													0	0	0	0.012319	0	15	114										C	45747074	G	C	45747074	3	2	54	1	0	0	0	0	1	0	0	0	8435	942	33	1	1297	1	KPNB1	17	45747074	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2896428	45747074	35448136	852	15630										
LRRC46	90506	broad.mit.edu	37	chr17	45909489	45909489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtcagcccagggtccagagGaagggggcgtctgcatcact	15	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:45909489G>A	uc002ima.2	+	2	290	c.34G>A	c.(34-36)GAA>AAA	p.E12K	MRPL10_uc010wky.1_5'Flank|MRPL10_uc002ilz.2_5'Flank|MRPL10_uc002ily.2_5'Flank|LRRC46_uc002imb.2_5'UTR	NM_033413	NP_219481	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	12										ovary(1)	1						GGGTCCAGAGGAAGGGGGCGT	0.532													0	0	0	0.008871	0	16	155										A	45909489	G	A	45909489	3	1	54	1	0	0	0	0	1	0	0	0	9003	1175	41	1	40	1	LRRC46	17	45909489	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	162415	45909489	35285721	853	15631										
SCRN2	90507	broad.mit.edu	37	chr17	45916235	45916235	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgcacaggctgctgggtcaGggagaagatctgagcaaagt	16	8	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:45916235G>C	uc002imd.2	-	5	820	c.694C>G	c.(694-696)CTG>GTG	p.L232V	SCRN2_uc002imc.2_Missense_Mutation_p.L240V|SCRN2_uc002imf.2_Missense_Mutation_p.L232V|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	232					proteolysis		dipeptidase activity			ovary(1)	1						TGCTGGGTCAGGGAGAAGATC	0.662													0	0	0	0.007291	0	27	202										C	45916235	G	C	45916235	3	2	54	1	0	0	0	0	1	0	0	0	13939	991	35	4	617	4	SCRN2	17	45916235	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6746	45916235	35278975	854	15632										
IGF2BP1	10642	broad.mit.edu	37	chr17	47109291	47109291	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgaacaccgagagtgagacGgcagtggtgaatgtcaccta	14	8	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:47109291G>A	uc002iom.2	+	5	691	c.357G>A	c.(355-357)ACG>ACA	p.T119T	IGF2BP1_uc010dbj.2_Silent_p.T119T	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	119	RRM 2.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						AGAGTGAGACGGCAGTGGTGA	0.577											OREG0024529	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	53	348										A	47109291	G	A	47109291	2	1	54	1	0	0	0	0	0	0	0	1	7573	1103	39	2		2	IGF2BP1	17	47109291	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1193056	47109291	34085919	855	15633										
MYST2	11143	broad.mit.edu	37	chr17	47886483	47886483	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgttgttgatggttgcaggtGagagcacagagccgggataa	16	6	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:47886483G>A	uc002ipm.2	+	6	792	c.666G>A	c.(664-666)GTG>GTA	p.V222V	MYST2_uc002ipl.1_Intron|MYST2_uc010wma.1_Silent_p.V83V|MYST2_uc010wmb.1_Intron|MYST2_uc010wmc.1_Intron|MYST2_uc010wmd.1_Silent_p.V66V|MYST2_uc010wme.1_Intron	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	222					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GGTTGCAGGTGAGAGCACAGA	0.393													0	0	0	0.00308	0	7	56										A	47886483	G	A	47886483	2	1	54	1	0	0	0	0	0	0	0	1	10103	1277	45	1		1	MYST2	17	47886483	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	777192	47886483	33308727	856	15634										
ITGA3	3675	broad.mit.edu	37	chr17	48155409	48155409	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctccctgacccttgtggcaGatggagctgctcatcgcctt	10	15	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:48155409G>A	uc010dbl.2	+	17	2604	c.2140_splice	c.e17-1	p.M714_splice	ITGA3_uc010dbm.2_Splice_Site_p.M714_splice	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor						blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						CCTTGTGGCAGATGGAGCTGC	0.592													0	0	0	0.004007	0	13	158										A	48155409	G	A	48155409	5	1	54	1	0	0	0	0	0	0	1	0	7877	956	33	1	2205	1	ITGA3	17	48155409	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	268926	48155409	33039801	857	15635										
PPP1R9B	84687	broad.mit.edu	37	chr17	48218657	48218657	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	actcggcccttggtgttccgGagcacagacgccgcgaagct	13	14	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:48218657G>C	uc002iqh.3	-	6	1710	c.1707C>G	c.(1705-1707)CTC>CTG	p.L569L		NM_032595	NP_115984	Q96SB3	NEB2_HUMAN	protein phosphatase 1, regulatory subunit 9B	567	PDZ.				cell cycle arrest|cell differentiation|cell migration|filopodium assembly|negative regulation of cell growth|nervous system development|regulation of cell growth by extracellular stimulus|regulation of cell proliferation|regulation of exit from mitosis|RNA splicing	adherens junction|cytoskeleton|dendritic spine|filopodium|lamellipodium|nucleoplasm|protein phosphatase type 1 complex|ruffle membrane|synapse	actin binding|protein phosphatase 1 binding|protein phosphatase inhibitor activity				0						TGGTGTTCCGGAGCACAGACG	0.627													0	0	0	0.009096	0	3	16										C	48218657	G	C	48218657	2	2	54	1	0	0	0	0	0	0	0	1	12379	1161	41	1		1	PPP1R9B	17	48218657	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	63248	48218657	32976553	858	15636										
TOM1L1	10040	broad.mit.edu	37	chr17	53014503	53014503	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttctgccccatctcaagatCtcctcgacctaagtcccagt	5	17	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:53014503C>A	uc002iud.2	+	10	1124	c.949C>A	c.(949-951)CTC>ATC	p.L317I	TOM1L1_uc002iuc.2_Missense_Mutation_p.L317I|TOM1L1_uc010dca.1_Missense_Mutation_p.L317I|TOM1L1_uc010wnb.1_Missense_Mutation_p.L310I|TOM1L1_uc010wnc.1_Missense_Mutation_p.L240I|TOM1L1_uc010dbz.2_Missense_Mutation_p.L240I|TOM1L1_uc010wnd.1_Missense_Mutation_p.L205I|TOM1L1_uc010dcb.1_RNA	NM_005486	NP_005477	O75674	TM1L1_HUMAN	target of myb1-like 1	317					intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1						ATCTCAAGATCTCCTCGACCT	0.433													1	0	5.16669e-11	0.010729	5.47956e-11	10	81										A	53014503	C	A	53014503	3	1	54	1	0	0	0	0	1	0	0	0	16349	913	32	3	987	3	TOM1L1	17	53014503	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4795846	53014503	28180707	859	15637										
SFRS1	6426	broad.mit.edu	37	chr17	56082931	56082931	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acttggacttctgggcccatCaactttaacccggatgtagg	10	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:56082931C>G	uc002ivi.2	-	4	792	c.583G>C	c.(583-585)GAT>CAT	p.D195H	SFRS1_uc002ivj.2_3'UTR	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	195	RRM 2.			Missing: In MR-E; loss of ability to activate splicing.|Missing: In MR-D; loss of ability to activate splicing.|Missing: In MR-A; loss of ability to activate splicing.|Missing: In MR-B; strongly inhibits splicing.	mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		CTGGGCCCATCAACTTTAACC	0.463													0	0	0	0.006214	0	7	83										G	56082931	C	G	56082931	3	3	54	1	0	0	0	0	1	0	0	0	14165	826	29	1	167	1	SFRS1	17	56082931	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3068428	56082931	25112279	860	15638										
SEPT4	5414	broad.mit.edu	37	chr17	56606496	56606496	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccagcttcagtcctgtcctCagggacagaattcccttgcc	8	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:56606496C>T	uc002iwm.1	-	1	168	c.40G>A	c.(40-42)GAG>AAG	p.E14K	SEPT4_uc002iwk.1_5'Flank|SEPT4_uc010wnw.1_5'Flank|SEPT4_uc002iwl.1_5'Flank|SEPT4_uc002iwn.1_Missense_Mutation_p.E14K|SEPT4_uc002iwo.1_Intron|SEPT4_uc002iwp.1_Intron|SEPT4_uc010wnx.1_Intron|SEPT4_uc010wny.1_Intron|SEPT4_uc010dcy.1_Intron	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	14					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTCCTGTCCTCAGGGACAGAA	0.552													0	0	0	0.004878	0	24	132										T	56606496	C	T	56606496	3	4	54	1	0	0	0	0	1	0	0	0	14066	835	29	1	1529	1	SEPT4	17	56606496	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	523565	56606496	24588714	861	15639										
RNFT1	51136	broad.mit.edu	37	chr17	58040624	58040624	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttttctctgacccagatgtCtttgcttcaggcctctgtct	7	12	5	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:58040624C>G	uc002iya.2	-	2	171	c.78G>C	c.(76-78)AAG>AAC	p.K26N	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.K26N|RNFT1_uc002iyd.3_Missense_Mutation_p.K26N	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	26						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			ACCCAGATGTCTTTGCTTCAG	0.433													0	0	0	0.001368	0	11	75										G	58040624	C	G	58040624	3	3	54	1	0	0	0	0	1	0	0	0	13501	912	32	1	1261	1	RNFT1	17	58040624	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1434128	58040624	23154586	862	15640										
MARCH10	162333	broad.mit.edu	37	chr17	60814201	60814201	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggctcacttcttcttgaaGaatgacctctgcaattttca	7	10	5	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:60814201G>C	uc010ddr.2	-	6	1266	c.1028C>G	c.(1027-1029)TCT>TGT	p.S343C	MARCH10_uc002jag.3_Missense_Mutation_p.S343C|MARCH10_uc010dds.2_Missense_Mutation_p.S381C|MARCH10_uc002jah.2_Missense_Mutation_p.S342C|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	343							ligase activity|zinc ion binding				0						TCTTCTTGAAGAATGACCTCT	0.458													0	0	0	0.00499	0	16	71										C	60814201	G	C	60814201	3	2	54	1	0	0	0	0	1	0	0	0	9299	942	33	1	1422	1	MARCH10	17	60814201	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2773577	60814201	20381009	863	15641										
ACE	1636	broad.mit.edu	37	chr17	61566065	61566065	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagacctgttatgggcatggGagggctggcgagacaaggcg	18	7	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:61566065G>A	uc002jau.1	+	16	2384	c.2362G>A	c.(2362-2364)GAG>AAG	p.E788K	ACE_uc002jav.1_Missense_Mutation_p.E214K|ACE_uc010ddv.1_Missense_Mutation_p.E15K|ACE_uc010wpj.1_Missense_Mutation_p.E214K|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.E98K	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	788	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	ATGGGCATGGGAGGGCTGGCG	0.562													0	0	0	0.006122	0	16	146										A	61566065	G	A	61566065	3	1	54	1	0	0	0	0	1	0	0	0	136	1175	41	1	2627	1	ACE	17	61566065	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	751864	61566065	19629145	864	15642										
MAP3K3	4215	broad.mit.edu	37	chr17	61767079	61767079	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccctctctgtgcaggagagGaatgtgccaaccaagtgtga	13	10	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:61767079G>A	uc002jbg.2	+	11	1366	c.1047G>A	c.(1045-1047)AGG>AGA	p.R349R	MAP3K3_uc002jbe.2_Silent_p.R380R|MAP3K3_uc002jbf.2_Silent_p.R380R|MAP3K3_uc002jbh.2_Silent_p.R376R|MAP3K3_uc010wpo.1_Silent_p.R264R|MAP3K3_uc010wpp.1_Silent_p.R345R	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	349					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						TGCAGGAGAGGAATGTGCCAA	0.627													0	0	0	0.000602	0	3	50										A	61767079	G	A	61767079	2	1	54	1	0	0	0	0	0	0	0	1	9251	1165	41	1		1	MAP3K3	17	61767079	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	201014	61767079	19428131	865	15643										
CACNG5	27091	broad.mit.edu	37	chr17	64880760	64880760	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcgtttgccttcgccgccatCtccttccttttaacggaggt	8	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:64880760C>T	uc010wqi.1	+	5	789	c.552C>T	c.(550-552)ATC>ATT	p.I184I	CACNG5_uc002jfr.2_Silent_p.I184I|CACNG5_uc010wqj.1_Silent_p.I184I	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	184	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TCGCCGCCATCTCCTTCCTTT	0.552													0	0	0	0.002299	0	19	108										T	64880760	C	T	64880760	2	4	54	1	0	0	0	0	0	0	0	1	2560	903	32	1		1	CACNG5	17	64880760	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3113681	64880760	16314450	866	15644										
BPTF	2186	broad.mit.edu	37	chr17	65925584	65925584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caatacctcaggctctggagGaaccacaagcaattcacaag	8	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:65925584G>A	uc002jgf.2	+	17	6192	c.6131G>A	c.(6130-6132)GGA>GAA	p.G2044E	BPTF_uc002jge.2_Missense_Mutation_p.G2170E	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2170					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GGCTCTGGAGGAACCACAAGC	0.398													0	0	0	0.00308	0	8	37										A	65925584	G	A	65925584	3	1	54	1	0	0	0	0	1	0	0	0	1495	1174	41	1	6583	1	BPTF	17	65925584	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1044824	65925584	15269626	867	15645										
SDK2	54549	broad.mit.edu	37	chr17	71348646	71348646	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaggggctgctgggggtgccGaaaccatagtcgttgaccgc	17	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:71348646G>A	uc010dfm.2	-	41	5724	c.5724C>T	c.(5722-5724)TTC>TTT	p.F1908F	SDK2_uc002jjt.3_Silent_p.F1048F	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1908	Fibronectin type-III 13.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TGGGGGTGCCGAAACCATAGT	0.647													0	0	0	0.000602	0	3	42										A	71348646	G	A	71348646	2	1	54	1	0	0	0	0	0	0	0	1	13969	1049	37	1		1	SDK2	17	71348646	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5423062	71348646	9846564	868	15646										
KIF19	124602	broad.mit.edu	37	chr17	72348427	72348427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgcgggagctggaggaggGcagcctggagcaggccacca	18	12	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:72348427G>A	uc002jkm.3	+	14	2066	c.1928G>A	c.(1927-1929)GGC>GAC	p.G643D	KIF19_uc002jkl.2_Missense_Mutation_p.G601D	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	643					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						CTGGAGGAGGGCAGCCTGGAG	0.672													0	0	0	0.009096	0	4	44										A	72348427	G	A	72348427	3	1	54	1	0	0	0	0	1	0	0	0	8282	1203	42	2	1982	2	KIF19	17	72348427	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	999781	72348427	8846783	869	15647										
GRIN2C	2905	broad.mit.edu	37	chr17	72846450	72846450	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accactctggccagcttcttGaggatgtcgatgcagaatcc	10	12	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:72846450G>C	uc002jlt.1	-	6	1542	c.1386C>G	c.(1384-1386)CTC>CTG	p.L462L	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.L462L	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	462	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	CCAGCTTCTTGAGGATGTCGA	0.592													0	0	0	0.003755	0	30	305										C	72846450	G	C	72846450	2	2	54	1	0	0	0	0	0	0	0	1	6781	1277	45	1		1	GRIN2C	17	72846450	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	498023	72846450	8348760	870	15648										
FDXR	2232	broad.mit.edu	37	chr17	72859310	72859310	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccggtgaggaagctgtcagtCatggttgtggctatgacacc	14	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:72859310C>T	uc002jly.2	-	11	1320	c.1233G>A	c.(1231-1233)ATG>ATA	p.M411I	GRIN2C_uc002jlu.1_5'Flank|GRIN2C_uc002jlv.1_5'Flank|FDXR_uc010wri.1_Missense_Mutation_p.M359I|FDXR_uc010wrj.1_Missense_Mutation_p.M409I|FDXR_uc002jlw.2_Missense_Mutation_p.M168I|FDXR_uc002jlx.2_Missense_Mutation_p.M417I|FDXR_uc002jmc.2_Missense_Mutation_p.M383I|FDXR_uc010wrk.1_Missense_Mutation_p.M442I|FDXR_uc010wrl.1_Missense_Mutation_p.M454I|FDXR_uc002jma.2_Missense_Mutation_p.M412I|FDXR_uc010wrm.1_Missense_Mutation_p.M371I|FDXR_uc002jlz.2_Missense_Mutation_p.M403I|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	411					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					AGCTGTCAGTCATGGTTGTGG	0.632													0	0	0	0.001984	0	5	54										T	72859310	C	T	72859310	3	4	54	1	0	0	0	0	1	0	0	0	5807	826	29	1	250	1	FDXR	17	72859310	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	12860	72859310	8335900	871	15649										
SUMO2	6613	broad.mit.edu	37	chr17	73164461	73164461	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acacctcccgtctgctgttgGaacacatcaattgtatcttc	6	13	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:73164461G>C	uc002jne.2	-	4	430	c.261C>G	c.(259-261)TTC>TTG	p.F87L	SUMO2_uc002jnf.2_Missense_Mutation_p.F63L	NM_006937	NP_008868	P61956	SUMO2_HUMAN	SMT3 suppressor of mif two 3 homolog 2 isoform a	87	Ubiquitin-like.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation	nucleus	ubiquitin protein ligase binding				0	all_lung(278;0.14)|Lung NSC(278;0.168)					TCTGCTGTTGGAACACATCAA	0.353													0	0	0	0.009096	0	2	11										C	73164461	G	C	73164461	3	2	54	1	0	0	0	0	1	0	0	0	15385	1165	41	1	30	1	SUMO2	17	73164461	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	305151	73164461	8030749	872	15650										
SAP30BP	29115	broad.mit.edu	37	chr17	73663485	73663485	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagaatgttctgtcgtctctCgcagtttacgcggaagattc	10	9	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:73663485C>G	uc002jpe.2	+	1	87	c.33C>G	c.(31-33)CTC>CTG	p.L11L	RECQL5_uc010dgk.2_5'Flank|RECQL5_uc010dgl.2_5'Flank|RECQL5_uc002jpb.1_5'Flank|RECQL5_uc002joz.3_5'Flank|RECQL5_uc002jpa.3_5'Flank|SAP30BP_uc010dgm.1_Silent_p.L11L|SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Silent_p.L11L	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	11					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGTCGTCTCTCGCAGTTTACG	0.607													0	0	0	0.006122	0	12	73										G	73663485	C	G	73663485	2	3	54	1	0	0	0	0	0	0	0	1	13834	871	31	1		1	SAP30BP	17	73663485	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	499024	73663485	7531725	873	15651										
ITGB4	3691	broad.mit.edu	37	chr17	73753570	73753570	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgtgacccaggagtttgtGagccggacactgaccaccag	12	12	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:73753570G>C	uc002jpg.2	+	40	5590	c.5403G>C	c.(5401-5403)GTG>GTC	p.V1801V	ITGB4_uc002jph.2_Silent_p.V1731V|ITGB4_uc002jpi.3_Silent_p.V1731V|ITGB4_uc002jpj.2_Silent_p.V1784V|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1801	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGAGTTTGTGAGCCGGACAC	0.637													0	0	0	0.00632	0	24	143										C	73753570	G	C	73753570	2	2	54	1	0	0	0	0	0	0	0	1	7897	1277	45	1		1	ITGB4	17	73753570	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	90085	73753570	7441640	874	15652										
TRIM47	91107	broad.mit.edu	37	chr17	73872363	73872363	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgcaggaagctgactgagtCagcttcagggacctggctga	14	10	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:73872363C>T	uc002jpw.2	-	3	1009	c.982G>A	c.(982-984)GAC>AAC	p.D328N	TRIM47_uc002jpv.2_Missense_Mutation_p.D90N	NM_033452	NP_258411	Q96LD4	TRI47_HUMAN	tripartite motif-containing 47	328						cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGACTGAGTCAGCTTCAGGG	0.662													0	0	0	0.001855	0	10	26										T	73872363	C	T	73872363	3	4	54	1	0	0	0	0	1	0	0	0	16519	826	29	1	950	1	TRIM47	17	73872363	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	118793	73872363	7322847	875	15653										
EVPL	2125	broad.mit.edu	37	chr17	74005809	74005809	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcttggtcctctcctcctcGaggaggctcctcagcctgga	10	15	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:74005809G>A	uc002jqi.2	-	22	3705	c.3477C>T	c.(3475-3477)CTC>CTT	p.L1159L	EVPL_uc010wss.1_Silent_p.L1181L|EVPL_uc010wst.1_Silent_p.L629L	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1159	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TCTCCTCCTCGAGGAGGCTCC	0.627													0	0	0	0.009096	0	4	63										A	74005809	G	A	74005809	2	1	54	1	0	0	0	0	0	0	0	1	5292	1045	37	1		1	EVPL	17	74005809	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	133446	74005809	7189401	876	15654										
TNRC6C	57690	broad.mit.edu	37	chr17	76047219	76047219	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaacagacaggaacagggtgGatcggggggccggtaccggt	18	8	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:76047219G>A	uc002jud.2	+	4	2676	c.2076G>A	c.(2074-2076)TGG>TGA	p.W692*	TNRC6C_uc002juf.2_Nonsense_Mutation_p.W692*|TNRC6C_uc002jue.2_Nonsense_Mutation_p.W692*	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	692	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GAACAGGGTGGATCGGGGGGC	0.542													0	0	0	0.00308	0	7	19										A	76047219	G	A	76047219	4	1	54	1	0	0	0	0	0	1	0	0	16339	1183	41	1	2078	1	TNRC6C	17	76047219	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2041410	76047219	5147991	877	15655										
TNRC6C	57690	broad.mit.edu	37	chr17	76089176	76089176	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctgacagtgataaaatctCaaatggctctagcatcaact	6	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:76089176C>T	uc002jud.2	+	16	4733	c.4133C>T	c.(4132-4134)TCA>TTA	p.S1378L	TNRC6C_uc002juf.2_Missense_Mutation_p.S1375L	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1378	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			GATAAAATCTCAAATGGCTCT	0.512													0	0	0	0.001984	0	5	49										T	76089176	C	T	76089176	3	4	54	1	0	0	0	0	1	0	0	0	16339	838	29	1	4183	1	TNRC6C	17	76089176	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	41957	76089176	5106034	878	15656										
TMC6	11322	broad.mit.edu	37	chr17	76113906	76113906	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagacggcgtagcagaggaaGacagcggcgcccaggaaggc	17	11	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:76113906G>C	uc002juj.1	-	15	2124	c.1998C>G	c.(1996-1998)GTC>GTG	p.V666V	TMC6_uc002jui.1_Silent_p.V245V|TMC6_uc010dhf.1_Silent_p.V499V|TMC6_uc002juk.2_Silent_p.V666V|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Silent_p.V666V	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	666	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCAGAGGAAGACAGCGGCGC	0.687									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.00308	0	5	27										C	76113906	G	C	76113906	2	2	54	1	0	0	0	0	0	0	0	1	15986	929	33	1		1	TMC6	17	76113906	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	24730	76113906	5081304	879	15657										
DNAH17	8632	broad.mit.edu	37	chr17	76540022	76540022	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcaattcttccatccaagtCtaacagggcctctttcttat	6	12	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:76540022C>T	uc002jvv.1	-	13	1661	c.1555G>A	c.(1555-1557)GAC>AAC	p.D519N						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCATCCAAGTCTAACAGGGCC	0.502													0	0	0	0.00278	0	22	125										T	76540022	C	T	76540022	3	4	54	1	0	0	0	0	1	0	0	0	4601	913	32	1	11199	1	DNAH17	17	76540022	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	426116	76540022	4655188	880	15658										
CHMP6	79643	broad.mit.edu	37	chr17	78971126	78971126	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacgccatcctggaggagctGagcgcaatcactcaggtaac	12	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:78971126G>A	uc002jyw.3	+	6	558	c.480G>A	c.(478-480)CTG>CTA	p.L160L		NM_024591	NP_078867	Q96FZ7	CHMP6_HUMAN	chromatin modifying protein 6	160					cellular membrane organization|endosome transport|protein transport	cytosol|endomembrane system|late endosome membrane	protein N-terminus binding			ovary(1)	1	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0175)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			TGGAGGAGCTGAGCGCAATCA	0.632													0	0	0	0.001168	0	5	32										A	78971126	G	A	78971126	2	1	54	1	0	0	0	0	0	0	0	1	3360	1277	45	1		1	CHMP6	17	78971126	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2431104	78971126	2224084	881	15659										
ACTG1	71	broad.mit.edu	37	chr17	79479015	79479015	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccggggccacgcgcagctCgttgtagaaggtgtggtgcc	16	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:79479015C>A	uc002kaj.1	-	2	302	c.277G>T	c.(277-279)GAG>TAG	p.E93*	ACTG1_uc002kah.1_5'Flank|ACTG1_uc002kai.1_Nonsense_Mutation_p.E50*|ACTG1_uc002kak.1_Nonsense_Mutation_p.E93*|ACTG1_uc010wun.1_Nonsense_Mutation_p.E93*|ACTG1_uc002kal.1_Nonsense_Mutation_p.E93*|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	93					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			ACGCGCAGCTCGTTGTAGAAG	0.617													1	0	1.30897e-18	0.009535	1.41134e-18	25	113										A	79479015	C	A	79479015	4	1	54	1	0	0	0	0	0	1	0	0	196	893	31	3	866	3	ACTG1	17	79479015	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	507889	79479015	1716195	882	15660										
C17orf90	339229	broad.mit.edu	37	chr17	79632293	79632293	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaggccttgaggttctcatCagccacgtgctcctccaggg	12	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:79632293C>G	uc002kba.2	-	2	393	c.382G>C	c.(382-384)GAT>CAT	p.D128H	C17orf90_uc002kbb.2_3'UTR|CCDC137_uc002kbc.3_5'Flank|CCDC137_uc002kbd.2_5'Flank	NM_001039842	NP_001034931	Q5BKU9	CQ090_HUMAN	hypothetical protein LOC339229	128											0	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGGTTCTCATCAGCCACGTGC	0.667													0	0	0	0.004482	0	8	93										G	79632293	C	G	79632293	3	3	54	1	0	0	0	0	1	0	0	0	1891	826	29	1	65	1	C17orf90	17	79632293	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	153278	79632293	1562917	883	15661										
P4HB	5034	broad.mit.edu	37	chr17	79817199	79817199	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctcggaaccttctgccttCagcttcccagcggctttggc	9	15	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:79817199C>T	uc002kbn.1	-	2	407	c.210G>A	c.(208-210)CTG>CTA	p.L70L	P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	70	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CTTCTGCCTTCAGCTTCCCAG	0.602													0	0	0	0.004656	0	23	160										T	79817199	C	T	79817199	2	4	54	1	0	0	0	0	0	0	0	1	11359	813	29	1		1	P4HB	17	79817199	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	184906	79817199	1378011	884	15662										
RAB40B	10966	broad.mit.edu	37	chr17	80616443	80616443	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agctccgtgaacgactctgtGatgttgaaattgcacagagg	12	8	1	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr17:80616443G>A	uc002kft.2	-	5	615	c.489C>T	c.(487-489)ATC>ATT	p.I163I	RAB40B_uc002kfs.2_RNA	NM_006822	NP_006813	Q12829	RB40B_HUMAN	RAB40B, member RAS oncogene family	163					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			central_nervous_system(1)	1	Breast(20;0.00132)|all_neural(118;0.0952)	all_cancers(8;0.072)|all_epithelial(8;0.139)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			ACGACTCTGTGATGTTGAAAT	0.657													0	0	0	0.001984	0	7	183										A	80616443	G	A	80616443	2	1	54	1	0	0	0	0	0	0	0	1	12941	1280	45	1		1	RAB40B	17	80616443	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	799244	80616443	578767	885	15663										
MYOM1	8736	broad.mit.edu	37	chr18	3131437	3131437	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcactaagtccagctgcattGactgctctgacccggaaaat	8	12	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:3131437G>C	uc002klp.2	-	17	2776	c.2442C>G	c.(2440-2442)GTC>GTG	p.V814V	MYOM1_uc002klq.2_Silent_p.V814V	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	814	Fibronectin type-III 3.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CAGCTGCATTGACTGCTCTGA	0.378													0	0	0	0.00308	0	6	25										C	3131437	G	C	3131437	2	2	54	1	0	0	0	0	0	0	0	1	10091	1277	45	1		1	MYOM1	18	3131437	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		3131437	74945811	886	15664										
ARHGAP28	79822	broad.mit.edu	37	chr18	6896547	6896547	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtccatgctccacttctctCcaaggtgtccatggccattc	8	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:6896547C>G	uc010wzi.1	+	15	1659	c.1421C>G	c.(1420-1422)TCC>TGC	p.S474C	ARHGAP28_uc002knc.2_Missense_Mutation_p.S599C|ARHGAP28_uc002knd.2_Missense_Mutation_p.S492C|ARHGAP28_uc002kne.2_Missense_Mutation_p.S492C|ARHGAP28_uc002knf.2_Missense_Mutation_p.S483C			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	474					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				CCACTTCTCTCCAAGGTGTCC	0.443													0	0	0	0.003163	0	13	67										G	6896547	C	G	6896547	3	3	54	1	0	0	0	0	1	0	0	0	877	855	30	1	1529	1	ARHGAP28	18	6896547	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3765110	6896547	71180701	887	15665										
LAMA3	3909	broad.mit.edu	37	chr18	21355773	21355773	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tagcctgcagctgtgaccctGagcatgcggatggctgtgaa	14	10	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:21355773G>A	uc002kuq.2	+	10	1377	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	LAMA3_uc010dlv.1_Missense_Mutation_p.E431K|LAMA3_uc002kur.2_Missense_Mutation_p.E431K	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	431	Laminin EGF-like 3.|Domain V.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTGACCCTGAGCATGCGGA	0.483													0	0	0	0.006214	0	8	25										A	21355773	G	A	21355773	3	1	54	1	0	0	0	0	1	0	0	0	8607	1291	45	1	1329	1	LAMA3	18	21355773	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	14459226	21355773	56721475	888	15666										
SS18	6760	broad.mit.edu	37	chr18	23619259	23619259	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaatggaatcttaccctgttGaggaggtctatagggaggaa	13	5	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:23619259G>T	uc002kvm.2	-	6	847	c.769C>A	c.(769-771)CAA>AAA	p.Q257K	SS18_uc002kvn.2_Missense_Mutation_p.Q257K|SS18_uc010xbf.1_Missense_Mutation_p.Q175K|SS18_uc010xbg.1_Missense_Mutation_p.Q205K|SS18_uc010xbh.1_Missense_Mutation_p.Q205K|SS18_uc010xbi.1_Missense_Mutation_p.Q234K|SS18_uc010dlz.1_Missense_Mutation_p.Q205K	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	257	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TTACCCTGTTGAGGAGGTCTA	0.393			T	SSX1| SSX2	synovial sarcoma								1	0	2.32078e-09	0.003163	2.45329e-09	13	69										T	23619259	G	T	23619259	3	4	54	1	0	0	0	0	1	0	0	0	15174	1299	45	3	511	3	SS18	18	23619259	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2263486	23619259	54457989	889	15667										
C18orf34	374864	broad.mit.edu	37	chr18	30926330	30926330	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taatgagacgaatggcctctGagagcaatgtttccatttcc	9	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:30926330G>T	uc002kxn.2	-	8	645	c.503C>A	c.(502-504)TCA>TAA	p.S168*	C18orf34_uc010xbr.1_Nonsense_Mutation_p.S168*|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Nonsense_Mutation_p.S168*|C18orf34_uc002kxp.2_Nonsense_Mutation_p.S168*	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	168	Potential.									ovary(1)	1						AATGGCCTCTGAGAGCAATGT	0.348													1	0	5.18039e-06	0.00308	5.3926e-06	5	36										T	30926330	G	T	30926330	4	4	54	1	0	0	0	0	0	1	0	0	1902	1294	45	3	2160	3	C18orf34	18	30926330	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	7307071	30926330	47150918	890	15668										
KIAA1632	57724	broad.mit.edu	37	chr18	43467730	43467730	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccttacctgtcccaagatctCaatacatgaagtaaagaact	5	11	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:43467730C>G	uc002lbm.2	-	29	5195	c.5095G>C	c.(5095-5097)GAG>CAG	p.E1699Q	KIAA1632_uc010xcq.1_Missense_Mutation_p.E253Q|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.E574Q	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1699					autophagy						0						CCCAAGATCTCAATACATGAA	0.433													0	0	0	0.007413	0	13	54										G	43467730	C	G	43467730	3	3	54	1	0	0	0	0	1	0	0	0	8249	835	29	1	2708	1	KIAA1632	18	43467730	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	12541400	43467730	34609518	891	15669										
TCEB3C	162699	broad.mit.edu	37	chr18	44555295	44555295	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccagggaaagcagcttcctCctggagcgctggcgcggaga	15	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:44555295C>A	uc010xdb.1	-	1	1155	c.919G>T	c.(919-921)GAG>TAG	p.E307*	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GCAGCTTCCTCCTGGAGCGCT	0.637													1	0	3.52763e-06	0.00499	3.67509e-06	19	864										A	44555295	C	A	44555295	4	1	54	1	0	0	0	0	0	1	0	0	15680	864	30	3	2368	3	TCEB3C	18	44555295	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1087565	44555295	33521953	892	15670										
LIPG	9388	broad.mit.edu	37	chr18	47101785	47101785	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaggggccgacatccacaaGaggctctctccggacgatgc	13	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:47101785G>C	uc002ldv.2	+	5	870	c.618G>C	c.(616-618)AAG>AAC	p.K206N	LIPG_uc002ldu.1_Missense_Mutation_p.K206N|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	206					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						ACATCCACAAGAGGCTCTCTC	0.567													0	0	0	0.010729	0	10	50										C	47101785	G	C	47101785	3	2	54	1	0	0	0	0	1	0	0	0	8823	933	33	1	636	1	LIPG	18	47101785	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2546490	47101785	30975463	893	15671										
MBD1	4152	broad.mit.edu	37	chr18	47799277	47799277	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttctcctccttgtcctcctCtgggtcaggtggctcttgct	10	14	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:47799277C>G	uc010dow.1	-	14	2070	c.1633G>C	c.(1633-1635)GAG>CAG	p.E545Q	MBD1_uc002lef.2_Missense_Mutation_p.E250Q|MBD1_uc002leg.2_Missense_Mutation_p.E495Q|MBD1_uc010xdi.1_Missense_Mutation_p.E596Q|MBD1_uc002leh.3_Missense_Mutation_p.E489Q|MBD1_uc002len.2_Missense_Mutation_p.E499Q|MBD1_uc002lei.3_Missense_Mutation_p.E545Q|MBD1_uc002lej.3_Missense_Mutation_p.E443Q|MBD1_uc002lek.3_Missense_Mutation_p.E496Q|MBD1_uc002lel.3_Missense_Mutation_p.E476Q|MBD1_uc002lem.3_Missense_Mutation_p.E545Q|MBD1_uc010xdj.1_Missense_Mutation_p.E443Q|MBD1_uc010xdk.1_Missense_Mutation_p.E570Q|MBD1_uc010dox.1_Missense_Mutation_p.E476Q|MBD1_uc002leo.2_Missense_Mutation_p.E499Q	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	545	TRD.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTGTCCTCCTCTGGGTCAGGT	0.582													0	0	0	0.010818	0	29	127										G	47799277	C	G	47799277	3	3	54	1	0	0	0	0	1	0	0	0	9342	922	32	1	390	1	MBD1	18	47799277	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	697492	47799277	30277971	894	15672										
NARS	4677	broad.mit.edu	37	chr18	55273932	55273932	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accaagtcctccaaccggttCaggaggtcgtcaaaagtcag	10	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:55273932C>G	uc002lgs.2	-	10	1281	c.1053G>C	c.(1051-1053)CTG>CTC	p.L351L	NARS_uc002lgt.2_Silent_p.L350L|NARS_uc010xea.1_Silent_p.L102L	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	351					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)	CCAACCGGTTCAGGAGGTCGT	0.493													0	0	0	0.004656	0	21	130										G	55273932	C	G	55273932	2	3	54	1	0	0	0	0	0	0	0	1	10170	813	29	1		1	NARS	18	55273932	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	7474655	55273932	22803316	895	15673										
ALPK2	115701	broad.mit.edu	37	chr18	56247584	56247584	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttataaggatgttccttctCatcaatctgatttgcccttt	5	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:56247584C>T	uc002lhj.3	-	4	638	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	142							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TGTTCCTTCTCATCAATCTGA	0.493													0	0	0	0.008871	0	14	93										T	56247584	C	T	56247584	3	4	54	1	0	0	0	0	1	0	0	0	545	835	29	1	6128	1	ALPK2	18	56247584	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	973652	56247584	21829664	896	15674										
CBLN2	147381	broad.mit.edu	37	chr18	70205477	70205477	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccccatgaggttgcctctCtcaagtttgagatgcacttt	8	13	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:70205477C>T	uc002lku.2	-	4	844	c.609G>A	c.(607-609)GAG>GAA	p.E203E	CBLN2_uc002lkv.2_Silent_p.E203E	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	203	C1q.					integral to membrane					0		Esophageal squamous(42;0.131)				GGTTGCCTCTCTCAAGTTTGA	0.527													0	0	0	0.00308	0	7	76										T	70205477	C	T	70205477	2	4	54	1	0	0	0	0	0	0	0	1	2705	912	32	1		1	CBLN2	18	70205477	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	13957893	70205477	7871771	897	15675										
ZNF407	55628	broad.mit.edu	37	chr18	72343136	72343136	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tatgggcaaaagaggtttttCagaatcatcgaactctgata	9	6	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:72343136C>T	uc002llw.2	+	1	218	c.161C>T	c.(160-162)TCA>TTA	p.S54L	ZNF407_uc010xfc.1_Missense_Mutation_p.S54L|ZNF407_uc010dqu.1_Missense_Mutation_p.S54L|ZNF407_uc002llu.2_Missense_Mutation_p.S53L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGAGGTTTTTCAGAATCATCG	0.413													0	0	0	0.001984	0	7	24										T	72343136	C	T	72343136	3	4	54	1	0	0	0	0	1	0	0	0	17884	838	29	1	163	1	ZNF407	18	72343136	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2137659	72343136	5734112	898	15676										
GALR1	2587	broad.mit.edu	37	chr18	74962762	74962762	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccgacctggcctacctgctCttctgcatccccttccaggc	8	19	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr18:74962762C>G	uc002lms.3	+	1	755	c.258C>G	c.(256-258)CTC>CTG	p.L86L		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	86	Helical; Name=2; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CCTACCTGCTCTTCTGCATCC	0.622													0	0	0	0.00361	0	55	200										G	74962762	C	G	74962762	2	3	54	1	0	0	0	0	0	0	0	1	6227	900	32	1		1	GALR1	18	74962762	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2619626	74962762	3114486	899	15677										
PALM	5064	broad.mit.edu	37	chr19	746781	746781	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccaggacctcgacatgaaGaagcaccgttgtaaatgctg	10	12	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:746781G>A	uc002lpm.1	+	9	1325	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	PALM_uc002lpn.1_Silent_p.K333K|PALM_uc010xfu.1_Silent_p.K242K	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	377					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		TCGACATGAAGAAGCACCGTT	0.701													0	0	0	0.001168	0	4	25										A	746781	G	A	746781	2	1	54	1	0	0	0	0	0	0	0	1	11408	933	33	1		1	PALM	19	746781	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		746781	58382202	900	15678										
LPPR3	79948	broad.mit.edu	37	chr19	814710	814710	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accgacacatagaccgcggcGaaggctgacagcgtggcgtg	15	12	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:814710G>A	uc002lpx.1	-	6	703	c.639C>T	c.(637-639)TTC>TTT	p.F213F	LPPR3_uc010dru.1_Silent_p.F125F|LPPR3_uc002lpw.1_Silent_p.F213F|LPPR3_uc002lpy.1_5'UTR	NM_024888	NP_079164	Q6T4P5	LPPR3_HUMAN	plasticity-related protein 2	213	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity				0						AGACCGCGGCGAAGGCTGACA	0.697													0	0	0	0.001855	0	11	90										A	814710	G	A	814710	2	1	54	1	0	0	0	0	0	0	0	1	8926	1049	37	1		1	LPPR3	19	814710	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	67929	814710	58314273	901	15679										
SBNO2	22904	broad.mit.edu	37	chr19	1123979	1123979	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggggtgctgtgggagggcaGaaagtcctcgaagcctgcaa	17	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:1123979G>A	uc002lrk.3	-	6	722	c.484C>T	c.(484-486)CTG>TTG	p.L162L	SBNO2_uc002lrj.3_Silent_p.L105L|SBNO2_uc010dse.2_Silent_p.L155L|SBNO2_uc010xgj.1_Silent_p.L105L|SBNO2_uc010dsf.2_Silent_p.L105L	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	162					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGAGGGCAGAAAGTCCTCG	0.657													0	0	0	0.004482	0	6	58										A	1123979	G	A	1123979	2	1	54	1	0	0	0	0	0	0	0	1	13863	933	33	1		1	SBNO2	19	1123979	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	309269	1123979	58005004	902	15680										
APC2	10297	broad.mit.edu	37	chr19	1461973	1461973	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcgtccaggagtccaccctGaagagcgtgctgagcgccct	12	15	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:1461973G>A	uc002lsr.1	+	14	1858	c.1650G>A	c.(1648-1650)CTG>CTA	p.L550L	APC2_uc002lss.1_Silent_p.L132L|APC2_uc002lst.1_Silent_p.L550L|APC2_uc002lsu.1_Silent_p.L549L|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	550	ARM 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCCACCCTGAAGAGCGTGC	0.632													0	0	0	0.008291	0	7	60										A	1461973	G	A	1461973	2	1	54	1	0	0	0	0	0	0	0	1	764	1277	45	1		1	APC2	19	1461973	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	337994	1461973	57667010	903	15681										
APC2	10297	broad.mit.edu	37	chr19	1462069	1462069	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcgccctgggcttcctggtGagcaccctgacctacaagtg	13	14	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:1462069G>T	uc002lsr.1	+	14	1954	c.1746G>T	c.(1744-1746)GTG>GTT	p.V582V	APC2_uc002lss.1_Silent_p.V164V|APC2_uc002lst.1_Silent_p.V582V|APC2_uc002lsu.1_Silent_p.V581V|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	582	ARM 4.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCCTGGTGAGCACCCTGA	0.637													1	0	2.39556e-15	0.00278	2.57008e-15	18	115										T	1462069	G	T	1462069	2	4	54	1	0	0	0	0	0	0	0	1	764	1277	45	3		3	APC2	19	1462069	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	96	1462069	57666914	904	15682										
ATP8B3	148229	broad.mit.edu	37	chr19	1811570	1811570	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgcccctctgcctggggagtCtcccatcccagctctgatca	9	17	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:1811570C>T	uc002ltw.2	-	2	400	c.166G>A	c.(166-168)GAC>AAC	p.D56N	ATP8B3_uc002ltv.2_Missense_Mutation_p.D3N|ATP8B3_uc002ltx.2_Intron|ATP8B3_uc002ltz.1_Missense_Mutation_p.D3N	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	56	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGGGAGTCTCCCATCCCA	0.637													0	0	0	0.004482	0	3	57										T	1811570	C	T	1811570	3	4	54	1	0	0	0	0	1	0	0	0	1196	913	32	1	3896	1	ATP8B3	19	1811570	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	349501	1811570	57317413	905	15683										
DOT1L	84444	broad.mit.edu	37	chr19	2222186	2222186	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcctctcccgcccaccagctCtcctccagtccccggcttgg	8	22	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:2222186C>G	uc002lvb.3	+	24	3054	c.3018C>G	c.(3016-3018)CTC>CTG	p.L1006L	DOT1L_uc002lvc.1_Silent_p.L300L|DOT1L_uc002lve.1_3'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1006						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCACCAGCTCTCCTCCAGTC	0.697													0	0	0	0.002299	0	19	125										G	2222186	C	G	2222186	2	3	54	1	0	0	0	0	0	0	0	1	4709	900	32	1		1	DOT1L	19	2222186	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	410616	2222186	56906797	906	15684										
ZNF556	80032	broad.mit.edu	37	chr19	2876263	2876263	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gacaagcacaacaccaaggaGagacatttgaggtgagttgt	12	7	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:2876263G>A	uc002lwp.1	+	3	390	c.303G>A	c.(301-303)GAG>GAA	p.E101E	ZNF556_uc002lwq.2_Silent_p.E101E	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACCAAGGAGAGACATTTGA	0.264													0	0	0	0.00245	0	14	79										A	2876263	G	A	2876263	2	1	54	1	0	0	0	0	0	0	0	1	17984	933	33	1		1	ZNF556	19	2876263	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	654077	2876263	56252720	907	15685										
TLE2	7089	broad.mit.edu	37	chr19	3017853	3017853	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttaccctgctcggggctctCtccactgacagattgggaat	10	13	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:3017853C>T	uc002lww.2	-	8	818	c.555G>A	c.(553-555)GAG>GAA	p.E185E	TLE2_uc010xhb.1_5'UTR|TLE2_uc010dth.2_Silent_p.E186E|TLE2_uc010xhc.1_Intron|TLE2_uc010dti.2_Silent_p.E199E|TLE2_uc010xhd.1_Intron	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	185	Gly/Pro-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGGGGCTCTCTCCACTGACA	0.522													0	0	0	0.001984	0	6	48										T	3017853	C	T	3017853	2	4	54	1	0	0	0	0	0	0	0	1	15936	912	32	1		1	TLE2	19	3017853	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	141590	3017853	56111130	908	15686										
TLE2	7089	broad.mit.edu	37	chr19	3019709	3019709	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agactcaccccgatgaggctGttcagctcccccacggtgac	10	16	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:3019709G>C	uc002lww.2	-	6	620	c.357C>G	c.(355-357)AAC>AAG	p.N119K	TLE2_uc010xhb.1_5'UTR|TLE2_uc010dth.2_Missense_Mutation_p.N119K|TLE2_uc010xhc.1_Missense_Mutation_p.N64K|TLE2_uc010dti.2_Missense_Mutation_p.N132K|TLE2_uc010xhd.1_Intron	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	119	Gln-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGATGAGGCTGTTCAGCTCCC	0.647													0	0	0	0.006214	0	9	43										C	3019709	G	C	3019709	3	2	54	1	0	0	0	0	1	0	0	0	15936	1368	48	4	1937	4	TLE2	19	3019709	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1856	3019709	56109274	909	15687										
CREB3L3	84699	broad.mit.edu	37	chr19	4154998	4154998	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgagacacgtggagctgggcGagggctggggtcacgtcaag	19	8	2	1	rs143652660		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:4154998G>A	uc002lzl.2	+	2	246	c.130G>A	c.(130-132)GAG>AAG	p.E44K	CREB3L3_uc002lzm.2_Missense_Mutation_p.E35K|CREB3L3_uc010xib.1_Missense_Mutation_p.E35K|CREB3L3_uc010xic.1_Missense_Mutation_p.E35K	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	44	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCTGGGCGAGGGCTGGGG	0.642													0	0	0	0.004289	0	28	181										A	4154998	G	A	4154998	3	1	54	1	0	0	0	0	1	0	0	0	3858	1059	37	1	136	1	CREB3L3	19	4154998	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1135289	4154998	54973985	910	15688										
MPND	84954	broad.mit.edu	37	chr19	4345945	4345945	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccacctggctccggctgcaCcagctgcacacgcctgccac	10	20	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:4345945C>G	uc002mae.2	+	3	565	c.498C>G	c.(496-498)CAC>CAG	p.H166Q	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Missense_Mutation_p.H166Q|MPND_uc002maf.2_Missense_Mutation_p.H166Q|MPND_uc002mah.2_Missense_Mutation_p.H54Q|MPND_uc002mai.2_Missense_Mutation_p.H54Q	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	166							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGCTGCACCAGCTGCACA	0.632													0	0	0	0.004672	0	3	34										G	4345945	C	G	4345945	3	3	54	1	0	0	0	0	1	0	0	0	9731	506	18	4	508	4	MPND	19	4345945	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	190947	4345945	54783038	911	15689										
UBXN6	80700	broad.mit.edu	37	chr19	4446589	4446589	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccaggggcgagggctggaaGacgcggcgctgcctgtccag	19	12	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:4446589G>C	uc002man.1	-	8	924	c.828C>G	c.(826-828)GTC>GTG	p.V276V	UBXN6_uc010dty.1_Silent_p.V180V|UBXN6_uc002mam.1_Silent_p.V223V	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	276						microtubule organizing center|nucleus	protein binding				0						AGGGCTGGAAGACGCGGCGCT	0.672													0	0	0	0.00245	0	11	111										C	4446589	G	C	4446589	2	2	54	1	0	0	0	0	0	0	0	1	16914	929	33	1		1	UBXN6	19	4446589	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	100644	4446589	54682394	912	15690										
LRG1	116844	broad.mit.edu	37	chr19	4538477	4538477	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggcagtttccggaggcggttCccagacaggtccagatgccc	14	13	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:4538477C>T	uc002mau.2	-	2	530	c.519G>A	c.(517-519)GGG>GGA	p.G173G	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	173	LRR 4.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGGCGGTTCCCAGACAGGT	0.622													0	0	0	0.010771	0	34	218										T	4538477	C	T	4538477	2	4	54	1	0	0	0	0	0	0	0	1	8942	842	30	1		1	LRG1	19	4538477	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	91888	4538477	54590506	913	15691										
INSR	3643	broad.mit.edu	37	chr19	7166277	7166277	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcatactgggtccagggcttGagaccccgcatcagccaccc	11	16	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:7166277G>C	uc002mgd.1	-	8	1858	c.1749C>G	c.(1747-1749)CTC>CTG	p.L583L	INSR_uc002mge.1_Silent_p.L583L|INSR_uc002mgf.2_Silent_p.L583L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	583					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCAGGGCTTGAGACCCCGCA	0.557													0	0	0	0.004482	0	8	70										C	7166277	G	C	7166277	2	2	54	1	0	0	0	0	0	0	0	1	7773	1277	45	1		1	INSR	19	7166277	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2627800	7166277	51962706	914	15692										
ARHGEF18	23370	broad.mit.edu	37	chr19	7523533	7523533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctacacgagctccaaagagGacaggaacgcctggatggcc	12	12	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:7523533G>A	uc002mgi.2	+	9	2006	c.1753G>A	c.(1753-1755)GAC>AAC	p.D585N	ARHGEF18_uc010xjm.1_Missense_Mutation_p.D427N|ARHGEF18_uc002mgh.2_Missense_Mutation_p.D427N|ARHGEF18_uc002mgj.1_Missense_Mutation_p.D228N	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	585	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				CTCCAAAGAGGACAGGAACGC	0.582													0	0	0	0.006214	0	8	46										A	7523533	G	A	7523533	3	1	54	1	0	0	0	0	1	0	0	0	901	1174	41	1	1787	1	ARHGEF18	19	7523533	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	357256	7523533	51605450	915	15693										
LRRC8E	80131	broad.mit.edu	37	chr19	7960596	7960596	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacctcaccgtggccatgctCatgattggggtctttggctg	12	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:7960596C>G	uc002mir.2	+	2	209	c.108C>G	c.(106-108)CTC>CTG	p.L36L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	36	Helical; (Potential).					integral to membrane				lung(1)|pancreas(1)	2						TGGCCATGCTCATGATTGGGG	0.642													0	0	0	0.004007	0	14	117										G	7960596	C	G	7960596	2	3	54	1	0	0	0	0	0	0	0	1	9025	813	29	1		1	LRRC8E	19	7960596	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	437063	7960596	51168387	916	15694										
FBN3	84467	broad.mit.edu	37	chr19	8175799	8175799	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagcggaacattccaggcagGttctcacagctcccaaatgc	9	14	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:8175799G>A	uc002mjf.2	-	33	4284	c.4263C>T	c.(4261-4263)AAC>AAT	p.N1421N		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1421	EGF-like 22; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TTCCAGGCAGGTTCTCACAGC	0.622													0	0	0	0.00874	0	38	205										A	8175799	G	A	8175799	2	1	54	1	0	0	0	0	0	0	0	1	5704	1252	44	2		2	FBN3	19	8175799	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	215203	8175799	50953184	917	15695										
ANGPTL4	51129	broad.mit.edu	37	chr19	8438619	8438619	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtttggcacctgcagccattCcaacctcaacggccagtact	8	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:8438619C>G	uc002mjq.1	+	7	1265	c.1070C>G	c.(1069-1071)TCC>TGC	p.S357C	ANGPTL4_uc002mjr.1_Missense_Mutation_p.S319C|ANGPTL4_uc010xkc.1_Missense_Mutation_p.S190C	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	357	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						TGCAGCCATTCCAACCTCAAC	0.607													0	0	0	0.00361	0	66	501										G	8438619	C	G	8438619	3	3	54	1	0	0	0	0	1	0	0	0	616	855	30	1	1096	1	ANGPTL4	19	8438619	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	262820	8438619	50690364	918	15696										
ADAMTS10	81794	broad.mit.edu	37	chr19	8661945	8661945	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgccatggccgctgtggttCacgatggatttctgccactt	11	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:8661945C>T	uc002mkj.1	-	8	1240	c.966G>A	c.(964-966)GTG>GTA	p.V322V	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	322	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CGCTGTGGTTCACGATGGATT	0.572													0	0	0	0.00499	0	15	155										T	8661945	C	T	8661945	2	4	54	1	0	0	0	0	0	0	0	1	256	813	29	1		1	ADAMTS10	19	8661945	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	223326	8661945	50467038	919	15697										
MUC16	94025	broad.mit.edu	37	chr19	9002669	9002669	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtggctgccccatccttctCaggcctagggagggcagatg	15	12	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:9002669C>T	uc002mkp.2	-	51	40351	c.40147G>A	c.(40147-40149)GAG>AAG	p.E13383K	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.E200K|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13385	Extracellular (Potential).|SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCATCCTTCTCAGGCCTAGGG	0.547													0	0	0	0.001168	0	5	37										T	9002669	C	T	9002669	3	4	54	1	0	0	0	0	1	0	0	0	9973	835	29	1	3512	1	MUC16	19	9002669	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	340724	9002669	50126314	920	15698										
MUC16	94025	broad.mit.edu	37	chr19	9062124	9062124	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctcagtggtagcaccactgGgcacttcagaaaggacagtg	12	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:9062124G>T	uc002mkp.2	-	3	25526	c.25322C>A	c.(25321-25323)CCC>CAC	p.P8441H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8443	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCACCACTGGGCACTTCAGA	0.522													1	0	3.27435e-08	0.00245	3.44725e-08	14	71										T	9062124	G	T	9062124	3	4	54	1	0	0	0	0	1	0	0	0	9973	1232	43	4	18529	4	MUC16	19	9062124	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	59455	9062124	50066859	921	15699										
MUC16	94025	broad.mit.edu	37	chr19	9091500	9091500	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttccattgacctggggactCagcgatgggctggttctttg	14	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:9091500C>T	uc002mkp.2	-	1	519	c.315G>A	c.(313-315)CTG>CTA	p.L105L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	105	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGGGGACTCAGCGATGGGC	0.537													0	0	0	0.002299	0	22	130										T	9091500	C	T	9091500	2	4	54	1	0	0	0	0	0	0	0	1	9973	813	29	1		1	MUC16	19	9091500	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	29376	9091500	50037483	922	15700										
ZNF846	162993	broad.mit.edu	37	chr19	9873968	9873968	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagttttacctagtataatGagattcttgtagttctccaa	6	8	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:9873968G>A	uc002mmb.1	-	3	663	c.132C>T	c.(130-132)CTC>CTT	p.L44L	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_5'UTR	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTAGTATAATGAGATTCTTGT	0.408													0	0	0	0.010729	0	8	61										A	9873968	G	A	9873968	2	1	54	1	0	0	0	0	0	0	0	1	18189	1277	45	1		1	ZNF846	19	9873968	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	782468	9873968	49255015	923	15701										
OLFM2	93145	broad.mit.edu	37	chr19	9967498	9967498	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctcacccggctatccgcactGggggccatcgtgtcagtcat	11	15	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:9967498G>A	uc002mmp.2	-	5	700	c.672C>T	c.(670-672)CCC>CCT	p.P224P	OLFM2_uc002mmo.2_Silent_p.P146P	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	224	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2						TATCCGCACTGGGGGCCATCG	0.662													0	0	0	0.00245	0	10	53										A	9967498	G	A	9967498	2	1	54	1	0	0	0	0	0	0	0	1	10853	1335	47	2		2	OLFM2	19	9967498	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	93530	9967498	49161485	924	15702										
PDE4A	5141	broad.mit.edu	37	chr19	10577958	10577959	+	Missense_Mutation	DNP	GG	GG	TA													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcatccctggaggccgagctGgaggcagtgtatttgacaca							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:10577958_10577959GG>TA	uc002moj.2	+	15	2430_2431	c.2322_2323GG>TA	c.(2320-2325)CTGGAG>CTTAAG	p.E775K	PDE4A_uc002mok.2_Missense_Mutation_p.E749K|PDE4A_uc002mol.2_Missense_Mutation_p.E714K|PDE4A_uc002mom.2_Missense_Mutation_p.E536K|PDE4A_uc002mon.2_Missense_Mutation_p.E230K|PDE4A_uc002moo.2_3'UTR	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	775					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	AGGCCGAGCTGGAGGCAGTGTA	0.594													0	0	0	0.004672	0	19	165										TA	10577959	GG	TA	10577958	3	4	54	1	0	0	0	0	1	0	0	0	11639	1335	47	4	2837	4	PDE4A	19	10577958	Missense_Mutation	DNP	GG	TCGA-DK-A2I4-01A-11D-A21A-08	610460	10577958	48551025	925	15703										
KANK2	25959	broad.mit.edu	37	chr19	11286644	11286644	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agggccaagcaggctgagatGaggtcagggcttagctccat	15	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:11286644G>A	uc010dxv.2	-	10	2340	c.1782C>T	c.(1780-1782)CTC>CTT	p.L594L	KANK2_uc002mqm.2_Silent_p.L602L|KANK2_uc002mqo.3_Silent_p.L594L|KANK2_uc002mqp.1_Silent_p.L403L	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	594											0						AGGCTGAGATGAGGTCAGGGC	0.607													0	0	0	0.006122	0	14	152										A	11286644	G	A	11286644	2	1	54	1	0	0	0	0	0	0	0	1	7977	1277	45	1		1	KANK2	19	11286644	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	708686	11286644	47842339	926	15704										
RAB3D	9545	broad.mit.edu	37	chr19	11448060	11448060	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgtgggcctgcctgggtgtCtccagctgatgccatcttgg	14	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:11448060C>T	uc002mqy.2	-	2	254	c.16G>A	c.(16-18)GAC>AAC	p.D6N		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	6					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						GCCTGGGTGTCTCCAGCTGAT	0.498													0	0	0	0.00278	0	22	170										T	11448060	C	T	11448060	3	4	54	1	0	0	0	0	1	0	0	0	12934	913	32	1	659	1	RAB3D	19	11448060	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	161416	11448060	47680923	927	15705										
ZNF564	163050	broad.mit.edu	37	chr19	12639430	12639430	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcccgcatcacatctctgtaGagtttcttctgggaaggatc	9	11	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:12639430G>C	uc002mty.2	-	2	294	c.84C>G	c.(82-84)CTC>CTG	p.L28L	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATCTCTGTAGAGTTTCTTCT	0.453													0	0	0	0.010729	0	10	79										C	12639430	G	C	12639430	2	2	54	1	0	0	0	0	0	0	0	1	17992	929	33	1		1	ZNF564	19	12639430	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1191370	12639430	46489553	928	15706										
ZNF791	163049	broad.mit.edu	37	chr19	12739580	12739580	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acactggagaaaaaccctatGagtgtaaggaatgtgcaaaa	10	6	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:12739580G>T	uc002mua.2	+	4	1399	c.1237G>T	c.(1237-1239)GAG>TAG	p.E413*	ZNF791_uc010xml.1_Nonsense_Mutation_p.E381*|ZNF791_uc010dyu.1_Nonsense_Mutation_p.E304*|ZNF791_uc010xmm.1_Nonsense_Mutation_p.E304*	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	413	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAAACCCTATGAGTGTAAGGA	0.393													1	0	0.00448238	0.004482	0.00457775	7	75										T	12739580	G	T	12739580	4	4	54	1	0	0	0	0	0	1	0	0	18160	1291	45	3	1251	3	ZNF791	19	12739580	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	100150	12739580	46389403	929	15707										
ZNF791	163049	broad.mit.edu	37	chr19	12740000	12740000	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaattatgagaaacctcttGaatgtaagcaatgtggaaaa	8	5	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:12740000G>A	uc002mua.2	+	4	1819	c.1657G>A	c.(1657-1659)GAA>AAA	p.E553K	ZNF791_uc010xml.1_Missense_Mutation_p.E521K|ZNF791_uc010dyu.1_Missense_Mutation_p.E444K|ZNF791_uc010xmm.1_Missense_Mutation_p.E444K	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	553	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GAAACCTCTTGAATGTAAGCA	0.353													0	0	0	0.004007	0	13	46										A	12740000	G	A	12740000	3	1	54	1	0	0	0	0	1	0	0	0	18160	1291	45	1	1671	1	ZNF791	19	12740000	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	420	12740000	46388983	930	15708										
MAST1	22983	broad.mit.edu	37	chr19	12969528	12969528	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgagactcggcgccacctCtgcatggtcatggaatatgt	11	10	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:12969528C>T	uc002mvm.2	+	12	1469	c.1341C>T	c.(1339-1341)CTC>CTT	p.L447L	MAST1_uc002mvk.2_Silent_p.L443L	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	447	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GGCGCCACCTCTGCATGGTCA	0.622													0	0	0	0.00499	0	12	69										T	12969528	C	T	12969528	2	4	54	1	0	0	0	0	0	0	0	1	9324	900	32	1		1	MAST1	19	12969528	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	229528	12969528	46159455	931	15709										
GCDH	2639	broad.mit.edu	37	chr19	13007041	13007041	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcacgaactcgcctatggccGatctgtttgtagtgtgggct	12	10	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:13007041G>A	uc002mvq.2	+	8	735	c.658G>A	c.(658-660)GAT>AAT	p.D220N	GCDH_uc010xms.1_Missense_Mutation_p.D187N|GCDH_uc002mvp.2_Missense_Mutation_p.D220N|GCDH_uc010xmt.1_Intron|GCDH_uc010xmu.1_Missense_Mutation_p.D176N	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	220					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						GCCTATGGCCGATCTGTTTGT	0.622													0	0	0	0.011902	0	38	182										A	13007041	G	A	13007041	3	1	54	1	0	0	0	0	1	0	0	0	6287	1058	37	1	684	1	GCDH	19	13007041	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	37513	13007041	46121942	932	15710										
CALR	811	broad.mit.edu	37	chr19	13054368	13054368	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggtcaagtctggcaccatCtttgacaacttcctcatcac	6	14	5	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:13054368C>T	uc002mvu.2	+	8	1058	c.978C>T	c.(976-978)ATC>ATT	p.I326I	CALR_uc002mvv.2_5'Flank|RAD23A_uc002mvw.1_5'Flank|RAD23A_uc002mvx.1_5'Flank|RAD23A_uc002mvz.1_5'Flank|RAD23A_uc002mwa.1_5'Flank|RAD23A_uc002mvy.1_5'Flank|RAD23A_uc010xmw.1_5'Flank	NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	326	C-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGGCACCATCTTTGACAACT	0.527													0	0	0	0.00499	0	15	106										T	13054368	C	T	13054368	2	4	54	1	0	0	0	0	0	0	0	1	2592	903	32	1		1	CALR	19	13054368	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	47327	13054368	46074615	933	15711										
RAD23A	5886	broad.mit.edu	37	chr19	13059132	13059132	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gagaggacaagagcccatcaGaggaatccgcccccacgacg	12	14	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:13059132G>C	uc002mvw.1	+	3	485	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	RAD23A_uc002mvx.1_Missense_Mutation_p.E126Q|RAD23A_uc002mvz.1_Missense_Mutation_p.E126Q|RAD23A_uc002mwa.1_Missense_Mutation_p.E126Q|RAD23A_uc002mvy.1_5'UTR|RAD23A_uc010xmw.1_5'UTR	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	126					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						GAGCCCATCAGAGGAATCCGC	0.652								NER					0	0	0	0.008291	0	6	106										C	13059132	G	C	13059132	3	2	54	1	0	0	0	0	1	0	0	0	12982	943	33	1	386	1	RAD23A	19	13059132	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4764	13059132	46069851	934	15712										
OR10H3	26532	broad.mit.edu	37	chr19	15853149	15853149	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaggttctgccctctaagctCctaatggccagtttggtggt	11	10	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:15853149C>G	uc010xoq.1	+	1	947	c.947C>G	c.(946-948)TCC>TGC	p.S316C		NM_013938	NP_039226	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H,	316	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTCTAAGCTCCTAATGGCCA	0.299													0	0	0	0.009096	0	4	32										G	15853149	C	G	15853149	3	3	54	1	0	0	0	0	1	0	0	0	10907	855	30	1	949	1	OR10H3	19	15853149	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2794017	15853149	43275834	935	15713										
FCHO1	23149	broad.mit.edu	37	chr19	17883460	17883460	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccacccggcacaggtgcatGaggaatttaagcagaacatc	10	12	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:17883460G>A	uc010ebb.2	+	10	889	c.700G>A	c.(700-702)GAG>AAG	p.E234K	FCHO1_uc002nhg.3_Missense_Mutation_p.E234K|FCHO1_uc002nhh.2_Missense_Mutation_p.E234K|FCHO1_uc010xpw.1_Missense_Mutation_p.E184K|FCHO1_uc010ebc.1_Missense_Mutation_p.E241K	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	234										breast(1)	1						ACAGGTGCATGAGGAATTTAA	0.587													0	0	0	0.012319	0	18	115										A	17883460	G	A	17883460	3	1	54	1	0	0	0	0	1	0	0	0	5787	1291	45	1	730	1	FCHO1	19	17883460	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2030311	17883460	41245523	936	15714										
JUND	3727	broad.mit.edu	37	chr19	18391519	18391519	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgtgtccatgtcgatgggcGacaacggcgggctctcgccg	16	13	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:18391519G>C	uc002nip.2	-	1	914	c.776C>G	c.(775-777)TCG>TGG	p.S259W	hsa-mir-3188|MI0014232_5'Flank	NM_005354	NP_005345	P17535	JUND_HUMAN	jun D proto-oncogene	259					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						GTCGATGGGCGACAACGGCGG	0.721													0	0	0	0.003163	0	6	38										C	18391519	G	C	18391519	3	2	54	1	0	0	0	0	1	0	0	0	7971	1059	37	1	271	1	JUND	19	18391519	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	508059	18391519	40737464	937	15715										
LRRC25	126364	broad.mit.edu	37	chr19	18507660	18507660	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaattcaggcacgtggcactGaactccgcgttccagtccac	9	14	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:18507660G>A	uc002niw.2	-	1	756	c.114C>T	c.(112-114)TTC>TTT	p.F38F	LRRC25_uc002nix.2_Silent_p.F38F	NM_145256	NP_660299	Q8N386	LRC25_HUMAN	leucine rich repeat containing 25 precursor	38	Extracellular (Potential).					integral to membrane					0						ACGTGGCACTGAACTCCGCGT	0.617													0	0	0	0.003163	0	15	79										A	18507660	G	A	18507660	2	1	54	1	0	0	0	0	0	0	0	1	8980	1281	45	1		1	LRRC25	19	18507660	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	116141	18507660	40621323	938	15716										
ELL	8178	broad.mit.edu	37	chr19	18632761	18632761	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggtagctctcgaaggccctCagggcactgtcggtgagctt	14	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:18632761C>T	uc002njh.2	-	1	177	c.105G>A	c.(103-105)CTG>CTA	p.L35L	ELL_uc010ebq.2_5'UTR	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	35					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		CGAAGGCCCTCAGGGCACTGT	0.701			T	MLL	AL								0	0	0	0.00308	0	6	24										T	18632761	C	T	18632761	2	4	54	1	0	0	0	0	0	0	0	1	5062	813	29	1		1	ELL	19	18632761	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	125101	18632761	40496222	939	15717										
UBA52	7311	broad.mit.edu	37	chr19	18684188	18684188	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgacaccattgagaatgtCaaagccaaaattcaagacaa	7	8	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:18684188C>G	uc002njr.2	+	2	192	c.78C>G	c.(76-78)GTC>GTG	p.V26V	UBA52_uc002njs.2_Silent_p.V26V|UBA52_uc002njt.2_Silent_p.V26V	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor	26	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						TTGAGAATGTCAAAGCCAAAA	0.552													0	0	0	0.008291	0	8	47										G	18684188	C	G	18684188	2	3	54	1	0	0	0	0	0	0	0	1	16828	813	29	1		1	UBA52	19	18684188	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	51427	18684188	40444795	940	15718										
DDX49	54555	broad.mit.edu	37	chr19	19033503	19033503	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtccacctgatccagcgcttCcaggatgagcacgaggactg	12	13	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:19033503C>T	uc002nkq.1	+	6	783	c.726C>T	c.(724-726)TTC>TTT	p.F242F	HOMER3_uc002nko.1_Intron|HOMER3_uc002nkp.1_Intron|DDX49_uc002nkr.1_RNA|DDX49_uc002nks.1_Silent_p.F135F|DDX49_uc002nkt.1_Silent_p.F124F	NM_019070	NP_061943	Q9Y6V7	DDX49_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	242	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			Epithelial(12;0.0289)			TCCAGCGCTTCCAGGATGAGC	0.627													0	0	0	0.002299	0	19	143										T	19033503	C	T	19033503	2	4	54	1	0	0	0	0	0	0	0	1	4366	854	30	1		1	DDX49	19	19033503	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	349315	19033503	40095480	941	15719										
C19orf2	8725	broad.mit.edu	37	chr19	30505917	30505917	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aagttctgttggaagcatctGaagaaactggaaagagggtt	13	4	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:30505917G>A	uc002nsr.2	+	11	1579	c.1549G>A	c.(1549-1551)GAA>AAA	p.E517K	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Missense_Mutation_p.E477K|C19orf2_uc002nst.2_Missense_Mutation_p.E441K	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	517					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGCATCTGAAGAAACTGG	0.433													0	0	0	0.010729	0	9	60										A	30505917	G	A	30505917	3	1	54	1	0	0	0	0	1	0	0	0	1911	1291	45	1	1591	1	C19orf2	19	30505917	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	11472414	30505917	28623066	942	15720										
ANKRD27	84079	broad.mit.edu	37	chr19	33135288	33135288	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aatgttcgatggaaagaggcGatgttcctgtcaaatcgctc	11	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:33135288G>A	uc002ntn.1	-	5	624	c.468C>T	c.(466-468)ATC>ATT	p.I156I	ANKRD27_uc002nto.1_Silent_p.I156I	NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	156					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					GGAAAGAGGCGATGTTCCTGT	0.532													0	0	0	0.00361	0	74	281										A	33135288	G	A	33135288	2	1	54	1	0	0	0	0	0	0	0	1	655	1048	37	1		1	ANKRD27	19	33135288	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2629371	33135288	25993695	943	15721										
ZNF792	126375	broad.mit.edu	37	chr19	35449696	35449696	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgtgaaccctcttatgctGaatgaggttggagcttcggc	13	8	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:35449696G>A	uc002nxh.1	-	4	1450	c.1063C>T	c.(1063-1065)CAG>TAG	p.Q355*		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	355	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CTCTTATGCTGAATGAGGTTG	0.507													0	0	0	0.001855	0	12	48										A	35449696	G	A	35449696	4	1	54	1	0	0	0	0	0	1	0	0	18161	1299	45	1	839	1	ZNF792	19	35449696	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2314408	35449696	23679287	944	15722										
LGI4	163175	broad.mit.edu	37	chr19	35625566	35625566	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccagccagcagcagcagcaGaatgcctgcccctcccatgc	9	19	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:35625566G>T	uc002nxx.2	-	1	613	c.19C>A	c.(19-21)CTG>ATG	p.L7M	LGI4_uc002nxy.1_Intron|LGI4_uc002nxz.1_5'Flank|LGI4_uc002nya.2_Missense_Mutation_p.L7M	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	7						extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			AGCAGCAGCAGAATGCCTGCC	0.687													1	0	0.00198382	0.001984	0.00202762	6	37										T	35625566	G	T	35625566	3	4	54	1	0	0	0	0	1	0	0	0	8754	933	33	3	1630	3	LGI4	19	35625566	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	175870	35625566	23503417	945	15723										
MLL4	9757	broad.mit.edu	37	chr19	36219890	36219890	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacatttcctcttcagcattCcagggcaaggatccggctgc	9	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:36219890C>T	uc010eei.2	+	22	4692	c.4692C>T	c.(4690-4692)TTC>TTT	p.F1564F		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1564					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTTCAGCATTCCAGGGCAAGG	0.602													0	0	0	0.007413	0	16	151										T	36219890	C	T	36219890	2	4	54	1	0	0	0	0	0	0	0	1	9623	854	30	1		1	MLL4	19	36219890	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	594324	36219890	22909093	946	15724										
THAP8	199745	broad.mit.edu	37	chr19	36545042	36545042	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgcgctgcgctcacttgtaGaagctcacagggcggttgtc	13	13	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:36545042G>C	uc002oda.1	-	1	623	c.78C>G	c.(76-78)TTC>TTG	p.F26L	WDR62_uc002odd.2_5'Flank|WDR62_uc002odc.2_5'Flank|THAP8_uc010xtb.1_Intron|THAP8_uc010xtc.1_RNA|WDR62_uc010eer.2_5'Flank|WDR62_uc002odb.2_5'Flank	NM_152658	NP_689871	Q8NA92	THAP8_HUMAN	THAP domain containing 8	26	THAP-type.						DNA binding|metal ion binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTCACTTGTAGAAGCTCACAG	0.672													0	0	0	0.006214	0	8	58										C	36545042	G	C	36545042	3	2	54	1	0	0	0	0	1	0	0	0	15847	933	33	1	762	1	THAP8	19	36545042	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	325152	36545042	22583941	947	15725										
ZNF260	339324	broad.mit.edu	37	chr19	37005801	37005801	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catctgaatagaaactttttCacattcataaggtttctctc	4	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:37005801C>T	uc002oee.1	-	4	1184	c.340G>A	c.(340-342)GAA>AAA	p.E114K	ZNF260_uc002oed.1_Missense_Mutation_p.E111K|ZNF260_uc010eey.1_Missense_Mutation_p.E111K|ZNF260_uc002oef.1_Missense_Mutation_p.E111K	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	114					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GAAACTTTTTCACATTCATAA	0.388													0	0	0	0.001855	0	13	60										T	37005801	C	T	37005801	3	4	54	1	0	0	0	0	1	0	0	0	17799	835	29	1	902	1	ZNF260	19	37005801	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	460759	37005801	22123182	948	15726										
ZNF529	57711	broad.mit.edu	37	chr19	37038544	37038544	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acatttgtaagttttctcatCagtatggattttctgatgtc	7	6	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:37038544C>T	uc002oeh.3	-	5	1118	c.916G>A	c.(916-918)GAT>AAT	p.D306N	ZNF529_uc010xth.1_Missense_Mutation_p.D306N|ZNF529_uc010xti.1_Missense_Mutation_p.D288N|ZNF529_uc002oeg.3_Missense_Mutation_p.D201N	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	273					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					GTTTTCTCATCAGTATGGATT	0.388													0	0	0	0.001855	0	13	57										T	37038544	C	T	37038544	3	4	54	1	0	0	0	0	1	0	0	0	17967	826	29	1	779	1	ZNF529	19	37038544	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	32743	37038544	22090439	949	15727										
ZNF607	84775	broad.mit.edu	37	chr19	38190626	38190626	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcaggttcctcactagtatGaattgtttgatgtaccatga	8	7	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:38190626G>A	uc002ohc.1	-	5	1002	c.406C>T	c.(406-408)CAT>TAT	p.H136Y	ZNF607_uc002ohb.1_Missense_Mutation_p.H135Y	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	136	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			TCACTAGTATGAATTGTTTGA	0.373													0	0	0	0.00245	0	11	83										A	38190626	G	A	38190626	3	1	54	1	0	0	0	0	1	0	0	0	18030	1290	45	1	1688	1	ZNF607	19	38190626	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1152082	38190626	20938357	950	15728										
SIPA1L3	23094	broad.mit.edu	37	chr19	38692599	38692599	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacagccacctgagcctggaGaggggacccccgacccccag	12	18	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:38692599G>T	uc002ohk.2	+	20	5591	c.5082G>T	c.(5080-5082)GAG>GAT	p.E1694D		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1694					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TGAGCCTGGAGAGGGGACCCC	0.647													1	0	1.33834e-09	0.007413	1.41591e-09	14	136										T	38692599	G	T	38692599	3	4	54	1	0	0	0	0	1	0	0	0	14331	933	33	3	5152	3	SIPA1L3	19	38692599	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	501973	38692599	20436384	951	15729										
CATSPERG	57828	broad.mit.edu	37	chr19	38860798	38860798	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcccctcccaacccctgcaGaggagtggacacgagcacct	9	17	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:38860798G>A	uc002oih.3	+	28	3201	c.3114_splice	c.e28-1	p.R1038_splice	CATSPERG_uc002oig.3_Splice_Site_p.R998_splice|CATSPERG_uc002oif.3_Splice_Site_p.R678_splice|CATSPERG_uc010efw.2_Splice_Site	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma						cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						AACCCCTGCAGAGGAGTGGAC	0.607													0	0	0	0.00333	0	21	79										A	38860798	G	A	38860798	5	1	54	1	0	0	0	0	0	0	1	0	2692	956	33	1	3219	1	CATSPERG	19	38860798	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	168199	38860798	20268185	952	15730										
EIF3K	27335	broad.mit.edu	37	chr19	39114742	39114742	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agttcaacccagccttctttCagaccacggtcaccgcccag	7	17	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:39114742C>T	uc002oiz.1	+	3	371	c.184C>T	c.(184-186)CAG>TAG	p.Q62*	EIF3K_uc010xuh.1_Nonsense_Mutation_p.Q62*|EIF3K_uc010xui.1_5'UTR	NM_013234	NP_037366	Q9UBQ5	EIF3K_HUMAN	eukaryotic translation initiation factor 3,	62					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex|nucleus	protein binding|ribosome binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGCCTTCTTTCAGACCACGGT	0.562													0	0	0	0.001855	0	10	115										T	39114742	C	T	39114742	4	4	54	1	0	0	0	0	0	1	0	0	5021	827	29	1	194	1	EIF3K	19	39114742	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	253944	39114742	20014241	953	15731										
LGALS4	3960	broad.mit.edu	37	chr19	39292471	39292471	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtccaccctctggaaggccGagaggcgatgggcaaagtca	14	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:39292471G>A	uc002ojg.2	-	10	1119	c.905C>T	c.(904-906)TCG>TTG	p.S302L		NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	302	Galectin 2.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CTGGAAGGCCGAGAGGCGATG	0.532													0	0	0	0.001855	0	11	85										A	39292471	G	A	39292471	3	1	54	1	0	0	0	0	1	0	0	0	8745	1059	37	1	70	1	LGALS4	19	39292471	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	177729	39292471	19836512	954	15732										
PAF1	54623	broad.mit.edu	37	chr19	39879228	39879228	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggtgcatagtccatctcctCctcctggtcccgctttcgtt	8	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:39879228C>T	uc002old.2	-	10	1004	c.829G>A	c.(829-831)GAG>AAG	p.E277K	PAF1_uc002ole.1_Missense_Mutation_p.E267K|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	277					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCCATCTCCTCCTCCTGGTCC	0.522													0	0	0	0.008361	0	29	94										T	39879228	C	T	39879228	3	4	54	1	0	0	0	0	1	0	0	0	11383	864	30	1	786	1	PAF1	19	39879228	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	586757	39879228	19249755	955	15733										
PAF1	54623	broad.mit.edu	37	chr19	39879261	39879261	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctttcgtttcttcaacgtctCttctacaggcaggaaatagg	8	10	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:39879261C>T	uc002old.2	-	10	971	c.796G>A	c.(796-798)GAG>AAG	p.E266K	PAF1_uc002ole.1_Missense_Mutation_p.E256K|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	266					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TTCAACGTCTCTTCTACAGGC	0.512													0	0	0	0.00499	0	16	68										T	39879261	C	T	39879261	3	4	54	1	0	0	0	0	1	0	0	0	11383	922	32	1	819	1	PAF1	19	39879261	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	33	39879261	19249722	956	15734										
DMRTC2	63946	broad.mit.edu	37	chr19	42354706	42354706	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcatcccaggctcctcgtgTgaccccttctgtgcccccca	7	19	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:42354706T>C	uc002ors.2	+	8	1012	c.929T>C	c.(928-930)GTG>GCG	p.V310A	DMRTC2_uc002orr.1_Missense_Mutation_p.V238A|DMRTC2_uc010xwe.1_Missense_Mutation_p.V361A	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	310	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						GCTCCTCGTGTGACCCCTTCT	0.632													0	0	0	0.003954	0	21	74										C	42354706	T	C	42354706	3	2	54	1	0	0	0	0	1	0	0	0	4591	1696	59	5	955	5	DMRTC2	19	42354706	Missense_Mutation	SNP	T	TCGA-DK-A2I4-01A-11D-A21A-08	2475445	42354706	16774277	957	15735										
GRIK5	2901	broad.mit.edu	37	chr19	42509942	42509942	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atctgggtgaggttgcagttGaggcgccggtggtattcgtt	17	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:42509942G>A	uc002osj.1	-	16	2231	c.2196C>T	c.(2194-2196)CTC>CTT	p.L732L	GRIK5_uc002osi.1_Silent_p.L304L	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	732	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGTTGCAGTTGAGGCGCCGGT	0.622													0	0	0	0.001984	0	6	50										A	42509942	G	A	42509942	2	1	54	1	0	0	0	0	0	0	0	1	6777	1277	45	1		1	GRIK5	19	42509942	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	155236	42509942	16619041	958	15736										
ZNF526	116115	broad.mit.edu	37	chr19	42728868	42728868	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggagctggtgccgggtgctGaggggcccttccagtgtggt	19	10	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:42728868G>A	uc002osz.1	+	3	469	c.313G>A	c.(313-315)GAG>AAG	p.E105K		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	105					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GCCGGGTGCTGAGGGGCCCTT	0.622													0	0	0	0.001368	0	10	137										A	42728868	G	A	42728868	3	1	54	1	0	0	0	0	1	0	0	0	17964	1291	45	1	315	1	ZNF526	19	42728868	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	218926	42728868	16400115	959	15737										
CIC	23152	broad.mit.edu	37	chr19	42798383	42798383	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgcaagatgagaagacgctcCagctgcagctcggagcccaa	12	13	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:42798383C>A	uc002otf.1	+	18	4294	c.4254C>A	c.(4252-4254)TCC>TCA	p.S1418S		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GAAGACGCTCCAGCTGCAGCT	0.617			T	DUX4	soft tissue sarcoma								1	0	2.24893e-16	0.009718	2.41676e-16	39	127										A	42798383	C	A	42798383	2	1	54	1	0	0	0	0	0	0	0	1	3424	581	21	4		4	CIC	19	42798383	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	69515	42798383	16330600	960	15738										
CD177	57126	broad.mit.edu	37	chr19	43864482	43864482	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acttggctcaagaacccactGattggaccacatcgaatacc	7	13	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:43864482G>A	uc002owi.2	+	6	727	c.685G>A	c.(685-687)GAT>AAT	p.D229N	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	229					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				AGAACCCACTGATTGGACCAC	0.542													0	0	0	0.001168	0	5	29										A	43864482	G	A	43864482	3	1	54	1	0	0	0	0	1	0	0	0	2971	1290	45	1	707	1	CD177	19	43864482	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1066099	43864482	15264501	961	15739										
PLAUR	5329	broad.mit.edu	37	chr19	44160637	44160637	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggttggggctcaccttcttCaccttcctggatccagtggg	12	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:44160637C>T	uc002oxf.1	-	4	696	c.466G>A	c.(466-468)GAA>AAA	p.E156K	PLAUR_uc002oxd.1_Missense_Mutation_p.E156K|PLAUR_uc002oxe.1_Missense_Mutation_p.E151K|PLAUR_uc002oxg.1_Missense_Mutation_p.E156K	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	156	UPAR/Ly6 2.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	TCACCTTCTTCACCTTCCTGG	0.478													0	0	0	0.00874	0	37	295										T	44160637	C	T	44160637	3	4	54	1	0	0	0	0	1	0	0	0	12023	835	29	1	653	1	PLAUR	19	44160637	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	296155	44160637	14968346	962	15740										
ZNF221	7638	broad.mit.edu	37	chr19	44470216	44470216	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgtttctgtctttgatcttCatcaacaatcacactcagga	5	10	7	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:44470216C>T	uc002oxx.2	+	6	890	c.562C>T	c.(562-564)CAT>TAT	p.H188Y	ZNF221_uc010ejb.1_Missense_Mutation_p.H188Y|ZNF221_uc010xws.1_Missense_Mutation_p.H188Y	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	188	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				CTTTGATCTTCATCAACAATC	0.408													0	0	0	0.009535	0	25	88										T	44470216	C	T	44470216	3	4	54	1	0	0	0	0	1	0	0	0	17772	826	29	1	576	1	ZNF221	19	44470216	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	309579	44470216	14658767	963	15741										
ZFP112	7771	broad.mit.edu	37	chr19	44832181	44832181	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atatatatggtctttctccaGaatggacactctgatgactc	7	9	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:44832181G>A	uc010ejj.2	-	5	2260	c.2147C>T	c.(2146-2148)TCT>TTT	p.S716F	ZFP112_uc002ozc.3_Missense_Mutation_p.S710F|ZFP112_uc010xwy.1_Missense_Mutation_p.S733F|ZFP112_uc010xwz.1_Missense_Mutation_p.S715F	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	716					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TCTTTCTCCAGAATGGACACT	0.453													0	0	0	0.006214	0	7	44										A	44832181	G	A	44832181	3	1	54	1	0	0	0	0	1	0	0	0	17635	942	33	1	598	1	ZFP112	19	44832181	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	361965	44832181	14296802	964	15742										
CBLC	23624	broad.mit.edu	37	chr19	45287647	45287647	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caggtgctcctggagggacaGaaggacggcttgtgagtctc	16	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:45287647G>A	uc002ozs.2	+	5	969	c.906G>A	c.(904-906)CAG>CAA	p.Q302Q	CBLC_uc010ejt.2_Intron	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	302	SH2-like.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TGGAGGGACAGAAGGACGGCT	0.483			M		AML						OREG0025542	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	21	98										A	45287647	G	A	45287647	2	1	54	1	0	0	0	0	0	0	0	1	2702	933	33	1		1	CBLC	19	45287647	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	455466	45287647	13841336	965	15743										
CLPTM1	1209	broad.mit.edu	37	chr19	45490661	45490661	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agttgtacgagcagtcagatGaggagcaggactcggtgaag	16	6	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:45490661G>A	uc002pai.2	+	8	1033	c.1018G>A	c.(1018-1020)GAG>AAG	p.E340K	CLPTM1_uc010ejv.1_Missense_Mutation_p.E238K|CLPTM1_uc010xxf.1_Missense_Mutation_p.E238K|CLPTM1_uc010xxg.1_Missense_Mutation_p.E326K	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	340	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GCAGTCAGATGAGGAGCAGGA	0.632													0	0	0	0.004007	0	10	84										A	45490661	G	A	45490661	3	1	54	1	0	0	0	0	1	0	0	0	3554	1291	45	1	1048	1	CLPTM1	19	45490661	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	203014	45490661	13638322	966	15744										
GPR4	2828	broad.mit.edu	37	chr19	46094942	46094942	+	Missense_Mutation	SNP	G	G	C													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagatgtacagcaggtcggcGatgctgaggttcatcaggta							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:46094942G>C	uc002pcm.2	-	2	1128	c.183C>G	c.(181-183)ATC>ATG	p.I61M	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	61	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GCAGGTCGGCGATGCTGAGGT	0.647													0	0	0	0.003163	0	13	176										C	46094942	G	C	46094942	3	2	54	1	0	0	0	0	1	0	0	0	6694	1048	37	1	909	1	GPR4	19	46094942	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	604281	46094942	13034041	967	15745	78	2								
GPR4	2828	broad.mit.edu	37	chr19	46094948	46094948	+	Silent	SNP	G	G	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tacagcaggtcggcgatgctGaggttcatcaggtagacgcc							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:46094948G>A	uc002pcm.2	-	2	1122	c.177C>T	c.(175-177)CTC>CTT	p.L59L	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	59	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		CGGCGATGCTGAGGTTCATCA	0.642													0	0	0	0.001368	0	9	175										A	46094948	G	A	46094948	2	1	54	1	0	0	0	0	0	0	0	1	6694	1277	45	1		1	GPR4	19	46094948	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6	46094948	13034035	968	15746	78	2								
GIPR	2696	broad.mit.edu	37	chr19	46174547	46174547	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgtgcccacccccaggcctCgcctgtaacgggtccttcga	10	19	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:46174547C>T	uc002pcu.1	+	4	276	c.177C>T	c.(175-177)CTC>CTT	p.L59L	GIPR_uc002pct.1_Silent_p.L59L|GIPR_uc010xxp.1_Intron|GIPR_uc010xxq.1_RNA	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	59	Extracellular (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		CCCCAGGCCTCGCCTGTAACG	0.667													0	0	0	0.004656	0	24	185										T	46174547	C	T	46174547	2	4	54	1	0	0	0	0	0	0	0	1	6395	871	31	1		1	GIPR	19	46174547	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	79599	46174547	12954436	969	15747										
EHD2	30846	broad.mit.edu	37	chr19	48244378	48244378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgaggagggctcggacgacGaggccgagtgggtggtgacc	21	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:48244378G>A	uc002phj.3	+	6	1571	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	EHD2_uc010xyu.1_Missense_Mutation_p.E305K|EHD2_uc010xyv.1_Missense_Mutation_p.E124K	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	441					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		CTCGGACGACGAGGCCGAGTG	0.657													0	0	0	0.004007	0	12	89										A	48244378	G	A	48244378	3	1	54	1	0	0	0	0	1	0	0	0	4978	1059	37	1	1339	1	EHD2	19	48244378	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2069831	48244378	10884605	970	15748										
PPFIA3	8541	broad.mit.edu	37	chr19	49652018	49652018	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaaagtcagacccagatccGaggtgagtagagcctaaggg	14	8	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:49652018G>A	uc002pmr.2	+	25	3439	c.3107G>A	c.(3106-3108)CGA>CAA	p.R1036Q	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.R895Q|PPFIA3_uc002pmt.2_Missense_Mutation_p.R175Q|PPFIA3_uc002pmu.1_Missense_Mutation_p.R85Q	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	1036	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACCCAGATCCGAGGTGAGTAG	0.587													0	0	0	0.001168	0	5	45										A	49652018	G	A	49652018	3	1	54	1	0	0	0	0	1	0	0	0	12311	1058	37	1	3201	1	PPFIA3	19	49652018	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1407640	49652018	9476965	971	15749										
CD37	951	broad.mit.edu	37	chr19	49840236	49840236	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggaatcttcaccatgggcatCgccctcctgggttgtgtggg	14	11	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:49840236C>T	uc002pnd.2	+	3	334	c.213C>T	c.(211-213)ATC>ATT	p.I71I	uc002pnb.1_Intron|CD37_uc002pnc.2_RNA|CD37_uc010yam.1_Silent_p.I71I|CD37_uc010yan.1_Silent_p.I3I|CD37_uc002pnf.3_Silent_p.I43I|CD37_uc002pne.2_Silent_p.I3I	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	71	Helical; (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		CCATGGGCATCGCCCTCCTGG	0.617													0	0	0	0.00499	0	16	63										T	49840236	C	T	49840236	2	4	54	1	0	0	0	0	0	0	0	1	3008	874	31	1		1	CD37	19	49840236	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	188218	49840236	9288747	972	15750										
NUP62	23636	broad.mit.edu	37	chr19	50413062	50413062	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctccaaaattaaacccgctCatggctccggactctggtgg	9	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:50413062C>T	uc002pqx.2	-	2	107	c.3G>A	c.(1-3)ATG>ATA	p.M1I	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.M1I|NUP62_uc002pqz.2_Missense_Mutation_p.M1I|NUP62_uc002pra.2_Missense_Mutation_p.M1I|NUP62_uc002prb.2_Missense_Mutation_p.M1I|NUP62_uc002prc.2_Missense_Mutation_p.M1I	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	1	15 X 9 AA approximate repeats.|1.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TAAACCCGCTCATGGCTCCGG	0.547													0	0	0	0.001368	0	7	58										T	50413062	C	T	50413062	3	4	54	1	0	0	0	0	1	0	0	0	10768	826	29	1	1569	1	NUP62	19	50413062	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	572826	50413062	8715921	973	15751										
ETFB	2109	broad.mit.edu	37	chr19	51848565	51848565	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtcctccacactgatcacaGagagcttggaggtcaggtcc	12	12	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:51848565G>A	uc002pwh.2	-	6	760	c.668C>T	c.(667-669)TCT>TTT	p.S223F	ETFB_uc002pwg.2_Missense_Mutation_p.S314F	NM_001985	NP_001976	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	223					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		ACTGATCACAGAGAGCTTGGA	0.592													0	0	0	0.010729	0	11	88										A	51848565	G	A	51848565	3	1	54	1	0	0	0	0	1	0	0	0	5270	942	33	1	103	1	ETFB	19	51848565	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1435503	51848565	7280418	974	15752										
ZNF808	388558	broad.mit.edu	37	chr19	53056414	53056414	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcaacagggcaaggcaataGagaagtgatccacacaggga	13	8	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:53056414G>C	uc010epq.1	+	5	422	c.245G>C	c.(244-246)AGA>ACA	p.R82T	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	82	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CAAGGCAATAGAGAAGTGATC	0.363													0	0	0	0.003954	0	23	163										C	53056414	G	C	53056414	3	2	54	1	0	0	0	0	1	0	0	0	18170	942	33	1	255	1	ZNF808	19	53056414	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1207849	53056414	6072569	975	15753										
ZNF600	162966	broad.mit.edu	37	chr19	53270485	53270485	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctggtgtttccttaagagtGagctacaattaaaggctttg	10	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:53270485G>A	uc002qab.3	-	3	810	c.524C>T	c.(523-525)TCA>TTA	p.S175L		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	175	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CCTTAAGAGTGAGCTACAATT	0.373													0	0	0	0.006122	0	15	74										A	53270485	G	A	53270485	3	1	54	1	0	0	0	0	1	0	0	0	18027	1294	45	1	1648	1	ZNF600	19	53270485	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	214071	53270485	5858498	976	15754										
ZNF160	90338	broad.mit.edu	37	chr19	53572607	53572607	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	attgcacttgtaaggtttctCtccagtgtgaattctccaat	7	9	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:53572607C>G	uc010eqk.2	-	7	1596	c.1180G>C	c.(1180-1182)GAG>CAG	p.E394Q	ZNF160_uc002qaq.3_Missense_Mutation_p.E394Q|ZNF160_uc002qar.3_Missense_Mutation_p.E394Q	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	394					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		TAAGGTTTCTCTCCAGTGTGA	0.398													0	0	0	0.001855	0	13	149										G	53572607	C	G	53572607	3	3	54	1	0	0	0	0	1	0	0	0	17736	922	32	1	1280	1	ZNF160	19	53572607	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	302122	53572607	5556376	977	15755										
ZNF347	84671	broad.mit.edu	37	chr19	53643596	53643596	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggcttgcaaggtttgaactCtgactttagaactttccaca	8	9	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:53643596C>G	uc002qbb.1	-	5	2554	c.2485G>C	c.(2485-2487)GAG>CAG	p.E829Q	ZNF347_uc010eql.1_Missense_Mutation_p.E830Q|ZNF347_uc002qbc.1_Missense_Mutation_p.E830Q	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	829					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		GGTTTGAACTCTGACTTTAGA	0.398													0	0	0	0.003755	0	29	112										G	53643596	C	G	53643596	3	3	54	1	0	0	0	0	1	0	0	0	17858	922	32	1	38	1	ZNF347	19	53643596	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	70989	53643596	5485387	978	15756										
MBOAT7	79143	broad.mit.edu	37	chr19	54692090	54692090	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccagggctgggcctgaatgaGggcccaggtcccgaggatgg	18	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:54692090G>A	uc002qdq.2	-	4	453	c.187C>T	c.(187-189)CTC>TTC	p.L63F	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Missense_Mutation_p.L45F|MBOAT7_uc002qdr.2_Missense_Mutation_p.L63F|MBOAT7_uc002qds.2_Missense_Mutation_p.P32L|MBOAT7_uc010yen.1_Missense_Mutation_p.P32L|MBOAT7_uc002qdt.3_Missense_Mutation_p.L63F|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	63	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCTGAATGAGGGCCCAGGTC	0.602													0	0	0	0.001368	0	10	158										A	54692090	G	A	54692090	3	1	54	1	0	0	0	0	1	0	0	0	9358	1000	35	2	1259	2	MBOAT7	19	54692090	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1048494	54692090	4436893	979	15757										
TTYH1	57348	broad.mit.edu	37	chr19	54942276	54942276	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgacccctcctcgccccgcaGaagcctctgctgtccttgga	9	19	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:54942276G>A	uc002qfq.2	+	10	1125	c.1033_splice	c.e10-1	p.K345_splice	TTYH1_uc010yey.1_Splice_Site_p.E375_splice|TTYH1_uc002qfr.2_Splice_Site_p.K345_splice|TTYH1_uc002qft.2_Splice_Site_p.K345_splice|TTYH1_uc002qfu.1_Splice_Site_p.K257_splice	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1						cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TCGCCCCGCAGAAGCCTCTGC	0.403													0	0	0	0.008361	0	22	104										A	54942276	G	A	54942276	5	1	54	1	0	0	0	0	0	0	1	0	16736	956	33	1	1070	1	TTYH1	19	54942276	Splice_Site	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	250186	54942276	4186707	980	15758										
KIR2DL1	3802	broad.mit.edu	37	chr19	55286739	55286739	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accatctatccagggaagggGaggcccatgaacgtaggctc	13	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:55286739G>A	uc002qhb.1	+	4	531	c.493G>A	c.(493-495)GAG>AAG	p.E165K	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_RNA|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Missense_Mutation_p.E165K	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	165	Extracellular (Potential).|Ig-like C2-type 2.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		CAGGGAAGGGGAGGCCCATGA	0.612													0	0	0	0.00632	0	23	54										A	55286739	G	A	55286739	3	1	54	1	0	0	0	0	1	0	0	0	8316	1175	41	1	507	1	KIR2DL1	19	55286739	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	344463	55286739	3842244	981	15759										
NLRP7	199713	broad.mit.edu	37	chr19	55452917	55452917	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtgttgaccagaatttctgCcagtttcttgccatcagcct	9	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:55452917C>T	uc002qih.3	-	2	239	c.163G>A	c.(163-165)GCA>ACA	p.A55T	NLRP7_uc002qig.3_Missense_Mutation_p.A55T|NLRP7_uc002qii.3_Missense_Mutation_p.A55T|NLRP7_uc010esk.2_Missense_Mutation_p.A55T|NLRP7_uc010esl.2_Missense_Mutation_p.A83T	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	55	DAPIN.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGAATTTCTGCCAGTTTCTTG	0.443													0	0	0	0.000602	0	3	70										T	55452917	C	T	55452917	3	4	54	1	0	0	0	0	1	0	0	0	10482	739	26	2	2990	2	NLRP7	19	55452917	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	166178	55452917	3676066	982	15760										
NLRP7	199713	broad.mit.edu	37	chr19	55453052	55453052	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgctccagaagggtctgcaGagtccactctagctggggcg	14	12	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:55453052G>A	uc002qih.3	-	2	104	c.28C>T	c.(28-30)CTG>TTG	p.L10L	NLRP7_uc002qig.3_Silent_p.L10L|NLRP7_uc002qii.3_Silent_p.L10L|NLRP7_uc010esk.2_Silent_p.L10L|NLRP7_uc010esl.2_Silent_p.L38L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	10	DAPIN.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGGGTCTGCAGAGTCCACTCT	0.483													0	0	0	0.001984	0	5	36										A	55453052	G	A	55453052	2	1	54	1	0	0	0	0	0	0	0	1	10482	933	33	1		1	NLRP7	19	55453052	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	135	55453052	3675931	983	15761										
SYT5	6861	broad.mit.edu	37	chr19	55686641	55686641	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccccgatggcgtcattgcGagagaagcggtcgaagtcgt	14	11	1	1	rs141073446		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:55686641G>A	uc002qjm.1	-	5	1667	c.607C>T	c.(607-609)CGC>TGC	p.R203C	SYT5_uc002qjp.2_Missense_Mutation_p.R200C|SYT5_uc002qjn.1_Missense_Mutation_p.R203C|SYT5_uc002qjo.1_Missense_Mutation_p.R203C	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	203	Cytoplasmic (Potential).|C2 1.				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GCGTCATTGCGAGAGAAGCGG	0.677													0	0	0	0.000602	0	3	41										A	55686641	G	A	55686641	3	1	54	1	0	0	0	0	1	0	0	0	15474	1058	37	1	569	1	SYT5	19	55686641	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	233589	55686641	3442342	984	15762										
NLRP11	204801	broad.mit.edu	37	chr19	56329303	56329303	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aatgatcttcctacaaagatCttccttacgcatcattgaaa	4	10	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:56329303C>G	uc010ygf.1	-	4	949	c.238G>C	c.(238-240)GAT>CAT	p.D80H	NLRP11_uc002qmb.2_Intron|NLRP11_uc002qmc.2_Intron|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	80	DAPIN.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTACAAAGATCTTCCTTACGC	0.463													0	0	0	0.004482	0	8	84										G	56329303	C	G	56329303	3	3	54	1	0	0	0	0	1	0	0	0	10473	913	32	1	2899	1	NLRP11	19	56329303	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	642662	56329303	2799680	985	15763										
NLRP4	147945	broad.mit.edu	37	chr19	56382323	56382323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaggactgaaaactctctgcGaggccttgaaacatccggac	10	11	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:56382323G>A	uc002qmd.3	+	7	2907	c.2485G>A	c.(2485-2487)GAG>AAG	p.E829K	NLRP4_uc002qmf.2_Missense_Mutation_p.E754K|NLRP4_uc010etf.2_Missense_Mutation_p.E604K	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	829	LRR 5.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AACTCTCTGCGAGGCCTTGAA	0.498													0	0	0	0.001368	0	9	86										A	56382323	G	A	56382323	3	1	54	1	0	0	0	0	1	0	0	0	10479	1059	37	1	2507	1	NLRP4	19	56382323	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	53020	56382323	2746660	986	15764										
GALP	85569	broad.mit.edu	37	chr19	56688513	56688513	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtccccctggtcctcctcctCgtcctcttgctgagcctggc	9	19	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:56688513C>T	uc002qmo.1	+	2	118	c.36C>T	c.(34-36)CTC>CTT	p.L12L	GALP_uc010eti.2_Silent_p.L12L	NM_033106	NP_149097	Q9UBC7	GALP_HUMAN	galanin-like peptide isoform 1 precursor	12					neuropeptide signaling pathway	extracellular region	hormone activity				0		Colorectal(82;0.000147)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0507)		TCCTCCTCCTCGTCCTCTTGC	0.622													0	0	0	0.001168	0	5	49										T	56688513	C	T	56688513	2	4	54	1	0	0	0	0	0	0	0	1	6226	871	31	1		1	GALP	19	56688513	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	306190	56688513	2440470	987	15765										
ZNF582	147948	broad.mit.edu	37	chr19	56895501	56895501	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaatgactaaaagccttccCacattccttacattcatatg	4	12	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:56895501C>T	uc002qmz.1	-	5	1444	c.1285G>A	c.(1285-1287)GGG>AGG	p.G429R	ZNF582_uc002qmy.2_Missense_Mutation_p.G460R	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	429	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		AAAGCCTTCCCACATTCCTTA	0.393													0	0	0	0.000602	0	5	49										T	56895501	C	T	56895501	3	4	54	1	0	0	0	0	1	0	0	0	18011	594	21	2	272	2	ZNF582	19	56895501	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	206988	56895501	2233482	988	15766										
USP29	57663	broad.mit.edu	37	chr19	57640824	57640824	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgacatctccattggaaccaGagcacagccagggtgaccca	10	13	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:57640824G>C	uc002qny.2	+	4	1137	c.781G>C	c.(781-783)GAG>CAG	p.E261Q		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	261					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTGGAACCAGAGCACAGCCA	0.478													0	0	0	0.000602	0	4	74										C	57640824	G	C	57640824	3	2	54	1	0	0	0	0	1	0	0	0	17056	943	33	1	783	1	USP29	19	57640824	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	745323	57640824	1488159	989	15767			6	63		4	4	430	G		5.907359e-07
USP29	57663	broad.mit.edu	37	chr19	57640872	57640872	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acaaagcccaggtgcctcttGactctcattcacagcaactg	7	14	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:57640872G>A	uc002qny.2	+	4	1185	c.829G>A	c.(829-831)GAC>AAC	p.D277N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	277					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.D277E(1)		lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGTGCCTCTTGACTCTCATTC	0.473													0	0	0	0.000602	0	5	30										A	57640872	G	A	57640872	3	1	54	1	0	0	0	0	1	0	0	0	17056	1290	45	1	831	1	USP29	19	57640872	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	48	57640872	1488111	990	15768			6	63		4	4	430	G		5.907359e-07
USP29	57663	broad.mit.edu	37	chr19	57641088	57641088	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtagtacaaagatcaagagaGaattacttgggaatgttaaa	10	3	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:57641088G>A	uc002qny.2	+	4	1401	c.1045G>A	c.(1045-1047)GAA>AAA	p.E349K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	349					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GATCAAGAGAGAATTACTTGG	0.378													0	0	0	0.001168	0	5	69										A	57641088	G	A	57641088	3	1	54	1	0	0	0	0	1	0	0	0	17056	943	33	1	1047	1	USP29	19	57641088	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	216	57641088	1487895	991	15769			6	63		4	4	430	G		5.907359e-07
USP29	57663	broad.mit.edu	37	chr19	57641253	57641253	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgggaaagaatgtggggatGaaaattcatctccacaaatg	11	6	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:57641253G>A	uc002qny.2	+	4	1566	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	404					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGTGGGGATGAAAATTCATC	0.393													0	0	0	0.001168	0	6	63										A	57641253	G	A	57641253	3	1	54	1	0	0	0	0	1	0	0	0	17056	1291	45	1	1212	1	USP29	19	57641253	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	165	57641253	1487730	992	15770			6	63		4	4	430	G		5.907359e-07
ZNF264	9422	broad.mit.edu	37	chr19	57723168	57723168	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttaagccctatgaatgcacaGaatgtgggaaaacctttatt	8	7	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:57723168G>C	uc002qob.2	+	4	1116	c.703G>C	c.(703-705)GAA>CAA	p.E235Q		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	235	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		TGAATGCACAGAATGTGGGAA	0.428													0	0	0	0.008291	0	9	77										C	57723168	G	C	57723168	3	2	54	1	0	0	0	0	1	0	0	0	17801	943	33	1	717	1	ZNF264	19	57723168	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	81915	57723168	1405815	993	15771										
ZNF530	348327	broad.mit.edu	37	chr19	58117277	58117277	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggagcatcaagagatttctgGatgagttcaaaccttcacca	9	9	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:58117277G>A	uc002qpk.2	+	3	604	c.384G>A	c.(382-384)TGG>TGA	p.W128*	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGATTTCTGGATGAGTTCAA	0.458													0	0	0	0.003163	0	14	35										A	58117277	G	A	58117277	4	1	54	1	0	0	0	0	0	1	0	0	17968	1183	41	1	394	1	ZNF530	19	58117277	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	394109	58117277	1011706	994	15772										
ZNF606	80095	broad.mit.edu	37	chr19	58490857	58490857	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcattgtagtcatagggtttCtctgcagtgtaagtgcttgt	11	6	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:58490857C>G	uc002qqw.2	-	7	1809	c.1191G>C	c.(1189-1191)GAG>GAC	p.E397D	ZNF606_uc010yhp.1_Missense_Mutation_p.E307D	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		CATAGGGTTTCTCTGCAGTGT	0.378													0	0	0	0.001984	0	5	55										G	58490857	C	G	58490857	3	3	54	1	0	0	0	0	1	0	0	0	18029	912	32	1	1191	1	ZNF606	19	58490857	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	373580	58490857	638126	995	15773										
TRIM28	10155	broad.mit.edu	37	chr19	59059693	59059693	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgcaccgggccctcaagatGattgtggatcccgtggagcc	13	13	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr19:59059693G>A	uc002qtg.1	+	8	1423	c.1134G>A	c.(1132-1134)ATG>ATA	p.M378I	TRIM28_uc010eut.1_Missense_Mutation_p.M296I|TRIM28_uc002qth.1_Missense_Mutation_p.M1I	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	378					epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCTCAAGATGATTGTGGATC	0.532													0	0	0	0.006214	0	8	102										A	59059693	G	A	59059693	3	1	54	1	0	0	0	0	1	0	0	0	16499	1290	45	1	1164	1	TRIM28	19	59059693	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	568836	59059693	69290	996	15774										
SOX12	6666	broad.mit.edu	37	chr20	306825	306825	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctgctgcaggactcggagaAgatcccgttcgtgcgggagg	17	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:306825A>T	uc002wdh.2	+	1	587	c.257A>T	c.(256-258)AAG>ATG	p.K86M		NM_006943	NP_008874	O15370	SOX12_HUMAN	SRY (sex determining region Y)-box 12	86	HMG box.				cell fate commitment|spinal cord development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|transcription regulatory region sequence-specific DNA binding				0		all_cancers(10;0.000331)|Lung NSC(37;0.0496)|all_lung(30;0.0831)|all_epithelial(17;0.0868)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GACTCGGAGAAGATCCCGTTC	0.612													0	0	0	0.001168	0	4	37										T	306825	A	T	306825	3	4	54	1	0	0	0	0	1	0	0	0	14943	72	3	5	259	5	SOX12	20	306825	Missense_Mutation	SNP	A	TCGA-DK-A2I4-01A-11D-A21A-08		306825	62718695	997	15775										
ANGPT4	51378	broad.mit.edu	37	chr20	853663	853663	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtgagtagctggggcccttGaagtagtgccagcggatgcc	16	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:853663G>T	uc002wei.2	-	9	1555	c.1452C>A	c.(1450-1452)TTC>TTA	p.F484L	ANGPT4_uc010zpn.1_3'UTR	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	484	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						TGGGGCCCTTGAAGTAGTGCC	0.577													1	0	5.50884e-06	0.001368	5.7299e-06	9	99										T	853663	G	T	853663	3	4	54	1	0	0	0	0	1	0	0	0	612	1281	45	3	63	3	ANGPT4	20	853663	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	546838	853663	62171857	998	15776										
UBOX5	22888	broad.mit.edu	37	chr20	3090835	3090835	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggcagggagcgttgcttctCacccaggcagggtcggcaca	16	12	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:3090835C>T	uc002whw.2	-	5	1713	c.1543G>A	c.(1543-1545)GAG>AAG	p.E515K	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.E461K|UBOX5_uc002why.1_Silent_p.*513*	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	515	RING-type.					nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						CGTTGCTTCTCACCCAGGCAG	0.607													0	0	0	0.008871	0	17	215										T	3090835	C	T	3090835	3	4	54	1	0	0	0	0	1	0	0	0	16891	835	29	1	86	1	UBOX5	20	3090835	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2237172	3090835	59934685	999	15777										
CENPB	1059	broad.mit.edu	37	chr20	3766965	3766965	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggccaccccgtacttgcgctCcgacgccaggatggcgcgct	13	17	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:3766965C>G	uc002wjk.2	-	1	373	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	56					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						TACTTGCGCTCCGACGCCAGG	0.642													0	0	0	0.008291	0	11	106										G	3766965	C	G	3766965	3	3	54	1	0	0	0	0	1	0	0	0	3227	864	30	1	1637	1	CENPB	20	3766965	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	676130	3766965	59258555	1000	15778										
MCM8	84515	broad.mit.edu	37	chr20	5939338	5939338	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tggagaaattcagagctttcCtcttccagatggaaaataca	8	8	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:5939338C>G	uc002wmi.2	+	7	1132	c.755C>G	c.(754-756)CCT>CGT	p.P252R	MCM8_uc002wmj.2_Missense_Mutation_p.P252R|MCM8_uc002wmk.2_Missense_Mutation_p.P252R|MCM8_uc002wml.2_Missense_Mutation_p.P252R|MCM8_uc010gbp.2_Missense_Mutation_p.P252R	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	252					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						CAGAGCTTTCCTCTTCCAGAT	0.388													0	0	0	0.001168	0	4	33										G	5939338	C	G	5939338	3	3	54	1	0	0	0	0	1	0	0	0	9393	681	24	4	777	4	MCM8	20	5939338	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2172373	5939338	57086182	1001	15779										
TMX4	56255	broad.mit.edu	37	chr20	7962990	7962990	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcagggttgctcagagatgcCttcttcagcctcctcaggct	11	13	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:7962990C>A	uc002wmx.1	-	8	1091	c.958G>T	c.(958-960)GGC>TGC	p.G320C		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	320	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane					0						TCAGAGATGCCTTCTTCAGCC	0.562													1	0	2.23348e-06	0.004007	2.33059e-06	13	80										A	7962990	C	A	7962990	3	1	54	1	0	0	0	0	1	0	0	0	16266	681	24	4	95	4	TMX4	20	7962990	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2023652	7962990	55062530	1002	15780										
SEL1L2	80343	broad.mit.edu	37	chr20	13830926	13830926	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgggcatctggactcgtttGagcagccatgtcgtacaatc	12	10	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:13830926G>T	uc010gcf.2	-	19	1940	c.1858C>A	c.(1858-1860)CAA>AAA	p.Q620K	SEL1L2_uc002woq.3_Missense_Mutation_p.Q481K|SEL1L2_uc010zrl.1_Missense_Mutation_p.Q507K|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	620	Extracellular (Potential).|Sel1-like 11.					integral to membrane	binding			ovary(2)	2						GGACTCGTTTGAGCAGCCATG	0.453													1	0	3.07112e-06	0.010729	3.20207e-06	10	74										T	13830926	G	T	13830926	3	4	54	1	0	0	0	0	1	0	0	0	14011	1299	45	3	216	3	SEL1L2	20	13830926	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5867936	13830926	49194594	1003	15781										
KIF16B	55614	broad.mit.edu	37	chr20	16359787	16359787	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggtactgtgcaagctgttCttctttttcttccatttcct	6	11	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:16359787C>T	uc002wpg.1	-	19	3018	c.2860G>A	c.(2860-2862)GAA>AAA	p.E954K	KIF16B_uc002wpe.1_Missense_Mutation_p.E336K|KIF16B_uc002wpf.1_Missense_Mutation_p.E336K|KIF16B_uc010gch.1_Missense_Mutation_p.E954K|KIF16B_uc010gci.1_Missense_Mutation_p.E954K|KIF16B_uc010gcj.1_Missense_Mutation_p.E965K	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	954	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GCAAGCTGTTCTTCTTTTTCT	0.438													0	0	0	0.004482	0	6	80										T	16359787	C	T	16359787	3	4	54	1	0	0	0	0	1	0	0	0	8278	922	32	1	1125	1	KIF16B	20	16359787	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2528861	16359787	46665733	1004	15782										
KIF16B	55614	broad.mit.edu	37	chr20	16359856	16359856	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctgagagggcctctgtcaaGaatttcaaatgctctctgct	10	10	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:16359856G>A	uc002wpg.1	-	19	2949	c.2791C>T	c.(2791-2793)CTT>TTT	p.L931F	KIF16B_uc002wpe.1_Missense_Mutation_p.L313F|KIF16B_uc002wpf.1_Missense_Mutation_p.L313F|KIF16B_uc010gch.1_Missense_Mutation_p.L931F|KIF16B_uc010gci.1_Missense_Mutation_p.L931F|KIF16B_uc010gcj.1_Missense_Mutation_p.L942F	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	931	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CCTCTGTCAAGAATTTCAAAT	0.433													0	0	0	0.009096	0	4	58										A	16359856	G	A	16359856	3	1	54	1	0	0	0	0	1	0	0	0	8278	942	33	1	1194	1	KIF16B	20	16359856	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	69	16359856	46665664	1005	15783										
CSRP2BP	57325	broad.mit.edu	37	chr20	18167964	18167964	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggacgtaacccttcacgtctCagcaagcaaccctgctatgc	8	15	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:18167964C>T	uc002wqj.2	+	11	2832	c.2210C>T	c.(2209-2211)TCA>TTA	p.S737L	CSRP2BP_uc002wqk.2_Missense_Mutation_p.S609L|CSRP2BP_uc010zru.1_Missense_Mutation_p.S608L	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	737	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						CTTCACGTCTCAGCAAGCAAC	0.403													0	0	0	0.006122	0	14	134										T	18167964	C	T	18167964	3	4	54	1	0	0	0	0	1	0	0	0	3968	838	29	1	2248	1	CSRP2BP	20	18167964	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1808108	18167964	44857556	1006	15784										
RALGAPA2	57186	broad.mit.edu	37	chr20	20621418	20621418	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggatgacatgactgctggGaaaccaggcaccaggcaagc	13	11	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:20621418G>A	uc002wrz.2	-	6	620	c.477C>T	c.(475-477)TTC>TTT	p.F159F	RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	159					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGACTGCTGGGAAACCAGGCA	0.498													0	0	0	0.004482	0	7	58										A	20621418	G	A	20621418	2	1	54	1	0	0	0	0	0	0	0	1	13014	1165	41	1		1	RALGAPA2	20	20621418	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2453454	20621418	42404102	1007	15785										
XRN2	22803	broad.mit.edu	37	chr20	21309207	21309207	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acattttcaggcaccacgtgCtaaaatgaaccagcagcgtt	8	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:21309207C>G	uc002wsf.1	+	4	421	c.326C>G	c.(325-327)GCT>GGT	p.A109G	XRN2_uc002wsg.1_Missense_Mutation_p.A33G|XRN2_uc010zsk.1_Missense_Mutation_p.A55G	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	109				A -> V (in Ref. 1; AAD55138/AAQ13577).	cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						GCACCACGTGCTAAAATGAAC	0.383													0	0	0	0.004672	0	3	23										G	21309207	C	G	21309207	3	3	54	1	0	0	0	0	1	0	0	0	17457	797	28	4	340	4	XRN2	20	21309207	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	687789	21309207	41716313	1008	15786										
GINS1	9837	broad.mit.edu	37	chr20	25388508	25388508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcgagctgcatcgcgcgcccGaagggcaactgcctgccttc	13	16	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:25388508G>A	uc002wuv.1	+	1	186	c.52G>A	c.(52-54)GAA>AAA	p.E18K	GINS1_uc010zte.1_RNA	NM_021067	NP_066545	Q14691	PSF1_HUMAN	GINS complex subunit 1	18					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				ovary(1)|central_nervous_system(1)	2						TCGCGCGCCCGAAGGGCAACT	0.687													0	0	0	0.00245	0	9	53										A	25388508	G	A	25388508	3	1	54	1	0	0	0	0	1	0	0	0	6387	1059	37	1	54	1	GINS1	20	25388508	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4079301	25388508	37637012	1009	15787										
XKR7	343702	broad.mit.edu	37	chr20	30585240	30585240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggacttcccaggagctgctgGagtatgagaccacagtgtag	14	9	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:30585240G>A	uc002wxe.2	+	3	1894	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	574						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGAGCTGCTGGAGTATGAGAC	0.617													0	0	0	0.006214	0	9	90										A	30585240	G	A	30585240	3	1	54	1	0	0	0	0	1	0	0	0	17433	1175	41	1	1730	1	XKR7	20	30585240	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5196732	30585240	32440280	1010	15788										
HCK	3055	broad.mit.edu	37	chr20	30681792	30681792	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttggcctggcccgggtcattGaggacaacgagtacacggct	14	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:30681792G>A	uc002wxh.2	+	11	1390	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	HCK_uc010gdy.2_Missense_Mutation_p.E386K|HCK_uc002wxi.2_Missense_Mutation_p.E385K	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	407	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCGGGTCATTGAGGACAACGA	0.552													0	0	0	0.012319	0	17	213										A	30681792	G	A	30681792	3	1	54	1	0	0	0	0	1	0	0	0	6994	1291	45	1	1267	1	HCK	20	30681792	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	96552	30681792	32343728	1011	15789										
ASXL1	171023	broad.mit.edu	37	chr20	31021257	31021257	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcggccagatctccgaaccaGagccagaaggaatctgtaca	10	12	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:31021257G>A	uc002wxs.2	+	11	1682	c.1256G>A	c.(1255-1257)AGA>AAA	p.R419K	ASXL1_uc010geb.2_Missense_Mutation_p.R310K	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	419					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTCCGAACCAGAGCCAGAAGG	0.517			F|N|Mis		MDS|CMML								0	0	0	0.010729	0	10	110										A	31021257	G	A	31021257	3	1	54	1	0	0	0	0	1	0	0	0	1066	942	33	1	1308	1	ASXL1	20	31021257	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	339465	31021257	32004263	1012	15790										
C20orf185	359710	broad.mit.edu	37	chr20	31661410	31661410	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtgctgaccgtggcatcctGaggctgagacatggccacca	13	12	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:31661410G>A	uc002wym.1	+	15	1430	c.1430G>A	c.(1429-1431)TGA>TAA	p.*477*		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	477					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						GTGGCATCCTGAGGCTGAGAC	0.532													0	0	0	0.008871	0	16	187										A	31661410	G	A	31661410	2	1	54	1	0	0	0	0	0	0	0	1	2097	1285	45	1		1	C20orf185	20	31661410	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	640153	31661410	31364110	1013	15791										
ZNF341	84905	broad.mit.edu	37	chr20	32354821	32354821	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctacttccagctcaagtctCacatgacccagcataagaat	5	14	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:32354821C>T	uc002wzy.2	+	9	1407	c.1387C>T	c.(1387-1389)CAC>TAC	p.H463Y	ZNF341_uc002wzx.2_Missense_Mutation_p.H456Y|ZNF341_uc010geq.2_Missense_Mutation_p.H373Y|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	463	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GCTCAAGTCTCACATGACCCA	0.562													0	0	0	0.00361	0	45	444										T	32354821	C	T	32354821	3	4	54	1	0	0	0	0	1	0	0	0	17854	826	29	1	1400	1	ZNF341	20	32354821	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	693411	32354821	30670699	1014	15792										
EDEM2	55741	broad.mit.edu	37	chr20	33722577	33722577	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cggctctcccagaggcgcatCaaagccactctggccacatc	9	17	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:33722577C>G	uc002xbo.2	-	6	766	c.666G>C	c.(664-666)TTG>TTC	p.L222F	EDEM2_uc010zuv.1_Missense_Mutation_p.L181F|EDEM2_uc010zus.1_5'UTR|EDEM2_uc002xbq.2_Missense_Mutation_p.L185F|EDEM2_uc010zut.1_Missense_Mutation_p.L181F|EDEM2_uc002xbp.2_Missense_Mutation_p.L70F|EDEM2_uc002xbn.2_Missense_Mutation_p.L70F|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_Intron	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	222					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			AGAGGCGCATCAAAGCCACTC	0.577													0	0	0	0.008291	0	11	127										G	33722577	C	G	33722577	3	3	54	1	0	0	0	0	1	0	0	0	4912	825	29	1	1094	1	EDEM2	20	33722577	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1367756	33722577	29302943	1015	15793										
FAM83C	128876	broad.mit.edu	37	chr20	33875386	33875386	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gggagccgtggttagggtctGacagttggcgatgtagggag	20	5	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:33875386G>C	uc010zux.1	-	4	1314	c.1196C>G	c.(1195-1197)TCA>TGA	p.S399*	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Intron	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	399										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GTTAGGGTCTGACAGTTGGCG	0.627													0	0	0	0.000602	0	4	50										C	33875386	G	C	33875386	4	2	54	1	0	0	0	0	0	1	0	0	5635	1294	45	1	1051	1	FAM83C	20	33875386	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	152809	33875386	29150134	1016	15794										
SPAG4	6676	broad.mit.edu	37	chr20	34203963	34203963	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccgggctcggcctcgtcctCgcgcaagcacacgcccaact	10	20	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:34203963C>G	uc002xdb.1	+	1	155	c.38C>G	c.(37-39)TCG>TGG	p.S13W	SPAG4_uc010zvi.1_5'UTR	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	13					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GCCTCGTCCTCGCGCAAGCAC	0.677													0	0	0	0.010729	0	9	85										G	34203963	C	G	34203963	3	3	54	1	0	0	0	0	1	0	0	0	14980	893	31	1	40	1	SPAG4	20	34203963	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	328577	34203963	28821557	1017	15795										
CPNE1	8904	broad.mit.edu	37	chr20	34220496	34220496	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcatccctcagctctggcgtCttgttgtctatgtcatagat	8	11	6	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:34220496C>A	uc002xdf.2	-	5	615	c.252G>T	c.(250-252)AAG>AAT	p.K84N	CPNE1_uc002xdc.2_5'Flank|CPNE1_uc010zvj.1_Missense_Mutation_p.K89N|CPNE1_uc002xde.2_Missense_Mutation_p.K84N|CPNE1_uc002xdg.2_Missense_Mutation_p.K84N|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.K84N|CPNE1_uc002xdi.2_Missense_Mutation_p.K84N|CPNE1_uc002xdj.2_Missense_Mutation_p.K84N|CPNE1_uc002xdk.2_Missense_Mutation_p.K84N|CPNE1_uc002xdl.2_Missense_Mutation_p.K84N|CPNE1_uc002xdm.2_Missense_Mutation_p.K84N|CPNE1_uc010gfk.1_Missense_Mutation_p.K84N|CPNE1_uc002xdn.1_RNA|CPNE1_uc002xdo.1_RNA|CPNE1_uc002xdp.1_RNA	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	84	C2 1.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GCTCTGGCGTCTTGTTGTCTA	0.512													1	0	2.47316e-13	0.003271	2.63804e-13	26	188										A	34220496	C	A	34220496	3	1	54	1	0	0	0	0	1	0	0	0	3811	912	32	3	1417	3	CPNE1	20	34220496	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	16533	34220496	28805024	1018	15796										
PHF20	51230	broad.mit.edu	37	chr20	34459608	34459608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttggaagctggccaggtctCatctgcactgacttgccact	10	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:34459608C>T	uc002xek.1	+	9	1250	c.1139C>T	c.(1138-1140)TCA>TTA	p.S380L	PHF20_uc002xei.1_Missense_Mutation_p.S380L|PHF20_uc010gfo.1_Missense_Mutation_p.S380L|PHF20_uc002xej.1_Missense_Mutation_p.S264L	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					GGCCAGGTCTCATCTGCACTG	0.458													0	0	0	0.00623	0	31	209										T	34459608	C	T	34459608	3	4	54	1	0	0	0	0	1	0	0	0	11831	838	29	1	1169	1	PHF20	20	34459608	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	239112	34459608	28565912	1019	15797										
RPRD1B	58490	broad.mit.edu	37	chr20	36662405	36662405	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctctcggagctgagcaactCtcagcagagcgtgcagaccc	12	14	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:36662405C>G	uc002xho.3	+	1	458	c.56C>G	c.(55-57)TCT>TGT	p.S19C	KIAA0406_uc002xhl.2_5'Flank|KIAA0406_uc002xhm.2_5'Flank	NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	19	CID.									pancreas(1)	1						CTGAGCAACTCTCAGCAGAGC	0.657													0	0	0	0.003954	0	25	160										G	36662405	C	G	36662405	3	3	54	1	0	0	0	0	1	0	0	0	13616	913	32	1	58	1	RPRD1B	20	36662405	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2202797	36662405	26363115	1020	15798										
SLC32A1	140679	broad.mit.edu	37	chr20	37353686	37353686	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accaggtgggaggtggtggcGaattcgggggccacgacaag	19	8	0	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:37353686G>A	uc002xjc.2	+	1	582	c.319G>A	c.(319-321)GAA>AAA	p.E107K		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	107	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	AGGTGGTGGCGAATTCGGGGG	0.652													0	0	0	0.004656	0	18	185										A	37353686	G	A	37353686	3	1	54	1	0	0	0	0	1	0	0	0	14565	1059	37	1	321	1	SLC32A1	20	37353686	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	691281	37353686	25671834	1021	15799										
CHD6	84181	broad.mit.edu	37	chr20	40079711	40079711	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aactggttcttcgtcttcttCcccttcctccctctggggac	7	16	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:40079711C>T	uc002xka.1	-	23	3736	c.3558G>A	c.(3556-3558)GGG>GGA	p.G1186G		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1186					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TCGTCTTCTTCCCCTTCCTCC	0.517													0	0	0	0.00499	0	15	136										T	40079711	C	T	40079711	2	4	54	1	0	0	0	0	0	0	0	1	3329	842	30	1		1	CHD6	20	40079711	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2726025	40079711	22945809	1022	15800										
TTPAL	79183	broad.mit.edu	37	chr20	43113071	43113071	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cagtctgaagaaacccaggtGaatggaattgtaattcttgc	10	7	2	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:43113071G>A	uc002xmc.1	+	4	664	c.540G>A	c.(538-540)GTG>GTA	p.V180V	TTPAL_uc002xmd.1_Silent_p.V180V|TTPAL_uc010ggr.1_Intron	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	180	CRAL-TRIO.					intracellular	transporter activity			breast(1)	1						AAACCCAGGTGAATGGAATTG	0.403													0	0	0	0.001984	0	6	89										A	43113071	G	A	43113071	2	1	54	1	0	0	0	0	0	0	0	1	16734	1277	45	1		1	TTPAL	20	43113071	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3033360	43113071	19912449	1023	15801										
SERINC3	10955	broad.mit.edu	37	chr20	43132467	43132467	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttaacttacctagaatacaaGaggcagagaacaaagacaaa	7	7	0	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:43132467G>A	uc002xme.2	-	8	1178	c.1044C>T	c.(1042-1044)CTC>CTT	p.L348L	SERINC3_uc002xmf.1_Silent_p.L348L|SERINC3_uc010ggs.1_Silent_p.L341L|SERINC3_uc010zwp.1_Silent_p.L293L	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	348	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			TAGAATACAAGAGGCAGAGAA	0.378													0	0	0	0.001168	0	4	61										A	43132467	G	A	43132467	2	1	54	1	0	0	0	0	0	0	0	1	14081	929	33	1		1	SERINC3	20	43132467	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	19396	43132467	19893053	1024	15802										
STK4	6789	broad.mit.edu	37	chr20	43610474	43610474	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtctctctctctctagccctCatgtagtcaaatattatggc	6	12	5	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:43610474C>T	uc002xnb.2	+	4	340	c.250C>T	c.(250-252)CAT>TAT	p.H84Y	STK4_uc010ggx.2_Missense_Mutation_p.H84Y|STK4_uc010ggy.2_Missense_Mutation_p.H84Y|STK4_uc010ggw.1_Missense_Mutation_p.H84Y	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	84	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				CTCTAGCCCTCATGTAGTCAA	0.348													0	0	0	0.00308	0	7	43										T	43610474	C	T	43610474	3	4	54	1	0	0	0	0	1	0	0	0	15305	826	29	1	264	1	STK4	20	43610474	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	478007	43610474	19415046	1025	15803										
MATN4	8785	broad.mit.edu	37	chr20	43933126	43933126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctctggcggtcgcgcgccctCggccacactgaaggccacgt	13	17	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:43933126C>T	uc002xnn.2	-	3	572	c.385G>A	c.(385-387)GAG>AAG	p.E129K	MATN4_uc002xno.2_Missense_Mutation_p.E129K|MATN4_uc002xnp.2_Missense_Mutation_p.E129K|MATN4_uc010zwr.1_Missense_Mutation_p.E77K|MATN4_uc002xnr.1_Missense_Mutation_p.E129K|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	129	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CGCGCGCCCTCGGCCACACTG	0.711													0	0	0	0.000602	0	4	17										T	43933126	C	T	43933126	3	4	54	1	0	0	0	0	1	0	0	0	9336	893	31	1	1392	1	MATN4	20	43933126	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	322652	43933126	19092394	1026	15804										
PIGT	51604	broad.mit.edu	37	chr20	44053141	44053141	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctgcttctctgtagcccatCtgtcctcagcgcccttgtgc	8	16	4	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:44053141C>G	uc002xoh.1	+	11	1479	c.1406C>G	c.(1405-1407)TCT>TGT	p.S469C	PIGT_uc002xoj.1_Missense_Mutation_p.S402C|PIGT_uc002xok.1_Missense_Mutation_p.S434C|PIGT_uc010zwu.1_Missense_Mutation_p.S207C|PIGT_uc002xoi.1_RNA|PIGT_uc010zwv.1_Missense_Mutation_p.S207C|PIGT_uc010zww.1_Missense_Mutation_p.S413C|PIGT_uc010zwx.1_Missense_Mutation_p.S304C|PIGT_uc010zwy.1_Missense_Mutation_p.S367C|PIGT_uc010zwz.1_Missense_Mutation_p.S207C|PIGT_uc010zxa.1_Missense_Mutation_p.S307C|PIGT_uc002xol.1_Missense_Mutation_p.S258C|PIGT_uc010zxb.1_Missense_Mutation_p.S145C|PIGT_uc002xom.1_Missense_Mutation_p.S61C	NM_015937	NP_057021	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	469	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				TGTAGCCCATCTGTCCTCAGC	0.582													0	0	0	0.00632	0	23	136										G	44053141	C	G	44053141	3	3	54	1	0	0	0	0	1	0	0	0	11899	913	32	1	1448	1	PIGT	20	44053141	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	120015	44053141	18972379	1027	15805										
SLC12A5	57468	broad.mit.edu	37	chr20	44671954	44671954	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggttggcatctacttcccctCagtcacaggtgaaggggagc	13	11	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:44671954C>T	uc010zxl.1	+	9	1374	c.1298C>T	c.(1297-1299)TCA>TTA	p.S433L	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.S410L	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	433	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TACTTCCCCTCAGTCACAGGT	0.517													0	0	0	0.00361	0	43	385										T	44671954	C	T	44671954	3	4	54	1	0	0	0	0	1	0	0	0	14386	838	29	1	1388	1	SLC12A5	20	44671954	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	618813	44671954	18353566	1028	15806										
SLC12A5	57468	broad.mit.edu	37	chr20	44682304	44682304	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agaaggatctgaccacatttCtgtatcatttacgcatcact	6	10	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:44682304C>G	uc010zxl.1	+	20	2780	c.2704C>G	c.(2704-2706)CTG>GTG	p.L902V	SLC12A5_uc002xrb.2_Missense_Mutation_p.L879V	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	902	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GACCACATTTCTGTATCATTT	0.552													0	0	0	0.008361	0	24	267										G	44682304	C	G	44682304	3	3	54	1	0	0	0	0	1	0	0	0	14386	912	32	1	2838	1	SLC12A5	20	44682304	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	10350	44682304	18343216	1029	15807										
ELMO2	63916	broad.mit.edu	37	chr20	45012097	45012097	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcagaaaaagtgcattaatCagtgcaatggcgtaggtctg	11	6	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:45012097C>T	uc002xrt.1	-	10	924	c.714G>A	c.(712-714)CTG>CTA	p.L238L	ELMO2_uc002xrs.1_5'Flank|ELMO2_uc002xru.1_Silent_p.L238L|ELMO2_uc010zxr.1_Silent_p.L238L|ELMO2_uc010zxs.1_Silent_p.L55L|ELMO2_uc002xrw.2_Silent_p.L55L|ELMO2_uc002xrx.1_Silent_p.L238L	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	238					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GTGCATTAATCAGTGCAATGG	0.458													0	0	0	0.001368	0	10	104										T	45012097	C	T	45012097	2	4	54	1	0	0	0	0	0	0	0	1	5066	813	29	1		1	ELMO2	20	45012097	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	329793	45012097	18013423	1030	15808										
ARFGEF2	10564	broad.mit.edu	37	chr20	47641868	47641868	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcaagacacgctggatgcaGatatccacatagagacggag	12	9	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:47641868G>C	uc002xtx.3	+	36	4926	c.4774G>C	c.(4774-4776)GAT>CAT	p.D1592H	ARFGEF2_uc010zyf.1_Missense_Mutation_p.D885H	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1592					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GCTGGATGCAGATATCCACAT	0.478													0	0	0	0.009096	0	3	22										C	47641868	G	C	47641868	3	2	54	1	0	0	0	0	1	0	0	0	853	942	33	1	4916	1	ARFGEF2	20	47641868	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2629771	47641868	15383652	1031	15809										
RNF114	55905	broad.mit.edu	37	chr20	48562721	48562721	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgtccttactgtcctgagaaGaactttgatcaggaaggact	10	8	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:48562721G>A	uc002xux.2	+	4	483	c.447G>A	c.(445-447)AAG>AAA	p.K149K	RNF114_uc010zyo.1_Silent_p.K149K|RNF114_uc002xuy.2_RNA	NM_018683	NP_061153	Q9Y508	RN114_HUMAN	zinc finger protein 313	149					cell differentiation|multicellular organismal development|spermatogenesis	intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTCCTGAGAAGAACTTTGATC	0.368													0	0	0	0.010729	0	6	69										A	48562721	G	A	48562721	2	1	54	1	0	0	0	0	0	0	0	1	13429	933	33	1		1	RNF114	20	48562721	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	920853	48562721	14462799	1032	15810										
NFATC2	4773	broad.mit.edu	37	chr20	50051746	50051746	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgggtggtaggtaaagtgctGaggctgacttcgttttctct	14	6	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:50051746G>A	uc002xwd.2	-	8	2231	c.2011C>T	c.(2011-2013)CAG>TAG	p.Q671*	NFATC2_uc002xwc.2_Nonsense_Mutation_p.Q671*|NFATC2_uc010zyv.1_Nonsense_Mutation_p.Q452*|NFATC2_uc010zyw.1_Nonsense_Mutation_p.Q452*|NFATC2_uc010zyx.1_Nonsense_Mutation_p.Q651*|NFATC2_uc010zyy.1_Nonsense_Mutation_p.Q452*|NFATC2_uc010zyz.1_Nonsense_Mutation_p.Q452*|NFATC2_uc002xwe.2_Nonsense_Mutation_p.Q651*	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	671					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GTAAAGTGCTGAGGCTGACTT	0.338													0	0	0	0.004656	0	18	175										A	50051746	G	A	50051746	4	1	54	1	0	0	0	0	0	1	0	0	10362	1299	45	1	826	1	NFATC2	20	50051746	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1489025	50051746	12973774	1033	15811										
TSHZ2	128553	broad.mit.edu	37	chr20	51873094	51873094	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agtttgtaacagacgtggatGaagaatagctctgcaggtat	12	5	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:51873094G>C	uc002xwo.2	+	2	4053	c.3097G>C	c.(3097-3099)GAA>CAA	p.E1033Q		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	1033					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGACGTGGATGAAGAATAGCT	0.493													0	0	0	0.004656	0	20	249										C	51873094	G	C	51873094	3	2	54	1	0	0	0	0	1	0	0	0	16621	1291	45	1	3103	1	TSHZ2	20	51873094	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1821348	51873094	11152426	1034	15812										
CASS4	57091	broad.mit.edu	37	chr20	55033555	55033555	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agcccgcggagatcatcactCagagcaagctggtcatcatg	11	12	5	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:55033555C>T	uc002xxp.2	+	7	2338	c.2113C>T	c.(2113-2115)CAG>TAG	p.Q705*	CASS4_uc002xxr.2_Nonsense_Mutation_p.Q705*|CASS4_uc010zze.1_Nonsense_Mutation_p.Q651*|CASS4_uc010gio.2_Nonsense_Mutation_p.Q268*	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	705					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						GATCATCACTCAGAGCAAGCT	0.597													0	0	0	0.010818	0	27	210										T	55033555	C	T	55033555	4	4	54	1	0	0	0	0	0	1	0	0	2683	827	29	1	2135	1	CASS4	20	55033555	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3160461	55033555	7991965	1035	15813										
RAE1	8480	broad.mit.edu	37	chr20	55949817	55949817	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgctgtttcaatcacaatgGaaacatatttgcatacgctt	6	8	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:55949817G>A	uc002xyg.2	+	11	1321	c.980G>A	c.(979-981)GGA>GAA	p.G327E	RAE1_uc010gis.1_Missense_Mutation_p.G280E|RAE1_uc010git.1_Missense_Mutation_p.G327E|RAE1_uc002xyh.2_Missense_Mutation_p.G327E|RAE1_uc002xyi.2_Missense_Mutation_p.G327E	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	327					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			AATCACAATGGAAACATATTT	0.433													0	0	0	0.001168	0	5	95										A	55949817	G	A	55949817	3	1	54	1	0	0	0	0	1	0	0	0	12998	1174	41	1	1018	1	RAE1	20	55949817	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	916262	55949817	7075703	1036	15814										
GNAS	2778	broad.mit.edu	37	chr20	57429312	57429312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catggacagccccccaatcgCgcttgacggcccgcccatca	9	19	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:57429312C>T	uc002xzw.2	+	1	1277	c.992C>T	c.(991-993)GCG>GTG	p.A331V	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CCCCCAATCGCGCTTGACGGC	0.647			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	0.004482	0	6	47										T	57429312	C	T	57429312	3	4	54	1	0	0	0	0	1	0	0	0	6510	768	27	2	1736	2	GNAS	20	57429312	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1479495	57429312	5596208	1037	15815										
CDH4	1002	broad.mit.edu	37	chr20	60448856	60448856	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caacgggatggtgcggtaccGgatcgtgacccagaccccac	13	14	0	2	rs147810745	by1000genomes	TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:60448856G>A	uc002ybn.1	+	7	964	c.950G>A	c.(949-951)CGG>CAG	p.R317Q	CDH4_uc002ybp.1_Missense_Mutation_p.R243Q	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	317	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTGCGGTACCGGATCGTGACC	0.612													0	0	0	0.003755	0	31	295										A	60448856	G	A	60448856	3	1	54	1	0	0	0	0	1	0	0	0	3112	1116	39	2	976	2	CDH4	20	60448856	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3019544	60448856	2576664	1038	15816										
GTPBP5	26164	broad.mit.edu	37	chr20	60768599	60768599	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgccacagcgggcttctccCaggctgctctcggtcggccg	13	17	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:60768599C>T	uc002yce.3	+	2	161	c.123C>T	c.(121-123)CCC>CCT	p.P41P	GTPBP5_uc011aab.1_Intron|GTPBP5_uc011aac.1_Intron|GTPBP5_uc011aad.1_5'UTR|GTPBP5_uc011aae.1_Intron|GTPBP5_uc011aaf.1_Silent_p.P41P|GTPBP5_uc011aag.1_Silent_p.P41P	NM_015666	NP_056481	Q9H4K7	GTPB5_HUMAN	GTP binding protein 5	41	Localized in the mitocondria.|Not localized in the mitocondria.				ribosome biogenesis	mitochondrion	GTP binding|GTPase activity|magnesium ion binding				0	Breast(26;3.52e-09)		BRCA - Breast invasive adenocarcinoma(19;2.5e-08)			GGGCTTCTCCCAGGCTGCTCT	0.617													0	0	0	0.001368	0	12	81										T	60768599	C	T	60768599	2	4	54	1	0	0	0	0	0	0	0	1	6883	581	21	2		2	GTPBP5	20	60768599	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	319743	60768599	2256921	1039	15817										
SLCO4A1	28231	broad.mit.edu	37	chr20	61300307	61300307	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcccggggcccatcgccttCggctgggtgatcgacaaggc	14	14	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:61300307C>T	uc002ydb.1	+	11	2107	c.1902C>T	c.(1900-1902)TTC>TTT	p.F634F	SLCO4A1_uc002ydc.1_RNA|LOC100127888_uc002ydd.2_5'Flank|SLCO4A1_uc002yde.1_Silent_p.F36F	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	634	Helical; Name=11; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CCATCGCCTTCGGCTGGGTGA	0.657											OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	9	83										T	61300307	C	T	61300307	2	4	54	1	0	0	0	0	0	0	0	1	14729	883	31	1		1	SLCO4A1	20	61300307	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	531708	61300307	1725213	1040	15818										
SLCO4A1	28231	broad.mit.edu	37	chr20	61303163	61303163	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caagcccctgtcggagtcttCagatggcctggaaacttgtc	11	12	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:61303163C>T	uc002ydb.1	+	12	2292	c.2087C>T	c.(2086-2088)TCA>TTA	p.S696L	SLCO4A1_uc002ydc.1_Intron|SLCO4A1_uc002yde.1_Missense_Mutation_p.S98L	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	696	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TCGGAGTCTTCAGATGGCCTG	0.632													0	0	0	0.00499	0	17	118										T	61303163	C	T	61303163	3	4	54	1	0	0	0	0	1	0	0	0	14729	838	29	1	2129	1	SLCO4A1	20	61303163	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2856	61303163	1722357	1041	15819										
DIDO1	11083	broad.mit.edu	37	chr20	61512150	61512150	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgtggctctctgtccccctCtgtttcacctgcagggctgc	10	16	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:61512150C>T	uc002ydr.1	-	16	5422	c.5158G>A	c.(5158-5160)GAG>AAG	p.E1720K	DIDO1_uc002yds.1_Missense_Mutation_p.E1720K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1720					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTGTCCCCCTCTGTTTCACCT	0.647													0	0	0	0.007291	0	20	241										T	61512150	C	T	61512150	3	4	54	1	0	0	0	0	1	0	0	0	4522	922	32	1	1568	1	DIDO1	20	61512150	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	208987	61512150	1513370	1042	15820										
RTEL1	51750	broad.mit.edu	37	chr20	62324221	62324221	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcatggtggccgtgaagcagGagttgagccaagccaacttt	13	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:62324221G>C	uc002yfu.1	+	29	3059	c.2716G>C	c.(2716-2718)GAG>CAG	p.E906Q	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.E906Q|RTEL1_uc011abd.1_Missense_Mutation_p.E930Q|RTEL1_uc011abe.1_Missense_Mutation_p.E683Q|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.E151Q|TNFRSF6B_uc002yfy.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	906					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CGTGAAGCAGGAGTTGAGCCA	0.652													0	0	0	0.007413	0	18	193										C	62324221	G	C	62324221	3	2	54	1	0	0	0	0	1	0	0	0	13720	1175	41	1	2826	1	RTEL1	20	62324221	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	812071	62324221	701299	1043	15821										
ZBTB46	140685	broad.mit.edu	37	chr20	62421337	62421337	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tgccaggcatcaccagcactCtgctctgagaaagagttctg	10	12	4	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:62421337C>T	uc002ygv.1	-	2	975	c.774G>A	c.(772-774)CAG>CAA	p.Q258Q	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CACCAGCACTCTGCTCTGAGA	0.577													0	0	0	0.00245	0	11	85										T	62421337	C	T	62421337	2	4	54	1	0	0	0	0	0	0	0	1	17544	912	32	1		1	ZBTB46	20	62421337	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	97116	62421337	604183	1044	15822										
SOX18	54345	broad.mit.edu	37	chr20	62680557	62680557	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgcaggtccgggttctgctGagccagccgcttgcgctcgt	15	13	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:62680557G>C	uc002yhs.2	-	1	423	c.313C>G	c.(313-315)CAG>GAG	p.Q105E		NM_018419	NP_060889	P35713	SOX18_HUMAN	SRY-box 18	105	HMG box.				angiogenesis|blood vessel endothelial cell migration|endocardial cell differentiation|endocardium formation|establishment of endothelial barrier|heart looping|lymphangiogenesis|lymphatic endothelial cell differentiation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|positive regulation of transcription from RNA polymerase II promoter|vasculogenesis	nucleus	transcription regulatory region DNA binding				0	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GGGTTCTGCTGAGCCAGCCGC	0.493													0	0	0	0.006122	0	13	148										C	62680557	G	C	62680557	3	2	54	1	0	0	0	0	1	0	0	0	14948	1299	45	1	849	1	SOX18	20	62680557	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	259220	62680557	344963	1045	15823										
PCMTD2	55251	broad.mit.edu	37	chr20	62891502	62891502	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catggaagcatggaaacattCacctctcagccccgtgcatc	8	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr20:62891502C>G	uc002yil.3	+	2	384	c.184C>G	c.(184-186)CAC>GAC	p.H62D	PCMTD2_uc002yim.3_Missense_Mutation_p.H62D	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	62						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TGGAAACATTCACCTCTCAGC	0.483													0	0	0	0.001368	0	12	107										G	62891502	C	G	62891502	3	3	54	1	0	0	0	0	1	0	0	0	11587	826	29	1	186	1	PCMTD2	20	62891502	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	210945	62891502	134018	1046	15824										
N6AMT1	29104	broad.mit.edu	37	chr21	30257552	30257552	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accctgccagttcggcagccGctgcctccagcgcgttcaaa	10	17	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:30257552G>A	uc002ymo.1	-	1	142	c.116C>T	c.(115-117)GCG>GTG	p.A39V	N6AMT1_uc002ymp.1_Missense_Mutation_p.A39V|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	39					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						TTCGGCAGCCGCTGCCTCCAG	0.667													0	0	0	0.011902	0	16	266										A	30257552	G	A	30257552	3	1	54	1	0	0	0	0	1	0	0	0	10114	1087	38	2	552	2	N6AMT1	21	30257552	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		30257552	17872343	1047	15825										
SFRS15	57466	broad.mit.edu	37	chr21	33057990	33057990	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtattcccagaggaggcgtGaaagcaggcggctggagagc	18	8	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:33057990G>C	uc002ypd.2	-	17	2526	c.2100C>G	c.(2098-2100)TTC>TTG	p.F700L	SFRS15_uc002ype.2_Missense_Mutation_p.F700L|SFRS15_uc010glu.2_Missense_Mutation_p.F685L|SFRS15_uc002ypf.1_Missense_Mutation_p.F374L	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	700						nucleus	nucleotide binding|RNA binding				0						GAGGAGGCGTGAAAGCAGGCG	0.537													0	0	0	0.004007	0	13	93										C	33057990	G	C	33057990	3	2	54	1	0	0	0	0	1	0	0	0	14171	1281	45	1	1359	1	SFRS15	21	33057990	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2800438	33057990	15071905	1048	15826										
IL10RB	3588	broad.mit.edu	37	chr21	34655402	34655402	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttgtctccattactagtttCaaattactccccagtatgac	4	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:34655402C>G	uc002yrk.1	+	5	601	c.502C>G	c.(502-504)CAA>GAA	p.Q168E	IL10RB_uc002yrh.1_Missense_Mutation_p.Q238E|IL10RB_uc002yri.1_Missense_Mutation_p.Q121E|IL10RB_uc002yrl.1_Missense_Mutation_p.Q170E	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	168	Fibronectin type-III.|Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						TTACTAGTTTCAAATTACTCC	0.398													0	0	0	0.00308	0	7	52										G	34655402	C	G	34655402	3	3	54	1	0	0	0	0	1	0	0	0	7621	827	29	1	520	1	IL10RB	21	34655402	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1597412	34655402	13474493	1049	15827										
DOPEY2	9980	broad.mit.edu	37	chr21	37617864	37617864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgagtcgttctccagcgacGaggaggcggacttggagctc	15	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:37617864G>A	uc002yvg.2	+	19	3665	c.3586G>A	c.(3586-3588)GAG>AAG	p.E1196K	DOPEY2_uc011aeb.1_Missense_Mutation_p.E1145K|DOPEY2_uc002yvh.2_Missense_Mutation_p.E47K	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1196					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CTCCAGCGACGAGGAGGCGGA	0.617													0	0	0	0.007413	0	18	47										A	37617864	G	A	37617864	3	1	54	1	0	0	0	0	1	0	0	0	4708	1059	37	1	3656	1	DOPEY2	21	37617864	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2962462	37617864	10512031	1050	15828										
HLCS	3141	broad.mit.edu	37	chr21	38126565	38126565	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cattaccgccgtttggggagGatgaggtttctcagcatgtc	13	9	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:38126565G>A	uc010gnb.2	-	11	3364	c.2163C>T	c.(2161-2163)ATC>ATT	p.I721I	HLCS_uc002yvs.2_Silent_p.I721I	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	721					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GTTTGGGGAGGATGAGGTTTC	0.577													0	0	0	0.001368	0	9	66										A	38126565	G	A	38126565	2	1	54	1	0	0	0	0	0	0	0	1	7213	1164	41	1		1	HLCS	21	38126565	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	508701	38126565	10003330	1051	15829										
HLCS	3141	broad.mit.edu	37	chr21	38309074	38309074	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggtacaggtcttcgggaatgGactccctggtagcaatgacc	13	10	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:38309074G>C	uc010gnb.2	-	4	1872	c.671C>G	c.(670-672)TCC>TGC	p.S224C	HLCS_uc002yvs.2_Missense_Mutation_p.S224C|HLCS_uc010gnc.1_Missense_Mutation_p.S371C	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	224					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	TTCGGGAATGGACTCCCTGGT	0.522													0	0	0	0.003271	0	31	83										C	38309074	G	C	38309074	3	2	54	1	0	0	0	0	1	0	0	0	7213	1174	41	1	1541	1	HLCS	21	38309074	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	182509	38309074	9820821	1052	15830										
TTC3	7267	broad.mit.edu	37	chr21	38461129	38461129	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcttctgagataaatttgaaGaaactacaacatcttgagtt	7	6	2	4			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:38461129G>A	uc002yvz.2	+	5	474	c.369G>A	c.(367-369)AAG>AAA	p.K123K	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Silent_p.K123K|TTC3_uc002ywb.2_Silent_p.K123K|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Silent_p.K123K	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	123					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TAAATTTGAAGAAACTACAAC	0.323													0	0	0	0.004482	0	7	36										A	38461129	G	A	38461129	2	1	54	1	0	0	0	0	0	0	0	1	16694	933	33	1		1	TTC3	21	38461129	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	152055	38461129	9668766	1053	15831										
DSCAM	1826	broad.mit.edu	37	chr21	41457556	41457556	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgtaagtttaaaataatttCatcagatccccagttgttat	5	6	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:41457556C>T	uc002yyq.1	-	23	4557	c.4105G>A	c.(4105-4107)GAA>AAA	p.E1369K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1369	Extracellular (Potential).|Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AAAATAATTTCATCAGATCCC	0.378													0	0	0	0.010504	0	15	68										T	41457556	C	T	41457556	3	4	54	1	0	0	0	0	1	0	0	0	4768	835	29	1	1977	1	DSCAM	21	41457556	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2996427	41457556	6672339	1054	15832										
UMODL1	89766	broad.mit.edu	37	chr21	43557560	43557560	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctccccgaggtgagcctcctCatgcagaagcaggcctgggt	13	14	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:43557560C>A	uc002zaf.1	+	22	3787	c.3787C>A	c.(3787-3789)CAT>AAT	p.H1263N	UMODL1_uc002zad.1_Missense_Mutation_p.H1191N|UMODL1_uc002zae.1_Missense_Mutation_p.H1319N|UMODL1_uc002zag.1_Missense_Mutation_p.H1391N|UMODL1_uc002zal.1_Missense_Mutation_p.H213N|UMODL1_uc010gpa.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	1263	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TGAGCCTCCTCATGCAGAAGC	0.607													1	0	1.59361e-14	0.006999	1.70546e-14	33	277										A	43557560	C	A	43557560	3	1	54	1	0	0	0	0	1	0	0	0	16977	826	29	3	4253	3	UMODL1	21	43557560	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2100004	43557560	4572335	1055	15833										
ABCG1	9619	broad.mit.edu	37	chr21	43704787	43704787	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccaaactcttcgagctgttCgaccaggtacgcgggccccg	12	15	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:43704787C>T	uc002zaq.2	+	7	958	c.852C>T	c.(850-852)TTC>TTT	p.F284F	ABCG1_uc002zan.2_Silent_p.F286F|ABCG1_uc002zam.2_Silent_p.F262F|ABCG1_uc002zao.2_Silent_p.F281F|ABCG1_uc002zap.2_Silent_p.F284F|ABCG1_uc002zar.2_Silent_p.F295F|ABCG1_uc011aev.1_Silent_p.F295F|ABCG1_uc010gpb.1_5'Flank	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	284	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	TCGAGCTGTTCGACCAGGTAC	0.612													0	0	0	0.00361	0	42	221										T	43704787	C	T	43704787	2	4	54	1	0	0	0	0	0	0	0	1	68	883	31	1		1	ABCG1	21	43704787	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	147227	43704787	4425108	1056	15834										
NDUFV3	4731	broad.mit.edu	37	chr21	44329053	44329053	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	catgactacagcacgtacacCttcttagacctcaacctcga	5	15	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:44329053C>G	uc002zcn.2	+	3	315	c.249C>G	c.(247-249)ACC>ACG	p.T83T	NDUFV3_uc002zcm.2_Silent_p.T448T	NM_001001503	NP_001001503	P56181	NDUV3_HUMAN	NADH-ubiquinone oxidoreductase flavoprotein 3	83					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			ovary(2)	2				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	GCACGTACACCTTCTTAGACC	0.557													0	0	0	0.009535	0	28	360										G	44329053	C	G	44329053	2	3	54	1	0	0	0	0	0	0	0	1	10301	668	24	4		4	NDUFV3	21	44329053	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	624266	44329053	3800842	1057	15835										
RRP1B	23076	broad.mit.edu	37	chr21	45096216	45096216	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaattgctgcgaagacgaagGagtaagtgattcccctgttc	11	8	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:45096216G>T	uc002zdk.2	+	7	727	c.613G>T	c.(613-615)GAC>TAC	p.D205Y		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	205					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		GAAGACGAAGGAGTAAGTGAT	0.473													1	0	1.67942e-08	0.006122	1.77097e-08	12	121										T	45096216	G	T	45096216	3	4	54	1	0	0	0	0	1	0	0	0	13688	1188	41	3	639	3	RRP1B	21	45096216	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	767163	45096216	3033679	1058	15836										
RRP1B	23076	broad.mit.edu	37	chr21	45096684	45096684	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atcagtctccttttgtgcctGaagagacgatggaggaacag	12	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:45096684G>A	uc002zdk.2	+	8	799	c.685G>A	c.(685-687)GAA>AAA	p.E229K		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	229					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		TTTTGTGCCTGAAGAGACGAT	0.502													0	0	0	0.008291	0	8	95										A	45096684	G	A	45096684	3	1	54	1	0	0	0	0	1	0	0	0	13688	1291	45	1	715	1	RRP1B	21	45096684	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	468	45096684	3033211	1059	15837										
RRP1B	23076	broad.mit.edu	37	chr21	45096750	45096750	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tctctgctgaggagatacctGaaaatgaggtatccttgaga	11	7	1	5			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:45096750G>C	uc002zdk.2	+	8	865	c.751G>C	c.(751-753)GAA>CAA	p.E251Q		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	251					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		GGAGATACCTGAAAATGAGGT	0.453													0	0	0	0.00308	0	7	89										C	45096750	G	C	45096750	3	2	54	1	0	0	0	0	1	0	0	0	13688	1291	45	1	781	1	RRP1B	21	45096750	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	66	45096750	3033145	1060	15838										
ITGB2	3689	broad.mit.edu	37	chr21	46321536	46321536	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtcagcttcagcacgtgcctGaaggcaaacgggggctggca	15	11	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:46321536G>A	uc002zgd.2	-	5	656	c.612C>T	c.(610-612)TTC>TTT	p.F204F	ITGB2_uc002zge.2_Silent_p.F204F|ITGB2_uc002zgf.3_Silent_p.F204F|ITGB2_uc011afl.1_Silent_p.F126F|ITGB2_uc010gpw.2_Silent_p.F147F|ITGB2_uc002zgg.2_Silent_p.F204F	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	204	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCACGTGCCTGAAGGCAAACG	0.587													0	0	0	0.012319	0	18	181										A	46321536	G	A	46321536	2	1	54	1	0	0	0	0	0	0	0	1	7894	1281	45	1		1	ITGB2	21	46321536	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1224786	46321536	1808359	1061	15839										
COL18A1	80781	broad.mit.edu	37	chr21	46898256	46898256	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cccagggcgaccccggtgaaGacggaaagccggtgagtctg	16	12	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr21:46898256G>A	uc011afs.1	+	8	2503	c.2482G>A	c.(2482-2484)GAC>AAC	p.D828N	COL18A1_uc002zhg.2_Missense_Mutation_p.D413N|COL18A1_uc002zhi.2_Missense_Mutation_p.D593N	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	828	Triple-helical region 2 (COL2).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CCCCGGTGAAGACGGAAAGCC	0.527											OREG0026262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	73										A	46898256	G	A	46898256	3	1	54	1	0	0	0	0	1	0	0	0	3675	942	33	1	2626	1	COL18A1	21	46898256	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	576720	46898256	1231639	1062	15840										
BCL2L13	23786	broad.mit.edu	37	chr22	18209803	18209803	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggtgcccgagggcatggaaGaggctgctgtggcttctgtg	18	8	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:18209803G>A	uc002zmw.2	+	7	1179	c.961G>A	c.(961-963)GAG>AAG	p.E321K	BCL2L13_uc002zmx.2_Missense_Mutation_p.E159K|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Missense_Mutation_p.E159K|BCL2L13_uc011agk.1_Missense_Mutation_p.E197K|BCL2L13_uc010gqz.2_Missense_Mutation_p.E41K|BCL2L13_uc002zmz.2_Missense_Mutation_p.E159K|BCL2L13_uc002zna.2_Missense_Mutation_p.E41K	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	321	Glu-rich.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		GGGCATGGAAGAGGCTGCTGT	0.557													0	0	0	0.00308	0	5	36										A	18209803	G	A	18209803	3	1	54	1	0	0	0	0	1	0	0	0	1371	943	33	1	983	1	BCL2L13	22	18209803	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		18209803	33094763	1063	15841										
MICAL3	57553	broad.mit.edu	37	chr22	18324667	18324667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgagtctcctccggtacctCctgcagtgcctcagcctgcc	9	18	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:18324667C>T	uc002zng.3	-	20	3075	c.2722G>A	c.(2722-2724)GAG>AAG	p.E908K	MICAL3_uc011agl.1_Missense_Mutation_p.E908K|MICAL3_uc002znh.2_Missense_Mutation_p.E908K|MICAL3_uc002znj.1_Missense_Mutation_p.E636K|MICAL3_uc002znk.1_Missense_Mutation_p.E908K|MICAL3_uc002znl.1_Missense_Mutation_p.E541K	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	908	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)		TCCGGTACCTCCTGCAGTGCC	0.682													0	0	0	0.009096	0	3	15										T	18324667	C	T	18324667	3	4	54	1	0	0	0	0	1	0	0	0	9571	864	30	1	3442	1	MICAL3	22	18324667	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	114864	18324667	32979899	1064	15842										
TRMT2A	27037	broad.mit.edu	37	chr22	20102529	20102529	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggccatggcctggtggcggcGgctggtgcgcacagtcagct	18	12	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:20102529G>A	uc002zrk.1	-	6	1179	c.964C>T	c.(964-966)CGC>TGC	p.R322C	TRMT2A_uc002zrl.1_Missense_Mutation_p.R322C|TRMT2A_uc002zrm.1_Missense_Mutation_p.R144C|TRMT2A_uc002zrn.1_Missense_Mutation_p.R322C|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	322					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						TGGTGGCGGCGGCTGGTGCGC	0.652													0	0	0	0.004672	0	3	21										A	20102529	G	A	20102529	3	1	54	1	0	0	0	0	1	0	0	0	16562	1116	39	2	945	2	TRMT2A	22	20102529	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1777862	20102529	31202037	1065	15843										
CRKL	1399	broad.mit.edu	37	chr22	21272303	21272303	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgccaggaggcgcagacccgGctccagggccagcgccacgg	16	17	0	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:21272303G>A	uc002ztf.2	+	1	590	c.81G>A	c.(79-81)CGG>CGA	p.R27R	CRKL_uc002ztg.1_RNA	NM_005207	NP_005198	P46109	CRKL_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	27	SH2.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity				0	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			CGCAGACCCGGCTCCAGGGCC	0.662													0	0	0	0.007413	0	15	64										A	21272303	G	A	21272303	2	1	54	1	0	0	0	0	0	0	0	1	3885	1190	42	2		2	CRKL	22	21272303	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1169774	21272303	30032263	1066	15844										
TOP3B	8940	broad.mit.edu	37	chr22	22330076	22330076	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcagcaaccatgagcacagtCttcattttgtctcggtcctt	7	12	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:22330076C>T	uc002zvs.2	-	2	441	c.6G>A	c.(4-6)AAG>AAA	p.K2K	TOP3B_uc010gtl.2_Silent_p.K2K|TOP3B_uc002zvt.3_Silent_p.K2K	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	2					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TGAGCACAGTCTTCATTTTGT	0.493													0	0	0	0.000602	0	5	45										T	22330076	C	T	22330076	2	4	54	1	0	0	0	0	0	0	0	1	16365	912	32	1		1	TOP3B	22	22330076	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1057773	22330076	28974490	1067	15845										
RTDR1	27156	broad.mit.edu	37	chr22	23482428	23482428	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctatgttcatggccttgtaGatacactcggggtcatgcat	10	10	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:23482428G>C	uc002zwt.2	-	2	338	c.180C>G	c.(178-180)ATC>ATG	p.I60M	RTDR1_uc010gtv.1_Missense_Mutation_p.I60M	NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	60							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		TGGCCTTGTAGATACACTCGG	0.557													0	0	0	0.00308	0	6	53										C	23482428	G	C	23482428	3	2	54	1	0	0	0	0	1	0	0	0	13719	932	33	1	890	1	RTDR1	22	23482428	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1152352	23482428	27822138	1068	15846										
SUSD2	56241	broad.mit.edu	37	chr22	24579478	24579478	+	Missense_Mutation	SNP	C	C	G													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacaggtttaaggacagcatCcagaccctcggccatgtgga							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:24579478C>G	uc002zzn.1	+	3	347	c.303C>G	c.(301-303)ATC>ATG	p.I101M		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	101	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						AGGACAGCATCCAGACCCTCG	0.627													0	0	0	0.007835	0	30	256										G	24579478	C	G	24579478	3	3	54	1	0	0	0	0	1	0	0	0	15405	845	30	1	313	1	SUSD2	22	24579478	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1097050	24579478	26725088	1069	15847	79	2								
SUSD2	56241	broad.mit.edu	37	chr22	24579487	24579487	+	Silent	SNP	C	C	A													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aaggacagcatccagaccctCggccatgtggactcctccgg					rs143350390	byFrequency	TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:24579487C>A	uc002zzn.1	+	3	356	c.312C>A	c.(310-312)CTC>CTA	p.L104L		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	104	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						TCCAGACCCTCGGCCATGTGG	0.627													1	0	2.52637e-11	0.005524	2.68375e-11	30	264										A	24579487	C	A	24579487	2	1	54	1	0	0	0	0	0	0	0	1	15405	871	31	3		3	SUSD2	22	24579487	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	9	24579487	26725079	1070	15848	79	2								
SUSD2	56241	broad.mit.edu	37	chr22	24581693	24581693	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggacgcagctcctgacagctGactccagcggcggcagcact	13	15	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:24581693G>A	uc002zzn.1	+	8	1179	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	379	AMOP.|Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCTGACAGCTGACTCCAGCGG	0.687													0	0	0	0.001368	0	11	40										A	24581693	G	A	24581693	3	1	54	1	0	0	0	0	1	0	0	0	15405	1290	45	1	1165	1	SUSD2	22	24581693	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2206	24581693	26722873	1071	15849										
TPST2	8459	broad.mit.edu	37	chr22	26932283	26932283	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttgttgatgacgaaggggtCagggttgccatagttggggg	19	4	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:26932283C>T	uc003acv.2	-	3	1180	c.1012G>A	c.(1012-1014)GAC>AAC	p.D338N	TPST2_uc003acw.2_Missense_Mutation_p.D338N|TPST2_uc003acx.2_Missense_Mutation_p.D338N	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	338	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						ACGAAGGGGTCAGGGTTGCCA	0.572													0	0	0	0.006214	0	7	73										T	26932283	C	T	26932283	3	4	54	1	0	0	0	0	1	0	0	0	16425	826	29	1	133	1	TPST2	22	26932283	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2350590	26932283	24372283	1072	15850										
GAS2L1	10634	broad.mit.edu	37	chr22	29706489	29706489	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcccatgatcaaggtctcaGaggggaagtaccgtgtgggg	15	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:29706489G>A	uc003afa.1	+	3	893	c.694G>A	c.(694-696)GAG>AAG	p.E232K	GAS2L1_uc010gvm.1_Missense_Mutation_p.E232K|GAS2L1_uc003afb.1_Missense_Mutation_p.E232K|GAS2L1_uc003afc.1_Missense_Mutation_p.E232K|GAS2L1_uc003afd.1_Missense_Mutation_p.E232K|GAS2L1_uc003afe.1_Missense_Mutation_p.E232K	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	232	GAR.				cell cycle arrest	cytoplasm|cytoskeleton					0						CAAGGTCTCAGAGGGGAAGTA	0.647													0	0	0	0.00333	0	19	120										A	29706489	G	A	29706489	3	1	54	1	0	0	0	0	1	0	0	0	6246	943	33	1	700	1	GAS2L1	22	29706489	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2774206	29706489	21598077	1073	15851										
AP1B1	162	broad.mit.edu	37	chr22	29737585	29737585	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tagacggaagccagcgtgccGatgtagcagataagctcgtc	13	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:29737585G>A	uc003afj.2	-	13	1885	c.1701C>T	c.(1699-1701)ATC>ATT	p.I567I	AP1B1_uc003afi.2_Silent_p.I567I|AP1B1_uc003afk.2_Silent_p.I567I|AP1B1_uc003afl.2_Silent_p.I567I|AP1B1_uc011ako.1_Silent_p.I120I	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	567					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CCAGCGTGCCGATGTAGCAGA	0.617													0	0	0	0.00278	0	17	109										A	29737585	G	A	29737585	2	1	54	1	0	0	0	0	0	0	0	1	731	1048	37	1		1	AP1B1	22	29737585	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	31096	29737585	21566981	1074	15852										
SF3A1	10291	broad.mit.edu	37	chr22	30730592	30730592	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttcctcttgtctacttcttCctcccgcctctctccttgag	5	17	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:30730592C>T	uc003ahl.2	-	16	2505	c.2373G>A	c.(2371-2373)AGG>AGA	p.R791R		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	791	Ubiquitin-like.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						TCTACTTCTTCCTCCCGCCTC	0.562													0	0	0	0.00333	0	20	158										T	30730592	C	T	30730592	2	4	54	1	0	0	0	0	0	0	0	1	14146	854	30	1		1	SF3A1	22	30730592	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	993007	30730592	20573974	1075	15853										
TCN2	6948	broad.mit.edu	37	chr22	31019015	31019015	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccgtgatggggaaagcggcCggagaaagggagttctggca	18	7	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:31019015C>T	uc003aip.1	+	8	1325	c.1167C>T	c.(1165-1167)GCC>GCT	p.A389A	TCN2_uc003aiq.1_Silent_p.A385A|TCN2_uc003air.1_Silent_p.A362A	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	389					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGAAAGCGGCCGGAGAAAGGG	0.562													0	0	0	0.010729	0	9	96										T	31019015	C	T	31019015	2	4	54	1	0	0	0	0	0	0	0	1	15704	639	23	2		2	TCN2	22	31019015	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	288423	31019015	20285551	1076	15854										
APOL4	80832	broad.mit.edu	37	chr22	36587672	36587672	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	accccagctgcagtaatgctCaggctcagccctgctgtaaa	9	14	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:36587672C>T	uc003aox.2	-	6	732	c.507G>A	c.(505-507)CTG>CTA	p.L169L	APOL4_uc003aow.2_Silent_p.L166L|APOL4_uc010gww.2_Silent_p.L11L	NM_145660	NP_663693	Q9BPW4	APOL4_HUMAN	apolipoprotein L4 isoform 2 precursor	169					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding				0						CAGTAATGCTCAGGCTCAGCC	0.562													0	0	0	0.000602	0	5	16										T	36587672	C	T	36587672	2	4	54	1	0	0	0	0	0	0	0	1	808	835	29	1		1	APOL4	22	36587672	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	5568657	36587672	14716894	1077	15855										
APOL2	23780	broad.mit.edu	37	chr22	36623580	36623580	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccccctcaagcaagtgctttGactcatatgcaaggctgacc	8	14	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:36623580G>C	uc003aoz.2	-	5	1220	c.884C>G	c.(883-885)TCA>TGA	p.S295*	APOL2_uc011amm.1_Nonsense_Mutation_p.S407*|APOL2_uc003apa.2_Nonsense_Mutation_p.S295*	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	295					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						CAAGTGCTTTGACTCATATGC	0.562													0	0	0	0.00623	0	29	171										C	36623580	G	C	36623580	4	2	54	1	0	0	0	0	0	1	0	0	806	1294	45	1	133	1	APOL2	22	36623580	Nonsense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	35908	36623580	14680986	1078	15856										
APOL2	23780	broad.mit.edu	37	chr22	36624083	36624084	+	Missense_Mutation	DNP	AG	AG	TA													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgaggagggtcaggatgccAgaggtagtgccaacagagtt							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:36624083_36624084AG>TA	uc003aoz.2	-	5	716_717	c.380_381CT>TA	c.(379-381)TCT>TTA	p.S127L	APOL2_uc011amm.1_Missense_Mutation_p.S239L|APOL2_uc003apa.2_Missense_Mutation_p.S127L	NM_030882	NP_112092	Q9BQE5	APOL2_HUMAN	apolipoprotein L2	127					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding				0						TCAGGATGCCAGAGGTAGTGCC	0.574													0	0	0	0.004672	0	14	57										TA	36624084	AG	TA	36624083	3	4	54	1	0	0	0	0	1	0	0	0	806	175	7	5	636	5	APOL2	22	36624083	Missense_Mutation	DNP	AG	TCGA-DK-A2I4-01A-11D-A21A-08	503	36624083	14680483	1079	15857										
APOL1	8542	broad.mit.edu	37	chr22	36661542	36661542	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttgggaatcacagccgctttGaccgggattaccagcagtac	11	11	1	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:36661542G>C	uc003apf.2	+	6	828	c.660G>C	c.(658-660)TTG>TTC	p.L220F	APOL1_uc011amn.1_Missense_Mutation_p.L97F|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.L236F|APOL1_uc011amo.1_Missense_Mutation_p.L97F|APOL1_uc011amp.1_Missense_Mutation_p.L220F|APOL1_uc011amq.1_Missense_Mutation_p.L202F|APOL1_uc010gwx.2_Missense_Mutation_p.L97F	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	220					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						CAGCCGCTTTGACCGGGATTA	0.557													0	0	0	0.008871	0	18	126										C	36661542	G	C	36661542	3	2	54	1	0	0	0	0	1	0	0	0	805	1281	45	1	730	1	APOL1	22	36661542	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	37459	36661542	14643024	1080	15858										
MYH9	4627	broad.mit.edu	37	chr22	36698620	36698620	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cttctagcacgcaccttggtGaagagccgccaccactgcca	9	16	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:36698620G>A	uc003apg.2	-	20	2724	c.2493C>T	c.(2491-2493)TTC>TTT	p.F831F	MYH9_uc003aph.1_Silent_p.F695F	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	831					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCACCTTGGTGAAGAGCCGCC	0.373			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.010818	0	23	127										A	36698620	G	A	36698620	2	1	54	1	0	0	0	0	0	0	0	1	10042	1281	45	1		1	MYH9	22	36698620	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	37078	36698620	14605946	1081	15859										
APOBEC3B	9582	broad.mit.edu	37	chr22	39387537	39387537	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cacgtgagactgcgcatcttCgctgcccgcatctatgatta	9	13	2	2	rs144471703		TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:39387537C>T	uc003awo.1	+	6	978	c.924C>T	c.(922-924)TTC>TTT	p.F308F	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awp.1_Silent_p.F283F|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Intron|APOBEC3D_uc011aoe.1_Intron|APOBEC3D_uc011aof.1_Intron	NM_004900	NP_004891	Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	308					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(58;0.04)					TGCGCATCTTCGCTGCCCGCA	0.572													0	0	0	0.00623	0	32	173										T	39387537	C	T	39387537	2	4	54	1	0	0	0	0	0	0	0	1	790	883	31	1		1	APOBEC3B	22	39387537	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2688917	39387537	11917029	1082	15860										
EP300	2033	broad.mit.edu	37	chr22	41560132	41560133	+	Frame_Shift_Ins	INS	-	-	G													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgagatcatctggcctgctINSgggtaagtcttaacgttgtt							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:41560132_41560133insG	uc003azl.3	+	22	4199_4200	c.3804_3805insG	c.(3802-3807)GCTGGAfs	p.A1268fs		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1268_1269					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TCTGGCCTGCTGGGTAAGTCTT	0.371			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome									20	164	---	---								G	41560133	-	G	41560132	7	5	54	1	0	1	1	0	0	0	0	0	5148	1567	55	0	3890	0	EP300	22	41560132	Frame_Shift_Ins	INS	-	TCGA-DK-A2I4-01A-11D-A21A-08	2172595	41560132	9744434	1083	15861										
EP300	2033	broad.mit.edu	37	chr22	41562613	41562613	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttacatttagattcgtctgtGatggctgtttaaagaaaagt	9	4	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:41562613G>A	uc003azl.3	+	23	4212	c.3817G>A	c.(3817-3819)GAT>AAT	p.D1273N		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1273					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATTCGTCTGTGATGGCTGTTT	0.254			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.009096	0	3	18										A	41562613	G	A	41562613	3	1	54	1	0	0	0	0	1	0	0	0	5148	1290	45	1	3907	1	EP300	22	41562613	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2481	41562613	9741953	1084	15862										
TCF20	6942	broad.mit.edu	37	chr22	42606365	42606365	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tcttcttcctcagcattgatGattgtacaaacggctccaag	7	11	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:42606365G>A	uc003bcj.1	-	1	5081	c.4947C>T	c.(4945-4947)ATC>ATT	p.I1649I	TCF20_uc003bck.1_Silent_p.I1649I|TCF20_uc003bnt.2_Silent_p.I1649I	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1649					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CAGCATTGATGATTGTACAAA	0.478													0	0	0	0.010771	0	34	146										A	42606365	G	A	42606365	2	1	54	1	0	0	0	0	0	0	0	1	15687	1280	45	1		1	TCF20	22	42606365	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1043752	42606365	8698201	1085	15863										
CELSR1	9620	broad.mit.edu	37	chr22	46930976	46930976	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctccccacggccgcatcctCattcagacgaagctcgtagg	10	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:46930976C>T	uc003bhw.1	-	1	2092	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	698	Extracellular (Potential).|Cadherin 5.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCCGCATCCTCATTCAGACGA	0.637													0	0	0	0.004482	0	8	45										T	46930976	C	T	46930976	3	4	54	1	0	0	0	0	1	0	0	0	3221	835	29	1	7092	1	CELSR1	22	46930976	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4324611	46930976	4373590	1086	15864										
SBF1	6305	broad.mit.edu	37	chr22	50893737	50893737	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgtgagctccacggtggctGaagcgatggccgaaggacag	17	9	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:50893737G>C	uc003blh.2	-	33	4665	c.4470C>G	c.(4468-4470)TTC>TTG	p.F1490L	SBF1_uc003ble.2_5'UTR|SBF1_uc003blf.2_5'UTR|SBF1_uc011arx.1_Missense_Mutation_p.F1128L	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1464	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CACGGTGGCTGAAGCGATGGC	0.642													0	0	0	0.003163	0	13	68										C	50893737	G	C	50893737	3	2	54	1	0	0	0	0	1	0	0	0	13858	1281	45	1	1247	1	SBF1	22	50893737	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	3962761	50893737	410829	1087	15865										
ADM2	79924	broad.mit.edu	37	chr22	50921131	50921131	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgttatgggtcagcctctCcgggatggtggccgccaaca	13	13	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:50921131C>T	uc003blj.2	+	2	511	c.246C>T	c.(244-246)CTC>CTT	p.L82L	ADM2_uc011ary.1_Silent_p.L82L	NM_024866	NP_079142	Q7Z4H4	ADM2_HUMAN	adrenomedullin 2 precursor	82					positive regulation of angiogenesis	extracellular region	hormone activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTCAGCCTCTCCGGGATGGTG	0.716													0	0	0	0.001984	0	6	34										T	50921131	C	T	50921131	2	4	54	1	0	0	0	0	0	0	0	1	322	842	30	1		1	ADM2	22	50921131	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	27394	50921131	383435	1088	15866										
CHKB	1120	broad.mit.edu	37	chr22	51017894	51017894	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtggacatggatgcctggagGatggaccacagaccccagaa	14	10	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chr22:51017894G>T	uc003bms.2	-	10	1292	c.1074C>A	c.(1072-1074)ATC>ATA	p.I358I	CPT1B_uc003bmk.3_5'Flank|CPT1B_uc003bml.2_5'Flank|CPT1B_uc003bmm.2_5'Flank|CPT1B_uc003bmo.2_5'Flank|CPT1B_uc011asa.1_5'Flank|CPT1B_uc003bmn.2_5'Flank|CPT1B_uc011asb.1_5'Flank|CHKB-CPT1B_uc003bmp.2_5'UTR|CHKB-CPT1B_uc003bmt.1_Silent_p.I149I|CHKB-CPT1B_uc003bmu.2_Silent_p.I237I|CHKB_uc003bmv.2_Silent_p.I358I	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	358					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	ATGCCTGGAGGATGGACCACA	0.562													1	0	7.48243e-07	0.006214	7.82034e-07	6	45										T	51017894	G	T	51017894	2	4	54	1	0	0	0	0	0	0	0	1	3348	1164	41	3		3	CHKB	22	51017894	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	96763	51017894	286672	1089	15867										
WWC3	55841	broad.mit.edu	37	chrX	10106775	10106775	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	aggtcttccctggctgagctCatggcccgcacctccctgga	11	16	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:10106775C>T	uc004csx.3	+	21	3081	c.2883C>T	c.(2881-2883)CTC>CTT	p.L961L	WWC3_uc010nds.2_Silent_p.L625L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	961										ovary(4)	4						TGGCTGAGCTCATGGCCCGCA	0.597													0	0	0	0.001984	0	6	33										T	10106775	C	T	10106775	2	4	54	1	0	0	0	0	0	0	0	1	17410	813	29	1		1	WWC3	23	10106775	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08		10106775	145163785	1090	15868										
GLRA2	2742	broad.mit.edu	37	chrX	14708969	14708969	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgcctccgaagaagacagaaGaggcagaataaggtatgatt	12	7	0	6			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:14708969G>A	uc010nep.2	+	9	1400	c.1068G>A	c.(1066-1068)AAG>AAA	p.K356K	GLRA2_uc010neq.2_Silent_p.K356K|GLRA2_uc004cwe.3_Silent_p.K356K|GLRA2_uc011mio.1_Silent_p.K267K|GLRA2_uc011mip.1_Silent_p.K334K	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	356	Cytoplasmic (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	GAAGACAGAAGAGGCAGAATA	0.468													0	0	0	0.006214	0	7	48										A	14708969	G	A	14708969	2	1	54	1	0	0	0	0	0	0	0	1	6455	933	33	1		1	GLRA2	23	14708969	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	4602194	14708969	140561591	1091	15869										
NHS	4810	broad.mit.edu	37	chrX	17749980	17749980	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tttctccttttctcaaagatCcaagaggaaagtacttggaa	7	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:17749980C>T	uc004cxx.2	+	8	4627	c.4289C>T	c.(4288-4290)TCC>TTC	p.S1430F	NHS_uc011mix.1_Missense_Mutation_p.S1451F|NHS_uc004cxy.2_Missense_Mutation_p.S1274F|NHS_uc004cxz.2_Missense_Mutation_p.S1253F|NHS_uc004cya.2_Missense_Mutation_p.S1153F	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1430						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					TCTCAAAGATCCAAGAGGAAA	0.448													0	0	0	0.010771	0	37	48										T	17749980	C	T	17749980	3	4	54	1	0	0	0	0	1	0	0	0	10411	855	30	1	4424	1	NHS	23	17749980	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	3041011	17749980	137520580	1092	15870										
PDHA1	5160	broad.mit.edu	37	chrX	19369482	19369482	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cgggctcacggctttactttCacccggggcctttccgtccg	11	16	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:19369482C>T	uc004czg.3	+	4	520	c.375C>T	c.(373-375)TTC>TTT	p.F125F	PDHA1_uc004czh.3_Silent_p.F160F|PDHA1_uc011mjc.1_Silent_p.F129F|PDHA1_uc011mjd.1_Silent_p.F122F|PDHA1_uc010nfk.2_Silent_p.F122F	NM_000284	NP_000275	P08559	ODPA_HUMAN	pyruvate dehydrogenase E1 alpha 1 precursor	125					glycolysis|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	protein binding|pyruvate dehydrogenase (acetyl-transferring) activity			ovary(1)	1	Hepatocellular(33;0.183)				NADH(DB00157)	GCTTTACTTTCACCCGGGGCC	0.502													0	0	0	0.004878	0	26	67										T	19369482	C	T	19369482	2	4	54	1	0	0	0	0	0	0	0	1	11664	825	29	1		1	PDHA1	23	19369482	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1619502	19369482	135901078	1093	15871										
DDX3X	1654	broad.mit.edu	37	chrX	41202027	41202027	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gcaacactgggattaattttGagaaatacgatgacattcca	8	7	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:41202027G>C	uc004dfe.2	+	6	1336	c.481G>C	c.(481-483)GAG>CAG	p.E161Q	DDX3X_uc010nhf.1_Missense_Mutation_p.E145Q|DDX3X_uc004dff.2_Missense_Mutation_p.E161Q|DDX3X_uc011mkq.1_Missense_Mutation_p.E145Q|DDX3X_uc011mkr.1_Missense_Mutation_p.E161Q|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	161					interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						GATTAATTTTGAGAAATACGA	0.373										HNSCC(61;0.18)			0	0	0	0.008871	0	14	55										C	41202027	G	C	41202027	3	2	54	1	0	0	0	0	1	0	0	0	4358	1291	45	1	503	1	DDX3X	23	41202027	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	21832545	41202027	114068533	1094	15872										
DDX3X	1654	broad.mit.edu	37	chrX	41203033	41203033	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctgttgcccatcttgagtcaGatttattcagatggtccagg	10	9	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:41203033G>A	uc004dfe.2	+	8	1578	c.723G>A	c.(721-723)CAG>CAA	p.Q241Q	DDX3X_uc010nhf.1_Silent_p.Q225Q|DDX3X_uc004dff.2_Silent_p.Q241Q|DDX3X_uc011mkq.1_Silent_p.Q225Q|DDX3X_uc011mkr.1_Silent_p.Q241Q|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_Intron	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	241	Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TCTTGAGTCAGATTTATTCAG	0.403										HNSCC(61;0.18)			0	0	0	0.003163	0	12	40										A	41203033	G	A	41203033	2	1	54	1	0	0	0	0	0	0	0	1	4358	933	33	1		1	DDX3X	23	41203033	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	1006	41203033	114067527	1095	15873										
PHF16	9767	broad.mit.edu	37	chrX	46913947	46913947	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ttcctccaaaggaggatgaaGaaaatgggctggtgcagcca	13	8	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:46913947G>A	uc004dgx.2	+	9	1411	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K	PHF16_uc004dgy.2_Missense_Mutation_p.E454K	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	454					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						GGAGGATGAAGAAAATGGGCT	0.458													0	0	0	0.009096	0	4	11										A	46913947	G	A	46913947	3	1	54	1	0	0	0	0	1	0	0	0	11827	943	33	1	1390	1	PHF16	23	46913947	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	5710914	46913947	108356613	1096	15874										
GATA1	2623	broad.mit.edu	37	chrX	48650256	48650256	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	acctgcccccaacagtctttCaggtgtacccattgctcaac	6	16	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:48650256C>T	uc004dkq.3	+	3	317	c.226C>T	c.(226-228)CAG>TAG	p.Q76*		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	76					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)|p.V74fs*60(1)|p.Q76E(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						AACAGTCTTTCAGGTGTACCC	0.587			Mis|F		megakaryoblastic leukemia of Downs Syndrome								0	0	0	0.006122	0	14	85										T	48650256	C	T	48650256	4	4	54	1	0	0	0	0	0	1	0	0	6253	827	29	1	232	1	GATA1	23	48650256	Nonsense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1736309	48650256	106620304	1097	15875			7	64		4	4	335	C		2.789324e-07
GATA1	2623	broad.mit.edu	37	chrX	48650377	48650377	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gtgtcccacccgcgaggactCtcctccccaggccgtggaag	12	17	1	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:48650377C>G	uc004dkq.3	+	3	438	c.347C>G	c.(346-348)TCT>TGT	p.S116C		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	116					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)|p.V77_A120>A(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						CGCGAGGACTCTCCTCCCCAG	0.627			Mis|F		megakaryoblastic leukemia of Downs Syndrome								0	0	0	0.008871	0	16	49										G	48650377	C	G	48650377	3	3	54	1	0	0	0	0	1	0	0	0	6253	913	32	1	353	1	GATA1	23	48650377	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	121	48650377	106620183	1098	15876			7	64		4	4	335	C		2.789324e-07
GATA1	2623	broad.mit.edu	37	chrX	48650546	48650546	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	cctgacttttccagtaccttCttttctcccaccgggagccc	6	17	2	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:48650546C>A	uc004dkq.3	+	3	607	c.516C>A	c.(514-516)TTC>TTA	p.F172L		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	172					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						CCAGTACCTTCTTTTCTCCCA	0.567			Mis|F		megakaryoblastic leukemia of Downs Syndrome								1	0	9.31168e-06	0.001855	9.66208e-06	12	33										A	48650546	C	A	48650546	3	1	54	1	0	0	0	0	1	0	0	0	6253	912	32	3	522	3	GATA1	23	48650546	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	169	48650546	106620014	1099	15877			7	64		4	4	335	C		2.789324e-07
GATA1	2623	broad.mit.edu	37	chrX	48650590	48650590	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	caattcagcagcctattcctCtcccaagcttcgtggaactc	6	15	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:48650590C>T	uc004dkq.3	+	3	651	c.560C>T	c.(559-561)TCT>TTT	p.S187F		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	187					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GCCTATTCCTCTCCCAAGCTT	0.542			Mis|F		megakaryoblastic leukemia of Downs Syndrome								0	0	0	0.003163	0	11	35										T	48650590	C	T	48650590	3	4	54	1	0	0	0	0	1	0	0	0	6253	913	32	1	566	1	GATA1	23	48650590	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	44	48650590	106619970	1100	15878			7	64		4	4	335	C		2.789324e-07
DGKK	139189	broad.mit.edu	37	chrX	50129585	50129585	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctatcatacattaagtcactCtatatagaaaggaaggagac	7	7	3	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:50129585C>G	uc010njr.1	-	15	2179	c.2119_splice	c.e15-1	p.S707_splice		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TTAAGTCACTCTATATAGAAA	0.483													0	0	0	0.004672	0	2	9										G	50129585	C	G	50129585	5	3	54	1	0	0	0	0	0	0	1	0	4472	927	32	1	1752	1	DGKK	23	50129585	Splice_Site	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1478995	50129585	105140975	1101	15879										
SSX7	280658	broad.mit.edu	37	chrX	52681310	52681310	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccgtctactcaccctgattcCcttggttacggtcattatca	6	14	4	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:52681310C>T	uc004dqx.1	-	4	431	c.272G>A	c.(271-273)GGG>GAG	p.G91E		NM_173358	NP_775494	Q7RTT5	SSX7_HUMAN	synovial sarcoma, X breakpoint 7	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			skin(1)	1	Ovarian(276;0.236)					ACCCTGATTCCCTTGGTTACG	0.517													0	0	0	0.002299	0	19	77										T	52681310	C	T	52681310	3	4	54	1	0	0	0	0	1	0	0	0	15208	623	22	2	310	2	SSX7	23	52681310	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2551725	52681310	102589250	1102	15880										
PFKFB1	5207	broad.mit.edu	37	chrX	54975561	54975561	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ataggggacacccagggcctCagctgtctggatggtcctct	13	12	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:54975561C>T	uc004dty.1	-	9	1011	c.940G>A	c.(940-942)GAG>AAG	p.E314K	PFKFB1_uc010nkd.1_Intron|PFKFB1_uc011mol.1_Missense_Mutation_p.E249K	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	314	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						CCCAGGGCCTCAGCTGTCTGG	0.557													0	0	0	0.00499	0	15	46										T	54975561	C	T	54975561	3	4	54	1	0	0	0	0	1	0	0	0	11760	835	29	1	499	1	PFKFB1	23	54975561	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	2294251	54975561	100294999	1103	15881										
ALAS2	212	broad.mit.edu	37	chrX	55051212	55051212	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gccttctgcacaatcttgctCttcccatcctggagttccga	7	15	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:55051212C>T	uc004dua.3	-	3	381	c.243G>A	c.(241-243)AAG>AAA	p.K81K	ALAS2_uc004dub.3_Silent_p.K105K|ALAS2_uc004dud.3_Silent_p.K81K	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	81					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CAATCTTGCTCTTCCCATCCT	0.488													0	0	0	0.004007	0	14	42										T	55051212	C	T	55051212	2	4	54	1	0	0	0	0	0	0	0	1	485	912	32	1		1	ALAS2	23	55051212	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	75651	55051212	100219348	1104	15882										
HNRNPH2	3188	broad.mit.edu	37	chrX	100667669	100667669	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ggagctgggtttgaaaggatGaggcgtggtgcctatggtgg	20	4	0	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:100667669G>A	uc004ehm.2	+	2	863	c.693G>A	c.(691-693)ATG>ATA	p.M231I	HNRNPH2_uc004ehn.2_Missense_Mutation_p.M231I	NM_019597	NP_062543	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2	231					nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TTGAAAGGATGAGGCGTGGTG	0.522													0	0	0	0.003954	0	24	58										A	100667669	G	A	100667669	3	1	54	1	0	0	0	0	1	0	0	0	7267	1290	45	1	695	1	HNRNPH2	23	100667669	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	45616457	100667669	54602891	1105	15883										
MID2	11043	broad.mit.edu	37	chrX	107169434	107169434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taaagaagagccacaccccaGagaggtttagtggcacaggg	13	9	0	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:107169434G>C	uc004enl.2	+	9	2281	c.1708G>C	c.(1708-1710)GAG>CAG	p.E570Q	MID2_uc004enk.2_Missense_Mutation_p.E540Q	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	570	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CCACACCCCAGAGAGGTTTAG	0.468													0	0	0	0.010729	0	11	30										C	107169434	G	C	107169434	3	2	54	1	0	0	0	0	1	0	0	0	9578	943	33	1	1742	1	MID2	23	107169434	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6501765	107169434	48101126	1106	15884										
TMEM164	84187	broad.mit.edu	37	chrX	109416484	109416484	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	tccctgcaggtcaccgaagtGaatttgaacaacatgctgtg	10	10	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:109416484G>A	uc004eom.2	+	7	1018	c.699G>A	c.(697-699)GTG>GTA	p.V233V	TMEM164_uc004eol.2_Silent_p.V84V|TMEM164_uc010npq.2_Silent_p.V194V|TMEM164_uc004eon.1_5'Flank	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	233						integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						TCACCGAAGTGAATTTGAACA	0.557													0	0	0	0.00632	0	23	79										A	109416484	G	A	109416484	2	1	54	1	0	0	0	0	0	0	0	1	16076	1277	45	1		1	TMEM164	23	109416484	Silent	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	2247050	109416484	45854076	1107	15885										
DCX	1641	broad.mit.edu	37	chrX	110653275	110653275	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	taaattaccttcctccagttCatccatgcttccgatcttcc	3	15	2	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:110653275C>T	uc004epd.2	-	2	767	c.595G>A	c.(595-597)GAA>AAA	p.E199K	DCX_uc011msv.1_Missense_Mutation_p.E199K|DCX_uc004epe.2_Missense_Mutation_p.E118K|DCX_uc004epf.2_Missense_Mutation_p.E118K|DCX_uc004epg.2_Missense_Mutation_p.E118K	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	199	Doublecortin 1.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TCCTCCAGTTCATCCATGCTT	0.468													0	0	0	0.003163	0	13	50										T	110653275	C	T	110653275	3	4	54	1	0	0	0	0	1	0	0	0	4318	835	29	1	769	1	DCX	23	110653275	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	1236791	110653275	44617285	1108	15886										
GPC4	2239	broad.mit.edu	37	chrX	132440162	132440162	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gaaaggaccctctagcctctCtgccaccatcagcatagcat	7	15	3	0			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:132440162C>G	uc004exc.1	-	5	1110	c.898G>C	c.(898-900)GAG>CAG	p.E300Q	GPC4_uc011mvg.1_Missense_Mutation_p.E230Q	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	300					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					TCTAGCCTCTCTGCCACCATC	0.393													0	0	0	0.006122	0	17	82										G	132440162	C	G	132440162	3	3	54	1	0	0	0	0	1	0	0	0	6600	922	32	1	792	1	GPC4	23	132440162	Missense_Mutation	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	21786887	132440162	22830398	1109	15887										
MAGEC2	51438	broad.mit.edu	37	chrX	141291072	141291072	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ccctttatgaagatcacactCagaataataatcaggaggct	7	9	3	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:141291072C>T	uc004fbu.1	-	3	1050	c.702G>A	c.(700-702)CTG>CTA	p.L234L		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	234	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGATCACACTCAGAATAATAA	0.512										HNSCC(46;0.14)			0	0	0	0.010504	0	16	94										T	141291072	C	T	141291072	2	4	54	1	0	0	0	0	0	0	0	1	9181	813	29	1		1	MAGEC2	23	141291072	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	8850910	141291072	13979488	1110	15888										
AFF2	2334	broad.mit.edu	37	chrX	148037319	148037319	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	atgccagtcaggtcccagctGaacccaaagaaaggcctctc	9	14	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:148037319G>A	uc004fcp.2	+	11	2223	c.1744G>A	c.(1744-1746)GAA>AAA	p.E582K	AFF2_uc004fcq.2_Missense_Mutation_p.E572K|AFF2_uc004fcr.2_Missense_Mutation_p.E543K|AFF2_uc011mxb.1_Missense_Mutation_p.E547K|AFF2_uc004fcs.2_Missense_Mutation_p.E549K|AFF2_uc011mxc.1_Missense_Mutation_p.E223K	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	582					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GGTCCCAGCTGAACCCAAAGA	0.478													0	0	0	0.012319	0	19	74										A	148037319	G	A	148037319	3	1	54	1	0	0	0	0	1	0	0	0	357	1291	45	1	1841	1	AFF2	23	148037319	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	6746247	148037319	7233241	1111	15889										
SLC6A8	6535	broad.mit.edu	37	chrX	152958597	152958597	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gatggcatcatttactatctCaagcctgactggtcaaagct	8	10	3	1			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:152958597C>G	uc004fib.3	+	5	1157	c.879C>G	c.(877-879)CTC>CTG	p.L293L	SLC6A8_uc004fic.3_Silent_p.L293L|SLC6A8_uc011myx.1_Silent_p.L178L|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	293	Extracellular (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	TTTACTATCTCAAGCCTGACT	0.632													0	0	0	0.000602	0	5	9										G	152958597	C	G	152958597	2	3	54	1	0	0	0	0	0	0	0	1	14690	813	29	1		1	SLC6A8	23	152958597	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	4921278	152958597	2311963	1112	15890										
FAM50A	9130	broad.mit.edu	37	chrX	153674218	153674218	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gctctggtgaaggagcgggaGaagcagctggccaagaagga	18	7	1	3			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:153674218G>C	uc004fll.3	+	3	353	c.255G>C	c.(253-255)GAG>GAC	p.E85D		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	85					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGAGCGGGAGAAGCAGCTGG	0.607													0	0	0	0.010729	0	9	25										C	153674218	G	C	153674218	3	2	54	1	0	0	0	0	1	0	0	0	5577	933	33	1	265	1	FAM50A	23	153674218	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08	715621	153674218	1596342	1113	15891										
F8	2157	broad.mit.edu	37	chrX	154088779	154088779	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	ctggagatgaggaactccttCacatacatgctggtaagcag	11	9	1	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrX:154088779C>T	uc004fmt.2	-	25	6999	c.6828G>A	c.(6826-6828)GTG>GTA	p.V2276V	F8_uc004fms.2_Silent_p.V141V	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2276	F5/8 type C 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGAACTCCTTCACATACATGC	0.418													0	0	0	0.004007	0	14	60										T	154088779	C	T	154088779	2	4	54	1	0	0	0	0	0	0	0	1	5350	813	29	1		1	F8	23	154088779	Silent	SNP	C	TCGA-DK-A2I4-01A-11D-A21A-08	414561	154088779	1181781	1114	15892										
TBL1Y	90665	broad.mit.edu	37	chrY	6954349	6954349	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	agatctggagtatgaagcagGatgcatgcgtccacgatctt	12	8	2	2			TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrY:6954349G>A	uc004frb.2	+	16	1818	c.1171G>A	c.(1171-1173)GAT>AAT	p.D391N	TBL1Y_uc004frc.2_Missense_Mutation_p.D391N|TBL1Y_uc004frd.2_Missense_Mutation_p.D391N|TBL1Y_uc011nap.1_Missense_Mutation_p.D233N	NM_033284	NP_150600	Q9BQ87	TBL1Y_HUMAN	transducin beta-like 1Y	391	WD 5.				transcription, DNA-dependent						0						TATGAAGCAGGATGCATGCGT	0.547													0	0	0	0.00499	0	15	43										A	6954349	G	A	6954349	3	1	54	1	0	0	0	0	1	0	0	0	15638	1174	41	1	1213	1	TBL1Y	24	6954349	Missense_Mutation	SNP	G	TCGA-DK-A2I4-01A-11D-A21A-08		6954349	52419217	1115	15893										
KDM5D	8284	broad.mit.edu	37	chrY	21868143	21868143	+	Frame_Shift_Del	DEL	T	T	-													0.606142728093948	671	6.7920727106606e-284	4.51029313391736	5.42167231264976	4.06934644303065	1.30147971379273e-14	2.81987271321758e-13	522	gttgaacaagattctcaacgTttctaccctgatccaccttc							TCGA-DK-A2I4-01A-11D-A21A-08	TCGA-DK-A2I4-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d68074b8-ce96-4dc5-b14c-3bbc7ba92ad9	6e6b0a28-322f-43a0-8abe-bff1727ae6b7	g.chrY:21868143delT	uc004fug.2	-	27	4646	c.4358delA	c.(4357-4359)AACfs	p.N1453fs	KDM5D_uc011naz.1_Frame_Shift_Del_p.N1484fs|KDM5D_uc010nwy.2_Frame_Shift_Del_p.N1396fs|KDM5D_uc004fuf.2_Frame_Shift_Del_p.N628fs	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	1453					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	ATTCTCAACGTTTCTACCCTG	0.512																		2	4	---	---								-	21868143	T	-	21868143	7	5	54	1	0	1	0	1	0	0	0	0	8136	1725	60	0	265	0	KDM5D	24	21868143	Frame_Shift_Del	DEL	T	TCGA-DK-A2I4-01A-11D-A21A-08	14913794	21868143	37505423	1116	15894										
NOC2L	26155	broad.mit.edu	37	chr1	880925	880925	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgagaatccctcggtgtcgtCctcttcagagctgttcaggt	11	12	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:880925C>T	uc001abz.3	-	17	2085	c.2026G>A	c.(2026-2028)GAC>AAC	p.D676N	NOC2L_uc001aby.3_Missense_Mutation_p.D473N|NOC2L_uc009vjq.2_Missense_Mutation_p.D676N	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	676	Asp/Glu-rich (acidic).					nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		TCGGTGTCGTCCTCTTCAGAG	0.577													0	0	0	0.012319	0	21	51										T	880925	C	T	880925	3	4	55	1	0	0	0	0	1	0	0	0	10513	855	30	1	235	1	NOC2L	1	880925	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		880925	248369696	1	15895										
TP73	7161	broad.mit.edu	37	chr1	3624302	3624302	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccgactaccccggaccccacCactttgaggtcactttccag	7	18	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:3624302C>T	uc001akp.2	+	4	486	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	TP73_uc001akq.2_Missense_Mutation_p.H126Y|TP73_uc010nzj.1_Missense_Mutation_p.H77Y|TP73_uc001akr.2_Missense_Mutation_p.H77Y|TP73_uc009vlk.1_Missense_Mutation_p.H77Y|TP73_uc001aks.2_Missense_Mutation_p.H77Y|TP73_uc009vll.2_Missense_Mutation_p.H55Y|TP73_uc010nzk.1_Missense_Mutation_p.H55Y	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	126					cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CGGACCCCACCACTTTGAGGT	0.557													0	0	0	0.00499	0	16	59										T	3624302	C	T	3624302	3	4	55	1	0	0	0	0	1	0	0	0	16390	594	21	2	429	2	TP73	1	3624302	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2743377	3624302	245626319	2	15896										
TNFRSF25	8718	broad.mit.edu	37	chr1	6524508	6524508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cccacagtcagtatctctgcGggaacctgcaatccaggaga	10	13	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:6524508G>A	uc001ane.2	-	5	557	c.469C>T	c.(469-471)CGC>TGC	p.R157C	TNFRSF25_uc001ana.2_Intron|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_5'UTR|TNFRSF25_uc009vlz.2_Intron|TNFRSF25_uc001anf.2_Missense_Mutation_p.R157C|TNFRSF25_uc001ang.2_Missense_Mutation_p.R112C|TNFRSF25_uc001anh.2_Missense_Mutation_p.R157C|TNFRSF25_uc001ani.1_Missense_Mutation_p.R157C	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	157	TNFR-Cys 3.|Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GTATCTCTGCGGGAACCTGCA	0.607													0	0	0	0.013537	0	11	6										A	6524508	G	A	6524508	3	1	55	1	0	0	0	0	1	0	0	0	16293	1116	39	2	839	2	TNFRSF25	1	6524508	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2900206	6524508	242726113	3	15897										
PRDM2	7799	broad.mit.edu	37	chr1	14106203	14106203	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cacaaatagtgaggccaagaAgcggagaactgcgagcccac	12	11	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:14106203A>G	uc001avi.2	+	8	2769	c.1913A>G	c.(1912-1914)AAG>AGG	p.K638R	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.K638R|PRDM2_uc001avj.2_Intron|PRDM2_uc009vod.1_Missense_Mutation_p.K395R|PRDM2_uc001avk.2_Missense_Mutation_p.K437R|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	638						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GAGGCCAAGAAGCGGAGAACT	0.473													0	0	0	0.001984	0	7	29										G	14106203	A	G	14106203	3	3	55	1	0	0	0	0	1	0	0	0	12458	72	3	5	1939	5	PRDM2	1	14106203	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	7581695	14106203	235144418	4	15898										
EPHA2	1969	broad.mit.edu	37	chr1	16475491	16475491	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gccagacatcacgttgcacaCggagtacatgtagatcggca	11	11	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:16475491C>A	uc001aya.1	-	3	342	c.205G>T	c.(205-207)GTG>TTG	p.V69L	EPHA2_uc010oca.1_Missense_Mutation_p.V69L	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	69	Extracellular (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACGTTGCACACGGAGTACATG	0.537													1	0	2.55665e-31	0.01441	2.99182e-31	44	42										A	16475491	C	A	16475491	3	1	55	1	0	0	0	0	1	0	0	0	5167	536	19	4	2785	4	EPHA2	1	16475491	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2369288	16475491	232775130	5	15899										
PADI2	11240	broad.mit.edu	37	chr1	17402183	17402190	+	Frame_Shift_Del	DEL	GGGGATGG	GGGGATGG	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggctagcttacctttgtgccGgggatggggacaaaggacat					rs146438183	byFrequency	TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:17402183_17402190delGGGGATGG	uc001baf.2	-	12	1521_1528	c.1439_1446delCCATCCCC	c.(1438-1446)CCCATCCCCfs	p.P480fs	PADI2_uc010ocm.1_Frame_Shift_Del_p.P364fs	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	480_482					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CCTTTGTGCCGGGGATGGGGACAAAGGA	0.591											OREG0013145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						36	52	---	---								-	17402190	GGGGATGG	-	17402183	7	5	55	1	0	1	0	1	0	0	0	0	11378	1103	39	0	571	0	PADI2	1	17402183	Frame_Shift_Del	DEL	GGGGATGG	TCGA-DK-A2I6-01A-12D-A18F-08	926692	17402183	231848438	6	15900										
RCC2	55920	broad.mit.edu	37	chr1	17738662	17738662	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	accccagctgatggtgctctCatcggcggccacaatgatgc	11	14	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:17738662C>T	uc001bal.2	-	10	1389	c.1342G>A	c.(1342-1344)GAG>AAG	p.E448K	RCC2_uc001bam.2_Missense_Mutation_p.E448K	NM_001136204	NP_001129676	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	448	RCC1 7.				cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle					0		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		ATGGTGCTCTCATCGGCGGCC	0.622													0	0	0	0.009718	0	39	40										T	17738662	C	T	17738662	3	4	55	1	0	0	0	0	1	0	0	0	13174	835	29	1	238	1	RCC2	1	17738662	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	336479	17738662	231511959	7	15901										
ACTL8	81569	broad.mit.edu	37	chr1	18152535	18152535	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggagacagtcgccgtgactCagatgaacaagtgctacgtg	13	9	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:18152535C>T	uc001bat.2	+	3	838	c.622C>T	c.(622-624)CAG>TAG	p.Q208*		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	208						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		CGCCGTGACTCAGATGAACAA	0.562											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009535	0	32	17										T	18152535	C	T	18152535	4	4	55	1	0	0	0	0	0	1	0	0	202	827	29	1	628	1	ACTL8	1	18152535	Nonsense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	413873	18152535	231098086	8	15902										
TMCO4	255104	broad.mit.edu	37	chr1	20107204	20107204	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctgcagtgggctcagctacCagaggctgctgaggcagcct	14	12	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:20107204C>T	uc001bcn.2	-	4	290	c.48G>A	c.(46-48)CTG>CTA	p.L16L	TMCO4_uc001bcm.2_Silent_p.L16L|TMCO4_uc001bco.1_Silent_p.L16L|TMCO4_uc001bcp.1_Silent_p.L16L|TMCO4_uc009vpn.1_Silent_p.L16L|TMCO4_uc001bcq.1_Silent_p.L16L	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	16						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		GCTCAGCTACCAGAGGCTGCT	0.532													0	0	0	0.010504	0	19	18										T	20107204	C	T	20107204	2	4	55	1	0	0	0	0	0	0	0	1	15995	581	21	2		2	TMCO4	1	20107204	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1954669	20107204	229143417	9	15903										
HSPG2	3339	broad.mit.edu	37	chr1	22165877	22165877	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gccttactctccacgtgcagGatgatggtggcctcagcgtg	13	12	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:22165877G>A	uc001bfj.2	-	73	9916	c.9876C>T	c.(9874-9876)ATC>ATT	p.I3292I	HSPG2_uc009vqd.2_Silent_p.I3293I	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3292	Ig-like C2-type 18.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCACGTGCAGGATGATGGTGG	0.597													0	0	0	0.015359	0	32	24										A	22165877	G	A	22165877	2	1	55	1	0	0	0	0	0	0	0	1	7430	1164	41	1		1	HSPG2	1	22165877	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2058673	22165877	227084744	10	15904										
ASAP3	55616	broad.mit.edu	37	chr1	23782407	23782407	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agcgcagcaacctcgcgggtGaacacggccaagtttaggaa	13	11	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:23782407G>A	uc001bha.2	-	3	439	c.315C>T	c.(313-315)TTC>TTT	p.F105F	ASAP3_uc010odz.1_5'UTR|ASAP3_uc010oea.1_Silent_p.F105F|ASAP3_uc001bhc.1_Silent_p.F105F	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	105					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CCTCGCGGGTGAACACGGCCA	0.557													0	0	0	0.01441	0	93	46										A	23782407	G	A	23782407	2	1	55	1	0	0	0	0	0	0	0	1	1012	1281	45	1		1	ASAP3	1	23782407	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1616530	23782407	225468214	11	15905										
GALE	2582	broad.mit.edu	37	chr1	24124627	24124627	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctccagaagctggatggtccCggtcaggttaactctgtaat	11	10	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:24124627C>G	uc009vqo.1	-	4	541	c.331G>C	c.(331-333)GGG>CGG	p.G111R	GALE_uc001bhv.1_Missense_Mutation_p.G111R|GALE_uc001bhw.1_Missense_Mutation_p.G111R|GALE_uc001bhx.1_Missense_Mutation_p.G111R|GALE_uc009vqp.1_Missense_Mutation_p.G111R|GALE_uc001bhy.1_Missense_Mutation_p.G111R|GALE_uc001bhz.1_Missense_Mutation_p.G37R|GALE_uc001bia.2_5'Flank|GALE_uc009vqq.1_3'UTR	NM_001127621	NP_001121093	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	111					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		TGGATGGTCCCGGTCAGGTTA	0.592													0	0	0	0.010729	0	10	109										G	24124627	C	G	24124627	3	3	55	1	0	0	0	0	1	0	0	0	6202	652	23	4	747	4	GALE	1	24124627	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	342220	24124627	225125994	12	15906										
C1orf130	400746	broad.mit.edu	37	chr1	24932122	24932122	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgaggacgaggcgggaactaGagcccaagggccccaagcca	15	12	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:24932122G>A	uc001bjk.1	+	4	259	c.193G>A	c.(193-195)GAG>AAG	p.E65K		NM_001010980	NP_001010980	Q5T1S8	CA130_HUMAN	chromosome 1 open reading frame 130	65						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0119)|all_lung(284;0.0154)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0439)|OV - Ovarian serous cystadenocarcinoma(117;1.48e-24)|Colorectal(126;6.93e-08)|COAD - Colon adenocarcinoma(152;3.69e-06)|GBM - Glioblastoma multiforme(114;0.00036)|BRCA - Breast invasive adenocarcinoma(304;0.00189)|KIRC - Kidney renal clear cell carcinoma(1967;0.00382)|STAD - Stomach adenocarcinoma(196;0.00521)|READ - Rectum adenocarcinoma(331;0.0659)|Lung(427;0.144)		GCGGGAACTAGAGCCCAAGGG	0.587													0	0	0	0.01441	0	51	29										A	24932122	G	A	24932122	3	1	55	1	0	0	0	0	1	0	0	0	1997	943	33	1	203	1	C1orf130	1	24932122	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	807495	24932122	224318499	13	15907										
C1orf135	79000	broad.mit.edu	37	chr1	26161564	26161564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttcagattttgagttggccCatcctcctggcactgagccc	9	14	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:26161564C>T	uc001bkw.1	-	3	994	c.994G>A	c.(994-996)GGG>AGG	p.G332R		NM_024037	NP_076942	Q9H7T9	CA135_HUMAN	aurora A-binding protein	332											0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		TGAGTTGGCCCATCCTCCTGG	0.443													0	0	0	0.017118	0	35	492										T	26161564	C	T	26161564	3	4	55	1	0	0	0	0	1	0	0	0	1999	594	21	2	83	2	C1orf135	1	26161564	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1229442	26161564	223089057	14	15908										
LIN28A	79727	broad.mit.edu	37	chr1	26752761	26752761	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	actgtggaggtctagatcatCatgccaaggaatgcaagctg	12	8	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:26752761C>T	uc001bmj.2	+	4	556	c.442C>T	c.(442-444)CAT>TAT	p.H148Y	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	148	CCHC-type 1.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						TCTAGATCATCATGCCAAGGA	0.423													0	0	0	0.01892	0	21	65										T	26752761	C	T	26752761	3	4	55	1	0	0	0	0	1	0	0	0	8805	826	29	1	456	1	LIN28A	1	26752761	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	591197	26752761	222497860	15	15909										
SFN	2810	broad.mit.edu	37	chr1	27189796	27189796	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttcatgaaaggcgccgtggaGaagggcgaggagctctcctg	16	9	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:27189796G>C	uc001bnc.1	+	1	164	c.93G>C	c.(91-93)GAG>GAC	p.E31D	uc010ofi.1_RNA	NM_006142	NP_006133	P31947	1433S_HUMAN	stratifin	31					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity				0		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		GCGCCGTGGAGAAGGGCGAGG	0.607													0	0	0	0.013537	0	13	114										C	27189796	G	C	27189796	3	2	55	1	0	0	0	0	1	0	0	0	14159	933	33	1	95	1	SFN	1	27189796	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	437035	27189796	222060825	16	15910										
FAM46B	115572	broad.mit.edu	37	chr1	27332436	27332436	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttctggccagggtctgagtCagttacaaggcagccaggtg	14	10	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:27332436C>G	uc010ofj.1	-	2	1449	c.1277G>C	c.(1276-1278)TGA>TCA	p.*426S		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	426										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		GGGTCTGAGTCAGTTACAAGG	0.622													0	0	0	0.01441	0	81	54										G	27332436	C	G	27332436	4	3	55	1	0	0	0	0	0	0	0	0	5566	837	29	1	4	1	FAM46B	1	27332436	Nonstop_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	142640	27332436	221918185	17	15911										
XKR8	55113	broad.mit.edu	37	chr1	28290197	28290197	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagagtggccgggctgagtaCtaccagtgtgagtgaaggcc	16	9	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:28290197C>T	uc001bph.1	+	2	560	c.483C>T	c.(481-483)TAC>TAT	p.Y161Y		NM_018053	NP_060523	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related	161	Helical; (Potential).					integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		GGGCTGAGTACTACCAGTGTG	0.567													0	0	0	0.010729	0	12	4										T	28290197	C	T	28290197	2	4	55	1	0	0	0	0	0	0	0	1	17434	576	20	2		2	XKR8	1	28290197	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	957761	28290197	220960424	18	15912										
YTHDF2	51441	broad.mit.edu	37	chr1	29095440	29095440	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atttttttcttacctctgtaGgaacgtcaaggtcgtgggaa	10	7	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:29095440G>A	uc001brc.2	+	5	2214	c.1717_splice	c.e5-1	p.E573_splice	YTHDF2_uc001brd.2_Splice_Site_p.E570_splice|YTHDF2_uc010ofx.1_Splice_Site_p.E523_splice|YTHDF2_uc001bre.2_Splice_Site_p.E523_splice	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8						humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		TACCTCTGTAGGAACGTCAAG	0.328													0	0	0	0.001168	0	5	20										A	29095440	G	A	29095440	5	1	55	1	0	0	0	0	0	0	1	0	17496	1014	35	2	1734	2	YTHDF2	1	29095440	Splice_Site	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	805243	29095440	220155181	19	15913										
CSMD2	114784	broad.mit.edu	37	chr1	34238233	34238233	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcatgtgattgccttctgtcCcaccagctcaaaggcgggct	11	13	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:34238233C>G	uc001bxn.1	-	13	1692	c.1663G>C	c.(1663-1665)GGA>CGA	p.G555R	CSMD2_uc001bxm.1_Missense_Mutation_p.G595R	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	555	Sushi 3.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCCTTCTGTCCCACCAGCTCA	0.577													0	0	0	0.001168	0	5	101										G	34238233	C	G	34238233	3	3	55	1	0	0	0	0	1	0	0	0	3945	632	22	4	9028	4	CSMD2	1	34238233	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5142793	34238233	215012388	20	15914										
CAP1	10487	broad.mit.edu	37	chr1	40525754	40525754	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tttagcaggagcagctccatAtgtgcaggcatttgactcgc	11	10	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:40525754A>G	uc001cfa.3	+	3	357	c.128A>G	c.(127-129)TAT>TGT	p.Y43C	CAP1_uc010ojd.1_RNA|CAP1_uc001cey.3_Missense_Mutation_p.Y43C|CAP1_uc001cez.3_Missense_Mutation_p.Y43C|CAP1_uc009vvz.2_Missense_Mutation_p.Y43C|CAP1_uc010oje.1_Missense_Mutation_p.M13V	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	43					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCAGCTCCATATGTGCAGGCA	0.458													0	0	0	0.016522	0	22	26										G	40525754	A	G	40525754	3	3	55	1	0	0	0	0	1	0	0	0	2619	449	16	5	134	5	CAP1	1	40525754	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	6287521	40525754	208724867	21	15915										
KIAA0494	9813	broad.mit.edu	37	chr1	47181986	47181986	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttgttcgaaatttttccttGagggcatccagatcctcctt	7	11	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:47181986G>A	uc001cqk.3	-	2	1292	c.315C>T	c.(313-315)CTC>CTT	p.L105L	KIAA0494_uc010omh.1_Silent_p.L105L|KIAA0494_uc001cql.1_Silent_p.L105L	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	105							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					ATTTTTCCTTGAGGGCATCCA	0.338													0	0	0	0.008291	0	11	27										A	47181986	G	A	47181986	2	1	55	1	0	0	0	0	0	0	0	1	8179	1277	45	1		1	KIAA0494	1	47181986	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6656232	47181986	202068635	22	15916										
LEPR	3953	broad.mit.edu	37	chr1	66102578	66102578	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgctcacactttgtagaaaaTaatatcaacttaggaacttc	5	8	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:66102578T>C	uc001dci.2	+	20	3580	c.3378T>C	c.(3376-3378)AAT>AAC	p.N1126N	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	1126	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTGTAGAAAATAATATCAACT	0.403													0	0	0	0.001168	0	5	22										C	66102578	T	C	66102578	2	2	55	1	0	0	0	0	0	0	0	1	8728	1403	49	5		5	LEPR	1	66102578	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	18920592	66102578	183148043	23	15917										
ANKRD34A	284615	broad.mit.edu	37	chr1	145474162	145474162	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	actgccgaattcaatggcctGaccctgaccggtcgaccccg	10	16	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:145474162G>T	uc001enq.1	+	4	2127	c.834G>T	c.(832-834)CTG>CTT	p.L278L	NBPF10_uc001emp.3_Intron|LIX1L_uc001enr.2_5'Flank	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	278	Pro-rich.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCAATGGCCTGACCCTGACCG	0.652													1	0	7.41877e-09	0.012319	8.30601e-09	22	41										T	145474162	G	T	145474162	2	4	55	1	0	0	0	0	0	0	0	1	662	1277	45	3		3	ANKRD34A	1	145474162	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	79371584	145474162	103776459	24	15918										
UBAP2L	9898	broad.mit.edu	37	chr1	154224128	154224128	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcctgtataccagcacggccAggtagaggaaacattaacca	10	11	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:154224128A>G	uc001fep.3	+	14	1830	c.1663A>G	c.(1663-1665)AGT>GGT	p.S555G	UBAP2L_uc009wot.2_Missense_Mutation_p.S555G|UBAP2L_uc010pek.1_Missense_Mutation_p.S547G|UBAP2L_uc010pel.1_Missense_Mutation_p.S565G|UBAP2L_uc010pen.1_Missense_Mutation_p.S469G	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	555					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGCACGGCCAGGTAGAGGAA	0.493													0	0	0	0.010818	0	31	225										G	154224128	A	G	154224128	3	3	55	1	0	0	0	0	1	0	0	0	16835	202	7	5	1713	5	UBAP2L	1	154224128	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	8749966	154224128	95026493	25	15919										
LMNA	4000	broad.mit.edu	37	chr1	156100457	156100457	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgctcaggctcggctgaagGacctggaggctctgctgaac	14	12	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:156100457G>A	uc001fni.2	+	2	655	c.406G>A	c.(406-408)GAC>AAC	p.D136N	LMNA_uc001fnf.1_Missense_Mutation_p.D136N|LMNA_uc001fng.2_Missense_Mutation_p.D136N|LMNA_uc001fnh.2_Missense_Mutation_p.D136N|LMNA_uc009wro.1_Missense_Mutation_p.D136N|LMNA_uc010pgz.1_Missense_Mutation_p.D24N|LMNA_uc001fnj.2_Missense_Mutation_p.D55N|LMNA_uc001fnk.2_Missense_Mutation_p.D37N	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	136	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					TCGGCTGAAGGACCTGGAGGC	0.572									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome		OREG0013866	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	72	28										A	156100457	G	A	156100457	3	1	55	1	0	0	0	0	1	0	0	0	8848	1174	41	1	412	1	LMNA	1	156100457	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1876329	156100457	93150164	26	15920										
PRCC	5546	broad.mit.edu	37	chr1	156756616	156756616	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccactccgtcgccctctgctAtcaaggctgctgccaagagt	9	16	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:156756616A>G	uc001fqa.2	+	3	1023	c.733A>G	c.(733-735)ATC>GTC	p.I245V	PRCC_uc001fqb.2_Missense_Mutation_p.I245V	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	245					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCCTCTGCTATCAAGGCTGC	0.552			T	TFE3	papillary renal 								0	0	0	0.010729	0	9	23										G	156756616	A	G	156756616	3	3	55	1	0	0	0	0	1	0	0	0	12447	449	16	5	743	5	PRCC	1	156756616	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	656159	156756616	92494005	27	15921										
DCAF6	55827	broad.mit.edu	37	chr1	167906233	167906233	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gaggacccgtcccggctgcgGagtcgatacctgggtgagcg	17	12	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:167906233G>A	uc001gew.2	+	1	326	c.84G>A	c.(82-84)CGG>CGA	p.R28R	BRP44_uc001ges.2_5'Flank|BRP44_uc001get.2_5'UTR|BRP44_uc001geu.2_Intron|BRP44_uc009wvn.2_5'Flank|DCAF6_uc001gev.2_Silent_p.R28R|DCAF6_uc001gex.2_Silent_p.R28R|DCAF6_uc010plk.1_Silent_p.R28R	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	28					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CCCGGCTGCGGAGTCGATACC	0.711													0	0	0	0.020292	0	11	17										A	167906233	G	A	167906233	2	1	55	1	0	0	0	0	0	0	0	1	4274	1161	41	1		1	DCAF6	1	167906233	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	11149617	167906233	81344388	28	15922										
F5	2153	broad.mit.edu	37	chr1	169519105	169519105	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agtcctattagcccagaggcGatgtctctcatgatgtccac	9	12	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:169519105G>A	uc001ggg.1	-	10	1690	c.1545C>T	c.(1543-1545)ATC>ATT	p.I515I	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	515	F5/8 type A 2.|Plastocyanin-like 3.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GCCCAGAGGCGATGTCTCTCA	0.423													0	0	0	0.008291	0	9	48										A	169519105	G	A	169519105	2	1	55	1	0	0	0	0	0	0	0	1	5348	1048	37	1		1	F5	1	169519105	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1612872	169519105	79731516	29	15923										
SCYL3	57147	broad.mit.edu	37	chr1	169845137	169845137	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acctctggtgtggcctgagaAactttacaaacagtttccat	8	10	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:169845137A>C	uc001ggs.2	-	4	645	c.447T>G	c.(445-447)GTT>GTG	p.V149V	SCYL3_uc001ggt.2_Silent_p.V149V|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	149	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGCCTGAGAAACTTTACAAA	0.463													0	0	0	0.009096	0	3	41										C	169845137	A	C	169845137	2	2	55	1	0	0	0	0	0	0	0	1	13949	1	1	5		5	SCYL3	1	169845137	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	326032	169845137	79405484	30	15924										
RASAL2	9462	broad.mit.edu	37	chr1	178269155	178269155	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaagggggacaggagcagcAgacagattccaccaaagggc	16	9	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:178269155A>G	uc001glq.2	+	3	1123	c.359A>G	c.(358-360)CAG>CGG	p.Q120R	RASAL2_uc009wxb.2_Missense_Mutation_p.Q120R	NM_170692	NP_733793	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 2	Error:Variant_position_missing_in_Q9UJF2_after_alignment					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity	p.E120*(1)		ovary(2)|breast(2)|large_intestine(1)	5						CAGGAGCAGCAGACAGATTCC	0.478											OREG0014010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	23	29										G	178269155	A	G	178269155	3	3	55	1	0	0	0	0	1	0	0	0	13064	188	7	5	369	5	RASAL2	1	178269155	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	8424018	178269155	70981466	31	15925										
KIF21B	23046	broad.mit.edu	37	chr1	200954055	200954055	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acattgcggtcattgcggggCcgagtgggaggggatgatgg	20	6	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:200954055C>T	uc001gvs.1	-	27	4052	c.3735G>A	c.(3733-3735)CGG>CGA	p.R1245R	KIF21B_uc001gvr.1_Silent_p.R1245R|KIF21B_uc009wzl.1_Silent_p.R1245R|KIF21B_uc010ppn.1_Silent_p.R1245R	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1245					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CATTGCGGGGCCGAGTGGGAG	0.627													0	0	0	0.010504	0	20	41										T	200954055	C	T	200954055	2	4	55	1	0	0	0	0	0	0	0	1	8289	726	26	2		2	KIF21B	1	200954055	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	22684900	200954055	48296566	32	15926										
NAV1	89796	broad.mit.edu	37	chr1	201779122	201779122	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctaccctgggactaagcactGagtccatccatggctacagc	9	14	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:201779122G>C	uc001gwu.2	+	22	4788	c.4441G>C	c.(4441-4443)GAG>CAG	p.E1481Q	NAV1_uc001gwx.2_Missense_Mutation_p.E1090Q	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1484					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						ACTAAGCACTGAGTCCATCCA	0.478													0	0	0	0.021523	0	25	43										C	201779122	G	C	201779122	3	2	55	1	0	0	0	0	1	0	0	0	10183	1291	45	1	4597	1	NAV1	1	201779122	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	825067	201779122	47471499	33	15927										
TIMM17A	10440	broad.mit.edu	37	chr1	201932815	201932815	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttcaagtcagaggaaaggaaGatccctggaactccatcaca	9	10	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:201932815G>A	uc001gxc.2	+	4	298	c.262G>A	c.(262-264)GAT>AAT	p.D88N		NM_006335	NP_006326	Q99595	TI17A_HUMAN	translocase of inner mitochondrial membrane 17	88					protein targeting to mitochondrion	integral to membrane|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity				0						AGGAAAGGAAGATCCCTGGAA	0.418													0	0	0	0.00499	0	18	20										A	201932815	G	A	201932815	3	1	55	1	0	0	0	0	1	0	0	0	15905	942	33	1	276	1	TIMM17A	1	201932815	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	153693	201932815	47317806	34	15928										
CNIH3	149111	broad.mit.edu	37	chr1	224922305	224922305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atagctcagaactagcctacGacccaccggtggtcatgaat	9	12	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:224922305G>A	uc001hos.1	+	5	1050	c.352G>A	c.(352-354)GAC>AAC	p.D118N		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	118	Cytoplasmic (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		ACTAGCCTACGACCCACCGGT	0.517													0	0	0	0.008361	0	29	41										A	224922305	G	A	224922305	3	1	55	1	0	0	0	0	1	0	0	0	3604	1058	37	1	370	1	CNIH3	1	224922305	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	22989490	224922305	24328316	35	15929										
C1orf55	163859	broad.mit.edu	37	chr1	226175920	226175920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tccatggtctgtattcactaCtctcgccctctgagaaccac	6	15	4	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:226175920C>T	uc001hpu.3	-	6	864	c.811G>A	c.(811-813)GTA>ATA	p.V271I	C1orf55_uc001hpv.2_Missense_Mutation_p.V271I	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	271										lung(1)	1	Breast(184;0.197)					GTATTCACTACTCTCGCCCTC	0.502													0	0	0	0.004656	0	22	159										T	226175920	C	T	226175920	3	4	55	1	0	0	0	0	1	0	0	0	2047	565	20	2	552	2	C1orf55	1	226175920	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1253615	226175920	23074701	36	15930										
CABC1	56997	broad.mit.edu	37	chr1	227152913	227152913	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccctttagagaagccgggttCcccggccaggcctcctcccc	10	19	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:227152913C>T	uc001hqm.1	+	8	3809	c.390C>T	c.(388-390)TTC>TTT	p.F130F	CABC1_uc010pvp.1_Silent_p.F93F|CABC1_uc001hqn.1_Silent_p.F130F|CABC1_uc009xeq.1_Silent_p.F78F|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	130					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				AAGCCGGGTTCCCCGGCCAGG	0.657													0	0	0	0.00499	0	16	28										T	227152913	C	T	227152913	2	4	55	1	0	0	0	0	0	0	0	1	2527	854	30	1		1	CABC1	1	227152913	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	976993	227152913	22097708	37	15931										
PLD5	200150	broad.mit.edu	37	chr1	242383325	242383325	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccagtccaaaccggcactgcCgatatacacgtgctgtttgt	9	13	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:242383325C>A	uc001hzn.1	-	5	827	c.700G>T	c.(700-702)GGC>TGC	p.G234C	PLD5_uc001hzl.3_Missense_Mutation_p.G172C|PLD5_uc001hzm.3_Missense_Mutation_p.G24C|PLD5_uc001hzo.1_Missense_Mutation_p.G142C			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	234	PLD phosphodiesterase 1.					integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CCGGCACTGCCGATATACACG	0.517													1	0	4.7546e-09	0.004007	5.35045e-09	15	25										A	242383325	C	A	242383325	3	1	55	1	0	0	0	0	1	0	0	0	12049	652	23	4	934	4	PLD5	1	242383325	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	15230412	242383325	6867296	38	15932										
OR2L8	391190	broad.mit.edu	37	chr1	248112660	248112660	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tatgtactccatattccttaTtgccgatccagggccatcaa	6	12	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:248112660T>C	uc001idt.1	+	1	501	c.501T>C	c.(499-501)TAT>TAC	p.Y167Y	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATATTCCTTATTGCCGATCCA	0.473													0	0	0	0.007291	0	26	92										C	248112660	T	C	248112660	2	2	55	1	0	0	0	0	0	0	0	1	11009	1500	52	5		5	OR2L8	1	248112660	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	5729335	248112660	1137961	39	15933										
OR2L3	391192	broad.mit.edu	37	chr1	248224484	248224484	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tatgtactccatattccttaTtgccaatccagggccatcaa	5	12	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr1:248224484T>C	uc001idx.1	+	1	501	c.501T>C	c.(499-501)TAT>TAC	p.Y167Y	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATATTCCTTATTGCCAATCCA	0.463													0	0	0	0.00499	0	9	61										C	248224484	T	C	248224484	2	2	55	1	0	0	0	0	0	0	0	1	11008	1500	52	5		5	OR2L3	1	248224484	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	111824	248224484	1026137	40	15934										
KIDINS220	57498	broad.mit.edu	37	chr2	8919881	8919894	+	Frame_Shift_Del	DEL	TCTGAGTGAAGCTG	TCTGAGTGAAGCTG	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gaccaccagccttgtctgatTctgagtgaagctgtcaatgg							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:8919881_8919894delTCTGAGTGAAGCTG	uc002qzc.2	-	18	2462_2475	c.2280_2293delCAGCTTCACTCAGA	c.(2278-2295)GACAGCTTCACTCAGAATfs	p.D760fs	KIDINS220_uc010yiv.1_Frame_Shift_Del_p.D526fs|KIDINS220_uc002qzd.2_Frame_Shift_Del_p.D718fs|KIDINS220_uc010yiw.1_Frame_Shift_Del_p.D761fs	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	760_765	KAP NTPase.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CTTGTCTGATTCTGAGTGAAGCTGTCAATGGTTT	0.458																		13	39	---	---								-	8919894	TCTGAGTGAAGCTG	-	8919881	7	5	55	1	0	1	0	1	0	0	0	0	8271	1783	62	0	3074	0	KIDINS220	2	8919881	Frame_Shift_Del	DEL	TCTGAGTGAAGCTG	TCGA-DK-A2I6-01A-12D-A18F-08		8919881	234279492	41	15935										
ITSN2	50618	broad.mit.edu	37	chr2	24535188	24535188	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcagtttgatgagtttcataGctatggagaactcttgctga	10	6	3	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:24535188G>A	uc002rfe.2	-	5	503	c.245C>T	c.(244-246)GCT>GTT	p.A82V	ITSN2_uc002rff.2_Missense_Mutation_p.A82V|ITSN2_uc002rfg.2_Missense_Mutation_p.A82V|ITSN2_uc010eyd.2_Missense_Mutation_p.A82V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	82	EH 1.|EF-hand 1.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGTTTCATAGCTATGGAGAA	0.443													0	0	0	0.00874	0	40	58										A	24535188	G	A	24535188	3	1	55	1	0	0	0	0	1	0	0	0	7927	971	34	2	5043	2	ITSN2	2	24535188	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	15615307	24535188	218664185	42	15936										
ZNF513	130557	broad.mit.edu	37	chr2	27603386	27603386	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcgggtggctttgcttccttCggggcatcgtgaccggctcc	15	13	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:27603386C>T	uc002rkk.2	-	1	208	c.8G>A	c.(7-9)CGA>CAA	p.R3Q	ZNF513_uc002rkj.2_5'Flank	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	3					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGCTTCCTTCGGGGCATCGT	0.697													0	0	0	0.006214	0	7	8										T	27603386	C	T	27603386	3	4	55	1	0	0	0	0	1	0	0	0	17955	884	31	1	1633	1	ZNF513	2	27603386	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	3068198	27603386	215595987	43	15937										
BIRC6	57448	broad.mit.edu	37	chr2	32738106	32738107	+	Missense_Mutation	DNP	GG	GG	AT													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	actcctcaacagtagagtatGgtcttctgatgccatctcct							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:32738106_32738107GG>AT	uc010ezu.2	+	54	10587_10588	c.10453_10454GG>AT	c.(10453-10455)GGT>ATT	p.G3485I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3485					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGTAGAGTATGGTCTTCTGATG	0.455													0	0	0	0.004672	0	10	81										AT	32738107	GG	AT	32738106	3	1	55	1	0	0	0	0	1	0	0	0	1438	1348	47	2	10667	2	BIRC6	2	32738106	Missense_Mutation	DNP	GG	TCGA-DK-A2I6-01A-12D-A18F-08	5134720	32738106	210461267	44	15938										
MAP4K3	8491	broad.mit.edu	37	chr2	39499674	39499674	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atacaaccatgtacaccttcGagggaatagctgattaaaaa	7	8	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:39499674G>A	uc002rro.2	-	25	1895	c.1804C>T	c.(1804-1806)CGA>TGA	p.R602*	MAP4K3_uc002rrp.2_Nonsense_Mutation_p.R581*|MAP4K3_uc010yns.1_Nonsense_Mutation_p.R155*	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	602	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				GTACACCTTCGAGGGAATAGC	0.294													0	0	0	0.005524	0	32	72										A	39499674	G	A	39499674	4	1	55	1	0	0	0	0	0	1	0	0	9261	1066	37	1	920	1	MAP4K3	2	39499674	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6761568	39499674	203699699	45	15939										
SPRED2	200734	broad.mit.edu	37	chr2	65543912	65543912	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggggtatgagtcgtggaggtGgcccagggtataaatcctcc	16	8	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:65543912G>A	uc002sdr.3	-	5	1079	c.544C>T	c.(544-546)CAC>TAC	p.H182Y	SPRED2_uc010fcw.2_Missense_Mutation_p.H179Y	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	182					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TCGTGGAGGTGGCCCAGGGTA	0.537													0	0	0	0.004482	0	9	25										A	65543912	G	A	65543912	3	1	55	1	0	0	0	0	1	0	0	0	15092	1348	47	2	720	2	SPRED2	2	65543912	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	26044238	65543912	177655461	46	15940										
SLC4A5	57835	broad.mit.edu	37	chr2	74531720	74531720	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gccgcaggccccagtggactTtttgcaggcctgaaagatgt	13	11	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:74531720T>G	uc002sko.1	-	2	169	c.167A>C	c.(166-168)AAA>ACA	p.K56T	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.K56T|SLC4A5_uc010ffc.1_Missense_Mutation_p.K56T|SLC4A5_uc002skp.1_Intron|SLC4A5_uc002sks.1_Missense_Mutation_p.K56T	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	56	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						CCAGTGGACTTTTTGCAGGCC	0.572													0	0	0	0.012213	0	32	182										G	74531720	T	G	74531720	3	3	55	1	0	0	0	0	1	0	0	0	14657	1841	64	5	3346	5	SLC4A5	2	74531720	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	8987808	74531720	168667653	47	15941										
DQX1	165545	broad.mit.edu	37	chr2	74752218	74752218	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagggtcaggtccatctcatCagcaacccgcagagccaggc	11	15	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:74752218C>T	uc010yrw.1	-	3	514	c.349G>A	c.(349-351)GAT>AAT	p.D117N	DQX1_uc002smc.2_5'Flank	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	117	Helicase ATP-binding.					nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						TCCATCTCATCAGCAACCCGC	0.622													0	0	0	0.013726	0	33	179										T	74752218	C	T	74752218	3	4	55	1	0	0	0	0	1	0	0	0	4751	826	29	1	1844	1	DQX1	2	74752218	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	220498	74752218	168447155	48	15942										
REG1B	5968	broad.mit.edu	37	chr2	79312628	79312628	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgcctctcacctgagcatgaAgtcaggcttgcacagtagcc	10	13	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:79312628A>C	uc002sny.2	-	5	535	c.423T>G	c.(421-423)ACT>ACG	p.T141T		NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	141	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						CTGAGCATGAAGTCAGGCTTG	0.547													0	0	0	0.021022	0	37	81										C	79312628	A	C	79312628	2	2	55	1	0	0	0	0	0	0	0	1	13211	59	3	5		5	REG1B	2	79312628	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	4560410	79312628	163886745	49	15943										
CTNNA2	1496	broad.mit.edu	37	chr2	80646672	80646672	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcaaagagcggaaatgaaaaGgaagtgaaagaatatgccca	12	5	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:80646672G>A	uc010ysh.1	+	8	1241	c.1236G>A	c.(1234-1236)AAG>AAA	p.K412K	CTNNA2_uc010yse.1_Silent_p.K412K|CTNNA2_uc010ysf.1_Silent_p.K412K|CTNNA2_uc010ysg.1_Silent_p.K412K|CTNNA2_uc010ysi.1_Silent_p.K44K	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	412					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAAATGAAAAGGAAGTGAAAG	0.453													0	0	0	0.01892	0	24	64										A	80646672	G	A	80646672	2	1	55	1	0	0	0	0	0	0	0	1	4013	991	35	2		2	CTNNA2	2	80646672	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1334044	80646672	162552701	50	15944										
USP39	10713	broad.mit.edu	37	chr2	85852670	85852684	+	In_Frame_Del	DEL	GAAGCCCACTTTCAC	GAAGCCCACTTTCAC	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tttgctttgcagtatgtgttGaagcccactttcacaaagca							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:85852670_85852684delGAAGCCCACTTTCAC	uc002sqe.2	+	5	615_629	c.579_593delGAAGCCCACTTTCAC	c.(577-594)TTGAAGCCCACTTTCACA>TTA	p.KPTFT194del	USP39_uc002sqb.2_5'UTR|USP39_uc010ysu.1_In_Frame_Del_p.KPTFT116del|USP39_uc010ysv.1_In_Frame_Del_p.KPTFT91del|USP39_uc010fgn.1_In_Frame_Del_p.KPTFT194del|USP39_uc002sqf.2_In_Frame_Del_p.KPTFT194del|USP39_uc002sqg.2_In_Frame_Del_p.KPTFT194del|USP39_uc010fgo.2_In_Frame_Del_p.KPTFT194del	NM_006590	NP_006581	Q53GS9	SNUT2_HUMAN	ubiquitin specific protease 39	194_198					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1						AGTATGTGTTGAAGCCCACTTTCACAAAGCAGCAA	0.391																		9	80	---	---								-	85852684	GAAGCCCACTTTCAC	-	85852670	7	5	55	1	0	1	0	1	0	0	0	0	17067	1281	45	0	597	0	USP39	2	85852670	In_Frame_Del	DEL	GAAGCCCACTTTCAC	TCGA-DK-A2I6-01A-12D-A18F-08	5205998	85852670	157346703	51	15945										
TRIM43	129868	broad.mit.edu	37	chr2	96259801	96259801	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gacttctcacatgccttccaGaaggaactcacctgcgtcat	7	14	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:96259801G>C	uc002suv.2	+	2	166	c.30G>C	c.(28-30)CAG>CAC	p.Q10H		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	10						intracellular	zinc ion binding			ovary(1)	1						ATGCCTTCCAGAAGGAACTCA	0.483													0	0	0	0.01441	0	108	99										C	96259801	G	C	96259801	3	2	55	1	0	0	0	0	1	0	0	0	16515	933	33	1	32	1	TRIM43	2	96259801	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	10407131	96259801	146939572	52	15946										
SULT1C4	27233	broad.mit.edu	37	chr2	108999925	108999925	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gatggtgggaagccaaagacAaacaccgtattctctatctc	9	10	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:108999925A>G	uc002tea.1	+	5	947	c.574A>G	c.(574-576)AAA>GAA	p.K192E	SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Missense_Mutation_p.K117E	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	192					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						AGCCAAAGACAAACACCGTAT	0.463													0	0	0	0.01441	0	48	28										G	108999925	A	G	108999925	3	3	55	1	0	0	0	0	1	0	0	0	15376	131	5	5	592	5	SULT1C4	2	108999925	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	12740124	108999925	134199448	53	15947										
LIMS1	3987	broad.mit.edu	37	chr2	109292446	109292446	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gccgacggcccatcgaagggCgcgtggtgaacgctatgggc	17	12	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:109292446C>G	uc002teg.2	+	6	726	c.607C>G	c.(607-609)CGC>GGC	p.R203G	LIMS1_uc002tef.2_Missense_Mutation_p.R215G|LIMS1_uc002teh.2_Missense_Mutation_p.R203G|LIMS1_uc002tei.2_Missense_Mutation_p.R203G|LIMS1_uc002tej.2_Missense_Mutation_p.R240G|LIMS1_uc002tek.3_Missense_Mutation_p.R265G	NM_004987	NP_004978	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	203	LIM zinc-binding 4.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0						CATCGAAGGGCGCGTGGTGAA	0.542													0	0	0	0.007835	0	43	26										G	109292446	C	G	109292446	3	3	55	1	0	0	0	0	1	0	0	0	8803	768	27	4	625	4	LIMS1	2	109292446	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	292521	109292446	133906927	54	15948										
ACTR3	10096	broad.mit.edu	37	chr2	114713209	114713209	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctttctttagccaaaacctAttgatgtacaagtcattaca	4	9	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:114713209A>G	uc002tkx.1	+	11	1407	c.1087A>G	c.(1087-1089)ATT>GTT	p.I363V	ACTR3_uc010yyc.1_Missense_Mutation_p.I301V|ACTR3_uc010yyd.1_Missense_Mutation_p.I312V	NM_005721	NP_005712	P61158	ARP3_HUMAN	ARP3 actin-related protein 3 homolog	363					cellular component movement|cilium morphogenesis	Arp2/3 protein complex	actin binding|ATP binding			skin(1)	1						GCCAAAACCTATTGATGTACA	0.343													0	0	0	0.001984	0	7	60										G	114713209	A	G	114713209	3	3	55	1	0	0	0	0	1	0	0	0	212	449	16	5	1129	5	ACTR3	2	114713209	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	5420763	114713209	128486164	55	15949										
CNTNAP5	129684	broad.mit.edu	37	chr2	125175130	125175130	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gaatggaatcccagtgggaaGattggcatgagagtcgaggt	16	5	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:125175130G>C	uc002tno.2	+	4	856	c.492G>C	c.(490-492)AAG>AAC	p.K164N	CNTNAP5_uc010flu.2_Missense_Mutation_p.K164N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	164	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCAGTGGGAAGATTGGCATGA	0.498													0	0	0	0.008291	0	10	9										C	125175130	G	C	125175130	3	2	55	1	0	0	0	0	1	0	0	0	3650	933	33	1	506	1	CNTNAP5	2	125175130	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	10461921	125175130	118024243	56	15950										
RIF1	55183	broad.mit.edu	37	chr2	152317679	152317679	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttgaatcttcgtctttaaaaGtaaagggtgaaattcttttg	8	4	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:152317679G>T	uc002txm.2	+	27	3233	c.3103G>T	c.(3103-3105)GTA>TTA	p.V1035L	RIF1_uc002txl.2_Missense_Mutation_p.V1035L|RIF1_uc002txn.2_Missense_Mutation_p.V1035L|RIF1_uc002txo.2_Missense_Mutation_p.V1035L|RIF1_uc002txp.2_5'Flank	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1035					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GTCTTTAAAAGTAAAGGGTGA	0.318													1	0	6.31663e-08	0.003163	7.0541e-08	14	47										T	152317679	G	T	152317679	3	4	55	1	0	0	0	0	1	0	0	0	13359	1029	36	4	3205	4	RIF1	2	152317679	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	27142549	152317679	90881694	57	15951										
CYTIP	9595	broad.mit.edu	37	chr2	158272436	158272436	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agcactcatcatctgtactcGtctgccgactgaaggcaccc	8	15	4	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:158272436G>A	uc002tzj.1	-	8	905	c.833C>T	c.(832-834)ACG>ATG	p.T278M	CYTIP_uc010zcl.1_Missense_Mutation_p.T172M	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	278	Ser-rich.			T -> Q (in Ref. 5; AAA16575).	regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						ATCTGTACTCGTCTGCCGACT	0.542													0	0	0	0.007413	0	20	50										A	158272436	G	A	158272436	3	1	55	1	0	0	0	0	1	0	0	0	4207	1145	40	2	250	2	CYTIP	2	158272436	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	5954757	158272436	84926937	58	15952										
DCAF17	80067	broad.mit.edu	37	chr2	172305301	172305301	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaaaaatccttgagaaaatAtatcttgcaccttattgcaa	6	7	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:172305301A>G	uc002ugx.2	+	4	661	c.432A>G	c.(430-432)ATA>ATG	p.I144M	DCAF17_uc010zdq.1_RNA|DCAF17_uc010fqf.1_Missense_Mutation_p.I144M|DCAF17_uc010zdr.1_RNA	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17 isoform 1	144						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus					0						TTGAGAAAATATATCTTGCAC	0.333													0	0	0	0.012319	0	20	39										G	172305301	A	G	172305301	3	3	55	1	0	0	0	0	1	0	0	0	4269	439	16	5	446	5	DCAF17	2	172305301	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	14032865	172305301	70894072	59	15953										
EVX2	344191	broad.mit.edu	37	chr2	176947052	176947052	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtagcgccgcacttgatccgCgccagagccggagccaccca	12	17	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:176947052C>T	uc010zeu.1	-	2	739	c.553G>A	c.(553-555)GCG>ACG	p.A185T		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	185						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		ACTTGATCCGCGCCAGAGCCG	0.721													0	0	0	0.004672	0	3	11										T	176947052	C	T	176947052	3	4	55	1	0	0	0	0	1	0	0	0	5295	768	27	2	883	2	EVX2	2	176947052	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	4641751	176947052	66252321	60	15954										
TTN	7273	broad.mit.edu	37	chr2	179433786	179433786	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acttctgcaaccttaattggAtcagcagtctgggcaggaag	11	9	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:179433786A>G	uc010zfg.1	-	275	69593	c.69369T>C	c.(69367-69369)GAT>GAC	p.D23123D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D16818D|TTN_uc010zfi.1_Silent_p.D16751D|TTN_uc010zfj.1_Silent_p.D16626D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24050							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTAATTGGATCAGCAGTCT	0.438													0	0	0	0.013726	0	34	79										G	179433786	A	G	179433786	2	3	55	1	0	0	0	0	0	0	0	1	16732	330	12	5		5	TTN	2	179433786	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	2486734	179433786	63765587	61	15955										
TTN	7273	broad.mit.edu	37	chr2	179475984	179475984	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aatgtcatgagtctccaggtCaattgttggcttgcctgtaa	10	8	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:179475984C>T	uc010zfg.1	-	219	43392	c.43168G>A	c.(43168-43170)GAC>AAC	p.D14390N	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D8085N|TTN_uc010zfi.1_Missense_Mutation_p.D8018N|TTN_uc010zfj.1_Missense_Mutation_p.D7893N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15317							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTCCAGGTCAATTGTTGGC	0.353													0	0	0	0.020292	0	14	14										T	179475984	C	T	179475984	3	4	55	1	0	0	0	0	1	0	0	0	16732	826	29	1	57193	1	TTN	2	179475984	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	42198	179475984	63723389	62	15956										
CCDC141	285025	broad.mit.edu	37	chr2	179742771	179742771	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaatagctgccactgcttctCagccgagtcagaacaatgct	8	12	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:179742771C>T	uc002unf.1	-	2	151	c.94G>A	c.(94-96)GAG>AAG	p.E32K	CCDC141_uc002ung.2_Missense_Mutation_p.E607K	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	32							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CACTGCTTCTCAGCCGAGTCA	0.378													0	0	0	0.01892	0	26	35										T	179742771	C	T	179742771	3	4	55	1	0	0	0	0	1	0	0	0	2775	835	29	1	2581	1	CCDC141	2	179742771	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	266787	179742771	63456602	63	15957										
ITGA4	3676	broad.mit.edu	37	chr2	182347105	182347105	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aggcatatatattcagcattGatgaaaaagaactaaatatc	6	5	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:182347105G>A	uc002unu.2	+	8	1622	c.859G>A	c.(859-861)GAT>AAT	p.D287N	ITGA4_uc010zfl.1_Missense_Mutation_p.D287N	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	287	FG-GAP 4.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATTCAGCATTGATGAAAAAGA	0.308													0	0	0	0.003163	0	15	35										A	182347105	G	A	182347105	3	1	55	1	0	0	0	0	1	0	0	0	7878	1290	45	1	889	1	ITGA4	2	182347105	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2604334	182347105	60852268	64	15958										
CALCRL	10203	broad.mit.edu	37	chr2	188245285	188245285	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	taaaccagtttccatcttggTcacagatctttgtaactttt	5	9	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:188245285T>C	uc002upv.3	-	7	865	c.317A>G	c.(316-318)GAC>GGC	p.D106G	CALCRL_uc010frt.2_Missense_Mutation_p.D106G	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	106	Extracellular (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TCCATCTTGGTCACAGATCTT	0.328													0	0	0	0.015359	0	35	86										C	188245285	T	C	188245285	3	2	55	1	0	0	0	0	1	0	0	0	2580	1667	58	5	1104	5	CALCRL	2	188245285	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	5898180	188245285	54954088	65	15959										
DNAH7	56171	broad.mit.edu	37	chr2	196729415	196729415	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cctggaaattctgctgatgtGctctatggcaaatcgaaaca	9	9	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:196729415G>T	uc002utj.3	-	41	7065	c.6964C>A	c.(6964-6966)CAC>AAC	p.H2322N		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2322	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CTGCTGATGTGCTCTATGGCA	0.448													1	0	3.59834e-05	0.001168	3.97806e-05	5	60										T	196729415	G	T	196729415	3	4	55	1	0	0	0	0	1	0	0	0	4606	1319	46	4	5210	4	DNAH7	2	196729415	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	8484130	196729415	46469958	66	15960										
DNAH7	56171	broad.mit.edu	37	chr2	196877531	196877531	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	attttaagtagagtctctttGgcagagtccatgtgtctcat	9	7	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:196877531G>A	uc002utj.3	-	10	1070	c.969C>T	c.(967-969)GCC>GCT	p.A323A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	323	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAGTCTCTTTGGCAGAGTCCA	0.323													0	0	0	0.006214	0	8	55										A	196877531	G	A	196877531	2	1	55	1	0	0	0	0	0	0	0	1	4606	1335	47	2		2	DNAH7	2	196877531	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	148116	196877531	46321842	67	15961										
NIF3L1	60491	broad.mit.edu	37	chr2	201757014	201757014	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagcgcctggtgatccgggcTctggagaacagagtcggtat	16	9	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:201757014T>A	uc002uwm.2	+	2	439	c.348T>A	c.(346-348)GCT>GCA	p.A116A	NIF3L1_uc002uwl.2_Silent_p.A89A|NIF3L1_uc002uwn.2_Silent_p.A89A|NIF3L1_uc002uwo.2_Silent_p.A116A|NIF3L1_uc002uwp.2_Silent_p.A116A|NIF3L1_uc002uwq.2_Silent_p.A116A	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	116					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						TGATCCGGGCTCTGGAGAACA	0.547													0	0	0	0.009535	0	30	53										A	201757014	T	A	201757014	2	1	55	1	0	0	0	0	0	0	0	1	10416	1538	54	5		5	NIF3L1	2	201757014	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	4879483	201757014	41442359	68	15962										
IHH	3549	broad.mit.edu	37	chr2	219920154	219920154	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	accacatcctccaccaccagTgtcccatgctttgtgagcgg	8	16	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:219920154T>G	uc002vjo.1	-	3	1011	c.1011A>C	c.(1009-1011)ACA>ACC	p.T337T		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	337					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCACCACCAGTGTCCCATGCT	0.662													0	0	0	0.021523	0	23	28										G	219920154	T	G	219920154	2	3	55	1	0	0	0	0	0	0	0	1	7607	1683	59	5		5	IHH	2	219920154	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	18163140	219920154	23279219	69	15963										
ABCB6	10058	broad.mit.edu	37	chr2	220075494	220075494	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gggcaatggcgacgcgctgcTtctccccgccgctcagcttc	12	17	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:220075494T>C	uc002vkc.1	-	16	2472	c.2195A>G	c.(2194-2196)AAG>AGG	p.K732R	ABCB6_uc010fwe.1_Missense_Mutation_p.K686R	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	732	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACGCGCTGCTTCTCCCCGCC	0.622													0	0	0	0.008291	0	8	28										C	220075494	T	C	220075494	3	2	55	1	0	0	0	0	1	0	0	0	45	1609	56	5	349	5	ABCB6	2	220075494	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	155340	220075494	23123879	70	15964										
UGT1A9	54600	broad.mit.edu	37	chr2	234580786	234580786	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagttggcaactgggaagatCactgaattgcacagtgaaga	13	6	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:234580786C>A	uc002vus.2	+	1	243	c.206C>A	c.(205-207)TCA>TAA	p.S69*	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Nonsense_Mutation_p.S69*	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	69					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	CTGGGAAGATCACTGAATTGC	0.498													1	0	1.36491e-13	0.016723	1.56804e-13	14	91										A	234580786	C	A	234580786	4	1	55	1	0	0	0	0	0	1	0	0	16949	838	29	3	208	3	UGT1A9	2	234580786	Nonsense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	14505292	234580786	8618587	71	15965										
COL6A3	1293	broad.mit.edu	37	chr2	238283323	238283323	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gacctgtcggccgtgaggacGatcagcagctggggcacacc	15	13	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr2:238283323G>A	uc002vwl.2	-	8	3696	c.3411C>T	c.(3409-3411)ATC>ATT	p.I1137I	COL6A3_uc002vwo.2_Silent_p.I931I|COL6A3_uc010znj.1_Silent_p.I530I|COL6A3_uc002vwq.2_Silent_p.I931I|COL6A3_uc002vwr.2_Silent_p.I730I	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1137	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCGTGAGGACGATCAGCAGCT	0.637													0	0	0	0.009535	0	26	43										A	238283323	G	A	238283323	2	1	55	1	0	0	0	0	0	0	0	1	3701	1048	37	1		1	COL6A3	2	238283323	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3702537	238283323	4916050	72	15966										
ITPR1	3708	broad.mit.edu	37	chr3	4709127	4709127	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atgatgtgttggctgaagacActatcactgccctgctccac	9	12	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:4709127A>T	uc003bqa.2	+	18	2128	c.1780A>T	c.(1780-1782)ACT>TCT	p.T594S	ITPR1_uc010hca.1_Missense_Mutation_p.T579S|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.T579S	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	594	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGCTGAAGACACTATCACTGC	0.458													0	0	0	0.007835	0	43	15										T	4709127	A	T	4709127	3	4	55	1	0	0	0	0	1	0	0	0	7920	159	6	5	1842	5	ITPR1	3	4709127	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08		4709127	193313303	73	15967										
NUP210	23225	broad.mit.edu	37	chr3	13363766	13363766	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcaaagacggccggcttgaaCtgggactggcagctgatgag	15	9	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:13363766C>T	uc003bxv.1	-	35	4925	c.4842G>A	c.(4840-4842)CAG>CAA	p.Q1614Q		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1614	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CCGGCTTGAACTGGGACTGGC	0.557													0	0	0	0.01441	0	153	99										T	13363766	C	T	13363766	2	4	55	1	0	0	0	0	0	0	0	1	10760	564	20	2		2	NUP210	3	13363766	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	8654639	13363766	184658664	74	15968										
NEK10	152110	broad.mit.edu	37	chr3	27326126	27326126	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtccttatcccccaacataaTgttgtttggtgtcagatctc	7	11	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:27326126T>C	uc003cdt.1	-	23	2255	c.1981A>G	c.(1981-1983)ATT>GTT	p.I661V	NEK10_uc003cds.1_Missense_Mutation_p.I58V	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	661	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						CCCAACATAATGTTGTTTGGT	0.328													0	0	0	0.013114	0	39	55										C	27326126	T	C	27326126	3	2	55	1	0	0	0	0	1	0	0	0	10322	1464	51	5	169	5	NEK10	3	27326126	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	13962360	27326126	170696304	75	15969										
TRANK1	9881	broad.mit.edu	37	chr3	36898029	36898029	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggcctgggattgaggtcgaTcaccgcgtactcaagctcac	12	12	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:36898029T>C	uc003cgj.2	-	3	1704	c.1402A>G	c.(1402-1404)ATC>GTC	p.I468V		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1018					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TTGAGGTCGATCACCGCGTAC	0.537													0	0	0	0.01441	0	97	89										C	36898029	T	C	36898029	3	2	55	1	0	0	0	0	1	0	0	0	16451	1435	50	5	5773	5	TRANK1	3	36898029	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	9571903	36898029	161124401	76	15970										
XYLB	9942	broad.mit.edu	37	chr3	38442474	38442474	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccccaagcccgggagcttctCaggtgagagaccatcggaat	12	13	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:38442474C>A	uc003cic.2	+	18	1640	c.1531C>A	c.(1531-1533)CAG>AAG	p.Q511K	XYLB_uc011ayp.1_Missense_Mutation_p.Q374K|XYLB_uc003cid.1_Missense_Mutation_p.Q433K	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	511					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		GGGAGCTTCTCAGGTGAGAGA	0.493													1	0	6.70999e-13	0.019004	7.66855e-13	37	54										A	38442474	C	A	38442474	3	1	55	1	0	0	0	0	1	0	0	0	17459	827	29	3	1601	3	XYLB	3	38442474	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1544445	38442474	159579956	77	15971										
ANO10	55129	broad.mit.edu	37	chr3	43408465	43408465	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctcggtcacgagcttcattTgctgttaagagaaaacagga	10	8	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:43408465T>G	uc003cmv.2	-	13	2087	c.1916A>C	c.(1915-1917)CAA>CCA	p.Q639P	ANO10_uc011azs.1_3'UTR|ANO10_uc003cmw.2_Missense_Mutation_p.Q573P|ANO10_uc010hil.2_Missense_Mutation_p.Q449P|ANO10_uc011azt.1_Missense_Mutation_p.Q528P	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	639	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						GAGCTTCATTTGCTGTTAAGA	0.577													0	0	0	0.014758	0	4	13										G	43408465	T	G	43408465	3	3	55	1	0	0	0	0	1	0	0	0	696	1826	63	5	70	5	ANO10	3	43408465	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	4965991	43408465	154613965	78	15972										
SETD2	29072	broad.mit.edu	37	chr3	47162291	47162291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttgtgtccaccacaagctcCatagctactgtcaggttgct	8	13	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:47162291C>T	uc003cqs.2	-	3	3888	c.3835G>A	c.(3835-3837)GGA>AGA	p.G1279R	SETD2_uc003cqv.2_Missense_Mutation_p.G1268R	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CCACAAGCTCCATAGCTACTG	0.473			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.004656	0	24	50										T	47162291	C	T	47162291	3	4	55	1	0	0	0	0	1	0	0	0	14131	603	21	2	3935	2	SETD2	3	47162291	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	3753826	47162291	150860139	79	15973										
PLXNB1	5364	broad.mit.edu	37	chr3	48463746	48463746	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgcctggcactcactgtgctCtgggtcatgacatacaggtg	12	11	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:48463746C>T	uc003csw.2	-	5	1683	c.1413G>A	c.(1411-1413)CAG>CAA	p.Q471Q	PLXNB1_uc003csu.2_Silent_p.Q471Q|PLXNB1_uc003csx.2_Silent_p.Q471Q|PLXNB1_uc010hjx.1_RNA	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	471	Extracellular (Potential).|Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCACTGTGCTCTGGGTCATGA	0.597													0	0	0	0.001168	0	5	17										T	48463746	C	T	48463746	2	4	55	1	0	0	0	0	0	0	0	1	12123	912	32	1		1	PLXNB1	3	48463746	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1301455	48463746	149558684	80	15974										
BSN	8927	broad.mit.edu	37	chr3	49694316	49694316	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcaatttgcactgcagcggGaacagctagcgcagcagcgt	12	12	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:49694316G>A	uc003cxe.3	+	5	7441	c.7327G>A	c.(7327-7329)GAA>AAA	p.E2443K		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2443	Potential.				synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ACTGCAGCGGGAACAGCTAGC	0.358													0	0	0	0.00308	0	8	5										A	49694316	G	A	49694316	3	1	55	1	0	0	0	0	1	0	0	0	1530	1175	41	1	7345	1	BSN	3	49694316	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1230570	49694316	148328114	81	15975										
ZMYND10	51364	broad.mit.edu	37	chr3	50379288	50379288	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctgaggggctgaacacatgCtggagctggtgcttggcaat	15	8	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:50379288C>T	uc003dag.1	-	10	1220	c.1074G>A	c.(1072-1074)CAG>CAA	p.Q358Q	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Silent_p.Q353Q|ZMYND10_uc003dah.1_Silent_p.Q279Q	NM_015896	NP_056980	O75800	ZMY10_HUMAN	zinc finger, MYND domain-containing 10	358						cytoplasm	protein binding|zinc ion binding			lung(4)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGAACACATGCTGGAGCTGGT	0.597										TSP Lung(30;0.18)			0	0	0	0.017118	0	36	32										T	50379288	C	T	50379288	2	4	55	1	0	0	0	0	0	0	0	1	17702	796	28	2		2	ZMYND10	3	50379288	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	684972	50379288	147643142	82	15976										
DNAH1	25981	broad.mit.edu	37	chr3	52404221	52404221	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcaagctgctggactgcttCttcaagccctttctgcctag	8	14	4	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:52404221C>T	uc011bef.1	+	39	6495	c.6234C>T	c.(6232-6234)TTC>TTT	p.F2078F		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2078					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGGACTGCTTCTTCAAGCCCT	0.572													0	0	0	0.020292	0	14	27										T	52404221	C	T	52404221	2	4	55	1	0	0	0	0	0	0	0	1	4597	912	32	1		1	DNAH1	3	52404221	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2024933	52404221	145618209	83	15977										
C3orf63	23272	broad.mit.edu	37	chr3	56659005	56659005	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctgatagacattcagaagcGtcaacagacttagagcttta	8	8	3	5			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:56659005G>C	uc003did.3	-	21	4087	c.3986C>G	c.(3985-3987)ACG>AGG	p.T1329R	C3orf63_uc003dib.3_Missense_Mutation_p.T448R|C3orf63_uc003dic.3_Missense_Mutation_p.T953R|C3orf63_uc003die.3_Missense_Mutation_p.T1390R	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1390										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		ATTCAGAAGCGTCAACAGACT	0.348													0	0	0	0.00308	0	6	60										C	56659005	G	C	56659005	3	2	55	1	0	0	0	0	1	0	0	0	2239	1145	40	4	915	4	C3orf63	3	56659005	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4254784	56659005	141363425	84	15978										
DNASE1L3	1776	broad.mit.edu	37	chr3	58178462	58178462	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttagagtgacagattttttGctgttggtgaaggcccttga	12	6	0	5			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:58178462G>A	uc003djo.1	-	8	967	c.870C>T	c.(868-870)AGC>AGT	p.S290S	DNASE1L3_uc011bfd.1_Silent_p.S260S|DNASE1L3_uc003djp.1_Silent_p.S290S|DNASE1L3_uc003djq.1_3'UTR	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	290					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		CAGATTTTTTGCTGTTGGTGA	0.423													0	0	0	0.008361	0	30	82										A	58178462	G	A	58178462	2	1	55	1	0	0	0	0	0	0	0	1	4663	1310	46	2		2	DNASE1L3	3	58178462	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1519457	58178462	139843968	85	15979										
CRYBG3	131544	broad.mit.edu	37	chr3	97661173	97661173	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttggtggccgggacacacctGgagctaaagtagctctatgg	14	9	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:97661173G>A	uc003drx.2	+	18	2930	c.2866G>A	c.(2866-2868)GGA>AGA	p.G956R	CRYBG3_uc010hoz.1_RNA|MINA_uc003dry.1_3'UTR|MINA_uc003drz.1_3'UTR|MINA_uc003dsa.1_3'UTR|MINA_uc003dsb.1_3'UTR|MINA_uc003dsc.1_3'UTR	NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						GGACACACCTGGAGCTAAAGT	0.413													0	0	0	0.008871	0	20	48										A	97661173	G	A	97661173	3	1	55	1	0	0	0	0	1	0	0	0	3913	1349	47	2	2936	2	CRYBG3	3	97661173	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	39482711	97661173	100361257	86	15980										
FAM55C	91775	broad.mit.edu	37	chr3	101540311	101540311	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttccttgcagtggaccagaAgcacaacatcctgctcaaat	7	13	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:101540311A>G	uc003dvn.2	+	8	1830	c.1193A>G	c.(1192-1194)AAG>AGG	p.K398R	FAM55C_uc010hpn.2_Missense_Mutation_p.K398R	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	398						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GTGGACCAGAAGCACAACATC	0.468													0	0	0	0.010729	0	12	24										G	101540311	A	G	101540311	3	3	55	1	0	0	0	0	1	0	0	0	5586	72	3	5	1211	5	FAM55C	3	101540311	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	3879138	101540311	96482119	87	15981										
DZIP3	9666	broad.mit.edu	37	chr3	108343354	108343354	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tatatggagtagcactcactGaaagaggaaagaaagaggta	12	4	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:108343354G>A	uc003dxd.2	+	6	861	c.439G>A	c.(439-441)GAA>AAA	p.E147K	DZIP3_uc003dxf.1_Missense_Mutation_p.E147K|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Missense_Mutation_p.E147K	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	147					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGCACTCACTGAAAGAGGAAA	0.279													0	0	0	0.013537	0	12	33										A	108343354	G	A	108343354	3	1	55	1	0	0	0	0	1	0	0	0	4865	1291	45	1	457	1	DZIP3	3	108343354	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6803043	108343354	89679076	88	15982										
GOLGB1	2804	broad.mit.edu	37	chr3	121413222	121413222	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttcagtttgaacaaattctaGagctttaacagttctctcca	5	9	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:121413222G>A	uc003eei.3	-	13	6259	c.6133C>T	c.(6133-6135)CTA>TTA	p.L2045L	GOLGB1_uc010hrc.2_Silent_p.L2050L|GOLGB1_uc003eej.3_Silent_p.L2011L|GOLGB1_uc011bjm.1_Silent_p.L1931L|GOLGB1_uc010hrd.1_Silent_p.L2009L	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2045	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		ACAAATTCTAGAGCTTTAACA	0.373													0	0	0	0.01441	0	56	24										A	121413222	G	A	121413222	2	1	55	1	0	0	0	0	0	0	0	1	6565	933	33	1		1	GOLGB1	3	121413222	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	13069868	121413222	76609208	89	15983										
PDIA5	10954	broad.mit.edu	37	chr3	122865069	122865069	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agaaatacgcagtgcctgtgCtcaggacaaagaagaagttt	11	7	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:122865069C>T	uc003egc.1	+	13	1161	c.1105C>T	c.(1105-1107)CTC>TTC	p.L369F	PDIA5_uc003egd.1_RNA	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	369	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		AGTGCCTGTGCTCAGGACAAA	0.483													0	0	0	0.013537	0	12	75										T	122865069	C	T	122865069	3	4	55	1	0	0	0	0	1	0	0	0	11671	797	28	2	1155	2	PDIA5	3	122865069	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1451847	122865069	75157361	90	15984										
SLCO2A1	6578	broad.mit.edu	37	chr3	133667440	133667440	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttctccaggaacttgttgaGgaaggtggagaggccagcaa	14	8	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:133667440G>A	uc003eqa.3	-	8	1319	c.1045C>T	c.(1045-1047)CTC>TTC	p.L349F	SLCO2A1_uc003eqb.3_Missense_Mutation_p.L273F|SLCO2A1_uc011blv.1_Missense_Mutation_p.L168F	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	349	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						AACTTGTTGAGGAAGGTGGAG	0.572													0	0	0	0.009096	0	4	169										A	133667440	G	A	133667440	3	1	55	1	0	0	0	0	1	0	0	0	14726	1000	35	2	914	2	SLCO2A1	3	133667440	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	10802371	133667440	64354990	91	15985										
AADAC	13	broad.mit.edu	37	chr3	151545957	151545957	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagtggctaaaggaaaatctAtagtaaaacatgtagctata	9	4	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:151545957A>G	uc003eze.2	+	5	1287	c.1197A>G	c.(1195-1197)CTA>CTG	p.L399L		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	399	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AGGAAAATCTATAGTAAAACA	0.299													0	0	0	0.014323	0	24	12										G	151545957	A	G	151545957	2	3	55	1	0	0	0	0	0	0	0	1	10	436	16	5		5	AADAC	3	151545957	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	17878517	151545957	46476473	92	15986										
SCHIP1	29970	broad.mit.edu	37	chr3	159482390	159482390	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctggacttggtgtctgccctGgaggactatgaggagccctt	14	10	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:159482390G>A	uc003fcs.1	+	2	288	c.222G>A	c.(220-222)CTG>CTA	p.L74L	SCHIP1_uc003fcq.1_Silent_p.L150L|SCHIP1_uc003fcr.1_Silent_p.L63L|SCHIP1_uc003fct.1_Silent_p.L74L|SCHIP1_uc010hvz.1_Silent_p.L47L	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	74						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			TGTCTGCCCTGGAGGACTATG	0.493													0	0	0	0.001984	0	6	4										A	159482390	G	A	159482390	2	1	55	1	0	0	0	0	0	0	0	1	13904	1335	47	2		2	SCHIP1	3	159482390	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	7936433	159482390	38540040	93	15987										
NLGN1	22871	broad.mit.edu	37	chr3	173996714	173996714	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagctgggctgttagttttcAacctgcaaaatatgctagaa	9	8	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:173996714A>T	uc003fio.1	+	6	1346	c.923A>T	c.(922-924)CAA>CTA	p.Q308L	NLGN1_uc010hww.1_Missense_Mutation_p.Q348L|NLGN1_uc003fip.1_Missense_Mutation_p.Q308L	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	325	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GTTAGTTTTCAACCTGCAAAA	0.388													0	0	0	0.013537	0	11	23										T	173996714	A	T	173996714	3	4	55	1	0	0	0	0	1	0	0	0	10461	130	5	5	937	5	NLGN1	3	173996714	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	14514324	173996714	24025716	94	15988										
EIF4G1	1981	broad.mit.edu	37	chr3	184040229	184040229	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gttggagaccttctggatgcCttcaaggaggtaagggagca	15	7	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr3:184040229C>T	uc003fnp.2	+	11	1797	c.1599C>T	c.(1597-1599)GCC>GCT	p.A533A	EIF4G1_uc003fno.1_Silent_p.A474A|EIF4G1_uc010hxw.1_Silent_p.A369A|EIF4G1_uc003fnt.2_Silent_p.A244A|EIF4G1_uc003fnq.2_Silent_p.A446A|EIF4G1_uc003fnr.2_Silent_p.A369A|EIF4G1_uc010hxx.2_Silent_p.A540A|EIF4G1_uc003fns.2_Silent_p.A493A|EIF4G1_uc010hxy.2_Silent_p.A540A|EIF4G1_uc003fnv.3_Silent_p.A533A|EIF4G1_uc003fnu.3_Silent_p.A533A|EIF4G1_uc003fnw.2_Silent_p.A540A|EIF4G1_uc003fnx.2_Silent_p.A337A|EIF4G1_uc003fny.3_Silent_p.A337A	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	533					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCTGGATGCCTTCAAGGAGG	0.438													0	0	0	0.006214	0	8	21										T	184040229	C	T	184040229	2	4	55	1	0	0	0	0	0	0	0	1	5036	668	24	2		2	EIF4G1	3	184040229	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	10043515	184040229	13982201	95	15989										
ZNF721	170960	broad.mit.edu	37	chr4	436514	436514	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cacatttgtaaggtttctctCcagtatgaattctcctatgt	6	9	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:436514C>G	uc003gag.2	-	3	2433	c.1742G>C	c.(1741-1743)GGA>GCA	p.G581A	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.G613A|ZNF721_uc010ibe.2_Missense_Mutation_p.G569A	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	581						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGGTTTCTCTCCAGTATGAAT	0.398													0	0	0	0.00632	0	27	123										G	436514	C	G	436514	3	3	55	1	0	0	0	0	1	0	0	0	18119	855	30	1	1033	1	ZNF721	4	436514	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		436514	190717762	96	15990										
ADD1	118	broad.mit.edu	37	chr4	2927796	2927796	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agtcctccagaccagcctgcGgtcccccacccgcctcccag	8	22	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:2927796G>T	uc003gfr.2	+	14	2006	c.1818G>T	c.(1816-1818)GCG>GCT	p.A606A	ADD1_uc003gfn.2_Intron|ADD1_uc003gfo.2_Silent_p.A637A|ADD1_uc003gfp.2_Silent_p.A606A|ADD1_uc003gfq.2_Silent_p.A637A|ADD1_uc003gfs.2_Silent_p.A637A	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	606				A -> E (in Ref. 2; AAB05645).	actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACCAGCCTGCGGTCCCCCACC	0.622													1	0	6.40141e-05	0.010729	7.02399e-05	10	45										T	2927796	G	T	2927796	2	4	55	1	0	0	0	0	0	0	0	1	304	1103	39	4		4	ADD1	4	2927796	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2491282	2927796	188226480	97	15991										
TADA2B	93624	broad.mit.edu	37	chr4	7045505	7045505	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgctctgggggcccgaggccGagggcggctggaccagtcgc	19	14	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:7045505G>A	uc003gjw.3	+	1	350	c.199G>A	c.(199-201)GAG>AAG	p.E67K	CCDC96_uc003gjv.2_5'Flank|TADA2B_uc010idi.2_Intron	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	67	SANT.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GCCCGAGGCCGAGGGCGGCTG	0.736													0	0	0	0.014758	0	4	18										A	7045505	G	A	7045505	3	1	55	1	0	0	0	0	1	0	0	0	15508	1059	37	1	201	1	TADA2B	4	7045505	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4117709	7045505	184108771	98	15992										
TLR10	81793	broad.mit.edu	37	chr4	38776079	38776079	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccagtttattgccattcaaaAtgagagttttcaagtgaggc	9	7	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:38776079A>T	uc003gti.2	-	2	1512	c.1133T>A	c.(1132-1134)ATT>AAT	p.I378N	TLR10_uc003gtj.2_Missense_Mutation_p.I378N|TLR10_uc003gtk.2_Missense_Mutation_p.I378N	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	378	Extracellular (Potential).|LRR 10.				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						GCCATTCAAAATGAGAGTTTT	0.328													0	0	0	0.016522	0	24	37										T	38776079	A	T	38776079	3	4	55	1	0	0	0	0	1	0	0	0	15947	101	4	5	1306	5	TLR10	4	38776079	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	31730574	38776079	152378197	99	15993										
TLR10	81793	broad.mit.edu	37	chr4	38776209	38776209	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	catgtgtggcatttgtgcatTtgatattgtcaggttttcta	10	5	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:38776209T>G	uc003gti.2	-	2	1382	c.1003A>C	c.(1003-1005)AAT>CAT	p.N335H	TLR10_uc003gtj.2_Missense_Mutation_p.N335H|TLR10_uc003gtk.2_Missense_Mutation_p.N335H	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	335	LRR 8.|Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						ATTTGTGCATTTGATATTGTC	0.308													0	0	0	0.012319	0	22	20										G	38776209	T	G	38776209	3	3	55	1	0	0	0	0	1	0	0	0	15947	1841	64	5	1436	5	TLR10	4	38776209	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	130	38776209	152378067	100	15994										
N4BP2	55728	broad.mit.edu	37	chr4	40146392	40146392	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gatgaagctctagaacatttGatgagagttttagagaagaa	11	3	1	6			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:40146392G>C	uc003guy.3	+	16	5453	c.5115G>C	c.(5113-5115)TTG>TTC	p.L1705F	N4BP2_uc010ifq.2_Missense_Mutation_p.L1625F|N4BP2_uc010ifr.2_Missense_Mutation_p.L1608F	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1705	Smr.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TAGAACATTTGATGAGAGTTT	0.393													0	0	0	0.008291	0	10	27										C	40146392	G	C	40146392	3	2	55	1	0	0	0	0	1	0	0	0	10110	1281	45	1	5169	1	N4BP2	4	40146392	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1370183	40146392	151007884	101	15995										
GUF1	60558	broad.mit.edu	37	chr4	44693709	44693709	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agagcagttcagaagaatatGatatttattgatcaaaatag	8	3	2	5			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:44693709G>A	uc003gww.3	+	13	1713	c.1506G>A	c.(1504-1506)ATG>ATA	p.M502I		NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	502					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						AGAAGAATATGATATTTATTG	0.313													0	0	0	0.021523	0	26	43										A	44693709	G	A	44693709	3	1	55	1	0	0	0	0	1	0	0	0	6899	1290	45	1	1556	1	GUF1	4	44693709	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4547317	44693709	146460567	102	15996										
TEC	7006	broad.mit.edu	37	chr4	48140938	48140938	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	taccaaatgaccagacatctGatttgctgctgaagcggctg	10	10	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:48140938G>A	uc003gxz.2	-	16	1728	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	546	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						CCAGACATCTGATTTGCTGCT	0.443													0	0	0	0.006122	0	17	21										A	48140938	G	A	48140938	3	1	55	1	0	0	0	0	1	0	0	0	15739	1294	45	1	270	1	TEC	4	48140938	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3447229	48140938	143013338	103	15997										
SCFD2	152579	broad.mit.edu	37	chr4	54231440	54231440	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaatgttcacacagagaactGaggcctgacactaggcatct	9	10	2	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:54231440G>A	uc003gzu.2	-	1	803	c.669C>T	c.(667-669)CTC>CTT	p.L223L	SCFD2_uc010igm.2_Silent_p.L223L	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	223					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ACAGAGAACTGAGGCCTGACA	0.547													0	0	0	0.004482	0	9	31										A	54231440	G	A	54231440	2	1	55	1	0	0	0	0	0	0	0	1	13890	1277	45	1		1	SCFD2	4	54231440	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6090502	54231440	136922836	104	15998										
GSX2	170825	broad.mit.edu	37	chr4	54967810	54967810	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aggacggcgttcactagcacGcaactcctggagctggagag	14	11	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:54967810G>T	uc010igp.1	+	2	900	c.636G>T	c.(634-636)ACG>ACT	p.T212T	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	212	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			TCACTAGCACGCAACTCCTGG	0.572													1	0	2.12542e-12	0.00632	2.41649e-12	29	34										T	54967810	G	T	54967810	2	4	55	1	0	0	0	0	0	0	0	1	6850	1074	38	4		4	GSX2	4	54967810	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	736370	54967810	136186466	105	15999										
UGT2B4	7363	broad.mit.edu	37	chr4	70361469	70361469	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tccaggattgtctttatattCatccagtggctgaattctgt	8	8	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:70361469C>T	uc003hek.3	-	1	158	c.111G>A	c.(109-111)ATG>ATA	p.M37I	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.M37I	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	37					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TCTTTATATTCATCCAGTGGC	0.468													0	0	0	0.021022	0	36	71										T	70361469	C	T	70361469	3	4	55	1	0	0	0	0	1	0	0	0	16958	826	29	1	1499	1	UGT2B4	4	70361469	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	15393659	70361469	120792807	106	16000										
DCK	1633	broad.mit.edu	37	chr4	71863897	71863897	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaagtactcaagatgaatttGaggtatgaaaataaaattta	7	2	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:71863897G>A	uc003hfx.2	+	2	493	c.205G>A	c.(205-207)GAG>AAG	p.E69K	DCK_uc011cbb.1_5'UTR	NM_000788	NP_000779	P27707	DCK_HUMAN	deoxycytidine kinase	69					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	AGATGAATTTGAGGTATGAAA	0.318													0	0	0	0.014323	0	21	28										A	71863897	G	A	71863897	3	1	55	1	0	0	0	0	1	0	0	0	4290	1291	45	1	211	1	DCK	4	71863897	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1502428	71863897	119290379	107	16001										
BMP2K	55589	broad.mit.edu	37	chr4	79833000	79833000	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgatcacaatactgtcctgcCagggcggccaagacaaaatt	9	11	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:79833000C>A	uc003hlk.2	+	16	3465	c.3299C>A	c.(3298-3300)CCA>CAA	p.P1100Q	PAQR3_uc003hlm.2_Intron|PAQR3_uc003hln.2_Intron|uc010ijm.1_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	1100						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						ACTGTCCTGCCAGGGCGGCCA	0.522													1	0	1.22384e-17	0.013726	1.42081e-17	35	50										A	79833000	C	A	79833000	3	1	55	1	0	0	0	0	1	0	0	0	1460	594	21	4	3399	4	BMP2K	4	79833000	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	7969103	79833000	111321276	108	16002										
ADH1B	125	broad.mit.edu	37	chr4	100237199	100237199	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagaaggtgctggtgccaagGaagtggtgaatgggcttccc	17	7	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:100237199G>A	uc003hus.3	-	5	507	c.423C>T	c.(421-423)TTC>TTT	p.F141F	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Silent_p.F101F|ADH1B_uc011ceh.1_Intron|ADH1B_uc011cei.1_Silent_p.F101F	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	141					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TGGTGCCAAGGAAGTGGTGAA	0.577													0	0	0	0.01892	0	26	46										A	100237199	G	A	100237199	2	1	55	1	0	0	0	0	0	0	0	1	308	1165	41	1		1	ADH1B	4	100237199	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	20404199	100237199	90917077	109	16003										
C4orf29	80167	broad.mit.edu	37	chr4	128930328	128930328	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aagcccgaatggcttctttaTtgttagaaaacccttattat	6	8	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:128930328T>A	uc003ifr.2	+	6	742	c.424T>A	c.(424-426)TTG>ATG	p.L142M	C4orf29_uc003ifq.1_RNA|C4orf29_uc003ifs.2_Missense_Mutation_p.L15M|C4orf29_uc003ift.2_5'Flank|C4orf29_uc003ifu.2_5'Flank|C4orf29_uc010inz.2_5'Flank|C4orf29_uc003ifv.2_5'Flank	NM_001039717	NP_001034806	Q0P651	CD029_HUMAN	hypothetical protein LOC80167 precursor	142						extracellular region				ovary(1)	1						GGCTTCTTTATTGTTAGAAAA	0.333													0	0	0	0.004482	0	7	11										A	128930328	T	A	128930328	3	1	55	1	0	0	0	0	1	0	0	0	2259	1490	52	5	442	5	C4orf29	4	128930328	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	28693129	128930328	62223948	110	16004										
USP38	84640	broad.mit.edu	37	chr4	144135055	144135055	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcatcacccagtatacaagaTggtggtctaatgcaagcctc	8	11	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:144135055T>G	uc003ijb.2	+	9	2460	c.1926T>G	c.(1924-1926)GAT>GAG	p.D642E	USP38_uc003ija.3_Missense_Mutation_p.D642E|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	642					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					GTATACAAGATGGTGGTCTAA	0.438													0	0	0	0.01441	0	56	124										G	144135055	T	G	144135055	3	3	55	1	0	0	0	0	1	0	0	0	17066	1461	51	5	1960	5	USP38	4	144135055	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	15204727	144135055	47019221	111	16005										
TMEM154	201799	broad.mit.edu	37	chr4	153573937	153573937	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aactctaactgattttcatcCggagcaaagttggtagaatt	8	7	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:153573937C>A	uc003imw.1	-	2	313	c.207G>T	c.(205-207)CCG>CCT	p.P69P		NM_152680	NP_689893	Q6P9G4	TM154_HUMAN	transmembrane protein 154 precursor	69	Extracellular (Potential).					integral to membrane					0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				GATTTTCATCCGGAGCAAAGT	0.333													1	0	7.03913e-09	0.013537	7.90106e-09	10	34										A	153573937	C	A	153573937	2	1	55	1	0	0	0	0	0	0	0	1	16068	639	23	4		4	TMEM154	4	153573937	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	9438882	153573937	37580339	112	16006										
FAM198B	51313	broad.mit.edu	37	chr4	159092463	159092463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgctccagagcttacgcaccCgcgggacgcacagggagcag	14	14	0	1	rs148186776		TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:159092463C>T	uc003ipp.3	-	2	517	c.65G>A	c.(64-66)CGG>CAG	p.R22Q	uc003ipu.1_5'Flank|FAM198B_uc003ipq.3_Missense_Mutation_p.R22Q|FAM198B_uc003ipr.3_Missense_Mutation_p.R22Q|FAM198B_uc003ips.2_Missense_Mutation_p.R22Q|uc003ipt.1_RNA	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	22	Cytoplasmic (Potential).					Golgi membrane|integral to membrane					0						CTTACGCACCCGCGGGACGCA	0.587													0	0	0	0.003163	0	12	39										T	159092463	C	T	159092463	3	4	55	1	0	0	0	0	1	0	0	0	5529	652	23	2	1615	2	FAM198B	4	159092463	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5518526	159092463	32061813	113	16007										
SH3RF1	57630	broad.mit.edu	37	chr4	170028077	170028077	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcgaggaggtggagcgatggGaactgcggagtccagggaac	20	7	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:170028077G>A	uc003isa.1	-	11	2754	c.2419C>T	c.(2419-2421)CCC>TCC	p.P807S		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	807						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		GGAGCGATGGGAACTGCGGAG	0.587													0	0	0	0.007291	0	30	45										A	170028077	G	A	170028077	3	1	55	1	0	0	0	0	1	0	0	0	14258	1174	41	1	255	1	SH3RF1	4	170028077	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	10935614	170028077	21126199	114	16008										
SH3RF1	57630	broad.mit.edu	37	chr4	170028181	170028181	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgtccccgtccacagggcagGagcctgccctgccatggcca	12	18	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr4:170028181G>T	uc003isa.1	-	11	2650	c.2315C>A	c.(2314-2316)TCC>TAC	p.S772Y		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	772						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CACAGGGCAGGAGCCTGCCCT	0.662													1	0	2.17888e-05	0.006214	2.41488e-05	7	21										T	170028181	G	T	170028181	3	4	55	1	0	0	0	0	1	0	0	0	14258	1174	41	3	359	3	SH3RF1	4	170028181	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	104	170028181	21126095	115	16009										
SDHA	6389	broad.mit.edu	37	chr5	235398	235398	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcacgaaggagccgatccctGtcctccccaccgtgcattat	8	16	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:235398G>C	uc003jao.3	+	9	1319	c.1204G>C	c.(1204-1206)GTC>CTC	p.V402L	SDHA_uc003jan.2_Missense_Mutation_p.V402L|SDHA_uc011clv.1_Missense_Mutation_p.V402L|SDHA_uc011clw.1_Missense_Mutation_p.V354L|SDHA_uc003jap.3_Missense_Mutation_p.V402L|SDHA_uc003jaq.3_Missense_Mutation_p.V177L|SDHA_uc003jar.3_Intron	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	402					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	GCCGATCCCTGTCCTCCCCAC	0.617									Familial_Paragangliomas				0	0	0	0.012319	0	18	60										C	235398	G	C	235398	3	2	55	1	0	0	0	0	1	0	0	0	13963	1377	48	4	1238	4	SDHA	5	235398	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		235398	180679862	116	16010										
FASTKD3	79072	broad.mit.edu	37	chr5	7861273	7861273	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaaccgtacctgaacaacttGataaccgagtaactgtaggt	8	9	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:7861273G>C	uc003jeb.2	-	6	2010	c.1873C>G	c.(1873-1875)CAA>GAA	p.Q625E	FASTKD3_uc011cmp.1_Missense_Mutation_p.Q327E|FASTKD3_uc003jec.2_RNA	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	625	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TGAACAACTTGATAACCGAGT	0.323													0	0	0	0.010504	0	21	48										C	7861273	G	C	7861273	3	2	55	1	0	0	0	0	1	0	0	0	5687	1299	45	1	123	1	FASTKD3	5	7861273	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	7625875	7861273	173053987	117	16011										
SEMA5A	9037	broad.mit.edu	37	chr5	9063097	9063097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggttgttgcaaacacgcttcCggttccgaatgcccctgctg	11	13	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:9063097C>T	uc003jek.2	-	18	3132	c.2420G>A	c.(2419-2421)CGG>CAG	p.R807Q		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	807	TSP type-1 5.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AACACGCTTCCGGTTCCGAAT	0.592													0	0	0	0.004482	0	8	39										T	9063097	C	T	9063097	3	4	55	1	0	0	0	0	1	0	0	0	14037	652	23	2	828	2	SEMA5A	5	9063097	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1201824	9063097	171852163	118	16012										
PRDM9	56979	broad.mit.edu	37	chr5	23526685	23526685	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaaaaagaataatggaagaAgagtccagaacaggccagaa	12	5	0	5			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:23526685A>C	uc003jgo.2	+	11	1670	c.1488A>C	c.(1486-1488)GAA>GAC	p.E496D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	496					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TAATGGAAGAAGAGTCCAGAA	0.448										HNSCC(3;0.000094)			0	0	0	0.001168	0	6	35										C	23526685	A	C	23526685	3	2	55	1	0	0	0	0	1	0	0	0	12463	69	3	5	1526	5	PRDM9	5	23526685	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	14463588	23526685	157388575	119	16013										
PTGER4	5734	broad.mit.edu	37	chr5	40681893	40681893	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttccgccgcatcgcgggcgcCgagatccagatggtcatctt	12	14	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:40681893C>G	uc003jlz.2	+	2	1390	c.798C>G	c.(796-798)GCC>GCG	p.A266A		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	266	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						TCGCGGGCGCCGAGATCCAGA	0.706													0	0	0	0.001168	0	6	125										G	40681893	C	G	40681893	2	3	55	1	0	0	0	0	0	0	0	1	12745	639	23	4		4	PTGER4	5	40681893	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	17155208	40681893	140233367	120	16014										
ISL1	3670	broad.mit.edu	37	chr5	50687238	50687238	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agtactgagcgacttcgcctTgcagagtgacatagatcagc	11	10	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:50687238T>C	uc003jor.2	+	5	1444	c.896T>C	c.(895-897)TTG>TCG	p.L299S		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	299	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				GACTTCGCCTTGCAGAGTGAC	0.517													0	0	0	0.009718	0	36	80										C	50687238	T	C	50687238	3	2	55	1	0	0	0	0	1	0	0	0	7856	1821	63	5	914	5	ISL1	5	50687238	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	10005345	50687238	130228022	121	16015										
VCAN	1462	broad.mit.edu	37	chr5	82817219	82817219	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaatcacagagggaacaactCaggaagaattcccttggaaa	9	8	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:82817219C>G	uc003kii.3	+	7	3450	c.3094C>G	c.(3094-3096)CAG>GAG	p.Q1032E	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.Q1032E|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1032	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGGAACAACTCAGGAAGAATT	0.453													0	0	0	0.004672	0	2	16										G	82817219	C	G	82817219	3	3	55	1	0	0	0	0	1	0	0	0	17135	827	29	1	3116	1	VCAN	5	82817219	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	32129981	82817219	98098041	122	16016										
WDR36	134430	broad.mit.edu	37	chr5	110445967	110445967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agatgtatataacatgcagtCtggcatacatcgaggaagtt	10	6	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:110445967C>T	uc003kpd.2	+	13	1691	c.1574C>T	c.(1573-1575)TCT>TTT	p.S525F	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	525	WD 6.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		AACATGCAGTCTGGCATACAT	0.358													0	0	0	0.008361	0	29	16										T	110445967	C	T	110445967	3	4	55	1	0	0	0	0	1	0	0	0	17287	913	32	1	1624	1	WDR36	5	110445967	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	27628748	110445967	70469293	123	16017										
TMED7-TICAM2	100302736	broad.mit.edu	37	chr5	114916656	114916656	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gataccaaagtcatcttgtaGcagattctggactctgaggg	11	8	4	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:114916656G>C	uc003krd.2	-	4	1304	c.298C>G	c.(298-300)CTA>GTA	p.L100V	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.L269V|TICAM2_uc003krc.2_Missense_Mutation_p.L100V	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	100	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0						TCATCTTGTAGCAGATTCTGG	0.418													0	0	0	0.014323	0	20	128										C	114916656	G	C	114916656	3	2	55	1	0	0	0	0	1	0	0	0	16007	962	34	4		4	TMED7-TICAM2	5	114916656	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4470689	114916656	65998604	124	16018										
FBN2	2201	broad.mit.edu	37	chr5	127693083	127693083	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gggttgctttcacattcattTatatctacaatccagaagga	7	8	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:127693083T>C	uc003kuu.2	-	20	2998	c.2559A>G	c.(2557-2559)ATA>ATG	p.I853M	FBN2_uc003kuv.2_Missense_Mutation_p.I820M	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	853	EGF-like 13; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CACATTCATTTATATCTACAA	0.423													0	0	0	0.007291	0	29	7										C	127693083	T	C	127693083	3	2	55	1	0	0	0	0	1	0	0	0	5703	1744	61	5	6363	5	FBN2	5	127693083	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	12776427	127693083	53222177	125	16019										
SLC27A6	28965	broad.mit.edu	37	chr5	128324319	128324319	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	caaaagcagctgtgattagtCagctgcaggttttaaggggt	13	6	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:128324319C>G	uc003kuy.2	+	4	1108	c.712C>G	c.(712-714)CAG>GAG	p.Q238E	SLC27A6_uc003kuz.2_Missense_Mutation_p.Q238E	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	238					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TGTGATTAGTCAGCTGCAGGT	0.328													0	0	0	0.01441	0	53	29										G	128324319	C	G	128324319	3	3	55	1	0	0	0	0	1	0	0	0	14530	827	29	1	722	1	SLC27A6	5	128324319	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	631236	128324319	52590941	126	16020										
AFF4	27125	broad.mit.edu	37	chr5	132223670	132223670	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atacagctttctcaaacctaTcagactgaagaaaggagaat	7	8	2	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:132223670T>C	uc003kyd.2	-	16	3209	c.2801A>G	c.(2800-2802)GAT>GGT	p.D934G	AFF4_uc011cxk.1_Missense_Mutation_p.D612G	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	934					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTCAAACCTATCAGACTGAAG	0.348													0	0	0	0.010504	0	20	11										C	132223670	T	C	132223670	3	2	55	1	0	0	0	0	1	0	0	0	359	1435	50	5	714	5	AFF4	5	132223670	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	3899351	132223670	48691590	127	16021										
ZNF300	91975	broad.mit.edu	37	chr5	150275116	150275116	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctgatgtaaaacaaggtctGacttctgagaaaaggccttt	9	7	3	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:150275116G>A	uc003lsy.1	-	6	1952	c.1685C>T	c.(1684-1686)TCA>TTA	p.S562L	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	562	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACAAGGTCTGACTTCTGAGA	0.458													0	0	0	0.015359	0	34	15										A	150275116	G	A	150275116	3	1	55	1	0	0	0	0	1	0	0	0	17828	1294	45	1	133	1	ZNF300	5	150275116	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	18051446	150275116	30640144	128	16022										
F12	2161	broad.mit.edu	37	chr5	176830946	176830946	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgtggccccagtacagcgcGgcgatgtaggggtgcgcccc	16	14	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:176830946G>A	uc003mgo.3	-	10	1213	c.1164C>T	c.(1162-1164)GCC>GCT	p.A388A	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	388	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTACAGCGCGGCGATGTAGG	0.716									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	6										A	176830946	G	A	176830946	2	1	55	1	0	0	0	0	0	0	0	1	5339	1103	39	2		2	F12	5	176830946	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	26555830	176830946	4084314	129	16023										
F12	2161	broad.mit.edu	37	chr5	176831565	176831565	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcagtcacgttccggtaggtGgcctccgaggcccacggctg	15	14	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:176831565G>A	uc003mgo.3	-	8	784	c.735C>T	c.(733-735)GCC>GCT	p.A245A	F12_uc011dfy.1_5'Flank|F12_uc003mgn.3_5'Flank|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	245	Kringle.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCGGTAGGTGGCCTCCGAGG	0.726									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	10	4										A	176831565	G	A	176831565	2	1	55	1	0	0	0	0	0	0	0	1	5339	1335	47	2		2	F12	5	176831565	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	619	176831565	4083695	130	16024										
MAPK9	5601	broad.mit.edu	37	chr5	179696343	179696343	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gctctctttgcatgagtttgGttctgaaaaggacggcttag	12	7	2	2	rs148710250	by1000genomes	TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr5:179696343G>T	uc003mls.3	-	3	460	c.189C>A	c.(187-189)AAC>AAA	p.N63K	MAPK9_uc003mlt.3_Missense_Mutation_p.N63K|MAPK9_uc010jlc.2_Missense_Mutation_p.N63K|MAPK9_uc003mlv.3_Missense_Mutation_p.N63K|MAPK9_uc011dgx.1_Missense_Mutation_p.N63K	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	63	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGAGTTTGGTTCTGAAAAG	0.348													1	0	3.90053e-15	0.012213	4.49275e-15	34	5										T	179696343	G	T	179696343	3	4	55	1	0	0	0	0	1	0	0	0	9287	1252	44	4	1247	4	MAPK9	5	179696343	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2864778	179696343	1218917	131	16025										
PRPF4B	8899	broad.mit.edu	37	chr6	4059021	4059021	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	caaaatctcaacttcatgtaCatagaagttgataaagtaac	5	7	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:4059021C>T	uc003mvv.2	+	14	2884	c.2793C>T	c.(2791-2793)TAC>TAT	p.Y931Y	PRPF4B_uc003mvw.2_RNA|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	931	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ACTTCATGTACATAGAAGTTG	0.313													0	0	0	0.00308	0	8	37										T	4059021	C	T	4059021	2	4	55	1	0	0	0	0	0	0	0	1	12573	489	17	2		2	PRPF4B	6	4059021	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		4059021	167056046	132	16026										
RREB1	6239	broad.mit.edu	37	chr6	7211055	7211055	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agacatatgaagatccatgaGaaggaccctaacagtgccac	9	10	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:7211055G>A	uc003mxc.2	+	7	834	c.444G>A	c.(442-444)GAG>GAA	p.E148E	RREB1_uc010jnw.2_Silent_p.E148E|RREB1_uc003mxb.2_Silent_p.E148E|RREB1_uc010jnx.2_Silent_p.E148E|RREB1_uc003mxd.2_Silent_p.E148E	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	148					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AGATCCATGAGAAGGACCCTA	0.423													0	0	0	0.00632	0	30	70										A	7211055	G	A	7211055	2	1	55	1	0	0	0	0	0	0	0	1	13679	933	33	1		1	RREB1	6	7211055	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3152034	7211055	163904012	133	16027										
PRL	5617	broad.mit.edu	37	chr6	22297250	22297250	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaacacacttcaccagagaaGatctggaagtctcacggttt	8	10	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:22297250G>C	uc003ndp.2	-	1	481	c.-38C>G	c.(-40--36)ATCTT>ATGTT		PRL_uc003ndo.2_Translation_Start_Site|PRL_uc003ndq.2_Translation_Start_Site|PRL_uc003ndr.1_RNA	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor						cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					CACCAGAGAAGATCTGGAAGT	0.408													0	0	0	0.004007	0	16	29										C	22297250	G	C	22297250	1	2	55	1	0	0	0	0	0	0	0	0	12528	957	33	1		1	PRL	6	22297250	Translation_Start_Site	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	15086195	22297250	148817817	134	16028										
GPLD1	2822	broad.mit.edu	37	chr6	24433445	24433445	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gacctcacggtgatgagggaGctcccaaaccttgagctggc	13	12	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:24433445G>A	uc003ned.1	-	24	2517	c.2406C>T	c.(2404-2406)AGC>AGT	p.S802S		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	802	FG-GAP 7.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						TGATGAGGGAGCTCCCAAACC	0.453													0	0	0	0.00499	0	17	163										A	24433445	G	A	24433445	2	1	55	1	0	0	0	0	0	0	0	1	6614	962	34	2		2	GPLD1	6	24433445	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2136195	24433445	146681622	135	16029										
GPLD1	2822	broad.mit.edu	37	chr6	24454389	24454389	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggtgcgcccaccacgaggtCaccgtgcccatcctggttga	12	15	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:24454389C>T	uc003ned.1	-	14	1300	c.1189G>A	c.(1189-1191)GAC>AAC	p.D397N	GPLD1_uc010jpr.1_Missense_Mutation_p.D234N|GPLD1_uc010jps.1_Missense_Mutation_p.D397N	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	397	FG-GAP 1.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						ACCACGAGGTCACCGTGCCCA	0.612													0	0	0	0.008871	0	20	30										T	24454389	C	T	24454389	3	4	55	1	0	0	0	0	1	0	0	0	6614	826	29	1	1381	1	GPLD1	6	24454389	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	20944	24454389	146660678	136	16030										
HIST1H2BI	8346	broad.mit.edu	37	chr6	26273432	26273432	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttttcgagcgcattgcaggcGaggcttcccgcctggcgcat	13	13	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:26273432G>A	uc003nhk.2	+	1	229	c.229G>A	c.(229-231)GAG>AAG	p.E77K	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	77					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CATTGCAGGCGAGGCTTCCCG	0.587													0	0	0	0.010818	0	32	111										A	26273432	G	A	26273432	3	1	55	1	0	0	0	0	1	0	0	0	7148	1059	37	1	231	1	HIST1H2BI	6	26273432	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1819043	26273432	144841635	137	16031										
ZFP57	346171	broad.mit.edu	37	chr6	29641397	29641397	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cctgggatgcttgaagcaccCgggtcctgtccatagtccca	11	14	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:29641397C>A	uc011dlw.1	-	4	642	c.491G>T	c.(490-492)CGG>CTG	p.R164L	ZFP57_uc003nnl.3_Missense_Mutation_p.R144L	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	80	KRAB.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTGAAGCACCCGGGTCCTGTC	0.572													1	0	5.50884e-06	0.013537	6.12093e-06	13	187										A	29641397	C	A	29641397	3	1	55	1	0	0	0	0	1	0	0	0	17648	652	23	4	1123	4	ZFP57	6	29641397	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	3367965	29641397	141473670	138	16032										
BAT5	7920	broad.mit.edu	37	chr6	31668761	31668761	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagaagtagcagcaatgtccCagcatagtgagaaaacggca	11	9	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:31668761C>G	uc003nvy.1	-	4	331	c.301G>C	c.(301-303)GGG>CGG	p.G101R	BAT5_uc003nvx.1_5'UTR|BAT5_uc011dny.1_Missense_Mutation_p.G68R|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_5'UTR|BAT5_uc010jtc.1_RNA|BAT5_uc011doa.1_Silent_p.L2L	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	101	Helical; (Potential).					integral to membrane	hydrolase activity|protein binding				0						AGCAATGTCCCAGCATAGTGA	0.507													0	0	0	0.013537	0	11	60										G	31668761	C	G	31668761	3	3	55	1	0	0	0	0	1	0	0	0	1324	594	21	4	1443	4	BAT5	6	31668761	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2027364	31668761	139446306	139	16033										
FKBP5	2289	broad.mit.edu	37	chr6	35588041	35588041	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	accccaatgtcccatgccttGatgacttggcctaagggaaa	9	12	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:35588041G>C	uc011dte.1	-	4	464	c.261C>G	c.(259-261)ATC>ATG	p.I87M	FKBP5_uc003okx.2_Missense_Mutation_p.I87M|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Missense_Mutation_p.I87M|FKBP5_uc003okz.2_Missense_Mutation_p.I87M	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	87	PPIase FKBP-type 1.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						CCCATGCCTTGATGACTTGGC	0.403													0	0	0	0.009718	0	40	41										C	35588041	G	C	35588041	3	2	55	1	0	0	0	0	1	0	0	0	5911	1280	45	1	1202	1	FKBP5	6	35588041	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3919280	35588041	135527026	140	16034										
CCND3	896	broad.mit.edu	37	chr6	41908297	41908297	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atggccagggggaagacttcCtcctcacagcgctgctcctc	11	15	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:41908297C>G	uc003orn.2	-	2	390	c.225G>C	c.(223-225)GAG>GAC	p.E75D	CCND3_uc003orp.2_5'UTR|CCND3_uc011duk.1_Intron|CCND3_uc011dum.1_5'UTR|CCND3_uc003orm.2_Missense_Mutation_p.E25D|CCND3_uc003oro.2_Intron|CCND3_uc011dul.1_Intron	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	75	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGAAGACTTCCTCCTCACAGC	0.647			T	IGH@	MM								0	0	0	0.005524	0	37	38										G	41908297	C	G	41908297	3	3	55	1	0	0	0	0	1	0	0	0	2918	680	24	4	669	4	CCND3	6	41908297	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	6320256	41908297	129206770	141	16035										
KLHDC3	116138	broad.mit.edu	37	chr6	42985893	42985893	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcctactcaggcggactgttTttccaatgacattcacaagc	7	12	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:42985893T>G	uc003otl.2	+	5	627	c.458T>G	c.(457-459)TTT>TGT	p.F153C	KLHDC3_uc003otm.2_RNA|KLHDC3_uc010jyf.2_Intron|KLHDC3_uc003otn.2_Missense_Mutation_p.F37C|KLHDC3_uc003oto.2_Missense_Mutation_p.F94C	NM_057161	NP_476502	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	153	Kelch 3.				reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			upper_aerodigestive_tract(1)	1			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCGGACTGTTTTTCCAATGAC	0.473													0	0	0	0.01441	0	62	38										G	42985893	T	G	42985893	3	3	55	1	0	0	0	0	1	0	0	0	8357	1841	64	5	472	5	KLHDC3	6	42985893	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	1077596	42985893	128129174	142	16036										
SLC29A1	2030	broad.mit.edu	37	chr6	44201158	44201158	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttccttccccgcttaggaaaGtgaagccagctgaggcagag	12	11	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:44201158G>C	uc003owu.1	+	13	1593	c.1264G>C	c.(1264-1266)GTG>CTG	p.V422L	SLC29A1_uc003owv.1_Missense_Mutation_p.V422L|SLC29A1_uc003oww.1_Missense_Mutation_p.V501L|SLC29A1_uc003owx.1_Missense_Mutation_p.V422L|SLC29A1_uc003owy.1_Missense_Mutation_p.V422L|SLC29A1_uc003owz.1_Missense_Mutation_p.V422L	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	422	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	GCTTAGGAAAGTGAAGCCAGC	0.597													0	0	0	0.010771	0	38	125										C	44201158	G	C	44201158	3	2	55	1	0	0	0	0	1	0	0	0	14534	1029	36	4	1310	4	SLC29A1	6	44201158	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1215265	44201158	126913909	143	16037										
DST	667	broad.mit.edu	37	chr6	56458781	56458781	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtcagcatcaaacttttctaAttcttcctgcagagagtgag	8	9	4	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:56458781A>T	uc003pdf.2	-	42	6077	c.6049T>A	c.(6049-6051)TTA>ATA	p.L2017I	DST_uc003pcz.3_Missense_Mutation_p.L1839I|DST_uc011dxj.1_Missense_Mutation_p.L1868I|DST_uc011dxk.1_Missense_Mutation_p.L1879I|DST_uc003pcy.3_Missense_Mutation_p.L1513I|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3925	Spectrin 2.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AACTTTTCTAATTCTTCCTGC	0.423													0	0	0	0.00874	0	42	45										T	56458781	A	T	56458781	3	4	55	1	0	0	0	0	1	0	0	0	4783	98	4	5	11202	5	DST	6	56458781	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	12257623	56458781	114656286	144	16038										
TFB1M	51106	broad.mit.edu	37	chr6	155619653	155619653	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	actttctgaaaaagccttttCtaccttaaatgtcaagacat	4	9	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:155619653C>G	uc003qqj.3	-	3	416	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	TFB1M_uc003qqk.2_Intron	NM_016020	NP_057104	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			skin(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		AAAGCCTTTTCTACCTTAAAT	0.338													0	0	0	0.01892	0	20	19										G	155619653	C	G	155619653	3	3	55	1	0	0	0	0	1	0	0	0	15790	922	32	1	708	1	TFB1M	6	155619653	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	99160872	155619653	15495414	145	16039										
SLC22A1	6580	broad.mit.edu	37	chr6	160560699	160560713	+	In_Frame_Del	DEL	TGCTCTATCAGGGGC	TGCTCTATCAGGGGC	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gctcaggttcacggactctgTgctctatcaggggctcatcc							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr6:160560699_160560713delTGCTCTATCAGGGGC	uc003qtc.2	+	7	1181_1195	c.1076_1090delTGCTCTATCAGGGGC	c.(1075-1092)GTGCTCTATCAGGGGCTC>GTC	p.LYQGL360del	SLC22A1_uc003qtd.2_In_Frame_Del_p.LYQGL360del	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	360_364	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		ACGGACTCTGTGCTCTATCAGGGGCTCATCCTGCA	0.516																		11	30	---	---								-	160560713	TGCTCTATCAGGGGC	-	160560699	7	5	55	1	0	1	0	1	0	0	0	0	14440	1696	59	0	1102	0	SLC22A1	6	160560699	In_Frame_Del	DEL	TGCTCTATCAGGGGC	TCGA-DK-A2I6-01A-12D-A18F-08	4941046	160560699	10554368	146	16040										
MEOX2	4223	broad.mit.edu	37	chr7	15725691	15725691	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctctgggggccctccagagtCgggctggaggcagaggctgt	18	11	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:15725691C>T	uc003stc.2	-	1	618	c.337G>A	c.(337-339)GAC>AAC	p.D113N	MEOX2_uc011jxw.1_Missense_Mutation_p.D113N	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	113					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		CCTCCAGAGTCGGGCTGGAGG	0.627													0	0	0	0.001984	0	7	6										T	15725691	C	T	15725691	3	4	55	1	0	0	0	0	1	0	0	0	9474	884	31	1	589	1	MEOX2	7	15725691	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		15725691	143412972	147	16041										
AOAH	313	broad.mit.edu	37	chr7	36671706	36671706	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aatgtcagaaccacttctagAatatttctggggagaaaaaa	8	6	3	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:36671706A>C	uc003tfh.3	-	6	858	c.457T>G	c.(457-459)TCT>GCT	p.S153A	AOAH_uc010kxf.2_Missense_Mutation_p.S153A|AOAH_uc011kba.1_Missense_Mutation_p.S121A	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	153					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						CCACTTCTAGAATATTTCTGG	0.393													0	0	0	0.001984	0	6	12										C	36671706	A	C	36671706	3	2	55	1	0	0	0	0	1	0	0	0	726	246	9	5	1675	5	AOAH	7	36671706	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	20946015	36671706	122466957	148	16042										
GLI3	2737	broad.mit.edu	37	chr7	42005045	42005045	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gggtctgatagcccccagcaGgcccgctcctcaaggggttc	13	15	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:42005045G>A	uc011kbh.1	-	15	3717	c.3626C>T	c.(3625-3627)CCT>CTT	p.P1209L	GLI3_uc011kbg.1_Missense_Mutation_p.P1150L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1209					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GCCCCCAGCAGGCCCGCTCCT	0.652									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.009096	0	4	104										A	42005045	G	A	42005045	3	1	55	1	0	0	0	0	1	0	0	0	6439	1000	35	2	1120	2	GLI3	7	42005045	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	5333339	42005045	117133618	149	16043										
ABCA13	154664	broad.mit.edu	37	chr7	48308595	48308595	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agcttttcctgaggaatctcCttgttttgaagaaaacatgg	9	7	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:48308595C>T	uc003toq.2	+	16	2049	c.2024C>T	c.(2023-2025)CCT>CTT	p.P675L	ABCA13_uc010kyr.2_Missense_Mutation_p.P178L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	675					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAGGAATCTCCTTGTTTTGAA	0.289													0	0	0	0.014758	0	5	27										T	48308595	C	T	48308595	3	4	55	1	0	0	0	0	1	0	0	0	31	681	24	2	1915	2	ABCA13	7	48308595	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	6303550	48308595	110830068	150	16044										
AUTS2	26053	broad.mit.edu	37	chr7	69364285	69364285	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctacagaaagatgtagcacTtaagcctcaggaacgtgtgg	11	8	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:69364285T>G	uc003tvw.3	+	2	1066	c.323T>G	c.(322-324)CTT>CGT	p.L108R	AUTS2_uc003tvv.3_Missense_Mutation_p.L108R|AUTS2_uc003tvx.3_Missense_Mutation_p.L108R	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	108										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GATGTAGCACTTAAGCCTCAG	0.443													0	0	0	0.010729	0	11	41										G	69364285	T	G	69364285	3	3	55	1	0	0	0	0	1	0	0	0	1225	1609	56	5	329	5	AUTS2	7	69364285	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	21055690	69364285	89774378	151	16045										
DNAJC30	84277	broad.mit.edu	37	chr7	73097379	73097379	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcgggcgtcctggagggccgGacgccaggtccgcgcaggtc	19	14	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:73097379G>A	uc003tys.1	-	1	403	c.375C>T	c.(373-375)GTC>GTT	p.V125V	WBSCR22_uc010lbi.1_5'Flank|WBSCR22_uc003tyt.2_5'Flank|WBSCR22_uc003tyu.2_5'Flank|WBSCR22_uc003tyv.2_5'Flank|WBSCR22_uc003tyw.1_5'Flank	NM_032317	NP_115693	Q96LL9	DJC30_HUMAN	DnaJ (Hsp40) homolog subfamily C member 30	125					protein folding		heat shock protein binding|unfolded protein binding				0						TGGAGGGCCGGACGCCAGGTC	0.741													0	0	0	0.004482	0	9	14										A	73097379	G	A	73097379	2	1	55	1	0	0	0	0	0	0	0	1	4648	1161	41	1		1	DNAJC30	7	73097379	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3733094	73097379	86041284	152	16046										
HIP1	3092	broad.mit.edu	37	chr7	75178216	75178216	+	Silent	SNP	A	A	T													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctggccgtggcagtttcaatAgcagctgaagtggccgccat							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:75178216A>T	uc003uds.1	-	23	2420	c.2379T>A	c.(2377-2379)GCT>GCA	p.A793A	HIP1_uc011kfz.1_Silent_p.A670A	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	793	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CAGTTTCAATAGCAGCTGAAG	0.552			T	PDGFRB	CMML								0	0	0	0.01441	0	59	139										T	75178216	A	T	75178216	2	4	55	1	0	0	0	0	0	0	0	1	7114	407	15	5		5	HIP1	7	75178216	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	2080837	75178216	83960447	153	16047	80	2								
HIP1	3092	broad.mit.edu	37	chr7	75178225	75178225	+	Silent	SNP	A	A	C													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcagtttcaatagcagctgaAgtggccgccatctccttgtc							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:75178225A>C	uc003uds.1	-	23	2411	c.2370T>G	c.(2368-2370)ACT>ACG	p.T790T	HIP1_uc011kfz.1_Silent_p.T667T	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	790	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TAGCAGCTGAAGTGGCCGCCA	0.567			T	PDGFRB	CMML								0	0	0	0.01441	0	62	134										C	75178225	A	C	75178225	2	2	55	1	0	0	0	0	0	0	0	1	7114	59	3	5		5	HIP1	7	75178225	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	9	75178225	83960438	154	16048	80	2								
SEMA3D	223117	broad.mit.edu	37	chr7	84751131	84751131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gaagaaacaacatggtcatgCttagcatcatcaaagcagga	9	8	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:84751131C>T	uc003uic.2	-	1	117	c.77G>A	c.(76-78)AGC>AAC	p.S26N	SEMA3D_uc010led.2_Missense_Mutation_p.S26N|SEMA3D_uc010lee.1_Missense_Mutation_p.S26N	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	26					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CATGGTCATGCTTAGCATCAT	0.333													0	0	0	0.006122	0	12	24										T	84751131	C	T	84751131	3	4	55	1	0	0	0	0	1	0	0	0	14027	797	28	2	2324	2	SEMA3D	7	84751131	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	9572906	84751131	74387532	155	16049										
KIAA1324L	222223	broad.mit.edu	37	chr7	86554951	86554951	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agccaagtgcaggctccgttCctgctggacatggtctacat	11	12	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:86554951C>A	uc011kha.1	-	10	1477	c.1292G>T	c.(1291-1293)GGA>GTA	p.G431V	KIAA1324L_uc003uif.1_Missense_Mutation_p.G191V|KIAA1324L_uc011kgz.1_Missense_Mutation_p.G317V|KIAA1324L_uc003uie.2_Missense_Mutation_p.G264V	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	431	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					AGGCTCCGTTCCTGCTGGACA	0.418													1	0	2.32078e-09	0.003163	2.61832e-09	16	48										A	86554951	C	A	86554951	3	1	55	1	0	0	0	0	1	0	0	0	8224	855	30	3	1849	3	KIAA1324L	7	86554951	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1803820	86554951	72583712	156	16050										
PTCD1	26024	broad.mit.edu	37	chr7	99032712	99032712	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcctggccgaggggcagctGagaggaggagctgctgaagg	19	9	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:99032712G>A	uc003uqh.2	-	2	285	c.154C>T	c.(154-156)CAG>TAG	p.Q52*	PTCD1_uc011kiw.1_Nonsense_Mutation_p.Q101*	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	52										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AGGGGCAGCTGAGAGGAGGAG	0.657													0	0	0	0.007413	0	20	18										A	99032712	G	A	99032712	4	1	55	1	0	0	0	0	0	1	0	0	12727	1299	45	1	1976	1	PTCD1	7	99032712	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	12477761	99032712	60105951	157	16051										
RELN	5649	broad.mit.edu	37	chr7	103214579	103214579	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agggaccgtccgggcttcccTtttcccagggccattgaagt	12	13	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:103214579T>C	uc003vca.2	-	30	4631	c.4471A>G	c.(4471-4473)AGG>GGG	p.R1491G	RELN_uc010liz.2_Missense_Mutation_p.R1491G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1491					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGGGCTTCCCTTTTCCCAGGG	0.468													0	0	0	0.009096	0	3	119										C	103214579	T	C	103214579	3	2	55	1	0	0	0	0	1	0	0	0	13220	1608	56	5	6055	5	RELN	7	103214579	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	4181867	103214579	55924084	158	16052										
CBLL1	79872	broad.mit.edu	37	chr7	107398668	107398668	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cattgttcaagggtgcaagaGaacatatttgtctcagagag	11	6	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:107398668G>A	uc003veq.2	+	6	851	c.521G>A	c.(520-522)AGA>AAA	p.R174K	CBLL1_uc011kme.1_Missense_Mutation_p.R53K|CBLL1_uc011kmf.1_Missense_Mutation_p.R173K	NM_024814	NP_079090	Q75N03	HAKAI_HUMAN	Cas-Br-M (murine) ecotropic retroviral	174	C2H2-type.				cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|skin(2)|lung(1)	5						GGGTGCAAGAGAACATATTTG	0.433													0	0	0	0.004007	0	15	52										A	107398668	G	A	107398668	3	1	55	1	0	0	0	0	1	0	0	0	2703	942	33	1	543	1	CBLL1	7	107398668	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4184089	107398668	51739995	159	16053										
GRM8	2918	broad.mit.edu	37	chr7	126086316	126086316	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcttgcgtttttgaacattCtgttctggatgaaaaattat	7	6	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:126086316C>T	uc003vlr.2	-	9	2852	c.2541G>A	c.(2539-2541)CAG>CAA	p.Q847Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.Q847Q|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	847	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTTGAACATTCTGTTCTGGAT	0.423										HNSCC(24;0.065)			0	0	0	0.010504	0	20	37										T	126086316	C	T	126086316	2	4	55	1	0	0	0	0	0	0	0	1	6803	912	32	1		1	GRM8	7	126086316	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	18687648	126086316	33052347	160	16054										
FLNC	2318	broad.mit.edu	37	chr7	128486934	128486934	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggagactatgacgtcaacatCaccttcggggggcggcccat	13	12	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:128486934C>G	uc003vnz.3	+	24	4472	c.4263C>G	c.(4261-4263)ATC>ATG	p.I1421M	FLNC_uc003voa.3_Missense_Mutation_p.I1421M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1421	Filamin 12.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						ACGTCAACATCACCTTCGGGG	0.602													0	0	0	0.010504	0	19	34										G	128486934	C	G	128486934	3	3	55	1	0	0	0	0	1	0	0	0	5935	816	29	1	4357	1	FLNC	7	128486934	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2400618	128486934	30651729	161	16055										
CALD1	800	broad.mit.edu	37	chr7	134643018	134643018	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccaagattgacagcagactgGagcagtataccagtgcaatt	10	9	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:134643018G>A	uc003vrz.2	+	11	2497	c.2038G>A	c.(2038-2040)GAG>AAG	p.E680K	CALD1_uc003vry.2_Missense_Mutation_p.E425K|CALD1_uc003vsa.2_Missense_Mutation_p.E451K|CALD1_uc003vsb.2_Missense_Mutation_p.E425K|CALD1_uc010lmm.2_Missense_Mutation_p.E450K|CALD1_uc011kpt.1_Missense_Mutation_p.E199K|CALD1_uc003vsc.2_Missense_Mutation_p.E445K|CALD1_uc003vsd.2_Missense_Mutation_p.E419K|CALD1_uc011kpu.1_Missense_Mutation_p.E430K|CALD1_uc011kpv.1_Missense_Mutation_p.E289K|CALD1_uc003vse.2_Missense_Mutation_p.E543K|CALD1_uc010lmn.2_5'Flank	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	680	Strong actin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						CAGCAGACTGGAGCAGTATAC	0.388													0	0	0	0.01441	0	59	49										A	134643018	G	A	134643018	3	1	55	1	0	0	0	0	1	0	0	0	2581	1175	41	1	2129	1	CALD1	7	134643018	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6156084	134643018	24495645	162	16056										
UBN2	254048	broad.mit.edu	37	chr7	138936757	138936757	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acaagatttaattgatatagGctttggctatgatgagacag	10	4	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:138936757G>C	uc011kqr.1	+	3	617	c.617G>C	c.(616-618)GGC>GCC	p.G206A		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	206										ovary(1)|skin(1)	2						ATTGATATAGGCTTTGGCTAT	0.383													0	0	0	0.016522	0	21	56										C	138936757	G	C	138936757	3	2	55	1	0	0	0	0	1	0	0	0	16890	1203	42	4	627	4	UBN2	7	138936757	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4293739	138936757	20201906	163	16057										
DNAJB6	10049	broad.mit.edu	37	chr7	157160089	157160089	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaagtcattttgacagtccAtttgaatttggcttcacatt	8	7	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr7:157160089A>G	uc003wnk.2	+	5	412	c.258A>G	c.(256-258)CCA>CCG	p.P86P	DNAJB6_uc003wnj.2_Silent_p.P86P|DNAJB6_uc003wnl.2_Silent_p.P73P|DNAJB6_uc011kvy.1_Silent_p.P37P|DNAJB6_uc011kvz.1_Silent_p.P86P|DNAJB6_uc010lqt.2_Silent_p.P86P	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	86	Gly/Phe-rich.|Interaction with HSP70.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		TTGACAGTCCATTTGAATTTG	0.363													0	0	0	0.009718	0	39	55										G	157160089	A	G	157160089	2	3	55	1	0	0	0	0	0	0	0	1	4624	204	8	5		5	DNAJB6	7	157160089	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	18223332	157160089	1978574	164	16058										
MYST3	7994	broad.mit.edu	37	chr8	41791525	41791525	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcttttaattcgattaactCttccttagtgtgggagtctt	7	8	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:41791525C>T	uc010lxb.2	-	18	4757	c.4213G>A	c.(4213-4215)GAG>AAG	p.E1405K	MYST3_uc010lxc.2_Missense_Mutation_p.E1405K|MYST3_uc003xon.3_Missense_Mutation_p.E1405K	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1405					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TCGATTAACTCTTCCTTAGTG	0.498													0	0	0	0.016522	0	25	141										T	41791525	C	T	41791525	3	4	55	1	0	0	0	0	1	0	0	0	10104	922	32	1	1805	1	MYST3	8	41791525	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		41791525	104572497	165	16059										
TRIM55	84675	broad.mit.edu	37	chr8	67086715	67086715	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttccattgcagattggatttGaggctcctcccctccaggga	10	12	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:67086715G>C	uc003xvv.2	+	10	1760	c.1534G>C	c.(1534-1536)GAG>CAG	p.E512Q	TRIM55_uc003xvu.2_Nonstop_Mutation_p.*541S|TRIM55_uc003xvw.2_Missense_Mutation_p.E416Q|TRIM55_uc003xvx.2_Missense_Mutation_p.E205Q	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	512						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GATTGGATTTGAGGCTCCTCC	0.468													0	0	0	0.003163	0	16	65										C	67086715	G	C	67086715	3	2	55	1	0	0	0	0	1	0	0	0	16526	1294	45	1	1664	1	TRIM55	8	67086715	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	25295190	67086715	79277307	166	16060										
TRPA1	8989	broad.mit.edu	37	chr8	72959440	72959440	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aacatgcagaaatctaaaagTacctttgaaagagaaaaacc	6	7	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:72959440T>C	uc003xza.2	-	16	2083	c.1908A>G	c.(1906-1908)GTA>GTG	p.V636V	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	636	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AATCTAAAAGTACCTTTGAAA	0.308													0	0	0	0.016723	0	11	48										C	72959440	T	C	72959440	2	2	55	1	0	0	0	0	0	0	0	1	16574	1625	57	5		5	TRPA1	8	72959440	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	5872725	72959440	73404582	167	16061										
VPS13B	157680	broad.mit.edu	37	chr8	100396448	100396448	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcttttaggtgctgtacttcTttgcagtatacaaggactag	9	7	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:100396448T>C	uc003yiv.2	+	20	2948	c.2837T>C	c.(2836-2838)CTT>CCT	p.L946P	VPS13B_uc003yiw.2_Missense_Mutation_p.L946P|VPS13B_uc003yiu.1_Missense_Mutation_p.L946P|VPS13B_uc003yix.1_Missense_Mutation_p.L417P	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	946					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCTGTACTTCTTTGCAGTATA	0.279													0	0	0	0.006214	0	9	257										C	100396448	T	C	100396448	3	2	55	1	0	0	0	0	1	0	0	0	17187	1609	56	5	3034	5	VPS13B	8	100396448	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	27437008	100396448	45967574	168	16062										
VPS13B	157680	broad.mit.edu	37	chr8	100523432	100523432	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgtccgccacaagttaacatCaagaaatgagcgaagaagtt	9	8	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:100523432C>T	uc003yiv.2	+	29	4511	c.4400C>T	c.(4399-4401)TCA>TTA	p.S1467L	VPS13B_uc003yiw.2_Missense_Mutation_p.S1442L|VPS13B_uc003yix.1_Missense_Mutation_p.S937L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1467					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGTTAACATCAAGAAATGAG	0.378													0	0	0	0.01441	0	142	22										T	100523432	C	T	100523432	3	4	55	1	0	0	0	0	1	0	0	0	17187	838	29	1	4704	1	VPS13B	8	100523432	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	126984	100523432	45840590	169	16063										
DPYS	1807	broad.mit.edu	37	chr8	105405182	105405182	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	catgccctcgaaaatgttgaAgttaacagcctgatgatgag	10	8	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:105405182A>C	uc003yly.3	-	8	1402	c.1273T>G	c.(1273-1275)TTC>GTC	p.F425V	DPYS_uc010mcf.1_5'UTR	NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	425					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAAATGTTGAAGTTAACAGCC	0.423													0	0	0	0.006214	0	9	56										C	105405182	A	C	105405182	3	2	55	1	0	0	0	0	1	0	0	0	4746	72	3	5	294	5	DPYS	8	105405182	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	4881750	105405182	40958840	170	16064										
ZFPM2	23414	broad.mit.edu	37	chr8	106814151	106814151	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	caacccagctgctcattctgCtgatcctgagaatccacttc	6	15	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr8:106814151C>A	uc003ymd.2	+	8	1864	c.1841C>A	c.(1840-1842)GCT>GAT	p.A614D	ZFPM2_uc011lhs.1_Missense_Mutation_p.A345D	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	614					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCTCATTCTGCTGATCCTGAG	0.463													1	0	3.86212e-05	0.008291	4.24833e-05	11	62										A	106814151	C	A	106814151	3	1	55	1	0	0	0	0	1	0	0	0	17655	797	28	4	1871	4	ZFPM2	8	106814151	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1408969	106814151	39549871	171	16065										
APTX	54840	broad.mit.edu	37	chr9	32974519	32974519	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttttttgtttttaaggcaagGagaatcaaaatcctggctga	9	5	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:32974519G>A	uc003zrm.2	-	6	1008	c.811C>T	c.(811-813)CCT>TCT	p.P271S	APTX_uc010mjm.2_RNA|APTX_uc003zrj.2_Missense_Mutation_p.P183S|APTX_uc011lns.1_Missense_Mutation_p.P92S|APTX_uc003zrl.2_Missense_Mutation_p.P97S|APTX_uc003zrn.2_Missense_Mutation_p.P183S|APTX_uc003zro.2_Missense_Mutation_p.P271S|APTX_uc003zrp.2_Missense_Mutation_p.P183S|APTX_uc003zrq.2_Missense_Mutation_p.P183S|APTX_uc003zrr.2_Missense_Mutation_p.P217S|APTX_uc003zrs.2_Missense_Mutation_p.P271S|APTX_uc003zrt.2_Missense_Mutation_p.P183S|APTX_uc003zru.2_Missense_Mutation_p.P217S|APTX_uc003zrv.2_Missense_Mutation_p.P285S|APTX_uc003zrw.2_Missense_Mutation_p.P199S|APTX_uc003zrx.2_Missense_Mutation_p.P271S|APTX_uc003zry.2_Missense_Mutation_p.P271S|APTX_uc003zrz.2_Missense_Mutation_p.P92S	NM_175072	NP_778242	Q7Z2E3	APTX_HUMAN	aprataxin isoform c	285	HIT.				cell death|double-strand break repair|regulation of protein stability|response to hydrogen peroxide|single strand break repair	chromatin|nucleolus|nucleoplasm	chromatin binding|damaged DNA binding|DNA 5'-adenosine monophosphate hydrolase activity|double-stranded DNA binding|double-stranded RNA binding|phosphoglycolate phosphatase activity|phosphoprotein binding|polynucleotide 3'-phosphatase activity|protein N-terminus binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0302)	GBM - Glioblastoma multiforme(74;0.105)		TTAAGGCAAGGAGAATCAAAA	0.318								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.005443	0	25	34										A	32974519	G	A	32974519	3	1	55	1	0	0	0	0	1	0	0	0	820	1174	41	1	234	1	APTX	9	32974519	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		32974519	108238912	172	16066										
NFX1	4799	broad.mit.edu	37	chr9	33366702	33366702	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggatcatccatgacttggccCaagtttatggcctggagagc	12	10	1	2	rs35178105		TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:33366702C>A	uc003zsq.2	+	22	3176	c.3115C>A	c.(3115-3117)CAA>AAA	p.Q1039K	SUGT1P1_uc010mjq.1_Intron|NFX1_uc003zsr.2_Missense_Mutation_p.Q1040K	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	1039	R3H.				inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TGACTTGGCCCAAGTTTATGG	0.517													1	0	2.6416e-12	0.00623	2.99563e-12	40	63										A	33366702	C	A	33366702	3	1	55	1	0	0	0	0	1	0	0	0	10387	595	21	4	3319	4	NFX1	9	33366702	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	392183	33366702	107846729	173	16067										
FRMD3	257019	broad.mit.edu	37	chr9	86153040	86153040	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccgagtcgtccagcagccggAtggtgcatctcatctcctgg	12	14	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:86153040A>G	uc004ams.1	-	1	309	c.107T>C	c.(106-108)ATC>ACC	p.I36T	FRMD3_uc004amr.1_Missense_Mutation_p.I22T	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	36	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						CAGCAGCCGGATGGTGCATCT	0.652													0	0	0	0.004482	0	9	16										G	86153040	A	G	86153040	3	3	55	1	0	0	0	0	1	0	0	0	6050	333	12	5	1742	5	FRMD3	9	86153040	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	52786338	86153040	55060391	174	16068										
NTRK2	4915	broad.mit.edu	37	chr9	87338604	87338604	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atatgtattgggatgttggtAacctggtttccaaacatatg	10	5	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:87338604A>T	uc004aoa.1	+	9	1638	c.700A>T	c.(700-702)AAC>TAC	p.N234Y	NTRK2_uc004anv.1_Missense_Mutation_p.N234Y|NTRK2_uc004any.1_Missense_Mutation_p.N234Y|NTRK2_uc004anz.1_Missense_Mutation_p.N234Y|NTRK2_uc011lsz.1_Missense_Mutation_p.N234Y|NTRK2_uc011lta.1_Missense_Mutation_p.N234Y|NTRK2_uc004aob.1_Missense_Mutation_p.N234Y|NTRK2_uc011ltb.1_Missense_Mutation_p.N78Y	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	234	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						GGATGTTGGTAACCTGGTTTC	0.433										TSP Lung(25;0.17)			0	0	0	0.007413	0	17	88										T	87338604	A	T	87338604	3	4	55	1	0	0	0	0	1	0	0	0	10707	362	13	5	722	5	NTRK2	9	87338604	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	1185564	87338604	53874827	175	16069										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123151529	123151529	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcttctcaggagcctggtctGctgggactgcatgttcctgg	13	11	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:123151529G>A	uc004bkf.2	-	38	5848	c.5667C>T	c.(5665-5667)AGC>AGT	p.S1889S	CDK5RAP2_uc010mvi.2_Silent_p.S898S|CDK5RAP2_uc004bke.2_Silent_p.S1174S|CDK5RAP2_uc004bkg.2_Silent_p.S1810S|CDK5RAP2_uc011lxw.1_Silent_p.S1154S|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Silent_p.S1154S|CDK5RAP2_uc011lya.1_Silent_p.S1154S	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1889	Interaction with PCNT and AKAP9.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						AGCCTGGTCTGCTGGGACTGC	0.473													0	0	0	0.004482	0	9	9										A	123151529	G	A	123151529	2	1	55	1	0	0	0	0	0	0	0	1	3146	1310	46	2		2	CDK5RAP2	9	123151529	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	35812925	123151529	18061902	176	16070										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123169489	123169489	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aggaggctgtgcaggtccctGaaaggatcctgccccttcca	12	13	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:123169489G>A	uc004bkf.2	-	32	4945	c.4764C>T	c.(4762-4764)TTC>TTT	p.F1588F	CDK5RAP2_uc010mvi.2_Silent_p.F597F|CDK5RAP2_uc004bke.2_Silent_p.F873F|CDK5RAP2_uc004bkg.2_Intron|CDK5RAP2_uc011lxw.1_Silent_p.F853F|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Silent_p.F853F|CDK5RAP2_uc011lya.1_Silent_p.F853F|CDK5RAP2_uc004bkh.1_Silent_p.F1358F|CDK5RAP2_uc004bki.2_3'UTR	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1588					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						GCAGGTCCCTGAAAGGATCCT	0.567													0	0	0	0.010504	0	19	40										A	123169489	G	A	123169489	2	1	55	1	0	0	0	0	0	0	0	1	3146	1281	45	1		1	CDK5RAP2	9	123169489	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	17960	123169489	18043942	177	16071										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123170639	123170639	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagtacctctcagtctcctgTgctcttcatccagcttctca	5	16	5	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:123170639T>A	uc004bkf.2	-	31	4893	c.4712A>T	c.(4711-4713)CAC>CTC	p.H1571L	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.H580L|CDK5RAP2_uc004bke.2_Missense_Mutation_p.H856L|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.H1571L|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.H836L|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.H836L|CDK5RAP2_uc011lya.1_Missense_Mutation_p.H836L|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.H1341L|CDK5RAP2_uc004bki.2_Missense_Mutation_p.H1338L	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1571					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CAGTCTCCTGTGCTCTTCATC	0.557													0	0	0	0.021022	0	36	35										A	123170639	T	A	123170639	3	1	55	1	0	0	0	0	1	0	0	0	3146	1696	59	5	1001	5	CDK5RAP2	9	123170639	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	1150	123170639	18042792	178	16072										
RBM18	92400	broad.mit.edu	37	chr9	125009805	125009805	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctcagacgtacctttacttGagcatgtgcccatcgcacca	7	14	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:125009805G>A	uc004bma.2	-	4	485	c.319C>T	c.(319-321)CAA>TAA	p.Q107*	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_Intron	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	107							nucleotide binding|RNA binding				0						ACCTTTACTTGAGCATGTGCC	0.498													0	0	0	0.013537	0	13	30										A	125009805	G	A	125009805	4	1	55	1	0	0	0	0	0	1	0	0	13120	1299	45	1	265	1	RBM18	9	125009805	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1839166	125009805	16203626	179	16073										
GARNL3	84253	broad.mit.edu	37	chr9	130147318	130147318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccttgcagtctgtgctttccCgtatctcctggccttcacca	7	16	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:130147318C>T	uc011mae.1	+	24	2683	c.2282C>T	c.(2281-2283)CCG>CTG	p.P761L	GARNL3_uc011mad.1_Missense_Mutation_p.P739L|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	761	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTGCTTTCCCGTATCTCCTG	0.617													0	0	0	0.021523	0	24	65										T	130147318	C	T	130147318	3	4	55	1	0	0	0	0	1	0	0	0	6241	652	23	2	2376	2	GARNL3	9	130147318	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5137513	130147318	11066113	180	16074										
FAM73B	84895	broad.mit.edu	37	chr9	131802905	131802905	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagggccgagggcacgtctaTgatccaggccctggccatga	15	12	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:131802905T>C	uc004bxa.2	+	2	218	c.32T>C	c.(31-33)ATG>ACG	p.M11T	FAM73B_uc004bwy.2_RNA|FAM73B_uc004bwz.2_RNA|FAM73B_uc011mbn.1_Missense_Mutation_p.M11T	NM_032809	NP_116198	Q7L4E1	FA73B_HUMAN	hypothetical protein LOC84895	11	Helical; (Potential).					integral to membrane				skin(1)	1						GGCACGTCTATGATCCAGGCC	0.597													0	0	0	0.00874	0	40	47										C	131802905	T	C	131802905	3	2	55	1	0	0	0	0	1	0	0	0	5618	1464	51	5	34	5	FAM73B	9	131802905	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	1655587	131802905	9410526	181	16075										
MED27	9442	broad.mit.edu	37	chr9	134955168	134955169	+	Nonsense_Mutation	DNP	GG	GG	AA													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cacgctggagcgcagcgcctGgatggcactaatggcctggg							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr9:134955168_134955169GG>AA	uc004cbe.1	-	1	85_86	c.63_64CC>TT	c.(61-66)ATCCAG>ATTTAG	p.Q22*	MED27_uc004cbf.1_Nonsense_Mutation_p.Q22*|MED27_uc011mco.1_Nonsense_Mutation_p.Q22*|MED27_uc004cbg.3_Nonsense_Mutation_p.Q22*	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	22					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		CGCAGCGCCTGGATGGCACTAA	0.609													0	0	0	0.004672	0	17	12										AA	134955169	GG	AA	134955168	4	1	55	1	0	0	0	0	0	1	0	0	9445	1357	47	2	903	2	MED27	9	134955168	Nonsense_Mutation	DNP	GG	TCGA-DK-A2I6-01A-12D-A18F-08	3152263	134955168	6258263	182	16076										
ARHGAP21	57584	broad.mit.edu	37	chr10	24880173	24880173	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cctgatacatctcctggggaGactcctgtccttccaatgtt	8	13	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:24880173G>A	uc001isb.2	-	24	4618	c.4131C>T	c.(4129-4131)GTC>GTT	p.V1377V	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1376					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						CTCCTGGGGAGACTCCTGTCC	0.438													0	0	0	0.01441	0	75	84										A	24880173	G	A	24880173	2	1	55	1	0	0	0	0	0	0	0	1	871	929	33	1		1	ARHGAP21	10	24880173	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		24880173	110654574	183	16077										
CSTF2T	23283	broad.mit.edu	37	chr10	53459010	53459012	+	In_Frame_Del	DEL	CTC	CTC	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcaggcccaaggctctttaaCtcctccttattcttttcact							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:53459010_53459012delCTC	uc001jjp.2	-	1	344_346	c.298_300delGAG	c.(298-300)GAGdel	p.E100del	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	100					mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GGCTCTTTAACTCCTCCTTATTC	0.557																		21	107	---	---								-	53459012	CTC	-	53459010	7	5	55	1	0	1	0	1	0	0	0	0	3985	564	20	0	1554	0	CSTF2T	10	53459010	In_Frame_Del	DEL	CTC	TCGA-DK-A2I6-01A-12D-A18F-08	28578837	53459010	82075737	184	16078										
LRRTM3	347731	broad.mit.edu	37	chr10	68688007	68688007	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctacgtgtcatggaagcggTaccctgcgagcatgaagcag	13	10	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:68688007T>C	uc001jmz.1	+	2	1883	c.1333T>C	c.(1333-1335)TAC>CAC	p.Y445H	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.Y445H	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	445	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						ATGGAAGCGGTACCCTGCGAG	0.552													0	0	0	0.007413	0	18	57										C	68688007	T	C	68688007	3	2	55	1	0	0	0	0	1	0	0	0	9041	1638	57	5	1339	5	LRRTM3	10	68688007	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	15228997	68688007	66846740	185	16079										
CDHR1	92211	broad.mit.edu	37	chr10	85973933	85973933	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gccggcaccatggccaccgtCgtggccatcactgtcctcat	10	17	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:85973933C>T	uc001kcv.2	+	17	2136	c.2136C>T	c.(2134-2136)GTC>GTT	p.V712V	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Silent_p.V416V|CDHR1_uc001kcx.2_Silent_p.V26V	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	712	Helical; (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						TGGCCACCGTCGTGGCCATCA	0.637													0	0	0	0.012319	0	22	55										T	85973933	C	T	85973933	2	4	55	1	0	0	0	0	0	0	0	1	3118	871	31	1		1	CDHR1	10	85973933	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	17285926	85973933	49560814	186	16080										
PTEN	5728	broad.mit.edu	37	chr10	89717673	89717673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctccaattcaggacccacacGacgggaagacaagttcatgt	9	12	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:89717673G>A	uc001kfb.2	+	8	1729	c.698G>A	c.(697-699)CGA>CAA	p.R233Q		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	233	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R233*(61)|p.R233fs*10(4)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.R233R(1)|p.G165_*404del(1)|p.?(1)|p.R233fs*12(1)|p.R233fs*20(1)|p.R233fs*25(1)|p.R233fs*23(1)|p.G165_K342del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGACCCACACGACGGGAAGAC	0.423		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			0	0	0	0.006122	0	17	44										A	89717673	G	A	89717673	3	1	55	1	0	0	0	0	1	0	0	0	12738	1058	37	1	724	1	PTEN	10	89717673	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3743740	89717673	45817074	187	16081										
CALHM2	51063	broad.mit.edu	37	chr10	105209283	105209283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttccctggccgtgagtgagGaagggtccacgaactcactg	13	12	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:105209283G>A	uc001kwz.2	-	2	802	c.416C>T	c.(415-417)TCC>TTC	p.S139F	CALHM2_uc001kxa.2_Missense_Mutation_p.S139F|CALHM2_uc001kxc.2_Missense_Mutation_p.S139F|CALHM2_uc001kxb.2_Missense_Mutation_p.S139F|CALHM2_uc001kxd.1_Missense_Mutation_p.S139F	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	139						integral to membrane				skin(1)	1						CGTGAGTGAGGAAGGGTCCAC	0.597													0	0	0	0.016522	0	23	49										A	105209283	G	A	105209283	3	1	55	1	0	0	0	0	1	0	0	0	2583	1174	41	1	563	1	CALHM2	10	105209283	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	15491610	105209283	30325464	188	16082										
TACC2	10579	broad.mit.edu	37	chr10	123845774	123845774	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggagcagaagacagtggagtGaaagctgtttcctctgcaga	14	7	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr10:123845774G>A	uc001lfv.2	+	4	4119	c.3759G>A	c.(3757-3759)GTG>GTA	p.V1253V	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.V1253V|TACC2_uc010qtv.1_Silent_p.V1253V	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1253						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACAGTGGAGTGAAAGCTGTTT	0.592													0	0	0	0.005524	0	36	54										A	123845774	G	A	123845774	2	1	55	1	0	0	0	0	0	0	0	1	15499	1277	45	1		1	TACC2	10	123845774	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	18636491	123845774	11688973	189	16083										
MUC6	4588	broad.mit.edu	37	chr11	1027765	1027765	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtacgtagtcgcccagggcgGcacagatgtggggaaaggtc	17	9	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:1027765G>A	uc001lsw.2	-	16	1952	c.1901C>T	c.(1900-1902)GCC>GTC	p.A634V		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	634					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCCAGGGCGGCACAGATGTG	0.662													0	0	0	0.008291	0	10	4										A	1027765	G	A	1027765	3	1	55	1	0	0	0	0	1	0	0	0	9980	1203	42	2	5490	2	MUC6	11	1027765	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		1027765	133978751	190	16084										
MUC6	4588	broad.mit.edu	37	chr11	1028662	1028662	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcacctctggtctgacctctGaactggggcccaacagtgac	10	14	4	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:1028662G>A	uc001lsw.2	-	13	1626	c.1575C>T	c.(1573-1575)TTC>TTT	p.F525F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	525	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGACCTCTGAACTGGGGCC	0.627													0	0	0	0.006214	0	9	3										A	1028662	G	A	1028662	2	1	55	1	0	0	0	0	0	0	0	1	9980	1281	45	1		1	MUC6	11	1028662	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	897	1028662	133977854	191	16085										
MUC2	4583	broad.mit.edu	37	chr11	1083168	1083168	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aggccgacagccactgtctcGagggctttgcgcctgtggac	14	13	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:1083168G>C	uc001lsx.1	+	16	2095	c.2068G>C	c.(2068-2070)GAG>CAG	p.E690Q		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	690						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCACTGTCTCGAGGGCTTTGC	0.662													0	0	0	0.006122	0	14	17										C	1083168	G	C	1083168	3	2	55	1	0	0	0	0	1	0	0	0	9975	1059	37	1	2130	1	MUC2	11	1083168	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	54506	1083168	133923348	192	16086										
PARVA	55742	broad.mit.edu	37	chr11	12525871	12525871	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttcatttcagctgttcatgcCaagagcctggtggccatctt	9	11	4	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:12525871C>T	uc001mki.2	+	6	601	c.552C>T	c.(550-552)GCC>GCT	p.A184A	PARVA_uc010rck.1_Silent_p.A131A	NM_018222	NP_060692	Q9NVD7	PARVA_HUMAN	parvin, alpha	184	CH 1.				cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)	3				Epithelial(150;0.00624)		CTGTTCATGCCAAGAGCCTGG	0.458													0	0	0	0.003163	0	15	7										T	12525871	C	T	12525871	2	4	55	1	0	0	0	0	0	0	0	1	11468	581	21	2		2	PARVA	11	12525871	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	11442703	12525871	122480645	193	16087										
AMBRA1	55626	broad.mit.edu	37	chr11	46419037	46419037	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcccctagggcctgcagcgTcccccctgctgctgccacca	9	21	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:46419037T>C	uc010rgu.1	-	18	4220	c.3860A>G	c.(3859-3861)GAC>GGC	p.D1287G	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.D1258G|AMBRA1_uc001ncu.1_Missense_Mutation_p.D1197G|AMBRA1_uc001ncv.2_Missense_Mutation_p.D1290G|AMBRA1_uc001ncw.2_Missense_Mutation_p.D1168G|AMBRA1_uc001ncx.2_Missense_Mutation_p.D1227G	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1287					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GCCTGCAGCGTCCCCCCTGCT	0.602													0	0	0	0.009096	0	3	79										C	46419037	T	C	46419037	3	2	55	1	0	0	0	0	1	0	0	0	565	1667	58	5	40	5	AMBRA1	11	46419037	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	33893166	46419037	88587479	194	16088										
LRP4	4038	broad.mit.edu	37	chr11	46920516	46920516	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccatcgcagtggtagatgtcGaggatgcagcgtccataggc	14	10	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:46920516G>A	uc001ndn.3	-	6	761	c.615C>T	c.(613-615)CTC>CTT	p.L205L	LRP4_uc009ylh.1_Silent_p.L156L	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	205	Extracellular (Potential).|LDL-receptor class A 5.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GGTAGATGTCGAGGATGCAGC	0.642													0	0	0	0.008871	0	20	10										A	46920516	G	A	46920516	2	1	55	1	0	0	0	0	0	0	0	1	8959	1045	37	1		1	LRP4	11	46920516	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	501479	46920516	88086000	195	16089										
PTPMT1	114971	broad.mit.edu	37	chr11	47587500	47587500	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcggggtgatcaccatgaacGaggagtacgagacgaggttc	16	8	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:47587500G>A	uc001nfs.3	+	2	410	c.217G>A	c.(217-219)GAG>AAG	p.E73K	PTPMT1_uc001nfv.3_Missense_Mutation_p.R109Q|PTPMT1_uc009ylt.2_Missense_Mutation_p.E73K|PTPMT1_uc001nfu.3_Missense_Mutation_p.R109Q|NDUFS3_uc001nft.3_5'UTR	NM_175732	NP_783859	Q8WUK0	PTPM1_HUMAN	protein tyrosine phosphatase, mitochondrial 1	73					inositol phosphate dephosphorylation	mitochondrial inner membrane	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(1)	1						CACCATGAACGAGGAGTACGA	0.677													0	0	0	0.010504	0	15	20										A	47587500	G	A	47587500	3	1	55	1	0	0	0	0	1	0	0	0	12778	1059	37	1	328	1	PTPMT1	11	47587500	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	666984	47587500	87419016	196	16090										
MAP4K2	5871	broad.mit.edu	37	chr11	64570095	64570095	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggcactcacgcaggatggtgAtttcctgctggagggagctg	16	9	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:64570095A>G	uc001obh.2	-	3	277	c.185T>C	c.(184-186)ATC>ACC	p.I62T	MAP4K2_uc001obi.2_Missense_Mutation_p.I62T|MAP4K2_uc010rnp.1_Missense_Mutation_p.I62T	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	62	Protein kinase.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CAGGATGGTGATTTCCTGCTG	0.552													0	0	0	0.003163	0	11	20										G	64570095	A	G	64570095	3	3	55	1	0	0	0	0	1	0	0	0	9260	333	12	5	2397	5	MAP4K2	11	64570095	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	16982595	64570095	70436421	197	16091										
MUS81	80198	broad.mit.edu	37	chr11	65628568	65628568	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gctgcagcggcaccgaacatCgggcggtgagcgcctcggaa	16	13	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:65628568C>T	uc001ofv.3	+	2	613	c.260C>T	c.(259-261)TCG>TTG	p.S87L	CFL1_uc001ofs.2_5'Flank|CFL1_uc001oft.2_5'Flank|CFL1_uc001ofu.2_5'Flank|MUS81_uc001ofw.3_RNA|MUS81_uc001ofx.3_5'Flank	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	87					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		CACCGAACATCGGGCGGTGAG	0.662								Homologous_recombination					0	0	0	0.005524	0	35	38										T	65628568	C	T	65628568	3	4	55	1	0	0	0	0	1	0	0	0	9988	893	31	1	266	1	MUS81	11	65628568	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1058473	65628568	69377948	198	16092										
SSH3	54961	broad.mit.edu	37	chr11	67071614	67071614	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggcggtccagcgaaggagtcGactccagcgaaggtgagcgc	17	11	0	1	rs138958962		TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:67071614G>A	uc001okj.2	+	2	270	c.92G>A	c.(91-93)CGA>CAA	p.R31Q	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_5'UTR	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	31					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CGAAGGAGTCGACTCCAGCGA	0.692													0	0	0	0.016723	0	13	14										A	67071614	G	A	67071614	3	1	55	1	0	0	0	0	1	0	0	0	15185	1058	37	1	98	1	SSH3	11	67071614	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1443046	67071614	67934902	199	16093										
PITPNM1	9600	broad.mit.edu	37	chr11	67271650	67271650	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgtggtattccttgatgagcAtcctgaaggcgctcggcggg	15	9	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:67271650A>G	uc001olx.2	-	1	191	c.2T>C	c.(1-3)ATG>ACG	p.M1T	PITPNM1_uc001oly.2_Missense_Mutation_p.M1T|PITPNM1_uc001olz.2_Missense_Mutation_p.M1T	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	1					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						CTTGATGAGCATCCTGAAGGC	0.706													0	0	0	0.006214	0	10	25										G	67271650	A	G	67271650	3	3	55	1	0	0	0	0	1	0	0	0	11950	217	8	5	3824	5	PITPNM1	11	67271650	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	200036	67271650	67734866	200	16094										
ARAP1	116985	broad.mit.edu	37	chr11	72420989	72420989	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acgttgcccacgctcatgtcGatgaaggtgatgccaatgcc	11	12	1	2	rs77842696	byFrequency	TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:72420989G>C	uc001osu.2	-	11	1638	c.1449C>G	c.(1447-1449)ATC>ATG	p.I483M	ARAP1_uc001osv.2_Missense_Mutation_p.I483M|ARAP1_uc001osr.2_Missense_Mutation_p.I243M|ARAP1_uc001oss.2_Missense_Mutation_p.I238M|ARAP1_uc009yth.2_Missense_Mutation_p.I238M|ARAP1_uc010rre.1_Missense_Mutation_p.I238M	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	483	PH 2.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CGCTCATGTCGATGAAGGTGA	0.622													0	0	0	0.012213	0	34	64										C	72420989	G	C	72420989	3	2	55	1	0	0	0	0	1	0	0	0	838	1048	37	1	3003	1	ARAP1	11	72420989	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	5149339	72420989	62585527	201	16095										
MLL	4297	broad.mit.edu	37	chr11	118342391	118342391	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acacagttaaaactagtcctCgaaaacctcgtgggagacct	8	11	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:118342391C>T	uc001pta.2	+	3	540	c.517C>T	c.(517-519)CGA>TGA	p.R173*	MLL_uc001ptb.2_Nonsense_Mutation_p.R173*|MLL_uc001psz.1_Nonsense_Mutation_p.R206*|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	173	A.T hook 1.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		AACTAGTCCTCGAAAACCTCG	0.383			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.004482	0	8	15										T	118342391	C	T	118342391	4	4	55	1	0	0	0	0	0	1	0	0	9620	876	31	1	527	1	MLL	11	118342391	Nonsense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	45921402	118342391	16664125	202	16096										
ZNF202	7753	broad.mit.edu	37	chr11	123598256	123598256	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gatatctgggacccaaggctCttcctctctaacctgggaga	10	12	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:123598256C>T	uc001pzd.1	-	8	1280	c.880G>A	c.(880-882)GAG>AAG	p.E294K	ZNF202_uc001pzc.1_Missense_Mutation_p.E70K|ZNF202_uc001pze.1_Missense_Mutation_p.E294K|ZNF202_uc001pzf.1_Missense_Mutation_p.E294K	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	294	KRAB.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		ACCCAAGGCTCTTCCTCTCTA	0.483													0	0	0	0.016522	0	22	25										T	123598256	C	T	123598256	3	4	55	1	0	0	0	0	1	0	0	0	17760	922	32	1	1074	1	ZNF202	11	123598256	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5255865	123598256	11408260	203	16097										
TP53AIP1	63970	broad.mit.edu	37	chr11	128805599	128805599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gaaaggcctggagagacctaGaccaaggcctcagtagggag	15	9	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:128805599G>C	uc001qey.2	-	4	472	c.262C>G	c.(262-264)CTA>GTA	p.L88V	TP53AIP1_uc001qex.2_3'UTR			Q9HCN2	TPIP1_HUMAN	RecName: Full=p53-regulated apoptosis-inducing protein 1;          Short=p53AIP1;	88					apoptosis	mitochondrion				lung(1)	1						GAGAGACCTAGACCAAGGCCT	0.463													0	0	0	0.004672	0	3	5										C	128805599	G	C	128805599	3	2	55	1	0	0	0	0	1	0	0	0	16379	957	33	1		1	TP53AIP1	11	128805599	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	5207343	128805599	6200917	204	16098										
SNX19	399979	broad.mit.edu	37	chr11	130785628	130785628	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgacctgaagccactccagcGaggctggagcccagccatcc	11	17	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr11:130785628G>A	uc001qgk.3	-	1	755	c.207C>T	c.(205-207)CTC>CTT	p.L69L	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.L69L|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	69					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCACTCCAGCGAGGCTGGAGC	0.602													0	0	0	0.004482	0	9	42										A	130785628	G	A	130785628	2	1	55	1	0	0	0	0	0	0	0	1	14890	1045	37	1		1	SNX19	11	130785628	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1980029	130785628	4220888	205	16099										
B4GALNT3	283358	broad.mit.edu	37	chr12	645436	645436	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagcagctacttgaagtggaAcaagcctgtcccctggctct	10	13	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:645436A>G	uc001qii.1	+	3	326	c.326A>G	c.(325-327)AAC>AGC	p.N109S		NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	109	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TTGAAGTGGAACAAGCCTGTC	0.448													0	0	0	0.003163	0	14	84										G	645436	A	G	645436	3	3	55	1	0	0	0	0	1	0	0	0	1268	43	2	5	336	5	B4GALNT3	12	645436	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08		645436	133206459	206	16100										
KCNA6	3742	broad.mit.edu	37	chr12	4920654	4920654	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agtatacccacgtcacttgtGggcagcctgcgccggacctg	12	14	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:4920654G>A	uc001qng.2	+	1	2313	c.1447G>A	c.(1447-1449)GGG>AGG	p.G483R		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	483						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CGTCACTTGTGGGCAGCCTGC	0.607										HNSCC(72;0.22)			0	0	0	0.012319	0	21	48										A	4920654	G	A	4920654	3	1	55	1	0	0	0	0	1	0	0	0	8007	1348	47	2	1449	2	KCNA6	12	4920654	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4275218	4920654	128931241	207	16101										
CD163	9332	broad.mit.edu	37	chr12	7635263	7635263	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aagccgctgtctctgtcttcGctttttagtcaagaagaata	8	9	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:7635263G>A	uc001qsz.3	-	14	3351	c.3223C>T	c.(3223-3225)CGA>TGA	p.R1075*	CD163_uc001qta.3_Nonsense_Mutation_p.R1075*|CD163_uc009zfw.2_Nonsense_Mutation_p.R1108*	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1075	Cytoplasmic (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CTCTGTCTTCGCTTTTTAGTC	0.433													0	0	0	0.01441	0	61	72										A	7635263	G	A	7635263	4	1	55	1	0	0	0	0	0	1	0	0	2967	1095	38	2	259	2	CD163	12	7635263	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2714609	7635263	126216632	208	16102										
SLC2A3	6515	broad.mit.edu	37	chr12	8083956	8083956	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcacaaaacctgtgcagagtCcgcagaagaggccaataacc	10	12	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:8083956C>A	uc001qtr.2	-	4	657	c.395G>T	c.(394-396)GGA>GTA	p.G132V	SLC2A3_uc001qts.2_Missense_Mutation_p.G132V	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	132	Helical; Name=4; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TGTGCAGAGTCCGCAGAAGAG	0.537													1	0	2.12542e-12	0.00632	2.41649e-12	27	70										A	8083956	C	A	8083956	3	1	55	1	0	0	0	0	1	0	0	0	14545	855	30	3	1123	3	SLC2A3	12	8083956	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	448693	8083956	125767939	209	16103										
SOX5	6660	broad.mit.edu	37	chr12	23999076	23999076	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttctgccttctgaggtgaggTagatgagttgtgtggggcaa	16	5	2	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:23999076T>A	uc001rfw.2	-	3	424	c.322A>T	c.(322-324)ACC>TCC	p.T108S	SOX5_uc001rfx.2_Missense_Mutation_p.T95S|SOX5_uc001rfy.2_Missense_Mutation_p.T95S|SOX5_uc010siv.1_Missense_Mutation_p.T95S|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.T60S|SOX5_uc001rga.2_Missense_Mutation_p.T73S	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	108					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TGAGGTGAGGTAGATGAGTTG	0.468													0	0	0	0.004656	0	22	59										A	23999076	T	A	23999076	3	1	55	1	0	0	0	0	1	0	0	0	14954	1638	57	5	2031	5	SOX5	12	23999076	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	15915120	23999076	109852819	210	16104										
C12orf77	196415	broad.mit.edu	37	chr12	25149238	25149238	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctggcttcctttatgactagGagggaaatgtctctgggtgt	13	7	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:25149238G>A	uc001rgf.2	-	2	244	c.39C>T	c.(37-39)CTC>CTT	p.L13L		NM_001101339	NP_001094809	C9JDV5	CL097_HUMAN	hypothetical protein LOC196415	13											0						TTATGACTAGGAGGGAAATGT	0.408													0	0	0	0.00499	0	14	57										A	25149238	G	A	25149238	2	1	55	1	0	0	0	0	0	0	0	1	1716	1161	41	1		1	C12orf77	12	25149238	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1150162	25149238	108702657	211	16105										
DDX11	1663	broad.mit.edu	37	chr12	31256902	31256902	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaggagagtgtggagtccaGagtgctgccaggacccaggc	18	9	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:31256902G>A	uc001rjt.1	+	27	3099	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	DDX11_uc001rjr.1_3'UTR|DDX11_uc001rjs.1_3'UTR|DDX11_uc001rju.1_3'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.E950K|DDX11_uc001rjw.1_3'UTR|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_Missense_Mutation_p.E119K	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	950					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GTGGAGTCCAGAGTGCTGCCA	0.592										Multiple Myeloma(12;0.14)			0	0	0	0.001168	0	6	6										A	31256902	G	A	31256902	3	1	55	1	0	0	0	0	1	0	0	0	4343	943	33	1	2955	1	DDX11	12	31256902	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6107664	31256902	102594993	212	16106										
SMAGP	57228	broad.mit.edu	37	chr12	51639758	51639758	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcctctttctcgctgcccttGgccaagtcactctccatctg	6	17	5	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:51639758G>T	uc001ryc.1	-	3	932	c.261C>A	c.(259-261)GCC>GCA	p.A87A	SMAGP_uc001ryd.1_Silent_p.A87A|SMAGP_uc001rye.1_Silent_p.A87A|SMAGP_uc001ryf.1_RNA|DAZAP2_uc010snf.1_Intron	NM_001033873	NP_001029045	Q0VAQ4	SMAGP_HUMAN	small trans-membrane and glycosylated protein	87	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|plasma membrane					0						CGCTGCCCTTGGCCAAGTCAC	0.488													1	0	3.8784e-16	0.012319	4.49078e-16	22	36										T	51639758	G	T	51639758	2	4	55	1	0	0	0	0	0	0	0	1	14765	1335	47	4		4	SMAGP	12	51639758	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	20382856	51639758	82212137	213	16107										
KRT2	3849	broad.mit.edu	37	chr12	53040646	53040646	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aagtcctccttggcctgctgCagggcctcctccaggtcatt	10	15	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:53040646C>G	uc001sat.2	-	7	1380	c.1347G>C	c.(1345-1347)CTG>CTC	p.L449L		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	449	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		TGGCCTGCTGCAGGGCCTCCT	0.587													0	0	0	0.008291	0	10	78										G	53040646	C	G	53040646	2	3	55	1	0	0	0	0	0	0	0	1	8457	697	25	4		4	KRT2	12	53040646	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1400888	53040646	80811249	214	16108										
CSAD	51380	broad.mit.edu	37	chr12	53565213	53565213	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gatttacagcatacatgttgGagatggagccacctgtcaca	10	9	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:53565213G>C	uc001sby.2	-	7	590	c.464C>G	c.(463-465)TCC>TGC	p.S155C	CSAD_uc001sbw.2_Intron|CSAD_uc009zmt.2_Intron|CSAD_uc010snx.1_Missense_Mutation_p.S182C|CSAD_uc001sbz.2_Missense_Mutation_p.S155C|CSAD_uc009zmu.2_Intron|CSAD_uc001sca.3_RNA|CSAD_uc010sny.1_3'UTR	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	155					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	ATACATGTTGGAGATGGAGCC	0.597									Hereditary_Prostate_Cancer				0	0	0	0.008291	0	11	29										C	53565213	G	C	53565213	3	2	55	1	0	0	0	0	1	0	0	0	3925	1174	41	1	1057	1	CSAD	12	53565213	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	524567	53565213	80286682	215	16109										
ITGA7	3679	broad.mit.edu	37	chr12	56091544	56091544	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gggtattggttcccatccatAtccaagctgcctgacaggga	11	11	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:56091544A>G	uc001shh.2	-	9	1576	c.1356T>C	c.(1354-1356)GAT>GAC	p.D452D	ITGA7_uc001shg.2_Silent_p.D448D|ITGA7_uc010sps.1_Silent_p.D355D|ITGA7_uc009znw.2_5'Flank|ITGA7_uc009znx.2_Silent_p.D335D	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	492	Potential.|FG-GAP 7.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						TCCCATCCATATCCAAGCTGC	0.607													0	0	0	0.021523	0	24	32										G	56091544	A	G	56091544	2	3	55	1	0	0	0	0	0	0	0	1	7881	446	16	5		5	ITGA7	12	56091544	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	2526331	56091544	77760351	216	16110										
CD63	967	broad.mit.edu	37	chr12	56120509	56120509	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cctgcatcctgtccaggatcGaagcagtgtggttgtttttc	11	10	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:56120509G>A	uc001shm.2	-	4	497	c.401C>T	c.(400-402)TCG>TTG	p.S134L	CD63_uc009znz.2_Missense_Mutation_p.S111L|CD63_uc001shn.2_Missense_Mutation_p.S134L|CD63_uc001sho.2_Missense_Mutation_p.S134L|CD63_uc001shp.2_Missense_Mutation_p.S134L	NM_001780	NP_001771	P08962	CD63_HUMAN	CD63 antigen isoform A	134	Extracellular (Potential).				platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane					0						GTCCAGGATCGAAGCAGTGTG	0.458													0	0	0	0.007291	0	31	34										A	56120509	G	A	56120509	3	1	55	1	0	0	0	0	1	0	0	0	3029	1059	37	1	331	1	CD63	12	56120509	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	28965	56120509	77731386	217	16111										
MBD6	114785	broad.mit.edu	37	chr12	57918588	57918589	+	Missense_Mutation	DNP	CC	CC	TT													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcaagtgcggtctggagtgtCcacttaatgtccccaaggtc							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:57918588_57918589CC>TT	uc001soj.1	+	4	423_424	c.199_200CC>TT	c.(199-201)CCA>TTA	p.P67L	MBD6_uc001sok.1_5'Flank|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	67	MBD.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						TCTGGAGTGTCCACTTAATGTC	0.545													0	0	0	0.004672	0	21	52										TT	57918589	CC	TT	57918588	3	4	55	1	0	0	0	0	1	0	0	0	9348	855	30	1	205	1	MBD6	12	57918588	Missense_Mutation	DNP	CC	TCGA-DK-A2I6-01A-12D-A18F-08	1798079	57918588	75933307	218	16112										
AGAP2	116986	broad.mit.edu	37	chr12	58121176	58121176	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcgagggcttggcacggcctCgcgtgtcgctttcccacacg	14	15	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:58121176C>T	uc001spq.2	-	17	3047	c.3047G>A	c.(3046-3048)CGA>CAA	p.R1016Q	AGAP2_uc001spo.1_5'Flank|AGAP2_uc001spp.2_Missense_Mutation_p.R1015Q|AGAP2_uc001spr.2_Missense_Mutation_p.R660Q|LOC100130776_uc001sps.3_Missense_Mutation_p.S134L	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	1016	Arf-GAP.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						GGCACGGCCTCGCGTGTCGCT	0.667													0	0	0	0.001984	0	7	11										T	58121176	C	T	58121176	3	4	55	1	0	0	0	0	1	0	0	0	368	884	31	1	543	1	AGAP2	12	58121176	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	202588	58121176	75730719	219	16113										
TMEM5	10329	broad.mit.edu	37	chr12	64199128	64199128	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcatccagacaggcactaatGaacattttgaaaaaagatgg	8	7	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:64199128G>A	uc001srq.1	+	5	962	c.858G>A	c.(856-858)ATG>ATA	p.M286I	TMEM5_uc001srr.1_Missense_Mutation_p.M183I|TMEM5_uc001srs.1_Missense_Mutation_p.M26I	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	286	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		AGGCACTAATGAACATTTTGA	0.368													0	0	0	0.01892	0	22	50										A	64199128	G	A	64199128	3	1	55	1	0	0	0	0	1	0	0	0	16171	1290	45	1	876	1	TMEM5	12	64199128	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	6077952	64199128	69652767	220	16114										
NAP1L1	4673	broad.mit.edu	37	chr12	76447574	76447574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tacaacccataatttctggtCcatcaaaagaaaagggatca	6	9	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:76447574C>T	uc001sxw.2	-	9	1158	c.746G>A	c.(745-747)GGA>GAA	p.G249E	NAP1L1_uc001sxv.2_Missense_Mutation_p.G207E|NAP1L1_uc001sxz.2_Missense_Mutation_p.G180E|NAP1L1_uc001sxx.2_Missense_Mutation_p.G249E|NAP1L1_uc001sxy.2_Missense_Mutation_p.G186E|NAP1L1_uc010sty.1_Missense_Mutation_p.G206E|NAP1L1_uc010stz.1_Missense_Mutation_p.G66E|NAP1L1_uc010sua.1_Missense_Mutation_p.G249E|NAP1L1_uc001syb.2_Missense_Mutation_p.G249E|NAP1L1_uc001sya.2_Missense_Mutation_p.G207E|NAP1L1_uc001syc.2_Missense_Mutation_p.G260E	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	249					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				AATTTCTGGTCCATCAAAAGA	0.323													0	0	0	0.00308	0	8	24										T	76447574	C	T	76447574	3	4	55	1	0	0	0	0	1	0	0	0	10156	855	30	1	457	1	NAP1L1	12	76447574	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	12248446	76447574	57404321	221	16115										
PPP1R12A	4659	broad.mit.edu	37	chr12	80328602	80328602	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agacggcgccatcgtcgaacTtcaccttggtcttctggcgc	11	14	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:80328602T>A	uc001syz.2	-	1	377	c.110A>T	c.(109-111)AAG>ATG	p.K37M	PPP1R12A_uc001sza.2_Missense_Mutation_p.K37M|PPP1R12A_uc010sud.1_Missense_Mutation_p.K37M|PPP1R12A_uc001szb.2_Missense_Mutation_p.K37M|PPP1R12A_uc001szc.2_Missense_Mutation_p.K37M	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	37						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						ATCGTCGAACTTCACCTTGGT	0.637													0	0	0	0.001168	0	5	3										A	80328602	T	A	80328602	3	1	55	1	0	0	0	0	1	0	0	0	12354	1609	56	5	3082	5	PPP1R12A	12	80328602	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	3881028	80328602	53523293	222	16116										
TMCC3	57458	broad.mit.edu	37	chr12	94965478	94965478	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcttgctggtggagctccagCttagaaatgcgagtctggca	13	9	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:94965478C>T	uc001tdj.2	-	4	1285	c.1167G>A	c.(1165-1167)AAG>AAA	p.K389K	TMCC3_uc001tdi.2_Silent_p.K358K	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	389	Potential.					integral to membrane				ovary(1)|skin(1)	2						GGAGCTCCAGCTTAGAAATGC	0.547													0	0	0	0.016522	0	22	58										T	94965478	C	T	94965478	2	4	55	1	0	0	0	0	0	0	0	1	15991	796	28	2		2	TMCC3	12	94965478	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	14636876	94965478	38886417	223	16117										
CDK17	5128	broad.mit.edu	37	chr12	96728597	96728597	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cggagtgtgagggatagcctTctcttaaattttttcatcct	9	8	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr12:96728597T>A	uc001tep.1	-	2	507	c.18A>T	c.(16-18)AGA>AGT	p.R6S	CDK17_uc009ztk.2_Missense_Mutation_p.R6S|CDK17_uc010svb.1_Intron	NM_002595	NP_002586	Q00537	CDK17_HUMAN	PCTAIRE protein kinase 2	6							ATP binding|cyclin-dependent protein kinase activity			ovary(3)|lung(2)|kidney(1)|central_nervous_system(1)	7						GGGATAGCCTTCTCTTAAATT	0.338													0	0	0	0.001168	0	5	14										A	96728597	T	A	96728597	3	1	55	1	0	0	0	0	1	0	0	0	3133	1780	62	5	1655	5	CDK17	12	96728597	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	1763119	96728597	37123298	224	16118										
SACS	26278	broad.mit.edu	37	chr13	23906653	23906653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aacccctcgcaactgaaaacGaaattcccttttttctgcac	4	14	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr13:23906653G>A	uc001uon.2	-	10	11951	c.11362C>T	c.(11362-11364)CGT>TGT	p.R3788C	SACS_uc001uoo.2_Missense_Mutation_p.R3641C|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3788					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AACTGAAAACGAAATTCCCTT	0.383													0	0	0	0.005443	0	28	48										A	23906653	G	A	23906653	3	1	55	1	0	0	0	0	1	0	0	0	13804	1058	37	1	2381	1	SACS	13	23906653	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		23906653	91263225	225	16119										
MTMR6	9107	broad.mit.edu	37	chr13	25827950	25827950	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttccaaggaagtttccaaacTggcatgaatgaatatgctca	8	8	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr13:25827950T>C	uc001uqf.3	-	11	1617	c.1298A>G	c.(1297-1299)CAG>CGG	p.Q433R	MTMR6_uc001uqe.1_Missense_Mutation_p.Q433R	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	433	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GTTTCCAAACTGGCATGAATG	0.408													0	0	0	0.016522	0	24	48										C	25827950	T	C	25827950	3	2	55	1	0	0	0	0	1	0	0	0	9947	1580	55	5	583	5	MTMR6	13	25827950	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	1921297	25827950	89341928	226	16120										
MTUS2	23281	broad.mit.edu	37	chr13	30077186	30077188	+	In_Frame_Del	DEL	AGA	AGA	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgttgagaaggaaacccaggAgaagaagagattgagccgaa							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr13:30077186_30077188delAGA	uc001usl.3	+	14	4041_4043	c.3983_3985delAGA	c.(3982-3987)GAGAAG>GAG	p.K1330del	MTUS2_uc001usm.3_In_Frame_Del_p.K299del|MTUS2_uc010aau.2_In_Frame_Del_p.K209del|MTUS2_uc010tdq.1_In_Frame_Del_p.K82del	NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	1320	Potential.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GAAACCCAGGAGAAGAAGAGATT	0.493																		7	60	---	---								-	30077188	AGA	-	30077186	7	5	55	1	0	1	0	1	0	0	0	0	9966	304	11	0	4095	0	MTUS2	13	30077186	In_Frame_Del	DEL	AGA	TCGA-DK-A2I6-01A-12D-A18F-08	4249236	30077186	85092692	227	16121										
KBTBD6	89890	broad.mit.edu	37	chr13	41706188	41706188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acaggcttcccgcacatattCcagctgtagcatgtcggagg	11	12	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr13:41706188C>T	uc001uxu.1	-	1	749	c.460G>A	c.(460-462)GAA>AAA	p.E154K	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.E88K|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	154							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CGCACATATTCCAGCTGTAGC	0.582													0	0	0	0.008871	0	17	23										T	41706188	C	T	41706188	3	4	55	1	0	0	0	0	1	0	0	0	7997	864	30	1	1568	1	KBTBD6	13	41706188	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	11629002	41706188	73463690	228	16122										
RNF219	79596	broad.mit.edu	37	chr13	79190511	79190511	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agtcccaaaatcctgtctttGgggaagaaaaacattctgat	8	8	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr13:79190511G>C	uc001vkw.1	-	6	1444	c.1385C>G	c.(1384-1386)CCA>CGA	p.P462R	uc001vku.1_RNA|RNF219_uc010afb.1_Missense_Mutation_p.P272R|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	462	Ser-rich.			P -> T (in Ref. 1; CAB66586).			zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TCCTGTCTTTGGGGAAGAAAA	0.333													0	0	0	0.008291	0	9	17										C	79190511	G	C	79190511	3	2	55	1	0	0	0	0	1	0	0	0	13482	1348	47	4	799	4	RNF219	13	79190511	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	37484323	79190511	35979367	229	16123										
GPR18	2841	broad.mit.edu	37	chr13	99908094	99908094	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggatgtgagctgttaaaaggGacaggttgatcttgattgtt	14	3	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr13:99908094G>C	uc001voe.3	-	3	534	c.33C>G	c.(31-33)GTC>GTG	p.V11V	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron|GPR18_uc010afv.2_Silent_p.V11V	NM_005292	NP_005283	Q14330	GPR18_HUMAN	G protein-coupled receptor 18	11	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	TGTTAAAAGGGACAGGTTGAT	0.323													0	0	0	0.020292	0	13	37										C	99908094	G	C	99908094	2	2	55	1	0	0	0	0	0	0	0	1	6675	1161	41	1		1	GPR18	13	99908094	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	20717583	99908094	15261784	230	16124										
OR11H4	390442	broad.mit.edu	37	chr14	20711591	20711591	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tattttctatactcagagctCccttgtcctctttttcacta	3	12	4	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:20711591C>G	uc010tld.1	+	1	641	c.641C>G	c.(640-642)TCC>TGC	p.S214C		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		ACTCAGAGCTCCCTTGTCCTC	0.443													0	0	0	0.008871	0	21	159										G	20711591	C	G	20711591	3	3	55	1	0	0	0	0	1	0	0	0	10928	855	30	1	643	1	OR11H4	14	20711591	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		20711591	86637949	231	16125										
ACIN1	22985	broad.mit.edu	37	chr14	23559767	23559767	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttctcgagcttcacgttccaGacgctgcctaagtagctcct	8	14	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:23559767G>A	uc001wit.3	-	3	782	c.454C>T	c.(454-456)CTG>TTG	p.L152L	ACIN1_uc010akg.2_Silent_p.L152L|ACIN1_uc010tnj.1_Silent_p.L152L	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	152	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCACGTTCCAGACGCTGCCTA	0.438													0	0	0	0.001984	0	7	47										A	23559767	G	A	23559767	2	1	55	1	0	0	0	0	0	0	0	1	142	933	33	1		1	ACIN1	14	23559767	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2848176	23559767	83789773	232	16126										
ARHGAP5	394	broad.mit.edu	37	chr14	32562941	32562941	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaaatgagtatcctattcaTagtaccccaaactgtcatga	7	9	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:32562941T>C	uc001wrl.2	+	2	3305	c.3066T>C	c.(3064-3066)CAT>CAC	p.H1022H	ARHGAP5_uc001wrm.2_Silent_p.H1022H|ARHGAP5_uc001wrn.2_Silent_p.H1022H|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1022					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATCCTATTCATAGTACCCCAA	0.403													0	0	0	0.003163	0	15	65										C	32562941	T	C	32562941	2	2	55	1	0	0	0	0	0	0	0	1	886	1403	49	5		5	ARHGAP5	14	32562941	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	9003174	32562941	74786599	233	16127										
AKAP6	9472	broad.mit.edu	37	chr14	33291834	33291834	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggttgacttcctataaaagCaatgaagatctctttagctg	8	7	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:33291834C>A	uc001wrq.2	+	13	4985	c.4815C>A	c.(4813-4815)AGC>AGA	p.S1605R		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1605	Ser-rich.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CCTATAAAAGCAATGAAGATC	0.428													1	0	0.000274275	0.004482	0.000298715	9	37										A	33291834	C	A	33291834	3	1	55	1	0	0	0	0	1	0	0	0	455	709	25	4	4861	4	AKAP6	14	33291834	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	728893	33291834	74057706	234	16128										
SYNE2	23224	broad.mit.edu	37	chr14	64457735	64457735	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atttggacatcaggctgaagAtggaagaatcccagaaggaa	12	6	1	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:64457735A>G	uc001xgm.2	+	21	2778	c.2548A>G	c.(2548-2550)ATG>GTG	p.M850V	SYNE2_uc001xgl.2_Missense_Mutation_p.M850V	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	850	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAGGCTGAAGATGGAAGAATC	0.413													0	0	0	0.011902	0	43	8										G	64457735	A	G	64457735	3	3	55	1	0	0	0	0	1	0	0	0	15443	333	12	5	2626	5	SYNE2	14	64457735	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	31165901	64457735	42891805	235	16129										
SPTB	6710	broad.mit.edu	37	chr14	65233430	65233430	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cccaggaactagacaaacgaGaccagagactgaccggggac	12	12	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:65233430G>A	uc001xht.2	-	31	6413	c.6359C>T	c.(6358-6360)TCT>TTT	p.S2120F	SPTB_uc001xhr.2_Intron|SPTB_uc001xhs.2_Intron|SPTB_uc001xhu.2_Missense_Mutation_p.S2120F|SPTB_uc010aqi.2_Intron	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2120					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGACAAACGAGACCAGAGACT	0.632													0	0	0	0.01441	0	126	35										A	65233430	G	A	65233430	3	1	55	1	0	0	0	0	1	0	0	0	15117	942	33	1	716	1	SPTB	14	65233430	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	775695	65233430	42116110	236	16130										
GTF2A1	2957	broad.mit.edu	37	chr14	81662522	81662522	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cctgttgttgtagaaccactGactgctgaggctgaaagata	11	8	0	5			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:81662522G>A	uc001xvf.1	-	6	974	c.542C>T	c.(541-543)TCA>TTA	p.S181L	GTF2A1_uc010atb.1_Missense_Mutation_p.S131L|GTF2A1_uc001xvg.1_Missense_Mutation_p.S142L	NM_015859	NP_056943	P52655	TF2AA_HUMAN	TFIIA alpha, p55 isoform 1	181					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)		TAGAACCACTGACTGCTGAGG	0.423													0	0	0	0.01441	0	55	21										A	81662522	G	A	81662522	3	1	55	1	0	0	0	0	1	0	0	0	6852	1294	45	1	604	1	GTF2A1	14	81662522	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	16429092	81662522	25687018	237	16131										
AK7	122481	broad.mit.edu	37	chr14	96949491	96949491	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggccagggaggctgctgagGaagcagaacgcgagcaccag	17	10	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:96949491G>A	uc001yfn.2	+	16	1953	c.1909G>A	c.(1909-1911)GAA>AAA	p.E637K		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	637	Potential.|Glu-rich.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GGCTGCTGAGGAAGCAGAACG	0.567													0	0	0	0.003163	0	16	8										A	96949491	G	A	96949491	3	1	55	1	0	0	0	0	1	0	0	0	444	1175	41	1	1971	1	AK7	14	96949491	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	15286969	96949491	10400049	238	16132										
HSP90AA1	3320	broad.mit.edu	37	chr14	102550300	102550300	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tagagggagatcctccgagtCtaccacccctctaatgaagt	9	12	2	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:102550300C>T	uc001yku.3	-	7	1358	c.1168G>A	c.(1168-1170)GAC>AAC	p.D390N	HSP90AA1_uc001ykv.3_Missense_Mutation_p.D512N|HSP90AA1_uc001ykw.1_Missense_Mutation_p.D211N|HSP90AA1_uc001ykx.1_Missense_Mutation_p.D379N	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	390					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	TCCTCCGAGTCTACCACCCCT	0.363													0	0	0	0.010504	0	19	10										T	102550300	C	T	102550300	3	4	55	1	0	0	0	0	1	0	0	0	7401	913	32	1	1050	1	HSP90AA1	14	102550300	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5600809	102550300	4799240	239	16133										
XRCC3	7517	broad.mit.edu	37	chr14	104174929	104174929	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgccagacctcggggctggaGaggttggtcagtctcttcaa	14	10	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr14:104174929G>A	uc001yny.3	-	5	503	c.123C>T	c.(121-123)CTC>CTT	p.L41L	XRCC3_uc001ynx.3_Silent_p.L41L|XRCC3_uc001ynz.3_Silent_p.L41L|XRCC3_uc001yoa.3_Silent_p.L41L|XRCC3_uc001yob.1_RNA	NM_005432	NP_005423	O43542	XRCC3_HUMAN	X-ray repair cross complementing protein 3	41					DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		CGGGGCTGGAGAGGTTGGTCA	0.507								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.014323	0	22	8										A	104174929	G	A	104174929	2	1	55	1	0	0	0	0	0	0	0	1	17451	929	33	1		1	XRCC3	14	104174929	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1624629	104174929	3174611	240	16134										
HERC2	8924	broad.mit.edu	37	chr15	28460863	28460863	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagctgagggcgccgcatacCtgcggcgtgagagcgatgct	17	11	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:28460863C>T	uc001zbj.2	-	39	6220	c.6114G>A	c.(6112-6114)CAG>CAA	p.Q2038Q		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2038					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGCCGCATACCTGCGGCGTGA	0.627													0	0	0	0.016522	0	23	24										T	28460863	C	T	28460863	2	4	55	1	0	0	0	0	0	0	0	1	7058	680	24	2		2	HERC2	15	28460863	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		28460863	74070529	241	16135										
APBA2	321	broad.mit.edu	37	chr15	29393827	29393827	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	catgatggaccacgccttgcGtaccatctcctacatcgccg	8	16	1	1	rs142481200		TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:29393827G>A	uc001zck.2	+	9	1571	c.1364G>A	c.(1363-1365)CGT>CAT	p.R455H	APBA2_uc010azj.2_Missense_Mutation_p.R443H|APBA2_uc010uat.1_Missense_Mutation_p.R443H|APBA2_uc001zcl.2_Missense_Mutation_p.R443H|APBA2_uc001zcm.1_Missense_Mutation_p.R147H	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	455	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CACGCCTTGCGTACCATCTCC	0.552													0	0	0	0.004482	0	8	15										A	29393827	G	A	29393827	3	1	55	1	0	0	0	0	1	0	0	0	757	1145	40	2	1390	2	APBA2	15	29393827	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	932964	29393827	73137565	242	16136										
DISP2	85455	broad.mit.edu	37	chr15	40660107	40660107	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgctgctggtctccggcctCaccacgagcgcggccttcta	11	17	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:40660107C>T	uc001zlk.1	+	8	1883	c.1794C>T	c.(1792-1794)CTC>CTT	p.L598L		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	598	Helical; (Potential).|SSD.				smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TCTCCGGCCTCACCACGAGCG	0.706													0	0	0	0.001168	0	6	4										T	40660107	C	T	40660107	2	4	55	1	0	0	0	0	0	0	0	1	4540	813	29	1		1	DISP2	15	40660107	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	11266280	40660107	61871285	243	16137										
LCMT2	9836	broad.mit.edu	37	chr15	43622469	43622469	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcggcctggggcgcgccaatCtgctccaaaaaagcgcgcac	13	15	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:43622469C>G	uc001zrg.2	-	1	423	c.219G>C	c.(217-219)CAG>CAC	p.Q73H	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	73					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GCGCGCCAATCTGCTCCAAAA	0.682													0	0	0	0.008871	0	19	11										G	43622469	C	G	43622469	3	3	55	1	0	0	0	0	1	0	0	0	8679	912	32	1	1845	1	LCMT2	15	43622469	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2962362	43622469	58908923	244	16138										
ODF3L1	161753	broad.mit.edu	37	chr15	76017546	76017546	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcttataccctgcatagccgGcactcagagaagcgtgagcg	12	12	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:76017546G>A	uc002bax.1	+	2	438	c.216G>A	c.(214-216)CGG>CGA	p.R72R		NM_175881	NP_787077	Q8IXM7	OD3L1_HUMAN	outer dense fiber of sperm tails 3-like 1	72											0						TGCATAGCCGGCACTCAGAGA	0.592													0	0	0	0.014758	0	4	58										A	76017546	G	A	76017546	2	1	55	1	0	0	0	0	0	0	0	1	10831	1190	42	2		2	ODF3L1	15	76017546	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	32395077	76017546	26513846	245	16139										
ARNT2	9915	broad.mit.edu	37	chr15	80845057	80845057	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cttatcccggcataactccgAtggaatcatcacatttgtgg	8	11	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:80845057A>G	uc002bfr.2	+	10	1197	c.1031A>G	c.(1030-1032)GAT>GGT	p.D344G	ARNT2_uc010unm.1_Missense_Mutation_p.D333G|ARNT2_uc002bfs.2_Missense_Mutation_p.D333G	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	344	PAS 2.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			CATAACTCCGATGGAATCATC	0.473													0	0	0	0.013114	0	46	28										G	80845057	A	G	80845057	3	3	55	1	0	0	0	0	1	0	0	0	966	333	12	5	1069	5	ARNT2	15	80845057	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	4827511	80845057	21686335	246	16140										
BTBD1	53339	broad.mit.edu	37	chr15	83710670	83710670	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctctctctaaaactgcacaGagtgtatctataggcaaaat	6	9	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:83710670G>C	uc002bjn.2	-	4	875	c.672C>G	c.(670-672)CTC>CTG	p.L224L	BTBD1_uc002bjo.2_Silent_p.L224L	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	224						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		AAACTGCACAGAGTGTATCTA	0.368													0	0	0	0.003163	0	13	12										C	83710670	G	C	83710670	2	2	55	1	0	0	0	0	0	0	0	1	1537	929	33	1		1	BTBD1	15	83710670	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2865613	83710670	18820722	247	16141										
RGMA	56963	broad.mit.edu	37	chr15	93588760	93588760	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggtggtgccgatgtacttgGcctggatctccacgtgctgg	15	10	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:93588760G>T	uc002bss.1	-	4	1093	c.821C>A	c.(820-822)GCC>GAC	p.A274D	RGMA_uc002bsq.1_Missense_Mutation_p.A258D|RGMA_uc010boi.1_Missense_Mutation_p.A165D|RGMA_uc002bsr.1_Missense_Mutation_p.A165D|RGMA_uc010urc.1_Missense_Mutation_p.A282D	NM_020211	NP_064596	Q96B86	RGMA_HUMAN	RGM domain family, member A precursor	274					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane					0	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GATGTACTTGGCCTGGATCTC	0.617													1	0	3.1745e-13	0.008361	3.63744e-13	27	9										T	93588760	G	T	93588760	3	4	55	1	0	0	0	0	1	0	0	0	13280	1203	42	4	535	4	RGMA	15	93588760	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	9878090	93588760	8942632	248	16142										
FAM169B	283777	broad.mit.edu	37	chr15	98995120	98995120	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcgtcctctgggaatgtctCacagaagtcccgcagcatgg	11	13	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr15:98995120C>T	uc002buk.1	-	5	554	c.304G>A	c.(304-306)GAG>AAG	p.E102K		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	102											0						GGGAATGTCTCACAGAAGTCC	0.572													0	0	0	0.020292	0	14	5										T	98995120	C	T	98995120	3	4	55	1	0	0	0	0	1	0	0	0	5488	835	29	1	286	1	FAM169B	15	98995120	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5406360	98995120	3536272	249	16143										
NLRC3	197358	broad.mit.edu	37	chr16	3613416	3613416	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	caggaacacgtccagcctccCgtcctctgcctgcatggccc	9	19	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:3613416C>G	uc010btn.2	-	5	1933	c.1522G>C	c.(1522-1524)GGG>CGG	p.G508R		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	508					I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TCCAGCCTCCCGTCCTCTGCC	0.667													0	0	0	0.004672	0	3	0										G	3613416	C	G	3613416	3	3	55	1	0	0	0	0	1	0	0	0	10468	652	23	4	1740	4	NLRC3	16	3613416	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		3613416	86741337	250	16144										
TMC7	79905	broad.mit.edu	37	chr16	19073098	19073101	+	Splice_Site	DEL	AGGA	AGGA	-													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atgtgaacttattattttttAggaaagtcgtgacaagtgct							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:19073098_19073101delAGGA	uc002dfq.2	+	16	2237	c.2107_splice	c.e16-1	p.E703_splice	TMC7_uc010vap.1_Splice_Site_p.E593_splice	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a							integral to membrane				skin(2)|ovary(1)	3						ATTATTTTTTAGGAAAGTCGTGAC	0.377																		8	8	---	---								-	19073101	AGGA	-	19073098	8	5	55	1	0	1	0	1	0	0	1	0	15987	434	15	0	2167	0	TMC7	16	19073098	Splice_Site	DEL	AGGA	TCGA-DK-A2I6-01A-12D-A18F-08	15459682	19073098	71281655	251	16145										
ZNF267	10308	broad.mit.edu	37	chr16	31927008	31927008	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atgctcgttcttcaaatcttAttatgcatcagagagttcat	6	8	5	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:31927008A>T	uc002ecs.3	+	4	1647	c.1438A>T	c.(1438-1440)ATT>TTT	p.I480F		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	480	C2H2-type 6.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						TTCAAATCTTATTATGCATCA	0.363													0	0	0	0.008291	0	11	56										T	31927008	A	T	31927008	3	4	55	1	0	0	0	0	1	0	0	0	17803	449	16	5	1452	5	ZNF267	16	31927008	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	12853910	31927008	58427745	252	16146										
ABCC12	94160	broad.mit.edu	37	chr16	48130786	48130786	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	attctcagcgcaaaccacctGagagcacagttaaagtagag	9	10	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:48130786G>A	uc002efc.1	-	22	3412	c.3066C>T	c.(3064-3066)CTC>CTT	p.L1022L	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1022	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CAAACCACCTGAGAGCACAGT	0.463													0	0	0	0.005443	0	24	40										A	48130786	G	A	48130786	2	1	55	1	0	0	0	0	0	0	0	1	52	1277	45	1		1	ABCC12	16	48130786	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	16203778	48130786	42223967	253	16147										
CDH16	1014	broad.mit.edu	37	chr16	66946442	66946442	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctcaggggcgtgatcattgaTatctgtgactgcgacttcga	12	9	3	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:66946442T>A	uc002eql.2	-	11	1397	c.1324A>T	c.(1324-1326)ATC>TTC	p.I442F	CDH16_uc010cdy.2_Missense_Mutation_p.I442F|CDH16_uc002eqm.2_Missense_Mutation_p.I345F	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	442	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TGATCATTGATATCTGTGACT	0.597													0	0	0	0.016723	0	12	47										A	66946442	T	A	66946442	3	1	55	1	0	0	0	0	1	0	0	0	3101	1406	49	5	1197	5	CDH16	16	66946442	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	18815656	66946442	23408311	254	16148										
ESRP2	80004	broad.mit.edu	37	chr16	68269814	68269814	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aagtcggtctcgtccgagccCaggtcccgtcccagcgcacc	11	18	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:68269814C>G	uc010cfa.1	-	1	323	c.135G>C	c.(133-135)CTG>CTC	p.L45L	ESRP2_uc002evq.1_Silent_p.L45L	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	45					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						CGTCCGAGCCCAGGTCCCGTC	0.502													0	0	0	0.008291	0	10	11										G	68269814	C	G	68269814	2	3	55	1	0	0	0	0	0	0	0	1	5259	581	21	4		4	ESRP2	16	68269814	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1323372	68269814	22084939	255	16149										
MTSS1L	92154	broad.mit.edu	37	chr16	70698173	70698173	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgcgcccgagggcaggccagTggccgtgggcagccccgcgg	19	15	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:70698173T>C	uc002ezj.2	-	15	1911	c.1651A>G	c.(1651-1653)ACT>GCT	p.T551A		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	551					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						GGCAGGCCAGTGGCCGTGGGC	0.746													0	0	0	0.004482	0	9	23										C	70698173	T	C	70698173	3	2	55	1	0	0	0	0	1	0	0	0	9963	1696	59	5	596	5	MTSS1L	16	70698173	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	2428359	70698173	19656580	256	16150										
CMIP	80790	broad.mit.edu	37	chr16	81712175	81712175	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cctgcagcaccatgagcatcGagctgggcccccaggccgac	12	17	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:81712175G>C	uc002fgp.2	+	10	1402	c.1330G>C	c.(1330-1332)GAG>CAG	p.E444Q	CMIP_uc002fgq.1_Missense_Mutation_p.E350Q|CMIP_uc010vnq.1_Missense_Mutation_p.E257Q|CMIP_uc002fgr.1_Missense_Mutation_p.E291Q	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	410						cytoplasm|nucleus					0						CATGAGCATCGAGCTGGGCCC	0.562													0	0	0	0.008291	0	8	9										C	81712175	G	C	81712175	3	2	55	1	0	0	0	0	1	0	0	0	3578	1059	37	1	1390	1	CMIP	16	81712175	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	11014002	81712175	8642578	257	16151										
ZDHHC7	55625	broad.mit.edu	37	chr16	85011581	85011581	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgaaatccacaaaggatcaGagcatggactgaagacagag	11	8	1	5			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:85011581G>C	uc002fiq.2	-	6	921	c.568C>G	c.(568-570)CTG>GTG	p.L190V	ZDHHC7_uc010voi.1_Missense_Mutation_p.L227V|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	190	Helical; (Potential).					integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						CAAAGGATCAGAGCATGGACT	0.378													0	0	0	0.01441	0	45	41										C	85011581	G	C	85011581	3	2	55	1	0	0	0	0	1	0	0	0	17617	933	33	1	370	1	ZDHHC7	16	85011581	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3299406	85011581	5343172	258	16152										
TCF25	22980	broad.mit.edu	37	chr16	89958628	89958628	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagagacaacgtgtgtacccCaagtgcacatggctgaccac	10	13	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr16:89958628C>T	uc002fpb.2	+	6	724	c.642C>T	c.(640-642)CCC>CCT	p.P214P	TCF25_uc002fpc.2_5'UTR	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	214					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		GTGTGTACCCCAAGTGCACAT	0.617													0	0	0	0.001168	0	4	21										T	89958628	C	T	89958628	2	4	55	1	0	0	0	0	0	0	0	1	15690	581	21	2		2	TCF25	16	89958628	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	4947047	89958628	396125	259	16153										
ZNF594	84622	broad.mit.edu	37	chr17	5086957	5086957	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtgaatttgcttatgtctcaCcagattggagctctgattga	10	7	2	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:5086957C>G	uc010cla.1	-	2	751	c.595G>C	c.(595-597)GTG>CTG	p.V199L		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	199	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTATGTCTCACCAGATTGGAG	0.393													0	0	0	0.00623	0	38	87										G	5086957	C	G	5086957	3	3	55	1	0	0	0	0	1	0	0	0	18021	507	18	4	1832	4	ZNF594	17	5086957	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		5086957	76108253	260	16154										
ZNF594	84622	broad.mit.edu	37	chr17	5087090	5087090	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccacattcattacacacataTggcttatttcctgtatgaat	4	10	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:5087090T>G	uc010cla.1	-	2	618	c.462A>C	c.(460-462)CCA>CCC	p.P154P		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TACACACATATGGCTTATTTC	0.303													0	0	0	0.016522	0	22	55										G	5087090	T	G	5087090	2	3	55	1	0	0	0	0	0	0	0	1	18021	1451	51	5		5	ZNF594	17	5087090	Silent	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	133	5087090	76108120	261	16155										
DHX33	56919	broad.mit.edu	37	chr17	5371895	5371895	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cggcgcggccactcaccgatGaggaccgcgttgtccaggtt	14	14	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:5371895G>A	uc002gca.2	-	1	287	c.285C>T	c.(283-285)CTC>CTT	p.L95L	DHX33_uc002gcb.2_5'UTR|DHX33_uc010clf.2_Silent_p.L95L	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	95	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						ACTCACCGATGAGGACCGCGT	0.612													0	0	0	0.001168	0	5	16										A	5371895	G	A	5371895	2	1	55	1	0	0	0	0	0	0	0	1	4506	1277	45	1		1	DHX33	17	5371895	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	284805	5371895	75823315	262	16156										
DLG4	1742	broad.mit.edu	37	chr17	7121570	7121570	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acctccttacctgactctctGagagggaagcctcataatag	8	12	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:7121570G>C	uc002get.3	-	3	1350	c.149C>G	c.(148-150)TCA>TGA	p.S50*	DLG4_uc010cly.2_5'Flank|DLG4_uc010vto.1_Nonsense_Mutation_p.S50*|DLG4_uc002geu.2_5'Flank|ACADVL_uc010vtp.1_Intron|ACADVL_uc010vtq.1_5'Flank|ACADVL_uc002gev.2_5'Flank|ACADVL_uc002gew.2_5'Flank|ACADVL_uc002gex.2_5'Flank	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						CTGACTCTCTGAGAGGGAAGC	0.552													0	0	0	0.016723	0	9	13										C	7121570	G	C	7121570	4	2	55	1	0	0	0	0	0	1	0	0	4557	1294	45	1	2268	1	DLG4	17	7121570	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1749675	7121570	74073640	263	16157										
TP53	7157	broad.mit.edu	37	chr17	7578500	7578500	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgtggaatcaacccacagctGcacagggcaggtcttggcca	12	12	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:7578500G>A	uc002gim.2	-	5	624	c.430C>T	c.(430-432)CAG>TAG	p.Q144*	TP53_uc002gig.1_Nonsense_Mutation_p.Q144*|TP53_uc002gih.2_Nonsense_Mutation_p.Q144*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q12*|TP53_uc010cng.1_Nonsense_Mutation_p.Q12*|TP53_uc002gii.1_Nonsense_Mutation_p.Q12*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q144*|TP53_uc010cni.1_Nonsense_Mutation_p.Q144*|TP53_uc002gij.2_Nonsense_Mutation_p.Q144*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.Q51*|TP53_uc002gio.2_Nonsense_Mutation_p.Q12*|TP53_uc010vug.1_Nonsense_Mutation_p.Q105*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	144	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q144*(29)|p.Q144L(8)|p.0?(7)|p.Q144H(4)|p.Q144P(4)|p.Q144R(4)|p.Q144fs*26(3)|p.Q144K(2)|p.Q144del(2)|p.Q144Q(2)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.Q144fs*32(1)|p.Q144fs*16(1)|p.P142_Q144delPVQ(1)|p.Q144fs*4(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACCCACAGCTGCACAGGGCAG	0.597		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.013726	0	32	39										A	7578500	G	A	7578500	4	1	55	1	0	0	0	0	0	1	0	0	16378	1328	46	2	868	2	TP53	17	7578500	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	456930	7578500	73616710	264	16158										
MYH3	4621	broad.mit.edu	37	chr17	10545784	10545784	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtgccaggagcctgttggaaGacttctggtacagcccaacc	12	12	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:10545784G>C	uc002gmq.1	-	15	1915	c.1838C>G	c.(1837-1839)TCT>TGT	p.S613C		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	613	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CCTGTTGGAAGACTTCTGGTA	0.542													0	0	0	0.01441	0	48	22										C	10545784	G	C	10545784	3	2	55	1	0	0	0	0	1	0	0	0	10036	942	33	1	4088	1	MYH3	17	10545784	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2967284	10545784	70649426	265	16159										
TMEM132E	124842	broad.mit.edu	37	chr17	32964390	32964390	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgcttcgcgcagagctaacCatcgctgagagctgccagaa	11	13	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:32964390C>T	uc002hif.2	+	10	2422	c.2094C>T	c.(2092-2094)ACC>ACT	p.T698T		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	698	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CAGAGCTAACCATCGCTGAGA	0.642													0	0	0	0.00308	0	7	47										T	32964390	C	T	32964390	2	4	55	1	0	0	0	0	0	0	0	1	16045	581	21	2		2	TMEM132E	17	32964390	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	22418606	32964390	48230820	266	16160										
DUSP14	11072	broad.mit.edu	37	chr17	35872428	35872428	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	actctcatggcccctcggatGatttccgagggagacatagg	12	11	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:35872428G>A	uc002hnx.2	+	3	348	c.54G>A	c.(52-54)ATG>ATA	p.M18I	DUSP14_uc002hny.2_Missense_Mutation_p.M5I|DUSP14_uc002hnz.2_Missense_Mutation_p.M5I	NM_007026	NP_008957	O95147	DUS14_HUMAN	dual specificity phosphatase 14	18							MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Breast(25;0.00637)|Ovarian(249;0.15)				CCCCTCGGATGATTTCCGAGG	0.577													0	0	0	0.01441	0	51	31										A	35872428	G	A	35872428	3	1	55	1	0	0	0	0	1	0	0	0	4814	1290	45	1	56	1	DUSP14	17	35872428	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2908038	35872428	45322782	267	16161										
ERBB2	2064	broad.mit.edu	37	chr17	37879903	37879903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggatctggcgcttttggcaCagtctacaaggtcagggcca	13	10	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:37879903C>T	uc002hso.2	+	18	2436	c.2198C>T	c.(2197-2199)ACA>ATA	p.T733I	ERBB2_uc002hsm.2_Missense_Mutation_p.T703I|ERBB2_uc010cwa.2_Missense_Mutation_p.T718I|ERBB2_uc002hsp.2_Missense_Mutation_p.T536I|ERBB2_uc010cwb.2_Missense_Mutation_p.T733I|ERBB2_uc010wek.1_Missense_Mutation_p.T457I	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	733	Cytoplasmic (Potential).|Protein kinase.|ATP (By similarity).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.T733I(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GCTTTTGGCACAGTCTACAAG	0.637		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.01441	0	103	7										T	37879903	C	T	37879903	3	4	55	1	0	0	0	0	1	0	0	0	5206	478	17	2	2268	2	ERBB2	17	37879903	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2007475	37879903	43315307	268	16162										
IKZF3	22806	broad.mit.edu	37	chr17	37947792	37947792	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcggaggaggttacctttctGagtaaaagatgccccacact	11	10	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:37947792G>A	uc002hsu.2	-	5	531	c.469C>T	c.(469-471)CAG>TAG	p.Q157*	IKZF3_uc002htd.2_Nonsense_Mutation_p.Q123*|IKZF3_uc010cwd.2_Intron|IKZF3_uc002hsv.2_Nonsense_Mutation_p.Q123*|IKZF3_uc010cwe.2_Intron|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Nonsense_Mutation_p.Q157*|IKZF3_uc002hsx.2_Intron|IKZF3_uc002hsy.2_Nonsense_Mutation_p.Q157*|IKZF3_uc002hsz.2_Intron|IKZF3_uc002hta.2_Nonsense_Mutation_p.Q157*|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Nonsense_Mutation_p.Q70*|IKZF3_uc002htc.2_Intron	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	157	C2H2-type 2.				B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TTACCTTTCTGAGTAAAAGAT	0.448													0	0	0	0.01441	0	809	81										A	37947792	G	A	37947792	4	1	55	1	0	0	0	0	0	1	0	0	7616	1299	45	1	1076	1	IKZF3	17	37947792	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	67889	37947792	43247418	269	16163										
STH	246744	broad.mit.edu	37	chr17	44076789	44076789	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gttgccagagacagaaccctCagcttagcatgggaagtagc	12	10	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:44076789C>T	uc002ijy.2	+	1	174	c.144C>T	c.(142-144)CTC>CTT	p.L48L	MAPT_uc010dau.2_Intron|MAPT_uc002ijr.3_Intron|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_001007532	NP_001007533	Q8IWL8	STH_HUMAN	saitohin	48						cytoplasm|nucleus					0						ACAGAACCCTCAGCTTAGCAT	0.418													0	0	0	0.004482	0	9	38										T	44076789	C	T	44076789	2	4	55	1	0	0	0	0	0	0	0	1	15280	813	29	1		1	STH	17	44076789	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	6128997	44076789	37118421	270	16164										
ITGA3	3675	broad.mit.edu	37	chr17	48153806	48153806	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctggacgcctacccgatcctCaaccaggcacaggctctgga	10	16	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:48153806C>T	uc010dbl.2	+	13	2255	c.1791C>T	c.(1789-1791)CTC>CTT	p.L597L	ITGA3_uc010dbm.2_Silent_p.L597L	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	597	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						ACCCGATCCTCAACCAGGCAC	0.647													0	0	0	0.010818	0	32	160										T	48153806	C	T	48153806	2	4	55	1	0	0	0	0	0	0	0	1	7877	813	29	1		1	ITGA3	17	48153806	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	4077017	48153806	33041404	271	16165										
SAMD14	201191	broad.mit.edu	37	chr17	48190393	48190393	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcaccagtgcccggtcatgaGagttgctgagccccaggctc	12	14	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:48190393G>A	uc002iqg.2	-	10	1417	c.1118C>T	c.(1117-1119)TCT>TTT	p.S373F	SAMD14_uc002iqd.2_Missense_Mutation_p.S156F|SAMD14_uc002iqe.2_Missense_Mutation_p.S156F|SAMD14_uc002iqf.2_Missense_Mutation_p.S401F	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	373	SAM.										0						CCGGTCATGAGAGTTGCTGAG	0.657													0	0	0	0.001984	0	6	33										A	48190393	G	A	48190393	3	1	55	1	0	0	0	0	1	0	0	0	13819	942	33	1	139	1	SAMD14	17	48190393	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	36587	48190393	33004817	272	16166										
CHAD	1101	broad.mit.edu	37	chr17	48545626	48545626	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gccccgggctgcagggagctCaacgcgttttccgacaggta	14	13	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:48545626C>T	uc010dbr.2	-	1	602	c.549G>A	c.(547-549)TTG>TTA	p.L183L	ACSF2_uc002iqu.2_Intron|ACSF2_uc010wml.1_Intron|ACSF2_uc010wmm.1_Intron|ACSF2_uc010wmn.1_Intron|ACSF2_uc010wmo.1_Intron|CHAD_uc010dbs.2_Silent_p.L183L|ACSF2_uc010dbt.1_5'Flank	NM_001267	NP_001258	O15335	CHAD_HUMAN	chondroadherin precursor	183	LRR 5.				regulation of cell growth	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(2)|central_nervous_system(1)	3	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			GCAGGGAGCTCAACGCGTTTT	0.622													0	0	0	0.016723	0	12	114										T	48545626	C	T	48545626	2	4	55	1	0	0	0	0	0	0	0	1	3310	825	29	1		1	CHAD	17	48545626	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	355233	48545626	32649584	273	16167										
AXIN2	8313	broad.mit.edu	37	chr17	63533517	63533517	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agtagcagtaatactcgctgCccccagggcagaagcagtgc	12	12	0	1	rs145717795	byFrequency	TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:63533517C>T	uc002jfi.2	-	6	1926	c.1637G>A	c.(1636-1638)GGC>GAC	p.G546D	AXIN2_uc002jfh.2_Missense_Mutation_p.G546D	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	546					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						ATACTCGCTGCCCCCAGGGCA	0.612									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				0	0	0	0.006214	0	10	110										T	63533517	C	T	63533517	3	4	55	1	0	0	0	0	1	0	0	0	1237	739	26	2	918	2	AXIN2	17	63533517	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	14987891	63533517	17661693	274	16168										
CBX4	8535	broad.mit.edu	37	chr17	77808682	77808682	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccgttcttgttcttgttcttGactatcttcatcttgccccc	5	14	6	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr17:77808682G>C	uc002jxe.2	-	5	922	c.759C>G	c.(757-759)GTC>GTG	p.V253V		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	253	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCTTGTTCTTGACTATCTTCA	0.577											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	130	164										C	77808682	G	C	77808682	2	2	55	1	0	0	0	0	0	0	0	1	2720	1277	45	1		1	CBX4	17	77808682	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	14275165	77808682	3386528	275	16169										
LPIN2	9663	broad.mit.edu	37	chr18	2954522	2954522	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atattcttcttcagtctcctCaacaaagaaagcttctccgt	4	12	6	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr18:2954522C>T	uc002klo.2	-	3	507	c.268G>A	c.(268-270)GAG>AAG	p.E90K		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	90	N-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		TCAGTCTCCTCAACAAAGAAA	0.453													0	0	0	0.007413	0	18	23										T	2954522	C	T	2954522	3	4	55	1	0	0	0	0	1	0	0	0	8919	835	29	1	2494	1	LPIN2	18	2954522	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		2954522	75122726	276	16170										
ABHD3	171586	broad.mit.edu	37	chr18	19231568	19231568	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	catgttaagagagttcatgtCcatgctcaaccatggcttgc	9	10	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr18:19231568C>A	uc002ktl.2	-	9	1354	c.1214G>T	c.(1213-1215)GGA>GTA	p.G405V	ABHD3_uc002ktm.2_Missense_Mutation_p.G352V|ABHD3_uc002ktk.2_Missense_Mutation_p.G210V	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	405						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						GAGTTCATGTCCATGCTCAAC	0.423													1	0	7.41606e-26	0.01441	8.65534e-26	58	46										A	19231568	C	A	19231568	3	1	55	1	0	0	0	0	1	0	0	0	83	855	30	3	19	3	ABHD3	18	19231568	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	16277046	19231568	58845680	277	16171										
MIB1	57534	broad.mit.edu	37	chr18	19359586	19359586	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgagactttaactacaactgGaactgtttgtggcattgatg	10	6	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr18:19359586G>C	uc002ktq.2	+	6	848	c.848G>C	c.(847-849)GGA>GCA	p.G283A	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	283					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			ACTACAACTGGAACTGTTTGT	0.388													0	0	0	0.01441	0	75	88										C	19359586	G	C	19359586	3	2	55	1	0	0	0	0	1	0	0	0	9566	1174	41	1	870	1	MIB1	18	19359586	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	128018	19359586	58717662	278	16172										
C18orf34	374864	broad.mit.edu	37	chr18	30903591	30903591	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	attaacttttctgtgtaggtCcattacctagaaatgaaaat	6	6	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr18:30903591C>T	uc002kxn.2	-	10	1028	c.886G>A	c.(886-888)GAC>AAC	p.D296N	C18orf34_uc010xbr.1_Missense_Mutation_p.D296N|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.D296N|C18orf34_uc002kxp.2_Missense_Mutation_p.D296N	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	296	Potential.									ovary(1)	1						CTGTGTAGGTCCATTACCTAG	0.294													0	0	0	0.009096	0	4	2										T	30903591	C	T	30903591	3	4	55	1	0	0	0	0	1	0	0	0	1902	855	30	1	1769	1	C18orf34	18	30903591	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	11544005	30903591	47173657	279	16173										
MALT1	10892	broad.mit.edu	37	chr18	56348424	56348424	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcctagacctggagcagtgtTctcttaaggtactggagcct	12	10	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr18:56348424T>C	uc002lhm.1	+	2	490	c.232T>C	c.(232-234)TCT>CCT	p.S78P	MALT1_uc002lhn.1_Missense_Mutation_p.S78P	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	78	Death.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						GGAGCAGTGTTCTCTTAAGGT	0.463			T	BIRC3	MALT								0	0	0	0.010771	0	36	21										C	56348424	T	C	56348424	3	2	55	1	0	0	0	0	1	0	0	0	9202	1783	62	5	238	5	MALT1	18	56348424	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	25444833	56348424	21728824	280	16174										
ATP8B3	148229	broad.mit.edu	37	chr19	1796870	1796870	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcgaacttgttccagaggtaGgggttctcctgggggtggcg	18	8	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:1796870G>C	uc002ltw.2	-	16	1827	c.1593C>G	c.(1591-1593)CCC>CCG	p.P531P	ATP8B3_uc002ltv.2_Silent_p.P484P|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	531	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCAGAGGTAGGGGTTCTCCT	0.716													0	0	0	0.004672	0	3	22										C	1796870	G	C	1796870	2	2	55	1	0	0	0	0	0	0	0	1	1196	987	35	4		4	ATP8B3	19	1796870	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		1796870	57332113	281	16175										
STAP2	55620	broad.mit.edu	37	chr19	4338736	4338736	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ttggggacacggggtggcctCagggcagaggccatgacgga	19	9	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:4338736C>T	uc002mab.2	-	1	112	c.15G>A	c.(13-15)CTG>CTA	p.L5L	STAP2_uc002mac.2_Silent_p.L5L|STAP2_uc002mad.2_5'UTR	NM_001013841	NP_001013863	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	5						cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGTGGCCTCAGGGCAGAGG	0.627													0	0	0	0.010729	0	9	26										T	4338736	C	T	4338736	2	4	55	1	0	0	0	0	0	0	0	1	15252	813	29	1		1	STAP2	19	4338736	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2541866	4338736	54790247	282	16176										
VAV1	7409	broad.mit.edu	37	chr19	6836572	6836572	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggctgaggctgaacagaactGgtgggaggtacaggctgggg	20	6	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:6836572G>A	uc002mfu.1	+	20	2004	c.1907G>A	c.(1906-1908)TGG>TAG	p.W636*	VAV1_uc010xjh.1_Nonsense_Mutation_p.W604*|VAV1_uc010dva.1_Nonsense_Mutation_p.W636*|VAV1_uc002mfv.1_Nonsense_Mutation_p.W581*	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	636	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						GAACAGAACTGGTGGGAGGTA	0.567													0	0	0	0.00308	0	7	24										A	6836572	G	A	6836572	4	1	55	1	0	0	0	0	0	1	0	0	17128	1357	47	2	1985	2	VAV1	19	6836572	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2497836	6836572	52292411	283	16177										
ANGPTL4	51129	broad.mit.edu	37	chr19	8431173	8431173	+	Missense_Mutation	SNP	G	G	A													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccgagatggcccagccagttGacccggctcacaatgtcagc							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:8431173G>A	uc002mjq.1	+	3	712	c.517G>A	c.(517-519)GAC>AAC	p.D173N	ANGPTL4_uc002mjr.1_Missense_Mutation_p.D173N|ANGPTL4_uc010xkc.1_Missense_Mutation_p.D6N	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	173					angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						CCAGCCAGTTGACCCGGCTCA	0.637													0	0	0	0.008871	0	18	32										A	8431173	G	A	8431173	3	1	55	1	0	0	0	0	1	0	0	0	616	1290	45	1	527	1	ANGPTL4	19	8431173	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1594601	8431173	50697810	284	16178	81	2								
ANGPTL4	51129	broad.mit.edu	37	chr19	8431175	8431175	+	Missense_Mutation	SNP	C	C	A													0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagatggcccagccagttgaCccggctcacaatgtcagccg							TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:8431175C>A	uc002mjq.1	+	3	714	c.519C>A	c.(517-519)GAC>GAA	p.D173E	ANGPTL4_uc002mjr.1_Missense_Mutation_p.D173E|ANGPTL4_uc010xkc.1_Missense_Mutation_p.D6E	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	173					angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						AGCCAGTTGACCCGGCTCACA	0.632													1	0	1.33834e-09	0.007413	1.5138e-09	18	32										A	8431175	C	A	8431175	3	1	55	1	0	0	0	0	1	0	0	0	616	506	18	4	529	4	ANGPTL4	19	8431175	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	2	8431175	50697808	285	16179	81	2								
MUC16	94025	broad.mit.edu	37	chr19	9076683	9076683	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgacagtccaggaatctgatGcagctgtggaagaccaggtg	14	8	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:9076683G>T	uc002mkp.2	-	3	10967	c.10763C>A	c.(10762-10764)GCA>GAA	p.A3588E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3589	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAATCTGATGCAGCTGTGGA	0.493													1	0	0.00116845	0.001168	0.00126318	6	76										T	9076683	G	T	9076683	3	4	55	1	0	0	0	0	1	0	0	0	9973	1319	46	4	33088	4	MUC16	19	9076683	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	645508	9076683	50052300	286	16180										
MYO9B	4650	broad.mit.edu	37	chr19	17321180	17321180	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gggttttcgtctccctatgaGggggtcctggtatgtacgcg	15	9	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:17321180G>A	uc010eak.2	+	37	5939	c.5787G>A	c.(5785-5787)GAG>GAA	p.E1929E	MYO9B_uc002nfi.2_Silent_p.E1929E|MYO9B_uc002nfj.1_Intron|MYO9B_uc002nfm.1_Silent_p.E89E	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1929	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CTCCCTATGAGGGGGTCCTGG	0.627													0	0	0	0.00308	0	8	6										A	17321180	G	A	17321180	2	1	55	1	0	0	0	0	0	0	0	1	10085	991	35	2		2	MYO9B	19	17321180	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	8244497	17321180	41807803	287	16181										
KCNN1	3780	broad.mit.edu	37	chr19	18092569	18092569	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggcgcatcgccatgacctgcGagcgcgtgttcctcatctcg	12	15	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:18092569G>A	uc002nht.2	+	5	860	c.550G>A	c.(550-552)GAG>AAG	p.E184K	KCNN1_uc010xqa.1_Missense_Mutation_p.E184K	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	184	Helical; Name=Segment S3; (Potential).				synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						CATGACCTGCGAGCGCGTGTT	0.662													0	0	0	0.004007	0	16	20										A	18092569	G	A	18092569	3	1	55	1	0	0	0	0	1	0	0	0	8078	1059	37	1	560	1	KCNN1	19	18092569	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	771389	18092569	41036414	288	16182										
KIAA1683	80726	broad.mit.edu	37	chr19	18377736	18377736	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gcaggaggggggacgactggGgtctgcagaggaccagattg	20	7	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:18377736G>A	uc002nin.2	-	3	830	c.614C>T	c.(613-615)CCC>CTC	p.P205L	KIAA1683_uc010ebn.2_Missense_Mutation_p.P205L|KIAA1683_uc010xqe.1_Missense_Mutation_p.P159L	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	205						mitochondrion				ovary(2)	2						GGACGACTGGGGTCTGCAGAG	0.642													0	0	0	0.004482	0	9	29										A	18377736	G	A	18377736	3	1	55	1	0	0	0	0	1	0	0	0	8251	1232	43	2	3497	2	KIAA1683	19	18377736	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	285167	18377736	40751247	289	16183										
ZNF99	7652	broad.mit.edu	37	chr19	22941314	22941314	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctcatgttttctaagggctGaaaaattgctaaaagctttg	8	6	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:22941314G>A	uc010xrh.1	-	5	1124	c.1124C>T	c.(1123-1125)TCA>TTA	p.S375L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTAAGGGCTGAAAAATTGCT	0.358													0	0	0	0.00308	0	8	27										A	22941314	G	A	22941314	3	1	55	1	0	0	0	0	1	0	0	0	18201	1294	45	1	2000	1	ZNF99	19	22941314	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	4563578	22941314	36187669	290	16184										
GPI	2821	broad.mit.edu	37	chr19	34884959	34884959	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tacctgcaccgctttgctgcGtacttccagcaggtaccagc	9	15	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:34884959G>T	uc002nvg.1	+	12	1153	c.1050G>T	c.(1048-1050)GCG>GCT	p.A350A	GPI_uc002nvf.2_Silent_p.A389A|GPI_uc010xrv.1_Silent_p.A361A|GPI_uc010xrw.1_Silent_p.A322A|GPI_uc010edl.1_Silent_p.A350A|GPI_uc002nvi.1_Silent_p.A13A	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	350					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					GCTTTGCTGCGTACTTCCAGC	0.582													1	0	0.00185496	0.016723	0.00200044	13	30										T	34884959	G	T	34884959	2	4	55	1	0	0	0	0	0	0	0	1	6611	1132	40	4		4	GPI	19	34884959	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	11943645	34884959	24244024	291	16185										
GRAMD1A	57655	broad.mit.edu	37	chr19	35505212	35505212	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cagcctgacgggcccaccacCctgggccccttggatctgct	11	18	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:35505212C>T	uc010xse.1	+	10	1127	c.990C>T	c.(988-990)ACC>ACT	p.T330T	GRAMD1A_uc002nxi.1_Silent_p.T417T|GRAMD1A_uc002nxk.2_Silent_p.T323T|GRAMD1A_uc002nxl.2_Silent_p.T96T|GRAMD1A_uc010xsf.1_Silent_p.T335T|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_5'Flank	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	330						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGCCCACCACCCTGGGCCCCT	0.637													0	0	0	0.006999	0	32	63										T	35505212	C	T	35505212	2	4	55	1	0	0	0	0	0	0	0	1	6747	610	22	2		2	GRAMD1A	19	35505212	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	620253	35505212	23623771	292	16186										
UPK1A	11045	broad.mit.edu	37	chr19	36157752	36157752	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agcggaggccgagaagggatCtccagttgtggtgggcctgc	18	9	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:36157752C>T	uc002oaw.2	+	1	38	c.38C>T	c.(37-39)TCT>TTT	p.S13F	UPK1A_uc010eeh.2_Missense_Mutation_p.S13F	NM_007000	NP_008931	O00322	UPK1A_HUMAN	uroplakin 1A	13	Cytoplasmic (Potential).				epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGAAGGGATCTCCAGTTGTG	0.622													0	0	0	0.016522	0	24	52										T	36157752	C	T	36157752	3	4	55	1	0	0	0	0	1	0	0	0	17004	913	32	1	40	1	UPK1A	19	36157752	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	652540	36157752	22971231	293	16187										
ZFP14	57677	broad.mit.edu	37	chr19	36832186	36832186	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	taagtgttgagcgacgaataAaggtcttcctacactcctta	8	9	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:36832186A>C	uc002odx.1	-	4	635	c.542T>G	c.(541-543)TTT>TGT	p.F181C	ZFP14_uc010xtd.1_Missense_Mutation_p.F182C|ZFP14_uc010eex.1_Missense_Mutation_p.F181C	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	181	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					GCGACGAATAAAGGTCTTCCT	0.403													0	0	0	0.01892	0	24	52										C	36832186	A	C	36832186	3	2	55	1	0	0	0	0	1	0	0	0	17636	14	1	5	1063	5	ZFP14	19	36832186	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	674434	36832186	22296797	294	16188										
ZNF571	51276	broad.mit.edu	37	chr19	38055989	38055989	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tttccacattccttacattcAaagggtttctcacctgtatg	5	11	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:38055989A>G	uc002ogt.2	-	4	1442	c.1341T>C	c.(1339-1341)TTT>TTC	p.F447F	uc002ogm.2_Intron|uc002ogn.2_Intron|ZNF540_uc002ogo.2_Intron|ZNF540_uc002ogp.2_Intron|ZNF540_uc002ogq.2_Intron|ZNF571_uc002ogr.1_Intron|uc002ogs.1_5'Flank|ZNF571_uc010efp.2_Silent_p.F447F	NM_016536	NP_057620	Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	447	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCTTACATTCAAAGGGTTTCT	0.388													0	0	0	0.001984	0	6	203										G	38055989	A	G	38055989	2	3	55	1	0	0	0	0	0	0	0	1	18000	127	5	5		5	ZNF571	19	38055989	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	1223803	38055989	21072994	295	16189										
YIF1B	90522	broad.mit.edu	37	chr19	38800271	38800271	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccggctgggacacagggatcCtccgcttcgaggctgcaagg	15	13	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:38800271C>A	uc002ohz.2	-	2	120	c.71G>T	c.(70-72)AGG>ATG	p.R24M	YIF1B_uc002ohw.2_Translation_Start_Site|YIF1B_uc002ohx.2_Missense_Mutation_p.R9M|YIF1B_uc010xtx.1_Missense_Mutation_p.R7M|YIF1B_uc010xty.1_Translation_Start_Site|YIF1B_uc002oia.2_Missense_Mutation_p.R21M|YIF1B_uc002ohy.2_Missense_Mutation_p.R21M|YIF1B_uc002oib.2_Missense_Mutation_p.R21M	NM_001039672	NP_001034761	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B isoform 5	24	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CACAGGGATCCTCCGCTTCGA	0.632													1	0	0.000157383	0.00308	0.000171833	5	82										A	38800271	C	A	38800271	3	1	55	1	0	0	0	0	1	0	0	0	17473	681	24	4	982	4	YIF1B	19	38800271	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	744282	38800271	20328712	296	16190										
ITPKC	80271	broad.mit.edu	37	chr19	41223370	41223370	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtagagaccgagaggcccaaGcaaaagacggagccagacag	14	10	0	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:41223370G>A	uc002oot.2	+	1	363	c.330G>A	c.(328-330)AAG>AAA	p.K110K	ADCK4_uc002ooq.1_5'Flank|ADCK4_uc002oor.2_5'Flank|ADCK4_uc002oos.2_5'Flank	NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	110						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGAGGCCCAAGCAAAAGACGG	0.622													0	0	0	0.00499	0	18	43										A	41223370	G	A	41223370	2	1	55	1	0	0	0	0	0	0	0	1	7919	962	34	2		2	ITPKC	19	41223370	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2423099	41223370	17905613	297	16191										
ARHGEF1	9138	broad.mit.edu	37	chr19	42410644	42410644	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	agcttctgtttccggcggagGaagacaatggggcggggcct	17	9	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:42410644G>A	uc002orx.2	+	27	2636	c.2527G>A	c.(2527-2529)GAA>AAA	p.E843K	ARHGEF1_uc002ory.2_Missense_Mutation_p.E810K|ARHGEF1_uc002orz.2_Missense_Mutation_p.E681K|ARHGEF1_uc002osa.2_Missense_Mutation_p.E858K|ARHGEF1_uc002osb.2_Intron|ARHGEF1_uc002osc.2_Intron|ARHGEF1_uc002osd.2_Missense_Mutation_p.E502K|ARHGEF1_uc002ose.2_Missense_Mutation_p.E287K	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	843					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		TCCGGCGGAGGAAGACAATGG	0.677													0	0	0	0.01892	0	22	38										A	42410644	G	A	42410644	3	1	55	1	0	0	0	0	1	0	0	0	893	1175	41	1	2678	1	ARHGEF1	19	42410644	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1187274	42410644	16718339	298	16192										
PHLDB3	653583	broad.mit.edu	37	chr19	44008260	44008260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcccctcctcggggctgcttCgcgtccccatggccgctggg	13	18	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:44008260C>T	uc002own.3	-	2	270	c.11G>A	c.(10-12)CGA>CAA	p.R4Q	PHLDB3_uc002owo.2_Missense_Mutation_p.R4Q	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	4											0		Prostate(69;0.0153)				GGGGCTGCTTCGCGTCCCCAT	0.756													0	0	0	0.020292	0	14	6										T	44008260	C	T	44008260	3	4	55	1	0	0	0	0	1	0	0	0	11853	884	31	1	1971	1	PHLDB3	19	44008260	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	1597616	44008260	15120723	299	16193										
ZNF45	7596	broad.mit.edu	37	chr19	44418655	44418655	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgtgaacgccaactgaagctCttcccacactcttcacactt	5	16	3	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:44418655C>G	uc002oxu.1	-	4	1032	c.933G>C	c.(931-933)AAG>AAC	p.K311N	ZNF45_uc002oxw.1_Missense_Mutation_p.K311N|ZNF45_uc002oxv.1_Missense_Mutation_p.K311N	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	311	C2H2-type 6.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AACTGAAGCTCTTCCCACACT	0.468													0	0	0	0.003163	0	16	47										G	44418655	C	G	44418655	3	3	55	1	0	0	0	0	1	0	0	0	17918	912	32	1	1119	1	ZNF45	19	44418655	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	410395	44418655	14710328	300	16194										
ERCC2	2068	broad.mit.edu	37	chr19	45867774	45867774	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tggggtccaggaggtagtggTagctataaaccaccacattg	13	8	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:45867774T>C	uc002pbj.2	-	8	673	c.626A>G	c.(625-627)TAC>TGC	p.Y209C	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.Y131C|ERCC2_uc002pbk.2_Missense_Mutation_p.Y185C|ERCC2_uc002pbl.3_Missense_Mutation_p.Y185C|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	209	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GAGGTAGTGGTAGCTATAAAC	0.632			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.020292	0	14	39										C	45867774	T	C	45867774	3	2	55	1	0	0	0	0	1	0	0	0	5213	1638	57	5	1777	5	ERCC2	19	45867774	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	1449119	45867774	13261209	301	16195										
LMTK3	114783	broad.mit.edu	37	chr19	49005723	49005723	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgtgggaatgcaggtgcgccAgcccgcgggcgatctccagg	17	12	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:49005723A>G	uc002pjk.2	-	8	848	c.848T>C	c.(847-849)CTG>CCG	p.L283P		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CAGGTGCGCCAGCCCGCGGGC	0.711													0	0	0	0.010729	0	11	70										G	49005723	A	G	49005723	3	3	55	1	0	0	0	0	1	0	0	0	8860	188	7	5	3657	5	LMTK3	19	49005723	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	3137949	49005723	10123260	302	16196										
PTH2	113091	broad.mit.edu	37	chr19	49925885	49925885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgggatccgcccaggcccgtCctggggggcggaggctgtgg	20	13	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:49925885C>T	uc002pnn.1	-	2	245	c.143G>A	c.(142-144)GGA>GAA	p.G48E		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	48					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		CCAGGCCCGTCCTGGGGGGCG	0.756													0	0	0	0.014758	0	5	6										T	49925885	C	T	49925885	3	4	55	1	0	0	0	0	1	0	0	0	12759	855	30	1	163	1	PTH2	19	49925885	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	920162	49925885	9203098	303	16197										
FUZ	80199	broad.mit.edu	37	chr19	50311871	50311871	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acggtgaagaggcagcgcttCagttccaggtggaggagcag	17	8	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:50311871C>T	uc002ppq.1	-	9	1023	c.918G>A	c.(916-918)CTG>CTA	p.L306L	FUZ_uc002ppr.1_Silent_p.L206L|FUZ_uc002pps.1_RNA|FUZ_uc002ppt.1_RNA|FUZ_uc002ppu.1_Silent_p.L270L|FUZ_uc002ppv.1_Silent_p.L256L	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	306	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		GGCAGCGCTTCAGTTCCAGGT	0.657													0	0	0	0.020292	0	13	13										T	50311871	C	T	50311871	2	4	55	1	0	0	0	0	0	0	0	1	6112	813	29	1		1	FUZ	19	50311871	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	385986	50311871	8817112	304	16198										
FUZ	80199	broad.mit.edu	37	chr19	50312751	50312751	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccccagccgccaccaaccctCtgttgctgccaccacccggc	7	23	1	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr19:50312751C>T	uc002ppq.1	-	6	679	c.574G>A	c.(574-576)GAG>AAG	p.E192K	FUZ_uc002ppr.1_Missense_Mutation_p.E92K|FUZ_uc002pps.1_RNA|FUZ_uc002ppt.1_RNA|FUZ_uc002ppu.1_Missense_Mutation_p.E156K|FUZ_uc002ppv.1_Missense_Mutation_p.E142K	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	192					cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		CACCAACCCTCTGTTGCTGCC	0.721													0	0	0	0.009096	0	4	11										T	50312751	C	T	50312751	3	4	55	1	0	0	0	0	1	0	0	0	6112	922	32	1	706	1	FUZ	19	50312751	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	880	50312751	8816232	305	16199										
CDC25B	994	broad.mit.edu	37	chr20	3781635	3781635	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	caggatggatttgtcttcaaGatgccatggaagcccacaca	10	10	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr20:3781635G>A	uc002wjn.2	+	7	1378	c.600G>A	c.(598-600)AAG>AAA	p.K200K	CDC25B_uc010zqk.1_Silent_p.K136K|CDC25B_uc010zql.1_Silent_p.K122K|CDC25B_uc010zqm.1_Silent_p.K136K|CDC25B_uc002wjl.2_Silent_p.K88K|CDC25B_uc002wjm.2_Silent_p.K88K|CDC25B_uc002wjo.2_Silent_p.K186K|CDC25B_uc002wjp.2_Silent_p.K159K|CDC25B_uc002wjq.2_5'UTR|CDC25B_uc010gbc.2_5'Flank	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	200					cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						TTGTCTTCAAGATGCCATGGA	0.637													0	0	0	0.013537	0	13	24										A	3781635	G	A	3781635	2	1	55	1	0	0	0	0	0	0	0	1	3063	933	33	1		1	CDC25B	20	3781635	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		3781635	59243885	306	16200										
THBD	7056	broad.mit.edu	37	chr20	23029241	23029241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgagtaggagcccggctggtCggggttgggaacgcagaagt	19	8	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr20:23029241C>T	uc002wss.2	-	1	1061	c.901G>A	c.(901-903)GAC>AAC	p.D301N	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Missense_Mutation_p.D242N	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	301	EGF-like 2.|Extracellular (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	CCCGGCTGGTCGGGGTTGGGA	0.697													0	0	0	0.013537	0	13	17										T	23029241	C	T	23029241	3	4	55	1	0	0	0	0	1	0	0	0	15849	884	31	1	830	1	THBD	20	23029241	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	19247606	23029241	39996279	307	16201										
PHF20	51230	broad.mit.edu	37	chr20	34487428	34487428	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aaactgttgcactatcacatGaagtatttccatggaatgga	8	7	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr20:34487428G>A	uc002xek.1	+	10	1530	c.1419G>A	c.(1417-1419)ATG>ATA	p.M473I	PHF20_uc002xei.1_Missense_Mutation_p.M473I|PHF20_uc010gfo.1_Missense_Mutation_p.M473I|PHF20_uc002xej.1_Missense_Mutation_p.M357I	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	473	C2H2-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					ACTATCACATGAAGTATTTCC	0.478													0	0	0	0.013537	0	11	29										A	34487428	G	A	34487428	3	1	55	1	0	0	0	0	1	0	0	0	11831	1290	45	1	1453	1	PHF20	20	34487428	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	11458187	34487428	28538092	308	16202										
ZHX3	23051	broad.mit.edu	37	chr20	39832302	39832302	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aagtccccctcctgtaccctCtggctgccccacaacgtgac	7	19	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr20:39832302C>T	uc002xjs.1	-	3	1633	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Missense_Mutation_p.E419K|ZHX3_uc002xjt.1_Missense_Mutation_p.E419K|ZHX3_uc002xju.1_Missense_Mutation_p.E419K|ZHX3_uc002xjv.1_Missense_Mutation_p.E419K|ZHX3_uc002xjw.1_Missense_Mutation_p.E419K|ZHX3_uc010ggg.1_Missense_Mutation_p.E419K	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	419	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CCTGTACCCTCTGGCTGCCCC	0.582													0	0	0	0.007291	0	29	35										T	39832302	C	T	39832302	3	4	55	1	0	0	0	0	1	0	0	0	17674	922	32	1	1623	1	ZHX3	20	39832302	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5344874	39832302	23193218	309	16203										
CYP24A1	1591	broad.mit.edu	37	chr20	52774035	52774035	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggattaattttttccttctcCtgaagccaacgttcaggtct	7	10	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr20:52774035C>T	uc002xwv.2	-	10	1724	c.1326G>A	c.(1324-1326)CAG>CAA	p.Q442Q	CYP24A1_uc002xwu.1_Silent_p.Q300Q|CYP24A1_uc002xww.2_Intron	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	442					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TTTCCTTCTCCTGAAGCCAAC	0.428													0	0	0	0.006214	0	10	40										T	52774035	C	T	52774035	2	4	55	1	0	0	0	0	0	0	0	1	4154	680	24	2		2	CYP24A1	20	52774035	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	12941733	52774035	10251485	310	16204										
SYCP2	10388	broad.mit.edu	37	chr20	58450426	58450426	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tttagtagagatgagtttttCcattgttttgatagttcctt	8	4	0	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr20:58450426C>G	uc002yaz.2	-	33	3388	c.3249G>C	c.(3247-3249)TGG>TGC	p.W1083C		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1083					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ATGAGTTTTTCCATTGTTTTG	0.368													0	0	0	0.010729	0	12	15										G	58450426	C	G	58450426	3	3	55	1	0	0	0	0	1	0	0	0	15429	856	30	1	1391	1	SYCP2	20	58450426	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	5676391	58450426	4575094	311	16205										
DOPEY2	9980	broad.mit.edu	37	chr21	37603050	37603050	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcaggagaagaaagcaagtcCgaggagcctgcagggaagag	16	7	1	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr21:37603050C>T	uc002yvg.2	+	14	2047	c.1968C>T	c.(1966-1968)TCC>TCT	p.S656S	DOPEY2_uc011aeb.1_Silent_p.S656S	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	656					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						AAAGCAAGTCCGAGGAGCCTG	0.542													0	0	0	0.006999	0	41	46										T	37603050	C	T	37603050	2	4	55	1	0	0	0	0	0	0	0	1	4708	639	23	2		2	DOPEY2	21	37603050	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08		37603050	10526845	312	16206										
HMGN1	3150	broad.mit.edu	37	chr21	40720485	40720485	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	actcacctcttccttggcggCgccttcggcggagctgacct	11	16	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr21:40720485C>G	uc002yxo.2	-	2	238	c.34G>C	c.(34-36)GCC>CCC	p.A12P	HMGN1_uc002yxp.2_5'UTR|HMGN1_uc002yxq.2_5'UTR|HMGN1_uc002yxr.2_RNA	NM_004965	NP_004956	P05114	HMGN1_HUMAN	high-mobility group nucleosome binding domain 1	12					positive regulation of transcription elongation, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding			breast(1)	1		Prostate(19;8.69e-07)				TCCTTGGCGGCGCCTTCGGCG	0.677													0	0	0	0.001984	0	7	30										G	40720485	C	G	40720485	3	3	55	1	0	0	0	0	1	0	0	0	7234	768	27	4	288	4	HMGN1	21	40720485	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	3117435	40720485	7409410	313	16207										
U2AF1	7307	broad.mit.edu	37	chr21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tcggtttattgtgcaaccgaGagcacctgtctccatgacga	10	11	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358													0	0	0	0.004482	0	8	14										A	44524456	G	A	44524456	3	1	55	1	0	0	0	0	1	0	0	0	16818	942	33	1	720	1	U2AF1	21	44524456	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	3803971	44524456	3605439	314	16208										
TRAPPC10	7109	broad.mit.edu	37	chr21	45507706	45507706	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctctctttaccttcagcccCagcactcggaggggagagtg	11	13	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr21:45507706C>G	uc002zea.2	+	17	2835	c.2666C>G	c.(2665-2667)CCA>CGA	p.P889R	TRAPPC10_uc010gpo.2_Missense_Mutation_p.P600R|TRAPPC10_uc011afa.1_Missense_Mutation_p.P267R|TRAPPC10_uc011afb.1_5'Flank	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	889					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCTTCAGCCCCAGCACTCGGA	0.552													0	0	0	0.017118	0	37	58										G	45507706	C	G	45507706	3	3	55	1	0	0	0	0	1	0	0	0	16454	594	21	4	2732	4	TRAPPC10	21	45507706	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	983250	45507706	2622189	315	16209										
TRAPPC10	7109	broad.mit.edu	37	chr21	45518410	45518410	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tttttcgacaaagcttatgtAtgaaggtaggtggtctcgaa	11	5	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr21:45518410A>T	uc002zea.2	+	21	3510	c.3341A>T	c.(3340-3342)TAT>TTT	p.Y1114F	TRAPPC10_uc010gpo.2_Missense_Mutation_p.Y825F|TRAPPC10_uc011afa.1_Missense_Mutation_p.Y492F|TRAPPC10_uc011afb.1_Missense_Mutation_p.Y219F	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1114					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						AAGCTTATGTATGAAGGTAGG	0.249													0	0	0	0.005524	0	38	56										T	45518410	A	T	45518410	3	4	55	1	0	0	0	0	1	0	0	0	16454	449	16	5	3423	5	TRAPPC10	21	45518410	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	10704	45518410	2611485	316	16210										
UFD1L	7353	broad.mit.edu	37	chr22	19462610	19462610	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgagttggtccagggccgaGggtggcataattactgtgga	16	7	0	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr22:19462610G>A	uc002zpm.2	-	3	280	c.150C>T	c.(148-150)CCC>CCT	p.P50P	UFD1L_uc002zpo.2_Silent_p.P50P|UFD1L_uc011agy.1_Silent_p.P50P|UFD1L_uc002zpp.2_Silent_p.P3P|UFD1L_uc010grq.2_Silent_p.P3P|uc002zpq.1_5'Flank	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	50					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					CCAGGGCCGAGGGTGGCATAA	0.373													0	0	0	0.015359	0	31	55										A	19462610	G	A	19462610	2	1	55	1	0	0	0	0	0	0	0	1	16932	987	35	2		2	UFD1L	22	19462610	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08		19462610	31841956	317	16211										
ARVCF	421	broad.mit.edu	37	chr22	19965031	19965031	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gggcccgggctcggcctcctGgtacctgtcggccccgggca	16	17	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr22:19965031G>A	uc002zqz.2	-	9	2048	c.1777C>T	c.(1777-1779)CAG>TAG	p.Q593*	ARVCF_uc002zqy.2_Nonsense_Mutation_p.Q115*	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	593	ARM 6.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TCGGCCTCCTGGTACCTGTCG	0.662													0	0	0	0.01441	0	58	89										A	19965031	G	A	19965031	4	1	55	1	0	0	0	0	0	1	0	0	1003	1357	47	2	1155	2	ARVCF	22	19965031	Nonsense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	502421	19965031	31339535	318	16212										
JOSD1	9929	broad.mit.edu	37	chr22	39095872	39095872	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gtcctggaagacgttattgaGggcgtggagggcacaaagct	16	7	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr22:39095872G>T	uc003awf.2	-	1	588	c.121C>A	c.(121-123)CTC>ATC	p.L41I		NM_014876	NP_055691	Q15040	JOS1_HUMAN	Josephin domain containing 1	41	Josephin.						peptidase activity				0	Melanoma(58;0.04)					ACGTTATTGAGGGCGTGGAGG	0.537													1	0	0.000602214	0.014758	0.000654258	5	195										T	39095872	G	T	39095872	3	4	55	1	0	0	0	0	1	0	0	0	7958	1000	35	4	503	4	JOSD1	22	39095872	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	19130841	39095872	12208694	319	16213										
EP300	2033	broad.mit.edu	37	chr22	41565529	41565529	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gagtatacatatcttacctcGatagtgttcatttcttccgt	6	9	3	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr22:41565529G>T	uc003azl.3	+	26	4590	c.4195G>T	c.(4195-4197)GAT>TAT	p.D1399Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1399				D->Y: Does not interact with TFAP2A and inhibits transcriptional coactivation of TFAP2A by CITED2. Does not inhibit interaction with CITED2, DNA-binding of TFAP2A or nuclear localization of TFAP2A or CITED2.	apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.D1399Y(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ATCTTACCTCGATAGTGTTCA	0.338			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				1	0	1.08312e-15	0.009535	1.25085e-15	30	55										T	41565529	G	T	41565529	3	4	55	1	0	0	0	0	1	0	0	0	5148	1058	37	3	4297	3	EP300	22	41565529	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	2469657	41565529	9739037	320	16214										
L3MBTL2	83746	broad.mit.edu	37	chr22	41615486	41615486	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aggtggaggtgctcaacagtGatgctgtgctccccagccgg	15	11	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr22:41615486G>A	uc003azo.2	+	6	718	c.664G>A	c.(664-666)GAT>AAT	p.D222N	L3MBTL2_uc010gyi.1_Missense_Mutation_p.D131N|L3MBTL2_uc003azn.2_RNA|uc003azp.1_5'Flank	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	222	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						GCTCAACAGTGATGCTGTGCT	0.572													0	0	0	0.009718	0	39	53										A	41615486	G	A	41615486	3	1	55	1	0	0	0	0	1	0	0	0	8592	1290	45	1	686	1	L3MBTL2	22	41615486	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	49957	41615486	9689080	321	16215										
MEI1	150365	broad.mit.edu	37	chr22	42172208	42172208	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tccaagtgggcggtcttatcCgaggccacttcctgctgatc	11	13	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chr22:42172208C>G	uc003baz.1	+	21	2672	c.2647C>G	c.(2647-2649)CGA>GGA	p.R883G	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_RNA|MEI1_uc003bbb.1_Missense_Mutation_p.R269G|MEI1_uc003bbc.1_Missense_Mutation_p.R251G|MEI1_uc010gym.1_Missense_Mutation_p.R251G|MEI1_uc003bbd.1_Missense_Mutation_p.R126G|MEI1_uc010gyn.1_RNA|MEI1_uc003bbe.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	883							binding			central_nervous_system(1)|skin(1)	2						CGGTCTTATCCGAGGCCACTT	0.562													0	0	0	0.00874	0	41	63										G	42172208	C	G	42172208	3	3	55	1	0	0	0	0	1	0	0	0	9465	644	23	4	2729	4	MEI1	22	42172208	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	556722	42172208	9132358	322	16216										
SHROOM2	357	broad.mit.edu	37	chrX	9900215	9900215	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tgtacttgttcttcctctagAcaagcagatgcccagtgtcg	9	11	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:9900215A>G	uc004csu.1	+	6	2982	c.2892A>G	c.(2890-2892)AGA>AGG	p.R964R	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	964					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CTTCCTCTAGACAAGCAGATG	0.502													0	0	0	0.004656	0	27	16										G	9900215	A	G	9900215	2	3	55	1	0	0	0	0	0	0	0	1	14294	289	10	5		5	SHROOM2	23	9900215	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08		9900215	145370345	323	16217										
GPR64	10149	broad.mit.edu	37	chrX	19014182	19014182	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	tctttaccagaattttcagcCagccgtaactttccacaaca	4	13	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:19014182C>G	uc004cyx.2	-	27	2867	c.2703G>C	c.(2701-2703)CTG>CTC	p.L901L	GPR64_uc004cyy.2_Silent_p.L898L|GPR64_uc004cyz.2_Silent_p.L887L|GPR64_uc004czb.2_Silent_p.L901L|GPR64_uc004czc.2_Silent_p.L885L|GPR64_uc004czd.2_Silent_p.L877L|GPR64_uc004cze.2_Silent_p.L871L|GPR64_uc004czf.2_Silent_p.L863L|GPR64_uc004cza.2_Silent_p.L879L|GPR64_uc004cyw.2_Silent_p.L885L|GPR64_uc010nfj.2_Silent_p.L782L	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	901	Cytoplasmic (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					AATTTTCAGCCAGCCGTAACT	0.363													0	0	0	0.01441	0	50	16										G	19014182	C	G	19014182	2	3	55	1	0	0	0	0	0	0	0	1	6705	581	21	4		4	GPR64	23	19014182	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	9113967	19014182	136256378	324	16218										
MAP3K15	389840	broad.mit.edu	37	chrX	19389508	19389508	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aggtgaatctgactgatggaCgagctgtcaaagtccaggtc	13	8	2	3			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:19389508C>T	uc004czk.1	-	24	3311	c.1674G>A	c.(1672-1674)TCG>TCA	p.S558S	MAP3K15_uc004czj.1_Silent_p.S518S|MAP3K15_uc004czi.1_Silent_p.S17S	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	1083							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					GACTGATGGACGAGCTGTCAA	0.522													0	0	0	0.011902	0	43	13										T	19389508	C	T	19389508	2	4	55	1	0	0	0	0	0	0	0	1	9249	523	19	2		2	MAP3K15	23	19389508	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	375326	19389508	135881052	325	16219										
PRDX4	10549	broad.mit.edu	37	chrX	23700610	23700610	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atgagacactacgtttggttCaagcattccagtacactgac	8	10	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:23700610C>G	uc004dam.2	+	5	740	c.697C>G	c.(697-699)CAA>GAA	p.Q233E		NM_006406	NP_006397	Q13162	PRDX4_HUMAN	peroxiredoxin 4	233	Thioredoxin.				cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity			upper_aerodigestive_tract(1)	1						ACGTTTGGTTCAAGCATTCCA	0.378													0	0	0	0.01441	0	46	7										G	23700610	C	G	23700610	3	3	55	1	0	0	0	0	1	0	0	0	12467	827	29	1	715	1	PRDX4	23	23700610	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	4311102	23700610	131569950	326	16220										
KDM6A	7403	broad.mit.edu	37	chrX	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccagagtgcctagcgtctctCagcctggagtccgtcctgcc	11	16	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.004007	0	17	6										T	44922802	C	T	44922802	4	4	55	1	0	0	0	0	0	1	0	0	8137	827	29	1	1725	1	KDM6A	23	44922802	Nonsense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	21222192	44922802	110347758	327	16221										
SLC9A7	84679	broad.mit.edu	37	chrX	46529104	46529104	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgtgtagtaaaatttatctGagagctgtcccataatcttc	7	8	2	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:46529104G>A	uc004dgu.1	-	5	739	c.731C>T	c.(730-732)TCA>TTA	p.S244L	SLC9A7_uc004dgv.1_Missense_Mutation_p.S244L	NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	244					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						AAATTTATCTGAGAGCTGTCC	0.348													0	0	0	0.020292	0	15	5										A	46529104	G	A	46529104	3	1	55	1	0	0	0	0	1	0	0	0	14719	1294	45	1	1498	1	SLC9A7	23	46529104	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1606302	46529104	108741456	328	16222										
AR	367	broad.mit.edu	37	chrX	66765161	66765161	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	cgccagtttgctgctgctgcAgcagcagcagcagcagcagc	13	14	0	0	rs5902610		TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:66765161A>T	uc004dwu.1	+	1	1288	c.173A>T	c.(172-174)CAG>CTG	p.Q58L	AR_uc011mpd.1_Missense_Mutation_p.Q58L|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.Q58L	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	58	Modulating.|Poly-Gln.|Gln-rich.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CTGCTGCTgcagcagcagcag	0.328									Androgen_Insensitivity_Syndrome				0	0	0	0.00308	0	6	16										T	66765161	A	T	66765161	3	4	55	1	0	0	0	0	1	0	0	0	836	188	7	5	175	5	AR	23	66765161	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	20236057	66765161	88505399	329	16223										
SRPX2	27286	broad.mit.edu	37	chrX	99919817	99919817	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atcactagtggcacttacacCtgcacaaatggagtgcttct	8	11	2	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:99919817C>A	uc004egb.2	+	5	882	c.402C>A	c.(400-402)ACC>ACA	p.T134T		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	134	Sushi 2.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2						GCACTTACACCTGCACAAATG	0.512													1	0	0.004672	0.004672	0.00502611	3	13										A	99919817	C	A	99919817	2	1	55	1	0	0	0	0	0	0	0	1	15164	668	24	4		4	SRPX2	23	99919817	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	33154656	99919817	55350743	330	16224										
TCEAL2	140597	broad.mit.edu	37	chrX	101381895	101381895	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ccgcacgagggaaagccagaAgtagcttgtattctggaaga	13	8	1	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:101381895A>C	uc004eip.2	+	3	312	c.93A>C	c.(91-93)GAA>GAC	p.E31D		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	31					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GAAAGCCAGAAGTAGCTTGTA	0.418													0	0	0	0.009096	0	3	40										C	101381895	A	C	101381895	3	2	55	1	0	0	0	0	1	0	0	0	15668	69	3	5	95	5	TCEAL2	23	101381895	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	1462078	101381895	53888665	331	16225										
IL1RAPL2	26280	broad.mit.edu	37	chrX	105011334	105011334	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	aacaaggactttttggagaaCtccagcctataccctctatt	6	11	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:105011334C>A	uc004elz.1	+	11	2497	c.1741C>A	c.(1741-1743)CTC>ATC	p.L581I		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	581	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TTTTGGAGAACTCCAGCCTAT	0.453													1	0	5.18039e-06	0.00308	5.77056e-06	7	54										A	105011334	C	A	105011334	3	1	55	1	0	0	0	0	1	0	0	0	7662	565	20	4	1779	4	IL1RAPL2	23	105011334	Missense_Mutation	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	3629439	105011334	50259226	332	16226										
RNF113A	7737	broad.mit.edu	37	chrX	119005263	119005263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctggtcccacgggtttcgccGaacgggtggatttataaacc	12	11	0	0			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:119005263G>A	uc004esb.2	-	1	529	c.314C>T	c.(313-315)TCG>TTG	p.S105L	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	105							nucleic acid binding|zinc ion binding			breast(2)	2						GGGTTTCGCCGAACGGGTGGA	0.557													0	0	0	0.01441	0	194	31										A	119005263	G	A	119005263	3	1	55	1	0	0	0	0	1	0	0	0	13427	1059	37	1	721	1	RNF113A	23	119005263	Missense_Mutation	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	13993929	119005263	36265297	333	16227										
FAM122C	159091	broad.mit.edu	37	chrX	133979245	133979245	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	acctttacaggaagaagccaTggatttaataaatagagaaa	8	5	0	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:133979245T>C	uc004exz.1	+	4	662	c.257T>C	c.(256-258)ATG>ACG	p.M86T	FAM122C_uc011mvq.1_RNA|FAM122C_uc004exy.1_Missense_Mutation_p.M86T	NM_138819	NP_620174	Q6P4D5	F222C_HUMAN	hypothetical protein LOC159091	86											0	Acute lymphoblastic leukemia(192;0.000127)					GAAGAAGCCATGGATTTAATA	0.279													0	0	0	0.01441	0	109	27										C	133979245	T	C	133979245	3	2	55	1	0	0	0	0	1	0	0	0	5421	1464	51	5	735	5	FAM122C	23	133979245	Missense_Mutation	SNP	T	TCGA-DK-A2I6-01A-12D-A18F-08	14973982	133979245	21291315	334	16228										
GPR112	139378	broad.mit.edu	37	chrX	135431715	135431715	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ggaattcttcctaaccatggGctttctgagaacccttcatt	7	11	3	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:135431715G>C	uc004ezu.1	+	6	6141	c.5850G>C	c.(5848-5850)GGG>GGC	p.G1950G	GPR112_uc010nsb.1_Silent_p.G1745G|GPR112_uc010nsc.1_Silent_p.G1717G	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1950	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CTAACCATGGGCTTTCTGAGA	0.413													0	0	0	0.01441	0	82	18										C	135431715	G	C	135431715	2	2	55	1	0	0	0	0	0	0	0	1	6629	1190	42	4		4	GPR112	23	135431715	Silent	SNP	G	TCGA-DK-A2I6-01A-12D-A18F-08	1452470	135431715	19838845	335	16229										
FGF13	2258	broad.mit.edu	37	chrX	137717743	137717743	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	ctgactgctgctgacggtatAtcattgatgaatatgtcaca	9	8	2	4			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:137717743A>G	uc004fam.2	-	4	1138	c.476T>C	c.(475-477)ATA>ACA	p.I159T	FGF13_uc004fan.2_Missense_Mutation_p.I106T|FGF13_uc011mwi.1_Missense_Mutation_p.I140T|FGF13_uc004faq.2_Missense_Mutation_p.I169T|FGF13_uc004far.2_Missense_Mutation_p.I140T|FGF13_uc011mwj.1_Missense_Mutation_p.I169T|FGF13_uc011mwk.1_Missense_Mutation_p.I113T	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	159					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CTGACGGTATATCATTGATGA	0.398													0	0	0	0.01441	0	53	6										G	137717743	A	G	137717743	3	3	55	1	0	0	0	0	1	0	0	0	5842	449	16	5	269	5	FGF13	23	137717743	Missense_Mutation	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	2286028	137717743	17552817	336	16230										
FMR1	2332	broad.mit.edu	37	chrX	147014278	147014278	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	atacaagttccaaggaacttAgtaggtaagtcagaagtatc	9	6	1	1			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:147014278A>G	uc010nst.2	+	9	1065	c.876A>G	c.(874-876)TTA>TTG	p.L292L	FMR1_uc011mwz.1_Silent_p.L292L|FMR1_uc004fcj.2_Silent_p.L292L|FMR1_uc004fck.3_Silent_p.L292L|FMR1_uc004fcl.3_Silent_p.L153L|FMR1_uc011mxa.1_5'UTR	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	292	KH 2.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAAGGAACTTAGTAGGTAAGT	0.328									Fragile_X_syndrome				0	0	0	0.008361	0	31	11										G	147014278	A	G	147014278	2	3	55	1	0	0	0	0	0	0	0	1	5960	417	15	5		5	FMR1	23	147014278	Silent	SNP	A	TCGA-DK-A2I6-01A-12D-A18F-08	9296535	147014278	8256282	337	16231										
PLXNB3	5365	broad.mit.edu	37	chrX	153043511	153043511	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.264880952380952	89	5.15964971424442e-22	3.0102364454258	3.15492321589883	2.96288441145281	2.78843294222062e-10	4.53120353110851e-09	59	gctgtcatcgcccagaccttCattgactcctgtaccacctc	6	17	2	2			TCGA-DK-A2I6-01A-12D-A18F-08	TCGA-DK-A2I6-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	97a755af-ca00-4116-8a32-0984dbfb1585	985f656f-21ff-4dad-8ff3-4678322e5b31	g.chrX:153043511C>T	uc004fii.2	+	32	5544	c.5370C>T	c.(5368-5370)TTC>TTT	p.F1790F	PLXNB3_uc010nuk.2_Silent_p.F1813F|PLXNB3_uc011mzd.1_Silent_p.F1429F|SRPK3_uc004fik.2_5'UTR|SRPK3_uc010nul.2_5'Flank|SRPK3_uc004fin.2_5'Flank|SRPK3_uc004fil.2_5'Flank|SRPK3_uc004fim.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1790	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGACCTTCATTGACTCCT	0.572													0	0	0	0.009535	0	29	6										T	153043511	C	T	153043511	2	4	55	1	0	0	0	0	0	0	0	1	12125	825	29	1		1	PLXNB3	23	153043511	Silent	SNP	C	TCGA-DK-A2I6-01A-12D-A18F-08	6029233	153043511	2227049	338	16232										
SCNN1D	6339	broad.mit.edu	37	chr1	1221484	1221484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggtctgctcccgcgggaaccGcctcaagacgacgtcctggg	14	15	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:1221484G>A	uc001adu.1	+	6	869	c.245G>A	c.(244-246)CGC>CAC	p.R82H	SCNN1D_uc001adt.1_Missense_Mutation_p.R246H|SCNN1D_uc001adw.2_Missense_Mutation_p.R148H|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Missense_Mutation_p.R82H	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CGCGGGAACCGCCTCAAGACG	0.692													0	0	0	0.009096	0	4	25										A	1221484	G	A	1221484	3	1	56	1	0	0	0	0	1	0	0	0	13929	1087	38	2	457	2	SCNN1D	1	1221484	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		1221484	248029137	1	16233										
CHD5	26038	broad.mit.edu	37	chr1	6214906	6214906	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccgccacttggcacccaggaCggtcatcattttggacatgg	11	13	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:6214906C>T	uc001amb.1	-	5	659	c.559G>A	c.(559-561)GTC>ATC	p.V187I		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	187					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCACCCAGGACGGTCATCATT	0.498													0	0	0	0.01441	0	61	44										T	6214906	C	T	6214906	3	4	56	1	0	0	0	0	1	0	0	0	3328	536	19	2	5453	2	CHD5	1	6214906	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	4993422	6214906	243035715	2	16234										
PADI2	11240	broad.mit.edu	37	chr1	17395694	17395694	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaggccacgcacgtgcatctCcaggcagcattcctcctcaa	9	16	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:17395694C>T	uc001baf.2	-	16	1925	c.1843G>A	c.(1843-1845)GAG>AAG	p.E615K	PADI2_uc010ocm.1_Missense_Mutation_p.E499K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	615					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ACGTGCATCTCCAGGCAGCAT	0.592													0	0	0	0.010729	0	7	98										T	17395694	C	T	17395694	3	4	56	1	0	0	0	0	1	0	0	0	11378	864	30	1	158	1	PADI2	1	17395694	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	11180788	17395694	231854927	3	16235										
PADI4	23569	broad.mit.edu	37	chr1	17682587	17682587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtccgtgggccacgtggacGagttcctgagctttgtgcca	14	11	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:17682587G>A	uc001baj.2	+	12	1448	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	474					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCACGTGGACGAGTTCCTGAG	0.632													0	0	0	0.004482	0	8	48										A	17682587	G	A	17682587	3	1	56	1	0	0	0	0	1	0	0	0	11380	1059	37	1	1466	1	PADI4	1	17682587	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	286893	17682587	231568034	4	16236										
USP48	84196	broad.mit.edu	37	chr1	22074693	22074693	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggaaggctaagaagtcgaatCtttcttgttgcattctgttt	10	6	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:22074693C>G	uc001bfb.2	-	7	1084	c.846G>C	c.(844-846)AAG>AAC	p.K282N	USP48_uc010odq.1_Missense_Mutation_p.K282N|USP48_uc009vqc.2_Missense_Mutation_p.K282N|USP48_uc001bfc.2_Missense_Mutation_p.K282N|USP48_uc001bfe.1_Missense_Mutation_p.K282N|USP48_uc001bff.2_Missense_Mutation_p.K282N	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	282					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GAAGTCGAATCTTTCTTGTTG	0.348													0	0	0	0.009096	0	4	25										G	22074693	C	G	22074693	3	3	56	1	0	0	0	0	1	0	0	0	17076	912	32	1	2353	1	USP48	1	22074693	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	4392106	22074693	227175928	5	16237										
ZNF436	80818	broad.mit.edu	37	chr1	23688971	23688971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acacttgtagggcctctcccCtgtgtggactcgatagtgtt	11	11	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:23688971C>G	uc001bgt.2	-	3	1285	c.904G>C	c.(904-906)GGG>CGG	p.G302R	ZNF436_uc001bgu.2_Missense_Mutation_p.G302R	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		GGCCTCTCCCCTGTGTGGACT	0.522													0	0	0	0.021523	0	22	108										G	23688971	C	G	23688971	3	3	56	1	0	0	0	0	1	0	0	0	17906	681	24	4	512	4	ZNF436	1	23688971	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1614278	23688971	225561650	6	16238										
ASAP3	55616	broad.mit.edu	37	chr1	23763473	23763473	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaaaagcgcacgcccagttcGcggtggacgcccgagcactg	14	14	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:23763473G>C	uc001bha.2	-	15	1531	c.1407C>G	c.(1405-1407)CGC>CGG	p.R469R	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Silent_p.R338R|ASAP3_uc010oea.1_Silent_p.R460R|ASAP3_uc001bhb.2_5'UTR	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	469	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CGCCCAGTTCGCGGTGGACGC	0.677													0	0	0	0.00308	0	6	29										C	23763473	G	C	23763473	2	2	56	1	0	0	0	0	0	0	0	1	1012	1074	38	4		4	ASAP3	1	23763473	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	74502	23763473	225487148	7	16239										
ARID1A	8289	broad.mit.edu	37	chr1	27107008	27107008	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aggacagccttgccgccacaCagttccagcagagccaggcc	11	16	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:27107008C>T	uc001bmv.1	+	20	6992	c.6619C>T	c.(6619-6621)CAG>TAG	p.Q2207*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1990*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q1053*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.Q535*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.Q449*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2207					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGCCGCCACACAGTTCCAGCA	0.642			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	59	65										T	27107008	C	T	27107008	4	4	56	1	0	0	0	0	0	1	0	0	913	479	17	2	6697	2	ARID1A	1	27107008	Nonsense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3343535	27107008	222143613	8	16240										
TTC39A	22996	broad.mit.edu	37	chr1	51761767	51761767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccaccgaaataattccacttCgtcgtccccgaacggcttgt	7	15	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:51761767C>T	uc001csl.2	-	13	1342	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	TTC39A_uc001csk.2_Missense_Mutation_p.E378K|TTC39A_uc010ond.1_Missense_Mutation_p.E350K|TTC39A_uc010one.1_Missense_Mutation_p.E377K|TTC39A_uc010onf.1_Missense_Mutation_p.E381K|TTC39A_uc001csn.2_Missense_Mutation_p.E412K|TTC39A_uc001csj.2_Missense_Mutation_p.E14K	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	413							binding			skin(1)	1						AATTCCACTTCGTCGTCCCCG	0.592													0	0	0	0.016723	0	10	4										T	51761767	C	T	51761767	3	4	56	1	0	0	0	0	1	0	0	0	16704	893	31	1	628	1	TTC39A	1	51761767	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	24654759	51761767	197488854	9	16241										
CC2D1B	200014	broad.mit.edu	37	chr1	52821911	52821911	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgggtgggagggtcgaggccCtgagcctgggccagctgcag	20	10	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:52821911C>A	uc001ctq.1	-	18	2157	c.2019G>T	c.(2017-2019)CAG>CAT	p.Q673H	CC2D1B_uc001ctr.2_Missense_Mutation_p.Q213H|CC2D1B_uc001cts.2_Missense_Mutation_p.Q358H	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	673										ovary(2)	2						GGTCGAGGCCCTGAGCCTGGG	0.572													1	0	8.10497e-08	0.010504	9.039e-08	18	71										A	52821911	C	A	52821911	3	1	56	1	0	0	0	0	1	0	0	0	2727	680	24	4	585	4	CC2D1B	1	52821911	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1060144	52821911	196428710	10	16242										
LRRC7	57554	broad.mit.edu	37	chr1	70509735	70509735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agcatgactttaaacttgcaGactaagtctaaatttgatca	6	7	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:70509735G>C	uc001dep.2	+	20	3984	c.3954G>C	c.(3952-3954)CAG>CAC	p.Q1318H	LRRC7_uc009wbg.2_Missense_Mutation_p.Q602H|LRRC7_uc001deq.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1318						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TAAACTTGCAGACTAAGTCTA	0.398													0	0	0	0.010729	0	12	45										C	70509735	G	C	70509735	3	2	56	1	0	0	0	0	1	0	0	0	9020	933	33	1	4032	1	LRRC7	1	70509735	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	17687824	70509735	178740886	11	16243										
DDX20	11218	broad.mit.edu	37	chr1	112309338	112309338	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtcatagggaaatacgtctGagtttttctgatacctatca	8	7	4	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:112309338G>A	uc001ebs.2	+	11	2649	c.2292G>A	c.(2290-2292)CTG>CTA	p.L764L	DDX20_uc010owf.1_Silent_p.L526L|DDX20_uc001ebt.2_Silent_p.L372L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	764					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATACGTCTGAGTTTTTCTG	0.453													0	0	0	0.004482	0	9	86										A	112309338	G	A	112309338	2	1	56	1	0	0	0	0	0	0	0	1	4348	1277	45	1		1	DDX20	1	112309338	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	41799603	112309338	136941283	12	16244										
SYT6	148281	broad.mit.edu	37	chr1	114680320	114680320	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctcatcaaaggtggggttcaGggtcttgcggtgcacccggg	16	10	4	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:114680320G>A	uc001eev.2	-	3	863	c.613C>T	c.(613-615)CTG>TTG	p.L205L		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	290	Cytoplasmic (Potential).|C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGGGTTCAGGGTCTTGCGG	0.557													0	0	0	0.004007	0	14	71										A	114680320	G	A	114680320	2	1	56	1	0	0	0	0	0	0	0	1	15475	991	35	2		2	SYT6	1	114680320	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2370982	114680320	134570301	13	16245										
HIST2H2BE	8349	broad.mit.edu	37	chr1	149857978	149857978	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcctctcccgcgatgcgctcGaagatgtcgttgacgaagga	13	12	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:149857978G>C	uc001etc.2	-	1	255	c.213C>G	c.(211-213)TTC>TTG	p.F71L	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CGATGCGCTCGAAGATGTCGT	0.622													0	0	0	0.01441	0	152	138										C	149857978	G	C	149857978	3	2	56	1	0	0	0	0	1	0	0	0	7179	1049	37	1	171	1	HIST2H2BE	1	149857978	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	35177658	149857978	99392643	14	16246										
DENND4B	9909	broad.mit.edu	37	chr1	153907309	153907309	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgctgctgctgctgctgttgCtgctgctgctgctgttgccg	14	12	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:153907309C>T	uc001fdd.1	-	18	3101	c.2700G>A	c.(2698-2700)CAG>CAA	p.Q900Q	uc001fdc.1_RNA	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.468													0	0	0	0.004482	0	7	120										T	153907309	C	T	153907309	2	4	56	1	0	0	0	0	0	0	0	1	4434	796	28	2		2	DENND4B	1	153907309	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	4049331	153907309	95343312	15	16247										
NES	10763	broad.mit.edu	37	chr1	156640211	156640211	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctgctcgctctctactttccCcagggcttcagccctcccct	6	20	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:156640211C>G	uc001fpq.2	-	4	3902	c.3769G>C	c.(3769-3771)GGG>CGG	p.G1257R		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1257	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCTACTTTCCCCAGGGCTTCA	0.642													0	0	0	0.013726	0	27	240										G	156640211	C	G	156640211	3	3	56	1	0	0	0	0	1	0	0	0	10337	623	22	4	1100	4	NES	1	156640211	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2732902	156640211	92610410	16	16248										
FCRL5	83416	broad.mit.edu	37	chr1	157489551	157489551	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acctggcggggtcagaggcaGgctttctccctgtaaaggaa	14	10	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:157489551G>C	uc001fqu.2	-	13	2800	c.2642C>G	c.(2641-2643)CCT>CGT	p.P881R	FCRL5_uc009wsm.2_Missense_Mutation_p.P881R	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	881	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GTCAGAGGCAGGCTTTCTCCC	0.502													0	0	0	0.013537	0	8	60										C	157489551	G	C	157489551	3	2	56	1	0	0	0	0	1	0	0	0	5798	1000	35	4	311	4	FCRL5	1	157489551	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	849340	157489551	91761070	17	16249										
DCAF6	55827	broad.mit.edu	37	chr1	167973115	167973115	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tatattgtaataggagagcaGagtcccaatgtgtcattgat	10	5	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:167973115G>C	uc001gew.2	+	9	1247	c.1005G>C	c.(1003-1005)CAG>CAC	p.Q335H	DCAF6_uc001gev.2_Missense_Mutation_p.Q335H|DCAF6_uc001gex.2_Missense_Mutation_p.Q335H|DCAF6_uc010plk.1_Missense_Mutation_p.Q304H|DCAF6_uc001gey.2_Missense_Mutation_p.Q188H	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	335					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TAGGAGAGCAGAGTCCCAATG	0.353													0	0	0	0.009096	0	3	111										C	167973115	G	C	167973115	3	2	56	1	0	0	0	0	1	0	0	0	4274	933	33	1	1039	1	DCAF6	1	167973115	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	10483564	167973115	81277506	18	16250										
TIPRL	261726	broad.mit.edu	37	chr1	168169157	168169157	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctagcatgttccaccttcccTcttcacggaacctaatgaaa	5	14	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:168169157T>C	uc001gfg.2	+	7	837	c.692T>C	c.(691-693)CTC>CCC	p.L231P	TIPRL_uc001gfh.2_Silent_p.P232P	NM_152902	NP_690866	O75663	TIPRL_HUMAN	TIP41, TOR signalling pathway regulator-like	231	Interaction with PPP2CA.				DNA damage checkpoint|negative regulation of protein phosphatase type 2A activity	cytoplasm	protein binding			ovary(1)	1	all_hematologic(923;0.215)					CCACCTTCCCTCTTCACGGAA	0.343													0	0	0	0.01441	0	123	34										C	168169157	T	C	168169157	3	2	56	1	0	0	0	0	1	0	0	0	15923	1551	54	5	743	5	TIPRL	1	168169157	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	196042	168169157	81081464	19	16251										
CACNA1E	777	broad.mit.edu	37	chr1	181680116	181680116	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgccaaagagagagagagagTggagaaccgaagggctttca	15	6	1	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:181680116T>A	uc001gow.2	+	8	1247	c.1082T>A	c.(1081-1083)GTG>GAG	p.V361E	CACNA1E_uc009wxs.2_Missense_Mutation_p.V268E	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	361	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGAGAGAGAGTGGAGAACCGA	0.522													0	0	0	0.00308	0	6	195										A	181680116	T	A	181680116	3	1	56	1	0	0	0	0	1	0	0	0	2542	1696	59	5	1112	5	CACNA1E	1	181680116	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	13510959	181680116	67570505	20	16252										
FAM129A	116496	broad.mit.edu	37	chr1	184777366	184777366	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagattcataagccggtctaGatgctgcattttggtgaagg	12	6	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:184777366G>C	uc001gra.2	-	10	1371	c.1177C>G	c.(1177-1179)CTA>GTA	p.L393V	FAM129A_uc001grb.1_Missense_Mutation_p.L156V|FAM129A_uc009wyh.1_Missense_Mutation_p.L221V|FAM129A_uc009wyi.1_Missense_Mutation_p.L191V	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	393					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						AGCCGGTCTAGATGCTGCATT	0.433													0	0	0	0.01441	0	42	18										C	184777366	G	C	184777366	3	2	56	1	0	0	0	0	1	0	0	0	5436	933	33	1	1629	1	FAM129A	1	184777366	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	3097250	184777366	64473255	21	16253										
CTSE	1510	broad.mit.edu	37	chr1	206318358	206318358	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	caagaagaagctgcgggcacGgagccagctctctgagttct	13	11	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:206318358G>A	uc001hdu.2	+	2	234	c.116G>A	c.(115-117)CGG>CAG	p.R39Q	CTSE_uc001hdv.2_Missense_Mutation_p.R39Q|CTSE_uc010prs.1_Intron	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	39					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			CTGCGGGCACGGAGCCAGCTC	0.557													0	0	0	0.020292	0	13	40										A	206318358	G	A	206318358	3	1	56	1	0	0	0	0	1	0	0	0	4033	1116	39	2	122	2	CTSE	1	206318358	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	21540992	206318358	42932263	22	16254										
ACTN2	88	broad.mit.edu	37	chr1	236907968	236907968	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaaggattacgagtcggcgtCgctgacagaggtgcgggctc	17	9	0	2	rs143749154	byFrequency	TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr1:236907968C>T	uc001hyf.2	+	12	1502	c.1298C>T	c.(1297-1299)TCG>TTG	p.S433L	ACTN2_uc001hyg.2_Missense_Mutation_p.S225L|ACTN2_uc009xgi.1_Missense_Mutation_p.S433L|ACTN2_uc010pxu.1_Missense_Mutation_p.S122L|ACTN2_uc001hyh.2_Missense_Mutation_p.S121L	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	433	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGTCGGCGTCGCTGACAGAG	0.602													0	0	0	0.00874	0	38	22										T	236907968	C	T	236907968	3	4	56	1	0	0	0	0	1	0	0	0	205	893	31	1	1344	1	ACTN2	1	236907968	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	30589610	236907968	12342653	23	16255										
SH3YL1	26751	broad.mit.edu	37	chr2	234213	234213	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cctccgagggtcagatttccGccttttgcaaaagcttctac	8	13	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234213G>C	uc002qvx.2	-	5	435	c.351C>G	c.(349-351)GGC>GGG	p.G117G	SH3YL1_uc002qvy.2_Silent_p.G117G|SH3YL1_uc002qvz.2_RNA|SH3YL1_uc002qwa.2_RNA|SH3YL1_uc010ewe.2_Silent_p.G21G|SH3YL1_uc002qvu.2_RNA|SH3YL1_uc002qvv.2_Silent_p.G21G|SH3YL1_uc002qvw.2_RNA	NM_015677	NP_056492	Q96HL8	SH3Y1_HUMAN	SH3 domain containing, Ysc84-like 1 isoform 1	117										ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		TCAGATTTCCGCCTTTTGCAA	0.418													0	0	0	0.007413	0	15	118										C	234213	G	C	234213	2	2	56	1	0	0	0	0	0	0	0	1	14263	1074	38	4		4	SH3YL1	2	234213	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		234213	242965160	24	16256										
KLF11	8462	broad.mit.edu	37	chr2	10186443	10186443	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aggtgacctgttgcggataaGacccctcacgcctgtctctg	11	13	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:10186443G>T	uc002raf.1	+	2	371	c.209G>T	c.(208-210)AGA>ATA	p.R70I	KLF11_uc010yjc.1_Missense_Mutation_p.R53I	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	70					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		TTGCGGATAAGACCCCTCACG	0.512													1	0	7.03913e-09	0.013537	7.96882e-09	10	45										T	10186443	G	T	10186443	3	4	56	1	0	0	0	0	1	0	0	0	8339	942	33	3	215	3	KLF11	2	10186443	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9952230	10186443	233012930	25	16257										
FAM49A	81553	broad.mit.edu	37	chr2	16747025	16747025	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atttctctctctccttctgtAggctgagcatctaagaaaca	6	11	4	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:16747025A>G	uc010exm.1	-	3	229	c.81T>C	c.(79-81)CCT>CCC	p.P27P	FAM49A_uc002rck.1_Silent_p.P27P	NM_030797	NP_110424	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	27						intracellular					0	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CTCCTTCTGTAGGCTGAGCAT	0.498													0	0	0	0.004672	0	3	29										G	16747025	A	G	16747025	2	3	56	1	0	0	0	0	0	0	0	1	5575	407	15	5		5	FAM49A	2	16747025	Silent	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	6560582	16747025	226452348	26	16258										
C2orf16	84226	broad.mit.edu	37	chr2	27800283	27800283	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagctatggggttgaccgctGaggcaaggatacaagcaaat	13	7	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:27800283G>A	uc002rkz.3	+	1	895	c.844G>A	c.(844-846)GAG>AAG	p.E282K		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	282										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTTGACCGCTGAGGCAAGGAT	0.463													0	0	0	0.021523	0	26	54										A	27800283	G	A	27800283	3	1	56	1	0	0	0	0	1	0	0	0	2157	1291	45	1	846	1	C2orf16	2	27800283	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	11053258	27800283	215399090	27	16259										
VIT	5212	broad.mit.edu	37	chr2	37035743	37035743	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcctgcagcaagacctgcttGaactcggctgacattggctt	11	12	0	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:37035743G>C	uc002rpl.2	+	15	1739	c.1518G>C	c.(1516-1518)TTG>TTC	p.L506F	VIT_uc002rpm.2_Missense_Mutation_p.L484F|VIT_uc010ezv.2_Missense_Mutation_p.L462F|VIT_uc010ezw.2_Missense_Mutation_p.L463F	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	491						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				AGACCTGCTTGAACTCGGCTG	0.612													0	0	0	0.021523	0	20	136										C	37035743	G	C	37035743	3	2	56	1	0	0	0	0	1	0	0	0	17168	1281	45	1	1697	1	VIT	2	37035743	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9235460	37035743	206163630	28	16260										
SPTBN1	6711	broad.mit.edu	37	chr2	54883083	54883084	+	Missense_Mutation	DNP	GA	GA	TT													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttactgcagttgacggaaaaGaggaaagaaatgatcgacaa							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:54883083_54883084GA>TT	uc002rxu.2	+	29	6243_6244	c.5994_5995GA>TT	c.(5992-5997)AAGAGG>AATTGG	p.1998_1999KR>NW	SPTBN1_uc002rxx.2_Missense_Mutation_p.1985_1986KR>NW|SPTBN1_uc002rxy.2_Missense_Mutation_p.143_144KR>NW|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1998_1999	Spectrin 17.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			TGACGGAAAAGAGGAAAGAAAT	0.411													0	0	0	0.004672	0	5	38										TT	54883084	GA	TT	54883083	3	4	56	1	0	0	0	0	1	0	0	0	15118	933	33	3	6217	3	SPTBN1	2	54883083	Missense_Mutation	DNP	GA	TCGA-DK-A3IK-01A-32D-A21A-08	17847340	54883083	188316290	29	16261										
ZAP70	7535	broad.mit.edu	37	chr2	98340715	98340715	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aacggcacctacgccattgcCggcggcaaagcgcactgtgg	13	14	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:98340715C>T	uc002syd.1	+	3	423	c.216C>T	c.(214-216)GCC>GCT	p.A72A	ZAP70_uc010yvf.1_Silent_p.A72A|ZAP70_uc002sye.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	72	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						ACGCCATTGCCGGCGGCAAAG	0.677													0	0	0	0.004672	0	3	34										T	98340715	C	T	98340715	2	4	56	1	0	0	0	0	0	0	0	1	17511	639	23	2		2	ZAP70	2	98340715	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	43457632	98340715	144858658	30	16262										
EIF5B	9669	broad.mit.edu	37	chr2	99993068	99993068	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgatcggactaaagaagaaaGggcttatgacaaagcaaaac	10	6	0	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:99993068G>C	uc002tab.2	+	10	1995	c.1811G>C	c.(1810-1812)AGG>ACG	p.R604T		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	604					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AAAGAAGAAAGGGCTTATGAC	0.373													0	0	0	0.016723	0	10	41										C	99993068	G	C	99993068	3	2	56	1	0	0	0	0	1	0	0	0	5044	1000	35	4	1849	4	EIF5B	2	99993068	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1652353	99993068	143206305	31	16263										
MERTK	10461	broad.mit.edu	37	chr2	112779916	112779916	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tccagaaccatgagatgtatGactatcttctccatggccac	7	12	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:112779916G>A	uc002thk.1	+	18	2553	c.2431G>A	c.(2431-2433)GAC>AAC	p.D811N	MERTK_uc002thl.1_Missense_Mutation_p.D635N	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	811	Protein kinase.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TGAGATGTATGACTATCTTCT	0.537													0	0	0	0.00499	0	17	47										A	112779916	G	A	112779916	3	1	56	1	0	0	0	0	1	0	0	0	9479	1290	45	1	2501	1	MERTK	2	112779916	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	12786848	112779916	130419457	32	16264										
CBWD2	150472	broad.mit.edu	37	chr2	114195539	114195539	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tggagacgacgcaaagcgagGaggaggaaaagtctggcctc	16	8	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:114195539G>C	uc002tju.2	+	1	272	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	CBWD2_uc002tjt.2_Missense_Mutation_p.E32Q|CBWD2_uc010yxw.1_5'UTR|CBWD2_uc002tjv.2_5'UTR|CBWD2_uc010fkv.2_RNA	NM_172003	NP_742000	Q8IUF1	CBWD2_HUMAN	COBW domain-containing protein 2	32	Poly-Glu.						ATP binding|protein binding				0						GCAAAGCGAGGAGGAGGAAAA	0.547													0	0	0	0.001168	0	5	205										C	114195539	G	C	114195539	3	2	56	1	0	0	0	0	1	0	0	0	2713	1175	41	1	96	1	CBWD2	2	114195539	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1415623	114195539	129003834	33	16265										
SP110	3431	broad.mit.edu	37	chr2	231081529	231081529	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttagtgatgatggagttgtcTaggaggccttcaaagaaggg	15	4	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:231081529T>C	uc002vqh.3	-	2	354	c.114A>G	c.(112-114)CTA>CTG	p.L38L	SP110_uc002vqg.3_Silent_p.L38L|SP110_uc002vqi.3_Silent_p.L38L|SP110_uc010fxk.2_Silent_p.L38L	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	38	HSR.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TGGAGTTGTCTAGGAGGCCTT	0.483													0	0	0	0.010504	0	18	70										C	231081529	T	C	231081529	2	2	56	1	0	0	0	0	0	0	0	1	14961	1509	53	5		5	SP110	2	231081529	Silent	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	116885990	231081529	12117844	34	16266										
UGT1A9	54600	broad.mit.edu	37	chr2	234581244	234581244	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aggaacatttattatgccacCgttttttcaaaaatgcccta	5	9	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234581244C>T	uc002vus.2	+	1	701	c.664C>T	c.(664-666)CGT>TGT	p.R222C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.R222C	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	222					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	ATTATGCCACCGTTTTTTCAA	0.428													0	0	0	0.01441	0	52	132										T	234581244	C	T	234581244	3	4	56	1	0	0	0	0	1	0	0	0	16949	652	23	2	666	2	UGT1A9	2	234581244	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3499715	234581244	8618129	35	16267										
UGT1A6	54578	broad.mit.edu	37	chr2	234602440	234602440	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atgactttgtgcttgaatatCctaggccggtcatgcccaac	9	11	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234602440C>T	uc002vuv.3	+	1	929	c.790C>T	c.(790-792)CCT>TCT	p.P264S	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Missense_Mutation_p.P264S	NM_001072	NP_001063	P19224	UD16_HUMAN	UDP glycosyltransferase 1 family, polypeptide A6	264					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity				0		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		GCTTGAATATCCTAGGCCGGT	0.433													0	0	0	0.01441	0	87	256										T	234602440	C	T	234602440	3	4	56	1	0	0	0	0	1	0	0	0	16946	855	30	1	792	1	UGT1A6	2	234602440	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	21196	234602440	8596933	36	16268										
HJURP	55355	broad.mit.edu	37	chr2	234761219	234761219	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gacactaaatacctggatctCtccttcgtttctttccttta	4	12	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr2:234761219C>T	uc002vvg.2	-	3	298	c.232G>A	c.(232-234)GAG>AAG	p.E78K	HJURP_uc010znd.1_Missense_Mutation_p.E71K|HJURP_uc010zne.1_Missense_Mutation_p.E71K	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	78					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACCTGGATCTCTCCTTCGTTT	0.378													0	0	0	0.014758	0	5	15										T	234761219	C	T	234761219	3	4	56	1	0	0	0	0	1	0	0	0	7189	922	32	1	2042	1	HJURP	2	234761219	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	158779	234761219	8438154	37	16269										
IL17RE	132014	broad.mit.edu	37	chr3	9956436	9956436	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctactgggtgttgttctggcCctcacctgccggcgcccaca	11	16	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:9956436C>G	uc003btu.2	+	16	1539	c.1422C>G	c.(1420-1422)GCC>GCG	p.A474A	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_5'Flank|IL17RC_uc011ato.1_5'Flank|IL17RC_uc010hcs.2_5'Flank|IL17RC_uc003btz.2_5'Flank|IL17RC_uc011atp.1_5'Flank|IL17RC_uc003bud.2_5'Flank|IL17RC_uc003bua.2_5'Flank|IL17RC_uc003bub.2_5'Flank|IL17RC_uc010hct.2_5'Flank|IL17RC_uc010hcu.2_5'Flank|IL17RC_uc010hcv.2_5'Flank|IL17RC_uc011atq.1_5'Flank|IL17RC_uc003buc.2_5'Flank|IL17RE_uc003btw.2_Silent_p.A474A|IL17RE_uc003btx.2_Silent_p.A358A|IL17RE_uc010hcq.2_Missense_Mutation_p.P499A|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	474	Helical; (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		TTGTTCTGGCCCTCACCTGCC	0.627													0	0	0	0.009096	0	3	85										G	9956436	C	G	9956436	2	3	56	1	0	0	0	0	0	0	0	1	7643	610	22	4		4	IL17RE	3	9956436	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		9956436	188065994	38	16270										
RFTN1	23180	broad.mit.edu	37	chr3	16450896	16450896	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gctcaccttcttaatgaactCtgggatgagtttctggtctg	10	9	5	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:16450896C>G	uc003cay.2	-	4	709	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	RFTN1_uc010hes.2_Missense_Mutation_p.E107Q	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	143						plasma membrane				ovary(3)|central_nervous_system(1)	4						TTAATGAACTCTGGGATGAGT	0.473													0	0	0	0.016723	0	10	57										G	16450896	C	G	16450896	3	3	56	1	0	0	0	0	1	0	0	0	13258	922	32	1	1337	1	RFTN1	3	16450896	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	6494460	16450896	181571534	39	16271										
ZNF385D	79750	broad.mit.edu	37	chr3	21552474	21552474	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcttccagtgctttgagcttCttggcatgtttcgtgccttt	10	10	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:21552474C>G	uc003cce.2	-	4	726	c.318G>C	c.(316-318)AAG>AAC	p.K106N	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	106	Matrin-type 1.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTTTGAGCTTCTTGGCATGTT	0.458													0	0	0	0.013537	0	10	37										G	21552474	C	G	21552474	3	3	56	1	0	0	0	0	1	0	0	0	17875	912	32	1	889	1	ZNF385D	3	21552474	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	5101578	21552474	176469956	40	16272										
XIRP1	165904	broad.mit.edu	37	chr3	39225689	39225689	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tggccccgtctgtagctccaGaacactcttttgccaccctc	7	17	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:39225689G>A	uc003cjk.1	-	2	5469	c.5248C>T	c.(5248-5250)CTG>TTG	p.L1750L	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Silent_p.L433L	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1750	Interaction with FLNC.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGTAGCTCCAGAACACTCTTT	0.562													0	0	0	0.006999	0	35	166										A	39225689	G	A	39225689	2	1	56	1	0	0	0	0	0	0	0	1	17426	933	33	1		1	XIRP1	3	39225689	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	17673215	39225689	158796741	41	16273										
HHATL	57467	broad.mit.edu	37	chr3	42740315	42740317	+	In_Frame_Del	DEL	AGC	AGC	-													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agaggcccacacagtgaccaAgcagcagcagcaggtaccaa							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:42740315_42740317delAGC	uc003clw.2	-	6	513_515	c.366_368delGCT	c.(364-369)CTGCTT>CTT	p.122_123LL>L	HHATL_uc003clx.2_In_Frame_Del_p.122_123LL>L	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	122_123					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		ACAGTGACCAAGCAGCAGCAGCA	0.621																		7	139	---	---								-	42740317	AGC	-	42740315	7	5	56	1	0	1	0	1	0	0	0	0	7090	72	3	0	1178	0	HHATL	3	42740315	In_Frame_Del	DEL	AGC	TCGA-DK-A3IK-01A-32D-A21A-08	3514626	42740315	155282115	42	16274										
SLC6A20	54716	broad.mit.edu	37	chr3	45800488	45800488	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tctcaggccacggggtctgcGtctcccctcttgaggcgacg	13	15	4	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:45800488G>A	uc011bai.1	-	11	1885	c.1761C>T	c.(1759-1761)GAC>GAT	p.D587D	SLC6A20_uc003cow.2_Silent_p.D237D|SLC6A20_uc011baj.1_Silent_p.D550D	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	587	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CGGGGTCTGCGTCTCCCCTCT	0.577													0	0	0	0.009096	0	4	53										A	45800488	G	A	45800488	2	1	56	1	0	0	0	0	0	0	0	1	14684	1136	40	2		2	SLC6A20	3	45800488	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	3060173	45800488	152221942	43	16275										
ARL13B	200894	broad.mit.edu	37	chr3	93714777	93714777	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	taaaaccgcaacagcaaaggGaatccaaggaggtaagctga	11	8	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:93714777G>T	uc003drc.2	+	2	405	c.119G>T	c.(118-120)GGA>GTA	p.G40V	ARL13B_uc010hop.2_Nonsense_Mutation_p.E10*|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_5'UTR|ARL13B_uc003drf.2_Missense_Mutation_p.G40V|ARL13B_uc003drg.2_Intron	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	40							GTP binding				0						ACAGCAAAGGGAATCCAAGGA	0.289													1	0	0.000978159	0.010729	0.00103692	8	39										T	93714777	G	T	93714777	3	4	56	1	0	0	0	0	1	0	0	0	929	1174	41	3	125	3	ARL13B	3	93714777	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	47914289	93714777	104307653	44	16276										
PLCH1	23007	broad.mit.edu	37	chr3	155215191	155215191	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cggcagagcttcatggttttCcttcggcgacccaatctgtg	11	12	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:155215191C>T	uc011bok.1	-	14	2053	c.1776G>A	c.(1774-1776)AGG>AGA	p.R592R	PLCH1_uc011boj.1_Silent_p.R592R|PLCH1_uc011bol.1_Silent_p.R574R	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	592					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCATGGTTTTCCTTCGGCGAC	0.463													0	0	0	0.006122	0	15	82										T	155215191	C	T	155215191	2	4	56	1	0	0	0	0	0	0	0	1	12037	854	30	1		1	PLCH1	3	155215191	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	61500414	155215191	42807239	45	16277										
MFN1	55669	broad.mit.edu	37	chr3	179109794	179109794	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagctgttcaacttgaaaatGagctggagaattttactaag	9	5	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:179109794G>C	uc003fjs.2	+	18	2299	c.2173G>C	c.(2173-2175)GAG>CAG	p.E725Q	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.E753Q|MFN1_uc010hxc.2_Missense_Mutation_p.E467Q	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	725	Cytoplasmic (Potential).|Potential.				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ACTTGAAAATGAGCTGGAGAA	0.313													0	0	0	0.004672	0	3	48										C	179109794	G	C	179109794	3	2	56	1	0	0	0	0	1	0	0	0	9523	1291	45	1	2239	1	MFN1	3	179109794	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	23894603	179109794	18912636	46	16278										
VPS8	23355	broad.mit.edu	37	chr3	184714261	184714261	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agcagtacaagagacgccaaGaaatggctgatgaaataatt	10	6	0	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:184714261G>C	uc003fpb.1	+	43	3973	c.3802G>C	c.(3802-3804)GAA>CAA	p.E1268Q	VPS8_uc010hyd.1_Missense_Mutation_p.E1178Q|VPS8_uc010hye.1_Missense_Mutation_p.E697Q	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1270	RING-type; atypical.						zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GAGACGCCAAGAAATGGCTGA	0.418													0	0	0	0.009096	0	4	42										C	184714261	G	C	184714261	3	2	56	1	0	0	0	0	1	0	0	0	17215	943	33	1	3974	1	VPS8	3	184714261	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	5604467	184714261	13308169	47	16279										
MAP3K13	9175	broad.mit.edu	37	chr3	185200201	185200201	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agatggggagtgttctgatgCcacagttaggaccaataaac	12	7	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:185200201C>G	uc010hyf.2	+	15	3124	c.2858C>G	c.(2857-2859)GCC>GGC	p.A953G	MAP3K13_uc011brt.1_Missense_Mutation_p.A746G|MAP3K13_uc011bru.1_Missense_Mutation_p.A809G|MAP3K13_uc003fpi.2_Missense_Mutation_p.A953G|MAP3K13_uc010hyg.2_Missense_Mutation_p.A643G	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	953					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			TGTTCTGATGCCACAGTTAGG	0.433													0	0	0	0.001168	0	4	245										G	185200201	C	G	185200201	3	3	56	1	0	0	0	0	1	0	0	0	9247	739	26	4	2908	4	MAP3K13	3	185200201	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	485940	185200201	12822229	48	16280										
TNK2	10188	broad.mit.edu	37	chr3	195610067	195610067	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agcaccaccccgtagaggcgGatgaggtttcggtggtcgag	16	10	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr3:195610067G>A	uc003fvu.1	-	5	1113	c.570C>T	c.(568-570)ATC>ATT	p.I190I	TNK2_uc003fvs.1_Silent_p.I222I|TNK2_uc003fvt.1_Silent_p.I253I|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Silent_p.I20I|TNK2_uc010hzx.1_Silent_p.I204I	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	190	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CGTAGAGGCGGATGAGGTTTC	0.632													0	0	0	0.008871	0	17	96										A	195610067	G	A	195610067	2	1	56	1	0	0	0	0	0	0	0	1	16315	1164	41	1		1	TNK2	3	195610067	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	10409866	195610067	2412363	49	16281										
SLC4A4	8671	broad.mit.edu	37	chr4	72400084	72400084	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	attacagctgtgattgtaaaCaggaaagaacataaactcaa	7	6	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:72400084C>T	uc003hfy.2	+	18	2538	c.2421C>T	c.(2419-2421)AAC>AAT	p.N807N	SLC4A4_uc010iic.2_Silent_p.N807N|SLC4A4_uc010iib.2_Silent_p.N807N|SLC4A4_uc003hfz.2_Silent_p.N807N|SLC4A4_uc003hgc.3_Silent_p.N763N|SLC4A4_uc010iid.2_Silent_p.N11N	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	807	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			TGATTGTAAACAGGAAAGAAC	0.383													0	0	0	0.00308	0	7	47										T	72400084	C	T	72400084	2	4	56	1	0	0	0	0	0	0	0	1	14656	477	17	2		2	SLC4A4	4	72400084	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		72400084	118754192	50	16282										
SLC4A4	8671	broad.mit.edu	37	chr4	72412136	72412136	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttatatgctccctcatggctCttccgtggtatgtagctgct	9	11	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:72412136C>T	uc003hfy.2	+	19	2629	c.2512C>T	c.(2512-2514)CTT>TTT	p.L838F	SLC4A4_uc010iic.2_Missense_Mutation_p.L838F|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Missense_Mutation_p.L838F|SLC4A4_uc003hgc.3_Missense_Mutation_p.L794F|SLC4A4_uc010iid.2_Missense_Mutation_p.L42F	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	838	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCTCATGGCTCTTCCGTGGTA	0.463													0	0	0	0.014323	0	17	104										T	72412136	C	T	72412136	3	4	56	1	0	0	0	0	1	0	0	0	14656	913	32	1	2703	1	SLC4A4	4	72412136	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	12052	72412136	118742140	51	16283										
HERC5	51191	broad.mit.edu	37	chr4	89385092	89385092	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gagctaagaccctgtttggtGgctgagcttgttgggtatag	15	6	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:89385092G>T	uc003hrt.2	+	6	1020	c.867G>T	c.(865-867)GTG>GTT	p.V289V		NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	289	RCC1 4.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		CCTGTTTGGTGGCTGAGCTTG	0.413													1	0	3.41278e-10	0.00499	3.95303e-10	15	54										T	89385092	G	T	89385092	2	4	56	1	0	0	0	0	0	0	0	1	7061	1335	47	4		4	HERC5	4	89385092	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	16972956	89385092	101769184	52	16284										
KIAA1109	84162	broad.mit.edu	37	chr4	123255651	123255651	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cctttaccttccactgtccaGagcaagactaacaccttact	4	15	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:123255651G>C	uc003ieh.2	+	67	11844	c.11799G>C	c.(11797-11799)CAG>CAC	p.Q3933H	KIAA1109_uc003iem.2_Intron	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3933					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CCACTGTCCAGAGCAAGACTA	0.408													0	0	0	0.007835	0	27	100										C	123255651	G	C	123255651	3	2	56	1	0	0	0	0	1	0	0	0	8208	933	33	1	12065	1	KIAA1109	4	123255651	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	33870559	123255651	67898625	53	16285										
PHF17	79960	broad.mit.edu	37	chr4	129778586	129778586	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tagtgtgcagcctctgcaatGagaagtttggggcctctata	12	8	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:129778586G>T	uc003igk.2	+	8	1238	c.958G>T	c.(958-960)GAG>TAG	p.E320*	PHF17_uc003igj.2_Nonsense_Mutation_p.E320*|PHF17_uc003igl.2_Nonsense_Mutation_p.E308*|PHF17_uc011cgy.1_Nonsense_Mutation_p.E320*|PHF17_uc003igm.2_Nonsense_Mutation_p.E320*	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	320	PHD-type 2; atypical.				apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						CCTCTGCAATGAGAAGTTTGG	0.537													1	0	2.46787e-29	0.01441	2.92633e-29	43	144										T	129778586	G	T	129778586	4	4	56	1	0	0	0	0	0	1	0	0	11828	1291	45	3	984	3	PHF17	4	129778586	Nonsense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	6522935	129778586	61375690	54	16286										
RNF150	57484	broad.mit.edu	37	chr4	141888843	141888843	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	taaaagacgagccatgcgagGgaaatgatcatcaggacaat	11	7	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:141888843G>T	uc003iio.1	-	2	1323	c.669C>A	c.(667-669)TCC>TCA	p.S223S	RNF150_uc010iok.1_Intron|RNF150_uc003iip.1_Silent_p.S223S	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	223	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					GCCATGCGAGGGAAATGATCA	0.423													1	0	1.99824e-07	0.00499	2.22026e-07	17	92										T	141888843	G	T	141888843	2	4	56	1	0	0	0	0	0	0	0	1	13451	1219	43	4		4	RNF150	4	141888843	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	12110257	141888843	49265433	55	16287										
GRIA2	2891	broad.mit.edu	37	chr4	158281083	158281083	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtgtttgataaaatgtggacCtacatgcggagtgcggagcc	14	7	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr4:158281083C>T	uc003ipm.3	+	13	2538	c.2079C>T	c.(2077-2079)ACC>ACT	p.T693T	GRIA2_uc011cit.1_Silent_p.T646T|GRIA2_uc003ipl.3_Silent_p.T693T|GRIA2_uc003ipk.3_Silent_p.T646T|GRIA2_uc010iqh.1_RNA|GRIA2_uc011ciu.1_Silent_p.T3T|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_Silent_p.T3T|GRIA2_uc011ciy.1_Silent_p.T3T|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	693	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AAATGTGGACCTACATGCGGA	0.468													0	0	0	0.001984	0	7	17										T	158281083	C	T	158281083	2	4	56	1	0	0	0	0	0	0	0	1	6768	668	24	2		2	GRIA2	4	158281083	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	16392240	158281083	32873193	56	16288										
RNASEN	29102	broad.mit.edu	37	chr5	31472255	31472255	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cccactgaagcatattggcaAtctcctcctcaggcaccagg	8	15	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:31472255A>G	uc003jhg.2	-	16	2515	c.2156T>C	c.(2155-2157)ATT>ACT	p.I719T	RNASEN_uc003jhh.2_Missense_Mutation_p.I682T|RNASEN_uc003jhi.2_Missense_Mutation_p.I682T	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	719	Necessary for interaction with DGCR8 and pri-miRNA processing activity.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						CATATTGGCAATCTCCTCCTC	0.512													0	0	0	0.006999	0	32	130										G	31472255	A	G	31472255	3	3	56	1	0	0	0	0	1	0	0	0	13417	101	4	5	2048	5	RNASEN	5	31472255	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08		31472255	149443005	57	16289										
FST	10468	broad.mit.edu	37	chr5	52780943	52780943	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtgccctgacagtaagtcgGatgagcctgtctgtgccagt	13	10	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:52780943G>C	uc003jpd.2	+	5	865	c.838G>C	c.(838-840)GAT>CAT	p.D280H	FST_uc003jpc.2_Missense_Mutation_p.D280H	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	280	Kazal-like 3.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CAGTAAGTCGGATGAGCCTGT	0.522													0	0	0	0.015359	0	31	60										C	52780943	G	C	52780943	3	2	56	1	0	0	0	0	1	0	0	0	6076	1174	41	1	856	1	FST	5	52780943	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	21308688	52780943	128134317	58	16290										
ERBB2IP	55914	broad.mit.edu	37	chr5	65290597	65290597	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	actttttaactgtcagtcttTacacaaactgagtttgccag	6	9	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:65290597T>C	uc003juk.1	+	4	520	c.212T>C	c.(211-213)TTA>TCA	p.L71S	ERBB2IP_uc003juh.1_Missense_Mutation_p.L71S|ERBB2IP_uc003jui.1_Missense_Mutation_p.L71S|ERBB2IP_uc003juj.1_Missense_Mutation_p.L71S|ERBB2IP_uc011cqx.1_Missense_Mutation_p.L71S|ERBB2IP_uc011cqy.1_Missense_Mutation_p.L71S|ERBB2IP_uc011cqz.1_Missense_Mutation_p.L71S|ERBB2IP_uc010iwx.1_Missense_Mutation_p.L71S|ERBB2IP_uc003jul.1_Missense_Mutation_p.L71S	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	71	LRR 3.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGTCAGTCTTTACACAAACTG	0.333													0	0	0	0.014758	0	5	7										C	65290597	T	C	65290597	3	2	56	1	0	0	0	0	1	0	0	0	5207	1764	61	5	218	5	ERBB2IP	5	65290597	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	12509654	65290597	115624663	59	16291										
FNIP1	96459	broad.mit.edu	37	chr5	130987673	130987673	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tacagacagcttctgctattGgttcatccaaaactggatgc	8	10	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:130987673G>C	uc003kvs.1	-	16	3270	c.3128C>G	c.(3127-3129)CCA>CGA	p.P1043R	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.P1015R	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	1043					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTCTGCTATTGGTTCATCCAA	0.363													0	0	0	0.008291	0	9	52										C	130987673	G	C	130987673	3	2	56	1	0	0	0	0	1	0	0	0	5975	1348	47	4	384	4	FNIP1	5	130987673	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	65697076	130987673	49927587	60	16292										
PCDHGA3	56112	broad.mit.edu	37	chr5	140723652	140723652	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaggactggccctgctgtgcGcgctcctggggacgctgtgc	17	13	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:140723652G>A	uc003ljm.1	+	1	52	c.52G>A	c.(52-54)GCG>ACG	p.A18T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.A18T	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	18					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCTGTGCGCGCTCCTGGG	0.537											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	5	227										A	140723652	G	A	140723652	3	1	56	1	0	0	0	0	1	0	0	0	11555	1087	38	2	54	2	PCDHGA3	5	140723652	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9735979	140723652	40191608	61	16293										
PCDH1	5097	broad.mit.edu	37	chr5	141244926	141244926	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagaagacgcctcacaacttCgggcgcctggtggaatgtgt	13	10	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:141244926C>T	uc003llq.2	-	3	1087	c.970G>A	c.(970-972)GAA>AAA	p.E324K	PCDH1_uc003llp.2_Missense_Mutation_p.E324K|PCDH1_uc011dbf.1_Missense_Mutation_p.E302K	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	324	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CTCACAACTTCGGGCGCCTGG	0.532													0	0	0	0.016723	0	13	77										T	141244926	C	T	141244926	3	4	56	1	0	0	0	0	1	0	0	0	11506	893	31	1	2839	1	PCDH1	5	141244926	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	521274	141244926	39670334	62	16294										
FAT2	2196	broad.mit.edu	37	chr5	150889707	150889707	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgttcacagtgcttcccagaGaactgtgggggacatttgca	12	9	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:150889707G>A	uc003lue.3	-	21	11947	c.11934C>T	c.(11932-11934)TTC>TTT	p.F3978F	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Silent_p.F585F	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3978	Extracellular (Potential).|EGF-like 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCCCAGAGAACTGTGGGG	0.522													0	0	0	0.01441	0	36	96										A	150889707	G	A	150889707	2	1	56	1	0	0	0	0	0	0	0	1	5690	933	33	1		1	FAT2	5	150889707	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9644781	150889707	30025553	63	16295										
HK3	3101	broad.mit.edu	37	chr5	176308338	176308338	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tagagcgttccatccaccccCacagacactgccagctcttc	6	18	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr5:176308338C>G	uc003mfa.2	-	18	2684	c.2592G>C	c.(2590-2592)GTG>GTC	p.V864V	HK3_uc003mez.2_Silent_p.V420V	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	864	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATCCACCCCCACAGACACTG	0.682													0	0	0	0.007835	0	33	237										G	176308338	C	G	176308338	2	3	56	1	0	0	0	0	0	0	0	1	7192	581	21	4		4	HK3	5	176308338	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	25418631	176308338	4606922	64	16296										
FOXF2	2295	broad.mit.edu	37	chr6	1390493	1390493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcccgagaagccgccctactCgtacatcgcgctcatcgtca	9	17	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:1390493C>T	uc003mtm.2	+	1	425	c.311C>T	c.(310-312)TCG>TTG	p.S104L	FOXF2_uc003mtn.2_Missense_Mutation_p.S104L	NM_001452	NP_001443	Q12947	FOXF2_HUMAN	forkhead box F2	104	Fork-head.				epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		CCGCCCTACTCGTACATCGCG	0.517													0	0	0	0.00308	0	6	23										T	1390493	C	T	1390493	3	4	56	1	0	0	0	0	1	0	0	0	6006	893	31	1	313	1	FOXF2	6	1390493	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		1390493	169724574	65	16297										
FAM50B	26240	broad.mit.edu	37	chr6	3850302	3850302	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cctggtcagggagcgcgagcGgcagctggccaagcgccagc	17	14	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:3850302G>T	uc003mvu.2	+	2	369	c.257G>T	c.(256-258)CGG>CTG	p.R86L		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	86						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				GAGCGCGAGCGGCAGCTGGCC	0.532													1	0	9.31168e-06	0.016723	1.01582e-05	14	6										T	3850302	G	T	3850302	3	4	56	1	0	0	0	0	1	0	0	0	5578	1116	39	4	259	4	FAM50B	6	3850302	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2459809	3850302	167264765	66	16298										
KDM1B	221656	broad.mit.edu	37	chr6	18212781	18212781	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	attcagtttaatccaccgttGtcagagaagaagatgaaggc	10	7	2	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:18212781G>A	uc003nco.1	+	11	1395	c.1320G>A	c.(1318-1320)TTG>TTA	p.L440L	KDM1B_uc003ncn.1_Silent_p.L411L|KDM1B_uc003ncp.1_5'UTR|KDM1B_uc003ncq.1_5'UTR	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	643					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						ATCCACCGTTGTCAGAGAAGA	0.403													0	0	0	0.020292	0	14	142										A	18212781	G	A	18212781	2	1	56	1	0	0	0	0	0	0	0	1	8123	1368	48	2		2	KDM1B	6	18212781	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	14362479	18212781	152902286	67	16299										
OR2B3	442184	broad.mit.edu	37	chr6	29054200	29054200	+	Frame_Shift_Del	DEL	G	G	-													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtgatgattccatagaagaGggaaaccatctttccccagt							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:29054200delG	uc003nlx.2	-	1	891	c.826delC	c.(826-828)CTCfs	p.L276fs		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						CCATAGAAGAGGGAAACCATC	0.433																		7	35	---	---								-	29054200	G	-	29054200	7	5	56	1	0	1	0	1	0	0	0	0	10990	1000	35	0	119	0	OR2B3	6	29054200	Frame_Shift_Del	DEL	G	TCGA-DK-A3IK-01A-32D-A21A-08	10841419	29054200	142060867	68	16300										
HLA-E	3133	broad.mit.edu	37	chr6	30459140	30459140	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggagaggagcagagatacacGtgccatgtgcagcatgaggg	17	7	0	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:30459140G>C	uc003nqg.2	+	4	875	c.837G>C	c.(835-837)ACG>ACC	p.T279T	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Silent_p.T320T	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	279	Ig-like C1-type.|Alpha-3.|Extracellular (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						AGAGATACACGTGCCATGTGC	0.622													0	0	0	0.004672	0	3	110										C	30459140	G	C	30459140	2	2	56	1	0	0	0	0	0	0	0	1	7210	1132	40	4		4	HLA-E	6	30459140	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1404940	30459140	140655927	69	16301										
C6orf27	80737	broad.mit.edu	37	chr6	31734367	31734367	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acagcagcgtgggcgacagcGaggctgcgaggagacctcgc	17	12	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:31734367G>A	uc011dog.1	-	14	2295	c.2057C>T	c.(2056-2058)TCG>TTG	p.S686L	C6orf27_uc003nxd.2_Missense_Mutation_p.S361L	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	686						extracellular region				ovary(3)	3						GGGCGACAGCGAGGCTGCGAG	0.692													0	0	0	0.009096	0	3	57										A	31734367	G	A	31734367	3	1	56	1	0	0	0	0	1	0	0	0	2362	1059	37	1	633	1	C6orf27	6	31734367	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1275227	31734367	139380700	70	16302										
ZNF76	7629	broad.mit.edu	37	chr6	35262967	35262967	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggccatcaatgtggccactgCggccatgcagcaaggggctg	15	12	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:35262967C>T	uc003oki.1	+	14	1860	c.1655C>T	c.(1654-1656)GCG>GTG	p.A552V	ZNF76_uc003okj.1_Missense_Mutation_p.A497V|DEF6_uc003okk.2_5'Flank|DEF6_uc010jvs.2_5'Flank|DEF6_uc010jvt.2_5'Flank	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	552					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTGGCCACTGCGGCCATGCAG	0.607													0	0	0	0.004482	0	7	18										T	35262967	C	T	35262967	3	4	56	1	0	0	0	0	1	0	0	0	18132	768	27	2	1705	2	ZNF76	6	35262967	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3528600	35262967	135852100	71	16303										
C6orf81	221481	broad.mit.edu	37	chr6	35716570	35716570	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cctgcaaggtcattgtcagcCtgcagtatccccaggacttg	10	13	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:35716570C>G	uc003ola.2	+	6	1054	c.1027C>G	c.(1027-1029)CTG>GTG	p.L343V	C6orf81_uc003olb.1_Missense_Mutation_p.L306V	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	316	ARM 3.						binding			ovary(1)	1						CATTGTCAGCCTGCAGTATCC	0.532													0	0	0	0.012213	0	30	85										G	35716570	C	G	35716570	3	3	56	1	0	0	0	0	1	0	0	0	2372	680	24	4	1049	4	C6orf81	6	35716570	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	453603	35716570	135398497	72	16304										
NFYA	4800	broad.mit.edu	37	chr6	41051837	41051837	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tggaggccagctaatcacatCaactggccaacccatcatgg	9	13	3	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:41051837C>T	uc003opo.2	+	4	393	c.215C>T	c.(214-216)TCA>TTA	p.S72L	NFYA_uc003opp.2_Missense_Mutation_p.S43L|NFYA_uc003opq.2_Missense_Mutation_p.S43L	NM_002505	NP_002496	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha isoform 1	72	Gln-rich.				transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTAATCACATCAACTGGCCAA	0.453													0	0	0	0.010729	0	10	58										T	41051837	C	T	41051837	3	4	56	1	0	0	0	0	1	0	0	0	10389	838	29	1	225	1	NFYA	6	41051837	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	5335267	41051837	130063230	73	16305										
GSTA1	2938	broad.mit.edu	37	chr6	52659018	52659018	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tggacatacgggcagaaggaGgatcatttcacccaaatctg	11	9	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:52659018G>C	uc003paz.2	-	5	431	c.319C>G	c.(319-321)CTC>GTC	p.L107V		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	107	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GGCAGAAGGAGGATCATTTCA	0.378													0	0	0	0.008871	0	20	83										C	52659018	G	C	52659018	3	2	56	1	0	0	0	0	1	0	0	0	6830	1000	35	4	361	4	GSTA1	6	52659018	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	11607181	52659018	118456049	74	16306										
GSTA5	221357	broad.mit.edu	37	chr6	52701126	52701126	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgcaccagcttcatcccgtcAatctcaaccattggtacttg	6	14	3	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:52701126A>C	uc003pba.1	-	4	250	c.180T>G	c.(178-180)ATT>ATG	p.I60M		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	60	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	TCATCCCGTCAATCTCAACCA	0.433													0	0	0	0.016723	0	13	72										C	52701126	A	C	52701126	3	2	56	1	0	0	0	0	1	0	0	0	6834	126	5	5	504	5	GSTA5	6	52701126	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	42108	52701126	118413941	75	16307										
TINAG	27283	broad.mit.edu	37	chr6	54173466	54173466	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cttatttcactaggaatcacAccgttttgcaaggtactcga	7	10	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:54173466A>C	uc003pcj.2	+	1	264	c.118A>C	c.(118-120)ACC>CCC	p.T40P	TINAG_uc003pci.2_Missense_Mutation_p.T40P|TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	40					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TAGGAATCACACCGTTTTGCA	0.398													0	0	0	0.016522	0	22	46										C	54173466	A	C	54173466	3	2	56	1	0	0	0	0	1	0	0	0	15918	159	6	5	120	5	TINAG	6	54173466	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	1472340	54173466	116941601	76	16308										
ENPP1	5167	broad.mit.edu	37	chr6	132207839	132207839	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agctttcattttgcctcacaGgactgataacagcgagagct	9	10	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:132207839G>A	uc011ecf.1	+	24	2602	c.2582G>A	c.(2581-2583)AGG>AAG	p.R861K		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	861	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	TTGCCTCACAGGACTGATAAC	0.388													0	0	0	0.008871	0	16	40										A	132207839	G	A	132207839	3	1	56	1	0	0	0	0	1	0	0	0	5129	1000	35	2	2676	2	ENPP1	6	132207839	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	78034373	132207839	38907228	77	16309										
PBOV1	59351	broad.mit.edu	37	chr6	138539184	138539184	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagacagcattccagacctaGggtctgagttaactgcaaag	10	9	1	3	rs67796103		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:138539184G>C	uc003qhv.2	-	1	444	c.349C>G	c.(349-351)CTA>GTA	p.L117V	KIAA1244_uc003qhu.2_Intron	NM_021635	NP_067648	Q9GZY1	PBOV1_HUMAN	prostate and breast cancer overexpressed 1	117						cytoplasm|nucleus					0	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00055)|GBM - Glioblastoma multiforme(68;0.000674)		TCCAGACCTAGGGTCTGAGTT	0.388													0	0	0	0.010729	0	9	34										C	138539184	G	C	138539184	3	2	56	1	0	0	0	0	1	0	0	0	11490	991	35	4	62	4	PBOV1	6	138539184	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	6331345	138539184	32575883	78	16310										
TCP1	6950	broad.mit.edu	37	chr6	160210477	160210477	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tccccagtgctgcggtcaccGaacacggacaaaggcccctc	10	17	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:160210477G>A	uc003qsr.2	-	1	259	c.24C>T	c.(22-24)TTC>TTT	p.F8F	TCP1_uc003qss.2_5'UTR|TCP1_uc010kjz.2_Silent_p.F8F|TCP1_uc003qst.2_5'UTR|TCP1_uc010kka.1_RNA|MRPL18_uc010kkb.2_5'Flank|MRPL18_uc003qsw.3_5'Flank	NM_030752	NP_110379	P17987	TCPA_HUMAN	T-complex protein 1 isoform a	8					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TGCGGTCACCGAACACGGACA	0.677													0	0	0	0.016723	0	11	59										A	160210477	G	A	160210477	2	1	56	1	0	0	0	0	0	0	0	1	15706	1049	37	1		1	TCP1	6	160210477	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	21671293	160210477	10904590	79	16311										
PDE10A	10846	broad.mit.edu	37	chr6	165746546	165746546	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgcagctgccttctgagccaCggatggggatgaaatccagg	14	10	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:165746546C>T	uc003qun.2	-	23	2549	c.2308G>A	c.(2308-2310)GTG>ATG	p.V770M	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.V700M|PDE10A_uc003quo.2_Missense_Mutation_p.V780M	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	770					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TTCTGAGCCACGGATGGGGAT	0.498													0	0	0	0.004656	0	21	113										T	165746546	C	T	165746546	3	4	56	1	0	0	0	0	1	0	0	0	11630	536	19	2	35	2	PDE10A	6	165746546	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	5536069	165746546	5368521	80	16312										
MLLT4	4301	broad.mit.edu	37	chr6	168272964	168272964	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaacttcaagagaactctctCaaagaaagaaaagaaggaaa	8	6	3	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr6:168272964C>G	uc003qwd.2	+	4	624	c.482C>G	c.(481-483)TCA>TGA	p.S161*	MLLT4_uc003qwb.1_Nonsense_Mutation_p.S161*|MLLT4_uc003qwc.1_Nonsense_Mutation_p.S162*	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	162	Potential.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AGAACTCTCTCaaagaaagaa	0.333			T	MLL	AL								0	0	0	0.00308	0	7	32										G	168272964	C	G	168272964	4	3	56	1	0	0	0	0	0	1	0	0	9629	838	29	1	499	1	MLLT4	6	168272964	Nonsense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2526418	168272964	2842103	81	16313										
TTYH3	80727	broad.mit.edu	37	chr7	2687635	2687635	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctgctgctggacgtcatcatCtgcctcctggtgctggttgg	13	12	3	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:2687635C>G	uc003smp.2	+	5	856	c.669C>G	c.(667-669)ATC>ATG	p.I223M	TTYH3_uc010ksn.2_Intron|TTYH3_uc003smq.2_Missense_Mutation_p.I52M	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	223	Helical; Name=3; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		ACGTCATCATCTGCCTCCTGG	0.701													0	0	0	0.00874	0	31	158										G	2687635	C	G	2687635	3	3	56	1	0	0	0	0	1	0	0	0	16738	903	32	1	687	1	TTYH3	7	2687635	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		2687635	156451028	82	16314										
ZDHHC4	55146	broad.mit.edu	37	chr7	6624725	6624725	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	catcggggcctggaacatcaGgtacttcctcatctacgtct	9	13	4	0	rs141408179		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:6624725G>C	uc003sqi.2	+	8	933	c.575G>C	c.(574-576)AGG>ACG	p.R192T	ZDHHC4_uc003sql.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqh.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqj.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqk.2_Missense_Mutation_p.R192T|ZDHHC4_uc003sqm.2_Missense_Mutation_p.R192T	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	192	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGGAACATCAGGTACTTCCTC	0.537													0	0	0	0.003163	0	12	61										C	6624725	G	C	6624725	3	2	56	1	0	0	0	0	1	0	0	0	17614	1000	35	4	593	4	ZDHHC4	7	6624725	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	3937090	6624725	152513938	83	16315										
SCIN	85477	broad.mit.edu	37	chr7	12668812	12668812	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggtgactgctacatcatactCtacacctatcccagaggaca	7	13	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:12668812C>G	uc003ssn.3	+	9	1494	c.1284C>G	c.(1282-1284)CTC>CTG	p.L428L	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Silent_p.L181L	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	428	Ca(2+)-dependent actin binding.|Gelsolin-like 4.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ACATCATACTCTACACCTATC	0.418													0	0	0	0.009535	0	24	98										G	12668812	C	G	12668812	2	3	56	1	0	0	0	0	0	0	0	1	13905	900	32	1		1	SCIN	7	12668812	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	6044087	12668812	146469851	84	16316										
C7orf36	57002	broad.mit.edu	37	chr7	39612143	39612143	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tttaacaaaaactgtagcaaGagccatagtgggatagattg	10	5	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:39612143G>C	uc003thc.3	+	3	528	c.519G>C	c.(517-519)AAG>AAC	p.K173N		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	173											0						ACTGTAGCAAGAGCCATAGTG	0.393													0	0	0	0.020292	0	13	100										C	39612143	G	C	39612143	3	2	56	1	0	0	0	0	1	0	0	0	2390	933	33	1	529	1	C7orf36	7	39612143	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	26943331	39612143	119526520	85	16317										
PSPH	5723	broad.mit.edu	37	chr7	56082826	56082826	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttttccttttccaccagattCagctgttggctgcgtctcat	7	12	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:56082826C>T	uc003trg.2	-	6	823	c.460G>A	c.(460-462)GAA>AAA	p.E154K	PSPH_uc003trh.2_Missense_Mutation_p.E154K|PSPH_uc003tri.2_Missense_Mutation_p.E154K|PSPH_uc003trj.2_Missense_Mutation_p.E183K	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	154					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CCACCAGATTCAGCTGTTGGC	0.363													0	0	0	0.001984	0	7	37										T	56082826	C	T	56082826	3	4	56	1	0	0	0	0	1	0	0	0	12717	835	29	1	225	1	PSPH	7	56082826	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	16470683	56082826	103055837	86	16318										
SEMA3D	223117	broad.mit.edu	37	chr7	84671545	84671545	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggaattgagcaaatcagtctGgccttaagaaaagtcgtcca	10	8	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:84671545G>C	uc003uic.2	-	8	958	c.918C>G	c.(916-918)GCC>GCG	p.A306A	SEMA3D_uc010led.2_Silent_p.A306A|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	306	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						AAATCAGTCTGGCCTTAAGAA	0.383													0	0	0	0.01441	0	65	81										C	84671545	G	C	84671545	2	2	56	1	0	0	0	0	0	0	0	1	14027	1335	47	4		4	SEMA3D	7	84671545	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	28588719	84671545	74467118	87	16319										
PTCD1	26024	broad.mit.edu	37	chr7	99022928	99022928	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtatccacctctggttgggcCttgccgggcactctggcttc	12	14	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99022928C>G	uc003uqh.2	-	6	1358	c.1227G>C	c.(1225-1227)AAG>AAC	p.K409N	PTCD1_uc011kiw.1_Missense_Mutation_p.K458N	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	409										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			CTGGTTGGGCCTTGCCGGGCA	0.637													0	0	0	0.006999	0	32	107										G	99022928	C	G	99022928	3	3	56	1	0	0	0	0	1	0	0	0	12727	680	24	4	887	4	PTCD1	7	99022928	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	14351383	99022928	60115735	88	16320										
ZNF498	221785	broad.mit.edu	37	chr7	99220228	99220228	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cagtgaatcccagagaccaaGagatggcagctgggttcttt	12	9	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99220228G>C	uc003url.1	+	6	973	c.646G>C	c.(646-648)GAG>CAG	p.E216Q	ZNF498_uc003urm.1_Missense_Mutation_p.E52Q|ZNF498_uc010lge.1_Missense_Mutation_p.E52Q|ZNF498_uc003urn.2_RNA|ZNF498_uc010lgf.1_Intron|ZNF498_uc003uro.1_5'UTR	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	216					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CAGAGACCAAGAGATGGCAGC	0.532													0	0	0	0.007291	0	30	85										C	99220228	G	C	99220228	3	2	56	1	0	0	0	0	1	0	0	0	17944	943	33	1	656	1	ZNF498	7	99220228	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	197300	99220228	59918435	89	16321										
ZNF498	221785	broad.mit.edu	37	chr7	99227017	99227017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtgccatccccctgcctgacGaagtcaaaacccacagctcc	7	18	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99227017G>A	uc003url.1	+	8	1336	c.1009G>A	c.(1009-1011)GAA>AAA	p.E337K	ZNF498_uc003urm.1_Missense_Mutation_p.E173K|ZNF498_uc010lge.1_Missense_Mutation_p.E173K|ZNF498_uc003urn.2_Intron|ZNF498_uc010lgf.1_Missense_Mutation_p.E265K|ZNF498_uc003uro.1_Missense_Mutation_p.E121K	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	337					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CCTGCCTGACGAAGTCAAAAC	0.632													0	0	0	0.003163	0	13	32										A	99227017	G	A	99227017	3	1	56	1	0	0	0	0	1	0	0	0	17944	1059	37	1	1027	1	ZNF498	7	99227017	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	6789	99227017	59911646	90	16322										
ZNF498	221785	broad.mit.edu	37	chr7	99227062	99227062	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggaagcctttccagtgccctGagtgtgggaaaggattcagt	14	8	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:99227062G>T	uc003url.1	+	8	1381	c.1054G>T	c.(1054-1056)GAG>TAG	p.E352*	ZNF498_uc003urm.1_Nonsense_Mutation_p.E188*|ZNF498_uc010lge.1_Nonsense_Mutation_p.E188*|ZNF498_uc003urn.2_Intron|ZNF498_uc010lgf.1_Nonsense_Mutation_p.E280*|ZNF498_uc003uro.1_Nonsense_Mutation_p.E136*	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	352	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					CCAGTGCCCTGAGTGTGGGAA	0.587													1	0	1.5842e-08	0.016723	1.78669e-08	13	44										T	99227062	G	T	99227062	4	4	56	1	0	0	0	0	0	1	0	0	17944	1291	45	3	1072	3	ZNF498	7	99227062	Nonsense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	45	99227062	59911601	91	16323										
MUC17	140453	broad.mit.edu	37	chr7	100684992	100684992	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctccaacactctggtgaccaCttctactgaagccagttcat	6	14	3	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:100684992C>G	uc003uxp.1	+	3	10348	c.10295C>G	c.(10294-10296)ACT>AGT	p.T3432S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3432	Extracellular (Potential).|Ser-rich.|56.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGGTGACCACTTCTACTGAA	0.488													0	0	0	0.001168	0	4	286										G	100684992	C	G	100684992	3	3	56	1	0	0	0	0	1	0	0	0	9974	565	20	4	10305	4	MUC17	7	100684992	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1457930	100684992	58453671	92	16324										
CNTNAP2	26047	broad.mit.edu	37	chr7	147600711	147600711	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	caacgagaagcactactactGgggaggctctgggcctggaa	14	10	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:147600711G>A	uc003weu.1	+	14	2669	c.2153G>A	c.(2152-2154)TGG>TAG	p.W718*		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	718	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CACTACTACTGGGGAGGCTCT	0.507										HNSCC(39;0.1)			0	0	0	0.001168	0	4	25										A	147600711	G	A	147600711	4	1	56	1	0	0	0	0	0	1	0	0	3647	1357	47	2	2207	2	CNTNAP2	7	147600711	Nonsense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	46915719	147600711	11537952	93	16325										
SSPO	23145	broad.mit.edu	37	chr7	149489422	149489422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagggcaggtgctgggcagcGaggggtggtgtgtgtggccc	22	7	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:149489422G>A	uc010lpk.2	+	38	5575	c.5575G>A	c.(5575-5577)GAG>AAG	p.E1859K		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1859	EGF-like 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCTGGGCAGCGAGGGGTGGTG	0.687													0	0	0	0.00308	0	5	9										A	149489422	G	A	149489422	3	1	56	1	0	0	0	0	1	0	0	0	15188	1059	37	1	5717	1	SSPO	7	149489422	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1888711	149489422	9649241	94	16326										
UBE3C	9690	broad.mit.edu	37	chr7	157000422	157000422	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggtcaaagacaatcatcaatGatgccttttactttagaaga	7	7	3	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr7:157000422G>C	uc010lqs.2	+	13	1914	c.1602G>C	c.(1600-1602)ATG>ATC	p.M534I	UBE3C_uc003wng.2_Missense_Mutation_p.M534I	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	534					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		AATCATCAATGATGCCTTTTA	0.373													0	0	0	0.008291	0	8	46										C	157000422	G	C	157000422	3	2	56	1	0	0	0	0	1	0	0	0	16878	1290	45	1	1652	1	UBE3C	7	157000422	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	7511000	157000422	2138241	95	16327										
CHRNB3	1142	broad.mit.edu	37	chr8	42586933	42586933	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atggacgtcacgtttttcccGttcgaccgacagaactgctc	9	13	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:42586933G>T	uc003xpi.1	+	5	611	c.483G>T	c.(481-483)CCG>CCT	p.P161P		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	161	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CGTTTTTCCCGTTCGACCGAC	0.488													1	0	0.00024832	0.009096	0.000267011	3	41										T	42586933	G	T	42586933	2	4	56	1	0	0	0	0	0	0	0	1	3392	1132	40	4		4	CHRNB3	8	42586933	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		42586933	103777089	96	16328										
PRKDC	5591	broad.mit.edu	37	chr8	48846651	48846651	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcagattcagactcagggccCtggccagaaagacagcatga	11	11	3	5			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:48846651C>G	uc003xqi.2	-	15	1555	c.1498_splice	c.e15-1	p.G500_splice	PRKDC_uc003xqj.2_Splice_Site_p.G500_splice|PRKDC_uc011ldh.1_Splice_Site_p.G500_splice	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACTCAGGGCCCTGGCCAGAAA	0.473								NHEJ					0	0	0	0.009096	0	3	159										G	48846651	C	G	48846651	5	3	56	1	0	0	0	0	0	0	1	0	12521	695	24	4	11176	4	PRKDC	8	48846651	Splice_Site	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	6259718	48846651	97517371	97	16329										
MSC	9242	broad.mit.edu	37	chr8	72755904	72755904	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttcactgggtgcacgtagccGttctcatagcggtcctcctg	11	13	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:72755904G>A	uc003xyx.1	-	1	828	c.510C>T	c.(508-510)AAC>AAT	p.N170N	uc011lff.1_RNA|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	170					transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			GCACGTAGCCGTTCTCATAGC	0.662											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.021523	0	22	85										A	72755904	G	A	72755904	2	1	56	1	0	0	0	0	0	0	0	1	9868	1136	40	2		2	MSC	8	72755904	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	23909253	72755904	73608118	98	16330										
CDH17	1015	broad.mit.edu	37	chr8	95186397	95186397	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tacatgacattgttgatcatGggaagctggatgacaatctg	11	6	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:95186397G>A	uc003ygh.2	-	6	641	c.516C>T	c.(514-516)CCC>CCT	p.P172P	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Silent_p.P172P	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	172	Extracellular (Potential).|Cadherin 2.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGTTGATCATGGGAAGCTGGA	0.488													0	0	0	0.00623	0	37	340										A	95186397	G	A	95186397	2	1	56	1	0	0	0	0	0	0	0	1	3102	1335	47	2		2	CDH17	8	95186397	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	22430493	95186397	51177625	99	16331										
RGS22	26166	broad.mit.edu	37	chr8	101078419	101078419	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aacagatgaaatagctggtgAtttaagtttgttgtagggta	12	2	0	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:101078419A>C	uc003yjb.1	-	7	895	c.700T>G	c.(700-702)TCA>GCA	p.S234A	RGS22_uc003yja.1_Missense_Mutation_p.S53A|RGS22_uc003yjc.1_Missense_Mutation_p.S222A|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	234					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATAGCTGGTGATTTAAGTTTG	0.338													0	0	0	0.010729	0	10	92										C	101078419	A	C	101078419	3	2	56	1	0	0	0	0	1	0	0	0	13305	333	12	5	3178	5	RGS22	8	101078419	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	5892022	101078419	45285603	100	16332										
PABPC1	26986	broad.mit.edu	37	chr8	101721413	101721413	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggacttggtcttagttgagcAatttggctaggaggatagta	14	4	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:101721413A>G	uc003yjs.1	-	9	1788	c.1284T>C	c.(1282-1284)ATT>ATC	p.I428I	PABPC1_uc011lhc.1_Silent_p.I396I|PABPC1_uc011lhd.1_Silent_p.I383I|PABPC1_uc003yjt.1_Silent_p.I425I|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	428				I -> V (in Ref. 1; CAA68428).	mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			TTAGTTGAGCAATTTGGCTAG	0.393													0	0	0	0.01441	0	49	280										G	101721413	A	G	101721413	2	3	56	1	0	0	0	0	0	0	0	1	11363	126	5	5		5	PABPC1	8	101721413	Silent	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	642994	101721413	44642609	101	16333										
ZFPM2	23414	broad.mit.edu	37	chr8	106813404	106813404	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cactcaagctgccttccgatGtaatcactgccatttcggct	7	14	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:106813404G>A	uc003ymd.2	+	8	1117	c.1094G>A	c.(1093-1095)TGT>TAT	p.C365Y	ZFPM2_uc011lhs.1_Missense_Mutation_p.C96Y|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	365	C2H2-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCCTTCCGATGTAATCACTGC	0.502													0	0	0	0.011902	0	41	344										A	106813404	G	A	106813404	3	1	56	1	0	0	0	0	1	0	0	0	17655	1377	48	2	1124	2	ZFPM2	8	106813404	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	5091991	106813404	39550618	102	16334										
CSMD3	114788	broad.mit.edu	37	chr8	113358438	113358438	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tctgacatagcaccaccacaCtgagctgcaaaataacagaa	6	12	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:113358438C>G	uc003ynu.2	-	41	6489	c.6330G>C	c.(6328-6330)CAG>CAC	p.Q2110H	CSMD3_uc003yns.2_Missense_Mutation_p.Q1312H|CSMD3_uc003ynt.2_Missense_Mutation_p.Q2070H|CSMD3_uc011lhx.1_Missense_Mutation_p.Q2006H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2110	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACCACCACACTGAGCTGCAA	0.383										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.009096	0	4	81										G	113358438	C	G	113358438	3	3	56	1	0	0	0	0	1	0	0	0	3946	564	20	4	4917	4	CSMD3	8	113358438	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	6545034	113358438	33005584	103	16335										
ZHX2	22882	broad.mit.edu	37	chr8	123963985	123963985	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aaaaactccaaggtggttatGagtgcaaatactgcccctac	8	10	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:123963985G>C	uc003ypk.1	+	3	802	c.235G>C	c.(235-237)GAG>CAG	p.E79Q		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	79	C2H2-type 1.					cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			AGGTGGTTATGAGTGCAAATA	0.483													0	0	0	0.006214	0	7	94										C	123963985	G	C	123963985	3	2	56	1	0	0	0	0	1	0	0	0	17673	1291	45	1	237	1	ZHX2	8	123963985	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	10605547	123963985	22400037	104	16336										
ADCY8	114	broad.mit.edu	37	chr8	131848566	131848566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ataacgcagaaagaggcctgCgtagacggtctcagtgagca	13	9	1	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:131848566C>T	uc003ytd.3	-	12	2888	c.2632G>A	c.(2632-2634)GCA>ACA	p.A878T	ADCY8_uc010mds.2_Missense_Mutation_p.A747T	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	878	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AAGAGGCCTGCGTAGACGGTC	0.542										HNSCC(32;0.087)			0	0	0	0.01892	0	22	163										T	131848566	C	T	131848566	3	4	56	1	0	0	0	0	1	0	0	0	300	768	27	2	1151	2	ADCY8	8	131848566	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	7884581	131848566	14515456	105	16337										
CYP11B2	1585	broad.mit.edu	37	chr8	143993439	143993439	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggaggggggacgtgccaggcCtcaatatgaagctgtagacc	16	9	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:143993439C>G	uc003yxk.1	-	9	1472	c.1469G>C	c.(1468-1470)AGG>ACG	p.R490T		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	490					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CGTGCCAGGCCTCAATATGAA	0.562									Familial_Hyperaldosteronism_type_I				0	0	0	0.006122	0	14	147										G	143993439	C	G	143993439	3	3	56	1	0	0	0	0	1	0	0	0	4146	681	24	4	46	4	CYP11B2	8	143993439	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	12144873	143993439	2370583	106	16338										
NFKBIL2	4796	broad.mit.edu	37	chr8	145665527	145665527	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gagctcccgtagtctggtttCggtctcaggggcctcctggg	15	12	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr8:145665527C>T	uc011llg.1	-	11	1372	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K		NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	453	Glu-rich.				cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGTCTGGTTTCGGTCTCAGGG	0.522													0	0	0	0.01441	0	32	112										T	145665527	C	T	145665527	3	4	56	1	0	0	0	0	1	0	0	0	10382	893	31	1	2843	1	NFKBIL2	8	145665527	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1672088	145665527	698495	107	16339										
PTPRD	5789	broad.mit.edu	37	chr9	8500765	8500765	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcaacataccatcttcattgGttcgaatcaacacggacaag	7	11	3	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:8500765G>C	uc003zkk.2	-	23	2828	c.2117C>G	c.(2116-2118)ACC>AGC	p.T706S	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.T706S|PTPRD_uc003zkm.2_Missense_Mutation_p.T693S|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	706	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATCTTCATTGGTTCGAATCAA	0.478										TSP Lung(15;0.13)			0	0	0	0.013726	0	29	51										C	8500765	G	C	8500765	3	2	56	1	0	0	0	0	1	0	0	0	12799	1261	44	4	3781	4	PTPRD	9	8500765	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		8500765	132712666	108	16340										
UBAP2	55833	broad.mit.edu	37	chr9	33941739	33941739	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctggtcataagaggaagacaTtgctactggactagcagaat	11	7	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:33941739T>C	uc003ztq.1	-	16	1950	c.1837A>G	c.(1837-1839)ATG>GTG	p.M613V	UBAP2_uc011loc.1_Missense_Mutation_p.M522V|UBAP2_uc011lod.1_Missense_Mutation_p.M346V|UBAP2_uc011loe.1_Missense_Mutation_p.M368V|UBAP2_uc011lof.1_Missense_Mutation_p.M538V|UBAP2_uc011log.1_Missense_Mutation_p.M559V|UBAP2_uc003ztr.2_Missense_Mutation_p.M485V|UBAP2_uc003zts.2_Missense_Mutation_p.M246V	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	613										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GAGGAAGACATTGCTACTGGA	0.463													0	0	0	0.001984	0	7	54										C	33941739	T	C	33941739	3	2	56	1	0	0	0	0	1	0	0	0	16834	1493	52	5	1578	5	UBAP2	9	33941739	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	25440974	33941739	107271692	109	16341										
ALDH1A1	216	broad.mit.edu	37	chr9	75526950	75526950	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	caaagtagcctttattccccCacgggcctcctccacattcc	5	18	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:75526950C>G	uc004ajd.2	-	10	1177	c.1124G>C	c.(1123-1125)TGG>TCG	p.W375S	ALDH1A1_uc011lsh.1_Missense_Mutation_p.W296S|ALDH1A1_uc011lsg.1_Missense_Mutation_p.W201S	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	375					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTTATTCCCCCACGGGCCTCC	0.433													0	0	0	0.012319	0	18	70										G	75526950	C	G	75526950	3	3	56	1	0	0	0	0	1	0	0	0	490	595	21	4	397	4	ALDH1A1	9	75526950	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	41585211	75526950	65686481	110	16342										
CDC14B	8555	broad.mit.edu	37	chr9	99327675	99327675	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttttaaagagcaatacttacTtctcatattcaagttcatta	3	7	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:99327675T>A	uc004awj.2	-	2	703	c.251A>T	c.(250-252)AAC>ATC	p.N84I	CDC14B_uc004awk.2_Missense_Mutation_p.N84I|CDC14B_uc004awl.2_RNA|CDC14B_uc004awi.2_Missense_Mutation_p.N47I	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	84	A.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CAATACTTACTTCTCATATTC	0.313													0	0	0	0.00308	0	7	40										A	99327675	T	A	99327675	3	1	56	1	0	0	0	0	1	0	0	0	3057	1623	56	5	1297	5	CDC14B	9	99327675	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	23800725	99327675	41885756	111	16343										
ZNF483	158399	broad.mit.edu	37	chr9	114296106	114296106	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttcaaaaggagctatataagGaagtgctactggaaaacctc	9	7	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:114296106G>T	uc004bff.2	+	4	813	c.589G>T	c.(589-591)GAA>TAA	p.E197*	ZNF483_uc011lwq.1_Nonsense_Mutation_p.E197*|ZNF483_uc004bfg.2_Nonsense_Mutation_p.E197*	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	197	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						GCTATATAAGGAAGTGCTACT	0.398													1	0	0.000673444	0.008291	0.00071643	9	29										T	114296106	G	T	114296106	4	4	56	1	0	0	0	0	0	1	0	0	17933	1175	41	3	599	3	ZNF483	9	114296106	Nonsense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	14968431	114296106	26917325	112	16344										
GLE1	2733	broad.mit.edu	37	chr9	131286012	131286012	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgctgcagctcagccagcagCtggatgcctctgagcagcac	12	14	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:131286012C>A	uc004bvj.2	+	6	898	c.784C>A	c.(784-786)CTG>ATG	p.L262M	GLE1_uc004bvi.2_Missense_Mutation_p.L262M|GLE1_uc010myd.2_Missense_Mutation_p.L8M	NM_001003722	NP_001003722	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator homolog isoform 1	262	Potential.				poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding				0						CAGCCAGCAGCTGGATGCCTC	0.612													1	0	1.12685e-05	0.004482	1.22484e-05	8	35										A	131286012	C	A	131286012	3	1	56	1	0	0	0	0	1	0	0	0	6435	796	28	4	806	4	GLE1	9	131286012	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	16989906	131286012	9927419	113	16345										
SPTAN1	6709	broad.mit.edu	37	chr9	131387392	131387392	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cgttttctaggtgaaaaggaGaacagcttgaagacagatga	12	5	1	6			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:131387392G>A	uc004bvl.3	+	46	6101	c.5988G>A	c.(5986-5988)GAG>GAA	p.E1996E	SPTAN1_uc004bvm.3_Silent_p.E2001E|SPTAN1_uc004bvn.3_Silent_p.E1976E|SPTAN1_uc010mye.1_5'Flank|SPTAN1_uc010myf.1_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1996	Spectrin 21.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GTGAAAAGGAGAACAGCTTGA	0.448													0	0	0	0.004482	0	7	48										A	131387392	G	A	131387392	2	1	56	1	0	0	0	0	0	0	0	1	15116	933	33	1		1	SPTAN1	9	131387392	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	101380	131387392	9826039	114	16346										
TBC1D13	54662	broad.mit.edu	37	chr9	131553894	131553894	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gagctgtatgcccagttcctGagggaaatgatcatccagcc	11	11	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:131553894G>C	uc010myj.2	+	5	345	c.222G>C	c.(220-222)CTG>CTC	p.L74L	TBC1D13_uc010myk.2_Silent_p.L74L|TBC1D13_uc010myl.2_Intron	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	74	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0						CCCAGTTCCTGAGGGAAATGA	0.577													0	0	0	0.003163	0	15	65										C	131553894	G	C	131553894	2	2	56	1	0	0	0	0	0	0	0	1	15599	1277	45	1		1	TBC1D13	9	131553894	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	166502	131553894	9659537	115	16347										
PNPLA7	375775	broad.mit.edu	37	chr9	140354928	140354928	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccgcagtgaggactcgtcctCctgcaagcagaccgcatgtt	11	14	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:140354928C>A	uc004cnf.2	-	34	4208	c.3871G>T	c.(3871-3873)GAG>TAG	p.E1291*	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Nonsense_Mutation_p.E538*|PNPLA7_uc004cne.1_Nonsense_Mutation_p.E557*|PNPLA7_uc011mfa.1_Nonsense_Mutation_p.E699*|PNPLA7_uc010ncj.1_Nonsense_Mutation_p.E1316*|NELF_uc011mey.1_5'Flank|NELF_uc004cna.2_5'Flank|NELF_uc011mez.1_5'Flank|NELF_uc004cmz.2_5'Flank|NELF_uc004cnc.2_5'Flank|NELF_uc004cnb.2_5'Flank	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1291					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GACTCGTCCTCCTGCAAGCAG	0.637													1	0	3.65163e-15	0.00632	4.27925e-15	25	28										A	140354928	C	A	140354928	4	1	56	1	0	0	0	0	0	1	0	0	12170	869	30	3	86	3	PNPLA7	9	140354928	Nonsense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	8801034	140354928	858503	116	16348										
PNPLA7	375775	broad.mit.edu	37	chr9	140437237	140437237	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctccaggaacagcggcttctCaaagtggcccaggaccctgc	11	15	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr9:140437237C>T	uc004cnf.2	-	6	785	c.448G>A	c.(448-450)GAG>AAG	p.E150K	PNPLA7_uc010ncj.1_Missense_Mutation_p.E175K	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	150	cNMP 1.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		AGCGGCTTCTCAAAGTGGCCC	0.622													0	0	0	0.00499	0	12	71										T	140437237	C	T	140437237	3	4	56	1	0	0	0	0	1	0	0	0	12170	835	29	1	3621	1	PNPLA7	9	140437237	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	82309	140437237	776194	117	16349										
DHTKD1	55526	broad.mit.edu	37	chr10	12148334	12148334	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aagttactgcccctgtgggaGgcacagtttggcgatttctt	12	9	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:12148334G>T	uc001ild.3	+	11	2085	c.1986G>T	c.(1984-1986)GAG>GAT	p.E662D		NM_018706	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain	662					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			ovary(1)|central_nervous_system(1)	2		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CCCTGTGGGAGGCACAGTTTG	0.527													1	0	0.000157383	0.00308	0.000170451	6	157										T	12148334	G	T	12148334	3	4	56	1	0	0	0	0	1	0	0	0	4500	991	35	4	2028	4	DHTKD1	10	12148334	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		12148334	123386413	118	16350										
CUBN	8029	broad.mit.edu	37	chr10	17083214	17083214	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	attgactattaccacattctCacatgctggaaaaagaaatg	6	8	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:17083214C>T	uc001ioo.2	-	27	3887	c.3835G>A	c.(3835-3837)GAG>AAG	p.E1279K		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1279	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCACATTCTCACATGCTGGA	0.343													0	0	0	0.020292	0	10	74										T	17083214	C	T	17083214	3	4	56	1	0	0	0	0	1	0	0	0	4051	835	29	1	7200	1	CUBN	10	17083214	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	4934880	17083214	118451533	119	16351										
CUBN	8029	broad.mit.edu	37	chr10	17107557	17107557	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttaagaagccttcataagcgAggtcggagtcagtcacaaac	10	9	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:17107557A>T	uc001ioo.2	-	22	3141	c.3089T>A	c.(3088-3090)CTC>CAC	p.L1030H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1030	CUB 5.	Calcium 1; via carbonyl oxygen.			cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTCATAAGCGAGGTCGGAGTC	0.428													0	0	0	0.015359	0	33	196										T	17107557	A	T	17107557	3	4	56	1	0	0	0	0	1	0	0	0	4051	304	11	5	7966	5	CUBN	10	17107557	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	24343	17107557	118427190	120	16352										
STOX1	219736	broad.mit.edu	37	chr10	70645483	70645483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tccgcatagtctgccatcacGaggtgcctccttttcagacc	8	15	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:70645483G>A	uc001jos.2	+	3	2018	c.1931G>A	c.(1930-1932)CGA>CAA	p.R644Q	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.R534Q	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	644						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						CTGCCATCACGAGGTGCCTCC	0.453													0	0	0	0.00632	0	21	73										A	70645483	G	A	70645483	3	1	56	1	0	0	0	0	1	0	0	0	15318	1058	37	1	1941	1	STOX1	10	70645483	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	53537926	70645483	64889264	121	16353										
GBF1	8729	broad.mit.edu	37	chr10	104129518	104129518	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atctctctacagcgggaagaGacaccatcaaaccggtaaga	9	11	3	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:104129518G>C	uc001kux.1	+	25	3438	c.3198G>C	c.(3196-3198)GAG>GAC	p.E1066D	GBF1_uc001kuy.1_Missense_Mutation_p.E1066D|GBF1_uc001kuz.1_Missense_Mutation_p.E1067D	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1066					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AGCGGGAAGAGACACCATCAA	0.483													0	0	0	0.012319	0	16	38										C	104129518	G	C	104129518	3	2	56	1	0	0	0	0	1	0	0	0	6271	933	33	1	3292	1	GBF1	10	104129518	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	33484035	104129518	31405229	122	16354										
GBF1	8729	broad.mit.edu	37	chr10	104142018	104142018	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atcctcaaccctgcgctcatCgaggccacctcaccagtgcc	7	19	3	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr10:104142018C>T	uc001kux.1	+	40	5745	c.5505C>T	c.(5503-5505)ATC>ATT	p.I1835I	GBF1_uc001kuy.1_Silent_p.I1831I|GBF1_uc001kuz.1_Silent_p.I1832I	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1835	Pro-rich.				COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTGCGCTCATCGAGGCCACCT	0.637													0	0	0	0.01441	0	43	160										T	104142018	C	T	104142018	2	4	56	1	0	0	0	0	0	0	0	1	6271	874	31	1		1	GBF1	10	104142018	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	12500	104142018	31392729	123	16355										
OSBPL5	114879	broad.mit.edu	37	chr11	3125474	3125474	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cggagagcttgttcaggaagGagcgcggctccagtacgaac	15	10	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:3125474G>C	uc001lxk.2	-	10	1351	c.1193C>G	c.(1192-1194)TCC>TGC	p.S398C	OSBPL5_uc010qxq.1_Missense_Mutation_p.S309C|OSBPL5_uc009ydw.2_Missense_Mutation_p.S330C|OSBPL5_uc001lxl.2_Missense_Mutation_p.S330C|OSBPL5_uc009ydx.2_Missense_Mutation_p.S422C	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	398					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTTCAGGAAGGAGCGCGGCTC	0.627													0	0	0	0.010504	0	17	48										C	3125474	G	C	3125474	3	2	56	1	0	0	0	0	1	0	0	0	11280	1174	41	1	1498	1	OSBPL5	11	3125474	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		3125474	131881042	124	16356										
OR5I1	10798	broad.mit.edu	37	chr11	55702943	55702943	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgctttatctcatgaagaatCtacctttgatcttagaactt	5	8	3	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:55702943C>G	uc010ris.1	-	1	934	c.934G>C	c.(934-936)GAT>CAT	p.D312H		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CATGAAGAATCTACCTTTGAT	0.353													0	0	0	0.004672	0	3	21										G	55702943	C	G	55702943	3	3	56	1	0	0	0	0	1	0	0	0	11164	913	32	1	13	1	OR5I1	11	55702943	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	52577469	55702943	79303573	125	16357										
OR8K3	219473	broad.mit.edu	37	chr11	56085843	56085843	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttacgggaatcacagatatcGctgagctgcaggcaccatta	10	10	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:56085843G>A	uc010rjf.1	+	1	61	c.61G>A	c.(61-63)GCT>ACT	p.A21T		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					CACAGATATCGCTGAGCTGCA	0.438													0	0	0	0.01441	0	42	102										A	56085843	G	A	56085843	3	1	56	1	0	0	0	0	1	0	0	0	11244	1087	38	2	63	2	OR8K3	11	56085843	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	382900	56085843	78920673	126	16358										
OR5B17	219965	broad.mit.edu	37	chr11	58125948	58125948	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gacattaaaacttgatataaGaacaagaatcaactcactaa	4	7	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:58125948G>T	uc010rke.1	-	1	595	c.595C>A	c.(595-597)CTT>ATT	p.L199I		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTTGATATAAGAACAAGAATC	0.363													1	0	0.00909568	0.009096	0.00950768	3	37										T	58125948	G	T	58125948	3	4	56	1	0	0	0	0	1	0	0	0	11149	942	33	3	351	3	OR5B17	11	58125948	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2040105	58125948	76880568	127	16359										
SF1	7536	broad.mit.edu	37	chr11	64533611	64533631	+	Splice_Site	DEL	GGTGGTAGTCGTCGTATCTGG	GGTGGTAGTCGTCGTATCTGG	-													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaccctgtgccagcgctcgtGgtggtagtcgtcgtatctgg							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:64533611_64533631delGGTGGTAGTCGTCGTATCTGG	uc001obb.1	-	13	1960	c.1583_splice	c.e13-1	p.N528_splice	SF1_uc010rnm.1_Intron|SF1_uc010rnn.1_Splice_Site_p.N502_splice|SF1_uc001oaz.1_Intron|SF1_uc001oba.1_Splice_Site_p.N528_splice|SF1_uc001obc.1_Intron|SF1_uc001obd.1_Intron|SF1_uc001obe.1_Intron|SF1_uc010rno.1_Intron	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1						nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						CAGCGCTCGTGGTGGTAGTCGTCGTATCTGGGGTGGTAAAG	0.67																		11	62	---	---								-	64533631	GGTGGTAGTCGTCGTATCTGG	-	64533611	8	5	56	1	0	1	0	1	0	0	1	0	14145	1335	47	0	458	0	SF1	11	64533611	Splice_Site	DEL	GGTGGTAGTCGTCGTATCTGG	TCGA-DK-A3IK-01A-32D-A21A-08	6407663	64533611	70472905	128	16360										
PITPNM1	9600	broad.mit.edu	37	chr11	67267792	67267792	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgggccagcatgcgagcagtCtcctcttccagtgcccggat	12	14	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:67267792C>G	uc001olx.2	-	5	930	c.741G>C	c.(739-741)GAG>GAC	p.E247D	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.E247D|PITPNM1_uc001olz.2_Missense_Mutation_p.E247D	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	247					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGCGAGCAGTCTCCTCTTCCA	0.682													0	0	0	0.01441	0	57	260										G	67267792	C	G	67267792	3	3	56	1	0	0	0	0	1	0	0	0	11950	912	32	1	3069	1	PITPNM1	11	67267792	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2734181	67267792	67738724	129	16361										
CPT1A	1374	broad.mit.edu	37	chr11	68525172	68525172	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atgtcagtcattgcttctttCaggtgccttccaaagcgatg	9	10	4	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:68525172C>G	uc001oog.3	-	19	2432	c.2262G>C	c.(2260-2262)CTG>CTC	p.L754L	CPT1A_uc001oof.3_Intron|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	754	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TTGCTTCTTTCAGGTGCCTTC	0.398													0	0	0	0.008291	0	9	39										G	68525172	C	G	68525172	2	3	56	1	0	0	0	0	0	0	0	1	3831	813	29	1		1	CPT1A	11	68525172	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1257380	68525172	66481344	130	16362										
ATM	472	broad.mit.edu	37	chr11	108216494	108216494	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgcaaaaaaagtcttttgaaGagaaatatgaagtcttcatg	8	4	3	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:108216494G>A	uc001pkb.1	+	58	8828	c.8443G>A	c.(8443-8445)GAG>AAG	p.E2815K	ATM_uc009yxr.1_Missense_Mutation_p.E2815K|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E1467K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2815	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTCTTTTGAAGAGAAATATGA	0.269			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.009096	0	3	67										A	108216494	G	A	108216494	3	1	56	1	0	0	0	0	1	0	0	0	1109	943	33	1	8669	1	ATM	11	108216494	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	39691322	108216494	26790022	131	16363										
C11orf63	79864	broad.mit.edu	37	chr11	122756667	122756667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaagaaagaagacttacatcGgatttcaaaagactccttgg	9	7	1	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:122756667G>A	uc001pym.2	+	2	407	c.110G>A	c.(109-111)CGG>CAG	p.R37Q	C11orf63_uc001pyl.1_Missense_Mutation_p.R37Q	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	37										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GACTTACATCGGATTTCAAAA	0.433													0	0	0	0.012319	0	23	55										A	122756667	G	A	122756667	3	1	56	1	0	0	0	0	1	0	0	0	1654	1116	39	2	112	2	C11orf63	11	122756667	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	14540173	122756667	12249849	132	16364										
TMEM225	338661	broad.mit.edu	37	chr11	123753889	123753889	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtttggacttttttgtttaGggaattcacagtgtgtgcac	11	5	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:123753889G>C	uc001pzi.2	-	4	842	c.634C>G	c.(634-636)CTA>GTA	p.L212V		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	212						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						TTTTTGTTTAGGGAATTCACA	0.408													0	0	0	0.004007	0	15	72										C	123753889	G	C	123753889	3	2	56	1	0	0	0	0	1	0	0	0	16144	991	35	4	47	4	TMEM225	11	123753889	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	997222	123753889	11252627	133	16365										
ROBO4	54538	broad.mit.edu	37	chr11	124763844	124763844	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cagagtgcaacaccgcaggtGgcaatgacctcaggccgctt	12	13	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:124763844G>C	uc001qbg.2	-	9	1556	c.1416C>G	c.(1414-1416)GCC>GCG	p.A472A	ROBO4_uc010sas.1_Silent_p.A327A|ROBO4_uc001qbh.2_Silent_p.A362A|ROBO4_uc001qbi.2_Silent_p.A30A|ROBO4_uc010sat.1_Silent_p.A30A	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	472					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CACCGCAGGTGGCAATGACCT	0.652													0	0	0	0.001984	0	4	25										C	124763844	G	C	124763844	2	2	56	1	0	0	0	0	0	0	0	1	13516	1335	47	4		4	ROBO4	11	124763844	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1009955	124763844	10242672	134	16366										
KIRREL3	84623	broad.mit.edu	37	chr11	126314964	126314964	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcccgcgtcctcctggcgcaCggatttgagggtcagggtct	15	13	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:126314964C>T	uc001qea.2	-	10	1523	c.1162G>A	c.(1162-1164)GTG>ATG	p.V388M	KIRREL3_uc001qeb.2_Missense_Mutation_p.V388M|KIRREL3_uc001qec.1_Missense_Mutation_p.V388M	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	388	Extracellular (Potential).|Ig-like C2-type 4.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TCCTGGCGCACGGATTTGAGG	0.617													0	0	0	0.00499	0	15	59										T	126314964	C	T	126314964	3	4	56	1	0	0	0	0	1	0	0	0	8326	536	19	2	1313	2	KIRREL3	11	126314964	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1551120	126314964	8691552	135	16367										
ARHGAP32	9743	broad.mit.edu	37	chr11	128856559	128856559	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gacgtgctcagagtcaaattCatggctgacgtagacagaag	12	8	3	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:128856559C>T	uc009zcp.2	-	13	1261	c.1261G>A	c.(1261-1263)GAA>AAA	p.E421K	ARHGAP32_uc009zcq.1_Missense_Mutation_p.E381K|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Missense_Mutation_p.E72K|ARHGAP32_uc001qfb.2_Missense_Mutation_p.E206K	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	421	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GAGTCAAATTCATGGCTGACG	0.453													0	0	0	0.003163	0	14	49										T	128856559	C	T	128856559	3	4	56	1	0	0	0	0	1	0	0	0	881	835	29	1	5042	1	ARHGAP32	11	128856559	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2541595	128856559	6149957	136	16368										
ADAMTS15	170689	broad.mit.edu	37	chr11	130341218	130341218	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaagagattcgacaagtgtgGggtgtgtgggggagacaata	18	3	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:130341218G>C	uc010scd.1	+	7	2018	c.2018G>C	c.(2017-2019)GGG>GCG	p.G673A		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	673	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GACAAGTGTGGGGTGTGTGGG	0.567													0	0	0	0.006214	0	9	78										C	130341218	G	C	130341218	3	2	56	1	0	0	0	0	1	0	0	0	260	1232	43	4	2044	4	ADAMTS15	11	130341218	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1484659	130341218	4665298	137	16369										
IGSF9B	22997	broad.mit.edu	37	chr11	133790010	133790010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gctgagggggctttgggtcaGaggtgagagccgggagggct	22	6	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr11:133790010G>C	uc001qgx.3	-	18	3841	c.3610C>G	c.(3610-3612)CTG>GTG	p.L1204V		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1204	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTTTGGGTCAGAGGTGAGAGC	0.711													0	0	0	0.008361	0	28	93										C	133790010	G	C	133790010	3	2	56	1	0	0	0	0	1	0	0	0	7606	933	33	1	447	1	IGSF9B	11	133790010	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	3448792	133790010	1216506	138	16370										
IQSEC3	440073	broad.mit.edu	37	chr12	247681	247681	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gggctgccgctggtgcgctcGccctccctgccgcccacctt	12	20	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:247681G>A	uc001qhw.1	+	1	249	c.243G>A	c.(241-243)TCG>TCA	p.S81S	IQSEC3_uc001qhu.1_Silent_p.S81S|IQSEC3_uc001qht.1_Silent_p.S166S|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	384					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGGTGCGCTCGCCCTCCCTGC	0.697													0	0	0	0.004672	0	3	5										A	247681	G	A	247681	2	1	56	1	0	0	0	0	0	0	0	1	7819	1074	38	2		2	IQSEC3	12	247681	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		247681	133604214	139	16371										
FBXL14	144699	broad.mit.edu	37	chr12	1702939	1702939	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcggtgaggttgtagcagccGctgaggttgaggctctcgat	16	8	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:1702939G>A	uc001qjh.2	-	1	393	c.294C>T	c.(292-294)AGC>AGT	p.S98S	WNT5B_uc009zdq.2_Intron|FBXL14_uc001qji.2_Silent_p.S10S	NM_152441	NP_689654	Q8N1E6	FXL14_HUMAN	F-box and leucine-rich repeat protein 14	98						cytoplasm				ovary(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00115)			TGTAGCAGCCGCTGAGGTTGA	0.652													0	0	0	0.006122	0	14	75										A	1702939	G	A	1702939	2	1	56	1	0	0	0	0	0	0	0	1	5710	1078	38	2		2	FBXL14	12	1702939	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1455258	1702939	132148956	140	16372										
NCAPD2	9918	broad.mit.edu	37	chr12	6634839	6634839	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agaaggtcgcctgctgtcctCtggagcgctgttcctctgtc	12	13	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:6634839C>G	uc001qoo.2	+	18	2351	c.2305C>G	c.(2305-2307)CTG>GTG	p.L769V	NCAPD2_uc009zen.1_Missense_Mutation_p.L641V|NCAPD2_uc010sfd.1_Missense_Mutation_p.L724V	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	769					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						CTGCTGTCCTCTGGAGCGCTG	0.557													0	0	0	0.003163	0	13	21										G	6634839	C	G	6634839	3	3	56	1	0	0	0	0	1	0	0	0	10205	912	32	1	2371	1	NCAPD2	12	6634839	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	4931900	6634839	127217056	141	16373										
SPSB2	84727	broad.mit.edu	37	chr12	6981672	6981672	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cccccgcccgatgtcccagcCccacgactcgctgttgctgc	9	21	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:6981672C>A	uc001qrl.2	-	2	550	c.394G>T	c.(394-396)GGC>TGC	p.G132C	SPSB2_uc001qrm.2_Missense_Mutation_p.G132C|SPSB2_uc010sfp.1_Missense_Mutation_p.G132C|LRRC23_uc001qrn.1_5'Flank	NM_001146316	NP_001139788	Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box	132	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding			kidney(1)	1						ATGTCCCAGCCCCACGACTCG	0.701											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.39806e-14	0.008361	1.63197e-14	23	114										A	6981672	C	A	6981672	3	1	56	1	0	0	0	0	1	0	0	0	15112	623	22	4	405	4	SPSB2	12	6981672	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	346833	6981672	126870223	142	16374										
BHLHE41	79365	broad.mit.edu	37	chr12	26275715	26275715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtccggccgggcctcggcttCgccgccgtagccgctgtcgg	16	17	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:26275715C>T	uc001rhb.2	-	5	1024	c.733G>A	c.(733-735)GAA>AAA	p.E245K		NM_030762	NP_110389	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix domain containing, class	245					cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCTCGGCTTCGCCGCCGTAG	0.736													0	0	0	0.004482	0	7	14										T	26275715	C	T	26275715	3	4	56	1	0	0	0	0	1	0	0	0	1424	893	31	1	719	1	BHLHE41	12	26275715	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	19294043	26275715	107576180	143	16375										
FAM113B	91523	broad.mit.edu	37	chr12	47629841	47629841	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccatcaccagggaatgccccGgttcccacagggtcccccag	10	18	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:47629841G>A	uc001rpn.2	+	4	1726	c.995G>A	c.(994-996)CGG>CAG	p.R332Q	FAM113B_uc001rpq.2_Missense_Mutation_p.R332Q	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	332	Pro-rich.						hydrolase activity	p.R332W(1)		skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					GGAATGCCCCGGTTCCCACAG	0.328													0	0	0	0.01441	0	37	178										A	47629841	G	A	47629841	3	1	56	1	0	0	0	0	1	0	0	0	5402	1116	39	2	997	2	FAM113B	12	47629841	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	21354126	47629841	86222054	144	16376										
DDN	23109	broad.mit.edu	37	chr12	49391444	49391444	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	catccggtgcctccgggagcCcagggtctggggagtgtctg	17	12	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:49391444C>G	uc001rsv.1	-	2	1233	c.1215G>C	c.(1213-1215)TGG>TGC	p.W405C	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	405	Interaction with ACTN1.					dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						CTCCGGGAGCCCAGGGTCTGG	0.627													0	0	0	0.020292	0	12	50										G	49391444	C	G	49391444	3	3	56	1	0	0	0	0	1	0	0	0	4333	624	22	4	924	4	DDN	12	49391444	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1761603	49391444	84460451	145	16377										
ITGA7	3679	broad.mit.edu	37	chr12	56094913	56094913	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggatctggtccactcgctgcCttgcctcatatcggtgtgca	11	13	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:56094913C>G	uc001shh.2	-	4	660	c.440G>C	c.(439-441)AGG>ACG	p.R147T	ITGA7_uc001shg.2_Missense_Mutation_p.R147T|ITGA7_uc010sps.1_Missense_Mutation_p.R50T|ITGA7_uc009znx.2_Missense_Mutation_p.R34T	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	147	FG-GAP 2.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CACTCGCTGCCTTGCCTCATA	0.592													0	0	0	0.020292	0	11	202										G	56094913	C	G	56094913	3	3	56	1	0	0	0	0	1	0	0	0	7881	681	24	4	3197	4	ITGA7	12	56094913	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	6703469	56094913	77756982	146	16378										
HMGA2	8091	broad.mit.edu	37	chr12	66357034	66357034	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtgtgttccaggaggaaactGaagagacatcctcacaagag	12	8	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:66357034G>A	uc001ssx.2	+	5	1103	c.292G>A	c.(292-294)GAA>AAA	p.E98K		NM_003483	NP_003474	P52926	HMGA2_HUMAN	high mobility group AT-hook 2 isoform a	98					cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		GGAGGAAACTGAAGAGACATC	0.512			T	LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								0	0	0	0.003163	0	12	39										A	66357034	G	A	66357034	3	1	56	1	0	0	0	0	1	0	0	0	7224	1291	45	1	386	1	HMGA2	12	66357034	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	10262121	66357034	67494861	147	16379										
KRR1	11103	broad.mit.edu	37	chr12	75905364	75905364	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctttttctggccgctccagcGagggagacgccatttgcaag	12	12	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:75905364G>A	uc001sxt.2	-	1	55	c.14C>T	c.(13-15)TCG>TTG	p.S5L	KRR1_uc009zsc.2_Missense_Mutation_p.S5L|KRR1_uc010stx.1_Missense_Mutation_p.S5L	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	5					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						CCGCTCCAGCGAGGGAGACGC	0.532													0	0	0	0.006214	0	9	49										A	75905364	G	A	75905364	3	1	56	1	0	0	0	0	1	0	0	0	8446	1059	37	1	1171	1	KRR1	12	75905364	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9548330	75905364	57946531	148	16380										
DUSP6	1848	broad.mit.edu	37	chr12	89743323	89743341	+	Splice_Site	DEL	TTGCCCCGGGCTTCATCTG	TTGCCCCGGGCTTCATCTG	-													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtaccaagacaccacagttcTtgccccgggcttcatctgtg							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:89743323_89743341delTTGCCCCGGGCTTCATCTG	uc001tay.2	-	3	1319	c.839_splice	c.e3-1	p.D280_splice	DUSP6_uc001taz.2_Splice_Site_p.D134_splice	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a						dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						ACCACAGTTCTTGCCCCGGGCTTCATCTGTGAACACAAA	0.425																		14	59	---	---								-	89743341	TTGCCCCGGGCTTCATCTG	-	89743323	8	5	56	1	0	1	0	1	0	0	1	0	4829	1609	56	0	295	0	DUSP6	12	89743323	Splice_Site	DEL	TTGCCCCGGGCTTCATCTG	TCGA-DK-A3IK-01A-32D-A21A-08	13837959	89743323	44108572	149	16381										
GNPTAB	79158	broad.mit.edu	37	chr12	102158444	102158444	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttcatctgttattatagcttGattttttattttagcatgct	5	5	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:102158444G>A	uc001tit.2	-	13	2430	c.2251C>T	c.(2251-2253)CAA>TAA	p.Q751*		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	751					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						ATTATAGCTTGATTTTTTATT	0.383													0	0	0	0.014758	0	5	26										A	102158444	G	A	102158444	4	1	56	1	0	0	0	0	0	1	0	0	6545	1299	45	1	1555	1	GNPTAB	12	102158444	Nonsense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	12415121	102158444	31693451	150	16382										
ALDH1L2	160428	broad.mit.edu	37	chr12	105440691	105440691	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcttacccgagtggctctttCttggtgaaggtcagattgcg	12	9	4	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:105440691C>T	uc001tlc.2	-	14	1870	c.1743G>A	c.(1741-1743)AAG>AAA	p.K581K	ALDH1L2_uc009zuo.2_Silent_p.K36K|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	581	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						GTGGCTCTTTCTTGGTGAAGG	0.393													0	0	0	0.007835	0	35	159										T	105440691	C	T	105440691	2	4	56	1	0	0	0	0	0	0	0	1	495	912	32	1		1	ALDH1L2	12	105440691	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3282247	105440691	28411204	151	16383										
ANAPC7	51434	broad.mit.edu	37	chr12	110826320	110826320	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcaggaaatatctctacctaGaatggcatcaagggctaatg	10	8	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:110826320G>C	uc001tqo.2	-	4	620	c.619C>G	c.(619-621)CTA>GTA	p.L207V	ANAPC7_uc001tqp.3_Missense_Mutation_p.L207V	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	207					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						TCTCTACCTAGAATGGCATCA	0.373													0	0	0	0.006214	0	8	62										C	110826320	G	C	110826320	3	2	56	1	0	0	0	0	1	0	0	0	606	933	33	1	1216	1	ANAPC7	12	110826320	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	5385629	110826320	23025575	152	16384										
TBX5	6910	broad.mit.edu	37	chr12	114836395	114836395	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cacatgcccaaatgggtccaGgtggttgttggtgagcttga	14	8	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:114836395G>A	uc001tvo.2	-	5	988	c.493C>T	c.(493-495)CTG>TTG	p.L165L	TBX5_uc001tvp.2_Silent_p.L165L|TBX5_uc001tvq.2_Silent_p.L115L|TBX5_uc010syv.1_Silent_p.L165L	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	165	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AATGGGTCCAGGTGGTTGTTG	0.468													0	0	0	0.014758	0	5	30										A	114836395	G	A	114836395	2	1	56	1	0	0	0	0	0	0	0	1	15658	991	35	2		2	TBX5	12	114836395	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	4010075	114836395	19015500	153	16385										
TAOK3	51347	broad.mit.edu	37	chr12	118590040	118590040	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atgctcccttaccttctgctCaaggtgtgctctgcgcagag	10	13	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:118590040C>G	uc001twx.2	-	20	2822	c.2527G>C	c.(2527-2529)GAG>CAG	p.E843Q	TAOK3_uc001twv.2_Missense_Mutation_p.E383Q|TAOK3_uc001tww.2_Missense_Mutation_p.E673Q|TAOK3_uc001twy.3_Missense_Mutation_p.E843Q	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	843	Potential.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCTTCTGCTCAAGGTGTGCT	0.468													0	0	0	0.008291	0	8	67										G	118590040	C	G	118590040	3	3	56	1	0	0	0	0	1	0	0	0	15546	835	29	1	177	1	TAOK3	12	118590040	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3753645	118590040	15261855	154	16386										
TAOK3	51347	broad.mit.edu	37	chr12	118599765	118599765	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcctgtactctagctctcggGtggactcgtcgtgccggatt	13	12	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:118599765G>T	uc001twx.2	-	18	2262	c.1967C>A	c.(1966-1968)ACC>AAC	p.T656N	TAOK3_uc001twv.2_Missense_Mutation_p.T196N|TAOK3_uc001tww.2_Missense_Mutation_p.T486N|TAOK3_uc001twy.3_Missense_Mutation_p.T656N	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	656					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAGCTCTCGGGTGGACTCGTC	0.512													1	0	2.4624e-09	0.008871	2.80882e-09	16	62										T	118599765	G	T	118599765	3	4	56	1	0	0	0	0	1	0	0	0	15546	1261	44	4	745	4	TAOK3	12	118599765	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9725	118599765	15252130	155	16387										
GCN1L1	10985	broad.mit.edu	37	chr12	120597747	120597747	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aaagagtcgaccaaaacaggGatgtactgggtcaggccgga	14	8	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:120597747G>C	uc001txo.2	-	24	2644	c.2631C>G	c.(2629-2631)ATC>ATG	p.I877M		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	877					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAAAACAGGGATGTACTGGG	0.592													0	0	0	0.004007	0	14	88										C	120597747	G	C	120597747	3	2	56	1	0	0	0	0	1	0	0	0	6299	1164	41	1	5524	1	GCN1L1	12	120597747	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1997982	120597747	13254148	156	16388										
CCDC62	84660	broad.mit.edu	37	chr12	123297940	123297940	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cactgctgcccatcagccatGagaatctcactggcagtgcc	9	15	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:123297940G>A	uc001udc.2	+	11	2120	c.1975G>A	c.(1975-1977)GAG>AAG	p.E659K	CCDC62_uc010tah.1_RNA|CCDC62_uc001udf.2_Missense_Mutation_p.E659K|CCDC62_uc001ude.2_Missense_Mutation_p.E420K	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	659						cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CATCAGCCATGAGAATCTCAC	0.498													0	0	0	0.006214	0	10	59										A	123297940	G	A	123297940	3	1	56	1	0	0	0	0	1	0	0	0	2833	1291	45	1	2017	1	CCDC62	12	123297940	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2700193	123297940	10553955	157	16389										
POLE	5426	broad.mit.edu	37	chr12	133218913	133218913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gttgtggcgctggaggtggcGggcaaagaagaggtcggagc	21	6	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr12:133218913G>A	uc001uks.1	-	38	5067	c.5023C>T	c.(5023-5025)CGC>TGC	p.R1675C	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.R479C|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1675					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TGGAGGTGGCGGGCAAAGAAG	0.597								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.004656	0	26	45										A	133218913	G	A	133218913	3	1	56	1	0	0	0	0	1	0	0	0	12196	1116	39	2	1885	2	POLE	12	133218913	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9920973	133218913	632982	158	16390										
FNDC3A	22862	broad.mit.edu	37	chr13	49760119	49760119	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggttattgcttacaactcagAaggtaaaagtaatccaagtg	9	6	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr13:49760119A>C	uc001vcm.2	+	15	1942	c.1637A>C	c.(1636-1638)GAA>GCA	p.E546A	FNDC3A_uc001vcn.2_Missense_Mutation_p.E546A|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.E472A|FNDC3A_uc001vcq.2_Missense_Mutation_p.E490A	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	546	Fibronectin type-III 3.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACAACTCAGAAGGTAAAAGT	0.353													0	0	0	0.001984	0	7	22										C	49760119	A	C	49760119	3	2	56	1	0	0	0	0	1	0	0	0	5969	246	9	5	1702	5	FNDC3A	13	49760119	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08		49760119	65409759	159	16391										
GAS6	2621	broad.mit.edu	37	chr13	114530137	114530137	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gccatccagacgagggtttaTctggaaaggcagagaaatct	12	8	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr13:114530137T>C	uc001vud.2	-	12	1462	c.1309A>G	c.(1309-1311)ATA>GTA	p.I437V	GAS6_uc001vug.2_Missense_Mutation_p.I138V|GAS6_uc001vuf.2_Missense_Mutation_p.I164V	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	480	Laminin G-like 1.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				CGAGGGTTTATCTGGAAAGGC	0.592													0	0	0	0.010818	0	27	79										C	114530137	T	C	114530137	3	2	56	1	0	0	0	0	1	0	0	0	6249	1449	50	5	743	5	GAS6	13	114530137	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	64770018	114530137	639741	160	16392										
DCAF11	80344	broad.mit.edu	37	chr14	24584853	24584853	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atccgggtccggagacccctCcgagggcttgccccgaagag	14	15	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:24584853C>G	uc001wlv.2	+	2	330	c.50C>G	c.(49-51)TCC>TGC	p.S17C	NRL_uc001wlq.2_5'Flank|DCAF11_uc001wlw.2_Missense_Mutation_p.S17C|DCAF11_uc001wlz.2_5'UTR|DCAF11_uc001wly.2_5'UTR|DCAF11_uc001wme.2_Missense_Mutation_p.S17C|DCAF11_uc010tny.1_5'UTR|DCAF11_uc001wmd.2_Missense_Mutation_p.S17C|DCAF11_uc001wmc.2_5'UTR|DCAF11_uc001wmb.3_Missense_Mutation_p.S17C|DCAF11_uc001wma.3_Missense_Mutation_p.S17C	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	17						CUL4 RING ubiquitin ligase complex	protein binding				0						GGAGACCCCTCCGAGGGCTTG	0.617													0	0	0	0.01441	0	34	70										G	24584853	C	G	24584853	3	3	56	1	0	0	0	0	1	0	0	0	4262	855	30	1	52	1	DCAF11	14	24584853	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		24584853	82764687	161	16393										
G2E3	55632	broad.mit.edu	37	chr14	31085657	31085657	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccatcaccaatacatataaaGagtttcaagaaaatatggac	5	8	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:31085657G>C	uc001wqk.2	+	15	2192	c.2038G>C	c.(2038-2040)GAG>CAG	p.E680Q	G2E3_uc010tpf.1_Missense_Mutation_p.E634Q|G2E3_uc001wql.1_Missense_Mutation_p.E192Q	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	680	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TACATATAAAGAGTTTCAAGA	0.333													0	0	0	0.006214	0	8	19										C	31085657	G	C	31085657	3	2	56	1	0	0	0	0	1	0	0	0	6140	943	33	1	2092	1	G2E3	14	31085657	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	6500804	31085657	76263883	162	16394										
LRFN5	145581	broad.mit.edu	37	chr14	42361055	42361055	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaatgaagccgtcacaaatgTtgaatcccaaaacactaaca	6	10	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:42361055T>C	uc001wvm.2	+	4	3186	c.1988T>C	c.(1987-1989)GTT>GCT	p.V663A	LRFN5_uc010ana.2_Intron	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	663	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTCACAAATGTTGAATCCCAA	0.483										HNSCC(30;0.082)			0	0	0	0.013537	0	11	28										C	42361055	T	C	42361055	3	2	56	1	0	0	0	0	1	0	0	0	8941	1725	60	5	1994	5	LRFN5	14	42361055	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	11275398	42361055	64988485	163	16395										
SPATA7	55812	broad.mit.edu	37	chr14	88892876	88892876	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cgaaagcacccagtggggatCttttggataaacattctgaa	10	8	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:88892876C>G	uc001xwq.2	+	6	824	c.673C>G	c.(673-675)CTT>GTT	p.L225V	SPATA7_uc001xwr.2_Missense_Mutation_p.L193V|SPATA7_uc001xws.2_Missense_Mutation_p.L161V|SPATA7_uc001xwt.2_Missense_Mutation_p.L119V|SPATA7_uc001xwu.2_5'Flank	NM_018418	NP_060888	Q9P0W8	SPAT7_HUMAN	spermatogenesis-associated protein 7 isoform a	225					response to stimulus|visual perception					ovary(1)	1						CAGTGGGGATCTTTTGGATAA	0.438													0	0	0	0.010504	0	16	75										G	88892876	C	G	88892876	3	3	56	1	0	0	0	0	1	0	0	0	15013	913	32	1	695	1	SPATA7	14	88892876	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	46531821	88892876	18456664	164	16396										
BTBD7	55727	broad.mit.edu	37	chr14	93712182	93712182	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttgacttaccacttgcttctCagatgctgctgctgctgctg	9	12	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:93712182C>T	uc001ybo.2	-	10	2898	c.2572G>A	c.(2572-2574)GAG>AAG	p.E858K	BTBD7_uc010aur.2_Missense_Mutation_p.E383K|BTBD7_uc010two.1_Missense_Mutation_p.E678K|BTBD7_uc001ybp.2_Missense_Mutation_p.E507K	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	858										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTTGCTTCTCAGAtgctgct	0.448													0	0	0	0.016723	0	14	43										T	93712182	C	T	93712182	3	4	56	1	0	0	0	0	1	0	0	0	1546	835	29	1	834	1	BTBD7	14	93712182	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	4819306	93712182	13637358	165	16397										
ATG2B	55102	broad.mit.edu	37	chr14	96784135	96784135	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atgccataggaaatattctcGaatgtctccactggtgaagg	10	8	2	1	rs113424169		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:96784135G>C	uc001yfi.2	-	19	3302	c.2937C>G	c.(2935-2937)TTC>TTG	p.F979L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	979										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AAATATTCTCGAATGTCTCCA	0.368													0	0	0	0.00623	0	32	83										C	96784135	G	C	96784135	3	2	56	1	0	0	0	0	1	0	0	0	1094	1049	37	1	3395	1	ATG2B	14	96784135	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	3071953	96784135	10565405	166	16398										
AHNAK2	113146	broad.mit.edu	37	chr14	105413989	105413989	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	catcgggggctgtcacttccGccttggggcctttcaggtcc	13	14	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr14:105413989G>A	uc010axc.1	-	7	7919	c.7799C>T	c.(7798-7800)GCG>GTG	p.A2600V	AHNAK2_uc001ypx.2_Missense_Mutation_p.A2500V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2600						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTCACTTCCGCCTTGGGGCC	0.622													0	0	0	0.01441	0	41	217										A	105413989	G	A	105413989	3	1	56	1	0	0	0	0	1	0	0	0	415	1087	38	2	9592	2	AHNAK2	14	105413989	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	8629854	105413989	1935551	167	16399										
C15orf55	256646	broad.mit.edu	37	chr15	34646669	34646669	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tacattccgaagaaggcagcCtccaagacacgggccccccg	10	16	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:34646669C>G	uc001zif.2	+	5	1169	c.1014C>G	c.(1012-1014)GCC>GCG	p.A338A	C15orf55_uc010ucc.1_Silent_p.A366A|C15orf55_uc010ucd.1_Silent_p.A356A	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	338						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGAAGGCAGCCTCCAAGACAC	0.557			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.012319	0	19	92										G	34646669	C	G	34646669	2	3	56	1	0	0	0	0	0	0	0	1	1803	668	24	4		4	C15orf55	15	34646669	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		34646669	67884723	168	16400										
PPIB	5479	broad.mit.edu	37	chr15	64454323	64454323	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aaagatcacccggcctacatCttcatctccaattcgtaggt	6	13	4	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:64454323C>A	uc002and.2	-	2	335	c.166G>T	c.(166-168)GAT>TAT	p.D56Y	PPIB_uc010bgx.1_Missense_Mutation_p.D48Y	NM_000942	NP_000933	P23284	PPIB_HUMAN	peptidylprolyl isomerase B precursor	56	PPIase cyclophilin-type.				protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding				0					L-Proline(DB00172)	CGGCCTACATCTTCATCTCCA	0.463													1	0	1.67211e-32	0.01441	1.99061e-32	44	157										A	64454323	C	A	64454323	3	1	56	1	0	0	0	0	1	0	0	0	12319	913	32	3	500	3	PPIB	15	64454323	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	29807654	64454323	38077069	169	16401										
ISG20	3669	broad.mit.edu	37	chr15	89182733	89182733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acgacaagttcatccggcctGagggagagatcaccgattac	11	11	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:89182733G>C	uc002bmv.1	+	2	429	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	ISG20_uc002bmu.1_Intron|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	46					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			CATCCGGCCTGAGGGAGAGAT	0.642													0	0	0	0.007413	0	15	117										C	89182733	G	C	89182733	3	2	56	1	0	0	0	0	1	0	0	0	7854	1291	45	1	138	1	ISG20	15	89182733	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	24728410	89182733	13348659	170	16402										
HDDC3	374659	broad.mit.edu	37	chr15	91475081	91475081	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agtcttgtcatctgttacctCctccaccaggcgccgcactt	7	16	3	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr15:91475081C>A	uc002bqf.3	-	3	266	c.262G>T	c.(262-264)GAG>TAG	p.E88*	UNC45A_uc002bqd.2_Intron|HDDC3_uc002bqe.3_Nonsense_Mutation_p.E88*	NM_198527	NP_940929	Q8N4P3	MESH1_HUMAN	HD domain containing 3	88	HD.						guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity|metal ion binding|phosphoric diester hydrolase activity			ovary(1)	1	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TCTGTTACCTCCTCCACCAGG	0.627											OREG0023475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.05317e-09	0.020292	1.21054e-09	13	75										A	91475081	C	A	91475081	4	1	56	1	0	0	0	0	0	1	0	0	7017	864	30	3	168	3	HDDC3	15	91475081	Nonsense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2292348	91475081	11056311	171	16403										
WDR90	197335	broad.mit.edu	37	chr16	716521	716521	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtggggaccagcgggtcagcGtctgggcctccgactggctg	18	12	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:716521G>T	uc002cii.1	+	38	4861	c.4807G>T	c.(4807-4809)GTC>TTC	p.V1603F	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Missense_Mutation_p.V218F|WDR90_uc010uul.1_Intron|WDR90_uc002cio.1_Missense_Mutation_p.V202F|WDR90_uc010bqx.1_Intron|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1603	WD 20.									ovary(1)	1		Hepatocellular(780;0.0218)				GCGGGTCAGCGTCTGGGCCTC	0.622													1	0	7.45023e-12	0.010504	8.66305e-12	18	51										T	716521	G	T	716521	3	4	56	1	0	0	0	0	1	0	0	0	17334	1145	40	4	4957	4	WDR90	16	716521	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		716521	89638232	172	16404										
MKL2	57496	broad.mit.edu	37	chr16	14345773	14345773	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttccatatcagagacatcctGccccagctgtccagcagccc	7	17	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:14345773G>A	uc010uza.1	+	14	2613	c.2458G>A	c.(2458-2460)GCC>ACC	p.A820T	MKL2_uc002dcg.2_Missense_Mutation_p.A770T|MKL2_uc002dcj.2_Missense_Mutation_p.A65T	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	809					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						GAGACATCCTGCCCCAGCTGT	0.423													0	0	0	0.009535	0	26	115										A	14345773	G	A	14345773	3	1	56	1	0	0	0	0	1	0	0	0	9602	1319	46	2	2354	2	MKL2	16	14345773	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	13629252	14345773	76008980	173	16405										
ATP2A1	487	broad.mit.edu	37	chr16	28914646	28914646	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcttgtcccctgccccagatGatcttcaagctccgggccct	9	17	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:28914646G>A	uc002dro.1	+	21	3049	c.2865G>A	c.(2863-2865)ATG>ATA	p.M955I	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.M955I|ATP2A1_uc002drp.1_Missense_Mutation_p.M830I	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	955	Lumenal (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGCCCCAGATGATCTTCAAGC	0.637													0	0	0	0.008871	0	17	259										A	28914646	G	A	28914646	3	1	56	1	0	0	0	0	1	0	0	0	1136	1290	45	1	2947	1	ATP2A1	16	28914646	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	14568873	28914646	61440107	174	16406										
QPRT	23475	broad.mit.edu	37	chr16	29708422	29708422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctgaggctggtgccgaccttGtcctgctggacaacttcaag	12	12	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:29708422G>A	uc002dto.2	+	3	733	c.655G>A	c.(655-657)GTC>ATC	p.V219I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|QPRT_uc010vdu.1_RNA	NM_014298	NP_055113	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	219					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity				0					Niacin(DB00627)	TGCCGACCTTGTCCTGCTGGA	0.642													0	0	0	0.00308	0	6	47										A	29708422	G	A	29708422	3	1	56	1	0	0	0	0	1	0	0	0	12876	1377	48	2	665	2	QPRT	16	29708422	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	793776	29708422	60646331	175	16407										
MVP	9961	broad.mit.edu	37	chr16	29855914	29855914	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcaaagccatcgcatcccggGtgcggggggccgtggcctct	16	14	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:29855914G>T	uc002dui.2	+	11	1819	c.1735G>T	c.(1735-1737)GTG>TTG	p.V579L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc002duj.2_Missense_Mutation_p.V579L|MVP_uc010vea.1_Missense_Mutation_p.V173L	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	579					mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CGCATCCCGGGTGCGGGGGGC	0.562													1	0	3.65916e-55	0.01441	4.40863e-55	157	101										T	29855914	G	T	29855914	3	4	56	1	0	0	0	0	1	0	0	0	9996	1261	44	4	1773	4	MVP	16	29855914	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	147492	29855914	60498839	176	16408										
SETD1A	9739	broad.mit.edu	37	chr16	30992428	30992428	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccggagccggatccacgagtGgggtctgtttgccatggaac	15	11	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:30992428G>T	uc002ead.1	+	17	5425	c.4739G>T	c.(4738-4740)TGG>TTG	p.W1580L		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1580	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						ATCCACGAGTGGGGTCTGTTT	0.612													1	0	5.04308e-16	0.00623	5.93303e-16	35	227										T	30992428	G	T	30992428	3	4	56	1	0	0	0	0	1	0	0	0	14130	1357	47	4	4801	4	SETD1A	16	30992428	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1136514	30992428	59362325	177	16409										
CDH15	1013	broad.mit.edu	37	chr16	89260217	89260217	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cagcgctgagcctgcctctgGgaccgccgccacttcgcaga	12	17	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:89260217G>C	uc002fmt.2	+	13	2124	c.2047G>C	c.(2047-2049)GGA>CGA	p.G683R		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	683	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		CCTGCCTCTGGGACCGCCGCC	0.697													0	0	0	0.001168	0	5	40										C	89260217	G	C	89260217	3	2	56	1	0	0	0	0	1	0	0	0	3100	1233	43	4	2097	4	CDH15	16	89260217	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	58267789	89260217	1094536	178	16410										
TUBB3	10381	broad.mit.edu	37	chr16	90001364	90001364	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcatcatgaacaccttcagcGtcgtgccctcacccaaggtg	9	15	3	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr16:90001364G>A	uc002fph.1	+	4	570	c.505G>A	c.(505-507)GTC>ATC	p.V169I	TUBB3_uc002fpf.2_Missense_Mutation_p.V516I|TUBB3_uc010ciz.1_Missense_Mutation_p.V97I|TUBB3_uc002fpg.1_Missense_Mutation_p.V23I|TUBB3_uc002fpi.1_Missense_Mutation_p.V97I|TUBB3_uc002fpj.1_Missense_Mutation_p.V97I|TUBB3_uc010cjb.1_Missense_Mutation_p.V23I|TUBB3_uc002fpk.1_Missense_Mutation_p.V23I	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	169					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CACCTTCAGCGTCGTGCCCTC	0.627													0	0	0	0.01441	0	53	187										A	90001364	G	A	90001364	3	1	56	1	0	0	0	0	1	0	0	0	16754	1145	40	2	519	2	TUBB3	16	90001364	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	741147	90001364	353389	179	16411										
PELP1	27043	broad.mit.edu	37	chr17	4578480	4578480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gatcccaaagcgcaagagccGgcttccacacctggggcaga	12	14	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:4578480G>A	uc002fyi.3	-	11	1394	c.1168C>T	c.(1168-1170)CGG>TGG	p.R390W	PELP1_uc010vsf.1_Missense_Mutation_p.R243W	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	390					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						CGCAAGAGCCGGCTTCCACAC	0.612													0	0	0	0.004672	0	3	20										A	4578480	G	A	4578480	3	1	56	1	0	0	0	0	1	0	0	0	11725	1115	39	2	2252	2	PELP1	17	4578480	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		4578480	76616730	180	16412										
CXCL16	58191	broad.mit.edu	37	chr17	4642109	4642109	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agacaccgatggtaagctctCaggtgtttccggagacgatt	12	9	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:4642109C>G	uc002fyr.3	-	2	775	c.243G>C	c.(241-243)CTG>CTC	p.L81L	CXCL16_uc002fyq.3_5'Flank|CXCL16_uc002fys.3_Silent_p.L81L|ZMYND15_uc002fyv.2_5'Flank|ZMYND15_uc002fyt.2_5'Flank|ZMYND15_uc002fyu.2_5'Flank	NM_022059	NP_071342	Q9H2A7	CXL16_HUMAN	chemokine (C-X-C motif) ligand 16	62	Extracellular (Potential).|Chemokine.				lymphocyte chemotaxis|positive regulation of cell growth|positive regulation of cell migration|receptor-mediated endocytosis|response to interferon-gamma|response to tumor necrosis factor	extracellular space|integral to membrane|plasma membrane	chemokine activity|low-density lipoprotein receptor activity|scavenger receptor activity				0						GGTAAGCTCTCAGGTGTTTCC	0.552													0	0	0	0.00499	0	12	43										G	4642109	C	G	4642109	2	3	56	1	0	0	0	0	0	0	0	1	4083	813	29	1		1	CXCL16	17	4642109	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	63629	4642109	76553101	181	16413										
ASGR1	432	broad.mit.edu	37	chr17	7077715	7077715	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttgccctggagcgccgccatCtgacagctcaggctccgcag	12	16	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:7077715C>G	uc002ges.3	-	6	830	c.420G>C	c.(418-420)CAG>CAC	p.Q140H	ASGR1_uc010clx.1_Missense_Mutation_p.Q39H	NM_001671	NP_001662	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	140	Extracellular (Probable).				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)	2						GCGCCGCCATCTGACAGCTCA	0.682													0	0	0	0.004007	0	16	20										G	7077715	C	G	7077715	3	3	56	1	0	0	0	0	1	0	0	0	1039	912	32	1	471	1	ASGR1	17	7077715	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2435606	7077715	74117495	182	16414										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	52	40										T	7577538	C	T	7577538	3	4	56	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	499823	7577538	73617672	183	16415										
DNAH2	146754	broad.mit.edu	37	chr17	7702490	7702490	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	catcggacagcctcttcgccTacctcattgaacgcgtgcag	9	15	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:7702490T>C	uc002giu.1	+	55	8643	c.8629T>C	c.(8629-8631)TAC>CAC	p.Y2877H		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2877	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTCTTCGCCTACCTCATTGA	0.592													0	0	0	0.004672	0	3	68										C	7702490	T	C	7702490	3	2	56	1	0	0	0	0	1	0	0	0	4602	1522	53	5	8847	5	DNAH2	17	7702490	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	124952	7702490	73492720	184	16416										
MYH10	4628	broad.mit.edu	37	chr17	8397110	8397110	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cctggcctcctcctcctcctCctgctgctcctgaagactgt	7	19	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:8397110C>G	uc002gll.2	-	30	4153	c.4057G>C	c.(4057-4059)GAG>CAG	p.E1353Q	MYH10_uc002glm.2_Missense_Mutation_p.E1384Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1362Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1353	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCCTCCTCCTCCTGCTGCTCC	0.587													0	0	0	0.009096	0	3	49										G	8397110	C	G	8397110	3	3	56	1	0	0	0	0	1	0	0	0	10030	864	30	1	1921	1	MYH10	17	8397110	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	694620	8397110	72798100	185	16417										
MYH3	4621	broad.mit.edu	37	chr17	10538231	10538231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttcaacatcaaccatcagatCctccacctctccttgcagcc	3	18	4	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:10538231C>T	uc002gmq.1	-	30	4359	c.4282G>A	c.(4282-4284)GAT>AAT	p.D1428N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1428	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						ACCATCAGATCCTCCACCTCT	0.537													0	0	0	0.01441	0	53	36										T	10538231	C	T	10538231	3	4	56	1	0	0	0	0	1	0	0	0	10036	855	30	1	1584	1	MYH3	17	10538231	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2141121	10538231	70656979	186	16418										
UTP6	55813	broad.mit.edu	37	chr17	30205295	30205295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cttgtattggcattctgacaGaagcttcagttcatgtgcct	9	9	3	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:30205295G>C	uc002hgr.2	-	13	1182	c.1099C>G	c.(1099-1101)CTG>GTG	p.L367V	UTP6_uc002hgq.2_Missense_Mutation_p.L183V|UTP6_uc010cst.2_Missense_Mutation_p.L216V	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	367					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				CATTCTGACAGAAGCTTCAGT	0.408													0	0	0	0.01892	0	17	77										C	30205295	G	C	30205295	3	2	56	1	0	0	0	0	1	0	0	0	17099	933	33	1	722	1	UTP6	17	30205295	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	19667064	30205295	50989915	187	16419										
UTP18	51096	broad.mit.edu	37	chr17	49340655	49340655	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gttcaagaacatgaagactcGggtgactcagaagtggagaa	13	6	2	6			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:49340655G>C	uc002its.2	+	2	412	c.363G>C	c.(361-363)TCG>TCC	p.S121S		NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	121					rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			ATGAAGACTCGGGTGACTCAG	0.438													0	0	0	0.010729	0	10	46										C	49340655	G	C	49340655	2	2	56	1	0	0	0	0	0	0	0	1	17095	1103	39	4		4	UTP18	17	49340655	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	19135360	49340655	31854555	188	16420										
ANKFN1	162282	broad.mit.edu	37	chr17	54431282	54431282	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cctcctgtatcagtacacacCagaagaacttgacctcaaca	5	14	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:54431282C>G	uc002iun.1	+	5	520	c.485C>G	c.(484-486)CCA>CGA	p.P162R		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	162	ANK 1.									large_intestine(1)|ovary(1)	2						CAGTACACACCAGAAGAACTT	0.493													0	0	0	0.008871	0	17	58										G	54431282	C	G	54431282	3	3	56	1	0	0	0	0	1	0	0	0	625	594	21	4	503	4	ANKFN1	17	54431282	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	5090627	54431282	26763928	189	16421										
KIAA0195	9772	broad.mit.edu	37	chr17	73486837	73486837	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atacggaggctgtctcctctCaggtacaacactgacccggg	11	13	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:73486837C>T	uc002jnz.3	+	11	1401	c.1126C>T	c.(1126-1128)CAG>TAG	p.Q376*	KIAA0195_uc010wsa.1_Nonsense_Mutation_p.Q386*|KIAA0195_uc010wsb.1_Nonsense_Mutation_p.Q28*	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	376					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGTCTCCTCTCAGGTACAACA	0.557													0	0	0	0.016723	0	12	44										T	73486837	C	T	73486837	4	4	56	1	0	0	0	0	0	1	0	0	8160	827	29	1	1164	1	KIAA0195	17	73486837	Nonsense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	19055555	73486837	7708373	190	16422										
ARL16	339231	broad.mit.edu	37	chr17	79650829	79650829	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cgtagctcggcgccgcggctCaaggcccgcccaccggccac	13	20	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:79650829C>G	uc002kbf.2	-	1	126	c.27G>C	c.(25-27)TTG>TTC	p.L9F	ARL16_uc002kbe.2_5'Flank|HGS_uc010wus.1_5'Flank|HGS_uc002kbg.2_5'Flank	NM_001040025	NP_001035114	Q0P5N6	ARL16_HUMAN	ADP-ribosylation factor-like 16	9							GTP binding				0	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CGCCGCGGCTCAAGGCCCGCC	0.637													0	0	0	0.009096	0	4	28										G	79650829	C	G	79650829	3	3	56	1	0	0	0	0	1	0	0	0	932	825	29	1	586	1	ARL16	17	79650829	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	6163992	79650829	1544381	191	16423										
ZNF750	79755	broad.mit.edu	37	chr17	80789199	80789199	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agcctcaggaattggactttCgaactcgacgtgttttctgt	10	9	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:80789199C>T	uc002kga.2	-	2	1443	c.1132G>A	c.(1132-1134)GAA>AAA	p.E378K	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	378						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			ATTGGACTTTCGAACTCGACG	0.572													0	0	0	0.005443	0	22	108										T	80789199	C	T	80789199	3	4	56	1	0	0	0	0	1	0	0	0	18129	893	31	1	1047	1	ZNF750	17	80789199	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1138370	80789199	406011	192	16424										
TBCD	6904	broad.mit.edu	37	chr17	80887006	80887006	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cagctgtgagcgcatcatgtGctgtgtggcccagcaggcca	14	12	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr17:80887006G>T	uc002kfz.2	+	31	2841	c.2711G>T	c.(2710-2712)TGC>TTC	p.C904F	TBCD_uc002kfy.1_Missense_Mutation_p.C904F|TBCD_uc002kgb.1_Missense_Mutation_p.C229F|TBCD_uc002kgc.2_Missense_Mutation_p.C49F|TBCD_uc002kgd.2_5'Flank	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	904					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			CGCATCATGTGCTGTGTGGCC	0.612													1	0	0.00448238	0.004482	0.0047183	7	71										T	80887006	G	T	80887006	3	4	56	1	0	0	0	0	1	0	0	0	15630	1319	46	4	2833	4	TBCD	17	80887006	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	97807	80887006	308204	193	16425										
LAMA3	3909	broad.mit.edu	37	chr18	21519274	21519274	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttcccaagacccaggccaatCatggagccctccagtttggg	10	14	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr18:21519274C>T	uc002kuq.2	+	68	9036	c.8950C>T	c.(8950-8952)CAT>TAT	p.H2984Y	LAMA3_uc002kur.2_Missense_Mutation_p.H2928Y|LAMA3_uc002kus.3_Missense_Mutation_p.H1375Y|LAMA3_uc002kut.3_Missense_Mutation_p.H1319Y	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2984					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAGGCCAATCATGGAGCCCT	0.547													0	0	0	0.01441	0	75	196										T	21519274	C	T	21519274	3	4	56	1	0	0	0	0	1	0	0	0	8607	826	29	1	9395	1	LAMA3	18	21519274	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		21519274	56557974	194	16426										
RNF126	55658	broad.mit.edu	37	chr19	648951	648951	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tttatctgccggtggggggcCtgtgttttcaaactgattga	13	7	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:648951C>A	uc010drs.2	-	7	707	c.601G>T	c.(601-603)GGC>TGC	p.G201C	RNF126_uc002lpi.2_Missense_Mutation_p.G25C	NM_194460	NP_919442	Q9BV68	RN126_HUMAN	ring finger protein 126	201							protein binding|zinc ion binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGGGGGGCCTGTGTTTTCA	0.552													1	0	0.000602214	0.014758	0.000642934	4	13										A	648951	C	A	648951	3	1	56	1	0	0	0	0	1	0	0	0	13435	681	24	4	346	4	RNF126	19	648951	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		648951	58480032	195	16427										
PCSK4	54760	broad.mit.edu	37	chr19	1489889	1489889	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggtgaaagtactgcccgtcaGggaagatctggggatgtggg	18	6	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:1489889G>C	uc002ltb.1	-	2	259	c.197C>G	c.(196-198)CCT>CGT	p.P66R	PCSK4_uc002lta.2_5'UTR|REEP6_uc010xgp.1_5'Flank|REEP6_uc002ltc.2_5'Flank	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	66				P -> S (in Ref. 1; AAQ89322 and 3; AAH36354).	proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCCCGTCAGGGAAGATCTG	0.672													0	0	0	0.014758	0	3	14										C	1489889	G	C	1489889	3	2	56	1	0	0	0	0	1	0	0	0	11602	1000	35	4	2126	4	PCSK4	19	1489889	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	840938	1489889	57639094	196	16428										
MBD3	53615	broad.mit.edu	37	chr19	1584563	1584563	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cgcggctggtccaccgccttCtgcgggtcgctcttgacctt	12	16	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:1584563C>T	uc002ltl.1	-	3	406	c.384G>A	c.(382-384)CAG>CAA	p.Q128Q	MBD3_uc002ltj.2_Silent_p.Q128Q|MBD3_uc002ltk.2_Silent_p.Q96Q	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	128					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCGCCTTCTGCGGGTCGC	0.632													0	0	0	0.004656	0	25	89										T	1584563	C	T	1584563	2	4	56	1	0	0	0	0	0	0	0	1	9344	912	32	1		1	MBD3	19	1584563	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	94674	1584563	57544420	197	16429										
SH3GL1	6455	broad.mit.edu	37	chr19	4363777	4363777	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tccttggactcctcgaacttCtccagcgcctggcgtagctc	9	16	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:4363777C>G	uc002maj.2	-	6	670	c.564G>C	c.(562-564)GAG>GAC	p.E188D	SH3GL1_uc002mak.2_Missense_Mutation_p.E124D|SH3GL1_uc010xig.1_Missense_Mutation_p.E140D	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	188	Potential.|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		CCTCGAACTTCTCCAGCGCCT	0.582			T	MLL	AL								0	0	0	0.012319	0	20	85										G	4363777	C	G	4363777	3	3	56	1	0	0	0	0	1	0	0	0	14250	912	32	1	562	1	SH3GL1	19	4363777	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2779214	4363777	54765206	198	16430										
NRTN	4902	broad.mit.edu	37	chr19	5824095	5824095	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	caaaggccccacactgagtcCtggcccagcgccctgtgccc	10	19	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:5824095C>A	uc002mde.2	+	1	278	c.-81C>A	c.(-83--79)TCCTG>TCATG			NM_004558	NP_004549	Q99748	NRTN_HUMAN	neurturin preproprotein						axon guidance|MAPKKK cascade|neural crest cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region	growth factor activity				0						ACACTGAGTCCTGGCCCAGCG	0.632													1	0	0.000602214	0.014758	0.000642934	5	27										A	5824095	C	A	5824095	1	1	56	1	0	0	0	0	0	0	0	0	10664	696	24	4		4	NRTN	19	5824095	Translation_Start_Site	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1460318	5824095	53304888	199	16431										
MLLT1	4298	broad.mit.edu	37	chr19	6230661	6230661	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ctcgcagcgcaggtggttcaCgggcgggttgccttccaggt	16	12	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:6230661C>A	uc002mek.2	-	4	504	c.340G>T	c.(340-342)GTG>TTG	p.V114L		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	114					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						AGGTGGTTCACGGGCGGGTTG	0.612			T	MLL	AL								1	0	2.17066e-49	0.01441	2.60479e-49	97	162										A	6230661	C	A	6230661	3	1	56	1	0	0	0	0	1	0	0	0	9625	536	19	4	1375	4	MLLT1	19	6230661	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	406566	6230661	52898322	200	16432										
CNN1	1264	broad.mit.edu	37	chr19	11660204	11660204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcacccggcgccacctctacGaccccaagctgggcacagac	10	19	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:11660204G>A	uc002msc.1	+	6	732	c.568G>A	c.(568-570)GAC>AAC	p.D190N	CNN1_uc010xmb.1_Missense_Mutation_p.D140N|CNN1_uc010xmc.1_Missense_Mutation_p.D140N	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	190					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						CCACCTCTACGACCCCAAGCT	0.617													0	0	0	0.007413	0	16	77										A	11660204	G	A	11660204	3	1	56	1	0	0	0	0	1	0	0	0	3609	1058	37	1	590	1	CNN1	19	11660204	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	5429543	11660204	47468779	201	16433										
COMP	1311	broad.mit.edu	37	chr19	18902016	18902016	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttacccaacgggctctggccCtgtccggacgcgccgagggc	14	16	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:18902016C>A	uc002nke.2	-	1	99	c.63G>T	c.(61-63)CAG>CAT	p.Q21H	COMP_uc002nkd.2_Translation_Start_Site|COMP_uc010xqj.1_Missense_Mutation_p.Q21H	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	21					anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						GGCTCTGGCCCTGTCCGGACG	0.697													1	0	7.48243e-07	0.006214	8.28313e-07	9	8										A	18902016	C	A	18902016	3	1	56	1	0	0	0	0	1	0	0	0	3724	680	24	4	2286	4	COMP	19	18902016	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	7241812	18902016	40226967	202	16434										
ZNF737	100129842	broad.mit.edu	37	chr19	20728275	20728275	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tatgaattatcttatgtgcaGtaaggtatgaaaaccggcta	9	5	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:20728275G>A	uc002npa.2	-	4	914	c.734C>T	c.(733-735)ACT>ATT	p.T245I		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	245					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CTTATGTGCAGTAAGGTATGA	0.403													0	0	0	0.004672	0	3	26										A	20728275	G	A	20728275	3	1	56	1	0	0	0	0	1	0	0	0	18123	1029	36	2	880	2	ZNF737	19	20728275	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1826259	20728275	38400708	203	16435										
ZNF626	199777	broad.mit.edu	37	chr19	20828521	20828521	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gctatcatctcatttctcttCatggtcaaaggttttcttcc	5	11	6	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:20828521C>A	uc002npb.1	-	3	345	c.195G>T	c.(193-195)ATG>ATT	p.M65I	ZNF626_uc002npc.1_Intron|ZNF626_uc002npd.1_Missense_Mutation_p.M65I	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CATTTCTCTTCATGGTCAAAG	0.388													1	0	0.00024832	0.009096	0.000267011	4	45										A	20828521	C	A	20828521	3	1	56	1	0	0	0	0	1	0	0	0	18047	826	29	3	1456	3	ZNF626	19	20828521	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	100246	20828521	38300462	204	16436										
ZNF626	199777	broad.mit.edu	37	chr19	20829085	20829085	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtactcaagttatcctcacCaaggaagaccaggttactgt	8	10	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:20829085C>A	uc002npb.1	-	2	280	c.130G>T	c.(130-132)GGT>TGT	p.G44C	ZNF626_uc002npc.1_Intron|ZNF626_uc002npd.1_Missense_Mutation_p.G44C	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTATCCTCACCAAGGAAGACC	0.333													1	0	1.05317e-09	0.020292	1.21054e-09	13	80										A	20829085	C	A	20829085	3	1	56	1	0	0	0	0	1	0	0	0	18047	608	21	4	1525	4	ZNF626	19	20829085	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	564	20829085	38299898	205	16437										
MLL4	9757	broad.mit.edu	37	chr19	36212397	36212397	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gtggtcaccactcctgttaaGgccgaggtgtcccctcacgg	12	14	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:36212397G>C	uc010eei.2	+	3	2148	c.2148G>C	c.(2146-2148)AAG>AAC	p.K716N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	716	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCTGTTAAGGCCGAGGTGT	0.657													0	0	0	0.00499	0	15	76										C	36212397	G	C	36212397	3	2	56	1	0	0	0	0	1	0	0	0	9623	991	35	4	2158	4	MLL4	19	36212397	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	15383312	36212397	22916586	206	16438										
ZNF383	163087	broad.mit.edu	37	chr19	37733545	37733545	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acaactgggatatccaaatgGgcattttagtcaagaaatat	8	6	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:37733545G>C	uc002oft.1	+	8	987	c.407G>C	c.(406-408)GGG>GCG	p.G136A	ZNF383_uc002ofs.1_Missense_Mutation_p.G71A|ZNF383_uc002ofu.1_Missense_Mutation_p.G136A	NM_152604	NP_689817	Q8NA42	ZN383_HUMAN	zinc finger protein 383	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATCCAAATGGGCATTTTAGT	0.378													0	0	0	0.008871	0	17	82										C	37733545	G	C	37733545	3	2	56	1	0	0	0	0	1	0	0	0	17871	1232	43	4	421	4	ZNF383	19	37733545	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1521148	37733545	21395438	207	16439										
FBXO27	126433	broad.mit.edu	37	chr19	39521746	39521746	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcctcctctaggtccaagacCtgcttcttgcaacaccagct	6	16	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:39521746C>G	uc002okh.2	-	4	577	c.495G>C	c.(493-495)CAG>CAC	p.Q165H		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	165	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GGTCCAAGACCTGCTTCTTGC	0.527													0	0	0	0.012213	0	29	144										G	39521746	C	G	39521746	3	3	56	1	0	0	0	0	1	0	0	0	5737	680	24	4	368	4	FBXO27	19	39521746	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1788201	39521746	19607237	208	16440										
HIPK4	147746	broad.mit.edu	37	chr19	40895437	40895437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agccagctccttgagccgggCcagggctgtgagcacctgca	14	14	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:40895437C>T	uc002onp.2	-	1	658	c.373G>A	c.(373-375)GCC>ACC	p.A125T		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	125	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TTGAGCCGGGCCAGGGCTGTG	0.602													0	0	0	0.01892	0	19	92										T	40895437	C	T	40895437	3	4	56	1	0	0	0	0	1	0	0	0	7119	739	26	2	1493	2	HIPK4	19	40895437	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	1373691	40895437	18233546	209	16441										
CYP2A7	1549	broad.mit.edu	37	chr19	41386396	41386396	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttactcaccgtgcgtgctccGgatggcctcgatgaggaagc	13	12	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:41386396G>T	uc002opm.2	-	3	1023	c.481C>A	c.(481-483)CGG>AGG	p.R161R	CYP2A7_uc002opo.2_Silent_p.R161R|CYP2A7_uc002opn.2_Silent_p.R110R	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	161						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TGCGTGCTCCGGATGGCCTCG	0.662													1	0	1.836e-18	0.017118	2.16851e-18	29	173										T	41386396	G	T	41386396	2	4	56	1	0	0	0	0	0	0	0	1	4163	1115	39	4		4	CYP2A7	19	41386396	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	490959	41386396	17742587	210	16442										
IRGC	56269	broad.mit.edu	37	chr19	44223733	44223733	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gccaacgaggtctcgcctgaGactgtcctgcggctctattc	11	14	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:44223733G>A	uc002oxh.2	+	2	1170	c.1023G>A	c.(1021-1023)GAG>GAA	p.E341E		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	341						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				TCTCGCCTGAGACTGTCCTGC	0.677													0	0	0	0.010729	0	10	64										A	44223733	G	A	44223733	2	1	56	1	0	0	0	0	0	0	0	1	7838	933	33	1		1	IRGC	19	44223733	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2837337	44223733	14905250	211	16443										
ZNF227	7770	broad.mit.edu	37	chr19	44739769	44739769	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcggttggagtgttaatctcCgtgttcaccagagggtccac	12	10	2	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:44739769C>T	uc002oyu.2	+	6	1391	c.1186C>T	c.(1186-1188)CGT>TGT	p.R396C	ZNF227_uc010xwu.1_Missense_Mutation_p.R345C|ZNF227_uc002oyv.2_Missense_Mutation_p.R396C|ZNF227_uc010xwv.1_Missense_Mutation_p.R345C|ZNF227_uc010xww.1_Missense_Mutation_p.R317C|ZNF227_uc002oyw.2_Missense_Mutation_p.R368C|ZNF227_uc010ejh.2_Missense_Mutation_p.R389C|ZNF235_uc002oyx.1_Intron	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	396	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				TGTTAATCTCCGTGTTCACCA	0.463													0	0	0	0.008871	0	19	39										T	44739769	C	T	44739769	3	4	56	1	0	0	0	0	1	0	0	0	17778	652	23	2	1200	2	ZNF227	19	44739769	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	516036	44739769	14389214	212	16444										
ZFP112	7771	broad.mit.edu	37	chr19	44832239	44832239	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	actgaaactcttaccacactCatcacattggtatggcttct	5	12	4	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:44832239C>G	uc010ejj.2	-	5	2202	c.2089G>C	c.(2089-2091)GAG>CAG	p.E697Q	ZFP112_uc002ozc.3_Missense_Mutation_p.E691Q|ZFP112_uc010xwy.1_Missense_Mutation_p.E714Q|ZFP112_uc010xwz.1_Missense_Mutation_p.E696Q	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	697	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTACCACACTCATCACATTGG	0.448													0	0	0	0.00308	0	8	41										G	44832239	C	G	44832239	3	3	56	1	0	0	0	0	1	0	0	0	17635	835	29	1	656	1	ZFP112	19	44832239	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	92470	44832239	14296744	213	16445										
FBXO46	23403	broad.mit.edu	37	chr19	46216736	46216736	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	caccatagctggaagggcagGaggctcccacggtccatgct	13	13	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:46216736G>A	uc002pcy.2	-	2	143	c.18C>T	c.(16-18)CTC>CTT	p.L6L	FBXO46_uc002pcz.2_Silent_p.L6L	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	6							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GGAAGGGCAGGAGGCTCCCAC	0.657													0	0	0	0.001168	0	5	68										A	46216736	G	A	46216736	2	1	56	1	0	0	0	0	0	0	0	1	5755	1161	41	1		1	FBXO46	19	46216736	Silent	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1384497	46216736	12912247	214	16446										
CCDC8	83987	broad.mit.edu	37	chr19	46914959	46914959	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acctctggtcagctggggccTctgccctctgattatctgca	10	14	5	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:46914959T>C	uc002pep.2	-	1	1961	c.1109A>G	c.(1108-1110)GAG>GGG	p.E370G		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	370						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		AGCTGGGGCCTCTGCCCTCTG	0.607													0	0	0	0.004482	0	5	227										C	46914959	T	C	46914959	3	2	56	1	0	0	0	0	1	0	0	0	2853	1551	54	5	511	5	CCDC8	19	46914959	Missense_Mutation	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	698223	46914959	12214024	215	16447										
DHX34	9704	broad.mit.edu	37	chr19	47865903	47865903	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atgatgccttcgccccctacCccgtcccagaaattcggagg	9	16	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:47865903C>G	uc010xyn.1	+	6	1887	c.1546C>G	c.(1546-1548)CCC>GCC	p.P516A	DHX34_uc010elc.1_Missense_Mutation_p.P431A	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	516	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CGCCCCCTACCCCGTCCCAGA	0.652													0	0	0	0.003163	0	12	40										G	47865903	C	G	47865903	3	3	56	1	0	0	0	0	1	0	0	0	4507	623	22	4	1564	4	DHX34	19	47865903	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	950944	47865903	11263080	216	16448										
AP2A1	160	broad.mit.edu	37	chr19	50302585	50302585	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ttgtggcccctgctggcagtGagcccaacctcctggttcgg	13	14	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:50302585G>C	uc002ppn.2	+	9	1178	c.967G>C	c.(967-969)GAG>CAG	p.E323Q	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Missense_Mutation_p.E323Q|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	323					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		TGCTGGCAGTGAGCCCAACCT	0.637													0	0	0	0.020292	0	11	31										C	50302585	G	C	50302585	3	2	56	1	0	0	0	0	1	0	0	0	739	1304	45	1	1001	1	AP2A1	19	50302585	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2436682	50302585	8826398	217	16449										
LILRA2	11027	broad.mit.edu	37	chr19	55086317	55086318	+	Nonsense_Mutation	DNP	GG	GG	TA													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gcttcattctgtgtaaggaaGgagaagatgaacacccacaa							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55086317_55086318GG>TA	uc002qgg.3	+	4	561_562	c.472_473GG>TA	c.(472-474)GGA>TAA	p.G158*	LILRA2_uc010ern.2_Nonsense_Mutation_p.G158*|LILRA2_uc002qgf.2_Nonsense_Mutation_p.G158*|LILRA2_uc010yfe.1_Nonsense_Mutation_p.G158*|LILRA2_uc010yff.1_Nonsense_Mutation_p.G146*|LILRA2_uc010ero.2_Nonsense_Mutation_p.G146*|LILRA2_uc010yfg.1_Nonsense_Mutation_p.G158*	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	158	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		GTGTAAGGAAGGAGAAGATGAA	0.604													0	0	0	0.004672	0	24	162										TA	55086318	GG	TA	55086317	4	4	56	1	0	0	0	0	0	1	0	0	8785	1001	35	4	486	4	LILRA2	19	55086317	Nonsense_Mutation	DNP	GG	TCGA-DK-A3IK-01A-32D-A21A-08	4783732	55086317	4042666	218	16450										
LILRA1	11024	broad.mit.edu	37	chr19	55106715	55106715	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	acacccacaatgcctgaactCacagccccgtacccatgggt	7	17	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55106715C>G	uc002qgh.1	+	5	691	c.509C>G	c.(508-510)TCA>TGA	p.S170*	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Nonsense_Mutation_p.S170*	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	170	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGCCTGAACTCACAGCCCCGT	0.567													0	0	0	0.00874	0	36	208										G	55106715	C	G	55106715	4	3	56	1	0	0	0	0	0	1	0	0	8784	838	29	1	523	1	LILRA1	19	55106715	Nonsense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	20398	55106715	4022268	219	16451										
KIR3DL1	3811	broad.mit.edu	37	chr19	55341573	55341573	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggactctgatgaacaagaccCtgaggaggtgacatacgcac	12	10	1	5	rs1130473		TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55341573C>G	uc002qhk.3	+	9	1241	c.1178C>G	c.(1177-1179)CCT>CGT	p.P393R	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.P318R|KIR3DL1_uc010esf.2_Missense_Mutation_p.P298R|KIR3DL1_uc010yfo.1_Missense_Mutation_p.P335R|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	393	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		GAACAAGACCCTGAGGAGGTG	0.522													0	0	0	0.01441	0	85	410										G	55341573	C	G	55341573	3	3	56	1	0	0	0	0	1	0	0	0	8320	681	24	4	1212	4	KIR3DL1	19	55341573	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	234858	55341573	3787410	220	16452										
TNNT1	7138	broad.mit.edu	37	chr19	55653248	55653248	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gaagtcaacgcgctccccttCtgggatctttggcgggatca	12	12	4	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr19:55653248C>G	uc002qjb.3	-	7	258	c.169G>C	c.(169-171)GAA>CAA	p.E57Q	TNNT1_uc002qiz.3_5'UTR|TNNT1_uc002qja.3_5'UTR|TNNT1_uc002qjc.3_Missense_Mutation_p.E57Q|TNNT1_uc002qje.3_Missense_Mutation_p.E46Q|TNNT1_uc002qjd.3_Missense_Mutation_p.E46Q|TNNT1_uc002qjf.2_Missense_Mutation_p.E53Q	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	57					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CGCTCCCCTTCTGGGATCTTT	0.448													0	0	0	0.011902	0	35	212										G	55653248	C	G	55653248	3	3	56	1	0	0	0	0	1	0	0	0	16327	922	32	1	699	1	TNNT1	19	55653248	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	311675	55653248	3475735	221	16453										
ZCCHC3	85364	broad.mit.edu	37	chr20	278815	278815	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atcctgcgctccatcggcatGgacccgagcgacatctacgc	10	16	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:278815G>C	uc002wdf.2	+	2	609	c.585G>C	c.(583-585)ATG>ATC	p.M195I	ZCCHC3_uc002wdg.2_Intron	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	196							nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCATCGGCATGGACCCGAGCG	0.647													0	0	0	0.004482	0	7	43										C	278815	G	C	278815	3	2	56	1	0	0	0	0	1	0	0	0	17586	1348	47	4	590	4	ZCCHC3	20	278815	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		278815	62746705	222	16454										
MAVS	57506	broad.mit.edu	37	chr20	3846784	3846784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggtggtgctgtaccggcggcGtctgcactagtgaagccctg	16	11	1	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:3846784G>A	uc002wjw.3	+	7	1782	c.1613G>A	c.(1612-1614)CGT>CAT	p.R538H	MAVS_uc002wjx.3_Missense_Mutation_p.R397H|MAVS_uc002wjy.3_Missense_Mutation_p.R236H	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	538	Mitochondrial intermembrane (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						TACCGGCGGCGTCTGCACTAG	0.637													0	0	0	0.013537	0	9	48										A	3846784	G	A	3846784	3	1	56	1	0	0	0	0	1	0	0	0	9338	1145	40	2	1635	2	MAVS	20	3846784	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	3567969	3846784	59178736	223	16455										
SPTLC3	55304	broad.mit.edu	37	chr20	13074186	13074186	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atcgcttgtgcttggggcccGactctcaggtgcaaccataa	11	12	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:13074186G>T	uc002wod.1	+	6	1077	c.788G>T	c.(787-789)CGA>CTA	p.R263L		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	263					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	CTTGGGGCCCGACTCTCAGGT	0.398													1	0	1.26484e-09	0.00308	1.4483e-09	6	77										T	13074186	G	T	13074186	3	4	56	1	0	0	0	0	1	0	0	0	15124	1058	37	3	810	3	SPTLC3	20	13074186	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	9227402	13074186	49951334	224	16456										
E2F1	1869	broad.mit.edu	37	chr20	32264765	32264765	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cacgggagcccgcaggctgcCcatccgggacaacagcggtt	14	15	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:32264765C>G	uc002wzu.3	-	7	1227	c.1087G>C	c.(1087-1089)GGC>CGC	p.G363R	NECAB3_uc002wzm.3_5'Flank|NECAB3_uc002wzn.3_5'Flank|NECAB3_uc002wzo.3_5'Flank|NECAB3_uc002wzp.3_5'Flank|NECAB3_uc002wzq.3_5'Flank|NECAB3_uc002wzr.3_5'Flank|NECAB3_uc010geo.2_5'Flank	NM_005225	NP_005216	Q01094	E2F1_HUMAN	E2F transcription factor 1	363	Required for interaction with TRIM28.				apoptosis|cell proliferation|G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|mRNA stabilization|negative regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of fibroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle	mitochondrion|Rb-E2F complex	sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding				0						CGCAGGCTGCCCATCCGGGAC	0.726													0	0	0	0.00308	0	5	18										G	32264765	C	G	32264765	3	3	56	1	0	0	0	0	1	0	0	0	4866	623	22	4	230	4	E2F1	20	32264765	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	19190579	32264765	30760755	225	16457										
DLGAP4	22839	broad.mit.edu	37	chr20	35068239	35068239	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aggactacacccccgtcagcGacagcctcaacgactccagc	8	18	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:35068239G>A	uc002xff.2	+	5	1759	c.1324G>A	c.(1324-1326)GAC>AAC	p.D442N	DLGAP4_uc010zvp.1_Missense_Mutation_p.D442N	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	442					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCCGTCAGCGACAGCCTCAA	0.632											OREG0025903	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	14	53										A	35068239	G	A	35068239	3	1	56	1	0	0	0	0	1	0	0	0	4562	1058	37	1	1334	1	DLGAP4	20	35068239	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	2803474	35068239	27957281	226	16458										
DSN1	79980	broad.mit.edu	37	chr20	35383166	35383166	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccctcaagagacaagcttacCgagctgtactgacaccttct	7	14	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:35383166C>G	uc010gfr.2	-	10	1334	c.961G>C	c.(961-963)GGA>CGA	p.G321R	DSN1_uc002xfz.2_Missense_Mutation_p.G321R|DSN1_uc002xfy.3_Missense_Mutation_p.G111R|DSN1_uc002xga.2_Missense_Mutation_p.G321R|DSN1_uc010zvs.1_Missense_Mutation_p.G214R|DSN1_uc002xgc.2_Missense_Mutation_p.G305R|DSN1_uc002xgb.2_Missense_Mutation_p.G305R	NM_001145316	NP_001138788	Q9H410	DSN1_HUMAN	DSN1, MIND kinetochore complex component,	321					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			ovary(2)	2		Myeloproliferative disorder(115;0.00874)				ACAAGCTTACCGAGCTGTACT	0.473													0	0	0	0.014758	0	5	35										G	35383166	C	G	35383166	3	3	56	1	0	0	0	0	1	0	0	0	4780	666	23	4	117	4	DSN1	20	35383166	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	314927	35383166	27642354	227	16459										
RPN2	6185	broad.mit.edu	37	chr20	35865107	35865107	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	atgctggcccagcaggcagtCaagaggtaaggccagacatg	14	10	1	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:35865107C>G	uc002xgp.2	+	16	2182	c.1878C>G	c.(1876-1878)GTC>GTG	p.V626V	RPN2_uc002xgq.2_Silent_p.V594V	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	626	Cytoplasmic (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AGCAGGCAGTCAAGAGGTAAG	0.532													0	0	0	0.020292	0	12	85										G	35865107	C	G	35865107	2	3	56	1	0	0	0	0	0	0	0	1	13608	813	29	1		1	RPN2	20	35865107	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	481941	35865107	27160413	228	16460										
VSTM2L	128434	broad.mit.edu	37	chr20	36572409	36572409	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aaggtggtgggcagcaacatCtcccacaagctgcgcctgtc	12	13	1	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:36572409C>T	uc002xhk.3	+	4	623	c.369C>T	c.(367-369)ATC>ATT	p.I123I		NM_080607	NP_542174	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	123	Ig-like.									ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.00878)				GCAGCAACATCTCCCACAAGC	0.652													0	0	0	0.001984	0	5	42										T	36572409	C	T	36572409	2	4	56	1	0	0	0	0	0	0	0	1	17227	903	32	1		1	VSTM2L	20	36572409	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	707302	36572409	26453111	229	16461										
ZNFX1	57169	broad.mit.edu	37	chr20	47866170	47866170	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cacaaagtgagcctcatgctGgttctgatggcttttgccct	10	11	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:47866170G>T	uc002xui.2	-	14	3638	c.3391C>A	c.(3391-3393)CAG>AAG	p.Q1131K		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1131							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCCTCATGCTGGTTCTGATGG	0.493													1	0	2.56e-06	0.009096	2.81319e-06	4	125										T	47866170	G	T	47866170	3	4	56	1	0	0	0	0	1	0	0	0	18202	1357	47	4	2369	4	ZNFX1	20	47866170	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	11293761	47866170	15159350	230	16462										
PHACTR3	116154	broad.mit.edu	37	chr20	58322813	58322813	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgtgtttgtgtgttgggcagCgctggagaagaagatggccg	18	5	0	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:58322813C>T	uc002yau.2	+	3	748	c.281C>T	c.(280-282)GCG>GTG	p.A94V	PHACTR3_uc002yat.2_Missense_Mutation_p.A91V|PHACTR3_uc010zzw.1_Missense_Mutation_p.A53V|PHACTR3_uc002yav.2_Missense_Mutation_p.A53V|PHACTR3_uc002yaw.2_Missense_Mutation_p.A53V|PHACTR3_uc002yax.2_Missense_Mutation_p.A53V	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	94	RPEL 1.					nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TGTTGGGCAGCGCTGGAGAAG	0.577													0	0	0	0.010818	0	30	119										T	58322813	C	T	58322813	3	4	56	1	0	0	0	0	1	0	0	0	11811	782	27	2	291	2	PHACTR3	20	58322813	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	10456643	58322813	4702707	231	16463										
DIDO1	11083	broad.mit.edu	37	chr20	61513532	61513532	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggggcggaggcggcggcgacCcaggaggtgtggtgctgaca	22	9	0	1			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:61513532C>A	uc002ydr.1	-	16	4040	c.3776G>T	c.(3775-3777)GGG>GTG	p.G1259V	DIDO1_uc002yds.1_Missense_Mutation_p.G1259V	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1259	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGGCGGCGACCCAGGAGGTGT	0.622													1	0	3.13743e-37	0.01441	3.74992e-37	66	262										A	61513532	C	A	61513532	3	1	56	1	0	0	0	0	1	0	0	0	4522	623	22	4	2950	4	DIDO1	20	61513532	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3190719	61513532	1511988	232	16464										
PCMTD2	55251	broad.mit.edu	37	chr20	62895852	62895854	+	In_Frame_Del	DEL	CTT	CTT	-													0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tatgcaaagcagaaactggaCttcttcatcagaacaagtga							TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr20:62895852_62895854delCTT	uc002yil.3	+	3	578_580	c.378_380delCTT	c.(376-381)GACTTC>GAC	p.F128del	PCMTD2_uc002yim.3_In_Frame_Del_p.F128del	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	128						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGAAACTGGACTTCTTCATCAGA	0.355																		8	74	---	---								-	62895854	CTT	-	62895852	7	5	56	1	0	1	0	1	0	0	0	0	11587	564	20	0	384	0	PCMTD2	20	62895852	In_Frame_Del	DEL	CTT	TCGA-DK-A3IK-01A-32D-A21A-08	1382320	62895852	129668	233	16465										
KRTAP19-1	337882	broad.mit.edu	37	chr21	31852400	31852400	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	aatccgtatcctccattgtaCgatgggcggcagcagccata	10	12	0	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:31852400C>T	uc011acx.1	-	1	237	c.237G>A	c.(235-237)TCG>TCA	p.S79S		NM_181607	NP_853638	Q8IUB9	KR191_HUMAN	keratin associated protein 19-1	79	26 X 2 AA repeats of G-[YCGS].					intermediate filament					0						CTCCATTGTACGATGGGCGGC	0.493													0	0	0	0.017118	0	30	258										T	31852400	C	T	31852400	2	4	56	1	0	0	0	0	0	0	0	1	8528	523	19	2		2	KRTAP19-1	21	31852400	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08		31852400	16277495	234	16466										
DNAJC28	54943	broad.mit.edu	37	chr21	34861116	34861116	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	cgttctatagcttgcgttatCttttgctgtttgctctgtct	8	9	4	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:34861116C>A	uc002yrv.2	-	2	1034	c.585G>T	c.(583-585)AAG>AAT	p.K195N	DNAJC28_uc002yrw.2_Missense_Mutation_p.K195N	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	195							heat shock protein binding				0						CTTGCGTTATCTTTTGCTGTT	0.373													1	0	1.67942e-08	0.006122	1.88698e-08	17	59										A	34861116	C	A	34861116	3	1	56	1	0	0	0	0	1	0	0	0	4646	912	32	3	585	3	DNAJC28	21	34861116	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	3008716	34861116	13268779	235	16467										
SETD4	54093	broad.mit.edu	37	chr21	37408469	37408469	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcggcagatgccctgagaatCtttagctcttccgtccacaa	8	13	2	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:37408469C>G	uc002yuw.1	-	10	2642	c.1269G>C	c.(1267-1269)AAG>AAC	p.K423N	SETD4_uc002yux.1_Missense_Mutation_p.K399N|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.K423N	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	423				EILVKYLPSTDKQMDKKISILKDHGYIENLTFGWDGPSWRL LTALKLLCLEAEKFTCWKKVLLGEVISDTNEKTSLDIAQKI CYYFIEETNAVLQKVSHMKDEKEALINQLTLVESLWTEELK ILRASAETLHSLQTAFT -> GWNQLCS (in Ref. 5; AAH02898).						large_intestine(1)|ovary(1)	2						CCCTGAGAATCTTTAGCTCTT	0.443													0	0	0	0.01441	0	38	132										G	37408469	C	G	37408469	3	3	56	1	0	0	0	0	1	0	0	0	14133	912	32	1	57	1	SETD4	21	37408469	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2547353	37408469	10721426	236	16468										
UBASH3A	53347	broad.mit.edu	37	chr21	43854960	43854960	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agggaaatactacaggccagAcctgaatttcccctgcagtc	9	12	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:43854960A>T	uc002zbe.2	+	10	1325	c.1289A>T	c.(1288-1290)GAC>GTC	p.D430V	UBASH3A_uc002zbf.2_Missense_Mutation_p.D392V|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.D392V	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	430	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						TACAGGCCAGACCTGAATTTC	0.443													0	0	0	0.00499	0	14	39										T	43854960	A	T	43854960	3	4	56	1	0	0	0	0	1	0	0	0	16836	275	10	5	1327	5	UBASH3A	21	43854960	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08	6446491	43854960	4274935	237	16469										
KRTAP10-7	386675	broad.mit.edu	37	chr21	46021232	46021232	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	caggcctgctgtgtgcctgtCtgctgcaagcccgtctgctg	13	14	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:46021232C>G	uc002zfn.3	+	2	721	c.696C>G	c.(694-696)GTC>GTG	p.V232V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	keratin associated protein 10-7	237	30 X 5 AA repeats of C-C-X(3).|17.					keratin filament					0						GTGTGCCTGTCTGCTGCAAGC	0.652													0	0	0	0.01441	0	34	345										G	46021232	C	G	46021232	2	3	56	1	0	0	0	0	0	0	0	1	8514	900	32	1		1	KRTAP10-7	21	46021232	Silent	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	2166272	46021232	2108663	238	16470										
PCNT	5116	broad.mit.edu	37	chr21	47847581	47847581	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggagaggggaccttctgcagGttgtgcaagaggcctttgaa	16	7	1	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr21:47847581G>A	uc002zji.3	+	34	7473	c.7366G>A	c.(7366-7368)GTT>ATT	p.V2456I	PCNT_uc002zjj.2_Missense_Mutation_p.V2338I	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2456					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CCTTCTGCAGGTTGTGCAAGA	0.577													0	0	0	0.008871	0	19	86										A	47847581	G	A	47847581	3	1	56	1	0	0	0	0	1	0	0	0	11590	1261	44	2	7500	2	PCNT	21	47847581	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	1826349	47847581	282314	239	16471										
DGCR8	54487	broad.mit.edu	37	chr22	20074017	20074017	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ggggtaggcatagggggtgaGagtgctgataagaaggatga	20	2	0	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr22:20074017G>C	uc002zri.2	+	2	881	c.531G>C	c.(529-531)GAG>GAC	p.E177D	DGCR8_uc010grz.2_Missense_Mutation_p.E177D|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	177	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TAGGGGGTGAGAGTGCTGATA	0.537													0	0	0	0.01441	0	68	471										C	20074017	G	C	20074017	3	2	56	1	0	0	0	0	1	0	0	0	4464	933	33	1	533	1	DGCR8	22	20074017	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08		20074017	31230549	240	16472										
TOM1	10043	broad.mit.edu	37	chr22	35719129	35719129	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	ccatcctgcccaagaacaacCcacccaccatcgtgcatgac	5	19	0	2			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chr22:35719129C>A	uc003ann.2	+	4	450	c.325C>A	c.(325-327)CCA>ACA	p.P109T	TOM1_uc011ami.1_Missense_Mutation_p.P76T|TOM1_uc011amj.1_5'UTR|TOM1_uc003ans.2_5'UTR|TOM1_uc011amk.1_Missense_Mutation_p.P71T|TOM1_uc003anp.2_Missense_Mutation_p.P109T|TOM1_uc011aml.1_Missense_Mutation_p.P109T|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Missense_Mutation_p.P103T|TOM1_uc003anr.2_5'UTR	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	109	VHS.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CAAGAACAACCCACCCACCAT	0.602													1	0	4.68919e-08	0.008291	5.24909e-08	8	67										A	35719129	C	A	35719129	3	1	56	1	0	0	0	0	1	0	0	0	16348	623	22	4	339	4	TOM1	22	35719129	Missense_Mutation	SNP	C	TCGA-DK-A3IK-01A-32D-A21A-08	15645112	35719129	15585437	241	16473										
IQSEC2	23096	broad.mit.edu	37	chrX	53270978	53270978	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	gctcataccacaaggagatcAttgaagaggaagacctcccg	10	11	2	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:53270978A>T	uc004dsd.2	-	10	3204	c.3003T>A	c.(3001-3003)AAT>AAA	p.N1001K	IQSEC2_uc004dsc.2_Missense_Mutation_p.N796K	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	991	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						CAAGGAGATCATTGAAGAGGA	0.557													0	0	0	0.008291	0	9	29										T	53270978	A	T	53270978	3	4	56	1	0	0	0	0	1	0	0	0	7818	214	8	5	1487	5	IQSEC2	23	53270978	Missense_Mutation	SNP	A	TCGA-DK-A3IK-01A-32D-A21A-08		53270978	101999582	242	16474										
HEPH	9843	broad.mit.edu	37	chrX	65476064	65476064	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tgttgttcttgatttttgatGaaaataagtcttggtatttg	9	2	2	3			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:65476064G>A	uc011moz.1	+	17	2857	c.2797G>A	c.(2797-2799)GAA>AAA	p.E933K	HEPH_uc004dwn.2_Missense_Mutation_p.E933K|HEPH_uc004dwo.2_Missense_Mutation_p.E663K|HEPH_uc010nkr.2_Missense_Mutation_p.E741K|HEPH_uc011mpa.1_Missense_Mutation_p.E933K|HEPH_uc010nks.2_Missense_Mutation_p.E222K	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	930	Extracellular (Potential).|Plastocyanin-like 6.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GATTTTTGATGAAAATAAGTC	0.473													0	0	0	0.016723	0	13	25										A	65476064	G	A	65476064	3	1	56	1	0	0	0	0	1	0	0	0	7054	1291	45	1	3016	1	HEPH	23	65476064	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	12205086	65476064	89794496	243	16475										
ARMCX1	51309	broad.mit.edu	37	chrX	100808026	100808026	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	agacgagaacgagaaaatctGggacgaagacgaggagtcta	14	6	2	4			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:100808026G>C	uc004ehv.2	+	4	484	c.113G>C	c.(112-114)TGG>TCG	p.W38S	ARMCX1_uc004ehw.2_Missense_Mutation_p.W38S	NM_016608	NP_057692	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	38						integral to membrane	binding			ovary(3)|pancreas(1)	4						GAGAAAATCTGGGACGAAGAC	0.567													0	0	0	0.006214	0	9	26										C	100808026	G	C	100808026	3	2	56	1	0	0	0	0	1	0	0	0	959	1357	47	4	115	4	ARMCX1	23	100808026	Missense_Mutation	SNP	G	TCGA-DK-A3IK-01A-32D-A21A-08	35331962	100808026	54462534	244	16476										
MORF4L2	9643	broad.mit.edu	37	chrX	102931203	102931203	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.277551020408163	68	2.41788626168486e-15	2.81304566296087	3.45605322338831	2.16297208538588	0.013608836075189	0.0421225878517755	44	tcatgcaaatagcccaacaaTaatgcaaggcttttctcatc	5	11	2	0			TCGA-DK-A3IK-01A-32D-A21A-08	TCGA-DK-A3IK-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f730e341-8102-4405-95e2-46a3455a35cc	afd71eba-ed7c-408d-94eb-8e606faafc73	g.chrX:102931203T>C	uc004ekw.2	-	4	1985	c.753A>G	c.(751-753)TTA>TTG	p.L251L	MORF4L2_uc004ela.2_Silent_p.L251L|MORF4L2_uc004ekx.2_Silent_p.L251L|MORF4L2_uc004elb.2_Silent_p.L251L|MORF4L2_uc004eky.2_Silent_p.L251L|MORF4L2_uc010nos.2_Silent_p.L251L|MORF4L2_uc004ekz.2_Silent_p.L251L|MORF4L2_uc011mry.1_Silent_p.L251L|MORF4L2_uc011mrz.1_Silent_p.L251L|MORF4L2_uc004elc.2_Silent_p.L251L|MORF4L2_uc004elf.2_Silent_p.L251L|MORF4L2_uc004ele.2_Silent_p.L251L|MORF4L2_uc011msa.1_Silent_p.L251L|MORF4L2_uc011msb.1_Silent_p.L251L|MORF4L2_uc011msc.1_Silent_p.L251L|MORF4L2_uc011msd.1_Silent_p.L251L|MORF4L2_uc004eld.2_Silent_p.L251L	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	251					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						AGCCCAACAATAATGCAAGGC	0.423													0	0	0	0.009096	0	4	32										C	102931203	T	C	102931203	2	2	56	1	0	0	0	0	0	0	0	1	9707	1403	49	5		5	MORF4L2	23	102931203	Silent	SNP	T	TCGA-DK-A3IK-01A-32D-A21A-08	2123177	102931203	52339357	245	16477										
H6PD	9563	broad.mit.edu	37	chr1	9324741	9324741	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccagccacaccgccgcatgaGccttagcctgcctctcatca	7	19	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:9324741G>T	uc001apt.2	+	5	2462	c.2189G>T	c.(2188-2190)AGC>ATC	p.S730I		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	730	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CGCCGCATGAGCCTTAGCCTG	0.652													1	0	3.27435e-08	0.00245	3.62959e-08	8	27										T	9324741	G	T	9324741	3	4	57	1	0	0	0	0	1	0	0	0	6936	971	34	4	2203	4	H6PD	1	9324741	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		9324741	239925880	1	16478										
DDI2	84301	broad.mit.edu	37	chr1	15978267	15978267	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctcccagaccacctttcttCctgagggagagctaccagag	10	14	1	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:15978267C>G	uc001awx.1	+	8	1156	c.1060C>G	c.(1060-1062)CCT>GCT	p.P354A	DDI2_uc009voj.1_Missense_Mutation_p.P95A	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	354					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		CACCTTTCTTCCTGAGGGAGA	0.502													0	0	0	0.010729	0	9	50										G	15978267	C	G	15978267	3	3	57	1	0	0	0	0	1	0	0	0	4329	855	30	1	1090	1	DDI2	1	15978267	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	6653526	15978267	233272354	2	16479										
FAM43B	163933	broad.mit.edu	37	chr1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcagcatccaggaggaggacGaggaggaggaggaggacgac							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:20880268_20880270delGAG	uc001bdj.2	+	1	1337_1339	c.802_804delGAG	c.(802-804)GAGdel	p.E272del		NM_207334	NP_997217	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272											0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.567																		7	11	---	---								-	20880270	GAG	-	20880268	7	5	57	1	0	1	0	1	0	0	0	0	5563	1059	37	0	804	0	FAM43B	1	20880268	In_Frame_Del	DEL	GAG	TCGA-DK-A3IL-01A-11D-A20D-08	4902001	20880268	228370353	3	16480										
GRHL3	57822	broad.mit.edu	37	chr1	24663111	24663112	+	Frame_Shift_Ins	INS	-	-	A													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gaataacctgatgagcttggINSagggggccttgcccacccct							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:24663111_24663112insA	uc001biy.2	+	4	467_468	c.421_422insA	c.(421-423)GAGfs	p.E141fs	GRHL3_uc001bix.2_Frame_Shift_Ins_p.E136fs|GRHL3_uc001biz.2_Frame_Shift_Ins_p.E43fs	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	136					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATGAGCTTGGAGGGGGCCTTG	0.579																		27	85	---	---								A	24663112	-	A	24663111	7	5	57	1	0	1	1	0	0	0	0	0	6765	1175	41	0	456	0	GRHL3	1	24663111	Frame_Shift_Ins	INS	-	TCGA-DK-A3IL-01A-11D-A20D-08	3782843	24663111	224587510	4	16481										
GRHL3	57822	broad.mit.edu	37	chr1	24668758	24668758	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gccagatcaagatcttctgtGacaaggtggctggactgggc	14	9	3	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:24668758G>T	uc001biy.2	+	9	1262	c.1216G>T	c.(1216-1218)GAC>TAC	p.D406Y	GRHL3_uc001bix.2_Missense_Mutation_p.D401Y|GRHL3_uc001biz.2_Missense_Mutation_p.D308Y	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	401					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GATCTTCTGTGACAAGGTGGC	0.577													1	0	2.43468e-25	0.01441	3.16105e-25	41	30										T	24668758	G	T	24668758	3	4	57	1	0	0	0	0	1	0	0	0	6765	1290	45	3	1271	3	GRHL3	1	24668758	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	5647	24668758	224581863	5	16482										
EXTL1	2134	broad.mit.edu	37	chr1	26349272	26349272	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cggcccggggcttcccaaggCtggccccgctggctggatgc	16	16	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:26349272C>T	uc001blf.2	+	1	1002	c.135C>T	c.(133-135)GGC>GGT	p.G45G		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	45	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CTTCCCAAGGCTGGCCCCGCT	0.652													0	0	0	0.004482	0	7	9										T	26349272	C	T	26349272	2	4	57	1	0	0	0	0	0	0	0	1	5325	784	28	2		2	EXTL1	1	26349272	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1680514	26349272	222901349	6	16483										
UBXN11	91544	broad.mit.edu	37	chr1	26610895	26610895	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	caaggccttgtgcatcagctGcctgcccaccacacggccct	9	18	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:26610895G>A	uc001blw.2	-	12	1204	c.931C>T	c.(931-933)CAG>TAG	p.Q311*	UBXN11_uc001blz.1_Nonsense_Mutation_p.Q278*|UBXN11_uc001blv.2_Nonsense_Mutation_p.Q273*|UBXN11_uc001bly.2_Nonsense_Mutation_p.Q191*|UBXN11_uc001blx.2_Nonsense_Mutation_p.Q69*|UBXN11_uc001bma.2_Nonsense_Mutation_p.Q278*|UBXN11_uc001bmb.1_Nonsense_Mutation_p.Q311*|UBXN11_uc010ofb.1_3'UTR|UBXN11_uc010ofc.1_3'UTR	NM_183008	NP_892120	Q5T124	UBX11_HUMAN	socius isoform 2	311						cytoplasm|cytoskeleton				ovary(1)	1						TGCATCAGCTGCCTGCCCACC	0.627													0	0	0	0.00499	0	14	33										A	26610895	G	A	26610895	4	1	57	1	0	0	0	0	0	1	0	0	16910	1328	46	2	651	2	UBXN11	1	26610895	Nonsense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	261623	26610895	222639726	7	16484										
GRIK3	2899	broad.mit.edu	37	chr1	37270762	37270762	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccgctgccccgccaccacttCtccttcatgatatgcagctt	6	18	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:37270762C>T	uc001caz.2	-	15	2526	c.2391G>A	c.(2389-2391)GAG>GAA	p.E797E	GRIK3_uc001cba.1_Silent_p.E797E	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	797	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GCCACCACTTCTCCTTCATGA	0.602													0	0	0	0.014323	0	20	62										T	37270762	C	T	37270762	2	4	57	1	0	0	0	0	0	0	0	1	6775	912	32	1		1	GRIK3	1	37270762	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	10659867	37270762	211979859	8	16485										
MACF1	23499	broad.mit.edu	37	chr1	39802313	39802313	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggtgtaaacccagagcccttCagagcaactcaggtcagtgg	12	11	3	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:39802313C>A	uc010oiu.1	+	1	5504	c.5373C>A	c.(5371-5373)TTC>TTA	p.F1791L	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3356					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGAGCCCTTCAGAGCAACTC	0.418													1	0	9.31168e-06	0.001855	9.90156e-06	12	10										A	39802313	C	A	39802313	3	1	57	1	0	0	0	0	1	0	0	0	9144	825	29	3	10144	3	MACF1	1	39802313	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	2531551	39802313	209448308	9	16486										
PTPRF	5792	broad.mit.edu	37	chr1	44086245	44086245	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtgagttcaaggtcacggatGcccgggtgagtgagtgcatt	16	7	2	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:44086245G>T	uc001cjr.2	+	31	5699	c.5359G>T	c.(5359-5361)GCC>TCC	p.A1787S	PTPRF_uc001cjs.2_Missense_Mutation_p.A1778S|PTPRF_uc001cju.2_Missense_Mutation_p.A1176S|PTPRF_uc009vwt.2_Missense_Mutation_p.A1347S|PTPRF_uc001cjv.2_Missense_Mutation_p.A1258S|PTPRF_uc001cjw.2_Missense_Mutation_p.A1013S	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1787	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGTCACGGATGCCCGGGTGAG	0.552													1	0	3.07415e-52	0.01441	4.17588e-52	113	126										T	44086245	G	T	44086245	3	4	57	1	0	0	0	0	1	0	0	0	12801	1319	46	4	5473	4	PTPRF	1	44086245	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	4283932	44086245	205164376	10	16487										
PODN	127435	broad.mit.edu	37	chr1	53540317	53540317	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgagcatctgaccaacctcaAttacctgtacttggccaata	6	12	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:53540317A>G	uc001cuv.2	+	4	597	c.590A>G	c.(589-591)AAT>AGT	p.N197S	PODN_uc001cuw.2_Missense_Mutation_p.N178S|PODN_uc010onr.1_Missense_Mutation_p.N178S|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	149	LRR 3.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						ACCAACCTCAATTACCTGTAC	0.562													0	0	0	0.01441	0	50	192										G	53540317	A	G	53540317	3	3	57	1	0	0	0	0	1	0	0	0	12178	101	4	5	604	5	PODN	1	53540317	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	9454072	53540317	195710304	11	16488										
USP24	23358	broad.mit.edu	37	chr1	55562240	55562240	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cagggtctcgtcatttaggtCaaattcttctataactgtgt	8	8	5	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:55562240C>A	uc001cyg.3	-	47	5512	c.5512G>T	c.(5512-5514)GAC>TAC	p.D1838Y		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1998					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						TCATTTAGGTCAAATTCTTCT	0.323													1	0	1.36615e-20	0.013726	1.69865e-20	28	11										A	55562240	C	A	55562240	3	1	57	1	0	0	0	0	1	0	0	0	17052	826	29	3	1946	3	USP24	1	55562240	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	2021923	55562240	193688381	12	16489										
PRKAA2	5563	broad.mit.edu	37	chr1	57169954	57169954	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccccaggcctgaaacctcatCcagaaaggatgccacctctt	7	16	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:57169954C>A	uc001cyk.3	+	7	1170	c.1099C>A	c.(1099-1101)CCA>ACA	p.P367T		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	367					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						GAAACCTCATCCAGAAAGGAT	0.468													1	0	1.96642e-18	0.006999	2.39434e-18	36	20										A	57169954	C	A	57169954	3	1	57	1	0	0	0	0	1	0	0	0	12494	855	30	3	1125	3	PRKAA2	1	57169954	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1607714	57169954	192080667	13	16490										
GPSM2	29899	broad.mit.edu	37	chr1	109439511	109439511	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aagcttcttgcctagagctgGccttggaaggggaacgtcta	13	9	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:109439511G>T	uc010ovc.1	+	3	578	c.82G>T	c.(82-84)GCC>TCC	p.A28S	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.A28S|GPSM2_uc010ove.1_Missense_Mutation_p.A28S	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	28	TPR 1.				G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		CCTAGAGCTGGCCTTGGAAGG	0.418													1	0	2.79147e-13	0.01441	3.27997e-13	40	135										T	109439511	G	T	109439511	3	4	57	1	0	0	0	0	1	0	0	0	6735	1203	42	4	88	4	GPSM2	1	109439511	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	52269557	109439511	139811110	14	16491										
OR10T2	128360	broad.mit.edu	37	chr1	158369175	158369175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gagaagaaagatgacaaaaaGcagcagctggagctccccca	11	10	0	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:158369175G>A	uc010pih.1	-	1	82	c.82C>T	c.(82-84)CTT>TTT	p.L28F		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					ATGACAAAAAGCAGCAGCTGG	0.488													0	0	0	0.00308	0	6	27										A	158369175	G	A	158369175	3	1	57	1	0	0	0	0	1	0	0	0	10919	971	34	2	864	2	OR10T2	1	158369175	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	48929664	158369175	90881446	15	16492										
ATP1A2	477	broad.mit.edu	37	chr1	160109741	160109741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcatcttcatctatgatgagGtccgaaagctcatcctgcgg	9	11	5	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:160109741G>A	uc001fvc.2	+	22	3133	c.3001G>A	c.(3001-3003)GTC>ATC	p.V1001I	ATP1A2_uc001fvd.2_Missense_Mutation_p.V720I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	1001	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTATGATGAGGTCCGAAAGCT	0.582													0	0	0	0.011902	0	33	68										A	160109741	G	A	160109741	3	1	57	1	0	0	0	0	1	0	0	0	1129	1261	44	2	3087	2	ATP1A2	1	160109741	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1740566	160109741	89140880	16	16493										
LMX1A	4009	broad.mit.edu	37	chr1	165175152	165175152	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gggtggggtgagaccctgtcGgaagggatctgagctgtaga	19	6	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:165175152G>A	uc001gcy.1	-	7	1158	c.937C>T	c.(937-939)CGA>TGA	p.R313*	LMX1A_uc001gcz.1_Nonsense_Mutation_p.R313*|LMX1A_uc001gcw.1_Nonsense_Mutation_p.R31*|LMX1A_uc001gcx.1_Nonsense_Mutation_p.R64*	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	313						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					AGACCCTGTCGGAAGGGATCT	0.582													0	0	0	0.010504	0	18	56										A	165175152	G	A	165175152	4	1	57	1	0	0	0	0	0	1	0	0	8861	1124	39	2	219	2	LMX1A	1	165175152	Nonsense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	5065411	165175152	84075469	17	16494										
LRRC52	440699	broad.mit.edu	37	chr1	165532872	165532872	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tacatcttcctgctgctcatCggcttctgcatcttcgccgc	7	16	4	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:165532872C>T	uc001gde.2	+	2	809	c.753C>T	c.(751-753)ATC>ATT	p.I251I	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	251	Helical; (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TGCTGCTCATCGGCTTCTGCA	0.587													0	0	0	0.003163	0	13	35										T	165532872	C	T	165532872	2	4	57	1	0	0	0	0	0	0	0	1	9010	874	31	1		1	LRRC52	1	165532872	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	357720	165532872	83717749	18	16495										
FMO3	2328	broad.mit.edu	37	chr1	171073019	171073019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcccagacttcccatttcccGatgacttccccaactttatg	4	16	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:171073019G>A	uc001ghi.2	+	3	337	c.226G>A	c.(226-228)GAT>AAT	p.D76N	FMO3_uc001ghh.2_Missense_Mutation_p.D76N|FMO3_uc010pmb.1_Missense_Mutation_p.D56N|FMO3_uc010pmc.1_Intron|MIR1295_hsa-mir-1295|MI0006357_5'Flank	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	76					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCCATTTCCCGATGACTTCCC	0.423													0	0	0	0.012213	0	31	20										A	171073019	G	A	171073019	3	1	57	1	0	0	0	0	1	0	0	0	5956	1058	37	1	232	1	FMO3	1	171073019	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	5540147	171073019	78177602	19	16496										
FMO2	2327	broad.mit.edu	37	chr1	171162520	171162520	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tatctatcaatctgtcgttaCcaacaccagcaaagaaatgt	5	10	3	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:171162520C>T	uc001ghk.1	+	3	296	c.179C>T	c.(178-180)ACC>ATC	p.T60I	FMO2_uc010pmd.1_5'UTR	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	60					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCTGTCGTTACCAACACCAGC	0.348													0	0	0	0.01441	0	75	62										T	171162520	C	T	171162520	3	4	57	1	0	0	0	0	1	0	0	0	5955	507	18	2	185	2	FMO2	1	171162520	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	89501	171162520	78088101	20	16497										
KDM5B	10765	broad.mit.edu	37	chr1	202709880	202709880	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gccgcaccattgggcagataTgcagggatctcttcgatttc	11	11	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:202709880T>C	uc001gyf.2	-	20	3122	c.3006A>G	c.(3004-3006)GCA>GCG	p.A1002A	KDM5B_uc009xag.2_Silent_p.A1038A|KDM5B_uc001gyg.1_Silent_p.A844A	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1002					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TGGGCAGATATGCAGGGATCT	0.443													0	0	0	0.001855	0	11	47										C	202709880	T	C	202709880	2	2	57	1	0	0	0	0	0	0	0	1	8134	1451	51	5		5	KDM5B	1	202709880	Silent	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	31547360	202709880	46540741	21	16498										
MDM4	4194	broad.mit.edu	37	chr1	204511994	204511994	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gagtgggatgtagctggcctGccttggtggtttttaggaaa	16	5	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:204511994G>A	uc001hba.2	+	8	756	c.594G>A	c.(592-594)CTG>CTA	p.L198L	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_Silent_p.L71L|MDM4_uc001hay.1_Silent_p.L198L|MDM4_uc001hbb.2_Silent_p.L71L|MDM4_uc010pqy.1_Intron|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	198					apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TAGCTGGCCTGCCTTGGTGGT	0.388			A		GBM|bladder|retinoblastoma								0	0	0	0.00278	0	19	39										A	204511994	G	A	204511994	2	1	57	1	0	0	0	0	0	0	0	1	9414	1306	46	2		2	MDM4	1	204511994	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1802114	204511994	44738627	22	16499										
SRGAP2	23380	broad.mit.edu	37	chr1	206626557	206626557	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccttctcagaatgtgagcccAtcgaggccattgccaagttt	9	12	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr1:206626557A>G	uc001hdy.2	+	17	2263	c.1930A>G	c.(1930-1932)ATC>GTC	p.I644V	SRGAP2_uc010prt.1_Missense_Mutation_p.I567V|SRGAP2_uc001hdx.2_Missense_Mutation_p.I644V|SRGAP2_uc010pru.1_Missense_Mutation_p.I567V|SRGAP2_uc010prv.1_Missense_Mutation_p.I568V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	731	SH3.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					ATGTGAGCCCATCGAGGCCAT	0.522													0	0	0	0.004672	0	2	2										G	206626557	A	G	206626557	3	3	57	1	0	0	0	0	1	0	0	0	15145	217	8	5	1997	5	SRGAP2	1	206626557	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	2114563	206626557	42624064	23	16500										
TPO	7173	broad.mit.edu	37	chr2	1488451	1488451	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggtccctatgaaggctatgaCtccaccgccaaccccactgt	8	16	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:1488451C>A	uc002qww.2	+	9	1513	c.1422C>A	c.(1420-1422)GAC>GAA	p.D474E	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.D474E|TPO_uc002qwr.2_Missense_Mutation_p.D474E|TPO_uc002qwx.2_Missense_Mutation_p.D474E|TPO_uc010yio.1_Missense_Mutation_p.D301E|TPO_uc010yip.1_Missense_Mutation_p.D474E|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	474	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AAGGCTATGACTCCACCGCCA	0.602													1	0	7.26314e-15	0.007291	8.70836e-15	28	32										A	1488451	C	A	1488451	3	1	57	1	0	0	0	0	1	0	0	0	16407	564	20	4	1452	4	TPO	2	1488451	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		1488451	241710922	24	16501										
MSGN1	343930	broad.mit.edu	37	chr2	17998252	17998252	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttacctgccacctgtctacaGccagagaggccagcctctca	8	16	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:17998252G>A	uc010yjt.1	+	1	467	c.467G>A	c.(466-468)AGC>AAC	p.S156N		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	156	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCTGTCTACAGCCAGAGAGGC	0.587													0	0	0	0.001855	0	12	27										A	17998252	G	A	17998252	3	1	57	1	0	0	0	0	1	0	0	0	9869	971	34	2	469	2	MSGN1	2	17998252	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	16509801	17998252	225201121	25	16502										
RHOB	388	broad.mit.edu	37	chr2	20647449	20647449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcctgcggccgctctcctacCcggacaccgacgtcattctc	9	19	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:20647449C>T	uc002rdv.2	+	1	615	c.223C>T	c.(223-225)CCG>TCG	p.P75S		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTCCTACCCGGACACCGA	0.647													0	0	0	0.01441	0	52	54										T	20647449	C	T	20647449	3	4	57	1	0	0	0	0	1	0	0	0	13332	623	22	2	225	2	RHOB	2	20647449	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	2649197	20647449	222551924	26	16503										
C2orf44	80304	broad.mit.edu	37	chr2	24254029	24254029	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cagagagaagaatccagtggGaatctgcaaataaaaataaa	9	5	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:24254029G>A	uc002rep.2	-	4	2071	c.1940C>T	c.(1939-1941)TCC>TTC	p.S647F	C2orf44_uc010eya.2_Missense_Mutation_p.P608S	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	647							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATCCAGTGGGAATCTGCAAA	0.363													0	0	0	0.001984	0	7	15										A	24254029	G	A	24254029	3	1	57	1	0	0	0	0	1	0	0	0	2168	1174	41	1	229	1	C2orf44	2	24254029	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	3606580	24254029	218945344	27	16504										
IFT172	26160	broad.mit.edu	37	chr2	27672643	27672643	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gattgcttccttgacaaggtCcagattcagatagagctctg	10	9	2	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:27672643C>A	uc002rku.2	-	37	4126	c.4075G>T	c.(4075-4077)GAC>TAC	p.D1359Y	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1359	TPR 11.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TTGACAAGGTCCAGATTCAGA	0.522													1	0	5.57489e-27	0.01441	7.31899e-27	47	44										A	27672643	C	A	27672643	3	1	57	1	0	0	0	0	1	0	0	0	7557	855	30	3	1222	3	IFT172	2	27672643	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3418614	27672643	215526730	28	16505										
FSHR	2492	broad.mit.edu	37	chr2	49189908	49189908	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgacttagagggacaagtatGtaagtggaaccactggtgac	13	6	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:49189908G>A	uc002rww.2	-	10	2126	c.2052C>T	c.(2050-2052)TAC>TAT	p.Y684Y	FSHR_uc002rwx.2_Silent_p.Y622Y|FSHR_uc010fbn.2_Silent_p.Y658Y	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	684	Cytoplasmic (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GGACAAGTATGTAAGTGGAAC	0.358									Gonadal_Dysgenesis_46_XX				0	0	0	0.003954	0	20	54										A	49189908	G	A	49189908	2	1	57	1	0	0	0	0	0	0	0	1	6073	1372	48	2		2	FSHR	2	49189908	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	21517265	49189908	194009465	29	16506										
EHBP1	23301	broad.mit.edu	37	chr2	63176182	63176182	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	taaacttggatactcatataGtagagatctagaccttgcta	7	7	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:63176182G>A	uc002sby.2	+	14	2788	c.2306G>A	c.(2305-2307)AGT>AAT	p.S769N	EHBP1_uc010fcp.2_Missense_Mutation_p.S734N|EHBP1_uc002sbz.2_Missense_Mutation_p.S734N|EHBP1_uc002scb.2_Missense_Mutation_p.S734N	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	769						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TACTCATATAGTAGAGATCTA	0.373									Hereditary_Prostate_Cancer				0	0	0	0.010504	0	20	13										A	63176182	G	A	63176182	3	1	57	1	0	0	0	0	1	0	0	0	4975	1029	36	2	2356	2	EHBP1	2	63176182	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	13986274	63176182	180023191	30	16507										
SFTPB	6439	broad.mit.edu	37	chr2	85894867	85894867	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tctgcactgcaatgcttgctCcaggctttggcaccagaact	9	13	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:85894867C>A	uc002sqh.2	-	2	136	c.130G>T	c.(130-132)GAG>TAG	p.E44*	SFTPB_uc002sqi.2_Nonsense_Mutation_p.E56*|SFTPB_uc002sqj.2_Nonsense_Mutation_p.E44*	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	44	Saposin A-type.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						AATGCTTGCTCCAGGCTTTGG	0.592													1	0	4.88482e-21	0.01441	6.13868e-21	50	35										A	85894867	C	A	85894867	4	1	57	1	0	0	0	0	0	1	0	0	14191	864	30	3	1051	3	SFTPB	2	85894867	Nonsense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	22718685	85894867	157304506	31	16508										
TBC1D8	11138	broad.mit.edu	37	chr2	101624308	101624308	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agttactcagcttaagttcaGattgtgattggtggctcatt	10	6	3	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:101624308G>A	uc010fiv.2	-	20	3529	c.3398C>T	c.(3397-3399)TCT>TTT	p.S1133F	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.S890F	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1133					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CTTAAGTTCAGATTGTGATTG	0.423													0	0	0	0.00874	0	33	142										A	101624308	G	A	101624308	3	1	57	1	0	0	0	0	1	0	0	0	15622	942	33	1	28	1	TBC1D8	2	101624308	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	15729441	101624308	141575065	32	16509										
TBC1D8	11138	broad.mit.edu	37	chr2	101624437	101624437	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	actgttcagtcagaagtgaaGctaaaatatgttcaagggag	11	5	3	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:101624437G>C	uc010fiv.2	-	20	3400	c.3269C>G	c.(3268-3270)GCT>GGT	p.A1090G	RPL31_uc010yvu.1_Intron|RPL31_uc010yvv.1_Intron|RPL31_uc010fiu.1_Intron|TBC1D8_uc002tau.3_Missense_Mutation_p.A847G	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	1090					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CAGAAGTGAAGCTAAAATATG	0.448													0	0	0	0.009096	0	4	37										C	101624437	G	C	101624437	3	2	57	1	0	0	0	0	1	0	0	0	15622	971	34	4	157	4	TBC1D8	2	101624437	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	129	101624437	141574936	33	16510										
TGFBRAP1	9392	broad.mit.edu	37	chr2	105890144	105890144	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cttggtgaaaacctgaactcCgacctgaaagaggagcgaca	11	10	0	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:105890144C>T	uc002tcq.2	-	9	1753	c.1669G>A	c.(1669-1671)GGA>AGA	p.G557R	TGFBRAP1_uc010fjc.2_Intron|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.G557R	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	557					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						ACCTGAACTCCGACCTGAAAG	0.403													0	0	0	0.00308	0	5	21										T	105890144	C	T	105890144	3	4	57	1	0	0	0	0	1	0	0	0	15821	661	23	2	929	2	TGFBRAP1	2	105890144	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	4265707	105890144	137309229	34	16511										
ATF2	1386	broad.mit.edu	37	chr2	175979453	175979453	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gaggatggtgcctgggtgatTacagtacttgaggttggtga	17	4	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:175979453T>C	uc002ujl.2	-	8	853	c.591A>G	c.(589-591)GTA>GTG	p.V197V	ATF2_uc010fqv.2_Silent_p.V148V|ATF2_uc002ujv.2_5'UTR|ATF2_uc002ujm.2_Silent_p.V139V|ATF2_uc002ujn.2_RNA|ATF2_uc002ujo.2_Intron|ATF2_uc002ujp.2_RNA|ATF2_uc002ujq.2_Silent_p.V197V|ATF2_uc002ujr.2_RNA|ATF2_uc010fqu.2_Silent_p.V179V|ATF2_uc002ujs.2_Silent_p.V139V|ATF2_uc002ujt.2_RNA|ATF2_uc002uju.2_RNA|ATF2_uc002ujw.1_Silent_p.V139V|ATF2_uc002ujx.1_RNA|ATF2_uc002ujy.1_Silent_p.V197V	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	197					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(1)|breast(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.125)			CCTGGGTGATTACAGTACTTG	0.403													0	0	0	0.01441	0	118	93										C	175979453	T	C	175979453	2	2	57	1	0	0	0	0	0	0	0	1	1080	1741	61	5		5	ATF2	2	175979453	Silent	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	70089309	175979453	67219920	35	16512										
TTN	7273	broad.mit.edu	37	chr2	179613658	179613658	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	atgaaaaggctttgtcatcaAtcttcttttgaggaggatta	9	5	4	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:179613658A>G	uc002unb.2	-	46	13693	c.13469T>C	c.(13468-13470)ATT>ACT	p.I4490T	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTCATCAATCTTCTTTTG	0.313													0	0	0	0.003954	0	23	19										G	179613658	A	G	179613658	3	3	57	1	0	0	0	0	1	0	0	0	16732	101	4	5	96828	5	TTN	2	179613658	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	3634205	179613658	63585715	36	16513										
TTN	7273	broad.mit.edu	37	chr2	179649056	179649056	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	actctttttgtaatgtggcaAtagcactaccggctattgat	8	8	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:179649056A>G	uc010zfg.1	-	16	2740	c.2516T>C	c.(2515-2517)ATT>ACT	p.I839T	TTN_uc010zfh.1_Missense_Mutation_p.I793T|TTN_uc010zfi.1_Missense_Mutation_p.I793T|TTN_uc010zfj.1_Missense_Mutation_p.I793T|TTN_uc002unb.2_Missense_Mutation_p.I839T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	839							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATGTGGCAATAGCACTACC	0.468													0	0	0	0.003271	0	27	30										G	179649056	A	G	179649056	3	3	57	1	0	0	0	0	1	0	0	0	16732	101	4	5	108860	5	TTN	2	179649056	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	35398	179649056	63550317	37	16514										
CCDC108	255101	broad.mit.edu	37	chr2	219900359	219900359	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctcctgcttctttggggagtGcatctgagtgtccatggagc	13	10	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:219900359G>A	uc002vjl.1	-	5	469	c.385C>T	c.(385-387)CAC>TAC	p.H129Y	CCDC108_uc010zkp.1_Missense_Mutation_p.H118Y|CCDC108_uc010zkq.1_Missense_Mutation_p.H64Y|CCDC108_uc002vjn.2_Missense_Mutation_p.H64Y	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	129				H -> R (in Ref. 1; BAC86878).		integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTTGGGGAGTGCATCTGAGTG	0.567													0	0	0	0.01441	0	63	16										A	219900359	G	A	219900359	3	1	57	1	0	0	0	0	1	0	0	0	2743	1319	46	2	5664	2	CCDC108	2	219900359	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	40251303	219900359	23299014	38	16515										
SCG2	7857	broad.mit.edu	37	chr2	224462395	224462395	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttgttcctcttcctgcaggtCatcttcagatgagccttgac	8	12	4	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr2:224462395C>G	uc002vnm.2	-	2	1739	c.1606G>C	c.(1606-1608)GAC>CAC	p.D536H		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	536					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCCTGCAGGTCATCTTCAGAT	0.468													0	0	0	0.014323	0	19	10										G	224462395	C	G	224462395	3	3	57	1	0	0	0	0	1	0	0	0	13891	826	29	1	251	1	SCG2	2	224462395	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	4562036	224462395	18736978	39	16516										
ZNF197	10168	broad.mit.edu	37	chr3	44685245	44685245	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	acagtggagaaaaaacctacGaatgtcatgtatgtaggaaa	10	5	1	1	rs61751651		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:44685245G>T	uc003cnm.2	+	6	2829	c.2623G>T	c.(2623-2625)GAA>TAA	p.E875*	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	875	C2H2-type 19.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AAAAACCTACGAATGTCATGT	0.383													1	0	7.33532e-06	0.003954	7.87123e-06	22	44										T	44685245	G	T	44685245	4	4	57	1	0	0	0	0	0	1	0	0	17756	1059	37	3	2641	3	ZNF197	3	44685245	Nonsense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		44685245	153337185	40	16517										
CCR1	1230	broad.mit.edu	37	chr3	46245233	46245233	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	acagcttccactctcgtaggCtttcgtgaggaaagtgaagg	12	9	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:46245233C>T	uc003cph.1	-	2	643	c.572G>A	c.(571-573)AGC>AAC	p.S191N	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	191	Extracellular (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CTCTCGTAGGCTTTCGTGAGG	0.493													0	0	0	0.014323	0	21	37										T	46245233	C	T	46245233	3	4	57	1	0	0	0	0	1	0	0	0	2939	797	28	2	499	2	CCR1	3	46245233	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1559988	46245233	151777197	41	16518										
LTF	4057	broad.mit.edu	37	chr3	46484956	46484956	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aagccccagtgtagccgtagTatctctcgttgctgttgggc	12	11	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:46484956T>C	uc003cpq.2	-	13	1669	c.1631A>G	c.(1630-1632)TAC>TGC	p.Y544C	LTF_uc003fzr.2_Missense_Mutation_p.Y500C|LTF_uc010hjh.2_Missense_Mutation_p.Y542C|LTF_uc003cpr.2_Missense_Mutation_p.Y531C	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	544	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	GTAGCCGTAGTATCTCTCGTT	0.542													0	0	0	0.01441	0	45	150										C	46484956	T	C	46484956	3	2	57	1	0	0	0	0	1	0	0	0	9079	1638	57	5	521	5	LTF	3	46484956	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	239723	46484956	151537474	42	16519										
WDR6	11180	broad.mit.edu	37	chr3	49051677	49051677	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctgtgtgtgaacttgaccagCccggccttggcccccttgtg	12	14	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:49051677C>T	uc003cvj.2	+	3	2845	c.2707C>T	c.(2707-2709)CCC>TCC	p.P903S	WDR6_uc011bby.1_Missense_Mutation_p.P351S|WDR6_uc010hkn.2_Missense_Mutation_p.P847S|WDR6_uc011bbz.1_Missense_Mutation_p.P822S	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	873	WD 13.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		ACTTGACCAGCCCGGCCTTGG	0.577											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009535	0	24	29										T	49051677	C	T	49051677	3	4	57	1	0	0	0	0	1	0	0	0	17307	739	26	2	2717	2	WDR6	3	49051677	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	2566721	49051677	148970753	43	16520										
DNAH1	25981	broad.mit.edu	37	chr3	52412779	52412779	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tccaaggcatgctcatggctGacccggccaaggtcgaggtg	14	12	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:52412779G>T	uc011bef.1	+	47	7621	c.7360G>T	c.(7360-7362)GAC>TAC	p.D2454Y		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2454					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCTCATGGCTGACCCGGCCAA	0.627													1	0	6.15735e-50	0.01441	8.31596e-50	68	62										T	52412779	G	T	52412779	3	4	57	1	0	0	0	0	1	0	0	0	4597	1290	45	3	7542	3	DNAH1	3	52412779	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	3361102	52412779	145609651	44	16521										
STAB1	23166	broad.mit.edu	37	chr3	52538860	52538860	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggtggtggacgctggccgggCaggagatcaccgtcaccttt	16	11	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:52538860C>A	uc003dej.2	+	12	1419	c.1345C>A	c.(1345-1347)CAG>AAG	p.Q449K	STAB1_uc003dei.1_Missense_Mutation_p.Q449K	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	449	Extracellular (Potential).|FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCTGGCCGGGCAGGAGATCAC	0.607													1	0	0.000673444	0.008291	0.00069412	11	32										A	52538860	C	A	52538860	3	1	57	1	0	0	0	0	1	0	0	0	15236	711	25	4	1391	4	STAB1	3	52538860	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	126081	52538860	145483570	45	16522										
ARHGAP31	57514	broad.mit.edu	37	chr3	119120886	119120886	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctcaggcccggcccccaccGgaacagctgaaggttttccg	12	16	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:119120886G>A	uc003ecj.3	+	10	1819	c.1287G>A	c.(1285-1287)CCG>CCA	p.P429P		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	429					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						GGCCCCCACCGGAACAGCTGA	0.617													0	0	0	0.003163	0	15	46										A	119120886	G	A	119120886	2	1	57	1	0	0	0	0	0	0	0	1	880	1103	39	2		2	ARHGAP31	3	119120886	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	66582026	119120886	78901544	46	16523										
EPHB1	2047	broad.mit.edu	37	chr3	134968233	134968233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	acttcacggcctttaccaccGtggatgactggctcagcgcc	10	15	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:134968233G>A	uc003eqt.2	+	15	2966	c.2746G>A	c.(2746-2748)GTG>ATG	p.V916M	EPHB1_uc003equ.2_Missense_Mutation_p.V477M	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	916	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CTTTACCACCGTGGATGACTG	0.587													0	0	0	0.009718	0	41	33										A	134968233	G	A	134968233	3	1	57	1	0	0	0	0	1	0	0	0	5174	1145	40	2	2804	2	EPHB1	3	134968233	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	15847347	134968233	63054197	47	16524										
TBCCD1	55171	broad.mit.edu	37	chr3	186276258	186276258	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	caggagactgagatttgtttCtgggactgggccactcttcg	13	9	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:186276258C>T	uc003fqg.2	-	3	569	c.440G>A	c.(439-441)AGA>AAA	p.R147K	TBCCD1_uc011bry.1_Missense_Mutation_p.R147K|TBCCD1_uc003fqh.2_Missense_Mutation_p.R51K	NM_018138	NP_060608	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	147					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			large_intestine(1)|ovary(1)	2	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		AGATTTGTTTCTGGGACTGGG	0.408													0	0	0	0.014323	0	19	81										T	186276258	C	T	186276258	3	4	57	1	0	0	0	0	1	0	0	0	15629	913	32	1	1253	1	TBCCD1	3	186276258	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	51308025	186276258	11746172	48	16525										
TP63	8626	broad.mit.edu	37	chr3	189586386	189586386	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tagtgggcaagtcctgggccGacgctgctttgaggcccgga	16	11	0	1	rs113993967		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:189586386G>A	uc003fry.2	+	8	1099	c.1010G>A	c.(1009-1011)CGA>CAA	p.R337Q	TP63_uc003frx.2_Missense_Mutation_p.R337Q|TP63_uc003frz.2_Missense_Mutation_p.R337Q|TP63_uc010hzc.1_Missense_Mutation_p.R337Q|TP63_uc003fsa.2_Missense_Mutation_p.R243Q|TP63_uc003fsb.2_Missense_Mutation_p.R243Q|TP63_uc003fsc.2_Missense_Mutation_p.R243Q|TP63_uc003fsd.2_Missense_Mutation_p.R243Q|TP63_uc010hzd.1_Missense_Mutation_p.R158Q|TP63_uc003fse.1_Missense_Mutation_p.R218Q	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	337					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTCCTGGGCCGACGCTGCTTT	0.483									Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.001984	0	6	17										A	189586386	G	A	189586386	3	1	57	1	0	0	0	0	1	0	0	0	16389	1058	37	1	1086	1	TP63	3	189586386	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	3310128	189586386	8436044	49	16526										
IL1RAP	3556	broad.mit.edu	37	chr3	190366314	190366314	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctgtgaaggaaacgaaggtGaaagagctgaagagggctaa	16	4	0	5			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr3:190366314G>A	uc003fsm.1	+	12	1739	c.1533G>A	c.(1531-1533)GTG>GTA	p.V511V	IL1RAP_uc010hzg.1_Silent_p.V511V|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.V511V|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Intron	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	511	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		AAACGAAGGTGAAAGAGCTGA	0.502													0	0	0	0.006122	0	15	68										A	190366314	G	A	190366314	2	1	57	1	0	0	0	0	0	0	0	1	7660	1277	45	1		1	IL1RAP	3	190366314	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	779928	190366314	7656116	50	16527										
TMEM175	84286	broad.mit.edu	37	chr4	951684	951684	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctcgtggccgccctgagtgcGaccgggccgcgcttcctggc	15	17	0	1	rs141810982	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:951684G>T	uc003gbq.2	+	11	1013	c.915G>T	c.(913-915)GCG>GCT	p.A305A	TMEM175_uc003gbr.2_Silent_p.A223A|TMEM175_uc003gbu.2_Silent_p.A223A|TMEM175_uc003gbs.2_Silent_p.A188A|TMEM175_uc003gbt.2_Silent_p.A188A|TMEM175_uc003gbv.2_Silent_p.A188A|TMEM175_uc010ibm.2_Silent_p.A121A	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	305						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCCTGAGTGCGACCGGGCCGC	0.622													1	0	2.43468e-25	0.01441	3.16105e-25	46	47										T	951684	G	T	951684	2	4	57	1	0	0	0	0	0	0	0	1	16088	1045	37	3		3	TMEM175	4	951684	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		951684	190202592	51	16528										
WHSC1	7468	broad.mit.edu	37	chr4	1936889	1936889	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aggtaatgtaaatgggaaaaAaagaaaccacacaaagagga	10	4	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:1936889A>G	uc003gdz.3	+	7	1750	c.1574A>G	c.(1573-1575)AAA>AGA	p.K525R	WHSC1_uc003geb.3_Missense_Mutation_p.K525R|WHSC1_uc003gec.3_Missense_Mutation_p.K525R|WHSC1_uc003ged.3_Missense_Mutation_p.K525R|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdy.1_Missense_Mutation_p.K525R|WHSC1_uc010icd.1_Missense_Mutation_p.K525R|WHSC1_uc003gea.1_Missense_Mutation_p.K525R|WHSC1_uc010ice.1_Missense_Mutation_p.K525R|WHSC1_uc003geh.1_Missense_Mutation_p.K525R	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	525					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AATGGGAAAAAAAGAAACCAC	0.468			T	IGH@	MM								0	0	0	0.001168	0	6	19										G	1936889	A	G	1936889	3	3	57	1	0	0	0	0	1	0	0	0	17359	14	1	5	1596	5	WHSC1	4	1936889	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	985205	1936889	189217387	52	16529										
C4orf14	84273	broad.mit.edu	37	chr4	57842717	57842717	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gatttgccggcgttggtggcGcccactaagtagacgtcccc	13	13	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:57842717G>T	uc003hck.2	-	1	1110	c.1035C>A	c.(1033-1035)GGC>GGA	p.G345G	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	345							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					CGTTGGTGGCGCCCACTAAGT	0.607													1	0	1.52009e-12	0.003163	1.77722e-12	14	40										T	57842717	G	T	57842717	2	4	57	1	0	0	0	0	0	0	0	1	2251	1074	38	4		4	C4orf14	4	57842717	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	55905828	57842717	133311559	53	16530										
BANK1	55024	broad.mit.edu	37	chr4	102946511	102946511	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agaggttggcagtgagagttCtgaagaccagtatgatgact	14	5	1	6			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:102946511C>G	uc003hvy.3	+	9	1713	c.1439C>G	c.(1438-1440)TCT>TGT	p.S480C	BANK1_uc003hvx.3_Missense_Mutation_p.S465C|BANK1_uc010ill.2_Missense_Mutation_p.S347C|BANK1_uc003hvz.3_Missense_Mutation_p.S450C	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	480					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGTGAGAGTTCTGAAGACCAG	0.493													0	0	0	0.00499	0	14	56										G	102946511	C	G	102946511	3	3	57	1	0	0	0	0	1	0	0	0	1309	913	32	1	1473	1	BANK1	4	102946511	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	45103794	102946511	88207765	54	16531										
ANK2	287	broad.mit.edu	37	chr4	114278218	114278218	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	taaagaatcattagctctccAaggcactcatgaaaaagaca	6	9	3	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:114278218A>G	uc003ibe.3	+	38	8544	c.8444A>G	c.(8443-8445)CAA>CGA	p.Q2815R	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.Q117R|ANK2_uc011cgb.1_Missense_Mutation_p.Q2830R	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2782					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTAGCTCTCCAAGGCACTCAT	0.463													0	0	0	0.010818	0	30	36										G	114278218	A	G	114278218	3	3	57	1	0	0	0	0	1	0	0	0	621	130	5	5	8659	5	ANK2	4	114278218	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	11331707	114278218	76876058	55	16532										
GUCY1A3	2982	broad.mit.edu	37	chr4	156631721	156631721	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agtggaggttatcaaagaatCtcttggtgaagaggttttta	12	3	2	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:156631721C>T	uc003iov.2	+	7	940	c.404C>T	c.(403-405)TCT>TTT	p.S135F	GUCY1A3_uc003iou.2_Missense_Mutation_p.S135F|GUCY1A3_uc010iqc.2_Missense_Mutation_p.S135F|GUCY1A3_uc003iow.2_Missense_Mutation_p.S135F|GUCY1A3_uc010iqd.2_Missense_Mutation_p.S134F|GUCY1A3_uc003iox.2_Missense_Mutation_p.S135F|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.S135F|GUCY1A3_uc010iqe.2_Intron|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.S135F	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	135				VIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLK QSSHCQEAGKRGR -> LSKNLLVKRFLKYVTRKMKTSLGW LEAPLKIFKQLQYPSETEQPLPRSRKKGQ (in Ref. 1).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		ATCAAAGAATCTCTTGGTGAA	0.383													0	0	0	0.005524	0	30	25										T	156631721	C	T	156631721	3	4	57	1	0	0	0	0	1	0	0	0	6894	913	32	1	418	1	GUCY1A3	4	156631721	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	42353503	156631721	34522555	56	16533										
AADAT	51166	broad.mit.edu	37	chr4	170988519	170988519	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccttcttctccccattcgtgTagaagctgtgatatcatgag	8	11	3	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:170988519T>C	uc003isr.2	-	9	1263	c.921A>G	c.(919-921)CTA>CTG	p.L307L	AADAT_uc003iss.2_Silent_p.L307L|AADAT_uc003ist.2_Silent_p.L311L	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II	307					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCCATTCGTGTAGAAGCTGTG	0.343													0	0	0	0.012213	0	25	31										C	170988519	T	C	170988519	2	2	57	1	0	0	0	0	0	0	0	1	14	1625	57	5		5	AADAT	4	170988519	Silent	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	14356798	170988519	20165757	57	16534										
FAT1	2195	broad.mit.edu	37	chr4	187525600	187525600	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gatgtcaggaggactccttgCgggttaacttcaaaagcctt	11	9	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr4:187525600C>A	uc003izf.2	-	18	10667	c.10479G>T	c.(10477-10479)CCG>CCT	p.P3493P		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3493	Extracellular (Potential).|Cadherin 32.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGACTCCTTGCGGGTTAACTT	0.433										HNSCC(5;0.00058)			1	0	1.3612e-06	0.003163	1.49478e-06	12	31										A	187525600	C	A	187525600	2	1	57	1	0	0	0	0	0	0	0	1	5689	755	27	4		4	FAT1	4	187525600	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	16537081	187525600	3628676	58	16535										
LRRC14B	389257	broad.mit.edu	37	chr5	192543	192543	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctgaccgggaagatcccgaCgctgcttgggtgagtcttgg	16	10	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:192543C>A	uc003jal.1	+	1	918	c.890C>A	c.(889-891)ACG>AAG	p.T297K		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	297	LRR 1.									skin(1)	1						AAGATCCCGACGCTGCTTGGG	0.657													1	0	0.000602214	0.000602	0.000623438	3	4										A	192543	C	A	192543	3	1	57	1	0	0	0	0	1	0	0	0	8969	536	19	4	892	4	LRRC14B	5	192543	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		192543	180722717	59	16536										
TERT	7015	broad.mit.edu	37	chr5	1294371	1294371	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggcaggcccagggggaccccGgcctccctgacgctatggtt	15	15	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:1294371G>A	uc003jcb.1	-	2	688	c.630C>T	c.(628-630)GCC>GCT	p.A210A	TERT_uc003jca.1_Silent_p.A210A|TERT_uc003jcc.1_Silent_p.A210A|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	210	RNA-interacting domain 1.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGGGGACCCCGGCCTCCCTGA	0.746									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				0	0	0	0.009096	0	4	1										A	1294371	G	A	1294371	2	1	57	1	0	0	0	0	0	0	0	1	15761	1103	39	2		2	TERT	5	1294371	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1101828	1294371	179620889	60	16537										
PDZD2	23037	broad.mit.edu	37	chr5	32059421	32059421	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cctggcatctacattcacagCcttgctccaggatcagtggc	9	14	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:32059421C>G	uc003jhl.2	+	13	2665	c.2277C>G	c.(2275-2277)AGC>AGG	p.S759R	PDZD2_uc003jhm.2_Missense_Mutation_p.S759R|PDZD2_uc011cnx.1_Missense_Mutation_p.S585R	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	759	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						ACATTCACAGCCTTGCTCCAG	0.468													0	0	0	0.007413	0	16	15										G	32059421	C	G	32059421	3	3	57	1	0	0	0	0	1	0	0	0	11701	738	26	4	2323	4	PDZD2	5	32059421	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	30765050	32059421	148855839	61	16538										
MGC42105	167359	broad.mit.edu	37	chr5	43245942	43245942	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctatgcccggtgggatcggcGcgacagtgtagaaagtggct	16	9	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:43245942G>A	uc003jno.2	+	2	946	c.65G>A	c.(64-66)CGC>CAC	p.R22H		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	22							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						TGGGATCGGCGCGACAGTGTA	0.597													0	0	0	0.01441	0	75	57										A	43245942	G	A	43245942	3	1	57	1	0	0	0	0	1	0	0	0	9552	1087	38	2	67	2	MGC42105	5	43245942	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	11186521	43245942	137669318	62	16539										
RGS7BP	401190	broad.mit.edu	37	chr5	63871635	63871635	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agatccatccagaaatctgtCggctttacatccagctgcag	8	12	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:63871635C>T	uc003jtj.2	+	3	367	c.367C>T	c.(367-369)CGG>TGG	p.R123W	RGS7BP_uc011cqu.1_5'UTR	NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding	123					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane					0		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		AGAAATCTGTCGGCTTTACAT	0.433													0	0	0	0.007291	0	25	13										T	63871635	C	T	63871635	3	4	57	1	0	0	0	0	1	0	0	0	13311	875	31	1	377	1	RGS7BP	5	63871635	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	20625693	63871635	117043625	63	16540										
KDM3B	51780	broad.mit.edu	37	chr5	137722024	137722028	+	Frame_Shift_Del	DEL	GGACT	GGACT	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttacaccaaagaaaacggcaGgactctggtggtgcaggatg							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:137722024_137722028delGGACT	uc003lcy.1	+	7	1294_1298	c.1094_1098delGGACT	c.(1093-1098)AGGACTfs	p.R365fs	KDM3B_uc010jew.1_Frame_Shift_Del_p.R21fs|KDM3B_uc011cys.1_5'UTR	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	365_366					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						GAAAACGGCAGGACTCTGGTGGTGC	0.551																		64	150	---	---								-	137722028	GGACT	-	137722024	7	5	57	1	0	1	0	1	0	0	0	0	8127	1000	35	0	1120	0	KDM3B	5	137722024	Frame_Shift_Del	DEL	GGACT	TCGA-DK-A3IL-01A-11D-A20D-08	73850389	137722024	43193236	64	16541										
PCDHA11	56138	broad.mit.edu	37	chr5	140250447	140250447	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	taccgcggtcggtgggtgcgGgccacgtggtggcgaaggtg	21	9	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:140250447G>T	uc003lia.2	+	1	2617	c.1759G>T	c.(1759-1761)GGC>TGC	p.G587C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.G587C	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	587	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGGTGCGGGCCACGTGGT	0.677													1	0	1.13719e-10	0.008361	1.30361e-10	22	95										T	140250447	G	T	140250447	3	4	57	1	0	0	0	0	1	0	0	0	11521	1232	43	4	1761	4	PCDHA11	5	140250447	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	2528423	140250447	40664813	65	16542										
PCDH1	5097	broad.mit.edu	37	chr5	141233975	141233975	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccgggtacatgtgcctgtcaTggcgacatcaggcaaagggc	14	11	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:141233975T>C	uc003llp.2	-	5	3463	c.3346A>G	c.(3346-3348)ATG>GTG	p.M1116V		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTGCCTGTCATGGCGACATCA	0.592													0	0	0	0.00245	0	10	39										C	141233975	T	C	141233975	3	2	57	1	0	0	0	0	1	0	0	0	11506	1464	51	5	371	5	PCDH1	5	141233975	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	983528	141233975	39681285	66	16543										
GABRG2	2566	broad.mit.edu	37	chr5	161569191	161569191	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agattatgtggtcatgtctgTctactttgatctgagcagaa	10	6	4	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:161569191T>C	uc003lyz.3	+	7	1149	c.791T>C	c.(790-792)GTC>GCC	p.V264A	GABRG2_uc010jjc.2_Missense_Mutation_p.V304A|GABRG2_uc003lyy.3_Missense_Mutation_p.V264A|GABRG2_uc011dej.1_Missense_Mutation_p.V169A	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	264	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GTCATGTCTGTCTACTTTGAT	0.403													0	0	0	0.009535	0	24	144										C	161569191	T	C	161569191	3	2	57	1	0	0	0	0	1	0	0	0	6172	1667	58	5	941	5	GABRG2	5	161569191	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	20335216	161569191	19346069	67	16544										
RUFY1	80230	broad.mit.edu	37	chr5	178977642	178977642	+	Frame_Shift_Del	DEL	G	G	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccggagctggagccggggccGgggcccgggtcagcgcttga							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr5:178977642delG	uc003mka.1	+	1	72	c.72delG	c.(70-72)CCGfs	p.P24fs		NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	24					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			agccggggccggggcCCGGGT	0.512										HNSCC(44;0.11)								2	4	---	---								-	178977642	G	-	178977642	7	5	57	1	0	1	0	1	0	0	0	0	13738	1103	39	0	74	0	RUFY1	5	178977642	Frame_Shift_Del	DEL	G	TCGA-DK-A3IL-01A-11D-A20D-08	17408451	178977642	1937618	68	16545										
GABBR1	2550	broad.mit.edu	37	chr6	29598366	29598366	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gagctgggaggtccccacccGtcaggaaaaccttcccattt	10	14	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:29598366G>A	uc003nmt.3	-	4	680	c.344C>T	c.(343-345)ACG>ATG	p.T115M	GABBR1_uc003nmp.3_5'Flank|GABBR1_uc003nms.3_5'Flank|GABBR1_uc003nmu.3_Intron|GABBR1_uc011dlr.1_Translation_Start_Site|GABBR1_uc011dls.1_Missense_Mutation_p.T115M	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	115	Extracellular (Potential).|Sushi 2.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.T115M(1)		ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	GTCCCCACCCGTCAGGAAAAC	0.562													0	0	0	0.00499	0	14	33										A	29598366	G	A	29598366	3	1	57	1	0	0	0	0	1	0	0	0	6155	1145	40	2	2766	2	GABBR1	6	29598366	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		29598366	141516701	69	16546										
SLC29A1	2030	broad.mit.edu	37	chr6	44197137	44197137	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tccattgcagatacaaagctGtctggcttatcttcttcatg	7	10	4	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:44197137G>C	uc003owu.1	+	3	369	c.40G>C	c.(40-42)GTC>CTC	p.V14L	SLC29A1_uc011dvp.1_Missense_Mutation_p.V33L|SLC29A1_uc003owv.1_Missense_Mutation_p.V14L|SLC29A1_uc003oww.1_Missense_Mutation_p.V93L|SLC29A1_uc011dvq.1_Missense_Mutation_p.V56L|SLC29A1_uc003owx.1_Missense_Mutation_p.V14L|SLC29A1_uc003owy.1_Missense_Mutation_p.V14L|SLC29A1_uc003owz.1_Missense_Mutation_p.V14L	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	14	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	ATACAAAGCTGTCTGGCTTAT	0.562													0	0	0	0.009718	0	34	17										C	44197137	G	C	44197137	3	2	57	1	0	0	0	0	1	0	0	0	14534	1377	48	4	46	4	SLC29A1	6	44197137	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	14598771	44197137	126917930	70	16547										
CDC5L	988	broad.mit.edu	37	chr6	44361233	44361233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggaaacaacagatgatccacGaaaacttaaacctggagaaa	8	8	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:44361233G>A	uc003oxl.2	+	4	621	c.362G>A	c.(361-363)CGA>CAA	p.R121Q		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	121					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GATGATCCACGAAAACTTAAA	0.408													0	0	0	0.00308	0	7	18										A	44361233	G	A	44361233	3	1	57	1	0	0	0	0	1	0	0	0	3082	1058	37	1	376	1	CDC5L	6	44361233	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	164096	44361233	126753834	71	16548										
MDN1	23195	broad.mit.edu	37	chr6	90359913	90359913	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcgtttcccagttcgatagtCtcctctatttattcaaatgg	6	10	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:90359913C>G	uc003pnn.1	-	97	16152	c.16036G>C	c.(16036-16038)GAC>CAC	p.D5346H		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5346					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTTCGATAGTCTCCTCTATTT	0.348													0	0	0	0.003163	0	12	1										G	90359913	C	G	90359913	3	3	57	1	0	0	0	0	1	0	0	0	9415	913	32	1	778	1	MDN1	6	90359913	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	45998680	90359913	80755154	72	16549										
WISP3	8838	broad.mit.edu	37	chr6	112382385	112382385	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgctgtaaaatctgtgccaaGcaaccaggggaaatctgcaa	10	9	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:112382385G>T	uc003pvm.2	+	3	350	c.240G>T	c.(238-240)AAG>AAT	p.K80N	WISP3_uc003pvn.2_RNA|WISP3_uc003pvo.2_Missense_Mutation_p.K98N	NM_003880	NP_003871	O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	80	IGFBP N-terminal.				cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding				0		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TCTGTGCCAAGCAACCAGGGG	0.537													1	0	6.4685e-43	0.01441	8.53987e-43	54	21										T	112382385	G	T	112382385	3	4	57	1	0	0	0	0	1	0	0	0	17371	962	34	4	300	4	WISP3	6	112382385	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	22022472	112382385	58732682	73	16550										
GPRC6A	222545	broad.mit.edu	37	chr6	117128326	117128326	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tccgtaaaaatgaaggaaagCgaattttgtcactcaggatt	9	6	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:117128326C>T	uc003pxj.1	-	3	564	c.542G>A	c.(541-543)CGC>CAC	p.R181H	GPRC6A_uc003pxk.1_Missense_Mutation_p.R181H|GPRC6A_uc003pxl.1_Missense_Mutation_p.R181H	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	181	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGAAGGAAAGCGAATTTTGTC	0.398													0	0	0	0.01441	0	44	26										T	117128326	C	T	117128326	3	4	57	1	0	0	0	0	1	0	0	0	6728	768	27	2	2254	2	GPRC6A	6	117128326	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	4745941	117128326	53986741	74	16551										
CCDC28A	25901	broad.mit.edu	37	chr6	139097341	139097341	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtcaatgccaaaaaaaatgcCattccagtgagtaaaagcac	7	9	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:139097341C>A	uc003qie.2	+	2	509	c.354C>A	c.(352-354)GCC>GCA	p.A118A	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	118											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		AAAAAAATGCCATTCCAGTGA	0.388													1	0	2.77807e-22	0.013114	3.58707e-22	40	10										A	139097341	C	A	139097341	2	1	57	1	0	0	0	0	0	0	0	1	2802	581	21	4		4	CCDC28A	6	139097341	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	21969015	139097341	32017726	75	16552										
SYNE1	23345	broad.mit.edu	37	chr6	152464820	152464820	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tttgctgcgaatgatattttCggtttgctgtatctgaaaac	9	6	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr6:152464820C>T	uc010kiw.2	-	138	25659	c.25057G>A	c.(25057-25059)GAA>AAA	p.E8353K	SYNE1_uc010kiv.2_Missense_Mutation_p.E2877K|SYNE1_uc003qos.3_Missense_Mutation_p.E2877K|SYNE1_uc003qot.3_Missense_Mutation_p.E8305K|SYNE1_uc003qou.3_Missense_Mutation_p.E8353K|SYNE1_uc003qop.3_Missense_Mutation_p.E538K|SYNE1_uc011eez.1_Missense_Mutation_p.E555K|SYNE1_uc003qoq.3_Missense_Mutation_p.E555K|SYNE1_uc003qor.3_Missense_Mutation_p.E1276K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8353	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGATATTTTCGGTTTGCTGT	0.532										HNSCC(10;0.0054)			0	0	0	0.012319	0	19	52										T	152464820	C	T	152464820	3	4	57	1	0	0	0	0	1	0	0	0	15442	893	31	1	1372	1	SYNE1	6	152464820	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	13367479	152464820	18650247	76	16553										
MACC1	346389	broad.mit.edu	37	chr7	20199459	20199459	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	caagccattttataagcctcCcgatcatttttaagccactc	4	13	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:20199459C>T	uc003sus.3	-	5	834	c.525G>A	c.(523-525)CGG>CGA	p.R175R	MACC1_uc010kug.2_Silent_p.R175R	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	175					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TATAAGCCTCCCGATCATTTT	0.468													0	0	0	0.004482	0	8	68										T	20199459	C	T	20199459	2	4	57	1	0	0	0	0	0	0	0	1	9143	610	22	2		2	MACC1	7	20199459	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		20199459	138939204	77	16554										
DNAH11	8701	broad.mit.edu	37	chr7	21631013	21631013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agttggagcacagagttgagCgcacacagaaaaacgtgaag	13	7	0	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:21631013C>T	uc003svc.2	+	14	2516	c.2485C>T	c.(2485-2487)CGC>TGC	p.R829C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	829	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CAGAGTTGAGCGCACACAGAA	0.607									Kartagener_syndrome				0	0	0	0.00499	0	14	33										T	21631013	C	T	21631013	3	4	57	1	0	0	0	0	1	0	0	0	4599	768	27	2	2539	2	DNAH11	7	21631013	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1431554	21631013	137507650	78	16555										
C7orf30	115416	broad.mit.edu	37	chr7	23347511	23347511	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aacacctgaaatgtaaacgtGaccctcatgttaagatagaa	7	8	1	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:23347511G>T	uc003swd.1	+	3	492	c.460G>T	c.(460-462)GAC>TAC	p.D154Y	C7orf30_uc003swe.2_5'Flank	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	154						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			ATGTAAACGTGACCCTCATGT	0.428													1	0	9.68594e-22	0.01441	1.23038e-21	49	81										T	23347511	G	T	23347511	3	4	57	1	0	0	0	0	1	0	0	0	2386	1290	45	3	470	3	C7orf30	7	23347511	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1716498	23347511	135791152	79	16556										
MUC17	140453	broad.mit.edu	37	chr7	100678782	100678782	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	catcctttcaacaactcctgTtgacaacagcacacctgtga	5	14	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:100678782T>C	uc003uxp.1	+	3	4138	c.4085T>C	c.(4084-4086)GTT>GCT	p.V1362A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1362	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAACTCCTGTTGACAACAGC	0.453													0	0	0	0.01441	0	169	238										C	100678782	T	C	100678782	3	2	57	1	0	0	0	0	1	0	0	0	9974	1725	60	5	4095	5	MUC17	7	100678782	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	77331271	100678782	58459881	80	16557										
SYPL1	6856	broad.mit.edu	37	chr7	105732326	105732326	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gatggactgtgtaggctggtCtccttgtacacaaaccaagc	11	10	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:105732326C>A	uc003vdp.2	-	6	787	c.705G>T	c.(703-705)GAG>GAT	p.E235D	SYPL1_uc003vdo.2_Missense_Mutation_p.E217D	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	235	Cytoplasmic (Potential).|MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						GTAGGCTGGTCTCCTTGTACA	0.383													1	0	2.38262e-10	0.010771	2.69191e-10	35	39										A	105732326	C	A	105732326	3	1	57	1	0	0	0	0	1	0	0	0	15459	912	32	3	78	3	SYPL1	7	105732326	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	5053544	105732326	53406337	81	16558										
FLNC	2318	broad.mit.edu	37	chr7	128471003	128471003	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gagaacgtgtccgtggccctCgagttcctcgagcgcgagca	14	13	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:128471003C>G	uc003vnz.3	+	1	521	c.312C>G	c.(310-312)CTC>CTG	p.L104L	FLNC_uc003voa.3_Silent_p.L104L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	104	CH 1.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CCGTGGCCCTCGAGTTCCTCG	0.657													0	0	0	0.007835	0	32	37										G	128471003	C	G	128471003	2	3	57	1	0	0	0	0	0	0	0	1	5935	871	31	1		1	FLNC	7	128471003	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	22738677	128471003	30667660	82	16559										
DGKI	9162	broad.mit.edu	37	chr7	137271869	137271869	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccagttgagagttcgagccaGgtcattcccagtccccagag	11	13	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr7:137271869G>T	uc003vtt.2	-	13	1400	c.1399C>A	c.(1399-1401)CTG>ATG	p.L467M	DGKI_uc003vtu.2_Missense_Mutation_p.L167M	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	467	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GTTCGAGCCAGGTCATTCCCA	0.552													1	0	7.7325e-45	0.01441	1.03246e-44	46	81										T	137271869	G	T	137271869	3	4	57	1	0	0	0	0	1	0	0	0	4471	991	35	4	1886	4	DGKI	7	137271869	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	8800866	137271869	21866794	83	16560										
RP1L1	94137	broad.mit.edu	37	chr8	10469938	10469938	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aggtctcggcccttgccttgCctggacagccctggggccgc	14	16	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:10469938C>T	uc003wtc.2	-	4	1899	c.1670G>A	c.(1669-1671)GGC>GAC	p.G557D		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	557					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCTTGCCTTGCCTGGACAGCC	0.657													0	0	0	0.004656	0	24	39										T	10469938	C	T	10469938	3	4	57	1	0	0	0	0	1	0	0	0	13533	739	26	2	5536	2	RP1L1	8	10469938	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		10469938	135894084	84	16561										
GATA4	2626	broad.mit.edu	37	chr8	11615912	11615912	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cccgtcagccagtctccacaGaccagctccaagcaggactc	8	18	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:11615912G>A	uc003wuc.2	+	7	1811	c.1257G>A	c.(1255-1257)CAG>CAA	p.Q419Q	GATA4_uc003wub.1_Silent_p.Q213Q|GATA4_uc011kxc.1_Silent_p.Q420Q|uc003wud.1_5'Flank	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	419					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		AGTCTCCACAGACCAGCTCCA	0.587													0	0	0	0.013726	0	27	47										A	11615912	G	A	11615912	2	1	57	1	0	0	0	0	0	0	0	1	6256	933	33	1		1	GATA4	8	11615912	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1145974	11615912	134748110	85	16562										
TNFRSF10D	8793	broad.mit.edu	37	chr8	23004489	23004489	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cttaccctgttctacacgtcCggcacatctcaggggagttt	9	13	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:23004489C>T	uc003xcz.1	-	4	559	c.467G>A	c.(466-468)CGG>CAG	p.R156Q		NM_003840	NP_003831	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily,	156	Extracellular (Potential).|TNFR-Cys 3.				anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TCTACACGTCCGGCACATCTC	0.502													0	0	0	0.006214	0	7	44										T	23004489	C	T	23004489	3	4	57	1	0	0	0	0	1	0	0	0	16280	652	23	2	717	2	TNFRSF10D	8	23004489	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	11388577	23004489	123359533	86	16563										
ADAM32	203102	broad.mit.edu	37	chr8	39111966	39111966	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gaaacaagtgccattgttcgCcaggctataagcctccaaac	8	12	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:39111966C>A	uc003xmt.3	+	18	2181	c.1936C>A	c.(1936-1938)CCA>ACA	p.P646T	ADAM32_uc011lch.1_Missense_Mutation_p.P547T|ADAM32_uc003xmu.3_Missense_Mutation_p.P540T|ADAM32_uc003xmv.2_Missense_Mutation_p.P70T	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	646	EGF-like.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			CCATTGTTCGCCAGGCTATAA	0.363													1	0	0.00621372	0.006214	0.00637652	6	3										A	39111966	C	A	39111966	3	1	57	1	0	0	0	0	1	0	0	0	249	739	26	4	2006	4	ADAM32	8	39111966	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	16107477	39111966	107252056	87	16564										
PLAT	5327	broad.mit.edu	37	chr8	42050684	42050684	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcagcagcacacagcagagcCctctcttcattgcatccatg	8	15	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:42050684C>G	uc003xos.2	-	2	229	c.20G>C	c.(19-21)GGG>GCG	p.G7A	PLAT_uc010lxf.1_Missense_Mutation_p.G7A|PLAT_uc010lxg.1_Missense_Mutation_p.G7A|PLAT_uc003xot.2_Missense_Mutation_p.G7A|PLAT_uc011lcm.1_Missense_Mutation_p.G7A|PLAT_uc011lcn.1_Missense_Mutation_p.G7A	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	7					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACAGCAGAGCCCTCTCTTCAT	0.547													0	0	0	0.003163	0	12	28										G	42050684	C	G	42050684	3	3	57	1	0	0	0	0	1	0	0	0	12021	623	22	4	1720	4	PLAT	8	42050684	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	2938718	42050684	104313338	88	16565										
ZFHX4	79776	broad.mit.edu	37	chr8	77764038	77764038	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctagggctgcaaagctggaGcccagtggtcatgtggctgg	17	9	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:77764038G>T	uc003yav.2	+	10	5133	c.4746G>T	c.(4744-4746)GAG>GAT	p.E1582D	ZFHX4_uc003yau.1_Missense_Mutation_p.E1627D|ZFHX4_uc003yaw.1_Missense_Mutation_p.E1582D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1582						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAAAGCTGGAGCCCAGTGGTC	0.517										HNSCC(33;0.089)			1	0	1.67942e-08	0.006122	1.87935e-08	15	20										T	77764038	G	T	77764038	3	4	57	1	0	0	0	0	1	0	0	0	17632	962	34	4	4915	4	ZFHX4	8	77764038	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	35713354	77764038	68599984	89	16566										
GDF6	392255	broad.mit.edu	37	chr8	97157110	97157111	+	Frame_Shift_Ins	INS	-	-	A													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cttgctgcagcgtagcctggINSacttcttgccgtgccgcttg							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:97157110_97157111insA	uc003yhp.2	-	2	1148_1149	c.1048_1049insT	c.(1048-1050)TCCfs	p.S350fs		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	350					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GCGTAGCCTGGACTTCTTGCCG	0.515																		8	13	---	---								A	97157111	-	A	97157110	7	5	57	1	0	1	1	0	0	0	0	0	6317	1174	41	0	322	0	GDF6	8	97157110	Frame_Shift_Ins	INS	-	TCGA-DK-A3IL-01A-11D-A20D-08	19393072	97157110	49206912	90	16567										
FAM83H	286077	broad.mit.edu	37	chr8	144810312	144810312	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggctggtctggaagcggaagTcgtcgccgtggctgaggaac	18	9	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr8:144810312T>G	uc003yzk.2	-	5	1388	c.1319A>C	c.(1318-1320)GAC>GCC	p.D440A	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	440					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAAGCGGAAGTCGTCGCCGTG	0.697													0	0	0	0.000602	0	5	15										G	144810312	T	G	144810312	3	3	57	1	0	0	0	0	1	0	0	0	5640	1667	58	5	2224	5	FAM83H	8	144810312	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	47653202	144810312	1553710	91	16568										
CNTLN	54875	broad.mit.edu	37	chr9	17466040	17466040	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aattgattcactaaagcaaaGacttaacgttgctgtaaaag	7	6	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:17466040G>T	uc003zmz.2	+	22	3616	c.3590G>T	c.(3589-3591)AGA>ATA	p.R1197I	CNTLN_uc003zmy.2_Missense_Mutation_p.R1198I|CNTLN_uc010mio.2_Missense_Mutation_p.R877I	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1198	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		CTAAAGCAAAGACTTAACGTT	0.303													1	0	4.74835e-14	0.010818	5.63567e-14	27	27										T	17466040	G	T	17466040	3	4	57	1	0	0	0	0	1	0	0	0	3639	942	33	3	3709	3	CNTLN	9	17466040	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		17466040	123747391	92	16569										
NTRK2	4915	broad.mit.edu	37	chr9	87356831	87356837	+	Frame_Shift_Del	DEL	TAATTTA	TAATTTA	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aaacccaaattatcctgatgTaatttatgaaggtagctatc							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:87356831_87356837delTAATTTA	uc004aoa.1	+	12	2122_2128	c.1184_1190delTAATTTA	c.(1183-1191)GTAATTTATfs	p.V395fs	NTRK2_uc004anv.1_Frame_Shift_Del_p.V382fs|NTRK2_uc004any.1_Frame_Shift_Del_p.V395fs|NTRK2_uc004anz.1_Frame_Shift_Del_p.V395fs|NTRK2_uc011lsz.1_Frame_Shift_Del_p.V395fs|NTRK2_uc011lta.1_Frame_Shift_Del_p.V395fs|NTRK2_uc004aob.1_Frame_Shift_Del_p.V395fs|NTRK2_uc011ltb.1_Frame_Shift_Del_p.V239fs	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	395_397	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TATCCTGATGTAATTTATGAAGGTAGC	0.309										TSP Lung(25;0.17)								7	19	---	---								-	87356837	TAATTTA	-	87356831	7	5	57	1	0	1	0	1	0	0	0	0	10707	1638	57	0	1218	0	NTRK2	9	87356831	Frame_Shift_Del	DEL	TAATTTA	TCGA-DK-A3IL-01A-11D-A20D-08	69890791	87356831	53856600	93	16570										
AUH	549	broad.mit.edu	37	chr9	94118381	94118381	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tacactcaccatttttataaGatttttactgagtgaatttt	4	6	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:94118381G>C	uc004arf.3	-	2	354	c.319C>G	c.(319-321)CTT>GTT	p.L107V	AUH_uc004arg.3_Missense_Mutation_p.L107V|AUH_uc011ltu.1_Missense_Mutation_p.L107V	NM_001698	NP_001689	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-Coenzyme A	107	RNA-binding.				branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding				0						ATTTTTATAAGATTTTTACTG	0.289													0	0	0	0.009096	0	4	17										C	94118381	G	C	94118381	3	2	57	1	0	0	0	0	1	0	0	0	1219	942	33	1	736	1	AUH	9	94118381	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	6761550	94118381	47095050	94	16571										
C9orf5	23731	broad.mit.edu	37	chr9	111849557	111849557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttctataatgccccaccacaCatggtagcgtttctctagga	7	12	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:111849557C>T	uc004bdt.3	-	6	1248	c.1216G>A	c.(1216-1218)GTG>ATG	p.V406M	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.V406M	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	406						integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		CCCCACCACACATGGTAGCGT	0.413													0	0	0	0.004656	0	21	30										T	111849557	C	T	111849557	3	4	57	1	0	0	0	0	1	0	0	0	2486	478	17	2	1475	2	C9orf5	9	111849557	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	17731176	111849557	29363874	95	16572										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													0	0	0	0.006122	0	17	55										T	137328351	C	T	137328351	3	4	57	1	0	0	0	0	1	0	0	0	13763	855	30	1	1318	1	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	25478794	137328351	3885080	96	16573										
MYO3A	53904	broad.mit.edu	37	chr10	26463335	26463335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	taagcatcagaggattgtcaCaacaccaacagaagtagcaa	8	9	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:26463335C>T	uc001isn.2	+	30	4502	c.4142C>T	c.(4141-4143)ACA>ATA	p.T1381I	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1381					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGGATTGTCACAACACCAACA	0.398													0	0	0	0.01441	0	44	66										T	26463335	C	T	26463335	3	4	57	1	0	0	0	0	1	0	0	0	10076	478	17	2	4252	2	MYO3A	10	26463335	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		26463335	109071412	97	16574										
ZNF25	219749	broad.mit.edu	37	chr10	38241661	38241661	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tccttacactcatagggtttCtcccctgtgtgtgttttctg	8	11	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:38241661C>T	uc001ize.1	-	6	870	c.765G>A	c.(763-765)GAG>GAA	p.E255E	ZNF25_uc001izf.1_Silent_p.E219E	NM_145011	NP_659448	P17030	ZNF25_HUMAN	zinc finger protein 25	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|central_nervous_system(1)	4		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				CATAGGGTTTCTCCCCTGTGT	0.443													0	0	0	0.006999	0	36	96										T	38241661	C	T	38241661	2	4	57	1	0	0	0	0	0	0	0	1	17791	912	32	1		1	ZNF25	10	38241661	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	11778326	38241661	97293086	98	16575										
LRIT1	26103	broad.mit.edu	37	chr10	85997383	85997383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctccaggcgcagtctggagGtgtccggggggatggacgcc	19	11	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:85997383G>A	uc001kcz.1	-	2	204	c.182C>T	c.(181-183)ACC>ATC	p.T61I		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	61	LRR 1.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						CAGTCTGGAGGTGTCCGGGGG	0.662													0	0	0	0.01441	0	44	9										A	85997383	G	A	85997383	3	1	57	1	0	0	0	0	1	0	0	0	8947	1261	44	2	1701	2	LRIT1	10	85997383	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	47755722	85997383	49537364	99	16576										
GRK5	2869	broad.mit.edu	37	chr10	121189924	121189924	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	acactttcaggcagtatcgaGtgctaggaaaagggggcttc	13	8	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:121189924G>A	uc001led.2	+	7	804	c.571G>A	c.(571-573)GTG>ATG	p.V191M	GRK5_uc009xzh.2_Missense_Mutation_p.V86M|GRK5_uc010qta.1_Missense_Mutation_p.V86M	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	191	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GCAGTATCGAGTGCTAGGAAA	0.458													0	0	0	0.01441	0	46	54										A	121189924	G	A	121189924	3	1	57	1	0	0	0	0	1	0	0	0	6792	1029	36	2	597	2	GRK5	10	121189924	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	35192541	121189924	14344823	100	16577										
C10orf88	80007	broad.mit.edu	37	chr10	124692098	124692098	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tattcgctgatcaatgtaatCcataagtttcttttccatca	4	9	3	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr10:124692098C>A	uc001lgw.2	-	6	1408	c.1183G>T	c.(1183-1185)GAT>TAT	p.D395Y	C10orf88_uc001lgx.2_Missense_Mutation_p.D297Y	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	395											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		TCAATGTAATCCATAAGTTTC	0.353													1	0	2.0095e-06	0.001984	2.18626e-06	6	24										A	124692098	C	A	124692098	3	1	57	1	0	0	0	0	1	0	0	0	1622	855	30	3	158	3	C10orf88	10	124692098	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3502174	124692098	10842649	101	16578										
LRDD	55367	broad.mit.edu	37	chr11	800221	800221	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcctcgggcacccgcacaggCaccgcgccacggtagaagga	13	16	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:800221C>T	uc001lro.1	-	14	2326	c.2184G>A	c.(2182-2184)GTG>GTA	p.V728V	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Silent_p.V711V|LRDD_uc001lrl.1_Silent_p.V571V|LRDD_uc001lrm.1_Silent_p.V415V|LRDD_uc001lrn.1_Silent_p.V571V|LRDD_uc001lrp.1_Silent_p.V373V	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	728					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCGCACAGGCACCGCGCCAC	0.687													0	0	0	0.008291	0	8	18										T	800221	C	T	800221	2	4	57	1	0	0	0	0	0	0	0	1	8936	697	25	2		2	LRDD	11	800221	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		800221	134206295	102	16579										
ABCC8	6833	broad.mit.edu	37	chr11	17414623	17414623	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tatcgaactcaaggatggcaCcccgcttcaggacgatcacc	9	14	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:17414623C>A	uc001mnc.2	-	39	4787	c.4661G>T	c.(4660-4662)GGT>GTT	p.G1554V		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1554	Cytoplasmic (By similarity).|ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AAGGATGGCACCCCGCTTCAG	0.617													1	0	7.48243e-07	0.006214	8.25526e-07	9	25										A	17414623	C	A	17414623	3	1	57	1	0	0	0	0	1	0	0	0	58	507	18	4	88	4	ABCC8	11	17414623	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	16614402	17414623	117591893	103	16580										
NELL1	4745	broad.mit.edu	37	chr11	20940871	20940871	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	caagagcttttggccaagatGactgcaaaagtaggtatcta	10	7	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:20940871G>C	uc001mqe.2	+	7	903	c.750G>C	c.(748-750)ATG>ATC	p.M250I	NELL1_uc001mqf.2_Missense_Mutation_p.M250I|NELL1_uc009yid.2_Missense_Mutation_p.M278I|NELL1_uc010rdo.1_Missense_Mutation_p.M193I|NELL1_uc010rdp.1_Missense_Mutation_p.M10I	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	250					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGGCCAAGATGACTGCAAAAG	0.323													0	0	0	0.003755	0	28	40										C	20940871	G	C	20940871	3	2	57	1	0	0	0	0	1	0	0	0	10333	1290	45	1	776	1	NELL1	11	20940871	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	3526248	20940871	114065645	104	16581										
MAPK8IP1	9479	broad.mit.edu	37	chr11	45924441	45924441	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctcggacaccagcgccctgTcctatgactctgtcaagtac	9	15	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:45924441T>C	uc001nbr.2	+	5	1293	c.1123T>C	c.(1123-1125)TCC>CCC	p.S375P		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	375					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		CAGCGCCCTGTCCTATGACTC	0.672													0	0	0	0.001984	0	5	3										C	45924441	T	C	45924441	3	2	57	1	0	0	0	0	1	0	0	0	9284	1667	58	5	1141	5	MAPK8IP1	11	45924441	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	24983570	45924441	89082075	105	16582										
OR4C15	81309	broad.mit.edu	37	chr11	55322269	55322269	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctgaacacttctttgctgggGtggaggtgattgtcctcaca	12	9	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:55322269G>T	uc010rig.1	+	1	487	c.487G>T	c.(487-489)GTG>TTG	p.V163L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTTGCTGGGGTGGAGGTGAT	0.473										HNSCC(20;0.049)			1	0	6.21321e-17	0.00278	7.48772e-17	19	124										T	55322269	G	T	55322269	3	4	57	1	0	0	0	0	1	0	0	0	11048	1261	44	4	489	4	OR4C15	11	55322269	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	9397828	55322269	79684247	106	16583										
STX5	6811	broad.mit.edu	37	chr11	62592798	62592798	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	atttgaagtcattggacataGaagccagtttcgactagaag	10	6	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:62592798G>C	uc001nvh.2	-	7	708	c.554C>G	c.(553-555)TCT>TGT	p.S185C	STX5_uc010rmi.1_Missense_Mutation_p.S89C|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.S131C|STX5_uc010rmj.1_Missense_Mutation_p.S185C|STX5_uc001nvj.2_5'UTR	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	185	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						ATTGGACATAGAAGCCAGTTT	0.493													0	0	0	0.01441	0	234	155										C	62592798	G	C	62592798	3	2	57	1	0	0	0	0	1	0	0	0	15347	942	33	1	533	1	STX5	11	62592798	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	7270529	62592798	72413718	107	16584										
NRXN2	9379	broad.mit.edu	37	chr11	64374714	64374714	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcttcttggccttgctgggcGtcttgggggcagccggggcc	17	12	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64374714G>A	uc001oap.2	-	8	2466	c.1955C>T	c.(1954-1956)ACG>ATG	p.T652M	NRXN2_uc001oar.2_Missense_Mutation_p.T1698M|NRXN2_uc001oas.2_Missense_Mutation_p.T1628M|NRXN2_uc001oao.2_Missense_Mutation_p.T338M|NRXN2_uc001oaq.2_Missense_Mutation_p.T1365M	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	652	Cytoplasmic (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CTTGCTGGGCGTCTTGGGGGC	0.637													0	0	0	0.008291	0	9	31										A	64374714	G	A	64374714	3	1	57	1	0	0	0	0	1	0	0	0	10666	1145	40	2	49	2	NRXN2	11	64374714	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1781916	64374714	70631802	108	16585										
NRXN2	9379	broad.mit.edu	37	chr11	64428312	64428312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcgacagacgcccccattgcGacagggggcagatgcacact	12	14	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64428312G>A	uc001oar.2	-	11	2537	c.2098C>T	c.(2098-2100)CGC>TGC	p.R700C	NRXN2_uc001oas.2_Missense_Mutation_p.R669C|NRXN2_uc001oaq.2_Missense_Mutation_p.R367C	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCCCCATTGCGACAGGGGGCA	0.647													0	0	0	0.01441	0	41	29										A	64428312	G	A	64428312	3	1	57	1	0	0	0	0	1	0	0	0	10666	1058	37	1	3365	1	NRXN2	11	64428312	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	53598	64428312	70578204	109	16586										
SAC3D1	29901	broad.mit.edu	37	chr11	64811717	64811717	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctcggtggaagccctgcatGaggttctacagctgcctgct	13	12	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:64811717G>A	uc001ocm.2	+	2	984	c.595G>A	c.(595-597)GAG>AAG	p.E199K	SAC3D1_uc010rnv.1_Missense_Mutation_p.E186K	NM_013299	NP_037431			SAC3 domain containing 1												0						AGCCCTGCATGAGGTTCTACA	0.642													0	0	0	0.003163	0	14	56										A	64811717	G	A	64811717	3	1	57	1	0	0	0	0	1	0	0	0	13802	1291	45	1	601	1	SAC3D1	11	64811717	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	383405	64811717	70194799	110	16587										
SNX32	254122	broad.mit.edu	37	chr11	65617466	65617466	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agttcatctggctgcatgatGcctacgtggagaatgaggag	14	7	2	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:65617466G>T	uc001ofr.2	+	3	344	c.217G>T	c.(217-219)GCC>TCC	p.A73S	SNX32_uc009yqt.2_3'UTR|SNX32_uc010rop.1_Missense_Mutation_p.A73S	NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	73	PX.				cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		GCTGCATGATGCCTACGTGGA	0.632													1	0	1.56738e-10	0.004289	1.78803e-10	31	22										T	65617466	G	T	65617466	3	4	57	1	0	0	0	0	1	0	0	0	14902	1319	46	4	227	4	SNX32	11	65617466	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	805749	65617466	69389050	111	16588										
RBM14	10432	broad.mit.edu	37	chr11	66384255	66384255	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cggaggagctggcagccctcTttgcgccctacggcacggtc	14	15	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:66384255T>A	uc001oit.2	+	1	203	c.64T>A	c.(64-66)TTT>ATT	p.F22I	RBM14_uc009yrh.2_Missense_Mutation_p.F22I|RBM14_uc009yri.2_Missense_Mutation_p.F22I|RBM4_uc009yrj.2_5'UTR|RBM4_uc009yrk.2_Missense_Mutation_p.F22I	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	22	RRM 1.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GGCAGCCCTCTTTGCGCCCTA	0.647													0	0	0	0.000602	0	4	17										A	66384255	T	A	66384255	3	1	57	1	0	0	0	0	1	0	0	0	13115	1609	56	5	66	5	RBM14	11	66384255	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	766789	66384255	68622261	112	16589										
DNAJB13	374407	broad.mit.edu	37	chr11	73670624	73670624	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tttggatcccagaccccatgGacaactggttacgtcttcca	8	13	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:73670624G>C	uc001ouo.2	+	3	1009	c.258G>C	c.(256-258)TGG>TGC	p.W86C		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	86					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					AGACCCCATGGACAACTGGTT	0.522													0	0	0	0.01441	0	73	23										C	73670624	G	C	73670624	3	2	57	1	0	0	0	0	1	0	0	0	4618	1183	41	1	268	1	DNAJB13	11	73670624	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	7286369	73670624	61335892	113	16590										
C2CD3	26005	broad.mit.edu	37	chr11	73817441	73817441	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gggggccaaatggagactgaCcattttcttgttgcactgga	13	8	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:73817441C>A	uc001ouu.2	-	13	2287	c.2060G>T	c.(2059-2061)GGT>GTT	p.G687V		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	687						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TGGAGACTGACCATTTTCTTG	0.383													1	0	2.32173e-10	0.004878	2.63579e-10	30	87										A	73817441	C	A	73817441	3	1	57	1	0	0	0	0	1	0	0	0	2154	507	18	4	3907	4	C2CD3	11	73817441	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	146817	73817441	61189075	114	16591										
CAPN5	726	broad.mit.edu	37	chr11	76796098	76796098	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcaggtggaagcgacccaagGtcagtgtctggtcccagctg	14	11	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:76796098G>T	uc001oxx.2	+	2	350	c.165_splice	c.e2+1	p.K55_splice	CAPN5_uc009yup.2_Splice_Site_p.K55_splice|CAPN5_uc009yuq.2_Splice_Site_p.K91_splice|CAPN5_uc001oxy.2_Splice_Site_p.K95_splice	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5						proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GCGACCCAAGGTCAGTGTCTG	0.677													1	0	8.12818e-05	0.001984	8.48944e-05	6	28										T	76796098	G	T	76796098	5	4	57	1	0	0	0	0	0	0	1	0	2629	1275	44	4	168	4	CAPN5	11	76796098	Splice_Site	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	2978657	76796098	58210418	115	16592										
ACAT1	38	broad.mit.edu	37	chr11	108009666	108009666	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	atggagagcatgtccaatgtTccatatgtaatgaacagagg	11	6	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:108009666T>C	uc001pjy.2	+	6	553	c.477T>C	c.(475-477)GTT>GTC	p.V159V	ACAT1_uc001pjx.2_Silent_p.V33V	NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	159					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	TGTCCAATGTTCCATATGTAA	0.398													0	0	0	0.01441	0	54	171										C	108009666	T	C	108009666	2	2	57	1	0	0	0	0	0	0	0	1	121	1770	62	5		5	ACAT1	11	108009666	Silent	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	31213568	108009666	26996850	116	16593										
HINFP	25988	broad.mit.edu	37	chr11	118997680	118997680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcctcctgggaaagttccccGaaaggagaatctgtggctac	12	11	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:118997680G>A	uc001pvp.2	+	3	215	c.26G>A	c.(25-27)CGA>CAA	p.R9Q	HINFP_uc010rzb.1_Missense_Mutation_p.R9Q|HINFP_uc001pvq.2_Missense_Mutation_p.R9Q	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	9					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AAAGTTCCCCGAAAGGAGAAT	0.537													0	0	0	0.01441	0	80	46										A	118997680	G	A	118997680	3	1	57	1	0	0	0	0	1	0	0	0	7110	1058	37	1	28	1	HINFP	11	118997680	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	10988014	118997680	16008836	117	16594										
PVRL1	5818	broad.mit.edu	37	chr11	119549465	119549466	+	Frame_Shift_Ins	INS	-	-	GA													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cgttcacctggaccacctggINSgagtggacgcctggccagga							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr11:119549465_119549466insGA	uc001pwv.2	-	2	261_262	c.89_90insTC	c.(88-90)TCCfs	p.S30fs	PVRL1_uc001pwu.1_Frame_Shift_Ins_p.S30fs|PVRL1_uc001pww.2_Frame_Shift_Ins_p.S30fs	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	30					adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		GGACCACCTGGGAGTGGACGCC	0.594																		6	12	---	---								GA	119549466	-	GA	119549465	7	5	57	1	0	1	1	0	0	0	0	0	12839	1219	43	0	1929	0	PVRL1	11	119549465	Frame_Shift_Ins	INS	-	TCGA-DK-A3IL-01A-11D-A20D-08	551785	119549465	15457051	118	16595										
KCNH3	23416	broad.mit.edu	37	chr12	49944089	49944089	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctccatggaggtgctcaaggGtggcaccgtgctcgccatcc	13	14	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:49944089G>T	uc001ruh.1	+	10	2155	c.1895G>T	c.(1894-1896)GGT>GTT	p.G632V	KCNH3_uc010smj.1_Missense_Mutation_p.G572V	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	632	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GTGCTCAAGGGTGGCACCGTG	0.632													1	0	6.12954e-19	0.004656	7.5023e-19	18	78										T	49944089	G	T	49944089	3	4	57	1	0	0	0	0	1	0	0	0	8033	1261	44	4	1933	4	KCNH3	12	49944089	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		49944089	83907806	119	16596										
GTSF1	121355	broad.mit.edu	37	chr12	54854248	54854248	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	atgttctgtaactatgttgcTcgcagggctgcaaaaagatg	11	7	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:54854248T>C	uc001sgb.2	-	7	486	c.400A>G	c.(400-402)AGC>GGC	p.S134G		NM_144594	NP_653195	Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	134							metal ion binding				0		Myeloproliferative disorder(1001;0.00452)				ACTATGTTGCTCGCAGGGCTG	0.413													0	0	0	0.008871	0	18	27										C	54854248	T	C	54854248	3	2	57	1	0	0	0	0	1	0	0	0	6886	1551	54	5	111	5	GTSF1	12	54854248	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	4910159	54854248	78997647	120	16597										
SILV	6490	broad.mit.edu	37	chr12	56355112	56355112	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agtactcaccattgatgatgGtattgttgacccagataacc	8	9	1	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:56355112G>T	uc001sip.2	-	3	354	c.323C>A	c.(322-324)ACC>AAC	p.T108N	SILV_uc001siq.2_Missense_Mutation_p.T108N|SILV_uc010spx.1_Intron|SILV_uc001sir.2_Missense_Mutation_p.T108N	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	108					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						ATTGATGATGGTATTGTTGAC	0.488													1	0	9.8876e-21	0.004878	1.23595e-20	32	19										T	56355112	G	T	56355112	3	4	57	1	0	0	0	0	1	0	0	0	14322	1261	44	4	1698	4	SILV	12	56355112	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1500864	56355112	77496783	121	16598										
ERBB3	2065	broad.mit.edu	37	chr12	56481649	56481649	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aaccccaaccagtgctgccaTgatgagtgtgccgggggctg	14	12	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:56481649T>A	uc001sjh.2	+	6	877	c.684T>A	c.(682-684)CAT>CAA	p.H228Q	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.H169Q|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	228	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGTGCTGCCATGATGAGTGTG	0.537													0	0	0	0.01441	0	52	121										A	56481649	T	A	56481649	3	1	57	1	0	0	0	0	1	0	0	0	5208	1461	51	5	837	5	ERBB3	12	56481649	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	126537	56481649	77370246	122	16599										
CEP290	80184	broad.mit.edu	37	chr12	88486515	88486515	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctaattctagaatccgttgcCtatcagcatcacttactgcc	5	13	3	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:88486515C>A	uc001tar.2	-	29	3748	c.3404G>T	c.(3403-3405)AGG>ATG	p.R1135M	CEP290_uc001taq.2_Missense_Mutation_p.R195M	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1135	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						AATCCGTTGCCTATCAGCATC	0.368													1	0	1.16021e-09	0.007291	1.30454e-09	28	59										A	88486515	C	A	88486515	3	1	57	1	0	0	0	0	1	0	0	0	3253	681	24	4	4139	4	CEP290	12	88486515	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	32004866	88486515	45365380	123	16600										
SRRM4	84530	broad.mit.edu	37	chr12	119568521	119568521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgaggaagggcagaagtcccGccgaaggcactcccgccgct	14	14	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:119568521G>A	uc001txa.1	+	8	945	c.653G>A	c.(652-654)CGC>CAC	p.R218H		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	218	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CAGAAGTCCCGCCGAAGGCAC	0.652													0	0	0	0.008291	0	11	10										A	119568521	G	A	119568521	3	1	57	1	0	0	0	0	1	0	0	0	15170	1087	38	2	683	2	SRRM4	12	119568521	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	31082006	119568521	14283374	124	16601										
TCTN2	79867	broad.mit.edu	37	chr12	124158196	124158196	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gacagtgaggtggaagagagGtctggactggtgttcctcca	16	7	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:124158196G>T	uc001ufp.2	+	4	430	c.302G>T	c.(301-303)GGT>GTT	p.G101V	TCTN2_uc009zya.2_Missense_Mutation_p.G100V	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	101	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGGAAGAGAGGTCTGGACTGG	0.433													1	0	2.48779e-11	0.005443	2.86584e-11	21	71										T	124158196	G	T	124158196	3	4	57	1	0	0	0	0	1	0	0	0	15720	1261	44	4	316	4	TCTN2	12	124158196	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	4589675	124158196	9693699	125	16602										
TMEM132B	114795	broad.mit.edu	37	chr12	126135372	126135372	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcagctgacctacatgctggGccccgactggcagtttgaca	12	13	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr12:126135372G>T	uc001uhe.1	+	7	1780	c.1772G>T	c.(1771-1773)GGC>GTC	p.G591V	TMEM132B_uc001uhf.1_Missense_Mutation_p.G103V	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	591	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TACATGCTGGGCCCCGACTGG	0.597													1	0	2.21704e-12	0.00278	2.57922e-12	18	53										T	126135372	G	T	126135372	3	4	57	1	0	0	0	0	1	0	0	0	16043	1203	42	4	1798	4	TMEM132B	12	126135372	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	1977176	126135372	7716523	126	16603										
CDK8	1024	broad.mit.edu	37	chr13	26828866	26828866	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agggctgcaaagttggccgaGgcacttatggtcacgtctac	13	10	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:26828866G>T	uc001uqr.1	+	1	114	c.88G>T	c.(88-90)GGC>TGC	p.G30C	CDK8_uc001uqs.1_Missense_Mutation_p.G30C|CDK8_uc001uqt.1_Translation_Start_Site	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	30	Protein kinase.|ATP (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGTTGGCCGAGGCACTTATGG	0.592													1	0	5.3912e-06	0.006122	5.81162e-06	16	21										T	26828866	G	T	26828866	3	4	57	1	0	0	0	0	1	0	0	0	3150	1000	35	4	90	4	CDK8	13	26828866	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		26828866	88341012	127	16604										
N4BP2L2	10443	broad.mit.edu	37	chr13	33096357	33096357	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	catttcccaagcttgtatatTagtgttatctattataactg	5	7	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:33096357T>C	uc001uuk.3	-	4	1613	c.1435A>G	c.(1435-1437)AAT>GAT	p.N479D	N4BP2L2_uc001uuj.2_5'UTR|N4BP2L2_uc010abe.1_Missense_Mutation_p.N50D|N4BP2L2_uc010tdz.1_Missense_Mutation_p.N35D	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	479											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GCTTGTATATTAGTGTTATCT	0.254													0	0	0	0.01441	0	51	68										C	33096357	T	C	33096357	3	2	57	1	0	0	0	0	1	0	0	0	10112	1754	61	5	2189	5	N4BP2L2	13	33096357	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	6267491	33096357	82073521	128	16605										
RB1	5925	broad.mit.edu	37	chr13	48955538	48955538	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aaatgataaaacatttagaaCgatgtgaacatcgaatcatg	7	5	1	3	rs121913303		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:48955538C>T	uc001vcb.2	+	17	1820	c.1654C>T	c.(1654-1656)CGA>TGA	p.R552*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	552	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.R552*(5)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACATTTAGAACGATGTGAACA	0.323	R552*(NCIH1048_LUNG)	6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.00278	0	17	24										T	48955538	C	T	48955538	4	4	57	1	0	0	0	0	0	1	0	0	13098	528	19	2	1720	2	RB1	13	48955538	Nonsense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	15859181	48955538	66214340	129	16606										
KLHL1	57626	broad.mit.edu	37	chr13	70314576	70314576	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctccgagcaattgacatactGgctacaaatgtccattgttg	8	10	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:70314576G>A	uc001vip.2	-	8	2546	c.1752C>T	c.(1750-1752)GCC>GCT	p.A584A	KLHL1_uc010thm.1_Silent_p.A523A	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	584	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTGACATACTGGCTACAAATG	0.403													0	0	0	0.006999	0	31	42										A	70314576	G	A	70314576	2	1	57	1	0	0	0	0	0	0	0	1	8365	1335	47	2		2	KLHL1	13	70314576	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	21359038	70314576	44855302	130	16607										
GPC5	2262	broad.mit.edu	37	chr13	92560246	92560246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cccagtctggaaatcctgaaGtcaaagtcaaaggaattgat	9	8	3	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr13:92560246G>A	uc010tif.1	+	6	1702	c.1336G>A	c.(1336-1338)GTC>ATC	p.V446I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	446						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AAATCCTGAAGTCAAAGTCAA	0.378													0	0	0	0.007835	0	36	38										A	92560246	G	A	92560246	3	1	57	1	0	0	0	0	1	0	0	0	6601	1029	36	2	1358	2	GPC5	13	92560246	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	22245670	92560246	22609632	131	16608										
FAM179B	23116	broad.mit.edu	37	chr14	45431955	45431955	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcactgcccgggatccttctGaggccttccaggctttgcaa	11	14	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:45431955G>A	uc001wvv.2	+	1	540	c.331G>A	c.(331-333)GAG>AAG	p.E111K	FAM179B_uc001wvw.2_Missense_Mutation_p.E111K|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.E111K|FAM179B_uc001wvu.2_Missense_Mutation_p.E111K	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	111							binding			skin(2)|upper_aerodigestive_tract(1)	3						GGATCCTTCTGAGGCCTTCCA	0.622													0	0	0	0.009535	0	24	71										A	45431955	G	A	45431955	3	1	57	1	0	0	0	0	1	0	0	0	5506	1291	45	1	333	1	FAM179B	14	45431955	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		45431955	61917585	132	16609										
SYT16	83851	broad.mit.edu	37	chr14	62547819	62547819	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcagggagaaggtcacctttGccaagctggagcccagagat	13	10	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:62547819G>C	uc001xfu.1	+	4	1458	c.1261G>C	c.(1261-1263)GCC>CCC	p.A421P	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	421	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GGTCACCTTTGCCAAGCTGGA	0.567													0	0	0	0.004007	0	12	10										C	62547819	G	C	62547819	3	2	57	1	0	0	0	0	1	0	0	0	15469	1319	46	4	1275	4	SYT16	14	62547819	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	17115864	62547819	44801721	133	16610										
KIAA1409	57578	broad.mit.edu	37	chr14	94004365	94004365	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cccacgttagaagagcagttGtcacctgcttctcagcaggg	11	12	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr14:94004365G>C	uc001ybv.1	+	9	705	c.622G>C	c.(622-624)GTC>CTC	p.V208L	KIAA1409_uc001ybs.1_Missense_Mutation_p.V208L|KIAA1409_uc001ybu.1_Missense_Mutation_p.V146L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	385						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AAGAGCAGTTGTCACCTGCTT	0.468													0	0	0	0.004656	0	23	22										C	94004365	G	C	94004365	3	2	57	1	0	0	0	0	1	0	0	0	8230	1377	48	4	656	4	KIAA1409	14	94004365	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	31456546	94004365	13345175	134	16611										
SHC4	399694	broad.mit.edu	37	chr15	49118194	49118194	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gttggaatgcaaaagtgctgGattattatcttttctcactg	9	6	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:49118194G>C	uc001zxb.1	-	12	2296	c.1867C>G	c.(1867-1869)CCA>GCA	p.P623A	SHC4_uc010uey.1_Missense_Mutation_p.P380A|SHC4_uc010uez.1_Missense_Mutation_p.P337A	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	623					intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		AAAAGTGCTGGATTATTATCT	0.373													0	0	0	0.01441	0	47	127										C	49118194	G	C	49118194	3	2	57	1	0	0	0	0	1	0	0	0	14273	1174	41	1	29	1	SHC4	15	49118194	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		49118194	53413198	135	16612										
PSTPIP1	9051	broad.mit.edu	37	chr15	77323595	77323595	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtgcacagcaaccagctctcCatgcagtgtgtcaaggatga	11	11	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:77323595C>T	uc002bcf.2	+	10	1167	c.717C>T	c.(715-717)TCC>TCT	p.S239S	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010umo.1_Silent_p.S117S|PSTPIP1_uc010bku.1_Silent_p.S230S|PSTPIP1_uc002bcg.2_Silent_p.S239S|PSTPIP1_uc010bkw.1_Silent_p.S239S|PSTPIP1_uc002bch.1_5'UTR|PSTPIP1_uc002bci.1_5'Flank	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	239					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1						ACCAGCTCTCCATGCAGTGTG	0.617													0	0	0	0.01441	0	65	100										T	77323595	C	T	77323595	2	4	57	1	0	0	0	0	0	0	0	1	12721	581	21	2		2	PSTPIP1	15	77323595	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	28205401	77323595	25207797	136	16613										
LRRK1	79705	broad.mit.edu	37	chr15	101595287	101595287	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aacattctggtgtggtccctTgacgtcaaggagcacatcaa	10	10	3	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr15:101595287T>A	uc002bwr.2	+	27	4510	c.4191T>A	c.(4189-4191)CTT>CTA	p.L1397L	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1397	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGTGGTCCCTTGACGTCAAGG	0.532													0	0	0	0.007291	0	22	59										A	101595287	T	A	101595287	2	1	57	1	0	0	0	0	0	0	0	1	9032	1799	63	5		5	LRRK1	15	101595287	Silent	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	24271692	101595287	936105	137	16614										
ZNF205	7755	broad.mit.edu	37	chr16	3168975	3168975	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgaggcctcgggctccagccGgcaggcaggagatgagaagg	18	10	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:3168975G>T	uc002cub.2	+	6	689	c.554G>T	c.(553-555)CGG>CTG	p.R185L	ZNF205_uc002cua.2_Missense_Mutation_p.R185L	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	185	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						GGCTCCAGCCGGCAGGCAGGA	0.667													1	0	3.09479e-21	0.006999	3.91008e-21	31	62										T	3168975	G	T	3168975	3	4	57	1	0	0	0	0	1	0	0	0	17761	1116	39	4	572	4	ZNF205	16	3168975	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08		3168975	87185778	138	16615										
ANKS3	124401	broad.mit.edu	37	chr16	4764077	4764077	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctccgatagaggctcttgggCagagagggcgagtaagtgtc	16	8	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:4764077C>G	uc002cxj.1	-	7	979	c.684G>C	c.(682-684)CTG>CTC	p.L228L	ANKS3_uc002cxi.1_Silent_p.L155L|ANKS3_uc002cxk.2_Silent_p.L99L|ANKS3_uc002cxl.2_Silent_p.L55L|ANKS3_uc010uxs.1_Silent_p.L155L|ANKS3_uc002cxm.2_Silent_p.L22L	NM_133450	NP_597707	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain	228											0						GGCTCTTGGGCAGAGAGGGCG	0.607													0	0	0	0.007413	0	18	36										G	4764077	C	G	4764077	2	3	57	1	0	0	0	0	0	0	0	1	690	697	25	4		4	ANKS3	16	4764077	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1595102	4764077	85590676	139	16616										
RBBP6	5930	broad.mit.edu	37	chr16	24582981	24582981	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gaacaggagattccaaaaaaAgtaattctagtccctcaaga	7	8	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:24582981A>G	uc002dmh.2	+	18	5634	c.4594A>G	c.(4594-4596)AGT>GGT	p.S1532G	RBBP6_uc002dmi.2_Missense_Mutation_p.S1498G|RBBP6_uc010bxr.2_Missense_Mutation_p.S692G|RBBP6_uc002dmk.2_Missense_Mutation_p.S1365G	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1532	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TTCCAAAAAAAGTAATTCTAG	0.373													0	0	0	0.009096	0	3	14										G	24582981	A	G	24582981	3	3	57	1	0	0	0	0	1	0	0	0	13103	72	3	5	4718	5	RBBP6	16	24582981	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	19818904	24582981	65771772	140	16617										
ATXN2L	11273	broad.mit.edu	37	chr16	28834730	28834730	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	acctctgcggctcctcccggGcctccagcggccgcctcccc	10	23	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:28834730G>T	uc002drc.2	+	1	318	c.150G>T	c.(148-150)GGG>GGT	p.G50G	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.G50G|ATXN2L_uc002drb.2_Silent_p.G50G|ATXN2L_uc002dqy.2_Silent_p.G50G|ATXN2L_uc002dra.2_Silent_p.G50G|ATXN2L_uc002dqz.2_Silent_p.G50G|ATXN2L_uc010vdb.1_Silent_p.G50G|ATXN2L_uc002dre.2_Silent_p.G50G	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	50	Pro-rich.					membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CTCCTCCCGGGCCTCCAGCGG	0.821													1	0	0.00909568	0.009096	0.00925318	2	2										T	28834730	G	T	28834730	2	4	57	1	0	0	0	0	0	0	0	1	1212	1190	42	4		4	ATXN2L	16	28834730	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	4251749	28834730	61520023	141	16618										
CPNE2	221184	broad.mit.edu	37	chr16	57157339	57157339	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cttccagataaaccgagactActccttccttgactacatcc	4	15	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:57157339A>G	uc002eks.1	+	10	1110	c.881A>G	c.(880-882)TAC>TGC	p.Y294C	CPNE2_uc010cct.1_Missense_Mutation_p.Y320C|CPNE2_uc010ccu.1_Missense_Mutation_p.Y294C|CPNE2_uc002ekt.1_5'Flank	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	294										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				AACCGAGACTACTCCTTCCTT	0.498													0	0	0	0.01441	0	63	72										G	57157339	A	G	57157339	3	3	57	1	0	0	0	0	1	0	0	0	3812	391	14	5	915	5	CPNE2	16	57157339	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	28322609	57157339	33197414	142	16619										
CX3CL1	6376	broad.mit.edu	37	chr16	57416702	57416708	+	Frame_Shift_Del	DEL	ACCATGG	ACCATGG	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctgaggaacccatccatgccAccatggacccccagaggctg							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:57416702_57416708delACCATGG	uc002eli.2	+	3	1019_1025	c.952_958delACCATGG	c.(952-960)ACCATGGACfs	p.T318fs		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	318_320	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						CATCCATGCCACCATGGACCCCCAGAG	0.662																		17	72	---	---								-	57416708	ACCATGG	-	57416702	7	5	57	1	0	1	0	1	0	0	0	0	4074	159	6	0	962	0	CX3CL1	16	57416702	Frame_Shift_Del	DEL	ACCATGG	TCGA-DK-A3IL-01A-11D-A20D-08	259363	57416702	32938051	143	16620										
CES2	8824	broad.mit.edu	37	chr16	66969416	66969416	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gccagcgcaccccgctgactCcctgcccagtccaaactcca	7	21	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:66969416C>G	uc002eqr.2	+	1	1070	c.70C>G	c.(70-72)CCC>GCC	p.P24A	CES2_uc002eqq.2_Missense_Mutation_p.P24A|CES2_uc002eqs.2_5'UTR|FAM96B_uc002eqp.2_5'Flank	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	Error:Variant_position_missing_in_O00748_after_alignment					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCCGCTGACTCCCTGCCCAGT	0.662													0	0	0	0.01441	0	46	165										G	66969416	C	G	66969416	3	3	57	1	0	0	0	0	1	0	0	0	3270	855	30	1	72	1	CES2	16	66969416	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	9552714	66969416	23385337	144	16621										
ATMIN	23300	broad.mit.edu	37	chr16	81076953	81076953	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctaacactgacaagcagactCttacaacaccaccgagatat	5	13	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:81076953C>G	uc002ffz.1	+	4	868	c.850C>G	c.(850-852)CTT>GTT	p.L284V	ATMIN_uc002fga.2_Missense_Mutation_p.L126V|ATMIN_uc010vnn.1_Missense_Mutation_p.L55V|ATMIN_uc002fgb.1_Missense_Mutation_p.L126V	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	284	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						CAAGCAGACTCTTACAACACC	0.433													0	0	0	0.003271	0	33	59										G	81076953	C	G	81076953	3	3	57	1	0	0	0	0	1	0	0	0	1110	913	32	1	864	1	ATMIN	16	81076953	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	14107537	81076953	9277800	145	16622										
CDH13	1012	broad.mit.edu	37	chr16	82891976	82891976	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggttttctcaggtgctgctgCtaacatctgcagaagatttg	11	8	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:82891976C>T	uc002fgx.2	+	2	175	c.55C>T	c.(55-57)CTA>TTA	p.L19L	CDH13_uc010chh.2_Silent_p.L19L|CDH13_uc010vns.1_Silent_p.L66L|CDH13_uc010vnt.1_5'UTR|CDH13_uc010vnu.1_Silent_p.L19L	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	19					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GGTGCTGCTGCTAACATCTGC	0.418													0	0	0	0.004878	0	35	28										T	82891976	C	T	82891976	2	4	57	1	0	0	0	0	0	0	0	1	3099	796	28	2		2	CDH13	16	82891976	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1815023	82891976	7462777	146	16623										
BANP	54971	broad.mit.edu	37	chr16	88008777	88008777	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gattgcagtggaagacctgaGccctgaccacccaggtacag	12	12	0	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr16:88008777G>C	uc002fkr.2	+	2	277	c.53G>C	c.(52-54)AGC>ACC	p.S18T	BANP_uc002fkp.2_Missense_Mutation_p.S19T|BANP_uc002fkq.2_Missense_Mutation_p.S19T|BANP_uc010vow.1_Missense_Mutation_p.S18T|BANP_uc002fks.3_Missense_Mutation_p.S18T|BANP_uc002fko.1_Intron|BANP_uc010vov.1_Missense_Mutation_p.S18T	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	19					cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		GAAGACCTGAGCCCTGACCAC	0.473													0	0	0	0.003271	0	26	50										C	88008777	G	C	88008777	3	2	57	1	0	0	0	0	1	0	0	0	1310	971	34	4	58	4	BANP	16	88008777	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	5116801	88008777	2345976	147	16624										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006999	0	34	17										T	7577538	C	T	7577538	3	4	57	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		7577538	73617672	148	16625										
CHD3	1107	broad.mit.edu	37	chr17	7802505	7802505	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	caaaccatcgtcttcctctaCtcactctacaaggaggtgct	6	14	4	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:7802505C>T	uc002gje.2	+	14	2478	c.2328C>T	c.(2326-2328)TAC>TAT	p.Y776Y	CHD3_uc002gjd.2_Silent_p.Y835Y|CHD3_uc002gjf.2_Silent_p.Y776Y	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	776	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TCTTCCTCTACTCACTCTACA	0.567													0	0	0	0.01441	0	58	18										T	7802505	C	T	7802505	2	4	57	1	0	0	0	0	0	0	0	1	3326	576	20	2		2	CHD3	17	7802505	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	224967	7802505	73392705	149	16626										
C17orf48	56985	broad.mit.edu	37	chr17	10608309	10608309	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cgtcttttctcctttggcgtCatcgcagatgttcaatttgc	8	11	4	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:10608309C>T	uc002gmt.2	+	2	141	c.66C>T	c.(64-66)GTC>GTT	p.V22V	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Silent_p.V22V	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	22							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						CCTTTGGCGTCATCGCAGATG	0.423													0	0	0	0.004482	0	8	48										T	10608309	C	T	10608309	2	4	57	1	0	0	0	0	0	0	0	1	1859	813	29	1		1	C17orf48	17	10608309	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	2805804	10608309	70586901	150	16627										
SSH2	85464	broad.mit.edu	37	chr17	27959241	27959241	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctcctgaggatctggcaagtGgtcaaactccagcaccctgg	11	13	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:27959241G>T	uc002heo.1	-	15	2890	c.2890C>A	c.(2890-2892)CAC>AAC	p.H964N	SSH2_uc010wbh.1_Missense_Mutation_p.H991N	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	964					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCTGGCAAGTGGTCAAACTCC	0.547													1	0	1.64293e-13	0.00333	1.94015e-13	23	19										T	27959241	G	T	27959241	3	4	57	1	0	0	0	0	1	0	0	0	15184	1348	47	4	1385	4	SSH2	17	27959241	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	17350932	27959241	53235969	151	16628										
LRRC37B	114659	broad.mit.edu	37	chr17	30348423	30348423	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcttcgcagatgtcagccctGcctcaggaaccaactgaaaa	8	13	3	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:30348423G>C	uc002hgu.2	+	1	269	c.258G>C	c.(256-258)CTG>CTC	p.L86L	LRRC37B_uc010wbx.1_Silent_p.L4L|LRRC37B_uc010csu.2_Silent_p.L86L	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	86	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TGTCAGCCCTGCCTCAGGAAC	0.592													0	0	0	0.004007	0	16	57										C	30348423	G	C	30348423	2	2	57	1	0	0	0	0	0	0	0	1	8994	1306	46	4		4	LRRC37B	17	30348423	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	2389182	30348423	50846787	152	16629										
AMAC1	146861	broad.mit.edu	37	chr17	33520917	33520917	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cggcggagcagacggtggaaGaacctttgcgaacagtggca	16	9	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:33520917G>T	uc002hjd.2	-	1	496	c.410C>A	c.(409-411)TCT>TAT	p.S137Y		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	137	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GACGGTGGAAGAACCTTTGCG	0.587													1	0	1.48734e-19	0.013114	1.82997e-19	32	136										T	33520917	G	T	33520917	3	4	57	1	0	0	0	0	1	0	0	0	559	942	33	3	610	3	AMAC1	17	33520917	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	3172494	33520917	47674293	153	16630										
MAP3K14	9020	broad.mit.edu	37	chr17	43351496	43351496	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggcctgggccttacctttgaCgtccccatgcagaatccttc	9	15	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:43351496C>G	uc002iiw.1	-	9	1655	c.1546G>C	c.(1546-1548)GTC>CTC	p.V516L	MAP3K14_uc002iiu.1_5'Flank|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Missense_Mutation_p.V100L	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	516	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						TTACCTTTGACGTCCCCATGC	0.617													0	0	0	0.009096	0	3	3										G	43351496	C	G	43351496	3	3	57	1	0	0	0	0	1	0	0	0	9248	536	19	4	1333	4	MAP3K14	17	43351496	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	9830579	43351496	37843714	154	16631										
ATP5G1	516	broad.mit.edu	37	chr17	46971758	46971758	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctgttgtaccaggggtctaAtcaggcctgtgtctgcctcc	12	12	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:46971758A>G	uc002iog.2	+	3	198	c.64A>G	c.(64-66)ATC>GTC	p.I22V	ATP5G1_uc002ioh.2_Missense_Mutation_p.I22V	NM_005175	NP_005166	P05496	AT5G1_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	22					ATP hydrolysis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding				0						CAGGGGTCTAATCAGGCCTGT	0.438													0	0	0	0.01441	0	50	125										G	46971758	A	G	46971758	3	3	57	1	0	0	0	0	1	0	0	0	1153	101	4	5	70	5	ATP5G1	17	46971758	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	3620262	46971758	34223452	155	16632										
MFSD11	79157	broad.mit.edu	37	chr17	74740413	74740413	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tttctccgtagagagtgaccGaagaacagtgtttattgccc	10	9	1	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:74740413G>C	uc002jta.2	+	8	1479	c.506G>C	c.(505-507)CGA>CCA	p.R169P	MFSD11_uc002jtb.2_Missense_Mutation_p.R169P|MFSD11_uc010dha.2_Missense_Mutation_p.R117P|MFSD11_uc002jtc.2_Missense_Mutation_p.R169P|MFSD11_uc002jtd.3_Missense_Mutation_p.R169P|MFSD11_uc010dhb.2_Missense_Mutation_p.R117P|MFSD11_uc002jte.2_Missense_Mutation_p.R169P	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	169						integral to membrane				ovary(1)	1						GAGAGTGACCGAAGAACAGTG	0.413													0	0	0	0.004289	0	25	48										C	74740413	G	C	74740413	3	2	57	1	0	0	0	0	1	0	0	0	9529	1058	37	1	532	1	MFSD11	17	74740413	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	27768655	74740413	6454797	156	16633										
TSPAN10	83882	broad.mit.edu	37	chr17	79612041	79612041	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	actgcaggccagaagcccctCtctgtgcacaggccacccac	9	18	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr17:79612041C>T	uc010die.2	+	2	150	c.60C>T	c.(58-60)CTC>CTT	p.L20L	TSPAN10_uc002kaw.1_Silent_p.L20L|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	20						integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGAAGCCCCTCTCTGTGCACA	0.647													0	0	0	0.013537	0	10	28										T	79612041	C	T	79612041	2	4	57	1	0	0	0	0	0	0	0	1	16631	900	32	1		1	TSPAN10	17	79612041	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	4871628	79612041	1583169	157	16634										
NDC80	10403	broad.mit.edu	37	chr18	2575029	2575029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aaagttgagtataaacaaacCgacatctgaaagaaaagtct	7	6	2	3			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:2575029C>T	uc002kli.2	+	3	325	c.143C>T	c.(142-144)CCG>CTG	p.P48L		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	48	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						ATAAACAAACCGACATCTGAA	0.303													0	0	0	0.004007	0	10	12										T	2575029	C	T	2575029	3	4	57	1	0	0	0	0	1	0	0	0	10242	652	23	2	149	2	NDC80	18	2575029	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		2575029	75502219	158	16635										
RNF152	220441	broad.mit.edu	37	chr18	59483323	59483323	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cggtgacggacttctgctggCtcccgggcagcaggcggcag	17	13	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr18:59483323C>G	uc002lih.1	-	2	786	c.374G>C	c.(373-375)AGC>ACC	p.S125T		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	125					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				CTTCTGCTGGCTCCCGGGCAG	0.662													0	0	0	0.00333	0	19	7										G	59483323	C	G	59483323	3	3	57	1	0	0	0	0	1	0	0	0	13453	797	28	4	241	4	RNF152	18	59483323	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	56908294	59483323	18593925	159	16636										
MLLT1	4298	broad.mit.edu	37	chr19	6230639	6230639	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tggggttgttgaaggtgagcTtctcgcagcgcaggtggttc	17	7	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:6230639T>C	uc002mek.2	-	4	526	c.362A>G	c.(361-363)AAG>AGG	p.K121R		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	121					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						GAAGGTGAGCTTCTCGCAGCG	0.647			T	MLL	AL								0	0	0	0.01441	0	83	31										C	6230639	T	C	6230639	3	2	57	1	0	0	0	0	1	0	0	0	9625	1609	56	5	1353	5	MLLT1	19	6230639	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08		6230639	52898344	160	16637										
CNN1	1264	broad.mit.edu	37	chr19	11660487	11660487	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	aagggcgcctcgcagcggggCatgacggtgtatgggctgcc	18	11	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:11660487C>A	uc002msc.1	+	7	935	c.771C>A	c.(769-771)GGC>GGA	p.G257G	CNN1_uc010xmb.1_Silent_p.G207G|CNN1_uc010xmc.1_Silent_p.G207G	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	257	Calponin-like 3.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						CGCAGCGGGGCATGACGGTGT	0.652													1	0	7.76418e-22	0.005443	9.91621e-22	28	9										A	11660487	C	A	11660487	2	1	57	1	0	0	0	0	0	0	0	1	3609	697	25	4		4	CNN1	19	11660487	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	5429848	11660487	47468496	161	16638										
MED26	9441	broad.mit.edu	37	chr19	16686879	16686879	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cagaatgttcaagcgcccgtCgtcgccgtgcggatcgagcg	14	13	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:16686879C>T	uc002nen.1	-	3	2023	c.1762G>A	c.(1762-1764)GAC>AAC	p.D588N	MED26_uc002nee.2_Intron	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	588					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2						AAGCGCCCGTCGTCGCCGTGC	0.537													0	0	0	0.01441	0	45	6										T	16686879	C	T	16686879	3	4	57	1	0	0	0	0	1	0	0	0	9444	884	31	1	44	1	MED26	19	16686879	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	5026392	16686879	42442104	162	16639										
GMIP	51291	broad.mit.edu	37	chr19	19740837	19740837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggtggccctgggcacagcctCgctgtccaatttcgagagta	13	12	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:19740837C>T	uc002nnd.2	-	21	2965	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	LPAR2_uc002nnb.3_5'Flank|LPAR2_uc002nna.3_5'Flank|LPAR2_uc002nnc.3_5'Flank|GMIP_uc010xrb.1_Missense_Mutation_p.E924K|GMIP_uc010xrc.1_Missense_Mutation_p.E921K	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	950					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GGCACAGCCTCGCTGTCCAAT	0.637													0	0	0	0.004672	0	2	1										T	19740837	C	T	19740837	3	4	57	1	0	0	0	0	1	0	0	0	6491	893	31	1	68	1	GMIP	19	19740837	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3053958	19740837	39388146	163	16640										
ZNF536	9745	broad.mit.edu	37	chr19	31039827	31039827	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtgcatggaccggccacgtgGaccctgcattttgtaacttc	11	12	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:31039827G>A	uc002nsu.1	+	4	3439	c.3301G>A	c.(3301-3303)GAC>AAC	p.D1101N	ZNF536_uc010edd.1_Missense_Mutation_p.D1101N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CGGCCACGTGGACCCTGCATT	0.542													0	0	0	0.004656	0	21	41										A	31039827	G	A	31039827	3	1	57	1	0	0	0	0	1	0	0	0	17971	1174	41	1	3311	1	ZNF536	19	31039827	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	11298990	31039827	28089156	164	16641										
ZNF302	55900	broad.mit.edu	37	chr19	35175840	35175840	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cttttagtcgtgtgtcccttCtcattcagcatctaagaatt	6	10	3	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:35175840C>G	uc002nvr.1	+	6	1293	c.1030C>G	c.(1030-1032)CTC>GTC	p.L344V	ZNF302_uc002nvp.1_Missense_Mutation_p.L300V|ZNF302_uc002nvq.1_Missense_Mutation_p.L300V|ZNF302_uc002nvs.1_Missense_Mutation_p.L300V	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	379	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGTGTCCCTTCTCATTCAGCA	0.423													0	0	0	0.00245	0	12	50										G	35175840	C	G	35175840	3	3	57	1	0	0	0	0	1	0	0	0	17829	913	32	1	912	1	ZNF302	19	35175840	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	4136013	35175840	23953143	165	16642										
ZNF420	147923	broad.mit.edu	37	chr19	37619520	37619520	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtggaaaggcctttgcgcgtGgcttactacttatacaacat	10	9	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:37619520G>A	uc002ofl.2	+	5	1842	c.1627G>A	c.(1627-1629)GGC>AGC	p.G543S		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	543	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTTTGCGCGTGGCTTACTACT	0.413													0	0	0	0.00632	0	28	54										A	37619520	G	A	37619520	3	1	57	1	0	0	0	0	1	0	0	0	17894	1348	47	2	1637	2	ZNF420	19	37619520	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	2443680	37619520	21509463	166	16643										
PLEKHG2	64857	broad.mit.edu	37	chr19	39913486	39913486	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cttcagaagaggaggaggagGaagaggaagggctggagatg	20	3	1	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:39913486G>A	uc010xuz.1	+	18	2117	c.1792G>A	c.(1792-1794)GAA>AAA	p.E598K	PLEKHG2_uc010xuy.1_Missense_Mutation_p.E539K|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.E376K	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	598	Poly-Glu.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGAGGAGGAGGAAGAGGAAGG	0.602													0	0	0	0.000602	0	5	12										A	39913486	G	A	39913486	3	1	57	1	0	0	0	0	1	0	0	0	12069	1175	41	1	1858	1	PLEKHG2	19	39913486	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	2293966	39913486	19215497	167	16644										
ZNF780A	284323	broad.mit.edu	37	chr19	40580973	40580973	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttcgagaatgttcaataagtTggcaatgatatctaaaggcc	9	6	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:40580973T>C	uc002omy.2	-	6	1601	c.1376A>G	c.(1375-1377)CAA>CGA	p.Q459R	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.Q459R|ZNF780A_uc010xvh.1_Missense_Mutation_p.Q460R	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	459	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTCAATAAGTTGGCAATGATA	0.403													0	0	0	0.01441	0	68	104										C	40580973	T	C	40580973	3	2	57	1	0	0	0	0	1	0	0	0	18149	1812	63	5	680	5	ZNF780A	19	40580973	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	667487	40580973	18548010	168	16645										
PLD3	23646	broad.mit.edu	37	chr19	40882622	40882622	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	actcggagccatccatgcggGccttcctgctctctctggct	10	16	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:40882622G>C	uc002onm.3	+	11	1524	c.1126G>C	c.(1126-1128)GCC>CCC	p.A376P	PLD3_uc002onj.3_Missense_Mutation_p.A376P|PLD3_uc002onk.3_Missense_Mutation_p.A376P|PLD3_uc002onl.3_Missense_Mutation_p.A376P|PLD3_uc002onn.2_Missense_Mutation_p.A376P	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	376	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			ATCCATGCGGGCCTTCCTGCT	0.652													0	0	0	0.01441	0	43	53										C	40882622	G	C	40882622	3	2	57	1	0	0	0	0	1	0	0	0	12047	1203	42	4	1160	4	PLD3	19	40882622	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	301649	40882622	18246361	169	16646										
LIPE	3991	broad.mit.edu	37	chr19	42911490	42911490	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctcgtgggatctggaggtcTgggccacaaagccaccgccg	15	13	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:42911490T>A	uc002otr.2	-	6	2250	c.1973A>T	c.(1972-1974)CAG>CTG	p.Q658L	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	658					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TCTGGAGGTCTGGGCCACAAA	0.687													0	0	0	0.001984	0	6	5										A	42911490	T	A	42911490	3	1	57	1	0	0	0	0	1	0	0	0	8821	1580	55	5	1277	5	LIPE	19	42911490	Missense_Mutation	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	2028868	42911490	16217493	170	16647										
KCNN4	3783	broad.mit.edu	37	chr19	44284956	44284956	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggccagagacttctcctgctCcagcaagcgctttcggcgtc	11	15	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:44284956C>T	uc002oxl.2	-	1	454	c.58G>A	c.(58-60)GAG>AAG	p.E20K	KCNN4_uc010eja.1_RNA	NM_002250	NP_002241	O15554	KCNN4_HUMAN	intermediate conductance calcium-activated	20					defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TTCTCCTGCTCCAGCAAGCGC	0.662													0	0	0	0.01441	0	53	83										T	44284956	C	T	44284956	3	4	57	1	0	0	0	0	1	0	0	0	8081	864	30	1	1257	1	KCNN4	19	44284956	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1373466	44284956	14844027	171	16648										
DHX34	9704	broad.mit.edu	37	chr19	47876898	47876898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	actctcgcaagtggtgccgcCgccggggcatagaggagcat	15	12	1	1	rs141177029	byFrequency	TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:47876898C>T	uc010xyn.1	+	9	2346	c.2005C>T	c.(2005-2007)CGC>TGC	p.R669C		NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	669						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GTGGTGCCGCCGCCGGGGCAT	0.657													0	0	0	0.003954	0	17	30										T	47876898	C	T	47876898	3	4	57	1	0	0	0	0	1	0	0	0	4507	652	23	2	2035	2	DHX34	19	47876898	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3591942	47876898	11252085	172	16649										
MYBPC2	4606	broad.mit.edu	37	chr19	50961863	50961863	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gccgaggaatgggtccctgcCaacaccgagcccgtggagcg	15	14	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:50961863C>G	uc002psf.2	+	21	2409	c.2358C>G	c.(2356-2358)GCC>GCG	p.A786A		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	786	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GGGTCCCTGCCAACACCGAGC	0.657													0	0	0	0.00499	0	14	34										G	50961863	C	G	50961863	2	3	57	1	0	0	0	0	0	0	0	1	10012	581	21	4		4	MYBPC2	19	50961863	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3084965	50961863	8167120	173	16650										
NKG7	4818	broad.mit.edu	37	chr19	51875242	51875244	+	In_Frame_Del	DEL	AGG	AGG	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccagcccaggtagaaggaccAggagaagaaggtctggatct							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:51875242_51875244delAGG	uc002pwj.2	-	3	560_562	c.389_391delCCT	c.(388-393)TCCTGG>TGG	p.S130del	CLDND2_uc002pwi.1_5'Flank|NKG7_uc002pwk.2_In_Frame_Del_p.S95del	NM_005601	NP_005592	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	130						integral to plasma membrane				central_nervous_system(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGAAGGACCAGGAGAAGAAGGT	0.611																		26	74	---	---								-	51875244	AGG	-	51875242	7	5	57	1	0	1	0	1	0	0	0	0	10443	188	7	0	114	0	NKG7	19	51875242	In_Frame_Del	DEL	AGG	TCGA-DK-A3IL-01A-11D-A20D-08	913379	51875242	7253741	174	16651										
BIRC8	112401	broad.mit.edu	37	chr19	53793189	53793189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tagatctgcaacaagaacctCaagcgttttatagttgctcc	7	10	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:53793189C>G	uc002qbk.2	-	1	1687	c.439G>C	c.(439-441)GAG>CAG	p.E147Q		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	147					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		ACAAGAACCTCAAGCGTTTTA	0.398													0	0	0	0.004289	0	31	70										G	53793189	C	G	53793189	3	3	57	1	0	0	0	0	1	0	0	0	1440	835	29	1	275	1	BIRC8	19	53793189	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1917947	53793189	5335794	175	16652										
ZNF331	55422	broad.mit.edu	37	chr19	54080062	54080062	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	taaatcccttggccgtaactGgatatgtgaaggtacgcttg	11	8	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:54080062G>T	uc002qbx.1	+	7	1682	c.248G>T	c.(247-249)TGG>TTG	p.W83L	ZNF331_uc002qby.1_Missense_Mutation_p.W83L|ZNF331_uc002qbz.1_Missense_Mutation_p.W83L|ZNF331_uc002qca.1_Missense_Mutation_p.W83L|ZNF331_uc010eqr.1_Missense_Mutation_p.W83L|ZNF331_uc002qcb.1_Missense_Mutation_p.W83L|ZNF331_uc002qcc.1_Missense_Mutation_p.W83L|ZNF331_uc002qcd.1_Missense_Mutation_p.W83L	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	83					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		GGCCGTAACTGGATATGTGAA	0.398			T	NaN	follicular thyroid adenoma								1	0	3.86212e-05	0.008291	4.05178e-05	10	51										T	54080062	G	T	54080062	3	4	57	1	0	0	0	0	1	0	0	0	17846	1357	47	4	258	4	ZNF331	19	54080062	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	286873	54080062	5048921	176	16653										
LILRB1	10859	broad.mit.edu	37	chr19	55148021	55148021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cagacctaggagagaaatggCctctcctccttccccactgt	8	15	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:55148021C>T	uc002qgj.2	+	15	2064	c.1724C>T	c.(1723-1725)GCC>GTC	p.A575V	LILRB1_uc010erp.1_3'UTR|LILRB1_uc002qgl.2_Missense_Mutation_p.A576V|LILRB1_uc002qgk.2_Missense_Mutation_p.A576V|LILRB1_uc002qgm.2_Missense_Mutation_p.A577V|LILRB1_uc010erq.2_Missense_Mutation_p.A559V|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	575	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGAGAAATGGCCTCTCCTCCT	0.582										HNSCC(37;0.09)			0	0	0	0.010818	0	28	31										T	55148021	C	T	55148021	3	4	57	1	0	0	0	0	1	0	0	0	8790	739	26	2	1780	2	LILRB1	19	55148021	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1067959	55148021	3980962	177	16654										
NLRP8	126205	broad.mit.edu	37	chr19	56482062	56482062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggcccagctggagaggctgtCgtaagtctcctttctagtgg	14	10	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:56482062C>T	uc002qmh.2	+	6	2605	c.2534C>T	c.(2533-2535)TCG>TTG	p.S845L	NLRP8_uc010etg.2_Missense_Mutation_p.S845L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	845	LRR 3.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGAGGCTGTCGTAAGTCTCC	0.473													0	0	0	0.01441	0	66	94										T	56482062	C	T	56482062	3	4	57	1	0	0	0	0	1	0	0	0	10483	898	31	1	2556	1	NLRP8	19	56482062	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1334041	56482062	2646921	178	16655										
ZNF324B	388569	broad.mit.edu	37	chr19	58965138	58965138	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tcctggacacagcgcagaggGccctgtaccgccacgtgatg	13	14	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:58965138G>A	uc002qsv.1	+	2	177	c.70G>A	c.(70-72)GCC>ACC	p.A24T	ZNF324B_uc002qsu.1_5'UTR|ZNF324B_uc010euq.1_Missense_Mutation_p.A24T	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		AGCGCAGAGGGCCCTGTACCG	0.567													0	0	0	0.01441	0	39	58										A	58965138	G	A	58965138	3	1	57	1	0	0	0	0	1	0	0	0	17842	1203	42	2	72	2	ZNF324B	19	58965138	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	2483076	58965138	163845	179	16656										
ZBTB45	84878	broad.mit.edu	37	chr19	59028486	59028486	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccctcagccttggcaggtgtTgggggcgctggcagctgcaa	16	12	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr19:59028486T>C	uc002qtd.2	-	2	847	c.555A>G	c.(553-555)CCA>CCG	p.P185P	ZBTB45_uc002qte.2_Silent_p.P185P|ZBTB45_uc002qtf.2_Silent_p.P185P	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	185	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		TGGCAGGTGTTGGGGGCGCTG	0.692											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	31	36										C	59028486	T	C	59028486	2	2	57	1	0	0	0	0	0	0	0	1	17543	1799	63	5		5	ZBTB45	19	59028486	Silent	SNP	T	TCGA-DK-A3IL-01A-11D-A20D-08	63348	59028486	100497	180	16657										
RALGAPA2	57186	broad.mit.edu	37	chr20	20610169	20610169	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctgttagaatggcttttgtcCtgctccgtgggcccaccacc	10	14	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:20610169C>A	uc002wrz.2	-	10	1214	c.1071G>T	c.(1069-1071)CAG>CAT	p.Q357H	RALGAPA2_uc010gcx.2_Missense_Mutation_p.Q61H|RALGAPA2_uc010zsg.1_Translation_Start_Site	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	357					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GGCTTTTGTCCTGCTCCGTGG	0.537													1	0	2.27795e-59	0.01441	3.11231e-59	104	111										A	20610169	C	A	20610169	3	1	57	1	0	0	0	0	1	0	0	0	13014	680	24	4	4670	4	RALGAPA2	20	20610169	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		20610169	42415351	181	16658										
WFDC3	140686	broad.mit.edu	37	chr20	44418583	44418583	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gagacccaagagcaagaagtGccttcagaagaaagaggcag	13	8	1	6			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:44418583G>T	uc002xpf.1	-	2	116	c.32C>A	c.(31-33)GCA>GAA	p.A11E	DNTTIP1_uc002xpk.2_5'Flank|WFDC3_uc002xpj.1_Intron|WFDC3_uc002xph.1_Intron|WFDC3_uc010ghh.1_Intron	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	11						extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				AGCAAGAAGTGCCTTCAGAAG	0.483													1	0	6.53348e-20	0.003755	8.08088e-20	28	63										T	44418583	G	T	44418583	3	4	57	1	0	0	0	0	1	0	0	0	17350	1319	46	4	687	4	WFDC3	20	44418583	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	23808414	44418583	18606937	182	16659										
ZNF831	128611	broad.mit.edu	37	chr20	57768368	57768368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtggcagatgcccccagcacCtggccccctcaaagggggtg	14	15	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:57768368C>T	uc002yan.2	+	1	2294	c.2294C>T	c.(2293-2295)CCT>CTT	p.P765L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	765						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCCCCAGCACCTGGCCCCCTC	0.647													0	0	0	0.001168	0	5	9										T	57768368	C	T	57768368	3	4	57	1	0	0	0	0	1	0	0	0	18182	681	24	2	2296	2	ZNF831	20	57768368	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	13349785	57768368	5257152	183	16660										
DIDO1	11083	broad.mit.edu	37	chr20	61513072	61513072	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gctgcagctgcttcaggagcCctttccacctcgtggcgccg	12	16	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:61513072C>G	uc002ydr.1	-	16	4500	c.4236G>C	c.(4234-4236)AGG>AGC	p.R1412S	DIDO1_uc002yds.1_Missense_Mutation_p.R1412S	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1412					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTCAGGAGCCCTTTCCACCT	0.612													0	0	0	0.01441	0	69	70										G	61513072	C	G	61513072	3	3	57	1	0	0	0	0	1	0	0	0	4522	622	22	4	2490	4	DIDO1	20	61513072	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3744704	61513072	1512448	184	16661										
SAMD10	140700	broad.mit.edu	37	chr20	62608657	62608657	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tctggctgcgggagtcatgcCacgtgaggctggtgccaggt	17	10	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62608657C>G	uc002yhm.2	-	2	369	c.194G>C	c.(193-195)TGG>TCG	p.W65S	SAMD10_uc002yhn.2_RNA	NM_080621	NP_542188	Q9BYL1	SAM10_HUMAN	sterile alpha motif domain containing 10	65											0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGAGTCATGCCACGTGAGGCT	0.667													0	0	0	0.01441	0	98	80										G	62608657	C	G	62608657	3	3	57	1	0	0	0	0	1	0	0	0	13815	595	21	4	430	4	SAMD10	20	62608657	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	1095585	62608657	416863	185	16662										
PRPF6	24148	broad.mit.edu	37	chr20	62664245	62664245	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agagtgcagagcctcggcatGgggagctgtggtgcgccgtg	19	9	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62664245G>T	uc002yho.2	+	21	2893	c.2725G>T	c.(2725-2727)GGG>TGG	p.G909W	PRPF6_uc002yhp.2_Missense_Mutation_p.G869W|NCRNA00176_uc002yhq.2_5'Flank|NCRNA00176_uc011abq.1_5'Flank	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	909					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GCCTCGGCATGGGGAGCTGTG	0.642													1	0	7.92952e-12	0.003954	9.1795e-12	25	23										T	62664245	G	T	62664245	3	4	57	1	0	0	0	0	1	0	0	0	12574	1348	47	4	2807	4	PRPF6	20	62664245	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	55588	62664245	361275	186	16663										
MYT1	4661	broad.mit.edu	37	chr20	62871155	62871155	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tgaagaacatcgaggaggagAacaagctcattgaggagcag	14	6	1	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr20:62871155A>G	uc002yii.2	+	22	3500	c.3136A>G	c.(3136-3138)AAC>GAC	p.N1046D	MYT1_uc002yij.2_Missense_Mutation_p.N705D|MYT1_uc002yik.2_Missense_Mutation_p.N12D	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1046					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CGAGGAGGAGAACAAGCTCAT	0.572													0	0	0	0.01441	0	88	73										G	62871155	A	G	62871155	3	3	57	1	0	0	0	0	1	0	0	0	10106	246	9	5	3214	5	MYT1	20	62871155	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	206910	62871155	154365	187	16664										
BAGE2	85319	broad.mit.edu	37	chr21	11097575	11097575	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccatcttcaggctccaacctCcagctcaccacaggggactc	7	18	3	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr21:11097575C>A	uc002yit.1	-	2	295	c.87G>T	c.(85-87)TGG>TGT	p.W29C	BAGE_uc002yix.2_RNA	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gctccaacctccagctcacca	0.095													1	0	9.31168e-06	0.001855	9.90156e-06	11	79										A	11097575	C	A	11097575	3	1	57	1	0	0	0	0	1	0	0	0	1292	856	30	3	254	3	BAGE2	21	11097575	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		11097575	37032320	188	16665										
PDE9A	5152	broad.mit.edu	37	chr21	44192566	44192566	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cagttacagaagaagactgaCagcttgacgtctggggccac	12	10	1	5			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr21:44192566C>A	uc002zbm.2	+	19	1767	c.1704C>A	c.(1702-1704)GAC>GAA	p.D568E	PDE9A_uc002zbn.2_Missense_Mutation_p.D441E|PDE9A_uc002zbo.2_Missense_Mutation_p.D515E|PDE9A_uc002zbp.2_Missense_Mutation_p.D361E|PDE9A_uc002zbq.2_Missense_Mutation_p.D466E|PDE9A_uc002zbs.2_Missense_Mutation_p.D361E|PDE9A_uc002zbr.2_Missense_Mutation_p.D361E|PDE9A_uc002zbt.2_Missense_Mutation_p.D440E|PDE9A_uc002zbu.2_Missense_Mutation_p.D434E|PDE9A_uc002zbv.2_Missense_Mutation_p.D408E|PDE9A_uc002zbw.2_Missense_Mutation_p.D351E|PDE9A_uc002zbx.2_Missense_Mutation_p.D508E|PDE9A_uc002zby.2_Missense_Mutation_p.D351E|PDE9A_uc002zbz.2_Missense_Mutation_p.D460E|PDE9A_uc002zca.2_Missense_Mutation_p.D527E|PDE9A_uc002zcb.2_Missense_Mutation_p.D542E|PDE9A_uc002zcc.2_Missense_Mutation_p.D467E|PDE9A_uc002zcd.2_Missense_Mutation_p.D482E|PDE9A_uc002zce.2_Missense_Mutation_p.D501E|PDE9A_uc002zcf.2_Missense_Mutation_p.D361E|PDE9A_uc002zcg.2_Missense_Mutation_p.D361E|PDE9A_uc002zch.2_Missense_Mutation_p.D351E	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	568					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						AGAAGACTGACAGCTTGACGT	0.532													1	0	2.0095e-06	0.001984	2.18626e-06	5	18										A	44192566	C	A	44192566	3	1	57	1	0	0	0	0	1	0	0	0	11655	477	17	4	1858	4	PDE9A	21	44192566	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	33094991	44192566	3937329	189	16666										
OR11H1	81061	broad.mit.edu	37	chr22	16449133	16449133	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccaataataaagaggaagttAccaaaaataactaatgagct	6	6	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:16449133A>C	uc011agd.1	-	1	672	c.672T>G	c.(670-672)GGT>GGG	p.G224G		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	224	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		AGAGGAAGTTACCAAAAATAA	0.433													0	0	0	0.01441	0	25	31										C	16449133	A	C	16449133	2	2	57	1	0	0	0	0	0	0	0	1	10926	378	14	5		5	OR11H1	22	16449133	Silent	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08		16449133	34855433	190	16667										
MYO18B	84700	broad.mit.edu	37	chr22	26173598	26173598	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctgcccacattggctccatgGcacagcgggcatactgggcg	13	14	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:26173598G>T	uc003abz.1	+	8	2168	c.1918G>T	c.(1918-1920)GCA>TCA	p.A640S	MYO18B_uc003aca.1_Missense_Mutation_p.A521S|MYO18B_uc010guy.1_Missense_Mutation_p.A521S|MYO18B_uc010guz.1_Missense_Mutation_p.A521S|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_Missense_Mutation_p.A153S	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	640	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TGGCTCCATGGCACAGCGGGC	0.647													1	0	1.12685e-05	0.004482	1.19284e-05	6	30										T	26173598	G	T	26173598	3	4	57	1	0	0	0	0	1	0	0	0	10066	1203	42	4	1944	4	MYO18B	22	26173598	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	9724465	26173598	25130968	191	16668										
MYO18B	84700	broad.mit.edu	37	chr22	26219621	26219621	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttgggccaagccgatggggcCtcgaggatgaggaaaccagc	16	10	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:26219621C>A	uc003abz.1	+	13	2921	c.2671C>A	c.(2671-2673)CTC>ATC	p.L891I	MYO18B_uc003aca.1_Missense_Mutation_p.L772I|MYO18B_uc010guy.1_Missense_Mutation_p.L772I|MYO18B_uc010guz.1_Missense_Mutation_p.L772I|MYO18B_uc011aka.1_Missense_Mutation_p.L45I|MYO18B_uc011akb.1_Missense_Mutation_p.L404I	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	891	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCGATGGGGCCTCGAGGATGA	0.597													1	0	3.45943e-77	0.01441	4.78215e-77	103	112										A	26219621	C	A	26219621	3	1	57	1	0	0	0	0	1	0	0	0	10066	681	24	4	2717	4	MYO18B	22	26219621	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	46023	26219621	25084945	192	16669										
IL2RB	3560	broad.mit.edu	37	chr22	37524836	37524836	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ctagtggcgagatctcaggtGccaggccgccagggctgaag	16	11	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:37524836G>T	uc003aqv.1	-	10	1087	c.956C>A	c.(955-957)GCA>GAA	p.A319E		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	319	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GATCTCAGGTGCCAGGCCGCC	0.627													1	0	3.99206e-14	0.007413	4.7621e-14	14	37										T	37524836	G	T	37524836	3	4	57	1	0	0	0	0	1	0	0	0	7687	1319	46	4	703	4	IL2RB	22	37524836	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	11305215	37524836	13779730	193	16670										
SGSM3	27352	broad.mit.edu	37	chr22	40804819	40804819	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ttggatgaagatggcaaagtCctgaccccggaggagctgct	14	9	0	3	rs140197200		TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:40804819C>T	uc003ayu.1	+	18	2084	c.1875C>T	c.(1873-1875)GTC>GTT	p.V625V	SGSM3_uc011aos.1_Silent_p.V558V|SGSM3_uc011aot.1_Silent_p.V536V|SGSM3_uc010gyd.1_Silent_p.V696V	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	625	RUN.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						ATGGCAAAGTCCTGACCCCGG	0.652													0	0	0	0.012319	0	15	49										T	40804819	C	T	40804819	2	4	57	1	0	0	0	0	0	0	0	1	14224	842	30	1		1	SGSM3	22	40804819	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3279983	40804819	10499747	194	16671										
TEF	7008	broad.mit.edu	37	chr22	41783535	41783535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ggagaatggcatccccgccaGccccacccacctggcccaca	9	20	0	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:41783535G>A	uc003azy.2	+	2	424	c.338G>A	c.(337-339)AGC>AAC	p.S113N	TEF_uc003azx.2_Missense_Mutation_p.S83N|TEF_uc011apa.1_Missense_Mutation_p.S118N	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	113					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ATCCCCGCCAGCCCCACCCAC	0.587													0	0	0	0.01441	0	100	81										A	41783535	G	A	41783535	3	1	57	1	0	0	0	0	1	0	0	0	15747	971	34	2	415	2	TEF	22	41783535	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	978716	41783535	9521031	195	16672										
MAPK11	5600	broad.mit.edu	37	chr22	50705436	50705436	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cgcgtggccacatagccggtCatctcctcgtccgcctggcg	12	17	2	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chr22:50705436C>T	uc003bkr.2	-	7	595	c.537G>A	c.(535-537)ATG>ATA	p.M179I	MAPK11_uc010hax.2_Missense_Mutation_p.M1I|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_3'UTR|MAPK11_uc010haz.2_Missense_Mutation_p.M71I	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	179	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATAGCCGGTCATCTCCTCGT	0.657													0	0	0	0.010729	0	12	44										T	50705436	C	T	50705436	3	4	57	1	0	0	0	0	1	0	0	0	9273	826	29	1	581	1	MAPK11	22	50705436	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	8921901	50705436	599130	196	16673										
SHROOM2	357	broad.mit.edu	37	chrX	9900619	9900619	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gcccttcccaacgccatcccCtgcgtccctggatgtgtatg	9	17	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:9900619C>T	uc004csu.1	+	6	3386	c.3296C>T	c.(3295-3297)CCT>CTT	p.P1099L	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1099					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				ACGCCATCCCCTGCGTCCCTG	0.692													0	0	0	0.001984	0	6	52										T	9900619	C	T	9900619	3	4	57	1	0	0	0	0	1	0	0	0	14294	681	24	2	3318	2	SHROOM2	23	9900619	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08		9900619	145369941	197	16674										
DMD	1756	broad.mit.edu	37	chrX	32383166	32383166	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	atttaaccactcttctgctcGggaggtgacagctatccagt	9	11	2	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:32383166G>T	uc004dda.1	-	35	5240	c.4996C>A	c.(4996-4998)CGA>AGA	p.R1666R	DMD_uc004dcw.2_Silent_p.R322R|DMD_uc004dcx.2_Silent_p.R325R|DMD_uc004dcz.2_Silent_p.R1543R|DMD_uc004dcy.1_Silent_p.R1662R|DMD_uc004ddb.1_Silent_p.R1658R|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1666	Spectrin 11.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTCTGCTCGGGAGGTGACA	0.428													1	0	3.30226e-22	0.01441	4.24061e-22	49	44										T	32383166	G	T	32383166	2	4	57	1	0	0	0	0	0	0	0	1	4580	1124	39	4		4	DMD	23	32383166	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	22482547	32383166	122887394	198	16675										
CXorf22	170063	broad.mit.edu	37	chrX	35993361	35993361	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cctatgcatgttttgctccaGttagatactgatttagaaga	8	7	0	4			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:35993361G>A	uc004ddj.2	+	14	2411	c.2352G>A	c.(2350-2352)CAG>CAA	p.Q784Q	CXorf22_uc010ngv.2_Splice_Site	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	784										large_intestine(1)|lung(1)|ovary(1)	3						TTTTGCTCCAGTTAGATACTG	0.358													0	0	0	0.01441	0	90	83										A	35993361	G	A	35993361	2	1	57	1	0	0	0	0	0	0	0	1	4102	1020	36	2		2	CXorf22	23	35993361	Silent	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	3610195	35993361	119277199	199	16676										
HDAC6	10013	broad.mit.edu	37	chrX	48682372	48682372	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	accactgccctggtgtccccAtttggtggcagtatgcccca	10	15	0	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:48682372A>G	uc011mmi.1	+	27	3439	c.3344A>G	c.(3343-3345)CAT>CGT	p.H1115R	HDAC6_uc004dks.1_Missense_Mutation_p.H1115R|HDAC6_uc010nig.1_Missense_Mutation_p.H963R|HDAC6_uc004dkt.1_Missense_Mutation_p.H1115R|HDAC6_uc011mmk.1_Missense_Mutation_p.H1096R|HDAC6_uc004dkv.1_Missense_Mutation_p.H763R|HDAC6_uc004dkw.1_Missense_Mutation_p.H763R|HDAC6_uc004dkx.1_Missense_Mutation_p.H478R	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1115		Zinc 1.			aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGGTGTCCCCATTTGGTGGCA	0.517													0	0	0	0.007835	0	34	86										G	48682372	A	G	48682372	3	3	57	1	0	0	0	0	1	0	0	0	7011	217	8	5	3446	5	HDAC6	23	48682372	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	12689011	48682372	106588188	200	16677										
PJA1	64219	broad.mit.edu	37	chrX	68382762	68382762	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccattcctcttctgctacccGaagctctgtactctcttggc	6	16	4	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:68382762G>A	uc004dxh.2	-	2	606	c.320C>T	c.(319-321)TCG>TTG	p.S107L	PJA1_uc011mpi.1_5'UTR|PJA1_uc004dxg.2_Intron|PJA1_uc004dxi.2_Missense_Mutation_p.S52L	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	107							zinc ion binding				0						TCTGCTACCCGAAGCTCTGTA	0.522													0	0	0	0.014323	0	20	99										A	68382762	G	A	68382762	3	1	57	1	0	0	0	0	1	0	0	0	11961	1059	37	1	1615	1	PJA1	23	68382762	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	19700390	68382762	86887798	201	16678										
OGT	8473	broad.mit.edu	37	chrX	70775117	70775117	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	cggcaacctggcttgtgtatActatgagcaaggcctgatag	12	9	0	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:70775117A>G	uc004eaa.1	+	7	1023	c.806A>G	c.(805-807)TAC>TGC	p.Y269C	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.Y259C|OGT_uc004eac.2_Missense_Mutation_p.Y130C|OGT_uc004ead.2_Intron	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	269	TPR 7.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					GCTTGTGTATACTATGAGCAA	0.453													0	0	0	0.01441	0	64	72										G	70775117	A	G	70775117	3	3	57	1	0	0	0	0	1	0	0	0	10847	391	14	5	832	5	OGT	23	70775117	Missense_Mutation	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	2392355	70775117	84495443	202	16679										
PSMD10	5716	broad.mit.edu	37	chrX	107331994	107331994	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtactcacatcgtctttatcAttcactggcactccaagttg	6	12	4	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:107331994A>G	uc004enp.1	-	2	299	c.201T>C	c.(199-201)AAT>AAC	p.N67N	ATG4A_uc004enr.2_5'Flank|ATG4A_uc004ent.2_5'Flank|ATG4A_uc004ens.2_5'Flank|ATG4A_uc011msl.1_5'Flank|ATG4A_uc010npi.2_5'Flank|PSMD10_uc004enq.1_Silent_p.N67N|PSMD10_uc010nph.1_Silent_p.N67N	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	67	Interaction with RELA.|ANK 2.|Interaction with RB1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						CGTCTTTATCATTCACTGGCA	0.413													0	0	0	0.01441	0	212	193										G	107331994	A	G	107331994	2	3	57	1	0	0	0	0	0	0	0	1	12693	214	8	5		5	PSMD10	23	107331994	Silent	SNP	A	TCGA-DK-A3IL-01A-11D-A20D-08	36556877	107331994	47938566	203	16680										
COL4A5	1287	broad.mit.edu	37	chrX	107938638	107938638	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	ccaactcctacagcttttggCtggcaactgtagatgtgtca	9	11	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:107938638C>A	uc004enz.1	+	51	5165	c.4963C>A	c.(4963-4965)CTG>ATG	p.L1655M	COL4A5_uc011mso.1_Missense_Mutation_p.L1652M|COL4A5_uc011msp.1_Missense_Mutation_p.L331M	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1649	Collagen IV NC1.		L -> R (in APSX; adult type).|Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CAGCTTTTGGCTGGCAACTGT	0.463									Alport_syndrome_with_Diffuse_Leiomyomatosis				1	0	4.02486e-48	0.01441	5.40481e-48	54	68										A	107938638	C	A	107938638	3	1	57	1	0	0	0	0	1	0	0	0	3694	796	28	4	5154	4	COL4A5	23	107938638	Missense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	606644	107938638	47331922	204	16681										
KLHL13	90293	broad.mit.edu	37	chrX	117054334	117054334	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	agtcgaagctggtcaaagccCtacaacaagaacatgagttg	10	9	1	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:117054334C>A	uc004eql.2	-	3	303	c.241_splice	c.e3-1	p.G81_splice	KLHL13_uc004eqk.2_Splice_Site_p.G30_splice|KLHL13_uc011mtn.1_Splice_Site|KLHL13_uc011mto.1_Splice_Site_p.G75_splice|KLHL13_uc011mtp.1_Splice_Site_p.G83_splice|KLHL13_uc004eqm.2_Splice_Site_p.G30_splice|KLHL13_uc011mtq.1_Splice_Site_p.G65_splice	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13						cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GGTCAAAGCCCTACAACAAGA	0.408													1	0	3.94638e-17	0.01441	4.7804e-17	46	49										A	117054334	C	A	117054334	5	1	57	1	0	0	0	0	0	0	1	0	8369	695	24	4	1747	4	KLHL13	23	117054334	Splice_Site	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	9115696	117054334	38216226	205	16682										
THOC2	57187	broad.mit.edu	37	chrX	122754808	122754808	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	gtgagtatcaattttgcggcGtttttgttctgttaagacaa	10	5	2	2			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:122754808G>A	uc004etu.2	-	32	4257	c.4225C>T	c.(4225-4227)CGC>TGC	p.R1409C	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Missense_Mutation_p.R230C	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1409	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ATTTTGCGGCGTTTTTGTTCT	0.398													0	0	0	0.01441	0	147	118										A	122754808	G	A	122754808	3	1	57	1	0	0	0	0	1	0	0	0	15862	1145	40	2	584	2	THOC2	23	122754808	Missense_Mutation	SNP	G	TCGA-DK-A3IL-01A-11D-A20D-08	5700474	122754808	32515752	206	16683										
FRMD7	90167	broad.mit.edu	37	chrX	131233527	131233527	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tttgttatgggcttcaaaagCtccagccaaacctgtaataa	7	9	1	0			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:131233527C>T	uc004ewn.2	-	3	352	c.174G>A	c.(172-174)GAG>GAA	p.E58E	FRMD7_uc011muy.1_Silent_p.E58E	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	58	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCTTCAAAAGCTCCAGCCAAA	0.343													0	0	0	0.01441	0	50	117										T	131233527	C	T	131233527	2	4	57	1	0	0	0	0	0	0	0	1	6055	796	28	2		2	FRMD7	23	131233527	Silent	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	8478719	131233527	24037033	207	16684										
DDX26B	203522	broad.mit.edu	37	chrX	134680317	134680317	+	Frame_Shift_Del	DEL	T	T	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tattttaggggagaaatccaTtttttttagaaccatctatt							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:134680317delT	uc004eyw.3	+	4	715	c.352delT	c.(352-354)TTTfs	p.F118fs		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	118	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAAATCCATTTTTTTTAGA	0.269																		34	41	---	---								-	134680317	T	-	134680317	7	5	57	1	0	1	0	1	0	0	0	0	4353	1493	52	0	366	0	DDX26B	23	134680317	Frame_Shift_Del	DEL	T	TCGA-DK-A3IL-01A-11D-A20D-08	3446790	134680317	20590243	208	16685										
CD99L2	83692	broad.mit.edu	37	chrX	149984524	149984526	+	In_Frame_Del	DEL	GTG	GTG	-													0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	tggttcctggcctattggttGtggtggtggtggtgtggtcc							TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:149984524_149984526delGTG	uc004fel.2	-	3	274_276	c.156_158delCAC	c.(154-159)ACCACA>ACA	p.52_53TT>T	CD99L2_uc004fek.2_5'Flank|CD99L2_uc004fem.2_Intron|CD99L2_uc004fen.2_Intron|CD99L2_uc004feo.2_RNA|CD99L2_uc011myb.1_In_Frame_Del_p.52_53TT>T	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4	52_53	Extracellular (Potential).|Poly-Thr.				cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552																		7	457	---	---								-	149984526	GTG	-	149984524	7	5	57	1	0	1	0	1	0	0	0	0	3051	1377	48	0	666	0	CD99L2	23	149984524	In_Frame_Del	DEL	GTG	TCGA-DK-A3IL-01A-11D-A20D-08	15304207	149984524	5286036	209	16686										
PLXNB3	5365	broad.mit.edu	37	chrX	153038980	153038980	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1	21	0.0549175552045706	1.45499453759559	2.30720562390158	1.13936080192671	0.585368358421571	0.7111952018206	0	catcctggtacaggggtgggCgactgatccgtgtcaggggc	17	10	1	1			TCGA-DK-A3IL-01A-11D-A20D-08	TCGA-DK-A3IL-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4838b5a9-968c-4178-bffb-3fafe1f6dc09	c1da8eed-4919-4ba5-a735-3fba476c18a7	g.chrX:153038980C>T	uc004fii.2	+	19	3265	c.3091C>T	c.(3091-3093)CGA>TGA	p.R1031*	PLXNB3_uc010nuk.2_Nonsense_Mutation_p.R1054*|PLXNB3_uc011mzd.1_Nonsense_Mutation_p.R670*|PLXNB3_uc004fij.1_5'Flank|SRPK3_uc004fik.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1031	IPT/TIG 3.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGGGTGGGCGACTGATCCG	0.687													0	0	0	0.009718	0	36	28										T	153038980	C	T	153038980	4	4	57	1	0	0	0	0	0	1	0	0	12125	760	27	2	3279	2	PLXNB3	23	153038980	Nonsense_Mutation	SNP	C	TCGA-DK-A3IL-01A-11D-A20D-08	3054456	153038980	2231580	210	16687										
CHD5	26038	broad.mit.edu	37	chr1	6219573	6219573	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tctgatagctcatcattgctCccctggaaaagaagggggac	11	10	3	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:6219573C>T	uc001amb.1	-	3	310	c.210G>A	c.(208-210)GGG>GGA	p.G70G		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	70	Lys-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CATCATTGCTCCCCTGGAAAA	0.507													0	0	0	0.038147	0	6	7										T	6219573	C	T	6219573	2	4	58	1	0	0	0	0	0	0	0	1	3328	842	30	1		1	CHD5	1	6219573	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		6219573	243031048	1	16688										
TNFRSF25	8718	broad.mit.edu	37	chr1	6521714	6521714	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gcacgaactccttccagcgcCgcgctgggaccgcgtccatc	11	18	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:6521714C>T	uc001ane.2	-	10	1122	c.1034G>A	c.(1033-1035)CGG>CAG	p.R345Q	TNFRSF25_uc001ana.2_Missense_Mutation_p.R162Q|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Missense_Mutation_p.R118Q|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.R308Q|TNFRSF25_uc001ang.2_Missense_Mutation_p.R300Q|TNFRSF25_uc001anh.2_Missense_Mutation_p.R354Q	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	345	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CTTCCAGCGCCGCGCTGGGAC	0.692													0	0	0	0.115264	0	3	12										T	6521714	C	T	6521714	3	4	58	1	0	0	0	0	1	0	0	0	16293	652	23	2	223	2	TNFRSF25	1	6521714	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	302141	6521714	242728907	2	16689										
RERE	473	broad.mit.edu	37	chr1	8418613	8418613	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cagctctgggggcttcacctCgaagcccggcttcatcctct	10	16	4	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:8418613C>T	uc001ape.2	-	21	4792	c.3982G>A	c.(3982-3984)GAG>AAG	p.E1328K	RERE_uc001apf.2_Missense_Mutation_p.E1328K|RERE_uc001apd.2_Missense_Mutation_p.E774K	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1328					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGCTTCACCTCGAAGCCCGGC	0.721													0	0	0	0.043863	0	17	8										T	8418613	C	T	8418613	3	4	58	1	0	0	0	0	1	0	0	0	13231	893	31	1	734	1	RERE	1	8418613	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	1896899	8418613	240832008	3	16690										
ARID1A	8289	broad.mit.edu	37	chr1	27087417	27087417	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gagtcctggagtgagcacatCagggatttccagcagccaag	13	10	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:27087417C>G	uc001bmv.1	+	5	2364	c.1991C>G	c.(1990-1992)TCA>TGA	p.S664*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.S664*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.S664*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.S281*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	664					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.S664*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTGAGCACATCAGGGATTTCC	0.517			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.139131	0	74	86										G	27087417	C	G	27087417	4	3	58	1	0	0	0	0	0	1	0	0	913	838	29	1	2009	1	ARID1A	1	27087417	Nonsense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	18668804	27087417	222163204	4	16691										
PPCS	79717	broad.mit.edu	37	chr1	42925522	42925522	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcagaggaagaaatagaaaaAggcgtagagatagaagagaa	13	2	1	6			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:42925522A>G	uc001chl.2	+	3	925	c.861A>G	c.(859-861)AAA>AAG	p.K287K	PPCS_uc001chk.2_Silent_p.K114K	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	287					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AAATAGAAAAAGGCGTAGAGA	0.388													0	0	0	0.115264	0	3	93										G	42925522	A	G	42925522	2	3	58	1	0	0	0	0	0	0	0	1	12305	69	3	5		5	PPCS	1	42925522	Silent	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	15838105	42925522	206325099	5	16692										
MYSM1	114803	broad.mit.edu	37	chr1	59127114	59127114	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	atttttctattatccatcttGtcttttcaaatactaatccc	1	10	4	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:59127114G>T	uc009wab.1	-	18	2257	c.2234C>A	c.(2233-2235)ACA>AAA	p.T745K	uc001cza.2_5'Flank|MYSM1_uc009waa.1_Missense_Mutation_p.T151K|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	745					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TATCCATCTTGTCTTTTCAAA	0.373													1	0	0.00909568	0.150653	0.00923144	3	56										T	59127114	G	T	59127114	3	4	58	1	0	0	0	0	1	0	0	0	10101	1377	48	4	264	4	MYSM1	1	59127114	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	16201592	59127114	190123507	6	16693										
PTGFR	5737	broad.mit.edu	37	chr1	78958573	78958573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgtcaaacagccttgccatcGccattctcatgaaggcatat	7	12	2	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:78958573G>A	uc001din.2	+	2	411	c.145G>A	c.(145-147)GCC>ACC	p.A49T	PTGFR_uc001dim.2_Missense_Mutation_p.A49T	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	49	Helical; Name=1; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CCTTGCCATCGCCATTCTCAT	0.448													0	0	0	0.139131	0	61	49										A	78958573	G	A	78958573	3	1	58	1	0	0	0	0	1	0	0	0	12749	1087	38	2	147	2	PTGFR	1	78958573	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	19831459	78958573	170292048	7	16694										
S1PR1	1901	broad.mit.edu	37	chr1	101705632	101705632	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcctcccacccccagaaagaCgaaggggacaacccagagac	9	16	0	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:101705632C>T	uc001dud.2	+	2	1606	c.1092C>T	c.(1090-1092)GAC>GAT	p.D364D	S1PR1_uc009weg.2_Silent_p.D364D	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	364	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						CCCAGAAAGACGAAGGGGACA	0.547													0	0	0	0.163468	0	29	55										T	101705632	C	T	101705632	2	4	58	1	0	0	0	0	0	0	0	1	13793	535	19	2		2	S1PR1	1	101705632	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	22747059	101705632	147544989	8	16695										
SNX27	81609	broad.mit.edu	37	chr1	151640977	151640977	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tggcacctaatgagtttcctCacaaactctacattcagaat	5	11	3	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:151640977C>T	uc001eyn.1	+	7	1031	c.1015C>T	c.(1015-1017)CAC>TAC	p.H339Y	SNX27_uc001eyo.2_Missense_Mutation_p.H246Y|SNX27_uc001eyp.2_Missense_Mutation_p.H153Y	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	339	Ras-associating.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGAGTTTCCTCACAAACTCTA	0.363													0	0	0	0.163468	0	25	185										T	151640977	C	T	151640977	3	4	58	1	0	0	0	0	1	0	0	0	14897	826	29	1	1041	1	SNX27	1	151640977	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	49935345	151640977	97609644	9	16696										
HRNR	388697	broad.mit.edu	37	chr1	152188034	152188034	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ggccacagctcgatgactgtCctgatgcagaaccatgttgc	11	12	0	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:152188034C>G	uc001ezt.1	-	3	6147	c.6071G>C	c.(6070-6072)GGA>GCA	p.G2024A		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2024	22.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGATGACTGTCCTGATGCAGA	0.562													0	0	0	0.139131	0	84	269										G	152188034	C	G	152188034	3	3	58	1	0	0	0	0	1	0	0	0	7359	855	30	1	2485	1	HRNR	1	152188034	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	547057	152188034	97062587	10	16697										
FLG	2312	broad.mit.edu	37	chr1	152277090	152277090	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgaccctcttgggacgctgaGtgcctggagctgtctcgtgc	14	12	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:152277090G>A	uc001ezu.1	-	3	10308	c.10272C>T	c.(10270-10272)CAC>CAT	p.H3424H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3424	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGACGCTGAGTGCCTGGAGC	0.597									Ichthyosis				0	0	0	0.139131	0	249	349										A	152277090	G	A	152277090	2	1	58	1	0	0	0	0	0	0	0	1	5922	1020	36	2		2	FLG	1	152277090	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	89056	152277090	96973531	11	16698										
FLG	2312	broad.mit.edu	37	chr1	152283897	152283897	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgaccctcttgggacgctgaGtgcctggagctgtctcgtgc	14	12	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:152283897G>A	uc001ezu.1	-	3	3501	c.3465C>T	c.(3463-3465)CAC>CAT	p.H1155H	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1155	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGGACGCTGAGTGCCTGGAGC	0.597									Ichthyosis				0	0	0	0.139131	0	15	616										A	152283897	G	A	152283897	2	1	58	1	0	0	0	0	0	0	0	1	5922	1020	36	2		2	FLG	1	152283897	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	6807	152283897	96966724	12	16699										
C1orf129	80133	broad.mit.edu	37	chr1	170961422	170961422	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gaaatggaggacaccgtaacGgaagggaaacgtttctctct	12	8	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:170961422G>A	uc001ghg.2	+	12	1276	c.1146G>A	c.(1144-1146)ACG>ACA	p.T382T	C1orf129_uc009wvy.2_Silent_p.T189T|C1orf129_uc010plz.1_Silent_p.T382T	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	382							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACACCGTAACGGAAGGGAAAC	0.473													0	0	0	0.108266	0	23	118										A	170961422	G	A	170961422	2	1	58	1	0	0	0	0	0	0	0	1	1996	1103	39	2		2	C1orf129	1	170961422	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	18677525	170961422	78289199	13	16700										
SYT14	255928	broad.mit.edu	37	chr1	210334177	210334177	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	aatccagtatataaggaaacTtttgtctttcaagtggccct	7	8	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr1:210334177T>C	uc009xcv.2	+	8	1530	c.1458T>C	c.(1456-1458)ACT>ACC	p.T486T	SYT14_uc001hhs.3_Silent_p.T550T|SYT14_uc001hht.3_Silent_p.T505T|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Silent_p.T531T|SYT14_uc010pso.1_Silent_p.T448T|SYT14_uc010psp.1_Silent_p.T24T	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	486	Cytoplasmic (Potential).|C2 2.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		ATAAGGAAACTTTTGTCTTTC	0.408													0	0	0	0.139131	0	73	12										C	210334177	T	C	210334177	2	2	58	1	0	0	0	0	0	0	0	1	15467	1596	56	5		5	SYT14	1	210334177	Silent	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	39372755	210334177	38916444	14	16701										
LTBP1	4052	broad.mit.edu	37	chr2	33359935	33359935	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gacctgcaccaagggcagctGtcagaacagctgtgagaagg	14	10	1	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr2:33359935G>C	uc002ros.2	+	5	1109	c.1109G>C	c.(1108-1110)TGT>TCT	p.C370S	LTBP1_uc002rot.2_Missense_Mutation_p.C44S|LTBP1_uc002rou.2_Missense_Mutation_p.C44S|LTBP1_uc002rov.2_Missense_Mutation_p.C44S|LTBP1_uc010ymz.1_Missense_Mutation_p.C44S|LTBP1_uc010yna.1_Missense_Mutation_p.C44S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	370					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGGCAGCTGTCAGAACAGC	0.547													0	0	0	0.160694	0	16	58										C	33359935	G	C	33359935	3	2	58	1	0	0	0	0	1	0	0	0	9073	1377	48	4	1182	4	LTBP1	2	33359935	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		33359935	209839438	15	16702										
AFF3	3899	broad.mit.edu	37	chr2	100623238	100623238	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ttaggagactcatcaggggcCtgatcttggccgtccattgg	13	10	3	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr2:100623238C>T	uc002tag.2	-	6	965	c.729G>A	c.(727-729)CAG>CAA	p.Q243Q	AFF3_uc002taf.2_Silent_p.Q268Q|AFF3_uc010fiq.1_Silent_p.Q243Q|AFF3_uc010yvr.1_Silent_p.Q397Q|AFF3_uc002tah.1_Silent_p.Q268Q|AFF3_uc010fir.1_Silent_p.Q320Q|AFF3_uc002tai.2_Silent_p.Q165Q	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	243					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CATCAGGGGCCTGATCTTGGC	0.572													0	0	0	0.055883	0	21	8										T	100623238	C	T	100623238	2	4	58	1	0	0	0	0	0	0	0	1	358	680	24	2		2	AFF3	2	100623238	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	67263303	100623238	142576135	16	16703										
BUB1	699	broad.mit.edu	37	chr2	111395670	111395670	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	aacaaatccaaagatggaagAtgatgacaatctggaatatt	8	5	1	4			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr2:111395670A>T	uc002tgc.2	-	25	3241	c.3129T>A	c.(3127-3129)CAT>CAA	p.H1043Q	BUB1_uc010yxh.1_Missense_Mutation_p.H1023Q|BUB1_uc010fkb.2_Missense_Mutation_p.H986Q	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	1043	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		AAGATGGAAGATGATGACAAT	0.333													0	0	0	0.150653	0	4	35										T	111395670	A	T	111395670	3	4	58	1	0	0	0	0	1	0	0	0	1570	330	12	5	132	5	BUB1	2	111395670	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	10772432	111395670	131803703	17	16704										
HDAC11	79885	broad.mit.edu	37	chr3	13522882	13522882	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gaaaatggggcaaagtgatcAatttcctaaaaggtatggaa	11	4	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:13522882A>C	uc003bxy.2	+	2	272	c.139A>C	c.(139-141)AAT>CAT	p.N47H	HDAC11_uc010heb.2_Missense_Mutation_p.N19H|HDAC11_uc011aux.1_5'UTR|HDAC11_uc003bxz.2_Missense_Mutation_p.N19H|HDAC11_uc011auy.1_Missense_Mutation_p.N19H	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	47	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						CAAAGTGATCAATTTCCTAAA	0.542													0	0	0	0.139131	0	52	149										C	13522882	A	C	13522882	3	2	58	1	0	0	0	0	1	0	0	0	7006	130	5	5	145	5	HDAC11	3	13522882	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08		13522882	184499548	18	16705										
ZNF445	353274	broad.mit.edu	37	chr3	44488285	44488285	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agtgagcctggagctctggcTgcaagcttctttgcagtctt	12	10	3	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:44488285T>G	uc003cnf.2	-	8	3226	c.2878A>C	c.(2878-2880)AGC>CGC	p.S960R	ZNF445_uc011azv.1_Missense_Mutation_p.S948R|ZNF445_uc011azw.1_Missense_Mutation_p.S960R	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	960					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GAGCTCTGGCTGCAAGCTTCT	0.478													0	0	0	0.055883	0	20	63										G	44488285	T	G	44488285	3	3	58	1	0	0	0	0	1	0	0	0	17915	1580	55	5	221	5	ZNF445	3	44488285	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	30965403	44488285	153534145	19	16706										
PDZRN3	23024	broad.mit.edu	37	chr3	73433184	73433184	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gggcgtggggctccggctccCgtcgctggctctccgctctt	15	16	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:73433184C>T	uc003dpl.1	-	10	2629	c.2533G>A	c.(2533-2535)GGG>AGG	p.G845R	PDZRN3_uc011bgh.1_Missense_Mutation_p.G502R|PDZRN3_uc010hoe.1_Missense_Mutation_p.G543R|PDZRN3_uc011bgf.1_Missense_Mutation_p.G562R|PDZRN3_uc011bgg.1_Missense_Mutation_p.G565R	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	845							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CTCCGGCTCCCGTCGCTGGCT	0.667													0	0	0	0.146539	0	14	11										T	73433184	C	T	73433184	3	4	58	1	0	0	0	0	1	0	0	0	11709	652	23	2	671	2	PDZRN3	3	73433184	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	28944899	73433184	124589246	20	16707										
PARP14	54625	broad.mit.edu	37	chr3	122446797	122446797	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gctccgtgccacacgtcaatCgaaatggctttaaccgcagc	9	14	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:122446797C>T	uc003efq.3	+	16	5139	c.5080C>T	c.(5080-5082)CGA>TGA	p.R1694*	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Nonsense_Mutation_p.R1411*	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1694	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		ACACGTCAATCGAAATGGCTT	0.507													0	0	0	0.173368	0	28	35										T	122446797	C	T	122446797	4	4	58	1	0	0	0	0	0	1	0	0	11458	876	31	1	5142	1	PARP14	3	122446797	Nonsense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	49013613	122446797	75575633	21	16708										
MYLK	4638	broad.mit.edu	37	chr3	123419212	123419212	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ggcgttgcccattggcttcaGggtctcagcaggcttggcgt	15	11	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:123419212G>A	uc003ego.2	-	18	3385	c.3103C>T	c.(3103-3105)CTG>TTG	p.L1035L	MYLK_uc011bjw.1_Silent_p.L1035L|MYLK_uc003egp.2_Silent_p.L966L|MYLK_uc003egq.2_Silent_p.L1035L|MYLK_uc003egr.2_Silent_p.L966L|MYLK_uc003egs.2_Silent_p.L859L|MYLK_uc003egt.2_Silent_p.L226L	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1035	2-4.|6 X 12 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ATTGGCTTCAGGGTCTCAGCA	0.577													0	0	0	0.139131	0	112	124										A	123419212	G	A	123419212	2	1	58	1	0	0	0	0	0	0	0	1	10056	991	35	2		2	MYLK	3	123419212	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	972415	123419212	74603218	22	16709										
ZIC4	84107	broad.mit.edu	37	chr3	147114157	147114157	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gcaggagtccattcaaaggaCggctgggggaggcctgggga	19	8	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr3:147114157C>T	uc003ewd.1	-	3	443	c.170G>A	c.(169-171)CGT>CAT	p.R57H	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.R107H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	57						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						ATTCAAAGGACGGCTGGGGGA	0.726													0	0	0	0.11911	0	12	32										T	147114157	C	T	147114157	3	4	58	1	0	0	0	0	1	0	0	0	17678	536	19	2	846	2	ZIC4	3	147114157	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	23694945	147114157	50908273	23	16710										
GABRA4	2557	broad.mit.edu	37	chr4	46930266	46930266	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	attagactttctgatttctcCatagtgtccttagataaata	5	7	2	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr4:46930266C>T	uc003gxg.2	-	9	1780	c.1641G>A	c.(1639-1641)ATG>ATA	p.M547I		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	547					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGATTTCTCCATAGTGTCCT	0.294													0	0	0	0.150653	0	3	119										T	46930266	C	T	46930266	3	4	58	1	0	0	0	0	1	0	0	0	6163	594	21	2	27	2	GABRA4	4	46930266	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		46930266	144224010	24	16711										
EXOSC9	5393	broad.mit.edu	37	chr4	122728756	122728756	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccacatgcccatttgtgtcaGttttgcctttttccagcaag	7	12	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr4:122728756G>A	uc003iea.2	+	6	692	c.584G>A	c.(583-585)AGT>AAT	p.S195N	EXOSC9_uc003idz.2_Missense_Mutation_p.S195N|EXOSC9_uc003ieb.2_Missense_Mutation_p.S179N|EXOSC9_uc010inp.1_RNA	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	195	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						ATTTGTGTCAGTTTTGCCTTT	0.368													0	0	0	0.09319	0	10	77										A	122728756	G	A	122728756	3	1	58	1	0	0	0	0	1	0	0	0	5321	1029	36	2	606	2	EXOSC9	4	122728756	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	75798490	122728756	68425520	25	16712										
ADAMTS12	81792	broad.mit.edu	37	chr5	33576989	33576989	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ggtaggactagggctgctgaTtgctggagtgcttgtgctca	16	7	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:33576989T>A	uc003jia.1	-	19	3305	c.3142A>T	c.(3142-3144)ATC>TTC	p.I1048F	ADAMTS12_uc010iuq.1_Missense_Mutation_p.I963F	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1048	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGGCTGCTGATTGCTGGAGTG	0.557										HNSCC(64;0.19)			0	0	0	0.124865	0	40	52										A	33576989	T	A	33576989	3	1	58	1	0	0	0	0	1	0	0	0	257	1493	52	5	1666	5	ADAMTS12	5	33576989	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08		33576989	147338271	26	16713										
PCDHB3	56132	broad.mit.edu	37	chr5	140482387	140482387	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cggctgtgcaggaggagcagGgcggcctcggtgggtcgctg	21	10	0	0	rs113521664		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:140482387G>T	uc003lio.2	+	1	2154	c.2154G>T	c.(2152-2154)AGG>AGT	p.R718S	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	718	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGAGCAGGGCGGCCTCGG	0.667													1	0	1.54771e-57	0.139131	1.81456e-57	90	82										T	140482387	G	T	140482387	3	4	58	1	0	0	0	0	1	0	0	0	11543	1223	43	4	2156	4	PCDHB3	5	140482387	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	106905398	140482387	40432873	27	16714										
PCDHB14	56122	broad.mit.edu	37	chr5	140604519	140604519	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cgccacagacagagactcagGcaccaacgcccaggtcaact	9	16	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:140604519G>A	uc003ljb.2	+	1	1442	c.1442G>A	c.(1441-1443)GGC>GAC	p.G481D	PCDHB14_uc011dal.1_Missense_Mutation_p.G328D	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	481	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGACTCAGGCACCAACGCC	0.647													0	0	0	0.139131	0	70	124										A	140604519	G	A	140604519	3	1	58	1	0	0	0	0	1	0	0	0	11539	1203	42	2	1444	2	PCDHB14	5	140604519	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	122132	140604519	40310741	28	16715										
WWC1	23286	broad.mit.edu	37	chr5	167835653	167835653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gctcccagacagacatctcgGgaagcgtgagtagacggggc	15	11	1	4			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr5:167835653G>A	uc003lzu.2	+	7	955	c.862G>A	c.(862-864)GGA>AGA	p.G288R	WWC1_uc003lzv.2_Missense_Mutation_p.G288R|WWC1_uc011den.1_Missense_Mutation_p.G288R|WWC1_uc003lzw.2_Missense_Mutation_p.G87R	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	288					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		AGACATCTCGGGAAGCGTGAG	0.592													0	0	0	0.160694	0	15	176										A	167835653	G	A	167835653	3	1	58	1	0	0	0	0	1	0	0	0	17408	1233	43	2	888	2	WWC1	5	167835653	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	27231134	167835653	13079607	29	16716										
FOXQ1	94234	broad.mit.edu	37	chr6	1313343	1313343	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cgccatggccatccgcgactCggcgggcgggcgcttgacgc	16	16	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:1313343C>A	uc003mtl.3	+	1	669	c.404C>A	c.(403-405)TCG>TAG	p.S135*		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	135	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ATCCGCGACTCGGCGGGCGGG	0.592													1	0	1.04594e-18	0.086207	1.20549e-18	31	25										A	1313343	C	A	1313343	4	1	58	1	0	0	0	0	0	1	0	0	6030	893	31	3	406	3	FOXQ1	6	1313343	Nonsense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		1313343	169801724	30	16717										
WRNIP1	56897	broad.mit.edu	37	chr6	2766344	2766346	+	In_Frame_Del	DEL	AGG	AGG	-													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctgggacgaggcggaggcgcAggaggaggaggaggccgtgg							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:2766344_2766346delAGG	uc003mtz.2	+	1	679_681	c.488_490delAGG	c.(487-492)CAGGAG>CAG	p.E167del	WRNIP1_uc003mua.2_In_Frame_Del_p.E167del	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	167					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				gcggaggcgcaggaggaggagga	0.374																		3	4	---	---								-	2766346	AGG	-	2766344	7	5	58	1	0	1	0	1	0	0	0	0	17400	188	7	0	490	0	WRNIP1	6	2766344	In_Frame_Del	DEL	AGG	TCGA-DK-A3IM-01A-11D-A20D-08	1453001	2766344	168348723	31	16718										
GPX6	257202	broad.mit.edu	37	chr6	28478665	28478665	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	catagatggtgcctgttaccCctttgttgcaatccacctgg	9	12	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:28478665C>G	uc011dlj.1	-	2	154	c.104G>C	c.(103-105)GGG>GCG	p.G35A	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	35					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	GCCTGTTACCCCTTTGTTGCA	0.408													0	0	0	0.139131	0	34	31										G	28478665	C	G	28478665	3	3	58	1	0	0	0	0	1	0	0	0	6744	623	22	4	577	4	GPX6	6	28478665	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	25712321	28478665	142636402	32	16719										
VPS52	6293	broad.mit.edu	37	chr6	33232186	33232186	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	atccaacccccctaggcgctGggggtcagtgcttcggacgc	13	15	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:33232186G>C	uc003odm.1	-	14	1699	c.1489C>G	c.(1489-1491)CAG>GAG	p.Q497E	VPS52_uc003odn.1_Missense_Mutation_p.Q308E	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	497					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						CCTAGGCGCTGGGGGTCAGTG	0.557													0	0	0	0.139131	0	43	51										C	33232186	G	C	33232186	3	2	58	1	0	0	0	0	1	0	0	0	17211	1357	47	4	710	4	VPS52	6	33232186	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	4753521	33232186	137882881	33	16720										
PHF3	23469	broad.mit.edu	37	chr6	64390062	64390062	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cacctcgtttaatggcacaaGgtaatcctttgagagaggtc	10	9	0	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:64390062G>A	uc003pep.1	+	2	432	c.406G>A	c.(406-408)GAA>AAA	p.E136K	PHF3_uc010kaf.1_Missense_Mutation_p.E136K|PHF3_uc003pem.2_Missense_Mutation_p.E89K|PHF3_uc010kag.1_Missense_Mutation_p.E48K|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Missense_Mutation_p.E48K|PHF3_uc011dxs.1_5'UTR|PHF3_uc003peo.2_Missense_Mutation_p.E136K	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	136					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AATGGCACAAGGTAATCCTTT	0.368													0	0	0	0.139131	0	77	73										A	64390062	G	A	64390062	3	1	58	1	0	0	0	0	1	0	0	0	11836	1014	35	2	412	2	PHF3	6	64390062	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	31157876	64390062	106725005	34	16721										
RIMS1	22999	broad.mit.edu	37	chr6	72957746	72957747	+	Nonsense_Mutation	DNP	GG	GG	CT													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcctttgaatctcagaagatGgaaaggccttccatttctgt							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:72957746_72957747GG>CT	uc003pga.2	+	12	2234_2235	c.2157_2158GG>CT	c.(2155-2160)ATGGAA>ATCTAA	p.719_720ME>I*	RIMS1_uc011dyb.1_Nonsense_Mutation_p.345_346ME>I*|RIMS1_uc003pgc.2_Nonsense_Mutation_p.345_346ME>I*|RIMS1_uc010kaq.2_Nonsense_Mutation_p.193_194ME>I*|RIMS1_uc011dyc.1_Nonsense_Mutation_p.193_194ME>I*|RIMS1_uc010kar.2_Nonsense_Mutation_p.112_113ME>I*|RIMS1_uc011dyd.1_Nonsense_Mutation_p.178_179ME>I*|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Nonsense_Mutation_p.345_346ME>I*|RIMS1_uc010kas.1_Nonsense_Mutation_p.178_179ME>I*	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	719_720					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTCAGAAGATGGAAAGGCCTTC	0.332													0	0	0	0.115264	0	22	61										CT	72957747	GG	CT	72957746	4	2	58	1	0	0	0	0	0	1	0	0	13367	1348	47	4	2366	4	RIMS1	6	72957746	Nonsense_Mutation	DNP	GG	TCGA-DK-A3IM-01A-11D-A20D-08	8567684	72957746	98157321	35	16722										
OPRM1	4988	broad.mit.edu	37	chr6	154412526	154412526	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccaacctcttccaacattgaGcaacaaaactccactcgaat	3	15	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:154412526G>A	uc003qpr.2	+	3	1320	c.1083G>A	c.(1081-1083)GAG>GAA	p.E361E	OPRM1_uc011efc.1_Silent_p.E280E|OPRM1_uc011efd.1_Silent_p.E261E|OPRM1_uc011efe.1_Silent_p.E454E|OPRM1_uc003qpn.2_Silent_p.E361E|OPRM1_uc003qpo.1_Silent_p.E361E|OPRM1_uc011eff.1_Silent_p.E361E|OPRM1_uc011efg.1_Silent_p.E361E|OPRM1_uc011efh.1_Silent_p.E361E|OPRM1_uc003qpq.1_Silent_p.E361E|OPRM1_uc003qpt.1_Silent_p.E361E|OPRM1_uc011efi.1_Silent_p.E361E|OPRM1_uc003qpp.2_RNA|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Silent_p.E261E|OPRM1_uc003qpu.2_Silent_p.E261E	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	361	Cytoplasmic (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CCAACATTGAGCAACAAAACT	0.448													0	0	0	0.150653	0	3	109										A	154412526	G	A	154412526	2	1	58	1	0	0	0	0	0	0	0	1	10887	962	34	2		2	OPRM1	6	154412526	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	81454780	154412526	16702541	36	16723										
FNDC1	84624	broad.mit.edu	37	chr6	159655154	159655154	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cttcctctgtgccaaagtggCcctcttcctccactcccagg	7	18	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:159655154C>G	uc010kjv.2	+	11	3810	c.3610C>G	c.(3610-3612)CCC>GCC	p.P1204A	FNDC1_uc010kjw.1_Missense_Mutation_p.P1089A	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1204						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCAAAGTGGCCCTCTTCCTC	0.632													0	0	0	0.038147	0	5	15										G	159655154	C	G	159655154	3	3	58	1	0	0	0	0	1	0	0	0	5968	739	26	4	3652	4	FNDC1	6	159655154	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	5242628	159655154	11459913	37	16724										
FNDC1	84624	broad.mit.edu	37	chr6	159655190	159655190	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccaggggcggcaaagacgccGatgggagcctcgccaaggaa	16	12	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:159655190G>A	uc010kjv.2	+	11	3846	c.3646G>A	c.(3646-3648)GAT>AAT	p.D1216N	FNDC1_uc010kjw.1_Missense_Mutation_p.D1101N	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1216						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAAAGACGCCGATGGGAGCCT	0.637													0	0	0	0.02938	0	6	7										A	159655190	G	A	159655190	3	1	58	1	0	0	0	0	1	0	0	0	5968	1058	37	1	3688	1	FNDC1	6	159655190	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	36	159655190	11459877	38	16725										
IGF2R	3482	broad.mit.edu	37	chr6	160517637	160517637	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tacctcttctcttggtacacCtcagccgtgtgtcctctggg	9	14	4	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr6:160517637C>T	uc003qta.2	+	45	6970	c.6822C>T	c.(6820-6822)ACC>ACT	p.T2274T		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2274	15.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CTTGGTACACCTCAGCCGTGT	0.522													0	0	0	0.132662	0	12	74										T	160517637	C	T	160517637	2	4	58	1	0	0	0	0	0	0	0	1	7576	668	24	2		2	IGF2R	6	160517637	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	862447	160517637	10597430	39	16726										
AMZ1	155185	broad.mit.edu	37	chr7	2740362	2740362	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	accggaagccccgcctggctCggaagcacatctacctacag	10	16	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:2740362C>G	uc003smr.1	+	2	638	c.277C>G	c.(277-279)CGG>GGG	p.R93G	AMZ1_uc003sms.1_Missense_Mutation_p.R93G|AMZ1_uc011jwa.1_5'Flank	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	93							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CCGCCTGGCTCGGAAGCACAT	0.642													0	0	0	0.183431	0	25	44										G	2740362	C	G	2740362	3	3	58	1	0	0	0	0	1	0	0	0	596	875	31	1	279	1	AMZ1	7	2740362	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		2740362	156398301	40	16727										
ZP3	7784	broad.mit.edu	37	chr7	76069569	76069569	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agctgttattccttgcagatAtacatcacctgccacctgaa	6	12	1	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:76069569A>G	uc003ufd.3	+	6	844	c.834A>G	c.(832-834)ATA>ATG	p.I278M	ZP3_uc003ufc.3_Missense_Mutation_p.I227M|ZP3_uc003ufe.2_Missense_Mutation_p.I186M	NM_001110354	NP_001103824	P21754	ZP3_HUMAN	zona pellucida glycoprotein 3 isoform 1	278	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|blastocyst formation|egg coat formation|humoral immune response mediated by circulating immunoglobulin|intracellular protein transport|negative regulation of binding of sperm to zona pellucida|negative regulation of transcription, DNA-dependent|oocyte development|phosphatidylinositol-mediated signaling|positive regulation of acrosomal vesicle exocytosis|positive regulation of acrosome reaction|positive regulation of antral ovarian follicle growth|positive regulation of calcium ion import|positive regulation of calcium ion transport via store-operated calcium channel activity|positive regulation of humoral immune response|positive regulation of interferon-gamma production|positive regulation of interleukin-4 production|positive regulation of leukocyte migration|positive regulation of ovarian follicle development|positive regulation of phosphatidylinositol biosynthetic process|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of T cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of type IV hypersensitivity|protein kinase C signaling cascade	endoplasmic reticulum|extracellular space|Golgi apparatus|integral to membrane|multivesicular body|outer acrosomal membrane|perinuclear region of cytoplasm|plasma membrane|proteinaceous extracellular matrix	acrosin binding|manganese ion transmembrane transporter activity|receptor activity|sugar binding				0						CCTTGCAGATATACATCACCT	0.502													0	0	0	0.058154	0	7	1										G	76069569	A	G	76069569	3	3	58	1	0	0	0	0	1	0	0	0	18214	439	16	5	856	5	ZP3	7	76069569	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	73329207	76069569	83069094	41	16728										
TRRAP	8295	broad.mit.edu	37	chr7	98592453	98592453	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	accctgtctttcagaagctgAaaggccagttcacgacgggt	11	11	3	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:98592453A>G	uc003upp.2	+	66	10458	c.10249A>G	c.(10249-10251)AAA>GAA	p.K3417E	TRRAP_uc011kis.1_Missense_Mutation_p.K3388E|TRRAP_uc003upr.2_Missense_Mutation_p.K3123E	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3417					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCAGAAGCTGAAAGGCCAGTT	0.552													0	0	0	0.139131	0	80	19										G	98592453	A	G	98592453	3	3	58	1	0	0	0	0	1	0	0	0	16598	247	9	5	10416	5	TRRAP	7	98592453	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	22522884	98592453	60546210	42	16729										
TRIM56	81844	broad.mit.edu	37	chr7	100730858	100730858	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgctggacctggtgaaggccCgggcctgtggagacctgcgt	17	11	0	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:100730858C>T	uc003uxq.2	+	3	496	c.265C>T	c.(265-267)CGG>TGG	p.R89W	TRIM56_uc003uxr.2_Missense_Mutation_p.R89W	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	89					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					GGTGAAGGCCCGGGCCTGTGG	0.706													0	0	0	0.021553	0	5	61										T	100730858	C	T	100730858	3	4	58	1	0	0	0	0	1	0	0	0	16527	643	23	2	267	2	TRIM56	7	100730858	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2138405	100730858	58407805	43	16730										
OR2F1	26211	broad.mit.edu	37	chr7	143657849	143657849	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	attttcacttacatccagccCcactccagtccctctgtcct	3	18	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:143657849C>G	uc003wds.1	+	1	830	c.786C>G	c.(784-786)CCC>CCG	p.P262P		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					ACATCCAGCCCCACTCCAGTC	0.473													0	0	0	0.150653	0	4	63										G	143657849	C	G	143657849	2	3	58	1	0	0	0	0	0	0	0	1	10996	610	22	4		4	OR2F1	7	143657849	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	42926991	143657849	15480814	44	16731										
KRBA1	84626	broad.mit.edu	37	chr7	149427255	149427255	+	Frame_Shift_Del	DEL	C	C	-													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agggtctgcccccaagccctCcccgctgcactgcctggaga							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr7:149427255delC	uc003wfz.2	+	15	2228	c.1829delC	c.(1828-1830)TCCfs	p.S610fs	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Frame_Shift_Del_p.S217fs	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	610	Pro-rich.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCCAAGCCCTCCCCGCTGCAC	0.567																		2	4	---	---								-	149427255	C	-	149427255	7	5	58	1	0	1	0	1	0	0	0	0	8439	855	30	0	1878	0	KRBA1	7	149427255	Frame_Shift_Del	DEL	C	TCGA-DK-A3IM-01A-11D-A20D-08	5769406	149427255	9711408	45	16732										
CSMD1	64478	broad.mit.edu	37	chr8	2830727	2830727	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agctggtgccccatttcacaGgagaagcggagaagactctt	12	10	2	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:2830727G>T	uc011kwk.1	-	57	9228	c.8838C>A	c.(8836-8838)TCC>TCA	p.S2946S	CSMD1_uc011kwj.1_Silent_p.S2275S|CSMD1_uc010lrg.2_Silent_p.S956S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2946	Extracellular (Potential).|Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCATTTCACAGGAGAAGCGGA	0.552													1	0	1.23904e-05	0.014758	1.32685e-05	5	103										T	2830727	G	T	2830727	2	4	58	1	0	0	0	0	0	0	0	1	3944	987	35	4		4	CSMD1	8	2830727	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		2830727	143533295	46	16733										
KIAA1967	57805	broad.mit.edu	37	chr8	22475219	22475219	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctttctgtagcaggagcaaaGctggaggattcggaggtccg	15	8	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:22475219G>A	uc003xch.2	+	16	2138	c.2001G>A	c.(1999-2001)AAG>AAA	p.K667K	KIAA1967_uc003xci.2_Silent_p.K667K|KIAA1967_uc003xcj.1_Silent_p.K336K	NM_199205	NP_954675	Q8N163	K1967_HUMAN	p30 DBC protein	667					apoptosis|positive regulation of apoptosis	mitochondrial matrix|nucleus	enzyme binding|enzyme inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00593)|Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CAGGAGCAAAGCTGGAGGATT	0.532													0	0	0	0.021553	0	6	91										A	22475219	G	A	22475219	2	1	58	1	0	0	0	0	0	0	0	1	8265	962	34	2		2	KIAA1967	8	22475219	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	19644492	22475219	123888803	47	16734										
NUDCD1	84955	broad.mit.edu	37	chr8	110293311	110293312	+	Frame_Shift_Del	DEL	TG	TG	-													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgatgtgatcaggcaaaaacTgtatttgaatgtcctcctta					rs143668430		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:110293311_110293312delTG	uc003ynb.3	-	6	1024_1025	c.913_914delCA	c.(913-915)CAGfs	p.Q305fs	NUDCD1_uc003yna.2_Frame_Shift_Del_p.Q276fs|NUDCD1_uc010mcl.2_Frame_Shift_Del_p.Q218fs|NUDCD1_uc010mcm.1_Frame_Shift_Del_p.Q218fs	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	305	CS.									ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			AGGCAAAAACTGTATTTGAATG	0.371																		82	10	---	---								-	110293312	TG	-	110293311	7	5	58	1	0	1	0	1	0	0	0	0	10722	1580	55	0	857	0	NUDCD1	8	110293311	Frame_Shift_Del	DEL	TG	TCGA-DK-A3IM-01A-11D-A20D-08	87818092	110293311	36070711	48	16735										
ASAP1	50807	broad.mit.edu	37	chr8	131130435	131130435	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tacaaggaagtcaaccaaatGgagagatgtctgatctgcag	11	7	3	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr8:131130435G>A	uc003yta.1	-	19	1880	c.1852C>T	c.(1852-1854)CAT>TAT	p.H618Y	ASAP1_uc003ysz.1_Missense_Mutation_p.H429Y|ASAP1_uc011liw.1_Missense_Mutation_p.H611Y	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	618	ANK 1.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TCAACCAAATGGAGAGATGTC	0.393													0	0	0	0.150653	0	3	81										A	131130435	G	A	131130435	3	1	58	1	0	0	0	0	1	0	0	0	1010	1348	47	2	1581	2	ASAP1	8	131130435	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	20837124	131130435	15233587	49	16736										
KDM4C	23081	broad.mit.edu	37	chr9	7103807	7103807	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gctgctggggtactgatggaGcctgatgactggccttatgt	15	8	0	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:7103807G>A	uc003zkh.2	+	18	3127	c.2547G>A	c.(2545-2547)GAG>GAA	p.E849E	KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.E849E|KDM4C_uc011lmk.1_Silent_p.E594E|KDM4C_uc011lml.1_Silent_p.E536E	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	849	PHD-type 2.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TACTGATGGAGCCTGATGACT	0.468													0	0	0	0.163468	0	28	59										A	7103807	G	A	7103807	2	1	58	1	0	0	0	0	0	0	0	1	8130	962	34	2		2	KDM4C	9	7103807	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		7103807	134109624	50	16737										
FAM75C1	441452	broad.mit.edu	37	chr9	90536086	90536086	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ggttggctttaccctctaggGtccaaaaatctcaggacgtc	10	11	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:90536086G>A	uc010mqi.2	+	4	1293	c.1264G>A	c.(1264-1266)GTC>ATC	p.V422I	FAM75C1_uc004apq.3_Missense_Mutation_p.V405I	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ACCCTCTAGGGTCCAAAAATC	0.478													0	0	0	0.064281	0	26	151										A	90536086	G	A	90536086	3	1	58	1	0	0	0	0	1	0	0	0	5623	1261	44	2	1278	2	FAM75C1	9	90536086	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	83432279	90536086	50677345	51	16738										
IKBKAP	8518	broad.mit.edu	37	chr9	111665223	111665223	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	aatagccagagaaggtgactCtgcaagattcacagatctag	10	8	3	4			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:111665223C>A	uc004bdm.3	-	16	2271	c.1751_splice	c.e16-1	p.E584_splice	IKBKAP_uc004bdl.2_Splice_Site_p.E235_splice|IKBKAP_uc011lwc.1_Splice_Site_p.E470_splice|IKBKAP_uc010mtq.2_Splice_Site_p.E235_splice	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene						immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						GAAGGTGACTCTGCAAGATTC	0.413													1	0	1.50039e-11	0.062417	1.70044e-11	20	48										A	111665223	C	A	111665223	5	1	58	1	0	0	0	0	0	0	1	0	7610	927	32	3	2336	3	IKBKAP	9	111665223	Splice_Site	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	21129137	111665223	29548208	52	16739										
SEC16A	9919	broad.mit.edu	37	chr9	139369743	139369743	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cggctctgcaccggggccgcCgagcttgggttccgtgactg	16	14	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr9:139369743C>T	uc004chx.2	-	3	2634	c.2325G>A	c.(2323-2325)TCG>TCA	p.S775S	SEC16A_uc004chv.3_Silent_p.S402S|SEC16A_uc004chw.2_Silent_p.S775S|SEC16A_uc010nbn.2_Silent_p.S775S|SEC16A_uc010nbo.1_Silent_p.S775S	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	597					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CCGGGGCCGCCGAGCTTGGGT	0.607													0	0	0	0.047766	0	7	56										T	139369743	C	T	139369743	2	4	58	1	0	0	0	0	0	0	0	1	13986	639	23	2		2	SEC16A	9	139369743	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	27704520	139369743	1843688	53	16740										
KLF6	1316	broad.mit.edu	37	chr10	3823885	3823885	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gagcttttggtgtaaactttCctgcagccgttaaagtggca	11	8	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:3823885C>T	uc001iha.2	-	2	891	c.624G>A	c.(622-624)AGG>AGA	p.R208R	KLF6_uc010qaj.1_Silent_p.R208R|KLF6_uc010qak.1_Intron|KLF6_uc010qal.1_Intron|KLF6_uc001ihb.2_Silent_p.R208R	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	208	C2H2-type 1.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		TGTAAACTTTCCTGCAGCCGT	0.657											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.150653	0	4	56										T	3823885	C	T	3823885	2	4	58	1	0	0	0	0	0	0	0	1	8350	854	30	1		1	KLF6	10	3823885	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		3823885	131710862	54	16741										
KLF6	1316	broad.mit.edu	37	chr10	3824277	3824277	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	actggaagatatcttcagttCggattcctcctttttctccc	6	12	3	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:3824277C>A	uc001iha.2	-	2	499	c.232G>T	c.(232-234)GAA>TAA	p.E78*	KLF6_uc010qaj.1_Nonsense_Mutation_p.E78*|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Nonsense_Mutation_p.E78*|KLF6_uc001ihb.2_Nonsense_Mutation_p.E78*	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	78					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		ATCTTCAGTTCGGATTCCTCC	0.483											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00278032	0.076483	0.00288644	23	159										A	3824277	C	A	3824277	4	1	58	1	0	0	0	0	0	1	0	0	8350	893	31	3	631	3	KLF6	10	3824277	Nonsense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	392	3824277	131710470	55	16742										
ERCC6	2074	broad.mit.edu	37	chr10	50669504	50669504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gagcctcagtgctttcagggCatcctgggccactcggttgg	14	12	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:50669504C>T	uc001jhs.3	-	19	4031	c.3877G>A	c.(3877-3879)GCC>ACC	p.A1293T	ERCC6_uc009xod.2_Missense_Mutation_p.A453T|ERCC6_uc010qgr.1_Missense_Mutation_p.A663T|ERCC6_uc001jhr.3_Missense_Mutation_p.A661T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1293					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GCTTTCAGGGCATCCTGGGCC	0.592								Direct_reversal_of_damage|NER					0	0	0	0.069288	0	21	28										T	50669504	C	T	50669504	3	4	58	1	0	0	0	0	1	0	0	0	5217	710	25	2	616	2	ERCC6	10	50669504	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	46845227	50669504	84865243	56	16743										
SH2D4B	387694	broad.mit.edu	37	chr10	82403797	82403797	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agttacttcaggaaccctgcGgacagagggacagcccacca	11	13	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:82403797G>A	uc001kck.1	+	7	1464	c.1034G>A	c.(1033-1035)CGG>CAG	p.R345Q	SH2D4B_uc001kcl.1_Missense_Mutation_p.R297Q|SH2D4B_uc001kcm.1_Missense_Mutation_p.G166R|SH2D4B_uc001kcn.1_RNA	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	Error:Variant_position_missing_in_Q5SQS7_after_alignment											0			Colorectal(32;0.229)			GGAACCCTGCGGACAGAGGGA	0.373													0	0	0	0.062417	0	14	59										A	82403797	G	A	82403797	3	1	58	1	0	0	0	0	1	0	0	0	14236	1116	39	2	1104	2	SH2D4B	10	82403797	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	31734293	82403797	53130950	57	16744										
NRG3	10718	broad.mit.edu	37	chr10	84498404	84498404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgattccatcttatcggatcCaagtaggtcaagcatttttc	7	9	2	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:84498404C>T	uc001kco.2	+	3	1052	c.1025C>T	c.(1024-1026)CCA>CTA	p.P342L	NRG3_uc010qlz.1_Missense_Mutation_p.P342L|NRG3_uc001kcp.2_Missense_Mutation_p.P121L|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	342	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TTATCGGATCCAAGTAGGTCA	0.393													0	0	0	0.014758	0	4	44										T	84498404	C	T	84498404	3	4	58	1	0	0	0	0	1	0	0	0	10649	594	21	2	1203	2	NRG3	10	84498404	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2094607	84498404	51036343	58	16745										
PIK3AP1	118788	broad.mit.edu	37	chr10	98411088	98411088	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tattgttcttcagggattcgGttagcagtttatcaagggtc	11	6	3	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:98411088G>C	uc001kmq.2	-	6	1033	c.905C>G	c.(904-906)ACC>AGC	p.T302S	PIK3AP1_uc001kmp.2_Missense_Mutation_p.T124S	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	302	DBB.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CAGGGATTCGGTTAGCAGTTT	0.428													0	0	0	0.160694	0	16	36										C	98411088	G	C	98411088	3	2	58	1	0	0	0	0	1	0	0	0	11908	1261	44	4	1560	4	PIK3AP1	10	98411088	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	13912684	98411088	37123659	59	16746										
RRP12	23223	broad.mit.edu	37	chr10	99133483	99133483	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cttgtgcagaacccaggcagGagtgtccacatctggagaag	13	10	1	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr10:99133483G>A	uc001knf.2	-	17	2014	c.1875C>T	c.(1873-1875)CTC>CTT	p.L625L	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Silent_p.L343L|RRP12_uc010qou.1_Silent_p.L564L|RRP12_uc009xvn.2_Silent_p.L525L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	625						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		ACCCAGGCAGGAGTGTCCACA	0.622													0	0	0	0.080422	0	34	12										A	99133483	G	A	99133483	2	1	58	1	0	0	0	0	0	0	0	1	13686	1161	41	1		1	RRP12	10	99133483	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	722395	99133483	36401264	60	16747										
OR9Q2	219957	broad.mit.edu	37	chr11	57958327	57958327	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ggccatcatggcctatgaccGctacacggccgtgtgccagc	12	15	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:57958327G>A	uc010rka.1	+	1	365	c.365G>A	c.(364-366)CGC>CAC	p.R122H		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				GCCTATGACCGCTACACGGCC	0.567													0	0	0	0.139131	0	45	88										A	57958327	G	A	57958327	3	1	58	1	0	0	0	0	1	0	0	0	11256	1087	38	2	367	2	OR9Q2	11	57958327	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		57958327	77048189	61	16748										
MPEG1	219972	broad.mit.edu	37	chr11	58980208	58980208	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agccccctccaggtaggactTccaggacaggtagtttcaag	11	12	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:58980208T>C	uc001nnu.3	-	1	287	c.131A>G	c.(130-132)GAA>GGA	p.E44G		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	44	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				AGGTAGGACTTCCAGGACAGG	0.522													0	0	0	0.014758	0	5	244										C	58980208	T	C	58980208	3	2	58	1	0	0	0	0	1	0	0	0	9723	1783	62	5	2023	5	MPEG1	11	58980208	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	1021881	58980208	76026308	62	16749										
SCGB1D1	10648	broad.mit.edu	37	chr11	61959667	61959667	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	aagatggaagtgaagaaatgCgtggatacgatggcctatga	14	4	0	4			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:61959667C>T	uc001nsz.1	+	2	242	c.195C>T	c.(193-195)TGC>TGT	p.C65C		NM_006552	NP_006543	O95968	SG1D1_HUMAN	lipophilin A precursor	65						extracellular space	binding			skin(1)	1						TGAAGAAATGCGTGGATACGA	0.443													0	0	0	0.139131	0	83	65										T	61959667	C	T	61959667	2	4	58	1	0	0	0	0	0	0	0	1	13896	776	27	2		2	SCGB1D1	11	61959667	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2979459	61959667	73046849	63	16750										
GANAB	23193	broad.mit.edu	37	chr11	62393905	62393905	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccatcatccagaaagagctcTccttgagctgtaccctgagc	8	14	2	4			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:62393905T>A	uc001nub.2	-	22	2559	c.2526A>T	c.(2524-2526)GGA>GGT	p.G842G	GANAB_uc001ntz.2_Silent_p.G29G|GANAB_uc001nua.2_Silent_p.G864G|GANAB_uc001nuc.2_Silent_p.G745G|GANAB_uc010rma.1_Silent_p.G750G|GANAB_uc010rmb.1_Silent_p.G728G	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	842					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GAAAGAGCTCTCCTTGAGCTG	0.552													0	0	0	0.074837	0	29	79										A	62393905	T	A	62393905	2	1	58	1	0	0	0	0	0	0	0	1	6233	1538	54	5		5	GANAB	11	62393905	Silent	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	434238	62393905	72612611	64	16751										
PLCB3	5331	broad.mit.edu	37	chr11	64033975	64033975	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gctcccgtgcagggaactgaCggagattaaccgtcggcaca	13	12	0	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:64033975C>A	uc001nzb.2	+	29	3365	c.3365C>A	c.(3364-3366)ACG>AAG	p.T1122K	PLCB3_uc009ypg.1_Missense_Mutation_p.T1122K|PLCB3_uc009yph.1_Missense_Mutation_p.T1055K|PLCB3_uc009ypi.2_Missense_Mutation_p.T1122K	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1122					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGGGAACTGACGGAGATTAAC	0.652													1	0	6.21321e-17	0.076483	7.10081e-17	20	90										A	64033975	C	A	64033975	3	1	58	1	0	0	0	0	1	0	0	0	12029	536	19	4	3479	4	PLCB3	11	64033975	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	1640070	64033975	70972541	65	16752										
KDELC2	143888	broad.mit.edu	37	chr11	108357060	108357060	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctggagattgatgctgggaaAggaagcaaaatcttttgcaa	12	5	1	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr11:108357060A>G	uc001pkj.2	-	3	574	c.508T>C	c.(508-510)TTT>CTT	p.F170L	KDELC2_uc001pki.2_Missense_Mutation_p.F114L	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	170						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		ATGCTGGGAAAGGAAGCAAAA	0.453													0	0	0	0.150653	0	4	63										G	108357060	A	G	108357060	3	3	58	1	0	0	0	0	1	0	0	0	8118	72	3	5	1039	5	KDELC2	11	108357060	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	44323085	108357060	26649456	66	16753										
ACRBP	84519	broad.mit.edu	37	chr12	6756060	6756060	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cggcaggtagtctctgccttCcaggttggagtcagcagtgc	14	11	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:6756060C>A	uc001qpu.1	-	2	210	c.162G>T	c.(160-162)TGG>TGT	p.W54C	ACRBP_uc010sfg.1_Missense_Mutation_p.W54C	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	54						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						TCTCTGCCTTCCAGGTTGGAG	0.602													1	0	0.00909568	0.150653	0.00923144	4	78										A	6756060	C	A	6756060	3	1	58	1	0	0	0	0	1	0	0	0	170	856	30	3	1505	3	ACRBP	12	6756060	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		6756060	127095835	67	16754										
IFLTD1	160492	broad.mit.edu	37	chr12	25672949	25672949	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgaacatctgttaaattcaaCgtcagcatctaatttttccc	4	10	4	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:25672949C>T	uc001rgs.2	-	6	946	c.796G>A	c.(796-798)GTT>ATT	p.V266I	IFLTD1_uc001rgt.1_Missense_Mutation_p.V169I|IFLTD1_uc010sji.1_Missense_Mutation_p.V287I|IFLTD1_uc010sjj.1_Missense_Mutation_p.V203I|IFLTD1_uc009zjc.2_Missense_Mutation_p.V247I	NM_152590	NP_689803	Q8N9Z9	ILFT1_HUMAN	intermediate filament tail domain containing 1	266						intermediate filament	structural molecule activity			ovary(2)|central_nervous_system(1)	3	all_lung(3;2.75e-22)|Lung NSC(3;1.77e-21)|all_hematologic(7;0.00656)|Colorectal(261;0.0847)					TTAAATTCAACGTCAGCATCT	0.373													0	0	0	0.153744	0	29	34										T	25672949	C	T	25672949	3	4	58	1	0	0	0	0	1	0	0	0	7530	536	19	2	382	2	IFLTD1	12	25672949	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	18916889	25672949	108178946	68	16755										
PTHLH	5744	broad.mit.edu	37	chr12	28116292	28116292	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gcctgttaccgtgaatcgagCtccagcgacgttgtggaggt	14	10	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:28116292C>T	uc001rik.2	-	3	816	c.513G>A	c.(511-513)GAG>GAA	p.E171E	PTHLH_uc001ril.2_Silent_p.E171E|PTHLH_uc001rim.2_Silent_p.E171E|PTHLH_uc001rin.2_Silent_p.E171E	NM_198966	NP_945317	P12272	PTHR_HUMAN	parathyroid hormone-like hormone isoform 1	171					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)	1	Lung SC(9;0.184)					GTGAATCGAGCTCCAGCGACG	0.582													0	0	0	0.069288	0	17	33										T	28116292	C	T	28116292	2	4	58	1	0	0	0	0	0	0	0	1	12761	796	28	2		2	PTHLH	12	28116292	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2443343	28116292	105735603	69	16756										
MLL2	8085	broad.mit.edu	37	chr12	49424741	49424741	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctccttccgcagcttctttcGggagctcaccaacctgtcgc	8	17	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:49424741G>A	uc001rta.3	-	40	13606	c.13606C>T	c.(13606-13608)CGA>TGA	p.R4536*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4536					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCTTCTTTCGGGAGCTCACC	0.592			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.058154	0	7	25										A	49424741	G	A	49424741	4	1	58	1	0	0	0	0	0	1	0	0	9621	1124	39	2	3067	2	MLL2	12	49424741	Nonsense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	21308449	49424741	84427154	70	16757										
FAM19A2	338811	broad.mit.edu	37	chr12	62148677	62148677	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cacacatgatggagcagctcGcgtggtgcctgccacctgcc	12	15	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:62148677G>A	uc001sqw.2	-	3	1748	c.235C>T	c.(235-237)CGA>TGA	p.R79*	FAM19A2_uc001sqv.2_RNA|FAM19A2_uc001sqx.2_Nonsense_Mutation_p.R79*|FAM19A2_uc001sqy.2_RNA	NM_178539	NP_848634	Q8N3H0	F19A2_HUMAN	family with sequence similarity 19 (chemokine	79						cytoplasm				ovary(1)	1			GBM - Glioblastoma multiforme(1;0.00484)	GBM - Glioblastoma multiforme(3;0.02)		GGAGCAGCTCGCGTGGTGCCT	0.502													0	0	0	0.153744	0	25	17										A	62148677	G	A	62148677	4	1	58	1	0	0	0	0	0	1	0	0	5532	1095	38	2	172	2	FAM19A2	12	62148677	Nonsense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	12723936	62148677	71703218	71	16758										
POLR3B	55703	broad.mit.edu	37	chr12	106824210	106824210	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctcgctccctccagccatctCagtggggaatgctgtgtcct	10	15	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:106824210C>A	uc001tlp.2	+	14	1645	c.1423C>A	c.(1423-1425)CAG>AAG	p.Q475K	POLR3B_uc001tlq.2_Missense_Mutation_p.Q417K	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	475					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CCAGCCATCTCAGTGGGGAAT	0.493													1	0	2.7689e-08	0.02938	3.01256e-08	4	114										A	106824210	C	A	106824210	3	1	58	1	0	0	0	0	1	0	0	0	12229	827	29	3	1477	3	POLR3B	12	106824210	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	44675533	106824210	27027685	72	16759										
CUX2	23316	broad.mit.edu	37	chr12	111786052	111786052	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgcagcggcggcatgagaagAtggccaatctgaacaacatc	12	10	1	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:111786052A>G	uc001tsa.1	+	22	4537	c.4384A>G	c.(4384-4386)ATG>GTG	p.M1462V		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1462						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GCATGAGAAGATGGCCAATCT	0.612													0	0	0	0.131918	0	39	220										G	111786052	A	G	111786052	3	3	58	1	0	0	0	0	1	0	0	0	4065	333	12	5	4470	5	CUX2	12	111786052	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	4961842	111786052	22065843	73	16760										
MLEC	9761	broad.mit.edu	37	chr12	121125148	121125150	+	In_Frame_Del	DEL	CTG	CTG	-													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccgctgtggcgctcctgcgaCtgctgctgctgctgctgccg							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:121125148_121125150delCTG	uc001tyy.1	+	1	200_202	c.49_51delCTG	c.(49-51)CTGdel	p.L22del		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	22					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						gctcctgcgactgctgctgctgc	0.517																		2	4	---	---								-	121125150	CTG	-	121125148	7	5	58	1	0	1	0	1	0	0	0	0	9613	564	20	0	51	0	MLEC	12	121125148	In_Frame_Del	DEL	CTG	TCGA-DK-A3IM-01A-11D-A20D-08	9339096	121125148	12726747	74	16761										
DNAH10	196385	broad.mit.edu	37	chr12	124354930	124354930	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	caggtcaacttccaaccttgTatgactttcattttgataac	5	10	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr12:124354930T>C	uc001uft.3	+	43	7208	c.7183T>C	c.(7183-7185)TAT>CAT	p.Y2395H		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2395					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCCAACCTTGTATGACTTTCA	0.388													0	0	0	0.049695	0	20	21										C	124354930	T	C	124354930	3	2	58	1	0	0	0	0	1	0	0	0	4598	1638	57	5	7353	5	DNAH10	12	124354930	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	3229782	124354930	9496965	75	16762										
POLR1D	51082	broad.mit.edu	37	chr13	28197152	28197152	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	taccctaggaaattctctacGttacatgatcatgaagaacc	6	10	2	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:28197152G>C	uc010tdm.1	+	3	1197	c.167G>C	c.(166-168)CGT>CCT	p.R56P	LNX2_uc001url.3_5'Flank|LNX2_uc001urm.1_5'Flank|POLR1D_uc010aam.2_Intron|POLR1D_uc001urq.2_Intron|POLR1D_uc001uro.2_Missense_Mutation_p.R56P|POLR1D_uc001urp.2_Intron	NM_015972	NP_057056	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D isoform 1	56			R -> C (in TCS2).		termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		AATTCTCTACGTTACATGATC	0.453													0	0	0	0.049695	0	17	52										C	28197152	G	C	28197152	3	2	58	1	0	0	0	0	1	0	0	0	12212	1145	40	4	173	4	POLR1D	13	28197152	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		28197152	86972726	76	16763										
SLC7A1	6541	broad.mit.edu	37	chr13	30091860	30091860	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gcttgccaattcattttggtCtgctggatctaactcgtcgg	10	10	3	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:30091860C>T	uc001uso.2	-	10	1747	c.1360G>A	c.(1360-1362)GAC>AAC	p.D454N		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	454	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCATTTTGGTCTGCTGGATCT	0.493													0	0	0	0.108266	0	24	85										T	30091860	C	T	30091860	3	4	58	1	0	0	0	0	1	0	0	0	14692	913	32	1	545	1	SLC7A1	13	30091860	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	1894708	30091860	85078018	77	16764										
BRCA2	675	broad.mit.edu	37	chr13	32910615	32910615	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tattaccccagaagctgattCtctgtcatgcctgcaggaag	9	11	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:32910615C>A	uc001uub.1	+	11	2350	c.2123C>A	c.(2122-2124)TCT>TAT	p.S708Y		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	708	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GAAGCTGATTCTCTGTCATGC	0.358			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			1	0	3.86212e-05	0.069234	4.1035e-05	11	32										A	32910615	C	A	32910615	3	1	58	1	0	0	0	0	1	0	0	0	1499	913	32	3	2161	3	BRCA2	13	32910615	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2818755	32910615	82259263	78	16765										
SLC25A30	253512	broad.mit.edu	37	chr13	45985521	45985522	+	Frame_Shift_Ins	INS	-	-	C													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcagcagtgatggaggccagINSccccccgtacacaaacggct							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:45985521_45985522insC	uc001vag.2	-	2	176_177	c.39_40insG	c.(37-42)GGGCTGfs	p.G13fs	SLC25A30_uc010tfs.1_5'UTR|SLC25A30_uc001vah.2_5'UTR|SLC25A30_uc010tft.1_Intron	NM_001010875	NP_001010875	Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	13_14	Solcar 1.|Helical; Name=1; (Potential).				mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		ATGGAGGCCAGCCCCCCGTACA	0.495																		59	24	---	---								C	45985522	-	C	45985521	7	5	58	1	0	1	1	0	0	0	0	0	14494	962	34	0	871	0	SLC25A30	13	45985521	Frame_Shift_Ins	INS	-	TCGA-DK-A3IM-01A-11D-A20D-08	13074906	45985521	69184357	79	16766										
FGF14	2259	broad.mit.edu	37	chr13	103053996	103053996	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cataataataatttgaaatcAgttctcctgaagaggggcac	8	7	2	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr13:103053996A>T	uc001vpf.2	-	1	129	c.33T>A	c.(31-33)ACT>ACA	p.T11T		NM_175929	NP_787125	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1B	Error:Variant_position_missing_in_Q92915_after_alignment					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTTGAAATCAGTTCTCCTGA	0.413													0	0	0	0.074837	0	30	3										T	103053996	A	T	103053996	2	4	58	1	0	0	0	0	0	0	0	1	5843	175	7	5		5	FGF14	13	103053996	Silent	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	57068475	103053996	12115882	80	16767										
PTGDR	5729	broad.mit.edu	37	chr14	52735003	52735003	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctggtggccccggtggtgagCgccttctccctggctttctg	14	14	2	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr14:52735003C>A	uc001wzq.2	+	1	573	c.471C>A	c.(469-471)AGC>AGA	p.S157R		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	157	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CGGTGGTGAGCGCCTTCTCCC	0.637													1	0	0.00024832	0.150653	0.000259781	3	55										A	52735003	C	A	52735003	3	1	58	1	0	0	0	0	1	0	0	0	12741	767	27	4	473	4	PTGDR	14	52735003	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		52735003	54614537	81	16768										
AHNAK2	113146	broad.mit.edu	37	chr14	105416701	105416701	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcttcaggtccccctgcatgGaggggaggctcacatcagct	12	13	4	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr14:105416701G>T	uc010axc.1	-	7	5207	c.5087C>A	c.(5086-5088)TCC>TAC	p.S1696Y	AHNAK2_uc001ypx.2_Missense_Mutation_p.S1596Y	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1696						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCTGCATGGAGGGGAGGCT	0.612													1	0	6.72482e-11	0.132662	7.55848e-11	7	272										T	105416701	G	T	105416701	3	4	58	1	0	0	0	0	1	0	0	0	415	1174	41	3	12304	3	AHNAK2	14	105416701	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	52681698	105416701	1932839	82	16769										
OCA2	4948	broad.mit.edu	37	chr15	28231744	28231744	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	catacctacctttacagcacAataatcgaaaaatcccgttt	3	12	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr15:28231744A>G	uc001zbh.3	-	12	1338	c.1228T>C	c.(1228-1230)TGT>CGT	p.C410R	OCA2_uc010ayv.2_Missense_Mutation_p.C386R	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	410	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TTTACAGCACAATAATCGAAA	0.284									Oculocutaneous_Albinism				0	0	0	0.139131	0	63	23										G	28231744	A	G	28231744	3	3	58	1	0	0	0	0	1	0	0	0	10815	130	5	5	1340	5	OCA2	15	28231744	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08		28231744	74299648	83	16770										
MYO5A	4644	broad.mit.edu	37	chr15	52662482	52662482	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ttcctgcagactaaggacccGcccagtggcaactttcgctt	9	14	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr15:52662482G>A	uc002aby.2	-	22	3194	c.2950C>T	c.(2950-2952)CGG>TGG	p.R984W	MYO5A_uc002abx.3_Missense_Mutation_p.R984W|MYO5A_uc010uge.1_Missense_Mutation_p.R853W	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	984	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTAAGGACCCGCCCAGTGGCA	0.448													0	0	0	0.11126	0	41	7										A	52662482	G	A	52662482	3	1	58	1	0	0	0	0	1	0	0	0	10078	1086	38	2	2697	2	MYO5A	15	52662482	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	24430738	52662482	49868910	84	16771										
CCDC78	124093	broad.mit.edu	37	chr16	775562	775562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cagctccagctccagtacccGgctctccagccgaaggatct	9	17	2	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr16:775562G>A	uc002cjg.2	-	4	392	c.286C>T	c.(286-288)CGG>TGG	p.R96W	CCDC78_uc002cjf.2_5'Flank|CCDC78_uc002cji.3_Missense_Mutation_p.R170W|CCDC78_uc002cjj.3_Intron|CCDC78_uc002cjh.2_5'UTR|CCDC78_uc010uuo.1_Missense_Mutation_p.R96W|CCDC78_uc002cjk.2_Missense_Mutation_p.R96W|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	96	Potential.									central_nervous_system(1)	1		Hepatocellular(780;0.0218)				TCCAGTACCCGGCTCTCCAGC	0.662													0	0	0	0.080422	0	30	2										A	775562	G	A	775562	3	1	58	1	0	0	0	0	1	0	0	0	2852	1115	39	2	1074	2	CCDC78	16	775562	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		775562	89579191	85	16772										
SH2B1	25970	broad.mit.edu	37	chr16	28877696	28877696	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gtcgccacccatcctggctcCcctgagccctggtgcggaga	12	17	0	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr16:28877696C>T	uc002dri.2	+	4	720	c.281C>T	c.(280-282)CCC>CTC	p.P94L	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.P94L|SH2B1_uc002drk.2_Missense_Mutation_p.P94L|SH2B1_uc002drl.2_Missense_Mutation_p.P94L|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.P94L|SH2B1_uc002drm.2_Missense_Mutation_p.P94L	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	94	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Interaction with RAC1 (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						ATCCTGGCTCCCCTGAGCCCT	0.652													0	0	0	0.160694	0	15	16										T	28877696	C	T	28877696	3	4	58	1	0	0	0	0	1	0	0	0	14227	623	22	2	283	2	SH2B1	16	28877696	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	28102134	28877696	61477057	86	16773										
ATMIN	23300	broad.mit.edu	37	chr16	81078139	81078139	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcaaacggacttcttactcgCagatacctctgctcagtcct	6	14	4	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr16:81078139C>G	uc002ffz.1	+	4	2054	c.2036C>G	c.(2035-2037)GCA>GGA	p.A679G	ATMIN_uc002fga.2_Missense_Mutation_p.A521G|ATMIN_uc010vnn.1_Missense_Mutation_p.A450G|ATMIN_uc002fgb.1_Missense_Mutation_p.A521G	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	679					response to DNA damage stimulus	nucleus	zinc ion binding				0						TTCTTACTCGCAGATACCTCT	0.443													0	0	0	0.173368	0	33	141										G	81078139	C	G	81078139	3	3	58	1	0	0	0	0	1	0	0	0	1110	710	25	4	2050	4	ATMIN	16	81078139	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	52200443	81078139	9276614	87	16774										
OR3A1	4994	broad.mit.edu	37	chr17	3195282	3195282	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cacagcaaaaagcagcagctCattgagttgggtgctggagc	13	9	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:3195282C>T	uc002fvh.1	-	1	595	c.595G>A	c.(595-597)GAG>AAG	p.E199K		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						AGCAGCAGCTCATTGAGTTGG	0.522													0	0	0	0.021553	0	5	94										T	3195282	C	T	3195282	3	4	58	1	0	0	0	0	1	0	0	0	11037	835	29	1	356	1	OR3A1	17	3195282	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		3195282	77999928	88	16775										
C17orf74	201243	broad.mit.edu	37	chr17	7329763	7329763	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccgcagaactacagacaaatCccccatagccactcagtctt	5	16	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:7329763C>T	uc002ggw.2	+	3	526	c.453C>T	c.(451-453)ATC>ATT	p.I151I	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	151						integral to membrane					0		Prostate(122;0.157)				ACAGACAAATCCCCCATAGCC	0.413													0	0	0	0.074837	0	36	27										T	7329763	C	T	7329763	2	4	58	1	0	0	0	0	0	0	0	1	1879	845	30	1		1	C17orf74	17	7329763	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	4134481	7329763	73865447	89	16776										
TP53	7157	broad.mit.edu	37	chr17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cccaggacaggcacaaacacGcacctcaaagctgttccgtc	8	16	1	0	rs121913343		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.043863	0	19	3										A	7577121	G	A	7577121	3	1	58	1	0	0	0	0	1	0	0	0	16378	1087	38	2	469	2	TP53	17	7577121	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	247358	7577121	73618089	90	16777										
CRLF3	51379	broad.mit.edu	37	chr17	29112973	29112973	+	Frame_Shift_Del	DEL	G	G	-													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cacagcttgatcccgctgcaGagagtcatatccatcctgtt							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:29112973delG	uc002hfr.3	-	7	1145	c.1036delC	c.(1036-1038)CTGfs	p.L346fs	CRLF3_uc010wbr.1_Frame_Shift_Del_p.L230fs	NM_015986	NP_057070	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	346					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm					0		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TCCCGCTGCAGAGAGTCATAT	0.368																		31	283	---	---								-	29112973	G	-	29112973	7	5	58	1	0	1	0	1	0	0	0	0	3888	933	33	0	300	0	CRLF3	17	29112973	Frame_Shift_Del	DEL	G	TCGA-DK-A3IM-01A-11D-A20D-08	21535852	29112973	52082237	91	16778										
ATP6V0A1	535	broad.mit.edu	37	chr17	40660605	40660605	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tcaagccttccgaggacgaaGtggtaagatgaaagctggcg	14	8	1	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:40660605G>A	uc002hzr.2	+	19	2295	c.2128G>A	c.(2128-2130)GTG>ATG	p.V710M	ATP6V0A1_uc002hzq.2_Intron|ATP6V0A1_uc002hzs.2_Intron|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.V667M|ATP6V0A1_uc010wgk.1_Intron|ATP6V0A1_uc010cyg.2_Missense_Mutation_p.V356M|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.V569M|ATP6V0A1_uc002hzt.2_Intron	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	710	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CGAGGACGAAGTGGTAAGATG	0.517													0	0	0	0.139131	0	47	44										A	40660605	G	A	40660605	3	1	58	1	0	0	0	0	1	0	0	0	1168	1029	36	2	2219	2	ATP6V0A1	17	40660605	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	11547632	40660605	40534605	92	16779										
AOC3	8639	broad.mit.edu	37	chr17	41008400	41008400	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gcttcttcctccgaccctatAacttctttgacgaagacccc	5	16	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:41008400A>C	uc002ibv.2	+	4	2285	c.2125A>C	c.(2125-2127)AAC>CAC	p.N709H		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	709	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CCGACCCTATAACTTCTTTGA	0.572													0	0	0	0.09319	0	10	76										C	41008400	A	C	41008400	3	2	58	1	0	0	0	0	1	0	0	0	728	362	13	5	2139	5	AOC3	17	41008400	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	347795	41008400	40186810	93	16780										
ZNF652	22834	broad.mit.edu	37	chr17	47388796	47388796	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gggagcgtagctggtacttgTactgaaacctttcgtcacag	12	9	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:47388796T>C	uc002iov.3	-	5	1651	c.1187A>G	c.(1186-1188)TAC>TGC	p.Y396C	ZNF652_uc002iow.2_Missense_Mutation_p.Y396C|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	396	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CTGGTACTTGTACTGAAACCT	0.458													0	0	0	0.139131	0	106	160										C	47388796	T	C	47388796	3	2	58	1	0	0	0	0	1	0	0	0	18062	1638	57	5	641	5	ZNF652	17	47388796	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	6380396	47388796	33806414	94	16781										
NXPH3	11248	broad.mit.edu	37	chr17	47656111	47656111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccactctcctagggctgctgGccccgcctggggaggcttgg	15	15	1	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:47656111G>A	uc002ipa.2	+	2	492	c.208G>A	c.(208-210)GCC>ACC	p.A70T	NXPH3_uc010wlw.1_Missense_Mutation_p.A70T	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	70	II.				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					AGGGCTGCTGGCCCCGCCTGG	0.682													0	0	0	0.131918	0	40	48										A	47656111	G	A	47656111	3	1	58	1	0	0	0	0	1	0	0	0	10792	1203	42	2	214	2	NXPH3	17	47656111	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	267315	47656111	33539099	95	16782										
GPR142	350383	broad.mit.edu	37	chr17	72363883	72363883	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	caaggactccagcagtttccGccaggtgaatccagctgcct	10	14	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr17:72363883G>A	uc010wqy.1	+	1	239	c.239G>A	c.(238-240)CGC>CAC	p.R80H	GPR142_uc010wqx.1_5'UTR	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	80	Extracellular (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						AGCAGTTTCCGCCAGGTGAAT	0.562													0	0	0	0.125774	0	26	28										A	72363883	G	A	72363883	3	1	58	1	0	0	0	0	1	0	0	0	6650	1087	38	2	241	2	GPR142	17	72363883	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	24707772	72363883	8831327	96	16783										
TCF4	6925	broad.mit.edu	37	chr18	53254339	53254339	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	aaggcagccattcgctgttgGtgatgcattttagcaaaatc	10	8	0	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr18:53254339G>A	uc002lfz.2	-	2	621	c.9C>T	c.(7-9)CAC>CAT	p.H3H	TCF4_uc010xdx.1_5'Flank|TCF4_uc010dph.1_Silent_p.H3H|TCF4_uc010xdy.1_Intron|TCF4_uc002lga.2_Silent_p.H105H|TCF4_uc010dpi.2_Silent_p.H3H	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	3	Essential for MYOD1 inhibition (By similarity).				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TTCGCTGTTGGTGATGCATTT	0.423													0	0	0	0.131918	0	37	14										A	53254339	G	A	53254339	2	1	58	1	0	0	0	0	0	0	0	1	15692	1252	44	2		2	TCF4	18	53254339	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		53254339	24822909	97	16784										
TMPRSS9	360200	broad.mit.edu	37	chr19	2403105	2403105	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tgtccagggaactccttttcCtgcgggaacagccagtgtgt	12	11	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:2403105C>T	uc010xgx.1	+	5	480	c.480C>T	c.(478-480)TCC>TCT	p.S160S	TMPRSS9_uc002lvv.1_Silent_p.S194S	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	160	LDL-receptor class A.|Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCCTTTTCCTGCGGGAACA	0.572													0	0	0	0.160694	0	12	8										T	2403105	C	T	2403105	2	4	58	1	0	0	0	0	0	0	0	1	16250	668	24	2		2	TMPRSS9	19	2403105	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		2403105	56725878	98	16785										
DIRAS1	148252	broad.mit.edu	37	chr19	2717599	2717599	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tggacaggcgctgcatggccGggaactggtggctgccggtg	19	10	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:2717599G>A	uc002lwf.3	-	2	364	c.206C>T	c.(205-207)CCG>CTG	p.P69L		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	69					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCATGGCCGGGAACTGGTG	0.622													0	0	0	0.115264	0	3	38										A	2717599	G	A	2717599	3	1	58	1	0	0	0	0	1	0	0	0	4530	1116	39	2	394	2	DIRAS1	19	2717599	Missense_Mutation	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	314494	2717599	56411384	99	16786										
MUC16	94025	broad.mit.edu	37	chr19	9061676	9061676	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ccaagggtgagaagtgcagtCacaggatgaggagaggagga	18	5	1	3			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:9061676C>T	uc002mkp.2	-	3	25974	c.25770G>A	c.(25768-25770)GTG>GTA	p.V8590V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8592	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGTGCAGTCACAGGATGAG	0.507													0	0	0	0.099896	0	26	15										T	9061676	C	T	9061676	2	4	58	1	0	0	0	0	0	0	0	1	9973	813	29	1		1	MUC16	19	9061676	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	6344077	9061676	50067307	100	16787										
CNN1	1264	broad.mit.edu	37	chr19	11660528	11660528	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	acgccaggtctacgaccccaAgtactgtctgactcccgagt	9	15	2	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:11660528A>C	uc002msc.1	+	7	976	c.812A>C	c.(811-813)AAG>ACG	p.K271T	CNN1_uc010xmb.1_Missense_Mutation_p.K221T|CNN1_uc010xmc.1_Missense_Mutation_p.K221T	NM_001299	NP_001290	P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	271					actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding				0						TACGACCCCAAGTACTGTCTG	0.622													0	0	0	0.132662	0	13	73										C	11660528	A	C	11660528	3	2	58	1	0	0	0	0	1	0	0	0	3609	72	3	5	838	5	CNN1	19	11660528	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	2598852	11660528	47468455	101	16788										
ZNF208	7757	broad.mit.edu	37	chr19	22155320	22155320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agaacttactaaaggctttgCcacattctttacatttgtag	6	8	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:22155320C>T	uc002nqp.2	-	5	2365	c.2216G>A	c.(2215-2217)GGC>GAC	p.G739D	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAAGGCTTTGCCACATTCTTT	0.373													0	0	0	0.160694	0	17	67										T	22155320	C	T	22155320	3	4	58	1	0	0	0	0	1	0	0	0	17763	739	26	2	1330	2	ZNF208	19	22155320	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	10494792	22155320	36973663	102	16789										
KIAA0355	9710	broad.mit.edu	37	chr19	34810899	34810899	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	aggtccagccggtggctcacTcttgctttgctgaggtcatc	12	12	3	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:34810899T>C	uc002nvd.3	+	3	1442	c.583T>C	c.(583-585)TCT>CCT	p.S195P		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	195										ovary(1)	1	Esophageal squamous(110;0.162)					GGTGGCTCACTCTTGCTTTGC	0.532													0	0	0	0.150653	0	3	140										C	34810899	T	C	34810899	3	2	58	1	0	0	0	0	1	0	0	0	8170	1551	54	5	589	5	KIAA0355	19	34810899	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	12655579	34810899	24318084	103	16790										
CYP2A13	1553	broad.mit.edu	37	chr19	41594393	41594393	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	caccatgctggcctcagggcTgcttctggtgaccttgctgg	13	13	2	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:41594393T>G	uc002opt.2	+	1	26	c.17T>G	c.(16-18)CTG>CGG	p.L6R		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	6					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GCCTCAGGGCTGCTTCTGGTG	0.572													0	0	0	0.11911	0	11	32										G	41594393	T	G	41594393	3	3	58	1	0	0	0	0	1	0	0	0	4161	1580	55	5	19	5	CYP2A13	19	41594393	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	6783494	41594393	17534590	104	16791										
CADM4	199731	broad.mit.edu	37	chr19	44129330	44129330	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gataccagacccggcagcgtGagcgtctctcccacggcctc	11	17	1	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr19:44129330G>A	uc002oxc.1	-	7	877	c.828C>T	c.(826-828)CTC>CTT	p.L276L		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	276	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				CCGGCAGCGTGAGCGTCTCTC	0.607													0	0	0	0.0918	0	24	22										A	44129330	G	A	44129330	2	1	58	1	0	0	0	0	0	0	0	1	2569	1277	45	1		1	CADM4	19	44129330	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	2534937	44129330	14999653	105	16792										
NCOA6	23054	broad.mit.edu	37	chr20	33329786	33329786	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tctgggaattctggcaatcaCtgtcctgaggcacattcaag	10	10	4	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr20:33329786C>A	uc002xav.2	-	12	6845	c.4274G>T	c.(4273-4275)AGT>ATT	p.S1425I	NCOA6_uc002xaw.2_Missense_Mutation_p.S1425I	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1425					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTGGCAATCACTGTCCTGAGG	0.468													1	0	4.7546e-09	0.146539	5.30021e-09	15	96										A	33329786	C	A	33329786	3	1	58	1	0	0	0	0	1	0	0	0	10233	565	20	4	1937	4	NCOA6	20	33329786	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08		33329786	29695734	106	16793										
RBL1	5933	broad.mit.edu	37	chr20	35724278	35724278	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cacagggcctgtagcgcctcCccggctgcggcgaccaccgc	13	19	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr20:35724278C>A	uc002xgi.2	-	1	133	c.54G>T	c.(52-54)GGG>GGT	p.G18G	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.G18G|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	18					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				GTAGCGCCTCCCCGGCTGCGG	0.697													1	0	3.09899e-07	0.047766	3.34494e-07	5	4										A	35724278	C	A	35724278	2	1	58	1	0	0	0	0	0	0	0	1	13109	610	22	4		4	RBL1	20	35724278	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2394492	35724278	27301242	107	16794										
ZNF831	128611	broad.mit.edu	37	chr20	57767397	57767397	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	tccaaacagggcagcatcgaCctgcccacgccctacaccta	7	18	0	0			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr20:57767397C>T	uc002yan.2	+	1	1323	c.1323C>T	c.(1321-1323)GAC>GAT	p.D441D		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	441						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCAGCATCGACCTGCCCACGC	0.677													0	0	0	0.021553	0	5	23										T	57767397	C	T	57767397	2	4	58	1	0	0	0	0	0	0	0	1	18182	506	18	2		2	ZNF831	20	57767397	Silent	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	22043119	57767397	5258123	108	16795										
USP25	29761	broad.mit.edu	37	chr21	17250653	17250653	+	Frame_Shift_Del	DEL	G	G	-													0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gaaaagctgacagattttttGccaaaactgcttgattgttc							TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chr21:17250653delG	uc002yjy.1	+	24	3244	c.3027delG	c.(3025-3027)TTGfs	p.L1009fs	USP25_uc011aby.1_Frame_Shift_Del_p.L1079fs|USP25_uc002yjz.1_Frame_Shift_Del_p.L1041fs|USP25_uc010gla.1_Frame_Shift_Del_p.L404fs	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	1009					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		CAGATTTTTTGCCAAAACTGC	0.363																		57	47	---	---								-	17250653	G	-	17250653	7	5	58	1	0	1	0	1	0	0	0	0	17053	1310	46	0	3121	0	USP25	21	17250653	Frame_Shift_Del	DEL	G	TCGA-DK-A3IM-01A-11D-A20D-08		17250653	30879242	109	16796										
PNPLA4	8228	broad.mit.edu	37	chrX	7870171	7870171	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agagcgttggtgaggcctccGtccacccacttctgtggaaa	12	12	1	2	rs150755827		TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:7870171G>A	uc011mhq.1	-	6	651	c.489C>T	c.(487-489)GAC>GAT	p.D163D	PNPLA4_uc011mhr.1_Silent_p.D163D|PNPLA4_uc011mhs.1_Silent_p.D76D	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	163	Patatin.				lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				TGAGGCCTCCGTCCACCCACT	0.542													0	0	0	0.116897	0	26	4										A	7870171	G	A	7870171	2	1	58	1	0	0	0	0	0	0	0	1	12167	1136	40	2		2	PNPLA4	23	7870171	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08		7870171	147400389	110	16797										
ZFX	7543	broad.mit.edu	37	chrX	24225885	24225885	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	atgatcatggagttgaactgCttgatcagaacagcagtatt	10	6	2	4			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:24225885C>A	uc004dbf.2	+	6	1111	c.853C>A	c.(853-855)CTT>ATT	p.L285I	ZFX_uc004dbd.1_Missense_Mutation_p.L285I|ZFX_uc010nfx.1_Missense_Mutation_p.L56I|ZFX_uc004dbe.2_Missense_Mutation_p.L285I|ZFX_uc011mjv.1_Missense_Mutation_p.L324I|ZFX_uc010nfy.1_Intron|ZFX_uc010nfz.2_5'UTR	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						AGTTGAACTGCTTGATCAGAA	0.403													1	0	7.03913e-09	0.09319	7.7831e-09	11	122										A	24225885	C	A	24225885	3	1	58	1	0	0	0	0	1	0	0	0	17658	797	28	4	867	4	ZFX	23	24225885	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	16355714	24225885	131044675	111	16798										
FAM47C	442444	broad.mit.edu	37	chrX	37027200	37027200	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	agtctccacctggagcctccAgagactggagtgtcccatct	10	14	2	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637													0	0	0	0.115264	0	3	53										C	37027200	A	C	37027200	2	2	58	1	0	0	0	0	0	0	0	1	5571	175	7	5		5	FAM47C	23	37027200	Silent	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	12801315	37027200	118243360	112	16799										
FAM47C	442444	broad.mit.edu	37	chrX	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	gtctccgcccggagcctcccAatactggagtgtcccatctc	9	17	2	0	rs145580328	byFrequency	TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:37028425A>G	uc004ddl.1	+	1	1956	c.1942A>G	c.(1942-1944)AAT>GAT	p.N648D		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	648										ovary(3)	3						GGAGCCTCCCAATACTGGAGT	0.642													0	0	0	0.014758	0	4	78										G	37028425	A	G	37028425	3	3	58	1	0	0	0	0	1	0	0	0	5571	130	5	5	1944	5	FAM47C	23	37028425	Missense_Mutation	SNP	A	TCGA-DK-A3IM-01A-11D-A20D-08	1225	37028425	118242135	113	16800										
ZCCHC5	203430	broad.mit.edu	37	chrX	77912689	77912689	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ctggtggactctcgggtccaTctccctctgcagaggaactt	11	13	3	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:77912689T>A	uc004edc.1	-	2	1525	c.1229A>T	c.(1228-1230)GAT>GTT	p.D410V		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	410							nucleic acid binding|zinc ion binding			ovary(1)	1						CTCGGGTCCATCTCCCTCTGC	0.537													0	0	0	0.139131	0	53	9										A	77912689	T	A	77912689	3	1	58	1	0	0	0	0	1	0	0	0	17588	1435	50	5	202	5	ZCCHC5	23	77912689	Missense_Mutation	SNP	T	TCGA-DK-A3IM-01A-11D-A20D-08	40884264	77912689	77357871	114	16801										
NXF3	56000	broad.mit.edu	37	chrX	102334726	102334726	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	ggattgaagggaatgctcagGgagaagcaggcctcatcgtg	16	7	2	2			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:102334726G>A	uc004eju.2	-	13	1196	c.1125C>T	c.(1123-1125)TCC>TCT	p.S375S	NXF3_uc010noi.1_Silent_p.S225S	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	375	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GAATGCTCAGGGAGAAGCAGG	0.547													0	0	0	0.115264	0	3	70										A	102334726	G	A	102334726	2	1	58	1	0	0	0	0	0	0	0	1	10785	1219	43	2		2	NXF3	23	102334726	Silent	SNP	G	TCGA-DK-A3IM-01A-11D-A20D-08	24422037	102334726	52935834	115	16802										
TEX13A	56157	broad.mit.edu	37	chrX	104463696	104463696	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0517241379310345	6	0.873117481421949	0.704989786985702	0.737034777303234	0.698912288822032	0.131221719457014	0.258467023172906	0	cccacagtcgaagcaagtatCcctccgtgaaaaattcacag	7	13	1	1			TCGA-DK-A3IM-01A-11D-A20D-08	TCGA-DK-A3IM-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	780f4201-4e59-47b8-b3b7-d322a6162b2d	fdf4684d-6346-469c-b07b-5d4846a8816a	g.chrX:104463696C>A	uc004ema.2	-	5	1292	c.1180G>T	c.(1180-1182)GAT>TAT	p.D394Y	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_3'UTR	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	394	RanBP2-type.					intracellular	zinc ion binding			ovary(2)	2						AAGCAAGTATCCCTCCGTGAA	0.488													1	0	3.6533e-62	0.139131	4.32043e-62	121	19										A	104463696	C	A	104463696	3	1	58	1	0	0	0	0	1	0	0	0	15773	842	30	3	53	3	TEX13A	23	104463696	Missense_Mutation	SNP	C	TCGA-DK-A3IM-01A-11D-A20D-08	2128970	104463696	50806864	116	16803										
ATAD3B	83858	broad.mit.edu	37	chr1	1417558	1417558	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gagctgcggcacaagaatgaGatgctgcgagtggagaccga	16	8	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:1417558G>A	uc001afv.2	+	6	656	c.555G>A	c.(553-555)GAG>GAA	p.E185E	ATAD3B_uc001afw.2_Silent_p.E139E|ATAD3B_uc001afx.2_Silent_p.E139E	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	185	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		ACAAGAATGAGATGCTGCGAG	0.672													0	0	0	0.009096	0	4	23										A	1417558	G	A	1417558	2	1	59	1	0	0	0	0	0	0	0	1	1074	933	33	1		1	ATAD3B	1	1417558	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		1417558	247833063	1	16804										
PLCH2	9651	broad.mit.edu	37	chr1	2420790	2420790	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accacactcccctctccacaGatgctcaagggcaagatcct	6	17	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:2420790G>T	uc001aji.1	+	9	1654	c.1380G>T	c.(1378-1380)CAG>CAT	p.Q460H	PLCH2_uc010nyz.1_Missense_Mutation_p.Q248H|PLCH2_uc009vle.1_Missense_Mutation_p.Q248H|PLCH2_uc001ajj.1_Missense_Mutation_p.Q248H|PLCH2_uc001ajk.1_Missense_Mutation_p.Q248H	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	460	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CCTCTCCACAGATGCTCAAGG	0.582													1	0	2.80697e-09	0.010729	2.96018e-09	11	65										T	2420790	G	T	2420790	3	4	59	1	0	0	0	0	1	0	0	0	12038	933	33	3	1414	3	PLCH2	1	2420790	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1003232	2420790	246829831	2	16805										
PRDM16	63976	broad.mit.edu	37	chr1	3331170	3331170	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accccgtgggagccctgaagGagaagtacctgcggccgtcc	14	14	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:3331170G>C	uc001akf.2	+	10	2730	c.2650G>C	c.(2650-2652)GAG>CAG	p.E884Q	PRDM16_uc001akc.2_Missense_Mutation_p.E883Q|PRDM16_uc001akd.2_Missense_Mutation_p.E883Q|PRDM16_uc001ake.2_Missense_Mutation_p.E884Q|PRDM16_uc009vlh.2_Missense_Mutation_p.E584Q	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	884	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCCCTGAAGGAGAAGTACCT	0.667			T	EVI1	MDS|AML								0	0	0	0.014758	0	4	27										C	3331170	G	C	3331170	3	2	59	1	0	0	0	0	1	0	0	0	12457	1175	41	1	2688	1	PRDM16	1	3331170	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	910380	3331170	245919451	3	16806										
PIK3CD	5293	broad.mit.edu	37	chr1	9775796	9775796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaccgcgtgaagaagctcatCaactcacagatcagcctcct	8	14	4	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:9775796C>G	uc001aqb.3	+	4	547	c.339C>G	c.(337-339)ATC>ATG	p.I113M	PIK3CD_uc001aqa.2_Missense_Mutation_p.I113M|PIK3CD_uc010oaf.1_Missense_Mutation_p.I113M|PIK3CD_uc001aqe.3_Missense_Mutation_p.I113M	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	113					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		AGAAGCTCATCAACTCACAGA	0.677													0	0	0	0.014323	0	17	54										G	9775796	C	G	9775796	3	3	59	1	0	0	0	0	1	0	0	0	11915	816	29	1	345	1	PIK3CD	1	9775796	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6444626	9775796	239474825	4	16807										
C1orf127	148345	broad.mit.edu	37	chr1	11008902	11008902	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aggaatggtccaagccccttCttcaccaagagagaagtgga	11	10	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:11008902C>T	uc010oao.1	-	8	849	c.844_splice	c.e8-1	p.K282_splice	C1orf127_uc001arr.1_Splice_Site_p.K264_splice|C1orf127_uc001ars.1_Splice_Site_p.K256_splice	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345											ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CAAGCCCCTTCTTCACCAAGA	0.537													0	0	0	0.003163	0	14	34										T	11008902	C	T	11008902	5	4	59	1	0	0	0	0	0	0	1	0	1994	927	32	1	1185	1	C1orf127	1	11008902	Splice_Site	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1233106	11008902	238241719	5	16808										
PRDM2	7799	broad.mit.edu	37	chr1	14104976	14104976	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcagccggccaccctccaggAggtggccagtcaggaggtgc	16	14	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:14104976A>T	uc001avi.2	+	8	1542	c.686A>T	c.(685-687)GAG>GTG	p.E229V	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.E229V|PRDM2_uc001avj.2_Intron|PRDM2_uc009vod.1_Missense_Mutation_p.E28V|PRDM2_uc001avk.2_Missense_Mutation_p.E28V|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	229						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		ACCCTCCAGGAGGTGGCCAGT	0.582													0	0	0	0.001855	0	13	100										T	14104976	A	T	14104976	3	4	59	1	0	0	0	0	1	0	0	0	12458	304	11	5	712	5	PRDM2	1	14104976	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	3096074	14104976	235145645	6	16809										
PADI3	51702	broad.mit.edu	37	chr1	17586130	17586130	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggacgcctggcgtggacatCtacatctctcccaacatgga	11	13	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:17586130C>T	uc001bai.2	+	2	190	c.150C>T	c.(148-150)ATC>ATT	p.I50I		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	50					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCGTGGACATCTACATCTCTC	0.592													0	0	0	0.010504	0	17	72										T	17586130	C	T	17586130	2	4	59	1	0	0	0	0	0	0	0	1	11379	903	32	1		1	PADI3	1	17586130	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3481154	17586130	231664491	7	16810										
PADI3	51702	broad.mit.edu	37	chr1	17592186	17592186	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	attgcgacctgaactgtgagGgaaggcaggacaggaacttt	14	7	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:17592186G>A	uc001bai.2	+	4	419	c.379G>A	c.(379-381)GGA>AGA	p.G127R		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	127					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GAACTGTGAGGGAAGGCAGGA	0.547													0	0	0	0.00245	0	11	120										A	17592186	G	A	17592186	3	1	59	1	0	0	0	0	1	0	0	0	11379	1233	43	2	393	2	PADI3	1	17592186	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6056	17592186	231658435	8	16811										
KIF17	57576	broad.mit.edu	37	chr1	21014070	21014070	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcaggtgcccagcggcctcCtgcccgaggcactcatccag	12	17	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:21014070C>G	uc001bdr.3	-	8	1867	c.1749G>C	c.(1747-1749)CAG>CAC	p.Q583H	KIF17_uc001bdp.3_5'Flank|KIF17_uc001bdq.3_5'Flank|KIF17_uc009vpx.2_Intron|KIF17_uc001bds.3_Missense_Mutation_p.Q583H	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	583					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CAGCGGCCTCCTGCCCGAGGC	0.652													0	0	0	0.004482	0	6	19										G	21014070	C	G	21014070	3	3	59	1	0	0	0	0	1	0	0	0	8279	680	24	4	1372	4	KIF17	1	21014070	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3421884	21014070	228236551	9	16812										
EPHB2	2048	broad.mit.edu	37	chr1	23107946	23107946	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actccactacagcgactgctGagctgggctggatggtgcat	13	11	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:23107946G>A	uc009vqj.1	+	2	239	c.94G>A	c.(94-96)GAG>AAG	p.E32K	EPHB2_uc001bge.2_Missense_Mutation_p.E32K|EPHB2_uc001bgf.2_Missense_Mutation_p.E32K|EPHB2_uc010odu.1_Missense_Mutation_p.E32K	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	32	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AGCGACTGCTGAGCTGGGCTG	0.602									Hereditary_Prostate_Cancer				0	0	0	0.008361	0	24	44										A	23107946	G	A	23107946	3	1	59	1	0	0	0	0	1	0	0	0	5175	1291	45	1	100	1	EPHB2	1	23107946	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2093876	23107946	226142675	10	16813										
RPL11	6135	broad.mit.edu	37	chr1	24019138	24019138	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agaaccccatgcgggaacttCgcatccgcaaactctgtctc	8	15	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:24019138C>T	uc001bhk.2	+	2	66	c.46C>T	c.(46-48)CGC>TGC	p.R16C	RPL11_uc001bhl.2_Missense_Mutation_p.R15C|RPL11_uc001bhm.2_Missense_Mutation_p.R5C|RPL11_uc001bhn.1_Missense_Mutation_p.R5C	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	16					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		GCGGGAACTTCGCATCCGCAA	0.547													0	0	0	0.01441	0	52	125										T	24019138	C	T	24019138	3	4	59	1	0	0	0	0	1	0	0	0	13557	884	31	1	52	1	RPL11	1	24019138	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	911192	24019138	225231483	11	16814										
GRHL3	57822	broad.mit.edu	37	chr1	24673086	24673086	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgcccttcactgaggagtttGagcctctgccctccaagcag	10	15	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:24673086G>C	uc001biy.2	+	13	1559	c.1513G>C	c.(1513-1515)GAG>CAG	p.E505Q	GRHL3_uc001bix.2_Missense_Mutation_p.E500Q|GRHL3_uc001biz.2_Missense_Mutation_p.E407Q	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	500					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TGAGGAGTTTGAGCCTCTGCC	0.622													0	0	0	0.013537	0	11	35										C	24673086	G	C	24673086	3	2	59	1	0	0	0	0	1	0	0	0	6765	1291	45	1	1584	1	GRHL3	1	24673086	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	653948	24673086	224577535	12	16815										
ARID1A	8289	broad.mit.edu	37	chr1	27094291	27094291	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaccttccagaaatccagttCttctactacaaccaatgaga	4	12	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:27094291C>T	uc001bmv.1	+	11	3372	c.2999C>T	c.(2998-3000)TCT>TTT	p.S1000F	ARID1A_uc001bmt.1_Missense_Mutation_p.S1000F|ARID1A_uc001bmu.1_Missense_Mutation_p.S1000F|ARID1A_uc001bmw.1_Missense_Mutation_p.S617F	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1000	Poly-Ser.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AAATCCAGTTCTTCTACTACA	0.473			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.010729	0	11	26										T	27094291	C	T	27094291	3	4	59	1	0	0	0	0	1	0	0	0	913	913	32	1	3041	1	ARID1A	1	27094291	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2421205	27094291	222156330	13	16816										
ARID1A	8289	broad.mit.edu	37	chr1	27100195	27100195	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accccccgcagcagcagcagCagcagcagcaacggtgagta	12	15	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:27100195C>T	uc001bmv.1	+	16	4364	c.3991C>T	c.(3991-3993)CAG>TAG	p.Q1331*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1330*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1331*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q948*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q177*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1331	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		gcagcagcagcagcagcagca	0.502			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.005524	0	38	87										T	27100195	C	T	27100195	4	4	59	1	0	0	0	0	0	1	0	0	913	711	25	2	4053	2	ARID1A	1	27100195	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5904	27100195	222150426	14	16817										
FAM46B	115572	broad.mit.edu	37	chr1	27332971	27332971	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaagtccccgtacaggctttCgcctgtgaccgttgggtgga	14	11	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:27332971C>T	uc010ofj.1	-	2	914	c.742G>A	c.(742-744)GAA>AAA	p.E248K		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	248										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		TACAGGCTTTCGCCTGTGACC	0.622													0	0	0	0.008291	0	9	19										T	27332971	C	T	27332971	3	4	59	1	0	0	0	0	1	0	0	0	5566	893	31	1	539	1	FAM46B	1	27332971	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	232776	27332971	221917650	15	16818										
EPB41	2035	broad.mit.edu	37	chr1	29319848	29319848	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcatggatatgtagcctgctCaggaagaactcagagaagat	11	7	3	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:29319848C>G	uc001brm.1	+	2	482	c.475C>G	c.(475-477)CAG>GAG	p.Q159E	EPB41_uc001brg.1_5'UTR|EPB41_uc001brh.1_5'UTR|EPB41_uc001bri.1_Missense_Mutation_p.Q159E|EPB41_uc001brj.1_5'UTR|EPB41_uc009vtk.1_Missense_Mutation_p.Q159E|EPB41_uc001brk.2_Missense_Mutation_p.Q159E|EPB41_uc001brl.1_Missense_Mutation_p.Q159E|EPB41_uc009vtl.1_5'UTR|EPB41_uc009vtm.1_Intron	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	159					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GTAGCCTGCTCAGGAAGAACT	0.358													0	0	0	0.01441	0	53	133										G	29319848	C	G	29319848	3	3	59	1	0	0	0	0	1	0	0	0	5151	827	29	1	481	1	EPB41	1	29319848	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1986877	29319848	219930773	16	16819										
EPB41	2035	broad.mit.edu	37	chr1	29319941	29319941	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aagtaaaagaagaaagccctCaatcaaaagcagaaacagaa	7	7	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:29319941C>G	uc001brm.1	+	2	575	c.568C>G	c.(568-570)CAA>GAA	p.Q190E	EPB41_uc001brg.1_5'UTR|EPB41_uc001brh.1_5'UTR|EPB41_uc001bri.1_Missense_Mutation_p.Q190E|EPB41_uc001brj.1_5'UTR|EPB41_uc009vtk.1_Missense_Mutation_p.Q190E|EPB41_uc001brk.2_Missense_Mutation_p.Q190E|EPB41_uc001brl.1_Missense_Mutation_p.Q190E|EPB41_uc009vtl.1_5'UTR|EPB41_uc009vtm.1_Intron	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	190					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		AGAAAGCCCTCAATCAAAAGC	0.388													0	0	0	0.00632	0	26	62										G	29319941	C	G	29319941	3	3	59	1	0	0	0	0	1	0	0	0	5151	827	29	1	574	1	EPB41	1	29319941	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	93	29319941	219930680	17	16820										
S100PBP	64766	broad.mit.edu	37	chr1	33291827	33291827	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actccttgctggagctgtcaGagggagaagaagatgatggt	15	6	1	5			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33291827G>A	uc001bvz.2	+	3	404	c.127G>A	c.(127-129)GAG>AAG	p.E43K	S100PBP_uc001bwa.1_Missense_Mutation_p.E43K|S100PBP_uc001bwb.1_Missense_Mutation_p.E43K|S100PBP_uc001bwc.2_Missense_Mutation_p.E43K|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	43						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GGAGCTGTCAGAGGGAGAAGA	0.468													0	0	0	0.004878	0	35	136										A	33291827	G	A	33291827	3	1	59	1	0	0	0	0	1	0	0	0	13791	943	33	1	129	1	S100PBP	1	33291827	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3971886	33291827	215958794	18	16821			1	65		4	4	414	G		3.932094e-08
S100PBP	64766	broad.mit.edu	37	chr1	33292181	33292181	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagtttgtgatgctctgcttGataaggacgagactgattcg	12	7	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33292181G>C	uc001bvz.2	+	3	758	c.481G>C	c.(481-483)GAT>CAT	p.D161H	S100PBP_uc001bwa.1_Missense_Mutation_p.D161H|S100PBP_uc001bwb.1_Missense_Mutation_p.D161H|S100PBP_uc001bwc.2_Missense_Mutation_p.D161H|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	161						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TGCTCTGCTTGATAAGGACGA	0.383													0	0	0	0.007413	0	11	51										C	33292181	G	C	33292181	3	2	59	1	0	0	0	0	1	0	0	0	13791	1290	45	1	483	1	S100PBP	1	33292181	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	354	33292181	215958440	19	16822			1	65		4	4	414	G		3.932094e-08
S100PBP	64766	broad.mit.edu	37	chr1	33292214	33292214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctgattcgtccaaagatactGaaaaactctcttcccttgga	6	11	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33292214G>A	uc001bvz.2	+	3	791	c.514G>A	c.(514-516)GAA>AAA	p.E172K	S100PBP_uc001bwa.1_Missense_Mutation_p.E172K|S100PBP_uc001bwb.1_Missense_Mutation_p.E172K|S100PBP_uc001bwc.2_Missense_Mutation_p.E172K|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	172						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CAAAGATACTGAAAAACTCTC	0.393													0	0	0	0.010504	0	12	46										A	33292214	G	A	33292214	3	1	59	1	0	0	0	0	1	0	0	0	13791	1291	45	1	516	1	S100PBP	1	33292214	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	33	33292214	215958407	20	16823			1	65		4	4	414	G		3.932094e-08
S100PBP	64766	broad.mit.edu	37	chr1	33292240	33292240	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctctcttcccttggagaagaGatgagagaagatggtcttag	12	7	2	5			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33292240G>A	uc001bvz.2	+	3	817	c.540G>A	c.(538-540)GAG>GAA	p.E180E	S100PBP_uc001bwa.1_Silent_p.E180E|S100PBP_uc001bwb.1_Silent_p.E180E|S100PBP_uc001bwc.2_Silent_p.E180E|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	180						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TTGGAGAAGAGATGAGAGAAG	0.448													0	0	0	0.014323	0	15	47										A	33292240	G	A	33292240	2	1	59	1	0	0	0	0	0	0	0	1	13791	933	33	1		1	S100PBP	1	33292240	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	26	33292240	215958381	21	16824			1	65		4	4	414	G		3.932094e-08
GJB3	2707	broad.mit.edu	37	chr1	35251005	35251005	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tacctcatctgccacagggtCctgcgaggcctgcacaagga	11	14	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:35251005C>G	uc001bxx.2	+	2	1257	c.642C>G	c.(640-642)GTC>GTG	p.V214V	GJB3_uc001bxy.2_Silent_p.V214V|GJB3_uc001bxz.3_Silent_p.V214V|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	214	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GCCACAGGGTCCTGCGAGGCC	0.622													0	0	0	0.00245	0	13	33										G	35251005	C	G	35251005	2	3	59	1	0	0	0	0	0	0	0	1	6409	842	30	1		1	GJB3	1	35251005	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1958765	35251005	213999616	22	16825										
GRIK3	2899	broad.mit.edu	37	chr1	37319267	37319267	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atgtccagatcaaaatccgtCcgcaagccactagttttgtt	7	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:37319267C>T	uc001caz.2	-	8	1296	c.1161G>A	c.(1159-1161)CGG>CGA	p.R387R	GRIK3_uc001cba.1_Silent_p.R387R	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	387	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CAAAATCCGTCCGCAAGCCAC	0.547													0	0	0	0.016522	0	24	67										T	37319267	C	T	37319267	2	4	59	1	0	0	0	0	0	0	0	1	6775	842	30	1		1	GRIK3	1	37319267	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2068262	37319267	211931354	23	16826										
SLC2A1	6513	broad.mit.edu	37	chr1	43396370	43396370	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccccacgaagggctgtgggtGacacttcacccacatacatg	10	14	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:43396370G>A	uc001cik.2	-	4	968	c.443C>T	c.(442-444)TCA>TTA	p.S148L		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	148	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	GGCTGTGGGTGACACTTCACC	0.622													0	0	0	0.001168	0	6	16										A	43396370	G	A	43396370	3	1	59	1	0	0	0	0	1	0	0	0	14538	1294	45	1	1063	1	SLC2A1	1	43396370	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6077103	43396370	205854251	24	16827										
UROD	7389	broad.mit.edu	37	chr1	45479331	45479332	+	Frame_Shift_Del	DEL	AG	AG	-													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttcccagagccattaagagaAgagcaggacctagaacgcct							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:45479331_45479332delAG	uc001cna.1	+	5	450_451	c.342_343delAG	c.(340-345)GAAGAGfs	p.E114fs	HECTD3_uc009vxk.2_5'Flank|HECTD3_uc010olh.1_5'Flank|UROD_uc010oli.1_3'UTR|UROD_uc001cnb.1_Frame_Shift_Del_p.E79fs|UROD_uc010olj.1_Frame_Shift_Del_p.E58fs|UROD_uc001cnc.1_Frame_Shift_Del_p.E19fs	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	114_115						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					CATTAAGAGAAGAGCAGGACCT	0.559									Porphyria_Cutanea_Tarda_Type_II									13	56	---	---								-	45479332	AG	-	45479331	7	5	59	1	0	1	0	1	0	0	0	0	17026	69	3	0	360	0	UROD	1	45479331	Frame_Shift_Del	DEL	AG	TCGA-DK-A3IN-01A-11D-A20D-08	2082961	45479331	203771290	25	16828										
RAB3B	5865	broad.mit.edu	37	chr1	52442680	52442680	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagcatagcggaagaggaagGaggtcttgccaacactgctg	14	9	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:52442680G>T	uc001cth.2	-	2	235	c.110C>A	c.(109-111)TCC>TAC	p.S37Y		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	37	GTP.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						GAAGAGGAAGGAGGTCTTGCC	0.493													1	0	1.96895e-08	0.016522	2.06835e-08	22	90										T	52442680	G	T	52442680	3	4	59	1	0	0	0	0	1	0	0	0	12932	1174	41	3	565	3	RAB3B	1	52442680	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6963349	52442680	196807941	26	16829										
SCP2	6342	broad.mit.edu	37	chr1	53416446	53416446	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggtgactctacctgtgggcaGagggctatctatcacagttt	12	9	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:53416446G>C	uc001cur.1	+	4	340	c.219G>C	c.(217-219)CAG>CAC	p.Q73H	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_5'UTR|SCP2_uc010onp.1_Missense_Mutation_p.Q49H|SCP2_uc009vzi.1_Intron|SCP2_uc001cuq.1_Intron	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	73					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						CCTGTGGGCAGAGGGCTATCT	0.378													0	0	0	0.008361	0	28	66										C	53416446	G	C	53416446	3	2	59	1	0	0	0	0	1	0	0	0	13934	933	33	1	233	1	SCP2	1	53416446	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	973766	53416446	195834175	27	16830										
SSBP3	23648	broad.mit.edu	37	chr1	54692805	54692805	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgtctcggagaaggggggatCacacactcatcgtcatgctt	12	11	4	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:54692805C>T	uc001cxe.2	-	18	1464	c.1166G>A	c.(1165-1167)TGA>TAA	p.*389*	SSBP3_uc001cxf.2_Silent_p.*369*|SSBP3_uc001cxg.2_Silent_p.*362*|SSBP3_uc001cxd.2_Silent_p.*78*	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						AAGGGGGGATCACACACTCAT	0.567													0	0	0	0.01441	0	52	193										T	54692805	C	T	54692805	2	4	59	1	0	0	0	0	0	0	0	1	15180	837	29	1		1	SSBP3	1	54692805	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1276359	54692805	194557816	28	16831										
KANK4	163782	broad.mit.edu	37	chr1	62728783	62728783	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgtctccagcagcagcttCacgatggagaagttggagtg	13	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:62728783C>T	uc001dah.3	-	7	2897	c.2520G>A	c.(2518-2520)GTG>GTA	p.V840V	KANK4_uc001dai.3_Silent_p.V212V|KANK4_uc001daf.3_5'UTR|KANK4_uc001dag.3_Silent_p.V196V	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	840	ANK 1.									ovary(3)|skin(2)|lung(1)	6						GCAGCAGCTTCACGATGGAGA	0.473													0	0	0	0.008291	0	5	24										T	62728783	C	T	62728783	2	4	59	1	0	0	0	0	0	0	0	1	7979	813	29	1		1	KANK4	1	62728783	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	8035978	62728783	186521838	29	16832										
GBP1	2633	broad.mit.edu	37	chr1	89520378	89520378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tagatacctgaagtttaagaGcgagggtcctctcttgctct	10	9	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:89520378G>A	uc001dmx.2	-	10	1872	c.1652C>T	c.(1651-1653)GCT>GTT	p.A551V		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	551					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		AAGTTTAAGAGCGAGGGTCCT	0.448													0	0	0	0.00623	0	39	100										A	89520378	G	A	89520378	3	1	59	1	0	0	0	0	1	0	0	0	6273	971	34	2	134	2	GBP1	1	89520378	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	26791595	89520378	159730243	30	16833										
ZNF644	84146	broad.mit.edu	37	chr1	91405439	91405439	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actgtaatcgtgcacttcttCcttcatcctgaagttctttc	5	12	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:91405439C>T	uc001dnw.2	-	3	1614	c.1472G>A	c.(1471-1473)GGA>GAA	p.G491E	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.G491E	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TGCACTTCTTCCTTCATCCTG	0.388													0	0	0	0.010818	0	29	87										T	91405439	C	T	91405439	3	4	59	1	0	0	0	0	1	0	0	0	18057	855	30	1	2527	1	ZNF644	1	91405439	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1885061	91405439	157845182	31	16834										
ABCD3	5825	broad.mit.edu	37	chr1	94953293	94953293	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctagttgtcagtcgccctttCttagatttgtctcatcctcg	7	12	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:94953293C>G	uc001dqn.3	+	12	1113	c.1011C>G	c.(1009-1011)TTC>TTG	p.F337L	ABCD3_uc010oto.1_Missense_Mutation_p.F361L|ABCD3_uc010otp.1_Missense_Mutation_p.F264L|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.F25L	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	337	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GTCGCCCTTTCTTAGATTTGT	0.363													0	0	0	0.012213	0	18	85										G	94953293	C	G	94953293	3	3	59	1	0	0	0	0	1	0	0	0	62	912	32	1	1088	1	ABCD3	1	94953293	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3547854	94953293	154297328	32	16835			2	66	61661053	3	3	50	C		2.652146e-07
ABCD3	5825	broad.mit.edu	37	chr1	94953306	94953306	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccctttcttagatttgtctCatcctcgacatctcaagagt	6	12	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:94953306C>T	uc001dqn.3	+	12	1126	c.1024C>T	c.(1024-1026)CAT>TAT	p.H342Y	ABCD3_uc010oto.1_Missense_Mutation_p.H366Y|ABCD3_uc010otp.1_Missense_Mutation_p.H269Y|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.H30Y	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	342	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		AGATTTGTCTCATCCTCGACA	0.358													0	0	0	0.007291	0	13	76										T	94953306	C	T	94953306	3	4	59	1	0	0	0	0	1	0	0	0	62	826	29	1	1101	1	ABCD3	1	94953306	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	13	94953306	154297315	33	16836			2	66	61661053	3	3	50	C		2.652146e-07
ABCD3	5825	broad.mit.edu	37	chr1	94953342	94953342	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agagtacacattcggaacttCtagaggtaaactgatgataa	9	6	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:94953342C>G	uc001dqn.3	+	12	1162	c.1060C>G	c.(1060-1062)CTA>GTA	p.L354V	ABCD3_uc010oto.1_Missense_Mutation_p.L378V|ABCD3_uc010otp.1_Missense_Mutation_p.L281V|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.L42V	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	354	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTCGGAACTTCTAGAGGTAAA	0.333													0	0	0	0.008871	0	5	47										G	94953342	C	G	94953342	3	3	59	1	0	0	0	0	1	0	0	0	62	912	32	1	1137	1	ABCD3	1	94953342	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	36	94953342	154297279	34	16837			2	66	61661053	3	3	50	C		2.652146e-07
FNDC7	163479	broad.mit.edu	37	chr1	109265152	109265152	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tggaactgaatacttgatttCagttttagcaagtaatgatg	9	4	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:109265152C>T	uc001dvx.2	+	5	794	c.794C>T	c.(793-795)TCA>TTA	p.S265L	FNDC7_uc010ova.1_Missense_Mutation_p.S32L	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	266	Fibronectin type-III 3.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TACTTGATTTCAGTTTTAGCA	0.453													0	0	0	0.00245	0	14	44										T	109265152	C	T	109265152	3	4	59	1	0	0	0	0	1	0	0	0	5973	838	29	1	812	1	FNDC7	1	109265152	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	14311810	109265152	139985469	35	16838										
DRAM2	128338	broad.mit.edu	37	chr1	111674048	111674048	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agaatacatttcacttacctGatataaggtaaagccgggtc	8	8	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:111674048G>A	uc001ead.3	-	3	386	c.129C>T	c.(127-129)ATC>ATT	p.I43I	DRAM2_uc001eae.3_Silent_p.I43I|DRAM2_uc009wfy.2_RNA|DRAM2_uc001eaf.3_5'UTR	NM_178454	NP_848549	Q6UX65	DRAM2_HUMAN	transmembrane protein 77	43					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0						TCACTTACCTGATATAAGGTA	0.338													0	0	0	0.007413	0	16	69										A	111674048	G	A	111674048	2	1	59	1	0	0	0	0	0	0	0	1	4754	1280	45	1		1	DRAM2	1	111674048	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2408896	111674048	137576573	36	16839										
PRPF3	9129	broad.mit.edu	37	chr1	150307520	150307520	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acacaccgcatgcctactctGaaagccaatattcgtgctgt	7	13	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:150307520G>C	uc001eum.3	+	7	1005	c.843G>C	c.(841-843)CTG>CTC	p.L281L	PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Silent_p.L240L|PRPF3_uc010pcb.1_Silent_p.L232L|PRPF3_uc009wlq.1_RNA	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	281					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		TGCCTACTCTGAAAGCCAATA	0.473													0	0	0	0.013537	0	9	28										C	150307520	G	C	150307520	2	2	59	1	0	0	0	0	0	0	0	1	12565	1277	45	1		1	PRPF3	1	150307520	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	38633472	150307520	98943101	37	16840										
TCHH	7062	broad.mit.edu	37	chr1	152080083	152080083	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcccgttcctggcgacgtttCtgctcctcttcttgccatag	8	15	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:152080083C>G	uc001ezp.2	-	2	5610	c.5610G>C	c.(5608-5610)CAG>CAC	p.Q1870H	TCHH_uc009wne.1_Missense_Mutation_p.Q1870H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1870	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCGACGTTTCTGCTCCTCTT	0.582													0	0	0	0.003755	0	34	75										G	152080083	C	G	152080083	3	3	59	1	0	0	0	0	1	0	0	0	15697	912	32	1	225	1	TCHH	1	152080083	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1772563	152080083	97170538	38	16841										
FCRL2	79368	broad.mit.edu	37	chr1	157745580	157745580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctcacctgcctgttcagtgaCtgcatctgtgaggagatcaa	10	11	4	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:157745580C>T	uc001fre.2	-	2	96	c.37G>A	c.(37-39)GTC>ATC	p.V13I	FCRL2_uc010phz.1_Missense_Mutation_p.V13I|FCRL2_uc009wsp.2_Missense_Mutation_p.V13I|FCRL2_uc010pia.1_Missense_Mutation_p.V13I	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	13					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGTTCAGTGACTGCATCTGTG	0.428													0	0	0	0.007413	0	12	40										T	157745580	C	T	157745580	3	4	59	1	0	0	0	0	1	0	0	0	5795	565	20	2	1533	2	FCRL2	1	157745580	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5665497	157745580	91505041	39	16842										
VSIG8	391123	broad.mit.edu	37	chr1	159827692	159827692	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cccccactggcatagcacttCagcaccacatcgttgccata	6	17	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:159827692C>A	uc001fuh.2	-	4	631	c.495G>T	c.(493-495)CTG>CTT	p.L165L	C1orf204_uc001fuf.1_5'Flank|C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	165	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CATAGCACTTCAGCACCACAT	0.592													1	0	0.00010058	0.013537	0.000104042	11	38										A	159827692	C	A	159827692	2	1	59	1	0	0	0	0	0	0	0	1	17223	813	29	3		3	VSIG8	1	159827692	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2082112	159827692	89422929	40	16843										
PVRL4	81607	broad.mit.edu	37	chr1	161044087	161044087	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accaccagaaggcagaacaaGagtgcggcgatcacacccac	10	14	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:161044087G>C	uc001fxo.2	-	6	1376	c.1077C>G	c.(1075-1077)CTC>CTG	p.L359L	PVRL4_uc010pjy.1_Silent_p.L38L|PVRL4_uc010pjz.1_Silent_p.L93L	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	359	Helical; (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GGCAGAACAAGAGTGCGGCGA	0.602													0	0	0	0.01441	0	40	77										C	161044087	G	C	161044087	2	2	59	1	0	0	0	0	0	0	0	1	12842	929	33	1		1	PVRL4	1	161044087	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1216395	161044087	88206534	41	16844										
GPA33	10223	broad.mit.edu	37	chr1	167059489	167059489	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggggcctactcacctgcacaGagtgtccacaacacaggcca	10	15	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:167059489G>C	uc001gea.1	-	1	380	c.36C>G	c.(34-36)CTC>CTG	p.L12L		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	12						integral to plasma membrane	receptor activity				0						CACCTGCACAGAGTGTCCACA	0.582													0	0	0	0.001855	0	11	33										C	167059489	G	C	167059489	2	2	59	1	0	0	0	0	0	0	0	1	6586	929	33	1		1	GPA33	1	167059489	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6015402	167059489	82191132	42	16845										
FMO3	2328	broad.mit.edu	37	chr1	171076861	171076861	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atcctgattttgcaactactGgccagtgggatgttaccact	9	10	0	1	rs113006768		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:171076861G>A	uc001ghi.2	+	4	478	c.367G>A	c.(367-369)GGC>AGC	p.G123S	FMO3_uc001ghh.2_Missense_Mutation_p.G123S|FMO3_uc010pmb.1_Missense_Mutation_p.G103S|FMO3_uc010pmc.1_Missense_Mutation_p.G60S	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	123					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCAACTACTGGCCAGTGGGA	0.403													0	0	0	0.009535	0	25	64										A	171076861	G	A	171076861	3	1	59	1	0	0	0	0	1	0	0	0	5956	1348	47	2	377	2	FMO3	1	171076861	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4017372	171076861	78173760	43	16846										
RNASEL	6041	broad.mit.edu	37	chr1	182555827	182555827	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagcaattgctggaccaggtCaacatcttcgttttgaacag	9	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:182555827C>G	uc001gpj.1	-	1	282	c.115G>C	c.(115-117)GAC>CAC	p.D39H	RNASEL_uc009wxz.1_Missense_Mutation_p.D39H|RNASEL_uc001gpk.2_Missense_Mutation_p.D39H|RNASEL_uc009wya.1_Missense_Mutation_p.D39H	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	39	ANK 1.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TGGACCAGGTCAACATCTTCG	0.512									Hereditary_Prostate_Cancer				0	0	0	0.012213	0	30	119										G	182555827	C	G	182555827	3	3	59	1	0	0	0	0	1	0	0	0	13416	826	29	1	2134	1	RNASEL	1	182555827	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	11478966	182555827	66694794	44	16847										
EDEM3	80267	broad.mit.edu	37	chr1	184680990	184680990	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccaatcgaagttactgtcatCcagttctgtatattccgagg	8	10	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:184680990C>T	uc010pok.1	-	15	1819	c.1558G>A	c.(1558-1560)GAT>AAT	p.D520N	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.D520N	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	520					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TTACTGTCATCCAGTTCTGTA	0.299													0	0	0	0.008291	0	9	33										T	184680990	C	T	184680990	3	4	59	1	0	0	0	0	1	0	0	0	4913	855	30	1	1264	1	EDEM3	1	184680990	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2125163	184680990	64569631	45	16848										
ATP2B4	493	broad.mit.edu	37	chr1	203696675	203696675	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggccagatcctctggttccgGggcctgaaccgtatccagac	12	14	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:203696675G>A	uc001gzw.2	+	20	4169	c.3285G>A	c.(3283-3285)CGG>CGA	p.R1095R	ATP2B4_uc001gzv.2_Silent_p.R1095R|ATP2B4_uc009xaq.2_Silent_p.R1095R|ATP2B4_uc001gzx.2_Silent_p.R126R|ATP2B4_uc009xar.2_Silent_p.R90R|ATP2B4_uc010pqj.1_5'Flank|uc010pqk.1_5'Flank|SNORA77_uc001gzy.1_5'Flank	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1095	Cytoplasmic (Potential).|Calmodulin-binding subdomain A.				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCTGGTTCCGGGGCCTGAACC	0.562													0	0	0	0.01441	0	39	69										A	203696675	G	A	203696675	2	1	59	1	0	0	0	0	0	0	0	1	1142	1219	43	2		2	ATP2B4	1	203696675	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	19015685	203696675	45553946	46	16849										
CDK18	5129	broad.mit.edu	37	chr1	205492648	205492648	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttggcagagaccccccgcaGgagtgcagcaccttctcccc	10	18	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:205492648G>A	uc001hcr.2	+	3	387	c.168G>A	c.(166-168)CAG>CAA	p.Q56Q	CDK18_uc009xbk.1_RNA|CDK18_uc009xbl.1_RNA|CDK18_uc010pri.1_Missense_Mutation_p.G77R|CDK18_uc001hcp.2_Silent_p.Q56Q|CDK18_uc001hcq.2_Silent_p.Q56Q|CDK18_uc010prj.1_5'UTR|CDK18_uc001hcs.2_5'UTR|CDK18_uc009xbm.1_5'UTR	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	54							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity	p.Q56*(1)		stomach(2)	2						ACCCCCCGCAGGAGTGCAGCA	0.667													0	0	0	0.009096	0	3	19										A	205492648	G	A	205492648	2	1	59	1	0	0	0	0	0	0	0	1	3134	991	35	2		2	CDK18	1	205492648	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1795973	205492648	43757973	47	16850										
YOD1	55432	broad.mit.edu	37	chr1	207222498	207222498	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagtaaactgtctccttcttCtagcttcatctgctaattcc	4	13	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:207222498C>G	uc001hfe.1	-	2	961	c.914G>C	c.(913-915)AGA>ACA	p.R305T	PFKFB2_uc010psc.1_Intron|YOD1_uc001hff.1_Missense_Mutation_p.R261T	NM_018566	NP_061036	Q5VVQ6	OTU1_HUMAN	YOD1 OTU deubiquinating enzyme 1 homolog	305					cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1	Prostate(682;0.19)					TCTCCTTCTTCTAGCTTCATC	0.443													0	0	0	0.01441	0	56	135										G	207222498	C	G	207222498	3	3	59	1	0	0	0	0	1	0	0	0	17485	913	32	1	136	1	YOD1	1	207222498	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1729850	207222498	42028123	48	16851										
INTS7	25896	broad.mit.edu	37	chr1	212190291	212190291	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caacttctacattatcatgtGaatctaaactctgacgaata	4	9	4	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:212190291G>A	uc001hiw.1	-	4	551	c.446C>T	c.(445-447)TCA>TTA	p.S149L	INTS7_uc009xdb.1_Missense_Mutation_p.S149L|INTS7_uc001hix.1_Missense_Mutation_p.S25L|INTS7_uc001hiy.1_Missense_Mutation_p.S149L|INTS7_uc010pta.1_Missense_Mutation_p.S100L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	149					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ATTATCATGTGAATCTAAACT	0.388													0	0	0	0.013726	0	31	71										A	212190291	G	A	212190291	3	1	59	1	0	0	0	0	1	0	0	0	7783	1294	45	1	2510	1	INTS7	1	212190291	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4967793	212190291	37060330	49	16852										
HHIPL2	79802	broad.mit.edu	37	chr1	222715388	222715388	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccaaacaggccaaagggatCtccagcctgtcccccgtccc	8	18	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:222715388C>G	uc001hnh.1	-	3	1142	c.1084G>C	c.(1084-1086)GAT>CAT	p.D362H		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	362					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CCAAAGGGATCTCCAGCCTGT	0.532													0	0	0	0.008871	0	19	57										G	222715388	C	G	222715388	3	3	59	1	0	0	0	0	1	0	0	0	7094	913	32	1	1118	1	HHIPL2	1	222715388	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	10525097	222715388	26535233	50	16853										
HHIPL2	79802	broad.mit.edu	37	chr1	222716949	222716949	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctcactaattcggatcttttCtaccttcttcttgtccaggc	5	13	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:222716949C>G	uc001hnh.1	-	2	962	c.904G>C	c.(904-906)GAA>CAA	p.E302Q		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	302					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CGGATCTTTTCTACCTTCTTC	0.468													0	0	0	0.01441	0	84	231										G	222716949	C	G	222716949	3	3	59	1	0	0	0	0	1	0	0	0	7094	922	32	1	1302	1	HHIPL2	1	222716949	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1561	222716949	26533672	51	16854										
HHIPL2	79802	broad.mit.edu	37	chr1	222717298	222717298	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cggttgagatagtcgttcctCaggacattagggaagcaata	12	7	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:222717298C>T	uc001hnh.1	-	2	613	c.555G>A	c.(553-555)CTG>CTA	p.L185L		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	185					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		AGTCGTTCCTCAGGACATTAG	0.612													0	0	0	0.016522	0	22	50										T	222717298	C	T	222717298	2	4	59	1	0	0	0	0	0	0	0	1	7094	813	29	1		1	HHIPL2	1	222717298	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	349	222717298	26533323	52	16855										
FBXO28	23219	broad.mit.edu	37	chr1	224321837	224321837	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagacattcttgctgctgttGaaacaaggctgtcactatta	8	9	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:224321837G>C	uc001hoh.2	+	3	480	c.439G>C	c.(439-441)GAA>CAA	p.E147Q	FBXO28_uc009xef.2_Missense_Mutation_p.E147Q|FBXO28_uc010pvc.1_Intron	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	147										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		TGCTGCTGTTGAAACAAGGCT	0.358													0	0	0	0.004482	0	9	25										C	224321837	G	C	224321837	3	2	59	1	0	0	0	0	1	0	0	0	5738	1291	45	1	449	1	FBXO28	1	224321837	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1604539	224321837	24928784	53	16856										
PARP1	142	broad.mit.edu	37	chr1	226595555	226595555	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgagtccttggggatgctctCgctgcatttcttgcaagagg	13	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:226595555C>G	uc001hqd.3	-	1	247	c.76G>C	c.(76-78)GAG>CAG	p.E26Q		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	26	PARP-type 1.|				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GGGATGCTCTCGCTGCATTTC	0.507								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.004672	0	3	17										G	226595555	C	G	226595555	3	3	59	1	0	0	0	0	1	0	0	0	11454	893	31	1	3060	1	PARP1	1	226595555	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2273718	226595555	22655066	54	16857										
C1orf124	83932	broad.mit.edu	37	chr1	231474322	231474322	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggggccagctggaggccgtcGaggtgaagtggagcgtgcga	21	8	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:231474322G>C	uc001hur.2	+	1	641	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	EXOC8_uc001huq.2_5'Flank|C1orf124_uc001hus.2_Missense_Mutation_p.E65Q|C1orf124_uc001hut.2_Missense_Mutation_p.E65Q	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	65					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GGAGGCCGTCGAGGTGAAGTG	0.617													0	0	0	0.004289	0	32	133										C	231474322	G	C	231474322	3	2	59	1	0	0	0	0	1	0	0	0	1992	1059	37	1	195	1	C1orf124	1	231474322	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4878767	231474322	17776299	55	16858										
LYST	1130	broad.mit.edu	37	chr1	235894422	235894422	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctctctcgatttggcccttCtgttggatccaactgccatg	8	14	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:235894422C>T	uc001hxj.2	-	35	9032	c.8857G>A	c.(8857-8859)GAA>AAA	p.E2953K	LYST_uc001hxi.2_Missense_Mutation_p.E177K	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2953					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTGGCCCTTCTGTTGGATCC	0.408									Chediak-Higashi_syndrome				0	0	0	0.012319	0	21	35										T	235894422	C	T	235894422	3	4	59	1	0	0	0	0	1	0	0	0	9128	922	32	1	2624	1	LYST	1	235894422	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4420100	235894422	13356199	56	16859										
OR2T11	127077	broad.mit.edu	37	chr1	248790334	248790334	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttgcagtcacggcccccaaGaaaacagcaaggatcactgt	9	12	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:248790334G>C	uc001ier.1	-	1	96	c.96C>G	c.(94-96)TTC>TTG	p.F32L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGGCCCCCAAGAAAACAGCAA	0.498													0	0	0	0.006999	0	41	81										C	248790334	G	C	248790334	3	2	59	1	0	0	0	0	1	0	0	0	11018	933	33	1	858	1	OR2T11	1	248790334	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12895912	248790334	460287	57	16860										
MYT1L	23040	broad.mit.edu	37	chr2	1842969	1842969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgtggcctgagccgtcgcatCctggcgtggggcaggacatg	17	12	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:1842969C>T	uc002qxe.2	-	21	3859	c.3032G>A	c.(3031-3033)GGA>GAA	p.G1011E	MYT1L_uc002qxd.2_Missense_Mutation_p.G1009E|MYT1L_uc010ewk.2_Missense_Mutation_p.G7E	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1011	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCCGTCGCATCCTGGCGTGGG	0.667													0	0	0	0.013537	0	9	39										T	1842969	C	T	1842969	3	4	59	1	0	0	0	0	1	0	0	0	10107	855	30	1	548	1	MYT1L	2	1842969	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		1842969	241356404	58	16861										
ASAP2	8853	broad.mit.edu	37	chr2	9484706	9484706	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttatagcttacatcagcctCagggaaacaaggaacatggg	10	9	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:9484706C>A	uc002qzh.2	+	10	1235	c.895C>A	c.(895-897)CAG>AAG	p.Q299K	ASAP2_uc002qzi.2_Missense_Mutation_p.Q299K	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	299					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						ACATCAGCCTCAGGGAAACAA	0.458													1	0	2.2171e-23	0.009535	2.37987e-23	24	66										A	9484706	C	A	9484706	3	1	59	1	0	0	0	0	1	0	0	0	1011	827	29	3	933	3	ASAP2	2	9484706	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	7641737	9484706	233714667	59	16862										
NCOA1	8648	broad.mit.edu	37	chr2	24980905	24980905	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccaggagtatacaacaacatGagcatcaccgtttccatggc	8	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:24980905G>C	uc002rfk.2	+	19	4203	c.3945G>C	c.(3943-3945)ATG>ATC	p.M1315I	NCOA1_uc010eye.2_Missense_Mutation_p.M1315I|NCOA1_uc002rfi.2_Missense_Mutation_p.M1164I|NCOA1_uc002rfj.2_Missense_Mutation_p.M1315I|NCOA1_uc002rfl.2_Missense_Mutation_p.M1315I|NCOA1_uc010eyf.2_Missense_Mutation_p.M208I	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1315									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAACAACATGAGCATCACCG	0.473			T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.007413	0	20	55										C	24980905	G	C	24980905	3	2	59	1	0	0	0	0	1	0	0	0	10228	1290	45	1	4011	1	NCOA1	2	24980905	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	15496199	24980905	218218468	60	16863										
DTNB	1838	broad.mit.edu	37	chr2	25803618	25803618	+	Silent	SNP	G	G	A													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acatgggcaagcctgtgcatGagaggtagccagacaaggca							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:25803618G>A	uc002rgh.2	-	7	931	c.681C>T	c.(679-681)CTC>CTT	p.L227L	DTNB_uc010yko.1_Silent_p.L170L|DTNB_uc010ykp.1_Silent_p.L23L|DTNB_uc002rgo.2_Silent_p.L48L|DTNB_uc002rgi.2_Silent_p.L227L|DTNB_uc002rgj.2_Silent_p.L227L|DTNB_uc002rgk.2_Silent_p.L227L|DTNB_uc002rgl.2_Silent_p.L227L|DTNB_uc002rgq.2_Silent_p.L227L|DTNB_uc002rgm.2_Silent_p.L227L|DTNB_uc002rgn.2_Silent_p.L23L|DTNB_uc002rgr.1_Silent_p.L216L|DTNB_uc010ykq.1_Silent_p.L80L	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	227						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCTGTGCATGAGAGGTAGCC	0.398													0	0	0	0.012213	0	28	72										A	25803618	G	A	25803618	2	1	59	1	0	0	0	0	0	0	0	1	4789	1277	45	1		1	DTNB	2	25803618	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	822713	25803618	217395755	61	16864	82	2								
DTNB	1838	broad.mit.edu	37	chr2	25803620	25803620	+	Missense_Mutation	SNP	G	G	A													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atgggcaagcctgtgcatgaGaggtagccagacaaggcact					rs111695014	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:25803620G>A	uc002rgh.2	-	7	929	c.679C>T	c.(679-681)CTC>TTC	p.L227F	DTNB_uc010yko.1_Missense_Mutation_p.L170F|DTNB_uc010ykp.1_Missense_Mutation_p.L23F|DTNB_uc002rgo.2_Missense_Mutation_p.L48F|DTNB_uc002rgi.2_Missense_Mutation_p.L227F|DTNB_uc002rgj.2_Missense_Mutation_p.L227F|DTNB_uc002rgk.2_Missense_Mutation_p.L227F|DTNB_uc002rgl.2_Missense_Mutation_p.L227F|DTNB_uc002rgq.2_Missense_Mutation_p.L227F|DTNB_uc002rgm.2_Missense_Mutation_p.L227F|DTNB_uc002rgn.2_Missense_Mutation_p.L23F|DTNB_uc002rgr.1_Missense_Mutation_p.L216F|DTNB_uc010ykq.1_Missense_Mutation_p.L80F	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	227						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGTGCATGAGAGGTAGCCAG	0.398													0	0	0	0.015359	0	29	72										A	25803620	G	A	25803620	3	1	59	1	0	0	0	0	1	0	0	0	4789	942	33	1	1260	1	DTNB	2	25803620	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2	25803620	217395753	62	16865	82	2								
GCKR	2646	broad.mit.edu	37	chr2	27729747	27729747	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agagtgcatccacacctttgGtgctggtgggaccccagtcc	12	13	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:27729747G>C	uc002rky.2	+	12	1127	c.1061G>C	c.(1060-1062)GGT>GCT	p.G354A	GCKR_uc010ezd.2_Splice_Site_p.D354_splice|GCKR_uc010ylu.1_Missense_Mutation_p.G164A	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	354	SIS 2.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					CACACCTTTGGTGCTGGTGGG	0.552													0	0	0	0.01441	0	48	109										C	27729747	G	C	27729747	3	2	59	1	0	0	0	0	1	0	0	0	6294	1261	44	4	1107	4	GCKR	2	27729747	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1926127	27729747	215469626	63	16866										
CEBPZ	10153	broad.mit.edu	37	chr2	37449631	37449631	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttttttcactatctctgtttCtttgtctgcatcagtgaatt	5	8	5	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:37449631C>G	uc002rpz.2	-	4	1987	c.1957G>C	c.(1957-1959)GAA>CAA	p.E653Q		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	653					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				ATCTCTGTTTCTTTGTCTGCA	0.343													0	0	0	0.00245	0	13	40										G	37449631	C	G	37449631	3	3	59	1	0	0	0	0	1	0	0	0	3204	922	32	1	1259	1	CEBPZ	2	37449631	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9719884	37449631	205749742	64	16867										
PPM1B	5495	broad.mit.edu	37	chr2	44428664	44428664	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	taagaatggtatcagaactgGatttttgaaaattgatgaat	9	2	1	5			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:44428664G>A	uc002rtt.2	+	2	754	c.326G>A	c.(325-327)GGA>GAA	p.G109E	PPM1B_uc002rts.2_Missense_Mutation_p.G109E|PPM1B_uc002rtu.2_Missense_Mutation_p.G109E|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.G109E|PPM1B_uc002rtx.2_Missense_Mutation_p.G109E	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	109					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATCAGAACTGGATTTTTGAAA	0.403													0	0	0	0.004656	0	26	58										A	44428664	G	A	44428664	3	1	59	1	0	0	0	0	1	0	0	0	12336	1174	41	1	328	1	PPM1B	2	44428664	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6979033	44428664	198770709	65	16868										
MDH1	4190	broad.mit.edu	37	chr2	63824624	63824624	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccaagaagggaaggcatggaGagaaaagatttactgaaagc	13	5	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:63824624G>C	uc002scj.1	+	4	347	c.291G>C	c.(289-291)GAG>GAC	p.E97D	MDH1_uc010ypv.1_Missense_Mutation_p.E115D|MDH1_uc010ypw.1_Missense_Mutation_p.E2D	NM_005917	NP_005908	P40925	MDHC_HUMAN	cytosolic malate dehydrogenase	97					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			kidney(2)	2					NADH(DB00157)	AAGGCATGGAGAGAAAAGATT	0.443													0	0	0	0.001855	0	11	20										C	63824624	G	C	63824624	3	2	59	1	0	0	0	0	1	0	0	0	9408	933	33	1	305	1	MDH1	2	63824624	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	19395960	63824624	179374749	66	16869										
EMX1	2016	broad.mit.edu	37	chr2	73160999	73160999	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgagtccgagcagaagaaGaagggctcccatcacatcaa	10	12	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:73160999G>A	uc002sin.1	+	3	1167	c.789G>A	c.(787-789)AAG>AAA	p.K263K	EMX1_uc002sim.1_3'UTR	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	230						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGCAGAAGAAGAAGGGCTCCC	0.582													0	0	0	0.010729	0	10	41										A	73160999	G	A	73160999	2	1	59	1	0	0	0	0	0	0	0	1	5107	933	33	1		1	EMX1	2	73160999	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9336375	73160999	170038374	67	16870										
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315235	73315235	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caaaccagctactcttggccTtttcctccccactggatgag	7	15	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:73315235T>C	uc002siu.3	-	3	1752	c.1511A>G	c.(1510-1512)AAG>AGG	p.K504R	RAB11FIP5_uc002sit.3_Missense_Mutation_p.K426R	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	504					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						ACTCTTGGCCTTTTCCTCCCC	0.592													0	0	0	0.004672	0	3	113										C	73315235	T	C	73315235	3	2	59	1	0	0	0	0	1	0	0	0	12897	1609	56	5	462	5	RAB11FIP5	2	73315235	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	154236	73315235	169884138	68	16871										
C2orf78	388960	broad.mit.edu	37	chr2	74043174	74043174	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	attcccaatatgaaacggaaGaaaaatcaacctgagcttag	7	8	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:74043174G>C	uc002sjr.1	+	3	1945	c.1824G>C	c.(1822-1824)AAG>AAC	p.K608N		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	608	Lys-rich.									ovary(2)	2						TGAAACGGAAGAAAAATCAAC	0.453													0	0	0	0.007413	0	15	33										C	74043174	G	C	74043174	3	2	59	1	0	0	0	0	1	0	0	0	2195	933	33	1	1834	1	C2orf78	2	74043174	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	727939	74043174	169156199	69	16872										
POLR1A	25885	broad.mit.edu	37	chr2	86305287	86305287	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tagtttgtccatctcgctatCaaacacaatattgacgtggc	7	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:86305287C>T	uc002sqs.2	-	10	1586	c.1207G>A	c.(1207-1209)GAT>AAT	p.D403N	POLR1A_uc002sqv.2_Missense_Mutation_p.D403N	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	403					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						ATCTCGCTATCAAACACAATA	0.413													0	0	0	0.007413	0	18	47										T	86305287	C	T	86305287	3	4	59	1	0	0	0	0	1	0	0	0	12209	826	29	1	4055	1	POLR1A	2	86305287	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	12262113	86305287	156894086	70	16873										
KCNIP3	30818	broad.mit.edu	37	chr2	96047361	96047361	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	taggactttgtggttggcctCtccatcctgctgcggggcac	13	12	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:96047361C>T	uc002sup.2	+	6	580	c.465C>T	c.(463-465)CTC>CTT	p.L155L	KCNIP3_uc002suq.2_Silent_p.L129L	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	155	EF-hand 2.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		TGGTTGGCCTCTCCATCCTGC	0.522													0	0	0	0.014323	0	17	38										T	96047361	C	T	96047361	2	4	59	1	0	0	0	0	0	0	0	1	8041	900	32	1		1	KCNIP3	2	96047361	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9742074	96047361	147152012	71	16874										
DUSP2	1844	broad.mit.edu	37	chr2	96809649	96809649	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accccccggcgctgcttaacGaagtcaaaggcctcgtccag	10	16	1	0	rs147952657	byFrequency	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:96809649G>A	uc002svk.3	-	4	944	c.858C>T	c.(856-858)TTC>TTT	p.F286F		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	286	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				GCTGCTTAACGAAGTCAAAGG	0.617													0	0	0	0.013537	0	10	22										A	96809649	G	A	96809649	2	1	59	1	0	0	0	0	0	0	0	1	4819	1049	37	1		1	DUSP2	2	96809649	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	762288	96809649	146389724	72	16875										
PDCL3	79031	broad.mit.edu	37	chr2	101188178	101188178	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgataggaatctgcccacGatatttgtttacctggaagg	10	9	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:101188178G>A	uc002tao.2	+	5	607	c.495G>A	c.(493-495)ACG>ACA	p.T165T		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	165					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						ATCTGCCCACGATATTTGTTT	0.458													0	0	0	0.004878	0	34	236										A	101188178	G	A	101188178	2	1	59	1	0	0	0	0	0	0	0	1	11628	1045	37	1		1	PDCL3	2	101188178	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4378529	101188178	142011195	73	16876										
GCC2	9648	broad.mit.edu	37	chr2	109087226	109087226	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aagaagcaattttaaattatGagagtttacgagagattatg	9	2	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:109087226G>C	uc002tec.2	+	6	1595	c.1441G>C	c.(1441-1443)GAG>CAG	p.E481Q	GCC2_uc002ted.2_Missense_Mutation_p.E380Q	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	481	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						TTTAAATTATGAGAGTTTACG	0.333													0	0	0	0.00499	0	16	48										C	109087226	G	C	109087226	3	2	59	1	0	0	0	0	1	0	0	0	6286	1291	45	1	1463	1	GCC2	2	109087226	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7899048	109087226	134112147	74	16877										
GCC2	9648	broad.mit.edu	37	chr2	109089346	109089346	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttcagtaaaagagttggaaGaaaaaataggtaactatggt	10	3	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:109089346G>C	uc002tec.2	+	7	3005	c.2851G>C	c.(2851-2853)GAA>CAA	p.E951Q	GCC2_uc002ted.2_Missense_Mutation_p.E850Q	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	951	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AGAGTTGGAAGAAAAAATAGG	0.308													0	0	0	0.004482	0	9	22										C	109089346	G	C	109089346	3	2	59	1	0	0	0	0	1	0	0	0	6286	943	33	1	2877	1	GCC2	2	109089346	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2120	109089346	134110027	75	16878										
ANKRD57	65124	broad.mit.edu	37	chr2	110373639	110373639	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaccaaagtccaatgtatttGggtaaaaattgcttctttta	7	6	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:110373639G>C	uc002tfb.2	+	1	1729	c.1573G>C	c.(1573-1575)GGG>CGG	p.G525R	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.2_5'Flank|SEPT10_uc002tex.2_5'Flank|SEPT10_uc002tey.2_5'Flank|SEPT10_uc010ywv.1_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	ankyrin repeat domain 57	525											0						CAATGTATTTGGGTAAAAATT	0.448													0	0	0	0.00245	0	14	18										C	110373639	G	C	110373639	3	2	59	1	0	0	0	0	1	0	0	0	683	1348	47	4	1575	4	ANKRD57	2	110373639	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1284293	110373639	132825734	76	16879										
ACOXL	55289	broad.mit.edu	37	chr2	111562905	111562905	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaacaagagtgcaagattcaAtgccatgctggcagcactga	11	9	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:111562905A>G	uc002tgr.3	+	9	910	c.686A>G	c.(685-687)AAT>AGT	p.N229S	ACOXL_uc010fkc.2_Missense_Mutation_p.N229S|ACOXL_uc010yxk.1_Missense_Mutation_p.N229S	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	229					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						GCAAGATTCAATGCCATGCTG	0.458													0	0	0	0.008361	0	30	85										G	111562905	A	G	111562905	3	3	59	1	0	0	0	0	1	0	0	0	161	101	4	5	716	5	ACOXL	2	111562905	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	1189266	111562905	131636468	77	16880										
DBI	1622	broad.mit.edu	37	chr2	120128357	120128357	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcacgggcaaggccaagtggGatgcctggaatgagctgaaa	15	8	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120128357G>A	uc002tlv.2	+	3	293	c.169G>A	c.(169-171)GAT>AAT	p.D57N	DBI_uc010yyh.1_Missense_Mutation_p.D74N|DBI_uc010yyi.1_Missense_Mutation_p.D74N|DBI_uc010yyj.1_RNA|DBI_uc010yyk.1_Missense_Mutation_p.D99N|DBI_uc010yyl.1_Missense_Mutation_p.D74N|DBI_uc010yym.1_Missense_Mutation_p.D67N|DBI_uc010yyn.1_Missense_Mutation_p.D74N|DBI_uc002tlw.2_Missense_Mutation_p.D74N|DBI_uc010yyo.1_RNA|DBI_uc002tlx.2_Missense_Mutation_p.D58N	NM_001079862	NP_001073331	P07108	ACBP_HUMAN	diazepam binding inhibitor isoform 3	57	ACB.				transport		benzodiazepine receptor binding|fatty-acyl-CoA binding				0						GGCCAAGTGGGATGCCTGGAA	0.428													0	0	0	0.00308	0	5	34										A	120128357	G	A	120128357	3	1	59	1	0	0	0	0	1	0	0	0	4251	1174	41	1	485	1	DBI	2	120128357	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	8565452	120128357	123071016	78	16881										
SCTR	6344	broad.mit.edu	37	chr2	120204358	120204358	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaatgagccaagggctagttCaaaaaacagctggatctcca	10	9	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120204358C>G	uc002tma.2	-	11	1343	c.1117G>C	c.(1117-1119)GAA>CAA	p.E373Q	SCTR_uc002tlz.2_Missense_Mutation_p.E195Q	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	373	Helical; Name=7; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGGGCTAGTTCAAAAAACAGC	0.547													0	0	0	0.010504	0	21	57										G	120204358	C	G	120204358	3	3	59	1	0	0	0	0	1	0	0	0	13943	835	29	1	217	1	SCTR	2	120204358	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	76001	120204358	122995015	79	16882										
PCDP1	200373	broad.mit.edu	37	chr2	120413951	120413951	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tactcagagaagtgaaagatCaagcacaaccagcagagaag	10	8	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120413951C>G	uc002tmb.2	+	25	2662	c.1570C>G	c.(1570-1572)CAA>GAA	p.Q524E		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	810						cilium	calmodulin binding				0	Colorectal(110;0.196)					AGTGAAAGATCAAGCACAACC	0.488													0	0	0	0.00308	0	6	20										G	120413951	C	G	120413951	3	3	59	1	0	0	0	0	1	0	0	0	11572	827	29	1	1632	1	PCDP1	2	120413951	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	209593	120413951	122785422	80	16883										
TMEM177	80775	broad.mit.edu	37	chr2	120439083	120439083	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggctttgtggcctacgccttCtcccaggattctctcactca	8	15	4	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120439083C>T	uc010flg.1	+	2	1127	c.654C>T	c.(652-654)TTC>TTT	p.F218F	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Silent_p.F218F|TMEM177_uc002tmd.2_Silent_p.F218F|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	218	Helical; (Potential).					integral to membrane				ovary(1)	1	Colorectal(110;0.196)					CCTACGCCTTCTCCCAGGATT	0.612													0	0	0	0.003163	0	13	50										T	120439083	C	T	120439083	2	4	59	1	0	0	0	0	0	0	0	1	16091	912	32	1		1	TMEM177	2	120439083	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	25132	120439083	122760290	81	16884										
ARHGAP15	55843	broad.mit.edu	37	chr2	143913219	143913219	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccgatgtcgggaaggtcactGaacctgtaagtcaaataccc	10	11	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:143913219G>A	uc002tvm.3	+	2	311	c.160G>A	c.(160-162)GAA>AAA	p.E54K	ARHGAP15_uc010zbl.1_Missense_Mutation_p.E54K	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	54					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GAAGGTCACTGAACCTGTAAG	0.393													0	0	0	0.012319	0	19	58										A	143913219	G	A	143913219	3	1	59	1	0	0	0	0	1	0	0	0	866	1291	45	1	162	1	ARHGAP15	2	143913219	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	23474136	143913219	99286154	82	16885										
MBD5	55777	broad.mit.edu	37	chr2	149248116	149248116	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggcctggaaaattagtaagaGaagacgacgttcacaattca	10	7	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:149248116G>C	uc002twm.3	+	12	5204	c.4216G>C	c.(4216-4218)GAA>CAA	p.E1406Q	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.E1406Q|MBD5_uc002two.2_Missense_Mutation_p.E664Q|MBD5_uc002twp.2_Missense_Mutation_p.E456Q	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1406	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATTAGTAAGAGAAGACGACGT	0.403													0	0	0	0.008291	0	10	33										C	149248116	G	C	149248116	3	2	59	1	0	0	0	0	1	0	0	0	9347	943	33	1	4242	1	MBD5	2	149248116	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5334897	149248116	93951257	83	16886										
RBM43	375287	broad.mit.edu	37	chr2	152112060	152112060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaaataccttttttttctttGaatattacatatgcaactcc	3	8	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:152112060G>C	uc002txh.2	-	2	349	c.201C>G	c.(199-201)TTC>TTG	p.F67L		NM_198557	NP_940959	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	67	RRM.						nucleotide binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		TTTTTTCTTTGAATATTACAT	0.289													0	0	0	0.001984	0	6	86										C	152112060	G	C	152112060	3	2	59	1	0	0	0	0	1	0	0	0	13137	1281	45	1	884	1	RBM43	2	152112060	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2863944	152112060	91087313	84	16887										
FAP	2191	broad.mit.edu	37	chr2	163030297	163030297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atctctctgtgtagacagacGctataaaatatatgagaata	7	6	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:163030297G>A	uc002ucd.2	-	23	2178	c.1970C>T	c.(1969-1971)GCG>GTG	p.A657V	FAP_uc010fpc.2_Missense_Mutation_p.A206V|FAP_uc010zct.1_Missense_Mutation_p.A632V|FAP_uc010fpd.2_Missense_Mutation_p.A136V	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	657	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GTAGACAGACGCTATAAAATA	0.318													0	0	0	0.01441	0	40	130										A	163030297	G	A	163030297	3	1	59	1	0	0	0	0	1	0	0	0	5673	1101	38	2	328	2	FAP	2	163030297	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	10918237	163030297	80169076	85	16888										
TTN	7273	broad.mit.edu	37	chr2	179395756	179395756	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caccacgctgtaattgccctCatcggaagcctggactgaag	10	13	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:179395756C>T	uc010zfg.1	-	307	98106	c.97882G>A	c.(97882-97884)GAG>AAG	p.E32628K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E26323K|TTN_uc010zfi.1_Missense_Mutation_p.E26256K|TTN_uc010zfj.1_Missense_Mutation_p.E26131K|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33555							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATTGCCCTCATCGGAAGCC	0.478													0	0	0	0.01441	0	93	261										T	179395756	C	T	179395756	3	4	59	1	0	0	0	0	1	0	0	0	16732	835	29	1	2413	1	TTN	2	179395756	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	16365459	179395756	63803617	86	16889										
TTN	7273	broad.mit.edu	37	chr2	179421783	179421783	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcaacaatgtagcctgtaatCttgctacctccatcgaaagc	6	12	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:179421783C>G	uc010zfg.1	-	279	80618	c.80394G>C	c.(80392-80394)AAG>AAC	p.K26798N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K20493N|TTN_uc010zfi.1_Missense_Mutation_p.K20426N|TTN_uc010zfj.1_Missense_Mutation_p.K20301N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27725							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCTGTAATCTTGCTACCTC	0.443													0	0	0	0.013537	0	10	18										G	179421783	C	G	179421783	3	3	59	1	0	0	0	0	1	0	0	0	16732	912	32	1	20013	1	TTN	2	179421783	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	26027	179421783	63777590	87	16890										
ZNF804A	91752	broad.mit.edu	37	chr2	185802674	185802674	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctctggataggttaataagtGaagacaaaaaagagaaaatg	10	3	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:185802674G>A	uc002uph.2	+	4	3145	c.2551G>A	c.(2551-2553)GAA>AAA	p.E851K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	851						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GTTAATAAGTGAAGACAAAAA	0.348													0	0	0	0.008291	0	9	31										A	185802674	G	A	185802674	3	1	59	1	0	0	0	0	1	0	0	0	18167	1291	45	1	2565	1	ZNF804A	2	185802674	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6380891	185802674	57396699	88	16891										
CALCRL	10203	broad.mit.edu	37	chr2	188228182	188228182	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caacagagttacaaacaaatGagaagaacagatttttgtgt	8	5	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:188228182G>A	uc002upv.3	-	9	1096	c.548C>T	c.(547-549)TCA>TTA	p.S183L	CALCRL_uc010frt.2_Missense_Mutation_p.S183L	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	183	Helical; Name=2; (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			ACAAACAAATGAGAAGAACAG	0.368													0	0	0	0.007413	0	17	42										A	188228182	G	A	188228182	3	1	59	1	0	0	0	0	1	0	0	0	2580	1294	45	1	865	1	CALCRL	2	188228182	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2425508	188228182	54971191	89	16892										
DNAH7	56171	broad.mit.edu	37	chr2	196673469	196673469	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aactctctacgaatggttttGaaggcaggcaaatcatctaa	8	8	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:196673469G>C	uc002utj.3	-	53	10121	c.10020C>G	c.(10018-10020)TTC>TTG	p.F3340L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3340					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAATGGTTTTGAAGGCAGGCA	0.388													0	0	0	0.01441	0	38	94										C	196673469	G	C	196673469	3	2	59	1	0	0	0	0	1	0	0	0	4606	1281	45	1	2106	1	DNAH7	2	196673469	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	8445287	196673469	46525904	90	16893										
SPATS2L	26010	broad.mit.edu	37	chr2	201305422	201305422	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgcaacgctgcaccgtttctCtaactagatatcgcgtcatg	8	12	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:201305422C>T	uc002uvn.3	+	8	1055	c.703C>T	c.(703-705)CTA>TTA	p.L235L	SPATS2L_uc010fst.2_Silent_p.L235L|SPATS2L_uc002uvo.3_Silent_p.L175L|SPATS2L_uc002uvp.3_Silent_p.L235L|SPATS2L_uc002uvq.3_Silent_p.L166L|SPATS2L_uc002uvr.3_Silent_p.L235L|SPATS2L_uc010zhc.1_Silent_p.L265L	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	235						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						CACCGTTTCTCTAACTAGATA	0.373													0	0	0	0.010504	0	21	38										T	201305422	C	T	201305422	2	4	59	1	0	0	0	0	0	0	0	1	15019	912	32	1		1	SPATS2L	2	201305422	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4631953	201305422	41893951	91	16894										
CASP8	841	broad.mit.edu	37	chr2	202149751	202149751	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccatctatgagctgacatctCagttcactggtttgaagtgc	9	10	3	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202149751C>T	uc002uxr.1	+	9	1224	c.1015C>T	c.(1015-1017)CAG>TAG	p.Q339*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q356*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q324*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q398*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q324*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q255*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	339					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCTGACATCTCAGTTCACTGG	0.478										HNSCC(4;0.00038)			0	0	0	0.010771	0	38	109										T	202149751	C	T	202149751	4	4	59	1	0	0	0	0	0	1	0	0	2677	827	29	1	1322	1	CASP8	2	202149751	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	844329	202149751	41049622	92	16895										
ALS2CR12	130540	broad.mit.edu	37	chr2	202163981	202163981	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctctttggtttttctcagctCttctaattgcaaggtgtcac	7	10	5	0	rs150075649		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202163981C>T	uc010ftg.2	-	12	1366	c.922G>A	c.(922-924)GAG>AAG	p.E308K	ALS2CR12_uc002uya.3_Missense_Mutation_p.E308K|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	308	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TTTCTCAGCTCTTCTAATTGC	0.368													0	0	0	0.005443	0	25	67										T	202163981	C	T	202163981	3	4	59	1	0	0	0	0	1	0	0	0	553	922	32	1	431	1	ALS2CR12	2	202163981	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	14230	202163981	41035392	93	16896										
ALS2CR12	130540	broad.mit.edu	37	chr2	202164015	202164015	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtgtcactttgatgttgtttCaagagctcctaaaaacaatt	7	7	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202164015C>G	uc010ftg.2	-	12	1332	c.888G>C	c.(886-888)TTG>TTC	p.L296F	ALS2CR12_uc002uya.3_Missense_Mutation_p.L296F|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	296	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GATGTTGTTTCAAGAGCTCCT	0.378													0	0	0	0.003954	0	23	66										G	202164015	C	G	202164015	3	3	59	1	0	0	0	0	1	0	0	0	553	825	29	1	465	1	ALS2CR12	2	202164015	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	34	202164015	41035358	94	16897										
CDK15	65061	broad.mit.edu	37	chr2	202755540	202755540	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttacagtttcaggagtgaggCtaaagccagaaatgtgtgac	12	6	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202755540C>T	uc002uyt.2	+	13	1262	c.1213C>T	c.(1213-1215)CTA>TTA	p.L405L	CDK15_uc002uys.2_Silent_p.L360L|CDK15_uc010ftn.1_Silent_p.L360L|CDK15_uc002uyu.1_RNA	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	411							ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	AGGAGTGAGGCTAAAGCCAGA	0.443													0	0	0	0.010818	0	22	42										T	202755540	C	T	202755540	2	4	59	1	0	0	0	0	0	0	0	1	3131	796	28	2		2	CDK15	2	202755540	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	591525	202755540	40443833	95	16898										
PARD3B	117583	broad.mit.edu	37	chr2	206023472	206023472	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaacctgactgctgtgcactCtctctggagacaagcgagca	11	12	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023472C>G	uc002var.1	+	11	1668	c.1461C>G	c.(1459-1461)CTC>CTG	p.L487L	PARD3B_uc010fub.1_Silent_p.L487L|PARD3B_uc002vao.1_Silent_p.L487L|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Silent_p.L487L	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	487					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GCTGTGCACTCTCTCTGGAGA	0.463													0	0	0	0.004289	0	32	113										G	206023472	C	G	206023472	2	3	59	1	0	0	0	0	0	0	0	1	11444	900	32	1		1	PARD3B	2	206023472	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3267932	206023472	37175901	96	16899			3	67		4	4	127	C		1.101643e-09
PARD3B	117583	broad.mit.edu	37	chr2	206023538	206023538	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gattcaggttctgctggcctCggggtgagcttaaaagggaa	15	7	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023538C>A	uc002var.1	+	11	1734	c.1527C>A	c.(1525-1527)CTC>CTA	p.L509L	PARD3B_uc010fub.1_Silent_p.L509L|PARD3B_uc002vao.1_Silent_p.L509L|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Silent_p.L509L	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	509	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CTGCTGGCCTCGGGGTGAGCT	0.488													1	0	9.04412e-07	0.004656	9.42749e-07	19	69										A	206023538	C	A	206023538	2	1	59	1	0	0	0	0	0	0	0	1	11444	871	31	3		3	PARD3B	2	206023538	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	66	206023538	37175835	97	16900			3	67		4	4	127	C		1.101643e-09
PARD3B	117583	broad.mit.edu	37	chr2	206023564	206023564	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gagcttaaaagggaacaaatCcagagaaactggaacagact	10	7	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023564C>G	uc002var.1	+	11	1760	c.1553C>G	c.(1552-1554)TCC>TGC	p.S518C	PARD3B_uc010fub.1_Missense_Mutation_p.S518C|PARD3B_uc002vao.1_Missense_Mutation_p.S518C|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Missense_Mutation_p.S518C	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	518	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGGAACAAATCCAGAGAAACT	0.473													0	0	0	0.008871	0	13	60										G	206023564	C	G	206023564	3	3	59	1	0	0	0	0	1	0	0	0	11444	855	30	1	1595	1	PARD3B	2	206023564	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	26	206023564	37175809	98	16901			3	67		4	4	127	C		1.101643e-09
PARD3B	117583	broad.mit.edu	37	chr2	206023598	206023598	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acagacttggggatttttatCaaatccatcattcatggagg	9	7	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023598C>G	uc002var.1	+	11	1794	c.1587C>G	c.(1585-1587)ATC>ATG	p.I529M	PARD3B_uc010fub.1_Missense_Mutation_p.I529M|PARD3B_uc002vao.1_Missense_Mutation_p.I529M|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Missense_Mutation_p.I529M	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	529	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGATTTTTATCAAATCCATCA	0.453													0	0	0	0.004007	0	8	51										G	206023598	C	G	206023598	3	3	59	1	0	0	0	0	1	0	0	0	11444	816	29	1	1629	1	PARD3B	2	206023598	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	34	206023598	37175775	99	16902			3	67		4	4	127	C		1.101643e-09
PTH2R	5746	broad.mit.edu	37	chr2	209358298	209358298	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atagtgggaggcagggagatGatattctaatggagaagcct	15	4	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:209358298G>A	uc002vdb.2	+	13	1780	c.1567G>A	c.(1567-1569)GAT>AAT	p.D523N	PTH2R_uc010zjb.1_Missense_Mutation_p.D534N|PTH2R_uc010fuo.1_Intron	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	523	Cytoplasmic (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GCAGGGAGATGATATTCTAAT	0.493													0	0	0	0.00333	0	26	55										A	209358298	G	A	209358298	3	1	59	1	0	0	0	0	1	0	0	0	12760	1290	45	1	1617	1	PTH2R	2	209358298	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3334700	209358298	33841075	100	16903										
SPEG	10290	broad.mit.edu	37	chr2	220337739	220337739	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgtaagggggtccagcacatCttccgggtcctcagcaccac	11	15	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:220337739C>G	uc010fwg.2	+	16	4068	c.4068C>G	c.(4066-4068)ATC>ATG	p.I1356M		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1356	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCAGCACATCTTCCGGGTCC	0.667													0	0	0	0.00499	0	15	56										G	220337739	C	G	220337739	3	3	59	1	0	0	0	0	1	0	0	0	15035	903	32	1	4142	1	SPEG	2	220337739	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	10979441	220337739	22861634	101	16904										
SPHKAP	80309	broad.mit.edu	37	chr2	228855860	228855860	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttgatcaccagcaggctcctCtgggggctggctgttcccgt	13	13	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:228855860C>G	uc002vpq.2	-	11	4862	c.4815G>C	c.(4813-4815)CAG>CAC	p.Q1605H	SPHKAP_uc002vpp.2_Missense_Mutation_p.Q1576H|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1605						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCAGGCTCCTCTGGGGGCTGG	0.577													0	0	0	0.013537	0	12	36										G	228855860	C	G	228855860	3	3	59	1	0	0	0	0	1	0	0	0	15047	912	32	1	295	1	SPHKAP	2	228855860	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	8518121	228855860	14343513	102	16905										
SPHKAP	80309	broad.mit.edu	37	chr2	228882210	228882210	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcggtgatgctctcacagctCgactgcttggagacagagct	12	11	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:228882210C>G	uc002vpq.2	-	7	3407	c.3360G>C	c.(3358-3360)TCG>TCC	p.S1120S	SPHKAP_uc002vpp.2_Silent_p.S1120S|SPHKAP_uc010zlx.1_Silent_p.S1120S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1120						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTCACAGCTCGACTGCTTGG	0.542													0	0	0	0.00308	0	7	24										G	228882210	C	G	228882210	2	3	59	1	0	0	0	0	0	0	0	1	15047	871	31	1		1	SPHKAP	2	228882210	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	26350	228882210	14317163	103	16906										
EIF4E2	9470	broad.mit.edu	37	chr2	233431865	233431865	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atccgggacacacttcggcgAgtgcttaacctacctcccaa	8	15	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:233431865A>G	uc002vta.2	+	6	684	c.606A>G	c.(604-606)CGA>CGG	p.R202R	EIF4E2_uc002vtb.1_Silent_p.R202R|EIF4E2_uc010zmi.1_Silent_p.R157R	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	202					regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CACTTCGGCGAGTGCTTAACC	0.488													0	0	0	0.01441	0	49	146										G	233431865	A	G	233431865	2	3	59	1	0	0	0	0	0	0	0	1	5030	291	11	5		5	EIF4E2	2	233431865	Silent	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	4549655	233431865	9767508	104	16907										
ATP2B2	491	broad.mit.edu	37	chr3	10379906	10379906	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggaaccacaggatctggcccCgccgcagctcccgctccgcg	12	19	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:10379906C>T	uc003bvt.2	-	22	3813	c.3374G>A	c.(3373-3375)CGG>CAG	p.R1125Q	ATP2B2_uc003bvv.2_Missense_Mutation_p.R1080Q|ATP2B2_uc003bvw.2_Missense_Mutation_p.R1080Q|ATP2B2_uc003bvs.2_5'Flank|ATP2B2_uc010hdo.2_Missense_Mutation_p.R830Q	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1125	Calmodulin-binding subdomain A (By similarity).|Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GATCTGGCCCCGCCGCAGCTC	0.682													0	0	0	0.00245	0	12	233										T	10379906	C	T	10379906	3	4	59	1	0	0	0	0	1	0	0	0	1140	652	23	2	365	2	ATP2B2	3	10379906	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		10379906	187642524	105	16908										
ZNF385D	79750	broad.mit.edu	37	chr3	21706481	21706481	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcaaaggaggggctggtggaCggacaagggccgggagagca	21	7	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:21706481C>T	uc003cce.2	-	2	470	c.62G>A	c.(61-63)CGT>CAT	p.R21H	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	21						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGCTGGTGGACGGACAAGGGC	0.517													0	0	0	0.004007	0	15	45										T	21706481	C	T	21706481	3	4	59	1	0	0	0	0	1	0	0	0	17875	536	19	2	1153	2	ZNF385D	3	21706481	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	11326575	21706481	176315949	106	16909										
VILL	50853	broad.mit.edu	37	chr3	38042961	38042961	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccccaggtgtggtgcatccaGgacttacacaggcagcccgt	12	14	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:38042961G>A	uc003chj.2	+	12	1483	c.1197G>A	c.(1195-1197)CAG>CAA	p.Q399Q	VILL_uc003chl.2_Silent_p.Q399Q|VILL_uc010hgu.2_Silent_p.Q229Q	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	399					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GGTGCATCCAGGACTTACACA	0.602													0	0	0	0.013537	0	12	79										A	38042961	G	A	38042961	2	1	59	1	0	0	0	0	0	0	0	1	17162	991	35	2		2	VILL	3	38042961	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	16336480	38042961	159979469	107	16910			4	68		3	3	328	G		1.198717e-05
VILL	50853	broad.mit.edu	37	chr3	38043072	38043072	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggccgtgtccagtacatcctGtacctatggcaggtgtgcca	12	12	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:38043072G>T	uc003chj.2	+	12	1594	c.1308G>T	c.(1306-1308)CTG>CTT	p.L436L	VILL_uc003chl.2_Silent_p.L436L|VILL_uc010hgu.2_Silent_p.L266L	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	436	Gelsolin-like 4.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGTACATCCTGTACCTATGGC	0.607													1	0	1.33834e-09	0.007413	1.41414e-09	16	96										T	38043072	G	T	38043072	2	4	59	1	0	0	0	0	0	0	0	1	17162	1364	48	4		4	VILL	3	38043072	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	111	38043072	159979358	108	16911			4	68		3	3	328	G		1.198717e-05
VILL	50853	broad.mit.edu	37	chr3	38043288	38043288	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtcctagtacaggagcatgtGaccatgggcagcgagccccc	13	13	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:38043288G>A	uc003chj.2	+	13	1702	c.1416G>A	c.(1414-1416)GTG>GTA	p.V472V	VILL_uc003chl.2_Silent_p.V472V|VILL_uc010hgu.2_Silent_p.V302V	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	472					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGGAGCATGTGACCATGGGCA	0.607													0	0	0	0.013537	0	10	68										A	38043288	G	A	38043288	2	1	59	1	0	0	0	0	0	0	0	1	17162	1277	45	1		1	VILL	3	38043288	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	216	38043288	159979142	109	16912			4	68		3	3	328	G		1.198717e-05
WDR48	57599	broad.mit.edu	37	chr3	39135477	39135477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccactagctcttctaataatGaaaaaccaggagaacaggaa	7	9	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39135477G>A	uc003cit.2	+	18	1868	c.1858G>A	c.(1858-1860)GAA>AAA	p.E620K	WDR48_uc011ayt.1_Missense_Mutation_p.E611K|WDR48_uc011ayu.1_Missense_Mutation_p.E538K|WDR48_uc011ayv.1_Missense_Mutation_p.E345K|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	620					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTCTAATAATGAAAAACCAGG	0.383													0	0	0	0.008291	0	9	23										A	39135477	G	A	39135477	3	1	59	1	0	0	0	0	1	0	0	0	17298	1291	45	1	1928	1	WDR48	3	39135477	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1092189	39135477	158886953	110	16913										
WDR48	57599	broad.mit.edu	37	chr3	39135489	39135489	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctaataatgaaaaaccaggaGaacaggaaaaagaagaagat	9	4	0	5			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39135489G>A	uc003cit.2	+	18	1880	c.1870G>A	c.(1870-1872)GAA>AAA	p.E624K	WDR48_uc011ayt.1_Missense_Mutation_p.E615K|WDR48_uc011ayu.1_Missense_Mutation_p.E542K|WDR48_uc011ayv.1_Missense_Mutation_p.E349K|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	624					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AAAACCAGGAGAACAGGAAAA	0.388													0	0	0	0.006214	0	9	25										A	39135489	G	A	39135489	3	1	59	1	0	0	0	0	1	0	0	0	17298	943	33	1	1940	1	WDR48	3	39135489	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12	39135489	158886941	111	16914										
CCR8	1237	broad.mit.edu	37	chr3	39374203	39374203	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atgtttttcatcaccctcatGagtgtggacaggtacctggc	10	10	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39374203G>A	uc010hhr.2	+	2	519	c.381G>A	c.(379-381)ATG>ATA	p.M127I	CCR8_uc003cjm.2_Missense_Mutation_p.M44I	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	127	Helical; Name=3; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TCACCCTCATGAGTGTGGACA	0.512													0	0	0	0.01441	0	75	200										A	39374203	G	A	39374203	3	1	59	1	0	0	0	0	1	0	0	0	2947	1290	45	1	383	1	CCR8	3	39374203	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	238714	39374203	158648227	112	16915										
CCR8	1237	broad.mit.edu	37	chr3	39374254	39374254	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccgtgtatgccctaaaggtGaggacgatcaggatgggcac	15	9	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39374254G>A	uc010hhr.2	+	2	570	c.432G>A	c.(430-432)GTG>GTA	p.V144V	CCR8_uc003cjm.2_Silent_p.V61V	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	144	Cytoplasmic (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CCCTAAAGGTGAGGACGATCA	0.502													0	0	0	0.01441	0	65	197										A	39374254	G	A	39374254	2	1	59	1	0	0	0	0	0	0	0	1	2947	1277	45	1		1	CCR8	3	39374254	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	51	39374254	158648176	113	16916										
TRAK1	22906	broad.mit.edu	37	chr3	42242499	42242499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ataggcaacgtcgtcctcgaCaacaagaccaacagcatcat	7	13	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:42242499C>A	uc003cky.2	+	12	1596	c.1380C>A	c.(1378-1380)GAC>GAA	p.D460E	TRAK1_uc011azh.1_Missense_Mutation_p.D460E|TRAK1_uc011azi.1_Missense_Mutation_p.D460E|TRAK1_uc003ckz.3_Missense_Mutation_p.D386E|TRAK1_uc011azj.1_Missense_Mutation_p.D386E|TRAK1_uc003cla.2_Missense_Mutation_p.D402E	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	460	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TCGTCCTCGACAACAAGACCA	0.577													1	0	3.00307e-07	0.008361	3.14247e-07	29	86										A	42242499	C	A	42242499	3	1	59	1	0	0	0	0	1	0	0	0	16446	477	17	4	1542	4	TRAK1	3	42242499	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2868245	42242499	155779931	114	16917										
NKTR	4820	broad.mit.edu	37	chr3	42679601	42679601	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gagaaagtatagcgagagcaGatcatctttagattattctt	9	5	3	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:42679601G>C	uc003clo.2	+	13	2552	c.2405G>C	c.(2404-2406)AGA>ACA	p.R802T	NKTR_uc003clm.1_Missense_Mutation_p.R549T|NKTR_uc003clp.2_Missense_Mutation_p.R549T|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R692T|NKTR_uc003clr.1_Missense_Mutation_p.R549T|NKTR_uc003cls.2_Missense_Mutation_p.R502T	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	802	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AGCGAGAGCAGATCATCTTTA	0.423													0	0	0	0.004878	0	36	84										C	42679601	G	C	42679601	3	2	59	1	0	0	0	0	1	0	0	0	10448	942	33	1	2451	1	NKTR	3	42679601	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	437102	42679601	155342829	115	16918										
C3orf39	84892	broad.mit.edu	37	chr3	43121671	43121671	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tacgggcttgctcagcccggTccagatgggtgatgcccccc	13	15	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:43121671T>C	uc003cmq.1	-	2	1394	c.1253A>G	c.(1252-1254)GAC>GGC	p.D418G	C3orf39_uc003cmr.1_Missense_Mutation_p.D418G	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	418						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		CTCAGCCCGGTCCAGATGGGT	0.612													0	0	0	0.00308	0	6	24										C	43121671	T	C	43121671	3	2	59	1	0	0	0	0	1	0	0	0	2229	1667	58	5	493	5	C3orf39	3	43121671	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	442070	43121671	154900759	116	16919										
ZDHHC3	51304	broad.mit.edu	37	chr3	44968315	44968315	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttttttagcccatcttctctCttcctttttcaattgttcta	2	11	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:44968315C>T	uc003cod.2	-	8	1124	c.850G>A	c.(850-852)GAG>AAG	p.E284K	ZDHHC3_uc003cog.2_Missense_Mutation_p.E256K|ZDHHC3_uc011bad.1_Intron	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	284	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		CATCTTCTCTCTTCCTTTTTC	0.478													0	0	0	0.008291	0	9	52										T	44968315	C	T	44968315	3	4	59	1	0	0	0	0	1	0	0	0	17613	922	32	1	390	1	ZDHHC3	3	44968315	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1846644	44968315	153054115	117	16920										
DNAH1	25981	broad.mit.edu	37	chr3	52429361	52429361	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggtgttcaaagactccaactCcaccacacccctcatctttg	5	16	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:52429361C>G	uc011bef.1	+	69	11267	c.11006C>G	c.(11005-11007)TCC>TGC	p.S3669C	DNAH1_uc003ddv.2_Missense_Mutation_p.S527C	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3734	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GACTCCAACTCCACCACACCC	0.567													0	0	0	0.00499	0	12	44										G	52429361	C	G	52429361	3	3	59	1	0	0	0	0	1	0	0	0	4597	855	30	1	11276	1	DNAH1	3	52429361	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	7461046	52429361	145593069	118	16921										
PBRM1	55193	broad.mit.edu	37	chr3	52651349	52651349	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtcttctatcattccctcttCaccagcatatttgtcattgc	4	13	6	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:52651349C>T	uc003des.2	-	14	1759	c.1747G>A	c.(1747-1749)GAA>AAA	p.E583K	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E583K|PBRM1_uc003der.2_Missense_Mutation_p.E551K|PBRM1_uc003det.2_Missense_Mutation_p.E598K|PBRM1_uc003deu.2_Missense_Mutation_p.E598K|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E583K|PBRM1_uc010hmk.1_Missense_Mutation_p.E583K|PBRM1_uc003dey.2_Missense_Mutation_p.E583K|PBRM1_uc003dez.1_Missense_Mutation_p.E583K|PBRM1_uc003dfb.1_Missense_Mutation_p.E496K|PBRM1_uc003dfc.2_5'Flank	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	583	Bromo 4.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATTCCCTCTTCACCAGCATAT	0.443			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.004656	0	25	44										T	52651349	C	T	52651349	3	4	59	1	0	0	0	0	1	0	0	0	11491	835	29	1	3221	1	PBRM1	3	52651349	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	221988	52651349	145371081	119	16922										
FEZF2	55079	broad.mit.edu	37	chr3	62355901	62355901	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcacgtgaaaggcttcttgtCgttgtgggtgtgcatatgga	15	6	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:62355901C>G	uc003dlh.2	-	4	1444	c.1237G>C	c.(1237-1239)GAC>CAC	p.D413H	FEZF2_uc003dli.2_Missense_Mutation_p.D413H	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	413					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		GGCTTCTTGTCGTTGTGGGTG	0.522													0	0	0	0.006999	0	36	131										G	62355901	C	G	62355901	3	3	59	1	0	0	0	0	1	0	0	0	5826	884	31	1	146	1	FEZF2	3	62355901	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9704552	62355901	135666529	120	16923										
ADAMTS9	56999	broad.mit.edu	37	chr3	64507920	64507920	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtaaccaccgcatttccctAcgactcgggtaccatcctgc	7	16	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:64507920A>G	uc003dmg.2	-	39	5767	c.5735T>C	c.(5734-5736)GTA>GCA	p.V1912A	ADAMTS9_uc011bfo.1_Missense_Mutation_p.V1884A|ADAMTS9_uc011bfp.1_Missense_Mutation_p.V823A	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1912	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCATTTCCCTACGACTCGGGT	0.488													0	0	0	0.00632	0	23	84										G	64507920	A	G	64507920	3	3	59	1	0	0	0	0	1	0	0	0	273	391	14	5	76	5	ADAMTS9	3	64507920	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	2152019	64507920	133514510	121	16924										
RYBP	23429	broad.mit.edu	37	chr3	72428484	72428484	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttctctttgtcctgcttttCaactttctccttcttctcct	2	14	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:72428484C>G	uc003dpe.2	-	2	340	c.223G>C	c.(223-225)GAA>CAA	p.E75Q		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	85	Lys-rich.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		TCCTGCTTTTCAACTTTCTCC	0.418													0	0	0	0.006122	0	16	79										G	72428484	C	G	72428484	3	3	59	1	0	0	0	0	1	0	0	0	13766	835	29	1	445	1	RYBP	3	72428484	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	7920564	72428484	125593946	122	16925										
CADM2	253559	broad.mit.edu	37	chr3	86010672	86010672	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agaattaccagatcctgaccGaatggttgtgagtggtaggg	14	6	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:86010672G>A	uc003dqj.2	+	7	1444	c.818G>A	c.(817-819)CGA>CAA	p.R273Q	CADM2_uc003dqk.2_Missense_Mutation_p.R282Q|CADM2_uc003dql.2_Missense_Mutation_p.R275Q	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	273	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GATCCTGACCGAATGGTTGTG	0.413													0	0	0	0.01441	0	44	149										A	86010672	G	A	86010672	3	1	59	1	0	0	0	0	1	0	0	0	2567	1058	37	1	915	1	CADM2	3	86010672	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	13582188	86010672	112011758	123	16926										
ST3GAL6	10402	broad.mit.edu	37	chr3	98489793	98489793	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caaagccagcttttgcctctCtgctgaggtaaaaatatacc	7	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:98489793C>G	uc003dsz.2	+	3	396	c.160C>G	c.(160-162)CTG>GTG	p.L54V	ST3GAL6_uc003dsy.2_5'UTR|ST3GAL6_uc003dta.2_5'UTR|ST3GAL6_uc003dtb.2_Intron|ST3GAL6_uc003dtc.2_Missense_Mutation_p.L54V|ST3GAL6_uc010hpd.2_Missense_Mutation_p.L107V	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	54	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						TTTTGCCTCTCTGCTGAGGTA	0.353													0	0	0	0.00308	0	7	41										G	98489793	C	G	98489793	3	3	59	1	0	0	0	0	1	0	0	0	15218	912	32	1	166	1	ST3GAL6	3	98489793	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	12479121	98489793	99532637	124	16927										
KPNA1	3836	broad.mit.edu	37	chr3	122152626	122152626	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggctgggaaaatgttggcatCtatcacagtctaaaattaaa	9	6	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:122152626C>T	uc003efd.1	-	12	1168	c.1132G>A	c.(1132-1134)GAT>AAT	p.D378N	KPNA1_uc003efb.1_Missense_Mutation_p.D177N|KPNA1_uc003efc.1_Missense_Mutation_p.D177N|KPNA1_uc011bjr.1_Missense_Mutation_p.D177N|KPNA1_uc010hrh.2_Missense_Mutation_p.D177N|KPNA1_uc003efe.2_Missense_Mutation_p.D378N	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	378	ARM 8.|Binding to RAG1.|NLS binding site (minor) (By similarity).				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		ATGTTGGCATCTATCACAGTC	0.323													0	0	0	0.001168	0	5	31										T	122152626	C	T	122152626	3	4	59	1	0	0	0	0	1	0	0	0	8429	913	32	1	496	1	KPNA1	3	122152626	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	23662833	122152626	75869804	125	16928										
KALRN	8997	broad.mit.edu	37	chr3	124356151	124356151	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agttggtcaaaaacaagctgGtaagtgggggtcctggaggc	16	6	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:124356151G>A	uc003ehg.2	+	37	5788	c.5661_splice	c.e37+1	p.L1887_splice	KALRN_uc003ehi.2_Intron|KALRN_uc003ehk.2_Splice_Site_p.L190_splice|KALRN_uc011bjz.1_Splice_Site|KALRN_uc003ehj.2_Intron	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AAACAAGCTGGTAAGTGGGGG	0.522													0	0	0	0.008291	0	8	66										A	124356151	G	A	124356151	5	1	59	1	0	0	0	0	0	0	1	0	7975	1275	44	2	5964	2	KALRN	3	124356151	Splice_Site	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2203525	124356151	73666279	126	16929										
BFSP2	8419	broad.mit.edu	37	chr3	133166243	133166243	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcagatgactttaaagagaGgtaatgtcttacagcagagg	12	5	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:133166243G>A	uc003epn.1	+	2	710	c.572G>A	c.(571-573)AGA>AAA	p.R191K	uc003epo.2_Intron	NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	191	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						TTTAAAGAGAGGTAATGTCTT	0.522													0	0	0	0.003163	0	13	22										A	133166243	G	A	133166243	3	1	59	1	0	0	0	0	1	0	0	0	1416	1014	35	2	578	2	BFSP2	3	133166243	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	8810092	133166243	64856187	127	16930										
TOPBP1	11073	broad.mit.edu	37	chr3	133374177	133374177	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgtgtacattcattcattttCaattgtcccatgtattgacc	5	9	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:133374177C>T	uc003eps.2	-	6	831	c.699G>A	c.(697-699)TTG>TTA	p.L233L		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	233	BRCT 2.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						CATTCATTTTCAATTGTCCCA	0.363								Other_conserved_DNA_damage_response_genes					0	0	0	0.006999	0	34	77										T	133374177	C	T	133374177	2	4	59	1	0	0	0	0	0	0	0	1	16366	825	29	1		1	TOPBP1	3	133374177	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	207934	133374177	64648253	128	16931										
TXNDC6	347736	broad.mit.edu	37	chr3	138024920	138024920	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctcttcatttgttagaatttCaaacccagcttcctgaatct	4	11	4	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:138024920C>G	uc003esg.2	-	8	590	c.562G>C	c.(562-564)GAA>CAA	p.E188Q	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Missense_Mutation_p.E103Q|TXNDC6_uc003ese.1_Missense_Mutation_p.E127Q	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	188	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						GTTAGAATTTCAAACCCAGCT	0.353													0	0	0	0.013537	0	11	66										G	138024920	C	G	138024920	3	3	59	1	0	0	0	0	1	0	0	0	16797	835	29	1	428	1	TXNDC6	3	138024920	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4650743	138024920	59997510	129	16932										
MRPS22	56945	broad.mit.edu	37	chr3	139062950	139062950	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aacgggtctgtttccgggctCgaatccagccctggcacggt	13	13	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:139062950C>G	uc003etb.2	+	1	90	c.82C>G	c.(82-84)CGA>GGA	p.R28G	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.R28G|MRPS22_uc003ete.2_5'Flank	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	28						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						TTTCCGGGCTCGAATCCAGCC	0.617													0	0	0	0.009096	0	4	22										G	139062950	C	G	139062950	3	3	59	1	0	0	0	0	1	0	0	0	9833	876	31	1	84	1	MRPS22	3	139062950	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1038030	139062950	58959480	130	16933										
COPB2	9276	broad.mit.edu	37	chr3	139087069	139087069	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctttttctgacagatacttaAggataaaaaatgattcctca	5	7	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:139087069A>G	uc003etf.3	-	13	1593	c.1463T>C	c.(1462-1464)CTT>CCT	p.L488P	COPB2_uc011bmv.1_Missense_Mutation_p.L459P|COPB2_uc010hui.2_Missense_Mutation_p.L459P	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	488					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CAGATACTTAAGGATAAAAAA	0.393													0	0	0	0.006214	0	9	52										G	139087069	A	G	139087069	3	3	59	1	0	0	0	0	1	0	0	0	3729	72	3	5	1297	5	COPB2	3	139087069	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	24119	139087069	58935361	131	16934										
MME	4311	broad.mit.edu	37	chr3	154855989	154855989	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaccagcttgctttggaaatGaataaagttatggaattgga	10	4	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:154855989G>C	uc010hvr.1	+	9	1030	c.819G>C	c.(817-819)ATG>ATC	p.M273I	MME_uc003fab.1_Missense_Mutation_p.M273I|MME_uc003fac.1_Missense_Mutation_p.M273I|MME_uc003fad.1_Missense_Mutation_p.M273I|MME_uc003fae.1_Missense_Mutation_p.M273I	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	273	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTTTGGAAATGAATAAAGTTA	0.358													0	0	0	0.001855	0	14	73										C	154855989	G	C	154855989	3	2	59	1	0	0	0	0	1	0	0	0	9645	1290	45	1	849	1	MME	3	154855989	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	15768920	154855989	43166441	132	16935										
ZBBX	79740	broad.mit.edu	37	chr3	167016138	167016138	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	attgttgcattctaaacgatGagaaggaagtaagttgagtc	11	4	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:167016138G>T	uc003fep.2	-	18	2157	c.1834C>A	c.(1834-1836)CAT>AAT	p.H612N	ZBBX_uc011bpc.1_Missense_Mutation_p.H612N|ZBBX_uc003feq.2_Missense_Mutation_p.H583N	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	612						intracellular	zinc ion binding			ovary(2)	2						TCTAAACGATGAGAAGGAAGT	0.333													1	0	1.52009e-12	0.003163	1.61566e-12	14	66										T	167016138	G	T	167016138	3	4	59	1	0	0	0	0	1	0	0	0	17513	1290	45	3	584	3	ZBBX	3	167016138	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12160149	167016138	31006292	133	16936										
LRRC31	79782	broad.mit.edu	37	chr3	169557820	169557820	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcttctttttttatcttggtCaaagcattctagttcttcct	5	9	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:169557820C>G	uc003fgc.1	-	9	1686	c.1609G>C	c.(1609-1611)GAC>CAC	p.D537H	LRRC31_uc010hwp.1_Missense_Mutation_p.D481H	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	537										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTATCTTGGTCAAAGCATTCT	0.403													0	0	0	0.012319	0	20	51										G	169557820	C	G	169557820	3	3	59	1	0	0	0	0	1	0	0	0	8986	826	29	1	53	1	LRRC31	3	169557820	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2541682	169557820	28464610	134	16937										
ATP11B	23200	broad.mit.edu	37	chr3	182566341	182566341	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cacagaaacgatctgcagtaGaaaagtaagaaaactgtttt	8	6	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:182566341G>C	uc003flb.2	+	10	1104	c.847G>C	c.(847-849)GAA>CAA	p.E283Q		NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	283	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATCTGCAGTAGAAAAGTAAGA	0.249													0	0	0	0.001855	0	13	35										C	182566341	G	C	182566341	3	2	59	1	0	0	0	0	1	0	0	0	1120	943	33	1	885	1	ATP11B	3	182566341	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	13008521	182566341	15456089	135	16938										
PSMD2	5708	broad.mit.edu	37	chr3	184026528	184026528	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtgggccaggctggcaagccGaagactatcacagggttcca	14	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:184026528G>A	uc003fnn.1	+	21	2610	c.2577G>A	c.(2575-2577)CCG>CCA	p.P859P	PSMD2_uc011brj.1_Silent_p.P700P|PSMD2_uc011brk.1_Silent_p.P729P	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	859					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	CTGGCAAGCCGAAGACTATCA	0.547											OREG0015948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006999	0	35	53										A	184026528	G	A	184026528	2	1	59	1	0	0	0	0	0	0	0	1	12698	1045	37	1		1	PSMD2	3	184026528	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1460187	184026528	13995902	136	16939										
EIF4A2	1974	broad.mit.edu	37	chr3	186504931	186504932	+	Frame_Shift_Del	DEL	AC	AC	-													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tacaggaatggaagttggatAcactttgtgacttgtacgag							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:186504931_186504932delAC	uc003fqs.2	+	8	826_827	c.787_788delAC	c.(787-789)ACAfs	p.T263fs	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Frame_Shift_Del_p.T264fs|EIF4A2_uc003fqv.2_Frame_Shift_Del_p.T168fs|EIF4A2_uc003fqw.2_Frame_Shift_Del_p.T168fs|EIF4A2_uc011bsb.1_Frame_Shift_Del_p.T136fs|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	263	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		GAAGTTGGATACACTTTGTGAC	0.361			T	BCL6	NHL													56	178	---	---								-	186504932	AC	-	186504931	7	5	59	1	0	1	0	1	0	0	0	0	5025	391	14	0	817	0	EIF4A2	3	186504931	Frame_Shift_Del	DEL	AC	TCGA-DK-A3IN-01A-11D-A20D-08	2478403	186504931	11517499	137	16940										
TCTEX1D2	255758	broad.mit.edu	37	chr3	196044975	196044975	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccctgcgttcttctcagcctCaggcaccccgtcgcccaccg	8	21	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:196044975C>T	uc003fwi.2	-	1	185	c.49G>A	c.(49-51)GAG>AAG	p.E17K	TM4SF19_uc003fwj.2_Intron|uc003fwk.1_5'Flank	NM_152773	NP_689986	Q8WW35	TC1D2_HUMAN	Tctex1 domain containing 2	17							protein binding			ovary(1)|breast(1)	2	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		TTCTCAGCCTCAGGCACCCCG	0.662													0	0	0	0.009096	0	3	10										T	196044975	C	T	196044975	3	4	59	1	0	0	0	0	1	0	0	0	15717	835	29	1	399	1	TCTEX1D2	3	196044975	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9540044	196044975	1977455	138	16941										
PIGG	54872	broad.mit.edu	37	chr4	499705	499705	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caacctcatttttcgtgtcaGattacacagaggtcagtttt	7	9	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:499705G>C	uc003gak.3	+	3	695	c.559G>C	c.(559-561)GAT>CAT	p.D187H	PIGG_uc003gaj.3_Missense_Mutation_p.D187H|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Intron|PIGG_uc003gal.3_Missense_Mutation_p.D98H|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.D65H|PIGG_uc003gam.2_Missense_Mutation_p.D98H|PIGG_uc003gan.2_Missense_Mutation_p.D98H	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	187	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TTTCGTGTCAGATTACACAGA	0.338													0	0	0	0.014758	0	5	29										C	499705	G	C	499705	3	2	59	1	0	0	0	0	1	0	0	0	11888	942	33	1	569	1	PIGG	4	499705	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		499705	190654571	139	16942										
CC2D2A	57545	broad.mit.edu	37	chr4	15601285	15601285	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtcaaggagaagatgtagaaGatgaccacagagcagaactg	13	6	1	7			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:15601285G>C	uc010idv.2	+	37	4875	c.4630G>C	c.(4630-4632)GAT>CAT	p.D1544H	CC2D2A_uc003gnx.2_Missense_Mutation_p.D1436H|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1544					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						AGATGTAGAAGATGACCACAG	0.443													0	0	0	0.00499	0	16	22										C	15601285	G	C	15601285	3	2	59	1	0	0	0	0	1	0	0	0	2728	942	33	1	4971	1	CC2D2A	4	15601285	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	15101580	15601285	175552991	140	16943										
LDB2	9079	broad.mit.edu	37	chr4	16597454	16597454	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caggtcggtcacccctccttCaaacacagtgctaaagtaac	7	14	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:16597454C>G	uc003goz.2	-	3	596	c.280G>C	c.(280-282)GAA>CAA	p.E94Q	LDB2_uc003gpa.2_Missense_Mutation_p.E94Q|LDB2_uc003gpb.2_Missense_Mutation_p.E94Q|LDB2_uc011bxh.1_Missense_Mutation_p.E94Q|LDB2_uc010iee.2_Missense_Mutation_p.E94Q|LDB2_uc003goy.2_5'UTR|LDB2_uc011bxi.1_5'UTR	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	94							LIM domain binding|transcription cofactor activity				0						ACCCCTCCTTCAAACACAGTG	0.493													0	0	0	0.01441	0	53	40										G	16597454	C	G	16597454	3	3	59	1	0	0	0	0	1	0	0	0	8696	835	29	1	974	1	LDB2	4	16597454	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	996169	16597454	174556822	141	16944										
ARAP2	116984	broad.mit.edu	37	chr4	36152544	36152544	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtatttaaatagaagtcctCtttgtgtatagccaggcaga	9	6	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:36152544C>G	uc003gsq.1	-	16	3213	c.2875G>C	c.(2875-2877)GAG>CAG	p.E959Q		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	959	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TAGAAGTCCTCTTTGTGTATA	0.343													0	0	0	0.01441	0	58	117										G	36152544	C	G	36152544	3	3	59	1	0	0	0	0	1	0	0	0	839	922	32	1	2311	1	ARAP2	4	36152544	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	19555090	36152544	155001732	142	16945										
GABRG1	2565	broad.mit.edu	37	chr4	46060594	46060594	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	taggatcagccacttctacgGagggctttttccacttatac	8	11	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:46060594G>A	uc003gxb.2	-	6	823	c.671C>T	c.(670-672)TCC>TTC	p.S224F		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	224	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CACTTCTACGGAGGGCTTTTT	0.358													0	0	0	0.001168	0	5	27										A	46060594	G	A	46060594	3	1	59	1	0	0	0	0	1	0	0	0	6171	1174	41	1	742	1	GABRG1	4	46060594	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9908050	46060594	145093682	143	16946										
KIAA1211	57482	broad.mit.edu	37	chr4	57181751	57181751	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggaccagttgaggcccggtGatgagtccactcccaggggc	16	12	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:57181751G>A	uc003hbk.2	+	8	2474	c.2083G>A	c.(2083-2085)GAT>AAT	p.D695N	KIAA1211_uc010iha.2_Missense_Mutation_p.D688N|KIAA1211_uc011bzz.1_Missense_Mutation_p.D605N|KIAA1211_uc003hbm.1_Missense_Mutation_p.D581N	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	695										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GAGGCCCGGTGATGAGTCCAC	0.592													0	0	0	0.00632	0	22	97										A	57181751	G	A	57181751	3	1	59	1	0	0	0	0	1	0	0	0	8215	1290	45	1	2101	1	KIAA1211	4	57181751	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	11121157	57181751	133972525	144	16947										
SRP72	6731	broad.mit.edu	37	chr4	57367868	57367868	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agggatgccagtaaaactgtGagcagcccacccacctcccc	9	16	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:57367868G>C	uc003hbv.2	+	19	1897	c.1857G>C	c.(1855-1857)GTG>GTC	p.V619V	SRP72_uc010ihe.2_Silent_p.V558V|SRP72_uc003hbx.2_RNA	NM_006947	NP_008878	O76094	SRP72_HUMAN	signal recognition particle 72kDa	619					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			ovary(1)	1	Glioma(25;0.08)|all_neural(26;0.101)					GTAAAACTGTGAGCAGCCCAC	0.453													0	0	0	0.014758	0	5	36										C	57367868	G	C	57367868	2	2	59	1	0	0	0	0	0	0	0	1	15156	1277	45	1		1	SRP72	4	57367868	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	186117	57367868	133786408	145	16948										
PTPN13	5783	broad.mit.edu	37	chr4	87694009	87694009	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaatctgcttcctctagttcGatggataagtatcatataca	7	8	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:87694009G>A	uc003hpz.2	+	32	5727	c.5247G>A	c.(5245-5247)TCG>TCA	p.S1749S	PTPN13_uc003hpy.2_Silent_p.S1754S|PTPN13_uc003hqa.2_Silent_p.S1730S|PTPN13_uc003hqb.2_Silent_p.S1558S|PTPN13_uc003hqc.1_Silent_p.S115S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1749	Poly-Ser.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CCTCTAGTTCGATGGATAAGT	0.408													0	0	0	0.00499	0	18	98										A	87694009	G	A	87694009	2	1	59	1	0	0	0	0	0	0	0	1	12782	1045	37	1		1	PTPN13	4	87694009	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	30326141	87694009	103460267	146	16949										
ADH6	130	broad.mit.edu	37	chr4	100129920	100129920	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aatgggtttctttaagtcctGagggttgaggcactcagtag	13	6	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:100129920G>C	uc003hup.3	-	6	827	c.733C>G	c.(733-735)CAG>GAG	p.Q245E	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.Q245E|ADH6_uc011cef.1_Missense_Mutation_p.Q36E|ADH6_uc010ile.2_Missense_Mutation_p.Q245E	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	245					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTTAAGTCCTGAGGGTTGAGG	0.438													0	0	0	0.01441	0	53	257										C	100129920	G	C	100129920	3	2	59	1	0	0	0	0	1	0	0	0	312	1299	45	1	414	1	ADH6	4	100129920	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12435911	100129920	91024356	147	16950										
NDST4	64579	broad.mit.edu	37	chr4	115760536	115760536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtaatttcaggacattacctGagaagtagcaaagtaagtta	9	5	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:115760536G>C	uc003ibu.2	-	11	2963	c.2284C>G	c.(2284-2286)CAG>GAG	p.Q762E	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	762	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GACATTACCTGAGAAGTAGCA	0.328													0	0	0	0.010818	0	29	63										C	115760536	G	C	115760536	3	2	59	1	0	0	0	0	1	0	0	0	10258	1299	45	1	350	1	NDST4	4	115760536	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	15630616	115760536	75393740	148	16951										
IL21	59067	broad.mit.edu	37	chr4	123542141	123542141	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcagacagatgacaatcctcTccatgttgccaggactggat	9	11	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:123542141T>A	uc003ies.2	-	1	71	c.26A>T	c.(25-27)GAG>GTG	p.E9V	uc003iet.2_RNA|IL21_uc010int.2_Missense_Mutation_p.E2V	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	2					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						GACAATCCTCTCCATGTTGCC	0.463													0	0	0	0.00499	0	14	95										A	123542141	T	A	123542141	3	1	59	1	0	0	0	0	1	0	0	0	7670	1551	54	5	482	5	IL21	4	123542141	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	7781605	123542141	67612135	149	16952										
MFSD8	256471	broad.mit.edu	37	chr4	128851881	128851881	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	taagaaaataacaacggcttCaaccccaagagcagcaagta	7	10	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:128851881C>T	uc003ifp.2	-	10	1118	c.955G>A	c.(955-957)GAA>AAA	p.E319K	MFSD8_uc011cgu.1_Missense_Mutation_p.E274K|MFSD8_uc011cgv.1_Missense_Mutation_p.E281K|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	319	Helical; (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						ACAACGGCTTCAACCCCAAGA	0.318													0	0	0	0.01441	0	49	124										T	128851881	C	T	128851881	3	4	59	1	0	0	0	0	1	0	0	0	9538	835	29	1	617	1	MFSD8	4	128851881	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5309740	128851881	62302395	150	16953										
PCDH18	54510	broad.mit.edu	37	chr4	138451064	138451064	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggatctagtgtctttcttctCgcggttacacctagttgcaa	9	10	4	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:138451064C>T	uc003ihe.3	-	1	2566	c.2179G>A	c.(2179-2181)GAG>AAG	p.E727K	PCDH18_uc003ihf.3_Missense_Mutation_p.E720K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E507K|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	727	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TCTTTCTTCTCGCGGTTACAC	0.458													0	0	0	0.006122	0	18	45										T	138451064	C	T	138451064	3	4	59	1	0	0	0	0	1	0	0	0	11513	893	31	1	1244	1	PCDH18	4	138451064	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9599183	138451064	52703212	151	16954										
FBXW7	55294	broad.mit.edu	37	chr4	153244235	153244235	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gttttacagttccatcatctGagctggtaattacaaagttc	7	8	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:153244235G>C	uc003ims.2	-	12	2071	c.1922C>G	c.(1921-1923)TCA>TGA	p.S641*	FBXW7_uc011cii.1_Nonsense_Mutation_p.S641*|FBXW7_uc003imt.2_Nonsense_Mutation_p.S641*|FBXW7_uc011cih.1_Nonsense_Mutation_p.S465*|FBXW7_uc003imq.2_Nonsense_Mutation_p.S561*|FBXW7_uc003imr.2_Nonsense_Mutation_p.S523*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	641	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TCCATCATCTGAGCTGGTAAT	0.428			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.006214	0	10	72										C	153244235	G	C	153244235	4	2	59	1	0	0	0	0	0	1	0	0	5769	1294	45	1	205	1	FBXW7	4	153244235	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	14793171	153244235	37910041	152	16955										
FGA	2243	broad.mit.edu	37	chr4	155507290	155507290	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttagaagtgaccagtttttCtgtgtggtactctctccttg	9	8	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:155507290C>T	uc003iod.1	-	5	1349	c.1291G>A	c.(1291-1293)GAA>AAA	p.E431K	FGA_uc003ioe.1_Missense_Mutation_p.E431K|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	431	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ACCAGTTTTTCTGTGTGGTAC	0.507													0	0	0	0.006999	0	37	106										T	155507290	C	T	155507290	3	4	59	1	0	0	0	0	1	0	0	0	5830	922	32	1	1361	1	FGA	4	155507290	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2263055	155507290	35646986	153	16956										
PALLD	23022	broad.mit.edu	37	chr4	169433557	169433557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cactggaaaccccactcctcGagtcaggtatgaatttttgt	8	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:169433557G>A	uc011cjx.1	+	2	1113	c.902G>A	c.(901-903)CGA>CAA	p.R301Q	PALLD_uc003iru.2_Missense_Mutation_p.R301Q	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	301	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCCACTCCTCGAGTCAGGTAT	0.443									Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.013537	0	12	20										A	169433557	G	A	169433557	3	1	59	1	0	0	0	0	1	0	0	0	11407	1058	37	1	904	1	PALLD	4	169433557	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	13926267	169433557	21720719	154	16957										
HMGB2	3148	broad.mit.edu	37	chr4	174254744	174254744	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcttcccggcaggtctgcacGaagaaggcgtacgaggacat	13	11	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:174254744G>A	uc011ckc.1	-	1	177	c.57C>T	c.(55-57)TTC>TTT	p.F19F	HMGB2_uc003ita.3_Silent_p.F19F|HMGB2_uc003itb.2_Silent_p.F19F|HMGB2_uc003itc.2_Silent_p.F19F	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	19	HMG box 1.				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AGGTCTGCACGAAGAAGGCGT	0.582													0	0	0	0.013726	0	33	53										A	174254744	G	A	174254744	2	1	59	1	0	0	0	0	0	0	0	1	7226	1049	37	1		1	HMGB2	4	174254744	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4821187	174254744	16899532	155	16958										
FRG1	2483	broad.mit.edu	37	chr4	190884260	190884260	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttaaacaggagagccaaattGaaagccgacagatactgcaa	9	8	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:190884260G>A	uc003izs.2	+	9	944	c.753G>A	c.(751-753)TTG>TTA	p.L251L		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	251	Bipartite nuclear localization signal (Potential).				rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GAGCCAAATTGAAAGCCGACA	0.299													0	0	0	0.006214	0	8	29										A	190884260	G	A	190884260	2	1	59	1	0	0	0	0	0	0	0	1	6046	1281	45	1		1	FRG1	4	190884260	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	16629516	190884260	270016	156	16959										
TERT	7015	broad.mit.edu	37	chr5	1268641	1268641	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agaggaggcctcacccgtccCgccgaatccccgcaaacagc	10	18	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:1268641C>T	uc003jcb.1	-	9	2634	c.2576G>A	c.(2575-2577)CGG>CAG	p.R859Q	TERT_uc003jbz.1_Missense_Mutation_p.R55Q|TERT_uc003jca.1_Missense_Mutation_p.R847Q|TERT_uc003jcc.1_Missense_Mutation_p.R859Q|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	859	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCACCCGTCCCGCCGAATCCC	0.597									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				0	0	0	0.001168	0	5	49										T	1268641	C	T	1268641	3	4	59	1	0	0	0	0	1	0	0	0	15761	652	23	2	854	2	TERT	5	1268641	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		1268641	179646619	157	16960										
DNAH5	1767	broad.mit.edu	37	chr5	13823435	13823435	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccagaagaatatttggaaaGagatcttcaatcaaactcaa	6	7	4	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:13823435G>C	uc003jfd.2	-	40	6666	c.6624C>G	c.(6622-6624)CTC>CTG	p.L2208L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2208					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TATTTGGAAAGAGATCTTCAA	0.383									Kartagener_syndrome				0	0	0	0.010729	0	10	122										C	13823435	G	C	13823435	2	2	59	1	0	0	0	0	0	0	0	1	4604	929	33	1		1	DNAH5	5	13823435	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12554794	13823435	167091825	158	16961										
CDH18	1016	broad.mit.edu	37	chr5	19591215	19591215	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tctctttgtcagtggagattGagaatattcccatgccatca	8	9	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:19591215G>A	uc003jgc.2	-	6	1327	c.950C>T	c.(949-951)TCA>TTA	p.S317L	CDH18_uc003jgd.2_Missense_Mutation_p.S317L|CDH18_uc011cnm.1_Missense_Mutation_p.S317L	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	317	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGTGGAGATTGAGAATATTCC	0.408													0	0	0	0.008291	0	10	129										A	19591215	G	A	19591215	3	1	59	1	0	0	0	0	1	0	0	0	3103	1294	45	1	1450	1	CDH18	5	19591215	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5767780	19591215	161324045	159	16962										
HMGCS1	3157	broad.mit.edu	37	chr5	43298164	43298164	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttagcagagctactgctccaActccacctgtaggtctagca	8	13	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:43298164A>G	uc003jnr.3	-	4	728	c.521T>C	c.(520-522)GTT>GCT	p.V174A	HMGCS1_uc003jnq.3_Missense_Mutation_p.V174A	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	174					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						TACTGCTCCAACTCCACCTGT	0.398													0	0	0	0.007291	0	24	95										G	43298164	A	G	43298164	3	3	59	1	0	0	0	0	1	0	0	0	7232	43	2	5	1073	5	HMGCS1	5	43298164	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	23706949	43298164	137617096	160	16963										
MAN2A1	4124	broad.mit.edu	37	chr5	109191017	109191017	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gacattcatctggttaatttGagaacaatacagtcaaaggt	8	6	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:109191017G>C	uc003kou.1	+	20	4116	c.3153G>C	c.(3151-3153)TTG>TTC	p.L1051F		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	1051	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TGGTTAATTTGAGAACAATAC	0.338													0	0	0	0.00499	0	14	24										C	109191017	G	C	109191017	3	2	59	1	0	0	0	0	1	0	0	0	9214	1281	45	1	3231	1	MAN2A1	5	109191017	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	65892853	109191017	71724243	161	16964										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139781720	139781720	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccgggccagcgtcgggagtCggcagcagcggcggcggcgg	22	13	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:139781720C>T	uc003lfs.1	+	1	292	c.168C>T	c.(166-168)GTC>GTT	p.V56V	ANKHD1_uc003lfq.1_Silent_p.V56V|ANKHD1_uc003lfr.2_Silent_p.V56V|uc003lfn.2_5'Flank|ANKHD1_uc003lfp.2_Silent_p.V56V|ANKHD1_uc003lfo.2_Silent_p.V56V|ANKHD1_uc010jfk.2_Silent_p.V56V	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	56						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCGGGAGTcggcagcagcg	0.622													0	0	0	0.004672	0	3	6										T	139781720	C	T	139781720	2	4	59	1	0	0	0	0	0	0	0	1	629	871	31	1		1	ANKHD1-EIF4EBP3	5	139781720	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	30590703	139781720	41133540	162	16965										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139905682	139905682	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caaatgtgtttgggaaaaaaAgggccaatgtggtgacaact	12	5	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:139905682A>G	uc003lfs.1	+	26	4718	c.4594A>G	c.(4594-4596)AGG>GGG	p.R1532G	ANKHD1_uc003lfr.2_Missense_Mutation_p.R1532G|ANKHD1_uc003lfu.1_Missense_Mutation_p.R1012G|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R271G|ANKHD1_uc003lfw.2_Missense_Mutation_p.R170G|ANKHD1_uc010jfl.2_5'UTR|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1532						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGAAAAAAAGGGCCAATGT	0.423													0	0	0	0.004672	0	3	104										G	139905682	A	G	139905682	3	3	59	1	0	0	0	0	1	0	0	0	629	63	3	5	4696	5	ANKHD1-EIF4EBP3	5	139905682	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	123962	139905682	41009578	163	16966										
MGAT1	4245	broad.mit.edu	37	chr5	180219305	180219305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagcagcggataggtggcccGaaagtactcgaagaagtccg	14	10	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:180219305G>A	uc003mmg.3	-	2	1162	c.667C>T	c.(667-669)CGG>TGG	p.R223W	MGAT1_uc010jlf.2_Missense_Mutation_p.R223W|MGAT1_uc010jlg.2_Missense_Mutation_p.R223W|MGAT1_uc003mmh.3_Missense_Mutation_p.R223W|MGAT1_uc010jlh.2_Missense_Mutation_p.R223W|MGAT1_uc003mmi.3_Missense_Mutation_p.R223W	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	223	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGGTGGCCCGAAAGTACTCG	0.667													0	0	0	0.012319	0	22	36										A	180219305	G	A	180219305	3	1	59	1	0	0	0	0	1	0	0	0	9542	1057	37	1	674	1	MGAT1	5	180219305	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	40313623	180219305	695955	164	16967										
MGAT1	4245	broad.mit.edu	37	chr5	180219511	180219511	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcgtgaccgcgctgccgtagGaggcgatggcctgggccgtc	18	13	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:180219511G>C	uc003mmg.3	-	2	956	c.461C>G	c.(460-462)TCC>TGC	p.S154C	MGAT1_uc010jlf.2_Missense_Mutation_p.S154C|MGAT1_uc010jlg.2_Missense_Mutation_p.S154C|MGAT1_uc003mmh.3_Missense_Mutation_p.S154C|MGAT1_uc010jlh.2_Missense_Mutation_p.S154C|MGAT1_uc003mmi.3_Missense_Mutation_p.S154C	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	154	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGCCGTAGGAGGCGATGGC	0.662													0	0	0	0.004656	0	23	33										C	180219511	G	C	180219511	3	2	59	1	0	0	0	0	1	0	0	0	9542	1174	41	1	880	1	MGAT1	5	180219511	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	206	180219511	695749	165	16968										
DTNBP1	84062	broad.mit.edu	37	chr6	15627595	15627595	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagatttgctgtcatggattCtaagtctgcgattaaagctg	10	7	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:15627595C>T	uc003nbm.2	-	5	505	c.334G>A	c.(334-336)GAA>AAA	p.E112K	DTNBP1_uc003nbl.2_Missense_Mutation_p.E31K|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA|DTNBP1_uc003nbp.2_Missense_Mutation_p.E112K|DTNBP1_uc010jph.2_Missense_Mutation_p.E99K	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	112	Potential.				actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			GTCATGGATTCTAAGTCTGCG	0.453									Hermansky-Pudlak_syndrome				0	0	0	0.003163	0	14	55										T	15627595	C	T	15627595	3	4	59	1	0	0	0	0	1	0	0	0	4790	922	32	1	846	1	DTNBP1	6	15627595	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		15627595	155487472	166	16969										
KIF13A	63971	broad.mit.edu	37	chr6	17850667	17850667	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgttcgagacttatttccctCagacatcaatgactcaatat	5	11	3	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:17850667C>T	uc003ncg.3	-	8	709	c.604G>A	c.(604-606)GAG>AAG	p.E202K	KIF13A_uc003ncf.2_Missense_Mutation_p.E202K|KIF13A_uc003nch.3_Missense_Mutation_p.E202K|KIF13A_uc003nci.3_Missense_Mutation_p.E202K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	202	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTATTTCCCTCAGACATCAAT	0.413													0	0	0	0.001168	0	6	8										T	17850667	C	T	17850667	3	4	59	1	0	0	0	0	1	0	0	0	8274	835	29	1	4966	1	KIF13A	6	17850667	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2223072	17850667	153264400	167	16970										
E2F3	1871	broad.mit.edu	37	chr6	20490417	20490417	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agacttggcttcaaccaactCaggacatagcgattgctcag	9	11	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:20490417C>G	uc003nda.2	+	7	1481	c.1154C>G	c.(1153-1155)TCA>TGA	p.S385*		NM_001949	NP_001940	O00716	E2F3_HUMAN	E2F transcription factor 3	385					G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			TCAACCAACTCAGGACATAGC	0.398													0	0	0	0.007413	0	15	97										G	20490417	C	G	20490417	4	3	59	1	0	0	0	0	0	1	0	0	4868	838	29	1	1180	1	E2F3	6	20490417	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2639750	20490417	150624650	168	16971										
TDP2	51567	broad.mit.edu	37	chr6	24666972	24666972	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggaagcactgagccactgcgGcatcgcagcttgcgaccgag	14	13	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:24666972G>A	uc003nej.2	-	1	144	c.119C>T	c.(118-120)GCC>GTC	p.A40V	TDP2_uc003nei.2_5'Flank|TDP2_uc010jpu.1_Missense_Mutation_p.A40V|ACOT13_uc010jpv.2_5'Flank|ACOT13_uc003nek.2_5'Flank	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	40					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						AGCCACTGCGGCATCGCAGCT	0.632								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.001984	0	5	242										A	24666972	G	A	24666972	3	1	59	1	0	0	0	0	1	0	0	0	15726	1203	42	2	997	2	TDP2	6	24666972	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4176555	24666972	146448095	169	16972										
BTN3A3	10384	broad.mit.edu	37	chr6	26444194	26444194	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgtgctgacagctcagttttCtgtgcttggaccctctgggc	12	11	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:26444194C>G	uc003nhz.2	+	4	275	c.95C>G	c.(94-96)TCT>TGT	p.S32C	BTN3A3_uc003nia.2_5'UTR|BTN3A3_uc011dkn.1_5'UTR	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	32	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0						GCTCAGTTTTCTGTGCTTGGA	0.577													0	0	0	0.00499	0	15	44										G	26444194	C	G	26444194	3	3	59	1	0	0	0	0	1	0	0	0	1564	913	32	1	101	1	BTN3A3	6	26444194	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1777222	26444194	144670873	170	16973										
BTN3A3	10384	broad.mit.edu	37	chr6	26444498	26444498	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tatttccaagatggtgacttCtacgaaaaagccctggtgga	10	8	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:26444498C>G	uc003nhz.2	+	4	579	c.399C>G	c.(397-399)TTC>TTG	p.F133L	BTN3A3_uc003nia.2_Missense_Mutation_p.F91L|BTN3A3_uc011dkn.1_Missense_Mutation_p.F91L	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	133	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0						ATGGTGACTTCTACGAAAAAG	0.507													0	0	0	0.007835	0	37	97										G	26444498	C	G	26444498	3	3	59	1	0	0	0	0	1	0	0	0	1564	912	32	1	405	1	BTN3A3	6	26444498	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	304	26444498	144670569	171	16974										
BTN1A1	696	broad.mit.edu	37	chr6	26508197	26508197	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gagagactcctggaagaactCagtaagttctgtcttcttgt	10	8	4	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:26508197C>T	uc003nif.3	+	5	899	c.879C>T	c.(877-879)CTC>CTT	p.L293L		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	293	B30.2/SPRY.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						TGGAAGAACTCAGTAAGTTCT	0.383													0	0	0	0.014323	0	17	91										T	26508197	C	T	26508197	2	4	59	1	0	0	0	0	0	0	0	1	1559	840	29	1		1	BTN1A1	6	26508197	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	63699	26508197	144606870	172	16975										
NOTCH4	4855	broad.mit.edu	37	chr6	32164149	32164149	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccggcctggagaagcgagcgGgcggctcgggcgttgttcac	18	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:32164149G>A	uc003obb.2	-	29	5389	c.5250C>T	c.(5248-5250)GCC>GCT	p.A1750A	GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_Intron|NOTCH4_uc003oba.2_Silent_p.A410A|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_Silent_p.A159A	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1750	Cytoplasmic (Potential).|ANK 4.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GAAGCGAGCGGGCGGCTCGGG	0.632													0	0	0	0.01441	0	36	93										A	32164149	G	A	32164149	2	1	59	1	0	0	0	0	0	0	0	1	10551	1219	43	2		2	NOTCH4	6	32164149	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5655952	32164149	138950918	173	16976										
KIFC1	3833	broad.mit.edu	37	chr6	33372709	33372709	+	Frame_Shift_Del	DEL	G	G	-													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cggcaggagactgtggcccaGgcagccttactgactgagcg							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:33372709delG	uc003oef.3	+	7	1287	c.837delG	c.(835-837)CAGfs	p.Q279fs	KIFC1_uc011drf.1_Frame_Shift_Del_p.Q271fs	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	279	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CTGTGGCCCAGGCAGCCTTAC	0.587																		10	80	---	---								-	33372709	G	-	33372709	7	5	59	1	0	1	0	1	0	0	0	0	8312	991	35	0	863	0	KIFC1	6	33372709	Frame_Shift_Del	DEL	G	TCGA-DK-A3IN-01A-11D-A20D-08	1208560	33372709	137742358	174	16977										
CDKN1A	1026	broad.mit.edu	37	chr6	36652121	36652122	+	Frame_Shift_Ins	INS	-	-	C													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agctctaccttcccacggggINSccccggcgaggccgggatga							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:36652121_36652122insC	uc003omm.3	+	2	365_366	c.243_244insC	c.(241-246)GGGCCCfs	p.G81fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.G115fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.G81fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.G81fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	81_82					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						TTCCCACGGGGCCCCGGCGAGG	0.653									Multiple_Endocrine_Neoplasia_type_1									8	23	---	---								C	36652122	-	C	36652121	7	5	59	1	0	1	1	0	0	0	0	0	3158	1190	42	0	245	0	CDKN1A	6	36652121	Frame_Shift_Ins	INS	-	TCGA-DK-A3IN-01A-11D-A20D-08	3279412	36652121	134462946	175	16978										
TTBK1	84630	broad.mit.edu	37	chr6	43251283	43251283	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acctttgtgcacattgcggaGaaaacccacctcaacgtcat	7	13	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:43251283G>A	uc003ouq.1	+	14	3084	c.2805G>A	c.(2803-2805)GAG>GAA	p.E935E		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	935						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			ACATTGCGGAGAAAACCCACC	0.632													0	0	0	0.003755	0	31	73										A	43251283	G	A	43251283	2	1	59	1	0	0	0	0	0	0	0	1	16673	933	33	1		1	TTBK1	6	43251283	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6599162	43251283	127863784	176	16979										
TDRD6	221400	broad.mit.edu	37	chr6	46660831	46660831	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agggaaatgactatttctatGaaataataacagaagatgtg	9	3	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:46660831G>A	uc003oyj.2	+	1	4966	c.4966G>A	c.(4966-4968)GAA>AAA	p.E1656K	TDRD6_uc010jze.2_Missense_Mutation_p.E1650K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1656					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTATTTCTATGAAATAATAAC	0.363													0	0	0	0.001855	0	12	46										A	46660831	G	A	46660831	3	1	59	1	0	0	0	0	1	0	0	0	15731	1291	45	1	4968	1	TDRD6	6	46660831	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3409548	46660831	124454236	177	16980										
TDRD6	221400	broad.mit.edu	37	chr6	46660877	46660877	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aataacaatactagaaatcaGaagggatgtttgtgatatcc	8	5	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:46660877G>A	uc003oyj.2	+	1	5012	c.5012G>A	c.(5011-5013)AGA>AAA	p.R1671K	TDRD6_uc010jze.2_Missense_Mutation_p.R1665K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1671					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTAGAAATCAGAAGGGATGTT	0.303													0	0	0	0.013537	0	11	38										A	46660877	G	A	46660877	3	1	59	1	0	0	0	0	1	0	0	0	15731	942	33	1	5014	1	TDRD6	6	46660877	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	46	46660877	124454190	178	16981										
PKHD1	5314	broad.mit.edu	37	chr6	51889923	51889923	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtgtctggaaacattaccaGaacaagcatacccatttctt	6	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:51889923G>A	uc003pah.1	-	32	4961	c.4685C>T	c.(4684-4686)TCT>TTT	p.S1562F	PKHD1_uc003pai.2_Missense_Mutation_p.S1562F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1562	Extracellular (Potential).|IPT/TIG 10.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AACATTACCAGAACAAGCATA	0.428													0	0	0	0.004007	0	17	31										A	51889923	G	A	51889923	3	1	59	1	0	0	0	0	1	0	0	0	11971	942	33	1	7722	1	PKHD1	6	51889923	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5229046	51889923	119225144	179	16982										
ELOVL5	60481	broad.mit.edu	37	chr6	53138102	53138102	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaaccatagtaagagtacatGaggacgtggatgaagctatt	11	5	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:53138102G>A	uc003pbq.1	-	6	985	c.537C>T	c.(535-537)CTC>CTT	p.L179L	ELOVL5_uc003pbr.1_Silent_p.L179L|ELOVL5_uc011dwx.1_Silent_p.L206L|ELOVL5_uc003pbs.1_Intron|ELOVL5_uc003pbt.3_5'Flank	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	179	Helical; (Potential).			YFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQL LQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMISLIALFTN FYIQTYNKKGASRR -> SVCADNHPDQLRGHLAVHIPSWL VVFPDWIHDFPDCSLHKLLHSDLQQERGLPKERPPEGPPEW VHGCCEWTHQQLFTPGKQCEAKEAAEGLKSKN (in Ref. 4; BAD93035).	fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					AAGAGTACATGAGGACGTGGA	0.473													0	0	0	0.01441	0	50	101										A	53138102	G	A	53138102	2	1	59	1	0	0	0	0	0	0	0	1	5077	1277	45	1		1	ELOVL5	6	53138102	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1248179	53138102	117976965	180	16983										
SNX14	57231	broad.mit.edu	37	chr6	86253327	86253327	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atcgtctttgacttacttctTtgaatctcttctacaatgaa	4	9	4	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:86253327T>C	uc003pkr.2	-	13	1453	c.1260A>G	c.(1258-1260)CAA>CAG	p.Q420Q	SNX14_uc003pkp.2_Silent_p.Q283Q|SNX14_uc003pkq.2_Silent_p.Q35Q|SNX14_uc011dzg.1_Silent_p.Q368Q|SNX14_uc003pks.2_Silent_p.Q376Q|SNX14_uc003pkt.2_Silent_p.Q420Q	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	420	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ACTTACTTCTTTGAATCTCTT	0.318													0	0	0	0.004672	0	3	8										C	86253327	T	C	86253327	2	2	59	1	0	0	0	0	0	0	0	1	14885	1838	64	5		5	SNX14	6	86253327	Silent	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	33115225	86253327	84861740	181	16984										
C6orf203	51250	broad.mit.edu	37	chr6	107365503	107365503	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tacaaaggtgaactcaggctGaatgaggaaaaattatggaa	11	4	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:107365503G>A	uc003prq.2	+	3	591	c.510G>A	c.(508-510)CTG>CTA	p.L170L	C6orf203_uc011eaj.1_Silent_p.L175L|C6orf203_uc010kde.2_Silent_p.L170L	NM_016487	NP_057571	Q9P0P8	CF203_HUMAN	hypothetical protein LOC51250 isoform a	170											0	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		AACTCAGGCTGAATGAGGAAA	0.289													0	0	0	0.012213	0	28	53										A	107365503	G	A	107365503	2	1	59	1	0	0	0	0	0	0	0	1	2352	1277	45	1		1	C6orf203	6	107365503	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	21112176	107365503	63749564	182	16985										
PDSS2	57107	broad.mit.edu	37	chr6	107780313	107780313	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaggacgtggggtaccccacGatcttctccgcctctgacac	10	15	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:107780313G>A	uc003prt.2	-	1	467	c.177C>T	c.(175-177)ATC>ATT	p.I59I	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Silent_p.I59I|PDSS2_uc003pru.2_Silent_p.I59I|PDSS2_uc003prv.2_Silent_p.I59I	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	59					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		GGTACCCCACGATCTTCTCCG	0.637											OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	38										A	107780313	G	A	107780313	2	1	59	1	0	0	0	0	0	0	0	1	11694	1048	37	1		1	PDSS2	6	107780313	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	414810	107780313	63334754	183	16986										
MICAL1	64780	broad.mit.edu	37	chr6	109768352	109768352	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagcggaagcagctccggtgGaagaaatggccgttgacaca	14	10	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:109768352G>C	uc003ptj.2	-	16	2405	c.2151C>G	c.(2149-2151)TTC>TTG	p.F717L	MICAL1_uc003ptk.2_Missense_Mutation_p.F717L|MICAL1_uc010kdr.2_Missense_Mutation_p.F631L|MICAL1_uc011eaq.1_Missense_Mutation_p.F736L	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	717	LIM zinc-binding.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		AGCTCCGGTGGAAGAAATGGC	0.627													0	0	0	0.015359	0	30	66										C	109768352	G	C	109768352	3	2	59	1	0	0	0	0	1	0	0	0	9569	1165	41	1	1088	1	MICAL1	6	109768352	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1988039	109768352	61346715	184	16987										
MED23	9439	broad.mit.edu	37	chr6	131908944	131908944	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtgtgtgatgaatcgaagacGaagttttaaagctggtttta	12	3	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:131908944G>A	uc003qcs.1	-	29	4156	c.3982C>T	c.(3982-3984)CGT>TGT	p.R1328C	MED23_uc003qcq.2_Missense_Mutation_p.R1334C|MED23_uc003qcr.1_Missense_Mutation_p.R183C	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	1328					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AATCGAAGACGAAGTTTTAAA	0.403													0	0	0	0.004672	0	3	20										A	131908944	G	A	131908944	3	1	59	1	0	0	0	0	1	0	0	0	9441	1058	37	1	135	1	MED23	6	131908944	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	22140592	131908944	39206123	185	16988										
PPIL4	85313	broad.mit.edu	37	chr6	149854672	149854672	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcctcagctgatcttcctttGaaatcatcaatttcttcatc	3	12	6	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:149854672G>C	uc003qmo.1	-	7	630	c.600C>G	c.(598-600)TTC>TTG	p.F200L	PPIL4_uc010kic.2_Intron|PPIL4_uc003qmp.1_Missense_Mutation_p.F200L	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	200					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		ATCTTCCTTTGAAATCATCAA	0.323													0	0	0	0.001855	0	11	22										C	149854672	G	C	149854672	3	2	59	1	0	0	0	0	1	0	0	0	12329	1281	45	1	906	1	PPIL4	6	149854672	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	17945728	149854672	21260395	186	16989										
ZDHHC14	79683	broad.mit.edu	37	chr6	157803263	157803263	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttctacctgacgctcgtcctCatcctggtcactagcggact	8	15	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:157803263C>T	uc003qqt.2	+	1	707	c.210C>T	c.(208-210)CTC>CTT	p.L70L	ZDHHC14_uc003qqs.2_Silent_p.L70L	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	70	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CGCTCGTCCTCATCCTGGTCA	0.627													0	0	0	0.001855	0	12	59										T	157803263	C	T	157803263	2	4	59	1	0	0	0	0	0	0	0	1	17601	813	29	1		1	ZDHHC14	6	157803263	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	7948591	157803263	13311804	187	16990										
ZDHHC14	79683	broad.mit.edu	37	chr6	157963684	157963684	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctggcatcctgttcttctttGtgatggggaccctgctccgc	11	13	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:157963684G>T	uc003qqt.2	+	2	810	c.313G>T	c.(313-315)GTG>TTG	p.V105L	ZDHHC14_uc003qqs.2_Missense_Mutation_p.V105L|ZDHHC14_uc010kjm.1_5'UTR	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	105	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GTTCTTCTTTGTGATGGGGAC	0.607													1	0	7.53681e-25	0.00632	8.12234e-25	25	50										T	157963684	G	T	157963684	3	4	59	1	0	0	0	0	1	0	0	0	17601	1377	48	4	319	4	ZDHHC14	6	157963684	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	160421	157963684	13151383	188	16991										
TULP4	56995	broad.mit.edu	37	chr6	158924831	158924831	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctccagcccacacctggggaGagagaagaagaaagtgaaga	13	9	0	6			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:158924831G>A	uc003qrf.2	+	13	5493	c.4136G>A	c.(4135-4137)AGA>AAA	p.R1379K	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1379					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CACCTGGGGAGAGAGAAGAAG	0.493													0	0	0	0.004007	0	15	15										A	158924831	G	A	158924831	3	1	59	1	0	0	0	0	1	0	0	0	16773	942	33	1	4186	1	TULP4	6	158924831	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	961147	158924831	12190236	189	16992										
UNC93A	54346	broad.mit.edu	37	chr6	167709658	167709658	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggcaaagacatggtgaaccaGtattttggcatcttcttcct	9	9	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:167709658G>A	uc003qvq.2	+	3	583	c.408G>A	c.(406-408)CAG>CAA	p.Q136Q	UNC93A_uc003qvr.2_Silent_p.Q136Q	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	136						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGGTGAACCAGTATTTTGGCA	0.537													0	0	0	0.015359	0	28	116										A	167709658	G	A	167709658	2	1	59	1	0	0	0	0	0	0	0	1	16993	1020	36	2		2	UNC93A	6	167709658	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	8784827	167709658	3405409	190	16993										
DLL1	28514	broad.mit.edu	37	chr6	170592977	170592977	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgggcaggtgcaggagaagtCgttcacgccatcccggcagg	16	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:170592977C>T	uc003qxm.2	-	9	1860	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	464	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CAGGAGAAGTCGTTCACGCCA	0.697													0	0	0	0.00308	0	6	11										T	170592977	C	T	170592977	3	4	59	1	0	0	0	0	1	0	0	0	4566	884	31	1	793	1	DLL1	6	170592977	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2883319	170592977	522090	191	16994										
RNF216	54476	broad.mit.edu	37	chr7	5752476	5752476	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgaacacgtgcagctgccttCcatgcagctgagctccaact	9	15	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:5752476C>G	uc003soy.1	-	12	1871	c.1681G>C	c.(1681-1683)GAA>CAA	p.E561Q	RNF216_uc010ksz.1_Missense_Mutation_p.E183Q|RNF216_uc010kta.1_Missense_Mutation_p.E183Q|RNF216_uc011jwj.1_Missense_Mutation_p.E183Q|RNF216_uc003sox.1_Missense_Mutation_p.E618Q	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	561	RING-type 1.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CAGCTGCCTTCCATGCAGCTG	0.443													0	0	0	0.007413	0	17	15										G	5752476	C	G	5752476	3	3	59	1	0	0	0	0	1	0	0	0	13480	864	30	1	943	1	RNF216	7	5752476	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		5752476	153386187	192	16995										
DAGLB	221955	broad.mit.edu	37	chr7	6472552	6472552	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgttgctgatgaagcagggcGaggcccgccgcaatgtcgct	15	11	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:6472552G>A	uc003sqa.2	-	5	887	c.717C>T	c.(715-717)CTC>CTT	p.L239L	DAGLB_uc011jwt.1_Silent_p.L53L|DAGLB_uc011jwu.1_Missense_Mutation_p.S153L|DAGLB_uc003sqb.2_5'UTR|DAGLB_uc003sqc.2_Intron|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Silent_p.L198L|DAGLB_uc011jww.1_RNA	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	239	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GAAGCAGGGCGAGGCCCGCCG	0.607													0	0	0	0.003755	0	33	38										A	6472552	G	A	6472552	2	1	59	1	0	0	0	0	0	0	0	1	4227	1059	37	1		1	DAGLB	7	6472552	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	720076	6472552	152666111	193	16996										
HOXA3	3200	broad.mit.edu	37	chr7	27147998	27147998	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggcgggggcgactggggctCatacgggacgctgttgacca	19	10	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:27147998C>T	uc011jzl.1	-	3	1068	c.868G>A	c.(868-870)GAG>AAG	p.E290K	HOXA3_uc011jzk.1_Missense_Mutation_p.E132K|HOXA3_uc003syk.2_Missense_Mutation_p.E290K	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	290					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						GACTGGGGCTCATACGGGACG	0.701													0	0	0	0.004482	0	7	57										T	27147998	C	T	27147998	3	4	59	1	0	0	0	0	1	0	0	0	7293	835	29	1	467	1	HOXA3	7	27147998	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	20675446	27147998	131990665	194	16997										
ADCYAP1R1	117	broad.mit.edu	37	chr7	31121345	31121345	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caggagagtctgattttggtGacagtaactccttagatctc	10	8	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:31121345G>A	uc003tca.1	+	6	527	c.304G>A	c.(304-306)GAC>AAC	p.D102N	ADCYAP1R1_uc003tcb.1_Intron|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.D102N|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.D102N|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.D102N	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	102	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TGATTTTGGTGACAGTAACTC	0.493													0	0	0	0.006999	0	33	138										A	31121345	G	A	31121345	3	1	59	1	0	0	0	0	1	0	0	0	303	1290	45	1	322	1	ADCYAP1R1	7	31121345	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3973347	31121345	128017318	195	16998										
FKBP9	11328	broad.mit.edu	37	chr7	33044890	33044890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tatgttcaccaaccaggaccGgaatggagatgggaaggtca	13	8	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:33044890G>A	uc003tdh.2	+	10	1821	c.1640G>A	c.(1639-1641)CGG>CAG	p.R547Q	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.R600Q|FKBP9_uc011kam.1_Missense_Mutation_p.R315Q	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	547	EF-hand 2.|2 (Potential).				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			AACCAGGACCGGAATGGAGAT	0.502													0	0	0	0.010504	0	15	78										A	33044890	G	A	33044890	3	1	59	1	0	0	0	0	1	0	0	0	5915	1116	39	2	1678	2	FKBP9	7	33044890	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1923545	33044890	126093773	196	16999										
GLI3	2737	broad.mit.edu	37	chr7	42007389	42007389	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgagtccatgattggggtttCatcgatggcactgaggtctc	13	8	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:42007389C>T	uc011kbh.1	-	14	2327	c.2236G>A	c.(2236-2238)GAA>AAA	p.E746K	GLI3_uc011kbg.1_Missense_Mutation_p.E687K	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	746					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATTGGGGTTTCATCGATGGCA	0.532									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.005443	0	25	114										T	42007389	C	T	42007389	3	4	59	1	0	0	0	0	1	0	0	0	6439	835	29	1	2514	1	GLI3	7	42007389	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	8962499	42007389	117131274	197	17000										
C7orf44	55744	broad.mit.edu	37	chr7	43679188	43679188	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttctgggtcgtctctactccTttttcacttcatcaccgttt	5	13	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:43679188T>C	uc003tin.1	-	6	528	c.434A>G	c.(433-435)AAG>AGG	p.K145R	C7orf44_uc003til.2_RNA|C7orf44_uc003tii.2_RNA|C7orf44_uc003tij.2_RNA|C7orf44_uc010kxu.1_RNA|C7orf44_uc003tik.2_RNA|C7orf44_uc003tim.1_RNA|C7orf44_uc003tio.1_Missense_Mutation_p.K145R|C7orf44_uc003tiq.1_Missense_Mutation_p.K145R|C7orf44_uc003tip.1_Missense_Mutation_p.K145R	NM_018224	NP_060694	Q9GZY4	CG044_HUMAN	hypothetical protein LOC55744	145						integral to membrane				ovary(1)	1						TCTCTACTCCTTTTTCACTTC	0.517													0	0	0	0.004672	0	3	135										C	43679188	T	C	43679188	3	2	59	1	0	0	0	0	1	0	0	0	2394	1609	56	5	10	5	C7orf44	7	43679188	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	1671799	43679188	115459475	198	17001										
PURB	5814	broad.mit.edu	37	chr7	44924792	44924792	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aggaagcggcccttggcgttCtgcttcacatctaagtagaa	11	10	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:44924792C>G	uc003tme.2	-	1	169	c.156G>C	c.(154-156)CAG>CAC	p.Q52H		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	52	By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCTTGGCGTTCTGCTTCACAT	0.672													0	0	0	0.014758	0	5	26										G	44924792	C	G	44924792	3	3	59	1	0	0	0	0	1	0	0	0	12828	912	32	1	786	1	PURB	7	44924792	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1245604	44924792	114213871	199	17002										
ABCA13	154664	broad.mit.edu	37	chr7	48391850	48391850	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caaactgccaccccatgtctCatacacaatccggaccaatg	5	16	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:48391850C>T	uc003toq.2	+	31	10479	c.10454C>T	c.(10453-10455)TCA>TTA	p.S3485L	ABCA13_uc010kys.1_Missense_Mutation_p.S559L|ABCA13_uc003tos.1_Missense_Mutation_p.S311L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3485					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CCCCATGTCTCATACACAATC	0.443													0	0	0	0.00874	0	35	144										T	48391850	C	T	48391850	3	4	59	1	0	0	0	0	1	0	0	0	31	838	29	1	10405	1	ABCA13	7	48391850	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3467058	48391850	110746813	200	17003										
KIAA1324L	222223	broad.mit.edu	37	chr7	86569360	86569360	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttttttaccagcacaggcttGaccgccttagaacccataag	7	12	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:86569360G>C	uc011kha.1	-	6	998	c.813C>G	c.(811-813)GTC>GTG	p.V271V	KIAA1324L_uc003uif.1_Silent_p.V31V|KIAA1324L_uc011kgz.1_Silent_p.V157V|KIAA1324L_uc003uie.2_Silent_p.V104V	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	271	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GCACAGGCTTGACCGCCTTAG	0.368													0	0	0	0.012319	0	18	77										C	86569360	G	C	86569360	2	2	59	1	0	0	0	0	0	0	0	1	8224	1277	45	1		1	KIAA1324L	7	86569360	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	38177510	86569360	72569303	201	17004										
ADAM22	53616	broad.mit.edu	37	chr7	87563851	87563851	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggggacctgccctccggcgcGctgcggccaggcaggtaagt	17	14	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:87563851G>A	uc003ujn.2	+	1	150	c.71G>A	c.(70-72)CGC>CAC	p.R24H	ADAM22_uc003uji.1_Missense_Mutation_p.R24H|ADAM22_uc003ujj.1_Missense_Mutation_p.R24H|ADAM22_uc003ujk.1_Missense_Mutation_p.R24H|ADAM22_uc003ujl.1_Missense_Mutation_p.R24H|ADAM22_uc003ujm.2_Missense_Mutation_p.R24H|ADAM22_uc003ujo.2_Missense_Mutation_p.R24H|ADAM22_uc003ujp.1_5'Flank	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	24					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CCTCCGGCGCGCTGCGGCCAG	0.647													0	0	0	0.009096	0	3	16										A	87563851	G	A	87563851	3	1	59	1	0	0	0	0	1	0	0	0	244	1087	38	2	73	2	ADAM22	7	87563851	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	994491	87563851	71574812	202	17005										
ANKIB1	54467	broad.mit.edu	37	chr7	92027682	92027682	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttctttaccttccaggctgGactctgtccccagaaataca	6	14	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:92027682G>C	uc003ulw.2	+	20	3065	c.2689G>C	c.(2689-2691)GAC>CAC	p.D897H	ANKIB1_uc010lew.1_Missense_Mutation_p.D166H	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	897							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTCCAGGCTGGACTCTGTCCC	0.507													0	0	0	0.004672	0	3	12										C	92027682	G	C	92027682	3	2	59	1	0	0	0	0	1	0	0	0	630	1174	41	1	2763	1	ANKIB1	7	92027682	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4463831	92027682	67110981	203	17006										
COL1A2	1278	broad.mit.edu	37	chr7	94057029	94057029	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atggagacttctacagggctGaccagcctcgctcagcacct	10	14	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:94057029G>C	uc003ung.1	+	49	3829	c.3358G>C	c.(3358-3360)GAC>CAC	p.D1120H	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1120					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTACAGGGCTGACCAGCCTCG	0.547										HNSCC(75;0.22)			0	0	0	0.014323	0	23	69										C	94057029	G	C	94057029	3	2	59	1	0	0	0	0	1	0	0	0	3678	1290	45	1	3552	1	COL1A2	7	94057029	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2029347	94057029	65081634	204	17007										
COL1A2	1278	broad.mit.edu	37	chr7	94058695	94058695	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atgatgttgaacttgttgctGagggcaacagcaggttcact	12	7	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:94058695G>A	uc003ung.1	+	51	4378	c.3907G>A	c.(3907-3909)GAG>AAG	p.E1303K	COL1A2_uc011kib.1_Missense_Mutation_p.E155K	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1303	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	ACTTGTTGCTGAGGGCAACAG	0.458										HNSCC(75;0.22)			0	0	0	0.00499	0	14	50										A	94058695	G	A	94058695	3	1	59	1	0	0	0	0	1	0	0	0	3678	1291	45	1	4109	1	COL1A2	7	94058695	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1666	94058695	65079968	205	17008										
NPTX2	4885	broad.mit.edu	37	chr7	98256482	98256482	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cattgctgctcacaggttgcGcagctgcccctgtttgtcag	11	13	2	0	rs145736632	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:98256482G>T	uc003upl.2	+	4	1071	c.894G>T	c.(892-894)GCG>GCT	p.A298A		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	298	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CACAGGTTGCGCAGCTGCCCC	0.632													1	0	7.87624e-14	0.016522	8.40443e-14	22	32										T	98256482	G	T	98256482	2	4	59	1	0	0	0	0	0	0	0	1	10603	1074	38	4		4	NPTX2	7	98256482	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4197787	98256482	60882181	206	17009										
CYP3A4	1576	broad.mit.edu	37	chr7	99364768	99364768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttttaccttttgtgtatcttCgaggcgactttctttcatcc	6	10	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:99364768C>T	uc003urv.1	-	8	888	c.784G>A	c.(784-786)GAA>AAA	p.E262K	CYP3A4_uc003urw.1_Missense_Mutation_p.E261K|CYP3A4_uc011kiz.1_Missense_Mutation_p.E221K|CYP3A4_uc011kja.1_Missense_Mutation_p.E213K|CYP3A4_uc011kjb.1_Missense_Mutation_p.E112K	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	262					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TGTGTATCTTCGAGGCGACTT	0.308													0	0	0	0.008871	0	16	35										T	99364768	C	T	99364768	3	4	59	1	0	0	0	0	1	0	0	0	4178	893	31	1	751	1	CYP3A4	7	99364768	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1108286	99364768	59773895	207	17010										
MBLAC1	255374	broad.mit.edu	37	chr7	99725743	99725743	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcgagtgttaagggaagcctCgcagcccgagacggagggtg	17	9	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:99725743C>T	uc003utp.2	+	2	1124	c.725C>T	c.(724-726)TCG>TTG	p.S242L		NM_203397	NP_981942	A4D2B0	MBLC1_HUMAN	metallo-beta-lactamase domain containing 1	242							hydrolase activity|metal ion binding			breast(1)	1						AGGGAAGCCTCGCAGCCCGAG	0.677													0	0	0	0.009096	0	3	10										T	99725743	C	T	99725743	3	4	59	1	0	0	0	0	1	0	0	0	9351	893	31	1	727	1	MBLAC1	7	99725743	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	360975	99725743	59412920	208	17011										
PIK3CG	5294	broad.mit.edu	37	chr7	106545575	106545575	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acatctgtgttaaggcttatCtagcccttcgtcatcacaca	6	12	4	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:106545575C>G	uc003vdv.3	+	11	3137	c.3052C>G	c.(3052-3054)CTA>GTA	p.L1018V	PIK3CG_uc003vdu.2_Missense_Mutation_p.L1018V|PIK3CG_uc003vdw.2_Missense_Mutation_p.L1018V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	1018	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TAAGGCTTATCTAGCCCTTCG	0.398													0	0	0	0.01441	0	41	136										G	106545575	C	G	106545575	3	3	59	1	0	0	0	0	1	0	0	0	11916	912	32	1	3090	1	PIK3CG	7	106545575	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6819832	106545575	52593088	209	17012										
GIMAP8	155038	broad.mit.edu	37	chr7	150174615	150174615	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggaagacttcatgaagaactCagataacaaagcccttcggc	9	10	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:150174615C>T	uc003whj.2	+	5	2075	c.1745C>T	c.(1744-1746)TCA>TTA	p.S582L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	582						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGAAGAACTCAGATAACAAA	0.483													0	0	0	0.009535	0	27	85										T	150174615	C	T	150174615	3	4	59	1	0	0	0	0	1	0	0	0	6385	838	29	1	1759	1	GIMAP8	7	150174615	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	43629040	150174615	8964048	210	17013										
NUB1	51667	broad.mit.edu	37	chr7	151073831	151073831	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acaacggaggaagcctgcctCccgagctgccgctgtcgcca	12	16	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:151073831C>A	uc003wjx.2	+	14	1680	c.1675C>A	c.(1675-1677)CCC>ACC	p.P559T	NUB1_uc003wjw.2_Missense_Mutation_p.P521T|NUB1_uc010lqc.2_RNA	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	535					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		AAGCCTGCCTCCCGAGCTGCC	0.627													1	0	0.00909568	0.009096	0.00930201	4	7										A	151073831	C	A	151073831	3	1	59	1	0	0	0	0	1	0	0	0	10714	855	30	3	1611	3	NUB1	7	151073831	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	899216	151073831	8064832	211	17014										
ARHGEF10	9639	broad.mit.edu	37	chr8	1893769	1893769	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctttttcacacggaaactctCaagcacctgcaggacatcaa	6	13	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:1893769C>G	uc003wpr.2	+	27	3523	c.3345C>G	c.(3343-3345)CTC>CTG	p.L1115L	ARHGEF10_uc003wps.2_Silent_p.L1077L|ARHGEF10_uc010lre.2_Silent_p.L766L	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1140					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CGGAAACTCTCAAGCACCTGC	0.617													0	0	0	0.008871	0	18	38										G	1893769	C	G	1893769	2	3	59	1	0	0	0	0	0	0	0	1	894	813	29	1		1	ARHGEF10	8	1893769	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		1893769	144470253	212	17015										
MFHAS1	9258	broad.mit.edu	37	chr8	8750149	8750149	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agctggttgtggctgaggttGagcttccgcagctccctcag	14	11	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:8750149G>A	uc003wsj.1	-	1	983	c.420C>T	c.(418-420)CTC>CTT	p.L140L		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	140	LRR 4.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GGCTGAGGTTGAGCTTCCGCA	0.692													0	0	0	0.014758	0	4	4										A	8750149	G	A	8750149	2	1	59	1	0	0	0	0	0	0	0	1	9521	1277	45	1		1	MFHAS1	8	8750149	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6856380	8750149	137613873	213	17016										
TNKS	8658	broad.mit.edu	37	chr8	9413865	9413865	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttcttccccgacttcttcctCatcttcctctccatcctccc	1	21	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:9413865C>T	uc003wss.2	+	1	421	c.416C>T	c.(415-417)TCA>TTA	p.S139L	TNKS_uc011kwv.1_Missense_Mutation_p.S139L|uc003wsr.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	139	Poly-Ser.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		ACTTCTTCCTCATCTTCCTCT	0.632													0	0	0	0.01441	0	50	86										T	9413865	C	T	9413865	3	4	59	1	0	0	0	0	1	0	0	0	16316	838	29	1	418	1	TNKS	8	9413865	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	663716	9413865	136950157	214	17017										
WRN	7486	broad.mit.edu	37	chr8	31015039	31015039	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gttatccgaaaccctcccgtCaactcaggtgagaggcatgg	11	12	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:31015039C>T	uc003xio.3	+	33	4763	c.3975C>T	c.(3973-3975)GTC>GTT	p.V1325V	WRN_uc010lvk.2_Silent_p.V792V	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1325					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ACCCTCCCGTCAACTCAGGTG	0.478			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	0.013537	0	11	13										T	31015039	C	T	31015039	2	4	59	1	0	0	0	0	0	0	0	1	17399	813	29	1		1	WRN	8	31015039	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	21601174	31015039	115348983	215	17018										
RAB11FIP1	80223	broad.mit.edu	37	chr8	37732208	37732208	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttctcagatcttctcacaaGgtcttcagcaggccccgatg	8	13	5	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:37732208G>A	uc003xkm.1	-	3	1491	c.1447C>T	c.(1447-1449)CTT>TTT	p.L483F	RAB11FIP1_uc010lvz.1_Missense_Mutation_p.L331F|RAB11FIP1_uc003xkn.1_Missense_Mutation_p.L483F|RAB11FIP1_uc003xkl.1_5'Flank|RAB11FIP1_uc003xko.1_5'Flank|RAB11FIP1_uc003xkp.1_Missense_Mutation_p.L331F	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	483					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTTCTCACAAGGTCTTCAGCA	0.552													0	0	0	0.001168	0	6	158										A	37732208	G	A	37732208	3	1	59	1	0	0	0	0	1	0	0	0	12893	1000	35	2	2420	2	RAB11FIP1	8	37732208	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6717169	37732208	108631814	216	17019										
SGK196	84197	broad.mit.edu	37	chr8	42978000	42978000	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttagagatgccatgatgtctCaggcaagagagatgctgtga	13	6	1	5			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:42978000C>A	uc003xpw.2	+	5	1292	c.1033C>A	c.(1033-1035)CAG>AAG	p.Q345K		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	345	Protein kinase.					integral to membrane	ATP binding|protein kinase activity				0						CATGATGTCTCAGGCAAGAGA	0.493													1	0	2.0833e-19	0.01441	2.2274e-19	46	53										A	42978000	C	A	42978000	3	1	59	1	0	0	0	0	1	0	0	0	14208	827	29	3	1039	3	SGK196	8	42978000	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5245792	42978000	103386022	217	17020										
MCM4	4173	broad.mit.edu	37	chr8	48874078	48874078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgttttgtgtgacacaagctCggagtgaggatgccaggtca	14	7	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:48874078C>T	uc003xqk.1	+	3	168	c.73C>T	c.(73-75)CGG>TGG	p.R25W	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.R25W|MCM4_uc011ldi.1_Missense_Mutation_p.R25W|MCM4_uc010lxw.1_RNA	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	25					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GACACAAGCTCGGAGTGAGGA	0.547													0	0	0	0.003163	0	12	53										T	48874078	C	T	48874078	3	4	59	1	0	0	0	0	1	0	0	0	9389	875	31	1	79	1	MCM4	8	48874078	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5896078	48874078	97489944	218	17021										
RP1	6101	broad.mit.edu	37	chr8	55538439	55538439	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaatgaaaagaagattttgtCatctgttgccagcaaaaaga	8	5	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:55538439C>T	uc003xsd.1	+	4	2145	c.1997C>T	c.(1996-1998)TCA>TTA	p.S666L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	666					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGATTTTGTCATCTGTTGCC	0.348													0	0	0	0.008291	0	10	23										T	55538439	C	T	55538439	3	4	59	1	0	0	0	0	1	0	0	0	13532	838	29	1	2007	1	RP1	8	55538439	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6664361	55538439	90825583	219	17022										
LYN	4067	broad.mit.edu	37	chr8	56866484	56866484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agatgcctgggagatcccccGggagtccatcaagttggtga	14	10	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:56866484G>A	uc003xsk.3	+	8	1013	c.731G>A	c.(730-732)CGG>CAG	p.R244Q	LYN_uc003xsl.3_Missense_Mutation_p.R223Q	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	244					erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GAGATCCCCCGGGAGTCCATC	0.527													0	0	0	0.014323	0	18	72										A	56866484	G	A	56866484	3	1	59	1	0	0	0	0	1	0	0	0	9107	1116	39	2	757	2	LYN	8	56866484	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1328045	56866484	89497538	220	17023										
SGK3	23678	broad.mit.edu	37	chr8	67748054	67748054	+	Frame_Shift_Del	DEL	G	G	-													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tatgctgtcaaagtgttacaGaaaaaaatagttctcaacag							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:67748054delG	uc003xwr.2	+	9	881	c.582delG	c.(580-582)CAGfs	p.Q194fs	SGK3_uc003xwp.2_Frame_Shift_Del_p.Q188fs|SGK3_uc003xwt.2_Frame_Shift_Del_p.Q194fs|SGK3_uc003xwu.2_Frame_Shift_Del_p.Q194fs	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	194	Protein kinase.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AAGTGTTACAGAAAAAAATAG	0.289																		19	48	---	---								-	67748054	G	-	67748054	7	5	59	1	0	1	0	1	0	0	0	0	14212	933	33	0	612	0	SGK3	8	67748054	Frame_Shift_Del	DEL	G	TCGA-DK-A3IN-01A-11D-A20D-08	10881570	67748054	78615968	221	17024										
NECAB1	64168	broad.mit.edu	37	chr8	91962060	91962060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctatacagaagctttcaaatGaatctcgctacatgatctat	5	9	3	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:91962060G>C	uc011lgg.1	+	11	1080	c.886G>C	c.(886-888)GAA>CAA	p.E296Q	NECAB1_uc003yer.2_Missense_Mutation_p.E45Q	NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	296	ABM.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GCTTTCAAATGAATCTCGCTA	0.353													0	0	0	0.009096	0	4	13										C	91962060	G	C	91962060	3	2	59	1	0	0	0	0	1	0	0	0	10304	1291	45	1	928	1	NECAB1	8	91962060	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	24214006	91962060	54401962	222	17025										
INTS8	55656	broad.mit.edu	37	chr8	95850811	95850811	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aacagttgactccatatagtCaagtccatatttgtttgaga	7	7	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:95850811C>G	uc003yhb.2	+	8	1108	c.982C>G	c.(982-984)CAA>GAA	p.Q328E	INTS8_uc003yha.1_Missense_Mutation_p.Q328E|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.Q155E	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	328	TPR 2.				snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TCCATATAGTCAAGTCCATAT	0.289													0	0	0	0.005524	0	34	90										G	95850811	C	G	95850811	3	3	59	1	0	0	0	0	1	0	0	0	7784	827	29	1	1012	1	INTS8	8	95850811	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3888751	95850811	50513211	223	17026										
INTS8	55656	broad.mit.edu	37	chr8	95885644	95885644	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcttcactattacctccaggCaggagctgtgtgttctgact	9	11	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:95885644C>T	uc003yhb.2	+	22	2702	c.2576C>T	c.(2575-2577)GCA>GTA	p.A859V	INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.A686V	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	859	TPR 4.				snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TACCTCCAGGCAGGAGCTGTG	0.448													0	0	0	0.01441	0	97	251										T	95885644	C	T	95885644	3	4	59	1	0	0	0	0	1	0	0	0	7784	710	25	2	2662	2	INTS8	8	95885644	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	34833	95885644	50478378	224	17027										
RNF19A	25897	broad.mit.edu	37	chr8	101270981	101270981	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaccacagaaatgctacactGatgtggggaattttccagac	9	9	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:101270981G>A	uc003yjj.1	-	11	2637	c.2320C>T	c.(2320-2322)CAG>TAG	p.Q774*	RNF19A_uc003yjk.1_Nonsense_Mutation_p.Q774*	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	774	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			ATGCTACACTGATGTGGGGAA	0.398													0	0	0	0.007291	0	28	64										A	101270981	G	A	101270981	4	1	59	1	0	0	0	0	0	1	0	0	13470	1299	45	1	200	1	RNF19A	8	101270981	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5385337	101270981	45093041	225	17028										
RNF19A	25897	broad.mit.edu	37	chr8	101271310	101271310	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccctgctgttgcttctttgGaccacttggtggcactagat	10	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:101271310G>A	uc003yjj.1	-	11	2308	c.1991C>T	c.(1990-1992)TCC>TTC	p.S664F	RNF19A_uc003yjk.1_Missense_Mutation_p.S664F	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	664	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TGCTTCTTTGGACCACTTGGT	0.473											OREG0018897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00623	0	38	101										A	101271310	G	A	101271310	3	1	59	1	0	0	0	0	1	0	0	0	13470	1174	41	1	529	1	RNF19A	8	101271310	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	329	101271310	45092712	226	17029										
PKHD1L1	93035	broad.mit.edu	37	chr8	110534432	110534432	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	taggtcagatgcagttatctGaactccaggaaattgctggt	11	7	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:110534432G>C	uc003yne.2	+	74	12153	c.12049G>C	c.(12049-12051)GAA>CAA	p.E4017Q		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4017	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCAGTTATCTGAACTCCAGGA	0.348										HNSCC(38;0.096)			0	0	0	0.00308	0	8	15										C	110534432	G	C	110534432	3	2	59	1	0	0	0	0	1	0	0	0	11972	1291	45	1	12343	1	PKHD1L1	8	110534432	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9263122	110534432	35829590	227	17030										
MTSS1	9788	broad.mit.edu	37	chr8	125579322	125579322	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgaagcctacctgttcacttGaggagggcagtttgtgaggg	15	7	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:125579322G>C	uc003yrk.2	-	8	1250	c.716C>G	c.(715-717)TCA>TGA	p.S239*	NDUFB9_uc011lim.1_Intron|MTSS1_uc011lin.1_5'Flank|MTSS1_uc011lio.1_Nonsense_Mutation_p.S129*|MTSS1_uc003yri.2_Nonsense_Mutation_p.S39*|MTSS1_uc003yrj.2_Nonsense_Mutation_p.S239*|MTSS1_uc003yrl.2_Nonsense_Mutation_p.S243*	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	239	IMD.|Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTGTTCACTTGAGGAGGGCAG	0.483													0	0	0	0.004672	0	3	56										C	125579322	G	C	125579322	4	2	59	1	0	0	0	0	0	1	0	0	9962	1294	45	1	1579	1	MTSS1	8	125579322	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	15044890	125579322	20784700	228	17031										
KIAA0196	9897	broad.mit.edu	37	chr8	126090994	126090994	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcccacctggttgtaaatatCatcagatctcagtcgaccaa	6	12	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:126090994C>G	uc003yrt.2	-	6	1026	c.697G>C	c.(697-699)GAT>CAT	p.D233H	KIAA0196_uc011lir.1_Missense_Mutation_p.D85H	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	233					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTGTAAATATCATCAGATCTC	0.398													0	0	0	0.016522	0	22	63										G	126090994	C	G	126090994	3	3	59	1	0	0	0	0	1	0	0	0	8161	826	29	1	2878	1	KIAA0196	8	126090994	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	511672	126090994	20273028	229	17032										
ZFAT	57623	broad.mit.edu	37	chr8	135524803	135524803	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcttcggcctctgtgatgtgGagatactgggtggagggctc	16	8	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:135524803G>C	uc003yup.2	-	14	3451	c.3276C>G	c.(3274-3276)CTC>CTG	p.L1092L	ZFAT_uc011ljj.1_Silent_p.L211L|ZFAT_uc003yun.2_Silent_p.L1080L|ZFAT_uc003yuo.2_Silent_p.L1080L|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.L1080L|ZFAT_uc010mej.2_Silent_p.L1030L	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1092					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTGTGATGTGGAGATACTGGG	0.522													0	0	0	0.005524	0	35	103										C	135524803	G	C	135524803	2	2	59	1	0	0	0	0	0	0	0	1	17629	1161	41	1		1	ZFAT	8	135524803	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9433809	135524803	10839219	230	17033										
FAM135B	51059	broad.mit.edu	37	chr8	139164734	139164734	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttcctcctgctcttctgtgtGagagtcctttagggaagacc	10	11	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:139164734G>A	uc003yuy.2	-	13	2155	c.1984C>T	c.(1984-1986)CAC>TAC	p.H662Y	FAM135B_uc003yux.2_Missense_Mutation_p.H563Y|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.H224Y|FAM135B_uc003yvb.2_Missense_Mutation_p.H224Y	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	662										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCTTCTGTGTGAGAGTCCTTT	0.502										HNSCC(54;0.14)			0	0	0	0.00632	0	24	63										A	139164734	G	A	139164734	3	1	59	1	0	0	0	0	1	0	0	0	5449	1290	45	1	2268	1	FAM135B	8	139164734	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3639931	139164734	7199288	231	17034										
FAM135B	51059	broad.mit.edu	37	chr8	139263175	139263175	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtcgaacatgaccgggacctGgtggtgcagaccattccggg	15	11	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:139263175G>T	uc003yuy.2	-	6	622	c.451C>A	c.(451-453)CAG>AAG	p.Q151K	FAM135B_uc003yux.2_Missense_Mutation_p.Q52K|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	151										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCGGGACCTGGTGGTGCAGA	0.587										HNSCC(54;0.14)			1	0	2.53126e-37	0.01441	2.74982e-37	52	189										T	139263175	G	T	139263175	3	4	59	1	0	0	0	0	1	0	0	0	5449	1357	47	4	3829	4	FAM135B	8	139263175	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	98441	139263175	7100847	232	17035										
BAI1	575	broad.mit.edu	37	chr8	143570748	143570748	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccgtgactgtgaaacccccGcctcgctccctgcgcacacc	8	20	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:143570748G>A	uc003ywm.2	+	15	2763	c.2580G>A	c.(2578-2580)CCG>CCA	p.P860P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	860	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGAAACCCCCGCCTCGCTCCC	0.602													0	0	0	0.004878	0	32	144										A	143570748	G	A	143570748	2	1	59	1	0	0	0	0	0	0	0	1	1298	1074	38	2		2	BAI1	8	143570748	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4307573	143570748	2793274	233	17036										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18777151	18777151	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggcccggcccttgagcccgaGaagtgaggaagaggtgcttg	17	10	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:18777151G>A	uc003zne.3	+	19	3051	c.2924G>A	c.(2923-2925)AGA>AAA	p.R975K		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	975						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TTGAGCCCGAGAAGTGAGGAA	0.652													0	0	0	0.001168	0	5	40										A	18777151	G	A	18777151	3	1	59	1	0	0	0	0	1	0	0	0	274	942	33	1	3002	1	ADAMTSL1	9	18777151	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		18777151	122436280	234	17037										
ELAVL2	1993	broad.mit.edu	37	chr9	23701419	23701419	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctagcggtcctggataccttCtgtttggagactggtacagc	12	10	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:23701419C>T	uc003zpu.2	-	5	946	c.671G>A	c.(670-672)AGA>AAA	p.R224K	ELAVL2_uc003zps.2_Missense_Mutation_p.R224K|ELAVL2_uc003zpt.2_Missense_Mutation_p.R224K|ELAVL2_uc003zpv.2_Missense_Mutation_p.R224K|ELAVL2_uc003zpw.2_Missense_Mutation_p.R224K	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	224					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGGATACCTTCTGTTTGGAGA	0.488													0	0	0	0.004656	0	23	153										T	23701419	C	T	23701419	3	4	59	1	0	0	0	0	1	0	0	0	5050	913	32	1	420	1	ELAVL2	9	23701419	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4924268	23701419	117512012	235	17038										
NDUFB6	4712	broad.mit.edu	37	chr9	32553939	32553939	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccagtctccagaattgtatCaccctaggaaaacaaagata	6	10	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:32553939C>T	uc003zre.1	-	4	446	c.322G>A	c.(322-324)GAT>AAT	p.D108N	TOPORS_uc003zrb.2_5'Flank|TOPORS_uc003zrc.2_5'Flank|NDUFB6_uc003zrf.1_Missense_Mutation_p.D93N	NM_002493	NP_002484	O95139	NDUB6_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	108					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00199)	NADH(DB00157)	AGAATTGTATCACCCTAGGAA	0.239													0	0	0	0.01441	0	48	64										T	32553939	C	T	32553939	3	4	59	1	0	0	0	0	1	0	0	0	10285	826	29	1	68	1	NDUFB6	9	32553939	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	8852520	32553939	108659492	236	17039										
KIAA1045	23349	broad.mit.edu	37	chr9	34971383	34971383	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctttcaaggatgggctgcggGacaggccttccatccgacgc	13	13	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:34971383G>C	uc003zvq.2	+	2	266	c.88G>C	c.(88-90)GAC>CAC	p.D30H	KIAA1045_uc003zvr.2_Missense_Mutation_p.D30H	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	30							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			TGGGCTGCGGGACAGGCCTTC	0.617													0	0	0	0.010729	0	8	87										C	34971383	G	C	34971383	3	2	59	1	0	0	0	0	1	0	0	0	8207	1174	41	1	90	1	KIAA1045	9	34971383	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2417444	34971383	106242048	237	17040										
KIAA1045	23349	broad.mit.edu	37	chr9	34971486	34971486	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggagaaggaagcagaagcagGaacctcggtggtccaggaag	17	7	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:34971486G>A	uc003zvq.2	+	2	369	c.191G>A	c.(190-192)GGA>GAA	p.G64E	KIAA1045_uc003zvr.2_Missense_Mutation_p.G64E	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	64							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			GCAGAAGCAGGAACCTCGGTG	0.652													0	0	0	0.008291	0	10	70										A	34971486	G	A	34971486	3	1	59	1	0	0	0	0	1	0	0	0	8207	1174	41	1	193	1	KIAA1045	9	34971486	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	103	34971486	106241945	238	17041										
KIAA1045	23349	broad.mit.edu	37	chr9	34972478	34972478	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccaaggagacagtgcagcgGaggtgacggagatggcccac	16	10	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:34972478G>A	uc003zvq.2	+	3	692	c.514G>A	c.(514-516)GAG>AAG	p.E172K	KIAA1045_uc003zvr.2_Missense_Mutation_p.E172K	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	172	PHD-type.						calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			CAGTGCAGCGGAGGTGACGGA	0.597													0	0	0	0.007413	0	14	96										A	34972478	G	A	34972478	3	1	59	1	0	0	0	0	1	0	0	0	8207	1175	41	1	520	1	KIAA1045	9	34972478	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	992	34972478	106240953	239	17042										
RUSC2	9853	broad.mit.edu	37	chr9	35546546	35546546	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtcccccaaagctgactggaGagaccctcatcgttcatcac	8	15	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:35546546G>C	uc003zww.2	+	2	283	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E10Q	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	10						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCTGACTGGAGAGACCCTCAT	0.562													0	0	0	0.01441	0	68	87										C	35546546	G	C	35546546	3	2	59	1	0	0	0	0	1	0	0	0	13751	943	33	1	30	1	RUSC2	9	35546546	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	574068	35546546	105666885	240	17043										
RECK	8434	broad.mit.edu	37	chr9	36118870	36118870	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tatggggactgccaggccgtCggagtcctctcagagcacag	14	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:36118870C>T	uc003zyv.2	+	18	2456	c.2370C>T	c.(2368-2370)GTC>GTT	p.V790V	RECK_uc003zyw.2_Silent_p.V662V|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	790						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GCCAGGCCGTCGGAGTCCTCT	0.602													0	0	0	0.001855	0	13	72										T	36118870	C	T	36118870	2	4	59	1	0	0	0	0	0	0	0	1	13200	871	31	1		1	RECK	9	36118870	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	572324	36118870	105094561	241	17044										
FRMPD1	22844	broad.mit.edu	37	chr9	37746482	37746482	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaatggaccagtcccccgaaGagatgcagggggccgtgcgt	16	11	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:37746482G>C	uc004aag.1	+	16	4497	c.4453G>C	c.(4453-4455)GAG>CAG	p.E1485Q	FRMPD1_uc004aah.1_Missense_Mutation_p.E1485Q	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1485						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GTCCCCCGAAGAGATGCAGGG	0.637													0	0	0	0.012319	0	18	24										C	37746482	G	C	37746482	3	2	59	1	0	0	0	0	1	0	0	0	6057	943	33	1	4511	1	FRMPD1	9	37746482	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1627612	37746482	103466949	242	17045										
TMC1	117531	broad.mit.edu	37	chr9	75366836	75366836	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tatggagtcaatatggttctCtttatcctgacatttagcct	7	8	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:75366836C>T	uc004aiz.1	+	11	1146	c.606C>T	c.(604-606)CTC>CTT	p.L202L	TMC1_uc010moz.1_Silent_p.L160L|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Silent_p.L56L|TMC1_uc010mpa.1_Silent_p.L56L	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	202	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						ATATGGTTCTCTTTATCCTGA	0.373													0	0	0	0.01441	0	59	82										T	75366836	C	T	75366836	2	4	59	1	0	0	0	0	0	0	0	1	15981	900	32	1		1	TMC1	9	75366836	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	37620354	75366836	65846595	243	17046										
TRPM6	140803	broad.mit.edu	37	chr9	77397292	77397292	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acctacttgaagaaagcaatCaacaggttcaccatgatgat	7	9	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:77397292C>G	uc004ajl.1	-	23	3433	c.3195G>C	c.(3193-3195)TTG>TTC	p.L1065F	TRPM6_uc004ajk.1_Missense_Mutation_p.L1060F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_3'UTR	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1065	Helical; (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						AGAAAGCAATCAACAGGTTCA	0.363													0	0	0	0.008361	0	26	42										G	77397292	C	G	77397292	3	3	59	1	0	0	0	0	1	0	0	0	16587	825	29	1	2941	1	TRPM6	9	77397292	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2030456	77397292	63816139	244	17047										
PRUNE2	158471	broad.mit.edu	37	chr9	79320827	79320827	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcaggtcccatgcaagcactGaggtgcttctcagtctcttg	10	12	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:79320827G>A	uc010mpk.2	-	8	6487	c.6363C>T	c.(6361-6363)CTC>CTT	p.L2121L	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2121					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TGCAAGCACTGAGGTGCTTCT	0.493													0	0	0	0.01441	0	55	80										A	79320827	G	A	79320827	2	1	59	1	0	0	0	0	0	0	0	1	12641	1277	45	1		1	PRUNE2	9	79320827	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1923535	79320827	61892604	245	17048										
HNRNPK	3190	broad.mit.edu	37	chr9	86587005	86587005	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	catgggaaatcccactgggcGtccgcgacggtcatcaaaca	11	13	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:86587005G>A	uc004ang.3	-	11	969	c.745C>T	c.(745-747)CGC>TGC	p.R249C	HNRNPK_uc011lsw.1_Missense_Mutation_p.R9C|HNRNPK_uc004and.3_Missense_Mutation_p.R9C|HNRNPK_uc004ank.3_Missense_Mutation_p.R249C|HNRNPK_uc004anf.3_Missense_Mutation_p.R249C|HNRNPK_uc004anh.3_Missense_Mutation_p.R225C|HNRNPK_uc011lsx.1_Missense_Mutation_p.R225C|HNRNPK_uc004ani.3_Missense_Mutation_p.R249C|HNRNPK_uc004anj.3_Missense_Mutation_p.R249C|HNRNPK_uc004ann.3_Missense_Mutation_p.R225C|HNRNPK_uc004anl.3_Missense_Mutation_p.R249C|HNRNPK_uc004anm.3_Missense_Mutation_p.R249C|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	249	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.|RNA-binding RGG-box.|2 X 6 AA approximate repeats.|2-1.|Necessary for interaction with DDX1.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						CCCACTGGGCGTCCGCGACGG	0.498													0	0	0	0.004878	0	35	43										A	86587005	G	A	86587005	3	1	59	1	0	0	0	0	1	0	0	0	7269	1145	40	2	712	2	HNRNPK	9	86587005	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7266178	86587005	54626426	246	17049										
CTSL1	1514	broad.mit.edu	37	chr9	90342571	90342571	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgggaattgcctcagctaCtctaacatttgatcacagtt	7	11	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:90342571C>G	uc004aph.2	+	2	403	c.53C>G	c.(52-54)ACT>AGT	p.T18S	CTSL1_uc004api.2_Missense_Mutation_p.T18S|CTSL1_uc004apj.2_Intron|CTSL1_uc010mqh.2_5'UTR|CTSL1_uc004apk.2_Missense_Mutation_p.T18S|CTSL1_uc004apl.2_Missense_Mutation_p.T18S	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	18					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GCCTCAGCTACTCTAACATTT	0.428													0	0	0	0.009096	0	3	124										G	90342571	C	G	90342571	3	3	59	1	0	0	0	0	1	0	0	0	4038	565	20	4	55	4	CTSL1	9	90342571	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3755566	90342571	50870860	247	17050										
SHC3	53358	broad.mit.edu	37	chr9	91667005	91667005	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgtaaatattgcttaaaccgGagctcaaaggcttgtccgat	9	8	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:91667005G>C	uc004aqg.2	-	7	1216	c.909C>G	c.(907-909)CTC>CTG	p.L303L		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	303	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						GCTTAAACCGGAGCTCAAAGG	0.488													0	0	0	0.001984	0	7	73										C	91667005	G	C	91667005	2	2	59	1	0	0	0	0	0	0	0	1	14272	1161	41	1		1	SHC3	9	91667005	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1324434	91667005	49546426	248	17051										
PTCH1	5727	broad.mit.edu	37	chr9	98229398	98229398	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcctcccacgccgtcttacCctgaagccagtctctgaagt	8	16	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:98229398C>T	uc004avk.3	-	15	2748	c.2560G>A	c.(2560-2562)GGA>AGA	p.G854R	PTCH1_uc010mro.2_Missense_Mutation_p.G703R|PTCH1_uc010mrp.2_Missense_Mutation_p.G703R|PTCH1_uc010mrq.2_Missense_Mutation_p.G703R|PTCH1_uc004avl.3_Missense_Mutation_p.G703R|PTCH1_uc010mrr.2_Missense_Mutation_p.G788R|PTCH1_uc004avm.3_Missense_Mutation_p.G853R	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	854	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.G854*(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GCCGTCTTACCCTGAAGCCAG	0.458									Basal_Cell_Nevus_syndrome				0	0	0	0.014758	0	5	33										T	98229398	C	T	98229398	3	4	59	1	0	0	0	0	1	0	0	0	12730	637	22	2	1819	2	PTCH1	9	98229398	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6562393	98229398	42984033	249	17052										
ABCA1	19	broad.mit.edu	37	chr9	107554264	107554264	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgtcaacagcaggcttccGcttccttctatatatctgca	6	14	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:107554264G>A	uc004bcl.2	-	43	6086	c.5773C>T	c.(5773-5775)CGG>TGG	p.R1925W		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1925	ABC transporter 2.		R -> Q (in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane).		Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCAGGCTTCCGCTTCCTTCTA	0.438													0	0	0	0.006214	0	6	33										A	107554264	G	A	107554264	3	1	59	1	0	0	0	0	1	0	0	0	28	1086	38	2	1044	2	ABCA1	9	107554264	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9324866	107554264	33659167	250	17053										
PSMD5	5711	broad.mit.edu	37	chr9	123593680	123593680	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atcatccagcagattgctttCaaataaagcctccagtccag	6	12	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:123593680C>T	uc004bko.2	-	4	509	c.490G>A	c.(490-492)GAA>AAA	p.E164K	PSMD5_uc011lye.1_Intron	NM_005047	NP_005038	Q16401	PSMD5_HUMAN	proteasome 26S non-ATPase subunit 5	164					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding				0						AGATTGCTTTCAAATAAAGCC	0.368													0	0	0	0.004007	0	15	77										T	123593680	C	T	123593680	3	4	59	1	0	0	0	0	1	0	0	0	12701	835	29	1	1052	1	PSMD5	9	123593680	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	16039416	123593680	17619751	251	17054										
TOR2A	27433	broad.mit.edu	37	chr9	130496590	130496590	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagcctaccttgtagcgctcGatgtggctggggtgggggaa	17	9	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:130496590G>A	uc004brs.3	-	2	460	c.405C>T	c.(403-405)ATC>ATT	p.I135I	TOR2A_uc004brt.3_Silent_p.I135I|TOR2A_uc004brw.3_Silent_p.I135I|TOR2A_uc011maj.1_Intron|TOR2A_uc004bru.3_Intron|TOR2A_uc004brv.3_Intron|TOR2A_uc004brx.1_5'UTR	NM_001085347	NP_001078816	Q5JU69	TOR2A_HUMAN	torsin family 2, member A isoform a	135					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0						TGTAGCGCTCGATGTGGCTGG	0.642											OREG0019509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	16	36										A	130496590	G	A	130496590	2	1	59	1	0	0	0	0	0	0	0	1	16372	1048	37	1		1	TOR2A	9	130496590	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6902910	130496590	10716841	252	17055										
BAT2L1	84726	broad.mit.edu	37	chr9	134350698	134350698	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggagcaagcctttggggtcaGaggacaggcccggggccggg	20	10	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:134350698G>A	uc004can.3	+	15	3237	c.3182G>A	c.(3181-3183)AGA>AAA	p.R1061K	BAT2L1_uc010mzj.1_Missense_Mutation_p.R644K|BAT2L1_uc004cao.3_Missense_Mutation_p.R419K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1061							protein binding				0						TTTGGGGTCAGAGGACAGGCC	0.607													0	0	0	0.014758	0	5	22										A	134350698	G	A	134350698	3	1	59	1	0	0	0	0	1	0	0	0	1320	942	33	1	3240	1	BAT2L1	9	134350698	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3854108	134350698	6862733	253	17056										
LHX3	8022	broad.mit.edu	37	chr9	139090906	139090906	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttggccgtggcctcggcctCtgcgcggcgggcgagcggtg	19	14	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:139090906C>T	uc004cha.2	-	4	552	c.455_splice	c.e4-1	p.E152_splice	LHX3_uc004cgz.2_Splice_Site_p.E157_splice	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a						inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GCCTCGGCCTCTGCGCGGCGG	0.776													0	0	0	0.006214	0	8	7										T	139090906	C	T	139090906	5	4	59	1	0	0	0	0	0	0	1	0	8772	927	32	1	751	1	LHX3	9	139090906	Splice_Site	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4740208	139090906	2122525	254	17057										
MAN1B1	11253	broad.mit.edu	37	chr9	140002847	140002847	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggctgctgcacaggtcccctCgggtggctattcttccatca	11	14	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:140002847C>G	uc004cld.2	+	13	1939	c.1904C>G	c.(1903-1905)TCG>TGG	p.S635W	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.S308W|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	635	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CAGGTCCCCTCGGGTGGCTAT	0.612													0	0	0	0.008291	0	7	39										G	140002847	C	G	140002847	3	3	59	1	0	0	0	0	1	0	0	0	9212	893	31	1	1954	1	MAN1B1	9	140002847	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	911941	140002847	1210584	255	17058										
MAN1B1	11253	broad.mit.edu	37	chr9	140002885	140002885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcaacaatgtccaggatcctCagaagcccgagcctagggac	10	13	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:140002885C>G	uc004cld.2	+	13	1977	c.1942C>G	c.(1942-1944)CAG>GAG	p.Q648E	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.Q321E|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	648	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CCAGGATCCTCAGAAGCCCGA	0.597													0	0	0	0.010729	0	10	85										G	140002885	C	G	140002885	3	3	59	1	0	0	0	0	1	0	0	0	9212	827	29	1	1992	1	MAN1B1	9	140002885	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	38	140002885	1210546	256	17059										
OPTN	10133	broad.mit.edu	37	chr10	13164440	13164440	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctgagattgaaacccagacaGaggggagcacagagaaagag	14	7	0	6			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:13164440G>C	uc001ilu.1	+	9	1273	c.835G>C	c.(835-837)GAG>CAG	p.E279Q	OPTN_uc001ilv.1_Missense_Mutation_p.E279Q|OPTN_uc001ilw.1_Missense_Mutation_p.E279Q|OPTN_uc001ilx.1_Missense_Mutation_p.E279Q|OPTN_uc001ily.1_Missense_Mutation_p.E273Q|OPTN_uc010qbr.1_Missense_Mutation_p.E222Q|OPTN_uc001ilz.1_Missense_Mutation_p.E273Q	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	279	Potential.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						AACCCAGACAGAGGGGAGCAC	0.433													0	0	0	0.004007	0	14	63										C	13164440	G	C	13164440	3	2	59	1	0	0	0	0	1	0	0	0	10889	943	33	1	857	1	OPTN	10	13164440	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		13164440	122370307	257	17060										
CDNF	441549	broad.mit.edu	37	chr10	14870191	14870191	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caagcaaaaactgatcaattCtttctctatagtgtccagcg	6	10	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:14870191C>G	uc001inb.1	-	2	234	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CDNF_uc010qbv.1_Missense_Mutation_p.E66Q|CDNF_uc001inc.1_5'UTR	NM_001029954	NP_001025125	Q49AH0	CDNF_HUMAN	arginine-rich, mutated in early stage	66						extracellular region	growth factor activity				0						CTGATCAATTCTTTCTCTATA	0.363													0	0	0	0.010504	0	20	83										G	14870191	C	G	14870191	3	3	59	1	0	0	0	0	1	0	0	0	3168	922	32	1	379	1	CDNF	10	14870191	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1705751	14870191	120664556	258	17061										
ACBD7	414149	broad.mit.edu	37	chr10	15120550	15120550	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	taaattccgtatttttctatCagctcctttgctttagaaat	4	8	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:15120550C>G	uc001inv.2	-	4	294	c.246G>C	c.(244-246)CTG>CTC	p.L82L	ACBD7_uc010qby.1_Intron	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	82	ACB.						fatty-acyl-CoA binding				0						ATTTTTCTATCAGCTCCTTTG	0.398													0	0	0	0.005443	0	21	93										G	15120550	C	G	15120550	2	3	59	1	0	0	0	0	0	0	0	1	127	813	29	1		1	ACBD7	10	15120550	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	250359	15120550	120414197	259	17062										
C10orf140	387640	broad.mit.edu	37	chr10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCT													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atccgaggccccgctgccccINScctcctcctcctcttcctcc					rs138084841	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:21805466_21805467insCCT	uc009xkd.2	-	4	3538_3539	c.1285_1286insAGG	c.(1285-1287)GGG>GAGGGG	p.428_429insE	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	347_348	Ser-rich.|Glu-rich.					nucleus	nucleotide binding			ovary(1)	1						CCCGCTGCccccctcctcctcc	0.441																		3	3	---	---								CCT	21805467	-	CCT	21805466	7	5	59	1	0	1	1	0	0	0	0	0	1595	623	22	0	1444	0	C10orf140	10	21805466	In_Frame_Ins	INS	-	TCGA-DK-A3IN-01A-11D-A20D-08	6684916	21805466	113729281	260	17063										
LYZL2	119180	broad.mit.edu	37	chr10	30901786	30901786	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgtgtctctttaacaattttCttggcacagataatcgcatc	6	9	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:30901786C>G	uc001ivk.2	-	4	493	c.480G>C	c.(478-480)AAG>AAC	p.K160N		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	114					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				TAACAATTTTCTTGGCACAGA	0.443													0	0	0	0.00499	0	8	91										G	30901786	C	G	30901786	3	3	59	1	0	0	0	0	1	0	0	0	9132	912	32	1	112	1	LYZL2	10	30901786	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9096320	30901786	104632961	261	17064										
ANK3	288	broad.mit.edu	37	chr10	61834597	61834597	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttgcttttacttgcactctCtctggcagagatggagactg	10	9	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:61834597C>G	uc001jky.2	-	37	6234	c.6042G>C	c.(6040-6042)GAG>GAC	p.E2014D	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2014					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CTTGCACTCTCTCTGGCAGAG	0.438													0	0	0	0.01441	0	53	48										G	61834597	C	G	61834597	3	3	59	1	0	0	0	0	1	0	0	0	622	912	32	1	7432	1	ANK3	10	61834597	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	30932811	61834597	73700150	262	17065										
COL13A1	1305	broad.mit.edu	37	chr10	71716780	71716780	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggcgaagatggcttaccagtCcaaggctgctggaacaaggt	14	9	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:71716780C>G	uc001jpr.1	+	38	2669	c.2133C>G	c.(2131-2133)GTC>GTG	p.V711V	COL13A1_uc001jqj.1_Silent_p.V684V|COL13A1_uc001jps.1_Silent_p.V682V|COL13A1_uc001jpt.1_Silent_p.V670V|COL13A1_uc001jpu.1_Silent_p.V680V|COL13A1_uc001jpv.1_Silent_p.V685V|COL13A1_uc001jpx.1_Silent_p.V662V|COL13A1_uc001jpw.1_Silent_p.V658V|COL13A1_uc001jpy.1_Silent_p.V649V|COL13A1_uc001jpz.1_Silent_p.V654V|COL13A1_uc001jqa.1_Silent_p.V651V|COL13A1_uc001jqc.1_Silent_p.V696V|COL13A1_uc001jqb.1_Silent_p.V604V|COL13A1_uc001jql.2_Silent_p.V711V|COL13A1_uc001jqd.1_Silent_p.V699V|COL13A1_uc001jqe.1_Silent_p.V694V|COL13A1_uc001jqf.1_Silent_p.V692V|COL13A1_uc001jqg.1_Silent_p.V689V|COL13A1_uc001jqh.1_Silent_p.V699V|COL13A1_uc001jqi.1_Silent_p.V697V|COL13A1_uc010qjf.1_Silent_p.V486V	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	711	Extracellular (Potential).|Nonhelical region 4 (NC4).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	GCTTACCAGTCCAAGGCTGCT	0.552													0	0	0	0.007291	0	22	38										G	71716780	C	G	71716780	2	3	59	1	0	0	0	0	0	0	0	1	3670	842	30	1		1	COL13A1	10	71716780	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9882183	71716780	63817967	263	17066										
POLR3A	11128	broad.mit.edu	37	chr10	79750904	79750904	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtttttgctgagagcaggctCactgggacacgggaagactg	15	8	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:79750904C>T	uc001jzn.2	-	21	2903	c.2809G>A	c.(2809-2811)GAG>AAG	p.E937K		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	937					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AGAGCAGGCTCACTGGGACAC	0.502													0	0	0	0.003755	0	30	22										T	79750904	C	T	79750904	3	4	59	1	0	0	0	0	1	0	0	0	12228	835	29	1	1407	1	POLR3A	10	79750904	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	8034124	79750904	55783843	264	17067										
SFTPA1	653509	broad.mit.edu	37	chr10	81373716	81373716	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggtcccagccctggagacttCcgctactcagacgggacccc	11	17	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:81373716C>T	uc001kap.2	+	6	715	c.594C>T	c.(592-594)TTC>TTT	p.F198F	SFTPA1_uc001kaq.2_Silent_p.F198F|SFTPA1_uc009xry.2_Silent_p.F213F|SFTPA1_uc001kar.2_Silent_p.F198F|SFTPA1_uc010qlt.1_Silent_p.F139F|SFTPA1_uc009xrz.2_Silent_p.F128F|SFTPA1_uc009xsa.2_Silent_p.F198F|SFTPA1_uc009xsf.2_RNA	NM_005411	NP_005402	Q8IWL2	SFTA1_HUMAN	surfactant protein A1 isoform 1	198	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CTGGAGACTTCCGCTACTCAG	0.547													0	0	0	0.01441	0	82	94										T	81373716	C	T	81373716	2	4	59	1	0	0	0	0	0	0	0	1	14189	854	30	1		1	SFTPA1	10	81373716	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1622812	81373716	54161031	265	17068										
FAM35A	54537	broad.mit.edu	37	chr10	88939998	88939998	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttggaactagaaacagatgaGaacaggatctacaaacaatg	9	6	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:88939998G>A	uc001kei.3	+	7	2244	c.2130G>A	c.(2128-2130)GAG>GAA	p.E710E	FAM35A_uc001kej.3_Silent_p.E156E	NM_019054	NP_061927	Q86V20	FA35A_HUMAN	hypothetical protein LOC54537	710										ovary(2)|skin(2)	4						AAACAGATGAGAACAGGATCT	0.348													0	0	0	0.00632	0	12	17										A	88939998	G	A	88939998	2	1	59	1	0	0	0	0	0	0	0	1	5553	933	33	1		1	FAM35A	10	88939998	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7566282	88939998	46594749	266	17069										
PTEN	5728	broad.mit.edu	37	chr10	89720700	89720709	+	Frame_Shift_Del	DEL	AGGAAACCTC	AGGAAACCTC	-													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	attcttcataccaggaccagAggaaacctcagaaaaagtag							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			AGGAAACCTC	-	AGGAAACCTC	AGGAAACCTC		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:89720700_89720709delAGGAAACCTC	uc001kfb.2	+	9	1882_1891	c.851_860delAGGAAACCTC	c.(850-861)GAGGAAACCTCAfs	p.E284fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	284_287	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.E284K(1)|p.G165_*404del(1)|p.S287fs*1(1)|p.G165_K342del(1)|p.E284*(1)|p.S287fs*8(1)|p.S287fs*4(1)|p.W274_F341del(1)|p.S287*(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CCAGGACCAGAGGAAACCTCAGAAAAAGTA	0.286		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)								13	33	---	---								-	89720709	AGGAAACCTC	-	89720700	7	5	59	1	0	1	0	1	0	0	0	0	12738	304	11	0	881	0	PTEN	10	89720700	Frame_Shift_Del	DEL	AGGAAACCTC	TCGA-DK-A3IN-01A-11D-A20D-08	780702	89720700	45814047	267	17070										
TLL2	7093	broad.mit.edu	37	chr10	98155023	98155024	+	Nonsense_Mutation	DNP	CG	CG	TT													0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atccacagtctgttggagctCgatttcacatcctccggctt							TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:98155023_98155024CG>TT	uc001kml.1	-	13	1872_1873	c.1646_1647CG>AA	c.(1645-1647)TCG>TAA	p.S549*	TLL2_uc009xvf.1_Nonsense_Mutation_p.S527*	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	549	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TGTTGGAGCTCGATTTCACATC	0.49													0	0	0	0.004672	0	18	40										TT	98155024	CG	TT	98155023	4	4	59	1	0	0	0	0	0	1	0	0	15943	871	31	1	1436	1	TLL2	10	98155023	Nonsense_Mutation	DNP	CG	TCGA-DK-A3IN-01A-11D-A20D-08	8434323	98155023	37379724	268	17071										
TLL2	7093	broad.mit.edu	37	chr10	98155044	98155044	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gatttcacatcctccggcttCtcatagccacaaaagtggcc	7	14	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:98155044C>G	uc001kml.1	-	13	1852	c.1626G>C	c.(1624-1626)GAG>GAC	p.E542D	TLL2_uc009xvf.1_Missense_Mutation_p.E520D	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	542	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CCTCCGGCTTCTCATAGCCAC	0.502													0	0	0	0.013114	0	11	32										G	98155044	C	G	98155044	3	3	59	1	0	0	0	0	1	0	0	0	15943	912	32	1	1457	1	TLL2	10	98155044	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	21	98155044	37379703	269	17072										
SEC31B	25956	broad.mit.edu	37	chr10	102267742	102267742	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aactgccttgccactggggtGagcagaagacagaatgtgtt	13	8	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:102267742G>C	uc001krc.1	-	6	664	c.562C>G	c.(562-564)CAC>GAC	p.H188D	SEC31B_uc010qpo.1_Missense_Mutation_p.H187D|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_5'UTR|SEC31B_uc010qpp.1_Missense_Mutation_p.H191D|SEC31B_uc009xwn.1_Missense_Mutation_p.H188D|SEC31B_uc009xwo.1_Missense_Mutation_p.H188D|SEC31B_uc010qpq.1_Missense_Mutation_p.H31D|SEC31B_uc010qpr.1_RNA	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	188	WD 3.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CCACTGGGGTGAGCAGAAGAC	0.512													0	0	0	0.01441	0	80	88										C	102267742	G	C	102267742	3	2	59	1	0	0	0	0	1	0	0	0	13999	1290	45	1	3061	1	SEC31B	10	102267742	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4112698	102267742	33267005	270	17073										
MMP21	118856	broad.mit.edu	37	chr10	127455472	127455472	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttactgctggaaaaacttcaGtaatcctctttggataagaa	7	7	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:127455472G>C	uc001liu.2	-	7	1469	c.1469C>G	c.(1468-1470)ACT>AGT	p.T490S		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	490	Hemopexin-like 3.				proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAAAACTTCAGTAATCCTCTT	0.333													0	0	0	0.001984	0	7	31										C	127455472	G	C	127455472	3	2	59	1	0	0	0	0	1	0	0	0	9660	1029	36	4	244	4	MMP21	10	127455472	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	25187730	127455472	8079275	271	17074										
OR52B4	143496	broad.mit.edu	37	chr11	4388659	4388659	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atcccataaataatgggattCagcataggtggagccagaat	10	7	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:4388659C>T	uc010qye.1	-	1	867	c.867G>A	c.(865-867)CTG>CTA	p.L289L		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAATGGGATTCAGCATAGGTG	0.418													0	0	0	0.001855	0	12	38										T	4388659	C	T	4388659	2	4	59	1	0	0	0	0	0	0	0	1	11112	813	29	1		1	OR52B4	11	4388659	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		4388659	130617857	272	17075										
FAM160A2	84067	broad.mit.edu	37	chr11	6239209	6239209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctctgcaggggtaggccgtCggccagggctggaggcgggg	21	11	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:6239209C>T	uc001mcl.3	-	9	1966	c.1607G>A	c.(1606-1608)CGA>CAA	p.R536Q	FAM160A2_uc001mck.3_Missense_Mutation_p.R550Q|FAM160A2_uc001mcm.2_Missense_Mutation_p.R536Q	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	536					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						GGTAGGCCGTCGGCCAGGGCT	0.657													0	0	0	0.004482	0	9	34										T	6239209	C	T	6239209	3	4	59	1	0	0	0	0	1	0	0	0	5469	884	31	1	1327	1	FAM160A2	11	6239209	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1850550	6239209	128767307	273	17076										
USP47	55031	broad.mit.edu	37	chr11	11913630	11913630	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccaaagctactcctactcatCtattttgaataaatcagaaa	3	10	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:11913630C>G	uc001mjq.1	+	5	1296	c.533C>G	c.(532-534)TCT>TGT	p.S178C	USP47_uc001mjr.2_Missense_Mutation_p.S90C|USP47_uc001mjs.2_Missense_Mutation_p.S158C	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	178					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TCCTACTCATCTATTTTGAAT	0.289													0	0	0	0.006122	0	17	148										G	11913630	C	G	11913630	3	3	59	1	0	0	0	0	1	0	0	0	17075	913	32	1	279	1	USP47	11	11913630	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5674421	11913630	123092886	274	17077										
FAR1	84188	broad.mit.edu	37	chr11	13732282	13732282	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aatgatatcacgccaaaattGataggagacagacctaatac	7	8	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:13732282G>A	uc001mld.2	+	5	743	c.588G>A	c.(586-588)TTG>TTA	p.L196L	FAR1_uc009ygp.2_Silent_p.L196L	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	196					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						CGCCAAAATTGATAGGAGACA	0.333													0	0	0	0.010504	0	18	176										A	13732282	G	A	13732282	2	1	59	1	0	0	0	0	0	0	0	1	5674	1281	45	1		1	FAR1	11	13732282	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1818652	13732282	121274234	275	17078										
FAR1	84188	broad.mit.edu	37	chr11	13732293	13732293	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccaaaattgataggagacaGacctaatacatacatataca	6	8	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:13732293G>A	uc001mld.2	+	5	754	c.599G>A	c.(598-600)AGA>AAA	p.R200K	FAR1_uc009ygp.2_Missense_Mutation_p.R200K	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	200					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						ATAGGAGACAGACCTAATACA	0.348													0	0	0	0.007413	0	17	173										A	13732293	G	A	13732293	3	1	59	1	0	0	0	0	1	0	0	0	5674	942	33	1	613	1	FAR1	11	13732293	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	11	13732293	121274223	276	17079										
FAR1	84188	broad.mit.edu	37	chr11	13733312	13733312	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttaaaatttttggtattaggGatggattgataactttaatg	9	1	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:13733312G>C	uc001mld.2	+	6	880	c.725G>C	c.(724-726)GGA>GCA	p.G242A	FAR1_uc009ygp.2_Missense_Mutation_p.G242A	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	242					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						TGGTATTAGGGATGGATTGAT	0.294													0	0	0	0.004007	0	13	91										C	13733312	G	C	13733312	3	2	59	1	0	0	0	0	1	0	0	0	5674	1188	41	1	743	1	FAR1	11	13733312	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1019	13733312	121273204	277	17080										
CAPRIN1	4076	broad.mit.edu	37	chr11	34113462	34113462	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttactaacaggtgttcaatAtgaatgccccagttcctcct	6	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:34113462A>G	uc001mvh.1	+	15	1753	c.1564A>G	c.(1564-1566)ATG>GTG	p.M522V	CAPRIN1_uc001mvg.2_Missense_Mutation_p.M522V|CAPRIN1_uc001mvi.2_Missense_Mutation_p.M522V|CAPRIN1_uc001mvj.1_Missense_Mutation_p.M441V	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	522					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				GGTGTTCAATATGAATGCCCC	0.373													0	0	0	0.007413	0	15	52										G	34113462	A	G	34113462	3	3	59	1	0	0	0	0	1	0	0	0	2635	449	16	5	1618	5	CAPRIN1	11	34113462	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	20380150	34113462	100893054	278	17081										
PRDM11	56981	broad.mit.edu	37	chr11	45245797	45245797	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggttgcagagggagaagtctGagcaggttctggataaccca	15	7	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:45245797G>C	uc001myo.2	+	8	1123	c.874G>C	c.(874-876)GAG>CAG	p.E292Q		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	292										upper_aerodigestive_tract(1)	1						GGAGAAGTCTGAGCAGGTTCT	0.502													0	0	0	0.012213	0	26	138										C	45245797	G	C	45245797	3	2	59	1	0	0	0	0	1	0	0	0	12452	1291	45	1	900	1	PRDM11	11	45245797	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	11132335	45245797	89760719	279	17082										
KIAA0652	9776	broad.mit.edu	37	chr11	46679081	46679081	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tattgtattacaggcaatttGagaggaccccacctatcatg	8	9	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:46679081G>C	uc009yld.2	+	10	1288	c.604G>C	c.(604-606)GAG>CAG	p.E202Q	KIAA0652_uc001nda.2_Missense_Mutation_p.E202Q|KIAA0652_uc001ndb.2_Missense_Mutation_p.E202Q|KIAA0652_uc001ncz.2_Missense_Mutation_p.E202Q|KIAA0652_uc001ndc.2_Missense_Mutation_p.E202Q|KIAA0652_uc010rgv.1_Missense_Mutation_p.E123Q	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	202					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		CAGGCAATTTGAGAGGACCCC	0.488													0	0	0	0.014323	0	21	58										C	46679081	G	C	46679081	3	2	59	1	0	0	0	0	1	0	0	0	8188	1291	45	1	634	1	KIAA0652	11	46679081	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1433284	46679081	88327435	280	17083										
PTPRJ	5795	broad.mit.edu	37	chr11	48185099	48185099	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gacaccactgacctgctcatCaacttccggtacctcgttcg	7	16	2	1	rs2229704		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:48185099C>T	uc001ngp.3	+	23	4003	c.3648C>T	c.(3646-3648)ATC>ATT	p.I1216I		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1216	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						ACCTGCTCATCAACTTCCGGT	0.547													0	0	0	0.008361	0	28	64										T	48185099	C	T	48185099	2	4	59	1	0	0	0	0	0	0	0	1	12804	816	29	1		1	PTPRJ	11	48185099	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1506018	48185099	86821417	281	17084										
APLNR	187	broad.mit.edu	37	chr11	57003561	57003561	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcgaaaaaggcatagaggaaGgggttgaggcagctgttgac	16	5	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:57003561G>A	uc001njo.2	-	1	1367	c.918C>T	c.(916-918)CCC>CCT	p.P306P	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	306	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						CATAGAGGAAGGGGTTGAGGC	0.607													0	0	0	0.006214	0	8	44										A	57003561	G	A	57003561	2	1	59	1	0	0	0	0	0	0	0	1	777	987	35	2		2	APLNR	11	57003561	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	8818462	57003561	78002955	282	17085										
FAM111B	374393	broad.mit.edu	37	chr11	58892744	58892744	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttaatctcttaaagaattatCaaacgttgaatgaagccata	5	6	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:58892744C>G	uc001nnl.2	+	4	1417	c.1174C>G	c.(1174-1176)CAA>GAA	p.Q392E	FAM111B_uc001nnm.2_Missense_Mutation_p.Q362E|FAM111B_uc010rko.1_Missense_Mutation_p.Q362E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	392							catalytic activity			ovary(2)	2						AAAGAATTATCAAACGTTGAA	0.388													0	0	0	0.016522	0	22	66										G	58892744	C	G	58892744	3	3	59	1	0	0	0	0	1	0	0	0	5400	827	29	1	1180	1	FAM111B	11	58892744	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1889183	58892744	76113772	283	17086										
FAM111B	374393	broad.mit.edu	37	chr11	58893519	58893519	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttgtttctctgatgggtcctCaggctccccagtgtttaatg	10	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:58893519C>G	uc001nnl.2	+	4	2192	c.1949C>G	c.(1948-1950)TCA>TGA	p.S650*	FAM111B_uc001nnm.2_Nonsense_Mutation_p.S620*|FAM111B_uc010rko.1_Nonsense_Mutation_p.S620*	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	650							catalytic activity			ovary(2)	2						GATGGGTCCTCAGGCTCCCCA	0.398													0	0	0	0.013537	0	10	50										G	58893519	C	G	58893519	4	3	59	1	0	0	0	0	0	1	0	0	5400	838	29	1	1955	1	FAM111B	11	58893519	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	775	58893519	76112997	284	17087										
OR5A2	219981	broad.mit.edu	37	chr11	59190322	59190322	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caggccaacgtcaggaggtaGagccccagaaataacatgaa	11	10	1	3	rs142339235		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:59190322G>C	uc010rkt.1	-	1	105	c.105C>G	c.(103-105)CTC>CTG	p.L35L		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCAGGAGGTAGAGCCCCAGAA	0.448													0	0	0	0.004482	0	9	39										C	59190322	G	C	59190322	2	2	59	1	0	0	0	0	0	0	0	1	11140	929	33	1		1	OR5A2	11	59190322	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	296803	59190322	75816194	285	17088										
RARRES3	5920	broad.mit.edu	37	chr11	63312136	63312136	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccagtgtcttctcagtcctGagcaacagtgcagaggtgaa	11	10	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:63312136G>A	uc001nxf.3	+	3	230	c.162G>A	c.(160-162)CTG>CTA	p.L54L		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	54					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						TCTCAGTCCTGAGCAACAGTG	0.582													0	0	0	0.013726	0	32	162										A	63312136	G	A	63312136	2	1	59	1	0	0	0	0	0	0	0	1	13057	1277	45	1		1	RARRES3	11	63312136	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4121814	63312136	71694380	286	17089										
RELT	84957	broad.mit.edu	37	chr11	73102216	73102216	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggccttggggggttccccgCgttccatgtcaaccatgttc	13	13	1	0	rs146023545	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:73102216C>T	uc001otv.2	+	5	480	c.315C>T	c.(313-315)CGC>CGT	p.R105R	RELT_uc001otw.2_Silent_p.R105R|RELT_uc009yto.1_Silent_p.R23R|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	105	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						GGGTTCCCCGCGTTCCATGTC	0.587													0	0	0	0.01441	0	51	91										T	73102216	C	T	73102216	2	4	59	1	0	0	0	0	0	0	0	1	13221	755	27	2		2	RELT	11	73102216	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	9790080	73102216	61904300	287	17090										
FAT3	120114	broad.mit.edu	37	chr11	92534006	92534006	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtggaatatagagccagtgtCagggcagatgttggaagggg	18	4	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:92534006C>T	uc001pdj.3	+	9	7844	c.7827C>T	c.(7825-7827)GTC>GTT	p.V2609V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2609	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAGCCAGTGTCAGGGCAGATG	0.468										TCGA Ovarian(4;0.039)			0	0	0	0.001855	0	10	10										T	92534006	C	T	92534006	2	4	59	1	0	0	0	0	0	0	0	1	5691	813	29	1		1	FAT3	11	92534006	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	19431790	92534006	42472510	288	17091										
PVRL1	5818	broad.mit.edu	37	chr11	119545906	119545906	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acctggcctgagcgtgtaccGatggggttggtggcctcaca	15	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:119545906G>A	uc001pwv.2	-	5	1138	c.966C>T	c.(964-966)ATC>ATT	p.I322I	PVRL1_uc001pwu.1_Silent_p.I322I|PVRL1_uc001pww.2_Silent_p.I322I	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	322	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		AGCGTGTACCGATGGGGTTGG	0.602													0	0	0	0.010729	0	11	28										A	119545906	G	A	119545906	2	1	59	1	0	0	0	0	0	0	0	1	12839	1048	37	1		1	PVRL1	11	119545906	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	27011900	119545906	15460610	289	17092										
TBCEL	219899	broad.mit.edu	37	chr11	120918374	120918374	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acaaactcgaagactggcatGaggtgaagtttttatattgc	10	6	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:120918374G>A	uc009zay.2	+	3	349	c.271G>A	c.(271-273)GAG>AAG	p.E91K	TBCEL_uc001pxo.2_Missense_Mutation_p.E91K|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	91	LRR 1.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		AGACTGGCATGAGGTGAAGTT	0.368													0	0	0	0.004482	0	8	11										A	120918374	G	A	120918374	3	1	59	1	0	0	0	0	1	0	0	0	15632	1291	45	1	277	1	TBCEL	11	120918374	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1372468	120918374	14088142	290	17093										
IGSF9B	22997	broad.mit.edu	37	chr11	133792552	133792552	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atggcagctgccaagaagcaGatggtagctacgattcccgc	12	11	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:133792552G>A	uc001qgx.3	-	16	2424	c.2193C>T	c.(2191-2193)ATC>ATT	p.I731I	IGSF9B_uc001qgy.1_Silent_p.I573I	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	731	Helical; (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCAAGAAGCAGATGGTAGCTA	0.607													0	0	0	0.009096	0	4	5										A	133792552	G	A	133792552	2	1	59	1	0	0	0	0	0	0	0	1	7606	932	33	1		1	IGSF9B	11	133792552	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12874178	133792552	1213964	291	17094										
IQSEC3	440073	broad.mit.edu	37	chr12	176472	176472	+	Translation_Start_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cccagtcgccccacaagcatCtggggacacaaggggccgtg	13	15	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:176472C>G	uc001qht.1	+	1	270	c.-230C>G	c.(-232--228)ATCTG>ATGTG			NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3						regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCACAAGCATCTGGGGACACA	0.697													0	0	0	0.009096	0	3	31										G	176472	C	G	176472	1	3	59	1	0	0	0	0	0	0	0	0	7819	912	32	1		1	IQSEC3	12	176472	Translation_Start_Site	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		176472	133675423	292	17095										
KCNA5	3741	broad.mit.edu	37	chr12	5154121	5154121	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccatcatcaccttctgcttgGagaccctgcctgagttcagg	9	14	4	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:5154121G>C	uc001qni.2	+	1	1037	c.808G>C	c.(808-810)GAG>CAG	p.E270Q		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	270						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CTTCTGCTTGGAGACCCTGCC	0.657													0	0	0	0.008361	0	29	95										C	5154121	G	C	5154121	3	2	59	1	0	0	0	0	1	0	0	0	8006	1175	41	1	810	1	KCNA5	12	5154121	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4977649	5154121	128697774	293	17096										
CLEC1B	51266	broad.mit.edu	37	chr12	10145870	10145870	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	attcatatttccttttccatCttccaaaaactcaaacctgt	1	12	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:10145870C>G	uc001qwu.2	-	6	762	c.562G>C	c.(562-564)GAT>CAT	p.D188H	CLEC1B_uc009zhd.2_Missense_Mutation_p.D155H	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	188	C-type lectin.|Extracellular (Potential).			D->A: Significant reduction in rhodocytin binding.	cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						CCTTTTCCATCTTCCAAAAAC	0.358													0	0	0	0.010504	0	19	37										G	10145870	C	G	10145870	3	3	59	1	0	0	0	0	1	0	0	0	3506	913	32	1	131	1	CLEC1B	12	10145870	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4991749	10145870	123706025	294	17097										
TAS2R31	259290	broad.mit.edu	37	chr12	11183791	11183791	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctggagaccgccagagcagtGagaatctggtcagcaaaaga	13	9	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:11183791G>C	uc001qzo.1	-	1	216	c.144C>G	c.(142-144)CTC>CTG	p.L48L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	48	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						CCAGAGCAGTGAGAATCTGGT	0.368													0	0	0	0.007413	0	16	71										C	11183791	G	C	11183791	2	2	59	1	0	0	0	0	0	0	0	1	15571	1277	45	1		1	TAS2R31	12	11183791	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1037921	11183791	122668104	295	17098										
SLCO1B1	10599	broad.mit.edu	37	chr12	21325679	21325679	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	catatagaacggagatttgaGatatcctcttctcttgttgg	9	7	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:21325679G>C	uc001req.3	+	3	284	c.180G>C	c.(178-180)GAG>GAC	p.E60D		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	60	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GGAGATTTGAGATATCCTCTT	0.313													0	0	0	0.014758	0	4	17										C	21325679	G	C	21325679	3	2	59	1	0	0	0	0	1	0	0	0	14723	933	33	1	186	1	SLCO1B1	12	21325679	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	10141888	21325679	112526216	296	17099										
KIAA0528	9847	broad.mit.edu	37	chr12	22659717	22659717	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cccaacgtgtacaaggaatcCaggaggaaatgccgtcaagg	12	10	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:22659717C>T	uc001rfq.2	-	10	1303	c.1075G>A	c.(1075-1077)GGA>AGA	p.G359R	KIAA0528_uc010sir.1_Missense_Mutation_p.G152R|KIAA0528_uc010sis.1_Missense_Mutation_p.G359R|KIAA0528_uc010sit.1_Missense_Mutation_p.G361R|KIAA0528_uc010siu.1_Missense_Mutation_p.G359R|KIAA0528_uc001rfr.2_Missense_Mutation_p.G350R|KIAA0528_uc009ziy.1_Missense_Mutation_p.G361R	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	359							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						ACAAGGAATCCAGGAGGAAAT	0.373													0	0	0	0.006122	0	16	65										T	22659717	C	T	22659717	3	4	59	1	0	0	0	0	1	0	0	0	8182	603	21	2	1991	2	KIAA0528	12	22659717	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1334038	22659717	111192178	297	17100										
ARNTL2	56938	broad.mit.edu	37	chr12	27521207	27521207	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcccataggtaaagtgttgaGagaggagaaccagtgcattg	14	6	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:27521207G>C	uc001rht.1	+	2	62	c.44G>C	c.(43-45)AGA>ACA	p.R15T	ARNTL2_uc001rhw.2_Missense_Mutation_p.R26T|ARNTL2_uc010sjp.1_Missense_Mutation_p.R26T|ARNTL2_uc001rhu.1_Missense_Mutation_p.R15T|ARNTL2_uc009zji.1_Missense_Mutation_p.R15T|ARNTL2_uc001rhv.1_Missense_Mutation_p.R15T	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	15					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					AAAGTGTTGAGAGAGGAGAAC	0.413													0	0	0	0.004007	0	11	46										C	27521207	G	C	27521207	3	2	59	1	0	0	0	0	1	0	0	0	968	942	33	1	50	1	ARNTL2	12	27521207	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4861490	27521207	106330688	298	17101										
DDX11	1663	broad.mit.edu	37	chr12	31256888	31256888	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaaggtgaaacccaggaggaGagtgtggagtccagagtgct	16	6	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:31256888G>A	uc001rjt.1	+	27	3085	c.2834G>A	c.(2833-2835)AGA>AAA	p.R945K	DDX11_uc001rjr.1_3'UTR|DDX11_uc001rjs.1_3'UTR|DDX11_uc001rju.1_3'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R945K|DDX11_uc001rjw.1_3'UTR|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_Missense_Mutation_p.R114K	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	945					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CCCAGGAGGAGAGTGTGGAGT	0.602										Multiple Myeloma(12;0.14)			0	0	0	0.009096	0	4	6										A	31256888	G	A	31256888	3	1	59	1	0	0	0	0	1	0	0	0	4343	942	33	1	2941	1	DDX11	12	31256888	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3735681	31256888	102595007	299	17102										
LRRK2	120892	broad.mit.edu	37	chr12	40637439	40637439	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcattccctatgagtgaaaGaattcaagaagtgagttgct	10	6	1	5			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:40637439G>A	uc001rmg.3	+	7	915	c.794G>A	c.(793-795)AGA>AAA	p.R265K		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	265					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATGAGTGAAAGAATTCAAGAA	0.353													0	0	0	0.004007	0	16	103										A	40637439	G	A	40637439	3	1	59	1	0	0	0	0	1	0	0	0	9033	942	33	1	820	1	LRRK2	12	40637439	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9380551	40637439	93214456	300	17103										
SLC38A2	54407	broad.mit.edu	37	chr12	46761069	46761069	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctccttcattggcagtcttCaaaaggagatgaacagaata	8	9	3	3	rs61761952		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:46761069C>T	uc001rpg.2	-	5	809	c.369G>A	c.(367-369)TTG>TTA	p.L123L	SLC38A2_uc010sli.1_5'Flank|SLC38A2_uc001rph.2_Silent_p.L23L	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	123	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		TGGCAGTCTTCAAAAGGAGAT	0.338													0	0	0	0.00333	0	21	107										T	46761069	C	T	46761069	2	4	59	1	0	0	0	0	0	0	0	1	14604	825	29	1		1	SLC38A2	12	46761069	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6123630	46761069	87090826	301	17104										
MLL2	8085	broad.mit.edu	37	chr12	49434740	49434740	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aaaggtgggggcgagagcagGggctcggaagctttgcctcc	18	9	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:49434740G>T	uc001rta.3	-	31	6813	c.6813C>A	c.(6811-6813)CCC>CCA	p.P2271P		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2271	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCGAGAGCAGGGGCTCGGAAG	0.632			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	3.86212e-05	0.008291	4.00269e-05	7	38										T	49434740	G	T	49434740	2	4	59	1	0	0	0	0	0	0	0	1	9621	1219	43	4		4	MLL2	12	49434740	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2673671	49434740	84417155	302	17105										
DAZAP2	9802	broad.mit.edu	37	chr12	51634657	51634657	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctcttctgcctcttctagctCtatcgtccgagctttgtgca	7	14	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:51634657C>T	uc010snd.1	+	3	319	c.135C>T	c.(133-135)CTC>CTT	p.L45L	DAZAP2_uc001ryb.2_Silent_p.L45L|DAZAP2_uc010snc.1_Intron|DAZAP2_uc010sne.1_Intron|DAZAP2_uc010snf.1_Silent_p.L45L	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	45	Pro-rich.						WW domain binding				0						TCTTCTAGCTCTATCGTCCGA	0.473													0	0	0	0.012319	0	17	71										T	51634657	C	T	51634657	2	4	59	1	0	0	0	0	0	0	0	1	4245	900	32	1		1	DAZAP2	12	51634657	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2199917	51634657	82217238	303	17106										
GALNT6	11226	broad.mit.edu	37	chr12	51759227	51759227	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tactcacagtgggcatccagGaacgtgagcacctccgcctg	11	14	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:51759227G>A	uc001ryk.2	-	4	1026	c.801C>T	c.(799-801)TTC>TTT	p.F267F	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.F267F	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	267	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GGGCATCCAGGAACGTGAGCA	0.687													0	0	0	0.014758	0	4	51										A	51759227	G	A	51759227	2	1	59	1	0	0	0	0	0	0	0	1	6217	1165	41	1		1	GALNT6	12	51759227	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	124570	51759227	82092668	304	17107										
TENC1	23371	broad.mit.edu	37	chr12	53444019	53444019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctcagagccctggggaggaGggacagcagccgggccgcaa	18	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:53444019G>A	uc001sbp.2	+	1	185	c.50G>A	c.(49-51)AGG>AAG	p.R17K	uc001sbk.1_Intron|TENC1_uc001sbl.2_Intron|TENC1_uc001sbm.2_Intron|TENC1_uc001sbn.2_Intron|TENC1_uc001sbo.1_Missense_Mutation_p.R17K	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	17					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						CTGGGGAGGAGGGACAGCAGC	0.692													0	0	0	0.014758	0	4	11										A	53444019	G	A	53444019	3	1	59	1	0	0	0	0	1	0	0	0	15755	1000	35	2	161	2	TENC1	12	53444019	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1684792	53444019	80407876	305	17108										
KIAA0748	9840	broad.mit.edu	37	chr12	55356465	55356465	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctctctccttatctgagctGggtctgtgctccactgtgga	11	12	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:55356465G>A	uc001sgn.3	-	9	1327	c.1217C>T	c.(1216-1218)CCA>CTA	p.P406L	KIAA0748_uc001sgl.3_Missense_Mutation_p.P268L|KIAA0748_uc001sgm.3_Missense_Mutation_p.P153L|KIAA0748_uc010spb.1_Missense_Mutation_p.P153L|KIAA0748_uc010spc.1_Missense_Mutation_p.P268L|KIAA0748_uc010spd.1_Missense_Mutation_p.P406L|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	406										ovary(1)|central_nervous_system(1)	2						TATCTGAGCTGGGTCTGTGCT	0.507													0	0	0	0.00874	0	39	65										A	55356465	G	A	55356465	3	1	59	1	0	0	0	0	1	0	0	0	8190	1348	47	2	356	2	KIAA0748	12	55356465	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1912446	55356465	78495430	306	17109										
OR6C3	254786	broad.mit.edu	37	chr12	55725670	55725670	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atgtatttcttcctccggaaCttctctttcttagaaatctc	4	11	4	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:55725670C>T	uc010spj.1	+	1	186	c.186C>T	c.(184-186)AAC>AAT	p.N62N		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCCTCCGGAACTTCTCTTTCT	0.403													0	0	0	0.014323	0	21	91										T	55725670	C	T	55725670	2	4	59	1	0	0	0	0	0	0	0	1	11192	564	20	2		2	OR6C3	12	55725670	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	369205	55725670	78126225	307	17110										
SILV	6490	broad.mit.edu	37	chr12	56351375	56351375	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gagctggagggcaaaggtcaGaggctgatttctcaggaagt	16	6	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:56351375G>A	uc001sip.2	-	6	743	c.712C>T	c.(712-714)CTG>TTG	p.L238L	SILV_uc001siq.2_Silent_p.L238L|SILV_uc010spx.1_Silent_p.L152L|SILV_uc001sir.2_Silent_p.L238L	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	238					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GCAAAGGTCAGAGGCTGATTT	0.562													0	0	0	0.011902	0	38	114										A	56351375	G	A	56351375	2	1	59	1	0	0	0	0	0	0	0	1	14322	933	33	1		1	SILV	12	56351375	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	625705	56351375	77500520	308	17111										
ERBB3	2065	broad.mit.edu	37	chr12	56480410	56480410	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcgtgagggaccgagatgctGagatagtggtgaaggacaat	16	5	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:56480410G>A	uc001sjh.2	+	4	710	c.517G>A	c.(517-519)GAG>AAG	p.E173K	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.E114K|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	173	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCGAGATGCTGAGATAGTGGT	0.493													0	0	0	0.01441	0	44	102										A	56480410	G	A	56480410	3	1	59	1	0	0	0	0	1	0	0	0	5208	1291	45	1	662	1	ERBB3	12	56480410	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	129035	56480410	77371485	309	17112										
TRHDE	29953	broad.mit.edu	37	chr12	72666768	72666768	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgcttcgacgagtgcggggcGagtgccacgccaggcgccga	17	14	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:72666768G>C	uc001sxa.2	+	1	240	c.210G>C	c.(208-210)GCG>GCC	p.A70A	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	70	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AGTGCGGGGCGAGTGCCACGC	0.706													0	0	0	0.009096	0	4	4										C	72666768	G	C	72666768	2	2	59	1	0	0	0	0	0	0	0	1	16476	1045	37	1		1	TRHDE	12	72666768	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	16186358	72666768	61185127	310	17113										
GLIPR1L1	256710	broad.mit.edu	37	chr12	75728668	75728668	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aagtcaaccctcccgcggccGacatgaaatacatggtgaga	10	12	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:75728668G>A	uc001sxo.2	+	1	206	c.160G>A	c.(160-162)GAC>AAC	p.D54N	CAPS2_uc001sxm.3_Intron|CAPS2_uc009zsa.2_Intron|GLIPR1L1_uc001sxn.2_Missense_Mutation_p.D54N	NM_152779	NP_689992	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	54						extracellular region					0						TCCCGCGGCCGACATGAAATA	0.473											OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	15	46										A	75728668	G	A	75728668	3	1	59	1	0	0	0	0	1	0	0	0	6442	1058	37	1	162	1	GLIPR1L1	12	75728668	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3061900	75728668	58123227	311	17114										
LRRIQ1	84125	broad.mit.edu	37	chr12	85434370	85434370	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttcaggacctggaagatactGatattttaagtaagtactat	8	5	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:85434370G>A	uc001tac.2	+	3	346	c.235G>A	c.(235-237)GAT>AAT	p.D79N	LRRIQ1_uc001tab.1_Missense_Mutation_p.D79N|LRRIQ1_uc001taa.1_Missense_Mutation_p.D79N|LRRIQ1_uc001tad.2_5'UTR	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	79										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GGAAGATACTGATATTTTAAG	0.313													0	0	0	0.013537	0	9	54										A	85434370	G	A	85434370	3	1	59	1	0	0	0	0	1	0	0	0	9029	1290	45	1	241	1	LRRIQ1	12	85434370	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9705702	85434370	48417525	312	17115										
NT5DC3	51559	broad.mit.edu	37	chr12	104190738	104190738	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttgaggaagtattcattcacGcaggacaggagggtcatctc	12	8	4	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:104190738G>A	uc010swe.1	-	6	728	c.687C>T	c.(685-687)TGC>TGT	p.C229C		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	229							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						ATTCATTCACGCAGGACAGGA	0.478													0	0	0	0.010504	0	20	103										A	104190738	G	A	104190738	2	1	59	1	0	0	0	0	0	0	0	1	10692	1079	38	2		2	NT5DC3	12	104190738	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	18756368	104190738	29661157	313	17116										
TCP11L2	255394	broad.mit.edu	37	chr12	106740114	106740114	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tactttgtcttccaagccctCaaaaatgcatgcctcctatg	5	13	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:106740114C>G	uc001tln.2	+	10	1540	c.1366C>G	c.(1366-1368)CAA>GAA	p.Q456E		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	456										ovary(3)	3						TCCAAGCCCTCAAAAATGCAT	0.398													0	0	0	0.010729	0	12	21										G	106740114	C	G	106740114	3	3	59	1	0	0	0	0	1	0	0	0	15712	827	29	1	1400	1	TCP11L2	12	106740114	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2549376	106740114	27111781	314	17117										
TCP11L2	255394	broad.mit.edu	37	chr12	106740204	106740204	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aatatgcaaacattgtgaatCtcaacaaacaagtgtatgga	7	6	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:106740204C>T	uc001tln.2	+	10	1630	c.1456C>T	c.(1456-1458)CTC>TTC	p.L486F		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	486										ovary(3)	3						CATTGTGAATCTCAACAAACA	0.453													0	0	0	0.00308	0	7	36										T	106740204	C	T	106740204	3	4	59	1	0	0	0	0	1	0	0	0	15712	913	32	1	1490	1	TCP11L2	12	106740204	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	90	106740204	27111691	315	17118										
PRDM4	11108	broad.mit.edu	37	chr12	108145485	108145485	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggcactgtcagacatgccaTtgacccgacttgcaatgtgg	12	11	1	2	rs148244009		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:108145485T>A	uc001tmp.2	-	5	1270	c.833A>T	c.(832-834)AAT>ATT	p.N278I	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	278					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGACATGCCATTGACCCGACT	0.557													0	0	0	0.00245	0	11	40										A	108145485	T	A	108145485	3	1	59	1	0	0	0	0	1	0	0	0	12459	1493	52	5	1604	5	PRDM4	12	108145485	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	1405281	108145485	25706410	316	17119										
VSIG10	54621	broad.mit.edu	37	chr12	118533368	118533368	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagccacacttggaaccactGagtcacattcaggatctcct	7	14	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:118533368G>A	uc001tws.2	-	2	665	c.331C>T	c.(331-333)CAG>TAG	p.Q111*		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	111	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane					0						TGGAACCACTGAGTCACATTC	0.577													0	0	0	0.004656	0	21	133										A	118533368	G	A	118533368	4	1	59	1	0	0	0	0	0	1	0	0	17220	1299	45	1	1323	1	VSIG10	12	118533368	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	10387883	118533368	15318527	317	17120										
CIT	11113	broad.mit.edu	37	chr12	120173111	120173111	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaagttttggttgttgagttCagcgttgtcctcggtcagct	13	7	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:120173111C>T	uc001txi.1	-	24	2937	c.2884G>A	c.(2884-2886)GAA>AAA	p.E962K	CIT_uc001txh.1_Missense_Mutation_p.E496K|CIT_uc001txj.1_Missense_Mutation_p.E1004K	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	962	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTGTTGAGTTCAGCGTTGTCC	0.478													0	0	0	0.008291	0	10	87										T	120173111	C	T	120173111	3	4	59	1	0	0	0	0	1	0	0	0	3438	835	29	1	3295	1	CIT	12	120173111	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1639743	120173111	13678784	318	17121										
GATC	283459	broad.mit.edu	37	chr12	120884567	120884567	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctggagaaagctatcgccttCgccgaccggctacgcgccgt	12	15	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:120884567C>T	uc010szi.1	+	2	189	c.189C>T	c.(187-189)TTC>TTT	p.F63F	TRIAP1_uc001tyg.2_5'Flank	NM_176818	NP_789788	O43716	GATCL_HUMAN	glutamyl-tRNA(Gln) amidotransferase, subunit C	63					regulation of translational fidelity						0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTATCGCCTTCGCCGACCGGC	0.667													0	0	0	0.00245	0	12	29										T	120884567	C	T	120884567	2	4	59	1	0	0	0	0	0	0	0	1	6262	883	31	1		1	GATC	12	120884567	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	711456	120884567	12967328	319	17122										
RNF10	9921	broad.mit.edu	37	chr12	120995453	120995453	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggctttgcccaaatccaaatGgatgaatgtagaccatccca	8	11	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:120995453G>A	uc001typ.3	+	6	1418	c.935G>A	c.(934-936)TGG>TAG	p.W312*	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Nonsense_Mutation_p.W218*	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	312					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAATCCAAATGGATGAATGTA	0.413													0	0	0	0.016522	0	21	93										A	120995453	G	A	120995453	4	1	59	1	0	0	0	0	0	1	0	0	13422	1357	47	2	957	2	RNF10	12	120995453	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	110886	120995453	12856442	320	17123										
BRI3BP	140707	broad.mit.edu	37	chr12	125509837	125509837	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcccatgggcttctactggcGaagcagtcccagcggcccca	12	16	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:125509837G>A	uc001uha.1	+	3	760	c.617G>A	c.(616-618)CGA>CAA	p.R206Q		NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	BRI3-binding protein	206						integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		TTCTACTGGCGAAGCAGTCCC	0.542													0	0	0	0.014758	0	3	19										A	125509837	G	A	125509837	3	1	59	1	0	0	0	0	1	0	0	0	1513	1058	37	1	627	1	BRI3BP	12	125509837	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4514384	125509837	8342058	321	17124										
RIMBP2	23504	broad.mit.edu	37	chr12	130919336	130919336	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accgaggcgcccctcctcttGaagtctggagagtcataggc	12	13	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:130919336G>A	uc001uil.2	-	11	2309	c.2145C>T	c.(2143-2145)TTC>TTT	p.F715F	RIMBP2_uc001uim.2_Silent_p.F623F|RIMBP2_uc001uin.1_Silent_p.F374F	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	715						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCCTCCTCTTGAAGTCTGGAG	0.612													0	0	0	0.00308	0	7	67										A	130919336	G	A	130919336	2	1	59	1	0	0	0	0	0	0	0	1	13363	1281	45	1		1	RIMBP2	12	130919336	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5409499	130919336	2932559	322	17125										
EP400	57634	broad.mit.edu	37	chr12	132502128	132502128	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttgtcaacgtcctgagcatCcttgtgcggctgcagcgcat	11	12	1	1	rs138508770		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:132502128C>T	uc001ujn.2	+	19	4007	c.3972C>T	c.(3970-3972)ATC>ATT	p.I1324I	EP400_uc001ujl.2_Silent_p.I1323I|EP400_uc001ujm.2_Silent_p.I1324I	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1360	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCCTGAGCATCCTTGTGCGGC	0.607													0	0	0	0.009535	0	28	59										T	132502128	C	T	132502128	2	4	59	1	0	0	0	0	0	0	0	1	5149	845	30	1		1	EP400	12	132502128	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1582792	132502128	1349767	323	17126										
EP400	57634	broad.mit.edu	37	chr12	132522554	132522554	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atggatgatgctggcttcccGgtcaaagctgaggagtttgt	14	7	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:132522554G>A	uc001ujn.2	+	31	6155	c.6120G>A	c.(6118-6120)CCG>CCA	p.P2040P	EP400_uc001ujl.2_Silent_p.P2039P|EP400_uc001ujm.2_Silent_p.P1959P	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2076					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTGGCTTCCCGGTCAAAGCTG	0.463													0	0	0	0.01441	0	49	82										A	132522554	G	A	132522554	2	1	59	1	0	0	0	0	0	0	0	1	5149	1103	39	2		2	EP400	12	132522554	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	20426	132522554	1329341	324	17127										
RB1	5925	broad.mit.edu	37	chr13	49039354	49039354	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctctagccccctaccttgtCaccaatacctcacattcctc	3	19	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr13:49039354C>A	uc001vcb.2	+	23	2505	c.2339C>A	c.(2338-2340)TCA>TAA	p.S780*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	780	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTACCTTGTCACCAATACCT	0.388		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			1	0	1.00798e-23	0.01441	1.08413e-23	46	67										A	49039354	C	A	49039354	4	1	59	1	0	0	0	0	0	1	0	0	13098	838	29	3	2429	3	RB1	13	49039354	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		49039354	66130524	325	17128										
PCDH17	27253	broad.mit.edu	37	chr13	58208645	58208645	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caccctttctgggaggacgtGacgcccgtggtggagctggt	16	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr13:58208645G>A	uc001vhq.1	+	1	2857	c.1965G>A	c.(1963-1965)GTG>GTA	p.V655V	PCDH17_uc010aec.1_Silent_p.V655V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGGAGGACGTGACGCCCGTGG	0.637													0	0	0	0.01441	0	61	107										A	58208645	G	A	58208645	2	1	59	1	0	0	0	0	0	0	0	1	11512	1277	45	1		1	PCDH17	13	58208645	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	9169291	58208645	56961233	326	17129										
CUL4A	8451	broad.mit.edu	37	chr13	113900284	113900284	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttttagcatatgcagaatcaGagtgactcaggccctataga	9	8	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr13:113900284G>T	uc010tjy.1	+	16	1556	c.1545G>T	c.(1543-1545)CAG>CAT	p.Q515H	CUL4A_uc010tjx.1_Missense_Mutation_p.Q415H|CUL4A_uc010agu.2_Missense_Mutation_p.Q376H|CUL4A_uc010tjz.1_Missense_Mutation_p.Q194H	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	515					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TGCAGAATCAGAGTGACTCAG	0.383													1	0	2.27111e-07	0.013537	2.38114e-07	10	26										T	113900284	G	T	113900284	3	4	59	1	0	0	0	0	1	0	0	0	4057	933	33	3	1603	3	CUL4A	13	113900284	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	55691639	113900284	1269594	327	17130										
RNASE3	6037	broad.mit.edu	37	chr14	21360150	21360150	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caacaattgtcatcggagtaGattccgggtgcctttactcc	9	11	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:21360150G>T	uc001vyj.2	+	2	359	c.305G>T	c.(304-306)AGA>ATA	p.R102I		NM_002935	NP_002926	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3 (eosinophil	102					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	CATCGGAGTAGATTCCGGGTG	0.418													1	0	2.05212e-20	0.005524	2.19841e-20	34	67										T	21360150	G	T	21360150	3	4	59	1	0	0	0	0	1	0	0	0	13405	942	33	3	307	3	RNASE3	14	21360150	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		21360150	85989390	328	17131										
MYH7	4625	broad.mit.edu	37	chr14	23886487	23886487	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tctgcgaggactccagctccGactgcgactcctcatacttc	8	16	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:23886487G>A	uc001wjx.2	-	32	4500	c.4394C>T	c.(4393-4395)TCG>TTG	p.S1465L		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1465	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTCCAGCTCCGACTGCGACTC	0.602													0	0	0	0.00333	0	23	64										A	23886487	G	A	23886487	3	1	59	1	0	0	0	0	1	0	0	0	10039	1059	37	1	1449	1	MYH7	14	23886487	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2526337	23886487	83463053	329	17132										
REC8	9985	broad.mit.edu	37	chr14	24647296	24647296	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgccctccccactcaacaGaggaggcccccagtcccccc	7	23	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:24647296G>C	uc001wmr.2	+	14	1292	c.865_splice	c.e14-1	p.R289_splice	REC8_uc001wms.2_Splice_Site_p.R289_splice	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog						mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		CCACTCAACAGAGGAGGCCCC	0.622													0	0	0	0.008871	0	16	49										C	24647296	G	C	24647296	5	2	59	1	0	0	0	0	0	0	1	0	13199	956	33	1	907	1	REC8	14	24647296	Splice_Site	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	760809	24647296	82702244	330	17133										
EAPP	55837	broad.mit.edu	37	chr14	35008795	35008795	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctcctcgtcgctaggctcttCaaccgcgtaggggtcgtagt	12	13	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:35008795C>T	uc001wsd.1	-	1	149	c.40G>A	c.(40-42)GAA>AAA	p.E14K		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	14					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		CTAGGCTCTTCAACCGCGTAG	0.627													0	0	0	0.00308	0	6	26										T	35008795	C	T	35008795	3	4	59	1	0	0	0	0	1	0	0	0	4877	835	29	1	841	1	EAPP	14	35008795	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	10361499	35008795	72340745	331	17134										
YLPM1	56252	broad.mit.edu	37	chr14	75230697	75230697	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtcttacatgcccccacctCagccgccaccctcttactac	4	20	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:75230697C>T	uc001xqj.3	+	1	629	c.505C>T	c.(505-507)CAG>TAG	p.Q169*		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCCCCCACCTCAGCCGCCACC	0.622													0	0	0	0.004482	0	9	17										T	75230697	C	T	75230697	4	4	59	1	0	0	0	0	0	1	0	0	17483	827	29	1	507	1	YLPM1	14	75230697	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	40221902	75230697	32118843	332	17135										
POMT2	29954	broad.mit.edu	37	chr14	77772681	77772681	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcaagtcaggaagccttactCctctcattcccatgtagctg	7	13	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:77772681C>G	uc001xti.2	-	3	638	c.437G>C	c.(436-438)GGA>GCA	p.G146A	POMT2_uc010asr.2_Missense_Mutation_p.G35A	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	146	Helical; (Potential).				protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		AAGCCTTACTCCTCTCATTCC	0.483													0	0	0	0.013537	0	12	35										G	77772681	C	G	77772681	3	3	59	1	0	0	0	0	1	0	0	0	12246	869	30	1	1891	1	POMT2	14	77772681	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2541984	77772681	29576859	333	17136										
TSHR	7253	broad.mit.edu	37	chr14	81609785	81609785	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aacctggcctttgcggatttCtgcatggggatgtacctgct	12	10	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:81609785C>G	uc001xvd.1	+	10	1539	c.1383C>G	c.(1381-1383)TTC>TTG	p.F461L		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	461	Helical; Name=2; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TTGCGGATTTCTGCATGGGGA	0.542			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						0	0	0	0.015359	0	31	86										G	81609785	C	G	81609785	3	3	59	1	0	0	0	0	1	0	0	0	16619	912	32	1	1558	1	TSHR	14	81609785	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3837104	81609785	25739755	334	17137										
ZC3H14	79882	broad.mit.edu	37	chr14	89038435	89038435	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtaacgtgccttcaaacaaGagcaatttcagtcggggaga	11	8	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:89038435G>C	uc001xww.2	+	5	522	c.297G>C	c.(295-297)AAG>AAC	p.K99N	ZC3H14_uc010twd.1_Missense_Mutation_p.K99N|ZC3H14_uc010twe.1_Missense_Mutation_p.K99N|ZC3H14_uc001xwx.2_Missense_Mutation_p.K99N|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Missense_Mutation_p.K65N|ZC3H14_uc010twg.1_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	99						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CTTCAAACAAGAGCAATTTCA	0.413													0	0	0	0.008871	0	18	77										C	89038435	G	C	89038435	3	2	59	1	0	0	0	0	1	0	0	0	17563	933	33	1	315	1	ZC3H14	14	89038435	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7428650	89038435	18311105	335	17138										
SERPINA10	51156	broad.mit.edu	37	chr14	94754876	94754876	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gacttcggtgaagacagggtCaaatggggtcaaccatttcc	12	9	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:94754876C>G	uc001yct.2	-	3	1205	c.739G>C	c.(739-741)GAC>CAC	p.D247H	SERPINA10_uc001ycu.3_Missense_Mutation_p.D247H	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	247					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		AAGACAGGGTCAAATGGGGTC	0.453													0	0	0	0.007291	0	25	83										G	94754876	C	G	94754876	3	3	59	1	0	0	0	0	1	0	0	0	14087	826	29	1	607	1	SERPINA10	14	94754876	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5716441	94754876	12594664	336	17139										
SETD3	84193	broad.mit.edu	37	chr14	99871626	99871626	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctccaagctttattttcactCtgtcgtgtgagttattgtca	7	9	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:99871626C>T	uc001ygc.2	-	10	1177	c.1007G>A	c.(1006-1008)AGA>AAA	p.R336K		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	336					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				TATTTTCACTCTGTCGTGTGA	0.438													0	0	0	0.00632	0	29	62										T	99871626	C	T	99871626	3	4	59	1	0	0	0	0	1	0	0	0	14132	913	32	1	793	1	SETD3	14	99871626	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5116750	99871626	7477914	337	17140										
ARHGAP11B	89839	broad.mit.edu	37	chr15	30926523	30926523	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aagctcaacagttaggcacaGaggaaaagaataaagctata	9	6	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:30926523G>A	uc001zet.1	+	4	593	c.448G>A	c.(448-450)GAG>AAG	p.E150K	ARHGAP11B_uc010azv.1_RNA|ARHGAP11B_uc001zeu.2_RNA	NM_001039841	NP_001034930	Q3KRB8	RHGBB_HUMAN	Rho GTPase activating protein 11B	150	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		GTTAGGCACAGAGGAAAAGAA	0.413													0	0	0	0.010504	0	15	57										A	30926523	G	A	30926523	3	1	59	1	0	0	0	0	1	0	0	0	864	943	33	1	462	1	ARHGAP11B	15	30926523	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		30926523	71604869	338	17141										
TRPM1	4308	broad.mit.edu	37	chr15	31318357	31318357	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cgtacctttcagaagtgaccCggatgcgctcgtcgctggac	12	13	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:31318357C>A	uc001zfm.2	-	26	3676	c.3548G>T	c.(3547-3549)CGG>CTG	p.R1183L	TRPM1_uc010azy.2_Missense_Mutation_p.R1090L|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1183	Potential.|Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGAAGTGACCCGGATGCGCTC	0.622													1	0	2.31682e-05	0.003163	2.40576e-05	14	38										A	31318357	C	A	31318357	3	1	59	1	0	0	0	0	1	0	0	0	16582	652	23	4	1271	4	TRPM1	15	31318357	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	391834	31318357	71213035	339	17142										
CAPN3	825	broad.mit.edu	37	chr15	42703970	42703970	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcagctcaccatgtatgcctGaaccaggctggcctcatcca	9	15	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:42703970G>C	uc001zpn.1	+	24	2771	c.2465G>C	c.(2464-2466)TGA>TCA	p.*822S	CAPN3_uc001zpk.1_Nonstop_Mutation_p.*589S|CAPN3_uc001zpl.1_Nonstop_Mutation_p.*729S|CAPN3_uc010udf.1_Nonstop_Mutation_p.*735S|CAPN3_uc010udg.1_Nonstop_Mutation_p.*687S|CAPN3_uc001zpo.1_Nonstop_Mutation_p.*816S|CAPN3_uc001zpp.1_Nonstop_Mutation_p.*730S|CAPN3_uc001zpq.1_Nonstop_Mutation_p.*310S|CAPN3_uc010bcv.1_Intron|CAPN3_uc001zpr.1_Nonstop_Mutation_p.*157S|CAPN3_uc001zps.1_Nonstop_Mutation_p.*157S|CAPN3_uc001zpt.1_Nonstop_Mutation_p.*157S	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	822					muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		ATGTATGCCTGAACCAGGCTG	0.517													0	0	0	0.00308	0	6	49										C	42703970	G	C	42703970	4	2	59	1	0	0	0	0	0	0	0	0	2628	1285	45	1	2611	1	CAPN3	15	42703970	Nonstop_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	11385613	42703970	59827422	340	17143										
IGDCC4	57722	broad.mit.edu	37	chr15	65681731	65681731	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aatggcttcaagccgccaatGaggatgtcttctccagaact	9	11	3	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:65681731G>T	uc002aou.1	-	14	2637	c.2427C>A	c.(2425-2427)CTC>CTA	p.L809L	IGDCC4_uc002aot.1_Silent_p.L397L	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	809	Fibronectin type-III 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						AGCCGCCAATGAGGATGTCTT	0.562													1	0	0.000274275	0.004482	0.000282634	7	51										T	65681731	G	T	65681731	2	4	59	1	0	0	0	0	0	0	0	1	7569	1277	45	3		3	IGDCC4	15	65681731	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	22977761	65681731	36849661	341	17144										
SMAD3	4088	broad.mit.edu	37	chr15	67457635	67457635	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccacacagagatcccggccGagttccccccactggacgac	10	18	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:67457635G>A	uc002aqj.2	+	3	743	c.445G>A	c.(445-447)GAG>AAG	p.E149K	SMAD3_uc010ujr.1_Missense_Mutation_p.E44K|SMAD3_uc010ujs.1_Missense_Mutation_p.E105K|SMAD3_uc010ujt.1_5'Flank	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	149	Linker.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GATCCCGGCCGAGTTCCCCCC	0.602													0	0	0	0.008361	0	31	153										A	67457635	G	A	67457635	3	1	59	1	0	0	0	0	1	0	0	0	14759	1059	37	1	533	1	SMAD3	15	67457635	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1775904	67457635	35073757	342	17145										
SMAD3	4088	broad.mit.edu	37	chr15	67473650	67473650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actacgagctgaaccagcgcGtcggggagacattccacgcc	12	14	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:67473650G>A	uc002aqj.2	+	6	1028	c.730G>A	c.(730-732)GTC>ATC	p.V244I	SMAD3_uc010ujr.1_Missense_Mutation_p.V139I|SMAD3_uc010ujs.1_Missense_Mutation_p.V200I|SMAD3_uc010ujt.1_Missense_Mutation_p.V49I	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	244	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GAACCAGCGCGTCGGGGAGAC	0.607													0	0	0	0.006214	0	8	52										A	67473650	G	A	67473650	3	1	59	1	0	0	0	0	1	0	0	0	14759	1145	40	2	830	2	SMAD3	15	67473650	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	16015	67473650	35057742	343	17146										
LMAN1L	79748	broad.mit.edu	37	chr15	75112416	75112416	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtcctgtccttcctgaccttCagcctgagtgagcccagccc	9	17	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:75112416C>T	uc002ayt.1	+	7	752	c.750C>T	c.(748-750)TTC>TTT	p.F250F	LMAN1L_uc010bkd.2_3'UTR|LMAN1L_uc010ulo.1_3'UTR|LMAN1L_uc010bke.1_Intron	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	250	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						TCCTGACCTTCAGCCTGAGTG	0.612													0	0	0	0.012319	0	17	100										T	75112416	C	T	75112416	2	4	59	1	0	0	0	0	0	0	0	1	8837	825	29	1		1	LMAN1L	15	75112416	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	7638766	75112416	27418976	344	17147										
TBC1D2B	23102	broad.mit.edu	37	chr15	78346479	78346479	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctgttacaatattcccatctCttctgctgaagctcctgtaa	5	12	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:78346479C>T	uc002bcy.3	-	2	411	c.411G>A	c.(409-411)AAG>AAA	p.K137K	TBC1D2B_uc010bla.2_Silent_p.K137K	NM_144572	NP_653173	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B isoform a	137	PH.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)|large_intestine(1)|breast(1)	3						ATTCCCATCTCTTCTGCTGAA	0.468													0	0	0	0.001855	0	12	45										T	78346479	C	T	78346479	2	4	59	1	0	0	0	0	0	0	0	1	15616	912	32	1		1	TBC1D2B	15	78346479	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3234063	78346479	24184913	345	17148										
WDR90	197335	broad.mit.edu	37	chr16	716290	716290	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccctgcacagggacaaccttCcgtgtgctgagtgaccacca	10	15	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:716290C>T	uc002cii.1	+	37	4734	c.4680C>T	c.(4678-4680)TTC>TTT	p.F1560F	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Silent_p.F175F|WDR90_uc010uul.1_Silent_p.F159F|WDR90_uc002cio.1_Silent_p.F159F|WDR90_uc010bqx.1_Silent_p.F159F|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1560	WD 19.									ovary(1)	1		Hepatocellular(780;0.0218)				GGACAACCTTCCGTGTGCTGA	0.627													0	0	0	0.004007	0	13	44										T	716290	C	T	716290	2	4	59	1	0	0	0	0	0	0	0	1	17334	854	30	1		1	WDR90	16	716290	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		716290	89638463	346	17149										
CCNF	899	broad.mit.edu	37	chr16	2495468	2495468	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tctttccgcaggtacattctGatcgactggctggtggaagt	12	9	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:2495468G>A	uc002cqd.1	+	10	1027	c.939G>A	c.(937-939)CTG>CTA	p.L313L	CCNF_uc002cqe.1_Silent_p.L5L	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	313	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GGTACATTCTGATCGACTGGC	0.592													0	0	0	0.016522	0	17	92										A	2495468	G	A	2495468	2	1	59	1	0	0	0	0	0	0	0	1	2922	1277	45	1		1	CCNF	16	2495468	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1779178	2495468	87859285	347	17150										
PRSS21	10942	broad.mit.edu	37	chr16	2871063	2871063	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tccgcaaggacatctttggaGacatggtttgtgctggcaat	12	8	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:2871063G>A	uc002crt.2	+	5	764	c.658G>A	c.(658-660)GAC>AAC	p.D220N	PRSS21_uc002crs.2_Missense_Mutation_p.D218N|PRSS21_uc002crr.2_Missense_Mutation_p.D220N	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	220	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						CATCTTTGGAGACATGGTTTG	0.537													0	0	0	0.01441	0	54	206										A	2871063	G	A	2871063	3	1	59	1	0	0	0	0	1	0	0	0	12618	942	33	1	676	1	PRSS21	16	2871063	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	375595	2871063	87483690	348	17151										
UBN1	29855	broad.mit.edu	37	chr16	4924307	4924307	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gatcaccaaacaggaggcctGagtattggggcctcgagcag	14	10	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4924307G>C	uc002cyb.2	+	15	2235	c.1896G>C	c.(1894-1896)CTG>CTC	p.L632L	UBN1_uc010uxw.1_Silent_p.L632L|UBN1_uc002cyc.2_Silent_p.L632L	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	632					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CAGGAGGCCTGAGTATTGGGG	0.542													0	0	0	0.00333	0	21	98										C	4924307	G	C	4924307	2	2	59	1	0	0	0	0	0	0	0	1	16889	1277	45	1		1	UBN1	16	4924307	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2053244	4924307	85430446	349	17152			5	69		6	6	10431	N	G_C	6.89832e-07
UBN1	29855	broad.mit.edu	37	chr16	4924679	4924679	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tctcaggagaaaaaaccagaGagttctggctacaaagagct	10	8	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4924679G>C	uc002cyb.2	+	15	2607	c.2268G>C	c.(2266-2268)GAG>GAC	p.E756D	UBN1_uc010uxw.1_Missense_Mutation_p.E756D|UBN1_uc002cyc.2_Missense_Mutation_p.E756D	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	756					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AAAAACCAGAGAGTTCTGGCT	0.552													0	0	0	0.007413	0	17	58										C	4924679	G	C	4924679	3	2	59	1	0	0	0	0	1	0	0	0	16889	933	33	1	2322	1	UBN1	16	4924679	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	372	4924679	85430074	350	17153			5	69		6	6	10431	N	G_C	6.89832e-07
UBN1	29855	broad.mit.edu	37	chr16	4927465	4927465	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtgcccacccatatcccgcaGagtctgccaggtaatcaccc	8	17	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4927465G>C	uc002cyb.2	+	17	3684	c.3345G>C	c.(3343-3345)CAG>CAC	p.Q1115H	UBN1_uc010uxw.1_Intron|UBN1_uc002cyc.2_Missense_Mutation_p.Q1115H	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	1115					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ATATCCCGCAGAGTCTGCCAG	0.642													0	0	0	0.00632	0	27	140										C	4927465	G	C	4927465	3	2	59	1	0	0	0	0	1	0	0	0	16889	933	33	1	3407	1	UBN1	16	4927465	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2786	4927465	85427288	351	17154			5	69		6	6	10431	N	G_C	6.89832e-07
PPL	5493	broad.mit.edu	37	chr16	4933975	4933975	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttgtggttctcttccctcaGaaagtctagttccttggatg	9	9	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4933975G>A	uc002cyd.1	-	22	4771	c.4681C>T	c.(4681-4683)CTG>TTG	p.L1561L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1561	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TCTTCCCTCAGAAAGTCTAGT	0.552													0	0	0	0.00245	0	13	65										A	4933975	G	A	4933975	2	1	59	1	0	0	0	0	0	0	0	1	12334	933	33	1		1	PPL	16	4933975	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6510	4933975	85420778	352	17155			5	69		6	6	10431	N	G_C	6.89832e-07
PPL	5493	broad.mit.edu	37	chr16	4934725	4934725	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctctgagagctttgccctcaGagacgccacctcctccttgg	9	16	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4934725G>A	uc002cyd.1	-	22	4021	c.3931C>T	c.(3931-3933)CTG>TTG	p.L1311L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1311	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TTTGCCCTCAGAGACGCCACC	0.557													0	0	0	0.00632	0	24	92										A	4934725	G	A	4934725	2	1	59	1	0	0	0	0	0	0	0	1	12334	933	33	1		1	PPL	16	4934725	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	750	4934725	85420028	353	17156			5	69		6	6	10431	N	G_C	6.89832e-07
PPL	5493	broad.mit.edu	37	chr16	4934737	4934737	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgccctcagagacgccacctCctccttggtttgagggtctt	10	14	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4934737C>A	uc002cyd.1	-	22	4009	c.3919G>T	c.(3919-3921)GAG>TAG	p.E1307*		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1307	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GACGCCACCTCCTCCTTGGTT	0.537													1	0	6.94344e-10	0.006122	7.35108e-10	18	86										A	4934737	C	A	4934737	4	1	59	1	0	0	0	0	0	1	0	0	12334	864	30	3	1355	3	PPL	16	4934737	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	12	4934737	85420016	354	17157			5	69		6	6	10431	N	G_C	6.89832e-07
C16orf72	29035	broad.mit.edu	37	chr16	9210534	9210534	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttcttcctaggtcttagtgGtgcaatggctagtataagcg	11	8	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:9210534G>A	uc002czm.2	+	4	958	c.593G>A	c.(592-594)GGT>GAT	p.G198D		NM_014117	NP_054836	Q14CZ0	CP072_HUMAN	hypothetical protein LOC29035	198										large_intestine(1)	1						GGTCTTAGTGGTGCAATGGCT	0.428													0	0	0	0.01441	0	404	92										A	9210534	G	A	9210534	3	1	59	1	0	0	0	0	1	0	0	0	1831	1261	44	2	607	2	C16orf72	16	9210534	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4275797	9210534	81144219	355	17158										
MYH11	4629	broad.mit.edu	37	chr16	15809038	15809038	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tacctgctccttgtactgctCggccatcttgcgctcgtcct	8	16	1	0	rs148743922	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:15809038C>T	uc002ddy.2	-	39	5703	c.5596G>A	c.(5596-5598)GAG>AAG	p.E1866K	MYH11_uc002ddv.2_Missense_Mutation_p.E1873K|MYH11_uc002ddw.2_Missense_Mutation_p.E1866K|MYH11_uc002ddx.2_Missense_Mutation_p.E1873K|MYH11_uc010bvg.2_Missense_Mutation_p.E1698K|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.E572K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1866	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TTGTACTGCTCGGCCATCTTG	0.622			T	CBFB	AML								0	0	0	0.003163	0	13	97										T	15809038	C	T	15809038	3	4	59	1	0	0	0	0	1	0	0	0	10031	893	31	1	369	1	MYH11	16	15809038	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6598504	15809038	74545715	356	17159										
ABCC1	4363	broad.mit.edu	37	chr16	16110412	16110412	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtctacttttccctcttactCattcagctcgtcttgtcctg	5	14	5	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:16110412C>T	uc010bvi.2	+	5	724	c.549C>T	c.(547-549)CTC>CTT	p.L183L	ABCC1_uc010bvj.2_Silent_p.L183L|ABCC1_uc010bvk.2_Silent_p.L183L|ABCC1_uc010bvl.2_Silent_p.L183L|ABCC1_uc010bvm.2_Silent_p.L183L|ABCC1_uc002del.3_Silent_p.L67L|ABCC1_uc010bvn.2_Silent_p.L46L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	183	Helical; Name=5.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCCTCTTACTCATTCAGCTCG	0.493													0	0	0	0.01441	0	53	276										T	16110412	C	T	16110412	2	4	59	1	0	0	0	0	0	0	0	1	49	813	29	1		1	ABCC1	16	16110412	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	301374	16110412	74244341	357	17160										
ABCC1	4363	broad.mit.edu	37	chr16	16138333	16138333	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggtgaaggttgtgtactcctCcaaggatcctgcccagccga	12	12	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:16138333C>T	uc010bvi.2	+	8	1011	c.836C>T	c.(835-837)TCC>TTC	p.S279F	ABCC1_uc010bvj.2_Missense_Mutation_p.S279F|ABCC1_uc010bvk.2_Missense_Mutation_p.S279F|ABCC1_uc010bvl.2_Missense_Mutation_p.S279F|ABCC1_uc010bvm.2_Missense_Mutation_p.S279F|ABCC1_uc002del.3_Missense_Mutation_p.S163F|ABCC1_uc010bvn.2_Missense_Mutation_p.S142F	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	279	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTGTACTCCTCCAAGGATCCT	0.587													0	0	0	0.010729	0	10	49										T	16138333	C	T	16138333	3	4	59	1	0	0	0	0	1	0	0	0	49	855	30	1	866	1	ABCC1	16	16138333	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	27921	16138333	74216420	358	17161										
SMG1	23049	broad.mit.edu	37	chr16	18853033	18853033	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcatggaaccggggtgtttCttggcgattaattgtagcaa	13	6	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:18853033C>T	uc002dfm.2	-	41	6913	c.6550G>A	c.(6550-6552)GAA>AAA	p.E2184K	SMG1_uc010bwb.2_Missense_Mutation_p.E2044K|SMG1_uc010bwa.2_Missense_Mutation_p.E915K|SMG1_uc002dfo.3_Missense_Mutation_p.E482K	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2184	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CGGGGTGTTTCTTGGCGATTA	0.413													0	0	0	0.01441	0	115	164										T	18853033	C	T	18853033	3	4	59	1	0	0	0	0	1	0	0	0	14795	922	32	1	4527	1	SMG1	16	18853033	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2714700	18853033	71501720	359	17162										
DNAH3	55567	broad.mit.edu	37	chr16	21082053	21082053	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggcattctgcttctattggtTtgatgaatggggagccacac	12	8	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:21082053T>A	uc010vbe.1	-	22	3179	c.3179A>T	c.(3178-3180)AAA>ATA	p.K1060I		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1060	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTCTATTGGTTTGATGAATGG	0.433													0	0	0	0.00333	0	24	148										A	21082053	T	A	21082053	3	1	59	1	0	0	0	0	1	0	0	0	4603	1841	64	5	9334	5	DNAH3	16	21082053	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	2229020	21082053	69272700	360	17163										
IL21R	50615	broad.mit.edu	37	chr16	27460069	27460069	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcccagaactcggggggctCagcttacagtgaggagaggg	17	9	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:27460069C>G	uc002doq.1	+	9	1315	c.1082C>G	c.(1081-1083)TCA>TGA	p.S361*	IL21R_uc002dor.1_Nonsense_Mutation_p.S361*|IL21R_uc002dos.1_Nonsense_Mutation_p.S361*|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	361	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						TCGGGGGGCTCAGCTTACAGT	0.617			T	BCL6	NHL								0	0	0	0.007413	0	13	64										G	27460069	C	G	27460069	4	3	59	1	0	0	0	0	0	1	0	0	7671	838	29	1	1112	1	IL21R	16	27460069	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	6378016	27460069	62894684	361	17164										
HIRIP3	8479	broad.mit.edu	37	chr16	30005479	30005479	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcgtcctcgctgcttccactCaacctcttcccacccttaag	4	19	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:30005479C>T	uc002dve.2	-	4	1448	c.987G>A	c.(985-987)TTG>TTA	p.L329L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvg.1_5'Flank|INO80E_uc002dvh.1_5'Flank|INO80E_uc002dvi.1_5'Flank|INO80E_uc002dvj.1_5'Flank|INO80E_uc002dvk.1_5'Flank|HIRIP3_uc002dvf.2_Intron	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	329					chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						TGCTTCCACTCAACCTCTTCC	0.572													0	0	0	0.009535	0	27	80										T	30005479	C	T	30005479	2	4	59	1	0	0	0	0	0	0	0	1	7121	825	29	1		1	HIRIP3	16	30005479	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2545410	30005479	60349274	362	17165										
MYLPF	29895	broad.mit.edu	37	chr16	30388008	30388008	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cctgagggaaagggcaccatCaagaagaagttgtaagcatc	12	8	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:30388008C>G	uc002dxv.1	+	5	401	c.345C>G	c.(343-345)ATC>ATG	p.I115M		NM_013292	NP_037424	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast	115	EF-hand 2.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle				0			Colorectal(24;0.193)			AGGGCACCATCAAGAAGAAGT	0.567													0	0	0	0.004672	0	3	19										G	30388008	C	G	30388008	3	3	59	1	0	0	0	0	1	0	0	0	10060	816	29	1	363	1	MYLPF	16	30388008	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	382529	30388008	59966745	363	17166										
SRCAP	10847	broad.mit.edu	37	chr16	30749040	30749040	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtgtgcccaggcattggcatCtccagagtccctggagctgg	14	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:30749040C>G	uc002dze.1	+	34	8064	c.7679C>G	c.(7678-7680)TCT>TGT	p.S2560C	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.S2355C	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2560	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCATTGGCATCTCCAGAGTCC	0.562													0	0	0	0.00499	0	17	43										G	30749040	C	G	30749040	3	3	59	1	0	0	0	0	1	0	0	0	15134	913	32	1	7805	1	SRCAP	16	30749040	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	361032	30749040	59605713	364	17167										
RSPRY1	89970	broad.mit.edu	37	chr16	57250818	57250818	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttatgtctttccaaacaggtGaaaataaattgactatttct	5	6	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57250818G>T	uc002elb.2	+	8	1050	c.772G>T	c.(772-774)GAA>TAA	p.E258*	RSPRY1_uc002elc.2_Nonsense_Mutation_p.E258*|RSPRY1_uc002eld.2_Nonsense_Mutation_p.E258*	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	258						extracellular region	zinc ion binding			ovary(1)	1						CCAAACAGGTGAAAATAAATT	0.378													1	0	8.00594e-06	0.007413	8.32926e-06	16	78										T	57250818	G	T	57250818	4	4	59	1	0	0	0	0	0	1	0	0	13713	1291	45	3	798	3	RSPRY1	16	57250818	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	26501778	57250818	33103935	365	17168										
DOK4	55715	broad.mit.edu	37	chr16	57508744	57508744	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcgtgtggcatcccggccaTagcggcgcagtgagcagagg	17	11	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57508744T>C	uc010cdb.2	-	5	858	c.560A>G	c.(559-561)TAT>TGT	p.Y187C	DOK4_uc002elu.1_Missense_Mutation_p.Y187C|DOK4_uc002elv.3_Missense_Mutation_p.Y187C	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	187	IRS-type PTB.						insulin receptor binding			skin(1)	1						ATCCCGGCCATAGCGGCGCAG	0.597													0	0	0	0.004007	0	12	35										C	57508744	T	C	57508744	3	2	59	1	0	0	0	0	1	0	0	0	4699	1406	49	5	436	5	DOK4	16	57508744	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	257926	57508744	32846009	366	17169										
KATNB1	10300	broad.mit.edu	37	chr16	57789144	57789144	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggctgaaggcctccgacttCctgcccgtgagtaggagccc	14	14	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57789144C>T	uc002eml.1	+	15	1784	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	470	Interaction with KATNA1 and NDEL1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CCTCCGACTTCCTGCCCGTGA	0.662													0	0	0	0.014758	0	3	13										T	57789144	C	T	57789144	2	4	59	1	0	0	0	0	0	0	0	1	7987	854	30	1		1	KATNB1	16	57789144	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	280400	57789144	32565609	367	17170										
KATNB1	10300	broad.mit.edu	37	chr16	57789809	57789809	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcggtggtggtggacctcctGaacatcgtcaaccagaaagc	12	11	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57789809G>C	uc002eml.1	+	17	1997	c.1623G>C	c.(1621-1623)CTG>CTC	p.L541L		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	541	Interaction with KATNA1 and NDEL1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				TGGACCTCCTGAACATCGTCA	0.557													0	0	0	0.012319	0	17	40										C	57789809	G	C	57789809	2	2	59	1	0	0	0	0	0	0	0	1	7987	1277	45	1		1	KATNB1	16	57789809	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	665	57789809	32564944	368	17171										
TMCO7	79613	broad.mit.edu	37	chr16	68909058	68909058	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tctctctccattgtgccagcGggagcagctggtggaagtga	14	10	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:68909058G>A	uc002ewi.3	+	5	1008	c.996G>A	c.(994-996)GCG>GCA	p.A332A		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	332						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TTGTGCCAGCGGGAGCAGCTG	0.468													0	0	0	0.014323	0	17	50										A	68909058	G	A	68909058	2	1	59	1	0	0	0	0	0	0	0	1	15998	1130	39	2		2	TMCO7	16	68909058	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	11119249	68909058	21445695	369	17172										
HYDIN	54768	broad.mit.edu	37	chr16	70942755	70942755	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttagatgagctggtctgctCctcttgagccttaattaaaa	8	9	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:70942755C>G	uc002ezr.2	-	48	8139	c.8011G>C	c.(8011-8013)GAG>CAG	p.E2671Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2672										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTGGTCTGCTCCTCTTGAGCC	0.423													0	0	0	0.012319	0	19	35										G	70942755	C	G	70942755	3	3	59	1	0	0	0	0	1	0	0	0	7467	864	30	1	7507	1	HYDIN	16	70942755	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2033697	70942755	19411998	370	17173										
ADAMTS18	170692	broad.mit.edu	37	chr16	77325218	77325218	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgttgtacactggatgggctGggcaagcccgtcggttgcag	16	9	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:77325218G>C	uc002ffc.3	-	21	3766	c.3347C>G	c.(3346-3348)CCA>CGA	p.P1116R		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1116	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGGATGGGCTGGGCAAGCCCG	0.512													0	0	0	0.007413	0	17	87										C	77325218	G	C	77325218	3	2	59	1	0	0	0	0	1	0	0	0	263	1348	47	4	330	4	ADAMTS18	16	77325218	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6382463	77325218	13029535	371	17174										
ADAMTS18	170692	broad.mit.edu	37	chr16	77328882	77328882	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctgttgcaggcttggacctGagtgggtgtgctcactggac	16	9	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:77328882G>C	uc002ffc.3	-	19	3363	c.2944C>G	c.(2944-2946)CAG>GAG	p.Q982E	ADAMTS18_uc010chc.1_Missense_Mutation_p.Q570E	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	982	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GCTTGGACCTGAGTGGGTGTG	0.542													0	0	0	0.00245	0	13	22										C	77328882	G	C	77328882	3	2	59	1	0	0	0	0	1	0	0	0	263	1299	45	1	741	1	ADAMTS18	16	77328882	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3664	77328882	13025871	372	17175										
MBTPS1	8720	broad.mit.edu	37	chr16	84135328	84135328	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttttccagtctgtcgcccaGatgtttcttcccacagagca	7	14	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:84135328G>C	uc002fhi.2	-	2	563	c.61C>G	c.(61-63)CTG>GTG	p.L21V		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	21					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CTGTCGCCCAGATGTTTCTTC	0.438													0	0	0	0.01441	0	39	81										C	84135328	G	C	84135328	3	2	59	1	0	0	0	0	1	0	0	0	9361	933	33	1	3185	1	MBTPS1	16	84135328	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	6806446	84135328	6219425	373	17176										
KCNG4	93107	broad.mit.edu	37	chr16	84256463	84256463	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagacaccgccagcgacacgTagtatggggagatggccagg	15	11	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:84256463T>C	uc010voc.1	-	3	1041	c.920A>G	c.(919-921)TAC>TGC	p.Y307C		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	307	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CAGCGACACGTAGTATGGGGA	0.637													0	0	0	0.014758	0	4	15										C	84256463	T	C	84256463	3	2	59	1	0	0	0	0	1	0	0	0	8030	1638	57	5	641	5	KCNG4	16	84256463	Missense_Mutation	SNP	T	TCGA-DK-A3IN-01A-11D-A20D-08	121135	84256463	6098290	374	17177										
C16orf7	9605	broad.mit.edu	37	chr16	89777137	89777137	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agctgtccttgtctggcaatCcagatgcggtgtcccccagg	12	13	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:89777137C>G	uc002fom.1	-	10	1240	c.1115G>C	c.(1114-1116)GGA>GCA	p.G372A	C16orf7_uc002fol.1_Missense_Mutation_p.G302A|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	372					ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GTCTGGCAATCCAGATGCGGT	0.726													0	0	0	0.004672	0	2	6										G	89777137	C	G	89777137	3	3	59	1	0	0	0	0	1	0	0	0	1828	855	30	1	804	1	C16orf7	16	89777137	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5520674	89777137	577616	375	17178										
ZNF594	84622	broad.mit.edu	37	chr17	5086808	5086808	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ataagatctgtgctttgactGaaagccttcccacatttatt	6	9	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:5086808G>T	uc010cla.1	-	2	900	c.744C>A	c.(742-744)TTC>TTA	p.F248L		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	248	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TGCTTTGACTGAAAGCCTTCC	0.428													1	0	8.87156e-34	0.01441	9.59903e-34	72	84										T	5086808	G	T	5086808	3	4	59	1	0	0	0	0	1	0	0	0	18021	1281	45	3	1683	3	ZNF594	17	5086808	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		5086808	76108402	376	17179										
TP53	7157	broad.mit.edu	37	chr17	7578239	7578239	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtttctgtcatccaaatactCcacacgcaaatttccttcca	3	14	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:7578239C>G	uc002gim.2	-	6	804	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	TP53_uc002gig.1_Missense_Mutation_p.E204Q|TP53_uc002gih.2_Missense_Mutation_p.E204Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E72Q|TP53_uc010cng.1_Missense_Mutation_p.E72Q|TP53_uc002gii.1_Missense_Mutation_p.E72Q|TP53_uc010cnh.1_Missense_Mutation_p.E204Q|TP53_uc010cni.1_Missense_Mutation_p.E204Q|TP53_uc002gij.2_Missense_Mutation_p.E204Q|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.E111Q|TP53_uc002gio.2_Missense_Mutation_p.E72Q|TP53_uc010vug.1_Missense_Mutation_p.E165Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	204	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> A (in sporadic cancers; somatic mutation).|VE -> LV (in a sporadic cancer; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E204*(23)|p.0?(7)|p.E204fs*5(3)|p.E204G(2)|p.E204E(2)|p.E204K(2)|p.E204fs*43(2)|p.K164_P219del(1)|p.E204Q(1)|p.E204D(1)|p.E204fs*4(1)|p.E204A(1)|p.V203_E204>V*(1)|p.E204V(1)|p.V203_E204>LV(1)|p.E204fs*39(1)|p.G199fs*42(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCAAATACTCCACACGCAAA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.003954	0	21	39										G	7578239	C	G	7578239	3	3	59	1	0	0	0	0	1	0	0	0	16378	864	30	1	684	1	TP53	17	7578239	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2491431	7578239	73616971	377	17180			6	70		3	3	296	C		9.755731e-06
TP53	7157	broad.mit.edu	37	chr17	7578488	7578488	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccgggcgggggtgtggaatCaacccacagctgcacagggc	17	12	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:7578488C>T	uc002gim.2	-	5	636	c.442G>A	c.(442-444)GAT>AAT	p.D148N	TP53_uc002gig.1_Missense_Mutation_p.D148N|TP53_uc002gih.2_Missense_Mutation_p.D148N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D16N|TP53_uc010cng.1_Missense_Mutation_p.D16N|TP53_uc002gii.1_Missense_Mutation_p.D16N|TP53_uc010cnh.1_Missense_Mutation_p.D148N|TP53_uc010cni.1_Missense_Mutation_p.D148N|TP53_uc002gij.2_Missense_Mutation_p.D148N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.D55N|TP53_uc002gio.2_Missense_Mutation_p.D16N|TP53_uc010vug.1_Missense_Mutation_p.D109N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	148	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> N (in sporadic cancers; somatic mutation).|D -> A (in a sporadic cancer; somatic mutation).|D -> V (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> Y (in sporadic cancers; somatic mutation).|D -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.D148E(4)|p.D148N(4)|p.D148V(2)|p.D148fs*23(2)|p.D148fs*22(2)|p.D148fs*33(2)|p.D148_T155delDSTPPPGT(1)|p.Q144_G154del11(1)|p.W146_S149>C(1)|p.D148del(1)|p.Q144fs*32(1)|p.D148Y(1)|p.D148fs*34(1)|p.D148fs*32(1)|p.D148D(1)|p.D148*(1)|p.D148H(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGTGGAATCAACCCACAGC	0.602		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006999	0	36	32										T	7578488	C	T	7578488	3	4	59	1	0	0	0	0	1	0	0	0	16378	826	29	1	856	1	TP53	17	7578488	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	249	7578488	73616722	378	17181			6	70		3	3	296	C		9.755731e-06
TP53	7157	broad.mit.edu	37	chr17	7578534	7578534	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttggccagttggcaaaacatCttgttgagggcaggggagta	15	6	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:7578534C>G	uc002gim.2	-	5	590	c.396G>C	c.(394-396)AAG>AAC	p.K132N	TP53_uc002gig.1_Missense_Mutation_p.K132N|TP53_uc002gih.2_Missense_Mutation_p.K132N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132N|TP53_uc010cni.1_Missense_Mutation_p.K132N|TP53_uc002gij.2_Missense_Mutation_p.K132N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39N|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.M133fs*16(1)|p.V73fs*9(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.010504	0	19	24										G	7578534	C	G	7578534	3	3	59	1	0	0	0	0	1	0	0	0	16378	912	32	1	902	1	TP53	17	7578534	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	46	7578534	73616676	379	17182			6	70		3	3	296	C		9.755731e-06
CDRT1	374286	broad.mit.edu	37	chr17	15522810	15522810	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agggggcattcttgagccttGattccaggttttccatgatc	11	9	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:15522810G>C	uc002gov.3	-	1	209	c.17C>G	c.(16-18)TCA>TGA	p.S6*	TRIM16_uc002gor.1_Intron	NM_006382	NP_006373	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	6											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		CTTGAGCCTTGATTCCAGGTT	0.498													0	0	0	0.01441	0	110	219										C	15522810	G	C	15522810	4	2	59	1	0	0	0	0	0	1	0	0	3174	1294	45	1	2289	1	CDRT1	17	15522810	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7944276	15522810	65672400	380	17183										
KIAA0100	9703	broad.mit.edu	37	chr17	26950907	26950907	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcaccataccaggctggatgGtgctggcactgcagcagttg	13	11	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:26950907G>T	uc002hbu.2	-	26	4929	c.4830C>A	c.(4828-4830)CAC>CAA	p.H1610Q	KIAA0100_uc002hbt.2_5'Flank	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1610						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGGCTGGATGGTGCTGGCACT	0.522													1	0	0.000274275	0.004482	0.000282634	8	173										T	26950907	G	T	26950907	3	4	59	1	0	0	0	0	1	0	0	0	8154	1252	44	4	1933	4	KIAA0100	17	26950907	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	11428097	26950907	54244303	381	17184										
MYO18A	399687	broad.mit.edu	37	chr17	27413464	27413464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gccacttctcacctgttgatGaggtcctcattctcatcact	6	14	4	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:27413464G>A	uc002hdt.1	-	39	6002	c.5844C>T	c.(5842-5844)CTC>CTT	p.L1948L	MYO18A_uc010wbc.1_Silent_p.L1481L|MYO18A_uc002hds.2_Silent_p.L1490L|MYO18A_uc010csa.1_Silent_p.L1911L|MYO18A_uc002hdu.1_Silent_p.L1948L	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1948	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACCTGTTGATGAGGTCCTCAT	0.562													0	0	0	0.014758	0	3	7										A	27413464	G	A	27413464	2	1	59	1	0	0	0	0	0	0	0	1	10065	1277	45	1		1	MYO18A	17	27413464	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	462557	27413464	53781746	382	17185										
CCL1	6346	broad.mit.edu	37	chr17	32688819	32688819	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttacattaagccctcattgGagcagatggagctggtattt	10	8	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:32688819G>C	uc002hid.1	-	2	245	c.173C>G	c.(172-174)TCC>TGC	p.S58C		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	58					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GCCCTCATTGGAGCAGATGGA	0.483											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	57	128										C	32688819	G	C	32688819	3	2	59	1	0	0	0	0	1	0	0	0	2882	1174	41	1	125	1	CCL1	17	32688819	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5275355	32688819	48506391	383	17186										
CCL1	6346	broad.mit.edu	37	chr17	32688887	32688887	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atctcttgctccgcaaatgaGaagcaacatctggagaaggg	11	9	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:32688887G>C	uc002hid.1	-	2	177	c.105C>G	c.(103-105)TTC>TTG	p.F35L		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	35					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		CCGCAAATGAGAAGCAACATC	0.453											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	28	77										C	32688887	G	C	32688887	3	2	59	1	0	0	0	0	1	0	0	0	2882	933	33	1	193	1	CCL1	17	32688887	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	68	32688887	48506323	384	17187										
SLFN12L	342615	broad.mit.edu	37	chr17	33807129	33807129	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtgactcttcccacatttaGaaccagctcagcatagtttg	7	11	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:33807129G>A	uc002hjn.2	-	3	1066	c.187C>T	c.(187-189)CTA>TTA	p.L63L		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						CCCACATTTAGAACCAGCTCA	0.388													0	0	0	0.006214	0	9	30										A	33807129	G	A	33807129	2	1	59	1	0	0	0	0	0	0	0	1	14735	933	33	1		1	SLFN12L	17	33807129	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1118242	33807129	47388081	385	17188										
MED24	9862	broad.mit.edu	37	chr17	38178927	38178927	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcagtgcccggggggtccatGaggctgtgccacttggagga	18	10	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:38178927G>C	uc002htt.2	-	21	2716	c.2403C>G	c.(2401-2403)CTC>CTG	p.L801L	MED24_uc010weq.1_5'Flank|MED24_uc002htr.2_5'Flank|MED24_uc010wer.1_Silent_p.L136L|MED24_uc010wes.1_Silent_p.L661L|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Silent_p.L826L|MED24_uc002htu.2_Silent_p.L788L|MED24_uc010cwn.2_Silent_p.L788L|MED24_uc010weu.1_Silent_p.L711L|MED24_uc010wev.1_Silent_p.L751L	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	801					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					GGGGGTCCATGAGGCTGTGCC	0.617													0	0	0	0.007413	0	14	24										C	38178927	G	C	38178927	2	2	59	1	0	0	0	0	0	0	0	1	9442	1277	45	1		1	MED24	17	38178927	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4371798	38178927	43016283	386	17189										
TOP2A	7153	broad.mit.edu	37	chr17	38563833	38563833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aatcattatcttcccataacGaagcgtcttcaatgaatctt	4	10	5	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:38563833G>A	uc002huq.2	-	13	1720	c.1594C>T	c.(1594-1596)CGT>TGT	p.R532C		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	532					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTCCCATAACGAAGCGTCTTC	0.294													0	0	0	0.004482	0	7	14										A	38563833	G	A	38563833	3	1	59	1	0	0	0	0	1	0	0	0	16362	1058	37	1	3093	1	TOP2A	17	38563833	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	384906	38563833	42631377	387	17190										
KRTAP9-8	83901	broad.mit.edu	37	chr17	39394331	39394331	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actgttgttccccttgctgtCagcctacgtgctgcaggacc	10	14	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:39394331C>T	uc002hwh.3	+	1	62	c.28C>T	c.(28-30)CAG>TAG	p.Q10*	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	10	1.|15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCCTTGCTGTCAGCCTACGTG	0.592													0	0	0	0.003954	0	22	133										T	39394331	C	T	39394331	4	4	59	1	0	0	0	0	0	1	0	0	8576	827	29	1	30	1	KRTAP9-8	17	39394331	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	830498	39394331	41800879	388	17191										
KLHL11	55175	broad.mit.edu	37	chr17	40021195	40021195	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcgggccccggctcggagctCcacttgcgcatctccacccg	11	19	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:40021195C>T	uc002hyf.1	-	1	435	c.429G>A	c.(427-429)TGG>TGA	p.W143*		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	143	BTB.					extracellular region					0		Breast(137;0.00156)				GCTCGGAGCTCCACTTGCGCA	0.677													0	0	0	0.005443	0	23	40										T	40021195	C	T	40021195	4	4	59	1	0	0	0	0	0	1	0	0	8367	856	30	1	1705	1	KLHL11	17	40021195	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	626864	40021195	41174015	389	17192										
BRCA1	672	broad.mit.edu	37	chr17	41246522	41246522	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcacacaggggatcagcattCagatctacctttttttctgt	7	10	5	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:41246522C>G	uc002icq.2	-	10	1258	c.1026G>C	c.(1024-1026)CTG>CTC	p.L342L	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Silent_p.L271L|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Silent_p.L295L|BRCA1_uc002ict.2_Silent_p.L342L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Silent_p.L342L|BRCA1_uc002ide.1_Silent_p.L173L|BRCA1_uc010cyy.1_Silent_p.L342L|BRCA1_uc010whs.1_Silent_p.L342L|BRCA1_uc010cyz.2_Silent_p.L295L|BRCA1_uc010cza.2_Silent_p.L316L|BRCA1_uc010wht.1_Silent_p.L46L	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	342					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GATCAGCATTCAGATCTACCT	0.438			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	0.008361	0	28	161										G	41246522	C	G	41246522	2	3	59	1	0	0	0	0	0	0	0	1	1498	813	29	1		1	BRCA1	17	41246522	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1225327	41246522	39948688	390	17193										
CCDC43	124808	broad.mit.edu	37	chr17	42759437	42759437	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttctctgcttctcctcttctGacaccatccttggctttact	4	15	4	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:42759437G>C	uc002ihc.2	-	3	406	c.362C>G	c.(361-363)TCA>TGA	p.S121*	CCDC43_uc010czw.1_Nonsense_Mutation_p.S121*	NM_144609	NP_653210	Q96MW1	CCD43_HUMAN	coiled-coil domain containing 43 isoform 1	121	Potential.										0		Prostate(33;0.0322)				CTCCTCTTCTGACACCATCCT	0.498													0	0	0	0.00333	0	24	103										C	42759437	G	C	42759437	4	2	59	1	0	0	0	0	0	1	0	0	2815	1294	45	1	324	1	CCDC43	17	42759437	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1512915	42759437	38435773	391	17194										
LRRC37A2	474170	broad.mit.edu	37	chr17	44630810	44630810	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caagaagatgaagaaggattCtcaaggtaaatattagtctg	10	4	2	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:44630810C>T	uc002ikn.1	+	11	4857	c.4854C>T	c.(4852-4854)TTC>TTT	p.F1618F	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Silent_p.F579F|ARL17A_uc002iks.2_3'UTR	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1618	Cytoplasmic (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AAGAAGGATTCTCAAGGTAAA	0.224													0	0	0	0.00632	0	21	155										T	44630810	C	T	44630810	2	4	59	1	0	0	0	0	0	0	0	1	8992	912	32	1		1	LRRC37A2	17	44630810	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1871373	44630810	36564400	392	17195										
MYCBPAP	84073	broad.mit.edu	37	chr17	48596430	48596430	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agctcattgactgcacacttCcaacccggcgtgataggaaa	9	12	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:48596430C>A	uc010wmr.1	+	6	1039	c.877C>A	c.(877-879)CCA>ACA	p.P293T	MYCBPAP_uc002iqx.2_Missense_Mutation_p.P293T|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	256					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CTGCACACTTCCAACCCGGCG	0.617													1	0	0.00198382	0.001984	0.00204039	5	52										A	48596430	C	A	48596430	3	1	59	1	0	0	0	0	1	0	0	0	10019	855	30	3	899	3	MYCBPAP	17	48596430	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3965620	48596430	32598780	393	17196										
ACE	1636	broad.mit.edu	37	chr17	61564428	61564428	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atggcagctgcctgcagctcGagccaggtgagagctcatgt	14	11	1	1	rs148995315		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:61564428G>C	uc002jau.1	+	15	2321	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	ACE_uc002jav.1_Missense_Mutation_p.E193Q|ACE_uc010ddv.1_5'UTR|ACE_uc010wpj.1_Missense_Mutation_p.E193Q|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.E77Q	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	767	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCTGCAGCTCGAGCCAGGTGA	0.617													0	0	0	0.008871	0	20	42										C	61564428	G	C	61564428	3	2	59	1	0	0	0	0	1	0	0	0	136	1059	37	1	2560	1	ACE	17	61564428	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	12967998	61564428	19630782	394	17197										
DDX5	1655	broad.mit.edu	37	chr17	62499953	62499953	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gcctctctctaggaatggctGatgattgatgtggacaatgg	13	7	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:62499953G>A	uc002jek.2	-	5	722	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	DDX5_uc010deh.2_Nonsense_Mutation_p.Q159*|DDX5_uc002jej.2_Nonsense_Mutation_p.Q54*|DDX5_uc010wqa.1_Intron|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	159	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGGAATGGCTGATGATTGATG	0.333			T	ETV4	prostate								0	0	0	0.00499	0	13	64										A	62499953	G	A	62499953	4	1	59	1	0	0	0	0	0	1	0	0	4367	1299	45	1	1405	1	DDX5	17	62499953	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	935525	62499953	18695257	395	17198										
ABCA5	23461	broad.mit.edu	37	chr17	67273900	67273900	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agcagccttggtttcagaaaGaataagtaagctctgttcca	9	8	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:67273900G>C	uc002jif.2	-	18	3694	c.2476C>G	c.(2476-2478)CTT>GTT	p.L826V	ABCA5_uc002jic.2_Missense_Mutation_p.L49V|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.L826V|ABCA5_uc002jih.2_Missense_Mutation_p.L826V|ABCA5_uc010dfe.2_Missense_Mutation_p.L826V	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	826					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GTTTCAGAAAGAATAAGTAAG	0.363													0	0	0	0.003163	0	13	23										C	67273900	G	C	67273900	3	2	59	1	0	0	0	0	1	0	0	0	35	942	33	1	2536	1	ABCA5	17	67273900	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4773947	67273900	13921310	396	17199										
DNAI2	64446	broad.mit.edu	37	chr17	72281227	72281227	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cccggggagttaaccatgtcGaggggggctggcccaaggac	17	11	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:72281227G>C	uc002jkf.2	+	3	331	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	78					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						TAACCATGTCGAGGGGGGCTG	0.562									Kartagener_syndrome				0	0	0	0.00308	0	5	68										C	72281227	G	C	72281227	3	2	59	1	0	0	0	0	1	0	0	0	4610	1059	37	1	238	1	DNAI2	17	72281227	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5007327	72281227	8913983	397	17200										
EVPL	2125	broad.mit.edu	37	chr17	74015086	74015086	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaggggccacatcccggcttCgccgctgcaggtccccagtg	14	16	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:74015086C>T	uc002jqi.2	-	11	1421	c.1193G>A	c.(1192-1194)CGA>CAA	p.R398Q	EVPL_uc010wss.1_Missense_Mutation_p.R398Q|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	398	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						ATCCCGGCTTCGCCGCTGCAG	0.672													0	0	0	0.001168	0	5	9										T	74015086	C	T	74015086	3	4	59	1	0	0	0	0	1	0	0	0	5292	884	31	1	4956	1	EVPL	17	74015086	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1733859	74015086	7180124	398	17201										
THOC1	9984	broad.mit.edu	37	chr18	226868	226868	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctgcaacaggatgtgtcgacGaaagttactgtcactcagtt	10	9	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:226868G>A	uc002kkj.3	-	12	992	c.952C>T	c.(952-954)CGT>TGT	p.R318C	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_Missense_Mutation_p.R318C|THOC1_uc002kkh.3_5'Flank	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	318					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				ATGTGTCGACGAAAGTTACTG	0.343													0	0	0	0.006122	0	13	8										A	226868	G	A	226868	3	1	59	1	0	0	0	0	1	0	0	0	15861	1058	37	1	1061	1	THOC1	18	226868	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		226868	77850380	399	17202										
RIOK3	8780	broad.mit.edu	37	chr18	21044494	21044494	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgcctttagcaaaaccggttCccactcctaaaaagggcttt	7	12	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:21044494C>G	uc002kui.3	+	5	1062	c.445C>G	c.(445-447)CCC>GCC	p.P149A	RIOK3_uc010dls.2_Missense_Mutation_p.P149A|RIOK3_uc010xas.1_Missense_Mutation_p.P133A|RIOK3_uc010xat.1_5'Flank	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	149					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAACCGGTTCCCACTCCTAA	0.363													0	0	0	0.004289	0	35	24										G	21044494	C	G	21044494	3	3	59	1	0	0	0	0	1	0	0	0	13379	855	30	1	463	1	RIOK3	18	21044494	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	20817626	21044494	57032754	400	17203										
KIAA1632	57724	broad.mit.edu	37	chr18	43496060	43496060	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caagtggtccatgaggaagaGgataggttgttctcggtacc	14	7	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:43496060G>A	uc002lbm.2	-	19	3596	c.3496C>T	c.(3496-3498)CTC>TTC	p.L1166F	KIAA1632_uc002lbo.1_Missense_Mutation_p.L1166F|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.L41F	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1166					autophagy						0						ATGAGGAAGAGGATAGGTTGT	0.468													0	0	0	0.001984	0	6	72										A	43496060	G	A	43496060	3	1	59	1	0	0	0	0	1	0	0	0	8249	1000	35	2	4347	2	KIAA1632	18	43496060	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	22451566	43496060	34581188	401	17204										
TCEB3B	51224	broad.mit.edu	37	chr18	44560549	44560549	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctcctccacctcagagagggAgctcacggacgttctgtcca	10	15	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:44560549A>T	uc002lcr.1	-	1	1440	c.1087T>A	c.(1087-1089)TCC>ACC	p.S363T	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	363					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TCAGAGAGGGAGCTCACGGAC	0.542													0	0	0	0.006214	0	9	88										T	44560549	A	T	44560549	3	4	59	1	0	0	0	0	1	0	0	0	15679	304	11	5	1178	5	TCEB3B	18	44560549	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	1064489	44560549	33516699	402	17205										
ATP8B3	148229	broad.mit.edu	37	chr19	1783250	1783250	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgaaaatctcctcgctggggCcctcctccaccttctcctcc	6	19	2	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:1783250C>T	uc002ltw.2	-	29	3914	c.3680G>A	c.(3679-3681)GGC>GAC	p.G1227D	ATP8B3_uc002ltv.2_Missense_Mutation_p.G1190D|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1227	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCGCTGGGGCCCTCCTCCAC	0.592													0	0	0	0.009096	0	3	5										T	1783250	C	T	1783250	3	4	59	1	0	0	0	0	1	0	0	0	1196	739	26	2	226	2	ATP8B3	19	1783250	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		1783250	57345733	403	17206										
TMEM146	257062	broad.mit.edu	37	chr19	5745953	5745953	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aagtactcagatcaccccctCaaccggagtttcgggctgtc	9	14	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:5745953C>A	uc002mda.2	+	9	748	c.687C>A	c.(685-687)CTC>CTA	p.L229L	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	229	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATCACCCCCTCAACCGGAGTT	0.498													1	0	3.16549e-35	0.01441	3.43192e-35	83	147										A	5745953	C	A	5745953	2	1	59	1	0	0	0	0	0	0	0	1	16057	813	29	3		3	TMEM146	19	5745953	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3962703	5745953	53383030	404	17207										
FUT3	2525	broad.mit.edu	37	chr19	5844334	5844334	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aggctggccggaccacggctCcagccagccgtagggcgtga	16	14	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:5844334C>T	uc002mdk.2	-	2	614	c.517G>A	c.(517-519)GAG>AAG	p.E173K	FUT3_uc002mdm.2_Missense_Mutation_p.E173K|FUT3_uc002mdj.2_Missense_Mutation_p.E173K|FUT3_uc002mdl.2_Missense_Mutation_p.E173K	NM_001097641	NP_001091110	P21217	FUT3_HUMAN	fucosyltransferase 3	173	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity				0						GACCACGGCTCCAGCCAGCCG	0.647													0	0	0	0.007413	0	14	28										T	5844334	C	T	5844334	3	4	59	1	0	0	0	0	1	0	0	0	6105	864	30	1	572	1	FUT3	19	5844334	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	98381	5844334	53284649	405	17208										
RANBP3	8498	broad.mit.edu	37	chr19	5941640	5941640	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgcatattttacctgactgtGagggtgggaactgggttaaa	13	5	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:5941640G>C	uc002mdw.2	-	5	625	c.398C>G	c.(397-399)TCA>TGA	p.S133*	RANBP3_uc002mdx.2_Nonsense_Mutation_p.S133*|RANBP3_uc002mdy.2_Nonsense_Mutation_p.S65*|RANBP3_uc002mdz.2_Nonsense_Mutation_p.S65*|RANBP3_uc010duq.2_5'UTR|RANBP3_uc002mea.2_Intron|RANBP3_uc010xix.1_Intron	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	133					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						ACCTGACTGTGAGGGTGGGAA	0.468													0	0	0	0.01441	0	37	57										C	5941640	G	C	5941640	4	2	59	1	0	0	0	0	0	1	0	0	13029	1294	45	1	1357	1	RANBP3	19	5941640	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	97306	5941640	53187343	406	17209										
GTF2F1	2962	broad.mit.edu	37	chr19	6389529	6389529	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aactccttgaggacgatgccGtacttcttcctccgagcctc	8	15	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:6389529G>A	uc002meq.2	-	4	537	c.252C>T	c.(250-252)TAC>TAT	p.Y84Y	GTF2F1_uc010xjb.1_5'Flank|GTF2F1_uc010xjc.1_Silent_p.Y56Y	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	84					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GGACGATGCCGTACTTCTTCC	0.617													0	0	0	0.014758	0	5	207										A	6389529	G	A	6389529	2	1	59	1	0	0	0	0	0	0	0	1	6858	1140	40	2		2	GTF2F1	19	6389529	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	447889	6389529	52739454	407	17210										
SNAPC2	6618	broad.mit.edu	37	chr19	7987050	7987050	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agaccccgcccctgaaatacCtagctctgcccctgctgcac	7	19	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:7987050C>T	uc002miw.1	+	4	526	c.503C>T	c.(502-504)CCT>CTT	p.P168L	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	168					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						CCTGAAATACCTAGCTCTGCC	0.642													0	0	0	0.013537	0	10	89										T	7987050	C	T	7987050	3	4	59	1	0	0	0	0	1	0	0	0	14835	681	24	2	517	2	SNAPC2	19	7987050	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1597521	7987050	51141933	408	17211										
TIMM44	10469	broad.mit.edu	37	chr19	7992547	7992547	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cactccctcactcaccgggtCaccctccaccacctcgcctt	4	23	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:7992547C>T	uc002miz.2	-	12	1236	c.1234G>A	c.(1234-1236)GAC>AAC	p.D412N	TIMM44_uc002mja.2_Missense_Mutation_p.D152N|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	412					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CTCACCGGGTCACCCTCCACC	0.632													0	0	0	0.004656	0	20	157										T	7992547	C	T	7992547	3	4	59	1	0	0	0	0	1	0	0	0	15909	826	29	1	132	1	TIMM44	19	7992547	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5497	7992547	51136436	409	17212										
MUC16	94025	broad.mit.edu	37	chr19	9001862	9001862	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gacagggaggctggagttctCgaggttgccaggtgcattgt	17	7	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:9001862C>G	uc002mkp.2	-	53	40590	c.40386G>C	c.(40384-40386)TCG>TCC	p.S13462S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.S279S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGAGTTCTCGAGGTTGCCA	0.488													0	0	0	0.010729	0	5	15										G	9001862	C	G	9001862	2	3	59	1	0	0	0	0	0	0	0	1	9973	871	31	1		1	MUC16	19	9001862	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1009315	9001862	50127121	410	17213										
ZNF136	7695	broad.mit.edu	37	chr19	12296680	12296680	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gatccttcccagaagaatctCtacagagatgtgatgtggga	11	8	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:12296680C>G	uc002mti.2	+	2	184	c.84C>G	c.(82-84)CTC>CTG	p.L28L	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	28	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						AGAAGAATCTCTACAGAGATG	0.443													0	0	0	0.007291	0	23	41										G	12296680	C	G	12296680	2	3	59	1	0	0	0	0	0	0	0	1	17723	900	32	1		1	ZNF136	19	12296680	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3294818	12296680	46832303	411	17214										
PRDX2	7001	broad.mit.edu	37	chr19	12911834	12911834	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aacgcgatgatctcggtgggGcacacaaaagtgaagtccag	13	9	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:12911834G>A	uc002mvd.2	-	3	303	c.153C>T	c.(151-153)TGC>TGT	p.C51C	PRDX2_uc002mve.1_Silent_p.C51C	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	51	Thioredoxin.	Cysteine sulfenic acid (-SOH) intermediate.			anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						TCTCGGTGGGGCACACAAAAG	0.587													0	0	0	0.001984	0	6	31										A	12911834	G	A	12911834	2	1	59	1	0	0	0	0	0	0	0	1	12465	1195	42	2		2	PRDX2	19	12911834	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	615154	12911834	46217149	412	17215										
CACNA1A	773	broad.mit.edu	37	chr19	13340984	13340984	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggagtctcgggtgaggtactCaaagttgtccatgatgacgg	15	7	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:13340984C>G	uc010dze.2	-	36	5679	c.5443G>C	c.(5443-5445)GAG>CAG	p.E1815Q	CACNA1A_uc010xnd.1_Missense_Mutation_p.E520Q|CACNA1A_uc002mwx.3_Missense_Mutation_p.E520Q|CACNA1A_uc010dzc.2_Missense_Mutation_p.E1340Q|CACNA1A_uc002mwy.3_Missense_Mutation_p.E1814Q|CACNA1A_uc002mwv.3_Missense_Mutation_p.E331Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1815	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GTGAGGTACTCAAAGTTGTCC	0.577													0	0	0	0.001168	0	4	34										G	13340984	C	G	13340984	3	3	59	1	0	0	0	0	1	0	0	0	2538	835	29	1	2229	1	CACNA1A	19	13340984	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	429150	13340984	45787999	413	17216										
CYP4F8	11283	broad.mit.edu	37	chr19	15734173	15734173	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttggactttattgatgtgctCctgctgagcgaggtgggcct	14	8	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:15734173C>T	uc002nbi.2	+	9	970	c.906C>T	c.(904-906)CTC>CTT	p.L302L	CYP4F8_uc010xoj.1_Silent_p.L114L	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	302					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TTGATGTGCTCCTGCTGAGCG	0.537													0	0	0	0.003163	0	12	34										T	15734173	C	T	15734173	2	4	59	1	0	0	0	0	0	0	0	1	4191	842	30	1		1	CYP4F8	19	15734173	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2393189	15734173	43394810	414	17217										
CYP4F2	8529	broad.mit.edu	37	chr19	16001219	16001219	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atccaaacaggcactaccctCtgaggccaggagctgccact	9	15	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:16001219C>G	uc002nbs.1	-	6	600	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	CYP4F2_uc010xot.1_Missense_Mutation_p.E35Q|CYP4F2_uc010xou.1_Missense_Mutation_p.E35Q	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	184					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GCACTACCCTCTGAGGCCAGG	0.542													0	0	0	0.016522	0	19	75										G	16001219	C	G	16001219	3	3	59	1	0	0	0	0	1	0	0	0	4188	922	32	1	1044	1	CYP4F2	19	16001219	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	267046	16001219	43127764	415	17218										
ABHD8	79575	broad.mit.edu	37	chr19	17411697	17411697	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccaatgagcacatttcgcttCttggcatagcgcttgaagat	9	10	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:17411697C>T	uc002ngb.3	-	2	969	c.729G>A	c.(727-729)AAG>AAA	p.K243K		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	243							hydrolase activity				0						CATTTCGCTTCTTGGCATAGC	0.597													0	0	0	0.007835	0	36	150										T	17411697	C	T	17411697	2	4	59	1	0	0	0	0	0	0	0	1	87	912	32	1		1	ABHD8	19	17411697	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1410478	17411697	41717286	416	17219										
KCNN1	3780	broad.mit.edu	37	chr19	18099287	18099287	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agctggagctcaccaaggctGagaagcacgtgcacaacttc	11	12	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:18099287G>A	uc002nht.2	+	7	1433	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K	KCNN1_uc010xqa.1_Missense_Mutation_p.E375K	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	375					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						CACCAAGGCTGAGAAGCACGT	0.637													0	0	0	0.004482	0	7	16										A	18099287	G	A	18099287	3	1	59	1	0	0	0	0	1	0	0	0	8078	1291	45	1	1141	1	KCNN1	19	18099287	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	687590	18099287	41029696	417	17220										
KIAA1683	80726	broad.mit.edu	37	chr19	18376060	18376060	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gtgggtgttgctgctgagatCagcagcctggtgcgctggga	18	8	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:18376060C>T	uc002nin.2	-	3	2506	c.2290G>A	c.(2290-2292)GAT>AAT	p.D764N	KIAA1683_uc010ebn.2_Missense_Mutation_p.D764N|KIAA1683_uc010xqe.1_Missense_Mutation_p.D718N	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	764						mitochondrion				ovary(2)	2						CTGCTGAGATCAGCAGCCTGG	0.657													0	0	0	0.011902	0	39	77										T	18376060	C	T	18376060	3	4	59	1	0	0	0	0	1	0	0	0	8251	826	29	1	1821	1	KIAA1683	19	18376060	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	276773	18376060	40752923	418	17221										
SSBP4	170463	broad.mit.edu	37	chr19	18543520	18543520	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttgtccccagatcccctactCctcctcatcccccggcagct	5	21	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:18543520C>G	uc002niy.2	+	12	999	c.761C>G	c.(760-762)TCC>TGC	p.S254C	SSBP4_uc002niz.2_Missense_Mutation_p.S232C	NM_032627	NP_116016	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4 isoform a	254	Pro-rich.					nucleus	single-stranded DNA binding				0						ATCCCCTACTCCTCCTCATCC	0.642													0	0	0	0.006214	0	7	16										G	18543520	C	G	18543520	3	3	59	1	0	0	0	0	1	0	0	0	15181	855	30	1	807	1	SSBP4	19	18543520	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	167460	18543520	40585463	419	17222										
GPATCH1	55094	broad.mit.edu	37	chr19	33608848	33608848	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agtcctcatcctccgaggatGagcaaggtgacagtgaagat	12	9	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:33608848G>A	uc002nug.1	+	16	2628	c.2314G>A	c.(2314-2316)GAG>AAG	p.E772K	GPATCH1_uc002nuh.1_Missense_Mutation_p.E149K	NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	772						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					CTCCGAGGATGAGCAAGGTGA	0.552													0	0	0	0.00308	0	7	57										A	33608848	G	A	33608848	3	1	59	1	0	0	0	0	1	0	0	0	6590	1291	45	1	2376	1	GPATCH1	19	33608848	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	15065328	33608848	25520135	420	17223										
ZNF599	148103	broad.mit.edu	37	chr19	35250830	35250830	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ataaaagaagagcggtgggtGaatgctttgccacattcttt	11	6	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:35250830G>A	uc010edn.1	-	4	1264	c.876C>T	c.(874-876)TTC>TTT	p.F292F	ZNF599_uc010edm.1_Silent_p.F255F	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	292	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			AGCGGTGGGTGAATGCTTTGC	0.453													0	0	0	0.013114	0	42	96										A	35250830	G	A	35250830	2	1	59	1	0	0	0	0	0	0	0	1	18026	1281	45	1		1	ZNF599	19	35250830	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1641982	35250830	23878153	421	17224										
ZNF585B	92285	broad.mit.edu	37	chr19	37677474	37677474	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tacatatatagggcttcactCttgtgtgaacacgttgatgt	9	7	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:37677474C>G	uc002ofq.2	-	5	1219	c.965G>C	c.(964-966)AGA>ACA	p.R322T	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.R136T	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGGCTTCACTCTTGTGTGAAC	0.378													0	0	0	0.003755	0	30	130										G	37677474	C	G	37677474	3	3	59	1	0	0	0	0	1	0	0	0	18015	913	32	1	1348	1	ZNF585B	19	37677474	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2426644	37677474	21451509	422	17225										
NFKBIB	4793	broad.mit.edu	37	chr19	39399404	39399404	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	acattgtggttcacagcagcCgcagccaaacccggctgcct	10	15	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:39399404C>T	uc002ojw.2	+	6	1061	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	335					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TCACAGCAGCCGCAGCCAAAC	0.567													0	0	0	0.01441	0	38	85										T	39399404	C	T	39399404	3	4	59	1	0	0	0	0	1	0	0	0	10378	652	23	2	1073	2	NFKBIB	19	39399404	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1721930	39399404	19729579	423	17226										
NFKBIB	4793	broad.mit.edu	37	chr19	39399438	39399438	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctgcctcccaccccagcctCaaaacctcttcctgacgacc	5	21	2	1	rs11551804		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:39399438C>G	uc002ojw.2	+	6	1095	c.1037C>G	c.(1036-1038)TCA>TGA	p.S346*	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	346					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACCCCAGCCTCAAAACCTCTT	0.527													0	0	0	0.00874	0	35	79										G	39399438	C	G	39399438	4	3	59	1	0	0	0	0	0	1	0	0	10378	838	29	1	1107	1	NFKBIB	19	39399438	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	34	39399438	19729545	424	17227										
CYP2F1	1572	broad.mit.edu	37	chr19	41622139	41622139	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tactcctgctcctggctctcGtctgtctgctcctgacccta	7	17	3	1	rs142026539		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:41622139G>A	uc002opu.1	+	2	102	c.46G>A	c.(46-48)GTC>ATC	p.V16I	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Missense_Mutation_p.V16I|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	16					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CCTGGCTCTCGTCTGTCTGCT	0.577													0	0	0	0.006122	0	15	121										A	41622139	G	A	41622139	3	1	59	1	0	0	0	0	1	0	0	0	4171	1145	40	2	48	2	CYP2F1	19	41622139	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2222701	41622139	17506844	425	17228										
EXOC3L2	90332	broad.mit.edu	37	chr19	45720793	45720793	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcccgacactgaccagccgcCggaacagcctctgcagttgc	10	17	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:45720793C>T	uc002pay.1	-	8	853	c.812G>A	c.(811-813)CGG>CAG	p.R271Q		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	271	Potential.									ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GACCAGCCGCCGGAACAGCCT	0.701													0	0	0	0.004672	0	3	12										T	45720793	C	T	45720793	3	4	59	1	0	0	0	0	1	0	0	0	5305	652	23	2	429	2	EXOC3L2	19	45720793	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4098654	45720793	13408190	426	17229										
MARK4	57787	broad.mit.edu	37	chr19	45767943	45767943	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctgttcccaaccattatagtGaagctctttgaggtgattga	9	8	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:45767943G>A	uc002pbb.1	+	5	362	c.357G>A	c.(355-357)GTG>GTA	p.V119V	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.V119V|MARK4_uc002pbc.1_5'UTR			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	119	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCATTATAGTGAAGCTCTTTG	0.552													0	0	0	0.011902	0	38	91										A	45767943	G	A	45767943	2	1	59	1	0	0	0	0	0	0	0	1	9315	1304	45	1		1	MARK4	19	45767943	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	47150	45767943	13361040	427	17230										
FOSB	2354	broad.mit.edu	37	chr19	45975962	45975962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccgggccgggcccgctggcgGaggtgagagatttgccgggc	20	12	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:45975962G>A	uc002pbx.3	+	4	1301	c.709G>A	c.(709-711)GAG>AAG	p.E237K	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Missense_Mutation_p.E162K|FOSB_uc002pby.3_Missense_Mutation_p.E201K|FOSB_uc010eka.1_Missense_Mutation_p.E198K|FOSB_uc010ekb.1_Missense_Mutation_p.E237K|FOSB_uc010ekc.1_Missense_Mutation_p.E94K|FOSB_uc010ekf.2_Missense_Mutation_p.E198K|FOSB_uc010ekd.1_Missense_Mutation_p.E201K|FOSB_uc010ekg.2_Missense_Mutation_p.E94K|FOSB_uc002pca.3_Missense_Mutation_p.E188K	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	237					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		CCCGCTGGCGGAGGTGAGAGA	0.667													0	0	0	0.008291	0	9	22										A	45975962	G	A	45975962	3	1	59	1	0	0	0	0	1	0	0	0	5986	1175	41	1	723	1	FOSB	19	45975962	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	208019	45975962	13153021	428	17231										
ZC3H4	23211	broad.mit.edu	37	chr19	47572355	47572355	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gggcggacacgtgccttcctCattctcccggtcctgcttgc	11	16	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:47572355C>T	uc002pga.3	-	14	2430	c.2392G>A	c.(2392-2394)GAG>AAG	p.E798K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	798	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GTGCCTTCCTCATTCTCCCGG	0.677													0	0	0	0.007835	0	39	107										T	47572355	C	T	47572355	3	4	59	1	0	0	0	0	1	0	0	0	17567	835	29	1	1527	1	ZC3H4	19	47572355	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1596393	47572355	11556628	429	17232										
EHD2	30846	broad.mit.edu	37	chr19	48244215	48244215	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaggcactggacgagatgctGacgcacgacatcgccaagct	13	12	0	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:48244215G>A	uc002phj.3	+	6	1408	c.1158G>A	c.(1156-1158)CTG>CTA	p.L386L	EHD2_uc010xyu.1_Silent_p.L250L|EHD2_uc010xyv.1_Silent_p.L69L	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	386					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		ACGAGATGCTGACGCACGACA	0.647													0	0	0	0.003954	0	22	31										A	48244215	G	A	48244215	2	1	59	1	0	0	0	0	0	0	0	1	4978	1277	45	1		1	EHD2	19	48244215	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	671860	48244215	10884768	430	17233										
ALDH16A1	126133	broad.mit.edu	37	chr19	49967512	49967512	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctggggcaggcgctggagctGggctatgggtcagtctgcgt	19	9	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:49967512G>A	uc002pnt.2	+	10	1439	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	ALDH16A1_uc010yar.1_Silent_p.L390L|ALDH16A1_uc010yas.1_Silent_p.L276L|ALDH16A1_uc010yat.1_Silent_p.L278L	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	441							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CGCTGGAGCTGGGCTATGGGT	0.667													0	0	0	0.001168	0	5	14										A	49967512	G	A	49967512	2	1	59	1	0	0	0	0	0	0	0	1	488	1335	47	2		2	ALDH16A1	19	49967512	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1723297	49967512	9161471	431	17234										
ZNF880	400713	broad.mit.edu	37	chr19	52887440	52887440	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cttcaagacttgctaacaatCaagtaatccacactgcagat	5	11	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:52887440C>G	uc002pzc.2	+	4	656	c.607C>G	c.(607-609)CAA>GAA	p.Q203E		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	203	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TGCTAACAATCAAGTAATCCA	0.373													0	0	0	0.001168	0	6	16										G	52887440	C	G	52887440	3	3	59	1	0	0	0	0	1	0	0	0	18194	827	29	1	621	1	ZNF880	19	52887440	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2919928	52887440	6241543	432	17235										
LENG9	94059	broad.mit.edu	37	chr19	54973627	54973627	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggggccaagagggcccgtctCagagctccaatggcagcggc	16	13	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:54973627C>T	uc010yez.1	-	1	1268	c.1149G>A	c.(1147-1149)CTG>CTA	p.L383L		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	383					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		GGGCCCGTCTCAGAGCTCCAA	0.657													0	0	0	0.006214	0	7	39										T	54973627	C	T	54973627	2	4	59	1	0	0	0	0	0	0	0	1	8725	813	29	1		1	LENG9	19	54973627	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2086187	54973627	4155356	433	17236										
LILRA1	11024	broad.mit.edu	37	chr19	55107923	55107923	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccaacccctacctgctgtctCaccccagtgactccctggag	7	19	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:55107923C>T	uc002qgh.1	+	7	1410	c.1228C>T	c.(1228-1230)CAC>TAC	p.H410Y	LILRA2_uc010yfg.1_Missense_Mutation_p.H408Y|LILRA1_uc010yfh.1_Missense_Mutation_p.H410Y	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	410	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CCTGCTGTCTCACCCCAGTGA	0.612													0	0	0	0.01441	0	38	108										T	55107923	C	T	55107923	3	4	59	1	0	0	0	0	1	0	0	0	8784	826	29	1	1250	1	LILRA1	19	55107923	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	134296	55107923	4021060	434	17237										
KIR2DL1	3802	broad.mit.edu	37	chr19	55294990	55294990	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aacagaacagcgaatagcgaGgtaggtactcctcggcccgg	13	11	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:55294990G>A	uc002qhb.1	+	7	908	c.870G>A	c.(868-870)GAG>GAA	p.E290E	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_5'Flank|KIR2DL3_uc010erw.1_Silent_p.E291E|KIR2DL1_uc002qgz.1_Silent_p.E200E|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Silent_p.E316E	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	290	Cytoplasmic (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		CGAATAGCGAGGTAGGTACTC	0.532													0	0	0	0.010771	0	35	81										A	55294990	G	A	55294990	2	1	59	1	0	0	0	0	0	0	0	1	8316	1014	35	2		2	KIR2DL1	19	55294990	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	187067	55294990	3833993	435	17238										
NLRP2	55655	broad.mit.edu	37	chr19	55508805	55508805	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttggggtctagtggagtgaaGatgctgtttgaaaccttgac	14	5	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:55508805G>C	uc002qij.2	+	12	3086	c.3000G>C	c.(2998-3000)AAG>AAC	p.K1000N	NLRP2_uc010yfp.1_Missense_Mutation_p.K977N|NLRP2_uc010esn.2_Missense_Mutation_p.K976N|NLRP2_uc010eso.2_Missense_Mutation_p.K997N|NLRP2_uc010esp.2_Missense_Mutation_p.K978N	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1000	LRR 7.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTGGAGTGAAGATGCTGTTTG	0.527													0	0	0	0.008361	0	24	133										C	55508805	G	C	55508805	3	2	59	1	0	0	0	0	1	0	0	0	10477	933	33	1	3042	1	NLRP2	19	55508805	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	213815	55508805	3620178	436	17239										
ZNF749	388567	broad.mit.edu	37	chr19	57956341	57956341	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atcagagaattcacactggaGaaaagccttataaatgcagc	8	8	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:57956341G>A	uc002qoq.2	+	3	2079	c.1825G>A	c.(1825-1827)GAA>AAA	p.E609K	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TCACACTGGAGAAAAGCCTTA	0.388													0	0	0	0.006214	0	7	57										A	57956341	G	A	57956341	3	1	59	1	0	0	0	0	1	0	0	0	18128	943	33	1	1835	1	ZNF749	19	57956341	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	2447536	57956341	1172642	437	17240										
CHMP2A	27243	broad.mit.edu	37	chr19	59063468	59063468	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	catggcatcatcaatggcatCattcatcatctcctccttca	4	14	7	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:59063468C>T	uc002qti.2	-	3	859	c.433G>A	c.(433-435)GAT>AAT	p.D145N	CHMP2A_uc002qtj.2_Missense_Mutation_p.D145N|CHMP2A_uc002qtk.2_Missense_Mutation_p.D145N	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	145	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TCAATGGCATCATTCATCATC	0.517													0	0	0	0.010771	0	39	181										T	59063468	C	T	59063468	3	4	59	1	0	0	0	0	1	0	0	0	3354	826	29	1	247	1	CHMP2A	19	59063468	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1107127	59063468	65515	438	17241										
ZCCHC3	85364	broad.mit.edu	37	chr20	279262	279262	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgtggttcccggacccacatGagcggcagctgcacgcagga	14	13	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:279262G>C	uc002wdf.2	+	2	1056	c.1032G>C	c.(1030-1032)ATG>ATC	p.M344I	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	345	CCHC-type 1.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GGACCCACATGAGCGGCAGCT	0.637													0	0	0	0.003954	0	23	80										C	279262	G	C	279262	3	2	59	1	0	0	0	0	1	0	0	0	17586	1290	45	1	1037	1	ZCCHC3	20	279262	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		279262	62746258	439	17242										
C20orf7	79133	broad.mit.edu	37	chr20	13765904	13765904	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actgggcagcccggcagcccGagccgaccaaatttgactac	11	15	0	1	rs147117631		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:13765904G>T	uc002wom.2	+	1	223	c.190G>T	c.(190-192)GAG>TAG	p.E64*	ESF1_uc002woj.2_5'Flank|ESF1_uc002wok.1_5'Flank|C20orf7_uc002wol.1_Nonsense_Mutation_p.E64*|C20orf7_uc002won.2_Nonsense_Mutation_p.E64*|C20orf7_uc002woo.2_RNA	NM_024120	NP_077025	Q5TEU4	CT007_HUMAN	hypothetical protein LOC79133 isoform 1	64					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity				0		Myeloproliferative disorder(85;0.00878)				CCGGCAGCCCGAGCCGACCAA	0.473													1	0	0.004672	0.004672	0.00479611	3	18										T	13765904	G	T	13765904	4	4	59	1	0	0	0	0	0	1	0	0	2115	1059	37	3	192	3	C20orf7	20	13765904	Nonsense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	13486642	13765904	49259616	440	17243										
SEC23B	10483	broad.mit.edu	37	chr20	18508212	18508212	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tttatgcttgtgcccttgatCaaactggacttttggagatg	10	7	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:18508212C>G	uc002wqz.1	+	9	1509	c.1066C>G	c.(1066-1068)CAA>GAA	p.Q356E	SEC23B_uc002wra.1_Missense_Mutation_p.Q356E|SEC23B_uc002wrb.1_Missense_Mutation_p.Q356E|SEC23B_uc010zsb.1_Missense_Mutation_p.Q338E|SEC23B_uc002wrc.1_Missense_Mutation_p.Q356E	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	356					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						TGCCCTTGATCAAACTGGACT	0.408													0	0	0	0.01441	0	74	297										G	18508212	C	G	18508212	3	3	59	1	0	0	0	0	1	0	0	0	13992	827	29	1	1096	1	SEC23B	20	18508212	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	4742308	18508212	44517308	441	17244										
SEC23B	10483	broad.mit.edu	37	chr20	18513307	18513307	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	actgtcacatatttgttataGacctctcgggaactgaagat	8	8	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:18513307G>C	uc002wqz.1	+	11	1677	c.1234_splice	c.e11-1	p.T412_splice	SEC23B_uc002wra.1_Splice_Site_p.T412_splice|SEC23B_uc002wrb.1_Splice_Site_p.T412_splice|SEC23B_uc010zsb.1_Splice_Site_p.T394_splice|SEC23B_uc002wrc.1_Splice_Site_p.T412_splice	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						ATTTGTTATAGACCTCTCGGG	0.413													0	0	0	0.012319	0	18	57										C	18513307	G	C	18513307	5	2	59	1	0	0	0	0	0	0	1	0	13992	956	33	1	1271	1	SEC23B	20	18513307	Splice_Site	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	5095	18513307	44512213	442	17245										
C20orf185	359710	broad.mit.edu	37	chr20	31647285	31647285	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	caaagtgggcatgcattgctCtgggtgagtgtgtcctgggg	17	7	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:31647285C>G	uc002wym.1	+	3	383	c.383C>G	c.(382-384)TCC>TGC	p.S128C		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	128	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						ATGCATTGCTCTGGGTGAGTG	0.602													0	0	0	0.004672	0	3	7										G	31647285	C	G	31647285	3	3	59	1	0	0	0	0	1	0	0	0	2097	913	32	1	393	1	C20orf185	20	31647285	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	13133978	31647285	31378235	443	17246										
EPB41L1	2036	broad.mit.edu	37	chr20	34797558	34797558	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggccattgagcgcaagtgctCcagcatcacggtcagctcta	11	13	3	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:34797558C>G	uc002xfb.2	+	15	1988	c.1817C>G	c.(1816-1818)TCC>TGC	p.S606C	EPB41L1_uc002xeu.2_Missense_Mutation_p.S532C|EPB41L1_uc010zvo.1_Missense_Mutation_p.S606C|EPB41L1_uc002xev.2_Missense_Mutation_p.S606C|EPB41L1_uc002xew.2_Missense_Mutation_p.S497C|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Missense_Mutation_p.S532C|EPB41L1_uc010gfq.2_Missense_Mutation_p.S705C	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	606					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CGCAAGTGCTCCAGCATCACG	0.612													0	0	0	0.006122	0	17	42										G	34797558	C	G	34797558	3	3	59	1	0	0	0	0	1	0	0	0	5152	855	30	1	1871	1	EPB41L1	20	34797558	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3150273	34797558	28227962	444	17247										
R3HDML	140902	broad.mit.edu	37	chr20	42969880	42969880	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctgccgaagcctgggccacCcagtgcatctgggcacatgg	14	14	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:42969880C>T	uc002xls.1	+	2	478	c.306C>T	c.(304-306)ACC>ACT	p.T102T		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	102						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CCTGGGCCACCCAGTGCATCT	0.587													0	0	0	0.008361	0	25	54										T	42969880	C	T	42969880	2	4	59	1	0	0	0	0	0	0	0	1	12889	610	22	2		2	R3HDML	20	42969880	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	8172322	42969880	20055640	445	17248										
SLC9A8	23315	broad.mit.edu	37	chr20	48500483	48500483	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accaccatcgtcatcgtgctCttcaccatcctgctgctggg	8	16	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:48500483C>T	uc002xuv.1	+	14	1581	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L	SLC9A8_uc010zym.1_Silent_p.L157L|SLC9A8_uc010gic.2_Silent_p.L157L|SLC9A8_uc010gid.2_Silent_p.L81L	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	457	Helical; (Potential).					Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TCATCGTGCTCTTCACCATCC	0.632													0	0	0	0.00632	0	26	120										T	48500483	C	T	48500483	2	4	59	1	0	0	0	0	0	0	0	1	14720	900	32	1		1	SLC9A8	20	48500483	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	5530603	48500483	14525037	446	17249										
LAMA5	3911	broad.mit.edu	37	chr20	60897153	60897153	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctgcaggtgtcgcagcgctCcccgctgagccccggggggc	17	16	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:60897153C>G	uc002ycq.2	-	48	6485	c.6418G>C	c.(6418-6420)GAG>CAG	p.E2140Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2140	Laminin EGF-like 22.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGCAGCGCTCCCCGCTGAGC	0.692													0	0	0	0.004482	0	9	19										G	60897153	C	G	60897153	3	3	59	1	0	0	0	0	1	0	0	0	8609	864	30	1	4801	1	LAMA5	20	60897153	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	12396670	60897153	2128367	447	17250										
C20orf11	54994	broad.mit.edu	37	chr20	61574870	61574870	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	cagcatttgatcgagctgatCcgccagcgggagacagaggc	14	11	0	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:61574870C>T	uc002ydy.2	+	4	516	c.339C>T	c.(337-339)ATC>ATT	p.I113I		NM_017896	NP_060366	Q9NWU2	CT011_HUMAN	chromosome 20 open reading frame 11	113	CTLH.					nucleus	protein binding				0	Breast(26;5.68e-08)					TCGAGCTGATCCGCCAGCGGG	0.622													0	0	0	0.004007	0	15	44										T	61574870	C	T	61574870	2	4	59	1	0	0	0	0	0	0	0	1	2079	845	30	1		1	C20orf11	20	61574870	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	677717	61574870	1450650	448	17251										
TIAM1	7074	broad.mit.edu	37	chr21	32519223	32519223	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gaggccttacctttcaccagGaccttgggaacttttgtgtg	11	10	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:32519223G>T	uc002yow.1	-	21	3937	c.3465C>A	c.(3463-3465)GTC>GTA	p.V1155V	TIAM1_uc011adk.1_Silent_p.V1155V|TIAM1_uc011adl.1_Silent_p.V1095V	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1155	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CTTTCACCAGGACCTTGGGAA	0.527													1	0	1.11149e-13	0.008291	1.18369e-13	9	28										T	32519223	G	T	32519223	2	4	59	1	0	0	0	0	0	0	0	1	15887	1161	41	3		3	TIAM1	21	32519223	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		32519223	15610672	449	17252										
TIAM1	7074	broad.mit.edu	37	chr21	32519296	32519296	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggtcagcataatacaggaatGatccccccagagagaacagc	10	11	1	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:32519296G>A	uc002yow.1	-	21	3864	c.3392C>T	c.(3391-3393)TCA>TTA	p.S1131L	TIAM1_uc011adk.1_Missense_Mutation_p.S1131L|TIAM1_uc011adl.1_Missense_Mutation_p.S1071L	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1131	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ATACAGGAATGATCCCCCCAG	0.502													0	0	0	0.00499	0	15	34										A	32519296	G	A	32519296	3	1	59	1	0	0	0	0	1	0	0	0	15887	1294	45	1	1419	1	TIAM1	21	32519296	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	73	32519296	15610599	450	17253										
CRYZL1	9946	broad.mit.edu	37	chr21	34975814	34975814	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccgaatgcttcctgctgcttCcgtccatgtgaccttttctg	8	14	1	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:34975814C>T	uc011adw.1	-	7	541	c.361G>A	c.(361-363)GAA>AAA	p.E121K	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Missense_Mutation_p.E145K|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	121					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						CCTGCTGCTTCCGTCCATGTG	0.333													0	0	0	0.008871	0	15	63										T	34975814	C	T	34975814	3	4	59	1	0	0	0	0	1	0	0	0	3923	864	30	1	716	1	CRYZL1	21	34975814	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2456518	34975814	13154081	451	17254										
TTC3	7267	broad.mit.edu	37	chr21	38568048	38568048	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgacttctgcaagcgacgtgActggaaaccacgcagcactt	10	12	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:38568048A>T	uc002yvz.2	+	42	5395	c.5290A>T	c.(5290-5292)ACT>TCT	p.T1764S	TTC3_uc002ywa.2_Missense_Mutation_p.T1764S|TTC3_uc002ywb.2_Missense_Mutation_p.T1764S|TTC3_uc010gnf.2_Missense_Mutation_p.T1529S|TTC3_uc002ywc.2_Missense_Mutation_p.T1454S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1764					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AAGCGACGTGACTGGAAACCA	0.587													0	0	0	0.007413	0	18	105										T	38568048	A	T	38568048	3	4	59	1	0	0	0	0	1	0	0	0	16694	275	10	5	5452	5	TTC3	21	38568048	Missense_Mutation	SNP	A	TCGA-DK-A3IN-01A-11D-A20D-08	3592234	38568048	9561847	452	17255										
PRDM15	63977	broad.mit.edu	37	chr21	43291624	43291624	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aggaggtagggcaggattgcGtcgcaggcctgcactcgcag	17	10	0	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:43291624G>A	uc002yzq.1	-	4	631	c.520C>T	c.(520-522)CGC>TGC	p.R174C	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCAGGATTGCGTCGCAGGCCT	0.592													0	0	0	0.007291	0	24	61										A	43291624	G	A	43291624	3	1	59	1	0	0	0	0	1	0	0	0	12456	1145	40	2	4115	2	PRDM15	21	43291624	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	4723576	43291624	4838271	453	17256										
C21orf2	755	broad.mit.edu	37	chr21	45751736	45751736	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ccagcctcacgttgcctcctCctcgctgtccagcgggtccc	9	20	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:45751736C>G	uc002zep.2	-	5	743	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	C21orf2_uc002zeo.1_Missense_Mutation_p.E138Q|C21orf2_uc002zeq.2_Missense_Mutation_p.E179Q|C21orf2_uc002zer.2_Missense_Mutation_p.E179Q	NM_004928	NP_004919	O43822	CU002_HUMAN	hypothetical protein LOC755	179											0				Colorectal(79;0.0806)		GTTGCCTCCTCCTCGCTGTCC	0.692													0	0	0	0.009096	0	3	12										G	45751736	C	G	45751736	3	3	59	1	0	0	0	0	1	0	0	0	2123	864	30	1	247	1	C21orf2	21	45751736	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	2460112	45751736	2378159	454	17257										
GAB4	128954	broad.mit.edu	37	chr22	17447110	17447110	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aagcaggtcaaagcgaacaaGacatgagcccacagggatgc	12	10	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:17447110G>A	uc002zlw.2	-	6	1276	c.1168C>T	c.(1168-1170)CTT>TTT	p.L390F	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	390										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AAGCGAACAAGACATGAGCCC	0.607													0	0	0	0.004007	0	15	76										A	17447110	G	A	17447110	3	1	59	1	0	0	0	0	1	0	0	0	6151	942	33	1	576	1	GAB4	22	17447110	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08		17447110	33857456	455	17258										
THAP7	80764	broad.mit.edu	37	chr22	21354959	21354959	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ttcctgcatcgtctgagccgGctgacttcagcggggccagg	14	13	2	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:21354959G>T	uc002ztr.1	-	4	384	c.354C>A	c.(352-354)AGC>AGA	p.S118R	THAP7_uc002zts.1_Missense_Mutation_p.S118R|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	118					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GTCTGAGCCGGCTGACTTCAG	0.612													1	0	9.16793e-09	0.00499	9.64951e-09	17	251										T	21354959	G	T	21354959	3	4	59	1	0	0	0	0	1	0	0	0	15846	1194	42	4	583	4	THAP7	22	21354959	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	3907849	21354959	29949607	456	17259										
ZNF280B	140883	broad.mit.edu	37	chr22	22842526	22842526	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ctggcacacatagggcatttCgccaggcttatgatggtcct	11	11	0	1			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:22842526C>T	uc002zwc.1	-	4	1974	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TAGGGCATTTCGCCAGGCTTA	0.433													0	0	0	0.013114	0	42	236										T	22842526	C	T	22842526	3	4	59	1	0	0	0	0	1	0	0	0	17812	893	31	1	437	1	ZNF280B	22	22842526	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	1487567	22842526	28462040	457	17260										
CYTSA	23384	broad.mit.edu	37	chr22	24761541	24761541	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	atgggaaccacgtctccacaGctttccctgtcctcttctcc	6	17	3	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:24761541G>A	uc002zzw.2	+	13	3232	c.2925G>A	c.(2923-2925)CAG>CAA	p.Q975Q	CYTSA_uc002zzv.3_Silent_p.Q975Q|CYTSA_uc011ajq.1_Silent_p.Q975Q	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	975					cell cycle|cell division						0						CGTCTCCACAGCTTTCCCTGT	0.512													0	0	0	0.00874	0	35	162										A	24761541	G	A	24761541	2	1	59	1	0	0	0	0	0	0	0	1	4209	962	34	2		2	CYTSA	22	24761541	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1919015	24761541	26543025	458	17261										
PISD	23761	broad.mit.edu	37	chr22	32017073	32017073	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	aggtagatgacacagtgataGagctcattcccttcccgggt	11	10	1	4			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:32017073G>C	uc003alm.3	-	6	760	c.753C>G	c.(751-753)CTC>CTG	p.L251L	PISD_uc003alk.2_Silent_p.L217L|PISD_uc003all.2_Silent_p.L216L|PISD_uc011alr.1_Silent_p.L216L|PISD_uc003aln.3_Silent_p.L251L	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	251					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	CACAGTGATAGAGCTCATTCC	0.627											OREG0003530	type=REGULATORY REGION|Gene=PISD|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.00632	0	24	77										C	32017073	G	C	32017073	2	2	59	1	0	0	0	0	0	0	0	1	11946	929	33	1		1	PISD	22	32017073	Silent	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7255532	32017073	19287493	459	17262										
SLC5A4	6527	broad.mit.edu	37	chr22	32626965	32626965	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	attttcctaccttggggcatCagttccagcaccatcgtggg	10	12	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:32626965C>G	uc003ami.2	-	10	1121	c.1119G>C	c.(1117-1119)CTG>CTC	p.L373L		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	373	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CTTGGGGCATCAGTTCCAGCA	0.537													0	0	0	0.006122	0	14	44										G	32626965	C	G	32626965	2	3	59	1	0	0	0	0	0	0	0	1	14667	813	29	1		1	SLC5A4	22	32626965	Silent	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	609892	32626965	18677601	460	17263										
RASD2	23551	broad.mit.edu	37	chr22	35947615	35947615	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tcgatgaggtcaagcgccttCagaagcagatcctggaggtc	13	10	2	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:35947615C>T	uc003anx.2	+	3	542	c.337C>T	c.(337-339)CAG>TAG	p.Q113*	RASD2_uc003any.2_Nonsense_Mutation_p.Q113*	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	113					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CAAGCGCCTTCAGAAGCAGAT	0.582													0	0	0	0.004656	0	26	42										T	35947615	C	T	35947615	4	4	59	1	0	0	0	0	0	1	0	0	13067	827	29	1	343	1	RASD2	22	35947615	Nonsense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08	3320650	35947615	15356951	461	17264										
POLDIP3	84271	broad.mit.edu	37	chr22	42998059	42998059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	tgccatggctttctgctgtgGaacctggaaacactcagtgg	12	10	2	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:42998059G>A	uc003bcu.2	-	3	553	c.454C>T	c.(454-456)CCA>TCA	p.P152S	POLDIP3_uc011app.1_Missense_Mutation_p.P73S|POLDIP3_uc003bcv.2_Intron|POLDIP3_uc011apq.1_Missense_Mutation_p.P169S|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_Intron|POLDIP3_uc010gzb.1_Intron	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	152					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						TTCTGCTGTGGAACCTGGAAA	0.507													0	0	0	0.01441	0	44	71										A	42998059	G	A	42998059	3	1	59	1	0	0	0	0	1	0	0	0	12195	1174	41	1	839	1	POLDIP3	22	42998059	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7050444	42998059	8306507	462	17265										
RBM10	8241	broad.mit.edu	37	chrX	47045024	47045024	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	accagcagctctcagggctcCacaaggtaacagcggatggt	12	12	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:47045024C>G	uc004dhf.2	+	20	2729	c.2350C>G	c.(2350-2352)CAC>GAC	p.H784D	RBM10_uc004dhg.2_Missense_Mutation_p.H706D|RBM10_uc004dhh.2_Missense_Mutation_p.H783D|RBM10_uc010nhq.2_Missense_Mutation_p.H707D|RBM10_uc004dhi.2_Missense_Mutation_p.H849D	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	784	C2H2-type; atypical.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CTCAGGGCTCCACAAGGTAAC	0.612													0	0	0	0.014758	0	4	3										G	47045024	C	G	47045024	3	3	59	1	0	0	0	0	1	0	0	0	13111	594	21	4	2424	4	RBM10	23	47045024	Missense_Mutation	SNP	C	TCGA-DK-A3IN-01A-11D-A20D-08		47045024	108225536	463	17266										
FAM120C	54954	broad.mit.edu	37	chrX	54162953	54162953	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	agggacccactggcagcgaaGagagtttggttgtgactgaa	15	7	0	3			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:54162953G>C	uc004dsz.3	-	5	1312	c.1229C>G	c.(1228-1230)TCT>TGT	p.S410C	FAM120C_uc011moh.1_Missense_Mutation_p.S410C	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	410										ovary(1)|central_nervous_system(1)	2						TGGCAGCGAAGAGAGTTTGGT	0.463													0	0	0	0.00499	0	15	45										C	54162953	G	C	54162953	3	2	59	1	0	0	0	0	1	0	0	0	5418	942	33	1	2109	1	FAM120C	23	54162953	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	7117929	54162953	101107607	464	17267										
ARMCX5	64860	broad.mit.edu	37	chrX	101857613	101857613	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	ggactggagaagagcctagtGtagggtcctggttctggcct	16	8	1	2			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:101857613G>A	uc004ejg.2	+	6	1425	c.544G>A	c.(544-546)GTA>ATA	p.V182I	ARMCX5_uc004ejh.2_Missense_Mutation_p.V182I	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	182							binding			ovary(1)	1						AGAGCCTAGTGTAGGGTCCTG	0.488													0	0	0	0.001855	0	12	45										A	101857613	G	A	101857613	3	1	59	1	0	0	0	0	1	0	0	0	962	1377	48	2	546	2	ARMCX5	23	101857613	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	47694660	101857613	53412947	465	17268										
ESX1	80712	broad.mit.edu	37	chrX	103499060	103499060	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.554838709677419	258	1.3085243498351e-102	4.27892131475303	5.10786990325835	3.71264367816092	0.546509353345411	0.703427880543598	198	gctcctcctgctgttgctccGgcttggtcaggggcggctcc	14	15	1	0			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:103499060G>A	uc004ely.2	-	2	339	c.281C>T	c.(280-282)CCG>CTG	p.P94L		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	94					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTGTTGCTCCGGCTTGGTCAG	0.716													0	0	0	0.010818	0	27	33										A	103499060	G	A	103499060	3	1	59	1	0	0	0	0	1	0	0	0	5263	1116	39	2	951	2	ESX1	23	103499060	Missense_Mutation	SNP	G	TCGA-DK-A3IN-01A-11D-A20D-08	1641447	103499060	51771500	466	17269										
TP73	7161	broad.mit.edu	37	chr1	3640003	3640003	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gaccctgtcaccggcaggcaGagcgtcgtggtgccctatga	14	13	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:3640003G>A	uc001akp.2	+	6	812	c.702G>A	c.(700-702)CAG>CAA	p.Q234Q	TP73_uc001akq.2_Silent_p.Q234Q|TP73_uc010nzj.1_Silent_p.Q185Q|TP73_uc001akr.2_Silent_p.Q185Q|TP73_uc009vlk.1_Silent_p.Q185Q|TP73_uc001aks.2_Silent_p.Q185Q|TP73_uc010nzk.1_Silent_p.Q163Q	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	234	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CCGGCAGGCAGAGCGTCGTGG	0.657													0	0	0	0.014758	0	5	39										A	3640003	G	A	3640003	2	1	60	1	0	0	0	0	0	0	0	1	16390	933	33	1		1	TP73	1	3640003	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		3640003	245610618	1	17270										
VPS13D	55187	broad.mit.edu	37	chr1	12389897	12389897	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcattgcaggtctgaattttCttcagcgtgtaagaactagc	9	8	4	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:12389897C>G	uc001atv.2	+	37	8350	c.8209C>G	c.(8209-8211)CTT>GTT	p.L2737V	VPS13D_uc001atw.2_Missense_Mutation_p.L2737V|VPS13D_uc001atx.2_Missense_Mutation_p.L1925V|VPS13D_uc001aty.1_Missense_Mutation_p.L475V	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2737					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCTGAATTTTCTTCAGCGTGT	0.428													0	0	0	0.105934	0	11	39										G	12389897	C	G	12389897	3	3	60	1	0	0	0	0	1	0	0	0	17189	913	32	1	8351	1	VPS13D	1	12389897	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	8749894	12389897	236860724	2	17271										
UQCRHL	440567	broad.mit.edu	37	chr1	16133952	16133952	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gagctcctccgtgcaatcctCttctgtatgtgatcgagagg	11	11	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:16133952C>A	uc009vol.1	-	1	243	c.193G>T	c.(193-195)GAG>TAG	p.E65*		NM_001089591	NP_001083060			ubiquinol-cytochrome c reductase hinge												0						GTGCAATCCTCTTCTGTATGT	0.463													1	0	2.32078e-09	0.024245	2.57143e-09	13	154										A	16133952	C	A	16133952	4	1	60	1	0	0	0	0	0	1	0	0	17020	922	32	3	86	3	UQCRHL	1	16133952	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	3744055	16133952	233116669	3	17272										
ARHGEF10L	55160	broad.mit.edu	37	chr1	17958953	17958953	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atgcttgtctgtgccaacatCaacttcaagtaagtgggcct	9	10	3	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:17958953C>G	uc001ban.2	+	16	1881	c.1722C>G	c.(1720-1722)ATC>ATG	p.I574M	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.I535M|ARHGEF10L_uc001bao.2_Missense_Mutation_p.I535M|ARHGEF10L_uc001bap.2_Missense_Mutation_p.I535M|ARHGEF10L_uc010ocr.1_Missense_Mutation_p.I332M|ARHGEF10L_uc001baq.2_Missense_Mutation_p.I340M|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.I352M|ARHGEF10L_uc001bar.2_Missense_Mutation_p.I282M|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	574					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GTGCCAACATCAACTTCAAGT	0.597													0	0	0	0.108266	0	19	132										G	17958953	C	G	17958953	3	3	60	1	0	0	0	0	1	0	0	0	895	816	29	1	1780	1	ARHGEF10L	1	17958953	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1825001	17958953	231291668	4	17273										
MYOM3	127294	broad.mit.edu	37	chr1	24388577	24388577	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggtgcccgtccttatccgatCaccactctccagacgtttgt	8	15	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:24388577C>T	uc001bin.3	-	33	3956	c.3793G>A	c.(3793-3795)GAT>AAT	p.D1265N	MYOM3_uc001bil.3_Missense_Mutation_p.D158N|MYOM3_uc001bim.3_Missense_Mutation_p.D922N	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1265										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CTTATCCGATCACCACTCTCC	0.527													0	0	0	0.055883	0	19	147										T	24388577	C	T	24388577	3	4	60	1	0	0	0	0	1	0	0	0	10093	826	29	1	540	1	MYOM3	1	24388577	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	6429624	24388577	224862044	5	17274										
WDTC1	23038	broad.mit.edu	37	chr1	27623588	27623588	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggtgtgtccaacggtgtgtcCaatggcctgcaccttcatag	12	11	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:27623588C>T	uc009vst.2	+	11	1534	c.999C>T	c.(997-999)TCC>TCT	p.S333S	WDTC1_uc001bno.2_Silent_p.S332S|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Silent_p.S11S	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	333							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		acggtgtgtccaaTGGCCTGC	0.483											OREG0013279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.038147	0	7	21										T	27623588	C	T	27623588	2	4	60	1	0	0	0	0	0	0	0	1	17339	581	21	2		2	WDTC1	1	27623588	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	3235011	27623588	221627033	6	17275										
WDTC1	23038	broad.mit.edu	37	chr1	27631682	27631682	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggctctggaacccccgaccaGaggtgagggtgcagagccaa	15	12	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:27631682G>C	uc009vst.2	+	15	2369	c.1834G>C	c.(1834-1836)GAG>CAG	p.E612Q	WDTC1_uc001bno.2_Missense_Mutation_p.E611Q|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Missense_Mutation_p.E290Q	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	612	WD 7.						protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CCCCCGACCAGAGGTGAGGGT	0.617													0	0	0	0.058154	0	7	24										C	27631682	G	C	27631682	3	2	60	1	0	0	0	0	1	0	0	0	17339	943	33	1	1885	1	WDTC1	1	27631682	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	8094	27631682	221618939	7	17276										
PHACTR4	65979	broad.mit.edu	37	chr1	28818294	28818294	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggaccaaactgacccctgctGacaaggtacctggaaagcac	10	13	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:28818294G>A	uc001bpw.2	+	12	2293	c.2011G>A	c.(2011-2013)GAC>AAC	p.D671N	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.D655N|PHACTR4_uc001bpy.2_Missense_Mutation_p.D681N|PHACTR4_uc001bpz.2_RNA	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	671							actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		GACCCCTGCTGACAAGGTACC	0.368													0	0	0	0.009096	0	3	63										A	28818294	G	A	28818294	3	1	60	1	0	0	0	0	1	0	0	0	11812	1290	45	1	2103	1	PHACTR4	1	28818294	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	1186612	28818294	220432327	8	17277										
CSMD2	114784	broad.mit.edu	37	chr1	34166245	34166245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggctaaaaactcccagcaaaCgggcggagttgttgttgcca	12	10	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:34166245C>T	uc001bxn.1	-	23	3514	c.3485G>A	c.(3484-3486)CGT>CAT	p.R1162H	CSMD2_uc001bxm.1_Missense_Mutation_p.R1202H|CSMD2_uc001bxo.1_Missense_Mutation_p.R75H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1162	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TCCCAGCAAACGGGCGGAGTT	0.498													0	0	0	0.076483	0	20	52										T	34166245	C	T	34166245	3	4	60	1	0	0	0	0	1	0	0	0	3945	536	19	2	7166	2	CSMD2	1	34166245	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	5347951	34166245	215084376	9	17278										
UTP11L	51118	broad.mit.edu	37	chr1	38484964	38484964	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aactcacctgcaaacagcccCggagctagtcgacagagtct	9	14	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:38484964C>T	uc001ccn.3	+	6	567	c.476C>T	c.(475-477)CCG>CTG	p.P159L	UTP11L_uc009vvm.2_Missense_Mutation_p.P90L|UTP11L_uc010oil.1_Intron|UTP11L_uc001cco.3_Missense_Mutation_p.P90L	NM_016037	NP_057121	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar	159					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CAAACAGCCCCGGAGCTAGTC	0.433													0	0	0	0.099896	0	25	115										T	38484964	C	T	38484964	3	4	60	1	0	0	0	0	1	0	0	0	17091	652	23	2	498	2	UTP11L	1	38484964	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	4318719	38484964	210765657	10	17279										
ELAVL4	1996	broad.mit.edu	37	chr1	50642770	50642770	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tatttccacaggacagagttTagggtatggatttgttaact	10	5	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:50642770T>G	uc001csb.2	+	3	528	c.260T>G	c.(259-261)TTA>TGA	p.L87*	ELAVL4_uc001cry.3_Nonsense_Mutation_p.L90*|ELAVL4_uc001crz.3_Nonsense_Mutation_p.L87*|ELAVL4_uc001csa.3_Nonsense_Mutation_p.L104*|ELAVL4_uc001csc.3_Nonsense_Mutation_p.L87*|ELAVL4_uc009vyu.2_Nonsense_Mutation_p.L92*|ELAVL4_uc010omz.1_Nonsense_Mutation_p.L92*	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	87	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GGACAGAGTTTAGGGTATGGA	0.264													0	0	0	0.014758	0	5	29										G	50642770	T	G	50642770	4	3	60	1	0	0	0	0	0	1	0	0	5052	1764	61	5	369	5	ELAVL4	1	50642770	Nonsense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	12157806	50642770	198607851	11	17280										
PGM1	5236	broad.mit.edu	37	chr1	64095755	64095755	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gaaaataagttcaaacccttCacaggcatgtttactttcct	5	10	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:64095755C>T	uc001dbh.2	+	3	765	c.552C>T	c.(550-552)TTC>TTT	p.F184F	PGM1_uc010ooy.1_5'UTR|PGM1_uc010ooz.1_Silent_p.F202F	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	184					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						TCAAACCCTTCACAGGCATGT	0.428													0	0	0	0.038147	0	7	83										T	64095755	C	T	64095755	2	4	60	1	0	0	0	0	0	0	0	1	11797	825	29	1		1	PGM1	1	64095755	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	13452985	64095755	185154866	12	17281										
ATP1A1	476	broad.mit.edu	37	chr1	116931580	116931580	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cagactaggtctccagatttCacaaatgaaaaccccctgga	7	12	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:116931580C>T	uc001ege.2	+	7	1032	c.693C>T	c.(691-693)TTC>TTT	p.F231F	ATP1A1_uc010owv.1_Silent_p.F200F|ATP1A1_uc010oww.1_Silent_p.F231F|ATP1A1_uc010owx.1_Silent_p.F200F	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	231	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	CTCCAGATTTCACAAATGAAA	0.443													0	0	0	0.021553	0	5	60										T	116931580	C	T	116931580	2	4	60	1	0	0	0	0	0	0	0	1	1128	825	29	1		1	ATP1A1	1	116931580	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	52835825	116931580	132319041	13	17282										
RIT1	6016	broad.mit.edu	37	chr1	155874559	155874561	+	In_Frame_Del	DEL	TCA	TCA	-													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaatgtccagattggcaggcTcatcatcaatacggatcctg							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:155874559_155874561delTCA	uc001fmh.1	-	4	385_387	c.198_200delTGA	c.(196-201)GATGAG>GAG	p.D66del	RIT1_uc010pgr.1_In_Frame_Del_p.D30del	NM_006912	NP_008843	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	66					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			ATTGGCAGGCTCATCATCAATAC	0.409																		11	100	---	---								-	155874561	TCA	-	155874559	7	5	60	1	0	1	0	1	0	0	0	0	13386	1551	54	0	471	0	RIT1	1	155874559	In_Frame_Del	DEL	TCA	TCGA-DK-A3IQ-01A-31D-A20D-08	38942979	155874559	93376062	14	17283										
ATF6	22926	broad.mit.edu	37	chr1	161823073	161823073	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agtagaaaggaccaagtcaaGaagaatgacaaataatcaac	8	6	2	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:161823073G>A	uc001gbr.2	+	12	1560	c.1493G>A	c.(1492-1494)AGA>AAA	p.R498K	ATF6_uc001gbq.1_Missense_Mutation_p.R498K	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	498	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			ACCAAGTCAAGAAGAATGACA	0.313													0	0	0	0.004672	0	3	32										A	161823073	G	A	161823073	3	1	60	1	0	0	0	0	1	0	0	0	1084	942	33	1	1539	1	ATF6	1	161823073	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	5948514	161823073	87427548	15	17284										
F5	2153	broad.mit.edu	37	chr1	169512142	169512142	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttcctaatgctgcagccagtCtgttctggtaatcatagtca	8	10	4	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:169512142C>G	uc001ggg.1	-	13	2331	c.2186G>C	c.(2185-2187)AGA>ACA	p.R729T		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	729	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGCAGCCAGTCTGTTCTGGTA	0.433													0	0	0	0.069456	0	34	182										G	169512142	C	G	169512142	3	3	60	1	0	0	0	0	1	0	0	0	5348	913	32	1	4540	1	F5	1	169512142	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	7689069	169512142	79738479	16	17285										
EXOC8	149371	broad.mit.edu	37	chr1	231471422	231471422	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acaccttcttcaaaccttttCtccaccacagggaggactgt	6	14	3	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr1:231471422C>G	uc001huq.2	-	1	2157	c.2070G>C	c.(2068-2070)GAG>GAC	p.E690D		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	690					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				CAAACCTTTTCTCCACCACAG	0.423													0	0	0	0.069456	0	30	130										G	231471422	C	G	231471422	3	3	60	1	0	0	0	0	1	0	0	0	5311	912	32	1	111	1	EXOC8	1	231471422	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	61959280	231471422	17779199	17	17286										
GRHL1	29841	broad.mit.edu	37	chr2	10136044	10136044	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggccgtacggcacagaagatGactttgctgtccctccttct	10	13	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:10136044G>A	uc002raa.2	+	13	1708	c.1537G>A	c.(1537-1539)GAC>AAC	p.D513N	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.D324N|GRHL1_uc010yjb.1_Missense_Mutation_p.D362N	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	513					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CACAGAAGATGACTTTGCTGT	0.458													0	0	0	0.064281	0	30	202										A	10136044	G	A	10136044	3	1	60	1	0	0	0	0	1	0	0	0	6763	1290	45	1	1587	1	GRHL1	2	10136044	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		10136044	233063329	18	17287										
PLB1	151056	broad.mit.edu	37	chr2	28801013	28801013	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aggaggctggtggacctgatGaagaatgacacggtgggtcc	17	7	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:28801013G>A	uc002rmb.1	+	22	1473	c.1473G>A	c.(1471-1473)ATG>ATA	p.M491I	PLB1_uc010ezj.1_Missense_Mutation_p.M502I|PLB1_uc002rmc.2_Missense_Mutation_p.M179I|PLB1_uc002rmd.1_Missense_Mutation_p.M1I	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	491	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					TGGACCTGATGAAGAATGACA	0.582													0	0	0	0.014758	0	4	58										A	28801013	G	A	28801013	3	1	60	1	0	0	0	0	1	0	0	0	12024	1290	45	1	1592	1	PLB1	2	28801013	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	18664969	28801013	214398360	19	17288										
XDH	7498	broad.mit.edu	37	chr2	31572693	31572693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctttgtacaggttttttctcCgcaccttcccaaggagagag	9	11	1	1	rs138396004		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:31572693C>T	uc002rnv.1	-	26	2907	c.2828G>A	c.(2827-2829)CGG>CAG	p.R943Q		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	943					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GTTTTTTCTCCGCACCTTCCC	0.542													0	0	0	0.014758	0	4	54										T	31572693	C	T	31572693	3	4	60	1	0	0	0	0	1	0	0	0	17423	652	23	2	1217	2	XDH	2	31572693	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2771680	31572693	211626680	20	17289										
DYNC2LI1	51626	broad.mit.edu	37	chr2	44036863	44036863	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggaactggaacagtacaaaaGaagttcttccaagtcttgga	10	7	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:44036863G>C	uc002rtk.2	+	13	1109	c.1013G>C	c.(1012-1014)AGA>ACA	p.R338T	DYNC2LI1_uc002rtl.2_Missense_Mutation_p.R339T|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.R212T	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	338						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAGTACAAAAGAAGTTCTTCC	0.284													0	0	0	0.058154	0	5	22										C	44036863	G	C	44036863	3	2	60	1	0	0	0	0	1	0	0	0	4847	942	33	1	1174	1	DYNC2LI1	2	44036863	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	12464170	44036863	199162510	21	17290										
DYNC2LI1	51626	broad.mit.edu	37	chr2	44036898	44036898	+	Missense_Mutation	SNP	G	G	C													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cttggaaacaaatcgagcttGattcttgaacctatttcaat							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:44036898G>C	uc002rtk.2	+	13	1144	c.1048G>C	c.(1048-1050)GAT>CAT	p.D350H	DYNC2LI1_uc002rtl.2_Missense_Mutation_p.D351H|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.D224H	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	350						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AATCGAGCTTGATTCTTGAAC	0.269													0	0	0	0.02938	0	3	13										C	44036898	G	C	44036898	3	2	60	1	0	0	0	0	1	0	0	0	4847	1290	45	1	1209	1	DYNC2LI1	2	44036898	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	35	44036898	199162475	22	17291	83	2								
DYNC2LI1	51626	broad.mit.edu	37	chr2	44036905	44036905	+	Silent	SNP	G	G	A													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acaaatcgagcttgattcttGaacctatttcaattattgta							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:44036905G>A	uc002rtk.2	+	13	1151	c.1055G>A	c.(1054-1056)TGA>TAA	p.*352*	DYNC2LI1_uc002rtl.2_Silent_p.*353*|DYNC2LI1_uc010ynz.1_Silent_p.*226*	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	352						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTTGATTCTTGAACCTATTTC	0.274													0	0	0	0.02938	0	4	13										A	44036905	G	A	44036905	2	1	60	1	0	0	0	0	0	0	0	1	4847	1285	45	1		1	DYNC2LI1	2	44036905	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	7	44036905	199162468	23	17292	83	2								
ABCG5	64240	broad.mit.edu	37	chr2	44040419	44040419	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttgagtgaaggcacacattgGattagttgtcacagaaacat	10	6	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:44040419G>A	uc002rtn.2	-	13	1932	c.1792C>T	c.(1792-1794)CCA>TCA	p.P598S	ABCG5_uc002rtm.2_Missense_Mutation_p.P203S|ABCG5_uc002rto.2_Missense_Mutation_p.P427S|ABCG5_uc002rtp.2_Missense_Mutation_p.P203S	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	598	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GCACACATTGGATTAGTTGTC	0.338													0	0	0	0.080935	0	9	29										A	44040419	G	A	44040419	3	1	60	1	0	0	0	0	1	0	0	0	71	1174	41	1	167	1	ABCG5	2	44040419	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3514	44040419	199158954	24	17293										
SPTBN1	6711	broad.mit.edu	37	chr2	54876994	54876994	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aagttttaccacgatgccaaGgagatctttgggcgtataca	10	8	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:54876994G>A	uc002rxu.2	+	26	5694	c.5445G>A	c.(5443-5445)AAG>AAA	p.K1815K	SPTBN1_uc002rxx.2_Silent_p.K1802K|SPTBN1_uc002rxy.2_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1815	Interaction with ANK2.|Spectrin 15.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACGATGCCAAGGAGATCTTTG	0.493													0	0	0	0.080935	0	11	51										A	54876994	G	A	54876994	2	1	60	1	0	0	0	0	0	0	0	1	15118	991	35	2		2	SPTBN1	2	54876994	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	10836575	54876994	188322379	25	17294										
RAB11FIP5	26056	broad.mit.edu	37	chr2	73315528	73315528	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aggactttagcctgagcactCagctcctcctgtccaagcac	8	15	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:73315528C>G	uc002siu.3	-	3	1459	c.1218G>C	c.(1216-1218)CTG>CTC	p.L406L	RAB11FIP5_uc002sit.3_Silent_p.L328L	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	406					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CCTGAGCACTCAGCTCCTCCT	0.657													0	0	0	0.028581	0	14	53										G	73315528	C	G	73315528	2	3	60	1	0	0	0	0	0	0	0	1	12897	813	29	1		1	RAB11FIP5	2	73315528	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	18438534	73315528	169883845	26	17295										
VWA3B	200403	broad.mit.edu	37	chr2	98744726	98744726	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aatccatttactactttgtgGtgggggatgttcctgaagaa	11	6	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:98744726G>A	uc002syo.2	+	6	991	c.727G>A	c.(727-729)GTG>ATG	p.V243M	VWA3B_uc010yvh.1_Missense_Mutation_p.V93M|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Missense_Mutation_p.V243M|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	243										ovary(3)|large_intestine(2)|skin(1)	6						CTACTTTGTGGTGGGGGATGT	0.498													0	0	0	0.045705	0	31	106										A	98744726	G	A	98744726	3	1	60	1	0	0	0	0	1	0	0	0	17238	1261	44	2	745	2	VWA3B	2	98744726	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	25429198	98744726	144454647	27	17296										
TUBA3E	112714	broad.mit.edu	37	chr2	130951802	130951802	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtcatagatggcttcattgtCgaccatgaaggcacagtcag	11	9	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:130951802C>T	uc002tqv.2	-	4	714	c.613G>A	c.(613-615)GAC>AAC	p.D205N		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	205					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					GCTTCATTGTCGACCATGAAG	0.552													0	0	0	0.09319	0	9	62										T	130951802	C	T	130951802	3	4	60	1	0	0	0	0	1	0	0	0	16745	884	31	1	747	1	TUBA3E	2	130951802	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	32207076	130951802	112247571	28	17297										
LOC150786	150786	broad.mit.edu	37	chr2	132120876	132120876	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttggctttcctctctccctCctcaattgacacttgcctct	4	16	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:132120876C>G	uc002tsr.2	-	1	856	c.418G>C	c.(418-420)GAG>CAG	p.E140Q		NM_001077637	NP_001071105	Q53S08	Q53S08_HUMAN	RAB6C-like	140					protein transport|small GTPase mediated signal transduction		GTP binding				0				BRCA - Breast invasive adenocarcinoma(221;0.078)		CTCTCTCCCTCCTCAATTGAC	0.438													0	0	0	0.058154	0	9	231										G	132120876	C	G	132120876	3	3	60	1	0	0	0	0	1	0	0	0	8870	864	30	1	350	1	LOC150786	2	132120876	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1169074	132120876	111078497	29	17298										
TUBA3D	113457	broad.mit.edu	37	chr2	132237879	132237879	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctgactgtgccttcatggtcGacaatgaagccatctatgac	9	11	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:132237879G>A	uc002tsu.3	+	4	720	c.613G>A	c.(613-615)GAC>AAC	p.D205N		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	205					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTTCATGGTCGACAATGAAGC	0.557													0	0	0	0.055883	0	8	130										A	132237879	G	A	132237879	3	1	60	1	0	0	0	0	1	0	0	0	16744	1058	37	1	627	1	TUBA3D	2	132237879	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	117003	132237879	110961494	30	17299										
SCN1A	6323	broad.mit.edu	37	chr2	166848189	166848189	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtaaaagcaaataagatatCaagacagtggatccggtcac	9	7	2	2	rs121918815		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:166848189C>A	uc010zcz.1	-	26	5581	c.5563G>T	c.(5563-5565)GAT>TAT	p.D1855Y		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1866						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATAAGATATCAAGACAGTGG	0.483													1	0	2.17888e-05	0.058154	2.3303e-05	10	79										A	166848189	C	A	166848189	3	1	60	1	0	0	0	0	1	0	0	0	13914	826	29	3	437	3	SCN1A	2	166848189	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	34610310	166848189	76351184	31	17300										
PHOSPHO2	493911	broad.mit.edu	37	chr2	170557854	170557854	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttgataaagtgtttacaaatCcagcagcttttaatagcaat	6	6	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:170557854C>T	uc002ufg.2	+	4	761	c.373C>T	c.(373-375)CCA>TCA	p.P125S	KLHL23_uc002ufh.1_Intron	NM_001008489	NP_001008489	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	125							metal ion binding|pyridoxal phosphatase activity			skin(1)	1						GTTTACAAATCCAGCAGCTTT	0.323													0	0	0	0.02938	0	6	34										T	170557854	C	T	170557854	3	4	60	1	0	0	0	0	1	0	0	0	11857	855	30	1	375	1	PHOSPHO2	2	170557854	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	3709665	170557854	72641519	32	17301										
GAD1	2571	broad.mit.edu	37	chr2	171710417	171710417	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atgcaaccagatgtgtgcagGatacctcttccagccagaca	9	12	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:171710417G>C	uc002ugi.2	+	14	1720	c.1298G>C	c.(1297-1299)GGA>GCA	p.G433A	GAD1_uc010fqc.2_Missense_Mutation_p.G52A	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	433					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATGTGTGCAGGATACCTCTTC	0.483													0	0	0	0.038147	0	6	120										C	171710417	G	C	171710417	3	2	60	1	0	0	0	0	1	0	0	0	6179	1174	41	1	1389	1	GAD1	2	171710417	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	1152563	171710417	71488956	33	17302										
TTN	7273	broad.mit.edu	37	chr2	179575377	179575377	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gataccttttatattcagctGagctgtgcaagagtcttttc	8	8	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:179575377G>A	uc010zfg.1	-	95	24939	c.24715C>T	c.(24715-24717)CAG>TAG	p.Q8239*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.Q4900*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9166							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTCAGCTGAGCTGTGCAA	0.398													0	0	0	0.080935	0	10	110										A	179575377	G	A	179575377	4	1	60	1	0	0	0	0	0	1	0	0	16732	1299	45	1	76142	1	TTN	2	179575377	Nonsense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	7864960	179575377	63623996	34	17303										
FRZB	2487	broad.mit.edu	37	chr2	183703267	183703267	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtttaccagagaggactttaGaatctccttcacctccacta	6	12	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:183703267G>C	uc002upa.1	-	4	885	c.667C>G	c.(667-669)CTA>GTA	p.L223V		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	223	NTR.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GAGGACTTTAGAATCTCCTTC	0.433													0	0	0	0.069288	0	21	99										C	183703267	G	C	183703267	3	2	60	1	0	0	0	0	1	0	0	0	6065	933	33	1	322	1	FRZB	2	183703267	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	4127890	183703267	59496106	35	17304										
COL5A2	1290	broad.mit.edu	37	chr2	189909924	189909924	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	caggtaatccacgtttcccaGctcgaccaggtggtcctata	9	13	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:189909924G>C	uc002uqk.2	-	47	3619	c.3344C>G	c.(3343-3345)GCT>GGT	p.A1115G	COL5A2_uc010frx.2_Missense_Mutation_p.A691G	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1115					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ACGTTTCCCAGCTCGACCAGG	0.299													0	0	0	0.047766	0	5	27										C	189909924	G	C	189909924	3	2	60	1	0	0	0	0	1	0	0	0	3697	971	34	4	1187	4	COL5A2	2	189909924	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6206657	189909924	53289449	36	17305										
ORMDL1	94101	broad.mit.edu	37	chr2	190640311	190640311	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agaattattggagaaattgtGaaaaacttccgtgaagatgt	10	3	0	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:190640311G>A	uc002urb.3	-	2	1093	c.306C>T	c.(304-306)TTC>TTT	p.F102F	ORMDL1_uc002urc.3_Silent_p.F102F|ORMDL1_uc002urd.3_Silent_p.F102F|ORMDL1_uc002ure.3_Silent_p.F102F|ORMDL1_uc002urf.3_Silent_p.F102F	NM_016467	NP_057551	Q9P0S3	ORML1_HUMAN	ORM1-like 1	102	Helical; (Potential).				ceramide metabolic process	endoplasmic reticulum membrane|integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(117;0.00177)|Epithelial(96;0.0317)|all cancers(119;0.0889)			GAGAAATTGTGAAAAACTTCC	0.383													0	0	0	0.014758	0	4	34										A	190640311	G	A	190640311	2	1	60	1	0	0	0	0	0	0	0	1	11269	1281	45	1		1	ORMDL1	2	190640311	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	730387	190640311	52559062	37	17306										
SGOL2	151246	broad.mit.edu	37	chr2	201400832	201400832	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gctctcatgaacaataacttGataactgcaattgaaatgag	7	7	1	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:201400832G>C	uc002uvw.2	+	4	467	c.354G>C	c.(352-354)TTG>TTC	p.L118F	SGOL2_uc002uvv.3_Missense_Mutation_p.L118F|SGOL2_uc010zhd.1_Missense_Mutation_p.L118F|SGOL2_uc010zhe.1_Missense_Mutation_p.L118F	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	118					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						ACAATAACTTGATAACTGCAA	0.294													0	0	0	0.038147	0	8	82										C	201400832	G	C	201400832	3	2	60	1	0	0	0	0	1	0	0	0	14217	1281	45	1	364	1	SGOL2	2	201400832	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	10760521	201400832	41798541	38	17307										
GIGYF2	26058	broad.mit.edu	37	chr2	233655998	233655998	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggaaactccccagacctcatCatcatctgctagaccaggta	7	14	4	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr2:233655998C>A	uc002vti.3	+	14	1461	c.1124C>A	c.(1123-1125)TCA>TAA	p.S375*	GIGYF2_uc010zmj.1_Nonsense_Mutation_p.S375*|GIGYF2_uc002vtg.2_Nonsense_Mutation_p.S369*|GIGYF2_uc002vtj.3_Nonsense_Mutation_p.S396*|GIGYF2_uc002vtk.3_Nonsense_Mutation_p.S375*|GIGYF2_uc002vth.3_Nonsense_Mutation_p.S369*|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Nonsense_Mutation_p.S206*	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	375					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CAGACCTCATCATCATCTGCT	0.428													1	0	0.00074312	0.038395	0.000773851	14	62										A	233655998	C	A	233655998	4	1	60	1	0	0	0	0	0	1	0	0	6378	838	29	3	1232	3	GIGYF2	2	233655998	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	32255166	233655998	9543375	39	17308										
SETD5	55209	broad.mit.edu	37	chr3	9482170	9482170	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctgaagcacagaatttagatGagaatacaactgagggctgg	12	6	0	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:9482170G>A	uc003brt.2	+	8	1033	c.598G>A	c.(598-600)GAG>AAG	p.E200K	SETD5_uc003brs.1_Missense_Mutation_p.E181K|SETD5_uc003bru.2_Missense_Mutation_p.E102K|SETD5_uc003brv.2_Missense_Mutation_p.E89K|SETD5_uc010hck.2_5'Flank|SETD5_uc003brw.1_5'Flank|SETD5_uc003brx.2_5'Flank	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	200										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		GAATTTAGATGAGAATACAAC	0.433													0	0	0	0.02938	0	7	18										A	9482170	G	A	9482170	3	1	60	1	0	0	0	0	1	0	0	0	14134	1291	45	1	620	1	SETD5	3	9482170	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		9482170	188540260	40	17309										
WNT7A	7476	broad.mit.edu	37	chr3	13916516	13916516	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccagcggccattgcggaactGaaactgacactcgtccaggc	11	14	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:13916516G>A	uc003bye.1	-	2	531	c.226C>T	c.(226-228)CAG>TAG	p.Q76*		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	76					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						TTGCGGAACTGAAACTGACAC	0.617													0	0	0	0.058154	0	9	59										A	13916516	G	A	13916516	4	1	60	1	0	0	0	0	0	1	0	0	17391	1299	45	1	835	1	WNT7A	3	13916516	Nonsense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	4434346	13916516	184105914	41	17310										
ZNF660	285349	broad.mit.edu	37	chr3	44636265	44636265	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaaaagtttacaaatgtaagGagtgtgggaaaacatgtggt	12	2	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:44636265G>C	uc003cnl.1	+	3	913	c.580G>C	c.(580-582)GAG>CAG	p.E194Q		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	194	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		CAAATGTAAGGAGTGTGGGAA	0.393													0	0	0	0.020292	0	14	56										C	44636265	G	C	44636265	3	2	60	1	0	0	0	0	1	0	0	0	18067	1175	41	1	582	1	ZNF660	3	44636265	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	30719749	44636265	153386165	42	17311										
TGM4	7047	broad.mit.edu	37	chr3	44943347	44943347	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcgattcagctcacgacacaGaaaggaacctcacggtggac	10	12	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:44943347G>C	uc003coc.3	+	8	968	c.895G>C	c.(895-897)GAA>CAA	p.E299Q		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	299					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TCACGACACAGAAAGGAACCT	0.542													0	0	0	0.080935	0	11	57										C	44943347	G	C	44943347	3	2	60	1	0	0	0	0	1	0	0	0	15829	943	33	1	925	1	TGM4	3	44943347	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	307082	44943347	153079083	43	17312										
AMIGO3	386724	broad.mit.edu	37	chr3	49756011	49756011	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctggtgttgcagtaaagcctCagggaccgacccaccagcgc	12	14	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:49756011C>T	uc003cxj.2	-	1	1228	c.888G>A	c.(886-888)CTG>CTA	p.L296L	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	296	Extracellular (Potential).|Ig-like C2-type.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGTAAAGCCTCAGGGACCGAC	0.652													0	0	0	0.014758	0	5	22										T	49756011	C	T	49756011	2	4	60	1	0	0	0	0	0	0	0	1	577	813	29	1		1	AMIGO3	3	49756011	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	4812664	49756011	148266419	44	17313										
AMIGO3	386724	broad.mit.edu	37	chr3	49756493	49756494	+	Missense_Mutation	DNP	CC	CC	TT													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	attgaacagaagcagcttctCcagcgcccccagcccgtcga							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:49756493_49756494CC>TT	uc003cxj.2	-	1	745_746	c.405_406GG>AA	c.(403-408)CTGGAG>CTAAAG	p.E136K	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	136	Extracellular (Potential).|LRR 4.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGCAGCTTCTCCAGCGCCCCCA	0.634											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	25	85										TT	49756494	CC	TT	49756493	3	4	60	1	0	0	0	0	1	0	0	0	577	864	30	1	1112	1	AMIGO3	3	49756493	Missense_Mutation	DNP	CC	TCGA-DK-A3IQ-01A-31D-A20D-08	482	49756493	148265937	45	17314										
PROS1	5627	broad.mit.edu	37	chr3	93611862	93611862	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	taagctgaacttcaatctttCcaccacgaagtgcaatcagg	7	11	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:93611862C>A	uc003drb.3	-	10	1411	c.1070G>T	c.(1069-1071)GGA>GTA	p.G357V	PROS1_uc010hoo.2_Missense_Mutation_p.G226V|PROS1_uc003dqz.3_Missense_Mutation_p.G226V	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	357	Laminin G-like 1.		G -> R (in PROS1D).		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTCAATCTTTCCACCACGAAG	0.403													1	0	0.00198382	0.02938	0.00205044	7	66										A	93611862	C	A	93611862	3	1	60	1	0	0	0	0	1	0	0	0	12558	855	30	3	984	3	PROS1	3	93611862	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	43855369	93611862	104410568	46	17315										
C3orf26	84319	broad.mit.edu	37	chr3	99881261	99881261	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcttggtgattgaattagaaGaactgaacctgccaggtata	11	6	0	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:99881261G>A	uc003dtl.2	+	4	483	c.340G>A	c.(340-342)GAA>AAA	p.E114K		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	114							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						TGAATTAGAAGAACTGAACCT	0.408													0	0	0	0.047766	0	7	30										A	99881261	G	A	99881261	3	1	60	1	0	0	0	0	1	0	0	0	2218	943	33	1	368	1	C3orf26	3	99881261	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6269399	99881261	98141169	47	17316										
HHLA2	11148	broad.mit.edu	37	chr3	108076964	108076964	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggaatatttatgcaatatttCttcggatgaatatactttac	6	5	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:108076964C>G	uc003dwy.3	+	6	1126	c.959C>G	c.(958-960)TCT>TGT	p.S320C	HHLA2_uc011bhl.1_Missense_Mutation_p.S256C|HHLA2_uc010hpu.2_Missense_Mutation_p.S320C|HHLA2_uc003dwz.2_Missense_Mutation_p.S320C	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	320	Ig-like V-type 2.					integral to membrane				ovary(1)	1						TGCAATATTTCTTCGGATGAA	0.378													0	0	0	0.004672	0	3	63										G	108076964	C	G	108076964	3	3	60	1	0	0	0	0	1	0	0	0	7095	913	32	1	973	1	HHLA2	3	108076964	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	8195703	108076964	89945466	48	17317										
CASR	846	broad.mit.edu	37	chr3	121980624	121980624	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aactcatctcccagtactctGatgaggaagagatccagcat	8	11	3	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:121980624G>A	uc003eev.3	+	4	1114	c.742G>A	c.(742-744)GAT>AAT	p.D248N	CASR_uc003eew.3_Missense_Mutation_p.D248N	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	248	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCAGTACTCTGATGAGGAAGA	0.502													0	0	0	0.038147	0	5	207										A	121980624	G	A	121980624	3	1	60	1	0	0	0	0	1	0	0	0	2682	1290	45	1	752	1	CASR	3	121980624	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	13903660	121980624	76041806	49	17318										
SEMA5B	54437	broad.mit.edu	37	chr3	122667459	122667459	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aggtgggacaccagcagtgtGaggctgggcagcaacagcga	17	9	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:122667459G>A	uc003efz.1	-	3	526	c.222C>T	c.(220-222)CTC>CTT	p.L74L	SEMA5B_uc011bju.1_Silent_p.L16L|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.L74L|SEMA5B_uc010hro.1_Silent_p.L16L|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	74	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CCAGCAGTGTGAGGCTGGGCA	0.647													0	0	0	0.069234	0	10	29										A	122667459	G	A	122667459	2	1	60	1	0	0	0	0	0	0	0	1	14038	1277	45	1		1	SEMA5B	3	122667459	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	686835	122667459	75354971	50	17319										
PLXND1	23129	broad.mit.edu	37	chr3	129290522	129290522	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcggggtgccagtctcacctGacagggctgcggcggggact	18	12	1	1	rs111780083		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:129290522G>C	uc003emx.2	-	16	3343	c.3243C>G	c.(3241-3243)GTC>GTG	p.V1081V		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1081	Extracellular (Potential).|IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AGTCTCACCTGACAGGGCTGC	0.657													0	0	0	0.076483	0	19	95										C	129290522	G	C	129290522	2	2	60	1	0	0	0	0	0	0	0	1	12127	1277	45	1		1	PLXND1	3	129290522	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6623063	129290522	68731908	51	17320										
DBR1	51163	broad.mit.edu	37	chr3	137888979	137888979	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttatagacttcaatatttctCacatgatatatactcctgat	3	8	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:137888979C>G	uc003erv.2	-	4	595	c.459G>C	c.(457-459)GTG>GTC	p.V153V	DBR1_uc003eru.2_Silent_p.V102V	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	153						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						CAATATTTCTCACATGATATA	0.299													0	0	0	0.09319	0	12	77										G	137888979	C	G	137888979	2	3	60	1	0	0	0	0	0	0	0	1	4257	813	29	1		1	DBR1	3	137888979	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	8598457	137888979	60133451	52	17321										
YEATS2	55689	broad.mit.edu	37	chr3	183442274	183442274	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgatctcacagatgagacttCacgactttttgtaaagaaaa	7	7	2	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr3:183442274C>T	uc003fly.2	+	6	800	c.605C>T	c.(604-606)TCA>TTA	p.S202L		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	202					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GATGAGACTTCACGACTTTTT	0.343													0	0	0	0.021553	0	6	39										T	183442274	C	T	183442274	3	4	60	1	0	0	0	0	1	0	0	0	17469	838	29	1	623	1	YEATS2	3	183442274	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	45553295	183442274	14580156	53	17322										
MFSD10	10227	broad.mit.edu	37	chr4	2934873	2934873	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggcgcctccccaagcagtcaGaggtggccccagtgagtggc	15	14	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr4:2934873G>C	uc003gfw.2	-	3	646	c.332C>G	c.(331-333)TCT>TGT	p.S111C	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_5'UTR|MFSD10_uc003gfz.2_Missense_Mutation_p.S111C|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Missense_Mutation_p.S111C|MFSD10_uc003ggb.1_Missense_Mutation_p.S111C|MFSD10_uc003ggc.2_Missense_Mutation_p.S111C|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank|C4orf10_uc003ggg.1_5'Flank|C4orf10_uc003ggh.2_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	111					apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CAAGCAGTCAGAGGTGGCCCC	0.632													0	0	0	0.038147	0	5	28										C	2934873	G	C	2934873	3	2	60	1	0	0	0	0	1	0	0	0	9528	942	33	1	1075	1	MFSD10	4	2934873	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		2934873	188219403	54	17323										
MFSD10	10227	broad.mit.edu	37	chr4	2934901	2934901	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cccagtgagtggcgcacacaGaaactgcaggacagagaatg	13	10	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr4:2934901G>A	uc003gfw.2	-	3	618	c.304C>T	c.(304-306)CTG>TTG	p.L102L	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_5'UTR|MFSD10_uc003gfz.2_Silent_p.L102L|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Silent_p.L102L|MFSD10_uc003ggb.1_Silent_p.L102L|MFSD10_uc003ggc.2_Silent_p.L102L|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank|C4orf10_uc003ggg.1_5'Flank|C4orf10_uc003ggh.2_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	102	Helical; (Potential).				apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGCGCACACAGAAACTGCAGG	0.617													0	0	0	0.009096	0	3	31										A	2934901	G	A	2934901	2	1	60	1	0	0	0	0	0	0	0	1	9528	933	33	1		1	MFSD10	4	2934901	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	28	2934901	188219375	55	17324										
SHISA3	152573	broad.mit.edu	37	chr4	42403249	42403249	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cggcagtccagcacagccacGagctccagctccacaggcgg	12	17	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr4:42403249G>C	uc003gwp.2	+	2	716	c.498G>C	c.(496-498)ACG>ACC	p.T166T		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	166	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						GCACAGCCACGAGCTCCAGCT	0.672													0	0	0	0.028581	0	16	116										C	42403249	G	C	42403249	2	2	60	1	0	0	0	0	0	0	0	1	14281	1045	37	1		1	SHISA3	4	42403249	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	39468348	42403249	148751027	56	17325										
FAT4	79633	broad.mit.edu	37	chr4	126237764	126237764	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctggtaggcaccatccagacGcgccccggcttcacctacag	10	17	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr4:126237764G>C	uc003ifj.3	+	1	198	c.198G>C	c.(196-198)ACG>ACC	p.T66T		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	66	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCATCCAGACGCGCCCCGGCT	0.647											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014758	0	4	30										C	126237764	G	C	126237764	2	2	60	1	0	0	0	0	0	0	0	1	5692	1074	38	4		4	FAT4	4	126237764	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	83834515	126237764	64916512	57	17326										
FAT1	2195	broad.mit.edu	37	chr4	187557747	187557747	+	Frame_Shift_Del	DEL	T	T	-													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atcttaactcactgaaagaaTatcatattctccagctgctg							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr4:187557747delT	uc003izf.2	-	5	4152	c.3964delA	c.(3964-3966)ATTfs	p.I1322fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1322	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ACTGAAAGAATATCATATTCT	0.338										HNSCC(5;0.00058)								14	300	---	---								-	187557747	T	-	187557747	7	5	60	1	0	1	0	1	0	0	0	0	5689	1406	49	0	9894	0	FAT1	4	187557747	Frame_Shift_Del	DEL	T	TCGA-DK-A3IQ-01A-31D-A20D-08	61319983	187557747	3596529	58	17327										
TAS2R1	50834	broad.mit.edu	37	chr5	9629539	9629539	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctcatttgccgggtgtgcctCcccagagagaaaatcaagag	11	11	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:9629539C>T	uc003jem.1	-	1	925	c.606G>A	c.(604-606)GGG>GGA	p.G202G		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	202	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						GGGTGTGCCTCCCCAGAGAGA	0.502													0	0	0	0.069234	0	10	31										T	9629539	C	T	9629539	2	4	60	1	0	0	0	0	0	0	0	1	15562	842	30	1		1	TAS2R1	5	9629539	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		9629539	171285721	59	17328										
UGT3A2	167127	broad.mit.edu	37	chr5	36049133	36049133	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gaagatgagacaaaactggcCtagagccttctgtgaaatgt	11	7	1	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:36049133C>G	uc003jjz.1	-	4	794	c.701G>C	c.(700-702)AGG>ACG	p.R234T	UGT3A2_uc011cos.1_Missense_Mutation_p.R200T|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	234	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAAAACTGGCCTAGAGCCTTC	0.418													0	0	0	0.0918	0	22	83										G	36049133	C	G	36049133	3	3	60	1	0	0	0	0	1	0	0	0	16961	681	24	4	886	4	UGT3A2	5	36049133	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	26419594	36049133	144866127	60	17329										
UGT3A2	167127	broad.mit.edu	37	chr5	36049523	36049523	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ataagttttcaaattttcctCtgtaagaaaaaaatgataat	4	4	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:36049523C>T	uc003jjz.1	-	4	405	c.312_splice	c.e4-1	p.R104_splice	UGT3A2_uc011cos.1_Splice_Site_p.R70_splice|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2							integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATTTTCCTCTGTAAGAAAA	0.284													0	0	0	0.014758	0	5	22										T	36049523	C	T	36049523	5	4	60	1	0	0	0	0	0	0	1	0	16961	927	32	1	1276	1	UGT3A2	5	36049523	Splice_Site	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	390	36049523	144865737	61	17330										
HCN1	348980	broad.mit.edu	37	chr5	45303768	45303768	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtaatgacaccagcaacaccGtgttgaatgaaatacatttt	7	8	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:45303768G>A	uc003jok.2	-	6	1576	c.1551C>T	c.(1549-1551)CAC>CAT	p.H517H		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	517	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CAGCAACACCGTGTTGAATGA	0.388													0	0	0	0.02938	0	7	69										A	45303768	G	A	45303768	2	1	60	1	0	0	0	0	0	0	0	1	6996	1136	40	2		2	HCN1	5	45303768	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	9254245	45303768	135611492	62	17331										
ITGA2	3673	broad.mit.edu	37	chr5	52361774	52361774	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggattccatcaccgatgtgtCtattggtgcctttggacaag	11	9	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:52361774C>T	uc003joy.2	+	15	2053	c.1910C>T	c.(1909-1911)TCT>TTT	p.S637F	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.S561F|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	637	FG-GAP 7.|Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				ACCGATGTGTCTATTGGTGCC	0.458													0	0	0	0.108266	0	21	91										T	52361774	C	T	52361774	3	4	60	1	0	0	0	0	1	0	0	0	7875	913	32	1	1968	1	ITGA2	5	52361774	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	7058006	52361774	128553486	63	17332										
RHOBTB3	22836	broad.mit.edu	37	chr5	95116086	95116086	+	Frame_Shift_Del	DEL	C	C	-													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggtgtttccaaagagactttCttgtcatttttagaatacct							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:95116086delC	uc003klm.2	+	9	1950	c.1413delC	c.(1411-1413)TTCfs	p.F471fs		NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	471	BTB 2.|Interaction with Rab9.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		AAGAGACTTTCTTGTCATTTT	0.418																		20	73	---	---								-	95116086	C	-	95116086	7	5	60	1	0	1	0	1	0	0	0	0	13335	912	32	0	1447	0	RHOBTB3	5	95116086	Frame_Shift_Del	DEL	C	TCGA-DK-A3IQ-01A-31D-A20D-08	42754312	95116086	85799174	64	17333										
APC	324	broad.mit.edu	37	chr5	112176224	112176224	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgccacgggtgtattgtgttGaagggacacctataaacttt	11	7	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:112176224G>C	uc010jby.2	+	16	5313	c.4933G>C	c.(4933-4935)GAA>CAA	p.E1645Q	APC_uc011cvt.1_Missense_Mutation_p.E1627Q|APC_uc003kpz.3_Missense_Mutation_p.E1645Q|APC_uc003kpy.3_Missense_Mutation_p.E1645Q|APC_uc010jbz.2_Missense_Mutation_p.E1362Q|APC_uc010jca.2_Missense_Mutation_p.E945Q	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1645	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1645Q(1)|p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GTATTGTGTTGAAGGGACACC	0.453		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			0	0	0	0.004672	0	3	73										C	112176224	G	C	112176224	3	2	60	1	0	0	0	0	1	0	0	0	763	1291	45	1	4991	1	APC	5	112176224	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	17060138	112176224	68739036	65	17334										
GRAMD3	65983	broad.mit.edu	37	chr5	125813438	125813438	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agaaaaccaaaactgctcttCtagtgccaaacgccctgatc	6	13	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:125813438C>A	uc003ktu.2	+	6	971	c.541C>A	c.(541-543)CTA>ATA	p.L181I	GRAMD3_uc011cwt.1_Missense_Mutation_p.L196I|GRAMD3_uc011cwv.1_Missense_Mutation_p.L189I|GRAMD3_uc011cww.1_Missense_Mutation_p.L77I|GRAMD3_uc011cwx.1_RNA|GRAMD3_uc011cwy.1_Missense_Mutation_p.L72I|GRAMD3_uc011cwz.1_Missense_Mutation_p.L165I|GRAMD3_uc011cwu.1_Missense_Mutation_p.L165I	NM_023927	NP_076416	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3 isoform 2	181										central_nervous_system(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		AACTGCTCTTCTAGTGCCAAA	0.478													1	0	3.28513e-13	0.0918	3.76025e-13	21	68										A	125813438	C	A	125813438	3	1	60	1	0	0	0	0	1	0	0	0	6751	912	32	3	777	3	GRAMD3	5	125813438	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	13637214	125813438	55101822	66	17335										
GDF9	2661	broad.mit.edu	37	chr5	132198223	132198223	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtaatgcgatccaggttaaaTagcagttccactgatggaag	11	7	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:132198223T>C	uc003kxz.1	-	2	675	c.423A>G	c.(421-423)CTA>CTG	p.L141L	GDF9_uc011cxj.1_Silent_p.L53L	NM_005260	NP_005251	O60383	GDF9_HUMAN	growth differentiation factor 9 precursor	141					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			skin(1)	1		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCAGGTTAAATAGCAGTTCCA	0.383													0	0	0	0.069234	0	11	29										C	132198223	T	C	132198223	2	2	60	1	0	0	0	0	0	0	0	1	6319	1393	49	5		5	GDF9	5	132198223	Silent	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	6384785	132198223	48717037	67	17336										
SEC24A	10802	broad.mit.edu	37	chr5	134023941	134023941	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	caatccatttctacggtcttCaggaaagtctctctcaacct	5	13	5	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:134023941C>T	uc003kzs.2	+	11	1963	c.1675C>T	c.(1675-1677)CAG>TAG	p.Q559*	SEC24A_uc011cxu.1_Nonsense_Mutation_p.Q323*	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	559					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTACGGTCTTCAGGAAAGTCT	0.313													0	0	0	0.024245	0	13	41										T	134023941	C	T	134023941	4	4	60	1	0	0	0	0	0	1	0	0	13994	827	29	1	1717	1	SEC24A	5	134023941	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1825718	134023941	46891319	68	17337										
PCDHA2	56146	broad.mit.edu	37	chr5	140175188	140175188	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gaggttaatttgttactggtGgctactgatgggggcaaacc	14	6	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:140175188G>T	uc003lhd.2	+	1	745	c.639G>T	c.(637-639)GTG>GTT	p.V213V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.V213V|PCDHA2_uc011czy.1_Silent_p.V213V	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	213	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTACTGGTGGCTACTGATG	0.428													1	0	7.92952e-12	0.0918	9.00196e-12	23	66										T	140175188	G	T	140175188	2	4	60	1	0	0	0	0	0	0	0	1	11524	1335	47	4		4	PCDHA2	5	140175188	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6151247	140175188	40740072	69	17338										
PCDHGA9	56107	broad.mit.edu	37	chr5	140782758	140782758	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcttttctctctgaacccgcGcagcggcaccttggtcaccg	10	16	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:140782758G>T	uc003lkh.1	+	1	239	c.239G>T	c.(238-240)CGC>CTC	p.R80L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.R80L	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	80	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAACCCGCGCAGCGGCACC	0.612													1	0	0.00307968	0.038147	0.00317127	8	37										T	140782758	G	T	140782758	3	4	60	1	0	0	0	0	1	0	0	0	11561	1087	38	4	241	4	PCDHGA9	5	140782758	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	607570	140782758	40132502	70	17339										
PCDHGA9	56107	broad.mit.edu	37	chr5	140782853	140782853	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	actttaaagtcctggttgaaGacagagtgaaactgtacgga	11	6	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:140782853G>C	uc003lkh.1	+	1	334	c.334G>C	c.(334-336)GAC>CAC	p.D112H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.D112H	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	112	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGTTGAAGACAGAGTGAA	0.507													0	0	0	0.049695	0	18	59										C	140782853	G	C	140782853	3	2	60	1	0	0	0	0	1	0	0	0	11561	942	33	1	336	1	PCDHGA9	5	140782853	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	95	140782853	40132407	71	17340										
SLIT3	6586	broad.mit.edu	37	chr5	168100246	168100246	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tggagcttccccaggctcttTggagttcctttgtccactac	9	13	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:168100246T>C	uc003mab.2	-	33	4197	c.3777A>G	c.(3775-3777)CCA>CCG	p.P1259P	SLIT3_uc010jjg.2_Silent_p.P1266P	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1259	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAGGCTCTTTGGAGTTCCTT	0.552													0	0	0	0.062417	0	19	60										C	168100246	T	C	168100246	2	2	60	1	0	0	0	0	0	0	0	1	14741	1799	63	5		5	SLIT3	5	168100246	Silent	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	27317393	168100246	12815014	72	17341										
NSD1	64324	broad.mit.edu	37	chr5	176696618	176696618	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cccaggtggtggccagctgaGatctgccatcctcgagctgt	13	13	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:176696618G>C	uc003mfr.3	+	16	5457	c.5319G>C	c.(5317-5319)GAG>GAC	p.E1773D	NSD1_uc003mft.3_Missense_Mutation_p.E1504D|NSD1_uc003mfs.1_Missense_Mutation_p.E1670D|NSD1_uc011dfx.1_Missense_Mutation_p.E1421D	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1773	PWWP 2.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGCCAGCTGAGATCTGCCATC	0.433			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.004672	0	3	48										C	176696618	G	C	176696618	3	2	60	1	0	0	0	0	1	0	0	0	10669	933	33	1	5377	1	NSD1	5	176696618	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	8596372	176696618	4218642	73	17342										
COL23A1	91522	broad.mit.edu	37	chr5	177690246	177690246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccctggggccatctttcccaGtgtcgccaggagggccccgg	14	16	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr5:177690246G>A	uc003mje.2	-	9	960	c.602C>T	c.(601-603)ACT>ATT	p.T201I	COL23A1_uc010jkt.2_Silent_p.L49L	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	201	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		ATCTTTCCCAGTGTCGCCAGG	0.647													0	0	0	0.069234	0	7	27										A	177690246	G	A	177690246	3	1	60	1	0	0	0	0	1	0	0	0	3682	1029	36	2	1104	2	COL23A1	5	177690246	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	993628	177690246	3225014	74	17343										
FOXF2	2295	broad.mit.edu	37	chr6	1390560	1390560	+	Silent	SNP	C	C	A													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cgcctgacgctcagcgagatCtaccagttcctgcaggcgcg							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:1390560C>A	uc003mtm.2	+	1	492	c.378C>A	c.(376-378)ATC>ATA	p.I126I	FOXF2_uc003mtn.2_Silent_p.I126I	NM_001452	NP_001443	Q12947	FOXF2_HUMAN	forkhead box F2	126	Fork-head.				epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		TCAGCGAGATCTACCAGTTCC	0.647													1	0	5.18039e-06	0.038147	5.60535e-06	8	28										A	1390560	C	A	1390560	2	1	60	1	0	0	0	0	0	0	0	1	6006	903	32	3		3	FOXF2	6	1390560	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		1390560	169724507	75	17344	84	2								
FOXF2	2295	broad.mit.edu	37	chr6	1390569	1390569	+	Missense_Mutation	SNP	C	C	A													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctcagcgagatctaccagttCctgcaggcgcgcttcccctt							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:1390569C>A	uc003mtm.2	+	1	501	c.387C>A	c.(385-387)TTC>TTA	p.F129L	FOXF2_uc003mtn.2_Missense_Mutation_p.F129L	NM_001452	NP_001443	Q12947	FOXF2_HUMAN	forkhead box F2	129	Fork-head.				epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		TCTACCAGTTCCTGCAGGCGC	0.632													1	0	3.59834e-05	0.021553	3.81892e-05	6	29										A	1390569	C	A	1390569	3	1	60	1	0	0	0	0	1	0	0	0	6006	854	30	3	389	3	FOXF2	6	1390569	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	9	1390569	169724498	76	17345	84	2								
MAK	4117	broad.mit.edu	37	chr6	10796367	10796367	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gctgctggctagtttttggcTggggttgtccaacaacctga	13	9	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:10796367T>G	uc003mzl.2	-	8	1236	c.1007A>C	c.(1006-1008)CAG>CCG	p.Q336P	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Missense_Mutation_p.Q336P|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	336	Glu/Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				AGTTTTTGGCTGGGGTTGTCC	0.502													0	0	0	0.047766	0	9	77										G	10796367	T	G	10796367	3	3	60	1	0	0	0	0	1	0	0	0	9197	1580	55	5	888	5	MAK	6	10796367	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	9405798	10796367	160318700	77	17346										
BTN3A3	10384	broad.mit.edu	37	chr6	26443857	26443857	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcaactttcatgtctccctcTtcttggtccagctgctcact	5	15	6	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:26443857T>C	uc003nhz.2	+	3	235	c.55T>C	c.(55-57)TTC>CTC	p.F19L	BTN3A3_uc003nia.2_Intron|BTN3A3_uc011dkn.1_Intron	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	19						integral to membrane					0						TGTCTCCCTCTTCTTGGTCCA	0.428													0	0	0	0.021553	0	5	52										C	26443857	T	C	26443857	3	2	60	1	0	0	0	0	1	0	0	0	1564	1609	56	5	57	5	BTN3A3	6	26443857	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	15647490	26443857	144671210	78	17347										
OR14J1	442191	broad.mit.edu	37	chr6	29274561	29274561	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgcattggtatttctggtgaCatacctgctggccttgacag	11	9	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:29274561C>T	uc011dln.1	+	1	95	c.95C>T	c.(94-96)ACA>ATA	p.T32I		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCTGGTGACATACCTGCTG	0.438													0	0	0	0.020292	0	12	71										T	29274561	C	T	29274561	3	4	60	1	0	0	0	0	1	0	0	0	10948	478	17	2	97	2	OR14J1	6	29274561	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2830704	29274561	141840506	79	17348										
RDBP	7936	broad.mit.edu	37	chr6	31922614	31922614	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atcaccagcccctgggccctCtgcctcttctccatctggtc	7	19	5	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:31922614C>G	uc003nyk.2	-	7	664	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	RDBP_uc011dot.1_Intron|RDBP_uc003nyl.1_Missense_Mutation_p.E94Q|RDBP_uc003nym.1_Missense_Mutation_p.E149Q	NM_002904	NP_002895	P18615	NELFE_HUMAN	RD RNA-binding protein	154					positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	mitochondrion|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						CCTGGGCCCTCTGCCTCTTCT	0.577													0	0	0	0.041601	0	22	133										G	31922614	C	G	31922614	3	3	60	1	0	0	0	0	1	0	0	0	13188	922	32	1	702	1	RDBP	6	31922614	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2648053	31922614	139192453	80	17349										
TNXB	7148	broad.mit.edu	37	chr6	32015617	32015617	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aggccctggactgtgacctcCcgctggttggctgccaccgg	14	15	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:32015617C>T	uc003nzl.2	-	30	10414	c.10212G>A	c.(10210-10212)CGG>CGA	p.R3404R	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3451	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTGTGACCTCCCGCTGGTTGG	0.602													0	0	0	0.009096	0	4	15										T	32015617	C	T	32015617	2	4	60	1	0	0	0	0	0	0	0	1	16343	610	22	2		2	TNXB	6	32015617	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	93003	32015617	139099450	81	17350										
TAPBP	6892	broad.mit.edu	37	chr6	33271748	33271748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtaccttctttgaatccttgCaggtggacaggtagacagct	11	9	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:33271748C>T	uc003odx.1	-	7	1490	c.1319G>A	c.(1318-1320)TGC>TAC	p.C440Y	TAPBP_uc010jus.1_Missense_Mutation_p.C458Y|TAPBP_uc003ody.2_3'UTR|TAPBP_uc003odz.2_Missense_Mutation_p.C440Y|TAPBP_uc010jut.1_Missense_Mutation_p.C353Y	NM_003190	NP_003181	O15533	TPSN_HUMAN	tapasin isoform 1 precursor	440	Cytoplasmic (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			ovary(1)	1						TGAATCCTTGCAGGTGGACAG	0.483													0	0	0	0.028581	0	14	83										T	33271748	C	T	33271748	3	4	60	1	0	0	0	0	1	0	0	0	15549	710	25	2	215	2	TAPBP	6	33271748	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1256131	33271748	137843319	82	17351										
FANCE	2178	broad.mit.edu	37	chr6	35426107	35426107	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtgcccagctgcagctccctCagctctcagacctcggtctc	9	18	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:35426107C>T	uc003oko.1	+	5	1188	c.1003C>T	c.(1003-1005)CAG>TAG	p.Q335*	FANCE_uc010jvw.1_Nonsense_Mutation_p.Q328*	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	335	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						GCAGCTCCCTCAGCTCTCAGA	0.602			N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.048971	0	43	146										T	35426107	C	T	35426107	4	4	60	1	0	0	0	0	0	1	0	0	5666	827	29	1	1021	1	FANCE	6	35426107	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2154359	35426107	135688960	83	17352										
SLC26A8	116369	broad.mit.edu	37	chr6	35923092	35923092	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtcctggtgagctgtttcttGatgagttattaggaagccaa	12	6	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:35923092G>C	uc003olm.2	-	17	2180	c.2069C>G	c.(2068-2070)TCA>TGA	p.S690*	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Nonsense_Mutation_p.S272*|SLC26A8_uc003oln.2_Nonsense_Mutation_p.S690*|SLC26A8_uc003oll.2_Nonsense_Mutation_p.S585*	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	690	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						GCTGTTTCTTGATGAGTTATT	0.512													0	0	0	0.009096	0	4	60										C	35923092	G	C	35923092	4	2	60	1	0	0	0	0	0	1	0	0	14523	1294	45	1	859	1	SLC26A8	6	35923092	Nonsense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	496985	35923092	135191975	84	17353										
MAPK13	5603	broad.mit.edu	37	chr6	36098379	36098379	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gatgagcctcatccggaaaaAgggcttctacaagcaggacg	12	10	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:36098379A>G	uc003ols.2	+	1	118	c.20A>G	c.(19-21)AAG>AGG	p.K7R	MAPK13_uc003olt.2_RNA	NM_002754	NP_002745	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	7					cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)	3						ATCCGGAAAAAGGGCTTCTAC	0.617													0	0	0	0.004672	0	2	10										G	36098379	A	G	36098379	3	3	60	1	0	0	0	0	1	0	0	0	9275	72	3	5	22	5	MAPK13	6	36098379	Missense_Mutation	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	175287	36098379	135016688	85	17354										
NCR2	9436	broad.mit.edu	37	chr6	41304071	41304071	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtcaccatgactgatctgaGagaggaagactcaggacatt	11	8	3	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:41304071G>C	uc003oqh.2	+	2	386	c.299G>C	c.(298-300)AGA>ACA	p.R100T	NCR2_uc003oqi.2_Missense_Mutation_p.R100T|NCR2_uc003oqj.2_Missense_Mutation_p.R100T	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	100	Extracellular (Potential).|Ig-like.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					ACTGATCTGAGAGAGGAAGAC	0.517													0	0	0	0.014758	0	3	72										C	41304071	G	C	41304071	3	2	60	1	0	0	0	0	1	0	0	0	10238	942	33	1	305	1	NCR2	6	41304071	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	5205692	41304071	129810996	86	17355										
FRS3	10817	broad.mit.edu	37	chr6	41738604	41738604	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtagttaagctgccttgggGgctcgggccccggccggcgg	18	12	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:41738604G>T	uc003orc.1	-	7	1476	c.1232C>A	c.(1231-1233)CCC>CAC	p.P411H		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	411					fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGCCTTGGGGGCTCGGGCCC	0.687													1	0	7.48243e-07	0.058154	8.15997e-07	9	30										T	41738604	G	T	41738604	3	4	60	1	0	0	0	0	1	0	0	0	6062	1232	43	4	250	4	FRS3	6	41738604	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	434533	41738604	129376463	87	17356										
CUL9	23113	broad.mit.edu	37	chr6	43181255	43181255	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggcactcgtgcccctcacctCagggaatggccctttgaccc	10	17	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:43181255C>T	uc003ouk.2	+	28	5513	c.5438C>T	c.(5437-5439)TCA>TTA	p.S1813L	CUL9_uc003oul.2_Missense_Mutation_p.S1813L|CUL9_uc010jyk.2_Missense_Mutation_p.S965L|CUL9_uc003oun.2_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1813					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCCCTCACCTCAGGGAATGGC	0.632													0	0	0	0.09319	0	12	65										T	43181255	C	T	43181255	3	4	60	1	0	0	0	0	1	0	0	0	4061	838	29	1	5544	1	CUL9	6	43181255	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1442651	43181255	127933812	88	17357										
CYP39A1	51302	broad.mit.edu	37	chr6	46607286	46607286	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcctaaattctccagttgttCatgtaattcttcagtcagtt	6	9	5	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:46607286C>A	uc003oyf.1	-	3	637	c.433G>T	c.(433-435)GAA>TAA	p.E145*	CYP39A1_uc011dwa.1_Nonsense_Mutation_p.E125*|CYP39A1_uc010jzd.1_Intron	NM_016593	NP_057677	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A,	145					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1						TCCAGTTGTTCATGTAATTCT	0.363													1	0	2.17888e-05	0.058154	2.3303e-05	9	82										A	46607286	C	A	46607286	4	1	60	1	0	0	0	0	0	1	0	0	4177	835	29	3	1016	3	CYP39A1	6	46607286	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	3426031	46607286	124507781	89	17358			1	71		2	2	13	C		8.954054e-05
CYP39A1	51302	broad.mit.edu	37	chr6	46607298	46607298	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cagttgttcatgtaattcttCagtcagttgcccagtaaact	7	9	4	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:46607298C>T	uc003oyf.1	-	3	625	c.421G>A	c.(421-423)GAA>AAA	p.E141K	CYP39A1_uc011dwa.1_Missense_Mutation_p.E121K|CYP39A1_uc010jzd.1_Intron	NM_016593	NP_057677	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A,	141					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1						TGTAATTCTTCAGTCAGTTGC	0.378													0	0	0	0.038147	0	7	75										T	46607298	C	T	46607298	3	4	60	1	0	0	0	0	1	0	0	0	4177	835	29	1	1028	1	CYP39A1	6	46607298	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	12	46607298	124507769	90	17359			1	71		2	2	13	C		8.954054e-05
SIM1	6492	broad.mit.edu	37	chr6	100911253	100911253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccagctgcgaggtgatagccGagggcaaaggcagtaattta	14	8	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:100911253G>A	uc003pqj.3	-	1	299	c.92C>T	c.(91-93)TCG>TTG	p.S31L	SIM1_uc010kcu.2_Missense_Mutation_p.S31L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	31	Helix-loop-helix motif.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGTGATAGCCGAGGGCAAAGG	0.458													0	0	0	0.0333	0	16	80										A	100911253	G	A	100911253	3	1	60	1	0	0	0	0	1	0	0	0	14323	1059	37	1	2252	1	SIM1	6	100911253	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	54303955	100911253	70203814	91	17360										
NT5DC1	221294	broad.mit.edu	37	chr6	116436852	116436852	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttaaaattttgttcttttttAggaaagtattacttttacga	5	3	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:116436852A>G	uc003pwj.2	+	5	460	c.365_splice	c.e5-2	p.G122_splice	NT5DC1_uc003pwk.2_Splice_Site_p.G122_splice|NT5DC1_uc003pwl.2_Splice_Site_p.G72_splice	NM_152729	NP_689942	Q5TFE4	NT5D1_HUMAN	5'-nucleotidase, cytosolic II-like 1 protein								hydrolase activity|metal ion binding				0		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)		GTTCTTTTTTAGGAAAGTATT	0.368													0	0	0	0.047766	0	8	20										G	116436852	A	G	116436852	5	3	60	1	0	0	0	0	0	0	1	0	10690	434	15	5	381	5	NT5DC1	6	116436852	Splice_Site	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	15525599	116436852	54678215	92	17361										
IL20RA	53832	broad.mit.edu	37	chr6	137330458	137330458	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tccatttcaggcttaccgttCtgtttgatttagtattcaac	6	9	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:137330458C>T	uc003qhj.2	-	4	1008	c.575G>A	c.(574-576)AGA>AAA	p.R192K	IL20RA_uc011edl.1_Missense_Mutation_p.R143K|IL20RA_uc003qhk.2_Missense_Mutation_p.R81K|IL20RA_uc010kgy.1_RNA|IL20RA_uc003qhi.2_5'Flank	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	192	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		GCTTACCGTTCTGTTTGATTT	0.403													0	0	0	0.024245	0	14	91										T	137330458	C	T	137330458	3	4	60	1	0	0	0	0	1	0	0	0	7668	913	32	1	1102	1	IL20RA	6	137330458	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	20893606	137330458	33784609	93	17362										
TXLNB	167838	broad.mit.edu	37	chr6	139583802	139583802	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acagagcttcatatttcgctCactctgctgctcgatctggc	8	13	4	1	rs140293549		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:139583802C>G	uc011eds.1	-	5	961	c.796G>C	c.(796-798)GAG>CAG	p.E266Q		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	266	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		ATATTTCGCTCACTCTGCTGC	0.502													0	0	0	0.055883	0	17	57										G	139583802	C	G	139583802	3	3	60	1	0	0	0	0	1	0	0	0	16785	835	29	1	1282	1	TXLNB	6	139583802	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2253344	139583802	31531265	94	17363										
SF3B5	83443	broad.mit.edu	37	chr6	144416498	144416498	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agtagttgagaaggtcgaagTggcccatgtaggagcagtac	15	6	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:144416498T>C	uc003qkr.1	-	1	257	c.137A>G	c.(136-138)CAC>CGC	p.H46R		NM_031287	NP_112577	Q9BWJ5	SF3B5_HUMAN	SF3b10	46					nuclear mRNA splicing, via spliceosome	nucleoplasm|U12-type spliceosomal complex					0				OV - Ovarian serous cystadenocarcinoma(155;1.68e-06)|GBM - Glioblastoma multiforme(68;0.0638)		AAGGTCGAAGTGGCCCATGTA	0.572													0	0	0	0.062417	0	20	68										C	144416498	T	C	144416498	3	2	60	1	0	0	0	0	1	0	0	0	14154	1696	59	5	127	5	SF3B5	6	144416498	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	4832696	144416498	26698569	95	17364										
FNDC1	84624	broad.mit.edu	37	chr6	159654497	159654497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctgctcgtccgcccgcagcaCggtcacagcagcatcccagt	10	18	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr6:159654497C>T	uc010kjv.2	+	11	3153	c.2953C>T	c.(2953-2955)CGG>TGG	p.R985W	FNDC1_uc010kjw.1_Missense_Mutation_p.R870W	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	985						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCCGCAGCACGGTCACAGCA	0.677													0	0	0	0.004672	0	3	14										T	159654497	C	T	159654497	3	4	60	1	0	0	0	0	1	0	0	0	5968	527	19	2	2995	2	FNDC1	6	159654497	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	15237999	159654497	11460570	96	17365										
SNX13	23161	broad.mit.edu	37	chr7	17879515	17879515	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tggtttgatgttttccatctCtctgacgacttaataaaact	6	8	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr7:17879515C>T	uc003stw.1	-	13	1487	c.1274G>A	c.(1273-1275)AGA>AAA	p.R425K	SNX13_uc003stv.2_Missense_Mutation_p.R425K|SNX13_uc010kuc.2_Missense_Mutation_p.R222K			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	425	RGS.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					TTTTCCATCTCTCTGACGACT	0.413													0	0	0	0.021553	0	6	34										T	17879515	C	T	17879515	3	4	60	1	0	0	0	0	1	0	0	0	14884	913	32	1	1655	1	SNX13	7	17879515	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		17879515	141259148	97	17366										
ELMO1	9844	broad.mit.edu	37	chr7	37252967	37252967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgggggtccattttggtcatCatcctgtcttccaggaggtt	12	9	3	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr7:37252967C>T	uc003tfk.1	-	12	1234	c.927G>A	c.(925-927)ATG>ATA	p.M309I	ELMO1_uc011kbc.1_Missense_Mutation_p.M213I|ELMO1_uc010kxg.1_Missense_Mutation_p.M309I	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	309					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						TTTTGGTCATCATCCTGTCTT	0.498													0	0	0	0.080935	0	11	71										T	37252967	C	T	37252967	3	4	60	1	0	0	0	0	1	0	0	0	5065	826	29	1	1300	1	ELMO1	7	37252967	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	19373452	37252967	121885696	98	17367										
SLC26A4	5172	broad.mit.edu	37	chr7	107329646	107329646	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acaccatcgatgggaaccagGtatgggtgcccttttgctga	12	10	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr7:107329646G>A	uc003vep.2	+	9	1373	c.1149_splice	c.e9+1	p.Q383_splice	SLC26A4_uc011kmb.1_5'Flank|SLC26A4_uc011kmc.1_5'Flank	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin						regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						TGGGAACCAGGTATGGGTGCC	0.433									Pendred_syndrome				0	0	0	0.049695	0	18	105										A	107329646	G	A	107329646	5	1	60	1	0	0	0	0	0	0	1	0	14519	1275	44	2	1180	2	SLC26A4	7	107329646	Splice_Site	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	70076679	107329646	51809017	99	17368										
CADPS2	93664	broad.mit.edu	37	chr7	122130270	122130270	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tattctgtcctgttcatcatCactggcaaagattacagtat	6	9	4	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr7:122130270C>A	uc010lkp.2	-	11	1880	c.1717G>T	c.(1717-1719)GAT>TAT	p.D573Y	CADPS2_uc003vkg.3_Missense_Mutation_p.D273Y|CADPS2_uc010lkq.2_Missense_Mutation_p.D573Y	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	573	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TGTTCATCATCACTGGCAAAG	0.388													1	0	1.26484e-09	0.038147	1.40708e-09	6	133										A	122130270	C	A	122130270	3	1	60	1	0	0	0	0	1	0	0	0	2571	826	29	3	2297	3	CADPS2	7	122130270	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	14800624	122130270	37008393	100	17369										
CSMD3	114788	broad.mit.edu	37	chr8	113353795	113353795	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gggtggtgctgaataaggaaGatggtatttgaggaccacta	15	4	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr8:113353795G>C	uc003ynu.2	-	42	6722	c.6563C>G	c.(6562-6564)TCT>TGT	p.S2188C	CSMD3_uc003yns.2_Missense_Mutation_p.S1390C|CSMD3_uc003ynt.2_Missense_Mutation_p.S2148C|CSMD3_uc011lhx.1_Missense_Mutation_p.S2084C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2188	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAATAAGGAAGATGGTATTTG	0.368										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.076483	0	20	87										C	113353795	G	C	113353795	3	2	60	1	0	0	0	0	1	0	0	0	3946	942	33	1	4680	1	CSMD3	8	113353795	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		113353795	33010227	101	17370										
CSMD3	114788	broad.mit.edu	37	chr8	113353910	113353910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaaatttacaaactggagatGtacacctgaagaagaaaaca	7	6	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr8:113353910G>A	uc003ynu.2	-	42	6607	c.6448C>T	c.(6448-6450)CAT>TAT	p.H2150Y	CSMD3_uc003yns.2_Missense_Mutation_p.H1352Y|CSMD3_uc003ynt.2_Missense_Mutation_p.H2110Y|CSMD3_uc011lhx.1_Missense_Mutation_p.H2046Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2150	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACTGGAGATGTACACCTGAA	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.014758	0	5	19										A	113353910	G	A	113353910	3	1	60	1	0	0	0	0	1	0	0	0	3946	1377	48	2	4795	2	CSMD3	8	113353910	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	115	113353910	33010112	102	17371										
ATAD2	29028	broad.mit.edu	37	chr8	124383930	124383930	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttagttataagtttgtcaaaCagcatggactggtttacacc	8	7	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr8:124383930C>A	uc003yqh.3	-	4	624	c.516G>T	c.(514-516)CTG>CTT	p.L172L	ATAD2_uc011lii.1_5'UTR|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Silent_p.L172L	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GTTTGTCAAACAGCATGGACT	0.363													1	0	1.76689e-08	0.058154	1.94992e-08	7	48										A	124383930	C	A	124383930	2	1	60	1	0	0	0	0	0	0	0	1	1071	465	17	4		4	ATAD2	8	124383930	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	11030020	124383930	21980092	103	17372										
PHF20L1	51105	broad.mit.edu	37	chr8	133851656	133851656	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gaggtggagtgcaaaatatcGttatgataaggagtggttga	15	2	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr8:133851656G>A	uc003ytt.2	+	18	2541	c.2216G>A	c.(2215-2217)CGT>CAT	p.R739H	PHF20L1_uc011lja.1_Missense_Mutation_p.R713H	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	739							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GCAAAATATCGTTATGATAAG	0.368													0	0	0	0.076483	0	20	113										A	133851656	G	A	133851656	3	1	60	1	0	0	0	0	1	0	0	0	11832	1145	40	2	2378	2	PHF20L1	8	133851656	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	9467726	133851656	12512366	104	17373										
FAM135B	51059	broad.mit.edu	37	chr8	139163874	139163874	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctttgctggcctgttgagttCctgttgatggcatcagcagc	12	10	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr8:139163874C>A	uc003yuy.2	-	13	3015	c.2844G>T	c.(2842-2844)AGG>AGT	p.R948S	FAM135B_uc003yux.2_Missense_Mutation_p.R849S|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.R510S|FAM135B_uc003yvb.2_Missense_Mutation_p.R510S	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	948										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGTTGAGTTCCTGTTGATGG	0.488										HNSCC(54;0.14)			1	0	1.75199e-13	0.034045	2.01369e-13	29	114										A	139163874	C	A	139163874	3	1	60	1	0	0	0	0	1	0	0	0	5449	854	30	3	1408	3	FAM135B	8	139163874	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	5312218	139163874	7200148	105	17374										
FAM83H	286077	broad.mit.edu	37	chr8	144811408	144811408	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcatctcatccagcaggatgTagactgggacccgacgggcc	12	13	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr8:144811408T>C	uc003yzk.2	-	3	602	c.533A>G	c.(532-534)TAC>TGC	p.Y178C	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	178					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CAGCAGGATGTAGACTGGGAC	0.632													0	0	0	0.099896	0	24	99										C	144811408	T	C	144811408	3	2	60	1	0	0	0	0	1	0	0	0	5640	1638	57	5	3018	5	FAM83H	8	144811408	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	5647534	144811408	1552614	106	17375										
SMARCA2	6595	broad.mit.edu	37	chr9	2088542	2088542	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctatattgatcatcaggcgtCtacataaggtgttaagacca	8	8	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:2088542C>A	uc003zhc.2	+	19	2911	c.2812C>A	c.(2812-2814)CTA>ATA	p.L938I	SMARCA2_uc003zhd.2_Missense_Mutation_p.L938I|SMARCA2_uc010mha.2_Missense_Mutation_p.L871I	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	938					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CATCAGGCGTCTACATAAGGT	0.343													1	0	9.70103e-10	0.069234	1.08354e-09	9	78										A	2088542	C	A	2088542	3	1	60	1	0	0	0	0	1	0	0	0	14769	912	32	3	2882	3	SMARCA2	9	2088542	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		2088542	139124889	107	17376										
CNTLN	54875	broad.mit.edu	37	chr9	17502622	17502622	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaagaaactagttgaaggatAtttcacaattatgaaagata	7	3	1	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:17502622A>T	uc003zmy.2	+	26	4219	c.4193A>T	c.(4192-4194)TAT>TTT	p.Y1398F	CNTLN_uc010mio.2_3'UTR	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	Error:Variant_position_missing_in_Q9NXG0_after_alignment						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		GTTGAAGGATATTTCACAATT	0.279													0	0	0	0.009096	0	4	14										T	17502622	A	T	17502622	3	4	60	1	0	0	0	0	1	0	0	0	3639	449	16	5	4325	5	CNTLN	9	17502622	Missense_Mutation	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	15414080	17502622	123710809	108	17377										
LRRC19	64922	broad.mit.edu	37	chr9	26995683	26995683	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atttccagtaaaaccatcttCataggtttctgcttcatgct	5	10	4	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:26995683C>T	uc003zqh.2	-	5	1060	c.949G>A	c.(949-951)GAA>AAA	p.E317K	IFT74_uc010mja.2_Intron|IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_022901	NP_075052	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19 precursor	317	Cytoplasmic (Potential).					integral to membrane					0		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)		AAACCATCTTCATAGGTTTCT	0.343													0	0	0	0.058154	0	9	67										T	26995683	C	T	26995683	3	4	60	1	0	0	0	0	1	0	0	0	8975	835	29	1	167	1	LRRC19	9	26995683	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	9493061	26995683	114217748	109	17378										
VPS13A	23230	broad.mit.edu	37	chr9	79959136	79959136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agtcgaaaggagtgaagatcCtcccaaaaggatatatttta	9	6	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:79959136C>T	uc004akr.2	+	51	7354	c.7094C>T	c.(7093-7095)CCT>CTT	p.P2365L	VPS13A_uc004akp.3_Missense_Mutation_p.P2365L|VPS13A_uc004akq.3_Missense_Mutation_p.P2365L|VPS13A_uc004aks.2_Missense_Mutation_p.P2326L	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2365					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						AGTGAAGATCCTCCCAAAAGG	0.303													0	0	0	0.038395	0	15	57										T	79959136	C	T	79959136	3	4	60	1	0	0	0	0	1	0	0	0	17186	681	24	2	7296	2	VPS13A	9	79959136	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	52963453	79959136	61254295	110	17379										
FKBP15	23307	broad.mit.edu	37	chr9	115950730	115950730	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agagagggctggacggacggAgtcaccacaggctgcccacc	15	13	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:115950730A>G	uc004bgs.2	-	13	1333	c.1215T>C	c.(1213-1215)ACT>ACC	p.T405T	FKBP15_uc010muu.1_Silent_p.T469T|FKBP15_uc011lxc.1_5'Flank|FKBP15_uc011lxd.1_Silent_p.T337T|FKBP15_uc010mut.1_Silent_p.T273T|FKBP15_uc004bgt.2_Silent_p.T405T	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	405					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						GGACGGACGGAGTCACCACAG	0.567													0	0	0	0.069234	0	9	53										G	115950730	A	G	115950730	2	3	60	1	0	0	0	0	0	0	0	1	5905	291	11	5		5	FKBP15	9	115950730	Silent	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	35991594	115950730	25262701	111	17380										
SURF1	6834	broad.mit.edu	37	chr9	136220672	136220672	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gttgaggaggagatgaggccGccctcccgggcctcccggac	16	14	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:136220672G>A	uc004cdh.1	-	5	479	c.447C>T	c.(445-447)GGC>GGT	p.G149G	SURF1_uc004cdg.1_Silent_p.G40G|SURF2_uc004cdi.2_5'Flank	NM_003172	NP_003163	Q15526	SURF1_HUMAN	surfeit 1	149					aerobic respiration|respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			breast(2)	2				OV - Ovarian serous cystadenocarcinoma(145;5.06e-07)|Epithelial(140;4.25e-06)|all cancers(34;3.93e-05)		AGATGAGGCCGCCCTCCCGGG	0.612													0	0	0	0.009096	0	4	159										A	136220672	G	A	136220672	2	1	60	1	0	0	0	0	0	0	0	1	15400	1074	38	2		2	SURF1	9	136220672	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	20269942	136220672	4992759	112	17381										
RXRA	6256	broad.mit.edu	37	chr9	137293529	137293529	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctccccgacggggcgaggctCcatggctgccccctcgctgc	13	19	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr9:137293529C>G	uc004cfb.2	+	2	242	c.80C>G	c.(79-81)TCC>TGC	p.S27C	RXRA_uc004cfa.1_Silent_p.L77L	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	27	Modulating (By similarity).			S->A: Increase in RARA-mediated transcriptional activity.|S->A: Abolishes phosphorylation. No change in increase of RARA-mediated transcriptional activity.	cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GGGCGAGGCTCCATGGCTGCC	0.662													0	0	0	0.0918	0	25	54										G	137293529	C	G	137293529	3	3	60	1	0	0	0	0	1	0	0	0	13763	855	30	1	86	1	RXRA	9	137293529	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1072857	137293529	3919902	113	17382										
DIP2C	22982	broad.mit.edu	37	chr10	468809	468809	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cgccagcctgtgggcagcccCgctgcccccgctctgcgtag	13	19	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:468809C>T	uc001ifp.2	-	5	649	c.559G>A	c.(559-561)GGG>AGG	p.G187R	DIP2C_uc009xhk.1_Silent_p.A188A	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	187						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TGGGCAGCCCCGCTGCCCCCG	0.617													0	0	0	0.105934	0	10	61										T	468809	C	T	468809	3	4	60	1	0	0	0	0	1	0	0	0	4529	652	23	2	4243	2	DIP2C	10	468809	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		468809	135065938	114	17383										
LARP4B	23185	broad.mit.edu	37	chr10	888915	888915	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tccacatcagtgctgagcttCttgatgtggtcgaggttagc	12	9	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:888915C>A	uc001ifs.1	-	6	644	c.603G>T	c.(601-603)AAG>AAT	p.K201N		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	201	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						TGCTGAGCTTCTTGATGTGGT	0.388													1	0	3.59834e-05	0.021553	3.81892e-05	5	47										A	888915	C	A	888915	3	1	60	1	0	0	0	0	1	0	0	0	8631	912	32	3	1661	3	LARP4B	10	888915	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	420106	888915	134645832	115	17384										
CALML3	810	broad.mit.edu	37	chr10	5567418	5567418	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgagtgacgaggaggtggacGagatgatccgggccgcggac	19	8	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:5567418G>A	uc001iie.1	+	1	495	c.370G>A	c.(370-372)GAG>AAG	p.E124K	uc001iid.1_5'Flank	NM_005185	NP_005176	P27482	CALL3_HUMAN	calmodulin-like 3	124	EF-hand 4.						calcium ion binding				0						GGAGGTGGACGAGATGATCCG	0.657													0	0	0	0.09319	0	10	32										A	5567418	G	A	5567418	3	1	60	1	0	0	0	0	1	0	0	0	2587	1059	37	1	372	1	CALML3	10	5567418	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	4678503	5567418	129967329	116	17385										
C10orf18	54906	broad.mit.edu	37	chr10	5790413	5790413	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atgtaagaccaataaatgcaGagccagtgtttcaagcacag	9	8	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:5790413G>A	uc001iij.2	+	15	5654	c.5029G>A	c.(5029-5031)GAG>AAG	p.E1677K	C10orf18_uc001iik.2_Missense_Mutation_p.E521K	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1677										ovary(1)|central_nervous_system(1)	2						AATAAATGCAGAGCCAGTGTT	0.453													0	0	0	0.105934	0	9	51										A	5790413	G	A	5790413	3	1	60	1	0	0	0	0	1	0	0	0	1596	943	33	1	5075	1	C10orf18	10	5790413	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	222995	5790413	129744334	117	17386										
PCDH15	65217	broad.mit.edu	37	chr10	55587219	55587219	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcggcggcggcggcgggggcGctgccactggtgcaggagcc	22	13	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:55587219G>A	uc001jju.1	-	32	4696	c.4301C>T	c.(4300-4302)GCG>GTG	p.A1434V	PCDH15_uc010qhq.1_Missense_Mutation_p.A1439V|PCDH15_uc010qhr.1_Missense_Mutation_p.A1434V|PCDH15_uc010qhs.1_Missense_Mutation_p.A1446V|PCDH15_uc010qht.1_Missense_Mutation_p.A1441V|PCDH15_uc010qhu.1_Missense_Mutation_p.A1434V|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.A1431V|PCDH15_uc010qhw.1_Missense_Mutation_p.A1394V|PCDH15_uc010qhx.1_Missense_Mutation_p.A1363V|PCDH15_uc010qhy.1_Missense_Mutation_p.A1439V|PCDH15_uc010qhz.1_Missense_Mutation_p.A1434V|PCDH15_uc010qia.1_Missense_Mutation_p.A1412V|PCDH15_uc010qib.1_Missense_Mutation_p.A1409V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1434	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				cggcgggggcgCTGCCACTGG	0.443										HNSCC(58;0.16)			0	0	0	0.09319	0	10	59										A	55587219	G	A	55587219	3	1	60	1	0	0	0	0	1	0	0	0	11511	1087	38	2	3193	2	PCDH15	10	55587219	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	49796806	55587219	79947528	118	17387										
JMJD1C	221037	broad.mit.edu	37	chr10	64950860	64950860	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttggttttcaagggtaagttCtttgttttctgaaatagaaa	9	3	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:64950860C>T	uc001jmn.2	-	17	6385	c.6085G>A	c.(6085-6087)GAA>AAA	p.E2029K	JMJD1C_uc001jml.2_Missense_Mutation_p.E1792K|JMJD1C_uc001jmm.2_Missense_Mutation_p.E1741K|JMJD1C_uc010qiq.1_Missense_Mutation_p.E1847K|JMJD1C_uc009xpi.2_Missense_Mutation_p.E1847K|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_5'UTR	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2029					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGGGTAAGTTCTTTGTTTTCT	0.224													0	0	0	0.02938	0	6	30										T	64950860	C	T	64950860	3	4	60	1	0	0	0	0	1	0	0	0	7950	922	32	1	1577	1	JMJD1C	10	64950860	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	9363641	64950860	70583887	119	17388										
MAT1A	4143	broad.mit.edu	37	chr10	82043687	82043687	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctcacccttggctgagtcatCgtagccgatgtgcttgatgg	12	11	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:82043687C>T	uc001kbw.2	-	3	532	c.277G>A	c.(277-279)GAT>AAT	p.D93N		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	93					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GCTGAGTCATCGTAGCCGATG	0.587													0	0	0	0.055883	0	15	75										T	82043687	C	T	82043687	3	4	60	1	0	0	0	0	1	0	0	0	9329	884	31	1	938	1	MAT1A	10	82043687	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	17092827	82043687	53491060	120	17389										
WAPAL	23063	broad.mit.edu	37	chr10	88206121	88206121	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cttgccactctccactcttaTcatgctgagtggtgggagca	10	12	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:88206121T>C	uc001kdo.2	-	16	3642	c.3200A>G	c.(3199-3201)GAT>GGT	p.D1067G	WAPAL_uc009xsv.2_Missense_Mutation_p.D326G|WAPAL_uc001kdn.2_Missense_Mutation_p.D1104G|WAPAL_uc009xsw.2_Missense_Mutation_p.D1061G	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	1067	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TCCACTCTTATCATGCTGAGT	0.438													0	0	0	0.069234	0	9	90										C	88206121	T	C	88206121	3	2	60	1	0	0	0	0	1	0	0	0	17245	1435	50	5	388	5	WAPAL	10	88206121	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	6162434	88206121	47328626	121	17390										
CEP55	55165	broad.mit.edu	37	chr10	95275294	95275294	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	attcactcccacagcagacaAaaaagcctgaatcagaaggt	7	11	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:95275294A>G	uc009xug.2	+	5	843	c.661A>G	c.(661-663)AAA>GAA	p.K221E	CEP55_uc001kiq.3_Missense_Mutation_p.K221E	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	221	Interaction with TSG101.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				ACAGCAGACAAAAAAGCCTGA	0.378													0	0	0	0.043863	0	16	61										G	95275294	A	G	95275294	3	3	60	1	0	0	0	0	1	0	0	0	3255	15	1	5	675	5	CEP55	10	95275294	Missense_Mutation	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	7069173	95275294	40259453	122	17391										
PDZD7	79955	broad.mit.edu	37	chr10	102789913	102789913	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcgggaggagagggagctcaGagagccggagctcaggtctc	18	9	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:102789913G>A	uc001kso.1	-	2	279	c.64C>T	c.(64-66)CTG>TTG	p.L22L	PDZD7_uc001ksn.2_Silent_p.L22L|SFXN3_uc001ksp.2_5'Flank|SFXN3_uc001ksq.2_5'Flank|SFXN3_uc010qpx.1_5'Flank	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	22						cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		AGGGAGCTCAGAGAGCCGGAG	0.662													0	0	0	0.009096	0	4	24										A	102789913	G	A	102789913	2	1	60	1	0	0	0	0	0	0	0	1	11704	933	33	1		1	PDZD7	10	102789913	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	7514619	102789913	32744834	123	17392										
CCDC147	159686	broad.mit.edu	37	chr10	106214254	106214254	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcctggttttactgggggcgGatttcctctcaggtcaacca	11	11	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:106214254G>T	uc001kyh.2	+	18	2719	c.2585G>T	c.(2584-2586)GGA>GTA	p.G862V		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	862										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ACTGGGGGCGGATTTCCTCTC	0.463													1	0	1.56452e-12	0.043863	1.78343e-12	19	102										T	106214254	G	T	106214254	3	4	60	1	0	0	0	0	1	0	0	0	2781	1174	41	3	2655	3	CCDC147	10	106214254	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3424341	106214254	29320493	124	17393										
PNLIP	5406	broad.mit.edu	37	chr10	118321149	118321149	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gagacaaatgttggaaaacaGtaagtaatgaaaatcccagg	10	5	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr10:118321149G>A	uc001lcm.2	+	12	1377	c.1334_splice	c.e12+1	p.Q445_splice		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TTGGAAAACAGTAAGTAATGA	0.363													0	0	0	0.083992	0	19	70										A	118321149	G	A	118321149	5	1	60	1	0	0	0	0	0	0	1	0	12149	1043	36	2	1377	2	PNLIP	10	118321149	Splice_Site	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	12106895	118321149	17213598	125	17394										
SIGIRR	59307	broad.mit.edu	37	chr11	408082	408082	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acccccatcaccagctctctGaagagtgaaggaggagaagc	11	12	2	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:408082G>A	uc001lpd.2	-	4	661	c.331C>T	c.(331-333)CAG>TAG	p.Q111*	SIGIRR_uc001lpf.2_Nonsense_Mutation_p.Q111*|SIGIRR_uc001lpe.1_Nonsense_Mutation_p.Q111*|SIGIRR_uc001lpg.2_Nonsense_Mutation_p.Q111*	NM_001135054	NP_001128526	Q6IA17	SIGIR_HUMAN	single Ig IL-1R-related molecule	111	Extracellular (Potential).				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity				0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCAGCTCTCTGAAGAGTGAAG	0.592													0	0	0	0.055883	0	18	69										A	408082	G	A	408082	4	1	60	1	0	0	0	0	0	1	0	0	14304	1299	45	1	929	1	SIGIRR	11	408082	Nonsense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		408082	134598434	126	17395										
EPS8L2	64787	broad.mit.edu	37	chr11	720214	720214	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcgctgcggctgctggacatCgagtcacaggtggggcccag	16	12	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:720214C>T	uc001lqt.2	+	5	565	c.318C>T	c.(316-318)ATC>ATT	p.I106I	EPS8L2_uc010qwj.1_Silent_p.I106I|EPS8L2_uc001lqu.2_Silent_p.I106I|EPS8L2_uc010qwk.1_Silent_p.I106I|EPS8L2_uc001lqv.2_Silent_p.I61I|EPS8L2_uc001lqw.2_5'Flank|EPS8L2_uc001lqx.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	106	PID.					cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCTGGACATCGAGTCACAGG	0.672													0	0	0	0.038147	0	6	31										T	720214	C	T	720214	2	4	60	1	0	0	0	0	0	0	0	1	5196	874	31	1		1	EPS8L2	11	720214	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	312132	720214	134286302	127	17396										
TRPM5	29850	broad.mit.edu	37	chr11	2428020	2428020	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccagggggtctggcaggtctCtctctgggaaagccaggtgg	17	10	3	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:2428020C>T	uc001lwm.3	-	21	3131	c.3122G>A	c.(3121-3123)AGA>AAA	p.R1041K	TRPM5_uc010qxl.1_Missense_Mutation_p.R1041K|TRPM5_uc009ydn.2_Missense_Mutation_p.R1043K	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1041	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGGCAGGTCTCTCTCTGGGAA	0.632													0	0	0	0.038147	0	6	44										T	2428020	C	T	2428020	3	4	60	1	0	0	0	0	1	0	0	0	16586	913	32	1	391	1	TRPM5	11	2428020	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1707806	2428020	132578496	128	17397										
ZNF214	7761	broad.mit.edu	37	chr11	7022459	7022459	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaccactcatgtagatttctCtaccatagtcttgagtggtt	7	9	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:7022459C>G	uc001mfa.2	-	3	758	c.455G>C	c.(454-456)AGA>ACA	p.R152T	ZNF214_uc010ray.1_Missense_Mutation_p.R152T|ZNF214_uc009yfh.1_Missense_Mutation_p.R152T	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GTAGATTTCTCTACCATAGTC	0.378													0	0	0	0.105934	0	12	74										G	7022459	C	G	7022459	3	3	60	1	0	0	0	0	1	0	0	0	17767	913	32	1	1369	1	ZNF214	11	7022459	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	4594439	7022459	127984057	129	17398										
AMBRA1	55626	broad.mit.edu	37	chr11	46567156	46567156	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atggggcagcgcactcaccgGacccgttccatctcactagc	10	16	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:46567156G>C	uc010rgu.1	-	5	909	c.549C>G	c.(547-549)GTC>GTG	p.V183V	AMBRA1_uc010rgt.1_5'Flank|AMBRA1_uc009ylc.1_Silent_p.V183V|AMBRA1_uc001ncu.1_Silent_p.V183V|AMBRA1_uc001ncv.2_Silent_p.V183V|AMBRA1_uc001ncw.2_Silent_p.V183V|AMBRA1_uc001ncx.2_Silent_p.V183V	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	183					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GCACTCACCGGACCCGTTCCA	0.547													0	0	0	0.028581	0	14	97										C	46567156	G	C	46567156	2	2	60	1	0	0	0	0	0	0	0	1	565	1161	41	1		1	AMBRA1	11	46567156	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	39544697	46567156	88439360	130	17399										
AMBRA1	55626	broad.mit.edu	37	chr11	46567257	46567257	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agtggcaatcagcaggagctGagccgtagggtggaaagcca	16	8	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:46567257G>A	uc010rgu.1	-	5	808	c.448C>T	c.(448-450)CAG>TAG	p.Q150*	AMBRA1_uc010rgt.1_5'Flank|AMBRA1_uc009ylc.1_Nonsense_Mutation_p.Q150*|AMBRA1_uc001ncu.1_Nonsense_Mutation_p.Q150*|AMBRA1_uc001ncv.2_Nonsense_Mutation_p.Q150*|AMBRA1_uc001ncw.2_Nonsense_Mutation_p.Q150*|AMBRA1_uc001ncx.2_Nonsense_Mutation_p.Q150*	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	150	WD 3.				autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AGCAGGAGCTGAGCCGTAGGG	0.527													0	0	0	0.024245	0	13	57										A	46567257	G	A	46567257	4	1	60	1	0	0	0	0	0	1	0	0	565	1299	45	1	3238	1	AMBRA1	11	46567257	Nonsense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	101	46567257	88439259	131	17400										
ZDHHC5	25921	broad.mit.edu	37	chr11	57457644	57457644	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttatgtcctctaccacataGaggaactctcaggggtccgc	9	12	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:57457644G>A	uc001nkx.1	+	5	1782	c.526G>A	c.(526-528)GAG>AAG	p.E176K	ZDHHC5_uc001nky.1_Missense_Mutation_p.E123K|ZDHHC5_uc001nkz.1_5'UTR	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	176						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						CTACCACATAGAGGAACTCTC	0.502													0	0	0	0.021553	0	6	75										A	57457644	G	A	57457644	3	1	60	1	0	0	0	0	1	0	0	0	17615	943	33	1	540	1	ZDHHC5	11	57457644	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	10890387	57457644	77548872	132	17401										
VWCE	220001	broad.mit.edu	37	chr11	61026231	61026231	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtggctgcaagggctgtggaGagtctagaggtggtgggaga	21	4	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:61026231G>C	uc001nra.2	-	20	3063	c.2784C>G	c.(2782-2784)CTC>CTG	p.L928L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	928						extracellular region	calcium ion binding			ovary(1)	1						GGGCTGTGGAGAGTCTAGAGG	0.642													0	0	0	0.0333	0	13	64										C	61026231	G	C	61026231	2	2	60	1	0	0	0	0	0	0	0	1	17242	929	33	1		1	VWCE	11	61026231	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3568587	61026231	73980285	133	17402										
RCOR2	283248	broad.mit.edu	37	chr11	63681907	63681907	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acctgtcttctttgtccttgCggccccccagccgccgggcc	10	19	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:63681907C>T	uc001nyc.2	-	6	975	c.587G>A	c.(586-588)CGC>CAC	p.R196H		NM_173587	NP_775858	Q8IZ40	RCOR2_HUMAN	REST corepressor 2	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)|skin(1)	2						TTTGTCCTTGCGGCCCCCCAG	0.602													0	0	0	0.014758	0	4	97										T	63681907	C	T	63681907	3	4	60	1	0	0	0	0	1	0	0	0	13183	768	27	2	1012	2	RCOR2	11	63681907	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2655676	63681907	71324609	134	17403										
ZFPL1	7542	broad.mit.edu	37	chr11	64855481	64855481	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctcttgggactgctgggcttCctggccctccttgccctcat	10	16	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:64855481C>T	uc001ocq.1	+	8	993	c.828C>T	c.(826-828)TTC>TTT	p.F276F		NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	276	Helical; (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGCTGGGCTTCCTGGCCCTCC	0.687													0	0	0	0.02938	0	7	101										T	64855481	C	T	64855481	2	4	60	1	0	0	0	0	0	0	0	1	17653	854	30	1		1	ZFPL1	11	64855481	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1173574	64855481	70151035	135	17404										
ANO1	55107	broad.mit.edu	37	chr11	70003070	70003070	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tagactgacaaagtgaagctGacatggagagatcggttccc	12	8	0	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:70003070G>A	uc001opj.2	+	16	1826	c.1521G>A	c.(1519-1521)CTG>CTA	p.L507L	ANO1_uc001opk.1_Silent_p.L449L|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Silent_p.L216L	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	507	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						AAGTGAAGCTGACATGGAGAG	0.502													0	0	0	0.014758	0	4	17										A	70003070	G	A	70003070	2	1	60	1	0	0	0	0	0	0	0	1	695	1277	45	1		1	ANO1	11	70003070	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	5147589	70003070	65003446	136	17405										
FAT3	120114	broad.mit.edu	37	chr11	92616261	92616261	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atcccgttccggaacctgcgCggcagtggggacggccgcaa	15	14	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:92616261C>T	uc001pdj.3	+	23	12656	c.12639C>T	c.(12637-12639)CGC>CGT	p.R4213R	FAT3_uc001pdi.3_Silent_p.R653R	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4213	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGAACCTGCGCGGCAGTGGGG	0.657										TCGA Ovarian(4;0.039)			0	0	0	0.0333	0	15	72										T	92616261	C	T	92616261	2	4	60	1	0	0	0	0	0	0	0	1	5691	755	27	2		2	FAT3	11	92616261	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	22613191	92616261	42390255	137	17406										
EXPH5	23086	broad.mit.edu	37	chr11	108384321	108384321	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgggactctgaggattccttCtgtcatcagaaatctgggaa	11	8	5	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:108384321C>T	uc001pkk.2	-	6	2024	c.1913G>A	c.(1912-1914)AGA>AAA	p.R638K	EXPH5_uc010rvy.1_Missense_Mutation_p.R450K|EXPH5_uc010rvz.1_Missense_Mutation_p.R482K|EXPH5_uc010rwa.1_Missense_Mutation_p.R562K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	638					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGGATTCCTTCTGTCATCAGA	0.408													0	0	0	0.024245	0	12	75										T	108384321	C	T	108384321	3	4	60	1	0	0	0	0	1	0	0	0	5322	913	32	1	4060	1	EXPH5	11	108384321	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	15768060	108384321	26622195	138	17407										
HSPB2	3316	broad.mit.edu	37	chr11	111784264	111784264	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gggcagcagggcaggggcctCcgagcttaggctcagtgagg	19	10	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:111784264C>A	uc001pmg.2	+	2	288	c.194C>A	c.(193-195)TCC>TAC	p.S65Y	CRYAB_uc001pmf.1_5'Flank|CRYAB_uc010rwp.1_5'Flank|HSPB2_uc009yyj.2_RNA|C11orf52_uc001pmh.2_Intron	NM_001541	NP_001532	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	65					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			ovary(2)|skin(1)	3		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		GCAGGGGCCTCCGAGCTTAGG	0.622													1	0	0.000157383	0.038147	0.000165761	7	106										A	111784264	C	A	111784264	3	1	60	1	0	0	0	0	1	0	0	0	7420	855	30	3	200	3	HSPB2	11	111784264	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	3399943	111784264	23222252	139	17408										
USP28	57646	broad.mit.edu	37	chr11	113683113	113683113	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	caggaagattcagtaacagaGatgtcattgtacttgagcca	10	7	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:113683113G>A	uc001poh.2	-	16	1890	c.1857C>T	c.(1855-1857)ATC>ATT	p.I619I	USP28_uc001pog.2_Silent_p.I327I|USP28_uc010rwy.1_Silent_p.I494I|USP28_uc001poi.2_5'UTR	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	619					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		CAGTAACAGAGATGTCATTGT	0.418													0	0	0	0.058154	0	10	77										A	113683113	G	A	113683113	2	1	60	1	0	0	0	0	0	0	0	1	17055	932	33	1		1	USP28	11	113683113	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	1898849	113683113	21323403	140	17409										
FOXR1	283150	broad.mit.edu	37	chr11	118851213	118851213	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tccatagaaagcacttccccTttttccggacggccccggaa	8	15	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:118851213T>C	uc001pui.2	+	5	850	c.625T>C	c.(625-627)TTT>CTT	p.F209L	FOXR1_uc001puj.2_Intron|FOXR1_uc001puk.2_Missense_Mutation_p.F40L	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1	209	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCACTTCCCCTTTTTCCGGAC	0.562													0	0	0	0.009096	0	3	74										C	118851213	T	C	118851213	3	2	60	1	0	0	0	0	1	0	0	0	6031	1609	56	5	643	5	FOXR1	11	118851213	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	5168100	118851213	16155303	141	17410										
OR8B8	26493	broad.mit.edu	37	chr11	124310774	124310774	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aacactggaatagcagaaatCtatgaaggacaagttataga	9	5	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr11:124310774C>A	uc010sal.1	-	1	208	c.208G>T	c.(208-210)GAT>TAT	p.D70Y		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TAGCAGAAATCTATGAAGGAC	0.453													1	0	0.000602214	0.014758	0.000629484	5	56										A	124310774	C	A	124310774	3	1	60	1	0	0	0	0	1	0	0	0	11230	913	32	3	730	3	OR8B8	11	124310774	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	5459561	124310774	10695742	142	17411										
WNK1	65125	broad.mit.edu	37	chr12	970296	970297	+	Frame_Shift_Ins	INS	-	-	A													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gttggtacgggaggagcaagINSaaaaaaaaaagcaggaagag							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:970296_970297insA	uc001qio.3	+	7	2245_2246	c.1738_1739insA	c.(1738-1740)GAAfs	p.E580fs	WNK1_uc001qip.3_Frame_Shift_Ins_p.E580fs|WNK1_uc001qir.3_Frame_Shift_Ins_p.E27fs	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	580					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GGAGGAGCAAGAAAAAAAAAAG	0.47																		7	97	---	---								A	970297	-	A	970296	7	5	60	1	0	1	1	0	0	0	0	0	17374	943	33	0	1764	0	WNK1	12	970296	Frame_Shift_Ins	INS	-	TCGA-DK-A3IQ-01A-31D-A20D-08		970296	132881599	143	17412										
CLEC4A	50856	broad.mit.edu	37	chr12	8288244	8288244	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttccaactgctactttatttCtactgaatcagcatcttggc	5	11	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:8288244C>G	uc001qtz.1	+	4	609	c.362C>G	c.(361-363)TCT>TGT	p.S121C	CLEC4A_uc009zga.1_Missense_Mutation_p.S82C|CLEC4A_uc001qub.1_Missense_Mutation_p.S88C|CLEC4A_uc001quc.1_Missense_Mutation_p.S49C|CLEC4A_uc009zgb.1_Intron|uc010sgi.1_5'Flank	NM_016184	NP_057268	Q9UMR7	CLC4A_HUMAN	C-type lectin domain family 4, member A isoform	121	Extracellular (Potential).|C-type lectin.				cell adhesion|cell surface receptor linked signaling pathway|innate immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0				Kidney(36;0.0915)		TACTTTATTTCTACTGAATCA	0.438													0	0	0	0.004672	0	3	69										G	8288244	C	G	8288244	3	3	60	1	0	0	0	0	1	0	0	0	3512	913	32	1	376	1	CLEC4A	12	8288244	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	7317948	8288244	125563651	144	17413										
EPS8	2059	broad.mit.edu	37	chr12	15815014	15815014	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggtgtttcttcctgctcatgAtactgccttggtttctcaac	8	11	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:15815014A>G	uc009zif.2	-	9	850	c.756T>C	c.(754-756)TAT>TAC	p.Y252Y	EPS8_uc001rdb.2_Silent_p.Y252Y|EPS8_uc009zig.2_5'UTR|EPS8_uc010shv.1_5'UTR	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	252					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		CCTGCTCATGATACTGCCTTG	0.383													0	0	0	0.009096	0	3	136										G	15815014	A	G	15815014	2	3	60	1	0	0	0	0	0	0	0	1	5194	340	12	5		5	EPS8	12	15815014	Silent	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	7526770	15815014	118036881	145	17414										
SOX5	6660	broad.mit.edu	37	chr12	24048864	24048864	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtgaaaggctgggagcccgtCactctcctcttcttccactt	9	14	4	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:24048864C>A	uc001rfw.2	-	2	235	c.133G>T	c.(133-135)GAC>TAC	p.D45Y	SOX5_uc001rfx.2_Missense_Mutation_p.D32Y|SOX5_uc001rfy.2_Missense_Mutation_p.D32Y|SOX5_uc010siv.1_Missense_Mutation_p.D32Y|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.D32Y|SOX5_uc001rga.2_Missense_Mutation_p.D45Y	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	45					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GGGAGCCCGTCACTCTCCTCT	0.527													1	0	1.04594e-18	0.086207	1.20719e-18	35	183										A	24048864	C	A	24048864	3	1	60	1	0	0	0	0	1	0	0	0	14954	826	29	3	2224	3	SOX5	12	24048864	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	8233850	24048864	109803031	146	17415										
KRT2	3849	broad.mit.edu	37	chr12	53044194	53044194	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtgatgttctttctgcagtGagcccatccagatatctctt	8	10	3	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:53044194G>A	uc001sat.2	-	2	762	c.729C>T	c.(727-729)CTC>CTT	p.L243L		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	243	Coil 1B.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		TTTCTGCAGTGAGCCCATCCA	0.488													0	0	0	0.048971	0	47	177										A	53044194	G	A	53044194	2	1	60	1	0	0	0	0	0	0	0	1	8457	1277	45	1		1	KRT2	12	53044194	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	28995330	53044194	80807701	147	17416										
SLC26A10	65012	broad.mit.edu	37	chr12	58017661	58017661	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cagtggtcctgtcggtgctgCtgtggctggggcccttcttt	15	11	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:58017661C>T	uc001spe.2	+	8	1407	c.1096C>T	c.(1096-1098)CTG>TTG	p.L366L	SLC26A10_uc001spf.2_RNA|SLC26A10_uc009zpz.1_5'Flank	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	366	Helical; (Potential).					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					GTCGGTGCTGCTGTGGCTGGG	0.562													0	0	0	0.024245	0	14	84										T	58017661	C	T	58017661	2	4	60	1	0	0	0	0	0	0	0	1	14515	796	28	2		2	SLC26A10	12	58017661	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	4973467	58017661	75834234	148	17417										
USP15	9958	broad.mit.edu	37	chr12	62783261	62783261	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atattagatctttgtacagcAttgtctgctttgtcaggaat	8	6	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:62783261A>G	uc001src.1	+	12	1533	c.1524A>G	c.(1522-1524)GCA>GCG	p.A508A	USP15_uc001srb.1_Silent_p.A479A	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	508					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TTTGTACAGCATTGTCTGCTT	0.308													0	0	0	0.0333	0	14	51										G	62783261	A	G	62783261	2	3	60	1	0	0	0	0	0	0	0	1	17043	204	8	5		5	USP15	12	62783261	Silent	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	4765600	62783261	71068634	149	17418										
USP15	9958	broad.mit.edu	37	chr12	62798096	62798096	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcatcccattagaaagtgatGaagatagcaatgataatgac	9	6	0	6			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:62798096G>A	uc001src.1	+	22	2896	c.2887G>A	c.(2887-2889)GAA>AAA	p.E963K	USP15_uc001srb.1_Missense_Mutation_p.E934K	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	963					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AGAAAGTGATGAAGATAGCAA	0.403													0	0	0	0.020292	0	14	46										A	62798096	G	A	62798096	3	1	60	1	0	0	0	0	1	0	0	0	17043	1291	45	1	2882	1	USP15	12	62798096	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	14835	62798096	71053799	150	17419										
GRIP1	23426	broad.mit.edu	37	chr12	66770815	66770815	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	accaagagagtcatgtttctCaaagacacacgcctgtcagc	8	12	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:66770815C>T	uc001stk.2	-	21	2845	c.2604G>A	c.(2602-2604)TTG>TTA	p.L868L	GRIP1_uc010sta.1_Silent_p.L812L|GRIP1_uc001stj.2_Intron|GRIP1_uc001stl.1_Intron|GRIP1_uc001stm.2_Intron	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	920					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TCATGTTTCTCAAAGACACAC	0.393													0	0	0	0.028581	0	15	95										T	66770815	C	T	66770815	2	4	60	1	0	0	0	0	0	0	0	1	6787	825	29	1		1	GRIP1	12	66770815	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	3972719	66770815	67081080	151	17420										
DUSP6	1848	broad.mit.edu	37	chr12	89744602	89744603	+	Frame_Shift_Ins	INS	-	-	G													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gggaaggaaggctggctgttINSggacagcggactaccatccg							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:89744602_89744603insG	uc001tay.2	-	2	1080_1081	c.600_601insC	c.(598-603)TCCAACfs	p.S200fs	DUSP6_uc001taz.2_Intron	NM_001946	NP_001937	Q16828	DUS6_HUMAN	dual specificity phosphatase 6 isoform a	200_201					dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						GGCTGGCTGTTGGACAGCGGAC	0.564																		19	139	---	---								G	89744603	-	G	89744602	7	5	60	1	0	1	1	0	0	0	0	0	4829	1812	63	0	552	0	DUSP6	12	89744602	Frame_Shift_Ins	INS	-	TCGA-DK-A3IQ-01A-31D-A20D-08	22973787	89744602	44107293	152	17421										
ATP2B1	490	broad.mit.edu	37	chr12	90036059	90036059	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aattgaagaaaggtttttggCtttttaggaggtataaaatt	10	1	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:90036059C>G	uc001tbh.2	-	2	463	c.282G>C	c.(280-282)AAG>AAC	p.K94N	ATP2B1_uc001tbg.2_Missense_Mutation_p.K94N	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	94	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						AGGTTTTTGGCTTTTTAGGAG	0.318													0	0	0	0.048971	0	41	241										G	90036059	C	G	90036059	3	3	60	1	0	0	0	0	1	0	0	0	1139	796	28	4	3614	4	ATP2B1	12	90036059	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	291457	90036059	43815836	153	17422										
EEA1	8411	broad.mit.edu	37	chr12	93247696	93247696	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttaagtaaagttacctgctGatgaatcagtcaccaaccca	6	10	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:93247696G>A	uc001tck.2	-	6	666	c.401C>T	c.(400-402)TCA>TTA	p.S134L		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	134	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						GTTACCTGCTGATGAATCAGT	0.308													0	0	0	0.047766	0	8	28										A	93247696	G	A	93247696	3	1	60	1	0	0	0	0	1	0	0	0	4921	1294	45	1	3930	1	EEA1	12	93247696	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3211637	93247696	40604199	154	17423										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100453074	100453074	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttggtatcttgttcatgagCatgtctctggaaaattggat	10	5	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:100453074C>T	uc001tgq.2	-	14	2210	c.1981G>A	c.(1981-1983)GCT>ACT	p.A661T	UHRF1BP1L_uc001tgp.2_Missense_Mutation_p.A311T	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	661										ovary(2)	2						TGTTCATGAGCATGTCTCTGG	0.318													0	0	0	0.004672	0	3	56										T	100453074	C	T	100453074	3	4	60	1	0	0	0	0	1	0	0	0	16966	710	25	2	2445	2	UHRF1BP1L	12	100453074	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	7205378	100453074	33398821	155	17424										
BTBD11	121551	broad.mit.edu	37	chr12	108006588	108006588	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cctgatgtatgcctgcgtccGtggggacgaggcgatggttc	16	10	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:108006588G>A	uc001tmk.1	+	6	2362	c.1841G>A	c.(1840-1842)CGT>CAT	p.R614H	BTBD11_uc009zut.1_Missense_Mutation_p.R614H|BTBD11_uc001tmj.2_Missense_Mutation_p.R614H|BTBD11_uc001tml.1_Missense_Mutation_p.R151H	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	614	ANK 1.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						GCCTGCGTCCGTGGGGACGAG	0.577													0	0	0	0.058154	0	7	41										A	108006588	G	A	108006588	3	1	60	1	0	0	0	0	1	0	0	0	1539	1145	40	2	1968	2	BTBD11	12	108006588	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	7553514	108006588	25845307	156	17425										
NOS1	4842	broad.mit.edu	37	chr12	117698400	117698400	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cctgccccatcagcttggccGagaacttgacagctctggag	11	14	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:117698400G>C	uc001twm.1	-	14	2923	c.2237C>G	c.(2236-2238)TCG>TGG	p.S746W	NOS1_uc001twn.1_5'Flank	NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	746	Calmodulin-binding (Potential).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CAGCTTGGCCGAGAACTTGAC	0.522													0	0	0	0.014758	0	4	31										C	117698400	G	C	117698400	3	2	60	1	0	0	0	0	1	0	0	0	10541	1059	37	1	2131	1	NOS1	12	117698400	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	9691812	117698400	16153495	157	17426										
CLIP1	6249	broad.mit.edu	37	chr12	122825899	122825899	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cttccatagagctatcacatCtgagttctctttgttggcat	7	10	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:122825899C>T	uc001ucg.1	-	10	1958	c.1852G>A	c.(1852-1854)GAT>AAT	p.D618N	CLIP1_uc001uch.1_Missense_Mutation_p.D607N|CLIP1_uc001uci.1_Missense_Mutation_p.D572N|CLIP1_uc001ucj.1_Missense_Mutation_p.D308N|CLIP1_uc009zxo.1_Missense_Mutation_p.D174N	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	618	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GCTATCACATCTGAGTTCTCT	0.478													0	0	0	0.049695	0	18	67										T	122825899	C	T	122825899	3	4	60	1	0	0	0	0	1	0	0	0	3532	913	32	1	2528	1	CLIP1	12	122825899	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	5127499	122825899	11025996	158	17427										
POLE	5426	broad.mit.edu	37	chr12	133257231	133257231	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atcttgaataaagtagtaatCcactgcactgcctaagcgct	7	10	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr12:133257231C>G	uc001uks.1	-	3	291	c.247G>C	c.(247-249)GAT>CAT	p.D83H	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Intron	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	83					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		AAGTAGTAATCCACTGCACTG	0.428								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.028581	0	15	64										G	133257231	C	G	133257231	3	3	60	1	0	0	0	0	1	0	0	0	12196	855	30	1	6801	1	POLE	12	133257231	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	10431332	133257231	594664	159	17428										
PAN3	255967	broad.mit.edu	37	chr13	28834599	28834599	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttaggtgtttccaaactatCatatttatcctccaactgca	4	10	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr13:28834599C>T	uc001urz.2	+	7	834	c.826C>T	c.(826-828)CAT>TAT	p.H276Y	PAN3_uc010tdo.1_Missense_Mutation_p.H422Y|PAN3_uc001ury.2_Missense_Mutation_p.H110Y|PAN3_uc001urx.2_Missense_Mutation_p.H222Y	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	422	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TCCAAACTATCATATTTATCC	0.323													0	0	0	0.030593	0	24	56										T	28834599	C	T	28834599	3	4	60	1	0	0	0	0	1	0	0	0	11415	826	29	1	1294	1	PAN3	13	28834599	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		28834599	86335279	160	17429										
FRY	10129	broad.mit.edu	37	chr13	32745308	32745308	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	catcacacactccttgattcGtccctgaagttgctgctgca	7	14	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr13:32745308G>A	uc001utx.2	+	18	2548	c.2052G>A	c.(2050-2052)TCG>TCA	p.S684S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	684					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCCTTGATTCGTCCCTGAAGT	0.443													0	0	0	0.080422	0	30	51										A	32745308	G	A	32745308	2	1	60	1	0	0	0	0	0	0	0	1	6063	1132	40	2		2	FRY	13	32745308	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3910709	32745308	82424570	161	17430										
ATP11A	23250	broad.mit.edu	37	chr13	113532571	113532571	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtcgagcagtcaaccatctTtatgctttctcagacttcca	6	12	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr13:113532571T>A	uc001vsi.3	+	29	3456	c.3368T>A	c.(3367-3369)TTT>TAT	p.F1123Y	ATP11A_uc001vsj.3_Intron|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1123	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TCAACCATCTTTATGCTTTCT	0.547													0	0	0	0.014758	0	4	80										A	113532571	T	A	113532571	3	1	60	1	0	0	0	0	1	0	0	0	1119	1841	64	5	3482	5	ATP11A	13	113532571	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	80787263	113532571	1637307	162	17431										
ADPRHL1	113622	broad.mit.edu	37	chr13	114077230	114077230	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tggtacaagcctttgggaacGaggtccaggccgtacagcaa	13	10	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr13:114077230G>A	uc001vtq.1	-	7	1059	c.972C>T	c.(970-972)CTC>CTT	p.L324L	ADPRHL1_uc001vtp.1_Silent_p.L242L	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	324					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTTTGGGAACGAGGTCCAGGC	0.617													0	0	0	0.045705	0	27	83										A	114077230	G	A	114077230	2	1	60	1	0	0	0	0	0	0	0	1	332	1045	37	1		1	ADPRHL1	13	114077230	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	544659	114077230	1092648	163	17432										
REC8	9985	broad.mit.edu	37	chr14	24648055	24648055	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acccccaaaagccctcaggcGagagctgcctgaggaggcag	13	14	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr14:24648055G>A	uc001wmr.2	+	16	1563	c.1136G>A	c.(1135-1137)CGA>CAA	p.R379Q	REC8_uc001wms.2_Missense_Mutation_p.R379Q	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	379	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		GCCCTCAGGCGAGAGCTGCCT	0.582													0	0	0	0.105934	0	14	186										A	24648055	G	A	24648055	3	1	60	1	0	0	0	0	1	0	0	0	13199	1058	37	1	1187	1	REC8	14	24648055	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		24648055	82701485	164	17433										
CDKL1	8814	broad.mit.edu	37	chr14	50845041	50845041	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtgcctgagtagggcaataaGgttcttgctctgcgaggaaa	14	7	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr14:50845041G>A	uc010anu.1	-	9	1208	c.1208C>T	c.(1207-1209)CCT>CTT	p.P403L	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					agggcaataaggttcttgctc	0													0	0	0	0.020292	0	13	23										A	50845041	G	A	50845041	3	1	60	1	0	0	0	0	1	0	0	0	3153	1015	35	2		2	CDKL1	14	50845041	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	26196986	50845041	56504499	165	17434										
ARID4A	5926	broad.mit.edu	37	chr14	58831244	58831244	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttataaagatttcatcatttGgccagaatgaagcaggaagt	9	5	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr14:58831244G>T	uc001xdp.2	+	20	2691	c.2437G>T	c.(2437-2439)GGC>TGC	p.G813C	ARID4A_uc001xdo.2_Missense_Mutation_p.G813C|ARID4A_uc001xdq.2_Missense_Mutation_p.G813C|ARID4A_uc010apg.1_Missense_Mutation_p.G491C	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	813					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TTCATCATTTGGCCAGAATGA	0.333													1	0	2.74318e-10	0.058154	3.07636e-10	8	22										T	58831244	G	T	58831244	3	4	60	1	0	0	0	0	1	0	0	0	919	1348	47	4	2511	4	ARID4A	14	58831244	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	7986203	58831244	48518296	166	17435										
C14orf68	283600	broad.mit.edu	37	chr14	100795895	100795895	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cttttcaaggggctggtactCaattgctgccgcgccttccc	10	14	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr14:100795895C>G	uc001yhc.2	+	6	913	c.840C>G	c.(838-840)CTC>CTG	p.L280L	C14orf68_uc001yhd.2_Silent_p.L134L	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	280	Helical; Name=6; (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				GGCTGGTACTCAATTGCTGCC	0.647													0	0	0	0.045705	0	27	83										G	100795895	C	G	100795895	2	3	60	1	0	0	0	0	0	0	0	1	1778	813	29	1		1	C14orf68	14	100795895	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	41964651	100795895	6553645	167	17436										
CEP152	22995	broad.mit.edu	37	chr15	49074365	49074365	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cttgttcatgtttgcactcaTagcatgtgccttctgtgctt	8	10	3	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr15:49074365T>C	uc001zwy.2	-	11	1418	c.1384A>G	c.(1384-1386)ATG>GTG	p.M462V	CEP152_uc001zwz.2_Missense_Mutation_p.M462V|CEP152_uc001zxa.1_Missense_Mutation_p.M369V	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	462	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TTTGCACTCATAGCATGTGCC	0.393													0	0	0	0.020292	0	10	61										C	49074365	T	C	49074365	3	2	60	1	0	0	0	0	1	0	0	0	3248	1406	49	5	3644	5	CEP152	15	49074365	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08		49074365	53457027	168	17437										
SECISBP2L	9728	broad.mit.edu	37	chr15	49285034	49285034	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tggaagtttactgggtttttCagaagtgctgtgcttacagg	13	5	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr15:49285034C>T	uc001zxe.1	-	18	2847	c.2713G>A	c.(2713-2715)GAA>AAA	p.E905K	SECISBP2L_uc001zxd.1_Missense_Mutation_p.E860K	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	905										breast(1)|skin(1)	2						CTGGGTTTTTCAGAAGTGCTG	0.433													0	0	0	0.034045	0	27	95										T	49285034	C	T	49285034	3	4	60	1	0	0	0	0	1	0	0	0	14007	835	29	1	596	1	SECISBP2L	15	49285034	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	210669	49285034	53246358	169	17438										
MYO1E	4643	broad.mit.edu	37	chr15	59500904	59500904	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccagcataatgatgaatgatGaagccttggttccaactgtt	9	8	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr15:59500904G>A	uc002aga.2	-	14	1878	c.1506C>T	c.(1504-1506)TTC>TTT	p.F502F		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	502	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		GATGAATGATGAAGCCTTGGT	0.453													0	0	0	0.069234	0	8	150										A	59500904	G	A	59500904	2	1	60	1	0	0	0	0	0	0	0	1	10072	1281	45	1		1	MYO1E	15	59500904	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	10215870	59500904	43030488	170	17439										
C15orf42	90381	broad.mit.edu	37	chr15	90119305	90119305	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cctggccccctgtccgcactCgcagagggagctgctgcagt	13	16	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr15:90119305C>T	uc002boe.2	+	1	488	c.488C>T	c.(487-489)TCG>TTG	p.S163L		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	163					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TGTCCGCACTCGCAGAGGGAG	0.682													0	0	0	0.009096	0	3	23										T	90119305	C	T	90119305	3	4	60	1	0	0	0	0	1	0	0	0	1796	893	31	1	490	1	C15orf42	15	90119305	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	30618401	90119305	12412087	171	17440										
SYNM	23336	broad.mit.edu	37	chr15	99670051	99670051	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	caaatgagaggaccgtcattCtgggaaagaaaacagaagtg	12	6	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr15:99670051C>G	uc002bup.2	+	6	1606	c.1486C>G	c.(1486-1488)CTG>GTG	p.L496V	SYNM_uc002buo.2_Missense_Mutation_p.L496V|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	496	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						GACCGTCATTCTGGGAAAGAA	0.493													0	0	0	0.004672	0	3	21										G	99670051	C	G	99670051	3	3	60	1	0	0	0	0	1	0	0	0	15452	912	32	1	1499	1	SYNM	15	99670051	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	9550746	99670051	2861341	172	17441										
C16orf11	146325	broad.mit.edu	37	chr16	613542	613542	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccgccgtggctccaccacgcCtaggccccacgcacccaccc	8	24	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:613542C>T	uc002chk.2	+	2	527	c.248C>T	c.(247-249)CCT>CTT	p.P83L		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	83	Pro-rich.									central_nervous_system(1)	1						TCCACCACGCCTAGGCCCCAC	0.692													0	0	0	0.014758	0	4	23										T	613542	C	T	613542	3	4	60	1	0	0	0	0	1	0	0	0	1810	681	24	2	250	2	C16orf11	16	613542	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		613542	89741211	173	17442										
TELO2	9894	broad.mit.edu	37	chr16	1552951	1552951	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggtggccgactatctgacctCacagttctatgccctcaact	8	14	4	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:1552951C>T	uc002cly.2	+	15	2081	c.1790C>T	c.(1789-1791)TCA>TTA	p.S597L		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	597						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				TATCTGACCTCACAGTTCTAT	0.657													0	0	0	0.028581	0	12	137										T	1552951	C	T	1552951	3	4	60	1	0	0	0	0	1	0	0	0	15754	838	29	1	1844	1	TELO2	16	1552951	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	939409	1552951	88801802	174	17443										
NTHL1	4913	broad.mit.edu	37	chr16	2094652	2094652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctccagaaaccgacggggtaGatgagcttgcccagcgtggc	14	12	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:2094652G>C	uc002col.1	-	3	547	c.528C>G	c.(526-528)ATC>ATG	p.I176M	NTHL1_uc002com.1_Missense_Mutation_p.I177M	NM_002528	NP_002519	P78549	NTHL1_HUMAN	nth endonuclease III-like 1	176					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						CGACGGGGTAGATGAGCTTGC	0.682								BER_DNA_glycosylases					0	0	0	0.02938	0	5	70										C	2094652	G	C	2094652	3	2	60	1	0	0	0	0	1	0	0	0	10698	932	33	1	426	1	NTHL1	16	2094652	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	541701	2094652	88260101	175	17444										
MEFV	4210	broad.mit.edu	37	chr16	3293384	3293384	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cgggtcgggggaacgctggaCgcctggtactcattttcctt	14	11	1	0	rs104895095		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:3293384C>T	uc002cun.1	-	10	2143	c.2103G>A	c.(2101-2103)GCG>GCA	p.A701A		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	701	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GAACGCTGGACGCCTGGTACT	0.517													0	0	0	0.024245	0	14	69										T	3293384	C	T	3293384	2	4	60	1	0	0	0	0	0	0	0	1	9459	523	19	2		2	MEFV	16	3293384	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1198732	3293384	87061369	176	17445										
ZNF75A	7627	broad.mit.edu	37	chr16	3367786	3367786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	accggagaacccacacaggtGagcagccatatacttgtagc	10	12	0	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:3367786G>C	uc002cut.3	+	6	1334	c.808G>C	c.(808-810)GAG>CAG	p.E270Q	ZNF75A_uc002cuv.3_RNA	NM_153028	NP_694573	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						CCACACAGGTGAGCAGCCATA	0.453													0	0	0	0.049695	0	17	70										C	3367786	G	C	3367786	3	2	60	1	0	0	0	0	1	0	0	0	18130	1291	45	1	818	1	ZNF75A	16	3367786	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	74402	3367786	86986967	177	17446										
ABCC6	368	broad.mit.edu	37	chr16	16276399	16276399	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agcacacattctctaccacaGaggtgttctgcacccaggcc	8	15	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:16276399G>A	uc002den.3	-	17	2154	c.2117C>T	c.(2116-2118)TCT>TTT	p.S706F	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	706	ABC transporter 1.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CTCTACCACAGAGGTGTTCTG	0.577													0	0	0	0.080935	0	10	51										A	16276399	G	A	16276399	3	1	60	1	0	0	0	0	1	0	0	0	57	942	33	1	2454	1	ABCC6	16	16276399	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	12908613	16276399	74078354	178	17447										
ATP2A1	487	broad.mit.edu	37	chr16	28913966	28913966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtacgctgaggatgggcctCatgtcaactacagccagctg	12	11	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:28913966C>G	uc002dro.1	+	18	2774	c.2590C>G	c.(2590-2592)CAT>GAT	p.H864D	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.H864D|ATP2A1_uc002drp.1_Missense_Mutation_p.H739D	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	864	Lumenal (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGATGGGCCTCATGTCAACTA	0.652													0	0	0	0.038395	0	14	54										G	28913966	C	G	28913966	3	3	60	1	0	0	0	0	1	0	0	0	1136	826	29	1	2660	1	ATP2A1	16	28913966	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	12637567	28913966	61440787	179	17448										
MAPK3	5595	broad.mit.edu	37	chr16	30129483	30129483	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gggccaggccgaaatcacaaAtctggaatcagacctagctg	11	11	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:30129483A>T	uc002dws.2	-	4	645	c.545T>A	c.(544-546)ATT>AAT	p.I182N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_Missense_Mutation_p.I68N|MAPK3_uc002dwv.3_Missense_Mutation_p.I182N|MAPK3_uc002dwt.2_Missense_Mutation_p.I182N|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	182	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GAAATCACAAATCTGGAATCA	0.592													0	0	0	0.038147	0	5	38										T	30129483	A	T	30129483	3	4	60	1	0	0	0	0	1	0	0	0	9279	115	4	5	671	5	MAPK3	16	30129483	Missense_Mutation	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	1215517	30129483	60225270	180	17449										
ITGAM	3684	broad.mit.edu	37	chr16	31341460	31341460	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctctcactccgactttctggCtgagcttcggaaggcccccg	10	16	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:31341460C>A	uc002ebq.2	+	26	3133	c.3035C>A	c.(3034-3036)GCT>GAT	p.A1012D	ITGAM_uc002ebr.2_Missense_Mutation_p.A1013D|ITGAM_uc010can.2_Missense_Mutation_p.A418D	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	1012	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GACTTTCTGGCTGAGCTTCGG	0.597													1	0	8.12818e-05	0.02938	8.59354e-05	6	22										A	31341460	C	A	31341460	3	1	60	1	0	0	0	0	1	0	0	0	7887	797	28	4	3140	4	ITGAM	16	31341460	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	1211977	31341460	59013293	181	17450										
NOL3	8996	broad.mit.edu	37	chr16	67208978	67208978	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aggccagagctctgacaggcGgtgccccgcccatgctggat	14	14	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:67208978G>A	uc010vjd.1	+	4	831	c.824G>A	c.(823-825)CGG>CAG	p.R275Q	NOL3_uc010vjc.1_3'UTR|NOL3_uc002erp.2_3'UTR			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	213					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		TCTGACAGGCGGTGCCCCGCC	0.612													0	0	0	0.069456	0	31	162										A	67208978	G	A	67208978	3	1	60	1	0	0	0	0	1	0	0	0	10523	1116	39	2	658	2	NOL3	16	67208978	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	35867518	67208978	23145775	182	17451										
NFATC3	4775	broad.mit.edu	37	chr16	68224692	68224692	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttgatgaagcaagaacacaGagaagagattgatttgtctt	10	4	1	6			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:68224692G>A	uc002evo.1	+	9	2330	c.2120G>A	c.(2119-2121)AGA>AAA	p.R707K	NFATC3_uc010vkl.1_Missense_Mutation_p.R228K|NFATC3_uc010vkm.1_Missense_Mutation_p.R228K|NFATC3_uc010vkn.1_Missense_Mutation_p.R228K|NFATC3_uc010vko.1_Missense_Mutation_p.R228K|NFATC3_uc010vkp.1_Missense_Mutation_p.R228K|NFATC3_uc010vkq.1_Missense_Mutation_p.R228K|NFATC3_uc002evl.2_Missense_Mutation_p.R228K|NFATC3_uc002evk.2_Missense_Mutation_p.R707K|NFATC3_uc002evm.1_Missense_Mutation_p.R707K|NFATC3_uc002evn.1_Missense_Mutation_p.R707K|NFATC3_uc010vkr.1_Missense_Mutation_p.R228K|NFATC3_uc010vks.1_Missense_Mutation_p.R228K|NFATC3_uc010vkt.1_Missense_Mutation_p.R228K|NFATC3_uc010vku.1_Missense_Mutation_p.R228K|NFATC3_uc010vkv.1_Missense_Mutation_p.R228K|NFATC3_uc010vkw.1_Missense_Mutation_p.R228K|NFATC3_uc010vkx.1_Missense_Mutation_p.R228K|NFATC3_uc010vky.1_Missense_Mutation_p.R228K|NFATC3_uc010vkz.1_Missense_Mutation_p.R228K|NFATC3_uc010vla.1_Missense_Mutation_p.R228K|NFATC3_uc010vlb.1_Missense_Mutation_p.R228K|NFATC3_uc010vlc.1_Missense_Mutation_p.R228K	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	707					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CAAGAACACAGAGAAGAGATT	0.388													0	0	0	0.02938	0	6	120										A	68224692	G	A	68224692	3	1	60	1	0	0	0	0	1	0	0	0	10364	942	33	1	2154	1	NFATC3	16	68224692	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	1015714	68224692	22130061	183	17452										
AARS	16	broad.mit.edu	37	chr16	70299548	70299548	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaacccataggtgtcatagaGgagccaagcagtgtctccta	10	10	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:70299548G>A	uc002eyn.1	-	10	1350	c.1240C>T	c.(1240-1242)CTC>TTC	p.L414F	AARS_uc010vlu.1_Missense_Mutation_p.L244F	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	414					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding	p.L414L(1)		pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	GTGTCATAGAGGAGCCAAGCA	0.507													0	0	0	0.105934	0	11	21										A	70299548	G	A	70299548	3	1	60	1	0	0	0	0	1	0	0	0	19	1000	35	2	1714	2	AARS	16	70299548	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	2074856	70299548	20055205	184	17453										
SF3B3	23450	broad.mit.edu	37	chr16	70562947	70562947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	caaagactacattgtagttgGcagtgactctggtcgaattg	11	7	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:70562947G>A	uc002ezf.2	+	3	453	c.242G>A	c.(241-243)GGC>GAC	p.G81D	SNORD111B_uc010cfv.1_5'Flank	NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	81					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				ATTGTAGTTGGCAGTGACTCT	0.458													0	0	0	0.09319	0	12	79										A	70562947	G	A	70562947	3	1	60	1	0	0	0	0	1	0	0	0	14152	1203	42	2	248	2	SF3B3	16	70562947	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	263399	70562947	19791806	185	17454										
ZC3H18	124245	broad.mit.edu	37	chr16	88694357	88694357	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agaaagaagacggtgttaaaGaggaaaagcggaaaagggat	15	2	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:88694357G>C	uc002fky.2	+	15	2499	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	ZC3H18_uc010voz.1_Missense_Mutation_p.E791Q|ZC3H18_uc010chw.2_Intron|ZC3H18_uc002fkz.2_Missense_Mutation_p.E37Q	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	767						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CGGTGTTAAAGAGGAAAAGCG	0.522													0	0	0	0.024245	0	13	75										C	88694357	G	C	88694357	3	2	60	1	0	0	0	0	1	0	0	0	17565	943	33	1	2353	1	ZC3H18	16	88694357	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	18131410	88694357	1660396	186	17455										
SPIRE2	84501	broad.mit.edu	37	chr16	89925754	89925754	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgtgtggaggcccggctcccGagaccagggcaagtgctgct	16	12	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr16:89925754G>C	uc002foz.1	+	9	1506	c.1454G>C	c.(1453-1455)CGA>CCA	p.R485P	SPIRE2_uc010civ.1_Missense_Mutation_p.R400P|SPIRE2_uc010ciw.1_Missense_Mutation_p.R485P|SPIRE2_uc002fpa.1_Missense_Mutation_p.R437P|SPIRE2_uc010cix.1_Missense_Mutation_p.R352P	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	485					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CCCGGCTCCCGAGACCAGGGC	0.697													0	0	0	0.004672	0	2	14										C	89925754	G	C	89925754	3	2	60	1	0	0	0	0	1	0	0	0	15071	1058	37	1	1488	1	SPIRE2	16	89925754	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	1231397	89925754	428999	187	17456										
KIAA0664	23277	broad.mit.edu	37	chr17	2601720	2601720	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	taggccgccacgtcccccccGaagtccttgtagtggtctcg	11	16	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:2601720G>A	uc002fuy.1	-	10	1403	c.1317C>T	c.(1315-1317)TTC>TTT	p.F439F	KIAA0664_uc002fux.1_Silent_p.F371F	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	439							binding			breast(2)	2						CGTCCCCCCCGAAGTCCTTGT	0.622													0	0	0	0.105934	0	11	17										A	2601720	G	A	2601720	2	1	60	1	0	0	0	0	0	0	0	1	8189	1049	37	1		1	KIAA0664	17	2601720	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		2601720	78593490	188	17457										
KIAA0664	23277	broad.mit.edu	37	chr17	2603983	2603983	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgcaggcacctgtccaggaaTgtgctcctcatagcccagcc	10	15	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:2603983T>C	uc002fuy.1	-	8	1134	c.1048A>G	c.(1048-1050)ATT>GTT	p.I350V	KIAA0664_uc002fux.1_Missense_Mutation_p.I282V	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	350							binding			breast(2)	2						TGTCCAGGAATGTGCTCCTCA	0.662													0	0	0	0.014758	0	4	35										C	2603983	T	C	2603983	3	2	60	1	0	0	0	0	1	0	0	0	8189	1464	51	5	2957	5	KIAA0664	17	2603983	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	2263	2603983	78591227	189	17458										
ABHD15	116236	broad.mit.edu	37	chr17	27889911	27889911	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gggtccacacacggggtcgtCagcactgcagatacacagca	12	13	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:27889911C>T	uc002hed.1	-	2	1139	c.1075G>A	c.(1075-1077)GAC>AAC	p.D359N		NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	359						extracellular region	carboxylesterase activity				0						ACGGGGTCGTCAGCACTGCAG	0.602													0	0	0	0.058154	0	9	69										T	27889911	C	T	27889911	3	4	60	1	0	0	0	0	1	0	0	0	81	826	29	1	335	1	ABHD15	17	27889911	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	25285928	27889911	53305299	190	17459										
SUZ12	23512	broad.mit.edu	37	chr17	30315444	30315444	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cggctcctattgccaaacctCttgccactagaaattcagag	7	13	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:30315444C>T	uc002hgs.2	+	10	1351	c.1129C>T	c.(1129-1131)CTT>TTT	p.L377F	SUZ12_uc002hgt.2_Missense_Mutation_p.L354F	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	377					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TGCCAAACCTCTTGCCACTAG	0.413			T	JAZF1	endometrial stromal tumours								0	0	0	0.047766	0	8	41										T	30315444	C	T	30315444	3	4	60	1	0	0	0	0	1	0	0	0	15413	913	32	1	1167	1	SUZ12	17	30315444	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2425533	30315444	50879766	191	17460										
POLG2	11232	broad.mit.edu	37	chr17	62486958	62486958	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tacatgtgtaaaagttcgtgAtctcctaggttccacagggt	10	8	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:62486958A>C	uc002jei.2	-	4	1007	c.924T>G	c.(922-924)GAT>GAG	p.D308E	POLG2_uc010deg.1_Missense_Mutation_p.D308E	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	308					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			AAAGTTCGTGATCTCCTAGGT	0.393													0	0	0	0.069234	0	9	101										C	62486958	A	C	62486958	3	2	60	1	0	0	0	0	1	0	0	0	12201	330	12	5	553	5	POLG2	17	62486958	Missense_Mutation	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	32171514	62486958	18708252	192	17461										
RGS9	8787	broad.mit.edu	37	chr17	63173909	63173909	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtgaccaatccgaatgaagtCaaggtaaaccaggtatgtct	10	8	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:63173909C>G	uc002jfe.2	+	9	752	c.642C>G	c.(640-642)GTC>GTG	p.V214V	RGS9_uc010dem.2_Silent_p.V214V|RGS9_uc002jfd.2_Silent_p.V214V|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	214					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CGAATGAAGTCAAGGTAAACC	0.493													0	0	0	0.064281	0	33	130										G	63173909	C	G	63173909	2	3	60	1	0	0	0	0	0	0	0	1	13313	813	29	1		1	RGS9	17	63173909	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	686951	63173909	18021301	193	17462										
BPTF	2186	broad.mit.edu	37	chr17	65907091	65907091	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cagagtcacatgtaaattgtCaggagagttctcaagtagat	10	6	3	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:65907091C>A	uc002jgf.2	+	11	3152	c.3091C>A	c.(3091-3093)CAG>AAG	p.Q1031K	BPTF_uc002jge.2_Missense_Mutation_p.Q1157K	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1157					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTAAATTGTCAGGAGAGTTC	0.383													1	0	0.000274275	0.047766	0.000287781	9	62										A	65907091	C	A	65907091	3	1	60	1	0	0	0	0	1	0	0	0	1495	827	29	3	3519	3	BPTF	17	65907091	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2733182	65907091	15288119	194	17463										
TTYH2	94015	broad.mit.edu	37	chr17	72233573	72233573	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ggcagcgttgttgttcagctCtcaggactgcccgtgtggag	15	10	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:72233573C>G	uc002jkc.2	+	4	586	c.555C>G	c.(553-555)CTC>CTG	p.L185L	TTYH2_uc010wqw.1_Silent_p.L164L	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	185	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						TTGTTCAGCTCTCAGGACTGC	0.602													0	0	0	0.038147	0	6	83										G	72233573	C	G	72233573	2	3	60	1	0	0	0	0	0	0	0	1	16737	900	32	1		1	TTYH2	17	72233573	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	6326482	72233573	8961637	195	17464										
TMEM104	54868	broad.mit.edu	37	chr17	72781647	72781647	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctggtgtacatgtttaacctCatcgtgggcacgggcgcact	12	11	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:72781647C>T	uc002jls.3	+	3	234	c.72C>T	c.(70-72)CTC>CTT	p.L24L	TMEM104_uc010wrf.1_Silent_p.L24L|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Silent_p.L24L	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	24	Helical; (Potential).					integral to membrane					0	all_lung(278;0.23)					TGTTTAACCTCATCGTGGGCA	0.572													0	0	0	0.069288	0	21	195										T	72781647	C	T	72781647	2	4	60	1	0	0	0	0	0	0	0	1	16015	813	29	1		1	TMEM104	17	72781647	Silent	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	548074	72781647	8413563	196	17465										
TSEN54	283989	broad.mit.edu	37	chr17	73512921	73512921	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgcccgacggctcggcagctCaggccgagcggctgcgccgg	17	16	1	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:73512921C>T	uc002jof.1	+	2	184	c.151C>T	c.(151-153)CAG>TAG	p.Q51*	CASKIN2_uc002joc.2_5'Flank|CASKIN2_uc002jod.2_5'Flank|TSEN54_uc002joe.1_Nonsense_Mutation_p.Q51*	NM_207346	NP_997229	Q7Z6J9	SEN54_HUMAN	tRNA splicing endonuclease 54 homolog	51					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	nucleolus				ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTCGGCAGCTCAGGCCGAGCG	0.736													0	0	0	0.004672	0	3	15										T	73512921	C	T	73512921	4	4	60	1	0	0	0	0	0	1	0	0	16611	827	29	1	157	1	TSEN54	17	73512921	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	731274	73512921	7682289	197	17466										
METRNL	284207	broad.mit.edu	37	chr17	81052039	81052039	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agcaagttacccacgagcctGagcggcaggactcagccatc	11	14	1	1	rs147805686		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr17:81052039G>A	uc002kgh.2	+	4	780	c.655G>A	c.(655-657)GAG>AAG	p.E219K	METRNL_uc002kgi.2_Missense_Mutation_p.E137K	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	219						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			CCACGAGCCTGAGCGGCAGGA	0.637													0	0	0	0.021553	0	4	167										A	81052039	G	A	81052039	3	1	60	1	0	0	0	0	1	0	0	0	9489	1291	45	1	669	1	METRNL	17	81052039	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	7539118	81052039	143171	198	17467										
ZNF521	25925	broad.mit.edu	37	chr18	22807156	22807156	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctgcacttctgagtgtccttCatcttccagtcctccatcct	5	16	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr18:22807156C>T	uc002kvk.2	-	4	973	c.726G>A	c.(724-726)ATG>ATA	p.M242I	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.M242I|ZNF521_uc002kvl.2_Missense_Mutation_p.M22I	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	242					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GAGTGTCCTTCATCTTCCAGT	0.527			T	PAX5	ALL								0	0	0	0.024245	0	16	59										T	22807156	C	T	22807156	3	4	60	1	0	0	0	0	1	0	0	0	17962	826	29	1	3229	1	ZNF521	18	22807156	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		22807156	55270092	199	17468										
DSG1	1828	broad.mit.edu	37	chr18	28908201	28908201	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agttacataccgcatctctgGagtaggaattgatcagccac	9	10	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr18:28908201G>C	uc002kwp.2	+	4	478	c.266G>C	c.(265-267)GGA>GCA	p.G89A		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	89	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CGCATCTCTGGAGTAGGAATT	0.388													0	0	0	0.0333	0	15	65										C	28908201	G	C	28908201	3	2	60	1	0	0	0	0	1	0	0	0	4776	1174	41	1	280	1	DSG1	18	28908201	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6101045	28908201	49169047	200	17469										
RTTN	25914	broad.mit.edu	37	chr18	67816249	67816249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aaggagaatgcagttacccaGaggatcttctgtgtcggcat	12	8	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr18:67816249G>C	uc002lkp.2	-	17	2265	c.2197C>G	c.(2197-2199)CTG>GTG	p.L733V	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	733							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CAGTTACCCAGAGGATCTTCT	0.368													0	0	0	0.076483	0	19	91										C	67816249	G	C	67816249	3	2	60	1	0	0	0	0	1	0	0	0	13737	933	33	1	4615	1	RTTN	18	67816249	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	38908048	67816249	10260999	201	17470										
MYO1F	4542	broad.mit.edu	37	chr19	8617036	8617036	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acctcggctgaactggatctCaaagtacttgccctgaatcc	8	13	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:8617036C>G	uc002mkg.2	-	7	631	c.517G>C	c.(517-519)GAG>CAG	p.E173Q	MYO1F_uc002mkh.2_Missense_Mutation_p.E173Q|MYO1F_uc010xkf.1_Missense_Mutation_p.E173Q	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	173	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						AACTGGATCTCAAAGTACTTG	0.557													0	0	0	0.058154	0	7	125										G	8617036	C	G	8617036	3	3	60	1	0	0	0	0	1	0	0	0	10073	835	29	1	2867	1	MYO1F	19	8617036	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		8617036	50511947	202	17471										
LDLR	3949	broad.mit.edu	37	chr19	11213402	11213402	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtgtcaaccgctgcattcctCagttctggaggtgcgatggc	13	11	3	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:11213402C>T	uc002mqk.3	+	3	421	c.253C>T	c.(253-255)CAG>TAG	p.Q85*	LDLR_uc010xlk.1_Nonsense_Mutation_p.Q85*|LDLR_uc010xll.1_Intron|LDLR_uc010xlm.1_Intron|LDLR_uc010xln.1_Nonsense_Mutation_p.Q85*|LDLR_uc010xlo.1_Nonsense_Mutation_p.Q85*	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	85	Extracellular (Potential).|LDL-receptor class A 2.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGCATTCCTCAGTTCTGGAG	0.547													0	0	0	0.041601	0	27	125										T	11213402	C	T	11213402	4	4	60	1	0	0	0	0	0	1	0	0	8704	827	29	1	263	1	LDLR	19	11213402	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	2596366	11213402	47915581	203	17472										
ZFP30	22835	broad.mit.edu	37	chr19	38126225	38126225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tacattcataaggtttctctCcaatgtgaataccctgatgt	6	9	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:38126225C>T	uc002ogv.1	-	6	1733	c.1217G>A	c.(1216-1218)GGA>GAA	p.G406E	ZFP30_uc002ogw.1_Missense_Mutation_p.G406E|ZFP30_uc002ogx.1_Missense_Mutation_p.G406E|ZFP30_uc010xtt.1_Missense_Mutation_p.G405E	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	406					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGTTTCTCTCCAATGTGAAT	0.388													0	0	0	0.069234	0	8	47										T	38126225	C	T	38126225	3	4	60	1	0	0	0	0	1	0	0	0	17641	855	30	1	346	1	ZFP30	19	38126225	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	26912823	38126225	21002758	204	17473										
ZNF781	163115	broad.mit.edu	37	chr19	38160986	38160986	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agcatgacttatttgatattGagttagttgaaagttacaag	9	3	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:38160986G>C	uc002ogy.2	-	4	806	c.64C>G	c.(64-66)CAA>GAA	p.Q22E	ZNF781_uc002ogz.2_Missense_Mutation_p.Q17E	NM_152605	NP_689818	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTGATATTGAGTTAGTTGA	0.343													0	0	0	0.043863	0	17	123										C	38160986	G	C	38160986	3	2	60	1	0	0	0	0	1	0	0	0	18151	1299	45	1	923	1	ZNF781	19	38160986	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	34761	38160986	20967997	205	17474										
ZNF233	353355	broad.mit.edu	37	chr19	44778410	44778410	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	atcagagagttcacaaaggaGagaagccatacaaatgtgag	11	6	2	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:44778410G>C	uc002oyz.1	+	5	1724	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.E348Q	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				TCACAAAGGAGAGAAGCCATA	0.468													0	0	0	0.069234	0	8	59										C	44778410	G	C	44778410	3	2	60	1	0	0	0	0	1	0	0	0	17783	943	33	1	1611	1	ZNF233	19	44778410	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6617424	44778410	14350573	206	17475										
ZNF233	353355	broad.mit.edu	37	chr19	44778580	44778580	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cagagagtccacacaggagaGaaaccatacaaatgtgaaga	10	8	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:44778580G>C	uc002oyz.1	+	5	1894	c.1767G>C	c.(1765-1767)GAG>GAC	p.E589D	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.E404D	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				ACACAGGAGAGAAACCATACA	0.438													0	0	0	0.004672	0	3	103										C	44778580	G	C	44778580	3	2	60	1	0	0	0	0	1	0	0	0	17783	933	33	1	1781	1	ZNF233	19	44778580	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	170	44778580	14350403	207	17476										
ZIK1	284307	broad.mit.edu	37	chr19	58101415	58101415	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	agaggatgaagagacaccttCtgaccagaatgtttctgtag	11	7	2	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr19:58101415C>T	uc002qpg.2	+	4	333	c.236C>T	c.(235-237)TCT>TTT	p.S79F	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.S24F|ZIK1_uc002qpi.2_Missense_Mutation_p.S66F|ZIK1_uc002qpj.2_5'UTR	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGACACCTTCTGACCAGAAT	0.458													0	0	0	0.047766	0	8	45										T	58101415	C	T	58101415	3	4	60	1	0	0	0	0	1	0	0	0	17680	913	32	1	250	1	ZIK1	19	58101415	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	13322835	58101415	1027568	208	17477										
TBC1D20	128637	broad.mit.edu	37	chr20	422526	422526	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtggtgggtagataatttttCtaccagggatgttgccagcc	13	7	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:422526C>A	uc002wds.2	-	4	637	c.499G>T	c.(499-501)GAA>TAA	p.E167*	TBC1D20_uc002wdv.2_5'UTR|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	167	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				GATAATTTTTCTACCAGGGAT	0.537													1	0	1.33987e-11	0.069234	1.51487e-11	6	92										A	422526	C	A	422526	4	1	60	1	0	0	0	0	0	1	0	0	15606	922	32	3	732	3	TBC1D20	20	422526	Nonsense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		422526	62602994	209	17478										
SLC4A11	83959	broad.mit.edu	37	chr20	3211823	3211823	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aagtccaaggggtacaagggGaacctgcgtgcgatgtcctc	14	10	0	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:3211823G>T	uc002wig.2	-	8	1110	c.1062C>A	c.(1060-1062)TTC>TTA	p.F354L	SLC4A11_uc010zqe.1_Missense_Mutation_p.F381L|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.F338L	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	354	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						GGTACAAGGGGAACCTGCGTG	0.602													1	0	1.5739e-10	0.028581	1.77223e-10	13	128										T	3211823	G	T	3211823	3	4	60	1	0	0	0	0	1	0	0	0	14652	1165	41	3	1661	3	SLC4A11	20	3211823	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	2789297	3211823	59813697	210	17479										
GGTLC1	92086	broad.mit.edu	37	chr20	23966391	23966391	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acggcccacttcacgtcataGccgaaccagaggttgtagat	10	12	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:23966391G>T	uc002wts.2	-	5	577	c.444C>A	c.(442-444)GGC>GGA	p.G148G	GGTLC1_uc002wtu.2_Silent_p.G148G	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	148							gamma-glutamyltransferase activity			ovary(1)	1						TCACGTCATAGCCGAACCAGA	0.612													1	0	4.45325e-31	0.048971	5.1613e-31	55	129										T	23966391	G	T	23966391	2	4	60	1	0	0	0	0	0	0	0	1	6365	958	34	4		4	GGTLC1	20	23966391	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	20754568	23966391	39059129	211	17480										
TTLL9	164395	broad.mit.edu	37	chr20	30525290	30525290	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcctcctggaagacaccctgCatgttgtggacatggaagcg	13	11	0	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:30525290C>A	uc010gdx.1	+	13	1349	c.1096C>A	c.(1096-1098)CAT>AAT	p.H366N	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_RNA|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Missense_Mutation_p.H268N|TTLL9_uc010ztp.1_RNA|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	366	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGACACCCTGCATGTTGTGGA	0.567													1	0	5.50884e-06	0.09319	5.93754e-06	11	40										A	30525290	C	A	30525290	3	1	60	1	0	0	0	0	1	0	0	0	16731	710	25	4	1142	4	TTLL9	20	30525290	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	6558899	30525290	32500230	212	17481										
MYH7B	57644	broad.mit.edu	37	chr20	33586326	33586326	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcctgcaggggagctgagtcGcctgctagaggagaaggagt	18	8	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:33586326G>C	uc002xbi.1	+	32	4105	c.4013G>C	c.(4012-4014)CGC>CCC	p.R1338P		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1296	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GAGCTGAGTCGCCTGCTAGAG	0.642													0	0	0	0.014758	0	4	43										C	33586326	G	C	33586326	3	2	60	1	0	0	0	0	1	0	0	0	10040	1087	38	4	4139	4	MYH7B	20	33586326	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3061036	33586326	29439194	213	17482										
BPI	671	broad.mit.edu	37	chr20	36959492	36959492	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcaaatattggccccttcccGgtgagtctgaggcccttggt	11	12	2	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:36959492G>A	uc002xib.2	+	12	1346	c.1284G>A	c.(1282-1284)CCG>CCA	p.P428P		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	428					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GCCCCTTCCCGGTGAGTCTGA	0.572													0	0	0	0.047766	0	9	95										A	36959492	G	A	36959492	2	1	60	1	0	0	0	0	0	0	0	1	1490	1130	39	2		2	BPI	20	36959492	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	3373166	36959492	26066028	214	17483										
RALGAPB	57148	broad.mit.edu	37	chr20	37182516	37182516	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ttggtttattacagttagaaGagagacacgaaaaattaagg	10	3	0	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:37182516G>C	uc002xiw.2	+	22	3426	c.3169G>C	c.(3169-3171)GAG>CAG	p.E1057Q	RALGAPB_uc002xix.2_Missense_Mutation_p.E1053Q|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.E835Q	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1057					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						ACAGTTAGAAGAGAGACACGA	0.313													0	0	0	0.038147	0	7	20										C	37182516	G	C	37182516	3	2	60	1	0	0	0	0	1	0	0	0	13015	943	33	1	3251	1	RALGAPB	20	37182516	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	223024	37182516	25843004	215	17484										
RALGAPB	57148	broad.mit.edu	37	chr20	37182716	37182716	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tttttgtccttagaagcactGaaggtaattttcatgaactt	7	6	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:37182716G>A	uc002xiw.2	+	22	3626	c.3369G>A	c.(3367-3369)CTG>CTA	p.L1123L	RALGAPB_uc002xix.2_Silent_p.L1119L|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Silent_p.L901L	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1123					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TAGAAGCACTGAAGGTAATTT	0.383													0	0	0	0.041601	0	25	69										A	37182716	G	A	37182716	2	1	60	1	0	0	0	0	0	0	0	1	13015	1277	45	1		1	RALGAPB	20	37182716	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	200	37182716	25842804	216	17485										
RBPJL	11317	broad.mit.edu	37	chr20	43940280	43940280	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tcggggcctggctggagggtGaagccagggcaggatcaagg	20	8	1	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:43940280G>A	uc002xns.2	+	4	381	c.309G>A	c.(307-309)GTG>GTA	p.V103V	RBPJL_uc002xnt.2_Silent_p.V103V	NM_014276	NP_055091	Q9UBG7	RBPJL_HUMAN	recombining binding protein L	103					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GCTGGAGGGTGAAGCCAGGGC	0.642											OREG0025979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.030593	0	26	37										A	43940280	G	A	43940280	2	1	60	1	0	0	0	0	0	0	0	1	13162	1277	45	1		1	RBPJL	20	43940280	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	6757564	43940280	19085240	217	17486										
ADRM1	11047	broad.mit.edu	37	chr20	60878630	60878630	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctccgcgctttcaggatgacGacctcaggcgcgctctttcc	10	16	3	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr20:60878630G>A	uc002ycn.2	+	2	86	c.6G>A	c.(4-6)ACG>ACA	p.T2T	ADRM1_uc011aai.1_Silent_p.T2T|ADRM1_uc002yco.2_Silent_p.T2T|ADRM1_uc002ycp.1_5'Flank	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	2	Interaction with PSMD1.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			TCAGGATGACGACCTCAGGCG	0.667													0	0	0	0.058154	0	9	108										A	60878630	G	A	60878630	2	1	60	1	0	0	0	0	0	0	0	1	345	1045	37	1		1	ADRM1	20	60878630	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	16938350	60878630	2146890	218	17487										
TIAM1	7074	broad.mit.edu	37	chr21	32617837	32617837	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gcatcacccagggaattgctGaggcagaagacaaagtcctt	11	10	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr21:32617837G>A	uc002yow.1	-	7	2023	c.1551C>T	c.(1549-1551)CTC>CTT	p.L517L	TIAM1_uc011adk.1_Silent_p.L517L|TIAM1_uc011adl.1_Silent_p.L517L|TIAM1_uc002yox.1_Silent_p.L125L	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	517	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GGGAATTGCTGAGGCAGAAGA	0.522													0	0	0	0.09319	0	11	32										A	32617837	G	A	32617837	2	1	60	1	0	0	0	0	0	0	0	1	15887	1277	45	1		1	TIAM1	21	32617837	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		32617837	15512058	219	17488										
COL18A1	80781	broad.mit.edu	37	chr21	46913126	46913126	+	Frame_Shift_Del	DEL	C	C	-													0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctctaagggcgaacgaggctCcccgggacccaaggtaaggg							TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr21:46913126delC	uc011afs.1	+	24	3530	c.3509delC	c.(3508-3510)TCCfs	p.S1170fs	COL18A1_uc002zhg.2_Frame_Shift_Del_p.S755fs|COL18A1_uc002zhi.2_Frame_Shift_Del_p.S935fs	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1170	Triple-helical region 5 (COL5).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GAACGAGGCTCCCCGGGACCC	0.672																		2	4	---	---								-	46913126	C	-	46913126	7	5	60	1	0	1	0	1	0	0	0	0	3675	855	30	0	3717	0	COL18A1	21	46913126	Frame_Shift_Del	DEL	C	TCGA-DK-A3IQ-01A-31D-A20D-08	14295289	46913126	1216769	220	17489										
PCNT	5116	broad.mit.edu	37	chr21	47850003	47850003	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	acgctgagtgaagagcaagaGaaggcaaacagcgtgcagaa	14	7	0	5			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr21:47850003G>A	uc002zji.3	+	36	7877	c.7770G>A	c.(7768-7770)GAG>GAA	p.E2590E	PCNT_uc002zjj.2_Silent_p.E2472E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2590	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AAGAGCAAGAGAAGGCAAACA	0.512													0	0	0	0.09319	0	11	37										A	47850003	G	A	47850003	2	1	60	1	0	0	0	0	0	0	0	1	11590	933	33	1		1	PCNT	21	47850003	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	936877	47850003	279892	221	17490			2	72		3	3	1758	G		8.51509e-05
PCNT	5116	broad.mit.edu	37	chr21	47851509	47851509	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tctgcgtggcactgaaacacGagcagacggccaaggacaac	12	12	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr21:47851509G>A	uc002zji.3	+	38	8238	c.8131G>A	c.(8131-8133)GAG>AAG	p.E2711K	PCNT_uc002zjj.2_Missense_Mutation_p.E2593K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2711	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					ACTGAAACACGAGCAGACGGC	0.597													0	0	0	0.09319	0	12	55										A	47851509	G	A	47851509	3	1	60	1	0	0	0	0	1	0	0	0	11590	1059	37	1	8281	1	PCNT	21	47851509	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	1506	47851509	278386	222	17491			2	72		3	3	1758	G		8.51509e-05
PCNT	5116	broad.mit.edu	37	chr21	47851760	47851760	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cacgctctgctgcagaagctGaaggaggagaagtcccgggt	15	10	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr21:47851760G>A	uc002zji.3	+	38	8489	c.8382G>A	c.(8380-8382)CTG>CTA	p.L2794L	PCNT_uc002zjj.2_Silent_p.L2676L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2794	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGCAGAAGCTGAAGGAGGAGA	0.612													0	0	0	0.069234	0	7	35										A	47851760	G	A	47851760	2	1	60	1	0	0	0	0	0	0	0	1	11590	1277	45	1		1	PCNT	21	47851760	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	251	47851760	278135	223	17492			2	72		3	3	1758	G		8.51509e-05
SLC25A1	6576	broad.mit.edu	37	chr22	19164697	19164697	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tacttggggtttggggaggtCtggtcgtggatgaacttcac	16	6	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr22:19164697C>G	uc002zoz.2	-	5	577	c.462G>C	c.(460-462)CAG>CAC	p.Q154H	SLC25A1_uc002zoy.2_Missense_Mutation_p.Q51H|SLC25A1_uc002zpa.2_Missense_Mutation_p.Q102H	NM_005984	NP_005975	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier;	154	Solcar 2.				gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding				0	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		TTGGGGAGGTCTGGTCGTGGA	0.602													0	0	0	0.105934	0	12	33										G	19164697	C	G	19164697	3	3	60	1	0	0	0	0	1	0	0	0	14471	912	32	1	493	1	SLC25A1	22	19164697	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08		19164697	32139869	224	17493										
MTMR3	8897	broad.mit.edu	37	chr22	30403279	30403279	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cacttctcgagactttcccaAtgggggagacctttctgacg	10	12	2	3	rs138787389	byFrequency	TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr22:30403279A>G	uc003agv.3	+	10	1176	c.848A>G	c.(847-849)AAT>AGT	p.N283S	MTMR3_uc003agu.3_Missense_Mutation_p.N283S|MTMR3_uc003agw.3_Missense_Mutation_p.N283S	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	283	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			GACTTTCCCAATGGGGGAGAC	0.493													0	0	0	0.105934	0	10	42										G	30403279	A	G	30403279	3	3	60	1	0	0	0	0	1	0	0	0	9945	101	4	5	878	5	MTMR3	22	30403279	Missense_Mutation	SNP	A	TCGA-DK-A3IQ-01A-31D-A20D-08	11238582	30403279	20901287	225	17494										
OSM	5008	broad.mit.edu	37	chr22	30659990	30659990	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tccggctccggttcgggctcTccccccacttgctgaagacc	10	18	1	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr22:30659990T>C	uc003ahb.2	-	3	693	c.641A>G	c.(640-642)GAG>GGG	p.E214G		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	214					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			GTTCGGGCTCTCCCCCCACTT	0.642													0	0	0	0.009096	0	4	66										C	30659990	T	C	30659990	3	2	60	1	0	0	0	0	1	0	0	0	11291	1551	54	5	121	5	OSM	22	30659990	Missense_Mutation	SNP	T	TCGA-DK-A3IQ-01A-31D-A20D-08	256711	30659990	20644576	226	17495										
BRD1	23774	broad.mit.edu	37	chr22	50192221	50192221	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	cccacctccttcagactcacGggctgcgcaaatatcctggc	8	17	2	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chr22:50192221G>A	uc003biv.2	-	4	2257	c.1770C>T	c.(1768-1770)CCC>CCT	p.P590P	BRD1_uc011arf.1_Silent_p.P185P|BRD1_uc011arg.1_Silent_p.P644P|BRD1_uc011arh.1_Silent_p.P590P|BRD1_uc003biu.3_Silent_p.P590P	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	590	Bromo.				histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCAGACTCACGGGCTGCGCAA	0.622													0	0	0	0.0333	0	14	70										A	50192221	G	A	50192221	2	1	60	1	0	0	0	0	0	0	0	1	1501	1103	39	2		2	BRD1	22	50192221	Silent	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	19532231	50192221	1112345	227	17496										
CNKSR2	22866	broad.mit.edu	37	chrX	21613156	21613156	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tgatagagccagtgaatgccGcaaaaaatagtaagttgatt	10	5	0	4			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chrX:21613156G>A	uc004czx.1	+	16	1931	c.1895G>A	c.(1894-1896)CGC>CAC	p.R632H	CNKSR2_uc004czw.2_Missense_Mutation_p.R632H|CNKSR2_uc011mjn.1_Missense_Mutation_p.R583H|CNKSR2_uc011mjo.1_Missense_Mutation_p.R602H|CNKSR2_uc004czy.2_Missense_Mutation_p.R224H	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	632	PH.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AGTGAATGCCGCAAAAAATAG	0.323													0	0	0	0.058154	0	8	9										A	21613156	G	A	21613156	3	1	60	1	0	0	0	0	1	0	0	0	3607	1087	38	2	1957	2	CNKSR2	23	21613156	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08		21613156	133657404	228	17497										
RPGR	6103	broad.mit.edu	37	chrX	38156638	38156638	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	aattggggagaaaacaagcaGaaaggccaagagtcccttct	11	8	1	3			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chrX:38156638G>C	uc004ded.1	-	11	1481	c.1313C>G	c.(1312-1314)TCT>TGT	p.S438C	RPGR_uc004deb.2_Missense_Mutation_p.S438C|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA|RPGR_uc004dee.1_Missense_Mutation_p.S123C	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	438					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						AAAACAAGCAGAAAGGCCAAG	0.428													0	0	0	0.069234	0	10	20										C	38156638	G	C	38156638	3	2	60	1	0	0	0	0	1	0	0	0	13548	942	33	1	2724	1	RPGR	23	38156638	Missense_Mutation	SNP	G	TCGA-DK-A3IQ-01A-31D-A20D-08	16543482	38156638	117113922	229	17498										
WDR45	11152	broad.mit.edu	37	chrX	48933234	48933234	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	tggcagggtcagtgcctcggCgcagctccaccagtttctcc	12	15	2	0			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chrX:48933234C>A	uc004dmk.1	-	8	867	c.695G>T	c.(694-696)CGC>CTC	p.R232L	PRAF2_uc004dmh.2_5'Flank|PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Missense_Mutation_p.R130L|WDR45_uc004dmj.1_Missense_Mutation_p.R193L|WDR45_uc004dml.1_Missense_Mutation_p.R233L|WDR45_uc004dmm.1_Missense_Mutation_p.R197L|WDR45_uc010nim.1_Missense_Mutation_p.R232L|WDR45_uc004dmn.1_Missense_Mutation_p.R123L|WDR45_uc004dmo.1_Missense_Mutation_p.R255L|WDR45_uc004dmp.1_Missense_Mutation_p.R233L	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	232					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						AGTGCCTCGGCGCAGCTCCAC	0.567													1	0	0.00448238	0.047766	0.00459859	7	17										A	48933234	C	A	48933234	3	1	60	1	0	0	0	0	1	0	0	0	17294	768	27	4	403	4	WDR45	23	48933234	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	10776596	48933234	106337326	230	17499										
PJA1	64219	broad.mit.edu	37	chrX	68381656	68381656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ctcgtgaccagaatcattatCcccctcactgctactgtcat	5	15	3	2			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chrX:68381656C>T	uc004dxh.2	-	2	1712	c.1426G>A	c.(1426-1428)GAT>AAT	p.D476N	PJA1_uc011mpi.1_Missense_Mutation_p.D194N|PJA1_uc004dxg.2_Missense_Mutation_p.D288N|PJA1_uc004dxi.2_Missense_Mutation_p.D421N	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	476							zinc ion binding				0						GAATCATTATCCCCCTCACTG	0.478													0	0	0	0.021553	0	4	115										T	68381656	C	T	68381656	3	4	60	1	0	0	0	0	1	0	0	0	11961	855	30	1	509	1	PJA1	23	68381656	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	19448422	68381656	86888904	231	17500										
GLA	2717	broad.mit.edu	37	chrX	100656704	100656704	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	gtcagcaaaggtctgggcatCaatgtcgtagtatccaaaac	10	9	3	0	rs113419388		TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chrX:100656704C>G	uc004ehl.1	-	3	573	c.463G>C	c.(463-465)GAT>CAT	p.D155H	GLA_uc011mrj.1_Missense_Mutation_p.D155H	NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	155					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	GTCTGGGCATCAATGTCGTAG	0.428													0	0	0	0.059317	0	29	42										G	100656704	C	G	100656704	3	3	60	1	0	0	0	0	1	0	0	0	6426	826	29	1	846	1	GLA	23	100656704	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	32275048	100656704	54613856	232	17501										
USP26	83844	broad.mit.edu	37	chrX	132162154	132162154	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.45021645021645	104	6.03111960324932e-39	3.9602081823572	4.82600268376323	3.53107525557335	0.0122608619812848	0.0393758449526939	78	ccagtctatctttcttctttCtttccactgcttcaatgaat	3	12	6	1			TCGA-DK-A3IQ-01A-31D-A20D-08	TCGA-DK-A3IQ-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3da3cc2-2299-4a3e-9de8-7a1d0a10345d	a35775c2-b069-4eb4-8b54-631a4d99907d	g.chrX:132162154C>A	uc010nrm.1	-	6	565	c.95G>T	c.(94-96)AGA>ATA	p.R32I	USP26_uc011mvf.1_Missense_Mutation_p.R32I	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	32					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					TTTCTTCTTTCTTTCCACTGC	0.368													1	0	0.00116845	0.021553	0.00121221	6	17										A	132162154	C	A	132162154	3	1	60	1	0	0	0	0	1	0	0	0	17054	913	32	3	2649	3	USP26	23	132162154	Missense_Mutation	SNP	C	TCGA-DK-A3IQ-01A-31D-A20D-08	31505450	132162154	23108406	233	17502										
HES4	57801	broad.mit.edu	37	chr1	934921	934921	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctcacccgtcacctgcacgcGacgcaggctccgcaggtgtc	11	18	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:934921G>A	uc001aci.2	-	3	476	c.277C>T	c.(277-279)CGC>TGC	p.R93C	HES4_uc010nyc.1_Missense_Mutation_p.R119C	NM_021170	NP_066993	Q9HCC6	HES4_HUMAN	hairy and enhancer of split 4 isoform 2	93					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;9.36e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.41e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00237)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACCTGCACGCGACGCAGGCTC	0.736													0	0	0	0.004672	0	3	10										A	934921	G	A	934921	3	1	61	1	0	0	0	0	1	0	0	0	7068	1058	37	1	396	1	HES4	1	934921	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		934921	248315700	1	17503										
SPEN	23013	broad.mit.edu	37	chr1	16261448	16261448	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgatttcgtctgtgaaggccGataggccatccttggagaag	13	8	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:16261448G>A	uc001axk.1	+	11	8917	c.8713G>A	c.(8713-8715)GAT>AAT	p.D2905N	SPEN_uc010obp.1_Missense_Mutation_p.D2864N	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2905					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGTGAAGGCCGATAGGCCATC	0.577													0	0	0	0.014323	0	18	19										A	16261448	G	A	16261448	3	1	61	1	0	0	0	0	1	0	0	0	15037	1058	37	1	8755	1	SPEN	1	16261448	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	15326527	16261448	232989173	2	17504										
KIAA0090	23065	broad.mit.edu	37	chr1	19557916	19557916	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagagaactcattcccgactCctaaaatgagcaaactgtca	6	12	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:19557916C>G	uc001bbo.2	-	16	1826	c.1783G>C	c.(1783-1785)GAG>CAG	p.E595Q	KIAA0090_uc001bbp.2_Missense_Mutation_p.E594Q|KIAA0090_uc001bbq.2_Missense_Mutation_p.E594Q|KIAA0090_uc001bbr.2_Missense_Mutation_p.E573Q	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	595	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		ATTCCCGACTCCTAAAATGAG	0.507													0	0	0	0.001168	0	5	13										G	19557916	C	G	19557916	3	3	61	1	0	0	0	0	1	0	0	0	8153	869	30	1	1230	1	KIAA0090	1	19557916	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3296468	19557916	229692705	3	17505										
TMEM50A	23585	broad.mit.edu	37	chr1	25678151	25678151	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgaatggacaagtccgaggtGatagttacagtgaaggttgt	14	5	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:25678151G>T	uc001bke.2	+	4	391	c.241G>T	c.(241-243)GAT>TAT	p.D81Y	TMEM50A_uc010oeq.1_Missense_Mutation_p.D81Y|TMEM50A_uc009vrr.2_RNA|TMEM50A_uc009vrs.2_RNA	NM_014313	NP_055128	O95807	TM50A_HUMAN	small membrane protein 1	81						endoplasmic reticulum|integral to membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)		AGTCCGAGGTGATAGTTACAG	0.358													1	0	1.20466e-24	0.01441	1.30241e-24	44	46										T	25678151	G	T	25678151	3	4	61	1	0	0	0	0	1	0	0	0	16172	1290	45	3	251	3	TMEM50A	1	25678151	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6120235	25678151	223572470	4	17506										
PTAFR	5724	broad.mit.edu	37	chr1	28476921	28476921	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cggatgatgaccaggttgcaGaagaggatgatgaggaagac	16	5	0	7			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:28476921G>T	uc001bpl.2	-	2	739	c.612C>A	c.(610-612)TTC>TTA	p.F204L	PTAFR_uc001bpm.3_Missense_Mutation_p.F204L|PTAFR_uc009vte.2_Missense_Mutation_p.F204L	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	204	Helical; Name=5; (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGTTGCAGAAGAGGATGA	0.567													1	0	2.32078e-09	0.003163	2.42404e-09	15	13										T	28476921	G	T	28476921	3	4	61	1	0	0	0	0	1	0	0	0	12723	933	33	3	420	3	PTAFR	1	28476921	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2798770	28476921	220773700	5	17507										
PTAFR	5724	broad.mit.edu	37	chr1	28477482	28477482	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atgctgtaaacaatcgggaaGagagtgtatcggaactcaga	12	6	1	2	rs143590918		TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:28477482G>C	uc001bpl.2	-	2	178	c.51C>G	c.(49-51)CTC>CTG	p.L17L	PTAFR_uc001bpm.3_Silent_p.L17L|PTAFR_uc009vte.2_Silent_p.L17L	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	17	Helical; Name=1; (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CAATCGGGAAGAGAGTGTATC	0.527													0	0	0	0.007835	0	30	29										C	28477482	G	C	28477482	2	2	61	1	0	0	0	0	0	0	0	1	12723	929	33	1		1	PTAFR	1	28477482	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	561	28477482	220773139	6	17508										
ZMYM4	9202	broad.mit.edu	37	chr1	35851047	35851047	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttattctcttaatagaaatCagccaaaattacaccgtgtg	5	8	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:35851047C>G	uc001byt.2	+	10	1654	c.1574C>G	c.(1573-1575)TCA>TGA	p.S525*	ZMYM4_uc009vuu.2_Nonsense_Mutation_p.S493*|ZMYM4_uc001byu.2_Nonsense_Mutation_p.S201*|ZMYM4_uc009vuv.2_Nonsense_Mutation_p.S264*	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	525	MYM-type 4.				multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TAATAGAAATCAGCCAAAATT	0.318													0	0	0	0.009718	0	29	50										G	35851047	C	G	35851047	4	3	61	1	0	0	0	0	0	1	0	0	17699	838	29	1	1612	1	ZMYM4	1	35851047	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	7373565	35851047	213399574	7	17509										
FAM176B	55194	broad.mit.edu	37	chr1	36788636	36788636	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atgtcccttcgcggggcatcCatgctgctctggggggcagc	15	13	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:36788636C>T	uc001cai.1	-	1	214	c.3G>A	c.(1-3)ATG>ATA	p.M1I	C1orf113_uc010oic.1_Intron|FAM176B_uc001caj.1_Missense_Mutation_p.M1I	NM_018166	NP_060636	Q9NVM1	F176B_HUMAN	hypothetical protein LOC55194	1						integral to membrane				pancreas(1)	1						GCGGGGCATCCATGCTGCTCT	0.687													0	0	0	0.013114	0	37	44										T	36788636	C	T	36788636	3	4	61	1	0	0	0	0	1	0	0	0	5500	594	21	2	502	2	FAM176B	1	36788636	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	937589	36788636	212461985	8	17510										
HIVEP3	59269	broad.mit.edu	37	chr1	42041338	42041338	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatctttctggccttccgggGaaaccagtgaagggaggtga	15	8	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:42041338G>A	uc001cgz.3	-	5	6297	c.5084C>T	c.(5083-5085)TCC>TTC	p.S1695F	HIVEP3_uc001cha.3_Missense_Mutation_p.S1695F|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1695					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCCTTCCGGGGAAACCAGTGA	0.542													0	0	0	0.013114	0	39	37										A	42041338	G	A	42041338	3	1	61	1	0	0	0	0	1	0	0	0	7188	1174	41	1	2156	1	HIVEP3	1	42041338	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5252702	42041338	207209283	9	17511										
NASP	4678	broad.mit.edu	37	chr1	46083736	46083736	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttctgtttgtcttccaggctGagaatcaggctgaaagccgg	12	9	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:46083736G>A	uc001coi.1	+	15	2392	c.2290G>A	c.(2290-2292)GAG>AAG	p.E764K	NASP_uc001coh.1_Missense_Mutation_p.E766K|NASP_uc001coj.1_Missense_Mutation_p.E425K|NASP_uc010olr.1_Missense_Mutation_p.E700K|NASP_uc001col.1_Missense_Mutation_p.E272K	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	764	Potential.				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					CTTCCAGGCTGAGAATCAGGC	0.517													0	0	0	0.00308	0	5	7										A	46083736	G	A	46083736	3	1	61	1	0	0	0	0	1	0	0	0	10172	1291	45	1	2425	1	NASP	1	46083736	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4042398	46083736	203166885	10	17512										
RNF11	26994	broad.mit.edu	37	chr1	51736896	51736896	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgtgcatgcacatctatcacCtggactgtatagatgactgg	10	10	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:51736896C>T	uc001csi.3	+	3	851	c.367C>T	c.(367-369)CTG>TTG	p.L123L		NM_014372	NP_055187	Q9Y3C5	RNF11_HUMAN	ring finger protein 11	123	RING-type.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	DNA binding|protein binding|zinc ion binding				0						CATCTATCACCTGGACTGTAT	0.473													0	0	0	0.013726	0	27	168										T	51736896	C	T	51736896	2	4	61	1	0	0	0	0	0	0	0	1	13424	680	24	2		2	RNF11	1	51736896	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5653160	51736896	197513725	11	17513										
ACOT11	26027	broad.mit.edu	37	chr1	55058277	55058277	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gggccttcaactccagcatgGaggtgtgtggggtgggcact	17	9	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:55058277G>C	uc001cxm.1	+	4	452	c.370G>C	c.(370-372)GAG>CAG	p.E124Q	ACOT11_uc001cxj.1_Missense_Mutation_p.E2Q|ACOT11_uc001cxk.2_Missense_Mutation_p.E90Q|ACOT11_uc001cxl.1_Missense_Mutation_p.E124Q	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	124	Acyl coenzyme A hydrolase 1.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CTCCAGCATGGAGGTGTGTGG	0.597													0	0	0	0.006999	0	35	49										C	55058277	G	C	55058277	3	2	61	1	0	0	0	0	1	0	0	0	149	1175	41	1	384	1	ACOT11	1	55058277	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3321381	55058277	194192344	12	17514										
FGGY	55277	broad.mit.edu	37	chr1	60139745	60139745	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgtcgcaagaggtggagtcCgttcttgtgggtgctgctgt	16	8	1	1	rs114601020	by1000genomes	TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:60139745C>G	uc001czi.3	+	14	1664	c.1452C>G	c.(1450-1452)TCC>TCG	p.S484S	FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Silent_p.S508S|FGGY_uc001czj.3_Silent_p.S483S|FGGY_uc001czk.3_Silent_p.S372S|FGGY_uc001czl.3_Silent_p.S396S|FGGY_uc001czm.3_Silent_p.S185S	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	484					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					AGGTGGAGTCCGTTCTTGTGG	0.612													0	0	0	0.010504	0	15	28										G	60139745	C	G	60139745	2	3	61	1	0	0	0	0	0	0	0	1	5871	639	23	4		4	FGGY	1	60139745	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5081468	60139745	189110876	13	17515										
C1orf173	127254	broad.mit.edu	37	chr1	75037663	75037663	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aggagtcgtgatctttggctGctagctcctctgcctggcct	12	12	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:75037663G>T	uc001dgg.2	-	14	3950	c.3731C>A	c.(3730-3732)GCA>GAA	p.A1244E		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1244	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ATCTTTGGCTGCTAGCTCCTC	0.617													1	0	1.01871e-10	0.008871	1.0663e-10	15	40										T	75037663	G	T	75037663	3	4	61	1	0	0	0	0	1	0	0	0	2014	1319	46	4	865	4	C1orf173	1	75037663	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14897918	75037663	174212958	14	17516										
HFM1	164045	broad.mit.edu	37	chr1	91778938	91778938	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgctattgtagatatgtctGaatgtttagaatgggaaatc	10	4	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:91778938G>A	uc001doa.3	-	30	3459	c.3359C>T	c.(3358-3360)TCA>TTA	p.S1120L	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.S799L|HFM1_uc001dob.3_Missense_Mutation_p.S308L|HFM1_uc010osv.1_Missense_Mutation_p.S804L	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1120							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AGATATGTCTGAATGTTTAGA	0.328													0	0	0	0.001168	0	4	74										A	91778938	G	A	91778938	3	1	61	1	0	0	0	0	1	0	0	0	7083	1294	45	1	988	1	HFM1	1	91778938	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	16741275	91778938	157471683	15	17517										
FNDC7	163479	broad.mit.edu	37	chr1	109271379	109271379	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaggggagaaaggactgtatCagtgcagcagcacaggagag	16	6	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:109271379C>T	uc001dvx.2	+	8	1495	c.1495C>T	c.(1495-1497)CAG>TAG	p.Q499*	FNDC7_uc010ova.1_Nonsense_Mutation_p.Q266*	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	500	Fibronectin type-III 6.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AGGACTGTATCAGTGCAGCAG	0.542													0	0	0	0.005524	0	30	40										T	109271379	C	T	109271379	4	4	61	1	0	0	0	0	0	1	0	0	5973	827	29	1	1525	1	FNDC7	1	109271379	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	17492441	109271379	139979242	16	17518										
IGSF3	3321	broad.mit.edu	37	chr1	117150798	117150798	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaggacaggcacagcgttagGacccatggtggcgatgagcg	17	9	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:117150798G>A	uc001egr.1	-	5	1693	c.988C>T	c.(988-990)CCT>TCT	p.P330S	IGSF3_uc001egq.1_Missense_Mutation_p.P330S|IGSF3_uc001egs.1_Missense_Mutation_p.P3S	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	330	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ACAGCGTTAGGACCCATGGTG	0.562													0	0	0	0.00245	0	11	13										A	117150798	G	A	117150798	3	1	61	1	0	0	0	0	1	0	0	0	7601	1174	41	1	2688	1	IGSF3	1	117150798	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7879419	117150798	132099823	17	17519										
CD101	9398	broad.mit.edu	37	chr1	117556174	117556174	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggactgaaattgctcacattGatgctggtggagtcctgggc	14	8	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:117556174G>A	uc010oxb.1	+	4	1046	c.988G>A	c.(988-990)GAT>AAT	p.D330N	CD101_uc009whd.2_Missense_Mutation_p.D330N|CD101_uc010oxc.1_Missense_Mutation_p.D330N|CD101_uc010oxd.1_Missense_Mutation_p.D268N	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	330	Ig-like C2-type 3.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TGCTCACATTGATGCTGGTGG	0.493													0	0	0	0.008291	0	8	73										A	117556174	G	A	117556174	3	1	61	1	0	0	0	0	1	0	0	0	2962	1290	45	1	1002	1	CD101	1	117556174	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	405376	117556174	131694447	18	17520										
ANKRD34A	284615	broad.mit.edu	37	chr1	145473612	145473612	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgggggcgccgcggtggcctCgctgctccttgcccacggcg	17	16	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:145473612C>T	uc001enq.1	+	4	1577	c.284C>T	c.(283-285)TCG>TTG	p.S95L	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	95	ANK 3.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCGGTGGCCTCGCTGCTCCTT	0.721													0	0	0	0.009535	0	29	16										T	145473612	C	T	145473612	3	4	61	1	0	0	0	0	1	0	0	0	662	893	31	1	286	1	ANKRD34A	1	145473612	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	27917438	145473612	103777009	19	17521										
ZNF687	57592	broad.mit.edu	37	chr1	151261980	151261980	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcccgtcttgtcctctgctCtttgcccaaaaaaggaccat	7	14	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:151261980C>G	uc001exq.2	+	5	2696	c.2598C>G	c.(2596-2598)CTC>CTG	p.L866L	ZNF687_uc009wmo.2_Silent_p.L866L|ZNF687_uc009wmp.2_Silent_p.L866L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	866	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTCCTCTGCTCTTTGCCCAAA	0.547													0	0	0	0.004878	0	33	70										G	151261980	C	G	151261980	2	3	61	1	0	0	0	0	0	0	0	1	18089	900	32	1		1	ZNF687	1	151261980	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5788368	151261980	97988641	20	17522										
HRNR	388697	broad.mit.edu	37	chr1	152187697	152187697	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gactgtcctgatctagagccGtgttgtccgtagccagagga	13	10	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:152187697G>A	uc001ezt.1	-	3	6484	c.6408C>T	c.(6406-6408)CAC>CAT	p.H2136H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2136					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCTAGAGCCGTGTTGTCCGT	0.557													0	0	0	0.01441	0	62	546										A	152187697	G	A	152187697	2	1	61	1	0	0	0	0	0	0	0	1	7359	1136	40	2		2	HRNR	1	152187697	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	925717	152187697	97062924	21	17523										
ARHGEF2	9181	broad.mit.edu	37	chr1	155921970	155921970	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caagggcagggctggctctcGgggtgtcaagagcagttcca	16	10	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:155921970G>A	uc001fmt.2	-	16	2159	c.2041C>T	c.(2041-2043)CGA>TGA	p.R681*	ARHGEF2_uc001fmq.2_5'Flank|ARHGEF2_uc001fmr.2_Nonsense_Mutation_p.R653*|ARHGEF2_uc001fms.2_Nonsense_Mutation_p.R680*|ARHGEF2_uc001fmu.2_Nonsense_Mutation_p.R725*	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	681					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding	p.N681S(1)		ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GCTGGCTCTCGGGGTGTCAAG	0.602													0	0	0	0.004482	0	8	63										A	155921970	G	A	155921970	4	1	61	1	0	0	0	0	0	1	0	0	903	1124	39	2	947	2	ARHGEF2	1	155921970	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3734273	155921970	93328651	22	17524										
KCNJ10	3766	broad.mit.edu	37	chr1	160012277	160012277	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcccattaggggccggctttCtgtctgagtggtctgactgt	14	10	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:160012277C>G	uc001fuw.1	-	2	196	c.46G>C	c.(46-48)GAA>CAA	p.E16Q		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	16	Cytoplasmic (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGCCGGCTTTCTGTCTGAGTG	0.532													0	0	0	0.01441	0	142	30										G	160012277	C	G	160012277	3	3	61	1	0	0	0	0	1	0	0	0	8044	922	32	1	1097	1	KCNJ10	1	160012277	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4090307	160012277	89238344	23	17525										
NCSTN	23385	broad.mit.edu	37	chr1	160322686	160322686	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccatctctcaggaaacttttGactacattggcagctcgagg	9	11	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:160322686G>A	uc001fvx.2	+	9	1130	c.1006G>A	c.(1006-1008)GAC>AAC	p.D336N	NCSTN_uc001fvy.2_Missense_Mutation_p.D316N|NCSTN_uc010pjf.1_Missense_Mutation_p.D198N|NCSTN_uc001fvz.2_Missense_Mutation_p.D116N|NCSTN_uc010pjg.1_Missense_Mutation_p.D78N	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	336	Extracellular (Potential).			DY->AA: Increases production of amyloid beta (beta-APP40 and beta-APP42) in APP processing.	amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGAAACTTTTGACTACATTGG	0.502													0	0	0	0.00632	0	22	132										A	160322686	G	A	160322686	3	1	61	1	0	0	0	0	1	0	0	0	10241	1290	45	1	1040	1	NCSTN	1	160322686	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	310409	160322686	88927935	24	17526										
DDR2	4921	broad.mit.edu	37	chr1	162745932	162745932	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtctatttcctcagttacacCaatctgaagtttatggctac	6	10	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:162745932C>G	uc001gcf.2	+	17	2520	c.2055C>G	c.(2053-2055)ACC>ACG	p.T685T	DDR2_uc001gcg.2_Silent_p.T685T	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	685	Cytoplasmic (Potential).|Protein kinase.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCAGTTACACCAATCTGAAGT	0.413													0	0	0	0.01441	0	231	61										G	162745932	C	G	162745932	2	3	61	1	0	0	0	0	0	0	0	1	4337	581	21	4		4	DDR2	1	162745932	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2423246	162745932	86504689	25	17527										
ZBTB41	360023	broad.mit.edu	37	chr1	197169253	197169253	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcagtgcttggatttttgctCaaacacgcatgaaaataact	7	8	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:197169253C>G	uc001gtx.1	-	1	420	c.351G>C	c.(349-351)TTG>TTC	p.L117F	ZBTB41_uc009wyz.1_RNA|CRB1_uc010poz.1_5'Flank	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	117	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						GATTTTTGCTCAAACACGCAT	0.358													0	0	0	0.01441	0	60	26										G	197169253	C	G	197169253	3	3	61	1	0	0	0	0	1	0	0	0	17540	825	29	1	2418	1	ZBTB41	1	197169253	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	34423321	197169253	52081368	26	17528										
PCNXL2	80003	broad.mit.edu	37	chr1	233136233	233136233	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctcgaaggactggatggcctCgtagaggactgctgggtctt	15	9	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:233136233C>T	uc001hvl.2	-	30	5381	c.5146G>A	c.(5146-5148)GAG>AAG	p.E1716K	PCNXL2_uc001hvk.1_Missense_Mutation_p.E368K|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1716						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TGGATGGCCTCGTAGAGGACT	0.612													0	0	0	0.00308	0	7	7										T	233136233	C	T	233136233	3	4	61	1	0	0	0	0	1	0	0	0	11592	893	31	1	1287	1	PCNXL2	1	233136233	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	35966980	233136233	16114388	27	17529										
RYR2	6262	broad.mit.edu	37	chr1	237806719	237806719	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttggtgggcgttatcagcatCgcttttcagatgccaacaat	10	9	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:237806719C>T	uc001hyl.1	+	48	7434	c.7314C>T	c.(7312-7314)ATC>ATT	p.I2438I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2438	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTATCAGCATCGCTTTTCAGA	0.438													0	0	0	0.011902	0	42	34										T	237806719	C	T	237806719	2	4	61	1	0	0	0	0	0	0	0	1	13769	874	31	1		1	RYR2	1	237806719	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4670486	237806719	11443902	28	17530										
RYR2	6262	broad.mit.edu	37	chr1	237947553	237947553	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttgacgtggtcaacgaaggcGgagagaaagagaagatggaa	16	4	1	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr1:237947553G>A	uc001hyl.1	+	90	12661	c.12541G>A	c.(12541-12543)GGA>AGA	p.G4181R	RYR2_uc010pya.1_Missense_Mutation_p.G596R	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4181					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAACGAAGGCGGAGAGAAAGA	0.502													0	0	0	0.00308	0	6	76										A	237947553	G	A	237947553	3	1	61	1	0	0	0	0	1	0	0	0	13769	1117	39	2	12899	2	RYR2	1	237947553	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	140834	237947553	11303068	29	17531										
LAPTM4A	9741	broad.mit.edu	37	chr2	20240714	20240714	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	actgaatgttgacagctggcAtggagtttggatgagtcact	13	6	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:20240714A>T	uc002rdm.2	-	2	678	c.170T>A	c.(169-171)ATG>AAG	p.M57K	LAPTM4A_uc002rdn.2_Missense_Mutation_p.M15K|LAPTM4A_uc010yjx.1_Missense_Mutation_p.M57K	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	57					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACAGCTGGCATGGAGTTTGG	0.373													0	0	0	0.008291	0	8	134										T	20240714	A	T	20240714	3	4	61	1	0	0	0	0	1	0	0	0	8624	217	8	5	555	5	LAPTM4A	2	20240714	Missense_Mutation	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08		20240714	222958659	30	17532										
ADCY3	109	broad.mit.edu	37	chr2	25044461	25044461	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cttcatggccagcgcgaagtCggccaggtcagccaggtgct	14	13	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:25044461C>T	uc002rfs.3	-	19	3251	c.3052G>A	c.(3052-3054)GAC>AAC	p.D1018N	ADCY3_uc002rfr.3_Missense_Mutation_p.D605N|ADCY3_uc010ykm.1_Missense_Mutation_p.D1019N	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	1018	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					AGCGCGAAGTCGGCCAGGTCA	0.612													0	0	0	0.01441	0	60	192										T	25044461	C	T	25044461	3	4	61	1	0	0	0	0	1	0	0	0	295	884	31	1	394	1	ADCY3	2	25044461	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4803747	25044461	218154912	31	17533										
CAD	790	broad.mit.edu	37	chr2	27465812	27465812	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgactcgaatccagaaggaaCgatttggctctacccaggag	11	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:27465812C>T	uc002rji.2	+	42	6613	c.6451C>T	c.(6451-6453)CGA>TGA	p.R2151*	CAD_uc010eyw.2_Nonsense_Mutation_p.R2088*	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	2151	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CCAGAAGGAACGATTTGGCTC	0.552													0	0	0	0.010504	0	14	42										T	27465812	C	T	27465812	4	4	61	1	0	0	0	0	0	1	0	0	2565	528	19	2	6617	2	CAD	2	27465812	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2421351	27465812	215733561	32	17534										
GPN1	11321	broad.mit.edu	37	chr2	27858051	27858051	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atctatgtaatggacacatcGagaagtaccaacccagtgac	8	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:27858051G>A	uc010ymc.1	+	7	537	c.516G>A	c.(514-516)TCG>TCA	p.S172S	ZNF512_uc010yly.1_RNA|GPN1_uc010ezf.2_Silent_p.S146S|GPN1_uc010yma.1_Silent_p.S79S|GPN1_uc010ymb.1_Silent_p.S63S|GPN1_uc010ymd.1_Silent_p.S53S|GPN1_uc010yme.1_Silent_p.S172S|GPN1_uc010ezg.1_Silent_p.S53S	NM_007266	NP_009197	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1 isoform a	158						cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0						TGGACACATCGAGAAGTACCA	0.443													0	0	0	0.01441	0	65	44										A	27858051	G	A	27858051	2	1	61	1	0	0	0	0	0	0	0	1	6617	1045	37	1		1	GPN1	2	27858051	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	392239	27858051	215341322	33	17535										
CYP1B1	1545	broad.mit.edu	37	chr2	38298398	38298398	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acccatacaaggcagacggtCcctccccacgacctgatcca	7	18	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:38298398C>A	uc002rqo.2	-	4	1502	c.1099G>T	c.(1099-1101)GAC>TAC	p.D367Y		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	367					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	GGCAGACGGTCCCTCCCCACG	0.517													1	0	3.4345e-17	0.011902	3.64915e-17	35	22										A	38298398	C	A	38298398	3	1	61	1	0	0	0	0	1	0	0	0	4151	855	30	3	536	3	CYP1B1	2	38298398	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	10440347	38298398	204900975	34	17536										
SPTBN1	6711	broad.mit.edu	37	chr2	54880916	54880916	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acaggggacaagttccgcttCttcagcatggtgcgcgacct	12	12	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:54880916C>T	uc002rxu.2	+	27	5997	c.5748C>T	c.(5746-5748)TTC>TTT	p.F1916F	SPTBN1_uc002rxx.2_Silent_p.F1903F|SPTBN1_uc002rxy.2_Silent_p.F61F	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1916	Spectrin 16.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGTTCCGCTTCTTCAGCATGG	0.597													0	0	0	0.00632	0	24	13										T	54880916	C	T	54880916	2	4	61	1	0	0	0	0	0	0	0	1	15118	912	32	1		1	SPTBN1	2	54880916	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	16582518	54880916	188318457	35	17537										
SPTBN1	6711	broad.mit.edu	37	chr2	54882218	54882218	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	taattttagggatgtatcatCtgttgaactcttaatgaata	7	4	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:54882218C>G	uc002rxu.2	+	28	6083	c.5834C>G	c.(5833-5835)TCT>TGT	p.S1945C	SPTBN1_uc002rxx.2_Missense_Mutation_p.S1932C|SPTBN1_uc002rxy.2_Missense_Mutation_p.S90C|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1945	Spectrin 16.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GATGTATCATCTGTTGAACTC	0.348													0	0	0	0.008291	0	10	11										G	54882218	C	G	54882218	3	3	61	1	0	0	0	0	1	0	0	0	15118	913	32	1	6053	1	SPTBN1	2	54882218	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1302	54882218	188317155	36	17538										
USP34	9736	broad.mit.edu	37	chr2	61575533	61575533	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctcattgctagatccatcaCtatgcccactactgctacca	4	16	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:61575533C>G	uc002sbe.2	-	15	1779	c.1757G>C	c.(1756-1758)AGT>ACT	p.S586T		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	586					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			AGATCCATCACTATGCCCACT	0.483													0	0	0	0.009096	0	3	196										G	61575533	C	G	61575533	3	3	61	1	0	0	0	0	1	0	0	0	17062	565	20	4	9147	4	USP34	2	61575533	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	6693315	61575533	181623840	37	17539										
ST3GAL5	8869	broad.mit.edu	37	chr2	86090557	86090557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gggtgtaccattgcagggaaGgcctcgagcaatcacttctc	12	11	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:86090557G>A	uc002sqq.1	-	2	263	c.134C>T	c.(133-135)CCT>CTT	p.P45L	ST3GAL5_uc010ysy.1_Missense_Mutation_p.P45L|ST3GAL5_uc010ysz.1_Missense_Mutation_p.P45L|ST3GAL5_uc010fgq.1_5'Flank|ST3GAL5_uc002sqp.1_Missense_Mutation_p.P22L	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	45	Cytoplasmic (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0						TTGCAGGGAAGGCCTCGAGCA	0.498													0	0	0	0.004007	0	15	52										A	86090557	G	A	86090557	3	1	61	1	0	0	0	0	1	0	0	0	15217	1000	35	2	1146	2	ST3GAL5	2	86090557	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	24515024	86090557	157108816	38	17540										
VWA3B	200403	broad.mit.edu	37	chr2	98810866	98810866	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agtttaactttgtgaagtttGatggtcaagcagttgcttgg	12	4	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:98810866G>C	uc002syo.2	+	12	1912	c.1648G>C	c.(1648-1650)GAT>CAT	p.D550H	VWA3B_uc010yvh.1_Missense_Mutation_p.D400H|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.D69H|VWA3B_uc002sym.2_Missense_Mutation_p.D550H|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.D207H|VWA3B_uc002syp.1_5'UTR	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	550	VWFA.									ovary(3)|large_intestine(2)|skin(1)	6						TGTGAAGTTTGATGGTCAAGC	0.373													0	0	0	0.01441	0	78	57										C	98810866	G	C	98810866	3	2	61	1	0	0	0	0	1	0	0	0	17238	1290	45	1	1690	1	VWA3B	2	98810866	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	12720309	98810866	144388507	39	17541										
C2orf15	150590	broad.mit.edu	37	chr2	99767109	99767109	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atcacttaatacgagggactGaaaaaagcaggttggaacca	10	7	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:99767109G>A	uc002szk.2	+	4	589	c.190G>A	c.(190-192)GAA>AAA	p.E64K	TSGA10_uc002szi.3_Intron|MRPL30_uc002szl.1_Intron	NM_144706	NP_653307	Q8WU43	CB015_HUMAN	hypothetical protein LOC150590	64											0						ACGAGGGACTGAAAAAAGCAG	0.363													0	0	0	0.003163	0	12	14										A	99767109	G	A	99767109	3	1	61	1	0	0	0	0	1	0	0	0	2156	1291	45	1	196	1	C2orf15	2	99767109	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	956243	99767109	143432264	40	17542										
PTPN4	5775	broad.mit.edu	37	chr2	120712877	120712877	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agctgaggggcttatcactgGaacagtcctgacacagtttg	12	9	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:120712877G>C	uc002tmf.1	+	20	2729	c.1958G>C	c.(1957-1959)GGA>GCA	p.G653A	PTPN4_uc010flj.1_Missense_Mutation_p.G366A|PTPN4_uc010yyr.1_Missense_Mutation_p.G286A	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	653						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	CTTATCACTGGAACAGTCCTG	0.398													0	0	0	0.003954	0	17	23										C	120712877	G	C	120712877	3	2	61	1	0	0	0	0	1	0	0	0	12790	1174	41	1	2032	1	PTPN4	2	120712877	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	20945768	120712877	122486496	41	17543										
CYP27C1	339761	broad.mit.edu	37	chr2	127951379	127951379	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	actcacgcctttcggaatcaGatacccgccaataaccaggt	7	14	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:127951379G>C	uc002tod.2	-	6	915	c.784C>G	c.(784-786)CTG>GTG	p.L262V		NM_001001665	NP_001001665	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C,	262						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		TTCGGAATCAGATACCCGCCA	0.597													0	0	0	0.004656	0	26	24										C	127951379	G	C	127951379	3	2	61	1	0	0	0	0	1	0	0	0	4160	933	33	1	346	1	CYP27C1	2	127951379	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7238502	127951379	115247994	42	17544										
LRP1B	53353	broad.mit.edu	37	chr2	141128300	141128300	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctttcacagttctcttcatCactgccatccacacagtcat	3	15	6	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:141128300C>T	uc002tvj.1	-	71	11959	c.10987G>A	c.(10987-10989)GAT>AAT	p.D3663N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3663	Extracellular (Potential).|LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCTCTTCATCACTGCCATCC	0.398										TSP Lung(27;0.18)			0	0	0	0.01441	0	118	102										T	141128300	C	T	141128300	3	4	61	1	0	0	0	0	1	0	0	0	8955	826	29	1	2896	1	LRP1B	2	141128300	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	13176921	141128300	102071073	43	17545										
ACVR2A	92	broad.mit.edu	37	chr2	148653908	148653908	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagaaactcaggagtgtcttTtctttaatgctaattgggaa	9	6	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:148653908T>G	uc002twg.2	+	3	363	c.94T>G	c.(94-96)TTC>GTC	p.F32V	ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Missense_Mutation_p.F32V	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	32	Extracellular (Potential).				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		GGAGTGTCTTTTCTTTAATGC	0.348													0	0	0	0.01441	0	34	22										G	148653908	T	G	148653908	3	3	61	1	0	0	0	0	1	0	0	0	223	1841	64	5	100	5	ACVR2A	2	148653908	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	7525608	148653908	94545465	44	17546										
NEB	4703	broad.mit.edu	37	chr2	152397312	152397312	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggtggcaagttcaacatacaGatactgaataatagaagaaa	9	5	1	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:152397312G>C	uc010fnx.2	-	109	15774	c.15583C>G	c.(15583-15585)CTG>GTG	p.L5195V	NEB_uc002txr.2_Missense_Mutation_p.L1618V	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5195	Nebulin 141.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCAACATACAGATACTGAATA	0.418													0	0	0	0.004007	0	15	24										C	152397312	G	C	152397312	3	2	61	1	0	0	0	0	1	0	0	0	10302	933	33	1	5184	1	NEB	2	152397312	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3743404	152397312	90802061	45	17547										
MYO3B	140469	broad.mit.edu	37	chr2	171070928	171070928	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcactgagcttgtcaaaggtCtactcagatgtggccagcgg	12	10	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:171070928C>G	uc002ufy.2	+	4	504	c.361C>G	c.(361-363)CTA>GTA	p.L121V	MYO3B_uc002ufv.2_Missense_Mutation_p.L108V|MYO3B_uc010fqb.1_Missense_Mutation_p.L108V|MYO3B_uc002ufz.2_Missense_Mutation_p.L121V|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Missense_Mutation_p.L108V	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	121	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						TGTCAAAGGTCTACTCAGATG	0.483													0	0	0	0.01441	0	46	48										G	171070928	C	G	171070928	3	3	61	1	0	0	0	0	1	0	0	0	10077	912	32	1	375	1	MYO3B	2	171070928	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	18673616	171070928	72128445	46	17548										
ITGA6	3655	broad.mit.edu	37	chr2	173352763	173352763	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgaactgcttttatcggtctCggggtaagtgtttgtgttta	12	5	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:173352763C>T	uc002uhp.1	+	18	2602	c.2399C>T	c.(2398-2400)TCG>TTG	p.S800L	ITGA6_uc010zdy.1_Missense_Mutation_p.S681L|ITGA6_uc002uho.1_Missense_Mutation_p.S800L|ITGA6_uc010fqm.1_Missense_Mutation_p.S446L	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	839	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TTATCGGTCTCGGGGTAAGTG	0.333													0	0	0	0.006999	0	33	99										T	173352763	C	T	173352763	3	4	61	1	0	0	0	0	1	0	0	0	7880	893	31	1	2469	1	ITGA6	2	173352763	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2281835	173352763	69846610	47	17549										
PLEKHA3	65977	broad.mit.edu	37	chr2	179358588	179358588	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tattcttttcagaaataagtGaaaccagtgaatcgctgaaa	7	6	2	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:179358588G>A	uc002umn.2	+	4	720	c.322G>A	c.(322-324)GAA>AAA	p.E108K		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	108						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			AGAAATAAGTGAAACCAGTGA	0.308													0	0	0	0.004482	0	6	24										A	179358588	G	A	179358588	3	1	61	1	0	0	0	0	1	0	0	0	12057	1291	45	1	336	1	PLEKHA3	2	179358588	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6005825	179358588	63840785	48	17550										
BMPR2	659	broad.mit.edu	37	chr2	203397422	203397422	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctcttggactaatctattggGagatatttatgagatgtaca	9	5	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:203397422G>C	uc002uzf.3	+	9	2391	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	BMPR2_uc010ftr.2_Missense_Mutation_p.E415Q	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	415	Protein kinase.|Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AATCTATTGGGAGATATTTAT	0.373													0	0	0	0.007291	0	23	19										C	203397422	G	C	203397422	3	2	61	1	0	0	0	0	1	0	0	0	1471	1175	41	1	1277	1	BMPR2	2	203397422	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	24038834	203397422	39801951	49	17551										
IKZF2	22807	broad.mit.edu	37	chr2	213914495	213914495	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cttctacaggcgtagctacaGaaaggacatttgaacggctt	10	9	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:213914495G>T	uc002vem.2	-	5	685	c.516C>A	c.(514-516)TTC>TTA	p.F172L	IKZF2_uc010fuu.2_Intron|IKZF2_uc002vej.2_Missense_Mutation_p.F119L|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.F146L|IKZF2_uc002vel.2_Missense_Mutation_p.F93L|IKZF2_uc010fuw.2_Translation_Start_Site|IKZF2_uc010fux.2_Translation_Start_Site|IKZF2_uc010fuy.2_Missense_Mutation_p.F146L|IKZF2_uc002ven.2_Missense_Mutation_p.F146L	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	172	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CGTAGCTACAGAAAGGACATT	0.473													1	0	2.41591e-17	0.004656	2.57245e-17	23	37										T	213914495	G	T	213914495	3	4	61	1	0	0	0	0	1	0	0	0	7615	933	33	3	1080	3	IKZF2	2	213914495	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	10517073	213914495	29284878	50	17552										
NHEJ1	79840	broad.mit.edu	37	chr2	220022246	220022246	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tccaatagaaggggaggccaGagagctcacttcgcacccgt	12	12	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:220022246G>C	uc002vjp.3	-	3	484	c.338C>G	c.(337-339)TCT>TGT	p.S113C	NHEJ1_uc002vjq.3_RNA	NM_024782	NP_079058	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	113					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		GGGGAGGCCAGAGAGCTCACT	0.527								Direct_reversal_of_damage|NHEJ					0	0	0	0.005524	0	32	33										C	220022246	G	C	220022246	3	2	61	1	0	0	0	0	1	0	0	0	10402	942	33	1	585	1	NHEJ1	2	220022246	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6107751	220022246	23177127	51	17553										
C2orf24	27013	broad.mit.edu	37	chr2	220041503	220041503	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtgaagtcctggaagccggcGagggagaaggtgccttcttc	16	9	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:220041503G>A	uc002vju.3	-	1	200	c.48C>T	c.(46-48)CTC>CTT	p.L16L	C2orf24_uc002vjv.2_Silent_p.L16L|FAM134A_uc002vjw.3_5'Flank|FAM134A_uc010fwc.2_5'Flank	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	16					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAGCCGGCGAGGGAGAAGG	0.711													0	0	0	0.001984	0	4	3										A	220041503	G	A	220041503	2	1	61	1	0	0	0	0	0	0	0	1	2159	1045	37	1		1	C2orf24	2	220041503	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	19257	220041503	23157870	52	17554										
STK11IP	114790	broad.mit.edu	37	chr2	220470931	220470931	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctcagctctacctggagggGaaccctctttggttccaccc	9	16	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:220470931G>C	uc002vml.2	+	10	940	c.897G>C	c.(895-897)GGG>GGC	p.G299G	STK11IP_uc010zlk.1_Silent_p.G288G|STK11IP_uc010zll.1_Intron|STK11IP_uc002vmm.1_Silent_p.G288G	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	299	LRR 8.				protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCTGGAGGGGAACCCTCTTT	0.632											OREG0003992	type=REGULATORY REGION|Gene=STK11IP|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004672	0	2	6										C	220470931	G	C	220470931	2	2	61	1	0	0	0	0	0	0	0	1	15287	1161	41	1		1	STK11IP	2	220470931	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	429428	220470931	22728442	53	17555										
CCDC140	151278	broad.mit.edu	37	chr2	223169071	223169071	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaaaagaagaaagagagaaaGagaagaaaagagagaaagaa	12	0	0	9			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:223169071G>C	uc002vnb.1	+	2	834	c.450G>C	c.(448-450)AAG>AAC	p.K150N		NM_153038	NP_694583	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	150	Potential.										0		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		aagagagaaagagaagaaaag	0.398													0	0	0	0.000602	0	5	2										C	223169071	G	C	223169071	3	2	61	1	0	0	0	0	1	0	0	0	2774	933	33	1	452	1	CCDC140	2	223169071	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2698140	223169071	20030302	54	17556										
TRIP12	9320	broad.mit.edu	37	chr2	230661454	230661454	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatgaaacatctgactctgaGactatgctacggatttctac	8	9	3	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:230661454G>A	uc002vpw.1	-	24	3553	c.3444C>T	c.(3442-3444)GTC>GTT	p.V1148V	TRIP12_uc002vpx.1_Silent_p.V1196V|TRIP12_uc002vpy.1_Silent_p.V878V|TRIP12_uc010zlz.1_RNA	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1148					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CTGACTCTGAGACTATGCTAC	0.373													0	0	0	0.003954	0	19	43										A	230661454	G	A	230661454	2	1	61	1	0	0	0	0	0	0	0	1	16553	929	33	1		1	TRIP12	2	230661454	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7492383	230661454	12537919	55	17557										
RNPEPL1	57140	broad.mit.edu	37	chr2	241516112	241516112	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcggccagcgccattgacatCtccaagtggaggaccttcca	10	14	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr2:241516112C>G	uc002vzi.2	+	9	1571	c.978C>G	c.(976-978)ATC>ATG	p.I326M	RNPEPL1_uc010fzf.2_Missense_Mutation_p.I232M|RNPEPL1_uc002vzj.2_Translation_Start_Site	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	326					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CCATTGACATCTCCAAGTGGA	0.672													0	0	0	0.01441	0	48	30										G	241516112	C	G	241516112	3	3	61	1	0	0	0	0	1	0	0	0	13510	903	32	1	1004	1	RNPEPL1	2	241516112	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	10854658	241516112	1683261	56	17558										
MTMR14	64419	broad.mit.edu	37	chr3	9743604	9743604	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtgccatcgggggcctgctgGagcaatttgcccgtggtgtt	16	10	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:9743604G>C	uc003brz.2	+	19	2024	c.1900G>C	c.(1900-1902)GAG>CAG	p.E634Q	MTMR14_uc003bsa.2_Missense_Mutation_p.E582Q|MTMR14_uc003bsb.2_Missense_Mutation_p.E522Q|MTMR14_uc011ath.1_RNA|MTMR14_uc010hcl.2_Missense_Mutation_p.E276Q|MTMR14_uc003bsc.2_RNA|CPNE9_uc003bsd.2_5'Flank	NM_001077525	NP_001070993	Q8NCE2	MTMRE_HUMAN	jumpy isoform 2	634						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(99;0.227)					GGGCCTGCTGGAGCAATTTGC	0.617													0	0	0	0.01441	0	49	76										C	9743604	G	C	9743604	3	2	61	1	0	0	0	0	1	0	0	0	9942	1175	41	1	1974	1	MTMR14	3	9743604	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		9743604	188278826	57	17559										
HRH1	3269	broad.mit.edu	37	chr3	11300932	11300932	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctgtacatcgtcagcctctCggtggcggacttgatcgtgg	13	12	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:11300932C>T	uc010hdr.2	+	2	551	c.209C>T	c.(208-210)TCG>TTG	p.S70L	HRH1_uc010hds.2_Missense_Mutation_p.S70L|HRH1_uc010hdt.2_Missense_Mutation_p.S70L|HRH1_uc003bwb.3_Missense_Mutation_p.S70L	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	70	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GTCAGCCTCTCGGTGGCGGAC	0.577													0	0	0	0.01441	0	43	45										T	11300932	C	T	11300932	3	4	61	1	0	0	0	0	1	0	0	0	7355	893	31	1	211	1	HRH1	3	11300932	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1557328	11300932	186721498	58	17560										
NGLY1	55768	broad.mit.edu	37	chr3	25805630	25805630	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggtttaacccactgggatttGaagatggtgttgtaggaagc	14	5	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:25805630G>C	uc003cdl.2	-	3	527	c.419C>G	c.(418-420)TCA>TGA	p.S140*	NGLY1_uc010hfg.2_Nonsense_Mutation_p.S140*|NGLY1_uc003cdm.2_Nonsense_Mutation_p.S140*|NGLY1_uc011awo.1_Nonsense_Mutation_p.S98*|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	140					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						ACTGGGATTTGAAGATGGTGT	0.448													0	0	0	0.01441	0	47	55										C	25805630	G	C	25805630	4	2	61	1	0	0	0	0	0	1	0	0	10398	1294	45	1	1681	1	NGLY1	3	25805630	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14504698	25805630	172216800	59	17561										
KIF15	56992	broad.mit.edu	37	chr3	44835802	44835802	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccgtctttacaattacaataGagtcaatggagaaaagtaat	7	6	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:44835802G>C	uc003cnx.3	+	8	882	c.733G>C	c.(733-735)GAG>CAG	p.E245Q	KIF15_uc010hiq.2_Missense_Mutation_p.E148Q	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	245	Kinesin-motor.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AATTACAATAGAGTCAATGGA	0.428													0	0	0	0.010771	0	40	66										C	44835802	G	C	44835802	3	2	61	1	0	0	0	0	1	0	0	0	8277	943	33	1	763	1	KIF15	3	44835802	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	19030172	44835802	153186628	60	17562										
SEMA3F	6405	broad.mit.edu	37	chr3	50222226	50222226	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atgcagccgacgggcgctatGaggtgcttttcctgggcaca	14	11	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:50222226G>A	uc003cyj.2	+	13	1633	c.1435G>A	c.(1435-1437)GAG>AAG	p.E479K	SEMA3F_uc003cyk.2_Missense_Mutation_p.E448K	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	479	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CGGGCGCTATGAGGTGCTTTT	0.682													0	0	0	0.006122	0	15	16										A	50222226	G	A	50222226	3	1	61	1	0	0	0	0	1	0	0	0	14029	1291	45	1	1481	1	SEMA3F	3	50222226	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5386424	50222226	147800204	61	17563										
GLT8D1	55830	broad.mit.edu	37	chr3	52730304	52730304	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cttctttgcgctgggaaccaGaattggcaagtagaaccttg	11	9	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:52730304G>A	uc003dfi.3	-	6	617	c.478C>T	c.(478-480)CTG>TTG	p.L160L	GLT8D1_uc003dfj.2_Silent_p.L160L|GLT8D1_uc003dfk.2_Silent_p.L160L|GLT8D1_uc003dfl.2_Silent_p.L160L|GLT8D1_uc003dfm.2_Silent_p.L160L|GLT8D1_uc003dfn.2_Silent_p.L160L|GLT8D1_uc003dfo.1_Silent_p.L160L	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	160	Lumenal (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTGGGAACCAGAATTGGCAAG	0.418													0	0	0	0.009096	0	3	61										A	52730304	G	A	52730304	2	1	61	1	0	0	0	0	0	0	0	1	6469	933	33	1		1	GLT8D1	3	52730304	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2508078	52730304	145292126	62	17564										
ACTR8	93973	broad.mit.edu	37	chr3	53908332	53908332	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctctgtaagggaacccagctCgctgcattagccagtaaaaa	9	11	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:53908332C>T	uc003dhd.2	-	8	1030	c.971G>A	c.(970-972)CGA>CAA	p.R324Q	ACTR8_uc003dhb.2_Intron|ACTR8_uc003dhc.2_Missense_Mutation_p.R213Q	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	324					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		GAACCCAGCTCGCTGCATTAG	0.398													0	0	0	0.013726	0	29	28										T	53908332	C	T	53908332	3	4	61	1	0	0	0	0	1	0	0	0	217	884	31	1	927	1	ACTR8	3	53908332	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1178028	53908332	144114098	63	17565										
PRICKLE2	166336	broad.mit.edu	37	chr3	64132939	64132939	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agagggctctgggtctggttCtgctccatcttgttcccata	11	11	4	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:64132939C>G	uc003dmf.2	-	7	1813	c.1227G>C	c.(1225-1227)CAG>CAC	p.Q409H		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	409						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GGGTCTGGTTCTGCTCCATCT	0.612													0	0	0	0.01441	0	50	73										G	64132939	C	G	64132939	3	3	61	1	0	0	0	0	1	0	0	0	12487	912	32	1	1315	1	PRICKLE2	3	64132939	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	10224607	64132939	133889491	64	17566										
ROBO2	6092	broad.mit.edu	37	chr3	77623749	77623749	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcagaatttagatgccaaaGtcccgactgaacgaagtgct	11	9	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:77623749G>T	uc003dpy.3	+	14	2714	c.2071G>T	c.(2071-2073)GTC>TTC	p.V691F	ROBO2_uc003dpz.2_Missense_Mutation_p.V695F|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V695F	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	691	Fibronectin type-III 2.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGATGCCAAAGTCCCGACTGA	0.458													1	0	0.004672	0.004672	0.00475888	3	92										T	77623749	G	T	77623749	3	4	61	1	0	0	0	0	1	0	0	0	13514	1029	36	4	2127	4	ROBO2	3	77623749	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	13490810	77623749	120398681	65	17567										
SENP7	57337	broad.mit.edu	37	chr3	101060619	101060619	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcttggccgcatctgtgtttGagggctgacagaaagtggca	15	8	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:101060619G>C	uc003dut.2	-	15	2222	c.2111C>G	c.(2110-2112)TCA>TGA	p.S704*	SENP7_uc003duu.2_Nonsense_Mutation_p.S639*|SENP7_uc003duv.2_Nonsense_Mutation_p.S671*|SENP7_uc003duw.2_Nonsense_Mutation_p.S638*|SENP7_uc003dux.2_Nonsense_Mutation_p.S540*	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	704					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						ATCTGTGTTTGAGGGCTGACA	0.418													0	0	0	0.007413	0	14	22										C	101060619	G	C	101060619	4	2	61	1	0	0	0	0	0	1	0	0	14051	1294	45	1	1081	1	SENP7	3	101060619	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	23436870	101060619	96961811	66	17568										
ATG3	64422	broad.mit.edu	37	chr3	112255401	112255401	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cactgttttcttcacatgatCctgactgatgtcttcataca	5	11	4	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:112255401C>G	uc003dzd.2	-	10	825	c.715G>C	c.(715-717)GAT>CAT	p.D239H	ATG3_uc003dzc.2_Missense_Mutation_p.D239H|ATG3_uc010hqe.2_Missense_Mutation_p.D239H	NM_022488	NP_071933	Q9NT62	ATG3_HUMAN	Apg3p	239					autophagic vacuole assembly|mitochondrial fragmentation involved in apoptosis|protein targeting to membrane|protein ubiquitination	cytoplasmic ubiquitin ligase complex|cytosol	Atg12 ligase activity|Atg8 ligase activity|enzyme binding			ovary(3)	3						TTCACATGATCCTGACTGATG	0.368													0	0	0	0.003755	0	35	50										G	112255401	C	G	112255401	3	3	61	1	0	0	0	0	1	0	0	0	1095	855	30	1	241	1	ATG3	3	112255401	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	11194782	112255401	85767029	67	17569										
DIRC2	84925	broad.mit.edu	37	chr3	122552196	122552196	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctgcttaatattttctgcaAcactagcttatttcccaccc	3	13	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:122552196A>T	uc003efw.3	+	4	875	c.736A>T	c.(736-738)ACA>TCA	p.T246S	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.T84S	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	246	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		ATTTTCTGCAACACTAGCTTA	0.393													0	0	0	0.003954	0	21	152										T	122552196	A	T	122552196	3	4	61	1	0	0	0	0	1	0	0	0	4534	43	2	5	750	5	DIRC2	3	122552196	Missense_Mutation	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	10296795	122552196	75470234	68	17570										
SEMA5B	54437	broad.mit.edu	37	chr3	122646670	122646670	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggagttatattgggcagtgcGaagcggtggcccactgccca	15	10	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:122646670G>T	uc003efz.1	-	8	1121	c.817C>A	c.(817-819)CGC>AGC	p.R273S	SEMA5B_uc011bju.1_Missense_Mutation_p.R215S|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.R273S|SEMA5B_uc010hro.1_Missense_Mutation_p.R215S|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	273	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGGGCAGTGCGAAGCGGTGGC	0.627													1	0	9.9191e-30	0.00874	1.08188e-29	30	38										T	122646670	G	T	122646670	3	4	61	1	0	0	0	0	1	0	0	0	14038	1058	37	3	2702	3	SEMA5B	3	122646670	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	94474	122646670	75375760	69	17571										
RUVBL1	8607	broad.mit.edu	37	chr3	127842458	127842458	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctcctggcccacaagccctGaggccgcctgcttggccaag	11	17	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:127842458G>A	uc003ekh.2	-	1	214	c.110C>T	c.(109-111)TCA>TTA	p.S37L	RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Missense_Mutation_p.S37L	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	37					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CACAAGCCCTGAGGCCGCCTG	0.667													0	0	0	0.003954	0	22	17										A	127842458	G	A	127842458	3	1	61	1	0	0	0	0	1	0	0	0	13752	1294	45	1	1304	1	RUVBL1	3	127842458	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5195788	127842458	70179972	70	17572										
CCDC48	79825	broad.mit.edu	37	chr3	128758636	128758636	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gctgttgcggagacagccctCggcaccagcctctgcagcag	13	15	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:128758636C>T	uc011bkt.1	+	8	1742	c.1742C>T	c.(1741-1743)TCG>TTG	p.S581L		NM_024768	NP_079044	Q9HA90	CCD48_HUMAN	coiled-coil domain containing 48	581											0						AGACAGCCCTCGGCACCAGCC	0.667													0	0	0	0.01441	0	56	48										T	128758636	C	T	128758636	3	4	61	1	0	0	0	0	1	0	0	0	2819	893	31	1	1772	1	CCDC48	3	128758636	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	916178	128758636	69263794	71	17573										
MRPS22	56945	broad.mit.edu	37	chr3	139062910	139062910	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtattgctgtggagcctcttGaggagttctccgggcgtgga	16	8	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:139062910G>C	uc003etb.2	+	1	50	c.42G>C	c.(40-42)TTG>TTC	p.L14F	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.L14F|MRPS22_uc003ete.2_5'Flank	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	14						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GGAGCCTCTTGAGGAGTTCTC	0.602													0	0	0	0.003954	0	20	30										C	139062910	G	C	139062910	3	2	61	1	0	0	0	0	1	0	0	0	9833	1281	45	1	44	1	MRPS22	3	139062910	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	10304274	139062910	58959520	72	17574										
ZBTB38	253461	broad.mit.edu	37	chr3	141162438	141162438	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aagccacatgcccattcctgGaggaaaccaacgctttttag	8	12	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:141162438G>C	uc003etw.2	+	8	2190	c.1208G>C	c.(1207-1209)GGA>GCA	p.G403A	ZBTB38_uc010hun.2_Missense_Mutation_p.G400A|ZBTB38_uc010huo.2_Missense_Mutation_p.G403A|ZBTB38_uc003ety.2_Missense_Mutation_p.G403A|ZBTB38_uc010hup.2_Missense_Mutation_p.G404A	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	403					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CCCATTCCTGGAGGAAACCAA	0.428													0	0	0	0.01441	0	47	51										C	141162438	G	C	141162438	3	2	61	1	0	0	0	0	1	0	0	0	17536	1174	41	1	1210	1	ZBTB38	3	141162438	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2099528	141162438	56859992	73	17575										
C3orf57	165679	broad.mit.edu	37	chr3	161064103	161064103	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaatattccttcacacgcctCaaatccatggttggctcctt	5	13	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:161064103C>G	uc003fee.2	-	3	783	c.9G>C	c.(7-9)TTG>TTC	p.L3F		NM_001040100	NP_001035189	Q8NFR3	SSPTB_HUMAN	ADMP	3	Cytoplasmic (Potential).				sphingolipid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	protein binding				0			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TCACACGCCTCAAATCCATGG	0.403													0	0	0	0.008361	0	24	33										G	161064103	C	G	161064103	3	3	61	1	0	0	0	0	1	0	0	0	2235	825	29	1	225	1	C3orf57	3	161064103	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	19901665	161064103	36958327	74	17576										
MECOM	2122	broad.mit.edu	37	chr3	168830619	168830619	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agaaggcctcaagtatttctCttttaaagcttcaagtgggt	9	7	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:168830619C>G	uc003ffi.3	-	8	2238	c.1969G>C	c.(1969-1971)GAG>CAG	p.E657Q	MECOM_uc010hwk.1_Missense_Mutation_p.E680Q|MECOM_uc003ffj.3_Missense_Mutation_p.E722Q|MECOM_uc011bpi.1_Missense_Mutation_p.E658Q|MECOM_uc003ffn.3_Missense_Mutation_p.E657Q|MECOM_uc003ffk.2_Missense_Mutation_p.E657Q|MECOM_uc003ffl.2_Missense_Mutation_p.E817Q|MECOM_uc011bpj.1_Missense_Mutation_p.E845Q|MECOM_uc011bpk.1_Missense_Mutation_p.E647Q|MECOM_uc010hwn.2_Missense_Mutation_p.E845Q	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	657					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						AAGTATTTCTCTTTTAAAGCT	0.353													0	0	0	0.004878	0	28	43										G	168830619	C	G	168830619	3	3	61	1	0	0	0	0	1	0	0	0	9422	922	32	1	1222	1	MECOM	3	168830619	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	7766516	168830619	29191811	75	17577										
KLHL6	89857	broad.mit.edu	37	chr3	183273151	183273151	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggtcctaggcatgctgacctGaaatagttgctggctgcggc	14	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:183273151G>T	uc003flr.2	-	1	349	c.291C>A	c.(289-291)TTC>TTA	p.F97L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Missense_Mutation_p.F95L	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	97	BTB.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			ATGCTGACCTGAAATAGTTGC	0.502													1	0	2.01807e-28	0.01441	2.19627e-28	43	72										T	183273151	G	T	183273151	3	4	61	1	0	0	0	0	1	0	0	0	8393	1281	45	3	1602	3	KLHL6	3	183273151	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14442532	183273151	14749279	76	17578										
C3orf70	285382	broad.mit.edu	37	chr3	184870595	184870595	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaccccgctccgacgccggcGaggccgccgcactcatttcc	10	20	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr3:184870595G>A	uc003fpd.2	-	1	208	c.17C>T	c.(16-18)TCG>TTG	p.S6L		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	6											0						CGACGCCGGCGAGGCCGCCGC	0.716													0	0	0	0.006122	0	15	19										A	184870595	G	A	184870595	3	1	61	1	0	0	0	0	1	0	0	0	2242	1059	37	1	743	1	C3orf70	3	184870595	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1597444	184870595	13151835	77	17579										
TACC3	10460	broad.mit.edu	37	chr4	1737475	1737475	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagtttaaggagtcggccttGaggaagcagtccttatacct	11	9	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:1737475G>T	uc003gdo.2	+	8	1770	c.1662G>T	c.(1660-1662)TTG>TTT	p.L554F	TACC3_uc010ibz.2_Missense_Mutation_p.L554F|TACC3_uc003gdp.2_Missense_Mutation_p.L194F|TACC3_uc010ica.2_5'UTR	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	554						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AGTCGGCCTTGAGGAAGCAGT	0.607													1	0	1.7941499863079e-318	0.01441	1.97878231815878e-318	518	302										T	1737475	G	T	1737475	3	4	61	1	0	0	0	0	1	0	0	0	15500	1281	45	3	1688	3	TACC3	4	1737475	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		1737475	189416801	78	17580										
FGFR3	2261	broad.mit.edu	37	chr4	1803377	1803377	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agcagtggagcctggtcatgGaaagcgtggtgccctcggac	16	10	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:1803377G>A	uc003gdr.3	+	6	902	c.646G>A	c.(646-648)GAA>AAA	p.E216K	FGFR3_uc003gdu.2_Missense_Mutation_p.E216K|FGFR3_uc003gds.3_Missense_Mutation_p.E216K|FGFR3_uc003gdq.3_Missense_Mutation_p.E216K|FGFR3_uc010icb.1_Missense_Mutation_p.E58K|FGFR3_uc003gdt.1_Missense_Mutation_p.E58K	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	216	Extracellular (Potential).|Ig-like C2-type 2.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCTGGTCATGGAAAGCGTGGT	0.677		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.014323	0	16	288										A	1803377	G	A	1803377	3	1	61	1	0	0	0	0	1	0	0	0	5867	1175	41	1	664	1	FGFR3	4	1803377	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	65902	1803377	189350899	79	17581			1	73		4	4	5561	N	G_C	6.757851e-05
FGFR3	2261	broad.mit.edu	37	chr4	1803395	1803395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tggaaagcgtggtgccctcgGaccgcggcaactacacctgc	13	14	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:1803395G>A	uc003gdr.3	+	6	920	c.664G>A	c.(664-666)GAC>AAC	p.D222N	FGFR3_uc003gdu.2_Missense_Mutation_p.D222N|FGFR3_uc003gds.3_Missense_Mutation_p.D222N|FGFR3_uc003gdq.3_Missense_Mutation_p.D222N|FGFR3_uc010icb.1_Missense_Mutation_p.D64N|FGFR3_uc003gdt.1_Missense_Mutation_p.D64N	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	222	Extracellular (Potential).|Ig-like C2-type 2.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GGTGCCCTCGGACCGCGGCAA	0.672		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00278	0	15	292										A	1803395	G	A	1803395	3	1	61	1	0	0	0	0	1	0	0	0	5867	1174	41	1	682	1	FGFR3	4	1803395	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	18	1803395	189350881	80	17582			1	73		4	4	5561	N	G_C	6.757851e-05
FGFR3	2261	broad.mit.edu	37	chr4	1803435	1803435	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgtcgtggagaacaagtttgGcagcatccggcagacgtaca	13	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:1803435G>A	uc003gdr.3	+	6	960	c.704G>A	c.(703-705)GGC>GAC	p.G235D	FGFR3_uc003gdu.2_Missense_Mutation_p.G235D|FGFR3_uc003gds.3_Missense_Mutation_p.G235D|FGFR3_uc003gdq.3_Missense_Mutation_p.G235D|FGFR3_uc010icb.1_Missense_Mutation_p.G77D|FGFR3_uc003gdt.1_Missense_Mutation_p.G77D	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	235	Extracellular (Potential).|Ig-like C2-type 2.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	AACAAGTTTGGCAGCATCCGG	0.522		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.010729	0	9	270										A	1803435	G	A	1803435	3	1	61	1	0	0	0	0	1	0	0	0	5867	1203	42	2	722	2	FGFR3	4	1803435	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	40	1803435	189350841	81	17583			1	73		4	4	5561	N	G_C	6.757851e-05
FGFR3	2261	broad.mit.edu	37	chr4	1808937	1808937	+	Frame_Shift_Del	DEL	C	C	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aggggacgactccgtgtttgCccacgacctgctgcccccgg							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:1808937delC	uc003gdr.3	+	18	2625	c.2369delC	c.(2368-2370)GCCfs	p.A790fs	FGFR3_uc003gdu.2_Frame_Shift_Del_p.A792fs|FGFR3_uc003gds.3_Frame_Shift_Del_p.A678fs|FGFR3_uc003gdq.3_Frame_Shift_Del_p.C767fs	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	790	Cytoplasmic (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TCCGTGTTTGCCCACGACCTG	0.687		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome									265	83	---	---								-	1808937	C	-	1808937	7	5	61	1	0	1	0	1	0	0	0	0	5867	739	26	0	2590	0	FGFR3	4	1808937	Frame_Shift_Del	DEL	C	TCGA-DK-A3IS-01A-21D-A21A-08	5502	1808937	189345339	82	17584			1	73		4	4	5561	N	G_C	6.757851e-05
WHSC2	7469	broad.mit.edu	37	chr4	1985607	1985607	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gttcttcttaggctgctgctGagcaggggcctgggtctgcg	16	10	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:1985607G>A	uc003gem.2	-	9	1543	c.1303C>T	c.(1303-1305)CAG>TAG	p.Q435*	WHSC2_uc003gek.2_Nonsense_Mutation_p.Q161*|WHSC2_uc003gel.2_Nonsense_Mutation_p.Q349*|WHSC2_uc003gen.2_Nonsense_Mutation_p.Q289*	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	424					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GGCTGCTGCTGAGCAGGGGCC	0.672													0	0	0	0.01441	0	58	39										A	1985607	G	A	1985607	4	1	61	1	0	0	0	0	0	1	0	0	17361	1299	45	1	328	1	WHSC2	4	1985607	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	176670	1985607	189168669	83	17585										
POLN	353497	broad.mit.edu	37	chr4	2129877	2129877	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agaaaatacatcatctctttCagattcctggaataacttca	4	9	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:2129877C>G	uc003ger.2	-	17	1945	c.1945G>C	c.(1945-1947)GAA>CAA	p.E649Q	POLN_uc010icg.1_Missense_Mutation_p.E97Q|POLN_uc010ich.1_Missense_Mutation_p.E181Q	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	649					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TCATCTCTTTCAGATTCCTGG	0.373								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	40	25										G	2129877	C	G	2129877	3	3	61	1	0	0	0	0	1	0	0	0	12207	835	29	1	789	1	POLN	4	2129877	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	144270	2129877	189024399	84	17586										
POLN	353497	broad.mit.edu	37	chr4	2130961	2130961	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aacatggccctcggggagatCgtgagaatcttgtcttcttt	11	9	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:2130961C>G	uc003ger.2	-	16	1812	c.1812G>C	c.(1810-1812)ACG>ACC	p.T604T	POLN_uc010icg.1_Silent_p.T52T|POLN_uc010ich.1_Silent_p.T136T	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	604					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TCGGGGAGATCGTGAGAATCT	0.393								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	63	46										G	2130961	C	G	2130961	2	3	61	1	0	0	0	0	0	0	0	1	12207	871	31	1		1	POLN	4	2130961	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1084	2130961	189023315	85	17587										
POLN	353497	broad.mit.edu	37	chr4	2130975	2130975	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggagatcgtgagaatcttgtCttctttacctgaattgttat	9	6	3	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:2130975C>T	uc003ger.2	-	16	1798	c.1798G>A	c.(1798-1800)GAC>AAC	p.D600N	POLN_uc010icg.1_Missense_Mutation_p.D48N|POLN_uc010ich.1_Missense_Mutation_p.D132N	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	600					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			AGAATCTTGTCTTCTTTACCT	0.378								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	40	38										T	2130975	C	T	2130975	3	4	61	1	0	0	0	0	1	0	0	0	12207	913	32	1	940	1	POLN	4	2130975	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	14	2130975	189023301	86	17588										
HTT	3064	broad.mit.edu	37	chr4	3241734	3241734	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcagccccaggaagcccatAtcaccggctgctgacttgtt	10	14	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:3241734A>G	uc011bvq.1	+	68	9528	c.9383A>G	c.(9382-9384)TAT>TGT	p.Y3128C		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	3126					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGAAGCCCATATCACCGGCTG	0.602													0	0	0	0.000602	0	4	14										G	3241734	A	G	3241734	3	3	61	1	0	0	0	0	1	0	0	0	7457	449	16	5	9643	5	HTT	4	3241734	Missense_Mutation	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	1110759	3241734	187912542	87	17589										
OTOP1	133060	broad.mit.edu	37	chr4	4199404	4199404	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggtccgagtccagtttgcggGccggatttttggactcatcc	13	11	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:4199404G>A	uc003ghp.1	-	5	1187	c.1157C>T	c.(1156-1158)GCC>GTC	p.A386V		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	386					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CAGTTTGCGGGCCGGATTTTT	0.592													0	0	0	0.005524	0	31	39										A	4199404	G	A	4199404	3	1	61	1	0	0	0	0	1	0	0	0	11305	1203	42	2	689	2	OTOP1	4	4199404	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	957670	4199404	186954872	88	17590										
TBC1D14	57533	broad.mit.edu	37	chr4	6925317	6925317	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctccagtccgtggactcgggGattcctaccctggagatcgg	13	13	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:6925317G>A	uc011bwg.1	+	2	280	c.201G>A	c.(199-201)GGG>GGA	p.G67G	TBC1D14_uc003gjs.3_Silent_p.G67G	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	67						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						TGGACTCGGGGATTCCTACCC	0.652													0	0	0	0.004482	0	7	87										A	6925317	G	A	6925317	2	1	61	1	0	0	0	0	0	0	0	1	15600	1161	41	1		1	TBC1D14	4	6925317	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2725913	6925317	184228959	89	17591										
TBC1D14	57533	broad.mit.edu	37	chr4	6969065	6969065	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaaaacaaagtgcaaggcttGacaaacacaatgacttggga	10	7	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:6969065G>C	uc011bwg.1	+	3	836	c.757G>C	c.(757-759)GAC>CAC	p.D253H	TBC1D14_uc003gjs.3_Missense_Mutation_p.D253H	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	253						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						TGCAAGGCTTGACAAACACAA	0.413													0	0	0	0.008291	0	8	136										C	6969065	G	C	6969065	3	2	61	1	0	0	0	0	1	0	0	0	15600	1290	45	1	763	1	TBC1D14	4	6969065	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	43748	6969065	184185211	90	17592										
ACOX3	8310	broad.mit.edu	37	chr4	8396454	8396454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtagacagctgccagatatgGaagcaagcgccattgctaga	12	9	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:8396454G>A	uc010idk.2	-	10	1217	c.1072C>T	c.(1072-1074)CCA>TCA	p.P358S	ACOX3_uc003glc.3_Missense_Mutation_p.P358S|ACOX3_uc003gld.3_Missense_Mutation_p.P358S|ACOX3_uc003gle.1_Missense_Mutation_p.P263S	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	358					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						GCCAGATATGGAAGCAAGCGC	0.577													0	0	0	0.00245	0	13	139										A	8396454	G	A	8396454	3	1	61	1	0	0	0	0	1	0	0	0	160	1174	41	1	1066	1	ACOX3	4	8396454	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1427389	8396454	182757822	91	17593										
GBA3	57733	broad.mit.edu	37	chr4	22748956	22748956	+	Frame_Shift_Del	DEL	A	A	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aagatcatcgatgatttgttAaaaaatggggttactcccat							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:22748956delA	uc003gqp.3	+	3	415	c.324delA	c.(322-324)TTAfs	p.L108fs	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Frame_Shift_Del_p.L109fs	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	108					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						ATGATTTGTTAAAAAATGGGG	0.363																		12	208	---	---								-	22748956	A	-	22748956	7	5	61	1	0	1	0	1	0	0	0	0	6268	359	13	0	334	0	GBA3	4	22748956	Frame_Shift_Del	DEL	A	TCGA-DK-A3IS-01A-21D-A21A-08	14352502	22748956	168405320	92	17594										
TMEM156	80008	broad.mit.edu	37	chr4	39000395	39000395	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acgaaaattggagggatttaGaaagattctcatgataatct	9	4	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:39000395G>C	uc003gto.2	-	2	331	c.223C>G	c.(223-225)CTA>GTA	p.L75V	TMEM156_uc010ifj.2_Missense_Mutation_p.L75V	NM_024943	NP_079219	Q8N614	TM156_HUMAN	transmembrane protein 156	75	Extracellular (Potential).					integral to membrane				skin(1)	1						GAGGGATTTAGAAAGATTCTC	0.363													0	0	0	0.003954	0	18	13										C	39000395	G	C	39000395	3	2	61	1	0	0	0	0	1	0	0	0	16070	933	33	1	687	1	TMEM156	4	39000395	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	16251439	39000395	152153881	93	17595										
N4BP2	55728	broad.mit.edu	37	chr4	40122276	40122276	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatctccacatgaaagtgtaGaggatggcagaaagtcacag	12	7	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:40122276G>C	uc003guy.3	+	9	2883	c.2545G>C	c.(2545-2547)GAG>CAG	p.E849Q	N4BP2_uc010ifq.2_Missense_Mutation_p.E769Q|N4BP2_uc010ifr.2_Missense_Mutation_p.E769Q	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	849						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TGAAAGTGTAGAGGATGGCAG	0.358													0	0	0	0.00874	0	36	45										C	40122276	G	C	40122276	3	2	61	1	0	0	0	0	1	0	0	0	10110	943	33	1	2571	1	N4BP2	4	40122276	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1121881	40122276	151032000	94	17596										
FRYL	285527	broad.mit.edu	37	chr4	48503750	48503750	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcttcggcagagctccaattCctagaaataaataacattac	5	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:48503750C>G	uc003gyh.1	-	62	9087	c.8482G>C	c.(8482-8484)GAA>CAA	p.E2828Q	FRYL_uc003gye.1_Missense_Mutation_p.E10Q|FRYL_uc003gyf.1_Missense_Mutation_p.E218Q|FRYL_uc003gyg.1_Missense_Mutation_p.E1518Q	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2828					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AGCTCCAATTCCTAGAAATAA	0.294													0	0	0	0.01441	0	62	46										G	48503750	C	G	48503750	3	3	61	1	0	0	0	0	1	0	0	0	6064	869	30	1	571	1	FRYL	4	48503750	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8381474	48503750	142650526	95	17597										
LNX1	84708	broad.mit.edu	37	chr4	54342918	54342918	+	Splice_Site	DEL	A	A	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gggatgttgtgtttggacttAccgtggtaattccagccaca							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:54342918delA	uc003hag.3	-	9	2148	c.1892_splice	c.e9+1	p.R631_splice	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Splice_Site_p.R535_splice|LNX1_uc003hah.3_Splice_Site	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a							cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GTTTGGACTTACCGTGGTAAT	0.532																		38	144	---	---								-	54342918	A	-	54342918	8	5	61	1	0	1	0	1	0	0	1	0	8865	405	14	0	304	0	LNX1	4	54342918	Splice_Site	DEL	A	TCGA-DK-A3IS-01A-21D-A21A-08	5839168	54342918	136811358	96	17598										
SRP72	6731	broad.mit.edu	37	chr4	57356772	57356772	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcacaccctggcacagcttaTttctgcttactcacttgtag	6	13	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:57356772T>A	uc003hbv.2	+	15	1503	c.1463T>A	c.(1462-1464)ATT>AAT	p.I488N	SRP72_uc010ihe.2_Missense_Mutation_p.I427N|SRP72_uc003hbw.1_Missense_Mutation_p.I249N	NM_006947	NP_008878	O76094	SRP72_HUMAN	signal recognition particle 72kDa	488					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			ovary(1)	1	Glioma(25;0.08)|all_neural(26;0.101)					GCACAGCTTATTTCTGCTTAC	0.333													0	0	0	0.005443	0	21	20										A	57356772	T	A	57356772	3	1	61	1	0	0	0	0	1	0	0	0	15156	1493	52	5	1521	5	SRP72	4	57356772	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	3013854	57356772	133797504	97	17599										
SLC4A4	8671	broad.mit.edu	37	chr4	72222830	72222830	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccggcatcaaaccaagaaatCcaaccttcggtccctggctg	8	15	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:72222830C>A	uc003hfy.2	+	6	773	c.656C>A	c.(655-657)TCC>TAC	p.S219Y	SLC4A4_uc010iic.2_Missense_Mutation_p.S219Y|SLC4A4_uc010iib.2_Missense_Mutation_p.S219Y|SLC4A4_uc003hfz.2_Missense_Mutation_p.S219Y|SLC4A4_uc003hgc.3_Missense_Mutation_p.S175Y|SLC4A4_uc003hga.2_Missense_Mutation_p.S97Y|SLC4A4_uc003hgb.3_Missense_Mutation_p.S175Y	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	219	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			ACCAAGAAATCCAACCTTCGG	0.483													1	0	8.87156e-34	0.01441	9.69773e-34	65	73										A	72222830	C	A	72222830	3	1	61	1	0	0	0	0	1	0	0	0	14656	855	30	3	795	3	SLC4A4	4	72222830	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	14866058	72222830	118931446	98	17600										
GK2	2712	broad.mit.edu	37	chr4	80328945	80328945	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaaggcctgtcttagacttgAcgaagttactatttcctgga	10	8	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:80328945A>T	uc003hlu.2	-	1	428	c.410T>A	c.(409-411)GTC>GAC	p.V137D		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	137					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						CTTAGACTTGACGAAGTTACT	0.428													0	0	0	0.00499	0	16	125										T	80328945	A	T	80328945	3	4	61	1	0	0	0	0	1	0	0	0	6421	275	10	5	1255	5	GK2	4	80328945	Missense_Mutation	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	8106115	80328945	110825331	99	17601										
FAM13A	10144	broad.mit.edu	37	chr4	89671584	89671584	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagaaacatacctcatgaaaGaatgggagtttggtggggaa	14	4	1	3	rs141057688		TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:89671584G>C	uc003hse.1	-	15	2139	c.1931C>G	c.(1930-1932)TCT>TGT	p.S644C	FAM13A_uc003hsa.1_Missense_Mutation_p.S115C|FAM13A_uc003hsb.1_Missense_Mutation_p.S318C|FAM13A_uc003hsd.1_Missense_Mutation_p.S318C|FAM13A_uc003hsc.1_Missense_Mutation_p.S304C|FAM13A_uc011cdq.1_Missense_Mutation_p.S290C|FAM13A_uc003hsf.1_Missense_Mutation_p.S230C|FAM13A_uc003hsg.1_Missense_Mutation_p.S115C|FAM13A_uc010ikr.1_Missense_Mutation_p.S140C	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	644					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						CCTCATGAAAGAATGGGAGTT	0.458													0	0	0	0.005524	0	34	58										C	89671584	G	C	89671584	3	2	61	1	0	0	0	0	1	0	0	0	5452	942	33	1	1180	1	FAM13A	4	89671584	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	9342639	89671584	101482692	100	17602										
FAM13A	10144	broad.mit.edu	37	chr4	89671699	89671699	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gctgtcttcgtccagcagctGacggatcaggcgcccagcct	12	15	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:89671699G>A	uc003hse.1	-	15	2024	c.1816C>T	c.(1816-1818)CAG>TAG	p.Q606*	FAM13A_uc003hsa.1_Nonsense_Mutation_p.Q77*|FAM13A_uc003hsb.1_Nonsense_Mutation_p.Q280*|FAM13A_uc003hsd.1_Nonsense_Mutation_p.Q280*|FAM13A_uc003hsc.1_Nonsense_Mutation_p.Q266*|FAM13A_uc011cdq.1_Nonsense_Mutation_p.Q252*|FAM13A_uc003hsf.1_Nonsense_Mutation_p.Q192*|FAM13A_uc003hsg.1_Nonsense_Mutation_p.Q77*|FAM13A_uc010ikr.1_Nonsense_Mutation_p.Q102*	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	606					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TCCAGCAGCTGACGGATCAGG	0.592													0	0	0	0.003954	0	25	46										A	89671699	G	A	89671699	4	1	61	1	0	0	0	0	0	1	0	0	5452	1299	45	1	1295	1	FAM13A	4	89671699	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	115	89671699	101482577	101	17603										
ARHGEF38	54848	broad.mit.edu	37	chr4	106510538	106510538	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagacagaaaaggattatctCaatgatctagagctgtgtgt	10	6	2	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:106510538C>G	uc003hxu.2	+	2	476	c.330C>G	c.(328-330)CTC>CTG	p.L110L		NM_017700	NP_060170	Q9NXL2	ARH38_HUMAN	hypothetical protein LOC54848	110	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|breast(1)	3						AGGATTATCTCAATGATCTAG	0.378													0	0	0	0.005524	0	29	43										G	106510538	C	G	106510538	2	3	61	1	0	0	0	0	0	0	0	1	907	813	29	1		1	ARHGEF38	4	106510538	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	16838839	106510538	84643738	102	17604										
INTS12	57117	broad.mit.edu	37	chr4	106603932	106603932	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcagctttcttcttgaccatCtgtaatcgcttcatagcatt	6	11	4	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:106603932C>T	uc003hxw.2	-	8	1605	c.1347G>A	c.(1345-1347)CAG>CAA	p.Q449Q	INTS12_uc010ilr.2_Silent_p.Q449Q	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	449					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TCTTGACCATCTGTAATCGCT	0.408													0	0	0	0.01441	0	67	110										T	106603932	C	T	106603932	2	4	61	1	0	0	0	0	0	0	0	1	7777	912	32	1		1	INTS12	4	106603932	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	93394	106603932	84550344	103	17605										
KIAA1109	84162	broad.mit.edu	37	chr4	123141550	123141550	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaaagactatgttttgaaatGaaaaaaggatttagggagac	11	2	0	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:123141550G>C	uc003ieh.2	+	20	2583	c.2538G>C	c.(2536-2538)ATG>ATC	p.M846I	KIAA1109_uc003iei.1_Missense_Mutation_p.M600I|KIAA1109_uc010ins.1_Missense_Mutation_p.M190I|KIAA1109_uc003iej.1_Missense_Mutation_p.M231I	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	846					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTTTTGAAATGAAAAAAGGAT	0.393													0	0	0	0.014323	0	19	19										C	123141550	G	C	123141550	3	2	61	1	0	0	0	0	1	0	0	0	8208	1290	45	1	2616	1	KIAA1109	4	123141550	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	16537618	123141550	68012726	104	17606										
KIAA1109	84162	broad.mit.edu	37	chr4	123159417	123159417	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cacagcctttgttggctggtGaaaaggaaagtccttcatct	10	9	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:123159417G>A	uc003ieh.2	+	26	3790	c.3745G>A	c.(3745-3747)GAA>AAA	p.E1249K	KIAA1109_uc003iei.1_Missense_Mutation_p.E1002K|KIAA1109_uc010ins.1_Missense_Mutation_p.E592K|KIAA1109_uc003iek.2_5'Flank	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1249					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTTGGCTGGTGAAAAGGAAAG	0.433													0	0	0	0.005524	0	34	33										A	123159417	G	A	123159417	3	1	61	1	0	0	0	0	1	0	0	0	8208	1291	45	1	3847	1	KIAA1109	4	123159417	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	17867	123159417	67994859	105	17607										
TTC29	83894	broad.mit.edu	37	chr4	147754965	147754965	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtgctaacttacctctgcaGgaccttggctatggcttcat	9	11	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:147754965G>A	uc003ikw.3	-	9	1197	c.970C>T	c.(970-972)CTG>TTG	p.L324L	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Silent_p.L350L|TTC29_uc010ipd.1_Silent_p.L324L	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	324	TPR 4.						binding				0	all_hematologic(180;0.151)					TACCTCTGCAGGACCTTGGCT	0.448													0	0	0	0.005524	0	29	32										A	147754965	G	A	147754965	2	1	61	1	0	0	0	0	0	0	0	1	16693	991	35	2		2	TTC29	4	147754965	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	24595548	147754965	43399311	106	17608										
CCDC111	201973	broad.mit.edu	37	chr4	185606792	185606792	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttatgatatttgtaaatatCggtggtgtgaaaacattgga	10	2	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr4:185606792C>T	uc003iwk.2	+	11	1682	c.1249C>T	c.(1249-1251)CGG>TGG	p.R417W	CCDC111_uc003iwj.2_Missense_Mutation_p.R416W|CCDC111_uc003iwl.2_Missense_Mutation_p.R417W|CCDC111_uc003iwm.2_Missense_Mutation_p.R288W|CCDC111_uc003iwn.2_Missense_Mutation_p.R157W	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	417					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		TTGTAAATATCGGTGGTGTGA	0.279													0	0	0	0.01441	0	44	37										T	185606792	C	T	185606792	3	4	61	1	0	0	0	0	1	0	0	0	2748	875	31	1	1283	1	CCDC111	4	185606792	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	37851827	185606792	5547484	107	17609										
FAM105B	90268	broad.mit.edu	37	chr5	14690313	14690313	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aagagaaaggaaaggaagtaCcatttttctctgtgcttctg	10	6	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:14690313C>T	uc003jfk.2	+	6	912	c.760C>T	c.(760-762)CCA>TCA	p.P254S		NM_138348	NP_612357	Q96BN8	F105B_HUMAN	hypothetical protein LOC90268	254										ovary(2)	2	Lung NSC(4;0.00696)					AAAGGAAGTACCATTTTTCTC	0.428													0	0	0	0.007291	0	28	20										T	14690313	C	T	14690313	3	4	61	1	0	0	0	0	1	0	0	0	5388	507	18	2	782	2	FAM105B	5	14690313	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		14690313	166224947	108	17610										
ZNF622	90441	broad.mit.edu	37	chr5	16453158	16453158	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcccagggctctgtactgctGaagtactcggcccacggcct	11	15	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:16453158G>A	uc003jfq.2	-	5	1390	c.1270C>T	c.(1270-1272)CAG>TAG	p.Q424*		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	424						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						CTGTACTGCTGAAGTACTCGG	0.502													0	0	0	0.012319	0	18	39										A	16453158	G	A	16453158	4	1	61	1	0	0	0	0	0	1	0	0	18043	1299	45	1	171	1	ZNF622	5	16453158	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1762845	16453158	164462102	109	17611										
ZFR	51663	broad.mit.edu	37	chr5	32364311	32364311	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaatgcattcaaaaactcttCtcagtgcatccccagggctc	6	13	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:32364311C>G	uc003jhr.1	-	18	2986	c.2906G>C	c.(2905-2907)AGA>ACA	p.R969T	ZFR_uc010ium.1_Missense_Mutation_p.R100T|ZFR_uc011cny.1_RNA	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	969	DZF.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		AAAAACTCTTCTCAGTGCATC	0.353													0	0	0	0.01441	0	51	45										G	32364311	C	G	32364311	3	3	61	1	0	0	0	0	1	0	0	0	17656	913	32	1	330	1	ZFR	5	32364311	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	15911153	32364311	148550949	110	17612										
ADAMTS12	81792	broad.mit.edu	37	chr5	33751570	33751570	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcctcctgtaaacgatgtgCgggtggtaccctccctcaac	10	14	1	0	rs143045075		TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:33751570C>T	uc003jia.1	-	3	736	c.573G>A	c.(571-573)CCG>CCA	p.P191P	ADAMTS12_uc010iuq.1_Silent_p.P191P|ADAMTS12_uc003jib.1_Silent_p.P191P	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	191					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AAACGATGTGCGGGTGGTACC	0.463										HNSCC(64;0.19)			0	0	0	0.008361	0	26	70										T	33751570	C	T	33751570	2	4	61	1	0	0	0	0	0	0	0	1	257	755	27	2		2	ADAMTS12	5	33751570	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1387259	33751570	147163690	111	17613										
C9	735	broad.mit.edu	37	chr5	39311467	39311467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aatttctcctttcacatgcaGaaacattttttcctgtgttg	5	9	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:39311467G>C	uc003jlv.3	-	7	972	c.883C>G	c.(883-885)CTG>GTG	p.L295V		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	295	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TTCACATGCAGAAACATTTTT	0.348													0	0	0	0.010818	0	27	15										C	39311467	G	C	39311467	3	2	61	1	0	0	0	0	1	0	0	0	2443	933	33	1	816	1	C9	5	39311467	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5559897	39311467	141603793	112	17614										
IL31RA	133396	broad.mit.edu	37	chr5	55178999	55178999	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttaaaatacacacttcgattCaggacagtcaacagtaccag	6	10	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:55178999C>T	uc003jql.2	+	5	647	c.582C>T	c.(580-582)TTC>TTT	p.F194F	IL31RA_uc003jqk.2_Silent_p.F194F|IL31RA_uc011cqj.1_Silent_p.F52F|IL31RA_uc003jqm.2_Silent_p.F162F|IL31RA_uc003jqn.2_Silent_p.F194F|IL31RA_uc010iwa.1_Silent_p.F162F|IL31RA_uc003jqo.2_Silent_p.F52F	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	162	Extracellular (Potential).|Fibronectin type-III 2.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CACTTCGATTCAGGACAGTCA	0.388													0	0	0	0.00623	0	31	13										T	55178999	C	T	55178999	2	4	61	1	0	0	0	0	0	0	0	1	7691	825	29	1		1	IL31RA	5	55178999	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	15867532	55178999	125736261	113	17615										
SGTB	54557	broad.mit.edu	37	chr5	64967757	64967757	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cttacgcttggatgaggcttGacaggtcagttaggccccca	12	11	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:64967757G>C	uc003jud.2	-	10	1008	c.788C>G	c.(787-789)TCA>TGA	p.S263*		NM_019072	NP_061945	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat	263							binding				0		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		GATGAGGCTTGACAGGTCAGT	0.423													0	0	0	0.007413	0	16	19										C	64967757	G	C	64967757	4	2	61	1	0	0	0	0	0	1	0	0	14226	1294	45	1	134	1	SGTB	5	64967757	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	9788758	64967757	115947503	114	17616										
MSH3	4437	broad.mit.edu	37	chr5	80063775	80063775	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctacccaagagttcttcttGattgtcaaaactttatatca	4	9	5	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:80063775G>C	uc003kgz.2	+	14	2173	c.1920G>C	c.(1918-1920)TTG>TTC	p.L640F		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	640					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		AGTTCTTCTTGATTGTCAAAA	0.303								MMR					0	0	0	0.008291	0	8	27										C	80063775	G	C	80063775	3	2	61	1	0	0	0	0	1	0	0	0	9871	1281	45	1	1974	1	MSH3	5	80063775	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	15096018	80063775	100851485	115	17617										
RHOBTB3	22836	broad.mit.edu	37	chr5	95067591	95067591	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acatcgtggcgctggggaacGagggggacacattccaccag	15	11	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:95067591G>A	uc003klm.2	+	2	568	c.31G>A	c.(31-33)GAG>AAG	p.E11K	RHOBTB3_uc003klk.1_5'UTR|RHOBTB3_uc003kll.2_Missense_Mutation_p.E11K	NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	11	Rho-like.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		GCTGGGGAACGAGGGGGACAC	0.652													0	0	0	0.005443	0	18	42										A	95067591	G	A	95067591	3	1	61	1	0	0	0	0	1	0	0	0	13335	1059	37	1	37	1	RHOBTB3	5	95067591	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	15003816	95067591	85847669	116	17618										
RHOBTB3	22836	broad.mit.edu	37	chr5	95067677	95067677	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctctggtctccggggacgaGagcagcttgttgctgaacgc	14	12	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:95067677G>C	uc003klm.2	+	2	654	c.117G>C	c.(115-117)GAG>GAC	p.E39D	RHOBTB3_uc003klk.1_5'UTR|RHOBTB3_uc003kll.2_Missense_Mutation_p.E39D	NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	39	Rho-like.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		CCGGGGACGAGAGCAGCTTGT	0.637													0	0	0	0.012319	0	18	42										C	95067677	G	C	95067677	3	2	61	1	0	0	0	0	1	0	0	0	13335	933	33	1	123	1	RHOBTB3	5	95067677	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	86	95067677	85847583	117	17619										
SNCAIP	9627	broad.mit.edu	37	chr5	121759135	121759135	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agcacaagctgtccactgaaGaaaccgagatctcacctcct	7	14	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:121759135G>A	uc003ksw.1	+	4	909	c.703G>A	c.(703-705)GAA>AAA	p.E235K	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.E235K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E282K|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.E235K	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	235					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GTCCACTGAAGAAACCGAGAT	0.458													0	0	0	0.00333	0	23	39										A	121759135	G	A	121759135	3	1	61	1	0	0	0	0	1	0	0	0	14841	943	33	1	713	1	SNCAIP	5	121759135	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	26691458	121759135	59156125	118	17620										
PPIC	5480	broad.mit.edu	37	chr5	122364492	122364492	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccagtgccatctccagtggtGatgtcacctccttgaatcat	8	13	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:122364492G>A	uc003kth.2	-	3	408	c.303C>T	c.(301-303)ATC>ATT	p.I101I	PPIC_uc011cwp.1_3'UTR	NM_000943	NP_000934	P45877	PPIC_HUMAN	peptidylprolyl isomerase C	101	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			ovary(1)	1		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	CTCCAGTGGTGATGTCACCTC	0.393													0	0	0	0.003163	0	13	28										A	122364492	G	A	122364492	2	1	61	1	0	0	0	0	0	0	0	1	12320	1280	45	1		1	PPIC	5	122364492	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	605357	122364492	58550768	119	17621										
FNIP1	96459	broad.mit.edu	37	chr5	131046318	131046318	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcggagcggaccctgctcaGagaatgcccgcctggggctg	17	13	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:131046318G>C	uc003kvs.1	-	7	801	c.659C>G	c.(658-660)TCT>TGT	p.S220C	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Intron|FNIP1_uc010jdm.1_Missense_Mutation_p.S175C|FNIP1_uc003kvu.2_Missense_Mutation_p.S220C	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	220					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ACCCTGCTCAGAGAATGCCCG	0.527													0	0	0	0.006122	0	14	12										C	131046318	G	C	131046318	3	2	61	1	0	0	0	0	1	0	0	0	5975	942	33	1	2889	1	FNIP1	5	131046318	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	8681826	131046318	49868942	120	17622										
PCDHA8	56140	broad.mit.edu	37	chr5	140222358	140222358	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctgcgcgagacgcggacgcGcaggagaacgcgctggtgtc	17	12	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:140222358G>A	uc003lhs.2	+	1	1452	c.1452G>A	c.(1450-1452)GCG>GCA	p.A484A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.A484A	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	484	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCGGACGCGCAGGAGAACG	0.657													0	0	0	0.01441	0	44	69										A	140222358	G	A	140222358	2	1	61	1	0	0	0	0	0	0	0	1	11530	1074	38	2		2	PCDHA8	5	140222358	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	9176040	140222358	40692902	121	17623										
KIAA0141	9812	broad.mit.edu	37	chr5	141314121	141314121	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctggatgagcagagagctgtGaaatatctttggcttgcagc	13	7	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:141314121G>A	uc003lls.2	+	10	1241	c.1119G>A	c.(1117-1119)GTG>GTA	p.V373V	KIAA0141_uc003llt.2_Silent_p.V373V|KIAA0141_uc003llu.1_RNA	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor	373	TPR 5.				apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGAGCTGTGAAATATCTTT	0.507													0	0	0	0.01441	0	65	31										A	141314121	G	A	141314121	2	1	61	1	0	0	0	0	0	0	0	1	8156	1277	45	1		1	KIAA0141	5	141314121	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1091763	141314121	39601139	122	17624										
ARHGEF37	389337	broad.mit.edu	37	chr5	148999931	148999931	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtccaggctttcctctacttCaggccgcacgaatacaatct	7	14	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:148999931C>T	uc003lra.1	+	8	973	c.909C>T	c.(907-909)TTC>TTT	p.F303F		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	303	BAR.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						TCCTCTACTTCAGGCCGCACG	0.408													0	0	0	0.010818	0	21	94										T	148999931	C	T	148999931	2	4	61	1	0	0	0	0	0	0	0	1	906	825	29	1		1	ARHGEF37	5	148999931	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	7685810	148999931	31915329	123	17625										
PDGFRB	5159	broad.mit.edu	37	chr5	149498309	149498309	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccctaccctgcctcaacataCctttttgtaaccttcgccca	3	18	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:149498309C>A	uc003lro.2	-	21	3373	c.2904_splice	c.e21+1	p.K968_splice	PDGFRB_uc010jhd.2_Splice_Site_p.K807_splice	NM_002609	NP_002600	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor beta						aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTCAACATACCTTTTTGTAA	0.557			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								1	0	8.72158e-25	0.01441	9.44998e-25	49	33										A	149498309	C	A	149498309	5	1	61	1	0	0	0	0	0	0	1	0	11662	521	18	4	427	4	PDGFRB	5	149498309	Splice_Site	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	498378	149498309	31416951	124	17626										
FAT2	2196	broad.mit.edu	37	chr5	150935954	150935954	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtccagctgctgggctgtaGataggagacctgagagagag	16	7	0	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:150935954G>C	uc003lue.3	-	3	3597	c.3584C>G	c.(3583-3585)TCT>TGT	p.S1195C	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.S1195C	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1195	Extracellular (Potential).|Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGGGCTGTAGATAGGAGACC	0.458													0	0	0	0.00632	0	23	32										C	150935954	G	C	150935954	3	2	61	1	0	0	0	0	1	0	0	0	5690	942	33	1	9549	1	FAT2	5	150935954	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1437645	150935954	29979306	125	17627										
ATP6V0E1	8992	broad.mit.edu	37	chr5	172410891	172410891	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atcacggcctcactgtgcctCtcattgtgatgagcgtgttc	10	12	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr5:172410891C>G	uc003mcd.1	+	1	129	c.28C>G	c.(28-30)CTC>GTC	p.L10V		NM_003945	NP_003936	O15342	VA0E1_HUMAN	ATPase, H+ transporting, lysosomal 9kDa, V0	10	Helical; (Potential).				ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|membrane fraction|proton-transporting V-type ATPase, V0 domain|vacuole	proton-transporting ATPase activity, rotational mechanism				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CACTGTGCCTCTCATTGTGAT	0.617													0	0	0	0.01441	0	91	180										G	172410891	C	G	172410891	3	3	61	1	0	0	0	0	1	0	0	0	1175	913	32	1	30	1	ATP6V0E1	5	172410891	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	21474937	172410891	8504369	126	17628										
HIST1H3D	8351	broad.mit.edu	37	chr6	26197163	26197163	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcgcataggttggtgtcctCaaacagccccaccaggtagg	13	12	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:26197163C>T	uc003ngv.2	-	2	713	c.316G>A	c.(316-318)GAG>AAG	p.E106K	HIST1H2BF_uc003ngx.2_5'Flank	NM_003530	NP_003521	P68431	H31_HUMAN	histone cluster 1, H3d	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				TTGGTGTCCTCAAACAGCCCC	0.592													0	0	0	0.01441	0	61	67										T	26197163	C	T	26197163	3	4	61	1	0	0	0	0	1	0	0	0	7158	835	29	1	98	1	HIST1H3D	6	26197163	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		26197163	144917904	127	17629										
C6orf27	80737	broad.mit.edu	37	chr6	31735166	31735166	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctcaccccaggggtgtcctCagctgtgacctggatctccc	10	16	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:31735166C>T	uc011dog.1	-	12	2000	c.1762G>A	c.(1762-1764)GAG>AAG	p.E588K	C6orf27_uc003nxd.2_Missense_Mutation_p.E263K	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	588						extracellular region				ovary(3)	3						GGGGTGTCCTCAGCTGTGACC	0.592													0	0	0	0.01441	0	36	53										T	31735166	C	T	31735166	3	4	61	1	0	0	0	0	1	0	0	0	2362	835	29	1	936	1	C6orf27	6	31735166	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5538003	31735166	139379901	128	17630										
BTNL2	56244	broad.mit.edu	37	chr6	32362585	32362585	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atgctgatggaacaagtgacGtccacagcggagatgtttgt	13	7	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:32362585G>A	uc003obg.1	-	6	1296	c.1296C>T	c.(1294-1296)GAC>GAT	p.D432D	BTNL2_uc010jty.1_Silent_p.D155D|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Silent_p.D222D	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	432	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						AACAAGTGACGTCCACAGCGG	0.498													0	0	0	0.00245	0	11	140										A	32362585	G	A	32362585	2	1	61	1	0	0	0	0	0	0	0	1	1565	1136	40	2		2	BTNL2	6	32362585	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	627419	32362585	138752482	129	17631										
TAP1	6890	broad.mit.edu	37	chr6	32821186	32821186	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttggagccaaccgttgccctGaggaccccgcaggcccccag	12	17	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:32821186G>A	uc003ocg.2	-	1	563	c.408C>T	c.(406-408)CTC>CTT	p.L136L	TAP1_uc011dqi.1_5'Flank|PSMB9_uc011dqj.1_5'Flank|PSMB9_uc003sga.2_5'Flank	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	136	Helical; Name=2; (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						CCGTTGCCCTGAGGACCCCGC	0.697													0	0	0	0.001168	0	5	10										A	32821186	G	A	32821186	2	1	61	1	0	0	0	0	0	0	0	1	15547	1277	45	1		1	TAP1	6	32821186	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	458601	32821186	138293881	130	17632										
PACSIN1	29993	broad.mit.edu	37	chr6	34499551	34499551	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggccaggagcaggacgagctCagctttaaggccggtaggac	16	10	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:34499551C>G	uc003ojo.2	+	9	1418	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L	PACSIN1_uc003ojp.2_Silent_p.L404L	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	404	SH3.				endocytosis		protein kinase activity				0						AGGACGAGCTCAGCTTTAAGG	0.652													0	0	0	0.01441	0	46	67										G	34499551	C	G	34499551	2	3	61	1	0	0	0	0	0	0	0	1	11374	813	29	1		1	PACSIN1	6	34499551	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1678365	34499551	136615516	131	17633										
NFKBIE	4794	broad.mit.edu	37	chr6	44233167	44233167	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgcctttccgggttgcgggtCcgcttggcagagcgggcgcc	17	14	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:44233167C>G	uc003oxe.1	-	1	359	c.334G>C	c.(334-336)GAC>CAC	p.D112H		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	112					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGTTGCGGGTCCGCTTGGCAG	0.667													0	0	0	0.004672	0	2	4										G	44233167	C	G	44233167	3	3	61	1	0	0	0	0	1	0	0	0	10380	855	30	1	1192	1	NFKBIE	6	44233167	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	9733616	44233167	126881900	132	17634			2	74		3	3	107	C		1.023396e-06
NFKBIE	4794	broad.mit.edu	37	chr6	44233256	44233256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgcgcagcgaggacaaggttCggagcgctggccaggtccac	16	13	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:44233256C>T	uc003oxe.1	-	1	270	c.245G>A	c.(244-246)CGA>CAA	p.R82Q		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	82					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGACAAGGTTCGGAGCGCTGG	0.642													0	0	0	0.009096	0	3	5										T	44233256	C	T	44233256	3	4	61	1	0	0	0	0	1	0	0	0	10380	884	31	1	1281	1	NFKBIE	6	44233256	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	89	44233256	126881811	133	17635			2	74		3	3	107	C		1.023396e-06
NFKBIE	4794	broad.mit.edu	37	chr6	44233273	44233273	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gttcggagcgctggccaggtCcacccagcggttactgtggg	16	12	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:44233273C>T	uc003oxe.1	-	1	253	c.228G>A	c.(226-228)TGG>TGA	p.W76*		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	76					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGGCCAGGTCCACCCAGCGG	0.612													0	0	0	0.009096	0	3	6										T	44233273	C	T	44233273	4	4	61	1	0	0	0	0	0	1	0	0	10380	856	30	1	1298	1	NFKBIE	6	44233273	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	17	44233273	126881794	134	17636			2	74		3	3	107	C		1.023396e-06
FAM83B	222584	broad.mit.edu	37	chr6	54735420	54735420	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cccatatagatctcctttttCatccaccaagagcacatcta	3	14	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:54735420C>A	uc003pck.2	+	2	492	c.376C>A	c.(376-378)CAT>AAT	p.H126N		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	126										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TCTCCTTTTTCATCCACCAAG	0.398													1	0	5.03518e-11	0.007413	5.28159e-11	16	35										A	54735420	C	A	54735420	3	1	61	1	0	0	0	0	1	0	0	0	5634	826	29	3	378	3	FAM83B	6	54735420	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	10502147	54735420	116379647	135	17637										
IMPG1	3617	broad.mit.edu	37	chr6	76734920	76734920	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctaagcttacctgttgaaaTgacaatggtttcaccaggct	8	9	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:76734920T>A	uc003pik.1	-	5	683	c.553A>T	c.(553-555)ATT>TTT	p.I185F		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	185					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCTGTTGAAATGACAATGGTT	0.323													0	0	0	0.007413	0	15	49										A	76734920	T	A	76734920	3	1	61	1	0	0	0	0	1	0	0	0	7728	1464	51	5	1892	5	IMPG1	6	76734920	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	21999500	76734920	94380147	136	17638										
KIAA1009	22832	broad.mit.edu	37	chr6	84872884	84872884	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtgacataagcaatctgatCtttggcttggtccctctctt	8	10	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:84872884C>T	uc010kbp.2	-	19	2588	c.2491G>A	c.(2491-2493)GAT>AAT	p.D831N	KIAA1009_uc003pkj.3_Missense_Mutation_p.D755N|KIAA1009_uc003pki.3_Missense_Mutation_p.D217N	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	831	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		GCAATCTGATCTTTGGCTTGG	0.333													0	0	0	0.007291	0	25	79										T	84872884	C	T	84872884	3	4	61	1	0	0	0	0	1	0	0	0	8203	913	32	1	1756	1	KIAA1009	6	84872884	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8137964	84872884	86242183	137	17639										
RFPL4B	442247	broad.mit.edu	37	chr6	112671645	112671645	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagcttttgtgtccattcttCtgtcttgagctcttgggaga	11	8	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:112671645C>G	uc003pvx.1	+	3	1047	c.735C>G	c.(733-735)TTC>TTG	p.F245L		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	245	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		GTCCATTCTTCTGTCTTGAGC	0.438													0	0	0	0.003755	0	28	19										G	112671645	C	G	112671645	3	3	61	1	0	0	0	0	1	0	0	0	13256	912	32	1	737	1	RFPL4B	6	112671645	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	27798761	112671645	58443422	138	17640										
TAAR5	9038	broad.mit.edu	37	chr6	132909813	132909813	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgcatttagtagaaggaatCattcttggtacaaatcaaca	7	7	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:132909813C>G	uc003qdk.2	-	1	1065	c.1013G>C	c.(1012-1014)TGA>TCA	p.*338S		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	338					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		TAGAAGGAATCATTCTTGGTA	0.488													0	0	0	0.009718	0	32	27										G	132909813	C	G	132909813	4	3	61	1	0	0	0	0	0	0	0	0	15488	837	29	1	4	1	TAAR5	6	132909813	Nonstop_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	20238168	132909813	38205254	139	17641										
FBXO30	84085	broad.mit.edu	37	chr6	146127103	146127103	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctaggtttggatactttatCagttgcttttgacatcatgg	9	6	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:146127103C>T	uc003qla.2	-	2	638	c.439G>A	c.(439-441)GAT>AAT	p.D147N	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	147							ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GATACTTTATCAGTTGCTTTT	0.403													0	0	0	0.01441	0	53	36										T	146127103	C	T	146127103	3	4	61	1	0	0	0	0	1	0	0	0	5740	826	29	1	1806	1	FBXO30	6	146127103	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	13217290	146127103	24987964	140	17642										
RAET1E	135250	broad.mit.edu	37	chr6	150209697	150209697	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttttgccaccagacacagatGagaacaattcccattaaaac	5	11	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:150209697G>A	uc003qnl.1	-	4	789	c.729C>T	c.(727-729)CTC>CTT	p.L243L	uc003qni.1_Intron|RAET1E_uc003qnj.2_Intron|RAET1E_uc003qnk.1_Silent_p.L207L|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	243	Helical; (Potential).				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		AGACACAGATGAGAACAATTC	0.473													0	0	0	0.00874	0	34	71										A	150209697	G	A	150209697	2	1	61	1	0	0	0	0	0	0	0	1	12999	1277	45	1		1	RAET1E	6	150209697	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4082594	150209697	20905370	141	17643										
RAET1E	135250	broad.mit.edu	37	chr6	150210554	150210554	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgatcgcagtctccctttgaGagcttcctgaaatacttttc	7	11	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:150210554G>C	uc003qnl.1	-	3	612	c.552C>G	c.(550-552)CTC>CTG	p.L184L	uc003qni.1_Intron|RAET1E_uc003qnj.2_Silent_p.L184L|RAET1E_uc003qnk.1_Silent_p.L148L|RAET1E_uc010kih.1_RNA	NM_139165	NP_631904	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E precursor	184	Extracellular (Potential).|MHC class I alpha-2 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		CTCCCTTTGAGAGCTTCCTGA	0.493													0	0	0	0.005443	0	24	42										C	150210554	G	C	150210554	2	2	61	1	0	0	0	0	0	0	0	1	12999	929	33	1		1	RAET1E	6	150210554	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	857	150210554	20904513	142	17644										
SYNJ2	8871	broad.mit.edu	37	chr6	158449892	158449892	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgccactgacttttaccctCttcaggaagaggccaaggag	10	12	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr6:158449892C>T	uc003qqx.1	+	3	394	c.319C>T	c.(319-321)CTT>TTT	p.L107F	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.L107F|SYNJ2_uc003qqy.1_5'UTR|SYNJ2_uc011efn.1_Missense_Mutation_p.L56F|SYNJ2_uc010kjo.1_Missense_Mutation_p.L56F	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	107							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CTTTTACCCTCTTCAGGAAGA	0.502													0	0	0	0.007291	0	23	16										T	158449892	C	T	158449892	3	4	61	1	0	0	0	0	1	0	0	0	15450	913	32	1	329	1	SYNJ2	6	158449892	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8239338	158449892	12665175	143	17645										
RSPH10B2	728194	broad.mit.edu	37	chr7	5967926	5967926	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccttgatagcttcttcacgtTtatacgcatgaaagagcgtg	9	9	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:5967926T>C	uc003sph.1	-	20	2604	c.2333A>G	c.(2332-2334)AAA>AGA	p.K778R	RSPH10B2_uc003spg.1_Intron|RSPH10B2_uc010ktd.1_Missense_Mutation_p.K778R|RSPH10B2_uc011jwk.1_3'UTR	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	778										ovary(1)|pancreas(1)|skin(1)	3						TTCTTCACGTTTATACGCATG	0.463													0	0	0	0.01441	0	28	177										C	5967926	T	C	5967926	3	2	61	1	0	0	0	0	1	0	0	0	13704	1841	64	5	287	5	RSPH10B2	7	5967926	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08		5967926	153170737	144	17646										
CDCA7L	55536	broad.mit.edu	37	chr7	21947797	21947797	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tccttttcagcaaagcatctGaactctcctggctctcatcc	5	15	4	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:21947797G>A	uc010kuk.2	-	4	752	c.632C>T	c.(631-633)TCA>TTA	p.S211L	CDCA7L_uc003sve.3_Missense_Mutation_p.S177L|CDCA7L_uc010kul.2_Missense_Mutation_p.S165L|CDCA7L_uc003svf.3_Missense_Mutation_p.S210L|CDCA7L_uc011jyk.1_Missense_Mutation_p.S211L	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	211					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						CAAAGCATCTGAACTCTCCTG	0.498													0	0	0	0.008291	0	10	10										A	21947797	G	A	21947797	3	1	61	1	0	0	0	0	1	0	0	0	3091	1294	45	1	760	1	CDCA7L	7	21947797	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	15979871	21947797	137190866	145	17647										
URGCP	55665	broad.mit.edu	37	chr7	43916794	43916794	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gacgtcaaggccccacctatCaagcccccggagtctatcac	8	17	4	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:43916794C>G	uc003tiw.2	-	6	2325	c.2268G>C	c.(2266-2268)TTG>TTC	p.L756F	URGCP_uc003tiu.2_Missense_Mutation_p.L713F|URGCP_uc003tiv.2_Missense_Mutation_p.L681F|URGCP_uc003tix.2_Missense_Mutation_p.L747F|URGCP_uc003tiy.2_Missense_Mutation_p.L713F|URGCP_uc003tiz.2_Missense_Mutation_p.L713F|URGCP_uc011kbj.1_Missense_Mutation_p.L713F	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	756					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CCCCACCTATCAAGCCCCCGG	0.597													0	0	0	0.012319	0	19	21										G	43916794	C	G	43916794	3	3	61	1	0	0	0	0	1	0	0	0	17023	825	29	1	531	1	URGCP	7	43916794	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	21968997	43916794	115221869	146	17648										
OGDH	4967	broad.mit.edu	37	chr7	44664045	44664045	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagcagcagctaggacatttCaacagattcggtgctattct	9	10	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:44664045C>T	uc003tln.2	+	2	212	c.103C>T	c.(103-105)CAA>TAA	p.Q35*	OGDH_uc003tlm.2_Nonsense_Mutation_p.Q35*|OGDH_uc011kbx.1_Nonsense_Mutation_p.Q35*|OGDH_uc011kby.1_Nonsense_Mutation_p.Q35*|OGDH_uc003tlp.2_Nonsense_Mutation_p.Q35*|OGDH_uc011kbz.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	35					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TAGGACATTTCAACAGATTCG	0.468													0	0	0	0.01441	0	101	124										T	44664045	C	T	44664045	4	4	61	1	0	0	0	0	0	1	0	0	10839	827	29	1	105	1	OGDH	7	44664045	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	747251	44664045	114474618	147	17649										
TNS3	64759	broad.mit.edu	37	chr7	47454805	47454805	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cactgaggaactgaacatacCtgcaaaacggacagctgggt	11	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:47454805C>T	uc003tnv.2	-	11	841	c.474_splice	c.e11-1	p.R158_splice	TNS3_uc003tnw.2_Splice_Site_p.R158_splice|TNS3_uc010kyo.1_Splice_Site_p.R158_splice	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3							focal adhesion	protein binding			ovary(4)	4						CTGAACATACCTGCAAAACGG	0.537													0	0	0	0.003163	0	13	16										T	47454805	C	T	47454805	5	4	61	1	0	0	0	0	0	0	1	0	16341	695	24	2	3948	2	TNS3	7	47454805	Splice_Site	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2790760	47454805	111683858	148	17650										
ELN	2006	broad.mit.edu	37	chr7	73477649	73477651	+	In_Frame_Del	DEL	CCG	CCG	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtgttcccaggagccggacCcgccgccgccgctgccgcag							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:73477649_73477651delCCG	uc003tzw.2	+	28	1977_1979	c.1886_1888delCCG	c.(1885-1890)CCCGCC>CCC	p.A636del	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_In_Frame_Del_p.A630del|ELN_uc003tzz.2_In_Frame_Del_p.A549del|ELN_uc003tzo.2_In_Frame_Del_p.A582del|ELN_uc003tzp.2_In_Frame_Del_p.A541del|ELN_uc003tzq.2_In_Frame_Del_p.A494del|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_In_Frame_Del_p.A611del|ELN_uc003tzt.2_In_Frame_Del_p.A635del|ELN_uc003tzu.2_In_Frame_Del_p.A616del|ELN_uc003tzv.2_In_Frame_Del_p.A601del|ELN_uc003tzx.2_In_Frame_Del_p.A620del|ELN_uc011kff.1_In_Frame_Del_p.A630del|ELN_uc003tzy.2_In_Frame_Del_p.A606del	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	692	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GGAGCCGGACccgccgccgccgc	0.512			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome											2	4	---	---								-	73477651	CCG	-	73477649	7	5	61	1	0	1	0	1	0	0	0	0	5071	623	22	0	1993	0	ELN	7	73477649	In_Frame_Del	DEL	CCG	TCGA-DK-A3IS-01A-21D-A21A-08	26022844	73477649	85661014	149	17651										
PION	54103	broad.mit.edu	37	chr7	77011907	77011907	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttacatttctcttctgaaatCagtaacagatggttctctgg	7	8	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:77011907C>T	uc003ugf.2	-	7	589	c.510G>A	c.(508-510)CTG>CTA	p.L170L	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	170					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CTTCTGAAATCAGTAACAGAT	0.343													0	0	0	0.007413	0	13	31										T	77011907	C	T	77011907	2	4	61	1	0	0	0	0	0	0	0	1	11934	813	29	1		1	PION	7	77011907	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3534258	77011907	82126756	150	17652										
MAGI2	9863	broad.mit.edu	37	chr7	77649030	77649030	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctcctcgagcctcggccgcgCggccctctgcggactcgccg	13	20	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:77649030C>T	uc003ugx.2	-	22	4224	c.3970G>A	c.(3970-3972)GCG>ACG	p.A1324T	MAGI2_uc003ugy.2_Missense_Mutation_p.A1310T	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	1324						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTCGGCCGCGCGGCCCTCTGC	0.403													0	0	0	0.009096	0	4	4										T	77649030	C	T	77649030	3	4	61	1	0	0	0	0	1	0	0	0	9191	768	27	2	401	2	MAGI2	7	77649030	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	637123	77649030	81489633	151	17653										
DBF4	10926	broad.mit.edu	37	chr7	87529618	87529618	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agccctgcagtccatttgatGtagacaagccatctagtatg	9	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:87529618G>A	uc003ujf.1	+	9	1267	c.763G>A	c.(763-765)GTA>ATA	p.V255I	DBF4_uc003ujh.1_5'UTR|DBF4_uc003ujg.1_Missense_Mutation_p.V31I|DBF4_uc011khf.1_Missense_Mutation_p.V22I	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	255					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TCCATTTGATGTAGACAAGCC	0.323													0	0	0	0.010818	0	26	28										A	87529618	G	A	87529618	3	1	61	1	0	0	0	0	1	0	0	0	4248	1377	48	2	797	2	DBF4	7	87529618	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	9880588	87529618	71609045	152	17654										
AKAP9	10142	broad.mit.edu	37	chr7	91736731	91736731	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aggtcccctttaccatttcaGaataggtaagaatatgagaa	8	7	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:91736731G>C	uc003ulg.2	+	48	11766	c.11541G>C	c.(11539-11541)CAG>CAC	p.Q3847H	AKAP9_uc003ulf.2_Missense_Mutation_p.Q3839H|AKAP9_uc003uli.2_Missense_Mutation_p.Q3470H|AKAP9_uc003ulj.2_Missense_Mutation_p.Q1617H|AKAP9_uc003ull.2_Missense_Mutation_p.Q743H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3851					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TACCATTTCAGAATAGGTAAG	0.363			T	BRAF	papillary thyroid								0	0	0	0.008361	0	24	19										C	91736731	G	C	91736731	3	2	61	1	0	0	0	0	1	0	0	0	459	933	33	1	11731	1	AKAP9	7	91736731	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4207113	91736731	67401932	153	17655										
LMTK2	22853	broad.mit.edu	37	chr7	97822019	97822019	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acataaatgatcttcagacaGaacttaagaatgctggtttt	7	6	2	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:97822019G>C	uc003upd.1	+	11	2535	c.2242G>C	c.(2242-2244)GAA>CAA	p.E748Q		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	748					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TCTTCAGACAGAACTTAAGAA	0.343													0	0	0	0.006122	0	17	12										C	97822019	G	C	97822019	3	2	61	1	0	0	0	0	1	0	0	0	8859	943	33	1	2284	1	LMTK2	7	97822019	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6085288	97822019	61316644	154	17656										
MEPCE	56257	broad.mit.edu	37	chr7	100028615	100028615	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caacacagccatcaactgcaGggatgaagtggtgtctcccc	10	13	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:100028615G>A	uc003uuw.2	+	1	1087	c.974G>A	c.(973-975)AGG>AAG	p.R325K	ZCWPW1_uc003uut.2_5'Flank|ZCWPW1_uc011kjr.1_5'Flank|ZCWPW1_uc003uuu.1_5'Flank|ZCWPW1_uc011kjt.1_5'Flank|ZCWPW1_uc011kju.1_5'Flank|MEPCE_uc003uuv.2_5'UTR	NM_019606	NP_062552	Q7L2J0	MEPCE_HUMAN	bin3, bicoid-interacting 3	325							methyltransferase activity			upper_aerodigestive_tract(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATCAACTGCAGGGATGAAGTG	0.627													0	0	0	0.01441	0	78	110										A	100028615	G	A	100028615	3	1	61	1	0	0	0	0	1	0	0	0	9477	1000	35	2	976	2	MEPCE	7	100028615	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2206596	100028615	59110048	155	17657										
ZAN	7455	broad.mit.edu	37	chr7	100334701	100334701	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagggttcaccctgcccaccCgggtaaggccggggacaaat	13	14	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:100334701C>T	uc003uwj.2	+	5	688	c.523C>T	c.(523-525)CGG>TGG	p.R175W	ZAN_uc003uwk.2_Missense_Mutation_p.R175W|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	175	MAM 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCTGCCCACCCGGGTAAGGCC	0.657													0	0	0	0.013537	0	9	0										T	100334701	C	T	100334701	3	4	61	1	0	0	0	0	1	0	0	0	17510	643	23	2	537	2	ZAN	7	100334701	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	306086	100334701	58803962	156	17658										
ZAN	7455	broad.mit.edu	37	chr7	100382358	100382358	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aagtcccctctgcctgcgctGagggctgcatttgtcagccc	11	15	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:100382358G>A	uc003uwj.2	+	37	6901	c.6736G>A	c.(6736-6738)GAG>AAG	p.E2246K	ZAN_uc003uwk.2_Missense_Mutation_p.E2246K|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.E296K	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2246	Extracellular (Potential).|TIL 4.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCCTGCGCTGAGGGCTGCAT	0.612													0	0	0	0.003954	0	23	36										A	100382358	G	A	100382358	3	1	61	1	0	0	0	0	1	0	0	0	17510	1291	45	1	6873	1	ZAN	7	100382358	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	47657	100382358	58756305	157	17659										
MOGAT3	346606	broad.mit.edu	37	chr7	100843571	100843571	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcccggttccttatccactCcgaacgccttccacctgcgg	8	18	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:100843571C>T	uc003uyc.2	-	3	399	c.232G>A	c.(232-234)GAG>AAG	p.E78K	MOGAT3_uc010lhr.2_Missense_Mutation_p.E78K	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	78					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					CTTATCCACTCCGAACGCCTT	0.562													0	0	0	0.01441	0	81	128										T	100843571	C	T	100843571	3	4	61	1	0	0	0	0	1	0	0	0	9696	864	30	1	813	1	MOGAT3	7	100843571	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	461213	100843571	58295092	158	17660										
ZC3HC1	51530	broad.mit.edu	37	chr7	129680905	129680905	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atattttgcacagacgagtgGagacagctcaaagggcttac	11	8	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:129680905G>C	uc003vpi.2	-	3	322	c.295C>G	c.(295-297)CCA>GCA	p.P99A	ZC3HC1_uc003vph.2_5'UTR|ZC3HC1_uc010lma.2_5'UTR	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	99					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					CAGACGAGTGGAGACAGCTCA	0.368													0	0	0	0.01441	0	110	191										C	129680905	G	C	129680905	3	2	61	1	0	0	0	0	1	0	0	0	17574	1174	41	1	1245	1	ZC3HC1	7	129680905	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	28837334	129680905	29457758	159	17661										
TMEM139	135932	broad.mit.edu	37	chr7	142983919	142983919	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaggacaactgggcacccccTtaaatgactctcccaagatt	8	13	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:142983919T>C	uc010lov.2	+	4	787	c.648T>C	c.(646-648)CCT>CCC	p.P216P	CASP2_uc003wco.2_5'Flank|CASP2_uc003wcp.2_5'Flank|CASP2_uc011kta.1_5'Flank|CASP2_uc003wcq.2_5'Flank|TMEM139_uc003wck.3_Silent_p.P216P|TMEM139_uc003wcl.2_Silent_p.P216P|TMEM139_uc003wcm.2_Silent_p.P216P|TMEM139_uc003wcn.2_RNA	NM_153345	NP_699176	Q8IV31	TM139_HUMAN	transmembrane protein 139 precursor	216	Cytoplasmic (Potential).					integral to membrane					0	Melanoma(164;0.059)					GGGCACCCCCTTAAATGACTC	0.378													0	0	0	0.004672	0	3	164										C	142983919	T	C	142983919	2	2	61	1	0	0	0	0	0	0	0	1	16051	1596	56	5		5	TMEM139	7	142983919	Silent	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	13303014	142983919	16154744	160	17662										
ARHGEF35	445328	broad.mit.edu	37	chr7	143885433	143885433	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgctgaattcctctatggcaGagatgggaggagaggctcca	14	8	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:143885433G>A	uc003wdz.1	-	2	162	c.44C>T	c.(43-45)TCT>TTT	p.S15F		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	15											0						CTCTATGGCAGAGATGGGAGG	0.512													0	0	0	0.00632	0	24	62										A	143885433	G	A	143885433	3	1	61	1	0	0	0	0	1	0	0	0	905	942	33	1	1414	1	ARHGEF35	7	143885433	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	901514	143885433	15253230	161	17663										
NOS3	4846	broad.mit.edu	37	chr7	150693932	150693932	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcacctaccagcttagggaGagcgagctggtgttcggggc	17	10	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:150693932G>C	uc003wif.2	+	5	797	c.501G>C	c.(499-501)GAG>GAC	p.E167D	NOS3_uc011kuy.1_Intron|NOS3_uc011kuz.1_Missense_Mutation_p.E167D|NOS3_uc011kva.1_Missense_Mutation_p.E167D|NOS3_uc011kvb.1_Missense_Mutation_p.E167D	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	167	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	AGCTTAGGGAGAGCGAGCTGG	0.692													0	0	0	0.006214	0	7	11										C	150693932	G	C	150693932	3	2	61	1	0	0	0	0	1	0	0	0	10544	933	33	1	515	1	NOS3	7	150693932	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6808499	150693932	8444731	162	17664										
MLL3	58508	broad.mit.edu	37	chr7	151880184	151880184	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttgctgccttttcatggaatCatttgacatctgtactttat	6	8	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:151880184C>G	uc003wla.2	-	35	5359	c.5140G>C	c.(5140-5142)GAT>CAT	p.D1714H	MLL3_uc003wkz.2_Missense_Mutation_p.D775H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1714					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTCATGGAATCATTTGACATC	0.353			N		medulloblastoma								0	0	0	0.01441	0	162	215										G	151880184	C	G	151880184	3	3	61	1	0	0	0	0	1	0	0	0	9622	826	29	1	9695	1	MLL3	7	151880184	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1186252	151880184	7258479	163	17665										
MLL3	58508	broad.mit.edu	37	chr7	151891214	151891214	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aacatcttttccgccaagctCtaggagataaaacaataata	5	9	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr7:151891214C>G	uc003wla.2	-	31	4760	c.4541_splice	c.e31-1	p.E1514_splice	MLL3_uc003wkz.2_Splice_Site_p.E575_splice	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCGCCAAGCTCTAGGAGATAA	0.418			N		medulloblastoma								0	0	0	0.012213	0	30	32										G	151891214	C	G	151891214	5	3	61	1	0	0	0	0	0	0	1	0	9622	927	32	1	10311	1	MLL3	7	151891214	Splice_Site	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	11030	151891214	7247449	164	17666										
DLGAP2	9228	broad.mit.edu	37	chr8	1645432	1645432	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgcagcggctgcggctcaaCgactggaagatgatggagtc	15	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:1645432C>T	uc003wpl.2	+	11	2773	c.2676C>T	c.(2674-2676)AAC>AAT	p.N892N	DLGAP2_uc003wpm.2_Silent_p.N878N	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	971					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGCGGCTCAACGACTGGAAGA	0.612													0	0	0	0.013537	0	9	114										T	1645432	C	T	1645432	2	4	61	1	0	0	0	0	0	0	0	1	4560	535	19	2		2	DLGAP2	8	1645432	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		1645432	144718590	165	17667										
MFHAS1	9258	broad.mit.edu	37	chr8	8749555	8749555	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tccaggccggtcagctccacGatggagtccggcaggtagcg	15	13	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:8749555G>A	uc003wsj.1	-	1	1577	c.1014C>T	c.(1012-1014)ATC>ATT	p.I338I		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	338	LRR 12.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TCAGCTCCACGATGGAGTCCG	0.637													0	0	0	0.01441	0	63	79										A	8749555	G	A	8749555	2	1	61	1	0	0	0	0	0	0	0	1	9521	1048	37	1		1	MFHAS1	8	8749555	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7104123	8749555	137614467	166	17668										
ENTPD4	9583	broad.mit.edu	37	chr8	23290508	23290508	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agggcggcggccgagctgctCcggggagtgcgcctgtggat	20	11	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:23290508C>T	uc003xdl.2	-	13	1946	c.1782G>A	c.(1780-1782)CGG>CGA	p.R594R	ENTPD4_uc011kzu.1_Intron|ENTPD4_uc003xdm.2_Silent_p.R586R	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	594	Cytoplasmic (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		CCGAGCTGCTCCGGGGAGTGC	0.647													0	0	0	0.00333	0	22	27										T	23290508	C	T	23290508	2	4	61	1	0	0	0	0	0	0	0	1	5141	842	30	1		1	ENTPD4	8	23290508	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	14540953	23290508	123073514	167	17669										
YTHDF3	253943	broad.mit.edu	37	chr8	64099964	64099964	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcccactctatttactcttCagtgtgaatggcagtggaca	10	10	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:64099964C>T	uc003xuy.2	+	5	1711	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	YTHDF3_uc010lys.2_Silent_p.F409F|YTHDF3_uc003xuz.2_Silent_p.F409F|YTHDF3_uc003xva.2_Silent_p.F409F|YTHDF3_uc011len.1_Silent_p.F409F	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	465	YTH.										0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			ATTTACTCTTCAGTGTGAATG	0.448													0	0	0	0.004656	0	22	27										T	64099964	C	T	64099964	2	4	61	1	0	0	0	0	0	0	0	1	17497	838	29	1		1	YTHDF3	8	64099964	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	40809456	64099964	82264058	168	17670										
YTHDF3	253943	broad.mit.edu	37	chr8	64100049	64100049	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgtatgctggtgtctggtctCaggataagtggaagggcaaa	15	6	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:64100049C>G	uc003xuy.2	+	5	1796	c.1480C>G	c.(1480-1482)CAG>GAG	p.Q494E	YTHDF3_uc010lys.2_Missense_Mutation_p.Q438E|YTHDF3_uc003xuz.2_Missense_Mutation_p.Q438E|YTHDF3_uc003xva.2_Missense_Mutation_p.Q438E|YTHDF3_uc011len.1_Missense_Mutation_p.Q438E	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	494	YTH.										0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			TGTCTGGTCTCAGGATAAGTG	0.388													0	0	0	0.006999	0	31	27										G	64100049	C	G	64100049	3	3	61	1	0	0	0	0	1	0	0	0	17497	813	29	1	1493	1	YTHDF3	8	64100049	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	85	64100049	82263973	169	17671										
NCOA2	10499	broad.mit.edu	37	chr8	71068649	71068649	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	taagggcgagggctccatctGatcagatttggtggtcagca	14	8	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:71068649G>A	uc003xyn.1	-	11	2113	c.1951C>T	c.(1951-1953)CAG>TAG	p.Q651*		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	651					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			GGCTCCATCTGATCAGATTTG	0.567			T	RUNXBP2	AML								0	0	0	0.01441	0	48	85										A	71068649	G	A	71068649	4	1	61	1	0	0	0	0	0	1	0	0	10229	1299	45	1	2495	1	NCOA2	8	71068649	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6968600	71068649	75295373	170	17672										
GDAP1	54332	broad.mit.edu	37	chr8	75272520	75272520	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	actgtggactccatgatcccGgcttatgcaactacaaggat	9	11	0	1	rs149804782	byFrequency	TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:75272520G>T	uc003yah.2	+	3	538	c.459G>T	c.(457-459)CCG>CCT	p.P153P	GDAP1_uc011lfj.1_Silent_p.P38P|GDAP1_uc003yai.2_Silent_p.P85P	NM_018972	NP_061845	Q8TB36	GDAP1_HUMAN	ganglioside-induced differentiation-associated	153	GST C-terminal.					cytoplasm					0	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			CCATGATCCCGGCTTATGCAA	0.418													1	0	3.50607e-19	0.01441	3.74944e-19	42	61										T	75272520	G	T	75272520	2	4	61	1	0	0	0	0	0	0	0	1	6307	1103	39	4		4	GDAP1	8	75272520	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4203871	75272520	71091502	171	17673										
ZFHX4	79776	broad.mit.edu	37	chr8	77618708	77618708	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaaaagcacatgcataatatGatgcttttgcagcagaacat	8	7	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:77618708G>A	uc003yav.2	+	2	2772	c.2385G>A	c.(2383-2385)ATG>ATA	p.M795I	ZFHX4_uc003yat.1_Missense_Mutation_p.M795I|ZFHX4_uc003yau.1_Missense_Mutation_p.M795I|ZFHX4_uc003yaw.1_Missense_Mutation_p.M795I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	795						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCATAATATGATGCTTTTGC	0.483										HNSCC(33;0.089)			0	0	0	0.001984	0	6	13										A	77618708	G	A	77618708	3	1	61	1	0	0	0	0	1	0	0	0	17632	1290	45	1	2387	1	ZFHX4	8	77618708	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2346188	77618708	68745314	172	17674										
ZFHX4	79776	broad.mit.edu	37	chr8	77763619	77763619	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atggcctagagcaggaaatgGagagagagtatgaggtggac	17	4	0	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:77763619G>C	uc003yav.2	+	10	4714	c.4327G>C	c.(4327-4329)GAG>CAG	p.E1443Q	ZFHX4_uc003yau.1_Missense_Mutation_p.E1488Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.E1443Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1443						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAGGAAATGGAGAGAGAGTA	0.502										HNSCC(33;0.089)			0	0	0	0.004656	0	21	30										C	77763619	G	C	77763619	3	2	61	1	0	0	0	0	1	0	0	0	17632	1175	41	1	4496	1	ZFHX4	8	77763619	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	144911	77763619	68600403	173	17675										
UBR5	51366	broad.mit.edu	37	chr8	103301750	103301750	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgaacgggctgtgactggctGatgcgcctctgctgtggatt	15	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:103301750G>T	uc003ykr.1	-	35	4677	c.4644C>A	c.(4642-4644)ATC>ATA	p.I1548I	UBR5_uc003yks.1_Silent_p.I1548I	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1548					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GTGACTGGCTGATGCGCCTCT	0.473													1	0	9.7654e-05	0.007413	0.00010009	14	157										T	103301750	G	T	103301750	2	4	61	1	0	0	0	0	0	0	0	1	16902	1280	45	3		3	UBR5	8	103301750	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	25538131	103301750	43062272	174	17676										
TRPS1	7227	broad.mit.edu	37	chr8	116616766	116616766	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	actctggattaaggccgcctGactgcactgctccgtgctgc	11	14	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:116616766G>A	uc003ynz.2	-	3	1850	c.1391C>T	c.(1390-1392)TCA>TTA	p.S464L	TRPS1_uc011lhy.1_Missense_Mutation_p.S468L|TRPS1_uc003yny.2_Missense_Mutation_p.S477L|TRPS1_uc010mcy.2_Missense_Mutation_p.S464L	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	464					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AAGGCCGCCTGACTGCACTGC	0.433									Langer-Giedion_syndrome				0	0	0	0.014323	0	20	34										A	116616766	G	A	116616766	3	1	61	1	0	0	0	0	1	0	0	0	16590	1294	45	1	2470	1	TRPS1	8	116616766	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	13315016	116616766	29747256	175	17677										
ASAP1	50807	broad.mit.edu	37	chr8	131138243	131138243	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttgtctagttccaaagactGaatgcgagaaatatgaaccc	8	8	1	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:131138243G>A	uc003yta.1	-	16	1502	c.1474C>T	c.(1474-1476)CAG>TAG	p.Q492*	ASAP1_uc003ysz.1_Nonsense_Mutation_p.Q303*|ASAP1_uc011liw.1_Nonsense_Mutation_p.Q485*	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	492	Arf-GAP.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TCCAAAGACTGAATGCGAGAA	0.383													0	0	0	0.004878	0	33	48										A	131138243	G	A	131138243	4	1	61	1	0	0	0	0	0	1	0	0	1010	1299	45	1	1971	1	ASAP1	8	131138243	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14521477	131138243	15225779	176	17678										
TOP1MT	116447	broad.mit.edu	37	chr8	144411592	144411592	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcatgatctaacatcctcccAtaaaaagtggcgacctcctc	5	14	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr8:144411592A>G	uc003yxz.2	-	3	307	c.288T>C	c.(286-288)TAT>TAC	p.Y96Y	TOP1MT_uc011lkd.1_5'UTR|TOP1MT_uc011lke.1_5'UTR|TOP1MT_uc010mfb.2_5'UTR|TOP1MT_uc010mfd.1_5'UTR	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	96					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	ACATCCTCCCATAAAAAGTGG	0.552													0	0	0	0.004289	0	30	105										G	144411592	A	G	144411592	2	3	61	1	0	0	0	0	0	0	0	1	16361	224	8	5		5	TOP1MT	8	144411592	Silent	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	13273349	144411592	1952430	177	17679										
PSIP1	11168	broad.mit.edu	37	chr9	15472667	15472667	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcctcttgcttgcgttttcGatctgctgcttctttctcat	6	12	4	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:15472667G>A	uc003zlv.3	-	10	1270	c.940C>T	c.(940-942)CGA>TGA	p.R314*	PSIP1_uc003zlw.3_Nonsense_Mutation_p.R314*|PSIP1_uc003zlz.3_Nonsense_Mutation_p.R314*|PSIP1_uc003zma.3_Nonsense_Mutation_p.R305*|PSIP1_uc003zly.2_Nonsense_Mutation_p.R314*	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	314	Potential.				initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TTGCGTTTTCGATCTGCTGCT	0.363													0	0	0	0.004878	0	32	5										A	15472667	G	A	15472667	4	1	61	1	0	0	0	0	0	1	0	0	12663	1066	37	1	709	1	PSIP1	9	15472667	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		15472667	125740764	178	17680										
C9orf82	79886	broad.mit.edu	37	chr9	26884835	26884835	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctaaatcagatcccatcttaGaaccatcatctgcttcctct	3	14	5	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:26884835G>A	uc003zqc.2	-	4	650	c.638C>T	c.(637-639)TCT>TTT	p.S213F	C9orf82_uc003zqb.2_Missense_Mutation_p.S68F	NM_024828	NP_079104	Q9H8G2	CI082_HUMAN	hypothetical protein LOC79886	213											0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(42;1.39e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TCCCATCTTAGAACCATCATC	0.294													0	0	0	0.01441	0	74	11										A	26884835	G	A	26884835	3	1	61	1	0	0	0	0	1	0	0	0	2499	942	33	1	459	1	C9orf82	9	26884835	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	11412168	26884835	114328596	179	17681										
NPR2	4882	broad.mit.edu	37	chr9	35805555	35805555	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atttcatcgcatgggagtctCaagtcctccaactgtgtggt	10	10	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:35805555C>G	uc003zyd.2	+	13	1935	c.1935C>G	c.(1933-1935)CTC>CTG	p.L645L	NPR2_uc010mlb.2_Silent_p.L621L	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	645	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ATGGGAGTCTCAAGTCCTCCA	0.488													0	0	0	0.01441	0	77	9										G	35805555	C	G	35805555	2	3	61	1	0	0	0	0	0	0	0	1	10595	813	29	1		1	NPR2	9	35805555	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8920720	35805555	105407876	180	17682										
SMC5	23137	broad.mit.edu	37	chr9	72879297	72879297	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caatggaacagggaagtcgaGcattgtgtgtgccatttgcc	13	8	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:72879297G>C	uc004ahr.2	+	2	380	c.263G>C	c.(262-264)AGC>ACC	p.S88T		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	88					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						GGGAAGTCGAGCATTGTGTGT	0.373													0	0	0	0.008871	0	14	34										C	72879297	G	C	72879297	3	2	61	1	0	0	0	0	1	0	0	0	14786	971	34	4	269	4	SMC5	9	72879297	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	37073742	72879297	68334134	181	17683										
NFIL3	4783	broad.mit.edu	37	chr9	94172288	94172288	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttccccatatagttttgataGatggacgctgtgtaagagcc	10	8	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:94172288G>A	uc004arh.2	-	2	1124	c.729C>T	c.(727-729)ATC>ATT	p.I243I		NM_005384	NP_005375	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	243					circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						AGTTTTGATAGATGGACGCTG	0.488													0	0	0	0.01441	0	46	8										A	94172288	G	A	94172288	2	1	61	1	0	0	0	0	0	0	0	1	10373	932	33	1		1	NFIL3	9	94172288	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	21292991	94172288	47041143	182	17684										
ECM2	1842	broad.mit.edu	37	chr9	95277062	95277062	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagcaggaagcggggatcgaGagggcattcggaacatatct	16	7	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:95277062G>C	uc004ash.2	-	4	970	c.905C>G	c.(904-906)TCT>TGT	p.S302C	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.S280C|ECM2_uc011lty.1_Missense_Mutation_p.S302C|ECM2_uc004asg.2_Missense_Mutation_p.S280C	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	302					cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						CGGGGATCGAGAGGGCATTCG	0.403													0	0	0	0.003271	0	31	6										C	95277062	G	C	95277062	3	2	61	1	0	0	0	0	1	0	0	0	4898	942	33	1	1222	1	ECM2	9	95277062	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1104774	95277062	45936369	183	17685										
NANS	54187	broad.mit.edu	37	chr9	100845193	100845193	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attctaacaatggacatgctCaccgtgaaggtgggtgagcc	12	9	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:100845193C>T	uc004ayb.2	+	7	1578	c.936C>T	c.(934-936)CTC>CTT	p.L312L	NANS_uc004ayc.2_Silent_p.L312L|TRIM14_uc004ayd.2_Intron|TRIM14_uc004ayf.1_Intron	NM_018946	NP_061819	Q9NR45	SIAS_HUMAN	N-acetylneuraminic acid phosphate synthase	312	AFP-like.				lipopolysaccharide biosynthetic process	cytoplasm	N-acetylneuraminate synthase activity|N-acylneuraminate cytidylyltransferase activity|N-acylneuraminate-9-phosphate synthase activity			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				TGGACATGCTCACCGTGAAGG	0.493													0	0	0	0.004289	0	32	5										T	100845193	C	T	100845193	2	4	61	1	0	0	0	0	0	0	0	1	10155	813	29	1		1	NANS	9	100845193	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5568131	100845193	40368238	184	17686										
SPTAN1	6709	broad.mit.edu	37	chr9	131342008	131342008	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cactatgcctcagatgaagtGagggagaaggtaagagaaga	14	5	1	6			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:131342008G>A	uc004bvl.3	+	10	1427	c.1314G>A	c.(1312-1314)GTG>GTA	p.V438V	SPTAN1_uc011mbg.1_Silent_p.V438V|SPTAN1_uc011mbh.1_Silent_p.V450V|SPTAN1_uc004bvm.3_Silent_p.V438V|SPTAN1_uc004bvn.3_Silent_p.V438V	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	438	Spectrin 5.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CAGATGAAGTGAGGGAGAAGG	0.428													0	0	0	0.00499	0	15	1										A	131342008	G	A	131342008	2	1	61	1	0	0	0	0	0	0	0	1	15116	1277	45	1		1	SPTAN1	9	131342008	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	30496815	131342008	9871423	185	17687										
OBP2B	29989	broad.mit.edu	37	chr9	136081794	136081794	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gggcctcccggttggtatcaGaattcctacctgcaggtgag	13	11	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr9:136081794G>A	uc004ccz.2	-	5	440	c.398C>T	c.(397-399)TCT>TTT	p.S133F	OBP2B_uc010nad.2_RNA|OBP2B_uc011mcy.1_Missense_Mutation_p.S65F	NM_014581	NP_055396	Q9NPH6	OBP2B_HUMAN	odorant binding protein 2B precursor	133					chemosensory behavior|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.41e-06)|Epithelial(140;1.88e-05)		GTTGGTATCAGAATTCCTACC	0.612													0	0	0	0.00333	0	23	5										A	136081794	G	A	136081794	3	1	61	1	0	0	0	0	1	0	0	0	10811	942	33	1	122	1	OBP2B	9	136081794	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4739786	136081794	5131637	186	17688										
IDI2	91734	broad.mit.edu	37	chr10	1070566	1070566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcaattcctcttggtgtcgGcaccaataaccttatcattc	7	12	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:1070566G>A	uc001ifv.1	-	2	163	c.98C>T	c.(97-99)GCC>GTC	p.A33V	C10orf110_uc010qaf.1_Intron|C10orf110_uc001ifx.3_Intron|C10orf110_uc001ifw.3_Intron|C10orf110_uc001ify.3_Intron	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	33					carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		CTTGGTGTCGGCACCAATAAC	0.478													0	0	0	0.004672	0	3	43										A	1070566	G	A	1070566	3	1	61	1	0	0	0	0	1	0	0	0	7500	1203	42	2	601	2	IDI2	10	1070566	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		1070566	134464181	187	17689										
TAF3	83860	broad.mit.edu	37	chr10	8051117	8051128	+	In_Frame_Del	DEL	GCCCCCGCGCCC	GCCCCCGCGCCC	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggccgaagaccccaccgccgGcccccgcgcccgcccccggc							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:8051117_8051128delGCCCCCGCGCCC	uc010qbd.1	+	5	2392_2403	c.2392_2403delGCCCCCGCGCCC	c.(2392-2403)GCCCCCGCGCCCdel	p.APAP798del		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	798_801	Pro-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						cccaccgccggcccccgcgcccgcccccggcc	0.25																		10	41	---	---								-	8051128	GCCCCCGCGCCC	-	8051117	7	5	61	1	0	1	0	1	0	0	0	0	15522	1203	42	0	2410	0	TAF3	10	8051117	In_Frame_Del	DEL	GCCCCCGCGCCC	TCGA-DK-A3IS-01A-21D-A21A-08	6980551	8051117	127483630	188	17690										
C10orf71	118461	broad.mit.edu	37	chr10	50532111	50532111	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcaacctcaaggacgtgcgGaagcgtgttaagagcacata	11	9	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:50532111G>A	uc010qgp.1	+	3	1860	c.1521G>A	c.(1519-1521)CGG>CGA	p.R507R		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	507											0						AGGACGTGCGGAAGCGTGTTA	0.488													0	0	0	0.010729	0	7	17										A	50532111	G	A	50532111	2	1	61	1	0	0	0	0	0	0	0	1	1614	1161	41	1		1	C10orf71	10	50532111	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	42480994	50532111	85002636	189	17691										
TFAM	7019	broad.mit.edu	37	chr10	60148581	60148581	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agctatgacaaaaaaaaaagTgagtatcattgaaatacttt	6	4	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:60148581T>G	uc001jkf.2	+	4	573	c.441_splice	c.e4+2	p.K147_splice	TFAM_uc001jkg.2_Splice_Site|TFAM_uc001jkh.2_Splice_Site_p.K147_splice	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor						DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						AAAAAAAAAGTGAGTATCATT	0.269													0	0	0	0.010729	0	8	19										G	60148581	T	G	60148581	5	3	61	1	0	0	0	0	0	0	1	0	15783	1710	59	5	457	5	TFAM	10	60148581	Splice_Site	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	9616470	60148581	75386166	190	17692										
JMJD1C	221037	broad.mit.edu	37	chr10	64968350	64968350	+	Nonsense_Mutation	SNP	G	G	A													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agcaacatcaatactttcttGaagaattcgacggtgttcct							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:64968350G>A	uc001jmn.2	-	10	3379	c.3079C>T	c.(3079-3081)CAA>TAA	p.Q1027*	JMJD1C_uc001jml.2_Nonsense_Mutation_p.Q808*|JMJD1C_uc001jmm.2_Nonsense_Mutation_p.Q739*|JMJD1C_uc010qiq.1_Nonsense_Mutation_p.Q845*|JMJD1C_uc009xpi.2_Nonsense_Mutation_p.Q845*|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Nonsense_Mutation_p.Q64*	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1027					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					ATACTTTCTTGAAGAATTCGA	0.418													0	0	0	0.009535	0	30	72										A	64968350	G	A	64968350	4	1	61	1	0	0	0	0	0	1	0	0	7950	1299	45	1	4611	1	JMJD1C	10	64968350	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4819769	64968350	70566397	191	17693	85	2								
JMJD1C	221037	broad.mit.edu	37	chr10	64968353	64968353	+	Missense_Mutation	SNP	G	G	A													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aacatcaatactttcttgaaGaattcgacggtgttcctctt							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:64968353G>A	uc001jmn.2	-	10	3376	c.3076C>T	c.(3076-3078)CTT>TTT	p.L1026F	JMJD1C_uc001jml.2_Missense_Mutation_p.L807F|JMJD1C_uc001jmm.2_Missense_Mutation_p.L738F|JMJD1C_uc010qiq.1_Missense_Mutation_p.L844F|JMJD1C_uc009xpi.2_Missense_Mutation_p.L844F|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.L63F	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1026					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CTTTCTTGAAGAATTCGACGG	0.423													0	0	0	0.012213	0	31	69										A	64968353	G	A	64968353	3	1	61	1	0	0	0	0	1	0	0	0	7950	942	33	1	4614	1	JMJD1C	10	64968353	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3	64968353	70566394	192	17694	85	2								
PBLD	64081	broad.mit.edu	37	chr10	70044041	70044041	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcctcctcggtgggaacactGaaaagctaaagaaaacaaac	8	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:70044041G>A	uc001jns.1	-	10	963	c.760C>T	c.(760-762)CAG>TAG	p.Q254*	PBLD_uc001jnr.1_Nonsense_Mutation_p.Q221*|PBLD_uc001jnt.1_Nonsense_Mutation_p.Q254*	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	254					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TGGGAACACTGAAAAGCTAAA	0.423													0	0	0	0.006122	0	18	31										A	70044041	G	A	70044041	4	1	61	1	0	0	0	0	0	1	0	0	11489	1299	45	1	110	1	PBLD	10	70044041	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5075688	70044041	65490706	193	17695										
ZMIZ1	57178	broad.mit.edu	37	chr10	81072474	81072474	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acctgccgagcaatagtaacGatgacctcctgtctctattt	7	12	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:81072474G>A	uc001kaf.2	+	25	3744	c.3172G>A	c.(3172-3174)GAT>AAT	p.D1058N	ZMIZ1_uc001kag.2_Missense_Mutation_p.D934N|ZMIZ1_uc010qlq.1_Missense_Mutation_p.D124N	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	1058					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CAATAGTAACGATGACCTCCT	0.537													0	0	0	0.01441	0	54	104										A	81072474	G	A	81072474	3	1	61	1	0	0	0	0	1	0	0	0	17693	1058	37	1	3254	1	ZMIZ1	10	81072474	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	11028433	81072474	54462273	194	17696										
NOC3L	64318	broad.mit.edu	37	chr10	96116974	96116974	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attataccacttttatctttGataggaagtaaatgaatcag	6	5	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:96116974G>C	uc001kjq.1	-	4	553	c.465C>G	c.(463-465)ATC>ATG	p.I155M	NOC3L_uc009xuk.1_Translation_Start_Site	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	155						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				TTTTATCTTTGATAGGAAGTA	0.368													0	0	0	0.01441	0	41	33										C	96116974	G	C	96116974	3	2	61	1	0	0	0	0	1	0	0	0	10514	1280	45	1	2009	1	NOC3L	10	96116974	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	15044500	96116974	39417773	195	17697										
SLK	9748	broad.mit.edu	37	chr10	105763061	105763061	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccactgaacctcagcctgttCtaatacccagtattaatatc	4	13	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:105763061C>G	uc001kxo.1	+	9	2159	c.2125C>G	c.(2125-2127)CTA>GTA	p.L709V	SLK_uc001kxp.1_Missense_Mutation_p.L709V	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	709					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TCAGCCTGTTCTAATACCCAG	0.353													0	0	0	0.009718	0	30	20										G	105763061	C	G	105763061	3	3	61	1	0	0	0	0	1	0	0	0	14748	912	32	1	2159	1	SLK	10	105763061	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	9646087	105763061	29771686	196	17698										
ZDHHC6	64429	broad.mit.edu	37	chr10	114192016	114192016	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	accttctataaaggaatcatCaagaattttgtctccatata	4	8	4	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:114192016C>G	uc001kzv.2	-	10	1544	c.1120G>C	c.(1120-1122)GAT>CAT	p.D374H	ZDHHC6_uc001kzw.2_Missense_Mutation_p.D370H	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	374						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		AAGGAATCATCAAGAATTTTG	0.274													0	0	0	0.001168	0	5	11										G	114192016	C	G	114192016	3	3	61	1	0	0	0	0	1	0	0	0	17616	826	29	1	129	1	ZDHHC6	10	114192016	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8428955	114192016	21342731	197	17699										
PAOX	196743	broad.mit.edu	37	chr10	135204914	135204914	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agggaggccgaccgcctcctCagtctgtgggccccgcaggt	15	15	2	0	rs140094339		TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr10:135204914C>T	uc001lmv.2	+	7	1571	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L	PAOX_uc001lmw.2_RNA|PAOX_uc001lmx.2_Nonsense_Mutation_p.Q445*|PAOX_uc001lmy.2_3'UTR|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA|MTG1_uc001lnd.2_5'Flank	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	635					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		ACCGCCTCCTCAGTCTGTGGG	0.662													0	0	0	0.003954	0	24	35										T	135204914	C	T	135204914	2	4	61	1	0	0	0	0	0	0	0	1	11423	827	29	1		1	PAOX	10	135204914	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	21012898	135204914	329833	198	17700										
TRPM5	29850	broad.mit.edu	37	chr11	2436597	2436597	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agctcctgcagccgcccataCgtcaggaagtcggccacgtc	11	16	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:2436597C>T	uc001lwm.3	-	9	1242	c.1233G>A	c.(1231-1233)ACG>ACA	p.T411T	TRPM5_uc010qxl.1_Silent_p.T411T|TRPM5_uc009ydn.2_Silent_p.T413T	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	411	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCCGCCCATACGTCAGGAAGT	0.652													0	0	0	0.000602	0	5	9										T	2436597	C	T	2436597	2	4	61	1	0	0	0	0	0	0	0	1	16586	523	19	2		2	TRPM5	11	2436597	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		2436597	132569919	199	17701										
CCKBR	887	broad.mit.edu	37	chr11	6281307	6281307	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cattcgcggagccgggacacGaggtgggtgcctccctcagc	15	14	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:6281307G>A	uc001mcp.2	+	1	342	c.149G>A	c.(148-150)CGA>CAA	p.R50Q	CCKBR_uc001mcq.2_5'UTR|CCKBR_uc001mcr.2_Missense_Mutation_p.R50Q|CCKBR_uc001mcs.2_Missense_Mutation_p.R50Q	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	50	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GCCGGGACACGAGGTGGGTGC	0.647													0	0	0	0.008361	0	21	29										A	6281307	G	A	6281307	3	1	61	1	0	0	0	0	1	0	0	0	2881	1058	37	1	151	1	CCKBR	11	6281307	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3844710	6281307	128725209	200	17702										
KCNC1	3746	broad.mit.edu	37	chr11	17757753	17757753	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcgtcttcgcgcacatcctGaactactaccgcacgggcaa	10	15	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:17757753G>A	uc001mnk.3	+	1	259	c.204G>A	c.(202-204)CTG>CTA	p.L68L	KCNC1_uc009yhc.1_Silent_p.L68L	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	68	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						CGCACATCCTGAACTACTACC	0.672													0	0	0	0.004656	0	24	33										A	17757753	G	A	17757753	2	1	61	1	0	0	0	0	0	0	0	1	8014	1277	45	1		1	KCNC1	11	17757753	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	11476446	17757753	117248763	201	17703										
SLC17A6	57084	broad.mit.edu	37	chr11	22396376	22396376	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggggacaaattgcagattttCtaagaagcaagcagattctt	10	6	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:22396376C>G	uc001mqk.2	+	9	1530	c.1117C>G	c.(1117-1119)CTA>GTA	p.L373V		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	373	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TGCAGATTTTCTAAGAAGCAA	0.388													0	0	0	0.01441	0	84	103										G	22396376	C	G	22396376	3	3	61	1	0	0	0	0	1	0	0	0	14421	912	32	1	1151	1	SLC17A6	11	22396376	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4638623	22396376	112610140	202	17704										
BBOX1	8424	broad.mit.edu	37	chr11	27077157	27077157	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctagtggaagctcttgatgtGaacattggaattaaaggctt	11	5	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:27077157G>A	uc001mre.1	+	3	548	c.180G>A	c.(178-180)GTG>GTA	p.V60V	BBOX1_uc009yih.1_Silent_p.V60V|BBOX1_uc001mrg.1_Silent_p.V60V	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	60					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	CTCTTGATGTGAACATTGGAA	0.408													0	0	0	0.010729	0	9	12										A	27077157	G	A	27077157	2	1	61	1	0	0	0	0	0	0	0	1	1334	1277	45	1		1	BBOX1	11	27077157	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4680781	27077157	107929359	203	17705										
FNBP4	23360	broad.mit.edu	37	chr11	47767859	47767859	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcttcttcttttattccctCaggcaataaaggagcaagca	6	10	4	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:47767859C>G	uc009ylv.2	-	7	1147	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	FNBP4_uc001ngj.2_Missense_Mutation_p.E239Q|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	332										ovary(1)	1						TTTATTCCCTCAGGCAATAAA	0.398													0	0	0	0.001855	0	13	14										G	47767859	C	G	47767859	3	3	61	1	0	0	0	0	1	0	0	0	5967	835	29	1	2103	1	FNBP4	11	47767859	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	20690702	47767859	87238657	204	17706										
OR4C15	81309	broad.mit.edu	37	chr11	55322235	55322235	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atctcttttgaaggctgcatGatgcagctctttgctgaaca	9	9	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:55322235G>A	uc010rig.1	+	1	453	c.453G>A	c.(451-453)ATG>ATA	p.M151I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAGGCTGCATGATGCAGCTCT	0.483										HNSCC(20;0.049)			0	0	0	0.009718	0	42	66										A	55322235	G	A	55322235	3	1	61	1	0	0	0	0	1	0	0	0	11048	1290	45	1	455	1	OR4C15	11	55322235	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7554376	55322235	79684281	205	17707										
OR5L2	26338	broad.mit.edu	37	chr11	55594854	55594854	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cactgattcaggtcagctctCggctccacacccccgtgtac	8	17	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:55594854C>T	uc001nhy.1	+	1	160	c.160C>T	c.(160-162)CGG>TGG	p.R54W		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				GGTCAGCTCTCGGCTCCACAC	0.473										HNSCC(27;0.073)			0	0	0	0.01441	0	144	59										T	55594854	C	T	55594854	3	4	61	1	0	0	0	0	1	0	0	0	11171	875	31	1	162	1	OR5L2	11	55594854	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	272619	55594854	79411662	206	17708										
SLC15A3	51296	broad.mit.edu	37	chr11	60718900	60718900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcggcgcgctccagcatctCcaccagcagcacggccgcgc	13	19	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:60718900C>T	uc001nqn.2	-	1	358	c.124G>A	c.(124-126)GAG>AAG	p.E42K	SLC15A3_uc001nqo.2_Missense_Mutation_p.E42K	NM_016582	NP_057666	Q8IY34	S15A3_HUMAN	solute carrier family 15, member 3	42	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0						TCCAGCATCTCCACCAGCAGC	0.368													0	0	0	0.009096	0	3	7										T	60718900	C	T	60718900	3	4	61	1	0	0	0	0	1	0	0	0	14400	864	30	1	1653	1	SLC15A3	11	60718900	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5124046	60718900	74287616	207	17709										
C11orf83	790955	broad.mit.edu	37	chr11	62439585	62439585	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgccggcgggaggtcaccgtGagaccggacttgcctccgtg	16	14	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:62439585G>A	uc001nui.3	+	2	373	c.281G>A	c.(280-282)TGA>TAA	p.*94*	C11orf48_uc001nue.2_5'Flank|C11orf48_uc001nuf.2_5'Flank|C11orf48_uc010rmd.1_5'Flank	NM_001085372	NP_001078841	Q6UW78	CK083_HUMAN	hypothetical protein LOC790955 precursor	94						extracellular region					0						AGGTCACCGTGAGACCGGACT	0.687													0	0	0	0.004672	0	2	1										A	62439585	G	A	62439585	2	1	61	1	0	0	0	0	0	0	0	1	1666	1285	45	1		1	C11orf83	11	62439585	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1720685	62439585	72566931	208	17710										
BBS1	582	broad.mit.edu	37	chr11	66299177	66299177	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cccctggagacctttgtggaGagtctcagtaacaagggcat	12	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:66299177G>C	uc001oij.1	+	16	1671	c.1659G>C	c.(1657-1659)GAG>GAC	p.E553D	BBS1_uc001oii.1_Missense_Mutation_p.E590D|BBS1_uc010rpg.1_Missense_Mutation_p.E456D|BBS1_uc001oik.1_Missense_Mutation_p.E477D|BBS1_uc001oil.1_Missense_Mutation_p.E424D|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Missense_Mutation_p.E221D	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	553					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						CCTTTGTGGAGAGTCTCAGTA	0.552									Bardet-Biedl_syndrome				0	0	0	0.01441	0	61	99										C	66299177	G	C	66299177	3	2	61	1	0	0	0	0	1	0	0	0	1335	933	33	1	1721	1	BBS1	11	66299177	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3859592	66299177	68707339	209	17711										
PRKRIR	5612	broad.mit.edu	37	chr11	76062117	76062117	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attttcataccgctcattctCaaccttcatcacaggaagaa	4	12	5	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:76062117C>G	uc001oxh.1	-	5	2077	c.2077G>C	c.(2077-2079)GAG>CAG	p.E693Q	PRKRIR_uc010rrz.1_Missense_Mutation_p.E518Q	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	693					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CGCTCATTCTCAACCTTCATC	0.418													0	0	0	0.00874	0	34	20										G	76062117	C	G	76062117	3	3	61	1	0	0	0	0	1	0	0	0	12526	835	29	1	212	1	PRKRIR	11	76062117	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	9762940	76062117	58944399	210	17712										
PRKRIR	5612	broad.mit.edu	37	chr11	76062585	76062585	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgccaaatttgtggcttcctCaaaccaaaattcatgataaa	5	9	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:76062585C>G	uc001oxh.1	-	5	1609	c.1609G>C	c.(1609-1611)GAG>CAG	p.E537Q	PRKRIR_uc010rrz.1_Missense_Mutation_p.E362Q	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	537					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						GTGGCTTCCTCAAACCAAAAT	0.428													0	0	0	0.006214	0	7	13										G	76062585	C	G	76062585	3	3	61	1	0	0	0	0	1	0	0	0	12526	835	29	1	680	1	PRKRIR	11	76062585	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	468	76062585	58943931	211	17713										
ODZ4	26011	broad.mit.edu	37	chr11	78516497	78516497	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagtggcattcgcctctcacGcagacaccccggcctgaaca	9	17	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:78516497G>A	uc001ozl.3	-	15	2482	c.2019C>T	c.(2017-2019)TGC>TGT	p.C673C		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	673	EGF-like 4.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CGCCTCTCACGCAGACACCCC	0.582													0	0	0	0.001168	0	4	12										A	78516497	G	A	78516497	2	1	61	1	0	0	0	0	0	0	0	1	10837	1079	38	2		2	ODZ4	11	78516497	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2453912	78516497	56490019	212	17714										
GRM5	2915	broad.mit.edu	37	chr11	88780766	88780766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aggagtcccttatctcacagCccagtgtgatgttgggcaag	12	10	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:88780766C>T	uc001pcq.2	-	1	475	c.275G>A	c.(274-276)GGC>GAC	p.G92D	GRM5_uc009yvm.2_Missense_Mutation_p.G92D|GRM5_uc009yvn.1_Missense_Mutation_p.G92D	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	92	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.G92R(1)		central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TATCTCACAGCCCAGTGTGAT	0.522													0	0	0	0.003163	0	10	16										T	88780766	C	T	88780766	3	4	61	1	0	0	0	0	1	0	0	0	6800	739	26	2	3399	2	GRM5	11	88780766	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	10264269	88780766	46225750	213	17715										
AMOTL1	154810	broad.mit.edu	37	chr11	94533413	94533413	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcaagccctaccctgctcctCagcctgtgagaacagatgtg	9	14	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:94533413C>T	uc001pfb.2	+	3	1227	c.1057C>T	c.(1057-1059)CAG>TAG	p.Q353*	AMOTL1_uc001pfc.2_Nonsense_Mutation_p.Q303*	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	353						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCCTGCTCCTCAGCCTGTGAG	0.567													0	0	0	0.01441	0	54	99										T	94533413	C	T	94533413	4	4	61	1	0	0	0	0	0	1	0	0	583	827	29	1	1067	1	AMOTL1	11	94533413	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5752647	94533413	40473103	214	17716										
BIRC3	330	broad.mit.edu	37	chr11	102195686	102195686	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atcaaatcctgtaaactccaGagcaaatcaagatttttctg	5	9	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:102195686G>C	uc001pgx.2	+	3	668	c.446G>C	c.(445-447)AGA>ACA	p.R149T		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	149					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		GTAAACTCCAGAGCAAATCAA	0.393			T	MALT1	MALT								0	0	0	0.01441	0	41	73										C	102195686	G	C	102195686	3	2	61	1	0	0	0	0	1	0	0	0	1436	942	33	1	448	1	BIRC3	11	102195686	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7662273	102195686	32810830	215	17717										
DYNC2H1	79659	broad.mit.edu	37	chr11	102980483	102980483	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagcgatccgacgcaggaatCtccttttccaacacggtacg	9	14	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:102980483C>G	uc001pho.2	+	1	324	c.180C>G	c.(178-180)ATC>ATG	p.I60M	DYNC2H1_uc001phn.1_Missense_Mutation_p.I60M|DYNC2H1_uc009yxe.1_Missense_Mutation_p.I60M	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	60	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ACGCAGGAATCTCCTTTTCCA	0.557													0	0	0	0.012213	0	27	21										G	102980483	C	G	102980483	3	3	61	1	0	0	0	0	1	0	0	0	4846	903	32	1	182	1	DYNC2H1	11	102980483	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	784797	102980483	32026033	216	17718										
EXPH5	23086	broad.mit.edu	37	chr11	108383904	108383904	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtatatacattttggaggtaTctttcctggaaaagactctg	9	6	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:108383904T>A	uc001pkk.2	-	6	2441	c.2330A>T	c.(2329-2331)GAT>GTT	p.D777V	EXPH5_uc010rvy.1_Missense_Mutation_p.D589V|EXPH5_uc010rvz.1_Missense_Mutation_p.D621V|EXPH5_uc010rwa.1_Missense_Mutation_p.D701V	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	777					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTTGGAGGTATCTTTCCTGGA	0.388													0	0	0	0.01441	0	34	52										A	108383904	T	A	108383904	3	1	61	1	0	0	0	0	1	0	0	0	5322	1435	50	5	3643	5	EXPH5	11	108383904	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	5403421	108383904	26622612	217	17719										
C11orf57	55216	broad.mit.edu	37	chr11	111946331	111946331	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccactggggaaggtcctcctGaggaatgtcatccggcacac	12	13	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:111946331G>T	uc001pmr.3	+	2	714	c.33G>T	c.(31-33)CTG>CTT	p.L11L	PIH1D2_uc009yyl.2_5'Flank|PIH1D2_uc001pmq.3_5'Flank|PIH1D2_uc001pmp.3_5'Flank|PIH1D2_uc010rws.1_5'Flank|C11orf57_uc001pmu.2_Silent_p.L11L|C11orf57_uc001pmw.3_Silent_p.L11L|C11orf57_uc001pmt.3_Silent_p.L11L|C11orf57_uc001pmv.3_Silent_p.L11L|C11orf57_uc001pms.3_5'UTR	NM_001082970	NP_001076439	Q6ZUT1	CK057_HUMAN	hypothetical protein LOC55216 isoform b	11										breast(2)|ovary(1)	3		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		AGGTCCTCCTGAGGAATGTCA	0.413													1	0	6.07407e-21	0.007291	6.52401e-21	22	25										T	111946331	G	T	111946331	2	4	61	1	0	0	0	0	0	0	0	1	1650	1277	45	3		3	C11orf57	11	111946331	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3562427	111946331	23060185	218	17720										
IFT46	56912	broad.mit.edu	37	chr11	118416128	118416128	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgatgcttggctcacctgtGagttcttgaattctgagtag	11	8	3	4	rs45508996		TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:118416128G>C	uc001ptp.1	-	11	1193	c.815C>G	c.(814-816)TCA>TGA	p.S272*	TMEM25_uc001ptl.2_Intron|TMEM25_uc001ptm.2_Intron|TMEM25_uc001ptn.2_Intron|IFT46_uc001pto.1_Nonsense_Mutation_p.S323*|IFT46_uc009zaf.1_Intron	NM_020153	NP_064538	Q9NQC8	IFT46_HUMAN	IFT46	272					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding				0						GCTCACCTGTGAGTTCTTGAA	0.458													0	0	0	0.01441	0	56	47										C	118416128	G	C	118416128	4	2	61	1	0	0	0	0	0	1	0	0	7560	1294	45	1	107	1	IFT46	11	118416128	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6469797	118416128	16590388	219	17721										
HINFP	25988	broad.mit.edu	37	chr11	119003647	119003647	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagcctacaggtgtgattttGagaactgcaccttcagtgcc	10	11	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:119003647G>T	uc001pvp.2	+	9	1138	c.949G>T	c.(949-951)GAG>TAG	p.E317*	HINFP_uc001pvq.2_Nonsense_Mutation_p.E317*|HINFP_uc001pvr.2_Nonsense_Mutation_p.E70*	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	317	C2H2-type 8.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GTGTGATTTTGAGAACTGCAC	0.517													1	0	1.00905e-13	0.008871	1.06751e-13	19	42										T	119003647	G	T	119003647	4	4	61	1	0	0	0	0	0	1	0	0	7110	1291	45	3	975	3	HINFP	11	119003647	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	587519	119003647	16002869	220	17722										
HSPA8	3312	broad.mit.edu	37	chr11	122931883	122931883	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttctttgcggcatcaccgatCaaccgttcagtgtccgtaaa	8	12	4	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:122931883C>T	uc001pyo.2	-	2	228	c.150G>A	c.(148-150)TTG>TTA	p.L50L	HSPA8_uc009zbc.2_5'Flank|HSPA8_uc001pyp.2_Silent_p.L50L|HSPA8_uc010rzu.1_Silent_p.L50L|HSPA8_uc009zbd.1_Silent_p.L50L|HSPA8_uc010rzv.1_Silent_p.L50L	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	50					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CATCACCGATCAACCGTTCAG	0.448													0	0	0	0.008871	0	15	33										T	122931883	C	T	122931883	2	4	61	1	0	0	0	0	0	0	0	1	7416	825	29	1		1	HSPA8	11	122931883	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3928236	122931883	12074633	221	17723										
OR10G8	219869	broad.mit.edu	37	chr11	123900527	123900527	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcctcaccaacctgtcgttCattgacatgtggttctccac	6	14	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:123900527C>T	uc001pzp.1	+	1	198	c.198C>T	c.(196-198)TTC>TTT	p.F66F		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		ACCTGTCGTTCATTGACATGT	0.542													0	0	0	0.01441	0	48	101										T	123900527	C	T	123900527	2	4	61	1	0	0	0	0	0	0	0	1	10903	825	29	1		1	OR10G8	11	123900527	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	968644	123900527	11105989	222	17724										
KIRREL3	84623	broad.mit.edu	37	chr11	126294664	126294664	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aggaaggagctgctgtcgctGagggagcctctctggaactc	15	10	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:126294664G>T	uc001qea.2	-	17	2509	c.2148C>A	c.(2146-2148)CTC>CTA	p.L716L	KIRREL3_uc001qeb.2_Silent_p.L704L|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	716	Cytoplasmic (Potential).|Ser-rich.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TGCTGTCGCTGAGGGAGCCTC	0.632													1	0	2.27111e-07	0.013537	2.35717e-07	11	27										T	126294664	G	T	126294664	2	4	61	1	0	0	0	0	0	0	0	1	8326	1277	45	3		3	KIRREL3	11	126294664	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2394137	126294664	8711852	223	17725										
ST14	6768	broad.mit.edu	37	chr11	130058506	130058506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtggatgcctacgagaactCcaactccactgagtttgtaa	9	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:130058506C>T	uc001qfw.2	+	3	516	c.323C>T	c.(322-324)TCC>TTC	p.S108F	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	108	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	TACGAGAACTCCAACTCCACT	0.562													0	0	0	0.008361	0	23	50										T	130058506	C	T	130058506	3	4	61	1	0	0	0	0	1	0	0	0	15210	855	30	1	333	1	ST14	11	130058506	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3763842	130058506	4948010	224	17726										
ST14	6768	broad.mit.edu	37	chr11	130066275	130066275	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaggtgcgcttcaaattcttCtacctgctggagcccggcgt	11	12	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:130066275C>T	uc001qfw.2	+	10	1348	c.1155C>T	c.(1153-1155)TTC>TTT	p.F385F	ST14_uc010sca.1_Silent_p.F195F	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	385	CUB 2.|Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	TCAAATTCTTCTACCTGCTGG	0.632													0	0	0	0.006214	0	6	7										T	130066275	C	T	130066275	2	4	61	1	0	0	0	0	0	0	0	1	15210	912	32	1		1	ST14	11	130066275	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	7769	130066275	4940241	225	17727										
NTM	50863	broad.mit.edu	37	chr11	132184470	132184470	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attgaaggaaagaaaggggtGaaagtggaaaacagaccttt	13	3	0	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr11:132184470G>A	uc001qgp.2	+	6	1471	c.807G>A	c.(805-807)GTG>GTA	p.V269V	NTM_uc001qgm.2_Silent_p.V269V|NTM_uc010sch.1_Silent_p.V260V|NTM_uc010sci.1_Silent_p.V269V|NTM_uc010scj.1_Silent_p.V228V|NTM_uc001qgo.2_Silent_p.V269V|NTM_uc001qgq.2_Silent_p.V269V|NTM_uc001qgr.2_Silent_p.V51V	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	269	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						AGAAAGGGGTGAAAGTGGAAA	0.433													0	0	0	0.004672	0	3	22										A	132184470	G	A	132184470	2	1	61	1	0	0	0	0	0	0	0	1	10699	1277	45	1		1	NTM	11	132184470	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2118195	132184470	2822046	226	17728										
C1S	716	broad.mit.edu	37	chr12	7177945	7177945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcaggaaaatagcaccccccGtgaggactaatccagataca	9	12	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:7177945G>A	uc001qsj.2	+	15	2776	c.2057G>A	c.(2056-2058)CGT>CAT	p.R686H	C1S_uc001qsk.2_Missense_Mutation_p.R686H|C1S_uc001qsl.2_Missense_Mutation_p.R686H|C1S_uc009zfr.2_Missense_Mutation_p.R519H|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	686					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	AGCACCCCCCGTGAGGACTAA	0.483													0	0	0	0.01441	0	45	71										A	7177945	G	A	7177945	3	1	61	1	0	0	0	0	1	0	0	0	1974	1145	40	2	2099	2	C1S	12	7177945	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		7177945	126673950	227	17729										
C12orf60	144608	broad.mit.edu	37	chr12	14975926	14975926	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attcaagctgccaaaatgttCttctttcatgtacaagatct	5	9	5	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:14975926C>T	uc001rcj.3	+	2	261	c.57C>T	c.(55-57)TTC>TTT	p.F19F		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	19										ovary(1)|central_nervous_system(1)	2						CCAAAATGTTCTTCTTTCATG	0.368													0	0	0	0.00632	0	27	48										T	14975926	C	T	14975926	2	4	61	1	0	0	0	0	0	0	0	1	1703	912	32	1		1	C12orf60	12	14975926	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	7797981	14975926	118875969	228	17730										
PLEKHA5	54477	broad.mit.edu	37	chr12	19427759	19427759	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agttcagagaacaaaatagtCaatgttagcctggcagatct	9	7	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:19427759C>G	uc001reb.2	+	10	1223	c.1137C>G	c.(1135-1137)GTC>GTG	p.V379V	PLEKHA5_uc010sie.1_Silent_p.V385V|PLEKHA5_uc001rea.2_Silent_p.V379V|PLEKHA5_uc009zin.2_Silent_p.V137V|PLEKHA5_uc010sif.1_Silent_p.V271V|PLEKHA5_uc010sig.1_Silent_p.V271V|PLEKHA5_uc010sih.1_Silent_p.V271V|PLEKHA5_uc001rec.1_Silent_p.V67V	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	379							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACAAAATAGTCAATGTTAGCC	0.468													0	0	0	0.009535	0	29	60										G	19427759	C	G	19427759	2	3	61	1	0	0	0	0	0	0	0	1	12059	813	29	1		1	PLEKHA5	12	19427759	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4451833	19427759	114424136	229	17731										
CAPRIN2	65981	broad.mit.edu	37	chr12	30906540	30906540	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gttgcaccattgaaacagatGaggctgaaggaggtggggga	17	5	0	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:30906540G>A	uc001rji.1	-	1	909	c.158C>T	c.(157-159)TCA>TTA	p.S53L	CAPRIN2_uc001rjg.1_5'Flank|CAPRIN2_uc001rjh.1_Missense_Mutation_p.S53L|CAPRIN2_uc001rjj.1_5'UTR|CAPRIN2_uc001rjk.3_Missense_Mutation_p.S53L|CAPRIN2_uc001rjl.3_Missense_Mutation_p.S53L	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	53					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TGAAACAGATGAGGCTGAAGG	0.463											OREG0021723	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	46	50										A	30906540	G	A	30906540	3	1	61	1	0	0	0	0	1	0	0	0	2636	1294	45	1	3297	1	CAPRIN2	12	30906540	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	11478781	30906540	102945355	230	17732										
DENND5B	160518	broad.mit.edu	37	chr12	31540565	31540565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccactcctttgatgagtgatCcttctaggactatggtgaag	10	9	1	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:31540565C>T	uc001rki.1	-	21	3983	c.3797G>A	c.(3796-3798)GGA>GAA	p.G1266E	DENND5B_uc001rkh.1_Missense_Mutation_p.G1301E|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1266	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GATGAGTGATCCTTCTAGGAC	0.498													0	0	0	0.00632	0	20	33										T	31540565	C	T	31540565	3	4	61	1	0	0	0	0	1	0	0	0	4437	855	30	1	31	1	DENND5B	12	31540565	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	634025	31540565	102311330	231	17733			3	75		3	3	73	C		4.701897e-07
DENND5B	160518	broad.mit.edu	37	chr12	31540607	31540607	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctgaatggtctgcagaattCggataagggagttgacagtc	13	7	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:31540607C>T	uc001rki.1	-	21	3941	c.3755G>A	c.(3754-3756)CGA>CAA	p.R1252Q	DENND5B_uc001rkh.1_Missense_Mutation_p.R1287Q|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1252	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						CTGCAGAATTCGGATAAGGGA	0.488													0	0	0	0.006122	0	16	29										T	31540607	C	T	31540607	3	4	61	1	0	0	0	0	1	0	0	0	4437	884	31	1	73	1	DENND5B	12	31540607	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	42	31540607	102311288	232	17734			3	75		3	3	73	C		4.701897e-07
DENND5B	160518	broad.mit.edu	37	chr12	31540637	31540637	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agttgacagtcatgcggtctCgcaggagagcgctctcttca	12	11	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:31540637C>G	uc001rki.1	-	21	3911	c.3725G>C	c.(3724-3726)CGA>CCA	p.R1242P	DENND5B_uc001rkh.1_Missense_Mutation_p.R1277P|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1242	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						CATGCGGTCTCGCAGGAGAGC	0.498													0	0	0	0.00632	0	22	28										G	31540637	C	G	31540637	3	3	61	1	0	0	0	0	1	0	0	0	4437	884	31	1	103	1	DENND5B	12	31540637	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	30	31540637	102311258	233	17735			3	75		3	3	73	C		4.701897e-07
DIP2B	57609	broad.mit.edu	37	chr12	51072628	51072628	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtctgactgcactggacatGacagggaaaccagtttacac	10	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:51072628G>A	uc001rwv.2	+	8	1239	c.1083G>A	c.(1081-1083)ATG>ATA	p.M361I	DIP2B_uc001rwu.2_Missense_Mutation_p.M361I|DIP2B_uc009zls.1_Missense_Mutation_p.M243I	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	361						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CACTGGACATGACAGGGAAAC	0.468													0	0	0	0.005524	0	30	56										A	51072628	G	A	51072628	3	1	61	1	0	0	0	0	1	0	0	0	4528	1290	45	1	1113	1	DIP2B	12	51072628	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	19531991	51072628	82779267	234	17736										
KRT6C	286887	broad.mit.edu	37	chr12	52865237	52865237	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggctctcaggaagttgatctCatctgtgagagtgtctgcct	12	9	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:52865237C>T	uc001sal.3	-	4	928	c.880G>A	c.(880-882)GAG>AAG	p.E294K		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	294	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		AAGTTGATCTCATCTGTGAGA	0.488													0	0	0	0.01441	0	42	74										T	52865237	C	T	52865237	3	4	61	1	0	0	0	0	1	0	0	0	8482	835	29	1	838	1	KRT6C	12	52865237	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1792609	52865237	80986658	235	17737										
KRT79	338785	broad.mit.edu	37	chr12	53227586	53227586	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	accttgtcgatgaaggaggcGaacttgttgttgagggtctt	14	6	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:53227586G>A	uc001sbb.2	-	1	492	c.459C>T	c.(457-459)TTC>TTT	p.F153F		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	153	Rod.|Coil 1A.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						TGAAGGAGGCGAACTTGTTGT	0.607													0	0	0	0.01441	0	81	122										A	53227586	G	A	53227586	2	1	61	1	0	0	0	0	0	0	0	1	8492	1049	37	1		1	KRT79	12	53227586	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	362349	53227586	80624309	236	17738										
KRT79	338785	broad.mit.edu	37	chr12	53227664	53227664	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcggggtcaatctccacatgGaggggggtcagcaggctctg	16	10	4	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:53227664G>C	uc001sbb.2	-	1	414	c.381C>G	c.(379-381)CTC>CTG	p.L127L		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	127	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						TCTCCACATGGAGGGGGGTCA	0.602													0	0	0	0.01441	0	46	70										C	53227664	G	C	53227664	2	2	61	1	0	0	0	0	0	0	0	1	8492	1161	41	1		1	KRT79	12	53227664	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	78	53227664	80624231	237	17739										
GDF11	10220	broad.mit.edu	37	chr12	56137466	56137466	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctacacgacttccagggcgaCgcgctgcagcccgaggactt	12	15	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:56137466C>G	uc001shq.2	+	1	403	c.366C>G	c.(364-366)GAC>GAG	p.D122E	GDF11_uc010spv.1_Missense_Mutation_p.D122E	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	122					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						TCCAGGGCGACGCGCTGCAGC	0.667													0	0	0	0.00632	0	24	19										G	56137466	C	G	56137466	3	3	61	1	0	0	0	0	1	0	0	0	6312	535	19	4	368	4	GDF11	12	56137466	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2909802	56137466	77714429	238	17740										
DGKA	1606	broad.mit.edu	37	chr12	56345848	56345848	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attgctcatcgattccacatCatgcgagagaaatatccgga	8	10	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:56345848C>T	uc001sij.2	+	19	1881	c.1617C>T	c.(1615-1617)ATC>ATT	p.I539I	DGKA_uc001sii.1_Silent_p.I397I|DGKA_uc009zod.1_Silent_p.I458I|DGKA_uc001sik.2_Silent_p.I539I|DGKA_uc001sil.2_Silent_p.I539I|DGKA_uc001sim.2_Silent_p.I539I|DGKA_uc001sin.2_Silent_p.I539I|DGKA_uc009zof.2_Silent_p.I185I|DGKA_uc001sio.2_Silent_p.I281I	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	539					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	GATTCCACATCATGCGAGAGA	0.522													0	0	0	0.01441	0	73	53										T	56345848	C	T	56345848	2	4	61	1	0	0	0	0	0	0	0	1	4465	816	29	1		1	DGKA	12	56345848	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	208382	56345848	77506047	239	17741										
PAN2	9924	broad.mit.edu	37	chr12	56717846	56717846	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttgctaccatcagggtaggaGagtgtgaaaagcagagtgga	15	5	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:56717846G>C	uc001skx.2	-	13	2425	c.2052C>G	c.(2050-2052)CTC>CTG	p.L684L	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Silent_p.L683L|PAN2_uc001sky.2_Silent_p.L684L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	684					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CAGGGTAGGAGAGTGTGAAAA	0.532													0	0	0	0.01441	0	99	80										C	56717846	G	C	56717846	2	2	61	1	0	0	0	0	0	0	0	1	11414	929	33	1		1	PAN2	12	56717846	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	371998	56717846	77134049	240	17742										
TMBIM4	51643	broad.mit.edu	37	chr12	66531814	66531814	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatatccaagtagaggctgaTggcagctaatacgtactctt	10	8	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:66531814T>C	uc001stc.2	-	7	719	c.643A>G	c.(643-645)ATC>GTC	p.I215V	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Missense_Mutation_p.I184V|TMBIM4_uc009zqr.2_Missense_Mutation_p.I262V|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	215	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		TAGAGGCTGATGGCAGCTAAT	0.418													0	0	0	0.01441	0	35	80										C	66531814	T	C	66531814	3	2	61	1	0	0	0	0	1	0	0	0	15979	1464	51	5	77	5	TMBIM4	12	66531814	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	9813968	66531814	67320081	241	17743										
ATP2B1	490	broad.mit.edu	37	chr12	89997570	89997570	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	catcattgtacgtgagatgaGaggcttatttctaccataag	9	7	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:89997570G>C	uc001tbh.2	-	16	2948	c.2767C>G	c.(2767-2769)CTC>GTC	p.L923V	ATP2B1_uc001tbg.2_Missense_Mutation_p.L923V|ATP2B1_uc001tbf.2_Missense_Mutation_p.L593V	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	923	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						CGTGAGATGAGAGGCTTATTT	0.418													0	0	0	0.01441	0	48	67										C	89997570	G	C	89997570	3	2	61	1	0	0	0	0	1	0	0	0	1139	942	33	1	1073	1	ATP2B1	12	89997570	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	23465756	89997570	43854325	242	17744										
GLT8D2	83468	broad.mit.edu	37	chr12	104388223	104388223	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaagagcaggtgctggggctGatgccaaggtccttgatggc	16	8	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:104388223G>A	uc001tkh.1	-	9	1063	c.657C>T	c.(655-657)ATC>ATT	p.I219I	GLT8D2_uc001tki.1_Silent_p.I219I	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	219	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2						TGCTGGGGCTGATGCCAAGGT	0.483													0	0	0	0.013726	0	28	27										A	104388223	G	A	104388223	2	1	61	1	0	0	0	0	0	0	0	1	6470	1280	45	1		1	GLT8D2	12	104388223	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14390653	104388223	29463672	243	17745										
APPL2	55198	broad.mit.edu	37	chr12	105582222	105582222	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	taaacatctgctgcaaaagaGaatctggaagacagcatttt	8	7	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:105582222G>T	uc001tlf.1	-	17	1681	c.1463C>A	c.(1462-1464)TCT>TAT	p.S488Y	APPL2_uc010swt.1_Missense_Mutation_p.S445Y|APPL2_uc001tlg.1_Missense_Mutation_p.S242Y|APPL2_uc010swu.1_Missense_Mutation_p.S494Y|APPL2_uc009zuq.2_Missense_Mutation_p.S445Y	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	488	PID.				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CTGCAAAAGAGAATCTGGAAG	0.418													1	0	2.37509e-13	0.010504	2.50732e-13	17	20										T	105582222	G	T	105582222	3	4	61	1	0	0	0	0	1	0	0	0	818	942	33	3	551	3	APPL2	12	105582222	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1193999	105582222	28269673	244	17746										
MYO1H	283446	broad.mit.edu	37	chr12	109872912	109872912	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctttgaatttagtaaacatCaactaggtatgatttctttt	5	6	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:109872912C>T	uc010sxn.1	+	20	2086	c.2086C>T	c.(2086-2088)CAA>TAA	p.Q696*		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						TAGTAAACATCAACTAGGTAT	0.343													0	0	0	0.013537	0	10	18										T	109872912	C	T	109872912	4	4	61	1	0	0	0	0	0	1	0	0	10075	827	29	1	2164	1	MYO1H	12	109872912	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4290690	109872912	23978983	245	17747										
RBM19	9904	broad.mit.edu	37	chr12	114392942	114392942	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagttagcacatacctctgtGacattgaacggggctccccg	10	13	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:114392942G>A	uc009zwi.2	-	7	1059	c.915C>T	c.(913-915)GTC>GTT	p.V305V	RBM19_uc001tvn.3_Silent_p.V305V|RBM19_uc001tvm.2_Silent_p.V305V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	305	RRM 2.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					ATACCTCTGTGACATTGAACG	0.572													0	0	0	0.001168	0	4	155										A	114392942	G	A	114392942	2	1	61	1	0	0	0	0	0	0	0	1	13121	1277	45	1		1	RBM19	12	114392942	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4520030	114392942	19458953	246	17748										
FBXO21	23014	broad.mit.edu	37	chr12	117595695	117595695	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cacctcttatgcttcataatGagcccgatggagtagcagac	9	11	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:117595695G>A	uc001twk.2	-	10	1560	c.1521C>T	c.(1519-1521)CTC>CTT	p.L507L	FBXO21_uc001twj.2_Silent_p.L500L|FBXO21_uc009zwq.2_Silent_p.L440L|FBXO21_uc001twl.1_Silent_p.L120L	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	507					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GCTTCATAATGAGCCCGATGG	0.562													0	0	0	0.01441	0	51	65										A	117595695	G	A	117595695	2	1	61	1	0	0	0	0	0	0	0	1	5733	1277	45	1		1	FBXO21	12	117595695	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3202753	117595695	16256200	247	17749										
WSB2	55884	broad.mit.edu	37	chr12	118490215	118490215	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaaggcgacgctccaggtttCacagctggacttccaatcaa	10	12	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:118490215C>G	uc001twr.2	-	2	180	c.82G>C	c.(82-84)GAA>CAA	p.E28Q	WSB2_uc010sza.1_5'UTR|WSB2_uc010szb.1_5'UTR|WSB2_uc009zws.1_Missense_Mutation_p.E28Q	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	28					intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCCAGGTTTCACAGCTGGAC	0.587													0	0	0	0.01441	0	78	106										G	118490215	C	G	118490215	3	3	61	1	0	0	0	0	1	0	0	0	17402	835	29	1	1164	1	WSB2	12	118490215	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	894520	118490215	15361680	248	17750										
GPR81	27198	broad.mit.edu	37	chr12	123214482	123214482	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agggcccacagggtgcagacGatgccagccgccacccgggt	15	15	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:123214482G>A	uc001ucz.2	-	1	648	c.405C>T	c.(403-405)ATC>ATT	p.I135I	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	135	Helical; Name=4; (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGGTGCAGACGATGCCAGCCG	0.592													0	0	0	0.01441	0	63	60										A	123214482	G	A	123214482	2	1	61	1	0	0	0	0	0	0	0	1	6711	1048	37	1		1	GPR81	12	123214482	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4724267	123214482	10637413	249	17751										
DNAH10	196385	broad.mit.edu	37	chr12	124415937	124415937	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acgccagaagtgtttggtctCcaccccaacgctgagattgg	11	12	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:124415937C>G	uc001uft.3	+	73	12505	c.12480C>G	c.(12478-12480)CTC>CTG	p.L4160L	DNAH10_uc001ufu.3_Silent_p.L73L	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4160					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGTTTGGTCTCCACCCCAACG	0.577													0	0	0	0.004878	0	29	49										G	124415937	C	G	124415937	2	3	61	1	0	0	0	0	0	0	0	1	4598	842	30	1		1	DNAH10	12	124415937	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1201455	124415937	9435958	250	17752										
DHX37	57647	broad.mit.edu	37	chr12	125451375	125451375	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttggccctggcccttgacttCttaaacttccgcatttcctc	6	15	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr12:125451375C>T	uc001ugy.2	-	12	1653	c.1554G>A	c.(1552-1554)AAG>AAA	p.K518K		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	518	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCCTTGACTTCTTAAACTTCC	0.537													0	0	0	0.013114	0	34	58										T	125451375	C	T	125451375	2	4	61	1	0	0	0	0	0	0	0	1	4510	912	32	1		1	DHX37	12	125451375	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1035438	125451375	8400520	251	17753										
ZMYM2	7750	broad.mit.edu	37	chr13	20608481	20608481	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	catattgcgaatactgtcaaGaggagaagactcttcatgaa	9	7	3	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:20608481G>A	uc001umr.2	+	12	2354	c.2056G>A	c.(2056-2058)GAG>AAG	p.E686K	ZMYM2_uc001ums.2_Missense_Mutation_p.E686K|ZMYM2_uc001umt.2_Missense_Mutation_p.E686K|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_Missense_Mutation_p.E66K|ZMYM2_uc001umw.2_Missense_Mutation_p.E139K	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	686	MYM-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		ATACTGTCAAGAGGAGAAGAC	0.358													0	0	0	0.013726	0	30	53										A	20608481	G	A	20608481	3	1	61	1	0	0	0	0	1	0	0	0	17697	943	33	1	2090	1	ZMYM2	13	20608481	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		20608481	94561397	252	17754										
SACS	26278	broad.mit.edu	37	chr13	23909330	23909330	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccattatcatcacgccacagGttccttctggctgaatccag	7	14	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:23909330G>A	uc001uon.2	-	10	9274	c.8685C>T	c.(8683-8685)AAC>AAT	p.N2895N	SACS_uc001uoo.2_Silent_p.N2748N|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2895					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CACGCCACAGGTTCCTTCTGG	0.433													0	0	0	0.00623	0	35	28										A	23909330	G	A	23909330	2	1	61	1	0	0	0	0	0	0	0	1	13804	1252	44	2		2	SACS	13	23909330	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3300849	23909330	91260548	253	17755										
SACS	26278	broad.mit.edu	37	chr13	23915753	23915753	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atcaattctctgccaggccaGaatgtattcattacttcctt	5	11	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:23915753G>A	uc001uon.2	-	10	2851	c.2262C>T	c.(2260-2262)TTC>TTT	p.F754F	SACS_uc001uoo.2_Silent_p.F607F|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Silent_p.F607F	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	754					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGCCAGGCCAGAATGTATTCA	0.373													0	0	0	0.009718	0	31	52										A	23915753	G	A	23915753	2	1	61	1	0	0	0	0	0	0	0	1	13804	933	33	1		1	SACS	13	23915753	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6423	23915753	91254125	254	17756										
C13orf26	122046	broad.mit.edu	37	chr13	31506889	31506889	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccagggctccggatccctctCtctgccaccacaacctccag	7	20	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:31506889C>T	uc001uti.2	+	1	56	c.37C>T	c.(37-39)CTC>TTC	p.L13F	uc001utg.1_5'Flank	NM_152325	NP_689538	Q8N6G2	CM026_HUMAN	hypothetical protein LOC122046	13										ovary(2)|skin(1)	3		Lung SC(185;0.0281)		all cancers(112;0.0176)|Epithelial(112;0.0768)|OV - Ovarian serous cystadenocarcinoma(117;0.0852)		GGATCCCTCTCTCTGCCACCA	0.672													0	0	0	0.007413	0	15	22										T	31506889	C	T	31506889	3	4	61	1	0	0	0	0	1	0	0	0	1722	913	32	1	39	1	C13orf26	13	31506889	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	7591136	31506889	83662989	255	17757										
RXFP2	122042	broad.mit.edu	37	chr13	32366994	32366994	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tactgacctacttgactttgGagaagttcctggtcattgtc	9	9	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:32366994G>C	uc001utt.2	+	16	1626	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q	RXFP2_uc010aba.2_Missense_Mutation_p.E478Q	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	519	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CTTGACTTTGGAGAAGTTCCT	0.517													0	0	0	0.003954	0	20	28										C	32366994	G	C	32366994	3	2	61	1	0	0	0	0	1	0	0	0	13760	1175	41	1	1617	1	RXFP2	13	32366994	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	860105	32366994	82802884	256	17758										
TRPC4	7223	broad.mit.edu	37	chr13	38225530	38225530	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaagggagtaggcagagtacCtccttcttcaaaataactca	9	9	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:38225530C>A	uc001uws.2	-	8	2186	c.1951G>T	c.(1951-1953)GGT>TGT	p.G651C	TRPC4_uc010abv.2_Missense_Mutation_p.G231C|TRPC4_uc001uwt.2_Missense_Mutation_p.G651C|TRPC4_uc010tey.1_Missense_Mutation_p.G651C|TRPC4_uc010abw.2_Missense_Mutation_p.G478C|TRPC4_uc010abx.2_Missense_Mutation_p.G651C|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	651	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GGCAGAGTACCTCCTTCTTCA	0.433													1	0	3.13765e-25	0.01441	3.40719e-25	60	47										A	38225530	C	A	38225530	3	1	61	1	0	0	0	0	1	0	0	0	16577	681	24	4	1013	4	TRPC4	13	38225530	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5858536	38225530	76944348	257	17759										
UTP14C	9724	broad.mit.edu	37	chr13	52603133	52603133	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggaaattggctgagaggtctGaggctagtctgaaagtgtca	15	5	3	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:52603133G>C	uc001vgb.2	+	2	728	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	UTP14C_uc001vga.2_3'UTR|UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	65					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TGAGAGGTCTGAGGCTAGTCT	0.468													0	0	0	0.01441	0	74	164										C	52603133	G	C	52603133	3	2	61	1	0	0	0	0	1	0	0	0	17093	1291	45	1	195	1	UTP14C	13	52603133	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14377603	52603133	62566745	258	17760										
TBC1D4	9882	broad.mit.edu	37	chr13	75933988	75933988	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gataaggttaatctcaaatcGcccaaccttaaaaataaaag	5	8	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:75933988G>A	uc001vjl.1	-	3	1434	c.1087C>T	c.(1087-1089)CGA>TGA	p.R363*	TBC1D4_uc010aer.2_Nonsense_Mutation_p.R363*|TBC1D4_uc010aes.2_Nonsense_Mutation_p.R363*	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	363	PID 2.					cytoplasm	Rab GTPase activator activity	p.R363Q(1)		ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		ATCTCAAATCGCCCAACCTTA	0.274													0	0	0	0.010729	0	11	38										A	75933988	G	A	75933988	4	1	61	1	0	0	0	0	0	1	0	0	15619	1095	38	2	2885	2	TBC1D4	13	75933988	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	23330855	75933988	39235890	259	17761										
MYCBP2	23077	broad.mit.edu	37	chr13	77667465	77667465	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccacaaaattttcatgatgaTgcctgcattaaatcaaaccc	4	11	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:77667465T>C	uc001vkf.2	-	60	10179	c.10088A>G	c.(10087-10089)CAT>CGT	p.H3363R	MYCBP2_uc010aev.2_Missense_Mutation_p.H2767R|MYCBP2_uc001vke.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTCATGATGATGCCTGCATTA	0.358													0	0	0	0.001984	0	7	127										C	77667465	T	C	77667465	3	2	61	1	0	0	0	0	1	0	0	0	10018	1464	51	5	3934	5	MYCBP2	13	77667465	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	1733477	77667465	37502413	260	17762										
DOCK9	23348	broad.mit.edu	37	chr13	99538841	99538841	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaactgcagcaaaggcgcttCttgtgaaaactggcccacca	9	12	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:99538841C>G	uc001vnt.2	-	19	2139	c.2084G>C	c.(2083-2085)AGA>ACA	p.R695T	DOCK9_uc001vnw.2_Missense_Mutation_p.R694T|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.R695T|DOCK9_uc010tis.1_Missense_Mutation_p.R694T|DOCK9_uc010tit.1_Missense_Mutation_p.R695T|DOCK9_uc010afu.1_Missense_Mutation_p.R510T	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	695	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AAAGGCGCTTCTTGTGAAAAC	0.383													0	0	0	0.007413	0	13	15										G	99538841	C	G	99538841	3	3	61	1	0	0	0	0	1	0	0	0	4694	913	32	1	4338	1	DOCK9	13	99538841	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	21871376	99538841	15631037	261	17763										
ARHGEF7	8874	broad.mit.edu	37	chr13	111929934	111929934	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatttctttttttgtattagGaaaagaatgaaagatatctt	7	2	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr13:111929934G>A	uc001vrs.2	+	14	1733	c.1483G>A	c.(1483-1485)GAA>AAA	p.E495K	ARHGEF7_uc001vrr.2_Missense_Mutation_p.E474K|ARHGEF7_uc001vrt.2_Missense_Mutation_p.E445K|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Missense_Mutation_p.E317K|ARHGEF7_uc001vrv.3_Missense_Mutation_p.E317K|ARHGEF7_uc001vrw.3_Missense_Mutation_p.E317K|ARHGEF7_uc001vrx.3_Missense_Mutation_p.E317K|ARHGEF7_uc010tjo.1_Missense_Mutation_p.E392K|ARHGEF7_uc010tjp.1_Missense_Mutation_p.E239K	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	495	PH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TTTGTATTAGGAAAAGAATGA	0.313													0	0	0	0.008291	0	9	19										A	111929934	G	A	111929934	3	1	61	1	0	0	0	0	1	0	0	0	911	1188	41	1	1537	1	ARHGEF7	13	111929934	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	12391093	111929934	3239944	262	17764										
TMEM63C	57156	broad.mit.edu	37	chr14	77709324	77709324	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcctcttcttcctcttcttCtttctcaccacgcctgccat	2	18	6	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:77709324C>G	uc001xtf.2	+	15	1478	c.1266C>G	c.(1264-1266)TTC>TTG	p.F422L	TMEM63C_uc010asq.1_Missense_Mutation_p.F422L	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	422	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		TCCTCTTCTTCTTTCTCACCA	0.552													0	0	0	0.010504	0	19	31										G	77709324	C	G	77709324	3	3	61	1	0	0	0	0	1	0	0	0	16189	912	32	1	1316	1	TMEM63C	14	77709324	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		77709324	29640216	263	17765										
SPTLC2	9517	broad.mit.edu	37	chr14	77984460	77984460	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	taattggggtggcaggaaatCcaaccacaacgacaccgatg	11	10	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:77984460C>G	uc001xub.2	-	11	1678	c.1490G>C	c.(1489-1491)GGA>GCA	p.G497A		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	497						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GGCAGGAAATCCAACCACAAC	0.483													0	0	0	0.004656	0	25	41										G	77984460	C	G	77984460	3	3	61	1	0	0	0	0	1	0	0	0	15123	855	30	1	206	1	SPTLC2	14	77984460	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	275136	77984460	29365080	264	17766										
TDP1	55775	broad.mit.edu	37	chr14	90437609	90437609	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccttacgagaacatctctctCtgccaggtaagccacttact	6	14	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:90437609C>T	uc001xxy.2	+	6	1049	c.750C>T	c.(748-750)CTC>CTT	p.L250L	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Silent_p.L250L|TDP1_uc010atn.2_Silent_p.L250L|TDP1_uc001xya.2_Missense_Mutation_p.S23F|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Silent_p.L250L	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	250					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		ACATCTCTCTCTGCCAGGTAA	0.378								Repair_of_DNA-protein_crosslinks					0	0	0	0.01441	0	41	29										T	90437609	C	T	90437609	2	4	61	1	0	0	0	0	0	0	0	1	15725	900	32	1		1	TDP1	14	90437609	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	12453149	90437609	16911931	265	17767										
SERPINA11	256394	broad.mit.edu	37	chr14	94914896	94914896	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctcactggcgagaagaagatGtttccgggggcgtctgctgc	15	10	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:94914896G>A	uc001ydd.1	-	2	276	c.216C>T	c.(214-216)AAC>AAT	p.N72N		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	72					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		AGAAGAAGATGTTTCCGGGGG	0.567													0	0	0	0.01441	0	82	107										A	94914896	G	A	94914896	2	1	61	1	0	0	0	0	0	0	0	1	14088	1368	48	2		2	SERPINA11	14	94914896	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4477287	94914896	12434644	266	17768										
PAPOLA	10914	broad.mit.edu	37	chr14	96991650	96991650	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attttttgtttcaacagaatCttccacaatctgtaattgaa	4	7	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:96991650C>G	uc001yfq.2	+	4	463	c.253C>G	c.(253-255)CTT>GTT	p.L85V	PAPOLA_uc001yfo.2_Missense_Mutation_p.L85V|PAPOLA_uc001yfp.2_Missense_Mutation_p.L85V|PAPOLA_uc001yfr.2_Missense_Mutation_p.L85V|PAPOLA_uc010twv.1_Missense_Mutation_p.L85V|PAPOLA_uc010avp.2_Translation_Start_Site	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	85					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		TCAACAGAATCTTCCACAATC	0.333													0	0	0	0.010504	0	15	31										G	96991650	C	G	96991650	3	3	61	1	0	0	0	0	1	0	0	0	11429	913	32	1	267	1	PAPOLA	14	96991650	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2076754	96991650	10357890	267	17769										
RTL1	388015	broad.mit.edu	37	chr14	101349286	101349286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acccacaggttcccaaggcgCggtggagggacactcgtaaa	13	12	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:101349286C>T	uc010txj.1	-	1	1899	c.1840G>A	c.(1840-1842)GCG>ACG	p.A614T	uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	614										pancreas(1)	1						TCCCAAGGCGCGGTGGAGGGA	0.552													0	0	0	0.010729	0	11	29										T	101349286	C	T	101349286	3	4	61	1	0	0	0	0	1	0	0	0	13724	768	27	2	2240	2	RTL1	14	101349286	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4357636	101349286	6000254	268	17770										
WDR20	91833	broad.mit.edu	37	chr14	102606455	102606455	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctggcaacggcgaccgcctCtgcttcaatgtgggccggga	14	13	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr14:102606455C>G	uc001ykz.2	+	1	244	c.195C>G	c.(193-195)CTC>CTG	p.L65L	WDR20_uc001yky.1_5'UTR|WDR20_uc001yla.2_5'UTR|WDR20_uc001ylb.2_Silent_p.L65L|WDR20_uc010txu.1_Silent_p.L65L|WDR20_uc001ylc.2_Silent_p.L65L|WDR20_uc001yld.2_Silent_p.L65L|WDR20_uc001yle.2_Silent_p.L65L|WDR20_uc001ylf.2_Silent_p.L65L|HSP90AA1_uc001ykv.3_5'Flank	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	65											0						GCGACCGCCTCTGCTTCAATG	0.637													0	0	0	0.007291	0	25	25										G	102606455	C	G	102606455	2	3	61	1	0	0	0	0	0	0	0	1	17277	900	32	1		1	WDR20	14	102606455	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1257169	102606455	4743085	269	17771										
SLC12A6	9990	broad.mit.edu	37	chr15	34544565	34544565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtgtcttgatgaaagggtgCggttacccagcatgcagacc	13	9	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:34544565C>T	uc001zhw.2	-	9	1303	c.1139G>A	c.(1138-1140)CGC>CAC	p.R380H	SLC12A6_uc001zhv.2_Missense_Mutation_p.R329H|SLC12A6_uc001zhx.2_Missense_Mutation_p.R365H|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.R321H|SLC12A6_uc001zib.2_Missense_Mutation_p.R371H|SLC12A6_uc001zic.2_Missense_Mutation_p.R380H|SLC12A6_uc010bau.2_Missense_Mutation_p.R380H|SLC12A6_uc001zid.2_Missense_Mutation_p.R321H|SLC12A6_uc001zht.2_5'Flank|SLC12A6_uc001zhu.2_Missense_Mutation_p.R192H	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	380	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	TGAAAGGGTGCGGTTACCCAG	0.383													0	0	0	0.007291	0	23	40										T	34544565	C	T	34544565	3	4	61	1	0	0	0	0	1	0	0	0	14387	768	27	2	2381	2	SLC12A6	15	34544565	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		34544565	67986827	270	17772										
OIP5	11339	broad.mit.edu	37	chr15	41624731	41624731	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggggcggcgttgcacaacgtGagcgatgccgcagcggctga	18	11	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:41624731G>C	uc001znp.2	-	1	89	c.29C>G	c.(28-30)TCA>TGA	p.S10*	NUSAP1_uc001znq.3_5'Flank|NUSAP1_uc001znr.3_5'Flank|NUSAP1_uc001zns.3_5'Flank|NUSAP1_uc010bce.2_5'Flank|NUSAP1_uc001znt.3_5'Flank|NUSAP1_uc001znv.3_5'Flank|NUSAP1_uc001znu.3_5'Flank|NUSAP1_uc010ucw.1_5'Flank	NM_007280	NP_009211	O43482	MS18B_HUMAN	Opa interacting protein 5	10					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		TGCACAACGTGAGCGATGCCG	0.637													0	0	0	0.01441	0	59	62										C	41624731	G	C	41624731	4	2	61	1	0	0	0	0	0	1	0	0	10848	1294	45	1	680	1	OIP5	15	41624731	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7080166	41624731	60906661	271	17773										
RTF1	23168	broad.mit.edu	37	chr15	41763545	41763545	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acaacagcaaaccagtttacCgggttggtatttcttccctt	7	11	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:41763545C>T	uc001zny.2	+	8	1213	c.1201C>T	c.(1201-1203)CGG>TGG	p.R401W		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	401	Plus3.			R->E: Loss of binding to single-stranded DNA.	histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		ACCAGTTTACCGGGTTGGTAT	0.443													0	0	0	0.007291	0	27	31										T	41763545	C	T	41763545	3	4	61	1	0	0	0	0	1	0	0	0	13721	643	23	2	1231	2	RTF1	15	41763545	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	138814	41763545	60767847	272	17774										
PDIA3	2923	broad.mit.edu	37	chr15	44057680	44057680	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atttcgtccttcacatctcaCtaacaagtttgaggacaaga	6	10	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:44057680C>G	uc001zsu.2	+	6	783	c.635C>G	c.(634-636)ACT>AGT	p.T212S	PDIA3_uc010bdp.2_Missense_Mutation_p.T192S|PDIA3_uc010ued.1_5'UTR	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	212					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		TCACATCTCACTAACAAGTTT	0.348													0	0	0	0.005524	0	33	46										G	44057680	C	G	44057680	3	3	61	1	0	0	0	0	1	0	0	0	11669	565	20	4	657	4	PDIA3	15	44057680	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2294135	44057680	58473712	273	17775										
SLC27A2	11001	broad.mit.edu	37	chr15	50519256	50519256	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggagcaaaggctcagacagaGaagaaaaaactgagagatgt	13	5	1	5			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:50519256G>C	uc001zxw.2	+	7	1570	c.1338G>C	c.(1336-1338)GAG>GAC	p.E446D	SLC27A2_uc010bes.2_Missense_Mutation_p.E393D|SLC27A2_uc001zxx.2_Missense_Mutation_p.E211D	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	446	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CTCAGACAGAGAAGAAAAAAC	0.383													0	0	0	0.008291	0	10	13										C	50519256	G	C	50519256	3	2	61	1	0	0	0	0	1	0	0	0	14526	933	33	1	1364	1	SLC27A2	15	50519256	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6461576	50519256	52012136	274	17776										
TMOD2	29767	broad.mit.edu	37	chr15	52090495	52090495	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctggccctggtagaggcactGaaagaaaatgacaccttgac	11	10	0	5			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:52090495G>A	uc002abk.2	+	8	1055	c.834G>A	c.(832-834)CTG>CTA	p.L278L	TMOD2_uc002abl.3_Silent_p.L242L|TMOD2_uc010bfb.2_Silent_p.L234L	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	278					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		TAGAGGCACTGAAAGAAAATG	0.453													0	0	0	0.013537	0	9	22										A	52090495	G	A	52090495	2	1	61	1	0	0	0	0	0	0	0	1	16231	1277	45	1		1	TMOD2	15	52090495	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1571239	52090495	50440897	275	17777										
HERC1	8925	broad.mit.edu	37	chr15	64048748	64048748	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgaagacttctccttctgtcGtaaaggctaaagtgtgacca	9	9	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:64048748G>A	uc002amp.2	-	5	1569	c.1421C>T	c.(1420-1422)ACG>ATG	p.T474M	HERC1_uc010uil.1_Intron|HERC1_uc010bgt.1_Missense_Mutation_p.T474M	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	474	WD 1.|RCC1 2.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCCTTCTGTCGTAAAGGCTAA	0.393													0	0	0	0.012213	0	31	29										A	64048748	G	A	64048748	3	1	61	1	0	0	0	0	1	0	0	0	7057	1145	40	2	13460	2	HERC1	15	64048748	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	11958253	64048748	38482644	276	17778										
DENND4A	10260	broad.mit.edu	37	chr15	65982875	65982875	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttaggtactagtagtgtatCtaagttaaatgaaggtgatg	11	2	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:65982875C>G	uc002aph.2	-	22	4303	c.3925G>C	c.(3925-3927)GAT>CAT	p.D1309H	DENND4A_uc002api.2_Missense_Mutation_p.D1352H|DENND4A_uc002apj.3_Missense_Mutation_p.D1309H	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AGTAGTGTATCTAAGTTAAAT	0.398													0	0	0	0.010818	0	23	32										G	65982875	C	G	65982875	3	3	61	1	0	0	0	0	1	0	0	0	4433	913	32	1	1710	1	DENND4A	15	65982875	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1934127	65982875	36548517	277	17779										
ITGA11	22801	broad.mit.edu	37	chr15	68649618	68649618	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	actcatgcaccacatcttcgCcatactgcacaactccaacc	3	18	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:68649618C>G	uc002ari.2	-	7	707	c.620G>C	c.(619-621)GGC>GCC	p.G207A	ITGA11_uc010bib.2_Missense_Mutation_p.G207A	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	207	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CACATCTTCGCCATACTGCAC	0.507													0	0	0	0.01441	0	43	59										G	68649618	C	G	68649618	3	3	61	1	0	0	0	0	1	0	0	0	7874	739	26	4	3042	4	ITGA11	15	68649618	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2666743	68649618	33881774	278	17780										
SIN3A	25942	broad.mit.edu	37	chr15	75668200	75668200	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	accacgttgacacttccggaTccgccgtagattcctattgc	8	14	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:75668200T>C	uc002bai.2	-	20	3656	c.3397A>G	c.(3397-3399)ATC>GTC	p.I1133V	SIN3A_uc002baj.2_Missense_Mutation_p.I1133V|SIN3A_uc010uml.1_Missense_Mutation_p.I1133V	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1133					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						CACTTCCGGATCCGCCGTAGA	0.493													0	0	0	0.01441	0	19	95										C	75668200	T	C	75668200	3	2	61	1	0	0	0	0	1	0	0	0	14325	1435	50	5	432	5	SIN3A	15	75668200	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	7018582	75668200	26863192	279	17781										
SIN3A	25942	broad.mit.edu	37	chr15	75676654	75676654	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gctcagctttccgctgatacGttgactccaggaggctcctt	10	13	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:75676654G>T	uc002bai.2	-	17	3405	c.3146C>A	c.(3145-3147)ACG>AAG	p.T1049K	SIN3A_uc002baj.2_Missense_Mutation_p.T1049K|SIN3A_uc010uml.1_Missense_Mutation_p.T1049K	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1049					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						CCGCTGATACGTTGACTCCAG	0.493													1	0	4.1943e-16	0.008291	4.44686e-16	8	144										T	75676654	G	T	75676654	3	4	61	1	0	0	0	0	1	0	0	0	14325	1145	40	4	695	4	SIN3A	15	75676654	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	8454	75676654	26854738	280	17782										
PTPN9	5780	broad.mit.edu	37	chr15	75798201	75798201	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagaacaggatgatctcatcGaagggatctgggtggccgtt	15	7	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:75798201G>A	uc002bal.2	-	7	1291	c.783C>T	c.(781-783)TTC>TTT	p.F261F		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	261						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						TGATCTCATCGAAGGGATCTG	0.527													0	0	0	0.005443	0	23	46										A	75798201	G	A	75798201	2	1	61	1	0	0	0	0	0	0	0	1	12794	1049	37	1		1	PTPN9	15	75798201	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	121547	75798201	26733191	281	17783										
ACAN	176	broad.mit.edu	37	chr15	89398558	89398558	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtgggctcaggcctgcctgtGgaaagtggactaccctcagg	15	11	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:89398558G>A	uc010upo.1	+	12	3116	c.2742G>A	c.(2740-2742)GTG>GTA	p.V914V	ACAN_uc010upp.1_Silent_p.V914V|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	914					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GCCTGCCTGTGGAAAGTGGAC	0.587													0	0	0	0.003163	0	12	16										A	89398558	G	A	89398558	2	1	61	1	0	0	0	0	0	0	0	1	117	1335	47	2		2	ACAN	15	89398558	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	13600357	89398558	13132834	282	17784										
IQGAP1	8826	broad.mit.edu	37	chr15	91025471	91025471	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaagtgctgaaggactcgttGcatgagaagttccctgatgc	12	8	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr15:91025471G>A	uc002bpl.1	+	28	3614	c.3513G>A	c.(3511-3513)TTG>TTA	p.L1171L		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1171	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AGGACTCGTTGCATGAGAAGT	0.502											OREG0023473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	41	65										A	91025471	G	A	91025471	2	1	61	1	0	0	0	0	0	0	0	1	7814	1310	46	2		2	IQGAP1	15	91025471	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1626913	91025471	11505921	283	17785										
CHTF18	63922	broad.mit.edu	37	chr16	847068	847068	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagcggctggagcacatcatGaggcgagcggcccgggagga	18	11	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:847068G>C	uc002cke.3	+	20	2772	c.2709G>C	c.(2707-2709)ATG>ATC	p.M903I	CHTF18_uc002ckf.3_Missense_Mutation_p.M931I|CHTF18_uc010brf.2_Missense_Mutation_p.M485I|CHTF18_uc002ckg.3_Missense_Mutation_p.M421I	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	903					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				AGCACATCATGAGGCGAGCGG	0.672													0	0	0	0.01441	0	43	48										C	847068	G	C	847068	3	2	61	1	0	0	0	0	1	0	0	0	3414	1290	45	1	2787	1	CHTF18	16	847068	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		847068	89507685	284	17786										
TPSAB1	7177	broad.mit.edu	37	chr16	1291238	1291238	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gccctggcaggtgagcctgaGagtccacggcccatactgga	14	13	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:1291238G>C	uc002ckz.2	+	3	198	c.146G>C	c.(145-147)AGA>ACA	p.R49T	TPSAB1_uc010uux.1_5'UTR	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	49	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GTGAGCCTGAGAGTCCACGGC	0.706													0	0	0	0.010818	0	27	55										C	1291238	G	C	1291238	3	2	61	1	0	0	0	0	1	0	0	0	16420	942	33	1	152	1	TPSAB1	16	1291238	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	444170	1291238	89063515	285	17787										
SYNGR3	9143	broad.mit.edu	37	chr16	2042986	2042986	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggctatccggtgggcagcggCgtggagggcaccgagaccta	18	11	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:2042986C>T	uc002cod.2	+	4	739	c.603C>T	c.(601-603)GGC>GGT	p.G201G		NM_004209	NP_004200	O43761	SNG3_HUMAN	synaptogyrin 3	201					positive regulation of transporter activity	cell junction|integral to plasma membrane|synaptic vesicle					0						TGGGCAGCGGCGTGGAGGGCA	0.692													0	0	0	0.008871	0	13	26										T	2042986	C	T	2042986	2	4	61	1	0	0	0	0	0	0	0	1	15447	755	27	2		2	SYNGR3	16	2042986	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	751748	2042986	88311767	286	17788										
ZNF200	7752	broad.mit.edu	37	chr16	3274554	3274554	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgaagacttttctctataatCttcattttctacaggttccc	4	10	4	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:3274554C>G	uc002cuj.2	-	5	1158	c.526G>C	c.(526-528)GAT>CAT	p.D176H	ZNF200_uc002cum.3_Missense_Mutation_p.D175H|ZNF200_uc010bti.2_Missense_Mutation_p.D175H|ZNF200_uc002cuk.2_Missense_Mutation_p.D176H|ZNF200_uc002cui.2_Missense_Mutation_p.D175H|ZNF200_uc002cul.3_Missense_Mutation_p.D175H	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TCTCTATAATCTTCATTTTCT	0.398													0	0	0	0.004672	0	3	41										G	3274554	C	G	3274554	3	3	61	1	0	0	0	0	1	0	0	0	17759	913	32	1	665	1	ZNF200	16	3274554	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1231568	3274554	87080199	287	17789										
PPL	5493	broad.mit.edu	37	chr16	4938143	4938143	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caggagattggagcctggctCtcttgctcacgtggcttctc	12	12	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:4938143C>T	uc002cyd.1	-	20	2564	c.2474G>A	c.(2473-2475)AGA>AAA	p.R825K		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	825	Spectrin 4.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GAGCCTGGCTCTCTTGCTCAC	0.562													0	0	0	0.01441	0	41	41										T	4938143	C	T	4938143	3	4	61	1	0	0	0	0	1	0	0	0	12334	913	32	1	2808	1	PPL	16	4938143	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1663589	4938143	85416610	288	17790										
NOMO1	23420	broad.mit.edu	37	chr16	14969017	14969017	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agagggagaaaaacggcaatGaggaaggcgaagaaagaatg	16	3	0	5			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:14969017G>A	uc002dcv.2	+	19	2245	c.2179G>A	c.(2179-2181)GAG>AAG	p.E727K		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	727	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						AAACGGCAATGAGGAAGGCGA	0.567													0	0	0	0.01441	0	78	169										A	14969017	G	A	14969017	3	1	61	1	0	0	0	0	1	0	0	0	10531	1291	45	1	2253	1	NOMO1	16	14969017	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	10030874	14969017	75385736	289	17791										
DNAH3	55567	broad.mit.edu	37	chr16	20990840	20990840	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgacagcttcttgacgctctCttggaaatatttgcacatgg	9	9	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:20990840C>G	uc010vbe.1	-	50	7888	c.7888G>C	c.(7888-7890)GAG>CAG	p.E2630Q	DNAH3_uc010vbd.1_Missense_Mutation_p.E65Q	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2630	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGACGCTCTCTTGGAAATAT	0.463													0	0	0	0.01441	0	42	51										G	20990840	C	G	20990840	3	3	61	1	0	0	0	0	1	0	0	0	4603	922	32	1	4513	1	DNAH3	16	20990840	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	6021823	20990840	69363913	290	17792										
ITGAX	3687	broad.mit.edu	37	chr16	31383090	31383090	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aaggcacactgtgaaaacttCaacctgctgctcccggtgcg	10	13	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:31383090C>T	uc002ebu.1	+	17	2212	c.2145C>T	c.(2143-2145)TTC>TTT	p.F715F	ITGAX_uc002ebt.2_Silent_p.F715F	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	715	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTGAAAACTTCAACCTGCTGC	0.542													0	0	0	0.003271	0	24	35										T	31383090	C	T	31383090	2	4	61	1	0	0	0	0	0	0	0	1	7889	825	29	1		1	ITGAX	16	31383090	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	10392250	31383090	58971663	291	17793										
DYNC1LI2	1783	broad.mit.edu	37	chr16	66766331	66766331	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atatacttatacaacaagtcGaggtttttctcttctttcac	4	9	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:66766331G>C	uc002eqb.1	-	7	871	c.840C>G	c.(838-840)CTC>CTG	p.L280L	DYNC1LI2_uc010vis.1_Silent_p.L203L|DYNC1LI2_uc010vit.1_Silent_p.L280L|DYNC1LI2_uc010viu.1_Silent_p.L241L	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	280					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		ACAACAAGTCGAGGTTTTTCT	0.373													0	0	0	0.008291	0	10	23										C	66766331	G	C	66766331	2	2	61	1	0	0	0	0	0	0	0	1	4845	1045	37	1		1	DYNC1LI2	16	66766331	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	35383241	66766331	23588422	292	17794										
TMEM231	79583	broad.mit.edu	37	chr16	75579280	75579280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcatctaggccaccacagctCagcggctgcttctgctgcag	11	15	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:75579280C>T	uc002fem.2	-	4	615	c.552G>A	c.(550-552)CTG>CTA	p.L184L	CHST5_uc002fej.1_5'UTR|TMEM231_uc002fek.2_Silent_p.L213L|TMEM231_uc002fel.2_Silent_p.L68L|TMEM231_uc010vne.1_Silent_p.L37L|TMEM231_uc010cgx.1_Silent_p.L148L	NM_001077418	NP_001070886	Q9H6L2	TM231_HUMAN	transmembrane protein 231 isoform 2	184						integral to membrane					0						CACCACAGCTCAGCGGCTGCT	0.517													0	0	0	0.01441	0	46	72										T	75579280	C	T	75579280	2	4	61	1	0	0	0	0	0	0	0	1	16146	813	29	1		1	TMEM231	16	75579280	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8812949	75579280	14775473	293	17795										
USP10	9100	broad.mit.edu	37	chr16	84778635	84778635	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggtcaatggccatgccaattCagcagtcccgaacagtgtca	10	12	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:84778635C>T	uc002fii.2	+	4	690	c.548C>T	c.(547-549)TCA>TTA	p.S183L	USP10_uc010voe.1_Missense_Mutation_p.S187L|USP10_uc010vof.1_Intron|USP10_uc002fij.2_5'UTR	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	183					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						CATGCCAATTCAGCAGTCCCG	0.498													0	0	0	0.01441	0	35	38										T	84778635	C	T	84778635	3	4	61	1	0	0	0	0	1	0	0	0	17038	838	29	1	562	1	USP10	16	84778635	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	9199355	84778635	5576118	294	17796										
FOXF1	2294	broad.mit.edu	37	chr16	86544388	86544388	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cccaccaagcgcctgacgctGagcgagatctaccagttcct	9	16	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr16:86544388G>A	uc002fjl.2	+	1	256	c.213G>A	c.(211-213)CTG>CTA	p.L71L	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	71	Fork-head.				branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						GCCTGACGCTGAGCGAGATCT	0.627													0	0	0	0.013114	0	37	27										A	86544388	G	A	86544388	2	1	61	1	0	0	0	0	0	0	0	1	6005	1277	45	1		1	FOXF1	16	86544388	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1765753	86544388	3810365	295	17797										
OR3A2	4995	broad.mit.edu	37	chr17	3181494	3181494	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggagccacacgtggagaaggCcttctttcggccctccactg	12	14	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:3181494C>T	uc002fvg.2	-	1	775	c.736G>A	c.(736-738)GCC>ACC	p.A246T		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	246	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GTGGAGAAGGCCTTCTTTCGG	0.517													0	0	0	0.001855	0	10	16										T	3181494	C	T	3181494	3	4	61	1	0	0	0	0	1	0	0	0	11038	739	26	2	233	2	OR3A2	17	3181494	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		3181494	78013716	296	17798										
TP53	7157	broad.mit.edu	37	chr17	7577562	7577563	+	Frame_Shift_Ins	INS	-	-	T													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	catgccgcccatgcaggaacINStgttacacatgtagttgtag							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:7577562_7577563insT	uc002gim.2	-	7	912_913	c.718_719insA	c.(718-720)AGTfs	p.S240fs	TP53_uc002gig.1_Frame_Shift_Ins_p.S240fs|TP53_uc002gih.2_Frame_Shift_Ins_p.S240fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.S108fs|TP53_uc010cng.1_Frame_Shift_Ins_p.S108fs|TP53_uc002gii.1_Frame_Shift_Ins_p.S108fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.S240fs|TP53_uc010cni.1_Frame_Shift_Ins_p.S240fs|TP53_uc002gij.2_Frame_Shift_Ins_p.S240fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Ins_p.S147fs|TP53_uc002gio.2_Frame_Shift_Ins_p.S108fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	240	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> T (in sporadic cancers; somatic mutation).|S -> P (in a sporadic cancer; somatic mutation).|S -> N (in sporadic cancers; somatic mutation).|S -> G (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> R (in sporadic cancers; somatic mutation).|S -> I (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S240G(14)|p.S240R(8)|p.0?(7)|p.S240I(6)|p.N239_C242delNSSC(3)|p.S240C(3)|p.N239_S240insX(2)|p.S240S(2)|p.S240T(2)|p.S240fs*7(2)|p.N239_S240delNS(2)|p.Y236_M243delYMCNSSCM(1)|p.N239_S240insN(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.S240>CSC(1)|p.C238_M246delCNSSCMGGM(1)|p.S240P(1)|p.H233_C242del10(1)|p.C238fs*21(1)|p.H233fs*6(1)|p.S240fs*26(1)|p.S240fs*23(1)|p.N239_C242>S(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGCAGGAACTGTTACACATG	0.574		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)								71	19	---	---								T	7577563	-	T	7577562	7	5	61	1	0	1	1	0	0	0	0	0	16378	565	20	0	571	0	TP53	17	7577562	Frame_Shift_Ins	INS	-	TCGA-DK-A3IS-01A-21D-A21A-08	4396068	7577562	73617648	297	17799										
CHD3	1107	broad.mit.edu	37	chr17	7797534	7797534	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggccggcctgatggccctgtCcgcaccaagaaactaaagag	12	13	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:7797534C>T	uc002gje.2	+	7	1176	c.1026C>T	c.(1024-1026)GTC>GTT	p.V342V	CHD3_uc002gjd.2_Silent_p.V401V|CHD3_uc002gjf.2_Silent_p.V342V|CHD3_uc002gjg.1_Silent_p.V170V	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	342					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				ATGGCCCTGTCCGCACCAAGA	0.557													0	0	0	0.007413	0	20	4										T	7797534	C	T	7797534	2	4	61	1	0	0	0	0	0	0	0	1	3326	842	30	1		1	CHD3	17	7797534	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	219972	7797534	73397676	298	17800										
UBB	7314	broad.mit.edu	37	chr17	16285453	16285453	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcgtctgagaggtggtatgCagatcttcgtgaagaccctg	14	8	2	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:16285453C>A	uc002gpx.2	+	2	370	c.232C>A	c.(232-234)CAG>AAG	p.Q78K	UBB_uc010vwe.1_Intron	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	78	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGGTGGTATGCAGATCTTCGT	0.537													1	0	6.4e-05	0.004672	6.57333e-05	3	41										A	16285453	C	A	16285453	3	1	61	1	0	0	0	0	1	0	0	0	16838	711	25	4	234	4	UBB	17	16285453	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	8487919	16285453	64909757	299	17801										
UBB	7314	broad.mit.edu	37	chr17	16285681	16285681	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcgtctgagaggtggtatgCagatcttcgtgaagaccctg	14	8	2	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:16285681C>A	uc002gpx.2	+	2	598	c.460C>A	c.(460-462)CAG>AAG	p.Q154K	UBB_uc010vwe.1_Missense_Mutation_p.Q78K	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	154	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGGTGGTATGCAGATCTTCGT	0.537													1	0	6.4e-05	0.004672	6.57333e-05	3	47										A	16285681	C	A	16285681	3	1	61	1	0	0	0	0	1	0	0	0	16838	711	25	4	462	4	UBB	17	16285681	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	228	16285681	64909529	300	17802										
KCNJ12	3768	broad.mit.edu	37	chr17	21319000	21319000	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acggtgacctggagccggctGagggccggggccgcacaccc	17	15	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:21319000G>A	uc002gyv.1	+	3	1051	c.346G>A	c.(346-348)GAG>AAG	p.E116K		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	116	Extracellular (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GGAGCCGGCTGAGGGCCGGGG	0.647										Prostate(3;0.18)			0	0	0	0.00499	0	13	46										A	21319000	G	A	21319000	3	1	61	1	0	0	0	0	1	0	0	0	8046	1291	45	1	348	1	KCNJ12	17	21319000	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5033319	21319000	59876210	301	17803										
GIT1	28964	broad.mit.edu	37	chr17	27903633	27903633	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatgtagccagggccttcttCagctccaggtactcctgcag	11	13	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:27903633C>T	uc002hef.2	-	13	1501	c.1287G>A	c.(1285-1287)CTG>CTA	p.L429L	GIT1_uc002heg.2_Silent_p.L438L|GIT1_uc010wbg.1_Silent_p.L438L|GIT1_uc010csb.1_Silent_p.L429L	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	429					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GGGCCTTCTTCAGCTCCAGGT	0.617													0	0	0	0.005443	0	25	30										T	27903633	C	T	27903633	2	4	61	1	0	0	0	0	0	0	0	1	6396	813	29	1		1	GIT1	17	27903633	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	6584633	27903633	53291577	302	17804										
CORO6	84940	broad.mit.edu	37	chr17	27946116	27946116	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcctggcagtagggtgccagGagaggatgcccacacgcttg	15	11	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:27946116G>C	uc002hel.2	-	3	415	c.413C>G	c.(412-414)TCC>TGC	p.S138C	CORO6_uc002hem.2_5'Flank|CORO6_uc002hen.2_5'Flank	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	138	WD 2.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						AGGGTGCCAGGAGAGGATGCC	0.597													0	0	0	0.003954	0	26	31										C	27946116	G	C	27946116	3	2	61	1	0	0	0	0	1	0	0	0	3758	1174	41	1	1037	1	CORO6	17	27946116	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	42483	27946116	53249094	303	17805										
LYZL6	57151	broad.mit.edu	37	chr17	34261801	34261801	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggtgcacccgcaccctgtttCatctcaggcggcatcctgtc	10	16	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:34261801C>T	uc002hkj.1	-	4	596	c.446G>A	c.(445-447)TGA>TAA	p.*149*	LYZL6_uc002hkk.1_Silent_p.*149*	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	149					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CACCCTGTTTCATCTCAGGCG	0.512													0	0	0	0.01441	0	40	53										T	34261801	C	T	34261801	2	4	61	1	0	0	0	0	0	0	0	1	9134	837	29	1		1	LYZL6	17	34261801	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	6315685	34261801	46933409	304	17806										
TBC1D3B	414059	broad.mit.edu	37	chr17	34499268	34499268	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tccttaatgtcccgcttatgTcccggtcgatgcgctggatg	11	12	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:34499268T>C	uc002hky.2	-	7	593	c.443A>G	c.(442-444)GAC>GGC	p.D148G	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	148	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCCGCTTATGTCCCGGTCGAT	0.547													0	0	0	0.01441	0	24	358										C	34499268	T	C	34499268	3	2	61	1	0	0	0	0	1	0	0	0	15617	1667	58	5	1238	5	TBC1D3B	17	34499268	Missense_Mutation	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	237467	34499268	46695942	305	17807										
GGNBP2	79893	broad.mit.edu	37	chr17	34910697	34910697	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgataatgtgttaaatctcGatggacatcagaataatggt	9	5	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:34910697G>A	uc002hnb.2	+	3	379	c.130G>A	c.(130-132)GAT>AAT	p.D44N	GGNBP2_uc002hna.2_Missense_Mutation_p.D44N	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	44					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GTTAAATCTCGATGGACATCA	0.348													0	0	0	0.01441	0	69	94										A	34910697	G	A	34910697	3	1	61	1	0	0	0	0	1	0	0	0	6359	1058	37	1	136	1	GGNBP2	17	34910697	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	411429	34910697	46284513	306	17808										
PIP4K2B	8396	broad.mit.edu	37	chr17	36955630	36955630	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtcttggtcttgctggcgctGagcggcgccaccgccaccgc	14	16	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:36955630G>C	uc002hqs.2	-	1	529	c.48C>G	c.(46-48)CTC>CTG	p.L16L	PIP4K2B_uc010wdt.1_Silent_p.L16L	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	16					cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						TGCTGGCGCTGAGCGGCGCCA	0.557													0	0	0	0.004007	0	14	20										C	36955630	G	C	36955630	2	2	61	1	0	0	0	0	0	0	0	1	11937	1277	45	1		1	PIP4K2B	17	36955630	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2044933	36955630	44239580	307	17809										
MED1	5469	broad.mit.edu	37	chr17	37564544	37564544	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctggtgacaaccccatgcttCagtttatctatgacagctgt	8	11	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:37564544C>T	uc002hrv.3	-	17	4142	c.3930G>A	c.(3928-3930)CTG>CTA	p.L1310L	MED1_uc010wee.1_Silent_p.L1138L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1310	Ser-rich.|Interaction with TP53.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CCCCATGCTTCAGTTTATCTA	0.522										HNSCC(31;0.082)			0	0	0	0.01441	0	44	61										T	37564544	C	T	37564544	2	4	61	1	0	0	0	0	0	0	0	1	9425	813	29	1		1	MED1	17	37564544	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	608914	37564544	43630666	308	17810										
ERBB2	2064	broad.mit.edu	37	chr17	37879820	37879820	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccgctgacacctagcggagcGatgcccaaccaggcgcagat	12	15	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:37879820G>A	uc002hso.2	+	18	2353	c.2115G>A	c.(2113-2115)GCG>GCA	p.A705A	ERBB2_uc002hsm.2_Silent_p.A675A|ERBB2_uc010cwa.2_Silent_p.A690A|ERBB2_uc002hsp.2_Silent_p.A508A|ERBB2_uc010cwb.2_Silent_p.A705A|ERBB2_uc010wek.1_Silent_p.A429A	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	705	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CTAGCGGAGCGATGCCCAACC	0.652		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.00308	0	6	8										A	37879820	G	A	37879820	2	1	61	1	0	0	0	0	0	0	0	1	5206	1045	37	1		1	ERBB2	17	37879820	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	315276	37879820	43315390	309	17811										
RAPGEFL1	51195	broad.mit.edu	37	chr17	38345517	38345517	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaccatacgcagccgcctttCagcatctgtgcaggacattc	9	14	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:38345517C>T	uc010cwu.1	+	6	876	c.386C>T	c.(385-387)TCA>TTA	p.S129L	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.S65L	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	335					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AGCCGCCTTTCAGCATCTGTG	0.537													0	0	0	0.006214	0	9	246										T	38345517	C	T	38345517	3	4	61	1	0	0	0	0	1	0	0	0	13049	838	29	1	400	1	RAPGEFL1	17	38345517	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	465697	38345517	42849693	310	17812										
KRT20	54474	broad.mit.edu	37	chr17	39041067	39041067	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctgacttcgcagctcttcaAtttgtctgtaatatgcactg	7	11	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:39041067A>G	uc002hvl.2	-	1	413	c.371T>C	c.(370-372)ATT>ACT	p.I124T		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	124	Coil 1B.|Rod.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				CAGCTCTTCAATTTGTCTGTA	0.458													0	0	0	0.01441	0	38	58										G	39041067	A	G	39041067	3	3	61	1	0	0	0	0	1	0	0	0	8458	101	4	5	935	5	KRT20	17	39041067	Missense_Mutation	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	695550	39041067	42154143	311	17813										
STAT5B	6777	broad.mit.edu	37	chr17	40370258	40370258	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggggggttcatgtgcacgttCagcttcccgcccaccagcag	13	14	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:40370258C>T	uc002hzh.2	-	9	1249	c.1080G>A	c.(1078-1080)CTG>CTA	p.L360L	STAT5B_uc002hzi.3_Silent_p.L360L	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	360					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TGTGCACGTTCAGCTTCCCGC	0.577													0	0	0	0.000602	0	5	105										T	40370258	C	T	40370258	2	4	61	1	0	0	0	0	0	0	0	1	15268	813	29	1		1	STAT5B	17	40370258	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1329191	40370258	40824952	312	17814										
NBR1	4077	broad.mit.edu	37	chr17	41345231	41345231	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttatcaaacactggaggatGaaaaatacaggaaatgtaaa	8	4	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:41345231G>A	uc010czd.2	+	11	1334	c.1194G>A	c.(1192-1194)ATG>ATA	p.M398I	NBR1_uc010diz.2_Missense_Mutation_p.M398I|NBR1_uc010whu.1_Missense_Mutation_p.M398I|NBR1_uc010whv.1_Missense_Mutation_p.M398I|NBR1_uc010whw.1_Missense_Mutation_p.M377I|NBR1_uc010whx.1_Missense_Mutation_p.M207I	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	398					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		ACTGGAGGATGAAAAATACAG	0.443													0	0	0	0.006214	0	9	21										A	41345231	G	A	41345231	3	1	61	1	0	0	0	0	1	0	0	0	10200	1290	45	1	1232	1	NBR1	17	41345231	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	974973	41345231	39849979	313	17815										
ETV4	2118	broad.mit.edu	37	chr17	41606896	41606896	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcaggctcaatgagcttgaaCtccattccccggcccgtcca	8	16	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:41606896C>T	uc002idw.2	-	11	1232	c.1104G>A	c.(1102-1104)GAG>GAA	p.E368E	ETV4_uc002idv.2_Silent_p.E91E|ETV4_uc010wih.1_Silent_p.E314E|ETV4_uc010czh.2_Silent_p.E367E|ETV4_uc010wii.1_Silent_p.E329E|ETV4_uc002idx.2_Silent_p.E368E|ETV4_uc010wij.1_Silent_p.E329E	NM_001986	NP_001977	P43268	ETV4_HUMAN	ets variant gene 4 (E1A enhancer binding	368	ETS.				positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)	bone(4)|soft_tissue(2)|ovary(1)	7		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		TGAGCTTGAACTCCATTCCCC	0.587			T	EWSR1|TMPRSS2|DDX5|KLK2|CANT1	Ewing sarcoma|Prostate carcinoma								0	0	0	0.008361	0	28	38										T	41606896	C	T	41606896	2	4	61	1	0	0	0	0	0	0	0	1	5281	564	20	2		2	ETV4	17	41606896	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	261665	41606896	39588314	314	17816										
CRHR1	1394	broad.mit.edu	37	chr17	43912040	43912040	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cggtggcaggacaagcactcGatccgtgcccgagtggcccg	15	14	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:43912040G>A	uc010dap.2	+	14	1510	c.1245G>A	c.(1243-1245)TCG>TCA	p.S415S	CRHR1_uc010wjx.1_Silent_p.S211S|CRHR1_uc002ijp.2_Missense_Mutation_p.R240Q|CRHR1_uc002ijm.2_Silent_p.S386S|CRHR1_uc002ijn.2_Silent_p.S346S|CRHR1_uc010dar.2_Silent_p.S372S|CRHR1_uc010dao.2_Silent_p.S285S|CRHR1_uc010daq.2_Silent_p.S211S	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	415	Cytoplasmic (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		ACAAGCACTCGATCCGTGCCC	0.637													0	0	0	0.01441	0	55	58										A	43912040	G	A	43912040	2	1	61	1	0	0	0	0	0	0	0	1	3871	1045	37	1		1	CRHR1	17	43912040	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2305144	43912040	37283170	315	17817										
FAM117A	81558	broad.mit.edu	37	chr17	47797711	47797711	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagtgctccccgcactgcgtGgtcccctaggagtggtgaac	13	14	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:47797711G>C	uc002ipk.2	-	4	619	c.550C>G	c.(550-552)CAC>GAC	p.H184D	FAM117A_uc010wlz.1_5'UTR	NM_030802	NP_110429	Q9C073	F117A_HUMAN	family with sequence similarity 117, member A	184										ovary(1)	1						CGCACTGCGTGGTCCCCTAGG	0.587													0	0	0	0.01441	0	50	99										C	47797711	G	C	47797711	3	2	61	1	0	0	0	0	1	0	0	0	5409	1348	47	4	831	4	FAM117A	17	47797711	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3885671	47797711	33397499	316	17818										
ITGA3	3675	broad.mit.edu	37	chr17	48133990	48133990	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcgccctccatcggcagacaGagcggcagcagcgctacctg	12	16	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:48133990G>A	uc010dbl.2	+	1	651	c.187G>A	c.(187-189)GAG>AAG	p.E63K	ITGA3_uc010dbm.2_Missense_Mutation_p.E63K	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	63	FG-GAP 1.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						TCGGCAGACAGAGCGGCAGCA	0.662													0	0	0	0.00499	0	12	17										A	48133990	G	A	48133990	3	1	61	1	0	0	0	0	1	0	0	0	7877	943	33	1	189	1	ITGA3	17	48133990	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	336279	48133990	33061220	317	17819										
ABCC3	8714	broad.mit.edu	37	chr17	48750918	48750918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tggacaggtgtctgagatggGcccgtacccagccctgctgc	14	13	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:48750918G>A	uc002isl.2	+	19	2578	c.2498G>A	c.(2497-2499)GGC>GAC	p.G833D		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	833	ABC transporter 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TCTGAGATGGGCCCGTACCCA	0.602													0	0	0	0.007291	0	27	120										A	48750918	G	A	48750918	3	1	61	1	0	0	0	0	1	0	0	0	54	1203	42	2	2656	2	ABCC3	17	48750918	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	616928	48750918	32444292	318	17820										
ANKRD40	91369	broad.mit.edu	37	chr17	48784970	48784970	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtcccctaaggccgcggcctCccgcagcctctcctgctgct	10	20	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:48784970C>T	uc002iso.2	-	1	301	c.46G>A	c.(46-48)GAG>AAG	p.E16K		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	16	ANK 1.										0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			GCCGCGGCCTCCCGCAGCCTC	0.493													0	0	0	0.01441	0	65	114										T	48784970	C	T	48784970	3	4	61	1	0	0	0	0	1	0	0	0	669	864	30	1	1080	1	ANKRD40	17	48784970	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	34052	48784970	32410240	319	17821										
GDPD1	284161	broad.mit.edu	37	chr17	57335175	57335175	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtggggtaatgccaattatGaaattgtagaaaagtgctac	11	4	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:57335175G>C	uc002ixk.1	+	6	687	c.550G>C	c.(550-552)GAA>CAA	p.E184Q	GDPD1_uc002ixj.2_Missense_Mutation_p.E184Q	NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	184	Cytoplasmic (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TGCCAATTATGAAATTGTAGA	0.323													0	0	0	0.01441	0	40	54										C	57335175	G	C	57335175	3	2	61	1	0	0	0	0	1	0	0	0	6323	1291	45	1	572	1	GDPD1	17	57335175	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	8550205	57335175	23860035	320	17822										
INTS2	57508	broad.mit.edu	37	chr17	59981823	59981823	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acttatatagttaggtacctGacaagtgtagaaaaggccag	10	6	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:59981823G>A	uc002izn.2	-	9	1405	c.1329C>T	c.(1327-1329)GTC>GTT	p.V443V	INTS2_uc002izm.2_Silent_p.V435V	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	443	Helical; (Potential).				snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TTAGGTACCTGACAAGTGTAG	0.388													0	0	0	0.000602	0	3	5										A	59981823	G	A	59981823	2	1	61	1	0	0	0	0	0	0	0	1	7778	1277	45	1		1	INTS2	17	59981823	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2646648	59981823	21213387	321	17823										
WIPI1	55062	broad.mit.edu	37	chr17	66430741	66430741	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tagagcttttgcccatcaggGacagagaacacccggatgac	11	11	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:66430741G>A	uc010dey.2	-	7	739	c.648C>T	c.(646-648)GTC>GTT	p.V216V	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Silent_p.V134V|WIPI1_uc002jhe.3_RNA	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	216	WD 1.				macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						GCCCATCAGGGACAGAGAACA	0.488													0	0	0	0.009535	0	24	36										A	66430741	G	A	66430741	2	1	61	1	0	0	0	0	0	0	0	1	17367	1161	41	1		1	WIPI1	17	66430741	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6448918	66430741	14764469	322	17824										
ABCA5	23461	broad.mit.edu	37	chr17	67255906	67255906	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttttctcatagtattgtaaGaggaaaatccacagtacaca	6	7	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:67255906G>C	uc002jif.2	-	27	4890	c.3672C>G	c.(3670-3672)CTC>CTG	p.L1224L	ABCA5_uc002jib.2_Silent_p.L190L|ABCA5_uc002jic.2_Silent_p.L447L|ABCA5_uc002jid.2_Silent_p.L141L|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Silent_p.L1224L	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1224	Helical; (Potential).				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					AGTATTGTAAGAGGAAAATCC	0.269													0	0	0	0.00632	0	21	39										C	67255906	G	C	67255906	2	2	61	1	0	0	0	0	0	0	0	1	35	929	33	1		1	ABCA5	17	67255906	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	825165	67255906	13939304	323	17825										
COG1	9382	broad.mit.edu	37	chr17	71197795	71197795	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caacagtgccaagctgcactCagttcttttcatggccagac	8	13	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:71197795C>T	uc002jjg.2	+	7	1865	c.1829C>T	c.(1828-1830)TCA>TTA	p.S610L	COG1_uc002jjh.2_Missense_Mutation_p.S610L|COG1_uc002jjf.1_Missense_Mutation_p.S610L	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	610					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			AAGCTGCACTCAGTTCTTTTC	0.552													0	0	0	0.010504	0	20	27										T	71197795	C	T	71197795	3	4	61	1	0	0	0	0	1	0	0	0	3657	838	29	1	1855	1	COG1	17	71197795	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3941889	71197795	9997415	324	17826										
ITGB4	3691	broad.mit.edu	37	chr17	73749862	73749862	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caaggctgcggctggaagttCgagcccctgctgggggagga	18	10	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:73749862C>G	uc002jpg.2	+	33	4312	c.4125C>G	c.(4123-4125)TTC>TTG	p.F1375L	ITGB4_uc002jph.2_Intron|ITGB4_uc002jpi.3_Intron|ITGB4_uc002jpj.2_Intron|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1375	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGGAAGTTCGAGCCCCTGC	0.657													0	0	0	0.012319	0	14	15										G	73749862	C	G	73749862	3	3	61	1	0	0	0	0	1	0	0	0	7897	883	31	1	4251	1	ITGB4	17	73749862	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2552067	73749862	7445348	325	17827										
GALK1	2584	broad.mit.edu	37	chr17	73759154	73759154	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agtgagatgaactggtccatGatgccacagggcatccctgc	12	11	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:73759154G>A	uc010wsi.1	-	4	615	c.552C>T	c.(550-552)ATC>ATT	p.I184I	GALK1_uc002jpk.2_Silent_p.I184I|GALK1_uc010wsj.1_3'UTR	NM_000154	NP_000145	P51570	GALK1_HUMAN	galactokinase 1	184			I -> M.		galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACTGGTCCATGATGCCACAGG	0.632													0	0	0	0.01441	0	42	64										A	73759154	G	A	73759154	2	1	61	1	0	0	0	0	0	0	0	1	6203	1280	45	1		1	GALK1	17	73759154	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	9292	73759154	7436056	326	17828										
AZI1	22994	broad.mit.edu	37	chr17	79170817	79170817	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gacgtgctcacctcggacccCagctccaggggccccggccc	12	20	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:79170817C>A	uc002jzp.1	-	14	1895	c.1695G>T	c.(1693-1695)CTG>CTT	p.L565L	AZI1_uc002jzm.1_5'UTR|AZI1_uc002jzn.1_Silent_p.L562L|AZI1_uc002jzo.1_Silent_p.L562L|AZI1_uc010wum.1_Silent_p.L565L|AZI1_uc002jzq.2_5'Flank	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	565					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCTCGGACCCCAGCTCCAGGG	0.692													1	0	3.09899e-07	0.004482	3.20966e-07	7	6										A	79170817	C	A	79170817	2	1	61	1	0	0	0	0	0	0	0	1	1240	581	21	4		4	AZI1	17	79170817	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5411663	79170817	2024393	327	17829										
LRRC45	201255	broad.mit.edu	37	chr17	79988565	79988565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gggagaagctgcggctccggGaggcggagatcgcccgcatc	18	12	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:79988565G>A	uc002kde.2	+	17	2137	c.1897G>A	c.(1897-1899)GAG>AAG	p.E633K	RAC3_uc002kdf.2_5'Flank	NM_144999	NP_659436	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	633	Potential.					centrosome				pancreas(1)	1	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GCGGCTCCGGGAGGCGGAGAT	0.697													0	0	0	0.00308	0	7	3										A	79988565	G	A	79988565	3	1	61	1	0	0	0	0	1	0	0	0	9002	1175	41	1	1963	1	LRRC45	17	79988565	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	817748	79988565	1206645	328	17830										
FOXK2	3607	broad.mit.edu	37	chr17	80478010	80478010	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcccggcgccacctcgagatCttcacgcccccgggcggcgg	13	19	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr17:80478010C>T	uc002kfn.2	+	1	417	c.246C>T	c.(244-246)ATC>ATT	p.I82I	FOXK2_uc002kfm.1_Silent_p.I82I|FOXK2_uc010diu.2_Silent_p.I82I	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	82	FHA.|Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			ACCTCGAGATCTTCAcgcccc	0.383													0	0	0	0.012213	0	27	20										T	80478010	C	T	80478010	2	4	61	1	0	0	0	0	0	0	0	1	6015	903	32	1		1	FOXK2	17	80478010	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	489445	80478010	717200	329	17831										
ST8SIA5	29906	broad.mit.edu	37	chr18	44260398	44260398	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgcgtgttgtagaaggcaggCagcagcaccgacgcgttctc	14	12	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr18:44260398C>T	uc002lcj.1	-	7	1306	c.738G>A	c.(736-738)CTG>CTA	p.L246L	ST8SIA5_uc002lci.1_Silent_p.L93L|ST8SIA5_uc010xcy.1_Silent_p.L282L|ST8SIA5_uc010xcz.1_Silent_p.L215L	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	246	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						AGAAGGCAGGCAGCAGCACCG	0.607													0	0	0	0.00308	0	7	15										T	44260398	C	T	44260398	2	4	61	1	0	0	0	0	0	0	0	1	15234	697	25	2		2	ST8SIA5	18	44260398	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		44260398	33816850	330	17832										
ZBTB7C	201501	broad.mit.edu	37	chr18	45556270	45556270	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcttccgcatgtggattttCagcttgtcctgcctgcaatg	10	11	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr18:45556270C>T	uc002lda.2	-	2	1237	c.1221G>A	c.(1219-1221)CTG>CTA	p.L407L	ZBTB7C_uc002ldb.2_Silent_p.L407L|ZBTB7C_uc010dnu.2_Silent_p.L416L|ZBTB7C_uc010dnv.2_Silent_p.L429L|ZBTB7C_uc010dnw.2_Silent_p.L407L	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	407	C2H2-type 2.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TGTGGATTTTCAGCTTGTCCT	0.577													0	0	0	0.00245	0	14	40										T	45556270	C	T	45556270	2	4	61	1	0	0	0	0	0	0	0	1	17552	813	29	1		1	ZBTB7C	18	45556270	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1295872	45556270	32520978	331	17833										
KIAA1468	57614	broad.mit.edu	37	chr18	59954630	59954630	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gccttggtgaacaacttacaGattgtggattctaaaagact	9	7	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr18:59954630G>A	uc002lil.2	+	26	3515	c.3300G>A	c.(3298-3300)CAG>CAA	p.Q1100Q	KIAA1468_uc010xel.1_Silent_p.Q1100Q|KIAA1468_uc002lim.2_Silent_p.Q778Q	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	1100							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				ACAACTTACAGATTGTGGATT	0.348													0	0	0	0.011902	0	39	24										A	59954630	G	A	59954630	2	1	61	1	0	0	0	0	0	0	0	1	8236	933	33	1		1	KIAA1468	18	59954630	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	14398360	59954630	18122618	332	17834										
NETO1	81832	broad.mit.edu	37	chr18	70417577	70417577	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcatttggaagatgacctccGcagtttatggtaattttcaa	9	7	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr18:70417577G>A	uc002lkw.2	-	9	1545	c.1261C>T	c.(1261-1263)CGG>TGG	p.R421W	NETO1_uc002lkx.1_Missense_Mutation_p.R420W|NETO1_uc002lky.1_Missense_Mutation_p.R421W	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	421	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GATGACCTCCGCAGTTTATGG	0.458													0	0	0	0.008871	0	16	9										A	70417577	G	A	70417577	3	1	61	1	0	0	0	0	1	0	0	0	10339	1086	38	2	348	2	NETO1	18	70417577	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	10462947	70417577	7659671	333	17835										
SALL3	27164	broad.mit.edu	37	chr18	76752223	76752223	+	Frame_Shift_Del	DEL	C	C	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggagctgcaccaagctcccgCccgtgctgatcgtgcacgag							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr18:76752223delC	uc002lmt.2	+	2	232	c.232delC	c.(232-234)CCCfs	p.P78fs	SALL3_uc010dra.2_5'Flank	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	78					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAAGCTCCCGCCCGTGCTGAT	0.716																		26	18	---	---								-	76752223	C	-	76752223	7	5	61	1	0	1	0	1	0	0	0	0	13812	739	26	0	238	0	SALL3	18	76752223	Frame_Shift_Del	DEL	C	TCGA-DK-A3IS-01A-21D-A21A-08	6334646	76752223	1325025	334	17836										
DAZAP1	26528	broad.mit.edu	37	chr19	1434776	1434776	+	Frame_Shift_Del	DEL	C	C	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agtggcttcggacagggcttCtcagaccccagccagcagcc							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:1434776delC	uc002lsn.2	+	12	1278	c.1089delC	c.(1087-1089)TTCfs	p.F363fs	DAZAP1_uc002lsm.2_3'UTR|DAZAP1_uc002lso.2_Frame_Shift_Del_p.F362fs|DAZAP1_uc002lsl.1_Frame_Shift_Del_p.F362fs	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	363	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACAGGGCTTCTCAGACCCCA	0.592																		48	67	---	---								-	1434776	C	-	1434776	7	5	61	1	0	1	0	1	0	0	0	0	4244	912	32	0	1228	0	DAZAP1	19	1434776	Frame_Shift_Del	DEL	C	TCGA-DK-A3IS-01A-21D-A21A-08		1434776	57694207	335	17837										
CELF5	60680	broad.mit.edu	37	chr19	3275921	3275921	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaggacgtgctgcggctgttCcagcccttcggggtcattga	15	11	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:3275921C>G	uc002lxm.2	+	4	499	c.462C>G	c.(460-462)TTC>TTG	p.F154L	CELF5_uc002lxl.1_Missense_Mutation_p.F154L|CELF5_uc010dtj.1_Missense_Mutation_p.F154L|CELF5_uc010xhg.1_Missense_Mutation_p.F40L|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	154	RRM 2.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						TGCGGCTGTTCCAGCCCTTCG	0.552													0	0	0	0.01441	0	37	27										G	3275921	C	G	3275921	3	3	61	1	0	0	0	0	1	0	0	0	3219	854	30	1	476	1	CELF5	19	3275921	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1841145	3275921	55853062	336	17838										
ZFR2	23217	broad.mit.edu	37	chr19	3816707	3816707	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagctgctgggcgatcctccGcagcaggctgtgcgtgggct	16	13	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:3816707G>A	uc002lyw.2	-	13	2080	c.2068C>T	c.(2068-2070)CGG>TGG	p.R690W		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	690						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		GCGATCCTCCGCAGCAGGCTG	0.687													0	0	0	0.009096	0	3	35										A	3816707	G	A	3816707	3	1	61	1	0	0	0	0	1	0	0	0	17657	1086	38	2	779	2	ZFR2	19	3816707	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	540786	3816707	55312276	337	17839										
ITGB1BP3	27231	broad.mit.edu	37	chr19	3938612	3938612	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttccccagtgctggagtctCtggacatggaggccatgctg	13	11	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:3938612C>T	uc002lyz.3	+	5	468	c.178C>T	c.(178-180)CTG>TTG	p.L60L	ITGB1BP3_uc010xia.1_Silent_p.L65L	NM_170678	NP_733778	Q9NPI5	NRK2_HUMAN	integrin beta 1 binding protein 3	60					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|protein binding|ribosylnicotinamide kinase activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGAGTCTCTGGACATGGA	0.682													0	0	0	0.006122	0	15	22										T	3938612	C	T	3938612	2	4	61	1	0	0	0	0	0	0	0	1	7893	912	32	1		1	ITGB1BP3	19	3938612	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	121905	3938612	55190371	338	17840										
LRG1	116844	broad.mit.edu	37	chr19	4538453	4538453	+	Frame_Shift_Del	DEL	G	G	-													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtgaagttggccagcagcccGgggggcagtttccggaggcg							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:4538453delG	uc002mau.2	-	2	554	c.543delC	c.(541-543)CCCfs	p.P181fs	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	181	LRR 4.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGCAGCCCGGGGGGCAGTT	0.622																		7	264	---	---								-	4538453	G	-	4538453	7	5	61	1	0	1	0	1	0	0	0	0	8942	1103	39	0	504	0	LRG1	19	4538453	Frame_Shift_Del	DEL	G	TCGA-DK-A3IS-01A-21D-A21A-08	599841	4538453	54590530	339	17841										
SNAPC2	6618	broad.mit.edu	37	chr19	7986331	7986331	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgggtcttcctccagcagctCaagggccgcgtagcccggga	14	15	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:7986331C>G	uc002miw.1	+	2	230	c.207C>G	c.(205-207)CTC>CTG	p.L69L	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	69					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						TCCAGCAGCTCAAGGGCCGCG	0.622													0	0	0	0.003755	0	27	38										G	7986331	C	G	7986331	2	3	61	1	0	0	0	0	0	0	0	1	14835	813	29	1		1	SNAPC2	19	7986331	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3447878	7986331	51142652	340	17842										
ADAMTS10	81794	broad.mit.edu	37	chr19	8665898	8665898	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtcagccaccaccagggtctCcacgtagcgctctcggctga	11	16	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:8665898C>G	uc002mkj.1	-	6	998	c.724G>C	c.(724-726)GAG>CAG	p.E242Q	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	242	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						ACCAGGGTCTCCACGTAGCGC	0.622													0	0	0	0.01441	0	45	60										G	8665898	C	G	8665898	3	3	61	1	0	0	0	0	1	0	0	0	256	864	30	1	2671	1	ADAMTS10	19	8665898	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	679567	8665898	50463085	341	17843										
MUC16	94025	broad.mit.edu	37	chr19	9082528	9082528	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cttctgcaatggtctggcttGaggttaactcaggaggctcc	12	10	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9082528G>T	uc002mkp.2	-	1	9491	c.9287C>A	c.(9286-9288)TCA>TAA	p.S3096*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3097	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTCTGGCTTGAGGTTAACTC	0.478													1	0	4.03479e-65	0.01441	4.44007e-65	82	73										T	9082528	G	T	9082528	4	4	61	1	0	0	0	0	0	1	0	0	9973	1294	45	3	34572	3	MUC16	19	9082528	Nonsense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	416630	9082528	50046455	342	17844			4	76		3	3	529	G		2.548802e-05
MUC16	94025	broad.mit.edu	37	chr19	9082810	9082810	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagaggtcgatgtcatagctGatgatgccttgcttgggtct	14	7	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9082810G>A	uc002mkp.2	-	1	9209	c.9005C>T	c.(9004-9006)TCA>TTA	p.S3002L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3003	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTCATAGCTGATGATGCCTT	0.507													0	0	0	0.01441	0	50	55										A	9082810	G	A	9082810	3	1	61	1	0	0	0	0	1	0	0	0	9973	1294	45	1	34854	1	MUC16	19	9082810	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	282	9082810	50046173	343	17845			4	76		3	3	529	G		2.548802e-05
MUC16	94025	broad.mit.edu	37	chr19	9083056	9083056	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aagatgctgtgcttgcatctGagtctggaatggtgttcagg	14	6	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9083056G>A	uc002mkp.2	-	1	8963	c.8759C>T	c.(8758-8760)TCA>TTA	p.S2920L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2921	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTTGCATCTGAGTCTGGAAT	0.463													0	0	0	0.00333	0	22	17										A	9083056	G	A	9083056	3	1	61	1	0	0	0	0	1	0	0	0	9973	1294	45	1	35100	1	MUC16	19	9083056	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	246	9083056	50045927	344	17846			4	76		3	3	529	G		2.548802e-05
ZNF559	84527	broad.mit.edu	37	chr19	9453579	9453579	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcaggccttacagtacacatGagaactcacactggtgaacg	9	11	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9453579G>T	uc002mlg.2	+	7	2099	c.1452G>T	c.(1450-1452)ATG>ATT	p.M484I	ZNF559_uc002mlf.2_Missense_Mutation_p.M253I|ZNF559_uc010dwl.1_Missense_Mutation_p.M253I|ZNF559_uc010xkn.1_Missense_Mutation_p.M476I|ZNF559_uc010dwm.1_3'UTR|ZNF559_uc002mle.3_Missense_Mutation_p.M548I|ZNF559_uc010dwk.1_Missense_Mutation_p.M253I|ZNF559_uc002mld.2_3'UTR|ZNF559_uc010dwo.1_Intron|ZNF177_uc002mli.2_Intron|ZNF177_uc002mlj.2_Intron	NM_032497	NP_115886	Q9BR84	ZN559_HUMAN	zinc finger protein 559	484	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGTACACATGAGAACTCACA	0.433													1	0	4.3181e-19	0.013726	4.60784e-19	28	29										T	9453579	G	T	9453579	3	4	61	1	0	0	0	0	1	0	0	0	17987	1290	45	3	1466	3	ZNF559	19	9453579	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	370523	9453579	49675404	345	17847										
ZNF177	7730	broad.mit.edu	37	chr19	9492184	9492184	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acacacgctctcacactggaGagaagccttatgagtgtaac	9	11	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9492184G>C	uc002mli.2	+	12	1360	c.697G>C	c.(697-699)GAG>CAG	p.E233Q	ZNF177_uc002mlj.2_Missense_Mutation_p.E183Q|ZNF177_uc002mlk.2_Missense_Mutation_p.E233Q	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	233					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCACACTGGAGAGAAGCCTTA	0.468													0	0	0	0.01441	0	55	101										C	9492184	G	C	9492184	3	2	61	1	0	0	0	0	1	0	0	0	17743	943	33	1	1195	1	ZNF177	19	9492184	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	38605	9492184	49636799	346	17848										
ZNF846	162993	broad.mit.edu	37	chr19	9868234	9868234	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttcccacatttcttacattCatatggttttgctccagtgt	5	10	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9868234C>A	uc002mmb.1	-	6	2050	c.1519G>T	c.(1519-1521)GAA>TAA	p.E507*	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Nonsense_Mutation_p.E378*	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	507	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCTTACATTCATATGGTTTT	0.393													1	0	3.39706e-21	0.01441	3.65666e-21	42	81										A	9868234	C	A	9868234	4	1	61	1	0	0	0	0	0	1	0	0	18189	835	29	3	86	3	ZNF846	19	9868234	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	376050	9868234	49260749	347	17849										
ZNF846	162993	broad.mit.edu	37	chr19	9868950	9868950	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttctgatgtgtaatttaagtCctgtggattgagtgaaagct	11	4	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9868950C>A	uc002mmb.1	-	6	1334	c.803G>T	c.(802-804)GGA>GTA	p.G268V	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Missense_Mutation_p.G139V|ZNF846_uc002mmc.1_Missense_Mutation_p.G139V	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	268	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAATTTAAGTCCTGTGGATTG	0.388													1	0	9.65021e-13	0.010818	1.0144e-12	28	40										A	9868950	C	A	9868950	3	1	61	1	0	0	0	0	1	0	0	0	18189	855	30	3	802	3	ZNF846	19	9868950	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	716	9868950	49260033	348	17850										
ZNF846	162993	broad.mit.edu	37	chr19	9869338	9869338	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attatcctcagaagttttctCtccaatgtgagttatcatgt	6	8	3	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:9869338C>T	uc002mmb.1	-	6	946	c.415G>A	c.(415-417)GAG>AAG	p.E139K	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Missense_Mutation_p.E10K|ZNF846_uc002mmc.1_Missense_Mutation_p.E10K	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAAGTTTTCTCTCCAATGTGA	0.378													0	0	0	0.009535	0	27	47										T	9869338	C	T	9869338	3	4	61	1	0	0	0	0	1	0	0	0	18189	922	32	1	1190	1	ZNF846	19	9869338	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	388	9869338	49259645	349	17851										
DNMT1	1786	broad.mit.edu	37	chr19	10266565	10266565	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagggccttttcacctccatCaaagccagtgatccaccatt	7	14	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:10266565C>T	uc002mng.2	-	18	1588	c.1408G>A	c.(1408-1410)GAT>AAT	p.D470N	DNMT1_uc010xlc.1_Missense_Mutation_p.D486N|DNMT1_uc002mnh.2_Missense_Mutation_p.D365N|DNMT1_uc010xld.1_Missense_Mutation_p.D470N	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	470	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TCACCTCCATCAAAGCCAGTG	0.502													0	0	0	0.001855	0	10	16										T	10266565	C	T	10266565	3	4	61	1	0	0	0	0	1	0	0	0	4675	826	29	1	3534	1	DNMT1	19	10266565	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	397227	10266565	48862418	350	17852										
ATG4D	84971	broad.mit.edu	37	chr19	10663612	10663612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	accccatgttcaccctggccGagggccatgctcaggaccac	10	17	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:10663612G>A	uc002mov.2	+	10	1414	c.1294G>A	c.(1294-1296)GAG>AAG	p.E432K	ATG4D_uc010xlh.1_Missense_Mutation_p.E369K|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Missense_Mutation_p.E99K	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	432					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CACCCTGGCCGAGGGCCATGC	0.662													0	0	0	0.01441	0	79	90										A	10663612	G	A	10663612	3	1	61	1	0	0	0	0	1	0	0	0	1099	1059	37	1	1332	1	ATG4D	19	10663612	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	397047	10663612	48465371	351	17853										
SMARCA4	6597	broad.mit.edu	37	chr19	11123777	11123777	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aatgggcccttcctcatcatCgtgcctctctcgtgagtacc	8	15	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:11123777C>T	uc002mqf.3	+	16	2711	c.2427C>T	c.(2425-2427)ATC>ATT	p.I809I	SMARCA4_uc010dxp.2_Silent_p.I809I|SMARCA4_uc010dxo.2_Silent_p.I809I|SMARCA4_uc002mqg.1_Silent_p.I809I|SMARCA4_uc010dxq.2_Silent_p.I809I|SMARCA4_uc010dxr.2_Silent_p.I809I|SMARCA4_uc002mqj.3_Silent_p.I809I|SMARCA4_uc010dxs.2_Silent_p.I809I|SMARCA4_uc010dxt.1_Silent_p.I29I	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	809	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TCCTCATCATCGTGCCTCTCT	0.483			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.003954	0	18	26										T	11123777	C	T	11123777	2	4	61	1	0	0	0	0	0	0	0	1	14770	874	31	1		1	SMARCA4	19	11123777	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	460165	11123777	48005206	352	17854										
ACP5	54	broad.mit.edu	37	chr19	11687649	11687649	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcggtcagagaatacgtcctCaaaggtctcctgtagcaaac	10	11	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:11687649C>G	uc002msg.3	-	3	417	c.271G>C	c.(271-273)GAG>CAG	p.E91Q	ACP5_uc002msh.3_Missense_Mutation_p.E91Q|ACP5_uc002msi.3_Missense_Mutation_p.E91Q|ACP5_uc002msj.3_Missense_Mutation_p.E91Q|ACP5_uc010dye.1_3'UTR	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	91					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						AATACGTCCTCAAAGGTCTCC	0.552													0	0	0	0.01441	0	54	48										G	11687649	C	G	11687649	3	3	61	1	0	0	0	0	1	0	0	0	164	835	29	1	718	1	ACP5	19	11687649	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	563872	11687649	47441334	353	17855										
PRDX2	7001	broad.mit.edu	37	chr19	12911854	12911854	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcacacaaaagtgaagtccaGagggtagaaaaagaggacca	12	7	0	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:12911854G>C	uc002mvd.2	-	3	283	c.133C>G	c.(133-135)CTG>GTG	p.L45V	PRDX2_uc002mve.1_Missense_Mutation_p.L45V	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	45	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						GTGAAGTCCAGAGGGTAGAAA	0.602													0	0	0	0.014323	0	20	25										C	12911854	G	C	12911854	3	2	61	1	0	0	0	0	1	0	0	0	12465	933	33	1	651	1	PRDX2	19	12911854	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1224205	12911854	46217129	354	17856										
IER2	9592	broad.mit.edu	37	chr19	13264409	13264409	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcggggacgctggactggtcCcgagcaagaaagcccgtctg	16	12	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:13264409C>T	uc002mwr.2	+	2	737	c.409C>T	c.(409-411)CCG>TCG	p.P137S		NM_004907	NP_004898	Q9BTL4	IER2_HUMAN	immediate early response 2	137										kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			TGGACTGGTCCCGAGCAAGAA	0.687											OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	2										T	13264409	C	T	13264409	3	4	61	1	0	0	0	0	1	0	0	0	7505	623	22	2	411	2	IER2	19	13264409	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	352555	13264409	45864574	355	17857										
CYP4F12	66002	broad.mit.edu	37	chr19	15806821	15806821	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttacatcccccagctcccttCatctcccgatgctgcaccca	4	20	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:15806821C>T	uc002nbl.2	+	10	1252	c.1191C>T	c.(1189-1191)TTC>TTT	p.F397F		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CAGCTCCCTTCATCTCCCGAT	0.617													0	0	0	0.01441	0	48	64										T	15806821	C	T	15806821	2	4	61	1	0	0	0	0	0	0	0	1	4187	825	29	1		1	CYP4F12	19	15806821	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2542412	15806821	43322162	356	17858										
CYP4F12	66002	broad.mit.edu	37	chr19	15807291	15807291	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	acagcaaggggaggtcacctCtggcttttattcctttctcc	9	12	3	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:15807291C>G	uc002nbl.2	+	12	1427	c.1366C>G	c.(1366-1368)CTG>GTG	p.L456V		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GAGGTCACCTCTGGCTTTTAT	0.557													0	0	0	0.01441	0	63	99										G	15807291	C	G	15807291	3	3	61	1	0	0	0	0	1	0	0	0	4187	912	32	1	1408	1	CYP4F12	19	15807291	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	470	15807291	43321692	357	17859										
CHERP	10523	broad.mit.edu	37	chr19	16631645	16631645	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctgcgcttttacctgttcctCttctcctggcctttcctccg	6	17	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:16631645C>G	uc002nei.1	-	13	2267	c.2193G>C	c.(2191-2193)AAG>AAC	p.K731N	MED26_uc002nee.2_Intron|C19orf44_uc002neh.1_3'UTR|C19orf44_uc010eai.1_RNA|CHERP_uc010xpg.1_Missense_Mutation_p.K270N	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	731	Arg-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						ACCTGTTCCTCTTCTCCTGGC	0.592													0	0	0	0.010771	0	36	47										G	16631645	C	G	16631645	3	3	61	1	0	0	0	0	1	0	0	0	3336	912	32	1	577	1	CHERP	19	16631645	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	824354	16631645	42497338	358	17860										
USHBP1	83878	broad.mit.edu	37	chr19	17362467	17362467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ccccttctgagccacctgttCcagctccctgcgcagagact	8	18	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:17362467C>T	uc002nfs.1	-	12	1959	c.1846G>A	c.(1846-1848)GAA>AAA	p.E616K	USHBP1_uc002nfr.1_Missense_Mutation_p.E242K|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Missense_Mutation_p.E552K	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	616	Potential.						PDZ domain binding			ovary(1)	1						GCCACCTGTTCCAGCTCCCTG	0.607													0	0	0	0.01441	0	46	82										T	17362467	C	T	17362467	3	4	61	1	0	0	0	0	1	0	0	0	17034	864	30	1	273	1	USHBP1	19	17362467	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	730822	17362467	41766516	359	17861										
MAST3	23031	broad.mit.edu	37	chr19	18255941	18255941	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcagcctgcggccccccatcGttatccacagctctggcaag	10	17	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:18255941G>T	uc002nhz.3	+	23	2854	c.2854G>T	c.(2854-2856)GTT>TTT	p.V952F		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	952	PDZ.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.S952L(1)		large_intestine(2)|ovary(2)|stomach(1)	5						GCCCCCCATCGTTATCCACAG	0.652													1	0	2.76863e-45	0.01441	3.03319e-45	74	105										T	18255941	G	T	18255941	3	4	61	1	0	0	0	0	1	0	0	0	9326	1145	40	4	2944	4	MAST3	19	18255941	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	893474	18255941	40873042	360	17862										
ZNF43	7594	broad.mit.edu	37	chr19	21990730	21990730	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttttcacatttgtagggtttCtctccagtatgaataatctt	6	7	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:21990730C>T	uc002nqj.2	-	4	2239	c.2109G>A	c.(2107-2109)GAG>GAA	p.E703E	ZNF43_uc010ecv.2_Silent_p.E697E|ZNF43_uc002nql.2_Silent_p.E697E|ZNF43_uc002nqm.2_Silent_p.E697E|ZNF43_uc002nqk.2_Silent_p.E633E	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	703					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TGTAGGGTTTCTCTCCAGTAT	0.363													0	0	0	0.014323	0	20	24										T	21990730	C	T	21990730	2	4	61	1	0	0	0	0	0	0	0	1	17900	912	32	1		1	ZNF43	19	21990730	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3734789	21990730	37138253	361	17863										
U2AF1L4	199746	broad.mit.edu	37	chr19	36233667	36233667	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggaacaccgatggttcctctCtcggggatggtggccagtat	14	10	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:36233667C>G	uc002obg.2	-	8	822	c.513G>C	c.(511-513)GAG>GAC	p.E171D	TMEM149_uc002obb.2_5'Flank|TMEM149_uc002obc.2_5'Flank|TMEM149_uc002obd.3_5'Flank|TMEM149_uc010xsy.1_5'Flank|TMEM149_uc010eej.2_Intron|U2AF1L4_uc002obh.1_3'UTR|U2AF1L4_uc002obe.2_Missense_Mutation_p.E167Q|U2AF1L4_uc002obf.2_Missense_Mutation_p.E147D|PSENEN_uc002obi.1_5'Flank|PSENEN_uc002obj.1_5'Flank|PSENEN_uc002obk.1_5'Flank			Q8WU68	U2AF4_HUMAN	Homo sapiens cDNA FLJ35525 fis, clone SPLEN2001650.	Error:Variant_position_missing_in_Q8WU68_after_alignment					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGTTCCTCTCTCGGGGATGG	0.602													0	0	0	0.01441	0	46	74										G	36233667	C	G	36233667	3	3	61	1	0	0	0	0	1	0	0	0	16819	922	32	1	171	1	U2AF1L4	19	36233667	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	14242937	36233667	22895316	362	17864										
CEACAM8	1088	broad.mit.edu	37	chr19	43097723	43097723	+	Missense_Mutation	SNP	C	C	T													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaactggccagttacttcttCactcataagatttagcttta							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:43097723C>T	uc002oud.2	-	2	496	c.394G>A	c.(394-396)GAA>AAA	p.E132K	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	132	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				GTTACTTCTTCACTCATAAGA	0.483													0	0	0	0.00623	0	39	80										T	43097723	C	T	43097723	3	4	61	1	0	0	0	0	1	0	0	0	3198	835	29	1	671	1	CEACAM8	19	43097723	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	6864056	43097723	16031260	363	17865	86	2								
CEACAM8	1088	broad.mit.edu	37	chr19	43097727	43097727	+	Missense_Mutation	SNP	C	C	A													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tggccagttacttcttcactCataagatttagctttatgac							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:43097727C>A	uc002oud.2	-	2	492	c.390G>T	c.(388-390)ATG>ATT	p.M130I	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	130	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				CTTCTTCACTCATAAGATTTA	0.473													1	0	1.22674e-20	0.00874	1.31475e-20	43	85										A	43097727	C	A	43097727	3	1	61	1	0	0	0	0	1	0	0	0	3198	826	29	3	675	3	CEACAM8	19	43097727	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	4	43097727	16031256	364	17866	86	2								
ZNF224	7767	broad.mit.edu	37	chr19	44612276	44612276	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tagaaaagccatacaaatgtGaggactgtgggaagggctac	13	6	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:44612276G>A	uc002oyh.1	+	6	2265	c.1963G>A	c.(1963-1965)GAG>AAG	p.E655K	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	655	C2H2-type 17.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				ATACAAATGTGAGGACTGTGG	0.433													0	0	0	0.013114	0	36	59										A	44612276	G	A	44612276	3	1	61	1	0	0	0	0	1	0	0	0	17775	1291	45	1	1977	1	ZNF224	19	44612276	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1514549	44612276	14516707	365	17867										
PVRL2	5819	broad.mit.edu	37	chr19	45375333	45375333	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcgggccgagcagatggtgtCacggtcacctgcaaagtgga	15	10	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:45375333C>T	uc002ozw.1	+	3	1092	c.702C>T	c.(700-702)GTC>GTT	p.V234V	PVRL2_uc002ozv.2_Silent_p.V234V	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	234	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CAGATGGTGTCACGGTCACCT	0.607													0	0	0	0.01441	0	43	49										T	45375333	C	T	45375333	2	4	61	1	0	0	0	0	0	0	0	1	12840	813	29	1		1	PVRL2	19	45375333	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	763057	45375333	13753650	366	17868										
PVRL2	5819	broad.mit.edu	37	chr19	45375398	45375398	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cctgatacctgtgaccctctCtgtacgctgtgagtgtatcg	10	12	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:45375398C>G	uc002ozw.1	+	3	1157	c.767C>G	c.(766-768)TCT>TGT	p.S256C	PVRL2_uc002ozv.2_Missense_Mutation_p.S256C	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	256	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		GTGACCCTCTCTGTACGCTGT	0.547													0	0	0	0.01441	0	65	67										G	45375398	C	G	45375398	3	3	61	1	0	0	0	0	1	0	0	0	12840	913	32	1	777	1	PVRL2	19	45375398	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	65	45375398	13753585	367	17869										
PPP1R13L	10848	broad.mit.edu	37	chr19	45899848	45899848	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgcgctgccgccggagcctaGcagggagctcccgaaggcgg	17	14	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:45899848G>A	uc002pbn.2	-	4	744	c.667C>T	c.(667-669)CTA>TTA	p.L223L	PPP1R13L_uc002pbo.2_Silent_p.L223L|PPP1R13L_uc002pbp.2_Silent_p.L223L	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	223	Pro-rich.			L -> I (in Ref. 3; AAW51146).	apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CCGGAGCCTAGCAGGGAGCTC	0.756													0	0	0	0.00245	0	13	9										A	45899848	G	A	45899848	2	1	61	1	0	0	0	0	0	0	0	1	12358	962	34	2		2	PPP1R13L	19	45899848	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	524450	45899848	13229135	368	17870										
SYMPK	8189	broad.mit.edu	37	chr19	46328437	46328437	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caggggcctcaccggctgctCaatgaccctcagcaccgtcc	10	18	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:46328437C>T	uc002pdn.2	-	18	2727	c.2482G>A	c.(2482-2484)GAG>AAG	p.E828K	SYMPK_uc002pdo.1_Missense_Mutation_p.E828K|SYMPK_uc002pdp.1_Missense_Mutation_p.E828K	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	828					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		ACCGGCTGCTCAATGACCCTC	0.652													0	0	0	0.01441	0	56	68										T	46328437	C	T	46328437	3	4	61	1	0	0	0	0	1	0	0	0	15436	835	29	1	1382	1	SYMPK	19	46328437	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	428589	46328437	12800546	369	17871										
ZC3H4	23211	broad.mit.edu	37	chr19	47597706	47597706	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctttctcccgctctttcttCcgtttccgcttcagtctcct	4	17	6	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:47597706C>T	uc002pga.3	-	3	359	c.321G>A	c.(319-321)CGG>CGA	p.R107R	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	107	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GCTCTTTCTTCCGTTTCCGCT	0.537													0	0	0	0.01441	0	124	212										T	47597706	C	T	47597706	2	4	61	1	0	0	0	0	0	0	0	1	17567	842	30	1		1	ZC3H4	19	47597706	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1269269	47597706	11531277	370	17872										
HRC	3270	broad.mit.edu	37	chr19	49657096	49657096	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atccttgaccactgtgtgtcCtggggggtgatggctcatct	13	10	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:49657096C>G	uc002pmv.2	-	1	1586	c.1399G>C	c.(1399-1401)GGA>CGA	p.G467R		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	467					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		ACTGTGTGTCCTGGGGGGTGA	0.547													0	0	0	0.00874	0	33	58										G	49657096	C	G	49657096	3	3	61	1	0	0	0	0	1	0	0	0	7352	690	24	4	724	4	HRC	19	49657096	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	2059390	49657096	9471887	371	17873										
TEAD2	8463	broad.mit.edu	37	chr19	49852054	49852054	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gagcctgccaggctgggggcGatggggtaggtgggggcagg	24	7	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:49852054G>C	uc002pnj.2	-	8	732	c.641C>G	c.(640-642)TCG>TGG	p.S214W	TEAD2_uc002png.2_Missense_Mutation_p.S217W|TEAD2_uc002pnh.2_Missense_Mutation_p.S218W|TEAD2_uc002pni.2_Missense_Mutation_p.S217W|TEAD2_uc010yao.1_Missense_Mutation_p.S86W|TEAD2_uc010emw.2_Missense_Mutation_p.S217W	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	214	Transcriptional activation (Potential).|Pro-rich.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		GGCTGGGGGCGATGGGGTAGG	0.572													0	0	0	0.010729	0	11	7										C	49852054	G	C	49852054	3	2	61	1	0	0	0	0	1	0	0	0	15736	1059	37	1	722	1	TEAD2	19	49852054	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	194958	49852054	9276929	372	17874										
SPIB	6689	broad.mit.edu	37	chr19	50926888	50926888	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gttcccccggcatatgccccGtaccccagccctgtgctatc	8	19	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:50926888G>A	uc002psd.2	+	5	391	c.366G>A	c.(364-366)CCG>CCA	p.P122P	SPIB_uc002pse.2_Silent_p.P122P|SPIB_uc010ycc.1_Silent_p.P31P	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	122					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CATATGCCCCGTACCCCAGCC	0.647													0	0	0	0.009535	0	22	29										A	50926888	G	A	50926888	2	1	61	1	0	0	0	0	0	0	0	1	15049	1132	40	2		2	SPIB	19	50926888	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1074834	50926888	8202095	373	17875										
KLK8	11202	broad.mit.edu	37	chr19	51503318	51503318	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gccaggctgggtgcaatgatCtgccaggctgatgggcttca	15	10	2	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:51503318C>T	uc002pur.1	-	4	606	c.427G>A	c.(427-429)GAT>AAT	p.D143N	KLK8_uc002puq.1_Missense_Mutation_p.D188N|KLK8_uc002pus.1_Intron|KLK8_uc002put.1_Intron|KLK8_uc002puu.1_Missense_Mutation_p.D143N|KLK9_uc002puv.1_Intron	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	143	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GTGCAATGATCTGCCAGGCTG	0.587													0	0	0	0.004007	0	16	23										T	51503318	C	T	51503318	3	4	61	1	0	0	0	0	1	0	0	0	8410	913	32	1	367	1	KLK8	19	51503318	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	576430	51503318	7625665	374	17876										
ZNF600	162966	broad.mit.edu	37	chr19	53269283	53269283	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gtaagatttctctccagtatGaagtctacgatggtgaacaa	9	7	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:53269283G>A	uc002qab.3	-	3	2012	c.1726C>T	c.(1726-1728)CAT>TAT	p.H576Y		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	576	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TCTCCAGTATGAAGTCTACGA	0.438													0	0	0	0.01441	0	113	117										A	53269283	G	A	53269283	3	1	61	1	0	0	0	0	1	0	0	0	18027	1290	45	1	446	1	ZNF600	19	53269283	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1765965	53269283	5859700	375	17877										
ZNF320	162967	broad.mit.edu	37	chr19	53384365	53384365	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcaagatgtgatttgcgactGaaaactttgtcgcattcttc	8	8	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:53384365G>A	uc002qag.2	-	4	1205	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.F284F|ZNF320_uc002qai.2_Silent_p.F338F	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	338	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ATTTGCGACTGAAAACTTTGT	0.423													0	0	0	0.005524	0	36	36										A	53384365	G	A	53384365	2	1	61	1	0	0	0	0	0	0	0	1	17836	1281	45	1		1	ZNF320	19	53384365	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	115082	53384365	5744618	376	17878										
NLRP12	91662	broad.mit.edu	37	chr19	54313767	54313767	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttgaagacttggcccgcctgCtctgcattgtggaaatactt	10	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:54313767C>T	uc002qch.3	-	3	1366	c.1146G>A	c.(1144-1146)GAG>GAA	p.E382E	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.E382E|NLRP12_uc002qcj.3_Silent_p.E382E|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.E382E	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	382	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GGCCCGCCTGCTCTGCATTGT	0.562													0	0	0	0.01441	0	104	184										T	54313767	C	T	54313767	2	4	61	1	0	0	0	0	0	0	0	1	10474	796	28	2		2	NLRP12	19	54313767	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	929402	54313767	4815216	377	17879										
KIR3DP1	768329	broad.mit.edu	37	chr19	55267599	55267599	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcagggggcctggccacatgAgggtgagtccttctccaaac	14	12	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:55267599A>C	uc010yfi.1	+	2	69	c.68A>C	c.(67-69)GAG>GCG	p.E23A	KIR2DS4_uc010yfj.1_Intron|KIR2DL3_uc010erw.1_Intron|KIR2DL1_uc002qgz.1_Intron|KIR2DL3_uc002qha.1_Intron	NM_001015070	NP_001015070			killer-cell Ig-like receptor												0				GBM - Glioblastoma multiforme(193;0.0192)		TGGCCACATGAGGGTGAGTCC	0.532													0	0	0	0.00278	0	15	129										C	55267599	A	C	55267599	3	2	61	1	0	0	0	0	1	0	0	0	8323	304	11	5	74	5	KIR3DP1	19	55267599	Missense_Mutation	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	953832	55267599	3861384	378	17880										
NLRP2	55655	broad.mit.edu	37	chr19	55494122	55494122	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atcctggcggaggagccgatCtacataagggtggagggctt	16	8	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:55494122C>G	uc002qij.2	+	6	1142	c.1056C>G	c.(1054-1056)ATC>ATG	p.I352M	NLRP2_uc010yfp.1_Missense_Mutation_p.I329M|NLRP2_uc010esn.2_Missense_Mutation_p.I328M|NLRP2_uc010eso.2_Missense_Mutation_p.I349M|NLRP2_uc010esp.2_Missense_Mutation_p.I330M	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	352	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGGAGCCGATCTACATAAGGG	0.607													0	0	0	0.010729	0	10	13										G	55494122	C	G	55494122	3	3	61	1	0	0	0	0	1	0	0	0	10477	903	32	1	1074	1	NLRP2	19	55494122	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	226523	55494122	3634861	379	17881										
C19orf51	352909	broad.mit.edu	37	chr19	55673126	55673126	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agaggcggctcatggggaacGcctggggccctttctcgccg	16	13	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr19:55673126G>A	uc002qji.1	-	6	582	c.548C>T	c.(547-549)GCG>GTG	p.A183V	C19orf51_uc002qjh.1_5'UTR|C19orf51_uc002qjj.1_Missense_Mutation_p.A230V|C19orf51_uc002qjk.1_Missense_Mutation_p.A129V|C19orf51_uc002qjl.1_Missense_Mutation_p.A251V			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	183											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CATGGGGAACGCCTGGGGCCC	0.711													0	0	0	0.000602	0	4	1										A	55673126	G	A	55673126	3	1	61	1	0	0	0	0	1	0	0	0	1933	1087	38	2	1105	2	C19orf51	19	55673126	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	179004	55673126	3455857	380	17882										
NSFL1C	55968	broad.mit.edu	37	chr20	1433191	1433191	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttgaaggctcctttgggcttCacaaagtcctcgtcccgatg	10	12	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:1433191C>A	uc002wfc.2	-	7	1680	c.732G>T	c.(730-732)GTG>GTT	p.V244V	NSFL1C_uc002wfd.2_Silent_p.V133V|NSFL1C_uc002wfe.2_Silent_p.V213V|NSFL1C_uc002wff.2_RNA|NSFL1C_uc010gag.2_Silent_p.V10V	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	244	SEP.					chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						CTTTGGGCTTCACAAAGTCCT	0.567													1	0	2.1089e-46	0.01441	2.31557e-46	79	84										A	1433191	C	A	1433191	2	1	61	1	0	0	0	0	0	0	0	1	10672	813	29	3		3	NSFL1C	20	1433191	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		1433191	61592329	381	17883										
TMC2	117532	broad.mit.edu	37	chr20	2582792	2582792	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	atgaacaagagagtaacaaaGaagaaaatatccatctgaca	7	6	1	5			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:2582792G>C	uc002wgf.1	+	11	1273	c.1258G>C	c.(1258-1260)GAA>CAA	p.E420Q	TMC2_uc002wgg.1_Missense_Mutation_p.E404Q|TMC2_uc010zpw.1_Missense_Mutation_p.E252Q|TMC2_uc010zpx.1_Missense_Mutation_p.E251Q	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	420	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GAGTAACAAAGAAGAAAATAT	0.403													0	0	0	0.01441	0	40	32										C	2582792	G	C	2582792	3	2	61	1	0	0	0	0	1	0	0	0	15982	943	33	1	1300	1	TMC2	20	2582792	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1149601	2582792	60442728	382	17884										
TRMT6	51605	broad.mit.edu	37	chr20	5927104	5927104	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgtagacttcctccactggtCacttcaaatgcagttccata	6	12	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:5927104C>T	uc002wmh.1	-	2	326	c.204G>A	c.(202-204)GTG>GTA	p.V68V	TRMT6_uc010zra.1_5'UTR|TRMT6_uc010gbn.1_5'UTR|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	68					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						CTCCACTGGTCACTTCAAATG	0.418													0	0	0	0.003755	0	31	55										T	5927104	C	T	5927104	2	4	61	1	0	0	0	0	0	0	0	1	16565	813	29	1		1	TRMT6	20	5927104	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3344312	5927104	57098416	383	17885										
PAK7	57144	broad.mit.edu	37	chr20	9520184	9520184	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agttttaagaatggatgtccGaggagttcctgggctgttgc	14	6	0	1	rs141553527		TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:9520184G>A	uc002wnl.2	-	11	2630	c.2085C>T	c.(2083-2085)CTC>CTT	p.L695L	PAK7_uc002wnk.2_Silent_p.L695L|PAK7_uc002wnj.2_Silent_p.L695L|PAK7_uc010gby.1_Silent_p.L608L	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	695	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ATGGATGTCCGAGGAGTTCCT	0.512													0	0	0	0.01441	0	87	137										A	9520184	G	A	9520184	2	1	61	1	0	0	0	0	0	0	0	1	11405	1045	37	1		1	PAK7	20	9520184	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	3593080	9520184	53505336	384	17886										
MKKS	8195	broad.mit.edu	37	chr20	10389350	10389350	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgttgcttcattaggaataaGatgaaaaaaatgtttggagc	10	3	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:10389350G>A	uc002wnt.1	-	4	1974	c.1087C>T	c.(1087-1089)CTT>TTT	p.L363F	MKKS_uc002wnu.1_Missense_Mutation_p.L363F|MKKS_uc010zrd.1_RNA	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	363	Substrate-binding apical domain.				brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						TTAGGAATAAGATGAAAAAAA	0.398									Bardet-Biedl_syndrome				0	0	0	0.00278	0	23	32										A	10389350	G	A	10389350	3	1	61	1	0	0	0	0	1	0	0	0	9600	942	33	1	637	1	MKKS	20	10389350	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	869166	10389350	52636170	385	17887										
GTSF1L	149699	broad.mit.edu	37	chr20	42354926	42354926	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gatcttctggggactggtctCtcttgctgactctttcgtgt	11	10	5	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:42354926C>G	uc002xld.2	-	1	717	c.409G>C	c.(409-411)GAG>CAG	p.E137Q	GTSF1L_uc002xlc.2_Missense_Mutation_p.E112Q	NM_176791	NP_789761	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like isoform 1	137							metal ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GGACTGGTCTCTCTTGCTGAC	0.368													0	0	0	0.01441	0	67	39										G	42354926	C	G	42354926	3	3	61	1	0	0	0	0	1	0	0	0	6887	922	32	1	41	1	GTSF1L	20	42354926	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	31965576	42354926	20670594	386	17888										
SLC35C2	51006	broad.mit.edu	37	chr20	44984459	44984459	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	accagctcctccagcttgaaGatcagagagaagatcaagat	9	10	2	6			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:44984459G>T	uc002xro.2	-	5	931	c.390C>A	c.(388-390)ATC>ATA	p.I130I	SLC35C2_uc002xrp.2_Silent_p.I130I|SLC35C2_uc002xrq.2_Silent_p.I130I|SLC35C2_uc002xrr.2_Silent_p.I130I|SLC35C2_uc010zxn.1_Silent_p.I16I|SLC35C2_uc010zxo.1_Silent_p.I16I|SLC35C2_uc010zxp.1_Silent_p.I159I	NM_173179	NP_775271	Q9NQQ7	S35C2_HUMAN	solute carrier family 35, member C2 isoform a	130					transport	integral to membrane				ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCAGCTTGAAGATCAGAGAGA	0.517													1	0	2.29192e-23	0.01441	2.47246e-23	45	123										T	44984459	G	T	44984459	2	4	61	1	0	0	0	0	0	0	0	1	14580	932	33	3		3	SLC35C2	20	44984459	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2629533	44984459	18041061	387	17889										
PREX1	57580	broad.mit.edu	37	chr20	47260976	47260976	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctcgtcgctgcccaagtagGagctgttacttctcacgctg	10	13	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:47260976G>C	uc002xtw.1	-	27	3595	c.3572C>G	c.(3571-3573)TCC>TGC	p.S1191C	PREX1_uc002xtv.1_Missense_Mutation_p.S488C	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1191					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCCCAAGTAGGAGCTGTTACT	0.562													0	0	0	0.006999	0	30	24										C	47260976	G	C	47260976	3	2	61	1	0	0	0	0	1	0	0	0	12476	1174	41	1	1463	1	PREX1	20	47260976	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2276517	47260976	15764544	388	17890										
STAU1	6780	broad.mit.edu	37	chr20	47736621	47736621	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcattgcgcttggccaccttCttgttggtgcccgttccttc	10	14	1	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:47736621C>G	uc002xud.2	-	9	1422	c.1011G>C	c.(1009-1011)AAG>AAC	p.K337N	STAU1_uc002xua.2_Missense_Mutation_p.K256N|STAU1_uc002xub.2_Missense_Mutation_p.K262N|STAU1_uc002xuc.2_Missense_Mutation_p.K256N|STAU1_uc002xue.2_Missense_Mutation_p.K256N|STAU1_uc002xuf.2_Missense_Mutation_p.K262N|STAU1_uc002xug.2_Missense_Mutation_p.K337N	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	337	DRBM 3.					microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TGGCCACCTTCTTGTTGGTGC	0.522													0	0	0	0.01441	0	41	19										G	47736621	C	G	47736621	3	3	61	1	0	0	0	0	1	0	0	0	15271	912	32	1	746	1	STAU1	20	47736621	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	475645	47736621	15288899	389	17891										
MOCS3	27304	broad.mit.edu	37	chr20	49576100	49576100	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	agacagtgaccaactgcgcgGacggcggggtgctcggtgtc	17	11	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:49576100G>A	uc002xvy.1	+	1	738	c.721G>A	c.(721-723)GAC>AAC	p.D241N	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	241					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						CAACTGCGCGGACGGCGGGGT	0.622													0	0	0	0.01441	0	64	173										A	49576100	G	A	49576100	3	1	61	1	0	0	0	0	1	0	0	0	9692	1174	41	1	723	1	MOCS3	20	49576100	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1839479	49576100	13449420	390	17892										
ZFP64	55734	broad.mit.edu	37	chr20	50769825	50769825	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttgatacggatgtgcgacttGaggttccccttcatggtgca	12	9	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:50769825G>C	uc002xwl.2	-	6	1255	c.906C>G	c.(904-906)CTC>CTG	p.L302L	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Silent_p.L300L|ZFP64_uc002xwn.2_Silent_p.L248L	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	302	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGTGCGACTTGAGGTTCCCCT	0.557													0	0	0	0.01441	0	45	147										C	50769825	G	C	50769825	2	2	61	1	0	0	0	0	0	0	0	1	17649	1277	45	1		1	ZFP64	20	50769825	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1193725	50769825	12255695	391	17893										
CTCFL	140690	broad.mit.edu	37	chr20	56090809	56090809	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcgtttcagcttgtaggtatCtctgctggcatagctgcact	11	10	2	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:56090809C>G	uc010gix.1	-	5	1803	c.1141G>C	c.(1141-1143)GAT>CAT	p.D381H	CTCFL_uc010giw.1_Missense_Mutation_p.D381H|CTCFL_uc002xym.2_Missense_Mutation_p.D381H|CTCFL_uc010giz.1_5'UTR|CTCFL_uc010giy.1_5'UTR|CTCFL_uc010gja.1_Missense_Mutation_p.D381H|CTCFL_uc010gjb.1_Missense_Mutation_p.D381H|CTCFL_uc010gjc.1_Missense_Mutation_p.D381H|CTCFL_uc010gjd.1_Missense_Mutation_p.D381H|CTCFL_uc010gje.2_Missense_Mutation_p.D381H|CTCFL_uc010gjf.2_Missense_Mutation_p.D176H|CTCFL_uc010gjg.2_Missense_Mutation_p.D113H|CTCFL_uc010gjh.1_Intron|CTCFL_uc010gji.1_Missense_Mutation_p.D176H|CTCFL_uc010gjj.1_Missense_Mutation_p.D381H	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	381	C2H2-type 5.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TTGTAGGTATCTCTGCTGGCA	0.478													0	0	0	0.01441	0	174	105										G	56090809	C	G	56090809	3	3	61	1	0	0	0	0	1	0	0	0	4001	913	32	1	874	1	CTCFL	20	56090809	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5320984	56090809	6934711	392	17894										
TAF4	6874	broad.mit.edu	37	chr20	60582637	60582637	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caaggtaaggttgaggtgaaGaattaagttctcggtataac	12	4	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:60582637G>A	uc002ybs.2	-	6	1940	c.1940C>T	c.(1939-1941)TCT>TTT	p.S647F		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	647	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTGAGGTGAAGAATTAAGTTC	0.458													0	0	0	0.01441	0	134	75										A	60582637	G	A	60582637	3	1	61	1	0	0	0	0	1	0	0	0	15523	942	33	1	1357	1	TAF4	20	60582637	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4491828	60582637	2442883	393	17895										
ARFGAP1	55738	broad.mit.edu	37	chr20	61910306	61910306	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cgccaccgcctcagaagaaaGaagatgacttcctcaacaac	7	14	2	5			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr20:61910306G>C	uc002yem.2	+	7	698	c.586G>C	c.(586-588)GAA>CAA	p.E196Q	ARFGAP1_uc011aas.1_Missense_Mutation_p.E143Q|ARFGAP1_uc011aat.1_Missense_Mutation_p.E83Q|ARFGAP1_uc002yel.2_Missense_Mutation_p.E196Q|ARFGAP1_uc002yen.2_Missense_Mutation_p.E196Q	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	196					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					TCAGAAGAAAGAAGATGACTT	0.597													0	0	0	0.01441	0	63	23										C	61910306	G	C	61910306	3	2	61	1	0	0	0	0	1	0	0	0	849	943	33	1	608	1	ARFGAP1	20	61910306	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1327669	61910306	1115214	394	17896										
MX2	4600	broad.mit.edu	37	chr21	42752066	42752066	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	accctggccaggtggagaaaGagatacacaaaggtgggccc	14	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr21:42752066G>C	uc002yzf.1	+	4	669	c.565G>C	c.(565-567)GAG>CAG	p.E189Q	MX2_uc011aer.1_Intron	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	189					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GGTGGAGAAAGAGATACACAA	0.577													0	0	0	0.00874	0	33	9										C	42752066	G	C	42752066	3	2	61	1	0	0	0	0	1	0	0	0	9998	943	33	1	575	1	MX2	21	42752066	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		42752066	5377829	395	17897										
RRP1B	23076	broad.mit.edu	37	chr21	45093792	45093792	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tttggcaaaccatgaatcgaGaatggaaaggaatagacagg	12	5	0	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr21:45093792G>A	uc002zdk.2	+	4	427	c.313G>A	c.(313-315)GAA>AAA	p.E105K		NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	105					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		CATGAATCGAGAATGGAAAGG	0.408													0	0	0	0.013114	0	40	6										A	45093792	G	A	45093792	3	1	61	1	0	0	0	0	1	0	0	0	13688	943	33	1	327	1	RRP1B	21	45093792	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2341726	45093792	3036103	396	17898										
KRTAP10-7	386675	broad.mit.edu	37	chr21	46020560	46020560	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tctgtctgctccagcgacctGagctacggcagccgcgtctg	12	15	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr21:46020560G>A	uc002zfn.3	+	1	64	c.39G>A	c.(37-39)CTG>CTA	p.L13L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	keratin associated protein 10-7	13						keratin filament					0						CCAGCGACCTGAGCTACGGCA	0.537													0	0	0	0.012213	0	24	31										A	46020560	G	A	46020560	2	1	61	1	0	0	0	0	0	0	0	1	8514	1277	45	1		1	KRTAP10-7	21	46020560	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	926768	46020560	2109335	397	17899										
COL6A1	1291	broad.mit.edu	37	chr21	47419594	47419594	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cccccaggacaccaaggaccGcctgggccggacgtaagtgg	14	15	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr21:47419594G>A	uc002zhu.1	+	27	1866	c.1764G>A	c.(1762-1764)CCG>CCA	p.P588P	COL6A1_uc010gqd.1_5'UTR|COL6A1_uc002zhv.1_5'Flank|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	588	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	ACCAAGGACCGCCTGGGCCGG	0.632													0	0	0	0.010504	0	17	17										A	47419594	G	A	47419594	2	1	61	1	0	0	0	0	0	0	0	1	3699	1074	38	2		2	COL6A1	21	47419594	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1399034	47419594	710301	398	17900										
PCNT	5116	broad.mit.edu	37	chr21	47855826	47855826	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gttaacaacagcgagaattaGaactgcagcgtcagcgtgac	11	9	1	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr21:47855826G>A	uc002zji.3	+	39	8868	c.8761G>A	c.(8761-8763)GAA>AAA	p.E2921K	PCNT_uc002zjj.2_Missense_Mutation_p.E2724K	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2921	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCGAGAATTAGAACTGCAGCG	0.433													0	0	0	0.012319	0	20	38										A	47855826	G	A	47855826	3	1	61	1	0	0	0	0	1	0	0	0	11590	943	33	1	8915	1	PCNT	21	47855826	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	436232	47855826	274069	399	17901										
TUBA8	51807	broad.mit.edu	37	chr22	18561373	18561373	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcagaggaacccgcgggcacGtacgtgctgggctcggaaat	16	11	0	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:18561373G>C	uc002znr.2	+	1	687	c.-336_splice	c.e1+1		PEX26_uc002znp.3_Splice_Site_p.T77_splice|PEX26_uc002znq.3_Splice_Site_p.T77_splice|uc002zns.2_Nonsense_Mutation_p.Y50*|PEX26_uc002znt.2_Splice_Site_p.T77_splice	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8						microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0						CCGCGGGCACGTACGTGCTGG	0.647													0	0	0	0.001168	0	5	7										C	18561373	G	C	18561373	5	2	61	1	0	0	0	0	0	0	1	0	16747	1159	40	4		4	TUBA8	22	18561373	Splice_Site	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08		18561373	32743193	400	17902										
SEPT5	5413	broad.mit.edu	37	chr22	19709361	19709361	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gcagtggagaaccaggcgcaTtgcgacttcgtgaagctgcg	15	10	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:19709361T>C	uc002zpv.1	+	10	956	c.831T>C	c.(829-831)CAT>CAC	p.H277H	SEPT5_uc002zpw.1_RNA|SEPT5_uc002zpx.1_RNA|SEPT5_uc002zpy.1_5'UTR|SEPT5_uc002zpz.1_5'Flank	NM_002688	NP_002679	Q99719	SEPT5_HUMAN	septin 5	277					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)	1	Colorectal(54;0.0993)					ACCAGGCGCATTGCGACTTCG	0.632													0	0	0	0.001984	0	7	62										C	19709361	T	C	19709361	2	2	61	1	0	0	0	0	0	0	0	1	14067	1490	52	5		5	SEPT5	22	19709361	Silent	SNP	T	TCGA-DK-A3IS-01A-21D-A21A-08	1147988	19709361	31595205	401	17903										
ARVCF	421	broad.mit.edu	37	chr22	19961739	19961739	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	gaggtagagacgtaccacctCgggctggtacagcagctcaa	13	11	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:19961739C>T	uc002zqz.2	-	12	2255	c.1984G>A	c.(1984-1986)GAG>AAG	p.E662K	ARVCF_uc002zqy.2_Missense_Mutation_p.E178K	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	662	ARM 7.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					CGTACCACCTCGGGCTGGTAC	0.632													0	0	0	0.006122	0	15	16										T	19961739	C	T	19961739	3	4	61	1	0	0	0	0	1	0	0	0	1003	893	31	1	936	1	ARVCF	22	19961739	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	252378	19961739	31342827	402	17904										
SERPIND1	3053	broad.mit.edu	37	chr22	21133814	21133814	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcaccaacgactggattccaGagggggaggaggacgacgac	15	10	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:21133814G>C	uc002ztb.1	+	2	281	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.E100Q	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	72	Chemotactic activity.				blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CTGGATTCCAGAGGGGGAGGA	0.517													0	0	0	0.007291	0	23	42										C	21133814	G	C	21133814	3	2	61	1	0	0	0	0	1	0	0	0	14110	943	33	1	216	1	SERPIND1	22	21133814	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1172075	21133814	30170752	403	17905										
GAL3ST1	9514	broad.mit.edu	37	chr22	30950948	30950948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcggtgggacgtcaccaccGcaggaaatcgcgaatgaact	14	11	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:30950948G>A	uc003aig.1	-	4	1404	c.1264C>T	c.(1264-1266)CGG>TGG	p.R422W	GAL3ST1_uc003aih.1_Missense_Mutation_p.R422W|GAL3ST1_uc003aii.1_Missense_Mutation_p.R422W|GAL3ST1_uc010gvz.1_Missense_Mutation_p.R422W	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	422	Lumenal (Potential).			R -> E (in Ref. 1; AA sequence).	protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CGTCACCACCGCAGGAAATCG	0.687													0	0	0	0.009096	0	3	22										A	30950948	G	A	30950948	3	1	61	1	0	0	0	0	1	0	0	0	6197	1086	38	2	11	2	GAL3ST1	22	30950948	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	9817134	30950948	20353618	404	17906										
EIF3L	51386	broad.mit.edu	37	chr22	38245481	38245481	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cttatcccgctgatgattatGagtctgaggtaaggtggccg	13	8	1	4			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:38245481G>A	uc003auf.2	+	1	112	c.25G>A	c.(25-27)GAG>AAG	p.E9K	EIF3L_uc003aue.1_Missense_Mutation_p.E9K|EIF3L_uc011ann.1_Missense_Mutation_p.E9K|EIF3L_uc003aug.2_5'Flank|MIR659_hsa-mir-659|MI0003683_5'Flank	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	9						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						TGATGATTATGAGTCTGAGGT	0.647													0	0	0	0.01441	0	100	150										A	38245481	G	A	38245481	3	1	61	1	0	0	0	0	1	0	0	0	5022	1291	45	1	27	1	EIF3L	22	38245481	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	7294533	38245481	13059085	405	17907										
SREBF2	6721	broad.mit.edu	37	chr22	42280950	42280950	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcccaccgagcacactggttGagatccatctgactgctgcc	9	15	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chr22:42280950G>C	uc003bbi.2	+	11	2312	c.2143G>C	c.(2143-2145)GAG>CAG	p.E715Q	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	715	Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						CACACTGGTTGAGATCCATCT	0.587													0	0	0	0.01441	0	41	56										C	42280950	G	C	42280950	3	2	61	1	0	0	0	0	1	0	0	0	15141	1291	45	1	2185	1	SREBF2	22	42280950	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	4035469	42280950	9023616	406	17908										
CLCN4	1183	broad.mit.edu	37	chrX	10188910	10188910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcggcagtgcctggtgacgCggagcgggtgagtagccgga	19	9	0	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:10188910C>T	uc004csy.3	+	12	2615	c.2185C>T	c.(2185-2187)CGG>TGG	p.R729W	CLCN4_uc011mid.1_Missense_Mutation_p.R635W	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	729	CBS 2.|Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CCTGGTGACGCGGAGCGGGTG	0.423													0	0	0	0.01441	0	47	4										T	10188910	C	T	10188910	3	4	61	1	0	0	0	0	1	0	0	0	3465	759	27	2	2223	2	CLCN4	23	10188910	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08		10188910	145081650	407	17909										
FAM48B2	170067	broad.mit.edu	37	chrX	24330063	24330063	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggggaggtggatgtttctctCccttcccggatactgaagac	13	10	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:24330063C>G	uc011mjw.1	-	1	1370	c.1370G>C	c.(1369-1371)GGA>GCA	p.G457A		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	457											0						ATGTTTCTCTCCCTTCCCGGA	0.547													0	0	0	0.008871	0	16	2										G	24330063	C	G	24330063	3	3	61	1	0	0	0	0	1	0	0	0	5574	855	30	1	1086	1	FAM48B2	23	24330063	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	14141153	24330063	130940497	408	17910										
IL1RAPL1	11141	broad.mit.edu	37	chrX	29959767	29959767	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	attgtggttttttctttctaGagctaatgtacacagtggaa	9	5	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:29959767G>C	uc004dby.2	+	9	1566	c.1058_splice	c.e9-1	p.E353_splice		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1						innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TTTCTTTCTAGAGCTAATGTA	0.363													0	0	0	0.01441	0	99	5										C	29959767	G	C	29959767	5	2	61	1	0	0	0	0	0	0	1	0	7661	956	33	1	1087	1	IL1RAPL1	23	29959767	Splice_Site	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	5629704	29959767	125310793	409	17911										
KDM6A	7403	broad.mit.edu	37	chrX	44894182	44894182	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctctcgtcttgcagcattttCagttagctttggttgactgt	9	9	3	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:44894182C>T	uc004dge.3	+	7	946	c.571C>T	c.(571-573)CAG>TAG	p.Q191*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q191*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q191*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q191*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q191*|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	191	TPR 3.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GCAGCATTTTCAGTTAGCTTT	0.343			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.01441	0	49	2										T	44894182	C	T	44894182	4	4	61	1	0	0	0	0	0	1	0	0	8137	827	29	1	597	1	KDM6A	23	44894182	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	14934415	44894182	110376378	410	17912										
WDR13	64743	broad.mit.edu	37	chrX	48457331	48457331	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tccgcagtagccgcactactCttgaccgcatggaggtgagc	12	13	1	2			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:48457331C>T	uc004dkh.1	+	3	415	c.268C>T	c.(268-270)CTT>TTT	p.L90F	WDR13_uc010nif.1_Intron|WDR13_uc004dki.1_5'UTR|WDR13_uc004dkj.1_Missense_Mutation_p.L90F|WDR13_uc004dkk.1_5'UTR|WDR13_uc004dkl.3_5'UTR|WDR13_uc011mme.1_5'Flank	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	90						cytoplasm|nucleus				ovary(2)	2						CCGCACTACTCTTGACCGCAT	0.522													0	0	0	0.003755	0	31	4										T	48457331	C	T	48457331	3	4	61	1	0	0	0	0	1	0	0	0	17272	913	32	1	274	1	WDR13	23	48457331	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	3563149	48457331	106813229	411	17913										
ITIH5L	347365	broad.mit.edu	37	chrX	54783589	54783589	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgccttctggtgtaggcctgGagctgttgagtaggctcatt	14	8	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:54783589G>A	uc004dtj.2	-	8	2948	c.2918C>T	c.(2917-2919)TCC>TTC	p.S973F		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	973	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						TGTAGGCCTGGAGCTGTTGAG	0.572													0	0	0	0.005443	0	24	0										A	54783589	G	A	54783589	3	1	61	1	0	0	0	0	1	0	0	0	7908	1174	41	1	1047	1	ITIH5L	23	54783589	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	6326258	54783589	100486971	412	17914										
TEX11	56159	broad.mit.edu	37	chrX	70099855	70099855	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	aacctgaatgtctgttatttCagccatagactccctgttga	7	10	2	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:70099855C>A	uc004dyl.2	-	4	349	c.187G>T	c.(187-189)GAA>TAA	p.E63*	TEX11_uc004dym.2_Nonsense_Mutation_p.E48*	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	63							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TCTGTTATTTCAGCCATAGAC	0.313													1	0	9.31168e-06	0.001855	9.60389e-06	10	20										A	70099855	C	A	70099855	4	1	61	1	0	0	0	0	0	1	0	0	15771	835	29	3	2747	3	TEX11	23	70099855	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	15316266	70099855	85170705	413	17915										
MED12	9968	broad.mit.edu	37	chrX	70360617	70360617	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	cagcagcagcaacagcagcaAcagcaacagcagcagcagca	10	14	0	0			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:70360617A>G	uc004dyy.2	+	42	6376	c.6177A>G	c.(6175-6177)CAA>CAG	p.Q2059Q	MED12_uc004dyz.2_Silent_p.Q2058Q|MED12_uc004dza.2_Silent_p.Q1909Q|MED12_uc010nla.2_Silent_p.Q688Q	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	2059	Gln-rich.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					aacagcagcaacagcaacagc	0.259													0	0	0	0.003163	0	9	22										G	70360617	A	G	70360617	2	3	61	1	0	0	0	0	0	0	0	1	9428	40	2	5		5	MED12	23	70360617	Silent	SNP	A	TCGA-DK-A3IS-01A-21D-A21A-08	260762	70360617	84909943	414	17916										
PHKA1	5255	broad.mit.edu	37	chrX	71843049	71843049	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttcactgtacagcttaccctCaggtccagggtccatgaagc	9	13	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:71843049C>T	uc004eax.3	-	18	2171	c.1870G>A	c.(1870-1872)GAG>AAG	p.E624K	PHKA1_uc004eay.3_Missense_Mutation_p.E624K|PHKA1_uc011mqi.1_Missense_Mutation_p.E624K	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	624					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					AGCTTACCCTCAGGTCCAGGG	0.408													0	0	0	0.00874	0	38	1										T	71843049	C	T	71843049	3	4	61	1	0	0	0	0	1	0	0	0	11843	835	29	1	1861	1	PHKA1	23	71843049	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	1482432	71843049	83427511	415	17917										
WDR44	54521	broad.mit.edu	37	chrX	117566847	117566847	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgctgatctccttgatctttCatggtctaaagtaagaaatt	7	7	4	3			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:117566847C>T	uc004eqn.2	+	13	2266	c.1841C>T	c.(1840-1842)TCA>TTA	p.S614L	WDR44_uc004eqo.2_Missense_Mutation_p.S614L|WDR44_uc011mtr.1_Missense_Mutation_p.S589L|WDR44_uc010nqi.2_Missense_Mutation_p.S324L	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	614	WD 2.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CTTGATCTTTCATGGTCTAAA	0.284													0	0	0	0.01441	0	47	4										T	117566847	C	T	117566847	3	4	61	1	0	0	0	0	1	0	0	0	17293	838	29	1	1891	1	WDR44	23	117566847	Missense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	45723798	117566847	37703713	416	17918										
STAG2	10735	broad.mit.edu	37	chrX	123197011	123197011	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ctaacttgttgcagttgcctCagtactttgatttggaaata	8	7	1	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:123197011C>T	uc004etz.3	+	18	2116	c.1777C>T	c.(1777-1779)CAG>TAG	p.Q593*	STAG2_uc004eua.2_Nonsense_Mutation_p.Q593*|STAG2_uc004eub.2_Nonsense_Mutation_p.Q593*|STAG2_uc004euc.2_Nonsense_Mutation_p.Q593*|STAG2_uc004eud.2_Nonsense_Mutation_p.Q593*|STAG2_uc004eue.2_Nonsense_Mutation_p.Q593*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	593					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GCAGTTGCCTCAGTACTTTGA	0.279													0	0	0	0.004656	0	20	2										T	123197011	C	T	123197011	4	4	61	1	0	0	0	0	0	1	0	0	15242	827	29	1	1843	1	STAG2	23	123197011	Nonsense_Mutation	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	5630164	123197011	32073549	417	17919										
ODZ1	10178	broad.mit.edu	37	chrX	124097480	124097480	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tcgtgcagggtctccctggaGttgtatgactgtcttggttt	13	8	2	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:124097480G>A	uc004euj.2	-	1	187	c.123C>T	c.(121-123)AAC>AAT	p.N41N	ODZ1_uc011muj.1_Silent_p.N41N|ODZ1_uc010nqy.2_Silent_p.N41N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	41	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCTCCCTGGAGTTGTATGACT	0.428													0	0	0	0.01441	0	55	77										A	124097480	G	A	124097480	2	1	61	1	0	0	0	0	0	0	0	1	10834	1020	36	2		2	ODZ1	23	124097480	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	900469	124097480	31173080	418	17920										
HTATSF1	27336	broad.mit.edu	37	chrX	135593753	135593753	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	tgttagatgaggaaggctctGagagagagtttgacgaagat	15	3	1	6			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:135593753G>C	uc004ezw.2	+	10	2271	c.1849G>C	c.(1849-1851)GAG>CAG	p.E617Q	HTATSF1_uc004ezx.2_Missense_Mutation_p.E617Q	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	617	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GGAAGGCTCTGAGAGAGAGTT	0.363													0	0	0	0.005524	0	33	5										C	135593753	G	C	135593753	3	2	61	1	0	0	0	0	1	0	0	0	7433	1291	45	1	1883	1	HTATSF1	23	135593753	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	11496273	135593753	19676807	419	17921										
GABRE	2564	broad.mit.edu	37	chrX	151123200	151123200	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ttaaggcaaacaagccagtaGagcacattgaagaagaagaa	10	6	0	5			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:151123200G>C	uc004ffi.2	-	9	1548	c.1494C>G	c.(1492-1494)CTC>CTG	p.L498L	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	498	Helical; (Potential).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAAGCCAGTAGAGCACATTGA	0.547													0	0	0	0.010729	0	11	3										C	151123200	G	C	151123200	2	2	61	1	0	0	0	0	0	0	0	1	6170	929	33	1		1	GABRE	23	151123200	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	15529447	151123200	4147360	420	17922										
MAGEA10	4109	broad.mit.edu	37	chrX	151303448	151303448	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggcatgctctggacatcactCagcatcccatcataggtgag	10	12	4	1			TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:151303448C>T	uc004ffk.2	-	5	1053	c.645G>A	c.(643-645)CTG>CTA	p.L215L	MAGEA10_uc004ffl.2_Silent_p.L215L	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	215	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGACATCACTCAGCATCCCAT	0.522													0	0	0	0.01441	0	49	8										T	151303448	C	T	151303448	2	4	61	1	0	0	0	0	0	0	0	1	9164	813	29	1		1	MAGEA10	23	151303448	Silent	SNP	C	TCGA-DK-A3IS-01A-21D-A21A-08	180248	151303448	3967112	421	17923										
BGN	633	broad.mit.edu	37	chrX	152770152	152770152	+	Silent	SNP	G	G	A													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	caggccctgccctttgagcaGagaggcttctgggacttcac							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:152770152G>A	uc004fhr.1	+	2	235	c.63G>A	c.(61-63)CAG>CAA	p.Q21Q	BGN_uc004fhq.1_RNA	NM_001711	NP_001702	P21810	PGS1_HUMAN	biglycan preproprotein	21						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTTTGAGCAGAGAGGCTTCT	0.642													0	0	0	0.005524	0	34	1										A	152770152	G	A	152770152	2	1	61	1	0	0	0	0	0	0	0	1	1418	933	33	1		1	BGN	23	152770152	Silent	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	1466704	152770152	2500408	422	17924	87	2								
BGN	633	broad.mit.edu	37	chrX	152770154	152770154	+	Missense_Mutation	SNP	G	G	A													0.516666666666667	217	4.15343198029819e-83	4.16087097822554	5.01988950276243	3.6384948484396	0.095107980269964	0.217754357439058	165	ggccctgccctttgagcagaGaggcttctgggacttcaccc							TCGA-DK-A3IS-01A-21D-A21A-08	TCGA-DK-A3IS-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	92a59313-da12-4896-b164-fd2d50684638	f4a45c39-9014-43d9-a791-9fe0bb5155ba	g.chrX:152770154G>A	uc004fhr.1	+	2	237	c.65G>A	c.(64-66)AGA>AAA	p.R22K	BGN_uc004fhq.1_RNA	NM_001711	NP_001702	P21810	PGS1_HUMAN	biglycan preproprotein	22						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTTGAGCAGAGAGGCTTCTGG	0.642													0	0	0	0.010771	0	39	1										A	152770154	G	A	152770154	3	1	61	1	0	0	0	0	1	0	0	0	1418	942	33	1	67	1	BGN	23	152770154	Missense_Mutation	SNP	G	TCGA-DK-A3IS-01A-21D-A21A-08	2	152770154	2500406	423	17925	87	2								
PLEKHG5	57449	broad.mit.edu	37	chr1	6534204	6534204	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccctgctccaccttgccctCatctccaggcttggctgggg	11	17	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:6534204C>G	uc001ano.1	-	8	729	c.628G>C	c.(628-630)GAG>CAG	p.E210Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.E191Q|PLEKHG5_uc001anq.1_Missense_Mutation_p.E231Q|PLEKHG5_uc001anp.1_Missense_Mutation_p.E231Q|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Missense_Mutation_p.E223Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.E154Q|PLEKHG5_uc009vmb.1_Missense_Mutation_p.E154Q|PLEKHG5_uc001anl.1_Missense_Mutation_p.E154Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.E154Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	210					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		ACCTTGCCCTCATCTCCAGGC	0.677													0	0	0	0.013537	0	9	35										G	6534204	C	G	6534204	3	3	62	1	0	0	0	0	1	0	0	0	12073	835	29	1	2620	1	PLEKHG5	1	6534204	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		6534204	242716417	1	17926										
TARDBP	23435	broad.mit.edu	37	chr1	11082686	11082686	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctttggctcaagcatggattCtaagtcttctggctggggaa	12	8	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:11082686C>G	uc001art.2	+	6	1354	c.1220C>G	c.(1219-1221)TCT>TGT	p.S407C	TARDBP_uc010oap.1_Missense_Mutation_p.S291C	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	407	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AGCATGGATTCTAAGTCTTCT	0.443													0	0	0	0.007835	0	26	146										G	11082686	C	G	11082686	3	3	62	1	0	0	0	0	1	0	0	0	15554	913	32	1	1238	1	TARDBP	1	11082686	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4548482	11082686	238167935	2	17927										
DNAJC16	23341	broad.mit.edu	37	chr1	15871058	15871058	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatttgtagaaagtcttcttCcagggaacttggtggagaaa	11	5	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15871058C>A	uc001aws.2	+	5	859	c.739C>A	c.(739-741)CCA>ACA	p.P247T	DNAJC16_uc001awr.1_Missense_Mutation_p.P247T|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	247	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAGTCTTCTTCCAGGGAACTT	0.423													1	0	3.7963e-18	0.00333	4.28924e-18	19	89										A	15871058	C	A	15871058	3	1	62	1	0	0	0	0	1	0	0	0	4635	855	30	3	753	3	DNAJC16	1	15871058	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4788372	15871058	233379563	3	17928										
DNAJC16	23341	broad.mit.edu	37	chr1	15890809	15890809	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcgatggttctactctgcttCtgactacatctcagactgct	7	12	4	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15890809C>G	uc001aws.2	+	11	1673	c.1553C>G	c.(1552-1554)TCT>TGT	p.S518C	DNAJC16_uc001awr.1_Missense_Mutation_p.S518C|DNAJC16_uc001awt.2_Missense_Mutation_p.S206C|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	518	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TACTCTGCTTCTGACTACATC	0.433													0	0	0	0.004289	0	28	130										G	15890809	C	G	15890809	3	3	62	1	0	0	0	0	1	0	0	0	4635	913	32	1	1591	1	DNAJC16	1	15890809	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	19751	15890809	233359812	4	17929										
KDM1A	23028	broad.mit.edu	37	chr1	23395118	23395118	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttagtcatcaactagacttCaatgtcctcaataataagcc	4	11	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:23395118C>T	uc001bgi.2	+	9	1343	c.1194C>T	c.(1192-1194)TTC>TTT	p.F398F	KDM1A_uc001bgj.2_Silent_p.F422F	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	398	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						AACTAGACTTCAATGTCCTCA	0.398													0	0	0	0.007413	0	18	28										T	23395118	C	T	23395118	2	4	62	1	0	0	0	0	0	0	0	1	8122	825	29	1		1	KDM1A	1	23395118	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7504309	23395118	225855503	5	17930										
GJB3	2707	broad.mit.edu	37	chr1	35250591	35250591	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccatctccaacatccgcctCtgggccctgcagctcatctt	6	19	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:35250591C>T	uc001bxx.2	+	2	843	c.228C>T	c.(226-228)CTC>CTT	p.L76L	GJB3_uc001bxy.2_Silent_p.L76L|GJB3_uc001bxz.3_Silent_p.L76L|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	76	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				ACATCCGCCTCTGGGCCCTGC	0.622													0	0	0	0.010729	0	12	22										T	35250591	C	T	35250591	2	4	62	1	0	0	0	0	0	0	0	1	6409	900	32	1		1	GJB3	1	35250591	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	11855473	35250591	214000030	6	17931										
ZMYM4	9202	broad.mit.edu	37	chr1	35885249	35885249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacttgccaaagccaaatctGaagactctgatgttgaatta	7	8	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:35885249G>C	uc001byt.2	+	30	4698	c.4618G>C	c.(4618-4620)GAA>CAA	p.E1540Q	ZMYM4_uc009vuu.2_Missense_Mutation_p.E1508Q|ZMYM4_uc001byu.2_Missense_Mutation_p.E1216Q|ZMYM4_uc009vuv.2_Missense_Mutation_p.E1279Q	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1540					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCCAAATCTGAAGACTCTGA	0.423													0	0	0	0.001855	0	12	32										C	35885249	G	C	35885249	3	2	62	1	0	0	0	0	1	0	0	0	17699	1291	45	1	4736	1	ZMYM4	1	35885249	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	634658	35885249	213365372	7	17932										
MTF1	4520	broad.mit.edu	37	chr1	38304297	38304297	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tagaaaacagtaagacctacCgaaatggcttttcccctgta	7	10	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:38304297C>T	uc001cce.1	-	4	920	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	260	C2H2-type 5.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAAGACCTACCGAAATGGCTT	0.403													0	0	0	0.00245	0	11	62										T	38304297	C	T	38304297	3	4	62	1	0	0	0	0	1	0	0	0	9922	666	23	2	1514	2	MTF1	1	38304297	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2419048	38304297	210946324	8	17933										
CAP1	10487	broad.mit.edu	37	chr1	40529930	40529930	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cgatttgttggcacccatctCagagcagatcaaagaagtga	10	9	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:40529930C>G	uc001cfa.3	+	5	555	c.326C>G	c.(325-327)TCA>TGA	p.S109*	CAP1_uc001cey.3_Nonsense_Mutation_p.S109*|CAP1_uc001cez.3_Nonsense_Mutation_p.S109*|CAP1_uc009vvz.2_Nonsense_Mutation_p.S109*|CAP1_uc010oje.1_Intron	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	109					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCACCCATCTCAGAGCAGATC	0.448													0	0	0	0.003954	0	21	66										G	40529930	C	G	40529930	4	3	62	1	0	0	0	0	0	1	0	0	2619	838	29	1	340	1	CAP1	1	40529930	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2225633	40529930	208720691	9	17934										
TSPAN1	10103	broad.mit.edu	37	chr1	46651197	46651197	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccatgtatctgtactgcaatCtacaataagtccacttctgc	5	12	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:46651197C>G	uc001cpd.2	+	9	1182	c.718C>G	c.(718-720)CTA>GTA	p.L240V	TSPAN1_uc009vyd.1_Missense_Mutation_p.L240V	NM_005727	NP_005718	O60635	TSN1_HUMAN	tetraspan 1	240	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GTACTGCAATCTACAATAAGT	0.542													0	0	0	0.01441	0	46	236										G	46651197	C	G	46651197	3	3	62	1	0	0	0	0	1	0	0	0	16630	912	32	1	744	1	TSPAN1	1	46651197	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6121267	46651197	202599424	10	17935										
CC2D1B	200014	broad.mit.edu	37	chr1	52824767	52824767	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccgggcctggatgcccgcctCgcggtacttgttcagcctct	12	16	2	0	rs144724390	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:52824767C>G	uc001ctq.1	-	11	1327	c.1189G>C	c.(1189-1191)GAG>CAG	p.E397Q	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_Missense_Mutation_p.E88Q	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	397										ovary(2)	2						ATGCCCGCCTCGCGGTACTTG	0.632													0	0	0	0.006214	0	8	37										G	52824767	C	G	52824767	3	3	62	1	0	0	0	0	1	0	0	0	2727	893	31	1	1443	1	CC2D1B	1	52824767	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6173570	52824767	196425854	11	17936										
CC2D1B	200014	broad.mit.edu	37	chr1	52825538	52825538	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatgccagggaggctggtctCaggttgggaggggttgtcta	18	6	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:52825538C>G	uc001ctq.1	-	8	919	c.781G>C	c.(781-783)GAG>CAG	p.E261Q	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_5'UTR	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	261	Pro-rich.									ovary(2)	2						AGGCTGGTCTCAGGTTGGGAG	0.572													0	0	0	0.009096	0	3	19										G	52825538	C	G	52825538	3	3	62	1	0	0	0	0	1	0	0	0	2727	835	29	1	1863	1	CC2D1B	1	52825538	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	771	52825538	196425083	12	17937										
AK3L1	205	broad.mit.edu	37	chr1	65684501	65684501	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtgaagtggatctagtgatCagtttgaatattccatttga	10	4	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:65684501C>G	uc001dby.2	+	4	577	c.330C>G	c.(328-330)ATC>ATG	p.I110M	AK3L1_uc009wan.2_Missense_Mutation_p.I58M|AK3L1_uc001dbz.2_Missense_Mutation_p.I110M|AK3L1_uc001dca.2_Missense_Mutation_p.I110M	NM_203464	NP_982289	P27144	KAD4_HUMAN	adenylate kinase 3-like 1 isoform 7	110						mitochondrial matrix	adenylate kinase activity|ATP binding|GTP binding				0						ATCTAGTGATCAGTTTGAATA	0.433													0	0	0	0.004482	0	5	47										G	65684501	C	G	65684501	3	3	62	1	0	0	0	0	1	0	0	0	442	816	29	1	340	1	AK3L1	1	65684501	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	12858963	65684501	183566120	13	17938										
C1orf173	127254	broad.mit.edu	37	chr1	75065450	75065450	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcacattgtcacgggcatctGgtgccttctgtgatgaggtt	12	9	4	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:75065450G>A	uc001dgg.2	-	11	1874	c.1655C>T	c.(1654-1656)CCA>CTA	p.P552L	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.P346L	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	552	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ACGGGCATCTGGTGCCTTCTG	0.408													0	0	0	0.009718	0	43	102										A	75065450	G	A	75065450	3	1	62	1	0	0	0	0	1	0	0	0	2014	1348	47	2	2953	2	C1orf173	1	75065450	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	9380949	75065450	174185171	14	17939										
ZZZ3	26009	broad.mit.edu	37	chr1	78034131	78034131	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcaggtaaattcctatacatGataggaatactttcgtcatc	6	8	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:78034131G>C	uc001dhq.2	-	13	2828	c.2352C>G	c.(2350-2352)ATC>ATG	p.I784M	ZZZ3_uc001dhr.2_Missense_Mutation_p.I290M|ZZZ3_uc001dhp.2_Missense_Mutation_p.I783M	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	784					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TCCTATACATGATAGGAATAC	0.269													0	0	0	0.010729	0	12	11										C	78034131	G	C	78034131	3	2	62	1	0	0	0	0	1	0	0	0	18253	1280	45	1	371	1	ZZZ3	1	78034131	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2968681	78034131	171216490	15	17940										
USP33	23032	broad.mit.edu	37	chr1	78187599	78187599	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaaaccagctagggacacatGagacaacaaacctgaaacat	7	10	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:78187599G>A	uc001dht.2	-	15	2014	c.1667C>T	c.(1666-1668)TCA>TTA	p.S556L	USP33_uc001dhs.2_Missense_Mutation_p.S277L|USP33_uc001dhu.2_Missense_Mutation_p.S525L|USP33_uc001dhv.2_Missense_Mutation_p.S361L|USP33_uc001dhw.2_Intron	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	556					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						AGGGACACATGAGACAACAAA	0.373													0	0	0	0.003163	0	14	29										A	78187599	G	A	78187599	3	1	62	1	0	0	0	0	1	0	0	0	17061	1294	45	1	1217	1	USP33	1	78187599	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	153468	78187599	171063022	16	17941										
LPAR3	23566	broad.mit.edu	37	chr1	85279670	85279670	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcctgagagaagcagcagatCatcttcttcatggtgccata	9	10	4	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:85279670C>G	uc001dkl.2	-	2	960	c.921G>C	c.(919-921)ATG>ATC	p.M307I	LPAR3_uc009wcj.1_Missense_Mutation_p.M307I	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	307	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						AGCAGCAGATCATCTTCTTCA	0.547													0	0	0	0.007413	0	16	64										G	85279670	C	G	85279670	3	3	62	1	0	0	0	0	1	0	0	0	8906	826	29	1	144	1	LPAR3	1	85279670	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7092071	85279670	163970951	17	17942										
SH3GLB1	51100	broad.mit.edu	37	chr1	87208005	87208005	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcaacaagtggcctagtaatCacctctccttccaacctcag	5	15	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:87208005C>A	uc001dlw.2	+	8	1202	c.876C>A	c.(874-876)ATC>ATA	p.I292I	SH3GLB1_uc001dlx.2_Silent_p.I313I|SH3GLB1_uc001dly.2_Silent_p.I321I|SH3GLB1_uc001dlz.2_Silent_p.I192I	NM_016009	NP_057093	Q9Y371	SHLB1_HUMAN	SH3-containing protein SH3GLB1	292					anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		GCCTAGTAATCACCTCTCCTT	0.438													1	0	1.30015e-28	0.004878	1.51295e-28	36	47										A	87208005	C	A	87208005	2	1	62	1	0	0	0	0	0	0	0	1	14253	816	29	3		3	SH3GLB1	1	87208005	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1928335	87208005	162042616	18	17943										
LRRC8D	55144	broad.mit.edu	37	chr1	90400866	90400866	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acatttcaatgattccaataGaaataggattgcttcagaac	6	7	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:90400866G>C	uc001dnm.2	+	3	2664	c.2239G>C	c.(2239-2241)GAA>CAA	p.E747Q	LRRC8D_uc001dnn.2_Missense_Mutation_p.E747Q	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	747	LRR 10.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GATTCCAATAGAAATAGGATT	0.373													0	0	0	0.007413	0	19	73										C	90400866	G	C	90400866	3	2	62	1	0	0	0	0	1	0	0	0	9024	943	33	1	2241	1	LRRC8D	1	90400866	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3192861	90400866	158849755	19	17944										
BARHL2	343472	broad.mit.edu	37	chr1	91182500	91182500	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgtggtggaggtggtgatGatgctgggtcgcgtctgcta	19	6	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:91182500G>A	uc001dns.2	-	1	295	c.253C>T	c.(253-255)CAT>TAT	p.H85Y		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	85						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AGGTGGTGATGATGCTGGGTC	0.473													0	0	0	0.008291	0	10	16										A	91182500	G	A	91182500	3	1	62	1	0	0	0	0	1	0	0	0	1314	1290	45	1	922	1	BARHL2	1	91182500	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	781634	91182500	158068121	20	17945										
GCLM	2730	broad.mit.edu	37	chr1	94360257	94360257	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	catcacacagcaggaggcaaGattaacttggttactatttg	9	8	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:94360257G>A	uc001dqg.1	-	6	861	c.568C>T	c.(568-570)CTT>TTT	p.L190F		NM_002061	NP_002052	P48507	GSH0_HUMAN	glutamate-cysteine ligase regulatory protein	190					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CAGGAGGCAAGATTAACTTGG	0.323													0	0	0	0.01441	0	51	87										A	94360257	G	A	94360257	3	1	62	1	0	0	0	0	1	0	0	0	6296	942	33	1	264	1	GCLM	1	94360257	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3177757	94360257	154890364	21	17946										
CSDE1	7812	broad.mit.edu	37	chr1	115262243	115262243	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgcacttgccagtgcgctGattaagaatcactgagaact	10	10	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:115262243G>A	uc001efk.2	-	18	2639	c.2173C>T	c.(2173-2175)CAG>TAG	p.Q725*	NRAS_uc009wgu.2_5'Flank|CSDE1_uc001efi.2_Nonsense_Mutation_p.Q771*|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Nonsense_Mutation_p.Q694*|CSDE1_uc001efm.2_Nonsense_Mutation_p.Q740*|CSDE1_uc009wgv.2_Nonsense_Mutation_p.Q725*|CSDE1_uc001efn.2_Nonsense_Mutation_p.Q694*	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	725	CSD 9.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAGTGCGCTGATTAAGAATC	0.448													0	0	0	0.005443	0	24	101										A	115262243	G	A	115262243	4	1	62	1	0	0	0	0	0	1	0	0	3929	1299	45	1	235	1	CSDE1	1	115262243	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	20901986	115262243	133988378	22	17947										
NBPF10	100132406	broad.mit.edu	37	chr1	145301812	145301812	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagagcagctcaagcaagctGaggagctcaggtgaggggac	16	9	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:145301812G>A	uc001end.3	+	7	1116	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E361K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.E90K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	361											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAAGCAAGCTGAGGAGCTCAG	0.522													0	0	0	0.003954	0	9	179										A	145301812	G	A	145301812	3	1	62	1	0	0	0	0	1	0	0	0	10193	1291	45	1	1107	1	NBPF10	1	145301812	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	30039569	145301812	103948809	23	17948										
FMO5	2330	broad.mit.edu	37	chr1	146672879	146672879	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tacagggatatcttgtttttGaccactttgacggaatcttc	8	8	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:146672879G>C	uc001epi.2	-	7	1427	c.1038C>G	c.(1036-1038)GTC>GTG	p.V346V	FMO5_uc001eph.3_Silent_p.V346V|FMO5_uc001epj.2_Intron	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	346						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					TCTTGTTTTTGACCACTTTGA	0.443													0	0	0	0.001984	0	6	68										C	146672879	G	C	146672879	2	2	62	1	0	0	0	0	0	0	0	1	5958	1277	45	1		1	FMO5	1	146672879	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1371067	146672879	102577742	24	17949										
BCL9	607	broad.mit.edu	37	chr1	147092562	147092562	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaccctctgaagtctcccacGatgcaccaagtccagtcacc	6	17	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:147092562G>A	uc001epq.2	+	8	3341	c.2601G>A	c.(2599-2601)ACG>ACA	p.T867T	BCL9_uc010ozr.1_Silent_p.T793T	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	867	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					AGTCTCCCACGATGCACCAAG	0.637			T	IGH@|IGL@	B-ALL								0	0	0	0.003954	0	23	97										A	147092562	G	A	147092562	2	1	62	1	0	0	0	0	0	0	0	1	1381	1045	37	1		1	BCL9	1	147092562	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	419683	147092562	102158059	25	17950										
HORMAD1	84072	broad.mit.edu	37	chr1	150687152	150687152	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tctcagtattttgacacaaaGatctaaacacaaaaatgatg	5	7	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:150687152G>A	uc001evk.1	-	4	287	c.181C>T	c.(181-183)CTT>TTT	p.L61F	HORMAD1_uc001evl.1_Missense_Mutation_p.L61F|HORMAD1_uc001evm.1_Intron	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	61	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTGACACAAAGATCTAAACAC	0.174													0	0	0	0.007413	0	14	59										A	150687152	G	A	150687152	3	1	62	1	0	0	0	0	1	0	0	0	7286	942	33	1	1051	1	HORMAD1	1	150687152	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3594590	150687152	98563469	26	17951										
SETDB1	9869	broad.mit.edu	37	chr1	150923439	150923439	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcccctatcctgtgtcaatGagattgacacaacccctcca	5	15	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:150923439G>C	uc001evu.2	+	13	2276	c.2086G>C	c.(2086-2088)GAG>CAG	p.E696Q	SETDB1_uc009wmf.2_Missense_Mutation_p.E697Q|SETDB1_uc001evv.2_Missense_Mutation_p.E696Q|SETDB1_uc009wmg.1_Missense_Mutation_p.E696Q	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGTGTCAATGAGATTGACAC	0.468													0	0	0	0.00333	0	16	75										C	150923439	G	C	150923439	3	2	62	1	0	0	0	0	1	0	0	0	14138	1291	45	1	2132	1	SETDB1	1	150923439	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	236287	150923439	98327182	27	17952										
PRUNE	58497	broad.mit.edu	37	chr1	151001306	151001306	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttgcagatctccatgctttCtgccaggctcacagctatga	8	13	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:151001306C>G	uc001ewh.1	+	7	955	c.819C>G	c.(817-819)TTC>TTG	p.F273L	PRUNE_uc001ewi.1_Missense_Mutation_p.F91L|PRUNE_uc010pco.1_Missense_Mutation_p.F41L|PRUNE_uc001ewj.1_Intron|PRUNE_uc001ewk.1_Intron	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	273						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCATGCTTTCTGCCAGGCTC	0.478													0	0	0	0.010504	0	16	109										G	151001306	C	G	151001306	3	3	62	1	0	0	0	0	1	0	0	0	12640	912	32	1	845	1	PRUNE	1	151001306	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	77867	151001306	98249315	28	17953										
TCHH	7062	broad.mit.edu	37	chr1	152081239	152081239	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttcctcctccaggaattttCtgtcacgctcttggcggtgc	10	13	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:152081239C>G	uc001ezp.2	-	2	4454	c.4454G>C	c.(4453-4455)AGA>ACA	p.R1485T	TCHH_uc009wne.1_Missense_Mutation_p.R1485T	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1485	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGGAATTTTCTGTCACGCTC	0.552													0	0	0	0.01441	0	44	147										G	152081239	C	G	152081239	3	3	62	1	0	0	0	0	1	0	0	0	15697	913	32	1	1381	1	TCHH	1	152081239	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1079933	152081239	97169382	29	17954										
RPTN	126638	broad.mit.edu	37	chr1	152128385	152128388	+	Frame_Shift_Del	DEL	TGTC	TGTC	-													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	catagtgagaactttggtctTgtctgtctgtctgaccatag							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:152128385_152128388delTGTC	uc001ezs.1	-	3	1252_1255	c.1187_1190delGACA	c.(1186-1191)AGACAAfs	p.R396fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	396_397	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTTTGGTCTTGTCTGTCTGTCTG	0.505																		8	1501	---	---								-	152128388	TGTC	-	152128385	7	5	62	1	0	1	0	1	0	0	0	0	13664	1812	63	0	1168	0	RPTN	1	152128385	Frame_Shift_Del	DEL	TGTC	TCGA-DK-A3IT-01A-31D-A20D-08	47146	152128385	97122236	30	17955										
INTS3	65123	broad.mit.edu	37	chr1	153713793	153713793	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcccccagcatgaagaaatCtgcctgggcctgtttactct	8	14	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:153713793C>A	uc009wom.2	+	4	488	c.267C>A	c.(265-267)ATC>ATA	p.I89I	INTS3_uc001fct.2_Silent_p.I89I|INTS3_uc001fcu.2_Translation_Start_Site|INTS3_uc001fcv.2_Translation_Start_Site	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	89					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ATGAAGAAATCTGCCTGGGCC	0.493													1	0	5.35047e-06	0.00333	5.57022e-06	18	169										A	153713793	C	A	153713793	2	1	62	1	0	0	0	0	0	0	0	1	7779	903	32	3		3	INTS3	1	153713793	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1585408	153713793	95536828	31	17956										
KCNN3	3782	broad.mit.edu	37	chr1	154841844	154841844	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggccctcagtctcggcctcGatgaggttcctccgggaggc	14	14	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:154841844G>C	uc001ffp.2	-	1	911	c.597C>G	c.(595-597)ATC>ATG	p.I199M	KCNN3_uc009wox.1_Missense_Mutation_p.I199M	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	204						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TCTCGGCCTCGATGAGGTTCC	0.637													0	0	0	0.004482	0	7	61										C	154841844	G	C	154841844	3	2	62	1	0	0	0	0	1	0	0	0	8080	1048	37	1	1652	1	KCNN3	1	154841844	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1128051	154841844	94408777	32	17957										
PAQR6	79957	broad.mit.edu	37	chr1	156215947	156215947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtgagtccagatgttgaccGtctcgttggtcatctggaag	13	8	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156215947G>A	uc001fnu.1	-	3	216	c.146C>T	c.(145-147)ACG>ATG	p.T49M	PAQR6_uc010phf.1_Translation_Start_Site|PAQR6_uc001fny.1_Translation_Start_Site|PAQR6_uc001fnv.1_Missense_Mutation_p.T25M|PAQR6_uc010phg.1_Missense_Mutation_p.T46M|PAQR6_uc001fnx.1_Translation_Start_Site|PAQR6_uc001fnw.1_Translation_Start_Site|PAQR6_uc001fnz.1_Translation_Start_Site|PAQR6_uc010phh.1_Missense_Mutation_p.T49M|PAQR6_uc001foa.1_Translation_Start_Site|PAQR6_uc001fob.1_RNA	NM_198406	NP_940798	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	49	Cytoplasmic (Potential).					integral to membrane	receptor activity				0	Hepatocellular(266;0.158)					GATGTTGACCGTCTCGTTGGT	0.647													0	0	0	0.004656	0	23	43										A	156215947	G	A	156215947	3	1	62	1	0	0	0	0	1	0	0	0	11439	1145	40	2	1251	2	PAQR6	1	156215947	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1374103	156215947	93034674	33	17958										
SMG5	23381	broad.mit.edu	37	chr1	156237348	156237348	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaggaaagcatatccactctCatactcctcctcatcctcac	4	16	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156237348C>G	uc001foc.3	-	10	1179	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q	SMG5_uc009wrv.2_5'Flank	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	344					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TATCCACTCTCATACTCCTCC	0.527													0	0	0	0.010729	0	9	91										G	156237348	C	G	156237348	3	3	62	1	0	0	0	0	1	0	0	0	14796	835	29	1	2072	1	SMG5	1	156237348	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	21401	156237348	93013273	34	17959										
C1orf61	10485	broad.mit.edu	37	chr1	156386657	156386657	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agagctgccctttttacattCtgaaacaaatcatatgctat	5	9	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156386657C>G	uc001fou.1	-	3	93	c.-24_splice	c.e3-1		C1orf61_uc001fov.1_Intron|C1orf61_uc001fow.1_Intron|C1orf61_uc001fox.1_Intron|C1orf61_uc001foy.1_Intron	NM_006365	NP_006356	Q13536	CROC4_HUMAN	transcriptional activator of the c-fos promoter							nucleus				skin(1)	1	Hepatocellular(266;0.158)					TTTTTACATTCTGAAACAAAT	0.388													0	0	0	0.00245	0	13	35										G	156386657	C	G	156386657	5	3	62	1	0	0	0	0	0	0	1	0	2052	927	32	1		1	C1orf61	1	156386657	Splice_Site	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	149309	156386657	92863964	35	17960										
BCAN	63827	broad.mit.edu	37	chr1	156617355	156617355	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tatgctttctccttttctggGgcccaggaggcctgtgcccg	12	13	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156617355G>A	uc001fpp.2	+	4	858	c.522G>A	c.(520-522)GGG>GGA	p.G174G	BCAN_uc001fpo.2_Silent_p.G174G	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	174	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTTTTCTGGGGCCCAGGAGG	0.642													0	0	0	0.004007	0	13	35										A	156617355	G	A	156617355	2	1	62	1	0	0	0	0	0	0	0	1	1345	1219	43	2		2	BCAN	1	156617355	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	230698	156617355	92633266	36	17961										
NES	10763	broad.mit.edu	37	chr1	156640696	156640696	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccgggcctggctcagctcccGcagcagactcacccatggca	11	18	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156640696G>A	uc001fpq.2	-	4	3417	c.3284C>T	c.(3283-3285)GCG>GTG	p.A1095V		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1095	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCAGCTCCCGCAGCAGACTC	0.662													0	0	0	0.00499	0	17	44										A	156640696	G	A	156640696	3	1	62	1	0	0	0	0	1	0	0	0	10337	1087	38	2	1585	2	NES	1	156640696	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	23341	156640696	92609925	37	17962										
OR6K6	128371	broad.mit.edu	37	chr1	158724899	158724899	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtgtcctctccttcctggaGatctgctataccacaaccac	6	15	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:158724899G>A	uc001fsw.1	+	1	294	c.294G>A	c.(292-294)GAG>GAA	p.E98E		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	98	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					CCTTCCTGGAGATCTGCTATA	0.483													0	0	0	0.01441	0	58	177										A	158724899	G	A	158724899	2	1	62	1	0	0	0	0	0	0	0	1	11204	933	33	1		1	OR6K6	1	158724899	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2084203	158724899	90525722	38	17963										
ATP1A2	477	broad.mit.edu	37	chr1	160098495	160098495	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cggaagaactgcctggtgaaGaacctggaggcggtggagac	17	8	0	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:160098495G>A	uc001fvc.2	+	9	1203	c.1071G>A	c.(1069-1071)AAG>AAA	p.K357K	ATP1A2_uc001fvb.2_Silent_p.K357K|ATP1A2_uc010piz.1_Silent_p.K202K|ATP1A2_uc001fvd.2_Silent_p.K93K|ATP1A2_uc009wtg.1_Silent_p.K45K	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	357	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCTGGTGAAGAACCTGGAGG	0.592													0	0	0	0.003755	0	29	97										A	160098495	G	A	160098495	2	1	62	1	0	0	0	0	0	0	0	1	1129	933	33	1		1	ATP1A2	1	160098495	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1373596	160098495	89152126	39	17964										
RXRG	6258	broad.mit.edu	37	chr1	165370572	165370572	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggggtgtccccgatgagcttGaagaagaagaggtgctccag	16	8	0	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:165370572G>C	uc001gda.2	-	10	1620	c.1320C>G	c.(1318-1320)TTC>TTG	p.F440L		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	440	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CGATGAGCTTGAAGAAGAAGA	0.597													0	0	0	0.01441	0	49	98										C	165370572	G	C	165370572	3	2	62	1	0	0	0	0	1	0	0	0	13765	1281	45	1	75	1	RXRG	1	165370572	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	5272077	165370572	83880049	40	17965										
DPT	1805	broad.mit.edu	37	chr1	168665804	168665804	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatctaaacatttgcaaattCacagtcgtattcagtcatcc	4	10	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:168665804C>T	uc001gfp.2	-	4	605	c.589G>A	c.(589-591)GAA>AAA	p.E197K		NM_001937	NP_001928	Q07507	DERM_HUMAN	dermatopontin precursor	197					cell adhesion	extracellular space|proteinaceous extracellular matrix				ovary(1)	1	all_hematologic(923;0.208)					TTTGCAAATTCACAGTCGTAT	0.473													0	0	0	0.008291	0	9	61										T	168665804	C	T	168665804	3	4	62	1	0	0	0	0	1	0	0	0	4739	835	29	1	20	1	DPT	1	168665804	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3295232	168665804	80584817	41	17966										
KIFAP3	22920	broad.mit.edu	37	chr1	169930298	169930298	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcatccatctgacgactctCtaccatctccagccactgag	5	17	4	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:169930298C>G	uc001ggv.2	-	18	2333	c.2062G>C	c.(2062-2064)GAG>CAG	p.E688Q	KIFAP3_uc010plx.1_Missense_Mutation_p.E390Q	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	688					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGACGACTCTCTACCATCTCC	0.408													0	0	0	0.01441	0	63	83										G	169930298	C	G	169930298	3	3	62	1	0	0	0	0	1	0	0	0	8311	922	32	1	328	1	KIFAP3	1	169930298	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1264494	169930298	79320323	42	17967										
PRRX1	5396	broad.mit.edu	37	chr1	170633362	170633362	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggatcggtgggggagaccatGacctccagctacgggcacgt	16	11	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:170633362G>A	uc001ghf.2	+	1	50	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PRRX1_uc001ghe.2_Missense_Mutation_p.M1I	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	1						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGGAGACCATGACCTCCAGCT	0.657													0	0	0	0.009096	0	4	13										A	170633362	G	A	170633362	3	1	62	1	0	0	0	0	1	0	0	0	12612	1290	45	1	5	1	PRRX1	1	170633362	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	703064	170633362	78617259	43	17968										
LHX4	89884	broad.mit.edu	37	chr1	180241097	180241097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caagcaggagaaggagagctCtgcagaggactgtggggtta	17	6	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:180241097C>G	uc001goe.1	+	5	957	c.734C>G	c.(733-735)TCT>TGT	p.S245C	uc001gof.1_RNA	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AAGGAGAGCTCTGCAGAGGAC	0.617													0	0	0	0.001984	0	5	44										G	180241097	C	G	180241097	3	3	62	1	0	0	0	0	1	0	0	0	8773	913	32	1	752	1	LHX4	1	180241097	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	9607735	180241097	69009524	44	17969										
FAM5C	339479	broad.mit.edu	37	chr1	190195374	190195374	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcagataaactctccctctgAattgcaagcaatgtagctca	7	11	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:190195374A>T	uc001gse.1	-	6	1031	c.799T>A	c.(799-801)TCA>ACA	p.S267T	FAM5C_uc010pot.1_Missense_Mutation_p.S165T	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	267						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TCTCCCTCTGAATTGCAAGCA	0.438													0	0	0	0.00333	0	19	60										T	190195374	A	T	190195374	3	4	62	1	0	0	0	0	1	0	0	0	5594	246	9	5	1513	5	FAM5C	1	190195374	Missense_Mutation	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	9954277	190195374	59055247	45	17970										
ADIPOR1	51094	broad.mit.edu	37	chr1	202920093	202920093	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gattacccgtttgcccttctCttctagcaggggtcccagtt	9	13	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:202920093C>G	uc001gyq.3	-	2	373	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	ADIPOR1_uc010pqd.1_5'Flank|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Missense_Mutation_p.E36Q	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	36	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			TTGCCCTTCTCTTCTAGCAGG	0.527													0	0	0	0.006122	0	16	148										G	202920093	C	G	202920093	3	3	62	1	0	0	0	0	1	0	0	0	318	922	32	1	1049	1	ADIPOR1	1	202920093	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	12724719	202920093	46330528	46	17971										
CHIT1	1118	broad.mit.edu	37	chr1	203192738	203192738	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgcgcagaaacctgatggccGagttgacaaaggtctgacgg	14	9	1	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:203192738G>C	uc001gzn.2	-	5	461	c.365C>G	c.(364-366)TCG>TGG	p.S122W	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.S113W	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	122					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						CCTGATGGCCGAGTTGACAAA	0.577													0	0	0	0.005443	0	22	180										C	203192738	G	C	203192738	3	2	62	1	0	0	0	0	1	0	0	0	3346	1059	37	1	1063	1	CHIT1	1	203192738	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	272645	203192738	46057883	47	17972										
ATP2B4	493	broad.mit.edu	37	chr1	203680026	203680026	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtaatcgaatcctggaccgGaaaggggaagcagtgccatt	13	8	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:203680026G>A	uc001gzw.2	+	12	2705	c.1821G>A	c.(1819-1821)CGG>CGA	p.R607R	ATP2B4_uc001gzv.2_Silent_p.R607R|ATP2B4_uc009xaq.2_Silent_p.R607R	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	607	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCCTGGACCGGAAAGGGGAAG	0.502													0	0	0	0.003163	0	15	24										A	203680026	G	A	203680026	2	1	62	1	0	0	0	0	0	0	0	1	1142	1161	41	1		1	ATP2B4	1	203680026	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	487288	203680026	45570595	48	17973										
REN	5972	broad.mit.edu	37	chr1	204135397	204135397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagcagcagcagtccccagcGaggcatccttctccatccat	8	17	1	0	rs115181548	by1000genomes	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:204135397G>A	uc001haq.2	-	1	69	c.25C>T	c.(25-27)CGC>TGC	p.R9C		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	9					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGTCCCCAGCGAGGCATCCTT	0.557													0	0	0	0.003163	0	13	78										A	204135397	G	A	204135397	3	1	62	1	0	0	0	0	1	0	0	0	13224	1058	37	1	1235	1	REN	1	204135397	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	455371	204135397	45115224	49	17974										
SLC26A9	115019	broad.mit.edu	37	chr1	205896660	205896660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	catccacagccagagtgacaGaaagcgcacagcaaatgaca	9	12	0	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:205896660G>C	uc001hdq.2	-	10	1289	c.1175C>G	c.(1174-1176)TCT>TGT	p.S392C	SLC26A9_uc001hdo.2_Missense_Mutation_p.S60C|SLC26A9_uc001hdp.2_Missense_Mutation_p.S392C	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	392	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CAGAGTGACAGAAAGCGCACA	0.517													0	0	0	0.010729	0	11	45										C	205896660	G	C	205896660	3	2	62	1	0	0	0	0	1	0	0	0	14524	942	33	1	1544	1	SLC26A9	1	205896660	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1761263	205896660	43353961	50	17975										
C1orf107	27042	broad.mit.edu	37	chr1	210014333	210014333	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gagagattttgactttctgtCttctatcgagcttctcatca	7	9	5	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:210014333C>G	uc001hhr.1	+	8	1494	c.1418C>G	c.(1417-1419)TCT>TGT	p.S473C	C1orf107_uc009xcu.1_Missense_Mutation_p.S188C	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	473					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GACTTTCTGTCTTCTATCGAG	0.483													0	0	0	0.004656	0	24	96										G	210014333	C	G	210014333	3	3	62	1	0	0	0	0	1	0	0	0	1981	913	32	1	1448	1	C1orf107	1	210014333	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4117673	210014333	39236288	51	17976										
INTS7	25896	broad.mit.edu	37	chr1	212190334	212190334	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atgatgagcattcttcctctCaggaattattgatgccagac	8	9	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:212190334C>T	uc001hiw.1	-	4	508	c.403G>A	c.(403-405)GAG>AAG	p.E135K	INTS7_uc009xdb.1_Missense_Mutation_p.E135K|INTS7_uc001hix.1_Missense_Mutation_p.E11K|INTS7_uc001hiy.1_Missense_Mutation_p.E135K|INTS7_uc010pta.1_Missense_Mutation_p.E86K	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	135					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TTCTTCCTCTCAGGAATTATT	0.398													0	0	0	0.013114	0	32	123										T	212190334	C	T	212190334	3	4	62	1	0	0	0	0	1	0	0	0	7783	835	29	1	2553	1	INTS7	1	212190334	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2176001	212190334	37060287	52	17977										
CENPF	1063	broad.mit.edu	37	chr1	214815002	214815002	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctagagttggagacagtgcaGcaagctctgagatctgagat	13	7	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:214815002G>A	uc001hkm.2	+	12	3495	c.3321G>A	c.(3319-3321)CAG>CAA	p.Q1107Q		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1107	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGACAGTGCAGCAAGCTCTGA	0.373													0	0	0	0.000602	0	3	115										A	214815002	G	A	214815002	2	1	62	1	0	0	0	0	0	0	0	1	3231	962	34	2		2	CENPF	1	214815002	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2624668	214815002	34435619	53	17978										
TP53BP2	7159	broad.mit.edu	37	chr1	223983678	223983678	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agcctctggatttggttcttCtgggttattctggagatttg	12	6	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:223983678C>T	uc010pvb.1	-	13	2855	c.2563G>A	c.(2563-2565)GAA>AAA	p.E855K	TP53BP2_uc001hod.2_Missense_Mutation_p.E726K|TP53BP2_uc010puz.1_Missense_Mutation_p.E88K|TP53BP2_uc010pva.1_Missense_Mutation_p.E494K	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	849	Pro-rich.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		TTTGGTTCTTCTGGGTTATTC	0.547													0	0	0	0.007413	0	15	89										T	223983678	C	T	223983678	3	4	62	1	0	0	0	0	1	0	0	0	16381	922	32	1	865	1	TP53BP2	1	223983678	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	9168676	223983678	25266943	54	17979										
RYR2	6262	broad.mit.edu	37	chr1	237806646	237806646	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttgattcatgccgggaaggGagaagccatcagaattaggt	14	6	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:237806646G>C	uc001hyl.1	+	48	7361	c.7241G>C	c.(7240-7242)GGA>GCA	p.G2414A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2414	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCGGGAAGGGAGAAGCCATC	0.413													0	0	0	0.01441	0	37	139										C	237806646	G	C	237806646	3	2	62	1	0	0	0	0	1	0	0	0	13769	1174	41	1	7431	1	RYR2	1	237806646	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	13822968	237806646	11443975	55	17980										
OR2L13	284521	broad.mit.edu	37	chr1	248263467	248263467	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctatcttcggcccaggaatCtccgctcaccagctgaagac	8	16	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:248263467C>T	uc001ids.2	+	3	1127	c.790C>T	c.(790-792)CTC>TTC	p.L264F		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GCCCAGGAATCTCCGCTCACC	0.468													0	0	0	0.011902	0	37	88										T	248263467	C	T	248263467	3	4	62	1	0	0	0	0	1	0	0	0	11006	913	32	1	792	1	OR2L13	1	248263467	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10456821	248263467	987154	56	17981										
ZNF672	79894	broad.mit.edu	37	chr1	249142668	249142668	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacggccagcggagtgcgcaGagtgcggcaagtgcttcagc	16	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:249142668G>C	uc001iex.2	+	4	1890	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	399	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGAGTGCGCAGAGTGCGGCAA	0.682													0	0	0	0.001168	0	6	10										C	249142668	G	C	249142668	3	2	62	1	0	0	0	0	1	0	0	0	18076	943	33	1	1197	1	ZNF672	1	249142668	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	879201	249142668	107953	57	17982										
MYT1L	23040	broad.mit.edu	37	chr2	1914104	1914104	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtttctctgctgcagcgatCgggcatccggagaggctgca	14	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:1914104C>G	uc002qxe.2	-	13	2552	c.1725G>C	c.(1723-1725)CCG>CCC	p.P575P	MYT1L_uc002qxd.2_Silent_p.P573P|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	575	C2HC-type 3.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGCAGCGATCGGGCATCCGG	0.587													0	0	0	0.00333	0	22	51										G	1914104	C	G	1914104	2	3	62	1	0	0	0	0	0	0	0	1	10107	871	31	1		1	MYT1L	2	1914104	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		1914104	241285269	58	17983										
TAF1B	9014	broad.mit.edu	37	chr2	10008450	10008450	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagactgggctagtgagcctGagctgctaagtgatgtcagc	14	9	1	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:10008450G>A	uc002qzz.2	+	6	545	c.445G>A	c.(445-447)GAG>AAG	p.E149K	TAF1B_uc010exc.2_Missense_Mutation_p.E149K|TAF1B_uc002qzy.3_Missense_Mutation_p.E149K|TAF1B_uc010yja.1_5'UTR|TAF1B_uc010exd.2_5'UTR	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	149					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TAGTGAGCCTGAGCTGCTAAG	0.398													0	0	0	0.005443	0	19	48										A	10008450	G	A	10008450	3	1	62	1	0	0	0	0	1	0	0	0	15517	1291	45	1	467	1	TAF1B	2	10008450	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	8094346	10008450	233190923	59	17984										
GREB1	9687	broad.mit.edu	37	chr2	11728988	11728988	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggcatacgagcagtacggcGcctctgccatccagcccatc	11	16	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:11728988G>A	uc002rbk.1	+	10	1576	c.1276G>A	c.(1276-1278)GCC>ACC	p.A426T	GREB1_uc002rbn.1_Missense_Mutation_p.A426T|GREB1_uc002rbo.1_Missense_Mutation_p.A60T	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	426						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCAGTACGGCGCCTCTGCCAT	0.597													0	0	0	0.01441	0	57	111										A	11728988	G	A	11728988	3	1	62	1	0	0	0	0	1	0	0	0	6760	1087	38	2	1385	2	GREB1	2	11728988	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1720538	11728988	231470385	60	17985										
KIF3C	3797	broad.mit.edu	37	chr2	26204353	26204353	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttcctggtagatctccaaaTaggaggcccggaccaggtac	11	12	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:26204353T>C	uc002rgu.2	-	1	1091	c.434A>G	c.(433-435)TAT>TGT	p.Y145C	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.Y145C	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	145	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATCTCCAAATAGGAGGCCCG	0.582													0	0	0	0.004289	0	31	71										C	26204353	T	C	26204353	3	2	62	1	0	0	0	0	1	0	0	0	8302	1406	49	5	1979	5	KIF3C	2	26204353	Missense_Mutation	SNP	T	TCGA-DK-A3IT-01A-31D-A20D-08	14475365	26204353	216995020	61	17986										
KIF3C	3797	broad.mit.edu	37	chr2	26204403	26204403	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgggagcgggagatgtgggtGaagatgtgctcaaaggcatt	18	4	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:26204403G>T	uc002rgu.2	-	1	1041	c.384C>A	c.(382-384)TTC>TTA	p.F128L	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.F128L	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	128	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGATGTGGGTGAAGATGTGCT	0.602													1	0	4.75821e-42	0.01441	5.58157e-42	44	91										T	26204403	G	T	26204403	3	4	62	1	0	0	0	0	1	0	0	0	8302	1281	45	3	2029	3	KIF3C	2	26204403	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	50	26204403	216994970	62	17987										
NLRC4	58484	broad.mit.edu	37	chr2	32461380	32461380	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tctgataaatcaagaatgctCagtttgaccaaattgtgaag	8	6	3	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:32461380C>A	uc002roi.2	-	7	2796	c.2550G>T	c.(2548-2550)CTG>CTT	p.L850L	NLRC4_uc002roj.1_Silent_p.L850L|NLRC4_uc010ezt.1_Silent_p.L185L	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	850	LRR 9.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAAGAATGCTCAGTTTGACCA	0.303													1	0	7.87624e-14	0.00278	8.5829e-14	20	40										A	32461380	C	A	32461380	2	1	62	1	0	0	0	0	0	0	0	1	10469	813	29	3		3	NLRC4	2	32461380	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6256977	32461380	210737993	63	17988										
PLEKHH2	130271	broad.mit.edu	37	chr2	43919692	43919692	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aattaaaagcagctaatattCaaaccagtgaatcagagaca	6	7	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:43919692C>T	uc010yny.1	+	4	309	c.226C>T	c.(226-228)CAA>TAA	p.Q76*	PLEKHH2_uc002rte.3_Nonsense_Mutation_p.Q76*|PLEKHH2_uc002rtf.3_Nonsense_Mutation_p.Q76*	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	76	Potential.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCTAATATTCAAACCAGTGA	0.308													0	0	0	0.012319	0	18	109										T	43919692	C	T	43919692	4	4	62	1	0	0	0	0	0	1	0	0	12077	827	29	1	236	1	PLEKHH2	2	43919692	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	11458312	43919692	199279681	64	17989										
SRBD1	55133	broad.mit.edu	37	chr2	45801777	45801777	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gatactcacaagttccgaatGaagtcaagcgtgtctttgtc	9	9	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:45801777G>A	uc002rus.2	-	8	1234	c.1158C>T	c.(1156-1158)TTC>TTT	p.F386F		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	386					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGTTCCGAATGAAGTCAAGCG	0.388													0	0	0	0.01441	0	40	82										A	45801777	G	A	45801777	2	1	62	1	0	0	0	0	0	0	0	1	15132	1281	45	1		1	SRBD1	2	45801777	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1882085	45801777	197397596	65	17990										
PSME4	23198	broad.mit.edu	37	chr2	54122166	54122166	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgtcatatcctccctgcttCtgccaagcttaggctgctct	7	15	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:54122166C>T	uc002rxp.2	-	34	3946	c.3890G>A	c.(3889-3891)AGA>AAA	p.R1297K	PSME4_uc010yop.1_Missense_Mutation_p.R1183K|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.R672K|PSME4_uc010fbv.1_Missense_Mutation_p.R441K	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1297					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CTCCCTGCTTCTGCCAAGCTT	0.388													0	0	0	0.01441	0	45	127										T	54122166	C	T	54122166	3	4	62	1	0	0	0	0	1	0	0	0	12709	913	32	1	1693	1	PSME4	2	54122166	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	8320389	54122166	189077207	66	17991										
CCDC88A	55704	broad.mit.edu	37	chr2	55615938	55615938	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	taataaaattttatctgtctCaccaaaatggatagattgtg	6	5	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:55615938C>T	uc002ryv.2	-	3	1091	c.249G>A	c.(247-249)GTG>GTA	p.V83V	CCDC88A_uc010yoz.1_Silent_p.V83V|CCDC88A_uc010ypa.1_Silent_p.V83V	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	83					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTATCTGTCTCACCAAAATGG	0.264													0	0	0	0.003271	0	30	70										T	55615938	C	T	55615938	2	4	62	1	0	0	0	0	0	0	0	1	2863	813	29	1		1	CCDC88A	2	55615938	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1493772	55615938	187583435	67	17992										
UGP2	7360	broad.mit.edu	37	chr2	64083559	64083559	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcaccacagcatcatcacatGaatttgaggtaaggaggttt	9	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:64083559G>C	uc002scm.2	+	2	445	c.139G>C	c.(139-141)GAA>CAA	p.E47Q	UGP2_uc002scl.2_Missense_Mutation_p.E36Q|UGP2_uc010ypx.1_Missense_Mutation_p.E56Q	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	47					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						ATCATCACATGAATTTGAGGT	0.458													0	0	0	0.013114	0	34	217										C	64083559	G	C	64083559	3	2	62	1	0	0	0	0	1	0	0	0	16940	1291	45	1	145	1	UGP2	2	64083559	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	8467621	64083559	179115814	68	17993										
MEIS1	4211	broad.mit.edu	37	chr2	66795861	66795861	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaggtttcgtaatggacggtCagcaacatatgggaattaga	13	5	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:66795861C>T	uc002sdu.2	+	11	1544	c.1087C>T	c.(1087-1089)CAG>TAG	p.Q363*	MEIS1_uc002sdt.2_Nonsense_Mutation_p.Q363*|MEIS1_uc002sdv.2_Nonsense_Mutation_p.Q361*|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Nonsense_Mutation_p.Q298*|MEIS1_uc002sdw.1_Nonsense_Mutation_p.Q219*	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	363	Required for transcriptional activation (By similarity).						sequence-specific DNA binding transcription factor activity				0						AATGGACGGTCAGCAACATAT	0.408													0	0	0	0.01441	0	98	255										T	66795861	C	T	66795861	4	4	62	1	0	0	0	0	0	1	0	0	9467	827	29	1	1129	1	MEIS1	2	66795861	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2712302	66795861	176403512	69	17994										
ASPRV1	151516	broad.mit.edu	37	chr2	70188237	70188237	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcttccccttgagatagtagCccttacccatgctgttggca	8	13	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188237C>T	uc002sfz.3	-	1	1161	c.584G>A	c.(583-585)GGC>GAC	p.G195D		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	195	Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						GAGATAGTAGCCCTTACCCAT	0.602													0	0	0	0.003755	0	26	48										T	70188237	C	T	70188237	3	4	62	1	0	0	0	0	1	0	0	0	1058	739	26	2	451	2	ASPRV1	2	70188237	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3392376	70188237	173011136	70	17995			1	77		3	3	275	C		8.524583e-06
ASPRV1	151516	broad.mit.edu	37	chr2	70188460	70188460	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttgaggtcattgatgacttCaaagctgtgcagccagaggt	13	7	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188460C>G	uc002sfz.3	-	1	938	c.361G>C	c.(361-363)GAA>CAA	p.E121Q		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	121	Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						TTGATGACTTCAAAGCTGTGC	0.562													0	0	0	0.003163	0	13	54										G	70188460	C	G	70188460	3	3	62	1	0	0	0	0	1	0	0	0	1058	835	29	1	674	1	ASPRV1	2	70188460	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	223	70188460	173010913	71	17996			1	77		3	3	275	C		8.524583e-06
ASPRV1	151516	broad.mit.edu	37	chr2	70188511	70188511	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attggccccatcaaaaggttCcgggacgaaggcatgctgcc	12	12	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188511C>G	uc002sfz.3	-	1	887	c.310G>C	c.(310-312)GAA>CAA	p.E104Q		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	104	Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						TCAAAAGGTTCCGGGACGAAG	0.582													0	0	0	0.003954	0	22	66										G	70188511	C	G	70188511	3	3	62	1	0	0	0	0	1	0	0	0	1058	864	30	1	725	1	ASPRV1	2	70188511	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	51	70188511	173010862	72	17997			1	77		3	3	275	C		8.524583e-06
ATP6V1B1	525	broad.mit.edu	37	chr2	71188791	71188791	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatggaaccatggggaacgtCtgcctcttcctgaacttggc	11	11	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:71188791C>T	uc002shj.2	+	8	840	c.753C>T	c.(751-753)GTC>GTT	p.V251V	ATP6V1B1_uc002shi.1_Silent_p.V251V|ATP6V1B1_uc010fdv.2_Silent_p.V251V|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Silent_p.V209V	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	251					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						TGGGGAACGTCTGCCTCTTCC	0.567													0	0	0	0.007835	0	32	64										T	71188791	C	T	71188791	2	4	62	1	0	0	0	0	0	0	0	1	1178	900	32	1		1	ATP6V1B1	2	71188791	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1000280	71188791	172010582	73	17998										
CAPG	822	broad.mit.edu	37	chr2	85622017	85622017	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcaggaagacgcccaccctCatttccagtccttgaaaaat	8	13	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85622017C>T	uc002spl.1	-	10	1296	c.1046G>A	c.(1045-1047)TGA>TAA	p.*349*	CAPG_uc002spm.1_Silent_p.*334*|CAPG_uc010ysq.1_Silent_p.*349*|CAPG_uc010fgi.1_Silent_p.*349*	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	349					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						CGCCCACCCTCATTTCCAGTC	0.592													0	0	0	0.012319	0	17	48										T	85622017	C	T	85622017	2	4	62	1	0	0	0	0	0	0	0	1	2621	837	29	1		1	CAPG	2	85622017	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	14433226	85622017	157577356	74	17999			2	78	15433506	5	4	3217	N	C	1.84527e-05
CAPG	822	broad.mit.edu	37	chr2	85622055	85622055	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aattgcttgaagatgggactCtcatggccctgaggcagaat	12	8	1	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85622055C>A	uc002spl.1	-	10	1258	c.1008G>T	c.(1006-1008)GAG>GAT	p.E336D	CAPG_uc002spm.1_Missense_Mutation_p.E321D|CAPG_uc010ysq.1_Missense_Mutation_p.E336D|CAPG_uc010fgi.1_Missense_Mutation_p.E336D	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	336					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						AGATGGGACTCTCATGGCCCT	0.597													1	0	0.000132079	0.008871	0.000136528	14	46										A	85622055	C	A	85622055	3	1	62	1	0	0	0	0	1	0	0	0	2621	912	32	3	42	3	CAPG	2	85622055	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	38	85622055	157577318	75	18000			2	78	15433506	5	4	3217	N	C	1.84527e-05
CAPG	822	broad.mit.edu	37	chr2	85625194	85625194	+	Missense_Mutation	SNP	C	C	T													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttgtccagcacaaagcagtCatcagatatcagcagttcaa							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625194C>T	uc002spl.1	-	8	1091	c.841G>A	c.(841-843)GAC>AAC	p.D281N	CAPG_uc002spm.1_Missense_Mutation_p.D266N|CAPG_uc010ysq.1_Missense_Mutation_p.D281N|CAPG_uc010fgi.1_Missense_Mutation_p.D281N|CAPG_uc010fgj.1_Missense_Mutation_p.D175N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	281	Gelsolin-like 3.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						ACAAAGCAGTCATCAGATATC	0.547													0	0	0	0.01441	0	23	129										T	85625194	C	T	85625194	3	4	62	1	0	0	0	0	1	0	0	0	2621	826	29	1	217	1	CAPG	2	85625194	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3139	85625194	157574179	76	18001	88	2	2	78	15433506	5	4	3217	N	C	1.84527e-05
CAPG	822	broad.mit.edu	37	chr2	85625197	85625197	+	Missense_Mutation	SNP	C	C	T													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtccagcacaaagcagtcatCagatatcagcagttcaaggg							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625197C>T	uc002spl.1	-	8	1088	c.838G>A	c.(838-840)GAT>AAT	p.D280N	CAPG_uc002spm.1_Missense_Mutation_p.D265N|CAPG_uc010ysq.1_Missense_Mutation_p.D280N|CAPG_uc010fgi.1_Missense_Mutation_p.D280N|CAPG_uc010fgj.1_Missense_Mutation_p.D174N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	280	Gelsolin-like 3.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						AAGCAGTCATCAGATATCAGC	0.547													0	0	0	0.01441	0	19	133										T	85625197	C	T	85625197	3	4	62	1	0	0	0	0	1	0	0	0	2621	826	29	1	220	1	CAPG	2	85625197	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3	85625197	157574176	77	18002	88	2	2	78	15433506	5	4	3217	N	C	1.84527e-05
CAPG	822	broad.mit.edu	37	chr2	85625233	85625233	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aagggcaaatgggctggagtCagccaccttggtcaggttca	14	9	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625233C>T	uc002spl.1	-	8	1052	c.802G>A	c.(802-804)GAC>AAC	p.D268N	CAPG_uc002spm.1_Missense_Mutation_p.D253N|CAPG_uc010ysq.1_Missense_Mutation_p.D268N|CAPG_uc010fgi.1_Missense_Mutation_p.D268N|CAPG_uc010fgj.1_Missense_Mutation_p.D162N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	268	Gelsolin-like 3.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						GGGCTGGAGTCAGCCACCTTG	0.567													0	0	0	0.01441	0	22	101										T	85625233	C	T	85625233	3	4	62	1	0	0	0	0	1	0	0	0	2621	826	29	1	256	1	CAPG	2	85625233	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	36	85625233	157574140	78	18003			2	78	15433506	5	4	3217	N	C	1.84527e-05
CD8A	925	broad.mit.edu	37	chr2	87017470	87017470	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctggcaggaagaccggcacGaagtggctgaagtacatgat	14	9	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:87017470G>T	uc002srt.2	-	2	1273	c.384C>A	c.(382-384)TTC>TTA	p.F128L	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.F128L|CD8A_uc010ytn.1_Missense_Mutation_p.F169L|CD8A_uc002sru.2_Missense_Mutation_p.F128L	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	128	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						AGACCGGCACGAAGTGGCTGA	0.627													1	0	3.99451e-17	0.009535	4.46986e-17	26	59										T	87017470	G	T	87017470	3	4	62	1	0	0	0	0	1	0	0	0	3044	1049	37	3	343	3	CD8A	2	87017470	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1392237	87017470	156181903	79	18004										
TMEM131	23505	broad.mit.edu	37	chr2	98409038	98409038	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggggcgggagacagcctttCaggctgcggctcctggggct	19	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:98409038C>T	uc002syh.3	-	31	4184	c.3955G>A	c.(3955-3957)GAA>AAA	p.E1319K		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1319	Pro-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						GACAGCCTTTCAGGCTGCGGC	0.677													0	0	0	0.00308	0	7	20										T	98409038	C	T	98409038	3	4	62	1	0	0	0	0	1	0	0	0	16041	835	29	1	1740	1	TMEM131	2	98409038	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	11391568	98409038	144790335	80	18005										
EIF5B	9669	broad.mit.edu	37	chr2	100006265	100006265	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agaaaaagaatacaaaagatGaatttgaggagcgagcaaag	11	3	0	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100006265G>A	uc002tab.2	+	15	2540	c.2356G>A	c.(2356-2358)GAA>AAA	p.E786K		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	786					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TACAAAAGATGAATTTGAGGA	0.353													0	0	0	0.006999	0	31	53										A	100006265	G	A	100006265	3	1	62	1	0	0	0	0	1	0	0	0	5044	1291	45	1	2414	1	EIF5B	2	100006265	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1597227	100006265	143193108	81	18006			3	79	14381032	3	3	806	G		7.336505e-05
EIF5B	9669	broad.mit.edu	37	chr2	100006708	100006708	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatgctgctttgttttatgaGaataaagatccccgcacttt	7	8	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100006708G>C	uc002tab.2	+	16	2614	c.2430G>C	c.(2428-2430)GAG>GAC	p.E810D		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	810					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TGTTTTATGAGAATAAAGATC	0.428													0	0	0	0.01441	0	70	178										C	100006708	G	C	100006708	3	2	62	1	0	0	0	0	1	0	0	0	5044	933	33	1	2492	1	EIF5B	2	100006708	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	443	100006708	143192665	82	18007			3	79	14381032	3	3	806	G		7.336505e-05
EIF5B	9669	broad.mit.edu	37	chr2	100007070	100007070	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgatcaatgggcgtttgaagGaaggagatacaatcattgtt	12	4	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100007070G>C	uc002tab.2	+	17	2834	c.2650G>C	c.(2650-2652)GAA>CAA	p.E884Q		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	884					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						GCGTTTGAAGGAAGGAGATAC	0.448													0	0	0	0.007835	0	33	105										C	100007070	G	C	100007070	3	2	62	1	0	0	0	0	1	0	0	0	5044	1175	41	1	2716	1	EIF5B	2	100007070	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	362	100007070	143192303	83	18008			3	79	14381032	3	3	806	G		7.336505e-05
SLC9A2	6549	broad.mit.edu	37	chr2	103322367	103322367	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acgaagcttccagaaaagctAcaaaagaggaggactatttc	9	8	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:103322367A>G	uc002tca.2	+	11	2182	c.2040A>G	c.(2038-2040)CTA>CTG	p.L680L		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	680	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						CAGAAAAGCTACAAAAGAGGA	0.303													0	0	0	0.003163	0	13	30										G	103322367	A	G	103322367	2	3	62	1	0	0	0	0	0	0	0	1	14712	378	14	5		5	SLC9A2	2	103322367	Silent	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	3315297	103322367	139877006	84	18009										
ST6GAL2	84620	broad.mit.edu	37	chr2	107446552	107446552	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agaagatggtgggtttggttGaatcttctctttagtgttct	12	4	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:107446552G>T	uc002tdq.2	-	5	1407	c.1288C>A	c.(1288-1290)CAA>AAA	p.Q430K	ST6GAL2_uc002tdr.2_Missense_Mutation_p.Q430K|ST6GAL2_uc002tds.3_Missense_Mutation_p.Q430K	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	430	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GGGTTTGGTTGAATCTTCTCT	0.368													1	0	5.44703e-19	0.009718	6.17824e-19	40	126										T	107446552	G	T	107446552	3	4	62	1	0	0	0	0	1	0	0	0	15221	1299	45	3	396	3	ST6GAL2	2	107446552	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4124185	107446552	135752821	85	18010										
RANBP2	5903	broad.mit.edu	37	chr2	109382668	109382668	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	accaaagaaggattttccatCcctgtgtctgctgatggatt	9	9	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:109382668C>A	uc002tem.3	+	20	5799	c.5673C>A	c.(5671-5673)ATC>ATA	p.I1891I		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1891					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GATTTTCCATCCCTGTGTCTG	0.378													1	0	2.27525e-19	0.003954	2.59584e-19	19	125										A	109382668	C	A	109382668	2	1	62	1	0	0	0	0	0	0	0	1	13028	845	30	3		3	RANBP2	2	109382668	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1936116	109382668	133816705	86	18011										
RANBP2	5903	broad.mit.edu	37	chr2	109383783	109383783	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcttttccgttttggtgagtCaacaacaggatttaacttca	7	8	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:109383783C>G	uc002tem.3	+	20	6914	c.6788C>G	c.(6787-6789)TCA>TGA	p.S2263*		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2263					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTTGGTGAGTCAACAACAGGA	0.418													0	0	0	0.01441	0	50	297										G	109383783	C	G	109383783	4	3	62	1	0	0	0	0	0	1	0	0	13028	838	29	1	6866	1	RANBP2	2	109383783	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1115	109383783	133815590	87	18012										
CLASP1	23332	broad.mit.edu	37	chr2	122182786	122182786	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaatcttgcttcgcttttctGaagacggtgtcacaggtggg	13	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:122182786G>A	uc002tnc.2	-	22	2531	c.2141C>T	c.(2140-2142)TCA>TTA	p.S714L	CLASP1_uc002tmz.2_5'UTR|CLASP1_uc002tna.2_5'UTR|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.S722L|CLASP1_uc010yza.1_Missense_Mutation_p.S714L|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.S721L	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	714	Ser-rich.|Interaction with microtubules, MAPRE1 and MAPRE3.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TCGCTTTTCTGAAGACGGTGT	0.512													0	0	0	0.003271	0	31	68										A	122182786	G	A	122182786	3	1	62	1	0	0	0	0	1	0	0	0	3454	1294	45	1	2575	1	CLASP1	2	122182786	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	12799003	122182786	121016587	88	18013										
CSRNP3	80034	broad.mit.edu	37	chr2	166514277	166514277	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tctttctctttcagcttcctCcattctcaaaagggagaaac	5	12	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:166514277C>G	uc002udf.2	+	5	531	c.155C>G	c.(154-156)TCC>TGC	p.S52C	CSRNP3_uc002udg.2_Missense_Mutation_p.S52C	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	52	Ser-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TCAGCTTCCTCCATTCTCAAA	0.443													0	0	0	0.00874	0	31	85										G	166514277	C	G	166514277	3	3	62	1	0	0	0	0	1	0	0	0	3965	855	30	1	161	1	CSRNP3	2	166514277	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	44331491	166514277	76685096	89	18014										
LASS6	253782	broad.mit.edu	37	chr2	169313067	169313067	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccaccttcccgcaggctgagGacctctatctcgcttttccc	7	18	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:169313067G>T	uc002ueb.1	+	1	233	c.109G>T	c.(109-111)GAC>TAC	p.D37Y	LASS6_uc002uec.1_Missense_Mutation_p.D37Y	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	37	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						GCAGGCTGAGGACCTCTATCT	0.577													1	0	3.83957e-06	0.00278	4.00442e-06	19	59										T	169313067	G	T	169313067	3	4	62	1	0	0	0	0	1	0	0	0	8643	1174	41	3	111	3	LASS6	2	169313067	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2798790	169313067	73886306	90	18015										
GAD1	2571	broad.mit.edu	37	chr2	171702544	171702544	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaataattccagctgattttGaggcaaaaattcttgaagcc	7	7	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:171702544G>C	uc002ugi.2	+	10	1395	c.973G>C	c.(973-975)GAG>CAG	p.E325Q		NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	325					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGCTGATTTTGAGGCAAAAAT	0.363													0	0	0	0.005443	0	22	105										C	171702544	G	C	171702544	3	2	62	1	0	0	0	0	1	0	0	0	6179	1291	45	1	1048	1	GAD1	2	171702544	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2389477	171702544	71496829	91	18016										
SLC25A12	8604	broad.mit.edu	37	chr2	172691273	172691273	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atctttccttgtgccagctaGagtgctatatatcttacgaa	7	9	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:172691273G>C	uc002uhh.2	-	7	804	c.715C>G	c.(715-717)CTA>GTA	p.L239V	SLC25A12_uc010fqh.2_Missense_Mutation_p.L132V|SLC25A12_uc010zdv.1_RNA	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	239					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	GTGCCAGCTAGAGTGCTATAT	0.373													0	0	0	0.011902	0	34	105										C	172691273	G	C	172691273	3	2	62	1	0	0	0	0	1	0	0	0	14474	933	33	1	1369	1	SLC25A12	2	172691273	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	988729	172691273	70508100	92	18017										
NFE2L2	4780	broad.mit.edu	37	chr2	178097233	178097233	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtttcaggtgactgagcctGattagtagcaatgaagactg	12	6	1	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:178097233G>C	uc002ulh.3	-	4	1036	c.481C>G	c.(481-483)CAG>GAG	p.Q161E	NFE2L2_uc002ulg.3_Missense_Mutation_p.Q145E|NFE2L2_uc010zfa.1_Missense_Mutation_p.Q138E|NFE2L2_uc002uli.3_Missense_Mutation_p.Q145E|NFE2L2_uc010fra.2_3'UTR	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	161					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			GACTGAGCCTGATTAGTAGCA	0.448			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.006214	0	9	56										C	178097233	G	C	178097233	3	2	62	1	0	0	0	0	1	0	0	0	10368	1299	45	1	1344	1	NFE2L2	2	178097233	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	5405960	178097233	65102140	93	18018										
ITGA4	3676	broad.mit.edu	37	chr2	182363467	182363467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aagcatacaggtgtccagcaGagaagctaactgtagaacac	10	9	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:182363467G>C	uc002unu.2	+	15	2421	c.1658G>C	c.(1657-1659)AGA>ACA	p.R553T	ITGA4_uc010frj.1_Missense_Mutation_p.R35T	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	553	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GTGTCCAGCAGAGAAGCTAAC	0.383													0	0	0	0.00278	0	18	79										C	182363467	G	C	182363467	3	2	62	1	0	0	0	0	1	0	0	0	7878	942	33	1	1716	1	ITGA4	2	182363467	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4266234	182363467	60835906	94	18019										
MSTN	2660	broad.mit.edu	37	chr2	190924966	190924966	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcatgtcaagtttcagagatCggattccagtataccttgta	8	8	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190924966C>T	uc002urp.2	-	2	702	c.569G>A	c.(568-570)CGA>CAA	p.R190Q		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	190					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TTTCAGAGATCGGATTCCAGT	0.428													0	0	0	0.01441	0	43	239										T	190924966	C	T	190924966	3	4	62	1	0	0	0	0	1	0	0	0	9893	884	31	1	566	1	MSTN	2	190924966	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	8561499	190924966	52274407	95	18020			4	80	90917896	4	4	2226	N	G_C	6.177191e-06
MSTN	2660	broad.mit.edu	37	chr2	190925004	190925004	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtaccgtctttcataggtttGatgagtctcaggatttgcac	10	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190925004G>C	uc002urp.2	-	2	664	c.531C>G	c.(529-531)ATC>ATG	p.I177M		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	177					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TCATAGGTTTGATGAGTCTCA	0.413													0	0	0	0.013537	0	11	228										C	190925004	G	C	190925004	3	2	62	1	0	0	0	0	1	0	0	0	9893	1280	45	1	604	1	MSTN	2	190925004	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	38	190925004	52274369	96	18021			4	80	90917896	4	4	2226	N	G_C	6.177191e-06
MSTN	2660	broad.mit.edu	37	chr2	190926953	190926953	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctaataggactacttacactCtgtaggcatggtaatgattg	9	7	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190926953C>G	uc002urp.2	-	1	503	c.370G>C	c.(370-372)GAG>CAG	p.E124Q		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	124					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TACTTACACTCTGTAGGCATG	0.403													0	0	0	0.01441	0	44	218										G	190926953	C	G	190926953	3	3	62	1	0	0	0	0	1	0	0	0	9893	922	32	1	769	1	MSTN	2	190926953	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1949	190926953	52272420	97	18022			4	80	90917896	4	4	2226	N	G_C	6.177191e-06
MSTN	2660	broad.mit.edu	37	chr2	190927191	190927191	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaagatttagtgttttgtctCcaagtacatgcattacacag	8	7	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190927191C>A	uc002urp.2	-	1	265	c.132G>T	c.(130-132)TGG>TGT	p.W44C		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	44					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TGTTTTGTCTCCAAGTACATG	0.378													1	0	5.71845e-15	0.005524	6.3261e-15	29	202										A	190927191	C	A	190927191	3	1	62	1	0	0	0	0	1	0	0	0	9893	856	30	3	1007	3	MSTN	2	190927191	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	238	190927191	52272182	98	18023			4	80	90917896	4	4	2226	N	G_C	6.177191e-06
ATIC	471	broad.mit.edu	37	chr2	216177324	216177324	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggagggactgcaaaagctctCagggatgctggtctggcagt	16	8	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:216177324C>T	uc002vex.3	+	2	297	c.123C>T	c.(121-123)CTC>CTT	p.L41L	ATIC_uc010zjo.1_5'UTR|ATIC_uc002vey.3_Silent_p.L40L	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	41					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CAAAAGCTCTCAGGGATGCTG	0.428			T	ALK	ALCL								0	0	0	0.00333	0	22	38										T	216177324	C	T	216177324	2	4	62	1	0	0	0	0	0	0	0	1	1105	813	29	1		1	ATIC	2	216177324	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	25250133	216177324	27022049	99	18024										
SLC23A3	151295	broad.mit.edu	37	chr2	220033453	220033453	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccctgccacaaccaggctggGagccagcaccaggggcccac	12	18	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220033453G>A	uc010zks.1	-	5	706	c.595C>T	c.(595-597)CCC>TCC	p.P199S	NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Missense_Mutation_p.P207S|SLC23A3_uc010fwb.2_Missense_Mutation_p.P199S|SLC23A3_uc002vjs.1_Missense_Mutation_p.S51F|SLC23A3_uc002vjt.1_Missense_Mutation_p.P57S	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	199	Helical; (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCAGGCTGGGAGCCAGCACC	0.662													0	0	0	0.000602	0	4	15										A	220033453	G	A	220033453	3	1	62	1	0	0	0	0	1	0	0	0	14464	1174	41	1	1269	1	SLC23A3	2	220033453	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3856129	220033453	23165920	100	18025										
SLC23A3	151295	broad.mit.edu	37	chr2	220034633	220034634	+	Nonsense_Mutation	DNP	GG	GG	TA													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agggattctggggagcaggtGgaggcaagggggccagggca							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220034633_220034634GG>TA	uc010zks.1	-	1	184_185	c.73_74CC>TA	c.(73-75)CCA>TAA	p.P25*	NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Nonsense_Mutation_p.P25*|SLC23A3_uc010fwb.2_Nonsense_Mutation_p.P25*|SLC23A3_uc002vjs.1_5'Flank|SLC23A3_uc002vjt.1_5'Flank	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	25	Cytoplasmic (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGAGCAGGTGGAGGCAAGGGG	0.614													0	0	0	0.004672	0	4	35										TA	220034634	GG	TA	220034633	4	4	62	1	0	0	0	0	0	1	0	0	14464	1348	47	4	1830	4	SLC23A3	2	220034633	Nonsense_Mutation	DNP	GG	TCGA-DK-A3IT-01A-31D-A20D-08	1180	220034633	23164740	101	18026										
TRIP12	9320	broad.mit.edu	37	chr2	230636274	230636274	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgaagatgactgagtgggaaGactgattcaaatccatctct	10	7	2	6			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:230636274G>C	uc002vpw.1	-	38	5653	c.5544C>G	c.(5542-5544)GTC>GTG	p.V1848V	TRIP12_uc002vpx.1_Silent_p.V1896V|TRIP12_uc002vpy.1_Silent_p.V1578V	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1848					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGAGTGGGAAGACTGATTCAA	0.378													0	0	0	0.001168	0	5	47										C	230636274	G	C	230636274	2	2	62	1	0	0	0	0	0	0	0	1	16553	929	33	1		1	TRIP12	2	230636274	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10601641	230636274	12563099	102	18027										
INPP5D	3635	broad.mit.edu	37	chr2	234079180	234079180	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagaaaatcaagcagcagcaGtacgcagacctcctgtccca	8	14	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:234079180G>A	uc010zmo.1	+	15	1983	c.1830G>A	c.(1828-1830)CAG>CAA	p.Q610Q	INPP5D_uc010zmp.1_Silent_p.Q609Q	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	610					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGCAGCAGCAGTACGCAGACC	0.532													0	0	0	0.00278	0	18	36										A	234079180	G	A	234079180	2	1	62	1	0	0	0	0	0	0	0	1	7756	1020	36	2		2	INPP5D	2	234079180	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3442906	234079180	9120193	103	18028										
RPUSD3	285367	broad.mit.edu	37	chr3	9885243	9885243	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcgaagggctggtccccgagGggccccgaccgttggcagga	18	13	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:9885243G>C	uc011atk.1	-	2	172	c.168C>G	c.(166-168)CCC>CCG	p.P56P	ARPC4_uc003btc.1_Intron|RPUSD3_uc011atl.1_Silent_p.P56P|RPUSD3_uc011atm.1_Silent_p.P48P|RPUSD3_uc003btn.2_Silent_p.P48P	NM_173659	NP_775930	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	56					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(1)	1	Medulloblastoma(99;0.227)					GGTCCCCGAGGGGCCCCGACC	0.657													0	0	0	0.013537	0	11	23										C	9885243	G	C	9885243	2	2	62	1	0	0	0	0	0	0	0	1	13668	1219	43	4		4	RPUSD3	3	9885243	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		9885243	188137187	104	18029										
EFHB	151651	broad.mit.edu	37	chr3	19925987	19925987	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cacttggtctcagaagtgtcCggagagtcttttctgtgctt	11	9	3	2	rs142916632	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:19925987C>T	uc003cbl.3	-	11	2250	c.2054G>A	c.(2053-2055)CGG>CAG	p.R685Q	EFHB_uc003cbm.2_Missense_Mutation_p.R555Q	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	685				R -> W (in Ref. 1; BAC85491).	signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CAGAAGTGTCCGGAGAGTCTT	0.398													0	0	0	0.004007	0	13	32										T	19925987	C	T	19925987	3	4	62	1	0	0	0	0	1	0	0	0	4945	652	23	2	459	2	EFHB	3	19925987	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10040744	19925987	178096443	105	18030										
NR1D2	9975	broad.mit.edu	37	chr3	24003672	24003672	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcaagaaaacatcaaaagctCttctcctccatcttctgatt	4	12	5	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:24003672C>T	uc003ccs.2	+	5	1041	c.722C>T	c.(721-723)TCT>TTT	p.S241F	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.S166F	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	241					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						ATCAAAAGCTCTTCTCCTCCA	0.448													0	0	0	0.004007	0	14	32										T	24003672	C	T	24003672	3	4	62	1	0	0	0	0	1	0	0	0	10616	913	32	1	740	1	NR1D2	3	24003672	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4077685	24003672	174018758	106	18031										
NR1D2	9975	broad.mit.edu	37	chr3	24003755	24003755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aggatacctttatgtataatCaagagcagcaagaaaactca	7	7	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:24003755C>G	uc003ccs.2	+	5	1124	c.805C>G	c.(805-807)CAA>GAA	p.Q269E	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.Q194E	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	269					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						TATGTATAATCAAGAGCAGCA	0.423													0	0	0	0.00245	0	12	50										G	24003755	C	G	24003755	3	3	62	1	0	0	0	0	1	0	0	0	10616	827	29	1	823	1	NR1D2	3	24003755	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	83	24003755	174018675	107	18032										
DLEC1	9940	broad.mit.edu	37	chr3	38136538	38136538	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccccacacagaccacgagttCatcctgagcttttctcctca	5	17	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38136538C>A	uc003cho.1	+	13	2109	c.2088C>A	c.(2086-2088)TTC>TTA	p.F696L	DLEC1_uc003chp.1_Missense_Mutation_p.F696L|DLEC1_uc010hgv.1_Missense_Mutation_p.F696L|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	696					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		ACCACGAGTTCATCCTGAGCT	0.517													1	0	7.92952e-12	0.003954	8.54512e-12	15	61										A	38136538	C	A	38136538	3	1	62	1	0	0	0	0	1	0	0	0	4552	825	29	3	2138	3	DLEC1	3	38136538	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	14132783	38136538	159885892	108	18033										
DLEC1	9940	broad.mit.edu	37	chr3	38136557	38136557	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcatcctgagcttttctcctCatgaggttcagatggtgtca	9	10	5	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38136557C>T	uc003cho.1	+	13	2128	c.2107C>T	c.(2107-2109)CAT>TAT	p.H703Y	DLEC1_uc003chp.1_Missense_Mutation_p.H703Y|DLEC1_uc010hgv.1_Missense_Mutation_p.H703Y|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	703					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTTTTCTCCTCATGAGGTTCA	0.527													0	0	0	0.008871	0	15	53										T	38136557	C	T	38136557	3	4	62	1	0	0	0	0	1	0	0	0	4552	826	29	1	2157	1	DLEC1	3	38136557	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	19	38136557	159885873	109	18034										
DLEC1	9940	broad.mit.edu	37	chr3	38138129	38138129	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attgtcctggaaatcgaggtGaaaggctcagtagaaccttt	11	7	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38138129G>A	uc003cho.1	+	15	2262	c.2241G>A	c.(2239-2241)GTG>GTA	p.V747V	DLEC1_uc003chp.1_Silent_p.V747V|DLEC1_uc010hgv.1_Silent_p.V747V|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	747					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AAATCGAGGTGAAAGGCTCAG	0.493													0	0	0	0.01441	0	43	77										A	38138129	G	A	38138129	2	1	62	1	0	0	0	0	0	0	0	1	4552	1277	45	1		1	DLEC1	3	38138129	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1572	38138129	159884301	110	18035										
TMEM89	440955	broad.mit.edu	37	chr3	48658340	48658340	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggtggctagatgacgtaggtGgccttcgatgtggaccagga	17	7	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48658340G>T	uc011bbo.1	-	2	415	c.415C>A	c.(415-417)CAC>AAC	p.H139N		NM_001008269	NP_001008270	A2RUT3	TMM89_HUMAN	transmembrane protein 89 precursor	139	Cytoplasmic (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TGACGTAGGTGGCCTTCGATG	0.612													1	0	4.65686e-17	0.003755	5.20106e-17	35	86										T	48658340	G	T	48658340	3	4	62	1	0	0	0	0	1	0	0	0	16210	1348	47	4	67	4	TMEM89	3	48658340	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10520211	48658340	149364090	111	18036										
CELSR3	1951	broad.mit.edu	37	chr3	48675652	48675652	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atcccctcaggagtgaccctCacttctgggaactctggagg	11	13	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48675652C>A	uc003cul.2	-	35	10206	c.9925G>T	c.(9925-9927)GAG>TAG	p.E3309*	CELSR3_uc003cuf.1_Intron|SLC26A6_uc003cuh.2_5'Flank|SLC26A6_uc010hke.2_5'Flank|SLC26A6_uc003cuk.2_5'Flank|SLC26A6_uc003cui.2_5'Flank|SLC26A6_uc003cuj.2_5'Flank|SLC26A6_uc011bbp.1_5'Flank|CELSR3_uc010hkf.2_Nonsense_Mutation_p.E599*|CELSR3_uc010hkg.2_Nonsense_Mutation_p.E1292*	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	3309	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAGTGACCCTCACTTCTGGGA	0.607													1	0	6.00712e-18	0.012213	6.76091e-18	21	55										A	48675652	C	A	48675652	4	1	62	1	0	0	0	0	0	1	0	0	3223	835	29	3	17	3	CELSR3	3	48675652	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	17312	48675652	149346778	112	18037										
CELSR3	1951	broad.mit.edu	37	chr3	48694197	48694197	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cgcgcaggctccgccgttgcGacatgggttggagtagcaga	16	11	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48694197G>C	uc003cul.2	-	2	4614	c.4333C>G	c.(4333-4335)CGC>GGC	p.R1445G	CELSR3_uc003cuf.1_Missense_Mutation_p.R1515G	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1445	Extracellular (Potential).|EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCGCCGTTGCGACATGGGTTG	0.711													0	0	0	0.004672	0	2	8										C	48694197	G	C	48694197	3	2	62	1	0	0	0	0	1	0	0	0	3223	1058	37	1	5741	1	CELSR3	3	48694197	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	18545	48694197	149328233	113	18038										
CELSR3	1951	broad.mit.edu	37	chr3	48698429	48698429	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgcgccacgtagcgcttctCgctgaactgaggagcattgt	12	12	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48698429C>T	uc003cul.2	-	1	1920	c.1639G>A	c.(1639-1641)GAG>AAG	p.E547K	CELSR3_uc003cuf.1_Missense_Mutation_p.E617K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	547	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TAGCGCTTCTCGCTGAACTGA	0.652													0	0	0	0.00333	0	22	34										T	48698429	C	T	48698429	3	4	62	1	0	0	0	0	1	0	0	0	3223	893	31	1	8439	1	CELSR3	3	48698429	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4232	48698429	149324001	114	18039										
QRICH1	54870	broad.mit.edu	37	chr3	49094498	49094498	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggaaagagagagtttgcaaGggtctgcactacctcttcat	11	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49094498G>A	uc010hkq.2	-	4	1431	c.1135C>T	c.(1135-1137)CTT>TTT	p.L379F	QRICH1_uc003cvu.2_Missense_Mutation_p.L379F|QRICH1_uc003cvv.2_Missense_Mutation_p.L379F	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	379	Gln-rich.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAGTTTGCAAGGGTCTGCACT	0.522													0	0	0	0.004656	0	24	55										A	49094498	G	A	49094498	3	1	62	1	0	0	0	0	1	0	0	0	12879	1000	35	2	1227	2	QRICH1	3	49094498	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	396069	49094498	148927932	115	18040										
KLHDC8B	200942	broad.mit.edu	37	chr3	49212384	49212384	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttgtcaacactgtggagatgTttgacctggagcatggtgag	14	6	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49212384T>G	uc003cwh.2	+	4	936	c.751T>G	c.(751-753)TTT>GTT	p.F251V	KLHDC8B_uc003cwi.1_Missense_Mutation_p.F124V	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	251	Kelch 6.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGTGGAGATGTTTGACCTGGA	0.587													0	0	0	0.003163	0	12	82										G	49212384	T	G	49212384	3	3	62	1	0	0	0	0	1	0	0	0	8363	1725	60	5	761	5	KLHDC8B	3	49212384	Missense_Mutation	SNP	T	TCGA-DK-A3IT-01A-31D-A20D-08	117886	49212384	148810046	116	18041										
USP4	7375	broad.mit.edu	37	chr3	49362149	49362149	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acttactttgactgcaaggtCtgcctgggccatgtgccatc	10	12	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362149C>G	uc003cwq.2	-	6	760	c.681G>C	c.(679-681)CAG>CAC	p.Q227H	USP4_uc003cwr.2_Missense_Mutation_p.Q227H	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	227					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ACTGCAAGGTCTGCCTGGGCC	0.438													0	0	0	0.004007	0	13	90										G	49362149	C	G	49362149	3	3	62	1	0	0	0	0	1	0	0	0	17068	912	32	1	2278	1	USP4	3	49362149	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	149765	49362149	148660281	117	18042			5	81		3	3	314	N	C_-	1.11247e-05
USP4	7375	broad.mit.edu	37	chr3	49362440	49362441	+	Frame_Shift_Ins	INS	-	-	A													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcacgctccgcagggatgttINSgaatagcttccgcatctctt							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362440_49362441insA	uc003cwq.2	-	5	598_599	c.519_520insT	c.(517-522)TTCAACfs	p.F173fs	USP4_uc003cwr.2_Frame_Shift_Ins_p.F173fs	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	173_174					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCAGGGATGTTGAATAGCTTCC	0.5																		52	162	---	---								A	49362441	-	A	49362440	7	5	62	1	0	1	1	0	0	0	0	0	17068	1812	63	0	2443	0	USP4	3	49362440	Frame_Shift_Ins	INS	-	TCGA-DK-A3IT-01A-31D-A20D-08	291	49362440	148659990	118	18043			5	81		3	3	314	N	C_-	1.11247e-05
USP4	7375	broad.mit.edu	37	chr3	49362462	49362462	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatagcttccgcatctctttCtcgatggttgctaggaacag	9	10	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362462C>A	uc003cwq.2	-	5	577	c.498G>T	c.(496-498)GAG>GAT	p.E166D	USP4_uc003cwr.2_Missense_Mutation_p.E166D	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	166					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCATCTCTTTCTCGATGGTTG	0.478													1	0	3.73808e-20	0.005443	4.29843e-20	21	131										A	49362462	C	A	49362462	3	1	62	1	0	0	0	0	1	0	0	0	17068	912	32	3	2465	3	USP4	3	49362462	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	22	49362462	148659968	119	18044			5	81		3	3	314	N	C_-	1.11247e-05
DAG1	1605	broad.mit.edu	37	chr3	49568599	49568599	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acaggatgcggagcttctcaGaagtagagcttcacaacatg	11	9	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49568599G>A	uc003cxc.3	+	3	1073	c.655G>A	c.(655-657)GAA>AAA	p.E219K		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	219	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAGCTTCTCAGAAGTAGAGCT	0.488													0	0	0	0.00333	0	20	45										A	49568599	G	A	49568599	3	1	62	1	0	0	0	0	1	0	0	0	4225	943	33	1	661	1	DAG1	3	49568599	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	206137	49568599	148453831	120	18045										
BSN	8927	broad.mit.edu	37	chr3	49691151	49691151	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagccaccacagctgtggctCcttgtccagctgggctgcca	11	16	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49691151C>A	uc003cxe.3	+	5	4276	c.4162C>A	c.(4162-4164)CCT>ACT	p.P1388T		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1388					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCTGTGGCTCCTTGTCCAGC	0.622													1	0	4.3181e-19	0.013726	4.90731e-19	32	62										A	49691151	C	A	49691151	3	1	62	1	0	0	0	0	1	0	0	0	1530	855	30	3	4180	3	BSN	3	49691151	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	122552	49691151	148331279	121	18046										
AMIGO3	386724	broad.mit.edu	37	chr3	49756782	49756782	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttagcaggtcggcagcgcaGatacatttgtaggggcagtt	14	8	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49756782G>C	uc003cxj.2	-	1	457	c.117C>G	c.(115-117)ATC>ATG	p.I39M	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	39	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CGGCAGCGCAGATACATTTGT	0.652											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	17	144										C	49756782	G	C	49756782	3	2	62	1	0	0	0	0	1	0	0	0	577	932	33	1	1401	1	AMIGO3	3	49756782	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	65631	49756782	148265648	122	18047										
GMPPB	29925	broad.mit.edu	37	chr3	49759447	49759447	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caatgcaggactcaagccagGaatgggaacggatccgggca	14	10	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49759447G>A	uc003cxk.1	-	8	1127	c.902C>T	c.(901-903)TCC>TTC	p.S301F	AMIGO3_uc003cxj.2_5'Flank|GMPPB_uc003cxl.1_Missense_Mutation_p.S301F	NM_021971	NP_068806	Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B isoform 2	301					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTCAAGCCAGGAATGGGAACG	0.667													0	0	0	0.006122	0	12	114										A	49759447	G	A	49759447	3	1	62	1	0	0	0	0	1	0	0	0	6495	1174	41	1	265	1	GMPPB	3	49759447	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2665	49759447	148262983	123	18048										
MST1R	4486	broad.mit.edu	37	chr3	49927421	49927421	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggccaggaagtgggtaaggtCaaaagggtcaatgtggcggt	18	5	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49927421C>G	uc003cxy.3	-	19	4147	c.3883G>C	c.(3883-3885)GAC>CAC	p.D1295H	MST1R_uc011bdc.1_Missense_Mutation_p.D174H	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1295	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGGTAAGGTCAAAAGGGTCA	0.532													0	0	0	0.011902	0	35	82										G	49927421	C	G	49927421	3	3	62	1	0	0	0	0	1	0	0	0	9891	826	29	1	327	1	MST1R	3	49927421	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	167974	49927421	148095009	124	18049										
PARP3	10039	broad.mit.edu	37	chr3	51979599	51979599	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggtgccacaccccctggaccGagactaccagcttctcaagt	9	16	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:51979599G>T	uc003dby.2	+	7	1321	c.950G>T	c.(949-951)CGA>CTA	p.R317L	PARP3_uc003dbz.2_Missense_Mutation_p.R324L	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	317	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCCCTGGACCGAGACTACCAG	0.627													1	0	1.59932e-28	0.007835	1.85738e-28	32	61										T	51979599	G	T	51979599	3	4	62	1	0	0	0	0	1	0	0	0	11462	1058	37	3	997	3	PARP3	3	51979599	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2052178	51979599	146042831	125	18050										
FAM116A	201627	broad.mit.edu	37	chr3	57649368	57649368	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtgtatgacaattaccttctGaaagtagcctctttttagag	8	7	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:57649368G>C	uc003dja.2	-	5	579	c.508C>G	c.(508-510)CAG>GAG	p.Q170E		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	170										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		ATTACCTTCTGAAAGTAGCCT	0.289													0	0	0	0.003271	0	25	68										C	57649368	G	C	57649368	3	2	62	1	0	0	0	0	1	0	0	0	5407	1299	45	1	1382	1	FAM116A	3	57649368	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	5669769	57649368	140373062	126	18051										
ADAMTS9	56999	broad.mit.edu	37	chr3	64607917	64607917	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgccatggcccatgactgttCcagtaaaactgctgaggttt	10	10	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:64607917C>A	uc003dmg.2	-	18	2675	c.2643G>T	c.(2641-2643)TGG>TGT	p.W881C	ADAMTS9_uc011bfo.1_Missense_Mutation_p.W853C|ADAMTS9_uc003dmh.1_Missense_Mutation_p.W710C|ADAMTS9_uc003dmk.1_Missense_Mutation_p.W881C	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	881	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CATGACTGTTCCAGTAAAACT	0.393													1	0	1.57945e-13	0.011902	1.71795e-13	35	68										A	64607917	C	A	64607917	3	1	62	1	0	0	0	0	1	0	0	0	273	856	30	3	3252	3	ADAMTS9	3	64607917	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6958549	64607917	133414513	127	18052										
UBA3	9039	broad.mit.edu	37	chr3	69124658	69124658	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtatctaacaagaactggaGagactgtaaagaatggaaag	11	4	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:69124658G>C	uc003dno.2	-	4	207	c.187C>G	c.(187-189)CTC>GTC	p.L63V	UBA3_uc003dnq.2_Missense_Mutation_p.L49V|UBA3_uc011bfy.1_5'UTR|UBA3_uc011bfz.1_Intron	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	63	Interaction with UBE2M N-terminus.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		AAGAACTGGAGAGACTGTAAA	0.338													0	0	0	0.010504	0	16	39										C	69124658	G	C	69124658	3	2	62	1	0	0	0	0	1	0	0	0	16826	942	33	1	1264	1	UBA3	3	69124658	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4516741	69124658	128897772	128	18053										
FRMD4B	23150	broad.mit.edu	37	chr3	69246184	69246184	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caaaggttcttcttgaaactGaaatcctgaaagattaaaga	7	6	2	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:69246184G>C	uc003dnv.2	-	13	1249	c.959C>G	c.(958-960)TCA>TGA	p.S320*	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_5'UTR|FRMD4B_uc011bga.1_Nonsense_Mutation_p.S164*	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	320	FERM.					cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TCTTGAAACTGAAATCCTGAA	0.418													0	0	0	0.00499	0	13	19										C	69246184	G	C	69246184	4	2	62	1	0	0	0	0	0	1	0	0	6052	1294	45	1	2189	1	FRMD4B	3	69246184	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	121526	69246184	128776246	129	18054										
EIF4E3	317649	broad.mit.edu	37	chr3	71743081	71743081	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttgctaacagcaactctttCcaaactgtggactgatatgg	9	9	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:71743081C>G	uc003dov.3	-	5	425	c.417G>C	c.(415-417)TGG>TGC	p.W139C	EIF4E3_uc011bgc.1_Missense_Mutation_p.W33C|EIF4E3_uc003dox.2_Missense_Mutation_p.W33C|EIF4E3_uc011bgd.1_Missense_Mutation_p.W33C|EIF4E3_uc010hoc.2_Missense_Mutation_p.W33C	NM_001134651	NP_001128123	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E	139					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		GCAACTCTTTCCAAACTGTGG	0.448													0	0	0	0.009096	0	3	10										G	71743081	C	G	71743081	3	3	62	1	0	0	0	0	1	0	0	0	5031	856	30	1	269	1	EIF4E3	3	71743081	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2496897	71743081	126279349	130	18055										
OR5H1	26341	broad.mit.edu	37	chr3	97852160	97852160	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttattttctcaggttcaattCaggtattcagcattgtgact	7	7	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:97852160C>G	uc011bgt.1	+	1	619	c.619C>G	c.(619-621)CAG>GAG	p.Q207E		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						AGGTTCAATTCAGGTATTCAG	0.313													0	0	0	0.001984	0	6	33										G	97852160	C	G	97852160	3	3	62	1	0	0	0	0	1	0	0	0	11159	827	29	1	621	1	OR5H1	3	97852160	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	26109079	97852160	100170270	131	18056										
PHLDB2	90102	broad.mit.edu	37	chr3	111686606	111686606	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggaaaaacgattacaggaaGaaactagccagaggcagaag	12	6	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:111686606G>A	uc010hqa.2	+	15	3661	c.3250G>A	c.(3250-3252)GAA>AAA	p.E1084K	PHLDB2_uc003dyc.2_Missense_Mutation_p.E1068K|PHLDB2_uc003dyd.2_Missense_Mutation_p.E1041K|PHLDB2_uc003dyg.2_Missense_Mutation_p.E1084K|PHLDB2_uc003dyh.2_Missense_Mutation_p.E1041K|PHLDB2_uc003dyi.2_Missense_Mutation_p.E575K|PHLDB2_uc003dyj.2_Missense_Mutation_p.E139K	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1084	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						ATTACAGGAAGAAACTAGCCA	0.433											OREG0015707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	6	22										A	111686606	G	A	111686606	3	1	62	1	0	0	0	0	1	0	0	0	11852	943	33	1	3389	1	PHLDB2	3	111686606	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	13834446	111686606	86335824	132	18057										
KIAA2018	205717	broad.mit.edu	37	chr3	113376375	113376375	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggttgctaacaggcacaactGagtttgaagaattaggaggg	14	5	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:113376375G>A	uc003eam.2	-	7	4565	c.4154C>T	c.(4153-4155)TCA>TTA	p.S1385L	KIAA2018_uc003eal.2_Missense_Mutation_p.S1329L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1385					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AGGCACAACTGAGTTTGAAGA	0.448													0	0	0	0.00245	0	13	53										A	113376375	G	A	113376375	3	1	62	1	0	0	0	0	1	0	0	0	8268	1294	45	1	2587	1	KIAA2018	3	113376375	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1689769	113376375	84646055	133	18058										
ZBTB20	26137	broad.mit.edu	37	chr3	114070334	114070334	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atccccgggaacacatcgccCacgttctgtgacacgatgcg	10	15	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:114070334C>T	uc003ebi.2	-	4	771	c.591G>A	c.(589-591)GTG>GTA	p.V197V	ZBTB20_uc003ebj.2_Silent_p.V124V|ZBTB20_uc010hqp.2_Silent_p.V124V|ZBTB20_uc003ebk.2_Silent_p.V124V|ZBTB20_uc003ebl.2_Silent_p.V124V|ZBTB20_uc003ebm.2_Silent_p.V124V|ZBTB20_uc003ebn.2_Silent_p.V124V|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		ACACATCGCCCACGTTCTGTG	0.652													0	0	0	0.010729	0	10	79										T	114070334	C	T	114070334	2	4	62	1	0	0	0	0	0	0	0	1	17526	581	21	2		2	ZBTB20	3	114070334	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	693959	114070334	83952096	134	18059										
ACPP	55	broad.mit.edu	37	chr3	132068810	132068810	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cacatgaagagagcaactcaGataccaagctacaaaaaact	6	10	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:132068810G>C	uc010htp.2	+	8	918	c.828G>C	c.(826-828)CAG>CAC	p.Q276H	ACPP_uc003eon.3_Missense_Mutation_p.Q243H|ACPP_uc003eop.3_Missense_Mutation_p.Q276H	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	276						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						GAGCAACTCAGATACCAAGCT	0.299													0	0	0	0.006214	0	10	61										C	132068810	G	C	132068810	3	2	62	1	0	0	0	0	1	0	0	0	167	933	33	1	858	1	ACPP	3	132068810	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	17998476	132068810	65953620	135	18060										
CEP63	80254	broad.mit.edu	37	chr3	134278032	134278032	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gacatgatggaataaagactGagcactacaaaacagatctt	8	7	1	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:134278032G>A	uc003eqo.1	+	15	2163	c.1714G>A	c.(1714-1716)GAG>AAG	p.E572K	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	572					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						AATAAAGACTGAGCACTACAA	0.433													0	0	0	0.01441	0	56	103										A	134278032	G	A	134278032	3	1	62	1	0	0	0	0	1	0	0	0	3257	1291	45	1	1764	1	CEP63	3	134278032	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2209222	134278032	63744398	136	18061										
DZIP1L	199221	broad.mit.edu	37	chr3	137822364	137822364	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agcagctgctgcagggtgctGatcatcttgcgacgccggcg	15	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:137822364G>T	uc003erq.2	-	2	813	c.450C>A	c.(448-450)ATC>ATA	p.I150I	DZIP1L_uc003err.1_Silent_p.I150I	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	150						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						GCAGGGTGCTGATCATCTTGC	0.662													1	0	2.27111e-07	0.013537	2.39432e-07	12	26										T	137822364	G	T	137822364	2	4	62	1	0	0	0	0	0	0	0	1	4864	1280	45	3		3	DZIP1L	3	137822364	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3544332	137822364	60200066	137	18062										
SMC4	10051	broad.mit.edu	37	chr3	160148850	160148850	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagagatccagaaagaacatCgcaatctgcttcaagaatta	7	9	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:160148850C>T	uc003fdh.2	+	20	3084	c.2971C>T	c.(2971-2973)CGC>TGC	p.R991C	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.R966C|SMC4_uc003fdj.2_Missense_Mutation_p.R991C|SMC4_uc010hwd.2_Intron|SMC4_uc003fdl.2_Missense_Mutation_p.R694C	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	991	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAAAGAACATCGCAATCTGCT	0.333													0	0	0	0.014323	0	21	50										T	160148850	C	T	160148850	3	4	62	1	0	0	0	0	1	0	0	0	14785	884	31	1	3045	1	SMC4	3	160148850	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	22326486	160148850	37873580	138	18063										
SAMD7	344658	broad.mit.edu	37	chr3	169654187	169654187	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tactcacagaagagcatcttCgaggcactatgggattaaag	10	8	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:169654187C>T	uc003fgd.2	+	8	1369	c.1102C>T	c.(1102-1104)CGA>TGA	p.R368*	SAMD7_uc003fge.2_Nonsense_Mutation_p.R368*|SAMD7_uc011bpo.1_Nonsense_Mutation_p.R269*	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	368	SAM.									skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGAGCATCTTCGAGGCACTAT	0.353													0	0	0	0.008871	0	15	91										T	169654187	C	T	169654187	4	4	62	1	0	0	0	0	0	1	0	0	13824	876	31	1	1124	1	SAMD7	3	169654187	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	9505337	169654187	28368243	139	18064										
FETUB	26998	broad.mit.edu	37	chr3	186370280	186370280	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	taaccacgaatccccagggaGaaaccctggatatttccttc	7	13	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:186370280G>A	uc010hyq.2	+	8	1270	c.1009G>A	c.(1009-1011)GAA>AAA	p.E337K	FETUB_uc011brz.1_Missense_Mutation_p.E189K|FETUB_uc003fqn.2_Missense_Mutation_p.E337K|FETUB_uc003fqo.2_Missense_Mutation_p.E232K|FETUB_uc010hyr.2_Missense_Mutation_p.E300K|FETUB_uc010hys.2_Missense_Mutation_p.E189K|FETUB_uc003fqp.3_Missense_Mutation_p.E272K	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	337						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TCCCCAGGGAGAAACCCTGGA	0.522													0	0	0	0.012319	0	17	98										A	186370280	G	A	186370280	3	1	62	1	0	0	0	0	1	0	0	0	5821	943	33	1	1035	1	FETUB	3	186370280	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	16716093	186370280	11652150	140	18065										
RFC4	5984	broad.mit.edu	37	chr3	186509528	186509528	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcttaccccggcaatgtctgTaatcactttctctgtgatct	6	12	5	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:186509528T>C	uc003fqz.2	-	8	1010	c.787A>G	c.(787-789)ACA>GCA	p.T263A	RFC4_uc011bsc.1_Missense_Mutation_p.T263A|RFC4_uc011bsd.1_Missense_Mutation_p.T263A	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	263					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		GCAATGTCTGTAATCACTTTC	0.328													0	0	0	0.004672	0	3	126										C	186509528	T	C	186509528	3	2	62	1	0	0	0	0	1	0	0	0	13247	1638	57	5	320	5	RFC4	3	186509528	Missense_Mutation	SNP	T	TCGA-DK-A3IT-01A-31D-A20D-08	139248	186509528	11512902	141	18066										
TNIP2	79155	broad.mit.edu	37	chr4	2746230	2746230	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaagtcatccttgtaagcgaGaatctgaagagaggcgagac	13	7	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:2746230G>A	uc003gfg.2	-	5	997	c.910C>T	c.(910-912)CTC>TTC	p.L304F	TNIP2_uc003gff.2_Missense_Mutation_p.L197F|TNIP2_uc003gfh.2_Missense_Mutation_p.L221F	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	304	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGTAAGCGAGAATCTGAAGA	0.552													0	0	0	0.008361	0	23	44										A	2746230	G	A	2746230	3	1	62	1	0	0	0	0	1	0	0	0	16312	942	33	1	387	1	TNIP2	4	2746230	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		2746230	188408046	142	18067										
RASL11B	65997	broad.mit.edu	37	chr4	53728708	53728708	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agaacatgtgcaccatcgccGagtaccccgcgccgggcaac	11	16	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:53728708G>A	uc003gzt.2	+	1	214	c.34G>A	c.(34-36)GAG>AAG	p.E12K		NM_023940	NP_076429	Q9BPW5	RSLBB_HUMAN	RAS-like family 11 member B	12					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0302)			CACCATCGCCGAGTACCCCGC	0.731													0	0	0	0.00308	0	7	25										A	53728708	G	A	53728708	3	1	62	1	0	0	0	0	1	0	0	0	13082	1059	37	1	36	1	RASL11B	4	53728708	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	50982478	53728708	137425568	143	18068										
PTPN13	5783	broad.mit.edu	37	chr4	87622590	87622590	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acattctccccttaccagttCaaaactagtggcccagaaaa	5	13	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:87622590C>G	uc003hpz.2	+	7	1311	c.831C>G	c.(829-831)TTC>TTG	p.F277L	PTPN13_uc003hpy.2_Missense_Mutation_p.F277L|PTPN13_uc003hqa.2_Missense_Mutation_p.F277L|PTPN13_uc003hqb.2_Missense_Mutation_p.F277L	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	277						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CTTACCAGTTCAAAACTAGTG	0.393													0	0	0	0.004482	0	7	11										G	87622590	C	G	87622590	3	3	62	1	0	0	0	0	1	0	0	0	12782	825	29	1	853	1	PTPN13	4	87622590	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	33893882	87622590	103531686	144	18069										
PALLD	23022	broad.mit.edu	37	chr4	169433469	169433469	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tccacttcccagctgcacctCgattcatccaaaagctgagg	7	15	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:169433469C>G	uc011cjx.1	+	2	1025	c.814C>G	c.(814-816)CGA>GGA	p.R272G	PALLD_uc003iru.2_Missense_Mutation_p.R272G	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	272	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCTGCACCTCGATTCATCCA	0.567									Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.001168	0	4	41										G	169433469	C	G	169433469	3	3	62	1	0	0	0	0	1	0	0	0	11407	876	31	1	816	1	PALLD	4	169433469	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	81810879	169433469	21720807	145	18070										
SLC6A18	348932	broad.mit.edu	37	chr5	1245984	1245984	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agctgttcccctcgcgtcagGagaagctctacccgggctgg	13	14	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:1245984G>C	uc003jby.1	+	12	1801	c.1678G>C	c.(1678-1680)GAG>CAG	p.E560Q		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	560	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCGCGTCAGGAGAAGCTCTA	0.706													0	0	0	0.001168	0	5	34										C	1245984	G	C	1245984	3	2	62	1	0	0	0	0	1	0	0	0	14681	1175	41	1	1724	1	SLC6A18	5	1245984	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		1245984	179669276	146	18071										
CCT5	22948	broad.mit.edu	37	chr5	10258507	10258507	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcccccatagaaagtggaaGatgcgaagattgcaattctc	9	9	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:10258507G>A	uc003jeq.2	+	6	904	c.733G>A	c.(733-735)GAT>AAT	p.D245N	CCT5_uc011cmq.1_Missense_Mutation_p.D92N|CCT5_uc003jer.2_Missense_Mutation_p.D245N|CCT5_uc010its.2_Missense_Mutation_p.D245N|CCT5_uc011cmr.1_Missense_Mutation_p.D190N|CCT5_uc011cms.1_Missense_Mutation_p.D207N|CCT5_uc011cmt.1_Missense_Mutation_p.D152N	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	245					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GAAAGTGGAAGATGCGAAGAT	0.408													0	0	0	0.010504	0	17	109										A	10258507	G	A	10258507	3	1	62	1	0	0	0	0	1	0	0	0	2956	942	33	1	755	1	CCT5	5	10258507	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	9012523	10258507	170656753	147	18072										
DNAH5	1767	broad.mit.edu	37	chr5	13708301	13708301	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tctcgcagattttcgctcatGatgatggtgccatcaatagc	9	10	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:13708301G>A	uc003jfd.2	-	76	13311	c.13269C>T	c.(13267-13269)ATC>ATT	p.I4423I	DNAH5_uc003jfc.2_Silent_p.I591I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4423					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTCGCTCATGATGATGGTGC	0.458									Kartagener_syndrome				0	0	0	0.01441	0	73	198										A	13708301	G	A	13708301	2	1	62	1	0	0	0	0	0	0	0	1	4604	1280	45	1		1	DNAH5	5	13708301	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3449794	13708301	167206959	148	18073										
UGT3A1	133688	broad.mit.edu	37	chr5	35965895	35965895	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaaagaacagaaatcaaatgCttcaacaaataccagatcat	5	8	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:35965895C>T	uc003jjv.1	-	4	593	c.436G>A	c.(436-438)GCA>ACA	p.A146T	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.A146T|UGT3A1_uc011cor.1_Missense_Mutation_p.A112T|UGT3A1_uc003jjy.1_Missense_Mutation_p.A92T	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	146	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATCAAATGCTTCAACAAAT	0.383													0	0	0	0.003954	0	21	36										T	35965895	C	T	35965895	3	4	62	1	0	0	0	0	1	0	0	0	16960	797	28	2	1233	2	UGT3A1	5	35965895	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	22257594	35965895	144949365	149	18074										
RICTOR	253260	broad.mit.edu	37	chr5	38952313	38952313	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcactcgatggcacagattCactttcactattatgtctag	6	11	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:38952313C>A	uc003jlp.2	-	30	3136	c.3112G>T	c.(3112-3114)GAA>TAA	p.E1038*	RICTOR_uc003jlo.2_Nonsense_Mutation_p.E1038*|RICTOR_uc010ivf.2_Nonsense_Mutation_p.E753*	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1038	Ser-rich.				actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GGCACAGATTCACTTTCACTA	0.343													1	0	1.1804e-14	0.003954	1.30089e-14	21	23										A	38952313	C	A	38952313	4	1	62	1	0	0	0	0	0	1	0	0	13358	835	29	3	2050	3	RICTOR	5	38952313	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2986418	38952313	141962947	150	18075										
PPAP2A	8611	broad.mit.edu	37	chr5	54721117	54721117	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agagtcctcctcttttctttCtttaaaagaagttctttctt	4	9	5	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54721117C>G	uc003jqa.2	-	6	1188	c.772G>C	c.(772-774)GAA>CAA	p.E258Q	SKIV2L2_uc003jpy.3_3'UTR|SKIV2L2_uc011cqi.1_3'UTR|PPAP2A_uc003jpz.2_Missense_Mutation_p.E259Q|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	258	Cytoplasmic (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				TCTTTTCTTTCTTTAAAAGAA	0.378													0	0	0	0.00308	0	6	39										G	54721117	C	G	54721117	3	3	62	1	0	0	0	0	1	0	0	0	12290	922	32	1	86	1	PPAP2A	5	54721117	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	15768804	54721117	126194143	151	18076										
PPAP2A	8611	broad.mit.edu	37	chr5	54721830	54721830	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcagtgtggggcgtaagagtCttgcccagtctcccttcatc	12	12	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54721830C>G	uc003jqa.2	-	5	1003	c.587G>C	c.(586-588)AGA>ACA	p.R196T	PPAP2A_uc003jpz.2_Missense_Mutation_p.R197T|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	196	Cytoplasmic (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GCGTAAGAGTCTTGCCCAGTC	0.378													0	0	0	0.001855	0	11	55										G	54721830	C	G	54721830	3	3	62	1	0	0	0	0	1	0	0	0	12290	913	32	1	275	1	PPAP2A	5	54721830	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	713	54721830	126193430	152	18077										
PPAP2A	8611	broad.mit.edu	37	chr5	54737722	54737722	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggaaaacgaagagtggcctGaatagaaggacaacctggaa	13	6	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54737722G>C	uc003jqa.2	-	4	922	c.506C>G	c.(505-507)TCA>TGA	p.S169*	PPAP2A_uc003jpz.2_Nonsense_Mutation_p.S170*|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	169	Helical; (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				AGAGTGGCCTGAATAGAAGGA	0.393													0	0	0	0.008361	0	26	45										C	54737722	G	C	54737722	4	2	62	1	0	0	0	0	0	1	0	0	12290	1294	45	1	360	1	PPAP2A	5	54737722	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	15892	54737722	126177538	153	18078										
CHD1	1105	broad.mit.edu	37	chr5	98215419	98215419	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtcatcctcatccatatttGagaagttggcaacctgataa	7	9	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:98215419G>C	uc003knf.2	-	22	3222	c.3074C>G	c.(3073-3075)TCA>TGA	p.S1025*		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1025					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATCCATATTTGAGAAGTTGGC	0.343													0	0	0	0.009096	0	3	10										C	98215419	G	C	98215419	4	2	62	1	0	0	0	0	0	1	0	0	3323	1294	45	1	2114	1	CHD1	5	98215419	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	43477697	98215419	82699841	154	18079										
WDR36	134430	broad.mit.edu	37	chr5	110428137	110428137	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caggaccagagctgagaggaGctgggatcgcggcggcaatg	18	9	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:110428137G>C	uc003kpd.2	+	1	268	c.151G>C	c.(151-153)GCT>CCT	p.A51P	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	51					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GCTGAGAGGAGCTGGGATCGC	0.602													0	0	0	0.008291	0	7	48										C	110428137	G	C	110428137	3	2	62	1	0	0	0	0	1	0	0	0	17287	971	34	4	153	4	WDR36	5	110428137	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	12212718	110428137	70487123	155	18080										
SRP19	6728	broad.mit.edu	37	chr5	112227372	112227372	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aagatgacgtttcccaagaaGatgacatttccagagaaacc	8	9	0	6			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:112227372G>C	uc011cvv.1	+	4	366	c.111G>C	c.(109-111)AAG>AAC	p.K37N	SRP19_uc011cvu.1_Missense_Mutation_p.K22N|REEP5_uc011cvw.1_Intron|REEP5_uc003kqe.1_Intron|REEP5_uc011cvx.1_Intron|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_Intron			P09132	SRP19_HUMAN	SubName: Full=Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2;	Error:Variant_position_missing_in_P09132_after_alignment					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		TTCCCAAGAAGATGACATTTC	0.473													0	0	0	0.009096	0	4	11										C	112227372	G	C	112227372	3	2	62	1	0	0	0	0	1	0	0	0	15153	957	33	1		1	SRP19	5	112227372	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1799235	112227372	68687888	156	18081										
PHF15	23338	broad.mit.edu	37	chr5	133914845	133914845	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccaccttcagctgtggctgaGaggcccaaggtcagcctgca	12	14	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:133914845G>A	uc003kzo.1	+	11	2390	c.2211G>A	c.(2209-2211)GAG>GAA	p.E737E	PHF15_uc011cxt.1_Silent_p.E781E|PHF15_uc003kzk.2_Silent_p.E797E|PHF15_uc003kzm.2_Silent_p.E738E|PHF15_uc003kzn.2_3'UTR	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	737					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGTGGCTGAGAGGCCCAAGG	0.622													0	0	0	0.008291	0	9	62										A	133914845	G	A	133914845	2	1	62	1	0	0	0	0	0	0	0	1	11826	933	33	1		1	PHF15	5	133914845	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	21687473	133914845	47000415	157	18082										
SEC24A	10802	broad.mit.edu	37	chr5	134029515	134029515	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgcaggctgcctttaagctGatgtctccaactggtggtcg	12	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:134029515G>A	uc003kzs.2	+	13	2166	c.1878G>A	c.(1876-1878)CTG>CTA	p.L626L	SEC24A_uc011cxu.1_Silent_p.L390L	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	626					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTTTAAGCTGATGTCTCCAA	0.498													0	0	0	0.006214	0	9	48										A	134029515	G	A	134029515	2	1	62	1	0	0	0	0	0	0	0	1	13994	1277	45	1		1	SEC24A	5	134029515	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	114670	134029515	46885745	158	18083										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139916980	139916980	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcacctctttcagccacttCtgccccaccaacgttgggcc	6	18	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:139916980C>G	uc003lfs.1	+	31	7158	c.7034C>G	c.(7033-7035)TCT>TGT	p.S2345C	ANKHD1_uc003lfr.2_Missense_Mutation_p.S2345C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S1101C|ANKHD1_uc003lfw.2_Missense_Mutation_p.S1000C|ANKHD1_uc010jfl.2_Missense_Mutation_p.S721C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.S499C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2345						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCCACTTCTGCCCCACCA	0.453													0	0	0	0.010818	0	25	91										G	139916980	C	G	139916980	3	3	62	1	0	0	0	0	1	0	0	0	629	913	32	1	7156	1	ANKHD1-EIF4EBP3	5	139916980	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5887465	139916980	40998280	159	18084										
APBB3	10307	broad.mit.edu	37	chr5	139941016	139941016	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agaggcatcaccactgacctCtactcgctctgacaagatct	7	14	4	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:139941016C>A	uc003lgd.1	-	8	1140	c.781G>T	c.(781-783)GAG>TAG	p.E261*	APBB3_uc003lgb.1_Nonsense_Mutation_p.E33*|APBB3_uc003lgc.1_Nonsense_Mutation_p.E33*|APBB3_uc003lge.1_Nonsense_Mutation_p.E254*|APBB3_uc003lgf.1_RNA|APBB3_uc010jfp.1_RNA|APBB3_uc011czi.1_Nonsense_Mutation_p.E33*|APBB3_uc010jfq.1_Nonsense_Mutation_p.E33*	NM_133172	NP_573418	O95704	APBB3_HUMAN	amyloid beta precursor protein-binding, family	256	PID 1.					actin cytoskeleton|cytoplasm				ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACTGACCTCTACTCGCTCT	0.547													1	0	8.24728e-16	0.004656	9.17589e-16	23	141										A	139941016	C	A	139941016	4	1	62	1	0	0	0	0	0	1	0	0	762	922	32	3	714	3	APBB3	5	139941016	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	24036	139941016	40974244	160	18085										
PCDHA12	56137	broad.mit.edu	37	chr5	140257094	140257094	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggccaggccccaaagacgtcGtcgcgggcctcagtgggcgc	16	15	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:140257094G>A	uc003lic.2	+	1	2164	c.2037G>A	c.(2035-2037)TCG>TCA	p.S679S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.S679S	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	679	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGACGTCGTCGCGGGCCT	0.657													0	0	0	0.004672	0	3	37										A	140257094	G	A	140257094	2	1	62	1	0	0	0	0	0	0	0	1	11522	1132	40	2		2	PCDHA12	5	140257094	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	316078	140257094	40658166	161	18086										
PCDHGA10	56106	broad.mit.edu	37	chr5	140795020	140795020	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcctgcagacctattcccacGaggtctctctcaccgcggac	8	17	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:140795020G>A	uc003lkl.1	+	1	2278	c.2278G>A	c.(2278-2280)GAG>AAG	p.E760K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.E760K|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCCCACGAGGTCTCTCT	0.602													0	0	0	0.01441	0	56	107										A	140795020	G	A	140795020	3	1	62	1	0	0	0	0	1	0	0	0	11551	1059	37	1	2280	1	PCDHGA10	5	140795020	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	537926	140795020	40120240	162	18087										
PCDH12	51294	broad.mit.edu	37	chr5	141334867	141334867	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcctctgcctgggatggttGaaaaggaggttgaccgtgtc	14	8	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:141334867G>C	uc003llx.2	-	1	3761	c.2550C>G	c.(2548-2550)TTC>TTG	p.F850L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	850	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGATGGTTGAAAAGGAGGT	0.627													0	0	0	0.014323	0	18	70										C	141334867	G	C	141334867	3	2	62	1	0	0	0	0	1	0	0	0	11510	1281	45	1	1020	1	PCDH12	5	141334867	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	539847	141334867	39580393	163	18088										
PCDH12	51294	broad.mit.edu	37	chr5	141336269	141336269	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggaccaaaccattgtgtcctGaatccaagtcatctgccatg	8	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:141336269G>A	uc003llx.2	-	1	2359	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	383	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGTGTCCTGAATCCAAGTC	0.507													0	0	0	0.00278	0	20	94										A	141336269	G	A	141336269	3	1	62	1	0	0	0	0	1	0	0	0	11510	1294	45	1	2422	1	PCDH12	5	141336269	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1402	141336269	39578991	164	18089										
SLC36A3	285641	broad.mit.edu	37	chr5	150675819	150675819	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccccgatggccagaaggctgAcaggaccgacctggagggga	16	12	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:150675819A>G	uc003ltw.2	-	3	649	c.230T>C	c.(229-231)GTC>GCC	p.V77A	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Missense_Mutation_p.V21A|SLC36A3_uc003ltx.2_Missense_Mutation_p.V77A	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	77	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGAAGGCTGACAGGACCGAC	0.597													0	0	0	0.00308	0	7	30										G	150675819	A	G	150675819	3	3	62	1	0	0	0	0	1	0	0	0	14595	275	10	5	1341	5	SLC36A3	5	150675819	Missense_Mutation	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	9339550	150675819	30239441	165	18090										
NOP16	51491	broad.mit.edu	37	chr5	175811345	175811345	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatctgttttggggtatcttGatagtaattcttctcatcac	7	7	5	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:175811345G>C	uc011dfl.1	-	5	424	c.424C>G	c.(424-426)CAA>GAA	p.Q142E	NOP16_uc003med.2_Intron|NOP16_uc003mee.2_Intron	NM_016391	NP_057475	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein homolog	142						nucleolus				ovary(1)|central_nervous_system(1)	2						GGGGTATCTTGATAGTAATTC	0.448													0	0	0	0.001168	0	6	45										C	175811345	G	C	175811345	3	2	62	1	0	0	0	0	1	0	0	0	10537	1299	45	1	115	1	NOP16	5	175811345	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	25135526	175811345	5103915	166	18091										
GPLD1	2822	broad.mit.edu	37	chr6	24486344	24486344	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attgtgaagctgaagaaactCcagagctctgtgtcctgaga	11	8	1	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:24486344C>T	uc003ned.1	-	2	223	c.112G>A	c.(112-114)GAG>AAG	p.E38K	GPLD1_uc010jps.1_Missense_Mutation_p.E38K|GPLD1_uc003nee.2_Missense_Mutation_p.E38K	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	38						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						TGAAGAAACTCCAGAGCTCTG	0.323													0	0	0	0.009535	0	20	129										T	24486344	C	T	24486344	3	4	62	1	0	0	0	0	1	0	0	0	6614	864	30	1	2547	1	GPLD1	6	24486344	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		24486344	146628723	167	18092										
HIST1H1C	3006	broad.mit.edu	37	chr6	26056443	26056443	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgttgtttttctccacatCatagccggcggcagccaacg	10	13	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:26056443C>G	uc003nfw.2	-	1	257	c.214G>C	c.(214-216)GAT>CAT	p.D72H		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	72	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TTCTCCACATCATAGCCGGCG	0.557													0	0	0	0.010504	0	18	87										G	26056443	C	G	26056443	3	3	62	1	0	0	0	0	1	0	0	0	7124	826	29	1	431	1	HIST1H1C	6	26056443	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1570099	26056443	145058624	168	18093										
HIST1H1T	3010	broad.mit.edu	37	chr6	26108038	26108038	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccctggtttgcaccaggattCccttgttcactaagctcttg	8	13	2	0	rs147905742		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:26108038C>A	uc003ngj.2	-	1	327	c.284G>T	c.(283-285)GGA>GTA	p.G95V		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	95	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CACCAGGATTCCCTTGTTCAC	0.478													1	0	1.17739e-12	0.005443	1.27825e-12	23	55										A	26108038	C	A	26108038	3	1	62	1	0	0	0	0	1	0	0	0	7127	855	30	3	343	3	HIST1H1T	6	26108038	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	51595	26108038	145007029	169	18094										
HIST1H2AG	8969	broad.mit.edu	37	chr6	27100906	27100906	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cgctaaggccaagactcgctCttctagggccggtctccagt	11	14	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:27100906C>T	uc003niw.2	+	1	90	c.56C>T	c.(55-57)TCT>TTT	p.S19F	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	19					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						AAGACTCGCTCTTCTAGGGCC	0.642													0	0	0	0.00632	0	24	34										T	27100906	C	T	27100906	3	4	62	1	0	0	0	0	1	0	0	0	7133	913	32	1	58	1	HIST1H2AG	6	27100906	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	992868	27100906	144014161	170	18095										
HIST1H2AK	8330	broad.mit.edu	37	chr6	27805994	27805994	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cgctccggcaccgacccgctCagcgtagttgcccttgcgga	12	17	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:27805994C>T	uc003njs.2	-	1	124	c.124G>A	c.(124-126)GAG>AAG	p.E42K	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	42					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						CCGACCCGCTCAGCGTAGTTG	0.657													0	0	0	0.00245	0	12	38										T	27805994	C	T	27805994	3	4	62	1	0	0	0	0	1	0	0	0	7137	835	29	1	272	1	HIST1H2AK	6	27805994	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	705088	27805994	143309073	171	18096										
DDR1	780	broad.mit.edu	37	chr6	30865172	30865172	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccaggaatgatttcctgaaaGaggtgaagatcatgtcgagg	13	6	1	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:30865172G>C	uc003nrr.2	+	16	2273	c.2014G>C	c.(2014-2016)GAG>CAG	p.E672Q	DDR1_uc010jse.2_Missense_Mutation_p.E635Q|DDR1_uc003nrq.2_Missense_Mutation_p.E635Q|DDR1_uc003nrs.2_Missense_Mutation_p.E672Q|DDR1_uc003nrt.2_Missense_Mutation_p.E635Q|DDR1_uc011dms.1_Missense_Mutation_p.E653Q|DDR1_uc003nru.2_Missense_Mutation_p.E635Q|DDR1_uc003nrv.2_Missense_Mutation_p.E678Q|DDR1_uc003nrw.1_Missense_Mutation_p.E407Q|DDR1_uc003nrz.1_5'UTR	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	672	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	TTTCCTGAAAGAGGTGAAGAT	0.587													0	0	0	0.010504	0	16	58										C	30865172	G	C	30865172	3	2	62	1	0	0	0	0	1	0	0	0	4336	943	33	1	2086	1	DDR1	6	30865172	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3059178	30865172	140249895	172	18097										
MICA	4276	broad.mit.edu	37	chr6	31382788	31382788	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccatttccctcttttctccaGagctcgtgagcctgcaggtc	8	15	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31382788G>A	uc003ntk.1	+	7	1064	c.1025_splice	c.e7-1							RecName: Full=MHC class I polypeptide-related sequence A;          Short=MIC-A; Flags: Precursor;												0		Ovarian(999;0.0253)				CTTTTCTCCAGAGCTCGTGAG	0.522													0	0	0	0.010729	0	9	73										A	31382788	G	A	31382788	5	1	62	1	0	0	0	0	0	0	1	0	9568	956	33	1	1050	1	MICA	6	31382788	Splice_Site	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	517616	31382788	139732279	173	18098										
CSNK2B	1460	broad.mit.edu	37	chr6	31635728	31635728	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tatcgacaagctctagacatGatcttggacctggagcctgg	11	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31635728G>T	uc003nvr.1	+	3	496	c.156G>T	c.(154-156)ATG>ATT	p.M52I	BAT4_uc003nvn.2_5'Flank|BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_Missense_Mutation_p.M52I|CSNK2B_uc003nvs.1_Missense_Mutation_p.M52I|LY6G5B_uc003nvt.1_5'Flank	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	52					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						CTCTAGACATGATCTTGGACC	0.458													1	0	0.00185496	0.001855	0.0019073	8	55										T	31635728	G	T	31635728	3	4	62	1	0	0	0	0	1	0	0	0	3959	1290	45	3	162	3	CSNK2B	6	31635728	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	252940	31635728	139479339	174	18099										
BAT5	7920	broad.mit.edu	37	chr6	31657862	31657862	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gagatggtctcaccgtgcttCcagcaaagcctggatgattc	11	11	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31657862C>T	uc003nvy.1	-	11	980	c.950G>A	c.(949-951)GGA>GAA	p.G317E	BAT5_uc003nvx.1_Missense_Mutation_p.G98E|BAT5_uc011dny.1_Missense_Mutation_p.G284E|BAT5_uc003nvz.1_Missense_Mutation_p.G98E|BAT5_uc011dnz.1_Missense_Mutation_p.G98E|BAT5_uc010jtc.1_RNA	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	317						integral to membrane	hydrolase activity|protein binding				0						CACCGTGCTTCCAGCAAAGCC	0.542													0	0	0	0.013537	0	8	59										T	31657862	C	T	31657862	3	4	62	1	0	0	0	0	1	0	0	0	1324	855	30	1	766	1	BAT5	6	31657862	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	22134	31657862	139457205	175	18100										
PTK7	5754	broad.mit.edu	37	chr6	43096807	43096807	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcgctgtgaggttgaggctCcgggcccggtacatgtgtac	15	10	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:43096807C>G	uc003oub.1	+	2	370	c.172C>G	c.(172-174)CCG>GCG	p.P58A	PTK7_uc003ouc.1_Missense_Mutation_p.P58A|PTK7_uc003oud.1_Missense_Mutation_p.P58A|PTK7_uc003oue.1_Missense_Mutation_p.P58A|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.P66A|PTK7_uc003oua.2_Missense_Mutation_p.P58A	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	58	Ig-like C2-type 1.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGTTGAGGCTCCGGGCCCGGT	0.642													0	0	0	0.004007	0	11	16										G	43096807	C	G	43096807	3	3	62	1	0	0	0	0	1	0	0	0	12765	855	30	1	178	1	PTK7	6	43096807	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	11438945	43096807	128018260	176	18101										
XPO5	57510	broad.mit.edu	37	chr6	43516011	43516011	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctttacctgtgcatgtcttGagaaagccagatgctggcca	10	11	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:43516011G>A	uc003ovp.2	-	18	2258	c.2047C>T	c.(2047-2049)CAA>TAA	p.Q683*		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	683					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TGCATGTCTTGAGAAAGCCAG	0.502													0	0	0	0.005443	0	22	94										A	43516011	G	A	43516011	4	1	62	1	0	0	0	0	0	1	0	0	17444	1299	45	1	1627	1	XPO5	6	43516011	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	419204	43516011	127599056	177	18102										
OPN5	221391	broad.mit.edu	37	chr6	47775996	47775996	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctccattcccatacagctctCtgtggtgccaaccctacttg	6	16	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:47775996C>T	uc003ozc.2	+	5	868	c.863C>T	c.(862-864)TCT>TTT	p.S288F	OPN5_uc003ozd.2_Missense_Mutation_p.S123F	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	288	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						ATACAGCTCTCTGTGGTGCCA	0.453													0	0	0	0.009535	0	25	130										T	47775996	C	T	47775996	3	4	62	1	0	0	0	0	1	0	0	0	10883	913	32	1	881	1	OPN5	6	47775996	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4259985	47775996	123339071	178	18103										
PHF3	23469	broad.mit.edu	37	chr6	64390047	64390047	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gatctccaagaaaatcacctCgtttaatggcacaaggtaat	7	9	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:64390047C>T	uc003pep.1	+	2	417	c.391C>T	c.(391-393)CGT>TGT	p.R131C	PHF3_uc010kaf.1_Missense_Mutation_p.R131C|PHF3_uc003pem.2_Missense_Mutation_p.R84C|PHF3_uc010kag.1_Missense_Mutation_p.R43C|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Missense_Mutation_p.R43C|PHF3_uc011dxs.1_5'UTR|PHF3_uc003peo.2_Missense_Mutation_p.R131C	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	131					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAATCACCTCGTTTAATGGC	0.383													0	0	0	0.012319	0	18	93										T	64390047	C	T	64390047	3	4	62	1	0	0	0	0	1	0	0	0	11836	884	31	1	397	1	PHF3	6	64390047	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	16614051	64390047	106725020	179	18104										
IBTK	25998	broad.mit.edu	37	chr6	82927697	82927697	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctttcttttcagaactctttCttttctcttcaaaccatctc	1	13	7	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:82927697C>G	uc003pjl.1	-	10	1933	c.1406G>C	c.(1405-1407)AGA>ACA	p.R469T	IBTK_uc011dyv.1_Missense_Mutation_p.R469T|IBTK_uc011dyw.1_Missense_Mutation_p.R469T|IBTK_uc010kbi.1_Missense_Mutation_p.R163T|IBTK_uc003pjm.2_Missense_Mutation_p.R469T	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	469					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		AGAACTCTTTCTTTTCTCTTC	0.318													0	0	0	0.008291	0	9	29										G	82927697	C	G	82927697	3	3	62	1	0	0	0	0	1	0	0	0	7476	913	32	1	2735	1	IBTK	6	82927697	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	18537650	82927697	88187370	180	18105										
SLC35F1	222553	broad.mit.edu	37	chr6	118588187	118588187	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgttttgtgatcccagtcgtGattttgctctcctggttctt	9	9	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:118588187G>A	uc003pxx.3	+	4	708	c.507G>A	c.(505-507)GTG>GTA	p.V169V	SLC35F1_uc003pxy.1_5'UTR	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	169	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TCCCAGTCGTGATTTTGCTCT	0.502													0	0	0	0.01441	0	56	332										A	118588187	G	A	118588187	2	1	62	1	0	0	0	0	0	0	0	1	14588	1277	45	1		1	SLC35F1	6	118588187	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	35660490	118588187	52526880	181	18106										
MYB	4602	broad.mit.edu	37	chr6	135511379	135511379	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcataaccacttgaatccaGaagttaagaaaacctcctgg	8	10	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:135511379G>C	uc003qfc.2	+	5	620	c.421G>C	c.(421-423)GAA>CAA	p.E141Q	MYB_uc003qfh.2_Missense_Mutation_p.E141Q|MYB_uc003qfi.2_Missense_Mutation_p.E141Q|MYB_uc010kgi.2_Missense_Mutation_p.E141Q|MYB_uc003qfq.2_Missense_Mutation_p.E141Q|MYB_uc010kgj.2_Missense_Mutation_p.E141Q|MYB_uc003qfo.2_Missense_Mutation_p.E141Q|MYB_uc003qfu.2_Missense_Mutation_p.E141Q|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Intron|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Intron|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.E141Q|MYB_uc003qgd.1_5'UTR	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	141	HTH myb-type 2.|Interaction with HIPK2 and NLK (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CTTGAATCCAGAAGTTAAGAA	0.453			T	NFIB	adenoid cystic carcinoma								0	0	0	0.006214	0	9	53										C	135511379	G	C	135511379	3	2	62	1	0	0	0	0	1	0	0	0	10007	943	33	1	439	1	MYB	6	135511379	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	16923192	135511379	35603688	182	18107										
MYB	4602	broad.mit.edu	37	chr6	135539063	135539063	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggaggagcagatgacatcttCcagtcaagctcgtaaatacg	11	9	2	2	rs148508251		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:135539063C>T	uc003qfc.2	+	15	2067	c.1868C>T	c.(1867-1869)TCC>TTC	p.S623F	MYB_uc003qfh.2_Missense_Mutation_p.S744F|MYB_uc003qfi.2_Missense_Mutation_p.S728F|MYB_uc010kgi.2_Missense_Mutation_p.S586F|MYB_uc003qfq.2_Missense_Mutation_p.S741F|MYB_uc010kgj.2_Missense_Mutation_p.S588F|MYB_uc003qfo.2_Missense_Mutation_p.S538F|MYB_uc003qfu.2_Missense_Mutation_p.S620F|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Missense_Mutation_p.S249F|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.S435F|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	623					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		ATGACATCTTCCAGTCAAGCT	0.478			T	NFIB	adenoid cystic carcinoma								0	0	0	0.008291	0	10	69										T	135539063	C	T	135539063	3	4	62	1	0	0	0	0	1	0	0	0	10007	855	30	1	2293	1	MYB	6	135539063	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	27684	135539063	35576004	183	18108										
SYNE1	23345	broad.mit.edu	37	chr6	152631862	152631862	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttctgcaaacgaattttgatCatctgtcgcaactcctcagt	6	11	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:152631862C>G	uc010kiw.2	-	88	17459	c.16857G>C	c.(16855-16857)ATG>ATC	p.M5619I	SYNE1_uc010kiv.2_Missense_Mutation_p.M143I|SYNE1_uc003qos.3_Missense_Mutation_p.M143I|SYNE1_uc003qot.3_Missense_Mutation_p.M5548I|SYNE1_uc003qou.3_Missense_Mutation_p.M5619I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5619	Spectrin 17.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAATTTTGATCATCTGTCGCA	0.363										HNSCC(10;0.0054)			0	0	0	0.007413	0	15	23										G	152631862	C	G	152631862	3	3	62	1	0	0	0	0	1	0	0	0	15442	826	29	1	9845	1	SYNE1	6	152631862	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	17092799	152631862	18483205	184	18109										
SYNE1	23345	broad.mit.edu	37	chr6	152740829	152740829	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcatcaaattgctggtgttCagcaaccacagactgaagaa	8	10	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:152740829C>G	uc010kiw.2	-	40	5898	c.5296G>C	c.(5296-5298)GAA>CAA	p.E1766Q	SYNE1_uc003qot.3_Missense_Mutation_p.E1773Q|SYNE1_uc003qou.3_Missense_Mutation_p.E1766Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E1749Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1766	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCTGGTGTTCAGCAACCACA	0.348										HNSCC(10;0.0054)			0	0	0	0.00499	0	11	42										G	152740829	C	G	152740829	3	3	62	1	0	0	0	0	1	0	0	0	15442	835	29	1	21598	1	SYNE1	6	152740829	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	108967	152740829	18374238	185	18110										
MAP3K4	4216	broad.mit.edu	37	chr6	161527697	161527697	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatgttatgcacgttggcttGaggaaggtgaccttcaaatg	12	6	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:161527697G>C	uc003qtn.2	+	20	4150	c.4008G>C	c.(4006-4008)TTG>TTC	p.L1336F	MAP3K4_uc010kkc.1_Missense_Mutation_p.L1332F|MAP3K4_uc003qto.2_Missense_Mutation_p.L1286F|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.L789F|MAP3K4_uc003qtp.2_Missense_Mutation_p.L272F|MAP3K4_uc003qtq.2_Missense_Mutation_p.L25F	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1336					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ACGTTGGCTTGAGGAAGGTGA	0.378													0	0	0	0.01441	0	38	50										C	161527697	G	C	161527697	3	2	62	1	0	0	0	0	1	0	0	0	9252	1281	45	1	4086	1	MAP3K4	6	161527697	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	8786868	161527697	9587370	186	18111										
C7orf27	221927	broad.mit.edu	37	chr7	2579517	2579517	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtggcctggaaggccttcttCagaacctggagcagataggg	15	9	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:2579517C>G	uc003smi.2	-	11	1443	c.1401G>C	c.(1399-1401)CTG>CTC	p.L467L	C7orf27_uc003smh.3_5'UTR	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	467					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		AGGCCTTCTTCAGAACCTGGA	0.652													0	0	0	0.001168	0	4	5										G	2579517	C	G	2579517	2	3	62	1	0	0	0	0	0	0	0	1	2382	813	29	1		1	C7orf27	7	2579517	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		2579517	156559146	187	18112										
EIF2AK1	27102	broad.mit.edu	37	chr7	6098634	6098634	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggccctcggcgggaaagtcGatggccggcggcgcagccac	18	14	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:6098634G>C	uc003spp.2	-	1	227	c.81C>G	c.(79-81)ATC>ATG	p.I27M	EIF2AK1_uc003spq.2_Missense_Mutation_p.I27M|EIF2AK1_uc011jwm.1_Translation_Start_Site	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	27				PPAIDFPAE -> RRHRLSRR (in Ref. 1; AAF70289).	negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CGGGAAAGTCGATGGCCGGCG	0.642													0	0	0	0.009096	0	3	6										C	6098634	G	C	6098634	3	2	62	1	0	0	0	0	1	0	0	0	4996	1048	37	1	1871	1	EIF2AK1	7	6098634	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3519117	6098634	153040029	188	18113										
MPP6	51678	broad.mit.edu	37	chr7	24705264	24705264	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttccaagccagttcctggaaGagaagagaaaggcatttgtt	11	7	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:24705264G>C	uc003swx.2	+	8	1140	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	MPP6_uc003swy.2_Missense_Mutation_p.E281Q|MPP6_uc010kur.2_5'Flank	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	281	SH3.				protein complex assembly		protein binding				0						GTTCCTGGAAGAGAAGAGAAA	0.423													0	0	0	0.003163	0	12	64										C	24705264	G	C	24705264	3	2	62	1	0	0	0	0	1	0	0	0	9738	943	33	1	863	1	MPP6	7	24705264	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	18606630	24705264	134433399	189	18114										
CREB5	9586	broad.mit.edu	37	chr7	28534602	28534602	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtttccttcaataaaaacaGacaatatgttatcaggtaag	6	6	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:28534602G>C	uc003szq.2	+	3	544	c.154G>C	c.(154-156)GAC>CAC	p.D52H	CREB5_uc003szo.2_Missense_Mutation_p.D19H|CREB5_uc003szr.2_Missense_Mutation_p.D45H	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	52					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AATAAAAACAGACAATATGTT	0.408													0	0	0	0.003954	0	23	42										C	28534602	G	C	28534602	3	2	62	1	0	0	0	0	1	0	0	0	3860	942	33	1	164	1	CREB5	7	28534602	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3829338	28534602	130604061	190	18115										
PLEKHA8	84725	broad.mit.edu	37	chr7	30102287	30102287	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcttcctttattttgttttaGaggtctcaaatttttgaagg	7	5	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:30102287G>C	uc003tam.1	+	12	1321	c.1230_splice	c.e12-1	p.R410_splice	PLEKHA8_uc003tao.2_Splice_Site_p.R294_splice|PLEKHA8_uc003tap.1_Splice_Site_p.R410_splice|PLEKHA8_uc003tan.2_Splice_Site_p.R410_splice	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A						protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						TTTTGTTTTAGAGGTCTCAAA	0.328													0	0	0	0.013537	0	11	39										C	30102287	G	C	30102287	5	2	62	1	0	0	0	0	0	0	1	0	12062	956	33	1	1275	1	PLEKHA8	7	30102287	Splice_Site	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1567685	30102287	129036376	191	18116										
BBS9	27241	broad.mit.edu	37	chr7	33185904	33185904	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtgattggtggtctactattCtgggagataaagaagaattt	12	3	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:33185904C>G	uc003tdn.1	+	2	553	c.40C>G	c.(40-42)CTG>GTG	p.L14V	BBS9_uc003tdo.1_Missense_Mutation_p.L14V|BBS9_uc003tdp.1_Missense_Mutation_p.L14V|BBS9_uc003tdq.1_Missense_Mutation_p.L14V|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.L14V	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	14					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTCTACTATTCTGGGAGATAA	0.333									Bardet-Biedl_syndrome				0	0	0	0.009718	0	36	100										G	33185904	C	G	33185904	3	3	62	1	0	0	0	0	1	0	0	0	1342	912	32	1	42	1	BBS9	7	33185904	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3083617	33185904	125952759	192	18117										
ADCY1	107	broad.mit.edu	37	chr7	45743204	45743204	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctttgaacttccaggacctCtactaccagtcctactccca	4	17	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:45743204C>G	uc003tne.3	+	16	2595	c.2577C>G	c.(2575-2577)CTC>CTG	p.L859L		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	859	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCCAGGACCTCTACTACCAGT	0.582													0	0	0	0.003954	0	24	70										G	45743204	C	G	45743204	2	3	62	1	0	0	0	0	0	0	0	1	292	900	32	1		1	ADCY1	7	45743204	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	12557300	45743204	113395459	193	18118										
ZNF479	90827	broad.mit.edu	37	chr7	57188109	57188109	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcttatgtctagtaaggtttGaggaccagctaaaggctttg	11	6	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:57188109G>A	uc010kzo.2	-	5	1284	c.1013C>T	c.(1012-1014)TCA>TTA	p.S338L		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	338	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTAAGGTTTGAGGACCAGCT	0.453													0	0	0	0.004007	0	10	42										A	57188109	G	A	57188109	3	1	62	1	0	0	0	0	1	0	0	0	17930	1294	45	1	565	1	ZNF479	7	57188109	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	11444905	57188109	101950554	194	18119										
HGF	3082	broad.mit.edu	37	chr7	81346648	81346648	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttcggcagtaattctcattCagcttacttgcatctggttc	7	10	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:81346648C>G	uc003uhl.2	-	11	1470	c.1305G>C	c.(1303-1305)CTG>CTC	p.L435L	HGF_uc003uhm.2_Silent_p.L430L	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	435	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AATTCTCATTCAGCTTACTTG	0.438													0	0	0	0.01441	0	43	87										G	81346648	C	G	81346648	2	3	62	1	0	0	0	0	0	0	0	1	7085	813	29	1		1	HGF	7	81346648	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	24158539	81346648	77792015	195	18120										
PEX1	5189	broad.mit.edu	37	chr7	92143172	92143172	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttgaactcactaaattctctCtaggttgtaactttagagat	6	7	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:92143172C>G	uc003uly.2	-	6	1445	c.1349G>C	c.(1348-1350)AGA>ACA	p.R450T	PEX1_uc011khr.1_Missense_Mutation_p.R242T|PEX1_uc010ley.2_Missense_Mutation_p.R450T|PEX1_uc011khs.1_Missense_Mutation_p.R128T|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	450					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TAAATTCTCTCTAGGTTGTAA	0.328													0	0	0	0.013726	0	29	77										G	92143172	C	G	92143172	3	3	62	1	0	0	0	0	1	0	0	0	11735	913	32	1	2578	1	PEX1	7	92143172	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10796524	92143172	66995491	196	18121										
ZNF394	84124	broad.mit.edu	37	chr7	99091818	99091818	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcaaaaaggctggaatgatgGaaactgtctccactgtcaga	10	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:99091818G>T	uc003uqs.2	-	3	1181	c.1020C>A	c.(1018-1020)TTC>TTA	p.F340L	ZNF394_uc003uqt.2_Missense_Mutation_p.F133L	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	340					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGGAATGATGGAAACTGTCTC	0.483													1	0	9.78485e-24	0.013726	1.13186e-23	31	88										T	99091818	G	T	99091818	3	4	62	1	0	0	0	0	1	0	0	0	17877	1165	41	3	669	3	ZNF394	7	99091818	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	6948646	99091818	60046845	197	18122										
MUC17	140453	broad.mit.edu	37	chr7	100679360	100679360	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attctcaagccagttcatctCctacaactgctgacggtacc	6	14	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:100679360C>G	uc003uxp.1	+	3	4716	c.4663C>G	c.(4663-4665)CCT>GCT	p.P1555A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1555	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|24.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCTACAACTGC	0.493													0	0	0	0.01441	0	70	437										G	100679360	C	G	100679360	3	3	62	1	0	0	0	0	1	0	0	0	9974	855	30	1	4673	1	MUC17	7	100679360	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1587542	100679360	58459303	198	18123										
MUC17	140453	broad.mit.edu	37	chr7	100679868	100679868	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagcacacctgtgaccacttCtactgaagcccgttcatctc	6	16	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:100679868C>G	uc003uxp.1	+	3	5224	c.5171C>G	c.(5170-5172)TCT>TGT	p.S1724C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1724	Extracellular (Potential).|59 X approximate tandem repeats.|27.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGACCACTTCTACTGAAGCC	0.478													0	0	0	0.01441	0	79	512										G	100679868	C	G	100679868	3	3	62	1	0	0	0	0	1	0	0	0	9974	913	32	1	5181	1	MUC17	7	100679868	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	508	100679868	58458795	199	18124										
CUX1	1523	broad.mit.edu	37	chr7	101923386	101923386	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccagtacgaggagcgcctgGaccccttctcctccttcagc	9	18	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:101923386G>C	uc003uyt.2	+	19	1757	c.1738G>C	c.(1738-1740)GAC>CAC	p.D580H	CUX1_uc011kkn.1_Missense_Mutation_p.D541H|CUX1_uc003uyw.2_Missense_Mutation_p.D534H|CUX1_uc003uyv.2_Missense_Mutation_p.D564H|CUX1_uc003uyu.2_Missense_Mutation_p.D578H|CUX1_uc003uyz.2_RNA	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GGAGCGCCTGGACCCCTTCTC	0.662													0	0	0	0.004656	0	22	56										C	101923386	G	C	101923386	3	2	62	1	0	0	0	0	1	0	0	0	4064	1174	41	1	5182	1	CUX1	7	101923386	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1243518	101923386	57215277	200	18125										
KCND2	3751	broad.mit.edu	37	chr7	120385895	120385895	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	catggaagttgcaactgttaAtcgtccttcaagtcacagtc	8	10	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:120385895A>G	uc003vjj.1	+	5	2494	c.1529A>G	c.(1528-1530)AAT>AGT	p.N510S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	510	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCAACTGTTAATCGTCCTTCA	0.438													0	0	0	0.008361	0	27	51										G	120385895	A	G	120385895	3	3	62	1	0	0	0	0	1	0	0	0	8019	101	4	5	1547	5	KCND2	7	120385895	Missense_Mutation	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	18462509	120385895	38752768	201	18126										
TSGA13	114960	broad.mit.edu	37	chr7	130353957	130353957	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgggcatgtcttccaagagcGatgcgagtgtcagtggttcc	14	9	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:130353957G>T	uc003vqi.2	-	8	1182	c.725C>A	c.(724-726)TCG>TAG	p.S242*	COPG2_uc003vqh.1_5'Flank|TSGA13_uc003vqj.2_Nonsense_Mutation_p.S242*	NM_052933	NP_443165	Q96PP4	TSG13_HUMAN	testis specific, 13	242										ovary(2)	2	Melanoma(18;0.0435)					TTCCAAGAGCGATGCGAGTGT	0.582													1	0	3.86903e-22	0.013726	4.46662e-22	32	72										T	130353957	G	T	130353957	4	4	62	1	0	0	0	0	0	1	0	0	16616	1059	37	3	106	3	TSGA13	7	130353957	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	9968062	130353957	28784706	202	18127										
TBXAS1	6916	broad.mit.edu	37	chr7	139706905	139706905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	catcagatggcccctgagttCtgcagcctcgaggaaggcct	12	13	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:139706905C>G	uc011kqv.1	+	11	1454	c.1290C>G	c.(1288-1290)TTC>TTG	p.F430L	TBXAS1_uc003vvh.2_Missense_Mutation_p.F384L|TBXAS1_uc010lne.2_Missense_Mutation_p.F316L|TBXAS1_uc011kqu.1_Missense_Mutation_p.F335L|TBXAS1_uc003vvi.2_Missense_Mutation_p.F384L|TBXAS1_uc003vvj.2_Missense_Mutation_p.F384L|TBXAS1_uc011kqw.1_Missense_Mutation_p.F364L	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	383	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					CCCCTGAGTTCTGCAGCCTCG	0.532													0	0	0	0.01441	0	60	133										G	139706905	C	G	139706905	3	3	62	1	0	0	0	0	1	0	0	0	15661	912	32	1	1332	1	TBXAS1	7	139706905	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	9352948	139706905	19431758	203	18128										
OR2A25	392138	broad.mit.edu	37	chr7	143771967	143771967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccactgtaatatcttatgttCatattctatgtgccattcta	4	9	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:143771967C>T	uc011ktx.1	+	1	655	c.655C>T	c.(655-657)CAT>TAT	p.H219Y		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					ATCTTATGTTCATATTCTATG	0.483													0	0	0	0.003954	0	25	60										T	143771967	C	T	143771967	3	4	62	1	0	0	0	0	1	0	0	0	10978	826	29	1	657	1	OR2A25	7	143771967	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4065062	143771967	15366696	204	18129										
ZNF777	27153	broad.mit.edu	37	chr7	149129883	149129883	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcgccctcgggggacatctCcccgggcagcggggtctggt	16	15	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:149129883C>G	uc003wfv.2	-	6	1643	c.1480G>C	c.(1480-1482)GAG>CAG	p.E494Q		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGGGACATCTCCCCGGGCAGC	0.602													0	0	0	0.004482	0	7	27										G	149129883	C	G	149129883	3	3	62	1	0	0	0	0	1	0	0	0	18147	864	30	1	1019	1	ZNF777	7	149129883	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5357916	149129883	10008780	205	18130										
MLL3	58508	broad.mit.edu	37	chr7	151945439	151945439	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cactaaggtttctagtggaaGagtgacagattccatgacta	10	7	1	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:151945439G>A	uc003wla.2	-	14	2299	c.2080C>T	c.(2080-2082)CTT>TTT	p.L694F		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	694					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTAGTGGAAGAGTGACAGAT	0.423			N		medulloblastoma								0	0	0	0.000602	0	5	40										A	151945439	G	A	151945439	3	1	62	1	0	0	0	0	1	0	0	0	9622	942	33	1	12839	1	MLL3	7	151945439	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2815556	151945439	7193224	206	18131										
PAXIP1	22976	broad.mit.edu	37	chr7	154760267	154760269	+	In_Frame_Del	DEL	CTG	CTG	-													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcgctgtctgactttgcatCtgctgctgctgctgctgctg							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:154760267_154760269delCTG	uc003wlp.2	-	7	1685_1687	c.1642_1644delCAG	c.(1642-1644)CAGdel	p.Q548del	PAXIP1_uc003wlq.1_In_Frame_Del_p.Q514del|PAXIP1_uc011kvs.1_In_Frame_Del_p.Q512del|PAXIP1_uc003wlr.1_In_Frame_Del_p.Q457del	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	548	Gln-rich.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GACTTTGCATctgctgctgctgc	0.227																		4	4	---	---								-	154760269	CTG	-	154760267	7	5	62	1	0	1	0	1	0	0	0	0	11487	912	32	0	1625	0	PAXIP1	7	154760267	In_Frame_Del	DEL	CTG	TCGA-DK-A3IT-01A-31D-A20D-08	2814828	154760267	4378396	207	18132										
DOK2	9046	broad.mit.edu	37	chr8	21767094	21767094	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagagggtcggccaggagctGaggagggactgccaagatgc	18	9	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:21767094G>C	uc003wzy.1	-	5	1060	c.967C>G	c.(967-969)CAG>GAG	p.Q323E	DOK2_uc003wzx.1_Missense_Mutation_p.Q323E|DOK2_uc003wzz.1_Missense_Mutation_p.Q169E|DOK2_uc010lth.1_Missense_Mutation_p.Q169E	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	323	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GCCAGGAGCTGAGGAGGGACT	0.647													0	0	0	0.012213	0	30	43										C	21767094	G	C	21767094	3	2	62	1	0	0	0	0	1	0	0	0	4697	1299	45	1	275	1	DOK2	8	21767094	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		21767094	124596928	208	18133										
PEBP4	157310	broad.mit.edu	37	chr8	22570973	22570973	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttggtgagtcctggtagttCtgggtcatgaactgggtgct	16	6	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:22570973C>G	uc003xcn.1	-	7	686	c.594G>C	c.(592-594)CAG>CAC	p.Q198H		NM_144962	NP_659399	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	198						lysosome				ovary(1)|large_intestine(1)|breast(1)|skin(1)	4		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		CCTGGTAGTTCTGGGTCATGA	0.557													0	0	0	0.00308	0	8	18										G	22570973	C	G	22570973	3	3	62	1	0	0	0	0	1	0	0	0	11714	912	32	1	93	1	PEBP4	8	22570973	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	803879	22570973	123793049	209	18134										
PUF60	22827	broad.mit.edu	37	chr8	144899273	144899273	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggggttcaccactcccaccGaggggatggtgaccgggata	15	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144899273G>A	uc003yzs.2	-	11	1251	c.1187C>T	c.(1186-1188)TCG>TTG	p.S396L	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Missense_Mutation_p.S336L|PUF60_uc003yzt.2_Missense_Mutation_p.S379L|PUF60_uc003yzq.2_Missense_Mutation_p.S353L|PUF60_uc003yzu.1_Missense_Mutation_p.S385L	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	396	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CACTCCCACCGAGGGGATGGT	0.612													0	0	0	0.00308	0	5	32										A	144899273	G	A	144899273	3	1	62	1	0	0	0	0	1	0	0	0	12824	1059	37	1	500	1	PUF60	8	144899273	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	122328300	144899273	1464749	210	18135										
NRBP2	340371	broad.mit.edu	37	chr8	144921499	144921499	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccagcaccggagccgatcttGatgaggccgttgtgctgaat	13	11	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144921499G>C	uc011lkt.1	-	6	707	c.567C>G	c.(565-567)ATC>ATG	p.I189M	NRBP2_uc003yzv.2_Translation_Start_Site|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_Translation_Start_Site|NRBP2_uc011lks.1_Translation_Start_Site|NRBP2_uc003yzy.2_Translation_Start_Site	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	189	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGCCGATCTTGATGAGGCCGT	0.657													0	0	0	0.009096	0	3	28										C	144921499	G	C	144921499	3	2	62	1	0	0	0	0	1	0	0	0	10643	1280	45	1	990	1	NRBP2	8	144921499	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	22226	144921499	1442523	211	18136										
PLEC	5339	broad.mit.edu	37	chr8	144999683	144999683	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagtgcctgcagctccccctCagccccgccacgctggcgct	10	21	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144999683C>T	uc003zaf.1	-	31	4995	c.4825G>A	c.(4825-4827)GAG>AAG	p.E1609K	PLEC_uc003zab.1_Missense_Mutation_p.E1472K|PLEC_uc003zac.1_Missense_Mutation_p.E1476K|PLEC_uc003zad.2_Missense_Mutation_p.E1472K|PLEC_uc003zae.1_Missense_Mutation_p.E1440K|PLEC_uc003zag.1_Missense_Mutation_p.E1450K|PLEC_uc003zah.2_Missense_Mutation_p.E1458K|PLEC_uc003zaj.2_Missense_Mutation_p.E1499K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1609	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCTCCCCCTCAGCCCCGCCA	0.721													0	0	0	0.001168	0	5	25										T	144999683	C	T	144999683	3	4	62	1	0	0	0	0	1	0	0	0	12052	835	29	1	9237	1	PLEC	8	144999683	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	78184	144999683	1364339	212	18137										
HSF1	3297	broad.mit.edu	37	chr8	145533476	145533476	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aggtgtccaccctgaagagtGaagacataaagatccgccag	11	10	0	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:145533476G>A	uc003zbt.3	+	4	552	c.382G>A	c.(382-384)GAA>AAA	p.E128K	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	128						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCTGAAGAGTGAAGACATAAA	0.602													0	0	0	0.00278	0	16	152										A	145533476	G	A	145533476	3	1	62	1	0	0	0	0	1	0	0	0	7395	1291	45	1	396	1	HSF1	8	145533476	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	533793	145533476	830546	213	18138										
GLDC	2731	broad.mit.edu	37	chr9	6540106	6540106	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcaatatttgcagactttttGaagggtctcgtgtccaaaat	8	7	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:6540106G>C	uc003zkc.2	-	22	2803	c.2610C>G	c.(2608-2610)TTC>TTG	p.F870L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	870					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGACTTTTTGAAGGGTCTCG	0.448													0	0	0	0.010504	0	19	90										C	6540106	G	C	6540106	3	2	62	1	0	0	0	0	1	0	0	0	6433	1281	45	1	468	1	GLDC	9	6540106	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		6540106	134673325	214	18139										
C9orf93	203238	broad.mit.edu	37	chr9	15623317	15623317	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaaagtagaaaaattagaaaCagaacatatggactgctctg	9	5	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:15623317C>G	uc003zmd.2	+	7	1043	c.728C>G	c.(727-729)ACA>AGA	p.T243R	C9orf93_uc010mih.1_Missense_Mutation_p.T243R|C9orf93_uc003zme.2_Missense_Mutation_p.T150R|C9orf93_uc011lmu.1_Missense_Mutation_p.T243R|C9orf93_uc003zmc.2_Missense_Mutation_p.T243R	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	243	Potential.|Glu-rich.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		AAATTAGAAACAGAACATATG	0.348													0	0	0	0.006122	0	15	72										G	15623317	C	G	15623317	3	3	62	1	0	0	0	0	1	0	0	0	2506	478	17	4	750	4	C9orf93	9	15623317	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	9083211	15623317	125590114	215	18140										
SLC24A2	25769	broad.mit.edu	37	chr9	19521029	19521029	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aagatggtcaggcccataatCtcttcactgatgccaattgt	8	10	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:19521029C>G	uc003zoa.1	-	9	1661	c.1599G>C	c.(1597-1599)GAG>GAC	p.E533D	SLC24A2_uc003zob.1_Missense_Mutation_p.E516D	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	533	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCCCATAATCTCTTCACTGA	0.448													0	0	0	0.007413	0	14	17										G	19521029	C	G	19521029	3	3	62	1	0	0	0	0	1	0	0	0	14466	912	32	1	394	1	SLC24A2	9	19521029	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3897712	19521029	121692402	216	18141										
ALDH1A1	216	broad.mit.edu	37	chr9	75540481	75540481	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	accactgtgtttccacagctCagtgcaggccctatcttcca	7	15	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:75540481C>G	uc004ajd.2	-	6	605	c.552G>C	c.(550-552)CTG>CTC	p.L184L	ALDH1A1_uc011lsh.1_Silent_p.L105L|ALDH1A1_uc011lsg.1_Silent_p.L10L	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	184					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTCCACAGCTCAGTGCAGGCC	0.423													0	0	0	0.004656	0	24	30										G	75540481	C	G	75540481	2	3	62	1	0	0	0	0	0	0	0	1	490	813	29	1		1	ALDH1A1	9	75540481	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	56019452	75540481	65672950	217	18142										
PRUNE2	158471	broad.mit.edu	37	chr9	79318656	79318656	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctggtcttgtgcagggctttCaaaagatgatctcgtatcgc	11	9	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:79318656C>T	uc010mpk.2	-	9	7997	c.7873G>A	c.(7873-7875)GAA>AAA	p.E2625K	PRUNE2_uc004akj.3_Missense_Mutation_p.E78K|PRUNE2_uc010mpl.1_Missense_Mutation_p.E78K	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2625					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GCAGGGCTTTCAAAAGATGAT	0.493													0	0	0	0.004672	0	3	9										T	79318656	C	T	79318656	3	4	62	1	0	0	0	0	1	0	0	0	12641	835	29	1	1437	1	PRUNE2	9	79318656	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3778175	79318656	61894775	218	18143										
S1PR3	1903	broad.mit.edu	37	chr9	91617099	91617099	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggggcccgcgcctcacccatCcagcctgcgctcgacccaag	11	20	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:91617099C>T	uc004aqe.2	+	2	1380	c.984C>T	c.(982-984)ATC>ATT	p.I328I		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	328	Cytoplasmic (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						CCTCACCCATCCAGCCTGCGC	0.627													0	0	0	0.012319	0	18	27										T	91617099	C	T	91617099	2	4	62	1	0	0	0	0	0	0	0	1	13795	845	30	1		1	S1PR3	9	91617099	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	12298443	91617099	49596332	219	18144										
FAM129B	64855	broad.mit.edu	37	chr9	130269539	130269539	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcttttccgagagggtggctGactccggggtgctggggctg	19	9	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:130269539G>A	uc004brh.2	-	14	2028	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L	FAM129B_uc004bri.2_Missense_Mutation_p.S596L|FAM129B_uc004brj.3_3'UTR	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	609							protein binding				0						GAGGGTGGCTGACTCCGGGGT	0.697													0	0	0	0.006122	0	15	12										A	130269539	G	A	130269539	3	1	62	1	0	0	0	0	1	0	0	0	5437	1294	45	1	418	1	FAM129B	9	130269539	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	38652440	130269539	10943892	220	18145										
GOLGA2	2801	broad.mit.edu	37	chr9	131028091	131028091	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttctgcctggcagcatgctGagtgtgagccagggctgtct	14	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:131028091G>A	uc011maw.1	-	10	734	c.721C>T	c.(721-723)CAG>TAG	p.Q241*	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004bul.1_Nonsense_Mutation_p.Q142*|GOLGA2_uc004bum.1_Nonsense_Mutation_p.Q115*	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	241	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						GCAGCATGCTGAGTGTGAGCC	0.532													0	0	0	0.007291	0	22	54										A	131028091	G	A	131028091	4	1	62	1	0	0	0	0	0	1	0	0	6552	1299	45	1	2355	1	GOLGA2	9	131028091	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	758552	131028091	10185340	221	18146										
KCNT1	57582	broad.mit.edu	37	chr9	138650273	138650273	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tccacagaatgacttccaccGtgccatcctgcggacacagt	8	15	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:138650273G>A	uc011mdq.1	+	10	847	c.773G>A	c.(772-774)CGT>CAT	p.R258H	KCNT1_uc011mdr.1_Missense_Mutation_p.R85H|KCNT1_uc010nbf.2_Missense_Mutation_p.R210H|KCNT1_uc004cgo.1_Missense_Mutation_p.R7H	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	258						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GACTTCCACCGTGCCATCCTG	0.587													0	0	0	0.014323	0	17	81										A	138650273	G	A	138650273	3	1	62	1	0	0	0	0	1	0	0	0	8091	1145	40	2	811	2	KCNT1	9	138650273	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	7622182	138650273	2563158	222	18147										
INPP5E	56623	broad.mit.edu	37	chr9	139326391	139326391	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccgccactcaggcggaagttGaagtctccaaaccagaacac	9	14	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:139326391G>A	uc004cho.2	-	7	1819	c.1434C>T	c.(1432-1434)TTC>TTT	p.F478F	INPP5E_uc010nbm.2_Silent_p.F477F	NM_019892	NP_063945	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase E	478						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			skin(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GGCGGAAGTTGAAGTCTCCAA	0.667													0	0	0	0.008361	0	22	23										A	139326391	G	A	139326391	2	1	62	1	0	0	0	0	0	0	0	1	7757	1281	45	1		1	INPP5E	9	139326391	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	676118	139326391	1887040	223	18148										
GRIN1	2902	broad.mit.edu	37	chr9	140051206	140051206	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtggctggtcggcgagcgcGagatctcggggaacgccctg	18	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140051206G>A	uc004clk.2	+	5	1087	c.757G>A	c.(757-759)GAG>AAG	p.E253K	GRIN1_uc004cli.1_5'UTR|GRIN1_uc004clj.1_Missense_Mutation_p.E250K|GRIN1_uc004cll.2_Missense_Mutation_p.E253K|GRIN1_uc004clm.2_Missense_Mutation_p.E253K|GRIN1_uc004cln.2_Missense_Mutation_p.E271K|GRIN1_uc004clo.2_Missense_Mutation_p.E271K	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	253	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGCGAGCGCGAGATCTCGGG	0.697													0	0	0	0.001984	0	6	3										A	140051206	G	A	140051206	3	1	62	1	0	0	0	0	1	0	0	0	6778	1059	37	1	842	1	GRIN1	9	140051206	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	724815	140051206	1162225	224	18149										
GRIN1	2902	broad.mit.edu	37	chr9	140051368	140051368	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acgagtcggcccacatcagcGacgccgtgggcgtggtggcc	16	14	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140051368G>A	uc004clk.2	+	6	1177	c.847G>A	c.(847-849)GAC>AAC	p.D283N	GRIN1_uc004cli.1_5'UTR|GRIN1_uc004clj.1_Missense_Mutation_p.D280N|GRIN1_uc004cll.2_Missense_Mutation_p.D283N|GRIN1_uc004clm.2_Missense_Mutation_p.D283N|GRIN1_uc004cln.2_Missense_Mutation_p.D301N|GRIN1_uc004clo.2_Missense_Mutation_p.D301N	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	283	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCACATCAGCGACGCCGTGGG	0.672													0	0	0	0.00308	0	7	3										A	140051368	G	A	140051368	3	1	62	1	0	0	0	0	1	0	0	0	6778	1058	37	1	936	1	GRIN1	9	140051368	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	162	140051368	1162063	225	18150										
MRPL41	64975	broad.mit.edu	37	chr9	140446562	140446562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctggccgcagcggcgcgctGcctggtccggggtgcggacc	18	16	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140446562G>A	uc004cnh.3	+	2	159	c.29G>A	c.(28-30)TGC>TAC	p.C10Y	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	10					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GCGGCGCGCTGCCTGGTCCGG	0.657													0	0	0	0.006214	0	7	9										A	140446562	G	A	140446562	3	1	62	1	0	0	0	0	1	0	0	0	9805	1319	46	2	31	2	MRPL41	9	140446562	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	395194	140446562	766869	226	18151										
EHMT1	79813	broad.mit.edu	37	chr9	140729270	140729270	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gacatcaaaggcaagctcttCagctgccgctgcggctcccc	10	16	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140729270C>T	uc011mfc.1	+	27	3799	c.3762C>T	c.(3760-3762)TTC>TTT	p.F1254F	EHMT1_uc004coe.2_Silent_p.F159F	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1254					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCAAGCTCTTCAGCTGCCGCT	0.672													0	0	0	0.00499	0	14	16										T	140729270	C	T	140729270	2	4	62	1	0	0	0	0	0	0	0	1	4983	825	29	1		1	EHMT1	9	140729270	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	282708	140729270	484161	227	18152										
ANKRD16	54522	broad.mit.edu	37	chr10	5925115	5925115	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgggcacccaggctgtcttCtgctgaaaggcaagcctagt	12	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:5925115C>T	uc010qat.1	-	5	1246	c.703G>A	c.(703-705)GAA>AAA	p.E235K	ANKRD16_uc009xie.2_Missense_Mutation_p.E235K|ANKRD16_uc009xif.2_Missense_Mutation_p.E235K|ANKRD16_uc001iiq.2_Missense_Mutation_p.E235K	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	235											0						AGGCTGTCTTCTGCTGAAAGG	0.542													0	0	0	0.006214	0	6	31										T	5925115	C	T	5925115	3	4	62	1	0	0	0	0	1	0	0	0	645	922	32	1	394	1	ANKRD16	10	5925115	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		5925115	129609632	228	18153										
FBXO18	84893	broad.mit.edu	37	chr10	5945065	5945065	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttggctgtgacccagcccttCggtcaaagatggacaaacag	11	11	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:5945065C>A	uc001iis.2	+	2	179	c.84C>A	c.(82-84)TTC>TTA	p.F28L	FBXO18_uc001iir.2_5'UTR|FBXO18_uc009xig.2_5'UTR|FBXO18_uc001iit.2_Missense_Mutation_p.F79L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	28					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCCAGCCCTTCGGTCAAAGAT	0.488													1	0	1.99505e-19	0.012213	2.28062e-19	26	40										A	5945065	C	A	5945065	3	1	62	1	0	0	0	0	1	0	0	0	5731	883	31	3	252	3	FBXO18	10	5945065	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	19950	5945065	129589682	229	18154										
TRDMT1	1787	broad.mit.edu	37	chr10	17195630	17195630	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtaagggatttgtagatattCtcaacctgtaagaaaatacc	8	6	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:17195630C>G	uc001iop.2	-	10	999	c.951G>C	c.(949-951)GAG>GAC	p.E317D	TRDMT1_uc001ioq.2_Missense_Mutation_p.E293D|TRDMT1_uc001ior.2_Missense_Mutation_p.E271D|TRDMT1_uc001ios.2_Missense_Mutation_p.E246D|TRDMT1_uc009xjt.2_Missense_Mutation_p.E236D|TRDMT1_uc010qcc.1_Missense_Mutation_p.E246D|TRDMT1_uc010qcd.1_Missense_Mutation_p.E194D	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	317					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						TGTAGATATTCTCAACCTGTA	0.333													0	0	0	0.001168	0	4	18										G	17195630	C	G	17195630	3	3	62	1	0	0	0	0	1	0	0	0	16464	912	32	1	232	1	TRDMT1	10	17195630	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	11250565	17195630	118339117	230	18155										
MLLT10	8028	broad.mit.edu	37	chr10	21962735	21962735	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttctgcttcaccaacatcatCtgtagcatcagctgcaggaa	7	12	5	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:21962735C>G	uc001iqs.2	+	11	1856	c.1508C>G	c.(1507-1509)TCT>TGT	p.S503C	MLLT10_uc001iqt.2_Missense_Mutation_p.S503C|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.S503C|MLLT10_uc001ira.2_Translation_Start_Site|MLLT10_uc001irb.2_RNA|MLLT10_uc001iqz.2_Missense_Mutation_p.S258C	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	503	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						CCAACATCATCTGTAGCATCA	0.433			T	MLL|PICALM|CDK6	AL								0	0	0	0.008361	0	27	76										G	21962735	C	G	21962735	3	3	62	1	0	0	0	0	1	0	0	0	9626	913	32	1	1546	1	MLLT10	10	21962735	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4767105	21962735	113572012	231	18156										
RBP3	5949	broad.mit.edu	37	chr10	48389845	48389845	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagcagggtgggcacacggtCcaccagcgtgtagtagtcct	14	12	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:48389845C>T	uc001jez.2	-	1	1147	c.1033G>A	c.(1033-1035)GAC>AAC	p.D345N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	345	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGCACACGGTCCACCAGCGTG	0.637													0	0	0	0.010729	0	11	53										T	48389845	C	T	48389845	3	4	62	1	0	0	0	0	1	0	0	0	13157	855	30	1	2726	1	RBP3	10	48389845	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	26427110	48389845	87144902	232	18157										
OGDHL	55753	broad.mit.edu	37	chr10	50966537	50966537	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggaaggtggccggtggcccGgaggacctgctgcgccagcc	19	13	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:50966537G>A	uc001jie.2	-	2	244	c.102C>T	c.(100-102)TCC>TCT	p.S34S	OGDHL_uc009xog.2_Silent_p.S61S|OGDHL_uc010qgt.1_Silent_p.S34S|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	34					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CCGGTGGCCCGGAGGACCTGC	0.632													0	0	0	0.007413	0	17	27										A	50966537	G	A	50966537	2	1	62	1	0	0	0	0	0	0	0	1	10840	1103	39	2		2	OGDHL	10	50966537	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2576692	50966537	84568210	233	18158										
LRRTM3	347731	broad.mit.edu	37	chr10	68687370	68687370	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccaaggttggtcagccttcaGaacctttacttgcagtggaa	10	10	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:68687370G>A	uc001jmz.1	+	2	1246	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.Q232Q	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	232	Extracellular (Potential).|LRR 8.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TCAGCCTTCAGAACCTTTACT	0.453													0	0	0	0.003271	0	31	69										A	68687370	G	A	68687370	2	1	62	1	0	0	0	0	0	0	0	1	9041	933	33	1		1	LRRTM3	10	68687370	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	17720833	68687370	66847377	234	18159										
KIAA1274	27143	broad.mit.edu	37	chr10	72324122	72324122	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccctgtcctgtcctccaggcGaaggcagcgaaagaggcgca	13	14	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:72324122G>A	uc001jrd.3	+	19	2546	c.2265G>A	c.(2263-2265)GCG>GCA	p.A755A	KIAA1274_uc001jre.3_Silent_p.A46A	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	755										ovary(2)|central_nervous_system(1)	3						TCCTCCAGGCGAAGGCAGCGA	0.617													0	0	0	0.004878	0	30	56										A	72324122	G	A	72324122	2	1	62	1	0	0	0	0	0	0	0	1	8220	1045	37	1		1	KIAA1274	10	72324122	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3636752	72324122	63210625	235	18160										
SLC29A3	55315	broad.mit.edu	37	chr10	73111520	73111520	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atgaccggctcctttcctatGaggaactcccaggcactgat	9	13	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:73111520G>C	uc001jrr.3	+	4	642	c.585G>C	c.(583-585)ATG>ATC	p.M195I	SLC29A3_uc001jrs.3_Missense_Mutation_p.M195I|SLC29A3_uc010qjq.1_Missense_Mutation_p.M49I|SLC29A3_uc001jrt.3_Intron|SLC29A3_uc001jru.3_Missense_Mutation_p.M7I	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	195	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CCTTTCCTATGAGGAACTCCC	0.577													0	0	0	0.00245	0	10	17										C	73111520	G	C	73111520	3	2	62	1	0	0	0	0	1	0	0	0	14536	1290	45	1	599	1	SLC29A3	10	73111520	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	787398	73111520	62423227	236	18161										
CDH23	64072	broad.mit.edu	37	chr10	73464806	73464806	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccgagctggaccgcgagcgcAtcgcggagtaccagctgcgg	16	14	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:73464806A>G	uc001jrx.3	+	24	3249	c.2872A>G	c.(2872-2874)ATC>GTC	p.I958V	CDH23_uc001jry.2_Missense_Mutation_p.I574V|CDH23_uc001jrz.2_Missense_Mutation_p.I574V	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	958	Cadherin 9.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCGCGAGCGCATCGCGGAGTA	0.677													0	0	0	0.014323	0	18	41										G	73464806	A	G	73464806	3	3	62	1	0	0	0	0	1	0	0	0	3108	217	8	5	3193	5	CDH23	10	73464806	Missense_Mutation	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	353286	73464806	62069941	237	18162										
HPSE2	60495	broad.mit.edu	37	chr10	100249921	100249921	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccaagactttggggccgatCaggcgcttgtagaggagaga	16	8	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:100249921C>G	uc001kpn.1	-	10	1413	c.1353G>C	c.(1351-1353)CTG>CTC	p.L451L	HPSE2_uc009xwc.1_Silent_p.L441L|HPSE2_uc001kpo.1_Silent_p.L383L|HPSE2_uc009xwd.1_Silent_p.L329L	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	451					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TGGGGCCGATCAGGCGCTTGT	0.552													0	0	0	0.01441	0	42	67										G	100249921	C	G	100249921	2	3	62	1	0	0	0	0	0	0	0	1	7345	813	29	1		1	HPSE2	10	100249921	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	26785115	100249921	35284826	238	18163										
MGEA5	10724	broad.mit.edu	37	chr10	103567511	103567511	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggacagaagaggaaagtttCtggctctcctaggtactgat	13	7	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103567511C>T	uc001ktv.2	-	5	1071	c.628G>A	c.(628-630)GAA>AAA	p.E210K	MGEA5_uc010qqe.1_Missense_Mutation_p.E210K|MGEA5_uc009xws.2_Missense_Mutation_p.E210K|MGEA5_uc001ktw.2_Missense_Mutation_p.E210K|MGEA5_uc009xwt.2_Missense_Mutation_p.E68K|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	210					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		AGGAAAGTTTCTGGCTCTCCT	0.393													0	0	0	0.012319	0	18	114										T	103567511	C	T	103567511	3	4	62	1	0	0	0	0	1	0	0	0	9555	922	32	1	2170	1	MGEA5	10	103567511	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3317590	103567511	31967236	239	18164										
PPRC1	23082	broad.mit.edu	37	chr10	103906708	103906708	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cattccagaggtgggctcccGatggaatgtcaagcgccatc	12	12	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103906708G>C	uc001kum.2	+	9	3998	c.3959G>C	c.(3958-3960)CGA>CCA	p.R1320P	PPRC1_uc001kun.2_Missense_Mutation_p.R1200P|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTGGGCTCCCGATGGAATGTC	0.607													0	0	0	0.010729	0	11	42										C	103906708	G	C	103906708	3	2	62	1	0	0	0	0	1	0	0	0	12410	1058	37	1	3993	1	PPRC1	10	103906708	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	339197	103906708	31628039	240	18165										
PPRC1	23082	broad.mit.edu	37	chr10	103908426	103908426	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgaccattaccaaaggcaaaGagtgctacaaaaggagcgtg	11	8	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103908426G>C	uc001kum.2	+	11	4631	c.4592G>C	c.(4591-4593)AGA>ACA	p.R1531T	PPRC1_uc001kun.2_Missense_Mutation_p.R1409T|PPRC1_uc010qqj.1_Missense_Mutation_p.R1267T|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1531	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CAAAGGCAAAGAGTGCTACAA	0.493													0	0	0	0.01441	0	41	104										C	103908426	G	C	103908426	3	2	62	1	0	0	0	0	1	0	0	0	12410	942	33	1	4634	1	PPRC1	10	103908426	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1718	103908426	31626321	241	18166										
PPRC1	23082	broad.mit.edu	37	chr10	103909067	103909067	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggccgaaggcagttctgcaaGaggagctattctgatcttgg	14	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103909067G>C	uc001kum.2	+	13	4911	c.4872G>C	c.(4870-4872)AAG>AAC	p.K1624N	PPRC1_uc001kun.2_Missense_Mutation_p.K1502N|PPRC1_uc010qqj.1_Missense_Mutation_p.K1360N|PPRC1_uc009xxa.2_RNA|NOLC1_uc001kuo.2_5'Flank|NOLC1_uc001kup.2_5'Flank|NOLC1_uc001kuq.2_5'Flank|NOLC1_uc009xxb.1_5'Flank|NOLC1_uc001kur.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1624					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTTCTGCAAGAGGAGCTATT	0.557													0	0	0	0.008361	0	28	65										C	103909067	G	C	103909067	3	2	62	1	0	0	0	0	1	0	0	0	12410	933	33	1	4922	1	PPRC1	10	103909067	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	641	103909067	31625680	242	18167										
CALHM2	51063	broad.mit.edu	37	chr10	105207266	105207266	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtggtgagcagtaatgcttGaggcacttggtcaggaacac	14	7	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:105207266G>C	uc001kwz.2	-	3	1001	c.615C>G	c.(613-615)CTC>CTG	p.L205L	CALHM2_uc001kxa.2_Silent_p.L205L|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Silent_p.L205L	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	205	Helical; (Potential).					integral to membrane				skin(1)	1						AGTAATGCTTGAGGCACTTGG	0.617													0	0	0	0.009096	0	3	38										C	105207266	G	C	105207266	2	2	62	1	0	0	0	0	0	0	0	1	2583	1277	45	1		1	CALHM2	10	105207266	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1298199	105207266	30327481	243	18168										
COL17A1	1308	broad.mit.edu	37	chr10	105819447	105819447	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attgtaggcagcttgcttttCtttttttagggtgtcttctg	10	6	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:105819447C>G	uc001kxr.2	-	15	1340	c.1171G>C	c.(1171-1173)GAA>CAA	p.E391Q	COL17A1_uc010qqv.1_Missense_Mutation_p.E375Q	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	391	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GCTTGCTTTTCTTTTTTTAGG	0.438													0	0	0	0.014323	0	19	38										G	105819447	C	G	105819447	3	3	62	1	0	0	0	0	1	0	0	0	3674	922	32	1	3490	1	COL17A1	10	105819447	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	612181	105819447	29715300	244	18169										
SORCS3	22986	broad.mit.edu	37	chr10	107007054	107007054	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acattcctgagtggagaaaaGatattggcaatgtcatcaag	10	6	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:107007054G>C	uc001kyi.1	+	22	3297	c.3070G>C	c.(3070-3072)GAT>CAT	p.D1024H	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1024	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GTGGAGAAAAGATATTGGCAA	0.383													0	0	0	0.009535	0	24	46										C	107007054	G	C	107007054	3	2	62	1	0	0	0	0	1	0	0	0	14932	942	33	1	3156	1	SORCS3	10	107007054	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1187607	107007054	28527693	245	18170										
FOXI2	399823	broad.mit.edu	37	chr10	129537070	129537070	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcaccttccccgggggcctGgcgggcgacttttctttcgg	15	14	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:129537070G>A	uc009yas.2	+	2	798	c.798G>A	c.(796-798)CTG>CTA	p.L266L	uc009yar.1_5'Flank	NM_207426	NP_997309	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	266					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				CCGGGGGCCTGGCGGGCGACT	0.701													0	0	0	0.001168	0	4	3										A	129537070	G	A	129537070	2	1	62	1	0	0	0	0	0	0	0	1	6010	1335	47	2		2	FOXI2	10	129537070	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	22530016	129537070	5997677	246	18171										
INPP5A	3632	broad.mit.edu	37	chr10	134459392	134459392	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtcgtgcacacacacaagccGcacttcatggccttgcactg	9	15	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:134459392G>A	uc001llp.2	+	3	386	c.138G>A	c.(136-138)CCG>CCA	p.P46P	INPP5A_uc001llo.1_Silent_p.P46P|INPP5A_uc001llq.2_5'UTR	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	46					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CACACAAGCCGCACTTCATGG	0.612													0	0	0	0.007291	0	20	34										A	134459392	G	A	134459392	2	1	62	1	0	0	0	0	0	0	0	1	7754	1074	38	2		2	INPP5A	10	134459392	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4922322	134459392	1075355	247	18172										
MUC6	4588	broad.mit.edu	37	chr11	1028937	1028937	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tccgttgttggtgaccacctCgtcctgagagatcacaattt	9	11	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:1028937C>T	uc001lsw.2	-	12	1456	c.1405G>A	c.(1405-1407)GAG>AAG	p.E469K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	469	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGACCACCTCGTCCTGAGAG	0.627													0	0	0	0.013114	0	33	49										T	1028937	C	T	1028937	3	4	62	1	0	0	0	0	1	0	0	0	9980	893	31	1	6002	1	MUC6	11	1028937	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		1028937	133977579	248	18173										
HIPK3	10114	broad.mit.edu	37	chr11	33370177	33370177	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtatagaaacacaggacaatCagaactcagaaggagaggca	11	7	2	4	rs150770633		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:33370177C>T	uc001mul.1	+	13	2749	c.2479C>T	c.(2479-2481)CAG>TAG	p.Q827*	HIPK3_uc001mum.1_Nonsense_Mutation_p.Q806*|HIPK3_uc009yjv.1_Nonsense_Mutation_p.Q806*	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	827	Interaction with FAS (By similarity).|Interaction with AR (By similarity).				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						ACAGGACAATCAGAACTCAGA	0.378													0	0	0	0.00623	0	36	42										T	33370177	C	T	33370177	4	4	62	1	0	0	0	0	0	1	0	0	7118	827	29	1	2525	1	HIPK3	11	33370177	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	32341240	33370177	101636339	249	18174										
OR5M8	219484	broad.mit.edu	37	chr11	56258214	56258214	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aggtaggaaatacatatgatGaagagagaaaaagaaaggtt	12	1	0	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:56258214G>A	uc001nix.1	-	1	633	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TACATATGATGAAGAGAGAAA	0.433													0	0	0	0.004482	0	8	69										A	56258214	G	A	56258214	2	1	62	1	0	0	0	0	0	0	0	1	11176	1281	45	1		1	OR5M8	11	56258214	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	22888037	56258214	78748302	250	18175										
GLYATL1	92292	broad.mit.edu	37	chr11	58711103	58711103	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggtacctgcaggatccaattGtgtccattgatctctcagag	10	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:58711103G>A	uc001nnf.2	+	3	298	c.-78G>A	c.(-80--76)TTGTG>TTATG		uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.V38M|GLYATL1_uc001nni.1_Translation_Start_Site|GLYATL1_uc001nnj.1_Translation_Start_Site			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;							mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	ggatccaattgtgtccattga	0													0	0	0	0.010729	0	9	56										A	58711103	G	A	58711103	1	1	62	1	0	0	0	0	0	0	0	0	6480	1377	48	2		2	GLYATL1	11	58711103	Translation_Start_Site	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2452889	58711103	76295413	251	18176										
TCN1	6947	broad.mit.edu	37	chr11	59623355	59623355	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttatacctgaagcagagacGcaagaagagtctttgttaat	9	7	1	4	rs146250932	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:59623355G>C	uc001noj.2	-	6	1022	c.924C>G	c.(922-924)TGC>TGG	p.C308W		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	308					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGCAGAGACGCAAGAAGAGT	0.443													0	0	0	0.004656	0	20	66										C	59623355	G	C	59623355	3	2	62	1	0	0	0	0	1	0	0	0	15703	1079	38	4	393	4	TCN1	11	59623355	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	912252	59623355	75383161	252	18177										
EML3	256364	broad.mit.edu	37	chr11	62378418	62378418	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttcctggagagcttctgccGaggccgctctgagggggatg	16	11	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62378418G>A	uc001ntu.1	-	4	807	c.499C>T	c.(499-501)CGG>TGG	p.R167W	EML3_uc001ntr.1_Missense_Mutation_p.R139W|EML3_uc001nts.1_Missense_Mutation_p.R139W|EML3_uc001ntt.1_Missense_Mutation_p.R51W|EML3_uc010rly.1_Missense_Mutation_p.R167W|EML3_uc009yny.1_5'UTR|ROM1_uc001ntv.2_5'Flank	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	167						cytoplasm|microtubule	protein binding			ovary(1)	1						AGCTTCTGCCGAGGCCGCTCT	0.612													0	0	0	0.003163	0	12	74										A	62378418	G	A	62378418	3	1	62	1	0	0	0	0	1	0	0	0	5098	1057	37	1	2267	1	EML3	11	62378418	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2755063	62378418	72628098	253	18178										
GANAB	23193	broad.mit.edu	37	chr11	62398090	62398090	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	taccttccgcctcttagaagCcaagcgctcaagcatggtgc	9	14	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62398090C>G	uc001nub.2	-	11	1402	c.1369G>C	c.(1369-1371)GCT>CCT	p.A457P	GANAB_uc001nua.2_Missense_Mutation_p.A479P|GANAB_uc001nuc.2_Missense_Mutation_p.A360P|GANAB_uc010rma.1_Missense_Mutation_p.A365P|GANAB_uc010rmb.1_Missense_Mutation_p.A343P	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	457					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CTCTTAGAAGCCAAGCGCTCA	0.537													0	0	0	0.009096	0	4	45										G	62398090	C	G	62398090	3	3	62	1	0	0	0	0	1	0	0	0	6233	739	26	4	1521	4	GANAB	11	62398090	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	19672	62398090	72608426	254	18179										
GANAB	23193	broad.mit.edu	37	chr11	62398117	62398117	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcaagcatggtgcggggctGagggaagcgactggggtccc	18	10	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62398117G>A	uc001nub.2	-	11	1375	c.1342C>T	c.(1342-1344)CAG>TAG	p.Q448*	GANAB_uc001nua.2_Nonsense_Mutation_p.Q470*|GANAB_uc001nuc.2_Nonsense_Mutation_p.Q351*|GANAB_uc010rma.1_Nonsense_Mutation_p.Q356*|GANAB_uc010rmb.1_Nonsense_Mutation_p.Q334*	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	448					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GTGCGGGGCTGAGGGAAGCGA	0.547													0	0	0	0.001855	0	11	58										A	62398117	G	A	62398117	4	1	62	1	0	0	0	0	0	1	0	0	6233	1299	45	1	1548	1	GANAB	11	62398117	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	27	62398117	72608399	255	18180										
INTS5	80789	broad.mit.edu	37	chr11	62416959	62416959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcagctaccaatgagagccGagaggcactgcacatagatg	13	10	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62416959G>A	uc001nud.2	-	2	646	c.593C>T	c.(592-594)TCG>TTG	p.S198L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	198					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AATGAGAGCCGAGAGGCACTG	0.532													0	0	0	0.003755	0	31	102										A	62416959	G	A	62416959	3	1	62	1	0	0	0	0	1	0	0	0	7781	1059	37	1	2470	1	INTS5	11	62416959	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	18842	62416959	72589557	256	18181										
CDCA5	113130	broad.mit.edu	37	chr11	64846584	64846584	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	accccccactgcatctcattCaaccaggagatcaaactgct	5	16	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:64846584C>G	uc001ocp.2	-	6	919	c.754G>C	c.(754-756)GAA>CAA	p.E252Q		NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	252					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						GCATCTCATTCAACCAGGAGA	0.572													0	0	0	0.010504	0	14	29										G	64846584	C	G	64846584	3	3	62	1	0	0	0	0	1	0	0	0	3089	835	29	1	8	1	CDCA5	11	64846584	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2429625	64846584	70159932	257	18182										
SLC22A20	440044	broad.mit.edu	37	chr11	64981715	64981715	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtgttttcccgtccaccatCgtgatggaggtcagaagggg	14	9	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:64981715C>G	uc010roc.1	+	1	369	c.366C>G	c.(364-366)ATC>ATG	p.I122M	SLC22A20_uc010rob.1_Missense_Mutation_p.I122M	NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	122	Extracellular (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						CGTCCACCATCGTGATGGAGG	0.657													0	0	0	0.009096	0	4	12										G	64981715	C	G	64981715	3	3	62	1	0	0	0	0	1	0	0	0	14451	874	31	1	374	1	SLC22A20	11	64981715	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	135131	64981715	70024801	258	18183										
SF3B2	10992	broad.mit.edu	37	chr11	65824372	65824372	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agatgggcaccccagtccctCggcccccacaagacatgggc	11	17	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65824372C>T	uc001ogy.1	+	6	653	c.613C>T	c.(613-615)CGG>TGG	p.R205W	SF3B2_uc001ogx.1_Missense_Mutation_p.R204W	NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	205					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						CCCAGTCCCTCGGCCCCCACA	0.587													0	0	0	0.012319	0	17	66										T	65824372	C	T	65824372	3	4	62	1	0	0	0	0	1	0	0	0	14151	875	31	1	635	1	SF3B2	11	65824372	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	842657	65824372	69182144	259	18184										
CLCF1	23529	broad.mit.edu	37	chr11	67134963	67134963	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caagctgcggagttggtgctCcaggtagcgggtgaggtcat	17	8	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:67134963C>G	uc001okq.2	-	2	347	c.151G>C	c.(151-153)GAG>CAG	p.E51Q	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Missense_Mutation_p.E41Q	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	51					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			AGTTGGTGCTCCAGGTAGCGG	0.602													0	0	0	0.00874	0	37	97										G	67134963	C	G	67134963	3	3	62	1	0	0	0	0	1	0	0	0	3461	864	30	1	534	1	CLCF1	11	67134963	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1310591	67134963	67871553	260	18185										
SHANK2	22941	broad.mit.edu	37	chr11	70332669	70332669	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcaatgtaaagaggtttgttGaggtcggccttgggggcctc	15	7	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:70332669G>A	uc001oqc.2	-	21	3807	c.3729C>T	c.(3727-3729)CTC>CTT	p.L1243L	SHANK2_uc010rqn.1_Silent_p.L655L|SHANK2_uc001opz.2_Silent_p.L648L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	864					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAGGTTTGTTGAGGTCGGCCT	0.632													0	0	0	0.008291	0	8	97										A	70332669	G	A	70332669	2	1	62	1	0	0	0	0	0	0	0	1	14265	1277	45	1		1	SHANK2	11	70332669	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3197706	70332669	64673847	261	18186										
ARAP1	116985	broad.mit.edu	37	chr11	72437906	72437906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcaggcacaggtggtgagcGgaagatgtggcgcttcatgg	19	7	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:72437906G>A	uc001osu.2	-	3	457	c.268C>T	c.(268-270)CGC>TGC	p.R90C	ARAP1_uc001osv.2_Missense_Mutation_p.R90C	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	90					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GGTGGTGAGCGGAAGATGTGG	0.726													0	0	0	0.009096	0	3	14										A	72437906	G	A	72437906	3	1	62	1	0	0	0	0	1	0	0	0	838	1116	39	2	4216	2	ARAP1	11	72437906	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2105237	72437906	62568610	262	18187										
C2CD3	26005	broad.mit.edu	37	chr11	73814626	73814626	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttgccacttaacttagtattGataccagtgaaatctttgtt	6	7	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:73814626G>C	uc001ouu.2	-	14	2357	c.2130C>G	c.(2128-2130)ATC>ATG	p.I710M		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	710						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ACTTAGTATTGATACCAGTGA	0.373													0	0	0	0.004656	0	26	47										C	73814626	G	C	73814626	3	2	62	1	0	0	0	0	1	0	0	0	2154	1280	45	1	3833	1	C2CD3	11	73814626	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1376720	73814626	61191890	263	18188										
SERPINH1	871	broad.mit.edu	37	chr11	75282943	75282943	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgttccacgccaccgcctttGagttggacacagatggcaac	10	13	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:75282943G>C	uc001owr.2	+	5	1301	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	SERPINH1_uc009yug.2_Missense_Mutation_p.E358Q|SERPINH1_uc001ows.2_Missense_Mutation_p.E358Q|SERPINH1_uc001owt.2_Missense_Mutation_p.E141Q	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	358					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					CACCGCCTTTGAGTTGGACAC	0.597													0	0	0	0.014323	0	17	27										C	75282943	G	C	75282943	3	2	62	1	0	0	0	0	1	0	0	0	14117	1291	45	1	1086	1	SERPINH1	11	75282943	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1468317	75282943	59723573	264	18189										
GDPD4	220032	broad.mit.edu	37	chr11	76980082	76980082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atagagacctaaaaggataaGaagaaagggtaatccaacag	10	5	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:76980082G>A	uc001oyf.2	-	8	762	c.511C>T	c.(511-513)CTT>TTT	p.L171F		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	171	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						AAAAGGATAAGAAGAAAGGGT	0.438													0	0	0	0.00308	0	7	38										A	76980082	G	A	76980082	3	1	62	1	0	0	0	0	1	0	0	0	6326	942	33	1	1087	1	GDPD4	11	76980082	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1697139	76980082	58026434	265	18190										
NARS2	79731	broad.mit.edu	37	chr11	78239958	78239958	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacattgaagaaattctcctCaggtaccttaagtttgcctg	7	9	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:78239958C>T	uc001ozi.2	-	6	995	c.619G>A	c.(619-621)GAG>AAG	p.E207K	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	207					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	AAATTCTCCTCAGGTACCTTA	0.353													0	0	0	0.006999	0	35	75										T	78239958	C	T	78239958	3	4	62	1	0	0	0	0	1	0	0	0	10171	835	29	1	850	1	NARS2	11	78239958	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1259876	78239958	56766558	266	18191										
EED	8726	broad.mit.edu	37	chr11	85961447	85961447	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggaaagggaaaatggaagtCaaagaaatgcaaatattctt	11	3	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:85961447C>G	uc001pbp.2	+	2	681	c.224C>G	c.(223-225)TCA>TGA	p.S75*	EED_uc010rtm.1_Nonsense_Mutation_p.S75*|EED_uc001pbq.2_Nonsense_Mutation_p.S75*|EED_uc001pbr.2_Nonsense_Mutation_p.S75*|EED_uc001pbs.2_Nonsense_Mutation_p.S75*	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	75					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				AAATGGAAGTCAAAGAAATGC	0.388													0	0	0	0.013726	0	31	72										G	85961447	C	G	85961447	4	3	62	1	0	0	0	0	0	1	0	0	4922	838	29	1	230	1	EED	11	85961447	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7721489	85961447	49045069	267	18192										
NAALAD2	10003	broad.mit.edu	37	chr11	89896561	89896561	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtggggttgctgttttgcaaGaaattgcccggagttttgga	15	5	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:89896561G>A	uc001pdf.3	+	10	1268	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K	NAALAD2_uc009yvx.2_Missense_Mutation_p.E354K|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pde.2_Missense_Mutation_p.E294K	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	387	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGTTTTGCAAGAAATTGCCCG	0.398													0	0	0	0.01441	0	52	101										A	89896561	G	A	89896561	3	1	62	1	0	0	0	0	1	0	0	0	10128	943	33	1	1197	1	NAALAD2	11	89896561	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3935114	89896561	45109955	268	18193										
PIWIL4	143689	broad.mit.edu	37	chr11	94316613	94316613	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttaagtacctctttttcccaGgtcacagagttgtcaagtga	8	9	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:94316613G>A	uc001pfa.2	+	5	725	c.514_splice	c.e5-1	p.V172_splice	PIWIL4_uc010rue.1_Splice_Site|PIWIL4_uc009ywk.1_Splice_Site	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTTTTTCCCAGGTCACAGAGT	0.418													0	0	0	0.01441	0	71	165										A	94316613	G	A	94316613	5	1	62	1	0	0	0	0	0	0	1	0	11960	1014	35	2	531	2	PIWIL4	11	94316613	Splice_Site	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4420052	94316613	40689903	269	18194										
CASP5	838	broad.mit.edu	37	chr11	104871143	104871143	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttccctctaggatgccatgaGacatgagtaccaagaacgtg	10	10	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:104871143G>A	uc010rva.1	-	6	829	c.797C>T	c.(796-798)TCT>TTT	p.S266F	CASP5_uc010ruz.1_Missense_Mutation_p.S279F|CASP5_uc010rvb.1_Missense_Mutation_p.S208F|CASP5_uc010rvc.1_Missense_Mutation_p.S124F|CASP5_uc009yxh.2_Missense_Mutation_p.S48F|CASP5_uc010rvd.1_Missense_Mutation_p.S48F	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	266					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GATGCCATGAGACATGAGTAC	0.463													0	0	0	0.005443	0	23	70										A	104871143	G	A	104871143	3	1	62	1	0	0	0	0	1	0	0	0	2674	942	33	1	523	1	CASP5	11	104871143	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10554530	104871143	30135373	270	18195										
SLC35F2	54733	broad.mit.edu	37	chr11	107673745	107673745	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	accttatagccaaacagaaaGagtccaacaaaaaggctgta	7	9	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:107673745G>C	uc001pjq.2	-	7	1342	c.921C>G	c.(919-921)CTC>CTG	p.L307L	SLC35F2_uc010rvu.1_Silent_p.L159L	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	307	Helical; (Potential).				transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAAACAGAAAGAGTCCAACAA	0.428													0	0	0	0.010504	0	18	42										C	107673745	G	C	107673745	2	2	62	1	0	0	0	0	0	0	0	1	14589	929	33	1		1	SLC35F2	11	107673745	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2802602	107673745	27332771	271	18196										
NPAT	4863	broad.mit.edu	37	chr11	108044182	108044182	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaccaagtgaaacaaatgaaGttattggtatatcaggctga	9	5	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:108044182G>C	uc001pjz.3	-	13	1631	c.1529C>G	c.(1528-1530)ACT>AGT	p.T510S	NPAT_uc001pka.2_Missense_Mutation_p.T305S	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	510					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		AACAAATGAAGTTATTGGTAT	0.363													0	0	0	0.01441	0	43	91										C	108044182	G	C	108044182	3	2	62	1	0	0	0	0	1	0	0	0	10566	1029	36	4	2778	4	NPAT	11	108044182	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	370437	108044182	26962334	272	18197										
SIK2	23235	broad.mit.edu	37	chr11	111594445	111594445	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atgcaatacagccctttcctCagccagtaccaagagatgca	7	13	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:111594445C>G	uc001plt.2	+	15	2491	c.2373C>G	c.(2371-2373)CTC>CTG	p.L791L		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	791					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						GCCCTTTCCTCAGCCAGTACC	0.632													0	0	0	0.01441	0	136	297										G	111594445	C	G	111594445	2	3	62	1	0	0	0	0	0	0	0	1	14318	813	29	1		1	SIK2	11	111594445	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3550263	111594445	23412071	273	18198										
DSCAML1	57453	broad.mit.edu	37	chr11	117302289	117302289	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcactgtagctgtcactctCagtgaccgtgacaccatgct	10	13	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:117302289C>G	uc001prh.1	-	31	5517	c.5515G>C	c.(5515-5517)GAG>CAG	p.E1839Q		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1779	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTGTCACTCTCAGTGACCGTG	0.632													0	0	0	0.014323	0	21	59										G	117302289	C	G	117302289	3	3	62	1	0	0	0	0	1	0	0	0	4769	835	29	1	838	1	DSCAML1	11	117302289	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5707844	117302289	17704227	274	18199										
MPZL2	10205	broad.mit.edu	37	chr11	118128003	118128003	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ataaacagagacctttttctCttggttgagcctttcctctt	6	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:118128003C>G	uc001psn.2	-	5	751	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	MPZL2_uc001pso.2_Missense_Mutation_p.E204Q	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	204	Cytoplasmic (Potential).				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ACCTTTTTCTCTTGGTTGAGC	0.388													0	0	0	0.001855	0	12	84										G	118128003	C	G	118128003	3	3	62	1	0	0	0	0	1	0	0	0	9750	922	32	1	41	1	MPZL2	11	118128003	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	825714	118128003	16878513	275	18200										
CBL	867	broad.mit.edu	37	chr11	119167741	119167741	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttggatacatcccagagttCacggtaggttcacaacaacc	8	11	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:119167741C>T	uc001pwe.2	+	13	2288	c.2150C>T	c.(2149-2151)TCA>TTA	p.S717L		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	717	Interaction with CD2AP.|Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TCCCAGAGTTCACGGTAGGTT	0.507									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				0	0	0	0.01441	0	40	71										T	119167741	C	T	119167741	3	4	62	1	0	0	0	0	1	0	0	0	2700	838	29	1	2200	1	CBL	11	119167741	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1039738	119167741	15838775	276	18201										
NFRKB	4798	broad.mit.edu	37	chr11	129762708	129762708	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atctccacacggaccaagttCcagaggatctgtcagcatat	8	12	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:129762708C>G	uc001qfi.2	-	3	238	c.37G>C	c.(37-39)GAA>CAA	p.E13Q	NFRKB_uc001qfg.2_Missense_Mutation_p.E26Q|NFRKB_uc001qfh.2_Missense_Mutation_p.E36Q|NFRKB_uc010sbw.1_Missense_Mutation_p.E13Q	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	13					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGACCAAGTTCCAGAGGATCT	0.517													0	0	0	0.012213	0	29	136										G	129762708	C	G	129762708	3	3	62	1	0	0	0	0	1	0	0	0	10384	864	30	1	3998	1	NFRKB	11	129762708	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10594967	129762708	5243808	277	18202										
B4GALNT3	283358	broad.mit.edu	37	chr12	660168	660168	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctatctggtggatgggcttCctctgcagcgctaccaggga	14	11	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:660168C>T	uc001qii.1	+	11	1078	c.1078C>T	c.(1078-1080)CCT>TCT	p.P360S	B4GALNT3_uc001qij.1_Missense_Mutation_p.P262S|B4GALNT3_uc001qik.1_5'Flank	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	360	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGATGGGCTTCCTCTGCAGCG	0.607													0	0	0	0.005524	0	31	69										T	660168	C	T	660168	3	4	62	1	0	0	0	0	1	0	0	0	1268	855	30	1	1120	1	B4GALNT3	12	660168	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		660168	133191727	278	18203										
DCP1B	196513	broad.mit.edu	37	chr12	2061674	2061674	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agagctctgagcgagcacagGaaacttagcggccaaggctg	14	10	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:2061674G>A	uc001qjx.1	-	7	1512	c.1432C>T	c.(1432-1434)CCT>TCT	p.P478S	DCP1B_uc010sdy.1_Missense_Mutation_p.P376S	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	478					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			GCGAGCACAGGAAACTTAGCG	0.512													0	0	0	0.00499	0	17	35										A	2061674	G	A	2061674	3	1	62	1	0	0	0	0	1	0	0	0	4299	1174	41	1	433	1	DCP1B	12	2061674	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1401506	2061674	131790221	279	18204										
LRP6	4040	broad.mit.edu	37	chr12	12318175	12318175	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caaagtaaatccaaatatgtGaggaattttgtcttccacta	6	7	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:12318175G>T	uc001rah.3	-	8	1742	c.1600C>A	c.(1600-1602)CAC>AAC	p.H534N	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.H534N	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	534	Beta-propeller 2.|Extracellular (Potential).|LDL-receptor class B 9.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CCAAATATGTGAGGAATTTTG	0.398													1	0	4.97629e-18	0.01441	5.61156e-18	58	126										T	12318175	G	T	12318175	3	4	62	1	0	0	0	0	1	0	0	0	8962	1290	45	3	3305	3	LRP6	12	12318175	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10256501	12318175	121533720	280	18205										
PIK3C2G	5288	broad.mit.edu	37	chr12	18650568	18650568	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacaggctggagatgatcttCgtcaggatatgcttgttctg	12	7	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:18650568C>T	uc001rdt.2	+	21	2895	c.2779C>T	c.(2779-2781)CGT>TGT	p.R927C	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R968C|PIK3C2G_uc010sic.1_Missense_Mutation_p.R746C	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	927	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AGATGATCTTCGTCAGGATAT	0.363													0	0	0	0.013537	0	8	41										T	18650568	C	T	18650568	3	4	62	1	0	0	0	0	1	0	0	0	11911	884	31	1	2857	1	PIK3C2G	12	18650568	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6332393	18650568	115201327	281	18206										
SLCO1B1	10599	broad.mit.edu	37	chr12	21392046	21392046	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaaatggaagtgtcatggatGaagcaaacttagaatcctta	9	5	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:21392046G>A	uc001req.3	+	15	2103	c.1999G>A	c.(1999-2001)GAA>AAA	p.E667K		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	667	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGTCATGGATGAAGCAAACTT	0.318													0	0	0	0.00308	0	8	28										A	21392046	G	A	21392046	3	1	62	1	0	0	0	0	1	0	0	0	14723	1291	45	1	2053	1	SLCO1B1	12	21392046	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2741478	21392046	112459849	282	18207										
ABCC9	10060	broad.mit.edu	37	chr12	21958120	21958120	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atgatggtctacttgttggtCatcaccaaagtggaaaagag	11	6	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:21958120C>T	uc001rfi.1	-	38	4658	c.4638G>A	c.(4636-4638)ATG>ATA	p.M1546I	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.M1510I|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1546	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.R1546H(1)		ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTGTTGGTCATCACCAAAG	0.438													0	0	0	0.010504	0	16	62										T	21958120	C	T	21958120	3	4	62	1	0	0	0	0	1	0	0	0	59	826	29	1	157	1	ABCC9	12	21958120	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	566074	21958120	111893775	283	18208										
IRAK4	51135	broad.mit.edu	37	chr12	44176171	44176171	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgactttggccttgcacggGcttctgagaagtttgcccag	12	11	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:44176171G>C	uc001rnu.3	+	10	1133	c.1003G>C	c.(1003-1005)GCT>CCT	p.A335P	IRAK4_uc001rnt.3_Missense_Mutation_p.A335P|IRAK4_uc001rnx.3_Missense_Mutation_p.A211P|IRAK4_uc001rny.3_Missense_Mutation_p.A211P|IRAK4_uc010sky.1_Missense_Mutation_p.A211P|IRAK4_uc001rnv.3_Missense_Mutation_p.A211P|IRAK4_uc001rnw.3_Missense_Mutation_p.A211P	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	335	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		CCTTGCACGGGCTTCTGAGAA	0.388													0	0	0	0.008871	0	16	41										C	44176171	G	C	44176171	3	2	62	1	0	0	0	0	1	0	0	0	7825	1203	42	4	1033	4	IRAK4	12	44176171	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	22218051	44176171	89675724	284	18209										
COL2A1	1280	broad.mit.edu	37	chr12	48375126	48375126	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcagaggggcagacactcacCggagcgccacgagcaccagc	13	15	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:48375126C>T	uc001rqu.2	-	37	2644	c.2463G>A	c.(2461-2463)CCG>CCA	p.P821P	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Silent_p.P752P	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	821	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGACACTCACCGGAGCGCCAC	0.662													0	0	0	0.010729	0	8	16										T	48375126	C	T	48375126	2	4	62	1	0	0	0	0	0	0	0	1	3687	666	23	2		2	COL2A1	12	48375126	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4198955	48375126	85476769	285	18210										
MLL2	8085	broad.mit.edu	37	chr12	49448457	49448457	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccaatcaaatggcaactcaAagcgccgtagctcccgctgc	9	15	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:49448457A>G	uc001rta.3	-	3	254	c.254T>C	c.(253-255)TTT>TCT	p.F85S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	85					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGCAACTCAAAGCGCCGTAG	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004672	0	3	10										G	49448457	A	G	49448457	3	3	62	1	0	0	0	0	1	0	0	0	9621	14	1	5	16567	5	MLL2	12	49448457	Missense_Mutation	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	1073331	49448457	84403438	286	18211										
KRT80	144501	broad.mit.edu	37	chr12	52574306	52574306	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atctcactcacctgctcataGatggttttcatcaactccac	4	14	5	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:52574306G>T	uc001rzx.2	-	4	755	c.657C>A	c.(655-657)ATC>ATA	p.I219I	KRT80_uc001rzw.2_Silent_p.I254I|KRT80_uc001rzy.2_Silent_p.I219I	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	219	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		CCTGCTCATAGATGGTTTTCA	0.552													1	0	4.67007e-22	0.00874	5.38073e-22	36	158										T	52574306	G	T	52574306	2	4	62	1	0	0	0	0	0	0	0	1	8494	932	33	3		3	KRT80	12	52574306	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3125849	52574306	81277589	287	18212										
KRT76	51350	broad.mit.edu	37	chr12	53165706	53165706	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agcctctggatcatcctgttGagctccatgatctcactctt	7	13	4	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:53165706G>C	uc001sax.2	-	6	1266	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	404	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						TCATCCTGTTGAGCTCCATGA	0.547													0	0	0	0.01441	0	44	91										C	53165706	G	C	53165706	2	2	62	1	0	0	0	0	0	0	0	1	8489	1277	45	1		1	KRT76	12	53165706	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	591400	53165706	80686189	288	18213										
PTPRB	5787	broad.mit.edu	37	chr12	70956762	70956762	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacttgagctctctcctggaGattcccatctgggttgtaca	9	11	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:70956762G>C	uc001swb.3	-	14	3406	c.3376C>G	c.(3376-3378)CTC>GTC	p.L1126V	PTPRB_uc010sto.1_Missense_Mutation_p.L1036V|PTPRB_uc010stp.1_Missense_Mutation_p.L1036V|PTPRB_uc001swc.3_Missense_Mutation_p.L1344V|PTPRB_uc001swa.3_Missense_Mutation_p.L1256V|PTPRB_uc001swd.3_Missense_Mutation_p.L1343V|PTPRB_uc009zrr.1_Missense_Mutation_p.L1223V	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1126	Fibronectin type-III 13.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCTCCTGGAGATTCCCATCT	0.512													0	0	0	0.004482	0	8	60										C	70956762	G	C	70956762	3	2	62	1	0	0	0	0	1	0	0	0	12796	942	33	1	2693	1	PTPRB	12	70956762	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	17791056	70956762	62895133	289	18214										
TBC1D15	64786	broad.mit.edu	37	chr12	72312286	72312286	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aggtggcttttaatcagattCaaaagggaatttagttttct	9	4	3	1	rs141790587	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:72312286C>T	uc001swu.2	+	15	1683	c.1674C>T	c.(1672-1674)TTC>TTT	p.F558F	TBC1D15_uc010stt.1_Silent_p.F527F|TBC1D15_uc001swv.2_Silent_p.F541F|TBC1D15_uc001sww.2_Silent_p.F290F	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	536	Rab-GAP TBC.						protein binding|Rab GTPase activator activity				0						TAATCAGATTCAAAAGGGAAT	0.294													0	0	0	0.003271	0	27	92										T	72312286	C	T	72312286	2	4	62	1	0	0	0	0	0	0	0	1	15601	825	29	1		1	TBC1D15	12	72312286	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1355524	72312286	61539609	290	18215										
NAV3	89795	broad.mit.edu	37	chr12	78400995	78400995	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaattcaggactaccaagggGagcccttcccagtccttatc	8	13	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:78400995G>A	uc001syp.2	+	8	1850	c.1677G>A	c.(1675-1677)GGG>GGA	p.G559G	NAV3_uc001syo.2_Silent_p.G559G	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	559						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTACCAAGGGGAGCCCTTCCC	0.483										HNSCC(70;0.22)			0	0	0	0.014323	0	19	46										A	78400995	G	A	78400995	2	1	62	1	0	0	0	0	0	0	0	1	10185	1161	41	1		1	NAV3	12	78400995	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	6088709	78400995	55450900	291	18216										
LRRIQ1	84125	broad.mit.edu	37	chr12	85450069	85450069	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagaagaattggtcaagcaaGaaagaaaatatgaaaataca	8	4	1	5			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:85450069G>A	uc001tac.2	+	8	1609	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	LRRIQ1_uc001tab.1_Missense_Mutation_p.E500K|LRRIQ1_uc001taa.1_Missense_Mutation_p.E475K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	500										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GGTCAAGCAAGAAAGAAAATA	0.303													0	0	0	0.001855	0	10	37										A	85450069	G	A	85450069	3	1	62	1	0	0	0	0	1	0	0	0	9029	943	33	1	1524	1	LRRIQ1	12	85450069	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	7049074	85450069	48401826	292	18217										
UTP20	27340	broad.mit.edu	37	chr12	101682793	101682793	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atataagaaattttgctgctGaaagttttacttttttgatg	7	3	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:101682793G>C	uc001tia.1	+	6	727	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	UTP20_uc009ztz.1_Missense_Mutation_p.E191Q	NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	191	HEAT 1.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TTTTGCTGCTGAAAGTTTTAC	0.254													0	0	0	0.006214	0	8	29										C	101682793	G	C	101682793	3	2	62	1	0	0	0	0	1	0	0	0	17096	1291	45	1	593	1	UTP20	12	101682793	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	16232724	101682793	32169102	293	18218										
UTP20	27340	broad.mit.edu	37	chr12	101767377	101767377	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttttaggggctgctccatgaGaactgcggaatgttctttat	11	7	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:101767377G>C	uc001tia.1	+	54	7119	c.6963G>C	c.(6961-6963)GAG>GAC	p.E2321D		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2321					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TGCTCCATGAGAACTGCGGAA	0.478													0	0	0	0.007413	0	15	25										C	101767377	G	C	101767377	3	2	62	1	0	0	0	0	1	0	0	0	17096	933	33	1	7177	1	UTP20	12	101767377	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	84584	101767377	32084518	294	18219										
NT5DC3	51559	broad.mit.edu	37	chr12	104187715	104187715	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgatactgctgagcacatacCaatgtctgcttcaattgctc	7	11	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:104187715C>G	uc010swe.1	-	7	855	c.814G>C	c.(814-816)GAA>CAA	p.E272Q		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	272							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						GAGCACATACCAATGTCTGCT	0.413													0	0	0	0.008361	0	21	80										G	104187715	C	G	104187715	3	3	62	1	0	0	0	0	1	0	0	0	10692	608	21	4	864	4	NT5DC3	12	104187715	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2420338	104187715	29664180	295	18220										
BRAP	8315	broad.mit.edu	37	chr12	112123571	112123571	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtgttccgcgagctccaatCggataacaaccagtgacaca	9	12	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:112123571C>G	uc001tsn.3	-	1	220	c.26G>C	c.(25-27)CGA>CCA	p.R9P	BRAP_uc009zvv.2_5'Flank|ACAD10_uc009zvw.2_5'Flank|ACAD10_uc001tso.3_5'Flank|ACAD10_uc001tsp.2_5'Flank|ACAD10_uc009zvx.2_5'Flank|ACAD10_uc001tsq.2_5'Flank	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	9					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						GAGCTCCAATCGGATAACAAC	0.612													0	0	0	0.008291	0	9	12										G	112123571	C	G	112123571	3	3	62	1	0	0	0	0	1	0	0	0	1497	884	31	1	1800	1	BRAP	12	112123571	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7935856	112123571	21728324	296	18221										
RNF10	9921	broad.mit.edu	37	chr12	121001720	121001720	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agatctcagcaactgtggtgGagattgctggctactccatg	12	9	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:121001720G>C	uc001typ.3	+	10	2122	c.1639G>C	c.(1639-1641)GAG>CAG	p.E547Q	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.E458Q	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	547					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AACTGTGGTGGAGATTGCTGG	0.552													0	0	0	0.004656	0	19	153										C	121001720	G	C	121001720	3	2	62	1	0	0	0	0	1	0	0	0	13422	1175	41	1	1677	1	RNF10	12	121001720	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	8878149	121001720	12850175	297	18222										
KNTC1	9735	broad.mit.edu	37	chr12	123095437	123095437	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgtttgtatttgcaacatCaactacaaccgtaagctcta	6	10	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:123095437C>T	uc001ucv.2	+	53	5775	c.5612C>T	c.(5611-5613)TCA>TTA	p.S1871L	KNTC1_uc010taf.1_Missense_Mutation_p.S796L	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1871					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTTGCAACATCAACTACAACC	0.333													0	0	0	0.003163	0	12	47										T	123095437	C	T	123095437	3	4	62	1	0	0	0	0	1	0	0	0	8428	838	29	1	5818	1	KNTC1	12	123095437	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2093717	123095437	10756458	298	18223										
ULK1	8408	broad.mit.edu	37	chr12	132404537	132404537	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttgcagtggtgcgcaggctGaatgagctgtacaaggccag	15	8	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:132404537G>C	uc001uje.2	+	26	3085	c.2817G>C	c.(2815-2817)CTG>CTC	p.L939L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	939					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGCGCAGGCTGAATGAGCTGT	0.647													0	0	0	0.010729	0	9	48										C	132404537	G	C	132404537	2	2	62	1	0	0	0	0	0	0	0	1	16972	1277	45	1		1	ULK1	12	132404537	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	9309100	132404537	1447358	299	18224										
MPHOSPH8	54737	broad.mit.edu	37	chr13	20242605	20242605	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttttccaatcgcatgtcatCgactctgtgagggtccagat	9	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:20242605C>G	uc001umh.2	+	11	2272	c.2263C>G	c.(2263-2265)CGA>GGA	p.R755G	MPHOSPH8_uc001umg.2_Missense_Mutation_p.R755G	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	755					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		CGCATGTCATCGACTCTGTGA	0.413													0	0	0	0.006214	0	10	32										G	20242605	C	G	20242605	3	3	62	1	0	0	0	0	1	0	0	0	9727	876	31	1	2305	1	MPHOSPH8	13	20242605	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		20242605	94927273	300	18225										
XPO4	64328	broad.mit.edu	37	chr13	21442798	21442798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaatgataagaatatgtgctCtgcatgctggcgttgttcat	10	6	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:21442798C>G	uc001unq.3	-	2	148	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	XPO4_uc010tcr.1_Intron	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	38					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AATATGTGCTCTGCATGCTGG	0.323													0	0	0	0.01441	0	54	121										G	21442798	C	G	21442798	3	3	62	1	0	0	0	0	1	0	0	0	17443	922	32	1	3431	1	XPO4	13	21442798	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1200193	21442798	93727080	301	18226										
ATP12A	479	broad.mit.edu	37	chr13	25280593	25280593	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgatcattgtggagggctgtCagaggcaggtgggtggacag	19	5	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:25280593C>A	uc001upp.2	+	15	2348	c.2161C>A	c.(2161-2163)CAG>AAG	p.Q721K	ATP12A_uc010aaa.2_Missense_Mutation_p.Q727K	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	721	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGAGGGCTGTCAGAGGCAGGT	0.567													1	0	7.87624e-14	0.00278	8.5829e-14	18	29										A	25280593	C	A	25280593	3	1	62	1	0	0	0	0	1	0	0	0	1122	827	29	3	2237	3	ATP12A	13	25280593	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3837795	25280593	89889285	302	18227										
USPL1	10208	broad.mit.edu	37	chr13	31205593	31205593	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atacacttctatataccagtCaattgagtggtgttaaaggt	8	6	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:31205593C>T	uc001utc.2	+	4	1282	c.850C>T	c.(850-852)CAA>TAA	p.Q284*	USPL1_uc001utb.2_Nonsense_Mutation_p.Q103*|USPL1_uc001utd.2_Intron|USPL1_uc001ute.1_5'Flank	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	284					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		ATATACCAGTCAATTGAGTGG	0.249													0	0	0	0.00333	0	20	62										T	31205593	C	T	31205593	4	4	62	1	0	0	0	0	0	1	0	0	17089	827	29	1	860	1	USPL1	13	31205593	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5925000	31205593	83964285	303	18228										
FRY	10129	broad.mit.edu	37	chr13	32808828	32808828	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggccctcaagcaacctctgtCagcacatgccttatctgacc	7	16	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:32808828C>A	uc001utx.2	+	42	6141	c.5645C>A	c.(5644-5646)TCA>TAA	p.S1882*	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CAACCTCTGTCAGCACATGCC	0.512													1	0	4.35082e-09	0.010504	4.63716e-09	17	41										A	32808828	C	A	32808828	4	1	62	1	0	0	0	0	0	1	0	0	6063	838	29	3	5811	3	FRY	13	32808828	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1603235	32808828	82361050	304	18229										
STOML3	161003	broad.mit.edu	37	chr13	39540963	39540963	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgactaccgcaagaggacctCaggctttatttggaagcttc	10	10	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:39540963C>T	uc001uwx.2	-	7	1013	c.875G>A	c.(874-876)TGA>TAA	p.*292*	STOML3_uc010tez.1_Silent_p.*283*	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	292						integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		AAGAGGACCTCAGGCTTTATT	0.443													0	0	0	0.005524	0	29	59										T	39540963	C	T	39540963	2	4	62	1	0	0	0	0	0	0	0	1	15314	837	29	1		1	STOML3	13	39540963	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6732135	39540963	75628915	305	18230										
PCDH8	5100	broad.mit.edu	37	chr13	53419572	53419572	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtcctcaccactctgcatgtGgttgatgagatcctttttca	8	11	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:53419572G>C	uc001vhi.2	-	2	3030	c.2827C>G	c.(2827-2829)CAC>GAC	p.H943D	PCDH8_uc001vhj.2_Missense_Mutation_p.H846D	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	943	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCTGCATGTGGTTGATGAGA	0.532													0	0	0	0.013726	0	29	39										C	53419572	G	C	53419572	3	2	62	1	0	0	0	0	1	0	0	0	11517	1348	47	4	393	4	PCDH8	13	53419572	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	13878609	53419572	61750306	306	18231										
DACH1	1602	broad.mit.edu	37	chr13	72053449	72053449	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atggcaactttcaacagcccCtgtacaaagaagatattcgg	8	10	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:72053449C>T	uc010thn.1	-	9	2146	c.1723_splice	c.e9-1	p.G575_splice	DACH1_uc010tho.1_Splice_Site_p.G427_splice|DACH1_uc010thp.1_Splice_Site_p.G373_splice	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCAACAGCCCCTGTACAAAGA	0.358													0	0	0	0.003755	0	26	109										T	72053449	C	T	72053449	5	4	62	1	0	0	0	0	0	0	1	0	4220	695	24	2	414	2	DACH1	13	72053449	Splice_Site	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	18633877	72053449	43116429	307	18232										
RNF219	79596	broad.mit.edu	37	chr13	79190193	79190193	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cactgccttgagatgactttGataacccatccaaatccagt	6	12	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:79190193G>C	uc001vkw.1	-	6	1762	c.1703C>G	c.(1702-1704)TCA>TGA	p.S568*	uc001vku.1_RNA|RNF219_uc010afb.1_Nonsense_Mutation_p.S378*|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	568	Ser-rich.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		AGATGACTTTGATAACCCATC	0.383													0	0	0	0.01441	0	63	133										C	79190193	G	C	79190193	4	2	62	1	0	0	0	0	0	1	0	0	13482	1294	45	1	481	1	RNF219	13	79190193	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	7136744	79190193	35979685	308	18233										
CLYBL	171425	broad.mit.edu	37	chr13	100523272	100523272	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgaaaaaattaagtgggctGaagaactgattgctgccttt	10	6	0	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:100523272G>A	uc001vok.2	+	7	897	c.883G>A	c.(883-885)GAA>AAA	p.E295K	CLYBL_uc010tiy.1_Missense_Mutation_p.E261K	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	295					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TAAGTGGGCTGAAGAACTGAT	0.393													0	0	0	0.00333	0	22	69										A	100523272	G	A	100523272	3	1	62	1	0	0	0	0	1	0	0	0	3573	1291	45	1	909	1	CLYBL	13	100523272	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	21333079	100523272	14646606	309	18234										
SALL2	6297	broad.mit.edu	37	chr14	21991095	21991095	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atgctcctccagagctgcctGggagggaaaggcctggccac	14	13	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:21991095G>A	uc001wbe.2	-	2	3049	c.2767C>T	c.(2767-2769)CAG>TAG	p.Q923*	SALL2_uc010tly.1_Nonsense_Mutation_p.Q921*|SALL2_uc010tlz.1_Nonsense_Mutation_p.Q786*|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Nonsense_Mutation_p.Q788*|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	923	C2H2-type 6.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGAGCTGCCTGGGAGGGAAAG	0.597													0	0	0	0.00632	0	27	68										A	21991095	G	A	21991095	4	1	62	1	0	0	0	0	0	1	0	0	13811	1357	47	2	260	2	SALL2	14	21991095	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		21991095	85358445	310	18235										
LRP10	26020	broad.mit.edu	37	chr14	23342569	23342569	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaagtgcagggcaccttacaGaggcccctggtccgggacag	15	12	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23342569G>C	uc001whd.2	+	3	682	c.129G>C	c.(127-129)CAG>CAC	p.Q43H	LRP10_uc001whe.2_5'Flank	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	43	CUB 1.|Extracellular (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GCACCTTACAGAGGCCCCTGG	0.602													0	0	0	0.005443	0	26	53										C	23342569	G	C	23342569	3	2	62	1	0	0	0	0	1	0	0	0	8952	933	33	1	139	1	LRP10	14	23342569	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1351474	23342569	84006971	311	18236										
ACIN1	22985	broad.mit.edu	37	chr14	23530572	23530572	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcggcggtcacgggaccttGatcgggaacggggcccttct	17	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23530572G>C	uc001wit.3	-	17	3861	c.3533C>G	c.(3532-3534)TCA>TGA	p.S1178*	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Nonsense_Mutation_p.S420*|ACIN1_uc001wiq.3_Nonsense_Mutation_p.S420*|ACIN1_uc001wir.3_Nonsense_Mutation_p.S451*|ACIN1_uc001wis.3_Nonsense_Mutation_p.S859*|ACIN1_uc010akg.2_Nonsense_Mutation_p.S1165*	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1178	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ACGGGACCTTGATCGGGAACG	0.567													0	0	0	0.00623	0	33	105										C	23530572	G	C	23530572	4	2	62	1	0	0	0	0	0	1	0	0	142	1294	45	1	504	1	ACIN1	14	23530572	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	188003	23530572	83818968	312	18237										
MYH6	4624	broad.mit.edu	37	chr14	23858626	23858626	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccctcctcctccagctgcctTttgaggtcctccatttgctg	7	17	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23858626T>G	uc001wjv.2	-	28	4021	c.3954A>C	c.(3952-3954)AAA>AAC	p.K1318N	uc010tnn.1_5'Flank|MIR208A_hsa-mir-208a|MI0000251_5'Flank	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1318	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCAGCTGCCTTTTGAGGTCCT	0.607													0	0	0	0.006122	0	16	124										G	23858626	T	G	23858626	3	3	62	1	0	0	0	0	1	0	0	0	10038	1838	64	5	1913	5	MYH6	14	23858626	Missense_Mutation	SNP	T	TCGA-DK-A3IT-01A-31D-A20D-08	328054	23858626	83490914	313	18238										
MYH7	4625	broad.mit.edu	37	chr14	23891402	23891402	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acagtactttttcagccgctCatccagctgctgcttgtcat	7	13	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23891402C>G	uc001wjx.2	-	25	3338	c.3232G>C	c.(3232-3234)GAG>CAG	p.E1078Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1078	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCAGCCGCTCATCCAGCTGC	0.592													0	0	0	0.003271	0	27	89										G	23891402	C	G	23891402	3	3	62	1	0	0	0	0	1	0	0	0	10039	835	29	1	2639	1	MYH7	14	23891402	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	32776	23891402	83458138	314	18239										
RABGGTA	5875	broad.mit.edu	37	chr14	24738898	24738898	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccgccgatagtcccagcagtGaactggaggggagaggtgac	16	10	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:24738898G>A	uc001wof.2	-	5	852	c.430C>T	c.(430-432)CAC>TAC	p.H144Y	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.H144Y|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	144	PFTA 3.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		TCCCAGCAGTGAACTGGAGGG	0.587													0	0	0	0.013537	0	11	13										A	24738898	G	A	24738898	3	1	62	1	0	0	0	0	1	0	0	0	12967	1290	45	1	1321	1	RABGGTA	14	24738898	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	847496	24738898	82610642	315	18240										
CDKL1	8814	broad.mit.edu	37	chr14	50825768	50825768	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tctttggtatctgtccaactCatggagaactgtgtggtcac	10	9	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:50825768C>T	uc010anu.1	-	14	2083	c.2083G>A	c.(2083-2085)GAG>AAG	p.E695K	CDKL1_uc001wxz.2_Missense_Mutation_p.E91K	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	90	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					CTGTCCAACTCATGGAGAACT	0.453													0	0	0	0.01441	0	50	145										T	50825768	C	T	50825768	3	4	62	1	0	0	0	0	1	0	0	0	3153	835	29	1	837	1	CDKL1	14	50825768	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	26086870	50825768	56523772	316	18241										
TXNDC16	57544	broad.mit.edu	37	chr14	52905928	52905928	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacagaaaacttactgatatGattttctagtcctgcttcta	5	8	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:52905928G>C	uc001wzs.2	-	20	2637	c.2188C>G	c.(2188-2190)CAT>GAT	p.H730D	TXNDC16_uc010tqu.1_Missense_Mutation_p.H725D|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	730					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					TTACTGATATGATTTTCTAGT	0.333													0	0	0	0.008291	0	9	41										C	52905928	G	C	52905928	3	2	62	1	0	0	0	0	1	0	0	0	16792	1290	45	1	297	1	TXNDC16	14	52905928	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2080160	52905928	54443612	317	18242										
GMFB	2764	broad.mit.edu	37	chr14	54950455	54950455	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagcttttccactaaatcttCggcaacatcacaaacaacca	3	14	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:54950455C>A	uc010tqz.1	-	2	133	c.34G>T	c.(34-36)GAA>TAA	p.E12*	GMFB_uc001xaw.1_RNA	NM_004124	NP_004115	P60983	GMFB_HUMAN	glia maturation factor, beta	12	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity				0						ACTAAATCTTCGGCAACATCA	0.338													1	0	3.32936e-07	0.006122	3.50364e-07	11	29										A	54950455	C	A	54950455	4	1	62	1	0	0	0	0	0	1	0	0	6489	893	31	3	418	3	GMFB	14	54950455	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2044527	54950455	52399085	318	18243										
ARID4A	5926	broad.mit.edu	37	chr14	58831818	58831818	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtagtccaacataacttttCagtagcttcaccacttactc	4	12	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:58831818C>G	uc001xdp.2	+	20	3265	c.3011C>G	c.(3010-3012)TCA>TGA	p.S1004*	ARID4A_uc001xdo.2_Nonsense_Mutation_p.S1004*|ARID4A_uc001xdq.2_Nonsense_Mutation_p.S1004*|ARID4A_uc010apg.1_Nonsense_Mutation_p.S682*	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	1004					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CATAACTTTTCAGTAGCTTCA	0.403													0	0	0	0.010504	0	19	170										G	58831818	C	G	58831818	4	3	62	1	0	0	0	0	0	1	0	0	919	838	29	1	3085	1	ARID4A	14	58831818	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3881363	58831818	48517722	319	18244										
KIAA0586	9786	broad.mit.edu	37	chr14	58895165	58895165	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttggaacggggactagtttGaatggaacatcacgtggtat	14	5	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:58895165G>C	uc001xdv.3	+	1	456	c.183G>C	c.(181-183)TTG>TTC	p.L61F	KIAA0586_uc010trr.1_Missense_Mutation_p.L61F|KIAA0586_uc001xdt.3_Intron|KIAA0586_uc001xdu.3_Missense_Mutation_p.L46F|KIAA0586_uc010trs.1_Intron|TIMM9_uc010aph.2_5'Flank|TIMM9_uc001xds.2_5'Flank|TIMM9_uc010api.2_5'Flank	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	61										ovary(1)	1						GGACTAGTTTGAATGGAACAT	0.383													0	0	0	0.004656	0	20	55										C	58895165	G	C	58895165	3	2	62	1	0	0	0	0	1	0	0	0	8186	1281	45	1	185	1	KIAA0586	14	58895165	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	63347	58895165	48454375	320	18245										
PPP2R5E	5529	broad.mit.edu	37	chr14	63851225	63851225	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgatgggaaggatgacgttaGagttttcttctatcaaactc	10	6	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:63851225G>C	uc001xgd.1	-	12	1729	c.1139C>G	c.(1138-1140)TCT>TGT	p.S380C	PPP2R5E_uc010tsf.1_Missense_Mutation_p.S304C|PPP2R5E_uc010tsg.1_Missense_Mutation_p.S304C|PPP2R5E_uc001xge.2_Missense_Mutation_p.S380C|PPP2R5E_uc010tsh.1_Missense_Mutation_p.S380C|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	380					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GATGACGTTAGAGTTTTCTTC	0.363													0	0	0	0.01441	0	47	123										C	63851225	G	C	63851225	3	2	62	1	0	0	0	0	1	0	0	0	12396	942	33	1	276	1	PPP2R5E	14	63851225	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4956060	63851225	43498315	321	18246										
SYNE2	23224	broad.mit.edu	37	chr14	64518876	64518876	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggccaagaatttgttgggtGaacttaatccctccattccc	9	11	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:64518876G>A	uc001xgm.2	+	48	8475	c.8245G>A	c.(8245-8247)GAA>AAA	p.E2749K	SYNE2_uc001xgl.2_Missense_Mutation_p.E2749K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2749	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTGTTGGGTGAACTTAATCC	0.413													0	0	0	0.01441	0	61	199										A	64518876	G	A	64518876	3	1	62	1	0	0	0	0	1	0	0	0	15443	1291	45	1	8431	1	SYNE2	14	64518876	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	667651	64518876	42830664	322	18247										
TTC8	123016	broad.mit.edu	37	chr14	89336504	89336504	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgcattggaagcaaccacttCtattctgatcagccagaaat	7	10	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:89336504C>G	uc010ath.2	+	11	1193	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	TTC8_uc001xxl.2_Missense_Mutation_p.F98L|TTC8_uc010ati.2_Missense_Mutation_p.F139L|TTC8_uc001xxm.2_Missense_Mutation_p.F297L|TTC8_uc010atj.2_Missense_Mutation_p.F72L|TTC8_uc001xxi.2_Missense_Mutation_p.F337L|TTC8_uc001xxj.2_Missense_Mutation_p.F327L|TTC8_uc001xxk.2_Missense_Mutation_p.F297L	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	363	TPR 5.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						GCAACCACTTCTATTCTGATC	0.363									Bardet-Biedl_syndrome				0	0	0	0.01441	0	94	131										G	89336504	C	G	89336504	3	3	62	1	0	0	0	0	1	0	0	0	16711	912	32	1	1053	1	TTC8	14	89336504	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	24817628	89336504	18013036	323	18248										
TDP1	55775	broad.mit.edu	37	chr14	90429788	90429788	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caggctgagaaagtggtgatCaaaaaggagaaagacatctc	12	6	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:90429788C>G	uc001xxy.2	+	3	629	c.330C>G	c.(328-330)ATC>ATG	p.I110M	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.I110M|TDP1_uc010atn.2_Missense_Mutation_p.I110M|TDP1_uc001xya.2_Translation_Start_Site|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.I110M|TDP1_uc001xyc.1_Missense_Mutation_p.I110M	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	110					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		AAGTGGTGATCAAAAAGGAGA	0.542								Repair_of_DNA-protein_crosslinks					0	0	0	0.004656	0	24	53										G	90429788	C	G	90429788	3	3	62	1	0	0	0	0	1	0	0	0	15725	816	29	1	332	1	TDP1	14	90429788	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1093284	90429788	16919752	324	18249										
GPR68	8111	broad.mit.edu	37	chr14	91701248	91701248	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agctcgttccgggccttgatCtgcaggtagccgaagtagag	14	10	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:91701248C>G	uc001xzg.2	-	2	488	c.147G>C	c.(145-147)CAG>CAC	p.Q49H	GPR68_uc001xzh.2_Missense_Mutation_p.Q59H	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	49	Cytoplasmic (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity	p.N49S(1)		kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		GGGCCTTGATCTGCAGGTAGC	0.622													0	0	0	0.010504	0	15	32										G	91701248	C	G	91701248	3	3	62	1	0	0	0	0	1	0	0	0	6707	912	32	1	954	1	GPR68	14	91701248	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1271460	91701248	15648292	325	18250										
TRIP11	9321	broad.mit.edu	37	chr14	92471718	92471718	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttccctgagtcgttccaattCttcttgcagatgattatttt	6	9	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:92471718C>G	uc001xzy.2	-	11	3390	c.2602G>C	c.(2602-2604)GAA>CAA	p.E868Q	TRIP11_uc010auf.1_Missense_Mutation_p.E604Q	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	868	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CGTTCCAATTCTTCTTGCAGA	0.418			T	PDGFRB	AML								0	0	0	0.004656	0	24	68										G	92471718	C	G	92471718	3	3	62	1	0	0	0	0	1	0	0	0	16552	922	32	1	3381	1	TRIP11	14	92471718	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	770470	92471718	14877822	326	18251										
HSP90AA1	3320	broad.mit.edu	37	chr14	102551299	102551299	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtcttccttttcttcagcctCatcatcgcttacttctttat	3	13	6	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:102551299C>A	uc001yku.3	-	5	890	c.700G>T	c.(700-702)GAG>TAG	p.E234*	HSP90AA1_uc001ykv.3_Nonsense_Mutation_p.E356*|HSP90AA1_uc001ykw.1_Nonsense_Mutation_p.E55*|HSP90AA1_uc001ykx.1_Nonsense_Mutation_p.E223*	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	234					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	tcttcAGCCTCATCATCGCTT	0.323													1	0	2.80697e-09	0.010729	2.99719e-09	11	26										A	102551299	C	A	102551299	4	1	62	1	0	0	0	0	0	1	0	0	7401	835	29	3	1526	3	HSP90AA1	14	102551299	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10079581	102551299	4798241	327	18252										
HSP90AA1	3320	broad.mit.edu	37	chr14	102552620	102552620	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gagtagaaagtattgatgatCaatgacatcaactgggcaat	10	5	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:102552620C>G	uc001yku.3	-	2	286	c.96G>C	c.(94-96)TTG>TTC	p.L32F	HSP90AA1_uc001ykv.3_Missense_Mutation_p.L154F|HSP90AA1_uc001ykw.1_5'UTR|HSP90AA1_uc001ykx.1_Missense_Mutation_p.L21F	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	32					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	TATTGATGATCAATGACATCA	0.443													0	0	0	0.005443	0	27	71										G	102552620	C	G	102552620	3	3	62	1	0	0	0	0	1	0	0	0	7401	825	29	1	2142	1	HSP90AA1	14	102552620	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1321	102552620	4796920	328	18253										
INF2	64423	broad.mit.edu	37	chr14	105172458	105172458	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggaggagctgctgcgagtctCtggcggggtcgacatgagca	18	9	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105172458C>G	uc001ypb.2	+	6	931	c.788C>G	c.(787-789)TCT>TGT	p.S263C	INF2_uc010tyi.1_Missense_Mutation_p.S263C|INF2_uc001ypc.2_Missense_Mutation_p.S263C|INF2_uc010awz.1_5'Flank	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	263	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGCGAGTCTCTGGCGGGGTC	0.672													0	0	0	0.006214	0	8	14										G	105172458	C	G	105172458	3	3	62	1	0	0	0	0	1	0	0	0	7734	913	32	1	810	1	INF2	14	105172458	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2619838	105172458	2177082	329	18254			6	82		4	4	1761	C		3.072348e-06
INF2	64423	broad.mit.edu	37	chr14	105173276	105173276	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tccccggtgtctgcccagctCctgtcggtgctgcagggcct	13	16	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105173276C>G	uc001ypb.2	+	7	1016	c.873C>G	c.(871-873)CTC>CTG	p.L291L	INF2_uc010tyi.1_Silent_p.L291L|INF2_uc001ypc.2_Silent_p.L291L|INF2_uc010awz.1_5'Flank	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	291	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGCCCAGCTCCTGTCGGTGC	0.706													0	0	0	0.007413	0	15	22										G	105173276	C	G	105173276	2	3	62	1	0	0	0	0	0	0	0	1	7734	842	30	1		1	INF2	14	105173276	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	818	105173276	2176264	330	18255			6	82		4	4	1761	C		3.072348e-06
INF2	64423	broad.mit.edu	37	chr14	105174062	105174062	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctgccaggctcctgtgagttCctgcccccaccacctccacc	7	21	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105174062C>G	uc001ypb.2	+	8	1601	c.1458C>G	c.(1456-1458)TTC>TTG	p.F486L	INF2_uc010tyi.1_Missense_Mutation_p.F486L|INF2_uc001ypc.2_Missense_Mutation_p.F486L|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	486	Pro-rich.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		cctgtgagttcctgcccccac	0.179													0	0	0	0.004672	0	2	0										G	105174062	C	G	105174062	3	3	62	1	0	0	0	0	1	0	0	0	7734	854	30	1	1488	1	INF2	14	105174062	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	786	105174062	2175478	331	18256			6	82		4	4	1761	C		3.072348e-06
INF2	64423	broad.mit.edu	37	chr14	105174218	105174218	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggaggcatggaggaggtcatCgtggcccaggtggaccatgg	19	8	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105174218C>A	uc001ypb.2	+	8	1757	c.1614C>A	c.(1612-1614)ATC>ATA	p.I538I	INF2_uc010tyi.1_Silent_p.I538I|INF2_uc001ypc.2_Silent_p.I538I|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	538					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		AGGAGGTCATCGTGGCCCAGG	0.652													1	0	3.59834e-05	0.001168	3.73279e-05	5	23										A	105174218	C	A	105174218	2	1	62	1	0	0	0	0	0	0	0	1	7734	874	31	3		3	INF2	14	105174218	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	156	105174218	2175322	332	18257			6	82		4	4	1761	C		3.072348e-06
MTMR15	22909	broad.mit.edu	37	chr15	31197525	31197525	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaacgtgtttaaatgtgattCtctaaaggaagagtgcattc	9	5	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:31197525C>G	uc001zff.2	+	2	950	c.659C>G	c.(658-660)TCT>TGT	p.S220C	MTMR15_uc001zfc.3_Missense_Mutation_p.S220C|MTMR15_uc010azw.2_Missense_Mutation_p.S220C|MTMR15_uc001zfd.3_Missense_Mutation_p.S220C|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	220					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		AAATGTGATTCTCTAAAGGAA	0.393								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.010504	0	20	38										G	31197525	C	G	31197525	3	3	62	1	0	0	0	0	1	0	0	0	9943	913	32	1	661	1	MTMR15	15	31197525	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		31197525	71333867	333	18258										
C15orf55	256646	broad.mit.edu	37	chr15	34645971	34645971	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aggctgaggagatgcagattCagaacacacagctgatgaat	12	7	1	6			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:34645971C>A	uc001zif.2	+	4	1044	c.889C>A	c.(889-891)CAG>AAG	p.Q297K	C15orf55_uc010ucc.1_Missense_Mutation_p.Q325K|C15orf55_uc010ucd.1_Missense_Mutation_p.Q315K	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	297						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GATGCAGATTCAGAACACACA	0.542			T	BRD3|BRD4	lethal midline carcinoma								1	0	6.14515e-18	0.01441	6.90293e-18	41	59										A	34645971	C	A	34645971	3	1	62	1	0	0	0	0	1	0	0	0	1803	827	29	3	903	3	C15orf55	15	34645971	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3448446	34645971	67885421	334	18259										
LRRC57	255252	broad.mit.edu	37	chr15	42839461	42839461	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaccttaaagctctagacctGattctggttgaggttgagtt	10	7	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:42839461G>C	uc001zqd.1	-	3	858	c.490C>G	c.(490-492)CAG>GAG	p.Q164E	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Missense_Mutation_p.Q164E	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	164	LRR 6.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		CTCTAGACCTGATTCTGGTTG	0.443													0	0	0	0.010729	0	9	59										C	42839461	G	C	42839461	3	2	62	1	0	0	0	0	1	0	0	0	9013	1299	45	1	241	1	LRRC57	15	42839461	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	8193490	42839461	59691931	335	18260										
DMXL2	23312	broad.mit.edu	37	chr15	51758463	51758463	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcatcactatgaatgctttCatcagaatcatatataacac	3	9	5	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:51758463C>T	uc002abf.2	-	30	7660	c.7435G>A	c.(7435-7437)GAA>AAA	p.E2479K	DMXL2_uc002abd.2_Missense_Mutation_p.E550K|DMXL2_uc010ufy.1_Missense_Mutation_p.E2480K|DMXL2_uc010bfa.2_Missense_Mutation_p.E1843K	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2479						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TGAATGCTTTCATCAGAATCA	0.269													0	0	0	0.01441	0	37	68										T	51758463	C	T	51758463	3	4	62	1	0	0	0	0	1	0	0	0	4595	835	29	1	1731	1	DMXL2	15	51758463	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	8919002	51758463	50772929	336	18261										
SLTM	79811	broad.mit.edu	37	chr15	59191829	59191829	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccatctttatggttcgcattCatctcataatccttgctttc	4	12	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:59191829C>A	uc002afp.2	-	7	985	c.897G>T	c.(895-897)ATG>ATT	p.M299I	SLTM_uc002afo.2_Missense_Mutation_p.M281I|SLTM_uc002afq.2_Intron|SLTM_uc010bgd.2_Intron|SLTM_uc002afr.1_Missense_Mutation_p.M198I	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	299					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GGTTCGCATTCATCTCATAAT	0.448													1	0	1.48734e-19	0.013114	1.70692e-19	37	118										A	59191829	C	A	59191829	3	1	62	1	0	0	0	0	1	0	0	0	14754	826	29	3	2267	3	SLTM	15	59191829	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7433366	59191829	43339563	337	18262										
RBPMS2	348093	broad.mit.edu	37	chr15	65040670	65040670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagttgggtaggtgaacgcaGcatgggagatggctggggtc	19	6	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65040670G>A	uc002anq.2	-	6	767	c.515C>T	c.(514-516)GCT>GTT	p.A172V		NM_194272	NP_919248	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	172							nucleic acid binding|nucleotide binding				0						GGTGAACGCAGCATGGGAGAT	0.622													0	0	0	0.007291	0	24	51										A	65040670	G	A	65040670	3	1	62	1	0	0	0	0	1	0	0	0	13164	971	34	2	122	2	RBPMS2	15	65040670	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	5848841	65040670	37490722	338	18263										
IGDCC4	57722	broad.mit.edu	37	chr15	65680830	65680830	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atcacatcctgcaggcgggaGaaaggcccaggtcccacctc	11	15	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65680830G>C	uc002aou.1	-	16	3012	c.2802C>G	c.(2800-2802)TTC>TTG	p.F934L	IGDCC4_uc002aot.1_Missense_Mutation_p.F522L	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	934	Extracellular (Potential).|Fibronectin type-III 5.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GCAGGCGGGAGAAAGGCCCAG	0.602													0	0	0	0.01441	0	59	169										C	65680830	G	C	65680830	3	2	62	1	0	0	0	0	1	0	0	0	7569	933	33	1	970	1	IGDCC4	15	65680830	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	640160	65680830	36850562	339	18264										
IGDCC4	57722	broad.mit.edu	37	chr15	65693281	65693281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccccctggtggacgccaggGaccctggcgagaagacagac	15	14	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65693281G>A	uc002aou.1	-	5	914	c.704C>T	c.(703-705)TCC>TTC	p.S235F		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	235	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGACGCCAGGGACCCTGGCGA	0.408											OREG0023196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	29	62										A	65693281	G	A	65693281	3	1	62	1	0	0	0	0	1	0	0	0	7569	1174	41	1	3112	1	IGDCC4	15	65693281	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	12451	65693281	36838111	340	18265										
LCTL	197021	broad.mit.edu	37	chr15	66845384	66845384	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atatagccatttagaccccaGatctggccagtttgggtcaa	9	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:66845384G>T	uc002aqc.2	-	9	1267	c.1135C>A	c.(1135-1137)CTG>ATG	p.L379M	LCTL_uc002aqd.3_Missense_Mutation_p.L206M|LCTL_uc010bhw.2_Missense_Mutation_p.L77M	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	379	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						TTAGACCCCAGATCTGGCCAG	0.493													1	0	4.96729e-08	0.008871	5.26533e-08	16	100										T	66845384	G	T	66845384	3	4	62	1	0	0	0	0	1	0	0	0	8694	933	33	3	588	3	LCTL	15	66845384	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1152103	66845384	35686008	341	18266										
SMAD3	4088	broad.mit.edu	37	chr15	67457371	67457371	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtgagttcgccttcaatatGaagaaggacgaggtctgcgt	13	7	2	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:67457371G>A	uc002aqj.2	+	2	643	c.345G>A	c.(343-345)ATG>ATA	p.M115I	SMAD3_uc010ujr.1_Missense_Mutation_p.M10I|SMAD3_uc010ujs.1_Missense_Mutation_p.M71I|SMAD3_uc010ujt.1_5'Flank	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	115	MH1.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCTTCAATATGAAGAAGGACG	0.602													0	0	0	0.007413	0	15	99										A	67457371	G	A	67457371	3	1	62	1	0	0	0	0	1	0	0	0	14759	1290	45	1	429	1	SMAD3	15	67457371	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	611987	67457371	35074021	342	18267										
HMG20A	10363	broad.mit.edu	37	chr15	77770687	77770687	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aatccaacatggagtttgagGagaggaatgcagccctgcaa	12	8	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:77770687G>T	uc002bcr.2	+	9	943	c.742G>T	c.(742-744)GAG>TAG	p.E248*	HMG20A_uc002bcs.2_Nonsense_Mutation_p.E248*	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	248	Potential.				chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGAGTTTGAGGAGAGGAATGC	0.557													1	0	4.87955e-14	0.005443	5.34733e-14	26	64										T	77770687	G	T	77770687	4	4	62	1	0	0	0	0	0	1	0	0	7221	1175	41	3	768	3	HMG20A	15	77770687	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10313316	77770687	24760705	343	18268										
AKAP13	11214	broad.mit.edu	37	chr15	86064775	86064775	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtacaagtactcggaaggtCagttctgatacattggagac	11	7	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:86064775C>T	uc002blv.1	+	3	320	c.150C>T	c.(148-150)GTC>GTT	p.V50V	AKAP13_uc002bls.2_Silent_p.V50V|AKAP13_uc002blt.1_Silent_p.V50V|AKAP13_uc002blu.1_Silent_p.V50V	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	50					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CTCGGAAGGTCAGTTCTGATA	0.418													0	0	0	0.008871	0	17	103										T	86064775	C	T	86064775	2	4	62	1	0	0	0	0	0	0	0	1	449	813	29	1		1	AKAP13	15	86064775	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	8294088	86064775	16466617	344	18269										
NTRK3	4916	broad.mit.edu	37	chr15	88576243	88576243	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtggtgcagtgggctggctGagtcctcctcaccactgatg	14	11	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:88576243G>C	uc002bme.1	-	13	1592	c.1430C>G	c.(1429-1431)TCA>TGA	p.S477*	NTRK3_uc002bmh.2_Nonsense_Mutation_p.S469*|NTRK3_uc002bmf.1_Nonsense_Mutation_p.S477*|NTRK3_uc010upl.1_Nonsense_Mutation_p.S379*|NTRK3_uc010bnh.1_Nonsense_Mutation_p.S469*|NTRK3_uc002bmg.2_Nonsense_Mutation_p.S477*|NTRK3_uc010bni.2_RNA	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	477	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGGGCTGGCTGAGTCCTCCTC	0.622			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.000602	0	5	12										C	88576243	G	C	88576243	4	2	62	1	0	0	0	0	0	1	0	0	10708	1294	45	1	1379	1	NTRK3	15	88576243	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2511468	88576243	13955149	345	18270										
ANPEP	290	broad.mit.edu	37	chr15	90348336	90348336	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccattggatgcctgcttctcCacgtagtcgaactcactgac	8	14	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90348336C>T	uc002bop.3	-	4	1162	c.870G>A	c.(868-870)GTG>GTA	p.V290V		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	290	Extracellular.|Interaction with HCoV-229E.|Metalloprotease.			DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection.|DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity.|DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection.	angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCTGCTTCTCCACGTAGTCGA	0.562													0	0	0	0.01441	0	45	105										T	90348336	C	T	90348336	2	4	62	1	0	0	0	0	0	0	0	1	710	581	21	2		2	ANPEP	15	90348336	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1772093	90348336	12183056	346	18271										
ANPEP	290	broad.mit.edu	37	chr15	90348636	90348636	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggccttcatggccggctcatCgaagcatgggaaggacttcc	13	12	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90348636C>G	uc002bop.3	-	3	965	c.673G>C	c.(673-675)GAT>CAT	p.D225H		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	225	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCCGGCTCATCGAAGCATGGG	0.607													0	0	0	0.00632	0	24	34										G	90348636	C	G	90348636	3	3	62	1	0	0	0	0	1	0	0	0	710	884	31	1	2306	1	ANPEP	15	90348636	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	300	90348636	12182756	347	18272										
IQGAP1	8826	broad.mit.edu	37	chr15	91020904	91020904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgatgttttataggtcgaagGtagatcagattcaagagatt	11	3	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91020904G>A	uc002bpl.1	+	26	3213	c.3112G>A	c.(3112-3114)GTA>ATA	p.V1038I		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1038	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TAGGTCGAAGGTAGATCAGAT	0.393													0	0	0	0.003163	0	15	68										A	91020904	G	A	91020904	3	1	62	1	0	0	0	0	1	0	0	0	7814	1261	44	2	3214	2	IQGAP1	15	91020904	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	672268	91020904	11510488	348	18273										
IQGAP1	8826	broad.mit.edu	37	chr15	91020921	91020921	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaggtagatcagattcaagaGattgtgacaggaaatcctac	10	6	2	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91020921G>C	uc002bpl.1	+	26	3230	c.3129G>C	c.(3127-3129)GAG>GAC	p.E1043D		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1043	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AGATTCAAGAGATTGTGACAG	0.413													0	0	0	0.010504	0	20	72										C	91020921	G	C	91020921	3	2	62	1	0	0	0	0	1	0	0	0	7814	933	33	1	3231	1	IQGAP1	15	91020921	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	17	91020921	11510471	349	18274										
SV2B	9899	broad.mit.edu	37	chr15	91835762	91835762	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccttcgactgccagagactCgagaacaggtcctgatgtga	11	12	0	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91835762C>G	uc002bqv.2	+	12	2423	c.2032C>G	c.(2032-2034)CGA>GGA	p.R678G	SV2B_uc010uqv.1_Missense_Mutation_p.R527G|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	678	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GCCAGAGACTCGAGAACAGGT	0.512													0	0	0	0.012319	0	18	105										G	91835762	C	G	91835762	3	3	62	1	0	0	0	0	1	0	0	0	15415	876	31	1	2078	1	SV2B	15	91835762	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	814841	91835762	10695630	350	18275										
CHD2	1106	broad.mit.edu	37	chr15	93558002	93558002	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcaggctccagccgggactCtctgatatctcagtcccata	8	15	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:93558002C>G	uc002bsp.2	+	37	5344	c.4769C>G	c.(4768-4770)TCT>TGT	p.S1590C	CHD2_uc002bso.1_Missense_Mutation_p.S1590C	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1590					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGCCGGGACTCTCTGATATCT	0.512													0	0	0	0.01441	0	57	102										G	93558002	C	G	93558002	3	3	62	1	0	0	0	0	1	0	0	0	3325	913	32	1	4915	1	CHD2	15	93558002	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1722240	93558002	8973390	351	18276										
PIGQ	9091	broad.mit.edu	37	chr16	624461	624461	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaggaccaggtcatgctcatCttctatgaccagcgccaggt	11	12	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:624461C>T	uc002cho.2	+	2	489	c.387C>T	c.(385-387)ATC>ATT	p.I129I	PIGQ_uc010bqw.2_Silent_p.I129I|PIGQ_uc002chm.2_Silent_p.I129I|PIGQ_uc002chn.2_Silent_p.I129I|PIGQ_uc010uui.1_Silent_p.I143I	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	129					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				TCATGCTCATCTTCTATGACC	0.692													0	0	0	0.00308	0	6	12										T	624461	C	T	624461	2	4	62	1	0	0	0	0	0	0	0	1	11896	903	32	1		1	PIGQ	16	624461	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		624461	89730292	352	18277										
FAM195A	84331	broad.mit.edu	37	chr16	697532	697532	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccacgaggagaatgtccgcTttgtgtccgaaggtagcgag	14	10	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:697532T>A	uc002cic.1	+	3	441	c.298T>A	c.(298-300)TTT>ATT	p.F100I	FAM195A_uc002cid.1_Intron|FAM195A_uc002cie.2_Silent_p.A28A|FAM195A_uc002cif.1_RNA|WDR90_uc002cig.1_5'Flank|WDR90_uc002cih.1_5'Flank|WDR90_uc002cii.1_5'Flank|WDR90_uc002cij.1_5'Flank	NM_138418	NP_612427	Q9BUT9	F195A_HUMAN	hypothetical protein LOC84331	100											0						GAATGTCCGCTTTGTGTCCGA	0.637													0	0	0	0.006214	0	7	23										A	697532	T	A	697532	3	1	62	1	0	0	0	0	1	0	0	0	5527	1609	56	5	308	5	FAM195A	16	697532	Missense_Mutation	SNP	T	TCGA-DK-A3IT-01A-31D-A20D-08	73071	697532	89657221	353	18278										
MSLN	10232	broad.mit.edu	37	chr16	814666	814666	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgcgctgtctggctcaccGgctctctgagccccccgagg	13	17	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:814666G>A	uc002cjw.1	+	6	371	c.320G>A	c.(319-321)CGG>CAG	p.R107Q	MSLN_uc002cjt.1_Missense_Mutation_p.R107Q|MSLN_uc002cju.1_Missense_Mutation_p.R107Q|MSLN_uc010brd.1_Missense_Mutation_p.R106Q|MSLN_uc002cjv.1_Missense_Mutation_p.R107Q|MSLN_uc002cjx.1_Missense_Mutation_p.R107Q|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	107					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CTGGCTCACCGGCTCTCTGAG	0.682													0	0	0	0.01441	0	53	127										A	814666	G	A	814666	3	1	62	1	0	0	0	0	1	0	0	0	9881	1116	39	2	338	2	MSLN	16	814666	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	117134	814666	89540087	354	18279										
CORO7	79585	broad.mit.edu	37	chr16	4390379	4390379	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcctggattttgagttcctCatccaggcgctcctttgcgc	11	13	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:4390379C>T	uc002cwf.2	-	31	3531	c.3088G>A	c.(3088-3090)GAG>AAG	p.E1030K	CORO7_uc002cwe.2_RNA|TIMM16_uc002cwd.2_Missense_Mutation_p.E107K	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	Error:Variant_position_missing_in_P57737_after_alignment						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TTGAGTTCCTCATCCAGGCGC	0.622													0	0	0	0.004656	0	23	41										T	4390379	C	T	4390379	3	4	62	1	0	0	0	0	1	0	0	0	3759	835	29	1		1	CORO7	16	4390379	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3575713	4390379	85964374	355	18280										
ZKSCAN2	342357	broad.mit.edu	37	chr16	25251339	25251339	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttctccgatgttctcgaaatCtcgtacagttattgaaactt	6	9	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:25251339C>G	uc002dod.3	-	7	3109	c.2702G>C	c.(2701-2703)AGA>ACA	p.R901T	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.R697T	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	901	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TTCTCGAAATCTCGTACAGTT	0.458													0	0	0	0.003163	0	13	29										G	25251339	C	G	25251339	3	3	62	1	0	0	0	0	1	0	0	0	17684	913	32	1	205	1	ZKSCAN2	16	25251339	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	20860960	25251339	65103414	356	18281										
APOB48R	55911	broad.mit.edu	37	chr16	28508751	28508751	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gggactcgaaagaaaaggaaGaggcagcagcaggagagcat	16	6	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:28508751G>A	uc002dqb.1	+	3	2372	c.2362G>A	c.(2362-2364)GAG>AAG	p.E788K	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.E326K	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	788	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						AGAAAAGGAAGAGGCAGCAGC	0.572													0	0	0	0.001984	0	6	10										A	28508751	G	A	28508751	3	1	62	1	0	0	0	0	1	0	0	0	786	943	33	1	2372	1	APOB48R	16	28508751	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3257412	28508751	61846002	357	18282										
ITGAX	3687	broad.mit.edu	37	chr16	31391116	31391116	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agggacctgcctgtcagcatCaacttctgggtgcctgtgga	13	11	3	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:31391116C>T	uc002ebu.1	+	25	2974	c.2907C>T	c.(2905-2907)ATC>ATT	p.I969I	ITGAX_uc002ebt.2_Silent_p.I969I	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	969	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTGTCAGCATCAACTTCTGGG	0.617													0	0	0	0.010729	0	8	24										T	31391116	C	T	31391116	2	4	62	1	0	0	0	0	0	0	0	1	7889	816	29	1		1	ITGAX	16	31391116	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2882365	31391116	58963637	358	18283										
CMTM2	146225	broad.mit.edu	37	chr16	66620940	66620940	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgcttgtgcgttccttgtggGagccgtggtctttgctgtga	15	8	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:66620940G>A	uc002ept.2	+	3	645	c.485G>A	c.(484-486)GGA>GAA	p.G162E	CMTM2_uc010cdu.2_Missense_Mutation_p.G109E	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	162	MARVEL.|Helical; (Potential).				chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		TTCCTTGTGGGAGCCGTGGTC	0.522													0	0	0	0.00499	0	14	87										A	66620940	G	A	66620940	3	1	62	1	0	0	0	0	1	0	0	0	3583	1174	41	1	495	1	CMTM2	16	66620940	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	35229824	66620940	23733813	359	18284										
EXOC3L	283849	broad.mit.edu	37	chr16	67218811	67218811	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caagaagctctcaccaaactGaggaaaagctgctgaagctg	10	10	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67218811G>A	uc002erx.1	-	12	2140	c.1899C>T	c.(1897-1899)CTC>CTT	p.L633L	KIAA0895L_uc002ert.2_5'Flank|KIAA0895L_uc002eru.2_5'Flank|EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Silent_p.L284L|EXOC3L_uc002ery.1_Silent_p.L535L|EXOC3L_uc010vje.1_Silent_p.L530L	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	633					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		TCACCAAACTGAGGAAAAGCT	0.687													0	0	0	0.004672	0	3	22										A	67218811	G	A	67218811	2	1	62	1	0	0	0	0	0	0	0	1	5304	1277	45	1		1	EXOC3L	16	67218811	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	597871	67218811	23135942	360	18285										
AGRP	181	broad.mit.edu	37	chr16	67517183	67517183	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cacactgacctgggagctctGggagcagggcctggtcaggc	16	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67517183G>C	uc002etg.1	-	2	419	c.119C>G	c.(118-120)CCA>CGA	p.P40R	ATP6V0D1_uc002ete.1_5'Flank|ATP6V0D1_uc010vjo.1_5'Flank	NM_001138	NP_001129	O00253	AGRP_HUMAN	agouti related protein homolog isoform 1	40					hormone-mediated signaling pathway|neuropeptide signaling pathway|regulation of feeding behavior	extracellular space|Golgi lumen	neuropeptide hormone activity				0		Acute lymphoblastic leukemia(13;0.00263)|all_hematologic(13;0.0274)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0717)|Epithelial(162;0.16)		TGGGAGCTCTGGGAGCAGGGC	0.637													0	0	0	0.004672	0	3	4										C	67517183	G	C	67517183	3	2	62	1	0	0	0	0	1	0	0	0	398	1348	47	4	291	4	AGRP	16	67517183	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	298372	67517183	22837570	361	18286										
THAP11	57215	broad.mit.edu	37	chr16	67876898	67876898	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagactgcccagctgcagccGaacctggtatctgcttccgc	10	16	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67876898G>T	uc002euo.2	+	1	686	c.441G>T	c.(439-441)CCG>CCT	p.P147P	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		AGCTGCAGCCGAACCTGGTAT	0.468													1	0	2.56175e-15	0.01441	2.83935e-15	35	182										T	67876898	G	T	67876898	2	4	62	1	0	0	0	0	0	0	0	1	15840	1045	37	3		3	THAP11	16	67876898	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	359715	67876898	22477855	362	18287										
EDC4	23644	broad.mit.edu	37	chr16	67917616	67917616	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcatctgaccttggcactcGaactgacctcaagctcaggt	10	13	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67917616G>C	uc002eur.2	+	28	4161	c.3995G>C	c.(3994-3996)CGA>CCA	p.R1332P	EDC4_uc010cer.2_Missense_Mutation_p.R951P|EDC4_uc002eus.2_Missense_Mutation_p.R1062P|EDC4_uc002eut.1_3'UTR|NRN1L_uc002euu.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	1332					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTTGGCACTCGAACTGACCTC	0.617											OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	42	220										C	67917616	G	C	67917616	3	2	62	1	0	0	0	0	1	0	0	0	4908	1058	37	1	4105	1	EDC4	16	67917616	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	40718	67917616	22437137	363	18288										
SLC7A6	9057	broad.mit.edu	37	chr16	68308901	68308901	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggccattggtgggctcttctCtgttgtgggtgccctttgtt	14	9	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:68308901C>G	uc002evt.1	+	4	581	c.272C>G	c.(271-273)TCT>TGT	p.S91C	SLC7A6_uc010cfb.1_RNA|SLC7A6_uc002evu.1_Missense_Mutation_p.S91C|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	91	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GGGCTCTTCTCTGTTGTGGGT	0.547													0	0	0	0.010771	0	33	48										G	68308901	C	G	68308901	3	3	62	1	0	0	0	0	1	0	0	0	14701	913	32	1	274	1	SLC7A6	16	68308901	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	391285	68308901	22045852	364	18289										
HYDIN	54768	broad.mit.edu	37	chr16	71008159	71008159	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cacttcaaatatttccgtttCacaatgaggtagattcttta	5	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:71008159C>G	uc002ezr.2	-	33	5079	c.4951G>C	c.(4951-4953)GAA>CAA	p.E1651Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1652										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTTCCGTTTCACAATGAGGT	0.428													0	0	0	0.000602	0	4	20										G	71008159	C	G	71008159	3	3	62	1	0	0	0	0	1	0	0	0	7467	835	29	1	10627	1	HYDIN	16	71008159	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2699258	71008159	19346594	365	18290										
GLG1	2734	broad.mit.edu	37	chr16	74511362	74511362	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcacttatcctggagggcagGatccagcttgacatccatgg	12	11	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:74511362G>C	uc002fcy.3	-	12	1947	c.1897C>G	c.(1897-1899)CCT>GCT	p.P633A	GLG1_uc002fcx.2_Missense_Mutation_p.P633A|GLG1_uc002fcw.3_Missense_Mutation_p.P622A|GLG1_uc002fcz.3_Missense_Mutation_p.P50A	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	633	Cys-rich GLG1 9.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						TGGAGGGCAGGATCCAGCTTG	0.483													0	0	0	0.01441	0	84	58										C	74511362	G	C	74511362	3	2	62	1	0	0	0	0	1	0	0	0	6436	1174	41	1	1782	1	GLG1	16	74511362	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3503203	74511362	15843391	366	18291										
RFWD3	55159	broad.mit.edu	37	chr16	74685877	74685877	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caacccctccatactctgcaGagctgtcactgtcagaatca	6	15	4	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:74685877G>A	uc002fda.2	-	3	760	c.662C>T	c.(661-663)TCT>TTT	p.S221F	RFWD3_uc010cgq.2_Missense_Mutation_p.S221F	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	221				S -> P (in Ref. 1; BAF83889).	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						ATACTCTGCAGAGCTGTCACT	0.468													0	0	0	0.01441	0	82	53										A	74685877	G	A	74685877	3	1	62	1	0	0	0	0	1	0	0	0	13261	942	33	1	1706	1	RFWD3	16	74685877	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	174515	74685877	15668876	367	18292										
ADAT1	23536	broad.mit.edu	37	chr16	75642774	75642774	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aacaagtcgacctgggctatCagccctttttgcctgcaccg	9	14	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:75642774C>G	uc002feo.1	-	8	1258	c.1156G>C	c.(1156-1158)GAT>CAT	p.D386H	ADAT1_uc002fep.1_Missense_Mutation_p.D237H	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	386	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						CCTGGGCTATCAGCCCTTTTT	0.512													0	0	0	0.005443	0	23	57										G	75642774	C	G	75642774	3	3	62	1	0	0	0	0	1	0	0	0	284	826	29	1	368	1	ADAT1	16	75642774	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	956897	75642774	14711979	368	18293										
TERF2IP	54386	broad.mit.edu	37	chr16	75681873	75681873	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gacggcagctccatgtccttCtacgtgcggcccagcccggc	12	17	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:75681873C>G	uc002fet.1	+	1	190	c.93C>G	c.(91-93)TTC>TTG	p.F31L	KARS_uc002fer.2_5'Flank|KARS_uc002feq.2_5'Flank|KARS_uc002fes.2_5'Flank|KARS_uc010cha.1_Intron	NM_018975	NP_061848	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting	31					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1						CCATGTCCTTCTACGTGCGGC	0.682													0	0	0	0.001855	0	12	52										G	75681873	C	G	75681873	3	3	62	1	0	0	0	0	1	0	0	0	15760	912	32	1	95	1	TERF2IP	16	75681873	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	39099	75681873	14672880	369	18294										
MLYCD	23417	broad.mit.edu	37	chr16	83948929	83948929	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atcaactggatggcggatgtGagcctcagaggcatcaccgg	14	10	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:83948929G>T	uc002fgz.2	+	5	1337	c.1317G>T	c.(1315-1317)GTG>GTT	p.V439V		NM_012213	NP_036345	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase precursor	439					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity				0						TGGCGGATGTGAGCCTCAGAG	0.637													1	0	1.799e-87	0.01441	2.11455e-87	121	71										T	83948929	G	T	83948929	2	4	62	1	0	0	0	0	0	0	0	1	9638	1277	45	3		3	MLYCD	16	83948929	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	8267056	83948929	6405824	370	18295										
FOXC2	2303	broad.mit.edu	37	chr16	86601504	86601504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccacctcaaggagccgccccCggcggcgtccaagggcgccc	13	20	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:86601504C>T	uc002fjq.2	+	1	648	c.563C>T	c.(562-564)CCG>CTG	p.P188L		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	188					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						GAGCCGCCCCCGGCGGCGTCC	0.701									Late-onset_Hereditary_Lymphedema				0	0	0	0.008291	0	7	18										T	86601504	C	T	86601504	3	4	62	1	0	0	0	0	1	0	0	0	5995	652	23	2	565	2	FOXC2	16	86601504	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2652575	86601504	3753249	371	18296										
SPATA2L	124044	broad.mit.edu	37	chr16	89763774	89763774	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccggggctgttgtagagcaGagtgtccatctgtgcacgct	14	11	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:89763774G>C	uc002foj.2	-	3	1308	c.1243C>G	c.(1243-1245)CTG>GTG	p.L415V	SPATA2L_uc002fok.2_Intron	NM_152339	NP_689552	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	415											0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		TTGTAGAGCAGAGTGTCCATC	0.687													0	0	0	0.009096	0	4	14										C	89763774	G	C	89763774	3	2	62	1	0	0	0	0	1	0	0	0	15008	933	33	1	35	1	SPATA2L	16	89763774	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3162270	89763774	590979	372	18297										
FANCA	2175	broad.mit.edu	37	chr16	89807249	89807249	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acgacagcaggcccatcaagGagaagaagaaaaggaaaacc	11	9	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:89807249G>T	uc002fou.1	-	38	3833	c.3791C>A	c.(3790-3792)TCC>TAC	p.S1264Y	ZNF276_uc010ciq.2_3'UTR|ZNF276_uc002foq.3_3'UTR|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_3'UTR|ZNF276_uc010cis.2_3'UTR|ZNF276_uc002fos.3_3'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_3'UTR|FANCA_uc010vpn.1_Missense_Mutation_p.S1264Y|FANCA_uc010vpo.1_Missense_Mutation_p.S350Y	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1264					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GCCCATCAAGGAGAAGAAGAA	0.453			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	1.2644e-06	0.010504	1.32581e-06	18	22										T	89807249	G	T	89807249	3	4	62	1	0	0	0	0	1	0	0	0	5662	1174	41	3	600	3	FANCA	16	89807249	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	43475	89807249	547504	373	18298										
ZZEF1	23140	broad.mit.edu	37	chr17	3984727	3984727	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccaggacttcactgatgttCatcttggccaggtcgttctt	10	11	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:3984727C>T	uc002fxe.2	-	18	2836	c.2772G>A	c.(2770-2772)ATG>ATA	p.M924I	ZZEF1_uc002fxk.1_Missense_Mutation_p.M925I	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	924							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CACTGATGTTCATCTTGGCCA	0.498													0	0	0	0.01441	0	44	50										T	3984727	C	T	3984727	3	4	62	1	0	0	0	0	1	0	0	0	18252	826	29	1	6265	1	ZZEF1	17	3984727	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		3984727	77210483	374	18299										
ZZEF1	23140	broad.mit.edu	37	chr17	4045961	4045961	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccagcgaaacaacgcgccgcGatgcctcgacaccagcgact	10	17	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:4045961G>A	uc002fxe.2	-	1	293	c.229C>T	c.(229-231)CGC>TGC	p.R77C	ZZEF1_uc002fxk.1_Missense_Mutation_p.R77C|CYB5D2_uc002fxm.3_5'Flank|CYB5D2_uc010cko.2_5'Flank|CYB5D2_uc002fxl.3_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	77							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AACGCGCCGCGATGCCTCGAC	0.721													0	0	0	0.008291	0	8	11										A	4045961	G	A	4045961	3	1	62	1	0	0	0	0	1	0	0	0	18252	1058	37	1	8876	1	ZZEF1	17	4045961	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	61234	4045961	77149249	375	18300										
USP6	9098	broad.mit.edu	37	chr17	5041507	5041507	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atgaacgatgacaccgtgctCaagcatcttagggcctctac	9	12	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:5041507C>T	uc002gau.1	+	21	3247	c.1017C>T	c.(1015-1017)CTC>CTT	p.L339L	USP6_uc002gav.1_Silent_p.L339L|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	339					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						ACACCGTGCTCAAGCATCTTA	0.577			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								0	0	0	0.010818	0	30	93										T	5041507	C	T	5041507	2	4	62	1	0	0	0	0	0	0	0	1	17083	813	29	1		1	USP6	17	5041507	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	995546	5041507	76153703	376	18301										
PITPNM3	83394	broad.mit.edu	37	chr17	6374547	6374547	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctcgctgtgggagctcccctCgctcatcctccgtcctgggc	11	18	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:6374547C>A	uc002gdd.3	-	12	1709	c.1558G>T	c.(1558-1560)GAG>TAG	p.E520*	PITPNM3_uc010cln.2_Nonsense_Mutation_p.E484*|PITPNM3_uc010clm.2_Nonsense_Mutation_p.E3*|PITPNM3_uc002gdc.3_Nonsense_Mutation_p.E111*	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	520	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GAGCTCCCCTCGCTCATCCTC	0.687													1	0	0.00448238	0.004482	0.00460075	7	18										A	6374547	C	A	6374547	4	1	62	1	0	0	0	0	0	1	0	0	11952	893	31	3	1402	3	PITPNM3	17	6374547	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1333040	6374547	74820663	377	18302										
ASGR2	433	broad.mit.edu	37	chr17	7010563	7010563	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccctaccgttgctgtggagGagctccatctggcaggccac	12	15	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:7010563G>A	uc002gep.3	-	6	763	c.498C>T	c.(496-498)CTC>CTT	p.L166L	ASGR2_uc010vtk.1_Silent_p.L3L|ASGR2_uc002gem.1_Silent_p.L105L|ASGR2_uc002gen.1_Silent_p.L147L|ASGR2_uc002geo.1_Silent_p.L161L|ASGR2_uc002ger.3_Silent_p.L166L|ASGR2_uc002geq.3_Silent_p.L142L	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	166	Extracellular (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	TGCTGTGGAGGAGCTCCATCT	0.642													0	0	0	0.010729	0	10	14										A	7010563	G	A	7010563	2	1	62	1	0	0	0	0	0	0	0	1	1040	1161	41	1		1	ASGR2	17	7010563	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	636016	7010563	74184647	378	18303										
MYH3	4621	broad.mit.edu	37	chr17	10539066	10539067	+	Missense_Mutation	DNP	CC	CC	TT													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtgtaccttgttctcttcctCcagctgcctcttgagctctt							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:10539066_10539067CC>TT	uc002gmq.1	-	28	4037_4038	c.3960_3961GG>AA	c.(3958-3963)CTGGAG>CTAAAG	p.E1321K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1321	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCTCTTCCTCCAGCTGCCTCT	0.426													0	0	0	0.004672	0	52	77										TT	10539067	CC	TT	10539066	3	4	62	1	0	0	0	0	1	0	0	0	10036	864	30	1	1913	1	MYH3	17	10539066	Missense_Mutation	DNP	CC	TCGA-DK-A3IT-01A-31D-A20D-08	3528503	10539066	70656144	379	18304										
PIP4K2B	8396	broad.mit.edu	37	chr17	36935741	36935741	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtcaggcggtacatgcccagGaactgtggcaaaagcgtgtt	14	9	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:36935741G>C	uc002hqs.2	-	5	1030	c.549C>G	c.(547-549)TTC>TTG	p.F183L	PIP4K2B_uc010wdt.1_Missense_Mutation_p.F183L|PIP4K2B_uc010wdu.1_Missense_Mutation_p.F119L	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	183	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						ACATGCCCAGGAACTGTGGCA	0.522													0	0	0	0.00499	0	17	42										C	36935741	G	C	36935741	3	2	62	1	0	0	0	0	1	0	0	0	11937	1165	41	1	725	1	PIP4K2B	17	36935741	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	26396675	36935741	44259469	380	18305										
MED24	9862	broad.mit.edu	37	chr17	38192035	38192035	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctggacacacaggtcccgaGaaaagtcatcaaactgtgga	10	11	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38192035G>A	uc002htt.2	-	5	579	c.266C>T	c.(265-267)TCT>TTT	p.S89F	MED24_uc010wes.1_5'Flank|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.S114F|MED24_uc002htu.2_Missense_Mutation_p.S76F|MED24_uc010cwn.2_Missense_Mutation_p.S76F|MED24_uc010weu.1_Intron|MED24_uc010wev.1_Missense_Mutation_p.S39F|MED24_uc010wew.1_Missense_Mutation_p.S18F|MED24_uc010wex.1_Intron|MED24_uc010wez.1_5'Flank|MED24_uc010wfa.1_Missense_Mutation_p.S39F|MED24_uc010wfb.1_Missense_Mutation_p.S101F|MED24_uc010wfc.1_Missense_Mutation_p.S26F	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	89					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					CAGGTCCCGAGAAAAGTCATC	0.532													0	0	0	0.004482	0	8	47										A	38192035	G	A	38192035	3	1	62	1	0	0	0	0	1	0	0	0	9442	942	33	1	2791	1	MED24	17	38192035	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1256294	38192035	43003175	381	18306										
NR1D1	9572	broad.mit.edu	37	chr17	38253600	38253600	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gttgtcactatagagggattCagggctggtgcggcttgggg	18	6	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38253600C>G	uc002htz.1	-	2	714	c.88G>C	c.(88-90)GAA>CAA	p.E30Q	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_5'Flank	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	30					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					TAGAGGGATTCAGGGCTGGTG	0.587													0	0	0	0.010504	0	17	22										G	38253600	C	G	38253600	3	3	62	1	0	0	0	0	1	0	0	0	10615	835	29	1	1784	1	NR1D1	17	38253600	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	61565	38253600	42941610	382	18307										
CASC3	22794	broad.mit.edu	37	chr17	38297460	38297460	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtcttctgctttctttcagGagagtgaagatggcattgaa	11	6	4	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38297460G>T	uc010cwt.1	+	2	527	c.232G>T	c.(232-234)GAG>TAG	p.E78*	CASC3_uc010cws.1_Nonsense_Mutation_p.E78*|CASC3_uc002hue.2_Nonsense_Mutation_p.E78*	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	78					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						TTTCTTTCAGGAGAGTGAAGA	0.403													1	0	2.6465e-34	0.01441	3.09821e-34	59	86										T	38297460	G	T	38297460	4	4	62	1	0	0	0	0	0	1	0	0	2661	1188	41	3	238	3	CASC3	17	38297460	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	43860	38297460	42897750	383	18308										
TOP2A	7153	broad.mit.edu	37	chr17	38569453	38569453	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acttatttacttgcctgtttGaacattttcttgtattctct	4	8	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38569453G>C	uc002huq.2	-	6	696	c.570C>G	c.(568-570)TTC>TTG	p.F190L	TOP2A_uc002hur.1_5'Flank	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	190					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTGCCTGTTTGAACATTTTCT	0.328													0	0	0	0.004672	0	2	5										C	38569453	G	C	38569453	3	2	62	1	0	0	0	0	1	0	0	0	16362	1281	45	1	4145	1	TOP2A	17	38569453	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	271993	38569453	42625757	384	18309										
KRT12	3859	broad.mit.edu	37	chr17	39017927	39017927	+	Missense_Mutation	SNP	C	C	T													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaaattttacattagttcttCaatttcctgaacttgagatg							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:39017927C>T	uc002hvk.2	-	8	1495	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	491	Tail.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				ATTAGTTCTTCAATTTCCTGA	0.373													0	0	0	0.003163	0	9	57										T	39017927	C	T	39017927	3	4	62	1	0	0	0	0	1	0	0	0	8449	835	29	1	17	1	KRT12	17	39017927	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	448474	39017927	42177283	385	18310	89	2								
KRT12	3859	broad.mit.edu	37	chr17	39017933	39017933	+	Nonsense_Mutation	SNP	C	C	A													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttacattagttcttcaatttCctgaacttgagatgagacca							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:39017933C>A	uc002hvk.2	-	8	1489	c.1465G>T	c.(1465-1467)GAA>TAA	p.E489*		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	489	Tail.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				TCTTCAATTTCCTGAACTTGA	0.368													1	0	6.31663e-08	0.003163	6.67136e-08	11	65										A	39017933	C	A	39017933	4	1	62	1	0	0	0	0	0	1	0	0	8449	864	30	3	23	3	KRT12	17	39017933	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6	39017933	42177277	386	18311	89	2								
FAM134C	162427	broad.mit.edu	37	chr17	40733844	40733844	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctctgcctcagtggctcctaGaactggcagggtccagctga	12	13	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:40733844G>C	uc002ial.2	-	9	1491	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	FAM134C_uc010wgq.1_Missense_Mutation_p.S263C|FAM134C_uc002iam.1_Missense_Mutation_p.S263C|FAM134C_uc010cyk.1_Missense_Mutation_p.S366C	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	463						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		GTGGCTCCTAGAACTGGCAGG	0.547													0	0	0	0.007413	0	16	34										C	40733844	G	C	40733844	3	2	62	1	0	0	0	0	1	0	0	0	5447	942	33	1	16	1	FAM134C	17	40733844	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1715911	40733844	40461366	387	18312										
ADAM11	4185	broad.mit.edu	37	chr17	42849819	42849819	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cctccaaaccggccgaggctGagaaggaaaaggcaggtacg	14	11	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:42849819G>C	uc002ihh.2	+	8	663	c.663G>C	c.(661-663)CTG>CTC	p.L221L	ADAM11_uc010wjd.1_Missense_Mutation_p.E23Q	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	221					integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GGCCGAGGCTGAGAAGGAAAA	0.706													0	0	0	0.004672	0	3	7										C	42849819	G	C	42849819	2	2	62	1	0	0	0	0	0	0	0	1	235	1277	45	1		1	ADAM11	17	42849819	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2115975	42849819	38345391	388	18313										
PLEKHM1	9842	broad.mit.edu	37	chr17	43522898	43522898	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aggtaatcccccaggagcttCagctgctcccgtctcctccc	8	18	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:43522898C>G	uc002ija.2	-	9	2945	c.2775G>C	c.(2773-2775)CTG>CTC	p.L925L	PLEKHM1_uc010wjm.1_Silent_p.L897L|PLEKHM1_uc002ijb.2_Silent_p.L400L|PLEKHM1_uc010wjn.1_Silent_p.L874L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	925					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CCAGGAGCTTCAGCTGCTCCC	0.592													0	0	0	0.006122	0	17	57										G	43522898	C	G	43522898	2	3	62	1	0	0	0	0	0	0	0	1	12080	813	29	1		1	PLEKHM1	17	43522898	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	673079	43522898	37672312	389	18314										
MYCBPAP	84073	broad.mit.edu	37	chr17	48604701	48604701	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaggatgcgttgatgaggctCaacaaagcagccctggagct	14	9	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:48604701C>T	uc010wmr.1	+	15	2514	c.2352C>T	c.(2350-2352)CTC>CTT	p.L784L	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	747					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGATGAGGCTCAACAAAGCAG	0.592													0	0	0	0.010504	0	20	119										T	48604701	C	T	48604701	2	4	62	1	0	0	0	0	0	0	0	1	10019	813	29	1		1	MYCBPAP	17	48604701	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5081803	48604701	32590509	390	18315										
CACNA1G	8913	broad.mit.edu	37	chr17	48655779	48655779	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcaacggagcctgggcccaGatgcagagcccagctctgtg	15	13	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:48655779G>C	uc002irk.1	+	9	2527	c.2155G>C	c.(2155-2157)GAT>CAT	p.D719H	CACNA1G_uc002iri.1_Missense_Mutation_p.D719H|CACNA1G_uc002irj.1_Missense_Mutation_p.D719H|CACNA1G_uc002irl.1_Missense_Mutation_p.D719H|CACNA1G_uc002irm.1_Missense_Mutation_p.D719H|CACNA1G_uc002irn.1_Missense_Mutation_p.D719H|CACNA1G_uc002iro.1_Missense_Mutation_p.D719H|CACNA1G_uc002irp.1_Missense_Mutation_p.D719H|CACNA1G_uc002irq.1_Missense_Mutation_p.D719H|CACNA1G_uc002irr.1_Missense_Mutation_p.D719H|CACNA1G_uc002irs.1_Missense_Mutation_p.D719H|CACNA1G_uc002irt.1_Missense_Mutation_p.D719H|CACNA1G_uc002irv.1_Missense_Mutation_p.D719H|CACNA1G_uc002irw.1_Missense_Mutation_p.D719H|CACNA1G_uc002iru.1_Missense_Mutation_p.D719H|CACNA1G_uc002irx.1_Missense_Mutation_p.D632H|CACNA1G_uc002iry.1_Missense_Mutation_p.D632H|CACNA1G_uc002irz.1_Missense_Mutation_p.D632H|CACNA1G_uc002isa.1_Missense_Mutation_p.D632H|CACNA1G_uc002isb.1_Missense_Mutation_p.D632H|CACNA1G_uc002isc.1_Missense_Mutation_p.D632H|CACNA1G_uc002isd.1_Missense_Mutation_p.D632H|CACNA1G_uc002ise.1_Missense_Mutation_p.D632H|CACNA1G_uc002isf.1_Missense_Mutation_p.D632H|CACNA1G_uc002isg.1_Missense_Mutation_p.D632H|CACNA1G_uc002ish.1_Missense_Mutation_p.D632H|CACNA1G_uc002isi.1_Missense_Mutation_p.D632H	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	719	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGGGCCCAGATGCAGAGCC	0.602													0	0	0	0.004007	0	17	61										C	48655779	G	C	48655779	3	2	62	1	0	0	0	0	1	0	0	0	2544	942	33	1	2189	1	CACNA1G	17	48655779	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	51078	48655779	32539431	391	18316										
HEATR6	63897	broad.mit.edu	37	chr17	58123500	58123500	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tagggcctggatagactcctCaatgatttctgcaaatgtgg	11	8	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:58123500C>G	uc002iyk.1	-	19	2877	c.2860G>C	c.(2860-2862)GAG>CAG	p.E954Q	HEATR6_uc010ddk.1_Missense_Mutation_p.E493Q|HEATR6_uc010wos.1_Missense_Mutation_p.E674Q	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	954							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ATAGACTCCTCAATGATTTCT	0.393													0	0	0	0.008361	0	25	62										G	58123500	C	G	58123500	3	3	62	1	0	0	0	0	1	0	0	0	7033	835	29	1	693	1	HEATR6	17	58123500	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	9467721	58123500	23071710	392	18317										
HEATR6	63897	broad.mit.edu	37	chr17	58156241	58156241	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtgcctcccgcggctgcacgGaaggccacgaaccgacaact	12	16	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:58156241G>A	uc002iyk.1	-	1	52	c.35C>T	c.(34-36)TCC>TTC	p.S12F		NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	12							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CGGCTGCACGGAAGGCCACGA	0.652													0	0	0	0.000602	0	4	26										A	58156241	G	A	58156241	3	1	62	1	0	0	0	0	1	0	0	0	7033	1174	41	1	3590	1	HEATR6	17	58156241	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	32741	58156241	23038969	393	18318										
GH1	2688	broad.mit.edu	37	chr17	61994708	61994708	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tccacagagcggcactgcacGatgcgcaggaatgtctcgac	12	13	1	1	rs148474991		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:61994708G>A	uc002jdj.2	-	5	677	c.615C>T	c.(613-615)ATC>ATT	p.I205I	GH1_uc002jdi.2_Silent_p.I190I|GH1_uc002jdk.2_Silent_p.I165I|GH1_uc002jdl.2_Silent_p.I110I|GH1_uc002jdm.2_3'UTR|GH1_uc002jdn.2_Missense_Mutation_p.S159L	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	205			I -> M (in short stature; idiopathic autosomal).		glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GGCACTGCACGATGCGCAGGA	0.592													0	0	0	0.008361	0	25	61										A	61994708	G	A	61994708	2	1	62	1	0	0	0	0	0	0	0	1	6367	1048	37	1		1	GH1	17	61994708	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	3838467	61994708	19200502	394	18319										
LRRC37A3	374819	broad.mit.edu	37	chr17	62854903	62854903	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attattgtccttacctcaatGaggcagagaagtataatcaa	7	7	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:62854903G>C	uc002jey.2	-	12	5334	c.4803C>G	c.(4801-4803)CTC>CTG	p.L1601L	LRRC37A3_uc010wqg.1_Silent_p.L719L|LRRC37A3_uc002jex.1_Silent_p.L578L|LRRC37A3_uc010wqf.1_Silent_p.L639L	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1601	Helical; (Potential).					integral to membrane					0						TTACCTCAATGAGGCAGAGAA	0.383													0	0	0	0.007413	0	20	57										C	62854903	G	C	62854903	2	2	62	1	0	0	0	0	0	0	0	1	8993	1277	45	1		1	LRRC37A3	17	62854903	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	860195	62854903	18340307	395	18320										
ABCA6	23460	broad.mit.edu	37	chr17	67132242	67132242	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggaaagtcacctgagaaatCttctttccaaagtggactgt	9	8	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:67132242C>G	uc002jhw.1	-	4	626	c.451G>C	c.(451-453)GAT>CAT	p.D151H	ABCA6_uc002jhy.2_Missense_Mutation_p.D149H	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	151					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					CCTGAGAAATCTTCTTTCCAA	0.323													0	0	0	0.001168	0	5	31										G	67132242	C	G	67132242	3	3	62	1	0	0	0	0	1	0	0	0	36	913	32	1	4546	1	ABCA6	17	67132242	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4277339	67132242	14062968	396	18321										
CD300LF	146722	broad.mit.edu	37	chr17	72699199	72699199	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtccaagtggtggccggtcaGagttggggagctgctagttt	17	7	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:72699199G>C	uc002jlg.2	-	3	524	c.421C>G	c.(421-423)CTG>GTG	p.L141V	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Missense_Mutation_p.L144V|CD300LF_uc010dfw.2_RNA|CD300LF_uc002jlh.2_Missense_Mutation_p.L141V|CD300LF_uc002jli.2_Missense_Mutation_p.L144V|CD300LF_uc010wra.1_Missense_Mutation_p.L156V|CD300LF_uc002jlj.1_Missense_Mutation_p.L159V	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	141	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1						TGGCCGGTCAGAGTTGGGGAG	0.547													0	0	0	0.001855	0	11	104										C	72699199	G	C	72699199	3	2	62	1	0	0	0	0	1	0	0	0	3001	933	33	1	471	1	CD300LF	17	72699199	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	5566957	72699199	8496011	397	18322										
CDK3	1018	broad.mit.edu	37	chr17	73998125	73998125	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgctggacgtggtgcacaacGagaggaagctctatctggtg	15	8	2	1	rs140567861		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:73998125G>C	uc010dgt.2	+	4	293	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	CDK3_uc002jqg.3_Missense_Mutation_p.E101Q	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	73	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						GGTGCACAACGAGAGGAAGCT	0.572													0	0	0	0.006122	0	14	68										C	73998125	G	C	73998125	3	2	62	1	0	0	0	0	1	0	0	0	3140	1059	37	1	227	1	CDK3	17	73998125	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1298926	73998125	7197085	398	18323										
C17orf70	80233	broad.mit.edu	37	chr17	79517599	79517599	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccaccaggcagtcacagtgCacatcctcgtcaggcagaaa	10	14	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:79517599C>T	uc002kaq.2	-	3	976	c.921G>A	c.(919-921)GTG>GTA	p.V307V	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Silent_p.V156V	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	307					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGTCACAGTGCACATCCTCGT	0.607													0	0	0	0.004007	0	12	74										T	79517599	C	T	79517599	2	4	62	1	0	0	0	0	0	0	0	1	1877	697	25	2		2	C17orf70	17	79517599	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5519474	79517599	1677611	399	18324										
CD7	924	broad.mit.edu	37	chr17	80274738	80274738	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtcctcgtagtaaatgatgtCttggggctgtggcccgagct	14	9	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:80274738C>G	uc002kel.1	-	2	311	c.202G>C	c.(202-204)GAC>CAC	p.D68H	CD7_uc010din.2_Missense_Mutation_p.D68H|CD7_uc002kem.2_Missense_Mutation_p.R49T|CD7_uc010wvk.1_Missense_Mutation_p.D68H	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	68	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			TAAATGATGTCTTGGGGCTGT	0.632													0	0	0	0.00632	0	24	55										G	80274738	C	G	80274738	3	3	62	1	0	0	0	0	1	0	0	0	3032	913	32	1	532	1	CD7	17	80274738	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	757139	80274738	920472	400	18325										
SLC14A2	8170	broad.mit.edu	37	chr18	43206949	43206949	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	accttgccctccagttcataGactgggtcctgagagggacc	11	13	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43206949G>C	uc010dnj.2	+	5	679	c.358G>C	c.(358-360)GAC>CAC	p.D120H	SLC14A2_uc002lbb.2_Missense_Mutation_p.D120H|SLC14A2_uc002lbe.2_Missense_Mutation_p.D120H	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	120						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CCAGTTCATAGACTGGGTCCT	0.557													0	0	0	0.012319	0	18	78										C	43206949	G	C	43206949	3	2	62	1	0	0	0	0	1	0	0	0	14397	942	33	1	368	1	SLC14A2	18	43206949	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		43206949	34870299	401	18326										
SLC14A2	8170	broad.mit.edu	37	chr18	43216988	43216988	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtgccttgaattccatcttCagcaagtgggacctcccggt	10	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43216988C>T	uc010dnj.2	+	7	1005	c.684C>T	c.(682-684)TTC>TTT	p.F228F	SLC14A2_uc002lbb.2_Silent_p.F228F|SLC14A2_uc002lbe.2_Silent_p.F228F	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	228						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						ATTCCATCTTCAGCAAGTGGG	0.512													0	0	0	0.01441	0	107	236										T	43216988	C	T	43216988	2	4	62	1	0	0	0	0	0	0	0	1	14397	825	29	1		1	SLC14A2	18	43216988	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10039	43216988	34860260	402	18327										
C18orf25	147339	broad.mit.edu	37	chr18	43842948	43842948	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttcttcatggaagcatggctCgggcacgcagtatgttagca	12	9	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43842948C>T	uc002lbw.2	+	6	1461	c.1082C>T	c.(1081-1083)TCG>TTG	p.S361L	C18orf25_uc002lbx.2_Missense_Mutation_p.S300L	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	360										central_nervous_system(2)	2						AAGCATGGCTCGGGCACGCAG	0.493													0	0	0	0.005443	0	19	113										T	43842948	C	T	43842948	3	4	62	1	0	0	0	0	1	0	0	0	1899	893	31	1	1093	1	C18orf25	18	43842948	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	625960	43842948	34234300	403	18328										
ATP8B1	5205	broad.mit.edu	37	chr18	55351301	55351301	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caccatgactgtgtggcaaaCtgcgagcaagaagaagaact	11	9	0	4			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:55351301C>G	uc002lgw.2	-	14	1597	c.1597G>C	c.(1597-1599)GTT>CTT	p.V533L	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	533	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GTGTGGCAAACTGCGAGCAAG	0.448									Byler_disease				0	0	0	0.006122	0	13	69										G	55351301	C	G	55351301	3	3	62	1	0	0	0	0	1	0	0	0	1194	565	20	4	2214	4	ATP8B1	18	55351301	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	11508353	55351301	22725947	404	18329										
ATP8B1	5205	broad.mit.edu	37	chr18	55351394	55351394	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ataaaatgcaagcttcccatCagcatatgtattccagctaa	5	10	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:55351394C>T	uc002lgw.2	-	14	1504	c.1504G>A	c.(1504-1506)GAT>AAT	p.D502N	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	502	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				AGCTTCCCATCAGCATATGTA	0.348									Byler_disease				0	0	0	0.008291	0	9	33										T	55351394	C	T	55351394	3	4	62	1	0	0	0	0	1	0	0	0	1194	826	29	1	2307	1	ATP8B1	18	55351394	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	93	55351394	22725854	405	18330										
MC4R	4160	broad.mit.edu	37	chr18	58038833	58038833	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagacaacaaagacgccaatCaggatggtcaaggtaatcgc	10	10	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:58038833C>T	uc002lie.1	-	1	1169	c.750G>A	c.(748-750)CTG>CTA	p.L250L		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	250	Helical; Name=6; (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				AGACGCCAATCAGGATGGTCA	0.498													0	0	0	0.005443	0	23	29										T	58038833	C	T	58038833	2	4	62	1	0	0	0	0	0	0	0	1	9366	813	29	1		1	MC4R	18	58038833	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2687439	58038833	20038415	406	18331										
ZNF555	148254	broad.mit.edu	37	chr19	2852858	2852858	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaggaatgtgggaaagctttCagttattcctcaacgtttcg	10	7	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:2852858C>A	uc002lwo.2	+	4	884	c.795C>A	c.(793-795)TTC>TTA	p.F265L	ZNF555_uc002lwn.3_Missense_Mutation_p.F264L	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	265	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAAGCTTTCAGTTATTCCT	0.408													1	0	9.70103e-10	0.008291	1.03774e-09	9	50										A	2852858	C	A	2852858	3	1	62	1	0	0	0	0	1	0	0	0	17983	825	29	3	809	3	ZNF555	19	2852858	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		2852858	56276125	407	18332										
PLIN3	10226	broad.mit.edu	37	chr19	4859922	4859922	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cactcccttctctgctgcgtCgcagacagtcttgatgtgcg	10	14	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:4859922C>T	uc002mbj.2	-	3	358	c.181G>A	c.(181-183)GAC>AAC	p.D61N	PLIN3_uc002mbk.2_Missense_Mutation_p.D61N|PLIN3_uc002mbl.3_Missense_Mutation_p.D61N	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	61					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTGCTGCGTCGCAGACAGTC	0.637													0	0	0	0.000602	0	3	25										T	4859922	C	T	4859922	3	4	62	1	0	0	0	0	1	0	0	0	12091	884	31	1	1147	1	PLIN3	19	4859922	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2007064	4859922	54269061	408	18333										
GTF2F1	2962	broad.mit.edu	37	chr19	6392882	6392882	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acttacttaggaactcgaacGacgtattcagtgacattctg	8	9	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:6392882G>A	uc002meq.2	-	2	330	c.45C>T	c.(43-45)GTC>GTT	p.V15V	GTF2F1_uc010xjc.1_5'Flank	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	15					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GAACTCGAACGACGTATTCAG	0.587											OREG0025199	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	44	186										A	6392882	G	A	6392882	2	1	62	1	0	0	0	0	0	0	0	1	6858	1045	37	1		1	GTF2F1	19	6392882	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1532960	6392882	52736101	409	18334										
ANGPTL4	51129	broad.mit.edu	37	chr19	8436324	8436324	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcgccaccaccgtcccaccCagcggcctctccgtaccctt	8	22	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:8436324C>G	uc002mjq.1	+	6	1152	c.957C>G	c.(955-957)CCC>CCG	p.P319P	ANGPTL4_uc002mjr.1_Silent_p.P281P|ANGPTL4_uc010xkc.1_Silent_p.P152P	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	319	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						CCGTCCCACCCAGCGGCCTCT	0.667													0	0	0	0.001984	0	5	25										G	8436324	C	G	8436324	2	3	62	1	0	0	0	0	0	0	0	1	616	581	21	4		4	ANGPTL4	19	8436324	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2043442	8436324	50692659	410	18335										
MUC16	94025	broad.mit.edu	37	chr19	9062870	9062870	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atcatttctgctgattctgtCattatgctggaggtagggag	12	6	4	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:9062870C>G	uc002mkp.2	-	3	24780	c.24576G>C	c.(24574-24576)ATG>ATC	p.M8192I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8194	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGATTCTGTCATTATGCTGG	0.483													0	0	0	0.013537	0	13	31										G	9062870	C	G	9062870	3	3	62	1	0	0	0	0	1	0	0	0	9973	826	29	1	19275	1	MUC16	19	9062870	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	626546	9062870	50066113	411	18336										
DNMT1	1786	broad.mit.edu	37	chr19	10286275	10286275	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggctctttcagactcttcctGaggtttccgtttggcagggc	12	11	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:10286275G>C	uc002mng.2	-	6	721	c.541C>G	c.(541-543)CAG>GAG	p.Q181E	DNMT1_uc010xlc.1_Missense_Mutation_p.Q197E|DNMT1_uc002mnh.2_Missense_Mutation_p.Q76E|DNMT1_uc010xld.1_Missense_Mutation_p.Q181E	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	181	Nuclear localization signal (Potential).|Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GACTCTTCCTGAGGTTTCCGT	0.512													0	0	0	0.007291	0	23	53										C	10286275	G	C	10286275	3	2	62	1	0	0	0	0	1	0	0	0	4675	1299	45	1	4449	1	DNMT1	19	10286275	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1223405	10286275	48842708	412	18337										
DNMT1	1786	broad.mit.edu	37	chr19	10287981	10287981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tactgacccctttgcaaaatGagatgtgatggtggtttgcc	11	8	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:10287981G>C	uc002mng.2	-	5	688	c.508C>G	c.(508-510)CAT>GAT	p.H170D	DNMT1_uc010xlc.1_Missense_Mutation_p.H186D|DNMT1_uc002mnh.2_Missense_Mutation_p.H65D|DNMT1_uc010xld.1_Missense_Mutation_p.H170D|DNMT1_uc010dxb.1_RNA	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	170	Interaction with PCNA.|Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).			H->V: Abolishes interaction with PCNA.	chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TTTGCAAAATGAGATGTGATG	0.438													0	0	0	0.006214	0	7	36										C	10287981	G	C	10287981	3	2	62	1	0	0	0	0	1	0	0	0	4675	1290	45	1	4486	1	DNMT1	19	10287981	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1706	10287981	48841002	413	18338										
NWD1	284434	broad.mit.edu	37	chr19	16860125	16860125	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgatgcccagaaccttctCagcagcctcaaaagtcacat	7	14	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:16860125C>G	uc002neu.3	+	6	1094	c.672C>G	c.(670-672)CTC>CTG	p.L224L	NWD1_uc002net.3_Silent_p.L89L|NWD1_uc002nev.3_Silent_p.L18L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	224							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						AGAACCTTCTCAGCAGCCTCA	0.587													0	0	0	0.013537	0	12	64										G	16860125	C	G	16860125	2	3	62	1	0	0	0	0	0	0	0	1	10781	813	29	1		1	NWD1	19	16860125	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6572144	16860125	42268858	414	18339										
CILP2	148113	broad.mit.edu	37	chr19	19654990	19654990	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttttgatcctcgaggtgccGgcgtgtaccacgaggtcaag	13	11	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:19654990G>A	uc002nmv.3	+	8	1721	c.1636G>A	c.(1636-1638)GGC>AGC	p.G546S	CILP2_uc002nmw.3_Missense_Mutation_p.G552S	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	546						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						TCGAGGTGCCGGCGTGTACCA	0.617													0	0	0	0.004672	0	3	71										A	19654990	G	A	19654990	3	1	62	1	0	0	0	0	1	0	0	0	3430	1116	39	2	1666	2	CILP2	19	19654990	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	2794865	19654990	39473993	415	18340										
HAUS5	23354	broad.mit.edu	37	chr19	36108218	36108218	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cgaacagcctgcaccctccgGgcccagttcctgcagaacct	9	18	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:36108218G>T	uc002oam.1	+	8	636	c.585G>T	c.(583-585)CGG>CGT	p.R195R		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	195					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						GCACCCTCCGGGCCCAGTTCC	0.632													1	0	2.64894e-19	0.01441	3.01628e-19	35	52										T	36108218	G	T	36108218	2	4	62	1	0	0	0	0	0	0	0	1	6969	1219	43	4		4	HAUS5	19	36108218	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	16453228	36108218	23020765	416	18341										
HCST	10870	broad.mit.edu	37	chr19	36394703	36394703	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccggatgtgggtccctctctCtgccgctcctggcaggcctc	12	17	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:36394703C>G	uc002ocl.1	+	3	253	c.139C>G	c.(139-141)CTG>GTG	p.L47V	HCST_uc002ock.1_Missense_Mutation_p.L47V	NM_014266	NP_055081	Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer isoform 1	47	Extracellular (Potential).				regulation of immune response	integral to membrane|plasma membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTCCCTCTCTCTGCCGCTCCT	0.682													0	0	0	0.00308	0	5	32										G	36394703	C	G	36394703	3	3	62	1	0	0	0	0	1	0	0	0	7003	912	32	1	149	1	HCST	19	36394703	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	286485	36394703	22734280	417	18342										
ZNF567	163081	broad.mit.edu	37	chr19	37211086	37211086	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcactgtgggaaggcctttaGaatgaagtcatacctcattg	10	8	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:37211086G>C	uc010xtl.1	+	6	1682	c.1460G>C	c.(1459-1461)AGA>ACA	p.R487T	ZNF567_uc002oeo.1_Missense_Mutation_p.R487T|ZNF567_uc010xtk.1_Missense_Mutation_p.R487T|ZNF567_uc002oep.3_Missense_Mutation_p.R456T|ZNF567_uc002oeq.1_Missense_Mutation_p.R456T	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	487	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAGGCCTTTAGAATGAAGTCA	0.418													0	0	0	0.005443	0	22	69										C	37211086	G	C	37211086	3	2	62	1	0	0	0	0	1	0	0	0	17995	942	33	1	1377	1	ZNF567	19	37211086	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	816383	37211086	21917897	418	18343										
SUPT5H	6829	broad.mit.edu	37	chr19	39962359	39962359	+	Frame_Shift_Del	DEL	G	G	-													0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cccgccacctggtgctggctGggggctcaaaggtgaggtgg							TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:39962359delG	uc002olo.3	+	20	2118	c.1939delG	c.(1939-1941)GGGfs	p.G647fs	SUPT5H_uc002olp.3_Frame_Shift_Del_p.G647fs|SUPT5H_uc002olq.3_Frame_Shift_Del_p.G643fs|SUPT5H_uc002oln.3_Frame_Shift_Del_p.G647fs|SUPT5H_uc002olr.3_Frame_Shift_Del_p.G647fs|SUPT5H_uc002ols.1_Frame_Shift_Del_p.G270fs|SUPT5H_uc010egp.1_Frame_Shift_Del_p.G13fs	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	647					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGTGCTGGCTGGGGGCTCAAA	0.587																		15	40	---	---								-	39962359	G	-	39962359	7	5	62	1	0	1	0	1	0	0	0	0	15396	1348	47	0	2013	0	SUPT5H	19	39962359	Frame_Shift_Del	DEL	G	TCGA-DK-A3IT-01A-31D-A20D-08	2751273	39962359	19166624	419	18344										
SYMPK	8189	broad.mit.edu	37	chr19	46345718	46345718	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cttacgcacactgctcacctGcgatttggccagcgtcgggg	12	14	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:46345718G>A	uc002pdn.2	-	9	1122	c.877C>T	c.(877-879)CAG>TAG	p.Q293*	SYMPK_uc002pdo.1_Nonsense_Mutation_p.Q293*|SYMPK_uc002pdp.1_Nonsense_Mutation_p.Q293*|SYMPK_uc002pdq.1_Nonsense_Mutation_p.Q293*	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	293					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CTGCTCACCTGCGATTTGGCC	0.562													0	0	0	0.010504	0	15	80										A	46345718	G	A	46345718	4	1	62	1	0	0	0	0	0	1	0	0	15436	1328	46	2	3023	2	SYMPK	19	46345718	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	6383359	46345718	12783265	420	18345										
IRF2BP1	26145	broad.mit.edu	37	chr19	46387865	46387865	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggtcatcttcccagccgcctCgccctccggctcgggggatg	13	17	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:46387865C>T	uc002pds.1	-	1	1512	c.1168G>A	c.(1168-1170)GAG>AAG	p.E390K		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CCAGCCGCCTCGCCCTCCGGC	0.751													0	0	0	0.006214	0	9	20										T	46387865	C	T	46387865	3	4	62	1	0	0	0	0	1	0	0	0	7829	893	31	1	590	1	IRF2BP1	19	46387865	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	42147	46387865	12741118	421	18346										
NR1H2	7376	broad.mit.edu	37	chr19	50881884	50881884	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gccgcagggcagcagcagctCagcctctgggcctggggctt	16	14	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:50881884C>A	uc010enw.2	+	7	857	c.581C>A	c.(580-582)TCA>TAA	p.S194*	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Nonsense_Mutation_p.S193*|NR1H2_uc002psa.3_Nonsense_Mutation_p.S96*	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	193	Poly-Ser.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGCAGCAGCTCAGCCTCTGGG	0.607													1	0	7.05477e-17	0.00499	7.86411e-17	16	17										A	50881884	C	A	50881884	4	1	62	1	0	0	0	0	0	1	0	0	10617	838	29	3	592	3	NR1H2	19	50881884	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4494019	50881884	8247099	422	18347										
ZNF547	284306	broad.mit.edu	37	chr19	57888951	57888951	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggtccacactcaatagacatCagagaactcacactggagaa	8	11	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:57888951C>G	uc002qol.2	+	4	800	c.607C>G	c.(607-609)CAG>GAG	p.Q203E	ZNF547_uc002qpm.3_Missense_Mutation_p.Q129E|ZNF547_uc010ygx.1_Missense_Mutation_p.Q203E	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	203	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAATAGACATCAGAGAACTCA	0.418													0	0	0	0.003271	0	28	39										G	57888951	C	G	57888951	3	3	62	1	0	0	0	0	1	0	0	0	17976	827	29	1	617	1	ZNF547	19	57888951	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7007067	57888951	1240032	423	18348										
ZNF549	256051	broad.mit.edu	37	chr19	58048854	58048854	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagtggagagaaacacatcaGaaaggaggagagcagtgcct	14	7	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:58048854G>A	uc002qpb.1	+	4	731	c.482G>A	c.(481-483)AGA>AAA	p.R161K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.R148K	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAACACATCAGAAAGGAGGAG	0.453													0	0	0	0.00278	0	22	50										A	58048854	G	A	58048854	3	1	62	1	0	0	0	0	1	0	0	0	17978	942	33	1	453	1	ZNF549	19	58048854	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	159903	58048854	1080129	424	18349										
ZNF587	84914	broad.mit.edu	37	chr19	58367529	58367529	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttcccaggaggagtggtgtCttcttagtgaggctcagagg	15	7	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:58367529C>T	uc002qql.2	+	2	229	c.91C>T	c.(91-93)CTT>TTT	p.L31F	ZNF587_uc002qqb.2_5'UTR|ZNF587_uc010yhh.1_5'UTR|ZNF587_uc002qqi.1_5'UTR|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Missense_Mutation_p.L30F	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		GGAGTGGTGTCTTCTTAGTGA	0.512													0	0	0	0.007291	0	17	67										T	58367529	C	T	58367529	3	4	62	1	0	0	0	0	1	0	0	0	18017	913	32	1	97	1	ZNF587	19	58367529	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	318675	58367529	761454	425	18350										
TRIB3	57761	broad.mit.edu	37	chr20	376874	376874	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctggagaacctggaggactCctgcgtgctgactgggccag	16	11	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:376874C>T	uc002wdm.2	+	4	1123	c.617C>T	c.(616-618)TCC>TTC	p.S206F	TRIB3_uc002wdn.2_Missense_Mutation_p.S233F	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	206	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CTGGAGGACTCCTGCGTGCTG	0.607													0	0	0	0.00245	0	12	57										T	376874	C	T	376874	3	4	62	1	0	0	0	0	1	0	0	0	16481	855	30	1	627	1	TRIB3	20	376874	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		376874	62648646	426	18351										
RIN2	54453	broad.mit.edu	37	chr20	19977329	19977329	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tctgctcttttcaggaggctAttacttgacaagcgcatatg	9	9	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:19977329A>G	uc002wro.1	+	10	2243	c.2207A>G	c.(2206-2208)TAT>TGT	p.Y736C	RIN2_uc010gcu.1_Missense_Mutation_p.Y303C|RIN2_uc010gcv.1_Missense_Mutation_p.Y530C	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	736	VPS9.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TCAGGAGGCTATTACTTGACA	0.498													0	0	0	0.004007	0	15	44										G	19977329	A	G	19977329	3	3	62	1	0	0	0	0	1	0	0	0	13372	449	16	5	2245	5	RIN2	20	19977329	Missense_Mutation	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	19600455	19977329	43048191	427	18352										
KIF3B	9371	broad.mit.edu	37	chr20	30897849	30897849	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtcctgcaaggtttcaatgGaaccatttttgcctatggac	9	9	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:30897849G>A	uc002wxq.2	+	2	436	c.269G>A	c.(268-270)GGA>GAA	p.G90E	KIF3B_uc010ztv.1_Missense_Mutation_p.G90E|KIF3B_uc010ztw.1_Missense_Mutation_p.G90E	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	90	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGTTTCAATGGAACCATTTTT	0.453													0	0	0	0.009718	0	35	78										A	30897849	G	A	30897849	3	1	62	1	0	0	0	0	1	0	0	0	8301	1174	41	1	271	1	KIF3B	20	30897849	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10920520	30897849	32127671	428	18353										
C20orf70	140683	broad.mit.edu	37	chr20	31767433	31767433	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgtccactgatccgcatcttCatccactccctggatgtgaa	7	14	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:31767433C>A	uc002wyo.1	+	7	740	c.669C>A	c.(667-669)TTC>TTA	p.F223L		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	223						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						TCCGCATCTTCATCCACTCCC	0.527													1	0	5.02048e-33	0.01441	5.86561e-33	60	147										A	31767433	C	A	31767433	3	1	62	1	0	0	0	0	1	0	0	0	2116	825	29	3	691	3	C20orf70	20	31767433	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	869584	31767433	31258087	429	18354										
CBFA2T2	9139	broad.mit.edu	37	chr20	32217653	32217653	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tacaatgaaaacacagagctGaggaaaacggggaccgagtt	12	7	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:32217653G>A	uc002wzg.1	+	9	1725	c.1188G>A	c.(1186-1188)CTG>CTA	p.L396L	CBFA2T2_uc010zug.1_Silent_p.L170L|CBFA2T2_uc002wze.1_Silent_p.L387L|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.L367L|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	396						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						ACACAGAGCTGAGGAAAACGG	0.507													0	0	0	0.001168	0	5	34										A	32217653	G	A	32217653	2	1	62	1	0	0	0	0	0	0	0	1	2697	1277	45	1		1	CBFA2T2	20	32217653	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	450220	32217653	30807867	430	18355										
SLC2A10	81031	broad.mit.edu	37	chr20	45354826	45354826	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tcccagatctggagacccctCagcccctcctcggctggccc	9	20	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:45354826C>T	uc002xsl.2	+	2	1248	c.1151C>T	c.(1150-1152)TCA>TTA	p.S384L		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	384	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGAGACCCCTCAGCCCCTCCT	0.632													0	0	0	0.00245	0	12	57										T	45354826	C	T	45354826	3	4	62	1	0	0	0	0	1	0	0	0	14539	838	29	1	1157	1	SLC2A10	20	45354826	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	13137173	45354826	17670694	431	18356										
TAF4	6874	broad.mit.edu	37	chr20	60575694	60575694	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttagcgtgcccaccaattcaGagttcgtggctaatattctt	8	10	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:60575694G>A	uc002ybs.2	-	10	2570	c.2570C>T	c.(2569-2571)TCT>TTT	p.S857F		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	857					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CACCAATTCAGAGTTCGTGGC	0.443													0	0	0	0.010771	0	40	52										A	60575694	G	A	60575694	3	1	62	1	0	0	0	0	1	0	0	0	15523	942	33	1	711	1	TAF4	20	60575694	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	15220868	60575694	2449826	432	18357										
LAMA5	3911	broad.mit.edu	37	chr20	60900379	60900379	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtcctaacctcacctggcatGagtccccccggtagctggcg	11	16	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:60900379G>T	uc002ycq.2	-	41	5589	c.5522C>A	c.(5521-5523)TCA>TAA	p.S1841*		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1841	Laminin EGF-like 16; second part.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTGGCATGAGTCCCCCCG	0.677													1	0	0.000978159	0.010729	0.00100754	9	15										T	60900379	G	T	60900379	4	4	62	1	0	0	0	0	0	1	0	0	8609	1294	45	3	5725	3	LAMA5	20	60900379	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	324685	60900379	2125141	433	18358										
DIDO1	11083	broad.mit.edu	37	chr20	61541311	61541311	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	caaaagcctccctcgagcctCagaaatgcccacacaatcgc	6	17	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61541311C>T	uc002ydr.1	-	4	1165	c.901G>A	c.(901-903)GAG>AAG	p.E301K	DIDO1_uc002yds.1_Missense_Mutation_p.E301K|DIDO1_uc002ydt.1_Missense_Mutation_p.E301K|DIDO1_uc002ydu.1_Missense_Mutation_p.E301K|DIDO1_uc002ydv.1_Missense_Mutation_p.E301K|DIDO1_uc002ydw.1_Missense_Mutation_p.E301K|DIDO1_uc002ydx.1_Missense_Mutation_p.E301K|DIDO1_uc011aao.1_Missense_Mutation_p.E301K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	301	PHD-type.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCTCGAGCCTCAGAAATGCCC	0.453													0	0	0	0.010818	0	25	63										T	61541311	C	T	61541311	3	4	62	1	0	0	0	0	1	0	0	0	4522	835	29	1	6003	1	DIDO1	20	61541311	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	640932	61541311	1484209	434	18359										
ARFGAP1	55738	broad.mit.edu	37	chr20	61907473	61907473	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	agtgtggcgcgttcaatcctCagtgggtcagtgtgacctac	13	10	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61907473C>G	uc002yem.2	+	3	203	c.91C>G	c.(91-93)CAG>GAG	p.Q31E	ARFGAP1_uc011aas.1_Intron|ARFGAP1_uc011aat.1_5'UTR|ARFGAP1_uc002yel.2_Missense_Mutation_p.Q31E|ARFGAP1_uc002yen.2_Missense_Mutation_p.Q31E	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	31	C4-type.|Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GTTCAATCCTCAGTGGGTCAG	0.617													0	0	0	0.01441	0	85	154										G	61907473	C	G	61907473	3	3	62	1	0	0	0	0	1	0	0	0	849	827	29	1	97	1	ARFGAP1	20	61907473	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	366162	61907473	1118047	435	18360										
COL20A1	57642	broad.mit.edu	37	chr20	61936830	61936830	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaggccacagtggggggcctGagcccctccaagggctacac	14	14	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61936830G>C	uc011aau.1	+	4	355	c.255G>C	c.(253-255)CTG>CTC	p.L85L	COL20A1_uc011aav.1_5'Flank	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	85	Fibronectin type-III 1.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGGGGGGCCTGAGCCCCTCCA	0.612													0	0	0	0.010729	0	8	11										C	61936830	G	C	61936830	2	2	62	1	0	0	0	0	0	0	0	1	3679	1277	45	1		1	COL20A1	20	61936830	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	29357	61936830	1088690	436	18361										
N6AMT1	29104	broad.mit.edu	37	chr21	30255367	30255367	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagatactacaccagaccctGaccctacttccaggcatatt	5	15	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:30255367G>A	uc002ymo.1	-	2	187	c.161C>T	c.(160-162)TCA>TTA	p.S54L	N6AMT1_uc002ymp.1_Missense_Mutation_p.S54L|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	54	S-adenosyl-L-methionine binding (By similarity).				positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						ACCAGACCCTGACCCTACTTC	0.368													0	0	0	0.004007	0	11	52										A	30255367	G	A	30255367	3	1	62	1	0	0	0	0	1	0	0	0	10114	1294	45	1	503	1	N6AMT1	21	30255367	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		30255367	17874528	437	18362										
SOD1	6647	broad.mit.edu	37	chr21	33036175	33036175	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcctgcatggattccatgttCatgagtttggagataataca	10	7	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:33036175C>G	uc002ypa.2	+	2	293	c.145C>G	c.(145-147)CAT>GAT	p.H49D	SOD1_uc002ypb.2_Missense_Mutation_p.H30D|SOD1_uc002ypc.2_RNA	NM_000454	NP_000445	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	49		Copper; catalytic.	H -> Q (in ALS1).|H -> R (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding				0						ATTCCATGTTCATGAGTTTGG	0.448													0	0	0	0.01441	0	37	140										G	33036175	C	G	33036175	3	3	62	1	0	0	0	0	1	0	0	0	14920	826	29	1	151	1	SOD1	21	33036175	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2780808	33036175	15093720	438	18363										
SOD1	6647	broad.mit.edu	37	chr21	33039670	33039670	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctctcaggagaccattgcatCattggccgcacactggtggt	11	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:33039670C>T	uc002ypa.2	+	4	487	c.339C>T	c.(337-339)ATC>ATT	p.I113I	SOD1_uc002ypb.2_Silent_p.I94I|SOD1_uc002ypc.2_RNA	NM_000454	NP_000445	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	113			I -> M (in ALS1).|I -> T (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding				0						ACCATTGCATCATTGGCCGCA	0.428													0	0	0	0.007291	0	21	165										T	33039670	C	T	33039670	2	4	62	1	0	0	0	0	0	0	0	1	14920	816	29	1		1	SOD1	21	33039670	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	3495	33039670	15090225	439	18364										
SON	6651	broad.mit.edu	37	chr21	34927106	34927106	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gatcatctaagtccaagtctCatcgctctcagacacgttca	6	13	5	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:34927106C>T	uc002yse.1	+	3	5618	c.5569C>T	c.(5569-5571)CAT>TAT	p.H1857Y	SON_uc002ysb.1_Missense_Mutation_p.H1857Y|SON_uc002ysc.2_Missense_Mutation_p.H1857Y|SON_uc002ysd.2_Missense_Mutation_p.H848Y|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.H848Y	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1857					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GTCCAAGTCTCATCGCTCTCA	0.448													0	0	0	0.005443	0	22	77										T	34927106	C	T	34927106	3	4	62	1	0	0	0	0	1	0	0	0	14926	826	29	1	5579	1	SON	21	34927106	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1887436	34927106	13202789	440	18365										
DOPEY2	9980	broad.mit.edu	37	chr21	37603182	37603182	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cagatgctgtcagacttgttCacagcacgagggtctccatt	10	11	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:37603182C>G	uc002yvg.2	+	14	2179	c.2100C>G	c.(2098-2100)TTC>TTG	p.F700L	DOPEY2_uc011aeb.1_Missense_Mutation_p.F700L	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	700					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CAGACTTGTTCACAGCACGAG	0.542													0	0	0	0.004482	0	8	81										G	37603182	C	G	37603182	3	3	62	1	0	0	0	0	1	0	0	0	4708	825	29	1	2150	1	DOPEY2	21	37603182	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2676076	37603182	10526713	441	18366										
HLCS	3141	broad.mit.edu	37	chr21	38126702	38126702	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tggtccctctgcgctgcccaGatggacttgctgaccactga	11	14	1	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:38126702G>C	uc010gnb.2	-	11	3227	c.2026C>G	c.(2026-2028)CTG>GTG	p.L676V	HLCS_uc002yvs.2_Missense_Mutation_p.L676V	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	676					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GCGCTGCCCAGATGGACTTGC	0.557													0	0	0	0.006122	0	12	41										C	38126702	G	C	38126702	3	2	62	1	0	0	0	0	1	0	0	0	7213	933	33	1	158	1	HLCS	21	38126702	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	523520	38126702	10003193	442	18367										
TTC3	7267	broad.mit.edu	37	chr21	38463619	38463619	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttggcaatggaagaagctctGaattggataaaatatgcagg	12	4	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:38463619G>C	uc002yvz.2	+	7	612	c.507G>C	c.(505-507)CTG>CTC	p.L169L	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Silent_p.L169L|TTC3_uc002ywb.2_Silent_p.L169L|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Silent_p.L169L	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	169					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AAGAAGCTCTGAATTGGATAA	0.308													0	0	0	0.00245	0	11	68										C	38463619	G	C	38463619	2	2	62	1	0	0	0	0	0	0	0	1	16694	1277	45	1		1	TTC3	21	38463619	Silent	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	336917	38463619	9666276	443	18368										
BRWD1	54014	broad.mit.edu	37	chr21	40627734	40627734	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	atttggaggggactgaatgtCtaagctcagccttctaaaac	10	8	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:40627734C>G	uc002yxk.1	-	19	2231	c.2092G>C	c.(2092-2094)GAC>CAC	p.D698H	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.D698H|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Missense_Mutation_p.D151H|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_Intron|BRWD1_uc010goi.1_Missense_Mutation_p.D418H	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	698					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GACTGAATGTCTAAGCTCAGC	0.418													0	0	0	0.003163	0	14	65										G	40627734	C	G	40627734	3	3	62	1	0	0	0	0	1	0	0	0	1525	913	32	1	5205	1	BRWD1	21	40627734	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2164115	40627734	7502161	444	18369										
C21orf29	54084	broad.mit.edu	37	chr21	45948429	45948429	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gcgtcttccacctcggtacaCggtggctggggtcccagcgt	14	14	1	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:45948429C>T	uc002zfe.1	-	6	894	c.828G>A	c.(826-828)CCG>CCA	p.P276P	C21orf29_uc010gpv.1_Silent_p.P208P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	276					cell adhesion	extracellular region	structural molecule activity				0						CCTCGGTACACGGTGGCTGGG	0.577													0	0	0	0.005443	0	27	25										T	45948429	C	T	45948429	2	4	62	1	0	0	0	0	0	0	0	1	2124	523	19	2		2	C21orf29	21	45948429	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5320695	45948429	2181466	445	18370										
KRTAP12-4	386684	broad.mit.edu	37	chr21	46074247	46074247	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctatagaccagggtggggcaGaagggctggcagcacccaga	16	10	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:46074247G>C	uc002zfs.1	-	1	330	c.285C>G	c.(283-285)TTC>TTG	p.F95L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	95	15 X 5 AA approximate repeats.|14.					keratin filament				ovary(1)	1						GGGTGGGGCAGAAGGGCTGGC	0.632													0	0	0	0.001168	0	6	31										C	46074247	G	C	46074247	3	2	62	1	0	0	0	0	1	0	0	0	8521	933	33	1	57	1	KRTAP12-4	21	46074247	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	125818	46074247	2055648	446	18371										
GNB1L	54584	broad.mit.edu	37	chr22	19808787	19808787	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcgcccctgagcctgggctCcttcgcagaagtgcagcgca	14	15	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:19808787C>G	uc002zqe.1	-	2	486	c.92G>C	c.(91-93)GGA>GCA	p.G31A	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqf.1_Missense_Mutation_p.G31A	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	31	WD 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					AGCCTGGGCTCCTTCGCAGAA	0.687													0	0	0	0.008871	0	18	71										G	19808787	C	G	19808787	3	3	62	1	0	0	0	0	1	0	0	0	6516	855	30	1	915	1	GNB1L	22	19808787	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08		19808787	31495779	447	18372										
SMARCB1	6598	broad.mit.edu	37	chr22	24175882	24175882	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aagatccgcgaccaggacagGaacacgaggtacccctggcc	12	14	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:24175882G>T	uc002zyb.2	+	8	1317	c.1110G>T	c.(1108-1110)AGG>AGT	p.R370S	SMARCB1_uc002zya.2_Intron|SMARCB1_uc002zyc.2_Missense_Mutation_p.R361S|SMARCB1_uc002zyd.2_Missense_Mutation_p.R379S	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	370					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)|p.L266_*386del(1)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				ACCAGGACAGGAACACGAGGT	0.622			D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				1	0	1.15919e-05	0.008871	1.20464e-05	17	38										T	24175882	G	T	24175882	3	4	62	1	0	0	0	0	1	0	0	0	14774	1165	41	3	1140	3	SMARCB1	22	24175882	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4367095	24175882	27128684	448	18373										
HSCB	150274	broad.mit.edu	37	chr22	29138168	29138168	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gaaggagaccgctaagctgcGatgctgcgtcgcaggcggga	17	10	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:29138168G>T	uc003aea.2	+	1	126	c.85G>T	c.(85-87)GAT>TAT	p.D29Y	CHEK2_uc003adt.1_5'Flank|CHEK2_uc003adu.1_5'Flank|CHEK2_uc003adv.1_5'Flank|CHEK2_uc003adw.1_5'Flank|CHEK2_uc003adx.1_5'Flank|CHEK2_uc003ady.1_5'Flank|CHEK2_uc003adz.1_5'Flank	NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	29					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						GCTAAGCTGCGATGCTGCGTC	0.682													1	0	0.00909568	0.009096	0.00928683	3	12										T	29138168	G	T	29138168	3	4	62	1	0	0	0	0	1	0	0	0	7374	1058	37	3	87	3	HSCB	22	29138168	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	4962286	29138168	22166398	449	18374										
TBC1D10A	83874	broad.mit.edu	37	chr22	30722721	30722721	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ttgtcgatgcggcgctcggcGaagccgttggcctccgagtc	15	13	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:30722721G>T	uc011akt.1	-	1	174	c.150C>A	c.(148-150)TTC>TTA	p.F50L	TBC1D10A_uc010gvu.2_Missense_Mutation_p.F50L|TBC1D10A_uc003ahk.3_Missense_Mutation_p.F50L	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	50						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						GGCGCTCGGCGAAGCCGTTGG	0.711													1	0	2.41591e-17	0.004656	2.70861e-17	19	32										T	30722721	G	T	30722721	3	4	62	1	0	0	0	0	1	0	0	0	15595	1049	37	3	1412	3	TBC1D10A	22	30722721	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1584553	30722721	20581845	450	18375										
SEC14L3	266629	broad.mit.edu	37	chr22	30860840	30860840	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aattttcctgcgagtgtcctCactcaggaatggcttcatga	9	10	3	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:30860840C>T	uc003ahy.2	-	8	720	c.631G>A	c.(631-633)GAG>AAG	p.E211K	SEC14L3_uc003ahz.2_Missense_Mutation_p.E134K|SEC14L3_uc003aia.2_Missense_Mutation_p.E152K|SEC14L3_uc003aib.2_Missense_Mutation_p.E152K	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	211	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	CGAGTGTCCTCACTCAGGAAT	0.448													0	0	0	0.01441	0	60	121										T	30860840	C	T	30860840	3	4	62	1	0	0	0	0	1	0	0	0	13983	835	29	1	591	1	SEC14L3	22	30860840	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	138119	30860840	20443726	451	18376										
MAFF	23764	broad.mit.edu	37	chr22	38609853	38609853	+	Translation_Start_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgcagcccagagggcaccttCtgcaaacatgtctgtggatc	11	12	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:38609853C>A	uc011anp.1	+	2	331	c.-7C>A	c.(-9--5)TTCTG>TTATG		MAFF_uc003avc.2_Translation_Start_Site|MAFF_uc011anq.1_Intron|MAFF_uc011anr.1_Translation_Start_Site|MAFF_uc003avd.2_Missense_Mutation_p.F47L	NM_001161572	NP_001155044	Q9ULX9	MAFF_HUMAN	transcription factor MAFF isoform a						blood coagulation|parturition|transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.045)					AGGGCACCTTCTGCAAACATG	0.438													1	0	2.19962e-31	0.00874	2.56476e-31	33	69										A	38609853	C	A	38609853	1	1	62	1	0	0	0	0	0	0	0	0	9159	928	32	3		3	MAFF	22	38609853	Translation_Start_Site	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	7749013	38609853	12694713	452	18377										
TNRC6B	23112	broad.mit.edu	37	chr22	40661039	40661039	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	accctaaggctaaatctgttCaatcttccaactctactaca	3	13	4	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:40661039C>G	uc011aor.1	+	5	1016	c.805C>G	c.(805-807)CAA>GAA	p.Q269E	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Missense_Mutation_p.Q269E|TNRC6B_uc003ayo.2_Missense_Mutation_p.Q73E	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	269					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						TAAATCTGTTCAATCTTCCAA	0.453													0	0	0	0.00308	0	8	64										G	40661039	C	G	40661039	3	3	62	1	0	0	0	0	1	0	0	0	16338	827	29	1	944	1	TNRC6B	22	40661039	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2051186	40661039	10643527	453	18378										
TNRC6B	23112	broad.mit.edu	37	chr22	40662821	40662821	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccagctggagcagcgggccaCagcctgcaacacctaaggat	12	14	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:40662821C>T	uc011aor.1	+	5	2798	c.2587C>T	c.(2587-2589)CAG>TAG	p.Q863*	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.Q863*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.Q667*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	863	Pro-rich.				gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						CAGCGGGCCACAGCCTGCAAC	0.582													0	0	0	0.001984	0	6	23										T	40662821	C	T	40662821	4	4	62	1	0	0	0	0	0	1	0	0	16338	479	17	2	2726	2	TNRC6B	22	40662821	Nonsense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	1782	40662821	10641745	454	18379										
CHKB	1120	broad.mit.edu	37	chr22	51019955	51019955	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgctgacaacactggctctcGaagctcttgagttttcaatg	9	10	3	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:51019955G>A	uc003bms.2	-	4	693	c.475C>T	c.(475-477)CGA>TGA	p.R159*	CPT1B_uc003bmo.2_5'Flank|CPT1B_uc011asa.1_5'Flank|CPT1B_uc003bmn.2_5'Flank|CPT1B_uc011asb.1_5'Flank|CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Intron|CHKB-CPT1B_uc003bmu.2_Nonsense_Mutation_p.R38*|CHKB_uc003bmv.2_Nonsense_Mutation_p.R159*|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	159					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	ACTGGCTCTCGAAGCTCTTGA	0.572													0	0	0	0.001855	0	11	35										A	51019955	G	A	51019955	4	1	62	1	0	0	0	0	0	1	0	0	3348	1066	37	1	744	1	CHKB	22	51019955	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	10357134	51019955	284611	455	18380										
STS	412	broad.mit.edu	37	chrX	7268167	7268167	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gctgcggacagacacacccaGaccctgccagaggtgcccga	12	16	0	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:7268167G>C	uc004cry.3	+	10	1862	c.1617G>C	c.(1615-1617)CAG>CAC	p.Q539H		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	539	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GACACACCCAGACCCTGCCAG	0.542									Ichthyosis				0	0	0	0.00632	0	21	14										C	7268167	G	C	7268167	3	2	62	1	0	0	0	0	1	0	0	0	15331	933	33	1	1655	1	STS	23	7268167	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		7268167	148002393	456	18381										
TLR8	51311	broad.mit.edu	37	chrX	12938248	12938248	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	attaatatttccagaaacttCtctaaacttttgtctctacg	3	9	2	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:12938248C>G	uc004cve.2	+	2	1157	c.1089C>G	c.(1087-1089)TTC>TTG	p.F363L	TLR8_uc004cvd.2_Missense_Mutation_p.F381L	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	363	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CCAGAAACTTCTCTAAACTTT	0.393													0	0	0	0.007291	0	26	43										G	12938248	C	G	12938248	3	3	62	1	0	0	0	0	1	0	0	0	15954	912	32	1	1095	1	TLR8	23	12938248	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	5670081	12938248	142332312	457	18382										
TLR8	51311	broad.mit.edu	37	chrX	12938564	12938564	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	acccacattcgaacttttatCatttcacccgtcctttaata	2	13	2	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:12938564C>G	uc004cve.2	+	2	1473	c.1405C>G	c.(1405-1407)CAT>GAT	p.H469D	TLR8_uc004cvd.2_Missense_Mutation_p.H487D	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	469	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						GAACTTTTATCATTTCACCCG	0.398													0	0	0	0.008361	0	22	38										G	12938564	C	G	12938564	3	3	62	1	0	0	0	0	1	0	0	0	15954	826	29	1	1411	1	TLR8	23	12938564	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	316	12938564	142331996	458	18383										
FIGF	2277	broad.mit.edu	37	chrX	15371214	15371214	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tgttccagcaagtggattttCctcctgcaaaacacatttac	6	11	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:15371214C>T	uc004cwt.1	-	5	1227	c.718G>A	c.(718-720)GAA>AAA	p.E240K		NM_004469	NP_004460	O43915	VEGFD_HUMAN	vascular endothelial growth factor D	240	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					AGTGGATTTTCCTCCTGCAAA	0.264													0	0	0	0.008871	0	14	35										T	15371214	C	T	15371214	3	4	62	1	0	0	0	0	1	0	0	0	5889	864	30	1	358	1	FIGF	23	15371214	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	2432650	15371214	139899346	459	18384										
CXorf23	256643	broad.mit.edu	37	chrX	19973576	19973576	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtaggtttgttttcagtattCtgagttgagtcaagatgttc	11	4	3	3			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:19973576C>G	uc004czp.2	-	4	1383	c.1383G>C	c.(1381-1383)CAG>CAC	p.Q461H	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.Q26H|CXorf23_uc004czo.2_Missense_Mutation_p.Q411H	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	461						mitochondrion				lung(1)|skin(1)	2						TTTCAGTATTCTGAGTTGAGT	0.378													0	0	0	0.003163	0	12	29										G	19973576	C	G	19973576	3	3	62	1	0	0	0	0	1	0	0	0	4103	912	32	1	697	1	CXorf23	23	19973576	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	4602362	19973576	135296984	460	18385										
MAGEB1	4112	broad.mit.edu	37	chrX	30269617	30269617	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	cacgacttttagagcgcgttCtagagccccattcagcaggt	10	12	2	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:30269617C>G	uc004dcc.2	+	4	1327	c.1007C>G	c.(1006-1008)TCT>TGT	p.S336C	MAGEB1_uc004dcd.2_Missense_Mutation_p.S336C|MAGEB1_uc004dce.2_Missense_Mutation_p.S336C	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	336											0						AGAGCGCGTTCTAGAGCCCCA	0.507													0	0	0	0.00632	0	24	14										G	30269617	C	G	30269617	3	3	62	1	0	0	0	0	1	0	0	0	9172	913	32	1	1009	1	MAGEB1	23	30269617	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	10296041	30269617	125000943	461	18386										
PRICKLE3	4007	broad.mit.edu	37	chrX	49040229	49040229	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ggcacccaggcatactcctcCgatgcacagcctgagtcgtc	10	16	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:49040229C>A	uc004dmy.1	-	3	296	c.270G>T	c.(268-270)TCG>TCT	p.S90S	PRICKLE3_uc011mmv.1_Silent_p.S22S|PRICKLE3_uc011mmw.1_Silent_p.S22S|PRICKLE3_uc011mmx.1_Silent_p.S90S|PRICKLE3_uc011mmy.1_Silent_p.S90S	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	90	PET.						protein binding|zinc ion binding			breast(1)	1						CATACTCCTCCGATGCACAGC	0.617													1	0	4.74835e-14	0.010818	5.21335e-14	23	10										A	49040229	C	A	49040229	2	1	62	1	0	0	0	0	0	0	0	1	12488	639	23	4		4	PRICKLE3	23	49040229	Silent	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	18770612	49040229	106230331	462	18387										
PRICKLE3	4007	broad.mit.edu	37	chrX	49040246	49040246	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctccgatgcacagcctgagtCgtcgtcggagatggagtggc	15	11	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:49040246C>G	uc004dmy.1	-	3	279	c.253G>C	c.(253-255)GAC>CAC	p.D85H	PRICKLE3_uc011mmv.1_Missense_Mutation_p.D17H|PRICKLE3_uc011mmw.1_Missense_Mutation_p.D17H|PRICKLE3_uc011mmx.1_Missense_Mutation_p.D85H|PRICKLE3_uc011mmy.1_Missense_Mutation_p.D85H	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	85	PET.						protein binding|zinc ion binding			breast(1)	1						CAGCCTGAGTCGTCGTCGGAG	0.642													0	0	0	0.00623	0	30	15										G	49040246	C	G	49040246	3	3	62	1	0	0	0	0	1	0	0	0	12488	884	31	1	1622	1	PRICKLE3	23	49040246	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	17	49040246	106230314	463	18388										
FAM199X	139231	broad.mit.edu	37	chrX	103411483	103411483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	aaccatgtccgacgaggcctCggccatcacttcctacgaga	9	15	1	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:103411483C>T	uc004elw.2	+	1	183	c.17C>T	c.(16-18)TCG>TTG	p.S6L		NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	6										ovary(1)	1						GACGAGGCCTCGGCCATCACT	0.701													0	0	0	0.001168	0	5	1										T	103411483	C	T	103411483	3	4	62	1	0	0	0	0	1	0	0	0	5530	893	31	1	19	1	FAM199X	23	103411483	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	54371237	103411483	51859077	464	18389										
RGAG1	57529	broad.mit.edu	37	chrX	109695851	109695851	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ctctggagggttgtctgcatCgctaatgagagacacagctt	12	9	2	2	rs148619359		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:109695851C>T	uc004eor.1	+	3	2252	c.2006C>T	c.(2005-2007)TCG>TTG	p.S669L	RGAG1_uc011msr.1_Missense_Mutation_p.S669L	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	669										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TTGTCTGCATCGCTAATGAGA	0.512													0	0	0	0.00245	0	13	32										T	109695851	C	T	109695851	3	4	62	1	0	0	0	0	1	0	0	0	13274	893	31	1	2008	1	RGAG1	23	109695851	Missense_Mutation	SNP	C	TCGA-DK-A3IT-01A-31D-A20D-08	6284368	109695851	45574709	465	18390										
FAM70A	55026	broad.mit.edu	37	chrX	119402108	119402108	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccaaaacatacctgaaagtcAtaagcagaatatggtggcag	9	8	1	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:119402108A>G	uc004eso.3	-	9	1109	c.882T>C	c.(880-882)TAT>TAC	p.Y294Y	FAM70A_uc004esp.3_Silent_p.Y270Y|FAM70A_uc010nqo.2_Silent_p.Y186Y	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	294	Pro-rich.					integral to membrane				lung(1)|breast(1)	2						CCTGAAAGTCATAAGCAGAAT	0.413													0	0	0	0.01441	0	75	45										G	119402108	A	G	119402108	2	3	62	1	0	0	0	0	0	0	0	1	5605	224	8	5		5	FAM70A	23	119402108	Silent	SNP	A	TCGA-DK-A3IT-01A-31D-A20D-08	9706257	119402108	35868452	466	18391										
CETN2	1069	broad.mit.edu	37	chrX	151996453	151996453	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gacctctccatctccatctcGatcagcttcatcaatcattt	3	15	7	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:151996453G>A	uc004fgq.2	-	5	498	c.451C>T	c.(451-453)CGA>TGA	p.R151*	CETN2_uc004fgr.2_Nonsense_Mutation_p.R80*	NM_004344	NP_004335	P41208	CETN2_HUMAN	caltractin	151	2.|EF-hand 4.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCATCTCGATCAGCTTCA	0.358								Direct_reversal_of_damage|NER					0	0	0	0.007291	0	22	74										A	151996453	G	A	151996453	4	1	62	1	0	0	0	0	0	1	0	0	3275	1066	37	1	71	1	CETN2	23	151996453	Nonsense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	32594345	151996453	3274107	467	18392										
NSDHL	50814	broad.mit.edu	37	chrX	152014895	152014895	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	ccagcagttagcgagccaatGagagaccaagtcgcacggac	12	12	0	2			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:152014895G>A	uc004fgt.1	+	3	288	c.27G>A	c.(25-27)ATG>ATA	p.M9I	NSDHL_uc004fgs.1_Missense_Mutation_p.M9I	NM_001129765	NP_001123237	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	9					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity				0	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	GCGAGCCAATGAGAGACCAAG	0.408													0	0	0	0.009718	0	31	33										A	152014895	G	A	152014895	3	1	62	1	0	0	0	0	1	0	0	0	10670	1290	45	1	29	1	NSDHL	23	152014895	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	18442	152014895	3255665	468	18393										
HCFC1	3054	broad.mit.edu	37	chrX	153229678	153229678	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	gtgcccgagtcgaggacacgGagggggcccgtttttgggcg	19	10	0	0			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:153229678G>C	uc004fjp.2	-	3	928	c.400C>G	c.(400-402)CCG>GCG	p.P134A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	134	Kelch 2.			P->S: Eliminates VIC formation and association with VP16. Weak association with POU2F1. Unable to associate with CREBZF and BAP1. Unable to rescue proliferation in temperature-sensitive arrested cells.	cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGAGGACACGGAGGGGGCCCG	0.562													0	0	0	0.01441	0	56	38										C	153229678	G	C	153229678	3	2	62	1	0	0	0	0	1	0	0	0	6991	1174	41	1	5803	1	HCFC1	23	153229678	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08	1214783	153229678	2040882	469	18394										
USP9Y	8287	broad.mit.edu	37	chrY	14898191	14898191	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568376068376068	266	3.2180727317154e-108	4.22325503509959	4.82131069952355	3.57457031971909	4.60095553472954e-05	0.00029906210975742	203	tttggaccatgcaaaacttgGagaaggcaaacttagtccac	9	9	0	1			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrY:14898191G>T	uc004fst.1	+	23	4151	c.3206G>T	c.(3205-3207)GGA>GTA	p.G1069V	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	1069					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						GCAAAACTTGGAGAAGGCAAA	0.398													1	0	1.02788e-11	0.00499	1.10564e-11	14	51										T	14898191	G	T	14898191	3	4	62	1	0	0	0	0	1	0	0	0	17088	1174	41	3	3288	3	USP9Y	24	14898191	Missense_Mutation	SNP	G	TCGA-DK-A3IT-01A-31D-A20D-08		14898191	44475375	470	18395										
TAS1R3	83756	broad.mit.edu	37	chr1	1267276	1267276	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccccactcgtcagagctcgcCatggtcaccggcaagttctt	9	16	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:1267276C>T	uc010nyk.1	+	2	450	c.450C>T	c.(448-450)GCC>GCT	p.A150A		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	150	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CAGAGCTCGCCATGGTCACCG	0.677													0	0	0	0.012319	0	17	61										T	1267276	C	T	1267276	2	4	63	1	0	0	0	0	0	0	0	1	15561	581	21	2		2	TAS1R3	1	1267276	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		1267276	247983345	1	18396										
GNB1	2782	broad.mit.edu	37	chr1	1749278	1749278	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gactcagtgggctcttacctGagagagagttgcatctgcac	12	10	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:1749278G>T	uc001aif.2	-	4	426	c.94C>A	c.(94-96)CAG>AAG	p.Q32K	GNB1_uc009vky.2_Intron	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	32					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GCTCTTACCTGAGAGAGAGTT	0.547													1	0	0.00909568	0.009096	0.00928131	3	58										T	1749278	G	T	1749278	3	4	63	1	0	0	0	0	1	0	0	0	6515	1299	45	3	960	3	GNB1	1	1749278	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	482002	1749278	247501343	2	18397										
ICMT	23463	broad.mit.edu	37	chr1	6293642	6293642	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atccaaggacagacttttggGattattgactgctgtcacca	9	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:6293642G>A	uc001amk.2	-	3	419	c.346C>T	c.(346-348)CCC>TCC	p.P116S	ICMT_uc001aml.2_Missense_Mutation_p.P20S	NM_012405	NP_036537	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	116					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AGACTTTTGGGATTATTGACT	0.398													0	0	0	0.001984	0	6	74										A	6293642	G	A	6293642	3	1	63	1	0	0	0	0	1	0	0	0	7485	1174	41	1	520	1	ICMT	1	6293642	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4544364	6293642	242956979	3	18398										
SPEN	23013	broad.mit.edu	37	chr1	16262633	16262633	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcagattgtgcactccagcGgggagctgtttcaagagtac	13	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:16262633G>T	uc001axk.1	+	11	10102	c.9898G>T	c.(9898-9900)GGG>TGG	p.G3300W	SPEN_uc010obp.1_Missense_Mutation_p.G3259W	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3300	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCACTCCAGCGGGGAGCTGTT	0.627													1	0	5.3912e-06	0.006122	5.72517e-06	17	162										T	16262633	G	T	16262633	3	4	63	1	0	0	0	0	1	0	0	0	15037	1116	39	4	9940	4	SPEN	1	16262633	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	9968991	16262633	232987988	4	18399										
UBR4	23352	broad.mit.edu	37	chr1	19454159	19454159	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccagatttggtgcgggacatGaagacactcaggagtctcat	12	9	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:19454159G>A	uc001bbi.2	-	63	9190	c.9186C>T	c.(9184-9186)TTC>TTT	p.F3062F	UBR4_uc001bbk.1_Silent_p.F709F	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3062					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGCGGGACATGAAGACACTCA	0.488													0	0	0	0.008291	0	10	102										A	19454159	G	A	19454159	2	1	63	1	0	0	0	0	0	0	0	1	16901	1281	45	1		1	UBR4	1	19454159	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3191526	19454159	229796462	5	18400										
EIF4G3	8672	broad.mit.edu	37	chr1	21154159	21154159	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagatagcaagaccccagctCttccaacaggaagtaaaggt	9	11	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:21154159C>G	uc001bec.2	-	27	4308	c.4052G>C	c.(4051-4053)AGA>ACA	p.R1351T	EIF4G3_uc010odi.1_Missense_Mutation_p.R955T|EIF4G3_uc010odj.1_Missense_Mutation_p.R1350T|EIF4G3_uc009vpz.2_Missense_Mutation_p.R1071T|EIF4G3_uc001bed.2_Missense_Mutation_p.R1351T|EIF4G3_uc001bef.2_Missense_Mutation_p.R1387T|EIF4G3_uc001bee.2_Missense_Mutation_p.R1357T	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1351					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GACCCCAGCTCTTCCAACAGG	0.388													0	0	0	0.009096	0	3	55										G	21154159	C	G	21154159	3	3	63	1	0	0	0	0	1	0	0	0	5038	913	32	1	729	1	EIF4G3	1	21154159	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1700000	21154159	228096462	6	18401										
MYOM3	127294	broad.mit.edu	37	chr1	24418668	24418668	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cacgaggtcgactcaccgctCaatggtgtaggcagtgatgg	14	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:24418668C>T	uc001bin.3	-	11	1391	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	MYOM3_uc001bim.3_Missense_Mutation_p.E67K|MYOM3_uc001bio.2_Missense_Mutation_p.E410K|MYOM3_uc001bip.1_Missense_Mutation_p.E67K	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	410	Fibronectin type-III 1.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ACTCACCGCTCAATGGTGTAG	0.602													0	0	0	0.00245	0	10	75										T	24418668	C	T	24418668	3	4	63	1	0	0	0	0	1	0	0	0	10093	835	29	1	3193	1	MYOM3	1	24418668	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3264509	24418668	224831953	7	18402										
ARID1A	8289	broad.mit.edu	37	chr1	27092815	27092815	+	Frame_Shift_Del	DEL	C	C	-													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcatgatcaaccctcagggaCccccatattccatgggtgga							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:27092815delC	uc001bmv.1	+	9	3209	c.2836delC	c.(2836-2838)CCCfs	p.P946fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.P946fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.P946fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.P563fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	946					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCTCAGGGACCCCCATATTC	0.483			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													18	129	---	---								-	27092815	C	-	27092815	7	5	63	1	0	1	0	1	0	0	0	0	913	507	18	0	2870	0	ARID1A	1	27092815	Frame_Shift_Del	DEL	C	TCGA-DK-A3IU-01A-11D-A20D-08	2674147	27092815	222157806	8	18403										
PTPRF	5792	broad.mit.edu	37	chr1	44072610	44072610	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcagtcatcctcatcatcctCattgtcatcgccatcctctt	4	16	6	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:44072610C>G	uc001cjr.2	+	21	4168	c.3828C>G	c.(3826-3828)CTC>CTG	p.L1276L	PTPRF_uc001cjs.2_Silent_p.L1267L|PTPRF_uc001cju.2_Silent_p.L654L|PTPRF_uc009vwt.2_Silent_p.L836L|PTPRF_uc001cjv.2_Silent_p.L736L|PTPRF_uc001cjw.2_Silent_p.L502L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1276	Helical; (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCATCATCCTCATTGTCATCG	0.622													0	0	0	0.010729	0	10	128										G	44072610	C	G	44072610	2	3	63	1	0	0	0	0	0	0	0	1	12801	813	29	1		1	PTPRF	1	44072610	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	16979795	44072610	205178011	9	18404										
IPO13	9670	broad.mit.edu	37	chr1	44426671	44426671	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcccccaggcctctgctcttGacctcactcgacaggtgggc	10	17	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:44426671G>C	uc001ckx.2	+	13	3028	c.2233G>C	c.(2233-2235)GAC>CAC	p.D745H		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	745	HEAT 13.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTCTGCTCTTGACCTCACTCG	0.617													0	0	0	0.001168	0	6	60										C	44426671	G	C	44426671	3	2	63	1	0	0	0	0	1	0	0	0	7794	1290	45	1	2283	1	IPO13	1	44426671	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	354061	44426671	204823950	10	18405										
ATP6V0B	533	broad.mit.edu	37	chr1	44442265	44442265	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atctctaccactaccagcatCatcttctgtgaggctgtggc	8	13	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:44442265C>T	uc001cld.2	+	5	393	c.282C>T	c.(280-282)ATC>ATT	p.I94I	ATP6V0B_uc001clc.2_Silent_p.I94I|ATP6V0B_uc001cle.2_Silent_p.I47I|ATP6V0B_uc001clf.2_Silent_p.I47I|B4GALT2_uc001clg.2_5'Flank|B4GALT2_uc001clh.2_5'Flank	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	94	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CTACCAGCATCATCTTCTGTG	0.502													0	0	0	0.008291	0	8	88										T	44442265	C	T	44442265	2	4	63	1	0	0	0	0	0	0	0	1	1171	816	29	1		1	ATP6V0B	1	44442265	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	15594	44442265	204808356	11	18406										
LRRC40	55631	broad.mit.edu	37	chr1	70618118	70618118	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatagtatcaataaatacctGagatctaaaaaagtcaattt	4	5	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:70618118G>C	uc001der.1	-	12	1489	c.1437C>G	c.(1435-1437)CTC>CTG	p.L479L		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	479	LRR 16.									ovary(1)	1						ATAAATACCTGAGATCTAAAA	0.294													0	0	0	0.001168	0	4	33										C	70618118	G	C	70618118	2	2	63	1	0	0	0	0	0	0	0	1	8998	1277	45	1		1	LRRC40	1	70618118	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	26175853	70618118	178632503	12	18407										
TGFBR3	7049	broad.mit.edu	37	chr1	92185617	92185617	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agggagcccatcttctccctCttcattccagactctcctgg	7	16	5	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:92185617C>T	uc001doh.2	-	9	1712	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	TGFBR3_uc009wde.2_Missense_Mutation_p.E193K|TGFBR3_uc010osy.1_Missense_Mutation_p.E374K|TGFBR3_uc001doi.2_Missense_Mutation_p.E415K|TGFBR3_uc001doj.2_Missense_Mutation_p.E415K	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	416	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TCTTCTCCCTCTTCATTCCAG	0.577													0	0	0	0.001984	0	7	84										T	92185617	C	T	92185617	3	4	63	1	0	0	0	0	1	0	0	0	15820	922	32	1	1345	1	TGFBR3	1	92185617	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	21567499	92185617	157065004	13	18408										
VAV3	10451	broad.mit.edu	37	chr1	108417594	108417594	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttcctcattccaaacgtctCacaacaggccgtgagaaatg	7	12	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:108417594C>T	uc001dvk.1	-	2	304	c.250G>A	c.(250-252)GAG>AAG	p.E84K	VAV3_uc010ouw.1_Missense_Mutation_p.E84K|VAV3_uc001dvl.1_5'UTR|VAV3_uc010oux.1_Missense_Mutation_p.E84K	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	84	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CCAAACGTCTCACAACAGGCC	0.358													0	0	0	0.004482	0	7	54										T	108417594	C	T	108417594	3	4	63	1	0	0	0	0	1	0	0	0	17130	835	29	1	2422	1	VAV3	1	108417594	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	16231977	108417594	140833027	14	18409										
AKNAD1	254268	broad.mit.edu	37	chr1	109366068	109366068	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttgctatgatttgagtaattCtgtcctggagtgttgtatct	10	5	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:109366068C>T	uc001dwa.2	-	13	2360	c.2091G>A	c.(2089-2091)CAG>CAA	p.Q697Q	AKNAD1_uc010ovb.1_Silent_p.Q404Q|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	697										ovary(3)	3						TTGAGTAATTCTGTCCTGGAG	0.408													0	0	0	0.00308	0	7	70										T	109366068	C	T	109366068	2	4	63	1	0	0	0	0	0	0	0	1	464	912	32	1		1	AKNAD1	1	109366068	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	948474	109366068	139884553	15	18410										
KCND3	3752	broad.mit.edu	37	chr1	112524975	112524975	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agcagtccccgatgatctccGggaggatgccgtagaaggcc	14	12	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:112524975G>A	uc001ebu.1	-	2	854	c.374C>T	c.(373-375)CCG>CTG	p.P125L	KCND3_uc001ebv.1_Missense_Mutation_p.P125L	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	125	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GATGATCTCCGGGAGGATGCC	0.617													0	0	0	0.006214	0	9	103										A	112524975	G	A	112524975	3	1	63	1	0	0	0	0	1	0	0	0	8020	1116	39	2	1621	2	KCND3	1	112524975	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3158907	112524975	136725646	16	18411										
SLC16A1	6566	broad.mit.edu	37	chr1	113459918	113459918	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtttcaaacaatacggagctGagccacccgaaggcaaatcc	9	12	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:113459918G>C	uc001ecx.2	-	4	1942	c.1110C>G	c.(1108-1110)CTC>CTG	p.L370L	SLC16A1_uc001ecy.2_Silent_p.L370L|SLC16A1_uc001ecz.2_Silent_p.L370L	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	370	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	ATACGGAGCTGAGCCACCCGA	0.488													0	0	0	0.009096	0	3	51										C	113459918	G	C	113459918	2	2	63	1	0	0	0	0	0	0	0	1	14402	1277	45	1		1	SLC16A1	1	113459918	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	934943	113459918	135790703	17	18412										
MAGI3	260425	broad.mit.edu	37	chr1	114226103	114226103	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaaagctccatcaaatgctGaggccaaattattagagggt	10	8	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:114226103G>A	uc001edk.2	+	21	4094	c.3913G>A	c.(3913-3915)GAG>AAG	p.E1305K	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1330					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCAAATGCTGAGGCCAAATT	0.478													0	0	0	0.00308	0	7	94										A	114226103	G	A	114226103	3	1	63	1	0	0	0	0	1	0	0	0	9192	1291	45	1	4049	1	MAGI3	1	114226103	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	766185	114226103	135024518	18	18413										
PTPN22	26191	broad.mit.edu	37	chr1	114380651	114380651	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccacctccttggtttctctCtgctgtatcaattcaaaagg	6	12	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:114380651C>T	uc001eds.2	-	13	1501	c.1371G>A	c.(1369-1371)CAG>CAA	p.Q457Q	PTPN22_uc009wgq.2_Silent_p.Q402Q|PTPN22_uc010owo.1_Silent_p.Q213Q|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Silent_p.Q457Q|PTPN22_uc009wgs.2_Silent_p.Q330Q|PTPN22_uc001edu.2_Silent_p.Q457Q	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	457					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGTTTCTCTCTGCTGTATCA	0.373													0	0	0	0.008291	0	8	90										T	114380651	C	T	114380651	2	4	63	1	0	0	0	0	0	0	0	1	12787	912	32	1		1	PTPN22	1	114380651	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	154548	114380651	134869970	19	18414										
PTPN22	26191	broad.mit.edu	37	chr1	114380755	114380755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttagaattagaacatccctCaaacaaaagagagcccaaat	5	9	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:114380755C>G	uc001eds.2	-	13	1397	c.1267G>C	c.(1267-1269)GAG>CAG	p.E423Q	PTPN22_uc009wgq.2_Missense_Mutation_p.E368Q|PTPN22_uc010owo.1_Missense_Mutation_p.E179Q|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.E423Q|PTPN22_uc009wgs.2_Missense_Mutation_p.E296Q|PTPN22_uc001edu.2_Missense_Mutation_p.E423Q	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	423					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACATCCCTCAAACAAAAGA	0.388													0	0	0	0.004482	0	5	63										G	114380755	C	G	114380755	3	3	63	1	0	0	0	0	1	0	0	0	12787	835	29	1	1215	1	PTPN22	1	114380755	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	104	114380755	134869866	20	18415										
PTGFRN	5738	broad.mit.edu	37	chr1	117504176	117504176	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccaaaggactacagaggaaGacagaggcaattattactgt	10	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:117504176G>C	uc001egv.1	+	5	1662	c.1525G>C	c.(1525-1527)GAC>CAC	p.D509H		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	509	Extracellular (Potential).|Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TACAGAGGAAGACAGAGGCAA	0.463													0	0	0	0.001984	0	6	89										C	117504176	G	C	117504176	3	2	63	1	0	0	0	0	1	0	0	0	12750	942	33	1	1543	1	PTGFRN	1	117504176	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3123421	117504176	131746445	21	18416										
MAN1A2	10905	broad.mit.edu	37	chr1	118039474	118039474	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cacttggaaaaaaagatgggGcatttggcctgctttgctgg	13	7	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:118039474G>A	uc001ehd.1	+	10	2095	c.1374G>A	c.(1372-1374)GGG>GGA	p.G458G	MAN1A2_uc009whg.1_Silent_p.G248G	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	458	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AAAAGATGGGGCATTTGGCCT	0.438													0	0	0	0.00499	0	15	118										A	118039474	G	A	118039474	2	1	63	1	0	0	0	0	0	0	0	1	9211	1190	42	2		2	MAN1A2	1	118039474	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	535298	118039474	131211147	22	18417										
HAO2	51179	broad.mit.edu	37	chr1	119936422	119936422	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttttaggctgccggtcggtcGctgagatcaatcgaaacttg	12	9	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:119936422G>T	uc001ehq.1	+	9	1367	c.1015G>T	c.(1015-1017)GCT>TCT	p.A339S	HAO2_uc001ehr.1_Missense_Mutation_p.A339S	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	339	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CCGGTCGGTCGCTGAGATCAA	0.478													1	0	0.000151284	0.001855	0.000157588	11	168										T	119936422	G	T	119936422	3	4	63	1	0	0	0	0	1	0	0	0	6952	1087	38	4	1041	4	HAO2	1	119936422	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1896948	119936422	129314199	23	18418										
NBPF9	400818	broad.mit.edu	37	chr1	144617158	144617158	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtcttttctcagagtatgaaGagtgtaaagacctcataaga	9	6	3	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:144617158G>T	uc009wig.1	+	5	260	c.184G>T	c.(184-186)GAG>TAG	p.E62*	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_5'UTR|NBPF9_uc001eli.3_Intron|NBPF9_uc010oyf.1_5'UTR|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	62						cytoplasm					0						AGAGTATGAAGAGTGTAAAGA	0.527													1	0	0.000958276	0.007413	0.000986218	15	157										T	144617158	G	T	144617158	4	4	63	1	0	0	0	0	0	1	0	0	10199	943	33	3	188	3	NBPF9	1	144617158	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	24680736	144617158	104633463	24	18419										
PDE4DIP	9659	broad.mit.edu	37	chr1	144871824	144871824	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaggaagctggatggagctGagggcaatggtgcctgagga	19	6	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:144871824G>A	uc001elw.3	-	32	5429	c.5138C>T	c.(5137-5139)TCA>TTA	p.S1713L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.S720L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1713					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GGATGGAGCTGAGGGCAATGG	0.532			T	PDGFRB	MPD								0	0	0	0.00308	0	6	114										A	144871824	G	A	144871824	3	1	63	1	0	0	0	0	1	0	0	0	11643	1294	45	1	1954	1	PDE4DIP	1	144871824	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	254666	144871824	104378797	25	18420										
ECM1	1893	broad.mit.edu	37	chr1	150483939	150483939	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctcttgctctagtgggagGaagcaatgagccgattctgt	12	10	3	1	rs149230481		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:150483939G>A	uc001eus.2	+	7	914	c.715G>A	c.(715-717)GAA>AAA	p.E239K	ECM1_uc010pce.1_3'UTR|ECM1_uc010pcf.1_3'UTR|ECM1_uc001eut.2_Intron|ECM1_uc001euu.2_Missense_Mutation_p.E268K|ECM1_uc001euv.2_Missense_Mutation_p.E266K|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	239	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTAGTGGGAGGAAGCAATGAG	0.597													0	0	0	0.010818	0	26	177										A	150483939	G	A	150483939	3	1	63	1	0	0	0	0	1	0	0	0	4897	1175	41	1	741	1	ECM1	1	150483939	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5612115	150483939	98766682	26	18421										
FLG2	388698	broad.mit.edu	37	chr1	152324512	152324512	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catgagtagtttggtgtctcTtgtgaactgtggattctgac	12	6	2	3	rs150834303		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:152324512T>C	uc001ezw.3	-	3	5823	c.5750A>G	c.(5749-5751)AAG>AGG	p.K1917R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1917							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGTGTCTCTTGTGAACTGT	0.502													0	0	0	0.010504	0	19	269										C	152324512	T	C	152324512	3	2	63	1	0	0	0	0	1	0	0	0	5923	1609	56	5	1429	5	FLG2	1	152324512	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	1840573	152324512	96926109	27	18422										
INTS3	65123	broad.mit.edu	37	chr1	153701122	153701122	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gctgcagccatggagttgcaGaagggaaaaggggcggcagc	18	8	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:153701122G>A	uc009wom.2	+	2	233	c.12G>A	c.(10-12)CAG>CAA	p.Q4Q	INTS3_uc001fct.2_Silent_p.Q4Q|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	4					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGGAGTTGCAGAAGGGAAAAG	0.448													0	0	0	0.006214	0	8	68										A	153701122	G	A	153701122	2	1	63	1	0	0	0	0	0	0	0	1	7779	933	33	1		1	INTS3	1	153701122	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1376610	153701122	95549499	28	18423										
INTS3	65123	broad.mit.edu	37	chr1	153701160	153701160	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agcagcagcagctgcttcggGagcagcgggaggtggaggag	20	8	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:153701160G>T	uc009wom.2	+	2	271	c.50G>T	c.(49-51)GGA>GTA	p.G17V	INTS3_uc001fct.2_Missense_Mutation_p.G17V|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	17	Ala/Gly-rich.				DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCTGCTTCGggagcagcggga	0.423													1	0	1.58986e-06	0.008291	1.70343e-06	8	47										T	153701160	G	T	153701160	3	4	63	1	0	0	0	0	1	0	0	0	7779	1174	41	3	52	3	INTS3	1	153701160	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	38	153701160	95549461	29	18424										
GATAD2B	57459	broad.mit.edu	37	chr1	153784519	153784519	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgccgaagcgtatgatgtctCatgatggtctcttgtttact	10	8	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:153784519C>T	uc001fdb.3	-	9	1753	c.1509G>A	c.(1507-1509)ATG>ATA	p.M503I		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	503						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TATGATGTCTCATGATGGTCT	0.458													0	0	0	0.003163	0	9	155										T	153784519	C	T	153784519	3	4	63	1	0	0	0	0	1	0	0	0	6261	826	29	1	284	1	GATAD2B	1	153784519	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	83359	153784519	95466102	30	18425										
AQP10	89872	broad.mit.edu	37	chr1	154296214	154296214	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccaactgcgggattccactCaaccctgcccgggacctggg	12	16	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:154296214C>T	uc001feu.2	+	5	679	c.639C>T	c.(637-639)CTC>CTT	p.L213L	AQP10_uc001fev.2_Silent_p.L213L|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	213	Extracellular (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGATTCCACTCAACCCTGCCC	0.642													0	0	0	0.00308	0	6	71										T	154296214	C	T	154296214	2	4	63	1	0	0	0	0	0	0	0	1	822	813	29	1		1	AQP10	1	154296214	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	511695	154296214	94954407	31	18426										
DAP3	7818	broad.mit.edu	37	chr1	155695260	155695260	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaaacaccagttttgcttatCcagctatacgatatcttctg	5	10	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:155695260C>G	uc001flq.2	+	5	527	c.358C>G	c.(358-360)CCA>GCA	p.P120A	DAP3_uc001flr.2_Missense_Mutation_p.P120A|DAP3_uc001fls.2_Missense_Mutation_p.P120A|DAP3_uc010pgl.1_Missense_Mutation_p.P79A|DAP3_uc001flt.2_Missense_Mutation_p.P86A|DAP3_uc001flu.2_Missense_Mutation_p.P120A|DAP3_uc010pgm.1_Missense_Mutation_p.P86A	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	120					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TTTTGCTTATCCAGCTATACG	0.428													0	0	0	0.009535	0	25	160										G	155695260	C	G	155695260	3	3	63	1	0	0	0	0	1	0	0	0	4234	855	30	1	372	1	DAP3	1	155695260	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1399046	155695260	93555361	32	18427										
PMF1	11243	broad.mit.edu	37	chr1	156182917	156182917	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	accatttcgagggtgaagctCctcgacaccatggtggacac	11	12	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:156182917C>T	uc001fnq.2	+	1	134	c.111C>T	c.(109-111)CTC>CTT	p.L37L	PMF1_uc009wru.1_RNA|PMF1_uc001fnr.2_Silent_p.L37L|BGLAP_uc001fns.1_Silent_p.L37L	NM_007221	NP_009152	Q6P1K2	PMF1_HUMAN	polyamine-modulated factor 1	37					cell division|chromosome segregation|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytosol|MIS12/MIND type complex|transcription factor complex	leucine zipper domain binding|transcription coactivator activity				0	Hepatocellular(266;0.158)					GGGTGAAGCTCCTCGACACCA	0.577													0	0	0	0.00308	0	5	52										T	156182917	C	T	156182917	2	4	63	1	0	0	0	0	0	0	0	1	12133	842	30	1		1	PMF1	1	156182917	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	487657	156182917	93067704	33	18428										
BCAN	63827	broad.mit.edu	37	chr1	156618580	156618580	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggggcttgcctggtgtcaaGactctcttcctcttccccaa	10	14	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:156618580G>C	uc001fpp.2	+	6	1326	c.990G>C	c.(988-990)AAG>AAC	p.K330N	BCAN_uc001fpo.2_Missense_Mutation_p.K330N	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	330	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGGTGTCAAGACTCTCTTCC	0.617													0	0	0	0.003954	0	21	209										C	156618580	G	C	156618580	3	2	63	1	0	0	0	0	1	0	0	0	1345	933	33	1	1008	1	BCAN	1	156618580	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	435663	156618580	92632041	34	18429										
OR10R2	343406	broad.mit.edu	37	chr1	158450115	158450115	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atgctgccatttgtcaccctCtgcattaccccactcttatg	5	15	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:158450115C>T	uc010pik.1	+	1	448	c.448C>T	c.(448-450)CTG>TTG	p.L150L	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	150	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TTGTCACCCTCTGCATTACCC	0.468													0	0	0	0.01441	0	53	246										T	158450115	C	T	158450115	2	4	63	1	0	0	0	0	0	0	0	1	10917	912	32	1		1	OR10R2	1	158450115	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1831535	158450115	90800506	35	18430										
OR6N2	81442	broad.mit.edu	37	chr1	158747170	158747170	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatggttttcttctcactgaGaatattagacaacatcttag	6	7	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:158747170G>A	uc010pir.1	-	1	256	c.256C>T	c.(256-258)CTC>TTC	p.L86F		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TTCTCACTGAGAATATTAGAC	0.453													0	0	0	0.006214	0	9	146										A	158747170	G	A	158747170	3	1	63	1	0	0	0	0	1	0	0	0	11207	942	33	1	700	1	OR6N2	1	158747170	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	297055	158747170	90503451	36	18431										
AIM2	9447	broad.mit.edu	37	chr1	159035904	159035904	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttgctattataattattctCtttggaatgaatttatcttt	4	5	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:159035904C>G	uc001ftj.1	-	4	857	c.612G>C	c.(610-612)AAG>AAC	p.K204N		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	204	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					TAATTATTCTCTTTGGAATGA	0.358													0	0	0	0.008291	0	11	81										G	159035904	C	G	159035904	3	3	63	1	0	0	0	0	1	0	0	0	432	912	32	1	431	1	AIM2	1	159035904	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	288734	159035904	90214717	37	18432										
OR10J3	441911	broad.mit.edu	37	chr1	159284097	159284097	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catagcggtcatatcccatgActgtgagcaggaagcagttg	12	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:159284097A>G	uc010piu.1	-	1	353	c.353T>C	c.(352-354)GTC>GCC	p.V118A		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					ATATCCCATGACTGTGAGCAG	0.522													0	0	0	0.013537	0	9	118										G	159284097	A	G	159284097	3	3	63	1	0	0	0	0	1	0	0	0	10911	275	10	5	638	5	OR10J3	1	159284097	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	248193	159284097	89966524	38	18433										
VANGL2	57216	broad.mit.edu	37	chr1	160388962	160388962	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctggcactgctgtctttcctCacgcctctggccttcctgct	8	17	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:160388962C>G	uc001fwb.1	+	5	662	c.363C>G	c.(361-363)CTC>CTG	p.L121L	VANGL2_uc001fwc.1_Silent_p.L121L	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	121	Helical; Name=1; (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTCTTTCCTCACGCCTCTGG	0.662													0	0	0	0.00308	0	6	110										G	160388962	C	G	160388962	2	3	63	1	0	0	0	0	0	0	0	1	17117	813	29	1		1	VANGL2	1	160388962	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1104865	160388962	88861659	39	18434										
C1orf111	284680	broad.mit.edu	37	chr1	162343919	162343919	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcctggcagctgccggaggaGagcctgtctcccagccgggc	16	15	1	1	rs144886006		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:162343919G>A	uc001gbx.2	-	3	769	c.705C>T	c.(703-705)CTC>CTT	p.L235L		NM_182581	NP_872387	Q5T0L3	CA111_HUMAN	hypothetical protein LOC284680	235										ovary(1)	1	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			TGCCGGAGGAGAGCCTGTCTC	0.552													0	0	0	0.010729	0	10	243										A	162343919	G	A	162343919	2	1	63	1	0	0	0	0	0	0	0	1	1984	929	33	1		1	C1orf111	1	162343919	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1954957	162343919	86906702	40	18435										
UAP1	6675	broad.mit.edu	37	chr1	162549315	162549315	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagagaatgtaatcttttttCagcaaggaatgctccccgcc	8	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:162549315C>T	uc001gce.3	+	4	912	c.583C>T	c.(583-585)CAG>TAG	p.Q195*		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	195					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AATCTTTTTTCAGCAAGGAAT	0.358													0	0	0	0.006214	0	9	68										T	162549315	C	T	162549315	4	4	63	1	0	0	0	0	0	1	0	0	16822	827	29	1	593	1	UAP1	1	162549315	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	205396	162549315	86701306	41	18436										
RXRG	6258	broad.mit.edu	37	chr1	165380319	165380319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cctcactctcagctcgctctCggctcctctgtctttcttct	5	18	7	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:165380319C>T	uc001gda.2	-	5	950	c.650G>A	c.(649-651)CGA>CAA	p.R217Q		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	217	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	AGCTCGCTCTCGGCTCCTCTG	0.448													0	0	0	0.012319	0	19	57										T	165380319	C	T	165380319	3	4	63	1	0	0	0	0	1	0	0	0	13765	884	31	1	765	1	RXRG	1	165380319	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2831004	165380319	83870302	42	18437										
FMO3	2328	broad.mit.edu	37	chr1	171080103	171080103	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagcagatgaatgcaagattCaagcatgaaaactatggctt	9	6	1	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:171080103C>T	uc001ghi.2	+	6	903	c.792C>T	c.(790-792)TTC>TTT	p.F264F	FMO3_uc001ghh.2_Silent_p.F264F|FMO3_uc010pmb.1_Silent_p.F244F|FMO3_uc010pmc.1_Silent_p.F201F	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	264					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGCAAGATTCAAGCATGAAA	0.443													0	0	0	0.004482	0	6	100										T	171080103	C	T	171080103	2	4	63	1	0	0	0	0	0	0	0	1	5956	825	29	1		1	FMO3	1	171080103	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5699784	171080103	78170518	43	18438										
CEP350	9857	broad.mit.edu	37	chr1	179989421	179989421	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagctgcttctttgtccagcAgaattgaaagtgaagccaag	10	9	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:179989421A>C	uc001gnt.2	+	12	2895	c.2512A>C	c.(2512-2514)AGA>CGA	p.R838R	CEP350_uc009wxl.2_Silent_p.R837R|CEP350_uc001gnu.2_Silent_p.R672R	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	838						centrosome|nucleus|spindle				ovary(4)	4						TTTGTCCAGCAGAATTGAAAG	0.443													0	0	0	0.014323	0	20	126										C	179989421	A	C	179989421	2	2	63	1	0	0	0	0	0	0	0	1	3254	180	7	5		5	CEP350	1	179989421	Silent	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	8909318	179989421	69261200	44	18439										
HMCN1	83872	broad.mit.edu	37	chr1	185969231	185969231	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggtagagagttgacaggcaGagagcctggcatttctatct	13	7	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:185969231G>A	uc001grq.1	+	26	4158	c.3929G>A	c.(3928-3930)AGA>AAA	p.R1310K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1310	Ig-like C2-type 10.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTGACAGGCAGAGAGCCTGGC	0.398													0	0	0	0.004007	0	12	81										A	185969231	G	A	185969231	3	1	63	1	0	0	0	0	1	0	0	0	7220	942	33	1	4031	1	HMCN1	1	185969231	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5979810	185969231	63281390	45	18440										
CFH	3075	broad.mit.edu	37	chr1	196697623	196697623	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acacacagtctgcataaatgGaagatgggatccagaagtga	11	7	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:196697623G>C	uc001gtj.3	+	15	2624	c.2384G>C	c.(2383-2385)GGA>GCA	p.G795A		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	795	Sushi 13.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGCATAAATGGAAGATGGGAT	0.338													0	0	0	0.004482	0	6	85										C	196697623	G	C	196697623	3	2	63	1	0	0	0	0	1	0	0	0	3283	1174	41	1	2460	1	CFH	1	196697623	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	10728392	196697623	52552998	46	18441										
TNNI1	7135	broad.mit.edu	37	chr1	201383732	201383732	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttctcagcctcgcgctcctCgtgctcctgctcccagcatt	7	19	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:201383732C>T	uc010ppq.1	-	5	196	c.103G>A	c.(103-105)GAG>AAG	p.E35K	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_Missense_Mutation_p.E14K	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	35	Involved in binding TNC.				muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						TCGCGCTCCTCGTGCTCCTGC	0.662													0	0	0	0.001984	0	6	46										T	201383732	C	T	201383732	3	4	63	1	0	0	0	0	1	0	0	0	16323	893	31	1	476	1	TNNI1	1	201383732	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4686109	201383732	47866889	47	18442										
DSTYK	25778	broad.mit.edu	37	chr1	205138805	205138805	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatacaggaaaggagaaataCtttcggatttcctgaagctc	9	7	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:205138805C>G	uc001hbw.2	-	3	874	c.810G>C	c.(808-810)AAG>AAC	p.K270N	DSTYK_uc001hbx.2_Missense_Mutation_p.K270N|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	270						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						AGGAGAAATACTTTCGGATTT	0.448													0	0	0	0.009096	0	3	55										G	205138805	C	G	205138805	3	3	63	1	0	0	0	0	1	0	0	0	4785	564	20	4	2023	4	DSTYK	1	205138805	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3755073	205138805	44111816	48	18443										
RPS6KC1	26750	broad.mit.edu	37	chr1	213405500	213405500	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagtgaatacagcaggaacaGaaagaccatcatcccccgct	8	13	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:213405500G>C	uc010ptr.1	+	10	1286	c.1127G>C	c.(1126-1128)AGA>ACA	p.R376T	RPS6KC1_uc001hkd.2_Missense_Mutation_p.R364T|RPS6KC1_uc010pts.1_Missense_Mutation_p.R164T|RPS6KC1_uc010ptt.1_Missense_Mutation_p.R164T|RPS6KC1_uc010ptu.1_Missense_Mutation_p.R195T|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Missense_Mutation_p.R195T	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	376	Protein kinase 1.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AGCAGGAACAGAAAGACCATC	0.413													0	0	0	0.008291	0	10	88										C	213405500	G	C	213405500	3	2	63	1	0	0	0	0	1	0	0	0	13658	942	33	1	1165	1	RPS6KC1	1	213405500	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8266695	213405500	35845121	49	18444										
KCTD3	51133	broad.mit.edu	37	chr1	215768802	215768802	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagtgtggaatgctgtcactCagcactggcaggttagttta	13	7	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:215768802C>G	uc001hks.2	+	10	1216	c.922C>G	c.(922-924)CAG>GAG	p.Q308E	KCTD3_uc001hkt.2_Missense_Mutation_p.Q308E|KCTD3_uc010pub.1_Missense_Mutation_p.Q206E|KCTD3_uc009xdn.2_Missense_Mutation_p.Q60E	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	308	WD 2.					voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TGCTGTCACTCAGCACTGGCA	0.403													0	0	0	0.001168	0	6	64										G	215768802	C	G	215768802	3	3	63	1	0	0	0	0	1	0	0	0	8110	827	29	1	960	1	KCTD3	1	215768802	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2363302	215768802	33481819	50	18445										
USH2A	7399	broad.mit.edu	37	chr1	216500943	216500943	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atctgcttacctgtttgtaaGtgccacttggtataatcgaa	8	8	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:216500943G>T	uc001hku.1	-	5	1225	c.838C>A	c.(838-840)CTT>ATT	p.L280I	USH2A_uc001hkv.2_Missense_Mutation_p.L280I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	280	Laminin N-terminal.|Extracellular (Potential).		L -> F (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTTTGTAAGTGCCACTTGG	0.343										HNSCC(13;0.011)			1	0	0.00010058	0.013537	0.000104953	11	109										T	216500943	G	T	216500943	3	4	63	1	0	0	0	0	1	0	0	0	17033	1029	36	4	15056	4	USH2A	1	216500943	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	732141	216500943	32749678	51	18446										
C1orf131	128061	broad.mit.edu	37	chr1	231364906	231364906	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagtacatactttttctaggTtaaattcttgtgtatccaca	5	7	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:231364906T>A	uc001hun.1	-	3	537	c.500A>T	c.(499-501)AAC>ATC	p.N167I	C1orf131_uc001hul.2_Missense_Mutation_p.N167I|C1orf131_uc001hum.2_Missense_Mutation_p.N166I|C1orf131_uc010pwd.1_Missense_Mutation_p.N166I	NM_152379	NP_689592	Q8NDD1	CA131_HUMAN	hypothetical protein LOC128061	167										central_nervous_system(1)|skin(1)	2	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TTTTTCTAGGTTAAATTCTTG	0.199													0	0	0	0.009096	0	3	38										A	231364906	T	A	231364906	3	1	63	1	0	0	0	0	1	0	0	0	1998	1725	60	5	401	5	C1orf131	1	231364906	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	14863963	231364906	17885715	52	18447										
LYST	1130	broad.mit.edu	37	chr1	235969823	235969823	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggccagcataaaatttgctGagactctgaggagaatctga	11	7	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:235969823G>A	uc001hxj.2	-	6	2788	c.2613C>T	c.(2611-2613)CTC>CTT	p.L871L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.L871L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	871					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAAATTTGCTGAGACTCTGAG	0.398									Chediak-Higashi_syndrome				0	0	0	0.003163	0	14	106										A	235969823	G	A	235969823	2	1	63	1	0	0	0	0	0	0	0	1	9128	1277	45	1		1	LYST	1	235969823	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4604917	235969823	13280798	53	18448										
RYR2	6262	broad.mit.edu	37	chr1	237819281	237819281	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cccacaacctgttgatacctCaaagtatggactctttctat	5	12	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:237819281C>G	uc001hyl.1	+	53	8246	c.8126C>G	c.(8125-8127)TCA>TGA	p.S2709*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2709	Modulator (Potential).|Cytoplasmic (By similarity).|3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTGATACCTCAAAGTATGGA	0.358													0	0	0	0.00308	0	5	22										G	237819281	C	G	237819281	4	3	63	1	0	0	0	0	0	1	0	0	13769	838	29	1	8336	1	RYR2	1	237819281	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1849458	237819281	11431340	54	18449										
OPN3	23596	broad.mit.edu	37	chr1	241803278	241803278	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acgaaggtaaaggtgaccccGaagagggacaccagcaggtc	14	10	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:241803278G>A	uc001hza.2	-	1	424	c.279C>T	c.(277-279)TTC>TTT	p.F93F	OPN3_uc001hzb.2_RNA|OPN3_uc001hzc.2_RNA	NM_014322	NP_055137	Q9H1Y3	OPN3_HUMAN	opsin 3	93	Helical; Name=2; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity				0	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			AGGTGACCCCGAAGAGGGACA	0.622													0	0	0	0.000602	0	4	18										A	241803278	G	A	241803278	2	1	63	1	0	0	0	0	0	0	0	1	10881	1049	37	1		1	OPN3	1	241803278	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3983997	241803278	7447343	55	18450										
OR2M4	26245	broad.mit.edu	37	chr1	248402892	248402892	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catactttcctattcccatgTccttcgagccgtcatccaca	4	16	1	0	rs138162512		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:248402892T>A	uc010pzh.1	+	1	662	c.662T>A	c.(661-663)GTC>GAC	p.V221D		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TATTCCCATGTCCTTCGAGCC	0.483													0	0	0	0.001984	0	7	48										A	248402892	T	A	248402892	3	1	63	1	0	0	0	0	1	0	0	0	11012	1667	58	5	664	5	OR2M4	1	248402892	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	6599614	248402892	847729	56	18451										
OR2T2	401992	broad.mit.edu	37	chr1	248616329	248616329	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gataccatctacatctgtatCactgtccccaagatgctcca	5	14	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:248616329C>T	uc001iek.1	+	1	231	c.231C>T	c.(229-231)ATC>ATT	p.I77I		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACATCTGTATCACTGTCCCCA	0.522													0	0	0	0.006214	0	6	164										T	248616329	C	T	248616329	2	4	63	1	0	0	0	0	0	0	0	1	11020	816	29	1		1	OR2T2	1	248616329	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	213437	248616329	634292	57	18452										
WDR35	57539	broad.mit.edu	37	chr2	20138060	20138060	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggattgtcctctatgaactGagatgcatctttaattccaa	7	8	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:20138060G>A	uc002rdi.2	-	19	2170	c.2062C>T	c.(2062-2064)CAG>TAG	p.Q688*	WDR35_uc002rdj.2_Nonsense_Mutation_p.Q677*|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Nonsense_Mutation_p.Q253*|WDR35_uc002rdk.3_Nonsense_Mutation_p.Q253*	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	688										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTATGAACTGAGATGCATCT	0.418													0	0	0	0.001984	0	5	99										A	20138060	G	A	20138060	4	1	63	1	0	0	0	0	0	1	0	0	17286	1299	45	1	1523	1	WDR35	2	20138060	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		20138060	223061313	58	18453										
PFN4	375189	broad.mit.edu	37	chr2	24345319	24345319	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggtgatgctacacacaagctCcgctcctggattttgatgag	11	10	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:24345319C>G	uc002rfa.1	-	2	263	c.87G>C	c.(85-87)CGG>CGC	p.R29R	LOC375190_uc002rew.2_Intron|LOC375190_uc010ykl.1_5'Flank|LOC375190_uc002rfb.2_5'Flank	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	29					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACACAAGCTCCGCTCCTGGA	0.413													0	0	0	0.008291	0	8	103										G	24345319	C	G	24345319	2	3	63	1	0	0	0	0	0	0	0	1	11770	842	30	1		1	PFN4	2	24345319	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4207259	24345319	218854054	59	18454										
ITSN2	50618	broad.mit.edu	37	chr2	24484496	24484496	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggccttctttggagatacaGctttttcattttcacttgat	7	8	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:24484496G>A	uc002rfe.2	-	21	2729	c.2471C>T	c.(2470-2472)GCT>GTT	p.A824V	ITSN2_uc002rff.2_Missense_Mutation_p.A797V|ITSN2_uc002rfg.2_Missense_Mutation_p.A824V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	824				KAVSPK -> FAAAST (in Ref. 6; AAD00899).	endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGATACAGCTTTTTCATT	0.363													0	0	0	0.004482	0	8	66										A	24484496	G	A	24484496	3	1	63	1	0	0	0	0	1	0	0	0	7927	971	34	2	2753	2	ITSN2	2	24484496	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	139177	24484496	218714877	60	18455										
ZNF513	130557	broad.mit.edu	37	chr2	27600473	27600473	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccagggctggtgggccccgaGagctcaaaacagagggtggg	18	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:27600473G>A	uc002rkk.2	-	4	1765	c.1565C>T	c.(1564-1566)TCT>TTT	p.S522F	ZNF513_uc002rkj.2_Missense_Mutation_p.S460F	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	522					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGGCCCCGAGAGCTCAAAAC	0.632													0	0	0	0.000602	0	5	49										A	27600473	G	A	27600473	3	1	63	1	0	0	0	0	1	0	0	0	17955	942	33	1	64	1	ZNF513	2	27600473	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3115977	27600473	215598900	61	18456										
EIF2AK2	5610	broad.mit.edu	37	chr2	37374916	37374916	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acggtatgtattaagttcctCcatgaagaaacctgctgaaa	8	8	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:37374916C>G	uc010ynh.1	-	3	591	c.34G>C	c.(34-36)GAG>CAG	p.E12Q	EIF2AK2_uc010fab.1_Missense_Mutation_p.E12Q|EIF2AK2_uc010yng.1_Missense_Mutation_p.E12Q|EIF2AK2_uc010fac.2_Missense_Mutation_p.E12Q|EIF2AK2_uc010fad.2_Missense_Mutation_p.E12Q	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	12	DRBM 1.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TTAAGTTCCTCCATGAAGAAA	0.398													0	0	0	0.008871	0	16	127										G	37374916	C	G	37374916	3	3	63	1	0	0	0	0	1	0	0	0	4997	864	30	1	1681	1	EIF2AK2	2	37374916	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	9774443	37374916	205824457	62	18457										
PLEKHH2	130271	broad.mit.edu	37	chr2	43968150	43968150	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catcctttcctgtggctcctCaggcttcacctaaagaggaa	8	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:43968150C>G	uc010yny.1	+	21	3272	c.3189C>G	c.(3187-3189)CTC>CTG	p.L1063L	PLEKHH2_uc002rtf.3_Silent_p.L1062L	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1063	MyTH4.|Helical; (Potential).					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGTGGCTCCTCAGGCTTCACC	0.507													0	0	0	0.001855	0	12	76										G	43968150	C	G	43968150	2	3	63	1	0	0	0	0	0	0	0	1	12077	813	29	1		1	PLEKHH2	2	43968150	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	6593234	43968150	199231223	63	18458										
CCDC88A	55704	broad.mit.edu	37	chr2	55561583	55561583	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttctgcaatgtttgattttCcatctctaagtcttgtagtt	6	7	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:55561583C>T	uc002ryv.2	-	15	3216	c.2374G>A	c.(2374-2376)GAA>AAA	p.E792K	CCDC88A_uc010yoz.1_Missense_Mutation_p.E792K|CCDC88A_uc010ypa.1_Missense_Mutation_p.E792K|CCDC88A_uc010ypb.1_Missense_Mutation_p.E694K|CCDC88A_uc002ryu.2_Missense_Mutation_p.E75K|CCDC88A_uc002ryw.2_Missense_Mutation_p.E75K	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	792	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GTTTGATTTTCCATCTCTAAG	0.318													0	0	0	0.009096	0	3	40										T	55561583	C	T	55561583	3	4	63	1	0	0	0	0	1	0	0	0	2863	864	30	1	3313	1	CCDC88A	2	55561583	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	11593433	55561583	187637790	64	18459										
GKN2	200504	broad.mit.edu	37	chr2	69173523	69173523	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagcaggaaccaatccacgtCtttgatcagagactccagag	9	11	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:69173523C>T	uc002sfa.2	-	5	494	c.385G>A	c.(385-387)GAC>AAC	p.D129N	GKN2_uc002sfb.3_Missense_Mutation_p.D129N	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	129	BRICHOS.					extracellular region					0						CAATCCACGTCTTTGATCAGA	0.443													0	0	0	0.00245	0	11	207										T	69173523	C	T	69173523	3	4	63	1	0	0	0	0	1	0	0	0	6425	913	32	1	177	1	GKN2	2	69173523	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	13611940	69173523	174025850	65	18460										
ANXA4	307	broad.mit.edu	37	chr2	70037783	70037783	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cacatcgttcatgttccagcGagtgctggtgtctctgtcag	11	11	3	0	rs144937233		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:70037783G>A	uc002sfr.3	+	7	682	c.455G>A	c.(454-456)CGA>CAA	p.R152Q	ANXA4_uc010yqn.1_RNA|ANXA4_uc002sfs.3_Missense_Mutation_p.R130Q|ANXA4_uc010yqo.1_Missense_Mutation_p.R68Q	NM_001153	NP_001144	P09525	ANXA4_HUMAN	annexin IV	150	Annexin 2.				anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity				0						ATGTTCCAGCGAGTGCTGGTG	0.473													0	0	0	0.008291	0	7	56										A	70037783	G	A	70037783	3	1	63	1	0	0	0	0	1	0	0	0	720	1058	37	1	477	1	ANXA4	2	70037783	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	864260	70037783	173161590	66	18461										
CLEC4F	165530	broad.mit.edu	37	chr2	71043444	71043444	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttgaatacctgaatctgagTatctgtctggtccagacggc	10	10	3	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:71043444T>A	uc002shf.2	-	4	1146	c.1069A>T	c.(1069-1071)ACT>TCT	p.T357S	CLEC4F_uc010yqv.1_Missense_Mutation_p.T357S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	357	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TGAATCTGAGTATCTGTCTGG	0.408													0	0	0	0.001984	0	7	72										A	71043444	T	A	71043444	3	1	63	1	0	0	0	0	1	0	0	0	3516	1638	57	5	716	5	CLEC4F	2	71043444	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	1005661	71043444	172155929	67	18462										
CNNM4	26504	broad.mit.edu	37	chr2	97475114	97475114	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctcgcatggagaacagccctCagtttcccatagacgggtgc	11	13	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:97475114C>T	uc002swx.2	+	7	2286	c.2188C>T	c.(2188-2190)CAG>TAG	p.Q730*	CNNM4_uc010yuy.1_Missense_Mutation_p.S246L	NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	730					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane		p.Q730*(1)		breast(2)|ovary(1)	3						GAACAGCCCTCAGTTTCCCAT	0.577													0	0	0	0.001168	0	5	40										T	97475114	C	T	97475114	4	4	63	1	0	0	0	0	0	1	0	0	3615	827	29	1	2214	1	CNNM4	2	97475114	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	26431670	97475114	145724259	68	18463										
TBC1D8	11138	broad.mit.edu	37	chr2	101655103	101655103	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggctcgtgtcctccatcttCtcgatgctcaccacctgcgc	8	17	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:101655103C>T	uc010fiv.2	-	7	1181	c.1050G>A	c.(1048-1050)GAG>GAA	p.E350E	TBC1D8_uc010yvw.1_Silent_p.E365E|TBC1D8_uc002tau.3_Silent_p.E107E	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	350	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CCTCCATCTTCTCGATGCTCA	0.557													0	0	0	0.003163	0	11	100										T	101655103	C	T	101655103	2	4	63	1	0	0	0	0	0	0	0	1	15622	912	32	1		1	TBC1D8	2	101655103	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4179989	101655103	141544270	69	18464										
IL1F8	27177	broad.mit.edu	37	chr2	113783751	113783751	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catccaggtttatgcatgtgTgaattccaactagtttccag	8	9	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:113783751T>C	uc002tiq.1	-	5	424	c.320A>G	c.(319-321)CAC>CGC	p.H107R		NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	107					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						tatgcatgtgtgaattccaac	0													0	0	0	0.013537	0	9	67										C	113783751	T	C	113783751	3	2	63	1	0	0	0	0	1	0	0	0	7656	1696	59	5	182	5	IL1F8	2	113783751	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	12128648	113783751	129415622	70	18465										
FAM123C	205147	broad.mit.edu	37	chr2	131520580	131520580	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttcaccaggttctgggacaGtgtgaatcgctcagtgcgtc	12	11	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:131520580G>C	uc002trw.2	+	2	1125	c.935G>C	c.(934-936)AGT>ACT	p.S312T	FAM123C_uc010fmv.2_Missense_Mutation_p.S312T|FAM123C_uc010fms.1_Missense_Mutation_p.S312T|FAM123C_uc010fmt.1_Missense_Mutation_p.S312T|FAM123C_uc010fmu.1_Missense_Mutation_p.S312T	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	312										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TTCTGGGACAGTGTGAATCGC	0.647													0	0	0	0.00308	0	6	35										C	131520580	G	C	131520580	3	2	63	1	0	0	0	0	1	0	0	0	5424	1029	36	4	937	4	FAM123C	2	131520580	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	17736829	131520580	111678793	71	18466										
MCM6	4175	broad.mit.edu	37	chr2	136610439	136610439	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatcaattgattcctcaattCttgaatgcaaatctactatg	5	8	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:136610439C>T	uc002tuw.2	-	12	1749	c.1673G>A	c.(1672-1674)AGA>AAA	p.R558K		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	558					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TTCCTCAATTCTTGAATGCAA	0.368													0	0	0	0.001984	0	7	46										T	136610439	C	T	136610439	3	4	63	1	0	0	0	0	1	0	0	0	9391	913	32	1	816	1	MCM6	2	136610439	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5089859	136610439	106588934	72	18467										
MARCH7	64844	broad.mit.edu	37	chr2	160604796	160604796	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtcccgtagtaatgtaccatCagcttctgaagttcccgata	8	11	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:160604796C>G	uc002uax.2	+	5	1117	c.995C>G	c.(994-996)TCA>TGA	p.S332*	MARCH7_uc010foq.2_Nonsense_Mutation_p.S332*|MARCH7_uc010zcn.1_Nonsense_Mutation_p.S276*|MARCH7_uc010for.2_Nonsense_Mutation_p.S294*|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	332	Ser-rich.						ligase activity|zinc ion binding				0						AATGTACCATCAGCTTCTGAA	0.413													0	0	0	0.009096	0	3	39										G	160604796	C	G	160604796	4	3	63	1	0	0	0	0	0	1	0	0	9306	838	29	1	1009	1	MARCH7	2	160604796	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	23994357	160604796	82594577	73	18468										
LY75	4065	broad.mit.edu	37	chr2	160698844	160698844	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aacggtgatttttggaggttGagtattagggcacagtggta	15	3	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:160698844G>C	uc002ubc.3	-	24	3261	c.3192C>G	c.(3190-3192)CTC>CTG	p.L1064L	LY75_uc002ubb.3_Silent_p.L1064L|LY75_uc010fos.2_Silent_p.L1064L	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1064	Extracellular (Potential).|C-type lectin 6.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTGGAGGTTGAGTATTAGGG	0.403													0	0	0	0.004482	0	7	47										C	160698844	G	C	160698844	2	2	63	1	0	0	0	0	0	0	0	1	9099	1277	45	1		1	LY75	2	160698844	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	94048	160698844	82500529	74	18469										
SLC4A10	57282	broad.mit.edu	37	chr2	162813607	162813607	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccacagtcctctccatcactCatgtcaatagcctaaaactg	4	15	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:162813607C>T	uc002ubx.3	+	20	2834	c.2650C>T	c.(2650-2652)CAT>TAT	p.H884Y	SLC4A10_uc002uby.3_Missense_Mutation_p.H854Y|SLC4A10_uc010zcs.1_Missense_Mutation_p.H865Y	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	884	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CTCCATCACTCATGTCAATAG	0.493													0	0	0	0.000602	0	3	20										T	162813607	C	T	162813607	3	4	63	1	0	0	0	0	1	0	0	0	14651	826	29	1	2813	1	SLC4A10	2	162813607	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2114763	162813607	80385766	75	18470										
METTL5	29081	broad.mit.edu	37	chr2	170681089	170681089	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caggcgactctctagttcctTaagccttactttcttcattt	5	12	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:170681089T>C	uc002ufn.2	-	1	265	c.19A>G	c.(19-21)AAG>GAG	p.K7E	UBR3_uc010zdi.1_5'Flank|METTL5_uc002ufo.2_Missense_Mutation_p.K7E|METTL5_uc002ufp.2_Missense_Mutation_p.K7E|METTL5_uc002ufq.1_Missense_Mutation_p.K7E	NM_014168	NP_054887	Q9NRN9	METL5_HUMAN	methyltransferase like 5	7							methyltransferase activity|nucleic acid binding			central_nervous_system(1)	1						TCTAGTTCCTTAAGCCTTACT	0.468											OREG0015052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	12	98										C	170681089	T	C	170681089	3	2	63	1	0	0	0	0	1	0	0	0	9503	1763	61	5	638	5	METTL5	2	170681089	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	7867482	170681089	72518284	76	18471										
TTN	7273	broad.mit.edu	37	chr2	179611576	179611576	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggtcagaggttcaataaaaGatggaggcatttcattgtct	11	5	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:179611576G>C	uc002unb.2	-	46	15775	c.15551C>G	c.(15550-15552)TCT>TGT	p.S5184C	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8703							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAATAAAAGATGGAGGCAT	0.413													0	0	0	0.001168	0	4	79										C	179611576	G	C	179611576	3	2	63	1	0	0	0	0	1	0	0	0	16732	942	33	1	94746	1	TTN	2	179611576	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8930487	179611576	63587797	77	18472										
PLCL1	5334	broad.mit.edu	37	chr2	198948543	198948543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtctttcagcagcatgccatCggaaaagaaaattagcagtg	10	8	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:198948543C>T	uc010fsp.2	+	2	593	c.302C>T	c.(301-303)TCG>TTG	p.S101L	PLCL1_uc002uuv.3_Missense_Mutation_p.S22L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	101	Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AGCATGCCATCGGAAAAGAAA	0.383													0	0	0	0.001984	0	6	47										T	198948543	C	T	198948543	3	4	63	1	0	0	0	0	1	0	0	0	12039	893	31	1	308	1	PLCL1	2	198948543	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	19336967	198948543	44250830	78	18473										
AOX1	316	broad.mit.edu	37	chr2	201505863	201505863	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaatcttggccctggacatgGagcattacagcaatgcaggc	12	10	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:201505863G>C	uc002uvx.2	+	24	2712	c.2611G>C	c.(2611-2613)GAG>CAG	p.E871Q	AOX1_uc010zhf.1_Missense_Mutation_p.E427Q|AOX1_uc010fsu.2_Missense_Mutation_p.E237Q	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	871					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCTGGACATGGAGCATTACAG	0.443													0	0	0	0.009096	0	3	45										C	201505863	G	C	201505863	3	2	63	1	0	0	0	0	1	0	0	0	729	1175	41	1	2705	1	AOX1	2	201505863	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2557320	201505863	41693510	79	18474										
CASP10	843	broad.mit.edu	37	chr2	202073797	202073797	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttttgtttttaaacagagatCctgagtcatgtgttccagtg	9	6	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:202073797C>T	uc002uxl.1	+	9	1345	c.927C>T	c.(925-927)ATC>ATT	p.I309I	CASP10_uc002uxj.1_Silent_p.I309I|CASP10_uc002uxk.1_Silent_p.I266I|CASP10_uc010fta.1_Silent_p.I242I|CASP10_uc002uxm.1_Silent_p.I266I|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	309					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						AAACAGAGATCCTGAGTCATG	0.264													0	0	0	0.001168	0	6	42										T	202073797	C	T	202073797	2	4	63	1	0	0	0	0	0	0	0	1	2669	845	30	1		1	CASP10	2	202073797	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	567934	202073797	41125576	80	18475										
CDK5R2	8941	broad.mit.edu	37	chr2	219825385	219825385	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aacgagatctcctacccactCaagcccttcctcgtggagcc	7	17	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:219825385C>G	uc002vjf.2	+	1	988	c.843C>G	c.(841-843)CTC>CTG	p.L281L		NM_003936	NP_003927	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2	281					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTACCCACTCAAGCCCTTCC	0.677													0	0	0	0.001984	0	6	120										G	219825385	C	G	219825385	2	3	63	1	0	0	0	0	0	0	0	1	3144	813	29	1		1	CDK5R2	2	219825385	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	17751588	219825385	23373988	81	18476										
DNER	92737	broad.mit.edu	37	chr2	230450662	230450662	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggggtcacacttcgtccatcTatgagggagcactgttggaa	13	9	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:230450662T>C	uc002vpv.2	-	4	906	c.759A>G	c.(757-759)ATA>ATG	p.I253M	DNER_uc010zly.1_Translation_Start_Site	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	253	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTCGTCCATCTATGAGGGAGC	0.517													0	0	0	0.004482	0	8	58										C	230450662	T	C	230450662	3	2	63	1	0	0	0	0	1	0	0	0	4667	1512	53	5	1494	5	DNER	2	230450662	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	10625277	230450662	12748711	82	18477										
HTR2B	3357	broad.mit.edu	37	chr2	231988456	231988456	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaattgtgctttgaagttcaGacactctgtaagagagagcc	11	7	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:231988456G>C	uc002vro.2	-	2	528	c.23C>G	c.(22-24)TCT>TGT	p.S8C	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Missense_Mutation_p.S8C	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	8	Extracellular (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	TTGAAGTTCAGACACTCTGTA	0.423													0	0	0	0.007413	0	15	111										C	231988456	G	C	231988456	3	2	63	1	0	0	0	0	1	0	0	0	7442	942	33	1	1434	1	HTR2B	2	231988456	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1537794	231988456	11210917	83	18478										
ATG16L1	55054	broad.mit.edu	37	chr2	234191385	234191385	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccgaatctggactgtggatGattatcgattacgggtaaga	13	6	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:234191385G>A	uc002vty.2	+	12	1446	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N	ATG16L1_uc002vtx.1_Missense_Mutation_p.D234N|ATG16L1_uc002vua.2_Missense_Mutation_p.D378N|ATG16L1_uc002vub.2_Missense_Mutation_p.D255N|ATG16L1_uc002vtz.2_Missense_Mutation_p.D218N|ATG16L1_uc002vud.3_Missense_Mutation_p.D313N	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	397	WD 2.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GACTGTGGATGATTATCGATT	0.413													0	0	0	0.008291	0	8	75										A	234191385	G	A	234191385	3	1	63	1	0	0	0	0	1	0	0	0	1091	1290	45	1	1235	1	ATG16L1	2	234191385	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2202929	234191385	9007988	84	18479										
CHL1	10752	broad.mit.edu	37	chr3	432754	432754	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gttccttccttagatgccttTagtgaatttcatttaacagt	6	8	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:432754T>C	uc003bou.2	+	21	2926	c.2655T>C	c.(2653-2655)TTT>TTC	p.F885F	CHL1_uc003bot.2_Silent_p.F901F|CHL1_uc003bow.1_Silent_p.F885F|CHL1_uc011asi.1_Silent_p.F901F	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	885	Fibronectin type-III 3.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TAGATGCCTTTAGTGAATTTC	0.383													0	0	0	0.004007	0	13	46										C	432754	T	C	432754	2	2	63	1	0	0	0	0	0	0	0	1	3349	1751	61	5		5	CHL1	3	432754	Silent	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08		432754	197589676	85	18480										
CNTN6	27255	broad.mit.edu	37	chr3	1367618	1367618	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atacatggttaaaaaatggtGaacgactcaacccagaggta	9	7	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:1367618G>A	uc003boz.2	+	9	1333	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	CNTN6_uc011asj.1_Missense_Mutation_p.E284K|CNTN6_uc003bpa.2_Missense_Mutation_p.E356K	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	356	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAAAATGGTGAACGACTCAA	0.353													0	0	0	0.004672	0	3	56										A	1367618	G	A	1367618	3	1	63	1	0	0	0	0	1	0	0	0	3645	1291	45	1	1096	1	CNTN6	3	1367618	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	934864	1367618	196654812	86	18481										
C3orf20	84077	broad.mit.edu	37	chr3	14798893	14798893	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcagagggaaggcccgcgaGgggcgcagccccaccaggtg	18	13	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:14798893G>A	uc003byy.2	+	13	2360	c.1956G>A	c.(1954-1956)GAG>GAA	p.E652E	C3orf20_uc003byz.2_Silent_p.E530E|C3orf20_uc003bza.2_Silent_p.E530E|C3orf20_uc003bzb.1_Silent_p.E153E|C3orf20_uc011avj.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	652						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						AGGCCCGCGAGGGGCGCAGCC	0.667													0	0	0	0.004672	0	3	13										A	14798893	G	A	14798893	2	1	63	1	0	0	0	0	0	0	0	1	2213	991	35	2		2	C3orf20	3	14798893	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	13431275	14798893	183223537	87	18482										
SLC4A7	9497	broad.mit.edu	37	chr3	27436152	27436152	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aacttttaagctgttgacatGacttattgacaacactgttg	7	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:27436152G>A	uc003cdv.2	-	20	3018	c.2947C>T	c.(2947-2949)CAT>TAT	p.H983Y	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.H864Y|SLC4A7_uc011aww.1_Missense_Mutation_p.H992Y|SLC4A7_uc011awx.1_Missense_Mutation_p.H979Y|SLC4A7_uc011awy.1_Missense_Mutation_p.H975Y|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.H864Y|SLC4A7_uc011axb.1_Missense_Mutation_p.H979Y|SLC4A7_uc010hfl.2_Missense_Mutation_p.H533Y|SLC4A7_uc003cdw.2_Missense_Mutation_p.H859Y	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	983	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CTGTTGACATGACTTATTGAC	0.443													0	0	0	0.00278	0	19	77										A	27436152	G	A	27436152	3	1	63	1	0	0	0	0	1	0	0	0	14658	1290	45	1	721	1	SLC4A7	3	27436152	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	12637259	27436152	170586278	88	18483										
EOMES	8320	broad.mit.edu	37	chr3	27763709	27763709	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgctcccgccgctgccgcctCgcgcactctccagcgggtag	12	20	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:27763709C>T	uc003cdx.2	-	1	77	c.77G>A	c.(76-78)CGA>CAA	p.R26Q	EOMES_uc003cdy.3_Missense_Mutation_p.R26Q|EOMES_uc010hfn.2_Missense_Mutation_p.R26Q|EOMES_uc011axc.1_Intron	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	26					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						GCTGCCGCCTCGCGCACTCTC	0.637													0	0	0	0.009096	0	4	9										T	27763709	C	T	27763709	3	4	63	1	0	0	0	0	1	0	0	0	5147	884	31	1	2007	1	EOMES	3	27763709	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	327557	27763709	170258721	89	18484										
ZNF35	7584	broad.mit.edu	37	chr3	44700638	44700638	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtgggaaggccttcattcaGagtgcaaacctcgttgtgca	12	9	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:44700638G>C	uc003cnq.2	+	4	1004	c.783G>C	c.(781-783)CAG>CAC	p.Q261H	ZNF35_uc003cnr.2_Missense_Mutation_p.Q101H	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	261	C2H2-type 2.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		CCTTCATTCAGAGTGCAAACC	0.458													0	0	0	0.004482	0	7	55										C	44700638	G	C	44700638	3	2	63	1	0	0	0	0	1	0	0	0	17859	933	33	1	793	1	ZNF35	3	44700638	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	16936929	44700638	153321792	90	18485										
LRRC2	79442	broad.mit.edu	37	chr3	46586552	46586552	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcaccgtccagtgctccccaGaaagttcaaacacaaacgca	6	15	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:46586552G>A	uc010hji.2	-	3	681	c.317C>T	c.(316-318)TCT>TTT	p.S106F	LRRC2_uc003cpu.3_Missense_Mutation_p.S106F	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	106										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		GTGCTCCCCAGAAAGTTCAAA	0.537													0	0	0	0.012213	0	26	276										A	46586552	G	A	46586552	3	1	63	1	0	0	0	0	1	0	0	0	8976	942	33	1	826	1	LRRC2	3	46586552	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1885914	46586552	151435878	91	18486										
ALS2CL	259173	broad.mit.edu	37	chr3	46712990	46712990	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcccttacctccagggctgtGagcaggaagtcatacaggcc	11	13	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:46712990G>A	uc003cqa.1	-	25	2959	c.2769C>T	c.(2767-2769)CTC>CTT	p.L923L	ALS2CL_uc003cpx.1_Silent_p.L270L|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Silent_p.L438L|ALS2CL_uc003cqb.1_Silent_p.L923L|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	923	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CCAGGGCTGTGAGCAGGAAGT	0.592													0	0	0	0.000602	0	5	68										A	46712990	G	A	46712990	2	1	63	1	0	0	0	0	0	0	0	1	551	1277	45	1		1	ALS2CL	3	46712990	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	126438	46712990	151309440	92	18487										
SETD2	29072	broad.mit.edu	37	chr3	47155366	47155366	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtaattaaaaaagaacttacGaaggaaggtctttggcagct	10	5	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:47155366G>A	uc003cqs.2	-	5	4768	c.4715C>T	c.(4714-4716)TCG>TTG	p.S1572L	SETD2_uc003cqv.2_Missense_Mutation_p.S1561L	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1572	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAGAACTTACGAAGGAAGGTC	0.279			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.004672	0	3	56										A	47155366	G	A	47155366	3	1	63	1	0	0	0	0	1	0	0	0	14131	1072	37	1	3047	1	SETD2	3	47155366	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	442376	47155366	150867064	93	18488										
SMARCC1	6599	broad.mit.edu	37	chr3	47777526	47777526	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agtgattgtgtctattacctGatgtcgtttgatgatatctt	9	5	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:47777526G>C	uc003crq.2	-	5	692	c.574C>G	c.(574-576)CAG>GAG	p.Q192E	SMARCC1_uc011bbd.1_Missense_Mutation_p.Q83E	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	192					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TCTATTACCTGATGTCGTTTG	0.348													0	0	0	0.009096	0	3	58										C	47777526	G	C	47777526	3	2	63	1	0	0	0	0	1	0	0	0	14775	1299	45	1	2839	1	SMARCC1	3	47777526	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	622160	47777526	150244904	94	18489										
QRICH1	54870	broad.mit.edu	37	chr3	49114384	49114384	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttccttcatcctgtgttgcgGgacagaccgtgcctttactc	9	13	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:49114384G>A	uc010hkq.2	-	3	363	c.67C>T	c.(67-69)CCG>TCG	p.P23S	QRICH1_uc003cvu.2_Missense_Mutation_p.P23S|QRICH1_uc003cvv.2_Missense_Mutation_p.P23S	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	23	CARD.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CTGTGTTGCGGGACAGACCGT	0.488													0	0	0	0.004672	0	3	139										A	49114384	G	A	49114384	3	1	63	1	0	0	0	0	1	0	0	0	12879	1232	43	2	2299	2	QRICH1	3	49114384	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1336858	49114384	148908046	95	18490										
APEH	327	broad.mit.edu	37	chr3	49716346	49716346	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgctggtcagctgacagccaGagagtggtctttgactcggc	14	10	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:49716346G>A	uc003cxf.2	+	12	1522	c.1122G>A	c.(1120-1122)CAG>CAA	p.Q374Q	APEH_uc010hkw.1_Silent_p.Q374Q	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	374					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTGACAGCCAGAGAGTGGTCT	0.602													0	0	0	0.004482	0	7	91										A	49716346	G	A	49716346	2	1	63	1	0	0	0	0	0	0	0	1	768	933	33	1		1	APEH	3	49716346	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	601962	49716346	148306084	96	18491										
SLC38A3	10991	broad.mit.edu	37	chr3	50252990	50252990	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgcaggcatccgtgcctatGagcagctgggctaccgtgcc	13	14	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:50252990G>A	uc003cyn.3	+	6	529	c.388G>A	c.(388-390)GAG>AAG	p.E130K	SLC38A3_uc011bdl.1_Missense_Mutation_p.E105K|SLC38A3_uc011bdm.1_Missense_Mutation_p.E61K	NM_006841	NP_006832	Q99624	S38A3_HUMAN	solute carrier family 38, member 3	130					cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CCGTGCCTATGAGCAGCTGGG	0.627													0	0	0	0.000602	0	4	52										A	50252990	G	A	50252990	3	1	63	1	0	0	0	0	1	0	0	0	14605	1291	45	1	406	1	SLC38A3	3	50252990	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	536644	50252990	147769440	97	18492										
IFRD2	7866	broad.mit.edu	37	chr3	50327428	50327428	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagcagaggctgcaggctgtGaaacagctcctcacccttag	11	13	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:50327428G>A	uc011bdp.1	-	5	799	c.670C>T	c.(670-672)CAC>TAC	p.H224Y	IFRD2_uc003czb.2_Missense_Mutation_p.H326Y	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	224							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGCAGGCTGTGAAACAGCTCC	0.637													0	0	0	0.000602	0	5	14										A	50327428	G	A	50327428	3	1	63	1	0	0	0	0	1	0	0	0	7554	1290	45	1	882	1	IFRD2	3	50327428	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	74438	50327428	147695002	98	18493										
CISH	1154	broad.mit.edu	37	chr3	50645378	50645378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggccaggatgcgtggcctgGacaagcagttggagtccaga	16	9	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:50645378G>A	uc003dax.2	-	3	618	c.437C>T	c.(436-438)TCC>TTC	p.S146F	CISH_uc010hlq.2_Missense_Mutation_p.S163F	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	146	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GCGTGGCCTGGACAAGCAGTT	0.582													0	0	0	0.004672	0	3	44										A	50645378	G	A	50645378	3	1	63	1	0	0	0	0	1	0	0	0	3437	1174	41	1	343	1	CISH	3	50645378	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	317950	50645378	147377052	99	18494										
RAD54L2	23132	broad.mit.edu	37	chr3	51664777	51664777	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcacattgtggacagcagtGaatctgtcagtgaagatgat	12	6	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:51664777G>A	uc011bdt.1	+	6	780	c.655G>A	c.(655-657)GAA>AAA	p.E219K	RAD54L2_uc003dbh.2_5'UTR|RAD54L2_uc011bdu.1_5'UTR|RAD54L2_uc003dbj.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	219						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GGACAGCAGTGAATCTGTCAG	0.488													0	0	0	0.001168	0	4	36										A	51664777	G	A	51664777	3	1	63	1	0	0	0	0	1	0	0	0	12994	1291	45	1	673	1	RAD54L2	3	51664777	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1019399	51664777	146357653	100	18495										
PPM1M	132160	broad.mit.edu	37	chr3	52282434	52282434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagggggatgacttgggacaGaaggttttgttcagggatca	16	4	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:52282434G>C	uc003ddf.3	+	6	761	c.396G>C	c.(394-396)CAG>CAC	p.Q132H	PPM1M_uc011bed.1_Missense_Mutation_p.Q293H|PPM1M_uc010hmd.2_Missense_Mutation_p.Q132H|PPM1M_uc003ddg.3_Missense_Mutation_p.Q81H|PPM1M_uc003ddh.3_5'Flank			Q96MI6	PPM1M_HUMAN	RecName: Full=Protein phosphatase 1M;          EC=3.1.3.16; AltName: Full=Protein phosphatase 2C isoform eta;          Short=PP2C-eta;          Short=PP2CE;	132	PP2C-like.				protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding				0				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		ACTTGGGACAGAAGGTTTTGT	0.612													0	0	0	0.009096	0	3	27										C	52282434	G	C	52282434	3	2	63	1	0	0	0	0	1	0	0	0	12345	933	33	1	410	1	PPM1M	3	52282434	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	617657	52282434	145739996	101	18496										
ITIH3	3699	broad.mit.edu	37	chr3	52835027	52835027	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagaatgtgcggaatgccatCgggggcaagttccccttgta	14	9	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:52835027C>T	uc003dfv.2	+	11	1284	c.1248C>T	c.(1246-1248)ATC>ATT	p.I416I	ITIH3_uc011bek.1_Silent_p.I416I	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	416	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GGAATGCCATCGGGGGCAAGT	0.542													0	0	0	0.007291	0	25	172										T	52835027	C	T	52835027	2	4	63	1	0	0	0	0	0	0	0	1	7905	874	31	1		1	ITIH3	3	52835027	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	552593	52835027	145187403	102	18497										
OR5K1	26339	broad.mit.edu	37	chr3	98189002	98189002	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcttgtgttgatccttatatCaatgaactggttctattcat	6	7	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:98189002C>T	uc003dsm.2	+	1	582	c.582C>T	c.(580-582)ATC>ATT	p.I194I		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						ATCCTTATATCAATGAACTGG	0.333													0	0	0	0.00245	0	14	159										T	98189002	C	T	98189002	2	4	63	1	0	0	0	0	0	0	0	1	11166	816	29	1		1	OR5K1	3	98189002	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	45353975	98189002	99833428	103	18498										
GUCA1C	9626	broad.mit.edu	37	chr3	108626914	108626914	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccagccttgtcaggagatttGgaggagtctgtctccatgtc	12	10	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:108626914G>T	uc003dxj.2	-	4	653	c.585C>A	c.(583-585)TCC>TCA	p.S195S	GUCA1C_uc003dxk.2_3'UTR	NM_005459	NP_005450	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	195					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						CAGGAGATTTGGAGGAGTCTG	0.453													1	0	7.03913e-09	0.013537	7.63739e-09	7	38										T	108626914	G	T	108626914	2	4	63	1	0	0	0	0	0	0	0	1	6890	1335	47	4		4	GUCA1C	3	108626914	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	10437912	108626914	89395516	104	18499										
PHLDB2	90102	broad.mit.edu	37	chr3	111603863	111603863	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttgagctcaggggctttaccCtataaaacctctgcttctga	8	11	3	2	rs142557577		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:111603863C>T	uc010hqa.2	+	2	1350	c.939C>T	c.(937-939)CCC>CCT	p.P313P	PHLDB2_uc003dyc.2_Silent_p.P340P|PHLDB2_uc003dyd.2_Silent_p.P313P|PHLDB2_uc003dyg.2_Silent_p.P313P|PHLDB2_uc003dyh.2_Silent_p.P313P|PHLDB2_uc003dye.3_Silent_p.P313P|PHLDB2_uc003dyf.3_Silent_p.P313P	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	313						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GGGCTTTACCCTATAAAACCT	0.448													0	0	0	0.001855	0	12	53										T	111603863	C	T	111603863	2	4	63	1	0	0	0	0	0	0	0	1	11852	668	24	2		2	PHLDB2	3	111603863	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2976949	111603863	86418567	105	18500										
UROC1	131669	broad.mit.edu	37	chr3	126208126	126208126	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcatcttcctcacctgcacaGaaggcagagccgtcgtaaat	8	13	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:126208126G>A	uc003eiz.1	-	17	1733	c.1701C>T	c.(1699-1701)TTC>TTT	p.F567F	UROC1_uc010hsi.1_Silent_p.F627F	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	567					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		CACCTGCACAGAAGGCAGAGC	0.468													0	0	0	0.003163	0	10	145										A	126208126	G	A	126208126	2	1	63	1	0	0	0	0	0	0	0	1	17025	933	33	1		1	UROC1	3	126208126	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	14604263	126208126	71814304	106	18501										
AMOTL2	51421	broad.mit.edu	37	chr3	134085127	134085127	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtgtgactggctctcacctCtaagatcccggttgaagtct	10	11	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:134085127C>G	uc003eqf.2	-	4	1475	c.1358G>C	c.(1357-1359)AGA>ACA	p.R453T	AMOTL2_uc003eqg.1_Missense_Mutation_p.R395T|AMOTL2_uc003eqh.1_Missense_Mutation_p.R395T|AMOTL2_uc003eqe.1_Missense_Mutation_p.R20T	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	395	Potential.									large_intestine(1)	1						GCTCTCACCTCTAAGATCCCG	0.498													0	0	0	0.01441	0	39	359										G	134085127	C	G	134085127	3	3	63	1	0	0	0	0	1	0	0	0	584	913	32	1	1186	1	AMOTL2	3	134085127	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	7877001	134085127	63937303	107	18502										
EPHB1	2047	broad.mit.edu	37	chr3	134851765	134851765	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgggcctgacggagtgccgcGtctccatcagcagcctgtgg	15	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:134851765G>T	uc003eqt.2	+	5	1391	c.1171G>T	c.(1171-1173)GTC>TTC	p.V391F	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	391	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGAGTGCCGCGTCTCCATCAG	0.622													1	0	5.18039e-06	0.00308	5.51105e-06	7	39										T	134851765	G	T	134851765	3	4	63	1	0	0	0	0	1	0	0	0	5174	1145	40	4	1189	4	EPHB1	3	134851765	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	766638	134851765	63170665	108	18503										
PRR23A	729627	broad.mit.edu	37	chr3	138724624	138724624	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catctggagctccggaaactCggggtccgcgtcctcctcgt	12	15	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:138724624C>T	uc011bms.1	-	1	487	c.487G>A	c.(487-489)GAG>AAG	p.E163K		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	163											0						TCCGGAAACTCGGGGTCCGCG	0.657													0	0	0	0.009096	0	4	20										T	138724624	C	T	138724624	3	4	63	1	0	0	0	0	1	0	0	0	12594	893	31	1	317	1	PRR23A	3	138724624	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3872859	138724624	59297806	109	18504										
CPB1	1360	broad.mit.edu	37	chr3	148562481	148562481	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagagccgattttggagaaaGactcgctccacccatactgg	10	12	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:148562481G>C	uc003ewl.2	+	8	728	c.705G>C	c.(703-705)AAG>AAC	p.K235N		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	235					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGGAGAAAGACTCGCTCCA	0.438													0	0	0	0.004482	0	7	105										C	148562481	G	C	148562481	3	2	63	1	0	0	0	0	1	0	0	0	3796	933	33	1	735	1	CPB1	3	148562481	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	9837857	148562481	49459949	110	18505										
WWTR1	25937	broad.mit.edu	37	chr3	149245664	149245664	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctattattagtgatggatctCatgtctggggtcatcgtggg	13	6	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:149245664C>T	uc003exe.2	-	4	880	c.864G>A	c.(862-864)ATG>ATA	p.M288I	WWTR1_uc003exf.2_Missense_Mutation_p.M288I|WWTR1_uc011bns.1_Missense_Mutation_p.M288I|WWTR1_uc003exh.2_Missense_Mutation_p.M288I	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	288					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TGATGGATCTCATGTCTGGGG	0.463													0	0	0	0.003163	0	14	201										T	149245664	C	T	149245664	3	4	63	1	0	0	0	0	1	0	0	0	17414	826	29	1	350	1	WWTR1	3	149245664	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	683183	149245664	48776766	111	18506										
MED12L	116931	broad.mit.edu	37	chr3	150906195	150906195	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agtctatttcttcatcctctCttgctggatccagtttgcct	6	12	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:150906195C>T	uc003eyp.2	+	12	1719	c.1681C>T	c.(1681-1683)CTT>TTT	p.L561F	MED12L_uc011bnz.1_Missense_Mutation_p.L421F|MED12L_uc003eyn.2_Missense_Mutation_p.L561F|MED12L_uc003eyo.2_Missense_Mutation_p.L561F	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	561					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCATCCTCTCTTGCTGGATC	0.373													0	0	0	0.001984	0	5	66										T	150906195	C	T	150906195	3	4	63	1	0	0	0	0	1	0	0	0	9429	913	32	1	1727	1	MED12L	3	150906195	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1660531	150906195	47116235	112	18507										
RAP2B	5912	broad.mit.edu	37	chr3	152880590	152880590	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagaagtacgacccgaccatCgaagacttttaccgcaagga	10	11	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:152880590C>T	uc003ezr.2	+	1	562	c.108C>T	c.(106-108)ATC>ATT	p.I36I		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	36	Effector region (Probable).				Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			ACCCGACCATCGAAGACTTTT	0.627													0	0	0	0.008291	0	9	117										T	152880590	C	T	152880590	2	4	63	1	0	0	0	0	0	0	0	1	13041	874	31	1		1	RAP2B	3	152880590	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1974395	152880590	45141840	113	18508										
PTX3	5806	broad.mit.edu	37	chr3	157160451	157160451	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtgcggcacctggaattcaGaggaagggctcacatccttg	13	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:157160451G>A	uc003fbl.3	+	3	972	c.829G>A	c.(829-831)GAG>AAG	p.E277K	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	277	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTGGAATTCAGAGGAAGGGCT	0.537													0	0	0	0.009096	0	3	71										A	157160451	G	A	157160451	3	1	63	1	0	0	0	0	1	0	0	0	12822	943	33	1	839	1	PTX3	3	157160451	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4279861	157160451	40861979	114	18509										
SI	6476	broad.mit.edu	37	chr3	164724636	164724636	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttcatctgtgaccatccataGagattgtgaacatcgtaatg	8	8	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:164724636G>T	uc003fei.2	-	37	4436	c.4374C>A	c.(4372-4374)CTC>CTA	p.L1458L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1458	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACCATCCATAGAGATTGTGAA	0.348										HNSCC(35;0.089)			1	0	0.00116845	0.001168	0.00119841	5	58										T	164724636	G	T	164724636	2	4	63	1	0	0	0	0	0	0	0	1	14297	929	33	3		3	SI	3	164724636	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	7564185	164724636	33297794	115	18510										
BCHE	590	broad.mit.edu	37	chr3	165548711	165548711	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atccctctgacttttccattCtttgttgcaattatgatgtc	5	10	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:165548711C>G	uc003fem.3	-	2	271	c.111G>C	c.(109-111)AAG>AAC	p.K37N	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	37					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CTTTTCCATTCTTTGTTGCAA	0.408													0	0	0	0.000602	0	3	44										G	165548711	C	G	165548711	3	3	63	1	0	0	0	0	1	0	0	0	1358	912	32	1	1709	1	BCHE	3	165548711	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	824075	165548711	32473719	116	18511										
NAALADL2	254827	broad.mit.edu	37	chr3	174951896	174951896	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcagcagtggtcaatgctttCatcctaatggccagccttgc	10	12	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:174951896C>T	uc003fit.2	+	3	808	c.721C>T	c.(721-723)CAT>TAT	p.H241Y	NAALADL2_uc003fiu.1_Missense_Mutation_p.H234Y|NAALADL2_uc010hwy.1_Missense_Mutation_p.H63Y	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	241	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TCAATGCTTTCATCCTAATGG	0.488													0	0	0	0.00278	0	22	102										T	174951896	C	T	174951896	3	4	63	1	0	0	0	0	1	0	0	0	10130	826	29	1	731	1	NAALADL2	3	174951896	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	9403185	174951896	23070534	117	18512										
ZMAT3	64393	broad.mit.edu	37	chr3	178742989	178742989	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatcacgtggaattctctgcCgagagcggggattgaagtaa	14	7	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:178742989C>A	uc003fjg.2	-	6	945	c.686G>T	c.(685-687)CGG>CTG	p.R229L	ZMAT3_uc010hxa.2_Missense_Mutation_p.R228L|ZMAT3_uc003fji.2_Missense_Mutation_p.R228L	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	229					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			AATTCTCTGCCGAGAGCGGGG	0.418													1	0	0.00024832	0.009096	0.000257326	4	22										A	178742989	C	A	178742989	3	1	63	1	0	0	0	0	1	0	0	0	17690	652	23	4	187	4	ZMAT3	3	178742989	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3791093	178742989	19279441	118	18513										
PEX5L	51555	broad.mit.edu	37	chr3	179597763	179597763	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	actctgagaggctggcctctCtgctcagcatccgtgctgat	11	13	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:179597763C>T	uc003fki.1	-	5	589	c.459G>A	c.(457-459)CAG>CAA	p.Q153Q	PEX5L_uc011bqd.1_Silent_p.Q110Q|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Intron|PEX5L_uc003fkj.1_Silent_p.Q118Q|PEX5L_uc010hxd.1_Silent_p.Q151Q|PEX5L_uc011bqg.1_Silent_p.Q129Q|PEX5L_uc011bqh.1_Silent_p.Q94Q	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	153					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GCTGGCCTCTCTGCTCAGCAT	0.512													0	0	0	0.013537	0	9	72										T	179597763	C	T	179597763	2	4	63	1	0	0	0	0	0	0	0	1	11749	912	32	1		1	PEX5L	3	179597763	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	854774	179597763	18424667	119	18514										
B3GNT5	84002	broad.mit.edu	37	chr3	182987890	182987890	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaactgctcctgaaaactatGatcgacgttccggaattaga	8	9	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182987890G>A	uc003flk.2	+	2	834	c.304G>A	c.(304-306)GAT>AAT	p.D102N	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.D102N|B3GNT5_uc003flm.2_Missense_Mutation_p.D102N	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	102	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGAAAACTATGATCGACGTTC	0.438													0	0	0	0.000602	0	5	67										A	182987890	G	A	182987890	3	1	63	1	0	0	0	0	1	0	0	0	1260	1290	45	1	306	1	B3GNT5	3	182987890	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3390127	182987890	15034540	120	18515			1	83		4	4	699	G		2.728469e-07
B3GNT5	84002	broad.mit.edu	37	chr3	182988156	182988156	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccacatgccaaatttcttatGactgctgatgatgacatatt	6	9	1	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182988156G>C	uc003flk.2	+	2	1100	c.570G>C	c.(568-570)ATG>ATC	p.M190I	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.M190I|B3GNT5_uc003flm.2_Missense_Mutation_p.M190I	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	190	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AATTTCTTATGACTGCTGATG	0.353													0	0	0	0.013537	0	12	152										C	182988156	G	C	182988156	3	2	63	1	0	0	0	0	1	0	0	0	1260	1290	45	1	572	1	B3GNT5	3	182988156	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	266	182988156	15034274	121	18516			1	83		4	4	699	G		2.728469e-07
B3GNT5	84002	broad.mit.edu	37	chr3	182988310	182988310	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaaatactacgtgtcctatGaaatgtaccagtggccagct	9	10	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182988310G>A	uc003flk.2	+	2	1254	c.724G>A	c.(724-726)GAA>AAA	p.E242K	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.E242K|B3GNT5_uc003flm.2_Missense_Mutation_p.E242K	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	242	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CGTGTCCTATGAAATGTACCA	0.463													0	0	0	0.001168	0	5	88										A	182988310	G	A	182988310	3	1	63	1	0	0	0	0	1	0	0	0	1260	1291	45	1	726	1	B3GNT5	3	182988310	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	154	182988310	15034120	122	18517			1	83		4	4	699	G		2.728469e-07
B3GNT5	84002	broad.mit.edu	37	chr3	182988588	182988588	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatctccaggacctttggaaGaatgctacagatcctaaagt	9	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182988588G>C	uc003flk.2	+	2	1532	c.1002G>C	c.(1000-1002)AAG>AAC	p.K334N	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.K334N|B3GNT5_uc003flm.2_Missense_Mutation_p.K334N	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	334	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCTTTGGAAGAATGCTACAG	0.343													0	0	0	0.000602	0	4	33										C	182988588	G	C	182988588	3	2	63	1	0	0	0	0	1	0	0	0	1260	933	33	1	1004	1	B3GNT5	3	182988588	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	278	182988588	15033842	123	18518			1	83		4	4	699	G		2.728469e-07
AHSG	197	broad.mit.edu	37	chr3	186331033	186331033	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gacaaccgaactgcgatgatCcagaaactgaggaagcagct	11	10	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:186331033C>T	uc003fqk.3	+	1	184	c.103C>T	c.(103-105)CCA>TCA	p.P35S	AHSG_uc003fqj.2_Missense_Mutation_p.P35S|AHSG_uc003fql.3_Missense_Mutation_p.P35S|AHSG_uc003fqm.3_Missense_Mutation_p.P35S|AHSG_uc010hyp.2_Missense_Mutation_p.P35S	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	35	Cystatin fetuin-A-type 1.				acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		CTGCGATGATCCAGAAACTGA	0.502													0	0	0	0.001984	0	7	53										T	186331033	C	T	186331033	3	4	63	1	0	0	0	0	1	0	0	0	420	855	30	1	105	1	AHSG	3	186331033	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3342445	186331033	11691397	124	18519										
KIAA1530	57654	broad.mit.edu	37	chr4	1347046	1347046	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagtagagacctgcctgcctCtgcaggccaccccagagcgg	12	16	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:1347046C>T	uc003gde.3	+	5	1226	c.779C>T	c.(778-780)TCT>TTT	p.S260F		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	260											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CTGCCTGCCTCTGCAGGCCAC	0.706													0	0	0	0.004672	0	3	17										T	1347046	C	T	1347046	3	4	63	1	0	0	0	0	1	0	0	0	8241	913	32	1	793	1	KIAA1530	4	1347046	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		1347046	189807230	125	18520										
WHSC1	7468	broad.mit.edu	37	chr4	1957023	1957023	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgctcggaaggggaagcgacAccacgcccacgtcaacgtga	13	13	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:1957023A>C	uc003gdz.3	+	13	2650	c.2474A>C	c.(2473-2475)CAC>CCC	p.H825P	WHSC1_uc003geb.3_Missense_Mutation_p.H825P|WHSC1_uc003gec.3_Missense_Mutation_p.H825P|WHSC1_uc003ged.3_Missense_Mutation_p.H825P|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.H44P|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Missense_Mutation_p.H173P	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	825					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGGAAGCGACACCACGCCCAC	0.612			T	IGH@	MM								0	0	0	0.013537	0	10	40										C	1957023	A	C	1957023	3	2	63	1	0	0	0	0	1	0	0	0	17359	159	6	5	2596	5	WHSC1	4	1957023	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	609977	1957023	189197253	126	18521										
SEL1L3	23231	broad.mit.edu	37	chr4	25849234	25849234	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tatttgtgtcctgctggtgtGaagatgtttctcattcttcc	9	8	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:25849234G>A	uc003gru.3	-	2	567	c.415C>T	c.(415-417)CAC>TAC	p.H139Y		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	139						integral to membrane	binding				0						CTGCTGGTGTGAAGATGTTTC	0.388													0	0	0	0.001168	0	5	41										A	25849234	G	A	25849234	3	1	63	1	0	0	0	0	1	0	0	0	14012	1290	45	1	3075	1	SEL1L3	4	25849234	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	23892211	25849234	165305042	127	18522										
ARAP2	116984	broad.mit.edu	37	chr4	36212143	36212143	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttccacttgttgagcttaaCggataactgtgcctattaac	7	9	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:36212143C>G	uc003gsq.1	-	6	1694	c.1356G>C	c.(1354-1356)CCG>CCC	p.P452P	ARAP2_uc003gsr.1_Silent_p.P452P	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	452					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TTGAGCTTAACGGATAACTGT	0.383													0	0	0	0.006214	0	7	67										G	36212143	C	G	36212143	2	3	63	1	0	0	0	0	0	0	0	1	839	523	19	4		4	ARAP2	4	36212143	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	10362909	36212143	154942133	128	18523										
TBC1D1	23216	broad.mit.edu	37	chr4	38037247	38037247	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagcagcgagagaatgaattGattatttcttttctgagatg	11	4	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:38037247G>C	uc003gtb.2	+	8	1684	c.1341G>C	c.(1339-1341)TTG>TTC	p.L447F	TBC1D1_uc011byd.1_Missense_Mutation_p.L447F|TBC1D1_uc010ifd.2_Missense_Mutation_p.L194F|TBC1D1_uc011byf.1_Missense_Mutation_p.L318F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	447						nucleus	Rab GTPase activator activity			ovary(1)	1						AGAATGAATTGATTATTTCTT	0.333													0	0	0	0.006214	0	8	36										C	38037247	G	C	38037247	3	2	63	1	0	0	0	0	1	0	0	0	15594	1281	45	1	1367	1	TBC1D1	4	38037247	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1825104	38037247	153117029	129	18524										
WDR19	57728	broad.mit.edu	37	chr4	39254832	39254832	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agtgtaatccgcatctatctGgatcacctcaataatcctga	6	11	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:39254832G>C	uc003gtv.2	+	25	2950	c.2796G>C	c.(2794-2796)CTG>CTC	p.L932L	WDR19_uc011byi.1_Silent_p.L772L|WDR19_uc003gtw.1_Silent_p.L529L	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	932					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						GCATCTATCTGGATCACCTCA	0.348													0	0	0	0.006214	0	8	56										C	39254832	G	C	39254832	2	2	63	1	0	0	0	0	0	0	0	1	17276	1335	47	4		4	WDR19	4	39254832	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1217585	39254832	151899444	130	18525										
UBE2K	3093	broad.mit.edu	37	chr4	39779392	39779392	+	Frame_Shift_Del	DEL	A	A	-													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttctagtccagaatacaccAaaaaaatagaaaacctatgt							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:39779392delA	uc003guu.3	+	6	774	c.490delA	c.(490-492)AAAfs	p.K164fs	UBE2K_uc003gus.3_Intron|UBE2K_uc003gut.3_Frame_Shift_Del_p.K113fs|UBE2K_uc010ifn.2_RNA|UBE2K_uc011byq.1_Frame_Shift_Del_p.K103fs|UBE2K_uc003guq.3_Frame_Shift_Del_p.K61fs	NM_005339	NP_005330	P61086	UBE2K_HUMAN	ubiquitin-conjugating enzyme E2K isoform 1	164	UBA.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						AGAATACACCAAAAAAATAGA	0.363																		7	122	---	---								-	39779392	A	-	39779392	7	5	63	1	0	1	0	1	0	0	0	0	16859	131	5	0	512	0	UBE2K	4	39779392	Frame_Shift_Del	DEL	A	TCGA-DK-A3IU-01A-11D-A20D-08	524560	39779392	151374884	131	18526										
GABRA2	2555	broad.mit.edu	37	chr4	46390673	46390673	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctggcagggtcccacaccaaGaaaacaaaaagcaggaactg	10	11	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:46390673G>A	uc003gxc.3	-	1	724	c.51C>T	c.(49-51)TTC>TTT	p.F17F	GABRA2_uc010igc.2_Silent_p.F17F|GABRA2_uc011bzc.1_5'UTR|GABRA2_uc003gxe.2_Silent_p.F17F|GABRA2_uc010igd.1_Silent_p.F17F	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	17					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCCACACCAAGAAAACAAAAA	0.363													0	0	0	0.013537	0	9	120										A	46390673	G	A	46390673	2	1	63	1	0	0	0	0	0	0	0	1	6161	933	33	1		1	GABRA2	4	46390673	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	6611281	46390673	144763603	132	18527										
GABRA4	2557	broad.mit.edu	37	chr4	46973161	46973161	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatgaaacttgagaaagaatCactgtcataatgcacggaat	8	6	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:46973161C>T	uc003gxg.2	-	7	952	c.813G>A	c.(811-813)GTG>GTA	p.V271V		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	271	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAGAAAGAATCACTGTCATAA	0.363													0	0	0	0.004482	0	9	32										T	46973161	C	T	46973161	2	4	63	1	0	0	0	0	0	0	0	1	6163	813	29	1		1	GABRA4	4	46973161	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	582488	46973161	144181115	133	18528										
EPHA5	2044	broad.mit.edu	37	chr4	66280023	66280023	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cactggggtggtttcaaactCaaatcttcgactgaagacac	9	10	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:66280023C>T	uc003hcy.2	-	7	1859	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K	EPHA5_uc003hcx.2_Missense_Mutation_p.E487K|EPHA5_uc003hcz.2_Missense_Mutation_p.E556K|EPHA5_uc011cah.1_Missense_Mutation_p.E556K|EPHA5_uc011cai.1_Missense_Mutation_p.E556K|EPHA5_uc003hda.2_Missense_Mutation_p.E556K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	556	Extracellular (Potential).|Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTTTCAAACTCAAATCTTCGA	0.438										TSP Lung(17;0.13)			0	0	0	0.003163	0	9	74										T	66280023	C	T	66280023	3	4	63	1	0	0	0	0	1	0	0	0	5170	835	29	1	1495	1	EPHA5	4	66280023	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	19306862	66280023	124874253	134	18529										
YTHDC1	91746	broad.mit.edu	37	chr4	69188522	69188522	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acgtcctcgtgatcggggctGagaatgcattcttctcttgt	11	10	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:69188522G>A	uc003hdx.2	-	11	1899	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.Q498*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	516	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						GATCGGGGCTGAGAATGCATT	0.463													0	0	0	0.010729	0	12	69										A	69188522	G	A	69188522	4	1	63	1	0	0	0	0	0	1	0	0	17493	1299	45	1	665	1	YTHDC1	4	69188522	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2908499	69188522	121965754	135	18530										
UGT2B10	7365	broad.mit.edu	37	chr4	69874575	69874575	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaaaatattgttctactcacGaaggatcattaattactgtc	5	7	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:69874575G>T	uc011cao.1	-	8	1332	c.1196C>A	c.(1195-1197)TCA>TAA	p.S399*	UGT2B10_uc011can.1_Nonsense_Mutation_p.S315*			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	436					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTCTACTCACGAAGGATCATT	0.368													1	0	5.82388e-19	0.01441	6.43523e-19	45	105										T	69874575	G	T	69874575	4	4	63	1	0	0	0	0	0	1	0	0	16953	1072	37	3	1898	3	UGT2B10	4	69874575	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	686053	69874575	121279701	136	18531										
MUC7	4589	broad.mit.edu	37	chr4	71339777	71339777	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttgtgtgcatctgtgcactGagtgcttgcttctcggtaag	12	8	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:71339777G>A	uc011cat.1	+	3	327	c.39G>A	c.(37-39)CTG>CTA	p.L13L	MUC7_uc011cau.1_Silent_p.L13L|MUC7_uc003hfj.2_Silent_p.L13L	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	13						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			TCTGTGCACTGAGTGCTTGCT	0.373													0	0	0	0.010729	0	9	68										A	71339777	G	A	71339777	2	1	63	1	0	0	0	0	0	0	0	1	9981	1277	45	1		1	MUC7	4	71339777	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1465202	71339777	119814499	137	18532										
MUC7	4589	broad.mit.edu	37	chr4	71347324	71347324	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agctgccccacccacaccttCtgcaactacaccagctccac	4	21	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:71347324C>T	uc011cat.1	+	4	1151	c.863C>T	c.(862-864)TCT>TTT	p.S288F	MUC7_uc011cau.1_Missense_Mutation_p.S288F|MUC7_uc003hfj.2_Missense_Mutation_p.S288F|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	288	6.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CCCACACCTTCTGCAACTACA	0.577													0	0	0	0.004878	0	30	232										T	71347324	C	T	71347324	3	4	63	1	0	0	0	0	1	0	0	0	9981	913	32	1	869	1	MUC7	4	71347324	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	7547	71347324	119806952	138	18533										
GC	2638	broad.mit.edu	37	chr4	72623791	72623791	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaatcttcagaggcagactCacagcatttggagaggatgt	12	8	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:72623791C>T	uc003hge.2	-	7	952	c.799G>A	c.(799-801)GAG>AAG	p.E267K	GC_uc003hgd.2_Missense_Mutation_p.E145K|GC_uc010iie.2_Missense_Mutation_p.E267K|GC_uc010iif.2_Missense_Mutation_p.E286K	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	267	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GAGGCAGACTCACAGCATTTG	0.338													0	0	0	0.013537	0	13	77										T	72623791	C	T	72623791	3	4	63	1	0	0	0	0	1	0	0	0	6282	835	29	1	649	1	GC	4	72623791	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1276467	72623791	118530485	139	18534										
CDKL2	8999	broad.mit.edu	37	chr4	76523333	76523333	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccttctttctgttttgggaTtttttagataaagaaacatt	6	5	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:76523333T>A	uc003hiq.2	-	8	1473	c.948A>T	c.(946-948)AAA>AAT	p.K316N	CDKL2_uc011cbp.1_Missense_Mutation_p.K316N|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	316					sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TGTTTTGGGATTTTTTAGATA	0.274													0	0	0	0.00308	0	4	38										A	76523333	T	A	76523333	3	1	63	1	0	0	0	0	1	0	0	0	3154	1490	52	5	549	5	CDKL2	4	76523333	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	3899542	76523333	114630943	140	18535										
G3BP2	9908	broad.mit.edu	37	chr4	76572312	76572312	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcgaattattctacggttgtCagagtcattctgttccatat	8	8	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:76572312C>G	uc003hir.2	-	10	1123	c.958G>C	c.(958-960)GAC>CAC	p.D320H	G3BP2_uc003his.2_Missense_Mutation_p.D320H|G3BP2_uc003hit.2_Missense_Mutation_p.D287H	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	320					cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CTACGGTTGTCAGAGTCATTC	0.343													0	0	0	0.004007	0	12	105										G	76572312	C	G	76572312	3	3	63	1	0	0	0	0	1	0	0	0	6142	826	29	1	502	1	G3BP2	4	76572312	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	48979	76572312	114581964	141	18536										
SHROOM3	57619	broad.mit.edu	37	chr4	77691979	77691979	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtggtcaacctgctgctctcCctctcggggcgtctagcccg	12	16	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:77691979C>T	uc011cbx.1	+	10	6503	c.5550C>T	c.(5548-5550)TCC>TCT	p.S1850S	SHROOM3_uc003hkg.2_Silent_p.S1628S	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1850	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TGCTGCTCTCCCTCTCGGGGC	0.522													0	0	0	0.004656	0	24	103										T	77691979	C	T	77691979	2	4	63	1	0	0	0	0	0	0	0	1	14295	610	22	2		2	SHROOM3	4	77691979	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1119667	77691979	113462297	142	18537										
WDFY3	23001	broad.mit.edu	37	chr4	85638082	85638082	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctccttttatgaacttccttGatatcttcatatgcaaaaat	3	9	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:85638082G>C	uc003hpd.2	-	49	8250	c.7842C>G	c.(7840-7842)ATC>ATG	p.I2614M	WDFY3_uc003hpe.1_Missense_Mutation_p.I225M	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2614						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GAACTTCCTTGATATCTTCAT	0.368													0	0	0	0.004289	0	27	117										C	85638082	G	C	85638082	3	2	63	1	0	0	0	0	1	0	0	0	17267	1280	45	1	2818	1	WDFY3	4	85638082	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	7946103	85638082	105516194	143	18538										
MTTP	4547	broad.mit.edu	37	chr4	100530103	100530103	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatacatgctcgccattgttCaagacatcctacgttttgaa	6	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:100530103C>G	uc003hvc.3	+	13	1994	c.1738C>G	c.(1738-1740)CAA>GAA	p.Q580E	MTTP_uc011cej.1_Missense_Mutation_p.Q607E	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	580	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CGCCATTGTTCAAGACATCCT	0.403													0	0	0	0.003954	0	20	100										G	100530103	C	G	100530103	3	3	63	1	0	0	0	0	1	0	0	0	9964	827	29	1	1784	1	MTTP	4	100530103	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	14892021	100530103	90624173	144	18539										
CASP6	839	broad.mit.edu	37	chr4	110612078	110612078	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aacggaggctgcatccacctCagttatgttggtgtccaact	10	11	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:110612078C>T	uc003hzn.1	-	6	649	c.571G>A	c.(571-573)GAG>AAG	p.E191K	CASP6_uc003hzo.1_Missense_Mutation_p.E102K	NM_001226	NP_001217	P55212	CASP6_HUMAN	caspase 6 isoform alpha preproprotein	191					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		GCATCCACCTCAGTTATGTTG	0.468													0	0	0	0.006122	0	15	80										T	110612078	C	T	110612078	3	4	63	1	0	0	0	0	1	0	0	0	2675	835	29	1	318	1	CASP6	4	110612078	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	10081975	110612078	80542198	145	18540										
EGF	1950	broad.mit.edu	37	chr4	110864425	110864425	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcagagagtatgtaatataGagaaaaatgtttctggaatg	11	2	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:110864425G>C	uc003hzy.3	+	3	795	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	EGF_uc011cfu.1_Missense_Mutation_p.E115Q|EGF_uc011cfv.1_Missense_Mutation_p.E115Q	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	115	LDL-receptor class B 1.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATGTAATATAGAGAAAAATGT	0.249													0	0	0	0.00308	0	8	69										C	110864425	G	C	110864425	3	2	63	1	0	0	0	0	1	0	0	0	4962	943	33	1	353	1	EGF	4	110864425	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	252347	110864425	80289851	146	18541										
C4orf21	55345	broad.mit.edu	37	chr4	113524748	113524748	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtcataaagttttcatactCagtgctatctggaaactgac	7	8	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:113524748C>T	uc003iau.2	-	10	3119	c.2908G>A	c.(2908-2910)GAG>AAG	p.E970K	C4orf21_uc003iaw.2_Missense_Mutation_p.E970K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTTTCATACTCAGTGCTATCT	0.403													0	0	0	0.004007	0	12	72										T	113524748	C	T	113524748	3	4	63	1	0	0	0	0	1	0	0	0	2254	835	29	1	3482	1	C4orf21	4	113524748	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2660323	113524748	77629528	147	18542										
FAT4	79633	broad.mit.edu	37	chr4	126371442	126371442	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	accatacacctgaattctctCaaagccacatgagtgcaacc	5	14	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:126371442C>T	uc003ifj.3	+	9	9271	c.9271C>T	c.(9271-9273)CAA>TAA	p.Q3091*	FAT4_uc011cgp.1_Nonsense_Mutation_p.Q1389*|FAT4_uc003ifi.1_Nonsense_Mutation_p.Q569*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3091	Cadherin 30.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGAATTCTCTCAAAGCCACAT	0.458													0	0	0	0.004482	0	7	47										T	126371442	C	T	126371442	4	4	63	1	0	0	0	0	0	1	0	0	5692	827	29	1	9305	1	FAT4	4	126371442	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	12846694	126371442	64782834	148	18543										
HSPA4L	22824	broad.mit.edu	37	chr4	128722376	128722376	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttaaattgtttaaggttgatGaatgaaactactgcaggtga	10	3	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:128722376G>A	uc003ifm.2	+	5	766	c.513G>A	c.(511-513)ATG>ATA	p.M171I	HSPA4L_uc010iny.1_Missense_Mutation_p.M130I|HSPA4L_uc011cgr.1_Missense_Mutation_p.M138I	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	171					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TAAGGTTGATGAATGAAACTA	0.328													0	0	0	0.008291	0	8	34										A	128722376	G	A	128722376	3	1	63	1	0	0	0	0	1	0	0	0	7413	1290	45	1	531	1	HSPA4L	4	128722376	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2350934	128722376	62431900	149	18544										
DCHS2	54798	broad.mit.edu	37	chr4	155157962	155157962	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgaagcaacacaagataaccGacttgcttataaggatattc	7	8	0	2	rs138701263	byFrequency	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:155157962G>T	uc003inw.2	-	25	6477	c.6477C>A	c.(6475-6477)GTC>GTA	p.V2159V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2159	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CAAGATAACCGACTTGCTTAT	0.403													1	0	0.000442599	0.006214	0.000456288	8	53										T	155157962	G	T	155157962	2	4	63	1	0	0	0	0	0	0	0	1	4288	1045	37	3		3	DCHS2	4	155157962	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	26435586	155157962	35996314	150	18545										
IRF2	3660	broad.mit.edu	37	chr4	185340623	185340623	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccgcagggagttttagtacCtgtatggattgcccagtttc	12	9	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:185340623C>T	uc003iwf.3	-	3	387	c.187G>A	c.(187-189)GGA>AGA	p.G63R		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	63	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GTTTTAGTACCTGTATGGATT	0.433													0	0	0	0.003271	0	26	92										T	185340623	C	T	185340623	3	4	63	1	0	0	0	0	1	0	0	0	7828	695	24	2	890	2	IRF2	4	185340623	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	30182661	185340623	5813653	151	18546										
KIAA1430	57587	broad.mit.edu	37	chr4	186111383	186111383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggagtctaacactgaagacGactttgaggagacatcaggc	12	8	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:186111383G>A	uc003ixf.3	-	2	1115	c.968C>T	c.(967-969)TCG>TTG	p.S323L	KIAA1430_uc003ixg.2_Missense_Mutation_p.S323L	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	323											0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		CACTGAAGACGACTTTGAGGA	0.338													0	0	0	0.009096	0	4	25										A	186111383	G	A	186111383	3	1	63	1	0	0	0	0	1	0	0	0	8232	1059	37	1	646	1	KIAA1430	4	186111383	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	770760	186111383	5042893	152	18547										
SLC12A7	10723	broad.mit.edu	37	chr5	1076861	1076861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggcgatgaggatgccagtctCgcagatgaggactgtcagca	15	9	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:1076861C>T	uc003jbu.2	-	13	1762	c.1696G>A	c.(1696-1698)GAG>AAG	p.E566K		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	566	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ATGCCAGTCTCGCAGATGAGG	0.652													0	0	0	0.001984	0	6	77										T	1076861	C	T	1076861	3	4	63	1	0	0	0	0	1	0	0	0	14388	893	31	1	1603	1	SLC12A7	5	1076861	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		1076861	179838399	153	18548										
ADAMTS16	170690	broad.mit.edu	37	chr5	5239387	5239387	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccaagcaccaccacaccaacCgtgagtactttagagctgcc	7	16	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:5239387C>T	uc003jdl.2	+	15	2416	c.2278C>T	c.(2278-2280)CAG>TAG	p.Q760*	ADAMTS16_uc003jdk.1_Nonsense_Mutation_p.Q760*|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	760	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CCACACCAACCGTGAGTACTT	0.512													0	0	0	0.00499	0	16	120										T	5239387	C	T	5239387	4	4	63	1	0	0	0	0	0	1	0	0	261	666	23	2	2336	2	ADAMTS16	5	5239387	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4162526	5239387	175675873	154	18549										
ADAMTS16	170690	broad.mit.edu	37	chr5	5239993	5239993	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cggtcctataatgagcccgaGaacttaatcgctactggacc	9	12	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:5239993G>A	uc003jdl.2	+	16	2616	c.2478G>A	c.(2476-2478)GAG>GAA	p.E826E	ADAMTS16_uc003jdk.1_Silent_p.E826E	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	826	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATGAGCCCGAGAACTTAATCG	0.517													0	0	0	0.00308	0	7	138										A	5239993	G	A	5239993	2	1	63	1	0	0	0	0	0	0	0	1	261	933	33	1		1	ADAMTS16	5	5239993	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	606	5239993	175675267	155	18550										
DNAH5	1767	broad.mit.edu	37	chr5	13735275	13735275	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaaactcttcatgcttgactCggttcctctggatgtcaatc	8	11	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:13735275C>T	uc003jfd.2	-	68	11768	c.11726G>A	c.(11725-11727)CGA>CAA	p.R3909Q	DNAH5_uc003jfc.2_Missense_Mutation_p.R77Q	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3909					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGCTTGACTCGGTTCCTCTG	0.438									Kartagener_syndrome				0	0	0	0.010729	0	8	110										T	13735275	C	T	13735275	3	4	63	1	0	0	0	0	1	0	0	0	4604	884	31	1	2196	1	DNAH5	5	13735275	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	8495282	13735275	167179985	156	18551										
TRIO	7204	broad.mit.edu	37	chr5	14304625	14304625	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cggtgaggtagaccttccctCagagctgcaggacctagaag	13	11	1	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:14304625C>T	uc003jff.2	+	8	1430	c.1424C>T	c.(1423-1425)TCA>TTA	p.S475L	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.S426L|TRIO_uc003jfh.1_Missense_Mutation_p.S124L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	475					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GACCTTCCCTCAGAGCTGCAG	0.393													0	0	0	0.010729	0	10	186										T	14304625	C	T	14304625	3	4	63	1	0	0	0	0	1	0	0	0	16549	838	29	1	1454	1	TRIO	5	14304625	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	569350	14304625	166610635	157	18552										
NPR3	4883	broad.mit.edu	37	chr5	32712174	32712174	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggcttctgccgccgggcactCgcttccaggtggcttacgag	14	14	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:32712174C>T	uc003jhv.2	+	1	510	c.292C>T	c.(292-294)CGC>TGC	p.R98C	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.R98C	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	98	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GCCGGGCACTCGCTTCCAGGT	0.662													0	0	0	0.009096	0	3	46										T	32712174	C	T	32712174	3	4	63	1	0	0	0	0	1	0	0	0	10596	884	31	1	294	1	NPR3	5	32712174	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	18407549	32712174	148203086	158	18553										
BRIX1	55299	broad.mit.edu	37	chr5	34924954	34924954	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtttcctttttattaaagatCatagaagaagatgctgctct	7	6	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:34924954C>T	uc003jja.2	+	9	690	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_018321	NP_060791	Q8TDN6	BRX1_HUMAN	BRIX	222	Brix.				ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding				0						TATTAAAGATCATAGAAGAAG	0.323													0	0	0	0.009096	0	3	48										T	34924954	C	T	34924954	2	4	63	1	0	0	0	0	0	0	0	1	1515	816	29	1		1	BRIX1	5	34924954	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2212780	34924954	145990306	159	18554										
C5orf42	65250	broad.mit.edu	37	chr5	37180226	37180226	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttttagtattatgagtgatgGaaataatatcatcattgatt	7	2	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:37180226G>A	uc011cpa.1	-	28	5861	c.5630C>T	c.(5629-5631)TCC>TTC	p.S1877F	C5orf42_uc011coy.1_Missense_Mutation_p.S377F|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.S952F	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1877										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATGAGTGATGGAAATAATATC	0.284													0	0	0	0.004672	0	3	55										A	37180226	G	A	37180226	3	1	63	1	0	0	0	0	1	0	0	0	2301	1174	41	1	4063	1	C5orf42	5	37180226	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2255272	37180226	143735034	160	18555										
PARP8	79668	broad.mit.edu	37	chr5	49963917	49963917	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtttcagatttcagatactCtgactccacctttactttta	4	10	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:49963917C>T	uc003jon.3	+	3	286	c.104C>T	c.(103-105)TCT>TTT	p.S35F	PARP8_uc011cpz.1_5'UTR|PARP8_uc003joo.2_Missense_Mutation_p.S35F|PARP8_uc003jop.2_Missense_Mutation_p.S35F	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	35						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TTCAGATACTCTGACTCCACC	0.453													0	0	0	0.00308	0	6	86										T	49963917	C	T	49963917	3	4	63	1	0	0	0	0	1	0	0	0	11465	913	32	1	110	1	PARP8	5	49963917	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	12783691	49963917	130951343	161	18556										
ITGA2	3673	broad.mit.edu	37	chr5	52355784	52355784	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acatctcatggccatttgatCtttcctaaacaagcctttga	5	11	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:52355784C>T	uc003joy.2	+	11	1397	c.1254C>T	c.(1252-1254)ATC>ATT	p.I418I	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.I342I|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	418	Extracellular (Potential).|FG-GAP 3.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GCCATTTGATCTTTCCTAAAC	0.408													0	0	0	0.009096	0	4	41										T	52355784	C	T	52355784	2	4	63	1	0	0	0	0	0	0	0	1	7875	903	32	1		1	ITGA2	5	52355784	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2391867	52355784	128559476	162	18557										
HTR1A	3350	broad.mit.edu	37	chr5	63257013	63257013	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcggggtccgagcggtcttcCggggtgcgccagcccagcat	16	14	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:63257013C>A	uc011cqt.1	-	1	534	c.534G>T	c.(532-534)CCG>CCT	p.P178P		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	178	Helical; Name=4; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGCGGTCTTCCGGGGTGCGCC	0.597													1	0	2.51541e-25	0.004878	2.78973e-25	29	143										A	63257013	C	A	63257013	2	1	63	1	0	0	0	0	0	0	0	1	7436	639	23	4		4	HTR1A	5	63257013	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	10901229	63257013	117658247	163	18558										
VCAN	1462	broad.mit.edu	37	chr5	82833887	82833887	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttgaggttcctgcaaccaccAtttatccagtttctgaacaa	6	11	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:82833887A>G	uc003kii.3	+	8	5421	c.5065A>G	c.(5065-5067)ATT>GTT	p.I1689V	VCAN_uc003kij.3_Missense_Mutation_p.I702V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.I353V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1689	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGCAACCACCATTTATCCAGT	0.398													0	0	0	0.006122	0	14	72										G	82833887	A	G	82833887	3	3	63	1	0	0	0	0	1	0	0	0	17135	217	8	5	5091	5	VCAN	5	82833887	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	19576874	82833887	98081373	164	18559										
VCAN	1462	broad.mit.edu	37	chr5	82835572	82835572	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	attcaagagtcagatactgaGctcttattctctggactggg	10	8	4	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:82835572G>A	uc003kii.3	+	8	7106	c.6750G>A	c.(6748-6750)GAG>GAA	p.E2250E	VCAN_uc003kij.3_Silent_p.E1263E|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.E914E	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2250	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGATACTGAGCTCTTATTCT	0.378													0	0	0	0.00499	0	15	44										A	82835572	G	A	82835572	2	1	63	1	0	0	0	0	0	0	0	1	17135	962	34	2		2	VCAN	5	82835572	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1685	82835572	98079688	165	18560										
GPR98	84059	broad.mit.edu	37	chr5	90149230	90149230	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgaattccagagaggctactGgatgtccaggatgcagaaat	12	8	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:90149230G>A	uc003kju.2	+	80	17430	c.17334G>A	c.(17332-17334)CTG>CTA	p.L5778L	GPR98_uc003kjt.2_Silent_p.L3484L|GPR98_uc003kjw.2_Silent_p.L1439L	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5778	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAGGCTACTGGATGTCCAGG	0.398													0	0	0	0.009096	0	4	24										A	90149230	G	A	90149230	2	1	63	1	0	0	0	0	0	0	0	1	6721	1335	47	2		2	GPR98	5	90149230	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	7313658	90149230	90766030	166	18561										
WDR36	134430	broad.mit.edu	37	chr5	110440423	110440423	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tatttgatggtcctacaggtGaaggccgacttttgagattc	11	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:110440423G>A	uc003kpd.2	+	9	1219	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	368	WD 4.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TCCTACAGGTGAAGGCCGACT	0.418													0	0	0	0.006214	0	9	113										A	110440423	G	A	110440423	3	1	63	1	0	0	0	0	1	0	0	0	17287	1291	45	1	1136	1	WDR36	5	110440423	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	20291193	110440423	70474837	167	18562										
APC	324	broad.mit.edu	37	chr5	112178932	112178932	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcaataggtcaggaacctgGaaacgtgagcacagcaaaca	10	9	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:112178932G>A	uc010jby.2	+	16	8021	c.7641G>A	c.(7639-7641)TGG>TGA	p.W2547*	APC_uc011cvt.1_Nonsense_Mutation_p.W2529*|APC_uc003kpz.3_Nonsense_Mutation_p.W2547*|APC_uc003kpy.3_Nonsense_Mutation_p.W2547*|APC_uc010jbz.2_Nonsense_Mutation_p.W2264*|APC_uc010jca.2_Nonsense_Mutation_p.W1847*	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2547	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CAGGAACCTGGAAACGTGAGC	0.428		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			0	0	0	0.001168	0	5	56										A	112178932	G	A	112178932	4	1	63	1	0	0	0	0	0	1	0	0	763	1183	41	1	7699	1	APC	5	112178932	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1738509	112178932	68736328	168	18563										
FBN2	2201	broad.mit.edu	37	chr5	127704904	127704904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttgcagggcatggctggcagGgttctccaaaaccatagtct	12	10	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:127704904G>A	uc003kuu.2	-	16	2658	c.2219C>T	c.(2218-2220)CCC>CTC	p.P740L	FBN2_uc003kuv.2_Missense_Mutation_p.P707L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	740	TB 3.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGGCTGGCAGGGTTCTCCAAA	0.463													0	0	0	0.00278	0	20	67										A	127704904	G	A	127704904	3	1	63	1	0	0	0	0	1	0	0	0	5703	1232	43	2	6719	2	FBN2	5	127704904	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	15525972	127704904	53210356	169	18564										
KIF3A	11127	broad.mit.edu	37	chr5	132046656	132046656	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctaaacagaacttaccccttCtttttttccttttctctcca	1	14	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:132046656C>T	uc003kxo.2	-	9	1377	c.1223G>A	c.(1222-1224)AGA>AAA	p.R408K	KIF3A_uc003kxn.2_Missense_Mutation_p.R366K|KIF3A_uc011cxf.1_Missense_Mutation_p.R408K|KIF3A_uc003kxp.2_Missense_Mutation_p.R408K	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	408	Potential.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTACCCCTTCTTTTTTTCCT	0.388													0	0	0	0.00308	0	4	112										T	132046656	C	T	132046656	3	4	63	1	0	0	0	0	1	0	0	0	8300	913	32	1	912	1	KIF3A	5	132046656	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4341752	132046656	48868604	170	18565										
KIF3A	11127	broad.mit.edu	37	chr5	132052130	132052130	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagtttttgcctgtctttctGaaccctagcaataaacagag	7	10	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:132052130G>A	uc003kxo.2	-	7	915	c.761C>T	c.(760-762)TCA>TTA	p.S254L	KIF3A_uc003kxn.2_Missense_Mutation_p.S213L|KIF3A_uc011cxf.1_Missense_Mutation_p.S254L|KIF3A_uc003kxp.2_Missense_Mutation_p.S254L	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	254	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGTCTTTCTGAACCCTAGCA	0.328													0	0	0	0.001984	0	4	58										A	132052130	G	A	132052130	3	1	63	1	0	0	0	0	1	0	0	0	8300	1294	45	1	1382	1	KIF3A	5	132052130	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5474	132052130	48863130	171	18566										
PCDHB2	56133	broad.mit.edu	37	chr5	140475294	140475294	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggagaactgcttttaagacAgaaactggatttcgaatcca	10	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140475294A>G	uc003lil.2	+	1	1058	c.920A>G	c.(919-921)CAG>CGG	p.Q307R	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	307	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTTAAGACAGAAACTGGAT	0.413													0	0	0	0.006214	0	7	66										G	140475294	A	G	140475294	3	3	63	1	0	0	0	0	1	0	0	0	11542	188	7	5	922	5	PCDHB2	5	140475294	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	8423164	140475294	40439966	172	18567										
PCDHGA2	56113	broad.mit.edu	37	chr5	140719425	140719425	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agaggtatttgagcttaagtCaacatctggagaactgacaa	10	6	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140719425C>T	uc003ljk.1	+	1	1072	c.887C>T	c.(886-888)TCA>TTA	p.S296L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.S296L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	296	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTTAAGTCAACATCTGGA	0.443													0	0	0	0.006122	0	15	155										T	140719425	C	T	140719425	3	4	63	1	0	0	0	0	1	0	0	0	11554	838	29	1	889	1	PCDHGA2	5	140719425	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	244131	140719425	40195835	173	18568			2	84		3	3	622	N	G_C	5.498224e-05
PCDHGA2	56113	broad.mit.edu	37	chr5	140719466	140719466	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcataaaagatctagattatGaggatgctacattccatgaa	7	6	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140719466G>A	uc003ljk.1	+	1	1113	c.928G>A	c.(928-930)GAG>AAG	p.E310K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E310K	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	310	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTAGATTATGAGGATGCTAC	0.413													0	0	0	0.00499	0	13	176										A	140719466	G	A	140719466	3	1	63	1	0	0	0	0	1	0	0	0	11554	1291	45	1	930	1	PCDHGA2	5	140719466	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	41	140719466	40195794	174	18569			2	84		3	3	622	N	G_C	5.498224e-05
PCDHGA2	56113	broad.mit.edu	37	chr5	140720046	140720046	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcagggggcacccttatcctCttacatctctatcaactccg	6	15	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140720046C>G	uc003ljk.1	+	1	1693	c.1508C>G	c.(1507-1509)TCT>TGT	p.S503C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.S503C	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	503	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTTATCCTCTTACATCTCT	0.522													0	0	0	0.001168	0	6	57										G	140720046	C	G	140720046	3	3	63	1	0	0	0	0	1	0	0	0	11554	913	32	1	1510	1	PCDHGA2	5	140720046	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	580	140720046	40195214	175	18570			2	84		3	3	622	N	G_C	5.498224e-05
ARAP3	64411	broad.mit.edu	37	chr5	141044642	141044642	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagccggccctctccttgcaGatacagggtcctgagacccc	10	17	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:141044642G>A	uc003llm.2	-	19	2725	c.2647C>T	c.(2647-2649)CTG>TTG	p.L883L	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Silent_p.L545L|ARAP3_uc003lln.2_Silent_p.L785L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	883					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TCTCCTTGCAGATACAGGGTC	0.667											OREG0016871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	17										A	141044642	G	A	141044642	2	1	63	1	0	0	0	0	0	0	0	1	840	933	33	1		1	ARAP3	5	141044642	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	324596	141044642	39870618	176	18571										
TIGD6	81789	broad.mit.edu	37	chr5	149375650	149375650	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatgtttttggcatggatttCttgaaaccaagcaaaaacag	8	6	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:149375650C>A	uc003lri.2	-	2	1024	c.262G>T	c.(262-264)GAA>TAA	p.E88*	TIGD6_uc003lrj.2_Nonsense_Mutation_p.E88*	NM_030953	NP_112215	Q17RP2	TIGD6_HUMAN	hypothetical protein LOC81789	88	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GCATGGATTTCTTGAAACCAA	0.443													1	0	1.62565e-12	0.012213	1.78643e-12	28	207										A	149375650	C	A	149375650	4	1	63	1	0	0	0	0	0	1	0	0	15897	922	32	3	1307	3	TIGD6	5	149375650	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	8331008	149375650	31539610	177	18572										
ATP10B	23120	broad.mit.edu	37	chr5	160047939	160047939	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggacgtccccagagccttgcTtgagggtttgatggtgacct	14	10	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:160047939T>C	uc003lym.1	-	15	2678	c.1831A>G	c.(1831-1833)AGC>GGC	p.S611G	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.2_Missense_Mutation_p.S169G	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	611	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGCCTTGCTTGAGGGTTTG	0.463													0	0	0	0.004656	0	21	218										C	160047939	T	C	160047939	3	2	63	1	0	0	0	0	1	0	0	0	1117	1609	56	5	2602	5	ATP10B	5	160047939	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	10672289	160047939	20867321	178	18573										
ADAMTS2	9509	broad.mit.edu	37	chr5	178555036	178555036	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acagagtcctcttccaggacGttgttgtcgtcgacattcag	10	11	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:178555036G>T	uc003mjw.2	-	17	2541	c.2541C>A	c.(2539-2541)AAC>AAA	p.N847K		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	847	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTTCCAGGACGTTGTTGTCGT	0.587													1	0	6.72482e-11	0.003163	7.34953e-11	12	93										T	178555036	G	T	178555036	3	4	63	1	0	0	0	0	1	0	0	0	265	1136	40	4	1118	4	ADAMTS2	5	178555036	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	18507097	178555036	2360224	179	18574										
MAPK9	5601	broad.mit.edu	37	chr5	179675973	179675973	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccagccccggctatactcacCgttctctttgtagcccatac	6	17	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:179675973C>T	uc003mls.3	-	6	887	c.616G>A	c.(616-618)GTT>ATT	p.V206I	MAPK9_uc003mlt.3_Missense_Mutation_p.V206I|MAPK9_uc010jlc.2_Missense_Mutation_p.V206M|MAPK9_uc003mlv.3_Missense_Mutation_p.V206M|MAPK9_uc011dgx.1_Missense_Mutation_p.V206I	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	206	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTATACTCACCGTTCTCTTTG	0.512													0	0	0	0.01441	0	34	436										T	179675973	C	T	179675973	3	4	63	1	0	0	0	0	1	0	0	0	9287	666	23	2	808	2	MAPK9	5	179675973	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1120937	179675973	1239287	180	18575										
FLT4	2324	broad.mit.edu	37	chr5	180048704	180048704	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctcctccaggctggcggccaGaggggtggcgaacagatgca	16	12	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:180048704G>A	uc003mma.3	-	13	1937	c.1858C>T	c.(1858-1860)CTG>TTG	p.L620L	FLT4_uc003mlz.3_Silent_p.L620L|FLT4_uc003mmb.1_Silent_p.L153L|FLT4_uc011dgy.1_Silent_p.L620L	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	620	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGGCGGCCAGAGGGGTGGCG	0.682									Congenital_Hereditary_Lymphedema				0	0	0	0.009096	0	4	23										A	180048704	G	A	180048704	2	1	63	1	0	0	0	0	0	0	0	1	5944	933	33	1		1	FLT4	5	180048704	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	372731	180048704	866556	181	18576										
BTNL9	153579	broad.mit.edu	37	chr5	180475178	180475178	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcagcgtggtcctgcagcttCacagcatcatcccctctgac	9	16	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:180475178C>T	uc003mmt.2	+	3	592	c.361C>T	c.(361-363)CAC>TAC	p.H121Y	BTNL9_uc011dhi.1_Missense_Mutation_p.H52Y	NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	121	Extracellular (Potential).|Ig-like V-type.					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTGCAGCTTCACAGCATCAT	0.607													0	0	0	0.000602	0	5	32										T	180475178	C	T	180475178	3	4	63	1	0	0	0	0	1	0	0	0	1568	826	29	1	367	1	BTNL9	5	180475178	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	426474	180475178	440082	182	18577										
WRNIP1	56897	broad.mit.edu	37	chr6	2769089	2769089	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	accatcctttttattgatgaGattcatcggttcaataaatc	5	8	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:2769089G>A	uc003mtz.2	+	2	1178	c.987G>A	c.(985-987)GAG>GAA	p.E329E	WRNIP1_uc003mua.2_Silent_p.E329E	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	329					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				TTATTGATGAGATTCATCGGT	0.229													0	0	0	0.001984	0	5	30										A	2769089	G	A	2769089	2	1	63	1	0	0	0	0	0	0	0	1	17400	933	33	1		1	WRNIP1	6	2769089	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		2769089	168345978	183	18578										
RREB1	6239	broad.mit.edu	37	chr6	7229455	7229455	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcctgcagcacaccaaagacGtcaggcctgcccccgccgag	11	18	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:7229455G>C	uc003mxc.2	+	10	1513	c.1123G>C	c.(1123-1125)GTC>CTC	p.V375L	RREB1_uc003mxb.2_Missense_Mutation_p.V375L|RREB1_uc010jnx.2_Missense_Mutation_p.V375L	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	375					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CACCAAAGACGTCAGGCCTGC	0.642													0	0	0	0.009096	0	3	60										C	7229455	G	C	7229455	3	2	63	1	0	0	0	0	1	0	0	0	13679	1145	40	4	1149	4	RREB1	6	7229455	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4460366	7229455	163885612	184	18579										
TXNDC5	81567	broad.mit.edu	37	chr6	7899902	7899902	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acagcttcttggcctggcttGaaaagctttaagctgaaaga	10	8	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:7899902G>A	uc003mxv.2	-	3	458	c.426C>T	c.(424-426)TTC>TTT	p.F142F	TXNDC5_uc003mxw.2_Silent_p.F99F|TXNDC5_uc010jnz.2_Silent_p.F34F|TXNDC5_uc010joa.1_Silent_p.F34F	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	142	Thioredoxin 1.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					GGCCTGGCTTGAAAAGCTTTA	0.438													0	0	0	0.008291	0	9	59										A	7899902	G	A	7899902	2	1	63	1	0	0	0	0	0	0	0	1	16796	1281	45	1		1	TXNDC5	6	7899902	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	670447	7899902	163215165	185	18580										
HIVEP1	3096	broad.mit.edu	37	chr6	12123010	12123010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccaaaaacaaaggtagccatGagagaacctgagcacagccc	9	12	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:12123010G>A	uc003nac.2	+	4	3161	c.2982G>A	c.(2980-2982)ATG>ATA	p.M994I	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	994					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGTAGCCATGAGAGAACCTG	0.473													0	0	0	0.008291	0	9	256										A	12123010	G	A	12123010	3	1	63	1	0	0	0	0	1	0	0	0	7186	1290	45	1	2992	1	HIVEP1	6	12123010	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4223108	12123010	158992057	186	18581										
DHX16	8449	broad.mit.edu	37	chr6	30627933	30627933	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccaccaggaccttgagctcaGgtcggaagcgagcaacatcc	11	14	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:30627933G>A	uc003nqz.2	-	10	1843	c.1631C>T	c.(1630-1632)CCT>CTT	p.P544L	DHX16_uc003nqy.2_Missense_Mutation_p.P63L|DHX16_uc011dmo.1_Missense_Mutation_p.P484L	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	544	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CTTGAGCTCAGGTCGGAAGCG	0.537													0	0	0	0.001168	0	5	59										A	30627933	G	A	30627933	3	1	63	1	0	0	0	0	1	0	0	0	4502	1000	35	2	1538	2	DHX16	6	30627933	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	18504923	30627933	140487134	187	18582										
COL11A2	1302	broad.mit.edu	37	chr6	33146477	33146477	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctatggcccttctctccaggGagccctgggagtccatcaaa	10	14	2	0	rs139350991		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:33146477G>A	uc003ocx.1	-	18	1926	c.1698C>T	c.(1696-1698)CTC>CTT	p.L566L	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Silent_p.L480L|COL11A2_uc003ocz.1_Silent_p.L459L	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	566	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCTCTCCAGGGAGCCCTGGGA	0.562													0	0	0	0.013537	0	10	194										A	33146477	G	A	33146477	2	1	63	1	0	0	0	0	0	0	0	1	3668	1161	41	1		1	COL11A2	6	33146477	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2518544	33146477	137968590	188	18583										
YIPF3	25844	broad.mit.edu	37	chr6	43481144	43481144	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggagtaggatagcaaccaGagtgaagaccagcatgagag	14	6	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:43481144G>C	uc003ovl.1	-	5	644	c.487C>G	c.(487-489)CTG>GTG	p.L163V	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Missense_Mutation_p.L128V|YIPF3_uc010jyr.1_Missense_Mutation_p.L169V|YIPF3_uc010jys.1_Missense_Mutation_p.L6V|YIPF3_uc003ovm.1_Missense_Mutation_p.L37V|YIPF3_uc010jyt.1_Missense_Mutation_p.L112V	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	163	Helical; (Potential).				cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			ATAGCAACCAGAGTGAAGACC	0.473													0	0	0	0.00308	0	7	43										C	43481144	G	C	43481144	3	2	63	1	0	0	0	0	1	0	0	0	17476	933	33	1	585	1	YIPF3	6	43481144	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	10334667	43481144	127633923	189	18584										
HMGCLL1	54511	broad.mit.edu	37	chr6	55360227	55360227	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacaaaatacctgaagggccGtaaggatatttgctaaggct	10	7	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:55360227G>A	uc003pcn.2	-	8	1034	c.875C>T	c.(874-876)ACG>ATG	p.T292M	HMGCLL1_uc003pco.2_Missense_Mutation_p.T262M|HMGCLL1_uc010jzx.2_Missense_Mutation_p.T163M|HMGCLL1_uc011dxc.1_Missense_Mutation_p.T230M|HMGCLL1_uc011dxd.1_Missense_Mutation_p.T159M|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	292							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGAAGGGCCGTAAGGATATT	0.383													0	0	0	0.008291	0	8	67										A	55360227	G	A	55360227	3	1	63	1	0	0	0	0	1	0	0	0	7230	1145	40	2	249	2	HMGCLL1	6	55360227	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	11879083	55360227	115754840	190	18585										
DST	667	broad.mit.edu	37	chr6	56334713	56334713	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcaccaatctgctcaacttGaaatcgctttgcacatttac	4	12	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:56334713G>A	uc003pdf.2	-	91	16190	c.16162C>T	c.(16162-16164)CAA>TAA	p.Q5388*	DST_uc003pcz.3_Nonsense_Mutation_p.Q5210*|DST_uc011dxj.1_Nonsense_Mutation_p.Q5239*|DST_uc011dxk.1_Nonsense_Mutation_p.Q5250*|DST_uc003pcy.3_Nonsense_Mutation_p.Q4884*|DST_uc003pcw.3_5'Flank|DST_uc003pcx.3_5'UTR	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7296	GAR.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGCTCAACTTGAAATCGCTTT	0.313													0	0	0	0.00499	0	11	87										A	56334713	G	A	56334713	4	1	63	1	0	0	0	0	0	1	0	0	4783	1299	45	1	893	1	DST	6	56334713	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	974486	56334713	114780354	191	18586										
KCNQ5	56479	broad.mit.edu	37	chr6	73787121	73787121	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atttttgccacgtctgcactCagaagtctccgtttcctaca	6	13	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:73787121C>G	uc003pgk.2	+	4	1040	c.693C>G	c.(691-693)CTC>CTG	p.L231L	KCNQ5_uc003pgj.3_Silent_p.L231L|KCNQ5_uc011dyh.1_Silent_p.L231L|KCNQ5_uc011dyi.1_Silent_p.L231L|KCNQ5_uc010kat.2_Silent_p.L231L|KCNQ5_uc011dyj.1_Silent_p.L231L|KCNQ5_uc011dyk.1_5'UTR	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	231	Helical; Voltage-sensor; Name=Segment S4; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CGTCTGCACTCAGAAGTCTCC	0.463													0	0	0	0.004482	0	7	61										G	73787121	C	G	73787121	2	3	63	1	0	0	0	0	0	0	0	1	8086	813	29	1		1	KCNQ5	6	73787121	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	17452408	73787121	97327946	192	18587										
C6orf167	253714	broad.mit.edu	37	chr6	97613184	97613184	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggaatagtggctgtgtttctCaatgccagcaaaacaggatg	12	7	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:97613184C>T	uc003ppb.2	-	21	3425	c.3159G>A	c.(3157-3159)TTG>TTA	p.L1053L	C6orf167_uc011eaf.1_Silent_p.L1013L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1053					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CTGTGTTTCTCAATGCCAGCA	0.363													0	0	0	0.00278	0	18	97										T	97613184	C	T	97613184	2	4	63	1	0	0	0	0	0	0	0	1	2342	825	29	1		1	C6orf167	6	97613184	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	23826063	97613184	73501883	193	18588										
REV3L	5980	broad.mit.edu	37	chr6	111702567	111702567	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagtctttgggtcaaaggctGaaaagtctgactattttcca	9	8	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:111702567G>A	uc003puy.3	-	10	1500	c.1177C>T	c.(1177-1179)CAG>TAG	p.Q393*	REV3L_uc003pux.3_Nonsense_Mutation_p.Q315*|REV3L_uc003puz.3_Nonsense_Mutation_p.Q315*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	393					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTCAAAGGCTGAAAAGTCTGA	0.343								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.000602	0	5	75										A	111702567	G	A	111702567	4	1	63	1	0	0	0	0	0	1	0	0	13240	1299	45	1	8307	1	REV3L	6	111702567	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	14089383	111702567	59412500	194	18589										
LAMA4	3910	broad.mit.edu	37	chr6	112512903	112512903	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgcaacgttcacacttgaatCcggtggtgttgcgtaagcaa	11	10	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:112512903C>G	uc003pvu.2	-	6	962	c.653G>C	c.(652-654)GGA>GCA	p.G218A	LAMA4_uc003pvv.2_Missense_Mutation_p.G218A|LAMA4_uc003pvt.2_Missense_Mutation_p.G218A	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	218	Laminin EGF-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ACACTTGAATCCGGTGGTGTT	0.488													0	0	0	0.009096	0	4	51										G	112512903	C	G	112512903	3	3	63	1	0	0	0	0	1	0	0	0	8608	855	30	1	4954	1	LAMA4	6	112512903	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	810336	112512903	58602164	195	18590										
GPRC6A	222545	broad.mit.edu	37	chr6	117128367	117128367	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctgcagttgattcataaccCacctggaaatagacagaata	7	9	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:117128367C>T	uc003pxj.1	-	3	523	c.501G>A	c.(499-501)GTG>GTA	p.V167V	GPRC6A_uc003pxk.1_Silent_p.V167V|GPRC6A_uc003pxl.1_Silent_p.V167V	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	167	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTCATAACCCACCTGGAAAT	0.383													0	0	0	0.001984	0	5	80										T	117128367	C	T	117128367	2	4	63	1	0	0	0	0	0	0	0	1	6728	581	21	2		2	GPRC6A	6	117128367	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4615464	117128367	53986700	196	18591										
PTPRK	5796	broad.mit.edu	37	chr6	128326289	128326289	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagaggatcttctgcatgcaGagtgctctgatcagcataac	10	9	4	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:128326289G>C	uc003qbk.2	-	15	2798	c.2431C>G	c.(2431-2433)CTG>GTG	p.L811V	PTPRK_uc003qbj.2_Missense_Mutation_p.L812V|PTPRK_uc010kfc.2_Missense_Mutation_p.L812V|PTPRK_uc011ebu.1_Missense_Mutation_p.L812V|PTPRK_uc003qbl.1_Missense_Mutation_p.L706V|PTPRK_uc011ebv.1_Missense_Mutation_p.L822V|PTPRK_uc010kfd.1_Missense_Mutation_p.L25V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	811	Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCTGCATGCAGAGTGCTCTGA	0.393													0	0	0	0.00308	0	7	54										C	128326289	G	C	128326289	3	2	63	1	0	0	0	0	1	0	0	0	12805	933	33	1	1974	1	PTPRK	6	128326289	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	11197922	128326289	42788778	197	18592										
SAMD3	154075	broad.mit.edu	37	chr6	130505642	130505642	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aactcaatgatccttatcctCatgctgtgatccgggcactt	7	12	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:130505642C>A	uc003qbv.2	-	7	836	c.510G>T	c.(508-510)ATG>ATT	p.M170I	SAMD3_uc003qbx.2_Missense_Mutation_p.M170I|SAMD3_uc003qbw.2_Missense_Mutation_p.M170I|SAMD3_uc010kfg.1_Missense_Mutation_p.M170I|SAMD3_uc003qby.2_Missense_Mutation_p.M170I|SAMD3_uc003qbz.1_Missense_Mutation_p.M129I	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	170										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TCCTTATCCTCATGCTGTGAT	0.468													1	0	0.000274275	0.004482	0.000283733	8	54										A	130505642	C	A	130505642	3	1	63	1	0	0	0	0	1	0	0	0	13820	826	29	3	1096	3	SAMD3	6	130505642	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2179353	130505642	40609425	198	18593										
SAMD3	154075	broad.mit.edu	37	chr6	130505656	130505656	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tatcctcatgctgtgatccgGgcacttctgctctgctaaca	8	13	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:130505656G>T	uc003qbv.2	-	7	822	c.496C>A	c.(496-498)CCG>ACG	p.P166T	SAMD3_uc003qbx.2_Missense_Mutation_p.P166T|SAMD3_uc003qbw.2_Missense_Mutation_p.P166T|SAMD3_uc010kfg.1_Missense_Mutation_p.P166T|SAMD3_uc003qby.2_Missense_Mutation_p.P166T|SAMD3_uc003qbz.1_Missense_Mutation_p.P125T	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	166										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CTGTGATCCGGGCACTTCTGC	0.453													1	0	1.23904e-05	0.000602	1.30654e-05	5	57										T	130505656	G	T	130505656	3	4	63	1	0	0	0	0	1	0	0	0	13820	1232	43	4	1110	4	SAMD3	6	130505656	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	14	130505656	40609411	199	18594										
ENPP1	5167	broad.mit.edu	37	chr6	132201159	132201159	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atgcccctttggacatcctaTaccgtggacagaaatgcaag	9	11	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:132201159T>C	uc011ecf.1	+	20	2105	c.2085T>C	c.(2083-2085)TAT>TAC	p.Y695Y		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	695	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	GGACATCCTATACCGTGGACA	0.403													0	0	0	0.01441	0	42	192										C	132201159	T	C	132201159	2	2	63	1	0	0	0	0	0	0	0	1	5129	1413	49	5		5	ENPP1	6	132201159	Silent	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	1695503	132201159	38913908	200	18595										
PEX7	5191	broad.mit.edu	37	chr6	137167279	137167279	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agtattatttatagcacaatCtggtctccccacatccctgg	6	12	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:137167279C>G	uc003qhd.2	+	5	588	c.486C>G	c.(484-486)ATC>ATG	p.I162M	PEX7_uc010kgx.2_RNA	NM_000288	NP_000279	O00628	PEX7_HUMAN	peroxisomal biogenesis factor 7	162	WD 3.				ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		ATAGCACAATCTGGTCTCCCC	0.388													0	0	0	0.001984	0	5	64										G	137167279	C	G	137167279	3	3	63	1	0	0	0	0	1	0	0	0	11751	903	32	1	504	1	PEX7	6	137167279	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4966120	137167279	33947788	201	18596										
FUCA2	2519	broad.mit.edu	37	chr6	143828485	143828485	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaatagtggtccaaaatcttCatatttgaaactaggagggt	9	5	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:143828485C>T	uc003qjm.2	-	2	393	c.301G>A	c.(301-303)GAA>AAA	p.E101K		NM_032020	NP_114409	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma precursor	101					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		CCAAAATCTTCATATTTGAAA	0.373													0	0	0	0.008291	0	8	128										T	143828485	C	T	143828485	3	4	63	1	0	0	0	0	1	0	0	0	6095	835	29	1	1126	1	FUCA2	6	143828485	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	6661206	143828485	27286582	202	18597										
SYNE1	23345	broad.mit.edu	37	chr6	152702384	152702384	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcggcacgcagggcctgcatCtccgtgtgcatgagctcaca	12	14	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:152702384C>G	uc010kiw.2	-	56	9368	c.8766G>C	c.(8764-8766)GAG>GAC	p.E2922D	SYNE1_uc003qot.3_Missense_Mutation_p.E2929D|SYNE1_uc003qou.3_Missense_Mutation_p.E2922D|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_5'UTR|SYNE1_uc010kjb.1_Missense_Mutation_p.E2905D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2922	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGGCCTGCATCTCCGTGTGCA	0.577										HNSCC(10;0.0054)			0	0	0	0.00245	0	11	146										G	152702384	C	G	152702384	3	3	63	1	0	0	0	0	1	0	0	0	15442	912	32	1	18064	1	SYNE1	6	152702384	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	8873899	152702384	18412683	203	18598										
SLC22A1	6580	broad.mit.edu	37	chr6	160555032	160555032	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccagaagaacggtggcgatCatgtaccagatggccttcac	11	11	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:160555032C>T	uc003qtc.2	+	4	819	c.714C>T	c.(712-714)ATC>ATT	p.I238I	SLC22A1_uc003qtd.2_Silent_p.I238I	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	238	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		CGGTGGCGATCATGTACCAGA	0.632													0	0	0	0.001984	0	5	66										T	160555032	C	T	160555032	2	4	63	1	0	0	0	0	0	0	0	1	14440	816	29	1		1	SLC22A1	6	160555032	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	7852648	160555032	10560035	204	18599										
LPA	4018	broad.mit.edu	37	chr6	160978430	160978430	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagacttcttacctgcttcaGaatgagcctccatgcttgga	8	12	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:160978430G>C	uc003qtl.2	-	30	4925	c.4805C>G	c.(4804-4806)TCT>TGT	p.S1602C		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4110	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ACCTGCTTCAGAATGAGCCTC	0.458													0	0	0	0.006214	0	7	111										C	160978430	G	C	160978430	3	2	63	1	0	0	0	0	1	0	0	0	8903	942	33	1	1361	1	LPA	6	160978430	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	423398	160978430	10136637	205	18600										
THBS2	7058	broad.mit.edu	37	chr6	169623568	169623568	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acaaatatcaccccgtccatCacctatgcacaaagaacaag	4	14	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:169623568C>A	uc003qwt.2	-	19	3024	c.2776G>T	c.(2776-2778)GAT>TAT	p.D926Y		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	926	TSP type-3 8.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCCCGTCCATCACCTATGCAC	0.373													1	0	3.59834e-05	0.001168	3.77448e-05	6	85										A	169623568	C	A	169623568	3	1	63	1	0	0	0	0	1	0	0	0	15851	826	29	3	762	3	THBS2	6	169623568	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	8645138	169623568	1491499	206	18601										
AHR	196	broad.mit.edu	37	chr7	17382607	17382607	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aataacataaataacactcaGactaccacacatcttcagcc	2	13	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:17382607G>C	uc011jxz.1	+	11	3079	c.2466G>C	c.(2464-2466)CAG>CAC	p.Q822H	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	822				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATAACACTCAGACTACCACAC	0.368													0	0	0	0.01441	0	45	149										C	17382607	G	C	17382607	3	2	63	1	0	0	0	0	1	0	0	0	416	933	33	1	2508	1	AHR	7	17382607	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		17382607	141756056	207	18602										
NPSR1	387129	broad.mit.edu	37	chr7	34917785	34917785	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caggtgtaccttcctgggctCttccaaggtgacagctctca	10	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:34917785C>T	uc003tei.1	+	9	1251	c.1123C>T	c.(1123-1125)CTT>TTT	p.L375F	NPSR1_uc010kww.1_Missense_Mutation_p.L364F|NPSR1_uc011kar.1_Missense_Mutation_p.L309F	NM_207173	NP_997056	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	Error:Variant_position_missing_in_Q6W5P4_after_alignment						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TTCCTGGGCTCTTCCAAGGTG	0.557													0	0	0	0.009096	0	4	17										T	34917785	C	T	34917785	3	4	63	1	0	0	0	0	1	0	0	0	10600	913	32	1	1252	1	NPSR1	7	34917785	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	17535178	34917785	124220878	208	18603										
TARP	445347	broad.mit.edu	37	chr7	38304969	38304969	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cctgtctttattggaggaaaGataatttcttgatcaactcc	7	8	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:38304969G>C	uc003tge.1	-	5	1115	c.738C>G	c.(736-738)ATC>ATG	p.I246M	uc003tfz.1_Intron|TARP_uc003tgb.2_Missense_Mutation_p.I42M|TARP_uc003tgc.1_Missense_Mutation_p.I42M|TARP_uc003tgd.1_Missense_Mutation_p.I42M|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						TTGGAGGAAAGATAATTTCTT	0.348													0	0	0	0.009096	0	4	33										C	38304969	G	C	38304969	3	2	63	1	0	0	0	0	1	0	0	0	15555	932	33	1	221	1	TARP	7	38304969	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3387184	38304969	120833694	209	18604										
PKD1L1	168507	broad.mit.edu	37	chr7	47898448	47898448	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgagcaaggagtgcccgggtGtacttgaggatgagaaccgc	16	8	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:47898448G>A	uc003tny.1	-	27	4185	c.4185C>T	c.(4183-4185)TAC>TAT	p.Y1395Y		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1395	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GTGCCCGGGTGTACTTGAGGA	0.502													0	0	0	0.009096	0	3	49										A	47898448	G	A	47898448	2	1	63	1	0	0	0	0	0	0	0	1	11964	1372	48	2		2	PKD1L1	7	47898448	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	9593479	47898448	111240215	210	18605										
TPST1	8460	broad.mit.edu	37	chr7	65705934	65705934	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acttacctttctaggttattCcccaatgccaaatttctcct	3	13	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:65705934C>T	uc003tuw.2	+	2	874	c.522C>T	c.(520-522)TTC>TTT	p.F174F	TPST1_uc010kzy.2_Intron|TPST1_uc010kzz.2_Silent_p.F174F|TPST1_uc010laa.2_Silent_p.F174F	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	174	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						CTAGGTTATTCCCCAATGCCA	0.398													0	0	0	0.000602	0	5	68										T	65705934	C	T	65705934	2	4	63	1	0	0	0	0	0	0	0	1	16424	854	30	1		1	TPST1	7	65705934	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	17807486	65705934	93432729	211	18606										
BAZ1B	9031	broad.mit.edu	37	chr7	72891929	72891929	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catctggtaaaagtagcccaGaataacagctcaagaattcc	7	10	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:72891929G>C	uc003tyc.2	-	7	2207	c.1862C>G	c.(1861-1863)TCT>TGT	p.S621C		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	621	DDT.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				AAGTAGCCCAGAATAACAGCT	0.478													0	0	0	0.000602	0	5	59										C	72891929	G	C	72891929	3	2	63	1	0	0	0	0	1	0	0	0	1330	942	33	1	2641	1	BAZ1B	7	72891929	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	7185995	72891929	86246734	212	18607										
PCLO	27445	broad.mit.edu	37	chr7	82579161	82579161	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttgggtggagatgtggcactCagatattgaggactttgtgt	15	4	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:82579161C>T	uc003uhx.2	-	6	11032	c.10743G>A	c.(10741-10743)CTG>CTA	p.L3581L	PCLO_uc003uhv.2_Silent_p.L3581L|PCLO_uc010lec.2_Silent_p.L546L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3512					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATGTGGCACTCAGATATTGAG	0.438													0	0	0	0.001984	0	7	52										T	82579161	C	T	82579161	2	4	63	1	0	0	0	0	0	0	0	1	11583	813	29	1		1	PCLO	7	82579161	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	9687232	82579161	76559502	213	18608										
GRM3	2913	broad.mit.edu	37	chr7	86469220	86469220	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtgacatcaagtgactacaGagtaagtctttgattgtttc	9	6	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:86469220G>A	uc003uid.2	+	4	3489	c.2390G>A	c.(2389-2391)AGA>AAA	p.R797K	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.R669K|GRM3_uc010leh.2_Missense_Mutation_p.R389K	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	797	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGTGACTACAGAGTAAGTCTT	0.353													0	0	0	0.001168	0	5	74										A	86469220	G	A	86469220	3	1	63	1	0	0	0	0	1	0	0	0	6798	956	33	1	2400	1	GRM3	7	86469220	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3890059	86469220	72669443	214	18609										
ADAM22	53616	broad.mit.edu	37	chr7	87757941	87757941	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtcgatatcctcgtaatgtaGaagaagaaaccaaatacatt	7	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:87757941G>C	uc003ujn.2	+	9	782	c.703G>C	c.(703-705)GAA>CAA	p.E235Q	ADAM22_uc003uji.1_Missense_Mutation_p.E234Q|ADAM22_uc003ujj.1_Missense_Mutation_p.E235Q|ADAM22_uc003ujk.1_Missense_Mutation_p.E235Q|ADAM22_uc003ujl.1_Missense_Mutation_p.E235Q|ADAM22_uc003ujm.2_Missense_Mutation_p.E235Q|ADAM22_uc003ujo.2_Missense_Mutation_p.E235Q|ADAM22_uc003ujp.1_Missense_Mutation_p.E287Q	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	235	Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TCGTAATGTAGAAGAAGAAAC	0.393													0	0	0	0.008291	0	9	133										C	87757941	G	C	87757941	3	2	63	1	0	0	0	0	1	0	0	0	244	943	33	1	737	1	ADAM22	7	87757941	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1288721	87757941	71380722	215	18610										
MCM7	4176	broad.mit.edu	37	chr7	99695470	99695470	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctcacctgcaatttgcctCagctcctccctggtgagctc	7	18	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:99695470C>G	uc003usw.1	-	8	1482	c.972G>C	c.(970-972)CTG>CTC	p.L324L	MCM7_uc003usv.1_Silent_p.L148L|MCM7_uc003usx.1_Silent_p.L148L	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	324					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CAATTTGCCTCAGCTCCTCCC	0.493													0	0	0	0.010729	0	10	122										G	99695470	C	G	99695470	2	3	63	1	0	0	0	0	0	0	0	1	9392	813	29	1		1	MCM7	7	99695470	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	11937529	99695470	59443193	216	18611										
ZCWPW1	55063	broad.mit.edu	37	chr7	99998716	99998716	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccccgctctgccccagctctCtcccaacatcttccatgagt	5	20	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:99998716C>G	uc003uut.2	-	18	2116	c.1868G>C	c.(1867-1869)AGA>ACA	p.R623T	ZCWPW1_uc011kjq.1_Missense_Mutation_p.R503T|ZCWPW1_uc003uur.2_3'UTR|ZCWPW1_uc003uus.2_Missense_Mutation_p.R452T|ZCWPW1_uc011kjr.1_3'UTR|ZCWPW1_uc011kjp.1_RNA	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	623							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCCAGCTCTCTCCCAACATC	0.622													0	0	0	0.00308	0	5	53										G	99998716	C	G	99998716	3	3	63	1	0	0	0	0	1	0	0	0	17594	913	32	1	82	1	ZCWPW1	7	99998716	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	303246	99998716	59139947	217	18612										
GIGYF1	64599	broad.mit.edu	37	chr7	100283075	100283075	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggagctggacttctcctcctGaggaggcagtggggtcagct	16	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:100283075G>A	uc003uwg.1	-	10	2093	c.1084C>T	c.(1084-1086)CAG>TAG	p.Q362*		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	362										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTCTCCTCCTGAGGAGGCAGT	0.627													0	0	0	0.009096	0	4	30										A	100283075	G	A	100283075	4	1	63	1	0	0	0	0	0	1	0	0	6377	1299	45	1	2083	1	GIGYF1	7	100283075	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	284359	100283075	58855588	218	18613										
MUC17	140453	broad.mit.edu	37	chr7	100696366	100696366	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtgggggcaggggtcgtgctGatgctgatcatcctggtagc	18	8	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:100696366G>A	uc003uxp.1	+	10	13256	c.13203G>A	c.(13201-13203)CTG>CTA	p.L4401L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4401	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGGTCGTGCTGATGCTGATCA	0.597													0	0	0	0.001984	0	6	47										A	100696366	G	A	100696366	2	1	63	1	0	0	0	0	0	0	0	1	9974	1277	45	1		1	MUC17	7	100696366	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	413291	100696366	58442297	219	18614										
ORC5L	5001	broad.mit.edu	37	chr7	103848302	103848302	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctccaaacaaggactgcaaGatggacacttgagactcgcg	10	11	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:103848302G>A	uc003vcb.2	-	1	162	c.51C>T	c.(49-51)ATC>ATT	p.I17I	ORC5L_uc011klp.1_5'UTR|ORC5L_uc003vcc.2_Silent_p.I17I|ORC5L_uc003vcd.2_Silent_p.I17I	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	17					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						AGGACTGCAAGATGGACACTT	0.517													0	0	0	0.013537	0	11	100										A	103848302	G	A	103848302	2	1	63	1	0	0	0	0	0	0	0	1	11265	932	33	1		1	ORC5L	7	103848302	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3151936	103848302	55290361	220	18615										
LAMB1	3912	broad.mit.edu	37	chr7	107626630	107626630	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaaacaaacctctccttcaGttgagggttcaatgtcagaa	8	10	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:107626630G>T	uc003vew.2	-	6	937	c.602C>A	c.(601-603)ACT>AAT	p.T201N	LAMB1_uc003vev.2_Missense_Mutation_p.T225N|LAMB1_uc003vex.2_Missense_Mutation_p.T201N|LAMB1_uc010ljn.1_Missense_Mutation_p.T287N	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	201	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTCCTTCAGTTGAGGGTTC	0.378													1	0	2.23348e-06	0.004007	2.3845e-06	13	74										T	107626630	G	T	107626630	3	4	63	1	0	0	0	0	1	0	0	0	8610	1029	36	4	4874	4	LAMB1	7	107626630	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3778328	107626630	51512033	221	18616										
IMMP2L	83943	broad.mit.edu	37	chr7	110526696	110526696	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtgtccatgatgatcaccttCaacccagatgtgaccacggg	10	12	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:110526696C>T	uc003vfq.1	-	5	804	c.361G>A	c.(361-363)GAA>AAA	p.E121K	IMMP2L_uc010ljr.1_Missense_Mutation_p.E121K	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	121					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		TGATCACCTTCAACCCAGATG	0.403													0	0	0	0.00308	0	6	73										T	110526696	C	T	110526696	3	4	63	1	0	0	0	0	1	0	0	0	7717	835	29	1	174	1	IMMP2L	7	110526696	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2900066	110526696	48611967	222	18617										
EXOC4	60412	broad.mit.edu	37	chr7	132973814	132973814	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agaatatcaagcaagtgcctCaaaagctggaacagtgcatg	10	8	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:132973814C>G	uc003vrk.2	+	3	450	c.415C>G	c.(415-417)CAA>GAA	p.Q139E	EXOC4_uc011kpo.1_Missense_Mutation_p.Q38E|EXOC4_uc003vri.2_Missense_Mutation_p.Q139E|EXOC4_uc003vrj.2_Missense_Mutation_p.Q139E	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	139					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GCAAGTGCCTCAAAAGCTGGA	0.443													0	0	0	0.006214	0	8	40										G	132973814	C	G	132973814	3	3	63	1	0	0	0	0	1	0	0	0	5306	827	29	1	425	1	EXOC4	7	132973814	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	22447118	132973814	26164849	223	18618										
AKR1D1	6718	broad.mit.edu	37	chr7	137782615	137782615	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttttttttttttttcagccaGgagatgaaatataccctaga	6	6	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:137782615G>A	uc003vtz.2	+	4	451	c.382G>A	c.(382-384)GGA>AGA	p.G128R	AKR1D1_uc011kqb.1_Missense_Mutation_p.G128R|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.G128R|AKR1D1_uc011kqf.1_Missense_Mutation_p.G128R|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	128					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						ttttCAGCCAGGAGATGAAAT	0.234													0	0	0	0.007291	0	25	74										A	137782615	G	A	137782615	3	1	63	1	0	0	0	0	1	0	0	0	473	1001	35	2	396	2	AKR1D1	7	137782615	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4808801	137782615	21356048	224	18619										
JHDM1D	80853	broad.mit.edu	37	chr7	139826545	139826545	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgaacaaatggcttgggaaaGactgaatcatctggccaata	10	7	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:139826545G>C	uc003vvm.2	-	6	784	c.780C>G	c.(778-780)GTC>GTG	p.V260V		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	260	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GCTTGGGAAAGACTGAATCAT	0.403													0	0	0	0.013537	0	13	84										C	139826545	G	C	139826545	2	2	63	1	0	0	0	0	0	0	0	1	7948	929	33	1		1	JHDM1D	7	139826545	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2043930	139826545	19312118	225	18620										
MGAM	8972	broad.mit.edu	37	chr7	141752666	141752666	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgttcagtataattcccatgGggccacagctgacatctcct	8	12	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:141752666G>A	uc003vwy.2	+	26	3095	c.3041G>A	c.(3040-3042)GGG>GAG	p.G1014E		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1014	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AATTCCCATGGGGCCACAGCT	0.463													0	0	0	0.00278	0	21	103										A	141752666	G	A	141752666	3	1	63	1	0	0	0	0	1	0	0	0	9541	1232	43	2	3139	2	MGAM	7	141752666	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1926121	141752666	17385997	226	18621										
MGAM	8972	broad.mit.edu	37	chr7	141759285	141759285	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cccgcaggatgtgcagtactCagacatcgactacatggagc	11	12	1	1	rs146623163	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:141759285C>G	uc003vwy.2	+	32	3887	c.3833C>G	c.(3832-3834)TCA>TGA	p.S1278*		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1278	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTGCAGTACTCAGACATCGAC	0.567													0	0	0	0.00308	0	8	24										G	141759285	C	G	141759285	4	3	63	1	0	0	0	0	0	1	0	0	9541	838	29	1	3955	1	MGAM	7	141759285	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	6619	141759285	17379378	227	18622										
ARHGEF35	445328	broad.mit.edu	37	chr7	143884376	143884376	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcccgctgactgggaccccTttctcctttataccatgatc	7	15	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:143884376T>G	uc003wdz.1	-	2	1219	c.1101A>C	c.(1099-1101)AAA>AAC	p.K367N		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	367	Glu-rich.										0						CTGGGACCCCTTTCTCCTTTA	0.537													0	0	0	0.009096	0	4	32										G	143884376	T	G	143884376	3	3	63	1	0	0	0	0	1	0	0	0	905	1606	56	5	357	5	ARHGEF35	7	143884376	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	2125091	143884376	15254287	228	18623										
MLL3	58508	broad.mit.edu	37	chr7	151927028	151927028	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttaatactgacacagtatgGatggtaacactgaccacact	7	10	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:151927028G>C	uc003wla.2	-	18	3175	c.2956C>G	c.(2956-2958)CCA>GCA	p.P986A	MLL3_uc003wkz.2_Missense_Mutation_p.P47A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	986	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACACAGTATGGATGGTAACAC	0.368			N		medulloblastoma								0	0	0	0.004656	0	10	403										C	151927028	G	C	151927028	3	2	63	1	0	0	0	0	1	0	0	0	9622	1174	41	1	11947	1	MLL3	7	151927028	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8042652	151927028	7211635	229	18624										
ARHGEF10	9639	broad.mit.edu	37	chr8	1806263	1806263	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caggaggtgctggagccagtGaagcccctgcacccacaggt	14	13	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:1806263G>A	uc003wpr.2	+	3	353	c.175G>A	c.(175-177)GAA>AAA	p.E59K	ARHGEF10_uc003wpq.1_Missense_Mutation_p.E83K|ARHGEF10_uc003wps.2_Missense_Mutation_p.E59K|ARHGEF10_uc003wpt.2_5'Flank|ARHGEF10_uc010lrd.1_5'Flank|ARHGEF10_uc003wpu.2_5'Flank	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	83					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TGGAGCCAGTGAAGCCCCTGC	0.338													0	0	0	0.009096	0	4	24										A	1806263	G	A	1806263	3	1	63	1	0	0	0	0	1	0	0	0	894	1291	45	1	181	1	ARHGEF10	8	1806263	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		1806263	144557759	230	18625										
ASAH1	427	broad.mit.edu	37	chr8	17928835	17928835	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgccttgtcaagcatcaattCatgccatcttttgtagggtg	9	9	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:17928835C>T	uc003wyl.2	-	3	502	c.190G>A	c.(190-192)GAA>AAA	p.E64K	ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_Missense_Mutation_p.E64K|ASAH1_uc003wyn.2_Missense_Mutation_p.E80K|ASAH1_uc003wyo.2_Missense_Mutation_p.E87K	NM_177924	NP_808592	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase 1 isoform a	64					ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		AGCATCAATTCATGCCATCTT	0.299													0	0	0	0.001984	0	4	22										T	17928835	C	T	17928835	3	4	63	1	0	0	0	0	1	0	0	0	1006	835	29	1	1045	1	ASAH1	8	17928835	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	16122572	17928835	128435187	231	18626										
RB1CC1	9821	broad.mit.edu	37	chr8	53586766	53586766	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccagtcttcccaaacattctCtgtaactatgtctggttagg	7	11	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:53586766C>G	uc003xre.3	-	7	1199	c.641G>C	c.(640-642)AGA>ACA	p.R214T	RB1CC1_uc003xrf.3_Missense_Mutation_p.R214T	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	214					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CAAACATTCTCTGTAACTATG	0.398													0	0	0	0.006214	0	9	135										G	53586766	C	G	53586766	3	3	63	1	0	0	0	0	1	0	0	0	13099	913	32	1	4215	1	RB1CC1	8	53586766	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	35657931	53586766	92777256	232	18627										
RP1	6101	broad.mit.edu	37	chr8	55533796	55533796	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agcacccctcggggcaggcaCagcatcacgcgcctggagga	14	15	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:55533796C>T	uc003xsd.1	+	2	418	c.270C>T	c.(268-270)CAC>CAT	p.H90H	RP1_uc011ldy.1_Silent_p.H90H	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	90	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGGGCAGGCACAGCATCACGC	0.607													0	0	0	0.006214	0	8	132										T	55533796	C	T	55533796	2	4	63	1	0	0	0	0	0	0	0	1	13532	477	17	2		2	RP1	8	55533796	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1947030	55533796	90830226	233	18628										
UBXN2B	137886	broad.mit.edu	37	chr8	59345738	59345738	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtcatttacaggtggaggatAcagattgggtagttcttttt	12	4	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:59345738A>T	uc003xtl.2	+	4	481	c.359A>T	c.(358-360)TAC>TTC	p.Y120F		NM_001077619	NP_001071087	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	120						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				ovary(2)	2						GGTGGAGGATACAGATTGGGT	0.289													0	0	0	0.010504	0	15	242										T	59345738	A	T	59345738	3	4	63	1	0	0	0	0	1	0	0	0	16912	391	14	5	373	5	UBXN2B	8	59345738	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	3811942	59345738	87018284	234	18629										
VCPIP1	80124	broad.mit.edu	37	chr8	67576615	67576615	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggctgagtgtgctgcagcaGactgaccaccttcagcttta	12	11	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:67576615G>A	uc003xwn.2	-	1	2838	c.2579C>T	c.(2578-2580)TCT>TTT	p.S860F		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	860					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TGCTGCAGCAGACTGACCACC	0.428													0	0	0	0.001984	0	5	96										A	67576615	G	A	67576615	3	1	63	1	0	0	0	0	1	0	0	0	17138	942	33	1	1101	1	VCPIP1	8	67576615	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8230877	67576615	78787407	235	18630										
FAM82B	51115	broad.mit.edu	37	chr8	87486538	87486538	+	Silent	SNP	C	C	T													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatcttctctgaaaagttctCaattcttctcactgaaactt							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:87486538C>T	uc003ydu.2	-	10	1104	c.944G>A	c.(943-945)TGA>TAA	p.*315*	FAM82B_uc011lfz.1_Silent_p.*272*|FAM82B_uc011lga.1_Silent_p.*285*	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	315						microtubule|spindle pole	binding			ovary(1)	1						GAAAAGTTCTCAATTCTTCTC	0.299													0	0	0	0.006214	0	6	95										T	87486538	C	T	87486538	2	4	63	1	0	0	0	0	0	0	0	1	5632	837	29	1		1	FAM82B	8	87486538	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	19909923	87486538	58877484	236	18631	90	2								
FAM82B	51115	broad.mit.edu	37	chr8	87486543	87486543	+	Silent	SNP	C	C	T													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctctgaaaagttctcaattCttctcactgaaacttgtaag							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:87486543C>T	uc003ydu.2	-	10	1099	c.939G>A	c.(937-939)AAG>AAA	p.K313K	FAM82B_uc011lfz.1_Silent_p.K270K|FAM82B_uc011lga.1_Silent_p.K283K	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	313						microtubule|spindle pole	binding			ovary(1)	1						GTTCTCAATTCTTCTCACTGA	0.308													0	0	0	0.010729	0	9	100										T	87486543	C	T	87486543	2	4	63	1	0	0	0	0	0	0	0	1	5632	912	32	1		1	FAM82B	8	87486543	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5	87486543	58877479	237	18632	90	2								
DCAF4L2	138009	broad.mit.edu	37	chr8	88885230	88885230	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgccacgactccttcttcttCgttcacatgcacgggtaggt	9	14	3	0	rs138662456	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:88885230C>A	uc003ydz.2	-	1	1067	c.970G>T	c.(970-972)GAA>TAA	p.E324*		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	324	WD 2.									ovary(1)	1						CCTTCTTCTTCGTTCACATGC	0.552													1	0	0.00448238	0.004482	0.00458947	8	57										A	88885230	C	A	88885230	4	1	63	1	0	0	0	0	0	1	0	0	4272	893	31	3	221	3	DCAF4L2	8	88885230	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1398687	88885230	57478792	238	18633										
VPS13B	157680	broad.mit.edu	37	chr8	100712095	100712095	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	accccataccagcaaaccatGcctgttagcatctctctcaa	4	16	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:100712095G>A	uc003yiv.2	+	36	6575	c.6464G>A	c.(6463-6465)TGC>TAC	p.C2155Y	VPS13B_uc003yiw.2_Missense_Mutation_p.C2130Y	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2155					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGCAAACCATGCCTGTTAGCA	0.443													0	0	0	0.004482	0	8	56										A	100712095	G	A	100712095	3	1	63	1	0	0	0	0	1	0	0	0	17187	1319	46	2	6796	2	VPS13B	8	100712095	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	11826865	100712095	45651927	239	18634										
ODF1	4956	broad.mit.edu	37	chr8	103564039	103564039	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctaaggcaactgagatgcatCgacgaatttagcacacggtg	11	9	0	1	rs142790437		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:103564039C>T	uc003ykt.2	+	1	192	c.84C>T	c.(82-84)ATC>ATT	p.I28I		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	28					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			TGAGATGCATCGACGAATTTA	0.483													0	0	0	0.003954	0	25	145										T	103564039	C	T	103564039	2	4	63	1	0	0	0	0	0	0	0	1	10826	874	31	1		1	ODF1	8	103564039	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2851944	103564039	42799983	240	18635										
FZD6	8323	broad.mit.edu	37	chr8	104337008	104337008	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacttttttaattgatgttaGaagattcagatacccagaga	7	5	1	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:104337008G>C	uc003ylh.2	+	4	958	c.674G>C	c.(673-675)AGA>ACA	p.R225T	FZD6_uc003yli.2_Missense_Mutation_p.R225T|FZD6_uc003ylj.2_Missense_Mutation_p.R225T|FZD6_uc011lhn.1_Missense_Mutation_p.R191T|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Missense_Mutation_p.R170T	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	225	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATTGATGTTAGAAGATTCAGA	0.333													0	0	0	0.001168	0	6	47										C	104337008	G	C	104337008	3	2	63	1	0	0	0	0	1	0	0	0	6134	942	33	1	684	1	FZD6	8	104337008	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	772969	104337008	42027014	241	18636										
LRP12	29967	broad.mit.edu	37	chr8	105509412	105509412	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caacgattgtttttacaatgGaaatttcctggttggcaaaa	8	6	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:105509412G>A	uc003yma.2	-	5	1463	c.1368C>T	c.(1366-1368)TTC>TTT	p.F456F	LRP12_uc003ymb.2_Silent_p.F437F|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	456	Extracellular (Potential).|LDL-receptor class A 5.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTTTACAATGGAAATTTCCTG	0.418													0	0	0	0.008871	0	15	102										A	105509412	G	A	105509412	2	1	63	1	0	0	0	0	0	0	0	1	8954	1165	41	1		1	LRP12	8	105509412	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1172404	105509412	40854610	242	18637										
NUDCD1	84955	broad.mit.edu	37	chr8	110255327	110255327	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcctgaaatcctaaaatagGatcattggtttctaggcttg	9	7	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:110255327G>A	uc003ynb.3	-	10	1774	c.1663C>T	c.(1663-1665)CCT>TCT	p.P555S	NUDCD1_uc003yna.2_Missense_Mutation_p.P526S|NUDCD1_uc010mcl.2_Missense_Mutation_p.P468S	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	555										ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			CCTAAAATAGGATCATTGGTT	0.368													0	0	0	0.004289	0	32	212										A	110255327	G	A	110255327	3	1	63	1	0	0	0	0	1	0	0	0	10722	1174	41	1	92	1	NUDCD1	8	110255327	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4745915	110255327	36108695	243	18638										
CSMD3	114788	broad.mit.edu	37	chr8	113267562	113267562	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatcccactaatatgaaaggAaaattgcagctgaatgaaac	8	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:113267562A>G	uc003ynu.2	-	62	10116	c.9957T>C	c.(9955-9957)TTT>TTC	p.F3319F	CSMD3_uc003yns.2_Silent_p.F2521F|CSMD3_uc003ynt.2_Silent_p.F3279F|CSMD3_uc011lhx.1_Silent_p.F3150F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3319	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATATGAAAGGAAAATTGCAGC	0.413										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.006214	0	9	55										G	113267562	A	G	113267562	2	3	63	1	0	0	0	0	0	0	0	1	3946	243	9	5		5	CSMD3	8	113267562	Silent	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	3012235	113267562	33096460	244	18639										
NOV	4856	broad.mit.edu	37	chr8	120430374	120430374	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttcagccaagctgcaaattCcagtgcacctgcagagatgg	10	11	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:120430374C>A	uc003yoq.2	+	3	608	c.387C>A	c.(385-387)TTC>TTA	p.F129L		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	129	VWFC.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTGCAAATTCCAGTGCACCT	0.527													1	0	1.12685e-05	0.004482	1.19034e-05	9	56										A	120430374	C	A	120430374	3	1	63	1	0	0	0	0	1	0	0	0	10553	854	30	3	397	3	NOV	8	120430374	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	7162812	120430374	25933648	245	18640										
TG	7038	broad.mit.edu	37	chr8	133880419	133880419	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcagagggaaacggcctttCtgaagcaagcagactacgtg	13	9	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:133880419C>T	uc003ytw.2	+	2	168	c.127C>T	c.(127-129)CTG>TTG	p.L43L		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	43	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AACGGCCTTTCTGAAGCAAGC	0.517													0	0	0	0.013537	0	9	83										T	133880419	C	T	133880419	2	4	63	1	0	0	0	0	0	0	0	1	15810	912	32	1		1	TG	8	133880419	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	13450045	133880419	12483603	246	18641										
TG	7038	broad.mit.edu	37	chr8	133945805	133945805	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	accgtcccatggtgcttgcaGattgcacagaggacgaggcc	13	12	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:133945805G>A	uc003ytw.2	+	24	4858	c.4817_splice	c.e24-1	p.D1606_splice	TG_uc010mdw.2_Splice_Site_p.D365_splice|TG_uc011ljb.1_Splice_Site_p.D39_splice	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGTGCTTGCAGATTGCACAGA	0.567													0	0	0	0.00245	0	10	105										A	133945805	G	A	133945805	5	1	63	1	0	0	0	0	0	0	1	0	15810	956	33	1	4910	1	TG	8	133945805	Splice_Site	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	65386	133945805	12418217	247	18642										
FAM135B	51059	broad.mit.edu	37	chr8	139158273	139158273	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttctatgaaagtctttaccaGccggaggtctgcactgttcc	9	11	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:139158273G>T	uc003yuy.2	-	15	3640	c.3469C>A	c.(3469-3471)CTG>ATG	p.L1157M	FAM135B_uc003yux.2_Missense_Mutation_p.L1058M|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.L719M|FAM135B_uc003yvb.2_Missense_Mutation_p.A684D	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1157										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTCTTTACCAGCCGGAGGTCT	0.433										HNSCC(54;0.14)			1	0	0.00010058	0.013537	0.000104953	12	51										T	139158273	G	T	139158273	3	4	63	1	0	0	0	0	1	0	0	0	5449	962	34	4	775	4	FAM135B	8	139158273	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5212468	139158273	7205749	248	18643										
FAM135B	51059	broad.mit.edu	37	chr8	139160802	139160802	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gacaaccaggtgaattccatCttccaaattttcttcctctt	4	12	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:139160802C>T	uc003yuy.2	-	14	3580	c.3409G>A	c.(3409-3411)GAT>AAT	p.D1137N	FAM135B_uc003yux.2_Missense_Mutation_p.D1038N|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.D699N|FAM135B_uc003yvb.2_Missense_Mutation_p.R664K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1137										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAATTCCATCTTCCAAATTT	0.358										HNSCC(54;0.14)			0	0	0	0.00245	0	11	86										T	139160802	C	T	139160802	3	4	63	1	0	0	0	0	1	0	0	0	5449	913	32	1	839	1	FAM135B	8	139160802	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2529	139160802	7203220	249	18644										
FAM135B	51059	broad.mit.edu	37	chr8	139278012	139278012	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttatgggtacctcttcattCcggtataagatctgaaagac	8	8	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:139278012C>G	uc003yuy.2	-	4	402	c.231G>C	c.(229-231)CGG>CGC	p.R77R	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	77										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCTCTTCATTCCGGTATAAGA	0.493										HNSCC(54;0.14)			0	0	0	0.001984	0	6	74										G	139278012	C	G	139278012	2	3	63	1	0	0	0	0	0	0	0	1	5449	842	30	1		1	FAM135B	8	139278012	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	117210	139278012	7086010	250	18645										
NAPRT1	93100	broad.mit.edu	37	chr8	144660103	144660103	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggggcagcaccgaggccagGaactgcacgtctggaaacga	16	11	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144660103G>C	uc003yym.3	-	2	262	c.237C>G	c.(235-237)TTC>TTG	p.F79L	NAPRT1_uc003yyn.3_Missense_Mutation_p.F79L|NAPRT1_uc011lkh.1_Missense_Mutation_p.F79L|NAPRT1_uc003yyo.3_Missense_Mutation_p.F79L	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	79					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCGAGGCCAGGAACTGCACGT	0.672													0	0	0	0.000602	0	3	62										C	144660103	G	C	144660103	3	2	63	1	0	0	0	0	1	0	0	0	10165	1165	41	1	1427	1	NAPRT1	8	144660103	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5382091	144660103	1703919	251	18646										
PUF60	22827	broad.mit.edu	37	chr8	144899273	144899273	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggggttcaccactcccaccGaggggatggtgaccgggata	15	11	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144899273G>A	uc003yzs.2	-	11	1251	c.1187C>T	c.(1186-1188)TCG>TTG	p.S396L	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Missense_Mutation_p.S336L|PUF60_uc003yzt.2_Missense_Mutation_p.S379L|PUF60_uc003yzq.2_Missense_Mutation_p.S353L|PUF60_uc003yzu.1_Missense_Mutation_p.S385L	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	396	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CACTCCCACCGAGGGGATGGT	0.612													0	0	0	0.009096	0	3	17										A	144899273	G	A	144899273	3	1	63	1	0	0	0	0	1	0	0	0	12824	1059	37	1	500	1	PUF60	8	144899273	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	239170	144899273	1464749	252	18647										
NRBP2	340371	broad.mit.edu	37	chr8	144921577	144921577	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggggggctgcaggcgtgcagGaagctgcagacgttggggag	22	7	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144921577G>C	uc011lkt.1	-	6	629	c.489C>G	c.(487-489)TTC>TTG	p.F163L	NRBP2_uc003yzv.2_5'UTR|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_5'UTR|NRBP2_uc011lks.1_5'UTR|NRBP2_uc003yzy.2_5'UTR	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	163	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGGCGTGCAGGAAGCTGCAGA	0.667													0	0	0	0.001168	0	5	10										C	144921577	G	C	144921577	3	2	63	1	0	0	0	0	1	0	0	0	10643	1165	41	1	1068	1	NRBP2	8	144921577	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	22304	144921577	1442445	253	18648										
EPPK1	83481	broad.mit.edu	37	chr8	144940861	144940861	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccgtgattatggctgagctGaggagttcagaagctgtgat	14	6	1	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144940861G>A	uc003zaa.1	-	1	6574	c.6561C>T	c.(6559-6561)CTC>CTT	p.L2187L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2187						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCTGAGCTGAGGAGTTCAG	0.537													0	0	0	0.003271	0	26	210										A	144940861	G	A	144940861	2	1	63	1	0	0	0	0	0	0	0	1	5190	1277	45	1		1	EPPK1	8	144940861	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	19284	144940861	1423161	254	18649			3	85		4	4	942	G		6.67211e-07
EPPK1	83481	broad.mit.edu	37	chr8	144940900	144940900	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atctgtcgtctaattccttgGaaccacaggtgtttgttgct	9	9	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144940900G>C	uc003zaa.1	-	1	6535	c.6522C>G	c.(6520-6522)TTC>TTG	p.F2174L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2174						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TAATTCCTTGGAACCACAGGT	0.527													0	0	0	0.010504	0	19	166										C	144940900	G	C	144940900	3	2	63	1	0	0	0	0	1	0	0	0	5190	1165	41	1	744	1	EPPK1	8	144940900	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	39	144940900	1423122	255	18650			3	85		4	4	942	G		6.67211e-07
EPPK1	83481	broad.mit.edu	37	chr8	144941013	144941013	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atacatcctcaccagctggaGcttcttctcctctgtcacgt	6	15	5	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144941013G>C	uc003zaa.1	-	1	6422	c.6409C>G	c.(6409-6411)CTC>GTC	p.L2137V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2137						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCAGCTGGAGCTTCTTCTCC	0.517													0	0	0	0.010504	0	19	136										C	144941013	G	C	144941013	3	2	63	1	0	0	0	0	1	0	0	0	5190	971	34	4	857	4	EPPK1	8	144941013	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	113	144941013	1423009	256	18651			3	85		4	4	942	G		6.67211e-07
EPPK1	83481	broad.mit.edu	37	chr8	144941802	144941802	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcccccagtcctccccacacGaagtgtgtgcagggtcttct	9	16	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144941802G>A	uc003zaa.1	-	1	5633	c.5620C>T	c.(5620-5622)CGT>TGT	p.R1874C		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1874						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCCCCACACGAAGTGTGTGC	0.607													0	0	0	0.004482	0	9	36										A	144941802	G	A	144941802	3	1	63	1	0	0	0	0	1	0	0	0	5190	1058	37	1	1646	1	EPPK1	8	144941802	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	789	144941802	1422220	257	18652			3	85		4	4	942	G		6.67211e-07
SMARCA2	6595	broad.mit.edu	37	chr9	2054650	2054650	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	actggaaaatctgcctggctCtttgccaccagatttaagaa	8	10	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:2054650C>T	uc003zhc.2	+	6	1199	c.1100C>T	c.(1099-1101)TCT>TTT	p.S367F	SMARCA2_uc003zhd.2_Missense_Mutation_p.S367F|SMARCA2_uc010mha.2_Missense_Mutation_p.S358F	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	367					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CTGCCTGGCTCTTTGCCACCA	0.443													0	0	0	0.008871	0	17	82										T	2054650	C	T	2054650	3	4	63	1	0	0	0	0	1	0	0	0	14769	913	32	1	1118	1	SMARCA2	9	2054650	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		2054650	139158781	258	18653										
KIAA2026	158358	broad.mit.edu	37	chr9	5968412	5968412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tataaaccttatttcacctgGactaagaggctctccaaagc	6	11	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:5968412G>A	uc003zjq.3	-	3	2035	c.1819C>T	c.(1819-1821)CCA>TCA	p.P607S		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	607										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ATTTCACCTGGACTAAGAGGC	0.363													0	0	0	0.001984	0	5	74										A	5968412	G	A	5968412	3	1	63	1	0	0	0	0	1	0	0	0	8270	1174	41	1	4516	1	KIAA2026	9	5968412	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3913762	5968412	135245019	259	18654										
C9orf72	203228	broad.mit.edu	37	chr9	27566843	27566843	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagattaatgaaacaataatCactcccttttcagacaagac	4	9	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:27566843C>T	uc003zqq.2	-	2	373	c.276G>A	c.(274-276)GTG>GTA	p.V92V	C9orf72_uc003zqr.1_Silent_p.V92V	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	92										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		AAACAATAATCACTCCCTTTT	0.378													0	0	0	0.009096	0	3	39										T	27566843	C	T	27566843	2	4	63	1	0	0	0	0	0	0	0	1	2495	813	29	1		1	C9orf72	9	27566843	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	21598431	27566843	113646588	260	18655										
NFX1	4799	broad.mit.edu	37	chr9	33313681	33313681	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcgctgtggtcaggctgtctCagtccactgttctaacccat	9	13	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:33313681C>T	uc003zsq.2	+	7	1539	c.1478C>T	c.(1477-1479)TCA>TTA	p.S493L	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.S493L|NFX1_uc003zso.2_Missense_Mutation_p.S493L|NFX1_uc003zsp.1_Missense_Mutation_p.S493L|NFX1_uc010mjr.1_Missense_Mutation_p.S493L|NFX1_uc003zsr.2_Missense_Mutation_p.S493L	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	493					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		CAGGCTGTCTCAGTCCACTGT	0.483													0	0	0	0.012319	0	16	126										T	33313681	C	T	33313681	3	4	63	1	0	0	0	0	1	0	0	0	10387	838	29	1	1504	1	NFX1	9	33313681	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5746838	33313681	107899750	261	18656										
SIGMAR1	10280	broad.mit.edu	37	chr9	34635839	34635839	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gctgttgcctcaccaggcccGtgtactaccgtctcccctgg	10	17	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:34635839G>A	uc003zvb.2	-	4	536	c.462C>T	c.(460-462)CAC>CAT	p.H154H	SIGMAR1_uc003zva.3_Silent_p.H134H|SIGMAR1_uc003zuz.2_Silent_p.H65H|SIGMAR1_uc003zvc.2_Silent_p.H123H|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	154	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)	CACCAGGCCCGTGTACTACCG	0.647													0	0	0	0.00245	0	11	47										A	34635839	G	A	34635839	2	1	63	1	0	0	0	0	0	0	0	1	14316	1136	40	2		2	SIGMAR1	9	34635839	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1322158	34635839	106577592	262	18657										
GNE	10020	broad.mit.edu	37	chr9	36276902	36276902	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	attacttacatgaggtccttGaaagcatgactccctctgca	7	11	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:36276902G>A	uc010mli.2	-	1	140	c.40C>T	c.(40-42)CAA>TAA	p.Q14*	CLTA_uc003zzf.1_Intron|GNE_uc010mlj.2_Silent_p.F46F	NM_001128227	NP_001121699	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	Error:Variant_position_missing_in_Q9Y223_after_alignment					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			TGAGGTCCTTGAAAGCATGAC	0.403													0	0	0	0.014323	0	17	69										A	36276902	G	A	36276902	4	1	63	1	0	0	0	0	0	1	0	0	6522	1299	45	1	2269	1	GNE	9	36276902	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1641063	36276902	104936529	263	18658										
TBC1D2	55357	broad.mit.edu	37	chr9	100971023	100971023	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagcacccggcggagcttgtCggggaagctggaggtggggc	20	10	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:100971023C>T	uc011lvb.1	-	9	2257	c.2077G>A	c.(2077-2079)GAC>AAC	p.D693N	TBC1D2_uc004ayp.2_Missense_Mutation_p.D233N|TBC1D2_uc004ayq.2_Missense_Mutation_p.D693N|TBC1D2_uc004ayr.2_Missense_Mutation_p.D475N|TBC1D2_uc004ayo.3_Missense_Mutation_p.D693N	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	693	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CGGAGCTTGTCGGGGAAGCTG	0.642													0	0	0	0.009096	0	4	55										T	100971023	C	T	100971023	3	4	63	1	0	0	0	0	1	0	0	0	15605	884	31	1	696	1	TBC1D2	9	100971023	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	64694121	100971023	40242408	264	18659										
PTPN3	5774	broad.mit.edu	37	chr9	112166859	112166859	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagctggttcagttcatcttCagacttgaagtcagcaaatg	9	8	5	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:112166859C>T	uc004bed.2	-	19	1934	c.1822G>A	c.(1822-1824)GAA>AAA	p.E608K	PTPN3_uc004beb.2_Missense_Mutation_p.E477K|PTPN3_uc004bec.2_Missense_Mutation_p.E432K|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.E563K|PTPN3_uc011lwh.1_Missense_Mutation_p.E454K|PTPN3_uc011lwd.1_Missense_Mutation_p.E76K|PTPN3_uc011lwe.1_Missense_Mutation_p.E321K|PTPN3_uc011lwf.1_Missense_Mutation_p.E276K	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	608					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						agttcatcttcagacttgaag	0.373													0	0	0	0.004656	0	20	90										T	112166859	C	T	112166859	3	4	63	1	0	0	0	0	1	0	0	0	12789	835	29	1	951	1	PTPN3	9	112166859	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	11195836	112166859	29046572	265	18660										
COL27A1	85301	broad.mit.edu	37	chr9	116973287	116973287	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcctggcgttcctggcaagaGgggcaagatgggtatgccgg	18	9	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:116973287G>T	uc011lxl.1	+	12	2348	c.2348G>T	c.(2347-2349)AGG>ATG	p.R783M	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.R582M	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	783	Collagen-like 3.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CCTGGCAAGAGGGGCAAGATG	0.642													1	0	2.52707e-12	0.006214	2.77192e-12	6	94										T	116973287	G	T	116973287	3	4	63	1	0	0	0	0	1	0	0	0	3685	1000	35	4	2394	4	COL27A1	9	116973287	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4806428	116973287	24240144	266	18661										
DFNB31	25861	broad.mit.edu	37	chr9	117188538	117188538	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atccgggaactggcgatccaCttggtctcgtccacagtggt	12	12	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:117188538C>G	uc004biz.3	-	4	1768	c.1119G>C	c.(1117-1119)AAG>AAC	p.K373N	DFNB31_uc004bix.2_5'Flank|DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Missense_Mutation_p.K373N	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	373					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TGGCGATCCACTTGGTCTCGT	0.617													0	0	0	0.001984	0	6	54										G	117188538	C	G	117188538	3	3	63	1	0	0	0	0	1	0	0	0	4455	564	20	4	1640	4	DFNB31	9	117188538	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	215251	117188538	24024893	267	18662										
STRBP	55342	broad.mit.edu	37	chr9	125909232	125909232	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cattgtgaagactggggcatGaacggggccagactgagata	15	7	0	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:125909232G>T	uc004bns.2	-	13	1670	c.1240C>A	c.(1240-1242)CAT>AAT	p.H414N	STRBP_uc004bnt.2_Missense_Mutation_p.H232N|STRBP_uc004bnu.2_Missense_Mutation_p.H400N|STRBP_uc004bnv.2_Missense_Mutation_p.H414N|STRBP_uc004bnr.2_Missense_Mutation_p.H26N	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	414	DRBM 1.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						ACTGGGGCATGAACGGGGCCA	0.463													1	0	3.27435e-08	0.00245	3.53984e-08	13	114										T	125909232	G	T	125909232	3	4	63	1	0	0	0	0	1	0	0	0	15326	1290	45	3	806	3	STRBP	9	125909232	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8720694	125909232	15304199	268	18663										
DOLK	22845	broad.mit.edu	37	chr9	131709575	131709575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggccggagatgggcactctCgggtcatatctctagacctg	14	11	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:131709575C>T	uc004bwr.2	-	1	438	c.8G>A	c.(7-9)CGA>CAA	p.R3Q	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	3	Lumenal (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						TGGGCACTCTCGGGTCATATC	0.662													0	0	0	0.001855	0	10	53										T	131709575	C	T	131709575	3	4	63	1	0	0	0	0	1	0	0	0	4703	884	31	1	1612	1	DOLK	9	131709575	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5800343	131709575	9503856	269	18664										
KLF6	1316	broad.mit.edu	37	chr10	3823941	3823941	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cctgccgtcgggggaggcatCgccatttcccttgtcacctg	12	15	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:3823941C>T	uc001iha.2	-	2	835	c.568G>A	c.(568-570)GAT>AAT	p.D190N	KLF6_uc010qaj.1_Missense_Mutation_p.D190N|KLF6_uc010qak.1_Intron|KLF6_uc010qal.1_Intron|KLF6_uc001ihb.2_Missense_Mutation_p.D190N	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	190					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		GGGGAGGCATCGCCATTTCCC	0.627											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	57										T	3823941	C	T	3823941	3	4	63	1	0	0	0	0	1	0	0	0	8350	884	31	1	295	1	KLF6	10	3823941	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		3823941	131710806	270	18665										
KLF6	1316	broad.mit.edu	37	chr10	3824047	3824047	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agttgagaaggttccctgctCagttccggagaagatggagg	15	7	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:3824047C>G	uc001iha.2	-	2	729	c.462G>C	c.(460-462)CTG>CTC	p.L154L	KLF6_uc010qaj.1_Silent_p.L154L|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Silent_p.L154L|KLF6_uc001ihb.2_Silent_p.L154L	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	154					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		GTTCCCTGCTCAGTTCCGGAG	0.612											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	13	73										G	3824047	C	G	3824047	2	3	63	1	0	0	0	0	0	0	0	1	8350	813	29	1		1	KLF6	10	3824047	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	106	3824047	131710700	271	18666										
C10orf18	54906	broad.mit.edu	37	chr10	5791660	5791660	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cacactgtttcattccacctCaacaaactgaaatacaacag	3	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:5791660C>G	uc001iij.2	+	15	6901	c.6276C>G	c.(6274-6276)CTC>CTG	p.L2092L	C10orf18_uc001iik.2_Silent_p.L936L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2092										ovary(1)|central_nervous_system(1)	2						CATTCCACCTCAACAAACTGA	0.383													0	0	0	0.000602	0	4	37										G	5791660	C	G	5791660	2	3	63	1	0	0	0	0	0	0	0	1	1596	813	29	1		1	C10orf18	10	5791660	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1967613	5791660	129743087	272	18667										
FAM171A1	221061	broad.mit.edu	37	chr10	15296770	15296770	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaggaaaactgtccacctccGaaggggagctggcggccgtg	15	11	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:15296770G>A	uc001iob.2	-	4	534	c.527C>T	c.(526-528)TCG>TTG	p.S176L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	176	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GTCCACCTCCGAAGGGGAGCT	0.507													0	0	0	0.001168	0	5	32										A	15296770	G	A	15296770	3	1	63	1	0	0	0	0	1	0	0	0	5490	1059	37	1	2165	1	FAM171A1	10	15296770	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	9505110	15296770	120237977	273	18668										
CUBN	8029	broad.mit.edu	37	chr10	17107611	17107611	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agttaccactgcttgtgagaGatggcgggatcgactttcca	12	9	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:17107611G>A	uc001ioo.2	-	22	3087	c.3035C>T	c.(3034-3036)TCT>TTT	p.S1012F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1012	CUB 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCTTGTGAGAGATGGCGGGAT	0.403													0	0	0	0.004656	0	19	161										A	17107611	G	A	17107611	3	1	63	1	0	0	0	0	1	0	0	0	4051	942	33	1	8020	1	CUBN	10	17107611	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1810841	17107611	118427136	274	18669										
SVIL	6840	broad.mit.edu	37	chr10	29747179	29747179	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctctggcgtctccccactcaGaacaggccttttgctttctt	7	15	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:29747179G>A	uc001iut.1	-	38	7395	c.6642C>T	c.(6640-6642)TTC>TTT	p.F2214F	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.F1128F|SVIL_uc001iuu.1_Silent_p.F1788F	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2214	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TCCCCACTCAGAACAGGCCTT	0.502													0	0	0	0.000602	0	3	62										A	29747179	G	A	29747179	2	1	63	1	0	0	0	0	0	0	0	1	15418	933	33	1		1	SVIL	10	29747179	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	12639568	29747179	105787568	275	18670										
KIAA1462	57608	broad.mit.edu	37	chr10	30336610	30336610	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggccatcctcatgcccgttCtgcaggccctggcctgctcg	12	17	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:30336610C>T	uc001iux.2	-	1	191	c.132G>A	c.(130-132)CAG>CAA	p.Q44Q	KIAA1462_uc001iuy.2_Silent_p.Q44Q|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Silent_p.Q44Q	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	44										ovary(4)	4						CATGCCCGTTCTGCAGGCCCT	0.642													0	0	0	0.00308	0	6	41										T	30336610	C	T	30336610	2	4	63	1	0	0	0	0	0	0	0	1	8234	912	32	1		1	KIAA1462	10	30336610	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	589431	30336610	105198137	276	18671										
PARD3	56288	broad.mit.edu	37	chr10	34671692	34671692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccctgcactgttcacactcCtgttgtcaatatactggctg	8	13	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:34671692C>T	uc010qej.1	-	9	1175	c.1175G>A	c.(1174-1176)AGG>AAG	p.R392K	PARD3_uc010qek.1_Missense_Mutation_p.R392K|PARD3_uc010qel.1_Missense_Mutation_p.R392K|PARD3_uc010qem.1_Missense_Mutation_p.R392K|PARD3_uc010qen.1_Missense_Mutation_p.R392K|PARD3_uc010qeo.1_Missense_Mutation_p.R392K|PARD3_uc010qep.1_Missense_Mutation_p.R348K|PARD3_uc010qeq.1_Missense_Mutation_p.R348K|PARD3_uc001ixo.1_Missense_Mutation_p.R122K|PARD3_uc001ixp.1_Missense_Mutation_p.R257K|PARD3_uc001ixq.1_Missense_Mutation_p.R392K|PARD3_uc001ixr.1_Missense_Mutation_p.R392K|PARD3_uc001ixt.1_Missense_Mutation_p.R213K|PARD3_uc001ixu.1_Missense_Mutation_p.R348K|PARD3_uc001ixs.1_Missense_Mutation_p.R45K	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	392					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GTTCACACTCCTGTTGTCAAT	0.488													0	0	0	0.010729	0	10	75										T	34671692	C	T	34671692	3	4	63	1	0	0	0	0	1	0	0	0	11443	681	24	2	2998	2	PARD3	10	34671692	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4335082	34671692	100863055	277	18672										
NCOA4	8031	broad.mit.edu	37	chr10	51584877	51584877	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggcagtcgtgaaaccagtGagaagtttaagctcttattc	10	7	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:51584877G>C	uc001jis.3	+	8	1179	c.976G>C	c.(976-978)GAG>CAG	p.E326Q	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.E342Q|NCOA4_uc010qhd.1_Missense_Mutation_p.E342Q|NCOA4_uc010qhe.1_Missense_Mutation_p.E226Q|NCOA4_uc010qhf.1_Missense_Mutation_p.E160Q|NCOA4_uc001jit.2_Missense_Mutation_p.E326Q|NCOA4_uc009xoo.2_Missense_Mutation_p.E326Q	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	326					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						TGAAACCAGTGAGAAGTTTAA	0.478			T	RET	papillary thyroid 								0	0	0	0.001984	0	5	74										C	51584877	G	C	51584877	3	2	63	1	0	0	0	0	1	0	0	0	10231	1291	45	1	1054	1	NCOA4	10	51584877	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	16913185	51584877	83949870	278	18673										
EXOC6	54536	broad.mit.edu	37	chr10	94733956	94733956	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggaccttataaattttttGagaagcatctttcaagtgtt	7	5	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:94733956G>A	uc001kig.2	+	18	1986	c.1920G>A	c.(1918-1920)TTG>TTA	p.L640L	EXOC6_uc010qnr.1_Silent_p.L656L|EXOC6_uc001kie.2_Silent_p.L635L|EXOC6_uc009xub.2_Silent_p.L639L|EXOC6_uc009xuc.2_Silent_p.L537L|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Silent_p.L214L	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	640					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				TAAATTTTTTGAGAAGCATCT	0.284													0	0	0	0.00308	0	5	56										A	94733956	G	A	94733956	2	1	63	1	0	0	0	0	0	0	0	1	5308	1281	45	1		1	EXOC6	10	94733956	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	43149079	94733956	40800791	279	18674										
SORBS1	10580	broad.mit.edu	37	chr10	97096846	97096846	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggagggactggcccttggtGacaaggcgaggtggtcagtg	20	7	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:97096846G>A	uc001kkp.2	-	28	3116	c.3071C>T	c.(3070-3072)TCA>TTA	p.S1024L	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.S978L|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1024					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GGCCCTTGGTGACAAGGCGAG	0.607													0	0	0	0.001855	0	11	26										A	97096846	G	A	97096846	3	1	63	1	0	0	0	0	1	0	0	0	14927	1294	45	1	887	1	SORBS1	10	97096846	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2362890	97096846	38437901	280	18675										
SORBS1	10580	broad.mit.edu	37	chr10	97174257	97174257	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccagcaagcttacggtactCgaaacagctcccgtgaggtc	10	13	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:97174257C>T	uc001kkp.2	-	7	849	c.804G>A	c.(802-804)TCG>TCA	p.S268S	SORBS1_uc001kkl.2_5'UTR|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Silent_p.S268S|SORBS1_uc001kkq.2_Silent_p.S199S|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Silent_p.S236S|SORBS1_uc001kkw.2_Silent_p.S268S|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Silent_p.S466S|SORBS1_uc001kkx.1_Silent_p.S236S	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	268					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		TTACGGTACTCGAAACAGCTC	0.602													0	0	0	0.008291	0	10	63										T	97174257	C	T	97174257	2	4	63	1	0	0	0	0	0	0	0	1	14927	871	31	1		1	SORBS1	10	97174257	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	77411	97174257	38360490	281	18676										
GBF1	8729	broad.mit.edu	37	chr10	104111130	104111130	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtcctgatgaaaatccttcAggtaagcgagagggaaatag	12	6	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:104111130A>T	uc001kux.1	+	5	653	c.413A>T	c.(412-414)CAG>CTG	p.Q138L	GBF1_uc001kuw.2_Missense_Mutation_p.Q138L|GBF1_uc001kuy.1_Missense_Mutation_p.Q138L|GBF1_uc001kuz.1_Missense_Mutation_p.Q138L	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	138					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAAATCCTTCAGGTAAGCGAG	0.517													0	0	0	0.004482	0	8	42										T	104111130	A	T	104111130	3	4	63	1	0	0	0	0	1	0	0	0	6271	202	7	5	427	5	GBF1	10	104111130	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	6936873	104111130	31423617	282	18677										
GBF1	8729	broad.mit.edu	37	chr10	104136749	104136749	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atatgacagcaaagggaaccGcttcaagaagaaatccaaag	9	8	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:104136749G>C	uc001kux.1	+	33	4583	c.4343G>C	c.(4342-4344)CGC>CCC	p.R1448P	GBF1_uc001kuy.1_Missense_Mutation_p.R1448P|GBF1_uc001kuz.1_Missense_Mutation_p.R1449P	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1448					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAAGGGAACCGCTTCAAGAAG	0.517													0	0	0	0.013537	0	12	96										C	104136749	G	C	104136749	3	2	63	1	0	0	0	0	1	0	0	0	6271	1087	38	4	4469	4	GBF1	10	104136749	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	25619	104136749	31397998	283	18678										
CNNM2	54805	broad.mit.edu	37	chr10	104678597	104678597	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acgtggtcccgcatcgccttCaccgagcacgagcggcggcg	14	16	1	0	rs142276906	byFrequency	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:104678597C>T	uc001kwm.2	+	1	484	c.360C>T	c.(358-360)TTC>TTT	p.F120F	CNNM2_uc001kwn.2_Silent_p.F120F|CNNM2_uc001kwl.2_Silent_p.F120F	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	120					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GCATCGCCTTCACCGAGCACG	0.557													0	0	0	0.009096	0	4	25										T	104678597	C	T	104678597	2	4	63	1	0	0	0	0	0	0	0	1	3613	825	29	1		1	CNNM2	10	104678597	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	541848	104678597	30856150	284	18679										
CCDC147	159686	broad.mit.edu	37	chr10	106139900	106139900	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aactacaaggatgaggctcaGaagcagagaaagatcatctt	10	7	3	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:106139900G>A	uc001kyh.2	+	9	1421	c.1287G>A	c.(1285-1287)CAG>CAA	p.Q429Q		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	429	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATGAGGCTCAGAAGCAGAGAA	0.488													0	0	0	0.007413	0	17	68										A	106139900	G	A	106139900	2	1	63	1	0	0	0	0	0	0	0	1	2781	933	33	1		1	CCDC147	10	106139900	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1461303	106139900	29394847	285	18680										
SORCS1	114815	broad.mit.edu	37	chr10	108357148	108357148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggacaaggactcggactcCtggcttcagctcgaagtgta	12	10	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:108357148C>T	uc001kym.2	-	24	3234	c.3226G>A	c.(3226-3228)GGA>AGA	p.G1076R	SORCS1_uc001kyl.2_Missense_Mutation_p.G1076R|SORCS1_uc009xxs.2_Missense_Mutation_p.G1076R|SORCS1_uc001kyn.1_Missense_Mutation_p.G1076R|SORCS1_uc001kyo.2_Missense_Mutation_p.G1076R	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1076	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACTCGGACTCCTGGCTTCAGC	0.502													0	0	0	0.009096	0	3	69										T	108357148	C	T	108357148	3	4	63	1	0	0	0	0	1	0	0	0	14930	690	24	2	526	2	SORCS1	10	108357148	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2217248	108357148	27177599	286	18681										
ZDHHC6	64429	broad.mit.edu	37	chr10	114190585	114190585	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctatttttcttctccccctCtggggcttgatctgtttcag	7	12	6	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:114190585C>T	uc001kzv.2	-	11	1643	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	ZDHHC6_uc001kzw.2_Missense_Mutation_p.E403K	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	407						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		TTCTCCCCCTCTGGGGCTTGA	0.358													0	0	0	0.004482	0	6	74										T	114190585	C	T	114190585	3	4	63	1	0	0	0	0	1	0	0	0	17616	922	32	1	26	1	ZDHHC6	10	114190585	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5833437	114190585	21344162	287	18682										
ATRNL1	26033	broad.mit.edu	37	chr10	117026389	117026389	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttgtaaaaatgctggtccaGggataaaatgtgtttggaat	11	3	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:117026389G>A	uc001lcg.2	+	12	2274	c.1888G>A	c.(1888-1890)GGG>AGG	p.G630R		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	630	PSI 1.|Kelch 6.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGCTGGTCCAGGGATAAAATG	0.363													0	0	0	0.003163	0	12	90										A	117026389	G	A	117026389	3	1	63	1	0	0	0	0	1	0	0	0	1207	1000	35	2	1934	2	ATRNL1	10	117026389	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2835804	117026389	18508358	288	18683										
RGS10	6001	broad.mit.edu	37	chr10	121286922	121286922	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gctgctgctggaactgccatCgctgtcgtggatgtctgcaa	13	11	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:121286922C>G	uc001lee.2	-	1	40	c.40G>C	c.(40-42)GAT>CAT	p.D14H	RGS10_uc001lef.2_Missense_Mutation_p.D8H|RGS10_uc001leg.2_Missense_Mutation_p.D22H	NM_002925	NP_002916	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform b	14					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		GAACTGCCATCGCTGTCGTGG	0.517													0	0	0	0.013537	0	11	69										G	121286922	C	G	121286922	3	3	63	1	0	0	0	0	1	0	0	0	13293	884	31	1	497	1	RGS10	10	121286922	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4260533	121286922	14247825	289	18684										
FAM24A	118670	broad.mit.edu	37	chr10	124671218	124671218	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagcagcttactggttgccgCgatggtgctcctaagtgttg	13	9	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:124671218C>T	uc001lgv.2	+	2	189	c.68C>T	c.(67-69)GCG>GTG	p.A23V		NM_001029888	NP_001025059	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	23						extracellular region				ovary(2)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		CTGGTTGCCGCGATGGTGCTC	0.473													0	0	0	0.01441	0	51	284										T	124671218	C	T	124671218	3	4	63	1	0	0	0	0	1	0	0	0	5547	768	27	2	70	2	FAM24A	10	124671218	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3384296	124671218	10863529	290	18685										
JAKMIP3	282973	broad.mit.edu	37	chr10	133978214	133978214	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagaatagaagctcagaagaGacaaataaaggaactggagg	12	4	1	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:133978214G>C	uc001lkx.3	+	20	2459	c.2459G>C	c.(2458-2460)AGA>ACA	p.R820T	JAKMIP3_uc009yba.1_Missense_Mutation_p.R257T	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GCTCAGAAGAGACAAATAAAG	0.418													0	0	0	0.009096	0	3	26										C	133978214	G	C	133978214	3	2	63	1	0	0	0	0	1	0	0	0	7942	942	33	1	2537	1	JAKMIP3	10	133978214	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	9306996	133978214	1556533	291	18686										
KNDC1	85442	broad.mit.edu	37	chr10	134981812	134981812	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgacgtgaccgggaacacctTtgaggtaagtgcaggtgggg	17	8	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:134981812T>C	uc001llz.1	+	3	357	c.356T>C	c.(355-357)TTT>TCT	p.F119S	KNDC1_uc001lma.1_Missense_Mutation_p.F54S	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	119	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGGAACACCTTTGAGGTAAGT	0.582													0	0	0	0.001855	0	10	73										C	134981812	T	C	134981812	3	2	63	1	0	0	0	0	1	0	0	0	8426	1841	64	5	366	5	KNDC1	10	134981812	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	1003598	134981812	552935	292	18687										
PAOX	196743	broad.mit.edu	37	chr10	135197564	135197564	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttgggaccaacaacaaaatCttcctggagtttgaggagcc	10	9	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:135197564C>T	uc001lmv.2	+	4	1049	c.969C>T	c.(967-969)ATC>ATT	p.I323I	PAOX_uc001lmw.2_Intron|PAOX_uc001lmx.2_Silent_p.I323I|PAOX_uc001lmy.2_Intron|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_Intron|PAOX_uc001lnc.2_Intron	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	461					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		ACAACAAAATCTTCCTGGAGT	0.557													0	0	0	0.009096	0	4	56										T	135197564	C	T	135197564	2	4	63	1	0	0	0	0	0	0	0	1	11423	903	32	1		1	PAOX	10	135197564	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	215752	135197564	337183	293	18688										
SOX6	55553	broad.mit.edu	37	chr11	16071318	16071318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacctaaagaggatcctcttCccaggcttcctccaatgggg	9	13	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:16071318C>T	uc001mme.2	-	11	1490	c.1457G>A	c.(1456-1458)GGA>GAA	p.G486E	SOX6_uc001mmd.2_Missense_Mutation_p.G435E|SOX6_uc001mmf.2_Missense_Mutation_p.G432E|SOX6_uc001mmg.2_Missense_Mutation_p.G473E	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	473					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						GGATCCTCTTCCCAGGCTTCC	0.473													0	0	0	0.008871	0	19	199										T	16071318	C	T	16071318	3	4	63	1	0	0	0	0	1	0	0	0	14955	855	30	1	1134	1	SOX6	11	16071318	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		16071318	118935198	294	18689										
ABCC8	6833	broad.mit.edu	37	chr11	17428510	17428510	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cacttggccagccagtagtcGatggccaccaggaccatgtg	12	13	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:17428510G>T	uc001mnc.2	-	25	3213	c.3087C>A	c.(3085-3087)ATC>ATA	p.I1029I		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1029	ABC transmembrane type-1 2.|Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCCAGTAGTCGATGGCCACCA	0.647													1	0	1.06961e-07	0.00308	1.15426e-07	6	97										T	17428510	G	T	17428510	2	4	63	1	0	0	0	0	0	0	0	1	58	1048	37	3		3	ABCC8	11	17428510	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1357192	17428510	117578006	295	18690										
BDNF	627	broad.mit.edu	37	chr11	27679688	27679688	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacccactcactaatactgtCacacacgctcagctcccctc	3	19	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:27679688C>G	uc010rdu.1	-	2	1275	c.424G>C	c.(424-426)GAC>CAC	p.D142H	BDNFOS_uc001mrm.2_Intron|BDNFOS_uc009yij.2_Intron|BDNFOS_uc009yik.2_Intron|BDNFOS_uc009yil.2_Intron|BDNFOS_uc001mrp.2_Intron|BDNFOS_uc009yim.2_Intron|BDNFOS_uc009yin.2_Intron|BDNFOS_uc009yio.2_Intron|BDNFOS_uc009yip.2_Intron|BDNFOS_uc001mrn.2_Intron|BDNFOS_uc009yiq.2_Intron|BDNFOS_uc001mro.2_Intron|BDNFOS_uc009yir.2_Intron|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_Intron|BDNFOS_uc009yiu.2_Intron|BDNFOS_uc009yiv.2_Intron|BDNFOS_uc009yiw.2_Intron|BDNFOS_uc009yix.2_Intron|BDNFOS_uc009yiy.2_Intron|BDNFOS_uc009yiz.2_Intron|BDNFOS_uc001mrq.3_Intron|BDNFOS_uc001mrr.3_Intron|BDNFOS_uc009yja.2_Intron|BDNFOS_uc009yjb.2_Intron|BDNF_uc010rdv.1_Missense_Mutation_p.D142H|BDNF_uc001mrt.2_Missense_Mutation_p.D157H|BDNF_uc010rdw.1_Missense_Mutation_p.D142H|BDNF_uc009yjd.2_Missense_Mutation_p.D142H|BDNF_uc001mru.2_Missense_Mutation_p.D142H|BDNF_uc010rdx.1_Missense_Mutation_p.D142H|BDNF_uc010rdy.1_Missense_Mutation_p.D142H|BDNF_uc009yjg.2_Missense_Mutation_p.D142H|BDNF_uc009yje.2_Missense_Mutation_p.D224H|BDNF_uc009yjf.2_Missense_Mutation_p.D171H|BDNF_uc001mrv.2_Missense_Mutation_p.D142H|BDNF_uc001mrw.3_Missense_Mutation_p.D142H|BDNF_uc001mrx.2_Missense_Mutation_p.D142H|BDNF_uc001mry.3_Missense_Mutation_p.D142H|BDNF_uc001mrz.3_Missense_Mutation_p.D142H|BDNF_uc001msa.2_Missense_Mutation_p.D150H	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	142						extracellular region	growth factor activity				0						CTAATACTGTCACACACGCTC	0.542													0	0	0	0.008871	0	16	112										G	27679688	C	G	27679688	3	3	63	1	0	0	0	0	1	0	0	0	1394	826	29	1	323	1	BDNF	11	27679688	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	10251178	27679688	107326828	296	18691										
DGKZ	8525	broad.mit.edu	37	chr11	46389235	46389235	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggggagcacatctggttcGagaccaacgtgtccggggac	15	10	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:46389235G>C	uc001ncn.1	+	4	996	c.871G>C	c.(871-873)GAG>CAG	p.E291Q	DGKZ_uc001nch.1_Missense_Mutation_p.E119Q|DGKZ_uc010rgq.1_Missense_Mutation_p.E68Q|DGKZ_uc001ncj.1_Missense_Mutation_p.E68Q|DGKZ_uc010rgr.1_Missense_Mutation_p.E67Q|DGKZ_uc001nck.1_5'UTR|DGKZ_uc001ncl.2_Missense_Mutation_p.E102Q|DGKZ_uc001ncm.2_Missense_Mutation_p.E102Q|DGKZ_uc009yky.1_Missense_Mutation_p.E102Q|DGKZ_uc010rgs.1_Missense_Mutation_p.E102Q|DGKZ_uc001nci.1_Missense_Mutation_p.E68Q	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	291	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CATCTGGTTCGAGACCAACGT	0.657											OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	12	64										C	46389235	G	C	46389235	3	2	63	1	0	0	0	0	1	0	0	0	4474	1059	37	1	1325	1	DGKZ	11	46389235	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	18709547	46389235	88617281	297	18692										
DGKZ	8525	broad.mit.edu	37	chr11	46394037	46394037	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccccgacaagtcttcgacctGagccagggagggcccaagga	13	14	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:46394037G>A	uc001ncn.1	+	12	1676	c.1551G>A	c.(1549-1551)CTG>CTA	p.L517L	DGKZ_uc001nch.1_Silent_p.L345L|DGKZ_uc010rgq.1_Silent_p.L272L|DGKZ_uc001ncj.1_Silent_p.L295L|DGKZ_uc010rgr.1_Silent_p.L294L|DGKZ_uc001nck.1_Silent_p.L107L|DGKZ_uc001ncl.2_Silent_p.L329L|DGKZ_uc001ncm.2_Silent_p.L328L|DGKZ_uc009yky.1_Silent_p.L329L|DGKZ_uc010rgs.1_Silent_p.L306L	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	517	DAGKc.|Mediates interaction with RASGRP1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TCTTCGACCTGAGCCAGGGAG	0.577													0	0	0	0.008291	0	8	90										A	46394037	G	A	46394037	2	1	63	1	0	0	0	0	0	0	0	1	4474	1277	45	1		1	DGKZ	11	46394037	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4802	46394037	88612479	298	18693										
OR4C6	219432	broad.mit.edu	37	chr11	55432656	55432656	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgagaaatggaaaatcaaaAcaatgtgactgaattcattc	7	6	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:55432656A>G	uc001nht.3	+	3	279	c.14A>G	c.(13-15)AAC>AGC	p.N5S	OR4C6_uc010rik.1_Missense_Mutation_p.N5S	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GAAAATCAAAACAATGTGACT	0.373													0	0	0	0.004007	0	12	80										G	55432656	A	G	55432656	3	3	63	1	0	0	0	0	1	0	0	0	11052	43	2	5	16	5	OR4C6	11	55432656	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	9038619	55432656	79573860	299	18694										
OR8H2	390151	broad.mit.edu	37	chr11	55872685	55872685	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatccgcctggacctccagcTtcacactcccatgtattttt	5	15	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:55872685T>G	uc010riy.1	+	1	167	c.167T>G	c.(166-168)CTT>CGT	p.L56R		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GACCTCCAGCTTCACACTCCC	0.428										HNSCC(53;0.14)			0	0	0	0.00632	0	24	264										G	55872685	T	G	55872685	3	3	63	1	0	0	0	0	1	0	0	0	11238	1609	56	5	169	5	OR8H2	11	55872685	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	440029	55872685	79133831	300	18695										
OR9Q1	219956	broad.mit.edu	37	chr11	57947223	57947223	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gctgtgctgctcagttctttCtgttcaccttctttggttcc	8	12	5	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:57947223C>T	uc001nmj.2	+	3	623	c.307C>T	c.(307-309)CTG>TTG	p.L103L		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TCAGTTCTTTCTGTTCACCTT	0.542													0	0	0	0.004482	0	8	64										T	57947223	C	T	57947223	2	4	63	1	0	0	0	0	0	0	0	1	11255	912	32	1		1	OR9Q1	11	57947223	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2074538	57947223	77059293	301	18696										
OR5AN1	390195	broad.mit.edu	37	chr11	59132579	59132579	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaagtgccctagttatcatGatatcctatggctatattgg	9	8	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:59132579G>C	uc010rks.1	+	1	648	c.648G>C	c.(646-648)ATG>ATC	p.M216I		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TAGTTATCATGATATCCTATG	0.418													0	0	0	0.003163	0	11	139										C	59132579	G	C	59132579	3	2	63	1	0	0	0	0	1	0	0	0	11143	1290	45	1	650	1	OR5AN1	11	59132579	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1185356	59132579	75873937	302	18697										
OSBP	5007	broad.mit.edu	37	chr11	59344488	59344488	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgagaagtagtacatgttttCtgcattcttcctaaaagtag	8	6	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:59344488C>T	uc001noc.1	-	13	2551	c.2071G>A	c.(2071-2073)GAA>AAA	p.E691K	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	691					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TACATGTTTTCTGCATTCTTC	0.463													0	0	0	0.004672	0	3	65										T	59344488	C	T	59344488	3	4	63	1	0	0	0	0	1	0	0	0	11273	922	32	1	360	1	OSBP	11	59344488	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	211909	59344488	75662028	303	18698										
VWCE	220001	broad.mit.edu	37	chr11	61034991	61034991	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggaaggtctcgttgttataGaagattctgcctgtgtaggt	14	5	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:61034991G>C	uc001nra.2	-	16	2187	c.1908C>G	c.(1906-1908)TTC>TTG	p.F636L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	636	VWFC 5.					extracellular region	calcium ion binding			ovary(1)	1						CGTTGTTATAGAAGATTCTGC	0.612													0	0	0	0.008291	0	8	71										C	61034991	G	C	61034991	3	2	63	1	0	0	0	0	1	0	0	0	17242	933	33	1	979	1	VWCE	11	61034991	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1690503	61034991	73971525	304	18699										
ASRGL1	80150	broad.mit.edu	37	chr11	62124476	62124476	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagacacctcattgctttctGactgaccaaggcgcagcgca	9	14	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:62124476G>C	uc001nte.3	+	4	635	c.351G>C	c.(349-351)CTG>CTC	p.L117L	ASRGL1_uc001ntf.3_Silent_p.L117L|ASRGL1_uc001ntg.3_5'UTR|ASRGL1_uc001nth.1_RNA	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	117					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	ATTGCTTTCTGACTGACCAAG	0.398													0	0	0	0.000602	0	3	61										C	62124476	G	C	62124476	2	2	63	1	0	0	0	0	0	0	0	1	1060	1277	45	1		1	ASRGL1	11	62124476	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1089485	62124476	72882040	305	18700										
UBXN1	51035	broad.mit.edu	37	chr11	62444099	62444099	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggccacaatgagaacagcaGaaggcacgagtcctgaagat	12	9	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:62444099G>A	uc001nul.1	-	9	989	c.857C>T	c.(856-858)TCT>TTT	p.S286F	UBXN1_uc001nuj.2_3'UTR|UBXN1_uc001num.1_Missense_Mutation_p.S282F|UBXN1_uc001nuk.2_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	286	UBX.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						GAGAACAGCAGAAGGCACGAG	0.483													0	0	0	0.004672	0	3	6										A	62444099	G	A	62444099	3	1	63	1	0	0	0	0	1	0	0	0	16908	957	33	1		1	UBXN1	11	62444099	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	319623	62444099	72562417	306	18701										
NRXN2	9379	broad.mit.edu	37	chr11	64435996	64435996	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggctgcccccaatgtagaaGaagtcatcagagcccagcat	11	12	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:64435996G>C	uc001oar.2	-	9	1717	c.1278C>G	c.(1276-1278)TTC>TTG	p.F426L	NRXN2_uc001oas.2_Missense_Mutation_p.F395L|NRXN2_uc001oaq.2_Missense_Mutation_p.F93L	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CAATGTAGAAGAAGTCATCAG	0.612													0	0	0	0.008291	0	10	119										C	64435996	G	C	64435996	3	2	63	1	0	0	0	0	1	0	0	0	10666	933	33	1	4193	1	NRXN2	11	64435996	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1991897	64435996	70570520	307	18702										
SAPS3	55291	broad.mit.edu	37	chr11	68369379	68369379	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccagtggaaatggaaaccagCactgaacccatggaccctct	9	13	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:68369379C>T	uc001onw.2	+	21	2508	c.2241C>T	c.(2239-2241)AGC>AGT	p.S747S	SAPS3_uc001onv.2_Silent_p.S747S|SAPS3_uc001ony.3_Silent_p.S718S|SAPS3_uc001onx.2_Silent_p.S741S|SAPS3_uc009ysh.2_Silent_p.S667S|SAPS3_uc001onu.2_Silent_p.S667S|SAPS3_uc010rqc.1_Silent_p.S515S|SAPS3_uc010rqd.1_Silent_p.S430S|SAPS3_uc001onz.2_Silent_p.S75S|SAPS3_uc001ooa.2_Silent_p.S197S	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	747					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			TGGAAACCAGCACTGAACCCA	0.517													0	0	0	0.008871	0	16	136										T	68369379	C	T	68369379	2	4	63	1	0	0	0	0	0	0	0	1	13838	709	25	2		2	SAPS3	11	68369379	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3933383	68369379	66637137	308	18703										
SAPS3	55291	broad.mit.edu	37	chr11	68377463	68377463	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggcgaagtgcgcggcgcccAggcctcccagcagcagtccc	14	17	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:68377463A>C	uc001onw.2	+	23	2809	c.2542A>C	c.(2542-2544)AGG>CGG	p.R848R	SAPS3_uc001onv.2_Silent_p.R854R|SAPS3_uc001ony.3_Silent_p.R819R|SAPS3_uc001onx.2_Silent_p.R842R|SAPS3_uc009ysh.2_Silent_p.R768R|SAPS3_uc001onu.2_Silent_p.R768R|SAPS3_uc010rqc.1_Silent_p.R616R|SAPS3_uc010rqd.1_Silent_p.R531R|SAPS3_uc001onz.2_Silent_p.R176R|SAPS3_uc001ooa.2_Silent_p.R304R	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	848					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			CGCGGCGCCCAGGCCTCCCAG	0.612													0	0	0	0.00308	0	7	40										C	68377463	A	C	68377463	2	2	63	1	0	0	0	0	0	0	0	1	13838	179	7	5		5	SAPS3	11	68377463	Silent	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	8084	68377463	66629053	309	18704										
PPFIA1	8500	broad.mit.edu	37	chr11	70202353	70202353	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgaaaaaaatcgtaaacttCaaaaaaagtaagctttgtgt	6	5	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:70202353C>T	uc001opo.2	+	19	2773	c.2575C>T	c.(2575-2577)CAA>TAA	p.Q859*	PPFIA1_uc001opn.1_Nonsense_Mutation_p.Q859*|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	859	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TCGTAAACTTCAAAAAAAGTA	0.393													0	0	0	0.001168	0	5	82										T	70202353	C	T	70202353	4	4	63	1	0	0	0	0	0	1	0	0	12309	827	29	1	2645	1	PPFIA1	11	70202353	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1824890	70202353	64804163	310	18705										
NADSYN1	55191	broad.mit.edu	37	chr11	71166203	71166203	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caagatacaggcttggaccaGagctggaaatatggtgagaa	13	6	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:71166203G>C	uc001oqn.2	+	2	259	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	45	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCTTGGACCAGAGCTGGAAAT	0.473													0	0	0	0.004482	0	8	72										C	71166203	G	C	71166203	3	2	63	1	0	0	0	0	1	0	0	0	10138	943	33	1	139	1	NADSYN1	11	71166203	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	963850	71166203	63840313	311	18706										
PCF11	51585	broad.mit.edu	37	chr11	82877138	82877138	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gttgtctgatatgaacaagaGagatccaagattaaaaaaac	8	5	1	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:82877138G>C	uc001ozx.3	+	5	1544	c.1199G>C	c.(1198-1200)AGA>ACA	p.R400T	PCF11_uc010rsu.1_Missense_Mutation_p.R400T	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	400	Lys-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATGAACAAGAGAGATCCAAGA	0.338													0	0	0	0.009096	0	3	16										C	82877138	G	C	82877138	3	2	63	1	0	0	0	0	1	0	0	0	11573	942	33	1	1217	1	PCF11	11	82877138	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	11710935	82877138	52129378	312	18707										
NOX4	50507	broad.mit.edu	37	chr11	89177304	89177304	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaagacagagaccacccaccTcatctcggtatcttgctgca	8	14	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:89177304T>A	uc001pct.2	-	5	685	c.446A>T	c.(445-447)GAG>GTG	p.E149V	NOX4_uc009yvr.2_Missense_Mutation_p.E124V|NOX4_uc001pcu.2_Missense_Mutation_p.E75V|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Missense_Mutation_p.E149V|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Missense_Mutation_p.E149V|NOX4_uc010rtv.1_Missense_Mutation_p.E125V|NOX4_uc009yvq.2_Missense_Mutation_p.E125V|NOX4_uc009yvs.1_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	149	Extracellular (Potential).|Ferric oxidoreductase.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				ACCACCCACCTCATCTCGGTA	0.448													0	0	0	0.00245	0	13	125										A	89177304	T	A	89177304	3	1	63	1	0	0	0	0	1	0	0	0	10558	1565	54	5	1346	5	NOX4	11	89177304	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	6300166	89177304	45829212	313	18708										
NOX4	50507	broad.mit.edu	37	chr11	89223638	89223638	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttacttacccccaacatctgGtggaggtagtgatactctgg	10	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:89223638G>C	uc001pct.2	-	2	380	c.141C>G	c.(139-141)CAC>CAG	p.H47Q	NOX4_uc009yvr.2_Intron|NOX4_uc001pcu.2_5'UTR|NOX4_uc001pcw.2_Missense_Mutation_p.H47Q|NOX4_uc001pcx.2_Missense_Mutation_p.H47Q|NOX4_uc001pcv.2_Missense_Mutation_p.H47Q|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_5'UTR|NOX4_uc009yvp.2_Missense_Mutation_p.H47Q|NOX4_uc010rtv.1_Missense_Mutation_p.H23Q|NOX4_uc009yvq.2_Missense_Mutation_p.H23Q|NOX4_uc009yvs.1_RNA|NOX4_uc001pcy.2_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	47	Extracellular (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CCAACATCTGGTGGAGGTAGT	0.438													0	0	0	0.00245	0	10	93										C	89223638	G	C	89223638	3	2	63	1	0	0	0	0	1	0	0	0	10558	1252	44	4	1663	4	NOX4	11	89223638	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	46334	89223638	45782878	314	18709										
ARHGAP20	57569	broad.mit.edu	37	chr11	110451669	110451669	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcatgatcccgcagtgggatCtttgtgtacactaaaatgtt	10	8	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:110451669C>T	uc001pkz.1	-	16	2286	c.2001G>A	c.(1999-2001)AAG>AAA	p.K667K	ARHGAP20_uc001pky.1_Silent_p.K644K|ARHGAP20_uc009yyb.1_Silent_p.K631K|ARHGAP20_uc001pla.1_Silent_p.K631K|ARHGAP20_uc001plb.2_Silent_p.K210K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	667					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GCAGTGGGATCTTTGTGTACA	0.507													0	0	0	0.001168	0	3	46										T	110451669	C	T	110451669	2	4	63	1	0	0	0	0	0	0	0	1	870	912	32	1		1	ARHGAP20	11	110451669	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	21228031	110451669	24554847	315	18710										
BTG4	54766	broad.mit.edu	37	chr11	111367977	111367977	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gctgactttaggaatgacacGaggttccttgctacaacttt	9	9	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:111367977G>A	uc001plj.2	-	4	654	c.469C>T	c.(469-471)CGT>TGT	p.R157C	BTG4_uc001plk.2_Missense_Mutation_p.R157C	NM_017589	NP_060059	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	157					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation						0		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		GGAATGACACGAGGTTCCTTG	0.388													0	0	0	0.001984	0	5	125										A	111367977	G	A	111367977	3	1	63	1	0	0	0	0	1	0	0	0	1556	1058	37	1	214	1	BTG4	11	111367977	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	916308	111367977	23638539	316	18711										
CLDN25	644672	broad.mit.edu	37	chr11	113650727	113650727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcaaggcctttgaatccttCttgtctctgccccaggagct	9	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:113650727C>G	uc009yyw.1	+	1	210	c.210C>G	c.(208-210)TTC>TTG	p.F70L		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	70	Extracellular (Potential).					integral to membrane|tight junction	structural molecule activity				0						TTGAATCCTTCTTGTCTCTGC	0.562													0	0	0	0.00308	0	8	90										G	113650727	C	G	113650727	3	3	63	1	0	0	0	0	1	0	0	0	3485	912	32	1	212	1	CLDN25	11	113650727	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2282750	113650727	21355789	317	18712										
SIDT2	51092	broad.mit.edu	37	chr11	117066606	117066606	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	catctggcacttcctctcctCcatcgccatgttcgggtcct	7	17	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:117066606C>A	uc001pqh.1	+	25	2452	c.2411C>A	c.(2410-2412)TCC>TAC	p.S804Y	SIDT2_uc010rxe.1_Missense_Mutation_p.S804Y|SIDT2_uc001pqg.2_Missense_Mutation_p.S825Y|SIDT2_uc001pqi.1_Missense_Mutation_p.S801Y|SIDT2_uc001pqj.1_Missense_Mutation_p.S116Y|uc001pqk.1_RNA	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	804	Helical; (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TTCCTCTCCTCCATCGCCATG	0.612													1	0	8.34094e-07	0.008871	8.96875e-07	17	236										A	117066606	C	A	117066606	3	1	63	1	0	0	0	0	1	0	0	0	14303	855	30	3	2509	3	SIDT2	11	117066606	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3415879	117066606	17939910	318	18713										
USP2	9099	broad.mit.edu	37	chr11	119228516	119228516	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggagaacttctttatacaCcgttttctgcctcggcagcg	9	11	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:119228516C>A	uc001pwm.3	-	10	1747	c.1452G>T	c.(1450-1452)CGG>CGT	p.R484R	USP2_uc001pwl.3_Silent_p.R275R|USP2_uc001pwn.3_Silent_p.R241R	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	484	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		TCTTTATACACCGTTTTCTGC	0.498													1	0	3.11337e-16	0.013726	3.43387e-16	30	309										A	119228516	C	A	119228516	2	1	63	1	0	0	0	0	0	0	0	1	17048	494	18	4		4	USP2	11	119228516	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2161910	119228516	15778000	319	18714										
ARHGEF12	23365	broad.mit.edu	37	chr11	120298895	120298895	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tatgtctcccatcatgacatCtcctcattcacctggagcat	5	14	5	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:120298895C>G	uc001pxl.1	+	8	531	c.524C>G	c.(523-525)TCT>TGT	p.S175C	ARHGEF12_uc009zat.2_Missense_Mutation_p.S156C|ARHGEF12_uc010rzn.1_Missense_Mutation_p.S72C|ARHGEF12_uc009zau.1_Missense_Mutation_p.S72C	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	175					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATCATGACATCTCCTCATTCA	0.498			T	MLL	AML								0	0	0	0.014323	0	16	156										G	120298895	C	G	120298895	3	3	63	1	0	0	0	0	1	0	0	0	897	913	32	1	554	1	ARHGEF12	11	120298895	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1070379	120298895	14707621	320	18715										
UBASH3B	84959	broad.mit.edu	37	chr11	122647792	122647792	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgccccgggagtacgtcctCtacctccgtcccaccggccc	9	21	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:122647792C>T	uc001pyi.3	+	3	636	c.276C>T	c.(274-276)CTC>CTT	p.L92L		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	92						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		AGTACGTCCTCTACCTCCGTC	0.562													0	0	0	0.00308	0	8	65										T	122647792	C	T	122647792	2	4	63	1	0	0	0	0	0	0	0	1	16837	900	32	1		1	UBASH3B	11	122647792	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2348897	122647792	12358724	321	18716										
IQSEC3	440073	broad.mit.edu	37	chr12	248252	248254	+	In_Frame_Del	DEL	GAG	GAG	-													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cccccaaaacagaggaggaaGaggaggaggaggagacggcg							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:248252_248254delGAG	uc001qhw.1	+	1	820_822	c.814_816delGAG	c.(814-816)GAGdel	p.E276del	IQSEC3_uc001qhu.1_In_Frame_Del_p.E276del|IQSEC3_uc001qht.1_In_Frame_Del_p.E361del|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	579	Poly-Glu.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		Agaggaggaagaggaggaggagg	0.586																		2	4	---	---								-	248254	GAG	-	248252	7	5	63	1	0	1	0	1	0	0	0	0	7819	943	33	0	1737	0	IQSEC3	12	248252	In_Frame_Del	DEL	GAG	TCGA-DK-A3IU-01A-11D-A20D-08		248252	133603643	322	18717										
IQSEC3	440073	broad.mit.edu	37	chr12	275008	275008	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agaagttcgtggaggacctgAaggagtccattgctgaggtg	16	6	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:275008A>G	uc001qhw.1	+	8	2020	c.2014A>G	c.(2014-2016)AAG>GAG	p.K672E	IQSEC3_uc001qhu.1_Missense_Mutation_p.K672E	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	975	Potential.|PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GGAGGACCTGAAGGAGTCCAT	0.602													0	0	0	0.00245	0	11	36										G	275008	A	G	275008	3	3	63	1	0	0	0	0	1	0	0	0	7819	247	9	5	2965	5	IQSEC3	12	275008	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	26756	275008	133576887	323	18718										
WNK1	65125	broad.mit.edu	37	chr12	989996	989996	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agtcctatcccctcccatgcCgacagaagtactggctacac	7	16	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:989996C>T	uc001qio.3	+	12	3449	c.2942C>T	c.(2941-2943)CCG>CTG	p.P981L	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	981					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCTCCCATGCCGACAGAAGTA	0.502													0	0	0	0.001168	0	5	321										T	989996	C	T	989996	3	4	63	1	0	0	0	0	1	0	0	0	17374	652	23	2	4490	2	WNK1	12	989996	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	714988	989996	132861899	324	18719										
SCNN1A	6337	broad.mit.edu	37	chr12	6458367	6458367	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccatcgtgagtaaccagcaGagagctggtagctggtcacg	14	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:6458367G>A	uc001qnx.2	-	10	1749	c.1460C>T	c.(1459-1461)TCT>TTT	p.S487F	SCNN1A_uc001qnv.2_Missense_Mutation_p.S187F|SCNN1A_uc001qnw.2_Missense_Mutation_p.S546F|SCNN1A_uc010sfb.1_Missense_Mutation_p.S510F	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	487	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GTAACCAGCAGAGAGCTGGTA	0.572													0	0	0	0.00499	0	15	164										A	6458367	G	A	6458367	3	1	63	1	0	0	0	0	1	0	0	0	13927	942	33	1	565	1	SCNN1A	12	6458367	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5468371	6458367	127393528	325	18720										
ATN1	1822	broad.mit.edu	37	chr12	7044738	7044738	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctcggccacagtctccctCcgatctggatagcttggacg	10	16	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:7044738C>G	uc001qrw.1	+	5	545	c.308C>G	c.(307-309)TCC>TGC	p.S103C	ATN1_uc001qrx.1_Missense_Mutation_p.S103C|ATN1_uc001qry.1_Missense_Mutation_p.S102C	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	103					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CAGTCTCCCTCCGATCTGGAT	0.532													0	0	0	0.008291	0	10	30										G	7044738	C	G	7044738	3	3	63	1	0	0	0	0	1	0	0	0	1111	855	30	1	322	1	ATN1	12	7044738	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	586371	7044738	126807157	326	18721										
RECQL	5965	broad.mit.edu	37	chr12	21624538	21624538	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctgcctgcttcaggatcttGattagatctctgcagtactc	8	11	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:21624538G>A	uc001rex.2	-	14	1839	c.1491C>T	c.(1489-1491)ATC>ATT	p.I497I	RECQL_uc001rey.2_Silent_p.I497I	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	497					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TCAGGATCTTGATTAGATCTC	0.383								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.001984	0	5	89										A	21624538	G	A	21624538	2	1	63	1	0	0	0	0	0	0	0	1	13201	1280	45	1		1	RECQL	12	21624538	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	14579800	21624538	112227357	327	18722										
ABCC9	10060	broad.mit.edu	37	chr12	21995253	21995253	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgctgttttacttacttagaGgcaacccgaaagtatttctg	8	8	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:21995253G>A	uc001rfi.1	-	27	3488	c.3468C>T	c.(3466-3468)GCC>GCT	p.A1156A	ABCC9_uc001rfh.2_Silent_p.A1156A|ABCC9_uc001rfj.1_Silent_p.A1120A	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1156	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTTACTTAGAGGCAACCCGAA	0.308													0	0	0	0.013537	0	10	25										A	21995253	G	A	21995253	2	1	63	1	0	0	0	0	0	0	0	1	59	987	35	2		2	ABCC9	12	21995253	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	370715	21995253	111856642	328	18723										
KIAA0528	9847	broad.mit.edu	37	chr12	22627716	22627716	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagcatcttttttcccatgtGaaaggtctaattctgtaact	6	8	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:22627716G>C	uc001rfq.2	-	16	2240	c.2012C>G	c.(2011-2013)TCA>TGA	p.S671*	KIAA0528_uc010sir.1_Nonsense_Mutation_p.S486*|KIAA0528_uc010sis.1_Nonsense_Mutation_p.S671*|KIAA0528_uc010sit.1_Nonsense_Mutation_p.S673*|KIAA0528_uc010siu.1_Nonsense_Mutation_p.S671*|KIAA0528_uc001rfr.2_Nonsense_Mutation_p.S662*	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	671							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TTTCCCATGTGAAAGGTCTAA	0.383													0	0	0	0.010729	0	9	98										C	22627716	G	C	22627716	4	2	63	1	0	0	0	0	0	1	0	0	8182	1294	45	1	1030	1	KIAA0528	12	22627716	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	632463	22627716	111224179	329	18724										
TMTC1	83857	broad.mit.edu	37	chr12	29736357	29736357	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacctgaatagggactctctTgacagccaaatttcattctg	7	10	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:29736357T>A	uc001rjb.2	-	8	1551	c.1077A>T	c.(1075-1077)TCA>TCT	p.S359S	TMTC1_uc001riz.2_Silent_p.S116S|TMTC1_uc001rja.2_Silent_p.S203S|TMTC1_uc001rjc.1_Silent_p.S421S	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	467						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGGACTCTCTTGACAGCCAAA	0.398													0	0	0	0.001168	0	4	55										A	29736357	T	A	29736357	2	1	63	1	0	0	0	0	0	0	0	1	16257	1799	63	5		5	TMTC1	12	29736357	Silent	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	7108641	29736357	104115538	330	18725										
PKP2	5318	broad.mit.edu	37	chr12	32974300	32974300	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caatactcactggtccacttCcggccgtgaggttctgcaga	10	13	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:32974300C>T	uc001rlj.3	-	10	2250	c.2135G>A	c.(2134-2136)GGA>GAA	p.G712E	PKP2_uc001rlk.3_Missense_Mutation_p.G668E|PKP2_uc010skj.1_Missense_Mutation_p.G665E	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	712					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGGTCCACTTCCGGCCGTGAG	0.423													0	0	0	0.004482	0	7	40										T	32974300	C	T	32974300	3	4	63	1	0	0	0	0	1	0	0	0	11985	855	30	1	530	1	PKP2	12	32974300	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3237943	32974300	100877595	331	18726										
TMEM106C	79022	broad.mit.edu	37	chr12	48361983	48361983	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggagacacatcactatgtgGattgtggaggaaattccaca	11	7	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:48361983G>T	uc001rqp.2	+	8	839	c.724G>T	c.(724-726)GAT>TAT	p.D242Y	TMEM106C_uc001rqo.2_Missense_Mutation_p.D223Y|TMEM106C_uc001rqr.2_Missense_Mutation_p.D242Y|TMEM106C_uc001rqq.2_Missense_Mutation_p.D223Y	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	242						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TCACTATGTGGATTGTGGAGG	0.428													1	0	4.36969e-10	0.001855	4.76694e-10	10	70										T	48361983	G	T	48361983	3	4	63	1	0	0	0	0	1	0	0	0	16019	1174	41	3	750	3	TMEM106C	12	48361983	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	15387683	48361983	85489912	332	18727										
ADCY6	112	broad.mit.edu	37	chr12	49177157	49177157	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acgcttctgcccattgcgttCaccccaggctgttttccgtt	8	15	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:49177157C>T	uc001rsh.3	-	1	721	c.61G>A	c.(61-63)GAA>AAA	p.E21K	ADCY6_uc001rsj.3_Missense_Mutation_p.E21K|ADCY6_uc001rsi.3_Missense_Mutation_p.E21K	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	21	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CCATTGCGTTCACCCCAGGCT	0.582													0	0	0	0.001168	0	6	36										T	49177157	C	T	49177157	3	4	63	1	0	0	0	0	1	0	0	0	298	835	29	1	3529	1	ADCY6	12	49177157	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	815174	49177157	84674738	333	18728										
MLL2	8085	broad.mit.edu	37	chr12	49444684	49444684	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttacctggtggcatcagctGaggcgacaaggatggctccc	13	12	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:49444684G>A	uc001rta.3	-	10	2782	c.2782C>T	c.(2782-2784)CAG>TAG	p.Q928*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	928	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCATCAGCTGAGGCGACAAG	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004007	0	12	71										A	49444684	G	A	49444684	4	1	63	1	0	0	0	0	0	1	0	0	9621	1299	45	1	14011	1	MLL2	12	49444684	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	267527	49444684	84407211	334	18729										
TFCP2	7024	broad.mit.edu	37	chr12	51512521	51512521	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcaggaggcaaactcgactCttcttgcttaaaaatgggca	9	9	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:51512521C>T	uc001rxw.2	-	2	616	c.157G>A	c.(157-159)GAG>AAG	p.E53K	TFCP2_uc001rxv.1_Missense_Mutation_p.E53K|TFCP2_uc009zlx.1_Missense_Mutation_p.E53K|TFCP2_uc001rxx.2_Missense_Mutation_p.E53K|TFCP2_uc009zly.1_5'UTR	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	53					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAACTCGACTCTTCTTGCTTA	0.398													0	0	0	0.001168	0	6	115										T	51512521	C	T	51512521	3	4	63	1	0	0	0	0	1	0	0	0	15792	922	32	1	1407	1	TFCP2	12	51512521	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2067837	51512521	82339374	335	18730										
MFSD5	84975	broad.mit.edu	37	chr12	53647579	53647579	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgctgtcccttgctgtgctCatcgtcgtcttctctctctt	7	15	4	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:53647579C>T	uc001sci.1	+	2	1151	c.960C>T	c.(958-960)CTC>CTT	p.L320L	MFSD5_uc001sch.1_Silent_p.L427L	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	320	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						TTGCTGTGCTCATCGTCGTCT	0.547													0	0	0	0.001984	0	6	75										T	53647579	C	T	53647579	2	4	63	1	0	0	0	0	0	0	0	1	9534	813	29	1		1	MFSD5	12	53647579	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2135058	53647579	80204316	336	18731										
HOXC4	3221	broad.mit.edu	37	chr12	54447857	54447857	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gattccagcatcaccaccagGagctgtacccaccaccgcct	7	18	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:54447857G>A	uc001seu.2	+	3	831	c.151G>A	c.(151-153)GAG>AAG	p.E51K	HOXC4_uc001sex.2_Missense_Mutation_p.E51K	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCACCACCAGGAGCTGTACCC	0.607													0	0	0	0.00499	0	16	213										A	54447857	G	A	54447857	3	1	63	1	0	0	0	0	1	0	0	0	7313	1175	41	1	153	1	HOXC4	12	54447857	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	800278	54447857	79404038	337	18732										
OR6C76	390326	broad.mit.edu	37	chr12	55820661	55820661	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttactcttatatccactttGatattagtaattctctccta	2	9	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:55820661G>C	uc010spm.1	+	1	624	c.624G>C	c.(622-624)TTG>TTC	p.L208F		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TATCCACTTTGATATTAGTAA	0.398													0	0	0	0.000602	0	5	25										C	55820661	G	C	55820661	3	2	63	1	0	0	0	0	1	0	0	0	11200	1281	45	1	626	1	OR6C76	12	55820661	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1372804	55820661	78031234	338	18733										
DNAJC14	85406	broad.mit.edu	37	chr12	56215782	56215782	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caacgttggaagggcctcctCactttcttccgccgcttagg	10	14	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:56215782C>G	uc001shx.1	-	7	2292	c.2088G>C	c.(2086-2088)GTG>GTC	p.V696V	DNAJC14_uc001shu.1_Intron|DNAJC14_uc009zob.1_Silent_p.V696V	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	696					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						AGGGCCTCCTCACTTTCTTCC	0.542													0	0	0	0.007413	0	14	128										G	56215782	C	G	56215782	2	3	63	1	0	0	0	0	0	0	0	1	4633	813	29	1		1	DNAJC14	12	56215782	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	395121	56215782	77636113	339	18734										
TIMELESS	8914	broad.mit.edu	37	chr12	56822054	56822054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcccacggctccgacagaatCgctccaacattttgaggaag	9	13	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:56822054C>T	uc001slf.2	-	13	1712	c.1544G>A	c.(1543-1545)CGA>CAA	p.R515Q	TIMELESS_uc001slg.2_Missense_Mutation_p.R514Q	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	515					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CCGACAGAATCGCTCCAACAT	0.542													0	0	0	0.007413	0	13	58										T	56822054	C	T	56822054	3	4	63	1	0	0	0	0	1	0	0	0	15901	884	31	1	2150	1	TIMELESS	12	56822054	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	606272	56822054	77029841	340	18735										
TIMELESS	8914	broad.mit.edu	37	chr12	56822689	56822689	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcgtgcccaggaggcagcttCcttgcggtcagtcagcatca	13	13	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:56822689C>T	uc001slf.2	-	11	1450	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	TIMELESS_uc001slg.2_Missense_Mutation_p.E427K	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	428					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GAGGCAGCTTCCTTGCGGTCA	0.532													0	0	0	0.00499	0	12	38										T	56822689	C	T	56822689	3	4	63	1	0	0	0	0	1	0	0	0	15901	864	30	1	2420	1	TIMELESS	12	56822689	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	635	56822689	77029206	341	18736										
ZFC3H1	196441	broad.mit.edu	37	chr12	72022749	72022749	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcactactgaagctattatCtgaaataggttttctccaaa	5	8	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:72022749C>G	uc001swo.2	-	20	4254	c.3895G>C	c.(3895-3897)GAT>CAT	p.D1299H		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1299					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						AAGCTATTATCTGAAATAGGT	0.328													0	0	0	0.004672	0	3	42										G	72022749	C	G	72022749	3	3	63	1	0	0	0	0	1	0	0	0	17630	913	32	1	2138	1	ZFC3H1	12	72022749	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	15200060	72022749	61829146	342	18737										
ZFC3H1	196441	broad.mit.edu	37	chr12	72057344	72057344	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caagctccccttcttccttcGgcgagaggccactggaggcc	11	16	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:72057344G>A	uc001swo.2	-	1	406	c.47C>T	c.(46-48)CCG>CTG	p.P16L	ZFC3H1_uc010sts.1_Missense_Mutation_p.P16L|ZFC3H1_uc001swp.2_Missense_Mutation_p.P16L|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	16					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTCTTCCTTCGGCGAGAGGCC	0.652											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	13	181										A	72057344	G	A	72057344	3	1	63	1	0	0	0	0	1	0	0	0	17630	1116	39	2	6062	2	ZFC3H1	12	72057344	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	34595	72057344	61794551	343	18738										
TMTC2	160335	broad.mit.edu	37	chr12	83455601	83455601	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tatgatctggcagccaggctGaggcctaatgtaagtacttc	11	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:83455601G>A	uc001szt.2	+	11	2754	c.2322G>A	c.(2320-2322)CTG>CTA	p.L774L	TMTC2_uc010suk.1_Silent_p.L529L	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	774	TPR 9.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CAGCCAGGCTGAGGCCTAATG	0.353													0	0	0	0.001855	0	11	121										A	83455601	G	A	83455601	2	1	63	1	0	0	0	0	0	0	0	1	16258	1277	45	1		1	TMTC2	12	83455601	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	11398257	83455601	50396294	344	18739										
TMTC3	160418	broad.mit.edu	37	chr12	88570051	88570051	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggaaaatgaaaagaactttGagagagctttgaaatacttc	9	4	0	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:88570051G>C	uc001tau.2	+	10	1607	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	463	TPR 2.					integral to membrane	binding			skin(1)	1						AAAGAACTTTGAGAGAGCTTT	0.289													0	0	0	0.000602	0	4	32										C	88570051	G	C	88570051	3	2	63	1	0	0	0	0	1	0	0	0	16259	1291	45	1	1421	1	TMTC3	12	88570051	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5114450	88570051	45281844	345	18740										
NUDT4	11163	broad.mit.edu	37	chr12	93792607	93792607	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagtcactgaaatattagaaGattgggaagattctgttaat	9	4	2	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:93792607G>C	uc001tcm.2	+	4	714	c.316G>C	c.(316-318)GAT>CAT	p.D106H	NUDT4_uc010sup.1_Missense_Mutation_p.D106H|NUDT4_uc001tcn.2_Missense_Mutation_p.D54H|NUDT4_uc010suq.1_Missense_Mutation_p.D55H|NUDT4_uc001tco.2_Missense_Mutation_p.D54H	NM_019094	NP_061967	Q9NZJ9	NUDT4_HUMAN	nudix-type motif 4 isoform alpha	106	Nudix hydrolase.				calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0						AATATTAGAAGATTGGGAAGA	0.323													0	0	0	0.004672	0	3	26										C	93792607	G	C	93792607	3	2	63	1	0	0	0	0	1	0	0	0	10741	942	33	1	333	1	NUDT4	12	93792607	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5222556	93792607	40059288	346	18741										
TMCC3	57458	broad.mit.edu	37	chr12	94975783	94975783	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatcaggttggcaaactctcTggacttattgaaaacgaaca	9	8	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:94975783T>C	uc001tdj.2	-	2	728	c.610A>G	c.(610-612)AGA>GGA	p.R204G	TMCC3_uc001tdi.2_Missense_Mutation_p.R173G	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	204						integral to membrane				ovary(1)|skin(1)	2						GCAAACTCTCTGGACTTATTG	0.512													0	0	0	0.004007	0	13	82										C	94975783	T	C	94975783	3	2	63	1	0	0	0	0	1	0	0	0	15991	1588	55	5	835	5	TMCC3	12	94975783	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	1183176	94975783	38876112	347	18742										
HAL	3034	broad.mit.edu	37	chr12	96389601	96389601	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatatagcgcctcacggcctCccggcccagccagcccacag	10	19	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:96389601C>T	uc001tem.1	-	2	385	c.88G>A	c.(88-90)GAG>AAG	p.E30K	HAL_uc009zti.1_RNA|HAL_uc010suw.1_5'UTR|HAL_uc010sux.1_Missense_Mutation_p.E30K	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	30					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CTCACGGCCTCCCGGCCCAGC	0.652													0	0	0	0.00308	0	7	33										T	96389601	C	T	96389601	3	4	63	1	0	0	0	0	1	0	0	0	6947	864	30	1	1965	1	HAL	12	96389601	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1413818	96389601	37462294	348	18743										
NEDD1	121441	broad.mit.edu	37	chr12	97345758	97345758	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttctttgctggaaagatactCagtgaatgaaggtttagtgg	12	4	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:97345758C>G	uc001teu.3	+	16	2249	c.1910C>G	c.(1909-1911)TCA>TGA	p.S637*	NEDD1_uc001tev.3_Nonsense_Mutation_p.S637*|NEDD1_uc010svc.1_Nonsense_Mutation_p.S548*|NEDD1_uc001tew.2_Nonsense_Mutation_p.S644*|NEDD1_uc001tex.2_Nonsense_Mutation_p.S548*	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	637					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GAAAGATACTCAGTGAATGAA	0.318													0	0	0	0.001168	0	6	60										G	97345758	C	G	97345758	4	3	63	1	0	0	0	0	0	1	0	0	10309	838	29	1	1989	1	NEDD1	12	97345758	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	956157	97345758	36506137	349	18744										
ANKS1B	56899	broad.mit.edu	37	chr12	99640173	99640173	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcattggaaggataggcaatGagatcagaatcagatttaga	11	4	3	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:99640173G>C	uc001tge.1	-	13	2643	c.2226C>G	c.(2224-2226)CTC>CTG	p.L742L	ANKS1B_uc001tgf.1_Silent_p.L322L|ANKS1B_uc001tgk.2_Silent_p.L39L|ANKS1B_uc009ztt.1_Silent_p.L708L	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	742						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GATAGGCAATGAGATCAGAAT	0.413													0	0	0	0.010729	0	11	45										C	99640173	G	C	99640173	2	2	63	1	0	0	0	0	0	0	0	1	689	1277	45	1		1	ANKS1B	12	99640173	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2294415	99640173	34211722	350	18745										
C12orf48	55010	broad.mit.edu	37	chr12	102547708	102547708	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggtgatgaaactgatctttCtataccaacatcaccaacaa	5	10	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:102547708C>G	uc001tjf.2	+	4	561	c.449C>G	c.(448-450)TCT>TGT	p.S150C	C12orf48_uc001tje.2_Missense_Mutation_p.S69C|C12orf48_uc001tjg.2_Missense_Mutation_p.S69C|C12orf48_uc010swa.1_Missense_Mutation_p.S227C|C12orf48_uc001tjh.2_Missense_Mutation_p.S69C|C12orf48_uc010swb.1_Intron|C12orf48_uc001tji.2_Missense_Mutation_p.S154C|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_5'UTR|C12orf48_uc001tjk.2_Missense_Mutation_p.S150C|C12orf48_uc009zud.2_Missense_Mutation_p.S150C	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	150					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						ACTGATCTTTCTATACCAACA	0.338													0	0	0	0.003163	0	11	76										G	102547708	C	G	102547708	3	3	63	1	0	0	0	0	1	0	0	0	1692	913	32	1	212	1	C12orf48	12	102547708	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2907535	102547708	31304187	351	18746										
NT5DC3	51559	broad.mit.edu	37	chr12	104182660	104182660	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caacttatggattttatcccAgagtaagacacctttctcat	5	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:104182660A>T	uc010swe.1	-	10	1098	c.1057T>A	c.(1057-1059)TGG>AGG	p.W353R		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	353							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						ATTTTATCCCAGAGTAAGACA	0.403													0	0	0	0.011902	0	35	196										T	104182660	A	T	104182660	3	4	63	1	0	0	0	0	1	0	0	0	10692	188	7	5	609	5	NT5DC3	12	104182660	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	1634952	104182660	29669235	352	18747										
SLC41A2	84102	broad.mit.edu	37	chr12	105238268	105238268	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acctgtaacacagcgccaaaTaaatacactactatgaagat	5	10	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:105238268T>C	uc001tla.2	-	9	1685	c.1518A>G	c.(1516-1518)TTA>TTG	p.L506L		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	506	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAGCGCCAAATAAATACACTA	0.318													0	0	0	0.00245	0	14	85										C	105238268	T	C	105238268	2	2	63	1	0	0	0	0	0	0	0	1	14630	1403	49	5		5	SLC41A2	12	105238268	Silent	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	1055608	105238268	28613627	353	18748										
CCDC64	92558	broad.mit.edu	37	chr12	120510439	120510439	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggacgagtcttcagaaacctCgtccgccaaggatgtgccag	12	12	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:120510439C>T	uc001txl.1	+	6	1239	c.1214C>T	c.(1213-1215)TCG>TTG	p.S405L	CCDC64_uc001txk.2_Missense_Mutation_p.S405L|CCDC64_uc009zwv.1_Intron|CCDC64_uc010sze.1_Intron|CCDC64_uc010szf.1_Missense_Mutation_p.S54L	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	405					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCAGAAACCTCGTCCGCCAAG	0.567													0	0	0	0.006214	0	8	62										T	120510439	C	T	120510439	3	4	63	1	0	0	0	0	1	0	0	0	2835	893	31	1	1236	1	CCDC64	12	120510439	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	15272171	120510439	13341456	354	18749										
VPS37B	79720	broad.mit.edu	37	chr12	123380553	123380553	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctcgtcctccagcagctcGttgagctgcaccagcgacag	10	17	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:123380553G>C	uc001udl.2	-	1	160	c.57C>G	c.(55-57)AAC>AAG	p.N19K		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	19					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		CCAGCAGCTCGTTGAGCTGCA	0.716													0	0	0	0.001168	0	3	47										C	123380553	G	C	123380553	3	2	63	1	0	0	0	0	1	0	0	0	17203	1136	40	4	816	4	VPS37B	12	123380553	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2870114	123380553	10471342	355	18750										
GPR133	283383	broad.mit.edu	37	chr12	131487836	131487836	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggtcaccgtggagggctcctCtgccatggcaggtagctgtc	15	12	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:131487836C>A	uc001uit.3	+	10	1692	c.1133C>A	c.(1132-1134)TCT>TAT	p.S378Y	GPR133_uc010tbm.1_Missense_Mutation_p.S410Y	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	378	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGGGCTCCTCTGCCATGGCA	0.602													1	0	0.00116845	0.001168	0.00119841	4	44										A	131487836	C	A	131487836	3	1	63	1	0	0	0	0	1	0	0	0	6643	913	32	3	1171	3	GPR133	12	131487836	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	8107283	131487836	2364059	356	18751										
CHFR	55743	broad.mit.edu	37	chr12	133433091	133433092	+	Nonsense_Mutation	DNP	CC	CC	AA													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	actgtcaacgtctgacagctCcagcaggtcctctgaactcc							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:133433091_133433092CC>AA	uc001ulf.2	-	10	1311_1312	c.1227_1228GG>TT	c.(1225-1230)CTGGAG>CTTTAG	p.E410*	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Nonsense_Mutation_p.E398*|CHFR_uc010tbs.1_Nonsense_Mutation_p.E410*|CHFR_uc001uld.2_Nonsense_Mutation_p.E369*|CHFR_uc010tbt.1_Nonsense_Mutation_p.E318*	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	410					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCTGACAGCTCCAGCAGGTCCT	0.505													0	0	0	0.004672	0	29	99										AA	133433092	CC	AA	133433091	4	1	63	1	0	0	0	0	0	1	0	0	3337	864	30	3	802	3	CHFR	12	133433091	Nonsense_Mutation	DNP	CC	TCGA-DK-A3IU-01A-11D-A20D-08	1945255	133433091	418804	357	18752										
RNF17	56163	broad.mit.edu	37	chr13	25419163	25419163	+	Frame_Shift_Del	DEL	A	A	-													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgtttaagaaaacttgaagAaaatctaaagacaatgggaa							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:25419163delA	uc001upr.2	+	22	3088	c.3047delA	c.(3046-3048)GAAfs	p.E1016fs	RNF17_uc010tdd.1_Frame_Shift_Del_p.E875fs|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Frame_Shift_Del_p.E1016fs|RNF17_uc001ups.2_Frame_Shift_Del_p.E955fs|RNF17_uc010aac.2_Frame_Shift_Del_p.E214fs|RNF17_uc010aad.2_Frame_Shift_Del_p.E68fs	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1016	Tudor 2.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AAACTTGAAGAAAATCTAAAG	0.303																		18	118	---	---								-	25419163	A	-	25419163	7	5	63	1	0	1	0	1	0	0	0	0	13461	246	9	0	3133	0	RNF17	13	25419163	Frame_Shift_Del	DEL	A	TCGA-DK-A3IU-01A-11D-A20D-08		25419163	89750715	358	18753										
CENPJ	55835	broad.mit.edu	37	chr13	25473722	25473722	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcgaagtctgcaatttctttCctaaaatgaccaaactatgt	5	9	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:25473722C>A	uc001upt.3	-	9	3079	c.2826G>T	c.(2824-2826)AGG>AGT	p.R942S	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'UTR	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	942					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CAATTTCTTTCCTAAAATGAC	0.403													1	0	0.000442599	0.006214	0.000456288	7	29										A	25473722	C	A	25473722	3	1	63	1	0	0	0	0	1	0	0	0	3234	869	30	3	1226	3	CENPJ	13	25473722	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	54559	25473722	89696156	359	18754										
CDK8	1024	broad.mit.edu	37	chr13	26828880	26828880	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggccgaggcacttatggtcaCgtctacaaagccaagaggaa	12	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:26828880C>T	uc001uqr.1	+	1	128	c.102C>T	c.(100-102)CAC>CAT	p.H34H	CDK8_uc001uqs.1_Silent_p.H34H|CDK8_uc001uqt.1_Translation_Start_Site	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	34	Protein kinase.|ATP (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CTTATGGTCACGTCTACAAAG	0.607													0	0	0	0.00308	0	7	28										T	26828880	C	T	26828880	2	4	63	1	0	0	0	0	0	0	0	1	3150	535	19	2		2	CDK8	13	26828880	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1355158	26828880	88340998	360	18755										
FRY	10129	broad.mit.edu	37	chr13	32826017	32826017	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttgtgtttcttttccagaaGagaacaaaagagaagttggt	10	5	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:32826017G>A	uc001utx.2	+	50	7669	c.7173G>A	c.(7171-7173)AAG>AAA	p.K2391K	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_5'Flank	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTTTCCAGAAGAGAACAAAAG	0.323													0	0	0	0.003163	0	10	139										A	32826017	G	A	32826017	2	1	63	1	0	0	0	0	0	0	0	1	6063	933	33	1		1	FRY	13	32826017	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5997137	32826017	82343861	361	18756										
DIAPH3	81624	broad.mit.edu	37	chr13	60545102	60545102	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tcctccaaggaatcccagggGaggtggtggaggcacaggac	16	10	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:60545102G>T	uc001vht.2	-	16	2062	c.1843C>A	c.(1843-1845)CCC>ACC	p.P615T	DIAPH3_uc001vhu.2_Missense_Mutation_p.P352T|DIAPH3_uc001vhv.2_Missense_Mutation_p.P193T	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	615	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AATCCCAGGGGAGGTGGTGGA	0.542													1	0	6.31075e-24	0.01441	6.98607e-24	40	113										T	60545102	G	T	60545102	3	4	63	1	0	0	0	0	1	0	0	0	4520	1174	41	3	1810	3	DIAPH3	13	60545102	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	27719085	60545102	54624776	362	18757										
KLF5	688	broad.mit.edu	37	chr13	73636090	73636090	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtatagacgagacagtgcctCagtcgtagaccagttcttca	10	10	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:73636090C>T	uc001vje.2	+	2	677	c.353C>T	c.(352-354)TCA>TTA	p.S118L	KLF5_uc001vjd.2_Missense_Mutation_p.S27L	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	118					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GACAGTGCCTCAGTCGTAGAC	0.443													0	0	0	0.007413	0	17	243										T	73636090	C	T	73636090	3	4	63	1	0	0	0	0	1	0	0	0	8349	838	29	1	359	1	KLF5	13	73636090	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	13090988	73636090	41533788	363	18758										
KLF5	688	broad.mit.edu	37	chr13	73636396	73636396	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacaccagatcttcatctttCtgtccctacccagcagggcc	6	16	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:73636396C>T	uc001vje.2	+	2	983	c.659C>T	c.(658-660)TCT>TTT	p.S220F	KLF5_uc001vjd.2_Missense_Mutation_p.S129F	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	220					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CTTCATCTTTCTGTCCCTACC	0.463													0	0	0	0.009096	0	4	93										T	73636396	C	T	73636396	3	4	63	1	0	0	0	0	1	0	0	0	8349	913	32	1	665	1	KLF5	13	73636396	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	306	73636396	41533482	364	18759										
LMO7	4008	broad.mit.edu	37	chr13	76335156	76335156	+	Translation_Start_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggagatctacaggatttatCaaatcgagtcactgtcaagt	9	7	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:76335156C>G	uc001vjv.2	+	1	360	c.-400C>G	c.(-402--398)ATCAA>ATGAA		LMO7_uc010thv.1_Nonsense_Mutation_p.S152*|LMO7_uc001vjt.1_Nonsense_Mutation_p.S100*|LMO7_uc010thw.1_Nonsense_Mutation_p.S61*|LMO7_uc001vju.1_RNA	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2							cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CAGGATTTATCAAATCGAGTC	0.333													0	0	0	0.007413	0	15	34										G	76335156	C	G	76335156	1	3	63	1	0	0	0	0	0	0	0	0	8855	838	29	1		1	LMO7	13	76335156	Translation_Start_Site	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2698760	76335156	38834722	365	18760										
NALCN	259232	broad.mit.edu	37	chr13	102029397	102029397	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctgatcaactatatcagcaAtttcaaacacctacaaatta	2	10	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:102029397A>C	uc001vox.1	-	5	575	c.386T>G	c.(385-387)ATT>AGT	p.I129S	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.I129S|NALCN_uc001vpa.2_Missense_Mutation_p.I129S	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	129	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATATCAGCAATTTCAAACAC	0.403													0	0	0	0.000602	0	5	83										C	102029397	A	C	102029397	3	2	63	1	0	0	0	0	1	0	0	0	10148	101	4	5	4990	5	NALCN	13	102029397	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	25694241	102029397	13140481	366	18761										
MYO16	23026	broad.mit.edu	37	chr13	109661365	109661365	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaacagcatattctcctggtAaccagaatggagttttggac	9	8	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:109661365A>G	uc001vqt.1	+	22	2623	c.2497A>G	c.(2497-2499)AAC>GAC	p.N833D	MYO16_uc010agk.1_Missense_Mutation_p.N855D|MYO16_uc001vqu.1_Missense_Mutation_p.N633D|MYO16_uc010tjh.1_Missense_Mutation_p.N345D	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	833					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCTCCTGGTAACCAGAATGG	0.353													0	0	0	0.013537	0	11	128										G	109661365	A	G	109661365	3	3	63	1	0	0	0	0	1	0	0	0	10064	362	13	5	2579	5	MYO16	13	109661365	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	7631968	109661365	5508513	367	18762										
TMCO3	55002	broad.mit.edu	37	chr13	114154315	114154315	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagttctgagggtggaggaaGaagaggccaattctaagcaa	14	6	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:114154315G>A	uc001vtu.3	+	4	1028	c.667G>A	c.(667-669)GAA>AAA	p.E223K	TMCO3_uc001vtt.3_Missense_Mutation_p.E223K	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	223	Poly-Glu.			E -> G (in Ref. 2; BAA91295).		integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GGTGGAGGAAGAAGAGGCCAA	0.383													0	0	0	0.000602	0	4	68										A	114154315	G	A	114154315	3	1	63	1	0	0	0	0	1	0	0	0	15994	943	33	1	677	1	TMCO3	13	114154315	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4492950	114154315	1015563	368	18763										
CHD8	57680	broad.mit.edu	37	chr14	21897300	21897300	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atctggattttttgctgtggCtgctgcacctgcagctggat	12	9	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:21897300C>T	uc001was.1	-	3	295	c.201G>A	c.(199-201)CAG>CAA	p.Q67Q	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	346	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTTGCTGTGGCTGCTGCACCT	0.567													0	0	0	0.006214	0	9	87										T	21897300	C	T	21897300	2	4	63	1	0	0	0	0	0	0	0	1	3331	796	28	2		2	CHD8	14	21897300	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		21897300	85452240	369	18764										
MMP14	4323	broad.mit.edu	37	chr14	23306101	23306101	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggcaccgcgctcgcctccctCggctcggcccaaagcagcag	12	19	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:23306101C>T	uc001whc.2	+	1	309	c.75C>T	c.(73-75)CTC>CTT	p.L25L		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	25						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TCGCCTCCCTCGGCTCGGCCC	0.726											OREG0022586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	47										T	23306101	C	T	23306101	2	4	63	1	0	0	0	0	0	0	0	1	9653	871	31	1		1	MMP14	14	23306101	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1408801	23306101	84043439	370	18765										
RNF31	55072	broad.mit.edu	37	chr14	24617902	24617902	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agctgttggaagacaaggttGaagatgatgtaaggaaggca	15	3	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:24617902G>A	uc001wmn.1	+	4	796	c.547G>A	c.(547-549)GAA>AAA	p.E183K	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.E32K|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_5'UTR|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	183	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		AGACAAGGTTGAAGATGATGT	0.453													0	0	0	0.001984	0	6	71										A	24617902	G	A	24617902	3	1	63	1	0	0	0	0	1	0	0	0	13487	1291	45	1	561	1	RNF31	14	24617902	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1311801	24617902	82731638	371	18766										
HECTD1	25831	broad.mit.edu	37	chr14	31575931	31575931	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgtaattttgtgttcttctCatcttcagaaagacctttgt	6	8	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:31575931C>T	uc001wrc.1	-	38	7636	c.7147G>A	c.(7147-7149)GAG>AAG	p.E2383K	HECTD1_uc001wra.1_Missense_Mutation_p.E509K|HECTD1_uc001wrb.1_Missense_Mutation_p.E509K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2383	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGTTCTTCTCATCTTCAGAA	0.378													0	0	0	0.00308	0	8	50										T	31575931	C	T	31575931	3	4	63	1	0	0	0	0	1	0	0	0	7039	835	29	1	709	1	HECTD1	14	31575931	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	6958029	31575931	75773609	372	18767										
HECTD1	25831	broad.mit.edu	37	chr14	31598386	31598386	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gttttggtcgaacccaagctGatgtcgctgctactggccac	11	12	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:31598386G>A	uc001wrc.1	-	25	4680	c.4191C>T	c.(4189-4191)ATC>ATT	p.I1397I	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Silent_p.I865I	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1397	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AACCCAAGCTGATGTCGCTGC	0.458													0	0	0	0.003163	0	12	183										A	31598386	G	A	31598386	2	1	63	1	0	0	0	0	0	0	0	1	7039	1280	45	1		1	HECTD1	14	31598386	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	22455	31598386	75751154	373	18768										
SOS2	6655	broad.mit.edu	37	chr14	50671004	50671004	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgacaaaataatttttacctCtacatcttgaacagtccttg	4	9	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:50671004C>G	uc001wxs.3	-	2	309	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	SOS2_uc010tql.1_Missense_Mutation_p.E71Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	71					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					ATTTTTACCTCTACATCTTGA	0.313													0	0	0	0.012319	0	16	158										G	50671004	C	G	50671004	3	3	63	1	0	0	0	0	1	0	0	0	14937	922	32	1	3875	1	SOS2	14	50671004	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	19072618	50671004	56678536	374	18769										
PPP2R5E	5529	broad.mit.edu	37	chr14	63888788	63888788	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	attgctgtcactaggagggaGagttctgaatatattgcaag	12	5	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:63888788G>A	uc001xgd.1	-	4	969	c.379C>T	c.(379-381)CTC>TTC	p.L127F	PPP2R5E_uc010tsf.1_Missense_Mutation_p.L51F|PPP2R5E_uc010tsg.1_Missense_Mutation_p.L51F|PPP2R5E_uc001xge.2_Missense_Mutation_p.L127F|PPP2R5E_uc010tsh.1_Missense_Mutation_p.L127F|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	127					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		CTAGGAGGGAGAGTTCTGAAT	0.423													0	0	0	0.010729	0	8	72										A	63888788	G	A	63888788	3	1	63	1	0	0	0	0	1	0	0	0	12396	942	33	1	1068	1	PPP2R5E	14	63888788	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	13217784	63888788	43460752	375	18770										
SYNE2	23224	broad.mit.edu	37	chr14	64457211	64457211	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aatggatatacaaaatatttCaagccaggagtcctttcaac	6	8	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:64457211C>G	uc001xgm.2	+	20	2626	c.2396C>G	c.(2395-2397)TCA>TGA	p.S799*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.S799*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	799	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAAAATATTTCAAGCCAGGAG	0.353													0	0	0	0.004482	0	8	94										G	64457211	C	G	64457211	4	3	63	1	0	0	0	0	0	1	0	0	15443	838	29	1	2470	1	SYNE2	14	64457211	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	568423	64457211	42892329	376	18771										
SPTB	6710	broad.mit.edu	37	chr14	65220341	65220341	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acactctgcccatggtcccgCggggccggcagcgttgcggg	16	15	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:65220341C>T	uc001xhr.2	-	32	6570	c.6516G>A	c.(6514-6516)CCG>CCA	p.P2172P	SPTB_uc001xhs.2_Silent_p.P2172P|SPTB_uc010aqi.2_Silent_p.P833P	NM_001024858	NP_001020029	P11277	SPTB1_HUMAN	spectrin beta isoform a	Error:Variant_position_missing_in_P11277_after_alignment					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CATGGTCCCGCGGGGCCGGCA	0.627													0	0	0	0.004007	0	12	140										T	65220341	C	T	65220341	2	4	63	1	0	0	0	0	0	0	0	1	15117	755	27	2		2	SPTB	14	65220341	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	763130	65220341	42129199	377	18772										
FUT8	2530	broad.mit.edu	37	chr14	66208977	66208977	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgaaattcccatggaacctgGagatatcattggtgtggctg	12	7	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:66208977G>C	uc001xin.2	+	11	2774	c.1577G>C	c.(1576-1578)GGA>GCA	p.G526A	FUT8_uc001xio.2_Missense_Mutation_p.G526A|FUT8_uc010tsp.1_Missense_Mutation_p.G363A|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.G526A|FUT8_uc001xiq.2_Missense_Mutation_p.G397A|FUT8_uc001xis.2_Missense_Mutation_p.G120A	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	526	SH3.|Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		ATGGAACCTGGAGATATCATT	0.453													0	0	0	0.006122	0	13	128										C	66208977	G	C	66208977	3	2	63	1	0	0	0	0	1	0	0	0	6110	1174	41	1	1710	1	FUT8	14	66208977	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	988636	66208977	41140563	378	18773										
TTC9	23508	broad.mit.edu	37	chr14	71137851	71137851	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaactcagccgatgctcccaGagagaaaaagaagccatgta	9	10	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:71137851G>A	uc001xmi.2	+	3	991	c.648G>A	c.(646-648)CAG>CAA	p.Q216Q		NM_015351	NP_056166	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	216							binding				0				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		GATGCTCCCAGAGAGAAAAAG	0.567													0	0	0	0.00308	0	6	37										A	71137851	G	A	71137851	2	1	63	1	0	0	0	0	0	0	0	1	16712	933	33	1		1	TTC9	14	71137851	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4928874	71137851	36211689	379	18774										
NRXN3	9369	broad.mit.edu	37	chr14	79270147	79270147	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagctggatggggggcgtgtCaagctcatggttaacttagg	17	6	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:79270147C>G	uc001xun.2	+	6	1601	c.1110C>G	c.(1108-1110)GTC>GTG	p.V370V	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.V504V	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	743	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGGGGCGTGTCAAGCTCATGG	0.522													0	0	0	0.000602	0	5	42										G	79270147	C	G	79270147	2	3	63	1	0	0	0	0	0	0	0	1	10667	813	29	1		1	NRXN3	14	79270147	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	8132296	79270147	28079393	380	18775										
TSHR	7253	broad.mit.edu	37	chr14	81609311	81609311	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagtccttgatgtgtaatgaGagcagtatgcagagcttgcg	14	6	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:81609311G>C	uc001xvd.1	+	10	1065	c.909G>C	c.(907-909)GAG>GAC	p.E303D		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	303	Extracellular (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TGTGTAATGAGAGCAGTATGC	0.343			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						0	0	0	0.004482	0	6	92										C	81609311	G	C	81609311	3	2	63	1	0	0	0	0	1	0	0	0	16619	933	33	1	1084	1	TSHR	14	81609311	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2339164	81609311	25740229	381	18776										
STON2	85439	broad.mit.edu	37	chr14	81744768	81744768	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagaaggcgtgcggtttaaaGaggaaatatccagcttctga	12	7	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:81744768G>A	uc010tvu.1	-	4	1088	c.887C>T	c.(886-888)TCT>TTT	p.S296F	STON2_uc001xvk.1_Missense_Mutation_p.S296F|STON2_uc010tvt.1_Missense_Mutation_p.S93F	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	296					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GCGGTTTAAAGAGGAAATATC	0.468													0	0	0	0.00308	0	7	97										A	81744768	G	A	81744768	3	1	63	1	0	0	0	0	1	0	0	0	15317	942	33	1	1836	1	STON2	14	81744768	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	135457	81744768	25604772	382	18777										
SERPINA6	866	broad.mit.edu	37	chr14	94780794	94780794	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagatgctcacaggggagatGaaaatgttctttttgggact	13	5	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:94780794G>A	uc001ycv.2	-	2	296	c.192C>T	c.(190-192)TTC>TTT	p.F64F	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	64					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CAGGGGAGATGAAAATGTTCT	0.552													0	0	0	0.004482	0	7	44										A	94780794	G	A	94780794	2	1	63	1	0	0	0	0	0	0	0	1	14093	1281	45	1		1	SERPINA6	14	94780794	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	13036026	94780794	12568746	383	18778										
SERPINA3	12	broad.mit.edu	37	chr14	95080900	95080900	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gacccaggagaaccaagaccGagggacacacgtggacctcg	13	13	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:95080900G>A	uc001ydp.2	+	2	201	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	SERPINA3_uc001ydo.3_Missense_Mutation_p.R66Q|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.R41Q|SERPINA3_uc001yds.2_Missense_Mutation_p.R41Q|SERPINA3_uc010avg.2_Missense_Mutation_p.R41Q	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	41					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AACCAAGACCGAGGGACACAC	0.582													0	0	0	0.004007	0	13	123										A	95080900	G	A	95080900	3	1	63	1	0	0	0	0	1	0	0	0	14090	1058	37	1	124	1	SERPINA3	14	95080900	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	300106	95080900	12268640	384	18779										
AK7	122481	broad.mit.edu	37	chr14	96912869	96912869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcagagtgatacaaaacgtCatagatcacgtgccaaagcc	9	10	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:96912869C>T	uc001yfn.2	+	8	839	c.795C>T	c.(793-795)GTC>GTT	p.V265V		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	265	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TACAAAACGTCATAGATCACG	0.443													0	0	0	0.00308	0	5	70										T	96912869	C	T	96912869	2	4	63	1	0	0	0	0	0	0	0	1	444	813	29	1		1	AK7	14	96912869	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1831969	96912869	10436671	385	18780										
C14orf68	283600	broad.mit.edu	37	chr14	100795964	100795964	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaggcagtgctgaggctcgcCcggggtctgctcacatagcc	15	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:100795964C>T	uc001yhc.2	+	6	982	c.909C>T	c.(907-909)GCC>GCT	p.A303A	C14orf68_uc001yhd.2_Silent_p.A157A	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	303					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				TGAGGCTCGCCCGGGGTCTGC	0.652													0	0	0	0.007291	0	24	110										T	100795964	C	T	100795964	2	4	63	1	0	0	0	0	0	0	0	1	1778	610	22	2		2	C14orf68	14	100795964	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3883095	100795964	6553576	386	18781										
DYNC1H1	1778	broad.mit.edu	37	chr14	102516520	102516520	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtcaagcagacaaacaccgaGaagaaggccagtgtggtaag	13	8	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:102516520G>C	uc001yks.2	+	77	13961	c.13797G>C	c.(13795-13797)GAG>GAC	p.E4599D		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4599					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CAAACACCGAGAAGAAGGCCA	0.592													0	0	0	0.001168	0	5	62										C	102516520	G	C	102516520	3	2	63	1	0	0	0	0	1	0	0	0	4841	933	33	1	14103	1	DYNC1H1	14	102516520	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1720556	102516520	4833020	387	18782										
CYFIP1	23191	broad.mit.edu	37	chr15	22929848	22929848	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttcgctgtgctggacgagctGaagaacatgaagtgcagtgt	14	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:22929848G>A	uc001yus.2	+	6	626	c.522G>A	c.(520-522)CTG>CTA	p.L174L	CYFIP1_uc001yut.2_Silent_p.L174L|CYFIP1_uc010aya.1_Silent_p.L202L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	174					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TGGACGAGCTGAAGAACATGA	0.582													0	0	0	0.006214	0	7	54										A	22929848	G	A	22929848	2	1	63	1	0	0	0	0	0	0	0	1	4137	1277	45	1		1	CYFIP1	15	22929848	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		22929848	79601544	388	18783										
UBE3A	7337	broad.mit.edu	37	chr15	25601128	25601128	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaaaagatctgtctgtgataTctggaaagtgatcatcatgt	9	5	5	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:25601128T>C	uc001zaq.2	-	7	2044	c.2044A>G	c.(2044-2046)ATA>GTA	p.I682V	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.I659V|UBE3A_uc001zas.2_Missense_Mutation_p.I679V|UBE3A_uc001zat.2_Missense_Mutation_p.I659V	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	682					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GTCTGTGATATCTGGAAAGTG	0.323													0	0	0	0.00308	0	7	137										C	25601128	T	C	25601128	3	2	63	1	0	0	0	0	1	0	0	0	16876	1435	50	5	603	5	UBE3A	15	25601128	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	2671280	25601128	76930264	389	18784										
RYR3	6263	broad.mit.edu	37	chr15	34015011	34015011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcggggtgaggggggaaacGggctcttggcagccatgcag	20	8	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:34015011G>A	uc001zhi.2	+	44	6785	c.6715G>A	c.(6715-6717)GGG>AGG	p.G2239R	RYR3_uc010bar.2_Missense_Mutation_p.G2239R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2239	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGGGGAAACGGGCTCTTGGC	0.572													0	0	0	0.00333	0	23	117										A	34015011	G	A	34015011	3	1	63	1	0	0	0	0	1	0	0	0	13770	1116	39	2	6889	2	RYR3	15	34015011	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8413883	34015011	68516381	390	18785										
PLCB2	5330	broad.mit.edu	37	chr15	40586548	40586548	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcttgtccggccggcgcatGaactcatgcttgaggaggta	14	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:40586548G>A	uc001zld.2	-	19	2281	c.1980C>T	c.(1978-1980)TTC>TTT	p.F660F	PLCB2_uc010bbo.2_Silent_p.F656F|PLCB2_uc010ucm.1_Silent_p.F660F	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	660	PI-PLC Y-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GCCGGCGCATGAACTCATGCT	0.592													0	0	0	0.008871	0	18	50										A	40586548	G	A	40586548	2	1	63	1	0	0	0	0	0	0	0	1	12028	1281	45	1		1	PLCB2	15	40586548	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	6571537	40586548	61944844	391	18786										
INO80	54617	broad.mit.edu	37	chr15	41313219	41313219	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccagttcaggggccccattCaacaaacactgcttggctgc	10	14	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:41313219C>T	uc001zni.2	-	26	3366	c.3153G>A	c.(3151-3153)TTG>TTA	p.L1051L	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1051	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						GGGCCCCATTCAACAAACACT	0.527													0	0	0	0.001855	0	10	57										T	41313219	C	T	41313219	2	4	63	1	0	0	0	0	0	0	0	1	7746	825	29	1		1	INO80	15	41313219	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	726671	41313219	61218173	392	18787										
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42134022	42134022	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggttcctgtttccagcctcaGagcacagagttcagcttgtg	11	11	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:42134022G>A	uc010bco.2	+	8	597	c.496G>A	c.(496-498)GAG>AAG	p.E166K	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.E397K|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.E397K|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	166					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						TCCAGCCTCAGAGCACAGAGT	0.637													0	0	0	0.001168	0	5	19										A	42134022	G	A	42134022	3	1	63	1	0	0	0	0	1	0	0	0	7955	943	33	1	1239	1	JMJD7-PLA2G4B	15	42134022	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	820803	42134022	60397370	393	18788										
SLTM	79811	broad.mit.edu	37	chr15	59179635	59179635	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtggtggaggctcatttcttCtggagtcactgaaatttttg	12	6	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:59179635C>T	uc002afp.2	-	18	2568	c.2480G>A	c.(2479-2481)AGA>AAA	p.R827K	SLTM_uc002afn.2_Missense_Mutation_p.R369K|SLTM_uc002afo.2_Missense_Mutation_p.R809K|SLTM_uc002afq.2_Missense_Mutation_p.R396K|SLTM_uc010bgd.2_Missense_Mutation_p.R396K	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	827	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						CTCATTTCTTCTGGAGTCACT	0.463													0	0	0	0.007413	0	17	71										T	59179635	C	T	59179635	3	4	63	1	0	0	0	0	1	0	0	0	14754	913	32	1	640	1	SLTM	15	59179635	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	17045613	59179635	43351757	394	18789										
CORO2B	10391	broad.mit.edu	37	chr15	69003924	69003924	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggtgagccggtgaagatgaTtgactgccacacggatgtga	16	7	0	6			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:69003924T>C	uc002arj.3	+	5	556	c.527T>C	c.(526-528)ATT>ACT	p.I176T	CORO2B_uc010bic.2_Missense_Mutation_p.I171T|CORO2B_uc002ark.2_5'Flank	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	176	WD 2.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						GTGAAGATGATTGACTGCCAC	0.592													0	0	0	0.00308	0	6	46										C	69003924	T	C	69003924	3	2	63	1	0	0	0	0	1	0	0	0	3757	1493	52	5	545	5	CORO2B	15	69003924	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	9824289	69003924	33527468	395	18790										
GRAMD2	196996	broad.mit.edu	37	chr15	72455648	72455648	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agccggtaatcccagagcctCagctccccagtgctcctggg	11	16	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:72455648C>T	uc002atq.2	-	10	939	c.915G>A	c.(913-915)CTG>CTA	p.L305L	GRAMD2_uc010bis.2_Silent_p.L305L|GRAMD2_uc010ukh.1_Silent_p.L99L	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	305						integral to membrane					0						CCCAGAGCCTCAGCTCCCCAG	0.562													0	0	0	0.00308	0	6	53										T	72455648	C	T	72455648	2	4	63	1	0	0	0	0	0	0	0	1	6750	813	29	1		1	GRAMD2	15	72455648	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3451724	72455648	30075744	396	18791										
CSPG4	1464	broad.mit.edu	37	chr15	75968309	75968309	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctctggcttccctgcttccGtccgggcggcctcggggaca	13	16	1	0	rs139798032	byFrequency	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:75968309G>A	uc002baw.2	-	10	6644	c.6551C>T	c.(6550-6552)ACG>ATG	p.T2184M		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	2184	Extracellular (Potential).|Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCCTGCTTCCGTCCGGGCGGC	0.687													0	0	0	0.004672	0	3	13										A	75968309	G	A	75968309	3	1	63	1	0	0	0	0	1	0	0	0	3960	1145	40	2	421	2	CSPG4	15	75968309	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3512661	75968309	26563083	397	18792										
IL16	3603	broad.mit.edu	37	chr15	81552159	81552159	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaagcctggaaaactagaagCacaaagtagtaacttcctgt	8	8	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:81552159C>A	uc002bgh.3	+	3	735	c.359C>A	c.(358-360)GCA>GAA	p.A120E	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.A120E|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.A162E|IL16_uc002bgg.2_Missense_Mutation_p.A120E	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	120					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity	p.A120E(1)		ovary(2)|lung(1)|skin(1)	4						AAACTAGAAGCACAAAGTAGT	0.443													1	0	9.31168e-06	0.001855	9.87104e-06	11	53										A	81552159	C	A	81552159	3	1	63	1	0	0	0	0	1	0	0	0	7633	710	25	4	365	4	IL16	15	81552159	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5583850	81552159	20979233	398	18793										
SOX8	30812	broad.mit.edu	37	chr16	1035195	1035195	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccggctcacagggcgactatGgcgacctgcaggcctccagc	13	16	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:1035195G>A	uc002ckn.2	+	3	1265	c.1150G>A	c.(1150-1152)GGC>AGC	p.G384S		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	384					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				GGGCGACTATGGCGACCTGCA	0.617													0	0	0	0.000602	0	5	15										A	1035195	G	A	1035195	3	1	63	1	0	0	0	0	1	0	0	0	14957	1348	47	2	1160	2	SOX8	16	1035195	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		1035195	89319558	399	18794										
UBE2I	7329	broad.mit.edu	37	chr16	1374763	1374763	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggagtacgagaaaagggtccGagcacaagccaagaagtttg	14	7	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:1374763G>A	uc002clc.1	+	7	550	c.446G>A	c.(445-447)CGA>CAA	p.R149Q	UBE2I_uc002cld.1_Missense_Mutation_p.R149Q|UBE2I_uc002clf.1_Missense_Mutation_p.R149Q|UBE2I_uc002clg.1_Missense_Mutation_p.R149Q	NM_194261	NP_919237	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	149					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|skin(1)	2		Hepatocellular(780;0.00369)				AAAAGGGTCCGAGCACAAGCC	0.522													0	0	0	0.006214	0	9	59										A	1374763	G	A	1374763	3	1	63	1	0	0	0	0	1	0	0	0	16856	1058	37	1	468	1	UBE2I	16	1374763	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	339568	1374763	88979990	400	18795										
PKD1	5310	broad.mit.edu	37	chr16	2155953	2155953	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agccctgggagcacactagcGgtgagcccgtgcagccagac	14	14	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:2155953G>A	uc002cos.1	-	20	7985	c.7776C>T	c.(7774-7776)ACC>ACT	p.T2592T	PKD1_uc002cot.1_Silent_p.T2592T|PKD1_uc010bse.1_5'Flank	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2592	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GCACACTAGCGGTGAGCCCGT	0.662													0	0	0	0.001168	0	4	44										A	2155953	G	A	2155953	2	1	63	1	0	0	0	0	0	0	0	1	11963	1103	39	2		2	PKD1	16	2155953	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	781190	2155953	88198800	401	18796										
CLEC16A	23274	broad.mit.edu	37	chr16	11145497	11145497	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgatgtggagaagacccggcGggtgagtgagcacaggacct	17	9	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:11145497G>T	uc002dao.2	+	18	2224	c.1994G>T	c.(1993-1995)CGG>CTG	p.R665L	CLEC16A_uc002dan.3_Missense_Mutation_p.R647L	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	665										ovary(1)|central_nervous_system(1)	2						AAGACCCGGCGGGTGAGTGAG	0.602													1	0	2.23348e-06	0.004007	2.3845e-06	13	54										T	11145497	G	T	11145497	3	4	63	1	0	0	0	0	1	0	0	0	3500	1130	39	4	2060	4	CLEC16A	16	11145497	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8989544	11145497	79209256	402	18797										
TXNDC11	51061	broad.mit.edu	37	chr16	11792094	11792094	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	actcttgcctccgtgtggccGcagccaccgaaagagcgtct	11	15	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:11792094G>A	uc010buu.1	-	8	1137	c.1075C>T	c.(1075-1077)CGG>TGG	p.R359W	TXNDC11_uc002dbg.1_Missense_Mutation_p.R332W	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	359					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						CCGTGTGGCCGCAGCCACCGA	0.527													0	0	0	0.009096	0	3	75										A	11792094	G	A	11792094	3	1	63	1	0	0	0	0	1	0	0	0	16789	1086	38	2	1906	2	TXNDC11	16	11792094	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	646597	11792094	78562659	403	18798										
KIAA0430	9665	broad.mit.edu	37	chr16	15706612	15706612	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgggggttacctacaggactCttcgaacgcagaagccaagg	13	10	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:15706612C>G	uc002ddr.2	-	17	3469	c.3276G>C	c.(3274-3276)AAG>AAC	p.K1092N	KIAA0430_uc002ddq.2_Missense_Mutation_p.K926N|KIAA0430_uc010uzv.1_Missense_Mutation_p.K1088N|KIAA0430_uc010uzw.1_Missense_Mutation_p.K1091N	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1091						peroxisome	nucleotide binding|RNA binding				0						CTACAGGACTCTTCGAACGCA	0.468													0	0	0	0.006122	0	14	137										G	15706612	C	G	15706612	3	3	63	1	0	0	0	0	1	0	0	0	8177	912	32	1	1996	1	KIAA0430	16	15706612	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3914518	15706612	74648141	404	18799										
MYH11	4629	broad.mit.edu	37	chr16	15813524	15813524	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggcaaagatctcatctctgGaggcacgggcatcttccagc	11	12	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:15813524G>A	uc002ddy.2	-	35	5107	c.5000C>T	c.(4999-5001)TCC>TTC	p.S1667F	MYH11_uc002ddv.2_Missense_Mutation_p.S1674F|MYH11_uc002ddw.2_Missense_Mutation_p.S1667F|MYH11_uc002ddx.2_Missense_Mutation_p.S1674F|MYH11_uc010bvg.2_Missense_Mutation_p.S1499F|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.S373F|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1667	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CTCATCTCTGGAGGCACGGGC	0.507			T	CBFB	AML								0	0	0	0.013537	0	9	96										A	15813524	G	A	15813524	3	1	63	1	0	0	0	0	1	0	0	0	10031	1174	41	1	981	1	MYH11	16	15813524	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	106912	15813524	74541229	405	18800										
TAOK2	9344	broad.mit.edu	37	chr16	30002499	30002499	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggcttctccagcatggctctGgggggcatcccggctgaagc	15	13	2	1	rs138517482		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:30002499G>A	uc002dvc.1	+	19	3543	c.2760G>A	c.(2758-2760)CTG>CTA	p.L920L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	809	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCATGGCTCTGGGGGGCATCC	0.677													0	0	0	0.00245	0	12	102										A	30002499	G	A	30002499	2	1	63	1	0	0	0	0	0	0	0	1	15545	1335	47	2		2	TAOK2	16	30002499	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	14188975	30002499	60352254	406	18801										
HSD3B7	80270	broad.mit.edu	37	chr16	30998197	30998197	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctggtgacgtgtgcccttCgtcccacgggcatctacggt	12	15	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:30998197C>T	uc002eaf.2	+	6	674	c.568C>T	c.(568-570)CGT>TGT	p.R190C	HSD3B7_uc010cac.2_Intron|HSD3B7_uc002eag.2_Intron|HSD3B7_uc002eah.2_Missense_Mutation_p.R190C	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	190					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						GTGTGCCCTTCGTCCCACGGG	0.682													0	0	0	0.009096	0	4	49										T	30998197	C	T	30998197	3	4	63	1	0	0	0	0	1	0	0	0	7392	884	31	1	586	1	HSD3B7	16	30998197	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	995698	30998197	59356556	407	18802										
FUS	2521	broad.mit.edu	37	chr16	31201394	31201394	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cggaaatcctatcaaggtctCatttgctactcgccgggcag	10	12	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:31201394C>A	uc002ebf.2	+	11	1183	c.1100C>A	c.(1099-1101)TCA>TAA	p.S367*	FUS_uc002ebh.2_Nonsense_Mutation_p.S366*|FUS_uc002ebg.2_Nonsense_Mutation_p.S162*|FUS_uc002ebi.2_Nonsense_Mutation_p.S368*|FUS_uc002ebj.2_Nonsense_Mutation_p.S163*|FUS_uc010caj.1_Nonsense_Mutation_p.S58*	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	367	RRM.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		ATCAAGGTCTCATTTGCTACT	0.478			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								1	0	0.00024832	0.009096	0.000257326	4	22										A	31201394	C	A	31201394	4	1	63	1	0	0	0	0	0	1	0	0	6100	838	29	3	1142	3	FUS	16	31201394	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	203197	31201394	59153359	408	18803										
GNAO1	2775	broad.mit.edu	37	chr16	56388944	56388944	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcatcattgccaacaacctCcggggctgcggcttgtactg	10	13	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:56388944C>G	uc002eiu.3	+	8	1941	c.1044C>G	c.(1042-1044)CTC>CTG	p.L348L		NM_020988	NP_066268	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	348					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				CCAACAACCTCCGGGGCTGCG	0.483													0	0	0	0.006214	0	6	71										G	56388944	C	G	56388944	2	3	63	1	0	0	0	0	0	0	0	1	6508	842	30	1		1	GNAO1	16	56388944	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	25187550	56388944	33965809	409	18804										
CNOT1	23019	broad.mit.edu	37	chr16	58576138	58576138	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agagccccaattctcactttCagcctgatttgctctggcat	7	13	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:58576138C>T	uc002env.2	-	33	4970	c.4677G>A	c.(4675-4677)CTG>CTA	p.L1559L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L1554L|CNOT1_uc010vik.1_Silent_p.L516L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1559					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTCTCACTTTCAGCCTGATTT	0.418													0	0	0	0.001984	0	7	43										T	58576138	C	T	58576138	2	4	63	1	0	0	0	0	0	0	0	1	3617	813	29	1		1	CNOT1	16	58576138	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2187194	58576138	31778615	410	18805										
FHOD1	29109	broad.mit.edu	37	chr16	67265134	67265134	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggatttctgaatagaggtcaGaggactcaggccgggtctgg	16	7	4	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:67265134G>C	uc002esl.2	-	17	2736	c.2624C>G	c.(2623-2625)TCT>TGT	p.S875C	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Missense_Mutation_p.S682C	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	875	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ATAGAGGTCAGAGGACTCAGG	0.582													0	0	0	0.00308	0	7	46										C	67265134	G	C	67265134	3	2	63	1	0	0	0	0	1	0	0	0	5882	942	33	1	894	1	FHOD1	16	67265134	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8688996	67265134	23089619	411	18806										
FAM65A	79567	broad.mit.edu	37	chr16	67575769	67575769	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atgccctctcctctttctcaGaacatgctgcgacggcagga	9	14	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:67575769G>C	uc010vjp.1	+	13	1237	c.1141_splice	c.e13-1	p.N381_splice	FAM65A_uc010cei.1_Splice_Site_p.N203_splice|FAM65A_uc002eth.2_Splice_Site_p.N361_splice|FAM65A_uc010cej.2_Splice_Site_p.N364_splice|FAM65A_uc002eti.1_Splice_Site_p.N324_splice|FAM65A_uc010vjq.1_Splice_Site_p.N375_splice|FAM65A_uc002etj.1_Splice_Site_p.N360_splice|FAM65A_uc002etk.2_Splice_Site_p.N360_splice	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567							cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CTCTTTCTCAGAACATGCTGC	0.577													0	0	0	0.009096	0	4	57										C	67575769	G	C	67575769	5	2	63	1	0	0	0	0	0	0	1	0	5599	956	33	1	1126	1	FAM65A	16	67575769	Splice_Site	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	310635	67575769	22778984	412	18807										
NFATC3	4775	broad.mit.edu	37	chr16	68160443	68160443	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcaacctaaaactcatcatcGagcccattatgaaactgaag	6	11	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:68160443G>A	uc002evo.1	+	3	1541	c.1331G>A	c.(1330-1332)CGA>CAA	p.R444Q	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.R444Q|NFATC3_uc002evm.1_Missense_Mutation_p.R444Q|NFATC3_uc002evn.1_Missense_Mutation_p.R444Q|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	444	RHD.|				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		ACTCATCATCGAGCCCATTAT	0.443													0	0	0	0.00308	0	7	74										A	68160443	G	A	68160443	3	1	63	1	0	0	0	0	1	0	0	0	10364	1058	37	1	1341	1	NFATC3	16	68160443	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	584674	68160443	22194310	413	18808										
C16orf7	9605	broad.mit.edu	37	chr16	89775292	89775292	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgcagcgatgggcgggggcCcggcctggggtgtggcctct	20	12	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:89775292C>A	uc002fom.1	-	13	1795	c.1670G>T	c.(1669-1671)GGG>GTG	p.G557V	C16orf7_uc002fol.1_Missense_Mutation_p.G487V|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	557	VPS9.				ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGGCGGGGGCCCGGCCTGGGG	0.667													1	0	2.7689e-08	0.001984	2.9988e-08	5	19										A	89775292	C	A	89775292	3	1	63	1	0	0	0	0	1	0	0	0	1828	623	22	4	237	4	C16orf7	16	89775292	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	21614849	89775292	579461	414	18809										
ENO3	2027	broad.mit.edu	37	chr17	4859247	4859247	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	accccaccagtggtctccatCgaagacccctttgaccagga	8	16	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:4859247C>T	uc002gab.3	+	9	970	c.876C>T	c.(874-876)ATC>ATT	p.I292I	ENO3_uc002gac.3_Silent_p.I292I|ENO3_uc010vss.1_Silent_p.I249I|ENO3_uc010vst.1_Silent_p.I128I	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	292					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						TGGTCTCCATCGAAGACCCCT	0.358													0	0	0	0.003755	0	29	234										T	4859247	C	T	4859247	2	4	63	1	0	0	0	0	0	0	0	1	5123	874	31	1		1	ENO3	17	4859247	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		4859247	76335963	415	18810										
TP53	7157	broad.mit.edu	37	chr17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cttgcggagattctcttcctCtgtgcgccggtctctcccag	10	15	3	1	rs112431538		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00499	0	18	32										T	7577085	C	T	7577085	3	4	63	1	0	0	0	0	1	0	0	0	16378	922	32	1	433	1	TP53	17	7577085	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2717838	7577085	73618125	416	18811										
MYH2	4620	broad.mit.edu	37	chr17	10440759	10440759	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgggcttctggaagttggcaGacttgcccaggtgctggtca	15	9	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:10440759G>C	uc010coi.2	-	16	1816	c.1688C>G	c.(1687-1689)TCT>TGT	p.S563C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.S563C|MYH2_uc010coj.2_Missense_Mutation_p.S563C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	563	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GAAGTTGGCAGACTTGCCCAG	0.532													0	0	0	0.006214	0	9	119										C	10440759	G	C	10440759	3	2	63	1	0	0	0	0	1	0	0	0	10035	942	33	1	4237	1	MYH2	17	10440759	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2863674	10440759	70754451	417	18812										
DNAH9	1770	broad.mit.edu	37	chr17	11522879	11522879	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	taccaggcctctaattatctCagcccagaagacctgctgag	8	13	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:11522879C>G	uc002gne.2	+	6	1199	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	377	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTAATTATCTCAGCCCAGAAG	0.448													0	0	0	0.004482	0	6	93										G	11522879	C	G	11522879	2	3	63	1	0	0	0	0	0	0	0	1	4608	813	29	1		1	DNAH9	17	11522879	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1082120	11522879	69672331	418	18813										
TEKT3	64518	broad.mit.edu	37	chr17	15234758	15234758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtatgtgctgggtctccaagGaaggctcaggctatgggtca	15	8	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:15234758G>A	uc002gon.2	-	3	332	c.145C>T	c.(145-147)CCT>TCT	p.P49S		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	49					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		GGTCTCCAAGGAAGGCTCAGG	0.542													0	0	0	0.009096	0	4	30										A	15234758	G	A	15234758	3	1	63	1	0	0	0	0	1	0	0	0	15751	1174	41	1	1355	1	TEKT3	17	15234758	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3711879	15234758	65960452	419	18814										
ZNF286A	57335	broad.mit.edu	37	chr17	15604513	15604513	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccaagagaagagcacagaaGagggagaagtggctgctctg	15	7	1	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:15604513G>C	uc010cot.2	+	3	481	c.85G>C	c.(85-87)GAG>CAG	p.E29Q	ZNF286A_uc002goz.3_5'UTR|ZNF286A_uc010vwa.1_Missense_Mutation_p.E29Q|ZNF286A_uc002gpa.2_Missense_Mutation_p.E29Q	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GAGCACAGAAGAGGGAGAAGT	0.498													0	0	0	0.004672	0	3	188										C	15604513	G	C	15604513	3	2	63	1	0	0	0	0	1	0	0	0	17820	943	33	1	91	1	ZNF286A	17	15604513	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	369755	15604513	65590697	420	18815										
NCOR1	9611	broad.mit.edu	37	chr17	15967466	15967466	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctcccgttcccgttccctctCagcacttgcagcagctgcaa	7	18	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:15967466C>T	uc002gpo.2	-	35	5377	c.5137G>A	c.(5137-5139)GAG>AAG	p.E1713K	NCOR1_uc002gpn.2_Missense_Mutation_p.E1729K|NCOR1_uc002gpm.2_Missense_Mutation_p.E233K|NCOR1_uc010vwb.1_Missense_Mutation_p.E297K|NCOR1_uc010coy.2_Missense_Mutation_p.E621K|NCOR1_uc010vwc.1_Missense_Mutation_p.E523K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1713	Interaction with ETO.|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		cgttccctctcAGCACTTGCA	0.363													0	0	0	0.009096	0	3	67										T	15967466	C	T	15967466	3	4	63	1	0	0	0	0	1	0	0	0	10235	835	29	1	2233	1	NCOR1	17	15967466	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	362953	15967466	65227744	421	18816										
KIAA0100	9703	broad.mit.edu	37	chr17	26958554	26958554	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agggaggacaagctcagcagGtgggtctttgttaccaaggg	16	7	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:26958554G>A	uc002hbu.2	-	23	4341	c.4242C>T	c.(4240-4242)CAC>CAT	p.H1414H		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1414						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGCTCAGCAGGTGGGTCTTTG	0.483													0	0	0	0.004482	0	6	77										A	26958554	G	A	26958554	2	1	63	1	0	0	0	0	0	0	0	1	8154	1252	44	2		2	KIAA0100	17	26958554	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	10991088	26958554	54236656	422	18817										
DHRS13	147015	broad.mit.edu	37	chr17	27228598	27228598	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgaggccagactggccaagtCcaaggccatgaagatgacct	12	12	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:27228598C>T	uc002hde.3	-	3	410	c.283G>A	c.(283-285)GAC>AAC	p.D95N	DHRS13_uc002hdd.3_Missense_Mutation_p.D45N|DHRS13_uc010wba.1_Intron	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	95						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			CTGGCCAAGTCCAAGGCCATG	0.602													0	0	0	0.000602	0	3	81										T	27228598	C	T	27228598	3	4	63	1	0	0	0	0	1	0	0	0	4489	855	30	1	862	1	DHRS13	17	27228598	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	270044	27228598	53966612	423	18818										
EFCAB5	374786	broad.mit.edu	37	chr17	28296147	28296147	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atactgcatatttgcttgacAaacttctacccaccttagtt	4	11	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:28296147A>T	uc002het.2	+	4	721	c.529A>T	c.(529-531)AAA>TAA	p.K177*	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Nonsense_Mutation_p.K121*|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Nonsense_Mutation_p.K56*|EFCAB5_uc010csf.2_Nonsense_Mutation_p.K56*	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	177							calcium ion binding			ovary(1)|skin(1)	2						TTTGCTTGACAAACTTCTACC	0.378													0	0	0	0.004672	0	3	33										T	28296147	A	T	28296147	4	4	63	1	0	0	0	0	0	1	0	0	4938	131	5	5	543	5	EFCAB5	17	28296147	Nonsense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	1067549	28296147	52899063	424	18819										
LRRC37B	114659	broad.mit.edu	37	chr17	30348952	30348952	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gactttctcaattccatctaGagcccaaaagtcaaaatcca	4	12	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:30348952G>C	uc002hgu.2	+	1	798	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	LRRC37B_uc010wbx.1_Missense_Mutation_p.E181Q|LRRC37B_uc010csu.2_Missense_Mutation_p.E263Q	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	263	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ATTCCATCTAGAGCCCAAAAG	0.547													0	0	0	0.003163	0	13	146										C	30348952	G	C	30348952	3	2	63	1	0	0	0	0	1	0	0	0	8994	943	33	1	789	1	LRRC37B	17	30348952	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2052805	30348952	50846258	425	18820										
TMEM132E	124842	broad.mit.edu	37	chr17	32964905	32964905	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agcaggcaacccgctggaaaCcgtgcccgccttctgccacg	11	17	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:32964905C>T	uc002hif.2	+	10	2937	c.2609C>T	c.(2608-2610)ACC>ATC	p.T870I		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	870	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCGCTGGAAACCGTGCCCGCC	0.706													0	0	0	0.001984	0	6	22										T	32964905	C	T	32964905	3	4	63	1	0	0	0	0	1	0	0	0	16045	507	18	2	2647	2	TMEM132E	17	32964905	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2615953	32964905	48230305	426	18821										
SLFN5	162394	broad.mit.edu	37	chr17	33591520	33591520	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaacaaaggcggctacactgGgaggttatgcatcaccccct	11	12	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:33591520G>C	uc002hjf.3	+	4	1574	c.1457G>C	c.(1456-1458)GGG>GCG	p.G486A	SLFN5_uc010wcg.1_Intron	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	486					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GGCTACACTGGGAGGTTATGC	0.453													0	0	0	0.00308	0	8	61										C	33591520	G	C	33591520	3	2	63	1	0	0	0	0	1	0	0	0	14737	1232	43	4	1467	4	SLFN5	17	33591520	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	626615	33591520	47603690	427	18822										
DHRS11	79154	broad.mit.edu	37	chr17	34956406	34956406	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctggtgctctcagtgtctCaaacccgaggatgtggccga	12	13	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:34956406C>T	uc002hnd.2	+	6	895	c.681C>T	c.(679-681)CTC>CTT	p.L227L	MRM1_uc002hne.2_5'Flank|MRM1_uc002hnf.2_5'Flank	NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	227						extracellular region	binding|oxidoreductase activity				0						CTCAGTGTCTCAAACCCGAGG	0.567													0	0	0	0.001984	0	5	31										T	34956406	C	T	34956406	2	4	63	1	0	0	0	0	0	0	0	1	4487	813	29	1		1	DHRS11	17	34956406	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1364886	34956406	46238804	428	18823										
MLLT6	4302	broad.mit.edu	37	chr17	36877001	36877001	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgctgtccacttcttctgagGtgggcgctacgaggagtggg	16	10	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:36877001G>A	uc002hqi.3	+	16	2455	c.2442_splice	c.e16+1	p.E814_splice	MLLT6_uc002hqj.2_Missense_Mutation_p.V250M|MLLT6_uc002hqk.3_Splice_Site_p.E145_splice	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					TTCTTCTGAGGTGGGCGCTAC	0.632			T	MLL	AL								0	0	0	0.001168	0	5	38										A	36877001	G	A	36877001	5	1	63	1	0	0	0	0	0	0	1	0	9630	1275	44	2	2505	2	MLLT6	17	36877001	Splice_Site	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1920595	36877001	44318209	429	18824										
NR1D1	9572	broad.mit.edu	37	chr17	38250311	38250311	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cctgcaggctgtaggtggtgCggcttaggaacatcactgtc	14	10	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:38250311C>T	uc002htz.1	-	7	2125	c.1499G>A	c.(1498-1500)CGC>CAC	p.R500H	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_Missense_Mutation_p.R114H	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	500					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					GTAGGTGGTGCGGCTTAGGAA	0.572													0	0	0	0.014323	0	17	170										T	38250311	C	T	38250311	3	4	63	1	0	0	0	0	1	0	0	0	10615	768	27	2	353	2	NR1D1	17	38250311	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1373310	38250311	42944899	430	18825										
ACBD4	79777	broad.mit.edu	37	chr17	43214493	43214493	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggcccccagagaccttcctGagaagggtcacaggtcagac	12	13	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:43214493G>A	uc002iid.2	+	5	746	c.402G>A	c.(400-402)CTG>CTA	p.L134L	ACBD4_uc010wjj.1_Silent_p.L134L|ACBD4_uc002iie.2_Silent_p.L134L|ACBD4_uc002iif.2_Silent_p.L134L|ACBD4_uc002iic.2_Silent_p.L134L|ACBD4_uc010dae.2_Silent_p.L56L	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	134							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						AGACCTTCCTGAGAAGGGTCA	0.607													0	0	0	0.000602	0	3	52										A	43214493	G	A	43214493	2	1	63	1	0	0	0	0	0	0	0	1	124	1277	45	1		1	ACBD4	17	43214493	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	4964182	43214493	37980717	431	18826										
HOXB1	3211	broad.mit.edu	37	chr17	46606964	46606964	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggtgcatgtcgactggtctGaggcatctccagctgcctcc	12	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:46606964G>A	uc002ink.1	-	2	857	c.851C>T	c.(850-852)TCA>TTA	p.S284L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	284						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGACTGGTCTGAGGCATCTCC	0.637													0	0	0	0.001984	0	6	48										A	46606964	G	A	46606964	3	1	63	1	0	0	0	0	1	0	0	0	7299	1294	45	1	58	1	HOXB1	17	46606964	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3392471	46606964	34588246	432	18827										
HOXB1	3211	broad.mit.edu	37	chr17	46607120	46607120	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggcggcaatctccaccctcCgggcccggctcaggtacttg	12	16	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:46607120C>T	uc002ink.1	-	2	701	c.695G>A	c.(694-696)CGG>CAG	p.R232Q		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	232	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCCACCCTCCGGGCCCGGCT	0.572													0	0	0	0.003163	0	14	172										T	46607120	C	T	46607120	3	4	63	1	0	0	0	0	1	0	0	0	7299	652	23	2	214	2	HOXB1	17	46607120	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	156	46607120	34588090	433	18828										
CACNA1G	8913	broad.mit.edu	37	chr17	48701395	48701395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgggagcactgccgaggggcCcctgggacacaggggctggg	20	11	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:48701395C>T	uc002irk.1	+	36	6560	c.6188C>T	c.(6187-6189)CCC>CTC	p.P2063L	CACNA1G_uc002irj.1_Missense_Mutation_p.P1936L|CACNA1G_uc002irl.1_Missense_Mutation_p.P1947L|CACNA1G_uc002irm.1_Missense_Mutation_p.P1984L|CACNA1G_uc002irn.1_Missense_Mutation_p.P1929L|CACNA1G_uc002iro.1_Missense_Mutation_p.P1936L|CACNA1G_uc002irp.1_Missense_Mutation_p.P2018L|CACNA1G_uc002irq.1_Missense_Mutation_p.P2040L|CACNA1G_uc002irr.1_Missense_Mutation_p.P1970L|CACNA1G_uc002irs.1_Missense_Mutation_p.P2007L|CACNA1G_uc002irt.1_Missense_Mutation_p.P1952L|CACNA1G_uc002irv.1_Missense_Mutation_p.P1959L|CACNA1G_uc002irw.1_Missense_Mutation_p.P1992L|CACNA1G_uc002iru.1_Missense_Mutation_p.P2029L|CACNA1G_uc002irx.1_Missense_Mutation_p.P1883L|CACNA1G_uc002iry.1_Missense_Mutation_p.P1872L|CACNA1G_uc002irz.1_Missense_Mutation_p.P1876L|CACNA1G_uc002isa.1_Missense_Mutation_p.P1849L|CACNA1G_uc002isb.1_Missense_Mutation_p.P1890L|CACNA1G_uc002isc.1_Missense_Mutation_p.P1965L|CACNA1G_uc002isd.1_Missense_Mutation_p.P1858L|CACNA1G_uc002ise.1_Missense_Mutation_p.P1886L|CACNA1G_uc002isf.1_Missense_Mutation_p.P1913L|CACNA1G_uc002isg.1_Missense_Mutation_p.P1831L|CACNA1G_uc002ish.1_Missense_Mutation_p.P1838L|CACNA1G_uc002isi.1_Missense_Mutation_p.P1826L	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2063	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCCGAGGGGCCCCTGGGACAC	0.612													0	0	0	0.001855	0	10	55										T	48701395	C	T	48701395	3	4	63	1	0	0	0	0	1	0	0	0	2544	623	22	2	6597	2	CACNA1G	17	48701395	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2094275	48701395	32493815	434	18829										
C17orf71	55181	broad.mit.edu	37	chr17	57289713	57289713	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	attttccaggagaaaaaccaGaggctgatagaaatccgcct	9	9	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:57289713G>C	uc002ixi.2	+	2	1813	c.1771G>C	c.(1771-1773)GAG>CAG	p.E591Q		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	591					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					AGAAAAACCAGAGGCTGATAG	0.408													0	0	0	0.00308	0	6	135										C	57289713	G	C	57289713	3	2	63	1	0	0	0	0	1	0	0	0	1878	943	33	1	1777	1	C17orf71	17	57289713	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8588318	57289713	23905497	435	18830										
USP32	84669	broad.mit.edu	37	chr17	58313541	58313541	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgttgccaccactgcatggaGatgataaaccagttgtgtcc	10	10	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:58313541G>A	uc002iyo.1	-	12	1483	c.1197C>T	c.(1195-1197)ATC>ATT	p.I399I	USP32_uc002iyn.1_Silent_p.I69I	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	399	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACTGCATGGAGATGATAAACC	0.393													0	0	0	0.010729	0	8	172										A	58313541	G	A	58313541	2	1	63	1	0	0	0	0	0	0	0	1	17060	932	33	1		1	USP32	17	58313541	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1023828	58313541	22881669	436	18831										
USP32	84669	broad.mit.edu	37	chr17	58422944	58422944	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtcctcttgaaagcatccttCagtcgttttagctctacatc	6	12	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:58422944C>T	uc002iyo.1	-	2	370	c.84G>A	c.(82-84)CTG>CTA	p.L28L	USP32_uc010wov.1_Silent_p.L28L	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	28					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AAGCATCCTTCAGTCGTTTTA	0.458													0	0	0	0.000602	0	4	79										T	58422944	C	T	58422944	2	4	63	1	0	0	0	0	0	0	0	1	17060	813	29	1		1	USP32	17	58422944	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	109403	58422944	22772266	437	18832										
ACE	1636	broad.mit.edu	37	chr17	61568636	61568636	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cctccctggggctgctgcccGtgcctcctgagttctggaac	12	16	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:61568636G>T	uc002jau.1	+	19	2828	c.2806G>T	c.(2806-2808)GTG>TTG	p.V936L	ACE_uc002jav.1_Missense_Mutation_p.V362L|ACE_uc010ddv.1_Missense_Mutation_p.V163L|ACE_uc010wpj.1_Missense_Mutation_p.V362L|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.V182L	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	936	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GCTGCTGCCCGTGCCTCCTGA	0.617													1	0	3.59834e-05	0.001168	3.77448e-05	6	44										T	61568636	G	T	61568636	3	4	63	1	0	0	0	0	1	0	0	0	136	1145	40	4	3083	4	ACE	17	61568636	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3145692	61568636	19626574	438	18833										
MAP3K3	4215	broad.mit.edu	37	chr17	61768566	61768566	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaccgcgctgagaagaccctGaccatcttcatggagtacat	10	12	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:61768566G>C	uc002jbg.2	+	13	1636	c.1317G>C	c.(1315-1317)CTG>CTC	p.L439L	MAP3K3_uc002jbe.2_Silent_p.L470L|MAP3K3_uc002jbf.2_Silent_p.L470L|MAP3K3_uc002jbh.2_Silent_p.L466L|MAP3K3_uc010wpo.1_Silent_p.L354L|MAP3K3_uc010wpp.1_Silent_p.L435L	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	439	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						AGAAGACCCTGACCATCTTCA	0.577													0	0	0	0.001168	0	5	115										C	61768566	G	C	61768566	2	2	63	1	0	0	0	0	0	0	0	1	9251	1277	45	1		1	MAP3K3	17	61768566	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	199930	61768566	19426644	439	18834										
HELZ	9931	broad.mit.edu	37	chr17	65197255	65197255	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggccttacctctgtttctGagagaagtgtttttagtctt	9	7	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:65197255G>C	uc010wqk.1	-	7	606	c.419C>G	c.(418-420)TCA>TGA	p.S140*	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Nonsense_Mutation_p.S140*|HELZ_uc010des.1_Nonsense_Mutation_p.S140*	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTCTGTTTCTGAGAGAAGTGT	0.343											OREG0024677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	78										C	65197255	G	C	65197255	4	2	63	1	0	0	0	0	0	1	0	0	7049	1294	45	1	5517	1	HELZ	17	65197255	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3428689	65197255	15997955	440	18835										
SLC39A11	201266	broad.mit.edu	37	chr17	71027826	71027826	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctcaactgctggggccagaaGagaccaataggaagctgcca	12	11	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:71027826G>A	uc002jjb.2	-	4	290	c.175C>T	c.(175-177)CTT>TTT	p.L59F	SLC39A11_uc002jja.2_Missense_Mutation_p.L59F|SLC39A11_uc002jjc.1_Missense_Mutation_p.L59F	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	59	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1						GGGGCCAGAAGAGACCAATAG	0.537													0	0	0	0.009096	0	3	32										A	71027826	G	A	71027826	3	1	63	1	0	0	0	0	1	0	0	0	14614	942	33	1	881	1	SLC39A11	17	71027826	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	5830571	71027826	10167384	441	18836										
DNAI2	64446	broad.mit.edu	37	chr17	72285872	72285872	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcgattcatacatctgggacCtgggtgagaagcagcggggt	16	8	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:72285872C>T	uc002jkf.2	+	5	706	c.607C>T	c.(607-609)CTG>TTG	p.L203L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	203	WD 1.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CATCTGGGACCTGGGTGAGAA	0.627									Kartagener_syndrome				0	0	0	0.013537	0	10	56										T	72285872	C	T	72285872	2	4	63	1	0	0	0	0	0	0	0	1	4610	680	24	2		2	DNAI2	17	72285872	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1258046	72285872	8909338	442	18837										
ARMC7	79637	broad.mit.edu	37	chr17	73124975	73124975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccgtggtgcagtgcatgcttCgcttctccctctcggccagc	11	16	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:73124975C>T	uc002jmw.1	+	3	741	c.439C>T	c.(439-441)CGC>TGC	p.R147C	ARMC7_uc010wru.1_3'UTR|ARMC7_uc010dga.1_RNA	NM_024585	NP_078861	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	147							binding			pancreas(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			GTGCATGCTTCGCTTCTCCCT	0.692													0	0	0	0.009096	0	3	30										T	73124975	C	T	73124975	3	4	63	1	0	0	0	0	1	0	0	0	956	884	31	1	449	1	ARMC7	17	73124975	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	839103	73124975	8070235	443	18838										
GALR2	8811	broad.mit.edu	37	chr17	74073116	74073117	+	Missense_Mutation	DNP	CC	CC	TT													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atgccccaccacgcgctcatCctctgcgtgtggttcggcca							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:74073116_74073117CC>TT	uc002jqm.1	+	2	849_850	c.768_769CC>TT	c.(766-771)ATCCTC>ATTTTC	p.L257F	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	257	Helical; Name=6; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						ACGCGCTCATCCTCTGCGTGTG	0.663													0	0	0	0.004672	0	4	43										TT	74073117	CC	TT	74073116	3	4	63	1	0	0	0	0	1	0	0	0	6228	845	30	1	774	1	GALR2	17	74073116	Missense_Mutation	DNP	CC	TCGA-DK-A3IU-01A-11D-A20D-08	948141	74073116	7122094	444	18839										
ZACN	353174	broad.mit.edu	37	chr17	74075572	74075572	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagaaggttcaggaaagcatCcagatcccgaacaatgggag	12	8	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:74075572C>G	uc002jqn.2	+	2	233	c.150C>G	c.(148-150)ATC>ATG	p.I50M	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_RNA	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	50	Extracellular (Potential).				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						AGGAAAGCATCCAGATCCCGA	0.547													0	0	0	0.001984	0	6	37										G	74075572	C	G	74075572	3	3	63	1	0	0	0	0	1	0	0	0	17507	845	30	1	156	1	ZACN	17	74075572	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2456	74075572	7119638	445	18840										
RHBDF2	79651	broad.mit.edu	37	chr17	74477496	74477496	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgctcgccaggggcctgggtCtctttctcgggtggcgggat	17	11	2	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:74477496C>G	uc002jrq.1	-	3	404	c.111G>C	c.(109-111)GAG>GAC	p.E37D	RHBDF2_uc002jrp.1_Missense_Mutation_p.E37D|RHBDF2_uc002jrr.1_5'UTR|RHBDF2_uc010wtf.1_Missense_Mutation_p.E37D|RHBDF2_uc002jrs.1_Missense_Mutation_p.E37D	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	37	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						GGGCCTGGGTCTCTTTCTCGG	0.637													0	0	0	0.000602	0	3	43										G	74477496	C	G	74477496	3	3	63	1	0	0	0	0	1	0	0	0	13320	912	32	1	2527	1	RHBDF2	17	74477496	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	401924	74477496	6717714	446	18841										
CBX8	57332	broad.mit.edu	37	chr17	77768460	77768460	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttctctttaaaaaagccttGgtccgtgttactttccttaa	5	9	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:77768460G>A	uc002jxd.1	-	5	1237	c.1144C>T	c.(1144-1146)CAA>TAA	p.Q382*		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	382					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AAAAAGCCTTGGTCCGTGTTA	0.498													0	0	0	0.004007	0	13	212										A	77768460	G	A	77768460	4	1	63	1	0	0	0	0	0	1	0	0	2724	1348	47	2	4	2	CBX8	17	77768460	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3290964	77768460	3426750	447	18842										
DLGAP1	9229	broad.mit.edu	37	chr18	3879141	3879141	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctggcaggagcgttcttgctGacacgactcggacttcacca	11	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:3879141G>A	uc002kmf.2	-	1	995	c.928C>T	c.(928-930)CAG>TAG	p.Q310*	DLGAP1_uc010wyz.1_Nonsense_Mutation_p.Q310*|DLGAP1_uc002kmk.2_Nonsense_Mutation_p.Q310*|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	310					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CGTTCTTGCTGACACGACTCG	0.557													0	0	0	0.013537	0	10	97										A	3879141	G	A	3879141	4	1	63	1	0	0	0	0	0	1	0	0	4559	1299	45	1	2100	1	DLGAP1	18	3879141	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08		3879141	74198107	448	18843										
CEP76	79959	broad.mit.edu	37	chr18	12673397	12673397	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgatatttacaagcaaacatGatccaaacagcacatgcaga	6	10	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:12673397G>A	uc002kri.2	-	12	2103	c.1947C>T	c.(1945-1947)ATC>ATT	p.I649I	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_Silent_p.I471I|CEP76_uc010wzz.1_Silent_p.I574I	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	649					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						AAGCAAACATGATCCAAACAG	0.378													0	0	0	0.00278	0	22	133										A	12673397	G	A	12673397	2	1	63	1	0	0	0	0	0	0	0	1	3261	1280	45	1		1	CEP76	18	12673397	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8794256	12673397	65403851	449	18844										
ANKRD30B	374860	broad.mit.edu	37	chr18	14850274	14850274	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atatattaaaagaaaaaattAgacccgaagagcaacttagg	7	5	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:14850274A>T	uc010dlo.2	+	35	3280	c.3100A>T	c.(3100-3102)AGA>TGA	p.R1034*	ANKRD30B_uc010xal.1_Nonsense_Mutation_p.R176*	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1119	Potential.									ovary(1)|skin(1)	2						AGAAAAAATTAGACCCGAAGA	0.279													0	0	0	0.001984	0	6	16										T	14850274	A	T	14850274	4	4	63	1	0	0	0	0	0	1	0	0	659	412	15	5	3238	5	ANKRD30B	18	14850274	Nonsense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	2176877	14850274	63226974	450	18845										
WDR7	23335	broad.mit.edu	37	chr18	54348569	54348569	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtgcctctgggatgtgagtGatggcagatgtattgaattt	14	4	1	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:54348569G>A	uc002lgk.1	+	4	503	c.292G>A	c.(292-294)GAT>AAT	p.D98N	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.D98N	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	98	WD 2.									ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GGATGTGAGTGATGGCAGATG	0.333													0	0	0	0.004007	0	16	146										A	54348569	G	A	54348569	3	1	63	1	0	0	0	0	1	0	0	0	17317	1290	45	1	302	1	WDR7	18	54348569	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	39498295	54348569	23728679	451	18846										
TSHZ1	10194	broad.mit.edu	37	chr18	72999153	72999153	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccactgccggcggccgtgcaGagcgtgcaggtgcagccgtc	16	15	0	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:72999153G>A	uc002lly.2	+	2	2219	c.1656G>A	c.(1654-1656)CAG>CAA	p.Q552Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	597						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CGGCCGTGCAGAGCGTGCAGG	0.682													0	0	0	0.009096	0	3	26										A	72999153	G	A	72999153	2	1	63	1	0	0	0	0	0	0	0	1	16620	933	33	1		1	TSHZ1	18	72999153	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	18650584	72999153	5078095	452	18847										
BTBD2	55643	broad.mit.edu	37	chr19	1993151	1993151	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcaccgtctccgggccaatCtgcacctcgtccgagtagag	10	15	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:1993151C>G	uc002lup.1	-	3	552	c.552G>C	c.(550-552)CAG>CAC	p.Q184H	BTBD2_uc002luo.1_5'Flank	NM_017797	NP_060267	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	184	BTB.					cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGCCAATCTGCACCTCGT	0.642													0	0	0	0.004482	0	7	44										G	1993151	C	G	1993151	3	3	63	1	0	0	0	0	1	0	0	0	1543	912	32	1	1053	1	BTBD2	19	1993151	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		1993151	57135832	453	18848										
NFIC	4782	broad.mit.edu	37	chr19	3382105	3382105	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atcctgttcaagggcatcccGctggagagcaccgacggcga	13	13	1	1	rs146650773	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:3382105G>A	uc010xhi.1	+	2	488	c.426G>A	c.(424-426)CCG>CCA	p.P142P	NFIC_uc002lxo.2_Silent_p.P133P|NFIC_uc010xhh.1_Silent_p.P133P|NFIC_uc002lxp.2_Silent_p.P142P|NFIC_uc010xhj.1_Silent_p.P142P|NFIC_uc002lxq.1_Silent_p.P94P	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	142	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		AGGGCATCCCGCTGGAGAGCA	0.672													0	0	0	0.009096	0	4	130										A	3382105	G	A	3382105	2	1	63	1	0	0	0	0	0	0	0	1	10372	1074	38	2		2	NFIC	19	3382105	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1388954	3382105	55746878	454	18849										
CHAF1A	10036	broad.mit.edu	37	chr19	4428819	4428819	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttctccttcttgaaagacctCaaaggccggcagcccctgag	9	14	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:4428819C>G	uc002mal.2	+	8	1636	c.1536C>G	c.(1534-1536)CTC>CTG	p.L512L		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	512					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAAAGACCTCAAAGGCCGGC	0.612								Chromatin_Structure					0	0	0	0.001855	0	11	60										G	4428819	C	G	4428819	2	3	63	1	0	0	0	0	0	0	0	1	3311	813	29	1		1	CHAF1A	19	4428819	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1046714	4428819	54700164	455	18850										
ZNRF4	148066	broad.mit.edu	37	chr19	5455804	5455804	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcccgcgcaggcagtggtacGggccgtgctggaagacaact	16	12	0	1	rs141487677	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:5455804G>A	uc002mca.3	+	1	379	c.302G>A	c.(301-303)CGG>CAG	p.R101Q		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	101	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCAGTGGTACGGGCCGTGCTG	0.692													0	0	0	0.005443	0	18	76										A	5455804	G	A	5455804	3	1	63	1	0	0	0	0	1	0	0	0	18211	1116	39	2	304	2	ZNRF4	19	5455804	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1026985	5455804	53673179	456	18851										
MLLT1	4298	broad.mit.edu	37	chr19	6270699	6270699	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aacaccatccagtcgtgagtGaacccctccgtggtgggctt	11	13	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:6270699G>A	uc002mek.2	-	2	248	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	28	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						AGTCGTGAGTGAACCCCTCCG	0.612			T	MLL	AL						OREG0025198	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	54										A	6270699	G	A	6270699	2	1	63	1	0	0	0	0	0	0	0	1	9625	1281	45	1		1	MLLT1	19	6270699	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	814895	6270699	52858284	457	18852										
FBN3	84467	broad.mit.edu	37	chr19	8171100	8171100	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgacacagccctggcagctCttggcactcgtcgatgtctg	11	14	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:8171100C>G	uc002mjf.2	-	37	4726	c.4705G>C	c.(4705-4707)GAG>CAG	p.E1569Q		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1569	EGF-like 24; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCTGGCAGCTCTTGGCACTCG	0.577													0	0	0	0.00308	0	7	56										G	8171100	C	G	8171100	3	3	63	1	0	0	0	0	1	0	0	0	5704	922	32	1	3832	1	FBN3	19	8171100	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1900401	8171100	50957883	458	18853										
MUC16	94025	broad.mit.edu	37	chr19	9025598	9025598	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tctaagttctcacctgagcaAggtcaatctgcagccagagt	9	11	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:9025598A>G	uc002mkp.2	-	15	37060	c.36856T>C	c.(36856-36858)TTG>CTG	p.L12286L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12288	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACCTGAGCAAGGTCAATCTG	0.527													0	0	0	0.00278	0	21	115										G	9025598	A	G	9025598	2	3	63	1	0	0	0	0	0	0	0	1	9973	69	3	5		5	MUC16	19	9025598	Silent	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	854498	9025598	50103385	459	18854										
MRPL4	51073	broad.mit.edu	37	chr19	10369342	10369342	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acctctaggcttaagaccttCaacttgatcccggctgttgg	9	12	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:10369342C>T	uc002mnm.2	+	9	874	c.720C>T	c.(718-720)TTC>TTT	p.F240F	MRPL4_uc002mnn.2_Silent_p.F240F|MRPL4_uc002mno.2_Silent_p.F240F	NM_146387	NP_666499	Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4 isoform a	240					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		TTAAGACCTTCAACTTGATCC	0.567													0	0	0	0.00308	0	7	95										T	10369342	C	T	10369342	2	4	63	1	0	0	0	0	0	0	0	1	9803	825	29	1		1	MRPL4	19	10369342	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1343744	10369342	48759641	460	18855										
DOCK6	57572	broad.mit.edu	37	chr19	11323951	11323951	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccacagtgtcgtaggagcctCaggcacaggtcggcacacag	13	13	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:11323951C>T	uc002mqs.3	-	35	4433	c.4392G>A	c.(4390-4392)CTG>CTA	p.L1464L	DOCK6_uc010xlq.1_Silent_p.L803L	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1464					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GTAGGAGCCTCAGGCACAGGT	0.647													0	0	0	0.001984	0	6	28										T	11323951	C	T	11323951	2	4	63	1	0	0	0	0	0	0	0	1	4691	813	29	1		1	DOCK6	19	11323951	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	954609	11323951	47805032	461	18856										
MAST1	22983	broad.mit.edu	37	chr19	12985238	12985238	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggaacacgagacaggccggCgcagcagctctggcgaggcg	17	12	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:12985238C>T	uc002mvm.2	+	26	4395	c.4267C>T	c.(4267-4269)CGC>TGC	p.R1423C		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	1423					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GACAGGCCGGCGCAGCAGCTC	0.711													0	0	0	0.00308	0	7	30										T	12985238	C	T	12985238	3	4	63	1	0	0	0	0	1	0	0	0	9324	768	27	2	4369	2	MAST1	19	12985238	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1661287	12985238	46143745	462	18857										
NWD1	284434	broad.mit.edu	37	chr19	16908608	16908608	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttcgccgattcatggccatgGatctggaacatgaagacatg	11	9	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:16908608G>A	uc002neu.3	+	16	3792	c.3370G>A	c.(3370-3372)GAT>AAT	p.D1124N	NWD1_uc002net.3_Missense_Mutation_p.D989N|NWD1_uc002nev.3_Missense_Mutation_p.D918N			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1124							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CATGGCCATGGATCTGGAACA	0.537													0	0	0	0.00333	0	23	221										A	16908608	G	A	16908608	3	1	63	1	0	0	0	0	1	0	0	0	10781	1174	41	1	3011	1	NWD1	19	16908608	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3923370	16908608	42220375	463	18858										
PGPEP1	54858	broad.mit.edu	37	chr19	18466806	18466806	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctcatccccgccctgtgggaGaagcacagtccacaggtgag	12	14	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:18466806G>C	uc002nis.1	+	3	273	c.189G>C	c.(187-189)GAG>GAC	p.E63D	PGPEP1_uc002nir.1_RNA|PGPEP1_uc002nit.1_5'UTR|PGPEP1_uc010xqg.1_5'UTR	NM_017712	NP_060182	Q9NXJ5	PGPI_HUMAN	pyroglutamyl-peptidase I	63							cysteine-type peptidase activity				0						CCCTGTGGGAGAAGCACAGTC	0.567													0	0	0	0.001984	0	5	100										C	18466806	G	C	18466806	3	2	63	1	0	0	0	0	1	0	0	0	11803	933	33	1	199	1	PGPEP1	19	18466806	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1558198	18466806	40662177	464	18859										
CILP2	148113	broad.mit.edu	37	chr19	19655890	19655890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggacaggctggggtaccgtCggacggaccacgacgatccc	15	13	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:19655890C>T	uc002nmv.3	+	8	2621	c.2536C>T	c.(2536-2538)CGG>TGG	p.R846W	CILP2_uc002nmw.3_Missense_Mutation_p.R852W	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	846						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GGGGTACCGTCGGACGGACCA	0.706													0	0	0	0.000602	0	4	27										T	19655890	C	T	19655890	3	4	63	1	0	0	0	0	1	0	0	0	3430	875	31	1	2566	1	CILP2	19	19655890	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1189084	19655890	39473093	465	18860										
ZNF99	7652	broad.mit.edu	37	chr19	22952087	22952087	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	caggcattgccactcctccaGagcgaattctatggtcacat	8	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:22952087G>C	uc010xrh.1	-	2	106	c.106C>G	c.(106-108)CTG>GTG	p.L36V		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CACTCCTCCAGAGCGAATTCT	0.403													0	0	0	0.013537	0	11	99										C	22952087	G	C	22952087	3	2	63	1	0	0	0	0	1	0	0	0	18201	933	33	1	3030	1	ZNF99	19	22952087	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	3296197	22952087	36176896	466	18861										
CCDC123	84902	broad.mit.edu	37	chr19	33444672	33444672	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtgtttcaaaggatggcaaaGaagatcttcttcccatctca	8	9	4	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:33444672G>A	uc002nty.2	-	4	430	c.341C>T	c.(340-342)TCT>TTT	p.S114F	CCDC123_uc002ntx.2_5'UTR|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Missense_Mutation_p.S114F|CCDC123_uc002nua.2_Missense_Mutation_p.S114F|CCDC123_uc002nub.1_Missense_Mutation_p.S6F	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	114						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					GGATGGCAAAGAAGATCTTCT	0.443													0	0	0	0.007413	0	9	91										A	33444672	G	A	33444672	3	1	63	1	0	0	0	0	1	0	0	0	2759	942	33	1	2074	1	CCDC123	19	33444672	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	10492585	33444672	25684311	467	18862										
MLL4	9757	broad.mit.edu	37	chr19	36223466	36223466	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggactgagcccttccaggaaGagattgtagccgctggggcc	15	11	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:36223466G>C	uc010eei.2	+	29	6016	c.6016G>C	c.(6016-6018)GAG>CAG	p.E2006Q		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2006					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTTCCAGGAAGAGATTGTAGC	0.667													0	0	0	0.004482	0	8	41										C	36223466	G	C	36223466	3	2	63	1	0	0	0	0	1	0	0	0	9623	943	33	1	6126	1	MLL4	19	36223466	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2778794	36223466	22905517	468	18863										
C19orf55	148137	broad.mit.edu	37	chr19	36255947	36255949	+	In_Frame_Del	DEL	CTC	CTC	-													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccctgcagcaaagcctccatCtcctcctcctcctccctcag							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:36255947_36255949delCTC	uc002obq.1	+	7	712_714	c.639_641delCTC	c.(637-642)ATCTCC>ATC	p.S218del		NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137	218	Ser-rich.									ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGCCTCCATCTCCTCCTCCTCC	0.631																		8	402	---	---								-	36255949	CTC	-	36255947	7	5	63	1	0	1	0	1	0	0	0	0	1937	903	32	0	665	0	C19orf55	19	36255947	In_Frame_Del	DEL	CTC	TCGA-DK-A3IU-01A-11D-A20D-08	32481	36255947	22873036	469	18864										
ZNF568	374900	broad.mit.edu	37	chr19	37441804	37441804	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtgagaagtcacacaggggaGaaaccctatgaatgtaataa	11	6	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:37441804G>A	uc002ofc.2	+	7	2264	c.1749G>A	c.(1747-1749)GAG>GAA	p.E583E	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Silent_p.E507E|ZNF568_uc010efe.2_Silent_p.E507E|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACACAGGGGAGAAACCCTATG	0.378													0	0	0	0.001168	0	5	93										A	37441804	G	A	37441804	2	1	63	1	0	0	0	0	0	0	0	1	17996	933	33	1		1	ZNF568	19	37441804	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1185857	37441804	21687179	470	18865										
PAF1	54623	broad.mit.edu	37	chr19	39880314	39880314	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cggtaggtgtcaggattgatGagatcgatggtgacccccag	15	8	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:39880314G>A	uc002old.2	-	4	433	c.258C>T	c.(256-258)CTC>CTT	p.L86L	PAF1_uc002ole.1_Silent_p.L76L|PAF1_uc010xuv.1_Intron|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	86					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CAGGATTGATGAGATCGATGG	0.572													0	0	0	0.00308	0	7	96										A	39880314	G	A	39880314	2	1	63	1	0	0	0	0	0	0	0	1	11383	1277	45	1		1	PAF1	19	39880314	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	2438510	39880314	19248669	471	18866										
MIA	8190	broad.mit.edu	37	chr19	41281508	41281508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtctgccttctccggacctGgtgtcaggggtggtcctatg	14	11	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:41281508G>A	uc002opb.3	+	1	209	c.61G>A	c.(61-63)GGT>AGT	p.G21S	MIA_uc010xvt.1_RNA|RAB4B_uc002opc.1_5'Flank|RAB4B_uc002opd.1_5'Flank|RAB4B_uc002ope.1_5'Flank|EGLN2_uc010ehd.2_5'Flank	NM_006533	NP_006524	Q16674	MIA_HUMAN	melanoma inhibitory activity precursor	21					cell proliferation	extracellular space	growth factor activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)	GBM - Glioblastoma multiforme(1328;0.0199)		CTCCGGACCTGGTGTCAGGGG	0.622													0	0	0	0.006214	0	8	194										A	41281508	G	A	41281508	3	1	63	1	0	0	0	0	1	0	0	0	9563	1348	47	2	63	2	MIA	19	41281508	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1401194	41281508	17847475	472	18867										
ARHGEF1	9138	broad.mit.edu	37	chr19	42392170	42392170	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggagatggaagacttcgcccGaggggcggtgagtggacaga	19	7	0	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:42392170G>C	uc002orx.2	+	2	126	c.17G>C	c.(16-18)CGA>CCA	p.R6P	ARHGEF1_uc002orw.1_Missense_Mutation_p.R6P|ARHGEF1_uc002ory.2_Missense_Mutation_p.R6P|ARHGEF1_uc002orz.2_5'UTR|ARHGEF1_uc002osa.2_Missense_Mutation_p.R21P|ARHGEF1_uc002osb.2_Missense_Mutation_p.R21P	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	6					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GACTTCGCCCGAGGGGCGGTG	0.657													0	0	0	0.000602	0	4	24										C	42392170	G	C	42392170	3	2	63	1	0	0	0	0	1	0	0	0	893	1058	37	1	68	1	ARHGEF1	19	42392170	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1110662	42392170	16736813	473	18868										
ATP1A3	478	broad.mit.edu	37	chr19	42474362	42474362	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgcccgtaggccatgctgatGagtctctcattgaccaattt	9	11	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:42474362G>C	uc002osg.2	-	18	2671	c.2517C>G	c.(2515-2517)CTC>CTG	p.L839L	ATP1A3_uc010xwf.1_Silent_p.L850L|ATP1A3_uc010xwg.1_Silent_p.L809L|ATP1A3_uc010xwh.1_Silent_p.L852L|ATP1A3_uc002osh.2_Silent_p.L839L	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	839	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						CCATGCTGATGAGTCTCTCAT	0.612													0	0	0	0.00308	0	7	66										C	42474362	G	C	42474362	2	2	63	1	0	0	0	0	0	0	0	1	1130	1277	45	1		1	ATP1A3	19	42474362	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	82192	42474362	16654621	474	18869										
ZNF526	116115	broad.mit.edu	37	chr19	42728808	42728808	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agcacatgcttgctgtctcaGaggaggaggcactgaccaca	12	11	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:42728808G>A	uc002osz.1	+	3	409	c.253G>A	c.(253-255)GAG>AAG	p.E85K		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				TGCTGTCTCAGAGGAGGAGGC	0.582													0	0	0	0.004482	0	9	55										A	42728808	G	A	42728808	3	1	63	1	0	0	0	0	1	0	0	0	17964	943	33	1	255	1	ZNF526	19	42728808	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	254446	42728808	16400175	475	18870										
ZNF404	342908	broad.mit.edu	37	chr19	44377405	44377405	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atgaggtttctcaccagtatGacttctttgatgttcaacaa	7	8	3	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:44377405G>A	uc002oxs.3	-	2	961	c.952C>T	c.(952-954)CAT>TAT	p.H318Y		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	321	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TCACCAGTATGACTTCTTTGA	0.373													0	0	0	0.001168	0	5	50										A	44377405	G	A	44377405	3	1	63	1	0	0	0	0	1	0	0	0	17883	1290	45	1	701	1	ZNF404	19	44377405	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1648597	44377405	14751578	476	18871										
ZNF155	7711	broad.mit.edu	37	chr19	44500376	44500376	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	actctatcataaataactctCagttctttgaaaatggtgat	5	7	4	2	rs138952990		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:44500376C>G	uc002oxy.1	+	5	572	c.367C>G	c.(367-369)CAG>GAG	p.Q123E	ZNF155_uc002oxz.1_Missense_Mutation_p.Q123E|ZNF155_uc010xwt.1_Missense_Mutation_p.Q134E	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	123						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				AAATAACTCTCAGTTCTTTGA	0.463													0	0	0	0.001984	0	7	100										G	44500376	C	G	44500376	3	3	63	1	0	0	0	0	1	0	0	0	17733	827	29	1	381	1	ZNF155	19	44500376	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	122971	44500376	14628607	477	18872										
IRF2BP1	26145	broad.mit.edu	37	chr19	46387392	46387392	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agcgggcacttgtctccgctCgggcagtacacctccccggc	12	17	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:46387392C>T	uc002pds.1	-	1	1985	c.1641G>A	c.(1639-1641)CCG>CCA	p.P547P		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	547	Cys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		TGTCTCCGCTCGGGCAGTACA	0.637													0	0	0	0.001168	0	4	37										T	46387392	C	T	46387392	2	4	63	1	0	0	0	0	0	0	0	1	7829	871	31	1		1	IRF2BP1	19	46387392	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1887016	46387392	12741591	478	18873										
TSKS	60385	broad.mit.edu	37	chr19	50243088	50243088	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggttcctgcactgctgcctCcccccattgttcccgtggac	10	17	0	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:50243088C>A	uc002ppm.2	-	11	1735	c.1724G>T	c.(1723-1725)GGA>GTA	p.G575V		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	575							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACTGCTGCCTCCCCCCATTGT	0.552													1	0	0.000219431	0.00245	0.000228178	13	102										A	50243088	C	A	50243088	3	1	63	1	0	0	0	0	1	0	0	0	16623	855	30	3	58	3	TSKS	19	50243088	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	3855696	50243088	8885895	479	18874										
ZNF528	84436	broad.mit.edu	37	chr19	52909217	52909217	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctcaggaagagtggaaatgcCtggaccctgcgcagaggact	14	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:52909217C>A	uc002pzh.2	+	5	499	c.73C>A	c.(73-75)CTG>ATG	p.L25M	ZNF528_uc002pzi.2_Translation_Start_Site	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GTGGAAATGCCTGGACCCTGC	0.488													1	0	8.69298e-16	0.006999	9.57025e-16	42	145										A	52909217	C	A	52909217	3	1	63	1	0	0	0	0	1	0	0	0	17966	680	24	4	79	4	ZNF528	19	52909217	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2666129	52909217	6219766	480	18875										
C19orf51	352909	broad.mit.edu	37	chr19	55672075	55672075	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggtcccccccggtggctctCgcgcgcccccaggcggccac	13	21	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:55672075C>T	uc002qji.1	-	9	1015	c.981G>A	c.(979-981)GCG>GCA	p.A327A	TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Silent_p.A142A|C19orf51_uc002qjj.1_Silent_p.A374A|C19orf51_uc002qjk.1_Silent_p.A273A|C19orf51_uc002qjl.1_Silent_p.A395A			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	327											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CGGTGGCTCTCGCGCGCCCCC	0.682											OREG0025678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	61										T	55672075	C	T	55672075	2	4	63	1	0	0	0	0	0	0	0	1	1933	871	31	1		1	C19orf51	19	55672075	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2762858	55672075	3456908	481	18876										
NLRP8	126205	broad.mit.edu	37	chr19	56466276	56466276	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cccgaccaacttctgctgctCttggatggctttgaggagct	11	12	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:56466276C>G	uc002qmh.2	+	3	923	c.852C>G	c.(850-852)CTC>CTG	p.L284L	NLRP8_uc010etg.2_Silent_p.L284L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	284	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTCTGCTGCTCTTGGATGGCT	0.522													0	0	0	0.008361	0	26	183										G	56466276	C	G	56466276	2	3	63	1	0	0	0	0	0	0	0	1	10483	900	32	1		1	NLRP8	19	56466276	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	794201	56466276	2662707	482	18877										
PEG3	5178	broad.mit.edu	37	chr19	57328268	57328268	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gccaaggcggcactcttattGaaggtctctccacagtcctt	9	13	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:57328268G>A	uc002qnu.2	-	7	1893	c.1542C>T	c.(1540-1542)TTC>TTT	p.F514F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.F485F|PEG3_uc002qnv.2_Silent_p.F514F|PEG3_uc002qnw.2_Silent_p.F390F|PEG3_uc002qnx.2_Silent_p.F388F|PEG3_uc010etr.2_Silent_p.F514F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	514	C2H2-type 2.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CACTCTTATTGAAGGTCTCTC	0.458													0	0	0	0.008361	0	25	105										A	57328268	G	A	57328268	2	1	63	1	0	0	0	0	0	0	0	1	11720	1281	45	1		1	PEG3	19	57328268	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	861992	57328268	1800715	483	18878										
ZNF543	125919	broad.mit.edu	37	chr19	57840469	57840469	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtggaaaggcttttaatcgcGgctcatccctcacacatcat	8	12	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:57840469G>A	uc002qoi.1	+	4	1984	c.1639G>A	c.(1639-1641)GGC>AGC	p.G547S		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	547	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTTTAATCGCGGCTCATCCCT	0.463													0	0	0	0.001984	0	5	74										A	57840469	G	A	57840469	3	1	63	1	0	0	0	0	1	0	0	0	17973	1116	39	2	1653	2	ZNF543	19	57840469	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	512201	57840469	1288514	484	18879										
ZNF749	388567	broad.mit.edu	37	chr19	57956103	57956104	+	Missense_Mutation	DNP	TG	TG	CC													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagtcccacctagttcagcaTgagaaaatccacactgatgc							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:57956103_57956104TG>CC	uc002qoq.2	+	3	1841_1842	c.1587_1588TG>CC	c.(1585-1590)CATGAG>CACCAG	p.E530Q	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	530	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TAGTTCAGCATGAGAAAATCCA	0.45													0	0	0	0.004672	0	3	89										CC	57956104	TG	CC	57956103	3	2	63	1	0	0	0	0	1	0	0	0	18128	1461	51	5	1597	5	ZNF749	19	57956103	Missense_Mutation	DNP	TG	TCGA-DK-A3IU-01A-11D-A20D-08	115634	57956103	1172880	485	18880										
RBCK1	10616	broad.mit.edu	37	chr20	401519	401521	+	In_Frame_Del	DEL	AGC	AGC	-													0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cgccccgtgtgcccagcggaAgcagcagcagcaggagggga							TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:401519_401521delAGC	uc002wdp.3	+	7	1454_1456	c.761_763delAGC	c.(760-765)AAGCAG>AAG	p.Q258del	RBCK1_uc010zpm.1_Intron|RBCK1_uc002wdq.3_In_Frame_Del_p.Q216del|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Intron	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	258	Potential.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				GCCCAGCGGAAGCAGCAGCAGCA	0.729																		2	4	---	---								-	401521	AGC	-	401519	7	5	63	1	0	1	0	1	0	0	0	0	13107	72	3	0	806	0	RBCK1	20	401519	In_Frame_Del	DEL	AGC	TCGA-DK-A3IU-01A-11D-A20D-08		401519	62624001	486	18881										
PLCB1	23236	broad.mit.edu	37	chr20	8696958	8696958	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtactgccgactgatctttgGggatgcccttctcatggagc	12	11	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:8696958G>C	uc002wnb.2	+	13	1301	c.1298G>C	c.(1297-1299)GGG>GCG	p.G433A	PLCB1_uc010zrb.1_Missense_Mutation_p.G332A|PLCB1_uc002wna.2_Missense_Mutation_p.G433A|PLCB1_uc002wnc.1_Missense_Mutation_p.G332A|PLCB1_uc002wnd.1_Missense_Mutation_p.G10A	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	433	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGATCTTTGGGGATGCCCTT	0.468													0	0	0	0.004482	0	8	40										C	8696958	G	C	8696958	3	2	63	1	0	0	0	0	1	0	0	0	12027	1232	43	4	1348	4	PLCB1	20	8696958	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8295439	8696958	54328562	487	18882										
JAG1	182	broad.mit.edu	37	chr20	10620148	10620148	+	Nonstop_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ggcagtgcccgcggtctgctAtacgatgtactccattcggt	12	12	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:10620148A>G	uc002wnw.2	-	26	4171	c.3655T>C	c.(3655-3657)TAG>CAG	p.*1219Q		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	1219					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GCGGTCTGCTATACGATGTAC	0.522									Alagille_Syndrome				0	0	0	0.008871	0	18	178										G	10620148	A	G	10620148	4	3	63	1	0	0	0	0	0	0	0	0	7934	462	16	5	5	5	JAG1	20	10620148	Nonstop_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	1923190	10620148	52405372	488	18883										
CRNKL1	51340	broad.mit.edu	37	chr20	20022983	20022983	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tttcacctttgcctccaattCttcatagagtgcatagttga	6	10	3	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:20022983C>T	uc002wrs.2	-	9	1665	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	545					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						GCCTCCAATTCTTCATAGAGT	0.413													0	0	0	0.008291	0	9	92										T	20022983	C	T	20022983	3	4	63	1	0	0	0	0	1	0	0	0	3891	922	32	1	941	1	CRNKL1	20	20022983	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	9402835	20022983	43002537	489	18884										
MYH7B	57644	broad.mit.edu	37	chr20	33577919	33577919	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agaataggctcctggcgactCtctatgagaattatgcgggc	12	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:33577919C>G	uc002xbi.1	+	19	2088	c.1996C>G	c.(1996-1998)CTC>GTC	p.L666V	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	624	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCTGGCGACTCTCTATGAGAA	0.552													0	0	0	0.008291	0	11	134										G	33577919	C	G	33577919	3	3	63	1	0	0	0	0	1	0	0	0	10040	913	32	1	2070	1	MYH7B	20	33577919	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	13554936	33577919	29447601	490	18885										
KIAA0406	9675	broad.mit.edu	37	chr20	36641489	36641489	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttcatcagccataatgaagcTcactgtcttgtaaaagatct	6	9	5	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:36641489T>C	uc002xhl.2	-	3	939	c.730A>G	c.(730-732)AGC>GGC	p.S244G	KIAA0406_uc002xhm.2_Missense_Mutation_p.S244G	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	244							binding				0		Myeloproliferative disorder(115;0.00874)				ATAATGAAGCTCACTGTCTTG	0.443													0	0	0	0.00245	0	12	150										C	36641489	T	C	36641489	3	2	63	1	0	0	0	0	1	0	0	0	8173	1551	54	5	2567	5	KIAA0406	20	36641489	Missense_Mutation	SNP	T	TCGA-DK-A3IU-01A-11D-A20D-08	3063570	36641489	26384031	491	18886										
SPINT4	391253	broad.mit.edu	37	chr20	44352659	44352659	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acaacttcaagcttaaaataGaacgtgaagtagcctgtgtt	8	7	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:44352659G>C	uc002xpe.1	+	2	275	c.256G>C	c.(256-258)GAA>CAA	p.E86Q		NM_178455	NP_848550	Q6UDR6	SPIT4_HUMAN	serine peptidase inhibitor, Kunitz type 4	86	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2		Myeloproliferative disorder(115;0.028)				GCTTAAAATAGAACGTGAAGT	0.393													0	0	0	0.006214	0	7	122										C	44352659	G	C	44352659	3	2	63	1	0	0	0	0	1	0	0	0	15069	943	33	1	262	1	SPINT4	20	44352659	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	7711170	44352659	18672861	492	18887										
NCOA3	8202	broad.mit.edu	37	chr20	46279914	46279914	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cagcagcaaacccaggccttCagcccacctcctaatgtgac	7	17	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:46279914C>T	uc002xtk.2	+	20	4045	c.3840C>T	c.(3838-3840)TTC>TTT	p.F1280F	NCOA3_uc010ght.1_Silent_p.F1271F|NCOA3_uc002xtl.2_Silent_p.F1276F|NCOA3_uc002xtm.2_Silent_p.F1275F|NCOA3_uc002xtn.2_Silent_p.F1279F|NCOA3_uc010zyc.1_Silent_p.F1075F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1280	Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CCCAGGCCTTCAGCCCACCTC	0.308													0	0	0	0.009096	0	4	61										T	46279914	C	T	46279914	2	4	63	1	0	0	0	0	0	0	0	1	10230	825	29	1		1	NCOA3	20	46279914	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1927255	46279914	16745606	493	18888										
ARFGEF2	10564	broad.mit.edu	37	chr20	47605103	47605103	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atagtaaagatctgccagaaGagtatctctcaagcatctat	7	8	4	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:47605103G>A	uc002xtx.3	+	18	2589	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	ARFGEF2_uc010zyf.1_Missense_Mutation_p.E106K	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	813					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCTGCCAGAAGAGTATCTCTC	0.313													0	0	0	0.00308	0	8	153										A	47605103	G	A	47605103	3	1	63	1	0	0	0	0	1	0	0	0	853	943	33	1	2507	1	ARFGEF2	20	47605103	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1325189	47605103	15420417	494	18889										
PTGIS	5740	broad.mit.edu	37	chr20	48124546	48124546	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gaggtcaaactcagggatctCcacatctgcgttgatcagct	10	11	5	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:48124546C>G	uc002xut.2	-	10	1468	c.1414G>C	c.(1414-1416)GAG>CAG	p.E472Q	PTGIS_uc010zyi.1_Missense_Mutation_p.E333Q	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	472					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TCAGGGATCTCCACATCTGCG	0.572													0	0	0	0.008291	0	10	72										G	48124546	C	G	48124546	3	3	63	1	0	0	0	0	1	0	0	0	12752	864	30	1	92	1	PTGIS	20	48124546	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	519443	48124546	14900974	495	18890										
SALL4	57167	broad.mit.edu	37	chr20	50401158	50401158	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cctaacagagccatggtgttCtcgatggccaacttccttcc	8	14	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:50401158C>G	uc002xwh.3	-	4	2909	c.2808G>C	c.(2806-2808)GAG>GAC	p.E936D	SALL4_uc010gii.2_Missense_Mutation_p.E499D|SALL4_uc002xwi.3_Missense_Mutation_p.E159D	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	936					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCATGGTGTTCTCGATGGCCA	0.493													0	0	0	0.004482	0	8	94										G	50401158	C	G	50401158	3	3	63	1	0	0	0	0	1	0	0	0	13813	912	32	1	357	1	SALL4	20	50401158	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2276612	50401158	12624362	496	18891										
ZFP64	55734	broad.mit.edu	37	chr20	50768754	50768754	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccttgaatgatggagtaggtCtgcttgggtagttcttgctg	14	6	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:50768754C>T	uc002xwl.2	-	6	2326	c.1977G>A	c.(1975-1977)CAG>CAA	p.Q659Q	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Silent_p.Q657Q|ZFP64_uc002xwn.2_Silent_p.Q605Q	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGAGTAGGTCTGCTTGGGTA	0.547													0	0	0	0.001168	0	4	126										T	50768754	C	T	50768754	2	4	63	1	0	0	0	0	0	0	0	1	17649	912	32	1		1	ZFP64	20	50768754	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	367596	50768754	12256766	497	18892										
TAF4	6874	broad.mit.edu	37	chr20	60578285	60578285	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ctgcttgtgccgagacagcaGaaagggctttggttccaggt	14	9	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:60578285G>A	uc002ybs.2	-	9	2417	c.2417C>T	c.(2416-2418)TCT>TTT	p.S806F		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	806					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CGAGACAGCAGAAAGGGCTTT	0.493													0	0	0	0.00308	0	7	111										A	60578285	G	A	60578285	3	1	63	1	0	0	0	0	1	0	0	0	15523	942	33	1	868	1	TAF4	20	60578285	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	9809531	60578285	2447235	498	18893										
EEF1A2	1917	broad.mit.edu	37	chr20	62120317	62120317	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tccacacacatgggctttccCggcaccatctccacgatggc	8	17	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62120317C>A	uc002yfd.1	-	6	1319	c.1218G>T	c.(1216-1218)CCG>CCT	p.P406P	EEF1A2_uc002yfe.1_Silent_p.P406P|EEF1A2_uc010gkg.1_Intron	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	406						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TGGGCTTTCCCGGCACCATCT	0.647													1	0	6.40141e-05	0.010729	6.70305e-05	10	72										A	62120317	C	A	62120317	2	1	63	1	0	0	0	0	0	0	0	1	4924	639	23	4		4	EEF1A2	20	62120317	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1542032	62120317	905203	499	18894										
TPD52L2	7165	broad.mit.edu	37	chr20	62500783	62500783	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggaggaggagctcagggctGagcttaccaaggtgctgtgg	18	7	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62500783G>C	uc002yhc.2	+	2	283	c.154G>C	c.(154-156)GAG>CAG	p.E52Q	TPD52L2_uc002ygy.2_Missense_Mutation_p.E52Q|TPD52L2_uc002ygz.2_Missense_Mutation_p.E52Q|TPD52L2_uc002yha.2_Missense_Mutation_p.E52Q|TPD52L2_uc002yhb.2_Missense_Mutation_p.E52Q|TPD52L2_uc002yhd.2_Missense_Mutation_p.E52Q|TPD52L2_uc011abk.1_Intron|TPD52L2_uc011abl.1_Missense_Mutation_p.E29Q	NM_003288	NP_003279	O43399	TPD54_HUMAN	tumor protein D52-like 2 isoform e	52	Potential.				regulation of cell proliferation	perinuclear region of cytoplasm	protein binding|protein homodimerization activity			ovary(1)|skin(1)	2	all_cancers(38;1.3e-12)|all_epithelial(29;2.23e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					GCTCAGGGCTGAGCTTACCAA	0.597													0	0	0	0.004482	0	6	78										C	62500783	G	C	62500783	3	2	63	1	0	0	0	0	1	0	0	0	16396	1291	45	1	160	1	TPD52L2	20	62500783	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	380466	62500783	524737	500	18895										
PRPF6	24148	broad.mit.edu	37	chr20	62659889	62659889	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	agaacatcgcaaatacactcAtggccaaggcgctgcaggag	11	11	1	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62659889A>T	uc002yho.2	+	18	2566	c.2398A>T	c.(2398-2400)ATG>TTG	p.M800L	PRPF6_uc002yhp.2_Missense_Mutation_p.M760L	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	800					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					AAATACACTCATGGCCAAGGC	0.652													0	0	0	0.013537	0	11	122										T	62659889	A	T	62659889	3	4	63	1	0	0	0	0	1	0	0	0	12574	217	8	5	2468	5	PRPF6	20	62659889	Missense_Mutation	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	159106	62659889	365631	501	18896										
PCMTD2	55251	broad.mit.edu	37	chr20	62896743	62896743	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gagtacatgaagaatcttctCaaagtgggagggatccttgt	12	6	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62896743C>T	uc002yil.3	+	4	743	c.543C>T	c.(541-543)CTC>CTT	p.L181L	PCMTD2_uc002yim.3_Silent_p.L181L	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	181						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGAATCTTCTCAAAGTGGGAG	0.368													0	0	0	0.006214	0	8	107										T	62896743	C	T	62896743	2	4	63	1	0	0	0	0	0	0	0	1	11587	813	29	1		1	PCMTD2	20	62896743	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	236854	62896743	128777	502	18897										
C21orf29	54084	broad.mit.edu	37	chr21	45950980	45950980	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	acgaagaatcgagctcctttCactgacagggtggctgggaa	13	9	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr21:45950980C>T	uc002zfe.1	-	4	645	c.579G>A	c.(577-579)GTG>GTA	p.V193V	C21orf29_uc010gpv.1_Silent_p.V125V	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	193	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity				0						GAGCTCCTTTCACTGACAGGG	0.567													0	0	0	0.000602	0	4	44										T	45950980	C	T	45950980	2	4	63	1	0	0	0	0	0	0	0	1	2124	813	29	1		1	C21orf29	21	45950980	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		45950980	2178915	503	18898										
MRPL40	64976	broad.mit.edu	37	chr22	19422269	19422269	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tatctattagatcagaacctCttcgaaaaaagaagaaggta	7	6	3	4			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:19422269C>T	uc002zpg.2	+	3	190	c.148C>T	c.(148-150)CTT>TTT	p.L50F	HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zph.2_Missense_Mutation_p.L6F	NM_003776	NP_003767	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40 precursor	50					anatomical structure morphogenesis	mitochondrial ribosome|nucleus					0	Colorectal(54;0.0993)					ATCAGAACCTCTTCGAAAAAA	0.383													0	0	0	0.004672	0	3	22										T	19422269	C	T	19422269	3	4	63	1	0	0	0	0	1	0	0	0	9804	913	32	1	158	1	MRPL40	22	19422269	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		19422269	31882297	504	18899										
GGT1	2678	broad.mit.edu	37	chr22	25023891	25023891	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	atggacgacttcagctctccCagcatcaccaacgagtttgg	9	13	3	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:25023891C>A	uc003aan.1	+	13	1768	c.1281C>A	c.(1279-1281)CCC>CCA	p.P427P	GGT1_uc003aas.1_Silent_p.P427P|GGT1_uc003aat.1_Silent_p.P427P|GGT1_uc003aau.1_Silent_p.P427P|GGT1_uc003aav.1_Silent_p.P427P|GGT1_uc003aaw.1_Silent_p.P427P|GGT1_uc003aax.1_Silent_p.P427P|GGT1_uc003aay.1_Silent_p.P83P	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	427	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	TCAGCTCTCCCAGCATCACCA	0.617													1	0	2.31682e-05	0.003163	2.43876e-05	12	201										A	25023891	C	A	25023891	2	1	63	1	0	0	0	0	0	0	0	1	6361	581	21	4		4	GGT1	22	25023891	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5601622	25023891	26280675	505	18900										
MYO18B	84700	broad.mit.edu	37	chr22	26286783	26286783	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaggtgatgtggcctgccagGtgctggagagtgagcgggca	19	7	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:26286783G>A	uc003abz.1	+	26	4625	c.4375G>A	c.(4375-4377)GTG>ATG	p.V1459M	MYO18B_uc003aca.1_Missense_Mutation_p.V1340M|MYO18B_uc010guy.1_Missense_Mutation_p.V1341M|MYO18B_uc010guz.1_Missense_Mutation_p.V1340M|MYO18B_uc011aka.1_Missense_Mutation_p.V613M|MYO18B_uc011akb.1_Missense_Mutation_p.V972M	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1459	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGCCTGCCAGGTGCTGGAGAG	0.612													0	0	0	0.004482	0	7	37										A	26286783	G	A	26286783	3	1	63	1	0	0	0	0	1	0	0	0	10066	1261	44	2	4473	2	MYO18B	22	26286783	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1262892	26286783	25017783	506	18901										
HPS4	89781	broad.mit.edu	37	chr22	26860092	26860092	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcattccagaccaggggctgCgtggctttcacagaccccat	11	14	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:26860092C>T	uc003acl.2	-	11	2163	c.1504G>A	c.(1504-1506)GCA>ACA	p.A502T	HPS4_uc003aci.2_Missense_Mutation_p.A497T|HPS4_uc003acj.2_Missense_Mutation_p.A366T|HPS4_uc003ack.2_Missense_Mutation_p.A293T|HPS4_uc003acn.2_Missense_Mutation_p.A348T|HPS4_uc010gvd.1_Missense_Mutation_p.A520T|HPS4_uc003ach.2_Missense_Mutation_p.A237T	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	502					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						CCAGGGGCTGCGTGGCTTTCA	0.567									Hermansky-Pudlak_syndrome				0	0	0	0.004878	0	27	148										T	26860092	C	T	26860092	3	4	63	1	0	0	0	0	1	0	0	0	7341	768	27	2	638	2	HPS4	22	26860092	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	573309	26860092	24444474	507	18902										
DRG1	4733	broad.mit.edu	37	chr22	31822752	31822752	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tggaaaagatctgggactatCtgaaactagtgagaatgtaa	11	4	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:31822752C>G	uc003aku.2	+	7	996	c.865C>G	c.(865-867)CTG>GTG	p.L289V		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	289					multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1						CTGGGACTATCTGAAACTAGT	0.398													0	0	0	0.00499	0	13	104										G	31822752	C	G	31822752	3	3	63	1	0	0	0	0	1	0	0	0	4761	912	32	1	891	1	DRG1	22	31822752	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	4962660	31822752	19481814	508	18903										
SSTR3	6753	broad.mit.edu	37	chr22	37603237	37603237	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tagatgatgaagccggctcgCcaggccgccgccggctcggg	16	14	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:37603237C>T	uc003ara.2	-	2	668	c.606G>A	c.(604-606)TGG>TGA	p.W202*	SSTR3_uc003arb.2_Nonsense_Mutation_p.W202*	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	202	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						AGCCGGCTCGCCAGGCCGCCG	0.682													0	0	0	0.004672	0	3	16										T	37603237	C	T	37603237	4	4	63	1	0	0	0	0	0	1	0	0	15198	740	26	2	654	2	SSTR3	22	37603237	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	5780485	37603237	13701329	509	18904										
ELFN2	114794	broad.mit.edu	37	chr22	37771107	37771107	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aggcggttggaggacaggtcGatgctgatgaggctcgggca	19	7	0	2	rs150477054		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:37771107G>A	uc003asq.3	-	3	1254	c.468C>T	c.(466-468)ATC>ATT	p.I156I		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	156	LRR 5.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					AGGACAGGTCGATGCTGATGA	0.642													0	0	0	0.00308	0	7	86										A	37771107	G	A	37771107	2	1	63	1	0	0	0	0	0	0	0	1	5058	1048	37	1		1	ELFN2	22	37771107	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	167870	37771107	13533459	510	18905										
ENTHD1	150350	broad.mit.edu	37	chr22	40139965	40139965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tacattttgggtggaaaactCcccccagtgactactagaaa	8	10	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:40139965C>T	uc003ayg.2	-	7	1794	c.1543G>A	c.(1543-1545)GAG>AAG	p.E515K		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	515										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GTGGAAAACTCCCCCCAGTGA	0.413													0	0	0	0.009096	0	4	38										T	40139965	C	T	40139965	3	4	63	1	0	0	0	0	1	0	0	0	5137	864	30	1	284	1	ENTHD1	22	40139965	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	2368858	40139965	11164601	511	18906										
ACO2	50	broad.mit.edu	37	chr22	41911842	41911842	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gatgtgatcctgaaggtggcAggcatcctcacggtgaaagg	15	8	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:41911842A>T	uc003bac.2	+	6	778	c.756A>T	c.(754-756)GCA>GCT	p.A252A	ACO2_uc003bad.2_Silent_p.A252A	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	252					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						TGAAGGTGGCAGGCATCCTCA	0.612													0	0	0	0.004482	0	9	72										T	41911842	A	T	41911842	2	4	63	1	0	0	0	0	0	0	0	1	147	175	7	5		5	ACO2	22	41911842	Silent	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	1771877	41911842	9392724	512	18907										
CRELD2	79174	broad.mit.edu	37	chr22	50318084	50318084	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	tgtatctctggctacgcgagGgagcacggacagtgtgcagg	16	9	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:50318084G>A	uc003bja.2	+	8	984	c.849G>A	c.(847-849)AGG>AGA	p.R283R	CRELD2_uc010haj.2_Silent_p.R283R|CRELD2_uc010hal.2_Silent_p.R332R|CRELD2_uc010hak.2_Silent_p.R255R|CRELD2_uc010ham.2_Intron	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	283	FU 2.					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		GCTACGCGAGGGAGCACGGAC	0.597													0	0	0	0.000602	0	5	17										A	50318084	G	A	50318084	2	1	63	1	0	0	0	0	0	0	0	1	3867	1223	43	2		2	CRELD2	22	50318084	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	8406242	50318084	986482	513	18908										
SBF1	6305	broad.mit.edu	37	chr22	50898430	50898430	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	cggagaaatgcggaagggctCagacttggcccggctcaggc	16	11	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:50898430C>G	uc003blh.2	-	26	3637	c.3442G>C	c.(3442-3444)GAG>CAG	p.E1148Q	SBF1_uc011arx.1_Missense_Mutation_p.E812Q	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1148	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGGAAGGGCTCAGACTTGGCC	0.662													0	0	0	0.004482	0	7	63										G	50898430	C	G	50898430	3	3	63	1	0	0	0	0	1	0	0	0	13858	835	29	1	2303	1	SBF1	22	50898430	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	580346	50898430	406136	514	18909										
RPS6KA3	6197	broad.mit.edu	37	chrX	20194392	20194392	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggagtttttgcagtaaactCaggatcaaaatagaatgtat	10	4	2	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:20194392C>G	uc004czu.2	-	13	1078	c.1078G>C	c.(1078-1080)GAG>CAG	p.E360Q	RPS6KA3_uc011mjk.1_Missense_Mutation_p.E331Q|RPS6KA3_uc004czv.2_Missense_Mutation_p.E348Q|RPS6KA3_uc011mjl.1_Missense_Mutation_p.E332Q|RPS6KA3_uc011mjm.1_Missense_Mutation_p.E332Q	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	360	AGC-kinase C-terminal.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						GCAGTAAACTCAGGATCAAAA	0.348													0	0	0	0.000602	0	4	21										G	20194392	C	G	20194392	3	3	63	1	0	0	0	0	1	0	0	0	13652	835	29	1	1184	1	RPS6KA3	23	20194392	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08		20194392	135076168	515	18910										
TAB3	257397	broad.mit.edu	37	chrX	30872614	30872614	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttgattccatggagatggttGattactgatgggtgaaggac	14	4	0	5			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:30872614G>A	uc004dcj.2	-	6	1831	c.1168C>T	c.(1168-1170)CAA>TAA	p.Q390*	TAB3_uc004dck.2_Nonsense_Mutation_p.Q390*|TAB3_uc010ngl.2_Nonsense_Mutation_p.Q390*	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	390	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GGAGATGGTTGATTACTGATG	0.423													0	0	0	0.001168	0	4	73										A	30872614	G	A	30872614	4	1	63	1	0	0	0	0	0	1	0	0	15494	1299	45	1	994	1	TAB3	23	30872614	Nonsense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	10678222	30872614	124397946	516	18911										
BMP15	9210	broad.mit.edu	37	chrX	50659572	50659572	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gtattttgtacaaggagtatGagggtatgattgctgagtct	13	3	1	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:50659572G>A	uc011mnw.1	+	2	1144	c.1144G>A	c.(1144-1146)GAG>AAG	p.E382K		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	382					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					CAAGGAGTATGAGGGTATGAT	0.453													0	0	0	0.00308	0	7	63										A	50659572	G	A	50659572	3	1	63	1	0	0	0	0	1	0	0	0	1458	1291	45	1	1150	1	BMP15	23	50659572	Missense_Mutation	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	19786958	50659572	104610988	517	18912										
XAGE5	170627	broad.mit.edu	37	chrX	52844216	52844216	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gggaagattctgccaaaatcAgagcaatttaaaatgccaga	9	7	2	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:52844216A>C	uc004drd.1	+	4	344	c.279A>C	c.(277-279)TCA>TCC	p.S93S		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	93										ovary(1)	1						TGCCAAAATCAGAGCAATTTA	0.388													0	0	0	0.004482	0	7	22										C	52844216	A	C	52844216	2	2	63	1	0	0	0	0	0	0	0	1	17418	175	7	5		5	XAGE5	23	52844216	Silent	SNP	A	TCGA-DK-A3IU-01A-11D-A20D-08	2184644	52844216	102426344	518	18913										
HUWE1	10075	broad.mit.edu	37	chrX	53578272	53578272	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcagccagaaactcagggctCacttcagtcacaccaggatt	9	13	4	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:53578272C>G	uc004dsp.2	-	64	9453	c.9051G>C	c.(9049-9051)GTG>GTC	p.V3017V	HUWE1_uc004dsn.2_Intron	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3017					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ACTCAGGGCTCACTTCAGTCA	0.597													0	0	0	0.000602	0	4	9										G	53578272	C	G	53578272	2	3	63	1	0	0	0	0	0	0	0	1	7461	813	29	1		1	HUWE1	23	53578272	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	734056	53578272	101692288	519	18914										
RLIM	51132	broad.mit.edu	37	chrX	73814150	73814150	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ccaaaacatacctctattttCatctgagttttgcggtggtg	8	9	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:73814150C>T	uc004ebu.2	-	4	534	c.244G>A	c.(244-246)GAA>AAA	p.E82K	RLIM_uc004ebw.2_Missense_Mutation_p.E82K	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	82					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CCTCTATTTTCATCTGAGTTT	0.418													0	0	0	0.000602	0	5	29										T	73814150	C	T	73814150	3	4	63	1	0	0	0	0	1	0	0	0	13390	835	29	1	1638	1	RLIM	23	73814150	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	20235878	73814150	81456410	520	18915										
ABCB7	22	broad.mit.edu	37	chrX	74291394	74291394	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	ttatagctgttaaaccgacaCtgaaaatagcactttgacca	6	9	0	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:74291394C>A	uc004eca.2	-	9	1182	c.1157G>T	c.(1156-1158)AGT>ATT	p.S386I	ABCB7_uc004ebz.2_Missense_Mutation_p.S387I|ABCB7_uc011mqn.1_Missense_Mutation_p.S360I|ABCB7_uc010nls.2_Missense_Mutation_p.S347I|ABCB7_uc010nlt.2_Missense_Mutation_p.S346I	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	386	ABC transmembrane type-1.|Helical; (Potential).				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						TAAACCGACACTGAAAATAGC	0.408													1	0	0.00909568	0.009096	0.00928131	4	63										A	74291394	C	A	74291394	3	1	63	1	0	0	0	0	1	0	0	0	46	565	20	4	1133	4	ABCB7	23	74291394	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	477244	74291394	80979166	521	18916										
GPRASP1	9737	broad.mit.edu	37	chrX	101912847	101912847	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagagacaaatgacaatattCaaattgttcttgcaatattt	5	5	2	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:101912847C>T	uc004ejj.3	+	5	4807	c.4006C>T	c.(4006-4008)CAA>TAA	p.Q1336*	GPRASP1_uc004eji.3_Nonsense_Mutation_p.Q1336*|GPRASP1_uc010nod.2_Nonsense_Mutation_p.Q1336*	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1336	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TGACAATATTCAAATTGTTCT	0.328													0	0	0	0.004482	0	7	32										T	101912847	C	T	101912847	4	4	63	1	0	0	0	0	0	1	0	0	6722	827	29	1	4008	1	GPRASP1	23	101912847	Nonsense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	27621453	101912847	53357713	522	18917										
BEX4	56271	broad.mit.edu	37	chrX	102471435	102471435	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aaccattatgacttttgcctCataccttgaatcctaaaagt	4	10	1	2			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:102471435C>T	uc004ejv.3	+	3	589	c.354C>T	c.(352-354)CTC>CTT	p.L118L	BEX4_uc004ejw.3_Silent_p.L118L	NM_001080425	NP_001073894	Q9NWD9	BEX4_HUMAN	BEX family member 4	118						cytoplasm|nucleus				skin(1)	1						ACTTTTGCCTCATACCTTGAA	0.398													0	0	0	0.003163	0	13	58										T	102471435	C	T	102471435	2	4	63	1	0	0	0	0	0	0	0	1	1412	813	29	1		1	BEX4	23	102471435	Silent	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	558588	102471435	52799125	523	18918										
ESX1	80712	broad.mit.edu	37	chrX	103499470	103499470	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	attcacttcctcgatgtcctCgccgactgccaggctgcggt	10	15	1	0			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:103499470C>T	uc004ely.2	-	1	119	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	21					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCGATGTCCTCGCCGACTGCC	0.552													0	0	0	0.008291	0	7	157										T	103499470	C	T	103499470	3	4	63	1	0	0	0	0	1	0	0	0	5263	893	31	1	1175	1	ESX1	23	103499470	Missense_Mutation	SNP	C	TCGA-DK-A3IU-01A-11D-A20D-08	1028035	103499470	51771090	524	18919										
SERPINA7	6906	broad.mit.edu	37	chrX	105281023	105281023	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	gcatgaagcccaagtaccaaGagaaccagatacaggaatgg	11	9	0	3			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:105281023G>C	uc004eme.1	-	1	43	c.27C>G	c.(25-27)CTC>CTG	p.L9L	SERPINA7_uc010npd.2_Silent_p.L9L|SERPINA7_uc010npe.1_Silent_p.L9L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	9					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	CAAGTACCAAGAGAACCAGAT	0.448													0	0	0	0.001855	0	12	38										C	105281023	G	C	105281023	2	2	63	1	0	0	0	0	0	0	0	1	14094	929	33	1		1	SERPINA7	23	105281023	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	1781553	105281023	49989537	525	18920										
SLITRK4	139065	broad.mit.edu	37	chrX	142718202	142718202	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.535238095238095	281	2.58058678386248e-110	4.14136767522394	4.92514964872615	3.7722143907758	3.83989145109099e-08	4.99185888641829e-07	213	aagtcactgggagtttcacaGatagcttctcctatgtaaat	8	8	3	1			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:142718202G>T	uc004fbx.2	-	2	1099	c.723C>A	c.(721-723)ATC>ATA	p.I241I	SLITRK4_uc004fby.2_Silent_p.I241I	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	241	Extracellular (Potential).|LRRCT 1.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTTTCACAGATAGCTTCTC	0.433													1	0	1.12685e-05	0.004482	1.19034e-05	7	18										T	142718202	G	T	142718202	2	4	63	1	0	0	0	0	0	0	0	1	14745	932	33	3		3	SLITRK4	23	142718202	Silent	SNP	G	TCGA-DK-A3IU-01A-11D-A20D-08	37437179	142718202	12552358	526	18921										
TAS1R3	83756	broad.mit.edu	37	chr1	1268918	1268918	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gcaccttttgtggccaggatGagtggtccccggagcgaagc	15	11	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:1268918G>T	uc010nyk.1	+	6	1633	c.1633G>T	c.(1633-1635)GAG>TAG	p.E545*		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	545	Extracellular (Potential).|Required for brazzein responsiveness.				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGGCCAGGATGAGTGGTCCCC	0.637													1	0	1.88708e-17	0.008361	2.09522e-17	22	60										T	1268918	G	T	1268918	4	4	64	1	0	0	0	0	0	1	0	0	15561	1291	45	3	1655	3	TAS1R3	1	1268918	Nonsense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		1268918	247981703	1	18922										
CD164L2	388611	broad.mit.edu	37	chr1	27706644	27706644	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	acctccgataaagctggcccCgtcaaatccagggctgtggg	12	13	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:27706644C>T	uc001boc.2	-	5	491	c.415G>A	c.(415-417)GGG>AGG	p.G139R		NM_207397	NP_997280	Q6UWJ8	C16L2_HUMAN	CD164 sialomucin-like 2	139	Extracellular (Potential).					integral to membrane					0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCTGGCCCCGTCAAATCCA	0.617													0	0	0	0.00308	0	5	93										T	27706644	C	T	27706644	3	4	64	1	0	0	0	0	1	0	0	0	2970	652	23	2	110	2	CD164L2	1	27706644	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	26437726	27706644	221543977	2	18923										
FOXD2	2306	broad.mit.edu	37	chr1	47904409	47904409	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cccgggcaagggcaactactGgacgctggacccggagtcgg	16	13	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:47904409G>A	uc001crm.2	+	1	2721	c.602G>A	c.(601-603)TGG>TAG	p.W201*		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	201	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		GGCAACTACTGGACGCTGGAC	0.672													0	0	0	0.01441	0	53	131										A	47904409	G	A	47904409	4	1	64	1	0	0	0	0	0	1	0	0	5997	1357	47	2	604	2	FOXD2	1	47904409	Nonsense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	20197765	47904409	201346212	3	18924										
CRNN	49860	broad.mit.edu	37	chr1	152382699	152382700	+	Missense_Mutation	DNP	CA	CA	TG													0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tgtccctgcctgtatctgagCatgtcctcctgtcacagcct							TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:152382699_152382700CA>TG	uc001ezx.2	-	3	932_933	c.858_859TG>CA	c.(856-861)CATGCT>CACACT	p.A287T		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	287	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTATCTGAGCATGTCCTCCTG	0.614													0	0	0	0.004672	0	7	508										TG	152382700	CA	TG	152382699	3	4	64	1	0	0	0	0	1	0	0	0	3892	710	25	2	632	2	CRNN	1	152382699	Missense_Mutation	DNP	CA	TCGA-DK-A3IV-01A-22D-A21A-08	104478290	152382699	96867922	4	18925										
PYGO2	90780	broad.mit.edu	37	chr1	154933468	154933468	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ttcacctgagtatttgacttCcttcgcttcttttctggact	6	11	3	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:154933468C>A	uc001fft.2	-	2	344	c.138G>T	c.(136-138)AGG>AGT	p.R46S		NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	46	Nuclear localization signal (Potential).|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TATTTGACTTCCTTCGCTTCT	0.502													1	0	6.40141e-05	0.010729	6.80713e-05	8	436										A	154933468	C	A	154933468	3	1	64	1	0	0	0	0	1	0	0	0	12864	854	30	3	1090	3	PYGO2	1	154933468	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	2550769	154933468	94317153	5	18926										
PIGC	5279	broad.mit.edu	37	chr1	172410941	172410941	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ccatgaatgttttctttaaaAagctgcaagcgaatgaggta	9	6	1	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:172410941A>G	uc001gil.2	-	2	1103	c.822T>C	c.(820-822)CTT>CTC	p.L274L	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Silent_p.L274L|PIGC_uc001gio.2_Silent_p.L274L	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	274					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						TTTCTTTAAAAAGCTGCAAGC	0.438													0	0	0	0.006122	0	17	57										G	172410941	A	G	172410941	2	3	64	1	0	0	0	0	0	0	0	1	11886	1	1	5		5	PIGC	1	172410941	Silent	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08	17477473	172410941	76839680	6	18927										
ASPM	259266	broad.mit.edu	37	chr1	197059202	197059202	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cacaacaaagtggagacaatCtagtaactacctctgaaaga	7	9	2	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:197059202C>T	uc001gtu.2	-	25	10099	c.9842G>A	c.(9841-9843)AGA>AAA	p.R3281K	ASPM_uc001gtv.2_Missense_Mutation_p.R1696K|ASPM_uc001gtw.3_Missense_Mutation_p.R1129K	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3281					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGGAGACAATCTAGTAACTAC	0.333													0	0	0	0.006122	0	14	37										T	197059202	C	T	197059202	3	4	64	1	0	0	0	0	1	0	0	0	1056	913	32	1	607	1	ASPM	1	197059202	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	24648261	197059202	52191419	7	18928										
PPFIA4	8497	broad.mit.edu	37	chr1	203025554	203025554	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ataaagccaccataaaatgtGagacttctcctccttcctca	4	13	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:203025554G>A	uc001gyz.2	+	5	1233	c.640G>A	c.(640-642)GAG>AAG	p.E214K	PPFIA4_uc009xaj.2_Missense_Mutation_p.E845K|PPFIA4_uc010pqf.1_Missense_Mutation_p.E427K|PPFIA4_uc001gza.2_Missense_Mutation_p.E214K|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	214					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						CATAAAATGTGAGACTTCTCC	0.577													0	0	0	0.010729	0	9	51										A	203025554	G	A	203025554	3	1	64	1	0	0	0	0	1	0	0	0	12312	1291	45	1	658	1	PPFIA4	1	203025554	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	5966352	203025554	46225067	8	18929										
NFASC	23114	broad.mit.edu	37	chr1	204951129	204951129	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cctgagccagagtccgtcatCggttactccggagaagattg	12	11	1	4			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:204951129C>T	uc001hbj.2	+	21	2779	c.2451C>T	c.(2449-2451)ATC>ATT	p.I817I	NFASC_uc010pra.1_Silent_p.I813I|NFASC_uc001hbi.2_Silent_p.I813I|NFASC_uc010prb.1_Silent_p.I828I|NFASC_uc010prc.1_Silent_p.I384I|NFASC_uc001hbk.1_Silent_p.I623I|NFASC_uc001hbl.1_Silent_p.I67I	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	817	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGTCCGTCATCGGTTACTCCG	0.607													0	0	0	0.016723	0	9	19										T	204951129	C	T	204951129	2	4	64	1	0	0	0	0	0	0	0	1	10359	874	31	1		1	NFASC	1	204951129	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	1925575	204951129	44299492	9	18930										
LRRTM1	347730	broad.mit.edu	37	chr2	80530714	80530714	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tggccggcgcgcagctccgaGaggctgttgtagcgcaggga	18	11	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:80530714G>A	uc002sok.1	-	2	501	c.231C>T	c.(229-231)CTC>CTT	p.L77L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	77	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCAGCTCCGAGAGGCTGTTGT	0.647										HNSCC(69;0.2)			0	0	0	0.009096	0	4	63										A	80530714	G	A	80530714	2	1	64	1	0	0	0	0	0	0	0	1	9039	929	33	1		1	LRRTM1	2	80530714	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		80530714	162668659	10	18931										
NEB	4703	broad.mit.edu	37	chr2	152484126	152484126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gtgcaggtagttcttgtagtCcacatcgctgactaaggtct	11	9	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:152484126C>T	uc010fnx.2	-	65	9516	c.9325G>A	c.(9325-9327)GAC>AAC	p.D3109N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3109	Nebulin 84.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTGTAGTCCACATCGCTG	0.522													0	0	0	0.004482	0	8	250										T	152484126	C	T	152484126	3	4	64	1	0	0	0	0	1	0	0	0	10302	855	30	1	16088	1	NEB	2	152484126	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	71953412	152484126	90715247	11	18932										
TTN	7273	broad.mit.edu	37	chr2	179613777	179613777	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ttcacctttttccccgggtaGtgtatctcttcaccaaggga	8	12	3	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:179613777G>C	uc002unb.2	-	46	13574	c.13350C>G	c.(13348-13350)CAC>CAG	p.H4450Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCCGGGTAGTGTATCTCTT	0.333													0	0	0	0.014758	0	4	35										C	179613777	G	C	179613777	3	2	64	1	0	0	0	0	1	0	0	0	16732	1020	36	4	96947	4	TTN	2	179613777	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	27129651	179613777	63585596	12	18933										
NBEAL1	65065	broad.mit.edu	37	chr2	204058632	204058632	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aactcaagtcattttttataGaggtaatatcctacttggta	6	6	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:204058632G>C	uc002uzt.3	+	46	7282	c.6949G>C	c.(6949-6951)GAG>CAG	p.E2317Q	NBEAL1_uc002uzs.3_Intron	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2317							binding			ovary(1)|skin(1)	2						ATTTTTTATAGAGGTAATATC	0.308													0	0	0	0.014758	0	3	36										C	204058632	G	C	204058632	3	2	64	1	0	0	0	0	1	0	0	0	10188	943	33	1	7127	1	NBEAL1	2	204058632	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	24444855	204058632	39140741	13	18934										
SMARCAL1	50485	broad.mit.edu	37	chr2	217342939	217342939	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ccaacaggcccctgattcaaGagaagattaaagttctggca	9	10	2	3	rs119473033		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:217342939G>C	uc002vgc.3	+	17	2872	c.2542G>C	c.(2542-2544)GAG>CAG	p.E848Q	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.E848Q|SMARCAL1_uc010fvg.2_Missense_Mutation_p.E826Q	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	848	Helicase C-terminal.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCTGATTCAAGAGAAGATTAA	0.458									Schimke_Immuno-Osseous_Dysplasia				0	0	0	0.007835	0	33	51										C	217342939	G	C	217342939	3	2	64	1	0	0	0	0	1	0	0	0	14773	943	33	1	2600	1	SMARCAL1	2	217342939	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	13284307	217342939	25856434	14	18935										
DOCK10	55619	broad.mit.edu	37	chr2	225651829	225651829	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ttcagatatgaccgatgaatGtcgtagtagagatctgacaa	10	6	2	5			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:225651829G>A	uc010fwz.1	-	50	5804	c.5565C>T	c.(5563-5565)GAC>GAT	p.D1855D	DOCK10_uc002vob.2_Silent_p.D1849D|DOCK10_uc002voa.2_Silent_p.D511D|DOCK10_uc002voc.2_Silent_p.D676D	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1855	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ACCGATGAATGTCGTAGTAGA	0.403													0	0	0	0.001168	0	5	69										A	225651829	G	A	225651829	2	1	64	1	0	0	0	0	0	0	0	1	4685	1368	48	2		2	DOCK10	2	225651829	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	8308890	225651829	17547544	15	18936										
SLC16A14	151473	broad.mit.edu	37	chr2	230911105	230911105	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gcccaccatccttctcttctGttcttccctgctgtccagtt	5	17	3	0	rs111627569		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:230911105G>C	uc002vqd.1	-	4	1100	c.737C>G	c.(736-738)ACA>AGA	p.T246R	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.T246R|SLC16A14_uc002vqf.2_Missense_Mutation_p.T246R	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	246	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CTTCTCTTCTGTTCTTCCCTG	0.582													0	0	0	0.001984	0	5	106										C	230911105	G	C	230911105	3	2	64	1	0	0	0	0	1	0	0	0	14407	1377	48	4	803	4	SLC16A14	2	230911105	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	5259276	230911105	12288268	16	18937										
FANCD2	2177	broad.mit.edu	37	chr3	10107166	10107166	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	acggaaacttggaggagattGatggtctactaggtatggga	15	4	1	2	rs150217066		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:10107166G>A	uc003buw.2	+	24	2335	c.2257G>A	c.(2257-2259)GAT>AAT	p.D753N	FANCD2_uc003bux.1_Missense_Mutation_p.D753N|FANCD2_uc003buy.1_Missense_Mutation_p.D753N|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	753					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GGAGGAGATTGATGGTCTACT	0.448			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.013726	0	28	57										A	10107166	G	A	10107166	3	1	64	1	0	0	0	0	1	0	0	0	5665	1290	45	1	2347	1	FANCD2	3	10107166	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		10107166	187915264	17	18938										
NUP210	23225	broad.mit.edu	37	chr3	13367407	13367407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tgtggaggatgctgttggccGaggagctccaggttcctgag	17	8	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:13367407G>A	uc003bxv.1	-	33	4615	c.4532C>T	c.(4531-4533)TCA>TTA	p.S1511L		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1511	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GCTGTTGGCCGAGGAGCTCCA	0.622													0	0	0	0.010504	0	14	76										A	13367407	G	A	13367407	3	1	64	1	0	0	0	0	1	0	0	0	10760	1059	37	1	1163	1	NUP210	3	13367407	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	3260241	13367407	184655023	18	18939										
STAB1	23166	broad.mit.edu	37	chr3	52552854	52552854	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ggggtacgccacggccctctCagggcacccactgcgcttca	12	17	2	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:52552854C>G	uc003dej.2	+	48	5077	c.5003C>G	c.(5002-5004)TCA>TGA	p.S1668*	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1668	Extracellular (Potential).|FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACGGCCCTCTCAGGGCACCCA	0.547													0	0	0	0.009096	0	4	27										G	52552854	C	G	52552854	4	3	64	1	0	0	0	0	0	1	0	0	15236	838	29	1	5193	1	STAB1	3	52552854	Nonsense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	39185447	52552854	145469576	19	18940										
DCBLD2	131566	broad.mit.edu	37	chr3	98531284	98531284	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aataattggtggcaaaaagtTattacgcacatcctggtgat	9	6	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:98531284T>C	uc003dtd.2	-	10	1618	c.1255A>G	c.(1255-1257)AAC>GAC	p.N419D	DCBLD2_uc003dte.2_Missense_Mutation_p.N419D	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	419	Extracellular (Potential).|F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GGCAAAAAGTTATTACGCACA	0.348													0	0	0	0.010729	0	12	31										C	98531284	T	C	98531284	3	2	64	1	0	0	0	0	1	0	0	0	4281	1754	61	5	1100	5	DCBLD2	3	98531284	Missense_Mutation	SNP	T	TCGA-DK-A3IV-01A-22D-A21A-08	45978430	98531284	99491146	20	18941										
TFG	10342	broad.mit.edu	37	chr3	100463681	100463681	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gtgtgtgtgttttcaggtcaGatgtaccaacagtaccagca	11	8	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:100463681G>C	uc003due.2	+	7	1175	c.726G>C	c.(724-726)CAG>CAC	p.Q242H	TFG_uc003duf.2_Missense_Mutation_p.Q242H|TFG_uc003dug.2_Missense_Mutation_p.Q238H|TFG_uc003duh.2_Missense_Mutation_p.Q238H|TFG_uc003dui.2_Missense_Mutation_p.Q242H	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	242					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						TTTCAGGTCAGATGTACCAAC	0.458			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	0.01441	0	45	102										C	100463681	G	C	100463681	3	2	64	1	0	0	0	0	1	0	0	0	15803	933	33	1	748	1	TFG	3	100463681	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	1932397	100463681	97558749	21	18942										
GRAMD1C	54762	broad.mit.edu	37	chr3	113619898	113619898	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	agcctgactagacaggaattCtggcaactgctccagcagaa	10	11	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:113619898C>G	uc003eaq.3	+	7	637	c.561C>G	c.(559-561)TTC>TTG	p.F187L	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.F20L|GRAMD1C_uc003eas.2_5'UTR	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	187						integral to membrane				ovary(2)|skin(1)	3						GACAGGAATTCTGGCAACTGC	0.373													0	0	0	0.01892	0	20	48										G	113619898	C	G	113619898	3	3	64	1	0	0	0	0	1	0	0	0	6749	912	32	1	587	1	GRAMD1C	3	113619898	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	13156217	113619898	84402532	22	18943										
RBP1	5947	broad.mit.edu	37	chr3	139236517	139236517	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cagaccacaccttccactctCatctcctgaaacaaaagcag	4	16	2	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:139236517C>T	uc003eti.2	-	4	657	c.546G>A	c.(544-546)ATG>ATA	p.M182I		NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	120						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CTTCCACTCTCATCTCCTGAA	0.488													0	0	0	0.00623	0	34	92										T	139236517	C	T	139236517	3	4	64	1	0	0	0	0	1	0	0	0	13155	826	29	1	51	1	RBP1	3	139236517	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	25616619	139236517	58785913	23	18944										
UGT2B28	54490	broad.mit.edu	37	chr4	70160324	70160324	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ccctgcatcgagcagtcttcTggattgaatttgtgatgtgc	11	9	2	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:70160324T>A	uc003hej.2	+	6	1389	c.1387T>A	c.(1387-1389)TGG>AGG	p.W463R	UGT2B28_uc010ihr.2_3'UTR	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	463					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AGCAGTCTTCTGGATTGAATT	0.413													0	0	0	0.00874	0	33	79										A	70160324	T	A	70160324	3	1	64	1	0	0	0	0	1	0	0	0	16957	1580	55	5	1409	5	UGT2B28	4	70160324	Missense_Mutation	SNP	T	TCGA-DK-A3IV-01A-22D-A21A-08		70160324	120993952	24	18945										
CCRN4L	25819	broad.mit.edu	37	chr4	139966392	139966392	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cctacaagctgctgagtgctGatgggcagtcagaaccccca	11	13	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:139966392G>C	uc003ihl.2	+	3	1253	c.1060G>C	c.(1060-1062)GAT>CAT	p.D354H		NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	354					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					GCTGAGTGCTGATGGGCAGTC	0.517													0	0	0	0.00499	0	15	47										C	139966392	G	C	139966392	3	2	64	1	0	0	0	0	1	0	0	0	2951	1290	45	1	1070	1	CCRN4L	4	139966392	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	69806068	139966392	51187884	25	18946										
HAND2	9464	broad.mit.edu	37	chr4	174450071	174450071	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gggtacgttggggatgcactCgcgcagttcggcgaaggcgc	18	10	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:174450071C>G	uc003ith.1	-	1	1308	c.370G>C	c.(370-372)GAG>CAG	p.E124Q	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Missense_Mutation_p.R89P|HAND2_uc010ire.1_Missense_Mutation_p.E124Q	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	124	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		GGGATGCACTCGCGCAGTTCG	0.557													0	0	0	0.01441	0	44	131										G	174450071	C	G	174450071	3	3	64	1	0	0	0	0	1	0	0	0	6950	893	31	1	291	1	HAND2	4	174450071	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	34483679	174450071	16704205	26	18947										
CCDC110	256309	broad.mit.edu	37	chr4	186379933	186379933	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ggctttcttttagttcatttCcaagtgagcttttttctttt	6	7	3	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:186379933C>T	uc003ixu.3	-	6	1884	c.1808G>A	c.(1807-1809)GGA>GAA	p.G603E	CCDC110_uc003ixv.3_Missense_Mutation_p.G566E|CCDC110_uc011ckt.1_Missense_Mutation_p.G603E	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	603	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TAGTTCATTTCCAAGTGAGCT	0.323													0	0	0	0.016723	0	11	21										T	186379933	C	T	186379933	3	4	64	1	0	0	0	0	1	0	0	0	2747	855	30	1	701	1	CCDC110	4	186379933	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	11929862	186379933	4774343	27	18948										
CDH10	1008	broad.mit.edu	37	chr5	24491853	24491853	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ctgaattgggtaatcattgtCtgatatcaccacaggcaaga	9	8	3	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:24491853C>G	uc003jgr.1	-	11	2040	c.1708G>C	c.(1708-1710)GAC>CAC	p.D570H	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	570	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAATCATTGTCTGATATCACC	0.413										HNSCC(23;0.051)			0	0	0	0.004672	0	3	45										G	24491853	C	G	24491853	3	3	64	1	0	0	0	0	1	0	0	0	3096	913	32	1	666	1	CDH10	5	24491853	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08		24491853	156423407	28	18949										
PDZD2	23037	broad.mit.edu	37	chr5	32074304	32074304	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	actggtgagcaaggccatctCggcacctcttcttggtagct	11	12	3	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:32074304C>T	uc003jhl.2	+	18	3480	c.3092C>T	c.(3091-3093)TCG>TTG	p.S1031L	PDZD2_uc003jhm.2_Missense_Mutation_p.S1031L|PDZD2_uc011cnx.1_Missense_Mutation_p.S857L	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1031					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AAGGCCATCTCGGCACCTCTT	0.567													0	0	0	0.01441	0	54	28										T	32074304	C	T	32074304	3	4	64	1	0	0	0	0	1	0	0	0	11701	893	31	1	3158	1	PDZD2	5	32074304	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	7582451	32074304	148840956	29	18950										
DHX29	54505	broad.mit.edu	37	chr5	54586091	54586091	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ctgagcctctttttggccttGcttgtttttttctagtttaa	7	8	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:54586091G>C	uc003jpx.2	-	7	982	c.862C>G	c.(862-864)CAA>GAA	p.Q288E	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	288	Potential.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTTTGGCCTTGCTTGTTTTTT	0.328													0	0	0	0.004672	0	3	8										C	54586091	G	C	54586091	3	2	64	1	0	0	0	0	1	0	0	0	4503	1328	46	4	3331	4	DHX29	5	54586091	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	22511787	54586091	126329169	30	18951										
DEPDC1B	55789	broad.mit.edu	37	chr5	59893730	59893730	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tcttgatagacttcaggataGgatttctgaaactaaaaaaa	7	5	3	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:59893730G>A	uc003jsh.2	-	11	1513	c.1440C>T	c.(1438-1440)TCC>TCT	p.S480S	DEPDC1B_uc011cqm.1_Silent_p.S418S|DEPDC1B_uc011cqn.1_Silent_p.S391S	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				CTTCAGGATAGGATTTCTGAA	0.383													0	0	0	0.009096	0	4	11										A	59893730	G	A	59893730	2	1	64	1	0	0	0	0	0	0	0	1	4440	987	35	2		2	DEPDC1B	5	59893730	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	5307639	59893730	121021530	31	18952										
GCNT4	51301	broad.mit.edu	37	chr5	74324587	74324587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ctgctgttcttcaagcttttCtgccaagcatttaatcaaga	6	10	4	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:74324587C>G	uc003kdn.2	-	1	2138	c.1276G>C	c.(1276-1278)GAA>CAA	p.E426Q		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	426	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TCAAGCTTTTCTGCCAAGCAT	0.373													0	0	0	0.003163	0	13	25										G	74324587	C	G	74324587	3	3	64	1	0	0	0	0	1	0	0	0	6303	922	32	1	89	1	GCNT4	5	74324587	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	14430857	74324587	106590673	32	18953										
KCTD16	57528	broad.mit.edu	37	chr5	143587001	143587001	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gggcttttgatatgttgtcaGagtgtggattccacatggtg	14	5	1	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:143587001G>A	uc003lnm.1	+	3	1353	c.724G>A	c.(724-726)GAG>AAG	p.E242K	KCTD16_uc003lnn.1_Missense_Mutation_p.E242K	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	242						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TATGTTGTCAGAGTGTGGATT	0.428													0	0	0	0.012213	0	26	66										A	143587001	G	A	143587001	3	1	64	1	0	0	0	0	1	0	0	0	8103	943	33	1	726	1	KCTD16	5	143587001	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	69262414	143587001	37328259	33	18954										
SCGN	10590	broad.mit.edu	37	chr6	25665182	25665182	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ttccttcagcttgctggtatGttcttatctgaggatgaaaa	9	7	3	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:25665182G>A	uc003nfb.2	+	4	461	c.258G>A	c.(256-258)ATG>ATA	p.M86I	SCGN_uc010jpz.2_5'UTR	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	86	EF-hand 2.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						TTGCTGGTATGTTCTTATCTG	0.478													0	0	0	0.010504	0	15	38										A	25665182	G	A	25665182	3	1	64	1	0	0	0	0	1	0	0	0	13903	1377	48	2	272	2	SCGN	6	25665182	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		25665182	145449885	34	18955										
HIST1H2BO	8348	broad.mit.edu	37	chr6	27861555	27861555	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gtgcgcctgctgctgcccggGgagctggccaagcacgccgt	16	15	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:27861555G>A	uc003nkc.1	+	1	353	c.315G>A	c.(313-315)GGG>GGA	p.G105G	HIST1H3J_uc003nka.2_5'Flank|HIST1H2AM_uc003nkb.1_5'Flank	NM_003527	NP_003518	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	105					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TGCTGCCCGGGGAGCTGGCCA	0.642													0	0	0	0.001984	0	4	114										A	27861555	G	A	27861555	2	1	64	1	0	0	0	0	0	0	0	1	7154	1219	43	2		2	HIST1H2BO	6	27861555	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	2196373	27861555	143253512	35	18956										
IER3	8870	broad.mit.edu	37	chr6	30712140	30712140	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cggtgcccgcgagaggcgctGgggcgcccggcaggggccgc	21	15	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:30712140G>A	uc003nrn.2	-	1	188	c.156C>T	c.(154-156)CCC>CCT	p.P52P	FLOT1_uc003nrm.2_5'Flank|FLOT1_uc011dmr.1_5'Flank	NM_003897	NP_003888	P46695	IEX1_HUMAN	immediate early response 3	52	Cytoplasmic (Potential).				anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding				0						GAGAGGCGCTGGGGCGCCCGG	0.731													0	0	0	0.004672	0	3	7										A	30712140	G	A	30712140	2	1	64	1	0	0	0	0	0	0	0	1	7506	1335	47	2		2	IER3	6	30712140	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	2850585	30712140	140402927	36	18957										
PBX2	5089	broad.mit.edu	37	chr6	32155525	32155525	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gaaatactcatttaggacctCagtggcctgtttgctgaagt	10	8	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:32155525C>T	uc003oav.1	-	5	1040	c.769G>A	c.(769-771)GAG>AAG	p.E257K	PBX2_uc003oaw.2_Missense_Mutation_p.E257K	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	257	Homeobox; TALE-type.						transcription factor binding			ovary(1)	1						TTTAGGACCTCAGTGGCCTGT	0.527													0	0	0	0.00308	0	7	19										T	32155525	C	T	32155525	3	4	64	1	0	0	0	0	1	0	0	0	11493	835	29	1	543	1	PBX2	6	32155525	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	1443385	32155525	138959542	37	18958										
TFAP2B	7021	broad.mit.edu	37	chr6	50791308	50791308	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gacccctactcccacgtcaaCgacccctactccctgaaccc	4	22	1	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:50791308C>T	uc003pag.2	+	2	436	c.270C>T	c.(268-270)AAC>AAT	p.N90N		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	90	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					CCCACGTCAACGACCCCTACT	0.672													0	0	0	0.012213	0	26	59										T	50791308	C	T	50791308	2	4	64	1	0	0	0	0	0	0	0	1	15785	535	19	2		2	TFAP2B	6	50791308	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	18635783	50791308	120323759	38	18959										
HMGCLL1	54511	broad.mit.edu	37	chr6	55360317	55360317	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ctttcatcacactttccaacAttcttttcatacttcctgga	2	13	4	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:55360317A>T	uc003pcn.2	-	8	944	c.785T>A	c.(784-786)ATG>AAG	p.M262K	HMGCLL1_uc003pco.2_Missense_Mutation_p.M232K|HMGCLL1_uc010jzx.2_Missense_Mutation_p.M133K|HMGCLL1_uc011dxc.1_Missense_Mutation_p.M200K|HMGCLL1_uc011dxd.1_Missense_Mutation_p.M129K|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	262							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACTTTCCAACATTCTTTTCAT	0.443													0	0	0	0.007413	0	17	44										T	55360317	A	T	55360317	3	4	64	1	0	0	0	0	1	0	0	0	7230	217	8	5	339	5	HMGCLL1	6	55360317	Missense_Mutation	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08	4569009	55360317	115754750	39	18960										
GABRR2	2570	broad.mit.edu	37	chr6	90024839	90024839	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ttttctgctctccacgagaaCcatcaagcaaaacaagaaca	5	12	3	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:90024839C>A	uc003pnb.2	-	1	129	c.121G>T	c.(121-123)GTT>TTT	p.V41F		NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	41					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TCCACGAGAACCATCAAGCAA	0.473													1	0	9.53978e-28	0.01441	1.07501e-27	54	143										A	90024839	C	A	90024839	3	1	64	1	0	0	0	0	1	0	0	0	6177	507	18	4	1387	4	GABRR2	6	90024839	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	34664522	90024839	81090228	40	18961										
MCHR2	84539	broad.mit.edu	37	chr6	100395738	100395738	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aggccccccaaacacccactCtccccctcgggcccattggt	7	21	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:100395738C>G	uc003pqh.1	-	3	607	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	MCHR2_uc003pqi.1_Missense_Mutation_p.E98Q	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	98	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AACACCCACTCTCCCCCTCGG	0.493													0	0	0	0.009096	0	4	130										G	100395738	C	G	100395738	3	3	64	1	0	0	0	0	1	0	0	0	9383	922	32	1	746	1	MCHR2	6	100395738	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	10370899	100395738	70719329	41	18962										
TSPYL1	7259	broad.mit.edu	37	chr6	116600209	116600209	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tcctccgctccaggtagtgtCgacgcatccgcccaaacttg	9	16	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:116600209C>G	uc003pwp.3	-	1	1072	c.785G>C	c.(784-786)CGA>CCA	p.R262P	DSE_uc011ebf.1_Intron|DSE_uc003pwq.1_5'Flank|DSE_uc003pwr.2_5'Flank|DSE_uc003pws.2_5'Flank	NM_003309	NP_003300	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	262					nucleosome assembly	nucleolus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CAGGTAGTGTCGACGCATCCG	0.567													0	0	0	0.015359	0	29	110										G	116600209	C	G	116600209	3	3	64	1	0	0	0	0	1	0	0	0	16656	884	31	1	532	1	TSPYL1	6	116600209	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	16204471	116600209	54514858	42	18963										
AKAP7	9465	broad.mit.edu	37	chr6	131490373	131490373	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	caggttggatttgtgaagctGgcagaaggagatcatgtaaa	14	4	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:131490373G>A	uc003qck.2	+	5	582	c.549G>A	c.(547-549)CTG>CTA	p.L183L	AKAP7_uc011ebz.1_Silent_p.L161L|AKAP7_uc003qcl.1_Silent_p.L64L	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		TTGTGAAGCTGGCAGAAGGAG	0.378													0	0	0	0.007835	0	34	102										A	131490373	G	A	131490373	2	1	64	1	0	0	0	0	0	0	0	1	456	1335	47	2		2	AKAP7	6	131490373	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	14890164	131490373	39624694	43	18964										
TCP10L2	401285	broad.mit.edu	37	chr6	167590518	167590518	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cttttggaaaaatttcacctCtgtcagctgatgaagagaca	8	8	3	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:167590518C>T	uc010kkp.2	+	4	525	c.394C>T	c.(394-396)CTG>TTG	p.L132L		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	132											0						AATTTCACCTCTGTCAGCTGA	0.418													0	0	0	0.008871	0	12	43										T	167590518	C	T	167590518	2	4	64	1	0	0	0	0	0	0	0	1	15709	912	32	1		1	TCP10L2	6	167590518	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	36100145	167590518	3524549	44	18965										
DNAH11	8701	broad.mit.edu	37	chr7	21695538	21695538	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ttctgcacacagggcagttgGaatgtacagcaaagaaaagg	12	7	1	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:21695538G>C	uc003svc.2	+	29	5079	c.5048G>C	c.(5047-5049)GGA>GCA	p.G1683A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1683	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGGGCAGTTGGAATGTACAGC	0.428									Kartagener_syndrome				0	0	0	0.009096	0	4	35										C	21695538	G	C	21695538	3	2	64	1	0	0	0	0	1	0	0	0	4599	1174	41	1	5162	1	DNAH11	7	21695538	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		21695538	137443125	45	18966										
PKD1L1	168507	broad.mit.edu	37	chr7	47832313	47832313	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tggatgttttttccagaaggGggagttgtaggctgtcggac	16	5	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:47832313G>C	uc003tny.1	-	56	8438	c.8438C>G	c.(8437-8439)CCC>CGC	p.P2813R	C7orf69_uc003tnz.3_5'Flank|C7orf69_uc003toa.1_5'Flank	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2813	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TTCCAGAAGGGGGAGTTGTAG	0.428													0	0	0	0.008361	0	27	64										C	47832313	G	C	47832313	3	2	64	1	0	0	0	0	1	0	0	0	11964	1232	43	4	119	4	PKD1L1	7	47832313	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	26136775	47832313	111306350	46	18967										
CROT	54677	broad.mit.edu	37	chr7	87011302	87011302	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aatttttcagaatgaaggaaGatggaaggtatgtttgaata	11	1	1	4			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:87011302G>C	uc003uit.2	+	11	1300	c.1055G>C	c.(1054-1056)AGA>ACA	p.R352T	CROT_uc003uiu.2_Missense_Mutation_p.R380T	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	352					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	AATGAAGGAAGATGGAAGGTA	0.303													0	0	0	0.009096	0	4	31										C	87011302	G	C	87011302	3	2	64	1	0	0	0	0	1	0	0	0	3894	942	33	1	1177	1	CROT	7	87011302	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	39178989	87011302	72127361	47	18968										
CASD1	64921	broad.mit.edu	37	chr7	94164632	94164632	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cacgtgcagatcctgtttatGaagatctattaagtgaaaat	8	6	1	4			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:94164632G>A	uc003uni.3	+	8	867	c.640G>A	c.(640-642)GAA>AAA	p.E214K	CASD1_uc003unh.2_Intron|CASD1_uc003unj.3_Missense_Mutation_p.E214K	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	214						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TCCTGTTTATGAAGATCTATT	0.328													0	0	0	0.004007	0	14	42										A	94164632	G	A	94164632	3	1	64	1	0	0	0	0	1	0	0	0	2664	1291	45	1	670	1	CASD1	7	94164632	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	7153330	94164632	64974031	48	18969										
TAF6	6878	broad.mit.edu	37	chr7	99709745	99709745	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cctcaccgccctcttggcctCgcaggagcccacgcaggcct	10	20	2	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:99709745C>T	uc003uti.2	-	7	787	c.706G>A	c.(706-708)GAG>AAG	p.E236K	TAF6_uc003utg.2_Missense_Mutation_p.E158K|TAF6_uc003uth.2_Missense_Mutation_p.E293K|TAF6_uc003utk.2_Missense_Mutation_p.E236K|TAF6_uc011kji.1_Missense_Mutation_p.E273K|TAF6_uc003utj.2_Missense_Mutation_p.E226K|TAF6_uc003utl.2_Missense_Mutation_p.E236K|TAF6_uc003utm.2_Missense_Mutation_p.E236K|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	236					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCTTGGCCTCGCAGGAGCCC	0.672													0	0	0	0.00308	0	7	12										T	99709745	C	T	99709745	3	4	64	1	0	0	0	0	1	0	0	0	15527	893	31	1	1363	1	TAF6	7	99709745	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	5545113	99709745	59428918	49	18970										
ZNF282	8427	broad.mit.edu	37	chr7	148895819	148895819	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ctgggtcctgcggctgccccCgggcagcaagggggaggccc	18	15	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:148895819C>T	uc003wfm.2	+	2	665	c.560C>T	c.(559-561)CCG>CTG	p.P187L	ZNF282_uc011kun.1_Missense_Mutation_p.P187L|ZNF282_uc003wfn.2_Missense_Mutation_p.P127L|ZNF282_uc003wfo.2_Missense_Mutation_p.P127L	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	187					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGGCTGCCCCCGGGCAGCAAG	0.597													0	0	0	0.016723	0	10	64										T	148895819	C	T	148895819	3	4	64	1	0	0	0	0	1	0	0	0	17816	652	23	2	566	2	ZNF282	7	148895819	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	49186074	148895819	10242844	50	18971										
DOCK5	80005	broad.mit.edu	37	chr8	25174557	25174557	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gacatttatgtcaccctgatCcacggtgagtttgacaaagg	10	9	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr8:25174557C>G	uc003xeg.2	+	14	1490	c.1353C>G	c.(1351-1353)ATC>ATG	p.I451M	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.I165M|DOCK5_uc003xei.2_Missense_Mutation_p.I21M	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	451	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TCACCCTGATCCACGGTGAGT	0.478													0	0	0	0.004672	0	3	53										G	25174557	C	G	25174557	3	3	64	1	0	0	0	0	1	0	0	0	4690	845	30	1	1407	1	DOCK5	8	25174557	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08		25174557	121189465	51	18972										
CER1	9350	broad.mit.edu	37	chr9	14720234	14720234	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aagttcagtgcagttcagtgGcaagtgcatcgtggtgaact	13	7	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:14720234G>A	uc003zlj.2	-	2	703	c.658C>T	c.(658-660)CCA>TCA	p.P220S		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	220	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		CAGTTCAGTGGCAAGTGCATC	0.542													0	0	0	0.00308	0	5	134										A	14720234	G	A	14720234	3	1	64	1	0	0	0	0	1	0	0	0	3265	1203	42	2	149	2	CER1	9	14720234	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		14720234	126493197	52	18973										
C9orf64	84267	broad.mit.edu	37	chr9	86571110	86571110	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gctctgttgacggcggcgcaCagggaccagtacccactgta	13	13	1	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:86571110C>A	uc004anb.2	-	1	554	c.306G>T	c.(304-306)CTG>CTT	p.L102L	C9orf64_uc004anc.2_5'UTR	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	102											0						CGGCGGCGCACAGGGACCAGT	0.552													1	0	3.66854e-30	0.007835	4.19659e-30	30	137										A	86571110	C	A	86571110	2	1	64	1	0	0	0	0	0	0	0	1	2489	465	17	4		4	C9orf64	9	86571110	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	71850876	86571110	54642321	53	18974										
IKBKAP	8518	broad.mit.edu	37	chr9	111663910	111663910	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	caaaccaagccttgatacctCaatgtcattgatgaaaaagc	6	10	2	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:111663910C>T	uc004bdm.3	-	17	2426	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	IKBKAP_uc004bdl.2_Missense_Mutation_p.E287K|IKBKAP_uc011lwc.1_Missense_Mutation_p.E522K|IKBKAP_uc010mtq.2_Missense_Mutation_p.E287K	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	636					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CTTGATACCTCAATGTCATTG	0.433													0	0	0	0.007413	0	16	51										T	111663910	C	T	111663910	3	4	64	1	0	0	0	0	1	0	0	0	7610	835	29	1	2176	1	IKBKAP	9	111663910	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	25092800	111663910	29549521	54	18975										
ZNF248	57209	broad.mit.edu	37	chr10	38121105	38121105	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tctgatgttgagtgaggtttGacttctcccagaaggttttc	11	7	2	5			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:38121105G>C	uc001izd.1	-	6	1677	c.1178C>G	c.(1177-1179)TCA>TGA	p.S393*	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Nonsense_Mutation_p.S393*	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	393	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGAGGTTTGACTTCTCCCA	0.453													0	0	0	0.016522	0	23	70										C	38121105	G	C	38121105	4	2	64	1	0	0	0	0	0	1	0	0	17790	1294	45	1	565	1	ZNF248	10	38121105	Nonsense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		38121105	97413642	55	18976										
EGR2	1959	broad.mit.edu	37	chr10	64575663	64575663	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gtcaaaggggcctcccagttCggcattgggaaagatggtca	14	9	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:64575663C>G	uc010qim.1	-	2	281	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	EGR2_uc010qin.1_5'UTR|EGR2_uc001jmi.2_Missense_Mutation_p.E43Q|EGR2_uc010qio.1_Missense_Mutation_p.E56Q|EGR2_uc009xph.2_Missense_Mutation_p.E43Q	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	43					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CCTCCCAGTTCGGCATTGGGA	0.622													0	0	0	0.009096	0	4	140										G	64575663	C	G	64575663	3	3	64	1	0	0	0	0	1	0	0	0	4972	893	31	1	1311	1	EGR2	10	64575663	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	26454558	64575663	70959084	56	18977										
PANK1	53354	broad.mit.edu	37	chr10	91353589	91353589	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ccttgatgctacagcagatcCttgaaggccaaatcgttcat	8	11	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:91353589C>T	uc001kgp.1	-	4	1624	c.1468G>A	c.(1468-1470)GGA>AGA	p.G490R	PANK1_uc001kgn.1_Missense_Mutation_p.G265R|PANK1_uc001kgo.1_Intron|PANK1_uc009xtu.1_Missense_Mutation_p.G292R|uc001kgq.1_5'Flank|MIR107_hsa-mir-107|MI0000114_5'Flank	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	490					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	ACAGCAGATCCTTGAAGGCCA	0.448													0	0	0	0.008291	0	7	155										T	91353589	C	T	91353589	3	4	64	1	0	0	0	0	1	0	0	0	11416	690	24	2	344	2	PANK1	10	91353589	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	26777926	91353589	44181158	57	18978										
C10orf79	80217	broad.mit.edu	37	chr10	105948076	105948076	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	catctccaacctgcttctccCtgcttctggaagcgaggaaa	8	14	3	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:105948076C>T	uc001kxw.2	-	13	1755	c.1639G>A	c.(1639-1641)GGG>AGG	p.G547R	C10orf79_uc009xxq.2_5'Flank|C10orf79_uc001kxx.3_Missense_Mutation_p.G548R	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	547											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		CTGCTTCTCCCTGCTTCTGGA	0.463													0	0	0	0.004672	0	3	46										T	105948076	C	T	105948076	3	4	64	1	0	0	0	0	1	0	0	0	1618	681	24	2	3462	2	C10orf79	10	105948076	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	14594487	105948076	29586671	58	18979										
ACADSB	36	broad.mit.edu	37	chr10	124793889	124793889	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cagctaagaagaaatttcctGacttgtttgtcttcttggaa	8	7	2	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:124793889G>T	uc001lhb.2	+	2	177	c.60G>T	c.(58-60)CTG>CTT	p.L20L	ACADSB_uc010qub.1_5'UTR	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	20					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	GAAATTTCCTGACTTGTTTGT	0.353													1	0	1.37522e-17	0.007413	1.53821e-17	15	22										T	124793889	G	T	124793889	2	4	64	1	0	0	0	0	0	0	0	1	115	1277	45	3		3	ACADSB	10	124793889	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	18845813	124793889	10740858	59	18980										
EFCAB4A	283229	broad.mit.edu	37	chr11	831640	831642	+	In_Frame_Del	DEL	CTG	CTG	-													0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gcccgcctgcctgggcccacCtgctgctgctgctgttgctg							TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:831640_831642delCTG	uc001lrv.2	+	9	1509_1511	c.1131_1133delCTG	c.(1129-1134)ACCTGC>ACC	p.C383del	EFCAB4A_uc009ycm.1_3'UTR|EFCAB4A_uc001lrw.2_In_Frame_Del_p.C448del|CD151_uc001lrx.2_5'Flank|CD151_uc001lry.2_5'Flank|CD151_uc001lrz.2_5'Flank|CD151_uc001lsa.2_5'Flank|CD151_uc001lsb.2_5'Flank			Q8N4Y2	EFC4A_HUMAN	RecName: Full=EF-hand calcium-binding domain-containing protein 4A;	383	Cys-rich.				store-operated calcium entry		calcium ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTGGGCCCACCTGCTGCTGCTGC	0.695																		3	5	---	---								-	831642	CTG	-	831640	7	5	64	1	0	1	0	1	0	0	0	0	4936	696	24	0		0	EFCAB4A	11	831640	In_Frame_Del	DEL	CTG	TCGA-DK-A3IV-01A-22D-A21A-08		831640	134174876	60	18981										
KLC2	64837	broad.mit.edu	37	chr11	66033397	66033397	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gtggcaggcggggagaccgcCgcagcagccgagacatggct	18	12	0	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:66033397C>T	uc010rov.1	+	13	1759	c.1516C>T	c.(1516-1518)CGC>TGC	p.R506C	KLC2_uc010row.1_Missense_Mutation_p.R506C|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Missense_Mutation_p.R506C|KLC2_uc010rox.1_Missense_Mutation_p.R429C|KLC2_uc001ohc.2_Missense_Mutation_p.R506C|KLC2_uc001ohd.2_Missense_Mutation_p.R429C|KLC2_uc001ohe.1_Missense_Mutation_p.R367C|RAB1B_uc001ohf.2_5'Flank	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	506					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						GGGAGACCGCCGCAGCAGCCG	0.667													0	0	0	0.001168	0	4	67										T	66033397	C	T	66033397	3	4	64	1	0	0	0	0	1	0	0	0	8334	652	23	2	1562	2	KLC2	11	66033397	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	65201757	66033397	68973119	61	18982										
ODZ4	26011	broad.mit.edu	37	chr11	78419499	78419499	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gagatgatcccattctgatcGatgcgtctgatcatggtgcc	11	10	3	4			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:78419499G>C	uc001ozl.3	-	27	4579	c.4116C>G	c.(4114-4116)ATC>ATG	p.I1372M		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1372	Extracellular (Potential).|NHL 3.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CATTCTGATCGATGCGTCTGA	0.507													0	0	0	0.00623	0	37	20										C	78419499	G	C	78419499	3	2	64	1	0	0	0	0	1	0	0	0	10837	1048	37	1	4225	1	ODZ4	11	78419499	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	12386102	78419499	56587017	62	18983										
SYTL2	54843	broad.mit.edu	37	chr11	85420380	85420380	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	taaaatgtacttacgggtctGaacgctgtttttttacatcc	7	8	1	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:85420380G>C	uc010rth.1	-	12	2270	c.1994C>G	c.(1993-1995)TCA>TGA	p.S665*	SYTL2_uc010rtg.1_Nonsense_Mutation_p.S666*|SYTL2_uc010rti.1_Nonsense_Mutation_p.S641*|SYTL2_uc010rtj.1_Nonsense_Mutation_p.S633*|SYTL2_uc001pav.2_Nonsense_Mutation_p.S107*|SYTL2_uc010rte.1_Nonsense_Mutation_p.S67*|SYTL2_uc001pax.2_Nonsense_Mutation_p.S107*|SYTL2_uc001paz.2_5'UTR|SYTL2_uc001pba.2_Nonsense_Mutation_p.S50*|SYTL2_uc001pay.2_Nonsense_Mutation_p.S96*|SYTL2_uc001paw.2_Nonsense_Mutation_p.S67*|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Nonsense_Mutation_p.S963*|SYTL2_uc001pbb.2_Nonsense_Mutation_p.S1003*|SYTL2_uc001pbc.2_Nonsense_Mutation_p.S987*|SYTL2_uc010rtf.1_Nonsense_Mutation_p.S483*	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	665	C2 1.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TTACGGGTCTGAACGCTGTTT	0.413													0	0	0	0.01441	0	40	49										C	85420380	G	C	85420380	4	2	64	1	0	0	0	0	0	1	0	0	15480	1294	45	1	838	1	SYTL2	11	85420380	Nonsense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	7000881	85420380	49586136	63	18984										
PRB2	653247	broad.mit.edu	37	chr12	11546868	11546868	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cctggaggagatgggggaccTtgaggtttgttgcctccttg	16	8	0	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:11546868T>C	uc010shk.1	-	3	179	c.144A>G	c.(142-144)CAA>CAG	p.Q48Q		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ATGGGGGACCTTGAGGTTTGT	0.547													0	0	0	0.00308	0	5	217										C	11546868	T	C	11546868	2	2	64	1	0	0	0	0	0	0	0	1	12443	1606	56	5		5	PRB2	12	11546868	Silent	SNP	T	TCGA-DK-A3IV-01A-22D-A21A-08		11546868	122305027	64	18985										
KRT73	319101	broad.mit.edu	37	chr12	53007514	53007514	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gcctcggccttgctcttccgGgcgatctcctcatactgggc	11	16	3	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:53007514G>A	uc001sas.2	-	5	977	c.942C>T	c.(940-942)GCC>GCT	p.A314A		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	314	Rod.|Coil 2.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCTCTTCCGGGCGATCTCCT	0.587													0	0	0	0.012319	0	19	71										A	53007514	G	A	53007514	2	1	64	1	0	0	0	0	0	0	0	1	8486	1219	43	2		2	KRT73	12	53007514	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	41460646	53007514	80844381	65	18986										
HOXC4	3221	broad.mit.edu	37	chr12	54448079	54448079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gccagccagcccccgaccatCcctccagcgccgccagcaag	9	22	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:54448079C>T	uc001seu.2	+	3	1053	c.373C>T	c.(373-375)CCC>TCC	p.P125S	HOXC4_uc001sex.2_Missense_Mutation_p.P125S	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCCCGACCATCCCTCCAGCGC	0.582													0	0	0	0.00308	0	6	27										T	54448079	C	T	54448079	3	4	64	1	0	0	0	0	1	0	0	0	7313	855	30	1	375	1	HOXC4	12	54448079	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	1440565	54448079	79403816	66	18987										
TMEM5	10329	broad.mit.edu	37	chr12	64196067	64196067	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gaaatgaacattgtgataatGagtggataaacccattcctc	8	7	0	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64196067G>C	uc001srq.1	+	4	729	c.625G>C	c.(625-627)GAG>CAG	p.E209Q	TMEM5_uc001srr.1_Missense_Mutation_p.E106Q|TMEM5_uc001srs.1_5'UTR	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	209	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TTGTGATAATGAGTGGATAAA	0.393													0	0	0	0.006214	0	8	36										C	64196067	G	C	64196067	3	2	64	1	0	0	0	0	1	0	0	0	16171	1291	45	1	639	1	TMEM5	12	64196067	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	9747988	64196067	69655828	67	18988										
OSBPL8	114882	broad.mit.edu	37	chr12	76763454	76763454	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ccattctcctgtgagtggatCaagttcaaataatttgcaag	8	8	3	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:76763454C>G	uc001sye.1	-	20	2683	c.2203G>C	c.(2203-2205)GAT>CAT	p.D735H	OSBPL8_uc001syf.1_Missense_Mutation_p.D693H|OSBPL8_uc001syg.1_Missense_Mutation_p.D693H|OSBPL8_uc001syh.1_Missense_Mutation_p.D710H	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	735					lipid transport		lipid binding			ovary(1)	1						GTGAGTGGATCAAGTTCAAAT	0.358													0	0	0	0.012319	0	17	56										G	76763454	C	G	76763454	3	3	64	1	0	0	0	0	1	0	0	0	11283	826	29	1	486	1	OSBPL8	12	76763454	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	12567387	76763454	57088441	68	18989										
SDSL	113675	broad.mit.edu	37	chr12	113873341	113873341	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	atcacagccggcaagctggtCacacttccagacatcaccag	8	15	3	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:113873341C>G	uc001tvi.2	+	7	861	c.651C>G	c.(649-651)GTC>GTG	p.V217V	SDSL_uc009zwh.2_Silent_p.V217V	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	217					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	GCAAGCTGGTCACACTTCCAG	0.622													0	0	0	0.009718	0	35	180										G	113873341	C	G	113873341	2	3	64	1	0	0	0	0	0	0	0	1	13976	813	29	1		1	SDSL	12	113873341	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	37109887	113873341	19978554	69	18990										
DNAH10	196385	broad.mit.edu	37	chr12	124345688	124345688	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tcaaacatcttcagggaaatCaacaagccaacagacaagaa	6	10	4	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:124345688C>G	uc001uft.3	+	38	6550	c.6525C>G	c.(6523-6525)ATC>ATG	p.I2175M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2175	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCAGGGAAATCAACAAGCCAA	0.463													0	0	0	0.004482	0	7	30										G	124345688	C	G	124345688	3	3	64	1	0	0	0	0	1	0	0	0	4598	816	29	1	6675	1	DNAH10	12	124345688	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	10472347	124345688	9506207	70	18991										
TUBA3C	7278	broad.mit.edu	37	chr13	19751303	19751303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cttctcggctgagatgaccgGggcgtaggtggccaggggga	19	9	1	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr13:19751303G>A	uc009zzj.2	-	4	869	c.820C>T	c.(820-822)CCG>TCG	p.P274S		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	274					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAGATGACCGGGGCGTAGGTG	0.607													0	0	0	0.01441	0	49	173										A	19751303	G	A	19751303	3	1	64	1	0	0	0	0	1	0	0	0	16743	1232	43	2	540	2	TUBA3C	13	19751303	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		19751303	95418575	71	18992										
RB1	5925	broad.mit.edu	37	chr13	48947629	48947629	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	atctgatttcctattttaacGtaagccatatatgaaacatt	4	7	1	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr13:48947629G>A	uc001vcb.2	+	12	1381	c.1215_splice	c.e12+1	p.N405_splice	RB1_uc010act.1_Splice_Site_p.N106_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(14)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.264		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.00499	0	17	29										A	48947629	G	A	48947629	5	1	64	1	0	0	0	0	0	0	1	0	13098	1159	40	2	1262	2	RB1	13	48947629	Splice_Site	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	29196326	48947629	66222249	72	18993										
POTEG	404785	broad.mit.edu	37	chr14	19553680	19553680	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	acttctggagaccacgacgaCtctgctatgaagacactcag	9	12	3	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:19553680C>T	uc001vuz.1	+	1	316	c.264C>T	c.(262-264)GAC>GAT	p.D88D	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	88										ovary(1)	1						ACCACGACGACTCTGCTATGA	0.617													0	0	0	0.001984	0	6	393										T	19553680	C	T	19553680	2	4	64	1	0	0	0	0	0	0	0	1	12266	564	20	2		2	POTEG	14	19553680	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08		19553680	87795860	73	18994										
MDGA2	161357	broad.mit.edu	37	chr14	47530528	47530528	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	agagatgctacacatgtgtaCgtcccaaaatccgtgaattt	8	9	0	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:47530528C>T	uc001wwj.3	-	7	1438	c.1242G>A	c.(1240-1242)ACG>ACA	p.T414T	MDGA2_uc001wwi.3_Silent_p.T185T|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	414	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CACATGTGTACGTCCCAAAAT	0.408													0	0	0	0.01441	0	36	120										T	47530528	C	T	47530528	2	4	64	1	0	0	0	0	0	0	0	1	9407	523	19	2		2	MDGA2	14	47530528	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	27976848	47530528	59819012	74	18995										
OTX2	5015	broad.mit.edu	37	chr14	57268797	57268797	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	agcctgagtataggtcatggGataggacctctgcatgcagg	14	8	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:57268797G>A	uc001xcp.2	-	3	697	c.526C>T	c.(526-528)CCC>TCC	p.P176S	OTX2_uc010aou.2_Missense_Mutation_p.P176S|OTX2_uc001xcq.2_Missense_Mutation_p.P184S	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	176					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					TAGGTCATGGGATAGGACCTC	0.522													0	0	0	0.006122	0	13	42										A	57268797	G	A	57268797	3	1	64	1	0	0	0	0	1	0	0	0	11321	1174	41	1	347	1	OTX2	14	57268797	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	9738269	57268797	50080743	75	18996										
CHAC1	79094	broad.mit.edu	37	chr15	41245807	41245807	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gcaggagtctgcagccccgaAcaccccgcccacctcgcagt	10	19	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:41245807A>T	uc001znh.2	+	1	172	c.152A>T	c.(151-153)AAC>ATC	p.N51I	CHAC1_uc010uct.1_Missense_Mutation_p.N51I	NM_024111	NP_077016	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator-like 1 isoform	51					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCAGCCCCGAACACCCCGCCC	0.687													0	0	0	0.010504	0	13	60										T	41245807	A	T	41245807	3	4	64	1	0	0	0	0	1	0	0	0	3308	43	2	5	154	5	CHAC1	15	41245807	Missense_Mutation	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08		41245807	61285585	76	18997										
KIF23	9493	broad.mit.edu	37	chr15	69709843	69709843	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	actcaaccgaaatggagactAtaaggaggtaattctgattt	9	6	2	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:69709843A>G	uc002asb.2	+	3	320	c.203A>G	c.(202-204)TAT>TGT	p.Y68C	KIF23_uc002asc.2_Missense_Mutation_p.Y68C|KIF23_uc010bii.2_Missense_Mutation_p.I4V|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	68	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						AATGGAGACTATAAGGAGGTA	0.378													0	0	0	0.007835	0	33	75										G	69709843	A	G	69709843	3	3	64	1	0	0	0	0	1	0	0	0	8291	449	16	5	213	5	KIF23	15	69709843	Missense_Mutation	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08	28464036	69709843	32821549	77	18998										
CSK	1445	broad.mit.edu	37	chr15	75094356	75094356	+	Missense_Mutation	SNP	G	G	A													0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	agaaattctccactaagtctGacgtgtggagtttcggaatc							TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:75094356G>A	uc010bkb.1	+	13	1285	c.1102G>A	c.(1102-1104)GAC>AAC	p.D368N	CSK_uc002ays.2_Missense_Mutation_p.D368N|CSK_uc010bkc.1_Missense_Mutation_p.D177N	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	368	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						CACTAAGTCTGACGTGTGGAG	0.532													0	0	0	0.015359	0	26	52										A	75094356	G	A	75094356	3	1	64	1	0	0	0	0	1	0	0	0	3943	1290	45	1	1144	1	CSK	15	75094356	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	5384513	75094356	27437036	78	18999	91	2								
CSK	1445	broad.mit.edu	37	chr15	75094364	75094364	+	Missense_Mutation	SNP	G	G	T													0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tccactaagtctgacgtgtgGagtttcggaatccttctctg							TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:75094364G>T	uc010bkb.1	+	13	1293	c.1110G>T	c.(1108-1110)TGG>TGT	p.W370C	CSK_uc002ays.2_Missense_Mutation_p.W370C|CSK_uc010bkc.1_Missense_Mutation_p.W179C	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	370	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						CTGACGTGTGGAGTTTCGGAA	0.537													1	0	2.87052e-16	0.005524	3.16386e-16	27	52										T	75094364	G	T	75094364	3	4	64	1	0	0	0	0	1	0	0	0	3943	1183	41	3	1152	3	CSK	15	75094364	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	8	75094364	27437028	79	19000	91	2								
PDILT	204474	broad.mit.edu	37	chr16	20370721	20370721	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	caccaccaccaccacctcctCagatgttttcttcttcccag	3	19	3	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:20370721C>T	uc002dhc.1	-	12	1898	c.1675G>A	c.(1675-1677)GAG>AAG	p.E559K		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	559					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						ACCACCTCCTCAGATGTTTTC	0.493													0	0	0	0.01441	0	50	282										T	20370721	C	T	20370721	3	4	64	1	0	0	0	0	1	0	0	0	11674	835	29	1	83	1	PDILT	16	20370721	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08		20370721	69984032	80	19001										
SMTNL2	342527	broad.mit.edu	37	chr17	4496232	4496232	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cacatgttccaggtccaggcGatggaccccctgagattgcc	11	14	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:4496232G>A	uc002fyf.1	+	3	563	c.496G>A	c.(496-498)GAT>AAT	p.D166N	SMTNL2_uc002fye.2_Missense_Mutation_p.D22N	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	166											0				READ - Rectum adenocarcinoma(115;0.0325)		AGGTCCAGGCGATGGACCCCC	0.662													0	0	0	0.006999	0	31	19										A	4496232	G	A	4496232	3	1	64	1	0	0	0	0	1	0	0	0	14816	1058	37	1	506	1	SMTNL2	17	4496232	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		4496232	76698978	81	19002										
TP53	7157	broad.mit.edu	37	chr17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cttgcggagattctcttcctCtgtgcgccggtctctcccag	10	15	3	1	rs112431538		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.007413	0	18	23										T	7577085	C	T	7577085	3	4	64	1	0	0	0	0	1	0	0	0	16378	922	32	1	433	1	TP53	17	7577085	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	3080853	7577085	73618125	82	19003										
EFCAB5	374786	broad.mit.edu	37	chr17	28380460	28380460	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	caacctaaacttaacgaacaGagaacatcaacaccatcacc	3	14	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:28380460G>A	uc002het.2	+	10	1680	c.1488G>A	c.(1486-1488)CAG>CAA	p.Q496Q	EFCAB5_uc010wbi.1_Silent_p.Q239Q|EFCAB5_uc010wbj.1_Silent_p.Q440Q|EFCAB5_uc010wbk.1_Silent_p.Q153Q|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Silent_p.Q375Q|EFCAB5_uc010csf.2_Silent_p.Q375Q	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	496							calcium ion binding			ovary(1)|skin(1)	2						TTAACGAACAGAGAACATCAA	0.393													0	0	0	0.020292	0	12	41										A	28380460	G	A	28380460	2	1	64	1	0	0	0	0	0	0	0	1	4938	933	33	1		1	EFCAB5	17	28380460	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	20803375	28380460	52814750	83	19004										
ZNF652	22834	broad.mit.edu	37	chr17	47395037	47395037	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tgtgccattcctgctacatgCacagcacagttttcaaccag	7	13	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:47395037C>T	uc002iov.3	-	2	515	c.51G>A	c.(49-51)GTG>GTA	p.V17V	ZNF652_uc002iow.2_Silent_p.V17V|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CTGCTACATGCACAGCACAGT	0.448													0	0	0	0.00308	0	5	38										T	47395037	C	T	47395037	2	4	64	1	0	0	0	0	0	0	0	1	18062	697	25	2		2	ZNF652	17	47395037	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	19014577	47395037	33800173	84	19005										
MED13	9969	broad.mit.edu	37	chr17	60028189	60028189	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gacagaaatggcaataccttAagaaaaaggggacactgata	10	6	0	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:60028189A>G	uc002izo.2	-	28	6365	c.6288T>C	c.(6286-6288)CTT>CTC	p.L2096L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2096					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GCAATACCTTAAGAAAAAGGG	0.413													0	0	0	0.01441	0	39	81										G	60028189	A	G	60028189	2	3	64	1	0	0	0	0	0	0	0	1	9430	349	13	5		5	MED13	17	60028189	Silent	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08	12633152	60028189	21167021	85	19006										
ITGB4	3691	broad.mit.edu	37	chr17	73723498	73723498	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tggccagatgttcagggaccGgcgctgcaacacccaggcgg	15	13	1	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:73723498G>A	uc002jpg.2	+	4	363	c.176G>A	c.(175-177)CGG>CAG	p.R59Q	ITGB4_uc002jph.2_Missense_Mutation_p.R59Q|ITGB4_uc010dgo.2_Missense_Mutation_p.R59Q|ITGB4_uc002jpi.3_Missense_Mutation_p.R59Q|ITGB4_uc010dgp.1_Missense_Mutation_p.R59Q|ITGB4_uc002jpj.2_Missense_Mutation_p.R59Q	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	59	PSI.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTCAGGGACCGGCGCTGCAAC	0.637													0	0	0	0.016723	0	10	41										A	73723498	G	A	73723498	3	1	64	1	0	0	0	0	1	0	0	0	7897	1116	39	2	186	2	ITGB4	17	73723498	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	13695309	73723498	7471712	86	19007										
FAM59A	64762	broad.mit.edu	37	chr18	29848220	29848220	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ggggtcttcctcagcaccatCaattttcagaggcaaaggag	11	10	4	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr18:29848220C>T	uc002kxl.2	-	6	2301	c.2245G>A	c.(2245-2247)GAT>AAT	p.D749N	FAM59A_uc002kxk.1_Missense_Mutation_p.D748N	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	749										ovary(1)|skin(1)	2						TCAGCACCATCAATTTTCAGA	0.522													0	0	0	0.004656	0	23	56										T	29848220	C	T	29848220	3	4	64	1	0	0	0	0	1	0	0	0	5592	826	29	1	389	1	FAM59A	18	29848220	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08		29848220	48229028	87	19008										
FEM1A	55527	broad.mit.edu	37	chr19	4792857	4792857	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gggccatggagctgcgtcacCaggggggcgagtacctgccc	17	13	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:4792857C>T	uc002mbf.2	+	1	1130	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	331	TPR 1.				regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCTGCGTCACCAGGGGGGCGA	0.602													0	0	0	0.005443	0	22	40										T	4792857	C	T	4792857	4	4	64	1	0	0	0	0	0	1	0	0	5809	595	21	2	993	2	FEM1A	19	4792857	Nonsense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08		4792857	54336126	88	19009										
ZNF208	7757	broad.mit.edu	37	chr19	22156621	22156621	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aggattgagaacatactaaaAcctttgccacattcttcaca	5	10	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:22156621A>G	uc002nqp.2	-	4	1364	c.1215T>C	c.(1213-1215)GGT>GGC	p.G405G	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATACTAAAACCTTTGCCAC	0.393													0	0	0	0.004672	0	3	62										G	22156621	A	G	22156621	2	3	64	1	0	0	0	0	0	0	0	1	17763	30	2	5		5	ZNF208	19	22156621	Silent	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08	17363764	22156621	36972362	89	19010										
ZNF681	148213	broad.mit.edu	37	chr19	23927146	23927146	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aggtgtgaggacttgttaaaAgctttgccacattcttcaca	9	8	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:23927146A>G	uc002nrk.3	-	4	1348	c.1206T>C	c.(1204-1206)GCT>GCC	p.A402A	ZNF681_uc002nrl.3_Silent_p.A333A|ZNF681_uc002nrj.3_Silent_p.A333A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	402	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACTTGTTAAAAGCTTTGCCAC	0.398													0	0	0	0.001984	0	3	66										G	23927146	A	G	23927146	2	3	64	1	0	0	0	0	0	0	0	1	18085	59	3	5		5	ZNF681	19	23927146	Silent	SNP	A	TCGA-DK-A3IV-01A-22D-A21A-08	1770525	23927146	35201837	90	19011										
ZNF599	148103	broad.mit.edu	37	chr19	35251038	35251038	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tgcactcatagggcttcactCcagcatgaatctgttgatgc	9	11	3	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:35251038C>G	uc010edn.1	-	4	1056	c.668G>C	c.(667-669)GGA>GCA	p.G223A	ZNF599_uc010edm.1_Missense_Mutation_p.G186A	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GGGCTTCACTCCAGCATGAAT	0.473													0	0	0	0.004482	0	6	204										G	35251038	C	G	35251038	3	3	64	1	0	0	0	0	1	0	0	0	18026	855	30	1	1102	1	ZNF599	19	35251038	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	11323892	35251038	23877945	91	19012										
SIPA1L3	23094	broad.mit.edu	37	chr19	38579389	38579389	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aattacttcggcgtggatgaGaagctggggccagtggctgt	16	7	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:38579389G>A	uc002ohk.2	+	4	2072	c.1563G>A	c.(1561-1563)GAG>GAA	p.E521E		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	521					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCGTGGATGAGAAGCTGGGGC	0.587													0	0	0	0.020292	0	15	33										A	38579389	G	A	38579389	2	1	64	1	0	0	0	0	0	0	0	1	14331	933	33	1		1	SIPA1L3	19	38579389	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	3328351	38579389	20549594	92	19013										
LIPE	3991	broad.mit.edu	37	chr19	42931254	42931254	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gttataggcctctggtgtggTtcaggttgccagtctgacct	13	9	3	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:42931254T>C	uc002otr.2	-	1	325	c.48A>G	c.(46-48)GAA>GAG	p.E16E	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	16					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TCTGGTGTGGTTCAGGTTGCC	0.517													0	0	0	0.006214	0	7	28										C	42931254	T	C	42931254	2	2	64	1	0	0	0	0	0	0	0	1	8821	1722	60	5		5	LIPE	19	42931254	Silent	SNP	T	TCGA-DK-A3IV-01A-22D-A21A-08	4351865	42931254	16197729	93	19014										
ZNF229	7772	broad.mit.edu	37	chr19	44933766	44933766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gtttctctccagtgtggaccCtctgatggacaagcaggttt	11	10	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:44933766C>T	uc002oze.1	-	6	1624	c.1190G>A	c.(1189-1191)AGG>AAG	p.R397K	ZNF229_uc010ejk.1_Missense_Mutation_p.R51K|ZNF229_uc010ejl.1_Missense_Mutation_p.R391K	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	397	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				AGTGTGGACCCTCTGATGGAC	0.502													0	0	0	0.013726	0	32	51										T	44933766	C	T	44933766	3	4	64	1	0	0	0	0	1	0	0	0	17779	681	24	2	1291	2	ZNF229	19	44933766	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	2002512	44933766	14195217	94	19015										
ZNF577	84765	broad.mit.edu	37	chr19	52376698	52376698	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cacatccatggggtttctctCctctttcagttctctgatgt	7	12	4	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:52376698C>A	uc010yde.1	-	7	936	c.545G>T	c.(544-546)GGA>GTA	p.G182V	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Missense_Mutation_p.G123V|ZNF577_uc002pxv.2_Missense_Mutation_p.G175V|ZNF577_uc002pxw.2_Missense_Mutation_p.G116V	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GGGTTTCTCTCCTCTTTCAGT	0.468													1	0	0.000602214	0.014758	0.000627134	4	88										A	52376698	C	A	52376698	3	1	64	1	0	0	0	0	1	0	0	0	18006	855	30	3	916	3	ZNF577	19	52376698	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	7442932	52376698	6752285	95	19016										
ZNF611	81856	broad.mit.edu	37	chr19	53209409	53209409	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tacgatggcaggtaagggatGactcctgactgaaggtcttg	14	7	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:53209409G>T	uc002pzz.2	-	7	1216	c.899C>A	c.(898-900)TCA>TAA	p.S300*	ZNF611_uc010eqc.2_Nonsense_Mutation_p.S230*|ZNF611_uc010ydo.1_Nonsense_Mutation_p.S230*|ZNF611_uc010ydr.1_Nonsense_Mutation_p.S231*|ZNF611_uc010ydp.1_Nonsense_Mutation_p.S300*|ZNF611_uc010ydq.1_Nonsense_Mutation_p.S300*|ZNF611_uc002qaa.3_Nonsense_Mutation_p.S230*	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	300	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		GGTAAGGGATGACTCCTGACT	0.413													1	0	7.38237e-10	0.00632	7.96241e-10	27	192										T	53209409	G	T	53209409	4	4	64	1	0	0	0	0	0	1	0	0	18034	1294	45	3	1222	3	ZNF611	19	53209409	Nonsense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	832711	53209409	5919574	96	19017										
ZNF347	84671	broad.mit.edu	37	chr19	53644362	53644362	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tgagtgaagaccttgccacaCtcattacatttgtaaggttt	8	8	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:53644362C>T	uc002qbb.1	-	5	1788	c.1719G>A	c.(1717-1719)GAG>GAA	p.E573E	ZNF347_uc010eql.1_Silent_p.E574E|ZNF347_uc002qbc.1_Silent_p.E574E	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	573	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CCTTGCCACACTCATTACATT	0.408													0	0	0	0.00308	0	5	247										T	53644362	C	T	53644362	2	4	64	1	0	0	0	0	0	0	0	1	17858	564	20	2		2	ZNF347	19	53644362	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	434953	53644362	5484621	97	19018										
ZNF628	89887	broad.mit.edu	37	chr19	55993619	55993619	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	cctcccgccgccgcccccgcGcctggctttgcctgtctgcc	10	23	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:55993619G>T	uc002qld.2	+	3	1612	c.1047G>T	c.(1045-1047)GCG>GCT	p.A349A	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	349	Pro-rich.					nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CCGCCCCCGCGCCTGGCTTTG	0.771													1	0	2.61681e-11	0.020292	2.84273e-11	10	6										T	55993619	G	T	55993619	2	4	64	1	0	0	0	0	0	0	0	1	18049	1074	38	4		4	ZNF628	19	55993619	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	2349257	55993619	3135364	98	19019										
SRC	6714	broad.mit.edu	37	chr20	36012632	36012632	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	agcccgccgagaacgtgcacGgcgctggcgggggcgctttc	17	14	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:36012632G>A	uc002xgx.2	+	4	525	c.76G>A	c.(76-78)GGC>AGC	p.G26S	SRC_uc002xgy.2_Missense_Mutation_p.G26S	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	26					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GAACGTGCACGGCGCTGGCGG	0.741													0	0	0	0.004482	0	4	31										A	36012632	G	A	36012632	3	1	64	1	0	0	0	0	1	0	0	0	15133	1116	39	2	78	2	SRC	20	36012632	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		36012632	27012888	99	19020										
KCNQ2	3785	broad.mit.edu	37	chr20	62044922	62044922	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aacttccgcttggacaccagGaaccgcatgacactgcaggg	11	13	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:62044922G>A	uc002yey.1	-	15	1821	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F	KCNQ2_uc002yez.1_Silent_p.F517F|KCNQ2_uc002yfa.1_Silent_p.F530F|KCNQ2_uc002yfb.1_Silent_p.F520F	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	548	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TGGACACCAGGAACCGCATGA	0.647													0	0	0	0.013726	0	30	85										A	62044922	G	A	62044922	2	1	64	1	0	0	0	0	0	0	0	1	8083	1165	41	1		1	KCNQ2	20	62044922	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08	26032290	62044922	980598	100	19021										
BCL2L13	23786	broad.mit.edu	37	chr22	18210132	18210132	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gagctgtcccctgccagcgaGaagaagcccgtgccgccgtc	13	16	0	2			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:18210132G>A	uc002zmw.2	+	7	1508	c.1290G>A	c.(1288-1290)GAG>GAA	p.E430E	BCL2L13_uc002zmx.2_Silent_p.E268E|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Silent_p.E268E|BCL2L13_uc011agk.1_Silent_p.E306E|BCL2L13_uc010gqz.2_Silent_p.E150E|BCL2L13_uc002zmz.2_Silent_p.E268E|BCL2L13_uc002zna.2_Silent_p.E150E	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	430	B.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTGCCAGCGAGAAGAAGCCCG	0.592													0	0	0	0.016723	0	12	29										A	18210132	G	A	18210132	2	1	64	1	0	0	0	0	0	0	0	1	1371	933	33	1		1	BCL2L13	22	18210132	Silent	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		18210132	33094434	101	19022										
GNAZ	2781	broad.mit.edu	37	chr22	23438065	23438065	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	atcatccacagcggcggcttCaacctggaggcctgcaagga	12	13	2	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:23438065C>T	uc002zwu.1	+	2	720	c.183C>T	c.(181-183)TTC>TTT	p.F61F	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	61						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GCGGCGGCTTCAACCTGGAGG	0.597													0	0	0	0.01441	0	56	98										T	23438065	C	T	23438065	2	4	64	1	0	0	0	0	0	0	0	1	6514	825	29	1		1	GNAZ	22	23438065	Silent	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	5227933	23438065	27866501	102	19023										
NDUFA6	4700	broad.mit.edu	37	chr22	42486786	42486786	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tccacaaccccacccctttgCaagcagcgcgtgcggaccgc	9	19	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:42486786C>G	uc003bcb.2	-	1	103	c.41G>C	c.(40-42)TGC>TCC	p.C14S	uc003bcc.1_5'Flank|uc003bcd.1_5'Flank	NM_002490	NP_002481	P56556	NDUA6_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	14					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	CACCCCTTTGCAAGCAGCGCG	0.622											OREG0026602	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	6	212										G	42486786	C	G	42486786	3	3	64	1	0	0	0	0	1	0	0	0	10269	710	25	4	435	4	NDUFA6	22	42486786	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	19048721	42486786	8817780	103	19024										
SHOX	6473	broad.mit.edu	37	chrX	591697	591697	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	aagcaaggacggtaacggcgGaggcggaggcggcggaggta	21	7	0	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:591697G>A	uc004cph.1	+	2	756	c.65G>A	c.(64-66)GGA>GAA	p.G22E	SHOX_uc004cpi.2_Missense_Mutation_p.G22E	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	22	Poly-Gly.				skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTAACGGCGGAGGCGGAGGC	0.627													0	0	0	0.014758	0	5	220										A	591697	G	A	591697	3	1	64	1	0	0	0	0	1	0	0	0	14288	1174	41	1	67	1	SHOX	23	591697	Missense_Mutation	SNP	G	TCGA-DK-A3IV-01A-22D-A21A-08		591697	154678863	104	19025										
IRS4	8471	broad.mit.edu	37	chrX	107977994	107977994	+	Missense_Mutation	SNP	C	C	A													0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	ccctgaccacctcgggatccCtgtccctcgcctgaacactg							TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107977994C>A	uc004eoc.2	-	1	1614	c.1581G>T	c.(1579-1581)CAG>CAT	p.Q527H		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	527						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTCGGGATCCCTGTCCCTCGC	0.632													1	0	1.10513e-12	0.014323	1.20924e-12	17	133										A	107977994	C	A	107977994	3	1	64	1	0	0	0	0	1	0	0	0	7842	680	24	4	2196	4	IRS4	23	107977994	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	107386297	107977994	47292566	105	19026	92	2	1	86		7	6	240	N	C	3.527003e-18
IRS4	8471	broad.mit.edu	37	chrX	107977998	107977998	+	Missense_Mutation	SNP	C	C	T													0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gaccacctcgggatccctgtCcctcgcctgaacactggttt							TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107977998C>T	uc004eoc.2	-	1	1610	c.1577G>A	c.(1576-1578)GGA>GAA	p.G526E		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	526						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGATCCCTGTCCCTCGCCTGA	0.632													0	0	0	0.012319	0	16	130										T	107977998	C	T	107977998	3	4	64	1	0	0	0	0	1	0	0	0	7842	855	30	1	2200	1	IRS4	23	107977998	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	4	107977998	47292562	106	19027	92	2	1	86		7	6	240	N	C	3.527003e-18
IRS4	8471	broad.mit.edu	37	chrX	107978050	107978050	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	atggctactggagccttggcCatttgagccctggccacctc	11	14	0	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978050C>T	uc004eoc.2	-	1	1558	c.1525G>A	c.(1525-1527)GGC>AGC	p.G509S		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	509						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GAGCCTTGGCCATTTGAGCCC	0.597													0	0	0	0.020292	0	10	93										T	107978050	C	T	107978050	3	4	64	1	0	0	0	0	1	0	0	0	7842	594	21	2	2252	2	IRS4	23	107978050	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	52	107978050	47292510	107	19028			1	86		7	6	240	N	C	3.527003e-18
IRS4	8471	broad.mit.edu	37	chrX	107978105	107978105	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	tttcctgagccccaattgttCataggcatgtagtcacctcc	7	13	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978105C>G	uc004eoc.2	-	1	1503	c.1470G>C	c.(1468-1470)ATG>ATC	p.M490I		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	490	YXXM motif 1.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CCCAATTGTTCATAGGCATGT	0.562													0	0	0	0.016723	0	9	82										G	107978105	C	G	107978105	3	3	64	1	0	0	0	0	1	0	0	0	7842	826	29	1	2307	1	IRS4	23	107978105	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	55	107978105	47292455	108	19029			1	86		7	6	240	N	C	3.527003e-18
IRS4	8471	broad.mit.edu	37	chrX	107978119	107978119	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	attgttcataggcatgtagtCacctccgcttccttcctgat	7	12	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978119C>T	uc004eoc.2	-	1	1489	c.1456G>A	c.(1456-1458)GAC>AAC	p.D486N		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	486						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGCATGTAGTCACCTCCGCTT	0.577													0	0	0	0.004482	0	7	78										T	107978119	C	T	107978119	3	4	64	1	0	0	0	0	1	0	0	0	7842	826	29	1	2321	1	IRS4	23	107978119	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	14	107978119	47292441	109	19030			1	86		7	6	240	N	C	3.527003e-18
IRS4	8471	broad.mit.edu	37	chrX	107978140	107978140	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	acctccgcttccttcctgatCttctttgccctggggattgc	8	15	2	1			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978140C>G	uc004eoc.2	-	1	1468	c.1435G>C	c.(1435-1437)GAT>CAT	p.D479H		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	479						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CCTTCCTGATCTTCTTTGCCC	0.577													0	0	0	0.010729	0	9	64										G	107978140	C	G	107978140	3	3	64	1	0	0	0	0	1	0	0	0	7842	913	32	1	2342	1	IRS4	23	107978140	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	21	107978140	47292420	110	19031			1	86		7	6	240	N	C	3.527003e-18
IRS4	8471	broad.mit.edu	37	chrX	107978233	107978233	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	agctccattgttcggggcttCtgcagggtgccggggacgtg	17	10	1	0			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978233C>T	uc004eoc.2	-	1	1375	c.1342G>A	c.(1342-1344)GAA>AAA	p.E448K		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	448						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TTCGGGGCTTCTGCAGGGTGC	0.612													0	0	0	0.001168	0	6	59										T	107978233	C	T	107978233	3	4	64	1	0	0	0	0	1	0	0	0	7842	922	32	1	2435	1	IRS4	23	107978233	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	93	107978233	47292327	111	19032			1	86		7	6	240	N	C	3.527003e-18
GDI1	2664	broad.mit.edu	37	chrX	153668396	153668396	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.336363636363636	37	4.47576799682419e-10	3.01821120689655	4.258125	2.365625	1	1	25	gggcgttgacccccagactaCcagcatgcgtgacgtctacc	11	15	1	3			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:153668396C>T	uc004fli.3	+	5	839	c.497C>T	c.(496-498)ACC>ATC	p.T166I	GDI1_uc011mzo.1_Missense_Mutation_p.T166I|GDI1_uc004flj.2_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	166					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCCAGACTACCAGCATGCGT	0.552													0	0	0	0.004482	0	6	290										T	153668396	C	T	153668396	3	4	64	1	0	0	0	0	1	0	0	0	6320	507	18	2	515	2	GDI1	23	153668396	Missense_Mutation	SNP	C	TCGA-DK-A3IV-01A-22D-A21A-08	45690163	153668396	1602164	112	19033										
MIB2	142678	broad.mit.edu	37	chr1	1551937	1551937	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcccaaagtttccaggcatCagggctgcagcccaggagcc	12	14	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:1551937C>T	uc001agg.2	+	2	180	c.53C>T	c.(52-54)TCA>TTA	p.S18L	MIB2_uc001agh.2_Missense_Mutation_p.S18L|MIB2_uc001agi.2_Missense_Mutation_p.S18L|MIB2_uc001agj.2_5'UTR|MIB2_uc001agk.2_Missense_Mutation_p.S18L|MIB2_uc001agl.1_5'UTR|MIB2_uc001agm.2_5'UTR|MIB2_uc010nyq.1_5'UTR	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	18					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTCCAGGCATCAGGGCTGCAG	0.652													0	0	0	1	0	13	27										T	1551937	C	T	1551937	3	4	65	1	0	0	0	0	1	0	0	0	9567	838	29	1	230	1	MIB2	1	1551937	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		1551937	247698684	1	19034										
KIAA1751	85452	broad.mit.edu	37	chr1	1903481	1903481	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catgcgtcgcctcatgtactCgtggcactccatctcctcct	7	17	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:1903481C>T	uc001aim.1	-	9	982	c.826G>A	c.(826-828)GAG>AAG	p.E276K	KIAA1751_uc009vkz.1_Missense_Mutation_p.E276K	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	276										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CTCATGTACTCGTGGCACTCC	0.502													0	0	0	1	0	46	106										T	1903481	C	T	1903481	3	4	65	1	0	0	0	0	1	0	0	0	8256	893	31	1	1502	1	KIAA1751	1	1903481	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	351544	1903481	247347140	2	19035										
PRDM16	63976	broad.mit.edu	37	chr1	3348546	3348546	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaggtgtgctgaggaccacGaaggcggtctgttagctttg	16	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:3348546G>T	uc001akf.2	+	16	3618	c.3538G>T	c.(3538-3540)GAA>TAA	p.E1180*	PRDM16_uc001akc.2_Nonsense_Mutation_p.E1179*|PRDM16_uc001akd.2_Nonsense_Mutation_p.E1179*|PRDM16_uc001ake.2_Nonsense_Mutation_p.E1180*|PRDM16_uc009vlh.2_Nonsense_Mutation_p.E880*	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	1180	Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGAGGACCACGAAGGCGGTCT	0.592			T	EVI1	MDS|AML								1	0	4.96729e-08	1	5.15295e-08	16	69										T	3348546	G	T	3348546	4	4	65	1	0	0	0	0	0	1	0	0	12457	1059	37	3	3600	3	PRDM16	1	3348546	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1445065	3348546	245902075	3	19036										
CCDC27	148870	broad.mit.edu	37	chr1	3679963	3679963	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagctgctggcccagctgGaggagtacgagcaggtcatc	16	10	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:3679963G>C	uc001akv.2	+	7	1327	c.1246G>C	c.(1246-1248)GAG>CAG	p.E416Q		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	416	Glu-rich.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		GGCCCAGCTGGAGGAGTACGA	0.522													0	0	0	1	0	30	71										C	3679963	G	C	3679963	3	2	65	1	0	0	0	0	1	0	0	0	2801	1175	41	1	1272	1	CCDC27	1	3679963	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	331417	3679963	245570658	4	19037										
DNAJC11	55735	broad.mit.edu	37	chr1	6727843	6727843	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcaaactcctctcgaatttCagcaggggttctcctccttt	6	14	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:6727843C>T	uc001aof.2	-	4	410	c.304G>A	c.(304-306)GAA>AAA	p.E102K	DNAJC11_uc010nzt.1_Missense_Mutation_p.E64K|DNAJC11_uc001aog.2_Missense_Mutation_p.E102K|DNAJC11_uc010nzu.1_Missense_Mutation_p.E12K	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	102					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCGAATTTCAGCAGGGGTT	0.522													0	0	0	1	0	17	45										T	6727843	C	T	6727843	3	4	65	1	0	0	0	0	1	0	0	0	4630	835	29	1	1427	1	DNAJC11	1	6727843	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3047880	6727843	242522778	5	19038										
SLC45A1	50651	broad.mit.edu	37	chr1	8399747	8399747	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgctgctctgcgattactatCagagtaagaaggtaagtgct	11	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:8399747C>T	uc001apb.2	+	7	1969	c.1969C>T	c.(1969-1971)CAG>TAG	p.Q657*	SLC45A1_uc001apc.2_Nonsense_Mutation_p.Q355*	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	657					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CGATTACTATCAGAGTAAGAA	0.463													0	0	0	1	0	44	148										T	8399747	C	T	8399747	4	4	65	1	0	0	0	0	0	1	0	0	14640	827	29	1	1995	1	SLC45A1	1	8399747	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1671904	8399747	240850874	6	19039										
PGD	5226	broad.mit.edu	37	chr1	10479590	10479590	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagatgcttccagccagcctCatccaggtaagcctgtggag	12	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:10479590C>T	uc001arc.2	+	12	1416	c.1326C>T	c.(1324-1326)CTC>CTT	p.L442L	PGD_uc001ard.2_Silent_p.L362L|PGD_uc010oak.1_Silent_p.L420L|PGD_uc010oal.1_Silent_p.L429L	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	442					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CAGCCAGCCTCATCCAGGTAA	0.592													0	0	0	1	0	36	141										T	10479590	C	T	10479590	2	4	65	1	0	0	0	0	0	0	0	1	11787	813	29	1		1	PGD	1	10479590	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2079843	10479590	238771031	7	19040										
C1orf187	374946	broad.mit.edu	37	chr1	11772015	11772015	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatggttggccctctgcaaaGaagaaaggtatgcccaccta	11	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:11772015G>C	uc001asr.1	+	4	890	c.750G>C	c.(748-750)AAG>AAC	p.K250N		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	250					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		CCTCTGCAAAGAAGAAAGGTA	0.582													0	0	0	1	0	7	16										C	11772015	G	C	11772015	3	2	65	1	0	0	0	0	1	0	0	0	2021	933	33	1	760	1	C1orf187	1	11772015	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1292425	11772015	237478606	8	19041										
VPS13D	55187	broad.mit.edu	37	chr1	12343399	12343399	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaggcccacctctgcgtcccGgaaaaagcaaaaggaagtcc	10	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:12343399G>A	uc001atv.2	+	21	5381	c.5240G>A	c.(5239-5241)CGG>CAG	p.R1747Q	VPS13D_uc001atw.2_Missense_Mutation_p.R1747Q|VPS13D_uc001atx.2_Missense_Mutation_p.R935Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1747					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCTGCGTCCCGGAAAAAGCAA	0.478													0	0	0	1	0	14	44										A	12343399	G	A	12343399	3	1	65	1	0	0	0	0	1	0	0	0	17189	1116	39	2	5318	2	VPS13D	1	12343399	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	571384	12343399	236907222	9	19042										
VPS13D	55187	broad.mit.edu	37	chr1	12516150	12516150	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accatgcagccacaagtggtGaacaccttgtagccggcatc	10	13	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:12516150G>A	uc001atv.2	+	66	12571	c.12430G>A	c.(12430-12432)GAA>AAA	p.E4144K	VPS13D_uc001atw.2_Missense_Mutation_p.E4119K|VPS13D_uc001atx.2_Missense_Mutation_p.E3331K|VPS13D_uc009vnl.2_Intron|VPS13D_uc010obd.1_Missense_Mutation_p.E142K	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	4143					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CACAAGTGGTGAACACCTTGT	0.527													0	0	0	1	0	18	77										A	12516150	G	A	12516150	3	1	65	1	0	0	0	0	1	0	0	0	17189	1291	45	1	12688	1	VPS13D	1	12516150	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	172751	12516150	236734471	10	19043										
PRDM2	7799	broad.mit.edu	37	chr1	14107448	14107448	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgggcctccaacactttcttCttcctcctcttcatcttcct	3	18	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:14107448C>T	uc001avi.2	+	8	4014	c.3158C>T	c.(3157-3159)TCT>TTT	p.S1053F	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S1053F|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S852F|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1053	Poly-Ser.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		ACACTttcttcttcctcctct	0.388													0	0	0	1	0	21	68										T	14107448	C	T	14107448	3	4	65	1	0	0	0	0	1	0	0	0	12458	913	32	1	3184	1	PRDM2	1	14107448	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1591298	14107448	235143173	11	19044										
PRDM2	7799	broad.mit.edu	37	chr1	14107484	14107484	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcctcctcctcttcgttttCttcttcatcttcctcctctt	1	17	6	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:14107484C>G	uc001avi.2	+	8	4050	c.3194C>G	c.(3193-3195)TCT>TGT	p.S1065C	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.S1065C|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.S864C|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1065	Poly-Ser.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		tcttcgttttcttcttcatct	0.368													0	0	0	1	0	21	48										G	14107484	C	G	14107484	3	3	65	1	0	0	0	0	1	0	0	0	12458	913	32	1	3220	1	PRDM2	1	14107484	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	36	14107484	235143137	12	19045										
CASP9	842	broad.mit.edu	37	chr1	15844829	15844829	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaggaagagcctgactccctCgagtctccagatctatgatc	9	12	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:15844829C>T	uc001awn.2	-	2	289	c.194G>A	c.(193-195)CGA>CAA	p.R65Q	CASP9_uc001awm.1_Missense_Mutation_p.R65Q|CASP9_uc001awo.2_Missense_Mutation_p.R65Q|CASP9_uc001awp.2_5'UTR|CASP9_uc009voi.2_5'UTR|CASP9_uc010obm.1_5'UTR|CASP9_uc001awq.2_5'UTR	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein	65	CARD.				activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		CTGACTCCCTCGAGTCTCCAG	0.527													0	0	0	1	0	25	80										T	15844829	C	T	15844829	3	4	65	1	0	0	0	0	1	0	0	0	2679	884	31	1	1088	1	CASP9	1	15844829	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1737345	15844829	233405792	13	19046										
TMEM82	388595	broad.mit.edu	37	chr1	16073402	16073402	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcctgcagagccaggtgcaGacggtgctggtgcgcatggg	19	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:16073402G>A	uc001axc.2	+	5	936	c.798G>A	c.(796-798)CAG>CAA	p.Q266Q		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	266	Leu-rich.|Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCAGGTGCAGACGGTGCTGG	0.682													0	0	0	1	0	6	24										A	16073402	G	A	16073402	2	1	65	1	0	0	0	0	0	0	0	1	16203	933	33	1		1	TMEM82	1	16073402	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	228573	16073402	233177219	14	19047										
CLCNKB	1188	broad.mit.edu	37	chr1	16382217	16382217	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggctgccccacagaaccagtGaccctgaagctgtccccaga	10	16	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:16382217G>A	uc001axw.3	+	18	1973	c.1893G>A	c.(1891-1893)GTG>GTA	p.V631V	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.V631V|CLCNKB_uc001axy.3_Silent_p.V461V	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	631	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CAGAACCAGTGACCCTGAAGC	0.617													0	0	0	1	0	19	100										A	16382217	G	A	16382217	2	1	65	1	0	0	0	0	0	0	0	1	3470	1277	45	1		1	CLCNKB	1	16382217	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	308815	16382217	232868404	15	19048										
ARHGEF19	128272	broad.mit.edu	37	chr1	16534235	16534235	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgcgacacccggtccccgctCatctctacacttcgagcctc	7	20	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:16534235C>T	uc001ayc.1	-	4	869	c.732G>A	c.(730-732)ATG>ATA	p.M244I	ARHGEF19_uc009voo.1_5'Flank|ARHGEF19_uc001ayb.1_5'Flank	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	244					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCCCCGCTCATCTCTACAC	0.672													0	0	0	1	0	21	77										T	16534235	C	T	16534235	3	4	65	1	0	0	0	0	1	0	0	0	902	826	29	1	1728	1	ARHGEF19	1	16534235	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	152018	16534235	232716386	16	19049										
ATP13A2	23400	broad.mit.edu	37	chr1	17328531	17328531	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acccagggacagccctacctCgtccaccagcagctgggggt	12	16	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:17328531C>T	uc001baa.2	-	8	893	c.703G>A	c.(703-705)GAG>AAG	p.E235K	ATP13A2_uc001bab.2_Missense_Mutation_p.E230K|ATP13A2_uc001bac.2_Missense_Mutation_p.E230K|ATP13A2_uc009vpa.1_5'Flank|ATP13A2_uc001bad.1_5'Flank	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	235	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		AGCCCTACCTCGTCCACCAGC	0.383													0	0	0	1	0	11	24										T	17328531	C	T	17328531	3	4	65	1	0	0	0	0	1	0	0	0	1124	893	31	1	3163	1	ATP13A2	1	17328531	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	794296	17328531	231922090	17	19050										
IGSF21	84966	broad.mit.edu	37	chr1	18661423	18661423	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctcagacaatggtccctatGagtgccatgtgggcatctac	10	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:18661423G>T	uc001bau.1	+	4	726	c.343G>T	c.(343-345)GAG>TAG	p.E115*		NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	115	Ig-like 1.					extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		TGGTCCCTATGAGTGCCATGT	0.622													1	0	1.40151e-16	1	1.48112e-16	22	52										T	18661423	G	T	18661423	4	4	65	1	0	0	0	0	0	1	0	0	7599	1291	45	3	357	3	IGSF21	1	18661423	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1332892	18661423	230589198	18	19051										
NBPF3	84224	broad.mit.edu	37	chr1	21795329	21795329	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaacagcagttcagaaacctCaaacagaaatgtcttgtaac	6	9	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:21795329C>G	uc001ber.2	+	3	632	c.282C>G	c.(280-282)CTC>CTG	p.L94L	NBPF3_uc001bes.2_Silent_p.L38L|NBPF3_uc009vqb.2_Silent_p.L94L|NBPF3_uc010odm.1_Intron	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	94						cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCAGAAACCTCAAACAGAAAT	0.473											OREG0013205	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	36	128										G	21795329	C	G	21795329	2	3	65	1	0	0	0	0	0	0	0	1	10197	813	29	1		1	NBPF3	1	21795329	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3133906	21795329	227455292	19	19052										
HSPG2	3339	broad.mit.edu	37	chr1	22203044	22203044	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagctggtgcagtggcgactGacacccatgcagaagcactt	13	11	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:22203044G>A	uc001bfj.2	-	22	2827	c.2787C>T	c.(2785-2787)GTC>GTT	p.V929V	HSPG2_uc009vqd.2_Silent_p.V930V	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	929	Laminin EGF-like 5; first part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGTGGCGACTGACACCCATGC	0.622													0	0	0	1	0	19	52										A	22203044	G	A	22203044	2	1	65	1	0	0	0	0	0	0	0	1	7430	1277	45	1		1	HSPG2	1	22203044	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	407715	22203044	227047577	20	19053										
ZBTB40	9923	broad.mit.edu	37	chr1	22832611	22832611	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atttgttgcacagaatgactGaagagaagacgctgactgct	11	7	0	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:22832611G>A	uc001bft.2	+	7	1748	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	ZBTB40_uc001bfu.2_Missense_Mutation_p.E413K|ZBTB40_uc009vqi.1_Missense_Mutation_p.E301K|ZBTB40_uc001bfv.1_Missense_Mutation_p.E42K	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	413					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CAGAATGACTGAAGAGAAGAC	0.483													0	0	0	1	0	7	51										A	22832611	G	A	22832611	3	1	65	1	0	0	0	0	1	0	0	0	17539	1291	45	1	1255	1	ZBTB40	1	22832611	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	629567	22832611	226418010	21	19054										
CNR2	1269	broad.mit.edu	37	chr1	24201626	24201626	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaggtaggagactagtgctGagaggacccacatgatgccc	14	10	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:24201626G>A	uc001bif.2	-	2	609	c.482C>T	c.(481-483)TCA>TTA	p.S161L		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	161	Helical; Name=4; (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	GACTAGTGCTGAGAGGACCCA	0.587													0	0	0	1	0	23	64										A	24201626	G	A	24201626	3	1	65	1	0	0	0	0	1	0	0	0	3632	1294	45	1	604	1	CNR2	1	24201626	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1369015	24201626	225048995	22	19055										
MAP3K6	9064	broad.mit.edu	37	chr1	27683551	27683551	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcacggctgagcagtgagtCcagaacgaacatccagtgtg	13	10	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:27683551C>A	uc001bny.1	-	24	3562	c.3313G>T	c.(3313-3315)GAC>TAC	p.D1105Y	MAP3K6_uc009vsw.1_Missense_Mutation_p.D1097Y	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1105					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGCAGTGAGTCCAGAACGAAC	0.652													1	0	1.67942e-08	1	1.74647e-08	15	49										A	27683551	C	A	27683551	3	1	65	1	0	0	0	0	1	0	0	0	9254	855	30	3	577	3	MAP3K6	1	27683551	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3481925	27683551	221567070	23	19056										
OPRD1	4985	broad.mit.edu	37	chr1	29189416	29189416	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgcagtgtgcgcctgctgtCgggctccaaggagaaggacc	16	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:29189416C>T	uc001brf.1	+	3	982	c.740C>T	c.(739-741)TCG>TTG	p.S247L		NM_000911	NP_000902	P41143	OPRD_HUMAN	opioid receptor, delta 1	247	Cytoplasmic (Potential).				immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	CGCCTGCTGTCGGGCTCCAAG	0.632													0	0	0	1	0	14	34										T	29189416	C	T	29189416	3	4	65	1	0	0	0	0	1	0	0	0	10884	893	31	1	750	1	OPRD1	1	29189416	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1505865	29189416	220061205	24	19057										
LAPTM5	7805	broad.mit.edu	37	chr1	31210457	31210457	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggatccactcaccttgaaGataaggacagtgatgaaggc	12	8	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:31210457G>C	uc001bsc.2	-	6	691	c.600C>G	c.(598-600)ATC>ATG	p.I200M		NM_006762	NP_006753	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	200	Helical; (Potential).				transport	integral to plasma membrane|lysosomal membrane					0		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		TCACCTTGAAGATAAGGACAG	0.542													0	0	0	1	0	26	57										C	31210457	G	C	31210457	3	2	65	1	0	0	0	0	1	0	0	0	8626	932	33	1	200	1	LAPTM5	1	31210457	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2021041	31210457	218040164	25	19058										
KHDRBS1	10657	broad.mit.edu	37	chr1	32508200	32508200	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccagtgaagggagcatacaGagagcacccatatggacgtt	13	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:32508200G>C	uc001bub.2	+	9	1413	c.1307G>C	c.(1306-1308)AGA>ACA	p.R436T	KHDRBS1_uc001bua.1_Missense_Mutation_p.R397T|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	436					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GGAGCATACAGAGAGCACCCA	0.468													0	0	0	1	0	15	33										C	32508200	G	C	32508200	3	2	65	1	0	0	0	0	1	0	0	0	8146	942	33	1	1341	1	KHDRBS1	1	32508200	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1297743	32508200	216742421	26	19059										
IQCC	55721	broad.mit.edu	37	chr1	32671825	32671825	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgagtatgaggcgattgtacGagaggtcgagggcgacctgg	18	6	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:32671825G>A	uc001bum.2	+	2	160	c.113G>A	c.(112-114)CGA>CAA	p.R38Q	IQCC_uc009vua.2_Missense_Mutation_p.R118Q|IQCC_uc010ogz.1_5'UTR|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	38								p.R38G(1)		ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCGATTGTACGAGAGGTCGAG	0.612													0	0	0	1	0	35	108										A	32671825	G	A	32671825	3	1	65	1	0	0	0	0	1	0	0	0	7804	1058	37	1	359	1	IQCC	1	32671825	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	163625	32671825	216578796	27	19060										
IQCC	55721	broad.mit.edu	37	chr1	32673000	32673000	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acagagacaggaccactggaGagctagaacaggaggatgac	14	8	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:32673000G>C	uc001bum.2	+	5	765	c.718G>C	c.(718-720)GAG>CAG	p.E240Q	IQCC_uc009vua.2_Missense_Mutation_p.E320Q|IQCC_uc010ogz.1_Missense_Mutation_p.E140Q|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	240										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GACCACTGGAGAGCTAGAACA	0.547													0	0	0	1	0	22	49										C	32673000	G	C	32673000	3	2	65	1	0	0	0	0	1	0	0	0	7804	943	33	1	976	1	IQCC	1	32673000	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1175	32673000	216577621	28	19061										
TSSK3	81629	broad.mit.edu	37	chr1	32828367	32828367	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattggggaagggacctactCaaaagtcaaagaagcatttt	10	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:32828367C>G	uc001bvf.2	+	1	506	c.65C>G	c.(64-66)TCA>TGA	p.S22*	uc001bve.1_RNA	NM_052841	NP_443073	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	22	ATP (By similarity).|Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				GGGACCTACTCAAAAGTCAAA	0.507													0	0	0	1	0	52	162										G	32828367	C	G	32828367	4	3	65	1	0	0	0	0	0	1	0	0	16667	838	29	1	67	1	TSSK3	1	32828367	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	155367	32828367	216422254	29	19062										
RBBP4	5928	broad.mit.edu	37	chr1	33138099	33138099	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttagcttccagtggtactGatcgcagactgaatgtctgg	11	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:33138099G>A	uc001bvr.2	+	9	1174	c.1015G>A	c.(1015-1017)GAT>AAT	p.D339N	RBBP4_uc001bvs.2_Missense_Mutation_p.D338N|RBBP4_uc010ohj.1_Missense_Mutation_p.D87N|RBBP4_uc010ohk.1_Missense_Mutation_p.D304N	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	339	WD 5.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CAGTGGTACTGATCGCAGACT	0.358													0	0	0	1	0	16	22										A	33138099	G	A	33138099	3	1	65	1	0	0	0	0	1	0	0	0	13101	1290	45	1	1049	1	RBBP4	1	33138099	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	309732	33138099	216112522	30	19063										
DLGAP3	58512	broad.mit.edu	37	chr1	35370141	35370141	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagaagggaccaccaggctCcccagggggcctcccacccg	13	18	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:35370141C>T	uc001byc.2	-	1	844	c.844G>A	c.(844-846)GAG>AAG	p.E282K		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	282					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCACCAGGCTCCCCAGGGGGC	0.677													0	0	0	1	0	33	146										T	35370141	C	T	35370141	3	4	65	1	0	0	0	0	1	0	0	0	4561	864	30	1	2135	1	DLGAP3	1	35370141	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2232042	35370141	213880480	31	19064										
EIF2C3	192669	broad.mit.edu	37	chr1	36475127	36475127	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaagaagctaacagacaatCagacttccactatgatcaag	6	10	3	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:36475127C>G	uc001bzp.2	+	9	1337	c.1081C>G	c.(1081-1083)CAG>GAG	p.Q361E	EIF2C3_uc001bzq.2_Missense_Mutation_p.Q127E	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	361					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AACAGACAATCAGACTTCCAC	0.343													0	0	0	1	0	13	40										G	36475127	C	G	36475127	3	3	65	1	0	0	0	0	1	0	0	0	5007	827	29	1	1115	1	EIF2C3	1	36475127	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1104986	36475127	212775494	32	19065										
MAP7D1	55700	broad.mit.edu	37	chr1	36641826	36641826	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctgcagctgagcgcatggGagagcagcatcgtggatcgt	16	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:36641826G>C	uc001bzz.2	+	7	1093	c.877G>C	c.(877-879)GAG>CAG	p.E293Q	MAP7D1_uc001caa.2_Missense_Mutation_p.E293Q|MAP7D1_uc001cab.2_Missense_Mutation_p.E256Q|MAP7D1_uc001cac.2_5'UTR|MAP7D1_uc001cad.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	293						cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				GAGCGCATGGGAGAGCAGCAT	0.667													0	0	0	1	0	9	53										C	36641826	G	C	36641826	3	2	65	1	0	0	0	0	1	0	0	0	9267	1175	41	1	903	1	MAP7D1	1	36641826	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	166699	36641826	212608795	33	19066										
CSF3R	1441	broad.mit.edu	37	chr1	36933742	36933742	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagggggctcttccccagctCagggggctcaggcacccact	13	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:36933742C>T	uc001caw.1	-	13	1835	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	CSF3R_uc001cat.1_Missense_Mutation_p.E116K|CSF3R_uc009vvc.1_Missense_Mutation_p.E82K|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Missense_Mutation_p.E553K|CSF3R_uc001cax.1_Missense_Mutation_p.E553K|CSF3R_uc001cay.1_Missense_Mutation_p.E553K	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	553	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTCCCCAGCTCAGGGGGCTCA	0.592													0	0	0	1	0	30	81										T	36933742	C	T	36933742	3	4	65	1	0	0	0	0	1	0	0	0	3937	835	29	1	1063	1	CSF3R	1	36933742	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	291916	36933742	212316879	34	19067										
TRIT1	54802	broad.mit.edu	37	chr1	40313303	40313303	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaattccttgaagccaattGattggaagataccatgttga	9	6	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:40313303G>A	uc010oiz.1	-	7	859	c.845C>T	c.(844-846)TCA>TTA	p.S282L	TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_Intron|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_Missense_Mutation_p.S36L|TRIT1_uc001ceh.3_Missense_Mutation_p.S36L|TRIT1_uc009vvv.2_Missense_Mutation_p.S141L|TRIT1_uc001cei.3_Missense_Mutation_p.S36L|TRIT1_uc001ceq.2_Intron|TRIT1_uc001cek.2_Intron|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Missense_Mutation_p.S200L|TRIT1_uc001cen.2_Missense_Mutation_p.S36L|TRIT1_uc001ceo.2_Missense_Mutation_p.S36L|TRIT1_uc001cep.2_Missense_Mutation_p.S36L	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	282	Interaction with substrate tRNA (By similarity).				tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GAAGCCAATTGATTGGAAGAT	0.378													0	0	0	1	0	43	111										A	40313303	G	A	40313303	3	1	65	1	0	0	0	0	1	0	0	0	16557	1294	45	1	578	1	TRIT1	1	40313303	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3379561	40313303	208937318	35	19068										
ZNF684	127396	broad.mit.edu	37	chr1	41006357	41006357	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtattgggatgtgatgttgGagaactatagaaacctcatc	11	5	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:41006357G>A	uc001cft.1	+	3	366	c.115G>A	c.(115-117)GAG>AAG	p.E39K		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			TGTGATGTTGGAGAACTATAG	0.433													0	0	0	1	0	34	117										A	41006357	G	A	41006357	3	1	65	1	0	0	0	0	1	0	0	0	18088	1175	41	1	121	1	ZNF684	1	41006357	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	693054	41006357	208244264	36	19069										
ERMAP	114625	broad.mit.edu	37	chr1	43308331	43308331	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgtcagcatcctaggctctGagtacttcacgactggctgc	10	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:43308331G>C	uc001cic.1	+	12	1126	c.856G>C	c.(856-858)GAG>CAG	p.E286Q	ERMAP_uc001cid.1_RNA|ERMAP_uc001cie.1_Missense_Mutation_p.E286Q|ERMAP_uc001cif.1_Missense_Mutation_p.E196Q	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	286	Cytoplasmic (Potential).|B30.2/SPRY.		Missing (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCTAGGCTCTGAGTACTTCAC	0.507													0	0	0	1	0	27	124										C	43308331	G	C	43308331	3	2	65	1	0	0	0	0	1	0	0	0	5234	1291	45	1	894	1	ERMAP	1	43308331	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2301974	43308331	205942290	37	19070										
TOE1	114034	broad.mit.edu	37	chr1	45809319	45809319	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtggccaagagccagttctCtcgttcctccaaagcccaca	8	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:45809319C>T	uc009vxq.2	+	8	2061	c.1478C>T	c.(1477-1479)TCT>TTT	p.S493F	TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Missense_Mutation_p.S413F|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	493						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGCCAGTTCTCTCGTTCCTCC	0.532													0	0	0	1	0	28	90										T	45809319	C	T	45809319	3	4	65	1	0	0	0	0	1	0	0	0	16346	913	32	1	1508	1	TOE1	1	45809319	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2500988	45809319	203441302	38	19071										
TESK2	10420	broad.mit.edu	37	chr1	45811142	45811142	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gactggcttcgagacagccaGatggtacgtcttgggcatgg	15	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:45811142G>C	uc001cns.1	-	11	1489	c.1086C>G	c.(1084-1086)ATC>ATG	p.I362M	TESK2_uc009vxr.1_Missense_Mutation_p.I333M|TESK2_uc010olo.1_Missense_Mutation_p.I279M|TESK2_uc009vxs.1_Missense_Mutation_p.I154M	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	362					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					GAGACAGCCAGATGGTACGTC	0.537													0	0	0	1	0	15	57										C	45811142	G	C	45811142	3	2	65	1	0	0	0	0	1	0	0	0	15765	932	33	1	633	1	TESK2	1	45811142	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1823	45811142	203439479	39	19072										
TESK2	10420	broad.mit.edu	37	chr1	45811226	45811226	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accccaggtgctttctccaaGagtcctgaagaataatcaag	8	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:45811226G>A	uc001cns.1	-	11	1405	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	TESK2_uc009vxr.1_Silent_p.L305L|TESK2_uc010olo.1_Silent_p.L251L|TESK2_uc009vxs.1_Silent_p.L126L	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	334					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					CTTTCTCCAAGAGTCCTGAAG	0.438													0	0	0	1	0	12	50										A	45811226	G	A	45811226	2	1	65	1	0	0	0	0	0	0	0	1	15765	929	33	1		1	TESK2	1	45811226	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	84	45811226	203439395	40	19073										
RAD54L	8438	broad.mit.edu	37	chr1	46715746	46715746	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctccttttcggaaacctttGagtcagctaaccaatcaacc	5	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:46715746G>C	uc009vye.2	+	4	279	c.165G>C	c.(163-165)TTG>TTC	p.L55F	RAD54L_uc001cpl.2_Missense_Mutation_p.L55F	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	55					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		GGAAACCTTTGAGTCAGCTAA	0.498								Direct_reversal_of_damage|Homologous_recombination					0	0	0	1	0	32	97										C	46715746	G	C	46715746	3	2	65	1	0	0	0	0	1	0	0	0	12993	1281	45	1	175	1	RAD54L	1	46715746	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	904520	46715746	202534875	41	19074										
DMRTA2	63950	broad.mit.edu	37	chr1	50884475	50884475	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgtagtccatgggtgggcgGaagccgagcgtgggcaccaa	18	10	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:50884475G>A	uc010ona.1	-	2	1587	c.1491C>T	c.(1489-1491)TTC>TTT	p.F497F	DMRTA2_uc010onb.1_Silent_p.F497F	NM_032110	NP_115486	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	497	Ala-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						TGGGTGGGCGGAAGCCGAGCG	0.726													0	0	0	1	0	8	17										A	50884475	G	A	50884475	2	1	65	1	0	0	0	0	0	0	0	1	4589	1165	41	1		1	DMRTA2	1	50884475	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4168729	50884475	198366146	42	19075										
NRD1	4898	broad.mit.edu	37	chr1	52258060	52258060	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcacttaccacaagcagctCcataagcgtatattctctta	5	12	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:52258060C>G	uc001ctc.3	-	27	3338	c.3016G>C	c.(3016-3018)GAG>CAG	p.E1006Q	NRD1_uc009vzb.2_Missense_Mutation_p.E701Q|NRD1_uc001ctd.3_Missense_Mutation_p.E938Q|NRD1_uc001cte.2_Missense_Mutation_p.E874Q|NRD1_uc001ctf.2_Missense_Mutation_p.E938Q	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	937					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						ACAAGCAGCTCCATAAGCGTA	0.488													0	0	0	1	0	12	63										G	52258060	C	G	52258060	3	3	65	1	0	0	0	0	1	0	0	0	10645	864	30	1	671	1	NRD1	1	52258060	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1373585	52258060	196992561	43	19076										
ZCCHC11	23318	broad.mit.edu	37	chr1	52941198	52941198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgcaacattcctcttgactGaaaatggatctagcaaaaga	8	8	2	3	rs143625963	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:52941198G>A	uc001ctx.2	-	13	2267	c.2033C>T	c.(2032-2034)TCA>TTA	p.S678L	ZCCHC11_uc001cty.2_Missense_Mutation_p.S678L|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S678L|ZCCHC11_uc009vze.1_Missense_Mutation_p.S678L|ZCCHC11_uc009vzf.1_Missense_Mutation_p.S437L|ZCCHC11_uc001cub.2_Missense_Mutation_p.S678L	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	678	PAP-associated 1.				miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						CCTCTTGACTGAAAATGGATC	0.393													0	0	0	1	0	8	22										A	52941198	G	A	52941198	3	1	65	1	0	0	0	0	1	0	0	0	17577	1294	45	1	2976	1	ZCCHC11	1	52941198	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	683138	52941198	196309423	44	19077										
PODN	127435	broad.mit.edu	37	chr1	53540288	53540288	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctttgaagggctcccagaGaaggcgtttgagcatctgac	12	10	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:53540288G>C	uc001cuv.2	+	4	568	c.561G>C	c.(559-561)GAG>GAC	p.E187D	PODN_uc001cuw.2_Missense_Mutation_p.E168D|PODN_uc010onr.1_Missense_Mutation_p.E168D|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	139	LRR 2.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GGCTCCCAGAGAAGGCGTTTG	0.607													0	0	0	1	0	62	212										C	53540288	G	C	53540288	3	2	65	1	0	0	0	0	1	0	0	0	12178	933	33	1	575	1	PODN	1	53540288	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	599090	53540288	195710333	45	19078										
SLC1A7	6512	broad.mit.edu	37	chr1	53580452	53580452	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgaggtccaacagggcatCggctgagctcatgatgggct	15	9	1	3	rs149844615	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:53580452C>G	uc001cuy.2	-	3	577	c.409G>C	c.(409-411)GAT>CAT	p.D137H	SLC1A7_uc001cuz.3_Missense_Mutation_p.D137H|uc001cva.1_RNA	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	137	Extracellular (Potential).					integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	AACAGGGCATCGGCTGAGCTC	0.642													0	0	0	1	0	14	42										G	53580452	C	G	53580452	3	3	65	1	0	0	0	0	1	0	0	0	14437	884	31	1	1309	1	SLC1A7	1	53580452	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	40164	53580452	195670169	46	19079										
TACSTD2	4070	broad.mit.edu	37	chr1	59042364	59042364	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcggtggcgcaggtcaatGaggatgtggtgggtgcgcac	21	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:59042364G>A	uc001cyz.3	-	1	803	c.465C>T	c.(463-465)CTC>CTT	p.L155L		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	155	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					GCAGGTCAATGAGGATGTGGT	0.692													0	0	0	1	0	7	22										A	59042364	G	A	59042364	2	1	65	1	0	0	0	0	0	0	0	1	15505	1277	45	1		1	TACSTD2	1	59042364	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5461912	59042364	190208257	47	19080										
FGGY	55277	broad.mit.edu	37	chr1	59844459	59844459	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggataaggcgggacatttCtttgatctcccggacttctt	11	9	3	1	rs146728237	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:59844459C>A	uc001czi.3	+	5	716	c.504C>A	c.(502-504)TTC>TTA	p.F168L	FGGY_uc001czg.2_Missense_Mutation_p.F56L|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.F168L|FGGY_uc001czj.3_Missense_Mutation_p.F168L|FGGY_uc001czk.3_Missense_Mutation_p.F56L|FGGY_uc001czl.3_Missense_Mutation_p.F80L	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	168					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					CGGGACATTTCTTTGATCTCC	0.403													1	0	2.61681e-11	1	2.73642e-11	13	57										A	59844459	C	A	59844459	3	1	65	1	0	0	0	0	1	0	0	0	5871	912	32	3	518	3	FGGY	1	59844459	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	802095	59844459	189406162	48	19081										
INADL	10207	broad.mit.edu	37	chr1	62483543	62483543	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacagataaacaatcagattCtgtatggaagaagtcaccaa	7	7	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:62483543C>T	uc001dab.2	+	29	3997	c.3883C>T	c.(3883-3885)CTG>TTG	p.L1295L	INADL_uc009waf.1_Silent_p.L1295L|INADL_uc001daa.2_Silent_p.L1295L|INADL_uc001dad.3_Silent_p.L992L|INADL_uc001dac.2_RNA|INADL_uc010oot.1_Silent_p.L79L|INADL_uc009wag.2_Silent_p.L79L|INADL_uc010oou.1_Intron	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1295	PDZ 7.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CAATCAGATTCTGTATGGAAG	0.338													0	0	0	1	0	25	53										T	62483543	C	T	62483543	2	4	65	1	0	0	0	0	0	0	0	1	7731	912	32	1		1	INADL	1	62483543	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2639084	62483543	186767078	49	19082										
FAM73A	374986	broad.mit.edu	37	chr1	78269066	78269066	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggacttttcagtaaatattCaggttctgcacagagtttgg	10	6	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:78269066C>G	uc001dhx.2	+	4	517	c.485C>G	c.(484-486)TCA>TGA	p.S162*	FAM73A_uc010ork.1_Nonsense_Mutation_p.S162*|FAM73A_uc010orl.1_Nonsense_Mutation_p.S124*|FAM73A_uc001dhy.1_5'UTR	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	162						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		AGTAAATATTCAGGTTCTGCA	0.303													0	0	0	1	0	10	36										G	78269066	C	G	78269066	4	3	65	1	0	0	0	0	0	1	0	0	5617	838	29	1	499	1	FAM73A	1	78269066	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	15785523	78269066	170981555	50	19083										
CLCA1	1179	broad.mit.edu	37	chr1	86952367	86952367	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcagtgacagggacacactCgccaaaagattacctgcagc	11	12	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:86952367C>T	uc001dlt.2	+	7	1242	c.1113C>T	c.(1111-1113)CTC>CTT	p.L371L	CLCA1_uc001dls.1_Silent_p.L310L	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	371	VWFA.				calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GGGACACACTCGCCAAAAGAT	0.488													0	0	0	1	0	31	82										T	86952367	C	T	86952367	2	4	65	1	0	0	0	0	0	0	0	1	3457	871	31	1		1	CLCA1	1	86952367	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8683301	86952367	162298254	51	19084										
TGFBR3	7049	broad.mit.edu	37	chr1	92177859	92177859	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcgtcagctcacactgtaGaaagagcagtgaggtgttga	13	8	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:92177859G>C	uc001doh.2	-	13	2573	c.2107C>G	c.(2107-2109)CTA>GTA	p.L703V	TGFBR3_uc009wde.2_Intron|TGFBR3_uc010osy.1_Missense_Mutation_p.L661V|TGFBR3_uc001doi.2_Missense_Mutation_p.L702V|TGFBR3_uc001doj.2_Missense_Mutation_p.L702V	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	703	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TCACACTGTAGAAAGAGCAGT	0.488													0	0	0	1	0	16	53										C	92177859	G	C	92177859	3	2	65	1	0	0	0	0	1	0	0	0	15820	933	33	1	468	1	TGFBR3	1	92177859	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5225492	92177859	157072762	52	19085										
GLMN	11146	broad.mit.edu	37	chr1	92752071	92752071	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atttctgatgcaaaatacctGaaaggatcatttccaccttc	5	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:92752071G>A	uc001dor.2	-	7	826	c.711C>T	c.(709-711)TTC>TTT	p.F237F	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Silent_p.F237F	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	237					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		CAAAATACCTGAAAGGATCAT	0.333									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				0	0	0	1	0	16	38										A	92752071	G	A	92752071	2	1	65	1	0	0	0	0	0	0	0	1	6448	1281	45	1		1	GLMN	1	92752071	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	574212	92752071	156498550	53	19086										
GLMN	11146	broad.mit.edu	37	chr1	92752143	92752143	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaagggcatttcaagcttttGaaacaactaaggcataagaa	8	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:92752143G>A	uc001dor.2	-	7	754	c.639C>T	c.(637-639)TTC>TTT	p.F213F	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Silent_p.F213F	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	213					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TCAAGCTTTTGAAACAACTAA	0.318									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				0	0	0	1	0	14	40										A	92752143	G	A	92752143	2	1	65	1	0	0	0	0	0	0	0	1	6448	1281	45	1		1	GLMN	1	92752143	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	72	92752143	156498478	54	19087										
EVI5	7813	broad.mit.edu	37	chr1	92979392	92979392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaaaaccaacaccagtttCctgtaaggaattatctataa	6	8	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:92979392C>T	uc001dox.2	-	18	2264	c.2254G>A	c.(2254-2256)GAA>AAA	p.E752K	EVI5_uc010otf.1_Missense_Mutation_p.E763K	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	752	Targeting to the centrosomes.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		ACACCAGTTTCCTGTAAGGAA	0.428													0	0	0	1	0	17	81										T	92979392	C	T	92979392	3	4	65	1	0	0	0	0	1	0	0	0	5289	864	30	1	182	1	EVI5	1	92979392	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	227249	92979392	156271229	55	19088										
ARHGAP29	9411	broad.mit.edu	37	chr1	94668138	94668138	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttccaaccttcgctttttttCtagttgcttgttgagatttt	6	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:94668138C>G	uc001dqj.3	-	11	1474	c.1105G>C	c.(1105-1107)GAA>CAA	p.E369Q	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.E369Q	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	369	Potential.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CGCTTTTTTTCTAGTTGCTTG	0.393													0	0	0	1	0	29	89										G	94668138	C	G	94668138	3	3	65	1	0	0	0	0	1	0	0	0	878	922	32	1	2732	1	ARHGAP29	1	94668138	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1688746	94668138	154582483	56	19089										
DPYD	1806	broad.mit.edu	37	chr1	97915689	97915689	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgttttctcactgatgagctCaatattcagaaaggagcttt	8	8	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:97915689C>T	uc001drv.2	-	14	1968	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	611					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTGATGAGCTCAATATTCAGA	0.448													0	0	0	1	0	19	81										T	97915689	C	T	97915689	3	4	65	1	0	0	0	0	1	0	0	0	4745	835	29	1	1286	1	DPYD	1	97915689	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3247551	97915689	151334932	57	19090										
AGL	178	broad.mit.edu	37	chr1	100357997	100357997	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttgttacagctttgttcaGaatggttcaacctttgtgaa	8	6	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:100357997G>C	uc001dsi.1	+	24	3493	c.3093G>C	c.(3091-3093)CAG>CAC	p.Q1031H	AGL_uc001dsj.1_Missense_Mutation_p.Q1031H|AGL_uc001dsk.1_Missense_Mutation_p.Q1031H|AGL_uc001dsl.1_Missense_Mutation_p.Q1031H|AGL_uc001dsm.1_Missense_Mutation_p.Q1015H|AGL_uc001dsn.1_Missense_Mutation_p.Q1014H	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1031	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GCTTTGTTCAGAATGGTTCAA	0.348													0	0	0	1	0	9	47										C	100357997	G	C	100357997	3	2	65	1	0	0	0	0	1	0	0	0	384	933	33	1	3252	1	AGL	1	100357997	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2442308	100357997	148892624	58	19091										
SLC35A3	23443	broad.mit.edu	37	chr1	100464840	100464840	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagtctaagagcactgaatCgagtactacatgatgaaatt	9	6	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:100464840C>G	uc001dsp.1	+	3	408	c.211C>G	c.(211-213)CGA>GGA	p.R71G	SLC35A3_uc001dsq.1_Missense_Mutation_p.R71G|SLC35A3_uc009wdy.1_Missense_Mutation_p.R71G|SLC35A3_uc001dsr.1_Missense_Mutation_p.R113G|SLC35A3_uc001dss.1_Translation_Start_Site	NM_012243	NP_036375	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 member 3A	71					UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		AGCACTGAATCGAGTACTACA	0.239													0	0	0	1	0	14	25										G	100464840	C	G	100464840	3	3	65	1	0	0	0	0	1	0	0	0	14572	876	31	1	217	1	SLC35A3	1	100464840	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	106843	100464840	148785781	59	19092										
GPR88	54112	broad.mit.edu	37	chr1	101004970	101004970	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccgggcgcccgccacctacCaggcgctgtaccagaggcgc	13	19	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:101004970C>G	uc001dth.2	+	2	852	c.448C>G	c.(448-450)CAG>GAG	p.Q150E		NM_022049	NP_071332	Q9GZN0	GPR88_HUMAN	G-protein coupled receptor 88	150	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		CGCCACCTACCAGGCGCTGTA	0.741													0	0	0	1	0	3	17										G	101004970	C	G	101004970	3	3	65	1	0	0	0	0	1	0	0	0	6717	595	21	4	450	4	GPR88	1	101004970	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	540130	101004970	148245651	60	19093										
WDR47	22911	broad.mit.edu	37	chr1	109517317	109517317	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caacatgcagctagaatcttCttgacctgtggctaagagac	9	10	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:109517317C>T	uc001dwj.2	-	14	2834	c.2458G>A	c.(2458-2460)GAA>AAA	p.E820K	WDR47_uc001dwl.2_Missense_Mutation_p.E828K|WDR47_uc001dwi.2_Missense_Mutation_p.E821K|WDR47_uc010ovf.1_Missense_Mutation_p.E745K	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	820	WD 5.									ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CTAGAATCTTCTTGACCTGTG	0.438													0	0	0	1	0	7	19										T	109517317	C	T	109517317	3	4	65	1	0	0	0	0	1	0	0	0	17297	922	32	1	309	1	WDR47	1	109517317	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8512347	109517317	139733304	61	19094										
CELSR2	1952	broad.mit.edu	37	chr1	109794764	109794764	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtgttggctgttaccgcctCcgatggcactcggcaggaca	13	12	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:109794764C>T	uc001dxa.3	+	1	2124	c.2063C>T	c.(2062-2064)TCC>TTC	p.S688F		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	688	Cadherin 5.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTTACCGCCTCCGATGGCACT	0.557													0	0	0	1	0	40	65										T	109794764	C	T	109794764	3	4	65	1	0	0	0	0	1	0	0	0	3222	855	30	1	2065	1	CELSR2	1	109794764	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	277447	109794764	139455857	62	19095										
SORT1	6272	broad.mit.edu	37	chr1	109865577	109865577	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaaagtcctccagggaacaGaggcagatggagggctgctt	15	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:109865577G>C	uc001dxm.1	-	15	2050	c.2001C>G	c.(1999-2001)CTC>CTG	p.L667L	SORT1_uc010ovi.1_Silent_p.L530L	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	667	Interactions with LRPAP1 and NGFB.|Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		CCAGGGAACAGAGGCAGATGG	0.488													0	0	0	1	0	11	43										C	109865577	G	C	109865577	2	2	65	1	0	0	0	0	0	0	0	1	14935	929	33	1		1	SORT1	1	109865577	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	70813	109865577	139385044	63	19096										
C1orf103	55791	broad.mit.edu	37	chr1	111492647	111492647	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttttaaattcagcatcactCttcagatgtaatgccttatt	4	8	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:111492647C>T	uc001eaa.2	-	3	1951	c.1695G>A	c.(1693-1695)AAG>AAA	p.K565K	C1orf103_uc001dzz.2_Silent_p.K29K|C1orf103_uc001eab.2_Silent_p.K29K|C1orf103_uc001eac.1_Silent_p.K29K	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		CAGCATCACTCTTCAGATGTA	0.383													0	0	0	1	0	16	61										T	111492647	C	T	111492647	2	4	65	1	0	0	0	0	0	0	0	1	1977	912	32	1		1	C1orf103	1	111492647	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1627070	111492647	137757974	64	19097										
DENND2D	79961	broad.mit.edu	37	chr1	111734819	111734819	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgcatttgtactccaaccatGaagggggtggggcagcagac	14	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:111734819G>A	uc001eak.1	-	8	1115	c.915C>T	c.(913-915)TTC>TTT	p.F305F	DENND2D_uc001eal.1_Silent_p.F302F	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	305	DENN.									ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		CTCCAACCATGAAGGGGGTGG	0.473													0	0	0	1	0	17	52										A	111734819	G	A	111734819	2	1	65	1	0	0	0	0	0	0	0	1	4431	1281	45	1		1	DENND2D	1	111734819	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	242172	111734819	137515802	65	19098										
MOV10	4343	broad.mit.edu	37	chr1	113241408	113241408	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggatgacatcaaggacttGaaggtgacatgctgttccac	11	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:113241408G>C	uc001eck.2	+	17	2850	c.2580G>C	c.(2578-2580)TTG>TTC	p.L860F	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.L860F|MOV10_uc001ecm.2_Missense_Mutation_p.L800F	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	860					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TCAAGGACTTGAAGGTGACAT	0.557													0	0	0	1	0	52	166										C	113241408	G	C	113241408	3	2	65	1	0	0	0	0	1	0	0	0	9718	1281	45	1	2642	1	MOV10	1	113241408	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1506589	113241408	136009213	66	19099										
MOV10	4343	broad.mit.edu	37	chr1	113242322	113242322	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actaggtgggttcagtagaaGaattccaaggccaagaacga	12	7	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:113242322G>A	uc001eck.2	+	18	2869	c.2599G>A	c.(2599-2601)GAA>AAA	p.E867K	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.E867K|MOV10_uc001ecm.2_Missense_Mutation_p.E807K	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	867					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TTCAGTAGAAGAATTCCAAGG	0.453													0	0	0	1	0	36	142										A	113242322	G	A	113242322	3	1	65	1	0	0	0	0	1	0	0	0	9718	943	33	1	2665	1	MOV10	1	113242322	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	914	113242322	136008299	67	19100										
MOV10	4343	broad.mit.edu	37	chr1	113242368	113242368	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catcctcatctccaccgtgcGaagcagccagagctttgtgc	9	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:113242368G>A	uc001eck.2	+	18	2915	c.2645G>A	c.(2644-2646)CGA>CAA	p.R882Q	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.R882Q|MOV10_uc001ecm.2_Missense_Mutation_p.R822Q	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	882					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TCCACCGTGCGAAGCAGCCAG	0.552													0	0	0	1	0	54	171										A	113242368	G	A	113242368	3	1	65	1	0	0	0	0	1	0	0	0	9718	1058	37	1	2711	1	MOV10	1	113242368	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	46	113242368	136008253	68	19101										
MAGI3	260425	broad.mit.edu	37	chr1	114189165	114189165	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccataaatgagcctattcctCagcctatgccttttccaccg	5	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:114189165C>T	uc001edk.2	+	12	2237	c.2056C>T	c.(2056-2058)CAG>TAG	p.Q686*	MAGI3_uc001edh.3_Nonsense_Mutation_p.Q711*|MAGI3_uc001edi.3_Nonsense_Mutation_p.Q686*|MAGI3_uc010owm.1_Nonsense_Mutation_p.Q711*|MAGI3_uc001edj.2_Nonsense_Mutation_p.Q407*	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	711					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTATTCCTCAGCCTATGCC	0.383													0	0	0	1	0	8	45										T	114189165	C	T	114189165	4	4	65	1	0	0	0	0	0	1	0	0	9192	827	29	1	2102	1	MAGI3	1	114189165	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	946797	114189165	135061456	69	19102										
MAGI3	260425	broad.mit.edu	37	chr1	114226163	114226163	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctatacgggcagtaatgctGagcagatcccagatgggaag	14	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:114226163G>A	uc001edk.2	+	21	4154	c.3973G>A	c.(3973-3975)GAG>AAG	p.E1325K	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1350					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGTAATGCTGAGCAGATCCC	0.423													0	0	0	1	0	18	52										A	114226163	G	A	114226163	3	1	65	1	0	0	0	0	1	0	0	0	9192	1291	45	1	4109	1	MAGI3	1	114226163	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	36998	114226163	135024458	70	19103										
TRIM33	51592	broad.mit.edu	37	chr1	114976330	114976330	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aattgcacccttctgattttGaaaagcttcttccaaaaact	4	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:114976330G>C	uc001eew.2	-	5	1033	c.949C>G	c.(949-951)CAA>GAA	p.Q317E	TRIM33_uc010ows.1_5'UTR|TRIM33_uc001eex.2_Missense_Mutation_p.Q317E	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	317	Necessary for oligomerization.|Potential.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTCTGATTTTGAAAAGCTTCT	0.313			T	RET	papillary thyroid								0	0	0	1	0	11	26										C	114976330	G	C	114976330	3	2	65	1	0	0	0	0	1	0	0	0	16504	1299	45	1	2498	1	TRIM33	1	114976330	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	750167	114976330	134274291	71	19104										
CD58	965	broad.mit.edu	37	chr1	117078795	117078795	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctctggtatcatgcattgGacttcaatgcttccattagt	8	9	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:117078795G>C	uc001egm.2	-	3	541	c.420C>G	c.(418-420)GTC>GTG	p.V140V	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Silent_p.V140V|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Silent_p.V140V	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	140	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		TCATGCATTGGACTTCAATGC	0.358													0	0	0	1	0	11	29										C	117078795	G	C	117078795	2	2	65	1	0	0	0	0	0	0	0	1	3025	1161	41	1		1	CD58	1	117078795	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2102465	117078795	132171826	72	19105										
IGSF3	3321	broad.mit.edu	37	chr1	117142914	117142914	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acactgcaagtcaaaggagtCgctgtaggtcacccccggtg	12	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:117142914C>T	uc001egr.1	-	7	2383	c.1678G>A	c.(1678-1680)GAC>AAC	p.D560N	IGSF3_uc001egq.1_Missense_Mutation_p.D580N|IGSF3_uc001egs.1_Missense_Mutation_p.D233N	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	560	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TCAAAGGAGTCGCTGTAGGTC	0.587													0	0	0	1	0	16	38										T	117142914	C	T	117142914	3	4	65	1	0	0	0	0	1	0	0	0	7601	884	31	1	1926	1	IGSF3	1	117142914	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	64119	117142914	132107707	73	19106										
PTGFRN	5738	broad.mit.edu	37	chr1	117509931	117509931	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagtctctccaatcctattGagatagacttccaaacctca	4	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:117509931G>C	uc001egv.1	+	6	2175	c.2038G>C	c.(2038-2040)GAG>CAG	p.E680Q		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	680	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		CAATCCTATTGAGATAGACTT	0.522													0	0	0	1	0	21	69										C	117509931	G	C	117509931	3	2	65	1	0	0	0	0	1	0	0	0	12750	1291	45	1	2060	1	PTGFRN	1	117509931	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	367017	117509931	131740690	74	19107										
SPAG17	200162	broad.mit.edu	37	chr1	118535110	118535110	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttaagggaaacctgcagcctCagtttcacctcattctttat	6	11	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:118535110C>G	uc001ehk.2	-	36	5408	c.5340G>C	c.(5338-5340)CTG>CTC	p.L1780L		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1780						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCTGCAGCCTCAGTTTCACCT	0.463													0	0	0	1	0	24	69										G	118535110	C	G	118535110	2	3	65	1	0	0	0	0	0	0	0	1	14979	813	29	1		1	SPAG17	1	118535110	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1025179	118535110	130715511	75	19108										
ADAM30	11085	broad.mit.edu	37	chr1	120436660	120436660	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgctttagattcttcctgtCcagtttttgctttagattct	6	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:120436660C>T	uc001eij.2	-	1	2454	c.2300G>A	c.(2299-2301)GGA>GAA	p.G767E		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	767	4.|Cytoplasmic (Potential).|5 X 9 AA approximate repeats.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TTCTTCCTGTCCAGTTTTTGC	0.358													0	0	0	1	0	54	190										T	120436660	C	T	120436660	3	4	65	1	0	0	0	0	1	0	0	0	248	855	30	1	76	1	ADAM30	1	120436660	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1901550	120436660	128813961	76	19109										
PDE4DIP	9659	broad.mit.edu	37	chr1	144876029	144876029	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttctcacttttatgatcctCtgtaaaccaaatttagaaag	4	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:144876029C>G	uc001elw.3	-	29	4943	c.4652_splice	c.e29-1	p.K1551_splice	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Splice_Site_p.K1507_splice|PDE4DIP_uc001elv.3_Splice_Site_p.K558_splice	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform						cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTATGATCCTCTGTAAACCAA	0.458			T	PDGFRB	MPD								0	0	0	1	0	37	288										G	144876029	C	G	144876029	5	3	65	1	0	0	0	0	0	0	1	0	11643	927	32	1	2453	1	PDE4DIP	1	144876029	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	24439369	144876029	104374592	77	19110										
NOTCH2NL	388677	broad.mit.edu	37	chr1	145273377	145273377	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttgtgtctcgaccttgcctGaatggcggcacatgccatat	10	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:145273377G>C	uc001emn.3	+	3	601	c.231G>C	c.(229-231)CTG>CTC	p.L77L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Silent_p.L77L|NOTCH2NL_uc001emo.2_Silent_p.L77L|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	77	EGF-like 3.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GACCTTGCCTGAATGGCGGCA	0.532													0	0	0	1	0	40	574										C	145273377	G	C	145273377	2	2	65	1	0	0	0	0	0	0	0	1	10549	1277	45	1		1	NOTCH2NL	1	145273377	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	397348	145273377	103977244	78	19111										
BCL9	607	broad.mit.edu	37	chr1	147091378	147091378	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcccgagcagatagcgtggCtgaaactgcagcaggagttt	13	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:147091378C>T	uc001epq.2	+	8	2157	c.1417C>T	c.(1417-1419)CTG>TTG	p.L473L	BCL9_uc010ozr.1_Silent_p.L399L	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	473	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GATAGCGTGGCTGAAACTGCA	0.517			T	IGH@|IGL@	B-ALL								0	0	0	1	0	34	84										T	147091378	C	T	147091378	2	4	65	1	0	0	0	0	0	0	0	1	1381	796	28	2		2	BCL9	1	147091378	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1818001	147091378	102159243	79	19112										
BCL9	607	broad.mit.edu	37	chr1	147091483	147091483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtccatcagcacgggcctCggggagtggtccgaggaccc	16	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:147091483C>T	uc001epq.2	+	8	2262	c.1522C>T	c.(1522-1524)CGG>TGG	p.R508W	BCL9_uc010ozr.1_Missense_Mutation_p.R434W	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	508	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GCACGGGCCTCGGGGAGTGGT	0.567			T	IGH@|IGL@	B-ALL								0	0	0	1	0	36	152										T	147091483	C	T	147091483	3	4	65	1	0	0	0	0	1	0	0	0	1381	875	31	1	1540	1	BCL9	1	147091483	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	105	147091483	102159138	80	19113										
HORMAD1	84072	broad.mit.edu	37	chr1	150679155	150679155	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attcgttctctctcagtggtCacttttactttgaagatgtg	8	8	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:150679155C>G	uc001evk.1	-	10	784	c.678G>C	c.(676-678)GTG>GTC	p.V226V	HORMAD1_uc001evl.1_Silent_p.V219V|HORMAD1_uc001evm.1_Silent_p.V146V	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	226	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TCTCAGTGGTCACTTTTACTT	0.348													0	0	0	1	0	19	82										G	150679155	C	G	150679155	2	3	65	1	0	0	0	0	0	0	0	1	7286	813	29	1		1	HORMAD1	1	150679155	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3587672	150679155	98571466	81	19114										
ANXA9	8416	broad.mit.edu	37	chr1	150956496	150956496	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgtgctgaccaaccggagcaGagagcaaaggcagctcatct	12	12	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:150956496G>C	uc001ewa.2	+	5	688	c.218G>C	c.(217-219)AGA>ACA	p.R73T		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	73	Annexin 1.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AACCGGAGCAGAGAGCAAAGG	0.587													0	0	0	1	0	4	27										C	150956496	G	C	150956496	3	2	65	1	0	0	0	0	1	0	0	0	725	942	33	1	228	1	ANXA9	1	150956496	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	277341	150956496	98294125	82	19115										
SEMA6C	10500	broad.mit.edu	37	chr1	151107335	151107335	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccatccacagtatgggtcctGagaagccaaacagctcctag	9	13	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:151107335G>C	uc001ewu.2	-	16	1897	c.1597C>G	c.(1597-1599)CAG>GAG	p.Q533E	SEMA6C_uc001ewv.2_Missense_Mutation_p.Q533E|SEMA6C_uc001eww.2_Missense_Mutation_p.Q493E|SEMA6C_uc010pcq.1_Missense_Mutation_p.Q533E	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	533	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATGGGTCCTGAGAAGCCAAA	0.522													0	0	0	1	0	18	65										C	151107335	G	C	151107335	3	2	65	1	0	0	0	0	1	0	0	0	14041	1299	45	1	1311	1	SEMA6C	1	151107335	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	150839	151107335	98143286	83	19116										
SEMA6C	10500	broad.mit.edu	37	chr1	151108595	151108595	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catcagggaggtctcgggaaGaggagaacaaggcagctccc							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:151108595G>A	uc001ewu.2	-	13	1451	c.1151C>T	c.(1150-1152)TCT>TTT	p.S384F	SEMA6C_uc001ewv.2_Missense_Mutation_p.S384F|SEMA6C_uc001eww.2_Missense_Mutation_p.S344F|SEMA6C_uc010pcq.1_Missense_Mutation_p.S384F	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	384	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTCTCGGGAAGAGGAGAACAA	0.592													0	0	0	1	0	13	77										A	151108595	G	A	151108595	3	1	65	1	0	0	0	0	1	0	0	0	14041	942	33	1	1769	1	SEMA6C	1	151108595	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1260	151108595	98142026	84	19117	93	2								
SEMA6C	10500	broad.mit.edu	37	chr1	151108598	151108598	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagggaggtctcgggaagagGagaacaaggcagctccccct							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:151108598G>A	uc001ewu.2	-	13	1448	c.1148C>T	c.(1147-1149)TCC>TTC	p.S383F	SEMA6C_uc001ewv.2_Missense_Mutation_p.S383F|SEMA6C_uc001eww.2_Missense_Mutation_p.S343F|SEMA6C_uc010pcq.1_Missense_Mutation_p.S383F	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	383	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCGGGAAGAGGAGAACAAGGC	0.592													0	0	0	1	0	11	77										A	151108598	G	A	151108598	3	1	65	1	0	0	0	0	1	0	0	0	14041	1174	41	1	1772	1	SEMA6C	1	151108598	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3	151108598	98142023	85	19118	93	2								
POGZ	23126	broad.mit.edu	37	chr1	151378586	151378586	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtactactcgaagcttcttCacagacagctgctccttttt	6	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:151378586C>T	uc001eyd.1	-	19	3231	c.2925G>A	c.(2923-2925)GTG>GTA	p.V975V	POGZ_uc001eye.1_Silent_p.V922V|POGZ_uc010pdb.1_Silent_p.V966V|POGZ_uc001eyf.1_Silent_p.V931V|POGZ_uc010pdc.1_Silent_p.V913V|POGZ_uc009wmv.1_Silent_p.V880V|POGZ_uc010pdd.1_Silent_p.V466V	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	975					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GAAGCTTCTTCACAGACAGCT	0.517													0	0	0	1	0	35	112										T	151378586	C	T	151378586	2	4	65	1	0	0	0	0	0	0	0	1	12186	813	29	1		1	POGZ	1	151378586	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	269988	151378586	97872035	86	19119										
CGN	57530	broad.mit.edu	37	chr1	151492649	151492649	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttttttaacagttcaaatCaactccagacctccttcgag	4	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:151492649C>G	uc009wmw.2	+	3	1025	c.881C>G	c.(880-882)TCA>TGA	p.S294*		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	288	Interacts with ZO-2.|Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			CAGTTCAAATCAACTCCAGAC	0.438													0	0	0	1	0	9	41										G	151492649	C	G	151492649	4	3	65	1	0	0	0	0	0	1	0	0	3303	838	29	1	887	1	CGN	1	151492649	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	114063	151492649	97757972	87	19120										
TCHH	7062	broad.mit.edu	37	chr1	152085023	152085023	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctttgctgctgtttctcctCgcggcccttcctcctcagct	7	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:152085023C>T	uc001ezp.2	-	2	670	c.670G>A	c.(670-672)GAG>AAG	p.E224K	TCHH_uc009wne.1_Missense_Mutation_p.E224K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	224					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTTTCTCCTCGCGGCCCTTC	0.572													0	0	0	1	0	68	229										T	152085023	C	T	152085023	3	4	65	1	0	0	0	0	1	0	0	0	15697	893	31	1	5165	1	TCHH	1	152085023	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	592374	152085023	97165598	88	19121										
RPTN	126638	broad.mit.edu	37	chr1	152128074	152128074	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttggccttgtccgtctggctGaccataatgataactctggt	10	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:152128074G>A	uc001ezs.1	-	3	1566	c.1501C>T	c.(1501-1503)CAG>TAG	p.Q501*		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	501	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CCGTCTGGCTGACCATAATGA	0.507													0	0	0	1	0	204	672										A	152128074	G	A	152128074	4	1	65	1	0	0	0	0	0	1	0	0	13664	1299	45	1	857	1	RPTN	1	152128074	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	43051	152128074	97122547	89	19122										
HRNR	388697	broad.mit.edu	37	chr1	152187713	152187713	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccgtgttgtccgtagccaGaggagtgacctgagccagac	14	11	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:152187713G>T	uc001ezt.1	-	3	6468	c.6392C>A	c.(6391-6393)TCT>TAT	p.S2131Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2131					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCGTAGCCAGAGGAGTGACC	0.567													1	0	1.36615e-20	1	1.45282e-20	19	531										T	152187713	G	T	152187713	3	4	65	1	0	0	0	0	1	0	0	0	7359	942	33	3	2164	3	HRNR	1	152187713	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	59639	152187713	97062908	90	19123										
FLG	2312	broad.mit.edu	37	chr1	152283449	152283449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaacccagggtgtctggagcCatctcttgactgctcccgag	12	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:152283449C>T	uc001ezu.1	-	3	3949	c.3913G>A	c.(3913-3915)GGC>AGC	p.G1305S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1305	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tgtctggagccatctcttgac	0.378									Ichthyosis				0	0	0	1	0	82	258										T	152283449	C	T	152283449	3	4	65	1	0	0	0	0	1	0	0	0	5922	594	21	2	8276	2	FLG	1	152283449	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	95736	152283449	96967172	91	19124										
FLAD1	80308	broad.mit.edu	37	chr1	154956263	154956263	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagaagactagggtcttcctCgaaggaagcacgcgcacgcc	13	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:154956263C>G	uc001fgf.1	+	1	447	c.93C>G	c.(91-93)CTC>CTG	p.L31L	FLAD1_uc001fgc.2_Intron|FLAD1_uc001fgd.1_Silent_p.L31L|FLAD1_uc001fge.1_Intron|FLAD1_uc001fgg.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	31					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGGTCTTCCTCGAAGGAAGCA	0.552													0	0	0	1	0	36	101										G	154956263	C	G	154956263	2	3	65	1	0	0	0	0	0	0	0	1	5920	871	31	1		1	FLAD1	1	154956263	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2672814	154956263	94294358	92	19125										
DCST2	127579	broad.mit.edu	37	chr1	155001832	155001832	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gataaggttgaaggtctccaGaatgtaaaaaaacttctccc	8	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:155001832G>A	uc001fgm.2	-	8	1299	c.1219C>T	c.(1219-1221)CTG>TTG	p.L407L	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	407	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AAGGTCTCCAGAATGTAAAAA	0.547													0	0	0	1	0	35	102										A	155001832	G	A	155001832	2	1	65	1	0	0	0	0	0	0	0	1	4303	933	33	1		1	DCST2	1	155001832	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	45569	155001832	94248789	93	19126										
ASH1L	55870	broad.mit.edu	37	chr1	155319120	155319120	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagtcagtgaaaaatacctCagcattccgaaagactttga	8	8	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:155319120C>T	uc009wqq.2	-	19	8047	c.7567G>A	c.(7567-7569)GAG>AAG	p.E2523K	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.E2518K|MIR555_hsa-mir-555|MI0003561_5'Flank	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2523	Bromo.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AAAAATACCTCAGCATTCCGA	0.378													0	0	0	1	0	15	44										T	155319120	C	T	155319120	3	4	65	1	0	0	0	0	1	0	0	0	1041	835	29	1	1382	1	ASH1L	1	155319120	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	317288	155319120	93931501	94	19127										
SEMA4A	64218	broad.mit.edu	37	chr1	156146338	156146338	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacaatggctccctcttgctGatagtgcaggatggagttgg	13	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:156146338G>A	uc001fnl.2	+	15	1940	c.1836G>A	c.(1834-1836)CTG>CTA	p.L612L	SEMA4A_uc009wrq.2_Silent_p.L612L|SEMA4A_uc001fnm.2_Silent_p.L612L|SEMA4A_uc001fnn.2_Silent_p.L480L|SEMA4A_uc001fno.2_Silent_p.L612L	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	612	Extracellular (Potential).|Ig-like C2-type.				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCCTCTTGCTGATAGTGCAGG	0.557													0	0	0	1	0	30	76										A	156146338	G	A	156146338	2	1	65	1	0	0	0	0	0	0	0	1	14031	1277	45	1		1	SEMA4A	1	156146338	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	827218	156146338	93104283	95	19128										
SEMA4A	64218	broad.mit.edu	37	chr1	156146608	156146608	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaggagccctcatcatcctCgtggcctccccattgagagc	9	16	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:156146608C>T	uc001fnl.2	+	15	2210	c.2106C>T	c.(2104-2106)CTC>CTT	p.L702L	SEMA4A_uc009wrq.2_Silent_p.L702L|SEMA4A_uc001fnm.2_Silent_p.L702L|SEMA4A_uc001fnn.2_Silent_p.L570L|SEMA4A_uc001fno.2_Silent_p.L702L	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	702	Helical; (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TCATCATCCTCGTGGCCTCCC	0.632													0	0	0	1	0	19	87										T	156146608	C	T	156146608	2	4	65	1	0	0	0	0	0	0	0	1	14031	871	31	1		1	SEMA4A	1	156146608	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	270	156146608	93104013	96	19129										
SMG5	23381	broad.mit.edu	37	chr1	156247731	156247731	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttacctttttgttagtcttGataagctggataacttcata	6	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:156247731G>A	uc001foc.3	-	3	431	c.282C>T	c.(280-282)ATC>ATT	p.I94I		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	94					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TGTTAGTCTTGATAAGCTGGA	0.478													0	0	0	1	0	65	223										A	156247731	G	A	156247731	2	1	65	1	0	0	0	0	0	0	0	1	14796	1280	45	1		1	SMG5	1	156247731	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	101123	156247731	93002890	97	19130										
C1orf182	128229	broad.mit.edu	37	chr1	156316677	156316677	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaacatttacaggcatctgtGacacaactggctcctgggag	11	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:156316677G>A	uc001foo.2	+	4	644	c.282G>A	c.(280-282)GTG>GTA	p.V94V	C1orf182_uc009wry.2_Silent_p.V94V|C1orf182_uc001fop.3_Silent_p.V94V	NM_144627	NP_653228	Q96A04	CA182_HUMAN	SSTK-interacting protein	94											0	Hepatocellular(266;0.158)					AGGCATCTGTGACACAACTGG	0.468													0	0	0	1	0	32	102										A	156316677	G	A	156316677	2	1	65	1	0	0	0	0	0	0	0	1	2018	1277	45	1		1	C1orf182	1	156316677	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	68946	156316677	92933944	98	19131										
APOA1BP	128240	broad.mit.edu	37	chr1	156562243	156562243	+	Silent	SNP	C	C	T													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatggaggagatggtctggtCtgtgctcgacacctcaaact							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:156562243C>T	uc001fph.2	+	3	417	c.378C>T	c.(376-378)GTC>GTT	p.V126V	APOA1BP_uc001fpg.2_Silent_p.V126V|APOA1BP_uc001fpi.2_Silent_p.V126V|APOA1BP_uc001fpj.2_Silent_p.V43V|APOA1BP_uc001fpk.2_Silent_p.V23V|APOA1BP_uc010php.1_Silent_p.V23V	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	126	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATGGTCTGGTCTGTGCTCGAC	0.582													0	0	0	1	0	34	122										T	156562243	C	T	156562243	2	4	65	1	0	0	0	0	0	0	0	1	781	900	32	1		1	APOA1BP	1	156562243	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	245566	156562243	92688378	99	19132	94	2								
APOA1BP	128240	broad.mit.edu	37	chr1	156562250	156562250	+	Missense_Mutation	SNP	C	C	G													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagatggtctggtctgtgctCgacacctcaaactctttgtg							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:156562250C>G	uc001fph.2	+	3	424	c.385C>G	c.(385-387)CGA>GGA	p.R129G	APOA1BP_uc001fpg.2_Missense_Mutation_p.R129G|APOA1BP_uc001fpi.2_Missense_Mutation_p.R129G|APOA1BP_uc001fpj.2_Missense_Mutation_p.R46G|APOA1BP_uc001fpk.2_Missense_Mutation_p.R26G|APOA1BP_uc010php.1_Missense_Mutation_p.R26G	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	129	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGTCTGTGCTCGACACCTCAA	0.587													0	0	0	1	0	30	126										G	156562250	C	G	156562250	3	3	65	1	0	0	0	0	1	0	0	0	781	876	31	1	395	1	APOA1BP	1	156562250	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7	156562250	92688371	100	19133	94	2								
FCRL1	115350	broad.mit.edu	37	chr1	157776905	157776905	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aactcaccggcaggttcacaGagtggagctgggagagaatt	14	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:157776905G>A	uc001frg.2	-	2	152	c.39C>T	c.(37-39)CTC>CTT	p.L13L	FCRL1_uc001frh.2_Silent_p.L13L|FCRL1_uc001fri.2_Silent_p.L13L|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	13						integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CAGGTTCACAGAGTGGAGCTG	0.478													0	0	0	1	0	15	45										A	157776905	G	A	157776905	2	1	65	1	0	0	0	0	0	0	0	1	5794	929	33	1		1	FCRL1	1	157776905	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1214655	157776905	91473716	101	19134										
KIRREL	55243	broad.mit.edu	37	chr1	158061274	158061274	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgtcatggaggccgactttCagactcactacaactgcacc	8	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:158061274C>T	uc001frn.3	+	11	1803	c.1399C>T	c.(1399-1401)CAG>TAG	p.Q467*	KIRREL_uc010pib.1_Nonsense_Mutation_p.Q367*|KIRREL_uc009wsq.2_Nonsense_Mutation_p.Q303*|KIRREL_uc001fro.3_Nonsense_Mutation_p.Q281*	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	467	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					GGCCGACTTTCAGACTCACTA	0.592													0	0	0	1	0	39	113										T	158061274	C	T	158061274	4	4	65	1	0	0	0	0	0	1	0	0	8324	827	29	1	1441	1	KIRREL	1	158061274	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	284369	158061274	91189347	102	19135										
SPTA1	6708	broad.mit.edu	37	chr1	158582706	158582706	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgatgttttctgactccttGtcaatcaggaaagcagtata	8	7	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:158582706G>C	uc001fst.1	-	51	7234	c.7035C>G	c.(7033-7035)GAC>GAG	p.D2345E		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2345	EF-hand 2.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTGACTCCTTGTCAATCAGGA	0.478													0	0	0	1	0	10	44										C	158582706	G	C	158582706	3	2	65	1	0	0	0	0	1	0	0	0	15115	1368	48	4	232	4	SPTA1	1	158582706	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	521432	158582706	90667915	103	19136										
NCSTN	23385	broad.mit.edu	37	chr1	160323984	160323984	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctcaggaggccaaatcagtCccagcctctcccaccatctt	6	18	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:160323984C>T	uc001fvx.2	+	11	1380	c.1256C>T	c.(1255-1257)TCC>TTC	p.S419F	NCSTN_uc001fvy.2_Missense_Mutation_p.S399F|NCSTN_uc010pjf.1_Missense_Mutation_p.S281F|NCSTN_uc001fvz.2_Missense_Mutation_p.S199F|NCSTN_uc010pjg.1_Missense_Mutation_p.S161F	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	419	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCAAATCAGTCCCAGCCTCTC	0.552													0	0	0	1	0	26	95										T	160323984	C	T	160323984	3	4	65	1	0	0	0	0	1	0	0	0	10241	855	30	1	1298	1	NCSTN	1	160323984	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1741278	160323984	88926637	104	19137										
PFDN2	5202	broad.mit.edu	37	chr1	161071873	161071873	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctccaaagcgggcagcacctCtttgacagttcgctccacca	8	16	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:161071873C>G	uc001fxu.2	-	3	303	c.253G>C	c.(253-255)GAG>CAG	p.E85Q		NM_012394	NP_036526	Q9UHV9	PFD2_HUMAN	prefoldin subunit 2	85					'de novo' posttranslational protein folding	prefoldin complex	unfolded protein binding				0	all_cancers(52;1.84e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GGCAGCACCTCTTTGACAGTT	0.403													0	0	0	1	0	19	49										G	161071873	C	G	161071873	3	3	65	1	0	0	0	0	1	0	0	0	11756	922	32	1	219	1	PFDN2	1	161071873	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	747889	161071873	88178748	105	19138										
PPOX	5498	broad.mit.edu	37	chr1	161137269	161137269	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccctgcatgccctacccactGgcctcaggtaacaccagcac	7	19	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:161137269G>T	uc001fyj.2	+	4	621	c.331G>T	c.(331-333)GGC>TGC	p.G111C	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Missense_Mutation_p.G111C|PPOX_uc001fyl.2_Missense_Mutation_p.G77C|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_5'UTR|PPOX_uc001fyh.2_5'UTR|PPOX_uc010pkg.1_5'UTR|PPOX_uc009wuc.1_5'UTR|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_5'UTR	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	111					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCTACCCACTGGCCTCAGGTA	0.502									Porphyria_Variegata				1	0	0.000157383	1	0.000159646	8	44										T	161137269	G	T	161137269	3	4	65	1	0	0	0	0	1	0	0	0	12348	1348	47	4	341	4	PPOX	1	161137269	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	65396	161137269	88113352	106	19139										
ATF6	22926	broad.mit.edu	37	chr1	161753803	161753803	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagatattaaggcagaacctCagccactttctccagcctcc	6	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:161753803C>T	uc001gbr.2	+	4	338	c.271C>T	c.(271-273)CAG>TAG	p.Q91*	ATF6_uc001gbq.1_Nonsense_Mutation_p.Q91*	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	91	Cytoplasmic (Potential).|Transcription activation.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGCAGAACCTCAGCCACTTTC	0.398													0	0	0	1	0	24	110										T	161753803	C	T	161753803	4	4	65	1	0	0	0	0	0	1	0	0	1084	827	29	1	285	1	ATF6	1	161753803	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	616534	161753803	87496818	107	19140										
NOS1AP	9722	broad.mit.edu	37	chr1	162337072	162337072	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccccgcccccagcgcagggcGaggcgctcctgggcggtctg	16	18	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:162337072G>C	uc001gbv.2	+	10	1723	c.1336G>C	c.(1336-1338)GAG>CAG	p.E446Q	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.E441Q|NOS1AP_uc009wut.1_Missense_Mutation_p.E151Q	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	446					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			AGCGCAGGGCGAGGCGCTCCT	0.667													0	0	0	1	0	17	56										C	162337072	G	C	162337072	3	2	65	1	0	0	0	0	1	0	0	0	10542	1059	37	1	1428	1	NOS1AP	1	162337072	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	583269	162337072	86913549	108	19141										
UHMK1	127933	broad.mit.edu	37	chr1	162482610	162482610	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgagaatgaagaggaatatGaaggttagtgttttctaaat	11	1	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:162482610G>A	uc001gcc.1	+	6	1157	c.1021G>A	c.(1021-1023)GAA>AAA	p.E341K	UHMK1_uc001gcb.1_Missense_Mutation_p.E267K|UHMK1_uc009wuu.1_Missense_Mutation_p.E341K	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin	341	RRM.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AGAGGAATATGAAGGTTAGTG	0.328													0	0	0	1	0	35	81										A	162482610	G	A	162482610	3	1	65	1	0	0	0	0	1	0	0	0	16963	1291	45	1	1093	1	UHMK1	1	162482610	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	145538	162482610	86768011	109	19142										
PBX1	5087	broad.mit.edu	37	chr1	164769035	164769035	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgagcggatggtcagcatcAtccaccgcaagttcagctcc	10	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:164769035A>C	uc001gct.2	+	4	868	c.610A>C	c.(610-612)ATC>CTC	p.I204L	PBX1_uc010pku.1_Missense_Mutation_p.I204L|PBX1_uc010pkv.1_Missense_Mutation_p.I121L|PBX1_uc001gcs.2_Missense_Mutation_p.I204L|PBX1_uc010pkw.1_Missense_Mutation_p.I94L	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	204					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						GGTCAGCATCATCCACCGCAA	0.587			T	TCF3|EWSR1	pre B-ALL|myoepithelioma								0	0	0	1	0	15	52										C	164769035	A	C	164769035	3	2	65	1	0	0	0	0	1	0	0	0	11492	217	8	5	624	5	PBX1	1	164769035	Missense_Mutation	SNP	A	TCGA-DK-A3WW-01A-22D-A23M-08	2286425	164769035	84481586	110	19143										
CD247	919	broad.mit.edu	37	chr1	167409970	167409970	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attccatccagcaggtagcaGagtttgggatccagcaggcc	12	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:167409970G>T	uc001gei.3	-	2	238	c.93C>A	c.(91-93)CTC>CTA	p.L31L	CD247_uc001gej.3_Silent_p.L31L|CD247_uc001gek.2_Silent_p.L31L	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	31	Helical; (Potential).				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			GCAGGTAGCAGAGTTTGGGAT	0.547													1	0	1	1	1	8	31										T	167409970	G	T	167409970	2	4	65	1	0	0	0	0	0	0	0	1	2988	929	33	3		3	CD247	1	167409970	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2640935	167409970	81840651	111	19144										
F5	2153	broad.mit.edu	37	chr1	169528466	169528466	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctccagctcttgctttcatCaaacacagcaaatagtagca	6	12	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:169528466C>G	uc001ggg.1	-	5	800	c.655G>C	c.(655-657)GAT>CAT	p.D219H	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	219	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTGCTTTCATCAAACACAGCA	0.453													0	0	0	1	0	20	74										G	169528466	C	G	169528466	3	3	65	1	0	0	0	0	1	0	0	0	5348	826	29	1	6103	1	F5	1	169528466	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2118496	169528466	79722155	112	19145										
C1orf9	51430	broad.mit.edu	37	chr1	172560143	172560143	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtaccgaaaacaaatggaaGaaatgcaaaaggctttcaat	9	6	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:172560143G>C	uc001giq.3	+	19	3161	c.2845G>C	c.(2845-2847)GAA>CAA	p.E949Q	C1orf9_uc010pmm.1_Missense_Mutation_p.E949Q|C1orf9_uc009wwd.2_Missense_Mutation_p.E905Q|C1orf9_uc010pmn.1_Missense_Mutation_p.E578Q|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	949	Potential.				multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		ACAAATGGAAGAAATGCAAAA	0.318													0	0	0	1	0	13	48										C	172560143	G	C	172560143	3	2	65	1	0	0	0	0	1	0	0	0	2067	943	33	1	2919	1	C1orf9	1	172560143	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3031677	172560143	76690478	113	19146										
ASTN1	460	broad.mit.edu	37	chr1	176998854	176998854	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgtgccagaatccccttCagggttcaagaaggcggaac	11	12	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:176998854C>A	uc001glc.2	-	5	1248	c.1036G>T	c.(1036-1038)GAA>TAA	p.E346*	ASTN1_uc001glb.1_Nonsense_Mutation_p.E346*|ASTN1_uc001gld.1_Nonsense_Mutation_p.E346*|ASTN1_uc009wwx.1_Nonsense_Mutation_p.E346*|ASTN1_uc001gle.3_RNA|MIR488_hsa-mir-488|MI0003123_5'Flank	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	346					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GAATCCCCTTCAGGGTTCAAG	0.493													1	0	0.00829132	1	0.00836045	11	19										A	176998854	C	A	176998854	4	1	65	1	0	0	0	0	0	1	0	0	1064	835	29	3	2928	3	ASTN1	1	176998854	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4438711	176998854	72251767	114	19147										
NPHS2	7827	broad.mit.edu	37	chr1	179526245	179526245	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagacgcttcatagtggtttGcacaaggaattgcacagctt	11	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:179526245G>A	uc001gmq.3	-	5	740	c.655C>T	c.(655-657)CAA>TAA	p.Q219*	NPHS2_uc009wxi.2_Intron	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	219	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						ATAGTGGTTTGCACAAGGAAT	0.423													0	0	0	1	0	8	41										A	179526245	G	A	179526245	4	1	65	1	0	0	0	0	0	1	0	0	10583	1328	46	2	512	2	NPHS2	1	179526245	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2527391	179526245	69724376	115	19148										
NPHS2	7827	broad.mit.edu	37	chr1	179526363	179526363	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ataaacatgtctttggtcacGatctaggcagaaaaaagttt	8	6	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:179526363G>A	uc001gmq.3	-	5	622	c.537C>T	c.(535-537)ATC>ATT	p.I179I	NPHS2_uc009wxi.2_Intron	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	179	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						CTTTGGTCACGATCTAGGCAG	0.413													0	0	0	1	0	12	39										A	179526363	G	A	179526363	2	1	65	1	0	0	0	0	0	0	0	1	10583	1048	37	1		1	NPHS2	1	179526363	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	118	179526363	69724258	116	19149										
C1orf26	54823	broad.mit.edu	37	chr1	185143554	185143554	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagaccaaaaatcggttcttCatcccaaagacctattaaac	5	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:185143554C>T	uc001grg.3	+	5	389	c.275C>T	c.(274-276)TCA>TTA	p.S92L	C1orf26_uc001grh.3_Missense_Mutation_p.S92L	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	92											0						ATCGGTTCTTCATCCCAAAGA	0.313													0	0	0	1	0	3	17										T	185143554	C	T	185143554	3	4	65	1	0	0	0	0	1	0	0	0	2035	838	29	1	289	1	C1orf26	1	185143554	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5617191	185143554	64107067	117	19150										
TPR	7175	broad.mit.edu	37	chr1	186320521	186320521	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attttccaacttcttctttaGatgagagatctcatgttcca	5	9	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:186320521G>C	uc001grv.2	-	20	2848	c.2551C>G	c.(2551-2553)CTA>GTA	p.L851V		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	851	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTCTTCTTTAGATGAGAGATC	0.378			T	NTRK1	papillary thyroid								0	0	0	1	0	13	48										C	186320521	G	C	186320521	3	2	65	1	0	0	0	0	1	0	0	0	16413	933	33	1	4668	1	TPR	1	186320521	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1176967	186320521	62930100	118	19151										
ZNF281	23528	broad.mit.edu	37	chr1	200377314	200377314	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtctccacactattatttGatactatgccaagtgagcca	7	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:200377314G>C	uc001gve.2	-	2	1627	c.1520C>G	c.(1519-1521)TCA>TGA	p.S507*	ZNF281_uc001gvf.1_Nonsense_Mutation_p.S507*|ZNF281_uc001gvg.1_Nonsense_Mutation_p.S471*	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	507					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ACTATTATTTGATACTATGCC	0.373													0	0	0	1	0	26	44										C	200377314	G	C	200377314	4	2	65	1	0	0	0	0	0	1	0	0	17815	1294	45	1	1171	1	ZNF281	1	200377314	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	14056793	200377314	48873307	119	19152										
C1orf106	55765	broad.mit.edu	37	chr1	200880791	200880791	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcgccgggcagcagcagcccCgacatctcctttctgcagcc	10	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:200880791C>T	uc001gvo.2	+	9	1455	c.1425C>T	c.(1423-1425)CCC>CCT	p.P475P	C1orf106_uc010ppm.1_Silent_p.P390P	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	475										skin(2)|ovary(1)	3						GCAGCAGCCCCGACATCTCCT	0.692													0	0	0	1	0	76	180										T	200880791	C	T	200880791	2	4	65	1	0	0	0	0	0	0	0	1	1980	639	23	2		2	C1orf106	1	200880791	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	503477	200880791	48369830	120	19153										
CACNA1S	779	broad.mit.edu	37	chr1	201017798	201017798	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcgctgttcaggggcatgttCatgcccaccagccgctgtac	11	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:201017798C>T	uc001gvv.2	-	36	4580	c.4353G>A	c.(4351-4353)ATG>ATA	p.M1451I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1451	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGGGCATGTTCATGCCCACCA	0.617													0	0	0	1	0	10	34										T	201017798	C	T	201017798	3	4	65	1	0	0	0	0	1	0	0	0	2547	826	29	1	1304	1	CACNA1S	1	201017798	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	137007	201017798	48232823	121	19154										
CACNA1S	779	broad.mit.edu	37	chr1	201019552	201019552	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tactctgcccagatggccttGaactcatccaggtgatgagg	11	11	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:201019552G>C	uc001gvv.2	-	34	4433	c.4206C>G	c.(4204-4206)TTC>TTG	p.F1402L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1402	Dihydropyridine binding (By similarity).|Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AGATGGCCTTGAACTCATCCA	0.547													0	0	0	1	0	25	52										C	201019552	G	C	201019552	3	2	65	1	0	0	0	0	1	0	0	0	2547	1281	45	1	1459	1	CACNA1S	1	201019552	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1754	201019552	48231069	122	19155										
CACNA1S	779	broad.mit.edu	37	chr1	201079390	201079390	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgagcaagatgatcgtctCgaagggcctggagccagggt	17	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:201079390C>G	uc001gvv.2	-	2	387	c.160G>C	c.(160-162)GAG>CAG	p.E54Q		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	54	I.|Helical; Name=S1 of repeat I; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGATCGTCTCGAAGGGCCTG	0.577													0	0	0	1	0	26	70										G	201079390	C	G	201079390	3	3	65	1	0	0	0	0	1	0	0	0	2547	893	31	1	5633	1	CACNA1S	1	201079390	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	59838	201079390	48171231	123	19156										
GPR37L1	9283	broad.mit.edu	37	chr1	202092471	202092471	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtatccggtgaccgagagctCctacagtgcctatgccatca	10	13	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:202092471C>G	uc001gxj.2	+	1	443	c.380C>G	c.(379-381)TCC>TGC	p.S127C		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	127	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						ACCGAGAGCTCCTACAGTGCC	0.597													0	0	0	1	0	22	67										G	202092471	C	G	202092471	3	3	65	1	0	0	0	0	1	0	0	0	6692	855	30	1	382	1	GPR37L1	1	202092471	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1013081	202092471	47158150	124	19157										
BTG2	7832	broad.mit.edu	37	chr1	203274737	203274737	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcccgagccgcgcgcgacatGagccacgggaagggaaccga	16	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:203274737G>A	uc001gzq.2	+	1	74	c.3G>A	c.(1-3)ATG>ATA	p.M1I	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	1					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.M1I(1)		ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			CGCGCGACATGAGCCACGGGA	0.697													0	0	0	1	0	3	10										A	203274737	G	A	203274737	3	1	65	1	0	0	0	0	1	0	0	0	1554	1290	45	1	5	1	BTG2	1	203274737	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1182266	203274737	45975884	125	19158										
ATP2B4	493	broad.mit.edu	37	chr1	203667470	203667470	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttttatcgccctgctggtGaagaaaatgaacgtgagtgt	11	8	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:203667470G>A	uc001gzw.2	+	3	1263	c.379G>A	c.(379-381)GAA>AAA	p.E127K	ATP2B4_uc001gzv.2_Missense_Mutation_p.E127K|ATP2B4_uc009xaq.2_Missense_Mutation_p.E127K	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	127	Extracellular (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCCTGCTGGTGAAGAAAATGA	0.488													0	0	0	1	0	27	76										A	203667470	G	A	203667470	3	1	65	1	0	0	0	0	1	0	0	0	1142	1291	45	1	385	1	ATP2B4	1	203667470	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	392733	203667470	45583151	126	19159										
NUAK2	81788	broad.mit.edu	37	chr1	205280856	205280856	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catggatggcaatgatgtgaGggtggttgagtgatgacatg	17	3	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:205280856G>A	uc001hce.2	-	2	456	c.329C>T	c.(328-330)CCT>CTT	p.P110L	NUAK2_uc009xbj.1_5'Flank	NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	110	Protein kinase.				actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			AATGATGTGAGGGTGGTTGAG	0.473													0	0	0	1	0	12	49										A	205280856	G	A	205280856	3	1	65	1	0	0	0	0	1	0	0	0	10713	1000	35	2	1581	2	NUAK2	1	205280856	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1613386	205280856	43969765	127	19160										
MAPKAPK2	9261	broad.mit.edu	37	chr1	206904055	206904055	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagaagtgctgggtccagaGaagtatgacaagtcctgtga	13	8	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:206904055G>A	uc001hem.1	+	6	1000	c.714G>A	c.(712-714)GAG>GAA	p.E238E	MAPKAPK2_uc001hel.1_Silent_p.E238E	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated	238	Protein kinase.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			TGGGTCCAGAGAAGTATGACA	0.572													0	0	0	1	0	30	80										A	206904055	G	A	206904055	2	1	65	1	0	0	0	0	0	0	0	1	9289	933	33	1		1	MAPKAPK2	1	206904055	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1623199	206904055	42346566	128	19161										
IL10	3586	broad.mit.edu	37	chr1	206944333	206944333	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgatgtctgggtcttggttCtcagcttggggcatcacctc	12	10	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:206944333C>T	uc001hen.1	-	3	356	c.297G>A	c.(295-297)GAG>GAA	p.E99E		NM_000572	NP_000563	P22301	IL10_HUMAN	interleukin 10 precursor	99					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			GGTCTTGGTTCTCAGCTTGGG	0.547													0	0	0	1	0	39	110										T	206944333	C	T	206944333	2	4	65	1	0	0	0	0	0	0	0	1	7619	912	32	1		1	IL10	1	206944333	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	40278	206944333	42306288	129	19162										
CR2	1380	broad.mit.edu	37	chr1	207651346	207651346	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgaagatgggtatatgctgGaaggcagtccccagagccag	15	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:207651346G>T	uc001hfw.2	+	15	2936	c.2842G>T	c.(2842-2844)GAA>TAA	p.E948*	CR2_uc001hfv.2_Nonsense_Mutation_p.E1007*|CR2_uc009xch.2_Nonsense_Mutation_p.E886*	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	948	Sushi 15.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GTATATGCTGGAAGGCAGTCC	0.522													1	0	9.70103e-10	1	1.01257e-09	11	39										T	207651346	G	T	207651346	4	4	65	1	0	0	0	0	0	1	0	0	3842	1175	41	3	3081	3	CR2	1	207651346	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	707013	207651346	41599275	130	19163										
CR2	1380	broad.mit.edu	37	chr1	207651410	207651410	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccctcccctggcggtttgcaGatcccgtaagtaccaagggc	11	15	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:207651410G>T	uc001hfw.2	+	15	3000	c.2906G>T	c.(2905-2907)AGA>ATA	p.R969I	CR2_uc001hfv.2_Missense_Mutation_p.R1028I|CR2_uc009xch.2_Missense_Mutation_p.R907I	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	969	Sushi 15.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GCGGTTTGCAGATCCCGTAAG	0.532													1	0	0.000157383	1	0.000159646	5	31										T	207651410	G	T	207651410	3	4	65	1	0	0	0	0	1	0	0	0	3842	942	33	3	3145	3	CR2	1	207651410	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	64	207651410	41599211	131	19164										
CD34	947	broad.mit.edu	37	chr1	208062850	208062850	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcagtagacactgaggcctCacctcagactgggcaaggag	13	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:208062850C>T	uc001hgw.1	-	5	972	c.714G>A	c.(712-714)GTG>GTA	p.V238V	CD34_uc001hgv.1_Silent_p.V80V|CD34_uc001hgx.1_Silent_p.V238V|CD34_uc010psj.1_Silent_p.V103V	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	238	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						ACTGAGGCCTCACCTCAGACT	0.612													0	0	0	1	0	11	37										T	208062850	C	T	208062850	2	4	65	1	0	0	0	0	0	0	0	1	3006	813	29	1		1	CD34	1	208062850	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	411440	208062850	41187771	132	19165										
LAMB3	3914	broad.mit.edu	37	chr1	209805953	209805953	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcggtggaggggcctgcaGaggccccaggcttgggtgcg	20	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:209805953G>A	uc001hhg.2	-	7	1187	c.797C>T	c.(796-798)TCT>TTT	p.S266F	LAMB3_uc009xco.2_Missense_Mutation_p.S266F|LAMB3_uc001hhh.2_Missense_Mutation_p.S266F|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Missense_Mutation_p.S202F	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	266	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGGGCCTGCAGAGGCCCCAGG	0.652													0	0	0	1	0	24	53										A	209805953	G	A	209805953	3	1	65	1	0	0	0	0	1	0	0	0	8612	942	33	1	2785	1	LAMB3	1	209805953	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1743103	209805953	39444668	133	19166										
SYT14	255928	broad.mit.edu	37	chr1	210273593	210273593	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agagcaaaaaccagcatccaGagaggaccatgccctgtctt	9	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:210273593G>C	uc009xcv.2	+	6	1023	c.951G>C	c.(949-951)CAG>CAC	p.Q317H	SYT14_uc001hhs.3_Missense_Mutation_p.Q362H|SYT14_uc001hht.3_Missense_Mutation_p.Q317H|SYT14_uc001hhu.3_Intron|SYT14_uc010psn.1_Missense_Mutation_p.Q362H|SYT14_uc010pso.1_Missense_Mutation_p.Q279H	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	317	Cytoplasmic (Potential).|C2 1.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		CCAGCATCCAGAGAGGACCAT	0.403													0	0	0	1	0	14	38										C	210273593	G	C	210273593	3	2	65	1	0	0	0	0	1	0	0	0	15467	933	33	1	1112	1	SYT14	1	210273593	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	467640	210273593	38977028	134	19167										
INTS7	25896	broad.mit.edu	37	chr1	212180677	212180677	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccattttggtggacggatagGatgtgaccagctgttgtaaa	13	6	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:212180677G>C	uc001hiw.1	-	6	776	c.671C>G	c.(670-672)TCC>TGC	p.S224C	INTS7_uc009xdb.1_Missense_Mutation_p.S224C|INTS7_uc001hix.1_Missense_Mutation_p.S100C|INTS7_uc001hiy.1_Missense_Mutation_p.S224C|INTS7_uc010pta.1_Missense_Mutation_p.S175C	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	224					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GGACGGATAGGATGTGACCAG	0.433													0	0	0	1	0	14	45										C	212180677	G	C	212180677	3	2	65	1	0	0	0	0	1	0	0	0	7783	1174	41	1	2277	1	INTS7	1	212180677	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1907084	212180677	37069944	135	19168										
DTL	51514	broad.mit.edu	37	chr1	212274365	212274365	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggctgagaatccatctccacGaagtccgtcatcccagacac	8	15	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:212274365G>A	uc009xdc.2	+	14	2347	c.2033G>A	c.(2032-2034)CGA>CAA	p.R678Q	DTL_uc010ptb.1_Missense_Mutation_p.R636Q|DTL_uc001hiz.3_Missense_Mutation_p.R407Q	NM_016448	NP_057532	Q9NZJ0	DTL_HUMAN	denticleless homolog	678					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		CCATCTCCACGAAGTCCGTCA	0.488													0	0	0	1	0	13	53										A	212274365	G	A	212274365	3	1	65	1	0	0	0	0	1	0	0	0	4787	1058	37	1	2087	1	DTL	1	212274365	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	93688	212274365	36976256	136	19169										
RPS6KC1	26750	broad.mit.edu	37	chr1	213414278	213414278	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcaagatgacagcaaccagGaagatgatggccaagatagc	11	9	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:213414278G>A	uc010ptr.1	+	11	1618	c.1459G>A	c.(1459-1461)GAA>AAA	p.E487K	RPS6KC1_uc001hkd.2_Missense_Mutation_p.E475K|RPS6KC1_uc010pts.1_Missense_Mutation_p.E275K|RPS6KC1_uc010ptt.1_Missense_Mutation_p.E275K|RPS6KC1_uc010ptu.1_Missense_Mutation_p.E306K|RPS6KC1_uc010ptv.1_Missense_Mutation_p.E22K|RPS6KC1_uc001hke.2_Missense_Mutation_p.E306K	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	487					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CAGCAACCAGGAAGATGATGG	0.413													0	0	0	1	0	20	71										A	213414278	G	A	213414278	3	1	65	1	0	0	0	0	1	0	0	0	13658	1175	41	1	1501	1	RPS6KC1	1	213414278	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1139913	213414278	35836343	137	19170										
GPATCH2	55105	broad.mit.edu	37	chr1	217784238	217784238	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagtgctactgacctcttctGcttgggtgtgacataagggg	13	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:217784238G>A	uc001hlf.1	-	4	1107	c.1011C>T	c.(1009-1011)AGC>AGT	p.S337S	GPATCH2_uc001hlg.3_Silent_p.S337S	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	337						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		GACCTCTTCTGCTTGGGTGTG	0.413													0	0	0	1	0	14	41										A	217784238	G	A	217784238	2	1	65	1	0	0	0	0	0	0	0	1	6591	1310	46	2		2	GPATCH2	1	217784238	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4369960	217784238	31466383	138	19171										
SLC30A10	55532	broad.mit.edu	37	chr1	220101335	220101335	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgccgctgctgcaggcggcGactgcgtccccggaggcagc	16	16	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:220101335G>A	uc001hlw.2	-	1	659	c.448C>T	c.(448-450)CGC>TGC	p.R150C	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlx.2_5'UTR	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	150	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		TGCAGGCGGCGACTGCGTCCC	0.746													0	0	0	1	0	4	5										A	220101335	G	A	220101335	3	1	65	1	0	0	0	0	1	0	0	0	14554	1058	37	1	1025	1	SLC30A10	1	220101335	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2317097	220101335	29149286	139	19172										
MARK1	4139	broad.mit.edu	37	chr1	220752866	220752866	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagggaaattttgccaaagtCaaattggcaagacacgttct	9	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:220752866C>T	uc001hmn.3	+	2	819	c.222C>T	c.(220-222)GTC>GTT	p.V74V	MARK1_uc001hml.2_Silent_p.V74V|MARK1_uc009xdw.2_Silent_p.V74V|MARK1_uc010pun.1_Silent_p.V74V|MARK1_uc001hmm.3_Silent_p.V74V	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	74	ATP (By similarity).|Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TTGCCAAAGTCAAATTGGCAA	0.413													0	0	0	1	0	9	58										T	220752866	C	T	220752866	2	4	65	1	0	0	0	0	0	0	0	1	9312	813	29	1		1	MARK1	1	220752866	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	651531	220752866	28497755	140	19173										
DISP1	84976	broad.mit.edu	37	chr1	223163986	223163986	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gttatgcagccctgatagccGactggccggtggtggtcttg	15	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:223163986G>A	uc001hnu.1	+	4	706	c.559G>A	c.(559-561)GAC>AAC	p.D187N		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	187					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		CCTGATAGCCGACTGGCCGGT	0.498													0	0	0	1	0	40	110										A	223163986	G	A	223163986	3	1	65	1	0	0	0	0	1	0	0	0	4539	1058	37	1	569	1	DISP1	1	223163986	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2411120	223163986	26086635	141	19174										
SUSD4	55061	broad.mit.edu	37	chr1	223536710	223536710	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggggactgaggttgctgctGctgctgctgctgctctagaa	16	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:223536710G>A	uc001hnx.2	-	1	692	c.58C>T	c.(58-60)CAG>TAG	p.Q20*	SUSD4_uc001hny.3_Nonsense_Mutation_p.Q20*|SUSD4_uc010puw.1_5'UTR|SUSD4_uc001hnz.2_Nonsense_Mutation_p.Q20*|SUSD4_uc010pux.1_Nonsense_Mutation_p.Q20*	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	20						integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		GGTtgctgctgctgctgctgc	0.502													0	0	0	1	0	4	17										A	223536710	G	A	223536710	4	1	65	1	0	0	0	0	0	1	0	0	15407	1328	46	2	1599	2	SUSD4	1	223536710	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	372724	223536710	25713911	142	19175										
FBXO28	23219	broad.mit.edu	37	chr1	224345239	224345239	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaaaacagcttcaagaccagGaccagaaactgctagagcag	9	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:224345239G>C	uc001hoh.2	+	5	939	c.898G>C	c.(898-900)GAC>CAC	p.D300H	FBXO28_uc009xef.2_3'UTR|FBXO28_uc010pvc.1_Missense_Mutation_p.D95H	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	300										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		TCAAGACCAGGACCAGAAACT	0.473													0	0	0	1	0	32	158										C	224345239	G	C	224345239	3	2	65	1	0	0	0	0	1	0	0	0	5738	1174	41	1	916	1	FBXO28	1	224345239	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	808529	224345239	24905382	143	19176										
FBXO28	23219	broad.mit.edu	37	chr1	224345339	224345339	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtaatggaaagtgctgtagGaaattcctcagggtccgggc	14	7	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:224345339G>C	uc001hoh.2	+	5	1039	c.998G>C	c.(997-999)GGA>GCA	p.G333A	FBXO28_uc009xef.2_3'UTR|FBXO28_uc010pvc.1_Missense_Mutation_p.G128A	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	333										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		AGTGCTGTAGGAAATTCCTCA	0.478													0	0	0	1	0	28	113										C	224345339	G	C	224345339	3	2	65	1	0	0	0	0	1	0	0	0	5738	1174	41	1	1016	1	FBXO28	1	224345339	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	100	224345339	24905282	144	19177										
CDC42BPA	8476	broad.mit.edu	37	chr1	227204633	227204633	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggttaagtatctacctcctCtgctgcatcctttcctcttc	5	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:227204633C>G	uc001hqr.2	-	32	5572	c.4629G>C	c.(4627-4629)CAG>CAC	p.Q1543H	CDC42BPA_uc001hqq.2_Missense_Mutation_p.Q842H|CDC42BPA_uc001hqs.2_Missense_Mutation_p.Q1462H|CDC42BPA_uc009xes.2_Missense_Mutation_p.Q1515H|CDC42BPA_uc010pvs.1_Missense_Mutation_p.Q1523H|CDC42BPA_uc001hqp.2_Missense_Mutation_p.Q699H|CDC42BPA_uc001hqt.2_Missense_Mutation_p.Q421H	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1556					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TCTACCTCCTCTGCTGCATCC	0.398													0	0	0	1	0	15	48										G	227204633	C	G	227204633	3	3	65	1	0	0	0	0	1	0	0	0	3072	912	32	1	550	1	CDC42BPA	1	227204633	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2859294	227204633	22045988	145	19178										
OBSCN	84033	broad.mit.edu	37	chr1	228475825	228475825	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacagaaggggccacggccaCgctgcggtgtgagctgagca	16	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:228475825C>T	uc009xez.1	+	37	9919	c.9875C>T	c.(9874-9876)ACG>ATG	p.T3292M	OBSCN_uc001hsn.2_Missense_Mutation_p.T3292M|OBSCN_uc001hsq.1_Missense_Mutation_p.T548M	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3292	Ig-like 33.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCACGGCCACGCTGCGGTGT	0.612													0	0	0	1	0	51	112										T	228475825	C	T	228475825	3	4	65	1	0	0	0	0	1	0	0	0	10812	536	19	2	10017	2	OBSCN	1	228475825	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1271192	228475825	20774796	146	19179										
ACTA1	58	broad.mit.edu	37	chr1	229567842	229567842	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgtagctcttttccagggagGaggaggaggcggccgtcgcc	17	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:229567842G>T	uc001htm.2	-	5	812	c.707C>A	c.(706-708)TCC>TAC	p.S236Y		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	236					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	TTCCAGGGAGGAGGAGGAGGC	0.642													1	0	1.3612e-06	1	1.40263e-06	14	42										T	229567842	G	T	229567842	3	4	65	1	0	0	0	0	1	0	0	0	191	1174	41	3	438	3	ACTA1	1	229567842	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1092017	229567842	19682779	147	19180										
URB2	9816	broad.mit.edu	37	chr1	229779297	229779297	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagatcctgaaattcctgttCaggtcactcaggatattgag	9	9	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:229779297C>T	uc001hts.1	+	5	3788	c.3652C>T	c.(3652-3654)CAG>TAG	p.Q1218*	URB2_uc009xfd.1_Nonsense_Mutation_p.Q1218*	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1218						nucleolus				central_nervous_system(2)|ovary(1)	3						AATTCCTGTTCAGGTCACTCA	0.448													0	0	0	1	0	19	72										T	229779297	C	T	229779297	4	4	65	1	0	0	0	0	0	1	0	0	17022	827	29	1	3666	1	URB2	1	229779297	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	211455	229779297	19471324	148	19181										
GALNT2	2590	broad.mit.edu	37	chr1	230314024	230314024	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcatcacagcaatggagaaGagaaagcacaaagcatggag	11	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:230314024G>C	uc010pwa.1	+	2	259	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	GALNT2_uc010pvy.1_Missense_Mutation_p.E25Q|GALNT2_uc010pvz.1_Intron	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	63	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				CAATGGAGAAGAGAAAGCACA	0.493													0	0	0	1	0	9	53										C	230314024	G	C	230314024	3	2	65	1	0	0	0	0	1	0	0	0	6213	943	33	1	193	1	GALNT2	1	230314024	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	534727	230314024	18936597	149	19182										
PCNXL2	80003	broad.mit.edu	37	chr1	233344284	233344284	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctattaagtagtccctagctGattgtagaaacactggagag	10	7	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:233344284G>A	uc001hvl.2	-	13	3078	c.2843C>T	c.(2842-2844)TCA>TTA	p.S948L	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_Missense_Mutation_p.S247L	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	948						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GTCCCTAGCTGATTGTAGAAA	0.468													0	0	0	1	0	15	41										A	233344284	G	A	233344284	3	1	65	1	0	0	0	0	1	0	0	0	11592	1294	45	1	3658	1	PCNXL2	1	233344284	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3030260	233344284	15906337	150	19183										
TOMM20	9804	broad.mit.edu	37	chr1	235277211	235277211	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atttgtcagatggtctacgcCcttctcatattcacctgtaa	6	11	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:235277211C>T	uc001hwl.2	-	4	491	c.265G>A	c.(265-267)GGC>AGC	p.G89S	TOMM20_uc009xfx.1_Intron	NM_014765	NP_055580	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20	89	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding				0	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)			TGGTCTACGCCCTTCTCATAT	0.418													0	0	0	1	0	24	55										T	235277211	C	T	235277211	3	4	65	1	0	0	0	0	1	0	0	0	16351	623	22	2	180	2	TOMM20	1	235277211	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1932927	235277211	13973410	151	19184										
RYR2	6262	broad.mit.edu	37	chr1	237619914	237619914	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttccagggaatgatcaacctCgtgcttgagtgcatagaccg	11	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:237619914C>T	uc001hyl.1	+	16	1611	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	497	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGATCAACCTCGTGCTTGAGT	0.413													0	0	0	1	0	12	57										T	237619914	C	T	237619914	2	4	65	1	0	0	0	0	0	0	0	1	13769	871	31	1		1	RYR2	1	237619914	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2342703	237619914	11630707	152	19185										
RYR2	6262	broad.mit.edu	37	chr1	237872347	237872347	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgagttcaccacactggccaGagatctctatgccttctacc	7	14	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:237872347G>A	uc001hyl.1	+	69	10211	c.10091G>A	c.(10090-10092)AGA>AAA	p.R3364K	RYR2_uc010pxz.1_Missense_Mutation_p.R319K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3364					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACACTGGCCAGAGATCTCTAT	0.463													0	0	0	1	0	10	22										A	237872347	G	A	237872347	3	1	65	1	0	0	0	0	1	0	0	0	13769	942	33	1	10365	1	RYR2	1	237872347	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	252433	237872347	11378274	153	19186										
SDCCAG8	10806	broad.mit.edu	37	chr1	243433447	243433447	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caccaactgacatgtgccctGaaagaaggcgatgtcactat	9	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:243433447G>A	uc001hzw.2	+	2	264	c.108G>A	c.(106-108)CTG>CTA	p.L36L	SDCCAG8_uc010pyk.1_Intron|SDCCAG8_uc010pyl.1_Intron	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	36					establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		CATGTGCCCTGAAAGAAGGCG	0.493													0	0	0	1	0	8	35										A	243433447	G	A	243433447	2	1	65	1	0	0	0	0	0	0	0	1	13959	1277	45	1		1	SDCCAG8	1	243433447	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5561100	243433447	5817174	154	19187										
AKT3	10000	broad.mit.edu	37	chr1	243727132	243727132	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttatgtggccatctttgtCcagcattagattctccaact	6	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:243727132C>G	uc001iab.1	-	9	919	c.838G>C	c.(838-840)GAC>CAC	p.D280H	AKT3_uc001hzz.1_Missense_Mutation_p.D280H	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	280	Protein kinase.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			CCATCTTTGTCCAGCATTAGA	0.348													0	0	0	1	0	16	51										G	243727132	C	G	243727132	3	3	65	1	0	0	0	0	1	0	0	0	481	855	30	1	669	1	AKT3	1	243727132	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	293685	243727132	5523489	155	19188										
KIF26B	55083	broad.mit.edu	37	chr1	245765916	245765916	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catctgttccaccttggctcGagatacttcagaatccagct	7	13	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:245765916G>C	uc001ibf.1	+	6	1828	c.1388G>C	c.(1387-1389)CGA>CCA	p.R463P	KIF26B_uc010pyq.1_Missense_Mutation_p.R463P|KIF26B_uc001ibg.1_Missense_Mutation_p.R81P	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	463	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			ACCTTGGCTCGAGATACTTCA	0.488													0	0	0	1	0	10	25										C	245765916	G	C	245765916	3	2	65	1	0	0	0	0	1	0	0	0	8295	1058	37	1	1410	1	KIF26B	1	245765916	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2038784	245765916	3484705	156	19189										
OR2T8	343172	broad.mit.edu	37	chr1	248085113	248085113	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagacccaaatcccacaggtCcactaaccacgacaaggttg	8	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:248085113C>G	uc010pzc.1	+	1	794	c.794C>G	c.(793-795)TCC>TGC	p.S265C		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCCCACAGGTCCACTAACCAC	0.493													0	0	0	1	0	22	64										G	248085113	C	G	248085113	3	3	65	1	0	0	0	0	1	0	0	0	11030	855	30	1	796	1	OR2T8	1	248085113	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2319197	248085113	1165508	157	19190										
SH3BP5L	80851	broad.mit.edu	37	chr1	249106497	249106497	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgatctgctccaggttacGaagggccacggagtagcgcg	15	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr1:249106497G>A	uc001iew.1	-	7	1336	c.784C>T	c.(784-786)CGT>TGT	p.R262C	SH3BP5L_uc010pzp.1_Missense_Mutation_p.R155C|SH3BP5L_uc010pzq.1_Missense_Mutation_p.R230C|SH3BP5L_uc001iev.1_Missense_Mutation_p.R143C	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	262	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			TCCAGGTTACGAAGGGCCACG	0.682													0	0	0	1	0	15	55										A	249106497	G	A	249106497	3	1	65	1	0	0	0	0	1	0	0	0	14248	1058	37	1	401	1	SH3BP5L	1	249106497	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1021384	249106497	144124	158	19191										
MYT1L	23040	broad.mit.edu	37	chr2	1795702	1795702	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggctttattttctggactCtgataacgatcttgatttgt	9	6	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:1795702C>G	uc002qxe.2	-	25	4325	c.3498G>C	c.(3496-3498)CAG>CAC	p.Q1166H	MYT1L_uc002qxd.2_Missense_Mutation_p.Q1164H|MYT1L_uc010ewk.2_Missense_Mutation_p.Q164H	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1166					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TTTCTGGACTCTGATAACGAT	0.363													0	0	0	1	0	11	30										G	1795702	C	G	1795702	3	3	65	1	0	0	0	0	1	0	0	0	10107	912	32	1	66	1	MYT1L	2	1795702	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		1795702	241403671	159	19192										
TTC15	51112	broad.mit.edu	37	chr2	3481522	3481522	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacgttgagaaagtaacacaGaaattagatggactacaggg	12	5	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:3481522G>C	uc002qxm.1	+	10	2039	c.1833G>C	c.(1831-1833)CAG>CAC	p.Q611H	TTC15_uc002qxn.1_Missense_Mutation_p.Q611H|TTC15_uc010ewm.1_Missense_Mutation_p.Q617H	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	611	TPR 2.						binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		AAGTAACACAGAAATTAGATG	0.308													0	0	0	1	0	7	35										C	3481522	G	C	3481522	3	2	65	1	0	0	0	0	1	0	0	0	16679	933	33	1	1867	1	TTC15	2	3481522	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1685820	3481522	239717851	160	19193										
ITGB1BP1	9270	broad.mit.edu	37	chr2	9546976	9546976	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaggattcagggtttctcaGatgttaatacagagtcaaaa	10	6	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:9546976G>T	uc002qzj.2	-	7	767	c.590C>A	c.(589-591)TCT>TAT	p.S197Y	ITGB1BP1_uc002qzk.2_Missense_Mutation_p.S147Y|ITGB1BP1_uc002qzl.2_RNA|ITGB1BP1_uc002qzm.2_RNA|ITGB1BP1_uc010yiy.1_Missense_Mutation_p.S153Y|ITGB1BP1_uc002qzn.1_3'UTR	NM_004763	NP_004754	O14713	ITBP1_HUMAN	integrin cytoplasmic domain-associated protein 1	197	PID.				cell migration|cell-matrix adhesion|intracellular protein kinase cascade	cytosol|lamellipodium|membrane|ruffle	protein binding|protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.23)		GGGTTTCTCAGATGTTAATAC	0.368													1	0	5.3912e-06	1	5.52835e-06	18	46										T	9546976	G	T	9546976	3	4	65	1	0	0	0	0	1	0	0	0	7891	942	33	3	16	3	ITGB1BP1	2	9546976	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6065454	9546976	233652397	161	19194										
E2F6	1876	broad.mit.edu	37	chr2	11586617	11586617	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgccatcagttgcttacttCaagcaattcttcactttgct	5	11	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:11586617C>A	uc002rbh.2	-	7	1124	c.832G>T	c.(832-834)GAA>TAA	p.E278*	E2F6_uc002rbe.2_Nonsense_Mutation_p.E203*|E2F6_uc002rbf.2_Nonsense_Mutation_p.E246*|E2F6_uc002rbg.2_Nonsense_Mutation_p.E203*|E2F6_uc002rbi.2_Nonsense_Mutation_p.E203*|E2F6_uc010yjl.1_RNA	NM_198256	NP_937987	O75461	E2F6_HUMAN	E2F transcription factor 6	278	Transcription repression.				negative regulation of transcription from RNA polymerase II promoter	MLL1 complex|transcription factor complex	DNA binding|transcription corepressor activity			skin(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.114)|OV - Ovarian serous cystadenocarcinoma(76;0.168)		TTGCTTACTTCAAGCAATTCT	0.363													1	0	0.0931896	1	0.093521	12	34										A	11586617	C	A	11586617	4	1	65	1	0	0	0	0	0	1	0	0	4871	835	29	3	17	3	E2F6	2	11586617	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2039641	11586617	231612756	162	19195										
MFSD2B	388931	broad.mit.edu	37	chr2	24239769	24239769	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacttcttcctgtggttcctGccccccttcaccagcctgcg	7	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:24239769G>A	uc002reo.1	+	4	416	c.402G>A	c.(400-402)CTG>CTA	p.L134L	MFSD2B_uc010exz.1_RNA	NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	134					transport	integral to membrane				ovary(2)	2						TGTGGTTCCTGCCCCCCTTCA	0.672													0	0	0	1	0	20	78										A	24239769	G	A	24239769	2	1	65	1	0	0	0	0	0	0	0	1	9531	1306	46	2		2	MFSD2B	2	24239769	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	12653152	24239769	218959604	163	19196										
ITSN2	50618	broad.mit.edu	37	chr2	24524067	24524067	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttcttgcattttctgatatGaaggcagagttccattaatg	8	7	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:24524067G>A	uc002rfe.2	-	11	1295	c.1037C>T	c.(1036-1038)TCA>TTA	p.S346L	ITSN2_uc002rff.2_Missense_Mutation_p.S346L|ITSN2_uc002rfg.2_Missense_Mutation_p.S346L|ITSN2_uc010eyd.2_Missense_Mutation_p.S371L	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	346					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTCTGATATGAAGGCAGAGT	0.338													0	0	0	1	0	17	35										A	24524067	G	A	24524067	3	1	65	1	0	0	0	0	1	0	0	0	7927	1294	45	1	4227	1	ITSN2	2	24524067	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	284298	24524067	218675306	164	19197										
NCOA1	8648	broad.mit.edu	37	chr2	24929894	24929894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttcgacattaagctctcccGttggcatgacaagtagtgcc	9	11	1	1	rs144856306		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:24929894G>A	uc002rfk.2	+	11	1813	c.1555G>A	c.(1555-1557)GTT>ATT	p.V519I	NCOA1_uc010eye.2_Missense_Mutation_p.V519I|NCOA1_uc002rfi.2_Missense_Mutation_p.V368I|NCOA1_uc002rfj.2_Missense_Mutation_p.V519I|NCOA1_uc002rfl.2_Missense_Mutation_p.V519I	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	519	Interaction with STAT3.|Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGCTCTCCCGTTGGCATGAC	0.423			T	PAX3	alveolar rhadomyosarcoma								0	0	0	1	0	22	68										A	24929894	G	A	24929894	3	1	65	1	0	0	0	0	1	0	0	0	10228	1145	40	2	1589	2	NCOA1	2	24929894	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	405827	24929894	218269479	165	19198										
DNMT3A	1788	broad.mit.edu	37	chr2	25457247	25457247	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgcctcgccaagcggctCatgttggagacgtcagtata	11	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:25457247C>T	uc002rgc.2	-	23	2897	c.2640G>A	c.(2638-2640)ATG>ATA	p.M880I	DNMT3A_uc002rgd.2_Missense_Mutation_p.M880I|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.M691I	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	880					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAAGCGGCTCATGTTGGAGA	0.597			Mis|F|N|S		AML								0	0	0	1	0	28	58										T	25457247	C	T	25457247	3	4	65	1	0	0	0	0	1	0	0	0	4676	826	29	1	102	1	DNMT3A	2	25457247	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	527353	25457247	217742126	166	19199										
IFT172	26160	broad.mit.edu	37	chr2	27676285	27676285	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctccgccaggccgctgtttCcagagtctcgcactttgagg	11	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:27676285C>G	uc002rku.2	-	35	3968	c.3917G>C	c.(3916-3918)GGA>GCA	p.G1306A	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1306	TPR 10.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GCCGCTGTTTCCAGAGTCTCG	0.587													0	0	0	1	0	19	89										G	27676285	C	G	27676285	3	3	65	1	0	0	0	0	1	0	0	0	7557	855	30	1	1388	1	IFT172	2	27676285	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2219038	27676285	215523088	167	19200										
IFT172	26160	broad.mit.edu	37	chr2	27700949	27700949	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgttcctttcctaggattttCacctcttccacctcatagcc	4	16	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:27700949C>T	uc002rku.2	-	11	1131	c.1080G>A	c.(1078-1080)GTG>GTA	p.V360V	IFT172_uc002rkw.2_Silent_p.V360V|IFT172_uc010yls.1_Silent_p.V339V|IFT172_uc010ezc.2_Silent_p.V360V|IFT172_uc002rkv.2_Silent_p.V334V	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	360					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					CTAGGATTTTCACCTCTTCCA	0.493													0	0	0	1	0	55	147										T	27700949	C	T	27700949	2	4	65	1	0	0	0	0	0	0	0	1	7557	813	29	1		1	IFT172	2	27700949	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	24664	27700949	215498424	168	19201										
BIRC6	57448	broad.mit.edu	37	chr2	32620589	32620589	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aattttgcagcctgcctcatCtggagatgatagagccatgt	10	9	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:32620589C>G	uc010ezu.2	+	6	1096	c.962C>G	c.(961-963)TCT>TGT	p.S321C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	321	BIR.				anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CCTGCCTCATCTGGAGATGAT	0.323													0	0	0	1	0	35	83										G	32620589	C	G	32620589	3	3	65	1	0	0	0	0	1	0	0	0	1438	913	32	1	984	1	BIRC6	2	32620589	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4919640	32620589	210578784	169	19202										
BIRC6	57448	broad.mit.edu	37	chr2	32678953	32678953	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacttttggaagttgaacctCtgcactttacttgtgtgtca	9	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:32678953C>G	uc010ezu.2	+	23	4830	c.4696C>G	c.(4696-4698)CTG>GTG	p.L1566V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1566					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGTTGAACCTCTGCACTTTAC	0.383													0	0	0	1	0	24	59										G	32678953	C	G	32678953	3	3	65	1	0	0	0	0	1	0	0	0	1438	912	32	1	4786	1	BIRC6	2	32678953	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	58364	32678953	210520420	170	19203										
STRN	6801	broad.mit.edu	37	chr2	37113903	37113903	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctcctttttgtattgttccTtgagtttggtaattactccc	6	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:37113903T>A	uc002rpn.2	-	8	1007	c.998A>T	c.(997-999)AAG>ATG	p.K333M	STRN_uc010ezx.2_Intron	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	333					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GTATTGTTCCTTGAGTTTGGT	0.403													0	0	0	1	0	20	76										A	37113903	T	A	37113903	3	1	65	1	0	0	0	0	1	0	0	0	15328	1609	56	5	1388	5	STRN	2	37113903	Missense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	4434950	37113903	206085470	171	19204										
CEBPZ	10153	broad.mit.edu	37	chr2	37458641	37458641	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcatcctcctcgtccggatCttctactgcctcctcggggc	8	18	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:37458641C>G	uc002rpz.2	-	1	100	c.70G>C	c.(70-72)GAT>CAT	p.D24H	C2orf56_uc010ynj.1_5'Flank|C2orf56_uc002rqa.3_5'Flank|C2orf56_uc002rqc.3_5'Flank|C2orf56_uc010ynk.1_5'Flank|C2orf56_uc010ynl.1_5'Flank	NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	24					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				TCGTCCGGATCTTCTACTGCC	0.602													0	0	0	1	0	34	103										G	37458641	C	G	37458641	3	3	65	1	0	0	0	0	1	0	0	0	3204	913	32	1	3158	1	CEBPZ	2	37458641	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	344738	37458641	205740732	172	19205										
TMEM178	130733	broad.mit.edu	37	chr2	39893156	39893156	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acggcgctcagcctcggcctCagcctgtgctccctggggct	13	17	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:39893156C>G	uc002rrt.2	+	1	67	c.42C>G	c.(40-42)CTC>CTG	p.L14L	TMEM178_uc010fam.1_Silent_p.L14L	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	14						integral to membrane					0		all_hematologic(82;0.248)				GCCTCGGCCTCAGCCTGTGCT	0.547													0	0	0	1	0	6	19										G	39893156	C	G	39893156	2	3	65	1	0	0	0	0	0	0	0	1	16092	813	29	1		1	TMEM178	2	39893156	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2434515	39893156	203306217	173	19206										
PLEKHH2	130271	broad.mit.edu	37	chr2	43924477	43924477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgaaagaacctgagttcactGaaggaaaagacatggaaggt	12	6	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:43924477G>A	uc010yny.1	+	7	753	c.670G>A	c.(670-672)GAA>AAA	p.E224K	PLEKHH2_uc002rte.3_Missense_Mutation_p.E224K|PLEKHH2_uc002rtf.3_Missense_Mutation_p.E223K	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	224						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGAGTTCACTGAAGGAAAAGA	0.358													0	0	0	1	0	15	44										A	43924477	G	A	43924477	3	1	65	1	0	0	0	0	1	0	0	0	12077	1291	45	1	692	1	PLEKHH2	2	43924477	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4031321	43924477	199274896	174	19207										
ABCG5	64240	broad.mit.edu	37	chr2	44050022	44050022	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccagcatcatctgccacttCtggtagaggccgtcctgact	10	14	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:44050022C>G	uc002rtn.2	-	10	1517	c.1377G>C	c.(1375-1377)CAG>CAC	p.Q459H	ABCG5_uc002rtm.2_Missense_Mutation_p.Q64H|ABCG5_uc002rto.2_Missense_Mutation_p.Q288H|ABCG5_uc002rtp.2_Missense_Mutation_p.Q64H	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	459	ABC transmembrane type-2.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCTGCCACTTCTGGTAGAGGC	0.572													0	0	0	1	0	17	35										G	44050022	C	G	44050022	3	3	65	1	0	0	0	0	1	0	0	0	71	912	32	1	594	1	ABCG5	2	44050022	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	125545	44050022	199149351	175	19208										
SIX2	10736	broad.mit.edu	37	chr2	45236023	45236023	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttggcgtggttgtgcggcGagaactggtggctctccagg	18	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:45236023G>C	uc002ruo.2	-	1	520	c.227C>G	c.(226-228)TCG>TGG	p.S76W	SIX2_uc002rup.2_Missense_Mutation_p.S76W	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	76						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTTGTGCGGCGAGAACTGGTG	0.627													0	0	0	1	0	30	112										C	45236023	G	C	45236023	3	2	65	1	0	0	0	0	1	0	0	0	14347	1059	37	1	656	1	SIX2	2	45236023	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1186001	45236023	197963350	176	19209										
EPAS1	2034	broad.mit.edu	37	chr2	46609643	46609643	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccacagcctccatctgccatCagtcccggggagaacagcaa	9	16	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:46609643C>T	uc002ruv.2	+	15	2855	c.2367C>T	c.(2365-2367)ATC>ATT	p.I789I	EPAS1_uc002ruw.2_Silent_p.I255I	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	789					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CATCTGCCATCAGTCCCGGGG	0.592													0	0	0	1	0	36	137										T	46609643	C	T	46609643	2	4	65	1	0	0	0	0	0	0	0	1	5150	816	29	1		1	EPAS1	2	46609643	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1373620	46609643	196589730	177	19210										
PSME4	23198	broad.mit.edu	37	chr2	54163918	54163918	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taccccctcccattgtgggaGattttgcactgaaacccaaa	7	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:54163918G>T	uc002rxp.2	-	6	798	c.742C>A	c.(742-744)CTC>ATC	p.L248I	PSME4_uc010yop.1_Missense_Mutation_p.L134I|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	248					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CATTGTGGGAGATTTTGCACT	0.353													1	0	1.10513e-12	1	1.15994e-12	21	56										T	54163918	G	T	54163918	3	4	65	1	0	0	0	0	1	0	0	0	12709	942	33	3	4953	3	PSME4	2	54163918	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7554275	54163918	189035455	178	19211										
SPTBN1	6711	broad.mit.edu	37	chr2	54856469	54856469	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggccaacctagagcagctctCggccattcggaagaagcgcc	12	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:54856469C>T	uc002rxu.2	+	14	2447	c.2198C>T	c.(2197-2199)TCG>TTG	p.S733L	SPTBN1_uc002rxv.1_Missense_Mutation_p.S733L|SPTBN1_uc002rxx.2_Missense_Mutation_p.S720L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	733	Spectrin 5.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GAGCAGCTCTCGGCCATTCGG	0.572													0	0	0	1	0	31	96										T	54856469	C	T	54856469	3	4	65	1	0	0	0	0	1	0	0	0	15118	893	31	1	2361	1	SPTBN1	2	54856469	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	692551	54856469	188342904	179	19212										
CCDC88A	55704	broad.mit.edu	37	chr2	55523455	55523455	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagagtaacaacttcacttCcaggggaaccagttttgatc	9	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:55523455C>T	uc002ryv.2	-	30	5869	c.5027G>A	c.(5026-5028)GGA>GAA	p.G1676E	CCDC88A_uc010yoz.1_Missense_Mutation_p.G1649E|CCDC88A_uc010ypa.1_Missense_Mutation_p.G1676E|CCDC88A_uc002ryt.2_5'UTR|CCDC88A_uc010fbw.2_Missense_Mutation_p.G178E|CCDC88A_uc002ryu.2_Missense_Mutation_p.G931E|CCDC88A_uc002rys.2_Missense_Mutation_p.G634E|CCDC88A_uc002ryw.2_Missense_Mutation_p.G960E|CCDC88A_uc010fby.1_Missense_Mutation_p.G528E	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1677					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						AACTTCACTTCCAGGGGAACC	0.398													0	0	0	1	0	16	54										T	55523455	C	T	55523455	3	4	65	1	0	0	0	0	1	0	0	0	2863	855	30	1	597	1	CCDC88A	2	55523455	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	666986	55523455	187675918	180	19213										
CCDC88A	55704	broad.mit.edu	37	chr2	55535955	55535955	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagcactcactgctgcttttCttggtccccaaggtctggcc	9	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:55535955C>G	uc002ryv.2	-	25	5216	c.4374G>C	c.(4372-4374)AAG>AAC	p.K1458N	CCDC88A_uc010yoz.1_Missense_Mutation_p.K1459N|CCDC88A_uc010ypa.1_Missense_Mutation_p.K1458N|CCDC88A_uc010fbw.2_Missense_Mutation_p.K82N|CCDC88A_uc002ryu.2_Missense_Mutation_p.K741N|CCDC88A_uc002rys.2_Missense_Mutation_p.K444N|CCDC88A_uc002ryw.2_Missense_Mutation_p.K742N|CCDC88A_uc010fby.1_Missense_Mutation_p.K338N	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1459					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TGCTGCTTTTCTTGGTCCCCA	0.393													0	0	0	1	0	14	30										G	55535955	C	G	55535955	3	3	65	1	0	0	0	0	1	0	0	0	2863	912	32	1	1270	1	CCDC88A	2	55535955	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	12500	55535955	187663418	181	19214										
UGP2	7360	broad.mit.edu	37	chr2	64112904	64112904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atatttttgtgtctaacataGataatctgggtgccacagtg	9	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:64112904G>C	uc002scm.2	+	6	1063	c.757G>C	c.(757-759)GAT>CAT	p.D253H	UGP2_uc002scl.2_Missense_Mutation_p.D242H|UGP2_uc010ypx.1_Missense_Mutation_p.D262H	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	253		Magnesium (By similarity).			glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						GTCTAACATAGATAATCTGGG	0.388													0	0	0	1	0	19	65										C	64112904	G	C	64112904	3	2	65	1	0	0	0	0	1	0	0	0	16940	942	33	1	779	1	UGP2	2	64112904	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8576949	64112904	179086469	182	19215										
DYSF	8291	broad.mit.edu	37	chr2	71883391	71883391	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaagacgcaggaggagacaGaagatccatctgtgattggt	14	7	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:71883391G>C	uc002sie.2	+	42	4985	c.4609G>C	c.(4609-4611)GAA>CAA	p.E1537Q	DYSF_uc010feg.2_Missense_Mutation_p.E1568Q|DYSF_uc010feh.2_Missense_Mutation_p.E1544Q|DYSF_uc002sig.3_Missense_Mutation_p.E1523Q|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.E1558Q|DYSF_uc010fef.2_Missense_Mutation_p.E1575Q|DYSF_uc010fei.2_Missense_Mutation_p.E1554Q|DYSF_uc010fek.2_Missense_Mutation_p.E1555Q|DYSF_uc010fej.2_Missense_Mutation_p.E1545Q|DYSF_uc010fel.2_Missense_Mutation_p.E1524Q|DYSF_uc010feo.2_Missense_Mutation_p.E1569Q|DYSF_uc010fem.2_Missense_Mutation_p.E1559Q|DYSF_uc010fen.2_Missense_Mutation_p.E1576Q|DYSF_uc002sif.2_Missense_Mutation_p.E1538Q|DYSF_uc010yqy.1_Missense_Mutation_p.E418Q|DYSF_uc010yqz.1_Missense_Mutation_p.E298Q	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1537	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GGAGGAGACAGAAGATCCATC	0.507													0	0	0	1	0	77	263										C	71883391	G	C	71883391	3	2	65	1	0	0	0	0	1	0	0	0	4859	943	33	1	5034	1	DYSF	2	71883391	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7770487	71883391	171315982	183	19216										
MAT2A	4144	broad.mit.edu	37	chr2	85768794	85768794	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtaacgtgctggtagccttgGagcaacagtcaccagatatt	11	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:85768794G>C	uc002spr.2	+	4	454	c.331G>C	c.(331-333)GAG>CAG	p.E111Q	MAT2A_uc010ysr.1_Missense_Mutation_p.E111Q|MAT2A_uc010fgk.2_Missense_Mutation_p.E85Q|MAT2A_uc010fgl.2_Missense_Mutation_p.E48Q|MAT2A_uc010fgm.1_Missense_Mutation_p.E48Q	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	111					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GGTAGCCTTGGAGCAACAGTC	0.408													0	0	0	1	0	12	40										C	85768794	G	C	85768794	3	2	65	1	0	0	0	0	1	0	0	0	9330	1175	41	1	345	1	MAT2A	2	85768794	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13885403	85768794	157430579	184	19217			1	87		5	4	1332	N	G	3.585669e-05
MAT2A	4144	broad.mit.edu	37	chr2	85769496	85769496	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttgttattggtgggcctcaGgtaatgtcattttgttgcat	11	5	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:85769496G>T	uc002spr.2	+	6	891	c.768G>T	c.(766-768)CAG>CAT	p.Q256H	MAT2A_uc010ysr.1_Missense_Mutation_p.Q256H|MAT2A_uc010fgk.2_Missense_Mutation_p.Q230H|MAT2A_uc010fgl.2_Missense_Mutation_p.Q193H|MAT2A_uc010fgm.1_3'UTR	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	256					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GTGGGCCTCAGGTAATGTCAT	0.383													1	0	0.014758	1	0.0148545	5	29										T	85769496	G	T	85769496	3	4	65	1	0	0	0	0	1	0	0	0	9330	1014	35	4	790	4	MAT2A	2	85769496	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	702	85769496	157429877	185	19218			1	87		5	4	1332	N	G	3.585669e-05
MAT2A	4144	broad.mit.edu	37	chr2	85770096	85770096	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atggtacctctcagaagagtGagagagagctattagagatt							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:85770096G>A	uc002spr.2	+	8	1147	c.1024G>A	c.(1024-1026)GAG>AAG	p.E342K	MAT2A_uc010ysr.1_Missense_Mutation_p.E342K|MAT2A_uc010fgk.2_Missense_Mutation_p.E316K|MAT2A_uc010fgl.2_Missense_Mutation_p.E279K	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	342					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TCAGAAGAGTGAGAGAGAGCT	0.403													0	0	0	1	0	15	62										A	85770096	G	A	85770096	3	1	65	1	0	0	0	0	1	0	0	0	9330	1291	45	1	1054	1	MAT2A	2	85770096	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	600	85770096	157429277	186	19219	95	2	1	87		5	4	1332	N	G	3.585669e-05
MAT2A	4144	broad.mit.edu	37	chr2	85770102	85770102	+	Missense_Mutation	SNP	G	G	C													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctctcagaagagtgagagaGagctattagagattgtgaag							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:85770102G>C	uc002spr.2	+	8	1153	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q	MAT2A_uc010ysr.1_Missense_Mutation_p.E344Q|MAT2A_uc010fgk.2_Missense_Mutation_p.E318Q|MAT2A_uc010fgl.2_Missense_Mutation_p.E281Q	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	344					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GAGTGAGAGAGAGCTATTAGA	0.408													0	0	0	1	0	17	61										C	85770102	G	C	85770102	3	2	65	1	0	0	0	0	1	0	0	0	9330	943	33	1	1060	1	MAT2A	2	85770102	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6	85770102	157429271	187	19220	95	2	1	87		5	4	1332	N	G	3.585669e-05
MAT2A	4144	broad.mit.edu	37	chr2	85770125	85770125	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctattagagattgtgaagaaGaatttcgatctccgccctgg	10	8	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:85770125G>C	uc002spr.2	+	8	1176	c.1053G>C	c.(1051-1053)AAG>AAC	p.K351N	MAT2A_uc010ysr.1_Missense_Mutation_p.K351N|MAT2A_uc010fgk.2_Missense_Mutation_p.K325N|MAT2A_uc010fgl.2_Missense_Mutation_p.K288N	NM_005911	NP_005902	P31153	METK2_HUMAN	methionine adenosyltransferase II, alpha	351					methylation|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0					L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TTGTGAAGAAGAATTTCGATC	0.413													0	0	0	1	0	16	60										C	85770125	G	C	85770125	3	2	65	1	0	0	0	0	1	0	0	0	9330	933	33	1	1083	1	MAT2A	2	85770125	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	23	85770125	157429248	188	19221			1	87		5	4	1332	N	G	3.585669e-05
C2orf68	388969	broad.mit.edu	37	chr2	85836187	85836187	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actcacctttcctgggtcatCaccctacgtggaggaagagt	10	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:85836187C>T	uc002sqc.2	-	4	454	c.382G>A	c.(382-384)GAT>AAT	p.D128N	USP39_uc002sqb.2_Intron	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	128										central_nervous_system(1)	1						CCTGGGTCATCACCCTACGTG	0.552													0	0	0	1	0	17	45										T	85836187	C	T	85836187	3	4	65	1	0	0	0	0	1	0	0	0	2187	826	29	1	122	1	C2orf68	2	85836187	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	66062	85836187	157363186	189	19222										
LMAN2L	81562	broad.mit.edu	37	chr2	97403767	97403767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcatcaccatggcattgccCatcagattccacagtgagga	9	12	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:97403767C>T	uc002swu.2	-	2	261	c.225G>A	c.(223-225)ATG>ATA	p.M75I	LMAN2L_uc002swv.2_Missense_Mutation_p.M75I|LMAN2L_uc010yut.1_5'UTR|LMAN2L_uc010yuu.1_Intron|LMAN2L_uc010yuv.1_Intron|LMAN2L_uc010yuw.1_Intron|LMAN2L_uc002sww.2_5'UTR|LMAN2L_uc010yux.1_5'UTR	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	75	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						TGGCATTGCCCATCAGATTCC	0.493													0	0	0	1	0	16	24										T	97403767	C	T	97403767	3	4	65	1	0	0	0	0	1	0	0	0	8839	594	21	2	886	2	LMAN2L	2	97403767	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11567580	97403767	145795606	190	19223										
C2orf49	79074	broad.mit.edu	37	chr2	105954067	105954067	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcgggggatgtgggcggtcGcagctgcacggactcggaac	20	10	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:105954067G>A	uc002tcs.1	+	1	55	c.23G>A	c.(22-24)CGC>CAC	p.R8H	C2orf49_uc010fjd.1_Missense_Mutation_p.R8H	NM_024093	NP_076998	Q9BVC5	ASHWN_HUMAN	ashwin	8						tRNA-splicing ligase complex					0						GTGGGCGGTCGCAGCTGCACG	0.672													0	0	0	1	0	11	28										A	105954067	G	A	105954067	3	1	65	1	0	0	0	0	1	0	0	0	2171	1087	38	2	25	2	C2orf49	2	105954067	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8550300	105954067	137245306	191	19224										
RANBP2	5903	broad.mit.edu	37	chr2	109381763	109381763	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttttaagtttggtacttcaGagacaagcaaggctccaaag	9	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:109381763G>A	uc002tem.3	+	20	4894	c.4768G>A	c.(4768-4770)GAG>AAG	p.E1590K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1590					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGGTACTTCAGAGACAAGCAA	0.453													0	0	0	1	0	43	125										A	109381763	G	A	109381763	3	1	65	1	0	0	0	0	1	0	0	0	13028	943	33	1	4846	1	RANBP2	2	109381763	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3427696	109381763	133817610	192	19225										
CCDC138	165055	broad.mit.edu	37	chr2	109411132	109411132	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtttacttccacatcagatCagtcagatatatgacgaatt	6	8	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:109411132C>G	uc002ten.1	+	5	591	c.531C>G	c.(529-531)ATC>ATG	p.I177M	CCDC138_uc002teo.1_Missense_Mutation_p.I177M|CCDC138_uc002tep.1_Translation_Start_Site|CCDC138_uc010fjm.1_Translation_Start_Site	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	177											0						CACATCAGATCAGTCAGATAT	0.373													0	0	0	1	0	12	47										G	109411132	C	G	109411132	3	3	65	1	0	0	0	0	1	0	0	0	2772	816	29	1	549	1	CCDC138	2	109411132	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	29369	109411132	133788241	193	19226										
BUB1	699	broad.mit.edu	37	chr2	111425410	111425410	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacaagctgaagatatcactCcagaaagctctgaaccctaa	6	12	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:111425410C>G	uc002tgc.2	-	7	696	c.584G>C	c.(583-585)GGA>GCA	p.G195A	BUB1_uc010yxh.1_Missense_Mutation_p.G175A|BUB1_uc010fkb.2_Missense_Mutation_p.G195A|BUB1_uc002tgd.2_Missense_Mutation_p.G195A	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	195					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		AGATATCACTCCAGAAAGCTC	0.323													0	0	0	1	0	14	72										G	111425410	C	G	111425410	3	3	65	1	0	0	0	0	1	0	0	0	1570	855	30	1	2749	1	BUB1	2	111425410	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2014278	111425410	131773963	194	19227										
IL1B	3553	broad.mit.edu	37	chr2	113590374	113590374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcatcgtgcacataagcctCgttatcccatgtgtcgaaga	9	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:113590374C>T	uc002tii.1	-	5	418	c.331G>A	c.(331-333)GAG>AAG	p.E111K	IL1B_uc002tih.1_Missense_Mutation_p.E80K	NM_000576	NP_000567	P01584	IL1B_HUMAN	interleukin 1, beta proprotein	111					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding	p.E111K(1)		lung(3)|breast(1)	4					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	ACATAAGCCTCGTTATCCCAT	0.488													0	0	0	1	0	29	101										T	113590374	C	T	113590374	3	4	65	1	0	0	0	0	1	0	0	0	7651	893	31	1	490	1	IL1B	2	113590374	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2164964	113590374	129608999	195	19228										
IL1F7	27178	broad.mit.edu	37	chr2	113676180	113676180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgcccaaaaggaatcagcaCgccggcccttcatcttttat	7	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:113676180C>T	uc002tij.2	+	5	493	c.451C>T	c.(451-453)CGC>TGC	p.R151C	IL1F7_uc002tik.2_Missense_Mutation_p.R130C|IL1F7_uc002til.2_Missense_Mutation_p.R111C|IL1F7_uc002tim.2_Missense_Mutation_p.R90C|IL1F7_uc002tin.2_Missense_Mutation_p.R125C	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	151					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						GGAATCAGCACGCCGGCCCTT	0.517													0	0	0	1	0	12	47										T	113676180	C	T	113676180	3	4	65	1	0	0	0	0	1	0	0	0	7655	536	19	2	540	2	IL1F7	2	113676180	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	85806	113676180	129523193	196	19229										
GLI2	2736	broad.mit.edu	37	chr2	121740439	121740439	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accgcgccaagcaccagaatCgcacccactccaacgaggta	8	17	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:121740439C>G	uc010flp.2	+	10	1696	c.1666C>G	c.(1666-1668)CGC>GGC	p.R556G	GLI2_uc002tmq.1_Missense_Mutation_p.R228G|GLI2_uc002tmr.1_Missense_Mutation_p.R211G|GLI2_uc002tmt.3_Missense_Mutation_p.R228G|GLI2_uc002tmu.3_Missense_Mutation_p.R211G|GLI2_uc002tmw.1_Missense_Mutation_p.R539G	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	556	C2H2-type 4.				axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCACCAGAATCGCACCCACTC	0.627													0	0	0	1	0	18	91										G	121740439	C	G	121740439	3	3	65	1	0	0	0	0	1	0	0	0	6438	884	31	1	1704	1	GLI2	2	121740439	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8064259	121740439	121458934	197	19230										
TFCP2L1	29842	broad.mit.edu	37	chr2	122004422	122004422	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttgatctggcagctggctGagtgcaggtgctccgtgtac	14	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:122004422G>A	uc002tmx.2	-	6	722	c.629C>T	c.(628-630)TCA>TTA	p.S210L	TFCP2L1_uc010flr.2_Missense_Mutation_p.S210L	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	210					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GCAGCTGGCTGAGTGCAGGTG	0.602													0	0	0	1	0	31	137										A	122004422	G	A	122004422	3	1	65	1	0	0	0	0	1	0	0	0	15793	1294	45	1	850	1	TFCP2L1	2	122004422	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	263983	122004422	121194951	198	19231										
IWS1	55677	broad.mit.edu	37	chr2	128253659	128253659	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgccaccatcgcggttccgtCtgcgcttgccactcatgctc	9	17	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:128253659C>T	uc002ton.2	-	7	1934	c.1631G>A	c.(1630-1632)AGA>AAA	p.R544K	IWS1_uc010yzl.1_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	544					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		GCGGTTCCGTCTGCGCTTGCC	0.468													0	0	0	1	0	78	249										T	128253659	C	T	128253659	3	4	65	1	0	0	0	0	1	0	0	0	7931	913	32	1	860	1	IWS1	2	128253659	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6249237	128253659	114945714	199	19232										
UGGT1	56886	broad.mit.edu	37	chr2	128939716	128939716	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctccagattgtacgaacaGatctgaaagagttaagagat	9	6	2	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:128939716G>A	uc002tps.2	+	37	4274	c.4096G>A	c.(4096-4098)GAT>AAT	p.D1366N	UGGT1_uc002tpr.2_Missense_Mutation_p.D1342N	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1366	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TGTACGAACAGATCTGAAAGA	0.428													0	0	0	1	0	32	94										A	128939716	G	A	128939716	3	1	65	1	0	0	0	0	1	0	0	0	16938	942	33	1	4242	1	UGGT1	2	128939716	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	686057	128939716	114259657	200	19233										
SMPD4	55627	broad.mit.edu	37	chr2	130922009	130922009	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atagtgatgaagccacatttCaacaaaaacctgcaaaaaag	6	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:130922009C>T	uc002tqq.1	-	10	1439	c.919G>A	c.(919-921)GAA>AAA	p.E307K	SMPD4_uc002tqp.1_5'UTR|SMPD4_uc010yzy.1_Missense_Mutation_p.E85K|SMPD4_uc010yzz.1_5'UTR|SMPD4_uc002tqr.1_Missense_Mutation_p.E307K|SMPD4_uc002tqs.1_Missense_Mutation_p.E175K|SMPD4_uc002tqt.1_Missense_Mutation_p.E185K|SMPD4_uc010zaa.1_Missense_Mutation_p.E194K|SMPD4_uc010zab.1_Missense_Mutation_p.E234K|SMPD4_uc010zac.1_Silent_p.L20L|SMPD4_uc010zad.1_Silent_p.L20L	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	268					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	AGCCACATTTCAACAAAAACC	0.259													0	0	0	1	0	15	33										T	130922009	C	T	130922009	3	4	65	1	0	0	0	0	1	0	0	0	14807	835	29	1	1725	1	SMPD4	2	130922009	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1982293	130922009	112277364	201	19234										
NCKAP5	344148	broad.mit.edu	37	chr2	133539884	133539884	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaaaagaaggcccaggcttCtgctttgcttccacagaggt	11	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:133539884C>T	uc002ttp.2	-	14	4874	c.4500G>A	c.(4498-4500)CAG>CAA	p.Q1500Q	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1500							protein binding				0						GCCCAGGCTTCTGCTTTGCTT	0.473													0	0	0	1	0	25	64										T	133539884	C	T	133539884	2	4	65	1	0	0	0	0	0	0	0	1	10223	912	32	1		1	NCKAP5	2	133539884	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2617875	133539884	109659489	202	19235										
NEB	4703	broad.mit.edu	37	chr2	152468834	152468834	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagctctcttcactttctCgacctctacagagccaatgg	6	15	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:152468834C>G	uc010fnx.2	-	74	11133	c.10942G>C	c.(10942-10944)GAG>CAG	p.E3648Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3648	Nebulin 100.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCACTTTCTCGACCTCTACA	0.438													0	0	0	1	0	7	38										G	152468834	C	G	152468834	3	3	65	1	0	0	0	0	1	0	0	0	10302	893	31	1	14435	1	NEB	2	152468834	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	18928950	152468834	90730539	203	19236										
FMNL2	114793	broad.mit.edu	37	chr2	153399292	153399292	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcctccccatacatacattCaaaagctcaaaggctatctg	4	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:153399292C>G	uc002tye.2	+	3	608	c.241C>G	c.(241-243)CAA>GAA	p.Q81E		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	81	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						TACATACATTCAAAAGCTCAA	0.438													0	0	0	1	0	10	36										G	153399292	C	G	153399292	3	3	65	1	0	0	0	0	1	0	0	0	5952	827	29	1	251	1	FMNL2	2	153399292	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	930458	153399292	89800081	204	19237										
TANC1	85461	broad.mit.edu	37	chr2	160050816	160050816	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccaacgtgaactacaggacaGaagtgttaaataatgcccca	8	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:160050816G>A	uc002uag.2	+	17	3065	c.2791G>A	c.(2791-2793)GAA>AAA	p.E931K	TANC1_uc010zcm.1_Missense_Mutation_p.E923K|TANC1_uc010fom.1_Missense_Mutation_p.E737K	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	931						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CTACAGGACAGAAGTGTTAAA	0.517													0	0	0	1	0	24	87										A	160050816	G	A	160050816	3	1	65	1	0	0	0	0	1	0	0	0	15541	943	33	1	2849	1	TANC1	2	160050816	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6651524	160050816	83148557	205	19238										
TANC1	85461	broad.mit.edu	37	chr2	160050867	160050867	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagtctcaccttggccacGaggaagttgtcactctgctc	9	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:160050867G>A	uc002uag.2	+	17	3116	c.2842G>A	c.(2842-2844)GAG>AAG	p.E948K	TANC1_uc010zcm.1_Missense_Mutation_p.E940K|TANC1_uc010fom.1_Missense_Mutation_p.E754K	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	948	ANK 2.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCTTGGCCACGAGGAAGTTGT	0.557													0	0	0	1	0	23	75										A	160050867	G	A	160050867	3	1	65	1	0	0	0	0	1	0	0	0	15541	1059	37	1	2900	1	TANC1	2	160050867	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	51	160050867	83148506	206	19239										
MARCH7	64844	broad.mit.edu	37	chr2	160599728	160599728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaactgtactacctcagctGggagaaatgttggaaatggt	11	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:160599728G>A	uc002uax.2	+	3	432	c.310G>A	c.(310-312)GGG>AGG	p.G104R	MARCH7_uc010foq.2_Missense_Mutation_p.G104R|MARCH7_uc010zcn.1_Missense_Mutation_p.G104R|MARCH7_uc010for.2_Missense_Mutation_p.G66R	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	104	Ser-rich.						ligase activity|zinc ion binding				0						TACCTCAGCTGGGAGAAATGT	0.403													0	0	0	1	0	25	48										A	160599728	G	A	160599728	3	1	65	1	0	0	0	0	1	0	0	0	9306	1348	47	2	316	2	MARCH7	2	160599728	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	548861	160599728	82599645	207	19240										
ITGB6	3694	broad.mit.edu	37	chr2	161052112	161052112	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggcggacatgcacctgcaGagtctgcgcaccacctgcaa	11	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:161052112G>A	uc002ubh.2	-	4	377	c.361C>T	c.(361-363)CTG>TTG	p.L121L	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Silent_p.L121L|ITGB6_uc010zcq.1_Silent_p.L79L|ITGB6_uc010fov.1_Silent_p.L121L	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	121	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						TGCACCTGCAGAGTCTGCGCA	0.522													0	0	0	1	0	16	63										A	161052112	G	A	161052112	2	1	65	1	0	0	0	0	0	0	0	1	7899	933	33	1		1	ITGB6	2	161052112	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	452384	161052112	82147261	208	19241										
KCNH7	90134	broad.mit.edu	37	chr2	163360985	163360985	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcagtcacattgtgtgttcGatctttaaccttgggtgcaa	9	9	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:163360985G>A	uc002uch.1	-	6	1308	c.1096C>T	c.(1096-1098)CGA>TGA	p.R366*	KCNH7_uc002uci.2_Nonsense_Mutation_p.R359*	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	366	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTGTGTGTTCGATCTTTAACC	0.373													0	0	0	1	0	17	63										A	163360985	G	A	163360985	4	1	65	1	0	0	0	0	0	1	0	0	8037	1066	37	1	2604	1	KCNH7	2	163360985	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2308873	163360985	79838388	209	19242										
SCN3A	6328	broad.mit.edu	37	chr2	166020150	166020150	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaatgactgaaattgttttCagtgctcggagaactctgaa	11	6	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:166020150C>G	uc002ucx.2	-	7	1164	c.672G>C	c.(670-672)CTG>CTC	p.L224L	SCN3A_uc002ucy.2_Silent_p.L224L|SCN3A_uc002ucz.2_Intron|SCN3A_uc002uda.1_Silent_p.L93L|SCN3A_uc002udb.1_Intron	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	224	Helical; Voltage-sensor; Name=S4 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	AAATTGTTTTCAGTGCTCGGA	0.403													0	0	0	1	0	12	22										G	166020150	C	G	166020150	2	3	65	1	0	0	0	0	0	0	0	1	13918	813	29	1		1	SCN3A	2	166020150	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2659165	166020150	77179223	210	19243										
TTC21B	79809	broad.mit.edu	37	chr2	166747063	166747063	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggattcaaacagatctctatCatattataaagggcattttg	7	6	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:166747063C>G	uc002udk.2	-	24	3322	c.3189G>C	c.(3187-3189)ATG>ATC	p.M1063I	TTC21B_uc002udj.1_RNA	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	1063						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						AGATCTCTATCATATTATAAA	0.388													0	0	0	1	0	14	35										G	166747063	C	G	166747063	3	3	65	1	0	0	0	0	1	0	0	0	16685	826	29	1	785	1	TTC21B	2	166747063	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	726913	166747063	76452310	211	19244										
SCN9A	6335	broad.mit.edu	37	chr2	167159651	167159651	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattatgctttctaatgtttCattattttcaagtgaatttc	4	6	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:167159651C>T	uc010fpl.2	-	7	1191	c.850G>A	c.(850-852)GAA>AAA	p.E284K	SCN9A_uc002udr.1_Missense_Mutation_p.E155K|SCN9A_uc002uds.1_Missense_Mutation_p.E155K|SCN9A_uc002udt.1_Missense_Mutation_p.E155K	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	284	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTAATGTTTCATTATTTTCA	0.343													0	0	0	1	0	6	17										T	167159651	C	T	167159651	3	4	65	1	0	0	0	0	1	0	0	0	13925	835	29	1	5167	1	SCN9A	2	167159651	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	412588	167159651	76039722	212	19245										
KLHL23	151230	broad.mit.edu	37	chr2	170606109	170606109	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgtatttatgtcactggagGatactcctactcaaagggaa	9	7	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:170606109G>T	uc002ufh.1	+	6	1882	c.1544G>T	c.(1543-1545)GGA>GTA	p.G515V	KLHL23_uc002ufi.1_Missense_Mutation_p.G515V|uc002ufj.3_5'Flank	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	515	Kelch 6.										0						GTCACTGGAGGATACTCCTAC	0.448													1	0	7.87624e-14	1	8.28229e-14	23	76										T	170606109	G	T	170606109	3	4	65	1	0	0	0	0	1	0	0	0	8378	1174	41	3	1554	3	KLHL23	2	170606109	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3446458	170606109	72593264	213	19246										
GORASP2	26003	broad.mit.edu	37	chr2	171806117	171806117	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagcctgtaaagatgcttatCtatagcagcaaaacattgga	8	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:171806117C>G	uc002ugk.2	+	3	353	c.213C>G	c.(211-213)ATC>ATG	p.I71M	GORASP2_uc002ugj.2_Missense_Mutation_p.I3M|GORASP2_uc010zdl.1_Missense_Mutation_p.I83M|GORASP2_uc010zdm.1_Missense_Mutation_p.I27M|GORASP2_uc002ugl.2_Missense_Mutation_p.I3M	NM_015530	NP_056345	Q9H8Y8	GORS2_HUMAN	golgi reassembly stacking protein 2	71	PDZ.					Golgi membrane				breast(1)|central_nervous_system(1)	2						AGATGCTTATCTATAGCAGCA	0.438													0	0	0	1	0	31	93										G	171806117	C	G	171806117	3	3	65	1	0	0	0	0	1	0	0	0	6576	903	32	1	223	1	GORASP2	2	171806117	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1200008	171806117	71393256	214	19247										
HAT1	8520	broad.mit.edu	37	chr2	172803292	172803292	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctgagtatacccatcaactCtttggggatgagtaagtaac	9	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:172803292C>G	uc002uhi.2	+	3	253	c.177C>G	c.(175-177)CTC>CTG	p.L59L	HAT1_uc010fqi.2_5'UTR|HAT1_uc002uhj.2_Intron	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	59					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CCCATCAACTCTTTGGGGATG	0.264													0	0	0	1	0	16	37										G	172803292	C	G	172803292	2	3	65	1	0	0	0	0	0	0	0	1	6964	900	32	1		1	HAT1	2	172803292	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	997175	172803292	70396081	215	19248										
ZAK	51776	broad.mit.edu	37	chr2	174131031	174131031	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacttctcttccctacatctCaactctagggacagtggctt	6	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:174131031C>G	uc002uhz.2	+	20	2156	c.1956C>G	c.(1954-1956)CTC>CTG	p.L652L	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	652					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			CCCTACATCTCAACTCTAGGG	0.468													0	0	0	1	0	17	74										G	174131031	C	G	174131031	2	3	65	1	0	0	0	0	0	0	0	1	17509	813	29	1		1	ZAK	2	174131031	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1327739	174131031	69068342	216	19249										
CHN1	1123	broad.mit.edu	37	chr2	175673765	175673765	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacagaaatatctgccttctCaccatcttttaaggatgttg	6	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:175673765C>T	uc002uji.2	-	11	1500	c.970G>A	c.(970-972)GAG>AAG	p.E324K	CHN1_uc010zeq.1_Missense_Mutation_p.E298K|CHN1_uc002ujj.2_Missense_Mutation_p.E99K|CHN1_uc002ujg.2_Missense_Mutation_p.E199K	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	324	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TCTGCCTTCTCACCATCTTTT	0.318			T	TAF15	extraskeletal myxoid chondrosarcoma								0	0	0	1	0	9	32										T	175673765	C	T	175673765	3	4	65	1	0	0	0	0	1	0	0	0	3362	835	29	1	421	1	CHN1	2	175673765	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1542734	175673765	67525608	217	19250										
TTN	7273	broad.mit.edu	37	chr2	179399910	179399910	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctcatagagttccttggttGaagagtgagatgctttagtc	11	6	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:179399910G>A	uc010zfg.1	-	307	93952	c.93728C>T	c.(93727-93729)TCA>TTA	p.S31243L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S24938L|TTN_uc010zfi.1_Missense_Mutation_p.S24871L|TTN_uc010zfj.1_Missense_Mutation_p.S24746L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32170							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTTGGTTGAAGAGTGAGA	0.408													0	0	0	1	0	18	59										A	179399910	G	A	179399910	3	1	65	1	0	0	0	0	1	0	0	0	16732	1294	45	1	6567	1	TTN	2	179399910	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3726145	179399910	63799463	218	19251										
TTN	7273	broad.mit.edu	37	chr2	179478785	179478785	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attgagaaacttaccaaactGatatttggctgttattggag	9	5	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:179478785G>A	uc010zfg.1	-	211	41859	c.41635C>T	c.(41635-41637)CAG>TAG	p.Q13879*	uc002ump.1_RNA|TTN_uc010zfh.1_Nonsense_Mutation_p.Q7574*|TTN_uc010zfi.1_Nonsense_Mutation_p.Q7507*|TTN_uc010zfj.1_Nonsense_Mutation_p.Q7382*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14806							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACCAAACTGATATTTGGCT	0.343													0	0	0	1	0	7	19										A	179478785	G	A	179478785	4	1	65	1	0	0	0	0	0	1	0	0	16732	1299	45	1	58758	1	TTN	2	179478785	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	78875	179478785	63720588	219	19252										
TTN	7273	broad.mit.edu	37	chr2	179640629	179640629	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgactcttcaggcactttttCatgggtaattctttcagccc	7	12	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:179640629C>T	uc010zfg.1	-	28	6186	c.5962G>A	c.(5962-5964)GAA>AAA	p.E1988K	TTN_uc010zfh.1_Missense_Mutation_p.E1942K|TTN_uc010zfi.1_Missense_Mutation_p.E1942K|TTN_uc010zfj.1_Missense_Mutation_p.E1942K|TTN_uc002unb.2_Missense_Mutation_p.E1988K|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1988							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCACTTTTTCATGGGTAATT	0.443													0	0	0	1	0	41	149										T	179640629	C	T	179640629	3	4	65	1	0	0	0	0	1	0	0	0	16732	835	29	1	105366	1	TTN	2	179640629	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	161844	179640629	63558744	220	19253										
ZNF385B	151126	broad.mit.edu	37	chr2	180348114	180348114	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcgttgcgtctagtgctttGaccttcttggcatgtttact	9	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:180348114G>C	uc002unn.3	-	6	1159	c.555C>G	c.(553-555)GTC>GTG	p.V185V	ZNF385B_uc002unj.2_Silent_p.V83V|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.V82V|ZNF385B_uc002unm.2_Silent_p.V109V	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	185	Matrin-type 2.					nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			CTAGTGCTTTGACCTTCTTGG	0.458													0	0	0	1	0	10	66										C	180348114	G	C	180348114	2	2	65	1	0	0	0	0	0	0	0	1	17874	1277	45	1		1	ZNF385B	2	180348114	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	707485	180348114	62851259	221	19254										
STAT1	6772	broad.mit.edu	37	chr2	191854376	191854376	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgactttcaaattataattCagctcttgcaatttcaccaa	3	9	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:191854376C>T	uc002usj.2	-	12	1450	c.1062G>A	c.(1060-1062)CTG>CTA	p.L354L	STAT1_uc010fse.1_Silent_p.L354L|STAT1_uc002usk.2_Silent_p.L354L|STAT1_uc002usl.2_Silent_p.L356L|STAT1_uc010fsf.1_Silent_p.L166L	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	354					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AATTATAATTCAGCTCTTGCA	0.249													0	0	0	1	0	4	5										T	191854376	C	T	191854376	2	4	65	1	0	0	0	0	0	0	0	1	15263	813	29	1		1	STAT1	2	191854376	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11506262	191854376	51344997	222	19255										
HECW2	57520	broad.mit.edu	37	chr2	197157303	197157303	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgttaccttgccctggtgatCatgtttcatttcccatcccc	6	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:197157303C>T	uc002utm.1	-	14	3169	c.2986G>A	c.(2986-2988)GAT>AAT	p.D996N	HECW2_uc002utl.1_Missense_Mutation_p.D640N	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	996	Interaction with TP73.|WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CCCTGGTGATCATGTTTCATT	0.552													0	0	0	1	0	29	84										T	197157303	C	T	197157303	3	4	65	1	0	0	0	0	1	0	0	0	7043	826	29	1	1796	1	HECW2	2	197157303	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5302927	197157303	46042070	223	19256										
HSPD1	3329	broad.mit.edu	37	chr2	198353941	198353941	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgaggctgaacgtcttcaaGattcagggtcaatccctctt	9	10	5	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:198353941G>A	uc002uui.2	-	9	1137	c.1000C>T	c.(1000-1002)CTT>TTT	p.L334F	HSPD1_uc002uuj.2_Missense_Mutation_p.L332F|HSPD1_uc010zgx.1_Missense_Mutation_p.L325F|HSPD1_uc010fsm.2_Missense_Mutation_p.L145F|HSPD1_uc002uuk.2_Missense_Mutation_p.L334F	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	334					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			ACGTCTTCAAGATTCAGGGTC	0.398													0	0	0	1	0	19	42										A	198353941	G	A	198353941	3	1	65	1	0	0	0	0	1	0	0	0	7428	942	33	1	737	1	HSPD1	2	198353941	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1196638	198353941	44845432	224	19257										
NIF3L1	60491	broad.mit.edu	37	chr2	201760084	201760084	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccggaacaaacaactttatCagaagacggaaattctgtca	7	10	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:201760084C>T	uc002uwm.2	+	4	788	c.697C>T	c.(697-699)CAG>TAG	p.Q233*	NIF3L1_uc002uwl.2_Nonsense_Mutation_p.Q206*|NIF3L1_uc002uwn.2_Nonsense_Mutation_p.Q206*|NIF3L1_uc002uwo.2_Nonsense_Mutation_p.Q233*|NIF3L1_uc002uwp.2_Nonsense_Mutation_p.Q233*|NIF3L1_uc002uwq.2_Nonsense_Mutation_p.Q233*	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	233					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						ACAACTTTATCAGAAGACGGA	0.328													0	0	0	1	0	17	57										T	201760084	C	T	201760084	4	4	65	1	0	0	0	0	0	1	0	0	10416	827	29	1	707	1	NIF3L1	2	201760084	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3406143	201760084	41439289	225	19258										
NIF3L1	60491	broad.mit.edu	37	chr2	201768234	201768234	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taggtgagatgtcccatcatGatactttggatgctgcttcc	10	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:201768234G>A	uc002uwm.2	+	7	1058	c.967G>A	c.(967-969)GAT>AAT	p.D323N	NIF3L1_uc002uwl.2_Missense_Mutation_p.D296N|NIF3L1_uc002uwn.2_Missense_Mutation_p.D296N|NIF3L1_uc002uwo.2_Missense_Mutation_p.D323N|NIF3L1_uc002uwp.2_Missense_Mutation_p.D323N|NIF3L1_uc002uwq.2_Missense_Mutation_p.M276I	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	323					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						GTCCCATCATGATACTTTGGA	0.408													0	0	0	1	0	23	68										A	201768234	G	A	201768234	3	1	65	1	0	0	0	0	1	0	0	0	10416	1290	45	1	989	1	NIF3L1	2	201768234	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8150	201768234	41431139	226	19259										
CASP8	841	broad.mit.edu	37	chr2	202139648	202139648	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtaatgacaatctcggactCtccaagagaacaggatagtg	11	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:202139648C>G	uc002uxr.1	+	7	841	c.632C>G	c.(631-633)TCT>TGT	p.S211C	CASP8_uc002uxo.1_Intron|CASP8_uc002uxp.1_Missense_Mutation_p.S228C|CASP8_uc002uxq.1_Missense_Mutation_p.S196C|CASP8_uc002uxt.1_Missense_Mutation_p.S270C|CASP8_uc002uxu.1_RNA|CASP8_uc002uxv.1_Missense_Mutation_p.S196C|CASP8_uc002uxw.1_Missense_Mutation_p.S196C|CASP8_uc002uxy.1_Missense_Mutation_p.S211C|CASP8_uc002uxx.1_Missense_Mutation_p.S196C|CASP8_uc010ftf.2_Intron|CASP8_uc010fte.1_Intron	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	211					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ATCTCGGACTCTCCAAGAGAA	0.388										HNSCC(4;0.00038)			0	0	0	1	0	11	27										G	202139648	C	G	202139648	3	3	65	1	0	0	0	0	1	0	0	0	2677	913	32	1	931	1	CASP8	2	202139648	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	371414	202139648	41059725	227	19260										
ALS2CR11	151254	broad.mit.edu	37	chr2	202430471	202430471	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctttcccggggttgttgctGaagtttttcaagtcgcacta	10	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:202430471G>C	uc002uye.2	-	9	1006	c.958C>G	c.(958-960)CAG>GAG	p.Q320E	ALS2CR11_uc002uyf.2_Missense_Mutation_p.Q320E|ALS2CR11_uc010fti.2_Missense_Mutation_p.Q320E	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	320										large_intestine(1)|ovary(1)|skin(1)	3						GGTTGTTGCTGAAGTTTTTCA	0.358													0	0	0	1	0	4	12										C	202430471	G	C	202430471	3	2	65	1	0	0	0	0	1	0	0	0	552	1299	45	1	4683	1	ALS2CR11	2	202430471	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	290823	202430471	40768902	228	19261										
ALS2CR8	79800	broad.mit.edu	37	chr2	203847053	203847053	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgcaatggacgagctggtaGaagttggagatgttgaggat	16	3	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:203847053G>C	uc002uzo.2	+	15	2228	c.1948G>C	c.(1948-1950)GAA>CAA	p.E650Q	ALS2CR8_uc010zia.1_Missense_Mutation_p.E574Q|ALS2CR8_uc010zib.1_Missense_Mutation_p.E574Q|ALS2CR8_uc010zic.1_Missense_Mutation_p.E562Q|ALS2CR8_uc002uzp.2_Missense_Mutation_p.E650Q	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	650										large_intestine(1)|ovary(1)	2						CGAGCTGGTAGAAGTTGGAGA	0.428													0	0	0	1	0	10	42										C	203847053	G	C	203847053	3	2	65	1	0	0	0	0	1	0	0	0	555	943	33	1	1998	1	ALS2CR8	2	203847053	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1416582	203847053	39352320	229	19262										
NBEAL1	65065	broad.mit.edu	37	chr2	204002904	204002904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtttgctacaaaagatgttaGaatgggcaatctcagaaaac	9	6	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:204002904G>C	uc002uzt.3	+	29	4831	c.4498G>C	c.(4498-4500)GAA>CAA	p.E1500Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E210Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1500							binding			ovary(1)|skin(1)	2						AAAGATGTTAGAATGGGCAAT	0.358													0	0	0	1	0	12	32										C	204002904	G	C	204002904	3	2	65	1	0	0	0	0	1	0	0	0	10188	943	33	1	4608	1	NBEAL1	2	204002904	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	155851	204002904	39196469	230	19263										
RAPH1	65059	broad.mit.edu	37	chr2	204354725	204354725	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttgacgcttactgtttcctGaaccaatgctgctgagctcc	8	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:204354725G>A	uc002vad.2	-	4	539	c.314C>T	c.(313-315)TCA>TTA	p.S105L	RAPH1_uc002vae.2_Missense_Mutation_p.S105L|RAPH1_uc002vaf.2_Missense_Mutation_p.S105L	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	105					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						ACTGTTTCCTGAACCAATGCT	0.443													0	0	0	1	0	32	120										A	204354725	G	A	204354725	3	1	65	1	0	0	0	0	1	0	0	0	13050	1294	45	1	3653	1	RAPH1	2	204354725	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	351821	204354725	38844648	231	19264										
RAPH1	65059	broad.mit.edu	37	chr2	204354805	204354805	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccacagtctctccctgattCagagcttctgcaatgaacaa	6	13	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:204354805C>T	uc002vad.2	-	4	459	c.234G>A	c.(232-234)CTG>CTA	p.L78L	RAPH1_uc002vae.2_Silent_p.L78L|RAPH1_uc002vaf.2_Silent_p.L78L	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	78					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						CTCCCTGATTCAGAGCTTCTG	0.378													0	0	0	1	0	17	87										T	204354805	C	T	204354805	2	4	65	1	0	0	0	0	0	0	0	1	13050	813	29	1		1	RAPH1	2	204354805	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	80	204354805	38844568	232	19265										
PARD3B	117583	broad.mit.edu	37	chr2	206166207	206166207	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacggtctgtctgataagagCtctcactctggccaaggagc	12	11	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:206166207C>T	uc002var.1	+	18	2619	c.2412C>T	c.(2410-2412)AGC>AGT	p.S804S	PARD3B_uc010fub.1_Silent_p.S804S|PARD3B_uc002vao.1_Silent_p.S804S|PARD3B_uc002vap.1_Silent_p.S742S|PARD3B_uc002vaq.1_Silent_p.S735S	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	804					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CTGATAAGAGCTCTCACTCTG	0.438													0	0	0	1	0	31	82										T	206166207	C	T	206166207	2	4	65	1	0	0	0	0	0	0	0	1	11444	796	28	2		2	PARD3B	2	206166207	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1811402	206166207	37033166	233	19266										
INO80D	54891	broad.mit.edu	37	chr2	206882459	206882459	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgtgtaatgtcaaaaactGgcacagagcactgctgtcca	10	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:206882459G>A	uc002vaz.3	-	8	1892	c.1487C>T	c.(1486-1488)CCA>CTA	p.P496L		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	496					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GTCAAAAACTGGCACAGAGCA	0.363													0	0	0	1	0	11	32										A	206882459	G	A	206882459	3	1	65	1	0	0	0	0	1	0	0	0	7749	1348	47	2	1612	2	INO80D	2	206882459	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	716252	206882459	36316914	234	19267										
ZDBF2	57683	broad.mit.edu	37	chr2	207169625	207169625	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attccagacctcataaatctCaggaaggcacgcaggaggtt	10	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:207169625C>G	uc002vbp.2	+	5	623	c.373C>G	c.(373-375)CAG>GAG	p.Q125E		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	125							nucleic acid binding|zinc ion binding			ovary(3)	3						TCATAAATCTCAGGAAGGCAC	0.468													0	0	0	1	0	9	27										G	207169625	C	G	207169625	3	3	65	1	0	0	0	0	1	0	0	0	17596	827	29	1	383	1	ZDBF2	2	207169625	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	287166	207169625	36029748	235	19268										
DYTN	391475	broad.mit.edu	37	chr2	207559580	207559580	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atctggcagatgtcaaagttGagacacttcagacagcggta	11	8	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:207559580G>C	uc002vbr.1	-	8	858	c.741C>G	c.(739-741)CTC>CTG	p.L247L		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	247	ZZ-type.					plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TGTCAAAGTTGAGACACTTCA	0.393													0	0	0	1	0	18	47										C	207559580	G	C	207559580	2	2	65	1	0	0	0	0	0	0	0	1	4861	1277	45	1		1	DYTN	2	207559580	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	389955	207559580	35639793	236	19269										
PIKFYVE	200576	broad.mit.edu	37	chr2	209203277	209203277	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaatatttctccaggacttCagaatggagaaaaaggttgg	12	5	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:209203277C>T	uc002vcz.2	+	29	4815	c.4657C>T	c.(4657-4659)CAG>TAG	p.Q1553*		NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1553					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TCCAGGACTTCAGAATGGAGA	0.348													0	0	0	1	0	8	35										T	209203277	C	T	209203277	4	4	65	1	0	0	0	0	0	1	0	0	11924	827	29	1	4778	1	PIKFYVE	2	209203277	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1643697	209203277	33996096	237	19270										
CPS1	1373	broad.mit.edu	37	chr2	211476905	211476905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttacggatgtgccacccatCtatagaaggtttcactcccc	7	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:211476905C>G	uc002vee.3	+	20	2588	c.2456C>G	c.(2455-2457)TCT>TGT	p.S819C	CPS1_uc010fur.2_Missense_Mutation_p.S825C|CPS1_uc010fus.2_Missense_Mutation_p.S368C	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	819					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGCCACCCATCTATAGAAGGT	0.413													0	0	0	1	0	34	89										G	211476905	C	G	211476905	3	3	65	1	0	0	0	0	1	0	0	0	3823	913	32	1	2556	1	CPS1	2	211476905	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2273628	211476905	31722468	238	19271										
CPS1	1373	broad.mit.edu	37	chr2	211513244	211513244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggactacccctgcttgttGaggccttcctatgttttgag	11	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:211513244G>C	uc002vee.3	+	27	3516	c.3384G>C	c.(3382-3384)TTG>TTC	p.L1128F	CPS1_uc010fur.2_Missense_Mutation_p.L1134F|CPS1_uc010fus.2_Missense_Mutation_p.L677F	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1128	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCTGCTTGTTGAGGCCTTCCT	0.333													0	0	0	1	0	21	79										C	211513244	G	C	211513244	3	2	65	1	0	0	0	0	1	0	0	0	3823	1281	45	1	3512	1	CPS1	2	211513244	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	36339	211513244	31686129	239	19272										
ABCA12	26154	broad.mit.edu	37	chr2	215875150	215875150	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcccaaatcacaggtccagCgggcatgttaatgatgtctt	10	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:215875150C>G	uc002vew.2	-	18	2597	c.2377G>C	c.(2377-2379)GCT>CCT	p.A793P	ABCA12_uc002vev.2_Missense_Mutation_p.A475P|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	793					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACAGGTCCAGCGGGCATGTTA	0.373													0	0	0	1	0	10	27										G	215875150	C	G	215875150	3	3	65	1	0	0	0	0	1	0	0	0	30	768	27	4	5554	4	ABCA12	2	215875150	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4361906	215875150	27324223	240	19273										
TNS1	7145	broad.mit.edu	37	chr2	218674590	218674590	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attccctgggcagagactttGaagtgaacgatggtggcagc	14	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:218674590G>C	uc002vgt.2	-	30	5315	c.4917C>G	c.(4915-4917)TTC>TTG	p.F1639L	TNS1_uc002vgr.2_Missense_Mutation_p.F1625L|TNS1_uc002vgs.2_Missense_Mutation_p.F1618L|TNS1_uc002vgq.2_Missense_Mutation_p.F139L	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1639						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CAGAGACTTTGAAGTGAACGA	0.552													0	0	0	1	0	13	43										C	218674590	G	C	218674590	3	2	65	1	0	0	0	0	1	0	0	0	16340	1281	45	1	306	1	TNS1	2	218674590	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2799440	218674590	24524783	241	19274										
ARPC2	10109	broad.mit.edu	37	chr2	219114098	219114098	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgccttcagtgctgttccctCgtcacaccaatgccagtgct	8	16	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:219114098C>T	uc002vhd.2	+	9	800	c.688C>T	c.(688-690)CGT>TGT	p.R230C	ARPC2_uc002vhe.2_Missense_Mutation_p.R230C|ARPC2_uc002vhf.2_Missense_Mutation_p.R116C	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	230					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		GCTGTTCCCTCGTCACACCAA	0.542													0	0	0	1	0	11	31										T	219114098	C	T	219114098	3	4	65	1	0	0	0	0	1	0	0	0	971	884	31	1	718	1	ARPC2	2	219114098	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	439508	219114098	24085275	242	19275										
NHEJ1	79840	broad.mit.edu	37	chr2	220022967	220022967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgccacacctgttgaagatCtgaaaccaacaaggcatagc	8	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:220022967C>T	uc002vjp.3	-	2	264	c.118G>A	c.(118-120)GAT>AAT	p.D40N	NHEJ1_uc002vjq.3_RNA	NM_024782	NP_079058	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	40					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		TGTTGAAGATCTGAAACCAAC	0.527								Direct_reversal_of_damage|NHEJ					0	0	0	1	0	31	121										T	220022967	C	T	220022967	3	4	65	1	0	0	0	0	1	0	0	0	10402	913	32	1	809	1	NHEJ1	2	220022967	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	908869	220022967	23176406	243	19276										
SLC23A3	151295	broad.mit.edu	37	chr2	220032963	220032963	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagtgtgagttgatgacgttGaagctcgcctccaggggcac	15	9	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:220032963G>C	uc010zks.1	-	6	863	c.752C>G	c.(751-753)TCA>TGA	p.S251*	NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Nonsense_Mutation_p.S259*|SLC23A3_uc010fwb.2_Missense_Mutation_p.Q241E|SLC23A3_uc002vjs.1_Missense_Mutation_p.F103L|SLC23A3_uc002vjt.1_Missense_Mutation_p.F110L	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	251	Extracellular (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGATGACGTTGAAGCTCGCCT	0.577													0	0	0	1	0	11	32										C	220032963	G	C	220032963	4	2	65	1	0	0	0	0	0	1	0	0	14464	1303	45	1	1108	1	SLC23A3	2	220032963	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9996	220032963	23166410	244	19277										
FAM134A	79137	broad.mit.edu	37	chr2	220046485	220046485	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccacaactccgcagctgactGatgtctccgagggtatgggg	13	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:220046485G>A	uc002vjw.3	+	8	1139	c.1003G>A	c.(1003-1005)GAT>AAT	p.D335N	FAM134A_uc010fwc.2_Missense_Mutation_p.D128N|FAM134A_uc002vjx.2_Missense_Mutation_p.D128N	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	335						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGCTGACTGATGTCTCCGA	0.577													0	0	0	1	0	21	88										A	220046485	G	A	220046485	3	1	65	1	0	0	0	0	1	0	0	0	5445	1290	45	1	1033	1	FAM134A	2	220046485	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13522	220046485	23152888	245	19278										
ATG9A	79065	broad.mit.edu	37	chr2	220085587	220085587	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaggcagccgagagaaatgaGagggaaccctgggcactgtg	17	8	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:220085587G>C	uc002vke.1	-	15	2582	c.2396C>G	c.(2395-2397)TCT>TGT	p.S799C	ABCB6_uc002vkc.1_5'Flank|ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Missense_Mutation_p.S799C	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	799	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAGAAATGAGAGGGAACCCT	0.577													0	0	0	1	0	19	64										C	220085587	G	C	220085587	3	2	65	1	0	0	0	0	1	0	0	0	1102	942	33	1	131	1	ATG9A	2	220085587	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	39102	220085587	23113786	246	19279										
STK11IP	114790	broad.mit.edu	37	chr2	220474164	220474164	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagggacctcctgctgggtaGattccagtgtctacgctgtg	13	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:220474164G>A	uc002vml.2	+	17	2082	c.2039G>A	c.(2038-2040)AGA>AAA	p.R680K	STK11IP_uc010zll.1_3'UTR|STK11IP_uc002vmm.1_Missense_Mutation_p.R669K	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	680					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGCTGGGTAGATTCCAGTGT	0.582													0	0	0	1	0	5	20										A	220474164	G	A	220474164	3	1	65	1	0	0	0	0	1	0	0	0	15287	942	33	1	2105	1	STK11IP	2	220474164	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	388577	220474164	22725209	247	19280										
SLC4A3	6508	broad.mit.edu	37	chr2	220502408	220502408	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagtgccctgccccccaccGagggcccccccagcccgagg	12	22	0	0	rs140581019	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:220502408G>A	uc002vmp.3	+	17	2910	c.2641G>A	c.(2641-2643)GAG>AAG	p.E881K	SLC4A3_uc002vmo.3_Missense_Mutation_p.E908K|SLC4A3_uc010fwm.2_Missense_Mutation_p.E431K|SLC4A3_uc010fwn.1_Missense_Mutation_p.E390K	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	881	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCCCCCACCGAGGGCCCCCC	0.647													0	0	0	1	0	23	77										A	220502408	G	A	220502408	3	1	65	1	0	0	0	0	1	0	0	0	14655	1059	37	1	2784	1	SLC4A3	2	220502408	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	28244	220502408	22696965	248	19281										
CCDC140	151278	broad.mit.edu	37	chr2	223169063	223169063	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagatgaaaaagaagaaaGagagaaagagaagaaaagag	14	0	0	9			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:223169063G>A	uc002vnb.1	+	2	826	c.442G>A	c.(442-444)GAG>AAG	p.E148K		NM_153038	NP_694583	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	148	Potential.										0		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		aaagaagaaagagagaaagag	0.403													0	0	0	1	0	5	26										A	223169063	G	A	223169063	3	1	65	1	0	0	0	0	1	0	0	0	2774	943	33	1	444	1	CCDC140	2	223169063	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2666655	223169063	20030310	249	19282										
DOCK10	55619	broad.mit.edu	37	chr2	225666692	225666692	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagaaagtgcatttttgcctCgaattataggtaaagtttgt	9	4	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:225666692C>T	uc010fwz.1	-	40	4573	c.4334G>A	c.(4333-4335)CGA>CAA	p.R1445Q	DOCK10_uc002vob.2_Missense_Mutation_p.R1439Q|DOCK10_uc002voa.2_Missense_Mutation_p.R101Q|DOCK10_uc002voc.2_Missense_Mutation_p.R299Q	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1445							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ATTTTTGCCTCGAATTATAGG	0.368													0	0	0	1	0	17	62										T	225666692	C	T	225666692	3	4	65	1	0	0	0	0	1	0	0	0	4685	884	31	1	2294	1	DOCK10	2	225666692	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2497629	225666692	17532681	250	19283										
COL4A4	1286	broad.mit.edu	37	chr2	227898175	227898175	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcaatccatgcaagccgttCaggccaggtgatccggaggg	13	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:227898175C>G	uc010zlt.1	-	38	4182	c.3528G>C	c.(3526-3528)CTG>CTC	p.L1176L		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1176	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCAAGCCGTTCAGGCCAGGTG	0.522											OREG0015250	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	48										G	227898175	C	G	227898175	2	3	65	1	0	0	0	0	0	0	0	1	3693	813	29	1		1	COL4A4	2	227898175	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2231483	227898175	15301198	251	19284										
TRIP12	9320	broad.mit.edu	37	chr2	230723619	230723619	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcccaatcaaattttgaaGagccaccagttttactctgt	6	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:230723619G>A	uc002vpw.1	-	3	879	c.770C>T	c.(769-771)TCT>TTT	p.S257F	TRIP12_uc002vpx.1_Missense_Mutation_p.S299F|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Missense_Mutation_p.S257F	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	257					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		AAATTTTGAAGAGCCACCAGT	0.473													0	0	0	1	0	21	67										A	230723619	G	A	230723619	3	1	65	1	0	0	0	0	1	0	0	0	16553	942	33	1	5364	1	TRIP12	2	230723619	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2825444	230723619	12475754	252	19285										
SP100	6672	broad.mit.edu	37	chr2	231379918	231379918	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctaaagagaaaggaaaatttGaagatatggcaaaggcggac	12	4	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:231379918G>A	uc002vqt.2	+	25	2344	c.2203G>A	c.(2203-2205)GAA>AAA	p.E735K	SP100_uc002vqu.1_Intron|SP100_uc010fxp.1_Intron	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	735	HMG box 1.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGGAAAATTTGAAGATATGGC	0.388													0	0	0	1	0	23	73										A	231379918	G	A	231379918	3	1	65	1	0	0	0	0	1	0	0	0	14960	1291	45	1	2301	1	SP100	2	231379918	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	656299	231379918	11819455	253	19286										
ARMC9	80210	broad.mit.edu	37	chr2	232100023	232100023	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtacaataagatccaggccGactaccacaatctcattgga	8	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:232100023G>A	uc002vrq.3	+	8	821	c.709G>A	c.(709-711)GAC>AAC	p.D237N	ARMC9_uc002vrp.3_Missense_Mutation_p.D237N	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	237							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GATCCAGGCCGACTACCACAA	0.488													0	0	0	1	0	11	40										A	232100023	G	A	232100023	3	1	65	1	0	0	0	0	1	0	0	0	958	1058	37	1	735	1	ARMC9	2	232100023	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	720105	232100023	11099350	254	19287										
ARMC9	80210	broad.mit.edu	37	chr2	232143143	232143143	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctcgtgctcaaagtcctttCggatcttcttggccatgaaa	8	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:232143143C>A	uc002vrq.3	+	16	1635	c.1523C>A	c.(1522-1524)TCG>TAG	p.S508*	ARMC9_uc002vrp.3_Nonsense_Mutation_p.S508*|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	508							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		AAAGTCCTTTCGGATCTTCTT	0.507													1	0	2.95478e-19	1	3.13632e-19	40	106										A	232143143	C	A	232143143	4	1	65	1	0	0	0	0	0	1	0	0	958	893	31	3	1581	3	ARMC9	2	232143143	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	43120	232143143	11056230	255	19288										
DGKD	8527	broad.mit.edu	37	chr2	234343511	234343511	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaatgtgtgccgtgaggctCtgtctggggtcacgtcgcac	15	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:234343511C>G	uc002vui.1	+	5	562	c.550C>G	c.(550-552)CTG>GTG	p.L184V	DGKD_uc002vuj.1_Missense_Mutation_p.L140V|DGKD_uc010fyh.1_Missense_Mutation_p.L51V|DGKD_uc002vuk.1_Missense_Mutation_p.L51V	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	184	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CCGTGAGGCTCTGTCTGGGGT	0.567													0	0	0	1	0	48	163										G	234343511	C	G	234343511	3	3	65	1	0	0	0	0	1	0	0	0	4467	912	32	1	592	1	DGKD	2	234343511	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2200368	234343511	8855862	256	19289										
UGT1A5	54579	broad.mit.edu	37	chr2	234621763	234621763	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actgatggcagccactggctCagcatgcgggaggccttgcg	15	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:234621763C>G	uc002vuw.2	+	1	126	c.126C>G	c.(124-126)CTC>CTG	p.L42L	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Silent_p.L42L	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	42					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		GCCACTGGCTCAGCATGCGGG	0.602													0	0	0	1	0	17	72										G	234621763	C	G	234621763	2	3	65	1	0	0	0	0	0	0	0	1	16945	813	29	1		1	UGT1A5	2	234621763	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	278252	234621763	8577610	257	19290										
ARL4C	10123	broad.mit.edu	37	chr2	235404739	235404739	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccctcggtgaggccctcgccGatgatggcgcacgccggctg	15	16	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:235404739G>A	uc002vvn.2	-	1	955	c.492C>T	c.(490-492)ATC>ATT	p.I164I	ARL4C_uc002vvm.3_Silent_p.I164I	NM_005737	NP_005728	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	164					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			skin(1)	1		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		GGCCCTCGCCGATGATGGCGC	0.617													0	0	0	1	0	18	57										A	235404739	G	A	235404739	2	1	65	1	0	0	0	0	0	0	0	1	937	1048	37	1		1	ARL4C	2	235404739	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	782976	235404739	7794634	258	19291										
SH3BP4	23677	broad.mit.edu	37	chr2	235962340	235962340	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacctgggcctggacaagatGaaaaaccccatcaccaagcg	9	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:235962340G>A	uc002vvp.2	+	6	3165	c.2772G>A	c.(2770-2772)ATG>ATA	p.M924I	SH3BP4_uc010fym.2_Missense_Mutation_p.M906I|SH3BP4_uc002vvq.2_Missense_Mutation_p.M924I	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	924					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TGGACAAGATGAAAAACCCCA	0.582													0	0	0	1	0	49	153										A	235962340	G	A	235962340	3	1	65	1	0	0	0	0	1	0	0	0	14246	1290	45	1	2786	1	SH3BP4	2	235962340	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	557601	235962340	7237033	259	19292										
OR6B3	150681	broad.mit.edu	37	chr2	240984886	240984886	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caccaggatgatgaaggccaGaatgaaatccaccagctctg	10	11	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:240984886G>C	uc010zoe.1	-	1	604	c.604C>G	c.(604-606)CTG>GTG	p.L202V	PRR21_uc010zod.1_5'Flank	NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		ATGAAGGCCAGAATGAAATCC	0.577													0	0	0	1	0	15	71										C	240984886	G	C	240984886	3	2	65	1	0	0	0	0	1	0	0	0	11189	933	33	1	394	1	OR6B3	2	240984886	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5022546	240984886	2214487	260	19293										
ATG4B	23192	broad.mit.edu	37	chr2	242594013	242594013	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacagctacttcagcgtcctCaacgcattcatcgacaggaa	8	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr2:242594013C>G	uc002wbv.2	+	5	439	c.336C>G	c.(334-336)CTC>CTG	p.L112L	ATG4B_uc002wbu.2_Silent_p.L38L|ATG4B_uc002wbw.2_Silent_p.L112L|ATG4B_uc010zox.1_Silent_p.L98L|ATG4B_uc010zoy.1_Silent_p.L38L|ATG4B_uc010fzp.2_Silent_p.L112L|ATG4B_uc010zoz.1_Silent_p.L38L	NM_013325	NP_037457	Q9Y4P1	ATG4B_HUMAN	APG4 autophagy 4 homolog B isoform a	112					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		TCAGCGTCCTCAACGCATTCA	0.502													0	0	0	1	0	5	10										G	242594013	C	G	242594013	2	3	65	1	0	0	0	0	0	0	0	1	1097	813	29	1		1	ATG4B	2	242594013	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1609127	242594013	605360	261	19294										
CPNE9	151835	broad.mit.edu	37	chr3	9754751	9754751	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtgcgggctctgtgcaatgGagactatgacaggttggctc	15	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:9754751G>A	uc003bsd.2	+	9	809	c.638G>A	c.(637-639)GGA>GAA	p.G213E		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	213	C2 2.									ovary(2)	2	Medulloblastoma(99;0.227)					CTGTGCAATGGAGACTATGAC	0.527													0	0	0	1	0	11	33										A	9754751	G	A	9754751	3	1	65	1	0	0	0	0	1	0	0	0	3819	1174	41	1	672	1	CPNE9	3	9754751	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		9754751	188267679	262	19295										
TTLL3	26140	broad.mit.edu	37	chr3	9843424	9843424	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agagaacttctttatccttcGaaggaagcctgtggaggtga	12	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:9843424G>A	uc003btd.3	+	3	311	c.32G>A	c.(31-33)CGA>CAA	p.R11Q	ARPC4_uc003bsz.1_Missense_Mutation_p.R105Q|ARPC4_uc003bta.1_Missense_Mutation_p.R15Q|ARPC4_uc003btb.1_Missense_Mutation_p.R15Q|ARPC4_uc003btc.1_Intron			Q9Y4R7	TTLL3_HUMAN	RecName: Full=Tubulin--tyrosine ligase-like protein 3; AltName: Full=HOTTL;	11					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					TTTATCCTTCGAAGGAAGCCT	0.498													0	0	0	1	0	3	20										A	9843424	G	A	9843424	3	1	65	1	0	0	0	0	1	0	0	0	16725	1058	37	1		1	TTLL3	3	9843424	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	88673	9843424	188179006	263	19296										
PRRT3	285368	broad.mit.edu	37	chr3	9988025	9988025	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagaatcaggggctggggtCggggcaggcagtagctgtac	19	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:9988025C>T	uc003bul.2	-	4	2962	c.2832G>A	c.(2830-2832)CCG>CCA	p.P944P	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	944	Cytoplasmic (Potential).					integral to membrane					0						GGGCTGGGGTCGGGGCAGGCA	0.662													0	0	0	1	0	20	49										T	9988025	C	T	9988025	2	4	65	1	0	0	0	0	0	0	0	1	12611	871	31	1		1	PRRT3	3	9988025	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	144601	9988025	188034405	264	19297										
ATP2B2	491	broad.mit.edu	37	chr3	10382201	10382201	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atggcaaaggtgcccagcacGatggtgcagaagatggggtt	16	7	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:10382201G>A	uc003bvt.2	-	20	3544	c.3105C>T	c.(3103-3105)ATC>ATT	p.I1035I	ATP2B2_uc003bvv.2_Silent_p.I990I|ATP2B2_uc003bvw.2_Silent_p.I990I|ATP2B2_uc010hdo.2_Silent_p.I740I	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1035	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TGCCCAGCACGATGGTGCAGA	0.627													0	0	0	1	0	41	116										A	10382201	G	A	10382201	2	1	65	1	0	0	0	0	0	0	0	1	1140	1048	37	1		1	ATP2B2	3	10382201	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	394176	10382201	187640229	265	19298										
SLC6A1	6529	broad.mit.edu	37	chr3	11058933	11058933	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcaaggtggccgacgggcaGatctccaccgaggtcagcga	15	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:11058933G>T	uc010hdq.2	+	3	447	c.36G>T	c.(34-36)CAG>CAT	p.Q12H		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	12	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCGACGGGCAGATCTCCACCG	0.642													1	0	5.35356e-11	1	5.5948e-11	23	68										T	11058933	G	T	11058933	3	4	65	1	0	0	0	0	1	0	0	0	14673	933	33	3	38	3	SLC6A1	3	11058933	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	676732	11058933	186963497	266	19299										
NUP210	23225	broad.mit.edu	37	chr3	13383323	13383323	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagttagactggtctggccGatggccacaccgcggatgag	15	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:13383323G>A	uc003bxv.1	-	23	3236	c.3153C>T	c.(3151-3153)ATC>ATT	p.I1051I		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1051	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TGGTCTGGCCGATGGCCACAC	0.522													0	0	0	1	0	14	50										A	13383323	G	A	13383323	2	1	65	1	0	0	0	0	0	0	0	1	10760	1048	37	1		1	NUP210	3	13383323	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2324390	13383323	184639107	267	19300										
ZNF385D	79750	broad.mit.edu	37	chr3	21462822	21462822	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgttgctgctggagcagttcGaagactgaagggggaactca	15	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:21462822G>A	uc003cce.2	-	8	1480	c.1072C>T	c.(1072-1074)CGA>TGA	p.R358*		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	358						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGAGCAGTTCGAAGACTGAAG	0.473													0	0	0	1	0	16	30										A	21462822	G	A	21462822	4	1	65	1	0	0	0	0	0	1	0	0	17875	1066	37	1	119	1	ZNF385D	3	21462822	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8079499	21462822	176559608	268	19301										
RARB	5915	broad.mit.edu	37	chr3	25611305	25611305	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttcgaagcaagaatgcacaGagagctatgaaatgacagct	10	8	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:25611305G>A	uc011awl.1	+	4	592	c.526G>A	c.(526-528)GAG>AAG	p.E176K	RARB_uc003cdi.1_Missense_Mutation_p.E57K|RARB_uc003cdh.2_Missense_Mutation_p.E169K	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	176	Hinge.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AGAATGCACAGAGAGCTATGA	0.488													0	0	0	1	0	29	89										A	25611305	G	A	25611305	3	1	65	1	0	0	0	0	1	0	0	0	13053	943	33	1	519	1	RARB	3	25611305	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4148483	25611305	172411125	269	19302										
NGLY1	55768	broad.mit.edu	37	chr3	25773930	25773930	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaagctccacaattatcctCtggagaagttctttccttct	5	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:25773930C>T	uc003cdl.2	-	9	1413	c.1305G>A	c.(1303-1305)CAG>CAA	p.Q435Q	NGLY1_uc010hfg.2_Silent_p.Q417Q|NGLY1_uc003cdm.2_Silent_p.Q435Q|NGLY1_uc011awo.1_Silent_p.Q393Q|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	435					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						CAATTATCCTCTGGAGAAGTT	0.398													0	0	0	1	0	20	48										T	25773930	C	T	25773930	2	4	65	1	0	0	0	0	0	0	0	1	10398	912	32	1		1	NGLY1	3	25773930	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	162625	25773930	172248500	270	19303										
GADL1	339896	broad.mit.edu	37	chr3	30880497	30880497	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaatgaacttacatctacatGaagccagaggctgtgcctct	8	10	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:30880497G>A	uc003cep.2	-	9	942	c.895C>T	c.(895-897)CAT>TAT	p.H299Y	GADL1_uc003ceq.1_Missense_Mutation_p.H299Y	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	299					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	ACATCTACATGAAGCCAGAGG	0.418													0	0	0	1	0	4	65										A	30880497	G	A	30880497	3	1	65	1	0	0	0	0	1	0	0	0	6185	1290	45	1	698	1	GADL1	3	30880497	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5106567	30880497	167141933	271	19304										
CCR4	1233	broad.mit.edu	37	chr3	32995455	32995455	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgttcagcacttgttatactGagcgcaaccatacctactgc	7	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:32995455G>A	uc003cfg.1	+	2	709	c.541G>A	c.(541-543)GAG>AAG	p.E181K		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	181	Extracellular (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						TTGTTATACTGAGCGCAACCA	0.507													0	0	0	1	0	28	92										A	32995455	G	A	32995455	3	1	65	1	0	0	0	0	1	0	0	0	2943	1291	45	1	543	1	CCR4	3	32995455	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2114958	32995455	165026975	272	19305										
STAC	6769	broad.mit.edu	37	chr3	36587730	36587730	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatggttttatcagagtcctCagtggaaaaaagaaaggcct	11	6	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:36587730C>T	uc003cgh.1	+	11	1197	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	STAC_uc011aya.1_Silent_p.L325L	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	386					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						TCAGAGTCCTCAGTGGAAAAA	0.438													0	0	0	1	0	29	88										T	36587730	C	T	36587730	2	4	65	1	0	0	0	0	0	0	0	1	15238	813	29	1		1	STAC	3	36587730	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3592275	36587730	161434700	273	19306										
TRANK1	9881	broad.mit.edu	37	chr3	36897001	36897001	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcttcatcaaaataacctttCtgggacctgatttgctgata	6	9	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:36897001C>A	uc003cgj.2	-	3	2732	c.2430G>T	c.(2428-2430)CAG>CAT	p.Q810H		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1360					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AATAACCTTTCTGGGACCTGA	0.473													1	0	1.39193e-11	1	1.45645e-11	51	131										A	36897001	C	A	36897001	3	1	65	1	0	0	0	0	1	0	0	0	16451	912	32	3	4745	3	TRANK1	3	36897001	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	309271	36897001	161125429	274	19307										
TRANK1	9881	broad.mit.edu	37	chr3	36897398	36897398	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagaccatcctatgatggttCttttcaagcttccatcttcg	6	12	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:36897398C>G	uc003cgj.2	-	3	2335	c.2033G>C	c.(2032-2034)AGA>ACA	p.R678T		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1228					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TATGATGGTTCTTTTCAAGCT	0.468													0	0	0	1	0	52	101										G	36897398	C	G	36897398	3	3	65	1	0	0	0	0	1	0	0	0	16451	913	32	1	5142	1	TRANK1	3	36897398	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	397	36897398	161125032	275	19308										
LRRFIP2	9209	broad.mit.edu	37	chr3	37107346	37107346	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caagacctgagcagcttcctGagacacaacagtgatggctc	10	12	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:37107346G>C	uc003cgp.2	-	24	2077	c.1654C>G	c.(1654-1656)CAG>GAG	p.Q552E	MLH1_uc011aye.1_3'UTR|LRRFIP2_uc011ayf.1_Missense_Mutation_p.Q334E|LRRFIP2_uc003cgr.2_Missense_Mutation_p.Q255E|LRRFIP2_uc003cgs.3_Missense_Mutation_p.Q255E|LRRFIP2_uc003cgt.3_Missense_Mutation_p.Q231E	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	552					Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						GCAGCTTCCTGAGACACAACA	0.483													0	0	0	1	0	27	84										C	37107346	G	C	37107346	3	2	65	1	0	0	0	0	1	0	0	0	9028	1299	45	1	535	1	LRRFIP2	3	37107346	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	209948	37107346	160915084	276	19309										
DLEC1	9940	broad.mit.edu	37	chr3	38158112	38158112	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctctggtccccaggcccctCcagttcatcggaattcagcc	8	18	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:38158112C>T	uc003cho.1	+	28	4046	c.4025C>T	c.(4024-4026)TCC>TTC	p.S1342F	DLEC1_uc003chp.1_Missense_Mutation_p.S1342F|DLEC1_uc010hgv.1_Missense_Mutation_p.S1345F|DLEC1_uc003chr.1_Missense_Mutation_p.S413F|DLEC1_uc010hgx.1_RNA|DLEC1_uc003chs.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1342					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CCAGGCCCCTCCAGTTCATCG	0.627													0	0	0	1	0	35	99										T	38158112	C	T	38158112	3	4	65	1	0	0	0	0	1	0	0	0	4552	855	30	1	4135	1	DLEC1	3	38158112	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1050766	38158112	159864318	277	19310										
ACAA1	30	broad.mit.edu	37	chr3	38168124	38168124	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctcttggtgcccttgtcatCatggaccgtggtggtcacag	12	12	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:38168124C>T	uc003cht.2	-	8	901	c.694G>A	c.(694-696)GAT>AAT	p.D232N	ACAA1_uc003chu.2_Missense_Mutation_p.D199N|ACAA1_uc010hgy.2_Missense_Mutation_p.D191N|ACAA1_uc010hgz.2_Missense_Mutation_p.D232N|ACAA1_uc003chv.2_Missense_Mutation_p.D80N	NM_001607	NP_001598	P09110	THIK_HUMAN	acetyl-Coenzyme A acyltransferase 1 isoform a	232					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		CCCTTGTCATCATGGACCGTG	0.592													0	0	0	1	0	30	93										T	38168124	C	T	38168124	3	4	65	1	0	0	0	0	1	0	0	0	104	826	29	1	600	1	ACAA1	3	38168124	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	10012	38168124	159854306	278	19311										
XYLB	9942	broad.mit.edu	37	chr3	38404477	38404477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcttcgggcttcgacttctCtcaagtcctagccttgtccg	10	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:38404477C>T	uc003cic.2	+	4	369	c.260C>T	c.(259-261)TCT>TTT	p.S87F	XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_Missense_Mutation_p.S9F	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	87					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TTCGACTTCTCTCAAGTCCTA	0.522													0	0	0	1	0	20	90										T	38404477	C	T	38404477	3	4	65	1	0	0	0	0	1	0	0	0	17459	913	32	1	274	1	XYLB	3	38404477	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	236353	38404477	159617953	279	19312										
ZNF619	285267	broad.mit.edu	37	chr3	40529228	40529228	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatgaatgttggaaaactttCagctgtagctcccgcttcat	8	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:40529228C>T	uc011azb.1	+	6	1625	c.1347C>T	c.(1345-1347)TTC>TTT	p.F449F	ZNF619_uc010hhz.2_Silent_p.F400F|ZNF619_uc003ckj.2_Silent_p.F393F|ZNF619_uc011azc.1_Silent_p.F409F|ZNF619_uc011azd.1_Silent_p.F365F|ZNF619_uc011aza.1_Silent_p.F351F	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	449					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GGAAAACTTTCAGCTGTAGCT	0.468													0	0	0	1	0	21	79										T	40529228	C	T	40529228	2	4	65	1	0	0	0	0	0	0	0	1	18040	825	29	1		1	ZNF619	3	40529228	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2124751	40529228	157493202	280	19313										
C3orf23	285343	broad.mit.edu	37	chr3	44442825	44442825	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaacatgaaaagaaaggaaGagtaagtactgccagtcttc	10	6	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:44442825G>C	uc010him.2	+	10	1494	c.1249G>C	c.(1249-1251)GAG>CAG	p.E417Q	C3orf23_uc003cnd.3_Missense_Mutation_p.E417Q|C3orf23_uc003cne.3_Missense_Mutation_p.E273Q	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	417	Potential.					mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		AAGAAAGGAAGAGTAAGTACT	0.398													0	0	0	1	0	19	55										C	44442825	G	C	44442825	3	2	65	1	0	0	0	0	1	0	0	0	2216	956	33	1	1335	1	C3orf23	3	44442825	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3913597	44442825	153579605	281	19314										
CDCP1	64866	broad.mit.edu	37	chr3	45153662	45153662	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taaggccattttcactccttCttgcatcttgatccgggaca	7	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:45153662C>G	uc003com.2	-	3	703	c.568G>C	c.(568-570)GAA>CAA	p.E190Q	CDCP1_uc003con.2_Missense_Mutation_p.E190Q	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	190	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TTCACTCCTTCTTGCATCTTG	0.537													0	0	0	1	0	41	104										G	45153662	C	G	45153662	3	3	65	1	0	0	0	0	1	0	0	0	3093	922	32	1	1978	1	CDCP1	3	45153662	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	710837	45153662	152868768	282	19315										
CCR2	729230	broad.mit.edu	37	chr3	46399402	46399402	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcggttattttggcggaatCttcttcatcatcctcctgac	7	11	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:46399402C>T	uc003cpn.3	+	2	869	c.384C>T	c.(382-384)ATC>ATT	p.I128I	CCR2_uc003cpm.3_Silent_p.I128I	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	128	Helical; Name=3; (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		TTGGCGGAATCTTCTTCATCA	0.468													0	0	0	1	0	76	274										T	46399402	C	T	46399402	2	4	65	1	0	0	0	0	0	0	0	1	2941	903	32	1		1	CCR2	3	46399402	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1245740	46399402	151623028	283	19316										
LTF	4057	broad.mit.edu	37	chr3	46492002	46492002	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacctgtgcctggcggagaaGattccagatggcatcctcct	11	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:46492002G>A	uc003cpq.2	-	7	903	c.865C>T	c.(865-867)CTT>TTT	p.L289F	LTF_uc003fzr.2_Missense_Mutation_p.L245F|LTF_uc010hjh.2_Missense_Mutation_p.L289F|LTF_uc003cpr.2_Missense_Mutation_p.L276F	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	289	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	TGGCGGAGAAGATTCCAGATG	0.562													0	0	0	1	0	9	27										A	46492002	G	A	46492002	3	1	65	1	0	0	0	0	1	0	0	0	9079	942	33	1	1311	1	LTF	3	46492002	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	92600	46492002	151530428	284	19317										
PRSS50	29122	broad.mit.edu	37	chr3	46753882	46753882	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taggtagatgggtggggcctCgctcttctggcagcctgcac	15	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:46753882C>T	uc003cqe.1	-	6	1071	c.1012G>A	c.(1012-1014)GAG>AAG	p.E338K	PRSS50_uc003cqf.1_Missense_Mutation_p.E252K	NM_013270	NP_037402	Q9UI38	TSP50_HUMAN	testes-specific protease 50 precursor	338	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity				0						GGTGGGGCCTCGCTCTTCTGG	0.637													0	0	0	1	0	15	48										T	46753882	C	T	46753882	3	4	65	1	0	0	0	0	1	0	0	0	12631	893	31	1	149	1	PRSS50	3	46753882	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	261880	46753882	151268548	285	19318										
KLHL18	23276	broad.mit.edu	37	chr3	47384267	47384267	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgctggggttacagtctttGagggcaggatatatgtgtca	14	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:47384267G>C	uc003crd.2	+	9	1411	c.1285G>C	c.(1285-1287)GAG>CAG	p.E429Q	KLHL18_uc011bav.1_Missense_Mutation_p.E317Q	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	429	Kelch 3.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		TACAGTCTTTGAGGGCAGGAT	0.512													0	0	0	1	0	22	53										C	47384267	G	C	47384267	3	2	65	1	0	0	0	0	1	0	0	0	8373	1291	45	1	1319	1	KLHL18	3	47384267	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	630385	47384267	150638163	286	19319										
DHX30	22907	broad.mit.edu	37	chr3	47868907	47868907	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtgtgattggaagagccctCggcatctcacatgcaaaaga	11	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:47868907C>T	uc003cru.2	+	5	621	c.195C>T	c.(193-195)CTC>CTT	p.L65L	DHX30_uc003crs.2_Silent_p.L26L|DHX30_uc003crt.2_Silent_p.L26L|DHX30_uc010hjr.1_Silent_p.L93L	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	65	DRBM.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GAAGAGCCCTCGGCATCTCAC	0.418													0	0	0	1	0	23	59										T	47868907	C	T	47868907	2	4	65	1	0	0	0	0	0	0	0	1	4504	871	31	1		1	DHX30	3	47868907	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	484640	47868907	150153523	287	19320										
COL7A1	1294	broad.mit.edu	37	chr3	48603971	48603971	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcttctcccttctcgcctCgaggaccggcaggccctggc	11	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:48603971C>G	uc003ctz.2	-	112	8331	c.8330G>C	c.(8329-8331)CGA>CCA	p.R2777P	UCN2_uc003cty.1_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2777	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTTCTCGCCTCGAGGACCGGC	0.473													0	0	0	1	0	44	142										G	48603971	C	G	48603971	3	3	65	1	0	0	0	0	1	0	0	0	3704	884	31	1	532	1	COL7A1	3	48603971	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	735064	48603971	149418459	288	19321										
COL7A1	1294	broad.mit.edu	37	chr3	48613150	48613150	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agctaccagagctctcatccCaggtctccacgatctcccgc	7	18	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:48613150C>G	uc003ctz.2	-	72	5889	c.5888G>C	c.(5887-5889)TGG>TCG	p.W1963S		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1963	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCTCTCATCCCAGGTCTCCAC	0.667													0	0	0	1	0	20	89										G	48613150	C	G	48613150	3	3	65	1	0	0	0	0	1	0	0	0	3704	595	21	4	3134	4	COL7A1	3	48613150	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	9179	48613150	149409280	289	19322										
PRKAR2A	5576	broad.mit.edu	37	chr3	48884791	48884791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccaagtcctcgtcctcctccGactcgctgtcccctttggcg	8	19	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:48884791G>A	uc010hki.1	-	1	480	c.239C>T	c.(238-240)TCG>TTG	p.S80L	PRKAR2A_uc003cux.1_Missense_Mutation_p.S80L|PRKAR2A_uc003cuy.1_Missense_Mutation_p.S80L|uc003cuz.1_5'Flank	NM_004157	NP_004148	P13861	KAP2_HUMAN	cAMP-dependent protein kinase, regulatory	80	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		GTCCTCCTCCGACTCGCTGTC	0.716													0	0	0	1	0	14	27										A	48884791	G	A	48884791	3	1	65	1	0	0	0	0	1	0	0	0	12505	1059	37	1	1019	1	PRKAR2A	3	48884791	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	271641	48884791	149137639	290	19323										
PRKAR2A	5576	broad.mit.edu	37	chr3	48884887	48884887	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggtggcggcgggcaggactGaggctggggcgcgggcctcg	24	10	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:48884887G>C	uc010hki.1	-	1	384	c.143C>G	c.(142-144)TCA>TGA	p.S48*	PRKAR2A_uc003cux.1_Nonsense_Mutation_p.S48*|PRKAR2A_uc003cuy.1_Nonsense_Mutation_p.S48*|uc003cuz.1_5'Flank	NM_004157	NP_004148	P13861	KAP2_HUMAN	cAMP-dependent protein kinase, regulatory	48	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		GGGCAGGACTGAGGCTGGGGC	0.726													0	0	0	1	0	6	11										C	48884887	G	C	48884887	4	2	65	1	0	0	0	0	0	1	0	0	12505	1294	45	1	1115	1	PRKAR2A	3	48884887	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	96	48884887	149137543	291	19324										
P4HTM	54681	broad.mit.edu	37	chr3	49027929	49027929	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacgtgctggcgctgctgctCttcgtgcactacagcaacgg	12	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:49027929C>G	uc003cvg.2	+	1	589	c.240C>G	c.(238-240)CTC>CTG	p.L80L	P4HTM_uc003cvh.2_Silent_p.L80L	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	80	Helical; Signal-anchor for type II membrane protein; (Potential).					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	CGCTGCTGCTCTTCGTGCACT	0.682													0	0	0	1	0	14	33										G	49027929	C	G	49027929	2	3	65	1	0	0	0	0	0	0	0	1	11360	900	32	1		1	P4HTM	3	49027929	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	143042	49027929	148994501	292	19325										
WDR6	11180	broad.mit.edu	37	chr3	49050213	49050213	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctatggccaatggggaaggtCgtgtcaaggttgtccccatc	13	10	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:49050213C>T	uc003cvj.2	+	2	1474	c.1336C>T	c.(1336-1338)CGT>TGT	p.R446C	WDR6_uc011bbx.1_Missense_Mutation_p.R317C|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Missense_Mutation_p.R390C|WDR6_uc011bbz.1_Missense_Mutation_p.R365C	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	416					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGGGGAAGGTCGTGTCAAGGT	0.572													0	0	0	1	0	10	49										T	49050213	C	T	49050213	3	4	65	1	0	0	0	0	1	0	0	0	17307	884	31	1	1342	1	WDR6	3	49050213	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	22284	49050213	148972217	293	19326										
LAMB2	3913	broad.mit.edu	37	chr3	49160696	49160696	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagtgcctctgtccgatgccGagcacttgccgagttgctca	11	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:49160696G>A	uc003cwe.2	-	26	4392	c.4093C>T	c.(4093-4095)CGG>TGG	p.R1365W	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1365	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTCCGATGCCGAGCACTTGCC	0.587													0	0	0	1	0	41	124										A	49160696	G	A	49160696	3	1	65	1	0	0	0	0	1	0	0	0	8611	1057	37	1	1331	1	LAMB2	3	49160696	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	110483	49160696	148861734	294	19327										
KLHDC8B	200942	broad.mit.edu	37	chr3	49212219	49212219	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgactgcttttgaagcctttGatctggaggcccgtacatgg	12	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:49212219G>C	uc003cwh.2	+	4	771	c.586G>C	c.(586-588)GAT>CAT	p.D196H	KLHDC8B_uc003cwi.1_Missense_Mutation_p.D69H	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	196	Kelch 5.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGAAGCCTTTGATCTGGAGGC	0.632													0	0	0	1	0	22	58										C	49212219	G	C	49212219	3	2	65	1	0	0	0	0	1	0	0	0	8363	1290	45	1	596	1	KLHDC8B	3	49212219	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	51523	49212219	148810211	295	19328										
DAG1	1605	broad.mit.edu	37	chr3	49569108	49569108	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctaggccccatccagcctacTcgggtgtcagaagctggcac	11	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:49569108T>C	uc003cxc.3	+	3	1582	c.1164T>C	c.(1162-1164)ACT>ACC	p.T388T		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	388	Thr-rich.|Required for laminin recognition.|Mucin-like domain.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		TCCAGCCTACTCGGGTGTCAG	0.587													0	0	0	1	0	59	152										C	49569108	T	C	49569108	2	2	65	1	0	0	0	0	0	0	0	1	4225	1538	54	5		5	DAG1	3	49569108	Silent	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	356889	49569108	148453322	296	19329										
IP6K1	9807	broad.mit.edu	37	chr3	49770264	49770264	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gactcggagcgcatgcggctCagctgctgcttgtgacaacg	14	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:49770264C>G	uc003cxm.1	-	4	891	c.576G>C	c.(574-576)CTG>CTC	p.L192L	IP6K1_uc003cxn.1_Silent_p.L27L|IP6K1_uc011bcv.1_Silent_p.L27L|IP6K1_uc003cxo.2_Silent_p.L192L	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	192					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						GCATGCGGCTCAGCTGCTGCT	0.567													0	0	0	1	0	25	53										G	49770264	C	G	49770264	2	3	65	1	0	0	0	0	0	0	0	1	7788	813	29	1		1	IP6K1	3	49770264	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	201156	49770264	148252166	297	19330										
PBRM1	55193	broad.mit.edu	37	chr3	52582190	52582190	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgtgggcccctttgcttttCagccagtgagagggtaggcg	16	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:52582190C>T	uc003des.2	-	30	4971	c.4959G>A	c.(4957-4959)CTG>CTA	p.L1653L	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Silent_p.L1546L|PBRM1_uc003der.2_Silent_p.L1566L|PBRM1_uc003det.2_Silent_p.L1561L|PBRM1_uc003deu.2_Silent_p.L1616L|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.L1598L|PBRM1_uc010hmk.1_Silent_p.L1573L|PBRM1_uc003dey.2_Silent_p.L1546L	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1653					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CTTTGCTTTTCAGCCAGTGAG	0.507			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	46	121										T	52582190	C	T	52582190	2	4	65	1	0	0	0	0	0	0	0	1	11491	813	29	1		1	PBRM1	3	52582190	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2811926	52582190	145440240	298	19331										
PBRM1	55193	broad.mit.edu	37	chr3	52620683	52620683	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcctcatctcggaagttttCtgggcataacttaaagtatt	7	8	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:52620683C>T	uc003des.2	-	20	3157	c.3145G>A	c.(3145-3147)GAA>AAA	p.E1049K	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E1049K|PBRM1_uc003der.2_Missense_Mutation_p.E1017K|PBRM1_uc003det.2_Missense_Mutation_p.E1064K|PBRM1_uc003deu.2_Missense_Mutation_p.E1064K|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E1049K|PBRM1_uc010hmk.1_Missense_Mutation_p.E1024K|PBRM1_uc003dey.2_Missense_Mutation_p.E1024K|PBRM1_uc003dez.1_Missense_Mutation_p.E1048K|PBRM1_uc003dfb.1_Missense_Mutation_p.E961K|PBRM1_uc003dfa.1_Missense_Mutation_p.E395K	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1049	BAH 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CGGAAGTTTTCTGGGCATAAC	0.358			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	14	66										T	52620683	C	T	52620683	3	4	65	1	0	0	0	0	1	0	0	0	11491	922	32	1	1799	1	PBRM1	3	52620683	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	38493	52620683	145401747	299	19332										
PBRM1	55193	broad.mit.edu	37	chr3	52621527	52621527	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccatacaaccatttttcacCtcaaaaatggggggtggggg	12	9	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:52621527C>G	uc003des.2	-	19	2978	c.2966_splice	c.e19-1	p.G989_splice	PBRM1_uc003dex.2_Splice_Site|PBRM1_uc003deq.2_Splice_Site_p.G989_splice|PBRM1_uc003der.2_Splice_Site_p.G957_splice|PBRM1_uc003det.2_Splice_Site_p.G1004_splice|PBRM1_uc003deu.2_Splice_Site_p.G1004_splice|PBRM1_uc003dev.2_Splice_Site|PBRM1_uc003dew.2_Splice_Site_p.G989_splice|PBRM1_uc010hmk.1_Intron|PBRM1_uc003dey.2_Intron|PBRM1_uc003dez.1_Splice_Site_p.G988_splice|PBRM1_uc003dfb.1_Splice_Site_p.G901_splice|PBRM1_uc003dfa.1_Splice_Site_p.G335_splice	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CATTTTTCACCTCAAAAATGG	0.313			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	13	57										G	52621527	C	G	52621527	5	3	65	1	0	0	0	0	0	0	1	0	11491	695	24	4	1983	4	PBRM1	3	52621527	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	844	52621527	145400903	300	19333										
ACTR8	93973	broad.mit.edu	37	chr3	53908249	53908249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctcccacctgatctaaatGacaaaaagtttctttaaggt	6	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:53908249G>C	uc003dhd.2	-	8	1113	c.1054C>G	c.(1054-1056)CAT>GAT	p.H352D	ACTR8_uc003dhb.2_Intron|ACTR8_uc003dhc.2_Missense_Mutation_p.H241D	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	352					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		TGATCTAAATGACAAAAAGTT	0.328													0	0	0	1	0	16	39										C	53908249	G	C	53908249	3	2	65	1	0	0	0	0	1	0	0	0	217	1290	45	1	844	1	ACTR8	3	53908249	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1286722	53908249	144114181	301	19334										
PDE12	201626	broad.mit.edu	37	chr3	57545645	57545645	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgattccattacctagtcatGaagaagttaccacccaccag	6	12	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:57545645G>A	uc003diw.3	+	3	1870	c.1744G>A	c.(1744-1746)GAA>AAA	p.E582K	PDE12_uc003div.2_3'UTR	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	582							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		ACCTAGTCATGAAGAAGTTAC	0.373													0	0	0	1	0	37	110										A	57545645	G	A	57545645	3	1	65	1	0	0	0	0	1	0	0	0	11632	1291	45	1	1754	1	PDE12	3	57545645	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3637396	57545645	140476785	302	19335										
CADPS	8618	broad.mit.edu	37	chr3	62501761	62501761	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttggcatactctgagagccGagaatagttgactaacgcag	11	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:62501761G>A	uc003dll.2	-	16	2914	c.2554C>T	c.(2554-2556)CGG>TGG	p.R852W	CADPS_uc003dlk.1_Missense_Mutation_p.R356W|CADPS_uc003dlm.2_Missense_Mutation_p.R852W|CADPS_uc003dln.2_Missense_Mutation_p.R835W	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	852	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCTGAGAGCCGAGAATAGTTG	0.433													0	0	0	1	0	22	61										A	62501761	G	A	62501761	3	1	65	1	0	0	0	0	1	0	0	0	2570	1057	37	1	1640	1	CADPS	3	62501761	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4956116	62501761	135520669	303	19336										
MAGI1	9223	broad.mit.edu	37	chr3	65464309	65464309	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaacgtcatcctcctcctCattctccgcgtggactatgc	8	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:65464309C>T	uc003dmn.2	-	4	1241	c.715G>A	c.(715-717)GAG>AAG	p.E239K	MAGI1_uc003dmm.2_Missense_Mutation_p.E239K|MAGI1_uc003dmo.2_Missense_Mutation_p.E239K|MAGI1_uc003dmp.2_Missense_Mutation_p.E239K|MAGI1_uc010hny.2_Missense_Mutation_p.E123K|MAGI1_uc003dmr.2_Missense_Mutation_p.E239K	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	239	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TCCTCCTCCTCATTCTCCGCG	0.517													0	0	0	1	0	26	109										T	65464309	C	T	65464309	3	4	65	1	0	0	0	0	1	0	0	0	9190	835	29	1	3987	1	MAGI1	3	65464309	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2962548	65464309	132558121	304	19337										
LRIG1	26018	broad.mit.edu	37	chr3	66433416	66433416	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggcctgacctgtgttggtGacactgtactcttcactctt	10	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:66433416G>C	uc003dmx.2	-	15	2495	c.2481C>G	c.(2479-2481)GTC>GTG	p.V827V	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Silent_p.V447V|LRIG1_uc003dmw.2_Silent_p.V493V|LRIG1_uc010hnz.2_Silent_p.V543V|LRIG1_uc010hoa.2_Silent_p.V804V	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	827	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTGTGTTGGTGACACTGTACT	0.557													0	0	0	1	0	13	51										C	66433416	G	C	66433416	2	2	65	1	0	0	0	0	0	0	0	1	8944	1277	45	1		1	LRIG1	3	66433416	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	969107	66433416	131589014	305	19338										
KBTBD8	84541	broad.mit.edu	37	chr3	67049613	67049613	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgcaatcagcccttacttCaggtatgatgatggtaggaa	11	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:67049613C>T	uc003dmy.2	+	2	278	c.225C>T	c.(223-225)TTC>TTT	p.F75F	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	75	BTB.									ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		GCCCTTACTTCAGGTATGATG	0.428													0	0	0	1	0	28	98										T	67049613	C	T	67049613	2	4	65	1	0	0	0	0	0	0	0	1	7999	825	29	1		1	KBTBD8	3	67049613	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	616197	67049613	130972817	306	19339										
MITF	4286	broad.mit.edu	37	chr3	70005608	70005608	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtgctcttttcttgaagttGaacgaagaagaagatttaac	9	5	2	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:70005608G>C	uc003dnz.2	+	8	1056	c.940G>C	c.(940-942)GAA>CAA	p.E314Q	MITF_uc011bgb.1_Missense_Mutation_p.E262Q|MITF_uc003doa.2_Missense_Mutation_p.E313Q|MITF_uc003dob.2_Missense_Mutation_p.E298Q|MITF_uc003dod.2_Missense_Mutation_p.E289Q|MITF_uc003doe.2_Missense_Mutation_p.E207Q|MITF_uc003dof.2_Missense_Mutation_p.E213Q	NM_198159	NP_937802	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	320	Basic motif.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		TCTTGAAGTTGAACGAAGAAG	0.383			A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						0	0	0	1	0	9	30										C	70005608	G	C	70005608	3	2	65	1	0	0	0	0	1	0	0	0	9596	1291	45	1	1209	1	MITF	3	70005608	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2955995	70005608	128016822	307	19340										
ROBO1	6091	broad.mit.edu	37	chr3	78649360	78649360	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catttgcttgttctctttgtCtgcttcctgatcctcttgat	6	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:78649360C>G	uc003dqe.2	-	30	5052	c.4844G>C	c.(4843-4845)AGA>ACA	p.R1615T	ROBO1_uc003dqb.2_Missense_Mutation_p.R1576T|ROBO1_uc003dqc.2_Missense_Mutation_p.R1515T|ROBO1_uc003dqd.2_Missense_Mutation_p.R1570T|ROBO1_uc010hoh.2_Missense_Mutation_p.R807T	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1615	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TTCTCTTTGTCTGCTTCCTGA	0.383													0	0	0	1	0	14	39										G	78649360	C	G	78649360	3	3	65	1	0	0	0	0	1	0	0	0	13513	913	32	1	119	1	ROBO1	3	78649360	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8643752	78649360	119373070	308	19341										
OR5K3	403277	broad.mit.edu	37	chr3	98109713	98109713	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttttaggcaacctagttctGatggattcctgctgttcctc	8	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:98109713G>C	uc011bgw.1	+	1	204	c.204G>C	c.(202-204)CTG>CTC	p.L68L		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCTAGTTCTGATGGATTCCT	0.398													0	0	0	1	0	52	209										C	98109713	G	C	98109713	2	2	65	1	0	0	0	0	0	0	0	1	11168	1277	45	1		1	OR5K3	3	98109713	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	19460353	98109713	99912717	309	19342										
BBX	56987	broad.mit.edu	37	chr3	107524303	107524303	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatttcctgcgctgaccagtGaagcgccctttcattgtaaa	8	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:107524303G>A	uc010hpr.2	+	18	3152	c.2825G>A	c.(2824-2826)TGA>TAA	p.*942*	BBX_uc003dwk.3_Silent_p.*912*|BBX_uc003dwl.3_Missense_Mutation_p.E606K|BBX_uc003dwm.3_Silent_p.*912*|BBX_uc003dwo.3_Missense_Mutation_p.E259K	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	942					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCTGACCAGTGAAGCGCCCTT	0.468													0	0	0	1	0	21	88										A	107524303	G	A	107524303	2	1	65	1	0	0	0	0	0	0	0	1	1343	1285	45	1		1	BBX	3	107524303	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9414590	107524303	90498127	310	19343										
DZIP3	9666	broad.mit.edu	37	chr3	108380728	108380728	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcctgtgctcaatagggctCagctggcaaagtaactacag	10	10	2	0	rs139764708		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:108380728C>T	uc003dxd.2	+	20	2626	c.2204C>T	c.(2203-2205)TCA>TTA	p.S735L	DZIP3_uc003dxf.1_Missense_Mutation_p.S735L|DZIP3_uc011bhm.1_Missense_Mutation_p.S186L	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	735					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAATAGGGCTCAGCTGGCAAA	0.358													0	0	0	1	0	10	21										T	108380728	C	T	108380728	3	4	65	1	0	0	0	0	1	0	0	0	4865	838	29	1	2278	1	DZIP3	3	108380728	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	856425	108380728	89641702	311	19344										
DZIP3	9666	broad.mit.edu	37	chr3	108403160	108403160	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtttgcccgggagtcgtctCtgcaactggccaacctagag	12	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:108403160C>T	uc003dxd.2	+	27	3403	c.2981C>T	c.(2980-2982)TCT>TTT	p.S994F	DZIP3_uc003dxf.1_Missense_Mutation_p.S994F|DZIP3_uc011bhm.1_Missense_Mutation_p.S445F	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	994					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGAGTCGTCTCTGCAACTGGC	0.433													0	0	0	1	0	48	222										T	108403160	C	T	108403160	3	4	65	1	0	0	0	0	1	0	0	0	4865	913	32	1	3083	1	DZIP3	3	108403160	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	22432	108403160	89619270	312	19345										
TRAT1	50852	broad.mit.edu	37	chr3	108572556	108572556	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaaacagaatactcatttCtcagacaaggatggagatga	10	6	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:108572556C>G	uc003dxi.1	+	6	537	c.393C>G	c.(391-393)TTC>TTG	p.F131L	TRAT1_uc010hpx.1_Missense_Mutation_p.F94L	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	131	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						ATACTCATTTCTCAGACAAGG	0.463													0	0	0	1	0	13	59										G	108572556	C	G	108572556	3	3	65	1	0	0	0	0	1	0	0	0	16463	912	32	1	415	1	TRAT1	3	108572556	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	169396	108572556	89449874	313	19346										
MORC1	27136	broad.mit.edu	37	chr3	108724086	108724086	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgtcctctacggctcgctGaaagctcaaaggatgaaaga	10	10	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:108724086G>C	uc003dxl.2	-	19	1931	c.1844C>G	c.(1843-1845)TCA>TGA	p.S615*	MORC1_uc011bhn.1_Nonsense_Mutation_p.S594*	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	615					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						ACGGCTCGCTGAAAGCTCAAA	0.358													0	0	0	1	0	6	35										C	108724086	G	C	108724086	4	2	65	1	0	0	0	0	0	1	0	0	9701	1294	45	1	1150	1	MORC1	3	108724086	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	151530	108724086	89298344	314	19347										
SIDT1	54847	broad.mit.edu	37	chr3	113300209	113300209	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcctcatgcatgctgcagtGcccggtgtatgatctcgacc	10	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:113300209G>A	uc003eak.2	+	6	1316	c.665G>A	c.(664-666)TGC>TAC	p.C222Y	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.C222Y|SIDT1_uc011big.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	222	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						ATGCTGCAGTGCCCGGTGTAT	0.463													0	0	0	1	0	15	39										A	113300209	G	A	113300209	3	1	65	1	0	0	0	0	1	0	0	0	14302	1333	46	2	687	2	SIDT1	3	113300209	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4576123	113300209	84722221	315	19348										
GRAMD1C	54762	broad.mit.edu	37	chr3	113627832	113627832	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaaagaggagtcccaaaatGagaaacagaccaaaaagagt	10	7	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:113627832G>A	uc003eaq.3	+	9	893	c.817G>A	c.(817-819)GAG>AAG	p.E273K	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.E106K|GRAMD1C_uc003eas.2_Missense_Mutation_p.E68K	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	273						integral to membrane				ovary(2)|skin(1)	3						GTCCCAAAATGAGAAACAGAC	0.338													0	0	0	1	0	12	29										A	113627832	G	A	113627832	3	1	65	1	0	0	0	0	1	0	0	0	6749	1291	45	1	851	1	GRAMD1C	3	113627832	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	327623	113627832	84394598	316	19349										
ZNF80	7634	broad.mit.edu	37	chr3	113955831	113955831	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtccctgggagtcacattCatggagattgtctcctgtgg	13	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:113955831C>T	uc010hqo.2	-	1	595	c.91G>A	c.(91-93)GAA>AAA	p.E31K	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	31						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GAGTCACATTCATGGAGATTG	0.507													0	0	0	1	0	18	90										T	113955831	C	T	113955831	3	4	65	1	0	0	0	0	1	0	0	0	18165	835	29	1	734	1	ZNF80	3	113955831	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	327999	113955831	84066599	317	19350										
C3orf30	152405	broad.mit.edu	37	chr3	118865552	118865552	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggctatgccatctgaccaGagaggttccagacagaccga	11	12	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:118865552G>C	uc003ecb.1	+	1	556	c.516G>C	c.(514-516)CAG>CAC	p.Q172H	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.Q172H	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	172										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		CATCTGACCAGAGAGGTTCCA	0.527													0	0	0	1	0	24	80										C	118865552	G	C	118865552	3	2	65	1	0	0	0	0	1	0	0	0	2220	933	33	1	518	1	C3orf30	3	118865552	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4909721	118865552	79156878	318	19351										
C3orf15	89876	broad.mit.edu	37	chr3	119469912	119469912	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaatgctgccatgttacttGagaaagaaactcaaaatgag	8	7	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:119469912G>A	uc003ede.3	+	17	2349	c.2272G>A	c.(2272-2274)GAG>AAG	p.E758K	C3orf15_uc010hqz.2_Missense_Mutation_p.E696K|C3orf15_uc011bjd.1_Missense_Mutation_p.E632K|C3orf15_uc011bje.1_Missense_Mutation_p.E738K|C3orf15_uc003edg.3_RNA|C3orf15_uc003edh.3_RNA	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	594						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		CATGTTACTTGAGAAAGAAAC	0.418													0	0	0	1	0	16	62										A	119469912	G	A	119469912	3	1	65	1	0	0	0	0	1	0	0	0	2209	1291	45	1	2338	1	C3orf15	3	119469912	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	604360	119469912	78552518	319	19352										
POLQ	10721	broad.mit.edu	37	chr3	121207035	121207035	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggagatactacagtatgattCttctcttggacaggaaatat	9	6	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:121207035C>T	uc003eee.3	-	16	4872	c.4743G>A	c.(4741-4743)AAG>AAA	p.K1581K	POLQ_uc003eed.2_Silent_p.K753K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1581					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CAGTATGATTCTTCTCTTGGA	0.383								DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	29	83										T	121207035	C	T	121207035	2	4	65	1	0	0	0	0	0	0	0	1	12208	912	32	1		1	POLQ	3	121207035	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1737123	121207035	76815395	320	19353										
IQCB1	9657	broad.mit.edu	37	chr3	121547358	121547358	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaattgtagtccaaccaccCtggattcgagaataatcttg	8	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:121547358C>T	uc010hre.1	-	4	437	c.222G>A	c.(220-222)CAG>CAA	p.Q74Q	IQCB1_uc003eek.2_Silent_p.Q74Q|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	74					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TCCAACCACCCTGGATTCGAG	0.363													0	0	0	1	0	16	50										T	121547358	C	T	121547358	2	4	65	1	0	0	0	0	0	0	0	1	7803	680	24	2		2	IQCB1	3	121547358	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	340323	121547358	76475072	321	19354										
IQCB1	9657	broad.mit.edu	37	chr3	121547744	121547744	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tataacagggacattctgctCagggctttttgcaacttcag	9	9	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:121547744C>G	uc010hre.1	-	3	279	c.64G>C	c.(64-66)GAG>CAG	p.E22Q	IQCB1_uc003eek.2_Missense_Mutation_p.E22Q|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	22					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		ACATTCTGCTCAGGGCTTTTT	0.348													0	0	0	1	0	8	38										G	121547744	C	G	121547744	3	3	65	1	0	0	0	0	1	0	0	0	7803	835	29	1	1784	1	IQCB1	3	121547744	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	386	121547744	76474686	322	19355										
IQCB1	9657	broad.mit.edu	37	chr3	121547781	121547781	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagcagctatagataagatCcttgggtctgtacctgttgg	11	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:121547781C>A	uc010hre.1	-	3	242	c.27G>T	c.(25-27)AGG>AGT	p.R9S	IQCB1_uc003eek.2_Missense_Mutation_p.R9S|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	9					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TAGATAAGATCCTTGGGTCTG	0.348													1	0	0.00116845	1	0.001181	6	40										A	121547781	C	A	121547781	3	1	65	1	0	0	0	0	1	0	0	0	7803	854	30	3	1821	3	IQCB1	3	121547781	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	37	121547781	76474649	323	19356										
KALRN	8997	broad.mit.edu	37	chr3	123987853	123987853	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagctcaagaaaaaggtgctGaaggcccctgtggaggagct	14	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:123987853G>A	uc003ehg.2	+	5	841	c.714G>A	c.(712-714)CTG>CTA	p.L238L	KALRN_uc010hrv.1_Silent_p.L238L|KALRN_uc003ehf.1_Silent_p.L238L|KALRN_uc011bjy.1_Silent_p.L238L	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	238	Spectrin 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AAAAGGTGCTGAAGGCCCCTG	0.627													0	0	0	1	0	11	32										A	123987853	G	A	123987853	2	1	65	1	0	0	0	0	0	0	0	1	7975	1277	45	1		1	KALRN	3	123987853	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2440072	123987853	74034577	324	19357										
PLXNA1	5361	broad.mit.edu	37	chr3	126722265	126722265	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccccatcctgcgagacctCgtcctcagccccaaccacca	6	21	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:126722265C>T	uc003ejg.2	+	3	1405	c.1401C>T	c.(1399-1401)CTC>CTT	p.L467L		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	490	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TGCGAGACCTCGTCCTCAGCC	0.672													0	0	0	1	0	25	63										T	126722265	C	T	126722265	2	4	65	1	0	0	0	0	0	0	0	1	12119	871	31	1		1	PLXNA1	3	126722265	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2734412	126722265	71300165	325	19358										
PIK3R4	30849	broad.mit.edu	37	chr3	130464012	130464012	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaatatctgaaaaataactCtctacagaaaggatctggga	8	6	3	3	rs143147652		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:130464012C>G	uc003enj.2	-	2	632	c.51G>C	c.(49-51)GAG>GAC	p.E17D		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	17					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						AAAAATAACTCTCTACAGAAA	0.438													0	0	0	1	0	15	40										G	130464012	C	G	130464012	3	3	65	1	0	0	0	0	1	0	0	0	11921	912	32	1	4101	1	PIK3R4	3	130464012	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3741747	130464012	67558418	326	19359										
ACPP	55	broad.mit.edu	37	chr3	132051183	132051183	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acacagttcctctttctgaaGatcaggtcagtatactggga	9	9	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:132051183G>T	uc010htp.2	+	4	541	c.451G>T	c.(451-453)GAT>TAT	p.D151Y	ACPP_uc003eon.3_Missense_Mutation_p.D151Y|ACPP_uc003eop.3_Missense_Mutation_p.D151Y	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	151						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						TCTTTCTGAAGATCAGGTCAG	0.517													1	0	6.40141e-05	1	6.50516e-05	12	44										T	132051183	G	T	132051183	3	4	65	1	0	0	0	0	1	0	0	0	167	942	33	3	465	3	ACPP	3	132051183	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1587171	132051183	65971247	327	19360										
AMOTL2	51421	broad.mit.edu	37	chr3	134080563	134080563	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagagcctgctccagcagctCggcacgccgccgctggtcct	12	18	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:134080563C>T	uc003eqf.2	-	6	1657	c.1540G>A	c.(1540-1542)GAG>AAG	p.E514K	AMOTL2_uc003eqg.1_Missense_Mutation_p.E456K|AMOTL2_uc003eqh.1_Missense_Mutation_p.E456K|AMOTL2_uc003eqe.1_Missense_Mutation_p.E81K	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	456	Potential.									large_intestine(1)	1						TCCAGCAGCTCGGCACGCCGC	0.652													0	0	0	1	0	13	33										T	134080563	C	T	134080563	3	4	65	1	0	0	0	0	1	0	0	0	584	893	31	1	996	1	AMOTL2	3	134080563	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2029380	134080563	63941867	328	19361										
PPP2R3A	5523	broad.mit.edu	37	chr3	135720716	135720716	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgccagtgggaaaataaaaGaattttcctttgaaaaactc	7	6	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:135720716G>C	uc003eqv.1	+	2	941	c.376G>C	c.(376-378)GAA>CAA	p.E126Q	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	126					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						GAAAATAAAAGAATTTTCCTT	0.378													0	0	0	1	0	5	27										C	135720716	G	C	135720716	3	2	65	1	0	0	0	0	1	0	0	0	12388	943	33	1	378	1	PPP2R3A	3	135720716	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1640153	135720716	62301714	329	19362										
ZBTB38	253461	broad.mit.edu	37	chr3	141161785	141161785	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgttttccccgctggacttGagggcaagtttcaaaaaggt	11	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:141161785G>C	uc003etw.2	+	8	1537	c.555G>C	c.(553-555)TTG>TTC	p.L185F	ZBTB38_uc010hun.2_Missense_Mutation_p.L182F|ZBTB38_uc010huo.2_Missense_Mutation_p.L185F|ZBTB38_uc003ety.2_Missense_Mutation_p.L185F|ZBTB38_uc010hup.2_Missense_Mutation_p.L186F	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	185					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CGCTGGACTTGAGGGCAAGTT	0.498													0	0	0	1	0	24	122										C	141161785	G	C	141161785	3	2	65	1	0	0	0	0	1	0	0	0	17536	1281	45	1	557	1	ZBTB38	3	141161785	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5441069	141161785	56860645	330	19363										
RASA2	5922	broad.mit.edu	37	chr3	141272699	141272699	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctcttttattctaccttagCatcaaggcatgccatgggtt	7	10	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:141272699C>T	uc003etz.1	+	6	528	c.528C>T	c.(526-528)CAC>CAT	p.H176H	RASA2_uc010huq.1_Silent_p.H176H|RASA2_uc003eua.1_Silent_p.H176H|RASA2_uc011bnc.1_5'UTR	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	176	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						TCTACCTTAGCATCAAGGCAT	0.333													0	0	0	1	0	19	62										T	141272699	C	T	141272699	2	4	65	1	0	0	0	0	0	0	0	1	13061	724	25	2		2	RASA2	3	141272699	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	110914	141272699	56749731	331	19364										
RASA2	5922	broad.mit.edu	37	chr3	141328358	141328358	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtttacttaagctgcagaaGatggaaggtaaatacacaat	9	5	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:141328358G>A	uc003etz.1	+	22	2322	c.2322G>A	c.(2320-2322)AAG>AAA	p.K774K	RASA2_uc010huq.1_Silent_p.K778K|RASA2_uc003eua.1_Silent_p.K775K	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	774					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity	p.K774R(1)		ovary(2)|lung(2)|breast(1)|skin(1)	6						AGCTGCAGAAGATGGAAGGTA	0.313													0	0	0	1	0	16	27										A	141328358	G	A	141328358	2	1	65	1	0	0	0	0	0	0	0	1	13061	933	33	1		1	RASA2	3	141328358	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	55659	141328358	56694072	332	19365										
PLSCR1	5359	broad.mit.edu	37	chr3	146234923	146234923	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagtgcttggaaattttgCcaaccacacactgttcatca	6	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:146234923C>T	uc003evx.3	-	8	1158	c.770G>A	c.(769-771)GGC>GAC	p.G257D	PLSCR1_uc003evy.3_Missense_Mutation_p.G250D|PLSCR1_uc011bnn.1_Missense_Mutation_p.G176D|PLSCR1_uc003evz.3_RNA	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	257	Cytoplasmic.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						GGAAATTTTGCCAACCACACA	0.318													0	0	0	1	0	4	68										T	146234923	C	T	146234923	3	4	65	1	0	0	0	0	1	0	0	0	12109	739	26	2	194	2	PLSCR1	3	146234923	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4906565	146234923	51787507	333	19366										
HPS3	84343	broad.mit.edu	37	chr3	148871318	148871318	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatggatgtctgtgctttaaGaatacagcttttcataggct	9	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:148871318G>C	uc003ewu.1	+	7	1423	c.1283G>C	c.(1282-1284)AGA>ACA	p.R428T	HPS3_uc003ewt.1_Missense_Mutation_p.R428T|HPS3_uc011bnq.1_Missense_Mutation_p.R263T	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	428						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TGTGCTTTAAGAATACAGCTT	0.378									Hermansky-Pudlak_syndrome				0	0	0	1	0	28	61										C	148871318	G	C	148871318	3	2	65	1	0	0	0	0	1	0	0	0	7340	942	33	1	1309	1	HPS3	3	148871318	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2636395	148871318	49151112	334	19367										
TM4SF4	7104	broad.mit.edu	37	chr3	149205479	149205479	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtttatcatctcagccatttCaatcaacaagggtcctaaat	5	10	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:149205479C>T	uc003exd.1	+	3	569	c.338C>T	c.(337-339)TCA>TTA	p.S113L		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	113	Helical; (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TCAGCCATTTCAATCAACAAG	0.502													0	0	0	1	0	19	62										T	149205479	C	T	149205479	3	4	65	1	0	0	0	0	1	0	0	0	15967	838	29	1	348	1	TM4SF4	3	149205479	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	334161	149205479	48816951	335	19368										
RNF13	11342	broad.mit.edu	37	chr3	149678634	149678634	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgattcagactctgacacaGacagtagtcaagaagaaaat	9	8	3	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:149678634G>A	uc003exn.3	+	11	1673	c.889G>A	c.(889-891)GAC>AAC	p.D297N	RNF13_uc003exp.3_Missense_Mutation_p.D297N|RNF13_uc010hvh.2_Missense_Mutation_p.D178N	NM_007282	NP_009213	O43567	RNF13_HUMAN	ring finger protein 13	297	Cytoplasmic (Potential).				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CTCTGACACAGACAGTAGTCA	0.448													0	0	0	1	0	20	61										A	149678634	G	A	149678634	3	1	65	1	0	0	0	0	1	0	0	0	13437	942	33	1	923	1	RNF13	3	149678634	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	473155	149678634	48343796	336	19369										
TSC22D2	9819	broad.mit.edu	37	chr3	150127514	150127514	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taccctggcggcggctgccaCttcggcccccgcccccggag	13	20	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:150127514C>G	uc003exv.2	+	1	727	c.377C>G	c.(376-378)ACT>AGT	p.T126S	TSC22D2_uc003exw.2_RNA|TSC22D2_uc003exx.2_Missense_Mutation_p.T126S	NM_014779	NP_055594	O75157	T22D2_HUMAN	TSC22 domain family, member 2	126							sequence-specific DNA binding transcription factor activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GCGGCTGCCACTTCGGCCCCC	0.741													0	0	0	1	0	23	47										G	150127514	C	G	150127514	3	3	65	1	0	0	0	0	1	0	0	0	16605	565	20	4	379	4	TSC22D2	3	150127514	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	448880	150127514	47894916	337	19370										
MED12L	116931	broad.mit.edu	37	chr3	150840608	150840608	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcatattagctgagaaactGaagcttaacactttccagga	8	8	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:150840608G>A	uc003eyp.2	+	3	281	c.243G>A	c.(241-243)CTG>CTA	p.L81L	MED12L_uc011bnz.1_Silent_p.L81L|MED12L_uc003eym.1_Silent_p.L81L|MED12L_uc003eyn.2_Silent_p.L81L|MED12L_uc003eyo.2_Silent_p.L81L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	81					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGAGAAACTGAAGCTTAACA	0.378													0	0	0	1	0	4	28										A	150840608	G	A	150840608	2	1	65	1	0	0	0	0	0	0	0	1	9429	1277	45	1		1	MED12L	3	150840608	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	713094	150840608	47181822	338	19371										
MED12L	116931	broad.mit.edu	37	chr3	150840663	150840663	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaccacaagttaatgctaaaGataattattggctggttact	7	6	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:150840663G>C	uc003eyp.2	+	3	336	c.298G>C	c.(298-300)GAT>CAT	p.D100H	MED12L_uc011bnz.1_Missense_Mutation_p.D100H|MED12L_uc003eym.1_Missense_Mutation_p.D100H|MED12L_uc003eyn.2_Missense_Mutation_p.D100H|MED12L_uc003eyo.2_Missense_Mutation_p.D100H	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	100					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TAATGCTAAAGATAATTATTG	0.388													0	0	0	1	0	4	19										C	150840663	G	C	150840663	3	2	65	1	0	0	0	0	1	0	0	0	9429	942	33	1	308	1	MED12L	3	150840663	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	55	150840663	47181767	339	19372										
IGSF10	285313	broad.mit.edu	37	chr3	151165065	151165065	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggtcagagtcctgaaattCagttgctccaagtagcagtg	11	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:151165065C>T	uc011bod.1	-	4	2704	c.2704G>A	c.(2704-2706)GAA>AAA	p.E902K		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	902					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCCTGAAATTCAGTTGCTCCA	0.413													0	0	0	1	0	74	251										T	151165065	C	T	151165065	3	4	65	1	0	0	0	0	1	0	0	0	7597	835	29	1	5227	1	IGSF10	3	151165065	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	324402	151165065	46857365	340	19373										
DHX36	170506	broad.mit.edu	37	chr3	154002700	154002700	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctccaaaaagaatcatttttCcaatatgtggctcaacgggt	7	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:154002700C>T	uc003ezy.3	-	18	2189	c.2108G>A	c.(2107-2109)GGA>GAA	p.G703E	DHX36_uc010hvq.2_Missense_Mutation_p.G689E|DHX36_uc003ezz.3_Missense_Mutation_p.G703E	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	703						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AATCATTTTTCCAATATGTGG	0.418													0	0	0	1	0	22	57										T	154002700	C	T	154002700	3	4	65	1	0	0	0	0	1	0	0	0	4509	855	30	1	950	1	DHX36	3	154002700	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2837635	154002700	44019730	341	19374										
MME	4311	broad.mit.edu	37	chr3	154862187	154862187	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agatccgagaagtttttattCagactttagatgacctcact	7	8	2	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:154862187C>G	uc010hvr.1	+	14	1568	c.1357C>G	c.(1357-1359)CAG>GAG	p.Q453E	MME_uc003fab.1_Missense_Mutation_p.Q453E|MME_uc003fac.1_Missense_Mutation_p.Q453E|MME_uc003fad.1_Missense_Mutation_p.Q453E|MME_uc003fae.1_Missense_Mutation_p.Q453E	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	453	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	AGTTTTTATTCAGACTTTAGA	0.363													0	0	0	1	0	8	32										G	154862187	C	G	154862187	3	3	65	1	0	0	0	0	1	0	0	0	9645	827	29	1	1407	1	MME	3	154862187	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	859487	154862187	43160243	342	19375										
SLC33A1	9197	broad.mit.edu	37	chr3	155571672	155571672	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccggcccgctgagtccaaatGactgtcatcccaaccgcctg	9	17	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:155571672G>A	uc003fan.3	-	1	496	c.115C>T	c.(115-117)CAT>TAT	p.H39Y	SLC33A1_uc003fao.1_Missense_Mutation_p.H39Y	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	39	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAGTCCAAATGACTGTCATCC	0.612													0	0	0	1	0	22	59										A	155571672	G	A	155571672	3	1	65	1	0	0	0	0	1	0	0	0	14566	1290	45	1	1558	1	SLC33A1	3	155571672	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	709485	155571672	42450758	343	19376										
SSR3	6747	broad.mit.edu	37	chr3	156271470	156271470	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgagaacaaatttcacattCttgtatgcaaaggctaccaa	6	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:156271470C>T	uc003fau.2	-	2	291	c.234G>A	c.(232-234)AAG>AAA	p.K78K	SSR3_uc011bop.1_Silent_p.K78K	NM_007107	NP_009038	Q9UNL2	SSRG_HUMAN	signal sequence receptor gamma subunit	78	Lumenal (Potential).				cotranslational protein targeting to membrane	integral to endoplasmic reticulum membrane|microsome|Sec61 translocon complex	protein binding|signal sequence binding				0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			ATTTCACATTCTTGTATGCAA	0.333													0	0	0	1	0	10	37										T	156271470	C	T	156271470	2	4	65	1	0	0	0	0	0	0	0	1	15191	912	32	1		1	SSR3	3	156271470	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	699798	156271470	41750960	344	19377										
SMC4	10051	broad.mit.edu	37	chr3	160119741	160119741	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgataatagaagtttagaaGagattttgaacagcattcct	8	4	0	5	rs141249752	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:160119741G>A	uc003fdh.2	+	3	291	c.178G>A	c.(178-180)GAG>AAG	p.E60K	IFT80_uc003fda.2_Intron|IFT80_uc011boy.1_5'Flank|IFT80_uc003fdd.1_5'Flank|IFT80_uc003fde.1_5'Flank|SMC4_uc003fdf.1_RNA|SMC4_uc003fdg.1_Missense_Mutation_p.E60K|SMC4_uc010hwc.1_Intron|SMC4_uc003fdi.2_Intron|SMC4_uc003fdj.2_Missense_Mutation_p.E60K|SMC4_uc010hwd.2_Missense_Mutation_p.E60K|uc011boz.1_5'Flank|MIR15B_hsa-mir-15b|MI0000438_5'Flank|uc003fdk.2_5'Flank|MIR16-2_hsa-mir-16-2|MI0000115_5'Flank	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	60					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAGTTTAGAAGAGATTTTGAA	0.448													0	0	0	1	0	33	111										A	160119741	G	A	160119741	3	1	65	1	0	0	0	0	1	0	0	0	14785	943	33	1	184	1	SMC4	3	160119741	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3848271	160119741	37902689	345	19378										
SI	6476	broad.mit.edu	37	chr3	164712184	164712184	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtttcattccaggaagcggGatcttgtctctgaaacaaag	10	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:164712184G>A	uc003fei.2	-	41	4764	c.4702C>T	c.(4702-4704)CCC>TCC	p.P1568S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1568	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CAGGAAGCGGGATCTTGTCTC	0.299										HNSCC(35;0.089)			0	0	0	1	0	21	54										A	164712184	G	A	164712184	3	1	65	1	0	0	0	0	1	0	0	0	14297	1174	41	1	813	1	SI	3	164712184	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4592443	164712184	33310246	346	19379										
SLITRK3	22865	broad.mit.edu	37	chr3	164907342	164907342	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagaaaaattccaaaaatcaGaacggtatattttctgaatc	5	6	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:164907342G>A	uc003fej.3	-	2	1721	c.1277C>T	c.(1276-1278)TCT>TTT	p.S426F	SLITRK3_uc003fek.2_Missense_Mutation_p.S426F	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	426	LRR 7.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCAAAAATCAGAACGGTATAT	0.388										HNSCC(40;0.11)			0	0	0	1	0	11	38										A	164907342	G	A	164907342	3	1	65	1	0	0	0	0	1	0	0	0	14744	942	33	1	1660	1	SLITRK3	3	164907342	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	195158	164907342	33115088	347	19380										
SERPINI2	5276	broad.mit.edu	37	chr3	167159970	167159970	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcttcccataaacagaattGattctagggaaaaaaaaaca	5	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:167159970G>A	uc003fer.1	-	8	1203	c.1145C>T	c.(1144-1146)TCA>TTA	p.S382L	SERPINI2_uc003fes.1_Missense_Mutation_p.S392L|SERPINI2_uc003fet.1_Missense_Mutation_p.S382L	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	382					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						AAACAGAATTGATTCTAGGGA	0.313													0	0	0	1	0	7	15										A	167159970	G	A	167159970	3	1	65	1	0	0	0	0	1	0	0	0	14119	1294	45	1	76	1	SERPINI2	3	167159970	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2252628	167159970	30862460	348	19381										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	10	32										A	178936091	G	A	178936091	3	1	65	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11776121	178936091	19086339	349	19382										
ZNF639	51193	broad.mit.edu	37	chr3	179050806	179050806	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgataccgagacgtcaaatGacttgccaaaatttgcagat	8	9	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:179050806G>A	uc003fjq.1	+	5	542	c.199G>A	c.(199-201)GAC>AAC	p.D67N	ZNF639_uc003fjr.1_Missense_Mutation_p.D67N	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	67					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			gacgtcaaatgacttgccaaa	0.05													0	0	0	1	0	2	1										A	179050806	G	A	179050806	3	1	65	1	0	0	0	0	1	0	0	0	18053	1290	45	1	209	1	ZNF639	3	179050806	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	114715	179050806	18971624	350	19383										
ACTL6A	86	broad.mit.edu	37	chr3	179291249	179291249	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccatcctgttctcatgtcaGaggcaccggtgagataaaga	10	10	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:179291249G>C	uc003fjw.2	+	4	543	c.370G>C	c.(370-372)GAG>CAG	p.E124Q	ACTL6A_uc003fjx.2_Missense_Mutation_p.E82Q|ACTL6A_uc003fjy.2_Missense_Mutation_p.E82Q	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	124					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			TCTCATGTCAGAGGCACCGGT	0.323													0	0	0	1	0	19	42										C	179291249	G	C	179291249	3	2	65	1	0	0	0	0	1	0	0	0	198	943	33	1	384	1	ACTL6A	3	179291249	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	240443	179291249	18731181	351	19384										
PEX5L	51555	broad.mit.edu	37	chr3	179533669	179533669	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgcatctccagggtcctGaagaattgctgcttccatga	9	12	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:179533669G>A	uc003fki.1	-	10	1193	c.1063C>T	c.(1063-1065)CAG>TAG	p.Q355*	PEX5L_uc011bqd.1_Nonsense_Mutation_p.Q312*|PEX5L_uc011bqe.1_Nonsense_Mutation_p.Q163*|PEX5L_uc011bqf.1_Nonsense_Mutation_p.Q247*|PEX5L_uc003fkj.1_Nonsense_Mutation_p.Q320*|PEX5L_uc010hxd.1_Nonsense_Mutation_p.Q353*|PEX5L_uc011bqg.1_Nonsense_Mutation_p.Q331*|PEX5L_uc011bqh.1_Nonsense_Mutation_p.Q296*	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	355					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			CCAGGGTCCTGAAGAATTGCT	0.507													0	0	0	1	0	20	68										A	179533669	G	A	179533669	4	1	65	1	0	0	0	0	0	1	0	0	11749	1299	45	1	841	1	PEX5L	3	179533669	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	242420	179533669	18488761	352	19385										
TTC14	151613	broad.mit.edu	37	chr3	180322650	180322650	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttttttaaggagaagtgttGagctaaatagcaattctttg	9	3	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:180322650G>A	uc003fkk.2	+	6	844	c.712G>A	c.(712-714)GAG>AAG	p.E238K	TTC14_uc003fkl.2_Missense_Mutation_p.E238K|TTC14_uc003fkm.2_Missense_Mutation_p.E238K	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	238	TPR 1.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GAGAAGTGTTGAGCTAAATAG	0.303													0	0	0	1	0	4	26										A	180322650	G	A	180322650	3	1	65	1	0	0	0	0	1	0	0	0	16678	1291	45	1	734	1	TTC14	3	180322650	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	788981	180322650	17699780	353	19386										
DCUN1D1	54165	broad.mit.edu	37	chr3	182683333	182683333	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaagcactcacctttgtatCtattgtacagctgttctaac	6	11	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:182683333C>G	uc003fld.1	-	2	261	c.212G>C	c.(211-213)AGA>ACA	p.R71T	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	71	DCUN1.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			ACCTTTGTATCTATTGTACAG	0.328													0	0	0	1	0	5	11										G	182683333	C	G	182683333	3	3	65	1	0	0	0	0	1	0	0	0	4313	913	32	1	591	1	DCUN1D1	3	182683333	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2360683	182683333	15339097	354	19387										
B3GNT5	84002	broad.mit.edu	37	chr3	182987774	182987774	+	Missense_Mutation	SNP	C	C	T													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctttgtgaatgataccctgtCtcttaagcacacctcagcgg							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:182987774C>T	uc003flk.2	+	2	718	c.188C>T	c.(187-189)TCT>TTT	p.S63F	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.S63F|B3GNT5_uc003flm.2_Missense_Mutation_p.S63F	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	63	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GATACCCTGTCTCTTAAGCAC	0.393													0	0	0	1	0	24	83										T	182987774	C	T	182987774	3	4	65	1	0	0	0	0	1	0	0	0	1260	913	32	1	190	1	B3GNT5	3	182987774	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	304441	182987774	15034656	355	19388	96	2								
B3GNT5	84002	broad.mit.edu	37	chr3	182987776	182987776	+	Missense_Mutation	SNP	C	C	T													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgtgaatgataccctgtctCttaagcacacctcagcgggg							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:182987776C>T	uc003flk.2	+	2	720	c.190C>T	c.(190-192)CTT>TTT	p.L64F	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.L64F|B3GNT5_uc003flm.2_Missense_Mutation_p.L64F	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	64	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TACCCTGTCTCTTAAGCACAC	0.403													0	0	0	1	0	24	83										T	182987776	C	T	182987776	3	4	65	1	0	0	0	0	1	0	0	0	1260	913	32	1	192	1	B3GNT5	3	182987776	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2	182987776	15034654	356	19389	96	2								
HTR3E	285242	broad.mit.edu	37	chr3	183823613	183823613	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctcgtgcccagtggctttCtggttgccatcgatgccctc	10	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:183823613C>G	uc010hxq.2	+	7	1247	c.781C>G	c.(781-783)CTG>GTG	p.L261V	HTR3E_uc003fml.3_Missense_Mutation_p.L246V|HTR3E_uc003fmm.2_Missense_Mutation_p.L276V|HTR3E_uc010hxr.2_Missense_Mutation_p.L287V|HTR3E_uc003fmn.2_Missense_Mutation_p.L261V	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	261	Helical; Name=1; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CAGTGGCTTTCTGGTTGCCAT	0.547													0	0	0	1	0	29	113										G	183823613	C	G	183823613	3	3	65	1	0	0	0	0	1	0	0	0	7448	912	32	1	848	1	HTR3E	3	183823613	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	835837	183823613	14198817	357	19390										
EIF4G1	1981	broad.mit.edu	37	chr3	184043095	184043095	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcaaccagatggaaaaaatCattaaagaaaagaagacgtc	7	6	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:184043095C>A	uc003fnp.2	+	19	3093	c.2895C>A	c.(2893-2895)ATC>ATA	p.I965I	EIF4G1_uc003fno.1_Silent_p.I906I|EIF4G1_uc010hxw.1_Silent_p.I801I|EIF4G1_uc003fnt.2_Silent_p.I676I|EIF4G1_uc003fnq.2_Silent_p.I878I|EIF4G1_uc003fnr.2_Silent_p.I801I|EIF4G1_uc010hxx.2_Silent_p.I972I|EIF4G1_uc003fns.2_Silent_p.I925I|EIF4G1_uc010hxy.2_Silent_p.I972I|EIF4G1_uc003fnv.3_Silent_p.I966I|EIF4G1_uc003fnu.3_Silent_p.I965I|EIF4G1_uc003fnw.2_Silent_p.I972I|EIF4G1_uc003fnx.2_Silent_p.I770I|EIF4G1_uc003fny.3_Silent_p.I769I|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	965	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGGAAAAAATCATTAAAGAAA	0.532													1	0	3.67414e-24	1	3.91955e-24	35	113										A	184043095	C	A	184043095	2	1	65	1	0	0	0	0	0	0	0	1	5036	816	29	3		3	EIF4G1	3	184043095	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	219482	184043095	13979335	358	19391										
MAP3K13	9175	broad.mit.edu	37	chr3	185146691	185146691	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acagcaacacggtggacggaGagagcacaagcggaactgaa	14	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:185146691G>C	uc010hyf.2	+	3	588	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	MAP3K13_uc011brt.1_Intron|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Intron|MAP3K13_uc003fpi.2_Missense_Mutation_p.E108Q|MAP3K13_uc010hyg.2_5'UTR	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	108					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GGTGGACGGAGAGAGCACAAG	0.517													0	0	0	1	0	25	45										C	185146691	G	C	185146691	3	2	65	1	0	0	0	0	1	0	0	0	9247	943	33	1	324	1	MAP3K13	3	185146691	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1103596	185146691	12875739	359	19392										
CLDN16	10686	broad.mit.edu	37	chr3	190105989	190105989	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agacacctgcagcagggcgtGagaaaaagtaaaagaccagt	12	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:190105989G>A	uc003fsi.2	+	1	149	c.81G>A	c.(79-81)GTG>GTA	p.V27V	CLDN16_uc010hze.2_Silent_p.V27V	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	27	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		AGCAGGGCGTGAGAAAAAGTA	0.502													0	0	0	1	0	7	47										A	190105989	G	A	190105989	2	1	65	1	0	0	0	0	0	0	0	1	3477	1277	45	1		1	CLDN16	3	190105989	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4959298	190105989	7916441	360	19393										
HES1	3280	broad.mit.edu	37	chr3	193855564	193855564	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccgcttcctgtccacgtgcGagggcgttaataccgaggtg	13	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:193855564G>C	uc003ftq.1	+	4	621	c.385G>C	c.(385-387)GAG>CAG	p.E129Q		NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	129	Orange.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		GTCCACGTGCGAGGGCGTTAA	0.657													0	0	0	1	0	21	86										C	193855564	G	C	193855564	3	2	65	1	0	0	0	0	1	0	0	0	7065	1059	37	1	399	1	HES1	3	193855564	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3749575	193855564	4166866	361	19394										
RNF168	165918	broad.mit.edu	37	chr3	196199034	196199034	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggcaccatttgctctttatCcacctccttctgaagttgta	6	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr3:196199034C>T	uc003fwq.2	-	6	1910	c.1372G>A	c.(1372-1374)GAT>AAT	p.D458N	RNF168_uc010iah.2_Missense_Mutation_p.D291N|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	458	MIU motif 2.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TGCTCTTTATCCACCTCCTTC	0.438													0	0	0	1	0	47	118										T	196199034	C	T	196199034	3	4	65	1	0	0	0	0	1	0	0	0	13459	855	30	1	347	1	RNF168	3	196199034	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2343470	196199034	1823396	362	19395										
ZNF732	654254	broad.mit.edu	37	chr4	265128	265128	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catccaaaggctttgccacaCtcttcacattcgtaaggttt	6	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:265128C>T	uc011buu.1	-	3	1529	c.1515G>A	c.(1513-1515)GAG>GAA	p.E505E	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	506	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTGCCACACTCTTCACATT	0.388													0	0	0	1	0	4	19										T	265128	C	T	265128	2	4	65	1	0	0	0	0	0	0	0	1	18120	564	20	2		2	ZNF732	4	265128	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		265128	190889148	363	19396										
MAEA	10296	broad.mit.edu	37	chr4	1305911	1305911	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actccgtggtcagcctgctgGacggcgtggtggagaagctc	16	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:1305911G>T	uc003gda.2	+	2	244	c.214G>T	c.(214-216)GAC>TAC	p.D72Y	MAEA_uc010ibs.1_Missense_Mutation_p.D72Y|MAEA_uc003gdb.2_Missense_Mutation_p.D72Y|MAEA_uc011bvb.1_Missense_Mutation_p.D72Y|MAEA_uc003gdc.2_Missense_Mutation_p.D72Y|MAEA_uc003gdd.2_RNA|MAEA_uc011bvc.1_Missense_Mutation_p.D71Y|MAEA_uc011bvd.1_Missense_Mutation_p.D24Y	NM_001017405	NP_001017405	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher isoform 1	72	Extracellular and involved in cell to cell contact.				cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			CAGCCTGCTGGACGGCGTGGT	0.632													1	0	3.07112e-06	1	3.15306e-06	11	54										T	1305911	G	T	1305911	3	4	65	1	0	0	0	0	1	0	0	0	9153	1174	41	3	220	3	MAEA	4	1305911	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1040783	1305911	189848365	364	19397										
POLN	353497	broad.mit.edu	37	chr4	2172900	2172900	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttcttgctccaattccttGagacgagcctgaaaatatga	8	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:2172900G>C	uc003ger.2	-	10	1383	c.1383C>G	c.(1381-1383)CTC>CTG	p.L461L	POLN_uc010ich.1_Silent_p.L52L|POLN_uc011bvi.1_Silent_p.L461L	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	461					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			CCAATTCCTTGAGACGAGCCT	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	16	73										C	2172900	G	C	2172900	2	2	65	1	0	0	0	0	0	0	0	1	12207	1277	45	1		1	POLN	4	2172900	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	866989	2172900	188981376	365	19398										
HTT	3064	broad.mit.edu	37	chr4	3176447	3176447	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttttattcccatttggcaGatggtttgatgtcctccaga	8	10	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:3176447G>A	uc011bvq.1	+	33	4318	c.4173_splice	c.e33-1	p.G1391_splice		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin						establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CCATTTGGCAGATGGTTTGAT	0.423													0	0	0	1	0	14	31										A	3176447	G	A	3176447	5	1	65	1	0	0	0	0	0	0	1	0	7457	956	33	1	4292	1	HTT	4	3176447	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1003547	3176447	187977829	366	19399										
HTT	3064	broad.mit.edu	37	chr4	3213724	3213724	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaatttctggtggccagaaGagtgccctttttgaagcagc	12	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:3213724G>A	uc011bvq.1	+	49	6634	c.6489G>A	c.(6487-6489)AAG>AAA	p.K2163K		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2161					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTGGCCAGAAGAGTGCCCTTT	0.532													0	0	0	1	0	26	94										A	3213724	G	A	3213724	2	1	65	1	0	0	0	0	0	0	0	1	7457	933	33	1		1	HTT	4	3213724	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	37277	3213724	187940552	367	19400										
DOK7	285489	broad.mit.edu	37	chr4	3494825	3494825	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggccacagatgaactgggctCactgctcagcctgccagcag	12	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:3494825C>T	uc003ghd.2	+	7	1182	c.1112C>T	c.(1111-1113)TCA>TTA	p.S371L	DOK7_uc003ghe.2_Missense_Mutation_p.S233L|DOK7_uc003ghf.2_Missense_Mutation_p.H113Y|DOK7_uc003ghg.1_Missense_Mutation_p.S61L	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	371					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GAACTGGGCTCACTGCTCAGC	0.701													0	0	0	1	0	6	19										T	3494825	C	T	3494825	3	4	65	1	0	0	0	0	1	0	0	0	4702	838	29	1	1138	1	DOK7	4	3494825	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	281101	3494825	187659451	368	19401										
LYAR	55646	broad.mit.edu	37	chr4	4276349	4276349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttttcttctgccgttcttCctttctttctcttttattct	2	13	6	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:4276349C>T	uc011bvy.1	-	7	720	c.577G>A	c.(577-579)GAA>AAA	p.E193K	LYAR_uc011bvx.1_Missense_Mutation_p.E76K|LYAR_uc003ght.2_Missense_Mutation_p.E193K	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	193	Potential.|Lys-rich.					nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		tgccgttcttcctttctttct	0.338													0	0	0	1	0	25	88										T	4276349	C	T	4276349	3	4	65	1	0	0	0	0	1	0	0	0	9103	864	30	1	578	1	LYAR	4	4276349	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	781524	4276349	186877927	369	19402										
HTRA3	94031	broad.mit.edu	37	chr4	8293139	8293139	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggtcactcggccgacctgCggcctggggagtttgtggtg	18	10	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:8293139C>T	uc003gla.2	+	4	955	c.751C>T	c.(751-753)CGG>TGG	p.R251W	HTRA3_uc003gkz.2_Missense_Mutation_p.R251W	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	251	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						GGCCGACCTGCGGCCTGGGGA	0.612													0	0	0	1	0	22	105										T	8293139	C	T	8293139	3	4	65	1	0	0	0	0	1	0	0	0	7455	759	27	2	765	2	HTRA3	4	8293139	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4016790	8293139	182861137	370	19403										
SLC2A9	56606	broad.mit.edu	37	chr4	10027568	10027568	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cactttcttcatcttctcctCggtcctttttactgagcttc	4	14	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:10027568C>T	uc003gmd.2	-	2	182	c.23G>A	c.(22-24)CGA>CAA	p.R8Q		NM_001001290	NP_001001290	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	Error:Variant_position_missing_in_Q9NRM0_after_alignment					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						ATCTTCTCCTCGGTCCTTTTT	0.388													0	0	0	1	0	5	57										T	10027568	C	T	10027568	3	4	65	1	0	0	0	0	1	0	0	0	14552	884	31	1	1714	1	SLC2A9	4	10027568	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1734429	10027568	181126708	371	19404										
WDR1	9948	broad.mit.edu	37	chr4	10079487	10079487	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtcacggggcccttggcctCtaggagcttgccctcatcct	12	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:10079487C>T	uc003gmf.2	-	13	1742	c.1459G>A	c.(1459-1461)GAG>AAG	p.E487K	WDR1_uc003gmg.2_Missense_Mutation_p.E347K|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	487	WD 9.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CCCTTGGCCTCTAGGAGCTTG	0.642													0	0	0	1	0	7	26										T	10079487	C	T	10079487	3	4	65	1	0	0	0	0	1	0	0	0	17269	922	32	1	373	1	WDR1	4	10079487	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	51919	10079487	181074789	372	19405										
ZNF518B	85460	broad.mit.edu	37	chr4	10446884	10446884	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagtttcagaacaagctgctGtgtaccattgacaaccttca	7	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:10446884G>A	uc003gmn.2	-	3	1556	c.1069C>T	c.(1069-1071)CAG>TAG	p.Q357*		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACAAGCTGCTGTGTACCATTG	0.453													0	0	0	1	0	36	105										A	10446884	G	A	10446884	4	1	65	1	0	0	0	0	0	1	0	0	17960	1386	48	2	2159	2	ZNF518B	4	10446884	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	367397	10446884	180707392	373	19406										
CC2D2A	57545	broad.mit.edu	37	chr4	15602891	15602891	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctcttcacatgccttattCtgaagtgaagcctttaattg	6	10	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:15602891C>G	uc010idv.2	+	38	4951	c.4706C>G	c.(4705-4707)TCT>TGT	p.S1569C	CC2D2A_uc003gnx.2_Missense_Mutation_p.S1461C|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1569					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						ATGCCTTATTCTGAAGTGAAG	0.333													0	0	0	1	0	6	14										G	15602891	C	G	15602891	3	3	65	1	0	0	0	0	1	0	0	0	2728	913	32	1	5051	1	CC2D2A	4	15602891	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5156007	15602891	175551385	374	19407										
LGI2	55203	broad.mit.edu	37	chr4	25005550	25005550	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggagcggctggacaggatGagatgcgattttccatcgat	15	7	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:25005550G>A	uc003grf.2	-	8	1260	c.1161C>T	c.(1159-1161)CTC>CTT	p.L387L		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	387	EAR 4.					extracellular region					0		Breast(46;0.173)				TGGACAGGATGAGATGCGATT	0.493													0	0	0	1	0	42	123										A	25005550	G	A	25005550	2	1	65	1	0	0	0	0	0	0	0	1	8752	1277	45	1		1	LGI2	4	25005550	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9402659	25005550	166148726	375	19408										
ANAPC4	29945	broad.mit.edu	37	chr4	25419344	25419344	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgttgctgggaatggttttCgaaaagtgtcctgtgtggta	14	4	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:25419344C>T	uc003gro.2	+	28	2311	c.2182C>T	c.(2182-2184)CGA>TGA	p.R728*	ANAPC4_uc003grp.2_Nonsense_Mutation_p.R614*|ANAPC4_uc003grq.2_Nonsense_Mutation_p.R181*	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	728					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				GAATGGTTTTCGAAAAGTGTC	0.398													0	0	0	1	0	30	89										T	25419344	C	T	25419344	4	4	65	1	0	0	0	0	0	1	0	0	604	876	31	1	2288	1	ANAPC4	4	25419344	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	413794	25419344	165734932	376	19409										
TLR6	10333	broad.mit.edu	37	chr4	38830852	38830852	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attctgttatgggaaagtctCaaaactgtcaactctgatag	8	7	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:38830852C>G	uc003gtm.2	-	1	309	c.243G>C	c.(241-243)TTG>TTC	p.L81F	TLR6_uc010ifg.1_Missense_Mutation_p.L81F	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	81	LRR 2.|Extracellular (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						GGGAAAGTCTCAAAACTGTCA	0.373													0	0	0	1	0	14	49										G	38830852	C	G	38830852	3	3	65	1	0	0	0	0	1	0	0	0	15952	825	29	1	2151	1	TLR6	4	38830852	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	13411508	38830852	152323424	377	19410										
RFC1	5981	broad.mit.edu	37	chr4	39318616	39318616	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttgataattagtgcgtttCttttcagaatcttcaggact	8	7	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:39318616C>G	uc003gty.1	-	10	1256	c.1122G>C	c.(1120-1122)AAG>AAC	p.K374N	RFC1_uc003gtx.1_Missense_Mutation_p.K374N	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	374					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						TAGTGCGTTTCTTTTCAGAAT	0.378													0	0	0	1	0	15	31										G	39318616	C	G	39318616	3	3	65	1	0	0	0	0	1	0	0	0	13244	912	32	1	2385	1	RFC1	4	39318616	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	487764	39318616	151835660	378	19411										
GABRA4	2557	broad.mit.edu	37	chr4	46979555	46979555	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtccacactttcgttaccatCatattgttcaatctcaaaat	3	11	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:46979555C>T	uc003gxg.2	-	4	505	c.366G>A	c.(364-366)ATG>ATA	p.M122I		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	122	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCGTTACCATCATATTGTTCA	0.363													0	0	0	1	0	16	43										T	46979555	C	T	46979555	3	4	65	1	0	0	0	0	1	0	0	0	6163	826	29	1	1322	1	GABRA4	4	46979555	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7660939	46979555	144174721	379	19412										
ATP10D	57205	broad.mit.edu	37	chr4	47525165	47525165	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagatggaatctgtcacattGagacttctggtcttgatgga	11	7	4	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:47525165G>A	uc003gxk.1	+	4	786	c.622G>A	c.(622-624)GAG>AAG	p.E208K	ATP10D_uc003gxj.3_Missense_Mutation_p.E208K	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	208	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CTGTCACATTGAGACTTCTGG	0.458													0	0	0	1	0	13	50										A	47525165	G	A	47525165	3	1	65	1	0	0	0	0	1	0	0	0	1118	1291	45	1	632	1	ATP10D	4	47525165	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	545610	47525165	143629111	380	19413										
TEC	7006	broad.mit.edu	37	chr4	48140806	48140806	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtatttttcaaaaggcattCtgccttccgtgaatacttcc	6	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:48140806C>G	uc003gxz.2	-	17	1779	c.1688G>C	c.(1687-1689)AGA>ACA	p.R563T		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	563	Protein kinase.		R -> K (in a lung adenocarcinoma sample; somatic mutation).		intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.R563K(1)		lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						AAAAGGCATTCTGCCTTCCGT	0.458													0	0	0	1	0	14	50										G	48140806	C	G	48140806	3	3	65	1	0	0	0	0	1	0	0	0	15739	913	32	1	215	1	TEC	4	48140806	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	615641	48140806	143013470	381	19414										
FIP1L1	81608	broad.mit.edu	37	chr4	54294335	54294335	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgtcagcactgctccacctCtgattccaccaccgggtaaa	7	16	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:54294335C>G	uc003gzy.2	+	13	1345	c.1159C>G	c.(1159-1161)CTG>GTG	p.L387V	PDGFRA_uc003haa.2_Intron|FIP1L1_uc003gzx.3_Missense_Mutation_p.L372V|FIP1L1_uc011bzt.1_Missense_Mutation_p.L351V|FIP1L1_uc011bzu.1_Missense_Mutation_p.L372V|FIP1L1_uc003gzz.2_Missense_Mutation_p.L313V|FIP1L1_uc003hab.2_Missense_Mutation_p.L352V|FIP1L1_uc003hac.2_Missense_Mutation_p.L132V|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_5'UTR|FIP1L1_uc003hae.2_5'UTR	NM_030917	NP_112179	Q6UN15	FIP1_HUMAN	FIP1 like 1 isoform 1	387	Pro-rich.				mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGCTCCACCTCTGATTCCACC	0.289			T	PDGFRA	idiopathic hypereosinophilic syndrome								0	0	0	1	0	13	56										G	54294335	C	G	54294335	3	3	65	1	0	0	0	0	1	0	0	0	5896	912	32	1	1209	1	FIP1L1	4	54294335	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6153529	54294335	136859941	382	19415										
EPHA5	2044	broad.mit.edu	37	chr4	66218798	66218798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agagccattctccatatactCtgtcacgatcatcactggtt	6	12	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:66218798C>G	uc003hcy.2	-	13	2453	c.2260G>C	c.(2260-2262)GAG>CAG	p.E754Q	EPHA5_uc003hcx.2_Missense_Mutation_p.E686Q|EPHA5_uc003hcz.2_Missense_Mutation_p.E732Q|EPHA5_uc011cah.1_Missense_Mutation_p.E755Q|EPHA5_uc011cai.1_Missense_Mutation_p.E733Q|EPHA5_uc003hda.2_Missense_Mutation_p.E755Q	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	754	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TCCATATACTCTGTCACGATC	0.358										TSP Lung(17;0.13)			0	0	0	1	0	14	26										G	66218798	C	G	66218798	3	3	65	1	0	0	0	0	1	0	0	0	5170	922	32	1	877	1	EPHA5	4	66218798	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11924463	66218798	124935478	383	19416										
EPHA5	2044	broad.mit.edu	37	chr4	66231707	66231707	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctatctccttagcaaattCgtggacagcttgattgggat	9	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:66231707C>A	uc003hcy.2	-	11	2186	c.1993G>T	c.(1993-1995)GAA>TAA	p.E665*	EPHA5_uc003hcx.2_Nonsense_Mutation_p.E597*|EPHA5_uc003hcz.2_Nonsense_Mutation_p.E643*|EPHA5_uc011cah.1_Nonsense_Mutation_p.E666*|EPHA5_uc011cai.1_Nonsense_Mutation_p.E644*|EPHA5_uc003hda.2_Nonsense_Mutation_p.E666*	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	665	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TTAGCAAATTCGTGGACAGCT	0.363										TSP Lung(17;0.13)			1	0	1.2644e-06	1	1.30368e-06	21	66										A	66231707	C	A	66231707	4	1	65	1	0	0	0	0	0	1	0	0	5170	893	31	3	1152	3	EPHA5	4	66231707	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	12909	66231707	124922569	384	19417										
GNRHR	2798	broad.mit.edu	37	chr4	68619556	68619556	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtcctgcaaagacactactGaggatccaggccaggccaac	11	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:68619556G>T	uc003hdn.2	-	1	2249	c.498C>A	c.(496-498)CTC>CTA	p.L166L	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Silent_p.L166L	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	166	Helical; Name=4; (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	AGACACTACTGAGGATCCAGG	0.463													1	0	1.12685e-05	1	1.14925e-05	9	29										T	68619556	G	T	68619556	2	4	65	1	0	0	0	0	0	0	0	1	6549	1277	45	3		3	GNRHR	4	68619556	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2387849	68619556	122534720	385	19418										
GC	2638	broad.mit.edu	37	chr4	72649680	72649680	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caacaaaagaaatcttacctCtctctaaagcatgtccaaat	3	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:72649680C>G	uc003hge.2	-	1	209	c.56G>C	c.(55-57)AGA>ACA	p.R19T	GC_uc010iie.2_Missense_Mutation_p.R19T|GC_uc010iif.2_Missense_Mutation_p.R38T	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	19	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	AATCTTACCTCTCTCTAAAGC	0.363													0	0	0	1	0	16	44										G	72649680	C	G	72649680	3	3	65	1	0	0	0	0	1	0	0	0	6282	913	32	1	1416	1	GC	4	72649680	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4030124	72649680	118504596	386	19419										
CXCL13	10563	broad.mit.edu	37	chr4	78528941	78528941	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccctagacgcttcattgatcGaattcaaatcttgccccgtg	7	13	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:78528941G>A	uc003hkr.2	+	3	227	c.149G>A	c.(148-150)CGA>CAA	p.R50Q		NM_006419	NP_006410	O43927	CXL13_HUMAN	chemokine (C-X-C motif) ligand 13 (B-cell	50					activation of Rap GTPase activity|B cell chemotaxis|cell-cell signaling|chronic inflammatory response|defense response to bacterium|elevation of cytosolic calcium ion concentration|endothelial cell chemotaxis to fibroblast growth factor|germinal center formation|lymphocyte chemotaxis across high endothelial venule|negative regulation of apoptosis|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of integrin activation|positive regulation of T cell chemotaxis|regulation of angiogenesis|regulation of humoral immune response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|CXCR3 chemokine receptor binding|CXCR5 chemokine receptor binding|fibroblast growth factor 2 binding|heparin binding|protein heterodimerization activity|receptor agonist activity				0						TTCATTGATCGAATTCAAATC	0.393													0	0	0	1	0	21	66										A	78528941	G	A	78528941	3	1	65	1	0	0	0	0	1	0	0	0	4081	1058	37	1	155	1	CXCL13	4	78528941	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5879261	78528941	112625335	387	19420										
CNOT6L	246175	broad.mit.edu	37	chr4	78695757	78695757	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgacagatccaggtaaaccaGattatgaagcttggcaatat	9	7	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:78695757G>A	uc011ccd.1	-	3	372	c.241C>T	c.(241-243)CTG>TTG	p.L81L	CNOT6L_uc003hks.2_Silent_p.L81L|CNOT6L_uc011cce.1_Silent_p.L81L	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	81	LRR 2.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						AGGTAAACCAGATTATGAAGC	0.418													0	0	0	1	0	8	30										A	78695757	G	A	78695757	2	1	65	1	0	0	0	0	0	0	0	1	3623	933	33	1		1	CNOT6L	4	78695757	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	166816	78695757	112458519	388	19421										
GK2	2712	broad.mit.edu	37	chr4	80328225	80328225	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaggccacagagtatccctCttgcactgggctcccaataa	9	13	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:80328225C>G	uc003hlu.2	-	1	1148	c.1130G>C	c.(1129-1131)AGA>ACA	p.R377T		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	377					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						GAGTATCCCTCTTGCACTGGG	0.428													0	0	0	1	0	27	107										G	80328225	C	G	80328225	3	3	65	1	0	0	0	0	1	0	0	0	6421	913	32	1	535	1	GK2	4	80328225	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1632468	80328225	110826051	389	19422										
PRKG2	5593	broad.mit.edu	37	chr4	82056420	82056420	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgtcacacaagcaacgcaGaatttggaggtgggttcatc	11	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:82056420G>C	uc003hmh.2	-	13	1679	c.1665C>G	c.(1663-1665)TTC>TTG	p.F555L	PRKG2_uc011ccf.1_Missense_Mutation_p.F135L|PRKG2_uc011ccg.1_Missense_Mutation_p.F135L|PRKG2_uc011cch.1_Missense_Mutation_p.F526L	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	555	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						AAGCAACGCAGAATTTGGAGG	0.408													0	0	0	1	0	21	49										C	82056420	G	C	82056420	3	2	65	1	0	0	0	0	1	0	0	0	12523	933	33	1	647	1	PRKG2	4	82056420	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1728195	82056420	109097856	390	19423										
MAPK10	5602	broad.mit.edu	37	chr4	87023143	87023143	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtctaattccatctgaatCacttgacataagttggcatc	7	9	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:87023143C>T	uc003hpq.2	-	6	535	c.468G>A	c.(466-468)GTG>GTA	p.V156V	MAPK10_uc010ikg.2_Silent_p.V118V|MAPK10_uc003hpr.2_Silent_p.V118V|MAPK10_uc003hps.2_Silent_p.V156V|MAPK10_uc003hpt.2_Silent_p.V156V|MAPK10_uc003hpu.2_Silent_p.V156V|MAPK10_uc003hpv.2_Silent_p.V11V|MAPK10_uc010ikh.1_RNA|MAPK10_uc003hpn.2_5'Flank|MAPK10_uc003hpo.2_Silent_p.V11V|MAPK10_uc011ccw.1_Silent_p.V42V|MAPK10_uc003hpp.2_Silent_p.V11V	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	156	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		CCATCTGAATCACTTGACATA	0.408													0	0	0	1	0	31	133										T	87023143	C	T	87023143	2	4	65	1	0	0	0	0	0	0	0	1	9272	813	29	1		1	MAPK10	4	87023143	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4966723	87023143	104131133	391	19424										
PTPN13	5783	broad.mit.edu	37	chr4	87622524	87622524	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acacaagatgagaattatttCaaggacattttatcagataa	6	5	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:87622524C>G	uc003hpz.2	+	7	1245	c.765C>G	c.(763-765)TTC>TTG	p.F255L	PTPN13_uc003hpy.2_Missense_Mutation_p.F255L|PTPN13_uc003hqa.2_Missense_Mutation_p.F255L|PTPN13_uc003hqb.2_Missense_Mutation_p.F255L	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	255						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AGAATTATTTCAAGGACATTT	0.378													0	0	0	1	0	5	15										G	87622524	C	G	87622524	3	3	65	1	0	0	0	0	1	0	0	0	12782	825	29	1	787	1	PTPN13	4	87622524	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	599381	87622524	103531752	392	19425										
SMARCAD1	56916	broad.mit.edu	37	chr4	95185963	95185963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taaggcttatgaacaaatgtGaagacatttcaaataaattg	7	4	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:95185963G>A	uc003htc.3	+	10	1642	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	SMARCAD1_uc003htb.3_Missense_Mutation_p.E463K|SMARCAD1_uc003htd.3_Missense_Mutation_p.E463K|SMARCAD1_uc010ila.2_Missense_Mutation_p.E326K|SMARCAD1_uc011cdw.1_Missense_Mutation_p.E33K	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	463					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		GAACAAATGTGAAGACATTTC	0.348													0	0	0	1	0	16	48										A	95185963	G	A	95185963	3	1	65	1	0	0	0	0	1	0	0	0	14772	1291	45	1	1421	1	SMARCAD1	4	95185963	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7563439	95185963	95968313	393	19426										
C4orf17	84103	broad.mit.edu	37	chr4	100434320	100434320	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctagaaatgtaagctgctttCtagtcaggcacacccctcat	7	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:100434320C>G	uc003huw.2	+	2	405	c.82C>G	c.(82-84)CTA>GTA	p.L28V	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	28											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		AAGCTGCTTTCTAGTCAGGCA	0.458													0	0	0	1	0	22	97										G	100434320	C	G	100434320	3	3	65	1	0	0	0	0	1	0	0	0	2252	912	32	1	84	1	C4orf17	4	100434320	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5248357	100434320	90719956	394	19427										
SGMS2	166929	broad.mit.edu	37	chr4	108820810	108820810	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttacaatgtatgttactactCtacctgtgcctggaatgcat	7	9	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:108820810C>T	uc003hyl.3	+	4	1090	c.535C>T	c.(535-537)CTA>TTA	p.L179L	uc003hym.1_Intron|SGMS2_uc003hyn.2_Silent_p.L179L|SGMS2_uc003hyo.2_Silent_p.L179L	NM_001136258	NP_001129730	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	179	Helical; (Potential).				sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			lung(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TGTTACTACTCTACCTGTGCC	0.398													0	0	0	1	0	25	81										T	108820810	C	T	108820810	2	4	65	1	0	0	0	0	0	0	0	1	14215	912	32	1		1	SGMS2	4	108820810	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8386490	108820810	82333466	395	19428										
EGF	1950	broad.mit.edu	37	chr4	110932606	110932606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacaccaaatggagctgactCagtgaaaactggaattaaaa	8	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:110932606C>G	uc003hzy.3	+	24	4071	c.3619C>G	c.(3619-3621)CAG>GAG	p.Q1207E	EGF_uc011cfu.1_Missense_Mutation_p.Q1165E|EGF_uc011cfv.1_Missense_Mutation_p.Q1166E|EGF_uc010imk.2_3'UTR	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	1207	Cytoplasmic (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GGAGCTGACTCAGTGAAAACT	0.443													0	0	0	1	0	22	97										G	110932606	C	G	110932606	3	3	65	1	0	0	0	0	1	0	0	0	4962	827	29	1	3713	1	EGF	4	110932606	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2111796	110932606	80221670	396	19429										
ELOVL6	79071	broad.mit.edu	37	chr4	110972518	110972518	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagctttcgttgttttcctCattttgccgatgtaggcctc	8	11	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:110972518C>T	uc003hzz.2	-	5	900	c.774G>A	c.(772-774)ATG>ATA	p.M258I	ELOVL6_uc003iaa.2_Missense_Mutation_p.M258I	NM_001130721	NP_001124193	Q9H5J4	ELOV6_HUMAN	elongation of very long chain fatty acids-like	258					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		TTGTTTTCCTCATTTTGCCGA	0.428													0	0	0	1	0	17	65										T	110972518	C	T	110972518	3	4	65	1	0	0	0	0	1	0	0	0	5078	826	29	1	27	1	ELOVL6	4	110972518	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	39912	110972518	80181758	397	19430										
C4orf21	55345	broad.mit.edu	37	chr4	113507724	113507724	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccacttggaaagcacagctCagagccacttatctcctgca	7	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:113507724C>T	uc003iau.2	-	13	4004	c.3793G>A	c.(3793-3795)GAG>AAG	p.E1265K	C4orf21_uc003iav.2_RNA	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	87						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AAGCACAGCTCAGAGCCACTT	0.353													0	0	0	1	0	7	47										T	113507724	C	T	113507724	3	4	65	1	0	0	0	0	1	0	0	0	2254	835	29	1	2585	1	C4orf21	4	113507724	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2535206	113507724	77646552	398	19431										
TRPC3	7222	broad.mit.edu	37	chr4	122853555	122853555	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccttgtaggcattgatcctCgagcgtgagtggctgaagga	14	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:122853555C>T	uc003ieg.2	-	2	932	c.858G>A	c.(856-858)TCG>TCA	p.S286S	TRPC3_uc010inr.2_Silent_p.S213S|TRPC3_uc003ief.2_Silent_p.S213S|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	201	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						CATTGATCCTCGAGCGTGAGT	0.612													0	0	0	1	0	13	55										T	122853555	C	T	122853555	2	4	65	1	0	0	0	0	0	0	0	1	16576	871	31	1		1	TRPC3	4	122853555	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	9345831	122853555	68300721	399	19432										
KIAA1109	84162	broad.mit.edu	37	chr4	123237989	123237989	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggatatcagagaactgaatGaacaggccaaagtaatagat	10	5	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:123237989G>A	uc003ieh.2	+	60	10687	c.10642G>A	c.(10642-10644)GAA>AAA	p.E3548K	KIAA1109_uc003iel.1_Missense_Mutation_p.E1483K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3548					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGAACTGAATGAACAGGCCAA	0.313													0	0	0	1	0	13	52										A	123237989	G	A	123237989	3	1	65	1	0	0	0	0	1	0	0	0	8208	1291	45	1	10880	1	KIAA1109	4	123237989	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	384434	123237989	67916287	400	19433										
FAT4	79633	broad.mit.edu	37	chr4	126238455	126238455	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggacgaggggacccccttcCaaatggaccctgagacggga	14	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:126238455C>G	uc003ifj.3	+	1	889	c.889C>G	c.(889-891)CAA>GAA	p.Q297E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	297	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GACCCCCTTCCAAATGGACCC	0.662											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	17	63										G	126238455	C	G	126238455	3	3	65	1	0	0	0	0	1	0	0	0	5692	595	21	4	891	4	FAT4	4	126238455	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3000466	126238455	64915821	401	19434										
FAT4	79633	broad.mit.edu	37	chr4	126370600	126370600	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caatgcaattagtagatattCtataatggatgcaagtcttc	7	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:126370600C>G	uc003ifj.3	+	9	8429	c.8429C>G	c.(8428-8430)TCT>TGT	p.S2810C	FAT4_uc011cgp.1_Missense_Mutation_p.S1108C|FAT4_uc003ifi.1_Missense_Mutation_p.S288C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2810	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGTAGATATTCTATAATGGAT	0.388													0	0	0	1	0	18	63										G	126370600	C	G	126370600	3	3	65	1	0	0	0	0	1	0	0	0	5692	913	32	1	8463	1	FAT4	4	126370600	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	132145	126370600	64783676	402	19435										
NAA15	80155	broad.mit.edu	37	chr4	140297588	140297588	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acttggtgaagaacaagataGagactcatctttttgccttt	8	7	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:140297588G>A	uc003ihu.1	+	16	2273	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	673	TPR 8.				angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						GAACAAGATAGAGACTCATCT	0.338													0	0	0	1	0	18	44										A	140297588	G	A	140297588	3	1	65	1	0	0	0	0	1	0	0	0	10118	943	33	1	2079	1	NAA15	4	140297588	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13926988	140297588	50856688	403	19436										
MAML3	55534	broad.mit.edu	37	chr4	140811578	140811578	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggctgcgagaattctggctCcttcttctcttcaaagtctt	8	11	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:140811578C>G	uc003ihz.1	-	2	1764	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	338					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					AATTCTGGCTCCTTCTTCTCT	0.512													0	0	0	1	0	18	56										G	140811578	C	G	140811578	3	3	65	1	0	0	0	0	1	0	0	0	9207	864	30	1	2412	1	MAML3	4	140811578	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	513990	140811578	50342698	404	19437										
TBC1D9	23158	broad.mit.edu	37	chr4	141545369	141545369	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttcttgggaatttgctctCttccctacaacccaaatgtc	5	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:141545369C>G	uc010ioj.2	-	20	3251	c.2979G>C	c.(2977-2979)AAG>AAC	p.K993N		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	993						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AATTTGCTCTCTTCCCTACAA	0.353													0	0	0	1	0	5	10										G	141545369	C	G	141545369	3	3	65	1	0	0	0	0	1	0	0	0	15624	912	32	1	829	1	TBC1D9	4	141545369	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	733791	141545369	49608907	405	19438										
OTUD4	54726	broad.mit.edu	37	chr4	146077090	146077090	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacttttaaaaaaaatacctCattgcctgacaaaggtttaa	4	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:146077090C>T	uc003ika.3	-	8	631	c.493G>A	c.(493-495)GAG>AAG	p.E165K	OTUD4_uc003ijz.3_Missense_Mutation_p.E165K	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	230				E -> EQ (in Ref. 1; BAG63836, 3; EAX05045/EAX05046 and 7; AAI18573/ AAI18654).			protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AAAAATACCTCATTGCCTGAC	0.308													0	0	0	1	0	7	33										T	146077090	C	T	146077090	3	4	65	1	0	0	0	0	1	0	0	0	11314	835	29	1	2712	1	OTUD4	4	146077090	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4531721	146077090	45077186	406	19439										
SH3D19	152503	broad.mit.edu	37	chr4	152096430	152096430	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggtttcttgggcagtcctGaggtttctatgtttgtctga	12	7	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:152096430G>C	uc010ipl.1	-	7	1176	c.86C>G	c.(85-87)TCA>TGA	p.S29*	SH3D19_uc003imc.2_Nonsense_Mutation_p.S29*|SH3D19_uc003ime.2_Nonsense_Mutation_p.S29*|SH3D19_uc010ipm.2_Nonsense_Mutation_p.S29*	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	29					cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				GGGCAGTCCTGAGGTTTCTAT	0.433													0	0	0	1	0	38	122										C	152096430	G	C	152096430	4	2	65	1	0	0	0	0	0	1	0	0	14249	1294	45	1	2346	1	SH3D19	4	152096430	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6019340	152096430	39057846	407	19440										
FHDC1	85462	broad.mit.edu	37	chr4	153897464	153897464	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagacctgccgcgcccactcCgagggccctgagagtcccaa	11	17	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:153897464C>T	uc003inf.2	+	11	3096	c.3021C>T	c.(3019-3021)TCC>TCT	p.S1007S		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1007					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GCGCCCACTCCGAGGGCCCTG	0.622													0	0	0	1	0	23	83										T	153897464	C	T	153897464	2	4	65	1	0	0	0	0	0	0	0	1	5876	639	23	2		2	FHDC1	4	153897464	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1801034	153897464	37256812	408	19441										
KIAA0922	23240	broad.mit.edu	37	chr4	154514972	154514972	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttggcactgatatgcagatGattaatttcacaactggtga	9	6	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:154514972G>C	uc003inm.3	+	19	1993	c.1941G>C	c.(1939-1941)ATG>ATC	p.M647I	KIAA0922_uc010ipp.2_Missense_Mutation_p.M648I|KIAA0922_uc010ipq.2_Missense_Mutation_p.M416I	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	647	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				ATATGCAGATGATTAATTTCA	0.373													0	0	0	1	0	8	36										C	154514972	G	C	154514972	3	2	65	1	0	0	0	0	1	0	0	0	8201	1290	45	1	2018	1	KIAA0922	4	154514972	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	617508	154514972	36639304	409	19442										
TLR2	7097	broad.mit.edu	37	chr4	154625437	154625437	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgcattcccaagacactgGaaattttagatgttagcaac	8	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:154625437G>C	uc003inq.2	+	3	1597	c.1378G>C	c.(1378-1380)GAA>CAA	p.E460Q	TLR2_uc003inr.2_Missense_Mutation_p.E460Q|TLR2_uc003ins.2_Missense_Mutation_p.E460Q	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	460	LRR 12.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				CAAGACACTGGAAATTTTAGA	0.358													0	0	0	1	0	26	56										C	154625437	G	C	154625437	3	2	65	1	0	0	0	0	1	0	0	0	15948	1175	41	1	1380	1	TLR2	4	154625437	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	110465	154625437	36528839	410	19443										
SFRP2	6423	broad.mit.edu	37	chr4	154702903	154702903	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atctccttcacttttattttCagtgctatgagggagggcag	10	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:154702903C>T	uc003inv.1	-	3	829	c.588G>A	c.(586-588)CTG>CTA	p.L196L		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	196	NTR.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				CTTTTATTTTCAGTGCTATGA	0.458													0	0	0	1	0	30	98										T	154702903	C	T	154702903	2	4	65	1	0	0	0	0	0	0	0	1	14162	813	29	1		1	SFRP2	4	154702903	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	77466	154702903	36451373	411	19444										
DCHS2	54798	broad.mit.edu	37	chr4	155180751	155180751	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacactgatgcctggtaaatGctttgttcaaagcatggtga	11	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:155180751G>A	uc003inw.2	-	20	5370	c.5370C>T	c.(5368-5370)AGC>AGT	p.S1790S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1790	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCTGGTAAATGCTTTGTTCAA	0.328													0	0	0	1	0	11	146										A	155180751	G	A	155180751	2	1	65	1	0	0	0	0	0	0	0	1	4288	1310	46	2		2	DCHS2	4	155180751	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	477848	155180751	35973525	412	19445										
ADAM29	11086	broad.mit.edu	37	chr4	175898316	175898316	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atatataaagtgtaatatctCagatgtccagtgtggaagaa	9	4	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr4:175898316C>T	uc003iuc.2	+	5	2310	c.1640C>T	c.(1639-1641)TCA>TTA	p.S547L	ADAM29_uc003iud.2_Missense_Mutation_p.S547L|ADAM29_uc010irr.2_Missense_Mutation_p.S547L|ADAM29_uc011cki.1_Missense_Mutation_p.S547L	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	547	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGTAATATCTCAGATGTCCAG	0.388													0	0	0	1	0	32	109										T	175898316	C	T	175898316	3	4	65	1	0	0	0	0	1	0	0	0	247	838	29	1	1642	1	ADAM29	4	175898316	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	20717565	175898316	15255960	413	19446										
SLC6A19	340024	broad.mit.edu	37	chr5	1208934	1208934	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgtacctggagttcgccatCgggcagcggctgcggcgggg	18	12	0	0	rs146678323	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:1208934C>T	uc003jbw.3	+	2	332	c.276C>T	c.(274-276)ATC>ATT	p.I92I		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	92	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGTTCGCCATCGGGCAGCGGC	0.667													0	0	0	1	0	36	82										T	1208934	C	T	1208934	2	4	65	1	0	0	0	0	0	0	0	1	14682	874	31	1		1	SLC6A19	5	1208934	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		1208934	179706326	414	19447										
IRX4	50805	broad.mit.edu	37	chr5	1879900	1879900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttgagcgtgctggtggtctCgcgcgtggcgttcttgcgcc	16	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:1879900C>T	uc003jcz.2	-	4	573	c.454G>A	c.(454-456)GAG>AAG	p.E152K	IRX4_uc011cmf.1_Missense_Mutation_p.E13K	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	152	Homeobox; TALE-type.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		CTGGTGGTCTCGCGCGTGGCG	0.642													0	0	0	1	0	40	93										T	1879900	C	T	1879900	3	4	65	1	0	0	0	0	1	0	0	0	7846	893	31	1	1113	1	IRX4	5	1879900	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	670966	1879900	179035360	415	19448										
ADCY2	108	broad.mit.edu	37	chr5	7773074	7773074	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacagctgcattctgggactGatatcctgttccgtgttcct	9	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:7773074G>A	uc003jdz.1	+	18	2311	c.2244G>A	c.(2242-2244)CTG>CTA	p.L748L	ADCY2_uc011cmo.1_Silent_p.L568L	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	748	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TTCTGGGACTGATATCCTGTT	0.463													0	0	0	1	0	41	116										A	7773074	G	A	7773074	2	1	65	1	0	0	0	0	0	0	0	1	294	1277	45	1		1	ADCY2	5	7773074	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5893174	7773074	173142186	416	19449										
SEMA5A	9037	broad.mit.edu	37	chr5	9136626	9136626	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcactcaccggacacgcaGagatgctctgttcccactgc	11	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:9136626G>C	uc003jek.2	-	13	2301	c.1589C>G	c.(1588-1590)TCT>TGT	p.S530C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	530	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CGGACACGCAGAGATGCTCTG	0.577													0	0	0	1	0	11	46										C	9136626	G	C	9136626	3	2	65	1	0	0	0	0	1	0	0	0	14037	942	33	1	1679	1	SEMA5A	5	9136626	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1363552	9136626	171778634	417	19450										
CDH6	1004	broad.mit.edu	37	chr5	31316392	31316392	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaacgccccagaatttgctGagttctatgaaacttttgtc	7	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:31316392G>A	uc003jhe.1	+	9	1794	c.1468G>A	c.(1468-1470)GAG>AAG	p.E490K	CDH6_uc003jhd.1_Missense_Mutation_p.E490K	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	490	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AGAATTTGCTGAGTTCTATGA	0.333													0	0	0	1	0	6	27										A	31316392	G	A	31316392	3	1	65	1	0	0	0	0	1	0	0	0	3114	1291	45	1	1498	1	CDH6	5	31316392	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	22179766	31316392	149598868	418	19451										
PDZD2	23037	broad.mit.edu	37	chr5	32093126	32093126	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaggaagcgaaagcacaatCagaggtgagtgaaacacaga	12	7	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:32093126C>G	uc003jhl.2	+	21	8229	c.7841C>G	c.(7840-7842)TCA>TGA	p.S2614*	PDZD2_uc003jhm.2_Nonsense_Mutation_p.S2614*	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2614					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AAAGCACAATCAGAGGTGAGT	0.537											OREG0016544	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	19	80										G	32093126	C	G	32093126	4	3	65	1	0	0	0	0	0	1	0	0	11701	838	29	1	7919	1	PDZD2	5	32093126	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	776734	32093126	148822134	419	19452										
RXFP3	51289	broad.mit.edu	37	chr5	33937997	33937997	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgcactccaacagctgcctCaaccccgtcctctactgcct	6	20	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:33937997C>A	uc003jic.1	+	1	1509	c.1152C>A	c.(1150-1152)CTC>CTA	p.L384L		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	384	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						ACAGCTGCCTCAACCCCGTCC	0.617													1	0	3.50607e-19	1	3.71915e-19	51	147										A	33937997	C	A	33937997	2	1	65	1	0	0	0	0	0	0	0	1	13761	813	29	3		3	RXFP3	5	33937997	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1844871	33937997	146977263	420	19453										
NIPBL	25836	broad.mit.edu	37	chr5	36953855	36953855	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttgcggggattgctagtctCacagaccgtaagtttggtta	12	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:36953855C>T	uc003jkl.3	+	2	556	c.57C>T	c.(55-57)CTC>CTT	p.L19L	NIPBL_uc003jkk.3_Silent_p.L19L	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	19					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTGCTAGTCTCACAGACCGTA	0.348													0	0	0	1	0	19	52										T	36953855	C	T	36953855	2	4	65	1	0	0	0	0	0	0	0	1	10428	813	29	1		1	NIPBL	5	36953855	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3015858	36953855	143961405	421	19454										
RICTOR	253260	broad.mit.edu	37	chr5	38966820	38966820	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtttgttatcacttcaactaGaccctttgaaaataaaaaga	5	7	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:38966820G>C	uc003jlp.2	-	15	1246	c.1222C>G	c.(1222-1224)CTA>GTA	p.L408V	RICTOR_uc003jlo.2_Missense_Mutation_p.L408V|RICTOR_uc010ivf.2_Missense_Mutation_p.L123V	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	408					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					ACTTCAACTAGACCCTTTGAA	0.274													0	0	0	1	0	8	19										C	38966820	G	C	38966820	3	2	65	1	0	0	0	0	1	0	0	0	13358	933	33	1	4000	1	RICTOR	5	38966820	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2012965	38966820	141948440	422	19455										
FYB	2533	broad.mit.edu	37	chr5	39202544	39202544	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatttccctttaaccccagtCaatttgggaaacgcttgctt	6	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:39202544C>G	uc003jls.2	-	1	586	c.519G>C	c.(517-519)TTG>TTC	p.L173F	FYB_uc003jlt.2_Missense_Mutation_p.L173F|FYB_uc003jlu.2_Missense_Mutation_p.L173F|FYB_uc011cpl.1_Missense_Mutation_p.L183F	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	173					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TAACCCCAGTCAATTTGGGAA	0.498													0	0	0	1	0	28	101										G	39202544	C	G	39202544	3	3	65	1	0	0	0	0	1	0	0	0	6124	825	29	1	2042	1	FYB	5	39202544	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	235724	39202544	141712716	423	19456										
FGF10	2255	broad.mit.edu	37	chr5	44388630	44388630	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagaaggaggaggaagaaGagttggtggcctctggtgac	19	4	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:44388630G>C	uc003jog.1	-	1	155	c.155C>G	c.(154-156)TCT>TGT	p.S52C		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	52	Poly-Ser.				actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					GGAGGAAGAAGAGTTGGTGGC	0.547													0	0	0	1	0	28	49										C	44388630	G	C	44388630	3	2	65	1	0	0	0	0	1	0	0	0	5839	942	33	1	483	1	FGF10	5	44388630	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5186086	44388630	136526630	424	19457										
MRPS30	10884	broad.mit.edu	37	chr5	44811174	44811174	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aattattcctcgtggtcatcGaagaggtcgaattgatgact	10	7	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:44811174G>A	uc003joh.2	+	2	703	c.665G>A	c.(664-666)CGA>CAA	p.R222Q	MRPS30_uc003joi.1_RNA	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	222					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					CGTGGTCATCGAAGAGGTCGA	0.373													0	0	0	1	0	15	47										A	44811174	G	A	44811174	3	1	65	1	0	0	0	0	1	0	0	0	9840	1058	37	1	671	1	MRPS30	5	44811174	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	422544	44811174	136104086	425	19458										
IL31RA	133396	broad.mit.edu	37	chr5	55206499	55206499	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatttcaagacattgtcattCagtgagtatttccttcaagc	6	8	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:55206499C>T	uc003jql.2	+	12	1706	c.1641C>T	c.(1639-1641)TTC>TTT	p.F547F	IL31RA_uc003jqm.2_Silent_p.F515F|IL31RA_uc003jqn.2_Silent_p.F547F|IL31RA_uc010iwa.1_Silent_p.F510F|IL31RA_uc003jqo.2_Silent_p.F405F	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	515	Extracellular (Potential).				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CATTGTCATTCAGTGAGTATT	0.463													0	0	0	1	0	34	106										T	55206499	C	T	55206499	2	4	65	1	0	0	0	0	0	0	0	1	7691	840	29	1		1	IL31RA	5	55206499	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	10395325	55206499	125708761	426	19459										
IL6ST	3572	broad.mit.edu	37	chr5	55238517	55238517	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccttggaggagtgtgaggtGaccactgggcaatatgactc	14	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:55238517G>A	uc003jqq.2	-	16	2255	c.2000C>T	c.(1999-2001)TCA>TTA	p.S667L	IL6ST_uc010iwb.2_Missense_Mutation_p.S606L|IL6ST_uc010iwc.2_Missense_Mutation_p.H180Y|IL6ST_uc010iwd.2_5'UTR|IL6ST_uc011cqk.1_Missense_Mutation_p.S378L|IL6ST_uc003jqr.2_3'UTR	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	667	Cytoplasmic (Potential).				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				AGTGTGAGGTGACCACTGGGC	0.368			O		hepatocellular ca								0	0	0	1	0	10	34										A	55238517	G	A	55238517	3	1	65	1	0	0	0	0	1	0	0	0	7703	1294	45	1	764	1	IL6ST	5	55238517	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	32018	55238517	125676743	427	19460										
ADAMTS6	11174	broad.mit.edu	37	chr5	64520832	64520832	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccacagactcgacatctatCttccctagcatcagatccca	4	16	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:64520832C>G	uc003jtp.2	-	17	2924	c.2110G>C	c.(2110-2112)GAT>CAT	p.D704H	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.D325H	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	704					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CGACATCTATCTTCCCTAGCA	0.443													0	0	0	1	0	7	39										G	64520832	C	G	64520832	3	3	65	1	0	0	0	0	1	0	0	0	270	913	32	1	1279	1	ADAMTS6	5	64520832	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	9282315	64520832	116394428	428	19461										
PPWD1	23398	broad.mit.edu	37	chr5	64863366	64863366	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtttgaaagagtctatcttGataatctccccagtgcatcc	7	10	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:64863366G>C	uc003jtv.3	+	2	230	c.223G>C	c.(223-225)GAT>CAT	p.D75H	PPWD1_uc011cqv.1_Missense_Mutation_p.D45H|PPWD1_uc011cqw.1_Intron	NM_015342	NP_056157	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat	75					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		AGTCTATCTTGATAATCTCCC	0.313													0	0	0	1	0	11	36										C	64863366	G	C	64863366	3	2	65	1	0	0	0	0	1	0	0	0	12414	1290	45	1	229	1	PPWD1	5	64863366	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	342534	64863366	116051894	429	19462										
CDK7	1022	broad.mit.edu	37	chr5	68548244	68548244	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtttttttccgtttctaccaGatcaaacttggacatagatc	6	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:68548244G>C	uc003jvs.3	+	3	308	c.127_splice	c.e3-1	p.I43_splice	CDK7_uc010ixd.1_Splice_Site_p.I43_splice|CDK7_uc003jvt.3_Splice_Site_p.I2_splice|CDK7_uc003jvu.3_Splice_Site	NM_001799	NP_001790	P50613	CDK7_HUMAN	cyclin-dependent kinase 7						androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			lung(1)	1		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		GTTTCTACCAGATCAAACTTG	0.259								NER					0	0	0	1	0	32	116										C	68548244	G	C	68548244	5	2	65	1	0	0	0	0	0	0	1	0	3149	956	33	1	136	1	CDK7	5	68548244	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3684878	68548244	112367016	430	19463										
POLK	51426	broad.mit.edu	37	chr5	74892360	74892360	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagaatttggaaatatcagaGaattcagatgactgtcagat	10	4	3	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:74892360G>A	uc003kdw.2	+	13	1938	c.1842G>A	c.(1840-1842)GAG>GAA	p.E614E	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Silent_p.E416E|POLK_uc003kec.2_Silent_p.E524E|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Silent_p.E524E	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	614					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AAATATCAGAGAATTCAGATG	0.368								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	18	103										A	74892360	G	A	74892360	2	1	65	1	0	0	0	0	0	0	0	1	12204	933	33	1		1	POLK	5	74892360	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6344116	74892360	106022900	431	19464										
DMGDH	29958	broad.mit.edu	37	chr5	78322343	78322343	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctcctggcctgcattcatGatagcgtcatacagcgccac	8	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:78322343G>A	uc003kfs.2	-	13	2100	c.2094C>T	c.(2092-2094)ATC>ATT	p.I698I	DMGDH_uc011cte.1_Silent_p.I548I|DMGDH_uc011ctf.1_Silent_p.I497I|DMGDH_uc011ctg.1_Silent_p.I318I	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	698					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		CTGCATTCATGATAGCGTCAT	0.512													0	0	0	1	0	22	74										A	78322343	G	A	78322343	2	1	65	1	0	0	0	0	0	0	0	1	4581	1280	45	1		1	DMGDH	5	78322343	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3429983	78322343	102592917	432	19465										
MSH3	4437	broad.mit.edu	37	chr5	79970869	79970869	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ataatgactgatacttctacCagctatcttctgtgcatctc	5	11	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:79970869C>T	uc003kgz.2	+	7	1348	c.1095C>T	c.(1093-1095)ACC>ACT	p.T365T		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	365					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		ATACTTCTACCAGCTATCTTC	0.323								MMR					0	0	0	1	0	22	65										T	79970869	C	T	79970869	2	4	65	1	0	0	0	0	0	0	0	1	9871	581	21	2		2	MSH3	5	79970869	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1648526	79970869	100944391	433	19466										
CKMT2	1160	broad.mit.edu	37	chr5	80553673	80553673	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gattctgtcgtggactaaaaGaagtaagatgttatctgaga	11	4	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:80553673G>C	uc003khc.3	+	8	1119	c.877G>C	c.(877-879)GAA>CAA	p.E293Q	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Missense_Mutation_p.E293Q|CKMT2_uc003khd.3_Missense_Mutation_p.E293Q|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	293	Phosphagen kinase C-terminal.				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	TGGACTAAAAGAAGTAAGATG	0.358													0	0	0	1	0	8	33										C	80553673	G	C	80553673	3	2	65	1	0	0	0	0	1	0	0	0	3451	943	33	1	899	1	CKMT2	5	80553673	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	582804	80553673	100361587	434	19467										
SSBP2	23635	broad.mit.edu	37	chr5	80742738	80742738	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggccctccacctcctggagGaccctaaataattatacaaa	6	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:80742738G>A	uc003kho.2	-	12	938	c.727C>T	c.(727-729)CCT>TCT	p.P243S	RNU5E_uc011cto.1_Intron|SSBP2_uc010jar.2_Missense_Mutation_p.P131S|SSBP2_uc003khn.2_Missense_Mutation_p.P117S|SSBP2_uc003khp.2_Missense_Mutation_p.P251S|SSBP2_uc011ctp.1_Missense_Mutation_p.P223S|SSBP2_uc011ctq.1_Missense_Mutation_p.P221S|SSBP2_uc011ctr.1_Missense_Mutation_p.P213S	NM_012446	NP_036578	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	243	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	haematopoietic_and_lymphoid_tissue(4)|skin(1)	5		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		CCTCCTGGAGGACCCTAAATA	0.343													0	0	0	1	0	14	32										A	80742738	G	A	80742738	3	1	65	1	0	0	0	0	1	0	0	0	15179	1174	41	1	382	1	SSBP2	5	80742738	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	189065	80742738	100172522	435	19468										
GPR98	84059	broad.mit.edu	37	chr5	89923556	89923556	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattcaacagtgttttgtttGaaaggacagttataattgat	8	4	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:89923556G>C	uc003kju.2	+	7	1297	c.1201G>C	c.(1201-1203)GAA>CAA	p.E401Q	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	401	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTTTTGTTTGAAAGGACAGT	0.299													0	0	0	1	0	8	39										C	89923556	G	C	89923556	3	2	65	1	0	0	0	0	1	0	0	0	6721	1291	45	1	1227	1	GPR98	5	89923556	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9180818	89923556	90991704	436	19469										
MCTP1	79772	broad.mit.edu	37	chr5	94278072	94278072	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgtttaactccaattgtgtCagatccagaaaggctgagcc	9	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:94278072C>G	uc003kkx.2	-	4	1041	c.1041G>C	c.(1039-1041)CTG>CTC	p.L347L	MCTP1_uc003kkv.2_Silent_p.L126L|MCTP1_uc003kkw.2_Silent_p.L126L|MCTP1_uc003kkz.2_Silent_p.L8L	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	347					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CCAATTGTGTCAGATCCAGAA	0.313													0	0	0	1	0	18	45										G	94278072	C	G	94278072	2	3	65	1	0	0	0	0	0	0	0	1	9400	813	29	1		1	MCTP1	5	94278072	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4354516	94278072	86637188	437	19470										
ARSK	153642	broad.mit.edu	37	chr5	94936565	94936565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acatagatattgctggaattCctctgcctcagaacctgagt	8	10	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:94936565C>T	uc003kld.2	+	7	1269	c.1111C>T	c.(1111-1113)CCT>TCT	p.P371S	ARSK_uc010jbg.2_Missense_Mutation_p.P212S|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	371						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TGCTGGAATTCCTCTGCCTCA	0.333													0	0	0	1	0	20	69										T	94936565	C	T	94936565	3	4	65	1	0	0	0	0	1	0	0	0	996	855	30	1	1137	1	ARSK	5	94936565	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	658493	94936565	85978695	438	19471										
ERAP2	64167	broad.mit.edu	37	chr5	96237258	96237258	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaaagagatgatgactacaTggactctccagaaaggaatc	9	8	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:96237258T>G	uc003kmq.2	+	11	2331	c.1621T>G	c.(1621-1623)TGG>GGG	p.W541G	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.W541G|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.W490G|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	541	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GATGACTACATGGACTCTCCA	0.498													0	0	0	1	0	25	76										G	96237258	T	G	96237258	3	3	65	1	0	0	0	0	1	0	0	0	5204	1464	51	5	1659	5	ERAP2	5	96237258	Missense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	1300693	96237258	84678002	439	19472										
DCP2	167227	broad.mit.edu	37	chr5	112321592	112321592	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaatccgagtgtgttttcaGattgaacttgcccattggtt	10	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:112321592G>T	uc003kqh.2	+	2	312	c.114G>T	c.(112-114)CAG>CAT	p.Q38H	DCP2_uc011cwa.1_Intron	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	38					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		TGTGTTTTCAGATTGAACTTG	0.373													1	0	4.2108e-06	1	4.32054e-06	32	86										T	112321592	G	T	112321592	3	4	65	1	0	0	0	0	1	0	0	0	4300	933	33	3	120	3	DCP2	5	112321592	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	16084334	112321592	68593668	440	19473										
DMXL1	1657	broad.mit.edu	37	chr5	118500366	118500366	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcatcttacgcaaatgcataGaaaaagtaagtgttttattt	7	5	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:118500366G>C	uc003ksd.2	+	20	5048	c.4867G>C	c.(4867-4869)GAA>CAA	p.E1623Q	DMXL1_uc010jcl.1_Missense_Mutation_p.E1623Q	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1623										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CAAATGCATAGAAAAAGTAAG	0.408													0	0	0	1	0	21	83										C	118500366	G	C	118500366	3	2	65	1	0	0	0	0	1	0	0	0	4594	943	33	1	4945	1	DMXL1	5	118500366	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6178774	118500366	62414894	441	19474										
ZNF608	57507	broad.mit.edu	37	chr5	123982976	123982976	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcttttcagcatcttcctcaGactccttcttgatcttcatt	3	13	7	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:123982976G>C	uc003ktq.1	-	4	3224	c.3101C>G	c.(3100-3102)TCT>TGT	p.S1034C	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.S1034C|ZNF608_uc003ktt.1_Missense_Mutation_p.S1034C|ZNF608_uc003ktp.1_5'Flank	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1034						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ATCTTCCTCAGACTCCTTCTT	0.493													0	0	0	1	0	43	134										C	123982976	G	C	123982976	3	2	65	1	0	0	0	0	1	0	0	0	18031	942	33	1	1461	1	ZNF608	5	123982976	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5482610	123982976	56932284	442	19475										
FNIP1	96459	broad.mit.edu	37	chr5	130982830	130982830	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaacacgcatctgccccctCaggtattcagacagcatttt	7	13	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:130982830C>G	uc003kvs.1	-	17	3517	c.3375G>C	c.(3373-3375)CTG>CTC	p.L1125L	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Silent_p.L1097L	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	1125					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TCTGCCCCCTCAGGTATTCAG	0.468													0	0	0	1	0	34	128										G	130982830	C	G	130982830	2	3	65	1	0	0	0	0	0	0	0	1	5975	813	29	1		1	FNIP1	5	130982830	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6999854	130982830	49932430	443	19476										
FSTL4	23105	broad.mit.edu	37	chr5	132652162	132652162	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgcccacctgagccagttCggagctgctgaggtggccat	14	12	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:132652162C>G	uc003kyn.1	-	5	810	c.592G>C	c.(592-594)GAA>CAA	p.E198Q		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	198	Potential.|EF-hand.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGCCAGTTCGGAGCTGCTG	0.557													0	0	0	1	0	17	73										G	132652162	C	G	132652162	3	3	65	1	0	0	0	0	1	0	0	0	6079	893	31	1	1984	1	FSTL4	5	132652162	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1669332	132652162	48263098	444	19477										
SEC24A	10802	broad.mit.edu	37	chr5	134060783	134060783	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acagcaacaagtgaataaatGaatgaatgaagaaatttgac	8	4	0	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:134060783G>A	uc003kzs.2	+	23	3569	c.3281G>A	c.(3280-3282)TGA>TAA	p.*1094*	SEC24A_uc011cxu.1_Silent_p.*858*	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	1094					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTGAATAAATGAATGAATGAA	0.308													0	0	0	1	0	6	18										A	134060783	G	A	134060783	2	1	65	1	0	0	0	0	0	0	0	1	13994	1285	45	1		1	SEC24A	5	134060783	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1408621	134060783	46854477	445	19478										
CATSPER3	347732	broad.mit.edu	37	chr5	134346119	134346119	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagaactttaagaagaccttGagccacactgacccaatggt	9	10	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:134346119G>C	uc003lag.2	+	7	1061	c.993G>C	c.(991-993)TTG>TTC	p.L331F		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	331					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGAAGACCTTGAGCCACACTG	0.463													0	0	0	1	0	39	69										C	134346119	G	C	134346119	3	2	65	1	0	0	0	0	1	0	0	0	2689	1281	45	1	1019	1	CATSPER3	5	134346119	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	285336	134346119	46569141	446	19479										
TIFAB	497189	broad.mit.edu	37	chr5	134785491	134785491	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaggcgagggagctgcagctGgaggtgggcgtcctgccccc	19	12	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:134785491G>A	uc003law.3	-	2	340	c.139C>T	c.(139-141)CAG>TAG	p.Q47*	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	47	FHA.										0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCTGCAGCTGGAGGTGGGCG	0.672													0	0	0	1	0	27	75										A	134785491	G	A	134785491	4	1	65	1	0	0	0	0	0	1	0	0	15892	1357	47	2	350	2	TIFAB	5	134785491	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	439372	134785491	46129769	447	19480										
SPOCK1	6695	broad.mit.edu	37	chr5	136403437	136403437	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttgtgctttggtggctcagGctctgggagacagggacagg	17	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:136403437G>A	uc003lbo.2	-	5	747	c.556C>T	c.(556-558)CCT>TCT	p.P186S	SPOCK1_uc003lbp.2_Missense_Mutation_p.P186S	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	186					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTGGCTCAGGCTCTGGGAGA	0.547													0	0	0	1	0	37	92										A	136403437	G	A	136403437	3	1	65	1	0	0	0	0	1	0	0	0	15078	1203	42	2	787	2	SPOCK1	5	136403437	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1617946	136403437	44511823	448	19481										
MATR3	9782	broad.mit.edu	37	chr5	138643397	138643397	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagaggtccactccctttatCttctcaacaccgtggagatg	8	12	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:138643397C>T	uc003ldu.2	+	5	720	c.293C>T	c.(292-294)TCT>TTT	p.S98F	MATR3_uc003lds.2_Missense_Mutation_p.S98F|MATR3_uc010jfb.2_Missense_Mutation_p.S98F|MATR3_uc003ldt.2_Intron|MATR3_uc003ldw.2_Missense_Mutation_p.S98F|MATR3_uc003ldx.2_Missense_Mutation_p.S98F|MATR3_uc010jfc.2_Missense_Mutation_p.S98F|MATR3_uc003ldy.2_Intron|MATR3_uc011czb.1_Intron|MATR3_uc003ldz.2_Missense_Mutation_p.S98F|MATR3_uc003lea.2_Missense_Mutation_p.S98F	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	98						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CTCCCTTTATCTTCTCAACAC	0.443													0	0	0	1	0	24	77										T	138643397	C	T	138643397	3	4	65	1	0	0	0	0	1	0	0	0	9337	913	32	1	295	1	MATR3	5	138643397	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2239960	138643397	42271863	449	19482										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139865267	139865267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaataatgttctgtcagttCccaccacagatgtgtctcag	7	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:139865267C>T	uc003lfs.1	+	13	2216	c.2092C>T	c.(2092-2094)CCC>TCC	p.P698S	ANKHD1_uc003lfq.1_Missense_Mutation_p.P717S|ANKHD1_uc003lfr.2_Missense_Mutation_p.P698S|ANKHD1_uc003lft.1_Missense_Mutation_p.P178S|ANKHD1_uc003lfu.1_Missense_Mutation_p.P178S|ANKHD1_uc003lfv.1_Missense_Mutation_p.P28S	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	698						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGTCAGTTCCCACCACAGA	0.383													0	0	0	1	0	19	41										T	139865267	C	T	139865267	3	4	65	1	0	0	0	0	1	0	0	0	629	855	30	1	2142	1	ANKHD1-EIF4EBP3	5	139865267	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1221870	139865267	41049993	450	19483										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139907508	139907508	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgtcgaggataatgggaaGaggaggatgcaacatcactg							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:139907508G>A	uc003lfs.1	+	28	5262	c.5138G>A	c.(5137-5139)AGA>AAA	p.R1713K	ANKHD1_uc003lfr.2_Missense_Mutation_p.R1713K|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R452K|ANKHD1_uc003lfw.2_Missense_Mutation_p.R351K|ANKHD1_uc010jfl.2_Missense_Mutation_p.R148K|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1713						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATGGGAAGAGGAGGATGC	0.378													0	0	0	1	0	7	29										A	139907508	G	A	139907508	3	1	65	1	0	0	0	0	1	0	0	0	629	942	33	1	5248	1	ANKHD1-EIF4EBP3	5	139907508	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	42241	139907508	41007752	451	19484	97	2								
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139907514	139907514	+	Missense_Mutation	SNP	G	G	T													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaggataatgggaagaggagGatgcaacatcactgcaatac							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:139907514G>T	uc003lfs.1	+	28	5268	c.5144G>T	c.(5143-5145)GGA>GTA	p.G1715V	ANKHD1_uc003lfr.2_Missense_Mutation_p.G1715V|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.G454V|ANKHD1_uc003lfw.2_Missense_Mutation_p.G353V|ANKHD1_uc010jfl.2_Missense_Mutation_p.G150V|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1715						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAAGAGGAGGATGCAACATC	0.378													1	0	0.000274275	1	0.00027772	8	29										T	139907514	G	T	139907514	3	4	65	1	0	0	0	0	1	0	0	0	629	1174	41	3	5254	3	ANKHD1-EIF4EBP3	5	139907514	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6	139907514	41007746	452	19485	97	2								
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139928595	139928595	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agattcccggggtcacaactCctccaacagcccctctctcc	6	19	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:139928595C>G	uc003lfs.1	+	35	7908	c.7784C>G	c.(7783-7785)TCC>TGC	p.S2595C	ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S1351C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.S740C|EIF4EBP3_uc003lfy.1_Missense_Mutation_p.P70A	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2595						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTCACAACTCCTCCAACAGC	0.567													0	0	0	1	0	9	41										G	139928595	C	G	139928595	3	3	65	1	0	0	0	0	1	0	0	0	629	855	30	1	7922	1	ANKHD1-EIF4EBP3	5	139928595	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	21081	139928595	40986665	453	19486										
PCDHA1	56147	broad.mit.edu	37	chr5	140166574	140166574	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagctgctgatcaccgtcctCgacgttaatgataacgcccc	9	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140166574C>T	uc003lhb.2	+	1	699	c.699C>T	c.(697-699)CTC>CTT	p.L233L	PCDHA1_uc003lha.2_Silent_p.L233L|PCDHA1_uc003lgz.2_Silent_p.L233L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	233	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACCGTCCTCGACGTTAATG	0.473													0	0	0	1	0	27	89										T	140166574	C	T	140166574	2	4	65	1	0	0	0	0	0	0	0	1	11519	871	31	1		1	PCDHA1	5	140166574	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	237979	140166574	40748686	454	19487										
PCDHA1	56147	broad.mit.edu	37	chr5	140168060	140168060	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgctcagtgccgcccactGagggtgcgtatgtgccgggc	17	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140168060G>A	uc003lhb.2	+	1	2185	c.2185G>A	c.(2185-2187)GAG>AAG	p.E729K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.E729K	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	729	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGCCCACTGAGGGTGCGTA	0.642													0	0	0	1	0	24	75										A	140168060	G	A	140168060	3	1	65	1	0	0	0	0	1	0	0	0	11519	1291	45	1	2187	1	PCDHA1	5	140168060	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1486	140168060	40747200	455	19488										
PCDHA4	56144	broad.mit.edu	37	chr5	140188377	140188377	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagctgctgcagtttcaggtGaccgctcgcgatgccggcgt	15	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140188377G>T	uc003lhi.2	+	1	1706	c.1605G>T	c.(1603-1605)GTG>GTT	p.V535V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.V535V|PCDHA4_uc011daa.1_Silent_p.V535V	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	535	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTTCAGGTGACCGCTCGCG	0.652													1	0	2.66076e-39	1	2.84745e-39	59	106										T	140188377	G	T	140188377	2	4	65	1	0	0	0	0	0	0	0	1	11526	1277	45	3		3	PCDHA4	5	140188377	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	20317	140188377	40726883	456	19489										
PCDHA8	56140	broad.mit.edu	37	chr5	140220969	140220969	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctactcttgcttctgctcctCgcagcctggaaggtggggag	13	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140220969C>G	uc003lhs.2	+	1	63	c.63C>G	c.(61-63)CTC>CTG	p.L21L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.L21L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	21					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGCTCCTCGCAGCCTGGA	0.567													0	0	0	1	0	50	117										G	140220969	C	G	140220969	2	3	65	1	0	0	0	0	0	0	0	1	11530	871	31	1		1	PCDHA8	5	140220969	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	32592	140220969	40694291	457	19490										
PCDHA11	56138	broad.mit.edu	37	chr5	140248873	140248873	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctggcggagctggtgcagcGcctgttccgggtggcgtcca	18	12	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140248873G>A	uc003lia.2	+	1	1043	c.185G>A	c.(184-186)CGC>CAC	p.R62H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R62H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	62	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGCAGCGCCTGTTCCGG	0.617													0	0	0	1	0	65	257										A	140248873	G	A	140248873	3	1	65	1	0	0	0	0	1	0	0	0	11521	1087	38	2	187	2	PCDHA11	5	140248873	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	27904	140248873	40666387	458	19491										
PCDHA13	56136	broad.mit.edu	37	chr5	140262519	140262519	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatggaggtaaacccgagctGactggcacagttcagctgct	13	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140262519G>A	uc003lif.2	+	1	666	c.666G>A	c.(664-666)CTG>CTA	p.L222L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L222L|PCDHA13_uc003lid.2_Silent_p.L222L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	222	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCCGAGCTGACTGGCACAG	0.453													0	0	0	1	0	18	70										A	140262519	G	A	140262519	2	1	65	1	0	0	0	0	0	0	0	1	11523	1277	45	1		1	PCDHA13	5	140262519	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13646	140262519	40652741	459	19492										
PCDHB8	56128	broad.mit.edu	37	chr5	140559962	140559962	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggccattcttttgggccaGaaatggaacaaaactctaac	9	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140559962G>C	uc011dai.1	+	1	2533	c.2347G>C	c.(2347-2349)GAA>CAA	p.E783Q	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	783	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTTGGGCCAGAAATGGAACA	0.378													0	0	0	1	0	21	98										C	140559962	G	C	140559962	3	2	65	1	0	0	0	0	1	0	0	0	11548	943	33	1	2349	1	PCDHB8	5	140559962	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	297443	140559962	40355298	460	19493										
PCDHB15	56121	broad.mit.edu	37	chr5	140625700	140625700	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccatgtttccactcgcacccGaggggatggcaggaaatacc	11	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140625700G>C	uc003lje.2	+	1	554	c.554G>C	c.(553-555)CGA>CCA	p.R185P		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	185	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGCACCCGAGGGGATGGC	0.517													0	0	0	1	0	27	62										C	140625700	G	C	140625700	3	2	65	1	0	0	0	0	1	0	0	0	11540	1058	37	1	556	1	PCDHB15	5	140625700	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	65738	140625700	40289560	461	19494										
PCDHGC3	5098	broad.mit.edu	37	chr5	140857358	140857358	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgtgaacatatttgtcactGatcgcaatgacaatgccccc	8	12	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:140857358G>A	uc003lkv.1	+	1	1790	c.1675G>A	c.(1675-1677)GAT>AAT	p.D559N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lku.1_Missense_Mutation_p.D559N|PCDHGC3_uc003lkw.1_Intron	NM_002588	NP_002579	Q9UN70	PCDGK_HUMAN	protocadherin gamma subfamily C, 3 isoform 1	559	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTGTCACTGATCGCAATGA	0.557											OREG0016865	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	26	80										A	140857358	G	A	140857358	3	1	65	1	0	0	0	0	1	0	0	0	11569	1290	45	1	1677	1	PCDHGC3	5	140857358	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	231658	140857358	40057902	462	19495										
SH3RF2	153769	broad.mit.edu	37	chr5	145393552	145393552	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcagcaccccagtgctcatCagctccagcaacccctctgt	6	18	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:145393552C>T	uc003lnt.2	+	5	1225	c.987C>T	c.(985-987)ATC>ATT	p.I329I	SH3RF2_uc011dbl.1_Silent_p.I329I	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	329							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGTGCTCATCAGCTCCAGCA	0.562													0	0	0	1	0	47	142										T	145393552	C	T	145393552	2	4	65	1	0	0	0	0	0	0	0	1	14259	816	29	1		1	SH3RF2	5	145393552	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4536194	145393552	35521708	463	19496										
PPP2R2B	5521	broad.mit.edu	37	chr5	145969658	145969658	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttttctccgcttgccccccAcacacacttttcggggtttg	7	16	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:145969658A>C	uc003loe.2	-	9	1709	c.1184T>G	c.(1183-1185)GTG>GGG	p.V395G	PPP2R2B_uc010jgm.2_Missense_Mutation_p.V384G|PPP2R2B_uc003log.3_Missense_Mutation_p.V395G|PPP2R2B_uc003lof.3_Missense_Mutation_p.V395G|PPP2R2B_uc003loi.3_Missense_Mutation_p.V398G|PPP2R2B_uc003loh.3_Missense_Mutation_p.V395G|PPP2R2B_uc003loj.3_Missense_Mutation_p.V375G|PPP2R2B_uc003lok.3_Missense_Mutation_p.V384G|PPP2R2B_uc011dbu.1_Missense_Mutation_p.V401G|PPP2R2B_uc011dbv.1_Missense_Mutation_p.V453G	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	395					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity	p.V398G(1)		ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTGCCCCCCACACACACTTT	0.488													0	0	0	1	0	37	133										C	145969658	A	C	145969658	3	2	65	1	0	0	0	0	1	0	0	0	12385	159	6	5	151	5	PPP2R2B	5	145969658	Missense_Mutation	SNP	A	TCGA-DK-A3WW-01A-22D-A23M-08	576106	145969658	34945602	464	19497										
ADRB2	154	broad.mit.edu	37	chr5	148206577	148206577	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcacagccattgccaagttCgagcgtctgcagacggtcac	10	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:148206577C>T	uc003lpr.1	+	1	422	c.183C>T	c.(181-183)TTC>TTT	p.F61F	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	61	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	TTGCCAAGTTCGAGCGTCTGC	0.582													0	0	0	1	0	24	75										T	148206577	C	T	148206577	2	4	65	1	0	0	0	0	0	0	0	1	341	883	31	1		1	ADRB2	5	148206577	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2236919	148206577	32708683	465	19498										
PDE6A	5145	broad.mit.edu	37	chr5	149264428	149264428	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttggccagtgggttctggGatctgaatgagaaagagaga	16	5	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:149264428G>C	uc003lrg.3	-	15	1961	c.1841C>G	c.(1840-1842)TCC>TGC	p.S614C		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	614					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TGGGTTCTGGGATCTGAATGA	0.463													0	0	0	1	0	16	56										C	149264428	G	C	149264428	3	2	65	1	0	0	0	0	1	0	0	0	11645	1174	41	1	773	1	PDE6A	5	149264428	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1057851	149264428	31650832	466	19499										
SLC6A7	6534	broad.mit.edu	37	chr5	149576666	149576666	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atctactacaacatgatcatCgcctacgtgctcttctacct	4	14	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:149576666C>A	uc003lrr.2	+	4	782	c.411C>A	c.(409-411)ATC>ATA	p.I137I		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	137	Helical; Name=3; (Potential).					integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	ACATGATCATCGCCTACGTGC	0.622													1	0	1.2644e-06	1	1.30368e-06	22	65										A	149576666	C	A	149576666	2	1	65	1	0	0	0	0	0	0	0	1	14689	874	31	3		3	SLC6A7	5	149576666	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	312238	149576666	31338594	467	19500										
NDST1	3340	broad.mit.edu	37	chr5	149932879	149932879	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acttggctacgagaggacctCcagaacaccaggtagccgtg	12	12	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:149932879C>G	uc003lsk.3	+	15	3136	c.2634C>G	c.(2632-2634)CTC>CTG	p.L878L	NDST1_uc011dcj.1_Silent_p.L821L	NM_001543	NP_001534	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan	878	Heparan sulfate N-sulfotransferase 1.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGAGGACCTCCAGAACACCA	0.567													0	0	0	1	0	66	375										G	149932879	C	G	149932879	2	3	65	1	0	0	0	0	0	0	0	1	10255	842	30	1		1	NDST1	5	149932879	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	356213	149932879	30982381	468	19501										
ANXA6	309	broad.mit.edu	37	chr5	150512094	150512094	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcccctcggatgctggcttCaatcggcttccctgtggtct	10	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:150512094C>T	uc003ltl.1	-	10	831	c.679G>A	c.(679-681)GAA>AAA	p.E227K	ANXA6_uc011dcp.1_Missense_Mutation_p.E195K|ANXA6_uc003ltm.1_Missense_Mutation_p.E227K|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	227	Annexin 3.			IE -> MK (in Ref. 2; AAA35656).		melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGCTGGCTTCAATCGGCTTC	0.542													0	0	0	1	0	10	26										T	150512094	C	T	150512094	3	4	65	1	0	0	0	0	1	0	0	0	722	835	29	1	1410	1	ANXA6	5	150512094	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	579215	150512094	30403166	469	19502										
LARP1	23367	broad.mit.edu	37	chr5	154181594	154181594	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagtccagattttcccacCtgacctctctgcctcagcag	8	15	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:154181594C>G	uc003lvp.2	+	11	2173	c.1744C>G	c.(1744-1746)CTG>GTG	p.L582V	LARP1_uc003lvo.2_Missense_Mutation_p.L505V|LARP1_uc010jie.1_Missense_Mutation_p.L377V	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	582							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATTTTCCCACCTGACCTCTCT	0.498													0	0	0	1	0	16	62										G	154181594	C	G	154181594	3	3	65	1	0	0	0	0	1	0	0	0	8628	680	24	4	1555	4	LARP1	5	154181594	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3669500	154181594	26733666	470	19503										
ATP10B	23120	broad.mit.edu	37	chr5	159992533	159992533	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcacatatcagtctgtcctCttgagtaggccattatcctg	9	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:159992533C>G	uc003lym.1	-	26	5160	c.4313G>C	c.(4312-4314)AGA>ACA	p.R1438T	ATP10B_uc010jit.1_Missense_Mutation_p.R688T	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1438	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTCTGTCCTCTTGAGTAGGC	0.537													0	0	0	1	0	47	116										G	159992533	C	G	159992533	3	3	65	1	0	0	0	0	1	0	0	0	1117	913	32	1	76	1	ATP10B	5	159992533	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5810939	159992533	20922727	471	19504										
SLIT3	6586	broad.mit.edu	37	chr5	168175380	168175380	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgcatcgcaccactgtctCcatacaggtgcactgctccg	9	16	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:168175380C>G	uc003mab.2	-	20	2617	c.2197G>C	c.(2197-2199)GAG>CAG	p.E733Q	SLIT3_uc010jjg.2_Missense_Mutation_p.E733Q	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	733	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACCACTGTCTCCATACAGGTG	0.632													0	0	0	1	0	28	94										G	168175380	C	G	168175380	3	3	65	1	0	0	0	0	1	0	0	0	14741	864	30	1	2442	1	SLIT3	5	168175380	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8182847	168175380	12739880	472	19505										
C5orf25	375484	broad.mit.edu	37	chr5	175772332	175772332	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctgatccagatgctggggGagcctcttgtcccccaactc	11	15	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:175772332G>T	uc003mds.3	+	12	2910	c.2503G>T	c.(2503-2505)GAG>TAG	p.E835*	C5orf25_uc003mdt.3_Nonsense_Mutation_p.E420*|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Nonsense_Mutation_p.E296*			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	835											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		GATGCTGGGGGAGCCTCTTGT	0.537													1	0	5.45024e-15	1	5.74907e-15	26	56										T	175772332	G	T	175772332	4	4	65	1	0	0	0	0	0	1	0	0	2288	1175	41	3	1292	3	C5orf25	5	175772332	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7596952	175772332	5142928	473	19506										
SNCB	6620	broad.mit.edu	37	chr5	176047844	176047844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcatactcctgatattcctCctgcatcaccgggatggggg	10	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:176047844C>T	uc003mep.2	-	7	816	c.373G>A	c.(373-375)GAG>AAG	p.E125K	SNCB_uc003meq.2_Missense_Mutation_p.E125K	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	125							calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGATATTCCTCCTGCATCACC	0.622													0	0	0	1	0	14	54										T	176047844	C	T	176047844	3	4	65	1	0	0	0	0	1	0	0	0	14842	869	30	1	35	1	SNCB	5	176047844	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	275512	176047844	4867416	474	19507										
MGAT1	4245	broad.mit.edu	37	chr5	180219580	180219580	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgatggggaagagctcagccGagggccgataatgcagcagc	16	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr5:180219580G>A	uc003mmg.3	-	2	887	c.392C>T	c.(391-393)TCG>TTG	p.S131L	MGAT1_uc010jlf.2_Missense_Mutation_p.S131L|MGAT1_uc010jlg.2_Missense_Mutation_p.S131L|MGAT1_uc003mmh.3_Missense_Mutation_p.S131L|MGAT1_uc010jlh.2_Missense_Mutation_p.S131L|MGAT1_uc003mmi.3_Missense_Mutation_p.S131L	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	131	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGCTCAGCCGAGGGCCGATA	0.672													0	0	0	1	0	19	65										A	180219580	G	A	180219580	3	1	65	1	0	0	0	0	1	0	0	0	9542	1059	37	1	949	1	MGAT1	5	180219580	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4171736	180219580	695680	475	19508										
IRF4	3662	broad.mit.edu	37	chr6	397158	397158	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaccgaagctggagggactaCgtcccggatcagccacaccc	12	15	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:397158C>T	uc003msz.3	+	5	656	c.543C>T	c.(541-543)TAC>TAT	p.Y181Y	IRF4_uc010jne.1_Silent_p.Y181Y|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Silent_p.Y180Y|IRF4_uc003mtc.1_Silent_p.Y11Y	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	181					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GGAGGGACTACGTCCCGGATC	0.572			T	IGH@	MM 								0	0	0	1	0	42	179										T	397158	C	T	397158	2	4	65	1	0	0	0	0	0	0	0	1	7832	547	19	2		2	IRF4	6	397158	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		397158	170717909	476	19509										
RPP40	10799	broad.mit.edu	37	chr6	5002362	5002362	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tataaaggtactgatgaattCaggtgtaattaattcatgaa	8	3	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:5002362C>T	uc003mwl.2	-	2	276	c.241G>A	c.(241-243)GAA>AAA	p.E81K	uc003mwn.1_5'Flank|RPP40_uc003mwm.2_Missense_Mutation_p.E81K	NM_006638	NP_006629	O75818	RPP40_HUMAN	ribonuclease P 40kDa subunit	81					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0895)				CTGATGAATTCAGGTGTAATT	0.403													0	0	0	1	0	21	103										T	5002362	C	T	5002362	3	4	65	1	0	0	0	0	1	0	0	0	13614	835	29	1	878	1	RPP40	6	5002362	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4605204	5002362	166112705	477	19510										
F13A1	2162	broad.mit.edu	37	chr6	6152170	6152170	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catgtcagaaccaactacctGagtgccacggacctaagaga	9	12	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:6152170G>A	uc003mwv.2	-	14	2044	c.1921C>T	c.(1921-1923)CAG>TAG	p.Q641*	F13A1_uc011dib.1_Nonsense_Mutation_p.Q578*	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	641					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CCAACTACCTGAGTGCCACGG	0.438													0	0	0	1	0	22	23										A	6152170	G	A	6152170	4	1	65	1	0	0	0	0	0	1	0	0	5340	1299	45	1	285	1	F13A1	6	6152170	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1149808	6152170	164962897	478	19511										
SSR1	6745	broad.mit.edu	37	chr6	7303849	7303849	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcaggttcaccagacacatCttcttcctctttatcttcta	3	13	7	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:7303849C>T	uc003mxf.3	-	3	402	c.214G>A	c.(214-216)GAT>AAT	p.D72N	SSR1_uc003mxg.3_Missense_Mutation_p.D72N|SSR1_uc010jny.2_Missense_Mutation_p.D72N	NM_003144	NP_003135	P43307	SSRA_HUMAN	signal sequence receptor, alpha precursor	72	Lumenal (Potential).				cotranslational protein targeting to membrane|positive regulation of cell proliferation	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Ovarian(93;0.0398)					CCAGACACATCTTCTTCCTCT	0.294													0	0	0	1	0	55	57										T	7303849	C	T	7303849	3	4	65	1	0	0	0	0	1	0	0	0	15189	913	32	1	670	1	SSR1	6	7303849	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1151679	7303849	163811218	479	19512										
MUTED	63915	broad.mit.edu	37	chr6	8041426	8041426	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtgtctctacatttgggaaGagtatgttcatttgtttcat	9	5	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:8041426G>A	uc003mxy.2	-	3	309	c.271C>T	c.(271-273)CTT>TTT	p.L91F	TXNDC5_uc003mxw.2_Silent_p.L7L|MUTED_uc010joc.2_Missense_Mutation_p.L27F|MUTED_uc010job.2_RNA	NM_201280	NP_958437	Q8TDH9	MUTED_HUMAN	muted	91						BLOC-1 complex	protein binding				0	Ovarian(93;0.0398)					CATTTGGGAAGAGTATGTTCA	0.368													0	0	0	1	0	28	77										A	8041426	G	A	8041426	3	1	65	1	0	0	0	0	1	0	0	0	9992	942	33	1	304	1	MUTED	6	8041426	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	737577	8041426	163073641	480	19513										
GCM2	9247	broad.mit.edu	37	chr6	10874680	10874680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgggttataataagggcGagtggccatggcctgaaact	13	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:10874680G>A	uc003mzn.3	-	5	1141	c.1069C>T	c.(1069-1071)CGC>TGC	p.R357C	SYCP2L_uc011dim.1_Intron	NM_004752	NP_004743	O75603	GCM2_HUMAN	glial cells missing homolog 2	357					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TAATAAGGGCGAGTGGCCATG	0.532													0	0	0	1	0	89	78										A	10874680	G	A	10874680	3	1	65	1	0	0	0	0	1	0	0	0	6298	1058	37	1	455	1	GCM2	6	10874680	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2833254	10874680	160240387	481	19514										
HIVEP1	3096	broad.mit.edu	37	chr6	12124515	12124515	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggatctgcaggcagaaacatCaaactccagctctaccaacg	8	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:12124515C>G	uc003nac.2	+	4	4666	c.4487C>G	c.(4486-4488)TCA>TGA	p.S1496*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1496					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCAGAAACATCAAACTCCAGC	0.448													0	0	0	1	0	21	71										G	12124515	C	G	12124515	4	3	65	1	0	0	0	0	0	1	0	0	7186	838	29	1	4497	1	HIVEP1	6	12124515	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1249835	12124515	158990552	482	19515										
KIF13A	63971	broad.mit.edu	37	chr6	17781078	17781078	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcctttcattctgtggtgtGaccctattcaagtgaacaga	8	9	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:17781078G>A	uc003ncg.3	-	31	3834	c.3729C>T	c.(3727-3729)GTC>GTT	p.V1243V	KIF13A_uc003ncf.2_Silent_p.V1230V|KIF13A_uc003nch.3_Silent_p.V1243V|KIF13A_uc003nci.3_Silent_p.V1230V|KIF13A_uc003nce.1_5'Flank	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1243					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCTGTGGTGTGACCCTATTCA	0.448													0	0	0	1	0	18	54										A	17781078	G	A	17781078	2	1	65	1	0	0	0	0	0	0	0	1	8274	1277	45	1		1	KIF13A	6	17781078	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5656563	17781078	153333989	483	19516										
DEK	7913	broad.mit.edu	37	chr6	18249902	18249902	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcctcttcactttctttatCttcatcatctgaagactctt	2	13	8	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:18249902C>G	uc003ncr.1	-	7	935	c.742G>C	c.(742-744)GAT>CAT	p.D248H	DEK_uc011djf.1_Missense_Mutation_p.D214H|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	248	Asp/Glu-rich (acidic).				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			CTTTCTTTATCTTCATCATCT	0.333			T	NUP214	AML								0	0	0	1	0	7	23										G	18249902	C	G	18249902	3	3	65	1	0	0	0	0	1	0	0	0	4424	913	32	1	405	1	DEK	6	18249902	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	468824	18249902	152865165	484	19517										
CDKAL1	54901	broad.mit.edu	37	chr6	21201376	21201376	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaccctgcgttcatggggaaGatggttgaagtggacatcta	13	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:21201376G>C	uc003ndc.1	+	15	1593	c.1419G>C	c.(1417-1419)AAG>AAC	p.K473N	CDKAL1_uc003ndd.1_Missense_Mutation_p.K473N|CDKAL1_uc003nde.1_Missense_Mutation_p.K382N|CDKAL1_uc003ndf.1_Intron|CDKAL1_uc003ndg.2_RNA	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	473	TRAM.				RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			TCATGGGGAAGATGGTTGAAG	0.363													0	0	0	1	0	31	109										C	21201376	G	C	21201376	3	2	65	1	0	0	0	0	1	0	0	0	3152	933	33	1	1469	1	CDKAL1	6	21201376	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2951474	21201376	149913691	485	19518										
DCDC2	51473	broad.mit.edu	37	chr6	24175047	24175047	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctggccttggtggtctttGagggtctacatcagcctaga	12	9	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:24175047G>A	uc003ndx.2	-	10	1644	c.1342C>T	c.(1342-1344)CAA>TAA	p.Q448*	DCDC2_uc003ndy.2_Nonsense_Mutation_p.Q448*|DCDC2_uc003ndw.2_Nonsense_Mutation_p.Q199*	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	448					cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				GGTGGTCTTTGAGGGTCTACA	0.353													0	0	0	1	0	12	72										A	24175047	G	A	24175047	4	1	65	1	0	0	0	0	0	1	0	0	4285	1299	45	1	92	1	DCDC2	6	24175047	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2973671	24175047	146940020	486	19519										
HIST1H3B	8358	broad.mit.edu	37	chr6	26031895	26031895	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catttacgctctttctccgcGaatgcggcgagcgagctgga	12	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:26031895G>C	uc003nfs.1	-	1	394	c.394C>G	c.(394-396)CGC>GGC	p.R132G		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	132					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						CTTTCTCCGCGAATGCGGCGA	0.478													0	0	0	1	0	32	57										C	26031895	G	C	26031895	3	2	65	1	0	0	0	0	1	0	0	0	7156	1058	37	1	20	1	HIST1H3B	6	26031895	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1856848	26031895	145083172	487	19520										
HIST1H3C	8352	broad.mit.edu	37	chr6	26045914	26045914	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagagctctgcggtgatggcGctgcaggaggcttgtgaggc	18	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:26045914G>A	uc003nfv.2	+	1	276	c.276G>A	c.(274-276)GCG>GCA	p.A92A	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	92					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CGGTGATGGCGCTGCAGGAGG	0.582													0	0	0	1	0	22	80										A	26045914	G	A	26045914	2	1	65	1	0	0	0	0	0	0	0	1	7157	1074	38	2		2	HIST1H3C	6	26045914	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	14019	26045914	145069153	488	19521										
HIST1H2AE	3012	broad.mit.edu	37	chr6	26217568	26217568	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgctgcctaagaagacggaGagccaccataaggccaaggg	13	10	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:26217568G>C	uc003nha.1	+	1	421	c.366G>C	c.(364-366)GAG>GAC	p.E122D	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	122					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				AGAAGACGGAGAGCCACCATA	0.542													0	0	0	1	0	19	59										C	26217568	G	C	26217568	3	2	65	1	0	0	0	0	1	0	0	0	7132	933	33	1	368	1	HIST1H2AE	6	26217568	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	171654	26217568	144897499	489	19522										
HIST1H4H	8365	broad.mit.edu	37	chr6	26285723	26285723	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttccacctttaccacggccaGacatgactaagcaacttcta	5	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:26285723G>C	uc003nhm.2	-	1	5	c.5C>G	c.(4-6)TCT>TGT	p.S2C	HIST1H4H_uc003nhl.1_RNA	NM_003543	NP_003534	P62805	H4_HUMAN	histone cluster 1, H4h	2					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding	p.S2C(1)		ovary(2)	2						ACCACGGCCAGACATGACTAA	0.473										HNSCC(76;0.23)			0	0	0	1	0	17	71										C	26285723	G	C	26285723	3	2	65	1	0	0	0	0	1	0	0	0	7172	942	33	1	310	1	HIST1H4H	6	26285723	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	68155	26285723	144829344	490	19523										
BTN2A1	11120	broad.mit.edu	37	chr6	26465586	26465586	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caagagaaattgctctaaagGaactggagaaagaacgtgtg	12	5	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:26465586G>A	uc003nib.1	+	5	1098	c.886G>A	c.(886-888)GAA>AAA	p.E296K	BTN2A1_uc003nic.1_Missense_Mutation_p.E296K|BTN2A1_uc003nid.1_Missense_Mutation_p.E144K|BTN2A1_uc011dko.1_Missense_Mutation_p.E235K|BTN2A1_uc010jqk.1_Missense_Mutation_p.E56K	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	296	Cytoplasmic (Potential).				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						TGCTCTAAAGGAACTGGAGAA	0.299													0	0	0	1	0	58	69										A	26465586	G	A	26465586	3	1	65	1	0	0	0	0	1	0	0	0	1560	1175	41	1	900	1	BTN2A1	6	26465586	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	179863	26465586	144649481	491	19524										
ZNF184	7738	broad.mit.edu	37	chr6	27420524	27420524	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atatggtttatctccagtatGaattctttgatggtttataa	7	4	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:27420524G>C	uc003njj.2	-	5	1625	c.814C>G	c.(814-816)CAT>GAT	p.H272D	ZNF184_uc010jqv.2_Missense_Mutation_p.H272D|ZNF184_uc003nji.2_Missense_Mutation_p.H272D	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	272	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCCAGTATGAATTCTTTGA	0.378													0	0	0	1	0	17	85										C	27420524	G	C	27420524	3	2	65	1	0	0	0	0	1	0	0	0	17748	1290	45	1	1445	1	ZNF184	6	27420524	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	954938	27420524	143694543	492	19525										
HIST1H4L	8368	broad.mit.edu	37	chr6	27840978	27840978	+	Nonstop_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgtaagtaagtaaaacactCagccgccaaagccatacagg	9	10	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:27840978C>A	uc003njz.2	-	1	312	c.311G>T	c.(310-312)TGA>TTA	p.*104L	HIST1H3I_uc003njy.2_5'Flank	NM_003546	NP_003537	P62805	H4_HUMAN	histone cluster 1, H4l	104					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)|breast(1)	2						GTAAAACACTCAGCCGCCAAA	0.512													1	0	2.17888e-05	1	2.22085e-05	9	57										A	27840978	C	A	27840978	4	1	65	1	0	0	0	0	0	0	0	0	7176	837	29	3	4	3	HIST1H4L	6	27840978	Nonstop_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	420454	27840978	143274089	493	19526										
HLA-A	3105	broad.mit.edu	37	chr6	29910640	29910640	+	Frame_Shift_Del	DEL	C	C	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacacgcagttcgtgcggttCgacagcgacgccgcgagcca					rs3173429		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:29910640delC	uc003nol.2	+	2	180	c.180delC	c.(178-180)TTCfs	p.F60fs	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Frame_Shift_Del_p.F60fs|HLA-A_uc003noo.2_Frame_Shift_Del_p.F60fs|HLA-A_uc010jrr.2_Frame_Shift_Del_p.F60fs|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Frame_Shift_Del_p.F32fs|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	60	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCGTGCGGTTCGACAGCGACG	0.667									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)								19	68	---	---								-	29910640	C	-	29910640	7	5	65	1	0	1	0	1	0	0	0	0	7195	883	31	0	186	0	HLA-A	6	29910640	Frame_Shift_Del	DEL	C	TCGA-DK-A3WW-01A-22D-A23M-08	2069662	29910640	141204427	494	19527										
C6orf136	221545	broad.mit.edu	37	chr6	30619214	30619214	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacttgctctttttgcggttCtacaagcgtgacaaagacga	9	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:30619214C>T	uc003nqw.3	+	4	928	c.735C>T	c.(733-735)TTC>TTT	p.F245F	C6orf136_uc003nqx.3_Silent_p.F426F|C6orf136_uc011dmn.1_Silent_p.F111F	NM_001109938	NP_001103408	Q5SQH8	CF136_HUMAN	hypothetical protein LOC221545 isoform 1	245											0						TTTTGCGGTTCTACAAGCGTG	0.448													0	0	0	1	0	103	366										T	30619214	C	T	30619214	2	4	65	1	0	0	0	0	0	0	0	1	2331	912	32	1		1	C6orf136	6	30619214	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	708574	30619214	140495853	495	19528										
KIAA1949	170954	broad.mit.edu	37	chr6	30653003	30653003	+	Frame_Shift_Del	DEL	A	A	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcttgtctttcttctcctgAcctcagcctccactctgttg							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:30653003delA	uc003nra.2	-	2	1024	c.793delT	c.(793-795)TCAfs	p.S265fs	KIAA1949_uc003nrb.3_Frame_Shift_Del_p.S265fs	NM_001134870	NP_001128342	Q6NYC8	PHTNS_HUMAN	phostensin	265						cytoplasm|cytoskeleton	actin binding				0						TCTTCTCCTGACCTCAGCCTC	0.522																		9	396	---	---								-	30653003	A	-	30653003	7	5	65	1	0	1	0	1	0	0	0	0	8263	275	10	0	1060	0	KIAA1949	6	30653003	Frame_Shift_Del	DEL	A	TCGA-DK-A3WW-01A-22D-A23M-08	33789	30653003	140462064	496	19529										
TNF	7124	broad.mit.edu	37	chr6	31544355	31544355	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccctctggcccaggcagtCagtaagtgtctccaaacctc	9	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:31544355C>T	uc003nui.2	+	2	400	c.231C>T	c.(229-231)GTC>GTT	p.V77V	TNF_uc003nuj.2_5'UTR	NM_000594	NP_000585	P01375	TNFA_HUMAN	tumor necrosis factor alpha	77	Extracellular (Potential).	Cleavage; by ADAM17.			activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			ovary(1)|pancreas(1)|skin(1)	3		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	CCCAGGCAGTCAGTAAGTGTC	0.502									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				0	0	0	1	0	38	112										T	31544355	C	T	31544355	2	4	65	1	0	0	0	0	0	0	0	1	16268	840	29	1		1	TNF	6	31544355	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	891352	31544355	139570712	497	19530										
TNXB	7148	broad.mit.edu	37	chr6	32010104	32010104	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagtcctcccagtccctccaGaagtctgtctgtccatccat	6	16	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:32010104G>A	uc003nzl.2	-	41	12442	c.12240C>T	c.(12238-12240)TTC>TTT	p.F4080F	TNXB_uc003nzg.1_Silent_p.F511F|TNXB_uc003nzh.1_Silent_p.F549F	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	4127	Fibrinogen C-terminal.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGTCCCTCCAGAAGTCTGTCT	0.612													0	0	0	1	0	9	45										A	32010104	G	A	32010104	2	1	65	1	0	0	0	0	0	0	0	1	16343	933	33	1		1	TNXB	6	32010104	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	465749	32010104	139104963	498	19531										
TNXB	7148	broad.mit.edu	37	chr6	32021477	32021477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcttgggtggtctctgcttCatcctctggagctggacaga	13	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:32021477C>T	uc003nzl.2	-	25	8675	c.8473G>A	c.(8473-8475)GAA>AAA	p.E2825K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTCTCTGCTTCATCCTCTGGA	0.587													0	0	0	1	0	16	62										T	32021477	C	T	32021477	3	4	65	1	0	0	0	0	1	0	0	0	16343	835	29	1	6320	1	TNXB	6	32021477	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11373	32021477	139093590	499	19532										
NOTCH4	4855	broad.mit.edu	37	chr6	32170230	32170230	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctttaggagctggtggggtCaggcagtcaggacccccata	14	11	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:32170230C>T	uc003obb.2	-	21	3517	c.3378G>A	c.(3376-3378)CTG>CTA	p.L1126L	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1126	EGF-like 28.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CTGGTGGGGTCAGGCAGTCAG	0.642													0	0	0	1	0	5	32										T	32170230	C	T	32170230	2	4	65	1	0	0	0	0	0	0	0	1	10551	813	29	1		1	NOTCH4	6	32170230	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	148753	32170230	138944837	500	19533										
HLA-DQA2	3118	broad.mit.edu	37	chr6	32713004	32713004	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctctggccagtacacccatGaatttgatggagacgaggag	12	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:32713004G>A	uc003obx.2	+	2	209	c.151G>A	c.(151-153)GAA>AAA	p.E51K		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	51	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GTACACCCATGAATTTGATGG	0.502													0	0	0	1	0	46	143										A	32713004	G	A	32713004	3	1	65	1	0	0	0	0	1	0	0	0	7205	1291	45	1	157	1	HLA-DQA2	6	32713004	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	542774	32713004	138402063	501	19534										
COL11A2	1302	broad.mit.edu	37	chr6	33135226	33135226	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgagcctgggagccccctcaGaccatcagggccaggtttcc	12	15	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:33135226G>A	uc003ocx.1	-	56	4327	c.4099C>T	c.(4099-4101)CTG>TTG	p.L1367L	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.L1281L|COL11A2_uc003ocz.1_Silent_p.L1260L	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1367	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						AGCCCCCTCAGACCATCAGGG	0.662													0	0	0	1	0	20	53										A	33135226	G	A	33135226	2	1	65	1	0	0	0	0	0	0	0	1	3668	933	33	1		1	COL11A2	6	33135226	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	422222	33135226	137979841	502	19535										
COL11A2	1302	broad.mit.edu	37	chr6	33154506	33154506	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggttttggggtctttccctCtggcccccctcgcattccag	10	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:33154506C>T	uc003ocx.1	-	5	924	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	COL11A2_uc003ocy.1_Silent_p.Q232Q|COL11A2_uc003ocz.1_Silent_p.Q232Q|COL11A2_uc003oda.2_Silent_p.Q232Q	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	232	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GTCTTTCCCTCTGGCCCCCCT	0.562													0	0	0	1	0	36	122										T	33154506	C	T	33154506	2	4	65	1	0	0	0	0	0	0	0	1	3668	912	32	1		1	COL11A2	6	33154506	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	19280	33154506	137960561	503	19536										
RXRB	6257	broad.mit.edu	37	chr6	33165597	33165597	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggcagtactgacagcggttCcgctggcgcttgtccactgt	13	13	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:33165597C>T	uc003odb.2	-	4	941	c.762G>A	c.(760-762)CGG>CGA	p.R254R	RXRB_uc003odc.2_Silent_p.R254R|RXRB_uc003odd.2_Silent_p.R158R|RXRB_uc011dqr.1_Silent_p.R64R|RXRB_uc011dqs.1_Silent_p.R137R|RXRB_uc003ode.1_Silent_p.R118R|RXRB_uc011dqt.1_Silent_p.R254R|RXRB_uc011dqu.1_Silent_p.R158R	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	254	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GACAGCGGTTCCGCTGGCGCT	0.582													0	0	0	1	0	9	48										T	33165597	C	T	33165597	2	4	65	1	0	0	0	0	0	0	0	1	13764	842	30	1		1	RXRB	6	33165597	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11091	33165597	137949470	504	19537										
HSD17B8	7923	broad.mit.edu	37	chr6	33173242	33173242	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggcaccttcctagtcactCaggctgcagcacaagccctg	10	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:33173242C>G	uc003odi.1	+	4	433	c.406C>G	c.(406-408)CAG>GAG	p.Q136E	uc003odj.1_5'Flank|MIR219-1_hsa-mir-219-1|MI0000296_5'Flank	NM_014234	NP_055049	Q92506	DHB8_HUMAN	estradiol 17 beta-dehydrogenase 8	136					estrogen biosynthetic process|fatty acid biosynthetic process	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NAD+) activity			breast(1)|central_nervous_system(1)	2					NADH(DB00157)	CCTAGTCACTCAGGCTGCAGC	0.572													0	0	0	1	0	29	104										G	33173242	C	G	33173242	3	3	65	1	0	0	0	0	1	0	0	0	7389	827	29	1	420	1	HSD17B8	6	33173242	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7645	33173242	137941825	505	19538										
KIF6	221458	broad.mit.edu	37	chr6	39513460	39513460	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaaggatgttattagtttttCcagcctaaaaatacataatg	6	5	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:39513460C>G	uc003oot.2	-	11	1281	c.1186G>C	c.(1186-1188)GAA>CAA	p.E396Q	KIF6_uc010jxa.1_Missense_Mutation_p.E187Q|KIF6_uc011dua.1_Missense_Mutation_p.E396Q|KIF6_uc010jxb.1_Missense_Mutation_p.E396Q	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	396					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						ATTAGTTTTTCCAGCCTAAAA	0.338													0	0	0	1	0	14	41										G	39513460	C	G	39513460	3	3	65	1	0	0	0	0	1	0	0	0	8308	864	30	1	1310	1	KIF6	6	39513460	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6340218	39513460	131601607	506	19539										
PGC	5225	broad.mit.edu	37	chr6	41707611	41707611	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgctggggcacagtgagcaGagaggtgcctgtgtccacga	16	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:41707611G>C	uc003ora.1	-	7	890	c.841C>G	c.(841-843)CTG>GTG	p.L281V		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	281					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			ACAGTGAGCAGAGAGGTGCCT	0.612													0	0	0	1	0	35	87										C	41707611	G	C	41707611	3	2	65	1	0	0	0	0	1	0	0	0	11785	933	33	1	337	1	PGC	6	41707611	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2194151	41707611	129407456	507	19540										
PEX6	5190	broad.mit.edu	37	chr6	42936706	42936706	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagaaggacactgctagttCctgtcagcagggcacccctg	12	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:42936706C>T	uc003otf.2	-	6	1478	c.1385G>A	c.(1384-1386)GGA>GAA	p.G462E	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	462					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			ACTGCTAGTTCCTGTCAGCAG	0.537													0	0	0	1	0	23	73										T	42936706	C	T	42936706	3	4	65	1	0	0	0	0	1	0	0	0	11750	855	30	1	1605	1	PEX6	6	42936706	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1229095	42936706	128178361	508	19541										
C6orf153	88745	broad.mit.edu	37	chr6	42995194	42995194	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcaggcccagcagggccatCggccatacttcctgaaaaaa	9	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:42995194C>T	uc003otp.1	+	6	630	c.622C>T	c.(622-624)CGG>TGG	p.R208W		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	208					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCAGGGCCATCGGCCATACTT	0.572													0	0	0	1	0	29	76										T	42995194	C	T	42995194	3	4	65	1	0	0	0	0	1	0	0	0	2338	875	31	1	644	1	C6orf153	6	42995194	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	58488	42995194	128119873	509	19542										
ABCC10	89845	broad.mit.edu	37	chr6	43415550	43415550	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctggagagaagttgggcatCgtgggccgcacaggctccgg	17	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:43415550C>T	uc003ouy.1	+	18	4049	c.3834C>T	c.(3832-3834)ATC>ATT	p.I1278I	ABCC10_uc003ouz.1_Silent_p.I1250I|ABCC10_uc010jyo.1_Silent_p.I384I	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	1278	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AGTTGGGCATCGTGGGCCGCA	0.642													0	0	0	1	0	70	211										T	43415550	C	T	43415550	2	4	65	1	0	0	0	0	0	0	0	1	50	874	31	1		1	ABCC10	6	43415550	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	420356	43415550	127699517	510	19543										
XPO5	57510	broad.mit.edu	37	chr6	43495465	43495465	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcatctgcagcctcatcttCtccactgcagaaaaccaggg	7	14	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:43495465C>T	uc003ovp.2	-	26	3038	c.2827G>A	c.(2827-2829)GAA>AAA	p.E943K	POLR1C_uc003ovo.1_Intron	NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	943					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GCCTCATCTTCTCCACTGCAG	0.498													0	0	0	1	0	18	50										T	43495465	C	T	43495465	3	4	65	1	0	0	0	0	1	0	0	0	17444	922	32	1	815	1	XPO5	6	43495465	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	79915	43495465	127619602	511	19544										
POLH	5429	broad.mit.edu	37	chr6	43578408	43578408	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgctcacaagatgagccatGatgcatttactgtcatcaag	8	9	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:43578408G>T	uc003ovq.3	+	10	1496	c.1192G>T	c.(1192-1194)GAT>TAT	p.D398Y	POLH_uc010jyu.2_Missense_Mutation_p.D274Y|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.D299Y	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	398					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GATGAGCCATGATGCATTTAC	0.468								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				1	0	2.4624e-09	1	2.56544e-09	19	44										T	43578408	G	T	43578408	3	4	65	1	0	0	0	0	1	0	0	0	12202	1290	45	3	1226	3	POLH	6	43578408	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	82943	43578408	127536659	512	19545										
GTPBP2	54676	broad.mit.edu	37	chr6	43591732	43591732	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgttggtgagtggcggcaGaatattcagaaagactttga	14	5	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:43591732G>T	uc003ovs.2	-	8	1211	c.1174C>A	c.(1174-1176)CTG>ATG	p.L392M	GTPBP2_uc010jyv.2_Missense_Mutation_p.L304M|GTPBP2_uc003ovt.1_Missense_Mutation_p.L392M	NM_019096	NP_061969	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	392							GTP binding|GTPase activity			liver(1)|skin(1)	2	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AGTGGCGGCAGAATATTCAGA	0.512													1	0	2.61193e-14	1	2.75343e-14	31	86										T	43591732	G	T	43591732	3	4	65	1	0	0	0	0	1	0	0	0	6880	933	33	3	654	3	GTPBP2	6	43591732	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13324	43591732	127523335	513	19546										
TMEM63B	55362	broad.mit.edu	37	chr6	44104156	44104156	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctctgtctccagctccgttGactttgaccaaagggacaat	8	13	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:44104156G>C	uc003owr.2	+	5	413	c.349G>C	c.(349-351)GAC>CAC	p.D117H	TMEM63B_uc003owq.1_Missense_Mutation_p.D117H|TMEM63B_uc010jyy.1_Missense_Mutation_p.D20H|TMEM63B_uc003ows.2_Missense_Mutation_p.D20H	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	117						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CAGCTCCGTTGACTTTGACCA	0.577													0	0	0	1	0	18	54										C	44104156	G	C	44104156	3	2	65	1	0	0	0	0	1	0	0	0	16188	1290	45	1	363	1	TMEM63B	6	44104156	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	512424	44104156	127010911	514	19547										
TMEM63B	55362	broad.mit.edu	37	chr6	44107235	44107235	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccgggacaaatgtgggggcGatgccgtgcactacctgtcc	14	12	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:44107235G>A	uc003owr.2	+	7	503	c.439G>A	c.(439-441)GAT>AAT	p.D147N	TMEM63B_uc003owq.1_Missense_Mutation_p.D147N|TMEM63B_uc010jyy.1_Missense_Mutation_p.D50N|TMEM63B_uc003ows.2_Missense_Mutation_p.D50N|TMEM63B_uc010jyz.2_5'Flank	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	147						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			ATGTGGGGGCGATGCCGTGCA	0.582													0	0	0	1	0	21	73										A	44107235	G	A	44107235	3	1	65	1	0	0	0	0	1	0	0	0	16188	1058	37	1	461	1	TMEM63B	6	44107235	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3079	44107235	127007832	515	19548										
TNFRSF21	27242	broad.mit.edu	37	chr6	47254118	47254118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actacagtcatggcatttctCtatgccattctcatgcctgg	7	12	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:47254118C>G	uc003oyv.2	-	2	743	c.310G>C	c.(310-312)GAG>CAG	p.E104Q		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	104	TNFR-Cys 2.|Extracellular (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			TGGCATTTCTCTATGCCATTC	0.522													0	0	0	1	0	46	124										G	47254118	C	G	47254118	3	3	65	1	0	0	0	0	1	0	0	0	16292	922	32	1	1677	1	TNFRSF21	6	47254118	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3146883	47254118	123860949	516	19549										
HMGCLL1	54511	broad.mit.edu	37	chr6	55406893	55406893	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccatccctaggcccaacttCtactattttaacaaactcag	3	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:55406893C>G	uc003pcn.2	-	3	403	c.244G>C	c.(244-246)GAA>CAA	p.E82Q	HMGCLL1_uc003pco.2_Missense_Mutation_p.E52Q|HMGCLL1_uc010jzx.2_5'UTR|HMGCLL1_uc011dxc.1_Missense_Mutation_p.E52Q|HMGCLL1_uc011dxd.1_Missense_Mutation_p.E52Q|HMGCLL1_uc011dxe.1_Missense_Mutation_p.E52Q|HMGCLL1_uc003pcp.2_Missense_Mutation_p.E52Q	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	82							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GGCCCAACTTCTACTATTTTA	0.318													0	0	0	1	0	4	25										G	55406893	C	G	55406893	3	3	65	1	0	0	0	0	1	0	0	0	7230	922	32	1	900	1	HMGCLL1	6	55406893	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8152775	55406893	115708174	517	19550										
DST	667	broad.mit.edu	37	chr6	56507261	56507261	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcttcacagatgacactgtCcctctgaactctgttggcaa	8	12	4	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:56507261C>T	uc003pdf.2	-	15	1748	c.1720G>A	c.(1720-1722)GAC>AAC	p.D574N	DST_uc003pcz.3_Missense_Mutation_p.D396N|DST_uc011dxj.1_Missense_Mutation_p.D425N|DST_uc011dxk.1_Missense_Mutation_p.D436N|DST_uc011dxl.1_Missense_Mutation_p.D425N|DST_uc003pcy.3_Missense_Mutation_p.D70N|DST_uc003pdb.2_Missense_Mutation_p.D70N|DST_uc003pdc.3_Missense_Mutation_p.D70N|DST_uc003pdd.3_Missense_Mutation_p.D70N|DST_uc003pde.2_Missense_Mutation_p.D512N	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	396					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATGACACTGTCCCTCTGAACT	0.403													0	0	0	1	0	11	58										T	56507261	C	T	56507261	3	4	65	1	0	0	0	0	1	0	0	0	4783	855	30	1	20279	1	DST	6	56507261	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1100368	56507261	114607806	518	19551										
PHF3	23469	broad.mit.edu	37	chr6	64389966	64389966	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggcaatgataccattgatGaagaagaactgattttacct	9	6	0	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:64389966G>A	uc003pep.1	+	2	336	c.310G>A	c.(310-312)GAA>AAA	p.E104K	PHF3_uc010kaf.1_Missense_Mutation_p.E104K|PHF3_uc003pem.2_Missense_Mutation_p.E57K|PHF3_uc010kag.1_Missense_Mutation_p.E16K|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Missense_Mutation_p.E16K|PHF3_uc011dxs.1_5'UTR|PHF3_uc003peo.2_Missense_Mutation_p.E104K	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	104					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TACCATTGATGAAGAAGAACT	0.333													0	0	0	1	0	15	74										A	64389966	G	A	64389966	3	1	65	1	0	0	0	0	1	0	0	0	11836	1291	45	1	316	1	PHF3	6	64389966	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7882705	64389966	106725101	519	19552										
PHF3	23469	broad.mit.edu	37	chr6	64389977	64389977	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accattgatgaagaagaactGattttacctaacaggaactt	7	7	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:64389977G>C	uc003pep.1	+	2	347	c.321G>C	c.(319-321)CTG>CTC	p.L107L	PHF3_uc010kaf.1_Silent_p.L107L|PHF3_uc003pem.2_Silent_p.L60L|PHF3_uc010kag.1_Silent_p.L19L|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Silent_p.L19L|PHF3_uc011dxs.1_5'UTR|PHF3_uc003peo.2_Silent_p.L107L	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	107					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAGAAGAACTGATTTTACCTA	0.353													0	0	0	1	0	16	77										C	64389977	G	C	64389977	2	2	65	1	0	0	0	0	0	0	0	1	11836	1277	45	1		1	PHF3	6	64389977	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11	64389977	106725090	520	19553										
BAI3	577	broad.mit.edu	37	chr6	69653779	69653779	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgttcatttacatgtggtcGaggccaaagaacaagaacaa	9	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:69653779G>C	uc003pev.3	+	6	1536	c.1088G>C	c.(1087-1089)CGA>CCA	p.R363P	BAI3_uc010kak.2_Missense_Mutation_p.R363P	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	363	Extracellular (Potential).|TSP type-1 2.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ACATGTGGTCGAGGCCAAAGA	0.438													0	0	0	1	0	22	68										C	69653779	G	C	69653779	3	2	65	1	0	0	0	0	1	0	0	0	1300	1058	37	1	1102	1	BAI3	6	69653779	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5263802	69653779	101461288	521	19554										
LMBRD1	55788	broad.mit.edu	37	chr6	70411792	70411792	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtacttactttgacaagaaGagagaaattacaaacagcaa	7	6	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:70411792G>A	uc003pfa.2	-	10	1084	c.969C>T	c.(967-969)CTC>CTT	p.L323L	LMBRD1_uc003pey.2_Silent_p.L119L|LMBRD1_uc003pez.2_Silent_p.L250L|LMBRD1_uc010kal.2_Silent_p.L250L|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	323	Helical; Name=6; (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						TTGACAAGAAGAGAGAAATTA	0.289													0	0	0	1	0	9	26										A	70411792	G	A	70411792	2	1	65	1	0	0	0	0	0	0	0	1	8842	929	33	1		1	LMBRD1	6	70411792	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	758013	70411792	100703275	522	19555										
COL19A1	1310	broad.mit.edu	37	chr6	70639408	70639408	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaactacatttttagaaatcGagaactccgtcctttgtttg	7	8	0	2	rs151153446	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:70639408G>C	uc003pfc.1	+	6	599	c.482G>C	c.(481-483)CGA>CCA	p.R161P	COL19A1_uc010kam.1_Missense_Mutation_p.R57P	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	161	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TTTAGAAATCGAGAACTCCGT	0.378													0	0	0	1	0	19	65										C	70639408	G	C	70639408	3	2	65	1	0	0	0	0	1	0	0	0	3676	1058	37	1	500	1	COL19A1	6	70639408	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	227616	70639408	100475659	523	19556										
RIMS1	22999	broad.mit.edu	37	chr6	72957812	72957812	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctaaaagatgccccacaagtCttaccagggcaactttctgt	7	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:72957812C>T	uc003pga.2	+	12	2300	c.2223C>T	c.(2221-2223)GTC>GTT	p.V741V	RIMS1_uc011dyb.1_Silent_p.V367V|RIMS1_uc003pgc.2_Silent_p.V367V|RIMS1_uc010kaq.2_Silent_p.V215V|RIMS1_uc011dyc.1_Silent_p.V215V|RIMS1_uc010kar.2_Silent_p.V134V|RIMS1_uc011dyd.1_Silent_p.V200V|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Silent_p.V367V|RIMS1_uc010kas.1_Silent_p.V200V	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	741					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CCCCACAAGTCTTACCAGGGC	0.398													0	0	0	1	0	13	43										T	72957812	C	T	72957812	2	4	65	1	0	0	0	0	0	0	0	1	13367	900	32	1		1	RIMS1	6	72957812	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2318404	72957812	98157255	524	19557										
SLC17A5	26503	broad.mit.edu	37	chr6	74363522	74363522	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accccgccgcttaccggcttCggcccgtggggcgcccggta	14	18	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:74363522C>T	uc003phn.3	-	1	216	c.88G>A	c.(88-90)GAA>AAA	p.E30K	SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_5'UTR	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	30					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						TTACCGGCTTCGGCCCGTGGG	0.726													0	0	0	1	0	4	9										T	74363522	C	T	74363522	3	4	65	1	0	0	0	0	1	0	0	0	14420	893	31	1	1443	1	SLC17A5	6	74363522	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1405710	74363522	96751545	525	19558										
FILIP1	27145	broad.mit.edu	37	chr6	76023801	76023801	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taattcagaggatttttcttCttcacttttcaatttgccta	4	8	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:76023801C>T	uc003pia.2	-	5	2120	c.1747G>A	c.(1747-1749)GAA>AAA	p.E583K	FILIP1_uc003phy.1_Missense_Mutation_p.E583K|FILIP1_uc003phz.2_Missense_Mutation_p.E484K|FILIP1_uc010kbe.2_Missense_Mutation_p.E586K|FILIP1_uc003pib.1_Missense_Mutation_p.E335K	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	583	Potential.									skin(3)|ovary(1)	4						GATTTTTCTTCTTCACTTTTC	0.338													0	0	0	1	0	23	50										T	76023801	C	T	76023801	3	4	65	1	0	0	0	0	1	0	0	0	5894	922	32	1	1902	1	FILIP1	6	76023801	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1660279	76023801	95091266	526	19559										
FILIP1	27145	broad.mit.edu	37	chr6	76063265	76063265	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcacattacctctcccgctCctgctccagcaggttggtga	9	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:76063265C>G	uc003pia.2	-	4	992	c.619G>C	c.(619-621)GAG>CAG	p.E207Q	FILIP1_uc003phy.1_Missense_Mutation_p.E207Q|FILIP1_uc003phz.2_Missense_Mutation_p.E108Q|FILIP1_uc010kbe.2_Missense_Mutation_p.E210Q	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	207	Potential.									skin(3)|ovary(1)	4						CTCTCCCGCTCCTGCTCCAGC	0.527													0	0	0	1	0	42	151										G	76063265	C	G	76063265	3	3	65	1	0	0	0	0	1	0	0	0	5894	864	30	1	3034	1	FILIP1	6	76063265	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	39464	76063265	95051802	527	19560										
FILIP1	27145	broad.mit.edu	37	chr6	76124427	76124427	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctacctgcaactccccttCcattatactgagtagttgga	6	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:76124427C>A	uc003pia.2	-	2	635	c.262G>T	c.(262-264)GAA>TAA	p.E88*	FILIP1_uc003phy.1_Nonsense_Mutation_p.E88*|FILIP1_uc010kbe.2_Nonsense_Mutation_p.E91*	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	88				ELSKEDLIQLLSIMEGE -> AQYAIYIVSRLILLHFL (in Ref. 2; BAA86589).						skin(3)|ovary(1)	4						AACTCCCCTTCCATTATACTG	0.338													1	0	4.10826e-27	1	4.38543e-27	47	145										A	76124427	C	A	76124427	4	1	65	1	0	0	0	0	0	1	0	0	5894	864	30	3	3399	3	FILIP1	6	76124427	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	61162	76124427	94990640	528	19561										
FAM46A	55603	broad.mit.edu	37	chr6	82461733	82461733	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgaagctgccgccaccgccGaagtcgccgccgccgaagtc	12	19	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:82461733G>A	uc003pjg.2	-	2	444	c.126C>T	c.(124-126)TTC>TTT	p.F42F	FAM46A_uc003pjf.2_Silent_p.F61F|FAM46A_uc003pjh.1_Silent_p.F42F	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	42	4.		Missing.								0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		cgccaccgccgaagtcgccgc	0.388													0	0	0	1	0	20	32										A	82461733	G	A	82461733	2	1	65	1	0	0	0	0	0	0	0	1	5565	1049	37	1		1	FAM46A	6	82461733	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6337306	82461733	88653334	529	19562										
TPBG	7162	broad.mit.edu	37	chr6	83075366	83075366	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttacctgccgcgggatgtgCtggcccaactgcccagcctc	11	16	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:83075366C>G	uc003pjn.3	+	3	1624	c.688C>G	c.(688-690)CTG>GTG	p.L230V	TPBG_uc010kbj.2_Missense_Mutation_p.L230V|TPBG_uc003pjo.2_Missense_Mutation_p.L230V	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	230	Extracellular (Potential).|LRR 4.				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		GCGGGATGTGCTGGCCCAACT	0.627													0	0	0	1	0	42	128										G	83075366	C	G	83075366	3	3	65	1	0	0	0	0	1	0	0	0	16391	796	28	4	690	4	TPBG	6	83075366	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	613633	83075366	88039701	530	19563										
PREP	5550	broad.mit.edu	37	chr6	105800901	105800901	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtaccagagtcggtttactgGatcacatccttcccttattg	8	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:105800901G>A	uc003prc.2	-	7	972	c.769C>T	c.(769-771)CCA>TCA	p.P257S		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	257					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	CGGTTTACTGGATCACATCCT	0.378													0	0	0	1	0	35	124										A	105800901	G	A	105800901	3	1	65	1	0	0	0	0	1	0	0	0	12474	1174	41	1	1399	1	PREP	6	105800901	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	22725535	105800901	65314166	531	19564										
MICAL1	64780	broad.mit.edu	37	chr6	109771587	109771587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagaactctctgcccgcatCatgctcgtgaagtcaaaggc	10	13	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:109771587C>G	uc003ptj.2	-	7	1361	c.1107G>C	c.(1105-1107)ATG>ATC	p.M369I	MICAL1_uc003ptk.2_Missense_Mutation_p.M369I|MICAL1_uc010kdr.2_Intron|MICAL1_uc011eaq.1_Missense_Mutation_p.M388I	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	369					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CTGCCCGCATCATGCTCGTGA	0.607													0	0	0	1	0	30	83										G	109771587	C	G	109771587	3	3	65	1	0	0	0	0	1	0	0	0	9569	826	29	1	2168	1	MICAL1	6	109771587	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3970686	109771587	61343480	532	19565										
CDC40	51362	broad.mit.edu	37	chr6	110531931	110531931	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagagcaaaaagaattggatGaaatcacagcaaagaggcag	11	5	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:110531931G>A	uc003pua.2	+	6	676	c.652G>A	c.(652-654)GAA>AAA	p.E218K		NM_015891	NP_056975	O60508	PRP17_HUMAN	cell division cycle 40 homolog	218					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		AGAATTGGATGAAATCACAGC	0.318													0	0	0	1	0	8	10										A	110531931	G	A	110531931	3	1	65	1	0	0	0	0	1	0	0	0	3070	1291	45	1	674	1	CDC40	6	110531931	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	760344	110531931	60583136	533	19566										
CDK19	23097	broad.mit.edu	37	chr6	111136325	111136325	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccgccgccagcttcgccttGaaatcataatccattgtctg	7	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:111136325G>A	uc003puh.1	-	1	88	c.15C>T	c.(13-15)TTC>TTT	p.F5F	AMD1_uc011eay.1_Intron|CDK19_uc003pui.1_Intron|uc003puj.1_5'Flank|CDK19_uc010kdv.1_RNA	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	5							ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GCTTCGCCTTGAAATCATAAT	0.652													0	0	0	1	0	20	49										A	111136325	G	A	111136325	2	1	65	1	0	0	0	0	0	0	0	1	3135	1281	45	1		1	CDK19	6	111136325	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	604394	111136325	59978742	534	19567										
REV3L	5980	broad.mit.edu	37	chr6	111632423	111632423	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgtttaattagacttatatCtctcgtttcaaatagcagct	5	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:111632423C>G	uc003puy.3	-	29	8967	c.8644G>C	c.(8644-8646)GAT>CAT	p.D2882H	REV3L_uc003pux.3_Missense_Mutation_p.D2804H|REV3L_uc003puz.3_Missense_Mutation_p.D2804H|REV3L_uc003pva.1_RNA|REV3L_uc003puw.3_5'Flank	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2882					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGACTTATATCTCTCGTTTCA	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	30	89										G	111632423	C	G	111632423	3	3	65	1	0	0	0	0	1	0	0	0	13240	913	32	1	764	1	REV3L	6	111632423	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	496098	111632423	59482644	535	19568										
RFPL4B	442247	broad.mit.edu	37	chr6	112671523	112671523	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcctgcaagccctcgccttCgccgtgtgggaattttcctg	10	14	0	0	rs143103700	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:112671523C>G	uc003pvx.1	+	3	925	c.613C>G	c.(613-615)CGC>GGC	p.R205G		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	205	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CCCTCGCCTTCGCCGTGTGGG	0.448													0	0	0	1	0	21	50										G	112671523	C	G	112671523	3	3	65	1	0	0	0	0	1	0	0	0	13256	884	31	1	615	1	RFPL4B	6	112671523	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1039100	112671523	58443544	536	19569										
HS3ST5	222537	broad.mit.edu	37	chr6	114379227	114379227	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcatggaggcgaacctgctCcttggaagcgttgcccttcc	12	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:114379227C>G	uc003pwg.3	-	2	267	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.E79Q	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	79	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		CGAACCTGCTCCTTGGAAGCG	0.597													0	0	0	1	0	14	69										G	114379227	C	G	114379227	3	3	65	1	0	0	0	0	1	0	0	0	7368	864	30	1	809	1	HS3ST5	6	114379227	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1707704	114379227	56735840	537	19570										
MAN1A1	4121	broad.mit.edu	37	chr6	119669725	119669725	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtccaccgggggcaggcctCtgaacggcgccttgtcacgc	14	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:119669725C>G	uc003pym.1	-	2	948	c.506G>C	c.(505-507)AGA>ACA	p.R169T	MAN1A1_uc010kei.1_Missense_Mutation_p.R169T	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	169	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		GGGCAGGCCTCTGAACGGCGC	0.632													0	0	0	1	0	28	99										G	119669725	C	G	119669725	3	3	65	1	0	0	0	0	1	0	0	0	9210	913	32	1	1503	1	MAN1A1	6	119669725	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5290498	119669725	51445342	538	19571										
C6orf174	387104	broad.mit.edu	37	chr6	127796494	127796494	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtccgcagacttgggcacctCgaggcggtcgatgaaggtct	15	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:127796494C>G	uc003qbd.2	-	6	3542	c.2677G>C	c.(2677-2679)GAG>CAG	p.E893Q	C6orf174_uc003qbc.2_5'UTR	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	893						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		TTGGGCACCTCGAGGCGGTCG	0.657													0	0	0	1	0	39	124										G	127796494	C	G	127796494	3	3	65	1	0	0	0	0	1	0	0	0	2345	893	31	1	174	1	C6orf174	6	127796494	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8126769	127796494	43318573	539	19572										
LAMA2	3908	broad.mit.edu	37	chr6	129636636	129636636	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcaggtgactctgaaggctGagcagaccattctacccctg	11	12	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:129636636G>A	uc003qbn.2	+	25	3676	c.3571G>A	c.(3571-3573)GAG>AAG	p.E1191K	LAMA2_uc003qbo.2_Missense_Mutation_p.E1191K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1191	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCTGAAGGCTGAGCAGACCAT	0.463													0	0	0	1	0	22	71										A	129636636	G	A	129636636	3	1	65	1	0	0	0	0	1	0	0	0	8606	1291	45	1	3669	1	LAMA2	6	129636636	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1840142	129636636	41478431	540	19573										
SAMD3	154075	broad.mit.edu	37	chr6	130535486	130535486	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttatgaacatactcactctcGagctgcttctgtttgcatga	7	10	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:130535486G>C	uc003qbv.2	-	5	591	c.265C>G	c.(265-267)CGA>GGA	p.R89G	SAMD3_uc003qbx.2_Missense_Mutation_p.R89G|SAMD3_uc003qbw.2_Missense_Mutation_p.R89G|SAMD3_uc010kfg.1_Missense_Mutation_p.R89G|SAMD3_uc003qby.2_Missense_Mutation_p.R89G|SAMD3_uc003qbz.1_Missense_Mutation_p.R48G	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	89										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		ACTCACTCTCGAGCTGCTTCT	0.423													0	0	0	1	0	34	121										C	130535486	G	C	130535486	3	2	65	1	0	0	0	0	1	0	0	0	13820	1066	37	1	1349	1	SAMD3	6	130535486	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	898850	130535486	40579581	541	19574										
SLC2A12	154091	broad.mit.edu	37	chr6	134350213	134350213	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggaggatttgatcacagtGagttcctcagttgtatctga	12	6	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:134350213G>C	uc003qem.1	-	2	921	c.750C>G	c.(748-750)CTC>CTG	p.L250L		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	250	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		TGATCACAGTGAGTTCCTCAG	0.443													0	0	0	1	0	18	67										C	134350213	G	C	134350213	2	2	65	1	0	0	0	0	0	0	0	1	14541	1277	45	1		1	SLC2A12	6	134350213	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3814727	134350213	36764854	542	19575										
MAP7	9053	broad.mit.edu	37	chr6	136683622	136683622	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgctccctcctctccctttCttccttttctctctgctctc	2	20	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:136683622C>G	uc003qgz.2	-	11	1738	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q	MAP7_uc011edf.1_Missense_Mutation_p.E483Q|MAP7_uc011edg.1_Missense_Mutation_p.E528Q|MAP7_uc010kgu.2_Missense_Mutation_p.E520Q|MAP7_uc011edh.1_Missense_Mutation_p.E483Q|MAP7_uc010kgv.2_Missense_Mutation_p.E520Q|MAP7_uc010kgs.2_Missense_Mutation_p.E352Q|MAP7_uc011edi.1_Missense_Mutation_p.E352Q|MAP7_uc010kgq.1_Missense_Mutation_p.E404Q|MAP7_uc003qha.1_Missense_Mutation_p.E461Q	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	498	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CTCTCCCTTTCTTCCTTTTCT	0.527													0	0	0	1	0	47	150										G	136683622	C	G	136683622	3	3	65	1	0	0	0	0	1	0	0	0	9266	922	32	1	789	1	MAP7	6	136683622	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2333409	136683622	34431445	543	19576										
HECA	51696	broad.mit.edu	37	chr6	139487792	139487792	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaagaacacagggaggcctCctggtgaggcggcggaggag	19	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:139487792C>T	uc003qin.2	+	2	928	c.643C>T	c.(643-645)CCT>TCT	p.P215S		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	215					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		AGGGAGGCCTCCTGGTGAGGC	0.597													0	0	0	1	0	14	48										T	139487792	C	T	139487792	3	4	65	1	0	0	0	0	1	0	0	0	7038	855	30	1	649	1	HECA	6	139487792	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2804170	139487792	31627275	544	19577										
SHPRH	257218	broad.mit.edu	37	chr6	146275900	146275900	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgtagccaccccaaatcttCtaacatttcaccactgaagg	5	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:146275900C>G	uc003qlf.2	-	2	958	c.559G>C	c.(559-561)GAA>CAA	p.E187Q	SHPRH_uc003qld.2_Missense_Mutation_p.E187Q|SHPRH_uc003qle.2_Missense_Mutation_p.E187Q|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Missense_Mutation_p.E76Q|SHPRH_uc003qlk.1_Missense_Mutation_p.E187Q	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	187					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CCCAAATCTTCTAACATTTCA	0.363													0	0	0	1	0	15	70										G	146275900	C	G	146275900	3	3	65	1	0	0	0	0	1	0	0	0	14291	922	32	1	4652	1	SHPRH	6	146275900	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6788108	146275900	24839167	545	19578										
SLC22A3	6581	broad.mit.edu	37	chr6	160769463	160769463	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcgcaccatgccctccttCgacgaggcgctgcagcgggt	15	15	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:160769463C>G	uc003qti.2	+	1	39	c.12C>G	c.(10-12)TTC>TTG	p.F4L	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	4						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		TGCCCTCCTTCGACGAGGCGC	0.577													0	0	0	1	0	12	33										G	160769463	C	G	160769463	3	3	65	1	0	0	0	0	1	0	0	0	14455	883	31	1	14	1	SLC22A3	6	160769463	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	14493563	160769463	10345604	546	19579										
LPA	4018	broad.mit.edu	37	chr6	161015047	161015047	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggtgtcatagaggaccaaGactgacatgtccttcctgtg	12	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:161015047G>A	uc003qtl.2	-	23	3692	c.3572C>T	c.(3571-3573)TCT>TTT	p.S1191F		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3699	Kringle 33.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGAGGACCAAGACTGACATGT	0.498													0	0	0	1	0	34	84										A	161015047	G	A	161015047	3	1	65	1	0	0	0	0	1	0	0	0	8903	942	33	1	2622	1	LPA	6	161015047	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	245584	161015047	10100020	547	19580										
TTLL2	83887	broad.mit.edu	37	chr6	167754887	167754887	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggcaggattttcatctgtCaacaagggagatgccacaaa	11	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr6:167754887C>G	uc003qvs.1	+	3	1587	c.1499C>G	c.(1498-1500)TCA>TGA	p.S500*	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	500					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TTTCATCTGTCAACAAGGGAG	0.567													0	0	0	1	0	18	91										G	167754887	C	G	167754887	4	3	65	1	0	0	0	0	0	1	0	0	16724	838	29	1	1509	1	TTLL2	6	167754887	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6739840	167754887	3360180	548	19581										
GET4	51608	broad.mit.edu	37	chr7	926275	926275	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggcggaagtggaggtggctGacgagctgctgggtgagcat	20	6	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:926275G>A	uc003sjl.1	+	3	396	c.304G>A	c.(304-306)GAC>AAC	p.D102N	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	102					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0						GGAGGTGGCTGACGAGCTGCT	0.607													0	0	0	1	0	30	76										A	926275	G	A	926275	3	1	65	1	0	0	0	0	1	0	0	0	6336	1290	45	1	314	1	GET4	7	926275	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		926275	158212388	549	19582										
RBAK	57786	broad.mit.edu	37	chr7	5104113	5104113	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctaagaactcattcaggagaGaaaccctacgaatgtagcga	9	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:5104113G>C	uc010kss.1	+	6	1350	c.1026G>C	c.(1024-1026)GAG>GAC	p.E342D	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.E342D	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	342					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		ATTCAGGAGAGAAACCCTACG	0.443													0	0	0	1	0	40	104										C	5104113	G	C	5104113	3	2	65	1	0	0	0	0	1	0	0	0	13100	933	33	1	1040	1	RBAK	7	5104113	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4177838	5104113	154034550	550	19583										
RBAK	57786	broad.mit.edu	37	chr7	5104735	5104735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatgtggaaagttattcaatGagttgtcatactatactgaa	8	4	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:5104735G>C	uc010kss.1	+	6	1972	c.1648G>C	c.(1648-1650)GAG>CAG	p.E550Q	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.E550Q	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	550	Interaction with AR.|C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GTTATTCAATGAGTTGTCATA	0.388													0	0	0	1	0	15	44										C	5104735	G	C	5104735	3	2	65	1	0	0	0	0	1	0	0	0	13100	1291	45	1	1662	1	RBAK	7	5104735	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	622	5104735	154033928	551	19584										
ACTB	60	broad.mit.edu	37	chr7	5567464	5567464	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgctggaaggtggacagcGaggccaggatggagccgccg	18	10	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:5567464G>C	uc003sos.3	-	5	1079	c.1043C>G	c.(1042-1044)TCG>TGG	p.S348W	ACTB_uc003sor.3_Missense_Mutation_p.S226W|ACTB_uc003sot.3_Missense_Mutation_p.S348W|ACTB_uc003soq.3_Missense_Mutation_p.S226W|ACTB_uc010ksy.2_Missense_Mutation_p.S226W	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	348					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GGTGGACAGCGAGGCCAGGAT	0.587													0	0	0	1	0	34	137										C	5567464	G	C	5567464	3	2	65	1	0	0	0	0	1	0	0	0	193	1059	37	1	88	1	ACTB	7	5567464	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	462729	5567464	153571199	552	19585										
USP42	84132	broad.mit.edu	37	chr7	6193699	6193699	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcccaggacgcaaaggggatGatcgcggagggcccgcggga	18	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:6193699G>A	uc011jwo.1	+	15	2637	c.2514G>A	c.(2512-2514)ATG>ATA	p.M838I	USP42_uc011jwp.1_Missense_Mutation_p.M838I|USP42_uc011jwq.1_Missense_Mutation_p.M645I|USP42_uc011jwr.1_Missense_Mutation_p.M683I	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	838	Pro-rich.				cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		CAAAGGGGATGATCGCGGAGG	0.701													0	0	0	1	0	32	94										A	6193699	G	A	6193699	3	1	65	1	0	0	0	0	1	0	0	0	17070	1290	45	1		1	USP42	7	6193699	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	626235	6193699	152944964	553	19586										
ZNF12	7559	broad.mit.edu	37	chr7	6731839	6731839	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggagaaaggctatttcagatCcattccacttatagggcttt	9	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:6731839C>G	uc003sqt.1	-	5	1288	c.734G>C	c.(733-735)GGA>GCA	p.G245A	ZNF12_uc011jxa.1_Missense_Mutation_p.G83A|ZNF12_uc003sqs.1_Missense_Mutation_p.G207A	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	245					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TATTTCAGATCCATTCCACTT	0.393													0	0	0	1	0	11	32										G	6731839	C	G	6731839	3	3	65	1	0	0	0	0	1	0	0	0	17715	855	30	1	1363	1	ZNF12	7	6731839	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	538140	6731839	152406824	554	19587										
ZNF12	7559	broad.mit.edu	37	chr7	6731904	6731904	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgtccttttggaaggctttCtggcattcaatatattcaaa	8	7	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:6731904C>G	uc003sqt.1	-	5	1223	c.669G>C	c.(667-669)CAG>CAC	p.Q223H	ZNF12_uc011jxa.1_Missense_Mutation_p.Q61H|ZNF12_uc003sqs.1_Missense_Mutation_p.Q185H	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	223					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GGAAGGCTTTCTGGCATTCAA	0.348													0	0	0	1	0	3	26										G	6731904	C	G	6731904	3	3	65	1	0	0	0	0	1	0	0	0	17715	912	32	1	1428	1	ZNF12	7	6731904	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	65	6731904	152406759	555	19588										
SNX13	23161	broad.mit.edu	37	chr7	17931249	17931249	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctggcttcccgtttcatttCttctaagcacttaaaggaaa	6	11	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:17931249C>T	uc003stw.1	-	4	451	c.238G>A	c.(238-240)GAA>AAA	p.E80K	SNX13_uc003stv.2_Missense_Mutation_p.E80K|SNX13_uc010kuc.2_5'UTR|SNX13_uc003stx.1_5'UTR|SNX13_uc003sty.2_Missense_Mutation_p.E80K			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	80					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					CGTTTCATTTCTTCTAAGCAC	0.368													0	0	0	1	0	5	21										T	17931249	C	T	17931249	3	4	65	1	0	0	0	0	1	0	0	0	14884	922	32	1	2727	1	SNX13	7	17931249	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11199345	17931249	141207414	556	19589										
DNAH11	8701	broad.mit.edu	37	chr7	21640356	21640356	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagatcatgaacagagtggtGaatgtcatcaacaaagtctt	10	6	4	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:21640356G>A	uc003svc.2	+	16	3094	c.3063G>A	c.(3061-3063)GTG>GTA	p.V1021V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1021	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ACAGAGTGGTGAATGTCATCA	0.428									Kartagener_syndrome				0	0	0	1	0	47	145										A	21640356	G	A	21640356	2	1	65	1	0	0	0	0	0	0	0	1	4599	1277	45	1		1	DNAH11	7	21640356	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3709107	21640356	137498307	557	19590										
DNAH11	8701	broad.mit.edu	37	chr7	21856220	21856220	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgctatcctaacacactgtGagcgctggcctctggtgata	10	13	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:21856220G>A	uc003svc.2	+	65	10520	c.10489G>A	c.(10489-10491)GAG>AAG	p.E3497K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3497	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AACACACTGTGAGCGCTGGCC	0.488									Kartagener_syndrome				0	0	0	1	0	9	27										A	21856220	G	A	21856220	3	1	65	1	0	0	0	0	1	0	0	0	4599	1291	45	1	10744	1	DNAH11	7	21856220	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	215864	21856220	137282443	558	19591										
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26236541	26236541	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcaatttttccatattcctCaaagtaatctctaaggtgat	4	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:26236541C>G	uc003sxr.3	-	5	613	c.397G>C	c.(397-399)GAG>CAG	p.E133Q	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.E121Q	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	133	RRM 2.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCATATTCCTCAAAGTAATCT	0.383			T	ETV1	prostate								0	0	0	1	0	43	90										G	26236541	C	G	26236541	3	3	65	1	0	0	0	0	1	0	0	0	7259	835	29	1	692	1	HNRNPA2B1	7	26236541	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4380321	26236541	132902122	559	19592										
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26240221	26240221	+	Translation_Start_Site	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggactcagtcgcttcagcccGatttcccgcagccgagcgag	12	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:26240221G>C	uc003sxr.3	-	1	193	c.-23C>G	c.(-25--21)ATCGG>ATGGG		HNRNPA2B1_uc003sxs.3_Translation_Start_Site|CBX3_uc003sxt.2_5'Flank|CBX3_uc003sxu.2_5'Flank|CBX3_uc003sxv.2_5'Flank	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1						RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GCTTCAGCCCGATTTCCCGCA	0.577			T	ETV1	prostate								0	0	0	1	0	48	166										C	26240221	G	C	26240221	1	2	65	1	0	0	0	0	0	0	0	0	7259	1073	37	1		1	HNRNPA2B1	7	26240221	Translation_Start_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3680	26240221	132898442	560	19593										
CHN2	1124	broad.mit.edu	37	chr7	29440222	29440222	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaacactttgtgggtgagaaGaggtttgagtcgattcatga	13	4	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:29440222G>C	uc003szz.2	+	6	791	c.354G>C	c.(352-354)AAG>AAC	p.K118N	CHN2_uc011jzs.1_Missense_Mutation_p.K193N|CHN2_uc010kva.2_Intron|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.K83N|CHN2_uc011jzt.1_Missense_Mutation_p.K131N|CHN2_uc010kvd.2_Intron|CHN2_uc011jzu.1_Missense_Mutation_p.K103N	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	118	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						TGGGTGAGAAGAGGTTTGAGT	0.448													0	0	0	1	0	24	65										C	29440222	G	C	29440222	3	2	65	1	0	0	0	0	1	0	0	0	3363	933	33	1	376	1	CHN2	7	29440222	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3200001	29440222	129698441	561	19594										
GHRHR	2692	broad.mit.edu	37	chr7	31013635	31013635	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgtggccgcctcccatttCgccaccatgaccaacttcag	7	17	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:31013635C>T	uc003tbx.2	+	7	681	c.633C>T	c.(631-633)TTC>TTT	p.F211F	GHRHR_uc003tbw.1_Silent_p.F211F|GHRHR_uc003tby.2_Silent_p.F147F|GHRHR_uc003tbz.2_Intron	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	211	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CCTCCCATTTCGCCACCATGA	0.627													0	0	0	1	0	40	85										T	31013635	C	T	31013635	2	4	65	1	0	0	0	0	0	0	0	1	6373	883	31	1		1	GHRHR	7	31013635	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1573413	31013635	128125028	562	19595										
ADCYAP1R1	117	broad.mit.edu	37	chr7	31126105	31126105	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actctgctggtggagaccttCttccctgaaaggagatactt	10	10	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:31126105C>T	uc003tca.1	+	10	1000	c.777C>T	c.(775-777)TTC>TTT	p.F259F	ADCYAP1R1_uc003tcb.1_Silent_p.F238F|ADCYAP1R1_uc003tcc.1_Silent_p.F259F|ADCYAP1R1_uc003tcd.1_Silent_p.F259F|ADCYAP1R1_uc003tce.1_Silent_p.F259F|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	259	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TGGAGACCTTCTTCCCTGAAA	0.532													0	0	0	1	0	9	48										T	31126105	C	T	31126105	2	4	65	1	0	0	0	0	0	0	0	1	303	912	32	1		1	ADCYAP1R1	7	31126105	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	112470	31126105	128012558	563	19596										
KBTBD2	25948	broad.mit.edu	37	chr7	32914744	32914744	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacatgggtttgtttgctttCacttagtccactcataaaca	6	9	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:32914744C>T	uc003tdb.2	-	3	855	c.196G>A	c.(196-198)GAA>AAA	p.E66K	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	66	BTB.										0			GBM - Glioblastoma multiforme(11;0.0499)			TGTTTGCTTTCACTTAGTCCA	0.393													0	0	0	1	0	35	142										T	32914744	C	T	32914744	3	4	65	1	0	0	0	0	1	0	0	0	7993	835	29	1	1683	1	KBTBD2	7	32914744	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1788639	32914744	126223919	564	19597										
ELMO1	9844	broad.mit.edu	37	chr7	37298857	37298857	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ataaactcctgggcaaacgtGacatcccgggagaggctggc	13	11	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:37298857G>A	uc003tfk.1	-	6	649	c.342C>T	c.(340-342)GTC>GTT	p.V114V	ELMO1_uc011kbc.1_Silent_p.V18V|ELMO1_uc010kxg.1_Silent_p.V114V	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	114					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GGGCAAACGTGACATCCCGGG	0.547													0	0	0	1	0	11	40										A	37298857	G	A	37298857	2	1	65	1	0	0	0	0	0	0	0	1	5065	1277	45	1		1	ELMO1	7	37298857	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4384113	37298857	121839806	565	19598										
CAMK2B	816	broad.mit.edu	37	chr7	44364973	44364973	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacttgccaatatcctcgtaGagctggtactcgtcggtgaa	10	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:44364973G>C	uc003tkq.2	-	1	258	c.48C>G	c.(46-48)CTC>CTG	p.L16L	CAMK2B_uc003tkp.2_Silent_p.L16L|CAMK2B_uc003tkx.2_Silent_p.L16L|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Silent_p.L16L|CAMK2B_uc003tks.2_Silent_p.L16L|CAMK2B_uc003tku.2_Silent_p.L16L|CAMK2B_uc003tkv.2_Silent_p.L16L|CAMK2B_uc003tkt.2_Silent_p.L16L|CAMK2B_uc003tkw.2_Silent_p.L16L|CAMK2B_uc010kyc.2_Silent_p.L16L	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	16	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						TATCCTCGTAGAGCTGGTACT	0.756													0	0	0	1	0	6	10										C	44364973	G	C	44364973	2	2	65	1	0	0	0	0	0	0	0	1	2600	929	33	1		1	CAMK2B	7	44364973	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7066116	44364973	114773690	566	19599										
NPC1L1	29881	broad.mit.edu	37	chr7	44576463	44576463	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgtaccccccaatggcaagGaaggggaagacaggggcccc	14	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:44576463G>T	uc003tlb.2	-	3	1715	c.1659C>A	c.(1657-1659)TTC>TTA	p.F553L	NPC1L1_uc003tlc.2_Missense_Mutation_p.F553L|NPC1L1_uc011kbw.1_Missense_Mutation_p.F553L|NPC1L1_uc003tld.2_Missense_Mutation_p.F553L	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	553	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	CAATGGCAAGGAAGGGGAAGA	0.597													1	0	1.9806e-07	1	2.0496e-07	23	62										T	44576463	G	T	44576463	3	4	65	1	0	0	0	0	1	0	0	0	10571	1165	41	3	2492	3	NPC1L1	7	44576463	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	211490	44576463	114562200	567	19600										
ABCA13	154664	broad.mit.edu	37	chr7	48273724	48273724	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttcacacggaacagatcctGaactcttcagctgaactgaa	7	12	3	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:48273724G>A	uc003toq.2	+	8	898	c.873G>A	c.(871-873)CTG>CTA	p.L291L	ABCA13_uc010kyr.2_5'UTR	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	291					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AACAGATCCTGAACTCTTCAG	0.502													0	0	0	1	0	26	78										A	48273724	G	A	48273724	2	1	65	1	0	0	0	0	0	0	0	1	31	1277	45	1		1	ABCA13	7	48273724	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3697261	48273724	110864939	568	19601										
EGFR	1956	broad.mit.edu	37	chr7	55270282	55270282	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accccacaggcgccttgactGaggacagcatagacgacacc	10	15	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:55270282G>A	uc003tqk.2	+	27	3481	c.3235G>A	c.(3235-3237)GAG>AAG	p.E1079K	EGFR_uc010kzg.1_Missense_Mutation_p.E1034K|EGFR_uc011kco.1_Missense_Mutation_p.E1026K	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	1079	Cytoplasmic (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCCTTGACTGAGGACAGCAT	0.567		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			0	0	0	1	0	8	18										A	55270282	G	A	55270282	3	1	65	1	0	0	0	0	1	0	0	0	4967	1291	45	1	3605	1	EGFR	7	55270282	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6996558	55270282	103868381	569	19602										
ZNF107	51427	broad.mit.edu	37	chr7	64168318	64168318	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtactatacataaaattattCatactggagagaaaccctac	5	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:64168318C>T	uc003ttd.2	+	7	2422	c.1636C>T	c.(1636-1638)CAT>TAT	p.H546Y	ZNF107_uc003tte.2_Missense_Mutation_p.H546Y	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	546	C2H2-type 17; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TAAAATTATTCATACTGGAGA	0.348													0	0	0	1	0	11	35										T	64168318	C	T	64168318	3	4	65	1	0	0	0	0	1	0	0	0	17712	826	29	1	1642	1	ZNF107	7	64168318	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8898036	64168318	94970345	570	19603										
SBDS	51119	broad.mit.edu	37	chr7	66453431	66453431	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagaacctttgcctttagttTccttttttattagctcatca	4	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:66453431T>C	uc003tvm.1	-	5	864	c.680A>G	c.(679-681)GAA>GGA	p.E227G		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	227					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						GCCTTTAGTTTCCTTTTTTAT	0.388			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				0	0	0	1	0	16	48										C	66453431	T	C	66453431	3	2	65	1	0	0	0	0	1	0	0	0	13857	1783	62	5	76	5	SBDS	7	66453431	Missense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	2285113	66453431	92685232	571	19604										
CACNA2D1	781	broad.mit.edu	37	chr7	81600022	81600022	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aactctggtaatcccaccatCagtcacaacaaatcgtgctt	5	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:81600022C>G	uc003uhr.1	-	27	2429	c.2173G>C	c.(2173-2175)GAT>CAT	p.D725H	CACNA2D1_uc011kgy.1_5'UTR	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	737	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATCCCACCATCAGTCACAACA	0.353													0	0	0	1	0	12	73										G	81600022	C	G	81600022	3	3	65	1	0	0	0	0	1	0	0	0	2548	826	29	1	1154	1	CACNA2D1	7	81600022	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	15146591	81600022	77538641	572	19605										
STEAP1	26872	broad.mit.edu	37	chr7	89790200	89790200	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcccatgctgatgaatttGactgcccttcagaacttcag	8	12	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:89790200G>C	uc003ujx.2	+	3	366	c.166G>C	c.(166-168)GAC>CAC	p.D56H	STEAP1_uc010lem.2_Missense_Mutation_p.D56H	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	56					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					TGATGAATTTGACTGCCCTTC	0.423													0	0	0	1	0	40	155										C	89790200	G	C	89790200	3	2	65	1	0	0	0	0	1	0	0	0	15276	1290	45	1	172	1	STEAP1	7	89790200	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8190178	89790200	69348463	573	19606										
SAMD9	54809	broad.mit.edu	37	chr7	92732279	92732279	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaccaatttcctgtttcaccTtcatgttcatcgcggtgtct	6	12	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:92732279T>A	uc003umf.2	-	3	3388	c.3132A>T	c.(3130-3132)GAA>GAT	p.E1044D	SAMD9_uc003umg.2_Missense_Mutation_p.E1044D	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1044						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CTGTTTCACCTTCATGTTCAT	0.378													0	0	0	1	0	19	35										A	92732279	T	A	92732279	3	1	65	1	0	0	0	0	1	0	0	0	13826	1606	56	5	1641	5	SAMD9	7	92732279	Missense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	2942079	92732279	66406384	574	19607										
TFPI2	7980	broad.mit.edu	37	chr7	93516176	93516176	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccggattctactggcaaagcGaagctttggcatcttctttt	9	10	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:93516176G>A	uc003umy.1	-	5	739	c.664C>T	c.(664-666)CGC>TGC	p.R222C	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_3'UTR|TFPI2_uc003una.1_Missense_Mutation_p.R211C|TFPI2_uc003unb.1_Missense_Mutation_p.R228C|TFPI2_uc010lfg.1_Missense_Mutation_p.R98C	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	222					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			CTGGCAAAGCGAAGCTTTGGC	0.328													0	0	0	1	0	11	52										A	93516176	G	A	93516176	3	1	65	1	0	0	0	0	1	0	0	0	15806	1058	37	1	47	1	TFPI2	7	93516176	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	783897	93516176	65622487	575	19608										
PEG10	23089	broad.mit.edu	37	chr7	94293511	94293511	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggcctcagcgaccacattCaggaggagctctcccacctc	10	16	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:94293511C>T	uc011kie.1	+	2	1088	c.871C>T	c.(871-873)CAG>TAG	p.Q291*		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	215	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CGACCACATTCAGGAGGAGCT	0.582													0	0	0	1	0	38	131										T	94293511	C	T	94293511	4	4	65	1	0	0	0	0	0	1	0	0	11719	839	29	1	877	1	PEG10	7	94293511	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	777335	94293511	64845152	576	19609										
PON1	5444	broad.mit.edu	37	chr7	94935662	94935662	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatcttatgagccagcaactCagctatatagacataccttc	5	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:94935662C>G	uc003uns.2	-	7	812	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	PON1_uc011kih.1_Missense_Mutation_p.E239Q	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	239					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GCCAGCAACTCAGCTATATAG	0.353													0	0	0	1	0	20	64										G	94935662	C	G	94935662	3	3	65	1	0	0	0	0	1	0	0	0	12248	835	29	1	364	1	PON1	7	94935662	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	642151	94935662	64203001	577	19610										
TRRAP	8295	broad.mit.edu	37	chr7	98533223	98533223	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgttgaatttgtgtgaggctGaagattcagctttaacaaag	11	4	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:98533223G>A	uc003upp.2	+	28	4245	c.4036G>A	c.(4036-4038)GAA>AAA	p.E1346K	TRRAP_uc011kis.1_Missense_Mutation_p.E1346K|TRRAP_uc003upr.2_Missense_Mutation_p.E1038K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1346					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GTGTGAGGCTGAAGATTCAGC	0.388													0	0	0	1	0	7	30										A	98533223	G	A	98533223	3	1	65	1	0	0	0	0	1	0	0	0	16598	1291	45	1	4142	1	TRRAP	7	98533223	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3597561	98533223	60605440	578	19611										
PDAP1	11333	broad.mit.edu	37	chr7	99002548	99002548	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagggcttgtatactgcctCgcccggcctttgtggcctcc	11	15	1	0	rs139029496		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:99002548C>T	uc003uqe.2	-	2	163	c.42G>A	c.(40-42)GCG>GCA	p.A14A		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	14					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	TATACTGCCTCGCCCGGCCTT	0.632													0	0	0	1	0	15	62										T	99002548	C	T	99002548	2	4	65	1	0	0	0	0	0	0	0	1	11613	871	31	1		1	PDAP1	7	99002548	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	469325	99002548	60136115	579	19612										
BUD31	8896	broad.mit.edu	37	chr7	99013816	99013816	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaatctctgtggcccatcttCaggatccaccaccagaaaac	7	14	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:99013816C>G	uc003uqf.2	+	4	351	c.150C>G	c.(148-150)TTC>TTG	p.F50L	BUD31_uc011kiu.1_Missense_Mutation_p.F50L|BUD31_uc011kiv.1_Missense_Mutation_p.F50L|BUD31_uc003uqg.3_Missense_Mutation_p.F50L	NM_003910	NP_003901	P41223	BUD31_HUMAN	G10 protein	50					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GGCCCATCTTCAGGATCCACC	0.493													0	0	0	1	0	30	79										G	99013816	C	G	99013816	3	3	65	1	0	0	0	0	1	0	0	0	1574	825	29	1	156	1	BUD31	7	99013816	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11268	99013816	60124847	580	19613										
CPSF4	10898	broad.mit.edu	37	chr7	99050001	99050001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtgaccagccctcgatttGaactgcccatgggaaccacc	10	14	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:99050001G>C	uc003uqj.2	+	6	651	c.508G>C	c.(508-510)GAA>CAA	p.E170Q	PTCD1_uc011kiw.1_Intron|CPSF4_uc003uqi.2_Missense_Mutation_p.E170Q|CPSF4_uc003uqk.2_Missense_Mutation_p.E170Q|CPSF4_uc011kix.1_Missense_Mutation_p.E117Q	NM_006693	NP_006684	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4,	170					modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CCCTCGATTTGAACTGCCCAT	0.592													0	0	0	1	0	71	243										C	99050001	G	C	99050001	3	2	65	1	0	0	0	0	1	0	0	0	3828	1291	45	1	530	1	CPSF4	7	99050001	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	36185	99050001	60088662	581	19614										
CYP3A43	64816	broad.mit.edu	37	chr7	99453289	99453289	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaaagatgttacccatttttTaaaaaattccattgaaagga	5	5	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:99453289T>A	uc003urx.1	+	8	849	c.746T>A	c.(745-747)TTA>TAA	p.L249*	CYP3A43_uc003ury.1_Nonsense_Mutation_p.L249*|CYP3A43_uc003urz.1_Nonsense_Mutation_p.L249*|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Nonsense_Mutation_p.L139*|CYP3A43_uc003usb.1_Intron	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	249			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	ACCCATTTTTTAAAAAATTCC	0.244													0	0	0	1	0	7	17										A	99453289	T	A	99453289	4	1	65	1	0	0	0	0	0	1	0	0	4179	1764	61	5	776	5	CYP3A43	7	99453289	Nonsense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	403288	99453289	59685374	582	19615										
PILRB	29990	broad.mit.edu	37	chr7	99957061	99957061	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagaatcatggcacctaagtCtggacactgccatcagggtt	10	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:99957061C>T	uc003uuk.2	+	17	3052	c.556C>T	c.(556-558)CTG>TTG	p.L186L	PILRB_uc003uul.2_Missense_Mutation_p.S116F|PILRB_uc003uun.2_Silent_p.L186L	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	186	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCACCTAAGTCTGGACACTGC	0.562													0	0	0	1	0	22	76										T	99957061	C	T	99957061	2	4	65	1	0	0	0	0	0	0	0	1	11926	913	32	1		1	PILRB	7	99957061	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	503772	99957061	59181602	583	19616										
C7orf51	222950	broad.mit.edu	37	chr7	100084635	100084635	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acgctccctctcctgccactCggtgggcagcatggacagtg	12	15	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:100084635C>T	uc003uvd.1	+	3	419	c.260C>T	c.(259-261)TCG>TTG	p.S87L	C7orf51_uc003uve.1_5'Flank	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	87										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCCTGCCACTCGGTGGGCAGC	0.711													0	0	0	1	0	7	34										T	100084635	C	T	100084635	3	4	65	1	0	0	0	0	1	0	0	0	2400	893	31	1	266	1	C7orf51	7	100084635	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	127574	100084635	59054028	584	19617										
C7orf51	222950	broad.mit.edu	37	chr7	100086600	100086600	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagggctctggccagccccGgggggagcgggagctcccca	17	16	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:100086600G>A	uc003uvd.1	+	4	1415	c.1256G>A	c.(1255-1257)CGG>CAG	p.R419Q	C7orf51_uc003uve.1_Missense_Mutation_p.R201Q	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	419	Pro-rich.									skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCCAGCCCCGGGGGGAGCGG	0.577													0	0	0	1	0	6	31										A	100086600	G	A	100086600	3	1	65	1	0	0	0	0	1	0	0	0	2400	1116	39	2	1266	2	C7orf51	7	100086600	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1965	100086600	59052063	585	19618										
ACTL6B	51412	broad.mit.edu	37	chr7	100245112	100245112	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttggagacctggggtagcttCtccttcttcttccagtttgg	11	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:100245112C>T	uc003uvy.2	-	8	821	c.714G>A	c.(712-714)GAG>GAA	p.E238E	ACTL6B_uc003uvx.1_Silent_p.E29E|ACTL6B_uc003uvz.2_RNA	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	238					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGGGTAGCTTCTCCTTCTTCT	0.612													0	0	0	1	0	27	99										T	100245112	C	T	100245112	2	4	65	1	0	0	0	0	0	0	0	1	199	912	32	1		1	ACTL6B	7	100245112	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	158512	100245112	58893551	586	19619										
EPO	2056	broad.mit.edu	37	chr7	100320678	100320678	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgacactttccgcaaactCttccgagtctactccaattt	5	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:100320678C>G	uc003uwi.2	+	5	685	c.504C>G	c.(502-504)CTC>CTG	p.L168L	EPO_uc011kkc.1_Silent_p.L167L	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	168					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	TCCGCAAACTCTTCCGAGTCT	0.567													0	0	0	1	0	57	169										G	100320678	C	G	100320678	2	3	65	1	0	0	0	0	0	0	0	1	5188	900	32	1		1	EPO	7	100320678	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	75566	100320678	58817985	587	19620										
PLOD3	8985	broad.mit.edu	37	chr7	100856159	100856159	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcctccggtcctggttgcaGaagccacagcctccctcagg	11	16	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:100856159G>A	uc003uyd.2	-	8	1299	c.843C>T	c.(841-843)TTC>TTT	p.F281F	PLOD3_uc010lhs.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	281					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CCTGGTTGCAGAAGCCACAGC	0.647													0	0	0	1	0	19	43										A	100856159	G	A	100856159	2	1	65	1	0	0	0	0	0	0	0	1	12103	933	33	1		1	PLOD3	7	100856159	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	535481	100856159	58282504	588	19621										
FBXL13	222235	broad.mit.edu	37	chr7	102462632	102462632	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcattttgccgataacatctCcattgctgagtcagtaatct	7	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:102462632C>G	uc003vaq.2	-	19	2300	c.1873G>C	c.(1873-1875)GAG>CAG	p.E625Q	FBXL13_uc010liq.1_Missense_Mutation_p.E158Q|FBXL13_uc010lir.1_Missense_Mutation_p.E580Q|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.E597Q|FAM185A_uc011klh.1_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	625	LRR 16.										0						GATAACATCTCCATTGCTGAG	0.373													0	0	0	1	0	19	56										G	102462632	C	G	102462632	3	3	65	1	0	0	0	0	1	0	0	0	5709	864	30	1	342	1	FBXL13	7	102462632	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1606473	102462632	56676031	589	19622										
SLC26A5	375611	broad.mit.edu	37	chr7	103017300	103017300	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tataccgacgtctccatattCttttacaatctgtaataatg	4	9	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:103017300C>G	uc003vbz.2	-	19	2232	c.1996G>C	c.(1996-1998)GAA>CAA	p.E666Q	SLC26A5_uc003vbt.1_Missense_Mutation_p.E666Q|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Missense_Mutation_p.E634Q|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	666	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						TCTCCATATTCTTTTACAATC	0.328													0	0	0	1	0	5	34										G	103017300	C	G	103017300	3	3	65	1	0	0	0	0	1	0	0	0	14520	922	32	1	287	1	SLC26A5	7	103017300	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	554668	103017300	56121363	590	19623										
DOCK4	9732	broad.mit.edu	37	chr7	111541796	111541796	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccacatttctggccacgctCttccctcctttctcaaattc	3	17	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:111541796C>T	uc003vfx.2	-	14	1523	c.1254G>A	c.(1252-1254)AAG>AAA	p.K418K	DOCK4_uc003vfy.2_Silent_p.K418K|DOCK4_uc003vga.1_Silent_p.K23K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	418	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TGGCCACGCTCTTCCCTCCTT	0.358													0	0	0	1	0	7	24										T	111541796	C	T	111541796	2	4	65	1	0	0	0	0	0	0	0	1	4689	912	32	1		1	DOCK4	7	111541796	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8524496	111541796	47596867	591	19624										
MDFIC	29969	broad.mit.edu	37	chr7	114655760	114655760	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agattgttgtgtccactgtaTcctggcttgcttgttctgcg	11	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:114655760T>C	uc003vhf.2	+	5	1102	c.839T>C	c.(838-840)ATC>ACC	p.I280T		NM_199072	NP_951038	Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing protein	171	Cys-rich.				activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleolus|nucleolus|nucleus	cyclin binding|Tat protein binding			ovary(1)	1						GTCCACTGTATCCTGGCTTGC	0.443													0	0	0	1	0	92	317										C	114655760	T	C	114655760	3	2	65	1	0	0	0	0	1	0	0	0	9405	1435	50	5	899	5	MDFIC	7	114655760	Missense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	3113964	114655760	44482903	592	19625										
CTTNBP2	83992	broad.mit.edu	37	chr7	117431347	117431347	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcaggccaggcacccacctGagacgtggccagggctgaaa	14	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:117431347G>A	uc003vjf.2	-	4	1995	c.1903C>T	c.(1903-1905)CAG>TAG	p.Q635*		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	635										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GCACCCACCTGAGACGTGGCC	0.552													0	0	0	1	0	15	55										A	117431347	G	A	117431347	4	1	65	1	0	0	0	0	0	1	0	0	4045	1299	45	1	3168	1	CTTNBP2	7	117431347	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2775587	117431347	41707316	593	19626										
C7orf58	79974	broad.mit.edu	37	chr7	120764493	120764493	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagcggctgaagtattcagtGaaacatctactctgggacca	10	9	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:120764493G>A	uc003vjq.3	+	8	1474	c.1027G>A	c.(1027-1029)GAA>AAA	p.E343K	C7orf58_uc003vjr.1_Missense_Mutation_p.E343K|C7orf58_uc003vjs.3_Missense_Mutation_p.E343K|C7orf58_uc003vjt.3_Missense_Mutation_p.E123K|C7orf58_uc010lkk.1_Missense_Mutation_p.E123K	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	343						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AGTATTCAGTGAAACATCTAC	0.338													0	0	0	1	0	7	35										A	120764493	G	A	120764493	3	1	65	1	0	0	0	0	1	0	0	0	2405	1291	45	1	1053	1	C7orf58	7	120764493	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3333146	120764493	38374170	594	19627										
AASS	10157	broad.mit.edu	37	chr7	121738811	121738811	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttatttacctactgttatttCtatattgccatctcttgata	3	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:121738811C>G	uc003vka.2	-	13	1612	c.1516G>C	c.(1516-1518)GAA>CAA	p.E506Q	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.E506Q|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	506	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACTGTTATTTCTATATTGCCA	0.333													0	0	0	1	0	14	33										G	121738811	C	G	121738811	3	3	65	1	0	0	0	0	1	0	0	0	24	922	32	1	1308	1	AASS	7	121738811	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	974318	121738811	37399852	595	19628										
CPA2	1358	broad.mit.edu	37	chr7	129916530	129916530	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggatgccctggatatcttCctcctgccagtcacaaaccc	7	16	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:129916530C>T	uc003vpq.2	+	7	667	c.648C>T	c.(646-648)TTC>TTT	p.F216F	CPA2_uc011kpc.1_Silent_p.F216F	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	216					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TGGATATCTTCCTCCTGCCAG	0.453													0	0	0	1	0	24	89										T	129916530	C	T	129916530	2	4	65	1	0	0	0	0	0	0	0	1	3790	854	30	1		1	CPA2	7	129916530	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8177719	129916530	29222133	596	19629										
CPA1	1357	broad.mit.edu	37	chr7	130027841	130027841	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcatggagcacaccctgaatCacccctactgagctgaccct	7	16	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:130027841C>T	uc003vpx.2	+	10	1321	c.1249C>T	c.(1249-1251)CAC>TAC	p.H417Y		NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	417					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					CACCCTGAATCACCCCTACTG	0.567													0	0	0	1	0	66	233										T	130027841	C	T	130027841	3	4	65	1	0	0	0	0	1	0	0	0	3789	826	29	1	1287	1	CPA1	7	130027841	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	111311	130027841	29110822	597	19630										
TMEM140	55281	broad.mit.edu	37	chr7	134849404	134849404	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcaccagttccctgagctgGaagccctgggggtgcctcgg	15	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:134849404G>A	uc003vsi.2	+	2	492	c.211G>A	c.(211-213)GAA>AAA	p.E71K	C7orf49_uc003vsh.2_Intron	NM_018295	NP_060765	Q9NV12	TM140_HUMAN	transmembrane protein 140	71	Extracellular (Potential).					integral to membrane				large_intestine(1)	1						CCCTGAGCTGGAAGCCCTGGG	0.622													0	0	0	1	0	48	115										A	134849404	G	A	134849404	3	1	65	1	0	0	0	0	1	0	0	0	16052	1175	41	1	213	1	TMEM140	7	134849404	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4821563	134849404	24289259	598	19631										
MGAM	8972	broad.mit.edu	37	chr7	141721466	141721466	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaaatgctgctgcttctttGacctaccaagttgaaatctc	8	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:141721466G>C	uc003vwy.2	+	6	693	c.639G>C	c.(637-639)TTG>TTC	p.L213F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	213	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTGCTTCTTTGACCTACCAAG	0.428													0	0	0	1	0	16	64										C	141721466	G	C	141721466	3	2	65	1	0	0	0	0	1	0	0	0	9541	1281	45	1	657	1	MGAM	7	141721466	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6872062	141721466	17417197	599	19632										
EPHB6	2051	broad.mit.edu	37	chr7	142566063	142566063	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtcaggccatccgagaactTgcccgggaagtcgatcctgc	12	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:142566063T>C	uc011kst.1	+	14	2770	c.1983T>C	c.(1981-1983)CTT>CTC	p.L661L	EPHB6_uc011ksu.1_Silent_p.L661L|EPHB6_uc003wbs.2_Silent_p.L369L|EPHB6_uc003wbt.2_Silent_p.L135L|EPHB6_uc003wbu.2_Silent_p.L369L|EPHB6_uc003wbv.2_Silent_p.L45L	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	661	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					TCCGAGAACTTGCCCGGGAAG	0.567													0	0	0	1	0	20	79										C	142566063	T	C	142566063	2	2	65	1	0	0	0	0	0	0	0	1	5178	1799	63	5		5	EPHB6	7	142566063	Silent	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	844597	142566063	16572600	600	19633										
TRPV5	56302	broad.mit.edu	37	chr7	142612712	142612712	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agctcccccaccagcctgatGatatcttcacgtgtctcata	6	15	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:142612712G>A	uc003wby.1	-	9	1413	c.1149C>T	c.(1147-1149)ATC>ATT	p.I383I		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	383	Extracellular (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CCAGCCTGATGATATCTTCAC	0.527													0	0	0	1	0	16	50										A	142612712	G	A	142612712	2	1	65	1	0	0	0	0	0	0	0	1	16596	1280	45	1		1	TRPV5	7	142612712	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	46649	142612712	16525951	601	19634										
CUL1	8454	broad.mit.edu	37	chr7	148457547	148457547	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttataccagagagagtactGaattcttgcagcagaaccca	8	9	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:148457547G>T	uc010lpg.2	+	7	1274	c.748G>T	c.(748-750)GAA>TAA	p.E250*	CUL1_uc003wey.2_Nonsense_Mutation_p.E250*|CUL1_uc003wez.2_Nonsense_Mutation_p.E140*	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	250					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AGAGAGTACTGAATTCTTGCA	0.348													1	0	3.7052e-28	1	3.95767e-28	42	99										T	148457547	G	T	148457547	4	4	65	1	0	0	0	0	0	1	0	0	4054	1291	45	3	770	3	CUL1	7	148457547	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5844835	148457547	10681116	602	19635										
EZH2	2146	broad.mit.edu	37	chr7	148512132	148512132	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacatggttagaggagccgtCtgagtaaagataacatcatg	11	6	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:148512132C>G	uc003wfd.1	-	14	1698	c.1532_splice	c.e14-1	p.D511_splice	EZH2_uc011kug.1_Intron|EZH2_uc003wfb.1_Splice_Site_p.D516_splice|EZH2_uc003wfc.1_Splice_Site_p.D472_splice|EZH2_uc011kuh.1_Splice_Site_p.D502_splice	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a						negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			GAGGAGCCGTCTGAGTAAAGA	0.443			Mis		DLBCL								0	0	0	1	0	8	25										G	148512132	C	G	148512132	5	3	65	1	0	0	0	0	0	0	1	0	5334	927	32	1	737	1	EZH2	7	148512132	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	54585	148512132	10626531	603	19636										
EZH2	2146	broad.mit.edu	37	chr7	148514356	148514356	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attaacctagcaatggcacaGaaattgtcatagtaagtgcc	8	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:148514356G>A	uc003wfd.1	-	11	1519	c.1353C>T	c.(1351-1353)TTC>TTT	p.F451F	EZH2_uc011kug.1_Silent_p.F442F|EZH2_uc003wfb.1_Silent_p.F456F|EZH2_uc003wfc.1_Silent_p.F412F|EZH2_uc011kuh.1_Silent_p.F442F|EZH2_uc011kui.1_3'UTR	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	451					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			CAATGGCACAGAAATTGTCAT	0.378			Mis		DLBCL								0	0	0	1	0	7	23										A	148514356	G	A	148514356	2	1	65	1	0	0	0	0	0	0	0	1	5334	933	33	1		1	EZH2	7	148514356	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2224	148514356	10624307	604	19637										
SSPO	23145	broad.mit.edu	37	chr7	149503891	149503891	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaggggggtccttgccctCggctatgcctgacgcagggc	17	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:149503891C>G	uc010lpk.2	+	60	8719	c.8719C>G	c.(8719-8721)CGG>GGG	p.R2907G		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2907					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCCTTGCCCTCGGCTATGCCT	0.612													0	0	0	1	0	4	12										G	149503891	C	G	149503891	3	3	65	1	0	0	0	0	1	0	0	0	15188	875	31	1	8949	1	SSPO	7	149503891	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	989535	149503891	9634772	605	19638										
ABCB8	11194	broad.mit.edu	37	chr7	150738289	150738289	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acccttgacccctcctggctCcggggccaggttgtcggctt	12	16	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:150738289C>A	uc003wil.3	+	14	1731	c.1638C>A	c.(1636-1638)CTC>CTA	p.L546L	ABCB8_uc010lpw.1_3'UTR|ABCB8_uc010lpx.2_Silent_p.L529L|ABCB8_uc011kvd.1_Silent_p.L441L|ABCB8_uc003wim.3_Silent_p.L324L|ABCB8_uc003wik.3_Silent_p.L529L	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	546	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCTGGCTCCGGGGCCAGG	0.697													1	0	4.3838e-07	1	4.52823e-07	13	71										A	150738289	C	A	150738289	2	1	65	1	0	0	0	0	0	0	0	1	47	842	30	3		3	ABCB8	7	150738289	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1234398	150738289	8400374	606	19639										
AGAP3	116988	broad.mit.edu	37	chr7	150835257	150835257	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccactcggccagcagcgcatCcctgcactctgagcgccccc	9	21	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:150835257C>T	uc003wjg.1	+	12	1526	c.1523C>T	c.(1522-1524)TCC>TTC	p.S508F	AGAP3_uc003wje.1_Intron|AGAP3_uc003wjj.1_Intron|AGAP3_uc003wjk.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	472	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						AGCAGCGCATCCCTGCACTCT	0.682													0	0	0	1	0	7	27										T	150835257	C	T	150835257	3	4	65	1	0	0	0	0	1	0	0	0	369	855	30	1	1636	1	AGAP3	7	150835257	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	96968	150835257	8303406	607	19640										
GALNT11	63917	broad.mit.edu	37	chr7	151802337	151802337	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actttattttcagatgatttGaaaggagaactagatgaata	8	3	1	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:151802337G>A	uc010lqg.1	+	5	824	c.594G>A	c.(592-594)TTG>TTA	p.L198L	GALNT11_uc011kvm.1_Silent_p.L117L|GALNT11_uc003wku.2_Silent_p.L198L|GALNT11_uc011kvn.1_RNA|GALNT11_uc003wkw.1_5'Flank	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	198	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CAGATGATTTGAAAGGAGAAC	0.328													0	0	0	1	0	10	44										A	151802337	G	A	151802337	2	1	65	1	0	0	0	0	0	0	0	1	6209	1281	45	1		1	GALNT11	7	151802337	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	967080	151802337	7336326	608	19641										
MLL3	58508	broad.mit.edu	37	chr7	151859702	151859702	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgactcttggtcggcttgttGaggaagctcactgggtgtgc	15	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:151859702G>A	uc003wla.2	-	43	11179	c.10960C>T	c.(10960-10962)CAA>TAA	p.Q3654*	MLL3_uc003wkz.2_Nonsense_Mutation_p.Q2715*|MLL3_uc003wky.2_Nonsense_Mutation_p.Q1163*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3654					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCGGCTTGTTGAGGAAGCTCA	0.532			N		medulloblastoma								0	0	0	1	0	35	100										A	151859702	G	A	151859702	4	1	65	1	0	0	0	0	0	1	0	0	9622	1299	45	1	3843	1	MLL3	7	151859702	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	57365	151859702	7278961	609	19642										
NCAPG2	54892	broad.mit.edu	37	chr7	158456891	158456891	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcacagtcacattctccttCtcccttccgtcctcttcctc	2	20	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:158456891C>T	uc003wnv.1	-	15	1945	c.1800G>A	c.(1798-1800)GAG>GAA	p.E600E	NCAPG2_uc010lqu.1_Silent_p.E392E|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.E600E|NCAPG2_uc011kwe.1_Silent_p.E600E|NCAPG2_uc011kwc.1_Silent_p.E101E|NCAPG2_uc011kwd.1_Silent_p.E101E	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	600					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CATTCTCCTTCTCCCTTCCGT	0.512													0	0	0	1	0	11	82										T	158456891	C	T	158456891	2	4	65	1	0	0	0	0	0	0	0	1	10208	912	32	1		1	NCAPG2	7	158456891	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6597189	158456891	681772	610	19643										
WDR60	55112	broad.mit.edu	37	chr7	158723187	158723187	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaagctggtacatagtgctCtgatccagttgggtgacagg	13	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr7:158723187C>T	uc003woe.3	+	21	2685	c.2527C>T	c.(2527-2529)CTG>TTG	p.L843L	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Silent_p.L475L	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	843										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		ACATAGTGCTCTGATCCAGTT	0.408													0	0	0	1	0	4	16										T	158723187	C	T	158723187	2	4	65	1	0	0	0	0	0	0	0	1	17308	912	32	1		1	WDR60	7	158723187	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	266296	158723187	415476	611	19644										
CSMD1	64478	broad.mit.edu	37	chr8	4851876	4851876	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcgctgcagtgaggagcctCgcgcacagcaccagcagccc	12	16	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:4851876C>T	uc011kwk.1	-	1	453	c.63G>A	c.(61-63)GCG>GCA	p.A21A		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	21						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGAGGAGCCTCGCGCACAGCA	0.647													0	0	0	1	0	7	46										T	4851876	C	T	4851876	2	4	65	1	0	0	0	0	0	0	0	1	3944	871	31	1		1	CSMD1	8	4851876	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		4851876	141512146	612	19645										
SGK223	157285	broad.mit.edu	37	chr8	8175697	8175697	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacagaagctgcaggagcttCagcgactgtaagagggcccc	13	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:8175697C>T	uc003wsh.3	-	5	4188	c.4188G>A	c.(4186-4188)CTG>CTA	p.L1396L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1396							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GCAGGAGCTTCAGCGACTGTA	0.657													0	0	0	1	0	26	57										T	8175697	C	T	8175697	2	4	65	1	0	0	0	0	0	0	0	1	14210	813	29	1		1	SGK223	8	8175697	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3323821	8175697	138188325	613	19646										
SGK223	157285	broad.mit.edu	37	chr8	8176545	8176545	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacgcgccgctcgtacgcctCgggctccgcctggtggctgg	15	17	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:8176545C>T	uc003wsh.3	-	5	3340	c.3340G>A	c.(3340-3342)GAG>AAG	p.E1114K		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1114	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCGTACGCCTCGGGCTCCGCC	0.672													0	0	0	1	0	78	203										T	8176545	C	T	8176545	3	4	65	1	0	0	0	0	1	0	0	0	14210	893	31	1	872	1	SGK223	8	8176545	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	848	8176545	138187477	614	19647										
MFHAS1	9258	broad.mit.edu	37	chr8	8750290	8750290	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgaagcggttcctgcgcagGaccaggacgcgcaggctgcc	16	14	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:8750290G>C	uc003wsj.1	-	1	842	c.279C>G	c.(277-279)GTC>GTG	p.V93V		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	93	LRR 2.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TCCTGCGCAGGACCAGGACGC	0.721													0	0	0	1	0	5	14										C	8750290	G	C	8750290	2	2	65	1	0	0	0	0	0	0	0	1	9521	1161	41	1		1	MFHAS1	8	8750290	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	573745	8750290	137613732	615	19648										
TNFRSF10A	8797	broad.mit.edu	37	chr8	23049437	23049437	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agctctgaccacatcgatctCatttttcgtgaggtccagct	8	12	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:23049437C>T	uc003xda.2	-	10	1242	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K		NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	393	Cytoplasmic (Potential).|Death.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		ACATCGATCTCATTTTTCGTG	0.522													0	0	0	1	0	47	51										T	23049437	C	T	23049437	3	4	65	1	0	0	0	0	1	0	0	0	16277	835	29	1	233	1	TNFRSF10A	8	23049437	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	14299147	23049437	123314585	616	19649										
TNFRSF10A	8797	broad.mit.edu	37	chr8	23049482	23049482	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catgagctggtcccaggagtCaaagggcacgatgtttgcaa	13	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:23049482C>T	uc003xda.2	-	10	1197	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N		NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	378	Cytoplasmic (Potential).|Death.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TCCCAGGAGTCAAAGGGCACG	0.527													0	0	0	1	0	19	60										T	23049482	C	T	23049482	3	4	65	1	0	0	0	0	1	0	0	0	16277	826	29	1	278	1	TNFRSF10A	8	23049482	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	45	23049482	123314540	617	19650										
NEFM	4741	broad.mit.edu	37	chr8	24775109	24775109	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagctgaaggagaggaagccGaagctaaagaggaaaagaaa	14	4	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:24775109G>A	uc003xed.3	+	3	1774	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K	NEFM_uc011lac.1_Missense_Mutation_p.E581K|NEFM_uc010lue.2_Missense_Mutation_p.E205K	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	581	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		agaggaagccgaagctaaaga	0.259													0	0	0	1	0	5	23										A	24775109	G	A	24775109	3	1	65	1	0	0	0	0	1	0	0	0	10316	1059	37	1	1751	1	NEFM	8	24775109	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1725627	24775109	121588913	618	19651										
NEFL	4747	broad.mit.edu	37	chr8	24811727	24811727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atctcaatatccaaagccatCttcacgttgaggaggtcttg	8	10	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:24811727C>G	uc003xee.2	-	2	1239	c.1137G>C	c.(1135-1137)AAG>AAC	p.K379N		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	379	Rod.|Coil 2B.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CCAAAGCCATCTTCACGTTGA	0.393													0	0	0	1	0	36	139										G	24811727	C	G	24811727	3	3	65	1	0	0	0	0	1	0	0	0	10315	912	32	1	507	1	NEFL	8	24811727	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	36618	24811727	121552295	619	19652										
SCARA5	286133	broad.mit.edu	37	chr8	27729502	27729502	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcggcatgtccacagtttgtCaccccccatttggagaagct	9	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:27729502C>T	uc003xgj.2	-	9	1877	c.1437G>A	c.(1435-1437)GTG>GTA	p.V479V	SCARA5_uc010luz.2_Silent_p.V254V	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	479	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CACAGTTTGTCACCCCCCATT	0.577													0	0	0	1	0	23	78										T	27729502	C	T	27729502	2	4	65	1	0	0	0	0	0	0	0	1	13880	813	29	1		1	SCARA5	8	27729502	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2917775	27729502	118634520	620	19653										
INTS9	55756	broad.mit.edu	37	chr8	28671062	28671062	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actaagggcagagttcacctCttgcattgtatagcatcttc	8	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:28671062C>G	uc003xha.2	-	7	855	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	INTS9_uc011lav.1_Missense_Mutation_p.E162Q|INTS9_uc011law.1_Missense_Mutation_p.E165Q|INTS9_uc011lax.1_Missense_Mutation_p.E79Q|INTS9_uc010lvc.2_RNA|INTS9_uc003xhb.2_Missense_Mutation_p.E186Q	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	186					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		GAGTTCACCTCTTGCATTGTA	0.413													0	0	0	1	0	34	101										G	28671062	C	G	28671062	3	3	65	1	0	0	0	0	1	0	0	0	7785	922	32	1	1464	1	INTS9	8	28671062	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	941560	28671062	117692960	621	19654										
GSR	2936	broad.mit.edu	37	chr8	30560623	30560623	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gactcaccggggatctggctCtcatgaggggtggagggcat	17	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:30560623C>T	uc003xih.1	-	5	718	c.627G>A	c.(625-627)GAG>GAA	p.E209E		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	209					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	GGATCTGGCTCTCATGAGGGG	0.527													0	0	0	1	0	37	113										T	30560623	C	T	30560623	2	4	65	1	0	0	0	0	0	0	0	1	6828	912	32	1		1	GSR	8	30560623	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1889561	30560623	115803399	622	19655										
PURG	29942	broad.mit.edu	37	chr8	30889344	30889344	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaaattttcctcatctcttCttcatacttgataaaattct	2	10	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:30889344C>T	uc003xin.2	-	1	974	c.955G>A	c.(955-957)GAA>AAA	p.E319K	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Intron	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	319						nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		CTCATCTCTTCTTCATACTTG	0.403													0	0	0	1	0	4	3										T	30889344	C	T	30889344	3	4	65	1	0	0	0	0	1	0	0	0	12829	922	32	1	201	1	PURG	8	30889344	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	328721	30889344	115474678	623	19656										
WRN	7486	broad.mit.edu	37	chr8	30969307	30969307	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatctgcagccatttcttgtCaaaacaaggtaaggatttaa	8	7	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:30969307C>G	uc003xio.3	+	19	3053	c.2265C>G	c.(2263-2265)GTC>GTG	p.V755V	WRN_uc010lvk.2_Silent_p.V222V	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	755	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CATTTCTTGTCAAAACAAGGT	0.328			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	1	0	13	31										G	30969307	C	G	30969307	2	3	65	1	0	0	0	0	0	0	0	1	17399	813	29	1		1	WRN	8	30969307	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	79963	30969307	115394715	624	19657										
WRN	7486	broad.mit.edu	37	chr8	31024573	31024573	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctaatcagaatgttagttCctgaaaacattgacacgtac	7	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:31024573C>T	uc003xio.3	+	34	4806	c.4018C>T	c.(4018-4020)CCT>TCT	p.P1340S	WRN_uc010lvk.2_Missense_Mutation_p.P807S	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1340					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AATGTTAGTTCCTGAAAACAT	0.343			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	1	0	18	35										T	31024573	C	T	31024573	3	4	65	1	0	0	0	0	1	0	0	0	17399	855	30	1	4148	1	WRN	8	31024573	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	55266	31024573	115339449	625	19658										
FUT10	84750	broad.mit.edu	37	chr8	33310999	33310999	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggaacttttaaactccttCctttcaaacttccccagctc	3	15	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:33310999C>T	uc003xje.2	-	3	467	c.111G>A	c.(109-111)AGG>AGA	p.R37R	FUT10_uc003xjc.2_Silent_p.R44R|FUT10_uc003xjd.2_Silent_p.R9R|FUT10_uc011lbi.1_Silent_p.R87R|FUT10_uc003xjf.2_5'UTR|FUT10_uc003xjg.2_Silent_p.R9R|FUT10_uc003xjh.2_Silent_p.R37R|FUT10_uc003xji.1_Silent_p.R37R	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	37	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TAAACTCCTTCCTTTCAAACT	0.363													0	0	0	1	0	19	70										T	33310999	C	T	33310999	2	4	65	1	0	0	0	0	0	0	0	1	6102	854	30	1		1	FUT10	8	33310999	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2286426	33310999	113053023	626	19659										
KCNU1	157855	broad.mit.edu	37	chr8	36698504	36698504	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccatcgaatacaagtccctCtttacggatggtttctggta	9	10	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:36698504C>G	uc010lvw.2	+	16	1773	c.1686C>G	c.(1684-1686)CTC>CTG	p.L562L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	562	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACAAGTCCCTCTTTACGGATG	0.403													0	0	0	1	0	15	39										G	36698504	C	G	36698504	2	3	65	1	0	0	0	0	0	0	0	1	8093	900	32	1		1	KCNU1	8	36698504	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3387505	36698504	109665518	627	19660										
FGFR1	2260	broad.mit.edu	37	chr8	38282030	38282030	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actggtgccatgattaccttCaagatctggacataaggcag	10	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:38282030C>G	uc003xlp.2	-	7	1875	c.933G>C	c.(931-933)TTG>TTC	p.L311F	FGFR1_uc011lbo.1_Missense_Mutation_p.L309F|FGFR1_uc011lbp.1_Missense_Mutation_p.L222F|FGFR1_uc011lbq.1_Missense_Mutation_p.L220F|FGFR1_uc010lwk.2_Missense_Mutation_p.L303F|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.L151F|FGFR1_uc011lbt.1_Missense_Mutation_p.L220F|FGFR1_uc011lbu.1_Missense_Mutation_p.L342F|FGFR1_uc011lbv.1_Missense_Mutation_p.L309F|FGFR1_uc011lbw.1_Missense_Mutation_p.L222F|FGFR1_uc011lbx.1_Missense_Mutation_p.L222F|FGFR1_uc003xlv.2_Missense_Mutation_p.L222F|FGFR1_uc003xlu.2_Missense_Mutation_p.L220F	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	311	Ig-like C2-type 3.|Extracellular (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	TGATTACCTTCAAGATCTGGA	0.567		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						0	0	0	1	0	34	73										G	38282030	C	G	38282030	3	3	65	1	0	0	0	0	1	0	0	0	5863	825	29	1	1823	1	FGFR1	8	38282030	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1583526	38282030	108081992	628	19661										
ADAM18	8749	broad.mit.edu	37	chr8	39495221	39495221	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgacatagcatacttacttGtgtaagcacaatgttctaca	6	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:39495221G>C	uc003xni.2	+	9	826	c.826G>C	c.(826-828)GTT>CTT	p.V276L	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.V252L	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	276	Peptidase M12B.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATACTTACTTGTGTAAGCACA	0.353													0	0	0	1	0	10	18										C	39495221	G	C	39495221	3	2	65	1	0	0	0	0	1	0	0	0	239	1391	48	4	860	4	ADAM18	8	39495221	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1213191	39495221	106868801	629	19662										
POTEA	340441	broad.mit.edu	37	chr8	43147757	43147757	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagcggcaagaacaacatgGgtgcttggagagaccacgac	14	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:43147757G>A	uc003xpz.1	+	1	173	c.130G>A	c.(130-132)GGT>AGT	p.G44S	POTEA_uc003xqa.1_Missense_Mutation_p.G44S	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	44										ovary(1)	1						GAACAACATGGGTGCTTGGAG	0.602													0	0	0	1	0	41	113										A	43147757	G	A	43147757	3	1	65	1	0	0	0	0	1	0	0	0	12261	1232	43	2	132	2	POTEA	8	43147757	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3652536	43147757	103216265	630	19663										
KIAA0146	23514	broad.mit.edu	37	chr8	48309060	48309060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagtttgcatcggatgcaaGacagattatggagagactga	13	6	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:48309060G>C	uc003xqd.2	+	6	659	c.650G>C	c.(649-651)AGA>ACA	p.R217T	KIAA0146_uc011lcz.1_Intron|KIAA0146_uc011lda.1_Intron|KIAA0146_uc011ldb.1_Missense_Mutation_p.R217T|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.R147T|KIAA0146_uc011ldd.1_Missense_Mutation_p.R157T|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	217											0		Lung NSC(58;0.175)				TCGGATGCAAGACAGATTATG	0.408													0	0	0	1	0	33	87										C	48309060	G	C	48309060	3	2	65	1	0	0	0	0	1	0	0	0	8157	942	33	1	672	1	KIAA0146	8	48309060	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5161303	48309060	98054962	631	19664										
KIAA0146	23514	broad.mit.edu	37	chr8	48641546	48641546	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggtcacatctcctgttctCaagaggcacctgcaggtctt	10	12	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:48641546C>G	uc003xqd.2	+	18	2496	c.2487C>G	c.(2485-2487)CTC>CTG	p.L829L	KIAA0146_uc011ldc.1_Silent_p.L759L|KIAA0146_uc011ldd.1_Silent_p.L769L|KIAA0146_uc003xqe.2_Silent_p.L304L|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc010lxt.2_Intron|KIAA0146_uc011ldf.1_Silent_p.L334L|KIAA0146_uc011ldg.1_Silent_p.L319L|KIAA0146_uc003xqg.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	829											0		Lung NSC(58;0.175)				CTCCTGTTCTCAAGAGGCACC	0.592													0	0	0	1	0	15	78										G	48641546	C	G	48641546	2	3	65	1	0	0	0	0	0	0	0	1	8157	813	29	1		1	KIAA0146	8	48641546	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	332486	48641546	97722476	632	19665										
PCMTD1	115294	broad.mit.edu	37	chr8	52733177	52733177	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttttgggtggagccctttGaggaatccccttggcctgca	12	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:52733177G>A	uc003xqx.3	-	6	1149	c.808C>T	c.(808-810)CAA>TAA	p.Q270*	PCMTD1_uc011ldm.1_Nonsense_Mutation_p.Q140*|PCMTD1_uc003xqw.3_Nonsense_Mutation_p.Q270*|PCMTD1_uc011ldn.1_Nonsense_Mutation_p.Q82*|PCMTD1_uc010lya.2_Nonsense_Mutation_p.Q194*	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	270						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				GGAGCCCTTTGAGGAATCCCC	0.423													0	0	0	1	0	9	143										A	52733177	G	A	52733177	4	1	65	1	0	0	0	0	0	1	0	0	11586	1299	45	1	269	1	PCMTD1	8	52733177	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4091631	52733177	93630845	633	19666										
RB1CC1	9821	broad.mit.edu	37	chr8	53558413	53558413	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgaagaatctcctctggtaGagtcaatggcaggacttaca	10	8	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:53558413G>A	uc003xre.3	-	16	4394	c.3836C>T	c.(3835-3837)TCT>TTT	p.S1279F	RB1CC1_uc003xrf.3_Missense_Mutation_p.S1279F	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	1279	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TCCTCTGGTAGAGTCAATGGC	0.308													0	0	0	1	0	16	39										A	53558413	G	A	53558413	3	1	65	1	0	0	0	0	1	0	0	0	13099	942	33	1	984	1	RB1CC1	8	53558413	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	825236	53558413	92805609	634	19667										
RP1	6101	broad.mit.edu	37	chr8	55537354	55537354	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagtacttggccttagaaaaGaatgattctcagaatttacc	7	7	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:55537354G>C	uc003xsd.1	+	4	1060	c.912G>C	c.(910-912)AAG>AAC	p.K304N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	304					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCTTAGAAAAGAATGATTCTC	0.318													0	0	0	1	0	4	35										C	55537354	G	C	55537354	3	2	65	1	0	0	0	0	1	0	0	0	13532	933	33	1	922	1	RP1	8	55537354	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1978941	55537354	90826668	635	19668										
RP1	6101	broad.mit.edu	37	chr8	55538471	55538471	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaaaaagaagaaaaaatctCgacagcaagcaataaattcc	6	8	1	2	rs104894082		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:55538471C>T	uc003xsd.1	+	4	2177	c.2029C>T	c.(2029-2031)CGA>TGA	p.R677*	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	677					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GAAAAAATCTCGACAGCAAGC	0.323													0	0	0	1	0	9	25										T	55538471	C	T	55538471	4	4	65	1	0	0	0	0	0	1	0	0	13532	876	31	1	2039	1	RP1	8	55538471	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1117	55538471	90825551	636	19669										
CHD7	55636	broad.mit.edu	37	chr8	61693580	61693580	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attccccgtcggagccctttCtagagaaaccagtgccggat	10	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:61693580C>T	uc003xue.2	+	3	2164	c.1687C>T	c.(1687-1689)CTA>TTA	p.L563L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	563	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGAGCCCTTTCTAGAGAAACC	0.433													0	0	0	1	0	5	16										T	61693580	C	T	61693580	2	4	65	1	0	0	0	0	0	0	0	1	3330	912	32	1		1	CHD7	8	61693580	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6155109	61693580	84670442	637	19670										
CHD7	55636	broad.mit.edu	37	chr8	61773577	61773577	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggatccctgttatcaatcttGaagatgggactaggctggtg	13	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:61773577G>C	uc003xue.2	+	35	8200	c.7723G>C	c.(7723-7725)GAA>CAA	p.E2575Q		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2575					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TATCAATCTTGAAGATGGGAC	0.458													0	0	0	1	0	16	47										C	61773577	G	C	61773577	3	2	65	1	0	0	0	0	1	0	0	0	3330	1291	45	1	7857	1	CHD7	8	61773577	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	79997	61773577	84590445	638	19671										
VCPIP1	80124	broad.mit.edu	37	chr8	67576660	67576660	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttagaatttctattgtaattCtgtcgccatgctgtaaagga	8	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:67576660C>T	uc003xwn.2	-	1	2793	c.2534G>A	c.(2533-2535)AGA>AAA	p.R845K		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	845					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TATTGTAATTCTGTCGCCATG	0.428													0	0	0	1	0	20	61										T	67576660	C	T	67576660	3	4	65	1	0	0	0	0	1	0	0	0	17138	913	32	1	1146	1	VCPIP1	8	67576660	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5803083	67576660	78787362	639	19672										
ARFGEF1	10565	broad.mit.edu	37	chr8	68150658	68150658	+	Frame_Shift_Del	DEL	G	G	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgcctcgcactgttccaGaaatgtatcgaggtttcact							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:68150658delG	uc003xxo.1	-	22	3599	c.3209delC	c.(3208-3210)TCTfs	p.S1070fs	ARFGEF1_uc003xxl.1_Frame_Shift_Del_p.S524fs|ARFGEF1_uc003xxn.1_Frame_Shift_Del_p.S53fs	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1070					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CACTGTTCCAGAAATGTATCG	0.398																		15	49	---	---								-	68150658	G	-	68150658	7	5	65	1	0	1	0	1	0	0	0	0	852	942	33	0	2412	0	ARFGEF1	8	68150658	Frame_Shift_Del	DEL	G	TCGA-DK-A3WW-01A-22D-A23M-08	573998	68150658	78213364	640	19673										
PREX2	80243	broad.mit.edu	37	chr8	69039652	69039652	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctggctcttcttgaatattCaggtaacattttgcatttta	6	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:69039652C>T	uc003xxv.1	+	31	3791	c.3764C>T	c.(3763-3765)TCA>TTA	p.S1255L		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1255					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CTTGAATATTCAGGTAACATT	0.353													0	0	0	1	0	15	55										T	69039652	C	T	69039652	3	4	65	1	0	0	0	0	1	0	0	0	12477	838	29	1	4115	1	PREX2	8	69039652	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	888994	69039652	77324370	641	19674										
KCNB2	9312	broad.mit.edu	37	chr8	73848659	73848659	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagcctggtattttttgctGagaaggatgaagatgctacc	11	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:73848659G>A	uc003xzb.2	+	3	1657	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	357					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ATTTTTTGCTGAGAAGGATGA	0.448													0	0	0	1	0	42	128										A	73848659	G	A	73848659	3	1	65	1	0	0	0	0	1	0	0	0	8013	1291	45	1	1075	1	KCNB2	8	73848659	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4809007	73848659	72515363	642	19675										
ZFHX4	79776	broad.mit.edu	37	chr8	77775830	77775830	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcccacctgtctgtggcatgGagagcctctttccttatggc	10	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:77775830G>A	uc003yav.2	+	11	10132	c.9745G>A	c.(9745-9747)GAG>AAG	p.E3249K		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTGTGGCATGGAGAGCCTCTT	0.443										HNSCC(33;0.089)			0	0	0	1	0	17	51										A	77775830	G	A	77775830	3	1	65	1	0	0	0	0	1	0	0	0	17632	1175	41	1	9918	1	ZFHX4	8	77775830	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3927171	77775830	68588192	643	19676										
SNX16	64089	broad.mit.edu	37	chr8	82714735	82714735	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggttctaaagacaatgttCtaaaagtatgttatagcaac	7	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:82714735C>G	uc011lft.1	-	8	1326	c.819_splice	c.e8-1	p.R273_splice	SNX16_uc003ycn.2_Splice_Site_p.R273_splice|SNX16_uc003yco.2_Splice_Site_p.R244_splice	NM_022133	NP_071416	P57768	SNX16_HUMAN	sorting nexin 16 isoform a						cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			ovary(1)|pancreas(1)	2						AGACAATGTTCTAAAAGTATG	0.368													0	0	0	1	0	5	21										G	82714735	C	G	82714735	5	3	65	1	0	0	0	0	0	0	1	0	14887	927	32	1	224	1	SNX16	8	82714735	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4938905	82714735	63649287	644	19677										
RUNX1T1	862	broad.mit.edu	37	chr8	92972658	92972658	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgatggtgcttctcccagtCtttgtgctggcaaaatgagc	12	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:92972658C>G	uc003yfd.2	-	11	1711	c.1627G>C	c.(1627-1629)GAC>CAC	p.D543H	RUNX1T1_uc003yfc.1_Missense_Mutation_p.D516H|RUNX1T1_uc003yfe.1_Missense_Mutation_p.D506H|RUNX1T1_uc010mao.2_Missense_Mutation_p.D516H|RUNX1T1_uc011lgi.1_Missense_Mutation_p.D554H|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Missense_Mutation_p.D168H|RUNX1T1_uc003yfb.1_Missense_Mutation_p.D506H	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	543	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCTCCCAGTCTTTGTGCTGG	0.567													0	0	0	1	0	19	42										G	92972658	C	G	92972658	3	3	65	1	0	0	0	0	1	0	0	0	13747	913	32	1	191	1	RUNX1T1	8	92972658	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	10257923	92972658	53391364	645	19678										
TMEM67	91147	broad.mit.edu	37	chr8	94808168	94808168	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttgctgccaatgccaattCaggaagaacgttttgtcact	8	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:94808168C>G	uc011lgk.1	+	18	1884	c.1813C>G	c.(1813-1815)CAG>GAG	p.Q605E	TMEM67_uc010maw.2_Missense_Mutation_p.Q311E|TMEM67_uc003yga.3_Missense_Mutation_p.Q524E|TMEM67_uc011lgl.1_Missense_Mutation_p.Q4E	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	605					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AATGCCAATTCAGGAAGAACG	0.323													0	0	0	1	0	30	71										G	94808168	C	G	94808168	3	3	65	1	0	0	0	0	1	0	0	0	16193	827	29	1	2021	1	TMEM67	8	94808168	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1835510	94808168	51555854	646	19679										
KIAA1429	25962	broad.mit.edu	37	chr8	95527162	95527162	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctaaggtttttcagaggttCaagccacttgccaagttctt	8	9	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:95527162C>A	uc003ygo.1	-	11	2699	c.2686G>T	c.(2686-2688)GAA>TAA	p.E896*	KIAA1429_uc003ygp.2_Nonsense_Mutation_p.E896*|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	896					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTCAGAGGTTCAAGCCACTTG	0.259													1	0	0.0581538	1	0.0583952	10	14										A	95527162	C	A	95527162	4	1	65	1	0	0	0	0	0	1	0	0	8231	835	29	3	2862	3	KIAA1429	8	95527162	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	718994	95527162	50836860	647	19680										
UBR5	51366	broad.mit.edu	37	chr8	103266703	103266703	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cataggctggaatccttcttCactggctggcagtgatgggc	13	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:103266703C>T	uc003ykr.1	-	59	8260	c.8227G>A	c.(8227-8229)GAA>AAA	p.E2743K	UBR5_uc003yks.1_Missense_Mutation_p.E2742K|UBR5_uc003ykq.2_Missense_Mutation_p.E254K	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2743	Pro-rich.|HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AATCCTTCTTCACTGGCTGGC	0.418													0	0	0	1	0	15	46										T	103266703	C	T	103266703	3	4	65	1	0	0	0	0	1	0	0	0	16902	835	29	1	176	1	UBR5	8	103266703	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7739541	103266703	43097319	648	19681										
CSMD3	114788	broad.mit.edu	37	chr8	113504853	113504853	+	Frame_Shift_Del	DEL	T	T	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaccctaatttataatccaTtccaagtctggtgccattca							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:113504853delT	uc003ynu.2	-	31	5302	c.5143delA	c.(5143-5145)ATGfs	p.M1715fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.M987fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.M1675fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.M1611fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1715	Extracellular (Potential).|Sushi 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTATAATCCATTCCAAGTCTG	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)								22	83	---	---								-	113504853	T	-	113504853	7	5	65	1	0	1	0	1	0	0	0	0	3946	1493	52	0	6144	0	CSMD3	8	113504853	Frame_Shift_Del	DEL	T	TCGA-DK-A3WW-01A-22D-A23M-08	10238150	113504853	32859169	649	19682										
EXT1	2131	broad.mit.edu	37	chr8	118847773	118847773	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcccatccattgctgagcatCacagggacgcaggcagcctg	11	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:118847773C>T	uc003yok.1	-	3	1847	c.1074G>A	c.(1072-1074)GTG>GTA	p.V358V		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	358	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TGCTGAGCATCACAGGGACGC	0.478			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				0	0	0	1	0	15	41										T	118847773	C	T	118847773	2	4	65	1	0	0	0	0	0	0	0	1	5323	813	29	1		1	EXT1	8	118847773	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5342920	118847773	27516249	650	19683										
COL14A1	7373	broad.mit.edu	37	chr8	121282363	121282363	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaataagatcatcagctttCtatacagcactgttggagcc	7	10	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:121282363C>A	uc003yox.2	+	26	3428	c.3163C>A	c.(3163-3165)CTA>ATA	p.L1055I	COL14A1_uc003yoz.2_Missense_Mutation_p.L20I	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1055	VWFA 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CATCAGCTTTCTATACAGCAC	0.383													1	0	3.59834e-05	1	3.66325e-05	6	36										A	121282363	C	A	121282363	3	1	65	1	0	0	0	0	1	0	0	0	3671	912	32	3	3261	3	COL14A1	8	121282363	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2434590	121282363	25081659	651	19684										
WDR67	93594	broad.mit.edu	37	chr8	124146406	124146406	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccagagacctagaaatgaGacagctggaactcgaatcac	10	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:124146406G>C	uc003ypp.1	+	17	2549	c.2459G>C	c.(2458-2460)AGA>ACA	p.R820T	WDR67_uc011lig.1_Intron|WDR67_uc011lih.1_Missense_Mutation_p.R710T|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.R454T|WDR67_uc003ypt.1_Missense_Mutation_p.R277T|WDR67_uc003ypu.1_Missense_Mutation_p.R277T	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	820	Potential.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CTAGAAATGAGACAGCTGGAA	0.313													0	0	0	1	0	27	69										C	124146406	G	C	124146406	3	2	65	1	0	0	0	0	1	0	0	0	17315	942	33	1	2525	1	WDR67	8	124146406	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2864043	124146406	22217616	652	19685										
FER1L6	654463	broad.mit.edu	37	chr8	124968267	124968267	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgaaggtgaagaagaagaGaaataaggcagagaaggggt	17	2	0	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:124968267G>C	uc003yqw.2	+	2	235	c.29G>C	c.(28-30)AGA>ACA	p.R10T		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	10	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAGAAGAAGAGAAATAAGGCA	0.463													0	0	0	1	0	9	23										C	124968267	G	C	124968267	3	2	65	1	0	0	0	0	1	0	0	0	5815	942	33	1	31	1	FER1L6	8	124968267	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	821861	124968267	21395755	653	19686										
NDUFB9	4715	broad.mit.edu	37	chr8	125555327	125555327	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaaaatcattttggtttaaGagacaaataccgatactttg	6	6	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:125555327G>C	uc003yrg.3	+	2	187	c.102_splice	c.e2-1	p.R34_splice	NDUFB9_uc011lim.1_Splice_Site_p.R34_splice	NM_005005	NP_004996	Q9Y6M9	NDUB9_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta						mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|skin(1)	2	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)		NADH(DB00157)	TTTGGTTTAAGAGACAAATAC	0.453													0	0	0	1	0	14	63										C	125555327	G	C	125555327	5	2	65	1	0	0	0	0	0	0	1	0	10288	956	33	1	107	1	NDUFB9	8	125555327	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	587060	125555327	20808695	654	19687										
NDUFB9	4715	broad.mit.edu	37	chr8	125555347	125555347	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagacaaataccgatactttGcttgtttgatgagagcccgg	11	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:125555347G>C	uc003yrg.3	+	2	206	c.121G>C	c.(121-123)GCT>CCT	p.A41P	NDUFB9_uc011lim.1_Missense_Mutation_p.A41P	NM_005005	NP_004996	Q9Y6M9	NDUB9_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	41					mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|skin(1)	2	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)		NADH(DB00157)	CCGATACTTTGCTTGTTTGAT	0.448													0	0	0	1	0	15	67										C	125555347	G	C	125555347	3	2	65	1	0	0	0	0	1	0	0	0	10288	1319	46	4	127	4	NDUFB9	8	125555347	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	20	125555347	20808675	655	19688										
KIAA0196	9897	broad.mit.edu	37	chr8	126036882	126036882	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcactgttctgaactcatCaaaaatgaaattaggcacat	6	9	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:126036882C>T	uc003yrt.2	-	29	3786	c.3457G>A	c.(3457-3459)GAT>AAT	p.D1153N	KIAA0196_uc011lir.1_Missense_Mutation_p.D1005N	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	1153					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTGAACTCATCAAAAATGAAA	0.318													0	0	0	1	0	10	39										T	126036882	C	T	126036882	3	4	65	1	0	0	0	0	1	0	0	0	8161	826	29	1	26	1	KIAA0196	8	126036882	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	481535	126036882	20327140	656	19689										
ASAP1	50807	broad.mit.edu	37	chr8	131073251	131073251	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgccaactgtgatgatttCtgaaagatttcgggcgggat	12	7	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:131073251C>T	uc003yta.1	-	27	2794	c.2766G>A	c.(2764-2766)CAG>CAA	p.Q922Q	ASAP1_uc003ysz.1_Silent_p.Q733Q|ASAP1_uc011liw.1_Silent_p.Q915Q	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	922	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						GTGATGATTTCTGAAAGATTT	0.512													0	0	0	1	0	42	145										T	131073251	C	T	131073251	2	4	65	1	0	0	0	0	0	0	0	1	1010	912	32	1		1	ASAP1	8	131073251	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5036369	131073251	15290771	657	19690										
ADCY8	114	broad.mit.edu	37	chr8	132052131	132052131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggtggggaaaatgacccctCggtagctatagcccccatta	12	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:132052131C>T	uc003ytd.3	-	1	705	c.449G>A	c.(448-450)CGA>CAA	p.R150Q	ADCY8_uc010mds.2_Missense_Mutation_p.R150Q	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	150	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AATGACCCCTCGGTAGCTATA	0.577										HNSCC(32;0.087)			0	0	0	1	0	17	29										T	132052131	C	T	132052131	3	4	65	1	0	0	0	0	1	0	0	0	300	884	31	1	3378	1	ADCY8	8	132052131	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	978880	132052131	14311891	658	19691										
TMEM71	137835	broad.mit.edu	37	chr8	133740098	133740098	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaagctgtcaactgggactGaagagacaagctatgggagt	14	6	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:133740098G>A	uc003ytp.2	-	6	848	c.619C>T	c.(619-621)CAG>TAG	p.Q207*	TMEM71_uc003ytm.1_Nonsense_Mutation_p.Q29*|TMEM71_uc003ytn.2_Nonsense_Mutation_p.Q189*|TMEM71_uc003yto.2_Intron	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	208						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AACTGGGACTGAAGAGACAAG	0.463													0	0	0	1	0	38	112										A	133740098	G	A	133740098	4	1	65	1	0	0	0	0	0	1	0	0	16197	1299	45	1	285	1	TMEM71	8	133740098	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1687967	133740098	12623924	659	19692										
EIF2C2	27161	broad.mit.edu	37	chr8	141568637	141568637	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagacgcggtacttcctcttCatctgcccacagtgcgttat	8	14	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:141568637C>T	uc003yvn.2	-	7	865	c.825G>A	c.(823-825)ATG>ATA	p.M275I	EIF2C2_uc010men.2_Missense_Mutation_p.M198I|EIF2C2_uc010meo.2_Missense_Mutation_p.M275I	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	275	PAZ.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			ACTTCCTCTTCATCTGCCCAC	0.612													0	0	0	1	0	30	108										T	141568637	C	T	141568637	3	4	65	1	0	0	0	0	1	0	0	0	5006	826	29	1	1806	1	EIF2C2	8	141568637	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7828539	141568637	4795385	660	19693										
TSNARE1	203062	broad.mit.edu	37	chr8	143396400	143396400	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagcactgaatggcatctgaGagctgggttttcagccggtc	13	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:143396400G>C	uc003ywk.2	-	8	1156	c.1038C>G	c.(1036-1038)CTC>CTG	p.L346L	TSNARE1_uc011lju.1_Silent_p.L345L|TSNARE1_uc003ywj.2_Silent_p.L346L|TSNARE1_uc003ywl.3_Silent_p.L126L	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	346					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGGCATCTGAGAGCTGGGTTT	0.652													0	0	0	1	0	21	103										C	143396400	G	C	143396400	2	2	65	1	0	0	0	0	0	0	0	1	16627	929	33	1		1	TSNARE1	8	143396400	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1827763	143396400	2967622	661	19694										
TIGD5	84948	broad.mit.edu	37	chr8	144681737	144681737	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgggcccagccctgccccCtgcagcgcctccggccccag	13	21	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:144681737C>T	uc003yyx.1	+	1	1517	c.1517C>T	c.(1516-1518)CCT>CTT	p.P506L	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	555					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GCCCTGCCCCCTGCAGCGCCT	0.716													0	0	0	1	0	3	11										T	144681737	C	T	144681737	3	4	65	1	0	0	0	0	1	0	0	0	15896	681	24	2	1666	2	TIGD5	8	144681737	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1285337	144681737	1682285	662	19695										
PLEC	5339	broad.mit.edu	37	chr8	145003979	145003979	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagggcttggcgctgctcctCtggcttcagggtgcggaact	15	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:145003979C>G	uc003zaf.1	-	23	3339	c.3169G>C	c.(3169-3171)GAG>CAG	p.E1057Q	PLEC_uc003zab.1_Missense_Mutation_p.E920Q|PLEC_uc003zac.1_Missense_Mutation_p.E924Q|PLEC_uc003zad.2_Missense_Mutation_p.E920Q|PLEC_uc003zae.1_Missense_Mutation_p.E888Q|PLEC_uc003zag.1_Missense_Mutation_p.E898Q|PLEC_uc003zah.2_Missense_Mutation_p.E906Q|PLEC_uc003zaj.2_Missense_Mutation_p.E947Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1057	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCTGCTCCTCTGGCTTCAGG	0.706													0	0	0	1	0	9	23										G	145003979	C	G	145003979	3	3	65	1	0	0	0	0	1	0	0	0	12052	922	32	1	10925	1	PLEC	8	145003979	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	322242	145003979	1360043	663	19696										
PLEC	5339	broad.mit.edu	37	chr8	145004382	145004382	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacggagggcacggcggcctCgctgccggagctgctgagca	17	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:145004382C>A	uc003zaf.1	-	21	3123	c.2953G>T	c.(2953-2955)GAG>TAG	p.E985*	PLEC_uc003zab.1_Nonsense_Mutation_p.E848*|PLEC_uc003zac.1_Nonsense_Mutation_p.E852*|PLEC_uc003zad.2_Nonsense_Mutation_p.E848*|PLEC_uc003zae.1_Nonsense_Mutation_p.E816*|PLEC_uc003zag.1_Nonsense_Mutation_p.E826*|PLEC_uc003zah.2_Nonsense_Mutation_p.E834*|PLEC_uc003zaj.2_Nonsense_Mutation_p.E875*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	985	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						ACGGCGGCCTCGCTGCCGGAG	0.716													1	0	0.184627	1	0.184846	5	13										A	145004382	C	A	145004382	4	1	65	1	0	0	0	0	0	1	0	0	12052	893	31	3	11149	3	PLEC	8	145004382	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	403	145004382	1359640	664	19697										
GRINA	2907	broad.mit.edu	37	chr8	145066917	145066917	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcagctgtccctgagcccaGaagagtatgtgtttgctgcg	13	10	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:145066917G>A	uc003zan.1	+	7	1190	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K	GRINA_uc003zao.1_Missense_Mutation_p.E342K|GRINA_uc003zap.1_Missense_Mutation_p.E342K	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	342						integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCTGAGCCCAGAAGAGTATGT	0.562													0	0	0	1	0	11	45										A	145066917	G	A	145066917	3	1	65	1	0	0	0	0	1	0	0	0	6785	943	33	1	1046	1	GRINA	8	145066917	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	62535	145066917	1297105	665	19698										
MFSD3	113655	broad.mit.edu	37	chr8	145736434	145736434	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaagctgctgctgggcactCtggccggaggcctggctgat	17	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr8:145736434C>T	uc003zdi.1	+	5	1291	c.1126C>T	c.(1126-1128)CTG>TTG	p.L376L		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	376	Leu-rich.|Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCTGGGCACTCTGGCCGGAGG	0.647													0	0	0	1	0	47	151										T	145736434	C	T	145736434	2	4	65	1	0	0	0	0	0	0	0	1	9532	912	32	1		1	MFSD3	8	145736434	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	669517	145736434	627588	666	19699										
DMRT3	58524	broad.mit.edu	37	chr9	990886	990886	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccgcgccacggaagaccctCggatttccatccctgatgat	9	16	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:990886C>T	uc003zgw.1	+	2	1338	c.1300C>T	c.(1300-1302)CGG>TGG	p.R434W		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	434					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GGAAGACCCTCGGATTTCCAT	0.542													0	0	0	1	0	27	100										T	990886	C	T	990886	3	4	65	1	0	0	0	0	1	0	0	0	4587	875	31	1	1306	1	DMRT3	9	990886	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		990886	140222545	667	19700										
SMARCA2	6595	broad.mit.edu	37	chr9	2056767	2056767	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggagcaagcgccagactctGagagaagctcgcatgaccga	13	12	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:2056767G>C	uc003zhc.2	+	7	1368	c.1269G>C	c.(1267-1269)CTG>CTC	p.L423L	SMARCA2_uc003zhd.2_Silent_p.L423L|SMARCA2_uc010mha.2_Silent_p.L414L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	423					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCCAGACTCTGAGAGAAGCTC	0.572													0	0	0	1	0	15	29										C	2056767	G	C	2056767	2	2	65	1	0	0	0	0	0	0	0	1	14769	1277	45	1		1	SMARCA2	9	2056767	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1065881	2056767	139156664	668	19701										
KIAA0020	9933	broad.mit.edu	37	chr9	2837350	2837350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctagatgtgactttaggtCcaccttctttagcaactttc	6	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:2837350C>T	uc003zhp.1	-	3	230	c.134G>A	c.(133-135)GGA>GAA	p.G45E	KIAA0020_uc010mhc.1_Missense_Mutation_p.G44E|KIAA0020_uc003zhq.1_Missense_Mutation_p.G45E	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	45						endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		GACTTTAGGTCCACCTTCTTT	0.373													0	0	0	1	0	17	79										T	2837350	C	T	2837350	3	4	65	1	0	0	0	0	1	0	0	0	8152	855	30	1	1876	1	KIAA0020	9	2837350	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	780583	2837350	138376081	669	19702										
JAK2	3717	broad.mit.edu	37	chr9	5022040	5022040	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggagggaacatccacctcttCtatatatcagaatggtgata	9	8	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:5022040C>G	uc010mhm.2	+	2	166	c.53C>G	c.(52-54)TCT>TGT	p.S18C	JAK2_uc003ziw.2_Missense_Mutation_p.S18C	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	18	Interaction with cytokine/interferon/growth hormone receptors (By similarity).				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TCCACCTCTTCTATATATCAG	0.393		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				0	0	0	1	0	24	77										G	5022040	C	G	5022040	3	3	65	1	0	0	0	0	1	0	0	0	7938	913	32	1	55	1	JAK2	9	5022040	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2184690	5022040	136191391	670	19703										
KIAA1432	57589	broad.mit.edu	37	chr9	5765728	5765728	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagtttatcccagtcagctGaaaatgttcctgccagtaaa	7	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:5765728G>A	uc003zji.2	+	20	2923	c.2830G>A	c.(2830-2832)GAA>AAA	p.E944K	KIAA1432_uc003zjh.2_Missense_Mutation_p.E944K|KIAA1432_uc003zjl.3_Missense_Mutation_p.E907K|KIAA1432_uc003zjj.1_Missense_Mutation_p.E486K|ERMP1_uc011lme.1_RNA	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1023						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CCAGTCAGCTGAAAATGTTCC	0.398													0	0	0	1	0	10	126										A	5765728	G	A	5765728	3	1	65	1	0	0	0	0	1	0	0	0	8233	1291	45	1	2908	1	KIAA1432	9	5765728	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	743688	5765728	135447703	671	19704										
PTPRD	5789	broad.mit.edu	37	chr9	8484270	8484270	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccaccagcactgtttccacGatttgtcagcacaaatgaat	6	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:8484270G>A	uc003zkk.2	-	29	3973	c.3262C>T	c.(3262-3264)CGT>TGT	p.R1088C	PTPRD_uc003zkp.2_Missense_Mutation_p.R677C|PTPRD_uc003zkq.2_Missense_Mutation_p.R677C|PTPRD_uc003zkr.2_Missense_Mutation_p.R672C|PTPRD_uc003zks.2_Missense_Mutation_p.R667C|PTPRD_uc003zkl.2_Missense_Mutation_p.R1079C|PTPRD_uc003zkm.2_Missense_Mutation_p.R1075C|PTPRD_uc003zkn.2_Missense_Mutation_p.R677C|PTPRD_uc003zko.2_Missense_Mutation_p.R674C	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1088	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGTTTCCACGATTTGTCAGC	0.478										TSP Lung(15;0.13)			0	0	0	1	0	20	65										A	8484270	G	A	8484270	3	1	65	1	0	0	0	0	1	0	0	0	12799	1058	37	1	2609	1	PTPRD	9	8484270	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2718542	8484270	132729161	672	19705										
BNC2	54796	broad.mit.edu	37	chr9	16436824	16436824	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acagcattgtaatgaattttGagagtacctttgtcatagaa	8	5	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:16436824G>C	uc003zml.2	-	6	1508	c.1368C>G	c.(1366-1368)CTC>CTG	p.L456L	BNC2_uc011lmw.1_Silent_p.L361L|BNC2_uc003zmm.2_Silent_p.L414L|BNC2_uc003zmq.1_Silent_p.L470L|BNC2_uc003zmr.1_Silent_p.L493L|BNC2_uc003zmp.1_Silent_p.L484L|BNC2_uc010mij.1_Silent_p.L378L|BNC2_uc011lmv.1_Silent_p.L282L|BNC2_uc003zmo.1_Silent_p.L378L|BNC2_uc003zmj.2_Silent_p.L221L|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.L221L|BNC2_uc003zmn.1_Silent_p.L221L	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	456	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		AATGAATTTTGAGAGTACCTT	0.448													0	0	0	1	0	26	68										C	16436824	G	C	16436824	2	2	65	1	0	0	0	0	0	0	0	1	1475	1277	45	1		1	BNC2	9	16436824	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7952554	16436824	124776607	673	19706										
CNTLN	54875	broad.mit.edu	37	chr9	17464510	17464510	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaaggatatctcgaatggaGagggatataactatgaaaag	11	4	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:17464510G>A	uc003zmz.2	+	21	3443	c.3417G>A	c.(3415-3417)GAG>GAA	p.E1139E	CNTLN_uc003zmy.2_Silent_p.E1140E|CNTLN_uc010mio.2_Silent_p.E819E	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1140	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		CTCGAATGGAGAGGGATATAA	0.303													0	0	0	1	0	16	34										A	17464510	G	A	17464510	2	1	65	1	0	0	0	0	0	0	0	1	3639	933	33	1		1	CNTLN	9	17464510	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1027686	17464510	123748921	674	19707										
DENND4C	55667	broad.mit.edu	37	chr9	19345995	19345995	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcgaagctactaatctcaaGaagaatggtgatagaggaga	13	5	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:19345995G>C	uc003znq.2	+	18	2406	c.2373G>C	c.(2371-2373)AAG>AAC	p.K791N	DENND4C_uc011lnc.1_Missense_Mutation_p.K121N|DENND4C_uc011lnd.1_Missense_Mutation_p.K79N|DENND4C_uc003znr.2_Missense_Mutation_p.K79N|DENND4C_uc003zns.2_5'UTR|DENND4C_uc003znt.2_5'UTR	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	791						integral to membrane				ovary(1)|skin(1)	2						CTAATCTCAAGAAGAATGGTG	0.358													0	0	0	1	0	19	65										C	19345995	G	C	19345995	3	2	65	1	0	0	0	0	1	0	0	0	4435	933	33	1	2443	1	DENND4C	9	19345995	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1881485	19345995	121867436	675	19708										
DENND4C	55667	broad.mit.edu	37	chr9	19346457	19346457	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccaaagatctgaggaataaGagaagtagtttatatggtat	10	3	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:19346457G>C	uc003znq.2	+	18	2868	c.2835G>C	c.(2833-2835)AAG>AAC	p.K945N	DENND4C_uc011lnc.1_Missense_Mutation_p.K275N|DENND4C_uc011lnd.1_Missense_Mutation_p.K233N|DENND4C_uc003znr.2_Missense_Mutation_p.K233N|DENND4C_uc003zns.2_Missense_Mutation_p.K127N|DENND4C_uc003znt.2_Missense_Mutation_p.K127N	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	945						integral to membrane				ovary(1)|skin(1)	2						TGAGGAATAAGAGAAGTAGTT	0.378													0	0	0	1	0	12	70										C	19346457	G	C	19346457	3	2	65	1	0	0	0	0	1	0	0	0	4435	933	33	1	2905	1	DENND4C	9	19346457	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	462	19346457	121866974	676	19709										
RPS6	6194	broad.mit.edu	37	chr9	19376564	19376564	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcttggtacgctgcttcttCagagcaatacgccgccgttt	9	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:19376564C>G	uc003znv.1	-	5	624	c.582G>C	c.(580-582)CTG>CTC	p.L194L	RPS6_uc003znu.1_Silent_p.L163L	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	194					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		GCTGCTTCTTCAGAGCAATAC	0.448													0	0	0	1	0	26	105										G	19376564	C	G	19376564	2	3	65	1	0	0	0	0	0	0	0	1	13649	813	29	1		1	RPS6	9	19376564	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	30107	19376564	121836867	677	19710										
SLC24A2	25769	broad.mit.edu	37	chr9	19786586	19786586	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtggagtataatccagaatCttgtcatttaaatctaagag	8	5	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:19786586C>G	uc003zoa.1	-	1	341	c.279G>C	c.(277-279)AAG>AAC	p.K93N	SLC24A2_uc003zob.1_Missense_Mutation_p.K93N	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	93	Extracellular (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		AATCCAGAATCTTGTCATTTA	0.473													0	0	0	1	0	18	86										G	19786586	C	G	19786586	3	3	65	1	0	0	0	0	1	0	0	0	14466	912	32	1	1746	1	SLC24A2	9	19786586	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	410022	19786586	121426845	678	19711										
TMEM215	401498	broad.mit.edu	37	chr9	32784684	32784684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctggacggctactgcccctCgggcagttccctcacctaca	9	18	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:32784684C>T	uc003zri.3	+	2	868	c.503C>T	c.(502-504)TCG>TTG	p.S168L		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	168						integral to membrane					0						TACTGCCCCTCGGGCAGTTCC	0.587													0	0	0	1	0	22	44										T	32784684	C	T	32784684	3	4	65	1	0	0	0	0	1	0	0	0	16135	893	31	1	505	1	TMEM215	9	32784684	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	12998098	32784684	108428747	679	19712										
DNAI1	27019	broad.mit.edu	37	chr9	34489432	34489432	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacggcggcagcattaccgcGatgaattagtggcaggtagg	16	8	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:34489432G>C	uc003zum.2	+	5	566	c.373G>C	c.(373-375)GAT>CAT	p.D125H		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	125					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		GCATTACCGCGATGAATTAGT	0.527									Kartagener_syndrome				0	0	0	1	0	19	83										C	34489432	G	C	34489432	3	2	65	1	0	0	0	0	1	0	0	0	4609	1058	37	1	391	1	DNAI1	9	34489432	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1704748	34489432	106723999	680	19713										
POLR1E	64425	broad.mit.edu	37	chr9	37498107	37498107	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccattgcacctttgtcataGaagcgttgaagtctttgcca	9	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:37498107G>A	uc003zzz.1	+	8	1246	c.958G>A	c.(958-960)GAA>AAA	p.E320K	POLR1E_uc003zzy.1_Missense_Mutation_p.E258K|POLR1E_uc011lqk.1_Missense_Mutation_p.E187K	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	320					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		CTTTGTCATAGAAGCGTTGAA	0.483													0	0	0	1	0	27	54										A	37498107	G	A	37498107	3	1	65	1	0	0	0	0	1	0	0	0	12213	943	33	1	806	1	POLR1E	9	37498107	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3008675	37498107	103715324	681	19714										
C9orf71	169693	broad.mit.edu	37	chr9	71155605	71155605	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaggcagaagcaaataggcCgcaatcaggctcccctgaca	11	12	1	3	rs147451213		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:71155605C>T	uc004agt.2	-	1	179	c.126G>A	c.(124-126)GCG>GCA	p.A42A		NM_153237	NP_694969	Q8N6L7	CI071_HUMAN	hypothetical protein LOC169693	42	Helical; (Potential).					integral to membrane					0						GCAAATAGGCCGCAATCAGGC	0.532													0	0	0	1	0	4	46										T	71155605	C	T	71155605	2	4	65	1	0	0	0	0	0	0	0	1	2494	639	23	2		2	C9orf71	9	71155605	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	33657498	71155605	70057826	682	19715										
TJP2	9414	broad.mit.edu	37	chr9	71851902	71851902	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgttcaaaatgcccagagaGacaacgctggggaccgggca	14	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:71851902G>C	uc004ahe.2	+	14	2229	c.2029G>C	c.(2029-2031)GAC>CAC	p.D677H	TJP2_uc011lrs.1_Missense_Mutation_p.D654H|TJP2_uc011lrt.1_Missense_Mutation_p.D654H|TJP2_uc004ahd.2_Missense_Mutation_p.D677H|TJP2_uc004ahf.2_Missense_Mutation_p.D677H|TJP2_uc011lru.1_Missense_Mutation_p.D681H|TJP2_uc011lrv.1_Missense_Mutation_p.D699H	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	677					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						TGCCCAGAGAGACAACGCTGG	0.498													0	0	0	1	0	44	175										C	71851902	G	C	71851902	3	2	65	1	0	0	0	0	1	0	0	0	15927	942	33	1	2240	1	TJP2	9	71851902	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	696297	71851902	69361529	683	19716			2	88		3	3	130	G		1.720692e-05
TJP2	9414	broad.mit.edu	37	chr9	71851923	71851923	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaacgctggggaccgggcaGatttctggagaatgcgtggc	16	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:71851923G>A	uc004ahe.2	+	14	2250	c.2050G>A	c.(2050-2052)GAT>AAT	p.D684N	TJP2_uc011lrs.1_Missense_Mutation_p.D661N|TJP2_uc011lrt.1_Missense_Mutation_p.D661N|TJP2_uc004ahd.2_Missense_Mutation_p.D684N|TJP2_uc004ahf.2_Missense_Mutation_p.D684N|TJP2_uc011lru.1_Missense_Mutation_p.D688N|TJP2_uc011lrv.1_Missense_Mutation_p.D706N	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	684	Guanylate kinase-like.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						GGACCGGGCAGATTTCTGGAG	0.512													0	0	0	1	0	41	173										A	71851923	G	A	71851923	3	1	65	1	0	0	0	0	1	0	0	0	15927	942	33	1	2261	1	TJP2	9	71851923	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	21	71851923	69361508	684	19717			2	88		3	3	130	G		1.720692e-05
TJP2	9414	broad.mit.edu	37	chr9	71852031	71852031	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaccaagttcccagcttatGagagggttttgctgcgagaa	12	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:71852031G>C	uc004ahe.2	+	14	2358	c.2158G>C	c.(2158-2160)GAG>CAG	p.E720Q	TJP2_uc011lrs.1_Missense_Mutation_p.E697Q|TJP2_uc011lrt.1_Missense_Mutation_p.E697Q|TJP2_uc004ahd.2_Missense_Mutation_p.E720Q|TJP2_uc004ahf.2_Missense_Mutation_p.E720Q|TJP2_uc011lru.1_Missense_Mutation_p.E724Q|TJP2_uc011lrv.1_Missense_Mutation_p.E742Q	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	720	Guanylate kinase-like.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						CCCAGCTTATGAGAGGGTTTT	0.517													0	0	0	1	0	24	112										C	71852031	G	C	71852031	3	2	65	1	0	0	0	0	1	0	0	0	15927	1291	45	1	2369	1	TJP2	9	71852031	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	108	71852031	69361400	685	19718			2	88		3	3	130	G		1.720692e-05
GDA	9615	broad.mit.edu	37	chr9	74764516	74764516	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcccctggcgcacatcttccGagggacgttcgtccactcca	10	17	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:74764516G>T	uc004aiq.2	+	1	224	c.41G>T	c.(40-42)CGA>CTA	p.R14L	GDA_uc011lse.1_Intron|GDA_uc011lsf.1_5'UTR|GDA_uc004air.2_Missense_Mutation_p.R14L|GDA_uc010mow.1_RNA|GDA_uc004ais.2_5'UTR	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	14					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		CACATCTTCCGAGGGACGTTC	0.701													1	0	1.33834e-09	1	1.3952e-09	18	29										T	74764516	G	T	74764516	3	4	65	1	0	0	0	0	1	0	0	0	6306	1058	37	3	43	3	GDA	9	74764516	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2912485	74764516	66448915	686	19719										
TRPM6	140803	broad.mit.edu	37	chr9	77416817	77416817	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagagagaacacttactttGagtaattcttcaactcttct	6	8	4	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:77416817G>C	uc004ajl.1	-	16	2244	c.2006C>G	c.(2005-2007)TCA>TGA	p.S669*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.S664*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_Nonsense_Mutation_p.S47*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	669	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CACTTACTTTGAGTAATTCTT	0.408													0	0	0	1	0	18	66										C	77416817	G	C	77416817	4	2	65	1	0	0	0	0	0	1	0	0	16587	1294	45	1	4158	1	TRPM6	9	77416817	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2652301	77416817	63796614	687	19720										
KIF27	55582	broad.mit.edu	37	chr9	86474218	86474218	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggtctggagctgcacattCttttcagacaactcttgttc	8	11	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:86474218C>G	uc004ana.2	-	14	3147	c.3003G>C	c.(3001-3003)AAG>AAC	p.K1001N	KIF27_uc010mpw.2_Missense_Mutation_p.K935N|KIF27_uc010mpx.2_Missense_Mutation_p.K904N	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1001	Potential.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						GCTGCACATTCTTTTCAGACA	0.423													0	0	0	1	0	19	79										G	86474218	C	G	86474218	3	3	65	1	0	0	0	0	1	0	0	0	8296	912	32	1	1222	1	KIF27	9	86474218	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	9057401	86474218	54739213	688	19721										
AGTPBP1	23287	broad.mit.edu	37	chr9	88247959	88247959	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtaaaacctggggctgtttGagaaggaatattctgcaatg	12	5	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:88247959G>A	uc011ltd.1	-	13	1666	c.1633C>T	c.(1633-1635)CAA>TAA	p.Q545*	AGTPBP1_uc004aod.3_Nonsense_Mutation_p.Q171*|AGTPBP1_uc011ltc.1_Nonsense_Mutation_p.Q443*|AGTPBP1_uc010mqc.2_Nonsense_Mutation_p.Q505*|AGTPBP1_uc011lte.1_Nonsense_Mutation_p.Q557*	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	545					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						GGGGCTGTTTGAGAAGGAATA	0.423													0	0	0	1	0	15	56										A	88247959	G	A	88247959	4	1	65	1	0	0	0	0	0	1	0	0	400	1299	45	1	2099	1	AGTPBP1	9	88247959	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1773741	88247959	52965472	689	19722										
C9orf79	286234	broad.mit.edu	37	chr9	90497818	90497818	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgaaggcgatgggaaatctCgtcatccctctagggaaggg	14	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:90497818C>T	uc004app.3	+	1	47	c.12C>T	c.(10-12)CTC>CTT	p.L4L	C9orf79_uc004apo.1_Silent_p.L4L	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	4						integral to membrane				ovary(3)	3						TGGGAAATCTCGTCATCCCTC	0.607													0	0	0	1	0	17	39										T	90497818	C	T	90497818	2	4	65	1	0	0	0	0	0	0	0	1	2497	871	31	1		1	C9orf79	9	90497818	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2249859	90497818	50715613	690	19723										
SPTLC1	10558	broad.mit.edu	37	chr9	94809914	94809914	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctgatggtcaattacaaaaGacctgccacagcagaaacct	7	12	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:94809914G>C	uc004arl.1	-	10	1003	c.965C>G	c.(964-966)TCT>TGT	p.S322C	SPTLC1_uc011ltv.1_Missense_Mutation_p.S322C	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	322	Cytoplasmic (Potential).					integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AATTACAAAAGACCTGCCACA	0.388													0	0	0	1	0	5	19										C	94809914	G	C	94809914	3	2	65	1	0	0	0	0	1	0	0	0	15122	942	33	1	480	1	SPTLC1	9	94809914	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4312096	94809914	46403517	691	19724										
ZNF484	83744	broad.mit.edu	37	chr9	95610035	95610035	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagaatgaattctctggcatCtgaacagatctgacttctgg	9	9	4	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:95610035C>T	uc004asu.1	-	5	1183	c.1034G>A	c.(1033-1035)AGA>AAA	p.R345K	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.R347K|ZNF484_uc010mrb.1_Missense_Mutation_p.R309K|ZNF484_uc004asv.1_Missense_Mutation_p.R309K	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	345	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTCTGGCATCTGAACAGATC	0.363													0	0	0	1	0	15	47										T	95610035	C	T	95610035	3	4	65	1	0	0	0	0	1	0	0	0	17934	913	32	1	1528	1	ZNF484	9	95610035	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	800121	95610035	45603396	692	19725										
CTSL2	1515	broad.mit.edu	37	chr9	99795232	99795232	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcctcaccatccatcagctCacacattggggtagctggct	8	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:99795232C>T	uc004awt.2	-	8	1201	c.1004G>A	c.(1003-1005)TGA>TAA	p.*335*	CTSL2_uc010msi.2_Silent_p.*335*|CTSL2_uc004awu.2_Silent_p.*280*	NM_001333	NP_001324	O60911	CATL2_HUMAN	cathepsin L2 preproprotein	335						lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(62;0.0559)				TCCATCAGCTCACACATTGGG	0.468													0	0	0	1	0	11	51										T	99795232	C	T	99795232	2	4	65	1	0	0	0	0	0	0	0	1	4039	837	29	1		1	CTSL2	9	99795232	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4185197	99795232	41418199	693	19726										
NCBP1	4686	broad.mit.edu	37	chr9	100417166	100417166	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatcctaaattcacagcttgCacaggcaactgaaatgctat	6	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:100417166C>T	uc004axq.2	+	12	1634	c.1175C>T	c.(1174-1176)GCA>GTA	p.A392V		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	392					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				TCACAGCTTGCACAGGCAACT	0.358													0	0	0	1	0	11	38										T	100417166	C	T	100417166	3	4	65	1	0	0	0	0	1	0	0	0	10211	710	25	2	1221	2	NCBP1	9	100417166	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	621934	100417166	40796265	694	19727										
ABCA1	19	broad.mit.edu	37	chr9	107571819	107571819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcgtttaagagttccaggGttcccgtgtcctcaggagca	14	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:107571819G>A	uc004bcl.2	-	30	4515	c.4202C>T	c.(4201-4203)ACC>ATC	p.T1401I		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1401	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAGTTCCAGGGTTCCCGTGTC	0.483													0	0	0	1	0	10	35										A	107571819	G	A	107571819	3	1	65	1	0	0	0	0	1	0	0	0	28	1261	44	2	2667	2	ABCA1	9	107571819	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7154653	107571819	33641612	695	19728										
RAD23B	5887	broad.mit.edu	37	chr9	110086268	110086268	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttccagcgttactacagcaGataggtcgagagaatcctca	9	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:110086268G>C	uc004bde.2	+	8	1282	c.915G>C	c.(913-915)CAG>CAC	p.Q305H	RAD23B_uc011lwa.1_Missense_Mutation_p.Q305H|RAD23B_uc011lwb.1_Missense_Mutation_p.Q284H	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	305	STI1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						TACTACAGCAGATAGGTCGAG	0.408								Direct_reversal_of_damage|NER					0	0	0	1	0	15	46										C	110086268	G	C	110086268	3	2	65	1	0	0	0	0	1	0	0	0	12983	933	33	1	945	1	RAD23B	9	110086268	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2514449	110086268	31127163	696	19729										
PTPN3	5774	broad.mit.edu	37	chr9	112153421	112153421	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagattcctaacttacgttCacgtaacttgcattaatata	4	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:112153421C>T	uc004bed.2	-	21	2215	c.2103G>A	c.(2101-2103)GTG>GTA	p.V701V	PTPN3_uc004beb.2_Silent_p.V570V|PTPN3_uc004bec.2_Silent_p.V525V|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.V656V|PTPN3_uc011lwh.1_Silent_p.V547V|PTPN3_uc011lwd.1_Silent_p.V169V|PTPN3_uc011lwe.1_Silent_p.V414V|PTPN3_uc011lwf.1_Silent_p.V369V	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	701	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AACTTACGTTCACGTAACTTG	0.358													0	0	0	1	0	7	19										T	112153421	C	T	112153421	2	4	65	1	0	0	0	0	0	0	0	1	12789	813	29	1		1	PTPN3	9	112153421	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2067153	112153421	29060010	697	19730										
FKBP15	23307	broad.mit.edu	37	chr9	115969571	115969571	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctgtttttggtgttgcctGatttcctgaagatgaacaag	11	6	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:115969571G>C	uc004bgs.2	-	3	293	c.175C>G	c.(175-177)CAG>GAG	p.Q59E	FKBP15_uc010muu.1_Missense_Mutation_p.Q123E|FKBP15_uc011lxd.1_Translation_Start_Site|FKBP15_uc010mut.1_Intron|FKBP15_uc004bgt.2_Missense_Mutation_p.Q59E	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	59					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						GGTGTTGCCTGATTTCCTGAA	0.338													0	0	0	1	0	48	207										C	115969571	G	C	115969571	3	2	65	1	0	0	0	0	1	0	0	0	5905	1299	45	1	3588	1	FKBP15	9	115969571	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3816150	115969571	25243860	698	19731										
ORM1	5004	broad.mit.edu	37	chr9	117087340	117087340	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccctgcagctgacaagccaGagacgaccaaggagcaactg	11	14	0	2	rs143596557		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:117087340G>C	uc004bik.3	+	5	559	c.448G>C	c.(448-450)GAG>CAG	p.E150Q	ORM1_uc011lxo.1_Intron	NM_000607	NP_000598	P02763	A1AG1_HUMAN	orosomucoid 1 precursor	150					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding				0		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	TGACAAGCCAGAGACGACCAA	0.612													0	0	0	1	0	18	61										C	117087340	G	C	117087340	3	2	65	1	0	0	0	0	1	0	0	0	11267	943	33	1	466	1	ORM1	9	117087340	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1117769	117087340	24126091	699	19732										
TNC	3371	broad.mit.edu	37	chr9	117838737	117838737	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctcagcgtggtcccctccaGagatgggggcatacttaatt	11	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:117838737G>A	uc004bjj.3	-	8	3154	c.2792C>T	c.(2791-2793)TCT>TTT	p.S931F	TNC_uc010mvf.2_Missense_Mutation_p.S931F	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	931	Fibronectin type-III 4.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GTCCCCTCCAGAGATGGGGGC	0.507													0	0	0	1	0	64	168										A	117838737	G	A	117838737	3	1	65	1	0	0	0	0	1	0	0	0	16267	942	33	1	3897	1	TNC	9	117838737	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	751397	117838737	23374694	700	19733										
MEGF9	1955	broad.mit.edu	37	chr9	123476050	123476050	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actcacctggaggaggcgaaGagggggcctcggtggcaggt	19	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:123476050G>C	uc004bkj.1	-	1	563	c.563C>G	c.(562-564)TCT>TGT	p.S188C	MEGF9_uc011lyb.1_Missense_Mutation_p.S188C|MEGF9_uc004bkk.3_Missense_Mutation_p.S188C	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	196	Extracellular (Potential).|Pro-rich.					integral to membrane	calcium ion binding				0						AGGAGGCGAAGAGGGGGCCTC	0.682													0	0	0	1	0	6	23										C	123476050	G	C	123476050	3	2	65	1	0	0	0	0	1	0	0	0	9464	942	33	1	1388	1	MEGF9	9	123476050	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5637313	123476050	17737381	701	19734										
GSN	2934	broad.mit.edu	37	chr9	124065295	124065295	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caccgtgaggtccagggcttCgagtcggccaccttcctagg	13	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:124065295C>T	uc004blf.1	+	3	517	c.456C>T	c.(454-456)TTC>TTT	p.F152F	GSN_uc004bld.1_Silent_p.F101F|GSN_uc010mvq.1_Silent_p.F112F|GSN_uc010mvr.1_Silent_p.F112F|GSN_uc010mvu.1_Silent_p.F101F|GSN_uc010mvt.1_Silent_p.F101F|GSN_uc010mvs.1_Silent_p.F101F|GSN_uc004ble.1_Silent_p.F101F|GSN_uc010mvv.1_Silent_p.F101F|GSN_uc011lyh.1_Silent_p.F118F|GSN_uc011lyi.1_Silent_p.F101F|GSN_uc011lyj.1_Silent_p.F125F	NM_000177	NP_000168	P06396	GELS_HUMAN	gelsolin isoform a precursor	152	Actin-severing (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			breast(2)|ovary(1)	3						TCCAGGGCTTCGAGTCGGCCA	0.617													0	0	0	1	0	28	112										T	124065295	C	T	124065295	2	4	65	1	0	0	0	0	0	0	0	1	6825	883	31	1		1	GSN	9	124065295	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	589245	124065295	17148136	702	19735										
DAB2IP	153090	broad.mit.edu	37	chr9	124522678	124522678	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaccaaggaggagatggcatCtgccctggtgcacatcctgc	13	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:124522678C>G	uc004bln.2	+	6	1115	c.1046C>G	c.(1045-1047)TCT>TGT	p.S349C	DAB2IP_uc004blo.2_Missense_Mutation_p.S253C	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	377	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GAGATGGCATCTGCCCTGGTG	0.622													0	0	0	1	0	12	38										G	124522678	C	G	124522678	3	3	65	1	0	0	0	0	1	0	0	0	4219	913	32	1	1068	1	DAB2IP	9	124522678	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	457383	124522678	16690753	703	19736										
GOLGA2	2801	broad.mit.edu	37	chr9	131030767	131030767	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccaggtaacacggtgtcatCagatggttgtagagtagcag	14	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:131030767C>T	uc011maw.1	-	3	257	c.244G>A	c.(244-246)GAT>AAT	p.D82N	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004bul.1_5'UTR|GOLGA2_uc004bum.1_5'UTR	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	82	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						ACGGTGTCATCAGATGGTTGT	0.592													0	0	0	1	0	11	35										T	131030767	C	T	131030767	3	4	65	1	0	0	0	0	1	0	0	0	6552	826	29	1	2860	1	GOLGA2	9	131030767	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6508089	131030767	10182664	704	19737										
ODF2	4957	broad.mit.edu	37	chr9	131258398	131258398	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaaaataaacagctgagtCtgaaggtggatgaactggag	14	4	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:131258398C>G	uc011mbd.1	+	18	2301	c.1990C>G	c.(1990-1992)CTG>GTG	p.L664V	ODF2_uc004bvb.2_Missense_Mutation_p.L640V|ODF2_uc011mbe.1_Missense_Mutation_p.L659V|ODF2_uc004bvc.2_Missense_Mutation_p.L640V|ODF2_uc004bvd.3_Missense_Mutation_p.L664V|ODF2_uc004bvh.2_Missense_Mutation_p.L18V	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	664	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						ACAGCTGAGTCTGAAGGTGGA	0.483													0	0	0	1	0	23	82										G	131258398	C	G	131258398	3	3	65	1	0	0	0	0	1	0	0	0	10827	912	32	1	2174	1	ODF2	9	131258398	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	227631	131258398	9955033	705	19738										
ZER1	10444	broad.mit.edu	37	chr9	131515056	131515056	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttccccagcttctgcacaaaGaggctcagcacctcccgagt	8	16	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:131515056G>A	uc004bwa.1	-	5	1252	c.819C>T	c.(817-819)CTC>CTT	p.L273L		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	273					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TCTGCACAAAGAGGCTCAGCA	0.557													0	0	0	1	0	13	70										A	131515056	G	A	131515056	2	1	65	1	0	0	0	0	0	0	0	1	17622	929	33	1		1	ZER1	9	131515056	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	256658	131515056	9698375	706	19739										
C9orf50	375759	broad.mit.edu	37	chr9	132375791	132375791	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacagggctttgggcaaactCtccagccgttttccgacact	9	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:132375791C>G	uc004byc.3	-	5	1168	c.966G>C	c.(964-966)GAG>GAC	p.E322D	C9orf50_uc004byb.3_RNA	NM_199350	NP_955382	Q5SZB4	CI050_HUMAN	hypothetical protein LOC375759	322										ovary(1)|central_nervous_system(1)	2		Ovarian(14;0.00556)				TGGGCAAACTCTCCAGCCGTT	0.632													0	0	0	1	0	32	84										G	132375791	C	G	132375791	3	3	65	1	0	0	0	0	1	0	0	0	2487	912	32	1	341	1	C9orf50	9	132375791	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	860735	132375791	8837640	707	19740										
TOR1A	1861	broad.mit.edu	37	chr9	132584879	132584879	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttgtacaaggtgatgtttGaagcatgtggaaagtgcaat	12	5	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:132584879G>C	uc004byl.2	-	2	502	c.425C>G	c.(424-426)TCA>TGA	p.S142*	TOR1A_uc004bym.2_RNA|TOR1A_uc004byn.2_Nonsense_Mutation_p.S142*	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	142					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				GGTGATGTTTGAAGCATGTGG	0.463													0	0	0	1	0	14	67										C	132584879	G	C	132584879	4	2	65	1	0	0	0	0	0	1	0	0	16368	1294	45	1	589	1	TOR1A	9	132584879	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	209088	132584879	8628552	708	19741										
LAMC3	10319	broad.mit.edu	37	chr9	133948211	133948211	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctgcatgcagctgccattCtcgcgtctctggtatcccag	9	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:133948211C>T	uc004caa.1	+	19	3504	c.3406C>T	c.(3406-3408)CTC>TTC	p.L1136F		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1136	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		AGCTGCCATTCTCGCGTCTCT	0.453													0	0	0	1	0	5	18										T	133948211	C	T	133948211	3	4	65	1	0	0	0	0	1	0	0	0	8616	913	32	1	3480	1	LAMC3	9	133948211	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1363332	133948211	7265220	709	19742										
GTF3C4	9329	broad.mit.edu	37	chr9	135553634	135553634	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagctggttgacctgactGagatctatggagaacgtctt	11	9	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:135553634G>C	uc010mzv.2	+	2	886	c.628G>C	c.(628-630)GAG>CAG	p.E210Q	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	210					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TGACCTGACTGAGATCTATGG	0.507													0	0	0	1	0	19	66										C	135553634	G	C	135553634	3	2	65	1	0	0	0	0	1	0	0	0	6875	1291	45	1	634	1	GTF3C4	9	135553634	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1605423	135553634	5659797	710	19743										
TSC1	7248	broad.mit.edu	37	chr9	135778026	135778026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctggttgtagaattcctctCggtcatgctgcagctgtctg	11	10	4	1	rs118203683		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:135778026C>T	uc004cca.2	-	18	2591	c.2357G>A	c.(2356-2358)CGA>CAA	p.R786Q	TSC1_uc004ccb.3_Missense_Mutation_p.R785Q|TSC1_uc011mcq.1_Missense_Mutation_p.R735Q|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	786	Potential.				activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GAATTCCTCTCGGTCATGCTG	0.527			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis		OREG0019577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	39	141										T	135778026	C	T	135778026	3	4	65	1	0	0	0	0	1	0	0	0	16602	884	31	1	1161	1	TSC1	9	135778026	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	224392	135778026	5435405	711	19744										
RALGDS	5900	broad.mit.edu	37	chr9	136004577	136004577	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccaaggtgtcgggctttgGagagcggcacgacgggcgac	18	10	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:136004577G>C	uc004ccr.2	-	1	212	c.129C>G	c.(127-129)CTC>CTG	p.L43L	RALGDS_uc011mcv.1_Intron|RALGDS_uc004ccs.2_Intron|RALGDS_uc011mcw.1_Intron	NM_001042368	NP_001035827	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TCGGGCTTTGGAGAGCGGCAC	0.687			T	CIITA	PMBL|Hodgkin Lymphona|								0	0	0	1	0	4	19										C	136004577	G	C	136004577	2	2	65	1	0	0	0	0	0	0	0	1	13016	1189	41	1		1	RALGDS	9	136004577	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	226551	136004577	5208854	712	19745										
MED22	6837	broad.mit.edu	37	chr9	136213407	136213407	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acccccaccttggcggtcttGatgatctcggtgaagttgtc	11	12	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:136213407G>C	uc004cdc.2	-	2	345	c.111C>G	c.(109-111)ATC>ATG	p.I37M	MED22_uc004cdd.2_Missense_Mutation_p.I37M|RPL7A_uc004cde.1_5'Flank|SNORD24_uc010nah.2_5'Flank|RPL7A_uc004cdf.1_5'Flank	NM_133640	NP_598395	Q15528	MED22_HUMAN	mediator complex subunit 22 isoform b	37					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|mediator complex|soluble fraction	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.14e-06)|Epithelial(140;8.2e-06)|all cancers(34;6.94e-05)		TGGCGGTCTTGATGATCTCGG	0.597													0	0	0	1	0	33	80										C	136213407	G	C	136213407	3	2	65	1	0	0	0	0	1	0	0	0	9440	1280	45	1	517	1	MED22	9	136213407	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	208830	136213407	5000024	713	19746										
GLT6D1	360203	broad.mit.edu	37	chr9	138516451	138516451	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccatgatgtagaagatcactCggtagcctgtcatgaagtgc	11	9	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:138516451C>T	uc010nbd.1	-	5	577	c.323G>A	c.(322-324)CGA>CAA	p.R108Q		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	108	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GAAGATCACTCGGTAGCCTGT	0.493													0	0	0	1	0	21	63										T	138516451	C	T	138516451	3	4	65	1	0	0	0	0	1	0	0	0	6468	884	31	1	511	1	GLT6D1	9	138516451	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2303044	138516451	2696980	714	19747										
NOTCH1	4851	broad.mit.edu	37	chr9	139396271	139396271	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcggtgtgggggccatggcaGacatgcgcaggtcagcggca	19	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:139396271G>A	uc004chz.2	-	30	5567	c.5567C>T	c.(5566-5568)TCT>TTT	p.S1856F		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1856	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCCATGGCAGACATGCGCAG	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	1	0	14	47										A	139396271	G	A	139396271	3	1	65	1	0	0	0	0	1	0	0	0	10547	942	33	1	2120	1	NOTCH1	9	139396271	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	879820	139396271	1817160	715	19748										
ABCA2	20	broad.mit.edu	37	chr9	139906347	139906347	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgatggggttgcagccgctGacaaactgcaggtgcttggc	15	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:139906347G>A	uc011mem.1	-	34	5629	c.5481C>T	c.(5479-5481)GTC>GTT	p.V1827V	ABCA2_uc011mel.1_Silent_p.V1828V|ABCA2_uc004ckl.1_Silent_p.V1758V|ABCA2_uc004ckm.1_Silent_p.V1858V	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1827					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGCAGCCGCTGACAAACTGCA	0.627													0	0	0	1	0	8	25										A	139906347	G	A	139906347	2	1	65	1	0	0	0	0	0	0	0	1	32	1277	45	1		1	ABCA2	9	139906347	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	510076	139906347	1307084	716	19749										
GRIN1	2902	broad.mit.edu	37	chr9	140051410	140051410	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggccgtgcacgagctcctcGagaaggagaacatcaccgac	12	13	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:140051410G>C	uc004clk.2	+	6	1219	c.889G>C	c.(889-891)GAG>CAG	p.E297Q	GRIN1_uc004cli.1_5'UTR|GRIN1_uc004clj.1_Missense_Mutation_p.E294Q|GRIN1_uc004cll.2_Missense_Mutation_p.E297Q|GRIN1_uc004clm.2_Missense_Mutation_p.E297Q|GRIN1_uc004cln.2_Missense_Mutation_p.E315Q|GRIN1_uc004clo.2_Missense_Mutation_p.E315Q	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	297	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGAGCTCCTCGAGAAGGAGAA	0.682													0	0	0	1	0	13	26										C	140051410	G	C	140051410	3	2	65	1	0	0	0	0	1	0	0	0	6778	1059	37	1	978	1	GRIN1	9	140051410	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	145063	140051410	1162021	717	19750										
ANAPC2	29882	broad.mit.edu	37	chr9	140075251	140075251	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggcctcaccgctcggggctGaagctgaactggtgcagcag	15	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:140075251G>A	uc004clr.1	-	8	1672	c.1599C>T	c.(1597-1599)TTC>TTT	p.F533F	ANAPC2_uc004clq.1_Silent_p.F389F	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	533					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GCTCGGGGCTGAAGCTGAACT	0.662													0	0	0	1	0	25	67										A	140075251	G	A	140075251	2	1	65	1	0	0	0	0	0	0	0	1	603	1281	45	1		1	ANAPC2	9	140075251	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	23841	140075251	1138180	718	19751										
SLC34A3	142680	broad.mit.edu	37	chr9	140130619	140130619	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcatggagctggccgctgtCgggggtcccctggtggggct	20	11	0	0	rs139559169		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:140130619C>T	uc004cmf.1	+	13	1737	c.1551C>T	c.(1549-1551)GTC>GTT	p.V517V	SLC34A3_uc011met.1_Silent_p.V517V	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	517	Helical; Name=M8; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TGGCCGCTGTCGGGGGTCCCC	0.726											OREG0019630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	7	31										T	140130619	C	T	140130619	2	4	65	1	0	0	0	0	0	0	0	1	14569	871	31	1		1	SLC34A3	9	140130619	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	55368	140130619	1082812	719	19752										
PNPLA7	375775	broad.mit.edu	37	chr9	140437939	140437939	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggtgagaattcttcacgtCaaactccgtgaggtcggcct	11	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr9:140437939C>G	uc004cnf.2	-	5	713	c.376G>C	c.(376-378)GAC>CAC	p.D126H	PNPLA7_uc010ncj.1_Missense_Mutation_p.D151H	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	126					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TTCTTCACGTCAAACTCCGTG	0.597													0	0	0	1	0	43	106										G	140437939	C	G	140437939	3	3	65	1	0	0	0	0	1	0	0	0	12170	826	29	1	3697	1	PNPLA7	9	140437939	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	307320	140437939	775492	720	19753										
LARP4B	23185	broad.mit.edu	37	chr10	860896	860896	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caatactcactcgggtaaatGagctggggagggggatcgct	15	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:860896G>A	uc001ifs.1	-	15	1851	c.1810C>T	c.(1810-1812)CAT>TAT	p.H604Y		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	604							nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						TCGGGTAAATGAGCTGGGGAG	0.532													0	0	0	1	0	20	66										A	860896	G	A	860896	3	1	65	1	0	0	0	0	1	0	0	0	8631	1290	45	1	418	1	LARP4B	10	860896	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		860896	134673851	721	19754										
PITRM1	10531	broad.mit.edu	37	chr10	3206032	3206032	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgagtacgtgtggtcaggaaGaagtctgttctgaaggtgct	15	5	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:3206032G>A	uc010qah.1	-	6	612	c.580C>T	c.(580-582)CTT>TTT	p.L194F	PITRM1_uc001igr.1_Missense_Mutation_p.L226F|PITRM1_uc001igt.1_Missense_Mutation_p.L226F|PITRM1_uc001igu.1_Missense_Mutation_p.L218F|PITRM1_uc010qai.1_Missense_Mutation_p.L197F|PITRM1_uc001igw.1_Missense_Mutation_p.L226F|uc001igx.1_5'Flank			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	194					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						TGGTCAGGAAGAAGTCTGTTC	0.438													0	0	0	1	0	25	70										A	3206032	G	A	3206032	3	1	65	1	0	0	0	0	1	0	0	0	11953	942	33	1	2521	1	PITRM1	10	3206032	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2345136	3206032	132328715	722	19755										
NET1	10276	broad.mit.edu	37	chr10	5498204	5498204	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agatgtgagaatgggaggctCctttcgaggagctttcagta	14	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:5498204C>G	uc001iia.2	+	11	1490	c.1352C>G	c.(1351-1353)TCC>TGC	p.S451C	NET1_uc010qar.1_Missense_Mutation_p.S270C|NET1_uc001iib.2_Missense_Mutation_p.S397C|NET1_uc010qas.1_Missense_Mutation_p.S270C	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	451	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						ATGGGAGGCTCCTTTCGAGGA	0.458													0	0	0	1	0	13	47										G	5498204	C	G	5498204	3	3	65	1	0	0	0	0	1	0	0	0	10338	855	30	1	1491	1	NET1	10	5498204	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2292172	5498204	130036543	723	19756										
C10orf18	54906	broad.mit.edu	37	chr10	5772507	5772507	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaggtgatacctattttatCtacccttaattgtgccctgc	7	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:5772507C>G	uc001iij.2	+	11	1170	c.545C>G	c.(544-546)TCT>TGT	p.S182C	C10orf18_uc001iik.2_5'Flank	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	182										ovary(1)|central_nervous_system(1)	2						CCTATTTTATCTACCCTTAAT	0.333													0	0	0	1	0	15	43										G	5772507	C	G	5772507	3	3	65	1	0	0	0	0	1	0	0	0	1596	913	32	1	575	1	C10orf18	10	5772507	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	274303	5772507	129762240	724	19757										
UPF2	26019	broad.mit.edu	37	chr10	12043687	12043687	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctttaccttgttcatcaaGaagtttctttgtaagatctt	5	7	5	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:12043687G>C	uc001ila.2	-	5	2116	c.1642C>G	c.(1642-1644)CTT>GTT	p.L548V	UPF2_uc001ilb.2_Missense_Mutation_p.L548V|UPF2_uc001ilc.2_Missense_Mutation_p.L548V|UPF2_uc009xiz.1_Missense_Mutation_p.L548V	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	548	Potential.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TGTTCATCAAGAAGTTTCTTT	0.333													0	0	0	1	0	3	26										C	12043687	G	C	12043687	3	2	65	1	0	0	0	0	1	0	0	0	17001	942	33	1	2244	1	UPF2	10	12043687	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6271180	12043687	123491060	725	19758										
BEND7	222389	broad.mit.edu	37	chr10	13494604	13494604	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagaatctgtacccaatctCttgggccaggaagcttatcc	9	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:13494604C>G	uc001imm.2	-	7	1259	c.962G>C	c.(961-963)AGA>ACA	p.R321T	BEND7_uc001iml.2_RNA|BEND7_uc001imn.2_Missense_Mutation_p.R82T|BEND7_uc001imo.3_Missense_Mutation_p.R334T	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	373	BEN.						protein binding			ovary(1)|breast(1)	2						TACCCAATCTCTTGGGCCAGG	0.363													0	0	0	1	0	21	70										G	13494604	C	G	13494604	3	3	65	1	0	0	0	0	1	0	0	0	1403	913	32	1	468	1	BEND7	10	13494604	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1450917	13494604	122040143	726	19759										
VIM	7431	broad.mit.edu	37	chr10	17271570	17271570	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgcgccccagcaccagccGcagcctctacgcctcgtccc	9	22	1	0	rs11545553		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:17271570G>A	uc001iou.2	+	2	562	c.149G>A	c.(148-150)CGC>CAC	p.R50H	uc001iot.1_RNA|VIM_uc001iov.1_Missense_Mutation_p.R50H|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.R50H|VIM_uc001ioy.1_Missense_Mutation_p.R50H|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.R50H|VIM_uc001ipc.1_Missense_Mutation_p.R50H	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	50	Head.			Missing (in Ref. 5; BAB71275).	cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						AGCACCAGCCGCAGCCTCTAC	0.756													0	0	0	1	0	9	22										A	17271570	G	A	17271570	3	1	65	1	0	0	0	0	1	0	0	0	17163	1087	38	2	151	2	VIM	10	17271570	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3776966	17271570	118263177	727	19760										
ANKRD26	22852	broad.mit.edu	37	chr10	27294520	27294520	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtaataaaatcttatctttCagatcatataatttttcttt	2	5	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:27294520C>G	uc001ith.2	-	34	5301	c.5129G>C	c.(5128-5130)TGA>TCA	p.*1710S	ANKRD26_uc001itg.2_Nonstop_Mutation_p.*1397S|ANKRD26_uc009xku.1_Nonstop_Mutation_p.*1711S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1710						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TCTTATCTTTCAGATCATATA	0.279													0	0	0	1	0	17	55										G	27294520	C	G	27294520	4	3	65	1	0	0	0	0	0	0	0	0	654	837	29	1	4	1	ANKRD26	10	27294520	Nonstop_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	10022950	27294520	108240227	728	19761										
YME1L1	10730	broad.mit.edu	37	chr10	27403470	27403470	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttagaaggattcttatttCttgttcgatggcagattggg	11	6	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:27403470C>G	uc001iti.2	-	19	2340	c.2158G>C	c.(2158-2160)GAA>CAA	p.E720Q	YME1L1_uc001itj.2_Missense_Mutation_p.E663Q|YME1L1_uc010qdl.1_Missense_Mutation_p.E630Q|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	720					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						ATTCTTATTTCTTGTTCGATG	0.328													0	0	0	1	0	10	39										G	27403470	C	G	27403470	3	3	65	1	0	0	0	0	1	0	0	0	17484	922	32	1	171	1	YME1L1	10	27403470	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	108950	27403470	108131277	729	19762										
MASTL	84930	broad.mit.edu	37	chr10	27458964	27458964	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaatgccattgagacgaaagGtttcaataaaaaggatctgg	10	5	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:27458964G>A	uc001itm.2	+	8	1715	c.1076G>A	c.(1075-1077)GGT>GAT	p.G359D	MASTL_uc001itl.2_Missense_Mutation_p.G359D|MASTL_uc009xkw.1_Missense_Mutation_p.G359D|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	359	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						GAGACGAAAGGTTTCAATAAA	0.433													0	0	0	1	0	18	73										A	27458964	G	A	27458964	3	1	65	1	0	0	0	0	1	0	0	0	9328	1261	44	2	1106	2	MASTL	10	27458964	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	55494	27458964	108075783	730	19763										
MKX	283078	broad.mit.edu	37	chr10	28032180	28032180	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcctccggtgtctcaggccGaggttgtccttgaggggcgg	17	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:28032180G>C	uc001ity.3	-	2	390	c.165C>G	c.(163-165)CTC>CTG	p.L55L	MKX_uc001itx.3_Silent_p.L55L	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	55					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTCTCAGGCCGAGGTTGTCCT	0.746													0	0	0	1	0	4	22										C	28032180	G	C	28032180	2	2	65	1	0	0	0	0	0	0	0	1	9610	1045	37	1		1	MKX	10	28032180	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	573216	28032180	107502567	731	19764										
SVIL	6840	broad.mit.edu	37	chr10	29754631	29754631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggctgcaaaatccccagagGagctgctgaggatgaacagg	14	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:29754631G>A	uc001iut.1	-	34	6779	c.6026C>T	c.(6025-6027)TCC>TTC	p.S2009F	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.S923F|SVIL_uc001iuu.1_Missense_Mutation_p.S1583F	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2009					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ATCCCCAGAGGAGCTGCTGAG	0.483													0	0	0	1	0	6	44										A	29754631	G	A	29754631	3	1	65	1	0	0	0	0	1	0	0	0	15418	1174	41	1	638	1	SVIL	10	29754631	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1722451	29754631	105780116	732	19765										
EPC1	80314	broad.mit.edu	37	chr10	32575725	32575725	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacatcccctaatcctccatCtttaggactagtccaaggcc	5	16	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:32575725C>T	uc001iwg.1	-	9	1558	c.1288G>A	c.(1288-1290)GAT>AAT	p.D430N	EPC1_uc001iwi.3_Missense_Mutation_p.D380N|EPC1_uc009xlt.2_Missense_Mutation_p.D380N|EPC1_uc001iwh.1_Missense_Mutation_p.D430N	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	430					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)				AATCCTCCATCTTTAGGACTA	0.418													0	0	0	1	0	9	37										T	32575725	C	T	32575725	3	4	65	1	0	0	0	0	1	0	0	0	5160	913	32	1	1250	1	EPC1	10	32575725	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2821094	32575725	102959022	733	19766										
RET	5979	broad.mit.edu	37	chr10	43615571	43615571	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagaaacatcctggtagctGaggggcggaagatgaagatt	14	7	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:43615571G>A	uc001jal.2	+	15	2840	c.2650G>A	c.(2650-2652)GAG>AAG	p.E884K	RET_uc001jak.1_Missense_Mutation_p.E884K|RET_uc010qez.1_Missense_Mutation_p.E630K	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	884	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.E884K(1)		thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCTGGTAGCTGAGGGGCGGAA	0.562		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	1	0	12	35										A	43615571	G	A	43615571	3	1	65	1	0	0	0	0	1	0	0	0	13235	1291	45	1	2708	1	RET	10	43615571	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11039846	43615571	91919176	734	19767										
C10orf128	170371	broad.mit.edu	37	chr10	50374939	50374939	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggcccccaggcgtgcttttCaggtcggaagagtcgtcgtc	14	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:50374939C>G	uc001jhn.3	-	3	239	c.213G>C	c.(211-213)CTG>CTC	p.L71L	C10orf128_uc001jhl.3_RNA|C10orf128_uc001jhm.3_Silent_p.L71L|C10orf128_uc010qgo.1_Silent_p.L71L|C10orf128_uc001jho.3_Silent_p.L71L	NM_001010863	NP_001010863	Q5T292	CJ128_HUMAN	hypothetical protein LOC170371 precursor	71	Cytoplasmic (Potential).					integral to membrane				lung(1)	1						GCGTGCTTTTCAGGTCGGAAG	0.612													0	0	0	1	0	28	80										G	50374939	C	G	50374939	2	3	65	1	0	0	0	0	0	0	0	1	1592	813	29	1		1	C10orf128	10	50374939	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6759368	50374939	85159808	735	19768										
ERCC6	2074	broad.mit.edu	37	chr10	50678885	50678885	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtctgctccaaaggctggttGaatccttctttttagatggc	10	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:50678885G>A	uc001jhs.3	-	18	3275	c.3121C>T	c.(3121-3123)CAA>TAA	p.Q1041*	ERCC6_uc009xod.2_Nonsense_Mutation_p.Q201*|ERCC6_uc010qgr.1_Nonsense_Mutation_p.Q411*|ERCC6_uc001jhr.3_Nonsense_Mutation_p.Q409*	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1041	Nuclear localization signal (Potential).				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						AAGGCTGGTTGAATCCTTCTT	0.393								Direct_reversal_of_damage|NER					0	0	0	1	0	24	89										A	50678885	G	A	50678885	4	1	65	1	0	0	0	0	0	1	0	0	5217	1299	45	1	1376	1	ERCC6	10	50678885	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	303946	50678885	84855862	736	19769										
CHAT	1103	broad.mit.edu	37	chr10	50857645	50857645	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaaatgctccccggaaattCaaggccacttagcctcctcg	9	14	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:50857645C>G	uc001jhz.2	+	10	1627	c.1474C>G	c.(1474-1476)CAA>GAA	p.Q492E	CHAT_uc001jhv.1_Missense_Mutation_p.Q374E|CHAT_uc001jhx.1_Missense_Mutation_p.Q374E|CHAT_uc001jhy.1_Missense_Mutation_p.Q374E|CHAT_uc001jia.2_Missense_Mutation_p.Q374E|CHAT_uc010qgs.1_Missense_Mutation_p.Q374E	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	492					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CCCGGAAATTCAAGGCCACTT	0.617													0	0	0	1	0	22	98										G	50857645	C	G	50857645	3	3	65	1	0	0	0	0	1	0	0	0	3313	827	29	1	1556	1	CHAT	10	50857645	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	178760	50857645	84677102	737	19770										
AGAP6	414189	broad.mit.edu	37	chr10	51768909	51768909	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catctaccatcaaagtcccaGgaaagtggccatccctagcc	7	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:51768909G>T	uc001jix.3	+	8	1422	c.1024G>T	c.(1024-1026)GGA>TGA	p.G342*		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	342					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						CAAAGTCCCAGGAAAGTGGCC	0.463													1	0	7.57603e-17	1	8.02642e-17	35	141										T	51768909	G	T	51768909	4	4	65	1	0	0	0	0	0	1	0	0	372	1001	35	4	1054	4	AGAP6	10	51768909	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	911264	51768909	83765838	738	19771										
AGAP6	414189	broad.mit.edu	37	chr10	51769497	51769497	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttatgtcatctattgtcaatGacctagccaacagcatctgg	7	10	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:51769497G>A	uc001jix.3	+	8	2010	c.1612G>A	c.(1612-1614)GAC>AAC	p.D538N		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	538					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						TATTGTCAATGACCTAGCCAA	0.537													0	0	0	1	0	63	192										A	51769497	G	A	51769497	3	1	65	1	0	0	0	0	1	0	0	0	372	1290	45	1	1642	1	AGAP6	10	51769497	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	588	51769497	83765250	739	19772										
CSTF2T	23283	broad.mit.edu	37	chr10	53459127	53459127	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctggtcttggtattcgcaGaagccatagcccttgggttt	11	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:53459127G>T	uc001jjp.2	-	1	229	c.183C>A	c.(181-183)TTC>TTA	p.F61L	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	61	RRM.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GGTATTCGCAGAAGCCATAGC	0.547													1	0	6.23363e-37	1	6.6668e-37	51	189										T	53459127	G	T	53459127	3	4	65	1	0	0	0	0	1	0	0	0	3985	933	33	3	1671	3	CSTF2T	10	53459127	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1689630	53459127	82075620	740	19773										
ANK3	288	broad.mit.edu	37	chr10	61815494	61815494	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgctggagaagtcctactCatctttttcatactgacagg	8	10	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:61815494C>T	uc001jky.2	-	42	13179	c.12987G>A	c.(12985-12987)ATG>ATA	p.M4329I	ANK3_uc001jkw.2_Missense_Mutation_p.M953I|ANK3_uc009xpa.2_Missense_Mutation_p.M953I|ANK3_uc001jkx.2_Missense_Mutation_p.M997I|ANK3_uc010qih.1_Missense_Mutation_p.M1820I|ANK3_uc001jkz.3_Missense_Mutation_p.M1813I|ANK3_uc001jkv.2_Missense_Mutation_p.M352I	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4329					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AAGTCCTACTCATCTTTTTCA	0.473													0	0	0	1	0	79	216										T	61815494	C	T	61815494	3	4	65	1	0	0	0	0	1	0	0	0	622	826	29	1	154	1	ANK3	10	61815494	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8356367	61815494	73719253	741	19774										
JMJD1C	221037	broad.mit.edu	37	chr10	64952854	64952854	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggaggagtattttgctgctGagactcaggcatgcacagag	14	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:64952854G>A	uc001jmn.2	-	16	6220	c.5920C>T	c.(5920-5922)CAG>TAG	p.Q1974*	JMJD1C_uc001jml.2_Nonsense_Mutation_p.Q1737*|JMJD1C_uc001jmm.2_Nonsense_Mutation_p.Q1686*|JMJD1C_uc010qiq.1_Nonsense_Mutation_p.Q1792*|JMJD1C_uc009xpi.2_Nonsense_Mutation_p.Q1792*|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_5'Flank|JMJD1C_uc009xpk.1_Nonsense_Mutation_p.Q872*	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1974					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTTGCTGCTGAGACTCAGGC	0.393													0	0	0	1	0	19	59										A	64952854	G	A	64952854	4	1	65	1	0	0	0	0	0	1	0	0	7950	1299	45	1	1746	1	JMJD1C	10	64952854	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3137360	64952854	70581893	742	19775										
MYPN	84665	broad.mit.edu	37	chr10	69902716	69902716	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtggtactgtgaaggcaagGagcttgaaaattccccagat	13	7	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:69902716G>T	uc001jnm.3	+	4	1107	c.922G>T	c.(922-924)GAG>TAG	p.E308*	MYPN_uc001jnl.1_Nonsense_Mutation_p.E308*|MYPN_uc001jnn.3_Nonsense_Mutation_p.E33*|MYPN_uc001jno.3_Nonsense_Mutation_p.E308*|MYPN_uc001jnp.1_Nonsense_Mutation_p.E308*|MYPN_uc009xps.2_Nonsense_Mutation_p.E308*|MYPN_uc009xpt.2_Nonsense_Mutation_p.E308*|MYPN_uc010qit.1_Nonsense_Mutation_p.E14*|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	308	Interaction with CARP.|Ig-like 1.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						TGAAGGCAAGGAGCTTGAAAA	0.453													1	0	2.23348e-06	1	2.29586e-06	14	60										T	69902716	G	T	69902716	4	4	65	1	0	0	0	0	0	1	0	0	10098	1175	41	3	928	3	MYPN	10	69902716	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4949862	69902716	65632031	743	19776										
ATOH7	220202	broad.mit.edu	37	chr10	69991290	69991290	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccctgcatgcggcggcgctCgcgcgcgttggccgccaggc	16	18	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:69991290C>T	uc001jnq.2	-	1	566	c.145G>A	c.(145-147)GAG>AAG	p.E49K		NM_145178	NP_660161	Q8N100	ATOH7_HUMAN	atonal homolog 7	49	Basic motif.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						CGGCGGCGCTCGCGCGCGTTG	0.736													0	0	0	1	0	7	22										T	69991290	C	T	69991290	3	4	65	1	0	0	0	0	1	0	0	0	1113	893	31	1	317	1	ATOH7	10	69991290	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	88574	69991290	65543457	744	19777										
HKDC1	80201	broad.mit.edu	37	chr10	71008329	71008329	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagcggaagcagatcgacaGggtgctggctttgttccagc	14	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:71008329G>A	uc001jpf.3	+	10	1548	c.1415G>A	c.(1414-1416)AGG>AAG	p.R472K	HKDC1_uc010qje.1_Missense_Mutation_p.R335K	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	472					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						CAGATCGACAGGGTGCTGGCT	0.652													0	0	0	1	0	23	52										A	71008329	G	A	71008329	3	1	65	1	0	0	0	0	1	0	0	0	7193	1000	35	2	1453	2	HKDC1	10	71008329	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1017039	71008329	64526418	745	19778										
EIF4EBP2	1979	broad.mit.edu	37	chr10	72179690	72179691	+	Frame_Shift_Del	DEL	AG	AG	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaactcgaatcatttatgacAgaaagtttctgttggatcgt							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:72179690_72179691delAG	uc001jrb.2	+	2	463_464	c.166_167delAG	c.(166-168)AGAfs	p.R56fs		NM_004096	NP_004087	Q13542	4EBP2_HUMAN	eukaryotic translation initiation factor 4E	56					negative regulation of translational initiation|translation		eukaryotic initiation factor 4E binding				0						CATTTATGACAGAAAGTTTCTG	0.421																		29	112	---	---								-	72179691	AG	-	72179690	7	5	65	1	0	1	0	1	0	0	0	0	5033	180	7	0	172	0	EIF4EBP2	10	72179690	Frame_Shift_Del	DEL	AG	TCGA-DK-A3WW-01A-22D-A23M-08	1171361	72179690	63355057	746	19779										
CDH23	64072	broad.mit.edu	37	chr10	73437306	73437306	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accctgacgatcattgcccgGgacgggggcggcgaggagac	17	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:73437306G>A	uc001jrx.3	+	15	1985	c.1608G>A	c.(1606-1608)CGG>CGA	p.R536R	CDH23_uc001jry.2_Silent_p.R152R|CDH23_uc001jrz.2_Silent_p.R152R	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	536	Cadherin 5.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TCATTGCCCGGGACGGGGGCG	0.602													0	0	0	1	0	8	18										A	73437306	G	A	73437306	2	1	65	1	0	0	0	0	0	0	0	1	3108	1219	43	2		2	CDH23	10	73437306	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1257616	73437306	62097441	747	19780										
NDST2	8509	broad.mit.edu	37	chr10	75567556	75567556	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggattcacttggtagtcccgGagccccaagtttgagtgtaa	12	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:75567556G>A	uc001jvk.2	-	3	1395	c.591C>T	c.(589-591)CTC>CTT	p.L197L	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Silent_p.L74L|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Silent_p.L74L	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	197	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					GGTAGTCCCGGAGCCCCAAGT	0.577													0	0	0	1	0	17	63										A	75567556	G	A	75567556	2	1	65	1	0	0	0	0	0	0	0	1	10256	1161	41	1		1	NDST2	10	75567556	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2130250	75567556	59967191	748	19781										
ZNF503	84858	broad.mit.edu	37	chr10	77158843	77158843	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggtccgcaagtggctcagCagctcttcggacgtggcgaa	15	11	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:77158843C>T	uc001jxg.2	-	2	1941	c.1605G>A	c.(1603-1605)CTG>CTA	p.L535L	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	535	C2H2-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					AGTGGCTCAGCAGCTCTTCGG	0.652													0	0	0	1	0	17	53										T	77158843	C	T	77158843	2	4	65	1	0	0	0	0	0	0	0	1	17948	697	25	2		2	ZNF503	10	77158843	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1591287	77158843	58375904	749	19782										
MMRN2	79812	broad.mit.edu	37	chr10	88704122	88704122	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acccggtgcacatcattctgGagatctcccagcagatgttc	9	13	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:88704122G>A	uc001kea.2	-	5	679	c.552C>T	c.(550-552)CTC>CTT	p.L184L	MMRN2_uc010qmn.1_Intron|MMRN2_uc009xtb.2_Silent_p.L141L	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	184	Potential.					extracellular space				large_intestine(1)	1						CATCATTCTGGAGATCTCCCA	0.532													0	0	0	1	0	52	136										A	88704122	G	A	88704122	2	1	65	1	0	0	0	0	0	0	0	1	9671	1161	41	1		1	MMRN2	10	88704122	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11545279	88704122	46830625	750	19783										
GLUD1	2746	broad.mit.edu	37	chr10	88822464	88822464	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgtcattcctaaaatgctCatgtaagaagcttcattgat	8	7	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:88822464C>T	uc001keh.2	-	6	967	c.870G>A	c.(868-870)ATG>ATA	p.M290I	GLUD1_uc001keg.2_Missense_Mutation_p.M123I|GLUD1_uc010qmp.1_Missense_Mutation_p.M157I	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	290					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTAAAATGCTCATGTAAGAAG	0.388													0	0	0	1	0	13	27										T	88822464	C	T	88822464	3	4	65	1	0	0	0	0	1	0	0	0	6476	826	29	1	838	1	GLUD1	10	88822464	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	118342	88822464	46712283	751	19784										
GLUD1	2746	broad.mit.edu	37	chr10	88822583	88822583	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accagtaacacaggcgtgtgCattaatatcctgtaagaggg	11	8	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:88822583C>T	uc001keh.2	-	6	848	c.751G>A	c.(751-753)GCA>ACA	p.A251T	GLUD1_uc001keg.2_Missense_Mutation_p.A84T|GLUD1_uc010qmp.1_Missense_Mutation_p.A118T	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	251					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	CAGGCGTGTGCATTAATATCC	0.418													0	0	0	1	0	7	25										T	88822583	C	T	88822583	3	4	65	1	0	0	0	0	1	0	0	0	6476	710	25	2	957	2	GLUD1	10	88822583	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	119	88822583	46712164	752	19785										
PTEN	5728	broad.mit.edu	37	chr10	89725197	89725197	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagagaatgaaccttttgatGaagatcagcatacacaaatt	7	7	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:89725197G>A	uc001kfb.2	+	10	2211	c.1180G>A	c.(1180-1182)GAA>AAA	p.E394K		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	394					activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y27fs*1(2)|p.N212fs*1(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ACCTTTTGATGAAGATCAGCA	0.328		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			0	0	0	1	0	10	19										A	89725197	G	A	89725197	3	1	65	1	0	0	0	0	1	0	0	0	12738	1291	45	1	1214	1	PTEN	10	89725197	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	902614	89725197	45809550	753	19786										
KIF20B	9585	broad.mit.edu	37	chr10	91528126	91528126	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatttcagatgatagaaattCttctgtcaaaaaggaacaaa	6	5	4	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:91528126C>T	uc001kgs.1	+	30	5141	c.5069C>T	c.(5068-5070)TCT>TTT	p.S1690F	KIF20B_uc001kgr.1_Missense_Mutation_p.S1650F|KIF20B_uc001kgt.1_Missense_Mutation_p.S901F|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1690	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						GATAGAAATTCTTCTGTCAAA	0.294													0	0	0	1	0	15	30										T	91528126	C	T	91528126	3	4	65	1	0	0	0	0	1	0	0	0	8287	913	32	1	5063	1	KIF20B	10	91528126	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1802929	91528126	44006621	754	19787										
CC2D2B	387707	broad.mit.edu	37	chr10	97769626	97769626	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtcactcatatataagaaaGaattggcttggatgcattgt	10	5	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:97769626G>C	uc001kll.2	+	3	265	c.66G>C	c.(64-66)AAG>AAC	p.K22N	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_RNA|CC2D2B_uc010qop.1_Missense_Mutation_p.K22N	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	22										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		ATATAAGAAAGAATTGGCTTG	0.338													0	0	0	1	0	11	36										C	97769626	G	C	97769626	3	2	65	1	0	0	0	0	1	0	0	0	2729	933	33	1	72	1	CC2D2B	10	97769626	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6241500	97769626	37765121	755	19788										
DNTT	1791	broad.mit.edu	37	chr10	98087257	98087257	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgaagaccttgtcagctgtGtgaccagggcagaagcagag	14	8	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:98087257G>A	uc001kmf.2	+	7	1077	c.907G>A	c.(907-909)GTG>ATG	p.V303M	DNTT_uc001kmg.2_Missense_Mutation_p.V303M	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	303	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TGTCAGCTGTGTGACCAGGGC	0.517													0	0	0	1	0	73	188										A	98087257	G	A	98087257	3	1	65	1	0	0	0	0	1	0	0	0	4680	1377	48	2	933	2	DNTT	10	98087257	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	317631	98087257	37447490	756	19789										
TLL2	7093	broad.mit.edu	37	chr10	98145844	98145844	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagttcaaacacttcaaactGaagggagatccggtactgag	10	9	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:98145844G>A	uc001kml.1	-	15	2207	c.1981C>T	c.(1981-1983)CAG>TAG	p.Q661*		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	661	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		ACTTCAAACTGAAGGGAGATC	0.522													0	0	0	1	0	23	73										A	98145844	G	A	98145844	4	1	65	1	0	0	0	0	0	1	0	0	15943	1299	45	1	1094	1	TLL2	10	98145844	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	58587	98145844	37388903	757	19790										
C10orf12	26148	broad.mit.edu	37	chr10	98744637	98744637	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgccctccctccaggaaaGaaaaagagaatacaaacaaa	7	11	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:98744637G>C	uc001kmv.2	+	1	3597	c.3490G>C	c.(3490-3492)GAA>CAA	p.E1164Q		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	1164										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CTCCAGGAAAGAAAAAGAGAA	0.493													0	0	0	1	0	23	58										C	98744637	G	C	98744637	3	2	65	1	0	0	0	0	1	0	0	0	1589	943	33	1	3492	1	C10orf12	10	98744637	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	598793	98744637	36790110	758	19791										
RRP12	23223	broad.mit.edu	37	chr10	99123623	99123623	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctactcacattcctgatgatCacatcttccattgggtcagc	6	13	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:99123623C>T	uc001knf.2	-	30	3694	c.3555G>A	c.(3553-3555)GTG>GTA	p.V1185V	RRP12_uc001kne.2_Silent_p.V200V|RRP12_uc009xvl.2_Silent_p.V302V|RRP12_uc009xvm.2_Silent_p.V903V|RRP12_uc010qou.1_Silent_p.V1124V|RRP12_uc009xvn.2_Silent_p.V1085V	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1185						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCCTGATGATCACATCTTCCA	0.542													0	0	0	1	0	44	173										T	99123623	C	T	99123623	2	4	65	1	0	0	0	0	0	0	0	1	13686	813	29	1		1	RRP12	10	99123623	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	378986	99123623	36411124	759	19792										
C10orf28	27291	broad.mit.edu	37	chr10	99994257	99994257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acacatgccctaggagtattCtccagtccaattacaggtat	7	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:99994257C>G	uc001kow.3	+	6	2311	c.2016C>G	c.(2014-2016)TTC>TTG	p.F672L	C10orf28_uc001kox.3_Missense_Mutation_p.F686L|C10orf28_uc001koy.3_Missense_Mutation_p.F672L|C10orf28_uc009xvx.2_Missense_Mutation_p.F672L|C10orf28_uc009xvy.2_Missense_Mutation_p.F78L|C10orf28_uc001koz.3_RNA	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	672							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		TAGGAGTATTCTCCAGTCCAA	0.323													0	0	0	1	0	15	44										G	99994257	C	G	99994257	3	3	65	1	0	0	0	0	1	0	0	0	1601	912	32	1	2026	1	C10orf28	10	99994257	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	870634	99994257	35540490	760	19793										
DNMBP	23268	broad.mit.edu	37	chr10	101639649	101639649	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gttcttgcacatcctttgacGaggtcttgactttgcccatt	8	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:101639649G>T	uc001kqj.2	-	16	4559	c.4467C>A	c.(4465-4467)CTC>CTA	p.L1489L	DNMBP_uc010qpl.1_Silent_p.L425L|DNMBP_uc001kqg.2_Silent_p.L777L|DNMBP_uc001kqh.2_Silent_p.L1121L	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1489					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		ATCCTTTGACGAGGTCTTGAC	0.547													1	0	1.08312e-15	1	1.14393e-15	32	101										T	101639649	G	T	101639649	2	4	65	1	0	0	0	0	0	0	0	1	4674	1045	37	3		3	DNMBP	10	101639649	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1645392	101639649	33895098	761	19794										
FBXW4	6468	broad.mit.edu	37	chr10	103372196	103372196	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catccagcaccccagcccctGggggaaagtcactgcccaag	10	17	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:103372196G>A	uc001kto.2	-	7	1221	c.875C>T	c.(874-876)CCA>CTA	p.P292L		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	292	WD 3.				ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		CCCAGCCCCTGGGGGAAAGTC	0.582													0	0	0	1	0	33	127										A	103372196	G	A	103372196	3	1	65	1	0	0	0	0	1	0	0	0	5767	1348	47	2	375	2	FBXW4	10	103372196	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1732547	103372196	32162551	762	19795										
C10orf76	79591	broad.mit.edu	37	chr10	103607320	103607320	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaactccttgagcaggacttCttggctgagtgtgtggaagg	15	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:103607320C>A	uc009xwy.1	-	26	2137	c.2035G>T	c.(2035-2037)GAA>TAA	p.E679*	C10orf76_uc009xwx.1_RNA	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	679						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		AGCAGGACTTCTTGGCTGAGT	0.592													1	0	1.06801e-11	1	1.11821e-11	25	83										A	103607320	C	A	103607320	4	1	65	1	0	0	0	0	0	1	0	0	1616	922	32	3	38	3	C10orf76	10	103607320	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	235124	103607320	31927427	763	19796										
INA	9118	broad.mit.edu	37	chr10	105037875	105037875	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcaggcggcgcgcagcaccGaggccatccgggccagccgc	16	17	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:105037875G>A	uc001kws.2	+	1	956	c.907G>A	c.(907-909)GAG>AAG	p.E303K	uc001kwr.2_5'Flank|INA_uc009xxj.2_Missense_Mutation_p.E303K	NM_032727	NP_116116	Q16352	AINX_HUMAN	internexin neuronal intermediate filament	303	Coil 2.|Rod.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			ovary(1)|breast(1)	2				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		GCGCAGCACCGAGGCCATCCG	0.657													0	0	0	1	0	17	48										A	105037875	G	A	105037875	3	1	65	1	0	0	0	0	1	0	0	0	7730	1059	37	1	909	1	INA	10	105037875	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1430555	105037875	30496872	764	19797										
SLK	9748	broad.mit.edu	37	chr10	105762646	105762646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacagtgctgaggatacgcaGagtaatgatgggaaagaagt	15	4	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:105762646G>C	uc001kxo.1	+	9	1744	c.1710G>C	c.(1708-1710)CAG>CAC	p.Q570H	SLK_uc001kxp.1_Missense_Mutation_p.Q570H	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	570	Glu-rich.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGGATACGCAGAGTAATGATG	0.443													0	0	0	1	0	11	48										C	105762646	G	C	105762646	3	2	65	1	0	0	0	0	1	0	0	0	14748	933	33	1	1744	1	SLK	10	105762646	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	724771	105762646	29772101	765	19798										
C10orf79	80217	broad.mit.edu	37	chr10	105948061	105948061	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtaggcagtgtgaacatctCcaacctgcttctccctgctt	8	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:105948061C>T	uc001kxw.2	-	13	1770	c.1654G>A	c.(1654-1656)GAG>AAG	p.E552K	C10orf79_uc009xxq.2_5'Flank|C10orf79_uc001kxx.3_Missense_Mutation_p.E553K	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	552											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		GTGAACATCTCCAACCTGCTT	0.438													0	0	0	1	0	18	48										T	105948061	C	T	105948061	3	4	65	1	0	0	0	0	1	0	0	0	1618	864	30	1	3447	1	C10orf79	10	105948061	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	185415	105948061	29586686	766	19799										
SORCS1	114815	broad.mit.edu	37	chr10	108378015	108378015	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgaaggatatgcttccctCcaaggtgatcaaaggctaaa	9	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:108378015C>T	uc001kym.2	-	21	2820	c.2812G>A	c.(2812-2814)GAG>AAG	p.E938K	SORCS1_uc001kyl.2_Missense_Mutation_p.E938K|SORCS1_uc009xxs.2_Missense_Mutation_p.E938K|SORCS1_uc001kyn.1_Missense_Mutation_p.E938K|SORCS1_uc001kyo.2_Missense_Mutation_p.E938K	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	938	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATGCTTCCCTCCAAGGTGATC	0.463													0	0	0	1	0	15	51										T	108378015	C	T	108378015	3	4	65	1	0	0	0	0	1	0	0	0	14930	864	30	1	952	1	SORCS1	10	108378015	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2429954	108378015	27156732	767	19800										
SMC3	9126	broad.mit.edu	37	chr10	112361525	112361525	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actaaagaactggaaaagatGacaaatcggcaaggcatgct	10	7	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:112361525G>A	uc001kze.2	+	24	2901	c.2775G>A	c.(2773-2775)ATG>ATA	p.M925I		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	925					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		TGGAAAAGATGACAAATCGGC	0.378													0	0	0	1	0	24	60										A	112361525	G	A	112361525	3	1	65	1	0	0	0	0	1	0	0	0	14784	1290	45	1	2869	1	SMC3	10	112361525	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3983510	112361525	23173222	768	19801										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118354358	118354358	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgggcgcccaggtggcccaGatgctcgacatcctcttggt	14	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:118354358G>C	uc001lco.1	+	5	465	c.447G>C	c.(445-447)CAG>CAC	p.Q149H	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.Q149H|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	149					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AGGTGGCCCAGATGCTCGACA	0.587													0	0	0	1	0	11	49										C	118354358	G	C	118354358	3	2	65	1	0	0	0	0	1	0	0	0	12150	933	33	1	461	1	PNLIPRP1	10	118354358	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5992833	118354358	17180389	769	19802										
KIAA1598	57698	broad.mit.edu	37	chr10	118704476	118704476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttctttcgaaggtccttctCcagctccaggtttacttgca	7	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:118704476C>T	uc009xyw.2	-	8	1168	c.670G>A	c.(670-672)GAG>AAG	p.E224K	KIAA1598_uc001lcz.3_Missense_Mutation_p.E224K|KIAA1598_uc010qso.1_Missense_Mutation_p.E164K|KIAA1598_uc010qsp.1_Missense_Mutation_p.E224K|KIAA1598_uc010qsq.1_Missense_Mutation_p.E164K|KIAA1598_uc001lcy.3_Missense_Mutation_p.E194K	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	224	Potential.				axon guidance	axon					0				all cancers(201;0.00494)		AGGTCCTTCTCCAGCTCCAGG	0.318													0	0	0	1	0	51	199										T	118704476	C	T	118704476	3	4	65	1	0	0	0	0	1	0	0	0	8246	864	30	1	1265	1	KIAA1598	10	118704476	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	350118	118704476	16830271	770	19803										
PDZD8	118987	broad.mit.edu	37	chr10	119044215	119044215	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctgatgattcccatgtttGacggtcgtccgaactgtcct	9	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:119044215G>C	uc001lde.1	-	5	2228	c.2029C>G	c.(2029-2031)CAA>GAA	p.Q677E		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	677					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TCCCATGTTTGACGGTCGTCC	0.433													0	0	0	1	0	14	63										C	119044215	G	C	119044215	3	2	65	1	0	0	0	0	1	0	0	0	11705	1299	45	1	1439	1	PDZD8	10	119044215	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	339739	119044215	16490532	771	19804										
C10orf88	80007	broad.mit.edu	37	chr10	124697599	124697599	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggttcctaaggtagatgagGattgtagtccaatcatatgc	11	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:124697599G>A	uc001lgw.2	-	5	950	c.725C>T	c.(724-726)TCC>TTC	p.S242F	C10orf88_uc001lgx.2_Missense_Mutation_p.S144F	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	242											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		GGTAGATGAGGATTGTAGTCC	0.403													0	0	0	1	0	32	102										A	124697599	G	A	124697599	3	1	65	1	0	0	0	0	1	0	0	0	1622	1174	41	1	620	1	C10orf88	10	124697599	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5653384	124697599	10837148	772	19805										
ZRANB1	54764	broad.mit.edu	37	chr10	126631753	126631753	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgaagtgaaaatggattttCagaggattgaattggctggt	13	3	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:126631753C>T	uc001lic.2	+	1	1062	c.691C>T	c.(691-693)CAG>TAG	p.Q231*	ZRANB1_uc010qug.1_Nonsense_Mutation_p.Q257*	NM_017580	NP_060050	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	231					positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		AATGGATTTTCAGAGGATTGA	0.433													0	0	0	1	0	22	54										T	126631753	C	T	126631753	4	4	65	1	0	0	0	0	0	1	0	0	18219	827	29	1	693	1	ZRANB1	10	126631753	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1934154	126631753	8902994	773	19806										
MKI67	4288	broad.mit.edu	37	chr10	129904353	129904353	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggagtccccacaaatgtgttGatgtctttctcttcacctac	7	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:129904353G>A	uc001lke.2	-	13	5946	c.5751C>T	c.(5749-5751)ATC>ATT	p.I1917I	MKI67_uc001lkf.2_Silent_p.I1557I|MKI67_uc009yav.1_Silent_p.I1492I|MKI67_uc009yaw.1_Silent_p.I1067I	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1917	16 X 122 AA approximate repeats.|8.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAAATGTGTTGATGTCTTTCT	0.478													0	0	0	1	0	64	200										A	129904353	G	A	129904353	2	1	65	1	0	0	0	0	0	0	0	1	9598	1280	45	1		1	MKI67	10	129904353	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3272600	129904353	5630394	774	19807										
GLRX3	10539	broad.mit.edu	37	chr10	131969878	131969878	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggattcagcaaacaaattCtggaaatactaaatagtact	7	6	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:131969878C>G	uc001lkm.1	+	8	824	c.802C>G	c.(802-804)CTG>GTG	p.L268V	GLRX3_uc001lkn.1_Missense_Mutation_p.L268V|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	268	Glutaredoxin 2.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		CAAACAAATTCTGGAAATACT	0.254													0	0	0	1	0	19	68										G	131969878	C	G	131969878	3	3	65	1	0	0	0	0	1	0	0	0	6461	912	32	1	832	1	GLRX3	10	131969878	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2065525	131969878	3564869	775	19808										
JAKMIP3	282973	broad.mit.edu	37	chr10	133918366	133918366	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggggacaaggcagaggccctCgcggcgctgcaggcggccaa	18	13	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:133918366C>T	uc001lkx.3	+	1	54	c.54C>T	c.(52-54)CTC>CTT	p.L18L		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CAGAGGCCCTCGCGGCGCTGC	0.667													0	0	0	1	0	3	6										T	133918366	C	T	133918366	2	4	65	1	0	0	0	0	0	0	0	1	7942	871	31	1		1	JAKMIP3	10	133918366	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1948488	133918366	1616381	776	19809										
PWWP2B	170394	broad.mit.edu	37	chr10	134219649	134219649	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaaactctcccctttctctGaatttttcaaactgagattt	3	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:134219649G>A	uc001lll.3	+	2	1674	c.1645G>A	c.(1645-1647)GAA>AAA	p.E549K	PWWP2B_uc009ybe.2_Intron	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	549	PWWP.										0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		CCCTTTCTCTGAATTTTTCAA	0.488													0	0	0	1	0	32	84										A	134219649	G	A	134219649	3	1	65	1	0	0	0	0	1	0	0	0	12846	1291	45	1	1651	1	PWWP2B	10	134219649	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	301283	134219649	1315098	777	19810										
KNDC1	85442	broad.mit.edu	37	chr10	134999708	134999708	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccggcctcgtcctggatgccGagcgcaccctcggggagctg	15	16	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr10:134999708G>A	uc001llz.1	+	6	857	c.856G>A	c.(856-858)GAG>AAG	p.E286K	KNDC1_uc001lma.1_Missense_Mutation_p.E221K	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	286					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CCTGGATGCCGAGCGCACCCT	0.701													0	0	0	1	0	5	17										A	134999708	G	A	134999708	3	1	65	1	0	0	0	0	1	0	0	0	8426	1059	37	1	878	1	KNDC1	10	134999708	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	780059	134999708	535039	778	19811										
CDHR5	53841	broad.mit.edu	37	chr11	624652	624652	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagggtcacctcctggccctCcgggacgtggatgtccacca	13	15	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:624652C>T	uc001lqj.2	-	2	271	c.166G>A	c.(166-168)GAG>AAG	p.E56K	CDHR5_uc001lqk.2_Missense_Mutation_p.E56K|CDHR5_uc009ycc.2_5'UTR|CDHR5_uc009ycd.2_Missense_Mutation_p.E56K|CDHR5_uc001lql.2_Missense_Mutation_p.E56K|CDHR5_uc001lqm.2_5'UTR|CDHR5_uc009yce.1_Missense_Mutation_p.E56K|CDHR5_uc001lqn.1_Missense_Mutation_p.E56K	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	56	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TCCTGGCCCTCCGGGACGTGG	0.552													0	0	0	1	0	36	127										T	624652	C	T	624652	3	4	65	1	0	0	0	0	1	0	0	0	3122	864	30	1	2427	1	CDHR5	11	624652	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		624652	134381864	779	19812										
AP2A2	161	broad.mit.edu	37	chr11	1008107	1008107	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtgcgtgtccgacttcacgGaggcgccagtcctcaacatt	11	13	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:1008107G>A	uc001lss.2	+	18	2573	c.2392G>A	c.(2392-2394)GAG>AAG	p.E798K		NM_012305	NP_036437	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2	798					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity				0		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		CGACTTCACGGAGGCGCCAGT	0.657													0	0	0	1	0	9	19										A	1008107	G	A	1008107	3	1	65	1	0	0	0	0	1	0	0	0	740	1175	41	1	2462	1	AP2A2	11	1008107	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	383455	1008107	133998409	780	19813										
MUC2	4583	broad.mit.edu	37	chr11	1088741	1088741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggacaggcccatctatgagGaggatctgaagaagtgtgtc	14	7	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:1088741G>A	uc001lsx.1	+	26	3553	c.3526G>A	c.(3526-3528)GAG>AAG	p.E1176K		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1176						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CATCTATGAGGAGGATCTGAA	0.612													0	0	0	1	0	4	22										A	1088741	G	A	1088741	3	1	65	1	0	0	0	0	1	0	0	0	9975	1175	41	1	3628	1	MUC2	11	1088741	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	80634	1088741	133917775	781	19814										
SLC22A18	5002	broad.mit.edu	37	chr11	2929501	2929501	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcctggattccattgccttCggctacctgcaaaccacctt	8	15	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:2929501C>T	uc001lwx.2	+	3	401	c.183C>T	c.(181-183)TTC>TTT	p.F61F	SLC22A18_uc001lwy.2_Silent_p.F61F|SLC22A18_uc001lwz.2_Silent_p.F61F	NM_183233	NP_899056	Q96BI1	S22AI_HUMAN	tumor suppressing subtransferable candidate 5	61	Helical; (Potential).				excretion|organic cation transport	apical plasma membrane|cytoplasmic part|integral to membrane|nuclear envelope	drug:hydrogen antiporter activity|symporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|ovary(1)	3		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCATTGCCTTCGGCTACCTGC	0.617													0	0	0	1	0	25	48										T	2929501	C	T	2929501	2	4	65	1	0	0	0	0	0	0	0	1	14449	883	31	1		1	SLC22A18	11	2929501	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1840760	2929501	132077015	782	19815										
SLC22A18	5002	broad.mit.edu	37	chr11	2946264	2946264	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catgctgggcctctgcgcctCtgtacaaccactgctccgaa	9	16	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:2946264C>T	uc001lwx.2	+	11	1330	c.1112C>T	c.(1111-1113)TCT>TTT	p.S371F	SLC22A18_uc001lwy.2_Missense_Mutation_p.S371F|SLC22A18_uc001lwz.2_Missense_Mutation_p.S273F	NM_183233	NP_899056	Q96BI1	S22AI_HUMAN	tumor suppressing subtransferable candidate 5	371					excretion|organic cation transport	apical plasma membrane|cytoplasmic part|integral to membrane|nuclear envelope	drug:hydrogen antiporter activity|symporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|ovary(1)	3		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTCTGCGCCTCTGTACAACCA	0.652													0	0	0	1	0	35	103										T	2946264	C	T	2946264	3	4	65	1	0	0	0	0	1	0	0	0	14449	913	32	1	1150	1	SLC22A18	11	2946264	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	16763	2946264	132060252	783	19816										
OR51D1	390038	broad.mit.edu	37	chr11	4661773	4661773	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggcagcactcaaggctttCaacacctgcatctcccacct	7	16	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:4661773C>G	uc010qyk.1	+	1	753	c.753C>G	c.(751-753)TTC>TTG	p.F251L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAAGGCTTTCAACACCTGCA	0.557													0	0	0	1	0	33	94										G	4661773	C	G	4661773	3	3	65	1	0	0	0	0	1	0	0	0	11093	825	29	1	755	1	OR51D1	11	4661773	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1715509	4661773	130344743	784	19817										
OR52A4	390053	broad.mit.edu	37	chr11	5142389	5142389	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taagtgactagctgtcgagtGaatactatagcacgcctcag	10	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:5142389G>A	uc001lzz.1	-	1	420	c.420C>T	c.(418-420)TTC>TTT	p.F140F	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GCTGTCGAGTGAATACTATAG	0.458													0	0	0	1	0	12	39										A	5142389	G	A	5142389	2	1	65	1	0	0	0	0	0	0	0	1	11109	1281	45	1		1	OR52A4	11	5142389	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	480616	5142389	129864127	785	19818										
OR52D1	390066	broad.mit.edu	37	chr11	5510634	5510634	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcagtctttcatcttccatCtcatgatgcccagcacaaag	6	13	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:5510634C>T	uc010qzg.1	+	1	698	c.698C>T	c.(697-699)TCT>TTT	p.S233F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATCTTCCATCTCATGATGCC	0.512													0	0	0	1	0	35	161										T	5510634	C	T	5510634	3	4	65	1	0	0	0	0	1	0	0	0	11114	913	32	1	700	1	OR52D1	11	5510634	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	368245	5510634	129495882	786	19819										
UBQLN3	50613	broad.mit.edu	37	chr11	5530516	5530516	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atggcacggtgctgcctcttGatgaccaggtggacagtgag	15	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:5530516G>A	uc001may.1	-	2	359	c.273C>T	c.(271-273)ATC>ATT	p.I91I	HBG2_uc001mak.1_Intron	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	91	Ubiquitin-like.									ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGCCTCTTGATGACCAGGT	0.567													0	0	0	1	0	21	75										A	5530516	G	A	5530516	2	1	65	1	0	0	0	0	0	0	0	1	16895	1280	45	1		1	UBQLN3	11	5530516	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	19882	5530516	129476000	787	19820										
OR56A3	390083	broad.mit.edu	37	chr11	5968681	5968681	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cactggctgtccctgcccctCagcctccttttcctcttggc	7	19	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:5968681C>T	uc010qzt.1	+	1	105	c.105C>T	c.(103-105)CTC>CTT	p.L35L		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCTGCCCCTCAGCCTCCTTT	0.582													0	0	0	1	0	41	96										T	5968681	C	T	5968681	2	4	65	1	0	0	0	0	0	0	0	1	11134	813	29	1		1	OR56A3	11	5968681	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	438165	5968681	129037835	788	19821										
DCHS1	8642	broad.mit.edu	37	chr11	6661080	6661080	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agttccaggctgggtgccctCaggcagtgaggcattgtaga	15	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:6661080C>T	uc001mem.1	-	2	2175	c.1765G>A	c.(1765-1767)GAG>AAG	p.E589K		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	589	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGTGCCCTCAGGCAGTGAG	0.567													0	0	0	1	0	11	65										T	6661080	C	T	6661080	3	4	65	1	0	0	0	0	1	0	0	0	4287	835	29	1	8211	1	DCHS1	11	6661080	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	692399	6661080	128345436	789	19822										
RBMXL2	27288	broad.mit.edu	37	chr11	7110619	7110619	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggccaccaaaccggcgttcGagagcagccggcggggcccg	16	15	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:7110619G>A	uc001mfc.2	+	1	455	c.268G>A	c.(268-270)GAG>AAG	p.E90K		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	90						nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACCGGCGTTCGAGAGCAGCCG	0.602													0	0	0	1	0	6	22										A	7110619	G	A	7110619	3	1	65	1	0	0	0	0	1	0	0	0	13154	1059	37	1	270	1	RBMXL2	11	7110619	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	449539	7110619	127895897	790	19823										
ASCL3	56676	broad.mit.edu	37	chr11	8959695	8959695	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggtagactagagttgcctCtgttgtccatcatttcctct	8	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:8959695C>T	uc001mhd.1	-	2	74	c.14G>A	c.(13-15)AGA>AAA	p.R5K		NM_020646	NP_065697	Q9NQ33	ASCL3_HUMAN	ASCL3	4					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleolus	DNA binding				0				Epithelial(150;1.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0228)		AGAGTTGCCTCTGTTGTCCAT	0.443													0	0	0	1	0	80	227										T	8959695	C	T	8959695	3	4	65	1	0	0	0	0	1	0	0	0	1035	913	32	1	535	1	ASCL3	11	8959695	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1849076	8959695	126046821	791	19824										
SCUBE2	57758	broad.mit.edu	37	chr11	9111371	9111371	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagcccttgggcacactcatCtacatctgcaaaagagcaca	7	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:9111371C>G	uc001mhh.1	-	2	219	c.139G>C	c.(139-141)GAT>CAT	p.D47H	SCUBE2_uc001mhi.1_Missense_Mutation_p.D47H|SCUBE2_uc001mhj.1_Missense_Mutation_p.D47H	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	47	EGF-like 1; calcium-binding (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GCACACTCATCTACATCTGCA	0.443													0	0	0	1	0	27	106										G	9111371	C	G	9111371	3	3	65	1	0	0	0	0	1	0	0	0	13945	913	32	1	3035	1	SCUBE2	11	9111371	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	151676	9111371	125895145	792	19825										
AMPD3	272	broad.mit.edu	37	chr11	10483090	10483090	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgcggcagtttcccaagctGaacatctctgaagtggatga	11	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:10483090G>A	uc001mio.1	+	2	359	c.24G>A	c.(22-24)CTG>CTA	p.L8L	AMPD3_uc010rbz.1_5'UTR|AMPD3_uc001min.1_Silent_p.L17L|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Silent_p.L8L|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Silent_p.L15L|AMPD3_uc009yfy.2_Silent_p.L8L	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	8					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		TTCCCAAGCTGAACATCTCTG	0.537													0	0	0	1	0	49	166										A	10483090	G	A	10483090	2	1	65	1	0	0	0	0	0	0	0	1	587	1277	45	1		1	AMPD3	11	10483090	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1371719	10483090	124523426	793	19826										
MICAL2	9645	broad.mit.edu	37	chr11	12245000	12245000	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagctggagcactaccctCtcgagagactgggctcggtg	15	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:12245000C>T	uc001mjz.2	+	12	1780	c.1492C>T	c.(1492-1494)CTC>TTC	p.L498F	MICAL2_uc010rch.1_Missense_Mutation_p.L498F|MICAL2_uc001mka.2_Missense_Mutation_p.L498F|MICAL2_uc010rci.1_Missense_Mutation_p.L498F|MICAL2_uc001mkb.2_Missense_Mutation_p.L498F|MICAL2_uc001mkc.2_Missense_Mutation_p.L498F|MICAL2_uc001mkd.2_Missense_Mutation_p.L327F|MICAL2_uc010rcj.1_5'UTR	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	498						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GCACTACCCTCTCGAGAGACT	0.562													0	0	0	1	0	28	121										T	12245000	C	T	12245000	3	4	65	1	0	0	0	0	1	0	0	0	9570	913	32	1	1530	1	MICAL2	11	12245000	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1761910	12245000	122761516	794	19827										
BTBD10	84280	broad.mit.edu	37	chr11	13427306	13427306	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgacattcccgttccccactCtgggcactagctaccatgag	8	15	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:13427306C>G	uc001mkz.2	-	7	1163	c.906G>C	c.(904-906)CAG>CAC	p.Q302H	BTBD10_uc010rcl.1_Missense_Mutation_p.Q310H|BTBD10_uc001mla.2_Missense_Mutation_p.Q286H|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.Q254H|BTBD10_uc010rcn.1_Missense_Mutation_p.Q271H|BTBD10_uc009ygo.2_Missense_Mutation_p.Q254H	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	302						nucleus					0				Epithelial(150;0.0214)		GTTCCCCACTCTGGGCACTAG	0.428													0	0	0	1	0	44	117										G	13427306	C	G	13427306	3	3	65	1	0	0	0	0	1	0	0	0	1538	912	32	1	533	1	BTBD10	11	13427306	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1182306	13427306	121579210	795	19828										
RPS13	6207	broad.mit.edu	37	chr11	17099182	17099182	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcacccgggagcatgcatgcGacccatgatggcggcgatca	13	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:17099182G>A	uc001mmp.2	-	1	39	c.7C>T	c.(7-9)CGC>TGC	p.R3C		NM_001017	NP_001008	P62277	RS13_HUMAN	ribosomal protein S13	3					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome				0						GCATGCATGCGACCCATGATG	0.652													0	0	0	1	0	14	50										A	17099182	G	A	17099182	3	1	65	1	0	0	0	0	1	0	0	0	13623	1058	37	1	472	1	RPS13	11	17099182	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3671876	17099182	117907334	796	19829										
NAV2	89797	broad.mit.edu	37	chr11	20078127	20078127	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtcagccgtcttcacagctCacttcatttctctcttcctt	4	15	7	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:20078127C>T	uc010rdm.1	+	21	5313	c.4952C>T	c.(4951-4953)TCA>TTA	p.S1651L	NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_Intron|NAV2_uc001mpt.2_Intron|NAV2_uc009yhx.2_Intron|NAV2_uc009yhy.1_Intron|NAV2_uc009yhz.2_Intron|NAV2_uc001mpu.2_Intron	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1651	Ser-rich.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CTTCACAGCTCACTTCATTTC	0.408													0	0	0	1	0	9	43										T	20078127	C	T	20078127	3	4	65	1	0	0	0	0	1	0	0	0	10184	841	29	1		1	NAV2	11	20078127	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2978945	20078127	114928389	797	19830										
ANO5	203859	broad.mit.edu	37	chr11	22297645	22297645	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acttccacttttcaggtacaGagattacagatatcctcctg	6	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:22297645G>C	uc001mqi.2	+	21	2737	c.2420G>C	c.(2419-2421)AGA>ACA	p.R807T	ANO5_uc001mqj.2_Missense_Mutation_p.R806T	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	807	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TTCAGGTACAGAGATTACAGA	0.323													0	0	0	1	0	11	29										C	22297645	G	C	22297645	3	2	65	1	0	0	0	0	1	0	0	0	700	942	33	1	2502	1	ANO5	11	22297645	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2219518	22297645	112708871	798	19831										
MUC15	143662	broad.mit.edu	37	chr11	26586972	26586972	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accaagtgaagttttctgaaGacagagcaggtgtagcattg	12	6	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:26586972G>C	uc001mqx.2	-	2	700	c.434C>G	c.(433-435)TCT>TGT	p.S145C	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.S172C|MUC15_uc001mqy.2_Missense_Mutation_p.S172C	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	145	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTTTCTGAAGACAGAGCAGG	0.428													0	0	0	1	0	35	122										C	26586972	G	C	26586972	3	2	65	1	0	0	0	0	1	0	0	0	9972	942	33	1	582	1	MUC15	11	26586972	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4289327	26586972	108419544	799	19832										
ELP4	26610	broad.mit.edu	37	chr11	31648699	31648699	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagctgcttcagtttatccaGaacatcatttatgaggaagg	9	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:31648699G>A	uc001mtb.2	+	6	731	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Silent_p.Q232Q|ELP4_uc010rdz.1_Silent_p.Q233Q	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	232					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					AGTTTATCCAGAACATCATTT	0.318													0	0	0	1	0	14	44										A	31648699	G	A	31648699	2	1	65	1	0	0	0	0	0	0	0	1	5082	933	33	1		1	ELP4	11	31648699	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5061727	31648699	103357817	800	19833										
FBXO3	26273	broad.mit.edu	37	chr11	33772145	33772145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agctaagttctggcagaaacGatgtggaaactgacacagta	11	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:33772145G>A	uc001muz.2	-	8	900	c.872C>T	c.(871-873)TCG>TTG	p.S291L	FBXO3_uc010rej.1_5'UTR|FBXO3_uc001muy.2_Missense_Mutation_p.S178L|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Missense_Mutation_p.S291L|FBXO3_uc001mvb.1_Missense_Mutation_p.S286L|FBXO3_uc010rek.1_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	291	ApaG.				proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		TGGCAGAAACGATGTGGAAAC	0.373													0	0	0	1	0	10	34										A	33772145	G	A	33772145	3	1	65	1	0	0	0	0	1	0	0	0	5739	1059	37	1	568	1	FBXO3	11	33772145	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2123446	33772145	101234371	801	19834										
RAG2	5897	broad.mit.edu	37	chr11	36614675	36614675	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtatcatcttcagcacatttCaacatatagaaatagaatcc	4	9	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:36614675C>G	uc001mwv.3	-	2	1232	c.1044G>C	c.(1042-1044)TTG>TTC	p.L348F	RAG1_uc001mwt.2_RNA|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	348					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				CAGCACATTTCAACATATAGA	0.383									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	1	0	32	93										G	36614675	C	G	36614675	3	3	65	1	0	0	0	0	1	0	0	0	13005	825	29	1	543	1	RAG2	11	36614675	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2842530	36614675	98391841	802	19835										
AMBRA1	55626	broad.mit.edu	37	chr11	46419000	46419000	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caccagtgcaacgtttgtctCtacctgttccgtggttctcc	8	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:46419000C>T	uc010rgu.1	-	18	4257	c.3897G>A	c.(3895-3897)TAG>TAA	p.*1299*	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Silent_p.*1270*|AMBRA1_uc001ncu.1_Silent_p.*1209*|AMBRA1_uc001ncv.2_Silent_p.*1302*|AMBRA1_uc001ncw.2_Silent_p.*1180*|AMBRA1_uc001ncx.2_Silent_p.*1239*	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1299					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		ACGTTTGTCTCTACCTGTTCC	0.592													0	0	0	1	0	31	95										T	46419000	C	T	46419000	2	4	65	1	0	0	0	0	0	0	0	1	565	924	32	1		1	AMBRA1	11	46419000	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	9804325	46419000	88587516	803	19836										
CKAP5	9793	broad.mit.edu	37	chr11	46801788	46801788	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggataggagggcaggcttctCatcctcaaagaacattcgca	11	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:46801788C>T	uc001ndi.1	-	20	2499	c.2389G>A	c.(2389-2391)GAG>AAG	p.E797K	CKAP5_uc009ylg.1_Missense_Mutation_p.E683K|CKAP5_uc001ndj.1_Missense_Mutation_p.E797K	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	797					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						GCAGGCTTCTCATCCTCAAAG	0.443													0	0	0	1	0	12	55										T	46801788	C	T	46801788	3	4	65	1	0	0	0	0	1	0	0	0	3445	835	29	1	3809	1	CKAP5	11	46801788	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	382788	46801788	88204728	804	19837										
LRP4	4038	broad.mit.edu	37	chr11	46907941	46907941	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgacatctgtccagtacaCgtggtcatcccgggagtccc	11	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:46907941C>T	uc001ndn.3	-	17	2505	c.2359G>A	c.(2359-2361)GTG>ATG	p.V787M		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	787	Extracellular (Potential).|LDL-receptor class B 6.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GTCCAGTACACGTGGTCATCC	0.577													0	0	0	1	0	7	19										T	46907941	C	T	46907941	3	4	65	1	0	0	0	0	1	0	0	0	8959	536	19	2	3446	2	LRP4	11	46907941	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	106153	46907941	88098575	805	19838										
C11orf49	79096	broad.mit.edu	37	chr11	47073976	47073976	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggaacacacattctctttCgagaattcagcttcgtccaa	7	11	2	1	rs14051		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:47073976C>T	uc001ndp.2	+	3	293	c.187C>T	c.(187-189)CGA>TGA	p.R63*	C11orf49_uc001nds.2_Nonsense_Mutation_p.R63*|C11orf49_uc001ndq.2_Nonsense_Mutation_p.R63*|C11orf49_uc001ndr.2_Nonsense_Mutation_p.R63*|C11orf49_uc010rgx.1_5'UTR|C11orf49_uc010rgy.1_Nonsense_Mutation_p.R54*|C11orf49_uc010rgz.1_Intron	NM_024113	NP_077018	Q9H6J7	CK049_HUMAN	hypothetical protein LOC79096 isoform 3	63											0						CATTCTCTTTCGAGAATTCAG	0.453													0	0	0	1	0	50	134										T	47073976	C	T	47073976	4	4	65	1	0	0	0	0	0	1	0	0	1645	876	31	1	197	1	C11orf49	11	47073976	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	166035	47073976	87932540	806	19839										
DDB2	1643	broad.mit.edu	37	chr11	47259519	47259519	+	Silent	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagggaagatgatgtgtcaGctctatgacccagaatcttc							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:47259519G>A	uc001neb.2	+	8	1350	c.1155G>A	c.(1153-1155)CAG>CAA	p.Q385Q	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Silent_p.Q321Q|DDB2_uc001ned.2_RNA|DDB2_uc001nee.2_Silent_p.Q196Q|DDB2_uc001nef.2_Silent_p.Q182Q|DDB2_uc001neg.2_Silent_p.Q244Q|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	385					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TGATGTGTCAGCTCTATGACC	0.463			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	18	70										A	47259519	G	A	47259519	2	1	65	1	0	0	0	0	0	0	0	1	4324	962	34	2		2	DDB2	11	47259519	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	185543	47259519	87746997	807	19840	98	2								
DDB2	1643	broad.mit.edu	37	chr11	47259526	47259526	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agatgatgtgtcagctctatGacccagaatcttctggcatc							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:47259526G>A	uc001neb.2	+	8	1357	c.1162G>A	c.(1162-1164)GAC>AAC	p.D388N	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.D324N|DDB2_uc001ned.2_RNA|DDB2_uc001nee.2_Missense_Mutation_p.D199N|DDB2_uc001nef.2_Missense_Mutation_p.D185N|DDB2_uc001neg.2_Missense_Mutation_p.D247N|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	388					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TCAGCTCTATGACCCAGAATC	0.463			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	17	63										A	47259526	G	A	47259526	3	1	65	1	0	0	0	0	1	0	0	0	4324	1290	45	1	1192	1	DDB2	11	47259526	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7	47259526	87746990	808	19841	98	2								
MYBPC3	4607	broad.mit.edu	37	chr11	47372904	47372904	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcgtatgccgtgtgccctCtgtggccaggccgtacttgt	13	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:47372904C>T	uc001nfa.3	-	2	233	c.178G>A	c.(178-180)GAG>AAG	p.E60K		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	60					cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		CGTGTGCCCTCTGTGGCCAGG	0.632													0	0	0	1	0	3	21										T	47372904	C	T	47372904	3	4	65	1	0	0	0	0	1	0	0	0	10013	922	32	1	3771	1	MYBPC3	11	47372904	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	113378	47372904	87633612	809	19842										
PTPRJ	5795	broad.mit.edu	37	chr11	48161324	48161324	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacacctgcactactggcatCacaggtgggctacaaggcag	11	12	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:48161324C>T	uc001ngp.3	+	11	2794	c.2439C>T	c.(2437-2439)ATC>ATT	p.I813I	PTPRJ_uc010rhr.1_Silent_p.I258I	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	813	Extracellular (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						CTACTGGCATCACAGGTGGGC	0.542													0	0	0	1	0	10	27										T	48161324	C	T	48161324	2	4	65	1	0	0	0	0	0	0	0	1	12804	816	29	1		1	PTPRJ	11	48161324	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	788420	48161324	86845192	810	19843										
TRIM48	79097	broad.mit.edu	37	chr11	55032749	55032749	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctctcaggagcaccggtatCacagacactgtcccgctgag	11	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:55032749C>T	uc010rid.1	+	2	504	c.418C>T	c.(418-420)CAC>TAC	p.H140Y		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	124	B box-type.					intracellular	zinc ion binding				0						GCACCGGTATCACAGACACTG	0.507													0	0	0	1	0	25	34										T	55032749	C	T	55032749	3	4	65	1	0	0	0	0	1	0	0	0	16520	826	29	1	424	1	TRIM48	11	55032749	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6871425	55032749	79973767	811	19844										
OR4C15	81309	broad.mit.edu	37	chr11	55321997	55321997	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctcctgggactttcacagaAtccaaatgttcaggaaatag	8	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:55321997A>T	uc010rig.1	+	1	215	c.215A>T	c.(214-216)AAT>ATT	p.N72I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTTCACAGAATCCAAATGTT	0.398										HNSCC(20;0.049)			0	0	0	1	0	35	96										T	55321997	A	T	55321997	3	4	65	1	0	0	0	0	1	0	0	0	11048	101	4	5	217	5	OR4C15	11	55321997	Missense_Mutation	SNP	A	TCGA-DK-A3WW-01A-22D-A23M-08	289248	55321997	79684519	812	19845										
OR4C16	219428	broad.mit.edu	37	chr11	55340229	55340229	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggccatttgtgcagtgagttAtgtcatgctaatattctcct	9	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:55340229A>C	uc010rih.1	+	1	626	c.626A>C	c.(625-627)TAT>TCT	p.Y209S		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GCAGTGAGTTATGTCATGCTA	0.433													0	0	0	1	0	17	45										C	55340229	A	C	55340229	3	2	65	1	0	0	0	0	1	0	0	0	11049	449	16	5	628	5	OR4C16	11	55340229	Missense_Mutation	SNP	A	TCGA-DK-A3WW-01A-22D-A23M-08	18232	55340229	79666287	813	19846										
OR8I2	120586	broad.mit.edu	37	chr11	55861684	55861684	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagatgtgaaaaatgctcttCtgagagtcatacatagaaaa	8	5	3	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:55861684C>G	uc010rix.1	+	1	901	c.901C>G	c.(901-903)CTG>GTG	p.L301V		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					AAATGCTCTTCTGAGAGTCAT	0.388													0	0	0	1	0	7	21										G	55861684	C	G	55861684	3	3	65	1	0	0	0	0	1	0	0	0	11240	912	32	1	903	1	OR8I2	11	55861684	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	521455	55861684	79144832	814	19847										
OR8H3	390152	broad.mit.edu	37	chr11	55890712	55890712	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attcccatgctgaatccactCatttatagtcttagaaacag	5	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:55890712C>G	uc001nii.1	+	1	864	c.864C>G	c.(862-864)CTC>CTG	p.L288L		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TGAATCCACTCATTTATAGTC	0.363													0	0	0	1	0	17	54										G	55890712	C	G	55890712	2	3	65	1	0	0	0	0	0	0	0	1	11239	813	29	1		1	OR8H3	11	55890712	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	29028	55890712	79115804	815	19848										
OR8K3	219473	broad.mit.edu	37	chr11	56086160	56086160	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacgacctctatgtggccatCtgtaaccctctgctatacac	6	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:56086160C>T	uc010rjf.1	+	1	378	c.378C>T	c.(376-378)ATC>ATT	p.I126I		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ATGTGGCCATCTGTAACCCTC	0.413													0	0	0	1	0	20	62										T	56086160	C	T	56086160	2	4	65	1	0	0	0	0	0	0	0	1	11244	903	32	1		1	OR8K3	11	56086160	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	195448	56086160	78920356	816	19849										
APLNR	187	broad.mit.edu	37	chr11	57004286	57004286	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggctagcaatgaagatatCagctgagcgcctcttctccc	9	13	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:57004286C>T	uc001njo.2	-	1	642	c.193G>A	c.(193-195)GAT>AAT	p.D65N	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	65	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						ATGAAGATATCAGCTGAGCGC	0.612													0	0	0	1	0	20	59										T	57004286	C	T	57004286	3	4	65	1	0	0	0	0	1	0	0	0	777	826	29	1	953	1	APLNR	11	57004286	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	918126	57004286	78002230	817	19850										
SMTNL1	219537	broad.mit.edu	37	chr11	57310770	57310770	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggctgaacccaaggagcccGatgggaaagaggaggccaaa	15	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:57310770G>A	uc009ymh.1	+	2	709	c.709G>A	c.(709-711)GAT>AAT	p.D237N		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	219										ovary(1)	1						CAAGGAGCCCGATGGGAAAGA	0.557													0	0	0	1	0	23	45										A	57310770	G	A	57310770	3	1	65	1	0	0	0	0	1	0	0	0	14815	1058	37	1	715	1	SMTNL1	11	57310770	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	306484	57310770	77695746	818	19851										
SMTNL1	219537	broad.mit.edu	37	chr11	57310839	57310839	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagaggaggcggaggatgcaGaggaggcagtgagtgaggca	21	4	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:57310839G>A	uc009ymh.1	+	2	778	c.778G>A	c.(778-780)GAG>AAG	p.E260K		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	242										ovary(1)	1						GGAGGATGCAGAGGAGGCAGT	0.567													0	0	0	1	0	13	55										A	57310839	G	A	57310839	3	1	65	1	0	0	0	0	1	0	0	0	14815	943	33	1	784	1	SMTNL1	11	57310839	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	69	57310839	77695677	819	19852										
SERPING1	710	broad.mit.edu	37	chr11	57373936	57373936	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaatggaaccctttcacttCaaaaactcagttataaaagt	5	8	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:57373936C>T	uc001nkp.1	+	6	1136	c.945C>T	c.(943-945)TTC>TTT	p.F315F	SERPING1_uc001nkq.1_Silent_p.F315F|SERPING1_uc010rju.1_Silent_p.F263F|SERPING1_uc010rjv.1_Silent_p.F320F|SERPING1_uc001nkr.1_Silent_p.F315F|SERPING1_uc009ymi.1_Silent_p.F324F|SERPING1_uc009ymj.1_Silent_p.F315F|SERPING1_uc001nks.1_Silent_p.F6F	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	315				HFKNSVI -> QLQKLSY (in Ref. 19; AA sequence).	blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						CCTTTCACTTCAAAAACTCAG	0.423									Hereditary_Angioedema				0	0	0	1	0	29	97										T	57373936	C	T	57373936	2	4	65	1	0	0	0	0	0	0	0	1	14116	825	29	1		1	SERPING1	11	57373936	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	63097	57373936	77632580	820	19853										
GLYAT	10249	broad.mit.edu	37	chr11	58477493	58477493	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagcacacaggggtcccctCaggccccaggagacagcagg	13	16	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:58477493C>T	uc001nnb.2	-	6	792	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	213					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	GGGGTCCCCTCAGGCCCCAGG	0.537													0	0	0	1	0	19	82										T	58477493	C	T	58477493	3	4	65	1	0	0	0	0	1	0	0	0	6479	835	29	1	257	1	GLYAT	11	58477493	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1103557	58477493	76529023	821	19854										
TMEM132A	54972	broad.mit.edu	37	chr11	60699265	60699265	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacgtggcagctggagtaccCaggccaggcccctgaagcag	14	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:60699265C>G	uc001nqj.2	+	6	1314	c.1121C>G	c.(1120-1122)CCA>CGA	p.P374R	TMEM132A_uc001nqi.2_Missense_Mutation_p.P375R|TMEM132A_uc001nqk.2_Missense_Mutation_p.P387R|TMEM132A_uc001nql.1_Missense_Mutation_p.P387R|TMEM132A_uc001nqm.2_5'Flank	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	374	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CTGGAGTACCCAGGCCAGGCC	0.577													0	0	0	1	0	36	114										G	60699265	C	G	60699265	3	3	65	1	0	0	0	0	1	0	0	0	16042	594	21	4	1146	4	TMEM132A	11	60699265	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2221772	60699265	74307251	822	19855										
VWCE	220001	broad.mit.edu	37	chr11	61058812	61058812	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagatgccactcccacagccGaaggagcagagggctgagag	14	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:61058812G>A	uc001nra.2	-	3	498	c.219C>T	c.(217-219)TTC>TTT	p.F73F	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	73	EGF-like 1.					extracellular region	calcium ion binding			ovary(1)	1						TCCCACAGCCGAAGGAGCAGA	0.642													0	0	0	1	0	3	26										A	61058812	G	A	61058812	2	1	65	1	0	0	0	0	0	0	0	1	17242	1049	37	1		1	VWCE	11	61058812	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	359547	61058812	73947704	823	19856										
RAB3IL1	5866	broad.mit.edu	37	chr11	61672247	61672247	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctgcattgtgaagtccagGcaggggcccacgtcctctcg	12	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:61672247G>A	uc001nso.2	-	6	923	c.765C>T	c.(763-765)TGC>TGT	p.C255C	RAB3IL1_uc001nsp.2_Silent_p.C229C	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	255							protein binding			skin(2)|central_nervous_system(1)	3						TGAAGTCCAGGCAGGGGCCCA	0.662													0	0	0	1	0	3	23										A	61672247	G	A	61672247	2	1	65	1	0	0	0	0	0	0	0	1	12937	1195	42	2		2	RAB3IL1	11	61672247	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	613435	61672247	73334269	824	19857										
AHNAK	79026	broad.mit.edu	37	chr11	62293224	62293224	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcatcttcaggtgccagtCtggaccctgaacattaacat	10	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62293224C>G	uc001ntl.2	-	5	8965	c.8665G>C	c.(8665-8667)GAC>CAC	p.D2889H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2889					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGGTGCCAGTCTGGACCCTGA	0.517													0	0	0	1	0	82	258										G	62293224	C	G	62293224	3	3	65	1	0	0	0	0	1	0	0	0	414	913	32	1	9127	1	AHNAK	11	62293224	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	620977	62293224	72713292	825	19858										
AHNAK	79026	broad.mit.edu	37	chr11	62293417	62293417	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttaaaatgcatctctggcatCttaaactttggacttttcca	5	9	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62293417C>G	uc001ntl.2	-	5	8772	c.8472G>C	c.(8470-8472)AAG>AAC	p.K2824N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2824					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCTCTGGCATCTTAAACTTTG	0.428													0	0	0	1	0	37	128										G	62293417	C	G	62293417	3	3	65	1	0	0	0	0	1	0	0	0	414	912	32	1	9320	1	AHNAK	11	62293417	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	193	62293417	72713099	826	19859										
AHNAK	79026	broad.mit.edu	37	chr11	62294428	62294428	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actttggggcccctgatgttCatatctggtacttcaagttt	9	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62294428C>T	uc001ntl.2	-	5	7761	c.7461G>A	c.(7459-7461)ATG>ATA	p.M2487I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2487					nervous system development	nucleus	protein binding	p.M2487V(1)		ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCCTGATGTTCATATCTGGTA	0.478													0	0	0	1	0	75	165										T	62294428	C	T	62294428	3	4	65	1	0	0	0	0	1	0	0	0	414	826	29	1	10331	1	AHNAK	11	62294428	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1011	62294428	72712088	827	19860										
GANAB	23193	broad.mit.edu	37	chr11	62397394	62397394	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgaacacagatggttcgttCatgtcattccagacaaagag	9	8	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62397394C>T	uc001nub.2	-	14	1662	c.1629G>A	c.(1627-1629)ATG>ATA	p.M543I	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Missense_Mutation_p.M565I|GANAB_uc001nuc.2_Missense_Mutation_p.M446I|GANAB_uc010rma.1_Missense_Mutation_p.M451I|GANAB_uc010rmb.1_Missense_Mutation_p.M429I	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	543					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						ATGGTTCGTTCATGTCATTCC	0.537													0	0	0	1	0	20	85										T	62397394	C	T	62397394	3	4	65	1	0	0	0	0	1	0	0	0	6233	826	29	1	1249	1	GANAB	11	62397394	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	102966	62397394	72609122	828	19861										
INTS5	80789	broad.mit.edu	37	chr11	62416061	62416061	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccaagagctggtgctgccaGaggaagcgcttccgttccaa	12	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62416061G>A	uc001nud.2	-	2	1544	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	497					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GGTGCTGCCAGAGGAAGCGCT	0.602													0	0	0	1	0	52	167										A	62416061	G	A	62416061	2	1	65	1	0	0	0	0	0	0	0	1	7781	929	33	1		1	INTS5	11	62416061	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	18667	62416061	72590455	829	19862										
C11orf83	790955	broad.mit.edu	37	chr11	62439326	62439326	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgggagagcggcggaagcagGaaatgctaaaggtagaagca	17	6	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62439326G>A	uc001nui.3	+	1	201	c.109G>A	c.(109-111)GAA>AAA	p.E37K	C11orf48_uc001nue.2_5'Flank|C11orf48_uc001nuf.2_5'Flank|C11orf48_uc010rmd.1_5'Flank	NM_001085372	NP_001078841	Q6UW78	CK083_HUMAN	hypothetical protein LOC790955 precursor	37						extracellular region					0						GCGGAAGCAGGAAATGCTAAA	0.632													0	0	0	1	0	21	62										A	62439326	G	A	62439326	3	1	65	1	0	0	0	0	1	0	0	0	1666	1175	41	1	111	1	C11orf83	11	62439326	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	23265	62439326	72567190	830	19863										
HNRNPUL2	221092	broad.mit.edu	37	chr11	62483065	62483065	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctcccctgtatcgatcataGaaattacggtaaccctgaga	7	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62483065G>A	uc001nuw.2	-	13	2263	c.2070C>T	c.(2068-2070)TTC>TTT	p.F690F	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	690	Tyr-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0						ATCGATCATAGAAATTACGGT	0.423													0	0	0	1	0	27	95										A	62483065	G	A	62483065	2	1	65	1	0	0	0	0	0	0	0	1	7275	933	33	1		1	HNRNPUL2	11	62483065	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	43739	62483065	72523451	831	19864										
NXF1	10482	broad.mit.edu	37	chr11	62563952	62563952	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgggcagggttctgaggaatGaaaggaatgctcagggaaca	16	6	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62563952G>A	uc001nvf.1	-	14	1402	c.1266C>T	c.(1264-1266)TTC>TTT	p.F422F	NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Silent_p.F465F	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	422	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TCTGAGGAATGAAAGGAATGC	0.547													0	0	0	1	0	31	135										A	62563952	G	A	62563952	2	1	65	1	0	0	0	0	0	0	0	1	10782	1281	45	1		1	NXF1	11	62563952	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	80887	62563952	72442564	832	19865										
SLC22A25	387601	broad.mit.edu	37	chr11	62985102	62985102	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatgtagcagccccagccaaGaagcgcagggagcagtatac	12	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:62985102G>T	uc001nwr.1	-	3	612	c.612C>A	c.(610-612)TTC>TTA	p.F204L	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_Intron|SLC22A25_uc001nwt.1_Missense_Mutation_p.F204L	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	204	Extracellular (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						CCCCAGCCAAGAAGCGCAGGG	0.473													1	0	1.58986e-06	1	1.63725e-06	10	46										T	62985102	G	T	62985102	3	4	65	1	0	0	0	0	1	0	0	0	14454	933	33	3	1059	3	SLC22A25	11	62985102	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	421150	62985102	72021414	833	19866										
RTN3	10313	broad.mit.edu	37	chr11	63520033	63520033	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagctttccataattacatGaatgctgccatggtgcacat	8	9	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:63520033G>A	uc001nxq.2	+	5	2980	c.2793G>A	c.(2791-2793)ATG>ATA	p.M931I	RTN3_uc001nxo.2_Missense_Mutation_p.M135I|RTN3_uc001nxm.2_Missense_Mutation_p.M154I|RTN3_uc001nxn.2_Missense_Mutation_p.M912I|RTN3_uc001nxp.2_Missense_Mutation_p.M135I|RTN3_uc009yov.2_Missense_Mutation_p.M819I|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	931	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						ATAATTACATGAATGCTGCCA	0.423													0	0	0	1	0	39	117										A	63520033	G	A	63520033	3	1	65	1	0	0	0	0	1	0	0	0	13727	1290	45	1	2811	1	RTN3	11	63520033	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	534931	63520033	71486483	834	19867										
FERMT3	83706	broad.mit.edu	37	chr11	63978565	63978565	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtccctgctccgggctcctGagaagaaggagaagaagaag	14	9	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:63978565G>A	uc001nyl.2	+	4	585	c.436G>A	c.(436-438)GAG>AAG	p.E146K	FERMT3_uc001nym.2_Missense_Mutation_p.E146K	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	146					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						CCGGGCTCCTGagaagaagga	0.552													0	0	0	1	0	5	12										A	63978565	G	A	63978565	3	1	65	1	0	0	0	0	1	0	0	0	5819	1291	45	1	446	1	FERMT3	11	63978565	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	458532	63978565	71027951	835	19868										
PYGM	5837	broad.mit.edu	37	chr11	64514790	64514790	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagctgctcaatgacctgccGaagctcaggaatgcgatcgt	11	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:64514790G>A	uc001oax.3	-	18	3035	c.2218C>T	c.(2218-2220)CGG>TGG	p.R740W	RASGRP2_uc009ypv.2_5'Flank|RASGRP2_uc009ypw.2_5'Flank|RASGRP2_uc001oaw.1_5'Flank|PYGM_uc001oay.3_Missense_Mutation_p.R652W	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	740					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	ATGACCTGCCGAAGCTCAGGA	0.567													0	0	0	1	0	30	63										A	64514790	G	A	64514790	3	1	65	1	0	0	0	0	1	0	0	0	12862	1057	37	1	322	1	PYGM	11	64514790	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	536225	64514790	70491726	836	19869										
NAALADL1	10004	broad.mit.edu	37	chr11	64821987	64821987	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taggaattgggggaaatccgGagacattggcaaggtccacg	15	7	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:64821987G>A	uc001ocn.2	-	5	843	c.827C>T	c.(826-828)TCC>TTC	p.S276F	NAALADL1_uc010rnw.1_5'UTR	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	276	NAALADase.|Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						GGGAAATCCGGAGACATTGGC	0.597													0	0	0	1	0	10	35										A	64821987	G	A	64821987	3	1	65	1	0	0	0	0	1	0	0	0	10129	1174	41	1	1451	1	NAALADL1	11	64821987	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	307197	64821987	70184529	837	19870										
SLC22A20	440044	broad.mit.edu	37	chr11	64985056	64985056	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctacctgcagctggcagcttCgggggccgccacagcgtatt	13	14	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:64985056C>T	uc010roc.1	+	3	533	c.530C>T	c.(529-531)TCG>TTG	p.S177L	SLC22A20_uc010rob.1_Missense_Mutation_p.S177L	NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	177	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						CTGGCAGCTTCGGGGGCCGCC	0.602													0	0	0	1	0	13	27										T	64985056	C	T	64985056	3	4	65	1	0	0	0	0	1	0	0	0	14451	893	31	1	546	1	SLC22A20	11	64985056	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	163069	64985056	70021460	838	19871										
SNX32	254122	broad.mit.edu	37	chr11	65618826	65618826	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agacgattatatccctatctCagctgcgctgagcagtctgg	10	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:65618826C>T	uc001ofr.2	+	8	864	c.737C>T	c.(736-738)TCA>TTA	p.S246L		NM_152760	NP_689973	Q86XE0	SNX32_HUMAN	sorting nexin 6B	246					cell communication|protein transport		phosphatidylinositol binding				0				READ - Rectum adenocarcinoma(159;0.171)		ATCCCTATCTCAGCTGCGCTG	0.562											OREG0021087	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	14	40										T	65618826	C	T	65618826	3	4	65	1	0	0	0	0	1	0	0	0	14902	838	29	1	767	1	SNX32	11	65618826	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	633770	65618826	69387690	839	19872										
CATSPER1	117144	broad.mit.edu	37	chr11	65793777	65793777	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgtgggggtgatgagtgaGagcgaaagaacctatctgcg	18	5	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:65793777G>C	uc001ogt.2	-	1	212	c.74C>G	c.(73-75)TCT>TGT	p.S25C		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	25	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						TGATGAGTGAGAGCGAAAGAA	0.542													0	0	0	1	0	33	132										C	65793777	G	C	65793777	3	2	65	1	0	0	0	0	1	0	0	0	2687	942	33	1	2316	1	CATSPER1	11	65793777	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	174951	65793777	69212739	840	19873										
LRFN4	78999	broad.mit.edu	37	chr11	66627266	66627266	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttctccacgctgccggcctCgcccctgtgccacgccctgc	9	21	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:66627266C>G	uc001ojr.2	+	2	1848	c.1508C>G	c.(1507-1509)TCG>TGG	p.S503W	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	503	Extracellular (Potential).					integral to membrane					0						CTGCCGGCCTCGCCCCTGTGC	0.701													0	0	0	1	0	4	26										G	66627266	C	G	66627266	3	3	65	1	0	0	0	0	1	0	0	0	8940	893	31	1	1514	1	LRFN4	11	66627266	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	833489	66627266	68379250	841	19874										
NDUFV1	4723	broad.mit.edu	37	chr11	67379873	67379873	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccactttcggccggagctcGaggagcggatgcagcggttt	16	11	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:67379873G>A	uc001omj.2	+	10	1492	c.1339G>A	c.(1339-1341)GAG>AAG	p.E447K	NDUFV1_uc010rpv.1_Missense_Mutation_p.E346K|NDUFV1_uc001oml.2_Missense_Mutation_p.E440K|NDUFV1_uc001omk.3_Missense_Mutation_p.E438K|NDUFV1_uc010rpw.1_Missense_Mutation_p.E156K	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	447					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	GCCGGAGCTCGAGGAGCGGAT	0.632													0	0	0	1	0	12	47										A	67379873	G	A	67379873	3	1	65	1	0	0	0	0	1	0	0	0	10299	1059	37	1	1377	1	NDUFV1	11	67379873	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	752607	67379873	67626643	842	19875										
TBX10	347853	broad.mit.edu	37	chr11	67402490	67402490	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctgccttggtgacgatcatCtcagtgcccagctggttgaa	11	12	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:67402490C>T	uc001omp.2	-	2	340	c.252G>A	c.(250-252)GAG>GAA	p.E84E		NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	84	T-box.				anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TGACGATCATCTCAGTGCCCA	0.647													0	0	0	1	0	26	45										T	67402490	C	T	67402490	2	4	65	1	0	0	0	0	0	0	0	1	15648	912	32	1		1	TBX10	11	67402490	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	22617	67402490	67604026	843	19876										
MYEOV	26579	broad.mit.edu	37	chr11	69063227	69063257	+	Frame_Shift_Del	DEL	GGTGACCGGGAGAGAAACAAGGGAGACAAGG	GGTGACCGGGAGAGAAACAAGGGAGACAAGG	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtggtttgctgctggagctGgtgaccgggagagaaacaag							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:69063227_69063257delGGTGACCGGGAGAGAAACAAGGGAGACAAGG	uc001oov.2	+	3	760_790	c.310_340delGGTGACCGGGAGAGAAACAAGGGAGACAAGG	c.(310-342)GGTGACCGGGAGAGAAACAAGGGAGACAAGGGTfs	p.G104fs	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Frame_Shift_Del_p.G104fs|MYEOV_uc001oow.2_Frame_Shift_Del_p.G46fs	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	104_114											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		TGCTGGAGCTGGTGACCGGGAGAGAAACAAGGGAGACAAGGGTGCCCAGAC	0.636																		17	154	---	---								-	69063257	GGTGACCGGGAGAGAAACAAGGGAGACAAGG	-	69063227	7	5	65	1	0	1	0	1	0	0	0	0	10025	1348	47	0	316	0	MYEOV	11	69063227	Frame_Shift_Del	DEL	GGTGACCGGGAGAGAAACAAGGGAGACAAGG	TCGA-DK-A3WW-01A-22D-A23M-08	1660737	69063227	65943289	844	19877										
PDE2A	5138	broad.mit.edu	37	chr11	72294523	72294523	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcattggccaggtggctgcGatactgagcctcattcactt	10	12	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:72294523G>A	uc010rrc.1	-	20	1930	c.1687C>T	c.(1687-1689)CGC>TGC	p.R563C	PDE2A_uc001oso.2_Missense_Mutation_p.R542C|PDE2A_uc010rra.1_Missense_Mutation_p.R556C|PDE2A_uc001osn.2_Missense_Mutation_p.R307C|PDE2A_uc010rrb.1_Missense_Mutation_p.R554C|PDE2A_uc010rrd.1_Missense_Mutation_p.R448C	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	563					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AGGTGGCTGCGATACTGAGCC	0.537													0	0	0	1	0	31	80										A	72294523	G	A	72294523	3	1	65	1	0	0	0	0	1	0	0	0	11636	1058	37	1	1186	1	PDE2A	11	72294523	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3231296	72294523	62711993	845	19878										
ARAP1	116985	broad.mit.edu	37	chr11	72418254	72418254	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagataacaacacagaggttGatggaggcccagtcaggctg	13	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:72418254G>C	uc001osu.2	-	12	1878	c.1689C>G	c.(1687-1689)ATC>ATG	p.I563M	ARAP1_uc001osv.2_Missense_Mutation_p.I563M|ARAP1_uc001osr.2_Missense_Mutation_p.I323M|ARAP1_uc001oss.2_Missense_Mutation_p.I318M|ARAP1_uc009yth.2_Missense_Mutation_p.I318M|ARAP1_uc010rre.1_Missense_Mutation_p.I318M	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	563	C4-type.|Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CACAGAGGTTGATGGAGGCCC	0.647													0	0	0	1	0	5	22										C	72418254	G	C	72418254	3	2	65	1	0	0	0	0	1	0	0	0	838	1280	45	1	2759	1	ARAP1	11	72418254	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	123731	72418254	62588262	846	19879										
PRKRIR	5612	broad.mit.edu	37	chr11	76063335	76063335	+	Missense_Mutation	SNP	G	G	C													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaattcctctcttaggttatGagattcatcaacaaacctca							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:76063335G>C	uc001oxh.1	-	5	859	c.859C>G	c.(859-861)CAT>GAT	p.H287D	PRKRIR_uc010rrz.1_Missense_Mutation_p.H112D	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	287					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CTTAGGTTATGAGATTCATCA	0.423													0	0	0	1	0	7	34										C	76063335	G	C	76063335	3	2	65	1	0	0	0	0	1	0	0	0	12526	1290	45	1	1430	1	PRKRIR	11	76063335	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3645081	76063335	58943181	847	19880	99	2								
PRKRIR	5612	broad.mit.edu	37	chr11	76063340	76063340	+	Missense_Mutation	SNP	T	T	C													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctctcttaggttatgagatTcatcaacaaacctcaccaac							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:76063340T>C	uc001oxh.1	-	5	854	c.854A>G	c.(853-855)GAA>GGA	p.E285G	PRKRIR_uc010rrz.1_Missense_Mutation_p.E110G	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	285					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						GTTATGAGATTCATCAACAAA	0.428													0	0	0	1	0	6	32										C	76063340	T	C	76063340	3	2	65	1	0	0	0	0	1	0	0	0	12526	1783	62	5	1435	5	PRKRIR	11	76063340	Missense_Mutation	SNP	T	TCGA-DK-A3WW-01A-22D-A23M-08	5	76063340	58943176	848	19881	99	2								
PRKRIR	5612	broad.mit.edu	37	chr11	76063502	76063502	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgcctctgctgtgtttttGaacaaaacaacgtgttaact	7	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:76063502G>C	uc001oxh.1	-	5	692	c.692C>G	c.(691-693)TCA>TGA	p.S231*	PRKRIR_uc010rrz.1_Nonsense_Mutation_p.S56*	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	231					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CTGTGTTTTTGAACAAAACAA	0.438													0	0	0	1	0	11	32										C	76063502	G	C	76063502	4	2	65	1	0	0	0	0	0	1	0	0	12526	1294	45	1	1597	1	PRKRIR	11	76063502	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	162	76063502	58943014	849	19882										
NARS2	79731	broad.mit.edu	37	chr11	78177018	78177018	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtatgttgccacagtgcttCaccaggtacttttcatgttc	9	10	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:78177018C>T	uc001ozi.2	-	11	1444	c.1068G>A	c.(1066-1068)GTG>GTA	p.V356V	NARS2_uc010rsq.1_Silent_p.V129V	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	356					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CACAGTGCTTCACCAGGTACT	0.418													0	0	0	1	0	19	47										T	78177018	C	T	78177018	2	4	65	1	0	0	0	0	0	0	0	1	10171	813	29	1		1	NARS2	11	78177018	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2113516	78177018	56829498	850	19883										
C11orf82	220042	broad.mit.edu	37	chr11	82644076	82644076	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagaatctcaccacacaggGagagtgaccattctagtcta	8	11	4	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:82644076G>A	uc001ozt.2	+	6	1940	c.1696G>A	c.(1696-1698)GAG>AAG	p.E566K	C11orf82_uc010rsr.1_Missense_Mutation_p.E265K|C11orf82_uc010rss.1_Missense_Mutation_p.E265K|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	566					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						ACCACACAGGGAGAGTGACCA	0.338													0	0	0	1	0	13	19										A	82644076	G	A	82644076	3	1	65	1	0	0	0	0	1	0	0	0	1665	1175	41	1	1710	1	C11orf82	11	82644076	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4467058	82644076	52362440	851	19884										
DLG2	1740	broad.mit.edu	37	chr11	83173066	83173066	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtaaaatattctccaaattCttgttctagcttaattgctc	4	8	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:83173066C>T	uc001paj.2	-	22	2788	c.2485G>A	c.(2485-2487)GAA>AAA	p.E829K	DLG2_uc001pai.2_Missense_Mutation_p.E708K|DLG2_uc010rsy.1_Missense_Mutation_p.E778K|DLG2_uc010rsz.1_Missense_Mutation_p.E825K|DLG2_uc010rta.1_Missense_Mutation_p.E811K|DLG2_uc001pak.2_Missense_Mutation_p.E934K|DLG2_uc010rtb.1_Missense_Mutation_p.E796K|DLG2_uc010rsw.1_Missense_Mutation_p.E293K|DLG2_uc010rsx.1_Missense_Mutation_p.E306K	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	829	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCTCCAAATTCTTGTTCTAGC	0.408													0	0	0	1	0	9	35										T	83173066	C	T	83173066	3	4	65	1	0	0	0	0	1	0	0	0	4555	922	32	1	135	1	DLG2	11	83173066	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	528990	83173066	51833450	852	19885										
DLG2	1740	broad.mit.edu	37	chr11	83195218	83195218	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgctccttgttcttgtaGaatgggaattttcgtgaaaa	9	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:83195218G>C	uc001paj.2	-	17	2235	c.1932C>G	c.(1930-1932)TTC>TTG	p.F644L	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Intron|DLG2_uc010rsz.1_Intron|DLG2_uc010rta.1_Intron|DLG2_uc001pak.2_Missense_Mutation_p.F749L|DLG2_uc010rtb.1_Missense_Mutation_p.F611L|DLG2_uc010rsw.1_Intron|DLG2_uc010rsx.1_Intron	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	644						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TGTTCTTGTAGAATGGGAATT	0.393													0	0	0	1	0	20	85										C	83195218	G	C	83195218	3	2	65	1	0	0	0	0	1	0	0	0	4555	933	33	1	758	1	DLG2	11	83195218	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	22152	83195218	51811298	853	19886										
CCDC89	220388	broad.mit.edu	37	chr11	85396921	85396921	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagcgctccagggcctcatCtgacctccgcttcaggatgc	11	16	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:85396921C>G	uc001pau.1	-	1	400	c.253G>C	c.(253-255)GAT>CAT	p.D85H		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	85	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AGGGCCTCATCTGACCTCCGC	0.592													0	0	0	1	0	22	59										G	85396921	C	G	85396921	3	3	65	1	0	0	0	0	1	0	0	0	2866	913	32	1	875	1	CCDC89	11	85396921	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2201703	85396921	49609595	854	19887										
CCDC67	159989	broad.mit.edu	37	chr11	93118581	93118581	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggccatggaagcaggtctCtcagaggtaaaaagtgagtt	13	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:93118581C>G	uc001pdq.2	+	8	907	c.807C>G	c.(805-807)CTC>CTG	p.L269L	CCDC67_uc001pdo.1_Silent_p.L269L|CCDC67_uc001pdp.2_Silent_p.L269L	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	269	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AAGCAGGTCTCTCAGAGGTAA	0.313													0	0	0	1	0	8	36										G	93118581	C	G	93118581	2	3	65	1	0	0	0	0	0	0	0	1	2839	900	32	1		1	CCDC67	11	93118581	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7721660	93118581	41887935	855	19888										
MTMR2	8898	broad.mit.edu	37	chr11	95590723	95590723	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaaagtacatacctgccttCtatactctaaaagagggtca	7	9	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:95590723C>T	uc001pfu.2	-	7	900	c.647G>A	c.(646-648)AGA>AAA	p.R216K	MTMR2_uc001pfv.2_Missense_Mutation_p.R144K|MTMR2_uc001pfs.2_Missense_Mutation_p.R144K|MTMR2_uc001pft.2_Missense_Mutation_p.R144K|MTMR2_uc010ruj.1_Missense_Mutation_p.R199K	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	216	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TACCTGCCTTCTATACTCTAA	0.338													0	0	0	1	0	5	24										T	95590723	C	T	95590723	3	4	65	1	0	0	0	0	1	0	0	0	9944	913	32	1	1320	1	MTMR2	11	95590723	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2472142	95590723	39415793	856	19889										
MAML2	84441	broad.mit.edu	37	chr11	95826490	95826490	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttcgcaggggtgcttggctCataggcaaggtccctgacat	13	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:95826490C>G	uc001pfw.1	-	2	1990	c.705G>C	c.(703-705)ATG>ATC	p.M235I		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	235					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				GTGCTTGGCTCATAGGCAAGG	0.468			T	MECT1|CRTC3	salivary gland mucoepidermoid								0	0	0	1	0	15	56										G	95826490	C	G	95826490	3	3	65	1	0	0	0	0	1	0	0	0	9206	826	29	1	2781	1	MAML2	11	95826490	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	235767	95826490	39180026	857	19890										
PGR	5241	broad.mit.edu	37	chr11	100998975	100998975	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagggcgaccctgggcgctGagaagcgggaatcttccttg	15	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:100998975G>A	uc001pgh.2	-	1	1570	c.827C>T	c.(826-828)TCA>TTA	p.S276L	PGR_uc001pgi.2_Missense_Mutation_p.S276L|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	276	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCTGGGCGCTGAGAAGCGGGA	0.731													0	0	0	1	0	7	18										A	100998975	G	A	100998975	3	1	65	1	0	0	0	0	1	0	0	0	11805	1294	45	1	2006	1	PGR	11	100998975	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5172485	100998975	34007541	858	19891										
TMEM123	114908	broad.mit.edu	37	chr11	102272716	102272716	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattgtggatgttgatatctGagatgtgttctgtgaaacac	11	5	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:102272716G>C	uc001pha.2	-	3	800	c.379C>G	c.(379-381)CAG>GAG	p.Q127E	TMEM123_uc009yxc.2_Missense_Mutation_p.Q108E	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	127	Thr-rich.|Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		GTTGATATCTGAGATGTGTTC	0.388													0	0	0	1	0	39	100										C	102272716	G	C	102272716	3	2	65	1	0	0	0	0	1	0	0	0	16033	1299	45	1	259	1	TMEM123	11	102272716	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1273741	102272716	32733800	859	19892										
MMP12	4321	broad.mit.edu	37	chr11	102742592	102742592	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgttaatcttgctgaatttCaagggggtaacattactcca	9	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:102742592C>G	uc001phk.2	-	3	486	c.441G>C	c.(439-441)TTG>TTC	p.L147F		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	147					positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGCTGAATTTCAAGGGGGTAA	0.418													0	0	0	1	0	9	19										G	102742592	C	G	102742592	3	3	65	1	0	0	0	0	1	0	0	0	9651	825	29	1	1002	1	MMP12	11	102742592	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	469876	102742592	32263924	860	19893										
KIAA1826	84437	broad.mit.edu	37	chr11	105880615	105880615	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatttgtaggcgttccttttCtacctgcagcctttcggcct	9	12	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:105880615C>T	uc001piy.2	-	3	858	c.685G>A	c.(685-687)GAA>AAA	p.E229K	KIAA1826_uc001piz.2_Missense_Mutation_p.E229K	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	229	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		CGTTCCTTTTCTACCTGCAGC	0.463													0	0	0	1	0	17	85										T	105880615	C	T	105880615	3	4	65	1	0	0	0	0	1	0	0	0	8260	922	32	1	356	1	KIAA1826	11	105880615	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3138023	105880615	29125901	861	19894										
GUCY1A2	2977	broad.mit.edu	37	chr11	106888480	106888480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttccgccccccgctcaccGagggcgccgtcaggcggctg	13	20	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:106888480G>A	uc001pjg.1	-	1	692	c.302C>T	c.(301-303)TCG>TTG	p.S101L	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S101L|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S101L	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	101					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CCCGCTCACCGAGGGCGCCGT	0.662													0	0	0	1	0	6	11										A	106888480	G	A	106888480	3	1	65	1	0	0	0	0	1	0	0	0	6893	1072	37	1	1928	1	GUCY1A2	11	106888480	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1007865	106888480	28118036	862	19895										
ATM	472	broad.mit.edu	37	chr11	108192065	108192065	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agatgtgtaagcgcagccttGagtctgtgtattcgctctat	11	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:108192065G>C	uc001pkb.1	+	45	6875	c.6490G>C	c.(6490-6492)GAG>CAG	p.E2164Q	ATM_uc009yxr.1_Missense_Mutation_p.E2164Q|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E816Q|ATM_uc001pkg.1_Missense_Mutation_p.E521Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2164	FAT.		E -> K (in T-prolymphocytic leukemia).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.E2164K(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCGCAGCCTTGAGTCTGTGTA	0.413			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	1	0	29	119										C	108192065	G	C	108192065	3	2	65	1	0	0	0	0	1	0	0	0	1109	1291	45	1	6664	1	ATM	11	108192065	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1303585	108192065	26814451	863	19896										
ATM	472	broad.mit.edu	37	chr11	108196791	108196791	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattttcatttcagctccctGaaagggcaatatttcaaatt	5	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:108196791G>T	uc001pkb.1	+	47	7199	c.6814G>T	c.(6814-6816)GAA>TAA	p.E2272*	ATM_uc009yxr.1_Nonsense_Mutation_p.E2272*|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Nonsense_Mutation_p.E924*|ATM_uc001pkg.1_Nonsense_Mutation_p.E629*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2272	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TCAGCTCCCTGAAAGGGCAAT	0.338			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			1	0	0.00621372	1	0.00626926	8	34										T	108196791	G	T	108196791	4	4	65	1	0	0	0	0	0	1	0	0	1109	1291	45	3	6996	3	ATM	11	108196791	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4726	108196791	26809725	864	19897										
EXPH5	23086	broad.mit.edu	37	chr11	108382527	108382527	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatcttcatcaccagaaacaGaaaacgtactagtcgtctta	5	10	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:108382527G>A	uc001pkk.2	-	6	3818	c.3707C>T	c.(3706-3708)TCT>TTT	p.S1236F	EXPH5_uc010rvy.1_Missense_Mutation_p.S1048F|EXPH5_uc010rvz.1_Missense_Mutation_p.S1080F|EXPH5_uc010rwa.1_Missense_Mutation_p.S1160F	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1236					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		ACCAGAAACAGAAAACGTACT	0.373													0	0	0	1	0	19	61										A	108382527	G	A	108382527	3	1	65	1	0	0	0	0	1	0	0	0	5322	942	33	1	2266	1	EXPH5	11	108382527	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	185736	108382527	26623989	865	19898										
DDX10	1662	broad.mit.edu	37	chr11	108547945	108547945	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaaagaatcatgacttctCagctggtctcatcattggtg	10	8	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:108547945C>A	uc001pkm.2	+	4	577	c.512C>A	c.(511-513)TCA>TAA	p.S171*	DDX10_uc001pkl.1_Nonsense_Mutation_p.S171*	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	171	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		CATGACTTCTCAGCTGGTCTC	0.468			T	NUP98	AML*								1	0	1.06801e-11	1	1.11821e-11	29	111										A	108547945	C	A	108547945	4	1	65	1	0	0	0	0	0	1	0	0	4342	838	29	3	526	3	DDX10	11	108547945	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	165418	108547945	26458571	866	19899										
DDX10	1662	broad.mit.edu	37	chr11	108811112	108811112	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctgtctttagcagaggatGaagagctggtgttacatctg	13	7	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:108811112G>A	uc001pkm.2	+	18	2655	c.2590G>A	c.(2590-2592)GAA>AAA	p.E864K		NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	864							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AGCAGAGGATGAAGAGCTGGT	0.478			T	NUP98	AML*								0	0	0	1	0	7	56										A	108811112	G	A	108811112	3	1	65	1	0	0	0	0	1	0	0	0	4342	1291	45	1	2660	1	DDX10	11	108811112	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	263167	108811112	26195404	867	19900										
C11orf1	64776	broad.mit.edu	37	chr11	111754506	111754506	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttccctcaggatttaagcgaGagcctcactggttcccagga	10	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:111754506G>A	uc001pmd.2	+	4	692	c.355G>A	c.(355-357)GAG>AAG	p.E119K	C11orf1_uc001pme.2_Missense_Mutation_p.E159K	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	119						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		ATTTAAGCGAGAGCCTCACTG	0.393													0	0	0	1	0	17	49										A	111754506	G	A	111754506	3	1	65	1	0	0	0	0	1	0	0	0	1629	943	33	1	369	1	C11orf1	11	111754506	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2943394	111754506	23252010	868	19901										
DIXDC1	85458	broad.mit.edu	37	chr11	111888513	111888513	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgttgcaggttggaggaggtGacgttaaaggattttaaagc	15	3	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:111888513G>A	uc001pml.2	+	20	2172	c.1875G>A	c.(1873-1875)GTG>GTA	p.V625V	DIXDC1_uc001pmm.2_Silent_p.V414V|DIXDC1_uc001pmn.2_Silent_p.V331V|DIXDC1_uc010rwq.1_Silent_p.V290V	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	625	DIX.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		TGGAGGAGGTGACGTTAAAGG	0.433													0	0	0	1	0	3	15										A	111888513	G	A	111888513	2	1	65	1	0	0	0	0	0	0	0	1	4541	1277	45	1		1	DIXDC1	11	111888513	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	134007	111888513	23118003	869	19902										
ZW10	9183	broad.mit.edu	37	chr11	113631013	113631013	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgttctgtttctgtattgtGagctccatgctgagagattt	10	6	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:113631013G>C	uc001poe.2	-	5	535	c.498C>G	c.(496-498)CTC>CTG	p.L166L	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	166	Interaction with RINT1.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TCTGTATTGTGAGCTCCATGC	0.393													0	0	0	1	0	11	41										C	113631013	G	C	113631013	2	2	65	1	0	0	0	0	0	0	0	1	18244	1277	45	1		1	ZW10	11	113631013	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1742500	113631013	21375503	870	19903										
NNMT	4837	broad.mit.edu	37	chr11	114168699	114168699	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaagggagacctgctgattGacatcggctctggccccact	12	12	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:114168699G>A	uc001por.1	+	4	445	c.181G>A	c.(181-183)GAC>AAC	p.D61N	NNMT_uc001pos.1_Missense_Mutation_p.D61N	NM_006169	NP_006160	P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	61					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			ovary(1)	1		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	CCTGCTGATTGACATCGGCTC	0.507													0	0	0	1	0	15	85										A	114168699	G	A	114168699	3	1	65	1	0	0	0	0	1	0	0	0	10509	1290	45	1	187	1	NNMT	11	114168699	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	537686	114168699	20837817	871	19904										
CEP164	22897	broad.mit.edu	37	chr11	117244524	117244524	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctcagactccatagcttctGaccccaagtccttccatggc	6	16	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:117244524G>A	uc001prc.2	+	10	1357	c.1210G>A	c.(1210-1212)GAC>AAC	p.D404N	CEP164_uc001prb.2_Missense_Mutation_p.D404N|CEP164_uc010rxk.1_Missense_Mutation_p.D378N|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	404					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CATAGCTTCTGACCCCAAGTC	0.343													0	0	0	1	0	24	54										A	117244524	G	A	117244524	3	1	65	1	0	0	0	0	1	0	0	0	3249	1290	45	1	1240	1	CEP164	11	117244524	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3075825	117244524	17761992	872	19905										
DSCAML1	57453	broad.mit.edu	37	chr11	117308767	117308767	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaacacatccttccactcctCgctgttgtccaccgagtact	6	16	0	0	rs140883925		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:117308767C>G	uc001prh.1	-	25	4458	c.4456G>C	c.(4456-4458)GAG>CAG	p.E1486Q		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1426	Fibronectin type-III 5.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TTCCACTCCTCGCTGTTGTCC	0.602													0	0	0	1	0	17	43										G	117308767	C	G	117308767	3	3	65	1	0	0	0	0	1	0	0	0	4769	893	31	1	1921	1	DSCAML1	11	117308767	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	64243	117308767	17697749	873	19906										
TMPRSS4	56649	broad.mit.edu	37	chr11	117988106	117988106	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggctatggctgcgggggcccGagcaccccaggagtatacac	15	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:117988106G>A	uc010rxo.1	+	12	1530	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	TMPRSS4_uc010rxp.1_Silent_p.P408P|TMPRSS4_uc010rxq.1_Silent_p.P266P|TMPRSS4_uc010rxr.1_Silent_p.P388P|TMPRSS4_uc010rxs.1_Silent_p.P373P|TMPRSS4_uc009yzu.2_RNA|TMPRSS4_uc010rxt.1_Silent_p.P388P	NM_019894	NP_063947	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4 isoform 1	413	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		GCGGGGGCCCGAGCACCCCAG	0.572													0	0	0	1	0	48	163										A	117988106	G	A	117988106	2	1	65	1	0	0	0	0	0	0	0	1	16246	1045	37	1		1	TMPRSS4	11	117988106	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	679339	117988106	17018410	874	19907										
ZNF202	7753	broad.mit.edu	37	chr11	123597521	123597521	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgaaggttcacaaaactattCacttgagaaatattagtacc	6	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:123597521C>T	uc001pzd.1	-	9	1531	c.1131G>A	c.(1129-1131)GTG>GTA	p.V377V	ZNF202_uc001pzc.1_Silent_p.V153V|ZNF202_uc001pze.1_Silent_p.V377V|ZNF202_uc001pzf.1_Silent_p.V377V	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	377					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CAAAACTATTCACTTGAGAAA	0.433													0	0	0	1	0	21	107										T	123597521	C	T	123597521	2	4	65	1	0	0	0	0	0	0	0	1	17760	813	29	1		1	ZNF202	11	123597521	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5609415	123597521	11408995	875	19908										
ROBO4	54538	broad.mit.edu	37	chr11	124766975	124766975	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagcagcagaagggtcccatCaggcaggaggtggtgtgggt	18	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:124766975C>G	uc001qbg.2	-	2	393	c.253G>C	c.(253-255)GAT>CAT	p.D85H	ROBO4_uc010sas.1_Intron|ROBO4_uc001qbh.2_Intron|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	85	Ig-like C2-type 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		AGGGTCCCATCAGGCAGGAGG	0.657													0	0	0	1	0	7	31										G	124766975	C	G	124766975	3	3	65	1	0	0	0	0	1	0	0	0	13516	826	29	1	2838	1	ROBO4	11	124766975	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1169454	124766975	10239541	876	19909										
SRPR	6734	broad.mit.edu	37	chr11	126137185	126137185	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttcagaatcttcaaatttCttcatggtagtgggagcacg	9	7	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:126137185C>G	uc001qdh.2	-	4	462	c.411G>C	c.(409-411)AAG>AAC	p.K137N	SRPR_uc010sbm.1_Missense_Mutation_p.K109N|FOXRED1_uc001qdi.2_5'Flank|FOXRED1_uc010sbn.1_5'Flank|FOXRED1_uc010sbo.1_5'Flank|FOXRED1_uc010sbp.1_5'Flank|FOXRED1_uc010sbq.1_5'Flank|FOXRED1_uc001qdj.2_5'Flank|FOXRED1_uc010sbr.1_5'Flank	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	137					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		CTTCAAATTTCTTCATGGTAG	0.418													0	0	0	1	0	47	125										G	126137185	C	G	126137185	3	3	65	1	0	0	0	0	1	0	0	0	15161	912	32	1	1549	1	SRPR	11	126137185	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1370210	126137185	8869331	877	19910										
FOXRED1	55572	broad.mit.edu	37	chr11	126142911	126142911	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtaggtgggatttgtcagcaGttctcattgcctgagaacat	12	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:126142911G>A	uc001qdi.2	+	3	401	c.354G>A	c.(352-354)CAG>CAA	p.Q118Q	FOXRED1_uc010sbn.1_5'UTR|FOXRED1_uc010sbo.1_RNA|FOXRED1_uc010sbp.1_5'UTR|FOXRED1_uc010sbq.1_5'UTR|FOXRED1_uc001qdj.2_5'UTR|FOXRED1_uc010sbr.1_Silent_p.Q104Q|FOXRED1_uc001qdk.2_5'UTR	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	118						integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		TTTGTCAGCAGTTCTCATTGC	0.483													0	0	0	1	0	25	76										A	126142911	G	A	126142911	2	1	65	1	0	0	0	0	0	0	0	1	6033	1020	36	2		2	FOXRED1	11	126142911	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5726	126142911	8863605	878	19911										
NFRKB	4798	broad.mit.edu	37	chr11	129744722	129744722	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctccggtcacgatgcaggtaGatccacagctttcgtccaat	9	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:129744722G>A	uc001qfi.2	-	19	2145	c.1944C>T	c.(1942-1944)ATC>ATT	p.I648I	NFRKB_uc001qfg.2_Silent_p.I673I|NFRKB_uc001qfh.2_Silent_p.I671I|NFRKB_uc010sbw.1_Silent_p.I658I|NFRKB_uc009zcr.2_5'UTR	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	648					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GATGCAGGTAGATCCACAGCT	0.488													0	0	0	1	0	45	147										A	129744722	G	A	129744722	2	1	65	1	0	0	0	0	0	0	0	1	10384	932	33	1		1	NFRKB	11	129744722	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3601811	129744722	5261794	879	19912										
B3GAT1	27087	broad.mit.edu	37	chr11	134252640	134252640	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccttgggctccaggtcgttGagggtgacaagttctcgaag	15	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr11:134252640G>A	uc001qhq.2	-	5	1143	c.882C>T	c.(880-882)CTC>CTT	p.L294L	B3GAT1_uc001qhr.2_Silent_p.L294L|B3GAT1_uc010scv.1_Silent_p.L307L	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	294	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		CCAGGTCGTTGAGGGTGACAA	0.572													0	0	0	1	0	15	64										A	134252640	G	A	134252640	2	1	65	1	0	0	0	0	0	0	0	1	1253	1277	45	1		1	B3GAT1	11	134252640	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4507918	134252640	753876	880	19913										
CCDC77	84318	broad.mit.edu	37	chr12	549890	549890	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attcgtgaggaagagggaatGaggagagagatcttcaaggt	16	3	2	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:549890G>A	uc001qig.2	+	11	1329	c.1149G>A	c.(1147-1149)ATG>ATA	p.M383I	CCDC77_uc009zdk.2_Missense_Mutation_p.M351I|CCDC77_uc010sdp.1_Missense_Mutation_p.M351I|CCDC77_uc010sdq.1_Missense_Mutation_p.M351I	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	383	Potential.					centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AAGAGGGAATGAGGAGAGAGA	0.438													0	0	0	1	0	12	45										A	549890	G	A	549890	3	1	65	1	0	0	0	0	1	0	0	0	2851	1290	45	1	1183	1	CCDC77	12	549890	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		549890	133302005	881	19914										
WNK1	65125	broad.mit.edu	37	chr12	1005785	1005785	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaaagagccttcctagccaGaatctaagtcaaagccttag	7	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:1005785G>C	uc001qio.3	+	24	6639	c.6132G>C	c.(6130-6132)CAG>CAC	p.Q2044H	WNK1_uc001qip.3_Missense_Mutation_p.Q1796H|WNK1_uc001qir.3_Missense_Mutation_p.Q1217H	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2044					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TTCCTAGCCAGAATCTAAGTC	0.463													0	0	0	1	0	12	41										C	1005785	G	C	1005785	3	2	65	1	0	0	0	0	1	0	0	0	17374	933	33	1	7728	1	WNK1	12	1005785	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	455895	1005785	132846110	882	19915										
DCP1B	196513	broad.mit.edu	37	chr12	2113469	2113469	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cactcgttggcccgatggccGaaggtgtacagagccacctg	13	13	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:2113469G>T	uc001qjx.1	-	1	209	c.129C>A	c.(127-129)TTC>TTA	p.F43L	DCP1B_uc010sdy.1_5'UTR|DCP1B_uc010sdz.1_Missense_Mutation_p.F43L	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	43					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			CCCGATGGCCGAAGGTGTACA	0.682													1	0	4.68919e-08	1	4.86744e-08	11	43										T	2113469	G	T	2113469	3	4	65	1	0	0	0	0	1	0	0	0	4299	1049	37	3	1760	3	DCP1B	12	2113469	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1107684	2113469	131738426	883	19916										
CACNA1C	775	broad.mit.edu	37	chr12	2224703	2224703	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggcctgcatcagcattgtCgaatggaaatatcctttgtt	10	8	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:2224703C>G	uc009zdu.1	+	2	676	c.363C>G	c.(361-363)GTC>GTG	p.V121V	CACNA1C_uc009zdv.1_Silent_p.V121V|CACNA1C_uc001qkb.2_Silent_p.V121V|CACNA1C_uc001qkc.2_Silent_p.V121V|CACNA1C_uc001qke.2_Silent_p.V121V|CACNA1C_uc001qkf.2_Silent_p.V121V|CACNA1C_uc001qjz.2_Silent_p.V121V|CACNA1C_uc001qkd.2_Silent_p.V121V|CACNA1C_uc001qkg.2_Silent_p.V121V|CACNA1C_uc009zdw.1_Silent_p.V121V|CACNA1C_uc001qkh.2_Silent_p.V121V|CACNA1C_uc001qkl.2_Silent_p.V121V|CACNA1C_uc001qkn.2_Silent_p.V121V|CACNA1C_uc001qko.2_Silent_p.V121V|CACNA1C_uc001qkp.2_Silent_p.V121V|CACNA1C_uc001qkr.2_Silent_p.V121V|CACNA1C_uc001qku.2_Silent_p.V121V|CACNA1C_uc001qkq.2_Silent_p.V121V|CACNA1C_uc001qks.2_Silent_p.V121V|CACNA1C_uc001qkt.2_Silent_p.V121V	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	121	Cytoplasmic (Potential).|I.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCAGCATTGTCGAATGGAAAT	0.647													0	0	0	1	0	20	77										G	2224703	C	G	2224703	2	3	65	1	0	0	0	0	0	0	0	1	2540	871	31	1		1	CACNA1C	12	2224703	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	111234	2224703	131627192	884	19917										
GPR162	27239	broad.mit.edu	37	chr12	6933172	6933172	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccaatgcctggatcatcctCagcatctcggccaagcagca	9	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:6933172C>G	uc001qqw.1	+	2	643	c.108C>G	c.(106-108)CTC>CTG	p.L36L	GPR162_uc010sfn.1_Silent_p.L36L|GPR162_uc001qqx.1_Intron|GPR162_uc009zfd.1_Intron|GPR162_uc001qqy.1_5'Flank	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	36	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGATCATCCTCAGCATCTCGG	0.657													0	0	0	1	0	15	34										G	6933172	C	G	6933172	2	3	65	1	0	0	0	0	0	0	0	1	6666	813	29	1		1	GPR162	12	6933172	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4708469	6933172	126918723	885	19918										
TAS2R43	259289	broad.mit.edu	37	chr12	11244734	11244734	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtctcttgaaccactcaatgGaatttaccagtgctatgaag	8	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:11244734G>A	uc001qzq.1	-	1	179	c.95C>T	c.(94-96)TCC>TTC	p.S32F	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176884	NP_795365	P59537	T2R43_HUMAN	taste receptor, type 2, member 43	32	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	cilium membrane|motile cilium	bitter taste receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		CCACTCAATGGAATTTACCAG	0.388													0	0	0	1	0	12	52										A	11244734	G	A	11244734	3	1	65	1	0	0	0	0	1	0	0	0	15578	1174	41	1	838	1	TAS2R43	12	11244734	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4311562	11244734	122607161	886	19919										
ETV6	2120	broad.mit.edu	37	chr12	12022357	12022357	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtctttccctctgctccacaGataactgtgtccagaggacc	8	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:12022357G>T	uc001qzz.2	+	5	738	c.464_splice	c.e5-1	p.D155_splice	ETV6_uc001raa.1_5'Flank	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6							cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CTGCTCCACAGATAACTGTGT	0.552			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								1	0	4.14481e-20	1	4.40223e-20	38	130										T	12022357	G	T	12022357	5	4	65	1	0	0	0	0	0	0	1	0	5283	956	33	3	481	3	ETV6	12	12022357	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	777623	12022357	121829538	887	19920										
GRIN2B	2904	broad.mit.edu	37	chr12	13769390	13769390	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattgagaggatgccatactCagtgactatgcgtttttggc	11	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:13769390C>T	uc001rbt.2	-	5	1506	c.1327G>A	c.(1327-1329)GAG>AAG	p.E443K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	443	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCATACTCAGTGACTATG	0.527													0	0	0	1	0	16	50										T	13769390	C	T	13769390	3	4	65	1	0	0	0	0	1	0	0	0	6780	840	29	1	3163	1	GRIN2B	12	13769390	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1747033	13769390	120082505	888	19921										
ERP27	121506	broad.mit.edu	37	chr12	15068615	15068615	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccactgtccaccagaataaaGagaatctgcagttggggaag	11	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:15068615G>A	uc001rco.2	-	6	603	c.582C>T	c.(580-582)CTC>CTT	p.L194L		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	194						endoplasmic reticulum lumen				breast(1)	1						CCAGAATAAAGAGAATCTGCA	0.403													0	0	0	1	0	11	41										A	15068615	G	A	15068615	2	1	65	1	0	0	0	0	0	0	0	1	5241	929	33	1		1	ERP27	12	15068615	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1299225	15068615	118783280	889	19922										
C12orf11	55726	broad.mit.edu	37	chr12	27066474	27066474	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctttgtcttccctctttcttCctcgtttctttcgttcttcc	3	15	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:27066474C>T	uc001rhk.3	-	14	2258	c.1721G>A	c.(1720-1722)GGA>GAA	p.G574E	C12orf11_uc001rhj.3_Missense_Mutation_p.G142E|C12orf11_uc010sjk.1_Missense_Mutation_p.G473E	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	574	Potential.				cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					CCTCTTTCTTCCTCGTTTCTT	0.448													0	0	0	1	0	67	234										T	27066474	C	T	27066474	3	4	65	1	0	0	0	0	1	0	0	0	1675	855	30	1	415	1	C12orf11	12	27066474	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11997859	27066474	106785421	890	19923										
ARNTL2	56938	broad.mit.edu	37	chr12	27543128	27543128	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gataaagagttgtaaaatctCtgtcaaagaagagcatggat	10	4	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:27543128C>A	uc001rht.1	+	9	893	c.875C>A	c.(874-876)TCT>TAT	p.S292Y	ARNTL2_uc001rhw.2_Missense_Mutation_p.S255Y|ARNTL2_uc010sjp.1_Missense_Mutation_p.S255Y|ARNTL2_uc001rhu.1_Missense_Mutation_p.S278Y|ARNTL2_uc009zji.1_Missense_Mutation_p.S258Y|ARNTL2_uc001rhv.1_Missense_Mutation_p.S244Y|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	292					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					TGTAAAATCTCTGTCAAAGAA	0.393													1	0	3.99206e-14	1	4.2057e-14	19	64										A	27543128	C	A	27543128	3	1	65	1	0	0	0	0	1	0	0	0	968	913	32	3	909	3	ARNTL2	12	27543128	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	476654	27543128	106308767	891	19924										
ARNTL2	56938	broad.mit.edu	37	chr12	27553558	27553558	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagaagaaaggaacagtaaGaaagacaacagtaattttac	9	4	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:27553558G>A	uc001rht.1	+	10	1029	c.1011G>A	c.(1009-1011)AAG>AAA	p.K337K	ARNTL2_uc001rhw.2_Silent_p.K300K|ARNTL2_uc010sjp.1_Silent_p.K300K|ARNTL2_uc001rhu.1_Silent_p.K323K|ARNTL2_uc009zji.1_Silent_p.K303K|ARNTL2_uc001rhv.1_Silent_p.K289K|uc001rhx.2_Intron	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	337					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					GGAACAGTAAGAAAGACAACA	0.378													0	0	0	1	0	23	50										A	27553558	G	A	27553558	2	1	65	1	0	0	0	0	0	0	0	1	968	933	33	1		1	ARNTL2	12	27553558	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	10430	27553558	106298337	892	19925										
C12orf40	283461	broad.mit.edu	37	chr12	40037702	40037702	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatggtaaatcagatatcttGcaagaagaaaattcctggta	8	5	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:40037702G>C	uc001rmc.2	+	3	352	c.185G>C	c.(184-186)TGC>TCC	p.C62S	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	62										ovary(6)	6						CAGATATCTTGCAAGAAGAAA	0.294													0	0	0	1	0	7	38										C	40037702	G	C	40037702	3	2	65	1	0	0	0	0	1	0	0	0	1686	1319	46	4	195	4	C12orf40	12	40037702	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	12484144	40037702	93814193	893	19926										
ADAMTS20	80070	broad.mit.edu	37	chr12	43826205	43826205	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcattcattgtcagcaagacGatggccaaagttattcatac	8	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:43826205G>A	uc010skx.1	-	21	2998	c.2998C>T	c.(2998-3000)CGT>TGT	p.R1000C	ADAMTS20_uc001rno.1_Missense_Mutation_p.R154C|ADAMTS20_uc001rnp.1_Missense_Mutation_p.R154C	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1000	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCAGCAAGACGATGGCCAAAG	0.433													0	0	0	1	0	18	70										A	43826205	G	A	43826205	3	1	65	1	0	0	0	0	1	0	0	0	266	1058	37	1	2809	1	ADAMTS20	12	43826205	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3788503	43826205	90025690	894	19927										
LALBA	3906	broad.mit.edu	37	chr12	48962944	48962944	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcttattactgatctggaaGagtccatattccgtgctttc	8	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:48962944G>C	uc001rrt.2	-	2	239	c.213C>G	c.(211-213)CTC>CTG	p.L71L		NM_002289	NP_002280	P00709	LALBA_HUMAN	lactalbumin, alpha- precursor	71					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity				0						TGATCTGGAAGAGTCCATATT	0.453													0	0	0	1	0	18	65										C	48962944	G	C	48962944	2	2	65	1	0	0	0	0	0	0	0	1	8604	929	33	1		1	LALBA	12	48962944	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5136739	48962944	84888951	895	19928										
CCNT1	904	broad.mit.edu	37	chr12	49087241	49087241	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcaatcttggctggatgatCaaacacagcccctccagtct	9	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49087241C>G	uc001rse.1	-	9	2079	c.1756G>C	c.(1756-1758)GAT>CAT	p.D586H	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.D301H	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	586	Ser-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						GCTGGATGATCAAACACAGCC	0.453													0	0	0	1	0	21	61										G	49087241	C	G	49087241	3	3	65	1	0	0	0	0	1	0	0	0	2934	826	29	1	428	1	CCNT1	12	49087241	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	124297	49087241	84764654	896	19929										
ADCY6	112	broad.mit.edu	37	chr12	49164698	49164698	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccctgaggcagccatgtagGtgctaccaatcgtcttgatc	11	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49164698G>A	uc001rsh.3	-	19	3767	c.3107C>T	c.(3106-3108)ACC>ATC	p.T1036I	ADCY6_uc001rsj.3_Missense_Mutation_p.T1036I|ADCY6_uc001rsi.3_Missense_Mutation_p.T983I|ADCY6_uc010slw.1_3'UTR	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	1036	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						AGCCATGTAGGTGCTACCAAT	0.582													0	0	0	1	0	30	74										A	49164698	G	A	49164698	3	1	65	1	0	0	0	0	1	0	0	0	298	1261	44	2	411	2	ADCY6	12	49164698	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	77457	49164698	84687197	897	19930										
ARF3	377	broad.mit.edu	37	chr12	49334843	49334843	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgcatctccttcttcccaatCaggctcttgagaaggtttcc	7	14	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49334843C>T	uc001rsr.2	-	2	289	c.36G>A	c.(34-36)CTG>CTA	p.L12L	ARF3_uc010smc.1_Silent_p.L12L	NM_001659	NP_001650	P61204	ARF3_HUMAN	ADP-ribosylation factor 3	12					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity				0						TCTTCCCAATCAGGCTCTTGA	0.547													0	0	0	1	0	53	191										T	49334843	C	T	49334843	2	4	65	1	0	0	0	0	0	0	0	1	845	813	29	1		1	ARF3	12	49334843	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	170145	49334843	84517052	898	19931										
PRKAG1	5571	broad.mit.edu	37	chr12	49406883	49406883	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccacagctggggagctatctGaagaaatgacctggagagat	13	8	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49406883G>C	uc001rsy.2	-	2	89	c.20C>G	c.(19-21)TCA>TGA	p.S7*	uc001rsw.2_Intron|PRKAG1_uc010smd.1_5'UTR|PRKAG1_uc001rsx.2_5'UTR|PRKAG1_uc001rsz.2_Nonsense_Mutation_p.S7*|PRKAG1_uc009zlb.2_5'UTR|PRKAG1_uc010sme.1_Nonsense_Mutation_p.S7*	NM_002733	NP_002724	P54619	AAKG1_HUMAN	AMP-activated protein kinase, noncatalytic	7					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1						GGAGCTATCTGAAGAAATGAC	0.423													0	0	0	1	0	10	48										C	49406883	G	C	49406883	4	2	65	1	0	0	0	0	0	1	0	0	12500	1294	45	1	1019	1	PRKAG1	12	49406883	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	72040	49406883	84445012	899	19932										
MLL2	8085	broad.mit.edu	37	chr12	49427438	49427438	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagccccaccagaatgttGctgttgctgctgttgggcca	11	13	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49427438G>A	uc001rta.3	-	39	11050	c.11050C>T	c.(11050-11052)CAA>TAA	p.Q3684*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3684	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAGAATGTTGCTGTTGCTGC	0.597			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	1	0	33	112										A	49427438	G	A	49427438	4	1	65	1	0	0	0	0	0	1	0	0	9621	1328	46	2	5627	2	MLL2	12	49427438	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	20555	49427438	84424457	900	19933										
DHH	50846	broad.mit.edu	37	chr12	49485101	49485101	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctcgtcccagccctcagtCactcgtaggcgcactccggg	10	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49485101C>T	uc001rtf.2	-	2	682	c.375G>A	c.(373-375)GTG>GTA	p.V125V		NM_021044	NP_066382	O43323	DHH_HUMAN	desert hedgehog preproprotein	125					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			lung(1)|breast(1)	2						AGCCCTCAGTCACTCGTAGGC	0.597													0	0	0	1	0	32	76										T	49485101	C	T	49485101	2	4	65	1	0	0	0	0	0	0	0	1	4483	813	29	1		1	DHH	12	49485101	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	57663	49485101	84366794	901	19934										
PRPH	5630	broad.mit.edu	37	chr12	49689307	49689307	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggagctcaacgaccgcttCgccaacttcatcgagaaggt	10	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49689307C>T	uc001rtu.2	+	1	399	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	108	Coil 1A.|Rod.						structural molecule activity				0						ACGACCGCTTCGCCAACTTCA	0.682													0	0	0	1	0	8	13										T	49689307	C	T	49689307	2	4	65	1	0	0	0	0	0	0	0	1	12576	883	31	1		1	PRPH	12	49689307	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	204206	49689307	84162588	902	19935										
MCRS1	10445	broad.mit.edu	37	chr12	49952459	49952459	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcttggcagcctcagccctGatgagggcaatgaggtcctg	13	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:49952459G>C	uc001ruk.1	-	15	1547	c.1356C>G	c.(1354-1356)ATC>ATG	p.I452M	MCRS1_uc001rui.1_Missense_Mutation_p.I465M|MCRS1_uc001ruj.1_Missense_Mutation_p.I439M|MCRS1_uc001rul.1_Missense_Mutation_p.I452M|MCRS1_uc009zlj.1_Missense_Mutation_p.I261M|MCRS1_uc001rum.1_Missense_Mutation_p.I439M	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	452					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						CCTCAGCCCTGATGAGGGCAA	0.607													0	0	0	1	0	18	71										C	49952459	G	C	49952459	3	2	65	1	0	0	0	0	1	0	0	0	9399	1280	45	1	36	1	MCRS1	12	49952459	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	263152	49952459	83899436	903	19936										
PRPF40B	25766	broad.mit.edu	37	chr12	50035705	50035705	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccacaggaccggggcttctgCgtggaggtgaacacggcctt	15	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:50035705C>T	uc001rur.1	+	18	1780	c.1716C>T	c.(1714-1716)TGC>TGT	p.C572C	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Silent_p.C594C|PRPF40B_uc001ruq.1_Intron|PRPF40B_uc001rus.1_Silent_p.C515C|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	572					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GGGGCTTCTGCGTGGAGGTGA	0.577													0	0	0	1	0	19	79										T	50035705	C	T	50035705	2	4	65	1	0	0	0	0	0	0	0	1	12572	776	27	2		2	PRPF40B	12	50035705	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	83246	50035705	83816190	904	19937										
ACCN2	41	broad.mit.edu	37	chr12	50453669	50453669	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctacgaccgagctgggcacGacattcgagacatgctgctc	11	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:50453669G>A	uc001rvw.2	+	3	719	c.490G>A	c.(490-492)GAC>AAC	p.D164N	ACCN2_uc001rvv.2_Missense_Mutation_p.D164N|ACCN2_uc009zln.2_5'UTR|ACCN2_uc009zlo.2_Missense_Mutation_p.D164N	NM_001095	NP_001086	P78348	ACCN2_HUMAN	amiloride-sensitive cation channel 2, neuronal	164	Extracellular (By similarity).				calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(1)	1					Amiloride(DB00594)	AGCTGGGCACGACATTCGAGA	0.567													0	0	0	1	0	10	40										A	50453669	G	A	50453669	3	1	65	1	0	0	0	0	1	0	0	0	129	1058	37	1	496	1	ACCN2	12	50453669	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	417964	50453669	83398226	905	19938										
GALNT6	11226	broad.mit.edu	37	chr12	51773340	51773340	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagagtctgctgggcttctgGagccctgatttggagcttgg	15	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:51773340G>C	uc001ryk.2	-	2	451	c.226C>G	c.(226-228)CCA>GCA	p.P76A	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.P76A|GALNT6_uc010snh.1_Missense_Mutation_p.P76A	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	76	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						TGGGCTTCTGGAGCCCTGATT	0.562													0	0	0	1	0	42	91										C	51773340	G	C	51773340	3	2	65	1	0	0	0	0	1	0	0	0	6217	1174	41	1	1682	1	GALNT6	12	51773340	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1319671	51773340	82078555	906	19939										
KRT6C	286887	broad.mit.edu	37	chr12	52865855	52865855	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaatggagtcctcacttgttCttgaggtcctccaccaggtc	9	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:52865855C>T	uc001sal.3	-	2	798	c.750G>A	c.(748-750)AAG>AAA	p.K250K		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	250	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		CTCACTTGTTCTTGAGGTCCT	0.547													0	0	0	1	0	28	97										T	52865855	C	T	52865855	2	4	65	1	0	0	0	0	0	0	0	1	8482	912	32	1		1	KRT6C	12	52865855	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1092515	52865855	80986040	907	19940										
PCBP2	5094	broad.mit.edu	37	chr12	53858606	53858606	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accaccccgtccatgtgcctCaaccctgacctggagggacc	9	18	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:53858606C>T	uc001sdl.3	+	9	1004	c.654C>T	c.(652-654)CTC>CTT	p.L218L	PCBP2_uc001sdc.3_Silent_p.L218L|PCBP2_uc001sdb.3_Silent_p.L214L|PCBP2_uc001sde.3_Silent_p.L214L|PCBP2_uc001sdi.3_Intron|PCBP2_uc001sdd.3_Intron|PCBP2_uc001sdf.3_Intron|PCBP2_uc009zna.2_Silent_p.L175L|PCBP2_uc010soi.1_Intron|PCBP2_uc001sdj.3_Intron|PCBP2_uc010soj.1_Intron|PCBP2_uc001sdk.3_Silent_p.L3L|PCBP2_uc010soh.1_Silent_p.L214L	NM_001128911	NP_001122383	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2 isoform d	218					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding				0						ccatgtgcctcaaccctgacc	0													0	0	0	1	0	20	60										T	53858606	C	T	53858606	2	4	65	1	0	0	0	0	0	0	0	1	11501	813	29	1		1	PCBP2	12	53858606	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	992751	53858606	79993289	908	19941										
GPR84	53831	broad.mit.edu	37	chr12	54756722	54756722	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgaagaatccggagctcttCtggctcctttaattggctgg	11	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:54756722C>T	uc001sfu.2	-	2	1004	c.914G>A	c.(913-915)AGA>AAA	p.R305K		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	305	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						CGGAGCTCTTCTGGCTCCTTT	0.507													0	0	0	1	0	50	147										T	54756722	C	T	54756722	3	4	65	1	0	0	0	0	1	0	0	0	6714	913	32	1	280	1	GPR84	12	54756722	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	898116	54756722	79095173	909	19942										
OR6C74	254783	broad.mit.edu	37	chr12	55641610	55641610	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcatttcttctgtgatgtttCtcctatactgcagctctctt	5	11	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:55641610C>G	uc010spg.1	+	1	539	c.539C>G	c.(538-540)TCT>TGT	p.S180C		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TGTGATGTTTCTCCTATACTG	0.433													0	0	0	1	0	20	79										G	55641610	C	G	55641610	3	3	65	1	0	0	0	0	1	0	0	0	11198	913	32	1	541	1	OR6C74	12	55641610	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	884888	55641610	78210285	910	19943										
SILV	6490	broad.mit.edu	37	chr12	56349424	56349424	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggggctggcaccctggcgatGagatctccatgcaggcttcc	14	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:56349424G>C	uc001sip.2	-	9	1617	c.1586C>G	c.(1585-1587)TCA>TGA	p.S529*	SILV_uc001siq.2_Nonsense_Mutation_p.S529*|SILV_uc010spx.1_Nonsense_Mutation_p.S443*|SILV_uc001sir.2_Nonsense_Mutation_p.S529*	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	529	Lumenal (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						CCCTGGCGATGAGATCTCCAT	0.597													0	0	0	1	0	16	86										C	56349424	G	C	56349424	4	2	65	1	0	0	0	0	0	1	0	0	14322	1294	45	1	411	1	SILV	12	56349424	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	707814	56349424	77502471	911	19944										
SILV	6490	broad.mit.edu	37	chr12	56349603	56349603	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagctcaaatgcatccccctCaccggacggcacagcctgca	8	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:56349603C>T	uc001sip.2	-	8	1547	c.1516G>A	c.(1516-1518)GAG>AAG	p.E506K	SILV_uc001siq.2_Missense_Mutation_p.E506K|SILV_uc010spx.1_Missense_Mutation_p.E420K|SILV_uc001sir.2_Missense_Mutation_p.E506K	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	506	Lumenal (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GCATCCCCCTCACCGGACGGC	0.537											OREG0021914	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	19	71										T	56349603	C	T	56349603	3	4	65	1	0	0	0	0	1	0	0	0	14322	835	29	1	485	1	SILV	12	56349603	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	179	56349603	77502292	912	19945										
PAN2	9924	broad.mit.edu	37	chr12	56722102	56722102	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacgagtagagtgctgctgtCagtcagtaggagactgtgca	14	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:56722102C>T	uc001skx.2	-	4	866	c.493G>A	c.(493-495)GAC>AAC	p.D165N	PAN2_uc001skz.2_Missense_Mutation_p.D165N|PAN2_uc001sky.2_Missense_Mutation_p.D165N	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	165					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GTGCTGCTGTCAGTCAGTAGG	0.512													0	0	0	1	0	50	130										T	56722102	C	T	56722102	3	4	65	1	0	0	0	0	1	0	0	0	11414	826	29	1	3207	1	PAN2	12	56722102	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	372499	56722102	77129793	913	19946										
HSD17B6	8630	broad.mit.edu	37	chr12	57181045	57181045	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggatgctaaatttttcttCatccctctatcttatttacc	4	10	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:57181045C>T	uc001smg.1	+	5	983	c.873C>T	c.(871-873)TTC>TTT	p.F291F		NM_003725	NP_003716	O14756	H17B6_HUMAN	hydroxysteroid (17-beta) dehydrogenase 6	291					androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			upper_aerodigestive_tract(1)|pancreas(1)	2					Succinic acid(DB00139)	AATTTTTCTTCATCCCTCTAT	0.473													0	0	0	1	0	11	46										T	57181045	C	T	57181045	2	4	65	1	0	0	0	0	0	0	0	1	7387	825	29	1		1	HSD17B6	12	57181045	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	458943	57181045	76670850	914	19947										
HELB	92797	broad.mit.edu	37	chr12	66718772	66718772	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttggtgacaggatgtaactGatgtaacttttggaaagaga	12	3	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:66718772G>A	uc001sti.2	+	11	2564	c.2536G>A	c.(2536-2538)GAT>AAT	p.D846N	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	846					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		GGATGTAACTGATGTAACTTT	0.328													0	0	0	1	0	18	56										A	66718772	G	A	66718772	3	1	65	1	0	0	0	0	1	0	0	0	7045	1290	45	1	2578	1	HELB	12	66718772	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9537727	66718772	67133123	915	19948										
NAV3	89795	broad.mit.edu	37	chr12	78569172	78569172	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagtattggcagtggtaatGatgccgactccaagaagaag	12	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:78569172G>C	uc001syp.2	+	25	5241	c.5068G>C	c.(5068-5070)GAT>CAT	p.D1690H	NAV3_uc001syo.2_Missense_Mutation_p.D1690H|NAV3_uc010sub.1_Missense_Mutation_p.D1176H|NAV3_uc009zsf.2_Missense_Mutation_p.D521H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1690						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAGTGGTAATGATGCCGACTC	0.398										HNSCC(70;0.22)			0	0	0	1	0	6	46										C	78569172	G	C	78569172	3	2	65	1	0	0	0	0	1	0	0	0	10185	1290	45	1	5166	1	NAV3	12	78569172	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11850400	78569172	55282723	916	19949										
MGAT4C	25834	broad.mit.edu	37	chr12	86373294	86373294	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggctccatgatgcaaaatatCattttgccgatcttctgttc	7	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:86373294C>G	uc001tai.3	-	8	2460	c.1210G>C	c.(1210-1212)GAT>CAT	p.D404H	MGAT4C_uc001tal.3_Missense_Mutation_p.D404H|MGAT4C_uc001taj.3_Missense_Mutation_p.D404H|MGAT4C_uc001tak.3_Missense_Mutation_p.D404H|MGAT4C_uc010sum.1_Missense_Mutation_p.D428H|MGAT4C_uc001tah.3_Missense_Mutation_p.D404H	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	404	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TGCAAAATATCATTTTGCCGA	0.328													0	0	0	1	0	14	28										G	86373294	C	G	86373294	3	3	65	1	0	0	0	0	1	0	0	0	9547	826	29	1	230	1	MGAT4C	12	86373294	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7804122	86373294	47478601	917	19950										
C12orf63	374467	broad.mit.edu	37	chr12	97157951	97157951	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctctcagaagaagtagttCtgttaaagaaacatcagcaa	7	8	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:97157951C>T	uc001tet.1	+	26	3416	c.3338C>T	c.(3337-3339)TCT>TTT	p.S1113F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1113										skin(6)|ovary(1)	7						AGAAGTAGTTCTGTTAAAGAA	0.328													0	0	0	1	0	4	22										T	97157951	C	T	97157951	3	4	65	1	0	0	0	0	1	0	0	0	1706	913	32	1	3436	1	C12orf63	12	97157951	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	10784657	97157951	36693944	918	19951										
ACTR6	64431	broad.mit.edu	37	chr12	100612202	100612202	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgtctttaagccaagggaaGagatggtgttgagtggaaaa	14	3	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:100612202G>A	uc001thb.1	+	9	816	c.760G>A	c.(760-762)GAG>AAG	p.E254K	ACTR6_uc001thc.1_Missense_Mutation_p.E146K|ACTR6_uc001thd.1_Missense_Mutation_p.E254K|ACTR6_uc009ztu.1_Missense_Mutation_p.E59K|ACTR6_uc001the.1_Missense_Mutation_p.E172K|ACTR6_uc001thf.1_Missense_Mutation_p.E172K|uc001thg.1_Intron	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	254						cytoplasm|cytoskeleton				ovary(1)	1						GCCAAGGGAAGAGATGGTGTT	0.294													0	0	0	1	0	7	55										A	100612202	G	A	100612202	3	1	65	1	0	0	0	0	1	0	0	0	216	943	33	1	794	1	ACTR6	12	100612202	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3454251	100612202	33239693	919	19952										
UTP20	27340	broad.mit.edu	37	chr12	101684562	101684562	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagtcactgaaacagaaactCaactaccatggatgttaatt	6	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:101684562C>G	uc001tia.1	+	8	943	c.787C>G	c.(787-789)CAA>GAA	p.Q263E	UTP20_uc009ztz.1_Missense_Mutation_p.Q263E	NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	263					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AACAGAAACTCAACTACCATG	0.343													0	0	0	1	0	17	58										G	101684562	C	G	101684562	3	3	65	1	0	0	0	0	1	0	0	0	17096	827	29	1	817	1	UTP20	12	101684562	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1072360	101684562	32167333	920	19953										
TDG	6996	broad.mit.edu	37	chr12	104377149	104377149	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttgggcttcagccccataaGattccagacacagaaactgt	8	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:104377149G>C	uc001tkg.2	+	7	997	c.774G>C	c.(772-774)AAG>AAC	p.K258N	TDG_uc009zuk.2_Missense_Mutation_p.K254N|TDG_uc010swi.1_Missense_Mutation_p.K115N|TDG_uc010swj.1_Missense_Mutation_p.K46N	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	258					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		AGCCCCATAAGATTCCAGACA	0.289								BER_DNA_glycosylases					0	0	0	1	0	7	49										C	104377149	G	C	104377149	3	2	65	1	0	0	0	0	1	0	0	0	15722	933	33	1	800	1	TDG	12	104377149	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2692587	104377149	29474746	921	19954										
TXNRD1	7296	broad.mit.edu	37	chr12	104719163	104719163	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccgactcagagtagtagctCagtccaccaatagtgaggaa	11	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:104719163C>T	uc010swk.1	+	11	1286	c.1264C>T	c.(1264-1266)CAG>TAG	p.Q422*	TXNRD1_uc010swl.1_Nonsense_Mutation_p.Q272*|TXNRD1_uc010swm.1_Nonsense_Mutation_p.Q324*|TXNRD1_uc010swn.1_Nonsense_Mutation_p.Q272*|TXNRD1_uc010swo.1_Nonsense_Mutation_p.Q272*|TXNRD1_uc010swp.1_Nonsense_Mutation_p.Q234*|TXNRD1_uc010swq.1_Nonsense_Mutation_p.Q322*|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Nonsense_Mutation_p.Q338*	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	422					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						AGTAGTAGCTCAGTCCACCAA	0.383													0	0	0	1	0	4	16										T	104719163	C	T	104719163	4	4	65	1	0	0	0	0	0	1	0	0	16804	827	29	1	1320	1	TXNRD1	12	104719163	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	342014	104719163	29132732	922	19955										
TCP11L2	255394	broad.mit.edu	37	chr12	106729964	106729964	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggttaacaaggatttcagCtgttctacttgaaggcatga	10	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:106729964C>G	uc001tln.2	+	8	1289	c.1115C>G	c.(1114-1116)GCT>GGT	p.A372G		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	372										ovary(3)	3						AGGATTTCAGCTGTTCTACTT	0.433													0	0	0	1	0	14	46										G	106729964	C	G	106729964	3	3	65	1	0	0	0	0	1	0	0	0	15712	797	28	4	1141	4	TCP11L2	12	106729964	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2010801	106729964	27121931	923	19956										
POLR3B	55703	broad.mit.edu	37	chr12	106770206	106770206	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagcagaatttgccaaactGaacgaatgtcccttagatcc	7	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:106770206G>C	uc001tlp.2	+	7	696	c.474G>C	c.(472-474)CTG>CTC	p.L158L	POLR3B_uc001tlq.2_Silent_p.L100L	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	158					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTGCCAAACTGAACGAATGTC	0.368													0	0	0	1	0	15	59										C	106770206	G	C	106770206	2	2	65	1	0	0	0	0	0	0	0	1	12229	1277	45	1		1	POLR3B	12	106770206	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	40242	106770206	27081689	924	19957										
VPS29	51699	broad.mit.edu	37	chr12	110933819	110933819	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaagggaaatacatcacctCatcgaagtctcctctcacaa	6	12	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:110933819C>T	uc001tqy.2	-	2	253	c.193G>A	c.(193-195)GAG>AAG	p.E65K	VPS29_uc001tqw.2_RNA|VPS29_uc001tqx.2_Missense_Mutation_p.E69K|VPS29_uc001tqz.2_RNA	NM_016226	NP_057310	Q9UBQ0	VPS29_HUMAN	vacuolar protein sorting 29 isoform 1	65					protein transport	endosome membrane	metal ion binding|phosphoserine phosphatase activity				0						TACATCACCTCATCGAAGTCT	0.403													0	0	0	1	0	24	50										T	110933819	C	T	110933819	3	4	65	1	0	0	0	0	1	0	0	0	17197	835	29	1	367	1	VPS29	12	110933819	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4163613	110933819	22918076	925	19958										
FAM109A	144717	broad.mit.edu	37	chr12	111801049	111801049	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acagtgcagccctccaggatGatgacgcccacgggctcacg	12	15	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:111801049G>C	uc001tsd.3	-	3	574	c.183C>G	c.(181-183)ATC>ATG	p.I61M	FAM109A_uc009zvu.2_Nonsense_Mutation_p.S42*|FAM109A_uc001tsc.2_Missense_Mutation_p.I84M	NM_144671	NP_653272	Q8N4B1	SESQ1_HUMAN	hypothetical protein LOC144717	61	PH.				endosome organization|receptor recycling|retrograde transport, endosome to Golgi	clathrin-coated vesicle|early endosome|recycling endosome|trans-Golgi network	protein homodimerization activity				0						CCTCCAGGATGATGACGCCCA	0.701													0	0	0	1	0	13	49										C	111801049	G	C	111801049	3	2	65	1	0	0	0	0	1	0	0	0	5394	1280	45	1	570	1	FAM109A	12	111801049	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	867230	111801049	22050846	926	19959										
RPH3A	22895	broad.mit.edu	37	chr12	113304639	113304639	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcaaaatctgcattgagcaGagggaggtgagtgccctggt	15	7	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:113304639G>A	uc010syl.1	+	7	800	c.438G>A	c.(436-438)CAG>CAA	p.Q146Q	RPH3A_uc001ttz.2_Silent_p.Q146Q|RPH3A_uc001tty.2_Silent_p.Q142Q|RPH3A_uc009zwe.1_Silent_p.Q142Q|RPH3A_uc010sym.1_Silent_p.Q97Q|RPH3A_uc001tua.2_5'Flank	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	146	RabBD.|FYVE-type.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCATTGAGCAGAGGGAGGTGA	0.537													0	0	0	1	0	9	17										A	113304639	G	A	113304639	2	1	65	1	0	0	0	0	0	0	0	1	13551	933	33	1		1	RPH3A	12	113304639	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1503590	113304639	20547256	927	19960										
DDX54	79039	broad.mit.edu	37	chr12	113599704	113599704	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcccctcaggatacaggtctCgcttgtaggagctgctgatg	13	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:113599704C>T	uc001tup.2	-	18	2322	c.2294G>A	c.(2293-2295)CGA>CAA	p.R765Q	DDX54_uc001tuq.3_Missense_Mutation_p.R765Q	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	765					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						ATACAGGTCTCGCTTGTAGGA	0.517													0	0	0	1	0	41	183										T	113599704	C	T	113599704	3	4	65	1	0	0	0	0	1	0	0	0	4372	884	31	1	366	1	DDX54	12	113599704	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	295065	113599704	20252191	928	19961										
GCN1L1	10985	broad.mit.edu	37	chr12	120575013	120575013	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acgaggccctggcttaccttCttcgggaggcagaatcctgg	13	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:120575013C>T	uc001txo.2	-	50	6787	c.6774G>A	c.(6772-6774)AAG>AAA	p.K2258K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2258					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCTTACCTTCTTCGGGAGGC	0.607													0	0	0	1	0	32	104										T	120575013	C	T	120575013	2	4	65	1	0	0	0	0	0	0	0	1	6299	912	32	1		1	GCN1L1	12	120575013	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6975309	120575013	13276882	929	19962										
SFRS9	8683	broad.mit.edu	37	chr12	120907289	120907289	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccggttcttgagctcgatctCgcggatgcggccgtacttgt	13	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:120907289C>T	uc001tyi.2	-	1	270	c.124G>A	c.(124-126)GAG>AAG	p.E42K	SFRS9_uc009zwy.2_Missense_Mutation_p.E42K|DYNLL1_uc001tyj.2_5'Flank	NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9	42	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCTCGATCTCGCGGATGCGG	0.493													0	0	0	1	0	18	57										T	120907289	C	T	120907289	3	4	65	1	0	0	0	0	1	0	0	0	14184	893	31	1	557	1	SFRS9	12	120907289	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	332276	120907289	12944606	930	19963										
RNF10	9921	broad.mit.edu	37	chr12	121002980	121002980	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtctctaaggaaaccctaGagatgttctcaggtgagaat	11	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:121002980G>C	uc001typ.3	+	11	2254	c.1771G>C	c.(1771-1773)GAG>CAG	p.E591Q	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.E502Q	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	591					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGAAACCCTAGAGATGTTCTC	0.428													0	0	0	1	0	31	84										C	121002980	G	C	121002980	3	2	65	1	0	0	0	0	1	0	0	0	13422	943	33	1	1813	1	RNF10	12	121002980	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	95691	121002980	12848915	931	19964										
CABP1	9478	broad.mit.edu	37	chr12	121098025	121098025	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagaggccttcagagaattcGacaaggacaaggatggctac	13	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:121098025G>C	uc001tyu.2	+	3	779	c.712G>C	c.(712-714)GAC>CAC	p.D238H	CABP1_uc001tyv.2_Missense_Mutation_p.D95H|CABP1_uc001tyw.2_Missense_Mutation_p.D35H|CABP1_uc001tyx.2_Missense_Mutation_p.D80H	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	238	1.|EF-hand 1.	Magnesium.		D->A: Loss of magnesium-binding. Loss of binding to ITPRs; when associated with A- 240; A-315; A-317; A-352 and A-354.		cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAGAGAATTCGACAAGGACAA	0.582													0	0	0	1	0	27	76										C	121098025	G	C	121098025	3	2	65	1	0	0	0	0	1	0	0	0	2531	1058	37	1	955	1	CABP1	12	121098025	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	95045	121098025	12753870	932	19965										
MLEC	9761	broad.mit.edu	37	chr12	121132759	121132759	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaagctgagtgtccaggggGaggtgtccaccttcacaggg	17	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:121132759G>A	uc001tyy.1	+	3	698	c.547G>A	c.(547-549)GAG>AAG	p.E183K		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	183	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						TGTCCAGGGGGAGGTGTCCAC	0.478													0	0	0	1	0	47	121										A	121132759	G	A	121132759	3	1	65	1	0	0	0	0	1	0	0	0	9613	1175	41	1	557	1	MLEC	12	121132759	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	34734	121132759	12719136	933	19966										
OASL	8638	broad.mit.edu	37	chr12	121465473	121465473	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatacagatgacttcatactCcaggagcaggtccatcacag	9	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:121465473C>T	uc001tzj.1	-	4	811	c.805G>A	c.(805-807)GAG>AAG	p.E269K	OASL_uc001tzk.1_Intron	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	269					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACTTCATACTCCAGGAGCAGG	0.438													0	0	0	1	0	34	63										T	121465473	C	T	121465473	3	4	65	1	0	0	0	0	1	0	0	0	10802	864	30	1	751	1	OASL	12	121465473	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	332714	121465473	12386422	934	19967										
ANAPC5	51433	broad.mit.edu	37	chr12	121757561	121757561	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacaagtgaatcagccaaatGatatttgccatcattcattg	6	8	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:121757561G>A	uc001uag.2	-	13	1698	c.1576C>T	c.(1576-1578)CAT>TAT	p.H526Y	ANAPC5_uc010szu.1_Missense_Mutation_p.H192Y|ANAPC5_uc001uae.2_Missense_Mutation_p.H90Y|ANAPC5_uc010szv.1_Missense_Mutation_p.H128Y|ANAPC5_uc001uaf.2_RNA|ANAPC5_uc001uah.2_Missense_Mutation_p.H414Y|ANAPC5_uc001uai.1_Missense_Mutation_p.H128Y	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	anaphase-promoting complex subunit 5 isoform a	526	TPR 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			skin(3)|breast(2)|kidney(1)	6	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCAGCCAAATGATATTTGCCA	0.333													0	0	0	1	0	9	16										A	121757561	G	A	121757561	3	1	65	1	0	0	0	0	1	0	0	0	605	1290	45	1	711	1	ANAPC5	12	121757561	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	292088	121757561	12094334	935	19968										
WDR66	144406	broad.mit.edu	37	chr12	122441644	122441644	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcttggcttaaccatttcaGaagattccggccaggatggt	10	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:122441644G>A	uc009zxk.2	+	22	3566	c.3424G>A	c.(3424-3426)GAA>AAA	p.E1142K		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1142							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		AACCATTTCAGAAGATTCCGG	0.433													0	0	0	1	0	16	58										A	122441644	G	A	122441644	3	1	65	1	0	0	0	0	1	0	0	0	17314	943	33	1	3565	1	WDR66	12	122441644	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	684083	122441644	11410251	936	19969										
ZCCHC8	55596	broad.mit.edu	37	chr12	122983381	122983381	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaaaatctcatacctcggtcGagtcagaatgttcaattttc	6	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:122983381G>C	uc001ucn.2	-	2	366	c.235C>G	c.(235-237)CGA>GGA	p.R79G	ZCCHC8_uc009zxp.2_5'UTR|ZCCHC8_uc009zxq.2_5'UTR	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	79	Potential.					catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		TACCTCGGTCGAGTCAGAATG	0.294													0	0	0	1	0	5	14										C	122983381	G	C	122983381	3	2	65	1	0	0	0	0	1	0	0	0	17591	1066	37	1	1940	1	ZCCHC8	12	122983381	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	541737	122983381	10868514	937	19970										
ABCB9	23457	broad.mit.edu	37	chr12	123424766	123424766	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggatgttgacacaggagctCttcccactgcccgagggccc	12	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:123424766C>T	uc001udm.3	-	9	1945	c.1635G>A	c.(1633-1635)AAG>AAA	p.K545K	ABCB9_uc010tai.1_Silent_p.K152K|ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Silent_p.K502K|ABCB9_uc010taj.1_Silent_p.K482K|ABCB9_uc001udp.2_Silent_p.K545K|ABCB9_uc001udq.2_Silent_p.K264K|ABCB9_uc001udr.2_Silent_p.K545K	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	545	ABC transporter.|ATP (Potential).				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CACAGGAGCTCTTCCCACTGC	0.627													0	0	0	1	0	11	48										T	123424766	C	T	123424766	2	4	65	1	0	0	0	0	0	0	0	1	48	912	32	1		1	ABCB9	12	123424766	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	441385	123424766	10427129	938	19971										
SBNO1	55206	broad.mit.edu	37	chr12	123821011	123821011	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcatcttcttcctctggttCatcatcttcttttacaacag	3	12	8	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:123821011C>T	uc010tap.1	-	5	679	c.679G>A	c.(679-681)GAA>AAA	p.E227K	SBNO1_uc010tao.1_Missense_Mutation_p.E226K|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.E227K|SBNO1_uc001ueu.2_Missense_Mutation_p.E226K|SBNO1_uc001uev.2_Missense_Mutation_p.E225K|SBNO1_uc009zxy.1_Missense_Mutation_p.E192K	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	227							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		tcctctggttcatcatcttct	0.343													0	0	0	1	0	5	28										T	123821011	C	T	123821011	3	4	65	1	0	0	0	0	1	0	0	0	13862	835	29	1	3610	1	SBNO1	12	123821011	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	396245	123821011	10030884	939	19972										
SETD8	387893	broad.mit.edu	37	chr12	123889520	123889520	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggaataccacggggacctCatcgagatcaccgacgccaa	11	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:123889520C>T	uc001uew.2	+	7	789	c.747C>T	c.(745-747)CTC>CTT	p.L249L	SETD8_uc001uex.2_Silent_p.L184L	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	290	SET.				cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		ACGGGGACCTCATCGAGATCA	0.537													0	0	0	1	0	17	65										T	123889520	C	T	123889520	2	4	65	1	0	0	0	0	0	0	0	1	14137	813	29	1		1	SETD8	12	123889520	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	68509	123889520	9962375	940	19973										
DNAH10	196385	broad.mit.edu	37	chr12	124293452	124293452	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catcccaacacaaatgagatCgacaagatgtgcttccattg	7	11	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:124293452C>T	uc001uft.3	+	18	2767	c.2742C>T	c.(2740-2742)ATC>ATT	p.I914I	DNAH10_uc010tav.1_Silent_p.I456I|DNAH10_uc010taw.1_Silent_p.I399I	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	914	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAAATGAGATCGACAAGATGT	0.468													0	0	0	1	0	78	266										T	124293452	C	T	124293452	2	4	65	1	0	0	0	0	0	0	0	1	4598	874	31	1		1	DNAH10	12	124293452	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	403932	124293452	9558443	941	19974										
EP400	57634	broad.mit.edu	37	chr12	132502203	132502203	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccaggctcttcctacgtggcGgggccactggagtatccgtc	13	14	1	0	rs141645142		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr12:132502203G>A	uc001ujn.2	+	19	4082	c.4047G>A	c.(4045-4047)GCG>GCA	p.A1349A	EP400_uc001ujl.2_Silent_p.A1348A|EP400_uc001ujm.2_Silent_p.A1349A	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1385					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCTACGTGGCGGGGCCACTGG	0.582													0	0	0	1	0	22	77										A	132502203	G	A	132502203	2	1	65	1	0	0	0	0	0	0	0	1	5149	1103	39	2		2	EP400	12	132502203	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8208751	132502203	1349692	942	19975										
TUBA3C	7278	broad.mit.edu	37	chr13	19748188	19748188	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcgaacttatggtccaggcGagcccaggcctccgcgatgg	13	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:19748188G>A	uc009zzj.2	-	5	1217	c.1168C>T	c.(1168-1170)CGC>TGC	p.R390C		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	390					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGGTCCAGGCGAGCCCAGGCC	0.647													0	0	0	1	0	44	175										A	19748188	G	A	19748188	3	1	65	1	0	0	0	0	1	0	0	0	16743	1058	37	1	188	1	TUBA3C	13	19748188	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		19748188	95421690	943	19976										
ZMYM5	9205	broad.mit.edu	37	chr13	20413042	20413042	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggctggaaattctgcttacGaagtaaggccactggtgata	12	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:20413042G>A	uc010tcn.1	-	5	935	c.670C>T	c.(670-672)CGT>TGT	p.R224C	ZMYM5_uc001umm.1_Missense_Mutation_p.R48C|ZMYM5_uc001umn.2_Missense_Mutation_p.R224C|ZMYM5_uc001umo.2_Intron	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	224						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TTCTGCTTACGAAGTAAGGCC	0.423													0	0	0	1	0	48	123										A	20413042	G	A	20413042	3	1	65	1	0	0	0	0	1	0	0	0	17700	1058	37	1	1466	1	ZMYM5	13	20413042	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	664854	20413042	94756836	944	19977										
N6AMT2	221143	broad.mit.edu	37	chr13	21331662	21331662	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcaatttgttgcttttgctCagcataaaattcctggagag	8	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:21331662C>G	uc001uno.1	-	2	157	c.76G>C	c.(76-78)GAG>CAG	p.E26Q	N6AMT2_uc009zzr.1_Missense_Mutation_p.E26Q|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	26							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		TGCTTTTGCTCAGCATAAAAT	0.408													0	0	0	1	0	21	59										G	21331662	C	G	21331662	3	3	65	1	0	0	0	0	1	0	0	0	10115	835	29	1	584	1	N6AMT2	13	21331662	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	918620	21331662	93838216	945	19978										
SACS	26278	broad.mit.edu	37	chr13	23913064	23913064	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actcacttttgcttcctgttGagttctaaaggacagtcgga	9	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:23913064G>C	uc001uon.2	-	10	5540	c.4951C>G	c.(4951-4953)CAA>GAA	p.Q1651E	SACS_uc001uoo.2_Missense_Mutation_p.Q1504E|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1651					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCTTCCTGTTGAGTTCTAAAG	0.388													0	0	0	1	0	13	50										C	23913064	G	C	23913064	3	2	65	1	0	0	0	0	1	0	0	0	13804	1299	45	1	8792	1	SACS	13	23913064	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2581402	23913064	91256814	946	19979										
GSX1	219409	broad.mit.edu	37	chr13	28367224	28367224	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcctgaccccaggcagttcCactgcatctctgtgggtaag	11	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:28367224C>T	uc001urr.1	+	1	445	c.397C>T	c.(397-399)CAC>TAC	p.H133Y		NM_145657	NP_663632	Q9H4S2	GSX1_HUMAN	GS homeobox 1	133					positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CAGGCAGTTCCACTGCATCTC	0.697													0	0	0	1	0	6	23										T	28367224	C	T	28367224	3	4	65	1	0	0	0	0	1	0	0	0	6849	594	21	2	399	2	GSX1	13	28367224	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4454160	28367224	86802654	947	19980										
CSNK1A1L	122011	broad.mit.edu	37	chr13	37678589	37678589	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catgtaatctgggacttcctCaaagcgcagcccacgacagt	9	13	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:37678589C>G	uc001uwm.1	-	1	1213	c.805G>C	c.(805-807)GAG>CAG	p.E269Q		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	269	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		GGGACTTCCTCAAAGCGCAGC	0.443													0	0	0	1	0	38	112										G	37678589	C	G	37678589	3	3	65	1	0	0	0	0	1	0	0	0	3951	835	29	1	212	1	CSNK1A1L	13	37678589	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	9311365	37678589	77491289	948	19981										
KIAA0564	23078	broad.mit.edu	37	chr13	42335283	42335283	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctgtgtagctgaatatattCtcggggtctgttgagcaggt	13	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:42335283C>G	uc001uyj.2	-	21	2477	c.2407G>C	c.(2407-2409)GAA>CAA	p.E803Q	KIAA0564_uc001uyk.2_Missense_Mutation_p.E803Q	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	803						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TGAATATATTCTCGGGGTCTG	0.348													0	0	0	1	0	17	84										G	42335283	C	G	42335283	3	3	65	1	0	0	0	0	1	0	0	0	8185	922	32	1	3414	1	KIAA0564	13	42335283	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4656694	42335283	72834595	949	19982										
TPT1	7178	broad.mit.edu	37	chr13	45912831	45912831	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaaccatccttaaagaaaatCatatatggggtcacaccatc	5	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:45912831C>T	uc001uzy.1	-	5	573	c.480G>A	c.(478-480)ATG>ATA	p.M160I	TPT1_uc001uzz.1_Missense_Mutation_p.M126I|SNORA31_uc001vaa.1_5'Flank|LOC100190939_uc010tfr.1_5'Flank|LOC100190939_uc001vac.2_5'Flank	NM_003295	NP_003286	P13693	TCTP_HUMAN	tumor protein, translationally-controlled 1	160					anti-apoptosis|response to virus	extracellular space|multivesicular body	calcium ion binding|protein binding				0		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000232)		TAAAGAAAATCATATATGGGG	0.338													0	0	0	1	0	15	42										T	45912831	C	T	45912831	3	4	65	1	0	0	0	0	1	0	0	0	16426	826	29	1	46	1	TPT1	13	45912831	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3577548	45912831	69257047	950	19983										
TPT1	7178	broad.mit.edu	37	chr13	45914250	45914250	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctttcggtaccttcgccctCggggccttcagcggaggcat	13	14	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:45914250C>G	uc001uzy.1	-	3	265	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	TPT1_uc001uzz.1_Missense_Mutation_p.E24Q|SNORA31_uc001vaa.1_5'Flank|TPT1_uc010tfp.1_3'UTR|LOC100190939_uc010tfr.1_5'Flank|LOC100190939_uc001vac.2_5'Flank	NM_003295	NP_003286	P13693	TCTP_HUMAN	tumor protein, translationally-controlled 1	58					anti-apoptosis|response to virus	extracellular space|multivesicular body	calcium ion binding|protein binding				0		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000232)		CCTTCGCCCTCGGGGCCTTCA	0.448													0	0	0	1	0	22	81										G	45914250	C	G	45914250	3	3	65	1	0	0	0	0	1	0	0	0	16426	893	31	1	362	1	TPT1	13	45914250	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1419	45914250	69255628	951	19984										
CPB2	1361	broad.mit.edu	37	chr13	46658451	46658451	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttttcttcacaataaggtCagctgttaccggctgccaga	8	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:46658451C>T	uc001vaw.2	-	3	245	c.178G>A	c.(178-180)GAC>AAC	p.D60N	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Missense_Mutation_p.D60N	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	60					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		ACAATAAGGTCAGCTGTTACC	0.378													0	0	0	1	0	24	53										T	46658451	C	T	46658451	3	4	65	1	0	0	0	0	1	0	0	0	3797	826	29	1	1129	1	CPB2	13	46658451	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	744201	46658451	68511427	952	19985										
ESD	2098	broad.mit.edu	37	chr13	47356852	47356852	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gttggttttccaaggatcttCagtggcatcaacataaaatc	8	8	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:47356852C>T	uc001vbn.2	-	6	514	c.331G>A	c.(331-333)GAA>AAA	p.E111K	ESD_uc001vbo.2_Missense_Mutation_p.E111K|ESD_uc001vbp.1_5'Flank	NM_001984	NP_001975	P10768	ESTD_HUMAN	esterase D/formylglutathione hydrolase	111						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			ovary(1)	1		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	CAAGGATCTTCAGTGGCATCA	0.378													0	0	0	1	0	18	75										T	47356852	C	T	47356852	3	4	65	1	0	0	0	0	1	0	0	0	5250	835	29	1	537	1	ESD	13	47356852	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	698401	47356852	67813026	953	19986										
FNDC3A	22862	broad.mit.edu	37	chr13	49710506	49710506	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaggtccaactttagagatGaacgatctagtaaaacatat	8	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:49710506G>C	uc001vcm.2	+	6	834	c.529G>C	c.(529-531)GAA>CAA	p.E177Q	FNDC3A_uc001vcl.1_Missense_Mutation_p.E177Q|FNDC3A_uc001vcn.2_Missense_Mutation_p.E177Q|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.E121Q|FNDC3A_uc001vcq.2_Missense_Mutation_p.E121Q	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	177						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CTTTAGAGATGAACGATCTAG	0.378													0	0	0	1	0	12	40										C	49710506	G	C	49710506	3	2	65	1	0	0	0	0	1	0	0	0	5969	1291	45	1	558	1	FNDC3A	13	49710506	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2353654	49710506	65459372	954	19987										
KCNRG	283518	broad.mit.edu	37	chr13	50590174	50590174	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctggttttccagtgtggttCtgacagcactactgataacc	9	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:50590174C>G	uc001vdu.2	+	1	785	c.545C>G	c.(544-546)TCT>TGT	p.S182C	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_Missense_Mutation_p.S182C|TRIM13_uc001vdp.1_3'UTR|TRIM13_uc001vdq.1_3'UTR|TRIM13_uc001vdr.1_3'UTR|TRIM13_uc001vds.1_3'UTR	NM_173605	NP_775876	Q8N5I3	KCNRG_HUMAN	potassium channel regulator isoform 1	182						voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		CAGTGTGGTTCTGACAGCACT	0.428													0	0	0	1	0	14	47										G	50590174	C	G	50590174	3	3	65	1	0	0	0	0	1	0	0	0	8087	913	32	1	547	1	KCNRG	13	50590174	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	879668	50590174	64579704	955	19988										
PCDH17	27253	broad.mit.edu	37	chr13	58207697	58207697	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcccactgcaaagtcacggtCaagctcatcgaccgcaacga	9	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:58207697C>G	uc001vhq.1	+	1	1909	c.1017C>G	c.(1015-1017)GTC>GTG	p.V339V	PCDH17_uc010aec.1_Silent_p.V339V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	339	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AAGTCACGGTCAAGCTCATCG	0.642													0	0	0	1	0	42	108										G	58207697	C	G	58207697	2	3	65	1	0	0	0	0	0	0	0	1	11512	813	29	1		1	PCDH17	13	58207697	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7617523	58207697	56962181	956	19989										
DIAPH3	81624	broad.mit.edu	37	chr13	60584692	60584692	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcttcccctacaatgcataCcgcagagagaagtttaacca	6	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:60584692C>A	uc001vht.2	-	8	1102	c.883G>T	c.(883-885)GTA>TTA	p.V295L	DIAPH3_uc001vhu.2_Missense_Mutation_p.V32L|DIAPH3_uc001vhw.1_Missense_Mutation_p.V284L|DIAPH3_uc010aed.1_Missense_Mutation_p.V249L|DIAPH3_uc010aee.1_Missense_Mutation_p.V225L|uc001vhx.2_5'Flank|uc001vhy.2_5'Flank	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	295	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		ACAATGCATACCGCAGAGAGA	0.368													1	0	0.150653	1	0.15101	4	16										A	60584692	C	A	60584692	3	1	65	1	0	0	0	0	1	0	0	0	4520	507	18	4	2802	4	DIAPH3	13	60584692	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2376995	60584692	54585186	957	19990										
KLHL1	57626	broad.mit.edu	37	chr13	70681477	70681477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagtgactccacgtagaagaGagtcctggctggctgctgag	14	9	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:70681477G>A	uc001vip.2	-	1	1149	c.355C>T	c.(355-357)CTC>TTC	p.L119F	KLHL1_uc010thm.1_Missense_Mutation_p.L119F|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	119					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		ACGTAGAAGAGAGTCCTGGCT	0.562													0	0	0	1	0	29	75										A	70681477	G	A	70681477	3	1	65	1	0	0	0	0	1	0	0	0	8365	942	33	1	1935	1	KLHL1	13	70681477	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	10096785	70681477	44488401	958	19991										
C13orf34	79866	broad.mit.edu	37	chr13	73321094	73321094	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgatcctatagagatagcaGatgagaccacttggattaag	10	6	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:73321094G>C	uc001viv.1	+	10	1446	c.1327G>C	c.(1327-1329)GAT>CAT	p.D443H	C13orf34_uc010thq.1_Missense_Mutation_p.D218H|C13orf34_uc010aen.1_Missense_Mutation_p.D518H|C13orf34_uc010thr.1_Missense_Mutation_p.D373H|C13orf34_uc001viw.1_Missense_Mutation_p.D392H	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	443					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		AGAGATAGCAGATGAGACCAC	0.413													0	0	0	1	0	24	87										C	73321094	G	C	73321094	3	2	65	1	0	0	0	0	1	0	0	0	1728	942	33	1	1361	1	C13orf34	13	73321094	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2639617	73321094	41848784	959	19992										
LMO7	4008	broad.mit.edu	37	chr13	76408454	76408454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ataacgattcaaaagagtggGaggaagccatggctaaggct	13	6	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:76408454G>A	uc001vjv.2	+	14	3218	c.2458G>A	c.(2458-2460)GAG>AAG	p.E820K	LMO7_uc010thv.1_Missense_Mutation_p.E771K|LMO7_uc001vjt.1_Missense_Mutation_p.E719K|LMO7_uc010thw.1_Missense_Mutation_p.E670K|LMO7_uc001vjw.1_Missense_Mutation_p.E726K	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1105	PDZ.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AAAAGAGTGGGAGGAAGCCAT	0.418													0	0	0	1	0	29	71										A	76408454	G	A	76408454	3	1	65	1	0	0	0	0	1	0	0	0	8855	1175	41	1	3383	1	LMO7	13	76408454	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3087360	76408454	38761424	960	19993										
MYCBP2	23077	broad.mit.edu	37	chr13	77736073	77736073	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcctcaagaatttcaaggtCttcttctaattcattacctg	4	11	6	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:77736073C>G	uc001vkf.2	-	45	6542	c.6451G>C	c.(6451-6453)GAC>CAC	p.D2151H	MYCBP2_uc010aev.2_Missense_Mutation_p.D1555H	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATTTCAAGGTCTTCTTCTAAT	0.294													0	0	0	1	0	11	60										G	77736073	C	G	77736073	3	3	65	1	0	0	0	0	1	0	0	0	10018	913	32	1	7631	1	MYCBP2	13	77736073	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1327619	77736073	37433805	961	19994										
FARP1	10160	broad.mit.edu	37	chr13	99037049	99037049	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaaaaataaatacatacctCagcaagacgcactagaggac	6	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:99037049C>T	uc001vnj.2	+	7	898	c.562C>T	c.(562-564)CAG>TAG	p.Q188*	FARP1_uc001vnh.2_Nonsense_Mutation_p.Q188*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	188	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			ATACATACCTCAGCAAGACGC	0.418													0	0	0	1	0	8	37										T	99037049	C	T	99037049	4	4	65	1	0	0	0	0	0	1	0	0	5676	827	29	1	807	1	FARP1	13	99037049	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	21300976	99037049	16132829	962	19995										
DOCK9	23348	broad.mit.edu	37	chr13	99520266	99520266	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccatgaaggtgaaacatctCtgtggaggaaaacaagcaaa	10	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:99520266C>A	uc001vnt.2	-	29	3149	c.3094_splice	c.e29-1	p.R1032_splice	DOCK9_uc001vnw.2_Splice_Site_p.R1031_splice|DOCK9_uc001vnv.1_Splice_Site|DOCK9_uc010tir.1_Splice_Site_p.R1032_splice|DOCK9_uc010tis.1_Splice_Site_p.R1031_splice|DOCK9_uc010tit.1_Splice_Site_p.R1032_splice|DOCK9_uc010tiq.1_Splice_Site|DOCK9_uc010afu.1_Splice_Site_p.R878_splice	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGAAACATCTCTGTGGAGGAA	0.408													1	0	0.0215528	1	0.0216679	4	19										A	99520266	C	A	99520266	5	1	65	1	0	0	0	0	0	0	1	0	4694	927	32	3	3289	3	DOCK9	13	99520266	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	483217	99520266	15649612	963	19996										
TM9SF2	9375	broad.mit.edu	37	chr13	100181787	100181787	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cataccatacagagaaagctGaagacaaacaaaagttagaa	7	7	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:100181787G>A	uc001voj.1	+	4	533	c.400G>A	c.(400-402)GAA>AAA	p.E134K	TM9SF2_uc010afz.1_Intron	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	134	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					AGAGAAAGCTGAAGACAAACA	0.313													0	0	0	1	0	22	31										A	100181787	G	A	100181787	3	1	65	1	0	0	0	0	1	0	0	0	15975	1291	45	1	414	1	TM9SF2	13	100181787	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	661521	100181787	14988091	964	19997										
NALCN	259232	broad.mit.edu	37	chr13	101997647	101997647	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaagccactgtagcccagctCttgcctgctaagtcccagat	8	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr13:101997647C>G	uc001vox.1	-	7	958	c.769G>C	c.(769-771)GAG>CAG	p.E257Q	NALCN_uc001voy.2_Intron|NALCN_uc001voz.2_Missense_Mutation_p.E257Q|NALCN_uc001vpa.2_Missense_Mutation_p.E257Q	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	257	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TAGCCCAGCTCTTGCCTGCTA	0.418													0	0	0	1	0	45	107										G	101997647	C	G	101997647	3	3	65	1	0	0	0	0	1	0	0	0	10148	922	32	1	4599	1	NALCN	13	101997647	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1815860	101997647	13172231	965	19998										
OR11H12	440153	broad.mit.edu	37	chr14	19378098	19378098	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtgctgggtttgtggatttCtgtggttcctgatccccatt	12	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:19378098C>T	uc010tkp.1	+	1	505	c.505C>T	c.(505-507)CTG>TTG	p.L169L		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	169	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGTGGATTTCTGTGGTTCCT	0.483													0	0	0	1	0	11	274										T	19378098	C	T	19378098	2	4	65	1	0	0	0	0	0	0	0	1	10927	912	32	1		1	OR11H12	14	19378098	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		19378098	87971442	966	19999										
OR4K2	390431	broad.mit.edu	37	chr14	20344666	20344666	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttctttcgccaccccaaaGatgattacagattacctaac	5	13	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:20344666G>C	uc001vwh.1	+	1	240	c.240G>C	c.(238-240)AAG>AAC	p.K80N		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCACCCCAAAGATGATTACAG	0.413													0	0	0	1	0	37	417										C	20344666	G	C	20344666	3	2	65	1	0	0	0	0	1	0	0	0	11072	933	33	1	242	1	OR4K2	14	20344666	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	966568	20344666	87004874	967	20000										
OR4K2	390431	broad.mit.edu	37	chr14	20345153	20345153	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccctttctacttgtacagctCatttcattgttgtcttcttg	5	11	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:20345153C>T	uc001vwh.1	+	1	727	c.727C>T	c.(727-729)CAT>TAT	p.H243Y		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGTACAGCTCATTTCATTGT	0.378													0	0	0	1	0	28	214										T	20345153	C	T	20345153	3	4	65	1	0	0	0	0	1	0	0	0	11072	826	29	1	729	1	OR4K2	14	20345153	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	487	20345153	87004387	968	20001										
SUPT16H	11198	broad.mit.edu	37	chr14	21822578	21822578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acactcacgcacctcaccctCaggctccaggaaagaccagc	7	18	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:21822578C>T	uc001wao.2	-	23	3121	c.2782G>A	c.(2782-2784)GAG>AAG	p.E928K	SUPT16H_uc001wan.2_Missense_Mutation_p.E72K	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	928	Glu-rich (acidic).				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		ACCTCACCCTCAGGCTCCAGG	0.478													0	0	0	1	0	8	52										T	21822578	C	T	21822578	3	4	65	1	0	0	0	0	1	0	0	0	15393	835	29	1	377	1	SUPT16H	14	21822578	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1477425	21822578	85526962	969	20002										
CDH24	64403	broad.mit.edu	37	chr14	23524350	23524350	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcgttgatgtcttgcactttGatgatgaactctgatggggg	13	6	2	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:23524350G>A	uc001wil.2	-	3	674	c.414C>T	c.(412-414)ATC>ATT	p.I138I	CDH24_uc010akf.2_Silent_p.I138I|CDH24_uc001win.3_Silent_p.I138I	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	138	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CTTGCACTTTGATGATGAACT	0.587											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	39	136										A	23524350	G	A	23524350	2	1	65	1	0	0	0	0	0	0	0	1	3109	1280	45	1		1	CDH24	14	23524350	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1701772	23524350	83825190	970	20003										
ACIN1	22985	broad.mit.edu	37	chr14	23548985	23548985	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagatgaggaggaccggctaGaggatgaatcagctgactgt	15	6	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:23548985G>C	uc001wit.3	-	6	2061	c.1733C>G	c.(1732-1734)TCT>TGT	p.S578C	ACIN1_uc001wis.3_Missense_Mutation_p.S260C|ACIN1_uc010akg.2_Missense_Mutation_p.S578C|ACIN1_uc010tnj.1_Missense_Mutation_p.S538C	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	578	Ser-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGACCGGCTAGAGGATGAATC	0.498													0	0	0	1	0	26	131										C	23548985	G	C	23548985	3	2	65	1	0	0	0	0	1	0	0	0	142	942	33	1	2495	1	ACIN1	14	23548985	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	24635	23548985	83800555	971	20004										
ACIN1	22985	broad.mit.edu	37	chr14	23549444	23549444	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgtggatgaggtggtggaGaagatgcttcctttgttagt	16	4	0	3	rs151153498		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:23549444G>C	uc001wit.3	-	6	1602	c.1274C>G	c.(1273-1275)TCT>TGT	p.S425C	ACIN1_uc001wis.3_Missense_Mutation_p.S107C|ACIN1_uc010akg.2_Missense_Mutation_p.S425C|ACIN1_uc010tnj.1_Missense_Mutation_p.S385C	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	425	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		AGGTGGTGGAGAAGATGCTTC	0.517													0	0	0	1	0	20	65										C	23549444	G	C	23549444	3	2	65	1	0	0	0	0	1	0	0	0	142	942	33	1	2954	1	ACIN1	14	23549444	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	459	23549444	83800096	972	20005										
MYH6	4624	broad.mit.edu	37	chr14	23863393	23863393	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctttgatgcgcccgaactCttccttcatggtggccatct	8	14	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:23863393C>G	uc001wjv.2	-	21	2636	c.2569G>C	c.(2569-2571)GAG>CAG	p.E857Q		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	857	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CGCCCGAACTCTTCCTTCATG	0.567													0	0	0	1	0	40	125										G	23863393	C	G	23863393	3	3	65	1	0	0	0	0	1	0	0	0	10038	922	32	1	3326	1	MYH6	14	23863393	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	313949	23863393	83486147	973	20006										
MYH6	4624	broad.mit.edu	37	chr14	23865621	23865621	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcccaagcagccctgccttGaagaacacctgcaggcaagg	11	14	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:23865621G>A	uc001wjv.2	-	20	2368	c.2301C>T	c.(2299-2301)TTC>TTT	p.F767F		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	767	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCCCTGCCTTGAAGAACACCT	0.637													0	0	0	1	0	22	50										A	23865621	G	A	23865621	2	1	65	1	0	0	0	0	0	0	0	1	10038	1281	45	1		1	MYH6	14	23865621	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2228	23865621	83483919	974	20007										
MYH7	4625	broad.mit.edu	37	chr14	23899054	23899054	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcatgtttccaaagtgcatGatggcgcctgtcagcttata	9	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:23899054G>A	uc001wjx.2	-	12	1174	c.1068C>T	c.(1066-1068)ATC>ATT	p.I356I		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	356	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAAAGTGCATGATGGCGCCTG	0.562													0	0	0	1	0	34	99										A	23899054	G	A	23899054	2	1	65	1	0	0	0	0	0	0	0	1	10039	1280	45	1		1	MYH7	14	23899054	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	33433	23899054	83450486	975	20008										
DHRS4	10901	broad.mit.edu	37	chr14	24424331	24424331	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcagaatgtggaccaggcGgtggccacgctgcaggggga	18	10	0	1	rs142533242		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:24424331G>A	uc001wla.2	+	2	249	c.216G>A	c.(214-216)GCG>GCA	p.A72A	C14orf167_uc001wkz.2_5'Flank|C14orf167_uc001wky.2_5'Flank|C14orf167_uc001wkx.2_5'Flank|C14orf167_uc010akx.1_5'Flank|DHRS4_uc010aky.2_Silent_p.A72A|DHRS4_uc001wlb.2_Silent_p.A72A|DHRS4_uc010akz.2_Silent_p.A72A|DHRS4_uc001wlc.3_Silent_p.A72A|DHRS4L2_uc001wld.3_Silent_p.A72A|DHRS4L2_uc001wle.3_Silent_p.A72A	NM_021004	NP_066284	Q9BTZ2	DHRS4_HUMAN	peroxisomal short-chain alcohol dehydrogenase	72						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	TGGACCAGGCGGTGGCCACGC	0.692													0	0	0	1	0	36	112										A	24424331	G	A	24424331	2	1	65	1	0	0	0	0	0	0	0	1	4492	1103	39	2		2	DHRS4	14	24424331	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	525277	24424331	82925209	976	20009										
ADCY4	196883	broad.mit.edu	37	chr14	24800506	24800506	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctgcagccgtgccatgatCtctgccttcatctctcgggc	10	16	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:24800506C>G	uc001wov.2	-	5	732	c.726G>C	c.(724-726)GAG>GAC	p.E242D	ADCY4_uc001wow.2_Missense_Mutation_p.E242D|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Missense_Mutation_p.E242D|ADCY4_uc001woy.2_Missense_Mutation_p.E242D	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	242	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GTGCCATGATCTCTGCCTTCA	0.552													0	0	0	1	0	30	92										G	24800506	C	G	24800506	3	3	65	1	0	0	0	0	1	0	0	0	296	912	32	1	2591	1	ADCY4	14	24800506	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	376175	24800506	82549034	977	20010										
ADCY4	196883	broad.mit.edu	37	chr14	24801006	24801006	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggctgacctggtgcttcttCtcggtgtccagccgccggcg	14	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:24801006C>T	uc001wov.2	-	4	663	c.657G>A	c.(655-657)GAG>GAA	p.E219E	ADCY4_uc001wow.2_Silent_p.E219E|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Silent_p.E219E|ADCY4_uc001woy.2_Silent_p.E219E	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	219	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GGTGCTTCTTCTCGGTGTCCA	0.458													0	0	0	1	0	11	27										T	24801006	C	T	24801006	2	4	65	1	0	0	0	0	0	0	0	1	296	912	32	1		1	ADCY4	14	24801006	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	500	24801006	82548534	978	20011										
NYNRIN	57523	broad.mit.edu	37	chr14	24880396	24880396	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccacctggcagctgaagaaGaaccggagggtgagaggtga	16	9	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:24880396G>A	uc001wpf.3	+	5	2847	c.2529G>A	c.(2527-2529)AAG>AAA	p.K843K		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	843					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						AGCTGAAGAAGAACCGGAGGG	0.592											OREG0022626	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	40	144										A	24880396	G	A	24880396	2	1	65	1	0	0	0	0	0	0	0	1	10796	933	33	1		1	NYNRIN	14	24880396	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	79390	24880396	82469144	979	20012										
HECTD1	25831	broad.mit.edu	37	chr14	31572252	31572252	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaacttaatttctccattgGaaaaactttattaaacccat	4	8	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:31572252G>C	uc001wrc.1	-	41	7909	c.7420C>G	c.(7420-7422)CCA>GCA	p.P2474A	HECTD1_uc001wra.1_Missense_Mutation_p.P600A|HECTD1_uc001wrb.1_Missense_Mutation_p.P600A	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2474	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTCTCCATTGGAAAAACTTTA	0.358													0	0	0	1	0	15	47										C	31572252	G	C	31572252	3	2	65	1	0	0	0	0	1	0	0	0	7039	1174	41	1	424	1	HECTD1	14	31572252	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6691856	31572252	75777288	980	20013										
HECTD1	25831	broad.mit.edu	37	chr14	31602831	31602831	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtttaattctcacatgtctcCacccttgtttctcatccttt	3	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:31602831C>A	uc001wrc.1	-	23	4118	c.3629G>T	c.(3628-3630)TGG>TTG	p.W1210L	HECTD1_uc001wrd.1_Missense_Mutation_p.W725L	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1210					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CACATGTCTCCACCCTTGTTT	0.363													1	0	0.00307968	1	0.00310906	8	38										A	31602831	C	A	31602831	3	1	65	1	0	0	0	0	1	0	0	0	7039	595	21	4	4287	4	HECTD1	14	31602831	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	30579	31602831	75746709	981	20014										
HECTD1	25831	broad.mit.edu	37	chr14	31602844	31602844	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgtctccacccttgtttctCatcctttggtggatcaagag	8	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:31602844C>G	uc001wrc.1	-	23	4105	c.3616G>C	c.(3616-3618)GAG>CAG	p.E1206Q	HECTD1_uc001wrd.1_Missense_Mutation_p.E721Q	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1206					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CCTTGTTTCTCATCCTTTGGT	0.363													0	0	0	1	0	7	24										G	31602844	C	G	31602844	3	3	65	1	0	0	0	0	1	0	0	0	7039	835	29	1	4300	1	HECTD1	14	31602844	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	13	31602844	75746696	982	20015										
HEATR5A	25938	broad.mit.edu	37	chr14	31849763	31849763	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcagcagaacacagcaaatCctctgctaatgtcataataa	6	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:31849763C>A	uc001wrf.3	-	5	816	c.739G>T	c.(739-741)GAT>TAT	p.D247Y	HEATR5A_uc010ami.2_Missense_Mutation_p.D145Y|HEATR5A_uc001wrg.1_Missense_Mutation_p.D129Y|HEATR5A_uc010tpk.1_Missense_Mutation_p.D540Y	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	534							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CACAGCAAATCCTCTGCTAAT	0.358													1	0	2.0095e-06	1	2.06813e-06	6	17										A	31849763	C	A	31849763	3	1	65	1	0	0	0	0	1	0	0	0	7031	855	30	3	4626	3	HEATR5A	14	31849763	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	246919	31849763	75499777	983	20016										
MIPOL1	145282	broad.mit.edu	37	chr14	37777576	37777576	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attacaggaattactgaacaGaataaacaatgcagacacag	7	7	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:37777576G>A	uc001wuc.2	+	10	1183	c.680G>A	c.(679-681)AGA>AAA	p.R227K	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Missense_Mutation_p.R196K|MIPOL1_uc001wud.2_Missense_Mutation_p.R227K|MIPOL1_uc010ams.2_Missense_Mutation_p.R227K|MIPOL1_uc001wue.2_Missense_Mutation_p.R196K|MIPOL1_uc010amt.2_Missense_Mutation_p.R46K	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	227										ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		TTACTGAACAGAATAAACAAT	0.308													0	0	0	1	0	20	50										A	37777576	G	A	37777576	3	1	65	1	0	0	0	0	1	0	0	0	9593	942	33	1	706	1	MIPOL1	14	37777576	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5927813	37777576	69571964	984	20017										
SSTR1	6751	broad.mit.edu	37	chr14	38679239	38679239	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacatgctcatgccagagccCgctcaacgctggctggtggg	13	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:38679239C>T	uc001wul.1	+	3	1262	c.645C>T	c.(643-645)CCC>CCT	p.P215P	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	215	Extracellular (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	TGCCAGAGCCCGCTCAACGCT	0.607													0	0	0	1	0	26	81										T	38679239	C	T	38679239	2	4	65	1	0	0	0	0	0	0	0	1	15196	639	23	2		2	SSTR1	14	38679239	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	901663	38679239	68670301	985	20018										
PPIL5	122769	broad.mit.edu	37	chr14	50074583	50074583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcagttttgccagctccagGaacttaagaatttaaaactt	7	8	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:50074583G>A	uc001wwn.2	+	3	1072	c.748G>A	c.(748-750)GAA>AAA	p.E250K	SDCCAG1_uc010anj.1_Intron|PPIL5_uc001wwo.2_Intron|PPIL5_uc010ank.2_Missense_Mutation_p.E191K|PPIL5_uc001wwp.2_RNA	NM_152329	NP_689542	Q96L50	LLR1_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 5	250	LRR 5.										0	all_epithelial(31;0.0021)|Breast(41;0.0124)					CCAGCTCCAGGAACTTAAGAA	0.403													0	0	0	1	0	11	47										A	50074583	G	A	50074583	3	1	65	1	0	0	0	0	1	0	0	0	12330	1175	41	1	758	1	PPIL5	14	50074583	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11395344	50074583	57274957	986	20019										
GCH1	2643	broad.mit.edu	37	chr14	55310749	55310749	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaagctcagctcctaatgaGagtcaggaactcttcccgag	10	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:55310749G>A	uc001xbh.1	-	6	900	c.739C>T	c.(739-741)CTC>TTC	p.L247F	GCH1_uc001xbi.1_Missense_Mutation_p.L247F|GCH1_uc001xbj.1_Intron|GCH1_uc001xbk.1_Intron|GCH1_uc010aol.1_Intron	NM_001024024	NP_001019195	P30793	GCH1_HUMAN	GTP cyclohydrolase 1 isoform 1	247					dopamine biosynthetic process|GTP catabolic process|neuromuscular process controlling posture|nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|protein homooligomerization|response to interferon-gamma|response to lipopolysaccharide|response to pain|response to tumor necrosis factor|tetrahydrobiopterin biosynthetic process|tetrahydrofolate biosynthetic process	cytoplasmic vesicle|cytosol|nuclear membrane|protein complex	GTP binding|GTP cyclohydrolase I activity|protein homodimerization activity|zinc ion binding			skin(1)	1						CTCCTAATGAGAGTCAGGAAC	0.483													0	0	0	1	0	34	87										A	55310749	G	A	55310749	3	1	65	1	0	0	0	0	1	0	0	0	6291	942	33	1	117	1	GCH1	14	55310749	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5236166	55310749	52038791	987	20020										
KIAA0831	22863	broad.mit.edu	37	chr14	55852644	55852644	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctaatatatgggatcgtcGaagatttgccagacgctcat	9	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:55852644G>A	uc001xbx.1	-	5	616	c.580C>T	c.(580-582)CGA>TGA	p.R194*	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Nonsense_Mutation_p.R81*	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	194					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						TGGGATCGTCGAAGATTTGCC	0.408													0	0	0	1	0	8	30										A	55852644	G	A	55852644	4	1	65	1	0	0	0	0	0	1	0	0	8195	1066	37	1	922	1	KIAA0831	14	55852644	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	541895	55852644	51496896	988	20021										
RTN1	6252	broad.mit.edu	37	chr14	60193729	60193729	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggactttggttggaactcGagtcttcttcaggcttccgt	11	10	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:60193729G>A	uc001xen.1	-	3	1882	c.1673C>T	c.(1672-1674)TCG>TTG	p.S558L	RTN1_uc001xem.1_Missense_Mutation_p.S138L	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	558					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GTTGGAACTCGAGTCTTCTTC	0.622													0	0	0	1	0	9	38										A	60193729	G	A	60193729	3	1	65	1	0	0	0	0	1	0	0	0	13725	1059	37	1	750	1	RTN1	14	60193729	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4341085	60193729	47155811	989	20022										
PPM1A	5494	broad.mit.edu	37	chr14	60750112	60750112	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgaaagatctgaagaagatGatcagttcattatccttgca	8	6	3	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:60750112G>A	uc010apn.2	+	3	1093	c.691G>A	c.(691-693)GAT>AAT	p.D231N	PPM1A_uc001xew.3_Missense_Mutation_p.D304N|PPM1A_uc001xex.3_Missense_Mutation_p.D231N|PPM1A_uc001xey.3_Missense_Mutation_p.D231N	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	231					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		TGAAGAAGATGATCAGTTCAT	0.413													0	0	0	1	0	43	96										A	60750112	G	A	60750112	3	1	65	1	0	0	0	0	1	0	0	0	12335	1290	45	1	916	1	PPM1A	14	60750112	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	556383	60750112	46599428	990	20023										
SYT16	83851	broad.mit.edu	37	chr14	62463153	62463153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gttaccacatgtgctttcttCtattgcggaggaagagcatc	10	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:62463153C>G	uc001xfu.1	+	1	613	c.416C>G	c.(415-417)TCT>TGT	p.S139C	SYT16_uc010tsd.1_Missense_Mutation_p.S139C	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	139										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GTGCTTTCTTCTATTGCGGAG	0.478													0	0	0	1	0	39	119										G	62463153	C	G	62463153	3	3	65	1	0	0	0	0	1	0	0	0	15469	913	32	1	418	1	SYT16	14	62463153	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1713041	62463153	44886387	991	20024										
SYNE2	23224	broad.mit.edu	37	chr14	64529564	64529564	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcttggacagtccatgtcctCgttgccactgtcttacagag	9	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:64529564C>T	uc001xgm.2	+	50	10393	c.10163C>T	c.(10162-10164)TCG>TTG	p.S3388L	SYNE2_uc001xgl.2_Missense_Mutation_p.S3388L|SYNE2_uc010apw.1_Missense_Mutation_p.S94L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3388	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCCATGTCCTCGTTGCCACTG	0.398													0	0	0	1	0	13	33										T	64529564	C	T	64529564	3	4	65	1	0	0	0	0	1	0	0	0	15443	893	31	1	10357	1	SYNE2	14	64529564	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2066411	64529564	42819976	992	20025										
SYNE2	23224	broad.mit.edu	37	chr14	64542728	64542728	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attatggaaaaactgcgaatCaagtattccgaaatgtacac	7	7	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:64542728C>G	uc001xgm.2	+	54	11162	c.10932C>G	c.(10930-10932)ATC>ATG	p.I3644M	SYNE2_uc001xgl.2_Missense_Mutation_p.I3644M|SYNE2_uc010apy.2_Missense_Mutation_p.I6M|SYNE2_uc010apw.1_Missense_Mutation_p.I350M|SYNE2_uc010apx.1_Missense_Mutation_p.I36M	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3644	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AACTGCGAATCAAGTATTCCG	0.368													0	0	0	1	0	8	19										G	64542728	C	G	64542728	3	3	65	1	0	0	0	0	1	0	0	0	15443	816	29	1	11142	1	SYNE2	14	64542728	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	13164	64542728	42806812	993	20026										
FNTB	2342	broad.mit.edu	37	chr14	65521359	65521359	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atagcccagcacttcggcagCggagccatgttgcatgatgt	12	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:65521359C>T	uc001xia.2	+	11	1299	c.1134C>T	c.(1132-1134)AGC>AGT	p.S378S	FNTB_uc010tsl.1_Silent_p.S412S|FNTB_uc010tsm.1_Silent_p.S332S|MAX_uc001xic.1_Intron|FNTB_uc001xid.2_Silent_p.S134S|FNTB_uc010tso.1_Silent_p.S293S	NM_002028	NP_002019	P49356	FNTB_HUMAN	farnesyltransferase, CAAX box, beta	378					protein farnesylation	microtubule associated complex	protein binding|protein farnesyltransferase activity			ovary(1)	1				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		ACTTCGGCAGCGGAGCCATGT	0.612													0	0	0	1	0	8	28										T	65521359	C	T	65521359	2	4	65	1	0	0	0	0	0	0	0	1	5978	767	27	2		2	FNTB	14	65521359	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	978631	65521359	41828181	994	20027										
RDH12	145226	broad.mit.edu	37	chr14	68196080	68196080	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgagggcctggagcccctGagtggcaagtacttcaggtg	16	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:68196080G>C	uc001xjz.3	+	8	1155	c.831G>C	c.(829-831)CTG>CTC	p.L277L		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	277					photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	TGGAGCCCCTGAGTGGCAAGT	0.637													0	0	0	1	0	25	81										C	68196080	G	C	68196080	2	2	65	1	0	0	0	0	0	0	0	1	13191	1277	45	1		1	RDH12	14	68196080	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2674721	68196080	39153460	995	20028										
ZFYVE26	23503	broad.mit.edu	37	chr14	68217796	68217796	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcatcattgtgtattgcctgGatcaggccctccagctcctg	9	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:68217796G>C	uc001xka.2	-	41	7528	c.7389C>G	c.(7387-7389)ATC>ATG	p.I2463M	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkb.2_Missense_Mutation_p.I309M	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2463					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GTATTGCCTGGATCAGGCCCT	0.552													0	0	0	1	0	24	60										C	68217796	G	C	68217796	3	2	65	1	0	0	0	0	1	0	0	0	17665	1164	41	1	238	1	ZFYVE26	14	68217796	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	21716	68217796	39131744	996	20029										
C14orf181	400223	broad.mit.edu	37	chr14	69262700	69262700	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggtgcaggaaggccgaggcGaggcgtgcgtggccgtcccc	19	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:69262700G>A	uc001xkj.1	-	1	491	c.312C>T	c.(310-312)CTC>CTT	p.L104L	ZFP36L1_uc001xkh.1_5'Flank|ZFP36L1_uc001xki.1_5'Flank	NM_207442	NP_997325			hypothetical protein LOC400223												0				all cancers(60;0.002)|BRCA - Breast invasive adenocarcinoma(234;0.00204)|OV - Ovarian serous cystadenocarcinoma(108;0.0399)		AGGCCGAGGCGAGGCGTGCGT	0.761													0	0	0	1	0	4	24										A	69262700	G	A	69262700	2	1	65	1	0	0	0	0	0	0	0	1	1764	1045	37	1		1	C14orf181	14	69262700	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1044904	69262700	38086840	997	20030										
ADAM20	8748	broad.mit.edu	37	chr14	70989717	70989717	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccccagcaagtggtgtcattGaggtgaaactgctgcactgt	12	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:70989717G>A	uc001xme.2	-	2	2153	c.1908C>T	c.(1906-1908)CTC>CTT	p.L636L		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	586	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TGGTGTCATTGAGGTGAAACT	0.448													0	0	0	1	0	35	87										A	70989717	G	A	70989717	2	1	65	1	0	0	0	0	0	0	0	1	242	1277	45	1		1	ADAM20	14	70989717	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1727017	70989717	36359823	998	20031										
HEATR4	399671	broad.mit.edu	37	chr14	73987670	73987670	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgggagaggctcgtcttttCatggatatcctcagtgctct	11	10	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:73987670C>T	uc010tub.1	-	4	1277	c.955G>A	c.(955-957)GAA>AAA	p.E319K	HEATR4_uc010tua.1_Missense_Mutation_p.E272K	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		CTCGTCTTTTCATGGATATCC	0.517													0	0	0	1	0	26	76										T	73987670	C	T	73987670	3	4	65	1	0	0	0	0	1	0	0	0	7030	835	29	1	2185	1	HEATR4	14	73987670	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2997953	73987670	33361870	999	20032										
C14orf43	91748	broad.mit.edu	37	chr14	74203808	74203808	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggacccttcccgtcctcatCaagacctccagcctgggctg	9	17	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:74203808C>G	uc001xot.2	-	3	2425	c.1642G>C	c.(1642-1644)GAT>CAT	p.D548H	C14orf43_uc001xou.2_Missense_Mutation_p.D548H|C14orf43_uc010tud.1_Missense_Mutation_p.D548H|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		CCGTCCTCATCAAGACCTCCA	0.607													0	0	0	1	0	33	72										G	74203808	C	G	74203808	3	3	65	1	0	0	0	0	1	0	0	0	1774	826	29	1	1535	1	C14orf43	14	74203808	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	216138	74203808	33145732	1000	20033										
C14orf43	91748	broad.mit.edu	37	chr14	74203900	74203900	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtaccatcccactgtcttctCgtgctcgcttggtggctaag	10	13	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:74203900C>T	uc001xot.2	-	3	2333	c.1550G>A	c.(1549-1551)CGA>CAA	p.R517Q	C14orf43_uc001xou.2_Missense_Mutation_p.R517Q|C14orf43_uc010tud.1_Missense_Mutation_p.R517Q|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		ACTGTCTTCTCGTGCTCGCTT	0.552													0	0	0	1	0	15	52										T	74203900	C	T	74203900	3	4	65	1	0	0	0	0	1	0	0	0	1774	884	31	1	1627	1	C14orf43	14	74203900	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	92	74203900	33145640	1001	20034										
COQ6	51004	broad.mit.edu	37	chr14	74428472	74428472	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acctcacaggttatgaaacaGaaagacagcgtcacaacact	7	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:74428472G>C	uc001xph.2	+	11	1323	c.1243G>C	c.(1243-1245)GAA>CAA	p.E415Q	ENTPD5_uc001xpi.2_Intron|COQ6_uc001xpe.2_Missense_Mutation_p.E340Q|COQ6_uc001xpf.2_Missense_Mutation_p.E340Q|COQ6_uc010tuk.1_Missense_Mutation_p.E390Q|COQ6_uc001xpg.2_Intron	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	415					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TTATGAAACAGAAAGACAGCG	0.483													0	0	0	1	0	56	160										C	74428472	G	C	74428472	3	2	65	1	0	0	0	0	1	0	0	0	3749	943	33	1	1285	1	COQ6	14	74428472	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	224572	74428472	32921068	1002	20035										
C14orf115	55237	broad.mit.edu	37	chr14	74824374	74824374	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcgtcaccaaaagcaccttCtaccgctggcggcggcagtc	11	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:74824374C>G	uc001xpw.3	+	2	1079	c.888C>G	c.(886-888)TTC>TTG	p.F296L		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	296					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		AAAGCACCTTCTACCGCTGGC	0.647													0	0	0	1	0	33	89										G	74824374	C	G	74824374	3	3	65	1	0	0	0	0	1	0	0	0	1740	912	32	1	890	1	C14orf115	14	74824374	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	395902	74824374	32525166	1003	20036										
MLH3	27030	broad.mit.edu	37	chr14	75513113	75513113	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acatccacagccacagttgtCaggtctttagtacaagcagc	8	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:75513113C>T	uc001xrd.1	-	2	3462	c.3246G>A	c.(3244-3246)CTG>CTA	p.L1082L	MLH3_uc001xre.1_Silent_p.L1082L|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	1082					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		CCACAGTTGTCAGGTCTTTAG	0.438								MMR					0	0	0	1	0	25	75										T	75513113	C	T	75513113	2	4	65	1	0	0	0	0	0	0	0	1	9618	813	29	1		1	MLH3	14	75513113	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	688739	75513113	31836427	1004	20037										
MLH3	27030	broad.mit.edu	37	chr14	75514904	75514904	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaaagattttttatgtttCtcattttctccagcttctga	6	7	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:75514904C>T	uc001xrd.1	-	2	1671	c.1455G>A	c.(1453-1455)GAG>GAA	p.E485E	MLH3_uc001xre.1_Silent_p.E485E|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	485					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)		TTTTATGTTTCTCATTTTCTC	0.363								MMR					0	0	0	1	0	28	78										T	75514904	C	T	75514904	2	4	65	1	0	0	0	0	0	0	0	1	9618	912	32	1		1	MLH3	14	75514904	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1791	75514904	31834636	1005	20038										
NEK9	91754	broad.mit.edu	37	chr14	75563842	75563842	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccatccacggcaagacaggtCcgggacatgatgcagagatc	12	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:75563842C>T	uc001xrl.2	-	17	2288	c.2134G>A	c.(2134-2136)GAC>AAC	p.D712N	NEK9_uc001xrk.2_Missense_Mutation_p.D212N	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	712	RCC1 6.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		CAAGACAGGTCCGGGACATGA	0.522													0	0	0	1	0	12	45										T	75563842	C	T	75563842	3	4	65	1	0	0	0	0	1	0	0	0	10331	855	30	1	829	1	NEK9	14	75563842	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	48938	75563842	31785698	1006	20039										
FLVCR2	55640	broad.mit.edu	37	chr14	76045555	76045555	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacctcagcgtgatcaaggtGagcaggcgccgttgggccgt	16	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:76045555G>A	uc001xrs.2	+	1	616	c.240G>A	c.(238-240)GTG>GTA	p.V80V		NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	80					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGATCAAGGTGAGCAGGCGCC	0.597													0	0	0	1	0	43	141										A	76045555	G	A	76045555	2	1	65	1	0	0	0	0	0	0	0	1	5946	1277	45	1		1	FLVCR2	14	76045555	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	481713	76045555	31303985	1007	20040										
C14orf118	55668	broad.mit.edu	37	chr14	76638345	76638345	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttccacattccttttaccttCtcggccagctcaaagaggtg	7	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:76638345C>G	uc001xsh.2	+	4	973	c.887C>G	c.(886-888)TCT>TGT	p.S296C	C14orf118_uc001xsi.2_Missense_Mutation_p.S296C|C14orf118_uc001xsj.1_Missense_Mutation_p.S296C|C14orf118_uc001xsk.1_Missense_Mutation_p.S296C|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	296										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		CTTTTACCTTCTCGGCCAGCT	0.443													0	0	0	1	0	22	57										G	76638345	C	G	76638345	3	3	65	1	0	0	0	0	1	0	0	0	1741	913	32	1	897	1	C14orf118	14	76638345	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	592790	76638345	30711195	1008	20041										
C14orf4	64207	broad.mit.edu	37	chr14	77493965	77493965	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagcagccgtgcgcccgcttCagctggcgcgctgtctcgat	13	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:77493965C>T	uc001xsy.2	-	1	1070	c.171G>A	c.(169-171)CTG>CTA	p.L57L		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	57						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		GCGCCCGCTTCAGCTGGCGCG	0.502													0	0	0	1	0	9	18										T	77493965	C	T	77493965	2	4	65	1	0	0	0	0	0	0	0	1	1773	813	29	1		1	C14orf4	14	77493965	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	855620	77493965	29855575	1009	20042										
TMEM63C	57156	broad.mit.edu	37	chr14	77706018	77706018	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggaaggtgatgatcaggatCcacccctgtgcccgcctgtg	14	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:77706018C>T	uc001xtf.2	+	12	1091	c.879C>T	c.(877-879)ATC>ATT	p.I293I	TMEM63C_uc010asq.1_Silent_p.I293I	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	293						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		TGATCAGGATCCACCCCTGTG	0.612													0	0	0	1	0	13	33										T	77706018	C	T	77706018	2	4	65	1	0	0	0	0	0	0	0	1	16189	845	30	1		1	TMEM63C	14	77706018	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	212053	77706018	29643522	1010	20043										
POMT2	29954	broad.mit.edu	37	chr14	77746776	77746776	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagggtttggacgtgaactCattgtccttgggtttgaggc	14	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:77746776C>T	uc001xti.2	-	16	1885	c.1684G>A	c.(1684-1686)GAG>AAG	p.E562K	POMT2_uc001xth.1_Missense_Mutation_p.E260K	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	562					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		GACGTGAACTCATTGTCCTTG	0.532													0	0	0	1	0	30	64										T	77746776	C	T	77746776	3	4	65	1	0	0	0	0	1	0	0	0	12246	835	29	1	592	1	POMT2	14	77746776	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	40758	77746776	29602764	1011	20044										
SPTLC2	9517	broad.mit.edu	37	chr14	78063675	78063675	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtgtttcttcaaaagcttCattaaacggtcttttatata	6	6	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:78063675C>T	uc001xub.2	-	2	369	c.181G>A	c.(181-183)GAA>AAA	p.E61K		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	61				EAFE -> TLAR (in Ref. 5; AAC50871).		integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TCAAAAGCTTCATTAAACGGT	0.383													0	0	0	1	0	8	46										T	78063675	C	T	78063675	3	4	65	1	0	0	0	0	1	0	0	0	15123	835	29	1	1551	1	SPTLC2	14	78063675	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	316899	78063675	29285865	1012	20045										
PTPN21	11099	broad.mit.edu	37	chr14	88945337	88945337	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaccggccttttcttcagaGagtccctccgggctcggtag	11	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:88945337G>C	uc001xwv.3	-	13	2769	c.2438C>G	c.(2437-2439)TCT>TGT	p.S813C	PTPN21_uc010twc.1_Missense_Mutation_p.S609C	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	813						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TTTCTTCAGAGAGTCCCTCCG	0.662													0	0	0	1	0	42	110										C	88945337	G	C	88945337	3	2	65	1	0	0	0	0	1	0	0	0	12786	942	33	1	1114	1	PTPN21	14	88945337	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	10881662	88945337	18404203	1013	20046										
EML5	161436	broad.mit.edu	37	chr14	89131686	89131686	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcaatggatcttaccaggtGaaaatcgaatatctgaaatc	7	7	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:89131686G>A	uc001xxg.2	-	23	3458	c.3272C>T	c.(3271-3273)TCA>TTA	p.S1091L	EML5_uc001xxf.2_5'UTR|EML5_uc001xxh.1_Missense_Mutation_p.S230L	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1091	WD 18.					cytoplasm|microtubule				ovary(3)	3						CTTACCAGGTGAAAATCGAAT	0.333													0	0	0	1	0	6	18										A	89131686	G	A	89131686	3	1	65	1	0	0	0	0	1	0	0	0	5100	1294	45	1	2749	1	EML5	14	89131686	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	186349	89131686	18217854	1014	20047										
TTC7B	145567	broad.mit.edu	37	chr14	91282539	91282539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgttggcgatgagcttggccGacagctgcttgacgagctca	14	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:91282539G>A	uc001xyp.2	-	1	223	c.101C>T	c.(100-102)TCG>TTG	p.S34L		NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	34							binding			ovary(2)	2		Melanoma(154;0.222)				GAGCTTGGCCGACAGCTGCTT	0.418													0	0	0	1	0	10	39										A	91282539	G	A	91282539	3	1	65	1	0	0	0	0	1	0	0	0	16710	1059	37	1	2510	1	TTC7B	14	91282539	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2150853	91282539	16067001	1015	20048										
RPS6KA5	9252	broad.mit.edu	37	chr14	91372534	91372534	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatttcatctgcatcacgtgGaccacatcccaatctcttct	5	14	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:91372534G>A	uc001xys.2	-	8	1131	c.916C>T	c.(916-918)CCA>TCA	p.P306S	RPS6KA5_uc010twi.1_Missense_Mutation_p.P227S|RPS6KA5_uc001xyt.2_Missense_Mutation_p.P306S|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	306	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		GCATCACGTGGACCACATCCC	0.408													0	0	0	1	0	12	69										A	91372534	G	A	91372534	3	1	65	1	0	0	0	0	1	0	0	0	13654	1174	41	1	1538	1	RPS6KA5	14	91372534	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	89995	91372534	15977006	1016	20049										
ATXN3	4287	broad.mit.edu	37	chr14	92560118	92560118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatcctgagcctctgatactCtggactgttgaacaggatta	10	9	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:92560118C>G	uc001yac.3	-	4	361	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	ATXN3_uc010aug.2_Missense_Mutation_p.E83Q|ATXN3_uc001yad.3_Missense_Mutation_p.E43Q|ATXN3_uc010auh.2_Intron|ATXN3_uc001yae.3_Intron|ATXN3_uc010twl.1_Intron	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	98	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		CTCTGATACTCTGGACTGTTG	0.333													0	0	0	1	0	15	62										G	92560118	C	G	92560118	3	3	65	1	0	0	0	0	1	0	0	0	1213	922	32	1	825	1	ATXN3	14	92560118	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1187584	92560118	14789422	1017	20050										
KIAA1409	57578	broad.mit.edu	37	chr14	94044269	94044269	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcctttccagagtccgtttCggagtcctttgcgtagtccg	11	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:94044269C>T	uc001ybv.1	+	15	1845	c.1762C>T	c.(1762-1764)CGG>TGG	p.R588W	KIAA1409_uc001ybs.1_Missense_Mutation_p.R588W	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	765						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GAGTCCGTTTCGGAGTCCTTT	0.448													0	0	0	1	0	37	168										T	94044269	C	T	94044269	3	4	65	1	0	0	0	0	1	0	0	0	8230	875	31	1	1820	1	KIAA1409	14	94044269	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1484151	94044269	13305271	1018	20051										
EML1	2009	broad.mit.edu	37	chr14	100405533	100405533	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtttgtggtctttgttttaGgagtgtggccagaaggctcg	15	5	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:100405533G>T	uc001ygs.2	+	21	2261	c.2192_splice	c.e21-1	p.G731_splice	EML1_uc010tww.1_Splice_Site_p.G719_splice|EML1_uc001ygr.2_Splice_Site_p.G750_splice	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1							cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				CTTTGTTTTAGGAGTGTGGCC	0.572													1	0	1.02788e-11	1	1.07753e-11	16	77										T	100405533	G	T	100405533	5	4	65	1	0	0	0	0	0	0	1	0	5096	1014	35	4	2334	4	EML1	14	100405533	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6361264	100405533	6944007	1019	20052										
EML1	2009	broad.mit.edu	37	chr14	100405640	100405640	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttggcaaagtgcacctcttCtcatacccctgctcgcagtt	7	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:100405640C>G	uc001ygs.2	+	21	2367	c.2298C>G	c.(2296-2298)TTC>TTG	p.F766L	EML1_uc010tww.1_Missense_Mutation_p.F754L|EML1_uc001ygr.2_Missense_Mutation_p.F785L	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	766	WD 10.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TGCACCTCTTCTCATACCCCT	0.537													0	0	0	1	0	20	67										G	100405640	C	G	100405640	3	3	65	1	0	0	0	0	1	0	0	0	5096	912	32	1	2441	1	EML1	14	100405640	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	107	100405640	6943900	1020	20053										
BEGAIN	57596	broad.mit.edu	37	chr14	101005143	101005143	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcgacgcggtcagcgtgctGgcctgcgcgtgctccttctc	14	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:101005143G>A	uc010txa.1	-	6	1091	c.945C>T	c.(943-945)GCC>GCT	p.A315A	BEGAIN_uc001yhp.2_Silent_p.A251A|BEGAIN_uc001yhq.2_Silent_p.A315A	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	315						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				TCAGCGTGCTGGCCTGCGCGT	0.672													0	0	0	1	0	9	17										A	101005143	G	A	101005143	2	1	65	1	0	0	0	0	0	0	0	1	1397	1335	47	2		2	BEGAIN	14	101005143	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	599503	101005143	6344397	1021	20054										
BEGAIN	57596	broad.mit.edu	37	chr14	101005461	101005461	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtttctccaccccgtcgcaGaaggccaggtcgcgggcgga	15	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:101005461G>A	uc010txa.1	-	6	773	c.627C>T	c.(625-627)TTC>TTT	p.F209F	BEGAIN_uc001yhp.2_Silent_p.F145F|BEGAIN_uc001yhq.2_Silent_p.F209F	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	209						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				CCCCGTCGCAGAAGGCCAGGT	0.692													0	0	0	1	0	10	29										A	101005461	G	A	101005461	2	1	65	1	0	0	0	0	0	0	0	1	1397	933	33	1		1	BEGAIN	14	101005461	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	318	101005461	6344079	1022	20055										
PLD4	122618	broad.mit.edu	37	chr14	105397102	105397102	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaggagcttggcgctgtcatCtataactgcagccacctggc	11	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:105397102C>T	uc001ypu.1	+	7	882	c.741C>T	c.(739-741)ATC>ATT	p.I247I	PLD4_uc010tyl.1_Silent_p.I254I	NM_138790	NP_620145	Q96BZ4	PLD4_HUMAN	phospholipase D4	247					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|skin(1)	2		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	GCGCTGTCATCTATAACTGCA	0.617													0	0	0	1	0	39	119										T	105397102	C	T	105397102	2	4	65	1	0	0	0	0	0	0	0	1	12048	903	32	1		1	PLD4	14	105397102	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4391641	105397102	1952438	1023	20056										
AHNAK2	113146	broad.mit.edu	37	chr14	105410848	105410848	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggggccgataccctgaatGacggcatcttgaatttgggc	13	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:105410848G>T	uc010axc.1	-	7	11060	c.10940C>A	c.(10939-10941)TCA>TAA	p.S3647*	AHNAK2_uc001ypx.2_Nonsense_Mutation_p.S3547*	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3647						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TACCCTGAATGACGGCATCTT	0.587													1	0	1.07134e-49	1	1.14723e-49	85	307										T	105410848	G	T	105410848	4	4	65	1	0	0	0	0	0	1	0	0	415	1294	45	3	6451	3	AHNAK2	14	105410848	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13746	105410848	1938692	1024	20057										
AHNAK2	113146	broad.mit.edu	37	chr14	105415185	105415185	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcggaaaggggctgaatgctGaggtcagtggtcttgaggtc	18	6	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr14:105415185G>A	uc010axc.1	-	7	6723	c.6603C>T	c.(6601-6603)CTC>CTT	p.L2201L	AHNAK2_uc001ypx.2_Silent_p.L2101L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2201						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTGAATGCTGAGGTCAGTGG	0.637													0	0	0	1	0	78	135										A	105415185	G	A	105415185	2	1	65	1	0	0	0	0	0	0	0	1	415	1277	45	1		1	AHNAK2	14	105415185	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4337	105415185	1934355	1025	20058										
MAGEL2	54551	broad.mit.edu	37	chr15	23889330	23889330	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctggtttccaggaatgctCgagggccccagaggaactca	13	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:23889330C>T	uc001ywj.3	-	1	1846	c.1751G>A	c.(1750-1752)CGA>CAA	p.R584Q		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CAGGAATGCTCGAGGGCCCCA	0.512													0	0	0	1	0	23	51										T	23889330	C	T	23889330	3	4	65	1	0	0	0	0	1	0	0	0	9189	884	31	1	193	1	MAGEL2	15	23889330	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		23889330	78642062	1026	20059										
APBA2	321	broad.mit.edu	37	chr15	29367150	29367150	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatggtctggagcagccaagGaagcagcagcgctctgatct	13	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:29367150G>A	uc001zck.2	+	4	1185	c.978G>A	c.(976-978)AGG>AGA	p.R326R	APBA2_uc010azj.2_Silent_p.R326R|APBA2_uc010uat.1_Silent_p.R326R|APBA2_uc001zcl.2_Silent_p.R326R|APBA2_uc001zcm.1_Silent_p.R30R	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	326					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		AGCAGCCAAGGAAGCAGCAGC	0.418													0	0	0	1	0	13	28										A	29367150	G	A	29367150	2	1	65	1	0	0	0	0	0	0	0	1	757	1165	41	1		1	APBA2	15	29367150	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5477820	29367150	73164242	1027	20060										
CHRFAM7A	89832	broad.mit.edu	37	chr15	30659650	30659650	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catcttgcccccgtcggggtCgtggtggtggtactgcagca	15	12	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:30659650C>T	uc001zdt.1	-	9	1257	c.691G>A	c.(691-693)GAC>AAC	p.D231N	DKFZP434L187_uc001zds.2_Intron|CHRFAM7A_uc001zdu.1_Missense_Mutation_p.D140N|CHRFAM7A_uc010azn.2_Missense_Mutation_p.D140N	NM_139320	NP_647536	Q494W8	CRFM7_HUMAN	CHRNA7-FAM7A fusion isoform 1	231						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			skin(1)	1		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CCGTCGGGGTCGTGGTGGTGG	0.597													0	0	0	1	0	12	68										T	30659650	C	T	30659650	3	4	65	1	0	0	0	0	1	0	0	0	3375	884	31	1	555	1	CHRFAM7A	15	30659650	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1292500	30659650	71871742	1028	20061										
MTMR10	54893	broad.mit.edu	37	chr15	31239356	31239356	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctttgcttcactcgctggtGaggggagttgaacaggaagg	16	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:31239356G>A	uc001zfh.1	-	14	1623	c.1525C>T	c.(1525-1527)CAC>TAC	p.H509Y	MTMR10_uc010ubk.1_5'UTR|MTMR10_uc001zfg.1_Missense_Mutation_p.H90Y|MTMR10_uc010azx.1_Missense_Mutation_p.H261Y|MTMR10_uc001zfi.1_Missense_Mutation_p.H261Y|MTMR10_uc001zfj.2_Missense_Mutation_p.H427Y|MTMR10_uc001zfk.2_Missense_Mutation_p.H261Y	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	509	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		ACTCGCTGGTGAGGGGAGTTG	0.473													0	0	0	1	0	31	109										A	31239356	G	A	31239356	3	1	65	1	0	0	0	0	1	0	0	0	9939	1290	45	1	820	1	MTMR10	15	31239356	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	579706	31239356	71292036	1029	20062										
TRPM1	4308	broad.mit.edu	37	chr15	31360134	31360134	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccggtggtcatagcagccttGatcaggcctttcccaaagac	10	13	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:31360134G>A	uc001zfm.2	-	4	503	c.375C>T	c.(373-375)ATC>ATT	p.I125I	TRPM1_uc010azy.2_Silent_p.I38I|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	125	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TAGCAGCCTTGATCAGGCCTT	0.547													0	0	0	1	0	38	131										A	31360134	G	A	31360134	2	1	65	1	0	0	0	0	0	0	0	1	16582	1280	45	1		1	TRPM1	15	31360134	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	120778	31360134	71171258	1030	20063										
RYR3	6263	broad.mit.edu	37	chr15	34061318	34061318	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttttttattccaggtagtGattctactacaatggtgagc	8	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:34061318G>A	uc001zhi.2	+	62	8831	c.8761G>A	c.(8761-8763)GAT>AAT	p.D2921N	RYR3_uc010bar.2_Missense_Mutation_p.D2921N	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2921	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCAGGTAGTGATTCTACTAC	0.438													0	0	0	1	0	24	67										A	34061318	G	A	34061318	3	1	65	1	0	0	0	0	1	0	0	0	13770	1290	45	1	9007	1	RYR3	15	34061318	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2701184	34061318	68470074	1031	20064										
C15orf54	400360	broad.mit.edu	37	chr15	39544555	39544555	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacatcgccctgtcagaaatGactttcagggaacagacatc	8	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:39544555G>C	uc001zkg.2	+	2	587	c.219G>C	c.(217-219)ATG>ATC	p.M73I		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	73											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		TGTCAGAAATGACTTTCAGGG	0.423													0	0	0	1	0	66	144										C	39544555	G	C	39544555	3	2	65	1	0	0	0	0	1	0	0	0	1802	1290	45	1	221	1	C15orf54	15	39544555	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5483237	39544555	62986837	1032	20065										
DISP2	85455	broad.mit.edu	37	chr15	40655912	40655912	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctggaggacccttccagctCttcaggacccccaccaacaa	7	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:40655912C>T	uc001zlk.1	+	2	295	c.206C>T	c.(205-207)TCT>TTT	p.S69F		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	69					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCTTCCAGCTCTTCAGGACCC	0.637													0	0	0	1	0	48	149										T	40655912	C	T	40655912	3	4	65	1	0	0	0	0	1	0	0	0	4540	913	32	1	212	1	DISP2	15	40655912	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1111357	40655912	61875480	1033	20066										
UBR1	197131	broad.mit.edu	37	chr15	43294805	43294805	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggggatcacagtattgcacaGagatttgcaaagagggcaaa	13	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:43294805G>A	uc001zqq.2	-	32	3673	c.3607C>T	c.(3607-3609)CTG>TTG	p.L1203L		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1203					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GTATTGCACAGAGATTTGCAA	0.343													0	0	0	1	0	14	72										A	43294805	G	A	43294805	2	1	65	1	0	0	0	0	0	0	0	1	16898	933	33	1		1	UBR1	15	43294805	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2638893	43294805	59236587	1034	20067										
DUT	1854	broad.mit.edu	37	chr15	48623792	48623792	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcagcgatgcaaaacgcgcGaggcgcacggcagagggccg	16	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:48623792G>C	uc001zws.2	+	1	172	c.80G>C	c.(79-81)CGA>CCA	p.R27P	DUT_uc001zwt.2_Intron|DUT_uc001zwu.2_RNA|DUT_uc001zwv.2_5'Flank|DUT_uc001zww.2_5'Flank|uc010ben.1_RNA	NM_001025248	NP_001020419	P33316	DUT_HUMAN	deoxyuridine triphosphatase isoform 1 precursor	27					DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding				0		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)		CAAAACGCGCGAGGCGCACGG	0.701								Modulation_of_nucleotide_pools					0	0	0	1	0	3	12										C	48623792	G	C	48623792	3	2	65	1	0	0	0	0	1	0	0	0	4833	1058	37	1	82	1	DUT	15	48623792	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5328987	48623792	53907600	1035	20068										
USP8	9101	broad.mit.edu	37	chr15	50769684	50769684	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagccagtgcctagtataaaGaatgttccacaggtatgttc	9	9	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:50769684G>A	uc001zym.3	+	11	1706	c.1206G>A	c.(1204-1206)AAG>AAA	p.K402K	USP8_uc001zyk.1_Silent_p.K103K|USP8_uc001zyl.3_Silent_p.K402K|USP8_uc001zyn.3_Silent_p.K402K|USP8_uc010ufh.1_Silent_p.K325K|USP8_uc010bev.1_Silent_p.K31K	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	402					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CTAGTATAAAGAATGTTCCAC	0.284													0	0	0	1	0	20	81										A	50769684	G	A	50769684	2	1	65	1	0	0	0	0	0	0	0	1	17086	933	33	1		1	USP8	15	50769684	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2145892	50769684	51761708	1036	20069										
DMXL2	23312	broad.mit.edu	37	chr15	51783938	51783938	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccaggcaaaatggcatgtaGagacacctaaattggaaata	9	8	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:51783938G>C	uc002abf.2	-	20	5015	c.4790C>G	c.(4789-4791)TCT>TGT	p.S1597C	DMXL2_uc010ufy.1_Missense_Mutation_p.S1597C|DMXL2_uc010bfa.2_Missense_Mutation_p.S961C	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1597						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		ATGGCATGTAGAGACACCTAA	0.363													0	0	0	1	0	30	77										C	51783938	G	C	51783938	3	2	65	1	0	0	0	0	1	0	0	0	4595	942	33	1	4419	1	DMXL2	15	51783938	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1014254	51783938	50747454	1037	20070										
GNB5	10681	broad.mit.edu	37	chr15	52416714	52416714	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agagcagaaagcagtcccatCgggggaaactcgtagagtgc	14	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:52416714C>T	uc002abt.1	-	12	1197	c.1132G>A	c.(1132-1134)GAT>AAT	p.D378N	GNB5_uc002abr.1_Missense_Mutation_p.D336N|GNB5_uc002abs.1_Missense_Mutation_p.D266N	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	378	WD 7.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		GCAGTCCCATCGGGGGAAACT	0.498													0	0	0	1	0	18	65										T	52416714	C	T	52416714	3	4	65	1	0	0	0	0	1	0	0	0	6521	884	31	1	63	1	GNB5	15	52416714	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	632776	52416714	50114678	1038	20071										
MYO1E	4643	broad.mit.edu	37	chr15	59466040	59466040	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctgggtgctcttccatccCaatataatcccctataaagt	5	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:59466040C>G	uc002aga.2	-	21	2611	c.2239G>C	c.(2239-2241)GGG>CGG	p.G747R	MIR2116_hsa-mir-2116|MI0010635_5'Flank	NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	747					actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		TCTTCCATCCCAATATAATCC	0.458													0	0	0	1	0	55	182										G	59466040	C	G	59466040	3	3	65	1	0	0	0	0	1	0	0	0	10072	594	21	4	1119	4	MYO1E	15	59466040	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7049326	59466040	43065352	1039	20072										
GCNT3	9245	broad.mit.edu	37	chr15	59910809	59910809	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagttcatacagttcccactGagcaaagaagaggtggagtt	11	7	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:59910809G>A	uc002age.2	+	3	821	c.372G>A	c.(370-372)CTG>CTA	p.L124L	GCNT3_uc002agd.2_Silent_p.L124L	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	124	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						AGTTCCCACTGAGCAAAGAAG	0.473													0	0	0	1	0	20	58										A	59910809	G	A	59910809	2	1	65	1	0	0	0	0	0	0	0	1	6302	1277	45	1		1	GCNT3	15	59910809	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	444769	59910809	42620583	1040	20073										
GCNT3	9245	broad.mit.edu	37	chr15	59911184	59911184	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcaagatgttgaatgggagGaatagcatggagtcagaggt	15	4	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:59911184G>A	uc002age.2	+	3	1196	c.747G>A	c.(745-747)AGG>AGA	p.R249R	GCNT3_uc002agd.2_Silent_p.R249R	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	249	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						TGAATGGGAGGAATAGCATGG	0.458													0	0	0	1	0	58	139										A	59911184	G	A	59911184	2	1	65	1	0	0	0	0	0	0	0	1	6302	1165	41	1		1	GCNT3	15	59911184	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	375	59911184	42620208	1041	20074										
RORA	6095	broad.mit.edu	37	chr15	60789729	60789729	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatggaggaaaatgaagtcgCacaatgtctgggtatattgc	12	5	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:60789729C>T	uc002agv.2	-	12	1752	c.1596G>A	c.(1594-1596)GTG>GTA	p.V532V	uc002ags.1_Intron|RORA_uc002agt.3_Silent_p.V444V|RORA_uc002agw.2_Silent_p.V524V|RORA_uc002agx.2_Silent_p.V499V	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	532	Ligand-binding.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AATGAAGTCGCACAATGTCTG	0.378													0	0	0	1	0	10	44										T	60789729	C	T	60789729	2	4	65	1	0	0	0	0	0	0	0	1	13528	697	25	2		2	RORA	15	60789729	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	878545	60789729	41741663	1042	20075										
HERC1	8925	broad.mit.edu	37	chr15	63916468	63916468	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agactcttggggctaacaaaGgccgaagttgtccctgtaca	11	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:63916468G>T	uc002amp.2	-	72	13482	c.13334C>A	c.(13333-13335)CCT>CAT	p.P4445H		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4445					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GGCTAACAAAGGCCGAAGTTG	0.453													1	0	5.60225e-13	1	5.88375e-13	31	75										T	63916468	G	T	63916468	3	4	65	1	0	0	0	0	1	0	0	0	7057	1000	35	4	1279	4	HERC1	15	63916468	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3126739	63916468	38614924	1043	20076										
CILP	8483	broad.mit.edu	37	chr15	65497670	65497670	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgaccctcttcgctggcctCactgcacagcgacaccatct	7	18	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:65497670C>T	uc002aon.2	-	5	740	c.559G>A	c.(559-561)GAG>AAG	p.E187K		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	187	TSP type-1.				negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TCGCTGGCCTCACTGCACAGC	0.617													0	0	0	1	0	33	97										T	65497670	C	T	65497670	3	4	65	1	0	0	0	0	1	0	0	0	3429	835	29	1	3015	1	CILP	15	65497670	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1581202	65497670	37033722	1044	20077										
PTPLAD1	51495	broad.mit.edu	37	chr15	65847289	65847289	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggagttcttagaccttgtGaaaccagaggtatgttcttt	10	7	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:65847289G>A	uc002apc.2	+	3	343	c.195G>A	c.(193-195)GTG>GTA	p.V65V	PTPLAD1_uc002apb.1_RNA|PTPLAD1_uc010uiw.1_Silent_p.V65V	NM_016395	NP_057479	Q9P035	HACD3_HUMAN	protein tyrosine phosphatase-like A domain	65	CS.|Cytoplasmic (Potential).				activation of JUN kinase activity|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB cascade|Rac protein signal transduction	endoplasmic reticulum membrane|integral to membrane	GTPase activator activity|lyase activity|protein binding				0						TAGACCTTGTGAAACCAGAGG	0.413													0	0	0	1	0	39	115										A	65847289	G	A	65847289	2	1	65	1	0	0	0	0	0	0	0	1	12775	1277	45	1		1	PTPLAD1	15	65847289	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	349619	65847289	36684103	1045	20078										
CLN6	54982	broad.mit.edu	37	chr15	68503654	68503654	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagagcagctcaaaggagtcGatctgagggaggaacgggca	16	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:68503654G>A	uc002arf.2	-	5	647	c.489C>T	c.(487-489)ATC>ATT	p.I163I	CLN6_uc010ujy.1_Intron|CLN6_uc010ujz.1_Silent_p.I195I	NM_017882	NP_060352	Q9NWW5	CLN6_HUMAN	CLN6 protein	163					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity				0						CAAAGGAGTCGATCTGAGGGA	0.602													0	0	0	1	0	28	99										A	68503654	G	A	68503654	2	1	65	1	0	0	0	0	0	0	0	1	3545	1048	37	1		1	CLN6	15	68503654	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2656365	68503654	34027738	1046	20079										
ITGA11	22801	broad.mit.edu	37	chr15	68609618	68609618	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaaccttggccttggcccgGaagaagggatagctgacgtt	13	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:68609618G>A	uc002ari.2	-	21	2787	c.2700C>T	c.(2698-2700)TTC>TTT	p.F900F	ITGA11_uc010bib.2_Silent_p.F900F	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	900	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CCTTGGCCCGGAAGAAGGGAT	0.602													0	0	0	1	0	26	112										A	68609618	G	A	68609618	2	1	65	1	0	0	0	0	0	0	0	1	7874	1165	41	1		1	ITGA11	15	68609618	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	105964	68609618	33921774	1047	20080										
PARP6	56965	broad.mit.edu	37	chr15	72558264	72558264	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatacagagttctcactgtaGatctccttcacggcttcaat	7	11	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:72558264G>C	uc002auc.2	-	4	609	c.150C>G	c.(148-150)ATC>ATG	p.I50M	PARP6_uc002aua.2_Translation_Start_Site|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Missense_Mutation_p.I50M	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	50							NAD+ ADP-ribosyltransferase activity				0						TCTCACTGTAGATCTCCTTCA	0.498													0	0	0	1	0	15	56										C	72558264	G	C	72558264	3	2	65	1	0	0	0	0	1	0	0	0	11464	932	33	1	1822	1	PARP6	15	72558264	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3948646	72558264	29973128	1048	20081										
HCN4	10021	broad.mit.edu	37	chr15	73624577	73624577	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagagcaggagcatcatgccGatgaggttcacgatgcgcac	13	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:73624577G>A	uc002avp.2	-	3	2260	c.1266C>T	c.(1264-1266)ATC>ATT	p.I422I		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	422	Helical; Name=Segment S5; (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GCATCATGCCGATGAGGTTCA	0.592													0	0	0	1	0	16	74										A	73624577	G	A	73624577	2	1	65	1	0	0	0	0	0	0	0	1	6999	1048	37	1		1	HCN4	15	73624577	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1066313	73624577	28906815	1049	20082										
SIN3A	25942	broad.mit.edu	37	chr15	75715054	75715054	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggggctggatgagcatgactCtggaccacctggcctccgtg	15	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:75715054C>G	uc002bai.2	-	3	559	c.300G>C	c.(298-300)CAG>CAC	p.Q100H	SIN3A_uc002baj.2_Missense_Mutation_p.Q100H|SIN3A_uc010uml.1_Missense_Mutation_p.Q100H|SIN3A_uc002bak.3_Missense_Mutation_p.Q100H	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	100					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GAGCATGACTCTGGACCACCT	0.562													0	0	0	1	0	60	117										G	75715054	C	G	75715054	3	3	65	1	0	0	0	0	1	0	0	0	14325	912	32	1	3597	1	SIN3A	15	75715054	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2090477	75715054	26816338	1050	20083										
PTPN9	5780	broad.mit.edu	37	chr15	75798209	75798209	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgatctcatcgaagggatCtgggtggccgttcacctggg	15	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:75798209C>T	uc002bal.2	-	7	1283	c.775G>A	c.(775-777)GAT>AAT	p.D259N		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	259						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						TCGAAGGGATCTGGGTGGCCG	0.532													0	0	0	1	0	18	54										T	75798209	C	T	75798209	3	4	65	1	0	0	0	0	1	0	0	0	12794	913	32	1	1034	1	PTPN9	15	75798209	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	83155	75798209	26733183	1051	20084										
FBXO22	26263	broad.mit.edu	37	chr15	76196329	76196329	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccggtaggctgctgcggcGagtgccgcggctcctccgta	16	14	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:76196329G>A	uc002bbk.2	+	1	130	c.25G>A	c.(25-27)GAG>AAG	p.E9K	FBXO22_uc002bbj.1_Missense_Mutation_p.E9K|FBXO22_uc002bbl.2_5'UTR	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	9				VGCCGECR -> AGACGGP (in Ref. 5; AAF04523).	ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						CTGCTGCGGCGAGTGCCGCGG	0.677													0	0	0	1	0	5	7										A	76196329	G	A	76196329	3	1	65	1	0	0	0	0	1	0	0	0	5734	1059	37	1	27	1	FBXO22	15	76196329	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	398120	76196329	26335063	1052	20085										
SCAPER	49855	broad.mit.edu	37	chr15	76994204	76994204	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaaagatatacctctgaagaGatctgaaagcacaaaatcaa	6	7	3	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:76994204G>A	uc002bby.2	-	19	2462	c.2403C>T	c.(2401-2403)ATC>ATT	p.I801I	SCAPER_uc010bkr.2_Silent_p.I109I|SCAPER_uc002bbx.2_Silent_p.I555I|SCAPER_uc002bbz.1_Silent_p.I672I|SCAPER_uc002bca.1_Silent_p.I666I	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	800	C2H2-type.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						CCTCTGAAGAGATCTGAAAGC	0.378													0	0	0	1	0	8	31										A	76994204	G	A	76994204	2	1	65	1	0	0	0	0	0	0	0	1	13878	932	33	1		1	SCAPER	15	76994204	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	797875	76994204	25537188	1053	20086										
CRABP1	1381	broad.mit.edu	37	chr15	78635840	78635840	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taatggttttcccgcctgcaGagtttagccacttgggagaa	11	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:78635840G>A	uc002bdp.2	+	3	355	c.250_splice	c.e3-1	p.S84_splice		NM_004378	NP_004369	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1						multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity				0					Alitretinoin(DB00523)|Etretinate(DB00926)	CCCGCCTGCAGAGTTTAGCCA	0.493													0	0	0	1	0	8	46										A	78635840	G	A	78635840	5	1	65	1	0	0	0	0	0	0	1	0	3843	956	33	1	259	1	CRABP1	15	78635840	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1641636	78635840	23895552	1054	20087										
KIAA1199	57214	broad.mit.edu	37	chr15	81199101	81199101	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacatcatagtgatgggggaGatggaggacaaatgctaccc	13	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:81199101G>A	uc002bfw.1	+	12	1769	c.1509G>A	c.(1507-1509)GAG>GAA	p.E503E	KIAA1199_uc010unn.1_Silent_p.E503E	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	503										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TGATGGGGGAGATGGAGGACA	0.527													0	0	0	1	0	19	62										A	81199101	G	A	81199101	2	1	65	1	0	0	0	0	0	0	0	1	8213	933	33	1		1	KIAA1199	15	81199101	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2563261	81199101	21332291	1055	20088										
TMC3	342125	broad.mit.edu	37	chr15	81660670	81660670	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcacaatgttcttcgcttgtCtaagagaagaaaaacatgat	8	7	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:81660670C>T	uc002bgo.1	-	3	237	c.237_splice	c.e3-1	p.R79_splice	TMC3_uc010blr.1_Splice_Site|TMC3_uc002bgp.2_Splice_Site_p.R79_splice	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3							integral to membrane				ovary(1)|liver(1)	2						CTTCGCTTGTCTAAGAGAAGA	0.423													0	0	0	1	0	58	195										T	81660670	C	T	81660670	5	4	65	1	0	0	0	0	0	0	1	0	15983	927	32	1	3146	1	TMC3	15	81660670	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	461569	81660670	20870722	1056	20089										
ACAN	176	broad.mit.edu	37	chr15	89400090	89400090	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctagagactactgcccctgGagtagatgagatcagtgggc	13	9	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:89400090G>C	uc010upo.1	+	12	4648	c.4274G>C	c.(4273-4275)GGA>GCA	p.G1425A	ACAN_uc010upp.1_Missense_Mutation_p.G1425A|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1425					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			ACTGCCCCTGGAGTAGATGAG	0.532													0	0	0	1	0	73	202										C	89400090	G	C	89400090	3	2	65	1	0	0	0	0	1	0	0	0	117	1174	41	1	4316	1	ACAN	15	89400090	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7739420	89400090	13131302	1057	20090										
ACAN	176	broad.mit.edu	37	chr15	89417171	89417171	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtgcggtaccagtgcacaGaggggtttgtccagcgccac	15	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:89417171G>C	uc010upo.1	+	17	7806	c.7432G>C	c.(7432-7434)GAG>CAG	p.E2478Q	ACAN_uc010upp.1_Intron|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2478					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCAGTGCACAGAGGGGTTTGT	0.642													0	0	0	1	0	8	39										C	89417171	G	C	89417171	3	2	65	1	0	0	0	0	1	0	0	0	117	943	33	1	7494	1	ACAN	15	89417171	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	17081	89417171	13114221	1058	20091										
ACAN	176	broad.mit.edu	37	chr15	89417256	89417256	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagatcacctgcacagaccGtgagcatcaccccggccatc	8	17	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:89417256G>T	uc010upo.1	+	17	7890	c.7516_splice	c.e17+1	p.P2506_splice	ACAN_uc010upp.1_Intron|ACAN_uc002bna.2_Splice_Site	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor						cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGCACAGACCGTGAGCATCAC	0.657													1	0	3.27435e-08	1	3.40091e-08	15	36										T	89417256	G	T	89417256	5	4	65	1	0	0	0	0	0	0	1	0	117	1159	40	4	7579	4	ACAN	15	89417256	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	85	89417256	13114136	1059	20092										
CHD2	1106	broad.mit.edu	37	chr15	93527668	93527668	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggaaaaaagtagaggaggaaGagcggcagaaggagctagaa	17	3	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr15:93527668G>C	uc002bsp.2	+	25	3750	c.3175G>C	c.(3175-3177)GAG>CAG	p.E1059Q	CHD2_uc002bso.1_Missense_Mutation_p.E1059Q	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1059	Glu-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGAGGAGGAAGAGCGGCAGAA	0.408													0	0	0	1	0	4	26										C	93527668	G	C	93527668	3	2	65	1	0	0	0	0	1	0	0	0	3325	943	33	1	3273	1	CHD2	15	93527668	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4110412	93527668	9003724	1060	20093										
CEMP1	752014	broad.mit.edu	37	chr16	2581056	2581056	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgcccagcttgctggctgtCagtgcttgatgtgcccatcc	12	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:2581056C>T	uc002cqr.2	-	1	375	c.19G>A	c.(19-21)GAC>AAC	p.D7N		NM_001048212	NP_001041677	Q6PRD7	CEMP1_HUMAN	cementum protein 1	7						cytoplasm				skin(1)	1						TGCTGGCTGTCAGTGCTTGAT	0.617													0	0	0	1	0	16	73										T	2581056	C	T	2581056	3	4	65	1	0	0	0	0	1	0	0	0	3224	826	29	1	728	1	CEMP1	16	2581056	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		2581056	87773697	1061	20094										
CLDN6	9074	broad.mit.edu	37	chr16	3065463	3065463	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggggccctgggacccccccGaggggcaagtgcagcacagc	16	15	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:3065463G>T	uc002csu.3	-	2	620	c.560C>A	c.(559-561)TCG>TAG	p.S187*		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	187	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GGACCCCCCCGAGGGGCAAGT	0.652													1	0	1.37285e-15	1	1.44903e-15	16	53										T	3065463	G	T	3065463	4	4	65	1	0	0	0	0	0	1	0	0	3489	1059	37	3	106	3	CLDN6	16	3065463	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	484407	3065463	87289290	1062	20095										
ZSCAN10	84891	broad.mit.edu	37	chr16	3139503	3139503	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgcgccaggtgggcgctctgGctgaagccctcaccgcactc	13	17	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:3139503G>A	uc002ctv.1	-	5	1855	c.1767C>T	c.(1765-1767)AGC>AGT	p.S589S	ZSCAN10_uc002cty.1_Silent_p.S250S|ZSCAN10_uc002ctw.1_Silent_p.S507S|ZSCAN10_uc002ctx.1_Silent_p.S517S	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	589	C2H2-type 10.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GGGCGCTCTGGCTGAAGCCCT	0.697													0	0	0	1	0	10	43										A	3139503	G	A	3139503	2	1	65	1	0	0	0	0	0	0	0	1	18224	1194	42	2		2	ZSCAN10	16	3139503	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	74040	3139503	87215250	1063	20096										
C16orf90	646174	broad.mit.edu	37	chr16	3543964	3543964	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgggggagggcacccttgtCtgggtccatgctggaactgg	17	10	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:3543964C>G	uc002cvi.2	-	3	424	c.424G>C	c.(424-426)GAC>CAC	p.D142H		NM_001080524	NP_001073993	A8MZG2	CP090_HUMAN	hypothetical protein LOC646174	132											0						GCACCCTTGTCTGGGTCCATG	0.632													0	0	0	1	0	11	17										G	3543964	C	G	3543964	3	3	65	1	0	0	0	0	1	0	0	0	1843	913	32	1	128	1	C16orf90	16	3543964	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	404461	3543964	86810789	1064	20097										
MGRN1	23295	broad.mit.edu	37	chr16	4674988	4674988	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccattctcagccgccgcatCgcgggggtggaggacatcga	14	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:4674988C>G	uc002cwz.2	+	1	163	c.27C>G	c.(25-27)ATC>ATG	p.I9M	MGRN1_uc002cxa.2_Missense_Mutation_p.I9M|MGRN1_uc010btx.2_Missense_Mutation_p.I9M|MGRN1_uc010btw.2_Missense_Mutation_p.I9M|MGRN1_uc002cxb.2_Missense_Mutation_p.I9M|MGRN1_uc010uxo.1_Missense_Mutation_p.I9M|MGRN1_uc010uxp.1_Missense_Mutation_p.I9M|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	9					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GCCGCCGCATCGCGGGGGTGG	0.736													0	0	0	1	0	3	14										G	4674988	C	G	4674988	3	3	65	1	0	0	0	0	1	0	0	0	9559	874	31	1	29	1	MGRN1	16	4674988	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1131024	4674988	85679765	1065	20098										
PPL	5493	broad.mit.edu	37	chr16	4945714	4945714	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcgtccttcacgtcttcgtGaaactaggggagaaggtggc	14	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:4945714G>A	uc002cyd.1	-	10	1066	c.976C>T	c.(976-978)CAC>TAC	p.H326Y		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	326	Potential.|Spectrin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						ACGTCTTCGTGAAACTAGGGG	0.582													0	0	0	1	0	38	97										A	4945714	G	A	4945714	3	1	65	1	0	0	0	0	1	0	0	0	12334	1290	45	1	4346	1	PPL	16	4945714	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	270726	4945714	85409039	1066	20099										
USP7	7874	broad.mit.edu	37	chr16	8997182	8997182	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaggagttcttcaatactttGaacacagtgtatttcacttt	7	7	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:8997182G>C	uc002czl.2	-	16	1981	c.1782C>G	c.(1780-1782)TTC>TTG	p.F594L	USP7_uc010uyk.1_Missense_Mutation_p.F495L|USP7_uc002czj.2_RNA|USP7_uc010uyj.1_Missense_Mutation_p.F495L|USP7_uc002czk.2_Missense_Mutation_p.F578L|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	594					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						TCAATACTTTGAACACAGTGT	0.473													0	0	0	1	0	14	57										C	8997182	G	C	8997182	3	2	65	1	0	0	0	0	1	0	0	0	17085	1281	45	1	1590	1	USP7	16	8997182	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4051468	8997182	81357571	1067	20100										
RRN3	54700	broad.mit.edu	37	chr16	15157071	15157071	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acctttttcatgggtttcttGaactcctgtagctcttcagc	7	11	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:15157071G>C	uc002dde.2	-	17	1844	c.1776C>G	c.(1774-1776)TTC>TTG	p.F592L	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Missense_Mutation_p.F460L|RRN3_uc010uzq.1_Missense_Mutation_p.F562L	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	592	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						TGGGTTTCTTGAACTCCTGTA	0.403													0	0	0	1	0	33	115										C	15157071	G	C	15157071	3	2	65	1	0	0	0	0	1	0	0	0	13684	1281	45	1	187	1	RRN3	16	15157071	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6159889	15157071	75197682	1068	20101										
KIAA0430	9665	broad.mit.edu	37	chr16	15718642	15718642	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcacctagaagaccaagactGagatgcgagcagaggactga	12	9	1	6			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:15718642G>A	uc002ddr.2	-	10	2447	c.2254C>T	c.(2254-2256)CAG>TAG	p.Q752*	KIAA0430_uc002ddq.2_Nonsense_Mutation_p.Q608*|KIAA0430_uc010uzv.1_Nonsense_Mutation_p.Q748*|KIAA0430_uc010uzw.1_Nonsense_Mutation_p.Q750*	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	751						peroxisome	nucleotide binding|RNA binding				0						GACCAAGACTGAGATGCGAGC	0.393													0	0	0	1	0	28	97										A	15718642	G	A	15718642	4	1	65	1	0	0	0	0	0	1	0	0	8177	1299	45	1	3049	1	KIAA0430	16	15718642	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	561571	15718642	74636111	1069	20102										
MYH11	4629	broad.mit.edu	37	chr16	15835629	15835629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaggtacctgcgagtgcttCtgttccagctccttaagctc	9	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:15835629C>T	uc002ddy.2	-	21	2747	c.2640G>A	c.(2638-2640)CAG>CAA	p.Q880Q	MYH11_uc002ddv.2_Silent_p.Q887Q|MYH11_uc002ddw.2_Silent_p.Q880Q|MYH11_uc002ddx.2_Silent_p.Q887Q|MYH11_uc010bvg.2_Silent_p.Q712Q	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	880	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GCGAGTGCTTCTGTTCCAGCT	0.612			T	CBFB	AML								0	0	0	1	0	86	245										T	15835629	C	T	15835629	2	4	65	1	0	0	0	0	0	0	0	1	10031	912	32	1		1	MYH11	16	15835629	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	116987	15835629	74519124	1070	20103										
ABCC1	4363	broad.mit.edu	37	chr16	16184358	16184358	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctctgagatgggctcctacCaggagctgctggctcgagac	13	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:16184358C>T	uc010bvi.2	+	19	2732	c.2557C>T	c.(2557-2559)CAG>TAG	p.Q853*	ABCC1_uc010bvj.2_Nonsense_Mutation_p.Q794*|ABCC1_uc010bvk.2_Nonsense_Mutation_p.Q797*|ABCC1_uc010bvl.2_Nonsense_Mutation_p.Q853*|ABCC1_uc010bvm.2_Nonsense_Mutation_p.Q738*|ABCC1_uc002del.3_Nonsense_Mutation_p.Q737*	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	853	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGGCTCCTACCAGGAGCTGCT	0.607													0	0	0	1	0	8	37										T	16184358	C	T	16184358	4	4	65	1	0	0	0	0	0	1	0	0	49	595	21	2	2631	2	ABCC1	16	16184358	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	348729	16184358	74170395	1071	20104										
XYLT1	64131	broad.mit.edu	37	chr16	17211612	17211612	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actgtccagaccccaggcctCaggggcaagttcaaaggggg	14	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:17211612C>T	uc002dfa.2	-	11	2533	c.2448G>A	c.(2446-2448)CTG>CTA	p.L816L		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	816	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CCCCAGGCCTCAGGGGCAAGT	0.552													0	0	0	1	0	13	77										T	17211612	C	T	17211612	2	4	65	1	0	0	0	0	0	0	0	1	17460	813	29	1		1	XYLT1	16	17211612	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1027254	17211612	73143141	1072	20105										
ERN2	10595	broad.mit.edu	37	chr16	23703600	23703600	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaaggggtggctgccaccaGaaagcacgtagtagaacacg	13	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:23703600G>C	uc002dma.3	-	18	2466	c.2297C>G	c.(2296-2298)TCT>TGT	p.S766C	ERN2_uc010bxp.2_Missense_Mutation_p.S714C	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	718	Protein kinase.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCTGCCACCAGAAAGCACGTA	0.567													0	0	0	1	0	32	104										C	23703600	G	C	23703600	3	2	65	1	0	0	0	0	1	0	0	0	5238	942	33	1	647	1	ERN2	16	23703600	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6491988	23703600	66651153	1073	20106										
CHP2	63928	broad.mit.edu	37	chr16	23767007	23767007	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caagccagcctgctccgcctGcaccaccggttccgggcact	10	19	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:23767007G>A	uc002dmb.1	+	2	516	c.93G>A	c.(91-93)CTG>CTA	p.L31L		NM_022097	NP_071380	O43745	CHP2_HUMAN	hepatocellular carcinoma antigen gene 520	31	EF-hand 1.						calcium ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(48;0.0144)		TGCTCCGCCTGCACCACCGGT	0.637													0	0	0	1	0	22	87										A	23767007	G	A	23767007	2	1	65	1	0	0	0	0	0	0	0	1	3367	1306	46	2		2	CHP2	16	23767007	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	63407	23767007	66587746	1074	20107										
GTF3C1	2975	broad.mit.edu	37	chr16	27544708	27544708	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggatgtcgtatttgctcctCctgcaagaaacaccgagcaa	9	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:27544708C>T	uc002dov.1	-	5	793	c.753G>A	c.(751-753)AGG>AGA	p.R251R	GTF3C1_uc002dou.2_Silent_p.R251R	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	251						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ATTTGCTCCTCCTGCAAGAAA	0.448													0	0	0	1	0	21	57										T	27544708	C	T	27544708	2	4	65	1	0	0	0	0	0	0	0	1	6872	869	30	1		1	GTF3C1	16	27544708	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3777701	27544708	62810045	1075	20108										
XPO6	23214	broad.mit.edu	37	chr16	28167708	28167708	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggggtgatgctggcagacaGaggaatccaactgaagagat	15	6	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:28167708G>T	uc002dpa.1	-	7	1285	c.784C>A	c.(784-786)CTG>ATG	p.L262M	XPO6_uc002dpb.1_Missense_Mutation_p.L248M|XPO6_uc010vcp.1_Missense_Mutation_p.L262M	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	262					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						CTGGCAGACAGAGGAATCCAA	0.517													1	0	2.37509e-13	1	2.49598e-13	22	92										T	28167708	G	T	28167708	3	4	65	1	0	0	0	0	1	0	0	0	17445	933	33	3	2665	3	XPO6	16	28167708	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	623000	28167708	62187045	1076	20109										
SULT1A2	6799	broad.mit.edu	37	chr16	28603660	28603660	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagttggtcatagggttcttCttcatctccttgaacgacgt	9	9	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:28603660C>T	uc002dqg.1	-	7	1050	c.699G>A	c.(697-699)AAG>AAA	p.K233K	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Silent_p.K233K	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	233					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						TAGGGTTCTTCTTCATCTCCT	0.567													0	0	0	1	0	46	182										T	28603660	C	T	28603660	2	4	65	1	0	0	0	0	0	0	0	1	15372	912	32	1		1	SULT1A2	16	28603660	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	435952	28603660	61751093	1077	20110										
SH2B1	25970	broad.mit.edu	37	chr16	28883708	28883708	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acgtcctcaccttcaacttcCagggcaaggccaaggtgagc	10	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:28883708C>T	uc002dri.2	+	9	2150	c.1711C>T	c.(1711-1713)CAG>TAG	p.Q571*	uc010vct.1_Intron|SH2B1_uc010vdc.1_Nonsense_Mutation_p.Q261*|SH2B1_uc002drj.2_Nonsense_Mutation_p.Q571*|SH2B1_uc002drk.2_Nonsense_Mutation_p.Q571*|SH2B1_uc002drl.2_Nonsense_Mutation_p.Q571*|SH2B1_uc010vdd.1_Nonsense_Mutation_p.Q235*|SH2B1_uc010vde.1_Nonsense_Mutation_p.Q571*|SH2B1_uc002drm.2_Nonsense_Mutation_p.Q571*	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	571	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						CTTCAACTTCCAGGGCAAGGC	0.617													0	0	0	1	0	20	60										T	28883708	C	T	28883708	4	4	65	1	0	0	0	0	0	1	0	0	14227	595	21	2	1733	2	SH2B1	16	28883708	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	280048	28883708	61471045	1078	20111										
SRCAP	10847	broad.mit.edu	37	chr16	30750601	30750601	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaggaatgcgaggacggaaGagtggagggtccatggtggt	20	4	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:30750601G>C	uc002dze.1	+	34	9625	c.9240G>C	c.(9238-9240)AAG>AAC	p.K3080N	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.K2875N	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	3080					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GAGGACGGAAGAGTGGAGGGT	0.587													0	0	0	1	0	16	48										C	30750601	G	C	30750601	3	2	65	1	0	0	0	0	1	0	0	0	15134	933	33	1	9366	1	SRCAP	16	30750601	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1866893	30750601	59604152	1079	20112										
ZNF646	9726	broad.mit.edu	37	chr16	31087769	31087769	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accaggacagtgaggaggctGacagcatccctcggccctac	12	14	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:31087769G>A	uc002eap.2	+	2	413	c.124G>A	c.(124-126)GAC>AAC	p.D42N	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	42					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TGAGGAGGCTGACAGCATCCC	0.632													0	0	0	1	0	48	117										A	31087769	G	A	31087769	3	1	65	1	0	0	0	0	1	0	0	0	18059	1290	45	1	126	1	ZNF646	16	31087769	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	337168	31087769	59266984	1080	20113										
ITGAM	3684	broad.mit.edu	37	chr16	31283172	31283172	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccgccccctccgcagttctCtttgatgcagtactctgaag	9	15	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:31283172C>G	uc002ebq.2	+	7	661	c.563C>G	c.(562-564)TCT>TGT	p.S188C	ITGAM_uc002ebr.2_Missense_Mutation_p.S188C	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	188	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CCGCAGTTCTCTTTGATGCAG	0.517													0	0	0	1	0	16	46										G	31283172	C	G	31283172	3	3	65	1	0	0	0	0	1	0	0	0	7887	913	32	1	589	1	ITGAM	16	31283172	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	195403	31283172	59071581	1081	20114										
VPS35	55737	broad.mit.edu	37	chr16	46694412	46694412	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgagaccttcataaattggcCcctcggattctggtgattcc	9	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:46694412C>T	uc002eef.3	-	17	2462	c.2363G>A	c.(2362-2364)GGG>GAG	p.G788E	VPS35_uc002eed.2_3'UTR|VPS35_uc002eee.2_Missense_Mutation_p.G749E	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	788					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				ATAAATTGGCCCCTCGGATTC	0.438													0	0	0	1	0	20	84										T	46694412	C	T	46694412	3	4	65	1	0	0	0	0	1	0	0	0	17200	623	22	2	31	2	VPS35	16	46694412	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	15411240	46694412	43660341	1082	20115										
ABCC12	94160	broad.mit.edu	37	chr16	48162609	48162609	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtatctgggtcttctggttGggtgatgtaagatggggggc	18	4	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:48162609G>A	uc002efc.1	-	9	1622	c.1276C>T	c.(1276-1278)CAA>TAA	p.Q426*	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Nonsense_Mutation_p.Q426*	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	426						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TCTTCTGGTTGGGTGATGTAA	0.413													0	0	0	1	0	27	90										A	48162609	G	A	48162609	4	1	65	1	0	0	0	0	0	1	0	0	52	1357	47	2	2887	2	ABCC12	16	48162609	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1468197	48162609	42192144	1083	20116										
LONP2	83752	broad.mit.edu	37	chr16	48290643	48290643	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atccgaacaagcaacaaagaGaaactccaggtacagtgttc	8	10	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:48290643G>A	uc002efi.1	+	3	680	c.591G>A	c.(589-591)GAG>GAA	p.E197E	LONP2_uc010vgm.1_Intron|LONP2_uc002efj.1_Intron	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	197	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						GCAACAAAGAGAAACTCCAGG	0.393													0	0	0	1	0	15	55										A	48290643	G	A	48290643	2	1	65	1	0	0	0	0	0	0	0	1	8893	933	33	1		1	LONP2	16	48290643	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	128034	48290643	42064110	1084	20117										
CHD9	80205	broad.mit.edu	37	chr16	53352146	53352146	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatgcagcttcatgagggaaGacccaaacaaaaaagacacc	8	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:53352146G>A	uc002ehb.2	+	36	7771	c.7607G>A	c.(7606-7608)AGA>AAA	p.R2536K	CHD9_uc002egy.2_Missense_Mutation_p.R2520K|CHD9_uc002ehc.2_Missense_Mutation_p.R2521K|CHD9_uc002ehf.2_Missense_Mutation_p.R1634K|CHD9_uc010cbw.2_Missense_Mutation_p.R602K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2536					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CATGAGGGAAGACCCAAACAA	0.338													0	0	0	1	0	3	22										A	53352146	G	A	53352146	3	1	65	1	0	0	0	0	1	0	0	0	3332	942	33	1	7701	1	CHD9	16	53352146	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	5061503	53352146	37002607	1085	20118										
CAPNS2	84290	broad.mit.edu	37	chr16	55601337	55601337	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgccatgtttcgtgccttCaagtctctggatagagatag	11	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:55601337C>G	uc002eid.1	+	1	754	c.669C>G	c.(667-669)TTC>TTG	p.F223L	LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706	Q96L46	CPNS2_HUMAN	calpain small subunit 2	223	EF-hand 4.					cytoplasm|plasma membrane	calcium ion binding				0						TTCGTGCCTTCAAGTCTCTGG	0.443													0	0	0	1	0	58	153										G	55601337	C	G	55601337	3	3	65	1	0	0	0	0	1	0	0	0	2634	825	29	1	671	1	CAPNS2	16	55601337	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2249191	55601337	34753416	1086	20119										
OGFOD1	55239	broad.mit.edu	37	chr16	56485527	56485527	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgtgccttgggaagagatGaatgggaagcggccagcgga	17	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:56485527G>T	uc002ejb.2	+	1	104	c.3G>T	c.(1-3)ATG>ATT	p.M1I	OGFOD1_uc002ejc.2_Intron|NUDT21_uc002eja.2_5'Flank	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	1							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	GGGAAGAGATGAATGGGAAGC	0.587													1	0	5.20006e-24	1	5.54389e-24	42	177										T	56485527	G	T	56485527	3	4	65	1	0	0	0	0	1	0	0	0	10841	1290	45	3	5	3	OGFOD1	16	56485527	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	884190	56485527	33869226	1087	20120										
HERPUD1	9709	broad.mit.edu	37	chr16	56970630	56970630	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacagaggagcctgctggttCtaatcggggacagtatcctg	13	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:56970630C>G	uc002eke.1	+	4	741	c.332C>G	c.(331-333)TCT>TGT	p.S111C	HERPUD1_uc010vhj.1_Missense_Mutation_p.S172C|HERPUD1_uc002ekf.1_Missense_Mutation_p.S110C|HERPUD1_uc002ekg.1_Missense_Mutation_p.S86C|HERPUD1_uc010cco.1_Missense_Mutation_p.S172C|HERPUD1_uc010ccp.1_Missense_Mutation_p.S171C|HERPUD1_uc002ekh.1_5'UTR	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	111	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						CCTGCTGGTTCTAATCGGGGA	0.453			T	ERG	prostate								0	0	0	1	0	14	53										G	56970630	C	G	56970630	3	3	65	1	0	0	0	0	1	0	0	0	7063	913	32	1	346	1	HERPUD1	16	56970630	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	485103	56970630	33384123	1088	20121										
GPR97	222487	broad.mit.edu	37	chr16	57710248	57710248	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atttctctctggagccctctCaggtgaagagctccccagcc	9	15	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:57710248C>T	uc002emh.2	+	3	446	c.343C>T	c.(343-345)CAG>TAG	p.Q115*	GPR97_uc010cdc.2_Nonsense_Mutation_p.Q115*|GPR97_uc010vhv.1_Intron|GPR97_uc010cdd.2_RNA	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	115	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GGAGCCCTCTCAGGTGAAGAG	0.473													0	0	0	1	0	23	67										T	57710248	C	T	57710248	4	4	65	1	0	0	0	0	0	1	0	0	6720	827	29	1	353	1	GPR97	16	57710248	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	739618	57710248	32644505	1089	20122										
RLTPR	146206	broad.mit.edu	37	chr16	67681650	67681650	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagactcagcctggcccaGacagggttgacaccgcgagg	15	12	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:67681650G>C	uc002etn.2	+	12	1059	c.939G>C	c.(937-939)CAG>CAC	p.Q313H	RLTPR_uc010cel.1_Missense_Mutation_p.Q313H|RLTPR_uc010vjr.1_Missense_Mutation_p.Q313H	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	313	LRR 5.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GCCTGGCCCAGACAGGGTTGA	0.657													0	0	0	1	0	4	12										C	67681650	G	C	67681650	3	2	65	1	0	0	0	0	1	0	0	0	13394	933	33	1	985	1	RLTPR	16	67681650	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9971402	67681650	22673103	1090	20123										
RLTPR	146206	broad.mit.edu	37	chr16	67683002	67683002	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcggctcagacatggtgactCtggtgctggccatcgggaga	15	10	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:67683002C>G	uc002etn.2	+	18	1735	c.1615C>G	c.(1615-1617)CTG>GTG	p.L539V	RLTPR_uc010cel.1_Missense_Mutation_p.L532V|RLTPR_uc010vjr.1_Missense_Mutation_p.L503V	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	539	LRR 11.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CATGGTGACTCTGGTGCTGGC	0.617													0	0	0	1	0	14	25										G	67683002	C	G	67683002	3	3	65	1	0	0	0	0	1	0	0	0	13394	912	32	1	1685	1	RLTPR	16	67683002	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1352	67683002	22671751	1091	20124										
NUTF2	10204	broad.mit.edu	37	chr16	67899100	67899100	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aacattactaccagttatttGataatgatagaacccaacta	4	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:67899100G>C	uc002eup.2	+	2	166	c.67G>C	c.(67-69)GAT>CAT	p.D23H	NUTF2_uc010vkf.1_Missense_Mutation_p.D23H	NM_005796	NP_005787	P61970	NTF2_HUMAN	nuclear transport factor 2	23	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)		CCAGTTATTTGATAATGATAG	0.493													0	0	0	1	0	16	49										C	67899100	G	C	67899100	3	2	65	1	0	0	0	0	1	0	0	0	10779	1290	45	1	69	1	NUTF2	16	67899100	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	216098	67899100	22455653	1092	20125										
PRMT7	54496	broad.mit.edu	37	chr16	68386284	68386284	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgatgccccaggcagcctCgctgcacgctgtggttgtgg	16	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:68386284C>T	uc002evy.1	+	15	1823	c.1547C>T	c.(1546-1548)TCG>TTG	p.S516L	PRMT7_uc002evx.1_Missense_Mutation_p.S442L|PRMT7_uc010vlg.1_Missense_Mutation_p.S466L|PRMT7_uc002evz.1_Missense_Mutation_p.S288L|PRMT7_uc010cfd.1_Missense_Mutation_p.S8L	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	516					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CAGGCAGCCTCGCTGCACGCT	0.617													0	0	0	1	0	27	81										T	68386284	C	T	68386284	3	4	65	1	0	0	0	0	1	0	0	0	12541	893	31	1	1597	1	PRMT7	16	68386284	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	487184	68386284	21968469	1093	20126										
CDH3	1001	broad.mit.edu	37	chr16	68721569	68721569	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacaaggacctgtctccccaCacctcccctttccaggccca	6	20	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:68721569C>T	uc002ewf.2	+	12	2857	c.1725C>T	c.(1723-1725)CAC>CAT	p.H575H	CDH3_uc010vli.1_Silent_p.H520H	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	575	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		TGTCTCCCCACACCTCCCCTT	0.597													0	0	0	1	0	23	91										T	68721569	C	T	68721569	2	4	65	1	0	0	0	0	0	0	0	1	3111	477	17	2		2	CDH3	16	68721569	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	335285	68721569	21633184	1094	20127										
TMCO7	79613	broad.mit.edu	37	chr16	68961944	68961944	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctttcccactggatagagcaGagagaagcaaaagcccttga	10	10	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:68961944G>C	uc002ewi.3	+	13	2613	c.2601G>C	c.(2599-2601)CAG>CAC	p.Q867H		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	867						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		GGATAGAGCAGAGAGAAGCAA	0.463													0	0	0	1	0	5	9										C	68961944	G	C	68961944	3	2	65	1	0	0	0	0	1	0	0	0	15998	933	33	1	2651	1	TMCO7	16	68961944	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	240375	68961944	21392809	1095	20128										
HYDIN	54768	broad.mit.edu	37	chr16	70975573	70975573	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttggctttctcctgggccttCatggctgcgtaatcctgggc	12	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:70975573C>T	uc002ezr.2	-	43	6944	c.6816G>A	c.(6814-6816)ATG>ATA	p.M2272I		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2273	Potential.									ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCTGGGCCTTCATGGCTGCGT	0.527													0	0	0	1	0	30	119										T	70975573	C	T	70975573	3	4	65	1	0	0	0	0	1	0	0	0	7467	826	29	1	8722	1	HYDIN	16	70975573	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2013629	70975573	19379180	1096	20129										
TAT	6898	broad.mit.edu	37	chr16	71610277	71610277	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcacgtccagaattgagggGaggttgcctttgctgctcat	13	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:71610277G>C	uc002fap.2	-	2	141	c.42C>G	c.(40-42)CTC>CTG	p.L14L	TAT_uc002faq.2_Silent_p.L14L|TAT_uc002far.2_Silent_p.L14L	NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	14					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GAATTGAGGGGAGGTTGCCTT	0.527													0	0	0	1	0	20	76										C	71610277	G	C	71610277	2	2	65	1	0	0	0	0	0	0	0	1	15587	1161	41	1		1	TAT	16	71610277	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	634704	71610277	18744476	1097	20130										
PHLPP2	23035	broad.mit.edu	37	chr16	71718466	71718466	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttgggctcctgctgagctGaaagcaagggagtattgccg	15	9	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:71718466G>A	uc002fax.2	-	4	654	c.648C>T	c.(646-648)TTC>TTT	p.F216F	PHLPP2_uc002fav.2_5'Flank|PHLPP2_uc010cgf.2_Silent_p.F216F|PHLPP2_uc002fay.1_Silent_p.F216F	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	216	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CTGCTGAGCTGAAAGCAAGGG	0.468													0	0	0	1	0	22	77										A	71718466	G	A	71718466	2	1	65	1	0	0	0	0	0	0	0	1	11855	1281	45	1		1	PHLPP2	16	71718466	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	108189	71718466	18636287	1098	20131										
HP	3240	broad.mit.edu	37	chr16	72094738	72094738	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctgagtatggtgtgtatgtGaaggtgacttccatccagga	14	6	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:72094738G>A	uc002fbr.3	+	7	1214	c.1170G>A	c.(1168-1170)GTG>GTA	p.V390V	TXNL4B_uc010cgl.2_Intron|HP_uc010cgm.2_Silent_p.V331V|HP_uc002fbt.3_Silent_p.V331V|HP_uc002fbu.1_Silent_p.V128V|HP_uc002fbv.3_Silent_p.V301V|HP_uc002fbw.3_Silent_p.V212V|HP_uc002fbx.3_Silent_p.V212V|HPR_uc002fby.2_5'Flank	NM_005143	NP_005134	P00738	HPT_HUMAN	haptoglobin isoform 1 preproprotein	390	Peptidase S1.				cellular iron ion homeostasis|defense response|negative regulation of hydrogen peroxide catabolic process|negative regulation of oxidoreductase activity|positive regulation of cell death|proteolysis|response to hydrogen peroxide	extracellular region|haptoglobin-hemoglobin complex	hemoglobin binding|serine-type endopeptidase activity				0		Renal(780;9.67e-05)|Ovarian(137;0.00327)|Hepatocellular(780;0.114)		BRCA - Breast invasive adenocarcinoma(221;0.00015)|Kidney(780;0.000529)		GTGTGTATGTGAAGGTGACTT	0.522													0	0	0	1	0	37	131										A	72094738	G	A	72094738	2	1	65	1	0	0	0	0	0	0	0	1	7327	1277	45	1		1	HP	16	72094738	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	376272	72094738	18260015	1099	20132										
ZFHX3	463	broad.mit.edu	37	chr16	72828402	72828402	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acgggaccggatatgagcctCaagagcagtcttggctttga	13	9	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:72828402C>A	uc002fck.2	-	9	8852	c.8179G>T	c.(8179-8181)GAG>TAG	p.E2727*	ZFHX3_uc002fcl.2_Nonsense_Mutation_p.E1813*	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2727	C2H2-type 20.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				ATATGAGCCTCAAGAGCAGTC	0.562													1	0	9.90768e-06	1	1.01352e-05	26	87										A	72828402	C	A	72828402	4	1	65	1	0	0	0	0	0	1	0	0	17631	835	29	3	2940	3	ZFHX3	16	72828402	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	733664	72828402	17526351	1100	20133										
CNTNAP4	85445	broad.mit.edu	37	chr16	76587302	76587302	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctctgcaccccagccacccaGaccctgtcactgttacagga	7	18	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:76587302G>A	uc002feu.1	+	24	3950	c.3565G>A	c.(3565-3567)GAC>AAC	p.D1189N	CNTNAP4_uc002fev.1_Missense_Mutation_p.D1053N|CNTNAP4_uc010chb.1_Missense_Mutation_p.D1116N|CNTNAP4_uc002fex.1_Missense_Mutation_p.D1192N	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1189	Extracellular (Potential).|Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CAGCCACCCAGACCCTGTCAC	0.607													0	0	0	1	0	7	23										A	76587302	G	A	76587302	3	1	65	1	0	0	0	0	1	0	0	0	3649	942	33	1	3664	1	CNTNAP4	16	76587302	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3758900	76587302	13767451	1101	20134										
ADAMTS18	170692	broad.mit.edu	37	chr16	77353980	77353980	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagctggaatgaggaccacCggataatattctaaatggaa	10	8	1	1	rs149346461	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:77353980C>T	uc002ffc.3	-	16	2717	c.2298G>A	c.(2296-2298)CCG>CCA	p.P766P	ADAMTS18_uc010chc.1_Silent_p.P354P|ADAMTS18_uc002ffe.1_Silent_p.P462P	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	766	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGAGGACCACCGGATAATATT	0.473													0	0	0	1	0	6	67										T	77353980	C	T	77353980	2	4	65	1	0	0	0	0	0	0	0	1	263	639	23	2		2	ADAMTS18	16	77353980	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	766678	77353980	13000773	1102	20135										
MAF	4094	broad.mit.edu	37	chr16	79633490	79633490	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggggctgaagcccagcgcctCggggttcagctgctgcgggt	18	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:79633490C>T	uc002ffn.2	-	1	1133	c.310G>A	c.(310-312)GAG>AAG	p.E104K	MAF_uc002ffm.2_Missense_Mutation_p.E104K	NM_001031804	NP_001026974	O75444	MAF_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	104					transcription from RNA polymerase II promoter	chromatin|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_epithelial(2;0.139)|Lung NSC(2;0.186)|Melanoma(2;0.211)		UCEC - Uterine corpus endometrioid carcinoma (2;0.0178)		CCCAGCGCCTCGGGGTTCAGC	0.706			T	IGH@	MM								0	0	0	1	0	4	20										T	79633490	C	T	79633490	3	4	65	1	0	0	0	0	1	0	0	0	9155	893	31	1	913	1	MAF	16	79633490	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2279510	79633490	10721263	1103	20136										
C16orf46	123775	broad.mit.edu	37	chr16	81095596	81095596	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atccttctctgggcccccctCagtaggaggcttggtctgga	12	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:81095596C>T	uc002fgc.3	-	4	617	c.358G>A	c.(358-360)GAG>AAG	p.E120K	C16orf46_uc010chf.2_Missense_Mutation_p.E120K|C16orf46_uc010vno.1_5'UTR	NM_152337	NP_689550	Q6P387	CP046_HUMAN	chromosome 16 open reading frame 46 isoform 2	120											0						GGGCCCCCCTCAGTAGGAGGC	0.607													0	0	0	1	0	44	155										T	81095596	C	T	81095596	3	4	65	1	0	0	0	0	1	0	0	0	1815	835	29	1	861	1	C16orf46	16	81095596	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1462106	81095596	9259157	1104	20137										
PKD1L2	114780	broad.mit.edu	37	chr16	81198281	81198281	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggctcctggccgccctccaGagagctgagggaggaggcag	18	12	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:81198281G>A	uc002fgh.1	-	20	3313	c.3313C>T	c.(3313-3315)CTG>TTG	p.L1105L	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1105	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCGCCCTCCAGAGAGCTGAGG	0.488													0	0	0	1	0	27	89										A	81198281	G	A	81198281	2	1	65	1	0	0	0	0	0	0	0	1	11965	933	33	1		1	PKD1L2	16	81198281	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	102685	81198281	9156472	1105	20138										
MBTPS1	8720	broad.mit.edu	37	chr16	84129320	84129320	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgtagcatgccagaagccaGagcccagggagaggctggct	15	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:84129320G>C	uc002fhi.2	-	4	1014	c.512C>G	c.(511-513)TCT>TGT	p.S171C		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	171					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CCAGAAGCCAGAGCCCAGGGA	0.617													0	0	0	1	0	32	128										C	84129320	G	C	84129320	3	2	65	1	0	0	0	0	1	0	0	0	9361	942	33	1	2726	1	MBTPS1	16	84129320	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2931039	84129320	6225433	1106	20139										
TAF1C	9013	broad.mit.edu	37	chr16	84215615	84215615	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agctggatgcgtccaggtttCccaaggaattggggattgtc	14	8	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:84215615C>T	uc002fhn.2	-	8	999	c.771G>A	c.(769-771)GGG>GGA	p.G257G	TAF1C_uc002fhm.2_Silent_p.G190G|TAF1C_uc010vnx.1_Silent_p.G257G|TAF1C_uc010vny.1_5'UTR|TAF1C_uc010vnz.1_5'UTR|TAF1C_uc002fho.2_5'UTR|TAF1C_uc010voa.1_5'UTR|TAF1C_uc002fhp.1_RNA|TAF1C_uc010vob.1_Silent_p.G257G	NM_005679	NP_005670	Q15572	TAF1C_HUMAN	TBP-associated factor 1C isoform 1	257					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			ovary(1)	1						GTCCAGGTTTCCCAAGGAATT	0.547													0	0	0	1	0	39	119										T	84215615	C	T	84215615	2	4	65	1	0	0	0	0	0	0	0	1	15518	842	30	1		1	TAF1C	16	84215615	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	86295	84215615	6139138	1107	20140										
CRISPLD2	83716	broad.mit.edu	37	chr16	84883009	84883009	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggtatcgctctccggggttCcatgtgcagtcctggtatga	13	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:84883009C>T	uc010voh.1	+	4	605	c.378C>T	c.(376-378)TTC>TTT	p.F126F	CRISPLD2_uc010vog.1_Intron|CRISPLD2_uc002fio.2_Silent_p.F126F|CRISPLD2_uc002fim.2_Silent_p.F126F|CRISPLD2_uc002fin.3_Silent_p.F126F	NM_031476	NP_113664	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain	126						extracellular region|transport vesicle					0						CTCCGGGGTTCCATGTGCAGT	0.637													0	0	0	1	0	13	59										T	84883009	C	T	84883009	2	4	65	1	0	0	0	0	0	0	0	1	3883	854	30	1		1	CRISPLD2	16	84883009	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	667394	84883009	5471744	1108	20141										
ZC3H18	124245	broad.mit.edu	37	chr16	88694373	88694373	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taaagaggaaaagcggaaaaGggattcgtccacacaaccac	10	9	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:88694373G>C	uc002fky.2	+	15	2515	c.2315G>C	c.(2314-2316)AGG>ACG	p.R772T	ZC3H18_uc010voz.1_Missense_Mutation_p.R796T|ZC3H18_uc010chw.2_Intron|ZC3H18_uc002fkz.2_Missense_Mutation_p.R42T	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	772						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AAGCGGAAAAGGGATTCGTCC	0.547													0	0	0	1	0	35	96										C	88694373	G	C	88694373	3	2	65	1	0	0	0	0	1	0	0	0	17565	1000	35	4	2369	4	ZC3H18	16	88694373	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3811364	88694373	1660380	1109	20142										
TRAPPC2L	51693	broad.mit.edu	37	chr16	88926377	88926377	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccgggggaccgcatccagtCcaggtgggccctactttctg	13	15	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:88926377C>G	uc002fmc.2	+	4	424	c.371C>G	c.(370-372)TCC>TGC	p.S124C	TRAPPC2L_uc010cie.2_RNA|TRAPPC2L_uc002fmd.3_Missense_Mutation_p.S124C|TRAPPC2L_uc002fme.3_Missense_Mutation_p.S94C|TRAPPC2L_uc002fmf.2_Missense_Mutation_p.S93C|uc002fmg.2_5'Flank	NM_016209	NP_057293	Q9UL33	TPC2L_HUMAN	trafficking protein particle complex 2-like	124					ER to Golgi vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm					0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		CGCATCCAGTCCAGGTGGGCC	0.502													0	0	0	1	0	36	79										G	88926377	C	G	88926377	3	3	65	1	0	0	0	0	1	0	0	0	16456	855	30	1	385	1	TRAPPC2L	16	88926377	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	232004	88926377	1428376	1110	20143										
ANKRD11	29123	broad.mit.edu	37	chr16	89348573	89348573	+	Frame_Shift_Del	DEL	C	C	-													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgtgtttctctctcttcttCttctcttttaggatgttgat							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:89348573delC	uc002fmx.1	-	9	4838	c.4377delG	c.(4375-4377)AAGfs	p.K1459fs	ANKRD11_uc002fmy.1_Frame_Shift_Del_p.K1459fs|ANKRD11_uc002fnc.1_Frame_Shift_Del_p.K1459fs|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Frame_Shift_Del_p.K1416fs	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1459	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ctctcttcttcttctctttTA	0.343																		30	76	---	---								-	89348573	C	-	89348573	7	5	65	1	0	1	0	1	0	0	0	0	639	912	32	0	3634	0	ANKRD11	16	89348573	Frame_Shift_Del	DEL	C	TCGA-DK-A3WW-01A-22D-A23M-08	422196	89348573	1006180	1111	20144										
C16orf7	9605	broad.mit.edu	37	chr16	89777028	89777028	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atctcctccaccgcggtcttCagctgctgcagctggggctc	11	16	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:89777028C>T	uc002fom.1	-	10	1349	c.1224G>A	c.(1222-1224)CTG>CTA	p.L408L	C16orf7_uc002fol.1_Silent_p.L338L|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	408					ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCGCGGTCTTCAGCTGCTGCA	0.657													0	0	0	1	0	15	40										T	89777028	C	T	89777028	2	4	65	1	0	0	0	0	0	0	0	1	1828	813	29	1		1	C16orf7	16	89777028	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	428455	89777028	577725	1112	20145										
GAS8	2622	broad.mit.edu	37	chr16	90106743	90106743	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacgagctctatcggaagttCaccgcagccatccaggaggt	12	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr16:90106743C>T	uc002fqi.1	+	9	1169	c.1047C>T	c.(1045-1047)TTC>TTT	p.F349F	GAS8_uc010vps.1_Silent_p.F324F|GAS8_uc002fqh.2_Silent_p.F266F|GAS8_uc010vpv.1_Silent_p.F320F|GAS8_uc010cjc.1_Silent_p.F266F|GAS8_uc010vpw.1_Silent_p.F266F|GAS8_uc002fqj.1_Silent_p.F157F|LOC100130015_uc002fql.2_3'UTR|uc002fqm.1_5'Flank	NM_001481	NP_001472	O95995	GAS8_HUMAN	growth arrest-specific 8	349	Potential.				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		ATCGGAAGTTCACCGCAGCCA	0.622													0	0	0	1	0	4	15										T	90106743	C	T	90106743	2	4	65	1	0	0	0	0	0	0	0	1	6251	825	29	1		1	GAS8	16	90106743	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	329715	90106743	248010	1113	20146										
YWHAE	7531	broad.mit.edu	37	chr17	1257622	1257622	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagttctgcaattgcatcatCaaaagctgcttttgccaacc	6	12	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:1257622C>G	uc002fsj.2	-	5	750	c.598G>C	c.(598-600)GAT>CAT	p.D200H	YWHAE_uc002fsk.2_Missense_Mutation_p.D178H|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_RNA	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	200					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		ATTGCATCATCAAAAGCTGCT	0.353													0	0	0	1	0	13	29										G	1257622	C	G	1257622	3	3	65	1	0	0	0	0	1	0	0	0	17499	826	29	1	177	1	YWHAE	17	1257622	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		1257622	79937588	1114	20147										
SLC43A2	124935	broad.mit.edu	37	chr17	1478943	1478943	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagccgttgattttgaggaaGagtttgtcatcctcctgcct	11	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:1478943G>C	uc002fsv.2	-	14	1754	c.1665C>G	c.(1663-1665)CTC>CTG	p.L555L	SLC43A2_uc002fsu.2_Silent_p.L559L	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	555					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TTTTGAGGAAGAGTTTGTCAT	0.617													0	0	0	1	0	8	33										C	1478943	G	C	1478943	2	2	65	1	0	0	0	0	0	0	0	1	14633	929	33	1		1	SLC43A2	17	1478943	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	221321	1478943	79716267	1115	20148										
WDR81	124997	broad.mit.edu	37	chr17	1639411	1639411	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccccagtggccgtagtgtcGtggccggcttctcctcaggc	14	15	2	0	rs141513894	by1000genomes	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:1639411G>A	uc002fti.2	+	9	1984	c.1723G>A	c.(1723-1725)GTG>ATG	p.V575M	WDR81_uc002fth.2_Missense_Mutation_p.V751M|WDR81_uc010vqp.1_Missense_Mutation_p.V599M|WDR81_uc002ftj.2_Missense_Mutation_p.V1802M|WDR81_uc010vqq.1_Missense_Mutation_p.V433M	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	575										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCGTAGTGTCGTGGCCGGCTT	0.667													0	0	0	1	0	28	68										A	1639411	G	A	1639411	3	1	65	1	0	0	0	0	1	0	0	0	17327	1145	40	2	5500	2	WDR81	17	1639411	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	160468	1639411	79555799	1116	20149										
WDR81	124997	broad.mit.edu	37	chr17	1640893	1640893	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagctctgagaacttccgcGgcacgctcaccagcctggcc	10	17	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:1640893G>A	uc002fti.2	+	10	2320	c.2059G>A	c.(2059-2061)GGC>AGC	p.G687S	WDR81_uc002fth.2_Missense_Mutation_p.G863S|WDR81_uc010vqp.1_Missense_Mutation_p.G711S|WDR81_uc002ftj.2_Missense_Mutation_p.G1914S|WDR81_uc010vqq.1_Missense_Mutation_p.G545S	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	687										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GAACTTCCGCGGCACGCTCAC	0.632													0	0	0	1	0	23	64										A	1640893	G	A	1640893	3	1	65	1	0	0	0	0	1	0	0	0	17327	1116	39	2	5840	2	WDR81	17	1640893	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1482	1640893	79554317	1117	20150										
PAFAH1B1	5048	broad.mit.edu	37	chr17	2575996	2575996	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccatcatgcccaatggagatCatatagtgtctgcctcaagg	9	11	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:2575996C>T	uc002fuw.3	+	7	1184	c.616C>T	c.(616-618)CAT>TAT	p.H206Y	PAFAH1B1_uc010ckb.1_RNA|PAFAH1B1_uc010vqz.1_Missense_Mutation_p.H35Y	NM_000430	NP_000421	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase,	206	WD 3.|Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1						CAATGGAGATCATATAGTGTC	0.353													0	0	0	1	0	17	50										T	2575996	C	T	2575996	3	4	65	1	0	0	0	0	1	0	0	0	11384	826	29	1	638	1	PAFAH1B1	17	2575996	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	935103	2575996	78619214	1118	20151										
ZZEF1	23140	broad.mit.edu	37	chr17	3926119	3926119	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acggatctcctcaaaaccgtGagcctgccaagcagaagaag	10	12	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:3926119G>A	uc002fxe.2	-	44	7160	c.7096C>T	c.(7096-7098)CAC>TAC	p.H2366Y	ZZEF1_uc002fxh.2_Missense_Mutation_p.H680Y|ZZEF1_uc002fxi.2_Missense_Mutation_p.H601Y	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2366							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCAAAACCGTGAGCCTGCCAA	0.423													0	0	0	1	0	13	53										A	3926119	G	A	3926119	3	1	65	1	0	0	0	0	1	0	0	0	18252	1290	45	1	1837	1	ZZEF1	17	3926119	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1350123	3926119	77269091	1119	20152										
ZZEF1	23140	broad.mit.edu	37	chr17	3945848	3945848	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcttctgagatgacacttCtgaatcttcagcatctaagt	9	9	5	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:3945848C>G	uc002fxe.2	-	39	6245	c.6181G>C	c.(6181-6183)GAA>CAA	p.E2061Q	ZZEF1_uc002fxh.2_Missense_Mutation_p.E375Q|ZZEF1_uc002fxi.2_Missense_Mutation_p.E296Q|ZZEF1_uc002fxj.1_Missense_Mutation_p.E674Q	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2061							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GATGACACTTCTGAATCTTCA	0.448													0	0	0	1	0	22	63										G	3945848	C	G	3945848	3	3	65	1	0	0	0	0	1	0	0	0	18252	922	32	1	2772	1	ZZEF1	17	3945848	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	19729	3945848	77249362	1120	20153										
PELP1	27043	broad.mit.edu	37	chr17	4574817	4574817	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggccagcatggcagctgtgtCatcctgctccttttaggcac	11	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:4574817C>T	uc002fyi.3	-	17	3536	c.3310G>A	c.(3310-3312)GAC>AAC	p.D1104N	PELP1_uc010vsf.1_Missense_Mutation_p.D880N	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	1104					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						GCAGCTGTGTCATCCTGCTCC	0.512													0	0	0	1	0	7	33										T	4574817	C	T	4574817	3	4	65	1	0	0	0	0	1	0	0	0	11725	826	29	1	86	1	PELP1	17	4574817	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	628969	4574817	76620393	1121	20154										
INCA1	388324	broad.mit.edu	37	chr17	4891776	4891776	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggctgtgacagtgctgaacGaggccagagagtgcagctgc	16	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:4891776G>A	uc002gaj.2	-	8	1087	c.635C>T	c.(634-636)TCG>TTG	p.S212L	CAMTA2_uc010cku.1_5'Flank|CAMTA2_uc002gag.1_5'Flank|CAMTA2_uc002gah.1_5'Flank|CAMTA2_uc002gai.1_5'Flank|CAMTA2_uc010vsu.1_5'Flank|INCA1_uc002gak.2_Missense_Mutation_p.S212L|INCA1_uc002gal.2_Missense_Mutation_p.S197L|INCA1_uc002gam.2_Missense_Mutation_p.S197L	NM_213726	NP_998891	Q0VD86	INCA1_HUMAN	inhibitor of CDK, cyclin A1 interacting protein	212						nucleus					0						AGTGCTGAACGAGGCCAGAGA	0.567													0	0	0	1	0	26	74										A	4891776	G	A	4891776	3	1	65	1	0	0	0	0	1	0	0	0	7732	1059	37	1	79	1	INCA1	17	4891776	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	316959	4891776	76303434	1122	20155										
SLC13A5	284111	broad.mit.edu	37	chr17	6589554	6589554	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caatatgtgtcacattagccCagtcagggaaatgatccaag	9	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:6589554C>T	uc002gdj.2	-	12	1767	c.1679G>A	c.(1678-1680)TGG>TAG	p.W560*	SLC13A5_uc010vtf.1_Nonsense_Mutation_p.W514*|SLC13A5_uc010clq.2_Nonsense_Mutation_p.W517*|SLC13A5_uc002gdk.2_Nonsense_Mutation_p.W543*	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	560						integral to membrane	citrate transmembrane transporter activity				0						CACATTAGCCCAGTCAGGGAA	0.473													0	0	0	1	0	36	126										T	6589554	C	T	6589554	4	4	65	1	0	0	0	0	0	1	0	0	14395	595	21	2	31	2	SLC13A5	17	6589554	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1697778	6589554	74605656	1123	20156										
FBXO39	162517	broad.mit.edu	37	chr17	6683407	6683407	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttccagggtacatgcatctGaagttgagtcagctgtttgg	12	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:6683407G>A	uc010vtg.1	+	2	340	c.220G>A	c.(220-222)GAA>AAA	p.E74K		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	74										ovary(1)|skin(1)	2						ACATGCATCTGAAGTTGAGTC	0.463													0	0	0	1	0	34	112										A	6683407	G	A	6683407	3	1	65	1	0	0	0	0	1	0	0	0	5747	1291	45	1	222	1	FBXO39	17	6683407	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	93853	6683407	74511803	1124	20157										
KCTD11	147040	broad.mit.edu	37	chr17	7256927	7256927	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccgaccccgaagacctgctCaactccaggtctctgcgctt	8	18	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:7256927C>G	uc002gge.3	+	1	1720	c.666C>G	c.(664-666)CTC>CTG	p.L222L	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	222					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				AAGACCTGCTCAACTCCAGGT	0.602													0	0	0	1	0	19	44										G	7256927	C	G	7256927	2	3	65	1	0	0	0	0	0	0	0	1	8098	813	29	1		1	KCTD11	17	7256927	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	573520	7256927	73938283	1125	20158										
KCTD11	147040	broad.mit.edu	37	chr17	7256940	7256940	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acctgctcaactccaggtctCtgcgctttgtccggcactga	9	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:7256940C>G	uc002gge.3	+	1	1733	c.679C>G	c.(679-681)CTG>GTG	p.L227V	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	227					cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				CTCCAGGTCTCTGCGCTTTGT	0.592													0	0	0	1	0	18	42										G	7256940	C	G	7256940	3	3	65	1	0	0	0	0	1	0	0	0	8098	912	32	1	681	1	KCTD11	17	7256940	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	13	7256940	73938270	1126	20159										
TMEM95	339168	broad.mit.edu	37	chr17	7258907	7258907	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttgcccatctccacagatGaggtgtccatgaacaaagtc	8	13	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:7258907G>A	uc002ggh.1	+	2	199	c.172G>A	c.(172-174)GAG>AAG	p.E58K	TMEM95_uc002ggf.1_Missense_Mutation_p.E58K|TMEM95_uc002ggg.1_Missense_Mutation_p.E58K	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	58	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)				CTCCACAGATGAGGTGTCCAT	0.547													0	0	0	1	0	4	6										A	7258907	G	A	7258907	3	1	65	1	0	0	0	0	1	0	0	0	16220	1291	45	1	178	1	TMEM95	17	7258907	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1967	7258907	73936303	1127	20160										
DNAH2	146754	broad.mit.edu	37	chr17	7700820	7700820	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacctcacatttcatcatctCtgtcccagcaagcgtcctcc	5	17	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:7700820C>T	uc002giu.1	+	51	8066	c.8052C>T	c.(8050-8052)CTC>CTT	p.L2684L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2684					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TTCATCATCTCTGTCCCAGCA	0.532													0	0	0	1	0	47	183										T	7700820	C	T	7700820	2	4	65	1	0	0	0	0	0	0	0	1	4602	900	32	1		1	DNAH2	17	7700820	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	441913	7700820	73494390	1128	20161										
DNAH2	146754	broad.mit.edu	37	chr17	7733673	7733673	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgtcagaaccacagttttCccgctgctccaaacctgcca	7	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:7733673C>T	uc002giu.1	+	77	11923	c.11909C>T	c.(11908-11910)TCC>TTC	p.S3970F	DNAH2_uc010cnm.1_Missense_Mutation_p.S908F	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3970	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCACAGTTTTCCCGCTGCTCC	0.463													0	0	0	1	0	21	97										T	7733673	C	T	7733673	3	4	65	1	0	0	0	0	1	0	0	0	4602	855	30	1	12215	1	DNAH2	17	7733673	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	32853	7733673	73461537	1129	20162										
CYB5D1	124637	broad.mit.edu	37	chr17	7762898	7762898	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcacacacctgcaatacttCtgtacttcaatgatgatctc	4	12	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:7762898C>G	uc002gjb.3	+	4	1044	c.655C>G	c.(655-657)CTG>GTG	p.L219V	LSMD1_uc002giz.2_5'Flank|LSMD1_uc002gja.2_5'Flank|CYB5D1_uc010cnn.1_3'UTR	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	219							heme binding			skin(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				TGCAATACTTCTGTACTTCAA	0.448													0	0	0	1	0	30	80										G	7762898	C	G	7762898	3	3	65	1	0	0	0	0	1	0	0	0	4124	912	32	1	669	1	CYB5D1	17	7762898	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	29225	7762898	73432312	1130	20163										
ARHGEF15	22899	broad.mit.edu	37	chr17	8222686	8222686	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccaggcccccttccctgctCcccagacaccatctatgagg	7	20	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:8222686C>T	uc002glc.2	+	14	2364	c.2243C>T	c.(2242-2244)TCC>TTC	p.S748F	ARHGEF15_uc002gld.2_Missense_Mutation_p.S748F|ARHGEF15_uc010vuw.1_Missense_Mutation_p.S637F	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	748					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CTTCCCTGCTCCCCAGACACC	0.552													0	0	0	1	0	62	178										T	8222686	C	T	8222686	3	4	65	1	0	0	0	0	1	0	0	0	898	855	30	1	2293	1	ARHGEF15	17	8222686	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	459788	8222686	72972524	1131	20164										
PIK3R5	23533	broad.mit.edu	37	chr17	8814740	8814740	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggagcggcggctgaggctGagtccatgcaggcagcgttc	18	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:8814740G>A	uc002glt.2	-	2	139	c.72C>T	c.(70-72)CTC>CTT	p.L24L	PIK3R5_uc010vuz.1_Silent_p.L24L|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Silent_p.L24L|PIK3R5_uc010cob.1_Intron	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	24					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GGCTGAGGCTGAGTCCATGCA	0.672													0	0	0	1	0	20	67										A	8814740	G	A	8814740	2	1	65	1	0	0	0	0	0	0	0	1	11922	1277	45	1		1	PIK3R5	17	8814740	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	592054	8814740	72380470	1132	20165										
NTN1	9423	broad.mit.edu	37	chr17	8926117	8926117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtccctcggcaagaagttcGaagtgacctacgtgagcctg	12	11	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:8926117G>A	uc002glw.3	+	2	534	c.427G>A	c.(427-429)GAA>AAA	p.E143K		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	143	Laminin N-terminal.				apoptosis|axon guidance		protein binding				0						CAAGAAGTTCGAAGTGACCTA	0.607													0	0	0	1	0	7	30										A	8926117	G	A	8926117	3	1	65	1	0	0	0	0	1	0	0	0	10700	1059	37	1	429	1	NTN1	17	8926117	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	111377	8926117	72269093	1133	20166										
MAP2K4	6416	broad.mit.edu	37	chr17	12032537	12032537	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacaagtcgtgaaaggagatCctccgcagctgagtaattct	10	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:12032537C>A	uc002gnj.2	+	9	1042	c.973C>A	c.(973-975)CCT>ACT	p.P325T	MAP2K4_uc002gnk.2_Missense_Mutation_p.P336T|MAP2K4_uc010vvi.1_Missense_Mutation_p.P207T|MAP2K4_uc010vvj.1_Missense_Mutation_p.P197T	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	325	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		GAAAGGAGATCCTCCGCAGCT	0.433			D|Mis|N		pancreatic|breast|colorectal								1	0	4.7546e-09	1	4.94748e-09	14	34										A	12032537	C	A	12032537	3	1	65	1	0	0	0	0	1	0	0	0	9239	855	30	3	1007	3	MAP2K4	17	12032537	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3106420	12032537	69162673	1134	20167										
COX10	1352	broad.mit.edu	37	chr17	13980182	13980182	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atatgagatgagacctctctCaccgcccagcctatctttgt	7	13	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:13980182C>T	uc002gof.3	+	3	512	c.308C>T	c.(307-309)TCA>TTA	p.S103L	COX10_uc010vvs.1_Intron|COX10_uc010vvt.1_5'UTR	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	103					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		AGACCTCTCTCACCGCCCAGC	0.428													0	0	0	1	0	11	61										T	13980182	C	T	13980182	3	4	65	1	0	0	0	0	1	0	0	0	3762	838	29	1	318	1	COX10	17	13980182	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1947645	13980182	67215028	1135	20168										
CCDC144A	9720	broad.mit.edu	37	chr17	16612513	16612513	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccatactatcatccatactCtgggtcccaggaacatgttt	6	12	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:16612513C>T	uc002gqk.1	+	5	1218	c.1142C>T	c.(1141-1143)TCT>TTT	p.S381F	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	381											0						CATCCATACTCTGGGTCCCAG	0.373													0	0	0	1	0	16	58										T	16612513	C	T	16612513	3	4	65	1	0	0	0	0	1	0	0	0	2777	913	32	1	1160	1	CCDC144A	17	16612513	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2632331	16612513	64582697	1136	20169										
TOM1L2	146691	broad.mit.edu	37	chr17	17772713	17772713	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acatgcagcagctcctcggtGacctcctcattggacacgcg	10	15	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:17772713G>A	uc002grz.3	-	8	1009	c.852C>T	c.(850-852)GTC>GTT	p.V284V	TOM1L2_uc002gry.3_Silent_p.V234V|TOM1L2_uc010vwy.1_Silent_p.V231V|TOM1L2_uc010cpr.2_Silent_p.V239V|TOM1L2_uc010vwz.1_Silent_p.V136V|TOM1L2_uc010vxa.1_Silent_p.V186V|TOM1L2_uc010vxb.1_Silent_p.V234V|TOM1L2_uc002grv.3_Silent_p.V17V	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	284	GAT.				intracellular protein transport	intracellular					0	all_neural(463;0.228)					GCTCCTCGGTGACCTCCTCAT	0.527													0	0	0	1	0	20	70										A	17772713	G	A	17772713	2	1	65	1	0	0	0	0	0	0	0	1	16350	1277	45	1		1	TOM1L2	17	17772713	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1160200	17772713	63422497	1137	20170										
SHMT1	6470	broad.mit.edu	37	chr17	18232688	18232688	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgcagtccactgggccgcaGagcgcttctgtcacctacaa	10	16	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:18232688G>C	uc002gta.2	-	11	1376	c.1186C>G	c.(1186-1188)CTG>GTG	p.L396V	SHMT1_uc002gsz.2_Missense_Mutation_p.L171V|SHMT1_uc002gtb.2_Missense_Mutation_p.L357V|SHMT1_uc010cqb.2_Intron|SHMT1_uc010vxt.1_Missense_Mutation_p.L258V	NM_004169	NP_004160	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	396					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CTGGGCCGCAGAGCGCTTCTG	0.512													0	0	0	1	0	11	37										C	18232688	G	C	18232688	3	2	65	1	0	0	0	0	1	0	0	0	14285	933	33	1	273	1	SHMT1	17	18232688	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	459975	18232688	62962522	1138	20171										
VTN	7448	broad.mit.edu	37	chr17	26697287	26697287	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctccctgaagtctccgctctGatgcctgaggaagggaggga	14	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:26697287G>C	uc002hbc.2	-	1	87	c.-62C>G	c.(-64--60)ATCAG>ATGAG		SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor						cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	TCTCCGCTCTGATGCCTGAGG	0.597													0	0	0	1	0	16	36										C	26697287	G	C	26697287	1	2	65	1	0	0	0	0	0	0	0	0	17234	1305	45	1		1	VTN	17	26697287	Translation_Start_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8464599	26697287	54497923	1139	20172										
CRYBA1	1411	broad.mit.edu	37	chr17	27579109	27579109	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggttatgagcataccagcttCtgtgggcaacagtttatcct	10	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:27579109C>T	uc002hdw.2	+	4	250	c.243C>T	c.(241-243)TTC>TTT	p.F81F		NM_005208	NP_005199	P05813	CRBA1_HUMAN	crystallin, beta A3	81	Beta/gamma crystallin 'Greek key' 2.				visual perception	soluble fraction	structural constituent of eye lens				0			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			ATACCAGCTTCTGTGGGCAAC	0.502											OREG0024293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	28	95										T	27579109	C	T	27579109	2	4	65	1	0	0	0	0	0	0	0	1	3907	912	32	1		1	CRYBA1	17	27579109	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	881822	27579109	53616101	1140	20173										
EFCAB5	374786	broad.mit.edu	37	chr17	28380803	28380803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagaacaagggtcacgcagaGagtctattgcagaacaagat	11	8	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:28380803G>C	uc002het.2	+	10	2023	c.1831G>C	c.(1831-1833)GAG>CAG	p.E611Q	EFCAB5_uc010wbi.1_Missense_Mutation_p.E354Q|EFCAB5_uc010wbj.1_Missense_Mutation_p.E555Q|EFCAB5_uc010wbk.1_Missense_Mutation_p.E268Q|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.E490Q|EFCAB5_uc010csf.2_Missense_Mutation_p.E490Q	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	611							calcium ion binding			ovary(1)|skin(1)	2						GTCACGCAGAGAGTCTATTGC	0.478													0	0	0	1	0	54	140										C	28380803	G	C	28380803	3	2	65	1	0	0	0	0	1	0	0	0	4938	943	33	1	1869	1	EFCAB5	17	28380803	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	801694	28380803	52814407	1141	20174										
AP2B1	163	broad.mit.edu	37	chr17	33977735	33977735	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gttctttggcctctgtgtatCataagcctcccaatgctttt	7	11	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:33977735C>T	uc002hjr.2	+	13	1912	c.1723C>T	c.(1723-1725)CAT>TAT	p.H575Y	AP2B1_uc002hjq.2_Missense_Mutation_p.H575Y|AP2B1_uc010wci.1_Missense_Mutation_p.H537Y|AP2B1_uc002hjs.2_Missense_Mutation_p.H518Y|AP2B1_uc002hjt.2_Missense_Mutation_p.H575Y|AP2B1_uc010ctv.2_Missense_Mutation_p.H575Y|AP2B1_uc010wcj.1_Missense_Mutation_p.H312Y	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	575					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTCTGTGTATCATAAGCCTCC	0.463													0	0	0	1	0	46	106										T	33977735	C	T	33977735	3	4	65	1	0	0	0	0	1	0	0	0	741	826	29	1	1769	1	AP2B1	17	33977735	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5596932	33977735	47217475	1142	20175										
DDX52	11056	broad.mit.edu	37	chr17	36003428	36003428	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcccccgcgccgagccggcGaaagagatcgtggacgtcca	15	15	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36003428G>A	uc002hoi.1	-	1	60	c.22C>T	c.(22-24)CGC>TGC	p.R8C	DDX52_uc002hoh.1_5'UTR|DDX52_uc002hoj.1_5'Flank	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	8						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				CCGAGCCGGCGAAAGAGATCG	0.637													0	0	0	1	0	12	66										A	36003428	G	A	36003428	3	1	65	1	0	0	0	0	1	0	0	0	4370	1058	37	1	1837	1	DDX52	17	36003428	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2025693	36003428	45191782	1143	20176										
GPR179	440435	broad.mit.edu	37	chr17	36484647	36484647	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgctgatgtccattcctctCttgttctttcatttacctcc	5	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36484647C>G	uc002hpz.2	-	11	4826	c.4805G>C	c.(4804-4806)AGA>ACA	p.R1602T		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1602	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCATTCCTCTCTTGTTCTTTC	0.498													0	0	0	1	0	54	191										G	36484647	C	G	36484647	3	3	65	1	0	0	0	0	1	0	0	0	6674	913	32	1	2302	1	GPR179	17	36484647	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	481219	36484647	44710563	1144	20177			3	89		6	6	1716	C		2.306007e-08
GPR179	440435	broad.mit.edu	37	chr17	36485920	36485920	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtcatcctcctgcctctgtCttcttgttccctgctgccct	7	17	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36485920C>G	uc002hpz.2	-	11	3553	c.3532G>C	c.(3532-3534)GAC>CAC	p.D1178H		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1178	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CTGCCTCTGTCTTCTTGTTCC	0.552													0	0	0	1	0	73	248										G	36485920	C	G	36485920	3	3	65	1	0	0	0	0	1	0	0	0	6674	913	32	1	3575	1	GPR179	17	36485920	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1273	36485920	44709290	1145	20178			3	89		6	6	1716	C		2.306007e-08
GPR179	440435	broad.mit.edu	37	chr17	36486038	36486038	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ataagagcggcctgcttactCaccgccttgggccggcctag	12	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36486038C>T	uc002hpz.2	-	11	3435	c.3414G>A	c.(3412-3414)GTG>GTA	p.V1138V		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1138	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTGCTTACTCACCGCCTTGG	0.632													0	0	0	1	0	37	126										T	36486038	C	T	36486038	2	4	65	1	0	0	0	0	0	0	0	1	6674	813	29	1		1	GPR179	17	36486038	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	118	36486038	44709172	1146	20179			3	89		6	6	1716	C		2.306007e-08
GPR179	440435	broad.mit.edu	37	chr17	36486125	36486125	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgttctgcccctcgggactCtcctccacactctccttctc	5	20	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36486125C>T	uc002hpz.2	-	11	3348	c.3327G>A	c.(3325-3327)GAG>GAA	p.E1109E		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1109	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTCGGGACTCTCCTCCACAC	0.652													0	0	0	1	0	20	63										T	36486125	C	T	36486125	2	4	65	1	0	0	0	0	0	0	0	1	6674	912	32	1		1	GPR179	17	36486125	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	87	36486125	44709085	1147	20180			3	89		6	6	1716	C		2.306007e-08
GPR179	440435	broad.mit.edu	37	chr17	36486274	36486274	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcctgtcttcgtccacatCattagcttccctctggtgat	9	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36486274C>T	uc002hpz.2	-	11	3199	c.3178G>A	c.(3178-3180)GAT>AAT	p.D1060N		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1060	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCGTCCACATCATTAGCTTCC	0.572													0	0	0	1	0	34	70										T	36486274	C	T	36486274	3	4	65	1	0	0	0	0	1	0	0	0	6674	826	29	1	3929	1	GPR179	17	36486274	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	149	36486274	44708936	1148	20181			3	89		6	6	1716	C		2.306007e-08
GPR179	440435	broad.mit.edu	37	chr17	36486362	36486362	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actgcaacagagagggccctCcagagcctggctcgagctgg	14	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:36486362C>A	uc002hpz.2	-	11	3111	c.3090G>T	c.(3088-3090)TGG>TGT	p.W1030C		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1030	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGAGGGCCCTCCAGAGCCTGG	0.602													1	0	1.2476e-16	1	1.32012e-16	28	77										A	36486362	C	A	36486362	3	1	65	1	0	0	0	0	1	0	0	0	6674	856	30	3	4017	3	GPR179	17	36486362	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	88	36486362	44708848	1149	20182			3	89		6	6	1716	C		2.306007e-08
MED1	5469	broad.mit.edu	37	chr17	37564794	37564794	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatgagaaccaccagaacctGaactgataggggacttggct	11	9	0	4	rs144178898		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:37564794G>A	uc002hrv.3	-	17	3892	c.3680C>T	c.(3679-3681)TCA>TTA	p.S1227L	MED1_uc010wee.1_Missense_Mutation_p.S1055L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1227	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		ACCAGAACCTGAACTGATAGG	0.507										HNSCC(31;0.082)			0	0	0	1	0	20	68										A	37564794	G	A	37564794	3	1	65	1	0	0	0	0	1	0	0	0	9425	1294	45	1	1069	1	MED1	17	37564794	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1078432	37564794	43630416	1150	20183										
CDC6	990	broad.mit.edu	37	chr17	38449865	38449865	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attggaaaaacatatgactgCagagaagggccccatgatgt	11	7	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:38449865C>T	uc002huj.1	+	5	1028	c.818C>T	c.(817-819)GCA>GTA	p.A273V		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	273					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						CATATGACTGCAGAGAAGGGC	0.428													0	0	0	1	0	12	34										T	38449865	C	T	38449865	3	4	65	1	0	0	0	0	1	0	0	0	3083	710	25	2	832	2	CDC6	17	38449865	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	885071	38449865	42745345	1151	20184										
KRT24	192666	broad.mit.edu	37	chr17	38859916	38859916	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagctgctgcctccagccctGgaggaggaggcgcgagacga	17	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:38859916G>A	uc002hvd.2	-	1	87	c.30C>T	c.(28-30)TCC>TCT	p.S10S		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	10	Head.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				CTCCAGCCCTGGAGGAGGAGG	0.607													0	0	0	1	0	15	49										A	38859916	G	A	38859916	2	1	65	1	0	0	0	0	0	0	0	1	8461	1335	47	2		2	KRT24	17	38859916	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	410051	38859916	42335294	1152	20185										
ACLY	47	broad.mit.edu	37	chr17	40068700	40068700	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctgtcccagccgtggcttCagccaggacttgaccccatc	9	17	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40068700C>T	uc002hyg.2	-	3	418	c.255G>A	c.(253-255)CTG>CTA	p.L85L	ACLY_uc002hyh.2_Silent_p.L85L|ACLY_uc002hyi.2_Silent_p.L139L|ACLY_uc010wfx.1_Silent_p.L139L|ACLY_uc010wfy.1_Silent_p.L85L	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	85					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				GCCGTGGCTTCAGCCAGGACT	0.547													0	0	0	1	0	25	109										T	40068700	C	T	40068700	2	4	65	1	0	0	0	0	0	0	0	1	143	813	29	1		1	ACLY	17	40068700	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1208784	40068700	41126510	1153	20186										
NKIRAS2	28511	broad.mit.edu	37	chr17	40175730	40175730	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggagcagcggcgtgtagaccCagatgtggctcagcactggg	17	10	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40175730C>G	uc002hyq.2	+	4	460	c.395C>G	c.(394-396)CCA>CGA	p.P132R	NKIRAS2_uc010wgd.1_3'UTR|NKIRAS2_uc002hyr.2_Missense_Mutation_p.P132R|NKIRAS2_uc002hys.2_Missense_Mutation_p.P132R|NKIRAS2_uc010wge.1_Missense_Mutation_p.P76R|NKIRAS2_uc002hyt.2_Missense_Mutation_p.P132R	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	132	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CGTGTAGACCCAGATGTGGCT	0.587													0	0	0	1	0	14	87										G	40175730	C	G	40175730	3	3	65	1	0	0	0	0	1	0	0	0	10445	594	21	4	405	4	NKIRAS2	17	40175730	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	107030	40175730	41019480	1154	20187										
COASY	80347	broad.mit.edu	37	chr17	40716787	40716787	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgactggcatcagtggctctGggaagagctcaatagctcag	13	9	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40716787G>C	uc002hzz.2	+	5	1265	c.1108G>C	c.(1108-1110)GGG>CGG	p.G370R	COASY_uc010cyj.2_Missense_Mutation_p.G399R|COASY_uc002iab.2_Missense_Mutation_p.G75R|COASY_uc002iad.2_Missense_Mutation_p.G370R|COASY_uc002iac.2_Missense_Mutation_p.G370R|COASY_uc002iae.2_Missense_Mutation_p.G165R|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	370	DPCK.|ATP (Potential).				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CAGTGGCTCTGGGAAGAGCTC	0.587													0	0	0	1	0	56	153										C	40716787	G	C	40716787	3	2	65	1	0	0	0	0	1	0	0	0	3652	1348	47	4	1213	4	COASY	17	40716787	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	541057	40716787	40478423	1155	20188										
CCR10	2826	broad.mit.edu	37	chr17	40831665	40831665	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgcggcggggttgaggccctGaggggcagctcccaccccgt	17	15	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40831665G>A	uc002iax.3	-	2	999	c.995C>T	c.(994-996)TCA>TTA	p.S332L	PLEKHH3_uc002iau.2_5'Flank|PLEKHH3_uc002iav.2_5'Flank|PLEKHH3_uc010cym.1_5'Flank|PLEKHH3_uc002iaw.2_5'Flank|CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	332	Cytoplasmic (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		TTGAGGCCCTGAGGGGCAGCT	0.562													0	0	0	1	0	12	49										A	40831665	G	A	40831665	3	1	65	1	0	0	0	0	1	0	0	0	2940	1294	45	1	97	1	CCR10	17	40831665	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	114878	40831665	40363545	1156	20189			4	90	4345303	5	5	228	G		4.677787e-10
CCR10	2826	broad.mit.edu	37	chr17	40831709	40831709	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcctccgcaggtcctggcgGaagcgcaggcccaggaaggc	16	14	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40831709G>A	uc002iax.3	-	2	955	c.951C>T	c.(949-951)TTC>TTT	p.F317F	PLEKHH3_uc002iau.2_5'Flank|PLEKHH3_uc002iav.2_5'Flank|PLEKHH3_uc010cym.1_5'Flank|PLEKHH3_uc002iaw.2_5'Flank|CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	317	Cytoplasmic (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GGTCCTGGCGGAAGCGCAGGC	0.557													0	0	0	1	0	11	41										A	40831709	G	A	40831709	2	1	65	1	0	0	0	0	0	0	0	1	2940	1165	41	1		1	CCR10	17	40831709	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	44	40831709	40363501	1157	20190			4	90	4345303	5	5	228	G		4.677787e-10
CCR10	2826	broad.mit.edu	37	chr17	40831733	40831733	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgcaggcccaggaaggcgtaGagaacgggattgaggccaca	16	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40831733G>C	uc002iax.3	-	2	931	c.927C>G	c.(925-927)CTC>CTG	p.L309L	PLEKHH3_uc002iau.2_5'Flank|PLEKHH3_uc002iav.2_5'Flank|PLEKHH3_uc010cym.1_5'Flank|PLEKHH3_uc002iaw.2_5'Flank|CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	309	Helical; Name=7; (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GGAAGGCGTAGAGAACGGGAT	0.617													0	0	0	1	0	5	40										C	40831733	G	C	40831733	2	2	65	1	0	0	0	0	0	0	0	1	2940	929	33	1		1	CCR10	17	40831733	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	24	40831733	40363477	1158	20191			4	90	4345303	5	5	228	G		4.677787e-10
CCR10	2826	broad.mit.edu	37	chr17	40831760	40831760	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggattgaggccacagcgggcGagggccaagccgctggtcac	17	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40831760G>A	uc002iax.3	-	2	904	c.900C>T	c.(898-900)CTC>CTT	p.L300L	PLEKHH3_uc002iau.2_5'Flank|PLEKHH3_uc002iav.2_5'Flank|PLEKHH3_uc010cym.1_5'Flank|PLEKHH3_uc002iaw.2_5'Flank|CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	300	Helical; Name=7; (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		CACAGCGGGCGAGGGCCAAGC	0.682													0	0	0	1	0	6	35										A	40831760	G	A	40831760	2	1	65	1	0	0	0	0	0	0	0	1	2940	1045	37	1		1	CCR10	17	40831760	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	27	40831760	40363450	1159	20192			4	90	4345303	5	5	228	G		4.677787e-10
CCR10	2826	broad.mit.edu	37	chr17	40831892	40831892	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagggcagctgcagcaccacGaaggccgccaccagagccac	12	16	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40831892G>A	uc002iax.3	-	2	772	c.768C>T	c.(766-768)TTC>TTT	p.F256F	PLEKHH3_uc002iau.2_5'Flank|PLEKHH3_uc002iav.2_5'Flank|PLEKHH3_uc010cym.1_5'Flank|PLEKHH3_uc002iaw.2_5'Flank|CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	256	Helical; Name=6; (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GCAGCACCACGAAGGCCGCCA	0.711													0	0	0	1	0	5	18										A	40831892	G	A	40831892	2	1	65	1	0	0	0	0	0	0	0	1	2940	1049	37	1		1	CCR10	17	40831892	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	132	40831892	40363318	1160	20193			4	90	4345303	5	5	228	G		4.677787e-10
EZH1	2145	broad.mit.edu	37	chr17	40864325	40864325	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acctgcttgcacgtcttggtCcccagaagcctggctattga	10	13	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40864325C>A	uc002iaz.2	-	12	1528	c.1383G>T	c.(1381-1383)GGG>GGT	p.G461G	EZH1_uc002iba.2_Silent_p.G452G|EZH1_uc010wgt.1_Silent_p.G391G|EZH1_uc010wgu.1_Silent_p.G467G|EZH1_uc010wgv.1_Silent_p.G421G|EZH1_uc010wgw.1_Silent_p.G322G|EZH1_uc010cyp.2_Silent_p.G362G|EZH1_uc010cyq.2_Silent_p.G378G|EZH1_uc010cyo.1_Silent_p.G124G|EZH1_uc010cyr.1_Silent_p.G113G	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	461					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		ACGTCTTGGTCCCCAGAAGCC	0.532													1	0	1.96895e-08	1	2.0463e-08	24	94										A	40864325	C	A	40864325	2	1	65	1	0	0	0	0	0	0	0	1	5333	842	30	3		3	EZH1	17	40864325	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	32433	40864325	40330885	1161	20194										
WNK4	65266	broad.mit.edu	37	chr17	40947953	40947953	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catcccagcccagtgtggatGaactactcctacagcagcct	8	15	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:40947953G>A	uc002ibj.2	+	16	3354	c.3333G>A	c.(3331-3333)ATG>ATA	p.M1111I	WNK4_uc010wgx.1_Missense_Mutation_p.M775I|CCDC56_uc010wgz.1_Missense_Mutation_p.S102L|CNTD1_uc002ibm.3_5'Flank|CNTD1_uc010wha.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1111					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CAGTGTGGATGAACTACTCCT	0.587													0	0	0	1	0	24	61										A	40947953	G	A	40947953	3	1	65	1	0	0	0	0	1	0	0	0	17377	1290	45	1	3395	1	WNK4	17	40947953	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	83628	40947953	40247257	1162	20195										
RUNDC1	146923	broad.mit.edu	37	chr17	41143537	41143537	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgcatggcactgaatgagcAgcgtctggtgtcctgggtga	16	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:41143537A>G	uc002ici.1	+	5	1658	c.1646A>G	c.(1645-1647)CAG>CGG	p.Q549R	RUNDC1_uc010whi.1_Missense_Mutation_p.Q319R	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	549	RUN.										0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CTGAATGAGCAGCGTCTGGTG	0.547													0	0	0	1	0	17	57										G	41143537	A	G	41143537	3	3	65	1	0	0	0	0	1	0	0	0	13742	188	7	5	1664	5	RUNDC1	17	41143537	Missense_Mutation	SNP	A	TCGA-DK-A3WW-01A-22D-A23M-08	195584	41143537	40051673	1163	20196										
VAT1	10493	broad.mit.edu	37	chr17	41174209	41174209	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcagcgcagcagtggcggcGaggcggcggcggcggcggcc	23	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:41174209G>T	uc002icm.1	-	1	251	c.131C>A	c.(130-132)TCG>TAG	p.S44*	VAT1_uc010cyw.1_5'Flank|VAT1_uc010whk.1_Nonsense_Mutation_p.S44*	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	44						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		cagtggcggcgaggcggcggc	0.443													1	0	0.00909568	1	0.00916606	3	8										T	41174209	G	T	41174209	4	4	65	1	0	0	0	0	0	1	0	0	17126	1059	37	3	1074	3	VAT1	17	41174209	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	30672	41174209	40021001	1164	20197										
ETV4	2118	broad.mit.edu	37	chr17	41610076	41610076	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagtccgtctgttcctgtttGatcaccacccccgcccctgg	8	17	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:41610076G>A	uc002idw.2	-	8	905	c.777C>T	c.(775-777)ATC>ATT	p.I259I	ETV4_uc002idv.2_5'Flank|ETV4_uc010wih.1_Silent_p.I205I|ETV4_uc010czh.2_Silent_p.I258I|ETV4_uc010wii.1_Silent_p.I220I|ETV4_uc002idx.2_Silent_p.I259I|ETV4_uc010wij.1_Silent_p.I220I	NM_001986	NP_001977	P43268	ETV4_HUMAN	ets variant gene 4 (E1A enhancer binding	259					positive regulation of transcription, DNA-dependent	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/ETV4(6)	bone(4)|soft_tissue(2)|ovary(1)	7		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0798)		GTTCCTGTTTGATCACCACCC	0.587			T	EWSR1|TMPRSS2|DDX5|KLK2|CANT1	Ewing sarcoma|Prostate carcinoma								0	0	0	1	0	31	98										A	41610076	G	A	41610076	2	1	65	1	0	0	0	0	0	0	0	1	5281	1280	45	1		1	ETV4	17	41610076	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	435867	41610076	39585134	1165	20198										
UBTF	7343	broad.mit.edu	37	chr17	42289312	42289312	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccttggtgagggtggacttGgtgataccctcctcactgat	13	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:42289312G>C	uc002igb.2	-	8	901	c.834C>G	c.(832-834)ACC>ACG	p.T278T	UBTF_uc002igc.2_Silent_p.T241T|UBTF_uc010czs.2_Silent_p.T278T|UBTF_uc002igd.2_Silent_p.T241T|UBTF_uc010czt.2_Silent_p.T278T|UBTF_uc002ige.2_Silent_p.T241T	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	278					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GGGTGGACTTGGTGATACCCT	0.612													0	0	0	1	0	35	124										C	42289312	G	C	42289312	2	2	65	1	0	0	0	0	0	0	0	1	16906	1335	47	4		4	UBTF	17	42289312	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	679236	42289312	38905898	1166	20199										
SLC25A39	51629	broad.mit.edu	37	chr17	42398044	42398044	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccacagaagtctggtccttCggcctgaacccattgagcca	9	15	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:42398044C>T	uc002ign.2	-	9	901	c.747G>A	c.(745-747)CCG>CCA	p.P249P	SLC25A39_uc002igm.2_Silent_p.P241P|SLC25A39_uc002igo.2_Silent_p.P241P|SLC25A39_uc010wiw.1_Silent_p.P226P|SLC25A39_uc010czu.2_Silent_p.P117P|SLC25A39_uc010wix.1_3'UTR|SLC25A39_uc010wiy.1_3'UTR	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	249					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TCTGGTCCTTCGGCCTGAACC	0.597													0	0	0	1	0	51	121										T	42398044	C	T	42398044	2	4	65	1	0	0	0	0	0	0	0	1	14503	871	31	1		1	SLC25A39	17	42398044	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	108732	42398044	38797166	1167	20200										
HEXIM1	10614	broad.mit.edu	37	chr17	43227467	43227467	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctctcgcgcatggaggacGagaacaaccggctgcggctg	15	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:43227467G>A	uc002iig.2	+	1	2784	c.910G>A	c.(910-912)GAG>AAG	p.E304K		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	304	Mediates interaction with CCNT1.|Potential.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						CATGGAGGACGAGAACAACCG	0.647													0	0	0	1	0	16	163										A	43227467	G	A	43227467	3	1	65	1	0	0	0	0	1	0	0	0	7076	1059	37	1	912	1	HEXIM1	17	43227467	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	829423	43227467	37967743	1168	20201										
SKAP1	8631	broad.mit.edu	37	chr17	46262095	46262095	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcgtcctacctcatagctgCgcctatcctgggaggtcagt	11	13	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:46262095C>T	uc002ini.1	-	7	669	c.557G>A	c.(556-558)CGC>CAC	p.R186H	SKAP1_uc002inj.1_Missense_Mutation_p.R186H|SKAP1_uc010dbd.1_Missense_Mutation_p.R92H|SKAP1_uc010dbe.1_Missense_Mutation_p.R186H	NM_003726	NP_003717	Q86WV1	SKAP1_HUMAN	src kinase associated phosphoprotein 1 isoform	186	PH.				positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway	cytoplasm|nucleus|plasma membrane	antigen binding|protein kinase binding|SH2 domain binding				0						CTCATAGCTGCGCCTATCCTG	0.522													0	0	0	1	0	60	136										T	46262095	C	T	46262095	3	4	65	1	0	0	0	0	1	0	0	0	14355	768	27	2	546	2	SKAP1	17	46262095	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3034628	46262095	34933115	1169	20202										
HOXB8	3218	broad.mit.edu	37	chr17	46691686	46691686	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agctgtgtgggcgacgggctCtgctcggagccctcggcctc	16	14	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:46691686C>G	uc002inw.2	-	1	616	c.381G>C	c.(379-381)CAG>CAC	p.Q127H		NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	127						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCGACGGGCTCTGCTCGGAGC	0.706													0	0	0	1	0	7	27										G	46691686	C	G	46691686	3	3	65	1	0	0	0	0	1	0	0	0	7307	912	32	1	358	1	HOXB8	17	46691686	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	429591	46691686	34503524	1170	20203										
DLX4	1748	broad.mit.edu	37	chr17	48046847	48046847	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccacaatgacctctttgccCtgccccctccccggccggga	9	20	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:48046847C>T	uc002ipv.2	+	1	286	c.15C>T	c.(13-15)CCC>CCT	p.P5P		NM_138281	NP_612138	Q92988	DLX4_HUMAN	distal-less homeobox 4 isoform a	5				MTSLPCPLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAA SPNLSYSRPYGHLLSYPYTEPANPGDSYLSCQQPAALSQPL CGPAEHPQELEA -> GGSLSLPPEPLCARCPTKEGAAPRR PGFWGSLETQAATVWRGRHGHFSCRVRLSRGAARYSRRGQG KPGVTISAARLVFKVLSAGPLTHPAGRSRRLPRGHRLKPLS IALSLCLQCPSSVISRPRLSPGPSLSAPPYPKLAPPPVAEL RPPTAGAAVPWLWPSARFLPRVTGPIRVGAPLGAELRLVSP GAVNVGVETLHAE (in Ref. 9).	multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTCTTTGCCCTGCCCCCTCC	0.677													0	0	0	1	0	39	164										T	48046847	C	T	48046847	2	4	65	1	0	0	0	0	0	0	0	1	4573	668	24	2		2	DLX4	17	48046847	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1355161	48046847	33148363	1171	20204										
SAMD14	201191	broad.mit.edu	37	chr17	48194939	48194939	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgagggcggcggctcgtcctCgtccaggctgcgccgcaacc	15	17	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:48194939C>T	uc002iqg.2	-	4	630	c.331G>A	c.(331-333)GAG>AAG	p.E111K	SAMD14_uc002iqd.2_5'UTR|SAMD14_uc002iqe.2_5'UTR|SAMD14_uc002iqf.2_Missense_Mutation_p.E111K	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	111											0						GGCTCGTCCTCGTCCAGGCTG	0.761													0	0	0	1	0	3	9										T	48194939	C	T	48194939	3	4	65	1	0	0	0	0	1	0	0	0	13819	893	31	1	1038	1	SAMD14	17	48194939	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	148092	48194939	33000271	1172	20205										
MYCBPAP	84073	broad.mit.edu	37	chr17	48600299	48600299	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcttgtccctcctccttccaGaggcaggttgggattgctgc	11	13	1	1	rs56367701		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:48600299G>A	uc010wmr.1	+	11	1549	c.1387_splice	c.e11-1	p.R463_splice	MYCBPAP_uc002iqz.2_Splice_Site	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein						cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCTCCTTCCAGAGGCAGGTTG	0.373													0	0	0	1	0	23	72										A	48600299	G	A	48600299	5	1	65	1	0	0	0	0	0	0	1	0	10019	956	33	1	1428	1	MYCBPAP	17	48600299	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	405360	48600299	32594911	1173	20206										
SPATA20	64847	broad.mit.edu	37	chr17	48632592	48632592	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgacctttctattccggtcaGatcgtgatctgtggagaccg	11	10	3	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:48632592G>C	uc002irf.2	+	15	2251	c.2110_splice	c.e15-1	p.I704_splice	SPATA20_uc002irc.2_Splice_Site_p.I371_splice|SPATA20_uc002ire.2_Splice_Site_p.I660_splice|SPATA20_uc002ird.2_Splice_Site_p.I720_splice|SPATA20_uc002irg.2_Splice_Site	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20						cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			ATTCCGGTCAGATCGTGATCT	0.592													0	0	0	1	0	11	39										C	48632592	G	C	48632592	5	2	65	1	0	0	0	0	0	0	1	0	15005	956	33	1	2219	1	SPATA20	17	48632592	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	32293	48632592	32562618	1174	20207										
ABCC3	8714	broad.mit.edu	37	chr17	48741345	48741345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caactcagtcaaacgtgcgtCcactgtgggggaaattgtca	11	10	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:48741345C>T	uc002isl.2	+	10	1291	c.1211C>T	c.(1210-1212)TCC>TTC	p.S404F	ABCC3_uc002isk.3_Missense_Mutation_p.S404F|ABCC3_uc002ism.2_Silent_p.V116V	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	404	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AAACGTGCGTCCACTGTGGGG	0.577													0	0	0	1	0	54	68										T	48741345	C	T	48741345	3	4	65	1	0	0	0	0	1	0	0	0	54	855	30	1	1249	1	ABCC3	17	48741345	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	108753	48741345	32453865	1175	20208										
WFIKKN2	124857	broad.mit.edu	37	chr17	48917594	48917594	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggctgcagccacctcagaGagcagccccaatggcacggc	12	16	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:48917594G>C	uc002isv.3	+	2	1639	c.945G>C	c.(943-945)GAG>GAC	p.E315D	WFIKKN2_uc010dbu.2_Missense_Mutation_p.E222D	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	315						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CCACCTCAGAGAGCAGCCCCA	0.662													0	0	0	1	0	22	72										C	48917594	G	C	48917594	3	2	65	1	0	0	0	0	1	0	0	0	17356	933	33	1	951	1	WFIKKN2	17	48917594	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	176249	48917594	32277616	1176	20209										
MBTD1	54799	broad.mit.edu	37	chr17	49270356	49270356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctaatttcattcctacacGaaatccgtgatttggaacat	5	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:49270356G>A	uc002itr.3	-	15	1821	c.1477C>T	c.(1477-1479)CGT>TGT	p.R493C	MBTD1_uc002itp.3_Missense_Mutation_p.R329C|MBTD1_uc002itq.3_3'UTR	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	493	MBT 4.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			ATTCCTACACGAAATCCGTGA	0.363													0	0	0	1	0	33	86										A	49270356	G	A	49270356	3	1	65	1	0	0	0	0	1	0	0	0	9360	1058	37	1	421	1	MBTD1	17	49270356	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	352762	49270356	31924854	1177	20210										
CA10	56934	broad.mit.edu	37	chr17	50235295	50235295	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagccggccagggacagtcaCccccaagatcaatatcgcag	10	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:50235295C>T	uc002itw.3	-	1	838	c.-148G>A	c.(-150--146)GGGTG>GGATG		CA10_uc002itv.3_Translation_Start_Site|CA10_uc002itx.3_Translation_Start_Site|CA10_uc002ity.3_Translation_Start_Site|CA10_uc002itz.2_Translation_Start_Site	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X						brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GGGACAGTCACCCCCAAGATC	0.612													0	0	0	1	0	11	22										T	50235295	C	T	50235295	1	4	65	1	0	0	0	0	0	0	0	0	2511	522	18	2		2	CA10	17	50235295	Translation_Start_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	964939	50235295	30959915	1178	20211										
DGKE	8526	broad.mit.edu	37	chr17	54940071	54940071	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actcacaagacacatgcaatGatgttatatttctctggaga	7	8	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:54940071G>A	uc002iur.2	+	12	1803	c.1623G>A	c.(1621-1623)ATG>ATA	p.M541I	DGKE_uc002ius.1_3'UTR	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	541					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					CACATGCAATGATGTTATATT	0.453													0	0	0	1	0	18	10										A	54940071	G	A	54940071	3	1	65	1	0	0	0	0	1	0	0	0	4468	1290	45	1	1665	1	DGKE	17	54940071	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4704776	54940071	26255139	1179	20212										
MPO	4353	broad.mit.edu	37	chr17	56358002	56358002	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agagggctggggcgtggccaGaatggccaggagccctgcta	18	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:56358002G>C	uc002ivu.1	-	1	295	c.118C>G	c.(118-120)CTG>GTG	p.L40V		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	40					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	GGCGTGGCCAGAATGGCCAGG	0.582													0	0	0	1	0	23	80										C	56358002	G	C	56358002	3	2	65	1	0	0	0	0	1	0	0	0	9732	933	33	1	2167	1	MPO	17	56358002	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1417931	56358002	24837208	1180	20213										
HSF5	124535	broad.mit.edu	37	chr17	56540327	56540327	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actcaggtgactgtggtagaGagcaggcaactgcttgttct	13	8	2	2	rs145817491		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:56540327G>C	uc002iwi.1	-	4	1482	c.1358C>G	c.(1357-1359)TCT>TGT	p.S453C		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	453						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.S453F(1)		ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGTGGTAGAGAGCAGGCAAC	0.483													0	0	0	1	0	29	96										C	56540327	G	C	56540327	3	2	65	1	0	0	0	0	1	0	0	0	7399	942	33	1	444	1	HSF5	17	56540327	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	182325	56540327	24654883	1181	20214										
MTMR4	9110	broad.mit.edu	37	chr17	56569025	56569025	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaggtttctccccggcattCaactggaagctgtagcaatg	10	11	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:56569025C>T	uc002iwj.2	-	19	3697	c.3587G>A	c.(3586-3588)TGA>TAA	p.*1196*		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	1196						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCCGGCATTCAACTGGAAGC	0.468													0	0	0	1	0	19	57										T	56569025	C	T	56569025	2	4	65	1	0	0	0	0	0	0	0	1	9946	837	29	1		1	MTMR4	17	56569025	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	28698	56569025	24626185	1182	20215										
HEATR6	63897	broad.mit.edu	37	chr17	58128216	58128216	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacattaccggcagattgctGaaggcctctggcaagatgga	12	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:58128216G>A	uc002iyk.1	-	15	2429	c.2412C>T	c.(2410-2412)TTC>TTT	p.F804F	HEATR6_uc010ddk.1_Silent_p.F343F|HEATR6_uc010wos.1_Silent_p.F524F	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	804							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GCAGATTGCTGAAGGCCTCTG	0.502													0	0	0	1	0	15	51										A	58128216	G	A	58128216	2	1	65	1	0	0	0	0	0	0	0	1	7033	1281	45	1		1	HEATR6	17	58128216	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1559191	58128216	23066994	1183	20216										
CA4	762	broad.mit.edu	37	chr17	58234821	58234821	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggagaacaaggccagcatttCtggaggaggactgcctgccc	14	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:58234821C>T	uc002iym.3	+	4	396	c.302C>T	c.(301-303)TCT>TTT	p.S101F	CA4_uc010wou.1_Intron	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	101					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	GCCAGCATTTCTGGAGGAGGA	0.587													0	0	0	1	0	22	89										T	58234821	C	T	58234821	3	4	65	1	0	0	0	0	1	0	0	0	2518	913	32	1	316	1	CA4	17	58234821	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	106605	58234821	22960389	1184	20217										
BRIP1	83990	broad.mit.edu	37	chr17	59770842	59770842	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgatcatccactagaataaGagctccccaatcatttctgt	6	12	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:59770842G>C	uc002izk.1	-	18	2665	c.2524C>G	c.(2524-2526)CTT>GTT	p.L842V	BRIP1_uc002izl.1_Missense_Mutation_p.L223V	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	842					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						ACTAGAATAAGAGCTCCCCAA	0.353			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	1	0	17	44										C	59770842	G	C	59770842	3	2	65	1	0	0	0	0	1	0	0	0	1514	942	33	1	1237	1	BRIP1	17	59770842	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1536021	59770842	21424368	1185	20218										
MED13	9969	broad.mit.edu	37	chr17	60059866	60059866	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgttcagcagaggtagccctGagagcttcaaaacgtttttc	10	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:60059866G>C	uc002izo.2	-	16	3575	c.3498C>G	c.(3496-3498)CTC>CTG	p.L1166L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1166					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AGGTAGCCCTGAGAGCTTCAA	0.348													0	0	0	1	0	21	109										C	60059866	G	C	60059866	2	2	65	1	0	0	0	0	0	0	0	1	9430	1277	45	1		1	MED13	17	60059866	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	289024	60059866	21135344	1186	20219										
MED13	9969	broad.mit.edu	37	chr17	60140470	60140470	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcagcaaaactggggtcttCaccccaccaaaatatccaca	6	14	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:60140470C>T	uc002izo.2	-	2	336	c.259G>A	c.(259-261)GAA>AAA	p.E87K		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	87					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						CTGGGGTCTTCACCCCACCAA	0.418													0	0	0	1	0	28	69										T	60140470	C	T	60140470	3	4	65	1	0	0	0	0	1	0	0	0	9430	835	29	1	6381	1	MED13	17	60140470	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	80604	60140470	21054740	1187	20220										
TLK2	11011	broad.mit.edu	37	chr17	60685465	60685465	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atacgattcttaaagctactGaagtgcagttcccgccaaag	8	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:60685465G>A	uc010ddp.2	+	22	2369	c.2101G>A	c.(2101-2103)GAA>AAA	p.E701K	TLK2_uc002izx.3_Missense_Mutation_p.E527K|TLK2_uc002izz.3_Missense_Mutation_p.E679K|TLK2_uc002jaa.3_Missense_Mutation_p.E647K|TLK2_uc010wpd.1_Missense_Mutation_p.E647K	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	701	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TAAAGCTACTGAAGTGCAGTT	0.423													0	0	0	1	0	9	28										A	60685465	G	A	60685465	3	1	65	1	0	0	0	0	1	0	0	0	15941	1291	45	1	2113	1	TLK2	17	60685465	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	544995	60685465	20509745	1188	20221										
ACE	1636	broad.mit.edu	37	chr17	61560831	61560831	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccttttccagaaccaagtatCaggggatctgtcctcctgtt	8	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:61560831C>T	uc002jau.1	+	10	1520	c.1498C>T	c.(1498-1500)CAG>TAG	p.Q500*	ACE_uc010wpi.1_Silent_p.I451I|ACE_uc010ddu.1_Nonsense_Mutation_p.Q317*|ACE_uc002jav.1_5'Flank|ACE_uc010ddv.1_5'Flank|ACE_uc010wpj.1_5'Flank|ACE_uc002jaw.1_5'Flank|ACE_uc010wpk.1_5'Flank	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	500	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AACCAAGTATCAGGGGATCTG	0.448													0	0	0	1	0	23	76										T	61560831	C	T	61560831	4	4	65	1	0	0	0	0	0	1	0	0	136	827	29	1	1536	1	ACE	17	61560831	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	875366	61560831	19634379	1189	20222										
KCNH6	81033	broad.mit.edu	37	chr17	61601526	61601526	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agttcctgattgccaatgctCagatggagaactgcgccatc	10	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:61601526C>T	uc002jay.2	+	2	183	c.103C>T	c.(103-105)CAG>TAG	p.Q35*	KCNH6_uc002jax.1_Nonsense_Mutation_p.Q35*|KCNH6_uc010wpl.1_5'UTR|KCNH6_uc010wpm.1_Nonsense_Mutation_p.Q35*|KCNH6_uc002jaz.1_Nonsense_Mutation_p.Q35*	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	35	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	TGCCAATGCTCAGATGGAGAA	0.567													0	0	0	1	0	83	275										T	61601526	C	T	61601526	4	4	65	1	0	0	0	0	0	1	0	0	8036	827	29	1	109	1	KCNH6	17	61601526	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	40695	61601526	19593684	1190	20223										
FTSJ3	117246	broad.mit.edu	37	chr17	61901514	61901514	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagttgttcctcctcctcctCttcctcctcctccttagagg	5	18	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:61901514C>G	uc002jbz.2	-	11	1162	c.1084G>C	c.(1084-1086)GAG>CAG	p.E362Q	FTSJ3_uc002jca.2_Missense_Mutation_p.E362Q	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	362					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						tcctcctcctcttcctcctcc	0.458													0	0	0	1	0	51	177										G	61901514	C	G	61901514	3	3	65	1	0	0	0	0	1	0	0	0	6089	922	32	1	1499	1	FTSJ3	17	61901514	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	299988	61901514	19293696	1191	20224										
CCDC45	90799	broad.mit.edu	37	chr17	62533747	62533747	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cataaggtgaagagggagctGagatctaagatggagaagga	16	3	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:62533747G>A	uc002jem.2	+	20	2374	c.2316G>A	c.(2314-2316)CTG>CTA	p.L772L	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Silent_p.L608L	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	772	Potential.					centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGAGGGAGCTGAGATCTAAGA	0.453													0	0	0	1	0	12	26										A	62533747	G	A	62533747	2	1	65	1	0	0	0	0	0	0	0	1	2816	1277	45	1		1	CCDC45	17	62533747	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	632233	62533747	18661463	1192	20225										
RGS9	8787	broad.mit.edu	37	chr17	63156421	63156421	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgcaagaccccaagaatctCattctcaagcctgatggcag	8	13	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:63156421C>G	uc002jfe.2	+	4	386	c.276C>G	c.(274-276)CTC>CTG	p.L92L	RGS9_uc010dem.2_Silent_p.L92L|RGS9_uc002jfd.2_Silent_p.L92L|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	92	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCAAGAATCTCATTCTCAAGC	0.478													0	0	0	1	0	24	84										G	63156421	C	G	63156421	2	3	65	1	0	0	0	0	0	0	0	1	13313	813	29	1		1	RGS9	17	63156421	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	622674	63156421	18038789	1193	20226										
AXIN2	8313	broad.mit.edu	37	chr17	63545744	63545744	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacatagccagaacctatgtGataaggattaacaggatcgc	10	8	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:63545744G>A	uc002jfi.2	-	3	1139	c.850C>T	c.(850-852)CAC>TAC	p.H284Y	AXIN2_uc010den.1_Missense_Mutation_p.H284Y|AXIN2_uc002jfh.2_Missense_Mutation_p.H284Y	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	284					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						GAACCTATGTGATAAGGATTA	0.502									Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				0	0	0	1	0	6	23										A	63545744	G	A	63545744	3	1	65	1	0	0	0	0	1	0	0	0	1237	1290	45	1	1717	1	AXIN2	17	63545744	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	389323	63545744	17649466	1194	20227										
WIPI1	55062	broad.mit.edu	37	chr17	66423333	66423333	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tacggtcgctgcataagactGaggtaaggaaggtctgaggt	15	6	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:66423333G>A	uc010dey.2	-	11	1226	c.1135C>T	c.(1135-1137)CAG>TAG	p.Q379*	WIPI1_uc002jhd.3_RNA|WIPI1_uc010wqo.1_Nonsense_Mutation_p.Q297*|WIPI1_uc002jhe.3_RNA|MIR635_hsa-mir-635|MI0003650_5'Flank	NM_017983	NP_060453	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting	379					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0						GCATAAGACTGAGGTAAGGAA	0.502													0	0	0	1	0	21	86										A	66423333	G	A	66423333	4	1	65	1	0	0	0	0	0	1	0	0	17367	1299	45	1	217	1	WIPI1	17	66423333	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2877589	66423333	14771877	1195	20228										
PRKAR1A	5573	broad.mit.edu	37	chr17	66526076	66526076	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tataggggtcagctgctgtgCtacaacgtcggtcagaaaat	12	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:66526076C>G	uc002jhg.2	+	10	1087	c.907C>G	c.(907-909)CTA>GTA	p.L303V	PRKAR1A_uc002jhh.2_Missense_Mutation_p.L303V|PRKAR1A_uc002jhi.2_Missense_Mutation_p.L303V|PRKAR1A_uc002jhj.2_Missense_Mutation_p.L303V|PRKAR1A_uc002jhk.2_Missense_Mutation_p.L179V|PRKAR1A_uc002jhl.2_Missense_Mutation_p.L303V|PRKAR1A_uc002jhm.2_Missense_Mutation_p.L303V	NM_212471	NP_997636	P10644	KAP0_HUMAN	cAMP-dependent protein kinase, regulatory	303	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)					AGCTGCTGTGCTACAACGTCG	0.393			T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				0	0	0	1	0	34	103										G	66526076	C	G	66526076	3	3	65	1	0	0	0	0	1	0	0	0	12503	796	28	4	941	4	PRKAR1A	17	66526076	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	102743	66526076	14669134	1196	20229										
ABCA8	10351	broad.mit.edu	37	chr17	66890330	66890331	+	Nonsense_Mutation	DNP	CT	CT	TA													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttacctccaaaaatgtacttCtttcagttcggatatgtact							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:66890330_66890331CT>TA	uc002jhp.2	-	21	3078_3079	c.2899_2900AG>TA	c.(2899-2901)AGA>TAA	p.R967*	ABCA8_uc002jhq.2_Nonsense_Mutation_p.R1007*|ABCA8_uc010wqq.1_Nonsense_Mutation_p.R1007*|ABCA8_uc010wqr.1_Nonsense_Mutation_p.R946*|ABCA8_uc002jhr.2_Nonsense_Mutation_p.R1007*	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	967						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					AAATGTACTTCTTTCAGTTCGG	0.366													0	0	0	1	0	5	25										TA	66890331	CT	TA	66890330	4	4	65	1	0	0	0	0	0	1	0	0	38	913	32	1	1917	1	ABCA8	17	66890330	Nonsense_Mutation	DNP	CT	TCGA-DK-A3WW-01A-22D-A23M-08	364254	66890330	14304880	1197	20230										
ABCA8	10351	broad.mit.edu	37	chr17	66890366	66890366	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtactgatggtttaaccattCcaagtagcccattactaaca	6	10	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:66890366C>A	uc002jhp.2	-	21	3043	c.2864G>T	c.(2863-2865)GGA>GTA	p.G955V	ABCA8_uc002jhq.2_Missense_Mutation_p.G995V|ABCA8_uc010wqq.1_Missense_Mutation_p.G995V|ABCA8_uc010wqr.1_Missense_Mutation_p.G934V|ABCA8_uc002jhr.2_Missense_Mutation_p.G995V	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	955						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTTAACCATTCCAAGTAGCCC	0.343													1	0	3.59834e-05	1	3.66325e-05	6	24										A	66890366	C	A	66890366	3	1	65	1	0	0	0	0	1	0	0	0	38	855	30	3	1953	3	ABCA8	17	66890366	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	36	66890366	14304844	1198	20231										
ABCA10	10349	broad.mit.edu	37	chr17	67152011	67152011	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcagcttgaacatcttcatCttcttcttcgggctcttccg	6	13	7	1	rs140554607		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:67152011C>G	uc010dfa.1	-	30	4390	c.3511G>C	c.(3511-3513)GAT>CAT	p.D1171H	ABCA10_uc010wqs.1_Missense_Mutation_p.D163H|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1171					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					ACATCTTCATCTTCTTCTTCG	0.423													0	0	0	1	0	18	95										G	67152011	C	G	67152011	3	3	65	1	0	0	0	0	1	0	0	0	29	913	32	1	1164	1	ABCA10	17	67152011	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	261645	67152011	14043199	1199	20232										
CD300LD	100131439	broad.mit.edu	37	chr17	72584728	72584728	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaccaataactgtcagcatCatctcttttgagattctcca	4	12	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:72584728C>A	uc002jkz.2	-	2	330	c.301G>T	c.(301-303)GAT>TAT	p.D101Y	C17orf77_uc002jla.1_Intron	NM_001115152	NP_001108624	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d precursor	101	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity				0						CTGTCAGCATCATCTCTTTTG	0.443													1	0	9.31168e-06	1	9.53124e-06	14	155										A	72584728	C	A	72584728	3	1	65	1	0	0	0	0	1	0	0	0	3000	826	29	3	295	3	CD300LD	17	72584728	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5432717	72584728	8610482	1200	20233										
NUP85	79902	broad.mit.edu	37	chr17	73208116	73208116	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtgagtaaaaactaccgatCagtcatcagagcatgtatgg	10	7	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:73208116C>T	uc002jng.1	+	4	580	c.320C>T	c.(319-321)TCA>TTA	p.S107L	NUP85_uc010dgd.1_Missense_Mutation_p.S107L|NUP85_uc010wrv.1_Missense_Mutation_p.S61L	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	107					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			AACTACCGATCAGTCATCAGA	0.209													0	0	0	1	0	6	35										T	73208116	C	T	73208116	3	4	65	1	0	0	0	0	1	0	0	0	10770	838	29	1	334	1	NUP85	17	73208116	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	623388	73208116	7987094	1201	20234										
MRPS7	51081	broad.mit.edu	37	chr17	73258675	73258675	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagtggaggagctaactgagGaggagaaatatgttcgggag	17	4	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:73258675G>A	uc002jnm.3	+	2	414	c.181G>A	c.(181-183)GAG>AAG	p.E61K	GGA3_uc002jni.1_5'Flank|GGA3_uc002jnj.1_5'Flank|GGA3_uc010wrw.1_5'Flank|GGA3_uc002jnk.1_5'Flank|GGA3_uc010wrx.1_5'Flank|GGA3_uc010wry.1_5'Flank|GGA3_uc010wrz.1_5'Flank|MRPS7_uc002jnl.2_Missense_Mutation_p.E61K|MRPS7_uc002jnn.3_Missense_Mutation_p.E90K	NM_015971	NP_057055	Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7 precursor	61					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome	p.E61E(1)		central_nervous_system(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			GCTAACTGAGGAGGAGAAATA	0.473													0	0	0	1	0	45	188										A	73258675	G	A	73258675	3	1	65	1	0	0	0	0	1	0	0	0	9848	1175	41	1	187	1	MRPS7	17	73258675	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	50559	73258675	7936535	1202	20235										
ITGB4	3691	broad.mit.edu	37	chr17	73725400	73725400	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctccttcaagaacgtcatCagcctgacagaagatgtgga	9	10	4	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:73725400C>T	uc002jpg.2	+	7	808	c.621C>T	c.(619-621)ATC>ATT	p.I207I	ITGB4_uc002jph.2_Silent_p.I207I|ITGB4_uc010dgo.2_Silent_p.I207I|ITGB4_uc002jpi.3_Silent_p.I207I|ITGB4_uc010dgp.1_Silent_p.I207I|ITGB4_uc002jpj.2_Silent_p.I207I|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	207	VWFA.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGAACGTCATCAGCCTGACAG	0.597													0	0	0	1	0	19	79										T	73725400	C	T	73725400	2	4	65	1	0	0	0	0	0	0	0	1	7897	816	29	1		1	ITGB4	17	73725400	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	466725	73725400	7469810	1203	20236										
FBF1	85302	broad.mit.edu	37	chr17	73919562	73919562	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaactttcccgatgggcctCtctggtgggtgaggcaggga	16	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:73919562C>G	uc002jqc.2	-	13	1358	c.1084G>C	c.(1084-1086)GAG>CAG	p.E362Q	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E353Q|FBF1_uc002jqd.1_Missense_Mutation_p.E363Q|FBF1_uc010dgr.1_5'Flank	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	362											0						CGATGGGCCTCTCTGGTGGGT	0.652													0	0	0	1	0	4	14										G	73919562	C	G	73919562	3	3	65	1	0	0	0	0	1	0	0	0	5695	922	32	1	2385	1	FBF1	17	73919562	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	194162	73919562	7275648	1204	20237										
DNAH17	8632	broad.mit.edu	37	chr17	76422558	76422558	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctgatgcggagcagcaggtCtgcgtaccaggccgccaggc	15	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:76422558C>G	uc010dhp.1	-	24	4117	c.3895G>C	c.(3895-3897)GAC>CAC	p.D1299H	DNAH17_uc002jvq.2_Missense_Mutation_p.D584H|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGCAGCAGGTCTGCGTACCAG	0.627													0	0	0	1	0	14	31										G	76422558	C	G	76422558	3	3	65	1	0	0	0	0	1	0	0	0	4601	913	32	1	505	1	DNAH17	17	76422558	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2502996	76422558	4772652	1205	20238										
DNAH17	8632	broad.mit.edu	37	chr17	76557991	76557991	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgtcaaacagctccagcatGactgaatacctgggcgccac	10	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:76557991G>C	uc002jvv.1	-	8	853	c.747C>G	c.(745-747)GTC>GTG	p.V249V						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCTCCAGCATGACTGAATACC	0.577													0	0	0	1	0	7	31										C	76557991	G	C	76557991	2	2	65	1	0	0	0	0	0	0	0	1	4601	1277	45	1		1	DNAH17	17	76557991	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	135433	76557991	4637219	1206	20239										
USP36	57602	broad.mit.edu	37	chr17	76831483	76831483	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggagtcctgcgcccacgcgGaagacccgctcccacctcag	11	18	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:76831483G>A	uc002jvz.1	-	4	679	c.354C>T	c.(352-354)TTC>TTT	p.F118F	USP36_uc002jwa.1_Silent_p.F118F|USP36_uc002jwd.1_Silent_p.F118F	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	118					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CGCCCACGCGGAAGACCCGCT	0.592													0	0	0	1	0	9	41										A	76831483	G	A	76831483	2	1	65	1	0	0	0	0	0	0	0	1	17064	1165	41	1		1	USP36	17	76831483	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	273492	76831483	4363727	1207	20240										
CCDC40	55036	broad.mit.edu	37	chr17	78061848	78061848	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcaagatgcaggacaagctGaaccagctcagcgaggagaa	12	9	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:78061848G>A	uc010dht.2	+	16	2685	c.2658G>A	c.(2656-2658)CTG>CTA	p.L886L	CCDC40_uc002jxm.3_Silent_p.L669L|CCDC40_uc002jxn.3_Silent_p.L282L	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	886	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGACAAGCTGAACCAGCTCA	0.617													0	0	0	1	0	18	57										A	78061848	G	A	78061848	2	1	65	1	0	0	0	0	0	0	0	1	2812	1277	45	1		1	CCDC40	17	78061848	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1230365	78061848	3133362	1208	20241										
RNF213	57674	broad.mit.edu	37	chr17	78328356	78328356	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctgcaaccaggacgctctCcaggaggcgggcacattcag	13	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:78328356C>G	uc002jyh.1	+	11	5284	c.5061C>G	c.(5059-5061)CTC>CTG	p.L1687L	uc002jyi.1_RNA|RNF213_uc010dhw.1_Silent_p.L69L	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGGACGCTCTCCAGGAGGCGG	0.547													0	0	0	1	0	14	52										G	78328356	C	G	78328356	2	3	65	1	0	0	0	0	0	0	0	1	13477	842	30	1		1	RNF213	17	78328356	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	266508	78328356	2866854	1209	20242										
NOTUM	147111	broad.mit.edu	37	chr17	79918540	79918540	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggtcctcgttgagctgctgCgcggagcaggggtacaggga	18	9	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:79918540C>T	uc010wvg.1	-	1	518	c.246G>A	c.(244-246)GCG>GCA	p.A82A		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	82						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TGAGCTGCTGCGCGGAGCAGG	0.662													0	0	0	1	0	9	18										T	79918540	C	T	79918540	2	4	65	1	0	0	0	0	0	0	0	1	10552	755	27	2		2	NOTUM	17	79918540	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1590184	79918540	1276670	1210	20243										
ASPSCR1	79058	broad.mit.edu	37	chr17	79941448	79941448	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggtttcagaggagcgtgctCgacctttctctccagtggag	13	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:79941448C>T	uc002kcx.2	+	3	274	c.177C>T	c.(175-177)CTC>CTT	p.L59L	ASPSCR1_uc002kcw.1_Silent_p.L59L|ASPSCR1_uc002kcy.2_Silent_p.L59L|ASPSCR1_uc002kcz.2_Silent_p.L59L|ASPSCR1_uc002kda.2_5'UTR|ASPSCR1_uc002kdb.1_5'UTR	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	59							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GGAGCGTGCTCGACCTTTCTC	0.483			T	TFE3	alveolar soft part sarcoma								0	0	0	1	0	9	21										T	79941448	C	T	79941448	2	4	65	1	0	0	0	0	0	0	0	1	1059	871	31	1		1	ASPSCR1	17	79941448	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	22908	79941448	1253762	1211	20244										
LRRC45	201255	broad.mit.edu	37	chr17	79988621	79988621	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagagggcgagcttcctgcaGaacgccgtcctggcttacgt	13	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:79988621G>A	uc002kde.2	+	17	2193	c.1953G>A	c.(1951-1953)CAG>CAA	p.Q651Q	RAC3_uc002kdf.2_5'Flank	NM_144999	NP_659436	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	651						centrosome				pancreas(1)	1	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GCTTCCTGCAGAACGCCGTCC	0.697													0	0	0	1	0	12	15										A	79988621	G	A	79988621	2	1	65	1	0	0	0	0	0	0	0	1	9002	933	33	1		1	LRRC45	17	79988621	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	47173	79988621	1206589	1212	20245										
SLC16A3	9123	broad.mit.edu	37	chr17	80196577	80196577	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actgacggggtcttcccgcaGgcaaactcctggatgcgacc	12	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80196577G>A	uc002kea.2	+	5	1263	c.1124_splice	c.e5-1	p.G375_splice	SLC16A3_uc002kee.2_Intron|SLC16A3_uc002keb.2_Splice_Site_p.G375_splice|SLC16A3_uc002kec.2_Splice_Site_p.G375_splice|SLC16A3_uc002ked.2_Splice_Site_p.G375_splice	NM_001042422	NP_001035887	O15427	MOT4_HUMAN	solute carrier family 16, member 3						blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			upper_aerodigestive_tract(1)|lung(1)	2	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	TCTTCCCGCAGGCAAACTCCT	0.642													0	0	0	1	0	10	19										A	80196577	G	A	80196577	5	1	65	1	0	0	0	0	0	0	1	0	14409	1014	35	2	1137	2	SLC16A3	17	80196577	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	207956	80196577	998633	1213	20246										
FN3K	64122	broad.mit.edu	37	chr17	80708323	80708323	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggatctgttttgtggcctaGagattgtccccgcgttgctc	12	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80708323G>C	uc010wvs.1	+	6	683	c.622G>C	c.(622-624)GAG>CAG	p.E208Q	TBCD_uc002kfx.1_5'Flank|TBCD_uc002kfy.1_5'Flank|TBCD_uc002kfz.2_5'Flank	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	208					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			TTGTGGCCTAGAGATTGTCCC	0.582													0	0	0	1	0	34	102										C	80708323	G	C	80708323	3	2	65	1	0	0	0	0	1	0	0	0	5963	943	33	1	644	1	FN3K	17	80708323	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	511746	80708323	486887	1214	20247										
ZNF750	79755	broad.mit.edu	37	chr17	80788081	80788081	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgtcctgcagcttcgccttCttagctccttgctgggattt	10	12	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80788081C>G	uc002kga.2	-	3	2420	c.2109G>C	c.(2107-2109)AAG>AAC	p.K703N	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	703						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTTCGCCTTCTTAGCTCCTT	0.567													0	0	0	1	0	30	93										G	80788081	C	G	80788081	3	3	65	1	0	0	0	0	1	0	0	0	18129	912	32	1	66	1	ZNF750	17	80788081	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	79758	80788081	407129	1215	20248			5	91	39956189	6	6	2133	N	G_C	6.746576e-08
ZNF750	79755	broad.mit.edu	37	chr17	80788126	80788126	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcatcccttagacttgtcctCttttgtcctttgggtctgag	9	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80788126C>G	uc002kga.2	-	3	2375	c.2064G>C	c.(2062-2064)AAG>AAC	p.K688N	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	688						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GACTTGTCCTCTTTTGTCCTT	0.592													0	0	0	1	0	38	103										G	80788126	C	G	80788126	3	3	65	1	0	0	0	0	1	0	0	0	18129	912	32	1	111	1	ZNF750	17	80788126	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	45	80788126	407084	1216	20249			5	91	39956189	6	6	2133	N	G_C	6.746576e-08
ZNF750	79755	broad.mit.edu	37	chr17	80788419	80788419	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agggtggctgggcccatcctCagaaccttctgtcccagtct	11	14	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80788419C>G	uc002kga.2	-	3	2082	c.1771G>C	c.(1771-1773)GAG>CAG	p.E591Q	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	591						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GGCCCATCCTCAGAACCTTCT	0.677													0	0	0	1	0	24	89										G	80788419	C	G	80788419	3	3	65	1	0	0	0	0	1	0	0	0	18129	835	29	1	404	1	ZNF750	17	80788419	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	293	80788419	406791	1217	20250			5	91	39956189	6	6	2133	N	G_C	6.746576e-08
ZNF750	79755	broad.mit.edu	37	chr17	80789062	80789062	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggccttcgcaggtctggctCgtctgcatgaagtcggtggg	16	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80789062C>T	uc002kga.2	-	2	1580	c.1269G>A	c.(1267-1269)ACG>ACA	p.T423T	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	423						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGTCTGGCTCGTCTGCATGA	0.652													0	0	0	1	0	37	110										T	80789062	C	T	80789062	2	4	65	1	0	0	0	0	0	0	0	1	18129	871	31	1		1	ZNF750	17	80789062	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	643	80789062	406148	1218	20251			5	91	39956189	6	6	2133	N	G_C	6.746576e-08
ZNF750	79755	broad.mit.edu	37	chr17	80789532	80789532	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcaggggtgcgtcacactCaggcgagctcccagccagca	13	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80789532C>G	uc002kga.2	-	2	1110	c.799G>C	c.(799-801)GAG>CAG	p.E267Q	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	267						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCGTCACACTCAGGCGAGCTC	0.612													0	0	0	1	0	38	118										G	80789532	C	G	80789532	3	3	65	1	0	0	0	0	1	0	0	0	18129	835	29	1	1380	1	ZNF750	17	80789532	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	470	80789532	405678	1219	20252			5	91	39956189	6	6	2133	N	G_C	6.746576e-08
ZNF750	79755	broad.mit.edu	37	chr17	80790213	80790213	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atacttcatgtgattaaaaaGatgtgacttctcattgcaag	7	6	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr17:80790213G>C	uc002kga.2	-	2	429	c.118C>G	c.(118-120)CTT>GTT	p.L40V	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	40						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGATTAAAAAGATGTGACTTC	0.418													0	0	0	1	0	71	62										C	80790213	G	C	80790213	3	2	65	1	0	0	0	0	1	0	0	0	18129	942	33	1	2061	1	ZNF750	17	80790213	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	681	80790213	404997	1220	20253			5	91	39956189	6	6	2133	N	G_C	6.746576e-08
COLEC12	81035	broad.mit.edu	37	chr18	346722	346722	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttggcttgagagatagtggtGatgttctccatctgacctgt	12	7	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:346722G>A	uc002kkm.2	-	5	1115	c.900C>T	c.(898-900)ATC>ATT	p.I300I		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	300	Potential.|Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				AGATAGTGGTGATGTTCTCCA	0.502													0	0	0	1	0	19	65										A	346722	G	A	346722	2	1	65	1	0	0	0	0	0	0	0	1	3712	1280	45	1		1	COLEC12	18	346722	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		346722	77730526	1221	20254										
EMILIN2	84034	broad.mit.edu	37	chr18	2891158	2891158	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgacctgaaaaactcatgtGagtacaagctcactggcctc	8	12	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:2891158G>A	uc002kln.2	+	4	1192	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	345					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		AAACTCATGTGAGTACAAGCT	0.522													0	0	0	1	0	38	123										A	2891158	G	A	2891158	3	1	65	1	0	0	0	0	1	0	0	0	5094	1291	45	1	1047	1	EMILIN2	18	2891158	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2544436	2891158	75186090	1222	20255										
EPB41L3	23136	broad.mit.edu	37	chr18	5397426	5397426	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccgtcttggtttccattttCtgcatgggaagagattgtgg	12	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:5397426C>G	uc002kmt.1	-	18	2559	c.2473_splice	c.e18-1	p.K825_splice	EPB41L3_uc010wzh.1_Splice_Site_p.K656_splice|EPB41L3_uc002kmu.1_Splice_Site_p.K603_splice|EPB41L3_uc010dkq.1_Splice_Site_p.K494_splice|EPB41L3_uc002kms.1_Splice_Site_p.K60_splice|EPB41L3_uc010wze.1_Splice_Site_p.K130_splice|EPB41L3_uc010wzf.1_Splice_Site_p.K122_splice|EPB41L3_uc010wzg.1_Splice_Site_p.K97_splice|EPB41L3_uc010dkr.2_Splice_Site_p.K217_splice	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3						cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTTCCATTTTCTGCATGGGAA	0.517													0	0	0	1	0	24	87										G	5397426	C	G	5397426	5	3	65	1	0	0	0	0	0	0	1	0	5154	927	32	1	811	1	EPB41L3	18	5397426	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2506268	5397426	72679822	1223	20256										
LRRC30	339291	broad.mit.edu	37	chr18	7231348	7231348	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgactttctgtggggcttgtCcgaggtccagaaactcaatc	11	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:7231348C>A	uc010wzk.1	+	1	212	c.212C>A	c.(211-213)TCC>TAC	p.S71Y		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	71										ovary(1)|liver(1)	2						TGGGGCTTGTCCGAGGTCCAG	0.607													1	0	1.9806e-07	1	2.0496e-07	23	75										A	7231348	C	A	7231348	3	1	65	1	0	0	0	0	1	0	0	0	8985	855	30	3	214	3	LRRC30	18	7231348	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1833922	7231348	70845900	1224	20257										
TWSG1	57045	broad.mit.edu	37	chr18	9396492	9396492	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgaaccagccacaccaccaGaatgtgtctgtccccagcaa	8	15	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:9396492G>C	uc002knz.2	+	4	629	c.438G>C	c.(436-438)CAG>CAC	p.Q146H	TWSG1_uc002koa.2_Missense_Mutation_p.Q71H	NM_020648	NP_065699	Q9GZX9	TWSG1_HUMAN	twisted gastrulation precursor	146										ovary(1)|pancreas(1)	2						CACACCACCAGAATGTGTCTG	0.443													0	0	0	1	0	17	60										C	9396492	G	C	9396492	3	2	65	1	0	0	0	0	1	0	0	0	16782	933	33	1	448	1	TWSG1	18	9396492	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2165144	9396492	68680756	1225	20258										
CIDEA	1149	broad.mit.edu	37	chr18	12264384	12264384	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaccgtggtggacacagaaGagttctttcagaccttggga	13	9	2	3	rs139948292		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:12264384G>C	uc002kqt.3	+	3	327	c.262G>C	c.(262-264)GAG>CAG	p.E88Q	CIDEA_uc002kqu.3_Missense_Mutation_p.E122Q|CIDEA_uc010dlc.2_RNA	NM_001279	NP_001270	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a isoform	88	CIDE-N.				DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			ovary(1)|central_nervous_system(1)	2						GGACACAGAAGAGTTCTTTCA	0.512													0	0	0	1	0	19	58										C	12264384	G	C	12264384	3	2	65	1	0	0	0	0	1	0	0	0	3425	943	33	1	416	1	CIDEA	18	12264384	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2867892	12264384	65812864	1226	20259										
CEP192	55125	broad.mit.edu	37	chr18	13059091	13059091	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttttgaaggtggatctttCaacatatcgttgtttagttt	8	4	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:13059091C>G	uc010xac.1	+	21	4348	c.4268C>G	c.(4267-4269)TCA>TGA	p.S1423*	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Nonsense_Mutation_p.S948*|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Nonsense_Mutation_p.S1164*	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1423										ovary(4)|pancreas(1)	5						GTGGATCTTTCAACATATCGT	0.358													0	0	0	1	0	21	58										G	13059091	C	G	13059091	4	3	65	1	0	0	0	0	0	1	0	0	3251	838	29	1	4346	1	CEP192	18	13059091	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	794707	13059091	65018157	1227	20260										
MIB1	57534	broad.mit.edu	37	chr18	19427037	19427037	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cgccacttgatctctgtcctGatccgaatctctgcaaagca	7	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:19427037G>A	uc002ktq.2	+	16	2344	c.2344G>A	c.(2344-2346)GAT>AAT	p.D782N	MIB1_uc002ktp.2_Missense_Mutation_p.D421N	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	782					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			TCTCTGTCCTGATCCGAATCT	0.393													0	0	0	1	0	21	55										A	19427037	G	A	19427037	3	1	65	1	0	0	0	0	1	0	0	0	9566	1290	45	1	2406	1	MIB1	18	19427037	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6367946	19427037	58650211	1228	20261										
LAMA3	3909	broad.mit.edu	37	chr18	21327958	21327958	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgcaaattctcctcgccctGatctttgggtcttggaaaga	9	10	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:21327958G>A	uc002kuq.2	+	3	585	c.499G>A	c.(499-501)GAT>AAT	p.D167N	LAMA3_uc010dlv.1_Missense_Mutation_p.D167N|LAMA3_uc002kur.2_Missense_Mutation_p.D167N	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	167	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCTCGCCCTGATCTTTGGGT	0.348													0	0	0	1	0	21	68										A	21327958	G	A	21327958	3	1	65	1	0	0	0	0	1	0	0	0	8607	1290	45	1	509	1	LAMA3	18	21327958	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1900921	21327958	56749290	1229	20262										
DSC1	1823	broad.mit.edu	37	chr18	28720060	28720060	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctttgtatccaaggagttCttggccagctgggaagccat	12	9	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:28720060C>G	uc002kwn.2	-	10	1727	c.1465G>C	c.(1465-1467)GAA>CAA	p.E489Q	DSC1_uc002kwm.2_Missense_Mutation_p.E489Q	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	489	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CCAAGGAGTTCTTGGCCAGCT	0.428													0	0	0	1	0	22	74										G	28720060	C	G	28720060	3	3	65	1	0	0	0	0	1	0	0	0	4765	922	32	1	1287	1	DSC1	18	28720060	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	7392102	28720060	49357188	1230	20263										
DSG1	1828	broad.mit.edu	37	chr18	28916386	28916386	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaataaagctgaatttcatCattcaattatgtctcaatat	4	6	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:28916386C>A	uc002kwp.2	+	9	1287	c.1075C>A	c.(1075-1077)CAT>AAT	p.H359N		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	359	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TGAATTTCATCATTCAATTAT	0.343													1	0	0.184627	1	0.184846	5	25										A	28916386	C	A	28916386	3	1	65	1	0	0	0	0	1	0	0	0	4776	826	29	3	1109	3	DSG1	18	28916386	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	196326	28916386	49160862	1231	20264										
DSG1	1828	broad.mit.edu	37	chr18	28923426	28923426	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccaccagtggtcccatttttGatgatctgttgtgattgtgg	11	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:28923426G>C	uc002kwp.2	+	12	1913	c.1701G>C	c.(1699-1701)TTG>TTC	p.L567F	DSG1_uc010xbp.1_5'Flank	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	567	Helical; (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TCCCATTTTTGATGATCTGTT	0.423													0	0	0	1	0	32	122										C	28923426	G	C	28923426	3	2	65	1	0	0	0	0	1	0	0	0	4776	1281	45	1	1747	1	DSG1	18	28923426	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	7040	28923426	49153822	1232	20265										
DSG1	1828	broad.mit.edu	37	chr18	28923523	28923523	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caattcattcatgggcagtaGaaggaccacagcctgaaccc	9	12	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:28923523G>C	uc002kwp.2	+	12	2010	c.1798G>C	c.(1798-1800)GAA>CAA	p.E600Q	DSG1_uc010xbp.1_5'Flank	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	600	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			ATGGGCAGTAGAAGGACCACA	0.483													0	0	0	1	0	23	75										C	28923523	G	C	28923523	3	2	65	1	0	0	0	0	1	0	0	0	4776	943	33	1	1844	1	DSG1	18	28923523	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	97	28923523	49153725	1233	20266										
C18orf34	374864	broad.mit.edu	37	chr18	30913193	30913193	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagttcctgattctgcttaGagtccagtagagggccatgt	12	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:30913193G>C	uc002kxn.2	-	9	966	c.824C>G	c.(823-825)TCT>TGT	p.S275C	C18orf34_uc010xbr.1_Missense_Mutation_p.S275C|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.S275C|C18orf34_uc002kxp.2_Missense_Mutation_p.S275C	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	275	Potential.									ovary(1)	1						ATTCTGCTTAGAGTCCAGTAG	0.328													0	0	0	1	0	9	40										C	30913193	G	C	30913193	3	2	65	1	0	0	0	0	1	0	0	0	1902	942	33	1	1835	1	C18orf34	18	30913193	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1989670	30913193	47164055	1234	20267										
ASXL3	80816	broad.mit.edu	37	chr18	31319557	31319557	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttaacatcagaaacttcttCagtgtcttccatgcttctca	4	11	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:31319557C>T	uc010dmg.1	+	11	2244	c.2189C>T	c.(2188-2190)TCA>TTA	p.S730L	ASXL3_uc002kxq.2_Missense_Mutation_p.S437L	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	730	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GAAACTTCTTCAGTGTCTTCC	0.398													0	0	0	1	0	55	207										T	31319557	C	T	31319557	3	4	65	1	0	0	0	0	1	0	0	0	1068	838	29	1	2231	1	ASXL3	18	31319557	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	406364	31319557	46757691	1235	20268										
C18orf10	25941	broad.mit.edu	37	chr18	34376949	34376949	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatctagcttattcacaaagGagtcggtctcttctgtgagc	10	9	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:34376949G>C	uc002kzw.1	-	7	1150	c.722C>G	c.(721-723)TCC>TGC	p.S241C	C18orf10_uc002kzv.1_Intron|C18orf10_uc010xci.1_Missense_Mutation_p.S206C|C18orf10_uc002kzx.1_Missense_Mutation_p.S198C	NM_015476	NP_056291	Q68CL5	TPGS2_HUMAN	tubulin polyglutamylase complex subunit 2	241						cytoplasm|microtubule				skin(1)	1						ATTCACAAAGGAGTCGGTCTC	0.443													0	0	0	1	0	52	143										C	34376949	G	C	34376949	3	2	65	1	0	0	0	0	1	0	0	0	1895	1174	41	1	184	1	C18orf10	18	34376949	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3057392	34376949	43700299	1236	20269										
KIAA1328	57536	broad.mit.edu	37	chr18	34415224	34415224	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctgaaggaaatgtcagatCaagacacaagctgatgagtc	11	7	2	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:34415224C>G	uc002kzz.2	+	3	144	c.122C>G	c.(121-123)TCA>TGA	p.S41*		NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	41										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		AATGTCAGATCAAGACACAAG	0.393													0	0	0	1	0	17	56										G	34415224	C	G	34415224	4	3	65	1	0	0	0	0	0	1	0	0	8225	838	29	1	132	1	KIAA1328	18	34415224	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	38275	34415224	43662024	1237	20270										
SETBP1	26040	broad.mit.edu	37	chr18	42530198	42530198	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atccccaagcagccacagctCaccagccccacccagcagct	6	21	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:42530198C>T	uc010dni.2	+	4	1189	c.893C>T	c.(892-894)TCA>TTA	p.S298L		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	298						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AGCCACAGCTCACCAGCCCCA	0.567									Schinzel-Giedion_syndrome				0	0	0	1	0	22	88										T	42530198	C	T	42530198	3	4	65	1	0	0	0	0	1	0	0	0	14129	838	29	1	1096	1	SETBP1	18	42530198	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8114974	42530198	35547050	1238	20271										
SLC14A1	6563	broad.mit.edu	37	chr18	43319255	43319255	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctgcatgctgccataggatCattgctgggcatagcagcgg	13	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:43319255C>T	uc010xcn.1	+	8	1110	c.791C>T	c.(790-792)TCA>TTA	p.S264L	SLC14A1_uc010dnk.2_Missense_Mutation_p.S320L|SLC14A1_uc002lbf.3_Missense_Mutation_p.S264L|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.S159L|SLC14A1_uc002lbh.3_Missense_Mutation_p.S156L|SLC14A1_uc002lbi.3_Missense_Mutation_p.S132L|SLC14A1_uc002lbj.3_Missense_Mutation_p.S320L|SLC14A1_uc002lbk.3_Missense_Mutation_p.S264L	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	264						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						GCCATAGGATCATTGCTGGGC	0.537													0	0	0	1	0	27	81										T	43319255	C	T	43319255	3	4	65	1	0	0	0	0	1	0	0	0	14396	838	29	1	981	1	SLC14A1	18	43319255	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	789057	43319255	34757993	1239	20272										
TCEB3B	51224	broad.mit.edu	37	chr18	44561352	44561352	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctccccgaagcgctgtcggGaagcgctctcctcagggtcc	12	17	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:44561352G>T	uc002lcr.1	-	1	637	c.284C>A	c.(283-285)TCC>TAC	p.S95Y	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	95					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GCGCTGTCGGGAAGCGCTCTC	0.657													1	0	1.40151e-16	1	1.48112e-16	22	67										T	44561352	G	T	44561352	3	4	65	1	0	0	0	0	1	0	0	0	15679	1174	41	3	1981	3	TCEB3B	18	44561352	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1242097	44561352	33515896	1240	20273										
IER3IP1	51124	broad.mit.edu	37	chr18	44682582	44682582	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaagtaacacaattgcaattGagtttactattatcaatggc	6	6	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:44682582G>C	uc002lcu.2	-	3	312	c.215C>G	c.(214-216)TCA>TGA	p.S72*		NM_016097	NP_057181	Q9Y5U9	IR3IP_HUMAN	immediate early response 3 interacting protein	72	Helical; (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane					0						AATTGCAATTGAGTTTACTAT	0.303													0	0	0	1	0	7	30										C	44682582	G	C	44682582	4	2	65	1	0	0	0	0	0	1	0	0	7507	1294	45	1	37	1	IER3IP1	18	44682582	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	121230	44682582	33394666	1241	20274										
MYO5B	4645	broad.mit.edu	37	chr18	47581731	47581731	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catacctcatcagggtcaggGatccagacccttgtgcactg	10	13	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:47581731G>A	uc002leb.2	-	2	333	c.45C>T	c.(43-45)ATC>ATT	p.I15I	MYO5B_uc002lec.1_Silent_p.I14I	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	15	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CAGGGTCAGGGATCCAGACCC	0.453													0	0	0	1	0	23	84										A	47581731	G	A	47581731	2	1	65	1	0	0	0	0	0	0	0	1	10079	1164	41	1		1	MYO5B	18	47581731	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2899149	47581731	30495517	1242	20275										
CXXC1	30827	broad.mit.edu	37	chr18	47810410	47810410	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagcttcttgccgtgctcttCagcaatgcaagggctctgct	10	13	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:47810410C>T	uc002leq.3	-	10	2000	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc010xdi.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Missense_Mutation_p.E280K|CXXC1_uc002ler.3_Missense_Mutation_p.E427K|CXXC1_uc010doy.2_Missense_Mutation_p.E423K|CXXC1_uc002les.2_Missense_Mutation_p.E423K	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	423	Potential.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCGTGCTCTTCAGCAATGCAA	0.587													0	0	0	1	0	43	114										T	47810410	C	T	47810410	3	4	65	1	0	0	0	0	1	0	0	0	4097	835	29	1	727	1	CXXC1	18	47810410	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	228679	47810410	30266838	1243	20276										
ALPK2	115701	broad.mit.edu	37	chr18	56205258	56205258	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccatctctgtcttgtttttCttcatgctgtggaccacagg	9	11	4	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:56205258C>T	uc002lhj.3	-	5	2375	c.2161G>A	c.(2161-2163)GAA>AAA	p.E721K	ALPK2_uc002lhk.1_Missense_Mutation_p.E52K	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	721							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TCTTGTTTTTCTTCATGCTGT	0.448													0	0	0	1	0	48	138										T	56205258	C	T	56205258	3	4	65	1	0	0	0	0	1	0	0	0	545	922	32	1	4387	1	ALPK2	18	56205258	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8394848	56205258	21871990	1244	20277										
SERPINB5	5268	broad.mit.edu	37	chr18	61170752	61170752	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgatttctctggaatgtcaGagaccaagggagtggcccta	12	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:61170752G>C	uc002liz.3	+	7	1067	c.925G>C	c.(925-927)GAG>CAG	p.E309Q		NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade	309					cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1						TGGAATGTCAGAGACCAAGGG	0.438													0	0	0	1	0	29	53										C	61170752	G	C	61170752	3	2	65	1	0	0	0	0	1	0	0	0	14104	943	33	1	947	1	SERPINB5	18	61170752	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4965494	61170752	16906496	1245	20278										
SERPINB8	5271	broad.mit.edu	37	chr18	61654502	61654502	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttgttctgtggcaggttctCttctccgtaaagaggagcaa	11	9	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:61654502C>T	uc002ljv.2	+	7	1284	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F	SERPINB8_uc002lju.2_Missense_Mutation_p.S372F|SERPINB8_uc010xex.1_Missense_Mutation_p.S190F	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	372					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				GGCAGGTTCTCTTCTCCGTAA	0.473													0	0	0	1	0	19	54										T	61654502	C	T	61654502	3	4	65	1	0	0	0	0	1	0	0	0	14107	913	32	1	1150	1	SERPINB8	18	61654502	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	483750	61654502	16422746	1246	20279										
TSHZ1	10194	broad.mit.edu	37	chr18	72999280	72999280	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agagcaacgtgtctgccatgGaggagctggtggagaaggtc	17	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr18:72999280G>A	uc002lly.2	+	2	2346	c.1783G>A	c.(1783-1785)GAG>AAG	p.E595K		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	640						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		GTCTGCCATGGAGGAGCTGGT	0.637													0	0	0	1	0	17	83										A	72999280	G	A	72999280	3	1	65	1	0	0	0	0	1	0	0	0	16620	1175	41	1	1785	1	TSHZ1	18	72999280	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11344778	72999280	5077968	1247	20280										
CDC34	997	broad.mit.edu	37	chr19	541369	541369	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctggggaccaaggtggacgcGgagcgtgacggcgtgaaggt	20	8	0	2	rs143039634		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:541369G>A	uc002lov.2	+	5	727	c.528G>A	c.(526-528)GCG>GCA	p.A176A	GZMM_uc002low.1_5'Flank	NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	176					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGGACGCGGAGCGTGACG	0.716													0	0	0	1	0	5	18										A	541369	G	A	541369	2	1	65	1	0	0	0	0	0	0	0	1	3067	1103	39	2		2	CDC34	19	541369	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		541369	58587614	1248	20281										
FSTL3	10272	broad.mit.edu	37	chr19	677928	677928	+	Silent	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcacccacccggggaacaaGatcaacctcctcggcttctt							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:677928G>A	uc002lpk.1	+	2	275	c.240G>A	c.(238-240)AAG>AAA	p.K80K	FSTL3_uc010drt.1_5'Flank	NM_005860	NP_005851	O95633	FSTL3_HUMAN	follistatin-like 3 glycoprotein precursor	80	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGAACAAGATCAACCTCC	0.627			T	CCND1	B-CLL								0	0	0	1	0	29	109										A	677928	G	A	677928	2	1	65	1	0	0	0	0	0	0	0	1	6078	933	33	1		1	FSTL3	19	677928	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	136559	677928	58451055	1249	20282	100	2								
FSTL3	10272	broad.mit.edu	37	chr19	677931	677931	+	Silent	SNP	C	C	T													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acccacccggggaacaagatCaacctcctcggcttcttggg							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:677931C>T	uc002lpk.1	+	2	278	c.243C>T	c.(241-243)ATC>ATT	p.I81I	FSTL3_uc010drt.1_5'Flank	NM_005860	NP_005851	O95633	FSTL3_HUMAN	follistatin-like 3 glycoprotein precursor	81	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAACAAGATCAACCTCCTCG	0.622			T	CCND1	B-CLL								0	0	0	1	0	29	106										T	677931	C	T	677931	2	4	65	1	0	0	0	0	0	0	0	1	6078	816	29	1		1	FSTL3	19	677931	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3	677931	58451052	1250	20283	100	2								
REXO1	57455	broad.mit.edu	37	chr19	1828237	1828237	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgccctgacccctgtccaggGacgccagcgagtacttgctg	12	15	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:1828237G>A	uc002lua.3	-	2	646	c.551C>T	c.(550-552)TCC>TTC	p.S184F	REXO1_uc010dsr.1_Missense_Mutation_p.S138F	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	184						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGTCCAGGGACGCCAGCGA	0.716													0	0	0	1	0	7	32										A	1828237	G	A	1828237	3	1	65	1	0	0	0	0	1	0	0	0	13241	1174	41	1	3174	1	REXO1	19	1828237	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1150306	1828237	57300746	1251	20284										
ZNF77	58492	broad.mit.edu	37	chr19	2939284	2939284	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgacaccacccttacccaagGaggcaaggttcctgcaggtc	10	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:2939284G>C	uc002lws.3	-	2	256	c.125C>G	c.(124-126)TCC>TGC	p.S42C		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTACCCAAGGAGGCAAGGTT	0.567													0	0	0	1	0	18	61										C	2939284	G	C	2939284	3	2	65	1	0	0	0	0	1	0	0	0	18139	1174	41	1	1524	1	ZNF77	19	2939284	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1111047	2939284	56189699	1252	20285										
FZR1	51343	broad.mit.edu	37	chr19	3527044	3527044	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgtctccctactccctgtctCccgtcagcaacaagaggtgg	9	15	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:3527044C>A	uc010dtk.2	+	5	488	c.454C>A	c.(454-456)CCC>ACC	p.P152T	FZR1_uc002lxt.2_Missense_Mutation_p.P152T|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	152					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCCTGTCTCCCGTCAGCAA	0.642													1	0	6.05902e-23	1	6.45152e-23	32	112										A	3527044	C	A	3527044	3	1	65	1	0	0	0	0	1	0	0	0	6138	855	30	3	472	3	FZR1	19	3527044	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	587760	3527044	55601939	1253	20286										
C19orf28	126321	broad.mit.edu	37	chr19	3550998	3550998	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccacctgagtgccgtgagctCcaccttctcatggtcgttgg	11	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:3550998C>G	uc002lxz.2	-	2	663	c.493G>C	c.(493-495)GAG>CAG	p.E165Q	C19orf28_uc002lxw.2_Missense_Mutation_p.E165Q|C19orf28_uc002lxx.2_Missense_Mutation_p.E165Q|C19orf28_uc002lxy.2_Missense_Mutation_p.E156Q	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	165					transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGTGAGCTCCACCTTCTCA	0.592													0	0	0	1	0	17	28										G	3550998	C	G	3550998	3	3	65	1	0	0	0	0	1	0	0	0	1917	864	30	1	1192	1	C19orf28	19	3550998	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	23954	3550998	55577985	1254	20287										
GIPC3	126326	broad.mit.edu	37	chr19	3590172	3590172	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggccgccatcggcgaggccaGagaggcctgtggctagtttg	17	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:3590172G>C	uc002lyd.3	+	6	950	c.923G>C	c.(922-924)AGA>ACA	p.R308T		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	308										breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGAGGCCAGAGAGGCCTGT	0.433													0	0	0	1	0	4	10										C	3590172	G	C	3590172	3	2	65	1	0	0	0	0	1	0	0	0	6394	942	33	1	945	1	GIPC3	19	3590172	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	39174	3590172	55538811	1255	20288										
MATK	4145	broad.mit.edu	37	chr19	3779175	3779175	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctccaggtactccatgccctCggccacgtgcctgggggtag	13	15	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:3779175C>G	uc002lyt.2	-	12	1412	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q	MATK_uc002lyv.2_Missense_Mutation_p.E339Q|MATK_uc002lyu.2_Missense_Mutation_p.E297Q|MATK_uc010dtq.2_Missense_Mutation_p.E338Q	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	338	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCATGCCCTCGGCCACGTGC	0.652													0	0	0	1	0	4	20										G	3779175	C	G	3779175	3	3	65	1	0	0	0	0	1	0	0	0	9332	893	31	1	523	1	MATK	19	3779175	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	189003	3779175	55349808	1256	20289										
PTPRS	5802	broad.mit.edu	37	chr19	5231463	5231463	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggtcggggggatgccgttCacctccttgggttccgggtc	17	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:5231463C>T	uc002mbv.2	-	14	2247	c.2013G>A	c.(2011-2013)GTG>GTA	p.V671V	PTPRS_uc002mbu.1_Intron|PTPRS_uc010xin.1_Intron|PTPRS_uc002mbw.2_Silent_p.V658V|PTPRS_uc002mbx.2_Intron|PTPRS_uc002mby.2_Intron	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	671	Extracellular (Potential).|Fibronectin type-III 4.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGATGCCGTTCACCTCCTTGG	0.672													0	0	0	1	0	20	46										T	5231463	C	T	5231463	2	4	65	1	0	0	0	0	0	0	0	1	12811	813	29	1		1	PTPRS	19	5231463	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1452288	5231463	53897520	1257	20290										
LONP1	9361	broad.mit.edu	37	chr19	5711936	5711936	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctccttcttgccccgctttGacttcctgcggggcttgtgc	10	16	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:5711936G>A	uc002mcx.2	-	4	749	c.716C>T	c.(715-717)TCA>TTA	p.S239L	LONP1_uc002mcy.2_Missense_Mutation_p.S175L|LONP1_uc010duh.2_5'UTR|LONP1_uc010dui.2_Missense_Mutation_p.S239L|LONP1_uc002mcz.2_Missense_Mutation_p.S43L	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	239	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GCCCCGCTTTGACTTCCTGCG	0.667													0	0	0	1	0	27	65										A	5711936	G	A	5711936	3	1	65	1	0	0	0	0	1	0	0	0	8892	1294	45	1	2223	1	LONP1	19	5711936	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	480473	5711936	53417047	1258	20291										
SLC25A41	284427	broad.mit.edu	37	chr19	6426469	6426469	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccacctgctggtaagaccttCagtagcgtgggggtcatgcc	13	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:6426469C>T	uc010dus.2	-	7	1130	c.1044G>A	c.(1042-1044)CTG>CTA	p.L348L	KHSRP_uc002mer.3_5'Flank|SLC25A41_uc010dut.2_Silent_p.L210L	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	348	Helical; Name=6; (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						GTAAGACCTTCAGTAGCGTGG	0.602													0	0	0	1	0	25	78										T	6426469	C	T	6426469	2	4	65	1	0	0	0	0	0	0	0	1	14506	813	29	1		1	SLC25A41	19	6426469	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	714533	6426469	52702514	1259	20292										
DENND1C	79958	broad.mit.edu	37	chr19	6467705	6467705	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctccagagaactggggtctGaggaaggatcaaggggctgg	17	8	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:6467705G>C	uc002mfe.2	-	23	2308	c.2216C>G	c.(2215-2217)TCA>TGA	p.S739*	DENND1C_uc002mfb.2_Nonsense_Mutation_p.S289*|DENND1C_uc002mfc.2_Nonsense_Mutation_p.S289*|DENND1C_uc002mfd.2_Nonsense_Mutation_p.S289*|DENND1C_uc010xje.1_Nonsense_Mutation_p.S695*	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	739						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						ACTGGGGTCTGAGGAAGGATC	0.632													0	0	0	1	0	8	29										C	6467705	G	C	6467705	4	2	65	1	0	0	0	0	0	1	0	0	4428	1294	45	1	193	1	DENND1C	19	6467705	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	41236	6467705	52661278	1260	20293										
C3	718	broad.mit.edu	37	chr19	6692953	6692953	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acaatcatttcttggtgtatCacgggcgcatcctcctggaa	9	11	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:6692953C>T	uc002mfm.2	-	26	3434	c.3372G>A	c.(3370-3372)GTG>GTA	p.V1124V	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1124					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTTGGTGTATCACGGGCGCAT	0.562													0	0	0	1	0	48	185										T	6692953	C	T	6692953	2	4	65	1	0	0	0	0	0	0	0	1	2204	813	29	1		1	C3	19	6692953	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	225248	6692953	52436030	1261	20294										
NDUFA7	4701	broad.mit.edu	37	chr19	8381530	8381530	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttgggaggaggctgagttCtgaggggaaaaaagatgagc	18	4	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:8381530C>A	uc002mjm.1	-	3	140	c.102_splice	c.e3-1	p.R34_splice		NM_005001	NP_004992	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	AGGCTGAGTTCTGAGGGGAAA	0.562													1	0	7.33532e-06	1	7.51282e-06	24	92										A	8381530	C	A	8381530	5	1	65	1	0	0	0	0	0	0	1	0	10270	927	32	3	248	3	NDUFA7	19	8381530	Splice_Site	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1688577	8381530	50747453	1262	20295										
RPS28	6234	broad.mit.edu	37	chr19	8386542	8386542	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagcttctttcctccaggtCaccaaggtcctgggcaggac	10	15	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:8386542C>T	uc002mjn.2	+	2	73	c.42C>T	c.(40-42)GTC>GTT	p.V14V	NDUFA7_uc002mjm.1_5'Flank	NM_001031	NP_001022	P62857	RS28_HUMAN	ribosomal protein S28	14					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome				0						TCCTCCAGGTCACCAAGGTCC	0.637													0	0	0	1	0	6	18										T	8386542	C	T	8386542	2	4	65	1	0	0	0	0	0	0	0	1	13641	813	29	1		1	RPS28	19	8386542	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	5012	8386542	50742441	1263	20296										
MUC16	94025	broad.mit.edu	37	chr19	9059942	9059942	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcacaggaagcgaagaagaGtggatgctgtctggtaatgt	15	5	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9059942G>A	uc002mkp.2	-	3	27708	c.27504C>T	c.(27502-27504)CAC>CAT	p.H9168H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9170	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCGAAGAAGAGTGGATGCTGT	0.517													0	0	0	1	0	10	54										A	9059942	G	A	9059942	2	1	65	1	0	0	0	0	0	0	0	1	9973	1020	36	2		2	MUC16	19	9059942	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	673400	9059942	50069041	1264	20297										
MUC16	94025	broad.mit.edu	37	chr19	9071650	9071650	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgggtggtgatcgtcatttCtgcagattttgtcttaatag	11	5	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9071650C>T	uc002mkp.2	-	3	16000	c.15796G>A	c.(15796-15798)GAA>AAA	p.E5266K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5268	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATCGTCATTTCTGCAGATTTT	0.512													0	0	0	1	0	11	93										T	9071650	C	T	9071650	3	4	65	1	0	0	0	0	1	0	0	0	9973	922	32	1	28055	1	MUC16	19	9071650	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	11708	9071650	50057333	1265	20298										
MUC16	94025	broad.mit.edu	37	chr19	9083542	9083542	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aactctgactgaatacaaggGaaccagtagttcccgcaggc	10	11	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9083542G>A	uc002mkp.2	-	1	8477	c.8273C>T	c.(8272-8274)TCC>TTC	p.S2758F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2758	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAATACAAGGGAACCAGTAGT	0.488													0	0	0	1	0	19	57										A	9083542	G	A	9083542	3	1	65	1	0	0	0	0	1	0	0	0	9973	1174	41	1	35586	1	MUC16	19	9083542	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	11892	9083542	50045441	1266	20299										
OR1M1	125963	broad.mit.edu	37	chr19	9204520	9204520	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgaataggatcttcatcctCattgtggcagggatggtgat	13	6	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9204520C>G	uc010xkj.1	+	1	600	c.600C>G	c.(598-600)CTC>CTG	p.L200L		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						TCTTCATCCTCATTGTGGCAG	0.567													0	0	0	1	0	31	138										G	9204520	C	G	9204520	2	3	65	1	0	0	0	0	0	0	0	1	10968	813	29	1		1	OR1M1	19	9204520	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	120978	9204520	49924463	1267	20300										
OR7D2	162998	broad.mit.edu	37	chr19	9297281	9297281	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccagaaaatctccgtggcctCggtgatgtacactgtggtca	11	11	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9297281C>T	uc002mkz.1	+	1	1012	c.824C>T	c.(823-825)TCG>TTG	p.S275L		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	275	Helical; Name=7; (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						TCCGTGGCCTCGGTGATGTAC	0.547													0	0	0	1	0	32	99										T	9297281	C	T	9297281	3	4	65	1	0	0	0	0	1	0	0	0	11219	893	31	1	826	1	OR7D2	19	9297281	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	92761	9297281	49831702	1268	20301										
OR7E24	26648	broad.mit.edu	37	chr19	9362193	9362193	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atcatcatgaacccacgcctCtgtggcttcttaatcttgtt	6	12	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9362193C>T	uc002mlb.1	+	1	474	c.474C>T	c.(472-474)CTC>CTT	p.L158L		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACCCACGCCTCTGTGGCTTCT	0.458													0	0	0	1	0	10	44										T	9362193	C	T	9362193	2	4	65	1	0	0	0	0	0	0	0	1	11221	900	32	1		1	OR7E24	19	9362193	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	64912	9362193	49766790	1269	20302										
ZNF560	147741	broad.mit.edu	37	chr19	9578284	9578284	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aactctcaaatgtccaaaaaGagatgggtaagaaataaagg	9	5	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9578284G>C	uc002mlp.1	-	10	1549	c.1339C>G	c.(1339-1341)CTT>GTT	p.L447V	ZNF560_uc010dwr.1_Missense_Mutation_p.L341V	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	447	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TGTCCAAAAAGAGATGGGTAA	0.403													0	0	0	1	0	32	101										C	9578284	G	C	9578284	3	2	65	1	0	0	0	0	1	0	0	0	17988	942	33	1	1037	1	ZNF560	19	9578284	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	216091	9578284	49550699	1270	20303										
ZNF426	79088	broad.mit.edu	37	chr19	9639182	9639182	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctaaaggaactggaacacgtGaaggctttcccacactcctt	8	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9639182G>A	uc002mlq.2	-	8	1803	c.1539C>T	c.(1537-1539)TTC>TTT	p.F513F	ZNF426_uc010dws.2_Silent_p.F475F	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	513	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGGAACACGTGAAGGCTTTCC	0.428													0	0	0	1	0	22	81										A	9639182	G	A	9639182	2	1	65	1	0	0	0	0	0	0	0	1	17897	1281	45	1		1	ZNF426	19	9639182	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	60898	9639182	49489801	1271	20304										
ZNF561	93134	broad.mit.edu	37	chr19	9727726	9727726	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgatgttactcttacccacaGaggccaggttcatgtagttc	9	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9727726G>A	uc002mlu.2	-	4	441	c.236C>T	c.(235-237)TCT>TTT	p.S79F	ZNF561_uc010dwu.2_Missense_Mutation_p.S10F|ZNF561_uc010xkr.1_5'UTR	NM_152289	NP_689502	Q8N587	ZN561_HUMAN	zinc finger protein 561	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTTACCCACAGAGGCCAGGTT	0.313													0	0	0	1	0	14	62										A	9727726	G	A	9727726	3	1	65	1	0	0	0	0	1	0	0	0	17989	942	33	1	1236	1	ZNF561	19	9727726	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	88544	9727726	49401257	1272	20305										
FBXL12	54850	broad.mit.edu	37	chr19	9921757	9921757	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtgggggagggcatttctgGggtgacgaggggaccctgca	20	7	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:9921757G>A	uc002mme.2	-	3	1038	c.796C>T	c.(796-798)CCA>TCA	p.P266S	FBXL12_uc002mmd.2_Missense_Mutation_p.P213S|FBXL12_uc002mmf.2_Missense_Mutation_p.P213S|FBXL12_uc002mmg.2_Missense_Mutation_p.P213S|FBXL12_uc002mmh.2_Missense_Mutation_p.P213S	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	266	LRR 8.						protein binding			lung(1)|kidney(1)	2						GGCATTTCTGGGGTGACGAGG	0.662													0	0	0	1	0	5	24										A	9921757	G	A	9921757	3	1	65	1	0	0	0	0	1	0	0	0	5708	1232	43	2	188	2	FBXL12	19	9921757	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	194031	9921757	49207226	1273	20306										
DNMT1	1786	broad.mit.edu	37	chr19	10246920	10246920	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggggcaggcaccaggggatGagggtgttgaactgcctggc	19	8	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:10246920G>A	uc002mng.2	-	37	4665	c.4485C>T	c.(4483-4485)CTC>CTT	p.L1495L	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Silent_p.L419L|DNMT1_uc010xlc.1_Silent_p.L1511L|DNMT1_uc002mnh.2_Silent_p.L1390L|DNMT1_uc010xld.1_Silent_p.L1498L	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1495	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	ACCAGGGGATGAGGGTGTTGA	0.627													0	0	0	1	0	9	34										A	10246920	G	A	10246920	2	1	65	1	0	0	0	0	0	0	0	1	4675	1277	45	1		1	DNMT1	19	10246920	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	325163	10246920	48882063	1274	20307										
PRKCSH	5589	broad.mit.edu	37	chr19	11558333	11558333	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagccgccagtgccctcgtCgcccacagaggaggaggagg	16	14	0	1	rs142627856		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:11558333C>T	uc002mrt.2	+	11	1265	c.929C>T	c.(928-930)TCG>TTG	p.S310L	PRKCSH_uc002mru.2_Missense_Mutation_p.S310L|PRKCSH_uc010xlz.1_Missense_Mutation_p.S310L|PRKCSH_uc010dya.2_Intron|PRKCSH_uc002mrv.1_Missense_Mutation_p.S310L|PRKCSH_uc010dyb.2_Missense_Mutation_p.S310L	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	310					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						GTGCCCTCGTCGCCCACAgag	0.463													0	0	0	1	0	6	35										T	11558333	C	T	11558333	3	4	65	1	0	0	0	0	1	0	0	0	12516	893	31	1	967	1	PRKCSH	19	11558333	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1311413	11558333	47570650	1275	20308										
ACP5	54	broad.mit.edu	37	chr19	11687567	11687567	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tagagtatgcaatctgggcaGagacattgccaaggtggtca	13	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:11687567G>A	uc002msg.3	-	3	499	c.353C>T	c.(352-354)TCT>TTT	p.S118F	ACP5_uc002msh.3_Missense_Mutation_p.S118F|ACP5_uc002msi.3_Missense_Mutation_p.S118F|ACP5_uc002msj.3_Missense_Mutation_p.S118F|ACP5_uc010dye.1_3'UTR	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	118					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						AATCTGGGCAGAGACATTGCC	0.572													0	0	0	1	0	42	131										A	11687567	G	A	11687567	3	1	65	1	0	0	0	0	1	0	0	0	164	942	33	1	636	1	ACP5	19	11687567	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	129234	11687567	47441416	1276	20309										
ZNF491	126069	broad.mit.edu	37	chr19	11917627	11917627	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttactctcccagttcatttCaaaggcatgaaagaagtcac	6	10	4	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:11917627C>T	uc002mso.1	+	3	1144	c.859C>T	c.(859-861)CAA>TAA	p.Q287*		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	287	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAGTTCATTTCAAAGGCATGA	0.423													0	0	0	1	0	8	44										T	11917627	C	T	11917627	4	4	65	1	0	0	0	0	0	1	0	0	17939	827	29	1	861	1	ZNF491	19	11917627	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	230060	11917627	47211356	1277	20310										
ZNF700	90592	broad.mit.edu	37	chr19	12059829	12059829	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catgaaaggacccactctggGaaaaaaccgtatgaatgtaa	9	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12059829G>C	uc002msu.2	+	4	1116	c.990G>C	c.(988-990)GGG>GGC	p.G330G	ZNF700_uc010xme.1_Silent_p.G348G|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCCACTCTGGGAAAAAACCGT	0.373													0	0	0	1	0	20	57										C	12059829	G	C	12059829	2	2	65	1	0	0	0	0	0	0	0	1	18101	1161	41	1		1	ZNF700	19	12059829	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	142202	12059829	47069154	1278	20311										
FBXW9	84261	broad.mit.edu	37	chr19	12800989	12800989	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaaggccccccccagcccatGagagcatcccgggtctccat	10	18	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12800989G>C	uc010dyx.2	-	6	879	c.879C>G	c.(877-879)CTC>CTG	p.L293L	FBXW9_uc010xmp.1_Intron|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Intron|FBXW9_uc002mun.1_Intron	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	303							protein binding			ovary(1)	1						CCCAGCCCATGAGAGCATCCC	0.612													0	0	0	1	0	15	19										C	12800989	G	C	12800989	2	2	65	1	0	0	0	0	0	0	0	1	5771	1305	45	1		1	FBXW9	19	12800989	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	741160	12800989	46327994	1279	20312										
FBXW9	84261	broad.mit.edu	37	chr19	12807065	12807065	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atggtcagacacgaggtcgcGgagcgcgtggcacacccgcg	16	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12807065G>C	uc010dyx.2	-	1	331	c.331C>G	c.(331-333)CGC>GGC	p.R111G	FBXW9_uc010xmp.1_RNA|FBXW9_uc002mum.1_Missense_Mutation_p.R111G|FBXW9_uc002mun.1_5'UTR	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	111	F-box.						protein binding			ovary(1)	1						ACGAGGTCGCGGAGCGCGTGG	0.622													0	0	0	1	0	5	10										C	12807065	G	C	12807065	3	2	65	1	0	0	0	0	1	0	0	0	5771	1116	39	4	1085	4	FBXW9	19	12807065	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	6076	12807065	46321918	1280	20313										
HOOK2	29911	broad.mit.edu	37	chr19	12885536	12885536	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgccctggagccatgcctCgttgaaccaggaggggtctc	14	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12885536C>T	uc002muy.2	-	3	322	c.151G>A	c.(151-153)GAG>AAG	p.E51K	HOOK2_uc002muz.2_Missense_Mutation_p.E51K|HOOK2_uc002mva.2_Missense_Mutation_p.E51K	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	51	Sufficient for interaction with microtubules.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						AGCCATGCCTCGTTGAACCAG	0.567													0	0	0	1	0	14	39										T	12885536	C	T	12885536	3	4	65	1	0	0	0	0	1	0	0	0	7283	893	31	1	2092	1	HOOK2	19	12885536	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	78471	12885536	46243447	1281	20314										
PRDX2	7001	broad.mit.edu	37	chr19	12911749	12911749	+	Nonsense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccaagccaggtgggtgaactGagagtccaccgagacgccca							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12911749G>A	uc002mvd.2	-	3	388	c.238C>T	c.(238-240)CAG>TAG	p.Q80*	PRDX2_uc002mve.1_Nonsense_Mutation_p.Q80*	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	80	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						TGGGTGAACTGAGAGTCCACC	0.348													0	0	0	1	0	5	24										A	12911749	G	A	12911749	4	1	65	1	0	0	0	0	0	1	0	0	12465	1299	45	1	546	1	PRDX2	19	12911749	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	26213	12911749	46217234	1282	20315	101	3								
PRDX2	7001	broad.mit.edu	37	chr19	12911751	12911751	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagccaggtgggtgaactgaGagtccaccgagacgcccagc							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12911751G>A	uc002mvd.2	-	3	386	c.236C>T	c.(235-237)TCT>TTT	p.S79F	PRDX2_uc002mve.1_Missense_Mutation_p.S79F	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	79	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						GGTGAACTGAGAGTCCACCGA	0.353													0	0	0	1	0	6	25										A	12911751	G	A	12911751	3	1	65	1	0	0	0	0	1	0	0	0	12465	942	33	1	548	1	PRDX2	19	12911751	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2	12911751	46217232	1283	20316	101	3								
PRDX2	7001	broad.mit.edu	37	chr19	12911760	12911760	+	Missense_Mutation	SNP	G	G	A													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggtgaactgagagtccaccGagacgcccagcacttcacag							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:12911760G>A	uc002mvd.2	-	3	377	c.227C>T	c.(226-228)TCG>TTG	p.S76L	PRDX2_uc002mve.1_Missense_Mutation_p.S76L	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	76	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						AGAGTCCACCGAGACGCCCAG	0.378													0	0	0	1	0	7	31										A	12911760	G	A	12911760	3	1	65	1	0	0	0	0	1	0	0	0	12465	1059	37	1	557	1	PRDX2	19	12911760	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	9	12911760	46217223	1284	20317	101	3								
STX10	8677	broad.mit.edu	37	chr19	13260331	13260331	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acctggactgcctctcgcatCcgctccacgaacacctttct	6	18	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:13260331C>G	uc010xnb.1	-	3	282	c.282G>C	c.(280-282)CGG>CGC	p.R94R	STX10_uc002mwn.2_5'UTR|STX10_uc002mwo.2_5'UTR|STX10_uc010xna.1_Intron|STX10_uc010xnc.1_Intron|IER2_uc002mwr.2_5'Flank	NM_003765	NP_003756	O60499	STX10_HUMAN	syntaxin 10	94	Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane	SNAP receptor activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			CCTCTCGCATCCGCTCCACGA	0.502													0	0	0	1	0	32	91										G	13260331	C	G	13260331	2	3	65	1	0	0	0	0	0	0	0	1	15335	842	30	1		1	STX10	19	13260331	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	348571	13260331	45868652	1285	20318										
CACNA1A	773	broad.mit.edu	37	chr19	13476255	13476255	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agcaaagggatcatcgccttCatgatcgacttcaggacgac	10	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:13476255C>T	uc010dze.2	-	5	896	c.660G>A	c.(658-660)ATG>ATA	p.M220I	CACNA1A_uc002mwy.3_Missense_Mutation_p.M220I	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	220	Cytoplasmic (Potential).|I.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TCATCGCCTTCATGATCGACT	0.478													0	0	0	1	0	16	50										T	13476255	C	T	13476255	3	4	65	1	0	0	0	0	1	0	0	0	2538	826	29	1	7146	1	CACNA1A	19	13476255	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	215924	13476255	45652728	1286	20319										
CCDC130	81576	broad.mit.edu	37	chr19	13869691	13869691	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctccctcccaggttccggatGaaatgccacctctgtgtcaa	8	15	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:13869691G>T	uc002mxb.1	+	8	770	c.267G>T	c.(265-267)ATG>ATT	p.M89I	CCDC130_uc010xnf.1_Missense_Mutation_p.M89I|CCDC130_uc002mxc.1_Missense_Mutation_p.M89I|CCDC130_uc002mxd.1_5'UTR|CCDC130_uc010dzf.1_Intron	NM_030818	NP_110445	P13994	CC130_HUMAN	coiled-coil domain containing 130	89					response to virus		protein binding				0			OV - Ovarian serous cystadenocarcinoma(19;6.02e-23)|Epithelial(5;2.58e-18)			GGTTCCGGATGAAATGCCACC	0.632													1	0	1.26484e-09	1	1.3194e-09	6	25										T	13869691	G	T	13869691	3	4	65	1	0	0	0	0	1	0	0	0	2766	1290	45	3	289	3	CCDC130	19	13869691	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	393436	13869691	45259292	1287	20320										
CYP4F22	126410	broad.mit.edu	37	chr19	15662126	15662126	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aattgcatcggacagagcttCgccatggccgagttgcgcgt	13	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:15662126C>T	uc002nbh.3	+	14	1607	c.1440C>T	c.(1438-1440)TTC>TTT	p.F480F		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	480						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GACAGAGCTTCGCCATGGCCG	0.617													0	0	0	1	0	8	21										T	15662126	C	T	15662126	2	4	65	1	0	0	0	0	0	0	0	1	4189	883	31	1		1	CYP4F22	19	15662126	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1792435	15662126	43466857	1288	20321										
CYP4F2	8529	broad.mit.edu	37	chr19	16000358	16000358	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gatgacggcatctgtgaagtCgtgcaccaggcggcaggccc	15	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:16000358C>T	uc002nbs.1	-	7	843	c.793G>A	c.(793-795)GAC>AAC	p.D265N	CYP4F2_uc010xot.1_Missense_Mutation_p.D116N|CYP4F2_uc010xou.1_Missense_Mutation_p.D116N	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	265					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						TCTGTGAAGTCGTGCACCAGG	0.547													0	0	0	1	0	68	156										T	16000358	C	T	16000358	3	4	65	1	0	0	0	0	1	0	0	0	4188	884	31	1	797	1	CYP4F2	19	16000358	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	338232	16000358	43128625	1289	20322										
MAST3	23031	broad.mit.edu	37	chr19	18239752	18239752	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	catcaaactcattagcaacgGagcctatgggtgagtccctg	10	11	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:18239752G>C	uc002nhz.3	+	12	1127	c.1127G>C	c.(1126-1128)GGA>GCA	p.G376A		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	376	ATP (By similarity).|Protein kinase.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						ATTAGCAACGGAGCCTATGGG	0.597													0	0	0	1	0	18	79										C	18239752	G	C	18239752	3	2	65	1	0	0	0	0	1	0	0	0	9326	1174	41	1	1173	1	MAST3	19	18239752	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2239394	18239752	40889231	1290	20323										
CRTC1	23373	broad.mit.edu	37	chr19	18876304	18876304	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcaaggcgtcagcaggcatCgcccaccctgtccccgctgt	12	17	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:18876304C>T	uc002nkb.3	+	9	1065	c.977C>T	c.(976-978)TCG>TTG	p.S326L	CRTC1_uc010ebv.2_Missense_Mutation_p.S342L|CRTC1_uc010ebw.2_Missense_Mutation_p.S191L|CRTC1_uc002nkc.3_Missense_Mutation_p.S191L	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	326	Ser-rich.				interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						CAGCAGGCATCGCCCACCCTG	0.662													0	0	0	1	0	37	115										T	18876304	C	T	18876304	3	4	65	1	0	0	0	0	1	0	0	0	3899	893	31	1	1063	1	CRTC1	19	18876304	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	636552	18876304	40252679	1291	20324										
COMP	1311	broad.mit.edu	37	chr19	18896558	18896558	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acgactgtctggaaggccctGaagtcggtgagcgtgacttc	14	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:18896558G>A	uc002nke.2	-	14	1629	c.1593C>T	c.(1591-1593)TTC>TTT	p.F531F	COMP_uc002nkd.2_Silent_p.F498F|COMP_uc010xqj.1_Silent_p.F478F	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	531	Mediates cell survival and induction of the IAP family of survival proteins.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						GGAAGGCCCTGAAGTCGGTGA	0.632													0	0	0	1	0	28	65										A	18896558	G	A	18896558	2	1	65	1	0	0	0	0	0	0	0	1	3724	1281	45	1		1	COMP	19	18896558	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	20254	18896558	40232425	1292	20325										
UPF1	5976	broad.mit.edu	37	chr19	18965463	18965463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagcgtgggtgcacctgtgGaggtgactcacaacttccag	14	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:18965463G>A	uc002nkg.2	+	9	1518	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	UPF1_uc002nkf.2_Missense_Mutation_p.E404K	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	415	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGCACCTGTGGAGGTGACTCA	0.547													0	0	0	1	0	69	202										A	18965463	G	A	18965463	3	1	65	1	0	0	0	0	1	0	0	0	17000	1175	41	1	1244	1	UPF1	19	18965463	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	68905	18965463	40163520	1293	20326										
ZNF253	56242	broad.mit.edu	37	chr19	20003061	20003061	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atacataagagaattcatacAggagagaaaccctacaaatg	7	7	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:20003061A>T	uc002noj.2	+	4	1097	c.1005A>T	c.(1003-1005)ACA>ACT	p.T335T	ZNF253_uc002nok.2_Silent_p.T259T|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	335				Missing (in Ref. 1; AAC26844).	negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATTCATACAGGAGAGAAAC	0.383													0	0	0	1	0	5	48										T	20003061	A	T	20003061	2	4	65	1	0	0	0	0	0	0	0	1	17794	175	7	5		5	ZNF253	19	20003061	Silent	SNP	A	TCGA-DK-A3WW-01A-22D-A23M-08	1037598	20003061	39125922	1294	20327										
GRAMD1A	57655	broad.mit.edu	37	chr19	35517044	35517044	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcccgatgacagcttttcctGaggaccccggccacgcagct	11	16	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:35517044G>A	uc010xse.1	+	20	2311	c.2174G>A	c.(2173-2175)TGA>TAA	p.*725*	GRAMD1A_uc002nxk.2_Silent_p.*714*|GRAMD1A_uc002nxl.2_Silent_p.*487*|GRAMD1A_uc010xsf.1_Silent_p.*726*|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Silent_p.*336*	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	725						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			AGCTTTTCCTGAGGACCCCGG	0.637													0	0	0	1	0	19	62										A	35517044	G	A	35517044	2	1	65	1	0	0	0	0	0	0	0	1	6747	1285	45	1		1	GRAMD1A	19	35517044	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	15513983	35517044	23611939	1295	20328										
LGI4	163175	broad.mit.edu	37	chr19	35616111	35616111	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtggtctcaggcactgaggtCgatctcgtgatgctggtaga	15	8	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:35616111C>G	uc002nxx.2	-	9	2194	c.1600G>C	c.(1600-1602)GAC>CAC	p.D534H	LGI4_uc002nxy.1_Missense_Mutation_p.D362H|LGI4_uc002nxz.1_3'UTR	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	534						extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GCACTGAGGTCGATCTCGTGA	0.647													0	0	0	1	0	18	58										G	35616111	C	G	35616111	3	3	65	1	0	0	0	0	1	0	0	0	8754	884	31	1	17	1	LGI4	19	35616111	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	99067	35616111	23512872	1296	20329										
RBM42	79171	broad.mit.edu	37	chr19	36120478	36120478	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatcccaactgctgtgcctgCggtgcccactgtccccacgg	10	17	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:36120478C>T	uc002oan.2	+	2	261	c.185C>T	c.(184-186)GCG>GTG	p.A62V	RBM42_uc010xsx.1_Missense_Mutation_p.A62V|RBM42_uc010eef.2_Missense_Mutation_p.A62V|RBM42_uc002oao.2_Missense_Mutation_p.A62V|RBM42_uc002oap.2_Missense_Mutation_p.A62V|RBM42_uc002oaq.2_Missense_Mutation_p.A62V|RBM42_uc010eeg.2_Missense_Mutation_p.A62V	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	62						cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCTGTGCCTGCGGTGCCCACT	0.587													0	0	0	1	0	39	125										T	36120478	C	T	36120478	3	4	65	1	0	0	0	0	1	0	0	0	13136	768	27	2	191	2	RBM42	19	36120478	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	504367	36120478	23008505	1297	20330										
MLL4	9757	broad.mit.edu	37	chr19	36221766	36221766	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcacagccccgccccttcctCaggtgtggctttggctctgt	11	16	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:36221766C>G	uc010eei.2	+	27	5435	c.5435C>G	c.(5434-5436)TCA>TGA	p.S1812*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1812					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCCCCTTCCTCAGGTGTGGCT	0.572													0	0	0	1	0	9	12										G	36221766	C	G	36221766	4	3	65	1	0	0	0	0	0	1	0	0	9623	838	29	1	5537	1	MLL4	19	36221766	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	101288	36221766	22907217	1298	20331										
ZNF529	57711	broad.mit.edu	37	chr19	37038408	37038408	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctgatgttcaatgagctgtGaactaattctaaaaaccttc	6	8	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:37038408G>A	uc002oeh.3	-	5	1254	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L	ZNF529_uc010xth.1_Missense_Mutation_p.S351L|ZNF529_uc010xti.1_Missense_Mutation_p.S333L|ZNF529_uc002oeg.3_Missense_Mutation_p.S246L	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	318	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					AATGAGCTGTGAACTAATTCT	0.398													0	0	0	1	0	19	46										A	37038408	G	A	37038408	3	1	65	1	0	0	0	0	1	0	0	0	17967	1294	45	1	643	1	ZNF529	19	37038408	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	816642	37038408	22090575	1299	20332										
ZNF461	92283	broad.mit.edu	37	chr19	37130859	37130859	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggactatggcttttaaattCttccatgttaacccactggg	8	9	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:37130859C>G	uc002oem.2	-	6	616	c.388G>C	c.(388-390)GAA>CAA	p.E130Q	ZNF461_uc002oen.2_Missense_Mutation_p.E99Q|ZNF461_uc010xtj.1_Missense_Mutation_p.E107Q	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CTTTTAAATTCTTCCATGTTA	0.403													0	0	0	1	0	48	108										G	37130859	C	G	37130859	3	3	65	1	0	0	0	0	1	0	0	0	17922	922	32	1	1307	1	ZNF461	19	37130859	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	92451	37130859	21998124	1300	20333										
ZNF567	163081	broad.mit.edu	37	chr19	37210440	37210440	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aatcagtattgattctgcatCagggaattcactcagaagaa	8	7	5	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:37210440C>A	uc010xtl.1	+	6	1036	c.814C>A	c.(814-816)CAG>AAG	p.Q272K	ZNF567_uc002oeo.1_Missense_Mutation_p.Q272K|ZNF567_uc010xtk.1_Missense_Mutation_p.Q272K|ZNF567_uc002oep.3_Missense_Mutation_p.Q241K|ZNF567_uc002oeq.1_Missense_Mutation_p.Q241K	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	272	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GATTCTGCATCAGGGAATTCA	0.333													1	0	4.096e-09	1	4.26478e-09	6	22										A	37210440	C	A	37210440	3	1	65	1	0	0	0	0	1	0	0	0	17995	827	29	3	731	3	ZNF567	19	37210440	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	79581	37210440	21918543	1301	20334										
ZNF568	374900	broad.mit.edu	37	chr19	37441842	37441842	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	taaatgtgggaaagccttttCtcagtgctcattacttatta	7	7	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:37441842C>G	uc002ofc.2	+	7	2302	c.1787C>G	c.(1786-1788)TCT>TGT	p.S596C	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.S520C|ZNF568_uc010efe.2_Missense_Mutation_p.S520C|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	596	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAAGCCTTTTCTCAGTGCTCA	0.403													0	0	0	1	0	19	72										G	37441842	C	G	37441842	3	3	65	1	0	0	0	0	1	0	0	0	17996	913	32	1	1805	1	ZNF568	19	37441842	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	231402	37441842	21687141	1302	20335										
ZNF607	84775	broad.mit.edu	37	chr19	38200664	38200664	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaggtcttctgaaccaggctGagatattcccactcctgatg	9	11	2	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:38200664G>A	uc002ohc.1	-	3	665	c.69C>T	c.(67-69)CTC>CTT	p.L23L	ZNF607_uc002ohb.1_Silent_p.L23L	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	23	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GAACCAGGCTGAGATATTCCC	0.418													0	0	0	1	0	18	59										A	38200664	G	A	38200664	2	1	65	1	0	0	0	0	0	0	0	1	18030	1277	45	1		1	ZNF607	19	38200664	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	758822	38200664	20928319	1303	20336										
SIPA1L3	23094	broad.mit.edu	37	chr19	38610244	38610244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caaaagcacgggctggcgctGagcagcacagtgcaggggcc	16	12	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:38610244G>C	uc002ohk.2	+	9	3099	c.2590G>C	c.(2590-2592)GAG>CAG	p.E864Q		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	864					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GGCTGGCGCTGAGCAGCACAG	0.557													0	0	0	1	0	33	76										C	38610244	G	C	38610244	3	2	65	1	0	0	0	0	1	0	0	0	14331	1291	45	1	2616	1	SIPA1L3	19	38610244	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	409580	38610244	20518739	1304	20337										
YIF1B	90522	broad.mit.edu	37	chr19	38799901	38799901	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agaacagcaggcccagctttCtgcccacatacatggtgtcc	9	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:38799901C>A	uc002ohz.2	-	3	414	c.365G>T	c.(364-366)AGA>ATA	p.R122I	YIF1B_uc002ohw.2_Missense_Mutation_p.R91I|YIF1B_uc002ohx.2_Missense_Mutation_p.R107I|YIF1B_uc010xtx.1_Missense_Mutation_p.R105I|YIF1B_uc010xty.1_Missense_Mutation_p.R91I|YIF1B_uc002oia.2_Missense_Mutation_p.R119I|YIF1B_uc002ohy.2_Missense_Mutation_p.R119I|YIF1B_uc002oib.2_Missense_Mutation_p.R119I	NM_001039672	NP_001034761	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B isoform 5	122	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCCCAGCTTTCTGCCCACATA	0.597													1	0	4.03997e-35	1	4.31797e-35	73	246										A	38799901	C	A	38799901	3	1	65	1	0	0	0	0	1	0	0	0	17473	913	32	3	684	3	YIF1B	19	38799901	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	189657	38799901	20329082	1305	20338										
NFKBIB	4793	broad.mit.edu	37	chr19	39398291	39398291	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagcgacagcgacagcggaGacgagggcgtgagtcaggag	19	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:39398291G>C	uc002ojw.2	+	5	1019	c.961G>C	c.(961-963)GAC>CAC	p.D321H	NFKBIB_uc002ojx.2_Missense_Mutation_p.D289H|NFKBIB_uc002ojy.2_Missense_Mutation_p.D321H	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	321					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CGACAGCGGAGACGAGGGCGT	0.652													0	0	0	1	0	5	24										C	39398291	G	C	39398291	3	2	65	1	0	0	0	0	1	0	0	0	10378	942	33	1	979	1	NFKBIB	19	39398291	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	598390	39398291	19730692	1306	20339										
SARS2	54938	broad.mit.edu	37	chr19	39435635	39435635	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcagcccctctcagtccactGaaggaccgggtcaggtgagg	14	13	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:39435635G>T	uc010xuq.1	-	4	380	c.172C>A	c.(172-174)CAG>AAG	p.Q58K	FBXO17_uc002okg.1_Missense_Mutation_p.Q223K|FBXO17_uc002okf.1_Missense_Mutation_p.Q232K	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	Error:Variant_position_missing_in_Q9NP81_after_alignment					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TCAGTCCACTGAAGGACCGGG	0.612													1	0	7.33532e-06	1	7.51282e-06	24	112										T	39435635	G	T	39435635	3	4	65	1	0	0	0	0	1	0	0	0	13845	1299	45	3		3	SARS2	19	39435635	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	37344	39435635	19693348	1307	20340										
ZFP36	7538	broad.mit.edu	37	chr19	39899334	39899334	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcaatcgcatctctgtttctGagtgacaaagtgactgcccg	9	11	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:39899334G>A	uc002olh.1	+	2	1034	c.976G>A	c.(976-978)GAG>AAG	p.E326K	ZFP36_uc010egn.1_Silent_p.L198L	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	326					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTCTGTTTCTGAGTGACAAAG	0.617													0	0	0	1	0	16	70										A	39899334	G	A	39899334	3	1	65	1	0	0	0	0	1	0	0	0	17642	1291	45	1	982	1	ZFP36	19	39899334	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	463699	39899334	19229649	1308	20341										
HIPK4	147746	broad.mit.edu	37	chr19	40889768	40889768	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggtgggggttgcgcttgaaGaagtggtgggccttgcaggc	21	6	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:40889768G>A	uc002onp.2	-	2	1029	c.744C>T	c.(742-744)TTC>TTT	p.F248F		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	248	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TGCGCTTGAAGAAGTGGTGGG	0.627													0	0	0	1	0	11	97										A	40889768	G	A	40889768	2	1	65	1	0	0	0	0	0	0	0	1	7119	933	33	1		1	HIPK4	19	40889768	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	990434	40889768	18239215	1309	20342										
ITPKC	80271	broad.mit.edu	37	chr19	41235160	41235160	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaaacgtttctgtcagtgtGagcagcgcagcctggagcag	14	9	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:41235160G>C	uc002oot.2	+	3	1342	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q		NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	437						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CTGTCAGTGTGAGCAGCGCAG	0.532													0	0	0	1	0	14	56										C	41235160	G	C	41235160	3	2	65	1	0	0	0	0	1	0	0	0	7919	1291	45	1	1319	1	ITPKC	19	41235160	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	345392	41235160	17893823	1310	20343										
CYP2A13	1553	broad.mit.edu	37	chr19	41596470	41596470	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggcaacctccacggggcagGtaactggctgcagcccgcca	13	16	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:41596470G>T	uc002opt.2	+	4	663	c.654_splice	c.e4+1	p.Q218_splice		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	CACGGGGCAGGTAACTGGCTG	0.597													1	0	2.23348e-06	1	2.29586e-06	15	103										T	41596470	G	T	41596470	5	4	65	1	0	0	0	0	0	0	1	0	4161	1275	44	4	669	4	CYP2A13	19	41596470	Splice_Site	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	361310	41596470	17532513	1311	20344										
ZNF526	116115	broad.mit.edu	37	chr19	42728670	42728670	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agatgtcaacagaagtgactGagatgacacctggggaggcc	14	8	1	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:42728670G>A	uc002osz.1	+	3	271	c.115G>A	c.(115-117)GAG>AAG	p.E39K		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				AGAAGTGACTGAGATGACACC	0.542													0	0	0	1	0	49	123										A	42728670	G	A	42728670	3	1	65	1	0	0	0	0	1	0	0	0	17964	1291	45	1	117	1	ZNF526	19	42728670	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1132200	42728670	16400313	1312	20345										
CIC	23152	broad.mit.edu	37	chr19	42797160	42797160	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aaggcccagcggcccagcccGaaggccccccagaaagtgaa	12	16	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:42797160G>A	uc002otf.1	+	15	3562	c.3522G>A	c.(3520-3522)CCG>CCA	p.P1174P		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1174	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				GGCCCAGCCCGAAGGCCCCCC	0.652			T	DUX4	soft tissue sarcoma								0	0	0	1	0	14	59										A	42797160	G	A	42797160	2	1	65	1	0	0	0	0	0	0	0	1	3424	1045	37	1		1	CIC	19	42797160	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	68490	42797160	16331823	1313	20346										
TMEM145	284339	broad.mit.edu	37	chr19	42828958	42828958	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccggccccctggcccccttCgagacctctgaccccgctgg	10	21	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:42828958C>G	uc002otk.1	+	15	1523	c.1471C>G	c.(1471-1473)CGA>GGA	p.R491G	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	491						integral to membrane					0		Prostate(69;0.00682)				TGGCCCCCTTCGAGACCTCTG	0.716													0	0	0	1	0	8	27										G	42828958	C	G	42828958	3	3	65	1	0	0	0	0	1	0	0	0	16056	876	31	1	1529	1	TMEM145	19	42828958	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	31798	42828958	16300025	1314	20347										
MEGF8	1954	broad.mit.edu	37	chr19	42863100	42863100	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaggaaatctcacctcacctGaaggaggtgagatttgaaga	12	7	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:42863100G>A	uc002otl.3	+	29	5771	c.5136G>A	c.(5134-5136)CTG>CTA	p.L1712L	MEGF8_uc002otm.3_Silent_p.L1320L	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1779	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CACCTCACCTGAAGGAGGTGA	0.577													0	0	0	1	0	5	16										A	42863100	G	A	42863100	2	1	65	1	0	0	0	0	0	0	0	1	9463	1277	45	1		1	MEGF8	19	42863100	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	34142	42863100	16265883	1315	20348										
KCNN4	3783	broad.mit.edu	37	chr19	44273668	44273668	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcctgcgagtatgtttgtaGaacatccaggcttcttgtag	10	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:44273668G>C	uc002oxl.2	-	6	1371	c.975C>G	c.(973-975)TTC>TTG	p.F325L	KCNN4_uc010eiz.2_Intron	NM_002250	NP_002241	O15554	KCNN4_HUMAN	intermediate conductance calcium-activated	325	Calmodulin-binding.				defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	TATGTTTGTAGAACATCCAGG	0.592													0	0	0	1	0	50	127										C	44273668	G	C	44273668	3	2	65	1	0	0	0	0	1	0	0	0	8081	933	33	1	320	1	KCNN4	19	44273668	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1410568	44273668	14855315	1316	20349										
ZNF283	284349	broad.mit.edu	37	chr19	44351774	44351774	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgctaaacatgagataattCatacaggtgagaaaccttat	7	6	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:44351774C>T	uc002oxr.3	+	7	1289	c.1021C>T	c.(1021-1023)CAT>TAT	p.H341Y	ZNF283_uc002oxp.3_Missense_Mutation_p.H202Y	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGAGATAATTCATACAGGTGA	0.393													0	0	0	1	0	19	49										T	44351774	C	T	44351774	3	4	65	1	0	0	0	0	1	0	0	0	17817	826	29	1	1035	1	ZNF283	19	44351774	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	78106	44351774	14777209	1317	20350										
MARK4	57787	broad.mit.edu	37	chr19	45781258	45781258	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gactgtgagagcatcctgcgGagatttttggtgctgaaccc	13	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:45781258G>A	uc002pbb.1	+	9	869	c.864G>A	c.(862-864)CGG>CGA	p.R288R	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.R288R|MARK4_uc002pbc.1_Silent_p.R154R			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	288	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GCATCCTGCGGAGATTTTTGG	0.572													0	0	0	1	0	45	102										A	45781258	G	A	45781258	2	1	65	1	0	0	0	0	0	0	0	1	9315	1161	41	1		1	MARK4	19	45781258	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1429484	45781258	13347725	1318	20351										
DMWD	1762	broad.mit.edu	37	chr19	46294229	46294229	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tactgcacttgacccgctgaGaagcccaccagcagcgagat	10	14	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:46294229G>C	uc002pdj.1	-	2	604	c.558C>G	c.(556-558)TTC>TTG	p.F186L	DMWD_uc002pdk.1_Missense_Mutation_p.F186L	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	186					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		GACCCGCTGAGAAGCCCACCA	0.562													0	0	0	1	0	40	108										C	46294229	G	C	46294229	3	2	65	1	0	0	0	0	1	0	0	0	4593	933	33	1	1482	1	DMWD	19	46294229	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	512971	46294229	12834754	1319	20352										
IGFL1	374918	broad.mit.edu	37	chr19	46733686	46733686	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaccttcagagtctgctttGagcagtgctgcccctggacc	11	14	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:46733686G>C	uc002pee.2	+	3	258	c.235G>C	c.(235-237)GAG>CAG	p.E79Q		NM_198541	NP_940943	Q6UW32	IGFL1_HUMAN	IGF-like family member 1 precursor	79						extracellular space	protein binding				0		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.00242)|all cancers(93;0.0132)|GBM - Glioblastoma multiforme(486;0.0294)|Epithelial(262;0.201)		AGTCTGCTTTGAGCAGTGCTG	0.572													0	0	0	1	0	40	145										C	46733686	G	C	46733686	3	2	65	1	0	0	0	0	1	0	0	0	7586	1291	45	1	245	1	IGFL1	19	46733686	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	439457	46733686	12395297	1320	20353										
STRN4	29888	broad.mit.edu	37	chr19	47224014	47224014	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtccaggctccagagacgcaGggagcagtcatggcctgcac	14	13	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:47224014G>C	uc002pfl.2	-	17	2140	c.2107C>G	c.(2107-2109)CTG>GTG	p.L703V	STRN4_uc002pfm.2_Missense_Mutation_p.L710V|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	703	WD 6.					cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		CAGAGACGCAGGGAGCAGTCA	0.637													0	0	0	1	0	10	57										C	47224014	G	C	47224014	3	2	65	1	0	0	0	0	1	0	0	0	15330	991	35	4	158	4	STRN4	19	47224014	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	490328	47224014	11904969	1321	20354										
GRIN2D	2906	broad.mit.edu	37	chr19	48908550	48908550	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcgtgattatggtttccttcCtgagctcggccacgactgtc	11	12	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:48908550C>G	uc002pjc.3	+	3	1113	c.1025C>G	c.(1024-1026)CCT>CGT	p.P342R		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	342	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GGTTTCCTTCCTGAGCTCGGC	0.682													0	0	0	1	0	6	17										G	48908550	C	G	48908550	3	3	65	1	0	0	0	0	1	0	0	0	6782	681	24	4	1031	4	GRIN2D	19	48908550	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1684536	48908550	10220433	1322	20355										
HRC	3270	broad.mit.edu	37	chr19	49656911	49656911	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcctcctcctggttcaggctGaggccatgaccttcctcctc	8	17	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:49656911G>A	uc002pmv.2	-	1	1771	c.1584C>T	c.(1582-1584)CTC>CTT	p.L528L		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	528					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GGTTCAGGCTGAGGCCATGAC	0.403													0	0	0	1	0	8	26										A	49656911	G	A	49656911	2	1	65	1	0	0	0	0	0	0	0	1	7352	1277	45	1		1	HRC	19	49656911	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	748361	49656911	9472072	1323	20356										
SCAF1	58506	broad.mit.edu	37	chr19	50155667	50155667	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccgccctctggctccacctCgtgtggtgaccgcgacagcc	12	18	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:50155667C>G	uc002poq.2	+	7	2145	c.2021C>G	c.(2020-2022)TCG>TGG	p.S674W		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	674	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GGCTCCACCTCGTGTGGTGAC	0.582													0	0	0	1	0	11	23										G	50155667	C	G	50155667	3	3	65	1	0	0	0	0	1	0	0	0	13868	893	31	1	2043	1	SCAF1	19	50155667	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	498756	50155667	8973316	1324	20357										
KLK5	25818	broad.mit.edu	37	chr19	51452191	51452191	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggacaatgagaggagacgttGatgggtctgacatctttagt	14	5	2	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:51452191G>A	uc002pue.2	-	5	734	c.516C>T	c.(514-516)ATC>ATT	p.I172I	KLK5_uc002puf.2_Silent_p.I172I|KLK5_uc002pug.2_Silent_p.I172I	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	172	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		AGGAGACGTTGATGGGTCTGA	0.537													0	0	0	1	0	22	85										A	51452191	G	A	51452191	2	1	65	1	0	0	0	0	0	0	0	1	8407	1280	45	1		1	KLK5	19	51452191	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1296524	51452191	7676792	1325	20358										
KLK5	25818	broad.mit.edu	37	chr19	51452357	51452357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acagggagtagtggccgagaCggactctgaaaactctgagg	15	8	2	3	rs117067639	byFrequency	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:51452357C>T	uc002pue.2	-	5	568	c.350G>A	c.(349-351)CGT>CAT	p.R117H	KLK5_uc002puf.2_Missense_Mutation_p.R117H|KLK5_uc002pug.2_Missense_Mutation_p.R117H	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	117	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		GTGGCCGAGACGGACTCTGAA	0.498													0	0	0	1	0	29	102										T	51452357	C	T	51452357	3	4	65	1	0	0	0	0	1	0	0	0	8407	536	19	2	543	2	KLK5	19	51452357	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	166	51452357	7676626	1326	20359										
GP6	51206	broad.mit.edu	37	chr19	55543735	55543735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gggcaccagggagctgggcaGagcctggagggagggcttgg	22	8	0	1	rs28385643		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:55543735G>C	uc002qik.2	-	3	125	c.97C>G	c.(97-99)CTG>GTG	p.L33V	GP6_uc002qil.2_Missense_Mutation_p.L33V|GP6_uc010esq.2_Missense_Mutation_p.L33V|RDH13_uc010esr.1_Intron	NM_016363	NP_057447	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet) isoform 2	33	Ig-like C2-type 1.|Extracellular (Potential).				enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GAGCTGGGCAGAGCCTGGAGG	0.716													0	0	0	1	0	13	22										C	55543735	G	C	55543735	3	2	65	1	0	0	0	0	1	0	0	0	6584	933	33	1	1789	1	GP6	19	55543735	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4091378	55543735	3585248	1327	20360										
NLRP5	126206	broad.mit.edu	37	chr19	56539034	56539034	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgtgggctctctcatctgcGtggccctgcagctgcaggac	13	15	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:56539034G>T	uc002qmj.2	+	7	1435	c.1435G>T	c.(1435-1437)GTG>TTG	p.V479L	NLRP5_uc002qmi.2_Missense_Mutation_p.V460L	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	479	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCTCATCTGCGTGGCCCTGCA	0.617													1	0	1.99824e-07	1	2.06659e-07	16	53										T	56539034	G	T	56539034	3	4	65	1	0	0	0	0	1	0	0	0	10480	1145	40	4	1461	4	NLRP5	19	56539034	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	995299	56539034	2589949	1328	20361										
PEG3	5178	broad.mit.edu	37	chr19	57333096	57333096	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttgttttcgccaccacagGaagggaaagatcccgcggag	13	11	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:57333096G>A	uc002qnu.2	-	4	943	c.592C>T	c.(592-594)CCT>TCT	p.P198S	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.P73S|ZIM2_uc002qnq.2_Missense_Mutation_p.P73S|ZIM2_uc010etp.2_Missense_Mutation_p.P73S|ZIM2_uc010ygs.1_Missense_Mutation_p.P73S|PEG3_uc002qnt.2_Missense_Mutation_p.P199S|PEG3_uc002qnv.2_Missense_Mutation_p.P198S|PEG3_uc002qnw.2_Missense_Mutation_p.P73S|PEG3_uc002qnx.2_Missense_Mutation_p.P72S|PEG3_uc010etr.2_Missense_Mutation_p.P198S	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	198					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCCACCACAGGAAGGGAAAGA	0.537													0	0	0	1	0	38	126										A	57333096	G	A	57333096	3	1	65	1	0	0	0	0	1	0	0	0	11720	1174	41	1	4193	1	PEG3	19	57333096	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	794062	57333096	1795887	1329	20362										
ZIM3	114026	broad.mit.edu	37	chr19	57646567	57646567	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtatggatttttttatgttGaatgaggtttttcttctgga	10	2	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:57646567G>A	uc002qnz.1	-	5	1524	c.1138C>T	c.(1138-1140)CAA>TAA	p.Q380*		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	380	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTTTTATGTTGAATGAGGTTT	0.373													0	0	0	1	0	27	97										A	57646567	G	A	57646567	4	1	65	1	0	0	0	0	0	1	0	0	17682	1299	45	1	284	1	ZIM3	19	57646567	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	313471	57646567	1482416	1330	20363										
ZNF543	125919	broad.mit.edu	37	chr19	57840340	57840340	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	accaacagattcacactggaGagaaaccctatgaatgcatc	7	11	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:57840340G>A	uc002qoi.1	+	4	1855	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCACACTGGAGAGAAACCCTA	0.517													0	0	0	1	0	24	83										A	57840340	G	A	57840340	3	1	65	1	0	0	0	0	1	0	0	0	17973	943	33	1	1524	1	ZNF543	19	57840340	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	193773	57840340	1288643	1331	20364										
ZNF552	79818	broad.mit.edu	37	chr19	58319728	58319728	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttgtgcctaaaaaatttctGacaaacctcacactcatatg	4	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:58319728G>C	uc002qqg.2	-	3	1074	c.904C>G	c.(904-906)CAG>GAG	p.Q302E	ZNF587_uc002qqb.2_Intron|ZNF552_uc010yhg.1_Missense_Mutation_p.Q298E	NM_024762	NP_079038	Q9H707	ZN552_HUMAN	zinc finger protein 552	302	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		AAAAATTTCTGACAAACCTCA	0.433													0	0	0	1	0	25	62										C	58319728	G	C	58319728	3	2	65	1	0	0	0	0	1	0	0	0	17981	1299	45	1	323	1	ZNF552	19	58319728	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	479388	58319728	809255	1332	20365										
C19orf18	147685	broad.mit.edu	37	chr19	58477903	58477903	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttagcagatacttactatatCatataggagattgccatccc	6	9	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr19:58477903C>A	uc002qqv.2	-	4	470	c.366G>T	c.(364-366)ATG>ATT	p.M122I		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	122	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		CTTACTATATCATATAGGAGA	0.348													1	0	0.0293803	1	0.0295198	7	22										A	58477903	C	A	58477903	3	1	65	1	0	0	0	0	1	0	0	0	1910	826	29	3	293	3	C19orf18	19	58477903	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	158175	58477903	651080	1333	20366										
UBOX5	22888	broad.mit.edu	37	chr20	3102035	3102035	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggatgctgaattacctgtcGagcagtccatatgtgtcagg	12	8	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:3102035G>A	uc002whw.2	-	3	1420	c.1250C>T	c.(1249-1251)TCG>TTG	p.S417L	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.S417L|UBOX5_uc002why.1_Missense_Mutation_p.S417L	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	417						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						ATTACCTGTCGAGCAGTCCAT	0.527													0	0	0	1	0	12	55										A	3102035	G	A	3102035	3	1	65	1	0	0	0	0	1	0	0	0	16891	1059	37	1	387	1	UBOX5	20	3102035	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		3102035	59923485	1334	20367										
CENPB	1059	broad.mit.edu	37	chr20	3765738	3765738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caagccctccgaggagctctCctcatcttcctcctcttctt	5	18	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:3765738C>T	uc002wjk.2	-	1	1600	c.1393G>A	c.(1393-1395)GAG>AAG	p.E465K	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	465	Glu-rich (acidic).				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						GAGGAGCTCTCCTCATCTTCC	0.418													0	0	0	1	0	17	59										T	3765738	C	T	3765738	3	4	65	1	0	0	0	0	1	0	0	0	3227	864	30	1	410	1	CENPB	20	3765738	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	663703	3765738	59259782	1335	20368										
TMX4	56255	broad.mit.edu	37	chr20	7964486	7964486	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagtggcacatagaaacattCtgatattaccaccaagacct	6	10	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:7964486C>G	uc002wmx.1	-	7	767	c.634G>C	c.(634-636)GAA>CAA	p.E212Q		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	212					cell redox homeostasis|electron transport chain|transport	integral to membrane					0						TAGAAACATTCTGATATTACC	0.388													0	0	0	1	0	12	43										G	7964486	C	G	7964486	3	3	65	1	0	0	0	0	1	0	0	0	16266	922	32	1	423	1	TMX4	20	7964486	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4198748	7964486	55061034	1336	20369										
NKX2-2	4821	broad.mit.edu	37	chr20	21492922	21492922	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtgttcgcgctcgggcgccGacaggtaccgctgctgccga	16	14	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:21492922G>T	uc002wsi.2	-	2	818	c.461C>A	c.(460-462)TCG>TAG	p.S154*		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	154	Homeobox.				brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						CTCGGGCGCCGACAGGTACCG	0.672													1	0	1.12685e-05	1	1.14925e-05	9	33										T	21492922	G	T	21492922	4	4	65	1	0	0	0	0	0	1	0	0	10450	1059	37	3	364	3	NKX2-2	20	21492922	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	13528436	21492922	41532598	1337	20370										
FOXA2	3170	broad.mit.edu	37	chr20	22562719	22562719	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctgctgctccgaggacatGaggttgttgatggagaacgg	16	7	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:22562719G>A	uc002wsn.2	-	3	1333	c.1143C>T	c.(1141-1143)CTC>CTT	p.L381L	FOXA2_uc002wsm.2_Silent_p.L387L	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	381	Transactivation domain 2 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					CCGAGGACATGAGGTTGTTGA	0.552													0	0	0	1	0	13	33										A	22562719	G	A	22562719	2	1	65	1	0	0	0	0	0	0	0	1	5990	1277	45	1		1	FOXA2	20	22562719	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1069797	22562719	40462801	1338	20371										
ASXL1	171023	broad.mit.edu	37	chr20	31022245	31022245	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttttttgcagattcaactttCacgtatcaaaccaccctggg	6	11	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:31022245C>G	uc002wxs.2	+	12	2156	c.1730C>G	c.(1729-1731)TCA>TGA	p.S577*	ASXL1_uc010geb.2_Nonsense_Mutation_p.S468*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	577					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						ATTCAACTTTCACGTATCAAA	0.473			F|N|Mis		MDS|CMML								0	0	0	1	0	18	103										G	31022245	C	G	31022245	4	3	65	1	0	0	0	0	0	1	0	0	1066	838	29	1	1786	1	ASXL1	20	31022245	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8459526	31022245	32003275	1339	20372										
GGT7	2686	broad.mit.edu	37	chr20	33439105	33439105	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtaggttccacagagcccctCcgcgggtcggaccactgtgg	14	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:33439105C>T	uc002xay.2	-	13	1697	c.1654G>A	c.(1654-1656)GAG>AAG	p.E552K	GGT7_uc010gex.2_RNA|GGT7_uc002xaz.1_Missense_Mutation_p.E569K	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	552	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						CAGAGCCCCTCCGCGGGTCGG	0.622													0	0	0	1	0	28	67										T	33439105	C	T	33439105	3	4	65	1	0	0	0	0	1	0	0	0	6364	864	30	1	346	1	GGT7	20	33439105	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2416860	33439105	29586415	1340	20373										
GGT7	2686	broad.mit.edu	37	chr20	33440073	33440073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgccaaagggctggttcaggGagctgggggccgaggtgggg	22	7	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:33440073G>A	uc002xay.2	-	12	1515	c.1472C>T	c.(1471-1473)TCC>TTC	p.S491F	GGT7_uc010gex.2_5'Flank|GGT7_uc002xaz.1_Missense_Mutation_p.S508F	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	491	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						CTGGTTCAGGGAGCTGGGGGC	0.637													0	0	0	1	0	18	46										A	33440073	G	A	33440073	3	1	65	1	0	0	0	0	1	0	0	0	6364	1174	41	1	532	1	GGT7	20	33440073	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	968	33440073	29585447	1341	20374										
FAM83C	128876	broad.mit.edu	37	chr20	33874440	33874440	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcagccgtttctcatccctGaccaggtcactgttaccacc	7	16	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:33874440G>C	uc010zux.1	-	4	2260	c.2142C>G	c.(2140-2142)GTC>GTG	p.V714V	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Silent_p.V369V	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	714										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TCTCATCCCTGACCAGGTCAC	0.552													0	0	0	1	0	39	102										C	33874440	G	C	33874440	2	2	65	1	0	0	0	0	0	0	0	1	5635	1277	45	1		1	FAM83C	20	33874440	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	434367	33874440	29151080	1342	20375										
CEP250	11190	broad.mit.edu	37	chr20	34065849	34065849	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcagctgcagaaagctgagGaggctggggctgagctgcag	17	9	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:34065849G>T	uc002xcm.2	+	18	2688	c.2017G>T	c.(2017-2019)GAG>TAG	p.E673*	CEP250_uc010zve.1_Nonsense_Mutation_p.E41*|CEP250_uc010zvd.1_RNA	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	673	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAAAGCTGAGGAGGCTGGGGC	0.527													1	0	0.000602214	1	0.000609414	5	33										T	34065849	G	T	34065849	4	4	65	1	0	0	0	0	0	1	0	0	3252	1175	41	3	2071	3	CEP250	20	34065849	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	191409	34065849	28959671	1343	20376										
CEP250	11190	broad.mit.edu	37	chr20	34065861	34065861	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagctgaggaggctggggctGagctgcaggcagatctcagg	18	8	1	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:34065861G>C	uc002xcm.2	+	18	2700	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	CEP250_uc010zve.1_Missense_Mutation_p.E45Q|CEP250_uc010zvd.1_RNA	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	677	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGCTGGGGCTGAGCTGCAGGC	0.532													0	0	0	1	0	5	40										C	34065861	G	C	34065861	3	2	65	1	0	0	0	0	1	0	0	0	3252	1291	45	1	2083	1	CEP250	20	34065861	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	12	34065861	28959659	1344	20377										
NFS1	9054	broad.mit.edu	37	chr20	34261595	34261595	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aagagggctccagggatgcaGaggtgcaggcactgaggaga	18	7	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:34261595G>C	uc002xdw.1	-	11	1212	c.1148C>G	c.(1147-1149)TCT>TGT	p.S383C	CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_RNA|CPNE1_uc002xdp.1_RNA|NFS1_uc002xdt.1_Missense_Mutation_p.S323C|NFS1_uc002xdu.1_Missense_Mutation_p.S323C|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_Missense_Mutation_p.S181C|NFS1_uc010zvl.1_Missense_Mutation_p.S332C	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	383					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CAGGGATGCAGAGGTGCAGGC	0.493													0	0	0	1	0	17	57										C	34261595	G	C	34261595	3	2	65	1	0	0	0	0	1	0	0	0	10385	942	33	1	237	1	NFS1	20	34261595	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	195734	34261595	28763925	1345	20378										
NFS1	9054	broad.mit.edu	37	chr20	34262520	34262520	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcagccgctctgacaactttGagattcgcttgtggtcatac	9	11	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:34262520G>C	uc002xdw.1	-	9	1032	c.968C>G	c.(967-969)TCA>TGA	p.S323*	CPNE1_uc002xdn.1_5'Flank|CPNE1_uc002xdo.1_5'Flank|CPNE1_uc002xdp.1_RNA|NFS1_uc002xdt.1_Nonsense_Mutation_p.S263*|NFS1_uc002xdu.1_Nonsense_Mutation_p.S263*|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_Nonsense_Mutation_p.S121*|NFS1_uc010zvl.1_Nonsense_Mutation_p.S272*	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	323					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TGACAACTTTGAGATTCGCTT	0.463													0	0	0	1	0	13	60										C	34262520	G	C	34262520	4	2	65	1	0	0	0	0	0	1	0	0	10385	1294	45	1	425	1	NFS1	20	34262520	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	925	34262520	28763000	1346	20379										
MANBAL	63905	broad.mit.edu	37	chr20	35929739	35929739	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggagaacctgctacggtacGgactcttcctgggagccatc	12	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:35929739G>A	uc002xgu.2	+	3	285	c.73G>A	c.(73-75)GGA>AGA	p.G25R	MANBAL_uc002xgv.2_Missense_Mutation_p.G25R|MANBAL_uc002xgw.2_RNA|MANBAL_uc010gfx.2_RNA|MANBAL_uc010gfy.2_RNA	NM_022077	NP_071360	Q9NQG1	MANBL_HUMAN	mannosidase, beta A, lysosomal-like	25	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(115;0.00878)				GCTACGGTACGGACTCTTCCT	0.597													0	0	0	1	0	24	90										A	35929739	G	A	35929739	3	1	65	1	0	0	0	0	1	0	0	0	9220	1117	39	2	75	2	MANBAL	20	35929739	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1667219	35929739	27095781	1347	20380										
SLC32A1	140679	broad.mit.edu	37	chr20	37357157	37357157	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcgcctgctctggcgcaagCtgctgtggcaccaagtcttc	12	14	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:37357157C>G	uc002xjc.2	+	2	1716	c.1453C>G	c.(1453-1455)CTG>GTG	p.L485V		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	485	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CTGGCGCAAGCTGCTGTGGCA	0.652													0	0	0	1	0	16	42										G	37357157	C	G	37357157	3	3	65	1	0	0	0	0	1	0	0	0	14565	796	28	4	1459	4	SLC32A1	20	37357157	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1427418	37357157	25668363	1348	20381										
SFRS6	6431	broad.mit.edu	37	chr20	42088739	42088739	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggaacgaacaaatgagggtGtaattgagtttcgctcctac	11	7	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:42088739G>T	uc010zwg.1	+	4	618	c.448G>T	c.(448-450)GTA>TTA	p.V150L	SFRS6_uc002xki.2_Missense_Mutation_p.V21L|SFRS6_uc002xkk.2_Missense_Mutation_p.V150L	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	150	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AAATGAGGGTGTAATTGAGTT	0.428													1	0	2.27111e-07	1	2.34737e-07	13	61										T	42088739	G	T	42088739	3	4	65	1	0	0	0	0	1	0	0	0	14181	1377	48	4	462	4	SFRS6	20	42088739	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4731582	42088739	20936781	1349	20382										
SFRS6	6431	broad.mit.edu	37	chr20	42088812	42088812	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggcacagaaataaatggcaGaaatattaggcttattgaag	10	4	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:42088812G>C	uc010zwg.1	+	4	691	c.521G>C	c.(520-522)AGA>ACA	p.R174T	SFRS6_uc002xki.2_Missense_Mutation_p.R45T|SFRS6_uc002xkk.2_Missense_Mutation_p.R174T	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	174	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATAAATGGCAGAAATATTAGG	0.453													0	0	0	1	0	13	44										C	42088812	G	C	42088812	3	2	65	1	0	0	0	0	1	0	0	0	14181	942	33	1	535	1	SFRS6	20	42088812	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	73	42088812	20936708	1350	20383										
TP53TG5	27296	broad.mit.edu	37	chr20	44003758	44003758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcttgacccaacgcagggtgGaggatctgcacatcaccctg	12	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:44003758G>A	uc002xny.2	-	4	770	c.689C>T	c.(688-690)TCC>TTC	p.S230F	SYS1_uc002xnw.1_3'UTR|SYS1-DBNDD2_uc002xnx.2_Intron	NM_014477	NP_055292	Q9Y2B4	T53G5_HUMAN	TP53-target gene 5 protein	230					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)	1						ACGCAGGGTGGAGGATCTGCA	0.597													0	0	0	1	0	28	79										A	44003758	G	A	44003758	3	1	65	1	0	0	0	0	1	0	0	0	16388	1174	41	1	191	1	TP53TG5	20	44003758	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1914946	44003758	19021762	1351	20384										
PCIF1	63935	broad.mit.edu	37	chr20	44573623	44573623	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccctggagtacgtcaaacgGatccgagagaagcaccttgc	11	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:44573623G>C	uc002xqs.2	+	11	1436	c.1122G>C	c.(1120-1122)CGG>CGC	p.R374R	PCIF1_uc002xqt.2_5'UTR|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	374						nucleus				skin(1)	1						ACGTCAAACGGATCCGAGAGA	0.572													0	0	0	1	0	7	36										C	44573623	G	C	44573623	2	2	65	1	0	0	0	0	0	0	0	1	11580	1161	41	1		1	PCIF1	20	44573623	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	569865	44573623	18451897	1352	20385										
PCIF1	63935	broad.mit.edu	37	chr20	44574946	44574946	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcgtcagcttcgagtgcttCgcctcacccctcaactgcta	9	16	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:44574946C>T	uc002xqs.2	+	14	1850	c.1536C>T	c.(1534-1536)TTC>TTT	p.F512F	PCIF1_uc002xqt.2_Silent_p.F92F|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	512						nucleus				skin(1)	1						TCGAGTGCTTCGCCTCACCCC	0.642													0	0	0	1	0	55	163										T	44574946	C	T	44574946	2	4	65	1	0	0	0	0	0	0	0	1	11580	883	31	1		1	PCIF1	20	44574946	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1323	44574946	18450574	1353	20386										
SLC12A5	57468	broad.mit.edu	37	chr20	44678355	44678355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccagctgaaggcggggaagGgcctgaccatcgtgggctct	16	12	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:44678355G>A	uc010zxl.1	+	17	2252	c.2176G>A	c.(2176-2178)GGC>AGC	p.G726S	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.G703S	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	726					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGCGGGGAAGGGCCTGACCAT	0.622													0	0	0	1	0	3	8										A	44678355	G	A	44678355	3	1	65	1	0	0	0	0	1	0	0	0	14386	1232	43	2	2298	2	SLC12A5	20	44678355	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	103409	44678355	18347165	1354	20387										
ZNF334	55713	broad.mit.edu	37	chr20	45130355	45130355	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tcattgcattcatatggtctCtcccatatagttctctgatg	6	10	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:45130355C>T	uc002xsc.2	-	5	1807	c.1623G>A	c.(1621-1623)GAG>GAA	p.E541E	ZNF334_uc002xsa.2_Silent_p.E564E|ZNF334_uc002xsb.2_Silent_p.E503E|ZNF334_uc002xsd.2_Silent_p.E503E|ZNF334_uc010ghl.2_Silent_p.E540E	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CATATGGTCTCTCCCATATAG	0.448													0	0	0	1	0	40	149										T	45130355	C	T	45130355	2	4	65	1	0	0	0	0	0	0	0	1	17848	912	32	1		1	ZNF334	20	45130355	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	452000	45130355	17895165	1355	20388										
CSE1L	1434	broad.mit.edu	37	chr20	47706100	47706100	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	attccatacgtctttcaagtGatgtctttgcttctggaaac	7	9	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:47706100G>A	uc002xty.2	+	19	2132	c.1998G>A	c.(1996-1998)GTG>GTA	p.V666V	CSE1L_uc010zyg.1_Silent_p.V449V|CSE1L_uc010ghx.2_Silent_p.V610V|CSE1L_uc010ghy.2_Silent_p.V287V|CSE1L_uc010zyh.1_Silent_p.V315V	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	666					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TCTTTCAAGTGATGTCTTTGC	0.413													0	0	0	1	0	14	67										A	47706100	G	A	47706100	2	1	65	1	0	0	0	0	0	0	0	1	3930	1277	45	1		1	CSE1L	20	47706100	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2575745	47706100	15319420	1356	20389										
SALL4	57167	broad.mit.edu	37	chr20	50418832	50418832	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	actcacccagctcccccgccGcgggcgccgctggggccgca	13	21	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:50418832G>A	uc002xwh.3	-	1	217	c.116C>T	c.(115-117)GCG>GTG	p.A39V	SALL4_uc010gii.2_Missense_Mutation_p.A39V|SALL4_uc002xwi.3_Missense_Mutation_p.A39V	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	39					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTcccccgccgcgggcgccgc	0.612													0	0	0	1	0	4	19										A	50418832	G	A	50418832	3	1	65	1	0	0	0	0	1	0	0	0	13813	1087	38	2	3061	2	SALL4	20	50418832	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2712732	50418832	12606688	1357	20390										
STX16	8675	broad.mit.edu	37	chr20	57245657	57245657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acgataacactctttaccatCgggtacgtgaacgggctgca	10	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:57245657C>T	uc002xzi.2	+	6	1381	c.646C>T	c.(646-648)CGG>TGG	p.R216W	STX16_uc010zzq.1_Missense_Mutation_p.R30W|STX16_uc002xzk.2_Missense_Mutation_p.R199W|STX16_uc002xzm.2_Missense_Mutation_p.R212W|STX16_uc002xzj.2_Missense_Mutation_p.R195W|STX16_uc002xzl.2_Missense_Mutation_p.R30W	NM_001001433	NP_001001433	O14662	STX16_HUMAN	syntaxin 16 isoform a	216	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			ovary(1)	1	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			TCTTTACCATCGGGTACGTGA	0.473													0	0	0	1	0	20	63										T	57245657	C	T	57245657	3	4	65	1	0	0	0	0	1	0	0	0	15338	875	31	1	668	1	STX16	20	57245657	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6826825	57245657	5779863	1358	20391										
PHACTR3	116154	broad.mit.edu	37	chr20	58330240	58330240	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gctacatttccttgtagatgCtgaaagcaaaacttgcaacc	7	10	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:58330240C>T	uc002yau.2	+	4	829	c.362C>T	c.(361-363)GCT>GTT	p.A121V	PHACTR3_uc002yat.2_Missense_Mutation_p.A118V|PHACTR3_uc010zzw.1_Missense_Mutation_p.A80V|PHACTR3_uc002yav.2_Missense_Mutation_p.A80V|PHACTR3_uc002yaw.2_Missense_Mutation_p.A80V|PHACTR3_uc002yax.2_Missense_Mutation_p.A80V	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	121						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CTTGTAGATGCTGAAAGCAAA	0.537													0	0	0	1	0	13	43										T	58330240	C	T	58330240	3	4	65	1	0	0	0	0	1	0	0	0	11811	797	28	2	376	2	PHACTR3	20	58330240	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1084583	58330240	4695280	1359	20392										
DIDO1	11083	broad.mit.edu	37	chr20	61524224	61524224	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtgacaaattttgccacactCtgcatgttaataaatccttt	5	9	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:61524224C>G	uc002ydr.1	-	13	3456	c.3192G>C	c.(3190-3192)CAG>CAC	p.Q1064H	DIDO1_uc002yds.1_Missense_Mutation_p.Q1064H|DIDO1_uc002ydt.1_Missense_Mutation_p.Q1064H|DIDO1_uc002ydu.1_Missense_Mutation_p.Q1064H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1064					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TTGCCACACTCTGCATGTTAA	0.448													0	0	0	1	0	17	64										G	61524224	C	G	61524224	3	3	65	1	0	0	0	0	1	0	0	0	4522	912	32	1	3575	1	DIDO1	20	61524224	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3193984	61524224	1501296	1360	20393										
EEF1A2	1917	broad.mit.edu	37	chr20	62127331	62127331	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtcgatggtgatgccgcgctCacgctccgccttcagcttgt	12	14	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:62127331C>G	uc002yfd.1	-	2	303	c.202G>C	c.(202-204)GAG>CAG	p.E68Q	EEF1A2_uc002yfe.1_Missense_Mutation_p.E68Q|EEF1A2_uc010gkg.1_Missense_Mutation_p.E68Q	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	68						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			ATGCCGCGCTCACGCTCCGCC	0.612											OREG0026129	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	36	118										G	62127331	C	G	62127331	3	3	65	1	0	0	0	0	1	0	0	0	4924	835	29	1	1213	1	EEF1A2	20	62127331	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	603107	62127331	898189	1361	20394										
STMN3	50861	broad.mit.edu	37	chr20	62275251	62275251	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgacctcgaagctctggcctGaggcccgcttgtccagctgc	12	15	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr20:62275251G>C	uc002yfr.1	-	3	231	c.149C>G	c.(148-150)TCA>TGA	p.S50*	STMN3_uc011abb.1_Nonsense_Mutation_p.S50*	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	50					cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			GCTCTGGCCTGAGGCCCGCTT	0.627													0	0	0	1	0	31	110										C	62275251	G	C	62275251	4	2	65	1	0	0	0	0	0	1	0	0	15309	1294	45	1	405	1	STMN3	20	62275251	Nonsense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	147920	62275251	750269	1362	20395										
CLDN17	26285	broad.mit.edu	37	chr21	31538639	31538639	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggacctgcttcatgccacaGatgccaataagcagggcgat	11	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:31538639G>C	uc011acv.1	-	1	297	c.297C>G	c.(295-297)ATC>ATG	p.I99M		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	99	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						TCATGCCACAGATGCCAATAA	0.567													0	0	0	1	0	37	83										C	31538639	G	C	31538639	3	2	65	1	0	0	0	0	1	0	0	0	3478	932	33	1	381	1	CLDN17	21	31538639	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		31538639	16591256	1363	20396										
C21orf45	54069	broad.mit.edu	37	chr21	33651219	33651219	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggtggcggctcgagtcttcgGagagtctcttgcccaacagc	14	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:33651219G>C	uc002ypi.2	-	1	158	c.107C>G	c.(106-108)TCC>TGC	p.S36C	C21orf45_uc011adn.1_Missense_Mutation_p.S36C	NM_018944	NP_061817	Q9NYP9	MS18A_HUMAN	chromosome 21 open reading frame 45	36					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm					0						CGAGTCTTCGGAGAGTCTCTT	0.637													0	0	0	1	0	16	57										C	33651219	G	C	33651219	3	2	65	1	0	0	0	0	1	0	0	0	2126	1174	41	1	614	1	C21orf45	21	33651219	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2112580	33651219	14478676	1364	20397										
GCFC1	94104	broad.mit.edu	37	chr21	34133456	34133456	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagttactaaagcatcatCatcactcccctcaattccta	2	15	4	0	rs79555426	by1000genomes	TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:34133456C>G	uc002yqn.2	-	5	1079	c.889G>C	c.(889-891)GAT>CAT	p.D297H	GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D297H|GCFC1_uc002yqr.2_Missense_Mutation_p.D297H	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	297						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						AAAGCATCATCATCACTCCCC	0.423													0	0	0	1	0	60	194										G	34133456	C	G	34133456	3	3	65	1	0	0	0	0	1	0	0	0	6289	826	29	1	2038	1	GCFC1	21	34133456	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	482237	34133456	13996439	1365	20398										
KCNE2	9992	broad.mit.edu	37	chr21	35743045	35743045	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctaccaccagtacattgtaGaggactggcaggaaaagtac	10	10	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:35743045G>C	uc002ytt.1	+	2	408	c.268G>C	c.(268-270)GAG>CAG	p.E90Q		NM_172201	NP_751951	Q9Y6J6	KCNE2_HUMAN	potassium voltage-gated channel, Isk-related	90	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction	lysosome|voltage-gated potassium channel complex	voltage-gated potassium channel activity				0						GTACATTGTAGAGGACTGGCA	0.483													0	0	0	1	0	14	39										C	35743045	G	C	35743045	3	2	65	1	0	0	0	0	1	0	0	0	8023	943	33	1	270	1	KCNE2	21	35743045	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1609589	35743045	12386850	1366	20399										
DOPEY2	9980	broad.mit.edu	37	chr21	37617591	37617591	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggacggcccacggcgccccgGacagcagcgagcacaccgag	15	17	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:37617591G>C	uc002yvg.2	+	19	3392	c.3313G>C	c.(3313-3315)GAC>CAC	p.D1105H	DOPEY2_uc011aeb.1_Missense_Mutation_p.D1054H|DOPEY2_uc002yvh.2_5'UTR	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1105					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CGGCGCCCCGGACAGCAGCGA	0.647													0	0	0	1	0	21	104										C	37617591	G	C	37617591	3	2	65	1	0	0	0	0	1	0	0	0	4708	1174	41	1	3383	1	DOPEY2	21	37617591	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1874546	37617591	10512304	1367	20400			6	92		5	5	3251	N	G_C	1.804232e-05
DOPEY2	9980	broad.mit.edu	37	chr21	37617864	37617864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctgagtcgttctccagcgacGaggaggcggacttggagctc	15	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:37617864G>A	uc002yvg.2	+	19	3665	c.3586G>A	c.(3586-3588)GAG>AAG	p.E1196K	DOPEY2_uc011aeb.1_Missense_Mutation_p.E1145K|DOPEY2_uc002yvh.2_Missense_Mutation_p.E47K	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1196					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CTCCAGCGACGAGGAGGCGGA	0.617													0	0	0	1	0	22	71										A	37617864	G	A	37617864	3	1	65	1	0	0	0	0	1	0	0	0	4708	1059	37	1	3656	1	DOPEY2	21	37617864	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	273	37617864	10512031	1368	20401			6	92		5	5	3251	N	G_C	1.804232e-05
DOPEY2	9980	broad.mit.edu	37	chr21	37618604	37618604	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccgctgcagattgagctgctGaagctgctgcaggtgctgat	14	10	0	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:37618604G>A	uc002yvg.2	+	19	4405	c.4326G>A	c.(4324-4326)CTG>CTA	p.L1442L	DOPEY2_uc011aeb.1_Silent_p.L1391L|DOPEY2_uc002yvh.2_Silent_p.L293L	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1442					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TTGAGCTGCTGAAGCTGCTGC	0.612													0	0	0	1	0	16	43										A	37618604	G	A	37618604	2	1	65	1	0	0	0	0	0	0	0	1	4708	1277	45	1		1	DOPEY2	21	37618604	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	740	37618604	10511291	1369	20402			6	92		5	5	3251	N	G_C	1.804232e-05
DOPEY2	9980	broad.mit.edu	37	chr21	37618697	37618697	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gacctgtcccgggagtggcaGagagccctgaacttccagca	13	13	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:37618697G>C	uc002yvg.2	+	19	4498	c.4419G>C	c.(4417-4419)CAG>CAC	p.Q1473H	DOPEY2_uc011aeb.1_Missense_Mutation_p.Q1422H|DOPEY2_uc002yvh.2_Missense_Mutation_p.Q324H	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1473					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GGGAGTGGCAGAGAGCCCTGA	0.647													0	0	0	1	0	8	33										C	37618697	G	C	37618697	3	2	65	1	0	0	0	0	1	0	0	0	4708	933	33	1	4489	1	DOPEY2	21	37618697	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	93	37618697	10511198	1370	20403			6	92		5	5	3251	N	G_C	1.804232e-05
DOPEY2	9980	broad.mit.edu	37	chr21	37620841	37620841	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggggccacgaagggatcctCttccgtttactttaaaacca	9	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:37620841C>G	uc002yvg.2	+	21	5052	c.4973C>G	c.(4972-4974)TCT>TGT	p.S1658C	DOPEY2_uc011aeb.1_Missense_Mutation_p.S1607C|DOPEY2_uc002yvh.2_Missense_Mutation_p.S509C	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1658					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						AAGGGATCCTCTTCCGTTTAC	0.438													0	0	0	1	0	12	54										G	37620841	C	G	37620841	3	3	65	1	0	0	0	0	1	0	0	0	4708	913	32	1	5051	1	DOPEY2	21	37620841	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2144	37620841	10509054	1371	20404			6	92		5	5	3251	N	G_C	1.804232e-05
MORC3	23515	broad.mit.edu	37	chr21	37717293	37717293	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgtatcacagaaatagactCatcaaagcttatgaaaaagt	6	6	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:37717293C>T	uc002yvi.2	+	8	1045	c.969C>T	c.(967-969)CTC>CTT	p.L323L		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	323					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GAAATAGACTCATCAAAGCTT	0.279													0	0	0	1	0	9	26										T	37717293	C	T	37717293	2	4	65	1	0	0	0	0	0	0	0	1	9703	813	29	1		1	MORC3	21	37717293	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	96452	37717293	10412602	1372	20405										
DSCAM	1826	broad.mit.edu	37	chr21	41561016	41561016	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacctccttggtggacacaaGataacgggccatctcagggt	11	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:41561016G>C	uc002yyq.1	-	12	2958	c.2506C>G	c.(2506-2508)CTT>GTT	p.L836V	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	836	Ig-like C2-type 9.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTGGACACAAGATAACGGGCC	0.473													0	0	0	1	0	39	113										C	41561016	G	C	41561016	3	2	65	1	0	0	0	0	1	0	0	0	4768	942	33	1	3620	1	DSCAM	21	41561016	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	3843723	41561016	6568879	1373	20406										
TMPRSS2	7113	broad.mit.edu	37	chr21	42845282	42845282	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtgggcggctgtcacgatcCactcgggggtgatgatggag	18	8	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:42845282C>T	uc002yzj.2	-	9	1003	c.869G>A	c.(868-870)TGG>TAG	p.W290*	TMPRSS2_uc010gor.2_Nonsense_Mutation_p.W327*|TMPRSS2_uc010gos.1_Nonsense_Mutation_p.W290*	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	290	Peptidase S1.|Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				TGTCACGATCCACTCGGGGGT	0.672			T	ERG|ETV1|ETV4|ETV5	prostate 								0	0	0	1	0	10	24										T	42845282	C	T	42845282	4	4	65	1	0	0	0	0	0	1	0	0	16244	595	21	2	633	2	TMPRSS2	21	42845282	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1284266	42845282	5284613	1374	20407										
PDE9A	5152	broad.mit.edu	37	chr21	44192610	44192610	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaagtccagagagagaagcaGagatgtgaaaaacagtgaag	14	4	0	5			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:44192610G>C	uc002zbm.2	+	19	1811	c.1748G>C	c.(1747-1749)AGA>ACA	p.R583T	PDE9A_uc002zbn.2_Missense_Mutation_p.R456T|PDE9A_uc002zbo.2_Missense_Mutation_p.R530T|PDE9A_uc002zbp.2_Missense_Mutation_p.R376T|PDE9A_uc002zbq.2_Missense_Mutation_p.R481T|PDE9A_uc002zbs.2_Missense_Mutation_p.R376T|PDE9A_uc002zbr.2_Missense_Mutation_p.R376T|PDE9A_uc002zbt.2_Missense_Mutation_p.R455T|PDE9A_uc002zbu.2_Missense_Mutation_p.R449T|PDE9A_uc002zbv.2_Missense_Mutation_p.R423T|PDE9A_uc002zbw.2_Missense_Mutation_p.R366T|PDE9A_uc002zbx.2_Missense_Mutation_p.R523T|PDE9A_uc002zby.2_Missense_Mutation_p.R366T|PDE9A_uc002zbz.2_Missense_Mutation_p.R475T|PDE9A_uc002zca.2_Missense_Mutation_p.R542T|PDE9A_uc002zcb.2_Missense_Mutation_p.R557T|PDE9A_uc002zcc.2_Missense_Mutation_p.R482T|PDE9A_uc002zcd.2_Missense_Mutation_p.R497T|PDE9A_uc002zce.2_Missense_Mutation_p.R516T|PDE9A_uc002zcf.2_Missense_Mutation_p.R376T|PDE9A_uc002zcg.2_Missense_Mutation_p.R376T|PDE9A_uc002zch.2_Missense_Mutation_p.R366T	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	583					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						GAGAGAAGCAGAGATGTGAAA	0.498													0	0	0	1	0	6	15										C	44192610	G	C	44192610	3	2	65	1	0	0	0	0	1	0	0	0	11655	942	33	1	1902	1	PDE9A	21	44192610	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1347328	44192610	3937285	1375	20408										
PWP2	5822	broad.mit.edu	37	chr21	45548494	45548494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcatccagcggcacctggacGacctgtcgaaactgtacgtg	12	13	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:45548494G>A	uc002zeb.2	+	20	2662	c.2572G>A	c.(2572-2574)GAC>AAC	p.D858N		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	858						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		GCACCTGGACGACCTGTCGAA	0.632													0	0	0	1	0	8	36										A	45548494	G	A	45548494	3	1	65	1	0	0	0	0	1	0	0	0	12844	1058	37	1	2650	1	PWP2	21	45548494	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1355884	45548494	2581401	1376	20409										
KRTAP10-9	386676	broad.mit.edu	37	chr21	46047228	46047228	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccctgcctgaccctggtctGcaccccagtgagccgtgtat	10	17	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:46047228G>A	uc002zfp.3	+	1	189	c.140G>A	c.(139-141)TGC>TAC	p.C47Y	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	47	25 X 5 AA repeats of C-C-X(3).					keratin filament					0						ACCCTGGTCTGCACCCCAGTG	0.701													0	0	0	1	0	36	146										A	46047228	G	A	46047228	3	1	65	1	0	0	0	0	1	0	0	0	8516	1319	46	2	142	2	KRTAP10-9	21	46047228	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	498734	46047228	2082667	1377	20410										
ADARB1	104	broad.mit.edu	37	chr21	46596309	46596309	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttaccaccattcccacccccGagtgggaagaatcccgtgat	8	15	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:46596309G>A	uc002zgy.2	+	4	1128	c.693G>A	c.(691-693)CCG>CCA	p.P231P	ADARB1_uc002zgr.2_Silent_p.P231P|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Silent_p.P231P|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Silent_p.P231P|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Silent_p.P280P	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	231	DRBM 2.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		TCCCACCCCCGAGTGGGAAGA	0.597													0	0	0	1	0	21	84										A	46596309	G	A	46596309	2	1	65	1	0	0	0	0	0	0	0	1	282	1045	37	1		1	ADARB1	21	46596309	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	549081	46596309	1533586	1378	20411										
PCNT	5116	broad.mit.edu	37	chr21	47851626	47851626	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tccagaaggaccttgcggctGagaagagccgcaccctggag	14	12	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr21:47851626G>C	uc002zji.3	+	38	8355	c.8248G>C	c.(8248-8250)GAG>CAG	p.E2750Q	PCNT_uc002zjj.2_Missense_Mutation_p.E2632Q	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2750	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CCTTGCGGCTGAGAAGAGCCG	0.647													0	0	0	1	0	7	36										C	47851626	G	C	47851626	3	2	65	1	0	0	0	0	1	0	0	0	11590	1291	45	1	8398	1	PCNT	21	47851626	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1255317	47851626	278269	1379	20412										
SLC7A4	6545	broad.mit.edu	37	chr22	21384215	21384215	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgctccagggctgtacccatCcaagaagcccaggtagggcc	12	14	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:21384215C>T	uc002zud.2	-	3	1476	c.1408G>A	c.(1408-1410)GAT>AAT	p.D470N	SLC7A4_uc002zue.2_Missense_Mutation_p.D470N	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	470					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CTGTACCCATCCAAGAAGCCC	0.612													0	0	0	1	0	16	48										T	21384215	C	T	21384215	3	4	65	1	0	0	0	0	1	0	0	0	14699	855	30	1	511	1	SLC7A4	22	21384215	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08		21384215	29920351	1380	20413										
MYO18B	84700	broad.mit.edu	37	chr22	26176157	26176157	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	caggccgcatcacagctgctCagctccaggtgaggcctctc	11	16	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:26176157C>G	uc003abz.1	+	9	2453	c.2203C>G	c.(2203-2205)CAG>GAG	p.Q735E	MYO18B_uc003aca.1_Missense_Mutation_p.Q616E|MYO18B_uc010guy.1_Missense_Mutation_p.Q616E|MYO18B_uc010guz.1_Missense_Mutation_p.Q616E|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_Missense_Mutation_p.Q248E	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	735	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CACAGCTGCTCAGCTCCAGGT	0.657													0	0	0	1	0	6	22										G	26176157	C	G	26176157	3	3	65	1	0	0	0	0	1	0	0	0	10066	827	29	1	2233	1	MYO18B	22	26176157	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4791942	26176157	25128409	1381	20414										
GAS2L1	10634	broad.mit.edu	37	chr22	29707904	29707904	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcaccccggctttcccgggtCtccagccccagtccagagtt	10	18	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:29707904C>T	uc003afa.1	+	7	1663	c.1464C>T	c.(1462-1464)GTC>GTT	p.V488V	GAS2L1_uc010gvm.1_Intron|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Silent_p.V488V|GAS2L1_uc003afd.1_Missense_Mutation_p.S488F|GAS2L1_uc003afe.1_Missense_Mutation_p.S488F	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	488					cell cycle arrest	cytoplasm|cytoskeleton					0						TTTCCCGGGTCTCCAGCCCCA	0.716													0	0	0	1	0	19	50										T	29707904	C	T	29707904	2	4	65	1	0	0	0	0	0	0	0	1	6246	913	32	1		1	GAS2L1	22	29707904	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3531747	29707904	21596662	1382	20415										
MTP18	51537	broad.mit.edu	37	chr22	30822740	30822740	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgggcgaggctttccgctctCttgtgccagcggcggtggtg	17	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:30822740C>T	uc003ahw.1	+	2	251	c.103C>T	c.(103-105)CTT>TTT	p.L35F	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Missense_Mutation_p.L197F|MTP18_uc010gvy.1_Intron|MTP18_uc003ahx.1_Missense_Mutation_p.L35F	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	35	Helical; (Potential).				apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						TTTCCGCTCTCTTGTGCCAGC	0.542											OREG0026460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	18	58										T	30822740	C	T	30822740	3	4	65	1	0	0	0	0	1	0	0	0	9955	913	32	1	109	1	MTP18	22	30822740	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1114836	30822740	20481826	1383	20416										
OSBP2	23762	broad.mit.edu	37	chr22	31302219	31302219	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctacacgccactgtggtttGagaagaggctggatccgctg	13	11	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:31302219G>C	uc003aiy.1	+	14	2748	c.2644G>C	c.(2644-2646)GAG>CAG	p.E882Q	OSBP2_uc011ala.1_Missense_Mutation_p.E716Q|OSBP2_uc010gwc.1_Missense_Mutation_p.E709Q|OSBP2_uc011alb.1_Nonstop_Mutation_p.*875S|OSBP2_uc003aiz.1_Missense_Mutation_p.E881Q|OSBP2_uc003aja.1_Missense_Mutation_p.E515Q|OSBP2_uc011alc.1_Missense_Mutation_p.E625Q|OSBP2_uc003ajb.2_Missense_Mutation_p.E427Q|OSBP2_uc011ald.1_Missense_Mutation_p.E426Q|OSBP2_uc010gwd.1_Nonstop_Mutation_p.*365S	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	882					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						ACTGTGGTTTGAGAAGAGGCT	0.627													0	0	0	1	0	34	81										C	31302219	G	C	31302219	3	2	65	1	0	0	0	0	1	0	0	0	11274	1291	45	1	2698	1	OSBP2	22	31302219	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	479479	31302219	20002347	1384	20417										
MYH9	4627	broad.mit.edu	37	chr22	36718556	36718557	+	Missense_Mutation	DNP	TC	TC	CT													0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggcctgcagcagctgccgcTccagctcgccctgcaaggaa							TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:36718556_36718557TC>CT	uc003apg.2	-	6	853_854	c.622_623GA>AG	c.(622-624)GAG>AGG	p.E208R	MYH9_uc003aph.1_Missense_Mutation_p.E72R	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	208	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CAGCTGCCGCTCCAGCTCGCCC	0.683			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	1	0	37	59										CT	36718557	TC	CT	36718556	3	2	65	1	0	0	0	0	1	0	0	0	10042	1551	54	5	5403	5	MYH9	22	36718556	Missense_Mutation	DNP	TC	TCGA-DK-A3WW-01A-22D-A23M-08	5416337	36718556	14586010	1385	20418										
EP300	2033	broad.mit.edu	37	chr22	41513766	41513766	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	acttactgactgagcctcttCagcagggctctccccagatg	9	14	3	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:41513766C>T	uc003azl.3	+	2	1065	c.670C>T	c.(670-672)CAG>TAG	p.Q224*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	224					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGAGCCTCTTCAGCAGGGCTC	0.532			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	1	0	16	34										T	41513766	C	T	41513766	4	4	65	1	0	0	0	0	0	1	0	0	5148	827	29	1	676	1	EP300	22	41513766	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4795210	41513766	9790800	1386	20419										
EP300	2033	broad.mit.edu	37	chr22	41573148	41573148	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctgcctaaacatcaagcaGaagctccggcagcaacagct	8	13	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:41573148G>T	uc003azl.3	+	31	5828	c.5433G>T	c.(5431-5433)CAG>CAT	p.Q1811H		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1811	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ACATCAAGCAGAAGCTCCGGC	0.597			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				1	0	1.55811e-20	1	1.65592e-20	31	90										T	41573148	G	T	41573148	3	4	65	1	0	0	0	0	1	0	0	0	5148	933	33	3	5555	3	EP300	22	41573148	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	59382	41573148	9731418	1387	20420										
NAGA	4668	broad.mit.edu	37	chr22	42463781	42463781	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cggctcacgtagtcagccagGaaaggaatgccatgagggaa	14	9	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:42463781G>A	uc003bbx.2	-	4	449	c.312C>T	c.(310-312)TTC>TTT	p.F104F	NAGA_uc003bby.2_Silent_p.F104F|NAGA_uc003bbw.3_Silent_p.F104F	NM_000262	NP_000253	P17050	NAGAB_HUMAN	alpha-N-acetylgalactosaminidase precursor	104					glycoside catabolic process|glycosylceramide catabolic process|oligosaccharide metabolic process	lysosome	alpha-galactosidase activity|alpha-N-acetylgalactosaminidase activity|cation binding|protein homodimerization activity			central_nervous_system(1)	1						AGTCAGCCAGGAAAGGAATGC	0.582													0	0	0	1	0	30	95										A	42463781	G	A	42463781	2	1	65	1	0	0	0	0	0	0	0	1	10141	1165	41	1		1	NAGA	22	42463781	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	890633	42463781	8840785	1388	20421										
TCF20	6942	broad.mit.edu	37	chr22	42606970	42606970	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aactgtttctgcatgtgtctCtgtcttcactttgtcatcca	6	11	5	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:42606970C>G	uc003bcj.1	-	1	4476	c.4342G>C	c.(4342-4344)GAG>CAG	p.E1448Q	TCF20_uc003bck.1_Missense_Mutation_p.E1448Q|TCF20_uc003bnt.2_Missense_Mutation_p.E1448Q	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GCATGTGTCTCTGTCTTCACT	0.527													0	0	0	1	0	52	158										G	42606970	C	G	42606970	3	3	65	1	0	0	0	0	1	0	0	0	15687	922	32	1	1578	1	TCF20	22	42606970	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	143189	42606970	8697596	1389	20422										
ARFGAP3	26286	broad.mit.edu	37	chr22	43204836	43204836	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gccttgacattgccaaacttCttctgggcctcatctgtatt	7	12	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:43204836C>A	uc003bdd.2	-	13	1477	c.1257G>T	c.(1255-1257)AAG>AAT	p.K419N	ARFGAP3_uc010gzf.2_Missense_Mutation_p.K375N	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	419					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						TGCCAAACTTCTTCTGGGCCT	0.423													1	0	4.16155e-14	1	4.3788e-14	41	109										A	43204836	C	A	43204836	3	1	65	1	0	0	0	0	1	0	0	0	851	912	32	3	309	3	ARFGAP3	22	43204836	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	597866	43204836	8099730	1390	20423										
PNPLA3	80339	broad.mit.edu	37	chr22	44342253	44342253	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cccagtttttcactagagaaGagtctgtgagtcacttgagg	11	8	3	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:44342253G>A	uc003bei.1	+	9	1610	c.1437G>A	c.(1435-1437)AAG>AAA	p.K479K	PNPLA3_uc010gzm.1_Intron	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	479	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				CACTAGAGAAGAGTCTGTGAG	0.512											OREG0026623	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	29	96										A	44342253	G	A	44342253	2	1	65	1	0	0	0	0	0	0	0	1	12166	933	33	1		1	PNPLA3	22	44342253	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1137417	44342253	6962313	1391	20424										
PARVB	29780	broad.mit.edu	37	chr22	44395417	44395417	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttcattcctacctgcagcagGaggctggagctgagacgtgg	14	10	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:44395417G>T	uc003bem.2	+	2	123	c.75G>T	c.(73-75)AGG>AGT	p.R25S		NM_001003828	NP_001003828	Q9HBI1	PARVB_HUMAN	parvin, beta isoform a	Error:Variant_position_missing_in_Q9HBI1_after_alignment					cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				cctgcagcaggaggctggagc	0.005													1	0	8.73648e-17	1	9.25007e-17	35	105										T	44395417	G	T	44395417	3	4	65	1	0	0	0	0	1	0	0	0	11469	1165	41	3	81	3	PARVB	22	44395417	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	53164	44395417	6909149	1392	20425										
TBC1D22A	25771	broad.mit.edu	37	chr22	47307990	47307990	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atttttgaaaggatcttgttCatatgggcgatccgccaccc	9	10	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:47307990C>T	uc003bib.2	+	8	1056	c.921C>T	c.(919-921)TTC>TTT	p.F307F	TBC1D22A_uc010haf.2_Silent_p.F277F|TBC1D22A_uc003bic.2_Silent_p.F248F|TBC1D22A_uc003bie.2_Silent_p.F229F|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Silent_p.F260F	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	307	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGATCTTGTTCATATGGGCGA	0.373													0	0	0	1	0	35	85										T	47307990	C	T	47307990	2	4	65	1	0	0	0	0	0	0	0	1	15608	825	29	1		1	TBC1D22A	22	47307990	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2912573	47307990	3996576	1393	20426										
ZBED4	9889	broad.mit.edu	37	chr22	50277808	50277808	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacgtgaggcgcgcacacccGaccgtgctcattcaggaaaa	11	14	2	1	rs141158718		TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:50277808G>A	uc003bix.2	+	2	968	c.498G>A	c.(496-498)CCG>CCA	p.P166P		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	166	BED-type 1.					cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCGCACACCCGACCGTGCTCA	0.557													0	0	0	1	0	21	72										A	50277808	G	A	50277808	2	1	65	1	0	0	0	0	0	0	0	1	17517	1045	37	1		1	ZBED4	22	50277808	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2969818	50277808	1026758	1394	20427										
FAM116B	414918	broad.mit.edu	37	chr22	50753332	50753332	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cacagtgtctgcatatgagtCagcacaggccggaagcacct	11	12	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:50753332C>G	uc011aru.1	-	11	849	c.777G>C	c.(775-777)CTG>CTC	p.L259L	FAM116B_uc011arv.1_Silent_p.L259L	NM_001001794	NP_001001794	Q8NEG7	F116B_HUMAN	family with sequence similarity 116, member B	259											0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCATATGAGTCAGCACAGGCC	0.672													0	0	0	1	0	12	36										G	50753332	C	G	50753332	2	3	65	1	0	0	0	0	0	0	0	1	5408	813	29	1		1	FAM116B	22	50753332	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	475524	50753332	551234	1395	20428										
ARSA	410	broad.mit.edu	37	chr22	51063878	51063878	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcagggtctgcagtggtatCactgtgggcagagcctgggg	19	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chr22:51063878C>T	uc003bnb.3	-	9	1472	c.1219G>A	c.(1219-1221)GAT>AAT	p.D407N	ARSA_uc003bna.3_Missense_Mutation_p.D323N|ARSA_uc003bnc.3_Missense_Mutation_p.D407N|ARSA_uc003bnd.3_Missense_Mutation_p.D407N|ARSA_uc003bmz.3_Missense_Mutation_p.D407N	NM_001085426	NP_001078895	P15289	ARSA_HUMAN	arylsulfatase A isoform a precursor	407			Missing (in MLD; late-infantile-onset).			lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			pancreas(1)|skin(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	GCAGTGGTATCACTGTGGGCA	0.642													0	0	0	1	0	85	71										T	51063878	C	T	51063878	3	4	65	1	0	0	0	0	1	0	0	0	987	826	29	1	308	1	ARSA	22	51063878	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	310546	51063878	240688	1396	20429										
CSF2RA	1438	broad.mit.edu	37	chrX	1419439	1419439	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctttccaagctctgagcccaGagcaaaacacagtgtgaaga	9	11	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:1419439G>C	uc010nct.2	+	11	1188	c.866G>C	c.(865-867)AGA>ACA	p.R289T	CSF2RA_uc011mhb.1_Missense_Mutation_p.R289T|CSF2RA_uc004cpq.2_Intron|CSF2RA_uc004cpn.2_Missense_Mutation_p.R289T|CSF2RA_uc004cpo.2_Missense_Mutation_p.R289T|CSF2RA_uc010ncu.2_Intron|CSF2RA_uc011mhc.1_Missense_Mutation_p.R156T|CSF2RA_uc004cpp.2_Missense_Mutation_p.R289T|CSF2RA_uc010ncv.2_Missense_Mutation_p.R289T|CSF2RA_uc004cpr.2_Missense_Mutation_p.R289T	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	289	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TCTGAGCCCAGAGCAAAACAC	0.448													0	0	0	1	0	29	101										C	1419439	G	C	1419439	3	2	65	1	0	0	0	0	1	0	0	0	3934	942	33	1	896	1	CSF2RA	23	1419439	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		1419439	153851121	1397	20430										
IL3RA	3563	broad.mit.edu	37	chrX	1499937	1499937	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tatctggtgatgcagagactCtttccccgcatccctcacat	7	14	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:1499937C>G	uc004cps.2	+	11	1351	c.1002C>G	c.(1000-1002)CTC>CTG	p.L334L	IL3RA_uc011mhd.1_Silent_p.L256L	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	334	Cytoplasmic (Potential).|Box 1 motif.					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGCAGAGACTCTTTCCCCGCA	0.537													0	0	0	1	0	95	279										G	1499937	C	G	1499937	2	3	65	1	0	0	0	0	0	0	0	1	7695	900	32	1		1	IL3RA	23	1499937	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	80498	1499937	153770623	1398	20431										
SFRS17A	8227	broad.mit.edu	37	chrX	1719909	1719909	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	aggagagcccggcccacccaGaggccgacggcgctcccaaa	13	17	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:1719909G>A	uc004cqa.2	+	5	1706	c.1510G>A	c.(1510-1512)GAG>AAG	p.E504K	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	504					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGCCCACCCAGAGGCCGACGG	0.721													0	0	0	1	0	7	32										A	1719909	G	A	1719909	3	1	65	1	0	0	0	0	1	0	0	0	14173	943	33	1	1524	1	SFRS17A	23	1719909	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	219972	1719909	153550651	1399	20432										
ZBED1	9189	broad.mit.edu	37	chrX	2406874	2406874	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agccggttcctcttggcgctGaccacgttggcggcggatcc	14	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:2406874G>A	uc004cqg.2	-	2	2088	c.1887C>T	c.(1885-1887)GTC>GTT	p.V629V	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Silent_p.V629V	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	629						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTTGGCGCTGACCACGTTGG	0.677													0	0	0	1	0	86	217										A	2406874	G	A	2406874	2	1	65	1	0	0	0	0	0	0	0	1	17514	1277	45	1		1	ZBED1	23	2406874	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	686965	2406874	152863686	1400	20433										
ARHGAP6	395	broad.mit.edu	37	chrX	11157176	11157176	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ctcgctcggctgcttggcctCcctggtccgtgggtgtctcc	13	16	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:11157176C>G	uc004cup.1	-	13	3605	c.2732G>C	c.(2731-2733)GGA>GCA	p.G911A	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cum.1_Missense_Mutation_p.G708A|ARHGAP6_uc004cun.1_Missense_Mutation_p.G731A	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	911					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TGCTTGGCCTCCCTGGTCCGT	0.716													0	0	0	1	0	18	6										G	11157176	C	G	11157176	3	3	65	1	0	0	0	0	1	0	0	0	887	855	30	1	196	1	ARHGAP6	23	11157176	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8750302	11157176	144113384	1401	20434										
ASB11	140456	broad.mit.edu	37	chrX	15311338	15311338	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gaggccaggtgcacctccaaCtgggccttggctccgaactc	12	15	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:15311338C>G	uc004cwp.1	-	4	474	c.474G>C	c.(472-474)CAG>CAC	p.Q158H	ASB11_uc004cwo.1_Missense_Mutation_p.Q137H|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.Q141H	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	158	ANK 3.				intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					GCACCTCCAACTGGGCCTTGG	0.552													0	0	0	1	0	58	65										G	15311338	C	G	15311338	3	3	65	1	0	0	0	0	1	0	0	0	1015	564	20	4	513	4	ASB11	23	15311338	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	4154162	15311338	139959222	1402	20435										
SH3KBP1	30011	broad.mit.edu	37	chrX	19560286	19560286	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccatggtccccggcttgggcGgcagggatgctttgttgtca	15	11	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:19560286G>A	uc004czm.2	-	16	1965	c.1649C>T	c.(1648-1650)CCG>CTG	p.P550L	SH3KBP1_uc011mje.1_Missense_Mutation_p.P289L|SH3KBP1_uc011mjf.1_Missense_Mutation_p.P312L|SH3KBP1_uc004czl.2_Missense_Mutation_p.P513L|SH3KBP1_uc010nfm.2_5'UTR	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	550					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CGGCTTGGGCGGCAGGGATGC	0.632													0	0	0	1	0	31	37										A	19560286	G	A	19560286	3	1	65	1	0	0	0	0	1	0	0	0	14255	1116	39	2	360	2	SH3KBP1	23	19560286	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4248948	19560286	135710274	1403	20436										
SH3KBP1	30011	broad.mit.edu	37	chrX	19713821	19713821	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttggaaggaaacattccagtCttcccgttgagaacaccttc	8	11	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:19713821C>G	uc004czm.2	-	5	745	c.429G>C	c.(427-429)AAG>AAC	p.K143N	SH3KBP1_uc004czl.2_Missense_Mutation_p.K106N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	143	SH3 2.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						ACATTCCAGTCTTCCCGTTGA	0.483													0	0	0	1	0	31	37										G	19713821	C	G	19713821	3	3	65	1	0	0	0	0	1	0	0	0	14255	912	32	1	1640	1	SH3KBP1	23	19713821	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	153535	19713821	135556739	1404	20437										
FAM47C	442444	broad.mit.edu	37	chrX	37027545	37027545	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gagactggagtgtcccatctCtgcccggaacctccagagac	11	14	1	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:37027545C>G	uc004ddl.1	+	1	1076	c.1062C>G	c.(1060-1062)CTC>CTG	p.L354L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	354										ovary(3)	3						TGTCCCATCTCTGCCCGGAAC	0.627													0	0	0	1	0	73	50										G	37027545	C	G	37027545	2	3	65	1	0	0	0	0	0	0	0	1	5571	900	32	1		1	FAM47C	23	37027545	Silent	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	17313724	37027545	118243015	1405	20438										
TSPAN7	7102	broad.mit.edu	37	chrX	38525537	38525537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttggatgctttgctacatgtCgtggtagcccatggatgctg	13	8	0	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:38525537C>T	uc004deg.3	+	2	313	c.244C>T	c.(244-246)CGT>TGT	p.R82C	TSPAN7_uc011mkj.1_Missense_Mutation_p.R108C|TSPAN7_uc011mkk.1_Missense_Mutation_p.R99C|TSPAN7_uc004deh.2_5'UTR	NM_004615	NP_004606	P41732	TSN7_HUMAN	tetraspanin 7	82	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to plasma membrane				ovary(1)	1						TGCTACATGTCGTGGTAGCCC	0.418													0	0	0	1	0	11	23										T	38525537	C	T	38525537	3	4	65	1	0	0	0	0	1	0	0	0	16649	884	31	1	250	1	TSPAN7	23	38525537	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1497992	38525537	116745023	1406	20439										
CDK16	5127	broad.mit.edu	37	chrX	47082968	47082968	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cagatcgccatggatcggatGaagaagatcaaacggcagct	12	9	1	4			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:47082968G>A	uc004dho.2	+	2	408	c.12G>A	c.(10-12)ATG>ATA	p.M4I	CDK16_uc011mli.1_Missense_Mutation_p.M10I|CDK16_uc011mlj.1_Missense_Mutation_p.M4I|CDK16_uc011mlk.1_Missense_Mutation_p.M4I|CDK16_uc011mll.1_Missense_Mutation_p.M78I	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	4							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						TGGATCGGATGAAGAAGATCA	0.527													0	0	0	1	0	13	13										A	47082968	G	A	47082968	3	1	65	1	0	0	0	0	1	0	0	0	3132	1290	45	1	256	1	CDK16	23	47082968	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	8557431	47082968	108187592	1407	20440										
GRIPAP1	56850	broad.mit.edu	37	chrX	48846411	48846411	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtttctttttcagtttctcgGagagctggggagagaggtac	14	6	3	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:48846411G>A	uc004dly.1	-	9	730	c.695C>T	c.(694-696)TCC>TTC	p.S232F	GRIPAP1_uc004dlz.2_Missense_Mutation_p.S122F|GRIPAP1_uc004dma.2_Missense_Mutation_p.S179F	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	232	Potential.					early endosome				breast(2)|kidney(1)	3						CAGTTTCTCGGAGAGCTGGGG	0.338													0	0	0	1	0	6	5										A	48846411	G	A	48846411	3	1	65	1	0	0	0	0	1	0	0	0	6789	1174	41	1	1956	1	GRIPAP1	23	48846411	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1763443	48846411	106424149	1408	20441										
KDM5C	8242	broad.mit.edu	37	chrX	53222481	53222481	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cctctccagggcccggccccGagcccgactcccgtgacgct	11	21	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:53222481G>T	uc004drz.2	-	26	4884	c.4351C>A	c.(4351-4353)CGG>AGG	p.R1451R	KDM5C_uc011moc.1_Intron|KDM5C_uc011mod.1_Intron|KDM5C_uc004dsa.2_Silent_p.R1450R|uc004dsb.1_Intron	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	1451					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						GCCCGGCCCCGAGCCCGACTC	0.677			N|F|S		clear cell renal carcinoma								1	0	1.2644e-06	1	1.30368e-06	16	15										T	53222481	G	T	53222481	2	4	65	1	0	0	0	0	0	0	0	1	8135	1057	37	3		3	KDM5C	23	53222481	Silent	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	4376070	53222481	102048079	1409	20442										
SPIN3	169981	broad.mit.edu	37	chrX	57021092	57021092	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tctttcatctctgtgaagttCcaatccataaacacagtcaa	4	11	4	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:57021092C>G	uc010nkj.2	-	2	575	c.289G>C	c.(289-291)GAA>CAA	p.E97Q	SPIN3_uc004duu.3_Intron|SPIN3_uc004duw.3_Intron|SPIN3_uc004duv.3_Intron|SPIN3_uc004dux.1_Missense_Mutation_p.E97Q	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	97					gamete generation					ovary(1)|central_nervous_system(1)	2						CTGTGAAGTTCCAATCCATAA	0.398													0	0	0	1	0	50	57										G	57021092	C	G	57021092	3	3	65	1	0	0	0	0	1	0	0	0	15054	864	30	1	491	1	SPIN3	23	57021092	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	3798611	57021092	98249468	1410	20443										
HEPH	9843	broad.mit.edu	37	chrX	65390566	65390566	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	atgtcatcacgaaccagcctCtggacagtgacatgtaggtt	10	10	3	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:65390566C>G	uc011moz.1	+	2	223	c.163C>G	c.(163-165)CTG>GTG	p.L55V	HEPH_uc004dwn.2_Missense_Mutation_p.L55V|HEPH_uc004dwo.2_Intron|HEPH_uc010nkr.2_Missense_Mutation_p.L55V|HEPH_uc011mpa.1_Missense_Mutation_p.L55V	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	52	Extracellular (Potential).|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						GAACCAGCCTCTGGACAGTGA	0.507													0	0	0	1	0	9	11										G	65390566	C	G	65390566	3	3	65	1	0	0	0	0	1	0	0	0	7054	912	32	1	322	1	HEPH	23	65390566	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8369474	65390566	89879994	1411	20444										
STARD8	9754	broad.mit.edu	37	chrX	67938374	67938374	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gtagtgggaactccatgaatGaggctgaggctgcggggccc	17	9	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:67938374G>A	uc004dxa.2	+	5	1750	c.1378G>A	c.(1378-1380)GAG>AAG	p.E460K	STARD8_uc004dxb.2_Missense_Mutation_p.E540K|STARD8_uc004dxc.3_Missense_Mutation_p.E460K	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	460					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						CTCCATGAATGAGGCTGAGGC	0.592													0	0	0	1	0	14	14										A	67938374	G	A	67938374	3	1	65	1	0	0	0	0	1	0	0	0	15262	1291	45	1	1640	1	STARD8	23	67938374	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2547808	67938374	87332186	1412	20445										
MED12	9968	broad.mit.edu	37	chrX	70338683	70338683	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcctcccgatgtttaccctCaggaccccaaacagaaggag	10	14	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:70338683C>G	uc004dyy.2	+	1	278	c.79C>G	c.(79-81)CAG>GAG	p.Q27E	MED12_uc011mpq.1_Missense_Mutation_p.Q27E|MED12_uc004dyz.2_Missense_Mutation_p.Q27E|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	27					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGTTTACCCTCAGGACCCCAA	0.677													0	0	0	1	0	12	14										G	70338683	C	G	70338683	3	3	65	1	0	0	0	0	1	0	0	0	9428	827	29	1	81	1	MED12	23	70338683	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	2400309	70338683	84931877	1413	20446										
ZMYM3	9203	broad.mit.edu	37	chrX	70465551	70465551	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgaggccttgtctaactcctCagcctctgcaatcatttctg	7	13	5	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:70465551C>T	uc004dzh.1	-	17	2914	c.2827G>A	c.(2827-2829)GAG>AAG	p.E943K	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.E943K|ZMYM3_uc004dzj.1_Missense_Mutation_p.E931K	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	943					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCTAACTCCTCAGCCTCTGCA	0.547													0	0	0	1	0	10	12										T	70465551	C	T	70465551	3	4	65	1	0	0	0	0	1	0	0	0	17698	835	29	1	1321	1	ZMYM3	23	70465551	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	126868	70465551	84805009	1414	20447										
PHKA1	5255	broad.mit.edu	37	chrX	71915560	71915560	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttctctccttgtactgacctGaggcagtcatttgggctaag	10	10	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:71915560G>A	uc004eax.3	-	4	753	c.452C>T	c.(451-453)TCA>TTA	p.S151L	PHKA1_uc004eay.3_Missense_Mutation_p.S151L|PHKA1_uc011mqi.1_Missense_Mutation_p.S151L	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	151					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					GTACTGACCTGAGGCAGTCAT	0.498													0	0	0	1	0	16	19										A	71915560	G	A	71915560	3	1	65	1	0	0	0	0	1	0	0	0	11843	1294	45	1	3335	1	PHKA1	23	71915560	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1450009	71915560	83355000	1415	20448										
POU3F4	5456	broad.mit.edu	37	chrX	82763834	82763834	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	gcctgcacccggtgctccgaGagcccccggatcacggcgaa	13	17	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:82763834G>A	uc004eeg.2	+	1	566	c.502G>A	c.(502-504)GAG>AAG	p.E168K		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	168					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGTGCTCCGAGAGCCCCCGGA	0.637													0	0	0	1	0	10	6										A	82763834	G	A	82763834	3	1	65	1	0	0	0	0	1	0	0	0	12277	943	33	1	504	1	POU3F4	23	82763834	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	10848274	82763834	72506726	1416	20449										
RPS6KA6	27330	broad.mit.edu	37	chrX	83361413	83361413	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tggtagttgcatgtatgcatCgcttgcaaacagagtaggag	13	6	0	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:83361413C>T	uc004eej.1	-	15	1402	c.1325G>A	c.(1324-1326)CGA>CAA	p.R442Q	RPS6KA6_uc011mqt.1_Missense_Mutation_p.R442Q|RPS6KA6_uc011mqu.1_Missense_Mutation_p.R339Q	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	442	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						ATGTATGCATCGCTTGCAAAC	0.353													0	0	0	1	0	4	7										T	83361413	C	T	83361413	3	4	65	1	0	0	0	0	1	0	0	0	13655	884	31	1	944	1	RPS6KA6	23	83361413	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	597579	83361413	71909147	1417	20450										
RAB9B	51209	broad.mit.edu	37	chrX	103080330	103080330	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	agtagtcacttgcctatcctCtttgtctaccttgttaccca	5	13	3	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:103080330C>T	uc004ell.1	-	3	670	c.385G>A	c.(385-387)GAG>AAG	p.E129K	RAB9B_uc004eli.1_Intron	NM_016370	NP_057454	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	129					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3						TGCCTATCCTCTTTGTCTACC	0.433													0	0	0	1	0	94	87										T	103080330	C	T	103080330	3	4	65	1	0	0	0	0	1	0	0	0	12959	922	32	1	224	1	RAB9B	23	103080330	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	19718917	103080330	52190230	1418	20451										
ZCCHC16	340595	broad.mit.edu	37	chrX	111698857	111698857	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgccaaacgttctcgagctCcggcaacgacaaataacaca	7	13	1	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:111698857C>T	uc004epo.1	+	3	1342	c.901C>T	c.(901-903)CCG>TCG	p.P301S		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	301							nucleic acid binding|zinc ion binding			ovary(1)	1						TTCTCGAGCTCCGGCAACGAC	0.478													0	0	0	1	0	22	25										T	111698857	C	T	111698857	3	4	65	1	0	0	0	0	1	0	0	0	17581	855	30	1	903	1	ZCCHC16	23	111698857	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	8618527	111698857	43571703	1419	20452										
ZCCHC12	170261	broad.mit.edu	37	chrX	117959628	117959628	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tttttaacaccctacaagctCaaggggagaaagcctccctt	7	12	1	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:117959628C>G	uc004equ.2	+	4	894	c.421C>G	c.(421-423)CAA>GAA	p.Q141E		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	141					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						cctacaagctcaaggggagaa	0													0	0	0	1	0	57	67										G	117959628	C	G	117959628	3	3	65	1	0	0	0	0	1	0	0	0	17578	827	29	1	423	1	ZCCHC12	23	117959628	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	6260771	117959628	37310932	1420	20453										
CUL4B	8450	broad.mit.edu	37	chrX	119669775	119669775	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ttgcctaggtaaaatgtcttGaaaatctcctgaagttttac	7	7	2	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:119669775G>C	uc004esw.2	-	18	2561	c.2124C>G	c.(2122-2124)TTC>TTG	p.F708L	CUL4B_uc010nqq.2_Missense_Mutation_p.F409L|CUL4B_uc004esv.2_Missense_Mutation_p.F690L	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	708					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						AAAATGTCTTGAAAATCTCCT	0.348													0	0	0	1	0	43	26										C	119669775	G	C	119669775	3	2	65	1	0	0	0	0	1	0	0	0	4058	1281	45	1	637	1	CUL4B	23	119669775	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	1710147	119669775	35600785	1421	20454										
FMR1NB	158521	broad.mit.edu	37	chrX	147088242	147088242	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cttgcaatctgagggaaaatCaggtggcaaagccttgtaat	11	7	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:147088242C>T	uc004fcm.2	+	3	492	c.418C>T	c.(418-420)CAG>TAG	p.Q140*		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	140	P-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGGAAAATCAGGTGGCAAA	0.378													0	0	0	1	0	29	30										T	147088242	C	T	147088242	4	4	65	1	0	0	0	0	0	1	0	0	5961	827	29	1	428	1	FMR1NB	23	147088242	Nonsense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	27418467	147088242	8182318	1422	20455										
MTM1	4534	broad.mit.edu	37	chrX	149807437	149807437	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	cattatttgcatttttaaatGaagaaaagtttaacgtggat	7	3	0	2			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:149807437G>A	uc004fef.3	+	7	542	c.466G>A	c.(466-468)GAA>AAA	p.E156K	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.E119K|MTM1_uc011mxz.1_Missense_Mutation_p.E41K|MTM1_uc010nte.2_Missense_Mutation_p.E24K	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	156					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATTTTTAAATGAAGAAAAGTT	0.348													0	0	0	1	0	23	27										A	149807437	G	A	149807437	3	1	65	1	0	0	0	0	1	0	0	0	9937	1291	45	1	488	1	MTM1	23	149807437	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08	2719195	149807437	5463123	1423	20456										
GABRA3	2556	broad.mit.edu	37	chrX	151358368	151358368	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ccactttaggtaaggaatttCtggcactgatactcaaggtg	10	8	2	1			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:151358368C>A	uc010ntk.1	-	9	1217	c.977G>T	c.(976-978)AGA>ATA	p.R326I		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	326					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TAAGGAATTTCTGGCACTGAT	0.458													1	0	1.66031e-10	1	1.73405e-10	20	29										A	151358368	C	A	151358368	3	1	65	1	0	0	0	0	1	0	0	0	6162	913	32	3	509	3	GABRA3	23	151358368	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1550931	151358368	3912192	1424	20457										
TREX2	11219	broad.mit.edu	37	chrX	152710201	152710201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	ggcctccaggctggggtcatCaggcggcaagtacatgggct	16	11	2	0			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrX:152710201C>T	uc010nue.1	-	3	930	c.814G>A	c.(814-816)GAT>AAT	p.D272N	TREX2_uc010nud.1_Missense_Mutation_p.D230N|TREX2_uc011myp.1_Missense_Mutation_p.D230N|HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA	NM_080701	NP_542432	Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	273					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			large_intestine(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGGGTCATCAGGCGGCAAG	0.687								Editing_and_processing_nucleases					0	0	0	1	0	5	3										T	152710201	C	T	152710201	3	4	65	1	0	0	0	0	1	0	0	0	16474	826	29	1	25	1	TREX2	23	152710201	Missense_Mutation	SNP	C	TCGA-DK-A3WW-01A-22D-A23M-08	1351833	152710201	2560359	1425	20458										
UTY	7404	broad.mit.edu	37	chrY	15478205	15478205	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.617937853107345	875	0	4.4099794022949	5.10565679044247	3.96903237091854	3.97544273548851e-05	0.000272003976638688	677	tgcctccaaagacttttggaGatactgaatagcatagcttt	8	8	0	3			TCGA-DK-A3WW-01A-22D-A23M-08	TCGA-DK-A3WW-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08aa63b7-bc56-419b-b07b-a3fabf2463f2	daddf34c-2e30-4c6e-8895-6a84a389f760	g.chrY:15478205G>A	uc004fsx.1	-	10	1813	c.808C>T	c.(808-810)CTC>TTC	p.L270F	UTY_uc004fsy.2_Missense_Mutation_p.L270F|UTY_uc004fsz.2_Missense_Mutation_p.L270F	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	270	TPR 5.				chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GACTTTTGGAGATACTGAATA	0.368													0	0	0	1	0	12	22										A	15478205	G	A	15478205	3	1	65	1	0	0	0	0	1	0	0	0	17104	942	33	1	3574	1	UTY	24	15478205	Missense_Mutation	SNP	G	TCGA-DK-A3WW-01A-22D-A23M-08		15478205	43895361	1426	20459										
ZMYM1	79830	broad.mit.edu	37	chr1	35579714	35579714	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	attaggttttgtaaagaagtAaaagaactccgaagtgctct	9	5	1	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:35579714A>C	uc001bym.2	+	11	2431	c.2283A>C	c.(2281-2283)GTA>GTC	p.V761V	ZMYM1_uc001byn.2_Silent_p.V761V|ZMYM1_uc010ohu.1_Silent_p.V742V|ZMYM1_uc001byo.2_Silent_p.V401V|ZMYM1_uc009vut.2_Silent_p.V686V	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	761						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTAAAGAAGTAAAAGAACTCC	0.318													0	0	0	0.010729	0	12	34										C	35579714	A	C	35579714	2	2	66	1	0	0	0	0	0	0	0	1	17696	349	13	5		5	ZMYM1	1	35579714	Silent	SNP	A	TCGA-DK-A3WX-01A-22D-A22Z-08		35579714	213670907	1	20460										
HECTD3	79654	broad.mit.edu	37	chr1	45475257	45475257	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tacttgacaatggtgcccttCttcatagtaagccgtaccca	7	12	2	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:45475257C>T	uc009vxk.2	-	5	956	c.858G>A	c.(856-858)AAG>AAA	p.K286K	HECTD3_uc001cmy.3_5'Flank|HECTD3_uc010olh.1_Silent_p.K2K|UROD_uc010oli.1_5'Flank|UROD_uc001cna.1_5'Flank|UROD_uc001cnb.1_5'Flank	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	286	DOC.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGGTGCCCTTCTTCATAGTAA	0.542													0	0	0	0.038395	0	18	88										T	45475257	C	T	45475257	2	4	66	1	0	0	0	0	0	0	0	1	7041	912	32	1		1	HECTD3	1	45475257	Silent	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	9895543	45475257	203775364	2	20461										
KCNA2	3737	broad.mit.edu	37	chr1	111147111	111147111	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ggcacattcacaggtcgcctCaatcggccccctgactggta	10	15	2	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:111147111C>T	uc001dzu.2	-	2	790	c.294G>A	c.(292-294)TTG>TTA	p.L98L	KCNA2_uc009wfv.1_Silent_p.L98L|KCNA2_uc009wfw.2_Silent_p.L98L	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	98						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CAGGTCGCCTCAATCGGCCCC	0.473													0	0	0	0.049695	0	21	65										T	111147111	C	T	111147111	2	4	66	1	0	0	0	0	0	0	0	1	8003	825	29	1		1	KCNA2	1	111147111	Silent	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	65671854	111147111	138103510	3	20462										
HMCN1	83872	broad.mit.edu	37	chr1	186107047	186107047	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	catcagttcagcatggtgggCggccatgtgaagggaatgct	15	8	2	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:186107047C>T	uc001grq.1	+	89	14096	c.13867C>T	c.(13867-13869)CGG>TGG	p.R4623W	HMCN1_uc001grs.1_Missense_Mutation_p.R192W	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4623	TSP type-1 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCATGGTGGGCGGCCATGTGA	0.468													0	0	0	0.038395	0	19	92										T	186107047	C	T	186107047	3	4	66	1	0	0	0	0	1	0	0	0	7220	759	27	2	14221	2	HMCN1	1	186107047	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	74959936	186107047	63143574	4	20463										
GALNT2	2590	broad.mit.edu	37	chr1	230391013	230391013	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ggcagcctggagatcatcccGtgcagccgtgtgggacacgt	15	12	1	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:230391013G>A	uc010pwa.1	+	11	1131	c.1059G>A	c.(1057-1059)CCG>CCA	p.P353P	GALNT2_uc010pvy.1_Silent_p.P315P|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	353	Lumenal (Potential).|Catalytic subdomain B.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				AGATCATCCCGTGCAGCCGTG	0.607													0	0	0	0.038395	0	18	103										A	230391013	G	A	230391013	2	1	66	1	0	0	0	0	0	0	0	1	6213	1132	40	2		2	GALNT2	1	230391013	Silent	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	44283966	230391013	18859608	5	20464										
NBAS	51594	broad.mit.edu	37	chr2	15542413	15542413	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ttggtcctgatcaggaataaTtttttgctgcagctacagaa	9	7	1	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr2:15542413T>C	uc002rcc.1	-	26	2976	c.2950A>G	c.(2950-2952)ATT>GTT	p.I984V	NBAS_uc010exl.1_Missense_Mutation_p.I56V|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	984										ovary(2)|liver(1)|skin(1)	4						TCAGGAATAATTTTTTGCTGC	0.348													0	0	0	0.021553	0	6	66										C	15542413	T	C	15542413	3	2	66	1	0	0	0	0	1	0	0	0	10186	1493	52	5	4273	5	NBAS	2	15542413	Missense_Mutation	SNP	T	TCGA-DK-A3WX-01A-22D-A22Z-08		15542413	227656960	6	20465										
SMEK2	57223	broad.mit.edu	37	chr2	55792049	55792049	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	aaacaatacctgttcagtttCtgattttgtctgtctttttc	5	8	4	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr2:55792049C>G	uc002rzc.2	-	14	2439	c.2064G>C	c.(2062-2064)CAG>CAC	p.Q688H	SMEK2_uc002rzb.2_Missense_Mutation_p.Q603H|SMEK2_uc002rzd.2_Missense_Mutation_p.Q656H|SMEK2_uc002ryz.2_Missense_Mutation_p.Q122H|SMEK2_uc002rza.2_Missense_Mutation_p.Q479H	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	688						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGTTCAGTTTCTGATTTTGTC	0.308													0	0	0	0.038147	0	8	37										G	55792049	C	G	55792049	3	3	66	1	0	0	0	0	1	0	0	0	14794	912	32	1	501	1	SMEK2	2	55792049	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	40249636	55792049	187407324	7	20466										
CNTNAP5	129684	broad.mit.edu	37	chr2	125521571	125521571	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	caggacgcttctggaacgccGtctcattttatacagaagcc	9	12	2	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr2:125521571G>A	uc002tno.2	+	16	2741	c.2377G>A	c.(2377-2379)GTC>ATC	p.V793I	CNTNAP5_uc010flu.2_Missense_Mutation_p.V794I	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	793	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTGGAACGCCGTCTCATTTTA	0.428													0	0	0	0.010729	0	10	81										A	125521571	G	A	125521571	3	1	66	1	0	0	0	0	1	0	0	0	3650	1145	40	2	2439	2	CNTNAP5	2	125521571	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	69729522	125521571	117677802	8	20467										
TOP2B	7155	broad.mit.edu	37	chr3	25686873	25686873	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gtgtcttcttctgatacactCtctcaacagacaacttcttt	4	12	6	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:25686873C>T	uc011awn.1	-	2	201	c.158G>A	c.(157-159)AGA>AAA	p.R53K	TOP2B_uc003cdj.2_Missense_Mutation_p.R48K	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	53					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CTGATACACTCTCTCAACAGA	0.358													0	0	0	0.0333	0	18	46										T	25686873	C	T	25686873	3	4	66	1	0	0	0	0	1	0	0	0	16363	913	32	1	4862	1	TOP2B	3	25686873	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		25686873	172335557	9	20468										
SCN10A	6336	broad.mit.edu	37	chr3	38739662	38739662	+	Frame_Shift_Del	DEL	G	G	-													0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	cctctggtgccattgctgttGggcagattggggtcacagta							TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:38739662delG	uc003ciq.2	-	27	5049	c.5049delC	c.(5047-5049)CCCfs	p.P1683fs		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1683	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CATTGCTGTTGGGCAGATTGG	0.582																		19	71	---	---								-	38739662	G	-	38739662	7	5	66	1	0	1	0	1	0	0	0	0	13912	1335	47	0	825	0	SCN10A	3	38739662	Frame_Shift_Del	DEL	G	TCGA-DK-A3WX-01A-22D-A22Z-08	13052789	38739662	159282768	10	20469										
RRP9	9136	broad.mit.edu	37	chr3	51967533	51967533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ataagagtgtcaggaaccagCagctgggggtacagggaccc	15	9	1	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:51967533C>T	uc003dbw.1	-	15	1456	c.1417G>A	c.(1417-1419)GCT>ACT	p.A473T		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	473					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		CAGGAACCAGCAGCTGGGGGT	0.527													0	0	0	0.047766	0	8	27										T	51967533	C	T	51967533	3	4	66	1	0	0	0	0	1	0	0	0	13691	710	25	2	14	2	RRP9	3	51967533	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	13227871	51967533	146054897	11	20470										
GTF2E1	2960	broad.mit.edu	37	chr3	120469446	120469446	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	agttccagcagcattgaagcGgttagccaagtatgtgatcc	11	9	0	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:120469446G>A	uc003edz.3	+	2	161	c.47G>A	c.(46-48)CGG>CAG	p.R16Q	GTF2E1_uc003edy.2_Missense_Mutation_p.R16Q	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	16	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GCATTGAAGCGGTTAGCCAAG	0.433													0	0	0	0.02938	0	6	110										A	120469446	G	A	120469446	3	1	66	1	0	0	0	0	1	0	0	0	6856	1116	39	2	49	2	GTF2E1	3	120469446	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	68501913	120469446	77552984	12	20471										
SH3TC1	54436	broad.mit.edu	37	chr4	8230053	8230053	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tggctctgaagaggacgggcCggacgaggcaggcagctgag	19	9	1	3	rs116515695	byFrequency	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:8230053C>T	uc003gkv.3	+	12	2733	c.2632C>T	c.(2632-2634)CGG>TGG	p.R878W	SH3TC1_uc003gkw.3_Missense_Mutation_p.R802W|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	878	TPR 5.						binding			large_intestine(2)|pancreas(1)	3						GAGGACGGGCCGGACGAGGCA	0.677													0	0	0	0.009096	0	4	64										T	8230053	C	T	8230053	3	4	66	1	0	0	0	0	1	0	0	0	14261	643	23	2	2674	2	SH3TC1	4	8230053	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		8230053	182924223	13	20472										
C4orf17	84103	broad.mit.edu	37	chr4	100458840	100458840	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tgtcagatcctggcaaagctCtgtagcattttgcatactga	9	9	2	2	rs34271979	byFrequency	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:100458840C>G	uc003huw.2	+	6	884	c.561C>G	c.(559-561)CTC>CTG	p.L187L	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	187											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		TGGCAAAGCTCTGTAGCATTT	0.373													0	0	0	0.02938	0	7	69										G	100458840	C	G	100458840	2	3	66	1	0	0	0	0	0	0	0	1	2252	900	32	1		1	C4orf17	4	100458840	Silent	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	92228787	100458840	90695436	14	20473										
TACR3	6870	broad.mit.edu	37	chr4	104640578	104640578	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tacgccagggaccagagcgcGatgcgccaggacggctgcac	15	14	0	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:104640578G>A	uc003hxe.1	-	1	398	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	85	Helical; Name=1; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ACCAGAGCGCGATGCGCCAGG	0.647													0	0	0	0.047766	0	7	93										A	104640578	G	A	104640578	2	1	66	1	0	0	0	0	0	0	0	1	15504	1048	37	1		1	TACR3	4	104640578	Silent	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	4181738	104640578	86513698	15	20474										
FBXW7	55294	broad.mit.edu	37	chr4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gccatcatattgaacacagcGgactgctgcaacatgaccca	8	13	1	2	rs149680468		TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.01892	0	24	102										C	153247289	G	C	153247289	3	2	66	1	0	0	0	0	1	0	0	0	5769	1116	39	4	622	4	FBXW7	4	153247289	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	48606711	153247289	37906987	16	20475										
TRIO	7204	broad.mit.edu	37	chr5	14485268	14485268	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gtgacgtggtagagaccttcAttttgcattcatctagtcca	9	9	3	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr5:14485268A>G	uc003jff.2	+	47	6754	c.6748A>G	c.(6748-6750)ATT>GTT	p.I2250V	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.I1899V	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2250	PH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGAGACCTTCATTTTGCATTC	0.403													0	0	0	0.055883	0	20	135										G	14485268	A	G	14485268	3	3	66	1	0	0	0	0	1	0	0	0	16549	217	8	5	6934	5	TRIO	5	14485268	Missense_Mutation	SNP	A	TCGA-DK-A3WX-01A-22D-A22Z-08		14485268	166429992	17	20476										
EHMT2	10919	broad.mit.edu	37	chr6	31854612	31854612	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gctacctccaggtggttgttCaccacggcctccatcagtgg	11	14	2	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:31854612C>T	uc003nxz.1	-	17	2191	c.2181G>A	c.(2179-2181)GTG>GTA	p.V727V	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Silent_p.V518V|EHMT2_uc011don.1_Silent_p.V750V|EHMT2_uc003nya.1_Silent_p.V693V	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	727	ANK 3.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGTGGTTGTTCACCACGGCCT	0.637													0	0	0	0.034045	0	27	170										T	31854612	C	T	31854612	2	4	66	1	0	0	0	0	0	0	0	1	4984	813	29	1		1	EHMT2	6	31854612	Silent	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		31854612	139260455	18	20477										
EHMT2	10919	broad.mit.edu	37	chr6	31855596	31855596	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	cagggccttttccagggcctCccggcctggccccagtggca	13	17	0	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:31855596C>T	uc003nxz.1	-	14	1898	c.1888G>A	c.(1888-1890)GAG>AAG	p.E630K	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.E421K|EHMT2_uc011don.1_Missense_Mutation_p.E653K|EHMT2_uc003nya.1_Missense_Mutation_p.E596K	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	630					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TCCAGGGCCTCCCGGCCTGGC	0.662													0	0	0	0.055883	0	20	142										T	31855596	C	T	31855596	3	4	66	1	0	0	0	0	1	0	0	0	4984	864	30	1	1804	1	EHMT2	6	31855596	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	984	31855596	139259471	19	20478										
ZBTB9	221504	broad.mit.edu	37	chr6	33423481	33423481	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ctgtgggaggggagggaagtGaactgggagaagtgctgcaa	20	4	0	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:33423481G>C	uc003oeq.2	+	2	872	c.604G>C	c.(604-606)GAA>CAA	p.E202Q		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGGGAAGTGAACTGGGAGA	0.443													0	0	0	0.049695	0	19	106										C	33423481	G	C	33423481	3	2	66	1	0	0	0	0	1	0	0	0	17555	1291	45	1	606	1	ZBTB9	6	33423481	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	1567885	33423481	137691586	20	20479										
ADAT2	134637	broad.mit.edu	37	chr6	143755111	143755111	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tggccaccatttctgcatgtCgagtagcctgaaaagagaaa	10	9	1	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:143755111C>A	uc003qjj.2	-	3	255	c.209G>T	c.(208-210)CGA>CTA	p.R70L	ADAT2_uc003qjk.1_RNA	NM_182503	NP_872309	Q7Z6V5	ADAT2_HUMAN	deaminase domain containing 1	70					tRNA processing		hydrolase activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(155;5.61e-06)|GBM - Glioblastoma multiforme(68;0.0115)		TTCTGCATGTCGAGTAGCCTG	0.423													1	0	7.87624e-14	0.076483	8.66387e-14	22	146										A	143755111	C	A	143755111	3	1	66	1	0	0	0	0	1	0	0	0	285	884	31	3	382	3	ADAT2	6	143755111	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	110331630	143755111	27359956	21	20480										
KATNA1	11104	broad.mit.edu	37	chr6	149954043	149954044	+	Missense_Mutation	DNP	CC	CC	TT													0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tttagcttccacatttatttCctgccaaacctgatttcaaa							TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:149954043_149954044CC>TT	uc003qmr.1	-	2	216_217	c.171_172GG>AA	c.(169-174)CAGGAA>CAAAAA	p.E58K	KATNA1_uc003qms.2_Missense_Mutation_p.E58K|KATNA1_uc003qmt.2_Missense_Mutation_p.E58K|KATNA1_uc011eed.1_Missense_Mutation_p.E58K	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	58	Interaction with microtubule.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		ACATTTATTTCCTGCCAAACCT	0.356													0	0	0	0.004672	0	6	74										TT	149954044	CC	TT	149954043	3	4	66	1	0	0	0	0	1	0	0	0	7984	864	30	1	1339	1	KATNA1	6	149954043	Missense_Mutation	DNP	CC	TCGA-DK-A3WX-01A-22D-A22Z-08	6198932	149954043	21161024	22	20481										
ABCB5	340273	broad.mit.edu	37	chr7	20691117	20691117	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	catattggagtggttagtcaAgagcctgttttgttcgggac	13	6	1	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr7:20691117A>G	uc003suw.3	+	4	618	c.72A>G	c.(70-72)CAA>CAG	p.Q24Q	ABCB5_uc010kuh.2_Silent_p.Q469Q|ABCB5_uc003suv.3_Silent_p.Q24Q|ABCB5_uc011jyi.1_Silent_p.Q24Q	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	24	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGGTTAGTCAAGAGCCTGTTT	0.438													0	0	0	0.076483	0	24	96										G	20691117	A	G	20691117	2	3	66	1	0	0	0	0	0	0	0	1	44	69	3	5		5	ABCB5	7	20691117	Silent	SNP	A	TCGA-DK-A3WX-01A-22D-A22Z-08		20691117	138447546	23	20482										
ZMIZ2	83637	broad.mit.edu	37	chr7	44802942	44802942	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gcagacagctatcaaggtgtCcctgaagtgccccatcacct	9	14	2	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr7:44802942C>A	uc003tlr.2	+	13	1913	c.1790C>A	c.(1789-1791)TCC>TAC	p.S597Y	ZMIZ2_uc003tlq.2_Missense_Mutation_p.S539Y|ZMIZ2_uc003tls.2_Missense_Mutation_p.S571Y|ZMIZ2_uc003tlt.2_Missense_Mutation_p.S220Y|ZMIZ2_uc010kyj.2_Missense_Mutation_p.S119Y|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	597	SP-RING-type.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						ATCAAGGTGTCCCTGAAGTGC	0.592													1	0	1.66031e-10	0.021523	1.7756e-10	27	134										A	44802942	C	A	44802942	3	1	66	1	0	0	0	0	1	0	0	0	17694	855	30	3	1836	3	ZMIZ2	7	44802942	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	24111825	44802942	114335721	24	20483										
CNTNAP2	26047	broad.mit.edu	37	chr7	147092873	147092873	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	atgtgtgcgatcatagacagGtaaatgatcttttcatccta	8	7	3	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr7:147092873G>A	uc003weu.1	+	10	2186	c.1670_splice	c.e10+1	p.R557_splice		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor						behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCATAGACAGGTAAATGATCT	0.398										HNSCC(39;0.1)			0	0	0	0.024245	0	15	117										A	147092873	G	A	147092873	5	1	66	1	0	0	0	0	0	0	1	0	3647	1275	44	2	1709	2	CNTNAP2	7	147092873	Splice_Site	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	102289931	147092873	12045790	25	20484										
MYBL1	4603	broad.mit.edu	37	chr8	67514656	67514656	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ccttgtcagataattacctcGtcccttgtccattttactct	4	13	2	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr8:67514656G>A	uc003xwj.2	-	2	530	c.123C>T	c.(121-123)GAC>GAT	p.D41D	MYBL1_uc003xwl.2_Silent_p.D41D|MYBL1_uc003xwk.2_Silent_p.D41D	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	41	HTH myb-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			TAATTACCTCGTCCCTTGTCC	0.308													0	0	0	0.028581	0	14	54										A	67514656	G	A	67514656	2	1	66	1	0	0	0	0	0	0	0	1	10009	1136	40	2		2	MYBL1	8	67514656	Silent	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08		67514656	78849366	26	20485										
TP53INP1	94241	broad.mit.edu	37	chr8	95952380	95952380	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ggaaaagactgaagggtgctCagtaggtgactcttcactga	13	7	3	4			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr8:95952380C>T	uc003yhg.2	-	3	565	c.181G>A	c.(181-183)GAG>AAG	p.E61K	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_Missense_Mutation_p.E61K	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	61	Glu-rich.				apoptosis	PML body					0	Breast(36;8.75e-07)					GAAGGGTGCTCAGTAGGTGAC	0.463													0	0	0	0.028581	0	17	43										T	95952380	C	T	95952380	3	4	66	1	0	0	0	0	1	0	0	0	16385	835	29	1	575	1	TP53INP1	8	95952380	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	28437724	95952380	50411642	27	20486										
KIAA0196	9897	broad.mit.edu	37	chr8	126087241	126087241	+	Frame_Shift_Del	DEL	T	T	-													0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tccccagattagaacctaccTgttctctgacatttgaaagg							TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr8:126087241delT	uc003yrt.2	-	8	1306	c.977delA	c.(976-978)CAGfs	p.Q326fs	KIAA0196_uc011lir.1_Frame_Shift_Del_p.Q178fs	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	326					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGAACCTACCTGTTCTCTGAC	0.388																		12	95	---	---								-	126087241	T	-	126087241	7	5	66	1	0	1	0	1	0	0	0	0	8161	1594	55	0	2590	0	KIAA0196	8	126087241	Frame_Shift_Del	DEL	T	TCGA-DK-A3WX-01A-22D-A22Z-08	30134861	126087241	20276781	28	20487										
C11orf16	56673	broad.mit.edu	37	chr11	8947080	8947080	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tcaggctggcagaggccactCtgtctcagaggcatctcaag	12	12	4	2	rs146836226	byFrequency	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:8947080C>T	uc001mhb.3	-	5	1258	c.1134G>A	c.(1132-1134)CAG>CAA	p.Q378Q	C11orf16_uc001mhc.3_Silent_p.Q378Q	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	378										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGAGGCCACTCTGTCTCAGAG	0.547													0	0	0	0.043863	0	18	78										T	8947080	C	T	8947080	2	4	66	1	0	0	0	0	0	0	0	1	1631	912	32	1		1	C11orf16	11	8947080	Silent	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		8947080	126059436	29	20488										
NADSYN1	55191	broad.mit.edu	37	chr11	71195380	71195380	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	accacatcagtctcaacatcGatccagccgtgaaggccgtc	8	15	2	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:71195380G>T	uc001oqn.2	+	15	1468	c.1342G>T	c.(1342-1344)GAT>TAT	p.D448Y	NADSYN1_uc001oqo.2_Missense_Mutation_p.D188Y|NADSYN1_uc001oqp.2_Missense_Mutation_p.D77Y	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	448	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCTCAACATCGATCCAGCCGT	0.582													1	0	1.08611e-07	0.010729	1.14562e-07	9	54										T	71195380	G	T	71195380	3	4	66	1	0	0	0	0	1	0	0	0	10138	1058	37	3	1400	3	NADSYN1	11	71195380	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	62248300	71195380	63811136	30	20489										
CCDC82	79780	broad.mit.edu	37	chr11	96117437	96117437	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tccagtttgtttgttgagatCattatcctcttgacttaaat	6	7	2	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:96117437C>A	uc009ywp.2	-	1	718	c.475G>T	c.(475-477)GAT>TAT	p.D159Y	CCDC82_uc009ywq.2_Missense_Mutation_p.D159Y|CCDC82_uc001pfx.3_Missense_Mutation_p.D159Y|CCDC82_uc009ywr.2_Missense_Mutation_p.D159Y|CCDC82_uc009yws.2_Missense_Mutation_p.D159Y	NM_024725	NP_079001	Q8N4S0	CCD82_HUMAN	coiled-coil domain containing 82	159							protein binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)		TTGTTGAGATCATTATCCTCT	0.343													1	0	6.36457e-07	0.021523	6.6226e-07	27	107										A	96117437	C	A	96117437	3	1	66	1	0	0	0	0	1	0	0	0	2856	826	29	3	1187	3	CCDC82	11	96117437	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	24922057	96117437	38889079	31	20490										
ACAT1	38	broad.mit.edu	37	chr11	108016949	108016950	+	Frame_Shift_Ins	INS	-	-	A													0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ttcttaaagatgtgggattgINSaaaaaagaagatattgcaat							TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:108016949_108016950insA	uc001pjy.2	+	11	1102_1103	c.1026_1027insA	c.(1024-1029)TTGAAAfs	p.L342fs		NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	342_343					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	ATGTGGGATTGAAAAAAGAAGA	0.307																		44	175	---	---								A	108016950	-	A	108016949	7	5	66	1	0	1	1	0	0	0	0	0	121	1281	45	0	1068	0	ACAT1	11	108016949	Frame_Shift_Ins	INS	-	TCGA-DK-A3WX-01A-22D-A22Z-08	11899512	108016949	26989567	32	20491										
HDAC7	51564	broad.mit.edu	37	chr12	48177866	48177866	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	aggggtctggcattacctatCttcagccaggatgcccacag	11	12	3	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr12:48177866C>T	uc010slo.1	-	25	3121	c.2926G>A	c.(2926-2928)GAT>AAT	p.D976N	HDAC7_uc009zku.2_RNA|HDAC7_uc001rqe.2_Missense_Mutation_p.D410N|HDAC7_uc001rqj.3_Missense_Mutation_p.D939N|HDAC7_uc001rqk.3_Missense_Mutation_p.D959N	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	937	Interaction with SIN3A (By similarity).|Nuclear export signal (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		CATTACCTATCTTCAGCCAGG	0.627													0	0	0	0.038147	0	7	44										T	48177866	C	T	48177866	3	4	66	1	0	0	0	0	1	0	0	0	7012	913	32	1	57	1	HDAC7	12	48177866	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		48177866	85674029	33	20492										
OR4N5	390437	broad.mit.edu	37	chr14	20612277	20612277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ccgctacatcgccatctgccGgcctttacactattcaacca	5	17	2	0	rs139546094		TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr14:20612277G>A	uc010tla.1	+	1	383	c.383G>A	c.(382-384)CGG>CAG	p.R128Q		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GCCATCTGCCGGCCTTTACAC	0.488													0	0	0	0.074837	0	38	199										A	20612277	G	A	20612277	3	1	66	1	0	0	0	0	1	0	0	0	11079	1116	39	2	385	2	OR4N5	14	20612277	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08		20612277	86737263	34	20493										
BAZ1A	11177	broad.mit.edu	37	chr14	35234031	35234031	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	atcctcacctcccatactgtCttccacatcttcatcacttt	1	17	5	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr14:35234031C>G	uc001wsk.2	-	23	4226	c.3658G>C	c.(3658-3660)GAC>CAC	p.D1220H	BAZ1A_uc001wsl.2_Missense_Mutation_p.D1188H	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1220					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CCCATACTGTCTTCCACATCT	0.264													0	0	0	0.028581	0	16	121										G	35234031	C	G	35234031	3	3	66	1	0	0	0	0	1	0	0	0	1329	913	32	1	1032	1	BAZ1A	14	35234031	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	14621754	35234031	72115509	35	20494										
EHD4	30844	broad.mit.edu	37	chr15	42193059	42193059	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gaggtcaccatctccttcttGgcgttgacacctgatatctt	8	12	4	2			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr15:42193059G>A	uc001zot.2	-	6	1473	c.1410C>T	c.(1408-1410)GCC>GCT	p.A470A		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	470	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TCTCCTTCTTGGCGTTGACAC	0.582													0	0	0	0.020292	0	14	59										A	42193059	G	A	42193059	2	1	66	1	0	0	0	0	0	0	0	1	4980	1335	47	2		2	EHD4	15	42193059	Silent	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08		42193059	60338333	36	20495										
MBD1	4152	broad.mit.edu	37	chr18	47800573	47800573	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	caccatggcaaactgcaggcAttggcgccaacgacacttct	9	14	1	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr18:47800573A>G	uc010dow.1	-	11	1566	c.1129T>C	c.(1129-1131)TGC>CGC	p.C377R	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_Missense_Mutation_p.C327R|MBD1_uc010xdi.1_Missense_Mutation_p.C428R|MBD1_uc002leh.3_Intron|MBD1_uc002len.2_Missense_Mutation_p.C377R|MBD1_uc002lei.3_Missense_Mutation_p.C377R|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_Missense_Mutation_p.C328R|MBD1_uc002lel.3_Missense_Mutation_p.C354R|MBD1_uc002lem.3_Missense_Mutation_p.C377R|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_Missense_Mutation_p.C402R|MBD1_uc010dox.1_Missense_Mutation_p.C354R|MBD1_uc002leo.2_Missense_Mutation_p.C377R	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	377	CXXC-type 3.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AACTGCAGGCATTGGCGCCAA	0.642													0	0	0	0.045705	0	29	105										G	47800573	A	G	47800573	3	3	66	1	0	0	0	0	1	0	0	0	9342	217	8	5	906	5	MBD1	18	47800573	Missense_Mutation	SNP	A	TCGA-DK-A3WX-01A-22D-A22Z-08		47800573	30276675	37	20496										
ZNF799	90576	broad.mit.edu	37	chr19	12491949	12491949	+	Missense_Mutation	SNP	T	T	C													0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	cgagtggcaataactgaaggTtttccaaaattgtttacgtg					rs11668955	by1000genomes	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:12491949T>C	uc002mts.3	-	4	593	c.127A>G	c.(127-129)ACC>GCC	p.T43A				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TAACTGAAGGTTTTCCAAAAT	0.403													0	0	0	0.004672	0	3	26										C	12491949	T	C	12491949	3	2	66	1	0	0	0	0	1	0	0	0	18163	1740	60	5		5	ZNF799	19	12491949	Missense_Mutation	SNP	T	TCGA-DK-A3WX-01A-22D-A22Z-08		12491949	46637034	38	20497	102	2								
ZNF799	90576	broad.mit.edu	37	chr19	12491955	12491955	+	Missense_Mutation	SNP	A	A	C													0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gcaataactgaaggttttccAaaattgtttacgtgtattac					rs11668074	by1000genomes	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:12491955A>C	uc002mts.3	-	4	587	c.121T>G	c.(121-123)TGG>GGG	p.W41G				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						AAGGTTTTCCAAAATTGTTTA	0.408													0	0	0	0.004672	0	3	26										C	12491955	A	C	12491955	3	2	66	1	0	0	0	0	1	0	0	0	18163	145	5	5		5	ZNF799	19	12491955	Missense_Mutation	SNP	A	TCGA-DK-A3WX-01A-22D-A22Z-08	6	12491955	46637028	39	20498	102	2								
ZNF536	9745	broad.mit.edu	37	chr19	30935717	30935717	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	gaggtgcctgtgcccatgggCggcatgtcccaggaggccca	16	13	0	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:30935717C>T	uc002nsu.1	+	2	1386	c.1248C>T	c.(1246-1248)GGC>GGT	p.G416G	ZNF536_uc010edd.1_Silent_p.G416G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGCCCATGGGCGGCATGTCCC	0.627													0	0	0	0.016723	0	14	65										T	30935717	C	T	30935717	2	4	66	1	0	0	0	0	0	0	0	1	17971	755	27	2		2	ZNF536	19	30935717	Silent	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	18443762	30935717	28193266	40	20499										
SPIB	6689	broad.mit.edu	37	chr19	50927009	50927009	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ccgaggggaagggatccgagGcaggtatgcgggagtggctg	21	7	0	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:50927009G>T	uc002psd.2	+	5	512	c.487G>T	c.(487-489)GCA>TCA	p.A163S	SPIB_uc002pse.2_Splice_Site_p.E162_splice|SPIB_uc010ycc.1_Missense_Mutation_p.A72S	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	163					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GGGATCCGAGGCAGGTATGCG	0.647													1	0	0.00116845	0.021553	0.00118382	6	12										T	50927009	G	T	50927009	3	4	66	1	0	0	0	0	1	0	0	0	15049	1203	42	4	505	4	SPIB	19	50927009	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08	19991292	50927009	8201974	41	20500										
CEACAM18	729767	broad.mit.edu	37	chr19	51984784	51984784	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tgcctacctctagtagtgacCggatgacaatttccccagac	8	13	1	3			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:51984784C>T	uc002pwv.1	+	4	721	c.721C>T	c.(721-723)CGG>TGG	p.R241W		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	241						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGTAGTGACCGGATGACAAT	0.502													0	0	0	0.024245	0	13	48										T	51984784	C	T	51984784	3	4	66	1	0	0	0	0	1	0	0	0	3189	643	23	2	735	2	CEACAM18	19	51984784	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	1057775	51984784	7144199	42	20501										
FLRT3	23767	broad.mit.edu	37	chr20	14306771	14306771	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ctgtgaccaagtactcactgCgttcccctgttacaattgtt	7	12	1	1	rs147588771		TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr20:14306771C>T	uc002wov.1	-	3	1849	c.1382G>A	c.(1381-1383)CGC>CAC	p.R461H	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R461H	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	461	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GTACTCACTGCGTTCCCCTGT	0.463													0	0	0	0.010729	0	12	147										T	14306771	C	T	14306771	3	4	66	1	0	0	0	0	1	0	0	0	5940	768	27	2	571	2	FLRT3	20	14306771	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		14306771	48718749	43	20502										
MN1	4330	broad.mit.edu	37	chr22	28195117	28195117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	tgtgcatgctgccgttccacGaagcgcagcggtccactccc	11	16	0	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr22:28195117G>A	uc003adj.2	-	1	2370	c.1415C>T	c.(1414-1416)TCG>TTG	p.S472L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	472							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GCCGTTCCACGAAGCGCAGCG	0.662			T	ETV6	AML|meningioma								0	0	0	0.058154	0	9	34										A	28195117	G	A	28195117	3	1	66	1	0	0	0	0	1	0	0	0	9673	1059	37	1	2555	1	MN1	22	28195117	Missense_Mutation	SNP	G	TCGA-DK-A3WX-01A-22D-A22Z-08		28195117	23109449	44	20503										
EP300	2033	broad.mit.edu	37	chr22	41566487	41566487	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	ccattgccatcctcctgaccAgaagatacccaagcccaagc	6	17	0	3			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr22:41566487A>G	uc003azl.3	+	27	4759	c.4364A>G	c.(4363-4365)CAG>CGG	p.Q1455R		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1455					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CCTCCTGACCAGAAGATACCC	0.448			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.055883	0	21	95										G	41566487	A	G	41566487	3	3	66	1	0	0	0	0	1	0	0	0	5148	188	7	5	4470	5	EP300	22	41566487	Missense_Mutation	SNP	A	TCGA-DK-A3WX-01A-22D-A22Z-08	13371370	41566487	9738079	45	20504										
TIMM17B	10245	broad.mit.edu	37	chrX	48752377	48752377	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	cactacctctcaaccggtgcCgaattccctggggaaaggaa	10	13	1	0			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chrX:48752377C>T	uc004dlc.1	-	4	283	c.134G>A	c.(133-135)CGG>CAG	p.R45Q	PQBP1_uc004dle.2_5'Flank|PQBP1_uc004dlf.2_5'Flank|PQBP1_uc004dlg.2_5'Flank|PQBP1_uc004dld.2_5'Flank|TIMM17B_uc004dla.1_Missense_Mutation_p.R95Q|TIMM17B_uc004dlb.1_Missense_Mutation_p.R65Q	NM_005834	NP_005825	O60830	TI17B_HUMAN	translocase of inner mitochondrial membrane 17	45					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CAACCGGTGCCGAATTCCCTG	0.547													0	0	0	0.014758	0	5	14										T	48752377	C	T	48752377	3	4	66	1	0	0	0	0	1	0	0	0	15906	652	23	2	400	2	TIMM17B	23	48752377	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08		48752377	106518183	46	20505										
MAGEC1	9947	broad.mit.edu	37	chrX	140995948	140995948	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.260869565217391	12	0.000878127780341542	2.76850393700787	5.53700787401575	2.2148031496063	0.237743976309059	0.417658336759158	8	acgagttggcgcggtttcttCtcctcaaatatcaagtgaag	10	9	4	1			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chrX:140995948C>T	uc004fbt.2	+	4	3044	c.2758C>T	c.(2758-2760)CTC>TTC	p.L920F	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	920	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GCGGTTTCTTCTCCTCAAATA	0.483										HNSCC(15;0.026)			0	0	0	0.048971	0	75	278										T	140995948	C	T	140995948	3	4	66	1	0	0	0	0	1	0	0	0	9180	913	32	1	2764	1	MAGEC1	23	140995948	Missense_Mutation	SNP	C	TCGA-DK-A3WX-01A-22D-A22Z-08	92243571	140995948	14274612	47	20506										
SH2D1B	117157	broad.mit.edu	37	chr1	162368847	162368847	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	gatcagttcctttaggcttgGaaagacctgttttggagaac	11	7	1	2			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr1:162368847G>C	uc001gbz.1	-	3	351	c.229C>G	c.(229-231)CCA>GCA	p.P77A	SH2D1B_uc001gca.1_Intron	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	77	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TTTAGGCTTGGAAAGACCTGT	0.408													0	0	0	0.021553	0	5	60										C	162368847	G	C	162368847	3	2	67	1	0	0	0	0	1	0	0	0	14231	1174	41	1	177	1	SH2D1B	1	162368847	Missense_Mutation	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08		162368847	86881774	1	20507										
RBM5	10181	broad.mit.edu	37	chr3	50155783	50155783	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	ggctcaagttcggctaaaggGagctggcctaggagccaaag	15	9	1	0			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:50155783G>C	uc003cyg.2	+	25	2490	c.2342G>C	c.(2341-2343)GGA>GCA	p.G781A	RBM5_uc011bdk.1_Missense_Mutation_p.G609A|RBM5_uc003cyh.2_Missense_Mutation_p.G238A|uc003cyi.1_Intron	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	781	G-patch.|Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGGCTAAAGGGAGCTGGCCTA	0.572													0	0	0	0.115264	0	3	27										C	50155783	G	C	50155783	3	2	67	1	0	0	0	0	1	0	0	0	13143	1174	41	1	2436	1	RBM5	3	50155783	Missense_Mutation	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08		50155783	147866647	2	20508										
ARL6	84100	broad.mit.edu	37	chr3	97506888	97506888	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	tgcaaataaaatggatcttaGagatgcagtgacatctgtaa	9	5	2	2			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:97506888G>C	uc003drv.2	+	7	717	c.404G>C	c.(403-405)AGA>ACA	p.R135T	ARL6_uc003drw.2_RNA|ARL6_uc003dru.2_Missense_Mutation_p.R135T|ARL6_uc010hoy.2_Missense_Mutation_p.R135T	NM_177976	NP_816931	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	135					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		ATGGATCTTAGAGATGCAGTG	0.318									Bardet-Biedl_syndrome				0	0	0	0.150653	0	4	57										C	97506888	G	C	97506888	3	2	67	1	0	0	0	0	1	0	0	0	941	942	33	1	422	1	ARL6	3	97506888	Missense_Mutation	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08	47351105	97506888	100515542	3	20509										
GPR87	53836	broad.mit.edu	37	chr3	151011992	151011992	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	atcataatatatgcgaacttCcgatcttctcacactttgca	4	11	3	0			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:151011992C>G	uc003eyt.2	-	3	1403	c.1042G>C	c.(1042-1044)GAA>CAA	p.E348Q	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	348	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATGCGAACTTCCGATCTTCTC	0.338													0	0	0	0.105934	0	13	161										G	151011992	C	G	151011992	3	3	67	1	0	0	0	0	1	0	0	0	6716	864	30	1	38	1	GPR87	3	151011992	Missense_Mutation	SNP	C	TCGA-DK-A3WY-01A-11D-A22Z-08	53505104	151011992	47010438	4	20510			1	93		2	2	115	C		5.155444e-05
GPR87	53836	broad.mit.edu	37	chr3	151012106	151012106	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	gaaaaagtaaattattggatCcaggcaaacattacacgcag	8	7	0	0			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr3:151012106C>G	uc003eyt.2	-	3	1289	c.928G>C	c.(928-930)GAT>CAT	p.D310H	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	310	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTATTGGATCCAGGCAAACA	0.343													0	0	0	0.09319	0	13	128										G	151012106	C	G	151012106	3	3	67	1	0	0	0	0	1	0	0	0	6716	855	30	1	152	1	GPR87	3	151012106	Missense_Mutation	SNP	C	TCGA-DK-A3WY-01A-11D-A22Z-08	114	151012106	47010324	5	20511			1	93		2	2	115	C		5.155444e-05
WDFY3	23001	broad.mit.edu	37	chr4	85617303	85617303	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	attaagtcaatccactcatgTagatgggcactcacgtaatc	7	10	3	1			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr4:85617303T>C	uc003hpd.2	-	58	9129	c.8721A>G	c.(8719-8721)CTA>CTG	p.L2907L	WDFY3_uc003hpe.1_Silent_p.L518L	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2907	BEACH.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TCCACTCATGTAGATGGGCAC	0.413													0	0	0	0.038147	0	7	137										C	85617303	T	C	85617303	2	2	67	1	0	0	0	0	0	0	0	1	17267	1625	57	5		5	WDFY3	4	85617303	Silent	SNP	T	TCGA-DK-A3WY-01A-11D-A22Z-08		85617303	105536973	6	20512										
PECI	10455	broad.mit.edu	37	chr6	4116175	4116175	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	attcatctgatagccatcttCcctgaaggacattgcattct	6	11	4	2			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr6:4116175C>T	uc003mwf.2	-	10	1155	c.1118G>A	c.(1117-1119)GGA>GAA	p.G373E	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Missense_Mutation_p.G206E|PECI_uc003mwd.2_Missense_Mutation_p.G343E|PECI_uc003mwe.2_Missense_Mutation_p.G220E	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	373					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TAGCCATCTTCCCTGAAGGAC	0.403													0	0	0	0.184627	0	5	59										T	4116175	C	T	4116175	3	4	67	1	0	0	0	0	1	0	0	0	11716	855	30	1	70	1	PECI	6	4116175	Missense_Mutation	SNP	C	TCGA-DK-A3WY-01A-11D-A22Z-08		4116175	166998892	7	20513										
PARK2	5071	broad.mit.edu	37	chr6	161771157	161771157	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	gtcgaaccagtggtcccccaTgcagacgcggttccactcgc	11	16	0	1			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr6:161771157T>G	uc003qtx.3	-	12	1506	c.1372A>C	c.(1372-1374)ATG>CTG	p.M458L	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.M267L|PARK2_uc003qtw.3_3'UTR|PARK2_uc003qty.3_Missense_Mutation_p.M430L|PARK2_uc003qtz.3_Missense_Mutation_p.M309L|PARK2_uc011egf.1_Missense_Mutation_p.M132L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	458					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TGGTCCCCCATGCAGACGCGG	0.622													0	0	0	0.115264	0	3	11										G	161771157	T	G	161771157	3	3	67	1	0	0	0	0	1	0	0	0	11449	1464	51	5	29	5	PARK2	6	161771157	Missense_Mutation	SNP	T	TCGA-DK-A3WY-01A-11D-A22Z-08	157654982	161771157	9343910	8	20514										
NPSR1	387129	broad.mit.edu	37	chr7	34851409	34851409	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	tgctctacgcctctacctacGtcctggtgtccctcagcata	7	16	3	0			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr7:34851409G>A	uc003teg.1	+	4	540	c.412G>A	c.(412-414)GTC>ATC	p.V138I	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Missense_Mutation_p.V138I|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_Intron|NPSR1_uc010kwv.1_Intron|NPSR1_uc003tei.1_Missense_Mutation_p.V138I|NPSR1_uc010kww.1_Missense_Mutation_p.V127I|NPSR1_uc011kar.1_Intron|AAA1_uc010kwy.2_Intron|AAA1_uc003tek.3_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	138	Helical; Name=3; (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	CTCTACCTACGTCCTGGTGTC	0.483													0	0	0	0.038147	0	6	98										A	34851409	G	A	34851409	3	1	67	1	0	0	0	0	1	0	0	0	10600	1145	40	2	426	2	NPSR1	7	34851409	Missense_Mutation	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08		34851409	124287254	9	20515										
C7orf63	79846	broad.mit.edu	37	chr7	89938595	89938595	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	agaaagcaaaaagccttcaaGaaaaagctatagaagcctcc	7	9	1	3			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr7:89938595G>C	uc010lep.2	+	22	2820	c.2569G>C	c.(2569-2571)GAA>CAA	p.E857Q	C7orf63_uc011khj.1_Missense_Mutation_p.E839Q|C7orf63_uc011khk.1_Missense_Mutation_p.E373Q	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	857							binding			ovary(1)	1						AAGCCTTCAAGAAAAAGCTAT	0.294													0	0	0	0.021553	0	6	78										C	89938595	G	C	89938595	3	2	67	1	0	0	0	0	1	0	0	0	2409	943	33	1	2655	1	C7orf63	7	89938595	Missense_Mutation	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08	55087186	89938595	69200068	10	20516										
KL	9365	broad.mit.edu	37	chr13	33628236	33628236	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	caacttttggaccctcacatGaagttccgccaattggaatc	7	12	1	1			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr13:33628236G>A	uc001uus.2	+	2	1160	c.1152G>A	c.(1150-1152)ATG>ATA	p.M384I	KL_uc001uur.1_Missense_Mutation_p.M77I	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	384	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACCCTCACATGAAGTTCCGCC	0.403													0	0	0	0.105934	0	11	236										A	33628236	G	A	33628236	3	1	67	1	0	0	0	0	1	0	0	0	8331	1290	45	1	1158	1	KL	13	33628236	Missense_Mutation	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08		33628236	81541642	11	20517										
ZP2	7783	broad.mit.edu	37	chr16	21210985	21210985	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	aaggcactgcagtggaagtaGacctggagacagaagagagt	15	6	0	4			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr16:21210985G>A	uc002dii.2	-	16	1833	c.1833C>T	c.(1831-1833)GTC>GTT	p.V611V	ZP2_uc010bwn.1_Silent_p.V641V	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	611	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		AGTGGAAGTAGACCTGGAGAC	0.507													0	0	0	0.150653	0	4	45										A	21210985	G	A	21210985	2	1	67	1	0	0	0	0	0	0	0	1	18213	929	33	1		1	ZP2	16	21210985	Silent	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08		21210985	69143768	12	20518										
FAM83C	128876	broad.mit.edu	37	chr20	33879832	33879832	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	gcctcctgcccctgagcctcGctgagctcagggcccccgcg	12	20	1	2	rs138645862		TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr20:33879832G>A	uc010zux.1	-	1	394	c.276C>T	c.(274-276)AGC>AGT	p.S92S	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	92										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCTGAGCCTCGCTGAGCTCAG	0.662													0	0	0	0.021553	0	6	43										A	33879832	G	A	33879832	2	1	67	1	0	0	0	0	0	0	0	1	5635	1078	38	2		2	FAM83C	20	33879832	Silent	SNP	G	TCGA-DK-A3WY-01A-11D-A22Z-08		33879832	29145688	13	20519										
GATSL3	652968	broad.mit.edu	37	chr22	30685448	30685448	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.357142857142857	5	0.0237832716028577	3	3.08571428571429	2.88	1	1	3	agaccgggacgggcgacgctCagcacccgcacccggtgttc	14	16	1	1			TCGA-DK-A3WY-01A-11D-A22Z-08	TCGA-DK-A3WY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fd5e4de-0e63-425d-a352-ecb88a9bcfbd	0f864c3a-117e-4d6b-a31f-79284943431e	g.chr22:30685448C>G	uc003ahd.2	-	1	169	c.39G>C	c.(37-39)CTG>CTC	p.L13L	GATSL3_uc003ahc.2_Silent_p.L13L|GATSL3_uc003ahe.2_Silent_p.L13L|GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|GATSL3_uc010gvr.2_5'UTR|GATSL3_uc010gvs.2_5'UTR	NM_001037666	NP_001032755	Q8WTX7	GATL3_HUMAN	GATS protein-like 3	13										breast(1)	1						GGGCGACGCTCAGCACCCGCA	0.736													0	0	0	0.115264	0	2	5										G	30685448	C	G	30685448	2	3	67	1	0	0	0	0	0	0	0	1	6265	813	29	1		1	GATSL3	22	30685448	Silent	SNP	C	TCGA-DK-A3WY-01A-11D-A22Z-08		30685448	20619118	14	20520										
ARHGEF16	27237	broad.mit.edu	37	chr1	3394482	3394482	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccggtggctgctgaagcgcgGagagctgttcttagtggaag	17	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:3394482G>C	uc001akg.3	+	11	1765	c.1517G>C	c.(1516-1518)GGA>GCA	p.G506A	ARHGEF16_uc001aki.2_Missense_Mutation_p.G218A|ARHGEF16_uc001akj.2_Missense_Mutation_p.G218A|ARHGEF16_uc010nzh.1_Missense_Mutation_p.G210A	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	506	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CTGAAGCGCGGAGAGCTGTTC	0.592													0	0	0	1	0	25	46										C	3394482	G	C	3394482	3	2	68	1	0	0	0	0	1	0	0	0	899	1174	41	1	1555	1	ARHGEF16	1	3394482	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		3394482	245856139	1	20521										
ERRFI1	54206	broad.mit.edu	37	chr1	8073944	8073944	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttcggtgggtctgaggtgGaggaggatttggatctggga	19	4	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:8073944G>C	uc001aoz.2	-	4	964	c.715C>G	c.(715-717)CCA>GCA	p.P239A	ERRFI1_uc001apa.1_Missense_Mutation_p.P164A	NM_018948	NP_061821	Q9UJM3	ERRFI_HUMAN	mitogen-inducible gene 6 protein	239					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			ovary(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		GTCTGAGGTGGAGGAGGATTT	0.468													0	0	0	1	0	6	44										C	8073944	G	C	8073944	3	2	68	1	0	0	0	0	1	0	0	0	5244	1174	41	1	677	1	ERRFI1	1	8073944	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4679462	8073944	241176677	2	20522										
RERE	473	broad.mit.edu	37	chr1	8617577	8617577	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcatgaggagatggtccctCttactctgaaaaggaaaatc	9	8	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:8617577C>G	uc001ape.2	-	6	1338	c.528G>C	c.(526-528)AAG>AAC	p.K176N	RERE_uc001apf.2_Missense_Mutation_p.K176N|RERE_uc001aph.1_Missense_Mutation_p.K176N	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	176	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GATGGTCCCTCTTACTCTGAA	0.438													0	0	0	1	0	23	59										G	8617577	C	G	8617577	3	3	68	1	0	0	0	0	1	0	0	0	13231	912	32	1	4248	1	RERE	1	8617577	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	543633	8617577	240633044	3	20523										
CTNNBIP1	56998	broad.mit.edu	37	chr1	9931317	9931317	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcataggtgcgcaggaactCctcctcgctggctgtcagct	12	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:9931317C>G	uc001aqk.1	-	5	422	c.115G>C	c.(115-117)GAG>CAG	p.E39Q	CTNNBIP1_uc001aql.1_Missense_Mutation_p.E39Q	NM_020248	NP_064633	Q9NSA3	CNBP1_HUMAN	catenin, beta interacting protein 1	39					anterior/posterior pattern formation|branching involved in ureteric bud morphogenesis|negative regulation of mesenchymal cell proliferation|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell proliferation|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway|positive regulation of monocyte differentiation|positive regulation of osteoblast differentiation|regulation of vascular permeability involved in acute inflammatory response|Wnt receptor signaling pathway	Axin-APC-beta-catenin-GSK3B complex|cytosol|nucleus	armadillo repeat domain binding|beta-catenin binding				0		all_lung(284;1.82e-05)|Lung NSC(185;3.08e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;7.32e-08)|COAD - Colon adenocarcinoma(227;1.73e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000912)|KIRC - Kidney renal clear cell carcinoma(229;0.00112)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CGCAGGAACTCCTCCTCGCTG	0.652													0	0	0	1	0	2	2										G	9931317	C	G	9931317	3	3	68	1	0	0	0	0	1	0	0	0	4017	864	30	1	138	1	CTNNBIP1	1	9931317	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1313740	9931317	239319304	4	20524										
C1orf127	148345	broad.mit.edu	37	chr1	11008292	11008292	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgccccctggccccctcccTggggagaccaggccctgtct	12	19	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:11008292T>C	uc010oao.1	-	8	1458	c.1453A>G	c.(1453-1455)AGG>GGG	p.R485G	C1orf127_uc001arr.1_Missense_Mutation_p.R467G|C1orf127_uc001ars.1_Missense_Mutation_p.R459G	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	485										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GCCCCCTCCCTGGGGAGACCA	0.637													0	0	0	1	0	21	76										C	11008292	T	C	11008292	3	2	68	1	0	0	0	0	1	0	0	0	1994	1579	55	5	575	5	C1orf127	1	11008292	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	1076975	11008292	238242329	5	20525										
TARDBP	23435	broad.mit.edu	37	chr1	11082329	11082329	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggctttgggaatcagggtgGatttggtaatagcagagggg	18	3	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:11082329G>A	uc001art.2	+	6	997	c.863G>A	c.(862-864)GGA>GAA	p.G288E	TARDBP_uc010oap.1_Missense_Mutation_p.G172E	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	288	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AATCAGGGTGGATTTGGTAAT	0.453													0	0	0	1	0	14	73										A	11082329	G	A	11082329	3	1	68	1	0	0	0	0	1	0	0	0	15554	1174	41	1	881	1	TARDBP	1	11082329	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	74037	11082329	238168292	6	20526										
TARDBP	23435	broad.mit.edu	37	chr1	11082344	11082344	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggtggatttggtaatagcaGagggggtggagctggtttgg	21	2	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:11082344G>C	uc001art.2	+	6	1012	c.878G>C	c.(877-879)AGA>ACA	p.R293T	TARDBP_uc010oap.1_Missense_Mutation_p.R177T	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	293	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GGTAATAGCAGAGGGGGTGGA	0.483													0	0	0	1	0	11	71										C	11082344	G	C	11082344	3	2	68	1	0	0	0	0	1	0	0	0	15554	942	33	1	896	1	TARDBP	1	11082344	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	15	11082344	238168277	7	20527										
CLCN6	1185	broad.mit.edu	37	chr1	11900229	11900229	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcatcacacggcacaacctCacctatgaatttctgcaggc	6	14	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:11900229C>T	uc001ate.3	+	23	2672	c.2559C>T	c.(2557-2559)CTC>CTT	p.L853L	CLCN6_uc010oat.1_Silent_p.L569L|CLCN6_uc010oau.1_Silent_p.L831L|CLCN6_uc010oav.1_5'Flank|CLCN6_uc010oaw.1_5'Flank|CLCN6_uc010oax.1_5'Flank|CLCN6_uc010oay.1_5'Flank|CLCN6_uc010oaz.1_5'Flank|CLCN6_uc010oba.1_5'Flank	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	853	CBS 2.|Cytoplasmic (By similarity).				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GGCACAACCTCACCTATGAAT	0.587													0	0	0	1	0	39	88										T	11900229	C	T	11900229	2	4	68	1	0	0	0	0	0	0	0	1	3467	813	29	1		1	CLCN6	1	11900229	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	817885	11900229	237350392	8	20528										
VPS13D	55187	broad.mit.edu	37	chr1	12446370	12446370	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcaaccagtcacatgcttGaactcagcatacaggatgta	9	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:12446370G>A	uc001atv.2	+	60	11752	c.11611G>A	c.(11611-11613)GAA>AAA	p.E3871K	VPS13D_uc001atw.2_Missense_Mutation_p.E3846K|VPS13D_uc001atx.2_Missense_Mutation_p.E3058K|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3870					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCACATGCTTGAACTCAGCAT	0.428													0	0	0	1	0	46	93										A	12446370	G	A	12446370	3	1	68	1	0	0	0	0	1	0	0	0	17189	1291	45	1	11845	1	VPS13D	1	12446370	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	546141	12446370	236804251	9	20529										
PRAMEF12	390999	broad.mit.edu	37	chr1	12836179	12836179	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgtcatccagttcacctctCagttcctcaagctggactac	6	14	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:12836179C>T	uc001aui.2	+	2	808	c.781C>T	c.(781-783)CAG>TAG	p.Q261*		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	261										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTTCACCTCTCAGTTCCTCAA	0.507													0	0	0	1	0	51	127										T	12836179	C	T	12836179	4	4	68	1	0	0	0	0	0	1	0	0	12428	827	29	1	787	1	PRAMEF12	1	12836179	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	389809	12836179	236414442	10	20530										
PRAMEF11	440560	broad.mit.edu	37	chr1	12885303	12885303	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgggagagatgcttcaagtCtgattccaaaagcacacagt	10	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:12885303C>T	uc001auk.2	-	4	1004	c.808G>A	c.(808-810)GAC>AAC	p.D270N		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	270	LRR 3.										0						TGCTTCAAGTCTGATTCCAAA	0.468													0	0	0	1	0	114	300										T	12885303	C	T	12885303	3	4	68	1	0	0	0	0	1	0	0	0	12427	913	32	1	506	1	PRAMEF11	1	12885303	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	49124	12885303	236365318	11	20531										
EPHA2	1969	broad.mit.edu	37	chr1	16459790	16459790	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgtagccggctttcagcgtCttgatggccaccggcacctc	12	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:16459790C>G	uc001aya.1	-	11	2075	c.1938G>C	c.(1936-1938)AAG>AAC	p.K646N		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	646	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).	ATP (By similarity).			activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTTTCAGCGTCTTGATGGCCA	0.607													0	0	0	1	0	9	84										G	16459790	C	G	16459790	3	3	68	1	0	0	0	0	1	0	0	0	5167	912	32	1	1020	1	EPHA2	1	16459790	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3574487	16459790	232790831	12	20532										
FBXO42	54455	broad.mit.edu	37	chr1	16641900	16641900	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aactgtcatcttcactgtccGaggagctggccatgacattc	9	12	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:16641900G>A	uc001ayg.2	-	2	230	c.14C>T	c.(13-15)TCA>TTA	p.S5L	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.S5L	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	5										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		TTCACTGTCCGAGGAGCTGGC	0.458													0	0	0	1	0	8	55										A	16641900	G	A	16641900	3	1	68	1	0	0	0	0	1	0	0	0	5751	1059	37	1	2175	1	FBXO42	1	16641900	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	182110	16641900	232608721	13	20533										
KLHDC7A	127707	broad.mit.edu	37	chr1	18808297	18808297	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtccgaatggaggagcatttCatacagaaggcggagggggt	17	6	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:18808297C>T	uc001bax.2	+	1	874	c.822C>T	c.(820-822)TTC>TTT	p.F274F	KLHDC7A_uc009vpg.2_Silent_p.F56F	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	274						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGCATTTCATACAGAAGG	0.592													0	0	0	1	0	21	133										T	18808297	C	T	18808297	2	4	68	1	0	0	0	0	0	0	0	1	8360	825	29	1		1	KLHDC7A	1	18808297	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2166397	18808297	230442324	14	20534										
SH2D5	400745	broad.mit.edu	37	chr1	21048338	21048338	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcatggctgaggggccggaGagtccggggcggcctgcctg	21	11	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:21048338G>A	uc001bdt.1	-	9	1592	c.967C>T	c.(967-969)CTC>TTC	p.L323F	SH2D5_uc009vpy.1_Missense_Mutation_p.L407F|SH2D5_uc001bdu.1_RNA	NM_001103160	NP_001096630	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5 isoform 2	323											0		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AGGGGCCGGAGAGTCCGGGGC	0.701													0	0	0	1	0	5	22										A	21048338	G	A	21048338	3	1	68	1	0	0	0	0	1	0	0	0	14237	942	33	1	56	1	SH2D5	1	21048338	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2240041	21048338	228202283	15	20535										
HSPG2	3339	broad.mit.edu	37	chr1	22157765	22157765	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgccgtgcgccgtgaggttGaggtcatggaagacgatctc	15	9	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:22157765G>A	uc001bfj.2	-	84	11545	c.11505C>T	c.(11503-11505)CTC>CTT	p.L3835L	HSPG2_uc001bfi.2_5'Flank|HSPG2_uc009vqd.2_Silent_p.L3836L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3835	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCGTGAGGTTGAGGTCATGGA	0.687													0	0	0	1	0	11	73										A	22157765	G	A	22157765	2	1	68	1	0	0	0	0	0	0	0	1	7430	1277	45	1		1	HSPG2	1	22157765	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1109427	22157765	227092856	16	20536										
CELA3A	10136	broad.mit.edu	37	chr1	22333440	22333440	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccgtccagctcgcctcactCcctcccgctggtgacatcct	8	20	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:22333440C>A	uc001bfl.2	+	5	451	c.432C>A	c.(430-432)CTC>CTA	p.L144L		NM_005747	NP_005738	P09093	CEL3A_HUMAN	elastase 3A, pancreatic preproprotein	144	Peptidase S1.				cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1						TCGCCTCACTCCCTCCCGCTG	0.617													1	0	0.00185496	1	0.00189251	14	95										A	22333440	C	A	22333440	2	1	68	1	0	0	0	0	0	0	0	1	3213	842	30	3		3	CELA3A	1	22333440	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	175675	22333440	226917181	17	20537										
LUZP1	7798	broad.mit.edu	37	chr1	23418777	23418777	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgctatgtccaagtcatcatCtgagtctggcttctctctgc	8	12	6	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:23418777C>T	uc001bgk.2	-	4	2362	c.1978G>A	c.(1978-1980)GAT>AAT	p.D660N	LUZP1_uc010odv.1_Missense_Mutation_p.D660N|LUZP1_uc001bgl.2_Missense_Mutation_p.D660N|LUZP1_uc001bgm.1_Missense_Mutation_p.D660N	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	660						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		AAGTCATCATCTGAGTCTGGC	0.478													0	0	0	1	0	79	157										T	23418777	C	T	23418777	3	4	68	1	0	0	0	0	1	0	0	0	9086	913	32	1	1260	1	LUZP1	1	23418777	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1085337	23418777	225831844	18	20538										
CNR2	1269	broad.mit.edu	37	chr1	24201129	24201129	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggggcttcttcttttgcctCtgacccaaggcccctcacac	8	17	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:24201129C>A	uc001bif.2	-	2	1106	c.979G>T	c.(979-981)GAG>TAG	p.E327*		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	327	Cytoplasmic (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TCTTTTGCCTCTGACCCAAGG	0.552													1	0	0.000308642	1	0.0003185	9	105										A	24201129	C	A	24201129	4	1	68	1	0	0	0	0	0	1	0	0	3632	922	32	3	107	3	CNR2	1	24201129	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	782352	24201129	225049492	19	20539										
RHCE	6006	broad.mit.edu	37	chr1	25717274	25717274	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgggggtgagccaaggatGaccctgagatggctgtcacc	15	9	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:25717274G>A	uc001bkf.2	-	5	853	c.767C>T	c.(766-768)TCA>TTA	p.S256L	RHCE_uc001bkg.2_Missense_Mutation_p.S256L|RHCE_uc001bkh.2_Intron|RHCE_uc001bki.2_Intron|RHCE_uc001bkj.2_Missense_Mutation_p.S240L	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	256	Helical; (Potential).					integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AGCCAAGGATGACCCTGAGAT	0.527													0	0	0	1	0	21	141										A	25717274	G	A	25717274	3	1	68	1	0	0	0	0	1	0	0	0	13325	1294	45	1	510	1	RHCE	1	25717274	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1516145	25717274	223533347	20	20540										
MAN1C1	57134	broad.mit.edu	37	chr1	25944772	25944772	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggtcctgggaacgagggccGatgagagtcaggagccccag	17	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:25944772G>A	uc001bkm.2	+	1	814	c.484G>A	c.(484-486)GAT>AAT	p.D162N	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	162	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		AACGAGGGCCGATGAGAGTCA	0.652													0	0	0	1	0	5	15										A	25944772	G	A	25944772	3	1	68	1	0	0	0	0	1	0	0	0	9213	1058	37	1	486	1	MAN1C1	1	25944772	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	227498	25944772	223305849	21	20541										
CNKSR1	10256	broad.mit.edu	37	chr1	26507029	26507029	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagctctgcccccaaagcctCgaggctctggctgtgcggtc	12	16	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:26507029C>T	uc001bln.3	+	2	196	c.138C>T	c.(136-138)CTC>CTT	p.L46L	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Silent_p.L46L|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	46	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAAAGCCTCGAGGCTCTGG	0.622													0	0	0	1	0	28	66										T	26507029	C	T	26507029	2	4	68	1	0	0	0	0	0	0	0	1	3606	871	31	1		1	CNKSR1	1	26507029	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	562257	26507029	222743592	22	20542										
AIM1L	55057	broad.mit.edu	37	chr1	26650797	26650797	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccagaggcggaaataaaccCggcgctggtggcagaaagag	15	9	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:26650797C>A	uc001bmd.3	-	17	1878	c.1448G>T	c.(1447-1449)CGG>CTG	p.R483L		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	483							sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		GAAATAAACCCGGCGCTGGTG	0.637													1	0	0.00909568	1	0.00919788	4	25										A	26650797	C	A	26650797	3	1	68	1	0	0	0	0	1	0	0	0	431	652	23	4	414	4	AIM1L	1	26650797	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	143768	26650797	222599824	23	20543										
PTAFR	5724	broad.mit.edu	37	chr1	28477356	28477356	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagagcatgtccgccatggtGaggttcaccatgaagatctt	11	9	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:28477356G>A	uc001bpl.2	-	2	304	c.177C>T	c.(175-177)CTC>CTT	p.L59L	PTAFR_uc001bpm.3_Silent_p.L59L|PTAFR_uc009vte.2_Silent_p.L59L	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	59	Helical; Name=2; (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CCGCCATGGTGAGGTTCACCA	0.498													0	0	0	1	0	5	59										A	28477356	G	A	28477356	2	1	68	1	0	0	0	0	0	0	0	1	12723	1277	45	1		1	PTAFR	1	28477356	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1826559	28477356	220773265	24	20544										
MECR	51102	broad.mit.edu	37	chr1	29528545	29528545	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcagtctgtcactcagcttCtggatatcaggtctggaaac	9	10	7	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:29528545C>A	uc001brq.1	-	6	702	c.666G>T	c.(664-666)CAG>CAT	p.Q222H	MECR_uc001brp.1_Missense_Mutation_p.Q146H|MECR_uc001brr.1_Missense_Mutation_p.Q146H|MECR_uc001brs.1_RNA|MECR_uc001brt.1_Missense_Mutation_p.Q146H|MECR_uc010ofz.1_Missense_Mutation_p.Q222H	NM_016011	NP_057095	Q9BV79	MECR_HUMAN	trans-2-enoyl-CoA reductase, mitochondrial	222					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		CACTCAGCTTCTGGATATCAG	0.512													1	0	3.66258e-25	1	4.23381e-25	78	217										A	29528545	C	A	29528545	3	1	68	1	0	0	0	0	1	0	0	0	9424	912	32	3	475	3	MECR	1	29528545	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1051189	29528545	219722076	25	20545										
TXLNA	200081	broad.mit.edu	37	chr1	32660659	32660659	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccctcactgacagtggccctGagaggaggccagaggggcct	15	13	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:32660659G>A	uc001bui.2	+	11	1569	c.1504G>A	c.(1504-1506)GAG>AAG	p.E502K	TXLNA_uc001buj.2_Missense_Mutation_p.E502K	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	502					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CAGTGGCCCTGAGAGGAGGCC	0.642													0	0	0	1	0	23	26										A	32660659	G	A	32660659	3	1	68	1	0	0	0	0	1	0	0	0	16784	1291	45	1	1542	1	TXLNA	1	32660659	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3132114	32660659	216589962	26	20546										
YARS	8565	broad.mit.edu	37	chr1	33245727	33245727	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttgggactcgactcctctCatcttctggggtttcaggtt	10	12	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:33245727C>A	uc001bvy.1	-	11	2081	c.1293G>T	c.(1291-1293)ATG>ATT	p.M431I	YARS_uc001bvw.1_Missense_Mutation_p.M91I|YARS_uc001bvx.1_Missense_Mutation_p.M82I	NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	431	tRNA-binding.				apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	CGACTCCTCTCATCTTCTGGG	0.577													1	0	0.00152264	1	0.00155472	22	140										A	33245727	C	A	33245727	3	1	68	1	0	0	0	0	1	0	0	0	17464	826	29	3	305	3	YARS	1	33245727	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	585068	33245727	216004894	27	20547										
CSMD2	114784	broad.mit.edu	37	chr1	34034982	34034982	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggtcacttaccaaggcagCggacttcagagccactccag	11	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:34034982C>G	uc001bxn.1	-	53	8158	c.8129G>C	c.(8128-8130)CGC>CCC	p.R2710P	CSMD2_uc001bxm.1_Missense_Mutation_p.R2708P	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2710	Sushi 17.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCAAGGCAGCGGACTTCAGA	0.522													0	0	0	1	0	11	44										G	34034982	C	G	34034982	3	3	68	1	0	0	0	0	1	0	0	0	3945	768	27	4	2402	4	CSMD2	1	34034982	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	789255	34034982	215215639	28	20548										
ZMYM1	79830	broad.mit.edu	37	chr1	35579630	35579630	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aataaaatagcagcagaattCaagaaagaagaaccaagagc	8	6	1	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:35579630C>G	uc001bym.2	+	11	2347	c.2199C>G	c.(2197-2199)TTC>TTG	p.F733L	ZMYM1_uc001byn.2_Missense_Mutation_p.F733L|ZMYM1_uc010ohu.1_Missense_Mutation_p.F714L|ZMYM1_uc001byo.2_Missense_Mutation_p.F373L|ZMYM1_uc009vut.2_Missense_Mutation_p.F658L	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	733						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGCAGAATTCAAGAAAGAAG	0.318													0	0	0	1	0	15	51										G	35579630	C	G	35579630	3	3	68	1	0	0	0	0	1	0	0	0	17696	825	29	1	2233	1	ZMYM1	1	35579630	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1544648	35579630	213670991	29	20549										
TEKT2	27285	broad.mit.edu	37	chr1	36550615	36550615	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccaccaatgcccagctgcaGcgagatgcttcccatcagat	8	15	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:36550615G>C	uc001bzr.2	+	2	220	c.93G>C	c.(91-93)CAG>CAC	p.Q31H	TEKT2_uc001bzs.2_5'UTR	NM_014466	NP_055281	Q9UIF3	TEKT2_HUMAN	tektin 2	31					cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCCAGCTGCAGCGAGATGCTT	0.617													0	0	0	1	0	9	64										C	36550615	G	C	36550615	3	2	68	1	0	0	0	0	1	0	0	0	15750	962	34	4	95	4	TEKT2	1	36550615	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	970985	36550615	212700006	30	20550										
THRAP3	9967	broad.mit.edu	37	chr1	36766618	36766618	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caccacgggctttgacaaatCaagactggggaccaaagact	10	11	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:36766618C>G	uc001cae.3	+	10	2659	c.2435C>G	c.(2434-2436)TCA>TGA	p.S812*	THRAP3_uc001caf.3_Nonsense_Mutation_p.S812*	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	812					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTTGACAAATCAAGACTGGGG	0.517			T	USP6	aneurysmal bone cysts								0	0	0	1	0	5	46										G	36766618	C	G	36766618	4	3	68	1	0	0	0	0	0	1	0	0	15871	838	29	1	2465	1	THRAP3	1	36766618	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	216003	36766618	212484003	31	20551										
CSF3R	1441	broad.mit.edu	37	chr1	36933439	36933439	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttacctggggtcaaggtcatCagggtgaggactgtactgtt	14	7	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:36933439C>T	uc001caw.1	-	14	2026	c.1848G>A	c.(1846-1848)CTG>CTA	p.L616L	CSF3R_uc001cat.1_Silent_p.L179L|CSF3R_uc009vvc.1_Silent_p.L145L|CSF3R_uc001cau.1_Silent_p.L16L|CSF3R_uc001cav.1_Silent_p.L616L|CSF3R_uc001cax.1_Silent_p.L616L|CSF3R_uc001cay.1_Silent_p.L616L	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	616	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TCAAGGTCATCAGGGTGAGGA	0.602													0	0	0	1	0	20	81										T	36933439	C	T	36933439	2	4	68	1	0	0	0	0	0	0	0	1	3937	813	29	1		1	CSF3R	1	36933439	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	166821	36933439	212317182	32	20552										
GNL2	29889	broad.mit.edu	37	chr1	38040350	38040350	+	Silent	SNP	G	G	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcaatcttgtatgttttgctGatatattctggctttgctcg							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:38040350G>T	uc001cbk.2	-	11	1381	c.1218C>A	c.(1216-1218)ATC>ATA	p.I406I		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	406					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				ATGTTTTGCTGATATATTCTG	0.413													1	0	0.000673444	1	0.000690993	9	46										T	38040350	G	T	38040350	2	4	68	1	0	0	0	0	0	0	0	1	6536	1280	45	3		3	GNL2	1	38040350	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1106911	38040350	211210271	33	20553	103	2								
GNL2	29889	broad.mit.edu	37	chr1	38040358	38040358	+	Nonsense_Mutation	SNP	C	C	A													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtatgttttgctgatatattCtggctttgctcgttcaagta							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:38040358C>A	uc001cbk.2	-	11	1373	c.1210G>T	c.(1210-1212)GAA>TAA	p.E404*		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	404					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				CTGATATATTCTGGCTTTGCT	0.403													1	0	1.58986e-06	1	1.6848e-06	9	51										A	38040358	C	A	38040358	4	1	68	1	0	0	0	0	0	1	0	0	6536	922	32	3	1009	3	GNL2	1	38040358	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	8	38040358	211210263	34	20554	103	2								
RHBDL2	54933	broad.mit.edu	37	chr1	39384788	39384788	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgatctttacctcccccatCctctctcattttctcctctt	1	19	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:39384788C>T	uc001ccu.1	-	2	325	c.97G>A	c.(97-99)GAT>AAT	p.D33N	RHBDL2_uc010oin.1_Missense_Mutation_p.D33N|RHBDL2_uc010oio.1_Missense_Mutation_p.D113N|RHBDL2_uc001ccv.2_Missense_Mutation_p.D33N	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	33					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CCTCCCCCATCCTCTCTCATT	0.483													0	0	0	1	0	26	109										T	39384788	C	T	39384788	3	4	68	1	0	0	0	0	1	0	0	0	13322	855	30	1	842	1	RHBDL2	1	39384788	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1344430	39384788	209865833	35	20555										
KIAA0754	643314	broad.mit.edu	37	chr1	39876688	39876688	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtaacacagatgtaatgcagGaatccagattctcaagtgca	9	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:39876688G>A	uc009vvt.1	+	1	1513	c.751G>A	c.(751-753)GAA>AAA	p.E251K	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	115											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTAATGCAGGAATCCAGATT	0.502											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	37										A	39876688	G	A	39876688	3	1	68	1	0	0	0	0	1	0	0	0	8192	1175	41	1	753	1	KIAA0754	1	39876688	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	491900	39876688	209373933	36	20556										
HPCAL4	51440	broad.mit.edu	37	chr1	40149690	40149690	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcaaaggcccagttgagcttCtgctcgaagctgccgcggga	13	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:40149690C>T	uc001cdr.2	-	3	417	c.297G>A	c.(295-297)CAG>CAA	p.Q99Q	HPCAL4_uc010oix.1_Intron	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	99	EF-hand 3.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AGTTGAGCTTCTGCTCGAAGC	0.657													0	0	0	1	0	13	47										T	40149690	C	T	40149690	2	4	68	1	0	0	0	0	0	0	0	1	7331	912	32	1		1	HPCAL4	1	40149690	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	273002	40149690	209100931	37	20557										
TRIT1	54802	broad.mit.edu	37	chr1	40323037	40323037	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcatgtggtgccggcagattCtctgctcttgggcagaaacc	12	11	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:40323037C>G	uc010oiz.1	-	2	241	c.227G>C	c.(226-228)AGA>ACA	p.R76T	TRIT1_uc001ceq.2_Intron|TRIT1_uc001cek.2_Intron|TRIT1_uc009vvx.2_Intron|TRIT1_uc001cel.2_Intron|TRIT1_uc001cem.2_Intron|TRIT1_uc001cen.2_Intron|TRIT1_uc001ceo.2_Intron|TRIT1_uc001cep.2_Intron	NM_017646	NP_060116	Q9H3H1	MOD5_HUMAN	tRNA isopentenyltransferase 1 precursor	76					tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CCGGCAGATTCTCTGCTCTTG	0.448													0	0	0	1	0	6	28										G	40323037	C	G	40323037	3	3	68	1	0	0	0	0	1	0	0	0	16557	913	32	1	1216	1	TRIT1	1	40323037	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	173347	40323037	208927584	38	20558										
PPCS	79717	broad.mit.edu	37	chr1	42922574	42922574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccttcgggcccagccctttCgggcttgctgagcctggagg	15	14	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:42922574C>T	uc001chl.2	+	1	402	c.338C>T	c.(337-339)TCG>TTG	p.S113L	ZMYND12_uc001chj.2_5'Flank|ZMYND12_uc010ojt.1_5'Flank|PPCS_uc001chk.2_Intron	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	113					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCAGCCCTTTCGGGCTTGCTG	0.647													0	0	0	1	0	20	87										T	42922574	C	T	42922574	3	4	68	1	0	0	0	0	1	0	0	0	12305	893	31	1	340	1	PPCS	1	42922574	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2599537	42922574	206328047	39	20559										
KIAA0467	23334	broad.mit.edu	37	chr1	43908528	43908528	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgccgaccatggaagtggaGaccctcatccggagtgcaag	13	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:43908528G>C	uc001cjk.1	+	44	5955	c.5493G>C	c.(5491-5493)GAG>GAC	p.E1831D		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2730						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGAAGTGGAGACCCTCATCC	0.612													0	0	0	1	0	25	112										C	43908528	G	C	43908528	3	2	68	1	0	0	0	0	1	0	0	0	8178	933	33	1	5659	1	KIAA0467	1	43908528	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	985954	43908528	205342093	40	20560										
TMEM53	79639	broad.mit.edu	37	chr1	45140082	45140082	+	Translation_Start_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atggtgaaggcgccggcccaGagcacgggtctccagccgga	16	13	1	2	rs114472931	by1000genomes	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:45140082G>T	uc001cmc.2	-	1	18	c.-18C>A	c.(-20--16)CTCTG>CTATG		TMEM53_uc001cmb.1_Translation_Start_Site|TMEM53_uc001cmd.2_Translation_Start_Site|TMEM53_uc009vxh.1_5'Flank|C1orf228_uc001cmf.2_5'Flank	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53							integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					CGCCGGCCCAGAGCACGGGTC	0.682													1	0	0.00909568	1	0.00919788	4	20										T	45140082	G	T	45140082	1	4	68	1	0	0	0	0	0	0	0	0	16176	957	33	3		3	TMEM53	1	45140082	Translation_Start_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1231554	45140082	204110539	41	20561										
TMEM69	51249	broad.mit.edu	37	chr1	46159475	46159475	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccaactggtttaaagccctGaggatagtagtcactttatt	8	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:46159475G>T	uc001cor.1	+	3	838	c.642G>T	c.(640-642)CTG>CTT	p.L214L		NM_016486	NP_057570	Q5SWH9	TMM69_HUMAN	transmembrane protein 69	214						integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TTAAAGCCCTGAGGATAGTAG	0.368													1	0	3.51602e-12	1	3.95199e-12	20	71										T	46159475	G	T	46159475	2	4	68	1	0	0	0	0	0	0	0	1	16195	1277	45	3		3	TMEM69	1	46159475	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1019393	46159475	203091146	42	20562										
C1orf190	541468	broad.mit.edu	37	chr1	46669164	46669164	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagggtaaggtgggcaggaaGacccctgaagggctgctccg	18	9	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:46669164G>C	uc010oma.1	+	1	159	c.66G>C	c.(64-66)AAG>AAC	p.K22N	POMGNT1_uc001cpg.2_Intron|POMGNT1_uc001cpf.2_Intron	NM_001013615	NP_001013633	Q96LR2	CA190_HUMAN	hypothetical protein LOC541468	22					positive regulation of cytokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm				ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(166;0.155)					TGGGCAGGAAGACCCCTGAAG	0.692													0	0	0	1	0	7	46										C	46669164	G	C	46669164	3	2	68	1	0	0	0	0	1	0	0	0	2023	933	33	1	68	1	C1orf190	1	46669164	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	509689	46669164	202581457	43	20563										
LRRC41	10489	broad.mit.edu	37	chr1	46768814	46768814	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accccacaccccgctctccaGaacccccatatgggcgctca	6	21	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:46768814G>A	uc001cpn.2	-	1	225	c.181C>T	c.(181-183)CTG>TTG	p.L61L	LRRC41_uc010omb.1_Silent_p.L61L|LRRC41_uc001cpo.1_Silent_p.L61L|UQCRH_uc001cpp.2_5'Flank|UQCRH_uc001cpq.2_5'Flank	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	61										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CCGCTCTCCAGAACCCCCATA	0.567													0	0	0	1	0	3	3										A	46768814	G	A	46768814	2	1	68	1	0	0	0	0	0	0	0	1	8999	933	33	1		1	LRRC41	1	46768814	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	99650	46768814	202481807	44	20564										
CYP4B1	1580	broad.mit.edu	37	chr1	47284418	47284418	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcccatcaagatgccccagCttgtcctgcgctccaagaat	8	15	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:47284418C>T	uc001cqm.3	+	12	1552	c.1468C>T	c.(1468-1470)CTT>TTT	p.L490F	CYP4B1_uc001cqn.3_Missense_Mutation_p.L491F|CYP4B1_uc009vym.2_Missense_Mutation_p.L476F|CYP4B1_uc010omk.1_Missense_Mutation_p.L327F	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	490					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GATGCCCCAGCTTGTCCTGCG	0.577													0	0	0	1	0	27	96										T	47284418	C	T	47284418	3	4	68	1	0	0	0	0	1	0	0	0	4185	797	28	2	1517	2	CYP4B1	1	47284418	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	515604	47284418	201966203	45	20565										
EPS15	2060	broad.mit.edu	37	chr1	51934202	51934202	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtgaaacttccaatccattCtgggcacatgccacaagacg	8	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:51934202C>T	uc001csq.1	-	5	344	c.252G>A	c.(250-252)CAG>CAA	p.Q84Q	EPS15_uc009vyz.1_Silent_p.Q84Q	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	84	EH 1.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						CCAATCCATTCTGGGCACATG	0.358			T	MLL	ALL								0	0	0	1	0	9	53										T	51934202	C	T	51934202	2	4	68	1	0	0	0	0	0	0	0	1	5192	912	32	1		1	EPS15	1	51934202	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4649784	51934202	197316419	46	20566										
ZCCHC11	23318	broad.mit.edu	37	chr1	52940569	52940569	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgggtggggaggttatcatCatcattaaggtcagaagcat	13	6	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:52940569C>A	uc001ctx.2	-	13	2896	c.2662G>T	c.(2662-2664)GAT>TAT	p.D888Y	ZCCHC11_uc001cty.2_Missense_Mutation_p.D888Y|ZCCHC11_uc001ctz.2_Missense_Mutation_p.D888Y|ZCCHC11_uc009vze.1_Missense_Mutation_p.D888Y|ZCCHC11_uc009vzf.1_Missense_Mutation_p.D647Y|ZCCHC11_uc001cub.2_Missense_Mutation_p.D888Y	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	888					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AGGTTATCATCATCATTAAGG	0.378													1	0	1.7881e-09	1	1.96769e-09	29	45										A	52940569	C	A	52940569	3	1	68	1	0	0	0	0	1	0	0	0	17577	826	29	3	2347	3	ZCCHC11	1	52940569	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1006367	52940569	196310052	47	20567										
ZCCHC11	23318	broad.mit.edu	37	chr1	52940929	52940929	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtgatgtacagtccatttCatcacattgaacaggttgct	8	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:52940929C>T	uc001ctx.2	-	13	2536	c.2302G>A	c.(2302-2304)GAA>AAA	p.E768K	ZCCHC11_uc001cty.2_Missense_Mutation_p.E768K|ZCCHC11_uc001ctz.2_Missense_Mutation_p.E768K|ZCCHC11_uc009vze.1_Missense_Mutation_p.E768K|ZCCHC11_uc009vzf.1_Missense_Mutation_p.E527K|ZCCHC11_uc001cub.2_Missense_Mutation_p.E768K	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	768					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						CAGTCCATTTCATCACATTGA	0.388													0	0	0	1	0	45	102										T	52940929	C	T	52940929	3	4	68	1	0	0	0	0	1	0	0	0	17577	835	29	1	2707	1	ZCCHC11	1	52940929	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	360	52940929	196309692	48	20568										
ZCCHC11	23318	broad.mit.edu	37	chr1	52941053	52941053	+	Missense_Mutation	SNP	C	C	G													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttattgcttattttccccttCtctcttttcttgaaatccac							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:52941053C>G	uc001ctx.2	-	13	2412	c.2178G>C	c.(2176-2178)GAG>GAC	p.E726D	ZCCHC11_uc001cty.2_Missense_Mutation_p.E726D|ZCCHC11_uc001ctz.2_Missense_Mutation_p.E726D|ZCCHC11_uc009vze.1_Missense_Mutation_p.E726D|ZCCHC11_uc009vzf.1_Missense_Mutation_p.E485D|ZCCHC11_uc001cub.2_Missense_Mutation_p.E726D	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	726					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTTCCCCTTCTCTCTTTTCT	0.398													0	0	0	1	0	40	116										G	52941053	C	G	52941053	3	3	68	1	0	0	0	0	1	0	0	0	17577	912	32	1	2831	1	ZCCHC11	1	52941053	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	124	52941053	196309568	49	20569	104	2								
ZCCHC11	23318	broad.mit.edu	37	chr1	52941062	52941062	+	Silent	SNP	C	C	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attttccccttctctcttttCttgaaatccactgtagactt							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:52941062C>T	uc001ctx.2	-	13	2403	c.2169G>A	c.(2167-2169)AAG>AAA	p.K723K	ZCCHC11_uc001cty.2_Silent_p.K723K|ZCCHC11_uc001ctz.2_Silent_p.K723K|ZCCHC11_uc009vze.1_Silent_p.K723K|ZCCHC11_uc009vzf.1_Silent_p.K482K|ZCCHC11_uc001cub.2_Silent_p.K723K	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	723					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						TCTCTCTTTTCTTGAAATCCA	0.403													0	0	0	1	0	39	110										T	52941062	C	T	52941062	2	4	68	1	0	0	0	0	0	0	0	1	17577	912	32	1		1	ZCCHC11	1	52941062	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9	52941062	196309559	50	20570	104	2								
YIPF1	54432	broad.mit.edu	37	chr1	54348950	54348950	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtggctgcattgccaaattCtgaaatcaattagagcacac	8	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:54348950C>T	uc001cvu.2	-	4	369	c.32_splice	c.e4-1	p.E11_splice	YIPF1_uc001cvv.2_Splice_Site|YIPF1_uc001cvw.2_Intron|YIPF1_uc001cvx.2_Splice_Site|YIPF1_uc001cvy.2_Splice_Site	NM_018982	NP_061855	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1							integral to membrane|transport vesicle				large_intestine(1)|ovary(1)	2						TTGCCAAATTCTGAAATCAAT	0.453													0	0	0	1	0	7	34										T	54348950	C	T	54348950	5	4	68	1	0	0	0	0	0	0	1	0	17474	927	32	1	917	1	YIPF1	1	54348950	Splice_Site	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1407888	54348950	194901671	51	20571										
DIO1	1733	broad.mit.edu	37	chr1	54359913	54359913	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccccagccagggctgtggctGaagaggctctgggtgctctt	15	12	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:54359913G>A	uc010onx.1	+	1	53	c.30G>A	c.(28-30)CTG>CTA	p.L10L	DIO1_uc010onw.1_Silent_p.L10L|DIO1_uc009vzl.2_Silent_p.L10L|DIO1_uc001cwb.2_Silent_p.L10L|DIO1_uc010ony.1_Silent_p.L10L|DIO1_uc001cwd.2_RNA|DIO1_uc001cwe.2_RNA|DIO1_uc001cwf.2_RNA|DIO1_uc001cwg.2_RNA	NM_000792	NP_000783	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I isoform a	10					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity				0						GGCTGTGGCTGAAGAGGCTCT	0.587													0	0	0	1	0	12	48										A	54359913	G	A	54359913	2	1	68	1	0	0	0	0	0	0	0	1	4524	1277	45	1		1	DIO1	1	54359913	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10963	54359913	194890708	52	20572										
TTC22	55001	broad.mit.edu	37	chr1	55266753	55266753	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggctcgaagttcaactgcatCtccaggtgaaagtggcccgg	13	11	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:55266753C>T	uc009vzt.1	-	1	189	c.84G>A	c.(82-84)GAG>GAA	p.E28E	TTC22_uc001cxz.3_Silent_p.E28E	NM_001114108	NP_001107580	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22 isoform 1	28							binding				0						TCAACTGCATCTCCAGGTGAA	0.687													0	0	0	1	0	9	25										T	55266753	C	T	55266753	2	4	68	1	0	0	0	0	0	0	0	1	16686	912	32	1		1	TTC22	1	55266753	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	906840	55266753	193983868	53	20573										
JUN	3725	broad.mit.edu	37	chr1	59248200	59248200	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcgccccgccgccgctgctCagcgcgcctgggttgaagtt	15	16	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:59248200C>T	uc001cze.2	-	1	1586	c.543G>A	c.(541-543)CTG>CTA	p.L181L	uc001czf.2_5'Flank|uc010oop.1_5'Flank	NM_002228	NP_002219	P05412	JUN_HUMAN	jun oncogene	181					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding				0	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)	CGCCGCTGCTCAGCGCGCCTG	0.746			A		sarcoma								0	0	0	1	0	3	5										T	59248200	C	T	59248200	2	4	68	1	0	0	0	0	0	0	0	1	7969	813	29	1		1	JUN	1	59248200	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3981447	59248200	190002421	54	20574										
DOCK7	85440	broad.mit.edu	37	chr1	63003725	63003725	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcggtaatgagtaaagctttGaagacaccttgtaagcaatg	10	6	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:63003725G>A	uc001daq.2	-	28	3342	c.3308C>T	c.(3307-3309)TCA>TTA	p.S1103L	DOCK7_uc001dan.2_Missense_Mutation_p.S964L|DOCK7_uc001dao.2_Missense_Mutation_p.S964L|DOCK7_uc001dap.2_Missense_Mutation_p.S1072L|DOCK7_uc001dam.2_Missense_Mutation_p.S283L|DOCK7_uc010oov.1_5'Flank	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1103					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GTAAAGCTTTGAAGACACCTT	0.348													0	0	0	1	0	11	83										A	63003725	G	A	63003725	3	1	68	1	0	0	0	0	1	0	0	0	4692	1294	45	1	3206	1	DOCK7	1	63003725	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3755525	63003725	186246896	55	20575										
DEPDC1	55635	broad.mit.edu	37	chr1	68948008	68948008	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttcccattacacaactcctCttggtcttgaacagtcaaag	5	12	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:68948008C>T	uc001dem.3	-	8	1600	c.1483G>A	c.(1483-1485)GAG>AAG	p.E495K	DEPDC1_uc001dej.3_5'Flank|DEPDC1_uc001dek.3_Intron|DEPDC1_uc001del.3_Intron	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	495					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		CACAACTCCTCTTGGTCTTGA	0.368													0	0	0	1	0	19	74										T	68948008	C	T	68948008	3	4	68	1	0	0	0	0	1	0	0	0	4439	922	32	1	972	1	DEPDC1	1	68948008	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5944283	68948008	180302613	56	20576										
LRRIQ3	127255	broad.mit.edu	37	chr1	74492542	74492542	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttaaagtctaaatttgttttCacaattgctacttttgtttt	4	5	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:74492542C>T	uc001dfy.3	-	8	2022	c.1830G>A	c.(1828-1830)GTG>GTA	p.V610V	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	610	Potential.									ovary(2)	2						AATTTGTTTTCACAATTGCTA	0.284													0	0	0	1	0	6	41										T	74492542	C	T	74492542	2	4	68	1	0	0	0	0	0	0	0	1	9030	813	29	1		1	LRRIQ3	1	74492542	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5544534	74492542	174758079	57	20577										
C1orf173	127254	broad.mit.edu	37	chr1	75065508	75065508	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtctaaattatcttttttatCatccaaaggtgactgcggta	7	7	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:75065508C>T	uc001dgg.2	-	11	1816	c.1597G>A	c.(1597-1599)GAT>AAT	p.D533N	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.D327N	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	533	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTTTTTTATCATCCAAAGGT	0.398													0	0	0	1	0	58	115										T	75065508	C	T	75065508	3	4	68	1	0	0	0	0	1	0	0	0	2014	826	29	1	3011	1	C1orf173	1	75065508	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	572966	75065508	174185113	58	20578										
TYW3	127253	broad.mit.edu	37	chr1	75198988	75198988	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtttgagcaaagcggacctCagccggaagggcagtgttga	15	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:75198988C>T	uc001dgn.2	+	1	149	c.60C>T	c.(58-60)CTC>CTT	p.L20L	CRYZ_uc001dgk.2_5'UTR|CRYZ_uc001dgj.2_5'UTR|CRYZ_uc001dgl.2_5'UTR|CRYZ_uc001dgm.2_5'UTR|TYW3_uc010oqw.1_Silent_p.L20L|TYW3_uc010oqx.1_Silent_p.L20L|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	20					tRNA processing		methyltransferase activity			ovary(2)	2						AAGCGGACCTCAGCCGGAAGG	0.572													0	0	0	1	0	11	27										T	75198988	C	T	75198988	2	4	68	1	0	0	0	0	0	0	0	1	16817	813	29	1		1	TYW3	1	75198988	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	133480	75198988	174051633	59	20579										
DDAH1	23576	broad.mit.edu	37	chr1	85787136	85787136	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgggggggactctgcagctCaggagtctactttcttgtta	13	10	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:85787136C>G	uc001dlb.2	-	6	1018	c.857G>C	c.(856-858)TGA>TCA	p.*286S	DDAH1_uc001dlc.2_Nonstop_Mutation_p.*183S|uc001dla.1_Intron|DDAH1_uc010osb.1_Nonstop_Mutation_p.*186S|DDAH1_uc009wco.2_Nonstop_Mutation_p.*183S	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	286					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	CTCTGCAGCTCAGGAGTCTAC	0.532													0	0	0	1	0	12	43										G	85787136	C	G	85787136	4	3	68	1	0	0	0	0	0	0	0	0	4321	837	29	1	4	1	DDAH1	1	85787136	Nonstop_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10588148	85787136	163463485	60	20580										
LMO4	8543	broad.mit.edu	37	chr1	87797934	87797934	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgcagaaatgactacattaGgtaagactttgctgtctttc	8	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:87797934G>C	uc001dmi.2	+	2	1016	c.236G>C	c.(235-237)AGG>ACG	p.R79T	LMO4_uc001dmj.2_Missense_Mutation_p.R79T	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	79	LIM zinc-binding 1.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		GACTACATTAGGTAAGACTTT	0.537													0	0	0	1	0	18	19										C	87797934	G	C	87797934	3	2	68	1	0	0	0	0	1	0	0	0	8854	1014	35	4	238	4	LMO4	1	87797934	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2010798	87797934	161452687	61	20581										
ABCA4	24	broad.mit.edu	37	chr1	94496677	94496677	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaggtagccgggagcacgatCtgtgggagaatagacgtgga	17	6	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:94496677C>G	uc001dqh.2	-	28	4233	c.4129_splice	c.e28-1	p.I1377_splice		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4						phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGAGCACGATCTGTGGGAGAA	0.473													0	0	0	1	0	9	25										G	94496677	C	G	94496677	5	3	68	1	0	0	0	0	0	0	1	0	34	927	32	1	2785	1	ABCA4	1	94496677	Splice_Site	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6698743	94496677	154753944	62	20582										
HIAT1	64645	broad.mit.edu	37	chr1	100533744	100533744	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcctgggaacaagctgaccCttttgcggtaagtttatact	9	9	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:100533744C>G	uc001dst.2	+	6	698	c.698C>G	c.(697-699)CCT>CGT	p.P233R		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	233	Extracellular (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CAAGCTGACCCTTTTGCGGTA	0.413													0	0	0	1	0	6	34										G	100533744	C	G	100533744	3	3	68	1	0	0	0	0	1	0	0	0	7097	681	24	4	720	4	HIAT1	1	100533744	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6037067	100533744	148716877	63	20583										
COL11A1	1301	broad.mit.edu	37	chr1	103540254	103540254	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aattgctctctcacttctatCaagtggtttcgtggttttct	7	9	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:103540254C>T	uc001dul.2	-	4	889	c.571G>A	c.(571-573)GAT>AAT	p.D191N	COL11A1_uc001dum.2_Missense_Mutation_p.D191N|COL11A1_uc001dun.2_Missense_Mutation_p.D191N|COL11A1_uc009weh.2_Missense_Mutation_p.D191N	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	191	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCACTTCTATCAAGTGGTTTC	0.368													0	0	0	1	0	21	37										T	103540254	C	T	103540254	3	4	68	1	0	0	0	0	1	0	0	0	3667	826	29	1	5262	1	COL11A1	1	103540254	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3006510	103540254	145710367	64	20584										
FAM102B	284611	broad.mit.edu	37	chr1	109103119	109103119	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagctctcctcagtgcccttCgtcaatggggtcctcttctg	10	14	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:109103119C>T	uc010ouy.1	+	1	149	c.69C>T	c.(67-69)TTC>TTT	p.F23F		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	23										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		CAGTGCCCTTCGTCAATGGGG	0.607													0	0	0	1	0	8	33										T	109103119	C	T	109103119	2	4	68	1	0	0	0	0	0	0	0	1	5383	883	31	1		1	FAM102B	1	109103119	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5562865	109103119	140147502	65	20585										
TAF13	6884	broad.mit.edu	37	chr1	109617651	109617651	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttttaccctgtccaccttCtgcacctcctccaatttctt	2	17	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:109617651C>A	uc001dwm.1	-	2	119	c.64G>T	c.(64-66)GAA>TAA	p.E22*		NM_005645	NP_005636	Q15543	TAF13_HUMAN	TBP-associated factor 13	22					transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein C-terminus binding|sequence-specific DNA binding transcription factor activity				0		all_epithelial(167;0.000102)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0138)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.166)|all cancers(265;0.191)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGTCCACCTTCTGCACCTCCT	0.294													1	0	9.39024e-22	1	1.08151e-21	41	239										A	109617651	C	A	109617651	4	1	68	1	0	0	0	0	0	1	0	0	15514	922	32	3	322	3	TAF13	1	109617651	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	514532	109617651	139632970	66	20586										
MAGI3	260425	broad.mit.edu	37	chr1	114226264	114226264	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggtctccagagaaaaaaatCaaaagaatggttgagaaatc	9	5	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:114226264C>G	uc001edk.2	+	21	4255	c.4074C>G	c.(4072-4074)ATC>ATG	p.I1358M	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1383					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAAAAAAATCAAAAGAATGG	0.368													0	0	0	1	0	4	22										G	114226264	C	G	114226264	3	3	68	1	0	0	0	0	1	0	0	0	9192	816	29	1	4210	1	MAGI3	1	114226264	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4608613	114226264	135024357	67	20587										
DCLRE1B	64858	broad.mit.edu	37	chr1	114454730	114454730	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtctagcactcaaatatcttCtgactccagtgaactttttc	5	11	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:114454730C>T	uc001eeg.2	+	4	1687	c.1516C>T	c.(1516-1518)CTG>TTG	p.L506L	DCLRE1B_uc001eeh.2_Intron|DCLRE1B_uc001eei.2_Silent_p.L380L	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	506	TBM.			L->A: Abolishes interaction with TERF2.	cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAAATATCTTCTGACTCCAGT	0.498								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	1	0	26	129										T	114454730	C	T	114454730	2	4	68	1	0	0	0	0	0	0	0	1	4295	912	32	1		1	DCLRE1B	1	114454730	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	228466	114454730	134795891	68	20588										
CASQ2	845	broad.mit.edu	37	chr1	116260464	116260464	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggttgaaggtttcctacctgGatcactcttctctgcaaagg	10	10	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:116260464G>A	uc001efx.3	-	8	1099	c.835C>T	c.(835-837)CCA>TCA	p.P279S	CASQ2_uc010owu.1_Missense_Mutation_p.P208S	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	279					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTCCTACCTGGATCACTCTTC	0.453													0	0	0	1	0	18	110										A	116260464	G	A	116260464	3	1	68	1	0	0	0	0	1	0	0	0	2681	1174	41	1	380	1	CASQ2	1	116260464	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1805734	116260464	132990157	69	20589										
CD101	9398	broad.mit.edu	37	chr1	117564240	117564240	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagtcaagtccaagagctctCcatcaactccaacactgata	6	13	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:117564240C>A	uc010oxb.1	+	7	2121	c.2063C>A	c.(2062-2064)TCC>TAC	p.S688Y	CD101_uc009whd.2_Missense_Mutation_p.S688Y|CD101_uc010oxc.1_Missense_Mutation_p.S688Y|CD101_uc010oxd.1_Missense_Mutation_p.S626Y	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	688	Ig-like C2-type 6.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CAAGAGCTCTCCATCAACTCC	0.343													1	0	0.184627	1	0.184921	5	32										A	117564240	C	A	117564240	3	1	68	1	0	0	0	0	1	0	0	0	2962	855	30	3	2089	3	CD101	1	117564240	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1303776	117564240	131686381	70	20590										
HSD3B1	3283	broad.mit.edu	37	chr1	120054248	120054248	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctgtatcattgatgtcttcGgtgtcactcacagagagtct	9	10	5	2	rs6684974	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:120054248G>A	uc001ehv.1	+	3	413	c.268G>A	c.(268-270)GGT>AGT	p.G90S	HSD3B1_uc001ehw.2_Missense_Mutation_p.G92S	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	90					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	TGATGTCTTCGGTGTCACTCA	0.502													0	0	0	1	0	20	95										A	120054248	G	A	120054248	3	1	68	1	0	0	0	0	1	0	0	0	7390	1116	39	2	274	2	HSD3B1	1	120054248	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2490008	120054248	129196373	71	20591										
PDE4DIP	9659	broad.mit.edu	37	chr1	144882612	144882612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagatgcacaaggagctctGgagtaagtttactattccct	9	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:144882612G>A	uc001elw.3	-	24	3698	c.3407C>T	c.(3406-3408)CCA>CTA	p.P1136L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.P143L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1136					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AAGGAGCTCTGGAGTAAGTTT	0.463			T	PDGFRB	MPD								0	0	0	1	0	53	312										A	144882612	G	A	144882612	3	1	68	1	0	0	0	0	1	0	0	0	11643	1348	47	2	3717	2	PDE4DIP	1	144882612	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	24828364	144882612	104368009	72	20592										
BOLA1	51027	broad.mit.edu	37	chr1	149871751	149871751	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggaggaggccctgagccccGaggtgctagagcttcgcaac	15	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:149871751G>T	uc001etf.2	+	2	260	c.139G>T	c.(139-141)GAG>TAG	p.E47*		NM_016074	NP_057158	Q9Y3E2	BOLA1_HUMAN	bolA-like 1	47						extracellular region	protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCTGAGCCCCGAGGTGCTAGA	0.677													1	0	1.12685e-05	1	1.18122e-05	8	59										T	149871751	G	T	149871751	4	4	68	1	0	0	0	0	0	1	0	0	1485	1059	37	3	141	3	BOLA1	1	149871751	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4989139	149871751	99378870	73	20593										
C1orf51	148523	broad.mit.edu	37	chr1	150259019	150259019	+	Missense_Mutation	SNP	C	C	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccaatttgcaacccccctCtcagctccccaggtactatc							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:150259019C>T	uc001euh.2	+	6	947	c.811C>T	c.(811-813)CTC>TTC	p.L271F	C1orf51_uc001eui.2_Missense_Mutation_p.L183F|C1orf51_uc001euj.2_Missense_Mutation_p.L271F	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	271											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAACCCCCCTCTCAGCTCCCC	0.522													0	0	0	1	0	21	180										T	150259019	C	T	150259019	3	4	68	1	0	0	0	0	1	0	0	0	2043	913	32	1	829	1	C1orf51	1	150259019	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	387268	150259019	98991602	74	20594	105	2								
C1orf51	148523	broad.mit.edu	37	chr1	150259021	150259021	+	Silent	SNP	C	C	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaatttgcaacccccctctCagctccccaggtactatctc							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:150259021C>T	uc001euh.2	+	6	949	c.813C>T	c.(811-813)CTC>CTT	p.L271L	C1orf51_uc001eui.2_Silent_p.L183L|C1orf51_uc001euj.2_Silent_p.L271L	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	271											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACCCCCCTCTCAGCTCCCCAG	0.527													0	0	0	1	0	16	185										T	150259021	C	T	150259021	2	4	68	1	0	0	0	0	0	0	0	1	2043	813	29	1		1	C1orf51	1	150259021	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2	150259021	98991600	75	20595	105	2								
TARS2	80222	broad.mit.edu	37	chr1	150463082	150463082	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttttgtgaacccaggtgttCtggcactccagcacccatgt	9	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:150463082C>G	uc001euq.2	+	4	400	c.393C>G	c.(391-393)TTC>TTG	p.F131L	TARS2_uc010pcd.1_Intron|TARS2_uc001eur.2_Missense_Mutation_p.F131L|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Missense_Mutation_p.F131L	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	131					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCCAGGTGTTCTGGCACTCCA	0.488													0	0	0	1	0	22	125										G	150463082	C	G	150463082	3	3	68	1	0	0	0	0	1	0	0	0	15557	912	32	1	407	1	TARS2	1	150463082	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	204061	150463082	98787539	76	20596										
HORMAD1	84072	broad.mit.edu	37	chr1	150676602	150676602	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcaagtttatacctgagaatGagaaatagaaagatctggac	9	5	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:150676602G>C	uc001evk.1	-	12	1046	c.940C>G	c.(940-942)CAT>GAT	p.H314D	HORMAD1_uc001evl.1_Missense_Mutation_p.H307D|HORMAD1_uc001evm.1_Missense_Mutation_p.H234D	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	314					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			ACCTGAGAATGAGAAATAGAA	0.308													0	0	0	1	0	13	10										C	150676602	G	C	150676602	3	2	68	1	0	0	0	0	1	0	0	0	7286	1290	45	1	260	1	HORMAD1	1	150676602	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	213520	150676602	98574019	77	20597										
SETDB1	9869	broad.mit.edu	37	chr1	150936790	150936790	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgggcagtgtggaaggcaagGagctactctgttgctgtggg	18	6	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:150936790G>C	uc001evu.2	+	22	4016	c.3826G>C	c.(3826-3828)GAG>CAG	p.E1276Q	SETDB1_uc001evv.2_Missense_Mutation_p.E1275Q	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1276	Post-SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAAGGCAAGGAGCTACTCTG	0.507													0	0	0	1	0	10	60										C	150936790	G	C	150936790	3	2	68	1	0	0	0	0	1	0	0	0	14138	1175	41	1	3908	1	SETDB1	1	150936790	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	260188	150936790	98313831	78	20598										
PIP5K1A	8394	broad.mit.edu	37	chr1	151214948	151214948	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgtcctgatgttttacctcaGactccacctttggaggaaat	8	11	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:151214948G>C	uc001exj.2	+	14	1997	c.1545G>C	c.(1543-1545)CAG>CAC	p.Q515H	PIP5K1A_uc001exi.2_Missense_Mutation_p.Q502H|PIP5K1A_uc010pcu.1_Missense_Mutation_p.Q475H|PIP5K1A_uc001exk.2_Missense_Mutation_p.Q453H|PIP5K1A_uc010pcv.1_Intron	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	515					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTTTACCTCAGACTCCACCTT	0.458													0	0	0	1	0	37	132										C	151214948	G	C	151214948	3	2	68	1	0	0	0	0	1	0	0	0	11939	933	33	1	1599	1	PIP5K1A	1	151214948	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	278158	151214948	98035673	79	20599										
ZNF687	57592	broad.mit.edu	37	chr1	151259814	151259814	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acaaggactgtaactcaggtCccctcagatcctgatccacc	7	15	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:151259814C>T	uc001exq.2	+	2	1145	c.1047C>T	c.(1045-1047)GTC>GTT	p.V349V	ZNF687_uc001exp.1_Silent_p.V358V|ZNF687_uc009wmo.2_Silent_p.V349V|ZNF687_uc009wmp.2_Silent_p.V349V	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TAACTCAGGTCCCCTCAGATC	0.562													0	0	0	1	0	39	60										T	151259814	C	T	151259814	2	4	68	1	0	0	0	0	0	0	0	1	18089	842	30	1		1	ZNF687	1	151259814	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	44866	151259814	97990807	80	20600										
LINGO4	339398	broad.mit.edu	37	chr1	151773919	151773919	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctcctctgcaatgacccatCgaggccccgactttcggatc	8	17	1	1	rs143154971		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:151773919C>T	uc001ezf.1	-	2	1452	c.1262G>A	c.(1261-1263)CGA>CAA	p.R421Q		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	421	Extracellular (Potential).|Ig-like C2-type.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AATGACCCATCGAGGCCCCGA	0.607													0	0	0	1	0	13	126										T	151773919	C	T	151773919	3	4	68	1	0	0	0	0	1	0	0	0	8817	884	31	1	523	1	LINGO4	1	151773919	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	514105	151773919	97476702	81	20601										
TCHH	7062	broad.mit.edu	37	chr1	152083292	152083292	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcccgctgctggcgctcctCggccctcagctgcctctccc	9	21	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:152083292C>A	uc001ezp.2	-	2	2401	c.2401G>T	c.(2401-2403)GAG>TAG	p.E801*	TCHH_uc009wne.1_Nonsense_Mutation_p.E801*	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	801					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGCGCTCCTCGGCCCTCAGC	0.682													1	0	2.23348e-06	1	2.36288e-06	16	95										A	152083292	C	A	152083292	4	1	68	1	0	0	0	0	0	1	0	0	15697	893	31	3	3434	3	TCHH	1	152083292	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	309373	152083292	97167329	82	20602										
FLG	2312	broad.mit.edu	37	chr1	152279889	152279889	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgggatgtggtgtggctgtgAtgagaccctgagtgtccaga	17	6	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:152279889A>C	uc001ezu.1	-	3	7509	c.7473T>G	c.(7471-7473)CAT>CAG	p.H2491Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2491	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGGCTGTGATGAGACCCTG	0.542									Ichthyosis				0	0	0	1	0	186	609										C	152279889	A	C	152279889	3	2	68	1	0	0	0	0	1	0	0	0	5922	330	12	5	4716	5	FLG	1	152279889	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	196597	152279889	96970732	83	20603										
NUP210L	91181	broad.mit.edu	37	chr1	154076593	154076593	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttggtctctttatttatgtGatacattgcaatgggtattt	8	4	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:154076593G>A	uc001fdw.2	-	13	1786	c.1714C>T	c.(1714-1716)CAC>TAC	p.H572Y	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.H572Y	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	572						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTATTTATGTGATACATTGCA	0.388													0	0	0	1	0	20	126										A	154076593	G	A	154076593	3	1	68	1	0	0	0	0	1	0	0	0	10761	1290	45	1	4064	1	NUP210L	1	154076593	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1796704	154076593	95174028	84	20604										
ADAR	103	broad.mit.edu	37	chr1	154573729	154573729	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtgctgcgcggatactattCaagtcatctgggatgtcatc	12	9	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:154573729C>T	uc001ffh.2	-	2	1589	c.1389G>A	c.(1387-1389)TTG>TTA	p.L463L	ADAR_uc001ffj.2_Silent_p.L463L|ADAR_uc001ffi.2_Silent_p.L463L|ADAR_uc001ffk.2_Silent_p.L168L|ADAR_uc001ffl.1_Silent_p.L168L	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	463					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GGATACTATTCAAGTCATCTG	0.498													0	0	0	1	0	8	68										T	154573729	C	T	154573729	2	4	68	1	0	0	0	0	0	0	0	1	281	825	29	1		1	ADAR	1	154573729	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	497136	154573729	94676892	85	20605										
TRIM46	80128	broad.mit.edu	37	chr1	155149435	155149435	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtgcccagaccacaaggaaGaggtgacccactactgcaag	11	12	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:155149435G>A	uc001fhs.1	+	4	780	c.697G>A	c.(697-699)GAG>AAG	p.E233K	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Missense_Mutation_p.E220K|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.E233K|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.E107K|TRIM46_uc001fhu.1_Missense_Mutation_p.E210K|TRIM46_uc009wpg.1_Missense_Mutation_p.E220K|TRIM46_uc001fhv.3_Missense_Mutation_p.E220K|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	233	B box-type.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCACAAGGAAGAGGTGACCCA	0.557											OREG0013855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	50	93										A	155149435	G	A	155149435	3	1	68	1	0	0	0	0	1	0	0	0	16518	943	33	1	711	1	TRIM46	1	155149435	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	575706	155149435	94101186	86	20606										
RUSC1	23623	broad.mit.edu	37	chr1	155294700	155294700	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtggatggcagaagcccaGagtgggactggtcagctgca	16	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:155294700G>A	uc001fkj.2	+	3	1651	c.1422G>A	c.(1420-1422)CAG>CAA	p.Q474Q	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Silent_p.Q474Q|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_Silent_p.Q5Q|RUSC1_uc001fkl.2_Silent_p.Q64Q|RUSC1_uc001fkp.2_Silent_p.Q5Q|RUSC1_uc001fkq.2_Silent_p.Q5Q|RUSC1_uc010pgb.1_Silent_p.Q5Q|RUSC1_uc009wqp.1_5'UTR|RUSC1_uc001fkn.2_Intron|RUSC1_uc001fko.2_Intron|RUSC1_uc001fkr.2_Silent_p.Q5Q|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	474						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CAGAAGCCCAGAGTGGGACTG	0.642											OREG0013860	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	34	122										A	155294700	G	A	155294700	2	1	68	1	0	0	0	0	0	0	0	1	13750	933	33	1		1	RUSC1	1	155294700	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	145265	155294700	93955921	87	20607										
FCRL2	79368	broad.mit.edu	37	chr1	157738293	157738293	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgccggcatcactctctttcAcagctgggatctccagctct	8	15	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:157738293A>G	uc001fre.2	-	5	853	c.794T>C	c.(793-795)GTG>GCG	p.V265A	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.V265A|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	265	Ig-like C2-type 3.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTCTCTTTCACAGCTGGGAT	0.507													0	0	0	1	0	56	247										G	157738293	A	G	157738293	3	3	68	1	0	0	0	0	1	0	0	0	5795	159	6	5	764	5	FCRL2	1	157738293	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2443593	157738293	91512328	88	20608										
CD1B	910	broad.mit.edu	37	chr1	158299235	158299235	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caggccagccgcctccccatCtgccacatccagggttgctc	9	19	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:158299235C>A	uc001frx.2	-	4	919	c.811G>T	c.(811-813)GAT>TAT	p.D271Y	CD1B_uc001frw.2_Intron	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	271	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					GCCTCCCCATCTGCCACATCC	0.592													1	0	3.27435e-08	1	3.53832e-08	12	235										A	158299235	C	A	158299235	3	1	68	1	0	0	0	0	1	0	0	0	2975	913	32	3	202	3	CD1B	1	158299235	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	560942	158299235	90951386	89	20609										
SPTA1	6708	broad.mit.edu	37	chr1	158607885	158607885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacaaggcataggcctctttCaatttttcgtggtgtgcagc	10	9	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:158607885C>G	uc001fst.1	-	36	5326	c.5127G>C	c.(5125-5127)TTG>TTC	p.L1709F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1709	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGGCCTCTTTCAATTTTTCGT	0.423													0	0	0	1	0	16	186										G	158607885	C	G	158607885	3	3	68	1	0	0	0	0	1	0	0	0	15115	825	29	1	2200	1	SPTA1	1	158607885	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	308650	158607885	90642736	90	20610										
OR6N2	81442	broad.mit.edu	37	chr1	158746673	158746673	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgaagatgatgctcccaaaGaagatgaggaccacagcaag	11	8	0	6			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:158746673G>A	uc010pir.1	-	1	753	c.753C>T	c.(751-753)TTC>TTT	p.F251F		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TGCTCCCAAAGAAGATGAGGA	0.458													0	0	0	1	0	9	115										A	158746673	G	A	158746673	2	1	68	1	0	0	0	0	0	0	0	1	11207	933	33	1		1	OR6N2	1	158746673	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	138788	158746673	90503948	91	20611										
KCNJ9	3765	broad.mit.edu	37	chr1	160054012	160054012	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgcctcagcctgttgttcttCgtcctggcctacgcgctcac	9	17	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:160054012C>T	uc001fuy.1	+	2	434	c.192C>T	c.(190-192)TTC>TTT	p.F64F		NM_004983	NP_004974	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel subfamily	64	Helical; Name=M1; (By similarity).				synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			ovary(1)|skin(1)	2	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTTGTTCTTCGTCCTGGCCT	0.657													0	0	0	1	0	7	46										T	160054012	C	T	160054012	2	4	68	1	0	0	0	0	0	0	0	1	8057	883	31	1		1	KCNJ9	1	160054012	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1307339	160054012	89196609	92	20612										
PPOX	5498	broad.mit.edu	37	chr1	161138284	161138284	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcaggcaacagccgtgagctCagcatcaggtcctgctttcc	11	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:161138284C>T	uc001fyj.2	+	6	824	c.534C>T	c.(532-534)CTC>CTT	p.L178L	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Silent_p.L178L|PPOX_uc001fyl.2_Silent_p.L144L|PPOX_uc001fym.2_Intron|PPOX_uc001fyk.2_Silent_p.L16L|PPOX_uc001fyh.2_Silent_p.L16L|PPOX_uc010pkg.1_Silent_p.L16L|PPOX_uc009wuc.1_Silent_p.L16L|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Silent_p.L16L	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	178					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GCCGTGAGCTCAGCATCAGGT	0.542									Porphyria_Variegata				0	0	0	1	0	17	232										T	161138284	C	T	161138284	2	4	68	1	0	0	0	0	0	0	0	1	12348	813	29	1		1	PPOX	1	161138284	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1084272	161138284	88112337	93	20613										
PPOX	5498	broad.mit.edu	37	chr1	161139803	161139803	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcagtaccaaggagcccatCtgcctgtccaggtatgataa	10	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:161139803C>G	uc001fyj.2	+	9	1266	c.976C>G	c.(976-978)CTG>GTG	p.L326V	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Missense_Mutation_p.L326V|PPOX_uc001fyl.2_Missense_Mutation_p.L292V|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Missense_Mutation_p.L164V|PPOX_uc001fyh.2_Missense_Mutation_p.L164V|PPOX_uc010pkg.1_Missense_Mutation_p.L164V|PPOX_uc009wuc.1_Missense_Mutation_p.L164V|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Missense_Mutation_p.L164V	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	326					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGGAGCCCATCTGCCTGTCCA	0.383									Porphyria_Variegata				0	0	0	1	0	10	58										G	161139803	C	G	161139803	3	3	68	1	0	0	0	0	1	0	0	0	12348	912	32	1	1006	1	PPOX	1	161139803	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1519	161139803	88110818	94	20614										
PPOX	5498	broad.mit.edu	37	chr1	161140823	161140823	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctttcatcctttccttccaGagtcagctaggcaattcctg	6	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:161140823G>C	uc001fyj.2	+	13	1582	c.1292_splice	c.e13-1	p.E431_splice	PPOX_uc001fyn.2_Splice_Site_p.E139_splice|PPOX_uc001fyg.2_Splice_Site_p.E431_splice|PPOX_uc001fyl.2_Splice_Site_p.E397_splice|PPOX_uc001fym.2_Splice_Site|PPOX_uc001fyk.2_Splice_Site_p.E269_splice|PPOX_uc001fyh.2_Splice_Site_p.E269_splice|PPOX_uc010pkg.1_Splice_Site_p.E269_splice|PPOX_uc009wuc.1_Splice_Site_p.E232_splice|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Intron	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase						heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TTTCCTTCCAGAGTCAGCTAG	0.517									Porphyria_Variegata				0	0	0	1	0	35	350										C	161140823	G	C	161140823	5	2	68	1	0	0	0	0	0	0	1	0	12348	956	33	1	1337	1	PPOX	1	161140823	Splice_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1020	161140823	88109798	95	20615										
SDHC	6391	broad.mit.edu	37	chr1	161298268	161298268	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttcaaaccgtcctctgtctCcccacattactatctacagg	5	15	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:161298268C>A	uc001gag.2	+	3	190	c.160C>A	c.(160-162)CCC>ACC	p.P54T	SDHC_uc001gai.2_Missense_Mutation_p.P54T|SDHC_uc001gaj.2_Intron|SDHC_uc001gak.2_Intron|SDHC_uc001gah.2_Intron	NM_003001	NP_002992	Q99643	C560_HUMAN	succinate dehydrogenase complex, subunit C	54	Mitochondrial matrix (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II|plasma membrane succinate dehydrogenase complex	electron carrier activity|heme binding|succinate dehydrogenase activity				0	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Succinic acid(DB00139)	TCCTCTGTCTCCCCACATTAC	0.443			Mis|N|F			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome				1	0	3.35115e-56	1	3.90244e-56	122	75										A	161298268	C	A	161298268	3	1	68	1	0	0	0	0	1	0	0	0	13966	855	30	3	170	3	SDHC	1	161298268	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	157445	161298268	87952353	96	20616										
ADCY10	55811	broad.mit.edu	37	chr1	167815465	167815465	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atctcaccagcatttggtggGaaagtctcatgctatccagc	9	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:167815465G>A	uc001ger.2	-	20	2772	c.2474C>T	c.(2473-2475)TCC>TTC	p.S825F	ADCY10_uc009wvk.2_Missense_Mutation_p.S733F|ADCY10_uc010plj.1_Missense_Mutation_p.S672F|ADCY10_uc009wvl.2_Missense_Mutation_p.S824F	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	825					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CATTTGGTGGGAAAGTCTCAT	0.418													0	0	0	1	0	32	278										A	167815465	G	A	167815465	3	1	68	1	0	0	0	0	1	0	0	0	293	1174	41	1	2414	1	ADCY10	1	167815465	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6517197	167815465	81435156	97	20617										
PRDX6	9588	broad.mit.edu	37	chr1	173454569	173454569	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccatcatcgatgataggaatCgggagcttgccatcctgttg	11	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:173454569C>T	uc001giy.1	+	3	373	c.322C>T	c.(322-324)CGG>TGG	p.R108W		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	108	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						TGATAGGAATCGGGAGCTTGC	0.448													0	0	0	1	0	25	66										T	173454569	C	T	173454569	3	4	68	1	0	0	0	0	1	0	0	0	12469	875	31	1	332	1	PRDX6	1	173454569	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5639104	173454569	75796052	98	20618										
SLC9A11	284525	broad.mit.edu	37	chr1	173486775	173486775	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtagtacagaactctgtaaaCatgtctctggaccctctatc	7	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:173486775C>A	uc001giz.2	-	23	3231	c.2808G>T	c.(2806-2808)ATG>ATT	p.M936I	SLC9A11_uc009wwe.2_Missense_Mutation_p.M494I	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	936	cNMP.				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						ACTCTGTAAACATGTCTCTGG	0.403													1	0	3.27435e-08	1	3.53832e-08	15	123										A	173486775	C	A	173486775	3	1	68	1	0	0	0	0	1	0	0	0	14711	478	17	4	590	4	SLC9A11	1	173486775	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	32206	173486775	75763846	99	20619										
CEP350	9857	broad.mit.edu	37	chr1	179989239	179989239	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgcataaggattttgaatCtattttaccaaccaggaaga	7	6	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:179989239C>G	uc001gnt.2	+	12	2713	c.2330C>G	c.(2329-2331)TCT>TGT	p.S777C	CEP350_uc009wxl.2_Missense_Mutation_p.S776C|CEP350_uc001gnu.2_Missense_Mutation_p.S611C	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	777						centrosome|nucleus|spindle				ovary(4)	4						GATTTTGAATCTATTTTACCA	0.408													0	0	0	1	0	12	109										G	179989239	C	G	179989239	3	3	68	1	0	0	0	0	1	0	0	0	3254	913	32	1	2372	1	CEP350	1	179989239	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6502464	179989239	69261382	100	20620										
CEP350	9857	broad.mit.edu	37	chr1	179989832	179989832	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagacaaagccaaaatatctCttggttccagcatagattca	6	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:179989832C>G	uc001gnt.2	+	12	3306	c.2923C>G	c.(2923-2925)CTT>GTT	p.L975V	CEP350_uc009wxl.2_Missense_Mutation_p.L974V|CEP350_uc001gnu.2_Missense_Mutation_p.L809V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	975						centrosome|nucleus|spindle				ovary(4)	4						CAAAATATCTCTTGGTTCCAG	0.473													0	0	0	1	0	23	145										G	179989832	C	G	179989832	3	3	68	1	0	0	0	0	1	0	0	0	3254	913	32	1	2965	1	CEP350	1	179989832	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	593	179989832	69260789	101	20621										
RGS16	6004	broad.mit.edu	37	chr1	182572430	182572430	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagtatcgcagcccagctctGatttgtgaagaaagatcccc	9	12	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:182572430G>A	uc001gpl.3	-	2	243	c.89C>T	c.(88-90)TCA>TTA	p.S30L	RGS16_uc010pnv.1_Missense_Mutation_p.S30L	NM_002928	NP_002919	O15492	RGS16_HUMAN	regulator of G-protein signalling 16	30					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(1)	1						GCCCAGCTCTGATTTGTGAAG	0.488													0	0	0	1	0	49	63										A	182572430	G	A	182572430	3	1	68	1	0	0	0	0	1	0	0	0	13298	1294	45	1	535	1	RGS16	1	182572430	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2582598	182572430	66678191	102	20622										
LAMC1	3915	broad.mit.edu	37	chr1	183086694	183086694	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcttgggcaagcaggtgttGagttatggtcagaacctctc	12	8	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:183086694G>C	uc001gpy.3	+	10	1970	c.1713G>C	c.(1711-1713)TTG>TTC	p.L571F		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	571	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCAGGTGTTGAGTTATGGTC	0.502													0	0	0	1	0	12	68										C	183086694	G	C	183086694	3	2	68	1	0	0	0	0	1	0	0	0	8614	1281	45	1	1751	1	LAMC1	1	183086694	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	514264	183086694	66163927	103	20623										
HMCN1	83872	broad.mit.edu	37	chr1	186151338	186151338	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atacagatgcctgccagcatGagtgtaagaatacctttgga	10	8	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:186151338G>A	uc001grq.1	+	105	16562	c.16333G>A	c.(16333-16335)GAG>AAG	p.E5445K	HMCN1_uc001grs.1_Missense_Mutation_p.E897K	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5445	EGF-like 7; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CTGCCAGCATGAGTGTAAGAA	0.423													0	0	0	1	0	41	81										A	186151338	G	A	186151338	3	1	68	1	0	0	0	0	1	0	0	0	7220	1291	45	1	16751	1	HMCN1	1	186151338	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3064644	186151338	63099283	104	20624										
CFHR1	3078	broad.mit.edu	37	chr1	196797300	196797300	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agagtacgttatgaatgtagGagcccttatgaaatgtttgg	12	4	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:196797300G>A	uc001gtn.2	+	4	645	c.531G>A	c.(529-531)AGG>AGA	p.R177R	CFHR1_uc001gtm.2_Silent_p.R81R	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	177	Sushi 3.				complement activation	extracellular space					0						ATGAATGTAGGAGCCCTTATG	0.393													0	0	0	1	0	19	31										A	196797300	G	A	196797300	2	1	68	1	0	0	0	0	0	0	0	1	3284	1165	41	1		1	CFHR1	1	196797300	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10645962	196797300	52453321	105	20625										
CFHR4	10877	broad.mit.edu	37	chr1	196883726	196883726	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acgaatgctacgatggatatGaaatcagttatggaaacacc	9	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:196883726G>T	uc001gto.2	+	4	610	c.541G>T	c.(541-543)GAA>TAA	p.E181*	CFHR4_uc009wyy.2_Nonsense_Mutation_p.E427*|CFHR4_uc001gtp.2_Nonsense_Mutation_p.E428*	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	181	Sushi 3.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						CGATGGATATGAAATCAGTTA	0.388													1	0	1.02788e-11	1	1.15021e-11	16	60										T	196883726	G	T	196883726	4	4	68	1	0	0	0	0	0	1	0	0	3287	1291	45	3	555	3	CFHR4	1	196883726	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	86426	196883726	52366895	106	20626										
KIF14	9928	broad.mit.edu	37	chr1	200587334	200587334	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtacagaagaggcaacaaaaGagtttttagcattatttaca	8	5	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:200587334G>C	uc010ppk.1	-	2	957	c.518C>G	c.(517-519)TCT>TGT	p.S173C	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	173	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						GGCAACAAAAGAGTTTTTAGC	0.358													0	0	0	1	0	37	75										C	200587334	G	C	200587334	3	2	68	1	0	0	0	0	1	0	0	0	8276	942	33	1	4544	1	KIF14	1	200587334	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3703608	200587334	48663287	107	20627										
KIF14	9928	broad.mit.edu	37	chr1	200587382	200587382	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catttgttctactttccttaGaaacaccattattttctgtt	3	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:200587382G>C	uc010ppk.1	-	2	909	c.470C>G	c.(469-471)TCT>TGT	p.S157C	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	157	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						ACTTTCCTTAGAAACACCATT	0.353													0	0	0	1	0	24	61										C	200587382	G	C	200587382	3	2	68	1	0	0	0	0	1	0	0	0	8276	942	33	1	4592	1	KIF14	1	200587382	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	48	200587382	48663239	108	20628										
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200819297	200819297	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgtacctgttgaaaaatatGatggagaaagtgataaagaa	10	2	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:200819297G>A	uc001gvl.2	+	12	3703	c.3433G>A	c.(3433-3435)GAT>AAT	p.D1145N	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.D1134N|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.D1118N	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1145						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TGAAAAATATGATGGAGAAAG	0.373													0	0	0	1	0	26	110										A	200819297	G	A	200819297	3	1	68	1	0	0	0	0	1	0	0	0	2612	1290	45	1	3442	1	CAMSAP1L1	1	200819297	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	231915	200819297	48431324	109	20629										
KIF21B	23046	broad.mit.edu	37	chr1	200954093	200954093	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgggggtgtgaatcccacatCtgtggacctggtgagtcggg	17	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:200954093C>T	uc001gvs.1	-	27	4014	c.3697G>A	c.(3697-3699)GAT>AAT	p.D1233N	KIF21B_uc001gvr.1_Missense_Mutation_p.D1233N|KIF21B_uc009wzl.1_Missense_Mutation_p.D1233N|KIF21B_uc010ppn.1_Missense_Mutation_p.D1233N	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1233					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						AATCCCACATCTGTGGACCTG	0.612													0	0	0	1	0	8	40										T	200954093	C	T	200954093	3	4	68	1	0	0	0	0	1	0	0	0	8289	913	32	1	1209	1	KIF21B	1	200954093	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	134796	200954093	48296528	110	20630										
CACNA1S	779	broad.mit.edu	37	chr1	201030512	201030512	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcaatgaggatgatgtagatGatgaagaagatggccatctc	13	5	1	7			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:201030512G>A	uc001gvv.2	-	25	3365	c.3138C>T	c.(3136-3138)ATC>ATT	p.I1046I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1046	III.|Helical; Name=S6 of repeat III; (Potential).|Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGATGTAGATGATGAAGAAGA	0.517													0	0	0	1	0	13	54										A	201030512	G	A	201030512	2	1	68	1	0	0	0	0	0	0	0	1	2547	1280	45	1		1	CACNA1S	1	201030512	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	76419	201030512	48220109	111	20631										
CACNA1S	779	broad.mit.edu	37	chr1	201035414	201035414	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggagcaccctcagcaccctCaggatcttcaccacggagat	9	16	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:201035414C>T	uc001gvv.2	-	21	2915	c.2688G>A	c.(2686-2688)CTG>CTA	p.L896L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	896	III.|Helical; Name=S4 of repeat III; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCAGCACCCTCAGGATCTTCA	0.662													0	0	0	1	0	12	65										T	201035414	C	T	201035414	2	4	68	1	0	0	0	0	0	0	0	1	2547	813	29	1		1	CACNA1S	1	201035414	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4902	201035414	48215207	112	20632										
LGR6	59352	broad.mit.edu	37	chr1	202272426	202272426	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatctctgaatggtgccatgGacatccaggagtttccagat	11	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:202272426G>T	uc001gxu.2	+	10	949	c.949G>T	c.(949-951)GAC>TAC	p.D317Y	LGR6_uc001gxv.2_Missense_Mutation_p.D265Y|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.D178Y|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	317	LRR 10.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGGTGCCATGGACATCCAGGA	0.502													1	0	5.35267e-07	1	5.71072e-07	17	62										T	202272426	G	T	202272426	3	4	68	1	0	0	0	0	1	0	0	0	8758	1174	41	3	1134	3	LGR6	1	202272426	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1237012	202272426	46978195	113	20633										
LGR6	59352	broad.mit.edu	37	chr1	202273726	202273726	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atccggctgctcccatcgggGatgtgccaacagctgcccag	12	15	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:202273726G>C	uc001gxu.2	+	11	1038	c.1038G>C	c.(1036-1038)GGG>GGC	p.G346G	LGR6_uc001gxv.2_Silent_p.G294G|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.G207G|LGR6_uc009xac.1_RNA	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	346	LRR 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TCCCATCGGGGATGTGCCAAC	0.632													0	0	0	1	0	6	40										C	202273726	G	C	202273726	2	2	68	1	0	0	0	0	0	0	0	1	8758	1161	41	1		1	LGR6	1	202273726	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1300	202273726	46976895	114	20634										
LGR6	59352	broad.mit.edu	37	chr1	202278242	202278242	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttgggggcttgatgcatctGaagctcaaagggaaccttgc	13	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:202278242G>A	uc001gxu.2	+	15	1344	c.1344G>A	c.(1342-1344)CTG>CTA	p.L448L	LGR6_uc001gxv.2_Silent_p.L396L|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Silent_p.L309L	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	448	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGATGCATCTGAAGCTCAAAG	0.567													0	0	0	1	0	5	51										A	202278242	G	A	202278242	2	1	68	1	0	0	0	0	0	0	0	1	8758	1277	45	1		1	LGR6	1	202278242	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4516	202278242	46972379	115	20635										
LGR6	59352	broad.mit.edu	37	chr1	202283965	202283965	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgagctccagctggagatgGaggactcaaagccacacccc	11	13	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:202283965G>T	uc001gxu.2	+	17	1603	c.1603G>T	c.(1603-1605)GAG>TAG	p.E535*	LGR6_uc001gxv.2_Nonsense_Mutation_p.E483*|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Nonsense_Mutation_p.E396*	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	535	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						GCTGGAGATGGAGGACTCAAA	0.572													1	0	0.00198382	1	0.0020207	7	30										T	202283965	G	T	202283965	4	4	68	1	0	0	0	0	0	1	0	0	8758	1175	41	3	1816	3	LGR6	1	202283965	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5723	202283965	46966656	116	20636										
CDK18	5129	broad.mit.edu	37	chr1	205492313	205492313	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcatgatcatgaacaagatGaagaactttaagcgccgttt	8	8	2	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:205492313G>T	uc001hcr.2	+	2	237	c.18G>T	c.(16-18)ATG>ATT	p.M6I	CDK18_uc009xbk.1_Intron|CDK18_uc009xbl.1_Intron|CDK18_uc010pri.1_5'UTR|CDK18_uc001hcp.2_Missense_Mutation_p.M6I|CDK18_uc001hcq.2_Missense_Mutation_p.M6I|CDK18_uc010prj.1_5'UTR|CDK18_uc001hcs.2_5'UTR|CDK18_uc009xbm.1_5'Flank	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	4							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						TGAACAAGATGAAGAACTTTA	0.517													1	0	0.0477658	1	0.0481479	8	53										T	205492313	G	T	205492313	3	4	68	1	0	0	0	0	1	0	0	0	3134	1290	45	3	20	3	CDK18	1	205492313	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3208348	205492313	43758308	117	20637										
CD46	4179	broad.mit.edu	37	chr1	207940986	207940986	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtacaaaacctccagctttGagtcattcaggtttagtagc	8	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:207940986G>C	uc001hgc.2	+	7	1047	c.891G>C	c.(889-891)TTG>TTC	p.L297F	CD46_uc001hgd.2_Intron|CD46_uc001hge.2_Intron|CD46_uc001hgf.2_Intron|CD46_uc001hgg.2_Intron|CD46_uc001hgh.2_Intron|CD46_uc001hgi.2_Intron|CD46_uc001hgj.2_Missense_Mutation_p.L297F|CD46_uc001hgk.2_Missense_Mutation_p.L297F|CD46_uc001hgl.2_Intron|CD46_uc001hgm.2_Intron|CD46_uc001hgn.2_Intron|CD46_uc001hgo.2_Missense_Mutation_p.L297F|CD46_uc001hgp.2_Intron	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	297	Extracellular (Potential).				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4						CTCCAGCTTTGAGTCATTCAG	0.368													0	0	0	1	0	21	102										C	207940986	G	C	207940986	3	2	68	1	0	0	0	0	1	0	0	0	3018	1281	45	1	917	1	CD46	1	207940986	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2448673	207940986	41309635	118	20638										
IRF6	3664	broad.mit.edu	37	chr1	209964141	209964141	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcatgggacccaggtccccAtagaagagtcggcagccctg	14	13	0	2	rs41303263	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:209964141A>G	uc001hhq.1	-	7	1022	c.759T>C	c.(757-759)TAT>TAC	p.Y253Y	IRF6_uc010psm.1_Silent_p.Y158Y|IRF6_uc009xct.1_Silent_p.Y253Y	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	253					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CCAGGTCCCCATAGAAGAGTC	0.567										HNSCC(57;0.16)			0	0	0	1	0	6	74										G	209964141	A	G	209964141	2	3	68	1	0	0	0	0	0	0	0	1	7834	224	8	5		5	IRF6	1	209964141	Silent	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2023155	209964141	39286480	119	20639										
TATDN3	128387	broad.mit.edu	37	chr1	212965324	212965324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acctctccgccccggactttGaccgcgtatgtgagggcgat	12	14	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:212965324G>C	uc001hjo.2	+	1	155	c.61G>C	c.(61-63)GAC>CAC	p.D21H	NSL1_uc001hjm.2_5'Flank|NSL1_uc001hjn.2_5'Flank|NSL1_uc010pti.1_5'Flank|TATDN3_uc010ptj.1_Missense_Mutation_p.D21H|TATDN3_uc010ptk.1_Missense_Mutation_p.D21H|TATDN3_uc001hjp.2_Missense_Mutation_p.D21H|TATDN3_uc010ptl.1_Missense_Mutation_p.D21H	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1	21						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)		CCCGGACTTTGACCGCGTATG	0.657													0	0	0	1	0	6	18										C	212965324	G	C	212965324	3	2	68	1	0	0	0	0	1	0	0	0	15590	1290	45	1	63	1	TATDN3	1	212965324	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3001183	212965324	36285297	120	20640										
CENPF	1063	broad.mit.edu	37	chr1	214813365	214813365	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aactgaagcttgctgtggctGatctggaaaagcagcgagat	13	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:214813365G>C	uc001hkm.2	+	12	1858	c.1684G>C	c.(1684-1686)GAT>CAT	p.D562H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	562	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGCTGTGGCTGATCTGGAAAA	0.363													0	0	0	1	0	39	146										C	214813365	G	C	214813365	3	2	68	1	0	0	0	0	1	0	0	0	3231	1290	45	1	1726	1	CENPF	1	214813365	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1848041	214813365	34437256	121	20641										
CENPF	1063	broad.mit.edu	37	chr1	214826227	214826227	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acttctaaagaagaatgtctCagttcacagaagctggagat	9	7	3	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:214826227C>A	uc001hkm.2	+	16	8391	c.8217C>A	c.(8215-8217)CTC>CTA	p.L2739L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2835	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGAATGTCTCAGTTCACAGA	0.328													1	0	8.00594e-06	1	8.41325e-06	17	72										A	214826227	C	A	214826227	2	1	68	1	0	0	0	0	0	0	0	1	3231	813	29	3		3	CENPF	1	214826227	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	12862	214826227	34424394	122	20642										
TP53BP2	7159	broad.mit.edu	37	chr1	223983917	223983917	+	Nonsense_Mutation	SNP	G	G	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagctgacttggatgggtatGatgggacagagatggtctcc							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:223983917G>T	uc010pvb.1	-	13	2616	c.2324C>A	c.(2323-2325)TCA>TAA	p.S775*	TP53BP2_uc001hod.2_Nonsense_Mutation_p.S646*|TP53BP2_uc010puz.1_Nonsense_Mutation_p.S8*|TP53BP2_uc010pva.1_Nonsense_Mutation_p.S414*	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	769					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GGATGGGTATGATGGGACAGA	0.478													1	0	6.12954e-19	1	7.0211e-19	25	126										T	223983917	G	T	223983917	4	4	68	1	0	0	0	0	0	1	0	0	16381	1294	45	3	1104	3	TP53BP2	1	223983917	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9157690	223983917	25266704	123	20643	106	2								
TP53BP2	7159	broad.mit.edu	37	chr1	223983926	223983926	+	Missense_Mutation	SNP	G	G	C													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggatgggtatgatgggacaGagatggtctccatggccgct							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:223983926G>C	uc010pvb.1	-	13	2607	c.2315C>G	c.(2314-2316)TCT>TGT	p.S772C	TP53BP2_uc001hod.2_Missense_Mutation_p.S643C|TP53BP2_uc010puz.1_Missense_Mutation_p.S5C|TP53BP2_uc010pva.1_Missense_Mutation_p.S411C	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	766					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		TGATGGGACAGAGATGGTCTC	0.468													0	0	0	1	0	25	115										C	223983926	G	C	223983926	3	2	68	1	0	0	0	0	1	0	0	0	16381	942	33	1	1113	1	TP53BP2	1	223983926	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9	223983926	25266695	124	20644	106	2								
OBSCN	84033	broad.mit.edu	37	chr1	228495976	228495976	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgacagaggtggctgtgcggGatggccgcatccacaccctg	15	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:228495976G>T	uc009xez.1	+	47	12675	c.12631G>T	c.(12631-12633)GAT>TAT	p.D4211Y	OBSCN_uc001hsn.2_Missense_Mutation_p.D4211Y	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4211	Ig-like 43.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGCTGTGCGGGATGGCCGCAT	0.632													1	0	4.36969e-10	1	4.83815e-10	13	16										T	228495976	G	T	228495976	3	4	68	1	0	0	0	0	1	0	0	0	10812	1174	41	3	12813	3	OBSCN	1	228495976	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4512050	228495976	20754645	125	20645										
EXOC8	149371	broad.mit.edu	37	chr1	231472148	231472148	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tagagtaaagtggcaccttcGatgcgaagctgacgaattgc	12	8	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:231472148G>A	uc001huq.2	-	1	1431	c.1344C>T	c.(1342-1344)ATC>ATT	p.I448I		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	448					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TGGCACCTTCGATGCGAAGCT	0.488													0	0	0	1	0	15	67										A	231472148	G	A	231472148	2	1	68	1	0	0	0	0	0	0	0	1	5311	1048	37	1		1	EXOC8	1	231472148	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2976172	231472148	17778473	126	20646										
EXOC8	149371	broad.mit.edu	37	chr1	231473029	231473029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtgcgctgctttccttcctCgcctggaccggagccgtcgc	12	16	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:231473029C>T	uc001huq.2	-	1	550	c.463G>A	c.(463-465)GAG>AAG	p.E155K		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	155					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				TTTCCTTCCTCGCCTGGACCG	0.677													0	0	0	1	0	12	19										T	231473029	C	T	231473029	3	4	68	1	0	0	0	0	1	0	0	0	5311	893	31	1	1718	1	EXOC8	1	231473029	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	881	231473029	17777592	127	20647										
HEATR1	55127	broad.mit.edu	37	chr1	236744562	236744562	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttggtgtttacactgtgtCttctgagaagaaagcattgc	11	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:236744562C>T	uc001hyd.1	-	20	2840	c.2715G>A	c.(2713-2715)AAG>AAA	p.K905K	HEATR1_uc009xgh.1_Silent_p.K148K	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	905					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TACACTGTGTCTTCTGAGAAG	0.408													0	0	0	1	0	25	107										T	236744562	C	T	236744562	2	4	68	1	0	0	0	0	0	0	0	1	7027	912	32	1		1	HEATR1	1	236744562	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5271533	236744562	12506059	128	20648										
RYR2	6262	broad.mit.edu	37	chr1	237872849	237872849	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atggtggctgaagtgtttatCtactggtcgaagtcccatgt	12	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr1:237872849C>T	uc001hyl.1	+	70	10332	c.10212C>T	c.(10210-10212)ATC>ATT	p.I3404I	RYR2_uc010pxz.1_Silent_p.I359I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3404					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGTGTTTATCTACTGGTCGA	0.453													0	0	0	1	0	5	13										T	237872849	C	T	237872849	2	4	68	1	0	0	0	0	0	0	0	1	13769	903	32	1		1	RYR2	1	237872849	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1128287	237872849	11377772	129	20649										
TPO	7173	broad.mit.edu	37	chr2	1500420	1500420	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atggggactttgtgcactgtGaggagtctgggaggcgcgtg	19	6	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:1500420G>A	uc002qww.2	+	13	2360	c.2269G>A	c.(2269-2271)GAG>AAG	p.E757K	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.E700K|TPO_uc002qwr.2_Missense_Mutation_p.E757K|TPO_uc002qwx.2_Missense_Mutation_p.E700K|TPO_uc010yio.1_Missense_Mutation_p.E584K|TPO_uc010yip.1_Missense_Mutation_p.E757K|TPO_uc002qwy.1_Missense_Mutation_p.E97K|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	757	Extracellular (Potential).|Sushi.				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGTGCACTGTGAGGAGTCTGG	0.547													0	0	0	1	0	45	83										A	1500420	G	A	1500420	3	1	68	1	0	0	0	0	1	0	0	0	16407	1291	45	1	2315	1	TPO	2	1500420	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		1500420	241698953	130	20650										
RNASEH1	246243	broad.mit.edu	37	chr2	3596688	3596688	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgtctgccgcccaggaagtCtaatgcctacatttctgttt	8	11	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:3596688C>A	uc002qxt.2	-	5	614	c.524G>T	c.(523-525)AGA>ATA	p.R175I	RNASEH1_uc002qxs.2_Missense_Mutation_p.R58I	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1	175	RNase H.				RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		CCCAGGAAGTCTAATGCCTAC	0.328													1	0	7.38237e-10	1	8.16662e-10	28	218										A	3596688	C	A	3596688	3	1	68	1	0	0	0	0	1	0	0	0	13411	913	32	3	352	3	RNASEH1	2	3596688	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2096268	3596688	239602685	131	20651										
RSAD2	91543	broad.mit.edu	37	chr2	7018251	7018251	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccccttgaggaagcaaagaGaggattgcttttgcttaagg	13	7	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:7018251G>A	uc002qyp.1	+	1	456	c.320G>A	c.(319-321)AGA>AAA	p.R107K		NM_080657	NP_542388	Q8WXG1	RSAD2_HUMAN	radical S-adenosyl methionine domain containing	107					defense response to virus	endoplasmic reticulum membrane|Golgi apparatus	catalytic activity|iron-sulfur cluster binding|metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			OV - Ovarian serous cystadenocarcinoma(76;0.191)		GAAGCAAAGAGAGGATTGCTT	0.507													0	0	0	1	0	17	30										A	7018251	G	A	7018251	3	1	68	1	0	0	0	0	1	0	0	0	13695	942	33	1	322	1	RSAD2	2	7018251	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3421563	7018251	236181122	132	20652										
IAH1	285148	broad.mit.edu	37	chr2	9628347	9628347	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaatttttgttctcgcatctCtggcctttgatagagaaaaa	8	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:9628347C>T	uc002qzr.2	+	6	662	c.636C>T	c.(634-636)CTC>CTT	p.L212L	IAH1_uc002qzs.2_Silent_p.L99L|IAH1_uc002qzt.2_Silent_p.L99L|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	212					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TCTCGCATCTCTGGCCTTTGA	0.428													0	0	0	1	0	12	79										T	9628347	C	T	9628347	2	4	68	1	0	0	0	0	0	0	0	1	7471	900	32	1		1	IAH1	2	9628347	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2610096	9628347	233571026	133	20653										
ODC1	4953	broad.mit.edu	37	chr2	10582001	10582001	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtatgcaattaaatgatccaTagacgccatcattcacataa	5	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:10582001T>C	uc010exg.1	-	10	1402	c.968A>G	c.(967-969)TAT>TGT	p.Y323C	ODC1_uc002ran.1_Missense_Mutation_p.Y9C|ODC1_uc002rao.1_Missense_Mutation_p.Y323C|ODC1_uc010yjd.1_Missense_Mutation_p.Y193C	NM_002539	NP_002530	P11926	DCOR_HUMAN	ornithine decarboxylase 1	323					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	AAATGATCCATAGACGCCATC	0.383													0	0	0	1	0	35	168										C	10582001	T	C	10582001	3	2	68	1	0	0	0	0	1	0	0	0	10825	1406	49	5	429	5	ODC1	2	10582001	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	953654	10582001	232617372	134	20654										
PQLC3	130814	broad.mit.edu	37	chr2	11295764	11295764	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatctccgctgtgctagcggCgcgcagcgcgcggggcctca	16	15	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:11295764C>T	uc002rbc.2	+	1	225	c.92C>T	c.(91-93)GCG>GTG	p.A31V	PQLC3_uc010yjk.1_Missense_Mutation_p.A31V	NM_152391	NP_689604	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3 precursor	31						integral to membrane					0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)		GTGCTAGCGGCGCGCAGCGCG	0.721													0	0	0	1	0	3	3										T	11295764	C	T	11295764	3	4	68	1	0	0	0	0	1	0	0	0	12420	768	27	2	94	2	PQLC3	2	11295764	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	713763	11295764	231903609	135	20655										
MATN3	4148	broad.mit.edu	37	chr2	20205794	20205794	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaggcttcgtccattgctgtCtggatggctaggcctgacat	12	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:20205794C>A	uc002rdl.2	-	2	564	c.501G>T	c.(499-501)CAG>CAT	p.Q167H	MATN3_uc010exu.1_Missense_Mutation_p.Q167H	NM_002381	NP_002372	O15232	MATN3_HUMAN	matrilin 3 precursor	167	VWFA.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCATTGCTGTCTGGATGGCTA	0.567													1	0	2.32078e-09	1	2.5472e-09	14	52										A	20205794	C	A	20205794	3	1	68	1	0	0	0	0	1	0	0	0	9335	912	32	3	987	3	MATN3	2	20205794	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	8910030	20205794	222993579	136	20656										
RHOB	388	broad.mit.edu	37	chr2	20647712	20647712	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacctcgagtgctctgccaaGaccaaggaaggcgtgcgcga	13	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:20647712G>C	uc002rdv.2	+	1	878	c.486G>C	c.(484-486)AAG>AAC	p.K162N		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	162					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTGCCAAGACCAAGGAAG	0.667													0	0	0	1	0	19	126										C	20647712	G	C	20647712	3	2	68	1	0	0	0	0	1	0	0	0	13332	933	33	1	488	1	RHOB	2	20647712	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	441918	20647712	222551661	137	20657										
OTOF	9381	broad.mit.edu	37	chr2	26706399	26706399	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttttcaccgatgaaagccttCtttacattggccatgaggct	8	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:26706399C>G	uc002rhk.2	-	13	1450	c.1323G>C	c.(1321-1323)AAG>AAC	p.K441N		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	441	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAAAGCCTTCTTTACATTGG	0.567													0	0	0	1	0	17	62										G	26706399	C	G	26706399	3	3	68	1	0	0	0	0	1	0	0	0	11303	912	32	1	5135	1	OTOF	2	26706399	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6058687	26706399	216492974	138	20658										
C2orf70	339778	broad.mit.edu	37	chr2	26800472	26800472	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatgcccgtgagggagccggAacggtaccccctccccaccg	13	17	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:26800472A>T	uc010eyn.2	+	3	437	c.437A>T	c.(436-438)GAA>GTA	p.E146V		NM_001105519	NP_001098989	A6NJV1	CB070_HUMAN	hypothetical protein LOC339778	146										skin(1)	1						AGGGAGCCGGAACGGTACCCC	0.597											OREG0014506	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	8	52										T	26800472	A	T	26800472	3	4	68	1	0	0	0	0	1	0	0	0	2190	246	9	5	447	5	C2orf70	2	26800472	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	94073	26800472	216398901	139	20659										
EIF2B4	8890	broad.mit.edu	37	chr2	27589789	27589789	+	Nonsense_Mutation	SNP	G	G	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagcctcctgaagaattcgtGataccagagatgagctagag							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:27589789G>T	uc002rkb.2	-	11	1171	c.1028C>A	c.(1027-1029)TCA>TAA	p.S343*	EIF2B4_uc002rjz.2_Nonsense_Mutation_p.S363*|EIF2B4_uc002rka.2_Nonsense_Mutation_p.S328*|EIF2B4_uc002rkc.2_Nonsense_Mutation_p.S342*|EIF2B4_uc002rkd.2_Nonsense_Mutation_p.S137*|EIF2B4_uc002rke.2_Nonsense_Mutation_p.S312*|EIF2B4_uc002rkf.1_3'UTR	NM_001034116	NP_001029288	Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B,	343					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGAATTCGTGATACCAGAGA	0.502													1	0	2.01872e-29	1	2.3357e-29	41	273										T	27589789	G	T	27589789	4	4	68	1	0	0	0	0	0	1	0	0	5003	1294	45	3	555	3	EIF2B4	2	27589789	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	789317	27589789	215609584	140	20660	107	2								
EIF2B4	8890	broad.mit.edu	37	chr2	27589796	27589796	+	Missense_Mutation	SNP	G	G	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgaagaattcgtgataccaGagatgagctagagtgaatga					rs145468921	by1000genomes	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:27589796G>T	uc002rkb.2	-	11	1164	c.1021C>A	c.(1021-1023)CTG>ATG	p.L341M	EIF2B4_uc002rjz.2_Missense_Mutation_p.L361M|EIF2B4_uc002rka.2_Missense_Mutation_p.L326M|EIF2B4_uc002rkc.2_Missense_Mutation_p.L340M|EIF2B4_uc002rkd.2_Missense_Mutation_p.L135M|EIF2B4_uc002rke.2_Missense_Mutation_p.L310M|EIF2B4_uc002rkf.1_3'UTR	NM_001034116	NP_001029288	Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B,	341					myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTGATACCAGAGATGAGCTA	0.502													1	0	6.61955e-31	1	7.67307e-31	37	271										T	27589796	G	T	27589796	3	4	68	1	0	0	0	0	1	0	0	0	5003	933	33	3	562	3	EIF2B4	2	27589796	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7	27589796	215609577	141	20661	107	2								
NRBP1	29959	broad.mit.edu	37	chr2	27656634	27656634	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggaatgaggtacagttctCtgaacgcaagaactacaagc	11	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:27656634C>G	uc002rko.2	+	4	1137	c.305C>G	c.(304-306)TCT>TGT	p.S102C	NRBP1_uc002rkq.2_Missense_Mutation_p.S102C|NRBP1_uc002rkp.2_Missense_Mutation_p.S102C|NRBP1_uc002rkr.2_5'Flank	NM_013392	NP_037524	Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein	102	Protein kinase.				ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			ovary(2)|lung(1)	3	Acute lymphoblastic leukemia(172;0.155)					GTACAGTTCTCTGAACGCAAG	0.478													0	0	0	1	0	35	57										G	27656634	C	G	27656634	3	3	68	1	0	0	0	0	1	0	0	0	10642	913	32	1	311	1	NRBP1	2	27656634	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	66838	27656634	215542739	142	20662										
GPN1	11321	broad.mit.edu	37	chr2	27864120	27864120	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttacagggagtatcgtcctGaatatgaacgtctgaaaaaa	9	6	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:27864120G>A	uc010ymc.1	+	11	877	c.856G>A	c.(856-858)GAA>AAA	p.E286K	GPN1_uc010ezf.2_Missense_Mutation_p.E260K|GPN1_uc010yma.1_Missense_Mutation_p.E193K|GPN1_uc010ymb.1_Missense_Mutation_p.E177K|GPN1_uc010ymd.1_Missense_Mutation_p.E167K|GPN1_uc010yme.1_Intron|GPN1_uc010ezg.1_Missense_Mutation_p.E167K	NM_007266	NP_009197	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1 isoform a	272						cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0						GTATCGTCCTGAATATGAACG	0.373													0	0	0	1	0	29	61										A	27864120	G	A	27864120	3	1	68	1	0	0	0	0	1	0	0	0	6617	1291	45	1	981	1	GPN1	2	27864120	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	207486	27864120	215335253	143	20663										
SLC4A1AP	22950	broad.mit.edu	37	chr2	27908000	27908000	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggaagaggaagaggaagaaGagaaagaaaaggaggagcat	17	1	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:27908000G>T	uc002rlk.3	+	10	2254	c.1972G>T	c.(1972-1974)GAG>TAG	p.E658*		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	658	Glu-rich.					cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					agaggaagaagagaaagaaaa	0.363													1	0	9.80776e-20	1	1.12446e-19	30	88										T	27908000	G	T	27908000	4	4	68	1	0	0	0	0	0	1	0	0	14653	943	33	3	2010	3	SLC4A1AP	2	27908000	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	43880	27908000	215291373	144	20664										
SPDYA	245711	broad.mit.edu	37	chr2	29052060	29052060	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgaagaagaaaccaagtacGaaatttttccatgggcttta	8	6	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:29052060G>A	uc002rmj.2	+	6	633	c.427G>A	c.(427-429)GAA>AAA	p.E143K	SPDYA_uc002rmi.2_Missense_Mutation_p.E143K|SPDYA_uc002rmk.2_Missense_Mutation_p.E143K|SPDYA_uc002rml.2_Missense_Mutation_p.E143K	NM_182756	NP_877433	Q5MJ70	SPDYA_HUMAN	speedy homolog A isoform 1	143	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			upper_aerodigestive_tract(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					AACCAAGTACGAAATTTTTCC	0.279													0	0	0	1	0	11	65										A	29052060	G	A	29052060	3	1	68	1	0	0	0	0	1	0	0	0	15026	1059	37	1	441	1	SPDYA	2	29052060	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1144060	29052060	214147313	145	20665										
BIRC6	57448	broad.mit.edu	37	chr2	32617216	32617216	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcaagctggattttatcatCaggtaaaaaaagaatataaa	6	5	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:32617216C>G	uc010ezu.2	+	5	1083	c.949C>G	c.(949-951)CAG>GAG	p.Q317E		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	317	BIR.				anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATTTTATCATCAGGTAAAAAA	0.368													0	0	0	1	0	3	12										G	32617216	C	G	32617216	3	3	68	1	0	0	0	0	1	0	0	0	1438	827	29	1	967	1	BIRC6	2	32617216	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3565156	32617216	210582157	146	20666										
VIT	5212	broad.mit.edu	37	chr2	37035867	37035867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agatttccgacacggacacgCgcatcggggccgtgcagtac	13	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:37035867C>T	uc002rpl.2	+	15	1863	c.1642C>T	c.(1642-1644)CGC>TGC	p.R548C	VIT_uc002rpm.2_Missense_Mutation_p.R526C|VIT_uc010ezv.2_Missense_Mutation_p.R504C|VIT_uc010ezw.2_Missense_Mutation_p.R505C	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	533	VWFA 2.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CACGGACACGCGCATCGGGGC	0.587													0	0	0	1	0	14	91										T	37035867	C	T	37035867	3	4	68	1	0	0	0	0	1	0	0	0	17168	768	27	2	1821	2	VIT	2	37035867	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4418651	37035867	206163506	147	20667										
VIT	5212	broad.mit.edu	37	chr2	37041503	37041503	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caactcacagcctcggaactGaattcagagcaggcagagca	10	12	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:37041503G>A	uc002rpl.2	+	16	2302	c.2081G>A	c.(2080-2082)TGA>TAA	p.*694*	VIT_uc002rpm.2_Silent_p.*672*|VIT_uc010ezv.2_Silent_p.*650*|VIT_uc010ezw.2_Silent_p.*651*	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	694						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				CCTCGGAACTGAATTCAGAGC	0.517													0	0	0	1	0	28	37										A	37041503	G	A	37041503	2	1	68	1	0	0	0	0	0	0	0	1	17168	1285	45	1		1	VIT	2	37041503	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5636	37041503	206157870	148	20668										
SULT6B1	391365	broad.mit.edu	37	chr2	37402322	37402322	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttaacattgtcgccatcaaGatgtttgttccaattgattg	7	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:37402322G>C	uc002rpu.2	-	5	484	c.463C>G	c.(463-465)CTT>GTT	p.L155V	SULT6B1_uc010yni.1_Intron	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member	193						cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				TCGCCATCAAGATGTTTGTTC	0.313													0	0	0	1	0	8	48										C	37402322	G	C	37402322	3	2	68	1	0	0	0	0	1	0	0	0	15381	942	33	1	346	1	SULT6B1	2	37402322	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	360819	37402322	205797051	149	20669										
SULT6B1	391365	broad.mit.edu	37	chr2	37410658	37410658	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatggaaagcctttcattctCttaaaaatatacacaaaaag	5	7	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:37410658C>G	uc002rpu.2	-	3	220	c.199_splice	c.e3-1	p.R67_splice	SULT6B1_uc010yni.1_Splice_Site	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member							cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				CTTTCATTCTCTTAAAAATAT	0.328													0	0	0	1	0	19	47										G	37410658	C	G	37410658	5	3	68	1	0	0	0	0	0	0	1	0	15381	927	32	1	619	1	SULT6B1	2	37410658	Splice_Site	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	8336	37410658	205788715	150	20670										
PRKD3	23683	broad.mit.edu	37	chr2	37516589	37516589	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatacatttgacagacgtctCtttcttactccactacagtt	5	11	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:37516589C>G	uc002rqd.2	-	4	1182	c.627G>C	c.(625-627)AAG>AAC	p.K209N	PRKD3_uc002rqf.1_Missense_Mutation_p.K209N	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	209					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				ACAGACGTCTCTTTCTTACTC	0.398													0	0	0	1	0	32	70										G	37516589	C	G	37516589	3	3	68	1	0	0	0	0	1	0	0	0	12520	912	32	1	2105	1	PRKD3	2	37516589	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	105931	37516589	205682784	151	20671										
CYP1B1	1545	broad.mit.edu	37	chr2	38302448	38302448	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acatgcacagtggccagcacCgacaggagtagcaggagcgt	14	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:38302448C>T	uc002rqo.2	-	3	487	c.84G>A	c.(82-84)TCG>TCA	p.S28S		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	28			S -> W (in POAG).		visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	TGGCCAGCACCGACAGGAGTA	0.682													0	0	0	1	0	5	13										T	38302448	C	T	38302448	2	4	68	1	0	0	0	0	0	0	0	1	4151	639	23	2		2	CYP1B1	2	38302448	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	785859	38302448	204896925	152	20672										
ABCG5	64240	broad.mit.edu	37	chr2	44041638	44041638	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caagtgaaattcagtccgtaGaactcattgactacaagaat	7	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:44041638G>A	uc002rtn.2	-	12	1880	c.1740C>T	c.(1738-1740)TTC>TTT	p.F580F	ABCG5_uc002rtm.2_Silent_p.F185F|ABCG5_uc002rto.2_Silent_p.F409F|ABCG5_uc002rtp.2_Silent_p.F185F	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	580	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCAGTCCGTAGAACTCATTGA	0.308													0	0	0	1	0	9	56										A	44041638	G	A	44041638	2	1	68	1	0	0	0	0	0	0	0	1	71	933	33	1		1	ABCG5	2	44041638	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5739190	44041638	199157735	153	20673										
MSH6	2956	broad.mit.edu	37	chr2	48027189	48027189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctctaggtggttgtgtcttCtacctcaaaaaatgccttat	8	9	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:48027189C>G	uc002rwd.3	+	4	2219	c.2067C>G	c.(2065-2067)TTC>TTG	p.F689L	MSH6_uc002rwc.2_Missense_Mutation_p.F689L|MSH6_uc010fbj.2_Missense_Mutation_p.F387L|MSH6_uc010yoi.1_Missense_Mutation_p.F559L|MSH6_uc010yoj.1_Missense_Mutation_p.F387L	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	689					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTTGTGTCTTCTACCTCAAAA	0.423			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	1	0	54	169										G	48027189	C	G	48027189	3	3	68	1	0	0	0	0	1	0	0	0	9874	912	32	1	2081	1	MSH6	2	48027189	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3985551	48027189	195172184	154	20674										
PNPT1	87178	broad.mit.edu	37	chr2	55900125	55900125	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taccaactgctgaatgccctGaattatttgttgggtatatt	8	7	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:55900125G>T	uc002rzf.2	-	9	822	c.769C>A	c.(769-771)CAG>AAG	p.Q257K	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	257					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGAATGCCCTGAATTATTTGT	0.398													1	0	1.40151e-16	1	1.59955e-16	19	134										T	55900125	G	T	55900125	3	4	68	1	0	0	0	0	1	0	0	0	12173	1299	45	3	1662	3	PNPT1	2	55900125	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7872936	55900125	187299248	155	20675										
ARHGAP25	9938	broad.mit.edu	37	chr2	69053293	69053293	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaagaagtcaaggaatttgtCaaatccatgaaggaacccaa	9	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:69053293C>G	uc002seu.2	+	11	2269	c.1905C>G	c.(1903-1905)GTC>GTG	p.V635V	ARHGAP25_uc010fdg.2_Silent_p.V636V|ARHGAP25_uc010yql.1_Silent_p.V596V|ARHGAP25_uc002sew.2_Silent_p.V628V|ARHGAP25_uc002sex.2_Silent_p.V629V|ARHGAP25_uc002sey.2_Silent_p.V362V	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	635	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						AGGAATTTGTCAAATCCATGA	0.552													0	0	0	1	0	12	73										G	69053293	C	G	69053293	2	3	68	1	0	0	0	0	0	0	0	1	874	813	29	1		1	ARHGAP25	2	69053293	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	13153168	69053293	174146080	156	20676										
SFXN5	94097	broad.mit.edu	37	chr2	73226123	73226123	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctcccaggtatccctggatGaacttggatgcaggtgaagg	14	9	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:73226123G>T	uc002siq.2	-	9	620	c.489C>A	c.(487-489)TTC>TTA	p.F163L	SFXN5_uc002sio.2_Missense_Mutation_p.F55L|SFXN5_uc010yrc.1_Nonsense_Mutation_p.S20*|SFXN5_uc002sip.2_Intron|SFXN5_uc010fet.2_Missense_Mutation_p.F163L	NM_144579	NP_653180	Q8TD22	SFXN5_HUMAN	sideroflexin 5	163	Helical; (Potential).				iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			ovary(1)	1						ATCCCTGGATGAACTTGGATG	0.592													1	0	5.18039e-06	1	5.46217e-06	8	32										T	73226123	G	T	73226123	3	4	68	1	0	0	0	0	1	0	0	0	14198	1281	45	3	557	3	SFXN5	2	73226123	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4172830	73226123	169973250	157	20677										
FBXO41	150726	broad.mit.edu	37	chr2	73487572	73487572	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcgccgtgagcaccagcatCtccagtcccttcaggccttc	9	17	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:73487572C>A	uc002sjb.1	-	11	2577	c.2577G>T	c.(2575-2577)GAG>GAT	p.E859D		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	798						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						GCACCAGCATCTCCAGTCCCT	0.617													1	0	6.4e-05	1	6.66446e-05	3	17										A	73487572	C	A	73487572	3	1	68	1	0	0	0	0	1	0	0	0	5750	912	32	3	245	3	FBXO41	2	73487572	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	261449	73487572	169711801	158	20678										
EGR4	1961	broad.mit.edu	37	chr2	73519500	73519500	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcgcccggaggccgggcttGacgtcgggcggggagagctg	22	11	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:73519500G>A	uc010yrj.1	-	2	930	c.855C>T	c.(853-855)GTC>GTT	p.V285V	EGR4_uc010yrk.1_Silent_p.V284V	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	181						intracellular	nucleic acid binding|zinc ion binding				0						GGCCGGGCTTGACGTCGGGCG	0.721													0	0	0	1	0	4	13										A	73519500	G	A	73519500	2	1	68	1	0	0	0	0	0	0	0	1	4974	1277	45	1		1	EGR4	2	73519500	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	31928	73519500	169679873	159	20679										
TPRKB	51002	broad.mit.edu	37	chr2	73957849	73957849	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgagataccaaattttttCaaagcctctgaaatctaaga	6	8	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:73957849C>G	uc002sjn.2	-	4	390	c.279G>C	c.(277-279)TTG>TTC	p.L93F	TPRKB_uc002sjm.2_Missense_Mutation_p.L132F|TPRKB_uc002sjl.2_Missense_Mutation_p.L60F|TPRKB_uc002sjo.2_Missense_Mutation_p.L93F|TPRKB_uc010yrm.1_Missense_Mutation_p.L60F	NM_016058	NP_057142	Q9Y3C4	TPRKB_HUMAN	TP53RK binding protein	93					protein catabolic process	cytosol|nucleus	protein kinase binding			ovary(1)|skin(1)	2						CAAATTTTTTCAAAGCCTCTG	0.308													0	0	0	1	0	9	59										G	73957849	C	G	73957849	3	3	68	1	0	0	0	0	1	0	0	0	16417	825	29	1	256	1	TPRKB	2	73957849	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	438349	73957849	169241524	160	20680										
SLC4A5	57835	broad.mit.edu	37	chr2	74466593	74466593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggaattcccaagcaggcgccCgccgtagctcagacactcct	10	16	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:74466593C>T	uc002sko.1	-	16	2190	c.2188G>A	c.(2188-2190)GGG>AGG	p.G730R	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.G730R|SLC4A5_uc010ffc.1_Missense_Mutation_p.G730R|SLC4A5_uc002skp.1_Missense_Mutation_p.G666R|SLC4A5_uc002sks.1_Missense_Mutation_p.G730R	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	730	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						AGCAGGCGCCCGCCGTAGCTC	0.537													0	0	0	1	0	32	62										T	74466593	C	T	74466593	3	4	68	1	0	0	0	0	1	0	0	0	14657	652	23	2	1269	2	SLC4A5	2	74466593	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	508744	74466593	168732780	161	20681										
MRPL53	116540	broad.mit.edu	37	chr2	74699709	74699709	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcgtacctcgtcgattccaCgtttttctcgaagggacaga	9	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:74699709C>G	uc002sln.2	-	1	219	c.79G>C	c.(79-81)GTG>CTG	p.V27L	CCDC142_uc002slo.2_RNA	NM_053050	NP_444278	Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53 precursor	27						mitochondrion|ribosome					0						GTCGATTCCACGTTTTTCTCG	0.592													0	0	0	1	0	13	80										G	74699709	C	G	74699709	3	3	68	1	0	0	0	0	1	0	0	0	9817	536	19	4	271	4	MRPL53	2	74699709	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	233116	74699709	168499664	162	20682										
LBX2	85474	broad.mit.edu	37	chr2	74725193	74725193	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccggggacaacgcgcgtagcGaggcgacgtcggcgcgcatc	17	14	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:74725193G>A	uc002slv.3	-	2	463	c.458C>T	c.(457-459)TCG>TTG	p.S153L	LBX2_uc002slw.2_Missense_Mutation_p.S149L	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	153						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGCGCGTAGCGAGGCGACGTC	0.692													0	0	0	1	0	21	60										A	74725193	G	A	74725193	3	1	68	1	0	0	0	0	1	0	0	0	8654	1059	37	1	142	1	LBX2	2	74725193	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	25484	74725193	168474180	163	20683										
DQX1	165545	broad.mit.edu	37	chr2	74749805	74749805	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caggggccagagggaattctGatagtatgacacccagatct	12	9	2	4	rs145468372		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:74749805G>C	uc010yrw.1	-	8	1562	c.1397C>G	c.(1396-1398)TCA>TGA	p.S466*	DQX1_uc002smc.2_Nonsense_Mutation_p.S27*	NM_133637	NP_598376	Q8TE96	DQX1_HUMAN	DEAQ box polypeptide 1 (RNA-dependent ATPase)	466						nucleus	ATP binding|helicase activity|nucleic acid binding			ovary(2)	2						AGGGAATTCTGATAGTATGAC	0.557													0	0	0	1	0	34	200										C	74749805	G	C	74749805	4	2	68	1	0	0	0	0	0	1	0	0	4751	1294	45	1	776	1	DQX1	2	74749805	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	24612	74749805	168449568	164	20684										
LOXL3	84695	broad.mit.edu	37	chr2	74763222	74763222	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcttgtgggggcacttccaGagggagagctcctgtccaga	14	10	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:74763222G>C	uc002smp.1	-	7	1221	c.1149C>G	c.(1147-1149)CTC>CTG	p.L383L	LOXL3_uc002smo.1_Silent_p.L22L|LOXL3_uc010ffm.1_Silent_p.L383L|LOXL3_uc002smq.1_Silent_p.L238L|LOXL3_uc010ffn.1_Silent_p.L238L	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	383	SRCR 3.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						GGCACTTCCAGAGGGAGAGCT	0.542													0	0	0	1	0	18	101										C	74763222	G	C	74763222	2	2	68	1	0	0	0	0	0	0	0	1	8901	929	33	1		1	LOXL3	2	74763222	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	13417	74763222	168436151	165	20685										
LRRTM1	347730	broad.mit.edu	37	chr2	80530006	80530006	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgcccgcaatcccacaggttCccggccagggtgatgcttgt	12	15	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:80530006C>T	uc002sok.1	-	2	1209	c.939G>A	c.(937-939)GGG>GGA	p.G313G	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	313	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CCCACAGGTTCCCGGCCAGGG	0.632										HNSCC(69;0.2)			0	0	0	1	0	18	35										T	80530006	C	T	80530006	2	4	68	1	0	0	0	0	0	0	0	1	9039	842	30	1		1	LRRTM1	2	80530006	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5766784	80530006	162669367	166	20686										
RPIA	22934	broad.mit.edu	37	chr2	88999546	88999546	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgaaagggtgaagcaagaGaatctgaacctcgtctgtat	12	7	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:88999546G>C	uc002ste.2	+	3	407	c.366G>C	c.(364-366)GAG>GAC	p.E122D		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	122					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				TGAAGCAAGAGAATCTGAACC	0.453													0	0	0	1	0	11	95										C	88999546	G	C	88999546	3	2	68	1	0	0	0	0	1	0	0	0	13553	933	33	1	376	1	RPIA	2	88999546	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8469540	88999546	154199827	167	20687										
VWA3B	200403	broad.mit.edu	37	chr2	98844712	98844712	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaaatggaacagggtcacagTgatctggagaagatgcaaga	14	5	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:98844712T>G	uc002syo.2	+	15	2331	c.2067T>G	c.(2065-2067)AGT>AGG	p.S689R	VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.S208R|VWA3B_uc002sym.2_Missense_Mutation_p.S689R|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.S346R|VWA3B_uc002syp.1_Missense_Mutation_p.S81R|VWA3B_uc002syq.1_Intron|VWA3B_uc002syr.1_Missense_Mutation_p.S6R	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	689										ovary(3)|large_intestine(2)|skin(1)	6						AGGGTCACAGTGATCTGGAGA	0.418													0	0	0	1	0	20	88										G	98844712	T	G	98844712	3	3	68	1	0	0	0	0	1	0	0	0	17238	1693	59	5	2121	5	VWA3B	2	98844712	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	9845166	98844712	144354661	168	20688										
IL18RAP	8807	broad.mit.edu	37	chr2	103068601	103068601	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggaaaggactcagtagaaCagaaaccactgggaggagct	14	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:103068601C>G	uc002tbx.2	+	12	2244	c.1760C>G	c.(1759-1761)ACA>AGA	p.T587R	IL18RAP_uc010fiz.2_Missense_Mutation_p.T445R	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	587	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						CTCAGTAGAACAGAAACCACT	0.507													0	0	0	1	0	28	108										G	103068601	C	G	103068601	3	3	68	1	0	0	0	0	1	0	0	0	7648	478	17	4	1798	4	IL18RAP	2	103068601	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4223889	103068601	140130772	169	20689										
PTPN4	5775	broad.mit.edu	37	chr2	120703971	120703971	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taatcagaatgaaacctgatGaaaatgggaggtttggattc	11	4	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:120703971G>A	uc002tmf.1	+	17	2341	c.1570G>A	c.(1570-1572)GAA>AAA	p.E524K	PTPN4_uc010flj.1_Missense_Mutation_p.E237K|PTPN4_uc010yyr.1_Missense_Mutation_p.E157K	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	524	PDZ.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	GAAACCTGATGAAAATGGGAG	0.269													0	0	0	1	0	21	79										A	120703971	G	A	120703971	3	1	68	1	0	0	0	0	1	0	0	0	12790	1291	45	1	1632	1	PTPN4	2	120703971	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	17635370	120703971	122495402	170	20690										
CLASP1	23332	broad.mit.edu	37	chr2	122145474	122145474	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacagagagattagcacaatCtgtgctgcctagaaaaagga	10	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:122145474C>A	uc002tnc.2	-	30	3522	c.3132G>T	c.(3130-3132)CAG>CAT	p.Q1044H	CLASP1_uc010yyv.1_Missense_Mutation_p.Q129H|CLASP1_uc002tmz.2_Missense_Mutation_p.Q129H|CLASP1_uc002tna.2_Missense_Mutation_p.Q129H|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.Q1024H|CLASP1_uc010yza.1_Missense_Mutation_p.Q1016H|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tnf.2_5'UTR	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1044					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TTAGCACAATCTGTGCTGCCT	0.333													1	0	8.12818e-05	1	8.44313e-05	7	33										A	122145474	C	A	122145474	3	1	68	1	0	0	0	0	1	0	0	0	3454	912	32	3	1524	3	CLASP1	2	122145474	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1441503	122145474	121053899	171	20691										
ERCC3	2071	broad.mit.edu	37	chr2	128018835	128018835	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaccttgatctaccaagaatCtctgccgcttggttgagtaa	8	10	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:128018835C>T	uc002toh.1	-	13	2128	c.2033G>A	c.(2032-2034)AGA>AAA	p.R678K	ERCC3_uc002toe.1_Missense_Mutation_p.R433K|ERCC3_uc002tof.1_Missense_Mutation_p.R614K|ERCC3_uc002tog.1_Missense_Mutation_p.R614K	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	678	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TACCAAGAATCTCTGCCGCTT	0.463			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	13	38										T	128018835	C	T	128018835	3	4	68	1	0	0	0	0	1	0	0	0	5214	913	32	1	327	1	ERCC3	2	128018835	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5873361	128018835	115180538	172	20692										
NCKAP5	344148	broad.mit.edu	37	chr2	133541789	133541789	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttgggcggaatgttttggAatgtgtggatctgatcgtaa	15	3	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:133541789A>G	uc002ttp.2	-	14	2969	c.2595T>C	c.(2593-2595)ATT>ATC	p.I865I	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	865							protein binding				0						AATGTTTTGGAATGTGTGGAT	0.542													0	0	0	1	0	23	84										G	133541789	A	G	133541789	2	3	68	1	0	0	0	0	0	0	0	1	10223	242	9	5		5	NCKAP5	2	133541789	Silent	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	5522954	133541789	109657584	173	20693										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135908057	135908057	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagagtgcctgtctgctctCagatatggagtcttttaagg	12	8	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:135908057C>T	uc002tuj.2	+	18	2067	c.2042C>T	c.(2041-2043)TCA>TTA	p.S681L	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.S681L|RAB3GAP1_uc010fng.2_Missense_Mutation_p.S506L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	681						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TGTCTGCTCTCAGATATGGAG	0.468													0	0	0	1	0	4	42										T	135908057	C	T	135908057	3	4	68	1	0	0	0	0	1	0	0	0	12935	838	29	1	2112	1	RAB3GAP1	2	135908057	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2366268	135908057	107291316	174	20694										
NR4A2	4929	broad.mit.edu	37	chr2	157186448	157186448	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taatggaggactgctgtccgGacaggggcatttggtacaag	15	7	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:157186448G>A	uc002tyz.3	-	3	673	c.251C>T	c.(250-252)TCC>TTC	p.S84F	NR4A2_uc002tyx.3_Missense_Mutation_p.S21F|NR4A2_uc010zcf.1_Missense_Mutation_p.S84F|NR4A2_uc010zcg.1_5'Flank	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	84	Gln-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						CTGCTGTCCGGACAGGGGCAT	0.542													0	0	0	1	0	17	82										A	157186448	G	A	157186448	3	1	68	1	0	0	0	0	1	0	0	0	10633	1174	41	1	1569	1	NR4A2	2	157186448	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	21278391	157186448	86012925	175	20695										
TANC1	85461	broad.mit.edu	37	chr2	160042372	160042372	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaaccgccagcagaccatgGagcttggccaccacatcctg	10	15	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:160042372G>C	uc002uag.2	+	15	2855	c.2581G>C	c.(2581-2583)GAG>CAG	p.E861Q	TANC1_uc010zcm.1_Missense_Mutation_p.E853Q|TANC1_uc010fom.1_Missense_Mutation_p.E667Q	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	861						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GCAGACCATGGAGCTTGGCCA	0.522													0	0	0	1	0	7	23										C	160042372	G	C	160042372	3	2	68	1	0	0	0	0	1	0	0	0	15541	1175	41	1	2631	1	TANC1	2	160042372	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2855924	160042372	83157001	176	20696										
SCN1A	6323	broad.mit.edu	37	chr2	166908450	166908450	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagtcaggatcattacatctGagagcttcttcacagactgg	9	10	5	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:166908450G>C	uc010zcz.1	-	6	761	c.743C>G	c.(742-744)TCA>TGA	p.S248*	SCN1A_uc002udo.3_Nonsense_Mutation_p.S117*|SCN1A_uc010fpk.2_Nonsense_Mutation_p.S117*	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	248	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CATTACATCTGAGAGCTTCTT	0.423													0	0	0	1	0	17	76										C	166908450	G	C	166908450	4	2	68	1	0	0	0	0	0	1	0	0	13914	1294	45	1	5370	1	SCN1A	2	166908450	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6866078	166908450	76290923	177	20697										
METTL5	29081	broad.mit.edu	37	chr2	170669018	170669018	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcaggtcatatcgaagttcTgtaaaacaaaagccacctaa	8	9	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:170669018T>C	uc002ufn.2	-	6	788	c.542_splice	c.e6-1	p.E181_splice	METTL5_uc002ufo.2_Splice_Site_p.E181_splice|METTL5_uc002ufp.2_Splice_Site_p.E181_splice|METTL5_uc002ufq.1_Intron	NM_014168	NP_054887	Q9NRN9	METL5_HUMAN	methyltransferase like 5								methyltransferase activity|nucleic acid binding			central_nervous_system(1)	1						ATCGAAGTTCTGTAAAACAAA	0.358													0	0	0	1	0	34	64										C	170669018	T	C	170669018	5	2	68	1	0	0	0	0	0	0	1	0	9503	1594	55	5	97	5	METTL5	2	170669018	Splice_Site	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	3760568	170669018	72530355	178	20698										
HAT1	8520	broad.mit.edu	37	chr2	172822425	172822425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgaaagatggcactactttCtagtgtaagtacagttctaa	8	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:172822425C>G	uc002uhi.2	+	6	683	c.607C>G	c.(607-609)CTA>GTA	p.L203V	HAT1_uc010fqi.2_Missense_Mutation_p.L38V|HAT1_uc002uhj.2_Missense_Mutation_p.L118V	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	203					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GCACTACTTTCTAGTGTAAGT	0.378													0	0	0	1	0	20	115										G	172822425	C	G	172822425	3	3	68	1	0	0	0	0	1	0	0	0	6964	912	32	1	629	1	HAT1	2	172822425	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2153407	172822425	70376948	179	20699										
HAT1	8520	broad.mit.edu	37	chr2	172841129	172841129	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaaagctatgtgaaattacGagactttgtgcttgtgaagc	10	6	0	3	rs140409528		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:172841129G>A	uc002uhi.2	+	9	933	c.857G>A	c.(856-858)CGA>CAA	p.R286Q	HAT1_uc010fqi.2_Missense_Mutation_p.R121Q|HAT1_uc002uhj.2_Missense_Mutation_p.R201Q	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	286					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GTGAAATTACGAGACTTTGTG	0.353													0	0	0	1	0	20	40										A	172841129	G	A	172841129	3	1	68	1	0	0	0	0	1	0	0	0	6964	1058	37	1	891	1	HAT1	2	172841129	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	18704	172841129	70358244	180	20700										
OSBPL6	114880	broad.mit.edu	37	chr2	179197760	179197760	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgctaatgtttctgtaatgGatggaaaggtatgactttgt	11	4	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:179197760G>A	uc002ulx.2	+	8	1027	c.649G>A	c.(649-651)GAT>AAT	p.D217N	OSBPL6_uc002ulw.2_Missense_Mutation_p.D217N|OSBPL6_uc002uly.2_Missense_Mutation_p.D217N|OSBPL6_uc010zfe.1_Missense_Mutation_p.D217N|OSBPL6_uc002ulz.2_Missense_Mutation_p.D217N|OSBPL6_uc002uma.2_Missense_Mutation_p.D196N	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	217					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			TTCTGTAATGGATGGAAAGGT	0.299													0	0	0	1	0	10	59										A	179197760	G	A	179197760	3	1	68	1	0	0	0	0	1	0	0	0	11281	1174	41	1	714	1	OSBPL6	2	179197760	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6356631	179197760	64001613	181	20701										
TTN	7273	broad.mit.edu	37	chr2	179603040	179603040	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtgaatttggctaggtggcCcagtgctacttccaggggtt	15	8	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:179603040C>T	uc010zfg.1	-	46	10632	c.10408G>A	c.(10408-10410)GGC>AGC	p.G3470S	TTN_uc010zfh.1_Missense_Mutation_p.G4543S|TTN_uc010zfi.1_Missense_Mutation_p.G4476S|TTN_uc010zfj.1_Missense_Mutation_p.G4351S|TTN_uc002umz.1_Missense_Mutation_p.G131S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4397							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTAGGTGGCCCAGTGCTACT	0.483													0	0	0	1	0	7	26										T	179603040	C	T	179603040	3	4	68	1	0	0	0	0	1	0	0	0	16732	623	22	2	90645	2	TTN	2	179603040	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	405280	179603040	63596333	182	20702										
TTN	7273	broad.mit.edu	37	chr2	179605533	179605533	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttgggagatggttccttgaGaggctgaaagtgaatactgc	15	5	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:179605533G>T	uc010zfh.1	-	46	12138	c.11914C>A	c.(11914-11916)CTC>ATC	p.L3972I	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.L3905I|TTN_uc010zfj.1_Missense_Mutation_p.L3780I|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTTCCTTGAGAGGCTGAAAG	0.473													1	0	1.55811e-20	1	1.78963e-20	30	119										T	179605533	G	T	179605533	3	4	68	1	0	0	0	0	1	0	0	0	16732	942	33	3	92362	3	TTN	2	179605533	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2493	179605533	63593840	183	20703										
DNAJC10	54431	broad.mit.edu	37	chr2	183582961	183582961	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaaaactgcaagcagtagaGaaataagacaagctttcaag	8	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:183582961G>A	uc002uow.1	+	3	563	c.148G>A	c.(148-150)GAA>AAA	p.E50K	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.E50K|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	50	J.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			AAGCAGTAGAGAAATAAGACA	0.338													0	0	0	1	0	18	69										A	183582961	G	A	183582961	3	1	68	1	0	0	0	0	1	0	0	0	4629	943	33	1	150	1	DNAJC10	2	183582961	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3977428	183582961	59616412	184	20704										
NCKAP1	10787	broad.mit.edu	37	chr2	183860508	183860508	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggcatttctccactggtcaGctgaaagattccttcgagga	11	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:183860508G>C	uc002upc.2	-	7	1064	c.662C>G	c.(661-663)GCT>GGT	p.A221G	NCKAP1_uc002upb.2_Missense_Mutation_p.A227G	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	221					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CCACTGGTCAGCTGAAAGATT	0.368													0	0	0	1	0	12	69										C	183860508	G	C	183860508	3	2	68	1	0	0	0	0	1	0	0	0	10221	971	34	4	2824	4	NCKAP1	2	183860508	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	277547	183860508	59338865	185	20705										
SLC40A1	30061	broad.mit.edu	37	chr2	190428686	190428686	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatgctcccatcaaaatactGaggatggaaccactcagtcc	8	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:190428686G>A	uc002uqp.3	-	7	1377	c.1026C>T	c.(1024-1026)CTC>CTT	p.L342L		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	342	Helical; (Potential).				anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TCAAAATACTGAGGATGGAAC	0.478													0	0	0	1	0	7	48										A	190428686	G	A	190428686	2	1	68	1	0	0	0	0	0	0	0	1	14628	1277	45	1		1	SLC40A1	2	190428686	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6568178	190428686	52770687	186	20706										
TMEFF2	23671	broad.mit.edu	37	chr2	193049159	193049159	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtcgcaggtaacactcattCtggtagctctccccattgga	9	12	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:193049159C>T	uc002utc.2	-	3	727	c.333G>A	c.(331-333)CAG>CAA	p.Q111Q	TMEFF2_uc002utd.1_Silent_p.Q111Q	NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	111	Kazal-like 1.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			AACACTCATTCTGGTAGCTCT	0.473													0	0	0	1	0	14	54										T	193049159	C	T	193049159	2	4	68	1	0	0	0	0	0	0	0	1	16011	912	32	1		1	TMEFF2	2	193049159	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2620473	193049159	50150214	187	20707										
DNAH7	56171	broad.mit.edu	37	chr2	196834710	196834710	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caactttccattcagtatttGagccttttttaggtaccgct	6	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:196834710G>C	uc002utj.3	-	17	2268	c.2167C>G	c.(2167-2169)CAA>GAA	p.Q723E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	723	Stem (By similarity).|Potential.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTCAGTATTTGAGCCTTTTTT	0.328													0	0	0	1	0	7	57										C	196834710	G	C	196834710	3	2	68	1	0	0	0	0	1	0	0	0	4606	1299	45	1	10103	1	DNAH7	2	196834710	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3785551	196834710	46364663	188	20708										
STK17B	9262	broad.mit.edu	37	chr2	197004437	197004437	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aataatctacattaacttgaGaaatattgaggtatgtttct	6	4	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:197004437G>C	uc002utk.2	-	7	1067	c.743C>G	c.(742-744)TCT>TGT	p.S248C	STK17B_uc010fsh.2_Missense_Mutation_p.S248C	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	248	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)			ATTAACTTGAGAAATATTGAG	0.333													0	0	0	1	0	46	74										C	197004437	G	C	197004437	3	2	68	1	0	0	0	0	1	0	0	0	15290	942	33	1	383	1	STK17B	2	197004437	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	169727	197004437	46194936	189	20709										
ANKRD44	91526	broad.mit.edu	37	chr2	197865158	197865158	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttacctgcctttgtcatctCtacaactgacgatactggaa	6	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:197865158C>G	uc002uua.1	-	23	2506	c.2429G>C	c.(2428-2430)AGA>ACA	p.R810T	ANKRD44_uc002utz.3_Missense_Mutation_p.R542T	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	835							protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTTGTCATCTCTACAACTGAC	0.378													0	0	0	1	0	7	51										G	197865158	C	G	197865158	3	3	68	1	0	0	0	0	1	0	0	0	672	913	32	1	346	1	ANKRD44	2	197865158	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	860721	197865158	45334215	190	20710										
SF3B1	23451	broad.mit.edu	37	chr2	198257807	198257807	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtctcaaatacattgggccaTacatagttcaacaagtgatt	7	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:198257807T>C	uc002uue.2	-	24	3693	c.3645A>G	c.(3643-3645)GTA>GTG	p.V1215V		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	1215					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CATTGGGCCATACATAGTTCA	0.448													0	0	0	1	0	21	54										C	198257807	T	C	198257807	2	2	68	1	0	0	0	0	0	0	0	1	14149	1393	49	5		5	SF3B1	2	198257807	Silent	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	392649	198257807	44941566	191	20711										
SF3B1	23451	broad.mit.edu	37	chr2	198274635	198274635	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtgtggctaggtgtaggatCccatatttttgagcctgggg	15	6	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:198274635C>T	uc002uue.2	-	7	811	c.763G>A	c.(763-765)GAT>AAT	p.D255N		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	255	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GGTGTAGGATCCCATATTTTT	0.572													0	0	0	1	0	26	130										T	198274635	C	T	198274635	3	4	68	1	0	0	0	0	1	0	0	0	14149	855	30	1	3227	1	SF3B1	2	198274635	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	16828	198274635	44924738	192	20712										
HSPD1	3329	broad.mit.edu	37	chr2	198358196	198358196	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actcaacagaacataggcatCctggaattcacatttctgac	6	11	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:198358196C>A	uc002uui.2	-	7	858	c.721G>T	c.(721-723)GAT>TAT	p.D241Y	HSPD1_uc002uuj.2_Missense_Mutation_p.D239Y|HSPD1_uc010zgx.1_Missense_Mutation_p.D232Y|HSPD1_uc010fsm.2_Missense_Mutation_p.D52Y|HSPD1_uc002uuk.2_Missense_Mutation_p.D241Y	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	241					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			ACATAGGCATCCTGGAATTCA	0.343													1	0	5.01169e-05	1	5.22743e-05	17	50										A	198358196	C	A	198358196	3	1	68	1	0	0	0	0	1	0	0	0	7428	855	30	3	1024	3	HSPD1	2	198358196	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	83561	198358196	44841177	193	20713										
NIF3L1	60491	broad.mit.edu	37	chr2	201761901	201761901	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaagacacctaaaactatctCatattcgcttagcccttggg	6	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:201761901C>G	uc002uwm.2	+	5	920	c.829C>G	c.(829-831)CAT>GAT	p.H277D	NIF3L1_uc002uwl.2_Missense_Mutation_p.H250D|NIF3L1_uc002uwn.2_Missense_Mutation_p.H250D|NIF3L1_uc002uwo.2_Missense_Mutation_p.H277D|NIF3L1_uc002uwp.2_Missense_Mutation_p.H277D|NIF3L1_uc002uwq.2_Intron	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	277					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						AAAACTATCTCATATTCGCTT	0.423													0	0	0	1	0	27	104										G	201761901	C	G	201761901	3	3	68	1	0	0	0	0	1	0	0	0	10416	826	29	1	843	1	NIF3L1	2	201761901	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3403705	201761901	41437472	194	20714										
ALS2CR12	130540	broad.mit.edu	37	chr2	202154187	202154187	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagcagccgcacttcagatGaatgttctcttccgtcagga	10	12	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:202154187G>A	uc010ftg.2	-	14	1648	c.1204C>T	c.(1204-1206)CAT>TAT	p.H402Y	ALS2CR12_uc002uya.3_Missense_Mutation_p.H379Y|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	402	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CACTTCAGATGAATGTTCTCT	0.433													0	0	0	1	0	21	67										A	202154187	G	A	202154187	3	1	68	1	0	0	0	0	1	0	0	0	553	1290	45	1	141	1	ALS2CR12	2	202154187	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	392286	202154187	41045186	195	20715										
CDK15	65061	broad.mit.edu	37	chr2	202700471	202700471	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggagccactgaatattcctCtgagctggacatatggtaag	12	8	1	2	rs61383268		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:202700471C>G	uc002uyt.2	+	8	885	c.836C>G	c.(835-837)TCT>TGT	p.S279C	CDK15_uc010ftm.2_Missense_Mutation_p.S144C|CDK15_uc002uys.2_Missense_Mutation_p.S228C|CDK15_uc010ftn.1_Missense_Mutation_p.S228C|CDK15_uc010fto.1_Missense_Mutation_p.S258C	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	279	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	GAATATTCCTCTGAGCTGGAC	0.468													0	0	0	1	0	17	47										G	202700471	C	G	202700471	3	3	68	1	0	0	0	0	1	0	0	0	3131	913	32	1	709	1	CDK15	2	202700471	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	546284	202700471	40498902	196	20716										
ALS2CR8	79800	broad.mit.edu	37	chr2	203831746	203831746	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagtatgggccaagaagaaAaggtttccagttaaaaaaag	10	5	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:203831746A>G	uc002uzo.2	+	9	1158	c.878A>G	c.(877-879)AAA>AGA	p.K293R	ALS2CR8_uc010zhy.1_3'UTR|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.K217R|ALS2CR8_uc010zib.1_Missense_Mutation_p.K217R|ALS2CR8_uc010zic.1_Missense_Mutation_p.K205R|ALS2CR8_uc002uzp.2_Missense_Mutation_p.K293R	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	293										large_intestine(1)|ovary(1)	2						CCAAGAAGAAAAGGTTTCCAG	0.408													0	0	0	1	0	23	122										G	203831746	A	G	203831746	3	3	68	1	0	0	0	0	1	0	0	0	555	14	1	5	904	5	ALS2CR8	2	203831746	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	1131275	203831746	39367627	197	20717										
ZDBF2	57683	broad.mit.edu	37	chr2	207169584	207169584	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agagagaccatccgaggtttCagaacctattgaagagttac	10	8	1	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:207169584C>T	uc002vbp.2	+	5	582	c.332C>T	c.(331-333)TCA>TTA	p.S111L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	111							nucleic acid binding|zinc ion binding			ovary(3)	3						TCCGAGGTTTCAGAACCTATT	0.448													0	0	0	1	0	19	28										T	207169584	C	T	207169584	3	4	68	1	0	0	0	0	1	0	0	0	17596	838	29	1	342	1	ZDBF2	2	207169584	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3337838	207169584	36029789	198	20718										
ARPC2	10109	broad.mit.edu	37	chr2	219114628	219114628	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccagatgccgagaaaaaaGaaatgaaaacaatcacgtaa	8	8	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:219114628G>C	uc002vhd.2	+	10	974	c.862G>C	c.(862-864)GAA>CAA	p.E288Q	ARPC2_uc002vhe.2_Missense_Mutation_p.E288Q|ARPC2_uc002vhf.2_Missense_Mutation_p.E174Q	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	288					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		CGAGAAAAAAGAAATGAAAAC	0.542													0	0	0	1	0	4	15										C	219114628	G	C	219114628	3	2	68	1	0	0	0	0	1	0	0	0	971	943	33	1	896	1	ARPC2	2	219114628	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11945044	219114628	24084745	199	20719										
DOCK10	55619	broad.mit.edu	37	chr2	225652012	225652012	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgaagtctcgttgtttctCaaagacagcaatgatgggct	10	7	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:225652012C>G	uc010fwz.1	-	49	5760	c.5521G>C	c.(5521-5523)GAG>CAG	p.E1841Q	DOCK10_uc002vob.2_Missense_Mutation_p.E1835Q|DOCK10_uc002voa.2_Missense_Mutation_p.E497Q|DOCK10_uc002voc.2_Missense_Mutation_p.E662Q	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1841	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CGTTGTTTCTCAAAGACAGCA	0.368													0	0	0	1	0	20	110										G	225652012	C	G	225652012	3	3	68	1	0	0	0	0	1	0	0	0	4685	835	29	1	1071	1	DOCK10	2	225652012	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6537384	225652012	17547361	200	20720										
IRS1	3667	broad.mit.edu	37	chr2	227661897	227661897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgagttctctttcggaaccGattatccagatctgcagcac	9	11	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:227661897G>A	uc002voh.3	-	1	1610	c.1558C>T	c.(1558-1560)CGG>TGG	p.R520W		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	520					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TTTCGGAACCGATTATCCAGA	0.592											OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	12	65										A	227661897	G	A	227661897	3	1	68	1	0	0	0	0	1	0	0	0	7840	1057	37	1	2174	1	IRS1	2	227661897	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2009885	227661897	15537476	201	20721										
MFF	56947	broad.mit.edu	37	chr2	228220436	228220436	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaccattgaaggaacgtcaGatgacctgactgttgtagat	10	8	1	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:228220436G>C	uc002vos.2	+	10	1274	c.856G>C	c.(856-858)GAT>CAT	p.D286H	MFF_uc002vot.2_Missense_Mutation_p.D235H|MFF_uc002vou.2_Missense_Mutation_p.D208H|MFF_uc002vov.2_Missense_Mutation_p.D182H|MFF_uc002vow.2_Missense_Mutation_p.D187H|MFF_uc002vox.2_Missense_Mutation_p.D162H|MFF_uc002voy.2_Missense_Mutation_p.D286H|MFF_uc002voz.2_Missense_Mutation_p.D162H|MFF_uc002vpa.2_Missense_Mutation_p.D74H	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	286	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						AGGAACGTCAGATGACCTGAC	0.323													0	0	0	1	0	65	104										C	228220436	G	C	228220436	3	2	68	1	0	0	0	0	1	0	0	0	9519	942	33	1	886	1	MFF	2	228220436	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	558539	228220436	14978937	202	20722										
TRIP12	9320	broad.mit.edu	37	chr2	230723948	230723948	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctctgtcctttttcttttCtgactccgtgaaccgccagt	6	14	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:230723948C>A	uc002vpw.1	-	3	550	c.441G>T	c.(439-441)CAG>CAT	p.Q147H	TRIP12_uc002vpx.1_Missense_Mutation_p.Q189H|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Missense_Mutation_p.Q147H	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	147					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TTTTTCTTTTCTGACTCCGTG	0.488													1	0	4.22769e-11	1	4.7099e-11	27	97										A	230723948	C	A	230723948	3	1	68	1	0	0	0	0	1	0	0	0	16553	912	32	3	5693	3	TRIP12	2	230723948	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2503512	230723948	12475425	203	20723										
ARMC9	80210	broad.mit.edu	37	chr2	232146826	232146826	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctttctgttccatccattCgtgaggaagcaagagcaatg	9	10	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:232146826C>T	uc002vrq.3	+	17	1718	c.1606C>T	c.(1606-1608)CGT>TGT	p.R536C	ARMC9_uc002vrp.3_Missense_Mutation_p.R536C|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	536							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TCCATCCATTCGTGAGGAAGC	0.428													0	0	0	1	0	23	76										T	232146826	C	T	232146826	3	4	68	1	0	0	0	0	1	0	0	0	958	884	31	1	1668	1	ARMC9	2	232146826	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1422878	232146826	11052547	204	20724										
CHRND	1144	broad.mit.edu	37	chr2	233398643	233398643	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccttgacatggccccagctCttcctggagaccctgccgga	10	17	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:233398643C>G	uc002vsw.2	+	10	1054	c.1050C>G	c.(1048-1050)CTC>CTG	p.L350L	CHRND_uc010zmg.1_Silent_p.L335L|CHRND_uc010fyc.2_Silent_p.L223L|CHRND_uc010zmh.1_Silent_p.L156L	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	350	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GGCCCCAGCTCTTCCTGGAGA	0.453													0	0	0	1	0	17	66										G	233398643	C	G	233398643	2	3	68	1	0	0	0	0	0	0	0	1	3394	900	32	1		1	CHRND	2	233398643	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1251817	233398643	9800730	205	20725										
CHRND	1144	broad.mit.edu	37	chr2	233399028	233399028	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacttcattgttaaccacatGagggaccagaacaattacaa	6	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:233399028G>A	uc002vsw.2	+	11	1351	c.1347G>A	c.(1345-1347)ATG>ATA	p.M449I	CHRND_uc010zmg.1_Missense_Mutation_p.M434I|CHRND_uc010fyc.2_Missense_Mutation_p.M322I|CHRND_uc010zmh.1_Missense_Mutation_p.M255I	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	449	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		TTAACCACATGAGGGACCAGA	0.502													0	0	0	1	0	12	39										A	233399028	G	A	233399028	3	1	68	1	0	0	0	0	1	0	0	0	3394	1290	45	1	1389	1	CHRND	2	233399028	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	385	233399028	9800345	206	20726										
INPP5D	3635	broad.mit.edu	37	chr2	233986856	233986856	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaggttcttcaccaagctgGaccagctcatcgagttttac	9	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:233986856G>A	uc010zmo.1	+	3	391	c.238G>A	c.(238-240)GAC>AAC	p.D80N	INPP5D_uc010zmp.1_Missense_Mutation_p.D80N	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	80	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CACCAAGCTGGACCAGCTCAT	0.522													0	0	0	1	0	12	81										A	233986856	G	A	233986856	3	1	68	1	0	0	0	0	1	0	0	0	7756	1174	41	1	248	1	INPP5D	2	233986856	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	587828	233986856	9212517	207	20727										
COL6A3	1293	broad.mit.edu	37	chr2	238280791	238280791	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctgcacttcatccttgctgGaatgggcgttcagcaggaac	11	11	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:238280791G>C	uc002vwl.2	-	9	4154	c.3869C>G	c.(3868-3870)TCC>TGC	p.S1290C	COL6A3_uc002vwo.2_Missense_Mutation_p.S1084C|COL6A3_uc010znj.1_Missense_Mutation_p.S683C|COL6A3_uc002vwq.2_Missense_Mutation_p.S1084C|COL6A3_uc002vwr.2_Missense_Mutation_p.S883C	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1290	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATCCTTGCTGGAATGGGCGTT	0.607													0	0	0	1	0	15	30										C	238280791	G	C	238280791	3	2	68	1	0	0	0	0	1	0	0	0	3701	1174	41	1	5855	1	COL6A3	2	238280791	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4293935	238280791	4918582	208	20728										
NDUFA10	4705	broad.mit.edu	37	chr2	240958025	240958025	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccaggaacacaaagtcactGaagatggagcgctccaacac	9	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:240958025G>A	uc002vyn.2	-	4	572	c.492C>T	c.(490-492)TTC>TTT	p.F164F	NDUFA10_uc010fzc.1_Silent_p.F164F|NDUFA10_uc002vyo.1_Silent_p.F164F|NDUFA10_uc002vyp.2_Silent_p.F164F	NM_004544	NP_004535	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	164					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)	1		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	CAAAGTCACTGAAGATGGAGC	0.473													0	0	0	1	0	5	39										A	240958025	G	A	240958025	2	1	68	1	0	0	0	0	0	0	0	1	10260	1281	45	1		1	NDUFA10	2	240958025	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2677234	240958025	2241348	209	20729										
ANO7	50636	broad.mit.edu	37	chr2	242157737	242157737	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacgacctgcgcggcttcctCaacttcacgctggcgcgagc	11	17	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:242157737C>T	uc002wax.2	+	21	2527	c.2424C>T	c.(2422-2424)CTC>CTT	p.L808L		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	808	Extracellular (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GCGGCTTCCTCAACTTCACGC	0.741													0	0	0	1	0	3	4										T	242157737	C	T	242157737	2	4	68	1	0	0	0	0	0	0	0	1	702	813	29	1		1	ANO7	2	242157737	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1199712	242157737	1041636	210	20730										
HDLBP	3069	broad.mit.edu	37	chr2	242176173	242176173	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attctcctggacaactggctCtgtactgtgaactagagaga	10	9	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:242176173C>G	uc002waz.2	-	21	2989	c.2761G>C	c.(2761-2763)GAG>CAG	p.E921Q	HDLBP_uc002wba.2_Missense_Mutation_p.E921Q|HDLBP_uc002wbb.2_Missense_Mutation_p.E873Q	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	921	KH 11.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		ACAACTGGCTCTGTACTGTGA	0.527													0	0	0	1	0	26	51										G	242176173	C	G	242176173	3	3	68	1	0	0	0	0	1	0	0	0	7025	922	32	1	1077	1	HDLBP	2	242176173	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	18436	242176173	1023200	211	20731										
C2orf85	285093	broad.mit.edu	37	chr2	242815144	242815144	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accatccccttcgcagtcttCgatgtcataaagcgcaaggg	9	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr2:242815144C>T	uc010fzu.1	+	2	1460	c.1437C>T	c.(1435-1437)TTC>TTT	p.F479F		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	479						integral to membrane				ovary(1)	1						TCGCAGTCTTCGATGTCATAA	0.632													0	0	0	1	0	15	73										T	242815144	C	T	242815144	2	4	68	1	0	0	0	0	0	0	0	1	2200	883	31	1		1	C2orf85	2	242815144	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	638971	242815144	384229	212	20732										
BHLHE40	8553	broad.mit.edu	37	chr3	5025300	5025300	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcccttctcccttgccagctCatccgtccgtcgactcttct	5	19	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:5025300C>T	uc003bqf.2	+	5	1469	c.1162C>T	c.(1162-1164)CAT>TAT	p.H388Y	BHLHE40_uc011asw.1_Missense_Mutation_p.H248Y	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	388						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTGCCAGCTCATCCGTCCGT	0.547													0	0	0	1	0	67	84										T	5025300	C	T	5025300	3	4	68	1	0	0	0	0	1	0	0	0	1423	826	29	1	1180	1	BHLHE40	3	5025300	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		5025300	192997130	213	20733										
RPL32	6161	broad.mit.edu	37	chr3	12877707	12877707	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggaaacattgtgagcgatCtcggcacagtaagatctgca	12	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:12877707C>T	uc003bxl.2	-	3	507	c.294G>A	c.(292-294)GAG>GAA	p.E98E	RPL32_uc003bxm.2_Silent_p.E98E|RPL32_uc003bxn.2_Silent_p.E98E	NM_001007074	NP_001007075	P62910	RL32_HUMAN	ribosomal protein L32	98					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			ovary(1)	1						TGTGAGCGATCTCGGCACAGT	0.522													0	0	0	1	0	37	45										T	12877707	C	T	12877707	2	4	68	1	0	0	0	0	0	0	0	1	13582	912	32	1		1	RPL32	3	12877707	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7852407	12877707	185144723	214	20734										
FBLN2	2199	broad.mit.edu	37	chr3	13670693	13670693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtgtgagacaggtgtgcacCgctgcggtgagggccaagtg	18	8	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:13670693C>T	uc011avb.1	+	12	2727	c.2602C>T	c.(2602-2604)CGC>TGC	p.R868C	FBLN2_uc011auz.1_Missense_Mutation_p.R894C|FBLN2_uc011ava.1_Missense_Mutation_p.R915C|FBLN2_uc011avc.1_Missense_Mutation_p.R915C	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	868	EGF-like 6; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGGTGTGCACCGCTGCGGTGA	0.652													0	0	0	1	0	12	46										T	13670693	C	T	13670693	3	4	68	1	0	0	0	0	1	0	0	0	5699	652	23	2	1479	2	FBLN2	3	13670693	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	792986	13670693	184351737	215	20735										
XPC	7508	broad.mit.edu	37	chr3	14190071	14190071	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccctcacgcacacgggatggGagtagccgccatggaaatca	12	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:14190071G>A	uc011ave.1	-	13	2515	c.2411C>T	c.(2410-2412)TCC>TTC	p.S804F	XPC_uc011avf.1_Missense_Mutation_p.S611F|XPC_uc011avg.1_Missense_Mutation_p.S767F	NM_004628	NP_004619	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	804	DNA-binding; preference for single stranded DNA; required for formation of stable nucleoprotein complex.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			ovary(2)|breast(1)	3						CACGGGATGGGAGTAGCCGCC	0.612			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				0	0	0	1	0	5	54										A	14190071	G	A	14190071	3	1	68	1	0	0	0	0	1	0	0	0	17438	1174	41	1	427	1	XPC	3	14190071	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	519378	14190071	183832359	216	20736										
EAF1	85403	broad.mit.edu	37	chr3	15477906	15477906	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagcagcagtgggagcagctCttcagactctgagagctctt	12	11	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:15477906C>G	uc003bzu.2	+	5	807	c.584C>G	c.(583-585)TCT>TGT	p.S195C	EAF1_uc011avq.1_Missense_Mutation_p.S94C	NM_033083	NP_149074	Q96JC9	EAF1_HUMAN	ELL associated factor 1	195	Ser-rich.|Necessary for transactivation activity.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cajal body|nuclear speck	protein binding			central_nervous_system(1)	1						GGGAGCAGCTCTTCAGACTCT	0.532													0	0	0	1	0	35	22										G	15477906	C	G	15477906	3	3	68	1	0	0	0	0	1	0	0	0	4875	913	32	1	602	1	EAF1	3	15477906	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1287835	15477906	182544524	217	20737										
EAF1	85403	broad.mit.edu	37	chr3	15477986	15477986	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acaatggcccagcctctcctCcgcagccttcacaccagcag	7	19	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:15477986C>T	uc003bzu.2	+	5	887	c.664C>T	c.(664-666)CCG>TCG	p.P222S	EAF1_uc011avq.1_Missense_Mutation_p.P121S	NM_033083	NP_149074	Q96JC9	EAF1_HUMAN	ELL associated factor 1	222	Necessary for transactivation activity.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cajal body|nuclear speck	protein binding			central_nervous_system(1)	1						AGCCTCTCCTCCGCAGCCTTC	0.587													0	0	0	1	0	68	39										T	15477986	C	T	15477986	3	4	68	1	0	0	0	0	1	0	0	0	4875	855	30	1	682	1	EAF1	3	15477986	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	80	15477986	182544444	218	20738										
NEK10	152110	broad.mit.edu	37	chr3	27233641	27233641	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaaggacaactgggatgtaGataagttgtctaaatatttc	9	6	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:27233641G>C	uc010hfk.2	-	5	549	c.320C>G	c.(319-321)TCT>TGT	p.S107C	NEK10_uc003cds.1_Missense_Mutation_p.S192C|NEK10_uc010hfj.2_Missense_Mutation_p.S107C			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	795							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						CTGGGATGTAGATAAGTTGTC	0.433													0	0	0	1	0	29	69										C	27233641	G	C	27233641	3	2	68	1	0	0	0	0	1	0	0	0	10322	957	33	1		1	NEK10	3	27233641	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11755655	27233641	170788789	219	20739										
UBP1	7342	broad.mit.edu	37	chr3	33467109	33467109	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaataagtaagcgtttcatCatgcagttttactgctggtg	9	7	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:33467109C>T	uc003cfq.3	-	2	768	c.238G>A	c.(238-240)GAT>AAT	p.D80N	UBP1_uc003cfr.3_Missense_Mutation_p.D80N|UBP1_uc010hga.2_Missense_Mutation_p.D80N	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	80					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						AGCGTTTCATCATGCAGTTTT	0.403													0	0	0	1	0	17	18										T	33467109	C	T	33467109	3	4	68	1	0	0	0	0	1	0	0	0	16892	826	29	1	1444	1	UBP1	3	33467109	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6233468	33467109	164555321	220	20740										
ITGA9	3680	broad.mit.edu	37	chr3	37574872	37574872	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccatcaacatcacagcgcctCagtgtcacgacggacagcag	9	15	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:37574872C>T	uc003chd.2	+	14	1494	c.1441C>T	c.(1441-1443)CAG>TAG	p.Q481*	ITGA9_uc003chc.2_Nonsense_Mutation_p.Q481*	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	481	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		CACAGCGCCTCAGTGTCACGA	0.557													0	0	0	1	0	9	34										T	37574872	C	T	37574872	4	4	68	1	0	0	0	0	0	1	0	0	7883	827	29	1	1495	1	ITGA9	3	37574872	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4107763	37574872	160447558	221	20741										
DLEC1	9940	broad.mit.edu	37	chr3	38139354	38139354	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcccagccacatggcgcatGaaggagagcccagtctccct	10	16	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:38139354G>A	uc003cho.1	+	18	2706	c.2685G>A	c.(2683-2685)ATG>ATA	p.M895I	DLEC1_uc003chp.1_Missense_Mutation_p.M895I|DLEC1_uc010hgv.1_Missense_Mutation_p.M895I|DLEC1_uc003chr.1_Missense_Mutation_p.M1I|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	895					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CATGGCGCATGAAGGAGAGCC	0.597													0	0	0	1	0	13	51										A	38139354	G	A	38139354	3	1	68	1	0	0	0	0	1	0	0	0	4552	1290	45	1	2755	1	DLEC1	3	38139354	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	564482	38139354	159883076	222	20742										
SLC22A14	9389	broad.mit.edu	37	chr3	38359724	38359724	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catgaagactaaggaaacatCatctgatgatgtctgaggaa	10	6	3	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:38359724C>G	uc010hhc.1	+	11	1811	c.1769C>G	c.(1768-1770)TCA>TGA	p.S590*	SLC22A14_uc003cib.2_Nonsense_Mutation_p.S590*|SLC22A14_uc011ayo.1_RNA	NM_004803	NP_004794	Q9Y267	S22AE_HUMAN	organic cation transporter like 4	590	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		AAGGAAACATCATCTGATGAT	0.488													0	0	0	1	0	21	109										G	38359724	C	G	38359724	4	3	68	1	0	0	0	0	0	1	0	0	14445	838	29	1	1807	1	SLC22A14	3	38359724	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	220370	38359724	159662706	223	20743										
EIF1B	10289	broad.mit.edu	37	chr3	40352532	40352532	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tatgacaaaaagaaacttgtGaaagctttcaaaaaggtaaa	7	4	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:40352532G>A	uc003ckc.2	+	2	440	c.180G>A	c.(178-180)GTG>GTA	p.V60V	uc003ckb.2_5'Flank	NM_005875	NP_005866	O60739	EIF1B_HUMAN	translation factor sui1 homolog	60					regulation of translational initiation		protein binding|translation initiation factor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)		AGAAACTTGTGAAAGCTTTCA	0.398													0	0	0	1	0	12	76										A	40352532	G	A	40352532	2	1	68	1	0	0	0	0	0	0	0	1	4994	1277	45	1		1	EIF1B	3	40352532	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1992808	40352532	157669898	224	20744										
LARS2	23395	broad.mit.edu	37	chr3	45441783	45441783	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttccatgttcccttatccttCtggtaagctgcacatgggcc	8	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:45441783C>G	uc003cop.1	+	4	466	c.281C>G	c.(280-282)TCT>TGT	p.S94C	LARS2_uc010hit.1_Intron	NM_015340	NP_056155	Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	94	HIGH region.				leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	CCTTATCCTTCTGGTAAGCTG	0.463													0	0	0	1	0	34	79										G	45441783	C	G	45441783	3	3	68	1	0	0	0	0	1	0	0	0	8635	913	32	1	287	1	LARS2	3	45441783	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5089251	45441783	152580647	225	20745										
LZTFL1	54585	broad.mit.edu	37	chr3	45872601	45872601	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcaaccttgacttcaatttCtcattctcttcttgaagtct	3	11	6	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:45872601C>G	uc003cox.1	-	6	624	c.486G>C	c.(484-486)GAG>GAC	p.E162D	LZTFL1_uc003coy.1_Missense_Mutation_p.E145D|LZTFL1_uc011bak.1_RNA	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	162	Potential.										0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		ACTTCAATTTCTCATTCTCTT	0.224													0	0	0	1	0	6	31										G	45872601	C	G	45872601	3	3	68	1	0	0	0	0	1	0	0	0	9136	912	32	1	433	1	LZTFL1	3	45872601	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	430818	45872601	152149829	226	20746										
SCAP	22937	broad.mit.edu	37	chr3	47459204	47459204	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccccgggggcggtgtctcaGgggagggctgtccccaggct	19	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:47459204G>C	uc003crh.1	-	17	2815	c.2560C>G	c.(2560-2562)CTG>GTG	p.L854V	SCAP_uc011baz.1_Missense_Mutation_p.L598V|SCAP_uc003crg.2_Missense_Mutation_p.L461V	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	854	Interaction with SREBF2 (By similarity).|Cytoplasmic (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		CGGTGTCTCAGGGGAGGGCTG	0.657													0	0	0	1	0	5	15										C	47459204	G	C	47459204	3	2	68	1	0	0	0	0	1	0	0	0	13877	991	35	4	1307	4	SCAP	3	47459204	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1586603	47459204	150563226	227	20747										
P4HTM	54681	broad.mit.edu	37	chr3	49040020	49040020	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgcgatcaaggctgaccctGatggtgacggtgagctcaca	13	12	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:49040020G>T	uc003cvg.2	+	4	1064	c.715G>T	c.(715-717)GAT>TAT	p.D239Y	P4HTM_uc003cvh.2_Missense_Mutation_p.D239Y|P4HTM_uc010hkm.1_Missense_Mutation_p.D125Y	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	239	Lumenal (Potential).|EF-hand 2.|2 (Potential).					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	GGCTGACCCTGATGGTGACGG	0.562													1	0	2.27111e-07	1	2.43748e-07	13	72										T	49040020	G	T	49040020	3	4	68	1	0	0	0	0	1	0	0	0	11360	1290	45	3	729	3	P4HTM	3	49040020	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1580816	49040020	148982410	228	20748										
DALRD3	55152	broad.mit.edu	37	chr3	49054900	49054900	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtcctcgggccaatgccaTagagcctcttgcagctcagc	10	15	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:49054900T>C	uc003cvk.1	-	4	785	c.765A>G	c.(763-765)CTA>CTG	p.L255L	DALRD3_uc003cvl.1_Silent_p.L255L|DALRD3_uc003cvm.1_Silent_p.L88L|DALRD3_uc010hko.1_Silent_p.L88L|DALRD3_uc011bca.1_Silent_p.L255L	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	255					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCAATGCCATAGAGCCTCTT	0.527													0	0	0	1	0	16	26										C	49054900	T	C	49054900	2	2	68	1	0	0	0	0	0	0	0	1	4229	1393	49	5		5	DALRD3	3	49054900	Silent	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	14880	49054900	148967530	229	20749										
QRICH1	54870	broad.mit.edu	37	chr3	49094851	49094851	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggtggccaccggctgccctGagatggcgtaggacacagtg	16	12	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:49094851G>A	uc010hkq.2	-	4	1078	c.782C>T	c.(781-783)TCA>TTA	p.S261L	QRICH1_uc003cvu.2_Missense_Mutation_p.S261L|QRICH1_uc003cvv.2_Missense_Mutation_p.S261L	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	261	Gln-rich.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CGGCTGCCCTGAGATGGCGTA	0.612													0	0	0	1	0	11	57										A	49094851	G	A	49094851	3	1	68	1	0	0	0	0	1	0	0	0	12879	1294	45	1	1580	1	QRICH1	3	49094851	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	39951	49094851	148927579	230	20750										
C3orf62	375341	broad.mit.edu	37	chr3	49314142	49314142	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtgcacgggcagcgagaagGagagcggcgcggcgctcagt	19	10	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:49314142G>A	uc003cwn.2	-	1	367	c.164C>T	c.(163-165)TCC>TTC	p.S55F	C3orf62_uc003cwm.2_5'Flank	NM_198562	NP_940964	Q6ZUJ4	CC062_HUMAN	hypothetical protein LOC375341	55											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGCGAGAAGGAGAGCGGCGC	0.587													0	0	0	1	0	13	54										A	49314142	G	A	49314142	3	1	68	1	0	0	0	0	1	0	0	0	2238	1174	41	1	651	1	C3orf62	3	49314142	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	219291	49314142	148708288	231	20751										
GMPPB	29925	broad.mit.edu	37	chr3	49759286	49759286	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcattaactatgacgtcctCacccagcactgtcacgttct	5	14	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:49759286C>T	uc003cxk.1	-	9	1207	c.982G>A	c.(982-984)GAG>AAG	p.E328K	AMIGO3_uc003cxj.2_5'Flank|GMPPB_uc003cxl.1_Missense_Mutation_p.E355K	NM_021971	NP_068806	Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B isoform 2	328					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATGACGTCCTCACCCAGCACT	0.597													0	0	0	1	0	14	40										T	49759286	C	T	49759286	3	4	68	1	0	0	0	0	1	0	0	0	6495	835	29	1	104	1	GMPPB	3	49759286	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	445144	49759286	148263144	232	20752										
C3orf18	51161	broad.mit.edu	37	chr3	50603073	50603073	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcaggttccaggtcagactCagaggtgggtgggcggctgc	19	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:50603073C>G	uc003das.2	-	2	509	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	C3orf18_uc003dar.2_Missense_Mutation_p.E20Q|C3orf18_uc011bdr.1_Intron|C3orf18_uc010hlo.2_Missense_Mutation_p.E20Q|C3orf18_uc010hlp.2_Intron|C3orf18_uc003dat.2_Missense_Mutation_p.E20Q	NM_016210	NP_057294	Q9UK00	CC018_HUMAN	hypothetical protein LOC51161	20						integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.0175)|Kidney(197;0.0207)		AGGTCAGACTCAGAGGTGGGT	0.622													0	0	0	1	0	3	23										G	50603073	C	G	50603073	3	3	68	1	0	0	0	0	1	0	0	0	2211	835	29	1	446	1	C3orf18	3	50603073	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	843787	50603073	147419357	233	20753										
DUSP7	1849	broad.mit.edu	37	chr3	52090218	52090218	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctgcagccactcggcgctCttgcagggcatggcccctgc	12	17	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:52090218C>A	uc003dct.2	-	1	244	c.165G>T	c.(163-165)AAG>AAT	p.K55N	DUSP7_uc010hma.2_Missense_Mutation_p.K55N	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	55					inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ACTCGGCGCTCTTGCAGGGCA	0.398													1	0	0.115264	1	0.115908	3	7										A	52090218	C	A	52090218	3	1	68	1	0	0	0	0	1	0	0	0	4830	912	32	3	1106	3	DUSP7	3	52090218	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1487145	52090218	145932212	234	20754										
POC1A	25886	broad.mit.edu	37	chr3	52183865	52183865	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agatgcggacagtcttgtctCgggagccggaagcaagcagg	16	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:52183865C>T	uc003dcu.2	-	3	560	c.242G>A	c.(241-243)CGA>CAA	p.R81Q	POC1A_uc003dcv.2_Missense_Mutation_p.R43Q|POC1A_uc003dcw.2_Missense_Mutation_p.R81Q	NM_015426	NP_056241	Q8NBT0	POC1A_HUMAN	WD repeat domain 51A isoform 1	81	WD 2.					centriole|microtubule basal body					0						AGTCTTGTCTCGGGAGCCGGA	0.597													0	0	0	1	0	11	51										T	52183865	C	T	52183865	3	4	68	1	0	0	0	0	1	0	0	0	12175	884	31	1	1017	1	POC1A	3	52183865	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	93647	52183865	145838565	235	20755										
PTPRG	5793	broad.mit.edu	37	chr3	62188855	62188855	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaccctttccagcccacagcGtctcctgcctcttcagccga	7	19	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:62188855G>A	uc003dlb.2	+	12	2105	c.1386G>A	c.(1384-1386)GCG>GCA	p.A462A	PTPRG_uc003dlc.2_Silent_p.A462A	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	462	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		AGCCCACAGCGTCTCCTGCCT	0.547													0	0	0	1	0	13	65										A	62188855	G	A	62188855	2	1	68	1	0	0	0	0	0	0	0	1	12802	1132	40	2		2	PTPRG	3	62188855	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10004990	62188855	135833575	236	20756										
CADPS	8618	broad.mit.edu	37	chr3	62385241	62385241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtccaggaccccttgcaatCggaaatctctgtaggttttc	9	11	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:62385241C>T	uc003dll.2	-	30	4262	c.3902G>A	c.(3901-3903)CGA>CAA	p.R1301Q	CADPS_uc003dlj.1_Missense_Mutation_p.R256Q|CADPS_uc003dlk.1_Missense_Mutation_p.R749Q|CADPS_uc003dlm.2_Missense_Mutation_p.R1262Q|CADPS_uc003dln.2_Missense_Mutation_p.R1222Q	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1301	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CCCTTGCAATCGGAAATCTCT	0.488													0	0	0	1	0	19	67										T	62385241	C	T	62385241	3	4	68	1	0	0	0	0	1	0	0	0	2570	884	31	1	163	1	CADPS	3	62385241	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	196386	62385241	135637189	237	20757										
PDZRN3	23024	broad.mit.edu	37	chr3	73453372	73453372	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtgagggccatgatatgttCaaaggtgatgtcggtttggg	16	4	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:73453372C>T	uc003dpl.1	-	4	1189	c.1093G>A	c.(1093-1095)GAA>AAA	p.E365K	PDZRN3_uc011bgh.1_Missense_Mutation_p.E22K|PDZRN3_uc010hoe.1_Missense_Mutation_p.E63K|PDZRN3_uc011bgf.1_Missense_Mutation_p.E82K|PDZRN3_uc011bgg.1_Missense_Mutation_p.E85K	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	365							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		ATGATATGTTCAAAGGTGATG	0.512													0	0	0	1	0	49	65										T	73453372	C	T	73453372	3	4	68	1	0	0	0	0	1	0	0	0	11709	835	29	1	2135	1	PDZRN3	3	73453372	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	11068131	73453372	124569058	238	20758										
CNTN3	5067	broad.mit.edu	37	chr3	74351884	74351884	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatgaaacactgtccaccccCgtttgcaccatacaaacata	5	14	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:74351884C>T	uc003dpm.1	-	13	1823	c.1743G>A	c.(1741-1743)ACG>ACA	p.T581T		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	581	Ig-like C2-type 6.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TGTCCACCCCCGTTTGCACCA	0.408													0	0	0	1	0	5	23										T	74351884	C	T	74351884	2	4	68	1	0	0	0	0	0	0	0	1	3642	639	23	2		2	CNTN3	3	74351884	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	898512	74351884	123670546	239	20759										
TFG	10342	broad.mit.edu	37	chr3	100432575	100432575	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggaagctaatcatcaaagctCaacttggggaggatattcgg	12	7	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:100432575C>T	uc003due.2	+	2	495	c.46C>T	c.(46-48)CAA>TAA	p.Q16*	TFG_uc003duf.2_Nonsense_Mutation_p.Q16*|TFG_uc003dug.2_Nonsense_Mutation_p.Q16*|TFG_uc003duh.2_Nonsense_Mutation_p.Q16*|TFG_uc003dui.2_Nonsense_Mutation_p.Q16*	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	16					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						CATCAAAGCTCAACTTGGGGA	0.378			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	1	0	38	79										T	100432575	C	T	100432575	4	4	68	1	0	0	0	0	0	1	0	0	15803	827	29	1	48	1	TFG	3	100432575	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	26080691	100432575	97589855	240	20760										
TFG	10342	broad.mit.edu	37	chr3	100432661	100432661	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctaatgatgcaacgagttttCagaggaaaacttctgagtaa	9	6	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:100432661C>T	uc003due.2	+	2	581	c.132C>T	c.(130-132)TTC>TTT	p.F44F	TFG_uc003duf.2_Silent_p.F44F|TFG_uc003dug.2_Silent_p.F44F|TFG_uc003duh.2_Silent_p.F44F|TFG_uc003dui.2_Silent_p.F44F	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	44					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						AACGAGTTTTCAGAGGAAAAC	0.289			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	1	0	32	56										T	100432661	C	T	100432661	2	4	68	1	0	0	0	0	0	0	0	1	15803	825	29	1		1	TFG	3	100432661	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	86	100432661	97589769	241	20761										
CEP97	79598	broad.mit.edu	37	chr3	101451356	101451356	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttttttggcatccttaactGaattggaacagttgtcgatt	8	7	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:101451356G>A	uc003dvk.1	+	6	613	c.586G>A	c.(586-588)GAA>AAA	p.E196K	CEP97_uc010hpm.1_Missense_Mutation_p.E162K|CEP97_uc011bhf.1_Missense_Mutation_p.E196K|CEP97_uc003dvl.1_5'UTR|CEP97_uc003dvm.1_Missense_Mutation_p.E34K	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	196	LRR 8.					centrosome|nucleus	protein binding			ovary(2)	2						ATCCTTAACTGAATTGGAACA	0.398													0	0	0	1	0	8	52										A	101451356	G	A	101451356	3	1	68	1	0	0	0	0	1	0	0	0	3263	1291	45	1	608	1	CEP97	3	101451356	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1018695	101451356	96571074	242	20762										
FAM55C	91775	broad.mit.edu	37	chr3	101540511	101540511	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcggctcaggaacatccgtCgagcagtggttcggctcctc	14	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:101540511C>T	uc003dvn.2	+	8	2030	c.1393C>T	c.(1393-1395)CGA>TGA	p.R465*	FAM55C_uc010hpn.2_Nonsense_Mutation_p.R465*	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	465						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						GAACATCCGTCGAGCAGTGGT	0.572													0	0	0	1	0	18	92										T	101540511	C	T	101540511	4	4	68	1	0	0	0	0	0	1	0	0	5586	876	31	1	1411	1	FAM55C	3	101540511	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	89155	101540511	96481919	243	20763										
FAM55C	91775	broad.mit.edu	37	chr3	101540531	101540531	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgagcagtggttcggctcctCgatcgaagcccaaagaccgt	12	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:101540531C>T	uc003dvn.2	+	8	2050	c.1413C>T	c.(1411-1413)CTC>CTT	p.L471L	FAM55C_uc010hpn.2_Silent_p.L471L	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	471						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						TTCGGCTCCTCGATCGAAGCC	0.572													0	0	0	1	0	18	110										T	101540531	C	T	101540531	2	4	68	1	0	0	0	0	0	0	0	1	5586	871	31	1		1	FAM55C	3	101540531	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	20	101540531	96481899	244	20764										
SLC35A5	55032	broad.mit.edu	37	chr3	112300027	112300027	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctggtctttgacttcaggCcctccctggaatttttcttg	8	12	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:112300027C>G	uc003dze.2	+	6	1308	c.1063C>G	c.(1063-1065)CCC>GCC	p.P355A		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	355	Helical; (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						TGACTTCAGGCCCTCCCTGGA	0.448													0	0	0	1	0	13	72										G	112300027	C	G	112300027	3	3	68	1	0	0	0	0	1	0	0	0	14574	739	26	4	1081	4	SLC35A5	3	112300027	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10759496	112300027	85722403	245	20765										
BOC	91653	broad.mit.edu	37	chr3	113002302	113002302	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcgactgccacccccaactCtggccccaccacagccgccc	7	23	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:113002302C>G	uc003dzx.2	+	16	3097	c.2476C>G	c.(2476-2478)CTG>GTG	p.L826V	BOC_uc003dzy.2_Missense_Mutation_p.L826V|BOC_uc003dzz.2_Missense_Mutation_p.L827V|BOC_uc003eab.2_Missense_Mutation_p.L527V|BOC_uc003eac.2_Missense_Mutation_p.L141V	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	826	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			ACCCCCAACTCTGGCCCCACC	0.572													0	0	0	1	0	30	143										G	113002302	C	G	113002302	3	3	68	1	0	0	0	0	1	0	0	0	1481	912	32	1	2530	1	BOC	3	113002302	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	702275	113002302	85020128	246	20766										
KIAA2018	205717	broad.mit.edu	37	chr3	113379239	113379239	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcaaagtagtccacgttgtCtgtgtgtttccagctgaaga	11	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:113379239C>G	uc003eam.2	-	7	1701	c.1290G>C	c.(1288-1290)CAG>CAC	p.Q430H	KIAA2018_uc003eal.2_Missense_Mutation_p.Q374H	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	430					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TCCACGTTGTCTGTGTGTTTC	0.413													0	0	0	1	0	16	79										G	113379239	C	G	113379239	3	3	68	1	0	0	0	0	1	0	0	0	8268	912	32	1	5451	1	KIAA2018	3	113379239	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	376937	113379239	84643191	247	20767										
ZBTB20	26137	broad.mit.edu	37	chr3	114069835	114069835	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggctcactctcggtgccctCggcctggtctgtgtcttccg	13	15	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:114069835C>T	uc003ebi.2	-	4	1270	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	ZBTB20_uc003ebj.2_Missense_Mutation_p.E291K|ZBTB20_uc010hqp.2_Missense_Mutation_p.E291K|ZBTB20_uc003ebk.2_Missense_Mutation_p.E291K|ZBTB20_uc003ebl.2_Missense_Mutation_p.E291K|ZBTB20_uc003ebm.2_Missense_Mutation_p.E291K|ZBTB20_uc003ebn.2_Missense_Mutation_p.E291K|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TCGGTGCCCTCGGCCTGGTCT	0.607													0	0	0	1	0	16	52										T	114069835	C	T	114069835	3	4	68	1	0	0	0	0	1	0	0	0	17526	893	31	1	1143	1	ZBTB20	3	114069835	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	690596	114069835	83952595	248	20768										
MYLK	4638	broad.mit.edu	37	chr3	123419600	123419600	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccgatagggtctttgtactCaccttcttccccaggaggtc	9	13	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:123419600C>T	uc003ego.2	-	18	2997	c.2715G>A	c.(2713-2715)GTG>GTA	p.V905V	MYLK_uc011bjw.1_Silent_p.V905V|MYLK_uc003egp.2_Silent_p.V836V|MYLK_uc003egq.2_Silent_p.V905V|MYLK_uc003egr.2_Silent_p.V836V|MYLK_uc003egs.2_Silent_p.V729V|MYLK_uc003egt.2_Silent_p.V96V	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	905	1-2.|5 X 28 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCTTTGTACTCACCTTCTTCC	0.592													0	0	0	1	0	8	55										T	123419600	C	T	123419600	2	4	68	1	0	0	0	0	0	0	0	1	10056	813	29	1		1	MYLK	3	123419600	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9349765	123419600	74602830	249	20769										
CCDC14	64770	broad.mit.edu	37	chr3	123634090	123634090	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctgctcttatttgtggctGaggggatagtctcttagaaa	12	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:123634090G>A	uc011bjx.1	-	13	2489	c.2398C>T	c.(2398-2400)CAG>TAG	p.Q800*	CCDC14_uc003egv.3_Nonsense_Mutation_p.Q441*|CCDC14_uc003egx.3_Nonsense_Mutation_p.Q600*|CCDC14_uc010hrt.2_Nonsense_Mutation_p.Q759*|CCDC14_uc003egy.3_Nonsense_Mutation_p.Q600*|CCDC14_uc003egz.2_Intron	NM_022757	NP_073594	Q49A88	CCD14_HUMAN	coiled-coil domain containing 14	800						centrosome					0		Lung NSC(201;0.0371)|Prostate(884;0.0405)|Myeloproliferative disorder(1037;0.205)		Lung(219;0.00942)|GBM - Glioblastoma multiforme(114;0.159)		ATTTGTGGCTGAGGGGATAGT	0.388													0	0	0	1	0	17	74										A	123634090	G	A	123634090	4	1	68	1	0	0	0	0	0	1	0	0	2773	1299	45	1	467	1	CCDC14	3	123634090	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	214490	123634090	74388340	250	20770										
EEFSEC	60678	broad.mit.edu	37	chr3	127872571	127872571	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgcccgagttccaggcagCgcccgaggccgagcccgagc	14	16	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:127872571C>T	uc003eki.2	+	1	259	c.221C>T	c.(220-222)GCG>GTG	p.A74V	EEFSEC_uc003ekj.2_Missense_Mutation_p.A74V|RUVBL1_uc003ekf.2_5'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	74						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						TTCCAGGCAGCGCCCGAGGCC	0.716													0	0	0	1	0	2	2										T	127872571	C	T	127872571	3	4	68	1	0	0	0	0	1	0	0	0	4931	768	27	2	223	2	EEFSEC	3	127872571	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4238481	127872571	70149859	251	20771										
ACAD9	28976	broad.mit.edu	37	chr3	128631370	128631370	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgctccagaaaacctagatGagcagattaagaaagtgtcc	9	8	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:128631370G>A	uc003ela.3	+	18	1988	c.1786G>A	c.(1786-1788)GAG>AAG	p.E596K	KIAA1257_uc003elg.1_Intron|ACAD9_uc011bks.1_Missense_Mutation_p.E473K|ACAD9_uc003elb.2_Missense_Mutation_p.E473K|ACAD9_uc003eld.1_RNA|ACAD9_uc003ele.2_Missense_Mutation_p.E248K|uc003elf.1_Intron	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	596						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3						AAACCTAGATGAGCAGATTAA	0.512													0	0	0	1	0	21	28										A	128631370	G	A	128631370	3	1	68	1	0	0	0	0	1	0	0	0	111	1291	45	1	1856	1	ACAD9	3	128631370	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	758799	128631370	69391060	252	20772										
C3orf37	56941	broad.mit.edu	37	chr3	129007759	129007759	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcttggtcccttcttggttCaaagaaagtgatccttccaa	9	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:129007759C>T	uc003elt.2	+	3	334	c.246C>T	c.(244-246)TTC>TTT	p.F82F	C3orf37_uc003elu.2_Silent_p.F82F|C3orf37_uc003elv.2_Silent_p.F82F|C3orf37_uc003elw.2_Silent_p.F82F	NM_020187	NP_064572	Q96FZ2	CC037_HUMAN	hypothetical protein LOC56941	82										ovary(1)	1						CTTCTTGGTTCAAAGAAAGTG	0.478													0	0	0	1	0	9	69										T	129007759	C	T	129007759	2	4	68	1	0	0	0	0	0	0	0	1	2227	825	29	1		1	C3orf37	3	129007759	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	376389	129007759	69014671	253	20773										
H1FX	8971	broad.mit.edu	37	chr3	129034497	129034497	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgaggtaggtgcgcccattCtgctggtcgaaccacggaac	13	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:129034497C>G	uc003elx.2	-	1	624	c.249G>C	c.(247-249)CAG>CAC	p.Q83H	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	83	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding				0						TGCGCCCATTCTGCTGGTCGA	0.612													0	0	0	1	0	3	3										G	129034497	C	G	129034497	3	3	68	1	0	0	0	0	1	0	0	0	6923	912	32	1	396	1	H1FX	3	129034497	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	26738	129034497	68987933	254	20774										
COL6A6	131873	broad.mit.edu	37	chr3	130287183	130287183	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctttgtgtctcagtacttCagccccaccaagggcgcccg	10	15	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:130287183C>T	uc010htl.2	+	5	2167	c.2136C>T	c.(2134-2136)TTC>TTT	p.F712F		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	712	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CTCAGTACTTCAGCCCCACCA	0.502													0	0	0	1	0	21	93										T	130287183	C	T	130287183	2	4	68	1	0	0	0	0	0	0	0	1	3703	825	29	1		1	COL6A6	3	130287183	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1252686	130287183	67735247	255	20775										
NEK11	79858	broad.mit.edu	37	chr3	130799266	130799266	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taaaattttttttgatctcaGaaaggtacttaaggaaatat	6	3	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:130799266G>C	uc003eny.2	+	4	497	c.171_splice	c.e4-1	p.L57_splice	NEK11_uc003enx.2_Splice_Site_p.L57_splice|NEK11_uc003eoa.2_Splice_Site_p.L57_splice|NEK11_uc003enz.2_Splice_Site|NEK11_uc010htn.2_Splice_Site|NEK11_uc011blk.1_Intron|NEK11_uc011bll.1_Splice_Site_p.L57_splice|NEK11_uc003enw.1_Splice_Site_p.L57_splice|NEK11_uc011blm.1_Splice_Site_p.L57_splice|NEK11_uc010hto.1_5'Flank	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1						cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						TTTGATCTCAGAAAGGTACTT	0.378													0	0	0	1	0	3	18										C	130799266	G	C	130799266	5	2	68	1	0	0	0	0	0	0	1	0	10323	956	33	1	176	1	NEK11	3	130799266	Splice_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	512083	130799266	67223164	256	20776										
TMEM22	80723	broad.mit.edu	37	chr3	136574418	136574418	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgcacatatttcctagcatCtatgatgtttttggaggggt	10	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:136574418C>G	uc003erf.3	+	2	1330	c.1116C>G	c.(1114-1116)ATC>ATG	p.I372M	TMEM22_uc003erg.3_Missense_Mutation_p.I372M|TMEM22_uc010hub.2_Missense_Mutation_p.I372M	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	372	DUF6 2.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						TTCCTAGCATCTATGATGTTT	0.403													0	0	0	1	0	33	157										G	136574418	C	G	136574418	3	3	68	1	0	0	0	0	1	0	0	0	16140	903	32	1	1118	1	TMEM22	3	136574418	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5775152	136574418	61448012	257	20777										
MED12L	116931	broad.mit.edu	37	chr3	150883739	150883739	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acactttatcataagattttCtgggcaaaccaaaacaaaga	5	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:150883739C>G	uc003eyp.2	+	10	1502	c.1464C>G	c.(1462-1464)TTC>TTG	p.F488L	MED12L_uc011bnz.1_Missense_Mutation_p.F348L|MED12L_uc003eyn.2_Missense_Mutation_p.F488L|MED12L_uc003eyo.2_Missense_Mutation_p.F488L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	488					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATAAGATTTTCTGGGCAAACC	0.343													0	0	0	1	0	25	98										G	150883739	C	G	150883739	3	3	68	1	0	0	0	0	1	0	0	0	9429	912	32	1	1502	1	MED12L	3	150883739	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	14309321	150883739	47138691	258	20778										
OTOL1	131149	broad.mit.edu	37	chr3	161221331	161221331	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agagtgccccggtcggctttCagcgctggtttgtcaaagcc	13	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:161221331C>T	uc011bpb.1	+	4	1035	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	345	C1q.					collagen					0						GGTCGGCTTTCAGCGCTGGTT	0.517													0	0	0	1	0	13	41										T	161221331	C	T	161221331	2	4	68	1	0	0	0	0	0	0	0	1	11304	825	29	1		1	OTOL1	3	161221331	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10337592	161221331	36801099	259	20779										
OTOL1	131149	broad.mit.edu	37	chr3	161221535	161221535	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccagaataagaagcagttCaagtccagagaaactctcta	8	10	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:161221535C>G	uc011bpb.1	+	4	1239	c.1239C>G	c.(1237-1239)TTC>TTG	p.F413L		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	413	C1q.					collagen					0						AGAAGCAGTTCAAGTCCAGAG	0.473													0	0	0	1	0	5	42										G	161221535	C	G	161221535	3	3	68	1	0	0	0	0	1	0	0	0	11304	825	29	1	1253	1	OTOL1	3	161221535	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	204	161221535	36800895	260	20780										
LRRIQ4	344657	broad.mit.edu	37	chr3	169539961	169539961	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggataagaacaacctgagGagcctgtgcccggcgctggg	15	11	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:169539961G>T	uc003fgb.2	+	1	252	c.252G>T	c.(250-252)AGG>AGT	p.R84S		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	84	LRR 3.										0						ACAACCTGAGGAGCCTGTGCC	0.532													1	0	6.72482e-11	1	7.47862e-11	15	124										T	169539961	G	T	169539961	3	4	68	1	0	0	0	0	1	0	0	0	9031	1165	41	3	254	3	LRRIQ4	3	169539961	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8318426	169539961	28482469	261	20781										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	12	81										A	178936091	G	A	178936091	3	1	68	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9396130	178936091	19086339	262	20782										
YEATS2	55689	broad.mit.edu	37	chr3	183503990	183503990	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgccagccacctcacagctCtcgaagcctggaaccacaat	8	16	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:183503990C>T	uc003fly.2	+	20	3009	c.2814C>T	c.(2812-2814)CTC>CTT	p.L938L	YEATS2_uc003flz.2_Silent_p.L17L	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	938					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCTCACAGCTCTCGAAGCCTG	0.547													0	0	0	1	0	30	54										T	183503990	C	T	183503990	2	4	68	1	0	0	0	0	0	0	0	1	17469	900	32	1		1	YEATS2	3	183503990	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4567899	183503990	14518440	263	20783										
DVL3	1857	broad.mit.edu	37	chr3	183883967	183883967	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccaaagcaacgagcgtggtGacggcggcatctacattggc	14	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:183883967G>T	uc003fms.2	+	8	957	c.817G>T	c.(817-819)GAC>TAC	p.D273Y	DVL3_uc011bqw.1_Missense_Mutation_p.D273Y|DVL3_uc003fmt.2_5'UTR|DVL3_uc003fmu.2_Missense_Mutation_p.D105Y	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	273	PDZ.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			CGAGCGTGGTGACGGCGGCAT	0.502													1	0	9.31168e-06	1	9.77726e-06	12	109										T	183883967	G	T	183883967	3	4	68	1	0	0	0	0	1	0	0	0	4837	1290	45	3	847	3	DVL3	3	183883967	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	379977	183883967	14138463	264	20784										
FAM131A	131408	broad.mit.edu	37	chr3	184059850	184059850	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctccaccctcccctatctCcaggtatttcccaggtggtg	7	16	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:184059850C>T	uc003fog.2	+	1	1593	c.229C>T	c.(229-231)CCA>TCA	p.P77S	FAM131A_uc003fob.1_Intron|FAM131A_uc003foc.2_Intron|FAM131A_uc003foe.2_Intron	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	77						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCCCCTATCTCCAGGTATTTC	0.597													0	0	0	1	0	75	177										T	184059850	C	T	184059850	3	4	68	1	0	0	0	0	1	0	0	0	5439	870	30	1		1	FAM131A	3	184059850	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	175883	184059850	13962580	265	20785										
MASP1	5648	broad.mit.edu	37	chr3	186947621	186947621	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atccagggagtggtgcctttCtgggctgggcgtccattgaa	15	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:186947621C>G	uc003frh.1	-	11	1700	c.1368G>C	c.(1366-1368)CAG>CAC	p.Q456H		NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	456	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TGGTGCCTTTCTGGGCTGGGC	0.597													0	0	0	1	0	11	38										G	186947621	C	G	186947621	3	3	68	1	0	0	0	0	1	0	0	0	9322	912	32	1	755	1	MASP1	3	186947621	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2887771	186947621	11074809	266	20786										
ATP13A5	344905	broad.mit.edu	37	chr3	193031929	193031929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aatgatcacttggctgcctgGagggatcatttcagaattct	10	8	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:193031929G>A	uc011bsq.1	-	19	2212	c.2212C>T	c.(2212-2214)CCA>TCA	p.P738S		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	738					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TGGCTGCCTGGAGGGATCATT	0.478													0	0	0	1	0	55	107										A	193031929	G	A	193031929	3	1	68	1	0	0	0	0	1	0	0	0	1127	1174	41	1	1490	1	ATP13A5	3	193031929	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6084308	193031929	4990501	267	20787										
MUC4	4585	broad.mit.edu	37	chr3	195516055	195516055	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaggggtagctgtgcccgctGaggtggttcgtgaccctgag	17	9	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:195516055G>T	uc011bto.1	-	2	2856	c.2396C>A	c.(2395-2397)TCA>TAA	p.S799*	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Nonsense_Mutation_p.S681*	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	804	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTGCCCGCTGAGGTGGTTCG	0.587													1	0	2.32078e-09	1	2.5472e-09	12	123										T	195516055	G	T	195516055	4	4	68	1	0	0	0	0	0	1	0	0	9978	1294	45	3		3	MUC4	3	195516055	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2484126	195516055	2506375	268	20788										
MUC4	4585	broad.mit.edu	37	chr3	195517505	195517505	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agaaaaagctgttgtgtcctGagtagaagtccttgagaaag	12	5	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr3:195517505G>C	uc011bto.1	-	2	1406	c.946C>G	c.(946-948)CAG>GAG	p.Q316E	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.Q198E	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	321					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTTGTGTCCTGAGTAGAAGTC	0.468													0	0	0	1	0	31	135										C	195517505	G	C	195517505	3	2	68	1	0	0	0	0	1	0	0	0	9978	1299	45	1		1	MUC4	3	195517505	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1450	195517505	2504925	269	20789										
RNF4	6047	broad.mit.edu	37	chr4	2514856	2514856	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctgcatggacggatactcaGaggtaagtaaaccaagctgt	11	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:2514856G>A	uc003gfb.2	+	7	757	c.421G>A	c.(421-423)GAG>AAG	p.E141K	RNF4_uc010icj.2_Silent_p.Q87Q|RNF4_uc003gfc.2_Missense_Mutation_p.E141K	NM_002938	NP_002929	P78317	RNF4_HUMAN	ring finger protein 4	141	RING-type.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination|regulation of kinetochore assembly|regulation of spindle assembly|response to arsenic-containing substance	cytoplasm|PML body	androgen receptor binding|DNA binding|nucleosome binding|sequence-specific DNA binding transcription factor activity|SUMO polymer binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(65;0.241)				CGGATACTCAGAGGTAAGTAA	0.458													0	0	0	1	0	13	230										A	2514856	G	A	2514856	3	1	68	1	0	0	0	0	1	0	0	0	13492	943	33	1	443	1	RNF4	4	2514856	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		2514856	188639420	270	20790										
DOK7	285489	broad.mit.edu	37	chr4	3465126	3465126	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accgaggcggcgctggtggaGggccaggtcaagctgcggga	20	10	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:3465126G>A	uc003ghd.2	+	1	94	c.24G>A	c.(22-24)GAG>GAA	p.E8E	DOK7_uc003ghe.2_5'UTR	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	8	PH.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CGCTGGTGGAGGGCCAGGTCA	0.378													0	0	0	1	0	2	3										A	3465126	G	A	3465126	2	1	68	1	0	0	0	0	0	0	0	1	4702	991	35	2		2	DOK7	4	3465126	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	950270	3465126	187689150	271	20791										
ADRA2C	152	broad.mit.edu	37	chr4	3768990	3768990	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctcctgcatcggctccttCttcgcgccctgcctcatcat	6	19	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:3768990C>T	uc003ghm.2	+	1	695	c.657C>T	c.(655-657)TTC>TTT	p.F219F	ADRA2C_uc010icx.2_Silent_p.F219F	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	219	Helical; Name=5; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TCGGCTCCTTCTTCGCGCCCT	0.697													0	0	0	1	0	5	5										T	3768990	C	T	3768990	2	4	68	1	0	0	0	0	0	0	0	1	339	912	32	1		1	ADRA2C	4	3768990	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	303864	3768990	187385286	272	20792										
SORCS2	57537	broad.mit.edu	37	chr4	7194756	7194756	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccgctggccggagtggcttCgcgggcgcaggtctcgctca	17	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:7194756C>A	uc003gkb.3	+	1	383	c.383C>A	c.(382-384)TCG>TAG	p.S128*		NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	128	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						GGAGTGGCTTCGCGGGCGCAG	0.741													1	0	6.4e-05	1	6.66446e-05	3	7										A	7194756	C	A	7194756	4	1	68	1	0	0	0	0	0	1	0	0	14931	893	31	3	385	3	SORCS2	4	7194756	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3425766	7194756	183959520	273	20793										
GPR78	27201	broad.mit.edu	37	chr4	8583003	8583003	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacgcggcgctgagcgtggcGgcgctgagcgcagaccagtg	18	12	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:8583003G>A	uc003glk.2	+	1	713	c.294G>A	c.(292-294)GCG>GCA	p.A98A	CPZ_uc003gll.2_RNA	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	98	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						TGAGCGTGGCGGCGCTGAGCG	0.716													0	0	0	1	0	7	8										A	8583003	G	A	8583003	2	1	68	1	0	0	0	0	0	0	0	1	6710	1103	39	2		2	GPR78	4	8583003	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1388247	8583003	182571273	274	20794										
FGFBP2	83888	broad.mit.edu	37	chr4	15964632	15964632	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggacgcatagtgcaggaatCtctccctccagtctggaaat	11	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:15964632C>T	uc003gon.2	-	1	228	c.121G>A	c.(121-123)GAT>AAT	p.D41N		NM_031950	NP_114156	Q9BYJ0	FGFP2_HUMAN	killer-specific secretory protein of 37 kDa	41						extracellular space	growth factor binding				0						GTGCAGGAATCTCTCCCTCCA	0.582													0	0	0	1	0	15	38										T	15964632	C	T	15964632	3	4	68	1	0	0	0	0	1	0	0	0	5861	913	32	1	554	1	FGFBP2	4	15964632	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7381629	15964632	175189644	275	20795										
ARAP2	116984	broad.mit.edu	37	chr4	36122942	36122942	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgattgatttctgagcatttCtgaaccctgtcagagaaaag	9	7	3	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:36122942C>G	uc003gsq.1	-	23	4091	c.3753G>C	c.(3751-3753)CAG>CAC	p.Q1251H		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1251	Rho-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTGAGCATTTCTGAACCCTGT	0.338													0	0	0	1	0	27	77										G	36122942	C	G	36122942	3	3	68	1	0	0	0	0	1	0	0	0	839	912	32	1	1405	1	ARAP2	4	36122942	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	20158310	36122942	155031334	276	20796										
TLR10	81793	broad.mit.edu	37	chr4	38776990	38776990	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcatagaatcaaaactctCagtttggagacagaatgaaa	9	6	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:38776990C>G	uc003gti.2	-	2	601	c.222G>C	c.(220-222)CTG>CTC	p.L74L	TLR10_uc003gtj.2_Silent_p.L74L|TLR10_uc003gtk.2_Silent_p.L74L	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	74	LRR 3.|Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						TCAAAACTCTCAGTTTGGAGA	0.388													0	0	0	1	0	10	49										G	38776990	C	G	38776990	2	3	68	1	0	0	0	0	0	0	0	1	15947	813	29	1		1	TLR10	4	38776990	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2654048	38776990	152377286	277	20797										
KLB	152831	broad.mit.edu	37	chr4	39450291	39450291	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ataccattaaagaaaggcaaGagagttgttagctaaactga	9	5	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:39450291G>C	uc003gua.2	+	5	3217	c.3120G>C	c.(3118-3120)AAG>AAC	p.K1040N	KLB_uc011byj.1_Missense_Mutation_p.K1031N	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	1040	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						AGAAAGGCAAGAGAGTTGTTA	0.353													0	0	0	1	0	11	85										C	39450291	G	C	39450291	3	2	68	1	0	0	0	0	1	0	0	0	8332	933	33	1	3138	1	KLB	4	39450291	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	673301	39450291	151703985	278	20798										
N4BP2	55728	broad.mit.edu	37	chr4	40123716	40123716	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaaattttcagatgaagaaGaatttatgaatgaagatgag	10	1	1	9			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:40123716G>A	uc003guy.3	+	9	4323	c.3985G>A	c.(3985-3987)GAA>AAA	p.E1329K	N4BP2_uc010ifq.2_Missense_Mutation_p.E1249K|N4BP2_uc010ifr.2_Missense_Mutation_p.E1249K	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1329						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AGATGAAGAAGAATTTATGAA	0.289													0	0	0	1	0	30	63										A	40123716	G	A	40123716	3	1	68	1	0	0	0	0	1	0	0	0	10110	943	33	1	4011	1	N4BP2	4	40123716	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	673425	40123716	151030560	279	20799										
RBM47	54502	broad.mit.edu	37	chr4	40440385	40440385	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatcacgtccagcacgccctCggtgaccttggcaatctcct	9	16	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:40440385C>T	uc003gvc.2	-	4	1236	c.526G>A	c.(526-528)GAG>AAG	p.E176K	RBM47_uc003gvd.2_Missense_Mutation_p.E176K|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.E138K|RBM47_uc003gvg.1_Missense_Mutation_p.E176K	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	176	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						AGCACGCCCTCGGTGACCTTG	0.637													0	0	0	1	0	24	89										T	40440385	C	T	40440385	3	4	68	1	0	0	0	0	1	0	0	0	13141	893	31	1	1271	1	RBM47	4	40440385	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	316669	40440385	150713891	280	20800										
GABRB1	2560	broad.mit.edu	37	chr4	47163397	47163397	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtaccagacacctactttctGaatgacaagaaatcatttgt	6	9	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:47163397G>A	uc003gxh.2	+	4	746	c.372G>A	c.(370-372)CTG>CTA	p.L124L	GABRB1_uc011bze.1_Silent_p.L54L	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	124	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCTACTTTCTGAATGACAAGA	0.443													0	0	0	1	0	31	116										A	47163397	G	A	47163397	2	1	68	1	0	0	0	0	0	0	0	1	6166	1277	45	1		1	GABRB1	4	47163397	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6723012	47163397	143990879	281	20801										
LRRC66	339977	broad.mit.edu	37	chr4	52861501	52861501	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcttgagccagagacagcgtGagacgtgccagctacagaag	14	10	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:52861501G>T	uc003gzi.2	-	4	1700	c.1687C>A	c.(1687-1689)CAC>AAC	p.H563N		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	563						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GAGACAGCGTGAGACGTGCCA	0.483													1	0	2.79147e-13	1	3.15731e-13	52	120										T	52861501	G	T	52861501	3	4	68	1	0	0	0	0	1	0	0	0	9018	1290	45	3	959	3	LRRC66	4	52861501	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5698104	52861501	138292775	282	20802										
KIT	3815	broad.mit.edu	37	chr4	55570029	55570029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caataatacttttggatcagCaaatgtcacaacaaccttgg	6	9	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:55570029C>T	uc010igr.2	+	5	983	c.896C>T	c.(895-897)GCA>GTA	p.A299V	KIT_uc010igs.2_Missense_Mutation_p.A299V	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	299	Extracellular (Potential).|Ig-like C2-type 3.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TTTGGATCAGCAAATGTCACA	0.358		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	1	0	17	103										T	55570029	C	T	55570029	3	4	68	1	0	0	0	0	1	0	0	0	8329	710	25	2	914	2	KIT	4	55570029	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2708528	55570029	135584247	283	20803										
KDR	3791	broad.mit.edu	37	chr4	55961025	55961025	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccacaaatccagagctggctGagctctggctactggtgatg	12	11	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:55961025G>A	uc003has.2	-	21	3217	c.2915C>T	c.(2914-2916)TCA>TTA	p.S972L	KDR_uc003hat.1_Missense_Mutation_p.S972L	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	972	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGAGCTGGCTGAGCTCTGGCT	0.527			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	1	0	34	81										A	55961025	G	A	55961025	3	1	68	1	0	0	0	0	1	0	0	0	8139	1294	45	1	1195	1	KDR	4	55961025	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	390996	55961025	135193251	284	20804										
KDR	3791	broad.mit.edu	37	chr4	55968171	55968171	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctgcggatagtgaggttcCggttcccatccttcaataca	9	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:55968171C>T	uc003has.2	-	15	2461	c.2159G>A	c.(2158-2160)CGG>CAG	p.R720Q	KDR_uc003hat.1_Missense_Mutation_p.R720Q	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	720	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGTGAGGTTCCGGTTCCCATC	0.438			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	1	0	18	95										T	55968171	C	T	55968171	3	4	68	1	0	0	0	0	1	0	0	0	8139	652	23	2	1975	2	KDR	4	55968171	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7146	55968171	135186105	285	20805										
TECRL	253017	broad.mit.edu	37	chr4	65147237	65147237	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accaggaaaaacatccatgtGaaggggttataatttggact	10	6	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:65147237G>A	uc003hcv.2	-	10	982	c.873C>T	c.(871-873)TTC>TTT	p.F291F	TECRL_uc010ihi.2_RNA	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	291					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						ACATCCATGTGAAGGGGTTAT	0.338													0	0	0	1	0	11	60										A	65147237	G	A	65147237	2	1	68	1	0	0	0	0	0	0	0	1	15743	1281	45	1		1	TECRL	4	65147237	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9179066	65147237	126007039	286	20806										
UGT2B10	7365	broad.mit.edu	37	chr4	69885667	69885667	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcatctgcaaaaacgatgtCaaatcttgactcttgtagtt	7	8	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:69885667C>G	uc011cao.1	-	4	458	c.322G>C	c.(322-324)GAC>CAC	p.D108H	UGT2B10_uc011can.1_Missense_Mutation_p.D108H			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	145					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						AAAACGATGTCAAATCTTGAC	0.368													0	0	0	1	0	22	83										G	69885667	C	G	69885667	3	3	68	1	0	0	0	0	1	0	0	0	16953	837	29	1	2788	1	UGT2B10	4	69885667	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4738430	69885667	121268609	287	20807										
UGT2B28	54490	broad.mit.edu	37	chr4	70146759	70146759	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcactcctggctacacaattGaaaggcacagtggaggactg	11	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:70146759G>A	uc003hej.2	+	1	543	c.541G>A	c.(541-543)GAA>AAA	p.E181K	UGT2B28_uc010ihr.2_Missense_Mutation_p.E181K	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	181					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	CTACACAATTGAAAGGCACAG	0.418													0	0	0	1	0	47	31										A	70146759	G	A	70146759	3	1	68	1	0	0	0	0	1	0	0	0	16957	1291	45	1	543	1	UGT2B28	4	70146759	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	261092	70146759	121007517	288	20808										
ADAMTS3	9508	broad.mit.edu	37	chr4	73179451	73179451	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagttccacatgtccgagaaCaggagccaaatttagtccat	8	11	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:73179451C>G	uc003hgk.1	-	12	1725	c.1688G>C	c.(1687-1689)TGT>TCT	p.C563S	ADAMTS3_uc003hgl.2_5'Flank	NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	563	TSP type-1 1.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGTCCGAGAACAGGAGCCAAA	0.423													0	0	0	1	0	21	43										G	73179451	C	G	73179451	3	3	68	1	0	0	0	0	1	0	0	0	267	478	17	4	1973	4	ADAMTS3	4	73179451	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3032692	73179451	117974825	289	20809										
SHROOM3	57619	broad.mit.edu	37	chr4	77660799	77660799	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgagtagcaacggtatgctCtaccctgcactggccaagga	12	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:77660799C>A	uc011cbx.1	+	5	2426	c.1473C>A	c.(1471-1473)CTC>CTA	p.L491L	SHROOM3_uc011cbz.1_Silent_p.L315L|SHROOM3_uc003hkf.1_Silent_p.L366L|SHROOM3_uc003hkg.2_Silent_p.L269L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	491					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			ACGGTATGCTCTACCCTGCAC	0.562													1	0	9.16793e-09	1	9.97547e-09	16	86										A	77660799	C	A	77660799	2	1	68	1	0	0	0	0	0	0	0	1	14295	900	32	3		3	SHROOM3	4	77660799	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4481348	77660799	113493477	290	20810										
SEPT11	55752	broad.mit.edu	37	chr4	77933056	77933056	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccctggatctggtcaccatGaaaaagctggacagtaaggt	11	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:77933056G>C	uc003hkj.2	+	4	669	c.507G>C	c.(505-507)ATG>ATC	p.M169I	SEPT11_uc010ijh.1_Missense_Mutation_p.M161I|SEPT11_uc011cca.1_Missense_Mutation_p.M179I|SEPT11_uc003hkk.1_5'Flank	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	169					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						TGGTCACCATGAAAAAGCTGG	0.433													0	0	0	1	0	12	74										C	77933056	G	C	77933056	3	2	68	1	0	0	0	0	1	0	0	0	14061	1290	45	1	521	1	SEPT11	4	77933056	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	272257	77933056	113221220	291	20811										
SEPT11	55752	broad.mit.edu	37	chr4	77941663	77941663	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctctcttgtagttgagaatGaaaatcattgcgattttgtg	9	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:77941663G>A	uc003hkj.2	+	7	955	c.793G>A	c.(793-795)GAA>AAA	p.E265K	SEPT11_uc010ijh.1_Missense_Mutation_p.E257K|SEPT11_uc011cca.1_Missense_Mutation_p.E275K|SEPT11_uc003hkk.1_Missense_Mutation_p.E65K	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	265					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						AGTTGAGAATGAAAATCATTG	0.458													0	0	0	1	0	13	93										A	77941663	G	A	77941663	3	1	68	1	0	0	0	0	1	0	0	0	14061	1291	45	1	819	1	SEPT11	4	77941663	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8607	77941663	113212613	292	20812										
SEC31A	22872	broad.mit.edu	37	chr4	83788011	83788011	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccacttgggcggcttcttcaGaggcagcactatactatgct	10	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:83788011G>A	uc003hnf.2	-	10	1311	c.1147C>T	c.(1147-1149)CTG>TTG	p.L383L	SEC31A_uc003hne.2_Silent_p.L155L|SEC31A_uc011ccl.1_Silent_p.L383L|SEC31A_uc003hnl.2_Silent_p.L383L|SEC31A_uc003hng.2_Silent_p.L383L|SEC31A_uc003hnh.2_Silent_p.L383L|SEC31A_uc003hni.2_Silent_p.L383L|SEC31A_uc003hnj.2_Silent_p.L383L|SEC31A_uc011ccm.1_Silent_p.L378L|SEC31A_uc011ccn.1_Silent_p.L383L|SEC31A_uc003hnk.2_Silent_p.L383L|SEC31A_uc003hnm.2_Silent_p.L383L|SEC31A_uc003hnn.1_Silent_p.L383L|SEC31A_uc003hno.2_Silent_p.L383L	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	383	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GGCTTCTTCAGAGGCAGCACT	0.458													0	0	0	1	0	43	135										A	83788011	G	A	83788011	2	1	68	1	0	0	0	0	0	0	0	1	13998	933	33	1		1	SEC31A	4	83788011	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5846348	83788011	107366265	293	20813										
CDS1	1040	broad.mit.edu	37	chr4	85556483	85556483	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacctttttggattttttttTgggagaactccattaattaa	6	5	0	1	rs141889582		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:85556483T>G	uc011ccv.1	+	8	1287	c.789T>G	c.(787-789)TTT>TTG	p.F263L	CDS1_uc010ike.1_Missense_Mutation_p.F67L	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	263					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity	p.G264fs*7(2)		large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		GATTTTTTTTTGGGAGAACTC	0.318													0	0	0	1	0	15	85										G	85556483	T	G	85556483	3	3	68	1	0	0	0	0	1	0	0	0	3177	1809	63	5	819	5	CDS1	4	85556483	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	1768472	85556483	105597793	294	20814										
AFF1	4299	broad.mit.edu	37	chr4	88036295	88036295	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccccacaaagcttgatggtGaagatcaccctagacctgct	8	14	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:88036295G>A	uc003hqj.3	+	11	2696	c.2289G>A	c.(2287-2289)GTG>GTA	p.V763V	AFF1_uc011ccz.1_Silent_p.V770V|AFF1_uc003hqk.3_Silent_p.V763V|AFF1_uc011cda.1_Silent_p.V401V	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	763						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCTTGATGGTGAAGATCACCC	0.592													0	0	0	1	0	15	61										A	88036295	G	A	88036295	2	1	68	1	0	0	0	0	0	0	0	1	356	1277	45	1		1	AFF1	4	88036295	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2479812	88036295	103117981	295	20815										
SPARCL1	8404	broad.mit.edu	37	chr4	88394928	88394928	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttctttaaaatcttcgttCaaaacaagagattttcatct	4	7	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:88394928C>G	uc010ikm.2	-	12	2566	c.1994G>C	c.(1993-1995)TGA>TCA	p.*665S	SPARCL1_uc011cdc.1_Nonstop_Mutation_p.*540S|SPARCL1_uc003hqs.3_Nonstop_Mutation_p.*665S|SPARCL1_uc011cdd.1_Nonstop_Mutation_p.*540S	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	665					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		AATCTTCGTTCAAAACAAGAG	0.323													0	0	0	1	0	15	93										G	88394928	C	G	88394928	4	3	68	1	0	0	0	0	0	0	0	0	14995	837	29	1	4	1	SPARCL1	4	88394928	Nonstop_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	358633	88394928	102759348	296	20816										
ADH1B	125	broad.mit.edu	37	chr4	100235088	100235088	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcttgagggttgatgcattCagtggcacccaactctttgg	12	9	3	2	rs75973598		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:100235088C>T	uc003hus.3	-	6	802	c.718G>A	c.(718-720)GAA>AAA	p.E240K	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.E200K|ADH1B_uc011ceh.1_Missense_Mutation_p.E85K|ADH1B_uc011cei.1_Missense_Mutation_p.E200K	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	240					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTGATGCATTCAGTGGCACCC	0.468													0	0	0	1	0	77	427										T	100235088	C	T	100235088	3	4	68	1	0	0	0	0	1	0	0	0	308	835	29	1	425	1	ADH1B	4	100235088	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	11840160	100235088	90919188	297	20817										
TACR3	6870	broad.mit.edu	37	chr4	104640753	104640753	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggccgccccggcagctagcGaggcggtcaggttcacggcg	17	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:104640753G>A	uc003hxe.1	-	1	223	c.80C>T	c.(79-81)TCG>TTG	p.S27L		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	27	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GGCAGCTAGCGAGGCGGTCAG	0.682													0	0	0	1	0	7	49										A	104640753	G	A	104640753	3	1	68	1	0	0	0	0	1	0	0	0	15504	1059	37	1	1337	1	TACR3	4	104640753	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4405665	104640753	86513523	298	20818										
TBCK	93627	broad.mit.edu	37	chr4	107165844	107165844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttgttgacaagctctttctCcaagtcacctccagccaaac	5	15	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:107165844C>T	uc010ilv.2	-	11	1374	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	TBCK_uc003hyb.2_Missense_Mutation_p.E80K|TBCK_uc003hye.2_Missense_Mutation_p.E298K|TBCK_uc003hyc.2_Missense_Mutation_p.E274K|TBCK_uc003hyd.2_Missense_Mutation_p.E165K|TBCK_uc003hyf.2_Missense_Mutation_p.E337K	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	337						intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						AGCTCTTTCTCCAAGTCACCT	0.353													0	0	0	1	0	21	71										T	107165844	C	T	107165844	3	4	68	1	0	0	0	0	1	0	0	0	15633	864	30	1	1736	1	TBCK	4	107165844	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2525091	107165844	83988432	299	20819										
KIAA1109	84162	broad.mit.edu	37	chr4	123118351	123118351	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taatttttttcttttggtagGaaacaaatgctgtacatgta	7	4	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:123118351G>C	uc003ieh.2	+	11	1255	c.1210G>C	c.(1210-1212)GAA>CAA	p.E404Q	KIAA1109_uc003iei.1_Missense_Mutation_p.E158Q|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	404					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTTTTGGTAGGAAACAAATGC	0.249													0	0	0	1	0	16	49										C	123118351	G	C	123118351	3	2	68	1	0	0	0	0	1	0	0	0	8208	1188	41	1	1252	1	KIAA1109	4	123118351	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	15952507	123118351	68035925	300	20820										
FAT4	79633	broad.mit.edu	37	chr4	126367492	126367492	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagttcacgatcaacccatCgacaggacaaatcatcacca	5	14	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:126367492C>T	uc003ifj.3	+	8	7238	c.7238C>T	c.(7237-7239)TCG>TTG	p.S2413L	FAT4_uc011cgp.1_Missense_Mutation_p.S711L|FAT4_uc003ifi.1_5'Flank	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2413	Cadherin 23.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATCAACCCATCGACAGGACAA	0.408													0	0	0	1	0	15	109										T	126367492	C	T	126367492	3	4	68	1	0	0	0	0	1	0	0	0	5692	893	31	1	7268	1	FAT4	4	126367492	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3249141	126367492	64786784	301	20821										
PCDH18	54510	broad.mit.edu	37	chr4	138452282	138452282	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgagcctgaacatcaatctCataggatttggtgatttcat	8	7	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:138452282C>T	uc003ihe.3	-	1	1348	c.961G>A	c.(961-963)GAG>AAG	p.E321K	PCDH18_uc003ihf.3_Missense_Mutation_p.E314K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E101K|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	321	Cadherin 3.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					ACATCAATCTCATAGGATTTG	0.343													0	0	0	1	0	10	58										T	138452282	C	T	138452282	3	4	68	1	0	0	0	0	1	0	0	0	11513	835	29	1	2462	1	PCDH18	4	138452282	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	12084790	138452282	52701994	302	20822										
TBC1D9	23158	broad.mit.edu	37	chr4	141677148	141677148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaagtatgggttggccctctCggtgatccacagcgcgttgg	15	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:141677148C>T	uc010ioj.2	-	1	324	c.52G>A	c.(52-54)GAG>AAG	p.E18K		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	18						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TTGGCCCTCTCGGTGATCCAC	0.701													0	0	0	1	0	5	12										T	141677148	C	T	141677148	3	4	68	1	0	0	0	0	1	0	0	0	15624	893	31	1	3832	1	TBC1D9	4	141677148	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3224866	141677148	49477128	303	20823										
PRMT10	90826	broad.mit.edu	37	chr4	148575400	148575400	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtctgatacagtttctctgGagtcagtgaagacaaaactt	10	7	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:148575400G>C	uc003ilc.2	-	9	1790	c.1648C>G	c.(1648-1650)CCA>GCA	p.P550A	PRMT10_uc003ilb.2_Missense_Mutation_p.P194A|PRMT10_uc003ild.2_Missense_Mutation_p.P437A	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	550						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						AGTTTCTCTGGAGTCAGTGAA	0.388													0	0	0	1	0	31	95										C	148575400	G	C	148575400	3	2	68	1	0	0	0	0	1	0	0	0	12536	1174	41	1	905	1	PRMT10	4	148575400	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6898252	148575400	42578876	304	20824										
FHDC1	85462	broad.mit.edu	37	chr4	153896615	153896615	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtgccagcagcagcagcctGacacccatgggcagagatgc	13	13	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:153896615G>A	uc003inf.2	+	11	2247	c.2172G>A	c.(2170-2172)CTG>CTA	p.L724L		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	724					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GCAGCAGCCTGACACCCATGG	0.637													0	0	0	1	0	18	17										A	153896615	G	A	153896615	2	1	68	1	0	0	0	0	0	0	0	1	5876	1277	45	1		1	FHDC1	4	153896615	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5321215	153896615	37257661	305	20825										
GLRB	2743	broad.mit.edu	37	chr4	158074052	158074052	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accccaaaagggttgaagctGaaaaagccagaattgctaag	10	8	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:158074052G>A	uc003ipj.2	+	9	1289	c.1087G>A	c.(1087-1089)GAA>AAA	p.E363K		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	363	Cytoplasmic (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GGTTGAAGCTGAAAAAGCCAG	0.448													0	0	0	1	0	27	54										A	158074052	G	A	158074052	3	1	68	1	0	0	0	0	1	0	0	0	6458	1291	45	1	1117	1	GLRB	4	158074052	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4177437	158074052	33080224	306	20826										
GRIA2	2891	broad.mit.edu	37	chr4	158255240	158255240	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaaatgacacctctgggcttGagaataagactgttgttgtc	11	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:158255240G>C	uc003ipm.3	+	9	1693	c.1234G>C	c.(1234-1236)GAG>CAG	p.E412Q	GRIA2_uc011cit.1_Missense_Mutation_p.E365Q|GRIA2_uc003ipl.3_Missense_Mutation_p.E412Q|GRIA2_uc003ipk.3_Missense_Mutation_p.E365Q|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	412	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CTCTGGGCTTGAGAATAAGAC	0.403													0	0	0	1	0	10	78										C	158255240	G	C	158255240	3	2	68	1	0	0	0	0	1	0	0	0	6768	1291	45	1	1268	1	GRIA2	4	158255240	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	181188	158255240	32899036	307	20827										
FAM198B	51313	broad.mit.edu	37	chr4	159092464	159092464	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctccagagcttacgcacccGcgggacgcacagggagcaga	14	14	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:159092464G>A	uc003ipp.3	-	2	516	c.64C>T	c.(64-66)CGG>TGG	p.R22W	uc003ipu.1_5'Flank|FAM198B_uc003ipq.3_Missense_Mutation_p.R22W|FAM198B_uc003ipr.3_Missense_Mutation_p.R22W|FAM198B_uc003ips.2_Missense_Mutation_p.R22W|uc003ipt.1_RNA	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	22	Cytoplasmic (Potential).					Golgi membrane|integral to membrane					0						TTACGCACCCGCGGGACGCAC	0.587													0	0	0	1	0	26	50										A	159092464	G	A	159092464	3	1	68	1	0	0	0	0	1	0	0	0	5529	1086	38	2	1616	2	FAM198B	4	159092464	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	837224	159092464	32061812	308	20828										
GLRA3	8001	broad.mit.edu	37	chr4	175649820	175649820	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggcggggatcattccatttCtgacgaagaaagatattcac	10	8	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:175649820C>G	uc003ity.1	-	4	800	c.297G>C	c.(295-297)CAG>CAC	p.Q99H	GLRA3_uc003itz.1_Missense_Mutation_p.Q99H	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	99	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	CATTCCATTTCTGACGAAGAA	0.378													0	0	0	1	0	15	89										G	175649820	C	G	175649820	3	3	68	1	0	0	0	0	1	0	0	0	6456	912	32	1	1125	1	GLRA3	4	175649820	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	16557356	175649820	15504456	309	20829										
WDR17	116966	broad.mit.edu	37	chr4	177098691	177098691	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atttatgcaactttattaaaGagactaaaagaagagtcact	6	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:177098691G>C	uc003iuj.2	+	30	3891	c.3735G>C	c.(3733-3735)AAG>AAC	p.K1245N	WDR17_uc003iuk.2_Missense_Mutation_p.K1221N|WDR17_uc003ium.3_Missense_Mutation_p.K1206N|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.K456N	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1245										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTTTATTAAAGAGACTAAAAG	0.328													0	0	0	1	0	16	92										C	177098691	G	C	177098691	3	2	68	1	0	0	0	0	1	0	0	0	17274	933	33	1	3849	1	WDR17	4	177098691	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1448871	177098691	14055585	310	20830										
C4orf41	60684	broad.mit.edu	37	chr4	184605510	184605510	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaggattataccaaagctttGaagtgagtcctgttcactat	8	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:184605510G>A	uc003ivx.2	+	14	1595	c.1419G>A	c.(1417-1419)TTG>TTA	p.L473L	C4orf41_uc003ivw.2_Silent_p.L473L|C4orf41_uc010isc.2_Intron|C4orf41_uc003ivy.2_Silent_p.L79L	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	473											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		CCAAAGCTTTGAAGTGAGTCC	0.303													0	0	0	1	0	23	42										A	184605510	G	A	184605510	2	1	68	1	0	0	0	0	0	0	0	1	2270	1281	45	1		1	C4orf41	4	184605510	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7506819	184605510	6548766	311	20831										
TLR3	7098	broad.mit.edu	37	chr4	187005024	187005024	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcatccactttgagggctgGaggatatctttttattggaa	10	7	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr4:187005024G>C	uc003iyq.2	+	4	2285	c.2184G>C	c.(2182-2184)TGG>TGC	p.W728C	TLR3_uc011ckz.1_Missense_Mutation_p.W451C|TLR3_uc003iyr.2_Missense_Mutation_p.W451C	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	728	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TTGAGGGCTGGAGGATATCTT	0.358													0	0	0	1	0	78	132										C	187005024	G	C	187005024	3	2	68	1	0	0	0	0	1	0	0	0	15949	1183	41	1	2194	1	TLR3	4	187005024	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2399514	187005024	4149252	312	20832										
KIAA0947	23379	broad.mit.edu	37	chr5	5462600	5462600	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctaatggactttggaaattGaaatctacaactcccggtgg	10	8	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:5462600G>A	uc003jdm.3	+	13	3375	c.3153G>A	c.(3151-3153)TTG>TTA	p.L1051L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1051										ovary(1)|central_nervous_system(1)	2						TTTGGAAATTGAAATCTACAA	0.463													0	0	0	1	0	40	140										A	5462600	G	A	5462600	2	1	68	1	0	0	0	0	0	0	0	1	8202	1281	45	1		1	KIAA0947	5	5462600	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		5462600	175452660	313	20833										
CDH10	1008	broad.mit.edu	37	chr5	24535867	24535867	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaagtatgctgtaaatgacTctggcgctgttcccatatga	10	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:24535867T>C	uc003jgr.1	-	4	923	c.591A>G	c.(589-591)AGA>AGG	p.R197R	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	197	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TGTAAATGACTCTGGCGCTGT	0.443										HNSCC(23;0.051)			0	0	0	1	0	9	86										C	24535867	T	C	24535867	2	2	68	1	0	0	0	0	0	0	0	1	3096	1548	54	5		5	CDH10	5	24535867	Silent	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	19073267	24535867	156379393	314	20834										
ADAMTS12	81792	broad.mit.edu	37	chr5	33662105	33662105	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctgccacttgcagaagctaGacagtgtcttttctgcatgg	10	10	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:33662105G>C	uc003jia.1	-	6	1119	c.956C>G	c.(955-957)TCT>TGT	p.S319C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S319C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	319	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GCAGAAGCTAGACAGTGTCTT	0.488										HNSCC(64;0.19)			0	0	0	1	0	31	69										C	33662105	G	C	33662105	3	2	68	1	0	0	0	0	1	0	0	0	257	942	33	1	3904	1	ADAMTS12	5	33662105	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9126238	33662105	147253155	315	20835										
ADAMTS12	81792	broad.mit.edu	37	chr5	33662118	33662118	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaagctagacagtgtcttttCtgcatggtgaactattttca	9	7	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:33662118C>T	uc003jia.1	-	6	1106	c.943G>A	c.(943-945)GAA>AAA	p.E315K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E315K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	315	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGTGTCTTTTCTGCATGGTGA	0.473										HNSCC(64;0.19)			0	0	0	1	0	23	75										T	33662118	C	T	33662118	3	4	68	1	0	0	0	0	1	0	0	0	257	922	32	1	3917	1	ADAMTS12	5	33662118	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	13	33662118	147253142	316	20836										
TTC23L	153657	broad.mit.edu	37	chr5	34867123	34867123	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtacgaggaagctgctcaGatagagcagctgaggaggaa	15	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:34867123G>A	uc003jiu.2	+	7	892	c.789G>A	c.(787-789)CAG>CAA	p.Q263Q	TTC23L_uc003jiv.2_Silent_p.Q70Q|TTC23L_uc010iut.1_Silent_p.Q70Q	NM_144725	NP_653326	Q6PF05	TT23L_HUMAN	tetratricopeptide repeat domain 23-like	263	Potential.						binding			central_nervous_system(1)	1						AAGCTGCTCAGATAGAGCAGC	0.547													0	0	0	1	0	5	18										A	34867123	G	A	34867123	2	1	68	1	0	0	0	0	0	0	0	1	16688	933	33	1		1	TTC23L	5	34867123	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1205005	34867123	146048137	317	20837										
LMBRD2	92255	broad.mit.edu	37	chr5	36141289	36141289	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggaatgtaactccatggcttGaaacaaggatgctggctgtt	12	7	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:36141289G>A	uc003jkb.1	-	4	703	c.288C>T	c.(286-288)TTC>TTT	p.F96F		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	96	Extracellular (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCCATGGCTTGAAACAAGGAT	0.333													0	0	0	1	0	11	65										A	36141289	G	A	36141289	2	1	68	1	0	0	0	0	0	0	0	1	8843	1281	45	1		1	LMBRD2	5	36141289	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1274166	36141289	144773971	318	20838										
LIFR	3977	broad.mit.edu	37	chr5	38481806	38481806	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaaattgtcgggaattaatgGagcatggacttccaaatgag	11	5	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:38481806G>A	uc010ive.1	-	20	3517	c.3185C>T	c.(3184-3186)TCC>TTC	p.S1062F	LIFR_uc003jli.2_Missense_Mutation_p.S1062F	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	1062	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					GGAATTAATGGAGCATGGACT	0.403			T	PLAG1	salivary adenoma								0	0	0	1	0	20	203										A	38481806	G	A	38481806	3	1	68	1	0	0	0	0	1	0	0	0	8780	1174	41	1	112	1	LIFR	5	38481806	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2340517	38481806	142433454	319	20839										
CCNB1	891	broad.mit.edu	37	chr5	68473423	68473423	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacagctgaattctgcactaGttcaagatttagccaaggct	8	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:68473423G>C	uc003jvm.2	+	9	1444	c.1267G>C	c.(1267-1269)GTT>CTT	p.V423L	CCNB1_uc010ixb.2_Missense_Mutation_p.V386L	NM_031966	NP_114172	P14635	CCNB1_HUMAN	cyclin B1	423					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole					0		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		TTCTGCACTAGTTCAAGATTT	0.393													0	0	0	1	0	52	56										C	68473423	G	C	68473423	3	2	68	1	0	0	0	0	1	0	0	0	2911	1029	36	4	1301	4	CCNB1	5	68473423	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	29991617	68473423	112441837	320	20840										
MCCC2	64087	broad.mit.edu	37	chr5	70928012	70928012	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggtgctgatcttcattgcaGgtgaaacagaaatggttgtt	12	5	2	3	rs119103223		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:70928012G>A	uc003kbs.3	+	8	941	c.803G>A	c.(802-804)AGA>AAA	p.R268K	MCCC2_uc010iyv.1_Missense_Mutation_p.R268K|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.R137K	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	268	Carboxyltransferase.		R -> T (in MCC2 deficiency; asymptomatic form).		leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	CTTCATTGCAGGTGAAACAGA	0.398													0	0	0	1	0	33	47										A	70928012	G	A	70928012	3	1	68	1	0	0	0	0	1	0	0	0	9375	1014	35	2	833	2	MCCC2	5	70928012	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2454589	70928012	109987248	321	20841										
HMGCR	3156	broad.mit.edu	37	chr5	74643117	74643117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgttgaatgtcttgtgattgGagttggtaccatgtcaggtt	13	4	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:74643117G>A	uc003kdp.2	+	6	695	c.539G>A	c.(538-540)GGA>GAA	p.G180E	HMGCR_uc011cst.1_Missense_Mutation_p.G200E|HMGCR_uc003kdq.2_Missense_Mutation_p.G180E|HMGCR_uc010izn.1_Missense_Mutation_p.G20E	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	180	Helical; (Potential).				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CTTGTGATTGGAGTTGGTACC	0.353													0	0	0	1	0	79	84										A	74643117	G	A	74643117	3	1	68	1	0	0	0	0	1	0	0	0	7231	1174	41	1	557	1	HMGCR	5	74643117	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3715105	74643117	106272143	322	20842										
TBCA	6902	broad.mit.edu	37	chr5	76989151	76989151	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgctggcaatctgggatcatCatcctggattcttgtaggat	11	9	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:76989151C>A	uc003kfh.1	-	3	290	c.186G>T	c.(184-186)ATG>ATT	p.M62I	TBCA_uc003kfi.1_Missense_Mutation_p.M62I	NM_004607	NP_004598	O75347	TBCA_HUMAN	tubulin-specific chaperone a	62					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway|tubulin complex assembly	cytoplasm|microtubule	chaperone binding|unfolded protein binding			ovary(1)	1		all_lung(232;0.000511)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.02e-49)|Epithelial(54;1.05e-44)|all cancers(79;4.08e-40)		CTGGGATCATCATCCTGGATT	0.403													1	0	1.58986e-06	1	1.6848e-06	9	26										A	76989151	C	A	76989151	3	1	68	1	0	0	0	0	1	0	0	0	15626	826	29	3	148	3	TBCA	5	76989151	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2346034	76989151	103926109	323	20843										
ERAP2	64167	broad.mit.edu	37	chr5	96215522	96215522	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctcagtgccatctagttatCacttcactgaggatcctggg	9	11	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:96215522C>T	uc003kmq.2	+	2	843	c.133C>T	c.(133-135)CAC>TAC	p.H45Y	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.H45Y|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.H39Y|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	45	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		ATCTAGTTATCACTTCACTGA	0.458													0	0	0	1	0	14	39										T	96215522	C	T	96215522	3	4	68	1	0	0	0	0	1	0	0	0	5204	826	29	1	135	1	ERAP2	5	96215522	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	19226371	96215522	84699738	324	20844										
HSPA4	3308	broad.mit.edu	37	chr5	132424172	132424172	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctgcggtaaaagagaagatCagcaaatttttcggtaaaga	10	6	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:132424172C>T	uc003kyj.2	+	9	1343	c.1062C>T	c.(1060-1062)ATC>ATT	p.I354I		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	354					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGAGAAGATCAGCAAATTTT	0.358													0	0	0	1	0	24	36										T	132424172	C	T	132424172	2	4	68	1	0	0	0	0	0	0	0	1	7412	816	29	1		1	HSPA4	5	132424172	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	36208650	132424172	48491088	325	20845										
HSPA4	3308	broad.mit.edu	37	chr5	132424226	132424226	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttaaatgctgatgaagctgtCactcgaggctgtgcattgca	11	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:132424226C>G	uc003kyj.2	+	9	1397	c.1116C>G	c.(1114-1116)GTC>GTG	p.V372V		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	372					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATGAAGCTGTCACTCGAGGCT	0.368													0	0	0	1	0	33	44										G	132424226	C	G	132424226	2	3	68	1	0	0	0	0	0	0	0	1	7412	813	29	1		1	HSPA4	5	132424226	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	54	132424226	48491034	326	20846										
MYOT	9499	broad.mit.edu	37	chr5	137213275	137213275	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agaatgcagctgctgtgtttCaagctcaggatgacagtggt	13	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:137213275C>G	uc011cye.1	+	4	615	c.598C>G	c.(598-600)CAA>GAA	p.Q200E	MYOT_uc003lbv.2_Missense_Mutation_p.Q200E|MYOT_uc011cyg.1_Missense_Mutation_p.Q16E|MYOT_uc011cyh.1_Missense_Mutation_p.Q85E	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	200					muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGCTGTGTTTCAAGCTCAGGA	0.388													0	0	0	1	0	13	50										G	137213275	C	G	137213275	3	3	68	1	0	0	0	0	1	0	0	0	10094	827	29	1	608	1	MYOT	5	137213275	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4789049	137213275	43701985	327	20847										
NME5	8382	broad.mit.edu	37	chr5	137474391	137474391	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aatatcttgtatctcctcctCtttgtcaacaatatctggtt	4	10	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:137474391C>T	uc003lce.2	-	2	157	c.79G>A	c.(79-81)GAG>AAG	p.E27K	BRD8_uc003lcc.1_Intron	NM_003551	NP_003542	P56597	NDK5_HUMAN	non-metastatic cells 5, protein expressed in	27					anti-apoptosis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatid development|UTP biosynthetic process		ATP binding|nucleoside diphosphate kinase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATCTCCTCCTCTTTGTCAACA	0.378													0	0	0	1	0	18	30										T	137474391	C	T	137474391	3	4	68	1	0	0	0	0	1	0	0	0	10494	922	32	1	579	1	NME5	5	137474391	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	261116	137474391	43440869	328	20848										
CDC25C	995	broad.mit.edu	37	chr5	137622209	137622209	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgggggcccctctctgaggaGaattcacagtggaacacgat	13	11	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:137622209G>A	uc003lcp.1	-	12	1408	c.1137C>T	c.(1135-1137)TTC>TTT	p.F379F	CDC25C_uc003lcq.1_Silent_p.F306F|CDC25C_uc003lcr.1_Silent_p.F379F|CDC25C_uc011cyp.1_Silent_p.F396F|CDC25C_uc003lcs.1_Silent_p.F457F	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	379	HIV-1 Vpr binding site.|Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			TCTCTGAGGAGAATTCACAGT	0.468													0	0	0	1	0	16	48										A	137622209	G	A	137622209	2	1	68	1	0	0	0	0	0	0	0	1	3064	933	33	1		1	CDC25C	5	137622209	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	147818	137622209	43293051	329	20849										
PCDHB13	56123	broad.mit.edu	37	chr5	140594200	140594200	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgtaggccaaaacaatattGagaactatataatcagcccc	6	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:140594200G>A	uc003lja.1	+	1	692	c.505G>A	c.(505-507)GAG>AAG	p.E169K		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	169	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAACAATATTGAGAACTATAT	0.478													0	0	0	1	0	37	53										A	140594200	G	A	140594200	3	1	68	1	0	0	0	0	1	0	0	0	11538	1291	45	1	507	1	PCDHB13	5	140594200	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2971991	140594200	40321060	330	20850										
SH3RF2	153769	broad.mit.edu	37	chr5	145442003	145442003	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgcagcaagtcaaaaccgtGagatttcagaattacagccc	8	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:145442003G>T	uc003lnt.2	+	10	2167	c.1929G>T	c.(1927-1929)GTG>GTT	p.V643V	SH3RF2_uc011dbl.1_Silent_p.V643V|SH3RF2_uc003lnu.2_Silent_p.V134V|SH3RF2_uc011dbn.1_Silent_p.V134V|SH3RF2_uc011dbo.1_Silent_p.V100V	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	643	Interaction with PPP1CA.			V->G: Significant loss of interaction with PPP1CA. Significant loss of interaction with PPP1CA; when associated with G-645.			ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAAAACCGTGAGATTTCAGA	0.522													1	0	1.10513e-12	1	1.24661e-12	22	113										T	145442003	G	T	145442003	2	4	68	1	0	0	0	0	0	0	0	1	14259	1277	45	3		3	SH3RF2	5	145442003	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4847803	145442003	35473257	331	20851										
AFAP1L1	134265	broad.mit.edu	37	chr5	148687015	148687015	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgagtcctacgatgaagagGaggaggaagggaagagcccg	17	6	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:148687015G>C	uc003lqh.2	+	7	717	c.586G>C	c.(586-588)GAG>CAG	p.E196Q	AFAP1L1_uc003lqg.3_Missense_Mutation_p.E196Q|AFAP1L1_uc010jgy.2_Missense_Mutation_p.E196Q	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	196	Poly-Glu.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGATGAAGAGGAGGAGGAAGG	0.587													0	0	0	1	0	15	86										C	148687015	G	C	148687015	3	2	68	1	0	0	0	0	1	0	0	0	354	1175	41	1	612	1	AFAP1L1	5	148687015	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3245012	148687015	32228245	332	20852										
FAT2	2196	broad.mit.edu	37	chr5	150901233	150901233	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggtcactcaccagctcctCgggggtgagctggtagaagc	15	11	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:150901233C>T	uc003lue.3	-	18	10934	c.10921G>A	c.(10921-10923)GAG>AAG	p.E3641K	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.E334K	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3641	Cadherin 32.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCAGCTCCTCGGGGGTGAGC	0.607													0	0	0	1	0	8	35										T	150901233	C	T	150901233	3	4	68	1	0	0	0	0	1	0	0	0	5690	893	31	1	2152	1	FAT2	5	150901233	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2214218	150901233	30014027	333	20853										
GEMIN5	25929	broad.mit.edu	37	chr5	154272068	154272068	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caggaggccatctgttggctCagcactgccagggtcaagtc	13	12	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:154272068C>T	uc003lvx.3	-	25	3722	c.3639G>A	c.(3637-3639)CTG>CTA	p.L1213L	GEMIN5_uc011ddk.1_Silent_p.L1212L	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1213					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCTGTTGGCTCAGCACTGCCA	0.587													0	0	0	1	0	9	40										T	154272068	C	T	154272068	2	4	68	1	0	0	0	0	0	0	0	1	6331	813	29	1		1	GEMIN5	5	154272068	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3370835	154272068	26643192	334	20854										
TIMD4	91937	broad.mit.edu	37	chr5	156375436	156375436	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcccccctacctccaggctGaggagaagacacagaatcac	9	15	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:156375436G>A	uc003lwh.2	-	5	892	c.835C>T	c.(835-837)CAG>TAG	p.Q279*	TIMD4_uc010jii.2_Intron	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	279	Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTCCAGGCTGAGGAGAAGAC	0.323													0	0	0	1	0	8	11										A	156375436	G	A	156375436	4	1	68	1	0	0	0	0	0	1	0	0	15900	1299	45	1	321	1	TIMD4	5	156375436	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2103368	156375436	24539824	335	20855										
DOCK2	1794	broad.mit.edu	37	chr5	169469046	169469046	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagcagtgtgcatcacaggtCatgcagacaggccagcagca	13	11	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:169469046C>T	uc003maf.2	+	38	3866	c.3786C>T	c.(3784-3786)GTC>GTT	p.V1262V	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.V754V	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1262	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CATCACAGGTCATGCAGACAG	0.542													0	0	0	1	0	9	8										T	169469046	C	T	169469046	2	4	68	1	0	0	0	0	0	0	0	1	4687	813	29	1		1	DOCK2	5	169469046	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	13093610	169469046	11446214	336	20856										
CLTB	1212	broad.mit.edu	37	chr5	175843355	175843355	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgacgagaagaagccaaagtCatcagccattttccccgcgc	9	14	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr5:175843355C>T	uc003meh.2	-	2	185	c.10G>A	c.(10-12)GAC>AAC	p.D4N	CLTB_uc003mei.2_Missense_Mutation_p.D4N|CLTB_uc011dfn.1_RNA	NM_007097	NP_009028	P09497	CLCB_HUMAN	clathrin, light polypeptide isoform b	4					intracellular protein transport|vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle	protein binding|structural molecule activity				0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.098)		AAGCCAAAGTCATCAGCCATT	0.741													0	0	0	1	0	6	15										T	175843355	C	T	175843355	3	4	68	1	0	0	0	0	1	0	0	0	3565	826	29	1	703	1	CLTB	5	175843355	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6374309	175843355	5071905	337	20857										
IRF4	3662	broad.mit.edu	37	chr6	401636	401636	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggggcgtggtcctctggatgGcccccgacgggctctatgcg	17	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:401636G>C	uc003msz.3	+	7	1071	c.958G>C	c.(958-960)GCC>CCC	p.A320P	IRF4_uc010jne.1_Missense_Mutation_p.A320P|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.A319P|IRF4_uc003mtc.1_Missense_Mutation_p.A150P	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	320					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		CCTCTGGATGGCCCCCGACGG	0.612			T	IGH@	MM 								0	0	0	1	0	7	19										C	401636	G	C	401636	3	2	68	1	0	0	0	0	1	0	0	0	7832	1203	42	4	980	4	IRF4	6	401636	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		401636	170713431	338	20858										
FOXQ1	94234	broad.mit.edu	37	chr6	1313343	1313343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgccatggccatccgcgactCggcgggcgggcgcttgacgc	16	16	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:1313343C>T	uc003mtl.3	+	1	669	c.404C>T	c.(403-405)TCG>TTG	p.S135L		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	135	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		ATCCGCGACTCGGCGGGCGGG	0.592													0	0	0	1	0	10	20										T	1313343	C	T	1313343	3	4	68	1	0	0	0	0	1	0	0	0	6030	893	31	1	406	1	FOXQ1	6	1313343	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	911707	1313343	169801724	339	20859										
NRN1	51299	broad.mit.edu	37	chr6	5999356	5999356	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggtttttggattcttttctCagtttatcccacatatcttt	5	8	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:5999356C>T	uc003mwu.2	-	3	933	c.282G>A	c.(280-282)CTG>CTA	p.L94L	NRN1_uc003mwt.2_Silent_p.L120L	NM_016588	NP_057672	Q9NPD7	NRN1_HUMAN	neuritin precursor	94						anchored to membrane|plasma membrane					0	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		ATTCTTTTCTCAGTTTATCCC	0.562													0	0	0	1	0	6	43										T	5999356	C	T	5999356	2	4	68	1	0	0	0	0	0	0	0	1	10658	813	29	1		1	NRN1	6	5999356	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4686013	5999356	165115711	340	20860										
ATXN1	6310	broad.mit.edu	37	chr6	16327637	16327637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctttcttggtggcctcccgaGggacaaagtggctgccggag	15	11	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:16327637G>A	uc003nbt.2	-	8	1876	c.905C>T	c.(904-906)CCT>CTT	p.P302L	ATXN1_uc010jpi.2_Missense_Mutation_p.P302L|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	302					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGCCTCCCGAGGGACAAAGTG	0.657													0	0	0	1	0	8	48										A	16327637	G	A	16327637	3	1	68	1	0	0	0	0	1	0	0	0	1209	1000	35	2	1550	2	ATXN1	6	16327637	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10328281	16327637	154787430	341	20861										
NUP153	9972	broad.mit.edu	37	chr6	17626341	17626341	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagaagtggctggtgtacttGaactagaggaactgttgttc	13	6	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:17626341G>A	uc003ncd.1	-	19	3799	c.3599C>T	c.(3598-3600)TCA>TTA	p.S1200L	NUP153_uc011dje.1_Missense_Mutation_p.S1231L|NUP153_uc010jpl.1_Missense_Mutation_p.S1158L	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	1200					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TGGTGTACTTGAACTAGAGGA	0.418													0	0	0	1	0	20	29										A	17626341	G	A	17626341	3	1	68	1	0	0	0	0	1	0	0	0	10755	1294	45	1	844	1	NUP153	6	17626341	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1298704	17626341	153488726	342	20862										
KIF13A	63971	broad.mit.edu	37	chr6	17790135	17790135	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catatcatcaccatcctcatCatctctctggtaggaaaaaa	4	12	6	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:17790135C>G	uc003ncg.3	-	26	3334	c.3229G>C	c.(3229-3231)GAT>CAT	p.D1077H	KIF13A_uc003ncf.2_Intron|KIF13A_uc003nch.3_Missense_Mutation_p.D1077H|KIF13A_uc003nci.3_Intron	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1077					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CCATCCTCATCATCTCTCTGG	0.383													0	0	0	1	0	10	22										G	17790135	C	G	17790135	3	3	68	1	0	0	0	0	1	0	0	0	8274	826	29	1	2269	1	KIF13A	6	17790135	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	163794	17790135	153324932	343	20863										
KIF13A	63971	broad.mit.edu	37	chr6	17855761	17855761	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgactcattttgctccaaaGagatccttttaaataaagca	6	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:17855761G>C	uc003ncg.3	-	6	506	c.401C>G	c.(400-402)TCT>TGT	p.S134C	KIF13A_uc003ncf.2_Missense_Mutation_p.S134C|KIF13A_uc003nch.3_Missense_Mutation_p.S134C|KIF13A_uc003nci.3_Missense_Mutation_p.S134C	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	134	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTGCTCCAAAGAGATCCTTTT	0.423													0	0	0	1	0	14	43										C	17855761	G	C	17855761	3	2	68	1	0	0	0	0	1	0	0	0	8274	942	33	1	5177	1	KIF13A	6	17855761	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	65626	17855761	153259306	344	20864										
LRRC16A	55604	broad.mit.edu	37	chr6	25466165	25466165	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcacaaaactgtcctctaagGatctaaaactggtaagtaat	6	8	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:25466165G>A	uc011djw.1	+	9	1055	c.679G>A	c.(679-681)GAT>AAT	p.D227N	LRRC16A_uc010jpx.2_Missense_Mutation_p.D227N|LRRC16A_uc010jpy.2_Missense_Mutation_p.D227N|LRRC16A_uc003nez.1_Missense_Mutation_p.D66N	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	227					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GTCCTCTAAGGATCTAAAACT	0.363													0	0	0	1	0	17	91										A	25466165	G	A	25466165	3	1	68	1	0	0	0	0	1	0	0	0	8971	1174	41	1	713	1	LRRC16A	6	25466165	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7610404	25466165	145648902	345	20865										
SLC17A1	6568	broad.mit.edu	37	chr6	25811931	25811931	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctggtcaggaagaagtctGataactgacctgctaggtta	11	8	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:25811931G>C	uc003nfh.3	-	9	1081	c.965C>G	c.(964-966)TCA>TGA	p.S322*	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Nonsense_Mutation_p.S320*|SLC17A1_uc010jqc.1_Nonsense_Mutation_p.S266*	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	322					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						GAAGAAGTCTGATAACTGACC	0.448													0	0	0	1	0	22	65										C	25811931	G	C	25811931	4	2	68	1	0	0	0	0	0	1	0	0	14416	1294	45	1	454	1	SLC17A1	6	25811931	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	345766	25811931	145303136	346	20866										
BTN1A1	696	broad.mit.edu	37	chr6	26508758	26508758	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctggacccagacacagctCatccccacctctttctttat	4	17	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:26508758C>T	uc003nif.3	+	7	957	c.937C>T	c.(937-939)CAT>TAT	p.H313Y		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	313	B30.2/SPRY.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						AGACACAGCTCATCCCCACCT	0.463													0	0	0	1	0	98	191										T	26508758	C	T	26508758	3	4	68	1	0	0	0	0	1	0	0	0	1559	826	29	1	963	1	BTN1A1	6	26508758	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	696827	26508758	144606309	347	20867										
PGBD1	84547	broad.mit.edu	37	chr6	28264604	28264604	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctttttagacattggtgaaGactgaggaagaaacagccca	10	7	1	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:28264604G>C	uc003nky.2	+	5	1024	c.654G>C	c.(652-654)AAG>AAC	p.K218N	PGBD1_uc003nkz.2_Missense_Mutation_p.K218N	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	218					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CATTGGTGAAGACTGAGGAAG	0.463													0	0	0	1	0	13	79										C	28264604	G	C	28264604	3	2	68	1	0	0	0	0	1	0	0	0	11780	933	33	1	668	1	PGBD1	6	28264604	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1755846	28264604	142850463	348	20868										
PPP1R10	5514	broad.mit.edu	37	chr6	30576867	30576867	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacttacttgaccaatatttCtggtgaacgggtctgcagga	10	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:30576867C>T	uc003nqn.1	-	4	733	c.181G>A	c.(181-183)GAA>AAA	p.E61K	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	61	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						ACCAATATTTCTGGTGAACGG	0.483													0	0	0	1	0	14	56										T	30576867	C	T	30576867	3	4	68	1	0	0	0	0	1	0	0	0	12352	922	32	1	2709	1	PPP1R10	6	30576867	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2312263	30576867	140538200	349	20869										
DHX16	8449	broad.mit.edu	37	chr6	30627868	30627868	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gattcgaaacacaggggcgtCatcaaagaaggtggaaaaac	12	7	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:30627868C>T	uc003nqz.2	-	10	1908	c.1696G>A	c.(1696-1698)GAC>AAC	p.D566N	DHX16_uc003nqy.2_Missense_Mutation_p.D85N|DHX16_uc011dmo.1_Missense_Mutation_p.D506N	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	566	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						ACAGGGGCGTCATCAAAGAAG	0.542													0	0	0	1	0	20	69										T	30627868	C	T	30627868	3	4	68	1	0	0	0	0	1	0	0	0	4502	826	29	1	1473	1	DHX16	6	30627868	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	51001	30627868	140487199	350	20870										
BAT2	7916	broad.mit.edu	37	chr6	31594883	31594883	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagaaacctctcggcctccaGagacagagccgggacctcct	10	16	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:31594883G>A	uc003nvb.3	+	11	1447	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.E400K	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	400	4 X 57 AA type A repeats.|2 X type B repeats.|2-1.					cytoplasm|nucleus	protein binding				0						TCGGCCTCCAGAGACAGAGCC	0.672													0	0	0	1	0	11	44										A	31594883	G	A	31594883	3	1	68	1	0	0	0	0	1	0	0	0	1319	943	33	1	1236	1	BAT2	6	31594883	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	967015	31594883	139520184	351	20871										
TNXB	7148	broad.mit.edu	37	chr6	32036422	32036422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacggtcagctcccccaggcGaggcttgatggggggctcgg	17	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:32036422G>A	uc003nzl.2	-	17	6167	c.5965C>T	c.(5965-5967)CGC>TGC	p.R1989C		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2071	Fibronectin type-III 13.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCCCCCAGGCGAGGCTTGATG	0.622													0	0	0	1	0	16	51										A	32036422	G	A	32036422	3	1	68	1	0	0	0	0	1	0	0	0	16343	1058	37	1	8860	1	TNXB	6	32036422	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	441539	32036422	139078645	352	20872										
ATF6B	1388	broad.mit.edu	37	chr6	32094926	32094926	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcgatgactcggagctgaggGaggaggaagagcagggggaa	21	5	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:32094926G>A	uc003nzn.2	-	4	329	c.296C>T	c.(295-297)TCC>TTC	p.S99F	ATF6B_uc003nzo.2_Missense_Mutation_p.S96F|ATF6B_uc011dpg.1_Missense_Mutation_p.S33F|ATF6B_uc011dph.1_Missense_Mutation_p.S99F	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	99	Cytoplasmic (Potential).|Poly-Ser.				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGAGCTGAGGGAGGAGGAAGA	0.527													0	0	0	1	0	6	17										A	32094926	G	A	32094926	3	1	68	1	0	0	0	0	1	0	0	0	1085	1174	41	1	1875	1	ATF6B	6	32094926	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	58504	32094926	139020141	353	20873										
PBX2	5089	broad.mit.edu	37	chr6	32154464	32154464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catcgagtgtcggagtgattCcacctgcaggcagcagagga	14	10	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:32154464C>T	uc003oav.1	-	8	1388	c.1117G>A	c.(1117-1119)GAA>AAA	p.E373K	AGER_uc003oar.2_5'Flank|AGER_uc011dpm.1_5'Flank|AGER_uc011dpn.1_5'Flank|AGER_uc003oal.1_5'Flank|AGER_uc010jtv.1_5'Flank|AGER_uc011dpo.1_5'Flank|AGER_uc003oam.1_5'Flank|AGER_uc003oan.1_5'Flank|AGER_uc003oap.1_5'Flank|AGER_uc003oat.1_5'Flank|AGER_uc003oao.1_5'Flank|AGER_uc003oaq.1_5'Flank|AGER_uc010jtw.1_5'Flank|AGER_uc003oas.1_5'Flank|AGER_uc003oau.1_5'Flank|AGER_uc011dpp.1_5'Flank|AGER_uc011dpq.1_5'Flank|AGER_uc011dpr.1_5'Flank|AGER_uc011dps.1_5'Flank	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	373							transcription factor binding			ovary(1)	1						CGGAGTGATTCCACCTGCAGG	0.552													0	0	0	1	0	15	38										T	32154464	C	T	32154464	3	4	68	1	0	0	0	0	1	0	0	0	11493	864	30	1	183	1	PBX2	6	32154464	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	59538	32154464	138960603	354	20874										
SYNGAP1	8831	broad.mit.edu	37	chr6	33411122	33411122	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctccttccagaaccctctCttccacatggctgctgatgg	7	16	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:33411122C>T	uc011dri.1	+	15	2988	c.2793C>T	c.(2791-2793)CTC>CTT	p.L931L	SYNGAP1_uc010juy.2_Silent_p.L902L|SYNGAP1_uc010juz.2_Silent_p.L643L	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	931					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						AGAACCCTCTCTTCCACATGG	0.582													0	0	0	1	0	37	210										T	33411122	C	T	33411122	2	4	68	1	0	0	0	0	0	0	0	1	15444	900	32	1		1	SYNGAP1	6	33411122	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1256658	33411122	137703945	355	20875										
FTSJD2	23070	broad.mit.edu	37	chr6	37443108	37443108	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccttctaggggaaggcccaGaggaagatcagtgccatcca	12	11	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:37443108G>C	uc003ons.2	+	19	2209	c.1956G>C	c.(1954-1956)CAG>CAC	p.Q652H		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	652					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GGAAGGCCCAGAGGAAGATCA	0.592													0	0	0	1	0	6	24										C	37443108	G	C	37443108	3	2	68	1	0	0	0	0	1	0	0	0	6091	933	33	1	2026	1	FTSJD2	6	37443108	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4031986	37443108	133671959	356	20876										
TAF8	129685	broad.mit.edu	37	chr6	42019184	42019184	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggttgtgagctccttgctGacagaggcagggtttgagag	17	6	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:42019184G>A	uc003ors.2	+	2	164	c.135G>A	c.(133-135)CTG>CTA	p.L45L	CCND3_uc003orp.2_5'Flank|CCND3_uc011duk.1_5'Flank|CCND3_uc011dum.1_5'Flank|TAF8_uc003orr.2_Silent_p.L45L|TAF8_uc003ort.2_Silent_p.L45L|TAF8_uc003oru.1_Silent_p.L45L|TAF8_uc003orv.1_Silent_p.L45L|TAF8_uc011dun.1_5'UTR	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	45	Histone-fold.				cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			GCTCCTTGCTGACAGAGGCAG	0.532													0	0	0	1	0	24	99										A	42019184	G	A	42019184	2	1	68	1	0	0	0	0	0	0	0	1	15531	1277	45	1		1	TAF8	6	42019184	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4576076	42019184	129095883	357	20877										
SLC35B2	347734	broad.mit.edu	37	chr6	44222852	44222856	+	Frame_Shift_Del	DEL	ATCTT	ATCTT	-													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acatcatctgcaccgatgacAtcttataggcaaacagggca							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:44222852_44222856delATCTT	uc003oxd.2	-	4	1022_1026	c.886_890delAAGAT	c.(886-891)AAGATGfs	p.K296fs	SLC35B2_uc011dvt.1_Frame_Shift_Del_p.K199fs|SLC35B2_uc011dvu.1_Frame_Shift_Del_p.K163fs	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	296_297					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CACCGATGACATCTTATAGGCAAAC	0.532																		7	55	---	---								-	44222856	ATCTT	-	44222852	7	5	68	1	0	1	0	1	0	0	0	0	14576	217	8	0	412	0	SLC35B2	6	44222852	Frame_Shift_Del	DEL	ATCTT	TCGA-DK-A3X1-01A-12D-A22Z-08	2203668	44222852	126892215	358	20878										
CDC5L	988	broad.mit.edu	37	chr6	44374146	44374146	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accatcagctattcttcaaaCtagtggtgtttctgaattta	6	8	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:44374146C>T	uc003oxl.2	+	7	1104	c.845C>T	c.(844-846)ACT>ATT	p.T282I		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	282	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATTCTTCAAACTAGTGGTGTT	0.318													0	0	0	1	0	29	122										T	44374146	C	T	44374146	3	4	68	1	0	0	0	0	1	0	0	0	3082	565	20	2	871	2	CDC5L	6	44374146	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	151294	44374146	126740921	359	20879										
TNFRSF21	27242	broad.mit.edu	37	chr6	47221041	47221041	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttctccacaacatcgtttCtccggtgctggcgcagggcg	11	14	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:47221041C>G	uc003oyv.2	-	4	1893	c.1460G>C	c.(1459-1461)AGA>ACA	p.R487T		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	487	Cytoplasmic (Potential).|Death.				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			AACATCGTTTCTCCGGTGCTG	0.617													0	0	0	1	0	4	18										G	47221041	C	G	47221041	3	3	68	1	0	0	0	0	1	0	0	0	16292	913	32	1	519	1	TNFRSF21	6	47221041	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2846895	47221041	123894026	360	20880										
C6orf138	442213	broad.mit.edu	37	chr6	47846150	47846150	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggtgctttttggaagggggGaaaaacgttaggaacacagg	16	4	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:47846150G>T	uc011dwm.1	-	3	2464	c.2379C>A	c.(2377-2379)TTC>TTA	p.F793L	C6orf138_uc011dwn.1_Missense_Mutation_p.F557L	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	810						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TGGAAGGGGGGAAAAACGTTA	0.448													1	0	3.99206e-14	1	4.52745e-14	19	74										T	47846150	G	T	47846150	3	4	68	1	0	0	0	0	1	0	0	0	2332	1165	41	3	114	3	C6orf138	6	47846150	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	625109	47846150	123268917	361	20881										
IL17A	3605	broad.mit.edu	37	chr6	52052468	52052468	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacaatcccacgaaatccagGatgcccaaattctgaggaca	7	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:52052468G>A	uc003pak.1	+	2	140	c.95G>A	c.(94-96)GGA>GAA	p.G32E		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	32					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					CGAAATCCAGGATGCCCAAAT	0.493													0	0	0	1	0	95	146										A	52052468	G	A	52052468	3	1	68	1	0	0	0	0	1	0	0	0	7634	1174	41	1	101	1	IL17A	6	52052468	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4206318	52052468	119062599	362	20882										
LRRC1	55227	broad.mit.edu	37	chr6	53761655	53761655	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccagctgcgaagactagaaGaacttgatttaggaaacaat	9	8	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:53761655G>A	uc003pcd.1	+	6	809	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	178	LRR 8.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		AAGACTAGAAGAACTTGATTT	0.313													0	0	0	1	0	14	44										A	53761655	G	A	53761655	3	1	68	1	0	0	0	0	1	0	0	0	8966	943	33	1	554	1	LRRC1	6	53761655	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1709187	53761655	117353412	363	20883										
HCRTR2	3062	broad.mit.edu	37	chr6	55142257	55142257	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcctcgagggccaggacagcCaacgaagtcccggatgagcg	15	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:55142257C>T	uc003pcl.2	+	5	1157	c.842C>T	c.(841-843)CCA>CTA	p.P281L	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	281	Cytoplasmic (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CCAGGACAGCCAACGAAGTCC	0.517													0	0	0	1	0	9	37										T	55142257	C	T	55142257	3	4	68	1	0	0	0	0	1	0	0	0	7002	594	21	2	860	2	HCRTR2	6	55142257	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1380602	55142257	115972810	364	20884										
DST	667	broad.mit.edu	37	chr6	56458793	56458793	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttttctaattcttcctgcaGagagtgagttaacttcattt	6	8	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:56458793G>A	uc003pdf.2	-	42	6065	c.6037C>T	c.(6037-6039)CTG>TTG	p.L2013L	DST_uc003pcz.3_Silent_p.L1835L|DST_uc011dxj.1_Silent_p.L1864L|DST_uc011dxk.1_Silent_p.L1875L|DST_uc003pcy.3_Silent_p.L1509L|DST_uc010kaa.1_RNA	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3921					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTTCCTGCAGAGAGTGAGTT	0.413													0	0	0	1	0	9	51										A	56458793	G	A	56458793	2	1	68	1	0	0	0	0	0	0	0	1	4783	933	33	1		1	DST	6	56458793	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1316536	56458793	114656274	365	20885										
PRIM2	5558	broad.mit.edu	37	chr6	57512639	57512640	+	Frame_Shift_Del	DEL	TT	TT	-													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcatcatctgctctggcctcTttaaattcctctctggaaat							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:57512639_57512640delTT	uc003pdx.2	+	15	1554_1555	c.1467_1468delTT	c.(1465-1470)TCTTTAfs	p.S489fs		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	489_490					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CTCTGGCCTCTTTAAATTCCTC	0.411																		30	496	---	---								-	57512640	TT	-	57512639	7	5	68	1	0	1	0	1	0	0	0	0	12491	1596	56	0	1517	0	PRIM2	6	57512639	Frame_Shift_Del	DEL	TT	TCGA-DK-A3X1-01A-12D-A22Z-08	1053846	57512639	113602428	366	20886										
KHDRBS2	202559	broad.mit.edu	37	chr6	62390905	62390905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtgttccctgtatccccctCtggctgacctttgcggtggt	12	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:62390905C>G	uc003peg.2	-	9	1260	c.1013G>C	c.(1012-1014)AGA>ACA	p.R338T		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		GTATCCCCCTCTGGCTGACCT	0.493													0	0	0	1	0	6	35										G	62390905	C	G	62390905	3	3	68	1	0	0	0	0	1	0	0	0	8147	913	32	1	40	1	KHDRBS2	6	62390905	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4878266	62390905	108724162	367	20887										
CD109	135228	broad.mit.edu	37	chr6	74490221	74490221	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aattcttttgcagtctttcaGgtatgttttgcttgctatat	7	6	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:74490221G>C	uc003php.2	+	16	2327	c.1902G>C	c.(1900-1902)CAG>CAC	p.Q634H	CD109_uc010kaz.2_Missense_Mutation_p.Q634H|CD109_uc003phq.2_Missense_Mutation_p.Q634H|CD109_uc010kba.2_Missense_Mutation_p.Q557H	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	634	Bait region (approximate) (By similarity).					anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						CAGTCTTTCAGGTATGTTTTG	0.294													0	0	0	1	0	14	102										C	74490221	G	C	74490221	3	2	68	1	0	0	0	0	1	0	0	0	2963	1014	35	4	1964	4	CD109	6	74490221	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	12099316	74490221	96624846	368	20888										
SENP6	26054	broad.mit.edu	37	chr6	76412689	76412689	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atactgcgagtgaaaatgaaGaattcaataaaggagaatct	9	4	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:76412689G>C	uc003pid.3	+	19	3236	c.2617G>C	c.(2617-2619)GAA>CAA	p.E873Q	SENP6_uc003pie.3_Missense_Mutation_p.E866Q|SENP6_uc010kbf.2_Intron	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	873	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				TGAAAATGAAGAATTCAATAA	0.368													0	0	0	1	0	46	153										C	76412689	G	C	76412689	3	2	68	1	0	0	0	0	1	0	0	0	14050	943	33	1	2691	1	SENP6	6	76412689	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1922468	76412689	94702378	369	20889										
DOPEY1	23033	broad.mit.edu	37	chr6	83839159	83839159	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagctcttcctagagtgctCaagtttcccagtttacattg	7	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:83839159C>G	uc003pjs.1	+	16	2533	c.2273C>G	c.(2272-2274)TCA>TGA	p.S758*	DOPEY1_uc011dyy.1_Nonsense_Mutation_p.S749*|DOPEY1_uc010kbl.1_Nonsense_Mutation_p.S749*	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	758					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTAGAGTGCTCAAGTTTCCCA	0.393													0	0	0	1	0	35	57										G	83839159	C	G	83839159	4	3	68	1	0	0	0	0	0	1	0	0	4707	838	29	1	2327	1	DOPEY1	6	83839159	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7426470	83839159	87275908	370	20890										
UBE2J1	51465	broad.mit.edu	37	chr6	90052151	90052151	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctgggggccctctaaccgtGaagtgccattcaaaaaggtt	11	10	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:90052151G>T	uc010kcb.2	-	4	302	c.129C>A	c.(127-129)TTC>TTA	p.F43L	UBE2J1_uc003pnc.2_Missense_Mutation_p.F43L	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	43	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CTCTAACCGTGAAGTGCCATT	0.378													1	0	5.50884e-06	1	5.79878e-06	12	39										T	90052151	G	T	90052151	3	4	68	1	0	0	0	0	1	0	0	0	16857	1281	45	3	851	3	UBE2J1	6	90052151	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6212992	90052151	81062916	371	20891										
KLHL32	114792	broad.mit.edu	37	chr6	97489422	97489422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgatgaggttaatttgcacGgtgtgaccagccttggctta	12	8	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:97489422G>A	uc010kcm.1	+	4	731	c.259G>A	c.(259-261)GGT>AGT	p.G87S	KLHL32_uc003poy.2_Missense_Mutation_p.G87S|KLHL32_uc011ead.1_Intron|KLHL32_uc003poz.2_5'UTR|KLHL32_uc011eae.1_Intron|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	87	BTB.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TAATTTGCACGGTGTGACCAG	0.428													0	0	0	1	0	10	91										A	97489422	G	A	97489422	3	1	68	1	0	0	0	0	1	0	0	0	8386	1116	39	2	269	2	KLHL32	6	97489422	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7437271	97489422	73625645	372	20892										
GRIK2	2898	broad.mit.edu	37	chr6	102503216	102503216	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctttcttaggttctccatatCgagacaaaattaccatagca	5	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:102503216C>G	uc003pqp.3	+	15	2572	c.2323C>G	c.(2323-2325)CGA>GGA	p.R775G	GRIK2_uc003pqo.3_Missense_Mutation_p.R775G|GRIK2_uc010kcw.2_Missense_Mutation_p.R775G	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	775	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TTCTCCATATCGAGACAAAAT	0.408													0	0	0	1	0	15	56										G	102503216	C	G	102503216	3	3	68	1	0	0	0	0	1	0	0	0	6774	876	31	1	2381	1	GRIK2	6	102503216	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5013794	102503216	68611851	373	20893										
MICAL1	64780	broad.mit.edu	37	chr6	109769984	109769984	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcacacagagctagcccatCagcccaggaggaagacaaat	11	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:109769984C>A	uc003ptj.2	-	11	1869	c.1615G>T	c.(1615-1617)GAT>TAT	p.D539Y	MICAL1_uc003ptk.2_Missense_Mutation_p.D539Y|MICAL1_uc010kdr.2_Missense_Mutation_p.D453Y|MICAL1_uc011eaq.1_Missense_Mutation_p.D558Y	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	539	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		GCTAGCCCATCAGCCCAGGAG	0.622													1	0	8.53417e-09	1	9.31001e-09	35	140										A	109769984	C	A	109769984	3	1	68	1	0	0	0	0	1	0	0	0	9569	826	29	3	1644	3	MICAL1	6	109769984	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7266768	109769984	61345083	374	20894										
ECT2L	345930	broad.mit.edu	37	chr6	139183796	139183796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagttctttcccagctgtctCaactaactggcacgttcttt	6	12	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:139183796C>G	uc003qif.1	+	9	1334	c.1231C>G	c.(1231-1233)CAA>GAA	p.Q411E	ECT2L_uc011edq.1_Missense_Mutation_p.Q342E	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	411					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CCAGCTGTCTCAACTAACTGG	0.438													0	0	0	1	0	9	65										G	139183796	C	G	139183796	3	3	68	1	0	0	0	0	1	0	0	0	4902	827	29	1	1265	1	ECT2L	6	139183796	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	29413812	139183796	31931271	375	20895										
SASH1	23328	broad.mit.edu	37	chr6	148848652	148848652	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctactgcctctcgcatctctCttgggaaaaaggtgaaatca	8	11	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:148848652C>G	uc003qme.1	+	12	1823	c.1348C>G	c.(1348-1350)CTT>GTT	p.L450V	SASH1_uc011eeb.1_Missense_Mutation_p.L211V|SASH1_uc003qmf.1_5'UTR	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	450							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TCGCATCTCTCTTGGGAAAAA	0.418													0	0	0	1	0	21	73										G	148848652	C	G	148848652	3	3	68	1	0	0	0	0	1	0	0	0	13848	913	32	1	1394	1	SASH1	6	148848652	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9664856	148848652	22266415	376	20896										
MTHFD1L	25902	broad.mit.edu	37	chr6	151270192	151270192	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggaataaataagactgatcCgagcacactgacagaagagg	12	7	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:151270192C>T	uc003qob.2	+	16	1917	c.1649C>T	c.(1648-1650)CCG>CTG	p.P550L	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.P551L|MTHFD1L_uc003qoc.2_Missense_Mutation_p.P498L	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	550	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		AAGACTGATCCGAGCACACTG	0.453													0	0	0	1	0	15	17										T	151270192	C	T	151270192	3	4	68	1	0	0	0	0	1	0	0	0	9928	652	23	2	1711	2	MTHFD1L	6	151270192	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2421540	151270192	19844875	377	20897										
SYNE1	23345	broad.mit.edu	37	chr6	152642938	152642938	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctgaacccaacatttcacaGaattgatctgagtctccacc	5	14	3	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:152642938G>A	uc010kiw.2	-	83	16603	c.16001C>T	c.(16000-16002)TCT>TTT	p.S5334F	SYNE1_uc003qot.3_Missense_Mutation_p.S5263F|SYNE1_uc003qou.3_Missense_Mutation_p.S5334F|SYNE1_uc010kiz.2_Missense_Mutation_p.S1089F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5334	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACATTTCACAGAATTGATCTG	0.398										HNSCC(10;0.0054)			0	0	0	1	0	24	77										A	152642938	G	A	152642938	3	1	68	1	0	0	0	0	1	0	0	0	15442	942	33	1	10721	1	SYNE1	6	152642938	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1372746	152642938	18472129	378	20898										
SYNE1	23345	broad.mit.edu	37	chr6	152719867	152719867	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttggaattcctgcatagactCttttgaaagaaaaaataaat	6	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:152719867C>G	uc010kiw.2	-	49	7840	c.7238_splice	c.e49-1	p.E2413_splice	SYNE1_uc003qot.3_Splice_Site_p.E2420_splice|SYNE1_uc003qou.3_Splice_Site_p.E2413_splice|SYNE1_uc010kjb.1_Splice_Site_p.E2396_splice	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCATAGACTCTTTTGAAAGa	0.368										HNSCC(10;0.0054)			0	0	0	1	0	17	54										G	152719867	C	G	152719867	5	3	68	1	0	0	0	0	0	0	1	0	15442	927	32	1	19621	1	SYNE1	6	152719867	Splice_Site	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	76929	152719867	18395200	379	20899										
ARID1B	57492	broad.mit.edu	37	chr6	157528459	157528459	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggatggtgtgcccgtctgcaGaggcacaagatccctttcca	12	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:157528459G>T	uc003qqn.2	+	20	6282	c.6130G>T	c.(6130-6132)GAG>TAG	p.E2044*	ARID1B_uc003qqo.2_Nonsense_Mutation_p.E2004*|ARID1B_uc003qqp.2_Nonsense_Mutation_p.E1991*	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2049					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CCCGTCTGCAGAGGCACAAGA	0.532													1	0	8.69298e-16	1	9.90339e-16	42	110										T	157528459	G	T	157528459	4	4	68	1	0	0	0	0	0	1	0	0	914	943	33	3	6262	3	ARID1B	6	157528459	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4808592	157528459	13586608	380	20900										
IGF2R	3482	broad.mit.edu	37	chr6	160525708	160525708	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgttgatccctggcaggtGaataaggaagaagagacaga	14	6	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:160525708G>A	uc003qta.2	+	48	7216	c.7068G>A	c.(7066-7068)GTG>GTA	p.V2356V		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2356	Cytoplasmic (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CCTGGCAGGTGAATAAGGAAG	0.567													0	0	0	1	0	8	36										A	160525708	G	A	160525708	2	1	68	1	0	0	0	0	0	0	0	1	7576	1277	45	1		1	IGF2R	6	160525708	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2997249	160525708	10589359	381	20901										
RPS6KA2	6196	broad.mit.edu	37	chr6	166864689	166864689	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaatcctctaaacaggtgatGagcgtttgcactcgggggga	14	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:166864689G>A	uc003qvb.1	-	13	1327	c.1108C>T	c.(1108-1110)CAT>TAT	p.H370Y	RPS6KA2_uc011ego.1_Missense_Mutation_p.H281Y|RPS6KA2_uc010kkl.1_Missense_Mutation_p.H281Y|RPS6KA2_uc003qvc.1_Missense_Mutation_p.H378Y|RPS6KA2_uc003qvd.1_Missense_Mutation_p.H395Y	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	370	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		AACAGGTGATGAGCGTTTGCA	0.547													0	0	0	1	0	21	39										A	166864689	G	A	166864689	3	1	68	1	0	0	0	0	1	0	0	0	13651	1290	45	1	1129	1	RPS6KA2	6	166864689	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6338981	166864689	4250378	382	20902										
RPS6KA2	6196	broad.mit.edu	37	chr6	166864716	166864716	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcactcggggggacgccagGagagtctgtaggtgacaggg	19	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr6:166864716G>T	uc003qvb.1	-	13	1300	c.1081C>A	c.(1081-1083)CCT>ACT	p.P361T	RPS6KA2_uc011ego.1_Missense_Mutation_p.P272T|RPS6KA2_uc010kkl.1_Missense_Mutation_p.P272T|RPS6KA2_uc003qvc.1_Missense_Mutation_p.P369T|RPS6KA2_uc003qvd.1_Missense_Mutation_p.P386T	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	361	AGC-kinase C-terminal.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		GGGACGCCAGGAGAGTCTGTA	0.473													1	0	3.32936e-07	1	3.55508e-07	17	40										T	166864716	G	T	166864716	3	4	68	1	0	0	0	0	1	0	0	0	13651	1174	41	3	1156	3	RPS6KA2	6	166864716	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	27	166864716	4250351	383	20903										
TTYH3	80727	broad.mit.edu	37	chr7	2686589	2686589	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgccggcggcgcaagagcGaggagcacctggacgccgac	17	14	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:2686589G>A	uc003smp.2	+	2	413	c.226G>A	c.(226-228)GAG>AAG	p.E76K	TTYH3_uc010ksn.2_5'Flank|TTYH3_uc003smq.2_5'Flank	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	76	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		GCGCAAGAGCGAGGAGCACCT	0.582													0	0	0	1	0	4	10										A	2686589	G	A	2686589	3	1	68	1	0	0	0	0	1	0	0	0	16738	1059	37	1	232	1	TTYH3	7	2686589	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		2686589	156452074	384	20904										
RBAK	57786	broad.mit.edu	37	chr7	5105215	5105215	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggaaatatgaacgtacttGatgtggaaaatctctgaagt	11	4	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:5105215G>C	uc010kss.1	+	6	2452	c.2128G>C	c.(2128-2130)GAT>CAT	p.D710H	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Missense_Mutation_p.D710H	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	710	Interaction with AR.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GAACGTACTTGATGTGGAAAA	0.368													0	0	0	1	0	15	86										C	5105215	G	C	5105215	3	2	68	1	0	0	0	0	1	0	0	0	13100	1290	45	1	2142	1	RBAK	7	5105215	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2418626	5105215	154033448	385	20905										
TNRC18	84629	broad.mit.edu	37	chr7	5352267	5352267	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggggaggtggacgccctctCtcttcttgggtcggctcttg	15	11	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:5352267C>G	uc003soi.3	-	27	8604	c.8255G>C	c.(8254-8256)AGA>ACA	p.R2752T		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2752							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GACGCCCTCTCTCTTCTTGGG	0.716													0	0	0	1	0	14	67										G	5352267	C	G	5352267	3	3	68	1	0	0	0	0	1	0	0	0	16336	913	32	1	667	1	TNRC18	7	5352267	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	247052	5352267	153786396	386	20906										
FBXL18	80028	broad.mit.edu	37	chr7	5540603	5540603	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggctgggcgggcgcgcggtCggcgcgcggcgcggagtcag	23	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:5540603C>T	uc003soo.2	-	3	1391	c.1297G>A	c.(1297-1299)GAC>AAC	p.D433N	FBXL18_uc003son.3_Missense_Mutation_p.D433N	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	433										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		ggcgcgcggtcggcgcgcggc	0.562													0	0	0	1	0	5	11										T	5540603	C	T	5540603	3	4	68	1	0	0	0	0	1	0	0	0	5714	884	31	1	871	1	FBXL18	7	5540603	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	188336	5540603	153598060	387	20907										
AGR2	10551	broad.mit.edu	37	chr7	16841376	16841376	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctctggccagagtgtaggaGagggccacaaggagcaagaa	15	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:16841376G>C	uc003str.2	-	2	232	c.45C>G	c.(43-45)CTC>CTG	p.L15L	AGR2_uc011jxy.1_Silent_p.L15L	NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	15					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		GAGTGTAGGAGAGGGCCACAA	0.478													0	0	0	1	0	14	80										C	16841376	G	C	16841376	2	2	68	1	0	0	0	0	0	0	0	1	395	929	33	1		1	AGR2	7	16841376	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11300773	16841376	142297287	388	20908										
AHR	196	broad.mit.edu	37	chr7	17373647	17373647	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgcgatagctactccacttCagccaccatccatacttgaa	5	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:17373647C>A	uc011jxz.1	+	7	1430	c.817C>A	c.(817-819)CAG>AAG	p.Q273K	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	273					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TACTCCACTTCAGCCACCATC	0.403													1	0	3.76869e-24	1	4.34849e-24	20	94										A	17373647	C	A	17373647	3	1	68	1	0	0	0	0	1	0	0	0	416	827	29	3	843	3	AHR	7	17373647	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	532271	17373647	141765016	389	20909										
HDAC9	9734	broad.mit.edu	37	chr7	18801875	18801875	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accaaccccctggacggacaGaagctggaccccaggatact	10	15	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:18801875G>T	uc003suh.2	+	14	2171	c.2130G>T	c.(2128-2130)CAG>CAT	p.Q710H	HDAC9_uc003sue.2_Missense_Mutation_p.Q710H|HDAC9_uc011jyd.1_Missense_Mutation_p.Q710H|HDAC9_uc003sui.2_Missense_Mutation_p.Q713H|HDAC9_uc003suj.2_Missense_Mutation_p.Q669H|HDAC9_uc003sua.1_Missense_Mutation_p.Q688H	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	710	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGACGGACAGAAGCTGGACC	0.512													1	0	5.9392e-07	1	6.33113e-07	5	30										T	18801875	G	T	18801875	3	4	68	1	0	0	0	0	1	0	0	0	7014	933	33	3	2244	3	HDAC9	7	18801875	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1428228	18801875	140336788	390	20910										
OSBPL3	26031	broad.mit.edu	37	chr7	24849449	24849449	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctccatacacaggcagaaGaggagccgccgccacagtag	11	14	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:24849449G>A	uc003sxf.2	-	20	2699	c.2294C>T	c.(2293-2295)TCT>TTT	p.S765F	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.S729F|OSBPL3_uc003sxh.2_Missense_Mutation_p.S734F|OSBPL3_uc003sxi.2_Missense_Mutation_p.S698F	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	765					lipid transport		lipid binding|protein binding			skin(1)	1						ACAGGCAGAAGAGGAGCCGCC	0.547													0	0	0	1	0	29	55										A	24849449	G	A	24849449	3	1	68	1	0	0	0	0	1	0	0	0	11279	942	33	1	385	1	OSBPL3	7	24849449	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6047574	24849449	134289214	391	20911										
SNX10	29887	broad.mit.edu	37	chr7	26412157	26412157	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgatgacagcagttcacatGgatgtaaagtaaatacagct	10	6	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:26412157G>A	uc003sxx.2	+	7	786	c.571G>A	c.(571-573)GGA>AGA	p.G191R	SNX10_uc011jzg.1_Missense_Mutation_p.G214R|SNX10_uc010kuu.2_Missense_Mutation_p.G191R|SNX10_uc010kuv.2_Missense_Mutation_p.G187R|SNX10_uc010kuw.2_Missense_Mutation_p.G107R	NM_013322	NP_037454	Q9Y5X0	SNX10_HUMAN	sorting nexin 10	191					cell communication|endosome organization|protein transport	extrinsic to endosome membrane	1-phosphatidylinositol binding				0						CAGTTCACATGGATGTAAAGT	0.373													0	0	0	1	0	25	162										A	26412157	G	A	26412157	3	1	68	1	0	0	0	0	1	0	0	0	14881	1349	47	2	593	2	SNX10	7	26412157	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1562708	26412157	132726506	392	20912										
EVX1	2128	broad.mit.edu	37	chr7	27284678	27284678	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgtgcagggtccggctccGaggcgctggtcggcagtccg	18	13	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:27284678G>A	uc003szd.1	+	2	925	c.439G>A	c.(439-441)GAG>AAG	p.E147K	EVX1_uc011jzn.1_5'UTR|EVX1_uc010kuy.1_Silent_p.P128P	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	147						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GTCCGGCTCCGAGGCGCTGGT	0.672													0	0	0	1	0	19	64										A	27284678	G	A	27284678	3	1	68	1	0	0	0	0	1	0	0	0	5294	1059	37	1	445	1	EVX1	7	27284678	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	872521	27284678	131853985	393	20913										
TAX1BP1	8887	broad.mit.edu	37	chr7	27831832	27831832	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcagaacttaaactaaatGctatgaaaaaagatcaggta	8	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:27831832G>A	uc003szl.2	+	9	1404	c.1246G>A	c.(1246-1248)GCT>ACT	p.A416T	TAX1BP1_uc011jzo.1_Missense_Mutation_p.A416T|TAX1BP1_uc003szk.2_Missense_Mutation_p.A416T|TAX1BP1_uc011jzp.1_Missense_Mutation_p.A259T	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	416	Oligomerization.|Potential.				anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			TAAACTAAATGCTATGAAAAA	0.353													0	0	0	1	0	7	24										A	27831832	G	A	27831832	3	1	68	1	0	0	0	0	1	0	0	0	15591	1319	46	2	1276	2	TAX1BP1	7	27831832	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	547154	27831832	131306831	394	20914										
PLEKHA8	84725	broad.mit.edu	37	chr7	30087570	30087570	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caactggtgtgtccaattctGaggtaaaatattatttatta	7	5	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:30087570G>A	uc003tam.1	+	4	527	c.436G>A	c.(436-438)GAG>AAG	p.E146K	PLEKHA8_uc003tao.2_Missense_Mutation_p.E30K|PLEKHA8_uc003tap.1_Missense_Mutation_p.E146K|PLEKHA8_uc003tan.2_Missense_Mutation_p.E146K	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	146					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						GTCCAATTCTGAGGtaaaata	0.274													0	0	0	1	0	14	40										A	30087570	G	A	30087570	3	1	68	1	0	0	0	0	1	0	0	0	12062	1291	45	1	450	1	PLEKHA8	7	30087570	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2255738	30087570	129051093	395	20915										
NT5C3	51251	broad.mit.edu	37	chr7	33057059	33057059	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgatattcttacagtttcatCaaaatccataaaattggaca	4	7	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:33057059C>T	uc003tdk.2	-	7	777	c.700G>A	c.(700-702)GAT>AAT	p.D234N	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.D195N|NT5C3_uc003tdj.2_Missense_Mutation_p.D195N	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	234					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			ACAGTTTCATCAAAATCCATA	0.254													0	0	0	1	0	13	50										T	33057059	C	T	33057059	3	4	68	1	0	0	0	0	1	0	0	0	10688	826	29	1	322	1	NT5C3	7	33057059	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2969489	33057059	126081604	396	20916										
POLM	27434	broad.mit.edu	37	chr7	44119254	44119254	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acagggctgggaagggccttGagcaccgaggctgctctgca	16	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:44119254G>C	uc003tjt.2	-	4	650	c.558C>G	c.(556-558)CTC>CTG	p.L186L	POLM_uc003tju.2_Silent_p.L186L|POLM_uc003tjx.2_Silent_p.L186L|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_Intron|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Silent_p.L186L|POLM_uc011kbu.1_Silent_p.L153L|POLM_uc010kxy.2_Silent_p.L186L	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	186					DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						GAAGGGCCTTGAGCACCGAGG	0.627								DNA_polymerases_(catalytic_subunits)					0	0	0	1	0	14	79										C	44119254	G	C	44119254	2	2	68	1	0	0	0	0	0	0	0	1	12206	1277	45	1		1	POLM	7	44119254	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11062195	44119254	115019409	397	20917										
NPC1L1	29881	broad.mit.edu	37	chr7	44561680	44561680	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aactctgtggcatactggatCttctgggtgaaggagaagtt	13	6	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:44561680C>T	uc003tlb.2	-	11	2855	c.2799G>A	c.(2797-2799)AAG>AAA	p.K933K	NPC1L1_uc003tlc.2_Silent_p.K933K|NPC1L1_uc011kbw.1_Silent_p.K887K|NPC1L1_uc003tla.2_5'Flank	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	933	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	CATACTGGATCTTCTGGGTGA	0.562													0	0	0	1	0	9	56										T	44561680	C	T	44561680	2	4	68	1	0	0	0	0	0	0	0	1	10571	912	32	1		1	NPC1L1	7	44561680	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	442426	44561680	114576983	398	20918										
ZPBP	11055	broad.mit.edu	37	chr7	50070753	50070753	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttttaacgcgatggcattcaGacttaagtaaggaaatttca	8	6	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:50070753G>C	uc003tou.2	-	5	711	c.641C>G	c.(640-642)TCT>TGT	p.S214C	ZPBP_uc011kci.1_Missense_Mutation_p.S140C|ZPBP_uc010kyw.2_Missense_Mutation_p.S213C	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	214					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					ATGGCATTCAGACTTAAGTAA	0.328													0	0	0	1	0	10	85										C	50070753	G	C	50070753	3	2	68	1	0	0	0	0	1	0	0	0	18216	942	33	1	430	1	ZPBP	7	50070753	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5509073	50070753	109067910	399	20919										
COBL	23242	broad.mit.edu	37	chr7	51092923	51092923	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggccgtccttggtgcagaGagagcctgggagggtggagg	21	7	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:51092923G>C	uc003tpr.3	-	12	3836	c.3651C>G	c.(3649-3651)CTC>CTG	p.L1217L	COBL_uc003tps.2_Silent_p.L1227L|COBL_uc011kcl.1_Silent_p.L1170L|COBL_uc003tpp.3_Silent_p.L1003L|COBL_uc003tpq.3_Silent_p.L1111L|COBL_uc003tpo.3_Silent_p.L759L	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	1217										skin(3)|ovary(2)	5	Glioma(55;0.08)					TTGGTGCAGAGAGAGCCTGGG	0.642													0	0	0	1	0	11	34										C	51092923	G	C	51092923	2	2	68	1	0	0	0	0	0	0	0	1	3653	929	33	1		1	COBL	7	51092923	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1022170	51092923	108045740	400	20920										
SBDS	51119	broad.mit.edu	37	chr7	66459252	66459252	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaacgcactgatgagatcttCctttttggcaacctgacctt	7	11	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:66459252C>T	uc003tvm.1	-	2	389	c.205G>A	c.(205-207)GAA>AAA	p.E69K	TYW1_uc003tvn.2_5'Flank|TYW1_uc010lai.2_5'Flank	NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	69					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						ATGAGATCTTCCTTTTTGGCA	0.438			Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				0	0	0	1	0	21	201										T	66459252	C	T	66459252	3	4	68	1	0	0	0	0	1	0	0	0	13857	864	30	1	563	1	SBDS	7	66459252	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	15366329	66459252	92679411	401	20921										
POM121	9883	broad.mit.edu	37	chr7	72414059	72414059	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgagagcaaacctgtgtttgGaggtaaggaggggcgtggac	18	5	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:72414059G>C	uc003twk.2	+	11	3527	c.3527G>C	c.(3526-3528)GGA>GCA	p.G1176A	POM121_uc003twj.2_Missense_Mutation_p.G911A|POM121_uc010lam.1_Missense_Mutation_p.G911A	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1176	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CCTGTGTTTGGAGGTAAGGAG	0.488													0	0	0	1	0	5	20										C	72414059	G	C	72414059	3	2	68	1	0	0	0	0	1	0	0	0	12239	1174	41	1	2770	1	POM121	7	72414059	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5954807	72414059	86724604	402	20922										
CROT	54677	broad.mit.edu	37	chr7	87006664	87006664	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaaaaattaaatttattttaGattattgcagccatccttat	4	5	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:87006664G>A	uc003uit.2	+	10	1122	c.877_splice	c.e10-1	p.I293_splice	CROT_uc003uiu.2_Splice_Site_p.I321_splice	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase						fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	ATTTATTTTAGATTATTGCAG	0.323													0	0	0	1	0	9	19										A	87006664	G	A	87006664	5	1	68	1	0	0	0	0	0	0	1	0	3894	956	33	1	994	1	CROT	7	87006664	Splice_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	14592605	87006664	72131999	403	20923										
DBF4	10926	broad.mit.edu	37	chr7	87536669	87536669	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ataaagagacccaggaaactGaaaaaaagctcctgtttatt	7	7	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:87536669G>C	uc003ujf.1	+	12	1720	c.1216G>C	c.(1216-1218)GAA>CAA	p.E406Q	DBF4_uc003ujh.1_Missense_Mutation_p.E146Q|DBF4_uc003ujg.1_Missense_Mutation_p.E182Q|DBF4_uc011khf.1_Missense_Mutation_p.E173Q	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	406					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				CCAGGAAACTGAAAAAAAGCT	0.383													0	0	0	1	0	12	84										C	87536669	G	C	87536669	3	2	68	1	0	0	0	0	1	0	0	0	4248	1291	45	1	1262	1	DBF4	7	87536669	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	530005	87536669	71601994	404	20924										
MTERF	7978	broad.mit.edu	37	chr7	91503796	91503796	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggaacatcttcaggtcctgCtcattggtaatcatcctatg	8	10	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:91503796C>T	uc003ulb.1	-	2	356	c.312G>A	c.(310-312)GAG>GAA	p.E104E	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Silent_p.E104E|MTERF_uc011khm.1_Silent_p.E84E|MTERF_uc010leu.1_Silent_p.E84E	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	104					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			TCAGGTCCTGCTCATTGGTAA	0.418													0	0	0	1	0	24	119										T	91503796	C	T	91503796	2	4	68	1	0	0	0	0	0	0	0	1	9918	796	28	2		2	MTERF	7	91503796	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3967127	91503796	67634867	405	20925										
CYP3A7	1551	broad.mit.edu	37	chr7	99332708	99332708	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccacggccaagtttgggatGagatccatcactactttcct	8	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:99332708G>C	uc003uru.2	-	1	114	c.9C>G	c.(7-9)CTC>CTG	p.L3L	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_5'UTR|CYP3A5_uc010lgg.2_Silent_p.L3L	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	3					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					AGTTTGGGATGAGATCCATCA	0.507													0	0	0	1	0	11	63										C	99332708	G	C	99332708	2	2	68	1	0	0	0	0	0	0	0	1	4181	1277	45	1		1	CYP3A7	7	99332708	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7828912	99332708	59805955	406	20926										
AP4M1	9179	broad.mit.edu	37	chr7	99704109	99704109	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggacctgcctcgggtgcaagGaggctctcaactctcaggcc	13	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:99704109G>A	uc003utb.3	+	14	1317	c.1109G>A	c.(1108-1110)GGA>GAA	p.G370E	AP4M1_uc010lgl.1_Missense_Mutation_p.G345E|AP4M1_uc003utc.3_Missense_Mutation_p.G377E|AP4M1_uc010lgm.2_Missense_Mutation_p.G242E|AP4M1_uc003utd.2_Missense_Mutation_p.G370E|AP4M1_uc011kjh.1_Missense_Mutation_p.G322E|AP4M1_uc003ute.3_Missense_Mutation_p.G145E|AP4M1_uc003utf.3_Missense_Mutation_p.G242E	NM_004722	NP_004713	O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	370	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGGGTGCAAGGAGGCTCTCAA	0.632													0	0	0	1	0	4	27										A	99704109	G	A	99704109	3	1	68	1	0	0	0	0	1	0	0	0	753	1174	41	1	1163	1	AP4M1	7	99704109	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	371401	99704109	59434554	407	20927										
C7orf43	55262	broad.mit.edu	37	chr7	99755503	99755503	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgggggcagtctatccagtGaaacggtgagtgggaagatg	17	6	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:99755503G>A	uc003utr.2	-	2	650	c.470C>T	c.(469-471)TCA>TTA	p.S157L	C7orf43_uc010lgo.2_5'Flank|C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'Flank|C7orf43_uc003uts.2_5'UTR	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	157											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTATCCAGTGAAACGGTGAG	0.537													0	0	0	1	0	22	37										A	99755503	G	A	99755503	3	1	68	1	0	0	0	0	1	0	0	0	2393	1294	45	1	1312	1	C7orf43	7	99755503	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	51394	99755503	59383160	408	20928										
MUC17	140453	broad.mit.edu	37	chr7	100684352	100684352	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttccaacctcaactcctagtGaaggaatgactccattaact	5	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:100684352G>A	uc003uxp.1	+	3	9708	c.9655G>A	c.(9655-9657)GAA>AAA	p.E3219K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3219	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|52.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACTCCTAGTGAAGGAATGAC	0.498													0	0	0	1	0	93	430										A	100684352	G	A	100684352	3	1	68	1	0	0	0	0	1	0	0	0	9974	1291	45	1	9665	1	MUC17	7	100684352	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	928849	100684352	58454311	409	20929										
MUC17	140453	broad.mit.edu	37	chr7	100684883	100684883	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taccaacctcaagtcctagtGaaggaaccactccattagca	6	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:100684883G>T	uc003uxp.1	+	3	10239	c.10186G>T	c.(10186-10188)GAA>TAA	p.E3396*	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3396	Extracellular (Potential).|55.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AAGTCCTAGTGAAGGAACCAC	0.498													1	0	2.63401e-43	1	3.0645e-43	98	436										T	100684883	G	T	100684883	4	4	68	1	0	0	0	0	0	1	0	0	9974	1291	45	3	10196	3	MUC17	7	100684883	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	531	100684883	58453780	410	20930										
SERPINE1	5054	broad.mit.edu	37	chr7	100771918	100771918	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagaaacccagcagcagattCaagcagctatgggattcaag	11	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:100771918C>T	uc003uxt.2	+	2	392	c.244C>T	c.(244-246)CAA>TAA	p.Q82*	SERPINE1_uc011kkj.1_Nonsense_Mutation_p.Q67*|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	82					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GCAGCAGATTCAAGCAGCTAT	0.577													0	0	0	1	0	8	57										T	100771918	C	T	100771918	4	4	68	1	0	0	0	0	0	1	0	0	14111	827	29	1	246	1	SERPINE1	7	100771918	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	87035	100771918	58366745	411	20931										
PMPCB	9512	broad.mit.edu	37	chr7	102944862	102944862	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttacttcatttacagatctAtaagtcgtaaggacttagtg	7	6	2	1	rs149104855	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:102944862A>G	uc003vbl.2	+	6	695	c.661A>G	c.(661-663)ATA>GTA	p.I221V	PMPCB_uc010liu.1_Missense_Mutation_p.I221V|PMPCB_uc003vbk.1_Missense_Mutation_p.I221V|PMPCB_uc003vbm.2_Missense_Mutation_p.I130V|PMPCB_uc010liv.2_Missense_Mutation_p.I127V|PMPCB_uc010liw.2_Missense_Mutation_p.I130V|PMPCB_uc011kll.1_Missense_Mutation_p.I116V|PMPCB_uc011klm.1_Missense_Mutation_p.I96V	NM_004279	NP_004270	O75439	MPPB_HUMAN	mitochondrial processing peptidase beta subunit	221					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)	4						TTACAGATCTATAAGTCGTAA	0.318													0	0	0	1	0	18	49										G	102944862	A	G	102944862	3	3	68	1	0	0	0	0	1	0	0	0	12141	449	16	5	683	5	PMPCB	7	102944862	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2172944	102944862	56193801	412	20932										
LAMB1	3912	broad.mit.edu	37	chr7	107638920	107638920	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggatcttgggaattgcatatGaagcattttttgtcctccta	9	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:107638920G>T	uc003vew.2	-	4	566	c.231C>A	c.(229-231)TTC>TTA	p.F77L	LAMB1_uc003vev.2_Missense_Mutation_p.F101L|LAMB1_uc003vex.2_Missense_Mutation_p.F77L|LAMB1_uc010ljn.1_Missense_Mutation_p.F163L	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	77	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGCATATGAAGCATTTTT	0.363													1	0	0.000673444	1	0.000690993	10	70										T	107638920	G	T	107638920	3	4	68	1	0	0	0	0	1	0	0	0	8610	1281	45	3	5253	3	LAMB1	7	107638920	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4694058	107638920	51499743	413	20933										
DOCK4	9732	broad.mit.edu	37	chr7	111400253	111400253	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atacactgagcttctgcctgGaagatggtctcatcgggctg	12	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:111400253G>A	uc003vfx.2	-	39	4388	c.4119C>T	c.(4117-4119)TTC>TTT	p.F1373F	DOCK4_uc011kml.1_Silent_p.F254F|DOCK4_uc011kmm.1_Silent_p.F280F|DOCK4_uc003vfw.2_Silent_p.F823F|DOCK4_uc003vfy.2_Silent_p.F1418F	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1373	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTTCTGCCTGGAAGATGGTCT	0.547													0	0	0	1	0	23	113										A	111400253	G	A	111400253	2	1	68	1	0	0	0	0	0	0	0	1	4689	1165	41	1		1	DOCK4	7	111400253	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3761333	111400253	47738410	414	20934										
PTPRZ1	5803	broad.mit.edu	37	chr7	121513587	121513587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcgtttcctcgcttgcattCagctcctctgtgtttgccgc	9	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:121513587C>G	uc003vjy.2	+	1	429	c.34C>G	c.(34-36)CAG>GAG	p.Q12E	PTPRZ1_uc003vjz.2_Missense_Mutation_p.Q12E	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	12					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CGCTTGCATTCAGCTCCTCTG	0.617													0	0	0	1	0	9	24										G	121513587	C	G	121513587	3	3	68	1	0	0	0	0	1	0	0	0	12814	827	29	1	36	1	PTPRZ1	7	121513587	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10113334	121513587	37625076	415	20935										
SND1	27044	broad.mit.edu	37	chr7	127544799	127544799	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttttctcttcttccttaacaGagctattaagaatggcaaag	6	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:127544799G>A	uc003vmi.2	+	14	1681	c.1455_splice	c.e14-1	p.R485_splice	SND1_uc010lle.2_Splice_Site_p.R138_splice	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1						gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						TTCCTTAACAGAGCTATTAAG	0.443													0	0	0	1	0	9	41										A	127544799	G	A	127544799	5	1	68	1	0	0	0	0	0	0	1	0	14844	956	33	1	1508	1	SND1	7	127544799	Splice_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6031212	127544799	31593864	416	20936										
CCDC136	64753	broad.mit.edu	37	chr7	128452893	128452893	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggccaagcagaaagacctGaaggaagagctggatgcctg	14	9	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:128452893G>A	uc003vnv.1	+	14	3040	c.2673G>A	c.(2671-2673)CTG>CTA	p.L891L	CCDC136_uc003vnu.1_Intron|CCDC136_uc003vnw.1_Intron|CCDC136_uc003vnx.1_Silent_p.L707L|CCDC136_uc010llq.1_Silent_p.L260L|CCDC136_uc003vny.1_Silent_p.L501L	NM_022742	NP_073579	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	891	Potential.					integral to membrane	protein binding			ovary(2)	2						AGAAAGACCTGAAGGAAGAGC	0.532													0	0	0	1	0	9	13										A	128452893	G	A	128452893	2	1	68	1	0	0	0	0	0	0	0	1	2770	1277	45	1		1	CCDC136	7	128452893	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	908094	128452893	30685770	417	20937										
MEST	4232	broad.mit.edu	37	chr7	130138063	130138063	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggctccagaaccgcaggatCaaccttctttctcatgacta	8	13	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:130138063C>A	uc003vqg.2	+	5	640	c.423C>A	c.(421-423)ATC>ATA	p.I141I	MEST_uc003vqc.2_Silent_p.I132I|MEST_uc003vqd.2_Silent_p.I132I|MEST_uc003vqf.2_Silent_p.I132I|MEST_uc011kph.1_Silent_p.I127I|MEST_uc010lmg.2_Silent_p.I141I	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	141					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					ACCGCAGGATCAACCTTCTTT	0.483													1	0	5.03518e-11	1	5.60453e-11	19	73										A	130138063	C	A	130138063	2	1	68	1	0	0	0	0	0	0	0	1	9484	816	29	3		3	MEST	7	130138063	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1685170	130138063	29000600	418	20938										
PLXNA4	91584	broad.mit.edu	37	chr7	131825454	131825454	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtgctctgacgtggagcaaGagtccatgaaggtctgagcc	15	9	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:131825454G>A	uc003vra.3	-	30	5571	c.5342C>T	c.(5341-5343)TCT>TTT	p.S1781F	PLXNA4_uc003vqz.3_Missense_Mutation_p.S66F	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1781	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CGTGGAGCAAGAGTCCATGAA	0.542													0	0	0	1	0	16	80										A	131825454	G	A	131825454	3	1	68	1	0	0	0	0	1	0	0	0	12122	942	33	1	354	1	PLXNA4	7	131825454	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1687391	131825454	27313209	419	20939										
EXOC4	60412	broad.mit.edu	37	chr7	132937919	132937919	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagcaaaagcaaagacccctCggggctgctcatctctgtga	10	13	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:132937919C>A	uc003vrk.2	+	1	97	c.62C>A	c.(61-63)TCG>TAG	p.S21*	EXOC4_uc011kpo.1_5'Flank|EXOC4_uc003vri.2_Nonsense_Mutation_p.S21*|EXOC4_uc003vrj.2_Nonsense_Mutation_p.S21*	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	21					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AAAGACCCCTCGGGGCTGCTC	0.617													1	0	2.27111e-07	1	2.43748e-07	12	60										A	132937919	C	A	132937919	4	1	68	1	0	0	0	0	0	1	0	0	5306	893	31	3	64	3	EXOC4	7	132937919	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1112465	132937919	26200744	420	20940										
CALD1	800	broad.mit.edu	37	chr7	134618457	134618457	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagaaaggagagaggcagaaGagagggaaaggatgagggag	21	1	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:134618457G>A	uc003vrz.2	+	5	1396	c.937G>A	c.(937-939)GAG>AAG	p.E313K	CALD1_uc003vry.2_Intron|CALD1_uc003vsa.2_Intron|CALD1_uc003vsb.2_Intron|CALD1_uc010lmm.2_Intron|CALD1_uc011kpt.1_Intron|CALD1_uc003vsc.2_Intron|CALD1_uc003vsd.2_Intron|CALD1_uc011kpu.1_Intron|CALD1_uc011kpv.1_Intron|CALD1_uc003vse.2_Missense_Mutation_p.E177K	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	313					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						agaggcagaagagagggaaag	0.179													0	0	0	1	0	4	2										A	134618457	G	A	134618457	3	1	68	1	0	0	0	0	1	0	0	0	2581	943	33	1	1004	1	CALD1	7	134618457	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1680538	134618457	24520206	421	20941										
ATP6V0A4	50617	broad.mit.edu	37	chr7	138437408	138437408	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctcttgatacgtgtggcatCtgccaccgggaaccagatct	10	13	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:138437408C>T	uc003vuf.2	-	10	1229	c.991G>A	c.(991-993)GAT>AAT	p.D331N	ATP6V0A4_uc003vug.2_Missense_Mutation_p.D331N|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.D331N	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	331	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						CGTGTGGCATCTGCCACCGGG	0.587													0	0	0	1	0	7	29										T	138437408	C	T	138437408	3	4	68	1	0	0	0	0	1	0	0	0	1170	913	32	1	1579	1	ATP6V0A4	7	138437408	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3818951	138437408	20701255	422	20942										
ADCK2	90956	broad.mit.edu	37	chr7	140374519	140374519	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcaagtggcttagcttgcctGagattgtggaggaatttgag	14	5	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:140374519G>A	uc003vvy.1	+	2	1220	c.1042G>A	c.(1042-1044)GAG>AAG	p.E348K	ADCK2_uc003vvz.2_Missense_Mutation_p.E348K	NM_052853	NP_443085	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	348	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity				0	Melanoma(164;0.00956)					TAGCTTGCCTGAGATTGTGGA	0.522													0	0	0	1	0	9	28										A	140374519	G	A	140374519	3	1	68	1	0	0	0	0	1	0	0	0	289	1291	45	1	1048	1	ADCK2	7	140374519	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1937111	140374519	18764144	423	20943										
MGAM	8972	broad.mit.edu	37	chr7	141731552	141731552	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttggtggacaaaggaatttGagctttttcacaatcaagta	9	5	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:141731552G>C	uc003vwy.2	+	13	1597	c.1543G>C	c.(1543-1545)GAG>CAG	p.E515Q		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	515	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AAAGGAATTTGAGCTTTTTCA	0.368													0	0	0	1	0	16	82										C	141731552	G	C	141731552	3	2	68	1	0	0	0	0	1	0	0	0	9541	1291	45	1	1589	1	MGAM	7	141731552	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1357033	141731552	17407111	424	20944										
FAM131B	9715	broad.mit.edu	37	chr7	143053718	143053718	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acgtcagacaccttccggctGagagcggtagacatctcagg	12	12	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:143053718G>C	uc003wct.2	-	6	2630	c.924C>G	c.(922-924)CTC>CTG	p.L308L	FAM131B_uc010loz.2_Silent_p.L276L|FAM131B_uc003wcu.3_Silent_p.L308L|FAM131B_uc010lpa.2_Silent_p.L336L	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	308											0	Melanoma(164;0.205)					CCTTCCGGCTGAGAGCGGTAG	0.582													0	0	0	1	0	33	143										C	143053718	G	C	143053718	2	2	68	1	0	0	0	0	0	0	0	1	5440	1277	45	1		1	FAM131B	7	143053718	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1322166	143053718	16084945	425	20945										
OR2A2	442361	broad.mit.edu	37	chr7	143806767	143806767	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctcctctgtggactcttctCtgtcttctatacactcaccc	4	16	7	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:143806767C>T	uc011ktz.1	+	1	92	c.92C>T	c.(91-93)TCT>TTT	p.S31F		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					GGACTCTTCTCTGTCTTCTAT	0.517													0	0	0	1	0	19	126										T	143806767	C	T	143806767	3	4	68	1	0	0	0	0	1	0	0	0	10977	913	32	1	94	1	OR2A2	7	143806767	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	753049	143806767	15331896	426	20946										
ARHGEF35	445328	broad.mit.edu	37	chr7	143884109	143884109	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgggctggtgagagcatctGatgggctctagcaagggaga	17	6	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:143884109G>A	uc003wdz.1	-	2	1486	c.1368C>T	c.(1366-1368)ATC>ATT	p.I456I		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	456											0						GAGAGCATCTGATGGGCTCTA	0.488													0	0	0	1	0	8	30										A	143884109	G	A	143884109	2	1	68	1	0	0	0	0	0	0	0	1	905	1280	45	1		1	ARHGEF35	7	143884109	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	77342	143884109	15254554	427	20947										
GIMAP2	26157	broad.mit.edu	37	chr7	150389979	150389979	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaaggaactaatggactgtaTtgaggatctgttgatggaga	14	3	1	3	rs138926685		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:150389979T>C	uc003who.2	+	3	693	c.605T>C	c.(604-606)ATT>ACT	p.I202T	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	202						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATGGACTGTATTGAGGATCTG	0.458													0	0	0	1	0	59	88										C	150389979	T	C	150389979	3	2	68	1	0	0	0	0	1	0	0	0	6380	1493	52	5	611	5	GIMAP2	7	150389979	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	6505870	150389979	8748684	428	20948										
KCNH2	3757	broad.mit.edu	37	chr7	150649798	150649798	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaggcagccgagtagggtgtGaagacagccgtgtagatgac	16	7	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:150649798G>A	uc003wic.2	-	6	1285	c.1272C>T	c.(1270-1272)TTC>TTT	p.F424F	KCNH2_uc003wib.2_Silent_p.F84F|KCNH2_uc011kux.1_Silent_p.F328F|KCNH2_uc003wid.2_Silent_p.F84F|KCNH2_uc003wie.2_Silent_p.F424F	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	424	Helical; Name=Segment S1; (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	AGTAGGGTGTGAAGACAGCCG	0.632													0	0	0	1	0	17	93										A	150649798	G	A	150649798	2	1	68	1	0	0	0	0	0	0	0	1	8032	1281	45	1		1	KCNH2	7	150649798	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	259819	150649798	8488865	429	20949										
NOS3	4846	broad.mit.edu	37	chr7	150709517	150709517	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcactggcattgcccccttCcggggattctggcaggagcg	15	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:150709517C>T	uc003wif.2	+	24	3359	c.3063C>T	c.(3061-3063)TTC>TTT	p.F1021F	NOS3_uc011kuy.1_Silent_p.F815F|ATG9B_uc003wig.3_RNA|ATG9B_uc011kvc.1_3'UTR	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	1021	NADP (By similarity).				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TTGCCCCCTTCCGGGGATTCT	0.617													0	0	0	1	0	7	6										T	150709517	C	T	150709517	2	4	68	1	0	0	0	0	0	0	0	1	10544	854	30	1		1	NOS3	7	150709517	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	59719	150709517	8429146	430	20950										
INSIG1	3638	broad.mit.edu	37	chr7	155090019	155090019	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccagattgcacgaccacttCtggagctgctcctgtgcgca	10	15	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:155090019C>T	uc003wly.2	+	2	235	c.24C>T	c.(22-24)TTC>TTT	p.F8F	INSIG1_uc011kvu.1_Silent_p.F8F|INSIG1_uc003wlz.2_Silent_p.F8F	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1	8	Cytoplasmic.				cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACGACCACTTCTGGAGCTGCT	0.642													0	0	0	1	0	5	11										T	155090019	C	T	155090019	2	4	68	1	0	0	0	0	0	0	0	1	7765	912	32	1		1	INSIG1	7	155090019	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4380502	155090019	4048644	431	20951										
WDR60	55112	broad.mit.edu	37	chr7	158663899	158663899	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agaagctgcgtaaggagtctGagatggaccttcctgaacat	12	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr7:158663899G>A	uc003woe.3	+	3	294	c.136G>A	c.(136-138)GAG>AAG	p.E46K		NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	46										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TAAGGAGTCTGAGATGGACCT	0.547													0	0	0	1	0	8	18										A	158663899	G	A	158663899	3	1	68	1	0	0	0	0	1	0	0	0	17308	1291	45	1	146	1	WDR60	7	158663899	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3573880	158663899	474764	432	20952										
DLC1	10395	broad.mit.edu	37	chr8	12946138	12946138	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgctgttctttaagtaggcGctttaagatttcctctggca	10	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:12946138G>A	uc003wwm.2	-	16	4594	c.4150C>T	c.(4150-4152)CGC>TGC	p.R1384C	DLC1_uc003wwk.1_Missense_Mutation_p.R947C|DLC1_uc003wwl.1_Missense_Mutation_p.R981C|DLC1_uc011kxx.1_Missense_Mutation_p.R873C	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1384	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTAAGTAGGCGCTTTAAGATT	0.453													0	0	0	1	0	25	71										A	12946138	G	A	12946138	3	1	68	1	0	0	0	0	1	0	0	0	4550	1087	38	2	448	2	DLC1	8	12946138	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		12946138	133417884	433	20953										
LZTS1	11178	broad.mit.edu	37	chr8	20110394	20110394	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgctccttcatgaggctctCgagctcctgccggagctgcc	11	16	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:20110394C>A	uc003wzr.2	-	2	1159	c.1048G>T	c.(1048-1050)GAG>TAG	p.E350*	LZTS1_uc010ltg.1_Nonsense_Mutation_p.E350*	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	350	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		ATGAGGCTCTCGAGCTCCTGC	0.652													1	0	0.0477658	1	0.0481479	9	20										A	20110394	C	A	20110394	4	1	68	1	0	0	0	0	0	1	0	0	9138	893	31	3	750	3	LZTS1	8	20110394	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7164256	20110394	126253628	434	20954										
EPB49	2039	broad.mit.edu	37	chr8	21927731	21927731	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcagaccaagcacctcatcGaggatctcatcatcgagtca	7	14	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:21927731G>A	uc011kyt.1	+	8	719	c.490G>A	c.(490-492)GAG>AAG	p.E164K	EPB49_uc010ltl.2_Missense_Mutation_p.E164K|EPB49_uc011kys.1_Missense_Mutation_p.E124K|EPB49_uc010ltn.2_Missense_Mutation_p.E139K|EPB49_uc011kyu.1_Missense_Mutation_p.E164K|EPB49_uc011kyv.1_Missense_Mutation_p.E164K|EPB49_uc010ltq.2_Missense_Mutation_p.E164K	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	164					actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		GCACCTCATCGAGGATCTCAT	0.612													0	0	0	1	0	18	126										A	21927731	G	A	21927731	3	1	68	1	0	0	0	0	1	0	0	0	5159	1059	37	1	516	1	EPB49	8	21927731	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1817337	21927731	124436291	435	20955										
C8orf86	389649	broad.mit.edu	37	chr8	38370103	38370103	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggaggcttgagacaggaaaGagtttgataggttccaggac	15	6	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:38370103G>C	uc003xlx.1	-	3	499	c.474C>G	c.(472-474)CTC>CTG	p.L158L		NM_207412	NP_997295	Q6ZUL3	CH086_HUMAN	hypothetical protein LOC389649	158											0						agacaggaaagagtttgatag	0.055													0	0	0	1	0	9	49										C	38370103	G	C	38370103	2	2	68	1	0	0	0	0	0	0	0	1	2442	929	33	1		1	C8orf86	8	38370103	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	16442372	38370103	107993919	436	20956										
ZMAT4	79698	broad.mit.edu	37	chr8	40532405	40532405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatagggagatgcgaccaccGgagcagtgtccatccgtggg	16	10	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:40532405G>A	uc003xnr.2	-	5	541	c.395C>T	c.(394-396)CCG>CTG	p.P132L	ZMAT4_uc003xns.2_Intron	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	132						nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TGCGACCACCGGAGCAGTGTC	0.517													0	0	0	1	0	74	176										A	40532405	G	A	40532405	3	1	68	1	0	0	0	0	1	0	0	0	17691	1116	39	2	306	2	ZMAT4	8	40532405	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2162302	40532405	105831617	437	20957										
SGK196	84197	broad.mit.edu	37	chr8	42977680	42977680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acccctggtgaaccacagctCcgggatgctggtgaagtgcg	14	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:42977680C>T	uc003xpw.2	+	5	972	c.713C>T	c.(712-714)TCC>TTC	p.S238F		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	238	Protein kinase.					integral to membrane	ATP binding|protein kinase activity				0						AACCACAGCTCCGGGATGCTG	0.557													0	0	0	1	0	8	33										T	42977680	C	T	42977680	3	4	68	1	0	0	0	0	1	0	0	0	14208	855	30	1	719	1	SGK196	8	42977680	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2445275	42977680	103386342	438	20958										
PXDNL	137902	broad.mit.edu	37	chr8	52321993	52321993	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caggttgttgcacgtgccgtCgtgggcgcggtacttcgcat	15	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:52321993C>T	uc003xqu.3	-	17	2292	c.2191G>A	c.(2191-2193)GAC>AAC	p.D731N	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	731					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CACGTGCCGTCGTGGGCGCGG	0.677													0	0	0	1	0	5	24										T	52321993	C	T	52321993	3	4	68	1	0	0	0	0	1	0	0	0	12848	884	31	1	2228	1	PXDNL	8	52321993	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9344313	52321993	94042029	439	20959										
ST18	9705	broad.mit.edu	37	chr8	53062372	53062372	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcttggtcacaaagagcctGatagaatgctgcattgacca	9	10	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:53062372G>A	uc003xqz.2	-	11	2128	c.1972C>T	c.(1972-1974)CAG>TAG	p.Q658*	ST18_uc011ldq.1_Nonsense_Mutation_p.Q305*|ST18_uc011ldr.1_Nonsense_Mutation_p.Q623*|ST18_uc011lds.1_Nonsense_Mutation_p.Q563*|ST18_uc003xra.2_Nonsense_Mutation_p.Q658*|ST18_uc003xrb.2_Nonsense_Mutation_p.Q658*	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	658						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CAAAGAGCCTGATAGAATGCT	0.458													0	0	0	1	0	12	56										A	53062372	G	A	53062372	4	1	68	1	0	0	0	0	0	1	0	0	15211	1299	45	1	1215	1	ST18	8	53062372	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	740379	53062372	93301650	440	20960										
ZFHX4	79776	broad.mit.edu	37	chr8	77618762	77618762	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cataatctgcacttgggcctCgccccggcggaagcagagct	12	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:77618762C>G	uc003yav.2	+	2	2826	c.2439C>G	c.(2437-2439)CTC>CTG	p.L813L	ZFHX4_uc003yat.1_Silent_p.L813L|ZFHX4_uc003yau.1_Silent_p.L813L|ZFHX4_uc003yaw.1_Silent_p.L813L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	813						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTGGGCCTCGCCCCGGCGG	0.507										HNSCC(33;0.089)			0	0	0	1	0	3	17										G	77618762	C	G	77618762	2	3	68	1	0	0	0	0	0	0	0	1	17632	871	31	1		1	ZFHX4	8	77618762	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	24556390	77618762	68745260	441	20961										
ZFHX4	79776	broad.mit.edu	37	chr8	77620217	77620217	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcctgtgactattacaccaaCagtgtggataaattacgctt	8	9	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:77620217C>G	uc003yav.2	+	3	3336	c.2949C>G	c.(2947-2949)AAC>AAG	p.N983K	ZFHX4_uc003yat.1_Missense_Mutation_p.N983K|ZFHX4_uc003yau.1_Missense_Mutation_p.N1009K|ZFHX4_uc003yaw.1_Missense_Mutation_p.N983K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	983	C2H2-type 6.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATTACACCAACAGTGTGGATA	0.473										HNSCC(33;0.089)			0	0	0	1	0	20	103										G	77620217	C	G	77620217	3	3	68	1	0	0	0	0	1	0	0	0	17632	477	17	4	3033	4	ZFHX4	8	77620217	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1455	77620217	68743805	442	20962										
LRRCC1	85444	broad.mit.edu	37	chr8	86035736	86035736	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaaagtgactatggaaacaGaaaagaatgcaatagaaaag	10	3	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:86035736G>A	uc003ycw.2	+	7	1173	c.1019G>A	c.(1018-1020)AGA>AAA	p.R340K	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Missense_Mutation_p.R41K|LRRCC1_uc003ycx.2_Missense_Mutation_p.R247K|LRRCC1_uc003ycy.2_Missense_Mutation_p.R320K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	340					cell division|mitosis	centriole|nucleus					0						TATGGAAACAGAAAAGAATGC	0.318													0	0	0	1	0	24	193										A	86035736	G	A	86035736	3	1	68	1	0	0	0	0	1	0	0	0	9026	942	33	1	1045	1	LRRCC1	8	86035736	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8415519	86035736	60328286	443	20963										
DECR1	1666	broad.mit.edu	37	chr8	91055005	91055005	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaatgcgattcaatgtgattCaaccagggcctataaaaacc	8	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:91055005C>T	uc003yek.1	+	7	856	c.715C>T	c.(715-717)CAA>TAA	p.Q239*	DECR1_uc011lgc.1_Nonsense_Mutation_p.Q230*|DECR1_uc011lgd.1_RNA	NM_001359	NP_001350	Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1 precursor	239					fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)			CAATGTGATTCAACCAGGGCC	0.308													0	0	0	1	0	18	175										T	91055005	C	T	91055005	4	4	68	1	0	0	0	0	0	1	0	0	4382	827	29	1	741	1	DECR1	8	91055005	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5019269	91055005	55309017	444	20964										
DPY19L4	286148	broad.mit.edu	37	chr8	95782795	95782795	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttctcttgcaatggttataGaagggtaagtgtactttatt	10	4	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:95782795G>C	uc003ygx.2	+	13	1574	c.1450G>C	c.(1450-1452)GAA>CAA	p.E484Q		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	484	Helical; (Potential).					integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					AATGGTTATAGAAGGGTAAGT	0.239													0	0	0	1	0	14	62										C	95782795	G	C	95782795	3	2	68	1	0	0	0	0	1	0	0	0	4743	943	33	1	1500	1	DPY19L4	8	95782795	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4727790	95782795	50581227	445	20965										
CCNE2	9134	broad.mit.edu	37	chr8	95902660	95902660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacctctaaaagccagtctaGaagtatggacctcatctgtg	8	10	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:95902660G>C	uc003yhc.2	-	6	545	c.436C>G	c.(436-438)CTA>GTA	p.L146V	CCNE2_uc003yhd.2_Missense_Mutation_p.L146V	NM_057749	NP_477097	O96020	CCNE2_HUMAN	cyclin E2	146					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)					AGCCAGTCTAGAAGTATGGAC	0.363													0	0	0	1	0	78	143										C	95902660	G	C	95902660	3	2	68	1	0	0	0	0	1	0	0	0	2921	933	33	1	806	1	CCNE2	8	95902660	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	119865	95902660	50461362	446	20966										
KCNS2	3788	broad.mit.edu	37	chr8	99440523	99440523	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctccttcagccaggagatcGagtactggggcatcaacgag	12	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:99440523G>A	uc003yin.2	+	2	666	c.316G>A	c.(316-318)GAG>AAG	p.E106K		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	106	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CCAGGAGATCGAGTACTGGGG	0.557													0	0	0	1	0	48	221										A	99440523	G	A	99440523	3	1	68	1	0	0	0	0	1	0	0	0	8089	1059	37	1	318	1	KCNS2	8	99440523	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3537863	99440523	46923499	447	20967										
VPS13B	157680	broad.mit.edu	37	chr8	100874104	100874104	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaccggcaggaggagtggcgGcggcagctccccgagagcct	17	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:100874104G>T	uc003yiv.2	+	58	11331	c.11220G>T	c.(11218-11220)CGG>CGT	p.R3740R	VPS13B_uc003yiw.2_Silent_p.R3715R	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3740					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGGAGTGGCGGCGGCAGCTCC	0.672													1	0	3.07112e-06	1	3.24359e-06	11	27										T	100874104	G	T	100874104	2	4	68	1	0	0	0	0	0	0	0	1	17187	1190	42	4		4	VPS13B	8	100874104	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1433581	100874104	45489918	448	20968										
SNX31	169166	broad.mit.edu	37	chr8	101586104	101586104	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagctttcttcagagatcttCttcctttatgttcccaaaaa	5	10	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:101586104C>T	uc003yjr.2	-	14	1463	c.1312G>A	c.(1312-1314)GAA>AAA	p.E438K	SNX31_uc011lha.1_Missense_Mutation_p.E233K|SNX31_uc011lhb.1_Missense_Mutation_p.E339K	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	438					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CAGAGATCTTCTTCCTTTATG	0.373													0	0	0	1	0	27	229										T	101586104	C	T	101586104	3	4	68	1	0	0	0	0	1	0	0	0	14901	922	32	1	14	1	SNX31	8	101586104	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	712000	101586104	44777918	449	20969										
SNX31	169166	broad.mit.edu	37	chr8	101586144	101586144	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acgcagtcatctttagctatCttaatcttgctttttcttga	5	9	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:101586144C>G	uc003yjr.2	-	14	1423	c.1272G>C	c.(1270-1272)AAG>AAC	p.K424N	SNX31_uc011lha.1_Missense_Mutation_p.K219N|SNX31_uc011lhb.1_Missense_Mutation_p.K325N	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	424					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CTTTAGCTATCTTAATCTTGC	0.338													0	0	0	1	0	15	250										G	101586144	C	G	101586144	3	3	68	1	0	0	0	0	1	0	0	0	14901	912	32	1	54	1	SNX31	8	101586144	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	40	101586144	44777878	450	20970										
UBR5	51366	broad.mit.edu	37	chr8	103341574	103341574	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taaagttctcctttactgctGacagccagaagttcagaata	7	9	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:103341574G>A	uc003ykr.1	-	10	1185	c.1152C>T	c.(1150-1152)GTC>GTT	p.V384V	UBR5_uc003yks.1_Silent_p.V384V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	384					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTTACTGCTGACAGCCAGAA	0.333													0	0	0	1	0	62	692										A	103341574	G	A	103341574	2	1	68	1	0	0	0	0	0	0	0	1	16902	1277	45	1		1	UBR5	8	103341574	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1755430	103341574	43022448	451	20971										
TM7SF4	81501	broad.mit.edu	37	chr8	105361098	105361098	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagctggcacagggatcgtCatcttgggacacgtagaaaa	13	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:105361098C>A	uc003ylx.1	+	2	367	c.318C>A	c.(316-318)GTC>GTA	p.V106V		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	106	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CAGGGATCGTCATCTTGGGAC	0.438													1	0	1.45105e-14	1	1.64714e-14	17	193										A	105361098	C	A	105361098	2	1	68	1	0	0	0	0	0	0	0	1	15973	813	29	3		3	TM7SF4	8	105361098	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2019524	105361098	41002924	452	20972										
TM7SF4	81501	broad.mit.edu	37	chr8	105361151	105361151	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctttaaaggtctcctagatgGtatgacttgcaacctaaggg	10	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:105361151G>A	uc003ylx.1	+	2	420	c.371G>A	c.(370-372)GGT>GAT	p.G124D		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	124					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTCCTAGATGGTATGACTTGC	0.418													0	0	0	1	0	28	230										A	105361151	G	A	105361151	3	1	68	1	0	0	0	0	1	0	0	0	15973	1261	44	2	373	2	TM7SF4	8	105361151	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	53	105361151	41002871	453	20973										
PKHD1L1	93035	broad.mit.edu	37	chr8	110456939	110456939	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agaagaaagtagtgaggattCaattacatgtcatattgacc	9	5	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:110456939C>T	uc003yne.2	+	38	4945	c.4841C>T	c.(4840-4842)TCA>TTA	p.S1614L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1614	Extracellular (Potential).|IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTGAGGATTCAATTACATGT	0.383										HNSCC(38;0.096)			0	0	0	1	0	38	237										T	110456939	C	T	110456939	3	4	68	1	0	0	0	0	1	0	0	0	11972	838	29	1	4991	1	PKHD1L1	8	110456939	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5095788	110456939	35907083	454	20974										
PKHD1L1	93035	broad.mit.edu	37	chr8	110492237	110492237	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taggaacatggattgtagctGacatagatatgccatcaatg	10	6	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:110492237G>A	uc003yne.2	+	55	9300	c.9196G>A	c.(9196-9198)GAC>AAC	p.D3066N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3066	Extracellular (Potential).|G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATTGTAGCTGACATAGATAT	0.338										HNSCC(38;0.096)			0	0	0	1	0	5	13										A	110492237	G	A	110492237	3	1	68	1	0	0	0	0	1	0	0	0	11972	1290	45	1	9414	1	PKHD1L1	8	110492237	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	35298	110492237	35871785	455	20975										
COL14A1	7373	broad.mit.edu	37	chr8	121259858	121259858	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttttctactcagtaccatCctcggggccccagaacttgc	7	15	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:121259858C>T	uc003yox.2	+	21	2751	c.2486C>T	c.(2485-2487)TCC>TTC	p.S829F	COL14A1_uc003yoy.2_Missense_Mutation_p.S507F	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	829	Fibronectin type-III 7.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCAGTACCATCCTCGGGGCCC	0.473													0	0	0	1	0	9	86										T	121259858	C	T	121259858	3	4	68	1	0	0	0	0	1	0	0	0	3671	855	30	1	2564	1	COL14A1	8	121259858	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10767621	121259858	25104164	456	20976										
WDR67	93594	broad.mit.edu	37	chr8	124153062	124153062	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcagatgcagatgcctataGacgaaaagtggatcttgaag	12	6	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:124153062G>A	uc003ypp.1	+	18	2651	c.2561G>A	c.(2560-2562)AGA>AAA	p.R854K	WDR67_uc011lig.1_Missense_Mutation_p.R823K|WDR67_uc011lih.1_Missense_Mutation_p.R744K|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.R488K|WDR67_uc003ypt.1_Missense_Mutation_p.R311K|WDR67_uc003ypu.1_Missense_Mutation_p.R311K	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	854	Potential.					centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GATGCCTATAGACGAAAAGTG	0.338													0	0	0	1	0	20	101										A	124153062	G	A	124153062	3	1	68	1	0	0	0	0	1	0	0	0	17315	942	33	1	2631	1	WDR67	8	124153062	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2893204	124153062	22210960	457	20977										
FBXO32	114907	broad.mit.edu	37	chr8	124516888	124516888	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgcagagctgaagggtatCtccatactgctctttccttg	9	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:124516888C>G	uc003yqr.2	-	8	1126	c.934G>C	c.(934-936)GAT>CAT	p.D312H	FBXO32_uc003yqq.2_Missense_Mutation_p.D167H|FBXO32_uc010mdk.2_Missense_Mutation_p.D219H	NM_058229	NP_478136	Q969P5	FBX32_HUMAN	F-box only protein 32 isoform 1	312										skin(3)|breast(2)|lung(1)	6	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TGAAGGGTATCTCCATACTGC	0.498													0	0	0	1	0	9	48										G	124516888	C	G	124516888	3	3	68	1	0	0	0	0	1	0	0	0	5742	913	32	1	141	1	FBXO32	8	124516888	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	363826	124516888	21847134	458	20978										
ZC3H3	23144	broad.mit.edu	37	chr8	144620768	144620768	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctgtccccaaggagctgtgGagcacagctggccacggaat	13	13	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:144620768G>C	uc003yyd.2	-	2	798	c.769C>G	c.(769-771)CCA>GCA	p.P257A		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	257					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			AGGAGCTGTGGAGCACAGCTG	0.667													0	0	0	1	0	17	51										C	144620768	G	C	144620768	3	2	68	1	0	0	0	0	1	0	0	0	17566	1174	41	1	2121	1	ZC3H3	8	144620768	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	20103880	144620768	1743254	459	20979										
FAM83H	286077	broad.mit.edu	37	chr8	144810168	144810168	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccggcgcccagggtgaagTcatccgggtccgcgaaaccc	14	16	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:144810168T>C	uc003yzk.2	-	5	1532	c.1463A>G	c.(1462-1464)GAC>GGC	p.D488G	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	488					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CAGGGTGAAGTCATCCGGGTC	0.746													0	0	0	1	0	4	7										C	144810168	T	C	144810168	3	2	68	1	0	0	0	0	1	0	0	0	5640	1667	58	5	2080	5	FAM83H	8	144810168	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	189400	144810168	1553854	460	20980										
SCRIB	23513	broad.mit.edu	37	chr8	144897387	144897387	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcgggcggccgctcaccttGggcagctcgcgcagctggtt	16	14	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:144897387G>A	uc003yzp.1	-	1	163	c.156C>T	c.(154-156)CCC>CCT	p.P52P	SCRIB_uc003yzo.1_Silent_p.P52P|MIR937_hsa-mir-937|MI0005759_5'Flank	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	52	LRR 1.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGCTCACCTTGGGCAGCTCGC	0.716													0	0	0	1	0	5	6										A	144897387	G	A	144897387	2	1	68	1	0	0	0	0	0	0	0	1	13937	1335	47	2		2	SCRIB	8	144897387	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	87219	144897387	1466635	461	20981										
PLEC	5339	broad.mit.edu	37	chr8	144993918	144993918	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctccaggtagatgccggcGaggcagccactgccctgcag	13	15	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:144993918G>A	uc003zaf.1	-	32	10652	c.10482C>T	c.(10480-10482)CTC>CTT	p.L3494L	PLEC_uc003zab.1_Silent_p.L3357L|PLEC_uc003zac.1_Silent_p.L3361L|PLEC_uc003zad.2_Silent_p.L3357L|PLEC_uc003zae.1_Silent_p.L3325L|PLEC_uc003zag.1_Silent_p.L3335L|PLEC_uc003zah.2_Silent_p.L3343L|PLEC_uc003zaj.2_Silent_p.L3384L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3494	Plectin 12.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGATGCCGGCGAGGCAGCCAC	0.657													0	0	0	1	0	16	41										A	144993918	G	A	144993918	2	1	68	1	0	0	0	0	0	0	0	1	12052	1045	37	1		1	PLEC	8	144993918	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	96531	144993918	1370104	462	20982										
PARP10	84875	broad.mit.edu	37	chr8	145059118	145059118	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagagaccccatgggcatcGagctgacttgctctgcctgt	11	14	1	2	rs148128554		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:145059118G>C	uc003zal.3	-	5	1160	c.1052C>G	c.(1051-1053)TCG>TGG	p.S351W	PARP10_uc003zak.3_Missense_Mutation_p.S57W|PARP10_uc011lku.1_Missense_Mutation_p.S363W|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.S351W|PARP10_uc010mfn.1_Missense_Mutation_p.S266W|PARP10_uc010mfo.1_3'UTR	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	351						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CATGGGCATCGAGCTGACTTG	0.627													0	0	0	1	0	15	126										C	145059118	G	C	145059118	3	2	68	1	0	0	0	0	1	0	0	0	11455	1059	37	1	2053	1	PARP10	8	145059118	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	65200	145059118	1304904	463	20983										
CPSF1	29894	broad.mit.edu	37	chr8	145625827	145625827	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagatgacggggtgcaccttCtgcgtgatgttcagtgagat	14	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:145625827C>T	uc003zcj.2	-	8	822	c.747G>A	c.(745-747)CAG>CAA	p.Q249Q	CPSF1_uc003zck.1_Silent_p.Q171Q|CPSF1_uc011lle.1_Silent_p.Q249Q|MIR1234_hsa-mir-1234|MI0006324_5'Flank|CPSF1_uc011llf.1_Silent_p.Q249Q	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	249					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GGTGCACCTTCTGCGTGATGT	0.647													0	0	0	1	0	6	79										T	145625827	C	T	145625827	2	4	68	1	0	0	0	0	0	0	0	1	3824	912	32	1		1	CPSF1	8	145625827	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	566709	145625827	738195	464	20984										
GPT	2875	broad.mit.edu	37	chr8	145729780	145729780	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcatgaacccgcgtgtgcgGagagtggagtacgcagtgcg	18	9	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:145729780G>A	uc011lli.1	+	2	250	c.93G>A	c.(91-93)CGG>CGA	p.R31R	GPT_uc011llj.1_Silent_p.R31R|GPT_uc003zdh.3_Silent_p.R31R	NM_005309	NP_005300	P24298	ALAT1_HUMAN	glutamic pyruvate transaminase	31					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|central_nervous_system(1)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CGCGTGTGCGGAGAGTGGAGT	0.672													0	0	0	1	0	5	22										A	145729780	G	A	145729780	2	1	68	1	0	0	0	0	0	0	0	1	6737	1161	41	1		1	GPT	8	145729780	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	103953	145729780	634242	465	20985										
RECQL4	9401	broad.mit.edu	37	chr8	145739392	145739392	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccgtggaggtcaggctcttCagccacagccaggtgctgtg	14	13	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr8:145739392C>T	uc003zdj.2	-	12	2010	c.1978G>A	c.(1978-1980)GAA>AAA	p.E660K		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	660	Helicase ATP-binding.				DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCAGGCTCTTCAGCCACAGCC	0.657			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				0	0	0	1	0	6	5										T	145739392	C	T	145739392	3	4	68	1	0	0	0	0	1	0	0	0	13202	835	29	1	1689	1	RECQL4	8	145739392	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9612	145739392	624630	466	20986										
KANK1	23189	broad.mit.edu	37	chr9	713026	713026	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtttgacaggccatcagctGtgaagaccaaagagtcaggt	13	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:713026G>A	uc003zgl.1	+	7	2909	c.2260G>A	c.(2260-2262)GTG>ATG	p.V754M	KANK1_uc003zgm.2_Missense_Mutation_p.V754M|KANK1_uc003zgn.1_Missense_Mutation_p.V754M|KANK1_uc003zgo.1_Missense_Mutation_p.V754M|KANK1_uc003zgp.1_Missense_Mutation_p.V754M|KANK1_uc003zgq.2_Missense_Mutation_p.V596M|KANK1_uc003zgr.1_Missense_Mutation_p.V596M|KANK1_uc003zgs.1_Missense_Mutation_p.V596M	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	754					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GCCATCAGCTGTGAAGACCAA	0.498													0	0	0	1	0	25	24										A	713026	G	A	713026	3	1	68	1	0	0	0	0	1	0	0	0	7976	1377	48	2	2266	2	KANK1	9	713026	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		713026	140500405	467	20987										
GLDC	2731	broad.mit.edu	37	chr9	6595073	6595073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caatatgctccagcccatggGaaccatggtagattgcaaac	9	11	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:6595073G>A	uc003zkc.2	-	9	1395	c.1202C>T	c.(1201-1203)TCC>TTC	p.S401F		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	401					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGCCCATGGGAACCATGGTA	0.418													0	0	0	1	0	34	123										A	6595073	G	A	6595073	3	1	68	1	0	0	0	0	1	0	0	0	6433	1174	41	1	1928	1	GLDC	9	6595073	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5882047	6595073	134618358	468	20988										
PTPRD	5789	broad.mit.edu	37	chr9	8484313	8484313	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatttctcaggcttcaggttGacaattaacttctgtgtggc	10	8	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:8484313G>A	uc003zkk.2	-	29	3930	c.3219C>T	c.(3217-3219)GTC>GTT	p.V1073V	PTPRD_uc003zkp.2_Silent_p.V662V|PTPRD_uc003zkq.2_Silent_p.V662V|PTPRD_uc003zkr.2_Silent_p.V657V|PTPRD_uc003zks.2_Silent_p.V652V|PTPRD_uc003zkl.2_Silent_p.V1064V|PTPRD_uc003zkm.2_Silent_p.V1060V|PTPRD_uc003zkn.2_Silent_p.V662V|PTPRD_uc003zko.2_Silent_p.V659V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1073	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCTTCAGGTTGACAATTAACT	0.423										TSP Lung(15;0.13)			0	0	0	1	0	21	25										A	8484313	G	A	8484313	2	1	68	1	0	0	0	0	0	0	0	1	12799	1277	45	1		1	PTPRD	9	8484313	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1889240	8484313	132729118	469	20989										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18657715	18657715	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccaccgatggagggagacgGatttctttccttgctcagca	11	11	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:18657715G>C	uc003zne.3	+	8	1040	c.913G>C	c.(913-915)GAT>CAT	p.D305H	ADAMTSL1_uc003znb.2_Missense_Mutation_p.D305H|ADAMTSL1_uc003znc.3_Missense_Mutation_p.D305H	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	305						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GAGGGAGACGGATTTCTTTCC	0.463													0	0	0	1	0	5	34										C	18657715	G	C	18657715	3	2	68	1	0	0	0	0	1	0	0	0	274	1174	41	1	943	1	ADAMTSL1	9	18657715	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10173402	18657715	122555716	470	20990										
CDKN2A	1029	broad.mit.edu	37	chr9	21974792	21974792	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgtggccagccagtcagccGaaggctccatgctgctcccc	11	18	1	0	rs141798398		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:21974792G>T	uc003zpk.2	-	1	247	c.35C>A	c.(34-36)TCG>TAG	p.S12*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Nonsense_Mutation_p.S12*|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	12	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.S12*(3)|p.S12fs*6(1)|p.S12fs*14(1)|p.S7_A19del(1)|p.M9_A20>X(1)|p.P11_S12insAAGSSMEP(1)|p.S12fs*20(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCAGTCAGCCGAAGGCTCCAT	0.761		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			1	0	1.05317e-09	1	1.16403e-09	11	20										T	21974792	G	T	21974792	4	4	68	1	0	0	0	0	0	1	0	0	3161	1059	37	3	648	3	CDKN2A	9	21974792	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3317077	21974792	119238639	471	20991										
ACO1	48	broad.mit.edu	37	chr9	32421006	32421006	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagttgatgaagttagtatCacgtacctggtgcaaacagg	11	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:32421006C>T	uc003zqw.3	+	8	1106	c.951C>T	c.(949-951)ATC>ATT	p.I317I	ACO1_uc010mjh.1_Silent_p.I151I|ACO1_uc003zqx.3_Silent_p.I317I|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	317					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		AAGTTAGTATCACGTACCTGG	0.483													0	0	0	1	0	29	93										T	32421006	C	T	32421006	2	4	68	1	0	0	0	0	0	0	0	1	146	816	29	1		1	ACO1	9	32421006	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10446214	32421006	108792425	472	20992										
GALT	2592	broad.mit.edu	37	chr9	34647665	34647665	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttacctcaggacccagtgatCatccccttttccaagcaaag	6	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:34647665C>T	uc003zve.2	+	4	407	c.340C>T	c.(340-342)CAT>TAT	p.H114Y	GALT_uc003zvf.2_Intron|GALT_uc003zvg.2_5'UTR|GALT_uc003zvh.2_Missense_Mutation_p.H66Y|GALT_uc011lop.1_Missense_Mutation_p.H66Y	NM_000155	NP_000146	P07902	GALT_HUMAN	galactose-1-phosphate uridylyltransferase	114			H -> L (in GALCT).		galactose catabolic process	cytosol	UDP-glucose:hexose-1-phosphate uridylyltransferase activity|zinc ion binding				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		ACCCAGTGATCATCCCCTTTT	0.517									Galactosemia				0	0	0	1	0	6	31										T	34647665	C	T	34647665	3	4	68	1	0	0	0	0	1	0	0	0	6230	826	29	1	354	1	GALT	9	34647665	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2226659	34647665	106565766	473	20993										
KIAA1045	23349	broad.mit.edu	37	chr9	34971533	34971533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgccggccgcgcagcctggGagcggctccgagatgggcgc	19	14	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:34971533G>A	uc003zvq.2	+	2	416	c.238G>A	c.(238-240)GAG>AAG	p.E80K	KIAA1045_uc003zvr.2_Missense_Mutation_p.E80K	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	80							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			CGCAGCCTGGGAGCGGCTCCG	0.637													0	0	0	1	0	26	88										A	34971533	G	A	34971533	3	1	68	1	0	0	0	0	1	0	0	0	8207	1175	41	1	240	1	KIAA1045	9	34971533	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	323868	34971533	106241898	474	20994										
SPAG8	26206	broad.mit.edu	37	chr9	35811936	35811936	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgacctgggactgtcatctGaagaaggaaacggttccgaa	12	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:35811936G>A	uc003zye.2	-	2	222	c.107C>T	c.(106-108)TCA>TTA	p.S36L	SPAG8_uc003zyf.2_5'UTR|SPAG8_uc003zyg.2_Missense_Mutation_p.S36L	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	36						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			ACTGTCATCTGAAGAAGGAAA	0.388													0	0	0	1	0	10	37										A	35811936	G	A	35811936	3	1	68	1	0	0	0	0	1	0	0	0	14984	1294	45	1	1625	1	SPAG8	9	35811936	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	840403	35811936	105401495	475	20995										
FOXD4L3	286380	broad.mit.edu	37	chr9	70918850	70918850	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcatctctttcagcattgaGagtattatgcaaggggtcag	11	7	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:70918850G>C	uc004agm.1	+	1	1068	c.983G>C	c.(982-984)AGA>ACA	p.R328T		NM_199135	NP_954586	Q6VB84	FX4L3_HUMAN	forkhead box D4-like 3	328						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				all cancers(8;0.00136)|Epithelial(8;0.0288)|GBM - Glioblastoma multiforme(74;0.0402)|OV - Ovarian serous cystadenocarcinoma(323;0.18)		TCAGCATTGAGAGTATTATGC	0.632													0	0	0	1	0	20	96										C	70918850	G	C	70918850	3	2	68	1	0	0	0	0	1	0	0	0	6001	942	33	1	985	1	FOXD4L3	9	70918850	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	35106914	70918850	70294581	476	20996										
TJP2	9414	broad.mit.edu	37	chr9	71866215	71866215	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgggcaaagtcaaaatatttGagaagatggatcacaaggcc	11	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:71866215G>A	uc004ahe.2	+	21	3456	c.3256G>A	c.(3256-3258)GAG>AAG	p.E1086K	TJP2_uc011lrs.1_Intron|TJP2_uc004ahf.2_Intron|TJP2_uc011lru.1_Missense_Mutation_p.E1053K|TJP2_uc011lrv.1_Missense_Mutation_p.E1108K|TJP2_uc010mom.1_Intron	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	1086					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						CAAAATATTTGAGAAGATGGA	0.468													0	0	0	1	0	11	43										A	71866215	G	A	71866215	3	1	68	1	0	0	0	0	1	0	0	0	15927	1291	45	1	3597	1	TJP2	9	71866215	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	947365	71866215	69347216	477	20997										
HNRNPK	3190	broad.mit.edu	37	chr9	86586977	86586977	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcattctgtcaaaaccacctCttccccgcatgggaaatccc	6	16	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:86586977C>G	uc004ang.3	-	11	997	c.773G>C	c.(772-774)AGA>ACA	p.R258T	HNRNPK_uc011lsw.1_Missense_Mutation_p.R18T|HNRNPK_uc004and.3_Missense_Mutation_p.R18T|HNRNPK_uc004ank.3_Missense_Mutation_p.R258T|HNRNPK_uc004anf.3_Missense_Mutation_p.R258T|HNRNPK_uc004anh.3_Missense_Mutation_p.R234T|HNRNPK_uc011lsx.1_Missense_Mutation_p.R234T|HNRNPK_uc004ani.3_Missense_Mutation_p.R258T|HNRNPK_uc004anj.3_Missense_Mutation_p.R258T|HNRNPK_uc004ann.3_Missense_Mutation_p.R234T|HNRNPK_uc004anl.3_Missense_Mutation_p.R258T|HNRNPK_uc004anm.3_Missense_Mutation_p.R258T|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	258	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.|RNA-binding RGG-box.|2 X 6 AA approximate repeats.|Necessary for interaction with DDX1.|3-2.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						AAAACCACCTCTTCCCCGCAT	0.507													0	0	0	1	0	8	69										G	86586977	C	G	86586977	3	3	68	1	0	0	0	0	1	0	0	0	7269	913	32	1	684	1	HNRNPK	9	86586977	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	14720762	86586977	54626454	478	20998										
SLC28A3	64078	broad.mit.edu	37	chr9	86905100	86905100	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtatgcacctagcacgcttCcagcaatggtagagaacccg	10	12	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:86905100C>T	uc010mpz.2	-	11	1243	c.1118G>A	c.(1117-1119)GGA>GAA	p.G373E	SLC28A3_uc011lsy.1_Missense_Mutation_p.G304E|SLC28A3_uc004anu.1_Missense_Mutation_p.G373E	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	373	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TAGCACGCTTCCAGCAATGGT	0.428													0	0	0	1	0	14	61										T	86905100	C	T	86905100	3	4	68	1	0	0	0	0	1	0	0	0	14533	855	30	1	989	1	SLC28A3	9	86905100	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	318123	86905100	54308331	479	20999										
DAPK1	1612	broad.mit.edu	37	chr9	90252913	90252913	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaaaggaatctttaactgaaGaggaagcaactgaatttctc	8	6	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:90252913G>A	uc004apc.2	+	4	478	c.340G>A	c.(340-342)GAG>AAG	p.E114K	DAPK1_uc004ape.2_Missense_Mutation_p.E114K|DAPK1_uc004apd.2_Missense_Mutation_p.E114K|DAPK1_uc011ltg.1_Missense_Mutation_p.E114K|DAPK1_uc011lth.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	114	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TTTAACTGAAGAGGAAGCAAC	0.413									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	1	0	27	45										A	90252913	G	A	90252913	3	1	68	1	0	0	0	0	1	0	0	0	4235	943	33	1	350	1	DAPK1	9	90252913	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3347813	90252913	50960518	480	21000										
NOL8	55035	broad.mit.edu	37	chr9	95062233	95062233	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcctcttctgaactgctgtCttgtaaacgagggtcttcct	8	11	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:95062233C>T	uc004arv.2	-	14	3578	c.3241G>A	c.(3241-3243)GAC>AAC	p.D1081N	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Missense_Mutation_p.D313N|NOL8_uc011ltw.1_Missense_Mutation_p.D1013N	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	1081					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						GAACTGCTGTCTTGTAAACGA	0.398													0	0	0	1	0	47	216										T	95062233	C	T	95062233	3	4	68	1	0	0	0	0	1	0	0	0	10527	913	32	1	278	1	NOL8	9	95062233	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4809320	95062233	46151198	481	21001										
ZNF484	83744	broad.mit.edu	37	chr9	95618484	95618484	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgtgcttacccactgagatCaagttgaaatagttttccag	8	10	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:95618484C>G	uc004asu.1	-	3	281	c.132G>C	c.(130-132)TTG>TTC	p.L44F	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.L46F|ZNF484_uc010mrb.1_Missense_Mutation_p.L8F|ZNF484_uc004asv.1_Missense_Mutation_p.L8F	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCACTGAGATCAAGTTGAAAT	0.428													0	0	0	1	0	15	110										G	95618484	C	G	95618484	3	3	68	1	0	0	0	0	1	0	0	0	17934	825	29	1	2438	1	ZNF484	9	95618484	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	556251	95618484	45594947	482	21002										
KIAA1529	57653	broad.mit.edu	37	chr9	100071729	100071729	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actccctggcggccaccaggAagcgggctgcagagcgttct	14	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:100071729A>C	uc011lut.1	+	15	1425	c.652A>C	c.(652-654)AAG>CAG	p.K218Q	KIAA1529_uc004axe.1_Missense_Mutation_p.K218Q|KIAA1529_uc004axg.1_Missense_Mutation_p.K79Q|KIAA1529_uc011lus.1_Missense_Mutation_p.K79Q|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.K79Q|KIAA1529_uc011luv.1_Missense_Mutation_p.K79Q	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GGCCACCAGGAAGCGGGCTGC	0.602													0	0	0	1	0	9	48										C	100071729	A	C	100071729	3	2	68	1	0	0	0	0	1	0	0	0	8240	247	9	5	674	5	KIAA1529	9	100071729	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	4453245	100071729	41141702	483	21003										
TBC1D2	55357	broad.mit.edu	37	chr9	100963836	100963836	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agactgtccgcaaagaccacGaggaaccagttgaaggtgac	12	10	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:100963836G>A	uc011lvb.1	-	11	2562	c.2382C>T	c.(2380-2382)CTC>CTT	p.L794L	TBC1D2_uc004ayp.2_Silent_p.L334L|TBC1D2_uc004ayq.2_Silent_p.L794L|TBC1D2_uc004ayr.2_Silent_p.L576L|TBC1D2_uc004ayo.3_Silent_p.L794L	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	794	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CAAAGACCACGAGGAACCAGT	0.612													0	0	0	1	0	14	65										A	100963836	G	A	100963836	2	1	68	1	0	0	0	0	0	0	0	1	15605	1045	37	1		1	TBC1D2	9	100963836	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	892107	100963836	40249595	484	21004										
PPP3R2	5535	broad.mit.edu	37	chr9	104356723	104356723	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaccagcttcttgtggatctCcaggtctctgaccacagcac	9	14	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:104356723C>T	uc004bbr.2	-	1	561	c.490G>A	c.(490-492)GAG>AAG	p.E164K	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	161	EF-hand 4.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	TTGTGGATCTCCAGGTCTCTG	0.478													0	0	0	1	0	10	77										T	104356723	C	T	104356723	3	4	68	1	0	0	0	0	1	0	0	0	12401	864	30	1	35	1	PPP3R2	9	104356723	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3392887	104356723	36856708	485	21005										
GRIN3A	116443	broad.mit.edu	37	chr9	104433061	104433061	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agagtcattagtcatggggtCtagacagagttggccagcag	14	7	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:104433061C>G	uc004bbp.1	-	3	2234	c.1633G>C	c.(1633-1635)GAC>CAC	p.D545H	GRIN3A_uc004bbq.1_Missense_Mutation_p.D545H	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	545	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTCATGGGGTCTAGACAGAGT	0.463													0	0	0	1	0	22	77										G	104433061	C	G	104433061	3	3	68	1	0	0	0	0	1	0	0	0	6783	913	32	1	1742	1	GRIN3A	9	104433061	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	76338	104433061	36780370	486	21006										
CYLC2	1539	broad.mit.edu	37	chr9	105767661	105767661	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggatgaggatggaaaaaaaGatgcaaacaaaggtgatgaa	13	2	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:105767661G>A	uc004bbs.2	+	5	818	c.748G>A	c.(748-750)GAT>AAT	p.D250N		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	250	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				TGGAAAAAAAGATGCAAACAA	0.368													0	0	0	1	0	8	55										A	105767661	G	A	105767661	3	1	68	1	0	0	0	0	1	0	0	0	4142	942	33	1	766	1	CYLC2	9	105767661	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1334600	105767661	35445770	487	21007										
OR13C4	138804	broad.mit.edu	37	chr9	107288606	107288606	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctttatttctcaagctataGattatggggtttaacatggg	9	5	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:107288606G>A	uc011lvn.1	-	1	885	c.885C>T	c.(883-885)ATC>ATT	p.I295I		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	295	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCAAGCTATAGATTATGGGGT	0.403													0	0	0	1	0	14	76										A	107288606	G	A	107288606	2	1	68	1	0	0	0	0	0	0	0	1	10936	932	33	1		1	OR13C4	9	107288606	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1520945	107288606	33924825	488	21008										
ABCA1	19	broad.mit.edu	37	chr9	107564394	107564394	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcattaacttcttgactcgGaggaagtgcttgagtattac	9	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:107564394G>C	uc004bcl.2	-	34	4952	c.4639C>G	c.(4639-4641)CCG>GCG	p.P1547A		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1547	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCTTGACTCGGAGGAAGTGCT	0.423													0	0	0	1	0	11	49										C	107564394	G	C	107564394	3	2	68	1	0	0	0	0	1	0	0	0	28	1174	41	1	2214	1	ABCA1	9	107564394	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	275788	107564394	33649037	489	21009										
C9orf5	23731	broad.mit.edu	37	chr9	111798489	111798489	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctgtggcttacttaccctGatatgtcagagtagattgca	9	8	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:111798489G>A	uc004bdt.3	-	16	2428	c.2396C>T	c.(2395-2397)TCA>TTA	p.S799L	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Missense_Mutation_p.S791L	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	799						integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		TACTTACCCTGATATGTCAGA	0.373													0	0	0	1	0	5	38										A	111798489	G	A	111798489	3	1	68	1	0	0	0	0	1	0	0	0	2486	1294	45	1	255	1	C9orf5	9	111798489	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4234095	111798489	29414942	490	21010										
EPB41L4B	54566	broad.mit.edu	37	chr9	112020527	112020527	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atttggaatgaaccgaaactCagacacaagctctggtgtgt	10	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:112020527C>G	uc004bdz.1	-	7	977	c.682G>C	c.(682-684)GAG>CAG	p.E228Q	EPB41L4B_uc004bea.2_Missense_Mutation_p.E228Q	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	228	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						AACCGAAACTCAGACACAAGC	0.443													0	0	0	1	0	10	61										G	112020527	C	G	112020527	3	3	68	1	0	0	0	0	1	0	0	0	5156	835	29	1	2252	1	EPB41L4B	9	112020527	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	222038	112020527	29192904	491	21011										
PALM2	114299	broad.mit.edu	37	chr9	112705701	112705701	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtcaatgctgtgttgtcaTgtgaccacttctttcttctc	7	11	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:112705701T>C	uc004beg.2	+	7	1206	c.1136T>C	c.(1135-1137)ATG>ACG	p.M379T	PALM2_uc004bef.2_Missense_Mutation_p.M413T|PALM2_uc004beh.3_Missense_Mutation_p.M411T|PALM2-AKAP2_uc004bei.2_Intron|PALM2-AKAP2_uc004bek.3_Intron|PALM2-AKAP2_uc004bej.3_Intron|PALM2-AKAP2_uc004bel.1_Intron	NM_001037293	NP_001032370	Q8IXS6	PALM2_HUMAN	paralemmin 2 isoform b	379					regulation of cell shape	plasma membrane				ovary(2)	2						TGTGTTGTCATGTGACCACTT	0.512													0	0	0	1	0	17	81										C	112705701	T	C	112705701	3	2	68	1	0	0	0	0	1	0	0	0	11409	1464	51	5	1268	5	PALM2	9	112705701	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	685174	112705701	28507730	492	21012										
HDHD3	81932	broad.mit.edu	37	chr9	116136283	116136283	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcactccctcagggtgtcctCagccccatccaacacctgcc	7	20	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:116136283C>G	uc004bhi.1	-	2	1136	c.352G>C	c.(352-354)GAG>CAG	p.E118Q	HDHD3_uc004bhj.2_Missense_Mutation_p.E118Q|HDHD3_uc004bhk.2_Missense_Mutation_p.E118Q	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	118							phosphoglycolate phosphatase activity|protein binding				0						AGGGTGTCCTCAGCCCCATCC	0.627													0	0	0	1	0	35	132										G	116136283	C	G	116136283	3	3	68	1	0	0	0	0	1	0	0	0	7024	835	29	1	407	1	HDHD3	9	116136283	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3430582	116136283	25077148	493	21013										
DFNB31	25861	broad.mit.edu	37	chr9	117188609	117188609	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cactgtcaggatgaggtgccGagatgacttaagcagcctga	13	9	1	4	rs142990800	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:117188609G>A	uc004biz.3	-	4	1697	c.1048C>T	c.(1048-1050)CGG>TGG	p.R350W	DFNB31_uc004bix.2_5'Flank|DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Missense_Mutation_p.R350W	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	350	PDZ 2.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						ATGAGGTGCCGAGATGACTTA	0.587													0	0	0	1	0	9	54										A	117188609	G	A	117188609	3	1	68	1	0	0	0	0	1	0	0	0	4455	1057	37	1	1711	1	DFNB31	9	117188609	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1052326	117188609	24024822	494	21014										
TNC	3371	broad.mit.edu	37	chr9	117826296	117826296	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagtccagttgagtttgaggGcatcccagcccacctcggcc	11	15	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:117826296G>A	uc004bjj.3	-	12	3901	c.3539C>T	c.(3538-3540)GCC>GTC	p.A1180V	TNC_uc010mvf.2_Missense_Mutation_p.A1180V	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1180	Fibronectin type-III 7.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GAGTTTGAGGGCATCCCAGCC	0.522													0	0	0	1	0	45	152										A	117826296	G	A	117826296	3	1	68	1	0	0	0	0	1	0	0	0	16267	1203	42	2	3134	2	TNC	9	117826296	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	637687	117826296	23387135	495	21015										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123182069	123182069	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aatgaggcttagcttaccttGagaaaaactgttcaccataa	7	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:123182069G>C	uc004bkf.2	-	27	4355	c.4174C>G	c.(4174-4176)CAA>GAA	p.Q1392E	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.Q401E|CDK5RAP2_uc004bke.2_Missense_Mutation_p.Q677E|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.Q1392E|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.Q657E|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.Q657E|CDK5RAP2_uc011lya.1_Missense_Mutation_p.Q657E|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.Q1162E|CDK5RAP2_uc004bki.2_Missense_Mutation_p.Q1159E	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1392					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						AGCTTACCTTGAGAAAAACTG	0.373													0	0	0	1	0	16	96										C	123182069	G	C	123182069	3	2	68	1	0	0	0	0	1	0	0	0	3146	1299	45	1	1555	1	CDK5RAP2	9	123182069	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5355773	123182069	18031362	496	21016										
DAB2IP	153090	broad.mit.edu	37	chr9	124519389	124519389	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggacctcagcatggaggaaGaggtggtcatcaagcccgtg	15	9	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:124519389G>C	uc004bln.2	+	4	445	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	DAB2IP_uc004blo.2_Missense_Mutation_p.E30Q	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	154	PH.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CATGGAGGAAGAGGTGGTCAT	0.637													0	0	0	1	0	12	37										C	124519389	G	C	124519389	3	2	68	1	0	0	0	0	1	0	0	0	4219	943	33	1	390	1	DAB2IP	9	124519389	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1337320	124519389	16694042	497	21017										
FAM102A	399665	broad.mit.edu	37	chr9	130705511	130705511	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggctcgtagaccccagaaGagaccctgcaggtgagagac	13	12	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:130705511G>C	uc004bsx.1	-	11	1194	c.1115C>G	c.(1114-1116)TCT>TGT	p.S372C	FAM102A_uc004bsw.1_Missense_Mutation_p.S230C|FAM102A_uc004bsy.1_3'UTR	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	372										ovary(1)	1						GACCCCAGAAGAGACCCTGCA	0.542											OREG0019513	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	64										C	130705511	G	C	130705511	3	2	68	1	0	0	0	0	1	0	0	0	5382	942	33	1	43	1	FAM102A	9	130705511	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6186122	130705511	10507920	498	21018										
ZER1	10444	broad.mit.edu	37	chr9	131497667	131497667	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcccagtgctggctgacagGagagattccctggggaagga	16	9	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:131497667G>C	uc004bwa.1	-	14	2519	c.2086C>G	c.(2086-2088)CCT>GCT	p.P696A		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	696					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TGGCTGACAGGAGAGATTCCC	0.532													0	0	0	1	0	4	28										C	131497667	G	C	131497667	3	2	68	1	0	0	0	0	1	0	0	0	17622	1174	41	1	226	1	ZER1	9	131497667	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	792156	131497667	9715764	499	21019										
POMT1	10585	broad.mit.edu	37	chr9	134381829	134381829	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcaattttttgtggaacaGaattggagcaggtaaaagat	12	3	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:134381829G>C	uc004cav.2	+	4	471	c.269G>C	c.(268-270)AGA>ACA	p.R90T	POMT1_uc011mci.1_Missense_Mutation_p.R90T|POMT1_uc004cax.2_Missense_Mutation_p.R90T|POMT1_uc011mcj.1_Missense_Mutation_p.E8Q|POMT1_uc004cau.2_Missense_Mutation_p.R90T|POMT1_uc004caw.2_Missense_Mutation_p.R36T|POMT1_uc011mck.1_5'UTR|POMT1_uc011mcl.1_5'UTR|POMT1_uc011mcm.1_Missense_Mutation_p.Q54H	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	90					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TTGTGGAACAGAATTGGAGCA	0.294													0	0	0	1	0	37	146										C	134381829	G	C	134381829	3	2	68	1	0	0	0	0	1	0	0	0	12245	942	33	1	279	1	POMT1	9	134381829	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2884162	134381829	6831602	500	21020										
CEL	1056	broad.mit.edu	37	chr9	135940563	135940563	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgcggaaacgtcatcgtggtCaccttcaactaccgtgtcgg	11	13	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:135940563C>T	uc010naa.1	+	4	502	c.486C>T	c.(484-486)GTC>GTT	p.V162V		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	159					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		TCATCGTGGTCACCTTCAACT	0.642													0	0	0	1	0	42	201										T	135940563	C	T	135940563	2	4	68	1	0	0	0	0	0	0	0	1	3209	813	29	1		1	CEL	9	135940563	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1558734	135940563	5272868	501	21021										
CEL	1056	broad.mit.edu	37	chr9	135947125	135947125	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagatgactccaaggaagctCagatgcctgcagtcattagg	11	10	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:135947125C>T	uc010naa.1	+	11	2261	c.2245C>T	c.(2245-2247)CAG>TAG	p.Q749*		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	746					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CAAGGAAGCTCAGATGCCTGC	0.647													0	0	0	1	0	5	38										T	135947125	C	T	135947125	4	4	68	1	0	0	0	0	0	1	0	0	3209	827	29	1	2287	1	CEL	9	135947125	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6562	135947125	5266306	502	21022										
ADAMTS13	11093	broad.mit.edu	37	chr9	136324273	136324273	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taccggagatgcaggaccctCagtcctggaagggaaaggaa	14	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:136324273C>T	uc004cdv.3	+	29	4699	c.4255C>T	c.(4255-4257)CAG>TAG	p.Q1419*	ADAMTS13_uc004cdp.3_3'UTR|ADAMTS13_uc004cdt.1_Nonsense_Mutation_p.Q1363*|ADAMTS13_uc004cdu.1_Nonsense_Mutation_p.Q1332*|ADAMTS13_uc004cdw.3_Nonsense_Mutation_p.Q1363*|ADAMTS13_uc004cdx.3_Nonsense_Mutation_p.Q1332*|ADAMTS13_uc004cdz.3_Nonsense_Mutation_p.Q1089*|ADAMTS13_uc004ceb.3_Nonsense_Mutation_p.Q215*|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1419	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GCAGGACCCTCAGTCCTGGAA	0.587													0	0	0	1	0	7	15										T	136324273	C	T	136324273	4	4	68	1	0	0	0	0	0	1	0	0	258	827	29	1	4369	1	ADAMTS13	9	136324273	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	377148	136324273	4889158	503	21023										
COL5A1	1289	broad.mit.edu	37	chr9	137704502	137704502	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctccggagctccaggtgctGatggcccacaaggtccccca	11	17	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:137704502G>A	uc004cfe.2	+	48	4178	c.3796G>A	c.(3796-3798)GAT>AAT	p.D1266N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1266	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TCCAGGTGCTGATGGCCCACA	0.622													0	0	0	1	0	6	7										A	137704502	G	A	137704502	3	1	68	1	0	0	0	0	1	0	0	0	3696	1290	45	1	3986	1	COL5A1	9	137704502	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1380229	137704502	3508929	504	21024										
LHX3	8022	broad.mit.edu	37	chr9	139090634	139090634	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccggcgtccttcttcagcctCttctccttggcccggcggtt	10	17	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:139090634C>T	uc004cha.2	-	5	736	c.639G>A	c.(637-639)AAG>AAA	p.K213K	LHX3_uc004cgz.2_Silent_p.K218K	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	213	Homeobox.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		TCTTCAGCCTCTTCTCCTTGG	0.721													0	0	0	1	0	7	24										T	139090634	C	T	139090634	2	4	68	1	0	0	0	0	0	0	0	1	8772	912	32	1		1	LHX3	9	139090634	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1386132	139090634	2122797	505	21025										
FBXW5	54461	broad.mit.edu	37	chr9	139836636	139836636	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttggtctctagcatgcgctCcgacagctgtggctgcgccc	12	15	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:139836636C>G	uc004cjx.2	-	6	1109	c.958G>C	c.(958-960)GAG>CAG	p.E320Q	FBXW5_uc010nbx.2_RNA|FBXW5_uc004cjy.2_Missense_Mutation_p.E68Q|FBXW5_uc004cjz.2_Missense_Mutation_p.E68Q	NM_018998	NP_061871	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	320							catalytic activity|protein binding				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		AGCATGCGCTCCGACAGCTGT	0.697													0	0	0	1	0	4	5										G	139836636	C	G	139836636	3	3	68	1	0	0	0	0	1	0	0	0	5768	864	30	1	758	1	FBXW5	9	139836636	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	746002	139836636	1376795	506	21026										
MAN1B1	11253	broad.mit.edu	37	chr9	139982608	139982608	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttttctgtggactcctcttcTacatcaacttggctgaccat	6	12	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr9:139982608T>A	uc004cld.2	+	2	336	c.301T>A	c.(301-303)TAC>AAC	p.Y101N	MAN1B1_uc004clc.2_5'UTR|MAN1B1_uc011meo.1_5'UTR|MAN1B1_uc011mep.1_Missense_Mutation_p.Y101N|MAN1B1_uc010ncc.2_RNA|LOC100289341_uc004clb.3_5'Flank	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	101	Helical; Signal-anchor for type II membrane protein; (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		ACTCCTCTTCTACATCAACTT	0.438													0	0	0	1	0	17	118										A	139982608	T	A	139982608	3	1	68	1	0	0	0	0	1	0	0	0	9212	1522	53	5	307	5	MAN1B1	9	139982608	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	145972	139982608	1230823	507	21027										
AKR1E2	83592	broad.mit.edu	37	chr10	4877927	4877927	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttctgcctctcacatcctCgagtgcaggacttgcctctg	8	16	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:4877927C>G	uc001ihi.2	+	4	500	c.385C>G	c.(385-387)CGA>GGA	p.R129G	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Missense_Mutation_p.R90G|AKR1E2_uc001ihh.1_Missense_Mutation_p.R129G|AKR1E2_uc009xhw.2_Missense_Mutation_p.R129G|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Missense_Mutation_p.R129G	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	129						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						CTCACATCCTCGAGTGCAGGA	0.517													0	0	0	1	0	18	59										G	4877927	C	G	4877927	3	3	68	1	0	0	0	0	1	0	0	0	474	876	31	1	399	1	AKR1E2	10	4877927	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		4877927	130656820	508	21028										
PRKCQ	5588	broad.mit.edu	37	chr10	6540507	6540507	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttccgtctcaaattcattCatgtcctttgtgtctacagg	6	12	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:6540507C>A	uc001ijj.1	-	5	468	c.393G>T	c.(391-393)ATG>ATT	p.M131I	PRKCQ_uc009xim.1_Missense_Mutation_p.M131I|PRKCQ_uc001iji.1_Missense_Mutation_p.M164I|PRKCQ_uc009xin.1_Missense_Mutation_p.M95I|PRKCQ_uc010qax.1_Missense_Mutation_p.M6I	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	131					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						CAAATTCATTCATGTCCTTTG	0.527													1	0	3.52763e-06	1	3.72263e-06	18	30										A	6540507	C	A	6540507	3	1	68	1	0	0	0	0	1	0	0	0	12515	826	29	3	1783	3	PRKCQ	10	6540507	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1662580	6540507	128994240	509	21029										
BEND7	222389	broad.mit.edu	37	chr10	13534731	13534731	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accaccgactttttctccatCtctgacccactgggcttctg	6	16	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:13534731C>G	uc001imm.2	-	5	858	c.561G>C	c.(559-561)GAG>GAC	p.E187D	BEND7_uc001imo.3_Missense_Mutation_p.E200D	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	239							protein binding			ovary(1)|breast(1)	2						TTTTCTCCATCTCTGACCCAC	0.532													0	0	0	1	0	24	186										G	13534731	C	G	13534731	3	3	68	1	0	0	0	0	1	0	0	0	1403	912	32	1	877	1	BEND7	10	13534731	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6994224	13534731	122000016	510	21030										
CACNB2	783	broad.mit.edu	37	chr10	18690931	18690931	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accgggaggcagtgcgcagaGaagcggagcggcaggcccag	19	11	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:18690931G>C	uc001ipr.2	+	3	352	c.292G>C	c.(292-294)GAA>CAA	p.E98Q	CACNB2_uc009xjz.1_Missense_Mutation_p.E98Q|CACNB2_uc001ips.2_Missense_Mutation_p.E98Q|CACNB2_uc001ipt.2_Missense_Mutation_p.E98Q|CACNB2_uc010qcl.1_RNA|CACNB2_uc001ipu.2_Missense_Mutation_p.E70Q|CACNB2_uc001ipv.2_Missense_Mutation_p.E70Q|CACNB2_uc009xka.1_Missense_Mutation_p.E70Q|CACNB2_uc001ipw.2_Missense_Mutation_p.E43Q|CACNB2_uc001ipx.2_Missense_Mutation_p.E43Q|CACNB2_uc009xkb.1_Missense_Mutation_p.E44Q|CACNB2_uc010qcm.1_Missense_Mutation_p.E44Q|CACNB2_uc001ipz.2_Missense_Mutation_p.E44Q|CACNB2_uc001ipy.2_Missense_Mutation_p.E44Q|CACNB2_uc010qcn.1_Missense_Mutation_p.E50Q|CACNB2_uc010qco.1_Missense_Mutation_p.E50Q|CACNB2_uc001iqa.2_Missense_Mutation_p.E50Q	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	98					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AGTGCGCAGAGAAGCGGAGCG	0.542													0	0	0	1	0	6	71										C	18690931	G	C	18690931	3	2	68	1	0	0	0	0	1	0	0	0	2553	943	33	1	522	1	CACNB2	10	18690931	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5156200	18690931	116843816	511	21031										
ANKRD26	22852	broad.mit.edu	37	chr10	27318254	27318254	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttctcagcacatctgacaGcttctgtatgtcgatcctgt	7	12	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:27318254G>C	uc001ith.2	-	26	4008	c.3836C>G	c.(3835-3837)GCT>GGT	p.A1279G	ANKRD26_uc001itg.2_Missense_Mutation_p.A966G|ANKRD26_uc009xku.1_Missense_Mutation_p.A1280G	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1279	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						ACATCTGACAGCTTCTGTATG	0.308													0	0	0	1	0	10	27										C	27318254	G	C	27318254	3	2	68	1	0	0	0	0	1	0	0	0	654	971	34	4	1329	4	ANKRD26	10	27318254	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8627323	27318254	108216493	512	21032										
SYT15	83849	broad.mit.edu	37	chr10	46963916	46963916	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggcatcggccttgaagctGaaggtctcattgtacacagg	13	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:46963916G>A	uc001jea.2	-	7	1200	c.1047C>T	c.(1045-1047)TTC>TTT	p.F349F	SYT15_uc001jdz.2_Silent_p.F349F|SYT15_uc001jeb.2_Silent_p.F227F|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	349	Cytoplasmic (Potential).|C2 2.					integral to membrane|plasma membrane					0						CCTTGAAGCTGAAGGTCTCAT	0.532													0	0	0	1	0	6	48										A	46963916	G	A	46963916	2	1	68	1	0	0	0	0	0	0	0	1	15468	1281	45	1		1	SYT15	10	46963916	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	19645662	46963916	88570831	513	21033										
GDF10	2662	broad.mit.edu	37	chr10	48429210	48429210	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgggtccctctcctcagaatCcagctgggcggagaggagca	14	13	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:48429210C>A	uc001jfb.2	-	2	1132	c.676G>T	c.(676-678)GAT>TAT	p.D226Y	GDF10_uc009xnp.2_Missense_Mutation_p.D225Y|GDF10_uc009xnq.1_Missense_Mutation_p.D226Y	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	226					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						TCCTCAGAATCCAGCTGGGCG	0.697													1	0	1	1	1	3	12										A	48429210	C	A	48429210	3	1	68	1	0	0	0	0	1	0	0	0	6311	855	30	3	768	3	GDF10	10	48429210	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1465294	48429210	87105537	514	21034										
JMJD1C	221037	broad.mit.edu	37	chr10	64937590	64937590	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttaaaatgtcatccaaatCttcttcctcaaatttcttga	2	11	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:64937590C>T	uc001jmn.2	-	23	7411	c.7111G>A	c.(7111-7113)GAT>AAT	p.D2371N	JMJD1C_uc001jml.2_Missense_Mutation_p.D2134N|JMJD1C_uc001jmm.2_Missense_Mutation_p.D2083N|JMJD1C_uc010qiq.1_Missense_Mutation_p.D2189N|JMJD1C_uc009xpi.2_Missense_Mutation_p.D2189N|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmk.2_5'Flank|JMJD1C_uc001jmo.2_Missense_Mutation_p.D278N	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2371	JmjC.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TCATCCAAATCTTCTTCCTCA	0.363													0	0	0	1	0	5	16										T	64937590	C	T	64937590	3	4	68	1	0	0	0	0	1	0	0	0	7950	913	32	1	527	1	JMJD1C	10	64937590	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	16508380	64937590	70597157	515	21035										
SIRT1	23411	broad.mit.edu	37	chr10	69672284	69672284	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttaatagagaacctttgcctCatctgcattttgatgtagag	8	7	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:69672284C>T	uc001jnd.2	+	8	1464	c.1411C>T	c.(1411-1413)CAT>TAT	p.H471Y	SIRT1_uc010qis.1_Missense_Mutation_p.H176Y|SIRT1_uc009xpp.2_Missense_Mutation_p.H279Y|SIRT1_uc001jne.2_Missense_Mutation_p.H168Y	NM_012238	NP_036370	Q96EB6	SIRT1_HUMAN	sirtuin 1 isoform a	471	Deacetylase sirtuin-type.				apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0						ACCTTTGCCTCATCTGCATTT	0.378													0	0	0	1	0	30	33										T	69672284	C	T	69672284	3	4	68	1	0	0	0	0	1	0	0	0	14337	826	29	1	1441	1	SIRT1	10	69672284	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4734694	69672284	65862463	516	21036										
DDX50	79009	broad.mit.edu	37	chr10	70670973	70670973	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaagactccaaagaaatcaaGaaacaattaaaaaaagccgc	5	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:70670973G>C	uc001jou.2	+	4	717	c.610G>C	c.(610-612)GAA>CAA	p.E204Q	DDX50_uc001jot.2_Missense_Mutation_p.E204Q|DDX50_uc010qjc.1_Missense_Mutation_p.E204Q	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	204	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						AAGAAATCAAGAAACAATTAA	0.368													0	0	0	1	0	17	83										C	70670973	G	C	70670973	3	2	68	1	0	0	0	0	1	0	0	0	4368	943	33	1	624	1	DDX50	10	70670973	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	998689	70670973	64863774	517	21037										
PPP3CB	5532	broad.mit.edu	37	chr10	75239090	75239090	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttacctgtgattggagcttCtacttctatcatggttttct	7	9	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:75239090C>G	uc001jue.2	-	2	406	c.271G>C	c.(271-273)GAA>CAA	p.E91Q	PPP3CB_uc001juf.2_Missense_Mutation_p.E91Q|PPP3CB_uc001jug.2_Missense_Mutation_p.E91Q|PPP3CB_uc001jui.2_Missense_Mutation_p.E91Q|PPP3CB_uc001juh.2_Missense_Mutation_p.E5Q	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	91	Catalytic.									skin(1)	1	Prostate(51;0.0119)					ATTGGAGCTTCTACTTCTATC	0.368													0	0	0	1	0	40	134										G	75239090	C	G	75239090	3	3	68	1	0	0	0	0	1	0	0	0	12398	922	32	1	1358	1	PPP3CB	10	75239090	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4568117	75239090	60295657	518	21038										
POLR3A	11128	broad.mit.edu	37	chr10	79781696	79781696	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggggaatgcccgagagctCactgttaatgtagagggcac	15	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:79781696C>G	uc001jzn.2	-	7	1064	c.970G>C	c.(970-972)GAG>CAG	p.E324Q		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	324					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CCCGAGAGCTCACTGTTAATG	0.542													0	0	0	1	0	5	47										G	79781696	C	G	79781696	3	3	68	1	0	0	0	0	1	0	0	0	12228	835	29	1	3302	1	POLR3A	10	79781696	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4542606	79781696	55753051	519	21039										
LIPJ	142910	broad.mit.edu	37	chr10	90356673	90356673	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtttatgatgtttggatatGacccaaaaaacttaaatatg	7	4	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:90356673G>T	uc001kff.2	+	8	1017	c.703G>T	c.(703-705)GAC>TAC	p.D235Y		NM_001010939	NP_001010939	Q5W064	LIPJ_HUMAN	lipase, family member J	235					lipid catabolic process		hydrolase activity			ovary(1)	1		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		GTTTGGATATGACCCAAAAAA	0.274													1	0	1.15088e-07	1	1.23835e-07	17	81										T	90356673	G	T	90356673	3	4	68	1	0	0	0	0	1	0	0	0	8826	1290	45	3	725	3	LIPJ	10	90356673	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10574977	90356673	45178074	520	21040										
PANK1	53354	broad.mit.edu	37	chr10	91353615	91353615	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggccaaatcgttcatagtctCctccgtaaatgtccttcacc	6	14	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:91353615C>T	uc001kgp.1	-	4	1598	c.1442G>A	c.(1441-1443)GGA>GAA	p.G481E	PANK1_uc001kgn.1_Missense_Mutation_p.G256E|PANK1_uc001kgo.1_Intron|PANK1_uc009xtu.1_Missense_Mutation_p.G283E|uc001kgq.1_5'Flank|MIR107_hsa-mir-107|MI0000114_5'Flank	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	481					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	TTCATAGTCTCCTCCGTAAAT	0.463													0	0	0	1	0	72	159										T	91353615	C	T	91353615	3	4	68	1	0	0	0	0	1	0	0	0	11416	855	30	1	370	1	PANK1	10	91353615	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	996942	91353615	44181132	521	21041										
CEP55	55165	broad.mit.edu	37	chr10	95266787	95266787	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actcatcaataaataatattCatgaaatggaaatacagctg	5	6	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:95266787C>G	uc009xug.2	+	4	684	c.502C>G	c.(502-504)CAT>GAT	p.H168D	CEP55_uc001kiq.3_Missense_Mutation_p.H168D	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	168	Interaction with PDCD6IP.|Potential.|Interaction with TSG101.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				AAATAATATTCATGAAATGGA	0.318													0	0	0	1	0	13	46										G	95266787	C	G	95266787	3	3	68	1	0	0	0	0	1	0	0	0	3255	826	29	1	512	1	CEP55	10	95266787	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3913172	95266787	40267960	522	21042										
RRP12	23223	broad.mit.edu	37	chr10	99125901	99125901	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcctccatcttgttgccgtCtgcctcctcccttatgatca	5	16	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:99125901C>T	uc001knf.2	-	29	3620	c.3481G>A	c.(3481-3483)GAC>AAC	p.D1161N	RRP12_uc001kne.2_Missense_Mutation_p.D176N|RRP12_uc009xvl.2_Missense_Mutation_p.D278N|RRP12_uc009xvm.2_Missense_Mutation_p.D879N|RRP12_uc010qou.1_Missense_Mutation_p.D1100N|RRP12_uc009xvn.2_Missense_Mutation_p.D1061N	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1161						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TTGTTGCCGTCTGCCTCCTCC	0.597													0	0	0	1	0	27	74										T	99125901	C	T	99125901	3	4	68	1	0	0	0	0	1	0	0	0	13686	913	32	1	436	1	RRP12	10	99125901	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3859114	99125901	36408846	523	21043										
BLOC1S2	282991	broad.mit.edu	37	chr10	102045915	102045915	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgtcccggcagagctcagtGatgtcagcttcagcaggctc	12	12	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:102045915G>A	uc001kqw.1	-	2	134	c.111C>T	c.(109-111)ATC>ATT	p.I37I	BLOC1S2_uc001kqv.1_5'UTR	NM_173809	NP_776170	Q6QNY1	BL1S2_HUMAN	biogenesis of lysosome-related organelles	37					melanosome organization|microtubule nucleation|platelet dense granule organization|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of apoptosis	BLOC-1 complex|centrosome|gamma-tubulin complex|nucleus	gamma-tubulin binding|identical protein binding|protein C-terminus binding			ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.44e-10)|all cancers(201;1.97e-08)		AGAGCTCAGTGATGTCAGCTT	0.602													0	0	0	1	0	17	62										A	102045915	G	A	102045915	2	1	68	1	0	0	0	0	0	0	0	1	1449	1280	45	1		1	BLOC1S2	10	102045915	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2920014	102045915	33488832	524	21044										
GBF1	8729	broad.mit.edu	37	chr10	104129979	104129979	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaagcaagttcctccagctgGagtcactacaggagctcatg	10	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:104129979G>C	uc001kux.1	+	27	3625	c.3385G>C	c.(3385-3387)GAG>CAG	p.E1129Q	GBF1_uc001kuy.1_Missense_Mutation_p.E1129Q|GBF1_uc001kuz.1_Missense_Mutation_p.E1130Q	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1129					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CCTCCAGCTGGAGTCACTACA	0.463													0	0	0	1	0	94	114										C	104129979	G	C	104129979	3	2	68	1	0	0	0	0	1	0	0	0	6271	1175	41	1	3487	1	GBF1	10	104129979	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2084064	104129979	31404768	525	21045										
CALHM2	51063	broad.mit.edu	37	chr10	105207100	105207100	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaagttggcaatcagttcctCatcatccttgttgagcgcca	9	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:105207100C>T	uc001kwz.2	-	3	1167	c.781G>A	c.(781-783)GAG>AAG	p.E261K	CALHM2_uc001kxa.2_Missense_Mutation_p.E261K|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Missense_Mutation_p.E261K	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	261						integral to membrane				skin(1)	1						ATCAGTTCCTCATCATCCTTG	0.607													0	0	0	1	0	13	67										T	105207100	C	T	105207100	3	4	68	1	0	0	0	0	1	0	0	0	2583	835	29	1	194	1	CALHM2	10	105207100	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1077121	105207100	30327647	526	21046										
C10orf82	143379	broad.mit.edu	37	chr10	118425186	118425186	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggaccgtctcctcggagttGacaggtttcagtttcggggc	14	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:118425186G>C	uc001lcr.2	-	3	262	c.207C>G	c.(205-207)GTC>GTG	p.V69V	C10orf82_uc001lcs.1_Silent_p.V69V	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	69											0				all cancers(201;0.0143)		CCTCGGAGTTGACAGGTTTCA	0.567													0	0	0	1	0	9	42										C	118425186	G	C	118425186	2	2	68	1	0	0	0	0	0	0	0	1	1620	1277	45	1		1	C10orf82	10	118425186	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	13218086	118425186	17109561	527	21047										
WDR11	55717	broad.mit.edu	37	chr10	122622425	122622425	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaaattttaatcactcaagaGaaacctaggtaagttacaag	6	6	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:122622425G>A	uc010qtf.1	+	5	943	c.705G>A	c.(703-705)GAG>GAA	p.E235E	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	235						integral to membrane					0						TCACTCAAGAGAAACCTAGGT	0.368													0	0	0	1	0	25	39										A	122622425	G	A	122622425	2	1	68	1	0	0	0	0	0	0	0	1	17270	933	33	1		1	WDR11	10	122622425	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4197239	122622425	12912322	528	21048										
C10orf90	118611	broad.mit.edu	37	chr10	128193522	128193522	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agccagagattgcttggcgtGatgtgcacgagactgagcaa	14	8	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:128193522G>T	uc001ljq.2	-	3	368	c.247C>A	c.(247-249)CAC>AAC	p.H83N	C10orf90_uc001ljp.2_Missense_Mutation_p.H36N|C10orf90_uc010qum.1_Missense_Mutation_p.H180N|C10orf90_uc009yao.2_Missense_Mutation_p.H180N|C10orf90_uc001ljs.1_Missense_Mutation_p.H36N	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	83										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TGCTTGGCGTGATGTGCACGA	0.517													1	0	5.60225e-13	1	6.33079e-13	28	81										T	128193522	G	T	128193522	3	4	68	1	0	0	0	0	1	0	0	0	1623	1290	45	3	1880	3	C10orf90	10	128193522	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5571097	128193522	7341225	529	21049										
MKI67	4288	broad.mit.edu	37	chr10	129913840	129913840	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtctccccctgtaaaccatCagcactttctttctctgttg	6	14	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:129913840C>G	uc001lke.2	-	7	1027	c.832G>C	c.(832-834)GAT>CAT	p.D278H	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	278					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGTAAACCATCAGCACTTTCT	0.448													0	0	0	1	0	17	32										G	129913840	C	G	129913840	3	3	68	1	0	0	0	0	1	0	0	0	9598	826	29	1	8974	1	MKI67	10	129913840	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1720318	129913840	5620907	530	21050										
GPR123	84435	broad.mit.edu	37	chr10	134942263	134942263	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccaccactgcgccaagcgtGaggacgtgtggcagtgctgg	15	12	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr10:134942263G>A	uc001llx.3	+	7	1367	c.931G>A	c.(931-933)GAG>AAG	p.E311K	GPR123_uc001llw.2_Missense_Mutation_p.E1030K	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CGCCAAGCGTGAGGACGTGTG	0.692													0	0	0	1	0	9	18										A	134942263	G	A	134942263	3	1	68	1	0	0	0	0	1	0	0	0	6637	1291	45	1	953	1	GPR123	10	134942263	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5028423	134942263	592484	531	21051										
RNH1	6050	broad.mit.edu	37	chr11	498609	498609	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccccgcagcccttggcagtGatgccacactcccagatcct	8	18	0	2	rs139771148	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:498609G>A	uc001lpk.1	-	6	2212	c.804C>T	c.(802-804)ATC>ATT	p.I268I	RNH1_uc001lpl.1_Silent_p.I268I|RNH1_uc001lpm.1_Silent_p.I268I|RNH1_uc001lpn.1_Silent_p.I268I|RNH1_uc001lpo.1_Silent_p.I268I|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Silent_p.I268I|RNH1_uc001lpt.1_Silent_p.I25I|RNH1_uc001lpq.1_Silent_p.I268I|RNH1_uc001lpr.1_Silent_p.I268I|RNH1_uc001lps.1_Silent_p.I268I	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	268	LRR 9.				mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCTTGGCAGTGATGCCACACT	0.647													0	0	0	1	0	34	45										A	498609	G	A	498609	2	1	68	1	0	0	0	0	0	0	0	1	13504	1280	45	1		1	RNH1	11	498609	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		498609	134507907	532	21052										
MUC6	4588	broad.mit.edu	37	chr11	1028259	1028259	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catggagcaggggtcagtctCacgctccagagcggccggac	15	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:1028259C>G	uc001lsw.2	-	14	1771	c.1720G>C	c.(1720-1722)GAG>CAG	p.E574Q		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	574	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGTCAGTCTCACGCTCCAGA	0.662													0	0	0	1	0	4	7										G	1028259	C	G	1028259	3	3	68	1	0	0	0	0	1	0	0	0	9980	835	29	1	5679	1	MUC6	11	1028259	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	529650	1028259	133978257	533	21053										
CTSD	1509	broad.mit.edu	37	chr11	1775286	1775286	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcgcgcacctcatccaccgGgcccaccatgagggaagtgc	11	17	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:1775286G>C	uc001luc.1	-	7	1043	c.910C>G	c.(910-912)CCG>GCG	p.P304A	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	304					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCATCCACCGGGCCCACCATG	0.602													0	0	0	1	0	6	22										C	1775286	G	C	1775286	3	2	68	1	0	0	0	0	1	0	0	0	4032	1232	43	4	340	4	CTSD	11	1775286	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	747027	1775286	133231230	534	21054										
TNNI2	7136	broad.mit.edu	37	chr11	1862395	1862395	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacaaggtgtgcatggacctGagggccaacctgaagcaggt	14	10	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:1862395G>C	uc010qxe.1	+	5	433	c.411G>C	c.(409-411)CTG>CTC	p.L137L	TNNI2_uc010qxc.1_Silent_p.L135L|TNNI2_uc010qxd.1_Silent_p.L135L	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	137					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCATGGACCTGAGGGCCAACC	0.652													0	0	0	1	0	16	24										C	1862395	G	C	1862395	2	2	68	1	0	0	0	0	0	0	0	1	16324	1277	45	1		1	TNNI2	11	1862395	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	87109	1862395	133144121	535	21055										
TRPM5	29850	broad.mit.edu	37	chr11	2432724	2432724	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taggccacgagccacacgctCagaaagaagaggaagaagaa	12	9	1	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:2432724C>A	uc001lwm.3	-	18	2649	c.2640G>T	c.(2638-2640)CTG>CTT	p.L880L	TRPM5_uc010qxl.1_Silent_p.L880L|TRPM5_uc009ydn.2_Silent_p.L882L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	880	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCCACACGCTCAGAAAGAAGA	0.672													1	0	0.000566183	1	0.000583312	15	68										A	2432724	C	A	2432724	2	1	68	1	0	0	0	0	0	0	0	1	16586	813	29	3		3	TRPM5	11	2432724	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	570329	2432724	132573792	536	21056										
OR51V1	283111	broad.mit.edu	37	chr11	5221178	5221178	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggacagcacagatgtgggaGatgcaggtctgaaataattt	13	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:5221178G>A	uc010qyz.1	-	1	753	c.753C>T	c.(751-753)ATC>ATT	p.I251I		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGATGTGGGAGATGCAGGTCT	0.483													0	0	0	1	0	22	52										A	5221178	G	A	5221178	2	1	68	1	0	0	0	0	0	0	0	1	11107	932	33	1		1	OR51V1	11	5221178	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2788454	5221178	129785338	537	21057										
ZNF214	7761	broad.mit.edu	37	chr11	7021665	7021665	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaagcctttaccacagtcttCacatttataagacttctctc	3	12	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:7021665C>G	uc001mfa.2	-	3	1552	c.1249G>C	c.(1249-1251)GAA>CAA	p.E417Q	ZNF214_uc010ray.1_Missense_Mutation_p.E417Q|ZNF214_uc009yfh.1_Missense_Mutation_p.E417Q	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	417	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		CCACAGTCTTCACATTTATAA	0.398													0	0	0	1	0	54	79										G	7021665	C	G	7021665	3	3	68	1	0	0	0	0	1	0	0	0	17767	835	29	1	575	1	ZNF214	11	7021665	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1800487	7021665	127984851	538	21058										
ADM	133	broad.mit.edu	37	chr11	10327968	10327968	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagctttggctgccgcttcgGgacgtgcacggtgcagaagc	16	11	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:10327968G>A	uc001mik.1	+	3	955	c.338G>A	c.(337-339)GGG>GAG	p.G113E	ADM_uc001mil.1_Missense_Mutation_p.G113E|ADM_uc001mim.1_Missense_Mutation_p.G66E	NM_001124	NP_001115	P35318	ADML_HUMAN	adrenomedullin precursor	113					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)	1				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		TGCCGCTTCGGGACGTGCACG	0.632													0	0	0	1	0	10	33										A	10327968	G	A	10327968	3	1	68	1	0	0	0	0	1	0	0	0	321	1232	43	2	348	2	ADM	11	10327968	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3306303	10327968	124678548	539	21059										
PIK3C2A	5286	broad.mit.edu	37	chr11	17139154	17139154	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttttcctcctactgacaggaGagcacccaaaacatgttcgt	7	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:17139154G>C	uc001mmq.3	-	18	3166	c.3100C>G	c.(3100-3102)CTC>GTC	p.L1034V	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.L654V|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1034					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	ACTGACAGGAGAGCACCCAAA	0.413													0	0	0	1	0	14	61										C	17139154	G	C	17139154	3	2	68	1	0	0	0	0	1	0	0	0	11909	942	33	1	2020	1	PIK3C2A	11	17139154	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6811186	17139154	117867362	540	21060										
ANO3	63982	broad.mit.edu	37	chr11	26463525	26463525	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttaaaaccgtctcggagatCcctgccttgcctcgcccaga	9	15	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:26463525C>T	uc001mqt.3	+	2	252	c.107C>T	c.(106-108)TCC>TTC	p.S36F	ANO3_uc010rdr.1_Missense_Mutation_p.S20F	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	36	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTCGGAGATCCCTGCCTTGC	0.438													0	0	0	1	0	29	127										T	26463525	C	T	26463525	3	4	68	1	0	0	0	0	1	0	0	0	698	855	30	1	113	1	ANO3	11	26463525	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9324371	26463525	108542991	541	21061										
CCDC34	91057	broad.mit.edu	37	chr11	27378991	27378991	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccggtcacgttcttctttttCtttgccaataaaccacacct	4	14	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:27378991C>T	uc001mrh.1	-	2	511	c.457G>A	c.(457-459)GAA>AAA	p.E153K	CCDC34_uc001mri.1_Missense_Mutation_p.E153K	NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	153	Potential.										0						TCTTCTTTTTCTTTGCCAATA	0.433													0	0	0	1	0	16	92										T	27378991	C	T	27378991	3	4	68	1	0	0	0	0	1	0	0	0	2807	922	32	1	768	1	CCDC34	11	27378991	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	915466	27378991	107627525	542	21062										
ABTB2	25841	broad.mit.edu	37	chr11	34189480	34189480	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagtttgccccagcatcaatCaacatctggaccatcgcttc	6	14	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:34189480C>A	uc001mvl.1	-	6	1295	c.1065G>T	c.(1063-1065)CTG>CTT	p.L355L		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	355							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CAGCATCAATCAACATCTGGA	0.562													1	0	0.004672	1	0.00473971	3	16										A	34189480	C	A	34189480	2	1	68	1	0	0	0	0	0	0	0	1	103	825	29	3		3	ABTB2	11	34189480	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6810489	34189480	100817036	543	21063										
LDLRAD3	143458	broad.mit.edu	37	chr11	36248961	36248961	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctccccaccctcctactccGaggccttgctggaccagagg	10	18	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:36248961G>T	uc001mwk.1	+	5	818	c.781G>T	c.(781-783)GAG>TAG	p.E261*	LDLRAD3_uc010rey.1_Nonsense_Mutation_p.E212*|LDLRAD3_uc010rez.1_Nonsense_Mutation_p.E140*|LDLRAD3_uc010rfa.1_Intron	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	261	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				CTCCTACTCCGAGGCCTTGCT	0.577													1	0	0.000442599	1	0.000456363	10	97										T	36248961	G	T	36248961	4	4	68	1	0	0	0	0	0	1	0	0	8707	1059	37	3	799	3	LDLRAD3	11	36248961	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2059481	36248961	98757555	544	21064										
OR4X1	390113	broad.mit.edu	37	chr11	48285748	48285748	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtggcactgaggcctttctCctgatggtgatggcctatga	14	9	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:48285748C>G	uc010rht.1	+	1	336	c.336C>G	c.(334-336)CTC>CTG	p.L112L		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						AGGCCTTTCTCCTGATGGTGA	0.493													0	0	0	1	0	9	56										G	48285748	C	G	48285748	2	3	68	1	0	0	0	0	0	0	0	1	11084	842	30	1		1	OR4X1	11	48285748	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	12036787	48285748	86720768	545	21065										
OR5D18	219438	broad.mit.edu	37	chr11	55587800	55587800	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catcctcaagatgcgttcagTcagtgggcgccgcaaagcct	11	13	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:55587800T>C	uc010rin.1	+	1	695	c.695T>C	c.(694-696)GTC>GCC	p.V232A		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				ATGCGTTCAGTCAGTGGGCGC	0.498													0	0	0	1	0	16	105										C	55587800	T	C	55587800	3	2	68	1	0	0	0	0	1	0	0	0	11157	1667	58	5	697	5	OR5D18	11	55587800	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	7302052	55587800	79418716	546	21066										
OR5AS1	219447	broad.mit.edu	37	chr11	55798344	55798344	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcattgtgttggcatatttCagtggaagtacaacatcact	8	7	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:55798344C>T	uc010riw.1	+	1	450	c.450C>T	c.(448-450)TTC>TTT	p.F150F		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TGGCATATTTCAGTGGAAGTA	0.453													0	0	0	1	0	17	235										T	55798344	C	T	55798344	2	4	68	1	0	0	0	0	0	0	0	1	11146	825	29	1		1	OR5AS1	11	55798344	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	210544	55798344	79208172	547	21067										
OR5M10	390167	broad.mit.edu	37	chr11	56345151	56345152	+	Missense_Mutation	DNP	CC	CC	TT													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcactgggtcgtctgtcagtCctaagagaatgaattctgtc							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:56345151_56345152CC>TT	uc001niz.1	-	1	46_47	c.46_47GG>AA	c.(46-48)GGA>AAA	p.G16K		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCTGTCAGTCCTAAGAGAATG	0.455													0	0	0	1	0	29	74										TT	56345152	CC	TT	56345151	3	4	68	1	0	0	0	0	1	0	0	0	11173	855	30	1	904	1	OR5M10	11	56345151	Missense_Mutation	DNP	CC	TCGA-DK-A3X1-01A-12D-A22Z-08	546807	56345151	78661365	548	21068										
SSRP1	6749	broad.mit.edu	37	chr11	57099862	57099862	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagggagacactcactcgttCatgttcagagtcaacgaaat	9	10	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:57099862C>T	uc001njt.2	-	7	1134	c.867G>A	c.(865-867)ATG>ATA	p.M289I		NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	289					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						CTCACTCGTTCATGTTCAGAG	0.522													0	0	0	1	0	26	129										T	57099862	C	T	57099862	3	4	68	1	0	0	0	0	1	0	0	0	15193	826	29	1	1306	1	SSRP1	11	57099862	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	754711	57099862	77906654	549	21069										
CNTF	1270	broad.mit.edu	37	chr11	58391557	58391557	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacctggactctgcggatggGatgccagtggcaagcactga	14	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:58391557G>A	uc001nna.3	+	2	245	c.165G>A	c.(163-165)GGG>GGA	p.G55G	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	55					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				CTGCGGATGGGATGCCAGTGG	0.527													0	0	0	1	0	11	75										A	58391557	G	A	58391557	2	1	68	1	0	0	0	0	0	0	0	1	3637	1161	41	1		1	CNTF	11	58391557	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1291695	58391557	76614959	550	21070										
CNTF	1270	broad.mit.edu	37	chr11	58391595	58391595	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgatcagtggagtgagctgaCcgaggcagagcgactccaag	15	9	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:58391595C>A	uc001nna.3	+	2	283	c.203C>A	c.(202-204)ACC>AAC	p.T68N	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	68					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AGTGAGCTGACCGAGGCAGAG	0.537													1	0	2.27111e-07	1	2.43748e-07	13	68										A	58391595	C	A	58391595	3	1	68	1	0	0	0	0	1	0	0	0	3637	507	18	4	209	4	CNTF	11	58391595	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	38	58391595	76614921	551	21071										
OR5AN1	390195	broad.mit.edu	37	chr11	59132261	59132261	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcttttcaacgatgggactGagtgagtcttgtctcatgac	10	8	4	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:59132261G>C	uc010rks.1	+	1	330	c.330G>C	c.(328-330)CTG>CTC	p.L110L		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CGATGGGACTGAGTGAGTCTT	0.443													0	0	0	1	0	19	194										C	59132261	G	C	59132261	2	2	68	1	0	0	0	0	0	0	0	1	11143	1277	45	1		1	OR5AN1	11	59132261	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	740666	59132261	75874255	552	21072										
OR5A1	219982	broad.mit.edu	37	chr11	59211279	59211279	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtcactgtcggaggaacatCgttcctccaactccttatct	8	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:59211279C>T	uc001nnx.1	+	1	638	c.638C>T	c.(637-639)TCG>TTG	p.S213L		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GGAGGAACATCGTTCCTCCAA	0.542													0	0	0	1	0	39	215										T	59211279	C	T	59211279	3	4	68	1	0	0	0	0	1	0	0	0	11139	893	31	1	640	1	OR5A1	11	59211279	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	79018	59211279	75795237	553	21073										
PGA5	5222	broad.mit.edu	37	chr11	61017253	61017253	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccattgccaacatccagagcGacatcggagccagcgagaac	10	14	0	2	rs139795742		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:61017253G>T	uc001nqz.2	+	7	916	c.886G>T	c.(886-888)GAC>TAC	p.D296Y		NM_014224	NP_055039	P00790	PEPA_HUMAN	pepsinogen 5, group I precursor	296					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			skin(1)	1						CATCCAGAGCGACATCGGAGC	0.612													1	0	6.48837e-15	1	7.37181e-15	41	196										T	61017253	G	T	61017253	3	4	68	1	0	0	0	0	1	0	0	0	11772	1058	37	3	912	3	PGA5	11	61017253	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1805974	61017253	73989263	554	21074										
C11orf9	745	broad.mit.edu	37	chr11	61548506	61548506	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctaccaggcatacagccctCtttgctgctgggtgcgtgtc	12	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:61548506C>G	uc001nsc.1	+	20	2657	c.2561C>G	c.(2560-2562)TCT>TGT	p.S854C	C11orf9_uc001nse.1_Missense_Mutation_p.S819C|C11orf9_uc010rll.1_Missense_Mutation_p.S245C	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	854					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						ATACAGCCCTCTTTGCTGCTG	0.617													0	0	0	1	0	10	44										G	61548506	C	G	61548506	3	3	68	1	0	0	0	0	1	0	0	0	1671	913	32	1	2665	1	C11orf9	11	61548506	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	531253	61548506	73458010	555	21075										
FADS2	9415	broad.mit.edu	37	chr11	61624491	61624491	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctctcctcagtacggcaaGaagaagctgaaatacctgcc	8	13	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:61624491G>C	uc001nsl.1	+	6	903	c.753G>C	c.(751-753)AAG>AAC	p.K251N	FADS2_uc001nsj.2_Missense_Mutation_p.K229N|FADS2_uc010rlo.1_Missense_Mutation_p.K220N|FADS2_uc001nsk.2_Missense_Mutation_p.K251N	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	251	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	AGTACGGCAAGAAGAAGCTGA	0.577													0	0	0	1	0	13	71										C	61624491	G	C	61624491	3	2	68	1	0	0	0	0	1	0	0	0	5366	933	33	1	775	1	FADS2	11	61624491	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	75985	61624491	73382025	556	21076										
FADS3	3995	broad.mit.edu	37	chr11	61646279	61646279	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accaggacttcttgaagatgGaggcatggcccaggtcatgc	13	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:61646279G>C	uc001nsm.2	-	4	716	c.563C>G	c.(562-564)TCC>TGC	p.S188C	FADS3_uc001nsn.2_Missense_Mutation_p.S64C	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	188	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						CTTGAAGATGGAGGCATGGCC	0.642													0	0	0	1	0	7	44										C	61646279	G	C	61646279	3	2	68	1	0	0	0	0	1	0	0	0	5367	1174	41	1	810	1	FADS3	11	61646279	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	21788	61646279	73360237	557	21077										
GANAB	23193	broad.mit.edu	37	chr11	62402467	62402467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctcatcacgaccagagacaGaaagcctgggaaacatatca	8	11	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:62402467G>C	uc001nub.2	-	5	419	c.386C>G	c.(385-387)TCT>TGT	p.S129C	GANAB_uc001nua.2_Missense_Mutation_p.S129C|GANAB_uc001nuc.2_Missense_Mutation_p.S32C|GANAB_uc010rma.1_Missense_Mutation_p.S15C|GANAB_uc010rmb.1_Missense_Mutation_p.S15C	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	129					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						ACCAGAGACAGAAAGCCTGGG	0.463													0	0	0	1	0	16	76										C	62402467	G	C	62402467	3	2	68	1	0	0	0	0	1	0	0	0	6233	942	33	1	2598	1	GANAB	11	62402467	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	756188	62402467	72604049	558	21078										
SLC22A8	9376	broad.mit.edu	37	chr11	62763271	62763271	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttggccaaggagatctccttCtgcaggttgagtttgagctc	12	9	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:62763271C>T	uc001nwo.2	-	7	1042	c.906G>A	c.(904-906)CAG>CAA	p.Q302Q	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Silent_p.Q302Q|SLC22A8_uc009yom.2_Silent_p.Q179Q|SLC22A8_uc010rmm.1_Silent_p.Q211Q|SLC22A8_uc009yon.2_Silent_p.Q302Q	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	302	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						AGATCTCCTTCTGCAGGTTGA	0.587													0	0	0	1	0	22	84										T	62763271	C	T	62763271	2	4	68	1	0	0	0	0	0	0	0	1	14460	912	32	1		1	SLC22A8	11	62763271	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	360804	62763271	72243245	559	21079										
RTN3	10313	broad.mit.edu	37	chr11	63520106	63520106	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctggtagaagatctggttGactccttgaaggttagttgt	12	5	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:63520106G>C	uc001nxq.2	+	5	3053	c.2866G>C	c.(2866-2868)GAC>CAC	p.D956H	RTN3_uc001nxo.2_Missense_Mutation_p.D160H|RTN3_uc001nxm.2_Missense_Mutation_p.D179H|RTN3_uc001nxn.2_Missense_Mutation_p.D937H|RTN3_uc001nxp.2_Missense_Mutation_p.D160H|RTN3_uc009yov.2_Missense_Mutation_p.D844H|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	956	Helical; (Potential).|Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						AGATCTGGTTGACTCCTTGAA	0.413													0	0	0	1	0	36	144										C	63520106	G	C	63520106	3	2	68	1	0	0	0	0	1	0	0	0	13727	1290	45	1	2884	1	RTN3	11	63520106	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	756835	63520106	71486410	560	21080										
C11orf84	144097	broad.mit.edu	37	chr11	63594565	63594565	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccacagttctgtcagaatCcagcaccactgtggcaggga	11	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:63594565C>A	uc001nxt.2	+	6	1336	c.1100C>A	c.(1099-1101)TCC>TAC	p.S367Y	C11orf84_uc001nxu.1_RNA	NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	367											0						CTGTCAGAATCCAGCACCACT	0.612													1	0	0.000157383	1	0.00016281	8	33										A	63594565	C	A	63594565	3	1	68	1	0	0	0	0	1	0	0	0	1667	855	30	3	1122	3	C11orf84	11	63594565	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	74459	63594565	71411951	561	21081										
PLCB3	5331	broad.mit.edu	37	chr11	64033997	64033997	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagattaaccgtcggcacatCactgagtcagtcaactccat	8	12	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:64033997C>T	uc001nzb.2	+	29	3387	c.3387C>T	c.(3385-3387)ATC>ATT	p.I1129I	PLCB3_uc009ypg.1_Silent_p.I1129I|PLCB3_uc009yph.1_Silent_p.I1062I|PLCB3_uc009ypi.2_Silent_p.I1129I	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1129					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GTCGGCACATCACTGAGTCAG	0.632													0	0	0	1	0	16	36										T	64033997	C	T	64033997	2	4	68	1	0	0	0	0	0	0	0	1	12029	816	29	1		1	PLCB3	11	64033997	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	439432	64033997	70972519	562	21082										
MEN1	4221	broad.mit.edu	37	chr11	64573830	64573830	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccgatagtaggtcttggctGaggcaatgccctggatggag	15	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:64573830G>A	uc001obj.2	-	7	1011	c.938C>T	c.(937-939)TCA>TTA	p.S313L	MEN1_uc001obk.2_Missense_Mutation_p.S313L|MEN1_uc001obl.2_Missense_Mutation_p.S273L|MEN1_uc001obm.2_Missense_Mutation_p.S308L|MEN1_uc001obn.2_Missense_Mutation_p.S313L|MEN1_uc001obo.2_Missense_Mutation_p.S313L|MEN1_uc001obp.2_Missense_Mutation_p.S308L|MEN1_uc001obq.2_Missense_Mutation_p.S313L|MEN1_uc001obr.2_Missense_Mutation_p.S313L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	313	Interaction with FANCD2.				DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						GGTCTTGGCTGAGGCAATGCC	0.622			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1		OREG0004014	type=REGULATORY REGION|Gene=MEN1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	1	0	42	78										A	64573830	G	A	64573830	3	1	68	1	0	0	0	0	1	0	0	0	9472	1294	45	1	925	1	MEN1	11	64573830	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	539833	64573830	70432686	563	21083										
LTBP3	4054	broad.mit.edu	37	chr11	65325173	65325173	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgagcgtcatgttggagccCtgctgacaactgtcccgaca	11	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:65325173C>G	uc001oej.2	-	1	527	c.258G>C	c.(256-258)CAG>CAC	p.Q86H	LTBP3_uc010roi.1_5'UTR|LTBP3_uc001oei.2_Missense_Mutation_p.Q86H|LTBP3_uc010roj.1_Missense_Mutation_p.Q72H|LTBP3_uc010rok.1_5'UTR	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	86	Gly-rich.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						TGTTGGAGCCCTGCTGACAAC	0.647													0	0	0	1	0	6	71										G	65325173	C	G	65325173	3	3	68	1	0	0	0	0	1	0	0	0	9075	680	24	4	3765	4	LTBP3	11	65325173	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	751343	65325173	69681343	564	21084										
PACS1	55690	broad.mit.edu	37	chr11	65998061	65998061	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttggagatgccagcacgagtCtggttgtgccggagaaagtc	15	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:65998061C>G	uc001oha.1	+	12	1551	c.1417C>G	c.(1417-1419)CTG>GTG	p.L473V	PACS1_uc010rou.1_Missense_Mutation_p.L9V	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	473					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						CAGCACGAGTCTGGTTGTGCC	0.542													0	0	0	1	0	9	52										G	65998061	C	G	65998061	3	3	68	1	0	0	0	0	1	0	0	0	11372	912	32	1	1463	1	PACS1	11	65998061	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	672888	65998061	69008455	565	21085										
RBM4B	83759	broad.mit.edu	37	chr11	66444533	66444533	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcctcccggggaaggtttccGatgaacagcttcaccatcct	10	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:66444533G>A	uc001oja.2	-	1	687	c.18C>T	c.(16-18)ATC>ATT	p.I6I	RBM4B_uc001ojb.2_Silent_p.I6I	NM_031492	NP_113680	Q9BQ04	RBM4B_HUMAN	RNA binding motif protein 4B	6	RRM 1.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|RNA splicing	nucleolus	nucleotide binding|RNA binding|zinc ion binding				0						GAAGGTTTCCGATGAACAGCT	0.502													0	0	0	1	0	21	139										A	66444533	G	A	66444533	2	1	68	1	0	0	0	0	0	0	0	1	13142	1048	37	1		1	RBM4B	11	66444533	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	446472	66444533	68561983	566	21086										
SPTBN2	6712	broad.mit.edu	37	chr11	66466202	66466202	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtatgcaggttgcgggcctCgtcataggacacgtcctggg	15	10	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:66466202C>T	uc001ojd.2	-	19	3994	c.3922G>A	c.(3922-3924)GAG>AAG	p.E1308K		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1308	Spectrin 10.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TTGCGGGCCTCGTCATAGGAC	0.562													0	0	0	1	0	12	69										T	66466202	C	T	66466202	3	4	68	1	0	0	0	0	1	0	0	0	15119	893	31	1	3326	1	SPTBN2	11	66466202	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	21669	66466202	68540314	567	21087										
LRFN4	78999	broad.mit.edu	37	chr11	66627177	66627177	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcgctgactatgacctctgCctgctggccttgtcaccggc	12	15	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:66627177C>A	uc001ojr.2	+	2	1759	c.1419C>A	c.(1417-1419)TGC>TGA	p.C473*	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	473	Extracellular (Potential).|Fibronectin type-III.					integral to membrane					0						ATGACCTCTGCCTGCTGGCCT	0.687													1	0	1.12685e-05	1	1.18122e-05	8	20										A	66627177	C	A	66627177	4	1	68	1	0	0	0	0	0	1	0	0	8940	747	26	4	1425	4	LRFN4	11	66627177	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	160975	66627177	68379339	568	21088			1	94		4	4	235	C		7.78811e-08
LRFN4	78999	broad.mit.edu	37	chr11	66627252	66627252	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgggctgtgcccatttctcCacgctgccggcctcgcccct	10	19	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:66627252C>A	uc001ojr.2	+	2	1834	c.1494C>A	c.(1492-1494)TCC>TCA	p.S498S	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	498	Extracellular (Potential).					integral to membrane					0						CCCATTTCTCCACGCTGCCGG	0.716													1	0	0.00116845	1	0.00119403	6	12										A	66627252	C	A	66627252	2	1	68	1	0	0	0	0	0	0	0	1	8940	581	21	4		4	LRFN4	11	66627252	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	75	66627252	68379264	569	21089			1	94		4	4	235	C		7.78811e-08
LRFN4	78999	broad.mit.edu	37	chr11	66627354	66627354	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggtggctgccttactggtCttcactgtggccttgctggt	13	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:66627354C>G	uc001ojr.2	+	2	1936	c.1596C>G	c.(1594-1596)GTC>GTG	p.V532V	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	532	Helical; (Potential).					integral to membrane					0						CCTTACTGGTCTTCACTGTGG	0.721													0	0	0	1	0	9	25										G	66627354	C	G	66627354	2	3	68	1	0	0	0	0	0	0	0	1	8940	900	32	1		1	LRFN4	11	66627354	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	102	66627354	68379162	570	21090			1	94		4	4	235	C		7.78811e-08
LRFN4	78999	broad.mit.edu	37	chr11	66627411	66627411	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggaaatggccgcctccccctCaagctcagccacgtccagtc	9	18	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:66627411C>G	uc001ojr.2	+	2	1993	c.1653C>G	c.(1651-1653)CTC>CTG	p.L551L	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	551	Cytoplasmic (Potential).					integral to membrane					0						GCCTCCCCCTCAAGCTCAGCC	0.587													0	0	0	1	0	10	19										G	66627411	C	G	66627411	2	3	68	1	0	0	0	0	0	0	0	1	8940	813	29	1		1	LRFN4	11	66627411	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	57	66627411	68379105	571	21091			1	94		4	4	235	C		7.78811e-08
NDUFV1	4723	broad.mit.edu	37	chr11	67377958	67377958	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggggctggggcctacatctGtggagaggagacagcgctca	17	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:67377958G>C	uc001omj.2	+	5	770	c.617G>C	c.(616-618)TGT>TCT	p.C206S	NDUFV1_uc010rpv.1_Missense_Mutation_p.C105S|NDUFV1_uc001oml.2_Missense_Mutation_p.C199S|NDUFV1_uc001omk.3_Missense_Mutation_p.C197S|NDUFV1_uc009yrz.1_Missense_Mutation_p.C105S|NDUFV1_uc010rpw.1_5'Flank	NM_007103	NP_009034	P49821	NDUV1_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 1	206	FMN (By similarity).				mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	GCCTACATCTGTGGAGAGGAG	0.602													0	0	0	1	0	44	106										C	67377958	G	C	67377958	3	2	68	1	0	0	0	0	1	0	0	0	10299	1377	48	4	635	4	NDUFV1	11	67377958	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	750547	67377958	67628558	572	21092										
KRTAP5-7	440050	broad.mit.edu	37	chr11	71238672	71238672	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgctcctcaggctgtgggtCatcctgctgccagtccagct	11	15	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:71238672C>G	uc001oqq.1	+	1	360	c.326C>G	c.(325-327)TCA>TGA	p.S109*		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	109	7 X 4 AA repeats of C-C-X-P.					keratin filament					0						ggctgtgggtcatcctgctgc	0.139													0	0	0	1	0	71	198										G	71238672	C	G	71238672	4	3	68	1	0	0	0	0	0	1	0	0	8566	838	29	1	328	1	KRTAP5-7	11	71238672	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3860714	71238672	63767844	573	21093										
NUMA1	4926	broad.mit.edu	37	chr11	71726869	71726869	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aactgctgctccttctgcttCaggctactgcttagctgctc	8	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:71726869C>G	uc001orl.1	-	15	1852	c.1680G>C	c.(1678-1680)CTG>CTC	p.L560L	NUMA1_uc009ysw.1_Silent_p.L123L|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Silent_p.L560L|NUMA1_uc001orn.2_Silent_p.L123L|NUMA1_uc009ysx.1_Silent_p.L560L|NUMA1_uc001oro.1_Silent_p.L560L	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	560	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCTTCTGCTTCAGGCTACTGC	0.612			T	RARA	APL						OREG0021187	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	26	150										G	71726869	C	G	71726869	2	3	68	1	0	0	0	0	0	0	0	1	10750	813	29	1		1	NUMA1	11	71726869	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	488197	71726869	63279647	574	21094										
STARD10	10809	broad.mit.edu	37	chr11	72466776	72466776	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggaactgagaagatttattCaccacccacttgggtaagga	10	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:72466776C>T	uc001osy.2	-	6	891	c.600G>A	c.(598-600)GTG>GTA	p.V200V	ARAP1_uc001osv.2_Intron|STARD10_uc001osz.3_Silent_p.V200V|STARD10_uc001ota.2_Silent_p.V154V|STARD10_uc001otb.2_Silent_p.V200V	NM_006645	NP_006636	Q9Y365	PCTL_HUMAN	START domain containing 10	200	START.										0			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			AAGATTTATTCACCACCCACT	0.592													0	0	0	1	0	13	35										T	72466776	C	T	72466776	2	4	68	1	0	0	0	0	0	0	0	1	15254	813	29	1		1	STARD10	11	72466776	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	739907	72466776	62539740	575	21095										
UCP2	7351	broad.mit.edu	37	chr11	73686631	73686631	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agggcagagttcatgtatctCgtcttgaccacgtctacagg	11	10	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:73686631C>T	uc001oup.1	-	7	1100	c.720G>A	c.(718-720)ACG>ACA	p.T240T	UCP2_uc001ouq.1_Intron	NM_003355	NP_003346	P55851	UCP2_HUMAN	uncoupling protein 2	240	Solcar 3.				proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)					TCATGTATCTCGTCTTGACCA	0.592													0	0	0	1	0	31	101										T	73686631	C	T	73686631	2	4	68	1	0	0	0	0	0	0	0	1	16928	871	31	1		1	UCP2	11	73686631	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1219855	73686631	61319885	576	21096										
CAPN5	726	broad.mit.edu	37	chr11	76825378	76825378	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtttctgagcccatcgacctGaccgagggtgactttgccaa	11	12	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:76825378G>C	uc001oxx.2	+	5	782	c.597G>C	c.(595-597)CTG>CTC	p.L199L	CAPN5_uc009yup.2_Silent_p.L239L|CAPN5_uc009yuq.2_Silent_p.L235L|CAPN5_uc001oxy.2_Silent_p.L239L	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	199	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						CCATCGACCTGACCGAGGGTG	0.582											OREG0021255	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	44	309										C	76825378	G	C	76825378	2	2	68	1	0	0	0	0	0	0	0	1	2629	1277	45	1		1	CAPN5	11	76825378	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3138747	76825378	58181138	577	21097										
MYO7A	4647	broad.mit.edu	37	chr11	76869381	76869381	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggagtacgccaacatccgctCcgccatgaaggtgctcatgt	11	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:76869381C>T	uc001oyb.2	+	9	1180	c.908C>T	c.(907-909)TCC>TTC	p.S303F	MYO7A_uc010rsl.1_Missense_Mutation_p.S303F|MYO7A_uc010rsm.1_Missense_Mutation_p.S292F|MYO7A_uc001oyc.2_Missense_Mutation_p.S303F	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	303	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						AACATCCGCTCCGCCATGAAG	0.607													0	0	0	1	0	12	33										T	76869381	C	T	76869381	3	4	68	1	0	0	0	0	1	0	0	0	10082	855	30	1	938	1	MYO7A	11	76869381	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	44003	76869381	58137135	578	21098										
AQP11	282679	broad.mit.edu	37	chr11	77301476	77301476	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcttgggtctgacccagtatCacgtcagcgagaggagcttc	13	11	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:77301476C>T	uc001oyj.2	+	1	797	c.439C>T	c.(439-441)CAC>TAC	p.H147Y	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	147						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GACCCAGTATCACGTCAGCGA	0.592													0	0	0	1	0	30	54										T	77301476	C	T	77301476	3	4	68	1	0	0	0	0	1	0	0	0	823	826	29	1	441	1	AQP11	11	77301476	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	432095	77301476	57705040	579	21099										
NARS2	79731	broad.mit.edu	37	chr11	78270590	78270590	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggaagcaaaacttacttcaaGttgaaaaagttctccagctc	7	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:78270590G>C	uc001ozi.2	-	5	965	c.589C>G	c.(589-591)CTT>GTT	p.L197V	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	197					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	CTTACTTCAAGTTGAAAAAGT	0.353													0	0	0	1	0	26	142										C	78270590	G	C	78270590	3	2	68	1	0	0	0	0	1	0	0	0	10171	1029	36	4	884	4	NARS2	11	78270590	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	969114	78270590	56735926	580	21100										
ODZ4	26011	broad.mit.edu	37	chr11	78433937	78433937	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgctgagacacaaactggttCtccccattccctttgtgcag	8	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:78433937C>G	uc001ozl.3	-	24	4039	c.3576G>C	c.(3574-3576)GAG>GAC	p.E1192D		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1192	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CAAACTGGTTCTCCCCATTCC	0.552													0	0	0	1	0	24	33										G	78433937	C	G	78433937	3	3	68	1	0	0	0	0	1	0	0	0	10837	912	32	1	4777	1	ODZ4	11	78433937	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	163347	78433937	56572579	581	21101										
NAALAD2	10003	broad.mit.edu	37	chr11	89885637	89885637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggtgacccactcactccaGgctatccagcaaaaggtaag	9	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:89885637G>A	uc001pdf.3	+	6	890	c.781G>A	c.(781-783)GGC>AGC	p.G261S	NAALAD2_uc009yvx.2_Missense_Mutation_p.G261S|NAALAD2_uc009yvy.2_Missense_Mutation_p.G261S|NAALAD2_uc001pdd.2_Missense_Mutation_p.G261S|NAALAD2_uc001pde.2_Missense_Mutation_p.G261S	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	261	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ACTCACTCCAGGCTATCCAGC	0.448													0	0	0	1	0	16	33										A	89885637	G	A	89885637	3	1	68	1	0	0	0	0	1	0	0	0	10128	1000	35	2	803	2	NAALAD2	11	89885637	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11451700	89885637	45120879	582	21102										
CCDC67	159989	broad.mit.edu	37	chr11	93097339	93097339	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttacagttttccaaactaaCaaataactttgaaaaactga	3	7	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:93097339C>G	uc001pdq.2	+	5	411	c.311C>G	c.(310-312)ACA>AGA	p.T104R	CCDC67_uc001pdo.1_Missense_Mutation_p.T104R|CCDC67_uc001pdp.2_Missense_Mutation_p.T104R	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	104	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TCCAAACTAACAAATAACTTT	0.303													0	0	0	1	0	5	25										G	93097339	C	G	93097339	3	3	68	1	0	0	0	0	1	0	0	0	2839	478	17	4	325	4	CCDC67	11	93097339	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3211702	93097339	41909177	583	21103										
PIWIL4	143689	broad.mit.edu	37	chr11	94328539	94328539	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggctgaaaagacacgtctCagtccttcaggccggcagca	12	12	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:94328539C>G	uc001pfa.2	+	10	1426	c.1215C>G	c.(1213-1215)CTC>CTG	p.L405L	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	405					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGACACGTCTCAGTCCTTCAG	0.502													0	0	0	1	0	19	116										G	94328539	C	G	94328539	2	3	68	1	0	0	0	0	0	0	0	1	11960	813	29	1		1	PIWIL4	11	94328539	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1231200	94328539	40677977	584	21104										
JRKL	8690	broad.mit.edu	37	chr11	96124003	96124003	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagttctgattccacaagtCttttggccaagaggaaatct	9	9	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:96124003C>G	uc009ywu.2	+	2	442	c.190C>G	c.(190-192)CTT>GTT	p.L64V	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Missense_Mutation_p.L64V	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	64					central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		TTCCACAAGTCTTTTGGCCAA	0.398													0	0	0	1	0	18	104										G	96124003	C	G	96124003	3	3	68	1	0	0	0	0	1	0	0	0	7965	913	32	1	192	1	JRKL	11	96124003	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1795464	96124003	38882513	585	21105										
CNTN5	53942	broad.mit.edu	37	chr11	99827554	99827554	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagagatcatctatagctgGgtatttaatgagttcccttc	8	8	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:99827554G>T	uc001pga.2	+	8	1029	c.690G>T	c.(688-690)TGG>TGT	p.W230C	CNTN5_uc009ywv.1_Missense_Mutation_p.W230C|CNTN5_uc001pfz.2_Missense_Mutation_p.W230C|CNTN5_uc001pgb.2_Missense_Mutation_p.W156C	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	230	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCTATAGCTGGGTATTTAATG	0.393													1	0	8.00594e-06	1	8.41325e-06	19	48										T	99827554	G	T	99827554	3	4	68	1	0	0	0	0	1	0	0	0	3644	1241	43	4	712	4	CNTN5	11	99827554	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3703551	99827554	35178962	586	21106										
YAP1	10413	broad.mit.edu	37	chr11	102100566	102100566	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacatagaaggagaggagctGatgccaagtctgcaggaagc	14	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:102100566G>C	uc001pgt.2	+	9	1780	c.1410G>C	c.(1408-1410)CTG>CTC	p.L470L	YAP1_uc001pgs.2_Silent_p.L420L|YAP1_uc001pgu.2_Silent_p.L454L|YAP1_uc001pgv.2_Silent_p.L416L|YAP1_uc010ruo.1_Silent_p.L292L|YAP1_uc001pgw.2_Silent_p.L294L|YAP1_uc010rup.1_Silent_p.L235L	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	470	Transactivation domain.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		GAGAGGAGCTGATGCCAAGTC	0.463													0	0	0	1	0	14	104										C	102100566	G	C	102100566	2	2	68	1	0	0	0	0	0	0	0	1	17463	1277	45	1		1	YAP1	11	102100566	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2273012	102100566	32905950	587	21107										
CUL5	8065	broad.mit.edu	37	chr11	107959270	107959270	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttagggtgggattaaaaactCagcctgaatcaaaatgccct	9	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:107959270C>G	uc001pjv.2	+	12	1862	c.1195C>G	c.(1195-1197)CAG>GAG	p.Q399E	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	399					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		ATTAAAAACTCAGCCTGAATC	0.338													0	0	0	1	0	13	76										G	107959270	C	G	107959270	3	3	68	1	0	0	0	0	1	0	0	0	4059	827	29	1	1241	1	CUL5	11	107959270	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5858704	107959270	27047246	588	21108										
EXPH5	23086	broad.mit.edu	37	chr11	108381565	108381565	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctgacttctgcatttcatCttcagccttcctgctctctg	6	14	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:108381565C>G	uc001pkk.2	-	6	4780	c.4669G>C	c.(4669-4671)GAT>CAT	p.D1557H	EXPH5_uc010rvy.1_Missense_Mutation_p.D1369H|EXPH5_uc010rvz.1_Missense_Mutation_p.D1401H|EXPH5_uc010rwa.1_Missense_Mutation_p.D1481H	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1557					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGCATTTCATCTTCAGCCTTC	0.418													0	0	0	1	0	21	117										G	108381565	C	G	108381565	3	3	68	1	0	0	0	0	1	0	0	0	5322	913	32	1	1304	1	EXPH5	11	108381565	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	422295	108381565	26624951	589	21109										
RDX	5962	broad.mit.edu	37	chr11	110134918	110134918	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagaatttagctctaaacttGaactgtaaaggattctcttt	6	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:110134918G>C	uc001pku.2	-	5	544	c.234C>G	c.(232-234)TTC>TTG	p.F78L	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Missense_Mutation_p.F78L|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Missense_Mutation_p.F46L|RDX_uc010rwe.1_Intron	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	78	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		CTCTAAACTTGAACTGTAAAG	0.303													0	0	0	1	0	21	30										C	110134918	G	C	110134918	3	2	68	1	0	0	0	0	1	0	0	0	13198	1281	45	1	1557	1	RDX	11	110134918	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1753353	110134918	24871598	590	21110										
ARHGAP20	57569	broad.mit.edu	37	chr11	110450129	110450129	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taaatacctgtcctcaatgtCgcagaccactgtaggccctg	8	13	1	1	rs148304862	by1000genomes	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:110450129C>T	uc001pkz.1	-	16	3826	c.3541G>A	c.(3541-3543)GAC>AAC	p.D1181N	ARHGAP20_uc001pky.1_Missense_Mutation_p.D1158N|ARHGAP20_uc009yyb.1_Missense_Mutation_p.D1145N|ARHGAP20_uc001pla.1_Missense_Mutation_p.D1145N|ARHGAP20_uc001plb.2_Missense_Mutation_p.D724N	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1181					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCTCAATGTCGCAGACCACT	0.448													0	0	0	1	0	23	125										T	110450129	C	T	110450129	3	4	68	1	0	0	0	0	1	0	0	0	870	884	31	1	38	1	ARHGAP20	11	110450129	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	315211	110450129	24556387	591	21111										
SDHD	6392	broad.mit.edu	37	chr11	111965691	111965691	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttgccatgctgtggaagctCtgacctttttgacttcatac	9	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:111965691C>G	uc001pmz.2	+	4	538	c.477C>G	c.(475-477)CTC>CTG	p.L159L		NM_003002	NP_002993	O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D	159	Mitochondrial intermembrane (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	TGTGGAAGCTCTGACCTTTTT	0.423			Mis|N|F|S			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				0	0	0	1	0	24	66										G	111965691	C	G	111965691	2	3	68	1	0	0	0	0	0	0	0	1	13967	900	32	1		1	SDHD	11	111965691	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1515562	111965691	23040825	592	21112										
PAFAH1B2	5049	broad.mit.edu	37	chr11	117023231	117023231	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agatattcaaggagatgaccGatggatgtctcaggtaaaag	12	5	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:117023231G>C	uc001pqe.1	+	2	170	c.68G>C	c.(67-69)CGA>CCA	p.R23P	PAFAH1B2_uc009yzk.1_Missense_Mutation_p.R23P|PAFAH1B2_uc009yzl.1_Missense_Mutation_p.R23P|PAFAH1B2_uc009yzm.2_RNA|PAFAH1B2_uc009yzn.2_RNA|PAFAH1B2_uc009yzj.1_Intron	NM_002572	NP_002563	P68402	PA1B2_HUMAN	platelet-activating factor acetylhydrolase,	23					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity			kidney(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;1.68e-05)|Epithelial(105;0.000162)|all cancers(92;0.00111)		GGAGATGACCGATGGATGTCT	0.353			T	IGH@	MLCLS								0	0	0	1	0	6	55										C	117023231	G	C	117023231	3	2	68	1	0	0	0	0	1	0	0	0	11385	1058	37	1	70	1	PAFAH1B2	11	117023231	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5057540	117023231	17983285	593	21113										
IL10RA	3587	broad.mit.edu	37	chr11	117859132	117859132	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccctccgtctgtgtggtttGaagcagaatttttccaccac	9	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:117859132G>C	uc001prv.2	+	2	180	c.103G>C	c.(103-105)GAA>CAA	p.E35Q	IL10RA_uc010rxl.1_Missense_Mutation_p.E15Q|IL10RA_uc010rxm.1_Missense_Mutation_p.E15Q|IL10RA_uc010rxn.1_5'UTR|IL10RA_uc001prw.2_5'UTR	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	35	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TGTGTGGTTTGAAGCAGAATT	0.468													0	0	0	1	0	30	110										C	117859132	G	C	117859132	3	2	68	1	0	0	0	0	1	0	0	0	7620	1291	45	1	109	1	IL10RA	11	117859132	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	835901	117859132	17147384	594	21114										
CD3G	917	broad.mit.edu	37	chr11	118221328	118221328	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggctttctctttgctgaaatCgtcagcattttcgtccttgc	8	11	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118221328C>T	uc001psu.2	+	4	449	c.369C>T	c.(367-369)ATC>ATT	p.I123I	CD3G_uc009zaa.1_Silent_p.I63I	NM_000073	NP_000064	P09693	CD3G_HUMAN	CD3G antigen, gamma polypeptide precursor	123	Helical; (Potential).				establishment or maintenance of cell polarity|protein complex assembly|protein transport|regulation of apoptosis|T cell activation|T cell costimulation|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	protein heterodimerization activity|receptor signaling complex scaffold activity|T cell receptor binding|transmembrane receptor activity				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		TTGCTGAAATCGTCAGCATTT	0.463													0	0	0	1	0	27	103										T	118221328	C	T	118221328	2	4	68	1	0	0	0	0	0	0	0	1	3013	874	31	1		1	CD3G	11	118221328	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	362196	118221328	16785188	595	21115										
MLL	4297	broad.mit.edu	37	chr11	118369132	118369132	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccaccgtgggttgctgtctCacatcctgcaccagcaacta	9	15	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118369132C>T	uc001pta.2	+	22	5864	c.5841C>T	c.(5839-5841)CTC>CTT	p.L1947L	MLL_uc001ptb.2_Silent_p.L1950L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1947					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GTTGCTGTCTCACATCCTGCA	0.423			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	1	0	105	191										T	118369132	C	T	118369132	2	4	68	1	0	0	0	0	0	0	0	1	9620	813	29	1		1	MLL	11	118369132	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	147804	118369132	16637384	596	21116										
MLL	4297	broad.mit.edu	37	chr11	118375134	118375134	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagacaataacaacagtgatGactgtgggaatatcctgcct	9	9	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118375134G>A	uc001pta.2	+	27	8541	c.8518G>A	c.(8518-8520)GAC>AAC	p.D2840N	MLL_uc001ptb.2_Missense_Mutation_p.D2843N	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2840					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAACAGTGATGACTGTGGGAA	0.443			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	1	0	56	129										A	118375134	G	A	118375134	3	1	68	1	0	0	0	0	1	0	0	0	9620	1290	45	1	8624	1	MLL	11	118375134	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6002	118375134	16631382	597	21117										
MLL	4297	broad.mit.edu	37	chr11	118390358	118390358	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacggtttgaggatgctgggGattctccatgatgcagttgt	14	6	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118390358G>A	uc001pta.2	+	32	11186	c.11163G>A	c.(11161-11163)GGG>GGA	p.G3721G	MLL_uc001ptb.2_Silent_p.G3724G	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3721	FYR C-terminal.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GGATGCTGGGGATTCTCCATG	0.493			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	1	0	22	151										A	118390358	G	A	118390358	2	1	68	1	0	0	0	0	0	0	0	1	9620	1161	41	1		1	MLL	11	118390358	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	15224	118390358	16616158	598	21118										
MLL	4297	broad.mit.edu	37	chr11	118390449	118390449	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccgtttccacaagccagagGaggccaatgaaccccccttg	9	15	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118390449G>T	uc001pta.2	+	32	11277	c.11254G>T	c.(11254-11256)GAG>TAG	p.E3752*	MLL_uc001ptb.2_Nonsense_Mutation_p.E3755*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3752					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAAGCCAGAGGAGGCCAATGA	0.522			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								1	0	3.45872e-05	1	3.61359e-05	16	107										T	118390449	G	T	118390449	4	4	68	1	0	0	0	0	0	1	0	0	9620	1175	41	3	11380	3	MLL	11	118390449	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	91	118390449	16616067	599	21119										
UPK2	7379	broad.mit.edu	37	chr11	118827612	118827612	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gacttcaacatctcaagcctCtctggtctgctgtccccggc	8	16	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118827612C>G	uc001puh.2	+	2	131	c.96C>G	c.(94-96)CTC>CTG	p.L32L		NM_006760	NP_006751	O00526	UPK2_HUMAN	uroplakin 2 precursor	32					cellular membrane organization|epithelial cell differentiation|multicellular organismal development	integral to endoplasmic reticulum membrane|integral to plasma membrane				skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.122)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		TCTCAAGCCTCTCTGGTCTGC	0.627											OREG0021391	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	12	68										G	118827612	C	G	118827612	2	3	68	1	0	0	0	0	0	0	0	1	17006	900	32	1		1	UPK2	11	118827612	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	437163	118827612	16178904	600	21120										
UPK2	7379	broad.mit.edu	37	chr11	118827675	118827675	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccttgcccccctgtcacctCacaggaggcaatgccacact	8	18	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118827675C>T	uc001puh.2	+	2	194	c.159C>T	c.(157-159)CTC>CTT	p.L53L		NM_006760	NP_006751	O00526	UPK2_HUMAN	uroplakin 2 precursor	53					cellular membrane organization|epithelial cell differentiation|multicellular organismal development	integral to endoplasmic reticulum membrane|integral to plasma membrane				skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.122)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		CCTGTCACCTCACAGGAGGCA	0.592											OREG0021391	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	10	79										T	118827675	C	T	118827675	2	4	68	1	0	0	0	0	0	0	0	1	17006	813	29	1		1	UPK2	11	118827675	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	63	118827675	16178841	601	21121										
TRAPPC4	51399	broad.mit.edu	37	chr11	118889918	118889918	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtacacggccgacgggaaaGaggtgctggagtatctgggt	18	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:118889918G>C	uc010ryo.1	+	2	506	c.241G>C	c.(241-243)GAG>CAG	p.E81Q	RPS25_uc001pun.2_5'Flank|TRAPPC4_uc010ryn.1_Missense_Mutation_p.E81Q|TRAPPC4_uc010ryp.1_Missense_Mutation_p.E81Q|TRAPPC4_uc001pup.2_RNA|TRAPPC4_uc010ryq.1_Missense_Mutation_p.E81Q	NM_016146	NP_057230	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	81					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		CGACGGGAAAGAGGTGCTGGA	0.562													0	0	0	1	0	13	62										C	118889918	G	C	118889918	3	2	68	1	0	0	0	0	1	0	0	0	16458	943	33	1	247	1	TRAPPC4	11	118889918	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	62243	118889918	16116598	602	21122										
CBL	867	broad.mit.edu	37	chr11	119149302	119149302	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtagatccgtttgatcctaGagggagtggcagcctgttga	15	7	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:119149302G>T	uc001pwe.2	+	9	1448	c.1310G>T	c.(1309-1311)AGA>ATA	p.R437I		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	437	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TTTGATCCTAGAGGGAGTGGC	0.483									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				1	0	1.36615e-20	1	1.57057e-20	36	78										T	119149302	G	T	119149302	3	4	68	1	0	0	0	0	1	0	0	0	2700	942	33	3	1344	3	CBL	11	119149302	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	259384	119149302	15857214	603	21123										
CBL	867	broad.mit.edu	37	chr11	119149399	119149399	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgatgatactctcttcatGatgaaggaattggctggtgc	12	7	2	4	rs138277394		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:119149399G>A	uc001pwe.2	+	9	1545	c.1407G>A	c.(1405-1407)ATG>ATA	p.M469I		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	469	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTCTCTTCATGATGAAGGAAT	0.463									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				0	0	0	1	0	21	55										A	119149399	G	A	119149399	3	1	68	1	0	0	0	0	1	0	0	0	2700	1290	45	1	1441	1	CBL	11	119149399	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	97	119149399	15857117	604	21124										
SORL1	6653	broad.mit.edu	37	chr11	121384943	121384943	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgcaccaatttatacatctCagaggcagaggggctgaagt	11	10	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:121384943C>G	uc001pxx.2	+	8	1204	c.1124C>G	c.(1123-1125)TCA>TGA	p.S375*		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	375	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TTATACATCTCAGAGGCAGAG	0.512													0	0	0	1	0	15	70										G	121384943	C	G	121384943	4	3	68	1	0	0	0	0	0	1	0	0	14934	838	29	1	1154	1	SORL1	11	121384943	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2235544	121384943	13621573	605	21125										
SORL1	6653	broad.mit.edu	37	chr11	121424706	121424706	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctaccgctatgacctggcctCgggagccaccgagcagttgc	12	15	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:121424706C>T	uc001pxx.2	+	17	2407	c.2327C>T	c.(2326-2328)TCG>TTG	p.S776L		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	776	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GACCTGGCCTCGGGAGCCACC	0.567													0	0	0	1	0	47	134										T	121424706	C	T	121424706	3	4	68	1	0	0	0	0	1	0	0	0	14934	893	31	1	2393	1	SORL1	11	121424706	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	39763	121424706	13581810	606	21126										
BSX	390259	broad.mit.edu	37	chr11	122848503	122848503	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaaccgcgggggctgccctCggggctttctggcccgtctg	16	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:122848503C>A	uc010rzs.1	-	3	556	c.556G>T	c.(556-558)GAG>TAG	p.E186*		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	186											0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GGGCTGCCCTCGGGGCTTTCT	0.647													1	0	0.00307968	1	0.00313441	8	32										A	122848503	C	A	122848503	4	1	68	1	0	0	0	0	0	1	0	0	1535	893	31	3	148	3	BSX	11	122848503	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1423797	122848503	12158013	607	21127										
SLC37A2	219855	broad.mit.edu	37	chr11	124933296	124933296	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggctccgggagtctggttCttccgggccttctccaggga	14	13	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:124933296C>T	uc001qbn.2	+	1	284	c.33C>T	c.(31-33)TTC>TTT	p.F11F	SLC37A2_uc010sau.1_Silent_p.F11F	NM_001145290	NP_001138762	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glycerol-3-phosphate	11					carbohydrate transport|transmembrane transport	integral to membrane				ovary(2)	2	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		GAGTCTGGTTCTTCCGGGCCT	0.711													0	0	0	1	0	5	12										T	124933296	C	T	124933296	2	4	68	1	0	0	0	0	0	0	0	1	14598	912	32	1		1	SLC37A2	11	124933296	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2084793	124933296	10073220	608	21128										
NFRKB	4798	broad.mit.edu	37	chr11	129752028	129752028	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagcaagatctctaatagaaGagagaagaagctggaagata	11	5	1	6			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr11:129752028G>A	uc001qfi.2	-	11	1345	c.1144C>T	c.(1144-1146)CTT>TTT	p.L382F	NFRKB_uc001qfg.2_Missense_Mutation_p.L407F|NFRKB_uc001qfh.2_Missense_Mutation_p.L405F|NFRKB_uc010sbw.1_Missense_Mutation_p.L394F	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	382					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TCTAATAGAAGAGAGAAGAAG	0.403											OREG0021512	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	16	16										A	129752028	G	A	129752028	3	1	68	1	0	0	0	0	1	0	0	0	10384	942	33	1	2823	1	NFRKB	11	129752028	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4818732	129752028	5254488	609	21129										
NINJ2	4815	broad.mit.edu	37	chr12	674518	674518	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagatggtggctgcgttgttGagctggttgagtcgccactg	16	7	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:674518G>A	uc001qil.2	-	3	541	c.450C>T	c.(448-450)CTC>CTT	p.L150L		NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	104	Cytoplasmic (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			CTGCGTTGTTGAGCTGGTTGA	0.557													0	0	0	1	0	18	93										A	674518	G	A	674518	2	1	68	1	0	0	0	0	0	0	0	1	10419	1277	45	1		1	NINJ2	12	674518	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		674518	133177377	610	21130										
CACNA1C	775	broad.mit.edu	37	chr12	2797857	2797857	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggcagcagcgccgcccggaGagtccggcccgtctccctca	14	18	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:2797857G>T	uc009zdu.1	+	49	6591	c.6278G>T	c.(6277-6279)AGA>ATA	p.R2093I	CACNA1C_uc009zdv.1_Missense_Mutation_p.R2007I|CACNA1C_uc001qkb.2_Missense_Mutation_p.R2010I|CACNA1C_uc001qkc.2_Missense_Mutation_p.R2029I|CACNA1C_uc001qke.2_Missense_Mutation_p.R1999I|CACNA1C_uc001qkf.2_Missense_Mutation_p.R2018I|CACNA1C_uc001qjz.2_Missense_Mutation_p.R2010I|CACNA1C_uc001qkd.2_Missense_Mutation_p.R2029I|CACNA1C_uc001qkg.2_Missense_Mutation_p.R2016I|CACNA1C_uc009zdw.1_Missense_Mutation_p.R2051I|CACNA1C_uc001qkh.2_Missense_Mutation_p.R2018I|CACNA1C_uc001qkl.2_Missense_Mutation_p.R2058I|CACNA1C_uc001qkn.2_Missense_Mutation_p.R2010I|CACNA1C_uc001qko.2_Missense_Mutation_p.R2030I|CACNA1C_uc001qkp.2_Missense_Mutation_p.R2010I|CACNA1C_uc001qkr.2_Missense_Mutation_p.R2027I|CACNA1C_uc001qku.2_Missense_Mutation_p.R2045I|CACNA1C_uc001qkq.2_Missense_Mutation_p.R2038I|CACNA1C_uc001qks.2_Missense_Mutation_p.R2010I|CACNA1C_uc001qkt.2_Missense_Mutation_p.R2029I|CACNA1C_uc001qki.1_Missense_Mutation_p.R1817I|CACNA1C_uc001qkj.1_Missense_Mutation_p.R1781I|CACNA1C_uc001qkk.1_Missense_Mutation_p.R1746I|CACNA1C_uc001qkm.1_Missense_Mutation_p.R1806I|CACNA1C_uc010sea.1_Missense_Mutation_p.R701I|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.R328I	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2093	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCCGCCCGGAGAGTCCGGCCC	0.692													1	0	0.00116845	1	0.00119403	6	33										T	2797857	G	T	2797857	3	4	68	1	0	0	0	0	1	0	0	0	2540	942	33	3	6920	3	CACNA1C	12	2797857	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2123339	2797857	131054038	611	21131										
C12orf4	57102	broad.mit.edu	37	chr12	4643350	4643350	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taagctttggcccatgtactCgccagctgatgtaaatctac	8	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:4643350C>T	uc001qms.2	-	3	385	c.297G>A	c.(295-297)GCG>GCA	p.A99A	C12orf4_uc001qmt.2_Silent_p.A99A	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	99											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CCCATGTACTCGCCAGCTGAT	0.393													0	0	0	1	0	32	55										T	4643350	C	T	4643350	2	4	68	1	0	0	0	0	0	0	0	1	1685	871	31	1		1	C12orf4	12	4643350	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1845493	4643350	129208545	612	21132										
NOP2	4839	broad.mit.edu	37	chr12	6675398	6675398	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcagagtcttcctcctcctCttcctcatcactgccaggtg	6	16	5	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:6675398C>A	uc001qpk.1	-	4	387	c.343G>T	c.(343-345)GAG>TAG	p.E115*	NOP2_uc009zeq.1_5'Flank|NOP2_uc001qph.1_Nonsense_Mutation_p.E111*|NOP2_uc001qpi.1_Nonsense_Mutation_p.E111*|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Nonsense_Mutation_p.E115*|NOP2_uc001qpm.1_Nonsense_Mutation_p.E115*			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	115					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						TCCTCCTCCTCTTCCTCATCA	0.562													1	0	1.33987e-11	1	1.49799e-11	11	34										A	6675398	C	A	6675398	4	1	68	1	0	0	0	0	0	1	0	0	10538	922	32	3	2143	3	NOP2	12	6675398	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2032048	6675398	127176497	613	21133										
C12orf53	196500	broad.mit.edu	37	chr12	6804697	6804697	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgggggtaggtgagtccccGaaggcccccagcacagtgac	16	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:6804697G>T	uc001qqf.1	-	5	802	c.726C>A	c.(724-726)TTC>TTA	p.F242L	C12orf53_uc001qqg.1_Missense_Mutation_p.F242L	NM_153685	NP_710152	Q8IYJ0	CL053_HUMAN	hypothetical protein LOC196500 precursor	242	Cytoplasmic (Potential).					integral to membrane					0						GTGAGTCCCCGAAGGCCCCCA	0.692													1	0	0.000673444	1	0.000690993	11	45										T	6804697	G	T	6804697	3	4	68	1	0	0	0	0	1	0	0	0	1698	1049	37	3	130	3	C12orf53	12	6804697	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	129299	6804697	127047198	614	21134										
GNB3	2784	broad.mit.edu	37	chr12	6954828	6954828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgacctgcgggcagaccagGagctgatctgcttctcccac	11	14	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:6954828G>A	uc001qrd.2	+	10	1183	c.778G>A	c.(778-780)GAG>AAG	p.E260K	GNB3_uc001qrc.2_Missense_Mutation_p.E216K|GNB3_uc009zfe.2_Missense_Mutation_p.E259K|CDCA3_uc001qre.2_3'UTR|uc001qrf.1_RNA	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	260					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GGCAGACCAGGAGCTGATCTG	0.607													0	0	0	1	0	47	135										A	6954828	G	A	6954828	3	1	68	1	0	0	0	0	1	0	0	0	6519	1175	41	1	808	1	GNB3	12	6954828	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	150131	6954828	126897067	615	21135										
ZNF705A	440077	broad.mit.edu	37	chr12	8329747	8329747	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaatctcttcgtaatcttttCtcccctaaaccacataaaca	1	13	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:8329747C>G	uc001qud.1	+	5	543	c.471C>G	c.(469-471)TTC>TTG	p.F157L		NM_001004328	NP_001004328	Q6ZN79	Z705A_HUMAN	zinc finger protein 705A	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				Kidney(36;0.0877)		GTAATCTTTTCTCCCCTAAAC	0.373													0	0	0	1	0	43	227										G	8329747	C	G	8329747	3	3	68	1	0	0	0	0	1	0	0	0	18105	912	32	1	489	1	ZNF705A	12	8329747	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1374919	8329747	125522148	616	21136										
PZP	5858	broad.mit.edu	37	chr12	9305777	9305777	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gacatattctccagggagctCtggcaatgagatctgctgca	11	10	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:9305777C>G	uc001qvl.2	-	30	3966	c.3937G>C	c.(3937-3939)GAG>CAG	p.E1313Q	PZP_uc009zgl.2_Missense_Mutation_p.E1099Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						CCAGGGAGCTCTGGCAATGAG	0.433													0	0	0	1	0	60	137										G	9305777	C	G	9305777	3	3	68	1	0	0	0	0	1	0	0	0	12869	922	32	1	539	1	PZP	12	9305777	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	976030	9305777	124546118	617	21137										
PZP	5858	broad.mit.edu	37	chr12	9321515	9321515	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagacacggaagggatgactGaacacgactttggttttcgg	13	8	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:9321515G>C	uc001qvl.2	-	17	2086	c.2057C>G	c.(2056-2058)TCA>TGA	p.S686*	PZP_uc009zgl.2_Nonsense_Mutation_p.S555*|PZP_uc010sgo.1_5'Flank|PZP_uc009zgm.1_Nonsense_Mutation_p.S18*	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AGGGATGACTGAACACGACTT	0.368													0	0	0	1	0	12	84										C	9321515	G	C	9321515	4	2	68	1	0	0	0	0	0	1	0	0	12869	1294	45	1	2471	1	PZP	12	9321515	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	15738	9321515	124530380	618	21138										
DUSP16	80824	broad.mit.edu	37	chr12	12673996	12673996	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagcagagccaccaacctctCagtaacaatttgagttccaa	6	13	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:12673996C>T	uc001rao.1	-	2	669	c.37G>A	c.(37-39)GAG>AAG	p.E13K	DUSP16_uc001ran.1_5'UTR	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	13					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		ACCAACCTCTCAGTAACAATT	0.438													0	0	0	1	0	7	31										T	12673996	C	T	12673996	3	4	68	1	0	0	0	0	1	0	0	0	4816	835	29	1	1984	1	DUSP16	12	12673996	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3352481	12673996	121177899	619	21139										
GSG1	83445	broad.mit.edu	37	chr12	13238096	13238096	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcttactatgcttgcacttGaactccagcaccatcctggt	6	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:13238096G>C	uc001rbn.2	-	7	1001	c.828C>G	c.(826-828)TTC>TTG	p.F276L	GSG1_uc001rbj.2_Missense_Mutation_p.F240L|GSG1_uc001rbk.2_Missense_Mutation_p.Q282E|GSG1_uc001rbl.2_Missense_Mutation_p.F212L|GSG1_uc001rbm.2_Missense_Mutation_p.F189L|GSG1_uc001rbo.2_Missense_Mutation_p.Q318E|GSG1_uc001rbp.2_Missense_Mutation_p.F253L|GSG1_uc001rbq.1_Missense_Mutation_p.Q318E	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	263						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GCTTGCACTTGAACTCCAGCA	0.557													0	0	0	1	0	6	58										C	13238096	G	C	13238096	3	2	68	1	0	0	0	0	1	0	0	0	6820	1299	45	1	264	1	GSG1	12	13238096	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	564100	13238096	120613799	620	21140										
KIAA0528	9847	broad.mit.edu	37	chr12	22697070	22697070	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccggccacgattttcaccttCagcttccctggcatggtctc	8	16	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:22697070C>T	uc001rfq.2	-	2	243	c.15G>A	c.(13-15)CTG>CTA	p.L5L	KIAA0528_uc010sis.1_Silent_p.L5L|KIAA0528_uc010sit.1_Silent_p.L5L|KIAA0528_uc010siu.1_Silent_p.L5L|KIAA0528_uc001rfr.2_Silent_p.L5L|KIAA0528_uc009ziy.1_Silent_p.L5L	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	5	C2.						protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TTTTCACCTTCAGCTTCCCTG	0.627													0	0	0	1	0	21	51										T	22697070	C	T	22697070	2	4	68	1	0	0	0	0	0	0	0	1	8182	813	29	1		1	KIAA0528	12	22697070	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	9458974	22697070	111154825	621	21141										
ITPR2	3709	broad.mit.edu	37	chr12	26714780	26714780	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccagagcgagctgatagtCtccaacccattgctgctctc	9	15	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:26714780C>A	uc001rhg.2	-	35	5153	c.4736G>T	c.(4735-4737)AGA>ATA	p.R1579I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1579	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AGCTGATAGTCTCCAACCCAT	0.448													1	0	3.09899e-07	1	3.31189e-07	9	52										A	26714780	C	A	26714780	3	1	68	1	0	0	0	0	1	0	0	0	7921	913	32	3	3461	3	ITPR2	12	26714780	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4017710	26714780	107137115	622	21142										
OVCH1	341350	broad.mit.edu	37	chr12	29604325	29604325	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttcataaataattagaactGagtcttgacacacaggagac	7	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:29604325G>C	uc001rix.1	-	22	2708	c.2708C>G	c.(2707-2709)TCA>TGA	p.S903*		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	903	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AATTAGAACTGAGTCTTGACA	0.438													0	0	0	1	0	6	36										C	29604325	G	C	29604325	4	2	68	1	0	0	0	0	0	1	0	0	11323	1294	45	1	724	1	OVCH1	12	29604325	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2889545	29604325	104247570	623	21143										
KIF21A	55605	broad.mit.edu	37	chr12	39726897	39726897	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catgggtcttacttgccgacGaagagccgtaacctgaaatt	10	10	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:39726897G>A	uc001rly.2	-	19	2646	c.2500C>T	c.(2500-2502)CGT>TGT	p.R834C	KIF21A_uc001rlv.2_5'Flank|KIF21A_uc001rlw.2_Missense_Mutation_p.R151C|KIF21A_uc001rlx.2_Missense_Mutation_p.R821C|KIF21A_uc001rlz.2_Missense_Mutation_p.R798C|KIF21A_uc010skl.1_Missense_Mutation_p.R821C	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	834					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				ACTTGCCGACGAAGAGCCGTA	0.448													0	0	0	1	0	49	93										A	39726897	G	A	39726897	3	1	68	1	0	0	0	0	1	0	0	0	8288	1058	37	1	2604	1	KIF21A	12	39726897	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10122572	39726897	94124998	624	21144										
KIF21A	55605	broad.mit.edu	37	chr12	39751995	39751995	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttactgttttgtactccatGagctccatctgaagtcgtgt	8	10	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:39751995G>C	uc001rly.2	-	8	1346	c.1200C>G	c.(1198-1200)CTC>CTG	p.L400L	KIF21A_uc001rlx.2_Silent_p.L400L|KIF21A_uc001rlz.2_Silent_p.L400L|KIF21A_uc010skl.1_Silent_p.L400L|KIF21A_uc001rma.1_Silent_p.L408L	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	400	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TGTACTCCATGAGCTCCATCT	0.398													0	0	0	1	0	35	206										C	39751995	G	C	39751995	2	2	68	1	0	0	0	0	0	0	0	1	8288	1277	45	1		1	KIF21A	12	39751995	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	25098	39751995	94099900	625	21145										
ABCD2	225	broad.mit.edu	37	chr12	40001459	40001459	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccagaggccagtaaatttCgagcagtggtaaaggcttct	11	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:40001459C>T	uc001rmb.2	-	3	1604	c.1178G>A	c.(1177-1179)CGA>CAA	p.R393Q		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	393	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						CAGTAAATTTCGAGCAGTGGT	0.323													0	0	0	1	0	26	71										T	40001459	C	T	40001459	3	4	68	1	0	0	0	0	1	0	0	0	61	884	31	1	1076	1	ABCD2	12	40001459	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	249464	40001459	93850436	626	21146										
CNTN1	1272	broad.mit.edu	37	chr12	41312446	41312446	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcatatttcttgtagtttctGaggaagacaaaggatttgga	10	4	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:41312446G>A	uc001rmm.1	+	4	213	c.100G>A	c.(100-102)GAG>AAG	p.E34K	CNTN1_uc009zjy.1_Missense_Mutation_p.E34K|CNTN1_uc001rmn.1_Missense_Mutation_p.E23K|CNTN1_uc001rmo.2_Missense_Mutation_p.E34K	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	34					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGTAGTTTCTGAGGAAGACAA	0.323													0	0	0	1	0	7	40										A	41312446	G	A	41312446	3	1	68	1	0	0	0	0	1	0	0	0	3640	1291	45	1	110	1	CNTN1	12	41312446	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1310987	41312446	92539449	627	21147										
PLEKHA9	51054	broad.mit.edu	37	chr12	45567593	45567593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gataacttctttgccttcctCccagaggcattctggagagc	9	12	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:45567593C>T	uc001rom.1	-	3	1093	c.556G>A	c.(556-558)GAG>AAG	p.E186K	PLEKHA9_uc009zke.2_Missense_Mutation_p.E186K	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		TTGCCTTCCTCCCAGAGGCAT	0.403													0	0	0	1	0	79	114										T	45567593	C	T	45567593	3	4	68	1	0	0	0	0	1	0	0	0	12063	864	30	1	623	1	PLEKHA9	12	45567593	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4255147	45567593	88284302	628	21148										
TMEM106C	79022	broad.mit.edu	37	chr12	48358114	48358114	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctggctgaacgagagcaggAagaagccattgctcagttcc	13	10	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:48358114A>T	uc001rqp.2	+	2	210	c.95A>T	c.(94-96)GAA>GTA	p.E32V	TMEM106C_uc001rqo.2_Missense_Mutation_p.E32V|TMEM106C_uc001rqr.2_Missense_Mutation_p.E32V|TMEM106C_uc001rqq.2_Missense_Mutation_p.E32V	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	32						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		CGAGAGCAGGAAGAAGCCATT	0.562													0	0	0	1	0	8	38										T	48358114	A	T	48358114	3	4	68	1	0	0	0	0	1	0	0	0	16019	246	9	5	97	5	TMEM106C	12	48358114	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2790521	48358114	85493781	629	21149										
SENP1	29843	broad.mit.edu	37	chr12	48482603	48482603	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttgaggtctttcgggtttCgaggtaaagacttcggctgt	13	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:48482603C>T	uc001rqx.2	-	5	807	c.361G>A	c.(361-363)GAA>AAA	p.E121K	SENP1_uc001rqw.2_Missense_Mutation_p.E121K|SENP1_uc001rqy.2_5'UTR|SENP1_uc001rqz.2_5'UTR|SENP1_uc009zkx.2_Missense_Mutation_p.E121K	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	121	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TTTCGGGTTTCGAGGTAAAGA	0.403													0	0	0	1	0	5	9										T	48482603	C	T	48482603	3	4	68	1	0	0	0	0	1	0	0	0	14046	893	31	1	1626	1	SENP1	12	48482603	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	124489	48482603	85369292	630	21150										
OR10AD1	121275	broad.mit.edu	37	chr12	48597027	48597027	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtggaagtggagctctgctGaaagcccacgaggataaatt	13	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:48597027G>T	uc001rrl.1	-	1	49	c.49C>A	c.(49-51)CAG>AAG	p.Q17K		NM_001004134	NP_001004134	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAGCTCTGCTGAAAGCCCACG	0.507													1	0	0.248553	1	0.24875	6	52										T	48597027	G	T	48597027	3	4	68	1	0	0	0	0	1	0	0	0	10896	1299	45	3	908	3	OR10AD1	12	48597027	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	114424	48597027	85254868	631	21151										
MLL2	8085	broad.mit.edu	37	chr12	49420241	49420241	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgcagccgttctccccgctGaatgatgctagcgatttgct	11	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:49420241G>A	uc001rta.3	-	48	15508	c.15508C>T	c.(15508-15510)CAG>TAG	p.Q5170*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5170					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCTCCCCGCTGAATGATGCTA	0.572			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	1	0	5	43										A	49420241	G	A	49420241	4	1	68	1	0	0	0	0	0	1	0	0	9621	1299	45	1	1133	1	MLL2	12	49420241	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	823214	49420241	84431654	632	21152										
FMNL3	91010	broad.mit.edu	37	chr12	50047084	50047084	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acccgcatcatgttttcattCtctaggtccagaagcttctc	6	13	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:50047084C>G	uc001ruv.1	-	13	1482	c.1248G>C	c.(1246-1248)GAG>GAC	p.E416D	FMNL3_uc001ruw.1_Missense_Mutation_p.E365D|FMNL3_uc001rut.1_5'Flank|FMNL3_uc001ruu.1_Missense_Mutation_p.E266D	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	416	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						TGTTTTCATTCTCTAGGTCCA	0.532													0	0	0	1	0	25	128										G	50047084	C	G	50047084	3	3	68	1	0	0	0	0	1	0	0	0	5953	912	32	1	1891	1	FMNL3	12	50047084	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	626843	50047084	83804811	633	21153										
LIMA1	51474	broad.mit.edu	37	chr12	50570907	50570907	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttatctgttcttccacagaGagctctttgaccacttctcc	5	13	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:50570907G>C	uc001rwj.3	-	11	2394	c.2220C>G	c.(2218-2220)CTC>CTG	p.L740L	LIMA1_uc001rwg.3_Silent_p.L438L|LIMA1_uc001rwh.3_Silent_p.L579L|LIMA1_uc001rwi.3_Silent_p.L581L|LIMA1_uc001rwk.3_Silent_p.L741L|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	740					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CTTCCACAGAGAGCTCTTTGA	0.423													0	0	0	1	0	60	274										C	50570907	G	C	50570907	2	2	68	1	0	0	0	0	0	0	0	1	8796	929	33	1		1	LIMA1	12	50570907	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	523823	50570907	83280988	634	21154										
KRT6A	3853	broad.mit.edu	37	chr12	52882123	52882123	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttacccacctgcactcctcAccctccagcagcttgcggta	7	18	1	0	rs1132960		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:52882123A>G	uc001sam.2	-	7	1622	c.1413T>C	c.(1411-1413)GGT>GGC	p.G471G		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	471	Rod.|Coil 2.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCACTCCTCACCCTCCAGCA	0.577													0	0	0	1	0	18	101										G	52882123	A	G	52882123	2	3	68	1	0	0	0	0	0	0	0	1	8480	146	6	5		5	KRT6A	12	52882123	Silent	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2311216	52882123	80969772	635	21155										
KRT5	3852	broad.mit.edu	37	chr12	52913532	52913532	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agatcgtagctcaccttgtcGatgaaggaggcaaacttatt	10	8	1	2	rs61726460		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:52913532G>A	uc001san.2	-	1	712	c.549C>T	c.(547-549)ATC>ATT	p.I183I	KRT5_uc009zmh.2_Silent_p.I183I	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	183	Coil 1A.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		TCACCTTGTCGATGAAGGAGG	0.468													0	0	0	1	0	28	100										A	52913532	G	A	52913532	2	1	68	1	0	0	0	0	0	0	0	1	8479	1048	37	1		1	KRT5	12	52913532	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	31409	52913532	80938363	636	21156										
RARG	5916	broad.mit.edu	37	chr12	53608346	53608346	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atagctgtcaggtgacccttCttccttcacctctttcttct	5	14	6	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:53608346C>T	uc001sce.2	-	6	1005	c.520G>A	c.(520-522)GAA>AAA	p.E174K	RARG_uc001scd.2_Missense_Mutation_p.E163K|RARG_uc010sob.1_Missense_Mutation_p.E152K|RARG_uc001scf.2_Missense_Mutation_p.E174K|RARG_uc001scg.2_Missense_Mutation_p.E102K|RARG_uc010soc.1_Missense_Mutation_p.E53K|RARG_uc010sod.1_Missense_Mutation_p.E211K	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	174	Hinge.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGTGACCCTTCTTCCTTCACC	0.557													0	0	0	1	0	11	25										T	53608346	C	T	53608346	3	4	68	1	0	0	0	0	1	0	0	0	13054	922	32	1	864	1	RARG	12	53608346	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	694814	53608346	80243549	637	21157										
SP7	121340	broad.mit.edu	37	chr12	53722170	53722170	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagagcaggcaggtgaacttCttctcccgggtgtgagtgcg	15	10	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:53722170C>T	uc001sct.2	-	2	1163	c.1056G>A	c.(1054-1056)AAG>AAA	p.K352K	SP7_uc001scu.2_Silent_p.K334K|SP7_uc001scv.2_Silent_p.K352K	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGTGAACTTCTTCTCCCGGG	0.622											OREG0021867	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	13	49										T	53722170	C	T	53722170	2	4	68	1	0	0	0	0	0	0	0	1	14969	912	32	1		1	SP7	12	53722170	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	113824	53722170	80129725	638	21158										
SP1	6667	broad.mit.edu	37	chr12	53776785	53776785	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatcatcagggaccaactctCaaggccagacaccccagagg	10	14	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:53776785C>T	uc001scw.2	+	3	1151	c.1054C>T	c.(1054-1056)CAA>TAA	p.Q352*	SP1_uc010sog.1_Nonsense_Mutation_p.Q345*	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	352	Transactivation domain B (Gln-rich).|Ser/Thr-rich.				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GACCAACTCTCAAGGCCAGAC	0.502													0	0	0	1	0	8	49										T	53776785	C	T	53776785	4	4	68	1	0	0	0	0	0	1	0	0	14959	827	29	1	1064	1	SP1	12	53776785	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	54615	53776785	80075110	639	21159										
SP1	6667	broad.mit.edu	37	chr12	53777068	53777068	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcttcaggctgttccaaactCtggtcccatcatcatccgga	8	14	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:53777068C>G	uc001scw.2	+	3	1434	c.1337C>G	c.(1336-1338)TCT>TGT	p.S446C	SP1_uc010sog.1_Missense_Mutation_p.S439C	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	446	Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GTTCCAAACTCTGGTCCCATC	0.557													0	0	0	1	0	19	86										G	53777068	C	G	53777068	3	3	68	1	0	0	0	0	1	0	0	0	14959	913	32	1	1347	1	SP1	12	53777068	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	283	53777068	80074827	640	21160										
AMHR2	269	broad.mit.edu	37	chr12	53825228	53825228	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccttgttccaggaatcctCagcctgcctgtaccctttct	7	16	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:53825228C>T	uc001scx.1	+	11	1771	c.1693C>T	c.(1693-1695)CAG>TAG	p.Q565*	AMHR2_uc009zmy.1_3'UTR	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	565	Cytoplasmic (Potential).				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	CAGGAATCCTCAGCCTGCCTG	0.498									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				0	0	0	1	0	32	45										T	53825228	C	T	53825228	4	4	68	1	0	0	0	0	0	1	0	0	573	827	29	1	1735	1	AMHR2	12	53825228	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	48160	53825228	80026667	641	21161										
MAP3K12	7786	broad.mit.edu	37	chr12	53881144	53881144	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaagcccccaaaggaaggaGagggtgttcgggtctcatgg	15	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:53881144G>A	uc001sdm.1	-	2	130	c.32C>T	c.(31-33)TCT>TTT	p.S11F	MAP3K12_uc001sdn.1_Missense_Mutation_p.S11F	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	11					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						AAAGGAAGGAGAGGGTGTTCG	0.597													0	0	0	1	0	26	47										A	53881144	G	A	53881144	3	1	68	1	0	0	0	0	1	0	0	0	9246	942	33	1	2603	1	MAP3K12	12	53881144	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	55916	53881144	79970751	642	21162										
HOXC8	3224	broad.mit.edu	37	chr12	54403245	54403245	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcgcaccacgttcaagacttCttccaccacggcacctccgg	7	18	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:54403245C>G	uc001ser.2	+	1	356	c.177C>G	c.(175-177)TTC>TTG	p.F59L		NM_022658	NP_073149	P31273	HXC8_HUMAN	homeobox C8	59						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCAAGACTTCTTCCACCACG	0.652													0	0	0	1	0	30	171										G	54403245	C	G	54403245	3	3	68	1	0	0	0	0	1	0	0	0	7316	912	32	1	179	1	HOXC8	12	54403245	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	522101	54403245	79448650	643	21163										
NCKAP1L	3071	broad.mit.edu	37	chr12	54917701	54917701	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgaacatactatcttcccttCtgagtacctcagcagccacc	5	15	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:54917701C>G	uc001sgc.3	+	20	2196	c.2117C>G	c.(2116-2118)TCT>TGT	p.S706C	NCKAP1L_uc010sox.1_Missense_Mutation_p.S248C|NCKAP1L_uc010soy.1_Missense_Mutation_p.S656C	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	706					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ATCTTCCCTTCTGAGTACCTC	0.448													0	0	0	1	0	9	67										G	54917701	C	G	54917701	3	3	68	1	0	0	0	0	1	0	0	0	10222	913	32	1	2195	1	NCKAP1L	12	54917701	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	514456	54917701	78934194	644	21164										
DGKA	1606	broad.mit.edu	37	chr12	56347534	56347534	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccccccgctccaccaatttCtttggcttcttgagctaagg	7	16	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:56347534C>A	uc001sij.2	+	24	2454	c.2190C>A	c.(2188-2190)TTC>TTA	p.F730L	DGKA_uc001sik.2_Missense_Mutation_p.F730L|DGKA_uc001sil.2_Missense_Mutation_p.F730L|DGKA_uc001sim.2_Missense_Mutation_p.F730L|DGKA_uc001sin.2_Missense_Mutation_p.F730L|DGKA_uc009zof.2_Missense_Mutation_p.F376L|DGKA_uc001sio.2_Missense_Mutation_p.F472L	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	730					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	CCACCAATTTCTTTGGCTTCT	0.582													1	0	1.02788e-11	1	1.15021e-11	17	47										A	56347534	C	A	56347534	3	1	68	1	0	0	0	0	1	0	0	0	4465	912	32	3	2280	3	DGKA	12	56347534	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1429833	56347534	77504361	645	21165										
OBFC2B	79035	broad.mit.edu	37	chr12	56618691	56618691	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagcctgggctcaagaatctGaaccttatcttcattgtgct	8	10	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:56618691G>T	uc001ski.2	+	2	175	c.51G>T	c.(49-51)CTG>CTT	p.L17L	OBFC2B_uc001skk.2_Silent_p.L42L|OBFC2B_uc001skj.2_Silent_p.L33L|RNF41_uc001ske.1_5'Flank|RNF41_uc001skf.1_5'Flank|RNF41_uc001skg.1_5'Flank|RNF41_uc010sqg.1_5'Flank|RNF41_uc010sqh.1_5'Flank|RNF41_uc001skh.2_5'Flank	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	17					double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						TCAAGAATCTGAACCTTATCT	0.577								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function			OREG0021922	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.12818e-05	1	8.44313e-05	6	52										T	56618691	G	T	56618691	2	4	68	1	0	0	0	0	0	0	0	1	10809	1277	45	3		3	OBFC2B	12	56618691	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	271157	56618691	77233204	646	21166										
PAN2	9924	broad.mit.edu	37	chr12	56715866	56715866	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actatgtagcacttactgttCaggttgtatctggaattgag	10	6	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:56715866C>T	uc001skx.2	-	20	3169	c.2796G>A	c.(2794-2796)CTG>CTA	p.L932L	PAN2_uc001skw.2_Silent_p.L80L|PAN2_uc001skz.2_Silent_p.L931L|PAN2_uc001sky.2_Silent_p.L928L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	932					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ACTTACTGTTCAGGTTGTATC	0.408													0	0	0	1	0	53	83										T	56715866	C	T	56715866	2	4	68	1	0	0	0	0	0	0	0	1	11414	813	29	1		1	PAN2	12	56715866	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	97175	56715866	77136029	647	21167										
OSBPL8	114882	broad.mit.edu	37	chr12	76750481	76750481	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagttctattcctttctttCttcttgtacttggttttact	4	10	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:76750481C>A	uc001sye.1	-	23	2942	c.2462G>T	c.(2461-2463)AGA>ATA	p.R821I	OSBPL8_uc001syf.1_Missense_Mutation_p.R779I|OSBPL8_uc001syg.1_Missense_Mutation_p.R779I	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	821					lipid transport		lipid binding			ovary(1)	1						TCCTTTCTTTCTTCTTGTACT	0.289													1	0	1.3612e-06	1	1.44492e-06	14	34										A	76750481	C	A	76750481	3	1	68	1	0	0	0	0	1	0	0	0	11283	913	32	3	215	3	OSBPL8	12	76750481	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	20034615	76750481	57101414	648	21168										
ATP2B1	490	broad.mit.edu	37	chr12	89996871	89996871	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagaagatggcattgttaaaGattccttcgaatacatttct	7	7	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:89996871G>A	uc001tbh.2	-	17	3190	c.3009C>T	c.(3007-3009)ATC>ATT	p.I1003I	ATP2B1_uc001tbg.2_Silent_p.I1003I|ATP2B1_uc001tbf.2_Silent_p.I673I	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	1003	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						CATTGTTAAAGATTCCTTCGA	0.343													0	0	0	1	0	17	45										A	89996871	G	A	89996871	2	1	68	1	0	0	0	0	0	0	0	1	1139	932	33	1		1	ATP2B1	12	89996871	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	13246390	89996871	43855024	649	21169										
ANO4	121601	broad.mit.edu	37	chr12	101442134	101442134	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacaggtaacccacctttttGacaatggagccactgtcttc	7	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:101442134G>A	uc010svm.1	+	14	1839	c.1267G>A	c.(1267-1269)GAC>AAC	p.D423N	ANO4_uc001thw.2_Missense_Mutation_p.D388N|ANO4_uc001thx.2_Missense_Mutation_p.D423N|ANO4_uc001thy.2_5'UTR	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	423	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						CCACCTTTTTGACAATGGAGC	0.343										HNSCC(74;0.22)			0	0	0	1	0	15	65										A	101442134	G	A	101442134	3	1	68	1	0	0	0	0	1	0	0	0	699	1290	45	1	1208	1	ANO4	12	101442134	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11445263	101442134	32409761	650	21170										
UTP20	27340	broad.mit.edu	37	chr12	101702091	101702091	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctaagacatgatgtggtacaGactgctgtccctgatgggcc	12	10	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:101702091G>C	uc001tia.1	+	18	2280	c.2124G>C	c.(2122-2124)CAG>CAC	p.Q708H		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	708					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						ATGTGGTACAGACTGCTGTCC	0.383													0	0	0	1	0	14	52										C	101702091	G	C	101702091	3	2	68	1	0	0	0	0	1	0	0	0	17096	933	33	1	2194	1	UTP20	12	101702091	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	259957	101702091	32149804	651	21171										
CMKLR1	1240	broad.mit.edu	37	chr12	108685927	108685927	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgtggtaggggcaccagcaGaggaagaaggtaatgatgat	17	4	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:108685927G>A	uc009zuw.2	-	3	1004	c.813C>T	c.(811-813)CTC>CTT	p.L271L	CMKLR1_uc001tmw.2_Silent_p.L271L|CMKLR1_uc001tmv.2_Silent_p.L269L|CMKLR1_uc009zuv.2_Silent_p.L271L	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	271	Helical; Name=6; (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GGCACCAGCAGAGGAAGAAGG	0.562													0	0	0	1	0	8	39										A	108685927	G	A	108685927	2	1	68	1	0	0	0	0	0	0	0	1	3579	929	33	1		1	CMKLR1	12	108685927	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6983836	108685927	25165968	652	21172										
ACACB	32	broad.mit.edu	37	chr12	109577219	109577219	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagattttctgaatggtcttGcttctttgtctatcttgtct	7	8	6	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:109577219G>A	uc001tob.2	+	2	128	c.9G>A	c.(7-9)TTG>TTA	p.L3L	ACACB_uc001toc.2_Silent_p.L3L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	3					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GAATGGTCTTGCTTCTTTGTC	0.388													0	0	0	1	0	24	31										A	109577219	G	A	109577219	2	1	68	1	0	0	0	0	0	0	0	1	107	1310	46	2		2	ACACB	12	109577219	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	891292	109577219	24274676	653	21173										
ACAD10	80724	broad.mit.edu	37	chr12	112187122	112187122	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggctgatcgggttctcagaGagggccctggcactcatgaa	14	10	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:112187122G>C	uc001tsq.2	+	18	2990	c.2790G>C	c.(2788-2790)GAG>GAC	p.E930D	ACAD10_uc009zvx.2_Missense_Mutation_p.E961D|ACAD10_uc001tss.1_Intron	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	930							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						GGTTCTCAGAGAGGGCCCTGG	0.617													0	0	0	1	0	11	65										C	112187122	G	C	112187122	3	2	68	1	0	0	0	0	1	0	0	0	108	933	33	1	2953	1	ACAD10	12	112187122	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2609903	112187122	21664773	654	21174										
OAS1	4938	broad.mit.edu	37	chr12	113348980	113348980	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaactacagagagacttcctGaagcagcgccccaccaagct	9	14	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:113348980G>A	uc001tud.2	+	3	700	c.594G>A	c.(592-594)CTG>CTA	p.L198L	OAS1_uc010syn.1_Silent_p.L197L|OAS1_uc010syo.1_Missense_Mutation_p.E182K|OAS1_uc001tub.2_Silent_p.L198L|OAS1_uc001tuc.2_Silent_p.L198L|OAS1_uc009zwf.2_Silent_p.L197L	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	198					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2						GAGACTTCCTGAAGCAGCGCC	0.562													0	0	0	1	0	12	64										A	113348980	G	A	113348980	2	1	68	1	0	0	0	0	0	0	0	1	10799	1277	45	1		1	OAS1	12	113348980	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1161858	113348980	20502915	655	21175										
C12orf43	64897	broad.mit.edu	37	chr12	121454196	121454196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaagccggcattgccgcctCgcggcaccgctccagctcct	10	20	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:121454196C>T	uc001tzh.1	-	1	105	c.82G>A	c.(82-84)GAG>AAG	p.E28K	C12orf43_uc009zxa.1_Missense_Mutation_p.E28K|C12orf43_uc010szo.1_5'UTR|C12orf43_uc010szp.1_Missense_Mutation_p.E28K|C12orf43_uc001tzi.1_Missense_Mutation_p.E28K	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	28											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATTGCCGCCTCGCGGCACCGC	0.637													0	0	0	1	0	18	38										T	121454196	C	T	121454196	3	4	68	1	0	0	0	0	1	0	0	0	1689	893	31	1	730	1	C12orf43	12	121454196	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	8105216	121454196	12397699	656	21176										
CAMKK2	10645	broad.mit.edu	37	chr12	121711915	121711915	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtcggccgccggggcagccGaggcgaggactgcggggagc	21	12	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:121711915G>C	uc001tzu.2	-	2	539	c.415C>G	c.(415-417)CGG>GGG	p.R139G	CAMKK2_uc001tzt.2_Missense_Mutation_p.R139G|CAMKK2_uc001tzv.2_Missense_Mutation_p.R139G|CAMKK2_uc001tzw.2_Missense_Mutation_p.R139G|CAMKK2_uc001tzx.2_Missense_Mutation_p.R139G|CAMKK2_uc001tzy.2_Missense_Mutation_p.R139G|CAMKK2_uc001uaa.1_Missense_Mutation_p.R139G|CAMKK2_uc001uab.2_Missense_Mutation_p.R139G|CAMKK2_uc001uac.2_Missense_Mutation_p.R139G|CAMKK2_uc001uad.1_Missense_Mutation_p.R139G	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	139					calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CGGGGCAGCCGAGGCGAGGAC	0.697													0	0	0	1	0	3	6										C	121711915	G	C	121711915	3	2	68	1	0	0	0	0	1	0	0	0	2607	1057	37	1	1425	1	CAMKK2	12	121711915	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	257719	121711915	12139980	657	21177										
DNAH10	196385	broad.mit.edu	37	chr12	124298139	124298139	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atttcgcttggaaaacttctCaatgagtcagcaaaagagga	9	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:124298139C>A	uc001uft.3	+	19	3244	c.3219C>A	c.(3217-3219)CTC>CTA	p.L1073L	DNAH10_uc010tav.1_Silent_p.L615L|DNAH10_uc010taw.1_Silent_p.L558L	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1073	Stem (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GAAAACTTCTCAATGAGTCAG	0.428													1	0	1.08611e-07	1	1.16965e-07	12	51										A	124298139	C	A	124298139	2	1	68	1	0	0	0	0	0	0	0	1	4598	813	29	3		3	DNAH10	12	124298139	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2586224	124298139	9553756	658	21178										
SCARB1	949	broad.mit.edu	37	chr12	125270804	125270804	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actgctgctggaggtgggctCcaggctgcggttggccagag	18	10	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:125270804C>G	uc001ugo.3	-	11	1753	c.1500G>C	c.(1498-1500)TGG>TGC	p.W500C	SCARB1_uc001ugn.3_Intron|SCARB1_uc001ugm.3_Intron|SCARB1_uc010tbd.1_Intron|SCARB1_uc010tbe.1_Missense_Mutation_p.W459C|SCARB1_uc001ugp.3_Missense_Mutation_p.W500C	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	500	Cytoplasmic (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	GAGGTGGGCTCCAGGCTGCGG	0.672													0	0	0	1	0	8	34										G	125270804	C	G	125270804	3	3	68	1	0	0	0	0	1	0	0	0	13881	870	30	1		1	SCARB1	12	125270804	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	972665	125270804	8581091	659	21179										
RAN	5901	broad.mit.edu	37	chr12	131357396	131357396	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacagcttgtattggttggtGatggtggtactggaaaaacg	14	4	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:131357396G>T	uc001uir.2	+	3	117	c.52G>T	c.(52-54)GAT>TAT	p.D18Y	RAN_uc010tbk.1_5'UTR|RAN_uc010tbl.1_5'UTR|RAN_uc001uis.2_Missense_Mutation_p.D38Y	NM_006325	NP_006316	P62826	RAN_HUMAN	ras-related nuclear protein	18	GTP (By similarity).				androgen receptor signaling pathway|cell division|DNA metabolic process|mitosis|mitotic spindle organization|positive regulation of transcription, DNA-dependent|protein export from nucleus|RNA export from nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|melanosome|nuclear pore|nucleoplasm	androgen receptor binding|chromatin binding|GTP binding|GTPase activity|transcription coactivator activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	Lung NSC(355;7.46e-07)|all_epithelial(31;7.36e-06)		OV - Ovarian serous cystadenocarcinoma(86;9.18e-49)|Epithelial(86;1.42e-45)|all cancers(50;6.28e-40)		ATTGGTTGGTGATGGTGGTAC	0.423													1	0	1.56452e-12	1	1.76009e-12	19	119										T	131357396	G	T	131357396	3	4	68	1	0	0	0	0	1	0	0	0	13024	1290	45	3	58	3	RAN	12	131357396	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6086592	131357396	2494499	660	21180										
DDX51	317781	broad.mit.edu	37	chr12	132625003	132625003	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgttcaaactgcttcaggatCatcctcctctggccaggccc	8	15	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:132625003C>T	uc001ujy.3	-	11	1677	c.1638G>A	c.(1636-1638)ATG>ATA	p.M546I		NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	546	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		GCTTCAGGATCATCCTCCTCT	0.627													0	0	0	1	0	25	69										T	132625003	C	T	132625003	3	4	68	1	0	0	0	0	1	0	0	0	4369	826	29	1	382	1	DDX51	12	132625003	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1267607	132625003	1226892	661	21181										
PXMP2	5827	broad.mit.edu	37	chr12	133277849	133277849	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgcaggggaaagacgcctCagccttcgccgccaagatga	12	12	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr12:133277849C>A	uc001ukt.2	+	4	478	c.413C>A	c.(412-414)TCA>TAA	p.S138*	PGAM5_uc010tbr.1_RNA	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	138	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		AAAGACGCCTCAGCCTTCGCC	0.587													1	0	1.56452e-12	1	1.76009e-12	18	126										A	133277849	C	A	133277849	4	1	68	1	0	0	0	0	0	1	0	0	12850	838	29	3	427	3	PXMP2	12	133277849	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	652846	133277849	574046	662	21182										
EFHA1	221154	broad.mit.edu	37	chr13	22077089	22077089	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctgctgacaacttctctctCacatttttccaataaatatc	2	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:22077089C>G	uc001uof.2	-	9	931	c.909G>C	c.(907-909)GTG>GTC	p.V303V	EFHA1_uc010tct.1_Silent_p.V93V	NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	303	EF-hand 3.						calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		ACTTCTCTCTCACATTTTTCC	0.313													0	0	0	1	0	9	70										G	22077089	C	G	22077089	2	3	68	1	0	0	0	0	0	0	0	1	4943	813	29	1		1	EFHA1	13	22077089	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		22077089	93092789	663	21183										
MIPEP	4285	broad.mit.edu	37	chr13	24460591	24460591	+	Frame_Shift_Del	DEL	C	C	-													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtctttctcaaggctttttCttgtgcaatatgaaatcctt							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:24460591delC	uc001uox.3	-	2	344	c.244delG	c.(244-246)GAAfs	p.E82fs	PCOTH_uc001uoy.2_5'Flank	NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	82					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		AAGGCTTTTTCTTGTGCAATA	0.453																		21	101	---	---								-	24460591	C	-	24460591	7	5	68	1	0	1	0	1	0	0	0	0	9592	922	32	0	1969	0	MIPEP	13	24460591	Frame_Shift_Del	DEL	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2383502	24460591	90709287	664	21184										
SPATA13	221178	broad.mit.edu	37	chr13	24868970	24868970	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagctggagagcatcgacaaGatagctcgctggcaggtgtc	14	9	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:24868970G>C	uc001upg.1	+	9	1706	c.1299G>C	c.(1297-1299)AAG>AAC	p.K433N	SPATA13_uc001upd.1_Missense_Mutation_p.K1058N|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Missense_Mutation_p.K379N|SPATA13_uc010tcz.1_Missense_Mutation_p.K317N|SPATA13_uc010tda.1_Missense_Mutation_p.K377N|SPATA13_uc001uph.2_Missense_Mutation_p.K355N|SPATA13_uc010tdb.1_Missense_Mutation_p.K293N|SPATA13_uc009zzz.1_Intron|SPATA13_uc001upi.1_5'Flank	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	433					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GCATCGACAAGATAGCTCGCT	0.547													0	0	0	1	0	9	57										C	24868970	G	C	24868970	3	2	68	1	0	0	0	0	1	0	0	0	14999	933	33	1	3208	1	SPATA13	13	24868970	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	408379	24868970	90300908	665	21185										
C1QTNF9	338872	broad.mit.edu	37	chr13	24890172	24890172	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtggcttctgcttgccattGaaatctgcacagggaacata	11	9	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:24890172G>A	uc001upj.2	+	2	92	c.31G>A	c.(31-33)GAA>AAA	p.E11K	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	11						collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		GCTTGCCATTGAAATCTGCAC	0.517													0	0	0	1	0	12	97										A	24890172	G	A	24890172	3	1	68	1	0	0	0	0	1	0	0	0	1970	1291	45	1	33	1	C1QTNF9	13	24890172	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	21202	24890172	90279706	666	21186										
ATP12A	479	broad.mit.edu	37	chr13	25266996	25266996	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taacattgtgtaaccgagcaGagttcaagccaggacaggaa	11	8	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:25266996G>A	uc001upp.2	+	10	1526	c.1339G>A	c.(1339-1341)GAG>AAG	p.E447K	ATP12A_uc010aaa.2_Missense_Mutation_p.E453K	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	447	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	TAACCGAGCAGAGTTCAAGCC	0.463													0	0	0	1	0	38	267										A	25266996	G	A	25266996	3	1	68	1	0	0	0	0	1	0	0	0	1122	943	33	1	1395	1	ATP12A	13	25266996	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	376824	25266996	89902882	667	21187										
FAM123A	219287	broad.mit.edu	37	chr13	25744264	25744264	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctccttaggatggggctcGatgggaatccggttgagcct	14	10	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:25744264G>C	uc001uqb.2	-	1	1594	c.1494C>G	c.(1492-1494)ATC>ATG	p.I498M	FAM123A_uc001uqa.2_Missense_Mutation_p.I379M|FAM123A_uc001uqc.2_Missense_Mutation_p.I379M	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	498										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GATGGGGCTCGATGGGAATCC	0.647													0	0	0	1	0	8	62										C	25744264	G	C	25744264	3	2	68	1	0	0	0	0	1	0	0	0	5422	1048	37	1	525	1	FAM123A	13	25744264	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	477268	25744264	89425614	668	21188										
FRY	10129	broad.mit.edu	37	chr13	32811880	32811880	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggagtctgattttgagtttGaatacttaatggccttaagg	11	4	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:32811880G>C	uc001utx.2	+	44	6671	c.6175G>C	c.(6175-6177)GAA>CAA	p.E2059Q	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2059					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTTTGAGTTTGAATACTTAAT	0.498													0	0	0	1	0	12	63										C	32811880	G	C	32811880	3	2	68	1	0	0	0	0	1	0	0	0	6063	1291	45	1	6349	1	FRY	13	32811880	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7067616	32811880	82357998	669	21189										
BRCA2	675	broad.mit.edu	37	chr13	32915107	32915107	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actttttctgatgttcctgtGaaaacaaatatagaagtttg	7	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:32915107G>T	uc001uub.1	+	11	6842	c.6615G>T	c.(6613-6615)GTG>GTT	p.V2205V		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2205					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATGTTCCTGTGAAAACAAATA	0.323			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			1	0	3.67414e-24	1	4.24328e-24	35	80										T	32915107	G	T	32915107	2	4	68	1	0	0	0	0	0	0	0	1	1499	1277	45	3		3	BRCA2	13	32915107	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	103227	32915107	82254771	670	21190										
KL	9365	broad.mit.edu	37	chr13	33628033	33628033	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	accacagcatcaaagaatgtCaaaaatctctggactttgta	6	9	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:33628033C>G	uc001uus.2	+	2	957	c.949C>G	c.(949-951)CAA>GAA	p.Q317E	KL_uc001uur.1_Missense_Mutation_p.Q10E	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	317	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CAAAGAATGTCAAAAATCTCT	0.453													0	0	0	1	0	61	125										G	33628033	C	G	33628033	3	3	68	1	0	0	0	0	1	0	0	0	8331	827	29	1	955	1	KL	13	33628033	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	712926	33628033	81541845	671	21191										
FREM2	341640	broad.mit.edu	37	chr13	39433440	39433440	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtaggcttgcaaccccaaatAttcagactacgataaaacag	7	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:39433440A>G	uc001uwv.2	+	14	7541	c.7232A>G	c.(7231-7233)TAT>TGT	p.Y2411C	FREM2_uc001uww.2_Missense_Mutation_p.Y497C	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2411	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AACCCCAAATATTCAGACTAC	0.483													0	0	0	1	0	33	119										G	39433440	A	G	39433440	3	3	68	1	0	0	0	0	1	0	0	0	6045	449	16	5	7286	5	FREM2	13	39433440	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	5805407	39433440	75736438	672	21192										
MRPS31	10240	broad.mit.edu	37	chr13	41341064	41341064	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccttttcactgtcttggctCtctgaagtctccttggaagt	8	11	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:41341064C>G	uc001uxm.3	-	2	333	c.258G>C	c.(256-258)GAG>GAC	p.E86D		NM_005830	NP_005821	Q92665	RT31_HUMAN	mitochondrial ribosomal protein S31 precursor	86						mitochondrion|ribosome	protein domain specific binding				0		Lung NSC(96;3.55e-06)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;1.52e-08)|Epithelial(112;7.63e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000192)|GBM - Glioblastoma multiforme(144;0.00233)|BRCA - Breast invasive adenocarcinoma(63;0.0706)		TGTCTTGGCTCTCTGAAGTCT	0.373													0	0	0	1	0	28	75										G	41341064	C	G	41341064	3	3	68	1	0	0	0	0	1	0	0	0	9841	912	32	1	953	1	MRPS31	13	41341064	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1907624	41341064	73828814	673	21193										
RB1	5925	broad.mit.edu	37	chr13	48947603	48947603	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcagcaagtgatcaaccttCagaaaatctgatttcctatt	5	9	4	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:48947603C>G	uc001vcb.2	+	12	1356	c.1190C>G	c.(1189-1191)TCA>TGA	p.S397*	RB1_uc010act.1_Nonsense_Mutation_p.S98*	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	397	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)|p.S397fs*1(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATCAACCTTCAGAAAATCTG	0.289		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	1	0	20	172										G	48947603	C	G	48947603	4	3	68	1	0	0	0	0	0	1	0	0	13098	838	29	1	1236	1	RB1	13	48947603	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7606539	48947603	66222275	674	21194										
KLF5	688	broad.mit.edu	37	chr13	73636016	73636016	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tagacaagatgtgaaatggaGaagtatctgacacctcagct	10	7	2	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:73636016G>C	uc001vje.2	+	2	603	c.279G>C	c.(277-279)GAG>GAC	p.E93D	KLF5_uc001vjd.2_Missense_Mutation_p.E2D	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	93					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GTGAAATGGAGAAGTATCTGA	0.408													0	0	0	1	0	21	132										C	73636016	G	C	73636016	3	2	68	1	0	0	0	0	1	0	0	0	8349	933	33	1	285	1	KLF5	13	73636016	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	24688413	73636016	41533862	675	21195										
SCEL	8796	broad.mit.edu	37	chr13	78130748	78130748	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tagagatgaagagcaccactCagggaaccacacggaagcag	12	10	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:78130748C>G	uc001vki.2	+	3	231	c.61C>G	c.(61-63)CAG>GAG	p.Q21E	SCEL_uc001vkj.2_Missense_Mutation_p.Q21E|SCEL_uc010thx.1_Missense_Mutation_p.Q21E	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	21					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		GAGCACCACTCAGGGAACCAC	0.433													0	0	0	1	0	42	260										G	78130748	C	G	78130748	3	3	68	1	0	0	0	0	1	0	0	0	13888	827	29	1	67	1	SCEL	13	78130748	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4494732	78130748	37039130	676	21196										
MBNL2	10150	broad.mit.edu	37	chr13	97986587	97986587	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccgacacacttaaaaactCaactagaaattaatggaagg	6	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:97986587C>T	uc010aft.2	+	3	1048	c.232C>T	c.(232-234)CAA>TAA	p.Q78*	MBNL2_uc001vmz.2_Nonsense_Mutation_p.Q78*|MBNL2_uc001vna.2_Nonsense_Mutation_p.Q78*|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Nonsense_Mutation_p.Q78*	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	78					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			CTTAAAAACTCAACTAGAAAT	0.398													0	0	0	1	0	22	54										T	97986587	C	T	97986587	4	4	68	1	0	0	0	0	0	1	0	0	9354	827	29	1	238	1	MBNL2	13	97986587	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	19855839	97986587	17183291	677	21197										
TPP2	7174	broad.mit.edu	37	chr13	103286425	103286425	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcttcccccaatgcatgtgGaggcattgccctgatccttt	9	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:103286425G>A	uc001vpi.3	+	11	1473	c.1370G>A	c.(1369-1371)GGA>GAA	p.G457E		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	457					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATGCATGTGGAGGCATTGCC	0.453													0	0	0	1	0	21	73										A	103286425	G	A	103286425	3	1	68	1	0	0	0	0	1	0	0	0	16409	1174	41	1	1412	1	TPP2	13	103286425	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5299838	103286425	11883453	678	21198										
C13orf39	196541	broad.mit.edu	37	chr13	103343288	103343288	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacaaatttctggaggctatGaagagatggttctatcttgt	10	5	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:103343288G>A	uc001vpj.2	-	2	163	c.157C>T	c.(157-159)CAT>TAT	p.H53Y	C13orf39_uc001vpk.2_Missense_Mutation_p.H53Y	NM_001010977	NP_001010977	Q5VZV1	MT21C_HUMAN	hypothetical protein LOC196541	53							methyltransferase activity				0						TGGAGGCTATGAAGAGATGGT	0.403													0	0	0	1	0	22	105										A	103343288	G	A	103343288	3	1	68	1	0	0	0	0	1	0	0	0	1732	1290	45	1	649	1	C13orf39	13	103343288	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	56863	103343288	11826590	679	21199										
IRS2	8660	broad.mit.edu	37	chr13	110435129	110435129	+	Frame_Shift_Del	DEL	G	G	-													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgcgggcagcttctggcttcGggggggccgcgataggttgc							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:110435129delG	uc001vqv.2	-	1	3786	c.3272delC	c.(3271-3273)CCGfs	p.P1091fs		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1091					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TTCTGGCTTCGGGGGGGCCGC	0.682																		3	5	---	---								-	110435129	G	-	110435129	7	5	68	1	0	1	0	1	0	0	0	0	7841	1116	39	0	752	0	IRS2	13	110435129	Frame_Shift_Del	DEL	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7091841	110435129	4734749	680	21200										
COL4A2	1284	broad.mit.edu	37	chr13	111156284	111156284	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtgggtccccaggggaggcGaggcccccctggggcaccgg	19	14	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:111156284G>A	uc001vqx.2	+	44	4518	c.4229G>A	c.(4228-4230)CGA>CAA	p.R1410Q		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1410	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CAGGGGAGGCGAGGCCCCCCT	0.731													0	0	0	1	0	11	31										A	111156284	G	A	111156284	3	1	68	1	0	0	0	0	1	0	0	0	3690	1058	37	1	4399	1	COL4A2	13	111156284	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	721155	111156284	4013594	681	21201										
CUL4A	8451	broad.mit.edu	37	chr13	113887597	113887597	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcgagcgcgagaggagcggcGaggccgtggaccggagcctg	20	11	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:113887597G>A	uc010tjy.1	+	7	630	c.619G>A	c.(619-621)GAG>AAG	p.E207K	CUL4A_uc010tjx.1_Missense_Mutation_p.E107K|CUL4A_uc010agu.2_Missense_Mutation_p.E68K|CUL4A_uc001vtl.1_5'Flank	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	207					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GAGGAGCGGCGAGGCCGTGGA	0.542													0	0	0	1	0	10	57										A	113887597	G	A	113887597	3	1	68	1	0	0	0	0	1	0	0	0	4057	1059	37	1	641	1	CUL4A	13	113887597	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2731313	113887597	1282281	682	21202										
RASA3	22821	broad.mit.edu	37	chr13	114765114	114765114	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccactgccaggatgttctCgatgggaatgctgtagagag	13	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr13:114765114C>T	uc001vui.2	-	20	2010	c.1879G>A	c.(1879-1881)GAG>AAG	p.E627K	RASA3_uc010tkk.1_Missense_Mutation_p.E595K|RASA3_uc001vuj.2_Missense_Mutation_p.E244K	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	627	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			AGGATGTTCTCGATGGGAATG	0.622													0	0	0	1	0	5	47										T	114765114	C	T	114765114	3	4	68	1	0	0	0	0	1	0	0	0	13062	893	31	1	645	1	RASA3	13	114765114	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	877517	114765114	404764	683	21203										
TMEM55B	90809	broad.mit.edu	37	chr14	20928361	20928361	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcctcttaccagtagggccGagggcatgcaatccgttggg	14	11	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:20928361G>T	uc001vxl.2	-	3	583	c.430C>A	c.(430-432)CGG>AGG	p.R144R	TMEM55B_uc001vxk.2_Silent_p.R151R	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	144						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		CAGTAGGGCCGAGGGCATGCA	0.488													1	0	4.26978e-12	1	4.79067e-12	23	32										T	20928361	G	T	20928361	2	4	68	1	0	0	0	0	0	0	0	1	16179	1057	37	3		3	TMEM55B	14	20928361	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		20928361	86421179	684	21204										
METTL3	56339	broad.mit.edu	37	chr14	21979365	21979365	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agagctccacgtgtccgacaTcctagtctcccagccctgac	8	17	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:21979365T>C	uc001wbc.2	-	1	93	c.1A>G	c.(1-3)ATG>GTG	p.M1V	METTL3_uc010tlw.1_RNA|METTL3_uc010tlx.1_Missense_Mutation_p.M1V|METTL3_uc001wbd.1_Missense_Mutation_p.M1V	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	1					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		GTGTCCGACATCCTAGTCTCC	0.632													0	0	0	1	0	5	12										C	21979365	T	C	21979365	3	2	68	1	0	0	0	0	1	0	0	0	9501	1435	50	5	1785	5	METTL3	14	21979365	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	1051004	21979365	85370175	685	21205										
C14orf106	55320	broad.mit.edu	37	chr14	45693438	45693438	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttttcttaacttcagctttCcttttaatttccttttctgt	3	9	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:45693438C>T	uc001wwf.2	-	11	2811	c.2352G>A	c.(2350-2352)AGG>AGA	p.R784R		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	784					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						CTTCAGCTTTCCTTTTAATTT	0.358													0	0	0	1	0	34	48										T	45693438	C	T	45693438	2	4	68	1	0	0	0	0	0	0	0	1	1738	854	30	1		1	C14orf106	14	45693438	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	23714073	45693438	61656102	686	21206										
POLE2	5427	broad.mit.edu	37	chr14	50117145	50117145	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcagatgtccttgggataaGatagtctttacaaactacaa	8	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:50117145G>T	uc001wwu.2	-	17	1349	c.1335C>A	c.(1333-1335)ATC>ATA	p.I445I	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Silent_p.I159I|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Silent_p.I160I	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	445					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTTGGGATAAGATAGTCTTTA	0.358													1	0	2.35188e-11	1	2.62477e-11	19	55										T	50117145	G	T	50117145	2	4	68	1	0	0	0	0	0	0	0	1	12197	932	33	3		3	POLE2	14	50117145	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4423707	50117145	57232395	687	21207										
PSMC6	5706	broad.mit.edu	37	chr14	53178177	53178177	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttataacatgtctcatgagGaccctgggaatgtttcttat	8	7	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:53178177G>A	uc010tqx.1	+	6	418	c.418G>A	c.(418-420)GAC>AAC	p.D140N	PSMC6_uc010tqw.1_Missense_Mutation_p.D106N	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	126					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					GTCTCATGAGGACCCTGGGAA	0.393													0	0	0	1	0	48	62										A	53178177	G	A	53178177	3	1	68	1	0	0	0	0	1	0	0	0	12691	1174	41	1	440	1	PSMC6	14	53178177	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3061032	53178177	54171363	688	21208										
C14orf135	64430	broad.mit.edu	37	chr14	60591695	60591695	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgagctcgttatttccagaaGactggtaccaatttgttcta	8	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:60591695G>C	uc001xer.3	+	8	2626	c.2104G>C	c.(2104-2106)GAC>CAC	p.D702H	C14orf135_uc001xeq.2_Missense_Mutation_p.D702H|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	936						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		ATTTCCAGAAGACTGGTACCA	0.413													0	0	0	1	0	31	69										C	60591695	G	C	60591695	3	2	68	1	0	0	0	0	1	0	0	0	1745	942	33	1	2130	1	C14orf135	14	60591695	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7413518	60591695	46757845	689	21209										
C14orf50	145376	broad.mit.edu	37	chr14	65041219	65041219	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aattggttttaagtgaattaGaagcagcacagaggtacttg	11	4	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:65041219G>C	uc001xhl.1	+	8	676	c.580G>C	c.(580-582)GAA>CAA	p.E194Q		NM_172365	NP_758953	Q96LQ0	CN050_HUMAN	hypothetical protein LOC145376	194										skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)		AAGTGAATTAGAAGCAGCACA	0.433													0	0	0	1	0	16	51										C	65041219	G	C	65041219	3	2	68	1	0	0	0	0	1	0	0	0	1777	943	33	1	610	1	C14orf50	14	65041219	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4449524	65041219	42308321	690	21210										
SIPA1L1	26037	broad.mit.edu	37	chr14	72200447	72200447	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acccgcaggcagcctatgccCgaccctggcctgatgcccct	10	19	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:72200447C>T	uc001xms.2	+	19	5337	c.4989C>T	c.(4987-4989)CCC>CCT	p.P1663P	SIPA1L1_uc001xmt.2_Silent_p.P1642P|SIPA1L1_uc001xmu.2_Silent_p.P1642P|SIPA1L1_uc001xmv.2_Silent_p.P1663P|SIPA1L1_uc010ttm.1_Silent_p.P1117P|SIPA1L1_uc001xmw.2_Silent_p.P428P	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1663					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AGCCTATGCCCGACCCTGGCC	0.587													0	0	0	1	0	13	23										T	72200447	C	T	72200447	2	4	68	1	0	0	0	0	0	0	0	1	14329	639	23	2		2	SIPA1L1	14	72200447	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7159228	72200447	35149093	691	21211										
RBM25	58517	broad.mit.edu	37	chr14	73581010	73581010	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttaggttatggctcatagttCaccccagagcattttagatg	9	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:73581010C>T	uc001xno.2	+	18	2616	c.2408C>T	c.(2407-2409)TCA>TTA	p.S803L	RBM25_uc010ttu.1_Missense_Mutation_p.S803L|RBM25_uc001xnp.2_Missense_Mutation_p.S598L	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	803	PWI.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		GCTCATAGTTCACCCCAGAGC	0.219													0	0	0	1	0	42	71										T	73581010	C	T	73581010	3	4	68	1	0	0	0	0	1	0	0	0	13125	838	29	1	2474	1	RBM25	14	73581010	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1380563	73581010	33768530	692	21212										
PAPLN	89932	broad.mit.edu	37	chr14	73712862	73712862	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttccaggggcggcggtatCggtggctgccctactacagc	15	12	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:73712862C>T	uc010ttx.1	+	4	476	c.313C>T	c.(313-315)CGG>TGG	p.R105W	PAPLN_uc001xnw.3_Missense_Mutation_p.R105W|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.R105W|uc001xnx.2_5'Flank	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	105						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCGGCGGTATCGGTGGCTGCC	0.667													0	0	0	1	0	3	9										T	73712862	C	T	73712862	3	4	68	1	0	0	0	0	1	0	0	0	11428	875	31	1	327	1	PAPLN	14	73712862	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	131852	73712862	33636678	693	21213										
ACOT2	10965	broad.mit.edu	37	chr14	74036029	74036029	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctcatctcctgctgtccttCgagcgtcccggctgtaccaa	8	17	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:74036029C>G	uc001xon.3	+	1	258	c.85C>G	c.(85-87)CGA>GGA	p.R29G	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_5'UTR	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	29					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		TGCTGTCCTTCGAGCGTCCCG	0.557													0	0	0	1	0	63	56										G	74036029	C	G	74036029	3	3	68	1	0	0	0	0	1	0	0	0	152	876	31	1	87	1	ACOT2	14	74036029	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	323167	74036029	33313511	694	21214										
DLST	1743	broad.mit.edu	37	chr14	75359643	75359643	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagcacccatacccactcaGatgccaccggtgccctcgcc	8	20	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:75359643G>C	uc001xqv.2	+	8	612	c.549G>C	c.(547-549)CAG>CAC	p.Q183H	DLST_uc001xqu.2_Missense_Mutation_p.Q95H|DLST_uc001xqt.2_Missense_Mutation_p.Q99H|DLST_uc010tuw.1_Missense_Mutation_p.Q97H|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.Q183H	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	183					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		TACCCACTCAGATGCCACCGG	0.587													0	0	0	1	0	9	61										C	75359643	G	C	75359643	3	2	68	1	0	0	0	0	1	0	0	0	4569	933	33	1	579	1	DLST	14	75359643	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1323614	75359643	31989897	695	21215										
EIF2B2	8892	broad.mit.edu	37	chr14	75470262	75470262	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgcctctatagactccatgGacgcagcgacgagagtgatc	11	11	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:75470262G>A	uc001xrc.1	+	3	375	c.293G>A	c.(292-294)GGA>GAA	p.G98E		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	98				RLHGRSD -> DSMDAAT (in Ref. 2; AAC42002).	cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		AGACTCCATGGACGCAGCGAC	0.537													0	0	0	1	0	44	49										A	75470262	G	A	75470262	3	1	68	1	0	0	0	0	1	0	0	0	5001	1174	41	1	303	1	EIF2B2	14	75470262	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	110619	75470262	31879278	696	21216										
EIF2B2	8892	broad.mit.edu	37	chr14	75475859	75475859	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acatctaccgcctgatgagtGaactctaccatcctgatgat	7	12	2	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:75475859G>A	uc001xrc.1	+	8	1106	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	342					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		CCTGATGAGTGAACTCTACCA	0.473													0	0	0	1	0	49	291										A	75475859	G	A	75475859	3	1	68	1	0	0	0	0	1	0	0	0	5001	1291	45	1	1054	1	EIF2B2	14	75475859	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5597	75475859	31873681	697	21217										
FLVCR2	55640	broad.mit.edu	37	chr14	76045894	76045894	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgctctgtggcccaggttttCatcctgggcatgccctcccg	11	15	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:76045894C>T	uc001xrs.2	+	1	955	c.579C>T	c.(577-579)TTC>TTT	p.F193F		NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	193	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		CCCAGGTTTTCATCCTGGGCA	0.602													0	0	0	1	0	54	63										T	76045894	C	T	76045894	2	4	68	1	0	0	0	0	0	0	0	1	5946	825	29	1		1	FLVCR2	14	76045894	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	570035	76045894	31303646	698	21218										
TMEM63C	57156	broad.mit.edu	37	chr14	77712285	77712285	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctctgtttccttctagatCaagtcagaatctggtcatgg	8	10	6	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:77712285C>G	uc001xtf.2	+	17	1663	c.1451C>G	c.(1450-1452)TCA>TGA	p.S484*	TMEM63C_uc010asq.1_Nonsense_Mutation_p.S484*	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	484						integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		CCTTCTAGATCAAGTCAGAAT	0.418													0	0	0	1	0	12	160										G	77712285	C	G	77712285	4	3	68	1	0	0	0	0	0	1	0	0	16189	838	29	1	1509	1	TMEM63C	14	77712285	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1666391	77712285	29637255	699	21219										
FAM181A	90050	broad.mit.edu	37	chr14	94394796	94394796	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcccagaagtattcccggctCccgcggggccttcctggcag	12	16	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:94394796C>A	uc001ybz.1	+	3	658	c.351C>A	c.(349-351)CTC>CTA	p.L117L	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.L55L|FAM181A_uc001yca.1_Silent_p.L55L	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	117											0						ATTCCCGGCTCCCGCGGGGCC	0.647													1	0	1.3612e-06	1	1.44492e-06	16	19										A	94394796	C	A	94394796	2	1	68	1	0	0	0	0	0	0	0	1	5508	842	30	3		3	FAM181A	14	94394796	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	16682511	94394796	12954744	700	21220										
GSC	145258	broad.mit.edu	37	chr14	95234906	95234906	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcgacgacgacgtcttgttCcacttctccgcgttctccga	8	15	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:95234906C>T	uc001ydu.2	-	3	843	c.696G>A	c.(694-696)TGG>TGA	p.W232*		NM_173849	NP_776248	P56915	GSC_HUMAN	goosecoid	232					gastrulation|middle ear morphogenesis		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(154;0.0896)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.202)|Epithelial(152;0.239)		ACGTCTTGTTCCACTTCTCCG	0.597													0	0	0	1	0	24	178										T	95234906	C	T	95234906	4	4	68	1	0	0	0	0	0	1	0	0	6814	856	30	1	81	1	GSC	14	95234906	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	840110	95234906	12114634	701	21221										
ATG2B	55102	broad.mit.edu	37	chr14	96792138	96792138	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcctctttcttgatcagatCgaagatcaggtattgggaag	11	7	4	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:96792138C>T	uc001yfi.2	-	15	2650	c.2285G>A	c.(2284-2286)CGA>CAA	p.R762Q		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	762										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TTGATCAGATCGAAGATCAGG	0.383													0	0	0	1	0	37	118										T	96792138	C	T	96792138	3	4	68	1	0	0	0	0	1	0	0	0	1094	884	31	1	4063	1	ATG2B	14	96792138	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1557232	96792138	10557402	702	21222										
ATG2B	55102	broad.mit.edu	37	chr14	96807901	96807901	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctgtttcaacgtgagactCaactccaacctaccaattaa	4	12	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:96807901C>T	uc001yfi.2	-	6	1247	c.882G>A	c.(880-882)TTG>TTA	p.L294L		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	294										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ACGTGAGACTCAACTCCAACC	0.388													0	0	0	1	0	83	84										T	96807901	C	T	96807901	2	4	68	1	0	0	0	0	0	0	0	1	1094	825	29	1		1	ATG2B	14	96807901	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	15763	96807901	10541639	703	21223										
AK7	122481	broad.mit.edu	37	chr14	96944839	96944839	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatgcttcggatgagtttctGaaggagcgtgtgataaacct	13	6	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:96944839G>A	uc001yfn.2	+	15	1637	c.1593G>A	c.(1591-1593)CTG>CTA	p.L531L		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	531					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		ATGAGTTTCTGAAGGAGCGTG	0.542													0	0	0	1	0	22	164										A	96944839	G	A	96944839	2	1	68	1	0	0	0	0	0	0	0	1	444	1277	45	1		1	AK7	14	96944839	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	136938	96944839	10404701	704	21224										
PAPOLA	10914	broad.mit.edu	37	chr14	97009217	97009217	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtcatttccagcacccaaaGaaaatcccgacaagtaagcc	6	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:97009217G>A	uc001yfq.2	+	14	1486	c.1276G>A	c.(1276-1278)GAA>AAA	p.E426K	PAPOLA_uc001yfr.2_Missense_Mutation_p.E426K|PAPOLA_uc010twv.1_Missense_Mutation_p.E426K|PAPOLA_uc010avp.2_Missense_Mutation_p.E176K	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	426					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AGCACCCAAAGAAAATCCCGA	0.358													0	0	0	1	0	23	194										A	97009217	G	A	97009217	3	1	68	1	0	0	0	0	1	0	0	0	11429	943	33	1	1330	1	PAPOLA	14	97009217	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	64378	97009217	10340323	705	21225										
RTL1	388015	broad.mit.edu	37	chr14	101348170	101348170	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctcggccgccgtcttgttCtggcagctccatgacgtcaa	11	14	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:101348170C>T	uc010txj.1	-	1	3015	c.2956G>A	c.(2956-2958)GAA>AAA	p.E986K	MIR433_hsa-mir-433|MI0001723_5'Flank|uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	986										pancreas(1)	1						CCGTCTTGTTCTGGCAGCTCC	0.582													0	0	0	1	0	22	140										T	101348170	C	T	101348170	3	4	68	1	0	0	0	0	1	0	0	0	13724	922	32	1	1124	1	RTL1	14	101348170	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4338953	101348170	6001370	706	21226										
XRCC3	7517	broad.mit.edu	37	chr14	104165273	104165273	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agggcagcctcttcctcgcgGagccggtcagccagcagtct	13	15	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:104165273G>T	uc001yny.3	-	10	1283	c.903C>A	c.(901-903)CTC>CTA	p.L301L	KLC1_uc010tyf.1_Intron|KLC1_uc001yno.2_Intron|KLC1_uc001yns.2_Intron|XRCC3_uc001ynx.3_Silent_p.L301L|XRCC3_uc001ynz.3_Silent_p.L301L|XRCC3_uc001yoa.3_Silent_p.L301L	NM_005432	NP_005423	O43542	XRCC3_HUMAN	X-ray repair cross complementing protein 3	301					DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		CTTCCTCGCGGAGCCGGTCAG	0.657								Direct_reversal_of_damage|Homologous_recombination					1	0	4.68919e-08	1	5.05854e-08	11	12										T	104165273	G	T	104165273	2	4	68	1	0	0	0	0	0	0	0	1	17451	1161	41	3		3	XRCC3	14	104165273	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2817103	104165273	3184267	707	21227										
PPP1R13B	23368	broad.mit.edu	37	chr14	104201510	104201510	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcaggcgagtgttcgctgtCggggtttgatccgtggatac	15	8	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:104201510C>T	uc001yof.1	-	17	3537	c.3254G>A	c.(3253-3255)CGA>CAA	p.R1085Q	PPP1R13B_uc010awv.1_RNA	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	1085					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TGTTCGCTGTCGGGGTTTGAT	0.577													0	0	0	1	0	13	78										T	104201510	C	T	104201510	3	4	68	1	0	0	0	0	1	0	0	0	12357	884	31	1	22	1	PPP1R13B	14	104201510	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	36237	104201510	3148030	708	21228										
TDRD9	122402	broad.mit.edu	37	chr14	104464977	104464977	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagttatagatttttgtttGactagaactttggtctgtga	10	4	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:104464977G>C	uc001yom.3	+	13	1425	c.1395G>C	c.(1393-1395)TTG>TTC	p.L465F	TDRD9_uc001yon.3_Missense_Mutation_p.L203F	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	465	Helicase C-terminal.				cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATTTTTGTTTGACTAGAACTT	0.338													0	0	0	1	0	44	122										C	104464977	G	C	104464977	3	2	68	1	0	0	0	0	1	0	0	0	15733	1281	45	1	1445	1	TDRD9	14	104464977	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	263467	104464977	2884563	709	21229										
MTA1	9112	broad.mit.edu	37	chr14	105927222	105927222	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggaggagtggtctgcatcaGaggccaaccttttcgaggaa	14	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr14:105927222G>C	uc001yqx.2	+	10	1061	c.874G>C	c.(874-876)GAG>CAG	p.E292Q	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Missense_Mutation_p.E206Q|MTA1_uc001yra.1_Missense_Mutation_p.E206Q|MTA1_uc001yrb.2_Missense_Mutation_p.E53Q	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	292	SANT.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GTCTGCATCAGAGGCCAACCT	0.577													0	0	0	1	0	17	51										C	105927222	G	C	105927222	3	2	68	1	0	0	0	0	1	0	0	0	9908	943	33	1	912	1	MTA1	14	105927222	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1462245	105927222	1422318	710	21230										
FMN1	342184	broad.mit.edu	37	chr15	33359341	33359341	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gataccaacactcgaattctGgtttgttactgcaggtaggt	10	8	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:33359341G>A	uc001zhf.3	-	1	745	c.745C>T	c.(745-747)CAG>TAG	p.Q249*	FMN1_uc001zhg.2_Nonsense_Mutation_p.Q249*	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTCGAATTCTGGTTTGTTACT	0.507													0	0	0	1	0	37	80										A	33359341	G	A	33359341	4	1	68	1	0	0	0	0	0	1	0	0	5949	1357	47	2	2913	2	FMN1	15	33359341	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		33359341	69172051	711	21231										
C15orf55	256646	broad.mit.edu	37	chr15	34649344	34649344	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggaagaggatgaggaactCtccaactttgcttacctctt	10	9	2	2	rs7163178		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:34649344C>T	uc001zif.2	+	7	3206	c.3051C>T	c.(3049-3051)CTC>CTT	p.L1017L	C15orf55_uc010ucc.1_Silent_p.L1045L|C15orf55_uc010ucd.1_Silent_p.L1035L	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	1017						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		ATGAGGAACTCTCCAACTTTG	0.502			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	1	0	13	50										T	34649344	C	T	34649344	2	4	68	1	0	0	0	0	0	0	0	1	1803	900	32	1		1	C15orf55	15	34649344	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1290003	34649344	67882048	712	21232										
CASC5	57082	broad.mit.edu	37	chr15	40913088	40913088	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgtggatcaaaacacttcttCagaaaataaaatagatttca	5	7	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:40913088C>T	uc010bbs.1	+	11	865	c.704C>T	c.(703-705)TCA>TTA	p.S235L	CASC5_uc010ucq.1_Missense_Mutation_p.S59L|CASC5_uc001zme.2_Missense_Mutation_p.S209L|CASC5_uc010bbt.1_Missense_Mutation_p.S209L	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	235	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AACACTTCTTCAGAAAATAAA	0.308													0	0	0	1	0	10	49										T	40913088	C	T	40913088	3	4	68	1	0	0	0	0	1	0	0	0	2663	838	29	1	742	1	CASC5	15	40913088	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6263744	40913088	61618304	713	21233										
FAM82A2	55177	broad.mit.edu	37	chr15	41044242	41044242	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgcttctcagctcctccaCctcccgccgcagcgccacaa	7	21	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:41044242C>A	uc001zmo.1	-	3	466	c.322G>T	c.(322-324)GTG>TTG	p.V108L	FAM82A2_uc001zmp.1_Missense_Mutation_p.V108L|FAM82A2_uc001zmq.1_Missense_Mutation_p.V108L	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	108	Potential.				apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						AGCTCCTCCACCTCCCGCCGC	0.632													1	0	3.09899e-07	1	3.31189e-07	7	81										A	41044242	C	A	41044242	3	1	68	1	0	0	0	0	1	0	0	0	5631	507	18	4	1134	4	FAM82A2	15	41044242	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	131154	41044242	61487150	714	21234										
MGA	23269	broad.mit.edu	37	chr15	42046702	42046702	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgagactgtagaagagctctCagaggaaattaatgttgctc	11	6	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:42046702C>T	uc010ucy.1	+	18	7257	c.7076C>T	c.(7075-7077)TCA>TTA	p.S2359L	MGA_uc010ucz.1_Missense_Mutation_p.S2150L|MGA_uc010uda.1_Missense_Mutation_p.S975L	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2320	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAAGAGCTCTCAGAGGAAATT	0.383													0	0	0	1	0	3	5										T	42046702	C	T	42046702	3	4	68	1	0	0	0	0	1	0	0	0	9540	838	29	1	7142	1	MGA	15	42046702	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1002460	42046702	60484690	715	21235										
MGA	23269	broad.mit.edu	37	chr15	42046722	42046722	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagaggaaattaatgttgctCacctgaagaccacagcggcc	10	11	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:42046722C>T	uc010ucy.1	+	18	7277	c.7096C>T	c.(7096-7098)CAC>TAC	p.H2366Y	MGA_uc010ucz.1_Missense_Mutation_p.H2157Y|MGA_uc010uda.1_Missense_Mutation_p.H982Y	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2327	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TAATGTTGCTCACCTGAAGAC	0.398													0	0	0	1	0	3	4										T	42046722	C	T	42046722	3	4	68	1	0	0	0	0	1	0	0	0	9540	826	29	1	7162	1	MGA	15	42046722	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	20	42046722	60484670	716	21236										
SPTBN5	51332	broad.mit.edu	37	chr15	42185575	42185575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttgcgaatgtggcccgtctCgtactgagagtccatggtga	13	10	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:42185575C>T	uc001zos.2	-	2	349	c.16G>A	c.(16-18)GAG>AAG	p.E6K	uc010bcp.1_RNA	NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	41	Actin-binding.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TGGCCCGTCTCGTACTGAGAG	0.622													0	0	0	1	0	7	31										T	42185575	C	T	42185575	3	4	68	1	0	0	0	0	1	0	0	0	15121	893	31	1	11171	1	SPTBN5	15	42185575	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	138853	42185575	60345817	717	21237										
TP53BP1	7158	broad.mit.edu	37	chr15	43739643	43739643	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcaccagtcaatggtgggatGatatcaccttctttaggcaa	10	9	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:43739643G>A	uc001zrs.2	-	13	2890	c.2742C>T	c.(2740-2742)ATC>ATT	p.I914I	TP53BP1_uc010udp.1_Silent_p.I914I|TP53BP1_uc001zrq.3_Silent_p.I919I|TP53BP1_uc001zrr.3_Silent_p.I919I|TP53BP1_uc010udq.1_Silent_p.I919I	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	914					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		ATGGTGGGATGATATCACCTT	0.323								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	1	0	32	59										A	43739643	G	A	43739643	2	1	68	1	0	0	0	0	0	0	0	1	16380	1280	45	1		1	TP53BP1	15	43739643	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1554068	43739643	58791749	718	21238										
MAP1A	4130	broad.mit.edu	37	chr15	43814035	43814035	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agggctctagcagttacagcGactgggtgaagaaccttatc	12	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:43814035G>A	uc001zrt.2	+	4	831	c.364G>A	c.(364-366)GAC>AAC	p.D122N		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	122						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAGTTACAGCGACTGGGTGAA	0.552													0	0	0	1	0	22	70										A	43814035	G	A	43814035	3	1	68	1	0	0	0	0	1	0	0	0	9227	1058	37	1	366	1	MAP1A	15	43814035	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	74392	43814035	58717357	719	21239										
EIF3J	8669	broad.mit.edu	37	chr15	44849735	44849735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgctatgaacccatcttcaaGagatgactttacagagtttg	8	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:44849735G>C	uc001ztv.2	+	6	585	c.458G>C	c.(457-459)AGA>ACA	p.R153T	EIF3J_uc010ueg.1_Intron|EIF3J_uc001ztw.2_Missense_Mutation_p.R104T	NM_003758	NP_003749	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3,	153						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		CCATCTTCAAGAGATGACTTT	0.318													0	0	0	1	0	14	58										C	44849735	G	C	44849735	3	2	68	1	0	0	0	0	1	0	0	0	5020	942	33	1	480	1	EIF3J	15	44849735	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1035700	44849735	57681657	720	21240										
SPG11	80208	broad.mit.edu	37	chr15	44900791	44900791	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaacagttttcattttcttCattctgaacaacctaagtaa	3	9	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:44900791C>A	uc001ztx.2	-	19	3335	c.3304G>T	c.(3304-3306)GAA>TAA	p.E1102*	SPG11_uc010ueh.1_Nonsense_Mutation_p.E1102*|SPG11_uc010uei.1_Nonsense_Mutation_p.E1102*	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1102	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCATTTTCTTCATTCTGAACA	0.373													1	0	0.184627	1	0.184921	5	28										A	44900791	C	A	44900791	4	1	68	1	0	0	0	0	0	1	0	0	15040	835	29	3	4115	3	SPG11	15	44900791	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	51056	44900791	57630601	721	21241										
DUOX1	53905	broad.mit.edu	37	chr15	45424173	45424173	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attattttcatcatgggcttCtgcctggctctagcatggac	9	10	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:45424173C>T	uc001zus.1	+	3	355	c.9C>T	c.(7-9)TTC>TTT	p.F3F	DUOXA1_uc001zup.2_5'Flank|DUOXA1_uc010bec.2_5'Flank|DUOXA1_uc001zur.1_5'Flank|DUOXA1_uc010bed.1_5'Flank|DUOX1_uc001zut.1_Silent_p.F3F|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	3					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TCATGGGCTTCTGCCTGGCTC	0.507													0	0	0	1	0	16	66										T	45424173	C	T	45424173	2	4	68	1	0	0	0	0	0	0	0	1	4800	912	32	1		1	DUOX1	15	45424173	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	523382	45424173	57107219	722	21242										
FBN1	2200	broad.mit.edu	37	chr15	48720649	48720649	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctcacagatccctggcttCgtctgacattcattctcatc	5	14	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:48720649C>T	uc001zwx.1	-	57	7219	c.6891G>A	c.(6889-6891)ACG>ACA	p.T2297T	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2297	EGF-like 40; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TCCCTGGCTTCGTCTGACATT	0.448													0	0	0	1	0	6	39										T	48720649	C	T	48720649	2	4	68	1	0	0	0	0	0	0	0	1	5702	871	31	1		1	FBN1	15	48720649	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3296476	48720649	53810743	723	21243										
FBN1	2200	broad.mit.edu	37	chr15	48791227	48791227	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccactgctgcagagtgcctGatattccgctgcaataaatt	8	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:48791227G>C	uc001zwx.1	-	18	2450	c.2122C>G	c.(2122-2124)CAG>GAG	p.Q708E		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	708	TB 3.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CAGAGTGCCTGATATTCCGCT	0.453													0	0	0	1	0	22	105										C	48791227	G	C	48791227	3	2	68	1	0	0	0	0	1	0	0	0	5702	1299	45	1	6689	1	FBN1	15	48791227	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	70578	48791227	53740165	724	21244										
ONECUT1	3175	broad.mit.edu	37	chr15	53081808	53081808	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctcatacctgggggagtctCgcaggccatggtcatggtgg	16	10	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:53081808C>A	uc002aci.1	-	1	402	c.274G>T	c.(274-276)GAG>TAG	p.E92*		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	92					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		GGGGGAGTCTCGCAGGCCATG	0.657													1	0	3.09899e-07	1	3.31189e-07	9	12										A	53081808	C	A	53081808	4	1	68	1	0	0	0	0	0	1	0	0	10868	893	31	3	1131	3	ONECUT1	15	53081808	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4290581	53081808	49449584	725	21245										
IGDCC4	57722	broad.mit.edu	37	chr15	65687479	65687479	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggtggaggtgcggctggctCccagctgggagtaggccacc	19	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:65687479C>T	uc002aou.1	-	8	1739	c.1529G>A	c.(1528-1530)GGA>GAA	p.G510E	IGDCC4_uc002aot.1_Missense_Mutation_p.G98E	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	510	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GCGGCTGGCTCCCAGCTGGGA	0.567													0	0	0	1	0	9	28										T	65687479	C	T	65687479	3	4	68	1	0	0	0	0	1	0	0	0	7569	855	30	1	2275	1	IGDCC4	15	65687479	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	12605671	65687479	36843913	726	21246										
ITGA11	22801	broad.mit.edu	37	chr15	68596209	68596209	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgccagtcctcttgcttggaGatctcaaacacgatctgcaa	8	12	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:68596209G>T	uc002ari.2	-	29	3483	c.3396C>A	c.(3394-3396)ATC>ATA	p.I1132I	ITGA11_uc010bib.2_Silent_p.I1133I	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	1132	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CTTGCTTGGAGATCTCAAACA	0.637													1	0	5.50884e-06	1	5.79878e-06	12	49										T	68596209	G	T	68596209	2	4	68	1	0	0	0	0	0	0	0	1	7874	932	33	3		3	ITGA11	15	68596209	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2908730	68596209	33935183	727	21247										
TLE3	7090	broad.mit.edu	37	chr15	70347433	70347433	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcttgctgcctggctggctGatgtcccagatcttcacgca	10	14	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:70347433G>T	uc002asm.2	-	15	2661	c.1542C>A	c.(1540-1542)ATC>ATA	p.I514I	TLE3_uc002ask.2_Silent_p.I441I|TLE3_uc002asl.2_Silent_p.I514I|TLE3_uc010ukd.1_Silent_p.I504I|TLE3_uc010bik.1_Silent_p.I95I|TLE3_uc010bil.1_Silent_p.I511I|TLE3_uc002asn.2_Silent_p.I502I|TLE3_uc002asp.2_Silent_p.I506I|TLE3_uc002aso.2_Silent_p.I509I	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	514	WD 1.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						CTGGCTGGCTGATGTCCCAGA	0.632													1	0	0.00116845	1	0.00119403	6	17										T	70347433	G	T	70347433	2	4	68	1	0	0	0	0	0	0	0	1	15937	1280	45	3		3	TLE3	15	70347433	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1751224	70347433	32183959	728	21248										
NEO1	4756	broad.mit.edu	37	chr15	73409170	73409170	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagagtcttggaactattatCagtagaacagcgaagctcat	10	7	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:73409170C>T	uc002avm.3	+	2	562	c.420C>T	c.(418-420)ATC>ATT	p.I140I	NEO1_uc010ukx.1_Silent_p.I140I|NEO1_uc010uky.1_Silent_p.I140I|NEO1_uc010ukz.1_5'UTR	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	140	Extracellular (Potential).|Ig-like C2-type 1.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						GAACTATTATCAGTAGAACAG	0.333													0	0	0	1	0	19	73										T	73409170	C	T	73409170	2	4	68	1	0	0	0	0	0	0	0	1	10336	816	29	1		1	NEO1	15	73409170	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3061737	73409170	29122222	729	21249										
UBL7	84993	broad.mit.edu	37	chr15	74749005	74749005	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttagcttccgaccacagtaGatcagatctaaaaaaagaac	6	9	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:74749005G>T	uc002axw.1	-	3	354	c.192C>A	c.(190-192)ATC>ATA	p.I64I	UBL7_uc002axx.1_Silent_p.I104I|UBL7_uc010bjr.1_Intron|UBL7_uc002axy.1_Silent_p.I64I|UBL7_uc002axz.1_Silent_p.I64I	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	64	Ubiquitin-like.						protein binding			ovary(1)	1						GACCACAGTAGATCAGATCTA	0.418													1	0	0.000151284	1	0.000156888	12	87										T	74749005	G	T	74749005	2	4	68	1	0	0	0	0	0	0	0	1	16887	932	33	3		3	UBL7	15	74749005	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1339835	74749005	27782387	730	21250										
UBL7	84993	broad.mit.edu	37	chr15	74751198	74751198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcaccgccaggtgccagtctGagagagacatcctctctctt	9	14	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:74751198G>A	uc002axw.1	-	2	173	c.11C>T	c.(10-12)TCA>TTA	p.S4L	UBL7_uc002axx.1_Missense_Mutation_p.S44L|UBL7_uc010bjr.1_Intron|UBL7_uc002axy.1_Missense_Mutation_p.S4L|UBL7_uc002axz.1_Missense_Mutation_p.S4L|uc002aya.2_5'Flank|uc002ayb.2_5'Flank	NM_032907	NP_116296	Q96S82	UBL7_HUMAN	ubiquitin-like 7	4							protein binding			ovary(1)	1						GTGCCAGTCTGAGAGAGACAT	0.527													0	0	0	1	0	23	106										A	74751198	G	A	74751198	3	1	68	1	0	0	0	0	1	0	0	0	16887	1294	45	1	1171	1	UBL7	15	74751198	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2193	74751198	27780194	731	21251										
SCAPER	49855	broad.mit.edu	37	chr15	77057793	77057793	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attttggcgccaagactcacGagctgttcagaaaaaaatac	8	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:77057793G>A	uc002bby.2	-	12	1557	c.1498C>T	c.(1498-1500)CGT>TGT	p.R500C	SCAPER_uc002bbx.2_Missense_Mutation_p.R254C|SCAPER_uc002bbz.1_Missense_Mutation_p.R371C|SCAPER_uc002bca.1_Missense_Mutation_p.R365C|SCAPER_uc002bcb.1_Missense_Mutation_p.R506C|SCAPER_uc002bcc.1_Missense_Mutation_p.R500C	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	499	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						CAAGACTCACGAGCTGTTCAG	0.393													0	0	0	1	0	16	34										A	77057793	G	A	77057793	3	1	68	1	0	0	0	0	1	0	0	0	13878	1058	37	1	2784	1	SCAPER	15	77057793	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2306595	77057793	25473599	732	21252										
SH2D7	646892	broad.mit.edu	37	chr15	78386496	78386496	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gacaaagctcttggttccttCcttatccgcctcagtgaccg	8	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:78386496C>T	uc010blb.1	+	2	219	c.219C>T	c.(217-219)TTC>TTT	p.F73F		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	73	SH2.										0						TTGGTTCCTTCCTTATCCGCC	0.567													0	0	0	1	0	3	10										T	78386496	C	T	78386496	2	4	68	1	0	0	0	0	0	0	0	1	14239	854	30	1		1	SH2D7	15	78386496	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1328703	78386496	24144896	733	21253										
FAH	2184	broad.mit.edu	37	chr15	80465456	80465456	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggtgcccatggatgctctCatgccctttgctgtgcccaa	11	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:80465456C>T	uc002bfj.2	+	10	889	c.807C>T	c.(805-807)CTC>CTT	p.L269L	FAH_uc002bfk.1_Silent_p.L269L|FAH_uc002bfm.1_Silent_p.L269L|FAH_uc002bfn.1_Silent_p.L199L	NM_000137	NP_000128	P16930	FAAA_HUMAN	fumarylacetoacetase	269					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding				0						TGGATGCTCTCATGCCCTTTG	0.577									Tyrosinemia_type_1		OREG0023354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	37	87										T	80465456	C	T	80465456	2	4	68	1	0	0	0	0	0	0	0	1	5371	813	29	1		1	FAH	15	80465456	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2078960	80465456	22065936	734	21254										
ALPK3	57538	broad.mit.edu	37	chr15	85400425	85400425	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtgggaggagagagatgccGagggccacagtcatcaggcc	18	9	2	2	rs116079740	by1000genomes	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:85400425G>A	uc002ble.2	+	6	3229	c.3062G>A	c.(3061-3063)CGA>CAA	p.R1021Q		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1021					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GAGAGATGCCGAGGGCCACAG	0.647													0	0	0	1	0	5	46										A	85400425	G	A	85400425	3	1	68	1	0	0	0	0	1	0	0	0	546	1058	37	1	3084	1	ALPK3	15	85400425	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4934969	85400425	17130967	735	21255										
ACAN	176	broad.mit.edu	37	chr15	89382250	89382250	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcatggcatcgaggacagcGaggccaccctggaagtcgtg	15	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:89382250G>A	uc010upo.1	+	3	801	c.427G>A	c.(427-429)GAG>AAG	p.E143K	ACAN_uc002bmx.2_Missense_Mutation_p.E143K|ACAN_uc010upp.1_Missense_Mutation_p.E143K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	143					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CGAGGACAGCGAGGCCACCCT	0.622													0	0	0	1	0	22	95										A	89382250	G	A	89382250	3	1	68	1	0	0	0	0	1	0	0	0	117	1059	37	1	433	1	ACAN	15	89382250	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3981825	89382250	13149142	736	21256										
POLG	5428	broad.mit.edu	37	chr15	89867416	89867416	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggggcatcagctgctgcttCccctgttcgagacagtgctt	12	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:89867416C>A	uc002bns.3	-	11	2274	c.1992G>T	c.(1990-1992)GGG>GGT	p.G664G	POLG_uc002bnr.3_Silent_p.G664G	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	664					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			GCTGCTGCTTCCCCTGTTCGA	0.502								DNA_polymerases_(catalytic_subunits)					1	0	0.000157383	1	0.00016281	8	52										A	89867416	C	A	89867416	2	1	68	1	0	0	0	0	0	0	0	1	12200	842	30	3		3	POLG	15	89867416	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	485166	89867416	12663976	737	21257										
C15orf42	90381	broad.mit.edu	37	chr15	90127692	90127692	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctaggaagtccagaggagagCacagcaactcaaaggctgtt	12	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:90127692C>G	uc002boe.2	+	3	1110	c.1110C>G	c.(1108-1110)AGC>AGG	p.S370R		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	370					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CAGAGGAGAGCACAGCAACTC	0.502													0	0	0	1	0	17	63										G	90127692	C	G	90127692	3	3	68	1	0	0	0	0	1	0	0	0	1796	709	25	4	1120	4	C15orf42	15	90127692	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	260276	90127692	12403700	738	21258										
UNC45A	55898	broad.mit.edu	37	chr15	91483662	91483662	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgacctcatgctggcggctCtgcgtacgctggttggcatt	13	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:91483662C>T	uc002bqg.2	+	6	986	c.646C>T	c.(646-648)CTG>TTG	p.L216L	UNC45A_uc002bqd.2_Silent_p.L201L|UNC45A_uc010uqo.1_Silent_p.L208L|UNC45A_uc010uqp.1_RNA|UNC45A_uc010uqq.1_Silent_p.L216L	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	216					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCTGGCGGCTCTGCGTACGCT	0.532													0	0	0	1	0	16	59										T	91483662	C	T	91483662	2	4	68	1	0	0	0	0	0	0	0	1	16985	912	32	1		1	UNC45A	15	91483662	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1355970	91483662	11047730	739	21259										
RGMA	56963	broad.mit.edu	37	chr15	93595352	93595352	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggaagcggtcggtgaaagtCctgaggtgtgggtccccgaa	17	8	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:93595352C>T	uc002bss.1	-	3	788	c.516G>A	c.(514-516)AGG>AGA	p.R172R	RGMA_uc002bsq.1_Silent_p.R156R|RGMA_uc010boi.1_Silent_p.R63R|RGMA_uc002bsr.1_Silent_p.R63R|RGMA_uc010urc.1_Silent_p.R180R	NM_020211	NP_064596	Q96B86	RGMA_HUMAN	RGM domain family, member A precursor	172					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane					0	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			CGGTGAAAGTCCTGAGGTGTG	0.602													0	0	0	1	0	6	19										T	93595352	C	T	93595352	2	4	68	1	0	0	0	0	0	0	0	1	13280	854	30	1		1	RGMA	15	93595352	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2111690	93595352	8936040	740	21260										
SYNM	23336	broad.mit.edu	37	chr15	99672778	99672778	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagatcctttaggcacattCgactaggtcctacagaaacg	9	11	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr15:99672778C>T	uc002bup.2	+	6	4333	c.4213C>T	c.(4213-4215)CGA>TGA	p.R1405*	SYNM_uc002buo.2_Intron|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1405	Tail.|Interaction with DMD and UTRN.|Interaction with TLN1 and VCL.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TAGGCACATTCGACTAGGTCC	0.517													0	0	0	1	0	49	172										T	99672778	C	T	99672778	4	4	68	1	0	0	0	0	0	1	0	0	15452	876	31	1	4226	1	SYNM	15	99672778	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6077426	99672778	2858614	741	21261										
RHBDF1	64285	broad.mit.edu	37	chr16	109026	109026	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggttgccggtgacaccactCagcaggtagatgatggctat	13	9	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:109026C>T	uc002cfl.3	-	20	2242	c.2094G>A	c.(2092-2094)CTG>CTA	p.L698L		NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	698	Helical; (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				TGACACCACTCAGCAGGTAGA	0.617													0	0	0	1	0	7	77										T	109026	C	T	109026	2	4	68	1	0	0	0	0	0	0	0	1	13319	813	29	1		1	RHBDF1	16	109026	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		109026	90245727	742	21262										
RHBDF1	64285	broad.mit.edu	37	chr16	113674	113674	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttgtcctggctgggcaggtCcagctcccggaggacctggg	17	12	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:113674C>T	uc002cfl.3	-	7	521	c.373G>A	c.(373-375)GAC>AAC	p.D125N	RHBDF1_uc010uty.1_Missense_Mutation_p.D148N|RHBDF1_uc010utz.1_Missense_Mutation_p.D125N|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	125	Cytoplasmic (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				CTGGGCAGGTCCAGCTCCCGG	0.647													0	0	0	1	0	15	45										T	113674	C	T	113674	3	4	68	1	0	0	0	0	1	0	0	0	13319	855	30	1	2254	1	RHBDF1	16	113674	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4648	113674	90241079	743	21263										
WDR24	84219	broad.mit.edu	37	chr16	735939	735939	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgtgcatctcctttgctgcgGtccagccgcgtctcactgcc	10	17	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:735939G>C	uc002ciz.1	-	5	2263	c.1503C>G	c.(1501-1503)GAC>GAG	p.D501E	JMJD8_uc002ciw.1_5'Flank|JMJD8_uc002cix.1_5'Flank|JMJD8_uc002ciy.1_5'Flank	NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	631										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				CTTTGCTGCGGTCCAGCCGCG	0.642													0	0	0	1	0	16	118										C	735939	G	C	735939	3	2	68	1	0	0	0	0	1	0	0	0	17278	1252	44	4	889	4	WDR24	16	735939	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	622265	735939	89618814	744	21264										
TELO2	9894	broad.mit.edu	37	chr16	1544331	1544331	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcgccgtccgggaagccattCatgccctctcgtcttcggag	11	15	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:1544331C>G	uc002cly.2	+	2	340	c.49C>G	c.(49-51)CAT>GAT	p.H17D	TELO2_uc010uvg.1_Missense_Mutation_p.H17D	NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	17						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				GGAAGCCATTCATGCCCTCTC	0.622											OREG0023547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	61	120										G	1544331	C	G	1544331	3	3	68	1	0	0	0	0	1	0	0	0	15754	826	29	1	51	1	TELO2	16	1544331	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	808392	1544331	88810422	745	21265										
RPS2	6187	broad.mit.edu	37	chr16	2012818	2012818	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acgatggagagcttggccagGatgatggccccacggatggc	16	10	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:2012818G>A	uc002cnn.2	-	4	656	c.468C>T	c.(466-468)ATC>ATT	p.I156I	RPS2_uc010bsa.1_RNA|RPS2_uc002cnl.2_Intron|RPS2_uc002cnm.2_Intron|RPS2_uc002cno.2_Silent_p.I156I|SNORA10_uc002cnp.1_5'Flank|SNHG9_uc002cnr.2_5'Flank|SNORA78_uc002cns.1_5'Flank	NM_002952	NP_002943	P15880	RS2_HUMAN	ribosomal protein S2	156	S5 DRBM.				endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	fibroblast growth factor 1 binding|fibroblast growth factor 3 binding|RNA binding|structural constituent of ribosome				0						GCTTGGCCAGGATGATGGCCC	0.607													0	0	0	1	0	8	38										A	2012818	G	A	2012818	2	1	68	1	0	0	0	0	0	0	0	1	13631	1164	41	1		1	RPS2	16	2012818	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	468487	2012818	88341935	746	21266										
NTHL1	4913	broad.mit.edu	37	chr16	2090035	2090035	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caccaagagtccattgatctCgtgccacagctccctgtggg	10	14	1	2	rs71716587		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:2090035C>A	uc002col.1	-	6	848	c.829G>T	c.(829-831)GAG>TAG	p.E277*	NTHL1_uc002com.1_Nonsense_Mutation_p.E278*	NM_002528	NP_002519	P78549	NTHL1_HUMAN	nth endonuclease III-like 1	277					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						CCATTGATCTCGTGCCACAGC	0.662								BER_DNA_glycosylases					1	0	1.16021e-09	1	1.28009e-09	28	71										A	2090035	C	A	2090035	4	1	68	1	0	0	0	0	0	1	0	0	10698	893	31	3	113	3	NTHL1	16	2090035	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	77217	2090035	88264718	747	21267										
CASKIN1	57524	broad.mit.edu	37	chr16	2237188	2237188	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcgcaacagctgcttgatctCcctgctggcctgggacgtgg	13	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:2237188C>A	uc010bsg.1	-	8	846	c.814G>T	c.(814-816)GAG>TAG	p.E272*		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	272					signal transduction	cytoplasm				skin(2)	2						TGCTTGATCTCCCTGCTGGCC	0.667													1	0	1.5842e-08	1	1.72077e-08	14	53										A	2237188	C	A	2237188	4	1	68	1	0	0	0	0	0	1	0	0	2666	864	30	3	3533	3	CASKIN1	16	2237188	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	147153	2237188	88117565	748	21268										
DNASE1L2	1775	broad.mit.edu	37	chr16	2286829	2286829	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccgcgccatgggcgggccCcgggctctgctggccgcact	15	18	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:2286829C>T	uc002cpo.2	+	1	406	c.12C>T	c.(10-12)CCC>CCT	p.P4P	DNASE1L2_uc002cpn.2_Silent_p.P4P|DNASE1L2_uc002cpp.2_Silent_p.P4P|DNASE1L2_uc002cpq.2_Silent_p.P4P	NM_001374	NP_001365	Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2 precursor	4					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding				0						TGGGCGGGCCCCGGGCTCTGC	0.706													0	0	0	1	0	4	9										T	2286829	C	T	2286829	2	4	68	1	0	0	0	0	0	0	0	1	4662	610	22	2		2	DNASE1L2	16	2286829	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	49641	2286829	88067924	749	21269										
SRRM2	23524	broad.mit.edu	37	chr16	2808485	2808485	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccctagccttgttcgggagtCtagcagttctcgctcaccaa	9	14	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:2808485C>G	uc002crk.2	+	5	1079	c.530C>G	c.(529-531)TCT>TGT	p.S177C	SRRM2_uc002crj.1_Missense_Mutation_p.S81C|SRRM2_uc002crl.1_Missense_Mutation_p.S177C|SRRM2_uc010bsu.1_Missense_Mutation_p.S81C	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	177	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GTTCGGGAGTCTAGCAGTTCT	0.363													0	0	0	1	0	22	188										G	2808485	C	G	2808485	3	3	68	1	0	0	0	0	1	0	0	0	15168	913	32	1	544	1	SRRM2	16	2808485	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	521656	2808485	87546268	750	21270										
DNAJA3	9093	broad.mit.edu	37	chr16	4500496	4500496	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cggcgtcaccctcaccagctCtggtaaggagtctgaagact	11	13	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:4500496C>G	uc002cwk.2	+	10	1362	c.1337C>G	c.(1336-1338)TCT>TGT	p.S446C	DNAJA3_uc002cwl.2_Missense_Mutation_p.S446C|DNAJA3_uc010uxk.1_Missense_Mutation_p.S293C	NM_005147	NP_005138	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	446					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			ovary(2)|breast(2)	4						CTCACCAGCTCTGGTAAGGAG	0.607													0	0	0	1	0	5	8										G	4500496	C	G	4500496	3	3	68	1	0	0	0	0	1	0	0	0	4613	913	32	1	1375	1	DNAJA3	16	4500496	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1692011	4500496	85854257	751	21271										
PPL	5493	broad.mit.edu	37	chr16	4933533	4933533	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acttcctgtcgtgtatcactGaggactccccattgggaccc	9	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:4933533G>C	uc002cyd.1	-	22	5213	c.5123C>G	c.(5122-5124)TCA>TGA	p.S1708*		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1708	Plectin 2.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GTGTATCACTGAGGACTCCCC	0.557													0	0	0	1	0	20	57										C	4933533	G	C	4933533	4	2	68	1	0	0	0	0	0	1	0	0	12334	1294	45	1	151	1	PPL	16	4933533	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	433037	4933533	85421220	752	21272										
FAM18A	780776	broad.mit.edu	37	chr16	10911962	10911962	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctccatcccaacacacctGatcttggctttcctaaaggc	6	15	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:10911962G>A	uc010buo.1	-	2	358	c.87C>T	c.(85-87)ATC>ATT	p.I29I	FAM18A_uc010uyr.1_RNA|FAM18A_uc010uys.1_RNA|FAM18A_uc010uyt.1_RNA|FAM18A_uc010bun.2_RNA|FAM18A_uc010uyu.1_RNA|FAM18A_uc002dad.3_Intron|FAM18A_uc002daf.1_RNA	NM_001079512	NP_001072980	A6NH52	FA18A_HUMAN	hypothetical protein LOC780776	29						integral to membrane					0						CAACACACCTGATCTTGGCTT	0.428													0	0	0	1	0	3	10										A	10911962	G	A	10911962	2	1	68	1	0	0	0	0	0	0	0	1	5518	1280	45	1		1	FAM18A	16	10911962	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5978429	10911962	79442791	753	21273										
CLEC16A	23274	broad.mit.edu	37	chr16	11145494	11145494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcgatgtggagaagacccGgcgggtgagtgagcacagga	19	7	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:11145494G>A	uc002dao.2	+	18	2221	c.1991G>A	c.(1990-1992)CGG>CAG	p.R664Q	CLEC16A_uc002dan.3_Missense_Mutation_p.R646Q	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	664										ovary(1)|central_nervous_system(1)	2						GAGAAGACCCGGCGGGTGAGT	0.602													0	0	0	1	0	17	83										A	11145494	G	A	11145494	3	1	68	1	0	0	0	0	1	0	0	0	3500	1116	39	2	2057	2	CLEC16A	16	11145494	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	233532	11145494	79209259	754	21274										
NOMO1	23420	broad.mit.edu	37	chr16	14958467	14958467	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggttcctgaggcagaaaccaGagcagggctgacgttgaaac	14	9	0	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:14958467G>C	uc002dcv.2	+	13	1487	c.1421G>C	c.(1420-1422)AGA>ACA	p.R474T		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	474	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						GCAGAAACCAGAGCAGGGCTG	0.532													0	0	0	1	0	74	212										C	14958467	G	C	14958467	3	2	68	1	0	0	0	0	1	0	0	0	10531	942	33	1	1471	1	NOMO1	16	14958467	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3812973	14958467	75396286	755	21275										
ABCC1	4363	broad.mit.edu	37	chr16	16103752	16103752	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcccaactctcttgggcatCaccatggtaagtaggagctg	11	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:16103752C>G	uc010bvi.2	+	3	520	c.345C>G	c.(343-345)ATC>ATG	p.I115M	ABCC1_uc010bvj.2_Missense_Mutation_p.I115M|ABCC1_uc010bvk.2_Missense_Mutation_p.I115M|ABCC1_uc010bvl.2_Missense_Mutation_p.I115M|ABCC1_uc010bvm.2_Missense_Mutation_p.I115M|ABCC1_uc002del.3_Translation_Start_Site	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	115	Helical; Name=3.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCTTGGGCATCACCATGGTAA	0.507													0	0	0	1	0	19	75										G	16103752	C	G	16103752	3	3	68	1	0	0	0	0	1	0	0	0	49	816	29	1	355	1	ABCC1	16	16103752	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1145285	16103752	74251001	756	21276										
DNAH3	55567	broad.mit.edu	37	chr16	20976008	20976008	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gatacaatgatgccattgtcGatggagaaggagtcaacggg	14	6	1	2	rs61746919	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:20976008G>C	uc010vbe.1	-	53	9198	c.9198C>G	c.(9196-9198)ATC>ATG	p.I3066M	DNAH3_uc010vbd.1_Missense_Mutation_p.I501M	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3066	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGCCATTGTCGATGGAGAAGG	0.502													0	0	0	1	0	16	70										C	20976008	G	C	20976008	3	2	68	1	0	0	0	0	1	0	0	0	4603	1048	37	1	3191	1	DNAH3	16	20976008	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4872256	20976008	69378745	757	21277										
DNAH3	55567	broad.mit.edu	37	chr16	20996973	20996973	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttctggcttgaaataatctCcaaagaagaggcttcgaatg	9	7	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:20996973C>T	uc010vbe.1	-	48	7091	c.7091G>A	c.(7090-7092)GGA>GAA	p.G2364E	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2364					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GAAATAATCTCCAAAGAAGAG	0.433													0	0	0	1	0	42	112										T	20996973	C	T	20996973	3	4	68	1	0	0	0	0	1	0	0	0	4603	855	30	1	5318	1	DNAH3	16	20996973	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	20965	20996973	69357780	758	21278										
DNAH3	55567	broad.mit.edu	37	chr16	21115865	21115865	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctgttgtcaaagatatcttCaatctggtctggccagagga	11	8	5	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:21115865C>A	uc010vbe.1	-	16	2293	c.2293G>T	c.(2293-2295)GAA>TAA	p.E765*	DNAH3_uc002die.2_Nonsense_Mutation_p.E719*	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	765	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AAGATATCTTCAATCTGGTCT	0.478													1	0	6.68952e-21	1	7.69753e-21	48	117										A	21115865	C	A	21115865	4	1	68	1	0	0	0	0	0	1	0	0	4603	835	29	3	10244	3	DNAH3	16	21115865	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	118892	21115865	69238888	759	21279										
EEF2K	29904	broad.mit.edu	37	chr16	22291646	22291646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgatgctggccagggaggccGagatgctgttcacaggaggc	17	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:22291646G>A	uc002dki.2	+	17	2502	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	673					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		CAGGGAGGCCGAGATGCTGTT	0.637													0	0	0	1	0	9	44										A	22291646	G	A	22291646	3	1	68	1	0	0	0	0	1	0	0	0	4930	1059	37	1	2079	1	EEF2K	16	22291646	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1175781	22291646	68063107	760	21280										
USP31	57478	broad.mit.edu	37	chr16	23119406	23119406	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctgcttcactgaatggttGaggtcttcatgaactcggtc	10	10	4	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:23119406G>C	uc002dll.2	-	2	732	c.732C>G	c.(730-732)CTC>CTG	p.L244L		NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	244					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CTGAATGGTTGAGGTCTTCAT	0.512													0	0	0	1	0	20	46										C	23119406	G	C	23119406	2	2	68	1	0	0	0	0	0	0	0	1	17059	1277	45	1		1	USP31	16	23119406	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	827760	23119406	67235347	761	21281										
UBFD1	56061	broad.mit.edu	37	chr16	23581875	23581875	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actcaatatgtggatgcaatCaaagacactgtgctggggaa	11	7	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:23581875C>G	uc002dlv.2	+	7	1096	c.894C>G	c.(892-894)ATC>ATG	p.I298M		NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	298											0				GBM - Glioblastoma multiforme(48;0.0331)		TGGATGCAATCAAAGACACTG	0.512													0	0	0	1	0	20	120										G	23581875	C	G	23581875	3	3	68	1	0	0	0	0	1	0	0	0	16881	816	29	1	920	1	UBFD1	16	23581875	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	462469	23581875	66772878	762	21282										
RBBP6	5930	broad.mit.edu	37	chr16	24566966	24566966	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggctgaagccaatgcttctGaagaagataaaattaaagca	9	6	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:24566966G>A	uc002dmh.2	+	5	1419	c.379G>A	c.(379-381)GAA>AAA	p.E127K	RBBP6_uc010vcb.1_5'UTR|RBBP6_uc002dmi.2_Missense_Mutation_p.E127K|RBBP6_uc010bxr.2_Missense_Mutation_p.E127K|RBBP6_uc002dmk.2_5'UTR	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	127					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		CAATGCTTCTGAAGAAGATAA	0.363													0	0	0	1	0	21	120										A	24566966	G	A	24566966	3	1	68	1	0	0	0	0	1	0	0	0	13103	1291	45	1	451	1	RBBP6	16	24566966	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	985091	24566966	65787787	763	21283										
ZKSCAN2	342357	broad.mit.edu	37	chr16	25251684	25251684	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtctgatcaggctcctgcttCtaccaaagcacttcccacag	7	15	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:25251684C>T	uc002dod.3	-	7	2764	c.2357G>A	c.(2356-2358)AGA>AAA	p.R786K	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.R582K	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	786	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		GCTCCTGCTTCTACCAAAGCA	0.453													0	0	0	1	0	15	68										T	25251684	C	T	25251684	3	4	68	1	0	0	0	0	1	0	0	0	17684	913	32	1	550	1	ZKSCAN2	16	25251684	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	684718	25251684	65103069	764	21284										
IL21R	50615	broad.mit.edu	37	chr16	27456503	27456503	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgcttccttcccagagttaAaggaaggctggaaccctcac	9	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:27456503A>G	uc002doq.1	+	7	924	c.691A>G	c.(691-693)AAG>GAG	p.K231E	IL21R_uc002dor.1_Missense_Mutation_p.K231E|IL21R_uc002dos.1_Missense_Mutation_p.K231E	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	231	Extracellular (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CCCAGAGTTAAAGGAAGGCTG	0.532			T	BCL6	NHL								0	0	0	1	0	11	31										G	27456503	A	G	27456503	3	3	68	1	0	0	0	0	1	0	0	0	7671	15	1	5	713	5	IL21R	16	27456503	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2204819	27456503	62898250	765	21285										
SBK1	388228	broad.mit.edu	37	chr16	28331409	28331409	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccgcaggtggggctccctGaggacacggtgaagcgctgt	17	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:28331409G>T	uc002dpd.2	+	4	1231	c.442G>T	c.(442-444)GAG>TAG	p.E148*		NM_001024401	NP_001019572	Q52WX2	SBK1_HUMAN	SH3-binding kinase 1	148	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|kidney(1)	2						GGGGCTCCCTGAGGACACGGT	0.711													1	0	0.184627	1	0.184921	4	12										T	28331409	G	T	28331409	4	4	68	1	0	0	0	0	0	1	0	0	13860	1291	45	3	452	3	SBK1	16	28331409	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	874906	28331409	62023344	766	21286										
MVP	9961	broad.mit.edu	37	chr16	29852916	29852916	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctccctgtcctcgtcccaaGgtgcgcgctgtgattggaag	12	14	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:29852916G>A	uc002dui.2	+	9	1276	c.1192_splice	c.e9-1	p.V398_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_Splice_Site|MVP_uc002duj.2_Splice_Site_p.V398_splice|MVP_uc010vea.1_Splice_Site	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein						mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CTCGTCCCAAGGTGCGCGCTG	0.637													0	0	0	1	0	9	28										A	29852916	G	A	29852916	5	1	68	1	0	0	0	0	0	0	1	0	9996	1014	35	2	1221	2	MVP	16	29852916	Splice_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1521507	29852916	60501837	767	21287										
ALDOA	226	broad.mit.edu	37	chr16	30078815	30078815	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccattggcaccgagaacaccGaggagaaccggcgcttctac	11	14	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:30078815G>A	uc002dvw.2	+	6	1285	c.157G>A	c.(157-159)GAG>AAG	p.E53K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ALDOA_uc002dvx.2_Missense_Mutation_p.E53K|ALDOA_uc002dvy.2_Missense_Mutation_p.E53K|ALDOA_uc002dvz.2_Missense_Mutation_p.E53K|ALDOA_uc002dwa.3_Missense_Mutation_p.E53K|ALDOA_uc002dwb.1_Missense_Mutation_p.E53K|ALDOA_uc002dwc.2_Missense_Mutation_p.E53K|ALDOA_uc010veg.1_Missense_Mutation_p.E107K|ALDOA_uc002dwd.2_Missense_Mutation_p.E53K	NM_184043	NP_908932	P04075	ALDOA_HUMAN	fructose-bisphosphate aldolase A	53					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			lung(1)	1						CGAGAACACCGAGGAGAACCG	0.607													0	0	0	1	0	9	48										A	30078815	G	A	30078815	3	1	68	1	0	0	0	0	1	0	0	0	507	1059	37	1	163	1	ALDOA	16	30078815	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	225899	30078815	60275938	768	21288										
ZNF688	146542	broad.mit.edu	37	chr16	30581606	30581606	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggtcccaggcagcatttttGggtggctgtgcccgtgccgg	17	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:30581606G>C	uc002dyt.2	-	3	1240	c.462C>G	c.(460-462)CCC>CCG	p.P154P	ZNF688_uc002dys.2_Silent_p.P140P|uc002dyu.2_5'Flank	NM_145271	NP_660314	P0C7X2	ZN688_HUMAN	zinc finger protein 688 isoform a	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAGCATTTTTGGGTGGCTGTG	0.647													0	0	0	1	0	9	29										C	30581606	G	C	30581606	2	2	68	1	0	0	0	0	0	0	0	1	18090	1335	47	4		4	ZNF688	16	30581606	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	502791	30581606	59773147	769	21289										
ZNF688	146542	broad.mit.edu	37	chr16	30581750	30581750	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctcttccttcctgtttggGacatctcctgggaaaccgga	9	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:30581750G>T	uc002dyt.2	-	3	1096	c.318C>A	c.(316-318)GTC>GTA	p.V106V	ZNF688_uc002dys.2_Silent_p.V92V|uc002dyu.2_5'Flank	NM_145271	NP_660314	P0C7X2	ZN688_HUMAN	zinc finger protein 688 isoform a	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCTGTTTGGGACATCTCCTG	0.488													1	0	6.53275e-17	1	7.46262e-17	13	57										T	30581750	G	T	30581750	2	4	68	1	0	0	0	0	0	0	0	1	18090	1161	41	3		3	ZNF688	16	30581750	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	144	30581750	59773003	770	21290										
SRCAP	10847	broad.mit.edu	37	chr16	30732788	30732788	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tatctcccgatatgcaggctCgcctgccctgtaagttccca	8	15	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:30732788C>T	uc002dze.1	+	21	3917	c.3532C>T	c.(3532-3534)CGC>TGC	p.R1178C	SRCAP_uc002dzf.2_Intron|SRCAP_uc002dzg.1_Missense_Mutation_p.R1035C|SRCAP_uc010bzz.1_Missense_Mutation_p.R748C	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1178	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TATGCAGGCTCGCCTGCCCTG	0.552													0	0	0	1	0	8	51										T	30732788	C	T	30732788	3	4	68	1	0	0	0	0	1	0	0	0	15134	884	31	1	3606	1	SRCAP	16	30732788	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	151038	30732788	59621965	771	21291										
ZNF629	23361	broad.mit.edu	37	chr16	30795476	30795476	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctccagggacatctctgttGagtccttggattctggactc	10	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:30795476G>C	uc002dzs.1	-	3	381	c.173C>G	c.(172-174)TCA>TGA	p.S58*		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CATCTCTGTTGAGTCCTTGGA	0.597													0	0	0	1	0	4	15										C	30795476	G	C	30795476	4	2	68	1	0	0	0	0	0	1	0	0	18050	1294	45	1	2440	1	ZNF629	16	30795476	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	62688	30795476	59559277	772	21292										
FBXL19	54620	broad.mit.edu	37	chr16	30953717	30953717	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctgcaggagctggtgctctCtggctgctcctggctctctg	13	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:30953717C>G	uc002eab.2	+	9	1705	c.1547C>G	c.(1546-1548)TCT>TGT	p.S516C	FBXL19_uc002dzz.1_Missense_Mutation_p.S204C|FBXL19_uc002eaa.1_Missense_Mutation_p.S415C	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	516	LRR 1.						DNA binding|zinc ion binding	p.E516K(1)		ovary(2)|lung(1)|breast(1)	4						CTGGTGCTCTCTGGCTGCTCC	0.662											OREG0023741	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	16										G	30953717	C	G	30953717	3	3	68	1	0	0	0	0	1	0	0	0	5715	913	32	1	1581	1	FBXL19	16	30953717	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	158241	30953717	59401036	773	21293										
TRIM72	493829	broad.mit.edu	37	chr16	31235662	31235662	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggtggcgcaccagcagctCtccgagggcgagcactactg	15	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:31235662C>G	uc002ebn.1	+	7	1249	c.1020C>G	c.(1018-1020)CTC>CTG	p.L340L	uc002ebp.1_5'Flank	NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	340	B30.2/SPRY.				exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						ACCAGCAGCTCTCCGAGGGCG	0.622													0	0	0	1	0	5	11										G	31235662	C	G	31235662	2	3	68	1	0	0	0	0	0	0	0	1	16542	900	32	1		1	TRIM72	16	31235662	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	281945	31235662	59119091	774	21294										
LONP2	83752	broad.mit.edu	37	chr16	48286111	48286111	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagccccactacactctgttGattacaggcctatgccgttt	7	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:48286111G>A	uc002efi.1	+	2	392	c.303G>A	c.(301-303)TTG>TTA	p.L101L	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Silent_p.L101L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	101	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						ACACTCTGTTGATTACAGGCC	0.488													0	0	0	1	0	7	54										A	48286111	G	A	48286111	2	1	68	1	0	0	0	0	0	0	0	1	8893	1281	45	1		1	LONP2	16	48286111	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	17050449	48286111	42068642	775	21295										
CHD9	80205	broad.mit.edu	37	chr16	53288467	53288467	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagtttgaaactgggcctaGataaagctgtgttacagagc	11	8	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:53288467G>A	uc002ehb.2	+	17	4143	c.3979G>A	c.(3979-3981)GAT>AAT	p.D1327N	CHD9_uc002egy.2_Missense_Mutation_p.D1327N|CHD9_uc002ehc.2_Missense_Mutation_p.D1327N|CHD9_uc002ehf.2_Missense_Mutation_p.D441N|CHD9_uc002ehd.2_Missense_Mutation_p.D853N	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1327	Helicase C-terminal.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACTGGGCCTAGATAAAGCTGT	0.388													0	0	0	1	0	34	258										A	53288467	G	A	53288467	3	1	68	1	0	0	0	0	1	0	0	0	3332	942	33	1	4045	1	CHD9	16	53288467	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5002356	53288467	37066286	776	21296										
GPR114	221188	broad.mit.edu	37	chr16	57608778	57608778	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcctggtcatgggctacggCggcctcacgtccctcttcaa	11	15	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:57608778C>T	uc002elx.3	+	11	1345	c.1260C>T	c.(1258-1260)GGC>GGT	p.G420G	GPR114_uc010vhr.1_Missense_Mutation_p.A381V|GPR114_uc002ely.2_Silent_p.G420G	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	420	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						TGGGCTACGGCGGCCTCACGT	0.701													0	0	0	1	0	8	57										T	57608778	C	T	57608778	2	4	68	1	0	0	0	0	0	0	0	1	6631	755	27	2		2	GPR114	16	57608778	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4320311	57608778	32745975	777	21297										
KATNB1	10300	broad.mit.edu	37	chr16	57787356	57787356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagcagcgaggatgaccggGacgagcgcgagtcccgcgcg	17	14	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:57787356G>A	uc002eml.1	+	12	1476	c.1102G>A	c.(1102-1104)GAC>AAC	p.D368N		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	368	Interaction with PAFAH1B1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				GGATGACCGGGACGAGCGCGA	0.667													0	0	0	1	0	21	42										A	57787356	G	A	57787356	3	1	68	1	0	0	0	0	1	0	0	0	7987	1174	41	1	1144	1	KATNB1	16	57787356	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	178578	57787356	32567397	778	21298										
CNOT1	23019	broad.mit.edu	37	chr16	58592477	58592477	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctggtgactgaggggtactGaatgcagaacccaaatttgg	14	7	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:58592477G>C	uc002env.2	-	18	2525	c.2232C>G	c.(2230-2232)TTC>TTG	p.F744L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.F744L|CNOT1_uc002enx.2_Missense_Mutation_p.F744L|CNOT1_uc002enz.1_Missense_Mutation_p.F173L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	744					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GAGGGGTACTGAATGCAGAAC	0.493													0	0	0	1	0	10	54										C	58592477	G	C	58592477	3	2	68	1	0	0	0	0	1	0	0	0	3617	1281	45	1	5248	1	CNOT1	16	58592477	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	805121	58592477	31762276	779	21299										
CNOT1	23019	broad.mit.edu	37	chr16	58608559	58608559	+	Missense_Mutation	SNP	G	G	T													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cattgtcgccaaagtttctgGaggaagttgagcacttttgg							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:58608559G>T	uc002env.2	-	16	2226	c.1933C>A	c.(1933-1935)CCA>ACA	p.P645T	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.P645T|CNOT1_uc002enx.2_Missense_Mutation_p.P645T|CNOT1_uc002enz.1_Missense_Mutation_p.P74T	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	645					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AAAGTTTCTGGAGGAAGTTGA	0.408													1	0	2.32078e-09	1	2.5472e-09	15	115										T	58608559	G	T	58608559	3	4	68	1	0	0	0	0	1	0	0	0	3617	1174	41	3	5555	3	CNOT1	16	58608559	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	16082	58608559	31746194	780	21300	108	2								
CNOT1	23019	broad.mit.edu	37	chr16	58608568	58608568	+	Missense_Mutation	SNP	G	G	C													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaagtttctggaggaagttGagcacttttgggctggtctt							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:58608568G>C	uc002env.2	-	16	2217	c.1924C>G	c.(1924-1926)CAA>GAA	p.Q642E	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.Q642E|CNOT1_uc002enx.2_Missense_Mutation_p.Q642E|CNOT1_uc002enz.1_Missense_Mutation_p.Q71E	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	642					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GGAGGAAGTTGAGCACTTTTG	0.433													0	0	0	1	0	14	108										C	58608568	G	C	58608568	3	2	68	1	0	0	0	0	1	0	0	0	3617	1299	45	1	5564	1	CNOT1	16	58608568	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9	58608568	31746185	781	21301	108	2								
TRADD	8717	broad.mit.edu	37	chr16	67190499	67190499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acaggaccaccttgtccagcGaggactccacaaacaggtat	9	13	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:67190499G>A	uc002eri.1	-	2	145	c.65C>T	c.(64-66)TCG>TTG	p.S22L	TRADD_uc002erh.1_5'Flank|TRADD_uc010vjb.1_Missense_Mutation_p.S22L	NM_003789	NP_003780	Q15628	TRADD_HUMAN	TNFRSF1A-associated via death domain	22					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|tumor necrosis factor-mediated signaling pathway	cytoskeleton|cytosol|receptor complex	binding, bridging|death domain binding|identical protein binding|kinase binding|signal transducer activity			lung(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		CTTGTCCAGCGAGGACTCCAC	0.617											OREG0023872	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	22	136										A	67190499	G	A	67190499	3	1	68	1	0	0	0	0	1	0	0	0	16433	1059	37	1	889	1	TRADD	16	67190499	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8581931	67190499	23164254	782	21302										
HSF4	3299	broad.mit.edu	37	chr16	67201421	67201421	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttagccctcacagggccaGgggccccatcatctctgaca	9	17	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:67201421G>A	uc002erl.1	+	10	1738	c.773G>A	c.(772-774)AGG>AAG	p.R258K	HSF4_uc002erm.1_Missense_Mutation_p.G263R|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_Intron	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	258	Interactions with DUSP26, MAPK1 and MAPK2.				response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		CACAGGGCCAGGGGCCCCATC	0.607													0	0	0	1	0	38	98										A	67201421	G	A	67201421	3	1	68	1	0	0	0	0	1	0	0	0	7398	1000	35	2	817	2	HSF4	16	67201421	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10922	67201421	23153332	783	21303										
FHOD1	29109	broad.mit.edu	37	chr16	67265987	67265987	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aactcatcaaagttgagcagAgcagccttaatgacatgcac	8	10	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:67265987A>C	uc002esl.2	-	14	2269	c.2157T>G	c.(2155-2157)GCT>GCG	p.A719A	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Silent_p.A526A	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	719	Interaction with ROCK1.|FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGTTGAGCAGAGCAGCCTTAA	0.567													0	0	0	1	0	4	49										C	67265987	A	C	67265987	2	2	68	1	0	0	0	0	0	0	0	1	5882	291	11	5		5	FHOD1	16	67265987	Silent	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	64566	67265987	23088766	784	21304										
KCTD19	146212	broad.mit.edu	37	chr16	67327463	67327463	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcacctctctccttggtcctCtgcttgctccagtccttcag	6	17	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:67327463C>T	uc002esu.2	-	12	2253	c.2202G>A	c.(2200-2202)CAG>CAA	p.Q734Q	KCTD19_uc002est.2_Silent_p.Q506Q|KCTD19_uc010vjj.1_Silent_p.Q477Q	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	734						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCTTGGTCCTCTGCTTGCTCC	0.423													0	0	0	1	0	36	113										T	67327463	C	T	67327463	2	4	68	1	0	0	0	0	0	0	0	1	8106	912	32	1		1	KCTD19	16	67327463	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	61476	67327463	23027290	785	21305										
CTCF	10664	broad.mit.edu	37	chr16	67671650	67671650	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caattgagaacattatagttGaagtaaaaaaagagccagat	8	4	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:67671650G>T	uc002etl.2	+	12	2349	c.2059G>T	c.(2059-2061)GAA>TAA	p.E687*	CTCF_uc010cek.2_Nonsense_Mutation_p.E359*|CTCF_uc002etm.1_Nonsense_Mutation_p.E174*	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	687					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CATTATAGTTGAAGTAAAAAA	0.498													1	0	1.26484e-09	1	1.39432e-09	8	66										T	67671650	G	T	67671650	4	4	68	1	0	0	0	0	0	1	0	0	4000	1291	45	3	2097	3	CTCF	16	67671650	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	344187	67671650	22683103	786	21306										
HAS3	3038	broad.mit.edu	37	chr16	69143703	69143703	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gacgcctacatgctggacatCttccacgaggtgctgggcgg	14	12	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:69143703C>T	uc010cfh.2	+	2	629	c.405C>T	c.(403-405)ATC>ATT	p.I135I	HAS3_uc002ewk.2_Silent_p.I135I|HAS3_uc010vlk.1_Silent_p.I135I|HAS3_uc002ewl.2_Silent_p.I135I	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	135	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TGCTGGACATCTTCCACGAGG	0.652													0	0	0	1	0	22	48										T	69143703	C	T	69143703	2	4	68	1	0	0	0	0	0	0	0	1	6963	903	32	1		1	HAS3	16	69143703	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1472053	69143703	21211050	787	21307										
HAS3	3038	broad.mit.edu	37	chr16	69143910	69143910	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacacggccttcaaggccctCggcgattcggtggactacat	11	13	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:69143910C>G	uc010cfh.2	+	2	836	c.612C>G	c.(610-612)CTC>CTG	p.L204L	HAS3_uc002ewk.2_Silent_p.L204L|HAS3_uc010vlk.1_Silent_p.L204L|HAS3_uc002ewl.2_Silent_p.L204L	NM_005329	NP_005320	O00219	HAS3_HUMAN	hyaluronan synthase 3 isoform a	204	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		TCAAGGCCCTCGGCGATTCGG	0.602													0	0	0	1	0	16	27										G	69143910	C	G	69143910	2	3	68	1	0	0	0	0	0	0	0	1	6963	871	31	1		1	HAS3	16	69143910	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	207	69143910	21210843	788	21308										
VPS4A	27183	broad.mit.edu	37	chr16	69354143	69354143	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggtcccgaaatgaaaatgaGagtgaggccgcccggaggat	16	8	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:69354143G>C	uc002eww.2	+	7	848	c.720G>C	c.(718-720)GAG>GAC	p.E240D		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting factor 4A	240					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)				ATGAAAATGAGAGTGAGGCCG	0.582													0	0	0	1	0	9	33										C	69354143	G	C	69354143	3	2	68	1	0	0	0	0	1	0	0	0	17209	933	33	1	746	1	VPS4A	16	69354143	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	210233	69354143	21000610	789	21309										
DDX19B	11269	broad.mit.edu	37	chr16	70363869	70363869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaagagaccctggacaccatCaagcagtactatgtcctgtg	10	11	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:70363869C>T	uc002eyo.2	+	9	1050	c.921C>T	c.(919-921)ATC>ATT	p.I307I	DDX19B_uc010vly.1_Silent_p.I307I|DDX19A_uc002eys.2_Intron|DDX19B_uc010vlv.1_Silent_p.I281I|DDX19B_uc010vlw.1_Silent_p.I198I|DDX19B_uc002eyp.2_Silent_p.I276I|DDX19B_uc002eyq.2_Silent_p.I198I|DDX19B_uc002eyr.2_Silent_p.I156I|DDX19B_uc010vlx.1_Silent_p.I156I|uc002eyt.2_Intron	NM_007242	NP_009173	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	307	Helicase C-terminal.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			kidney(1)	1		Ovarian(137;0.0694)				TGGACACCATCAAGCAGTACT	0.527													0	0	0	1	0	29	162										T	70363869	C	T	70363869	2	4	68	1	0	0	0	0	0	0	0	1	4347	816	29	1		1	DDX19B	16	70363869	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1009726	70363869	19990884	790	21310										
HYDIN	54768	broad.mit.edu	37	chr16	70843817	70843817	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgtggctttcagatagagctCatattggtagtaacccaagt	10	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:70843817C>T	uc002ezr.2	-	85	14877	c.14749G>A	c.(14749-14751)GAG>AAG	p.E4917K	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4918										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGATAGAGCTCATATTGGTAG	0.468													0	0	0	1	0	131	352										T	70843817	C	T	70843817	3	4	68	1	0	0	0	0	1	0	0	0	7467	835	29	1	621	1	HYDIN	16	70843817	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	479948	70843817	19510936	791	21311										
HYDIN	54768	broad.mit.edu	37	chr16	70843871	70843871	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttagtcttccgaaggtttCtccagctttcaggggctgaa	11	9	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:70843871C>T	uc002ezr.2	-	85	14823	c.14695G>A	c.(14695-14697)GAA>AAA	p.E4899K	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4900										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCGAAGGTTTCTCCAGCTTTC	0.473													0	0	0	1	0	118	287										T	70843871	C	T	70843871	3	4	68	1	0	0	0	0	1	0	0	0	7467	922	32	1	675	1	HYDIN	16	70843871	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	54	70843871	19510882	792	21312										
PHLPP2	23035	broad.mit.edu	37	chr16	71748679	71748679	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctcctattcaaacaatttCtgctcccattgcgtttcata	3	12	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:71748679C>A	uc002fax.2	-	1	26	c.20G>T	c.(19-21)AGA>ATA	p.R7I	PHLPP2_uc010cgf.2_Missense_Mutation_p.R7I|PHLPP2_uc002fay.1_Missense_Mutation_p.R7I	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	7						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						CAAACAATTTCTGCTCCCATT	0.393													1	0	2.39556e-15	1	2.72666e-15	21	40										A	71748679	C	A	71748679	3	1	68	1	0	0	0	0	1	0	0	0	11855	913	32	3	4023	3	PHLPP2	16	71748679	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	904808	71748679	18606074	793	21313										
PMFBP1	83449	broad.mit.edu	37	chr16	72174473	72174473	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgaatgatcacccttgttCtcaggctcctgagagattta	8	9	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:72174473C>T	uc002fcc.3	-	6	817	c.645G>A	c.(643-645)GAG>GAA	p.E215E	PMFBP1_uc002fcd.2_Silent_p.E215E|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.E70E	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	215										ovary(2)	2		Ovarian(137;0.179)				CACCCTTGTTCTCAGGCTCCT	0.388													0	0	0	1	0	28	141										T	72174473	C	T	72174473	2	4	68	1	0	0	0	0	0	0	0	1	12134	912	32	1		1	PMFBP1	16	72174473	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	425794	72174473	18180280	794	21314										
KCNG4	93107	broad.mit.edu	37	chr16	84270993	84270993	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taaaggcccttgatggacggCgtctccatggggctggacag	15	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:84270993C>T	uc010voc.1	-	2	220	c.99G>A	c.(97-99)ACG>ACA	p.T33T	KCNG4_uc002fhu.1_Silent_p.T33T	NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	33	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						TGATGGACGGCGTCTCCATGG	0.627													0	0	0	1	0	11	54										T	84270993	C	T	84270993	2	4	68	1	0	0	0	0	0	0	0	1	8030	755	27	2		2	KCNG4	16	84270993	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	12096520	84270993	6083760	795	21315										
KIAA0182	23199	broad.mit.edu	37	chr16	85691040	85691040	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acagccctgctgatccagcgCaccaatgaggaggagaagtg	13	11	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:85691040C>A	uc002fix.2	+	8	1544	c.1470C>A	c.(1468-1470)CGC>CGA	p.R490R	KIAA0182_uc002fiw.2_Silent_p.R386R|KIAA0182_uc002fiy.2_Silent_p.R417R	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	490							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						TGATCCAGCGCACCAATGAGG	0.662													1	0	0.184627	1	0.184921	5	35										A	85691040	C	A	85691040	2	1	68	1	0	0	0	0	0	0	0	1	8159	697	25	4		4	KIAA0182	16	85691040	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1420047	85691040	4663713	796	21316										
ANKRD11	29123	broad.mit.edu	37	chr16	89346347	89346347	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagggctcaggctcgagctcTgcagggagccgggtggaggc	20	10	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:89346347T>C	uc002fmx.1	-	9	7064	c.6603A>G	c.(6601-6603)GCA>GCG	p.A2201A	ANKRD11_uc002fmy.1_Silent_p.A2201A|ANKRD11_uc002fnc.1_Silent_p.A2201A|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Silent_p.A2158A	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2201	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCTCGAGCTCTGCAGGGAGCC	0.687													0	0	0	1	0	4	19										C	89346347	T	C	89346347	2	2	68	1	0	0	0	0	0	0	0	1	639	1567	55	5		5	ANKRD11	16	89346347	Silent	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	3655307	89346347	1008406	797	21317										
ZNF276	92822	broad.mit.edu	37	chr16	89789204	89789204	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagtccttcctgcagagggtCaacgcctccccggctggtcg	12	15	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:89789204C>T	uc002fos.3	+	2	568	c.471C>T	c.(469-471)GTC>GTT	p.V157V	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Silent_p.V82V|ZNF276_uc002foq.3_Silent_p.V82V|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TGCAGAGGGTCAACGCCTCCC	0.597													0	0	0	1	0	16	92										T	89789204	C	T	89789204	2	4	68	1	0	0	0	0	0	0	0	1	17808	813	29	1		1	ZNF276	16	89789204	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	442857	89789204	565549	798	21318										
SPIRE2	84501	broad.mit.edu	37	chr16	89922055	89922055	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagaaggacgctcacgagctCatcctggactttatccgctc	9	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:89922055C>T	uc002foz.1	+	6	991	c.939C>T	c.(937-939)CTC>CTT	p.L313L	SPIRE2_uc010civ.1_Silent_p.L228L|SPIRE2_uc010ciw.1_Silent_p.L313L|SPIRE2_uc002fpa.1_Silent_p.L265L|SPIRE2_uc010cix.1_Silent_p.L180L	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	313					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CTCACGAGCTCATCCTGGACT	0.667													0	0	0	1	0	17	39										T	89922055	C	T	89922055	2	4	68	1	0	0	0	0	0	0	0	1	15071	813	29	1		1	SPIRE2	16	89922055	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	132851	89922055	432698	799	21319										
TUBB3	10381	broad.mit.edu	37	chr16	90001759	90001759	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcgatgccaagaacatgatGgccgcctgcgacccgcgcca	11	15	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:90001759G>A	uc002fph.1	+	4	965	c.900G>A	c.(898-900)ATG>ATA	p.M300I	TUBB3_uc002fpf.2_Missense_Mutation_p.M647I|TUBB3_uc010ciz.1_Missense_Mutation_p.M228I|TUBB3_uc002fpg.1_Missense_Mutation_p.M154I|TUBB3_uc002fpi.1_Missense_Mutation_p.M228I|TUBB3_uc002fpj.1_Missense_Mutation_p.M228I|TUBB3_uc010cjb.1_Missense_Mutation_p.M154I|TUBB3_uc002fpk.1_Missense_Mutation_p.M154I	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	300					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		AGAACATGATGGCCGCCTGCG	0.692													0	0	0	1	0	38	119										A	90001759	G	A	90001759	3	1	68	1	0	0	0	0	1	0	0	0	16754	1348	47	2	914	2	TUBB3	16	90001759	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	79704	90001759	352994	800	21320										
PRDM7	11105	broad.mit.edu	37	chr16	90142264	90142264	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctcaccatgggcttccgctCtgttctctctgtgtctcctt	7	15	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr16:90142264C>T	uc010cje.2	-	1	75	c.55G>A	c.(55-57)GAG>AAG	p.E19K	PRDM7_uc010cjf.2_5'UTR|PRDM7_uc010cjh.1_RNA	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	19						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGCTTCCGCTCTGTTCTCTCT	0.592													0	0	0	1	0	8	27										T	90142264	C	T	90142264	3	4	68	1	0	0	0	0	1	0	0	0	12461	922	32	1	1463	1	PRDM7	16	90142264	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	140505	90142264	212489	801	21321										
TUSC5	286753	broad.mit.edu	37	chr17	1183494	1183494	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacccttcaaggccatctccGaggggcacctggaggcccca	11	16	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:1183494G>C	uc002fsi.1	+	1	538	c.199G>C	c.(199-201)GAG>CAG	p.E67Q		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	67					response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGCCATCTCCGAGGGGCACCT	0.632													0	0	0	1	0	16	43										C	1183494	G	C	1183494	3	2	68	1	0	0	0	0	1	0	0	0	16776	1059	37	1	201	1	TUSC5	17	1183494	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		1183494	80011716	802	21322										
MYO1C	4641	broad.mit.edu	37	chr17	1374391	1374391	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctgccgccggacctccaggGcatcctctgtggcaaacagg	12	15	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:1374391G>A	uc002fsp.2	-	21	2406	c.2186C>T	c.(2185-2187)GCC>GTC	p.A729V	MYO1C_uc002fsn.2_Missense_Mutation_p.A710V|MYO1C_uc002fso.2_Missense_Mutation_p.A694V|MYO1C_uc010vqj.1_Missense_Mutation_p.A694V|MYO1C_uc010vqk.1_Missense_Mutation_p.A705V	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	729					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GACCTCCAGGGCATCCTCTGT	0.632													0	0	0	1	0	12	32										A	1374391	G	A	1374391	3	1	68	1	0	0	0	0	1	0	0	0	10070	1203	42	2	1053	2	MYO1C	17	1374391	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	190897	1374391	79820819	803	21323										
ALOX15	246	broad.mit.edu	37	chr17	4535233	4535233	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagtgatggacatctggagaGaagcctggtggaagttgggc	17	5	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:4535233G>C	uc002fyh.2	-	13	1774	c.1760C>G	c.(1759-1761)TCT>TGT	p.S587C	ALOX15_uc010vsd.1_Missense_Mutation_p.S548C|ALOX15_uc010vse.1_Missense_Mutation_p.S609C	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	587	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	CATCTGGAGAGAAGCCTGGTG	0.622													0	0	0	1	0	8	50										C	4535233	G	C	4535233	3	2	68	1	0	0	0	0	1	0	0	0	538	942	33	1	236	1	ALOX15	17	4535233	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3160842	4535233	76659977	804	21324										
NUP88	4927	broad.mit.edu	37	chr17	5289552	5289552	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtttacatgattgcggatatCattgatttgcttcaccattt	7	7	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:5289552C>T	uc002gbo.1	-	17	2226	c.2200G>A	c.(2200-2202)GAT>AAT	p.D734N	NUP88_uc002gbn.2_5'Flank|NUP88_uc010vsx.1_Missense_Mutation_p.D750N	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	734					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						TTGCGGATATCATTGATTTGC	0.363													0	0	0	1	0	18	110										T	5289552	C	T	5289552	3	4	68	1	0	0	0	0	1	0	0	0	10771	826	29	1	29	1	NUP88	17	5289552	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	754319	5289552	75905658	805	21325										
DHX33	56919	broad.mit.edu	37	chr17	5347829	5347829	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggatgatgcgattggcattGacatctgtttcgggagaaag	15	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:5347829G>C	uc002gca.2	-	12	1822	c.1820C>G	c.(1819-1821)TCA>TGA	p.S607*	DHX33_uc002gbz.2_Nonsense_Mutation_p.S378*|DHX33_uc002gcb.2_Nonsense_Mutation_p.S434*|DHX33_uc010clf.2_Nonsense_Mutation_p.S383*	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	607						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GATTGGCATTGACATCTGTTT	0.597													0	0	0	1	0	7	27										C	5347829	G	C	5347829	4	2	68	1	0	0	0	0	0	1	0	0	4506	1294	45	1	307	1	DHX33	17	5347829	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	58277	5347829	75847381	806	21326										
ZBTB4	57659	broad.mit.edu	37	chr17	7365511	7365511	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgtaagggtaggcggcaagGagctgggggccatagacgag	19	6	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:7365511G>T	uc002ghc.3	-	4	3040	c.2790C>A	c.(2788-2790)CTC>CTA	p.L930L	ZBTB4_uc002ghd.3_Silent_p.L930L	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	930					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		AGGCGGCAAGGAGCTGGGGGC	0.627													1	0	3.73148e-12	1	4.19043e-12	30	128										T	7365511	G	T	7365511	2	4	68	1	0	0	0	0	0	0	0	1	17538	1161	41	3		3	ZBTB4	17	7365511	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2017682	7365511	73829699	807	21327										
TNFSF12	8742	broad.mit.edu	37	chr17	7460637	7460637	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcaaggctgcccccttcctCacctacttcggactcttcca	5	19	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:7460637C>A	uc002ghg.2	+	7	816	c.720C>A	c.(718-720)CTC>CTA	p.L240L	TNFSF12_uc002ghh.2_RNA|TNFSF12-TNFSF13_uc002ghi.1_Intron|TNFSF13_uc002ghj.2_5'Flank|TNFSF13_uc002ghk.2_5'Flank|TNFSF13_uc002ghl.2_5'Flank|TNFSF13_uc010cmk.2_5'Flank|TNFSF13_uc010vua.1_5'Flank	NM_003809	NP_003800	O43508	TNF12_HUMAN	tumor necrosis factor (ligand) superfamily,	240	Extracellular (Potential).				angiogenesis|apoptosis|cell differentiation|endothelial cell migration|immune response|induction of apoptosis|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|signal transduction	extracellular space|integral to plasma membrane|perinuclear region of cytoplasm	cytokine activity|tumor necrosis factor receptor binding				0		Prostate(122;0.157)				CCCCCTTCCTCACCTACTTCG	0.692													1	0	3.09899e-07	1	3.31189e-07	9	30										A	7460637	C	A	7460637	2	1	68	1	0	0	0	0	0	0	0	1	16300	813	29	3		3	TNFSF12	17	7460637	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	95126	7460637	73734573	808	21328										
TP53	7157	broad.mit.edu	37	chr17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acaggcacaaacacgcacctCaaagctgttccgtcccagta	7	15	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	17	17										T	7577127	C	T	7577127	3	4	68	1	0	0	0	0	1	0	0	0	16378	835	29	1	475	1	TP53	17	7577127	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	116490	7577127	73618083	809	21329										
ZNF624	57547	broad.mit.edu	37	chr17	16552976	16552976	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggaatcccaacttaccaggCgtccaactgagaaaaacaca	8	12	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:16552976C>G	uc010cpi.1	-	2	166	c.83G>C	c.(82-84)CGC>CCC	p.R28P		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	28					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		ACTTACCAGGCGTCCAACTGA	0.468													0	0	0	1	0	4	28										G	16552976	C	G	16552976	3	3	68	1	0	0	0	0	1	0	0	0	18045	768	27	4	2534	4	ZNF624	17	16552976	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	8975849	16552976	64642234	810	21330										
MYO15A	51168	broad.mit.edu	37	chr17	18025324	18025324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccactggctgcgtgtgaccaGaccagggccacatggccacc	12	16	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:18025324G>C	uc010vxh.1	+	2	3548	c.3210G>C	c.(3208-3210)CAG>CAC	p.Q1070H		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1070	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CGTGTGACCAGACCAGGGCCA	0.647													0	0	0	1	0	22	75										C	18025324	G	C	18025324	3	2	68	1	0	0	0	0	1	0	0	0	10063	933	33	1	3212	1	MYO15A	17	18025324	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1472348	18025324	63169886	811	21331										
FBXW10	10517	broad.mit.edu	37	chr17	18668067	18668067	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcctgcagatactgggatctGaaaagtggggtttgcacacg	13	8	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:18668067G>T	uc002guk.2	+	8	1678	c.1446G>T	c.(1444-1446)CTG>CTT	p.L482L	FBXW10_uc002guj.2_Silent_p.L482L|FBXW10_uc002gul.2_Silent_p.L511L|FBXW10_uc010cqh.1_Silent_p.L482L	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	482	WD 3.									ovary(1)	1						ACTGGGATCTGAAAAGTGGGG	0.483													1	0	2.23348e-06	1	2.36288e-06	15	40										T	18668067	G	T	18668067	2	4	68	1	0	0	0	0	0	0	0	1	5763	1277	45	3		3	FBXW10	17	18668067	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	642743	18668067	62527143	812	21332										
CYTSB	92521	broad.mit.edu	37	chr17	20130924	20130924	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acaataatcaactcatcagtGagctagaaagtaagtggggt	10	6	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:20130924G>C	uc002gwq.2	+	5	2207	c.2062G>C	c.(2062-2064)GAG>CAG	p.E688Q	CYTSB_uc010cqx.2_Missense_Mutation_p.E688Q|CYTSB_uc002gwr.2_Missense_Mutation_p.E688Q|CYTSB_uc002gws.2_Missense_Mutation_p.E688Q|CYTSB_uc002gwv.2_Missense_Mutation_p.E607Q|CYTSB_uc010vzf.1_Missense_Mutation_p.E28Q|CYTSB_uc002gww.2_Missense_Mutation_p.E464Q|CYTSB_uc002gwt.2_Missense_Mutation_p.E607Q|CYTSB_uc002gwu.2_Missense_Mutation_p.E607Q	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	688	Potential.					nucleus					0						ACTCATCAGTGAGCTAGAAAG	0.254													0	0	0	1	0	11	41										C	20130924	G	C	20130924	3	2	68	1	0	0	0	0	1	0	0	0	4210	1291	45	1	2120	1	CYTSB	17	20130924	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1462857	20130924	61064286	813	21333										
SLC13A2	9058	broad.mit.edu	37	chr17	26818799	26818799	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcgcctcctggttcagcttCgccttccccaccatggtcat	7	17	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:26818799C>T	uc002hbh.2	+	6	874	c.807C>T	c.(805-807)TTC>TTT	p.F269F	SLC13A2_uc010wal.1_Silent_p.F226F|SLC13A2_uc010wam.1_Silent_p.F225F|SLC13A2_uc010wan.1_Silent_p.F318F|SLC13A2_uc010wao.1_Silent_p.F226F|SLC13A2_uc002hbi.2_Silent_p.F198F	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	269						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GGTTCAGCTTCGCCTTCCCCA	0.582													0	0	0	1	0	9	77										T	26818799	C	T	26818799	2	4	68	1	0	0	0	0	0	0	0	1	14392	883	31	1		1	SLC13A2	17	26818799	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6687875	26818799	54376411	814	21334										
PIGS	94005	broad.mit.edu	37	chr17	26890912	26890912	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccttctggaaacggcatttGattttcattttgtctgggag	11	7	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:26890912G>C	uc002hbo.2	-	4	673	c.300C>G	c.(298-300)ATC>ATG	p.I100M	PIGS_uc002hbn.2_Missense_Mutation_p.I92M|PIGS_uc010wap.1_Missense_Mutation_p.I39M	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	100	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					AACGGCATTTGATTTTCATTT	0.522													0	0	0	1	0	17	110										C	26890912	G	C	26890912	3	2	68	1	0	0	0	0	1	0	0	0	11898	1280	45	1	1403	1	PIGS	17	26890912	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	72113	26890912	54304298	815	21335										
KIAA0100	9703	broad.mit.edu	37	chr17	26951382	26951382	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacaaacctatctgtctcttCaattagcttctgcaacatgt	4	11	4	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:26951382C>T	uc002hbu.2	-	25	4720	c.4621G>A	c.(4621-4623)GAA>AAA	p.E1541K	KIAA0100_uc002hbt.2_5'Flank	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1541						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TCTGTCTCTTCAATTAGCTTC	0.463													0	0	0	1	0	14	59										T	26951382	C	T	26951382	3	4	68	1	0	0	0	0	1	0	0	0	8154	835	29	1	2146	1	KIAA0100	17	26951382	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	60470	26951382	54243828	816	21336										
TLCD1	116238	broad.mit.edu	37	chr17	27051561	27051561	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aacttgtctttgtgttgcttCttggggacatgctcagggca	12	8	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:27051561C>A	uc002hco.2	-	4	826	c.711G>T	c.(709-711)AAG>AAT	p.K237N	TLCD1_uc010waw.1_Missense_Mutation_p.K190N	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	237						integral to membrane					0	Lung NSC(42;0.00431)					TGTGTTGCTTCTTGGGGACAT	0.522													1	0	3.90053e-15	1	4.43562e-15	30	202										A	27051561	C	A	27051561	3	1	68	1	0	0	0	0	1	0	0	0	15934	912	32	3	36	3	TLCD1	17	27051561	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	100179	27051561	54143649	817	21337										
TLCD1	116238	broad.mit.edu	37	chr17	27052547	27052547	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agaaagtgaccacgccgtctCaatctccactaacatgtcag	7	13	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:27052547C>G	uc002hco.2	-	2	344	c.229G>C	c.(229-231)GAG>CAG	p.E77Q	TLCD1_uc010waw.1_Missense_Mutation_p.E30Q	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	77	TLC.|Helical; (Potential).					integral to membrane					0	Lung NSC(42;0.00431)					CACGCCGTCTCAATCTCCACT	0.542													0	0	0	1	0	24	110										G	27052547	C	G	27052547	3	3	68	1	0	0	0	0	1	0	0	0	15934	835	29	1	526	1	TLCD1	17	27052547	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	986	27052547	54142663	818	21338										
PIPOX	51268	broad.mit.edu	37	chr17	27382234	27382234	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtcattgagagctgcatgTacacggtaaggggtctgggc	15	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:27382234T>C	uc002hdr.1	+	6	1287	c.961T>C	c.(961-963)TAC>CAC	p.Y321H		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	321					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	GAGCTGCATGTACACGGTAAG	0.567													0	0	0	1	0	30	133										C	27382234	T	C	27382234	3	2	68	1	0	0	0	0	1	0	0	0	11943	1638	57	5	983	5	PIPOX	17	27382234	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	329687	27382234	53812976	819	21339										
CORO6	84940	broad.mit.edu	37	chr17	27943318	27943318	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttgcggggcacagtcatgatGataggttcacactttctttc	10	9	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:27943318G>A	uc002hel.2	-	8	1043	c.1041C>T	c.(1039-1041)ATC>ATT	p.I347I	CORO6_uc002hem.2_Silent_p.I113I|CORO6_uc002hen.2_Silent_p.I113I	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	347					actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CAGTCATGATGATAGGTTCAC	0.572													0	0	0	1	0	3	17										A	27943318	G	A	27943318	2	1	68	1	0	0	0	0	0	0	0	1	3758	1280	45	1		1	CORO6	17	27943318	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	561084	27943318	53251892	820	21340										
CCL13	6357	broad.mit.edu	37	chr17	32685093	32685093	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtgctgacccaaaggagaaGtgggtccagaattatatgaa	12	6	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:32685093G>C	uc002hic.2	+	3	315	c.240G>C	c.(238-240)AAG>AAC	p.K80N		NM_005408	NP_005399	Q99616	CCL13_HUMAN	small inducible cytokine A13 precursor	80					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity				0		Ovarian(249;0.0443)|Breast(31;0.151)				CAAAGGAGAAGTGGGTCCAGA	0.493													0	0	0	1	0	19	33										C	32685093	G	C	32685093	3	2	68	1	0	0	0	0	1	0	0	0	2884	1020	36	4	250	4	CCL13	17	32685093	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4741775	32685093	48510117	821	21341										
TMEM132E	124842	broad.mit.edu	37	chr17	32964869	32964869	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcagccgctgcgggtgcaagGagagctgtcgccgccagcag	17	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:32964869G>T	uc002hif.2	+	10	2901	c.2573G>T	c.(2572-2574)GGA>GTA	p.G858V		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	858	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CGGGTGCAAGGAGAGCTGTCG	0.697													1	0	9.04072e-19	1	1.03463e-18	37	30										T	32964869	G	T	32964869	3	4	68	1	0	0	0	0	1	0	0	0	16045	1174	41	3	2611	3	TMEM132E	17	32964869	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	279776	32964869	48230341	822	21342										
UNC45B	146862	broad.mit.edu	37	chr17	33501356	33501356	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgaaagcagatagtgccatCctcactgaccagaccaagga	10	11	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:33501356C>G	uc002hja.2	+	14	2029	c.1932C>G	c.(1930-1932)ATC>ATG	p.I644M	UNC45B_uc002hjb.2_Missense_Mutation_p.I642M|UNC45B_uc002hjc.2_Missense_Mutation_p.I642M|UNC45B_uc010cto.2_Missense_Mutation_p.I563M	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	644					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				ATAGTGCCATCCTCACTGACC	0.597													0	0	0	1	0	12	82										G	33501356	C	G	33501356	3	3	68	1	0	0	0	0	1	0	0	0	16986	845	30	1	1982	1	UNC45B	17	33501356	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	536487	33501356	47693854	823	21343										
AP2B1	163	broad.mit.edu	37	chr17	33953812	33953812	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctttgctgtctggggagccaGaagtgcagtatgtcgccctg	14	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:33953812G>A	uc002hjr.2	+	7	1078	c.889G>A	c.(889-891)GAA>AAA	p.E297K	AP2B1_uc002hjq.2_Missense_Mutation_p.E297K|AP2B1_uc010wci.1_Missense_Mutation_p.E259K|AP2B1_uc002hjs.2_Missense_Mutation_p.E240K|AP2B1_uc002hjt.2_Missense_Mutation_p.E297K|AP2B1_uc010ctv.2_Missense_Mutation_p.E297K|AP2B1_uc010wcj.1_Missense_Mutation_p.E34K	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	297					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TGGGGAGCCAGAAGTGCAGTA	0.408													0	0	0	1	0	38	226										A	33953812	G	A	33953812	3	1	68	1	0	0	0	0	1	0	0	0	741	943	33	1	911	1	AP2B1	17	33953812	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	452456	33953812	47241398	824	21344										
CCL16	6360	broad.mit.edu	37	chr17	34308454	34308454	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agggcagcctcggagaccttCatcctctcagcgaggcagta	12	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:34308454C>T	uc002hkl.2	-	1	70	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CCL16_uc002hkm.2_RNA	NM_004590	NP_004581	O15467	CCL16_HUMAN	small inducible cytokine A16 precursor	1					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CGGAGACCTTCATCCTCTCAG	0.547													0	0	0	1	0	3	13										T	34308454	C	T	34308454	3	4	68	1	0	0	0	0	1	0	0	0	2887	826	29	1	371	1	CCL16	17	34308454	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	354642	34308454	46886756	825	21345										
GGNBP2	79893	broad.mit.edu	37	chr17	34923593	34923593	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttgtcttttagaaacactaGaaacatatctgcgaaaacac	6	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:34923593G>C	uc002hnb.2	+	6	868	c.619G>C	c.(619-621)GAA>CAA	p.E207Q	GGNBP2_uc002hna.2_Missense_Mutation_p.E207Q	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	207					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGAAACACTAGAAACATATCT	0.418													0	0	0	1	0	16	61										C	34923593	G	C	34923593	3	2	68	1	0	0	0	0	1	0	0	0	6359	943	33	1	637	1	GGNBP2	17	34923593	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	615139	34923593	46271617	826	21346										
LHX1	3975	broad.mit.edu	37	chr17	35298106	35298106	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagacgctgaaggccgccttCgctgctacacccaagcccac	10	17	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:35298106C>T	uc002hnh.1	+	3	1593	c.597C>T	c.(595-597)TTC>TTT	p.F199F	LHX1_uc010cux.1_Silent_p.F107F	NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	199	Homeobox.				cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				AGGCCGCCTTCGCTGCTACAC	0.677													0	0	0	1	0	7	17										T	35298106	C	T	35298106	2	4	68	1	0	0	0	0	0	0	0	1	8770	883	31	1		1	LHX1	17	35298106	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	374513	35298106	45897104	827	21347										
ACACA	31	broad.mit.edu	37	chr17	35634815	35634815	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgggatccttttagcaatatCaagaattaattccacatttg	6	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:35634815C>T	uc002hnm.2	-	6	774	c.583G>A	c.(583-585)GAT>AAT	p.D195N	ACACA_uc002hnk.2_Missense_Mutation_p.D117N|ACACA_uc002hnl.2_Missense_Mutation_p.D137N|ACACA_uc002hnn.2_Missense_Mutation_p.D195N|ACACA_uc002hno.2_Missense_Mutation_p.D232N|ACACA_uc010cuz.2_Missense_Mutation_p.D195N|ACACA_uc002hnq.2_Missense_Mutation_p.D117N	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	195	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTAGCAATATCAAGAATTAAT	0.383													0	0	0	1	0	7	48										T	35634815	C	T	35634815	3	4	68	1	0	0	0	0	1	0	0	0	106	826	29	1	6661	1	ACACA	17	35634815	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	336709	35634815	45560395	828	21348										
TADA2A	6871	broad.mit.edu	37	chr17	35804846	35804846	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgagagacattgattttgttGaagatgactcggacatttta	10	4	0	6			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:35804846G>A	uc002hnt.2	+	8	737	c.580G>A	c.(580-582)GAA>AAA	p.E194K	TADA2A_uc002hnu.1_Missense_Mutation_p.E194K|TADA2A_uc002hnv.2_Missense_Mutation_p.E194K|TADA2A_uc010wdd.1_Missense_Mutation_p.E194K|TADA2A_uc002hnw.2_Missense_Mutation_p.E93K|TADA2A_uc010cvb.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	194					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TGATTTTGTTGAAGATGACTC	0.269													0	0	0	1	0	38	218										A	35804846	G	A	35804846	3	1	68	1	0	0	0	0	1	0	0	0	15507	1291	45	1	606	1	TADA2A	17	35804846	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	170031	35804846	45390364	829	21349										
GPR179	440435	broad.mit.edu	37	chr17	36483085	36483085	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctctgctttcttggcagaggGagcctctaccacttcccaca	8	15	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:36483085G>A	uc002hpz.2	-	11	6388	c.6367C>T	c.(6367-6369)CCC>TCC	p.P2123S		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	2123	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTGGCAGAGGGAGCCTCTACC	0.572													0	0	0	1	0	21	108										A	36483085	G	A	36483085	3	1	68	1	0	0	0	0	1	0	0	0	6674	1174	41	1	740	1	GPR179	17	36483085	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	678239	36483085	44712125	830	21350										
CACNB1	782	broad.mit.edu	37	chr17	37347815	37347815	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagagatacatcagagtctGatggacggctggtgtaggac	14	8	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:37347815G>C	uc002hrm.1	-	3	356	c.203C>G	c.(202-204)TCA>TGA	p.S68*	CACNB1_uc002hrl.1_Translation_Start_Site|CACNB1_uc002hrn.2_Nonsense_Mutation_p.S68*|CACNB1_uc002hro.2_Nonsense_Mutation_p.S68*|CACNB1_uc002hrp.1_Nonsense_Mutation_p.S68*|CACNB1_uc010web.1_Nonsense_Mutation_p.S21*	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	68					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	ATCAGAGTCTGATGGACGGCT	0.587													0	0	0	1	0	23	38										C	37347815	G	C	37347815	4	2	68	1	0	0	0	0	0	1	0	0	2552	1294	45	1	1905	1	CACNB1	17	37347815	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	864730	37347815	43847395	831	21351										
TTC25	83538	broad.mit.edu	37	chr17	40117264	40117264	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaattaggcacaagatcaggAgaaacaggcaggaagctact	12	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:40117264A>G	uc002hyj.3	+	11	1871	c.1782A>G	c.(1780-1782)GGA>GGG	p.G594G	TTC25_uc010cxt.2_RNA|CNP_uc002hyk.1_5'Flank|CNP_uc002hyl.1_5'Flank|CNP_uc010wfz.1_5'Flank|CNP_uc002hym.1_5'Flank|CNP_uc010wga.1_5'Flank	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	594						cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				CAAGATCAGGAGAAACAGGCA	0.498													0	0	0	1	0	7	24										G	40117264	A	G	40117264	2	3	68	1	0	0	0	0	0	0	0	1	16690	291	11	5		5	TTC25	17	40117264	Silent	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	2769449	40117264	41077946	832	21352										
TUBG2	27175	broad.mit.edu	37	chr17	40818472	40818472	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccaccgggtcagcgggctCatgatggccaaccacaccag	12	16	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:40818472C>G	uc010wgr.1	+	10	1384	c.1128C>G	c.(1126-1128)CTC>CTG	p.L376L	TUBG2_uc002iaq.2_Silent_p.L218L|TUBG2_uc002iar.2_Silent_p.L223L|TUBG2_uc002ias.2_Silent_p.L218L|TUBG2_uc002iap.2_Silent_p.L223L	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	376					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TCAGCGGGCTCATGATGGCCA	0.587													0	0	0	1	0	14	121										G	40818472	C	G	40818472	2	3	68	1	0	0	0	0	0	0	0	1	16762	813	29	1		1	TUBG2	17	40818472	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	701208	40818472	40376738	833	21353										
NBR1	4077	broad.mit.edu	37	chr17	41341649	41341649	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acggttgagaagcttgaacaGaaattacatgaaaagcttgt	10	5	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:41341649G>A	uc010czd.2	+	8	665	c.525G>A	c.(523-525)CAG>CAA	p.Q175Q	NBR1_uc010diz.2_Silent_p.Q175Q|NBR1_uc010whu.1_Silent_p.Q175Q|NBR1_uc010whv.1_Silent_p.Q175Q|NBR1_uc010whw.1_Silent_p.Q154Q|NBR1_uc010whx.1_5'Flank	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	175					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		AGCTTGAACAGAAATTACATG	0.393													0	0	0	1	0	19	116										A	41341649	G	A	41341649	2	1	68	1	0	0	0	0	0	0	0	1	10200	933	33	1		1	NBR1	17	41341649	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	523177	41341649	39853561	834	21354										
C17orf53	78995	broad.mit.edu	37	chr17	42239247	42239247	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccctctctgtagatgacctgGatggactcctgagtgagctt	11	11	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:42239247G>C	uc002ifi.1	+	10	2076	c.1891G>C	c.(1891-1893)GAT>CAT	p.D631H	C17orf53_uc010czq.1_Missense_Mutation_p.D630H|C17orf53_uc002ifj.1_Missense_Mutation_p.W518C|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	631											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AGATGACCTGGATGGACTCCT	0.547													0	0	0	1	0	18	98										C	42239247	G	C	42239247	3	2	68	1	0	0	0	0	1	0	0	0	1862	1174	41	1	1929	1	C17orf53	17	42239247	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	897598	42239247	38955963	835	21355										
GFAP	2670	broad.mit.edu	37	chr17	42992744	42992744	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggggcattcgagccagggaGaggcgggtgccaggacccag	20	10	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:42992744G>C	uc002ihq.2	-	1	171	c.111C>G	c.(109-111)CTC>CTG	p.L37L	GFAP_uc002ihr.2_Silent_p.L37L|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	37	Head.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				GAGCCAGGGAGAGGCGGGTGC	0.692													0	0	0	1	0	11	21										C	42992744	G	C	42992744	2	2	68	1	0	0	0	0	0	0	0	1	6337	929	33	1		1	GFAP	17	42992744	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	753497	42992744	38202466	836	21356										
MAP3K14	9020	broad.mit.edu	37	chr17	43345029	43345029	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcccttggcgaaagctctctCggctgggcatggagggtctg	16	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:43345029C>T	uc002iiw.1	-	13	2179	c.2070G>A	c.(2068-2070)CCG>CCA	p.P690P	LOC100133991_uc010dah.2_Intron|LOC100133991_uc002iit.3_Intron|LOC100133991_uc010dai.2_Intron|MAP3K14_uc002iiu.1_Silent_p.P220P|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Silent_p.P274P	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	690					cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						AAAGCTCTCTCGGCTGGGCAT	0.607													0	0	0	1	0	13	140										T	43345029	C	T	43345029	2	4	68	1	0	0	0	0	0	0	0	1	9248	871	31	1		1	MAP3K14	17	43345029	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	352285	43345029	37850181	837	21357										
MAP3K14	9020	broad.mit.edu	37	chr17	43348526	43348526	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagacatccaccttggcgtCgcagctcctgcccagcacca	8	19	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:43348526C>T	uc002iiw.1	-	11	1829	c.1720G>A	c.(1720-1722)GAC>AAC	p.D574N	MAP3K14_uc002iiu.1_Missense_Mutation_p.D104N|MAP3K14_uc010daj.1_RNA|MAP3K14_uc002iiv.1_Missense_Mutation_p.D158N	NM_003954	NP_003945	Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase	574	Interaction with ZFP91.|Protein kinase.				cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			central_nervous_system(3)|breast(2)|lung(1)|ovary(1)|stomach(1)	8						ACCTTGGCGTCGCAGCTCCTG	0.597											OREG0024479	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	6	37										T	43348526	C	T	43348526	3	4	68	1	0	0	0	0	1	0	0	0	9248	884	31	1	1151	1	MAP3K14	17	43348526	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3497	43348526	37846684	838	21358										
PRR15L	79170	broad.mit.edu	37	chr17	46030598	46030598	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caccaaccaatttcagtcgtCatggcgctccctaagccaag	7	15	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:46030598C>T	uc002imp.2	-	2	120	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_024320	NP_077296	Q9BU68	PR15L_HUMAN	ATPase family, AAA domain containing 4	1										ovary(1)	1						TTTCAGTCGTCATGGCGCTCC	0.547													0	0	0	1	0	61	79										T	46030598	C	T	46030598	3	4	68	1	0	0	0	0	1	0	0	0	12588	826	29	1	312	1	PRR15L	17	46030598	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2682072	46030598	35164612	839	21359										
ATP5G1	516	broad.mit.edu	37	chr17	46973041	46973041	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccgtctctcaagcagcagctCttctcctatgccattcttgg	7	15	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:46973041C>G	uc002iog.2	+	5	455	c.321C>G	c.(319-321)CTC>CTG	p.L107L	ATP5G1_uc002ioh.2_Silent_p.L107L	NM_005175	NP_005166	P05496	AT5G1_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	107					ATP hydrolysis coupled proton transport|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding				0						AGCAGCAGCTCTTCTCCTATG	0.577													0	0	0	1	0	111	131										G	46973041	C	G	46973041	2	3	68	1	0	0	0	0	0	0	0	1	1153	900	32	1		1	ATP5G1	17	46973041	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	942443	46973041	34222169	840	21360										
NGFR	4804	broad.mit.edu	37	chr17	47583714	47583714	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agccgtgcaagccgtgcaccGagtgcgtggggctccagagc	16	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:47583714G>C	uc002ioz.3	+	3	387	c.262G>C	c.(262-264)GAG>CAG	p.E88Q		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	88	Extracellular (Potential).|TNFR-Cys 2.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GCCGTGCACCGAGTGCGTGGG	0.672													0	0	0	1	0	7	46										C	47583714	G	C	47583714	3	2	68	1	0	0	0	0	1	0	0	0	10396	1059	37	1	272	1	NGFR	17	47583714	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	610673	47583714	33611496	841	21361										
ACSF2	80221	broad.mit.edu	37	chr17	48540834	48540834	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcaggcacaatgatgtgtCtgatgtacggtgccaccctc	12	11	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:48540834C>G	uc002iqu.2	+	8	1071	c.967C>G	c.(967-969)CTG>GTG	p.L323V	ACSF2_uc010wml.1_Missense_Mutation_p.L280V|ACSF2_uc010wmm.1_Missense_Mutation_p.L348V|ACSF2_uc010wmn.1_Missense_Mutation_p.L310V|ACSF2_uc010wmo.1_Missense_Mutation_p.L163V	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	323					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AATGATGTGTCTGATGTACGG	0.587													0	0	0	1	0	30	40										G	48540834	C	G	48540834	3	3	68	1	0	0	0	0	1	0	0	0	175	912	32	1	997	1	ACSF2	17	48540834	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	957120	48540834	32654376	842	21362										
MYCBPAP	84073	broad.mit.edu	37	chr17	48601143	48601143	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggatgagaggaaagtactgGaggtaagggacccaggacca	16	6	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:48601143G>A	uc010wmr.1	+	12	1924	c.1762G>A	c.(1762-1764)GAG>AAG	p.E588K	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	551					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			GAAAGTACTGGAGGTAAGGGA	0.527													0	0	0	1	0	8	36										A	48601143	G	A	48601143	3	1	68	1	0	0	0	0	1	0	0	0	10019	1175	41	1	1808	1	MYCBPAP	17	48601143	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	60309	48601143	32594067	843	21363										
EPN3	55040	broad.mit.edu	37	chr17	48619216	48619216	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gttctgcaggtctcagcgctCcgtcccccaccaacccgttc	8	19	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:48619216C>T	uc002ira.3	+	10	2032	c.1597C>T	c.(1597-1599)CCG>TCG	p.P533S	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.P561S|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.P506S	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	533	3 X 3 AA repeats of N-P-F.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			TCTCAGCGCTCCGTCCCCCAC	0.692													0	0	0	1	0	8	34										T	48619216	C	T	48619216	3	4	68	1	0	0	0	0	1	0	0	0	5187	855	30	1	1631	1	EPN3	17	48619216	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	18073	48619216	32575994	844	21364										
ABCC3	8714	broad.mit.edu	37	chr17	48750880	48750880	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcctgccccagacagacttCatcattgtgctagctgatgg	9	12	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:48750880C>T	uc002isl.2	+	19	2540	c.2460C>T	c.(2458-2460)TTC>TTT	p.F820F		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	820	ABC transporter 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AGACAGACTTCATCATTGTGC	0.607													0	0	0	1	0	8	79										T	48750880	C	T	48750880	2	4	68	1	0	0	0	0	0	0	0	1	54	825	29	1		1	ABCC3	17	48750880	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	131664	48750880	32444330	845	21365										
MBTD1	54799	broad.mit.edu	37	chr17	49281254	49281254	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtccagaccagagtcattttCaaatccttcatatcttaaaa	4	10	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:49281254C>G	uc002itr.3	-	8	981	c.637G>C	c.(637-639)GAA>CAA	p.E213Q	MBTD1_uc002itp.3_Missense_Mutation_p.E49Q|MBTD1_uc002itq.3_Missense_Mutation_p.E213Q	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	213	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			GAGTCATTTTCAAATCCTTCA	0.368													0	0	0	1	0	106	140										G	49281254	C	G	49281254	3	3	68	1	0	0	0	0	1	0	0	0	9360	835	29	1	1289	1	MBTD1	17	49281254	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	530374	49281254	31913956	846	21366										
STXBP4	252983	broad.mit.edu	37	chr17	53218719	53218719	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacagcagatggaatcaagtActtcatcaagtaagtacaag	8	8	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:53218719A>G	uc002iuf.1	+	17	1745	c.1538A>G	c.(1537-1539)TAC>TGC	p.Y513C	STXBP4_uc010dcd.1_Missense_Mutation_p.Y491C	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	513	WW.					cytoplasm	calcium ion binding			ovary(1)	1						GGAATCAAGTACTTCATCAAG	0.358													0	0	0	1	0	12	70										G	53218719	A	G	53218719	3	3	68	1	0	0	0	0	1	0	0	0	15354	391	14	5	1596	5	STXBP4	17	53218719	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	3937465	53218719	27976491	847	21367										
EPX	8288	broad.mit.edu	37	chr17	56270423	56270423	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccctggggcagtggagacctCggtcctgcgagactgcatag	15	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:56270423C>T	uc002ivq.2	+	2	187	c.101C>T	c.(100-102)TCG>TTG	p.S34L		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	34					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						GTGGAGACCTCGGTCCTGCGA	0.597													0	0	0	1	0	66	148										T	56270423	C	T	56270423	3	4	68	1	0	0	0	0	1	0	0	0	5200	893	31	1	107	1	EPX	17	56270423	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3051704	56270423	24924787	848	21368										
SKA2	348235	broad.mit.edu	37	chr17	57189697	57189697	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttttctcttctttagtcaGtggtgacagctagaaaataa	8	6	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:57189697G>T	uc002ixd.2	-	4	583	c.307C>A	c.(307-309)CTG>ATG	p.L103M	uc002ixb.2_Intron|SKA2_uc002ixc.2_RNA|SKA2_uc010dde.1_Missense_Mutation_p.H75Q|SKA2_uc002ixe.2_RNA	NM_182620	NP_872426	Q8WVK7	SKA2_HUMAN	spindle and KT associated 2 isoform 1	103					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding				0						TCTTTAGTCAGTGGTGACAGC	0.323													1	0	1.42536e-11	1	1.59215e-11	27	48										T	57189697	G	T	57189697	3	4	68	1	0	0	0	0	1	0	0	0	14353	1020	36	4	62	4	SKA2	17	57189697	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	919274	57189697	24005513	849	21369										
USP32	84669	broad.mit.edu	37	chr17	58288742	58288742	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccagaaagattacctgttGagttcataaagatgtctccc	7	10	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:58288742G>C	uc002iyo.1	-	20	2599	c.2313C>G	c.(2311-2313)CTC>CTG	p.L771L	USP32_uc002iyn.1_Silent_p.L441L	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	771					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ATTACCTGTTGAGTTCATAAA	0.408													0	0	0	1	0	20	313										C	58288742	G	C	58288742	2	2	68	1	0	0	0	0	0	0	0	1	17060	1277	45	1		1	USP32	17	58288742	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1099045	58288742	22906468	850	21370										
TBX2	6909	broad.mit.edu	37	chr17	59479190	59479190	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcgggcaaggccgaccctGagatgcccaaacgcatgtac	13	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:59479190G>A	uc010wox.1	+	2	822	c.541G>A	c.(541-543)GAG>AAG	p.E181K	TBX2_uc002ize.2_Missense_Mutation_p.E171K|TBX2_uc002izg.2_Missense_Mutation_p.E27K	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	181	T-box.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						GGCCGACCCTGAGATGCCCAA	0.577													0	0	0	1	0	9	130										A	59479190	G	A	59479190	3	1	68	1	0	0	0	0	1	0	0	0	15652	1291	45	1	547	1	TBX2	17	59479190	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1190448	59479190	21716020	851	21371										
BRIP1	83990	broad.mit.edu	37	chr17	59878667	59878667	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtagggacaaaatatgatgtCagcatcttgtattagttctc	9	6	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:59878667C>T	uc002izk.1	-	8	1228	c.1087G>A	c.(1087-1089)GAC>AAC	p.D363N		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	363	Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						AATATGATGTCAGCATCTTGT	0.408			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	1	0	41	360										T	59878667	C	T	59878667	3	4	68	1	0	0	0	0	1	0	0	0	1514	826	29	1	2714	1	BRIP1	17	59878667	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	399477	59878667	21316543	852	21372										
STRADA	92335	broad.mit.edu	37	chr17	61787958	61787958	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccatgaagtgtgtacagatGagatcttttgcagaacctgc	10	8	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:61787958G>A	uc002jbm.2	-	8	633	c.474C>T	c.(472-474)CTC>CTT	p.L158L	STRADA_uc002jbn.2_Silent_p.L100L|STRADA_uc002jbo.2_Silent_p.L121L|STRADA_uc002jbp.2_Silent_p.L121L|STRADA_uc002jbq.2_Silent_p.L100L|STRADA_uc010wpq.1_Silent_p.L114L|STRADA_uc010wpr.1_Silent_p.L129L|STRADA_uc010ddw.2_Silent_p.L129L|STRADA_uc002jbr.2_Silent_p.L100L	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	158	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						GTGTACAGATGAGATCTTTTG	0.493													0	0	0	1	0	29	128										A	61787958	G	A	61787958	2	1	68	1	0	0	0	0	0	0	0	1	15323	1277	45	1		1	STRADA	17	61787958	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1909291	61787958	19407252	853	21373										
DDX42	11325	broad.mit.edu	37	chr17	61869914	61869914	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccttggaggcattcatggctGaagtggaggcaagtatcaac	13	8	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:61869914G>C	uc002jbu.2	+	4	621	c.364G>C	c.(364-366)GAA>CAA	p.E122Q	DDX42_uc002jbv.2_Missense_Mutation_p.E122Q|DDX42_uc002jbw.1_5'UTR	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	122	Potential.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						ATTCATGGCTGAAGTGGAGGC	0.373													0	0	0	1	0	30	262										C	61869914	G	C	61869914	3	2	68	1	0	0	0	0	1	0	0	0	4362	1291	45	1	370	1	DDX42	17	61869914	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	81956	61869914	19325296	854	21374										
ARSG	22901	broad.mit.edu	37	chr17	66352862	66352862	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccctctttatgaaaacctCaacattgtggagcagccggt	8	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:66352862C>A	uc002jhc.2	+	6	1417	c.621C>A	c.(619-621)CTC>CTA	p.L207L	ARSG_uc002jhb.1_Silent_p.L43L	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	207					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATGAAAACCTCAACATTGTGG	0.502													1	0	2.2171e-23	1	2.55585e-23	33	46										A	66352862	C	A	66352862	2	1	68	1	0	0	0	0	0	0	0	1	992	813	29	3		3	ARSG	17	66352862	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4482948	66352862	14842348	855	21375										
ABCA9	10350	broad.mit.edu	37	chr17	67024685	67024685	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtcttcttacctgatgttgGaactgacaacccactaagta	7	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:67024685G>C	uc002jhu.2	-	12	1749	c.1606C>G	c.(1606-1608)CCA>GCA	p.P536A	ABCA9_uc010dez.2_Missense_Mutation_p.P536A	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	536	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CCTGATGTTGGAACTGACAAC	0.363													0	0	0	1	0	26	82										C	67024685	G	C	67024685	3	2	68	1	0	0	0	0	1	0	0	0	39	1174	41	1	3380	1	ABCA9	17	67024685	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	671823	67024685	14170525	856	21376										
KCNJ2	3759	broad.mit.edu	37	chr17	68171223	68171223	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctacagcatcgtctcttcaGaagaagacggtatgaagttg	11	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:68171223G>T	uc010dfg.2	+	2	444	c.43G>T	c.(43-45)GAA>TAA	p.E15*	KCNJ2_uc002jir.2_Nonsense_Mutation_p.E15*	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	15	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					CGTCTCTTCAGAAGAAGACGG	0.517													1	0	1.52009e-12	1	1.71316e-12	16	64										T	68171223	G	T	68171223	4	4	68	1	0	0	0	0	0	1	0	0	8051	943	33	3	45	3	KCNJ2	17	68171223	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1146538	68171223	13023987	857	21377										
RAB37	326624	broad.mit.edu	37	chr17	72739323	72739323	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgtcacccatgcttattacaGagatgctcagggtgagtccc	10	12	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:72739323G>A	uc002jlk.2	+	4	358	c.302G>A	c.(301-303)AGA>AAA	p.R101K	RAB37_uc002jlc.2_Missense_Mutation_p.R94K|RAB37_uc010dfu.2_Missense_Mutation_p.R94K|RAB37_uc002jld.2_Missense_Mutation_p.R94K|RAB37_uc010wrb.1_Missense_Mutation_p.R69K|RAB37_uc010wrc.1_Missense_Mutation_p.R106K|RAB37_uc010wrd.1_Missense_Mutation_p.R69K|RAB37_uc010wre.1_Missense_Mutation_p.R64K|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	101					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						GCTTATTACAGAGATGCTCAG	0.602													0	0	0	1	0	71	116										A	72739323	G	A	72739323	3	1	68	1	0	0	0	0	1	0	0	0	12927	942	33	1	619	1	RAB37	17	72739323	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4568100	72739323	8455887	858	21378										
SUMO2	6613	broad.mit.edu	37	chr17	73164440	73164440	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcaggttcccttttcagtaGacacctcccgtctgctgttg	9	13	2	1	rs55895120		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:73164440G>C	uc002jne.2	-	4	451	c.282C>G	c.(280-282)GTC>GTG	p.V94V	SUMO2_uc002jnf.2_Silent_p.V70V	NM_006937	NP_008868	P61956	SUMO2_HUMAN	SMT3 suppressor of mif two 3 homolog 2 isoform a	94	Ubiquitin-like.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation	nucleus	ubiquitin protein ligase binding				0	all_lung(278;0.14)|Lung NSC(278;0.168)					CTTTTCAGTAGACACCTCCCG	0.378													0	0	0	1	0	7	27										C	73164440	G	C	73164440	2	2	68	1	0	0	0	0	0	0	0	1	15385	929	33	1		1	SUMO2	17	73164440	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	425117	73164440	8030770	859	21379										
NUP85	79902	broad.mit.edu	37	chr17	73204648	73204648	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaggcgtgaattccaagaaGaaccaaatgtattttgactg	9	8	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:73204648G>C	uc002jng.1	+	2	320	c.60G>C	c.(58-60)AAG>AAC	p.K20N	NUP85_uc010dgd.1_Missense_Mutation_p.K20N|NUP85_uc010wrv.1_Intron	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	20					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			ATTCCAAGAAGAACCAAATGT	0.338													0	0	0	1	0	32	271										C	73204648	G	C	73204648	3	2	68	1	0	0	0	0	1	0	0	0	10770	933	33	1	66	1	NUP85	17	73204648	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	40208	73204648	7990562	860	21380										
SLC25A19	60386	broad.mit.edu	37	chr17	73282415	73282415	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccatagcctatggagagaatCtgagctgggacgtgtccttt	12	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:73282415C>A	uc002jns.3	-	2	1168	c.258G>T	c.(256-258)CAG>CAT	p.Q86H	SLC25A19_uc010dge.2_Missense_Mutation_p.Q86H|SLC25A19_uc002jnv.3_Missense_Mutation_p.Q86H|SLC25A19_uc002jnu.3_Missense_Mutation_p.Q86H|SLC25A19_uc002jnw.3_Missense_Mutation_p.Q86H|SLC25A19_uc002jnt.3_Missense_Mutation_p.Q86H	NM_021734	NP_068380	Q9HC21	TPC_HUMAN	solute carrier family 25, member 19	86	Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			ovary(1)	1	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			TGGAGAGAATCTGAGCTGGGA	0.592													1	0	1.96895e-08	1	2.13684e-08	24	153										A	73282415	C	A	73282415	3	1	68	1	0	0	0	0	1	0	0	0	14481	912	32	3	724	3	SLC25A19	17	73282415	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	77767	73282415	7912795	861	21381										
CCDC40	55036	broad.mit.edu	37	chr17	78059852	78059852	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcaaaaggctgagcaagctGatcgacgagcacgatggcaa	12	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:78059852G>A	uc010dht.2	+	14	2313	c.2286G>A	c.(2284-2286)CTG>CTA	p.L762L	CCDC40_uc002jxm.3_Silent_p.L545L|CCDC40_uc002jxn.3_Silent_p.L158L	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	762	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGAGCAAGCTGATCGACGAGC	0.522													0	0	0	1	0	18	83										A	78059852	G	A	78059852	2	1	68	1	0	0	0	0	0	0	0	1	2812	1277	45	1		1	CCDC40	17	78059852	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4777437	78059852	3135358	862	21382										
SLC38A10	124565	broad.mit.edu	37	chr17	79220394	79220394	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaaggcaggggaggcagattCtccaccgtctccctggcctt	12	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:79220394C>T	uc002jzz.1	-	16	2697	c.2322G>A	c.(2320-2322)GAG>GAA	p.E774E	SLC38A10_uc002jzy.1_Silent_p.E692E	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	774					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GAGGCAGATTCTCCACCGTCT	0.652													0	0	0	1	0	14	70										T	79220394	C	T	79220394	2	4	68	1	0	0	0	0	0	0	0	1	14602	912	32	1		1	SLC38A10	17	79220394	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1160542	79220394	1974816	863	21383										
FASN	2194	broad.mit.edu	37	chr17	80040026	80040026	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtccagctcagggcacgcctCtcgggtcaccctgtgggcac	13	16	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:80040026C>T	uc002kdu.2	-	36	6139	c.6022G>A	c.(6022-6024)GAG>AAG	p.E2008K	FASN_uc002kdv.1_RNA	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	2008	Beta-ketoacyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGGCACGCCTCTCGGGTCACC	0.627													0	0	0	1	0	9	42										T	80040026	C	T	80040026	3	4	68	1	0	0	0	0	1	0	0	0	5683	922	32	1	1545	1	FASN	17	80040026	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	819632	80040026	1155184	864	21384										
UTS2R	2837	broad.mit.edu	37	chr17	80332454	80332454	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctccctgcgtgcggtggcctCcatgtacgtctacgtggtca	12	14	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:80332454C>A	uc010wvl.1	+	1	254	c.254C>A	c.(253-255)TCC>TAC	p.S85Y		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	85	Cytoplasmic (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			GCGGTGGCCTCCATGTACGTC	0.652													1	0	0.150653	1	0.151374	4	11										A	80332454	C	A	80332454	3	1	68	1	0	0	0	0	1	0	0	0	17103	855	30	3	256	3	UTS2R	17	80332454	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	292428	80332454	862756	865	21385										
HEXDC	284004	broad.mit.edu	37	chr17	80377757	80377757	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caaaggtctcgtacctctcaGaggtaaggactcccttttac	8	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:80377757G>A	uc002kew.2	+	1	133	c.82G>A	c.(82-84)GAG>AAG	p.E28K	C17orf101_uc002ket.1_5'Flank|C17orf101_uc002keu.1_5'Flank|C17orf101_uc010dip.1_5'Flank|HEXDC_uc002kev.3_Missense_Mutation_p.E28K|HEXDC_uc010diq.2_Missense_Mutation_p.E28K			Q8WVB3	HEXDC_HUMAN	SubName: Full=Hexosaminidase (Glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_c; SubName: Full=Hexosaminidase D;	28					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			ovary(1)|skin(1)	2	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GTACCTCTCAGAGGTAAGGAC	0.418													0	0	0	1	0	16	27										A	80377757	G	A	80377757	3	1	68	1	0	0	0	0	1	0	0	0	7075	943	33	1	84	1	HEXDC	17	80377757	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	45303	80377757	817453	866	21386										
HEXDC	284004	broad.mit.edu	37	chr17	80391557	80391557	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgctgaagcacacggccttCgcccacctgcgggaggtggg	16	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr17:80391557C>T	uc002kew.2	+	4	357	c.306C>T	c.(304-306)TTC>TTT	p.F102F	HEXDC_uc002kev.3_Silent_p.F102F|HEXDC_uc010diq.2_Silent_p.F102F|HEXDC_uc010wvm.1_RNA			Q8WVB3	HEXDC_HUMAN	SubName: Full=Hexosaminidase (Glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_c; SubName: Full=Hexosaminidase D;	102					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			ovary(1)|skin(1)	2	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			ACACGGCCTTCGCCCACCTGC	0.652													0	0	0	1	0	17	56										T	80391557	C	T	80391557	2	4	68	1	0	0	0	0	0	0	0	1	7075	883	31	1		1	HEXDC	17	80391557	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	13800	80391557	803653	867	21387										
LAMA1	284217	broad.mit.edu	37	chr18	7010382	7010382	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtttgccaccataggccatGagctatcaaataataaagtg	8	8	1	1	rs139372717		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:7010382G>C	uc002knm.2	-	26	3784	c.3690C>G	c.(3688-3690)CTC>CTG	p.L1230L	LAMA1_uc010wzj.1_Silent_p.L706L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1230	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CATAGGCCATGAGCTATCAAA	0.408													0	0	0	1	0	29	80										C	7010382	G	C	7010382	2	2	68	1	0	0	0	0	0	0	0	1	8605	1277	45	1		1	LAMA1	18	7010382	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		7010382	71066866	868	21388										
LAMA1	284217	broad.mit.edu	37	chr18	7080413	7080413	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccacaggtggcattggtgctGatgtgagcattgctggcaag	15	8	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:7080413G>A	uc002knm.2	-	2	199	c.105C>T	c.(103-105)ATC>ATT	p.I35I	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	35	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CATTGGTGCTGATGTGAGCAT	0.517													0	0	0	1	0	23	67										A	7080413	G	A	7080413	2	1	68	1	0	0	0	0	0	0	0	1	8605	1280	45	1		1	LAMA1	18	7080413	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	70031	7080413	70996835	869	21389										
CEP192	55125	broad.mit.edu	37	chr18	13092445	13092445	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catgtgtaaaattatactttCagtaattggagaattcagag	8	4	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:13092445C>T	uc010xac.1	+	34	6253	c.6173C>T	c.(6172-6174)TCA>TTA	p.S2058L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.S1583L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.S480L|CEP192_uc002krw.2_Missense_Mutation_p.S207L|CEP192_uc002krx.2_Missense_Mutation_p.S62L|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2058										ovary(4)|pancreas(1)	5						ATTATACTTTCAGTAATTGGA	0.333													0	0	0	1	0	16	85										T	13092445	C	T	13092445	3	4	68	1	0	0	0	0	1	0	0	0	3251	838	29	1	6303	1	CEP192	18	13092445	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6012032	13092445	64984803	870	21390										
DCC	1630	broad.mit.edu	37	chr18	50832018	50832018	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tattaccggctataaaattcGacacagaaagacgacccgca	7	11	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:50832018G>A	uc002lfe.1	+	13	2569	c.1982G>A	c.(1981-1983)CGA>CAA	p.R661Q	DCC_uc010xdr.1_Missense_Mutation_p.R509Q|DCC_uc010dpf.1_Missense_Mutation_p.R316Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	661	Extracellular (Potential).|Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.R661*(1)		skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TATAAAATTCGACACAGAAAG	0.423													0	0	0	1	0	20	55										A	50832018	G	A	50832018	3	1	68	1	0	0	0	0	1	0	0	0	4282	1058	37	1	2032	1	DCC	18	50832018	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	37739573	50832018	27245230	871	21391										
ATP8B1	5205	broad.mit.edu	37	chr18	55342102	55342102	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttccggtcactgttgaagtCcaaaatggcaagaacattgt	9	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:55342102C>G	uc002lgw.2	-	15	1783	c.1783G>C	c.(1783-1785)GAC>CAC	p.D595H	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	595	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				CTGTTGAAGTCCAAAATGGCA	0.473									Byler_disease				0	0	0	1	0	30	44										G	55342102	C	G	55342102	3	3	68	1	0	0	0	0	1	0	0	0	1194	855	30	1	2024	1	ATP8B1	18	55342102	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4510084	55342102	22735146	872	21392										
SERPINB13	5275	broad.mit.edu	37	chr18	61264380	61264380	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agccgactactcgggaatgtCgtcaggctccgggttgtacg	14	11	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:61264380C>T	uc002ljc.2	+	8	1127	c.959C>T	c.(958-960)TCG>TTG	p.S320L	SERPINB13_uc002ljd.2_Missense_Mutation_p.S184L|SERPINB13_uc010xep.1_Missense_Mutation_p.S329L|SERPINB13_uc010xeq.1_Missense_Mutation_p.S141L|SERPINB13_uc010xer.1_Missense_Mutation_p.S141L	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	320					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						TCGGGAATGTCGTCAGGCTCC	0.592													0	0	0	1	0	16	93										T	61264380	C	T	61264380	3	4	68	1	0	0	0	0	1	0	0	0	14100	893	31	1	985	1	SERPINB13	18	61264380	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5922278	61264380	16812868	873	21393										
CDH19	28513	broad.mit.edu	37	chr18	64235752	64235752	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttgatgacaaactcagactCaggttccacagcccttccag	7	13	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:64235752C>G	uc002lkc.1	-	3	529	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.E131Q|CDH19_uc002lkd.2_Missense_Mutation_p.E131Q	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	131	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				AACTCAGACTCAGGTTCCACA	0.438													0	0	0	1	0	26	104										G	64235752	C	G	64235752	3	3	68	1	0	0	0	0	1	0	0	0	3104	835	29	1	1967	1	CDH19	18	64235752	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2971372	64235752	13841496	874	21394										
NETO1	81832	broad.mit.edu	37	chr18	70417770	70417770	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acgatgacagagatgataatGaggatgatcacgatgcagga	13	5	1	5			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:70417770G>C	uc002lkw.2	-	9	1352	c.1068C>G	c.(1066-1068)CTC>CTG	p.L356L	NETO1_uc002lkx.1_Silent_p.L355L|NETO1_uc002lky.1_Silent_p.L356L	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	356	Helical; (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		AGATGATAATGAGGATGATCA	0.463													0	0	0	1	0	18	80										C	70417770	G	C	70417770	2	2	68	1	0	0	0	0	0	0	0	1	10339	1277	45	1		1	NETO1	18	70417770	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6182018	70417770	7659478	875	21395										
NETO1	81832	broad.mit.edu	37	chr18	70451007	70451007	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaagacccgtgcgtagcatGacatcattagccacagtgct	9	13	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:70451007G>A	uc002lkw.2	-	7	1058	c.774C>T	c.(772-774)GTC>GTT	p.V258V	NETO1_uc002lkx.1_Silent_p.V257V|NETO1_uc002lky.1_Silent_p.V258V	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	258	CUB 2.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TGCGTAGCATGACATCATTAG	0.473													0	0	0	1	0	154	56										A	70451007	G	A	70451007	2	1	68	1	0	0	0	0	0	0	0	1	10339	1277	45	1		1	NETO1	18	70451007	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	33237	70451007	7626241	876	21396										
ZNF516	9658	broad.mit.edu	37	chr18	74091004	74091004	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgggcctgcaaggccgcgtcGcccctggaccccgcagcaca	13	18	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr18:74091004G>A	uc010dqx.1	-	3	3301	c.3066C>T	c.(3064-3066)GGC>GGT	p.G1022G	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	1022					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		AGGCCGCGTCGCCCCTGGACC	0.731													0	0	0	1	0	7	23										A	74091004	G	A	74091004	2	1	68	1	0	0	0	0	0	0	0	1	17957	1074	38	2		2	ZNF516	18	74091004	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3639997	74091004	3986244	877	21397										
POLRMT	5442	broad.mit.edu	37	chr19	630072	630072	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggctggaggctaccatctCcactgccacattctgggagc	12	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:630072C>G	uc002lpf.1	-	3	346	c.290G>C	c.(289-291)GGA>GCA	p.G97A		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	97					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTACCATCTCCACTGCCACA	0.647													0	0	0	1	0	22	54										G	630072	C	G	630072	3	3	68	1	0	0	0	0	1	0	0	0	12238	855	30	1	3478	1	POLRMT	19	630072	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		630072	58498911	878	21398										
APC2	10297	broad.mit.edu	37	chr19	1466922	1466922	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccccggacagaccatgcctCccagccggagcaagacgcca	11	18	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:1466922C>G	uc002lsr.1	+	15	3830	c.3622C>G	c.(3622-3624)CCC>GCC	p.P1208A	APC2_uc002lss.1_Missense_Mutation_p.P790A|APC2_uc002lst.1_Missense_Mutation_p.P1208A|APC2_uc002lsu.1_Missense_Mutation_p.P1207A|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1208	Interaction with CTNNB1.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCATGCCTCCCAGCCGGAG	0.697													0	0	0	1	0	3	6										G	1466922	C	G	1466922	3	3	68	1	0	0	0	0	1	0	0	0	764	855	30	1	3676	1	APC2	19	1466922	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	836850	1466922	57662061	879	21399										
CSNK1G2	1455	broad.mit.edu	37	chr19	1978737	1978737	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcaagacggtgctgatgatCgccatccagctggtgcgcgg	14	12	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:1978737C>T	uc002lul.3	+	6	958	c.435C>T	c.(433-435)ATC>ATT	p.I145I	CSNK1G2_uc010dsu.2_Silent_p.I97I	NM_001319	NP_001310	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	145	Protein kinase.				sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			stomach(1)	1		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTGATGATCGCCATCCAGC	0.388													0	0	0	1	0	3	4										T	1978737	C	T	1978737	2	4	68	1	0	0	0	0	0	0	0	1	3955	874	31	1		1	CSNK1G2	19	1978737	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	511815	1978737	57150246	880	21400										
DOT1L	84444	broad.mit.edu	37	chr19	2226780	2226780	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgggaccgcgaggtcgacctCaagaatggccacaacctctt	11	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:2226780C>G	uc002lvb.3	+	27	4296	c.4260C>G	c.(4258-4260)CTC>CTG	p.L1420L	DOT1L_uc002lvc.1_Silent_p.L714L	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1420						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTCGACCTCAAGAATGGCC	0.741													0	0	0	1	0	4	10										G	2226780	C	G	2226780	2	3	68	1	0	0	0	0	0	0	0	1	4709	813	29	1		1	DOT1L	19	2226780	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	248043	2226780	56902203	881	21401										
THOP1	7064	broad.mit.edu	37	chr19	2794783	2794783	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagaggaatatccttgactTcccccagcatgtttccccct	6	15	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:2794783T>C	uc002lwj.2	+	3	406	c.251T>C	c.(250-252)TTC>TCC	p.F84S	THOP1_uc010xgz.1_5'Flank	NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	84					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCCTTGACTTCCCCCAGCAT	0.577													0	0	0	1	0	73	141										C	2794783	T	C	2794783	3	2	68	1	0	0	0	0	1	0	0	0	15868	1783	62	5	261	5	THOP1	19	2794783	Missense_Mutation	SNP	T	TCGA-DK-A3X1-01A-12D-A22Z-08	568003	2794783	56334200	882	21402										
CELF5	60680	broad.mit.edu	37	chr19	3284910	3284910	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgcccgcagctcagagcccGactgtggccgagacactgca	12	16	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:3284910G>C	uc002lxm.2	+	9	1087	c.1050G>C	c.(1048-1050)CCG>CCC	p.P350P	CELF5_uc002lxl.1_Silent_p.P350P|CELF5_uc010dtj.1_Silent_p.P325P|CELF5_uc010xhg.1_Silent_p.P236P|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	350					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						CTCAGAGCCCGACTGTGGCCG	0.502													0	0	0	1	0	5	12										C	3284910	G	C	3284910	2	2	68	1	0	0	0	0	0	0	0	1	3219	1045	37	1		1	CELF5	19	3284910	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	490127	3284910	55844073	883	21403										
ZFR2	23217	broad.mit.edu	37	chr19	3816809	3816809	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caggatgcctactcgcatgaCgcctttcaggacccgagtct	10	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:3816809C>T	uc002lyw.2	-	13	1978	c.1966G>A	c.(1966-1968)GTC>ATC	p.V656I		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	656						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		ACTCGCATGACGCCTTTCAGG	0.388													0	0	0	1	0	3	5										T	3816809	C	T	3816809	3	4	68	1	0	0	0	0	1	0	0	0	17657	536	19	2	881	2	ZFR2	19	3816809	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	531899	3816809	55312174	884	21404										
EEF2	1938	broad.mit.edu	37	chr19	3979971	3979971	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggtgatggtgcccgtcttCaccaggaactggtccacgcc	13	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:3979971C>A	uc002lze.2	-	10	1523	c.1440G>T	c.(1438-1440)GTG>GTT	p.V480V		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	480						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCCCGTCTTCACCAGGAACT	0.592													1	0	0.00198382	1	0.0020207	7	29										A	3979971	C	A	3979971	2	1	68	1	0	0	0	0	0	0	0	1	4929	813	29	3		3	EEF2	19	3979971	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	163162	3979971	55149012	885	21405										
MLLT1	4298	broad.mit.edu	37	chr19	6230705	6230705	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggaacaggtcgtaggtgaagCagaccttcctcggctcctcc	12	13	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:6230705C>T	uc002mek.2	-	4	460	c.296G>A	c.(295-297)TGC>TAC	p.C99Y		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	99	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						GTAGGTGAAGCAGACCTTCCT	0.597			T	MLL	AL								0	0	0	1	0	30	131										T	6230705	C	T	6230705	3	4	68	1	0	0	0	0	1	0	0	0	9625	710	25	2	1419	2	MLLT1	19	6230705	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2250734	6230705	52898278	886	21406										
ZNF557	79230	broad.mit.edu	37	chr19	7083276	7083276	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aatgtaaccagtgttttcgtGagttccgcactcagtcaatc	8	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:7083276G>T	uc002mgb.2	+	8	1278	c.793G>T	c.(793-795)GAG>TAG	p.E265*	ZNF557_uc002mga.2_Nonsense_Mutation_p.E272*|ZNF557_uc002mgc.2_Nonsense_Mutation_p.E272*	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	265	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		GTGTTTTCGTGAGTTCCGCAC	0.468													1	0	1.01871e-10	1	1.1319e-10	20	80										T	7083276	G	T	7083276	4	4	68	1	0	0	0	0	0	1	0	0	17985	1291	45	3	836	3	ZNF557	19	7083276	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	852571	7083276	52045707	887	21407										
CLEC4G	339390	broad.mit.edu	37	chr19	7794775	7794775	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccagatggcgcacagccctCaggcccagccagtaaccacg	10	18	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:7794775C>G	uc002mhp.3	-	8	744	c.675G>C	c.(673-675)CTG>CTC	p.L225L		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	225	Extracellular (Potential).|C-type lectin.					integral to membrane	protein binding|sugar binding				0						GCACAGCCCTCAGGCCCAGCC	0.647													0	0	0	1	0	9	53										G	7794775	C	G	7794775	2	3	68	1	0	0	0	0	0	0	0	1	3517	813	29	1		1	CLEC4G	19	7794775	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	711499	7794775	51334208	888	21408										
MAP2K7	5609	broad.mit.edu	37	chr19	7968896	7968896	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctgaagcaggagaaccggGaggcccggcggaggatcgac	18	10	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:7968896G>A	uc002mit.2	+	1	132	c.67G>A	c.(67-69)GAG>AAG	p.E23K	MAP2K7_uc002mis.1_Missense_Mutation_p.E23K|MAP2K7_uc002miv.2_Missense_Mutation_p.E23K|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.E23K|MAP2K7_uc010dvv.2_5'UTR	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	23	Potential.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	GGAGAACCGGGAGGCCCGGCG	0.388													0	0	0	1	0	6	7										A	7968896	G	A	7968896	3	1	68	1	0	0	0	0	1	0	0	0	9242	1175	41	1	69	1	MAP2K7	19	7968896	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	174121	7968896	51160087	889	21409										
ICAM1	3383	broad.mit.edu	37	chr19	10385665	10385665	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtgctattcaaactgccctGatgggcagtcaacagctaaa	9	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:10385665G>C	uc002mnq.2	+	2	611	c.292G>C	c.(292-294)GAT>CAT	p.D98H	ICAM1_uc010xle.1_Intron	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	98	Extracellular (Potential).|Ig-like C2-type 1.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	AAACTGCCCTGATGGGCAGTC	0.542													0	0	0	1	0	29	128										C	10385665	G	C	10385665	3	2	68	1	0	0	0	0	1	0	0	0	7479	1290	45	1	298	1	ICAM1	19	10385665	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2416769	10385665	48743318	890	21410										
C19orf52	90580	broad.mit.edu	37	chr19	11040315	11040315	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gagcaggtcttgcagaaggaGaagaaggacaggctcgccct	15	9	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:11040315G>T	uc002mqd.1	+	2	795	c.720G>T	c.(718-720)GAG>GAT	p.E240D	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	240											0						TGCAGAAGGAGAAGAAGGACA	0.632													1	0	3.27435e-08	1	3.53832e-08	14	17										T	11040315	G	T	11040315	3	4	68	1	0	0	0	0	1	0	0	0	1934	933	33	3	726	3	C19orf52	19	11040315	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	654650	11040315	48088668	891	21411										
C19orf52	90580	broad.mit.edu	37	chr19	11040364	11040364	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccactcgctggtgcaggcgGaggccccgagatgaaaccct	13	15	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:11040364G>C	uc002mqd.1	+	2	844	c.769G>C	c.(769-771)GAG>CAG	p.E257Q	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	257											0						GGTGCAGGCGGAGGCCCCGAG	0.637													0	0	0	1	0	4	16										C	11040364	G	C	11040364	3	2	68	1	0	0	0	0	1	0	0	0	1934	1175	41	1	775	1	C19orf52	19	11040364	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	49	11040364	48088619	892	21412										
ZNF440	126070	broad.mit.edu	37	chr19	11943309	11943309	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagatatgtgaataaccttCaaagtcatgaaaggacacaa	7	7	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:11943309C>T	uc002msp.1	+	4	1474	c.1318C>T	c.(1318-1320)CAA>TAA	p.Q440*		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	440	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAATAACCTTCAAAGTCATGA	0.398													0	0	0	1	0	12	77										T	11943309	C	T	11943309	4	4	68	1	0	0	0	0	0	1	0	0	17910	827	29	1	1332	1	ZNF440	19	11943309	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	902945	11943309	47185674	893	21413										
ASF1B	55723	broad.mit.edu	37	chr19	14232376	14232376	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggcttcatgggcgggttctCacgcagctcagggttgaggt	16	9	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:14232376C>T	uc002mye.2	-	3	542	c.370G>A	c.(370-372)GAG>AAG	p.E124K		NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	124	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						GGCGGGTTCTCACGCAGCTCA	0.557													0	0	0	1	0	14	81										T	14232376	C	T	14232376	3	4	68	1	0	0	0	0	1	0	0	0	1038	835	29	1	246	1	ASF1B	19	14232376	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2289067	14232376	44896607	894	21414			2	95		3	3	83	N	G_C	3.691351e-06
ASF1B	55723	broad.mit.edu	37	chr19	14232407	14232407	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggttgaggtactcgttgttGacgtagtagcccactcggat	14	8	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:14232407G>C	uc002mye.2	-	3	511	c.339C>G	c.(337-339)GTC>GTG	p.V113V		NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	113	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						ACTCGTTGTTGACGTAGTAGC	0.577													0	0	0	1	0	12	68										C	14232407	G	C	14232407	2	2	68	1	0	0	0	0	0	0	0	1	1038	1277	45	1		1	ASF1B	19	14232407	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	31	14232407	44896576	895	21415			2	95		3	3	83	N	G_C	3.691351e-06
ASF1B	55723	broad.mit.edu	37	chr19	14232458	14232458	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccatggtaggtgcaggtgatGaggaccacagtcacacccac	12	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:14232458G>A	uc002mye.2	-	3	460	c.288C>T	c.(286-288)CTC>CTT	p.L96L		NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	96	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						TGCAGGTGATGAGGACCACAG	0.592													0	0	0	1	0	9	44										A	14232458	G	A	14232458	2	1	68	1	0	0	0	0	0	0	0	1	1038	1277	45	1		1	ASF1B	19	14232458	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	51	14232458	44896525	896	21416			2	95		3	3	83	N	G_C	3.691351e-06
EMR2	30817	broad.mit.edu	37	chr19	14876511	14876511	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggttattcgggattccgtgtCtgggcttccagcctgggcgg	16	10	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:14876511C>A	uc002mzp.1	-	8	1196	c.740G>T	c.(739-741)AGA>ATA	p.R247I	EMR2_uc010dzs.1_5'Flank|EMR2_uc010xnw.1_Missense_Mutation_p.R247I|EMR2_uc002mzo.1_Missense_Mutation_p.R247I|EMR2_uc002mzq.1_Missense_Mutation_p.R198I|EMR2_uc002mzr.1_Missense_Mutation_p.R198I|EMR2_uc002mzs.1_Intron|EMR2_uc002mzt.1_Missense_Mutation_p.R154I|EMR2_uc002mzu.1_Missense_Mutation_p.R154I|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	247	EGF-like 5; calcium-binding (Potential).|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GATTCCGTGTCTGGGCTTCCA	0.607													1	0	9.16793e-09	1	9.97547e-09	10	66										A	14876511	C	A	14876511	3	1	68	1	0	0	0	0	1	0	0	0	5105	913	32	3	1787	3	EMR2	19	14876511	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	644053	14876511	44252472	897	21417										
OR7C2	26658	broad.mit.edu	37	chr19	15053121	15053121	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taggacaagtctggcagcctCggtgatgtacaccatggtca	12	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:15053121C>T	uc010xoc.1	+	1	821	c.821C>T	c.(820-822)TCG>TTG	p.S274L		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					CTGGCAGCCTCGGTGATGTAC	0.557													0	0	0	1	0	27	95										T	15053121	C	T	15053121	3	4	68	1	0	0	0	0	1	0	0	0	11218	893	31	1	823	1	OR7C2	19	15053121	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	176610	15053121	44075862	898	21418										
EPHX3	79852	broad.mit.edu	37	chr19	15342142	15342142	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catccgaggggccatagcctCgcaagtccacagccacaaca	9	16	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:15342142C>T	uc002nap.2	-	3	604	c.395G>A	c.(394-396)CGA>CAA	p.R132Q	EPHX3_uc002naq.2_Missense_Mutation_p.R132Q	NM_024794	NP_079070	Q9H6B9	EPHX3_HUMAN	abhydrolase domain containing 9 precursor	132						extracellular region	hydrolase activity				0						GCCATAGCCTCGCAAGTCCAC	0.617													0	0	0	1	0	11	34										T	15342142	C	T	15342142	3	4	68	1	0	0	0	0	1	0	0	0	5181	884	31	1	707	1	EPHX3	19	15342142	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	289021	15342142	43786841	899	21419										
EPS15L1	58513	broad.mit.edu	37	chr19	16495955	16495955	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttaccttggacatctggctGaagtcggcaaagccttcagc	10	11	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:16495955G>A	uc002ndz.1	-	21	2238	c.2232C>T	c.(2230-2232)TTC>TTT	p.F744F	EPS15L1_uc002ndx.2_Silent_p.F744F|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.F634F|EPS15L1_uc010xpf.1_Silent_p.F647F|EPS15L1_uc002nea.1_Silent_p.F744F|EPS15L1_uc010eah.1_Silent_p.F746F	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	744	15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						ACATCTGGCTGAAGTCGGCAA	0.542													0	0	0	1	0	76	92										A	16495955	G	A	16495955	2	1	68	1	0	0	0	0	0	0	0	1	5193	1281	45	1		1	EPS15L1	19	16495955	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1153813	16495955	42633028	900	21420										
EPS15L1	58513	broad.mit.edu	37	chr19	16528407	16528407	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgatgtcatcaagctccttCacgccagtaaactccccgga	7	15	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:16528407C>T	uc002ndz.1	-	12	1155	c.1149G>A	c.(1147-1149)GTG>GTA	p.V383V	EPS15L1_uc002ndx.2_Silent_p.V383V|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.V273V|EPS15L1_uc010xpf.1_Silent_p.V286V|EPS15L1_uc002nea.1_Silent_p.V383V|EPS15L1_uc010eah.1_Silent_p.V383V|EPS15L1_uc002neb.1_Silent_p.V229V|EPS15L1_uc002nec.1_Silent_p.V383V	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	383					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						CAAGCTCCTTCACGCCAGTAA	0.502											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	40										T	16528407	C	T	16528407	2	4	68	1	0	0	0	0	0	0	0	1	5193	813	29	1		1	EPS15L1	19	16528407	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	32452	16528407	42600576	901	21421										
CHERP	10523	broad.mit.edu	37	chr19	16653184	16653184	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccatcggggggcagcggcatCtccatggctccggccgcggg	17	15	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:16653184C>G	uc002nei.1	-	1	80	c.6G>C	c.(4-6)GAG>GAC	p.E2D	MED26_uc002nee.2_Intron|CHERP_uc002nej.2_5'Flank	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	2					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GCAGCGGCATCTCCATGGCTC	0.711													0	0	0	1	0	3	12										G	16653184	C	G	16653184	3	3	68	1	0	0	0	0	1	0	0	0	3336	912	32	1	2812	1	CHERP	19	16653184	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	124777	16653184	42475799	902	21422										
FAM125A	93343	broad.mit.edu	37	chr19	17531000	17531000	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggctggcctggcctggtcgtCggcctctgcacccccgccgc	14	19	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:17531000C>T	uc002ngo.1	+	1	89	c.56C>T	c.(55-57)TCG>TTG	p.S19L	FAM125A_uc002ngn.1_Missense_Mutation_p.S19L|FAM125A_uc002ngp.1_5'Flank|FAM125A_uc002ngq.1_5'Flank	NM_138401	NP_612410	Q96EY5	F125A_HUMAN	family with sequence similarity 125, member A	19	MABP.				protein transport	late endosome membrane|microtubule organizing center|nucleus	SH3 domain binding				0						GCCTGGTCGTCGGCCTCTGCA	0.766													0	0	0	1	0	3	8										T	17531000	C	T	17531000	3	4	68	1	0	0	0	0	1	0	0	0	5427	893	31	1	58	1	FAM125A	19	17531000	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	877816	17531000	41597983	903	21423										
FCHO1	23149	broad.mit.edu	37	chr19	17895552	17895552	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agttctcccgcccgggtcccCagtctgtgcctctgcagctc	10	18	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:17895552C>G	uc010ebb.2	+	25	2434	c.2245C>G	c.(2245-2247)CAG>GAG	p.Q749E	FCHO1_uc002nhg.3_Missense_Mutation_p.Q749E|FCHO1_uc002nhh.2_Missense_Mutation_p.Q749E|FCHO1_uc010xpw.1_Missense_Mutation_p.Q699E|FCHO1_uc002nhi.2_Missense_Mutation_p.Q205E|FCHO1_uc002nhj.2_Missense_Mutation_p.Q93E	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	749										breast(1)	1						CCCGGGTCCCCAGTCTGTGCC	0.617											OREG0025350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	26	72										G	17895552	C	G	17895552	3	3	68	1	0	0	0	0	1	0	0	0	5787	595	21	4	2335	4	FCHO1	19	17895552	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	364552	17895552	41233431	904	21424										
ZNF536	9745	broad.mit.edu	37	chr19	31039181	31039181	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggtcccctcagatgctctGaaaggcactgaccttccttc	9	14	2	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:31039181G>A	uc002nsu.1	+	4	2793	c.2655G>A	c.(2653-2655)CTG>CTA	p.L885L	ZNF536_uc010edd.1_Silent_p.L885L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	885					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAGATGCTCTGAAAGGCACTG	0.552													0	0	0	1	0	34	144										A	31039181	G	A	31039181	2	1	68	1	0	0	0	0	0	0	0	1	17971	1277	45	1		1	ZNF536	19	31039181	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	13143629	31039181	28089802	905	21425										
TSHZ3	57616	broad.mit.edu	37	chr19	31768677	31768677	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccatccttgcacccatcccgCggggggctggggctgttctc	13	16	1	0	rs151270303		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:31768677C>T	uc002nsy.3	-	2	2087	c.2022G>A	c.(2020-2022)CCG>CCA	p.P674P		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	674					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					ACCCATCCCGCGGGGGGCTGG	0.657													0	0	0	1	0	12	65										T	31768677	C	T	31768677	2	4	68	1	0	0	0	0	0	0	0	1	16622	755	27	2		2	TSHZ3	19	31768677	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	729496	31768677	27360306	906	21426										
PDCD2L	84306	broad.mit.edu	37	chr19	34912527	34912527	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccaaaggatatttgagtttCagcttatgccagcactggtc	10	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:34912527C>T	uc002nvj.2	+	6	934	c.901C>T	c.(901-903)CAG>TAG	p.Q301*		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	301						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			ATTTGAGTTTCAGCTTATGCC	0.453													0	0	0	1	0	54	142										T	34912527	C	T	34912527	4	4	68	1	0	0	0	0	0	1	0	0	11620	827	29	1	923	1	PDCD2L	19	34912527	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3143850	34912527	24216456	907	21427										
PDCD2L	84306	broad.mit.edu	37	chr19	34912556	34912556	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccagcactggtcagcatgctCaagagtgctaatttaggtga	11	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:34912556C>T	uc002nvj.2	+	6	963	c.930C>T	c.(928-930)CTC>CTT	p.L310L		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	310						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TCAGCATGCTCAAGAGTGCTA	0.408													0	0	0	1	0	50	137										T	34912556	C	T	34912556	2	4	68	1	0	0	0	0	0	0	0	1	11620	813	29	1		1	PDCD2L	19	34912556	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	29	34912556	24216427	908	21428										
GAPDHS	26330	broad.mit.edu	37	chr19	36024442	36024442	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aagaggccatgtcgaagcgcGacatcgtcctcaccaatgtc	10	13	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:36024442G>A	uc002oaf.1	+	1	129	c.13G>A	c.(13-15)GAC>AAC	p.D5N		NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	5					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	GTCGAAGCGCGACATCGTCCT	0.627													0	0	0	1	0	20	59										A	36024442	G	A	36024442	3	1	68	1	0	0	0	0	1	0	0	0	6237	1058	37	1	15	1	GAPDHS	19	36024442	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1111886	36024442	23104541	909	21429										
APLP1	333	broad.mit.edu	37	chr19	36365501	36365501	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acccgcgtcatcgcccttatCaacgaccagcgccgggctgc	10	18	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:36365501C>T	uc002oce.2	+	9	1290	c.1152C>T	c.(1150-1152)ATC>ATT	p.I384I	APLP1_uc010xsz.1_Silent_p.I345I|APLP1_uc002ocf.2_Silent_p.I384I|APLP1_uc002ocg.2_Silent_p.I287I|APLP1_uc010xta.1_Silent_p.I378I	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	384	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCGCCCTTATCAACGACCAGC	0.662													0	0	0	1	0	22	99										T	36365501	C	T	36365501	2	4	68	1	0	0	0	0	0	0	0	1	778	816	29	1		1	APLP1	19	36365501	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	341059	36365501	22763482	910	21430										
ZNF781	163115	broad.mit.edu	37	chr19	38160085	38160085	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attagatgtgcattatgcttGaaggccttcttgcattactg	9	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:38160085G>A	uc002ogy.2	-	4	1707	c.965C>T	c.(964-966)TCA>TTA	p.S322L	ZNF781_uc002ogz.2_Missense_Mutation_p.S317L	NM_152605	NP_689818	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATTATGCTTGAAGGCCTTCT	0.378													0	0	0	1	0	64	115										A	38160085	G	A	38160085	3	1	68	1	0	0	0	0	1	0	0	0	18151	1294	45	1	22	1	ZNF781	19	38160085	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1794584	38160085	20968898	911	21431										
DPF1	8193	broad.mit.edu	37	chr19	38713255	38713255	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccacgccggtctgcgagtcGaggaagggcagtcgcaggct	17	12	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:38713255G>A	uc002ohl.2	-	2	231	c.204C>T	c.(202-204)CTC>CTT	p.L68L	DPF1_uc002ohm.2_Silent_p.L68L|DPF1_uc002ohn.2_5'UTR|DPF1_uc010xtu.1_Silent_p.L42L|DPF1_uc010xtv.1_Silent_p.L42L|DPF1_uc010xtw.1_Silent_p.L42L	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	68					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TCTGCGAGTCGAGGAAGGGCA	0.647													0	0	0	1	0	4	9										A	38713255	G	A	38713255	2	1	68	1	0	0	0	0	0	0	0	1	4716	1045	37	1		1	DPF1	19	38713255	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	553170	38713255	20415728	912	21432										
SUPT5H	6829	broad.mit.edu	37	chr19	39963713	39963713	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgtgtggagctgcactccacCtgccagaccatctctgtgga	11	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:39963713C>A	uc002olo.3	+	23	2396	c.2217C>A	c.(2215-2217)ACC>ACA	p.T739T	SUPT5H_uc002olp.3_Silent_p.T739T|SUPT5H_uc002olq.3_Silent_p.T735T|SUPT5H_uc002oln.3_Silent_p.T739T|SUPT5H_uc002olr.3_Silent_p.T739T|SUPT5H_uc002ols.1_Silent_p.T362T|SUPT5H_uc010egp.1_Silent_p.T105T	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	739					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGCACTCCACCTGCCAGACCA	0.667													1	0	0.000673444	1	0.000690993	10	57										A	39963713	C	A	39963713	2	1	68	1	0	0	0	0	0	0	0	1	15396	668	24	4		4	SUPT5H	19	39963713	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1250458	39963713	19165270	913	21433										
SUPT5H	6829	broad.mit.edu	37	chr19	39963872	39963872	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcgcccgggcggcatgacctCgacctatgggaggacgccca	15	15	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:39963872C>A	uc002olo.3	+	24	2467	c.2288C>A	c.(2287-2289)TCG>TAG	p.S763*	SUPT5H_uc002olp.3_Nonsense_Mutation_p.S763*|SUPT5H_uc002olq.3_Nonsense_Mutation_p.S759*|SUPT5H_uc002oln.3_Nonsense_Mutation_p.S763*|SUPT5H_uc002olr.3_Nonsense_Mutation_p.S763*|SUPT5H_uc002ols.1_Nonsense_Mutation_p.S386*|SUPT5H_uc010egp.1_Silent_p.L128L	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	763	CTR1-2.|9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCATGACCTCGACCTATGGG	0.652													1	0	5.01169e-05	1	5.22743e-05	16	92										A	39963872	C	A	39963872	4	1	68	1	0	0	0	0	0	1	0	0	15396	893	31	3	2378	3	SUPT5H	19	39963872	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	159	39963872	19165111	914	21434										
SELV	348303	broad.mit.edu	37	chr19	40009746	40009746	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgaacgagtccaggctgcaGaaaattgtgagcgttatcga	13	7	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:40009746G>A	uc010xvc.1	+	6	1099	c.999G>A	c.(997-999)CAG>CAA	p.Q333Q		NM_182704	NP_874363	P59797	SELV_HUMAN	selenoprotein V	333					cell redox homeostasis		selenium binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCAGGCTGCAGAAAATTGTGA	0.597													0	0	0	1	0	10	61										A	40009746	G	A	40009746	2	1	68	1	0	0	0	0	0	0	0	1	14023	933	33	1		1	SELV	19	40009746	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	45874	40009746	19119237	915	21435										
PLD3	23646	broad.mit.edu	37	chr19	40872415	40872415	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agcctaaactgatgtaccagGaggtaggtggattggggggc	17	6	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:40872415G>T	uc002onm.3	+	3	423	c.25G>T	c.(25-27)GAG>TAG	p.E9*	PLD3_uc002onj.3_Nonsense_Mutation_p.E9*|PLD3_uc002onk.3_Nonsense_Mutation_p.E9*|PLD3_uc002onl.3_Nonsense_Mutation_p.E9*|PLD3_uc002onn.2_Nonsense_Mutation_p.E9*|PLD3_uc002ono.2_Nonsense_Mutation_p.E9*	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	9	Cytoplasmic (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			GATGTACCAGGAGGTAGGTGG	0.597													1	0	7.45023e-12	1	8.35168e-12	20	55										T	40872415	G	T	40872415	4	4	68	1	0	0	0	0	0	1	0	0	12047	1175	41	3	27	3	PLD3	19	40872415	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	862669	40872415	18256568	916	21436										
CYP2A13	1553	broad.mit.edu	37	chr19	41594955	41594955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggctgaggagttcagcgggcGaggcgagcaggccaccttcg	18	11	1	1	rs148044792		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:41594955G>A	uc002opt.2	+	2	311	c.302G>A	c.(301-303)CGA>CAA	p.R101Q		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	101			R -> Q (in allele CYP2A13*4).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	TTCAGCGGGCGAGGCGAGCAG	0.642													0	0	0	1	0	16	65										A	41594955	G	A	41594955	3	1	68	1	0	0	0	0	1	0	0	0	4161	1058	37	1	308	1	CYP2A13	19	41594955	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	722540	41594955	17534028	917	21437										
CYP2F1	1572	broad.mit.edu	37	chr19	41633861	41633861	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atggagctctttctgtacctCaccgccatcctgcagagctt	8	14	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:41633861C>A	uc002opu.1	+	10	1406	c.1350C>A	c.(1348-1350)CTC>CTA	p.L450L	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	450					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						TTCTGTACCTCACCGCCATCC	0.647													1	0	0.004672	1	0.00473971	3	17										A	41633861	C	A	41633861	2	1	68	1	0	0	0	0	0	0	0	1	4171	813	29	3		3	CYP2F1	19	41633861	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	38906	41633861	17495122	918	21438										
CYP2S1	29785	broad.mit.edu	37	chr19	41709440	41709440	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acccgcctcccttacaccgaCgcggttctgcatgaggcgca	10	17	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:41709440C>T	uc002opw.2	+	7	1117	c.1062C>T	c.(1060-1062)GAC>GAT	p.D354D	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Silent_p.D79D	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	354					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						CTTACACCGACGCGGTTCTGC	0.672													0	0	0	1	0	4	12										T	41709440	C	T	41709440	2	4	68	1	0	0	0	0	0	0	0	1	4174	535	19	2		2	CYP2S1	19	41709440	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	75579	41709440	17419543	919	21439										
ARHGEF1	9138	broad.mit.edu	37	chr19	42399472	42399472	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggcgtggggatgccctctCgggaccggaatatcggggct	18	10	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:42399472C>T	uc002orx.2	+	12	1037	c.928C>T	c.(928-930)CGG>TGG	p.R310W	ARHGEF1_uc002orw.1_Missense_Mutation_p.R310W|ARHGEF1_uc002ory.2_Missense_Mutation_p.R277W|ARHGEF1_uc002orz.2_Missense_Mutation_p.R148W|ARHGEF1_uc002osa.2_Missense_Mutation_p.R325W|ARHGEF1_uc002osb.2_Missense_Mutation_p.R292W|ARHGEF1_uc002osc.2_Missense_Mutation_p.R4W|ARHGEF1_uc002osd.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	310					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GATGCCCTCTCGGGACCGGAA	0.607													0	0	0	1	0	50	103										T	42399472	C	T	42399472	3	4	68	1	0	0	0	0	1	0	0	0	893	875	31	1	1019	1	ARHGEF1	19	42399472	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	690032	42399472	16729511	920	21440										
ARHGEF1	9138	broad.mit.edu	37	chr19	42410099	42410099	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccccaatccagcccggaccGagagaatcctcagtgacctc	8	17	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:42410099G>A	uc002orx.2	+	26	2522	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K	ARHGEF1_uc002ory.2_Missense_Mutation_p.E772K|ARHGEF1_uc002orz.2_Missense_Mutation_p.E643K|ARHGEF1_uc002osa.2_Missense_Mutation_p.E820K|ARHGEF1_uc002osb.2_Missense_Mutation_p.E787K|ARHGEF1_uc002osc.2_Missense_Mutation_p.E559K|ARHGEF1_uc002osd.2_Missense_Mutation_p.E464K|ARHGEF1_uc002ose.2_Missense_Mutation_p.E249K	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	805					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		AGCCCGGACCGAGAGAATCCT	0.667													0	0	0	1	0	21	67										A	42410099	G	A	42410099	3	1	68	1	0	0	0	0	1	0	0	0	893	1059	37	1	2560	1	ARHGEF1	19	42410099	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10627	42410099	16718884	921	21441										
CEACAM1	634	broad.mit.edu	37	chr19	43026086	43026086	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agatactcacaggtgacattCaaggtgactgggtcactgcg	12	9	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:43026086C>T	uc002otv.2	-	3	806	c.693G>A	c.(691-693)TTG>TTA	p.L231L	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_5'Flank|CEACAM1_uc002otw.2_Silent_p.L231L|CEACAM1_uc010eij.2_Silent_p.L231L|CEACAM1_uc002otx.2_Silent_p.L231L|CEACAM1_uc002oty.2_Silent_p.L231L|CEACAM1_uc002otz.2_Silent_p.L231L|CEACAM1_uc010eik.2_Intron|CEACAM1_uc002oua.2_Silent_p.L231L|CEACAM1_uc002oub.2_Silent_p.L231L|CEACAM1_uc002ouc.2_Silent_p.L231L	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	231	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)	AGGTGACATTCAAGGTGACTG	0.552													0	0	0	1	0	28	184										T	43026086	C	T	43026086	2	4	68	1	0	0	0	0	0	0	0	1	3187	825	29	1		1	CEACAM1	19	43026086	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	615987	43026086	16102897	922	21442										
C19orf61	56006	broad.mit.edu	37	chr19	44244303	44244303	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcttgggtaataaagaagtCgatgccactggtctggttgc	12	7	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:44244303C>G	uc002oxj.2	-	7	1112	c.769G>C	c.(769-771)GAC>CAC	p.D257H	C19orf61_uc002oxk.2_Missense_Mutation_p.D257H|C19orf61_uc010eiy.1_Missense_Mutation_p.D257H	NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	257					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				ATAAAGAAGTCGATGCCACTG	0.572													0	0	0	1	0	40	103										G	44244303	C	G	44244303	3	3	68	1	0	0	0	0	1	0	0	0	1943	884	31	1	825	1	C19orf61	19	44244303	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1218217	44244303	14884680	923	21443										
ZNF225	7768	broad.mit.edu	37	chr19	44636229	44636229	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaaaaccatttaaatgtgaaGaatgtgggaaaagatttact	8	3	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:44636229G>C	uc002oyj.1	+	5	1705	c.1462G>C	c.(1462-1464)GAA>CAA	p.E488Q	ZNF225_uc010eje.1_Missense_Mutation_p.E405Q|ZNF225_uc010ejf.1_Missense_Mutation_p.E488Q	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	488	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TAAATGTGAAGAATGTGGGAA	0.393													0	0	0	1	0	27	83										C	44636229	G	C	44636229	3	2	68	1	0	0	0	0	1	0	0	0	17776	943	33	1	1476	1	ZNF225	19	44636229	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	391926	44636229	14492754	924	21444										
NAPA	8775	broad.mit.edu	37	chr19	47991562	47991562	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcttagcgcaggtcctcctCatcgccctggatggtcttct	11	14	3	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:47991562C>T	uc002pha.1	-	11	1171	c.871G>A	c.(871-873)GAG>AAG	p.E291K	uc002pgz.1_Intron|NAPA_uc002phb.1_Missense_Mutation_p.E252K|NAPA_uc002phc.1_Missense_Mutation_p.E178K|NAPA_uc002phd.1_Missense_Mutation_p.E291K	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	291					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		AGGTCCTCCTCATCGCCCTGG	0.632													0	0	0	1	0	17	70										T	47991562	C	T	47991562	3	4	68	1	0	0	0	0	1	0	0	0	10161	835	29	1	20	1	NAPA	19	47991562	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3355333	47991562	11137421	925	21445										
SPHK2	56848	broad.mit.edu	37	chr19	49132306	49132306	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agccccgcccatggcccactCacccctgcatcgttctgtgt	8	19	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:49132306C>A	uc002pjr.2	+	7	1607	c.1241C>A	c.(1240-1242)TCA>TAA	p.S414*	SPHK2_uc010xzt.1_Nonsense_Mutation_p.S355*|SPHK2_uc002pjs.2_Nonsense_Mutation_p.S414*|SPHK2_uc002pjt.2_Nonsense_Mutation_p.S208*|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Nonsense_Mutation_p.S378*|SPHK2_uc002pjw.2_Nonsense_Mutation_p.S476*	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	414					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		atggcccactcacccctgcat	0.338													1	0	4.7546e-09	1	5.20035e-09	17	21										A	49132306	C	A	49132306	4	1	68	1	0	0	0	0	0	1	0	0	15046	838	29	3	1263	3	SPHK2	19	49132306	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1140744	49132306	9996677	926	21446										
RUVBL2	10856	broad.mit.edu	37	chr19	49514296	49514296	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcagaagtccgtgagcagatCaatgccaaggtggctgagtg	14	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:49514296C>T	uc002plr.1	+	10	841	c.828C>T	c.(826-828)ATC>ATT	p.I276I	RUVBL2_uc002plq.1_Silent_p.I231I|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Silent_p.I231I|RUVBL2_uc010yac.1_Silent_p.I231I	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	276					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GTGAGCAGATCAATGCCAAGG	0.637													0	0	0	1	0	6	23										T	49514296	C	T	49514296	2	4	68	1	0	0	0	0	0	0	0	1	13753	816	29	1		1	RUVBL2	19	49514296	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	381990	49514296	9614687	927	21447										
CD37	951	broad.mit.edu	37	chr19	49842010	49842010	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggttccaagtcctcatcctGagaggtaacgggtcggaggc	14	10	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:49842010G>A	uc002pnd.2	+	6	622	c.501G>A	c.(499-501)CTG>CTA	p.L167L	uc002pnb.1_Intron|CD37_uc002pnc.2_RNA|CD37_uc010yam.1_Silent_p.L167L|CD37_uc010yan.1_Silent_p.L99L|CD37_uc002pnf.3_Silent_p.L139L|CD37_uc002pne.2_Silent_p.L99L	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	167	Extracellular (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		TCCTCATCCTGAGAGGTAACG	0.607													0	0	0	1	0	19	108										A	49842010	G	A	49842010	2	1	68	1	0	0	0	0	0	0	0	1	3008	1277	45	1		1	CD37	19	49842010	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	327714	49842010	9286973	928	21448										
FCGRT	2217	broad.mit.edu	37	chr19	50017149	50017149	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtctgcagaaagccacctCtccctcctgtaccaccttac	5	18	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:50017149C>T	uc002poe.2	+	3	570	c.84C>T	c.(82-84)CTC>CTT	p.L28L	FCGRT_uc002pod.2_RNA|FCGRT_uc002pog.2_Silent_p.L28L|FCGRT_uc002pof.1_5'UTR|FCGRT_uc010yax.1_Silent_p.L28L|FCGRT_uc002poh.1_5'Flank	NM_001136019	NP_001129491	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	28	Extracellular (Potential).|Alpha-1.				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		AAAGCCACCTCTCCCTCCTGT	0.612													0	0	0	1	0	72	223										T	50017149	C	T	50017149	2	4	68	1	0	0	0	0	0	0	0	1	5786	900	32	1		1	FCGRT	19	50017149	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	175139	50017149	9111834	929	21449										
SHANK1	50944	broad.mit.edu	37	chr19	51169834	51169834	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acgcagggccagcagcccatCggttccagcccctgtcaccg	11	18	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:51169834C>G	uc002psx.1	-	22	5402	c.5383G>C	c.(5383-5385)GAT>CAT	p.D1795H	SHANK1_uc002psw.1_Missense_Mutation_p.D1179H	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1795					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGCAGCCCATCGGTTCCAGCC	0.721													0	0	0	1	0	4	18										G	51169834	C	G	51169834	3	3	68	1	0	0	0	0	1	0	0	0	14264	884	31	1	1110	1	SHANK1	19	51169834	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1152685	51169834	7959149	930	21450										
ZNF577	84765	broad.mit.edu	37	chr19	52375790	52375790	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggtatcagaagatttattCtgatacaatatctgtaagat	7	5	3	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:52375790C>A	uc010yde.1	-	7	1844	c.1453G>T	c.(1453-1455)GAA>TAA	p.E485*	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Nonsense_Mutation_p.E426*|ZNF577_uc002pxv.2_Nonsense_Mutation_p.E478*|ZNF577_uc002pxw.2_Nonsense_Mutation_p.E419*	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		AAGATTTATTCTGATACAATA	0.373													1	0	0.014758	1	0.0149118	5	18										A	52375790	C	A	52375790	4	1	68	1	0	0	0	0	0	1	0	0	18006	922	32	3	8	3	ZNF577	19	52375790	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1205956	52375790	6753193	931	21451										
PPP2R1A	5518	broad.mit.edu	37	chr19	52719907	52719907	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cccctcttcctggctcagctGaaggatgaggtaagggcacc	12	13	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:52719907G>A	uc002pyp.2	+	9	1278	c.1119G>A	c.(1117-1119)CTG>CTA	p.L373L	PPP2R1A_uc010ydk.1_Silent_p.L318L|PPP2R1A_uc010epm.1_Silent_p.L413L|PPP2R1A_uc002pyq.2_Silent_p.L194L	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	373	PP2A subunit B binding.|HEAT 10.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TGGCTCAGCTGAAGGATGAGG	0.547			Mis		clear cell ovarian carcinoma								0	0	0	1	0	30	50										A	52719907	G	A	52719907	2	1	68	1	0	0	0	0	0	0	0	1	12382	1277	45	1		1	PPP2R1A	19	52719907	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	344117	52719907	6409076	932	21452										
ZNF578	147660	broad.mit.edu	37	chr19	53013953	53013953	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atttttgcttccaggaaattGaaaaagatattcatgacttt	6	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:53013953G>A	uc002pzp.3	+	6	563	c.319G>A	c.(319-321)GAA>AAA	p.E107K		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		CCAGGAAATTGAAAAAGATAT	0.398													0	0	0	1	0	63	166										A	53013953	G	A	53013953	3	1	68	1	0	0	0	0	1	0	0	0	18007	1291	45	1	329	1	ZNF578	19	53013953	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	294046	53013953	6115030	933	21453										
ZNF813	126017	broad.mit.edu	37	chr19	53995335	53995335	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgagtgtggcaaagcttttAattgaaaagcaaagcttgca	10	5	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:53995335A>G	uc002qbu.2	+	4	1977	c.1849A>G	c.(1849-1851)AAT>GAT	p.N617D	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CAAAGCTTTTAATTGAAAAGC	0.373													0	0	0	1	0	7	30										G	53995335	A	G	53995335	3	3	68	1	0	0	0	0	1	0	0	0	18172	362	13	5	1859	5	ZNF813	19	53995335	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	981382	53995335	5133648	934	21454										
OSCAR	126014	broad.mit.edu	37	chr19	54600327	54600327	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggagcgatctctccaggcttGaaaagtccaaatctccaagc	9	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:54600327G>A	uc002qdd.2	-	4	387	c.270C>T	c.(268-270)TTC>TTT	p.F90F	OSCAR_uc002qcy.2_Silent_p.F69F|OSCAR_uc002qcz.2_Silent_p.F65F|OSCAR_uc002qda.2_Silent_p.F69F|OSCAR_uc002qdb.2_Silent_p.F54F|OSCAR_uc010erc.2_Nonsense_Mutation_p.Q33*|OSCAR_uc002qdc.2_Silent_p.F79F	NM_206818	NP_996554	Q8IYS5	OSCAR_HUMAN	osteoclast-associated receptor isoform 1	65	Ig-like 1.					extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)					CTCCAGGCTTGAAAAGTCCAA	0.587													0	0	0	1	0	45	118										A	54600327	G	A	54600327	2	1	68	1	0	0	0	0	0	0	0	1	11285	1281	45	1		1	OSCAR	19	54600327	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	604992	54600327	4528656	935	21455										
PRPF31	26121	broad.mit.edu	37	chr19	54627903	54627903	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccggcggcctgaccaacctCtccaagatgcccgcctgcaa	10	18	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:54627903C>G	uc002qdh.2	+	8	1119	c.723C>G	c.(721-723)CTC>CTG	p.L241L	PRPF31_uc010yek.1_Silent_p.L241L	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	241	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGACCAACCTCTCCAAGATGC	0.647													0	0	0	1	0	12	101										G	54627903	C	G	54627903	2	3	68	1	0	0	0	0	0	0	0	1	12566	900	32	1		1	PRPF31	19	54627903	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	27576	54627903	4501080	936	21456										
LILRA1	11024	broad.mit.edu	37	chr19	55107894	55107894	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gacctacaggtgctacggctCactcagctccaacccctacc	7	18	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:55107894C>T	uc002qgh.1	+	7	1381	c.1199C>T	c.(1198-1200)TCA>TTA	p.S400L	LILRA2_uc010yfg.1_Missense_Mutation_p.S398L|LILRA1_uc010yfh.1_Missense_Mutation_p.S400L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	400	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		TGCTACGGCTCACTCAGCTCC	0.572													0	0	0	1	0	80	136										T	55107894	C	T	55107894	3	4	68	1	0	0	0	0	1	0	0	0	8784	838	29	1	1221	1	LILRA1	19	55107894	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	479991	55107894	4021089	937	21457										
LILRA1	11024	broad.mit.edu	37	chr19	55107923	55107923	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccaacccctacctgctgtctCaccccagtgactccctggag	7	19	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:55107923C>T	uc002qgh.1	+	7	1410	c.1228C>T	c.(1228-1230)CAC>TAC	p.H410Y	LILRA2_uc010yfg.1_Missense_Mutation_p.H408Y|LILRA1_uc010yfh.1_Missense_Mutation_p.H410Y	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	410	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CCTGCTGTCTCACCCCAGTGA	0.612													0	0	0	1	0	66	120										T	55107923	C	T	55107923	3	4	68	1	0	0	0	0	1	0	0	0	8784	826	29	1	1250	1	LILRA1	19	55107923	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	29	55107923	4021060	938	21458										
NLRP2	55655	broad.mit.edu	37	chr19	55493683	55493683	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggtgcttcccgggcccttctCatacacggtggtgctgtatg	13	12	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:55493683C>T	uc002qij.2	+	6	703	c.617C>T	c.(616-618)TCA>TTA	p.S206L	NLRP2_uc010yfp.1_Missense_Mutation_p.S183L|NLRP2_uc010esn.2_Missense_Mutation_p.S182L|NLRP2_uc010eso.2_Missense_Mutation_p.S203L|NLRP2_uc010esp.2_Missense_Mutation_p.S184L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	206					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGGCCCTTCTCATACACGGTG	0.542													0	0	0	1	0	24	94										T	55493683	C	T	55493683	3	4	68	1	0	0	0	0	1	0	0	0	10477	838	29	1	635	1	NLRP2	19	55493683	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	385760	55493683	3635300	939	21459										
NLRP2	55655	broad.mit.edu	37	chr19	55502018	55502018	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgagggcttgaggtaccccGagtgtaaactgcagaccttg	14	9	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:55502018G>A	uc002qij.2	+	10	2772	c.2686G>A	c.(2686-2688)GAG>AAG	p.E896K	NLRP2_uc010yfp.1_Missense_Mutation_p.E873K|NLRP2_uc010esn.2_Missense_Mutation_p.E872K|NLRP2_uc010eso.2_Missense_Mutation_p.E893K|NLRP2_uc010esp.2_Missense_Mutation_p.E874K	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	896					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GAGGTACCCCGAGTGTAAACT	0.567													0	0	0	1	0	14	64										A	55502018	G	A	55502018	3	1	68	1	0	0	0	0	1	0	0	0	10477	1059	37	1	2720	1	NLRP2	19	55502018	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8335	55502018	3626965	940	21460										
NLRP11	204801	broad.mit.edu	37	chr19	56321174	56321174	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaggaaccagcagcctggagCcatttttctcttcagcaaac	9	12	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:56321174C>T	uc010ygf.1	-	5	1513	c.802G>A	c.(802-804)GCT>ACT	p.A268T	NLRP11_uc002qlz.2_Missense_Mutation_p.A169T|NLRP11_uc002qmb.2_Missense_Mutation_p.A169T|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	268	NACHT.						ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CAGCCTGGAGCCATTTTTCTC	0.458													0	0	0	1	0	11	53										T	56321174	C	T	56321174	3	4	68	1	0	0	0	0	1	0	0	0	10473	739	26	2	2331	2	NLRP11	19	56321174	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	819156	56321174	2807809	941	21461										
ZNF329	79673	broad.mit.edu	37	chr19	58639517	58639517	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attacactcatagggcttctCaccagtatgagtcctctggt	8	11	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:58639517C>T	uc002qrn.2	-	4	1591	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TAGGGCTTCTCACCAGTATGA	0.502													0	0	0	1	0	9	65										T	58639517	C	T	58639517	3	4	68	1	0	0	0	0	1	0	0	0	17844	835	29	1	275	1	ZNF329	19	58639517	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2318343	58639517	489466	942	21462										
ZNF132	7691	broad.mit.edu	37	chr19	58948469	58948469	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acactgtggtacaggtgcctCtgggctgcatcaaggagctc	13	11	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr19:58948469C>G	uc002qst.3	-	2	578	c.177G>C	c.(175-177)CAG>CAC	p.Q59H		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	59	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		ACAGGTGCCTCTGGGCTGCAT	0.517													0	0	0	1	0	13	60										G	58948469	C	G	58948469	3	3	68	1	0	0	0	0	1	0	0	0	17719	912	32	1	1951	1	ZNF132	19	58948469	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	308952	58948469	180514	943	21463										
JAG1	182	broad.mit.edu	37	chr20	10653409	10653409	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcgttgccgcggctggccttGaggttgaaggtgttgccccc	15	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:10653409G>A	uc002wnw.2	-	2	843	c.327C>T	c.(325-327)CTC>CTT	p.L109L		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	109	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GGCTGGCCTTGAGGTTGAAGG	0.662									Alagille_Syndrome				0	0	0	1	0	11	20										A	10653409	G	A	10653409	2	1	68	1	0	0	0	0	0	0	0	1	7934	1277	45	1		1	JAG1	20	10653409	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08		10653409	52372111	944	21464										
RBBP9	10741	broad.mit.edu	37	chr20	18477724	18477724	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcgcttaccttctccagctCctttttcacccagccatacc	5	18	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:18477724C>T	uc002wqy.2	-	1	164	c.88G>A	c.(88-90)GAG>AAG	p.E30K		NM_006606	NP_006597	O75884	RBBP9_HUMAN	retinoblastoma binding protein 9	30						cytoplasm|nucleus	hydrolase activity			haematopoietic_and_lymphoid_tissue(1)	1						TTCTCCAGCTCCTTTTTCACC	0.612													0	0	0	1	0	4	32										T	18477724	C	T	18477724	3	4	68	1	0	0	0	0	1	0	0	0	13106	864	30	1	492	1	RBBP9	20	18477724	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	7824315	18477724	44547796	945	21465										
C20orf26	26074	broad.mit.edu	37	chr20	20177348	20177348	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cactacaccaagttctttctGaaggagatcctgcgtttagg	9	10	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:20177348G>T	uc002wru.2	+	16	1801	c.1725G>T	c.(1723-1725)CTG>CTT	p.L575L	C20orf26_uc010zse.1_Silent_p.L555L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	575										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		AGTTCTTTCTGAAGGAGATCC	0.468													1	0	2.79863e-10	1	3.10412e-10	27	47										T	20177348	G	T	20177348	2	4	68	1	0	0	0	0	0	0	0	1	2106	1277	45	3		3	C20orf26	20	20177348	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1699624	20177348	42848172	946	21466										
ASXL1	171023	broad.mit.edu	37	chr20	31021535	31021535	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acagaattcctagcctgcctCaggaaactgtggatcaggaa	10	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:31021535C>T	uc002wxs.2	+	11	1960	c.1534C>T	c.(1534-1536)CAG>TAG	p.Q512*	ASXL1_uc010geb.2_Nonsense_Mutation_p.Q403*	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	512					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TAGCCTGCCTCAGGAAACTGT	0.547			F|N|Mis		MDS|CMML								0	0	0	1	0	34	167										T	31021535	C	T	31021535	4	4	68	1	0	0	0	0	0	1	0	0	1066	827	29	1	1586	1	ASXL1	20	31021535	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10844187	31021535	32003985	947	21467										
ASXL1	171023	broad.mit.edu	37	chr20	31023784	31023784	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagtactgagtaccagccaaGagccgtgtgcctgtccatgc	11	13	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:31023784G>C	uc002wxs.2	+	12	3695	c.3269G>C	c.(3268-3270)AGA>ACA	p.R1090T	ASXL1_uc010geb.2_Missense_Mutation_p.R981T	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1090					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TACCAGCCAAGAGCCGTGTGC	0.572			F|N|Mis		MDS|CMML								0	0	0	1	0	20	73										C	31023784	G	C	31023784	3	2	68	1	0	0	0	0	1	0	0	0	1066	942	33	1	3325	1	ASXL1	20	31023784	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2249	31023784	32001736	948	21468										
GSS	2937	broad.mit.edu	37	chr20	33530781	33530781	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttgtggatgtcaaagagacGagcggtaaagtcatcctgtt	12	7	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:33530781G>A	uc002xbg.2	-	4	384	c.304C>T	c.(304-306)CGT>TGT	p.R102C	GSS_uc010zun.1_5'UTR|GSS_uc010zuo.1_Intron|GSS_uc010zup.1_Missense_Mutation_p.R33C|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	102					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	TCAAAGAGACGAGCGGTAAAG	0.478													0	0	0	1	0	5	9										A	33530781	G	A	33530781	3	1	68	1	0	0	0	0	1	0	0	0	6829	1058	37	1	1160	1	GSS	20	33530781	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2506997	33530781	29494739	949	21469										
KIAA0406	9675	broad.mit.edu	37	chr20	36634718	36634718	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttctcaagagctgctggtCtttggttcaaatgacttccc	8	11	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:36634718C>G	uc002xhl.2	-	4	2593	c.2384G>C	c.(2383-2385)AGA>ACA	p.R795T	KIAA0406_uc002xhm.2_Missense_Mutation_p.R795T	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	795							binding				0		Myeloproliferative disorder(115;0.00874)				AGCTGCTGGTCTTTGGTTCAA	0.463													0	0	0	1	0	52	73										G	36634718	C	G	36634718	3	3	68	1	0	0	0	0	1	0	0	0	8173	913	32	1	909	1	KIAA0406	20	36634718	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3103937	36634718	26390802	950	21470										
ZHX3	23051	broad.mit.edu	37	chr20	39832521	39832521	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gaaccagatcttgagctgttCttctggatacttggtcacca	9	10	4	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:39832521C>A	uc002xjs.1	-	3	1414	c.1036G>T	c.(1036-1038)GAA>TAA	p.E346*	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Nonsense_Mutation_p.E346*|ZHX3_uc002xjt.1_Nonsense_Mutation_p.E346*|ZHX3_uc002xju.1_Nonsense_Mutation_p.E346*|ZHX3_uc002xjv.1_Nonsense_Mutation_p.E346*|ZHX3_uc002xjw.1_Nonsense_Mutation_p.E346*|ZHX3_uc010ggg.1_Nonsense_Mutation_p.E346*	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	346	Homeobox 1.|Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				TTGAGCTGTTCTTCTGGATAC	0.507													1	0	3.08376e-08	1	3.34384e-08	25	42										A	39832521	C	A	39832521	4	1	68	1	0	0	0	0	0	1	0	0	17674	922	32	3	1842	3	ZHX3	20	39832521	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3197803	39832521	23192999	951	21471										
EMILIN3	90187	broad.mit.edu	37	chr20	39990162	39990162	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaagtgtcccactgtgtgctGaagtttctgggctgtgtcct	12	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:39990162G>C	uc002xjy.1	-	4	2271	c.2047C>G	c.(2047-2049)CAG>GAG	p.Q683E		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	683						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				ACTGTGTGCTGAAGTTTCTGG	0.657													0	0	0	1	0	5	24										C	39990162	G	C	39990162	3	2	68	1	0	0	0	0	1	0	0	0	5095	1299	45	1	257	1	EMILIN3	20	39990162	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	157641	39990162	23035358	952	21472										
PLTP	5360	broad.mit.edu	37	chr20	44538206	44538206	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tggagacagaggcctggcagGagacattggacactttcatc	13	9	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:44538206G>A	uc002xqn.1	-	5	514	c.434C>T	c.(433-435)TCC>TTC	p.S145F	PLTP_uc002xql.1_Missense_Mutation_p.S57F|PLTP_uc002xqm.1_Missense_Mutation_p.S165F|PLTP_uc002xqo.1_Intron|PLTP_uc002xqp.1_Missense_Mutation_p.S145F|PLTP_uc002xqq.1_Missense_Mutation_p.S114F|PLTP_uc010zxj.1_Intron|PLTP_uc010ghj.1_Missense_Mutation_p.S145F	NM_006227	NP_006218	P55058	PLTP_HUMAN	phospholipid transfer protein isoform a	145					cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGCCTGGCAGGAGACATTGGA	0.622													0	0	0	1	0	17	130										A	44538206	G	A	44538206	3	1	68	1	0	0	0	0	1	0	0	0	12114	1174	41	1	1095	1	PLTP	20	44538206	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	4548044	44538206	18487314	953	21473										
PCIF1	63935	broad.mit.edu	37	chr20	44567904	44567904	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gctggagccggagggagaatCgtccctactacttcaaccga	12	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:44567904C>T	uc002xqs.2	+	4	489	c.175C>T	c.(175-177)CGT>TGT	p.R59C		NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	59	WW.					nucleus				skin(1)	1						GAGGGAGAATCGTCCCTACTA	0.632													0	0	0	1	0	16	91										T	44567904	C	T	44567904	3	4	68	1	0	0	0	0	1	0	0	0	11580	884	31	1	181	1	PCIF1	20	44567904	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	29698	44567904	18457616	954	21474										
ZNF335	63925	broad.mit.edu	37	chr20	44578480	44578480	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgctgtacggtctggccatCtgccgtggtgatctcttgga	14	10	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:44578480C>T	uc002xqw.2	-	24	3751	c.3628G>A	c.(3628-3630)GAT>AAT	p.D1210N	ZNF335_uc002xqv.2_Missense_Mutation_p.D322N|ZNF335_uc010zxk.1_Missense_Mutation_p.D1055N	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1210	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				GTCTGGCCATCTGCCGTGGTG	0.582													0	0	0	1	0	16	99										T	44578480	C	T	44578480	3	4	68	1	0	0	0	0	1	0	0	0	17849	913	32	1	420	1	ZNF335	20	44578480	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	10576	44578480	18447040	955	21475										
SLC13A3	64849	broad.mit.edu	37	chr20	45192108	45192108	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgatggagttggggggcgttGagaccgggagcatgaaggca	20	6	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:45192108G>T	uc002xsf.1	-	12	1615	c.1577C>A	c.(1576-1578)TCA>TAA	p.S526*	SLC13A3_uc010ghn.1_Nonsense_Mutation_p.S495*|SLC13A3_uc010zxw.1_Nonsense_Mutation_p.S476*|SLC13A3_uc002xsg.1_Nonsense_Mutation_p.S479*|SLC13A3_uc010gho.1_Nonsense_Mutation_p.S444*|SLC13A3_uc010zxx.1_Nonsense_Mutation_p.S428*|SLC13A3_uc002xse.1_Nonsense_Mutation_p.S17*|SLC13A3_uc010ghm.1_Nonsense_Mutation_p.S113*|SLC13A3_uc010zxv.1_Nonsense_Mutation_p.S111*	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	526	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	GGGGGGCGTTGAGACCGGGAG	0.617													1	0	1.5842e-08	1	1.72077e-08	13	23										T	45192108	G	T	45192108	4	4	68	1	0	0	0	0	0	1	0	0	14393	1294	45	3	239	3	SLC13A3	20	45192108	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	613628	45192108	17833412	956	21476										
NCOA3	8202	broad.mit.edu	37	chr20	46267858	46267858	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtcctccagtaaaaaatatCagtgctttccccatgttacc	5	12	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:46267858C>G	uc002xtk.2	+	14	2824	c.2619C>G	c.(2617-2619)ATC>ATG	p.I873M	NCOA3_uc010ght.1_Missense_Mutation_p.I883M|NCOA3_uc002xtl.2_Missense_Mutation_p.I873M|NCOA3_uc002xtm.2_Missense_Mutation_p.I873M|NCOA3_uc002xtn.2_Missense_Mutation_p.I873M|NCOA3_uc010zyc.1_Missense_Mutation_p.I668M	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	873					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TAAAAAATATCAGTGCTTTCC	0.438													0	0	0	1	0	22	69										G	46267858	C	G	46267858	3	3	68	1	0	0	0	0	1	0	0	0	10230	816	29	1	2695	1	NCOA3	20	46267858	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1075750	46267858	16757662	957	21477										
DDX27	55661	broad.mit.edu	37	chr20	47859135	47859135	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttctctctgtgcacagccaaGaagcaaaagcaggggaagaa	11	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:47859135G>C	uc002xuh.2	+	19	2275	c.2214G>C	c.(2212-2214)AAG>AAC	p.K738N		NM_017895	NP_060365	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	738						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			kidney(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCACAGCCAAGAAGCAAAAGC	0.433													0	0	0	1	0	21	125										C	47859135	G	C	47859135	3	2	68	1	0	0	0	0	1	0	0	0	4354	933	33	1	2288	1	DDX27	20	47859135	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1591277	47859135	15166385	958	21478										
ZNFX1	57169	broad.mit.edu	37	chr20	47888002	47888002	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgtcattggaccatggtggtCtgcggttcctacagtcctgg	13	10	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:47888002C>G	uc002xui.2	-	3	594	c.347G>C	c.(346-348)AGA>ACA	p.R116T		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	116							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CCATGGTGGTCTGCGGTTCCT	0.547													0	0	0	1	0	60	243										G	47888002	C	G	47888002	3	3	68	1	0	0	0	0	1	0	0	0	18202	913	32	1	5457	1	ZNFX1	20	47888002	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	28867	47888002	15137518	959	21479										
TMEM189-UBE2V1	387522	broad.mit.edu	37	chr20	48699389	48699389	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggcgccgaagctcttgcagGacaactttgatgctatatga	11	9	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:48699389G>A	uc002xvf.2	-	8	1190	c.1029C>T	c.(1027-1029)GTC>GTT	p.V343V	UBE2V1_uc002xvb.2_RNA|UBE2V1_uc002xva.2_Silent_p.V120V|UBE2V1_uc002xvc.2_Silent_p.V76V|UBE2V1_uc002xvd.2_Silent_p.V143V|UBE2V1_uc002xve.2_Silent_p.V143V	NM_199203	NP_954673	Q13404	UB2V1_HUMAN	TMEM189-UBE2V1 readthrough transcript	120					cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein K63-linked ubiquitination|regulation of DNA repair|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-UEV1A complex|ubiquitin ligase complex	acid-amino acid ligase activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(9;8.29e-07)			GCTCTTGCAGGACAACTTTGA	0.418													0	0	0	1	0	18	73										A	48699389	G	A	48699389	2	1	68	1	0	0	0	0	0	0	0	1	16109	1161	41	1		1	TMEM189-UBE2V1	20	48699389	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	811387	48699389	14326131	960	21480										
MC3R	4159	broad.mit.edu	37	chr20	54824451	54824451	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgttcatcgtctactcggaGagcaaaatggtcattgtgtg	12	7	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:54824451G>C	uc002xxb.2	+	1	664	c.552G>C	c.(550-552)GAG>GAC	p.E184D		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	221	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			TCTACTCGGAGAGCAAAATGG	0.572													0	0	0	1	0	11	91										C	54824451	G	C	54824451	3	2	68	1	0	0	0	0	1	0	0	0	9365	933	33	1	554	1	MC3R	20	54824451	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6125062	54824451	8201069	961	21481										
GNAS	2778	broad.mit.edu	37	chr20	57484238	57484238	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcctggacaagatcgacgtGatcaagcaggctgactatgt	11	9	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:57484238G>A	uc002xzw.2	+	7	2766	c.2481G>A	c.(2479-2481)GTG>GTA	p.V827V	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Silent_p.V125V|GNAS_uc002xzx.2_Silent_p.V125V|GNAS_uc010gjr.2_Silent_p.V75V|GNAS_uc002xzy.2_Silent_p.V110V|GNAS_uc002yaa.2_Silent_p.V170V|GNAS_uc010zzt.1_Silent_p.V185V|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Silent_p.V75V|GNAS_uc002yae.2_Silent_p.V109V	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	184					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AGATCGACGTGATCAAGCAGG	0.507			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	1	0	58	249										A	57484238	G	A	57484238	2	1	68	1	0	0	0	0	0	0	0	1	6510	1277	45	1		1	GNAS	20	57484238	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2659787	57484238	5541282	962	21482										
TAF4	6874	broad.mit.edu	37	chr20	60575275	60575275	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgtgatacataacttactaCatctggatgtaattccgtta	6	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:60575275C>A	uc002ybs.2	-	11	2692	c.2692G>T	c.(2692-2694)GTA>TTA	p.V898L		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	898					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TAACTTACTACATCTGGATGT	0.348													1	0	6.42651e-13	1	7.25574e-13	11	95										A	60575275	C	A	60575275	3	1	68	1	0	0	0	0	1	0	0	0	15523	478	17	4	585	4	TAF4	20	60575275	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3091037	60575275	2450245	963	21483										
DIDO1	11083	broad.mit.edu	37	chr20	61512984	61512984	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	catcctgttgggcaggtcatCaacagtcactttcgcttctt	8	12	4	0	rs142722598		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:61512984C>G	uc002ydr.1	-	16	4588	c.4324G>C	c.(4324-4326)GAT>CAT	p.D1442H	DIDO1_uc002yds.1_Missense_Mutation_p.D1442H	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1442					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GGCAGGTCATCAACAGTCACT	0.627													0	0	0	1	0	46	92										G	61512984	C	G	61512984	3	3	68	1	0	0	0	0	1	0	0	0	4522	826	29	1	2402	1	DIDO1	20	61512984	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	937709	61512984	1512536	964	21484										
COL20A1	57642	broad.mit.edu	37	chr20	61936863	61936863	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggctacaccttgcagatcttCgagctcactggctctgggcg	12	13	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:61936863C>T	uc011aau.1	+	4	388	c.288C>T	c.(286-288)TTC>TTT	p.F96F	COL20A1_uc011aav.1_5'Flank	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	96	Fibronectin type-III 1.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGCAGATCTTCGAGCTCACTG	0.627													0	0	0	1	0	7	7										T	61936863	C	T	61936863	2	4	68	1	0	0	0	0	0	0	0	1	3679	883	31	1		1	COL20A1	20	61936863	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	423879	61936863	1088657	965	21485										
PRIC285	85441	broad.mit.edu	37	chr20	62200734	62200734	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tccatctcctcagggtggccGagcgccagattcctgcaggg	13	14	2	1	rs147054984		TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:62200734G>A	uc002yfm.2	-	5	1747	c.855C>T	c.(853-855)CTC>CTT	p.L285L	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	285					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CAGGGTGGCCGAGCGCCAGAT	0.692													0	0	0	1	0	5	14										A	62200734	G	A	62200734	2	1	68	1	0	0	0	0	0	0	0	1	12485	1045	37	1		1	PRIC285	20	62200734	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	263871	62200734	824786	966	21486										
TCEA2	6919	broad.mit.edu	37	chr20	62701842	62701842	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccactggccccgtgctccagGagatggccagtgatgagctg	14	13	0	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr20:62701842G>C	uc011abs.1	+	8	1329	c.673G>C	c.(673-675)GAG>CAG	p.E225Q	TCEA2_uc011abr.1_Missense_Mutation_p.E198Q|TCEA2_uc010gks.2_Missense_Mutation_p.E226Q	NM_003195	NP_003186	Q15560	TCEA2_HUMAN	transcription elongation factor A protein 2	225	TFIIS central.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	transcription elongation factor complex	DNA binding|protein binding|translation elongation factor activity|zinc ion binding				0	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					CGTGCTCCAGGAGATGGCCAG	0.642													0	0	0	1	0	18	31										C	62701842	G	C	62701842	3	2	68	1	0	0	0	0	1	0	0	0	15665	1188	41	1	703	1	TCEA2	20	62701842	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	501108	62701842	323678	967	21487										
SOD1	6647	broad.mit.edu	37	chr21	33039654	33039654	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agattctgtgatctcactctCaggagaccattgcatcattg	8	10	4	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr21:33039654C>G	uc002ypa.2	+	4	471	c.323C>G	c.(322-324)TCA>TGA	p.S108*	SOD1_uc002ypb.2_Nonsense_Mutation_p.S89*|SOD1_uc002ypc.2_RNA	NM_000454	NP_000445	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	108					activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding				0						ATCTCACTCTCAGGAGACCAT	0.403													0	0	0	1	0	9	81										G	33039654	C	G	33039654	4	3	68	1	0	0	0	0	0	1	0	0	14920	838	29	1	337	1	SOD1	21	33039654	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		33039654	15090241	968	21488										
DSCAM	1826	broad.mit.edu	37	chr21	41496164	41496164	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aatacagtgtactttcggatGatgccgttcagcttgagagg	12	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr21:41496164G>A	uc002yyq.1	-	20	4106	c.3654C>T	c.(3652-3654)ATC>ATT	p.I1218I	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1218	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ACTTTCGGATGATGCCGTTCA	0.572													0	0	0	1	0	34	110										A	41496164	G	A	41496164	2	1	68	1	0	0	0	0	0	0	0	1	4768	1280	45	1		1	DSCAM	21	41496164	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	8456510	41496164	6633731	969	21489										
RRP1B	23076	broad.mit.edu	37	chr21	45107624	45107624	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ccacgtccagcactggggagGagagtggctccgagcatcct	14	13	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr21:45107624G>T	uc002zdk.2	+	13	1483	c.1369G>T	c.(1369-1371)GAG>TAG	p.E457*	RRP1B_uc002zdl.2_5'UTR	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	457					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		CACTGGGGAGGAGAGTGGCTC	0.637													1	0	3.41278e-10	1	3.78198e-10	18	41										T	45107624	G	T	45107624	4	4	68	1	0	0	0	0	0	1	0	0	13688	1175	41	3	1419	3	RRP1B	21	45107624	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3611460	45107624	3022271	970	21490										
ADARB1	104	broad.mit.edu	37	chr21	46603308	46603308	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcaaaaaagatccatctttCagaaatcagagcgagggggg	11	7	4	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr21:46603308C>G	uc002zgy.2	+	7	1714	c.1279C>G	c.(1279-1281)CAG>GAG	p.Q427E	ADARB1_uc002zgr.2_Missense_Mutation_p.Q427E|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Missense_Mutation_p.Q427E|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Missense_Mutation_p.Q427E|ADARB1_uc010gpx.2_RNA|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	427	A to I editase.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		ATCCATCTTTCAGAAATCAGA	0.378													0	0	0	1	0	5	33										G	46603308	C	G	46603308	3	3	68	1	0	0	0	0	1	0	0	0	282	827	29	1	1297	1	ADARB1	21	46603308	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1495684	46603308	1526587	971	21491										
MCM3AP	8888	broad.mit.edu	37	chr21	47663416	47663416	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cgggggggcgtccagtctctCagcttgtggttgatacacaa	14	10	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr21:47663416C>T	uc002zir.1	-	24	5295	c.5259G>A	c.(5257-5259)CTG>CTA	p.L1753L	MCM3APAS_uc002zim.2_Intron|MCM3APAS_uc002zin.2_Intron|MCM3AP_uc002zio.1_Silent_p.L248L|MCM3AP_uc002zip.1_Silent_p.L494L|MCM3AP_uc002ziq.1_Silent_p.L680L|MCM3APAS_uc002zis.1_Intron	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1753					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					TCCAGTCTCTCAGCTTGTGGT	0.552													0	0	0	1	0	31	153										T	47663416	C	T	47663416	2	4	68	1	0	0	0	0	0	0	0	1	9388	813	29	1		1	MCM3AP	21	47663416	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1060108	47663416	466479	972	21492										
CDC45	8318	broad.mit.edu	37	chr22	19506422	19506422	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggacgcacttatttccctCctgtcctagggtgagttaca	9	12	0	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:19506422C>A	uc002zpr.2	+	18	1768	c.1692C>A	c.(1690-1692)CTC>CTA	p.L564L	CDC45_uc011aha.1_Silent_p.L596L|CDC45_uc002zps.2_Silent_p.L565L|CDC45_uc002zpt.2_Silent_p.L518L	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	564					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						TTATTTCCCTCCTGTCCTAGG	0.557													1	0	1.55469e-16	1	1.77277e-16	22	66										A	19506422	C	A	19506422	2	1	68	1	0	0	0	0	0	0	0	1	3081	842	30	3		3	CDC45	22	19506422	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		19506422	31798144	973	21493										
SEPT5	5413	broad.mit.edu	37	chr22	19709228	19709228	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccaaggggcagcgggtccgGggccgactgtacccctgggg	19	13	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:19709228G>T	uc002zpv.1	+	9	908	c.783G>T	c.(781-783)CGG>CGT	p.R261R	SEPT5_uc002zpw.1_RNA|SEPT5_uc002zpx.1_RNA|SEPT5_uc002zpy.1_5'UTR|SEPT5_uc002zpz.1_5'Flank	NM_002688	NP_002679	Q99719	SEPT5_HUMAN	septin 5	261					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)	1	Colorectal(54;0.0993)					AGCGGGTCCGGGGCCGACTGT	0.682													1	0	4.7546e-09	1	5.20035e-09	16	40										T	19709228	G	T	19709228	2	4	68	1	0	0	0	0	0	0	0	1	14067	1219	43	4		4	SEPT5	22	19709228	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	202806	19709228	31595338	974	21494										
C22orf29	79680	broad.mit.edu	37	chr22	19839388	19839388	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gacacggctgatgttgtcctGatagtgctcaaagtggaagg	14	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:19839388G>A	uc002zqg.2	-	2	996	c.397C>T	c.(397-399)CAG>TAG	p.Q133*	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Nonsense_Mutation_p.Q133*|C22orf29_uc002zqi.2_Nonsense_Mutation_p.Q133*|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	133											0	Colorectal(54;0.0993)					ATGTTGTCCTGATAGTGCTCA	0.622													0	0	0	1	0	18	88										A	19839388	G	A	19839388	4	1	68	1	0	0	0	0	0	1	0	0	2141	1299	45	1	701	1	C22orf29	22	19839388	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	130160	19839388	31465178	975	21495										
GGT1	2678	broad.mit.edu	37	chr22	25016336	25016336	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctggggagatccgaggctatGagctggcacaccagcggcat	15	11	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:25016336G>T	uc003aan.1	+	8	911	c.424G>T	c.(424-426)GAG>TAG	p.E142*	GGT1_uc003aas.1_Nonsense_Mutation_p.E142*|GGT1_uc003aat.1_Nonsense_Mutation_p.E142*|GGT1_uc003aau.1_Nonsense_Mutation_p.E142*|GGT1_uc003aav.1_Nonsense_Mutation_p.E142*|GGT1_uc003aaw.1_Nonsense_Mutation_p.E142*|GGT1_uc003aax.1_Nonsense_Mutation_p.E142*	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	142	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	CCGAGGCTATGAGCTGGCACA	0.687													1	0	0.000602214	1	0.000619927	5	26										T	25016336	G	T	25016336	4	4	68	1	0	0	0	0	0	1	0	0	6361	1291	45	3	438	3	GGT1	22	25016336	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5176948	25016336	26288230	976	21496										
SGSM1	129049	broad.mit.edu	37	chr22	25297899	25297899	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acttcacgcccgccaacttgGagaagctgcgtaacatcatg	9	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:25297899G>A	uc003abg.2	+	21	3032	c.2875G>A	c.(2875-2877)GAG>AAG	p.E959K	SGSM1_uc003abh.2_Missense_Mutation_p.E898K|SGSM1_uc010guu.1_Missense_Mutation_p.E904K|SGSM1_uc003abj.2_Missense_Mutation_p.E843K|SGSM1_uc003abi.1_Missense_Mutation_p.E879K	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	959	Rab-GAP TBC.					Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						CGCCAACTTGGAGAAGCTGCG	0.622													0	0	0	1	0	9	4										A	25297899	G	A	25297899	3	1	68	1	0	0	0	0	1	0	0	0	14222	1175	41	1	2957	1	SGSM1	22	25297899	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	281563	25297899	26006667	977	21497										
SF3A1	10291	broad.mit.edu	37	chr22	30733035	30733035	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttgtttctgcgcaggaactCctcctctggcatgaggctgt	11	12	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:30733035C>A	uc003ahl.2	-	13	2218	c.2086G>T	c.(2086-2088)GAG>TAG	p.E696*		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	696					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						CGCAGGAACTCCTCCTCTGGC	0.557													1	0	4.87955e-14	1	5.52899e-14	24	70										A	30733035	C	A	30733035	4	1	68	1	0	0	0	0	0	1	0	0	14146	864	30	3	311	3	SF3A1	22	30733035	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5435136	30733035	20571531	978	21498										
PATZ1	23598	broad.mit.edu	37	chr22	31722980	31722980	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acccaaaggactcgaggagaGacatgttctgctgaggagag	14	8	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:31722980G>T	uc003akq.2	-	5	2622	c.1961C>A	c.(1960-1962)TCT>TAT	p.S654Y	PATZ1_uc003akp.2_3'UTR|PATZ1_uc003akr.2_Missense_Mutation_p.S608Y	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	654					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CTCGAGGAGAGACATGTTCTG	0.567													1	0	2.27731e-05	1	2.38323e-05	21	79										T	31722980	G	T	31722980	3	4	68	1	0	0	0	0	1	0	0	0	11476	942	33	3	106	3	PATZ1	22	31722980	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	989945	31722980	19581586	979	21499										
C22orf24	25775	broad.mit.edu	37	chr22	32334043	32334043	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cagccctgttgtatcctcttGagttgtcatgacattgtctg	9	10	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:32334043G>C	uc003aly.2	-	2	177	c.10C>G	c.(10-12)CAA>GAA	p.Q4E	C22orf24_uc003alx.2_RNA	NM_015372	NP_056187	Q9Y442	CV024_HUMAN	hypothetical protein LOC25775	4						integral to membrane				central_nervous_system(1)	1						GTATCCTCTTGAGTTGTCATG	0.328													0	0	0	1	0	47	194										C	32334043	G	C	32334043	3	2	68	1	0	0	0	0	1	0	0	0	2138	1299	45	1	480	1	C22orf24	22	32334043	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	611063	32334043	18970523	980	21500										
APOL5	80831	broad.mit.edu	37	chr22	36123215	36123215	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcccggggcagggctgttcGaggatcccgtgtggttaaac	15	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:36123215G>C	uc003aof.2	+	3	1100	c.1100G>C	c.(1099-1101)CGA>CCA	p.R367P		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	367					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						AGGGCTGTTCGAGGATCCCGT	0.607													0	0	0	1	0	9	52										C	36123215	G	C	36123215	3	2	68	1	0	0	0	0	1	0	0	0	809	1058	37	1	1110	1	APOL5	22	36123215	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3789172	36123215	15181351	981	21501										
MYH9	4627	broad.mit.edu	37	chr22	36684830	36684830	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcgtcccggccctgcaggtcCcgctcgaactgggccttcat	11	17	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:36684830C>A	uc003apg.2	-	33	4944	c.4713G>T	c.(4711-4713)CGG>CGT	p.R1571R		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1571	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCTGCAGGTCCCGCTCGAACT	0.642			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				1	0	2.27731e-05	1	2.38323e-05	22	139										A	36684830	C	A	36684830	2	1	68	1	0	0	0	0	0	0	0	1	10042	610	22	4		4	MYH9	22	36684830	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	561615	36684830	14619736	982	21502										
FOXRED2	80020	broad.mit.edu	37	chr22	36894043	36894043	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggacgggctactcactccttCaacaggatgacatcggccag	11	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:36894043C>T	uc003apn.3	-	5	1485	c.1377G>A	c.(1375-1377)TTG>TTA	p.L459L	FOXRED2_uc003apm.3_Silent_p.L11L|FOXRED2_uc003apo.3_Silent_p.L459L|FOXRED2_uc003app.3_Silent_p.L459L	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	459					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						CTCACTCCTTCAACAGGATGA	0.602													0	0	0	1	0	19	53										T	36894043	C	T	36894043	2	4	68	1	0	0	0	0	0	0	0	1	6034	825	29	1		1	FOXRED2	22	36894043	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	209213	36894043	14410523	983	21503										
MICALL1	85377	broad.mit.edu	37	chr22	38323565	38323565	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agctgtgcccaagagctcctCagagcctgctgtccatgccc	10	16	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:38323565C>G	uc003aui.2	+	9	1697	c.1613C>G	c.(1612-1614)TCA>TGA	p.S538*		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	538	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					AAGAGCTCCTCAGAGCCTGCT	0.637													0	0	0	1	0	14	69										G	38323565	C	G	38323565	4	3	68	1	0	0	0	0	0	1	0	0	9573	838	29	1	1647	1	MICALL1	22	38323565	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1429522	38323565	12981001	984	21504										
MICALL1	85377	broad.mit.edu	37	chr22	38323678	38323678	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctagagtggaacaaatgcctCaagccagccctggccttgcc	10	14	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:38323678C>G	uc003aui.2	+	9	1810	c.1726C>G	c.(1726-1728)CAA>GAA	p.Q576E		NM_033386	NP_203744	Q8N3F8	MILK1_HUMAN	molecule interacting with Rab13	576	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)	1	Melanoma(58;0.045)					ACAAATGCCTCAAGCCAGCCC	0.642													0	0	0	1	0	24	130										G	38323678	C	G	38323678	3	3	68	1	0	0	0	0	1	0	0	0	9573	827	29	1	1760	1	MICALL1	22	38323678	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	113	38323678	12980888	985	21505										
APOBEC3D	140564	broad.mit.edu	37	chr22	39425374	39425374	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tcttgtgccctcagaaacccGatggaggcaatgtacccaca	9	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:39425374G>A	uc011aoe.1	+	5	666	c.612G>A	c.(610-612)CCG>CCA	p.P204P	APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Silent_p.P204P|APOBEC3D_uc010gxu.2_5'UTR	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	204					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					TCAGAAACCCGATGGAGGCAA	0.522													0	0	0	1	0	23	51										A	39425374	G	A	39425374	2	1	68	1	0	0	0	0	0	0	0	1	792	1045	37	1		1	APOBEC3D	22	39425374	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1101696	39425374	11879192	986	21506										
APOBEC3G	60489	broad.mit.edu	37	chr22	39477087	39477087	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acaagggatatggccacgttCctggccgaggacccgaaggt	14	11	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:39477087C>T	uc003awx.2	+	3	663	c.321C>T	c.(319-321)TTC>TTT	p.F107F	APOBEC3G_uc003awy.2_Silent_p.F40F	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	107					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					TGGCCACGTTCCTGGCCGAGG	0.562													0	0	0	1	0	13	87										T	39477087	C	T	39477087	2	4	68	1	0	0	0	0	0	0	0	1	794	854	30	1		1	APOBEC3G	22	39477087	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	51713	39477087	11827479	987	21507										
RPL3	6122	broad.mit.edu	37	chr22	39710727	39710727	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtgcggtgatggtagcctttCtgcccagcgcgtgccacaga	14	12	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:39710727C>T	uc003axi.2	-	6	881	c.813G>A	c.(811-813)CAG>CAA	p.Q271Q	RPL3_uc003axh.2_Silent_p.Q222Q|RPL3_uc003axj.2_Silent_p.Q119Q|RPL3_uc010gxx.2_Silent_p.Q219Q|RPL3_uc003axg.2_Silent_p.Q219Q|RPL3_uc003axk.1_Silent_p.Q119Q	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	271					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					GGTAGCCTTTCTGCCCAGCGC	0.622													0	0	0	1	0	9	31										T	39710727	C	T	39710727	2	4	68	1	0	0	0	0	0	0	0	1	13579	912	32	1		1	RPL3	22	39710727	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	233640	39710727	11593839	988	21508										
CACNA1I	8911	broad.mit.edu	37	chr22	40058011	40058011	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tacgggccatggggccgcagCgcggcctgggccagccgtcg	18	15	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:40058011C>T	uc003ayc.2	+	17	2943	c.2943C>T	c.(2941-2943)AGC>AGT	p.S981S	CACNA1I_uc003ayd.2_Silent_p.S946S|CACNA1I_uc003aye.2_Silent_p.S896S|CACNA1I_uc003ayf.2_Silent_p.S861S	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	981	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGGGCCGCAGCGCGGCCTGGG	0.721													0	0	0	1	0	3	4										T	40058011	C	T	40058011	2	4	68	1	0	0	0	0	0	0	0	1	2546	767	27	2		2	CACNA1I	22	40058011	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	347284	40058011	11246555	989	21509										
WBP2NL	164684	broad.mit.edu	37	chr22	42422777	42422777	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttataattcccagttattgtCtatggagccccacctgcagg	8	11	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:42422777C>G	uc011ape.1	+	7	538	c.522C>G	c.(520-522)GTC>GTG	p.V174V	WBP2NL_uc003bbt.2_Silent_p.V174V|WBP2NL_uc011apk.1_Silent_p.V46V|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_RNA	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	174					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						CAGTTATTGTCTATGGAGCCC	0.468													0	0	0	1	0	51	85										G	42422777	C	G	42422777	2	3	68	1	0	0	0	0	0	0	0	1	17257	900	32	1		1	WBP2NL	22	42422777	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2364766	42422777	8881789	990	21510										
ARFGAP3	26286	broad.mit.edu	37	chr22	43230283	43230283	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agaggcaaaaaaatcttcctCctttggtggaggggacaaag	12	7	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:43230283C>A	uc003bdd.2	-	5	662	c.442G>T	c.(442-444)GAG>TAG	p.E148*	ARFGAP3_uc010gzf.2_Nonsense_Mutation_p.E104*|ARFGAP3_uc011apu.1_Intron	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	148					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						AAATCTTCCTCCTTTGGTGGA	0.423													1	0	6.00099e-30	1	6.94967e-30	70	110										A	43230283	C	A	43230283	4	1	68	1	0	0	0	0	0	1	0	0	851	864	30	3	1156	3	ARFGAP3	22	43230283	Nonsense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	807506	43230283	8074283	991	21511										
TTLL1	25809	broad.mit.edu	37	chr22	43447825	43447825	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acctcgatcagccagggcttCagcttgtcgtcgatgatgat	11	11	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:43447825C>T	uc003bdi.2	-	9	1201	c.960G>A	c.(958-960)CTG>CTA	p.L320L	TTLL1_uc010gzh.2_Intron|TTLL1_uc003bdj.2_Silent_p.L206L|TTLL1_uc003bdh.2_Silent_p.L282L	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	320	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		GCCAGGGCTTCAGCTTGTCGT	0.572													0	0	0	1	0	17	59										T	43447825	C	T	43447825	2	4	68	1	0	0	0	0	0	0	0	1	16719	813	29	1		1	TTLL1	22	43447825	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	217542	43447825	7856741	992	21512										
SMC1B	27127	broad.mit.edu	37	chr22	45785753	45785753	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtatttcttatgaataggatGacacaggtcaaatagtcttc	8	6	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:45785753G>A	uc003bgc.2	-	10	1622	c.1570C>T	c.(1570-1572)CAT>TAT	p.H524Y	SMC1B_uc003bgd.2_Missense_Mutation_p.H524Y|SMC1B_uc003bge.1_Missense_Mutation_p.H307Y	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	524	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TGAATAGGATGACACAGGTCA	0.338													0	0	0	1	0	36	73										A	45785753	G	A	45785753	3	1	68	1	0	0	0	0	1	0	0	0	14782	1290	45	1	2201	1	SMC1B	22	45785753	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	2337928	45785753	5518813	993	21513										
WNT7B	7477	broad.mit.edu	37	chr22	46327115	46327115	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gccgccccacttccagccctCggcttggttgtagtagccct	10	17	0	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:46327115C>T	uc003bgo.2	-	3	807	c.433G>A	c.(433-435)GAG>AAG	p.E145K	WNT7B_uc010haa.2_Missense_Mutation_p.E149K	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	145					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		TTCCAGCCCTCGGCTTGGTTG	0.687													0	0	0	1	0	15	69										T	46327115	C	T	46327115	3	4	68	1	0	0	0	0	1	0	0	0	17392	893	31	1	624	1	WNT7B	22	46327115	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	541362	46327115	4977451	994	21514										
PKDREJ	10343	broad.mit.edu	37	chr22	46655581	46655581	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actatcacatgcccccgaagAtgctggtccatttcatccct	6	15	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:46655581A>G	uc003bhh.2	-	1	3639	c.3639T>C	c.(3637-3639)CAT>CAC	p.H1213H		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1213	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GCCCCCGAAGATGCTGGTCCA	0.438													0	0	0	1	0	24	117										G	46655581	A	G	46655581	2	3	68	1	0	0	0	0	0	0	0	1	11970	330	12	5		5	PKDREJ	22	46655581	Silent	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	328466	46655581	4648985	995	21515										
PLXNB2	23654	broad.mit.edu	37	chr22	50719197	50719197	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atgaggaaagacttgctgttCagcaggttggagaactggta	14	5	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chr22:50719197C>T	uc003bkv.3	-	24	4075	c.3969G>A	c.(3967-3969)CTG>CTA	p.L1323L	PLXNB2_uc003bkt.1_Silent_p.L115L|PLXNB2_uc003bku.1_Silent_p.L308L	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1323	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACTTGCTGTTCAGCAGGTTGG	0.657													0	0	0	1	0	8	29										T	50719197	C	T	50719197	2	4	68	1	0	0	0	0	0	0	0	1	12124	813	29	1		1	PLXNB2	22	50719197	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	4063616	50719197	585369	996	21516										
ARSH	347527	broad.mit.edu	37	chrX	2942120	2942120	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaccacaccttggtgtacttCacctctgacaacgggggcca	9	14	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:2942120C>A	uc011mhj.1	+	6	960	c.960C>A	c.(958-960)TTC>TTA	p.F320L		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	320						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TGGTGTACTTCACCTCTGACA	0.577													1	0	7.03913e-09	1	7.6857e-09	11	48										A	2942120	C	A	2942120	3	1	68	1	0	0	0	0	1	0	0	0	993	825	29	3	982	3	ARSH	23	2942120	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08		2942120	152328440	997	21517										
ARSF	416	broad.mit.edu	37	chrX	3002382	3002382	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actatggcatgccgttcactCtcgttgacagctgctggccg	11	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:3002382C>G	uc004cre.1	+	6	726	c.505C>G	c.(505-507)CTC>GTC	p.L169V	ARSF_uc004crf.1_Missense_Mutation_p.L169V	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	169						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCCGTTCACTCTCGTTGACAG	0.527													0	0	0	1	0	52	90										G	3002382	C	G	3002382	3	3	68	1	0	0	0	0	1	0	0	0	991	913	32	1	523	1	ARSF	23	3002382	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	60262	3002382	152268178	998	21518										
PRKX	5613	broad.mit.edu	37	chrX	3530357	3530357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtcaccagctatcttgggcaCgatgggaggctgtgagacat	14	9	2	1	rs139150166	byFrequency	TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:3530357C>T	uc010nde.2	-	8	1328	c.961G>A	c.(961-963)GTG>ATG	p.V321M		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	321	AGC-kinase C-terminal.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)				ATCTTGGGCACGATGGGAGGC	0.537													0	0	0	1	0	5	31										T	3530357	C	T	3530357	3	4	68	1	0	0	0	0	1	0	0	0	12527	536	19	2	119	2	PRKX	23	3530357	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	527975	3530357	151740203	999	21519										
EGFL6	25975	broad.mit.edu	37	chrX	13635940	13635940	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttgctcacaaaaacagcatGaaaaagaaggcaaaaattaa	6	7	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:13635940G>T	uc004cvi.2	+	8	1110	c.870G>T	c.(868-870)ATG>ATT	p.M290I	EGFL6_uc004cvj.2_Missense_Mutation_p.M290I|EGFL6_uc011mik.1_Missense_Mutation_p.M191I	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	290					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						AAAACAGCATGAAAAAGAAGG	0.418													1	0	1.31171e-36	1	1.52327e-36	68	117										T	13635940	G	T	13635940	3	4	68	1	0	0	0	0	1	0	0	0	4963	1290	45	3	900	3	EGFL6	23	13635940	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	10105583	13635940	141634620	1000	21520										
ACE2	59272	broad.mit.edu	37	chrX	15591524	15591524	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atcattagaaacatggaacaGagatgcggggtcacagtatg	12	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:15591524G>A	uc004cxa.1	-	11	1675	c.1507C>T	c.(1507-1509)CTG>TTG	p.L503L	ACE2_uc004cxb.2_Silent_p.L503L	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	503	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	ACATGGAACAGAGATGCGGGG	0.423													0	0	0	1	0	53	135										A	15591524	G	A	15591524	2	1	68	1	0	0	0	0	0	0	0	1	137	933	33	1		1	ACE2	23	15591524	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1955584	15591524	139679036	1001	21521										
REPS2	9185	broad.mit.edu	37	chrX	17080621	17080621	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttattctgagtcactgccggCaaatcaacaacctcgtgact	7	12	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:17080621C>T	uc004cxv.1	+	9	1346	c.1175C>T	c.(1174-1176)GCA>GTA	p.A392V	REPS2_uc004cxw.1_Missense_Mutation_p.A391V|REPS2_uc011miw.1_Missense_Mutation_p.A251V	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	392					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					TCACTGCCGGCAAATCAACAA	0.358													0	0	0	1	0	18	60										T	17080621	C	T	17080621	3	4	68	1	0	0	0	0	1	0	0	0	13229	710	25	2	1209	2	REPS2	23	17080621	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1489097	17080621	138189939	1002	21522										
PHKA2	5256	broad.mit.edu	37	chrX	18913260	18913260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtttttctcatcgtacctctCgggtcgtcgaggatgggagg	14	9	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:18913260C>T	uc004cyv.3	-	31	3762	c.3332G>A	c.(3331-3333)CGA>CAA	p.R1111Q	PHKA2_uc004cyu.3_Missense_Mutation_p.R417Q|PHKA2_uc010nfe.1_Missense_Mutation_p.R143Q|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1111			R -> RTR (in GSD9A; type 2).		glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TCGTACCTCTCGGGTCGTCGA	0.532													0	0	0	1	0	45	131										T	18913260	C	T	18913260	3	4	68	1	0	0	0	0	1	0	0	0	11844	884	31	1	387	1	PHKA2	23	18913260	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1832639	18913260	136357300	1003	21523										
EIF2S3	1968	broad.mit.edu	37	chrX	24086216	24086216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcaatatgctgctccaggcGgtcttattggtaaggatttt	11	7	1	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:24086216G>A	uc004dbc.2	+	9	1024	c.1003G>A	c.(1003-1005)GGT>AGT	p.G335S		NM_001415	NP_001406	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2,	335						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			lung(1)	1						TGCTCCAGGCGGTCTTATTGG	0.363													0	0	0	1	0	24	63										A	24086216	G	A	24086216	3	1	68	1	0	0	0	0	1	0	0	0	5011	1116	39	2	1037	2	EIF2S3	23	24086216	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	5172956	24086216	131184344	1004	21524										
TAB3	257397	broad.mit.edu	37	chrX	30873150	30873150	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggaagaatttgtaaagctCttggtacagtctgtccagaa	11	6	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:30873150C>G	uc004dcj.2	-	6	1295	c.632G>C	c.(631-633)AGA>ACA	p.R211T	TAB3_uc004dck.2_Missense_Mutation_p.R211T|TAB3_uc010ngl.2_Missense_Mutation_p.R211T	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	211	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TTGTAAAGCTCTTGGTACAGT	0.423													0	0	0	1	0	25	52										G	30873150	C	G	30873150	3	3	68	1	0	0	0	0	1	0	0	0	15494	913	32	1	1530	1	TAB3	23	30873150	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	6786934	30873150	124397410	1005	21525										
ATP6AP2	10159	broad.mit.edu	37	chrX	40460059	40460059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atggtgggaatgcagtggtaGagttagtcactgtcaagtca	14	5	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:40460059G>C	uc004det.2	+	8	886	c.784G>C	c.(784-786)GAG>CAG	p.E262Q	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.E186Q|ATP6AP2_uc011mkm.1_Missense_Mutation_p.E230Q|ATP6AP2_uc011mkn.1_Missense_Mutation_p.E184Q|ATP6AP2_uc004deu.1_Missense_Mutation_p.E127Q	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	262	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						TGCAGTGGTAGAGTTAGTCAC	0.373													0	0	0	1	0	19	68										C	40460059	G	C	40460059	3	2	68	1	0	0	0	0	1	0	0	0	1167	943	33	1	814	1	ATP6AP2	23	40460059	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	9586909	40460059	114810501	1006	21526										
USP9X	8239	broad.mit.edu	37	chrX	41010204	41010204	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacaaaagatccaatggataGatcgctttatagaagaactt	7	7	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:41010204G>C	uc004dfb.2	+	13	2290	c.1657G>C	c.(1657-1659)GAT>CAT	p.D553H	USP9X_uc004dfc.2_Missense_Mutation_p.D553H	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	553					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CCAATGGATAGATCGCTTTAT	0.318													0	0	0	1	0	5	20										C	41010204	G	C	41010204	3	2	68	1	0	0	0	0	1	0	0	0	17087	942	33	1	1703	1	USP9X	23	41010204	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	550145	41010204	114260356	1007	21527										
ZNF157	7712	broad.mit.edu	37	chrX	47270104	47270104	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tgcgtggccaaaccagagatGatcttcaagttggagcgagg	14	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:47270104G>A	uc004dhr.1	+	3	294	c.225G>A	c.(223-225)ATG>ATA	p.M75I		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	75	KRAB.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AACCAGAGATGATCTTCAAGT	0.527													0	0	0	1	0	5	9										A	47270104	G	A	47270104	3	1	68	1	0	0	0	0	1	0	0	0	17734	1290	45	1	235	1	ZNF157	23	47270104	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6259900	47270104	108000456	1008	21528										
ZNF41	7592	broad.mit.edu	37	chrX	47307918	47307918	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gattttcttgtgaaagccttCccacattcattgcattcata	5	10	3	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:47307918C>T	uc004dhs.3	-	4	1444	c.1377G>A	c.(1375-1377)GGG>GGA	p.G459G	ZNF41_uc004dhu.3_Silent_p.G451G|ZNF41_uc004dht.3_Silent_p.G331G|ZNF41_uc004dhv.3_Silent_p.G427G|ZNF41_uc004dhw.3_Silent_p.G419G|ZNF41_uc004dhy.3_Silent_p.G417G|ZNF41_uc004dhx.3_Silent_p.G417G|ZNF41_uc011mlm.1_Silent_p.G331G	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	459	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TGAAAGCCTTCCCACATTCAT	0.453													0	0	0	1	0	16	129										T	47307918	C	T	47307918	2	4	68	1	0	0	0	0	0	0	0	1	17886	842	30	1		1	ZNF41	23	47307918	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	37814	47307918	107962642	1009	21529										
FTSJ1	24140	broad.mit.edu	37	chrX	48340027	48340027	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cttcccctggcagaggccttCgctgtctgtcagggctatga	12	13	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:48340027C>T	uc004djo.1	+	9	902	c.579C>T	c.(577-579)TTC>TTT	p.F193F	FTSJ1_uc004djl.2_Silent_p.F193F|FTSJ1_uc004djm.2_Silent_p.F193F|FTSJ1_uc004djn.1_Silent_p.F193F|FTSJ1_uc004djp.1_Silent_p.F193F|FTSJ1_uc011mlw.1_Silent_p.F56F	NM_012280	NP_036412	Q9UET6	RRMJ1_HUMAN	FtsJ homolog 1 isoform a	193					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding				0						CAGAGGCCTTCGCTGTCTGTC	0.647													0	0	0	1	0	7	19										T	48340027	C	T	48340027	2	4	68	1	0	0	0	0	0	0	0	1	6087	883	31	1		1	FTSJ1	23	48340027	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1032109	48340027	106930533	1010	21530										
GRIPAP1	56850	broad.mit.edu	37	chrX	48837884	48837884	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atccactgtgtccttcacctCctgtgggagaaagcaggcat	10	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:48837884C>T	uc004dly.1	-	20	1809	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	GRIPAP1_uc004dlz.2_Missense_Mutation_p.E482K|GRIPAP1_uc004dma.2_Missense_Mutation_p.E513K	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	592	Potential.					early endosome				breast(2)|kidney(1)	3						TCCTTCACCTCCTGTGGGAGA	0.612													0	0	0	1	0	4	29										T	48837884	C	T	48837884	3	4	68	1	0	0	0	0	1	0	0	0	6789	869	30	1	833	1	GRIPAP1	23	48837884	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	497857	48837884	106432676	1011	21531										
WDR45	11152	broad.mit.edu	37	chrX	48933303	48933303	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gggtacccttctgggaggctGaggccactacagtgcctggc	15	12	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:48933303G>C	uc004dmk.1	-	8	798	c.626C>G	c.(625-627)TCA>TGA	p.S209*	PRAF2_uc004dmh.2_5'Flank|PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Nonsense_Mutation_p.S107*|WDR45_uc004dmj.1_Nonsense_Mutation_p.S170*|WDR45_uc004dml.1_Nonsense_Mutation_p.S210*|WDR45_uc004dmm.1_Nonsense_Mutation_p.S174*|WDR45_uc010nim.1_Nonsense_Mutation_p.S209*|WDR45_uc004dmn.1_Nonsense_Mutation_p.S100*|WDR45_uc004dmo.1_Nonsense_Mutation_p.S232*|WDR45_uc004dmp.1_Nonsense_Mutation_p.S210*	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	209	WD 2.				autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding	p.S210*(1)		ovary(1)	1						CTGGGAGGCTGAGGCCACTAC	0.557													0	0	0	1	0	23	26										C	48933303	G	C	48933303	4	2	68	1	0	0	0	0	0	1	0	0	17294	1294	45	1	472	1	WDR45	23	48933303	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	95419	48933303	106337257	1012	21532										
HUWE1	10075	broad.mit.edu	37	chrX	53655540	53655540	+	Frame_Shift_Del	DEL	A	A	-													0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aaagagaagagagcagtggcAaactggtgagggtatggatc							TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:53655540delA	uc004dsp.2	-	15	1548	c.1146delT	c.(1144-1146)TTTfs	p.F382fs		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	382					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GAGCAGTGGCAAACTGGTGAG	0.478																		3	4	---	---								-	53655540	A	-	53655540	7	5	68	1	0	1	0	1	0	0	0	0	7461	127	5	0	12258	0	HUWE1	23	53655540	Frame_Shift_Del	DEL	A	TCGA-DK-A3X1-01A-12D-A22Z-08	4722237	53655540	101615020	1013	21533										
ZXDB	158586	broad.mit.edu	37	chrX	57620058	57620058	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	aggctgctgtgccaggttctCtgctcgcagtagcctctaca	11	13	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:57620058C>A	uc004dvd.2	+	1	1790	c.1577C>A	c.(1576-1578)TCT>TAT	p.S526Y		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	526	Required for interaction with ZXDC (By similarity).|C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCCAGGTTCTCTGCTCGCAGT	0.517													1	0	1.33834e-09	1	1.47404e-09	10	65										A	57620058	C	A	57620058	3	1	68	1	0	0	0	0	1	0	0	0	18248	913	32	3	1579	3	ZXDB	23	57620058	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3964518	57620058	97650502	1014	21534										
KIF4A	24137	broad.mit.edu	37	chrX	69521860	69521860	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	acggctatgaactcccagtcGtcccgatctcatgccatctt	7	15	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:69521860G>A	uc004dyg.2	+	6	754	c.627G>A	c.(625-627)TCG>TCA	p.S209S	KIF4A_uc010nkw.2_Silent_p.S209S|KIF4A_uc004dyf.1_Silent_p.S209S	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	209	Kinesin-motor.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						ACTCCCAGTCGTCCCGATCTC	0.413													0	0	0	1	0	6	96										A	69521860	G	A	69521860	2	1	68	1	0	0	0	0	0	0	0	1	8303	1132	40	2		2	KIF4A	23	69521860	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	11901802	69521860	85748700	1015	21535										
GDPD2	54857	broad.mit.edu	37	chrX	69646312	69646312	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtggcatagcttgcgtgtgtCactgcaggtgagtggccaac	15	9	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:69646312C>T	uc004dyh.2	+	6	706	c.455C>T	c.(454-456)TCA>TTA	p.S152L	GDPD2_uc010nkx.1_Missense_Mutation_p.S152L|GDPD2_uc010nky.1_5'UTR|GDPD2_uc011mpk.1_Missense_Mutation_p.S152L|GDPD2_uc011mpl.1_Missense_Mutation_p.S73L|GDPD2_uc011mpm.1_Missense_Mutation_p.S73L	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	152	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					TTGCGTGTGTCACTGCAGGTG	0.592													0	0	0	1	0	14	17										T	69646312	C	T	69646312	3	4	68	1	0	0	0	0	1	0	0	0	6324	838	29	1	473	1	GDPD2	23	69646312	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	124452	69646312	85624248	1016	21536										
MED12	9968	broad.mit.edu	37	chrX	70360539	70360539	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ataagtaccatgactccaatGagtgcccagggcgtccaggc	11	12	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:70360539G>A	uc004dyy.2	+	42	6298	c.6099G>A	c.(6097-6099)ATG>ATA	p.M2033I	MED12_uc004dyz.2_Missense_Mutation_p.M2032I|MED12_uc004dza.2_Missense_Mutation_p.M1883I|MED12_uc010nla.2_Missense_Mutation_p.M662I	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	2033	Gln-rich.|Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGACTCCAATGAGTGCCCAGG	0.413													0	0	0	1	0	27	108										A	70360539	G	A	70360539	3	1	68	1	0	0	0	0	1	0	0	0	9428	1290	45	1	6265	1	MED12	23	70360539	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	714227	70360539	84910021	1017	21537										
ATP7A	538	broad.mit.edu	37	chrX	77244136	77244136	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	caagctggtgaagtcgtgctGaagatgaaagtggaagggat	16	4	0	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:77244136G>A	uc004ecx.3	+	3	679	c.519G>A	c.(517-519)CTG>CTA	p.L173L	ATP7A_uc004ecw.2_Silent_p.L173L	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	173	HMA 2.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						AAGTCGTGCTGAAGATGAAAG	0.433													0	0	0	1	0	52	253										A	77244136	G	A	77244136	2	1	68	1	0	0	0	0	0	0	0	1	1190	1277	45	1		1	ATP7A	23	77244136	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	6883597	77244136	78026424	1018	21538										
ITM2A	9452	broad.mit.edu	37	chrX	78616609	78616609	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctcttgacagatcttggtctCaacaataaattcgttgggga	9	8	3	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:78616609C>G	uc004edh.2	-	6	1104	c.769G>C	c.(769-771)GAG>CAG	p.E257Q	ITM2A_uc011mqr.1_Missense_Mutation_p.E213Q	NM_004867	NP_004858	O43736	ITM2A_HUMAN	integral membrane protein 2A	257						integral to membrane	protein binding			lung(2)	2						ATCTTGGTCTCAACAATAAAT	0.363													0	0	0	1	0	13	29										G	78616609	C	G	78616609	3	3	68	1	0	0	0	0	1	0	0	0	7912	835	29	1	26	1	ITM2A	23	78616609	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1372473	78616609	76653951	1019	21539										
BRWD3	254065	broad.mit.edu	37	chrX	79932201	79932201	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gtaccaagattcagaggatcCtcagtggacacaaaattgtc	9	9	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:79932201C>G	uc004edt.2	-	41	5579	c.5316G>C	c.(5314-5316)GAG>GAC	p.E1772D	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.E1368D|BRWD3_uc004edp.2_Missense_Mutation_p.E1601D|BRWD3_uc004edq.2_Missense_Mutation_p.E1368D|BRWD3_uc010nmj.1_Missense_Mutation_p.E1368D|BRWD3_uc004edr.2_Missense_Mutation_p.E1442D|BRWD3_uc004eds.2_Missense_Mutation_p.E1368D|BRWD3_uc004edu.2_Missense_Mutation_p.E1442D|BRWD3_uc004edv.2_Missense_Mutation_p.E1368D|BRWD3_uc004edw.2_Missense_Mutation_p.E1368D|BRWD3_uc004edx.2_Missense_Mutation_p.E1368D|BRWD3_uc004edy.2_Missense_Mutation_p.E1368D|BRWD3_uc004edz.2_Missense_Mutation_p.E1442D|BRWD3_uc004eea.2_Missense_Mutation_p.E1442D|BRWD3_uc004eeb.2_Missense_Mutation_p.E1368D|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1772										ovary(4)	4						TCAGAGGATCCTCAGTGGACA	0.398													0	0	0	1	0	10	52										G	79932201	C	G	79932201	3	3	68	1	0	0	0	0	1	0	0	0	1526	680	24	4	96	4	BRWD3	23	79932201	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1315592	79932201	75338359	1020	21540										
CYLC1	1538	broad.mit.edu	37	chrX	83127893	83127893	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tattctaaccaatcttttcaGagacatgacaaaagaaaact	4	8	3	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:83127893G>A	uc004eei.1	+	4	199	c.178_splice	c.e4-1	p.R60_splice	CYLC1_uc004eeh.1_Splice_Site_p.R59_splice	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head						cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						AATCTTTTCAGAGACATGACA	0.294													0	0	0	1	0	4	16										A	83127893	G	A	83127893	5	1	68	1	0	0	0	0	0	0	1	0	4141	956	33	1	191	1	CYLC1	23	83127893	Splice_Site	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3195692	83127893	72142667	1021	21541										
TCEAL1	9338	broad.mit.edu	37	chrX	102885010	102885010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttcctgaggagctcttgcctGagctcctgcctgagatgctc	11	13	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:102885010G>A	uc004eks.2	+	3	340	c.166G>A	c.(166-168)GAG>AAG	p.E56K	TCEAL1_uc004ekt.2_Missense_Mutation_p.E56K|TCEAL1_uc004eku.2_Missense_Mutation_p.E56K	NM_001006640	NP_001006641	Q15170	TCAL1_HUMAN	transcription elongation factor A (SII)-like 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCTCTTGCCTGAGCTCCTGCC	0.642													0	0	0	1	0	11	30										A	102885010	G	A	102885010	3	1	68	1	0	0	0	0	1	0	0	0	15667	1291	45	1	168	1	TCEAL1	23	102885010	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	19757117	102885010	52385550	1022	21542										
ZCCHC18	644353	broad.mit.edu	37	chrX	103359457	103359457	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	taatcaagatgataagggagGaagaggattgggatgatgct	15	2	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:103359457G>T	uc011msh.1	+	3	1971	c.655G>T	c.(655-657)GAA>TAA	p.E219*	MCART6_uc004elu.2_Intron|ZCCHC18_uc011msg.1_Intron	NM_001143978	NP_001137450	P0CG32	ZCC18_HUMAN	zinc finger, CCHC domain containing 18	219							nucleic acid binding|zinc ion binding				0						GATAAGGGAGGAAGAGGATTG	0.502													1	0	0.00909568	1	0.00919788	4	33										T	103359457	G	T	103359457	4	4	68	1	0	0	0	0	0	1	0	0	17583	1175	41	3	657	3	ZCCHC18	23	103359457	Nonsense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	474447	103359457	51911103	1023	21543										
TRPC5	7224	broad.mit.edu	37	chrX	111019659	111019659	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	agtctaaaagtttagaatttGaggagcagatgctggatgca	12	4	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:111019659G>A	uc004epl.1	-	11	3723	c.2804C>T	c.(2803-2805)TCA>TTA	p.S935L		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	935	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TTTAGAATTTGAGGAGCAGAT	0.483													0	0	0	1	0	7	52										A	111019659	G	A	111019659	3	1	68	1	0	0	0	0	1	0	0	0	16579	1294	45	1	121	1	TRPC5	23	111019659	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	7660202	111019659	44250901	1024	21544										
ZCCHC16	340595	broad.mit.edu	37	chrX	111698393	111698393	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacaaaacaggaaatcaatcCtctgatgaatgctaagtttg	7	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:111698393C>G	uc004epo.1	+	3	878	c.437C>G	c.(436-438)CCT>CGT	p.P146R		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	146							nucleic acid binding|zinc ion binding	p.P146L(1)		ovary(1)	1						GAAATCAATCCTCTGATGAAT	0.418													0	0	0	1	0	16	127										G	111698393	C	G	111698393	3	3	68	1	0	0	0	0	1	0	0	0	17581	681	24	4	439	4	ZCCHC16	23	111698393	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	678734	111698393	43572167	1025	21545										
WDR44	54521	broad.mit.edu	37	chrX	117576550	117576550	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	attggtaacctcaaatgactCcagaatcagactatatgatt	6	8	2	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:117576550C>G	uc004eqn.2	+	17	2716	c.2291C>G	c.(2290-2292)TCC>TGC	p.S764C	WDR44_uc004eqo.2_Missense_Mutation_p.S764C|WDR44_uc011mtr.1_Missense_Mutation_p.S675C|WDR44_uc010nqi.2_Missense_Mutation_p.S474C	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	764	WD 5.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						TCAAATGACTCCAGAATCAGA	0.338													0	0	0	1	0	25	49										G	117576550	C	G	117576550	3	3	68	1	0	0	0	0	1	0	0	0	17293	855	30	1	2357	1	WDR44	23	117576550	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	5878157	117576550	37694010	1026	21546										
DOCK11	139818	broad.mit.edu	37	chrX	117679988	117679988	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ttttgttctatttcaggactCatcttctttatgttctcaga	5	8	6	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:117679988C>T	uc004eqp.2	+	6	530	c.467C>T	c.(466-468)TCA>TTA	p.S156L		NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	156					blood coagulation	cytosol	GTP binding			ovary(3)	3						TTTCAGGACTCATCTTCTTTA	0.408													0	0	0	1	0	23	63										T	117679988	C	T	117679988	3	4	68	1	0	0	0	0	1	0	0	0	4686	838	29	1	489	1	DOCK11	23	117679988	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	103438	117679988	37590572	1027	21547										
DOCK11	139818	broad.mit.edu	37	chrX	117761530	117761530	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atagagggagtctgagcactGacaaagacaccggtaattaa	11	7	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:117761530G>A	uc004eqp.2	+	33	3715	c.3652G>A	c.(3652-3654)GAC>AAC	p.D1218N	DOCK11_uc004eqq.2_Missense_Mutation_p.D997N	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1218					blood coagulation	cytosol	GTP binding			ovary(3)	3						TCTGAGCACTGACAAAGACAC	0.383													0	0	0	1	0	12	96										A	117761530	G	A	117761530	3	1	68	1	0	0	0	0	1	0	0	0	4686	1290	45	1	3782	1	DOCK11	23	117761530	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	81542	117761530	37509030	1028	21548										
ZBTB33	10009	broad.mit.edu	37	chrX	119387705	119387705	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cctcctgattctggtgacaaGaaccttgtaatacagaaatc	7	10	1	4			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:119387705G>A	uc004esn.1	+	2	663	c.435G>A	c.(433-435)AAG>AAA	p.K145K	ZBTB33_uc010nqm.1_Silent_p.K145K	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	145					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTGGTGACAAGAACCTTGTAA	0.403													0	0	0	1	0	10	54										A	119387705	G	A	119387705	2	1	68	1	0	0	0	0	0	0	0	1	17533	933	33	1		1	ZBTB33	23	119387705	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1626175	119387705	35882855	1029	21549										
CT47B1	643311	broad.mit.edu	37	chrX	120009116	120009116	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tatctggatgtggtcgttgtGatagaggcggcggagaaggg	19	4	1	3			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:120009116G>A	uc011muc.1	-	1	664	c.409C>T	c.(409-411)CAC>TAC	p.H137Y		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	137											0						TGGTCGTTGTGATAGAGGCGG	0.652													0	0	0	1	0	10	59										A	120009116	G	A	120009116	3	1	68	1	0	0	0	0	1	0	0	0	3989	1290	45	1	498	1	CT47B1	23	120009116	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	621411	120009116	35261444	1030	21550										
STAG2	10735	broad.mit.edu	37	chrX	123179197	123179197	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	actcacaagtcagagcatttCgacatacaagcaccctggca	7	13	2	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:123179197C>A	uc004etz.3	+	7	985	c.646C>A	c.(646-648)CGA>AGA	p.R216R	STAG2_uc004eua.2_Silent_p.R216R|STAG2_uc004eub.2_Silent_p.R216R|STAG2_uc004euc.2_Silent_p.R216R|STAG2_uc004eud.2_Silent_p.R216R|STAG2_uc004eue.2_Silent_p.R216R	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	216					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CAGAGCATTTCGACATACAAG	0.343													1	0	2.16136e-38	1	2.51228e-38	83	139										A	123179197	C	A	123179197	2	1	68	1	0	0	0	0	0	0	0	1	15242	876	31	3		3	STAG2	23	123179197	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3170081	123179197	32091363	1031	21551										
DCAF12L2	340578	broad.mit.edu	37	chrX	125299590	125299590	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	cacaccacctgcctggcgttCagccactgtgacgcgaacac	9	17	1	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:125299590C>A	uc004euk.1	-	1	345	c.318G>T	c.(316-318)CTG>CTT	p.L106L		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	106										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCCTGGCGTTCAGCCACTGTG	0.652													1	0	0.0477658	1	0.0481479	8	75										A	125299590	C	A	125299590	2	1	68	1	0	0	0	0	0	0	0	1	4265	813	29	3		3	DCAF12L2	23	125299590	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2120393	125299590	29970970	1032	21552										
UTP14A	10813	broad.mit.edu	37	chrX	129053376	129053376	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tctcatttgttgtaggcaaaGatgcgacgagcagagcttca	11	8	2	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:129053376G>A	uc004euz.2	+	8	691	c.663G>A	c.(661-663)AAG>AAA	p.K221K	UTP14A_uc011mup.1_Silent_p.K169K|UTP14A_uc011muq.1_Silent_p.K167K|UTP14A_uc004eva.1_5'Flank	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	221	Potential.				rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TGTAGGCAAAGATGCGACGAG	0.517													0	0	0	1	0	43	85										A	129053376	G	A	129053376	2	1	68	1	0	0	0	0	0	0	0	1	17092	933	33	1		1	UTP14A	23	129053376	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	3753786	129053376	26217184	1033	21553										
AFF2	2334	broad.mit.edu	37	chrX	147919173	147919173	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	tttatttttcctcattaggaGatgacccattcctggcctac	6	11	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:147919173G>A	uc004fcp.2	+	5	1568	c.1089G>A	c.(1087-1089)GAG>GAA	p.E363E	AFF2_uc004fco.2_Intron|AFF2_uc004fcq.2_Silent_p.E359E|AFF2_uc004fcr.2_Intron|AFF2_uc011mxb.1_Intron|AFF2_uc004fcs.2_Intron|AFF2_uc011mxc.1_Intron	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	363					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTCATTAGGAGATGACCCATT	0.413													0	0	0	1	0	6	61										A	147919173	G	A	147919173	2	1	68	1	0	0	0	0	0	0	0	1	357	933	33	1		1	AFF2	23	147919173	Silent	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	18865797	147919173	7351387	1034	21554										
IDS	3423	broad.mit.edu	37	chrX	148571931	148571931	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ggcggccgacctgtgtatccAaatatgacacagaggcaaag	12	10	0	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:148571931A>G	uc011mxe.1	-	7	1118	c.920T>C	c.(919-921)TTG>TCG	p.L307S	IDS_uc011mxd.1_5'UTR|IDS_uc011mxf.1_Missense_Mutation_p.L217S|IDS_uc011mxg.1_Missense_Mutation_p.L96S|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Missense_Mutation_p.L96S|IDS_uc011mxh.1_Missense_Mutation_p.L307S|IDS_uc011mxi.1_RNA	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	307						lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CTGTGTATCCAAATATGACAC	0.433													0	0	0	1	0	20	91										G	148571931	A	G	148571931	3	3	68	1	0	0	0	0	1	0	0	0	7503	131	5	5	774	5	IDS	23	148571931	Missense_Mutation	SNP	A	TCGA-DK-A3X1-01A-12D-A22Z-08	652758	148571931	6698629	1035	21555										
MTMR1	8776	broad.mit.edu	37	chrX	149867721	149867721	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	gcttatagctgctacaatttCtagtcagatttcaggttcag	8	8	4	1			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:149867721C>T	uc004fei.2	+	2	335	c.200C>T	c.(199-201)TCT>TTT	p.S67F	MTMR1_uc011mya.1_5'UTR|MTMR1_uc004feg.1_Missense_Mutation_p.S67F|MTMR1_uc004feh.1_Missense_Mutation_p.S67F|MTMR1_uc004fej.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	67						plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GCTACAATTTCTAGTCAGATT	0.353													0	0	0	1	0	18	86										T	149867721	C	T	149867721	3	4	68	1	0	0	0	0	1	0	0	0	9938	913	32	1	206	1	MTMR1	23	149867721	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	1295790	149867721	5402839	1036	21556										
RENBP	5973	broad.mit.edu	37	chrX	153205672	153205672	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtgtggccaccagagcttCatggcccactccagctgagg	12	14	1	2			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:153205672C>T	uc004fjo.1	-	9	1130	c.960G>A	c.(958-960)ATG>ATA	p.M320I		NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	320					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	ACCAGAGCTTCATGGCCCACT	0.602													0	0	0	1	0	11	51										T	153205672	C	T	153205672	3	4	68	1	0	0	0	0	1	0	0	0	13225	826	29	1	335	1	RENBP	23	153205672	Missense_Mutation	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	3337951	153205672	2064888	1037	21557										
RENBP	5973	broad.mit.edu	37	chrX	153207433	153207433	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	ctgtctccccaggcagccagGaagttccttgccaccctctg	9	17	2	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:153207433G>T	uc004fjo.1	-	7	909	c.739C>A	c.(739-741)CCT>ACT	p.P247T	RENBP_uc011mzh.1_Intron	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	247					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	AGGCAGCCAGGAAGTTCCTTG	0.632													1	0	1.30475e-32	1	1.5138e-32	39	80										T	153207433	G	T	153207433	3	4	68	1	0	0	0	0	1	0	0	0	13225	1174	41	3	564	3	RENBP	23	153207433	Missense_Mutation	SNP	G	TCGA-DK-A3X1-01A-12D-A22Z-08	1761	153207433	2063127	1038	21558										
IL9R	3581	broad.mit.edu	37	chrX	155232650	155232650	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.538238141335915	556	1.24425314255849e-224	4.26635240908017	4.95000884378453	3.86131821946286	2.31957706152461e-05	0.000177379422351882	426	atctgcatctgcacctgtgtCtgcttgggagtctctgtcac	10	12	5	0			TCGA-DK-A3X1-01A-12D-A22Z-08	TCGA-DK-A3X1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f91af229-2799-4767-8354-c837196d9224	bb1cef54-4751-40af-ba45-43a9a313bc89	g.chrX:155232650C>T	uc004fnv.1	+	2	287	c.108C>T	c.(106-108)GTC>GTT	p.V36V	IL9R_uc010nvn.2_Silent_p.V15V|IL9R_uc004fnu.1_Silent_p.V83V	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	36					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCACCTGTGTCTGCTTGGGAG	0.607													0	0	0	1	0	12	113										T	155232650	C	T	155232650	2	4	68	1	0	0	0	0	0	0	0	1	7708	900	32	1		1	IL9R	23	155232650	Silent	SNP	C	TCGA-DK-A3X1-01A-12D-A22Z-08	2025217	155232650	37910	1039	21559										
CDK11A	728642	broad.mit.edu	37	chr1	1634992	1634992	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttgttgtaggggtgctcgctGaaggtcatctttttgactac	12	7	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:1634992G>A	uc009vks.2	-	18	2091	c.1983C>T	c.(1981-1983)TTC>TTT	p.F661F	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Silent_p.F168F|CDK11A_uc009vkp.2_Silent_p.F278F|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Silent_p.F651F	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	664					apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GGTGCTCGCTGAAGGTCATCT	0.587													0	0	0	0.000602	0	4	15										A	1634992	G	A	1634992	2	1	69	1	0	0	0	0	0	0	0	1	3126	1281	45	1		1	CDK11A	1	1634992	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		1634992	247615629	1	21560										
GNB1	2782	broad.mit.edu	37	chr1	1756890	1756890	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cgtaactggtcaagctcactCatcttccgatcttagtgctc	7	13	5	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:1756890C>A	uc001aif.2	-	3	335	c.3G>T	c.(1-3)ATG>ATT	p.M1I	GNB1_uc009vky.2_5'UTR	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	1					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		CAAGCTCACTCATCTTCCGAT	0.398													1	0	2.4537e-52	0.01441	2.86817e-52	129	128										A	1756890	C	A	1756890	3	1	69	1	0	0	0	0	1	0	0	0	6515	826	29	3	1055	3	GNB1	1	1756890	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	121898	1756890	247493731	2	21561										
SLC45A1	50651	broad.mit.edu	37	chr1	8403885	8403885	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgagctgccagtacttcctgGctcagattctggtctccctg	10	13	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:8403885G>T	uc001apb.2	+	8	2059	c.2059G>T	c.(2059-2061)GCT>TCT	p.A687S	SLC45A1_uc001apc.2_Missense_Mutation_p.A385S	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	687	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GTACTTCCTGGCTCAGATTCT	0.642													1	0	3.51602e-12	0.008871	3.81361e-12	17	57										T	8403885	G	T	8403885	3	4	69	1	0	0	0	0	1	0	0	0	14640	1203	42	4	2089	4	SLC45A1	1	8403885	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	6646995	8403885	240846736	3	21562										
KLHDC7A	127707	broad.mit.edu	37	chr1	18807481	18807497	+	Frame_Shift_Del	DEL	CCCCAGAGGAGCAGAGG	CCCCAGAGGAGCAGAGG	-													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gttggctggagaagcatgttCcccagaggagcagaggccca							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:18807481_18807497delCCCCAGAGGAGCAGAGG	uc001bax.2	+	1	58_74	c.6_22delCCCCAGAGGAGCAGAGG	c.(4-24)TTCCCCAGAGGAGCAGAGGCCfs	p.F2fs	KLHDC7A_uc009vpg.2_5'Flank	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	2_8						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCATGTTCCCCAGAGGAGCAGAGGCCCAGGACTG	0.581																		15	31	---	---								-	18807497	CCCCAGAGGAGCAGAGG	-	18807481	7	5	69	1	0	1	0	1	0	0	0	0	8360	854	30	0	8	0	KLHDC7A	1	18807481	Frame_Shift_Del	DEL	CCCCAGAGGAGCAGAGG	TCGA-E5-A2PC-01A-11D-A202-08	10403596	18807481	230443140	4	21563										
UBR4	23352	broad.mit.edu	37	chr1	19487579	19487579	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tctgaaatcctgggttcactCtgaaatgccgactccttcat	7	12	4	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:19487579C>T	uc001bbi.2	-	38	5242	c.5238G>A	c.(5236-5238)CAG>CAA	p.Q1746Q	UBR4_uc001bbm.1_Silent_p.Q957Q	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1746					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGGTTCACTCTGAAATGCCG	0.517													0	0	0	0.00308	0	8	23										T	19487579	C	T	19487579	2	4	69	1	0	0	0	0	0	0	0	1	16901	912	32	1		1	UBR4	1	19487579	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	680098	19487579	229763042	5	21564										
LDLRAP1	26119	broad.mit.edu	37	chr1	25893369	25893369	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tctcggacaaaccctcaggtCctggacactggcctgacagc	10	15	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:25893369C>T	uc001bkl.3	+	9	927	c.813C>T	c.(811-813)GTC>GTT	p.V271V	LDLRAP1_uc009vrw.2_RNA|LDLRAP1_uc009vrx.2_Silent_p.V101V	NM_015627	NP_056442	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein	271	AP-2 complex binding.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCTCAGGTCCTGGACACTG	0.657													0	0	0	0.000602	0	5	10										T	25893369	C	T	25893369	2	4	69	1	0	0	0	0	0	0	0	1	8708	842	30	1		1	LDLRAP1	1	25893369	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	6405790	25893369	223357252	6	21565										
POU3F1	5453	broad.mit.edu	37	chr1	38511353	38511353	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcacttgagaaagtggctctCgagcgcgcctttgaccccca	11	14	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:38511353C>T	uc001ccp.1	-	1	1098	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	355	Homeobox.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AAGTGGCTCTCGAGCGCGCCT	0.662													0	0	0	0.001168	0	6	10										T	38511353	C	T	38511353	3	4	69	1	0	0	0	0	1	0	0	0	12274	893	31	1	296	1	POU3F1	1	38511353	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	12617984	38511353	210739268	7	21566										
HPCAL4	51440	broad.mit.edu	37	chr1	40150121	40150121	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccggccgcccaccttgatgTagagctgctgaaactcctcc	10	16	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:40150121T>A	uc001cdr.2	-	2	275	c.155A>T	c.(154-156)TAC>TTC	p.Y52F	HPCAL4_uc010oix.1_Missense_Mutation_p.Y52F	NM_016257	NP_057341	Q9UM19	HPCL4_HUMAN	hippocalcin-like protein 4	52	EF-hand 1.				central nervous system development	intracellular	calcium ion binding			central_nervous_system(1)	1	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CACCTTGATGTAGAGCTGCTG	0.632													0	0	0	0.006122	0	14	14										A	40150121	T	A	40150121	3	1	69	1	0	0	0	0	1	0	0	0	7331	1638	57	5	432	5	HPCAL4	1	40150121	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	1638768	40150121	209100500	8	21567										
POMGNT1	55624	broad.mit.edu	37	chr1	46655654	46655654	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cttgctgtggtccagaacctCagcctcactgcagtagaggg	12	12	2	2	rs150351855		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:46655654C>T	uc001cpe.2	-	20	1821	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	POMGNT1_uc010olx.1_Missense_Mutation_p.E531K|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Missense_Mutation_p.E410K|POMGNT1_uc001cpg.2_Missense_Mutation_p.E553K|POMGNT1_uc001cpf.2_Missense_Mutation_p.E220K	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	553	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TCCAGAACCTCAGCCTCACTG	0.443													0	0	0	0.009096	0	3	16										T	46655654	C	T	46655654	3	4	69	1	0	0	0	0	1	0	0	0	12243	835	29	1	337	1	POMGNT1	1	46655654	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	6505533	46655654	202594967	9	21568										
LRRC41	10489	broad.mit.edu	37	chr1	46744864	46744864	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctcatgtacctgatgtccaGctgacagagagaggaggatg	13	9	1	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:46744864G>C	uc001cpn.2	-	9	2253	c.2209C>G	c.(2209-2211)CTG>GTG	p.L737V	LRRC41_uc010omb.1_3'UTR	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	737	LRR 7.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CTGATGTCCAGCTGACAGAGA	0.532													0	0	0	0.007291	0	24	17										C	46744864	G	C	46744864	3	2	69	1	0	0	0	0	1	0	0	0	8999	962	34	4	237	4	LRRC41	1	46744864	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	89210	46744864	202505757	10	21569										
FAF1	11124	broad.mit.edu	37	chr1	50941244	50941244	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttgctggccaggaaacgccgCtccaagaactcgccactggg	12	14	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:50941244C>T	uc009vyx.1	-	19	1824	c.1761G>A	c.(1759-1761)GAG>GAA	p.E587E	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Silent_p.E587E|FAF1_uc010onc.1_Silent_p.E345E	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	587	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		GGAAACGCCGCTCCAAGAACT	0.522													0	0	0	0.009096	0	4	26										T	50941244	C	T	50941244	2	4	69	1	0	0	0	0	0	0	0	1	5369	796	28	2		2	FAF1	1	50941244	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4196380	50941244	198309377	11	21570										
CDC7	8317	broad.mit.edu	37	chr1	91967346	91967346	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agcgtgaccggtttcaggctGaaggctctttaaaaaaaaac	10	8	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:91967346G>A	uc001doe.2	+	2	238	c.73G>A	c.(73-75)GAA>AAA	p.E25K	CDC7_uc001dof.2_Missense_Mutation_p.E25K|CDC7_uc010osw.1_Missense_Mutation_p.E25K|CDC7_uc009wdc.2_Missense_Mutation_p.E25K	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	25					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		GTTTCAGGCTGAAGGCTCTTT	0.413													0	0	0	0.003954	0	24	90										A	91967346	G	A	91967346	3	1	69	1	0	0	0	0	1	0	0	0	3084	1291	45	1	75	1	CDC7	1	91967346	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	41026102	91967346	157283275	12	21571										
GLMN	11146	broad.mit.edu	37	chr1	92757089	92757089	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttccagcccatattcttgatGatgacctgtaaaaacatttt	5	9	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:92757089G>A	uc001dor.2	-	4	286	c.171C>T	c.(169-171)ATC>ATT	p.I57I	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Silent_p.I57I	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	57					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		TATTCTTGATGATGACCTGTA	0.373									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				0	0	0	0.010729	0	9	25										A	92757089	G	A	92757089	2	1	69	1	0	0	0	0	0	0	0	1	6448	1280	45	1		1	GLMN	1	92757089	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	789743	92757089	156493532	13	21572										
CCDC18	343099	broad.mit.edu	37	chr1	93646208	93646208	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cccggcaagccccgcgccttCggcggcgcctcacgcagtct	12	20	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:93646208C>T	uc001dpq.2	+	1	289	c.121C>T	c.(121-123)CGG>TGG	p.R41W	TMED5_uc001dpn.2_5'UTR|TMED5_uc001dpo.2_5'UTR|TMED5_uc001dpp.2_RNA	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	Error:Variant_position_missing_in_Q5T9S5_after_alignment										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		CCCGCGCCTTCGGCGGCGCCT	0.721													0	0	0	0.007413	0	20	9										T	93646208	C	T	93646208	3	4	69	1	0	0	0	0	1	0	0	0	2794	875	31	1	123	1	CCDC18	1	93646208	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	889119	93646208	155604413	14	21573										
KCNA2	3737	broad.mit.edu	37	chr1	111147122	111147122	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aggtcgcctcaatcggccccCtgactggtagtagtacaaaa	10	12	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:111147122C>A	uc001dzu.2	-	2	779	c.283G>T	c.(283-285)GGG>TGG	p.G95W	KCNA2_uc009wfv.1_Missense_Mutation_p.G95W|KCNA2_uc009wfw.2_Missense_Mutation_p.G95W	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	95						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		AATCGGCCCCCTGACTGGTAG	0.473													1	0	0.000978159	0.010729	0.00101028	12	48										A	111147122	C	A	111147122	3	1	69	1	0	0	0	0	1	0	0	0	8003	681	24	4	1220	4	KCNA2	1	111147122	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	17500914	111147122	138103499	15	21574										
SIKE1	80143	broad.mit.edu	37	chr1	115318966	115318966	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctaaattagctacaatcttaCctctaattgggctaattttt	4	8	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:115318966C>T	uc001efo.3	-	4	602	c.522_splice	c.e4+1	p.E174_splice	SIKE1_uc001efp.3_Splice_Site_p.E178_splice	NM_025073	NP_079349	Q9BRV8	SIKE1_HUMAN	suppressor of IKK epsilon isoform 2							cytosol	protein binding				0						TACAATCTTACCTCTAATTGG	0.373													0	0	0	0.00499	0	17	62										T	115318966	C	T	115318966	5	4	69	1	0	0	0	0	0	0	1	0	14320	521	18	2	108	2	SIKE1	1	115318966	Splice_Site	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4171844	115318966	133931655	16	21575										
SPAG17	200162	broad.mit.edu	37	chr1	118640299	118640299	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atgtgtgtactaaccatcatCtcaccatctgaccagtcaga	6	12	4	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:118640299C>T	uc001ehk.2	-	7	1073	c.1005G>A	c.(1003-1005)GAG>GAA	p.E335E		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	335						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TAACCATCATCTCACCATCTG	0.348													0	0	0	0.004482	0	6	18										T	118640299	C	T	118640299	2	4	69	1	0	0	0	0	0	0	0	1	14979	912	32	1		1	SPAG17	1	118640299	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	3321333	118640299	130610322	17	21576										
SETDB1	9869	broad.mit.edu	37	chr1	150923028	150923028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atggcatgctggagcgggccCcagcagagccctcctaccgt	13	15	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:150923028C>T	uc001evu.2	+	13	1865	c.1675C>T	c.(1675-1677)CCA>TCA	p.P559S	SETDB1_uc009wmf.2_Missense_Mutation_p.P560S|SETDB1_uc001evv.2_Missense_Mutation_p.P559S|SETDB1_uc009wmg.1_Missense_Mutation_p.P559S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAGCGGGCCCCAGCAGAGCC	0.587													0	0	0	0.00632	0	29	179										T	150923028	C	T	150923028	3	4	69	1	0	0	0	0	1	0	0	0	14138	623	22	2	1721	2	SETDB1	1	150923028	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	32282729	150923028	98327593	18	21577										
SHE	126669	broad.mit.edu	37	chr1	154459062	154459062	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccctcactgtggtccgagagGgctggcttcaggatcttctg	13	12	4	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:154459062G>T	uc001ffb.2	-	4	1209	c.1122C>A	c.(1120-1122)GCC>GCA	p.A374A	SHE_uc001ffc.2_RNA	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	374										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGTCCGAGAGGGCTGGCTTCA	0.597													1	0	1.32181e-22	0.007291	1.4995e-22	29	106										T	154459062	G	T	154459062	2	4	69	1	0	0	0	0	0	0	0	1	14276	1219	43	4		4	SHE	1	154459062	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3536034	154459062	94791559	19	21578										
DCST1	149095	broad.mit.edu	37	chr1	155013956	155013956	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcccaggtgaatagtgagacGggctacacgcctgaggatac	14	10	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155013956G>T	uc001fgn.1	+	7	711	c.615G>T	c.(613-615)ACG>ACT	p.T205T	DCST1_uc010per.1_Silent_p.T230T|DCST1_uc010pes.1_Silent_p.T180T	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	205	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			ATAGTGAGACGGGCTACACGC	0.587													1	0	6.42651e-13	0.010729	6.99237e-13	12	87										T	155013956	G	T	155013956	2	4	69	1	0	0	0	0	0	0	0	1	4302	1103	39	4		4	DCST1	1	155013956	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	554894	155013956	94236665	20	21579										
DCST1	149095	broad.mit.edu	37	chr1	155023327	155023327	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttagtgacagcaacgacgacActgcctacgcggggtgaaga	13	10	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155023327A>G	uc001fgn.1	+	17	2200	c.2104A>G	c.(2104-2106)ACT>GCT	p.T702A	DCST1_uc010pes.1_Missense_Mutation_p.T677A|uc001fgo.2_RNA|ADAM15_uc001fgq.1_5'Flank|ADAM15_uc009wpc.1_5'Flank|ADAM15_uc010pet.1_5'Flank|ADAM15_uc010peu.1_5'Flank|ADAM15_uc001fgt.1_5'Flank|ADAM15_uc010pev.1_5'Flank|ADAM15_uc001fgs.1_5'Flank|ADAM15_uc001fgr.1_5'Flank|ADAM15_uc001fgu.1_5'Flank|ADAM15_uc001fgw.1_5'Flank|ADAM15_uc001fgv.1_5'Flank|ADAM15_uc001fgx.1_5'Flank|ADAM15_uc001fgz.1_5'Flank|ADAM15_uc001fgy.1_5'Flank|ADAM15_uc001fha.1_5'Flank	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	702	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CAACGACGACACTGCCTACGC	0.637											OREG0013846	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	22	12										G	155023327	A	G	155023327	3	3	69	1	0	0	0	0	1	0	0	0	4302	159	6	5	2166	5	DCST1	1	155023327	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	9371	155023327	94227294	21	21580										
SCAMP3	10067	broad.mit.edu	37	chr1	155226174	155226174	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaattcttgctgggccttctGaaagctggcacctgtgcggc	12	11	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155226174G>A	uc001fjs.2	-	9	1187	c.934C>T	c.(934-936)CAG>TAG	p.Q312*	RAG1AP1_uc010pey.1_Intron|FAM189B_uc001fjm.2_5'Flank|FAM189B_uc001fjn.2_5'Flank|FAM189B_uc001fjo.2_5'Flank|FAM189B_uc001fjp.2_5'Flank|FAM189B_uc001fjq.1_5'Flank|SCAMP3_uc001fjr.2_Nonsense_Mutation_p.Q159*|SCAMP3_uc001fju.2_Nonsense_Mutation_p.Q298*|SCAMP3_uc001fjv.2_3'UTR|SCAMP3_uc001fjt.2_Nonsense_Mutation_p.Q286*	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	312	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGGCCTTCTGAAAGCTGGCA	0.582													0	0	0	0.01441	0	46	236										A	155226174	G	A	155226174	4	1	69	1	0	0	0	0	0	1	0	0	13872	1299	45	1	113	1	SCAMP3	1	155226174	Nonsense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	202847	155226174	94024447	22	21581										
GON4L	54856	broad.mit.edu	37	chr1	155736062	155736062	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agcaggcagtgctgcaggagActcaaaactctcacctccac	9	14	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:155736062A>G	uc001flz.2	-	21	3299	c.3202T>C	c.(3202-3204)TCT>CCT	p.S1068P	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Missense_Mutation_p.S1068P|GON4L_uc009wrh.1_Missense_Mutation_p.S1068P|GON4L_uc001fma.1_Missense_Mutation_p.S1068P|GON4L_uc001fmb.3_Missense_Mutation_p.S264P|GON4L_uc001fmc.2_Missense_Mutation_p.S1068P|GON4L_uc001fmd.3_Missense_Mutation_p.S1068P|GON4L_uc009wri.2_Missense_Mutation_p.S654P	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1068					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GCTGCAGGAGACTCAAAACTC	0.567													0	0	0	0.01441	0	52	13										G	155736062	A	G	155736062	3	3	69	1	0	0	0	0	1	0	0	0	6572	275	10	5	3685	5	GON4L	1	155736062	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	509888	155736062	93514559	23	21582										
CD84	8832	broad.mit.edu	37	chr1	160520800	160520800	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cttgaagccatgatatatgtGtatatggttttctttgaggc	10	5	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:160520800G>T	uc001fwh.3	-	6	861	c.837C>A	c.(835-837)TAC>TAA	p.Y279*	CD84_uc001fwf.3_Nonsense_Mutation_p.Y262*|CD84_uc001fwg.3_Nonsense_Mutation_p.Y273*|CD84_uc009wtn.2_Intron|CD84_uc001fwi.3_Nonsense_Mutation_p.Y148*	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	279	Cytoplasmic (Potential).|ITSM motif 1.			Y->F: Reduced tyrosine phosphorylation, reduced binding of SH2D1B and loss of binding of SH2D1A.	blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGATATATGTGTATATGGTTT	0.378													1	0	2.26627e-22	0.007835	2.55417e-22	40	79										T	160520800	G	T	160520800	4	4	69	1	0	0	0	0	0	1	0	0	3042	1372	48	4	212	4	CD84	1	160520800	Nonsense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	4784738	160520800	88729821	24	21583										
LMX1A	4009	broad.mit.edu	37	chr1	165173230	165173230	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gaaacaatcacccaggttacTgagggaggtgtcgtcgctat	12	9	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:165173230T>A	uc001gcy.1	-	8	1257	c.1036A>T	c.(1036-1038)AGT>TGT	p.S346C	LMX1A_uc001gcz.1_Missense_Mutation_p.S346C|LMX1A_uc001gcw.1_Missense_Mutation_p.S64C|LMX1A_uc001gcx.1_Missense_Mutation_p.S97C	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	346						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CCCAGGTTACTGAGGGAGGTG	0.507													0	0	0	0.00308	0	8	86										A	165173230	T	A	165173230	3	1	69	1	0	0	0	0	1	0	0	0	8861	1580	55	5	116	5	LMX1A	1	165173230	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	4652430	165173230	84077391	25	21584										
SCYL3	57147	broad.mit.edu	37	chr1	169857941	169857941	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtaaggtaaatggtggttctCtcagtgtatagctctttaaa	10	5	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:169857941C>G	uc001ggs.2	-	2	239	c.41G>C	c.(40-42)AGA>ACA	p.R14T	SCYL3_uc001ggt.2_Missense_Mutation_p.R14T|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	14	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGGTGGTTCTCTCAGTGTATA	0.423													0	0	0	0.008291	0	10	72										G	169857941	C	G	169857941	3	3	69	1	0	0	0	0	1	0	0	0	13949	913	32	1	2239	1	SCYL3	1	169857941	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4684711	169857941	79392680	26	21585										
LHX4	89884	broad.mit.edu	37	chr1	180217472	180217472	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atcctggacaagttcatcctGaaggtcctggacagacactg	10	11	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:180217472G>A	uc001goe.1	+	2	352	c.129G>A	c.(127-129)CTG>CTA	p.L43L		NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	43	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGTTCATCCTGAAGGTCCTGG	0.592													0	0	0	0.00308	0	8	49										A	180217472	G	A	180217472	2	1	69	1	0	0	0	0	0	0	0	1	8773	1277	45	1		1	LHX4	1	180217472	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	10359531	180217472	69033149	27	21586										
ASPM	259266	broad.mit.edu	37	chr1	197112811	197112811	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gttttcacaagcttgtagtgGgctcctaactctgtcaactt	8	10	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:197112811G>A	uc001gtu.2	-	3	828	c.571C>T	c.(571-573)CCA>TCA	p.P191S	ASPM_uc001gtv.2_Missense_Mutation_p.P191S|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	191					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						GCTTGTAGTGGGCTCCTAACT	0.353													0	0	0	0.01441	0	85	14										A	197112811	G	A	197112811	3	1	69	1	0	0	0	0	1	0	0	0	1056	1232	43	2	9966	2	ASPM	1	197112811	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	16895339	197112811	52137810	28	21587										
ELF3	1999	broad.mit.edu	37	chr1	201983137	201983153	+	Splice_Site	DEL	TGAGCCGGGCCATGAGG	TGAGCCGGGCCATGAGG	-													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	caacatgacctacgagaagcTgagccgggccatgaggtgag							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			TGAGCCGGGCCATGAGG	-	TGAGCCGGGCCATGAGG	TGAGCCGGGCCATGAGG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:201983137_201983153delTGAGCCGGGCCATGAGG	uc001gxg.3	+	7	4193	c.1001_splice	c.e7+1	p.R334_splice	ELF3_uc001gxi.3_Splice_Site_p.R334_splice|ELF3_uc001gxh.3_Splice_Site_p.R334_splice	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription						epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						TACGAGAAGCTGAGCCGGGCCATGAGGTGAGCTGGCG	0.59																		14	3	---	---								-	201983153	TGAGCCGGGCCATGAGG	-	201983137	8	5	69	1	0	1	0	1	0	0	1	0	5055	1580	55	0	1012	0	ELF3	1	201983137	Splice_Site	DEL	TGAGCCGGGCCATGAGG	TCGA-E5-A2PC-01A-11D-A202-08	4870326	201983137	47267484	29	21588										
PIK3C2B	5287	broad.mit.edu	37	chr1	204412707	204412707	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atgctgaactgagagtccttGaggccgtccttcagtaacct	10	11	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:204412707G>A	uc001haw.2	-	20	3365	c.2886C>T	c.(2884-2886)CTC>CTT	p.L962L	PIK3C2B_uc010pqv.1_Silent_p.L934L	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	962					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAGAGTCCTTGAGGCCGTCCT	0.587													0	0	0	0.01441	0	151	24										A	204412707	G	A	204412707	2	1	69	1	0	0	0	0	0	0	0	1	11910	1277	45	1		1	PIK3C2B	1	204412707	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	2429570	204412707	44837914	30	21589										
LYST	1130	broad.mit.edu	37	chr1	235973787	235973787	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggatctttgtgaacttgagtTcttttctttggtcaggatta	10	5	4	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:235973787T>A	uc001hxj.2	-	5	506	c.331A>T	c.(331-333)AAC>TAC	p.N111Y	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.N111Y	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	111					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GAACTTGAGTTCTTTTCTTTG	0.348									Chediak-Higashi_syndrome				0	0	0	0.012213	0	33	9										A	235973787	T	A	235973787	3	1	69	1	0	0	0	0	1	0	0	0	9128	1783	62	5	11270	5	LYST	1	235973787	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	31561080	235973787	13276834	31	21590										
TRIM58	25893	broad.mit.edu	37	chr1	248028105	248028105	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cggcagctgaggcggctggaGgcggaggagcgagcgacgct	21	10	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr1:248028105G>A	uc001ido.2	+	3	663	c.615G>A	c.(613-615)GAG>GAA	p.E205E		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	205	Potential.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCGGCTGGAGGCGGAGGAGC	0.622													0	0	0	0.010771	0	42	8										A	248028105	G	A	248028105	2	1	69	1	0	0	0	0	0	0	0	1	16528	991	35	2		2	TRIM58	1	248028105	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	12054318	248028105	1222516	32	21591										
NT5C1B	93034	broad.mit.edu	37	chr2	18764238	18764238	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	catcaggatatagatcacggAgtctagcattgacatactgt	9	8	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:18764238A>T	uc002rcz.2	-	7	1201	c.1097T>A	c.(1096-1098)CTC>CAC	p.L366H	NT5C1B_uc002rcy.2_Missense_Mutation_p.L366H|NT5C1B_uc010exr.2_Missense_Mutation_p.L308H|NT5C1B_uc010yju.1_Missense_Mutation_p.L306H|NT5C1B_uc002rda.2_Missense_Mutation_p.L306H|NT5C1B_uc010yjv.1_Missense_Mutation_p.L383H|NT5C1B_uc010yjw.1_Missense_Mutation_p.L349H|NT5C1B_uc010exs.2_Missense_Mutation_p.L368H	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	366					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TAGATCACGGAGTCTAGCATT	0.473													0	0	0	0.004482	0	8	39										T	18764238	A	T	18764238	3	4	69	1	0	0	0	0	1	0	0	0	10686	304	11	5	751	5	NT5C1B	2	18764238	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08		18764238	224435135	33	21592										
RHOB	388	broad.mit.edu	37	chr2	20647740	20647740	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaggcgtgcgcgaggtcttcGagacggccacgcgcgccgcg	17	14	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:20647740G>A	uc002rdv.2	+	1	906	c.514G>A	c.(514-516)GAG>AAG	p.E172K		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	172					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CGAGGTCTTCGAGACGGCCAC	0.687													0	0	0	0.01441	0	58	75										A	20647740	G	A	20647740	3	1	69	1	0	0	0	0	1	0	0	0	13332	1059	37	1	516	1	RHOB	2	20647740	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	1883502	20647740	222551633	34	21593										
XDH	7498	broad.mit.edu	37	chr2	31562461	31562461	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcttgtaggtgctagggccaCgggtgtgcaggctcccctcg	15	12	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:31562461C>T	uc002rnv.1	-	34	3747	c.3668G>A	c.(3667-3669)CGT>CAT	p.R1223H		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1223					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GCTAGGGCCACGGGTGTGCAG	0.597													0	0	0	0.003271	0	35	56										T	31562461	C	T	31562461	3	4	69	1	0	0	0	0	1	0	0	0	17423	536	19	2	345	2	XDH	2	31562461	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	10914721	31562461	211636912	35	21594										
BIRC6	57448	broad.mit.edu	37	chr2	32626345	32626345	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcacagtttccttgtacggaTggaactgacagaatatcttg	10	8	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:32626345T>C	uc010ezu.2	+	7	1283	c.1149T>C	c.(1147-1149)GAT>GAC	p.D383D		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	383					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTTGTACGGATGGAACTGACA	0.473													0	0	0	0.01441	0	85	130										C	32626345	T	C	32626345	2	2	69	1	0	0	0	0	0	0	0	1	1438	1461	51	5		5	BIRC6	2	32626345	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	1063884	32626345	210573028	36	21595										
SLC8A1	6546	broad.mit.edu	37	chr2	40656252	40656252	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgacctcgtgcatgctgacaGccttccttgcttggtcagct	10	13	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:40656252G>A	uc002rrx.2	-	1	1193	c.1169C>T	c.(1168-1170)GCT>GTT	p.A390V	SLC8A1_uc002rry.2_Missense_Mutation_p.A390V|SLC8A1_uc002rrz.2_Missense_Mutation_p.A390V|SLC8A1_uc002rsa.2_Missense_Mutation_p.A390V|SLC8A1_uc002rsd.3_Missense_Mutation_p.A390V|SLC8A1_uc002rsb.1_Missense_Mutation_p.A390V|SLC8A1_uc010fan.1_Missense_Mutation_p.A390V|SLC8A1_uc002rsc.1_Missense_Mutation_p.A390V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	390	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CATGCTGACAGCCTTCCTTGC	0.453													0	0	0	0.006214	0	8	15										A	40656252	G	A	40656252	3	1	69	1	0	0	0	0	1	0	0	0	14706	971	34	2	1900	2	SLC8A1	2	40656252	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	8029907	40656252	202543121	37	21596										
CYP26B1	56603	broad.mit.edu	37	chr2	72371249	72371249	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gaggatcttgcgcacgttctCcgcgccggtcacgcgtatca	12	14	4	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:72371249C>T	uc002sih.1	-	2	298	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CYP26B1_uc010yra.1_Missense_Mutation_p.E83K|CYP26B1_uc010yrb.1_Intron	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	100					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						CGCACGTTCTCCGCGCCGGTC	0.637													0	0	0	0.012213	0	35	59										T	72371249	C	T	72371249	3	4	69	1	0	0	0	0	1	0	0	0	4156	864	30	1	1260	1	CYP26B1	2	72371249	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	31714997	72371249	170828124	38	21597										
MTHFD2	10797	broad.mit.edu	37	chr2	74432979	74432979	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gagaatcctgcaagtcactcCtatgtcctcaacaaaaccag	6	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:74432979C>G	uc002skk.2	+	2	328	c.249C>G	c.(247-249)TCC>TCG	p.S83S	MTHFD2_uc002skj.2_5'UTR|MTHFD2_uc010yro.1_Intron|MTHFD2_uc010ffb.2_Silent_p.S83S|MTHFD2_uc010yrp.1_Intron	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	83					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAAGTCACTCCTATGTCCTCA	0.532													0	0	0	0.01441	0	41	56										G	74432979	C	G	74432979	2	3	69	1	0	0	0	0	0	0	0	1	9929	668	24	4		4	MTHFD2	2	74432979	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2061730	74432979	168766394	39	21598										
KDM3A	55818	broad.mit.edu	37	chr2	86669240	86669240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttctcagtctgtccgcagccGacggcagcgatggcagccac	12	15	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:86669240G>A	uc002sri.3	+	2	397	c.70G>A	c.(70-72)GAC>AAC	p.D24N	KDM3A_uc010ytj.1_Missense_Mutation_p.D24N|KDM3A_uc010ytk.1_Missense_Mutation_p.D24N	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	24				D -> G (in Ref. 2; CAH18459/CAH18373).	androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GTCCGCAGCCGACGGCAGCGA	0.642													0	0	0	0.004289	0	37	50										A	86669240	G	A	86669240	3	1	69	1	0	0	0	0	1	0	0	0	8126	1058	37	1	72	1	KDM3A	2	86669240	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	12236261	86669240	156530133	40	21599										
EIF2AK3	9451	broad.mit.edu	37	chr2	88885403	88885403	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctgcgcacaataaacgttgTtgctatgatacaaaacaaaa	6	9	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:88885403T>C	uc002stc.3	-	9	1808	c.1606A>G	c.(1606-1608)ACA>GCA	p.T536A		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	536	Cytoplasmic (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						ATAAACGTTGTTGCTATGATA	0.343													0	0	0	0.00499	0	14	16										C	88885403	T	C	88885403	3	2	69	1	0	0	0	0	1	0	0	0	4998	1725	60	5	1780	5	EIF2AK3	2	88885403	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	2216163	88885403	154313970	41	21600										
SEMA4C	54910	broad.mit.edu	37	chr2	97533612	97533612	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccagcagccagacagcccaGtgtggggccatggcgcacgc	15	15	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:97533612G>A	uc002sxh.3	-	2	172	c.12C>T	c.(10-12)CAC>CAT	p.H4H	SEMA4C_uc002sxg.3_5'Flank	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	4					muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						AGACAGCCCAGTGTGGGGCCA	0.617													0	0	0	0.01441	0	61	96										A	97533612	G	A	97533612	2	1	69	1	0	0	0	0	0	0	0	1	14033	1020	36	2		2	SEMA4C	2	97533612	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	8648209	97533612	145665761	42	21601										
SULT1C4	27233	broad.mit.edu	37	chr2	108998923	108998923	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttgctgccaccatccttgctAgagaaaaactgtaaggtaaa	8	9	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:108998923A>T	uc002tea.1	+	3	751	c.378A>T	c.(376-378)CTA>CTT	p.L126L	SULT1C4_uc002tdz.2_3'UTR|SULT1C4_uc010ywr.1_Intron|SULT1C4_uc002teb.1_Intron	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	126					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						CATCCTTGCTAGAGAAAAACT	0.403													0	0	0	0.01441	0	102	140										T	108998923	A	T	108998923	2	4	69	1	0	0	0	0	0	0	0	1	15376	407	15	5		5	SULT1C4	2	108998923	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	11465311	108998923	134200450	43	21602										
RANBP2	5903	broad.mit.edu	37	chr2	109382445	109382445	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcataaacctattgcagaagCtccttcagctttcacactgg	6	12	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:109382445C>T	uc002tem.3	+	20	5576	c.5450C>T	c.(5449-5451)GCT>GTT	p.A1817V		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1817					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATTGCAGAAGCTCCTTCAGCT	0.408													0	0	0	0.001168	0	6	34										T	109382445	C	T	109382445	3	4	69	1	0	0	0	0	1	0	0	0	13028	797	28	2	5528	2	RANBP2	2	109382445	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	383522	109382445	133816928	44	21603										
ANAPC1	64682	broad.mit.edu	37	chr2	112588951	112588951	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcagacaagaactcacccacTgataaatacttggtggctca	7	11	3	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:112588951T>G	uc002thi.2	-	21	2784	c.2537A>C	c.(2536-2538)CAG>CCG	p.Q846P		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	846					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						ACTCACCCACTGATAAATACT	0.383													0	0	0	0.00278	0	19	32										G	112588951	T	G	112588951	3	3	69	1	0	0	0	0	1	0	0	0	598	1580	55	5	3409	5	ANAPC1	2	112588951	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	3206506	112588951	130610422	45	21604										
MBD5	55777	broad.mit.edu	37	chr2	149225912	149225912	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttttctctttcacatcagatGcaactccagtagtaccttct	4	12	4	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:149225912G>C	uc002twm.3	+	9	1388	c.400G>C	c.(400-402)GCA>CCA	p.A134P	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.A134P|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	134						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CACATCAGATGCAACTCCAGT	0.284													0	0	0	0.009096	0	4	5										C	149225912	G	C	149225912	3	2	69	1	0	0	0	0	1	0	0	0	9347	1319	46	4	414	4	MBD5	2	149225912	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	36636961	149225912	93973461	46	21605										
COBLL1	22837	broad.mit.edu	37	chr2	165551575	165551575	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aatcttctgtttggatggcaGtttctttcacattctcatga	7	8	5	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:165551575G>C	uc010zcw.1	-	15	2766	c.2642C>G	c.(2641-2643)ACT>AGT	p.T881S	COBLL1_uc002ucp.2_Missense_Mutation_p.T814S|COBLL1_uc002ucq.2_Missense_Mutation_p.T776S|COBLL1_uc010zcx.1_Missense_Mutation_p.T822S|COBLL1_uc002ucn.2_Missense_Mutation_p.T242S|COBLL1_uc002uco.2_Missense_Mutation_p.T545S	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	852										ovary(2)|pancreas(1)	3						TTGGATGGCAGTTTCTTTCAC	0.428													0	0	0	0.00278	0	25	30										C	165551575	G	C	165551575	3	2	69	1	0	0	0	0	1	0	0	0	3654	1029	36	4	1071	4	COBLL1	2	165551575	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	16325663	165551575	77647798	47	21606										
C2orf77	129881	broad.mit.edu	37	chr2	170505817	170505817	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cagcaattgttctttagcctCtatttttctttgtctttctt	4	9	5	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:170505817C>T	uc002ufe.2	-	8	1286	c.1192G>A	c.(1192-1194)GAG>AAG	p.E398K		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	398	Potential.										0						TCTTTAGCCTCTATTTTTCTT	0.343													0	0	0	0.00245	0	12	30										T	170505817	C	T	170505817	3	4	69	1	0	0	0	0	1	0	0	0	2194	922	32	1	474	1	C2orf77	2	170505817	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4954242	170505817	72693556	48	21607										
SLC25A12	8604	broad.mit.edu	37	chr2	172669944	172669944	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccccaacaacagagccagagCcacgctggttttgcattcgg	10	14	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:172669944C>A	uc002uhh.2	-	11	1165	c.1076G>T	c.(1075-1077)GGC>GTC	p.G359V	SLC25A12_uc010fqh.2_Missense_Mutation_p.G252V	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	359	Solcar 1.				gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	AGAGCCAGAGCCACGCTGGTT	0.443													1	0	3.10996e-30	0.01441	3.6109e-30	43	66										A	172669944	C	A	172669944	3	1	69	1	0	0	0	0	1	0	0	0	14474	739	26	4	992	4	SLC25A12	2	172669944	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2164127	172669944	70529429	49	21608										
NFE2L2	4780	broad.mit.edu	37	chr2	178098945	178098945	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	actgaagtcaaatacttctcGacttactccaagatctatat	4	10	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.010729	0	12	15										C	178098945	G	C	178098945	3	2	69	1	0	0	0	0	1	0	0	0	10368	1066	37	1	1733	1	NFE2L2	2	178098945	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	5429001	178098945	65100428	50	21609										
NIF3L1	60491	broad.mit.edu	37	chr2	201761879	201761879	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcaaccatgattgatcgaatAaaaagacacctaaaactatc	5	9	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:201761879A>G	uc002uwm.2	+	5	898	c.807A>G	c.(805-807)ATA>ATG	p.I269M	NIF3L1_uc002uwl.2_Missense_Mutation_p.I242M|NIF3L1_uc002uwn.2_Missense_Mutation_p.I242M|NIF3L1_uc002uwo.2_Missense_Mutation_p.I269M|NIF3L1_uc002uwp.2_Missense_Mutation_p.I269M|NIF3L1_uc002uwq.2_Intron	NM_001136039	NP_001129511	Q9GZT8	NIF3L_HUMAN	NIF3 NGG1 interacting factor 3-like 1 isoform 1	269					positive regulation of transcription, DNA-dependent		transcription factor binding			skin(1)	1						TTGATCGAATAAAAAGACACC	0.428													0	0	0	0.004289	0	33	45										G	201761879	A	G	201761879	3	3	69	1	0	0	0	0	1	0	0	0	10416	352	13	5	821	5	NIF3L1	2	201761879	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	23662934	201761879	41437494	51	21610										
NRP2	8828	broad.mit.edu	37	chr2	206588590	206588590	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggggatcctctccctgacctTtcacacggacatggcggtgg	13	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:206588590T>G	uc002vaw.2	+	5	1537	c.746T>G	c.(745-747)TTT>TGT	p.F249C	NRP2_uc002vat.2_Missense_Mutation_p.F249C|NRP2_uc002vau.2_Missense_Mutation_p.F249C|NRP2_uc002vav.2_Missense_Mutation_p.F249C|NRP2_uc002vax.2_Missense_Mutation_p.F249C|NRP2_uc002vay.2_Missense_Mutation_p.F249C|NRP2_uc010fud.2_Missense_Mutation_p.F249C	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	249	Extracellular (Potential).|CUB 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TCCCTGACCTTTCACACGGAC	0.552													0	0	0	0.003163	0	15	16										G	206588590	T	G	206588590	3	3	69	1	0	0	0	0	1	0	0	0	10661	1841	64	5	764	5	NRP2	2	206588590	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	4826711	206588590	36610783	52	21611										
MDH1B	130752	broad.mit.edu	37	chr2	207620047	207620047	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggaaggcctcctccaccttcGtgcagatggagacactgcgc	12	14	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:207620047G>A	uc002vbs.2	-	5	651	c.596C>T	c.(595-597)ACG>ATG	p.T199M	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.T199M|MDH1B_uc010fuj.2_Missense_Mutation_p.T101M|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	199					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		CTCCACCTTCGTGCAGATGGA	0.572													0	0	0	0.010729	0	10	29										A	207620047	G	A	207620047	3	1	69	1	0	0	0	0	1	0	0	0	9409	1145	40	2	992	2	MDH1B	2	207620047	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	1031457	207620047	35579326	53	21612										
OBSL1	23363	broad.mit.edu	37	chr2	220427307	220427307	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcgcacctctgcccagggccGgcatagctcacaggtcagca	12	16	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:220427307G>A	uc010fwk.2	-	8	2827	c.2770C>T	c.(2770-2772)CGG>TGG	p.R924W	OBSL1_uc010zli.1_5'UTR|OBSL1_uc010fwl.1_Missense_Mutation_p.R399W|OBSL1_uc002vmi.2_Missense_Mutation_p.R924W|OBSL1_uc002vmj.2_Missense_Mutation_p.R511W	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	924	Ig-like 7.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCCCAGGGCCGGCATAGCTCA	0.652													0	0	0	0.001984	0	5	22										A	220427307	G	A	220427307	3	1	69	1	0	0	0	0	1	0	0	0	10813	1115	39	2	3128	2	OBSL1	2	220427307	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	12807260	220427307	22772066	54	21613										
TRIP12	9320	broad.mit.edu	37	chr2	230650558	230650558	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctgtttcagcagctcctctCggttcacagtacgctacaaa	7	14	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:230650558C>T	uc002vpw.1	-	33	4893	c.4784G>A	c.(4783-4785)CGA>CAA	p.R1595Q	TRIP12_uc002vpx.1_Missense_Mutation_p.R1643Q|TRIP12_uc002vpy.1_Missense_Mutation_p.R1325Q	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1595					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CAGCTCCTCTCGGTTCACAGT	0.453													0	0	0	0.008871	0	20	27										T	230650558	C	T	230650558	3	4	69	1	0	0	0	0	1	0	0	0	16553	884	31	1	1230	1	TRIP12	2	230650558	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	10223251	230650558	12548815	55	21614										
COL6A3	1293	broad.mit.edu	37	chr2	238305412	238305412	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agttgtaggaaagcctgagaGaaagaggcaaaagacggcca	14	6	0	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr2:238305412G>A	uc002vwl.2	-	2	334	c.49C>T	c.(49-51)CTC>TTC	p.L17F	COL6A3_uc002vwo.2_Missense_Mutation_p.L17F|COL6A3_uc010znj.1_Missense_Mutation_p.L17F|COL6A3_uc002vwq.2_Missense_Mutation_p.L17F|COL6A3_uc002vwr.2_Missense_Mutation_p.L17F|COL6A3_uc010znk.1_Missense_Mutation_p.L17F	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	17					axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AAGCCTGAGAGAAAGAGGCAA	0.413													0	0	0	0.008291	0	9	56										A	238305412	G	A	238305412	3	1	69	1	0	0	0	0	1	0	0	0	3701	942	33	1	9703	1	COL6A3	2	238305412	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	7654854	238305412	4893961	56	21615										
SYN2	6854	broad.mit.edu	37	chr3	12211351	12211351	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cagcaagatgaaccagctgcTgtccaggactcctgccctgt	10	14	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:12211351T>C	uc003bwm.2	+	14	1417	c.1253T>C	c.(1252-1254)CTG>CCG	p.L418P	SYN2_uc003bwl.1_Missense_Mutation_p.L418P|SYN2_uc003bwn.2_Missense_Mutation_p.L92P	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	418					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						AACCAGCTGCTGTCCAGGACT	0.542													0	0	0	0.009096	0	4	15										C	12211351	T	C	12211351	3	2	69	1	0	0	0	0	1	0	0	0	15438	1580	55	5	1292	5	SYN2	3	12211351	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08		12211351	185811079	57	21616										
TTC21A	199223	broad.mit.edu	37	chr3	39180207	39180207	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctctctctgttccaggtcctCagggagcaccccgactaccc	8	18	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:39180207C>T	uc003cjc.2	+	29	4068	c.3891C>T	c.(3889-3891)CTC>CTT	p.L1297L	TTC21A_uc003cje.2_Silent_p.L1298L|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Silent_p.L1249L|TTC21A_uc003cjf.2_Silent_p.L418L	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	1297	TPR 19.						binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TCCAGGTCCTCAGGGAGCACC	0.587													0	0	0	0.01441	0	45	25										T	39180207	C	T	39180207	2	4	69	1	0	0	0	0	0	0	0	1	16684	813	29	1		1	TTC21A	3	39180207	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	26968856	39180207	158842223	58	21617										
ZNF589	51385	broad.mit.edu	37	chr3	48310197	48310197	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tatgtgcacagtgtgtgggcGaggctttcgtgaaaagtcag	15	6	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:48310197G>A	uc003csl.3	+	4	1082	c.1016G>A	c.(1015-1017)CGA>CAA	p.R339Q	ZNF589_uc010hjt.1_Missense_Mutation_p.R336Q|ZNF589_uc003csn.2_RNA|ZNF589_uc011bbg.1_Intron|ZNF589_uc003csm.2_Intron	NM_016089	NP_057173	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	339	C2H2-type 4.				regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGTGTGGGCGAGGCTTTCGT	0.502													0	0	0	0.00499	0	16	84										A	48310197	G	A	48310197	3	1	69	1	0	0	0	0	1	0	0	0	18018	1058	37	1	1030	1	ZNF589	3	48310197	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	9129990	48310197	149712233	59	21618										
COL7A1	1294	broad.mit.edu	37	chr3	48630366	48630366	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcgtggagcagaggtcgagtCatccgctgggaatgcgggat	17	8	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:48630366C>T	uc003ctz.2	-	6	689	c.688G>A	c.(688-690)GAC>AAC	p.D230N		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	230	Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GAGGTCGAGTCATCCGCTGGG	0.587													0	0	0	0.00308	0	8	15										T	48630366	C	T	48630366	3	4	69	1	0	0	0	0	1	0	0	0	3704	826	29	1	8598	1	COL7A1	3	48630366	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	320169	48630366	149392064	60	21619										
CELSR3	1951	broad.mit.edu	37	chr3	48689917	48689917	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agcctcctctgcactgccggGgggcaggcctcccacgtgga	14	16	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:48689917G>T	uc003cul.2	-	11	5985	c.5704C>A	c.(5704-5706)CCC>ACC	p.P1902T	CELSR3_uc003cuf.1_Missense_Mutation_p.P1972T|CELSR3_uc010hkg.2_5'Flank	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1902	Extracellular (Potential).|Laminin G-like 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCACTGCCGGGGGGCAGGCCT	0.637													1	0	6.42651e-13	0.010729	6.99237e-13	11	40										T	48689917	G	T	48689917	3	4	69	1	0	0	0	0	1	0	0	0	3223	1232	43	4	4334	4	CELSR3	3	48689917	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	59551	48689917	149332513	61	21620										
QARS	5859	broad.mit.edu	37	chr3	49141772	49141772	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctcaccgcttagctggggctCagtgtggatcttcttactgg	12	11	4	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:49141772C>T	uc003cvx.2	-	2	255	c.250G>A	c.(250-252)GAG>AAG	p.E84K	QARS_uc011bcd.1_5'UTR|QARS_uc003cvy.2_Intron|QARS_uc011bce.1_Intron|QARS_uc011bcf.1_Missense_Mutation_p.E84K	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	84					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGCTGGGGCTCAGTGTGGATC	0.562													0	0	0	0.01441	0	56	42										T	49141772	C	T	49141772	3	4	69	1	0	0	0	0	1	0	0	0	12871	835	29	1	2169	1	QARS	3	49141772	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	451855	49141772	148880658	62	21621										
AMT	275	broad.mit.edu	37	chr3	49459597	49459597	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cgtgtgtgcaggtgcgagtcAgtgtgactgtcccggtactg	16	9	1	1	rs151231828		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:49459597A>T	uc003cww.2	-	2	327	c.198T>A	c.(196-198)ACT>ACA	p.T66T	AMT_uc011bcn.1_Silent_p.T18T|AMT_uc003cwx.2_Silent_p.T66T|AMT_uc011bco.1_Silent_p.T66T|AMT_uc003cwy.2_Silent_p.T18T|AMT_uc011bcp.1_Intron|AMT_uc011bcq.1_Intron	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	66					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GGTGCGAGTCAGTGTGACTGT	0.607													0	0	0	0.007413	0	18	75										T	49459597	A	T	49459597	2	4	69	1	0	0	0	0	0	0	0	1	589	175	7	5		5	AMT	3	49459597	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	317825	49459597	148562833	63	21622										
PBRM1	55193	broad.mit.edu	37	chr3	52597459	52597459	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atttagcttctagcaactggAtcttcttttccagcaaaggt	7	9	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:52597459A>G	uc003des.2	-	24	3938	c.3926T>C	c.(3925-3927)ATC>ACC	p.I1309T	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.I1309T|PBRM1_uc003der.2_Missense_Mutation_p.I1277T|PBRM1_uc003det.2_Missense_Mutation_p.I1324T|PBRM1_uc003deu.2_Missense_Mutation_p.I1324T|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.I1309T|PBRM1_uc010hmk.1_Missense_Mutation_p.I1284T|PBRM1_uc003dey.2_Missense_Mutation_p.I1284T|PBRM1_uc003dez.1_Missense_Mutation_p.I1308T	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1309					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TAGCAACTGGATCTTCTTTTC	0.403			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.006122	0	16	60										G	52597459	A	G	52597459	3	3	69	1	0	0	0	0	1	0	0	0	11491	333	12	5	1002	5	PBRM1	3	52597459	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	3137862	52597459	145424971	64	21623										
FLNB	2317	broad.mit.edu	37	chr3	58111396	58111396	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	actgaaggctgccagccatcTagggtgcaagcccaaggacc	12	13	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:58111396T>C	uc003djj.2	+	23	4152	c.3987T>C	c.(3985-3987)TCT>TCC	p.S1329S	FLNB_uc010hne.2_Silent_p.S1329S|FLNB_uc003djk.2_Silent_p.S1329S|FLNB_uc010hnf.2_Silent_p.S1329S|FLNB_uc003djl.2_Silent_p.S1160S|FLNB_uc003djm.2_Silent_p.S1160S	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1329	Filamin 12.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GCCAGCCATCTAGGGTGCAAG	0.522													0	0	0	0.01441	0	54	44										C	58111396	T	C	58111396	2	2	69	1	0	0	0	0	0	0	0	1	5934	1509	53	5		5	FLNB	3	58111396	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	5513937	58111396	139911034	65	21624										
DZIP3	9666	broad.mit.edu	37	chr3	108407451	108407451	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tattttcagagtcaaggaaaAtcagtgtcaaatgttaattg	8	4	4	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:108407451A>G	uc003dxd.2	+	30	3704	c.3282A>G	c.(3280-3282)AAA>AAG	p.K1094K	DZIP3_uc003dxf.1_Silent_p.K1094K|DZIP3_uc011bhm.1_Silent_p.K545K	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	1094					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTCAAGGAAAATCAGTGTCAA	0.403													0	0	0	0.006122	0	19	24										G	108407451	A	G	108407451	2	3	69	1	0	0	0	0	0	0	0	1	4865	98	4	5		5	DZIP3	3	108407451	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	50296055	108407451	89614979	66	21625										
SEMA5B	54437	broad.mit.edu	37	chr3	122631022	122631022	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cgggatgtgcctcatacctgGgcaggcctgtgtggcacata	14	11	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:122631022G>A	uc003efz.1	-	19	3197	c.2893C>T	c.(2893-2895)CCA>TCA	p.P965S	SEMA5B_uc011bju.1_Missense_Mutation_p.P871S|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.P965S|SEMA5B_uc003efy.1_Intron	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	965	Extracellular (Potential).|TSP type-1 4.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CTCATACCTGGGCAGGCCTGT	0.642													0	0	0	0.010729	0	11	13										A	122631022	G	A	122631022	3	1	69	1	0	0	0	0	1	0	0	0	14038	1232	43	2	582	2	SEMA5B	3	122631022	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	14223571	122631022	75391408	67	21626										
RAB43	339122	broad.mit.edu	37	chr3	128852989	128852989	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcttccttttctcctcttgcCagccgagcctctctctctgc	5	18	5	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:128852989C>T	uc003elo.1	-	9	802	c.591G>A	c.(589-591)CTG>CTA	p.L197L	ISY1_uc010hsz.1_Intron|ISY1_uc003elp.1_Silent_p.L197L|ISY1_uc010hta.1_Silent_p.L219L	NM_020701	NP_065752	Q86YS6	RAB43_HUMAN	ISY1 splicing factor homolog	Error:Variant_position_missing_in_Q86YS6_after_alignment					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1						CTCCTCTTGCCAGCCGAGCCT	0.428													0	0	0	0.001855	0	11	88										T	128852989	C	T	128852989	2	4	69	1	0	0	0	0	0	0	0	1	12945	581	21	2		2	RAB43	3	128852989	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	6221967	128852989	69169441	68	21627										
NAALADL2	254827	broad.mit.edu	37	chr3	175184817	175184817	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acactgcacacagttataatGgacaagaatgggccagtagt	10	8	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:175184817G>A	uc003fit.2	+	8	1465	c.1378G>A	c.(1378-1380)GGA>AGA	p.G460R	NAALADL2_uc003fiu.1_Missense_Mutation_p.G453R|NAALADL2_uc010hwy.1_Missense_Mutation_p.G234R|NAALADL2_uc010hwz.1_Missense_Mutation_p.G54R	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	460	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CAGTTATAATGGACAAGAATG	0.403													0	0	0	0.01441	0	61	142										A	175184817	G	A	175184817	3	1	69	1	0	0	0	0	1	0	0	0	10130	1349	47	2	1408	2	NAALADL2	3	175184817	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	46331828	175184817	22837613	69	21628										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.001984	0	7	13										A	178936091	G	A	178936091	3	1	69	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3751274	178936091	19086339	70	21629										
MFN1	55669	broad.mit.edu	37	chr3	179085314	179085314	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tagaagcacagaatcgtatcTtctttgtttcagcaaaggaa	8	7	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:179085314T>G	uc003fjs.2	+	8	967	c.841T>G	c.(841-843)TTC>GTC	p.F281V	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.F309V|MFN1_uc010hxc.2_Missense_Mutation_p.F134V	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	281	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GAATCGTATCTTCTTTGTTTC	0.403													0	0	0	0.008361	0	30	18										G	179085314	T	G	179085314	3	3	69	1	0	0	0	0	1	0	0	0	9523	1609	56	5	867	5	MFN1	3	179085314	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	149223	179085314	18937116	71	21630										
FGF12	2257	broad.mit.edu	37	chr3	191888334	191888334	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttgaccttctttattgagtcCcagaaaccaagctcggcctg	8	12	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr3:191888334C>A	uc003fsx.2	-	4	1352	c.526G>T	c.(526-528)GGA>TGA	p.G176*	FGF12_uc003fsy.2_Nonsense_Mutation_p.G114*	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	176					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTATTGAGTCCCAGAAACCAA	0.413													1	0	1.45844e-13	0.013726	1.60196e-13	31	137										A	191888334	C	A	191888334	4	1	69	1	0	0	0	0	0	1	0	0	5841	632	22	4	213	4	FGF12	3	191888334	Nonsense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	12803020	191888334	6134096	72	21631										
PIGG	54872	broad.mit.edu	37	chr4	509942	509942	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tacagtgcagcttagtaaacTgttgcaagagaatgtgccgt	11	7	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:509942T>A	uc003gak.3	+	6	1218	c.1082T>A	c.(1081-1083)CTG>CAG	p.L361Q	PIGG_uc003gaj.3_Missense_Mutation_p.L361Q|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.L228Q|PIGG_uc003gal.3_Missense_Mutation_p.L272Q|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.L239Q|PIGG_uc003gam.2_Missense_Mutation_p.L272Q|PIGG_uc003gan.2_Missense_Mutation_p.L272Q	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	361	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CTTAGTAAACTGTTGCAAGAG	0.453													0	0	0	0.00874	0	42	55										A	509942	T	A	509942	3	1	69	1	0	0	0	0	1	0	0	0	11888	1580	55	5	1104	5	PIGG	4	509942	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08		509942	190644334	73	21632										
DGKQ	1609	broad.mit.edu	37	chr4	955317	955317	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtcgtccatgcgtggcttctCaaacctggtgtcgctgtcgg	13	12	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:955317C>T	uc003gbw.2	-	21	2586	c.2512G>A	c.(2512-2514)GAG>AAG	p.E838K	DGKQ_uc010ibn.2_Missense_Mutation_p.E825K	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	838					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGTGGCTTCTCAAACCTGGTG	0.701													0	0	0	0.008291	0	9	12										T	955317	C	T	955317	3	4	69	1	0	0	0	0	1	0	0	0	4473	835	29	1	328	1	DGKQ	4	955317	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	445375	955317	190198959	74	21633										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.004007	0	10	17										G	1803568	C	G	1803568	3	3	69	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	848251	1803568	189350708	75	21634										
JAKMIP1	152789	broad.mit.edu	37	chr4	6114541	6114541	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	caccgcgtccgtctccatctCgggcttctcgcccttgctcc	8	20	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:6114541C>T	uc003giu.3	-	2	313	c.37G>A	c.(37-39)GAG>AAG	p.E13K	JAKMIP1_uc010idb.1_Missense_Mutation_p.E13K|JAKMIP1_uc010idc.1_Missense_Mutation_p.E13K|JAKMIP1_uc010idd.1_Missense_Mutation_p.E13K|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E13K|JAKMIP1_uc003giv.3_Missense_Mutation_p.E13K|JAKMIP1_uc010ide.2_Missense_Mutation_p.E13K	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	13	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GTCTCCATCTCGGGCTTCTCG	0.612													0	0	0	0.00278	0	22	62										T	6114541	C	T	6114541	3	4	69	1	0	0	0	0	1	0	0	0	7940	893	31	1	2613	1	JAKMIP1	4	6114541	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4310973	6114541	185039735	76	21635										
NCAPG	64151	broad.mit.edu	37	chr4	17816575	17816575	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gactttgccaaaaattgtagGgcgcaccaaggatgtgaaag	12	7	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:17816575G>T	uc003gpp.2	+	4	820	c.644G>T	c.(643-645)GGG>GTG	p.G215V	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	215					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		AAAATTGTAGGGCGCACCAAG	0.403													1	0	4.00102e-26	0.00623	4.59918e-26	36	47										T	17816575	G	T	17816575	3	4	69	1	0	0	0	0	1	0	0	0	10207	1232	43	4	658	4	NCAPG	4	17816575	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	11702034	17816575	173337701	77	21636										
KDR	3791	broad.mit.edu	37	chr4	55970921	55970921	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgcattcttaagctccatgaTcaaaatgtcatttgtgctat	6	8	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:55970921T>C	uc003has.2	-	13	2178	c.1876A>G	c.(1876-1878)ATC>GTC	p.I626V	KDR_uc003hat.1_Missense_Mutation_p.I626V|KDR_uc011bzx.1_Missense_Mutation_p.I626V	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	626	Ig-like C2-type 6.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGCTCCATGATCAAAATGTCA	0.448			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.004672	0	3	25										C	55970921	T	C	55970921	3	2	69	1	0	0	0	0	1	0	0	0	8139	1435	50	5	2266	5	KDR	4	55970921	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	38154346	55970921	135183355	78	21637										
PROL1	58503	broad.mit.edu	37	chr4	71275374	71275374	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaacctacatttcccactaaGaccttactatgtaggaccta	4	12	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:71275374G>C	uc003hfi.2	+	3	503	c.329G>C	c.(328-330)AGA>ACA	p.R110T		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	110	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				TTCCCACTAAGACCTTACTAT	0.403													0	0	0	0.010818	0	26	120										C	71275374	G	C	71275374	3	2	69	1	0	0	0	0	1	0	0	0	12554	942	33	1	335	1	PROL1	4	71275374	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	15304453	71275374	119878902	79	21638										
ADAMTS3	9508	broad.mit.edu	37	chr4	73186565	73186565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccaagcttctggatgggtttCccctttctatgaggctgatg	11	10	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:73186565C>T	uc003hgk.1	-	7	1005	c.968G>A	c.(967-969)GGA>GAA	p.G323E		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	323	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGATGGGTTTCCCCTTTCTAT	0.428													0	0	0	0.001168	0	5	16										T	73186565	C	T	73186565	3	4	69	1	0	0	0	0	1	0	0	0	267	855	30	1	2713	1	ADAMTS3	4	73186565	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1911191	73186565	117967711	80	21639										
RASGEF1B	153020	broad.mit.edu	37	chr4	82362031	82362031	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttaaagacctttgtgctgccCcacgaagagctgttcgataa	9	10	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:82362031C>T	uc003hmi.1	-	10	1205	c.1061G>A	c.(1060-1062)GGG>GAG	p.G354E	RASGEF1B_uc003hmj.1_Missense_Mutation_p.G353E|RASGEF1B_uc010ijq.1_Missense_Mutation_p.G312E	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	354	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						TTGTGCTGCCCCACGAAGAGC	0.338													0	0	0	0.01441	0	43	56										T	82362031	C	T	82362031	3	4	69	1	0	0	0	0	1	0	0	0	13070	623	22	2	380	2	RASGEF1B	4	82362031	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	9175466	82362031	108792245	81	21640										
HERC6	55008	broad.mit.edu	37	chr4	89300153	89300161	+	In_Frame_Del	DEL	AGGCGGCCA	AGGCGGCCA	-													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccccggggctgagctactgcAggcggccagcggggagcgcc							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:89300153_89300161delAGGCGGCCA	uc011cdi.1	+	1	263_271	c.80_88delAGGCGGCCA	c.(79-90)CAGGCGGCCAGC>CGC	p.27_30QAAS>R	HERC6_uc003hrp.1_RNA|HERC6_uc011cdj.1_In_Frame_Del_p.27_30QAAS>R|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	27_30					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GAGCTACTGCAGGCGGCCAGCGGGGAGCG	0.722																		7	10	---	---								-	89300161	AGGCGGCCA	-	89300153	7	5	69	1	0	1	0	1	0	0	0	0	7062	188	7	0		0	HERC6	4	89300153	In_Frame_Del	DEL	AGGCGGCCA	TCGA-E5-A2PC-01A-11D-A202-08	6938122	89300153	101854123	82	21641										
GAR1	54433	broad.mit.edu	37	chr4	110740212	110740212	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttcatcctttaaaaaactacAgaaggtgagtcaaacttatg	6	7	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:110740212A>T	uc003hzt.2	+	4	732	c.425A>T	c.(424-426)CAG>CTG	p.Q142L	GAR1_uc003hzu.2_Missense_Mutation_p.Q142L|GAR1_uc010imh.1_Missense_Mutation_p.Q142L|GAR1_uc010imi.2_Missense_Mutation_p.Q142L	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	142					rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						AAAAAACTACAGAAGGTGAGT	0.343													0	0	0	0.013726	0	30	40										T	110740212	A	T	110740212	3	4	69	1	0	0	0	0	1	0	0	0	6240	188	7	5	435	5	GAR1	4	110740212	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	21440059	110740212	80414064	83	21642										
LRIT3	345193	broad.mit.edu	37	chr4	110789062	110789062	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggcttccccaccccacagatCacatggaccagatctgacag	8	16	2	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr4:110789062C>A	uc003hzx.3	+	2	913	c.720C>A	c.(718-720)ATC>ATA	p.I240I	LRIT3_uc003hzw.3_Silent_p.I102I	NM_198506	NP_940908	Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and	240	Ig-like.					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		CCCCACAGATCACATGGACCA	0.453													1	0	0.00198382	0.001984	0.00203077	5	37										A	110789062	C	A	110789062	2	1	69	1	0	0	0	0	0	0	0	1	8949	816	29	3		3	LRIT3	4	110789062	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	48850	110789062	80365214	84	21643										
SLC9A3	6550	broad.mit.edu	37	chr5	476428	476428	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttccgcatggtcctgtggaaGatttcccggtcctgtttctc	10	12	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:476428G>A	uc003jbe.2	-	13	2068	c.1956C>T	c.(1954-1956)ATC>ATT	p.I652I	SLC9A3_uc011clx.1_Silent_p.I643I|uc011cly.1_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	652	Interaction with PDZD3 (By similarity).|Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TCCTGTGGAAGATTTCCCGGT	0.607													0	0	0	0.01441	0	64	19										A	476428	G	A	476428	2	1	69	1	0	0	0	0	0	0	0	1	14713	932	33	1		1	SLC9A3	5	476428	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		476428	180438832	85	21644										
CTNND2	1501	broad.mit.edu	37	chr5	11022943	11022943	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccaccggcatcccgtaaggcCttggcgttctccatgttctt	9	15	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:11022943C>T	uc003jfa.1	-	17	3082	c.2937G>A	c.(2935-2937)AAG>AAA	p.K979K	CTNND2_uc010itt.2_Silent_p.K888K|CTNND2_uc011cmy.1_Silent_p.K642K|CTNND2_uc011cmz.1_Silent_p.K546K|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.K571K	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	979	ARM 9.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CCCGTAAGGCCTTGGCGTTCT	0.512													0	0	0	0.008291	0	9	28										T	11022943	C	T	11022943	2	4	69	1	0	0	0	0	0	0	0	1	4020	680	24	2		2	CTNND2	5	11022943	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	10546515	11022943	169892317	86	21645										
HCN1	348980	broad.mit.edu	37	chr5	45645317	45645317	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgatgtatgtatctaattaaCcttgaaagtcgtaataaacg	7	5	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:45645317C>A	uc003jok.2	-	2	844	c.819G>T	c.(817-819)AGG>AGT	p.R273S		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	273	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						ATCTAATTAACCTTGAAAGTC	0.328													1	0	0.00116845	0.001168	0.00119965	6	2										A	45645317	C	A	45645317	3	1	69	1	0	0	0	0	1	0	0	0	6996	506	18	4	1881	4	HCN1	5	45645317	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	34622374	45645317	135269943	87	21646										
PLK2	10769	broad.mit.edu	37	chr5	57755666	57755666	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggactgaggtggctgcgattCctcggggggctgcggcggcc	20	11	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:57755666C>T	uc003jrn.2	-	1	248	c.121G>A	c.(121-123)GAA>AAA	p.E41K	PLK2_uc011cql.1_5'Flank	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	41					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		GGCTGCGATTCCTCGGGGGGC	0.677													0	0	0	0.008871	0	19	7										T	57755666	C	T	57755666	3	4	69	1	0	0	0	0	1	0	0	0	12096	864	30	1	1992	1	PLK2	5	57755666	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	12110349	57755666	123159594	88	21647										
C5orf44	80006	broad.mit.edu	37	chr5	64920912	64920912	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aagtgaatccccctaaacagGagcacctgctggcgctaaaa	9	12	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:64920912G>C	uc003jtz.3	+	1	355	c.25G>C	c.(25-27)GAG>CAG	p.E9Q	TRIM23_uc003jtw.2_5'Flank|TRIM23_uc003jtx.2_5'Flank|TRIM23_uc003jty.2_5'Flank|C5orf44_uc010iwu.1_5'UTR|C5orf44_uc003jua.3_Missense_Mutation_p.E9Q|C5orf44_uc003juc.3_Missense_Mutation_p.E9Q|C5orf44_uc010iwv.2_Missense_Mutation_p.E9Q	NM_024941	NP_079217	A5PLN9	CE044_HUMAN	hypothetical protein LOC80006 isoform 2	9										ovary(1)	1						CCCTAAACAGGAGCACCTGCT	0.512													0	0	0	0.00499	0	14	7										C	64920912	G	C	64920912	3	2	69	1	0	0	0	0	1	0	0	0	2303	1175	41	1	27	1	C5orf44	5	64920912	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	7165246	64920912	115994348	89	21648										
CAST	831	broad.mit.edu	37	chr5	96100940	96100940	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttcagcagagtgacaaagacCtcgatgatgccttggataaa	10	8	1	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:96100940C>A	uc003klz.1	+	24	1861	c.1699C>A	c.(1699-1701)CTC>ATC	p.L567I	CAST_uc003klt.2_Missense_Mutation_p.L554I|CAST_uc003klu.2_Missense_Mutation_p.L650I|CAST_uc003klv.2_Missense_Mutation_p.L628I|CAST_uc003klw.2_Missense_Mutation_p.L631I|CAST_uc003klx.2_Missense_Mutation_p.L609I|CAST_uc003kly.2_Missense_Mutation_p.L615I|CAST_uc011cuo.1_Missense_Mutation_p.L613I|CAST_uc011cur.1_Missense_Mutation_p.L553I|CAST_uc011cus.1_Missense_Mutation_p.L554I|CAST_uc003kma.1_Missense_Mutation_p.L525I|CAST_uc011cut.1_Missense_Mutation_p.L495I|CAST_uc003kmb.2_Missense_Mutation_p.L513I|CAST_uc003kmc.2_Missense_Mutation_p.L567I|CAST_uc003kmd.2_Missense_Mutation_p.L545I|CAST_uc003kme.2_Missense_Mutation_p.L526I|CAST_uc003kmf.2_Missense_Mutation_p.L532I|CAST_uc003kmh.2_Missense_Mutation_p.L281I|CAST_uc010jbj.2_Missense_Mutation_p.L282I|CAST_uc010jbk.2_Missense_Mutation_p.L282I|CAST_uc010jbl.1_Missense_Mutation_p.L290I|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.L289I|CAST_uc003kmk.2_RNA|ERAP1_uc003kml.2_Intron	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	567							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		TGACAAAGACCTCGATGATGC	0.403													1	0	1.15088e-07	0.004007	1.22902e-07	17	8										A	96100940	C	A	96100940	3	1	69	1	0	0	0	0	1	0	0	0	2684	681	24	4	2174	4	CAST	5	96100940	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	31180028	96100940	84814320	90	21649										
PCDHA6	56142	broad.mit.edu	37	chr5	140209959	140209959	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cggcagagggtgtgctccggGgagggcccacccaagatgga	18	11	0	2	rs150255684	byFrequency	TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:140209959G>A	uc003lho.2	+	1	2310	c.2283G>A	c.(2281-2283)GGG>GGA	p.G761G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.G761G	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	761	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTCCGGGGAGGGCCCAC	0.607													0	0	0	0.008291	0	11	44										A	140209959	G	A	140209959	2	1	69	1	0	0	0	0	0	0	0	1	11528	1219	43	2		2	PCDHA6	5	140209959	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	44109019	140209959	40705301	91	21650										
FAT2	2196	broad.mit.edu	37	chr5	150946090	150946090	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	actgtcagcagcttccaggaGgacttctggggtgtgcccag	14	11	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:150946090G>A	uc003lue.3	-	1	2416	c.2403C>T	c.(2401-2403)TCC>TCT	p.S801S	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.S801S	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	801	Extracellular (Potential).|Cadherin 6.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCCAGGAGGACTTCTGGG	0.512													0	0	0	0.01441	0	46	10										A	150946090	G	A	150946090	2	1	69	1	0	0	0	0	0	0	0	1	5690	987	35	2		2	FAT2	5	150946090	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	10736131	150946090	29969170	92	21651										
DOCK2	1794	broad.mit.edu	37	chr5	169477279	169477279	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gaacaaagtgttcatctaccGcgggaaggaatatgagcgaa	12	7	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:169477279G>T	uc003maf.2	+	41	4171	c.4091G>T	c.(4090-4092)CGC>CTC	p.R1364L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R856L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1364	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCATCTACCGCGGGAAGGAA	0.502													1	0	1.42033e-22	0.004289	1.606e-22	35	70										T	169477279	G	T	169477279	3	4	69	1	0	0	0	0	1	0	0	0	4687	1087	38	4	4253	4	DOCK2	5	169477279	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	18531189	169477279	11437981	93	21652										
TMED9	54732	broad.mit.edu	37	chr5	177019252	177019268	+	Frame_Shift_Del	DEL	CGGCCCGGAACCGGGCT	CGGCCCGGAACCGGGCT	-													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcgtgctgctcgtccggcccCggcccggaaccgggctgggt					rs57960711	byFrequency	TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr5:177019252_177019268delCGGCCCGGAACCGGGCT	uc003mhx.2	+	1	40_56	c.37_53delCGGCCCGGAACCGGGCT	c.(37-54)CGGCCCGGAACCGGGCTGfs	p.R13fs	TMED9_uc010jko.2_RNA	NM_017510	NP_059980	Q9BVK6	TMED9_HUMAN	transmembrane emp24 protein transport domain	13_18					transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane					0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGTCCGGCCCCGGCCCGGAACCGGGCTGGGTAGAGTG	0.696																		10	10	---	---								-	177019268	CGGCCCGGAACCGGGCT	-	177019252	7	5	69	1	0	1	0	1	0	0	0	0	16009	643	23	0	39	0	TMED9	5	177019252	Frame_Shift_Del	DEL	CGGCCCGGAACCGGGCT	TCGA-E5-A2PC-01A-11D-A202-08	7541973	177019252	3896008	94	21653										
SLC22A23	63027	broad.mit.edu	37	chr6	3284172	3284172	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aacatgcccacgatggaaaaCgcgatggaaaatttgtcctt	9	9	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:3284172C>A	uc003mvm.3	-	9	1617	c.1617G>T	c.(1615-1617)GCG>GCT	p.A539A	uc003mvi.1_Intron|SLC22A23_uc003mvn.3_Silent_p.A258A|SLC22A23_uc003mvo.3_Silent_p.A258A|SLC22A23_uc003mvp.1_RNA|SLC22A23_uc010jnn.2_Silent_p.A539A	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	539	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				CGATGGAAAACGCGATGGAAA	0.587													1	0	9.31168e-06	0.001855	9.73366e-06	14	22										A	3284172	C	A	3284172	2	1	69	1	0	0	0	0	0	0	0	1	14452	523	19	4		4	SLC22A23	6	3284172	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08		3284172	167830895	95	21654										
RREB1	6239	broad.mit.edu	37	chr6	7230402	7230402	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccgcgctcatccgccacctGcgcacgcacagtggggagcg	14	17	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:7230402G>T	uc003mxc.2	+	10	2460	c.2070G>T	c.(2068-2070)CTG>CTT	p.L690L	RREB1_uc003mxb.2_Silent_p.L690L|RREB1_uc010jnx.2_Silent_p.L690L	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	690	C2H2-type 8.				multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TCCGCCACCTGCGCACGCACA	0.627													1	0	8.60227e-14	0.004007	9.47894e-14	17	39										T	7230402	G	T	7230402	2	4	69	1	0	0	0	0	0	0	0	1	13679	1306	46	4		4	RREB1	6	7230402	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3946230	7230402	163884665	96	21655										
TRERF1	55809	broad.mit.edu	37	chr6	42231063	42231063	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gagggtcatcctcacgagcaCaggcatctcgtcgtccgaca	11	14	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:42231063C>G	uc003osd.2	-	8	2442	c.1879G>C	c.(1879-1881)GTG>CTG	p.V627L	TRERF1_uc011duq.1_Intron|TRERF1_uc003osb.2_Intron|TRERF1_uc003osc.2_Intron|TRERF1_uc003ose.2_Missense_Mutation_p.V627L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	627	Pro-rich.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTCACGAGCACAGGCATCTCG	0.682													0	0	0	0.003755	0	31	80										G	42231063	C	G	42231063	3	3	69	1	0	0	0	0	1	0	0	0	16472	478	17	4	1767	4	TRERF1	6	42231063	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	35000661	42231063	128884004	97	21656										
UBR2	23304	broad.mit.edu	37	chr6	42625826	42625826	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctggaaacactacaaaatgcTccctacctagaagtccacaa	5	13	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:42625826T>G	uc011dur.1	+	27	2937	c.2937T>G	c.(2935-2937)GCT>GCG	p.A979A	UBR2_uc011dus.1_Silent_p.A624A|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	979					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			TACAAAATGCTCCCTACCTAG	0.373													0	0	0	0.01441	0	56	73										G	42625826	T	G	42625826	2	3	69	1	0	0	0	0	0	0	0	1	16899	1538	54	5		5	UBR2	6	42625826	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	394763	42625826	128489241	98	21657										
CUL7	9820	broad.mit.edu	37	chr6	43008026	43008026	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	caggacaagcacagacacttCtggcattgccccttcatagt	8	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:43008026C>T	uc003otq.2	-	22	4465	c.4162G>A	c.(4162-4164)GAA>AAA	p.E1388K	CUL7_uc010jyg.2_Missense_Mutation_p.E667K|CUL7_uc011dvb.1_Missense_Mutation_p.E1472K|CUL7_uc010jyh.2_Missense_Mutation_p.E381K|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1388					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ACAGACACTTCTGGCATTGCC	0.498													0	0	0	0.008361	0	32	42										T	43008026	C	T	43008026	3	4	69	1	0	0	0	0	1	0	0	0	4060	922	32	1	954	1	CUL7	6	43008026	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	382200	43008026	128107041	99	21658										
TDRD6	221400	broad.mit.edu	37	chr6	46656613	46656613	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atccccagctgcagctgggcGtgacggaggccgtggtcata	15	12	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:46656613G>A	uc003oyj.2	+	1	748	c.748G>A	c.(748-750)GTG>ATG	p.V250M	TDRD6_uc010jze.2_Missense_Mutation_p.V244M	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	250					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GCAGCTGGGCGTGACGGAGGC	0.632													0	0	0	0.007413	0	20	22										A	46656613	G	A	46656613	3	1	69	1	0	0	0	0	1	0	0	0	15731	1145	40	2	750	2	TDRD6	6	46656613	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3648587	46656613	124458454	100	21659										
TDRD6	221400	broad.mit.edu	37	chr6	46661470	46661470	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tggatgaagaaaaaggggagCtaagcccggtgccaccgaat	14	8	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:46661470C>G	uc003oyj.2	+	1	5605	c.5605C>G	c.(5605-5607)CTA>GTA	p.L1869V	TDRD6_uc010jze.2_Missense_Mutation_p.L1863V	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1869					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AAAAGGGGAGCTAAGCCCGGT	0.478													0	0	0	0.00308	0	8	43										G	46661470	C	G	46661470	3	3	69	1	0	0	0	0	1	0	0	0	15731	796	28	4	5607	4	TDRD6	6	46661470	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4857	46661470	124453597	101	21660										
AKD1	221264	broad.mit.edu	37	chr6	109854548	109854548	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	caatttgggcaggaaggaggCgatcaaaaatatcttgatca	11	6	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:109854548C>A	uc003ptn.2	-	28	3553	c.3476G>T	c.(3475-3477)CGC>CTC	p.R1159L	AKD1_uc011eat.1_Missense_Mutation_p.R238L	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1159					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGGAAGGAGGCGATCAAAAAT	0.383													1	0	0.004672	0.004672	0.00475445	3	15										A	109854548	C	A	109854548	3	1	69	1	0	0	0	0	1	0	0	0	460	768	27	4	2315	4	AKD1	6	109854548	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	63193078	109854548	61260519	102	21661										
CLVS2	134829	broad.mit.edu	37	chr6	123319132	123319132	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	catcactttgaggccttccgCctcctggcgcagtactttga	9	14	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:123319132C>G	uc003pzi.1	+	2	1079	c.210C>G	c.(208-210)CGC>CGG	p.R70R		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	70					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						AGGCCTTCCGCCTCCTGGCGC	0.547													0	0	0	0.013726	0	28	51										G	123319132	C	G	123319132	2	3	69	1	0	0	0	0	0	0	0	1	3572	726	26	4		4	CLVS2	6	123319132	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	13464584	123319132	47795935	103	21662										
UTRN	7402	broad.mit.edu	37	chr6	144613024	144613024	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gggcagaacgaattcagtgaTatcattaagtccagatctgg	11	7	3	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:144613024T>C	uc003qkt.2	+	1	152	c.60T>C	c.(58-60)GAT>GAC	p.D20D	UTRN_uc010khq.1_Silent_p.D20D	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	20	Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AATTCAGTGATATCATTAAGT	0.378													0	0	0	0.010504	0	19	11										C	144613024	T	C	144613024	2	2	69	1	0	0	0	0	0	0	0	1	17100	1403	49	5		5	UTRN	6	144613024	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	21293892	144613024	26502043	104	21663										
ZBTB2	57621	broad.mit.edu	37	chr6	151687920	151687920	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acttgatgccctgttctaatCgaaccgggtcgatgagctga	11	10	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:151687920C>T	uc003qoh.2	-	3	416	c.281G>A	c.(280-282)CGA>CAA	p.R94Q		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		CTGTTCTAATCGAACCGGGTC	0.537													0	0	0	0.01441	0	59	18										T	151687920	C	T	151687920	3	4	69	1	0	0	0	0	1	0	0	0	17525	884	31	1	1267	1	ZBTB2	6	151687920	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	7074896	151687920	19427147	105	21664										
WTAP	9589	broad.mit.edu	37	chr6	160169296	160169296	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atcaacaatggtagacccagCgatcaacttgtttttcctaa	6	10	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:160169296C>T	uc003qsl.2	+	6	569	c.347C>T	c.(346-348)GCG>GTG	p.A116V	WTAP_uc010kjx.2_Missense_Mutation_p.A116V|WTAP_uc003qsk.2_Missense_Mutation_p.A116V|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Missense_Mutation_p.A116V	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	116					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GTAGACCCAGCGATCAACTTG	0.443													0	0	0	0.008291	0	11	8										T	160169296	C	T	160169296	3	4	69	1	0	0	0	0	1	0	0	0	17406	768	27	2	365	2	WTAP	6	160169296	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	8481376	160169296	10945771	106	21665										
TTLL2	83887	broad.mit.edu	37	chr6	167755014	167755014	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aagacctccccgtgtgtcctGtcagaccgtggcaaagctcc	10	15	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr6:167755014G>C	uc003qvs.1	+	3	1714	c.1626G>C	c.(1624-1626)CTG>CTC	p.L542L	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	542					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGTGTGTCCTGTCAGACCGTG	0.532													0	0	0	0.004289	0	32	14										C	167755014	G	C	167755014	2	2	69	1	0	0	0	0	0	0	0	1	16724	1364	48	4		4	TTLL2	6	167755014	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	7585718	167755014	3360053	107	21666										
PRKAR1B	5575	broad.mit.edu	37	chr7	624145	624145	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcaggggcgcagccactgacCtaggatggagaccttgctga	15	11	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:624145C>G	uc003siu.1	-	9	875	c.769G>C	c.(769-771)GAG>CAG	p.E257Q	PRKAR1B_uc003siv.2_Missense_Mutation_p.E257Q|PRKAR1B_uc003siw.1_Missense_Mutation_p.E257Q|PRKAR1B_uc003six.1_RNA	NM_002735	NP_002726	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type	257	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		AGCCACTGACCTAGGATGGAG	0.592													0	0	0	0.008291	0	10	17										G	624145	C	G	624145	3	3	69	1	0	0	0	0	1	0	0	0	12504	695	24	4	392	4	PRKAR1B	7	624145	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08		624145	158514518	108	21667										
IGF2BP3	10643	broad.mit.edu	37	chr7	23390927	23390927	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acactcagcatactcacttaGactgggtctgtttggtgatg	10	9	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:23390927G>C	uc003swg.2	-	6	946	c.680C>G	c.(679-681)TCT>TGT	p.S227C		NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	227	KH 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						TACTCACTTAGACTGGGTCTG	0.488													0	0	0	0.006122	0	17	60										C	23390927	G	C	23390927	3	2	69	1	0	0	0	0	1	0	0	0	7575	942	33	1	1099	1	IGF2BP3	7	23390927	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	22766782	23390927	135747736	109	21668										
OSBPL3	26031	broad.mit.edu	37	chr7	24911680	24911680	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctcagtccttccaccacttcCcagctgtcctgttccaacaa	4	18	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:24911680C>G	uc003sxf.2	-	3	510	c.105G>C	c.(103-105)TGG>TGC	p.W35C	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.W35C|OSBPL3_uc003sxh.2_Missense_Mutation_p.W35C|OSBPL3_uc003sxi.2_Missense_Mutation_p.W35C	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	35					lipid transport		lipid binding|protein binding			skin(1)	1						CCACCACTTCCCAGCTGTCCT	0.403													0	0	0	0.003163	0	12	37										G	24911680	C	G	24911680	3	3	69	1	0	0	0	0	1	0	0	0	11279	624	22	4	2642	4	OSBPL3	7	24911680	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1520753	24911680	134226983	110	21669										
EGFR	1956	broad.mit.edu	37	chr7	55224469	55224469	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cagtgactccttcacacataCtcctcctctggatccacagg	6	16	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:55224469C>G	uc003tqk.2	+	10	1397	c.1151C>G	c.(1150-1152)ACT>AGT	p.T384S	EGFR_uc003tqh.2_Missense_Mutation_p.T384S|EGFR_uc003tqi.2_Missense_Mutation_p.T384S|EGFR_uc003tqj.2_Missense_Mutation_p.T384S|EGFR_uc010kzg.1_Missense_Mutation_p.T339S|EGFR_uc011kco.1_Missense_Mutation_p.T331S|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	384	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTCACACATACTCCTCCTCTG	0.373		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			0	0	0	0.007413	0	18	85										G	55224469	C	G	55224469	3	3	69	1	0	0	0	0	1	0	0	0	4967	565	20	4	1189	4	EGFR	7	55224469	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	30312789	55224469	103914194	111	21670										
LANCL2	55915	broad.mit.edu	37	chr7	55468950	55468950	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgcccgctgttgtaccagtgGcaccggaagcagtacgttgg	14	11	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:55468950G>C	uc003tqp.2	+	5	1340	c.762G>C	c.(760-762)TGG>TGC	p.W254C		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	254					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGTACCAGTGGCACCGGAAGC	0.438													0	0	0	0.01441	0	45	55										C	55468950	G	C	55468950	3	2	69	1	0	0	0	0	1	0	0	0	8621	1212	42	4	780	4	LANCL2	7	55468950	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	244481	55468950	103669713	112	21671										
GNAI1	2770	broad.mit.edu	37	chr7	79846687	79846687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aagacctcaataaaagaaagGacacaaaggaaatatacacc	6	8	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:79846687G>A	uc003uhb.1	+	8	1280	c.943G>A	c.(943-945)GAC>AAC	p.D315N	GNAI1_uc011kgt.1_Missense_Mutation_p.D263N	NM_002069	NP_002060	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein),	315					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TAAAAGAAAGGACACAAAGGA	0.348													0	0	0	0.013537	0	12	24										A	79846687	G	A	79846687	3	1	69	1	0	0	0	0	1	0	0	0	6504	1174	41	1	973	1	GNAI1	7	79846687	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	24377737	79846687	79291976	113	21672										
MUC17	140453	broad.mit.edu	37	chr7	100685857	100685857	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctttcaacaccttctgttgtCaccagcacacctgtgaccac	5	16	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:100685857C>G	uc003uxp.1	+	3	11213	c.11160C>G	c.(11158-11160)GTC>GTG	p.V3720V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3720	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTTCTGTTGTCACCAGCACAC	0.507													0	0	0	0.01441	0	80	106										G	100685857	C	G	100685857	2	3	69	1	0	0	0	0	0	0	0	1	9974	813	29	1		1	MUC17	7	100685857	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	20839170	100685857	58452806	114	21673										
PARP12	64761	broad.mit.edu	37	chr7	139724424	139724424	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agggtgtgaccgagggcttgGaggaggtggtgtactggatg	21	4	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:139724424G>T	uc003vvl.1	-	12	2916	c.2042C>A	c.(2041-2043)TCC>TAC	p.S681Y	PARP12_uc003vvk.1_Missense_Mutation_p.S467Y|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	681	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					CGAGGGCTTGGAGGAGGTGGT	0.562													1	0	7.93312e-07	0.00245	8.34304e-07	14	50										T	139724424	G	T	139724424	3	4	69	1	0	0	0	0	1	0	0	0	11457	1174	41	3	67	3	PARP12	7	139724424	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	39038567	139724424	19414239	115	21674										
TRPV6	55503	broad.mit.edu	37	chr7	142575431	142575431	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gagctcagatgtcatgggctCaaagaccagctccggggcag	14	11	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:142575431C>T	uc003wbx.1	-	3	538	c.322G>A	c.(322-324)GAG>AAG	p.E108K	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	108	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GTCATGGGCTCAAAGACCAGC	0.587													0	0	0	0.01441	0	58	76										T	142575431	C	T	142575431	3	4	69	1	0	0	0	0	1	0	0	0	16597	835	29	1	1907	1	TRPV6	7	142575431	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2851007	142575431	16563232	116	21675										
OR6B1	135946	broad.mit.edu	37	chr7	143701527	143701527	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctctgcttccgcctcgctctTggttcctgggccattggctt	10	15	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr7:143701527T>A	uc003wdt.1	+	1	438	c.438T>A	c.(436-438)CTT>CTA	p.L146L		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					GCCTCGCTCTTGGTTCCTGGG	0.562													0	0	0	0.013537	0	12	29										A	143701527	T	A	143701527	2	1	69	1	0	0	0	0	0	0	0	1	11187	1799	63	5		5	OR6B1	7	143701527	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	1126096	143701527	15437136	117	21676										
MTUS1	57509	broad.mit.edu	37	chr8	17573306	17573306	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agttttcatcaagtgaacatGagccctggataccaaaggct	9	9	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:17573306G>C	uc003wxv.2	-	5	3028	c.2554C>G	c.(2554-2556)CAT>GAT	p.H852D	MTUS1_uc003wxt.2_Missense_Mutation_p.H99D|MTUS1_uc011kyg.1_5'UTR|MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.H798D	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	852						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		AAGTGAACATGAGCCCTGGAT	0.428													0	0	0	0.004289	0	35	142										C	17573306	G	C	17573306	3	2	69	1	0	0	0	0	1	0	0	0	9965	1290	45	1	1427	1	MTUS1	8	17573306	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		17573306	128790716	118	21677										
FGL1	2267	broad.mit.edu	37	chr8	17739539	17739539	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctcttgcttccaagatcaatGacagtattctcatctccttt	4	12	4	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:17739539G>A	uc003wxx.2	-	4	537	c.213C>T	c.(211-213)GTC>GTT	p.V71V	FGL1_uc003wxy.2_Silent_p.V71V|FGL1_uc003wxz.2_Silent_p.V71V|FGL1_uc003wya.2_Silent_p.V71V|FGL1_uc003wyb.2_Silent_p.V71V|FGL1_uc003wyc.2_Silent_p.V71V|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.V121V|FGL1_uc003wyf.2_Silent_p.V41V	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	71					signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAAGATCAATGACAGTATTCT	0.438													0	0	0	0.013114	0	45	52										A	17739539	G	A	17739539	2	1	69	1	0	0	0	0	0	0	0	1	5872	1277	45	1		1	FGL1	8	17739539	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	166233	17739539	128624483	119	21678										
FZD3	7976	broad.mit.edu	37	chr8	28378298	28378298	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cgggcttacagtgagtgttcGaagctcatggagatgtttgg	15	6	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:28378298G>A	uc003xgx.2	+	4	811	c.333G>A	c.(331-333)TCG>TCA	p.S111S	FZD3_uc010lvb.2_Silent_p.S111S	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	111	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		GTGAGTGTTCGAAGCTCATGG	0.443													0	0	0	0.003755	0	36	102										A	28378298	G	A	28378298	2	1	69	1	0	0	0	0	0	0	0	1	6131	1045	37	1		1	FZD3	8	28378298	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	10638759	28378298	117985724	120	21679										
MYST3	7994	broad.mit.edu	37	chr8	41792359	41792359	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacatcacgttttcgcaaaaGagatactggctttaagatag	8	8	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:41792359G>C	uc010lxb.2	-	18	3923	c.3379C>G	c.(3379-3381)CTT>GTT	p.L1127V	MYST3_uc010lxc.2_Missense_Mutation_p.L1127V|MYST3_uc003xon.3_Missense_Mutation_p.L1127V	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1127					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TTTCGCAAAAGAGATACTGGC	0.413													0	0	0	0.01441	0	51	245										C	41792359	G	C	41792359	3	2	69	1	0	0	0	0	1	0	0	0	10104	942	33	1	2639	1	MYST3	8	41792359	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	13414061	41792359	104571663	121	21680										
IKBKB	3551	broad.mit.edu	37	chr8	42174385	42174385	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agcgggcctggcgttgatccCcgataagcctgccactcagt	12	14	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:42174385C>G	uc003xow.1	+	11	1265	c.1088C>G	c.(1087-1089)CCC>CGC	p.P363R	IKBKB_uc003xov.2_Missense_Mutation_p.P363R|IKBKB_uc010lxh.1_Missense_Mutation_p.P258R|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.P140R|IKBKB_uc003xox.1_Missense_Mutation_p.P84R|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.P361R|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.P304R	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	363					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GCGTTGATCCCCGATAAGCCT	0.577													0	0	0	0.004482	0	8	38										G	42174385	C	G	42174385	3	3	69	1	0	0	0	0	1	0	0	0	7611	623	22	4	1126	4	IKBKB	8	42174385	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	382026	42174385	104189637	122	21681										
KIAA0146	23514	broad.mit.edu	37	chr8	48614292	48614292	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	catttaaacagataaaaactCatctgcctcctccagccttg	4	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:48614292C>T	uc003xqd.2	+	13	1792	c.1783C>T	c.(1783-1785)CAT>TAT	p.H595Y	KIAA0146_uc011ldb.1_Missense_Mutation_p.H595Y|KIAA0146_uc010lxs.2_Missense_Mutation_p.H70Y|KIAA0146_uc011ldc.1_Missense_Mutation_p.H525Y|KIAA0146_uc011ldd.1_Missense_Mutation_p.H535Y|KIAA0146_uc003xqe.2_Missense_Mutation_p.H70Y|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.H284Y|KIAA0146_uc010lxt.2_Missense_Mutation_p.H284Y|KIAA0146_uc011ldf.1_Missense_Mutation_p.H100Y|KIAA0146_uc011ldg.1_Missense_Mutation_p.H85Y|KIAA0146_uc010lxv.1_Missense_Mutation_p.H89Y	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	595											0		Lung NSC(58;0.175)				GATAAAAACTCATCTGCCTCC	0.353													0	0	0	0.01441	0	74	108										T	48614292	C	T	48614292	3	4	69	1	0	0	0	0	1	0	0	0	8157	826	29	1	1833	1	KIAA0146	8	48614292	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	6439907	48614292	97749730	123	21682										
MCM4	4173	broad.mit.edu	37	chr8	48875509	48875509	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	catttttattttctagattaAtgttattggtgagccatttt	6	4	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:48875509A>G	uc003xqk.1	+	7	697	c.602A>G	c.(601-603)AAT>AGT	p.N201S	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.N201S|MCM4_uc011ldi.1_Missense_Mutation_p.N188S|MCM4_uc010lxw.1_RNA	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	201					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TTCTAGATTAATGTTATTGGT	0.284													0	0	0	0.010818	0	34	33										G	48875509	A	G	48875509	3	3	69	1	0	0	0	0	1	0	0	0	9389	101	4	5	624	5	MCM4	8	48875509	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	261217	48875509	97488513	124	21683										
FER1L6	654463	broad.mit.edu	37	chr8	125015463	125015463	+	Missense_Mutation	SNP	G	G	A													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atgggagtaagaagtcagctGaatcagctgaagaagacctc							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:125015463G>A	uc003yqw.2	+	13	1782	c.1576G>A	c.(1576-1578)GAA>AAA	p.E526K	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	526	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAAGTCAGCTGAATCAGCTGA	0.522													0	0	0	0.00333	0	22	41										A	125015463	G	A	125015463	3	1	69	1	0	0	0	0	1	0	0	0	5815	1291	45	1	1622	1	FER1L6	8	125015463	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	76139954	125015463	21348559	125	21684	109	2								
FER1L6	654463	broad.mit.edu	37	chr8	125015471	125015472	+	Frame_Shift_Ins	INS	-	-	A													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agaagtcagctgaatcagctINSgaagaagacctccttccact							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:125015471_125015472insA	uc003yqw.2	+	13	1790_1791	c.1584_1585insA	c.(1582-1587)GCTGAAfs	p.A528fs	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	528_529	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTGAATCAGCTGAAGAAGACCT	0.535																		20	46	---	---								A	125015472	-	A	125015471	7	5	69	1	0	1	1	0	0	0	0	0	5815	1567	55	0	1630	0	FER1L6	8	125015471	Frame_Shift_Ins	INS	-	TCGA-E5-A2PC-01A-11D-A202-08	8	125015471	21348551	126	21685	109	2								
FER1L6	654463	broad.mit.edu	37	chr8	125015577	125015577	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cggagaagccactggtgacaGaagggaacaggtaggagaca	16	7	0	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:125015577G>C	uc003yqw.2	+	13	1896	c.1690G>C	c.(1690-1692)GAA>CAA	p.E564Q	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	564	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACTGGTGACAGAAGGGAACAG	0.507													0	0	0	0.009096	0	2	16										C	125015577	G	C	125015577	3	2	69	1	0	0	0	0	1	0	0	0	5815	943	33	1	1736	1	FER1L6	8	125015577	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	106	125015577	21348445	127	21686										
TSTA3	7264	broad.mit.edu	37	chr8	144696593	144696593	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttggtggggatgacagcggtGaaggtgcagccgtactgctg	18	7	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr8:144696593G>T	uc003yza.2	-	6	531	c.495C>A	c.(493-495)TTC>TTA	p.F165L	TSTA3_uc003yzb.2_Missense_Mutation_p.F165L	NM_003313	NP_003304	Q13630	FCL_HUMAN	tissue specific transplantation antigen P35B	165					'de novo' GDP-L-fucose biosynthetic process|leukocyte cell-cell adhesion		coenzyme binding|electron carrier activity|GDP-4-dehydro-D-rhamnose reductase activity|GDP-L-fucose synthase activity|isomerase activity			pancreas(1)	1	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)		NADH(DB00157)	TGACAGCGGTGAAGGTGCAGC	0.662													1	0	0.00116845	0.001168	0.00119965	5	53										T	144696593	G	T	144696593	3	4	69	1	0	0	0	0	1	0	0	0	16671	1281	45	3	494	3	TSTA3	8	144696593	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	19681016	144696593	1667429	128	21687										
MUSK	4593	broad.mit.edu	37	chr9	113496648	113496648	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	catcacctggattgaaaacgGaaatgctgtgagtgtcatgt	11	7	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr9:113496648G>A	uc004bey.2	+	6	844	c.746G>A	c.(745-747)GGA>GAA	p.G249E	MUSK_uc004bex.2_Missense_Mutation_p.G259E	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	249	Ig-like 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						ATTGAAAACGGAAATGCTGTG	0.507													0	0	0	0.010504	0	20	4										A	113496648	G	A	113496648	3	1	69	1	0	0	0	0	1	0	0	0	9989	1174	41	1	802	1	MUSK	9	113496648	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		113496648	27716783	129	21688										
PRPF4	9128	broad.mit.edu	37	chr9	116053237	116053237	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agtgtgggacctccgacagcGgcgttgcgtctacaccatcc	12	14	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr9:116053237G>T	uc004bgx.2	+	13	1366	c.1316G>T	c.(1315-1317)CGG>CTG	p.R439L	PRPF4_uc004bgy.2_Missense_Mutation_p.R438L	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	439	WD 5.					Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						CTCCGACAGCGGCGTTGCGTC	0.468													1	0	1.49673e-21	0.00623	1.68139e-21	40	15										T	116053237	G	T	116053237	3	4	69	1	0	0	0	0	1	0	0	0	12570	1116	39	4	1366	4	PRPF4	9	116053237	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	2556589	116053237	25160194	130	21689										
RSU1	6251	broad.mit.edu	37	chr10	16824066	16824066	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atggctgaggaccagttgtgTgatatgggataaggtaacta	14	4	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:16824066T>C	uc001iok.2	-	2	429	c.127A>G	c.(127-129)ACA>GCA	p.T43A	RSU1_uc001iol.2_Missense_Mutation_p.T43A|RSU1_uc001iom.2_5'UTR|RSU1_uc001ion.2_Missense_Mutation_p.T43A	NM_152724	NP_689937	Q15404	RSU1_HUMAN	ras suppressor protein 1 isoform 2	43	LRR 1.				cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(1;7.54e-08)		ACCAGTTGTGTGATATGGGAT	0.373													0	0	0	0.004482	0	8	35										C	16824066	T	C	16824066	3	2	69	1	0	0	0	0	1	0	0	0	13716	1696	59	5	734	5	RSU1	10	16824066	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08		16824066	118710681	131	21690										
ANKRD30A	91074	broad.mit.edu	37	chr10	37486374	37486374	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aagtctgttccaaataaagcCttggaattgaagaatgaaca	8	6	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:37486374C>A	uc001iza.1	+	29	2613	c.2514C>A	c.(2512-2514)GCC>GCA	p.A838A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	894						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAAATAAAGCCTTGGAATTGA	0.318													1	0	6.97489e-18	0.004878	7.75984e-18	28	34										A	37486374	C	A	37486374	2	1	69	1	0	0	0	0	0	0	0	1	658	668	24	4		4	ANKRD30A	10	37486374	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	20662308	37486374	98048373	132	21691										
CHAT	1103	broad.mit.edu	37	chr10	50872873	50872873	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tatggtcctgtggtcccaaaTgggtatggtgcctgctacaa	12	9	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:50872873T>C	uc001jhz.2	+	15	2181	c.2028T>C	c.(2026-2028)AAT>AAC	p.N676N	CHAT_uc001jhv.1_Silent_p.N558N|CHAT_uc001jhx.1_Silent_p.N558N|CHAT_uc001jhy.1_Silent_p.N558N|CHAT_uc001jia.2_Silent_p.N558N|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	676					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TGGTCCCAAATGGGTATGGTG	0.537													0	0	0	0.01441	0	48	137										C	50872873	T	C	50872873	2	2	69	1	0	0	0	0	0	0	0	1	3313	1461	51	5		5	CHAT	10	50872873	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	13386499	50872873	84661874	133	21692										
KIAA0913	23053	broad.mit.edu	37	chr10	75545836	75545836	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aggtggcagtggcggtaccaGaatgcgaggtgagagtgagc	19	6	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:75545836G>A	uc009xrl.2	+	1	232	c.200G>A	c.(199-201)AGA>AAA	p.R67K	KIAA0913_uc009xrk.1_3'UTR|KIAA0913_uc001jve.2_Missense_Mutation_p.R67K|KIAA0913_uc001jvf.2_Missense_Mutation_p.R67K|uc009xrm.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	67							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					GGCGGTACCAGAATGCGAGGT	0.692													0	0	0	0.004672	0	3	10										A	75545836	G	A	75545836	3	1	69	1	0	0	0	0	1	0	0	0	8200	942	33	1	202	1	KIAA0913	10	75545836	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	24672963	75545836	59988911	134	21693										
CEP55	55165	broad.mit.edu	37	chr10	95287764	95287764	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcactttccaaggagagactGaaaacagagaaaaagttgcc	9	8	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:95287764G>A	uc009xug.2	+	9	1431	c.1249G>A	c.(1249-1251)GAA>AAA	p.E417K	CEP55_uc001kiq.3_Missense_Mutation_p.E417K	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	417	Required for localization to the interphase centrosome and to the midbody during cytokinesis.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				AGGAGAGACTGAAAACAGAGA	0.418													0	0	0	0.001855	0	12	26										A	95287764	G	A	95287764	3	1	69	1	0	0	0	0	1	0	0	0	3255	1291	45	1	1279	1	CEP55	10	95287764	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	19741928	95287764	40246983	135	21694										
ZNF518A	9849	broad.mit.edu	37	chr10	97920088	97920088	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcccttttagttctaaacagCttgtgaaatgtctaggagaa	8	7	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:97920088C>T	uc001klp.2	+	6	4866	c.4009C>T	c.(4009-4011)CTT>TTT	p.L1337F	ZNF518A_uc001klo.1_Missense_Mutation_p.L807F|ZNF518A_uc001klq.2_Missense_Mutation_p.L1337F|ZNF518A_uc001klr.2_Missense_Mutation_p.L1337F	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TTCTAAACAGCTTGTGAAATG	0.378													0	0	0	0.000602	0	5	15										T	97920088	C	T	97920088	3	4	69	1	0	0	0	0	1	0	0	0	17959	797	28	2	4011	2	ZNF518A	10	97920088	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2632324	97920088	37614659	136	21695										
SLIT1	6585	broad.mit.edu	37	chr10	98794286	98794286	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcttaaggaactgatcttgtTgttgctcaggtccctggaaa	11	8	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:98794286T>G	uc001kmw.2	-	23	2632	c.2380A>C	c.(2380-2382)AAC>CAC	p.N794H	SLIT1_uc009xvh.1_Intron	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	794	LRR 18.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CTGATCTTGTTGTTGCTCAGG	0.562													0	0	0	0.008361	0	29	37										G	98794286	T	G	98794286	3	3	69	1	0	0	0	0	1	0	0	0	14739	1812	63	5	2284	5	SLIT1	10	98794286	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	874198	98794286	36740461	137	21696										
CHUK	1147	broad.mit.edu	37	chr10	101977825	101977825	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	taaggtcaacaggtcctcctCtctgctgagggtcccaattc	9	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:101977825C>G	uc001kqp.2	-	9	915	c.860G>C	c.(859-861)AGA>ACA	p.R287T		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	287	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AGGTCCTCCTCTCTGCTGAGG	0.373													0	0	0	0.010729	0	12	7										G	101977825	C	G	101977825	3	3	69	1	0	0	0	0	1	0	0	0	3416	913	32	1	1429	1	CHUK	10	101977825	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	3183539	101977825	33556922	138	21697										
NFKB2	4791	broad.mit.edu	37	chr10	104157318	104157318	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gagctggagcaagaggccaaAgaactgaagaaggtgatgga	16	5	0	5			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:104157318A>G	uc001kvb.2	+	8	802	c.537A>G	c.(535-537)AAA>AAG	p.K179K	NFKB2_uc001kva.2_Silent_p.K179K|NFKB2_uc010qqk.1_Silent_p.K179K|NFKB2_uc001kvd.2_Silent_p.K179K|NFKB2_uc009xxc.2_Silent_p.K179K	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	179	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		AAGAGGCCAAAGAACTGAAGA	0.592			T	IGH@	B-NHL								0	0	0	0.004878	0	38	65										G	104157318	A	G	104157318	2	3	69	1	0	0	0	0	0	0	0	1	10376	69	3	5		5	NFKB2	10	104157318	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	2179493	104157318	31377429	139	21698										
ABLIM1	3983	broad.mit.edu	37	chr10	116247730	116247730	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tccttacccgcagcttttccTcggtcttcgtagattgctta	7	13	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:116247730T>A	uc010qsg.1	-	8	1127	c.1028A>T	c.(1027-1029)GAG>GTG	p.E343V	ABLIM1_uc010qsh.1_Missense_Mutation_p.E283V|ABLIM1_uc010qsi.1_Missense_Mutation_p.E283V|ABLIM1_uc010qsk.1_Missense_Mutation_p.E267V|ABLIM1_uc009xyp.2_Missense_Mutation_p.E277V|ABLIM1_uc010qsf.1_Missense_Mutation_p.E27V|ABLIM1_uc009xyn.2_Missense_Mutation_p.E20V|ABLIM1_uc010qsj.1_Missense_Mutation_p.E20V|ABLIM1_uc009xyo.2_Missense_Mutation_p.E191V	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	343	LIM zinc-binding 4.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CAGCTTTTCCTCGGTCTTCGT	0.478													0	0	0	0.00333	0	23	60										A	116247730	T	A	116247730	3	1	69	1	0	0	0	0	1	0	0	0	94	1551	54	5	1456	5	ABLIM1	10	116247730	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	12090412	116247730	19287017	140	21699										
PNLIP	5406	broad.mit.edu	37	chr10	118305637	118305637	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tggactctttcactgctgctGggagcagtagcaggtaagaa	13	8	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:118305637G>A	uc001lcm.2	+	2	76	c.33G>A	c.(31-33)CTG>CTA	p.L11L		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	11					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CACTGCTGCTGGGAGCAGTAG	0.433													0	0	0	0.001855	0	13	25										A	118305637	G	A	118305637	2	1	69	1	0	0	0	0	0	0	0	1	12149	1335	47	2		2	PNLIP	10	118305637	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	2057907	118305637	17229110	141	21700										
WDR11	55717	broad.mit.edu	37	chr10	122624668	122624668	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttttaatccttgaccttgagGtgaatcagacggtgggtgtg	13	6	1	4	rs145467317		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:122624668G>C	uc010qtf.1	+	6	1061	c.823G>C	c.(823-825)GTG>CTG	p.V275L	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	275						integral to membrane					0						TGACCTTGAGGTGAATCAGAC	0.378													0	0	0	0.006122	0	19	28										C	122624668	G	C	122624668	3	2	69	1	0	0	0	0	1	0	0	0	17270	1261	44	4	845	4	WDR11	10	122624668	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	4319031	122624668	12910079	142	21701										
DMBT1	1755	broad.mit.edu	37	chr10	124399605	124399605	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cttcctcacagcagctgtctCaggtggcatcatcaagagga	10	12	4	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr10:124399605C>T	uc001lgk.1	+	52	6711	c.6605C>T	c.(6604-6606)TCA>TTA	p.S2202L	DMBT1_uc001lgl.1_Missense_Mutation_p.S2192L|DMBT1_uc001lgm.1_Missense_Mutation_p.S1574L|DMBT1_uc009xzz.1_Missense_Mutation_p.S2201L|DMBT1_uc010qtx.1_Missense_Mutation_p.S922L|DMBT1_uc009yab.1_Missense_Mutation_p.S905L|DMBT1_uc009yac.1_Missense_Mutation_p.S496L	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2202	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCAGCTGTCTCAGGTGGCATC	0.522													0	0	0	0.008361	0	31	30										T	124399605	C	T	124399605	3	4	69	1	0	0	0	0	1	0	0	0	4577	838	29	1	6811	1	DMBT1	10	124399605	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1774937	124399605	11135142	143	21702										
PKP3	11187	broad.mit.edu	37	chr11	404268	404268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gaagtcctcccgggcagcatCcagcctcctggccaacctgt	10	17	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:404268C>T	uc001lpc.2	+	12	2379	c.2303C>T	c.(2302-2304)TCC>TTC	p.S768F		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	768					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGGGCAGCATCCAGCCTCCTG	0.662													0	0	0	0.008361	0	27	55										T	404268	C	T	404268	3	4	69	1	0	0	0	0	1	0	0	0	11986	855	30	1	2349	1	PKP3	11	404268	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08		404268	134602248	144	21703										
ABCC8	6833	broad.mit.edu	37	chr11	17428979	17428979	+	Frame_Shift_Del	DEL	C	C	-													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccctggggtggctctgtggCttttctctctgtgacagtct							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:17428979delC	uc001mnc.2	-	24	2968	c.2842delG	c.(2842-2844)GCCfs	p.A948fs		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	948	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGCTCTGTGGCTTTTCTCTCT	0.542																		20	78	---	---								-	17428979	C	-	17428979	7	5	69	1	0	1	0	1	0	0	0	0	58	797	28	0	1967	0	ABCC8	11	17428979	Frame_Shift_Del	DEL	C	TCGA-E5-A2PC-01A-11D-A202-08	17024711	17428979	117577537	145	21704										
TRAF6	7189	broad.mit.edu	37	chr11	36523047	36523047	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gctggatccacagctgttttCacagtttagcagactcatag	9	10	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:36523047C>T	uc001mwr.1	-	3	359	c.19G>A	c.(19-21)GAA>AAA	p.E7K	TRAF6_uc001mws.1_Missense_Mutation_p.E7K	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	7	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				CAGCTGTTTTCACAGTTTAGC	0.448													0	0	0	0.010729	0	11	17										T	36523047	C	T	36523047	3	4	69	1	0	0	0	0	1	0	0	0	16442	835	29	1	1573	1	TRAF6	11	36523047	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	19094068	36523047	98483469	146	21705										
OR4A16	81327	broad.mit.edu	37	chr11	55110736	55110736	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggcctcactcaagatcctgaTgtgaaaaaaacattatttgt	7	8	2	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:55110736T>A	uc010rie.1	+	1	60	c.60T>A	c.(58-60)GAT>GAA	p.D20E		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						AAGATCCTGATGTGAAAAAAA	0.413													0	0	0	0.001168	0	6	9										A	55110736	T	A	55110736	3	1	69	1	0	0	0	0	1	0	0	0	11041	1461	51	5	62	5	OR4A16	11	55110736	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	18587689	55110736	79895780	147	21706										
OR5L2	26338	broad.mit.edu	37	chr11	55595538	55595538	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccgtgttctacacagttgtgAttcccatgctgaaccccctg	8	14	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:55595538A>T	uc001nhy.1	+	1	844	c.844A>T	c.(844-846)ATT>TTT	p.I282F		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CACAGTTGTGATTCCCATGCT	0.463										HNSCC(27;0.073)			0	0	0	0.006214	0	8	9										T	55595538	A	T	55595538	3	4	69	1	0	0	0	0	1	0	0	0	11171	333	12	5	846	5	OR5L2	11	55595538	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	484802	55595538	79410978	148	21707										
OR8H1	219469	broad.mit.edu	37	chr11	56058390	56058390	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgtgaagctggaggtccaggCggattatcaatatcatcccc	11	10	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:56058390C>T	uc010rje.1	-	1	149	c.149G>A	c.(148-150)CGC>CAC	p.R50H		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GAGGTCCAGGCGGATTATCAA	0.423													0	0	0	0.01441	0	80	115										T	56058390	C	T	56058390	3	4	69	1	0	0	0	0	1	0	0	0	11237	768	27	2	788	2	OR8H1	11	56058390	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	462852	56058390	78948126	149	21708										
UBE2L6	9246	broad.mit.edu	37	chr11	57319864	57319864	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tccactccgaatcggagggtGaactcttcggcattctttct	9	12	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:57319864G>A	uc001nkn.1	-	4	525	c.429C>T	c.(427-429)TTC>TTT	p.F143F	UBE2L6_uc001nko.1_Silent_p.F77F	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	143					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						ATCGGAGGGTGAACTCTTCGG	0.572													0	0	0	0.01441	0	71	99										A	57319864	G	A	57319864	2	1	69	1	0	0	0	0	0	0	0	1	16861	1281	45	1		1	UBE2L6	11	57319864	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	1261474	57319864	77686652	150	21709										
SIPA1	6494	broad.mit.edu	37	chr11	65417623	65417623	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccacaggacagcccatcccaGagagtggagaccctaaggga	12	13	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:65417623G>C	uc001ofb.2	+	14	3030	c.2863G>C	c.(2863-2865)GAG>CAG	p.E955Q	SIPA1_uc010rom.1_Missense_Mutation_p.E853Q|SIPA1_uc001ofd.2_Missense_Mutation_p.E955Q	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	955					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GCCCATCCCAGAGAGTGGAGA	0.607													0	0	0	0.01441	0	43	76										C	65417623	G	C	65417623	3	2	69	1	0	0	0	0	1	0	0	0	14328	943	33	1	2913	1	SIPA1	11	65417623	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	8097759	65417623	69588893	151	21710										
MTL5	9633	broad.mit.edu	37	chr11	68517984	68517984	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcccaggtacgcttctttgaAgacgtggaactcgtcctcct	10	13	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:68517984A>T	uc001ooc.2	-	2	285	c.145T>A	c.(145-147)TTC>ATC	p.F49I	MTL5_uc001ood.1_Missense_Mutation_p.F49I|MTL5_uc009ysi.1_Missense_Mutation_p.F49I|MTL5_uc001ooe.2_Missense_Mutation_p.F49I	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	49					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GCTTCTTTGAAGACGTGGAAC	0.647													0	0	0	0.000602	0	5	15										T	68517984	A	T	68517984	3	4	69	1	0	0	0	0	1	0	0	0	9936	72	3	5	1421	5	MTL5	11	68517984	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	3100361	68517984	66488532	152	21711										
CHORDC1	26973	broad.mit.edu	37	chr11	89956187	89956187	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcaagaggatgcgtttgccaCtcccgtgtcgctagcaccgg	13	13	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:89956187C>T	uc001pdg.2	-	1	346	c.-64G>A	c.(-66--62)GAGTG>GAATG		CHORDC1_uc009yvz.2_Translation_Start_Site	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing						chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				GCGTTTGCCACTCCCGTGTCG	0.602													0	0	0	0.00308	0	7	12										T	89956187	C	T	89956187	1	4	69	1	0	0	0	0	0	0	0	0	3365	580	20	2		2	CHORDC1	11	89956187	Translation_Start_Site	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	21438203	89956187	45050329	153	21712										
ADAMTS8	11095	broad.mit.edu	37	chr11	130275730	130275730	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgtatttgacttttggggggAagacctcgccagggactgtc	14	8	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr11:130275730A>T	uc001qgg.3	-	9	2751	c.2393T>A	c.(2392-2394)TTC>TAC	p.F798Y	ADAMTS8_uc001qgf.2_Missense_Mutation_p.F279Y	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	798	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TTTTGGGGGGAAGACCTCGCC	0.567													0	0	0	0.01441	0	110	34										T	130275730	A	T	130275730	3	4	69	1	0	0	0	0	1	0	0	0	272	246	9	5	280	5	ADAMTS8	11	130275730	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	40319543	130275730	4730786	154	21713										
CACNA1C	775	broad.mit.edu	37	chr12	2786965	2786965	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccatctctggagatctcaccGctgaggaggagctggacaag	13	11	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:2786965G>A	uc009zdu.1	+	43	5480	c.5167G>A	c.(5167-5169)GCT>ACT	p.A1723T	CACNA1C_uc009zdv.1_Missense_Mutation_p.A1672T|CACNA1C_uc001qkb.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkc.2_Missense_Mutation_p.A1694T|CACNA1C_uc001qke.2_Missense_Mutation_p.A1664T|CACNA1C_uc001qkf.2_Missense_Mutation_p.A1683T|CACNA1C_uc001qjz.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkd.2_Missense_Mutation_p.A1694T|CACNA1C_uc001qkg.2_Missense_Mutation_p.A1681T|CACNA1C_uc009zdw.1_Missense_Mutation_p.A1716T|CACNA1C_uc001qkh.2_Missense_Mutation_p.A1683T|CACNA1C_uc001qkl.2_Missense_Mutation_p.A1723T|CACNA1C_uc001qkn.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qko.2_Missense_Mutation_p.A1695T|CACNA1C_uc001qkp.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkr.2_Missense_Mutation_p.A1692T|CACNA1C_uc001qku.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkq.2_Missense_Mutation_p.A1703T|CACNA1C_uc001qks.2_Missense_Mutation_p.A1675T|CACNA1C_uc001qkt.2_Missense_Mutation_p.A1694T|CACNA1C_uc001qki.1_Missense_Mutation_p.A1411T|CACNA1C_uc001qkj.1_Missense_Mutation_p.A1411T|CACNA1C_uc001qkk.1_Missense_Mutation_p.A1411T|CACNA1C_uc001qkm.1_Missense_Mutation_p.A1400T|CACNA1C_uc010sea.1_Missense_Mutation_p.A366T|uc001qkx.1_RNA|CACNA1C_uc001qky.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1723	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGATCTCACCGCTGAGGAGGA	0.612													0	0	0	0.008361	0	30	18										A	2786965	G	A	2786965	3	1	69	1	0	0	0	0	1	0	0	0	2540	1087	38	2	5568	2	CACNA1C	12	2786965	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		2786965	131064930	155	21714										
ATN1	1822	broad.mit.edu	37	chr12	7043167	7043167	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtctccacagcctgaagaatGaagacacgacagaataaaga	9	9	1	6			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:7043167G>A	uc001qrw.1	+	2	240	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ATN1_uc001qrx.1_Missense_Mutation_p.M1I|ATN1_uc001qry.1_Missense_Mutation_p.M1I	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	1					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCTGAAGAATGAAGACACGAC	0.517													0	0	0	0.001168	0	6	12										A	7043167	G	A	7043167	3	1	69	1	0	0	0	0	1	0	0	0	1111	1290	45	1	5	1	ATN1	12	7043167	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	4256202	7043167	126808728	156	21715										
CD163	9332	broad.mit.edu	37	chr12	7655119	7655119	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	actgagaagtaagaccacagTaatggtgaagggactcaagt	12	6	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:7655119T>G	uc001qsz.3	-	2	216	c.88A>C	c.(88-90)ACT>CCT	p.T30P	CD163_uc001qta.3_Missense_Mutation_p.T30P|CD163_uc009zfw.2_Missense_Mutation_p.T30P	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	30					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						aagaccacagtaatggtgaag	0.234													0	0	0	0.004672	0	2	5										G	7655119	T	G	7655119	3	3	69	1	0	0	0	0	1	0	0	0	2967	1638	57	5	3442	5	CD163	12	7655119	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	611952	7655119	126196776	157	21716										
A2ML1	144568	broad.mit.edu	37	chr12	8988145	8988145	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacagtggctggaagtggtaCctgagcaaggcattgtagac	14	8	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:8988145C>T	uc001quz.3	+	6	624	c.526C>T	c.(526-528)CCT>TCT	p.P176S		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	20						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGAAGTGGTACCTGAGCAAGG	0.527													0	0	0	0.006122	0	17	53										T	8988145	C	T	8988145	3	4	69	1	0	0	0	0	1	0	0	0	5	507	18	2	548	2	A2ML1	12	8988145	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1333026	8988145	124863750	158	21717										
A2M	2	broad.mit.edu	37	chr12	9232332	9232332	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tagatgttaggagcaaagagGaccatattctgctctccaca	9	9	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:9232332G>C	uc001qvk.1	-	24	3047	c.2934C>G	c.(2932-2934)GTC>GTG	p.V978V	A2M_uc001qvj.1_Silent_p.V20V|A2M_uc009zgk.1_Silent_p.V828V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	978					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GAGCAAAGAGGACCATATTCT	0.453													0	0	0	0.001984	0	5	7										C	9232332	G	C	9232332	2	2	69	1	0	0	0	0	0	0	0	1	4	1161	41	1		1	A2M	12	9232332	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	244187	9232332	124619563	159	21718										
GPR19	2842	broad.mit.edu	37	chr12	12814505	12814505	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggtgccatagctgagctacaTgaaaaggcagccaggagagc	14	9	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:12814505T>C	uc001rar.3	-	2	1071	c.878A>G	c.(877-879)CAT>CGT	p.H293R	GPR19_uc001raq.2_Missense_Mutation_p.H293R	NM_006143	NP_006134	Q15760	GPR19_HUMAN	G protein-coupled receptor 19	293	Helical; Name=6; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		CTGAGCTACATGAAAAGGCAG	0.408													0	0	0	0.004482	0	9	23										C	12814505	T	C	12814505	3	2	69	1	0	0	0	0	1	0	0	0	6679	1464	51	5	373	5	GPR19	12	12814505	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	3582173	12814505	121037390	160	21719										
PLEKHA9	51054	broad.mit.edu	37	chr12	45567437	45567437	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atccatcttaacaggagcaaAcactgtagggccaagtttgt	9	9	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:45567437A>G	uc001rom.1	-	3	1249	c.712T>C	c.(712-714)TTT>CTT	p.F238L	PLEKHA9_uc009zke.2_Missense_Mutation_p.F238L	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		ACAGGAGCAAACACTGTAGGG	0.393													0	0	0	0.01441	0	70	70										G	45567437	A	G	45567437	3	3	69	1	0	0	0	0	1	0	0	0	12063	43	2	5	467	5	PLEKHA9	12	45567437	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	32752932	45567437	88284458	161	21720										
ESPL1	9700	broad.mit.edu	37	chr12	53670542	53670542	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atctgtgacctcctggagctGagccccgaggagacaccagc	12	14	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:53670542G>A	uc001sck.2	+	8	1930	c.1839G>A	c.(1837-1839)CTG>CTA	p.L613L	ESPL1_uc001scj.2_Silent_p.L288L|ESPL1_uc010soe.1_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	613					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TCCTGGAGCTGAGCCCCGAGG	0.642													0	0	0	0.003163	0	15	52										A	53670542	G	A	53670542	2	1	69	1	0	0	0	0	0	0	0	1	5253	1277	45	1		1	ESPL1	12	53670542	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	8103105	53670542	80181353	162	21721										
MMP19	4327	broad.mit.edu	37	chr12	56236139	56236139	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacctcatagcttctcacctCagagcctcggtgatatcttc	6	15	4	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:56236139C>A	uc001sib.2	-	2	292	c.171G>T	c.(169-171)CTG>CTT	p.L57L	MMP19_uc001sia.2_5'Flank|MMP19_uc001sid.2_RNA|MMP19_uc010spw.1_Silent_p.L57L	NM_002429	NP_002420	Q99542	MMP19_HUMAN	matrix metalloproteinase 19 isoform rasi-1	57					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)	1						CTTCTCACCTCAGAGCCTCGG	0.502													1	0	1.64293e-13	0.00333	1.79891e-13	24	74										A	56236139	C	A	56236139	2	1	69	1	0	0	0	0	0	0	0	1	9657	813	29	3		3	MMP19	12	56236139	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2565597	56236139	77615756	163	21722										
LRP1	4035	broad.mit.edu	37	chr12	57550039	57550039	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acaagggtggtgccctccacAtctaccaccagaggcgtcag	11	14	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:57550039A>G	uc001snd.2	+	9	1856	c.1390A>G	c.(1390-1392)ATC>GTC	p.I464V		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	464	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGCCCTCCACATCTACCACCA	0.607													0	0	0	0.00308	0	8	39										G	57550039	A	G	57550039	3	3	69	1	0	0	0	0	1	0	0	0	8951	217	8	5	1424	5	LRP1	12	57550039	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	1313900	57550039	76301856	164	21723										
GLI1	2735	broad.mit.edu	37	chr12	57865459	57865459	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaattttgtagtgggggcaaAtagggcttcacatagggcag	14	5	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:57865459A>G	uc001snx.2	+	12	3014	c.2936A>G	c.(2935-2937)AAT>AGT	p.N979S	GLI1_uc009zpq.2_Missense_Mutation_p.N851S	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	979					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			GTGGGGGCAAATAGGGCTTCA	0.537													0	0	0	0.004656	0	27	86										G	57865459	A	G	57865459	3	3	69	1	0	0	0	0	1	0	0	0	6437	101	4	5	2978	5	GLI1	12	57865459	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	315420	57865459	75986436	165	21724										
E2F7	144455	broad.mit.edu	37	chr12	77458337	77458337	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcttaccttttgtgcattttCcccatcttcaactgcaaaat	4	12	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:77458337C>G	uc001sym.3	-	2	315	c.79G>C	c.(79-81)GAA>CAA	p.E27Q	E2F7_uc001syn.2_Missense_Mutation_p.E27Q	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	27					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						TGTGCATTTTCCCCATCTTCA	0.373													0	0	0	0.010504	0	19	58										G	77458337	C	G	77458337	3	3	69	1	0	0	0	0	1	0	0	0	4872	864	30	1	2704	1	E2F7	12	77458337	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	19592878	77458337	56393558	166	21725										
KERA	11081	broad.mit.edu	37	chr12	91449916	91449916	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cagtaggaaaactgggtgggCagaaacattccatgggacac	13	8	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:91449916C>G	uc001tbl.2	-	2	762	c.143G>C	c.(142-144)TGC>TCC	p.C48S		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	48	LRRNT.|Cys-rich.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ACTGGGTGGGCAGAAACATTC	0.393													0	0	0	0.000602	0	4	6										G	91449916	C	G	91449916	3	3	69	1	0	0	0	0	1	0	0	0	8143	710	25	4	923	4	KERA	12	91449916	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	13991579	91449916	42401979	167	21726										
IKBIP	121457	broad.mit.edu	37	chr12	99038453	99038453	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggggctcccttgggccccgaCttcttccggctcttcacctc	10	18	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:99038453C>A	uc001tfv.2	-	1	137	c.27G>T	c.(25-27)AAG>AAT	p.K9N	APAF1_uc001tfy.2_5'Flank|APAF1_uc001tfz.2_5'Flank|APAF1_uc001tga.2_5'Flank|APAF1_uc001tgb.2_5'Flank|APAF1_uc001tgc.2_5'Flank|IKBIP_uc001tfw.2_Missense_Mutation_p.K9N|IKBIP_uc001tfx.2_Missense_Mutation_p.K9N	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	9					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TGGGCCCCGACTTCTTCCGGC	0.706													1	0	1.05317e-09	0.00245	1.13167e-09	12	34										A	99038453	C	A	99038453	3	1	69	1	0	0	0	0	1	0	0	0	7609	564	20	4	1878	4	IKBIP	12	99038453	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	7588537	99038453	34813442	168	21727										
UTP20	27340	broad.mit.edu	37	chr12	101745949	101745949	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	catgtcttacaaacgggacaGatcaatcaaaaactgggtgt	9	8	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:101745949G>C	uc001tia.1	+	39	5157	c.5001G>C	c.(4999-5001)CAG>CAC	p.Q1667H		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1667					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AAACGGGACAGATCAATCAAA	0.299													0	0	0	0.001855	0	12	43										C	101745949	G	C	101745949	3	2	69	1	0	0	0	0	1	0	0	0	17096	933	33	1	5155	1	UTP20	12	101745949	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	2707496	101745949	32105946	169	21728										
UTP20	27340	broad.mit.edu	37	chr12	101760349	101760349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ttgacagaaatccagtagccCcagcaccagatccacgtcta	7	14	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:101760349C>T	uc001tia.1	+	47	6295	c.6139C>T	c.(6139-6141)CCA>TCA	p.P2047S		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2047					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TCCAGTAGCCCCAGCACCAGA	0.512													0	0	0	0.01441	0	45	39										T	101760349	C	T	101760349	3	4	69	1	0	0	0	0	1	0	0	0	17096	623	22	2	6325	2	UTP20	12	101760349	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	14400	101760349	32091546	170	21729										
DNAH10	196385	broad.mit.edu	37	chr12	124341734	124341734	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctcgcgtccgctaccctgaCttcaacgatgcggtagagca	10	15	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr12:124341734C>T	uc001uft.3	+	36	6241	c.6216C>T	c.(6214-6216)GAC>GAT	p.D2072D		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2072					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCTACCCTGACTTCAACGATG	0.532													0	0	0	0.00499	0	17	54										T	124341734	C	T	124341734	2	4	69	1	0	0	0	0	0	0	0	1	4598	564	20	2		2	DNAH10	12	124341734	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	22581385	124341734	9510161	171	21730										
FAM124A	220108	broad.mit.edu	37	chr13	51855235	51855235	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cagctcctcagcgacagctcGtgctgctcccccagctccca	8	20	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr13:51855235G>T	uc001vfg.1	+	4	1615	c.1484G>T	c.(1483-1485)CGT>CTT	p.R495L	FAM124A_uc001vff.1_Missense_Mutation_p.R531L	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	495										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		GCGACAGCTCGTGCTGCTCCC	0.612													1	0	1.39806e-14	0.008361	1.54545e-14	28	46										T	51855235	G	T	51855235	3	4	69	1	0	0	0	0	1	0	0	0	5425	1145	40	4	1610	4	FAM124A	13	51855235	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		51855235	63314643	172	21731										
ABCC4	10257	broad.mit.edu	37	chr13	95840790	95840790	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccttgtagagttggggtctCtgatgcctacaaattaaagt	11	7	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr13:95840790C>T	uc001vmd.3	-	10	1389	c.1270G>A	c.(1270-1272)GAG>AAG	p.E424K	ABCC4_uc010afk.2_Missense_Mutation_p.E424K|ABCC4_uc001vme.2_Missense_Mutation_p.E424K|ABCC4_uc010tih.1_Missense_Mutation_p.E349K|ABCC4_uc001vmf.2_Missense_Mutation_p.E381K|ABCC4_uc010afl.1_Missense_Mutation_p.E381K|ABCC4_uc010afm.1_Missense_Mutation_p.E437K	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	424	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GTTGGGGTCTCTGATGCCTAC	0.418													0	0	0	0.00333	0	25	49										T	95840790	C	T	95840790	3	4	69	1	0	0	0	0	1	0	0	0	55	922	32	1	2844	1	ABCC4	13	95840790	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	43985555	95840790	19329088	173	21732										
AP1G2	8906	broad.mit.edu	37	chr14	24029009	24029009	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acctcaaagatctcctgcacCgactggtgaaagtggtcgta	10	11	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:24029009C>T	uc001wkl.2	-	22	2644	c.2307G>A	c.(2305-2307)TCG>TCA	p.S769S	AP1G2_uc001wkj.2_Silent_p.S388S|AP1G2_uc001wkk.3_Silent_p.S697S|AP1G2_uc001wkn.2_Silent_p.S388S|uc001wko.1_5'Flank	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	769	GAE.				interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		TCTCCTGCACCGACTGGTGAA	0.562											OREG0022604	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	9	39										T	24029009	C	T	24029009	2	4	69	1	0	0	0	0	0	0	0	1	733	639	23	2		2	AP1G2	14	24029009	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08		24029009	83320531	174	21733										
NYNRIN	57523	broad.mit.edu	37	chr14	24884981	24884981	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agcccccctgtctccctttcCttctcctgctccccttacac	3	22	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:24884981C>T	uc001wpf.3	+	9	4344	c.4026C>T	c.(4024-4026)TCC>TCT	p.S1342S		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1342					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TCTCCCTTTCCTTCTCCTGCT	0.607													0	0	0	0.01441	0	96	122										T	24884981	C	T	24884981	2	4	69	1	0	0	0	0	0	0	0	1	10796	668	24	2		2	NYNRIN	14	24884981	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	855972	24884981	82464559	175	21734										
FOXA1	3169	broad.mit.edu	37	chr14	38061313	38061313	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgccaccttgacgaagcagtCattgaaggacagcgagtggc	13	10	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:38061313C>T	uc001wuf.2	-	2	988	c.676G>A	c.(676-678)GAC>AAC	p.D226N	FOXA1_uc010tpz.1_Missense_Mutation_p.D193N	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	226	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		ACGAAGCAGTCATTGAAGGAC	0.607													0	0	0	0.00874	0	35	30										T	38061313	C	T	38061313	3	4	69	1	0	0	0	0	1	0	0	0	5989	826	29	1	746	1	FOXA1	14	38061313	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	13176332	38061313	69288227	176	21735										
NIN	51199	broad.mit.edu	37	chr14	51224125	51224125	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacagtccgcacataacatcAttagctgttcctgaagctga	7	12	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:51224125A>T	uc001wym.2	-	18	3814	c.3623T>A	c.(3622-3624)ATG>AAG	p.M1208K	NIN_uc001wyi.2_Missense_Mutation_p.M1208K|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.M1214K|NIN_uc001wyo.2_Missense_Mutation_p.M1208K	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1208	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					ACATAACATCATTAGCTGTTC	0.418			T	PDGFRB	MPD								0	0	0	0.01441	0	51	80										T	51224125	A	T	51224125	3	4	69	1	0	0	0	0	1	0	0	0	10417	217	8	5	2982	5	NIN	14	51224125	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	13162812	51224125	56125415	177	21736										
KTN1	3895	broad.mit.edu	37	chr14	56107858	56107858	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctcatagtgtttatgttaaaGatgataaaataagattgctg	8	3	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:56107858G>C	uc001xcb.2	+	18	2337	c.2035G>C	c.(2035-2037)GAT>CAT	p.D679H	KTN1_uc001xce.2_Missense_Mutation_p.D679H|KTN1_uc001xcc.2_Missense_Mutation_p.D679H|KTN1_uc001xcd.2_Missense_Mutation_p.D679H|KTN1_uc010trb.1_Missense_Mutation_p.D679H|KTN1_uc001xcf.1_Missense_Mutation_p.D679H	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	679	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TTATGTTAAAGATGATAAAAT	0.303			T	RET	papillary thryoid								0	0	0	0.001984	0	7	14										C	56107858	G	C	56107858	3	2	69	1	0	0	0	0	1	0	0	0	8585	942	33	1	2097	1	KTN1	14	56107858	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	4883733	56107858	51241682	178	21737										
C14orf37	145407	broad.mit.edu	37	chr14	58605192	58605192	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtgctgacactcactgtgacTtctggggctcccagcagact	11	13	2	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:58605192T>G	uc001xdc.2	-	2	996	c.885A>C	c.(883-885)GAA>GAC	p.E295D	C14orf37_uc010tro.1_Missense_Mutation_p.E333D|C14orf37_uc001xdd.2_Missense_Mutation_p.E295D|C14orf37_uc001xde.2_Missense_Mutation_p.E295D	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	295	Extracellular (Potential).					integral to membrane	binding				0						TCACTGTGACTTCTGGGGCTC	0.532													0	0	0	0.00874	0	44	69										G	58605192	T	G	58605192	3	3	69	1	0	0	0	0	1	0	0	0	1771	1606	56	5	1467	5	C14orf37	14	58605192	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	2497334	58605192	48744348	179	21738										
C14orf37	145407	broad.mit.edu	37	chr14	58605935	58605935	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtcatcggtgttcatcttatCggactgccctttttccgcat	8	12	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:58605935C>A	uc001xdc.2	-	2	253	c.142G>T	c.(142-144)GAT>TAT	p.D48Y	C14orf37_uc010tro.1_Missense_Mutation_p.D86Y|C14orf37_uc001xdd.2_Missense_Mutation_p.D48Y|C14orf37_uc001xde.2_Missense_Mutation_p.D48Y	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	48	Extracellular (Potential).					integral to membrane	binding				0						TTCATCTTATCGGACTGCCCT	0.478													1	0	1.42676e-28	0.01441	1.64553e-28	62	106										A	58605935	C	A	58605935	3	1	69	1	0	0	0	0	1	0	0	0	1771	884	31	3	2210	3	C14orf37	14	58605935	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	743	58605935	48743605	180	21739										
ACOT2	10965	broad.mit.edu	37	chr14	74040235	74040235	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aagacctccccaagaccatgGagacgctccatctggagtac	9	14	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:74040235G>C	uc001xon.3	+	2	960	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Missense_Mutation_p.E66Q	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	263					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		CAAGACCATGGAGACGCTCCA	0.488													0	0	0	0.01441	0	60	101										C	74040235	G	C	74040235	3	2	69	1	0	0	0	0	1	0	0	0	152	1175	41	1	793	1	ACOT2	14	74040235	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	15434300	74040235	33309305	181	21740										
ANGEL1	23357	broad.mit.edu	37	chr14	77273074	77273074	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcccgattaagtagctccaaGccaggccggaagtactccac	9	14	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr14:77273074G>T	uc001xsv.2	-	5	1178	c.1065C>A	c.(1063-1065)GGC>GGA	p.G355G	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	355										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		GTAGCTCCAAGCCAGGCCGGA	0.572													1	0	1.73998e-50	0.01441	2.02705e-50	108	130										T	77273074	G	T	77273074	2	4	69	1	0	0	0	0	0	0	0	1	608	958	34	4		4	ANGEL1	14	77273074	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3232839	77273074	30076466	182	21741										
C15orf55	256646	broad.mit.edu	37	chr15	34648800	34648800	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agggcatcccagtgatctgtGggcagaaggttgcttcccat	13	10	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:34648800G>A	uc001zif.2	+	7	2662	c.2507G>A	c.(2506-2508)TGG>TAG	p.W836*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.W864*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.W854*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	836						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AGTGATCTGTGGGCAGAAGGT	0.517			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.00499	0	14	36										A	34648800	G	A	34648800	4	1	69	1	0	0	0	0	0	1	0	0	1803	1357	47	2	2533	2	C15orf55	15	34648800	Nonsense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		34648800	67882592	183	21742										
SLC30A4	7782	broad.mit.edu	37	chr15	45814250	45814250	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctctgcttcagtatctctctCtgtttgctgcagttgtcaca	7	12	5	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:45814250C>T	uc001zvj.2	-	2	615	c.303G>A	c.(301-303)CAG>CAA	p.Q101Q	C15orf21_uc010beg.1_Intron|C15orf21_uc010beh.1_Intron|C15orf21_uc010bei.1_Intron|C15orf21_uc010bej.1_Intron|C15orf21_uc001zvm.1_Intron|C15orf21_uc001zvn.1_Intron	NM_013309	NP_037441	O14863	ZNT4_HUMAN	solute carrier family 30 (zinc transporter),	101	Cytoplasmic (Potential).				regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)		GTATCTCTCTCTGTTTGCTGC	0.478													0	0	0	0.005524	0	36	87										T	45814250	C	T	45814250	2	4	69	1	0	0	0	0	0	0	0	1	14557	912	32	1		1	SLC30A4	15	45814250	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	11165450	45814250	56717142	184	21743										
AP4E1	23431	broad.mit.edu	37	chr15	51289630	51289630	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aatatgacctgttcttccttTagttctttgtcaaatgtggc	7	8	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:51289630T>A	uc001zyx.1	+	18	2484	c.2454T>A	c.(2452-2454)TTT>TTA	p.F818L	AP4E1_uc010bex.1_RNA	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	818					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		GTTCTTCCTTTAGTTCTTTGT	0.353													0	0	0	0.000602	0	4	13										A	51289630	T	A	51289630	3	1	69	1	0	0	0	0	1	0	0	0	752	1751	61	5	2524	5	AP4E1	15	51289630	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	5475380	51289630	51241762	185	21744										
SMAD3	4088	broad.mit.edu	37	chr15	67479786	67479786	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agggctttgaggctgtctacCagttgacccgaatgtgcacc	12	11	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:67479786C>A	uc002aqj.2	+	8	1391	c.1093C>A	c.(1093-1095)CAG>AAG	p.Q365K	SMAD3_uc010ujr.1_Missense_Mutation_p.Q260K|SMAD3_uc010ujs.1_Missense_Mutation_p.Q321K|SMAD3_uc010ujt.1_Missense_Mutation_p.Q170K	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	365	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GGCTGTCTACCAGTTGACCCG	0.557													1	0	6.60958e-23	0.01441	7.52274e-23	59	34										A	67479786	C	A	67479786	3	1	69	1	0	0	0	0	1	0	0	0	14759	595	21	4	1201	4	SMAD3	15	67479786	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	16190156	67479786	35051606	186	21745										
ALPK3	57538	broad.mit.edu	37	chr15	85401422	85401422	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggggaggctctgacaggtctCccggcagctacacctgagga	15	12	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr15:85401422C>T	uc002ble.2	+	6	4226	c.4059C>T	c.(4057-4059)CTC>CTT	p.L1353L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1353					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGACAGGTCTCCCGGCAGCTA	0.642													0	0	0	0.000602	0	3	14										T	85401422	C	T	85401422	2	4	69	1	0	0	0	0	0	0	0	1	546	842	30	1		1	ALPK3	15	85401422	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	17921636	85401422	17129970	187	21746										
USP31	57478	broad.mit.edu	37	chr16	23083506	23083506	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cccagtgttcacacagggaaGaacttgtggagcctgcagag	13	10	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:23083506G>A	uc002dll.2	-	15	2348	c.2348C>T	c.(2347-2349)TCT>TTT	p.S783F	USP31_uc002dlk.2_Missense_Mutation_p.S55F|USP31_uc010vca.1_Missense_Mutation_p.S86F|USP31_uc010bxm.2_Missense_Mutation_p.S71F	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	783	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		ACACAGGGAAGAACTTGTGGA	0.622													0	0	0	0.007413	0	20	27										A	23083506	G	A	23083506	3	1	69	1	0	0	0	0	1	0	0	0	17059	942	33	1	1718	1	USP31	16	23083506	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		23083506	67271247	188	21747										
TNRC6A	27327	broad.mit.edu	37	chr16	24802570	24802570	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aataaccattggggtgaggcCaataagaaatccagctcagg	11	8	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:24802570C>T	uc002dmm.2	+	6	2721	c.2607C>T	c.(2605-2607)GCC>GCT	p.A869A	TNRC6A_uc010bxs.2_Silent_p.A616A|TNRC6A_uc010vcc.1_Silent_p.A616A|TNRC6A_uc002dmn.2_Silent_p.A616A|TNRC6A_uc002dmo.2_Silent_p.A616A	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	869	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GGGGTGAGGCCAATAAGAAAT	0.463													0	0	0	0.000602	0	5	48										T	24802570	C	T	24802570	2	4	69	1	0	0	0	0	0	0	0	1	16337	581	21	2		2	TNRC6A	16	24802570	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1719064	24802570	65552183	189	21748										
APOB48R	55911	broad.mit.edu	37	chr16	28509168	28509168	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gggcagaggccaaggagactGagccagaaagcctggaacat	15	9	0	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:28509168G>C	uc002dqb.1	+	3	2789	c.2779G>C	c.(2779-2781)GAG>CAG	p.E927Q	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.E465Q	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	927	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						CAAGGAGACTGAGCCAGAAAG	0.662													0	0	0	0.001984	0	7	10										C	28509168	G	C	28509168	3	2	69	1	0	0	0	0	1	0	0	0	786	1291	45	1	2789	1	APOB48R	16	28509168	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3706598	28509168	61845585	190	21749										
CORO1A	11151	broad.mit.edu	37	chr16	30199868	30199868	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acaccgggcgcaggagggcaGcaccagaggccagtggcact	16	13	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:30199868G>A	uc002dww.2	+	10	1374	c.1252G>A	c.(1252-1254)GCA>ACA	p.A418T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.A418T|CORO1A_uc010bzr.2_Intron|CORO1A_uc002dwx.2_Missense_Mutation_p.A312T|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	418					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						CAGGAGGGCAGCACCAGAGGC	0.657													0	0	0	0.012319	0	21	16										A	30199868	G	A	30199868	3	1	69	1	0	0	0	0	1	0	0	0	3753	971	34	2	1286	2	CORO1A	16	30199868	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	1690700	30199868	60154885	191	21750										
POLR2C	5432	broad.mit.edu	37	chr16	57504205	57504205	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acctcaggccaaagagtgagTactcggagctggatgaggat	14	8	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:57504205T>C	uc002elt.1	+	8	708	c.622T>C	c.(622-624)TAC>CAC	p.Y208H		NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	208					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						AAAGAGTGAGTACTCGGAGCT	0.547													0	0	0	0.008291	0	10	14										C	57504205	T	C	57504205	3	2	69	1	0	0	0	0	1	0	0	0	12216	1638	57	5	652	5	POLR2C	16	57504205	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	27304337	57504205	32850548	192	21751										
LCAT	3931	broad.mit.edu	37	chr16	67974100	67974109	+	Frame_Shift_Del	DEL	GCAGGCCCAC	GCAGGCCCAC	-													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gatgtaggtgcggggcgtggGcaggcccacgccgtaaagac							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:67974100_67974109delGCAGGCCCAC	uc002euy.1	-	6	1032_1041	c.1021_1030delGTGGGCCTGC	c.(1021-1032)GTGGGCCTGCCCfs	p.V341fs		NM_000229	NP_000220	P04180	LCAT_HUMAN	lecithin-cholesterol acyltransferase precursor	341_344					cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|reverse cholesterol transport|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein A-I binding|phosphatidylcholine-sterol O-acyltransferase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00418)|Epithelial(162;0.0183)|all cancers(182;0.12)		CGGGGCGTGGGCAGGCCCACGCCGTAAAGA	0.61																		30	121	---	---								-	67974109	GCAGGCCCAC	-	67974100	7	5	69	1	0	1	0	1	0	0	0	0	8658	1203	42	0	296	0	LCAT	16	67974100	Frame_Shift_Del	DEL	GCAGGCCCAC	TCGA-E5-A2PC-01A-11D-A202-08	10469895	67974100	22380653	193	21752										
CIRH1A	84916	broad.mit.edu	37	chr16	69199282	69199282	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccagacaaacagtatacagaTtggagccggactgtccagaa	10	10	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:69199282T>C	uc002ews.3	+	15	1782	c.1686T>C	c.(1684-1686)GAT>GAC	p.D562D	CIRH1A_uc002ewr.2_Silent_p.D562D|CIRH1A_uc002ewt.3_Silent_p.D479D|CIRH1A_uc010cfi.2_Silent_p.D364D	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	562	WD 11.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		AGTATACAGATTGGAGCCGGA	0.488													0	0	0	0.003755	0	32	44										C	69199282	T	C	69199282	2	2	69	1	0	0	0	0	0	0	0	1	3434	1490	52	5		5	CIRH1A	16	69199282	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	1225182	69199282	21155471	194	21753										
RFWD3	55159	broad.mit.edu	37	chr16	74695239	74695239	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacatcagcaggaacaggctGgaggagggctggtccccctt	14	12	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:74695239G>A	uc002fda.2	-	2	207	c.109C>T	c.(109-111)CAG>TAG	p.Q37*	RFWD3_uc010cgq.2_Nonsense_Mutation_p.Q37*	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	37					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						GGAACAGGCTGGAGGAGGGCT	0.587													0	0	0	0.01441	0	93	124										A	74695239	G	A	74695239	4	1	69	1	0	0	0	0	0	1	0	0	13261	1357	47	2	2263	2	RFWD3	16	74695239	Nonsense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	5495957	74695239	15659514	195	21754										
CLEC3A	10143	broad.mit.edu	37	chr16	78064707	78064707	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggcctgtcgcagcagcaagaGatacatatgcgagttcacca	11	11	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:78064707G>C	uc002ffh.3	+	3	644	c.563G>C	c.(562-564)AGA>ACA	p.R188T		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	188	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						AGCAGCAAGAGATACATATGC	0.483													0	0	0	0.00308	0	7	41										C	78064707	G	C	78064707	3	2	69	1	0	0	0	0	1	0	0	0	3510	942	33	1	573	1	CLEC3A	16	78064707	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3369468	78064707	12290046	196	21755										
IL17C	27189	broad.mit.edu	37	chr16	88706293	88706293	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctgtgcagaggctgtatcgAtgcacggacgggccgcgaga	16	11	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:88706293A>C	uc002fla.2	+	3	456	c.407A>C	c.(406-408)GAT>GCT	p.D136A		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	136					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		GGCTGTATCGATGCACGGACG	0.687													0	0	0	0.008291	0	11	9										C	88706293	A	C	88706293	3	2	69	1	0	0	0	0	1	0	0	0	7636	333	12	5	417	5	IL17C	16	88706293	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	10641586	88706293	1648460	197	21756										
ZNF778	197320	broad.mit.edu	37	chr16	89294114	89294114	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcatgtaaggactcacactgGagagaaaccatatgaatgta	10	7	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89294114G>C	uc002fmv.2	+	6	1673	c.1334G>C	c.(1333-1335)GGA>GCA	p.G445A	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.G403A|ZNF778_uc010vpg.1_Missense_Mutation_p.G208A	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		ACTCACACTGGAGAGAAACCA	0.493													0	0	0	0.01441	0	52	63										C	89294114	G	C	89294114	3	2	69	1	0	0	0	0	1	0	0	0	18148	1174	41	1	1352	1	ZNF778	16	89294114	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	587821	89294114	1060639	198	21757										
ANKRD11	29123	broad.mit.edu	37	chr16	89346334	89346334	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctttggctcccctgagggctCaggctcgagctctgcaggga	14	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89346334C>G	uc002fmx.1	-	9	7077	c.6616G>C	c.(6616-6618)GAG>CAG	p.E2206Q	ANKRD11_uc002fmy.1_Missense_Mutation_p.E2206Q|ANKRD11_uc002fnc.1_Missense_Mutation_p.E2206Q|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.E2163Q	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2206	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCTGAGGGCTCAGGCTCGAGC	0.672													0	0	0	0.004482	0	8	18										G	89346334	C	G	89346334	3	3	69	1	0	0	0	0	1	0	0	0	639	835	29	1	1395	1	ANKRD11	16	89346334	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	52220	89346334	1008419	199	21758										
ANKRD11	29123	broad.mit.edu	37	chr16	89357082	89357082	+	Silent	SNP	G	G	A													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccctcgctgatgagctctttGatgcgccgggcgtccccgcg							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89357082G>A	uc002fmx.1	-	6	1013	c.552C>T	c.(550-552)ATC>ATT	p.I184I	ANKRD11_uc002fmy.1_Silent_p.I184I|ANKRD11_uc002fnc.1_Silent_p.I184I|ANKRD11_uc002fnd.2_Silent_p.I150I|ANKRD11_uc002fne.2_Silent_p.I150I|ANKRD11_uc002fnb.1_Silent_p.I141I	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	184	ANK 1.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGAGCTCTTTGATGCGCCGGG	0.622													0	0	0	0.01441	0	40	59										A	89357082	G	A	89357082	2	1	69	1	0	0	0	0	0	0	0	1	639	1280	45	1		1	ANKRD11	16	89357082	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	10748	89357082	997671	200	21759	110	2								
ANKRD11	29123	broad.mit.edu	37	chr16	89357086	89357086	+	Missense_Mutation	SNP	C	C	T													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cgctgatgagctctttgatgCgccgggcgtccccgcggatg							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89357086C>T	uc002fmx.1	-	6	1009	c.548G>A	c.(547-549)CGC>CAC	p.R183H	ANKRD11_uc002fmy.1_Missense_Mutation_p.R183H|ANKRD11_uc002fnc.1_Missense_Mutation_p.R183H|ANKRD11_uc002fnd.2_Missense_Mutation_p.R149H|ANKRD11_uc002fne.2_Missense_Mutation_p.R149H|ANKRD11_uc002fnb.1_Missense_Mutation_p.R140H	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	183	ANK 1.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTCTTTGATGCGCCGGGCGTC	0.627													0	0	0	0.01441	0	41	59										T	89357086	C	T	89357086	3	4	69	1	0	0	0	0	1	0	0	0	639	768	27	2	7475	2	ANKRD11	16	89357086	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4	89357086	997667	201	21760	110	2								
FANCA	2175	broad.mit.edu	37	chr16	89857865	89857865	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gggccctccagtgctgcctgGcgcacaaccaggaacgcagt	13	15	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr16:89857865G>C	uc002fou.1	-	14	1347	c.1305C>G	c.(1303-1305)CGC>CGG	p.R435R	FANCA_uc010vpn.1_Silent_p.R435R	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	435			R -> C (in FA).		DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GTGCTGCCTGGCGCACAACCA	0.552			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007413	0	18	18										C	89857865	G	C	89857865	2	2	69	1	0	0	0	0	0	0	0	1	5662	1190	42	4		4	FANCA	16	89857865	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	500779	89857865	496888	202	21761										
MYO1C	4641	broad.mit.edu	37	chr17	1381474	1381474	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcgttgcagtaattgatgcaGaactgctcaaagctgtaagg	11	7	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:1381474G>A	uc002fsp.2	-	12	1528	c.1308C>T	c.(1306-1308)TTC>TTT	p.F436F	MYO1C_uc002fsn.2_Silent_p.F417F|MYO1C_uc002fso.2_Silent_p.F401F|MYO1C_uc010vqj.1_Silent_p.F401F|MYO1C_uc010vqk.1_Silent_p.F412F	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	436	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AATTGATGCAGAACTGCTCAA	0.582													0	0	0	0.009535	0	32	14										A	1381474	G	A	1381474	2	1	69	1	0	0	0	0	0	0	0	1	10070	933	33	1		1	MYO1C	17	1381474	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		1381474	79813736	203	21762										
TP53	7157	broad.mit.edu	37	chr17	7578478	7578478	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggacgcgggtgccgggcgggGgtgtggaatcaacccacagc	19	11	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:7578478G>T	uc002gim.2	-	5	646	c.452C>A	c.(451-453)CCC>CAC	p.P151H	TP53_uc002gig.1_Missense_Mutation_p.P151H|TP53_uc002gih.2_Missense_Mutation_p.P151H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19H|TP53_uc010cng.1_Missense_Mutation_p.P19H|TP53_uc002gii.1_Missense_Mutation_p.P19H|TP53_uc010cnh.1_Missense_Mutation_p.P151H|TP53_uc010cni.1_Missense_Mutation_p.P151H|TP53_uc002gij.2_Missense_Mutation_p.P151H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58H|TP53_uc002gio.2_Missense_Mutation_p.P19H|TP53_uc010vug.1_Missense_Mutation_p.P112H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(8)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P153fs*28(1)|p.D148fs*23(1)|p.P152del(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCGGGCGGGGGTGTGGAATC	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	7.92952e-12	0.003954	8.5738e-12	23	8										T	7578478	G	T	7578478	3	4	69	1	0	0	0	0	1	0	0	0	16378	1232	43	4	846	4	TP53	17	7578478	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	6197004	7578478	73616732	204	21763										
MYH3	4621	broad.mit.edu	37	chr17	10542927	10542927	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaccttggccagggtcaactCaaggtcatcaatgtctttct	8	11	6	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:10542927C>T	uc002gmq.1	-	22	2952	c.2875G>A	c.(2875-2877)GAG>AAG	p.E959K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	959	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						AGGGTCAACTCAAGGTCATCA	0.453													0	0	0	0.01441	0	127	56										T	10542927	C	T	10542927	3	4	69	1	0	0	0	0	1	0	0	0	10036	835	29	1	3023	1	MYH3	17	10542927	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2964449	10542927	70652283	205	21764										
NEK8	284086	broad.mit.edu	37	chr17	27065197	27065197	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agttcatctcgcgtttcctgGagggccagtcgggtgtgacc	14	11	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:27065197G>A	uc002hcp.2	+	8	1156	c.1156G>A	c.(1156-1158)GAG>AAG	p.E386K		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	386						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					GCGTTTCCTGGAGGGCCAGTC	0.657													0	0	0	0.007413	0	16	31										A	27065197	G	A	27065197	3	1	69	1	0	0	0	0	1	0	0	0	10330	1175	41	1	1186	1	NEK8	17	27065197	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	16522270	27065197	54130013	206	21765										
NEK8	284086	broad.mit.edu	37	chr17	27065214	27065214	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ctggagggccagtcgggtgtGaccatcaagcacgtggcctg	16	11	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:27065214G>A	uc002hcp.2	+	8	1173	c.1173G>A	c.(1171-1173)GTG>GTA	p.V391V		NM_178170	NP_835464	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	391						cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|pancreas(1)|liver(1)|skin(1)	6	Lung NSC(42;0.0158)					AGTCGGGTGTGACCATCAAGC	0.642													0	0	0	0.010504	0	19	33										A	27065214	G	A	27065214	2	1	69	1	0	0	0	0	0	0	0	1	10330	1277	45	1		1	NEK8	17	27065214	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	17	27065214	54129996	207	21766										
PSMD11	5717	broad.mit.edu	37	chr17	30800897	30800897	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggcatttgagggttatgactCcatcgacagccccaaggcca	11	12	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:30800897C>G	uc010cta.1	+	7	762	c.722C>G	c.(721-723)TCC>TGC	p.S241C	PSMD11_uc010wbz.1_Missense_Mutation_p.S241C|PSMD11_uc002hhm.2_Missense_Mutation_p.S241C	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	241	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			GGTTATGACTCCATCGACAGC	0.453													0	0	0	0.009096	0	4	73										G	30800897	C	G	30800897	3	3	69	1	0	0	0	0	1	0	0	0	12694	855	30	1	748	1	PSMD11	17	30800897	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	3735683	30800897	50394313	208	21767										
MLLT6	4302	broad.mit.edu	37	chr17	36872640	36872640	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tctcgtccctgcagagctccCctgacttctctgcattcccc	6	19	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:36872640C>G	uc002hqi.3	+	10	1070	c.1057C>G	c.(1057-1059)CCT>GCT	p.P353A	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	353					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GCAGAGCTCCCCTGACTTCTC	0.622			T	MLL	AL								0	0	0	0.007413	0	18	28										G	36872640	C	G	36872640	3	3	69	1	0	0	0	0	1	0	0	0	9630	623	22	4	1095	4	MLLT6	17	36872640	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	6071743	36872640	44322570	209	21768										
KRT39	390792	broad.mit.edu	37	chr17	39116697	39116697	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atcagactctggatctgggtCagcaaggccgtgtagcgagc	14	10	4	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:39116697C>T	uc002hvo.1	-	6	1089	c.1053G>A	c.(1051-1053)CTG>CTA	p.L351L	KRT39_uc010wfm.1_Silent_p.L84L	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	351	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				GGATCTGGGTCAGCAAGGCCG	0.502													0	0	0	0.01441	0	45	85										T	39116697	C	T	39116697	2	4	69	1	0	0	0	0	0	0	0	1	8476	813	29	1		1	KRT39	17	39116697	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2244057	39116697	42078513	210	21769										
CD300LG	146894	broad.mit.edu	37	chr17	41925958	41925958	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tggagggcccagaggaaatcAgcgggttcgaaggggacact	17	8	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:41925958A>T	uc002iem.2	+	2	117	c.76A>T	c.(76-78)AGC>TGC	p.S26C	CD300LG_uc002iek.1_Missense_Mutation_p.S26C|CD300LG_uc002iel.1_Missense_Mutation_p.S26C|CD300LG_uc010czk.2_Missense_Mutation_p.S26C|CD300LG_uc010wil.1_Missense_Mutation_p.S26C|CD300LG_uc010czl.2_Missense_Mutation_p.S26C	NM_145273	NP_660316	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g precursor	26	Extracellular (Potential).|Ig-like V-type.					apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity				0		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		AGAGGAAATCAGCGGGTTCGA	0.562													0	0	0	0.004289	0	35	55										T	41925958	A	T	41925958	3	4	69	1	0	0	0	0	1	0	0	0	3002	188	7	5	82	5	CD300LG	17	41925958	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	2809261	41925958	39269252	211	21770										
GPATCH8	23131	broad.mit.edu	37	chr17	42475276	42475276	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggtgagggtgaatgccgatgGcggcagcagctgcggcagca	19	9	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:42475276G>A	uc002igw.1	-	8	4233	c.4169C>T	c.(4168-4170)GCC>GTC	p.A1390V	GPATCH8_uc002igv.1_Missense_Mutation_p.A1312V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1312V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1390	Poly-Ala.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		AATGCCGATGGCGGCAGCAGC	0.577													0	0	0	0.001984	0	6	38										A	42475276	G	A	42475276	3	1	69	1	0	0	0	0	1	0	0	0	6594	1203	42	2	343	2	GPATCH8	17	42475276	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	549318	42475276	38719934	212	21771										
CLTC	1213	broad.mit.edu	37	chr17	57754351	57754351	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccttggctagaggccagaatTcatgagggctgtgaggagcc	15	9	1	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:57754351T>A	uc002ixq.1	+	17	3041	c.2598T>A	c.(2596-2598)ATT>ATA	p.I866I	CLTC_uc002ixp.2_Silent_p.I866I|CLTC_uc002ixr.1_Silent_p.I870I	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	866	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AGGCCAGAATTCATGAGGGCT	0.408			T	ALK|TFE3	ALCL|renal 								0	0	0	0.00308	0	8	14										A	57754351	T	A	57754351	2	1	69	1	0	0	0	0	0	0	0	1	3566	1771	62	5		5	CLTC	17	57754351	Silent	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	15279075	57754351	23440859	213	21772										
CSH2	1443	broad.mit.edu	37	chr17	61949641	61949641	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtcaaacttgctgtaggtctGcttgaggatctgcccagtcc	11	11	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:61949641G>A	uc002jch.2	-	5	614	c.499C>T	c.(499-501)CAG>TAG	p.Q167*	CSH2_uc002jcg.2_Nonsense_Mutation_p.Q72*|CSH2_uc002jci.2_3'UTR|GH2_uc002jcj.2_Silent_p.S165S|CSH2_uc002jck.2_Nonsense_Mutation_p.Q167*	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	167					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						CTGTAGGTCTGCTTGAGGATC	0.557													0	0	0	0.01441	0	76	106										A	61949641	G	A	61949641	4	1	69	1	0	0	0	0	0	1	0	0	3941	1328	46	2	158	2	CSH2	17	61949641	Nonsense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	4195290	61949641	19245569	214	21773										
CSH2	1443	broad.mit.edu	37	chr17	61950572	61950572	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtgtcaatggccagctggtgCgcgcgatgggcttggagcat	17	9	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:61950572C>T	uc002jch.2	-	2	253	c.138G>A	c.(136-138)GCG>GCA	p.A46A	CSH2_uc002jcg.2_Silent_p.A46A|CSH2_uc002jci.2_Silent_p.A46A|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Silent_p.A46A	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	46					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						CCAGCTGGTGCGCGCGATGGG	0.592													0	0	0	0.006999	0	21	112										T	61950572	C	T	61950572	2	4	69	1	0	0	0	0	0	0	0	1	3941	755	27	2		2	CSH2	17	61950572	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	931	61950572	19244638	215	21774										
SCN4A	6329	broad.mit.edu	37	chr17	62018842	62018842	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcctctgtggccacattgaaGttctccaggatgatggcgat	11	10	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:62018842G>T	uc002jds.1	-	24	4877	c.4800C>A	c.(4798-4800)AAC>AAA	p.N1600K		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1600					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	CCACATTGAAGTTCTCCAGGA	0.532													1	0	1.57351e-24	0.003755	1.79682e-24	33	55										T	62018842	G	T	62018842	3	4	69	1	0	0	0	0	1	0	0	0	13920	1020	36	4	714	4	SCN4A	17	62018842	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	68270	62018842	19176368	216	21775										
PSMD12	5718	broad.mit.edu	37	chr17	65353674	65353674	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agagagagaagggtttcaatGacttcttgaagtcttccttc	10	7	3	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:65353674G>A	uc002jfy.2	-	2	215	c.129C>T	c.(127-129)GTC>GTT	p.V43V	PSMD12_uc002jga.2_Intron|PSMD12_uc002jfz.2_5'UTR|PSMD12_uc010det.1_Silent_p.V43V	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	43					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					GGGTTTCAATGACTTCTTGAA	0.333													0	0	0	0.004289	0	35	139										A	65353674	G	A	65353674	2	1	69	1	0	0	0	0	0	0	0	1	12695	1277	45	1		1	PSMD12	17	65353674	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3334832	65353674	15841536	217	21776										
RNF213	57674	broad.mit.edu	37	chr17	78320135	78320135	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcagctgaatgcctttctctCcaagtccagcgtcagcaaaa	8	13	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:78320135C>G	uc002jyh.1	+	4	2442	c.2219C>G	c.(2218-2220)TCC>TGC	p.S740C		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCCTTTCTCTCCAAGTCCAGC	0.532													0	0	0	0.007413	0	20	59										G	78320135	C	G	78320135	3	3	69	1	0	0	0	0	1	0	0	0	13477	855	30	1	8429	1	RNF213	17	78320135	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	12966461	78320135	2875075	218	21777										
B3GNTL1	146712	broad.mit.edu	37	chr17	81006550	81006550	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gaagttcctacaaaccttacTggcatcattgaaaacagaca	6	10	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr17:81006550T>C	uc002kgg.1	-	2	186	c.172A>G	c.(172-174)AGT>GGT	p.S58G	B3GNTL1_uc002kgf.1_5'UTR	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	58							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			CAAACCTTACTGGCATCATTG	0.507													0	0	0	0.01441	0	49	49										C	81006550	T	C	81006550	3	2	69	1	0	0	0	0	1	0	0	0	1265	1580	55	5	957	5	B3GNTL1	17	81006550	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	2686415	81006550	188660	219	21778										
C18orf8	29919	broad.mit.edu	37	chr18	21110004	21110004	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtcctcagcattacctacatGaacttgttatcaaaaccctt	4	12	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:21110004G>A	uc010xax.1	+	18	1628	c.1507G>A	c.(1507-1509)GAA>AAA	p.E503K	C18orf8_uc002kul.2_RNA|C18orf8_uc010xay.1_Missense_Mutation_p.E127K|NPC1_uc010dlu.1_Intron	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	503	Mic1.									ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TTACCTACATGAACTTGTTAT	0.433													0	0	0	0.01441	0	193	158										A	21110004	G	A	21110004	3	1	69	1	0	0	0	0	1	0	0	0	1907	1291	45	1	1573	1	C18orf8	18	21110004	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		21110004	56967244	220	21779										
MEP1B	4225	broad.mit.edu	37	chr18	29797898	29797898	+	Silent	SNP	C	C	T													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaatatcgtgaaaggatgagCtcaaatcgaccaaatttgac							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:29797898C>T	uc002kxj.3	+	14	2108	c.2061C>T	c.(2059-2061)AGC>AGT	p.S687S		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	687	Cytoplasmic (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						AAAGGATGAGCTCAAATCGAC	0.398													0	0	0	0.000602	0	4	22										T	29797898	C	T	29797898	2	4	69	1	0	0	0	0	0	0	0	1	9476	796	28	2		2	MEP1B	18	29797898	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	8687894	29797898	48279350	221	21780	111	2								
MEP1B	4225	broad.mit.edu	37	chr18	29797900	29797900	+	Nonsense_Mutation	SNP	C	C	A													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atatcgtgaaaggatgagctCaaatcgaccaaatttgactc							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:29797900C>A	uc002kxj.3	+	14	2110	c.2063C>A	c.(2062-2064)TCA>TAA	p.S688*		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	688	Cytoplasmic (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						AGGATGAGCTCAAATCGACCA	0.393													1	0	2.56e-06	0.009096	2.68412e-06	3	22										A	29797900	C	A	29797900	4	1	69	1	0	0	0	0	0	1	0	0	9476	838	29	3	2117	3	MEP1B	18	29797900	Nonsense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2	29797900	48279348	222	21781	111	2								
C18orf22	79863	broad.mit.edu	37	chr18	77802217	77802217	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agggaaatgcagctctagctGaggtaaggttttcaaaaaaa	11	5	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr18:77802217G>A	uc002lns.2	+	5	712	c.574G>A	c.(574-576)GAG>AAG	p.E192K	C18orf22_uc010drh.2_Intron|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_Missense_Mutation_p.E25K	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	192					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		AGCTCTAGCTGAGGTAAGGTT	0.289													0	0	0	0.010729	0	11	24										A	77802217	G	A	77802217	3	1	69	1	0	0	0	0	1	0	0	0	1898	1291	45	1	592	1	C18orf22	18	77802217	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	48004317	77802217	275031	223	21782										
RAX2	84839	broad.mit.edu	37	chr19	3771575	3771575	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggctgccagctcctcacggcTgtacacatccgggtagtgag	13	13	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:3771575T>G	uc002lys.2	-	2	234	c.166A>C	c.(166-168)AGC>CGC	p.S56R	RAX2_uc010dtp.1_RNA|RAX2_uc002lyr.2_Missense_Mutation_p.S102R	NM_032753	NP_116142	Q96IS3	RAX2_HUMAN	retina and anterior neural fold homeobox 2	56	Homeobox.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCACGGCTGTACACATCC	0.637													0	0	0	0.010729	0	12	0										G	3771575	T	G	3771575	3	3	69	1	0	0	0	0	1	0	0	0	13097	1580	55	5	396	5	RAX2	19	3771575	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08		3771575	55357408	224	21783										
PLIN4	729359	broad.mit.edu	37	chr19	4512576	4512576	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cccactgcagacagtgtcctTggtaccagttagaacgatct	9	12	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:4512576T>C	uc002mar.1	-	3	1354	c.1354A>G	c.(1354-1356)AAG>GAG	p.K452E	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	452	11.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						ACAGTGTCCTTGGTACCAGTT	0.577													0	0	0	0.01441	0	91	24										C	4512576	T	C	4512576	3	2	69	1	0	0	0	0	1	0	0	0	12092	1821	63	5	2735	5	PLIN4	19	4512576	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	741001	4512576	54616407	225	21784										
LONP1	9361	broad.mit.edu	37	chr19	5696709	5696709	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgaggatcagggggttctccGtcttggtcttcttcaaacac	11	10	6	1	rs140317309		TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:5696709G>A	uc002mcx.2	-	11	1778	c.1745C>T	c.(1744-1746)ACG>ATG	p.T582M	LONP1_uc002mcy.2_Missense_Mutation_p.T518M|LONP1_uc010duh.2_Missense_Mutation_p.T323M|LONP1_uc010dui.2_Missense_Mutation_p.T566M|LONP1_uc002mcz.2_Missense_Mutation_p.T386M	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	582					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GGGGTTCTCCGTCTTGGTCTT	0.632													0	0	0	0.008361	0	28	10										A	5696709	G	A	5696709	3	1	69	1	0	0	0	0	1	0	0	0	8892	1145	40	2	1166	2	LONP1	19	5696709	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	1184133	5696709	53432274	226	21785										
DNM2	1785	broad.mit.edu	37	chr19	10883300	10883300	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aaccttcgagtctactcgccAcacggtaggcagcacgggtg	12	13	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:10883300A>G	uc002mps.1	+	3	545	c.381A>G	c.(379-381)CCA>CCG	p.P127P	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.P127P|DNM2_uc002mpv.1_Silent_p.P127P|DNM2_uc002mpu.1_Silent_p.P127P|DNM2_uc010dxl.1_Silent_p.P127P	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	127					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TCTACTCGCCACACGGTAGGC	0.562													0	0	0	0.006122	0	17	11										G	10883300	A	G	10883300	2	3	69	1	0	0	0	0	0	0	0	1	4672	146	6	5		5	DNM2	19	10883300	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	5186591	10883300	48245683	227	21786										
CC2D1A	54862	broad.mit.edu	37	chr19	14038827	14038827	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gctggtcattgaccctgtgcCggcagctgtgcccacagtga	13	13	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:14038827C>T	uc002mxo.2	+	23	2737	c.2438C>T	c.(2437-2439)CCG>CTG	p.P813L	CC2D1A_uc002mxp.2_Missense_Mutation_p.P813L|CC2D1A_uc010dzh.2_Missense_Mutation_p.P382L	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	813					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GACCCTGTGCCGGCAGCTGTG	0.637													0	0	0	0.01441	0	52	24										T	14038827	C	T	14038827	3	4	69	1	0	0	0	0	1	0	0	0	2726	652	23	2	2528	2	CC2D1A	19	14038827	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	3155527	14038827	45090156	228	21787										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41770556	41770556	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acgacgagcgggagctcgacGccgacgacgaaccggggcga	17	13	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:41770556G>A	uc002oqb.3	+	1	437	c.148G>A	c.(148-150)GCC>ACC	p.A50T	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Intron|HNRNPUL1_uc002oqa.3_Intron|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.A50T|HNRNPUL1_uc002oqc.3_Intron|HNRNPUL1_uc002oqe.3_Missense_Mutation_p.A50T|HNRNPUL1_uc002oqd.3_5'UTR|HNRNPUL1_uc010ehn.2_5'Flank|HNRNPUL1_uc010eho.2_5'Flank|HNRNPUL1_uc010xvy.1_5'Flank|HNRNPUL1_uc010ehl.1_Intron	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	50	Necessary for interaction with HRMT1L1.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						GGAGCTCGACGCCGACGACGA	0.746													0	0	0	0.001168	0	5	19										A	41770556	G	A	41770556	3	1	69	1	0	0	0	0	1	0	0	0	7274	1087	38	2	150	2	HNRNPUL1	19	41770556	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	27731729	41770556	17358427	229	21788										
C19orf61	56006	broad.mit.edu	37	chr19	44251840	44251840	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cggttctggatctggtacacAggctgtgtgggtctctgccc	14	11	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:44251840A>G	uc002oxj.2	-	4	778	c.435T>C	c.(433-435)CCT>CCC	p.P145P	C19orf61_uc002oxk.2_Silent_p.P145P|C19orf61_uc010eiy.1_Silent_p.P145P	NM_019108	NP_061981	Q9H0W8	SMG9_HUMAN	SMG9 protein	145					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)				TCTGGTACACAGGCTGTGTGG	0.677													0	0	0	0.001168	0	6	18										G	44251840	A	G	44251840	2	3	69	1	0	0	0	0	0	0	0	1	1943	175	7	5		5	C19orf61	19	44251840	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	2481284	44251840	14877143	230	21789										
ERCC2	2068	broad.mit.edu	37	chr19	45855787	45855787	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gtcggcaaagaccatgaggcCgtagtccgtcttgcccctga	12	13	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:45855787C>T	uc002pbj.2	-	21	2070	c.2023G>A	c.(2023-2025)GGC>AGC	p.G675S	ERCC2_uc002pbh.2_Missense_Mutation_p.G238S|ERCC2_uc002pbi.2_Missense_Mutation_p.G368S|ERCC2_uc010ejz.2_Missense_Mutation_p.G597S|ERCC2_uc002pbk.2_Missense_Mutation_p.G651S	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	675			G -> R (in XP-D/CS; severe form).		cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		ACCATGAGGCCGTAGTCCGTC	0.597			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.004878	0	38	44										T	45855787	C	T	45855787	3	4	69	1	0	0	0	0	1	0	0	0	5213	652	23	2	271	2	ERCC2	19	45855787	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1603947	45855787	13273196	231	21790										
EML2	24139	broad.mit.edu	37	chr19	46141892	46141893	+	Splice_Site	DNP	TC	TC	AA													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acattttcacggagccatccTctgccaggacacccccagag							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:46141892_46141893TC>AA	uc002pcn.2	-	3	85	c.50_splice	c.e3-1	p.E17_splice	EML2_uc002pco.2_Splice_Site|EML2_uc002pcp.2_Intron|EML2_uc010xxl.1_Splice_Site_p.E164_splice|EML2_uc010xxm.1_Splice_Site_p.E218_splice|EML2_uc010xxn.1_Splice_Site|EML2_uc010xxo.1_Splice_Site_p.E17_splice|EML2_uc010ekj.2_Splice_Site_p.E17_splice	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like						sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GGAGCCATCCTCTGCCAGGACA	0.559													0	0	0	0.004672	0	22	90										AA	46141893	TC	AA	46141892	5	1	69	1	0	0	0	0	0	0	1	0	5097	1565	54	5	1967	5	EML2	19	46141892	Splice_Site	DNP	TC	TCGA-E5-A2PC-01A-11D-A202-08	286105	46141892	12987091	232	21791										
ZNF320	162967	broad.mit.edu	37	chr19	53384401	53384401	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcttcacatctgtaaggtttCtctccagtgtgaactctacg	7	11	5	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:53384401C>T	uc002qag.2	-	4	1169	c.978G>A	c.(976-978)GAG>GAA	p.E326E	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Silent_p.E272E|ZNF320_uc002qai.2_Silent_p.E326E	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TGTAAGGTTTCTCTCCAGTGT	0.403													0	0	0	0.012319	0	23	43										T	53384401	C	T	53384401	2	4	69	1	0	0	0	0	0	0	0	1	17836	912	32	1		1	ZNF320	19	53384401	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	7242509	53384401	5744582	233	21792										
LAIR2	3904	broad.mit.edu	37	chr19	55014120	55014121	+	Translation_Start_Site	DNP	TC	TC	AA													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcttgtgtctgctgcagagtTctgggaccggggccatgtct							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:55014120_55014121TC>AA	uc002qgc.2	+	1	108_109	c.-14_-13TC>AA	c.(-16--11)GTTCTG>GTAATG		LAIR2_uc002qga.1_Intron|LAIR2_uc002qgb.1_Intron|LAIR2_uc002qgd.2_Translation_Start_Site|LAIR2_uc010erl.2_Translation_Start_Site	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like							extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		GCTGCAGAGTTCTGGGACCGGG	0.629													0	0	0	0.004672	0	11	72										AA	55014121	TC	AA	55014120	1	1	69	1	0	0	0	0	0	0	0	0	8603	1798	62	5		5	LAIR2	19	55014120	Translation_Start_Site	DNP	TC	TCGA-E5-A2PC-01A-11D-A202-08	1629719	55014120	4114863	234	21793										
NLRP9	338321	broad.mit.edu	37	chr19	56243884	56243884	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gcatgaaggcaaaacagtccCctctcctttggaggagtctc	10	12	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr19:56243884C>G	uc002qly.2	-	2	1341	c.1313G>C	c.(1312-1314)GGG>GCG	p.G438A		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	438	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AAAACAGTCCCCTCTCCTTTG	0.483													0	0	0	0.01441	0	73	87										G	56243884	C	G	56243884	3	3	69	1	0	0	0	0	1	0	0	0	10484	623	22	4	1694	4	NLRP9	19	56243884	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1229764	56243884	2885099	235	21794										
RBCK1	10616	broad.mit.edu	37	chr20	389408	389408	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacagccacgccagatggacGagaagaccaagaaaggtggg	14	10	0	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:389408G>A	uc002wdp.3	+	1	700	c.7G>A	c.(7-9)GAG>AAG	p.E3K	RBCK1_uc010zpl.1_Missense_Mutation_p.E3K|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Missense_Mutation_p.R9Q|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_5'UTR|RBCK1_uc002wdo.2_RNA	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	3	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CCAGATGGACGAGAAGACCAA	0.682													0	0	0	0.013537	0	11	8										A	389408	G	A	389408	3	1	69	1	0	0	0	0	1	0	0	0	13107	1059	37	1	28	1	RBCK1	20	389408	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		389408	62636112	236	21795										
SNRPB	6628	broad.mit.edu	37	chr20	2443347	2443347	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccattggagtccctcttccaGgggggatccccattggggga	14	12	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:2443347G>C	uc002wfz.1	-	6	783	c.620C>G	c.(619-621)CCT>CGT	p.P207R	SNRPB_uc002wga.1_Missense_Mutation_p.P207R|SNRPB_uc010zpv.1_Missense_Mutation_p.P128R|SNRPB_uc002wgb.2_Missense_Mutation_p.P207R	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	207	Repeat-rich region.				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						CCCTCTTCCAGGGGGGATCCC	0.587													0	0	0	0.014323	0	24	80										C	2443347	G	C	2443347	3	2	69	1	0	0	0	0	1	0	0	0	14861	1000	35	4	125	4	SNRPB	20	2443347	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	2053939	2443347	60582173	237	21796										
INSM1	3642	broad.mit.edu	37	chr20	20349839	20349839	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcttcagctgcccggccaacCtggcctcgcaccgccgctgg	11	19	2	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:20349839C>G	uc002wrx.2	+	1	1075	c.928C>G	c.(928-930)CTG>GTG	p.L310V		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	310	C2H2-type 2.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		CCCGGCCAACCTGGCCTCGCA	0.577													0	0	0	0.00308	0	7	7										G	20349839	C	G	20349839	3	3	69	1	0	0	0	0	1	0	0	0	7771	680	24	4	930	4	INSM1	20	20349839	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	17906492	20349839	42675681	238	21797										
GDF5	8200	broad.mit.edu	37	chr20	34022485	34022485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccgtgtccgagggcttcttcCgcaagatccgcagctcggcc	12	16	1	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:34022485C>T	uc002xck.1	-	2	1047	c.728G>A	c.(727-729)CGG>CAG	p.R243Q	GDF5_uc010gfc.1_Missense_Mutation_p.R243Q|uc002xcj.2_Missense_Mutation_p.P299L|GDF5_uc010zvc.1_Missense_Mutation_p.R243Q	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	243					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGGCTTCTTCCGCAAGATCCG	0.687													0	0	0	0.008361	0	31	107										T	34022485	C	T	34022485	3	4	69	1	0	0	0	0	1	0	0	0	6316	652	23	2	781	2	GDF5	20	34022485	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	13672646	34022485	29003035	239	21798										
MYBL2	4605	broad.mit.edu	37	chr20	42320809	42320810	+	Missense_Mutation	DNP	TG	TG	CC													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccctgcaggacagacaatgcTgtgaagaatcactggaactc							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:42320809_42320810TG>CC	uc002xlb.1	+	6	728_729	c.513_514TG>CC	c.(511-516)GCTGTG>GCCCTG	p.V172L	MYBL2_uc010zwj.1_Missense_Mutation_p.V148L|MYBL2_uc002xla.1_Missense_Mutation_p.V172L	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	172	HTH myb-type 3.|H-T-H motif (By similarity).					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CAGACAATGCTGTGAAGAATCA	0.337													0	0	0	0.004672	0	37	52										CC	42320810	TG	CC	42320809	3	2	69	1	0	0	0	0	1	0	0	0	10010	1567	55	5	535	5	MYBL2	20	42320809	Missense_Mutation	DNP	TG	TCGA-E5-A2PC-01A-11D-A202-08	8298324	42320809	20704711	240	21799										
WISP2	8839	broad.mit.edu	37	chr20	43355781	43355781	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cccctggtgtcccctgcccaGaatggagcacggcctgggga	14	15	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:43355781G>A	uc002xmn.2	+	5	939	c.586G>A	c.(586-588)GAA>AAA	p.E196K	uc002xml.1_Intron|uc002xmm.1_Intron|WISP2_uc002xmp.2_Missense_Mutation_p.E196K|WISP2_uc002xmq.2_Silent_p.Q113Q	NM_003881	NP_003872	O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	196	TSP type-1.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				CCCCTGCCCAGAATGGAGCAC	0.537													0	0	0	0.01441	0	45	78										A	43355781	G	A	43355781	3	1	69	1	0	0	0	0	1	0	0	0	17370	943	33	1	600	1	WISP2	20	43355781	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	1034972	43355781	19669739	241	21800										
COL9A3	1299	broad.mit.edu	37	chr20	61467685	61467685	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acggggaagccgggagttccGgtacgtcgcttttccggctt	15	11	0	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:61467685G>C	uc002ydm.2	+	28	1551	c.1548G>C	c.(1546-1548)CCG>CCC	p.P516P	COL9A3_uc002ydn.2_5'Flank	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	516	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CGGGAGTTCCGGTACGTCGCT	0.632													0	0	0	0.008361	0	27	43										C	61467685	G	C	61467685	2	2	69	1	0	0	0	0	0	0	0	1	3709	1130	39	4		4	COL9A3	20	61467685	Silent	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	18111904	61467685	1557835	242	21801										
SLC17A9	63910	broad.mit.edu	37	chr20	61597892	61597892	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cacagtggcatttctgttaaCatccaggacttggccccgtc	9	13	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr20:61597892C>T	uc002yea.3	+	11	1261	c.1077C>T	c.(1075-1077)AAC>AAT	p.N359N	SLC17A9_uc002ydz.3_Silent_p.N353N|SLC17A9_uc011aap.1_Silent_p.N379N	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	359					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TTTCTGTTAACATCCAGGACT	0.637													0	0	0	0.004007	0	16	166										T	61597892	C	T	61597892	2	4	69	1	0	0	0	0	0	0	0	1	14424	477	17	2		2	SLC17A9	20	61597892	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	130207	61597892	1427628	243	21802										
ITSN1	6453	broad.mit.edu	37	chr21	35147174	35147174	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agactttggaatttgaattaGaagctctagtgagtgaagtt	11	3	1	5			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:35147174G>C	uc002yta.1	+	13	1715	c.1447G>C	c.(1447-1449)GAA>CAA	p.E483Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E483Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E446Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E483Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E446Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E367Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E483Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E446Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E483Q|ITSN1_uc002ytc.1_Missense_Mutation_p.E483Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E446Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E483Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E417Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	483	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						ATTTGAATTAGAAGCTCTAGT	0.299													0	0	0	0.001855	0	10	40										C	35147174	G	C	35147174	3	2	69	1	0	0	0	0	1	0	0	0	7926	943	33	1	1493	1	ITSN1	21	35147174	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		35147174	12982721	244	21803										
DOPEY2	9980	broad.mit.edu	37	chr21	37665692	37665692	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	caacattctgtttccagcatCaggcagttgatgccattctt	7	11	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:37665692C>T	uc002yvg.2	+	37	6799	c.6720C>T	c.(6718-6720)ATC>ATT	p.I2240I	DOPEY2_uc011aeb.1_Silent_p.I2189I	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2240					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TTTCCAGCATCAGGCAGTTGA	0.458													0	0	0	0.003954	0	27	29										T	37665692	C	T	37665692	2	4	69	1	0	0	0	0	0	0	0	1	4708	816	29	1		1	DOPEY2	21	37665692	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2518518	37665692	10464203	245	21804										
DOPEY2	9980	broad.mit.edu	37	chr21	37665713	37665713	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aggcagttgatgccattcttCatgactctaaatggtgcatt	9	8	3	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:37665713C>T	uc002yvg.2	+	37	6820	c.6741C>T	c.(6739-6741)TTC>TTT	p.F2247F	DOPEY2_uc011aeb.1_Silent_p.F2196F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2247					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TGCCATTCTTCATGACTCTAA	0.478													0	0	0	0.008361	0	31	33										T	37665713	C	T	37665713	2	4	69	1	0	0	0	0	0	0	0	1	4708	825	29	1		1	DOPEY2	21	37665713	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	21	37665713	10464182	246	21805										
BRWD1	54014	broad.mit.edu	37	chr21	40636520	40636520	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atggtggaggcataagatgaGgagcctgctgagtttgctca	15	6	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:40636520G>T	uc002yxk.1	-	17	1890	c.1751C>A	c.(1750-1752)CCT>CAT	p.P584H	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.P584H|BRWD1_uc010goe.1_Intron|BRWD1_uc010gof.1_Missense_Mutation_p.P37H|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_RNA|BRWD1_uc010goi.1_Missense_Mutation_p.P304H	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CATAAGATGAGGAGCCTGCTG	0.393													1	0	4.7546e-09	0.004007	5.09317e-09	17	17										T	40636520	G	T	40636520	3	4	69	1	0	0	0	0	1	0	0	0	1525	1000	35	4	5554	4	BRWD1	21	40636520	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	2970807	40636520	7493375	247	21806										
LCA5L	150082	broad.mit.edu	37	chr21	40783687	40783687	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tgtaaatttttaagtattcgAtgactatagatgtttttaat	6	2	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:40783687A>G	uc002yxu.2	-	7	1330	c.1017T>C	c.(1015-1017)CAT>CAC	p.H339H	LCA5L_uc002yxv.2_Silent_p.H339H	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	339											0		Prostate(19;1.2e-06)				TAAGTATTCGATGACTATAGA	0.294													0	0	0	0.004007	0	14	30										G	40783687	A	G	40783687	2	3	69	1	0	0	0	0	0	0	0	1	8657	330	12	5		5	LCA5L	21	40783687	Silent	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	147167	40783687	7346208	248	21807										
DNMT3L	29947	broad.mit.edu	37	chr21	45666349	45666349	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agggggagaaagcagttcttCaccagcttggtgggccactt	14	9	2	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr21:45666349C>T	uc002zeg.1	-	12	1576	c.1092G>A	c.(1090-1092)GTG>GTA	p.V364V	DNMT3L_uc002zeh.1_Silent_p.V365V	NM_175867	NP_787063	Q9UJW3	DNM3L_HUMAN	cytosine-5-methyltransferase 3-like protein	364					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			skin(2)	2				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AGCAGTTCTTCACCAGCTTGG	0.473													0	0	0	0.006122	0	18	47										T	45666349	C	T	45666349	2	4	69	1	0	0	0	0	0	0	0	1	4678	813	29	1		1	DNMT3L	21	45666349	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4882662	45666349	2463546	249	21808										
CACNA1I	8911	broad.mit.edu	37	chr22	40059831	40059831	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccctggagcggcctcagatCgaggccggcagcaccgtgag	16	14	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr22:40059831C>G	uc003ayc.2	+	19	3582	c.3582C>G	c.(3580-3582)ATC>ATG	p.I1194M	CACNA1I_uc003ayd.2_Missense_Mutation_p.I1159M|CACNA1I_uc003aye.2_Missense_Mutation_p.I1109M|CACNA1I_uc003ayf.2_Missense_Mutation_p.I1074M	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1194	III.|Extracellular (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGCCTCAGATCGAGGCCGGCA	0.622													0	0	0	0.003271	0	30	101										G	40059831	C	G	40059831	3	3	69	1	0	0	0	0	1	0	0	0	2546	874	31	1	3656	1	CACNA1I	22	40059831	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08		40059831	11244735	250	21809										
ENTHD1	150350	broad.mit.edu	37	chr22	40283688	40283688	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggtcgttagaagttgcttccCtgacttttatttcagcatct	8	9	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr22:40283688C>G	uc003ayg.2	-	2	316	c.65G>C	c.(64-66)AGG>ACG	p.R22T		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	22	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					AGTTGCTTCCCTGACTTTTAT	0.388													0	0	0	0.003163	0	15	48										G	40283688	C	G	40283688	3	3	69	1	0	0	0	0	1	0	0	0	5137	681	24	4	1782	4	ENTHD1	22	40283688	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	223857	40283688	11020878	251	21810										
RANGAP1	5905	broad.mit.edu	37	chr22	41652232	41652232	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tccagctcagctttgtctgcCatggcctcagcaacagccag	9	15	3	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chr22:41652232C>T	uc003azs.2	-	8	2421	c.951G>A	c.(949-951)ATG>ATA	p.M317I	RANGAP1_uc003azt.2_Missense_Mutation_p.M317I|RANGAP1_uc003azu.2_Missense_Mutation_p.M317I|RANGAP1_uc011aoz.1_Missense_Mutation_p.M262I	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	317	LRR 5.				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						CTTTGTCTGCCATGGCCTCAG	0.572													0	0	0	0.01441	0	44	57										T	41652232	C	T	41652232	3	4	69	1	0	0	0	0	1	0	0	0	13033	594	21	2	844	2	RANGAP1	22	41652232	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1368544	41652232	9652334	252	21811										
MXRA5	25878	broad.mit.edu	37	chrX	3229321	3229321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccacttcgttaaagtagagtGtcccattgttgaagacgaca	9	9	0	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:3229321G>A	uc004crg.3	-	7	7080	c.6923C>T	c.(6922-6924)ACA>ATA	p.T2308I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2308	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAAGTAGAGTGTCCCATTGTT	0.537													0	0	0	0.01441	0	60	82										A	3229321	G	A	3229321	3	1	69	1	0	0	0	0	1	0	0	0	10003	1377	48	2	1567	2	MXRA5	23	3229321	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08		3229321	152041239	253	21812										
MXRA5	25878	broad.mit.edu	37	chrX	3239768	3239768	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aatttcttttccatctgatgTgggtttatatgtgactggaa	9	5	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:3239768T>A	uc004crg.3	-	5	4115	c.3958A>T	c.(3958-3960)ACA>TCA	p.T1320S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1320						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCATCTGATGTGGGTTTATAT	0.363													0	0	0	0.004656	0	26	131										A	3239768	T	A	3239768	3	1	69	1	0	0	0	0	1	0	0	0	10003	1696	59	5	4540	5	MXRA5	23	3239768	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	10447	3239768	152030792	254	21813										
TLR7	51284	broad.mit.edu	37	chrX	12904760	12904760	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctgaaaattctgcggatcaGaggatatgtctttaaagagt	10	6	3	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:12904760G>C	uc004cvc.2	+	3	1272	c.1133G>C	c.(1132-1134)AGA>ACA	p.R378T		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	378	Extracellular (Potential).|LRR 13.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CTGCGGATCAGAGGATATGTC	0.338													0	0	0	0.001855	0	14	83										C	12904760	G	C	12904760	3	2	69	1	0	0	0	0	1	0	0	0	15953	942	33	1	1139	1	TLR7	23	12904760	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	9664992	12904760	142365800	255	21814										
TLR7	51284	broad.mit.edu	37	chrX	12905270	12905270	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	agcagagctgagatatttggActtctccaacaaccggcttg	10	10	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:12905270A>T	uc004cvc.2	+	3	1782	c.1643A>T	c.(1642-1644)GAC>GTC	p.D548V		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	548	Extracellular (Potential).|LRR 18.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AGATATTTGGACTTCTCCAAC	0.388													0	0	0	0.01441	0	98	174										T	12905270	A	T	12905270	3	4	69	1	0	0	0	0	1	0	0	0	15953	275	10	5	1649	5	TLR7	23	12905270	Missense_Mutation	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	510	12905270	142365290	256	21815										
PIR	8544	broad.mit.edu	37	chrX	15509315	15509315	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccaatgcttctccggaccctCgctccaaccccttccgactg	6	20	1	0			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:15509315C>T	uc004cwu.2	-	2	304	c.66G>A	c.(64-66)GCG>GCA	p.A22A	PIR_uc004cwv.2_Silent_p.A22A|BMX_uc004cww.2_Intron	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	22					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					TCCGGACCCTCGCTCCAACCC	0.522													0	0	0	0.01441	0	93	117										T	15509315	C	T	15509315	2	4	69	1	0	0	0	0	0	0	0	1	11944	871	31	1		1	PIR	23	15509315	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2604045	15509315	139761245	257	21816										
ZRSR2	8233	broad.mit.edu	37	chrX	15821884	15821884	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tcagaataaagaaggaaaagGaagaggcggctaaaaaacgg	13	4	1	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:15821884G>A	uc004cxg.3	+	4	322	c.277G>A	c.(277-279)GAA>AAA	p.E93K		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	93					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					GAAGGAAAAGGAAGAGGCGGC	0.378													0	0	0	0.009096	0	4	13										A	15821884	G	A	15821884	3	1	69	1	0	0	0	0	1	0	0	0	18222	1175	41	1	291	1	ZRSR2	23	15821884	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	312569	15821884	139448676	258	21817										
CDKL5	6792	broad.mit.edu	37	chrX	18643279	18643279	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cgacagccctgatcttctgaCgttgcagaaatccattcatt	7	12	3	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:18643279C>A	uc004cym.2	+	17	2661	c.2408C>A	c.(2407-2409)ACG>AAG	p.T803K	CDKL5_uc004cyn.2_Missense_Mutation_p.T803K	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	803					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					GATCTTCTGACGTTGCAGAAA	0.483													1	0	6.25564e-26	0.01441	7.16706e-26	62	84										A	18643279	C	A	18643279	3	1	69	1	0	0	0	0	1	0	0	0	3157	536	19	4	2470	4	CDKL5	23	18643279	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	2821395	18643279	136627281	259	21818										
RPS6KA3	6197	broad.mit.edu	37	chrX	20205975	20205975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	accaaaagaccaccagtcagCactctgagtatgacctcgac	7	14	2	3			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:20205975C>T	uc004czu.2	-	9	745	c.745G>A	c.(745-747)GCT>ACT	p.A249T	RPS6KA3_uc011mjk.1_Missense_Mutation_p.A220T|RPS6KA3_uc004czv.2_Missense_Mutation_p.A237T|RPS6KA3_uc011mjl.1_Missense_Mutation_p.A221T|RPS6KA3_uc011mjm.1_Missense_Mutation_p.A221T	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	249	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						CACCAGTCAGCACTCTGAGTA	0.393													0	0	0	0.00874	0	41	71										T	20205975	C	T	20205975	3	4	69	1	0	0	0	0	1	0	0	0	13652	710	25	2	1533	2	RPS6KA3	23	20205975	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1562696	20205975	135064585	260	21819										
KDM6A	7403	broad.mit.edu	37	chrX	44969392	44969392	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	aagacctacatagtacattgCcaagattgtgcacgaaaaac	7	9	0	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:44969392C>A	uc004dge.3	+	28	4449	c.4074C>A	c.(4072-4074)TGC>TGA	p.C1358*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.C1410*|KDM6A_uc011mla.1_Nonsense_Mutation_p.C1313*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.C1365*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.C1062*|KDM6A_uc011mld.1_Nonsense_Mutation_p.C997*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1358					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGTACATTGCCAAGATTGTG	0.368			D|N|F|S		renal|oesophageal SCC|MM								1	0	7.93312e-07	0.00245	8.34304e-07	14	34										A	44969392	C	A	44969392	4	1	69	1	0	0	0	0	0	1	0	0	8137	747	26	4	4184	4	KDM6A	23	44969392	Nonsense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	24763417	44969392	110301168	261	21820										
FOXP3	50943	broad.mit.edu	37	chrX	49107796	49107796	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	cctttccttgatcttgaggtCaggggccaggtgtagggttg	15	8	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:49107796C>G	uc004dnf.3	-	12	1483	c.1295G>C	c.(1294-1296)TGA>TCA	p.*432S	FOXP3_uc011mnb.1_Nonstop_Mutation_p.*455S|FOXP3_uc011mnc.1_Nonstop_Mutation_p.*405S|FOXP3_uc004dne.3_Nonstop_Mutation_p.*397S|FOXP3_uc010niq.1_3'UTR	NM_014009	NP_054728	Q9BZS1	FOXP3_HUMAN	forkhead box P3 isoform a	432					B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding				0	Ovarian(276;0.236)					ATCTTGAGGTCAGGGGCCAGG	0.617													0	0	0	0.008291	0	9	23										G	49107796	C	G	49107796	4	3	69	1	0	0	0	0	0	0	0	0	6028	837	29	1	4	1	FOXP3	23	49107796	Nonstop_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	4138404	49107796	106162764	262	21821										
ZXDB	158586	broad.mit.edu	37	chrX	57619922	57619922	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	acaaaagaaagcacgacgatGaccggaggttcatgtgccct	11	10	1	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:57619922G>A	uc004dvd.2	+	1	1654	c.1441G>A	c.(1441-1443)GAC>AAC	p.D481N		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	481	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						GCACGACGATGACCGGAGGTT	0.517													0	0	0	0.01441	0	53	76										A	57619922	G	A	57619922	3	1	69	1	0	0	0	0	1	0	0	0	18248	1290	45	1	1443	1	ZXDB	23	57619922	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	8512126	57619922	97650638	263	21822										
LAS1L	81887	broad.mit.edu	37	chrX	64734785	64734785	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ggtgtcataattctccagcaTgagctctgctgggtcctcgg	12	11	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:64734785T>A	uc004dwa.1	-	13	2068	c.1996A>T	c.(1996-1998)ATG>TTG	p.M666L	LAS1L_uc004dwc.1_Missense_Mutation_p.M649L|LAS1L_uc004dwd.1_Missense_Mutation_p.M607L|LAS1L_uc004dvy.1_Missense_Mutation_p.M179L|LAS1L_uc004dvz.1_Missense_Mutation_p.M179L	NM_031206	NP_112483	Q9Y4W2	LAS1L_HUMAN	LAS1-like	666						MLL1 complex|nucleolus	protein binding			ovary(3)|large_intestine(1)	4						TTCTCCAGCATGAGCTCTGCT	0.557													0	0	0	0.013537	0	13	22										A	64734785	T	A	64734785	3	1	69	1	0	0	0	0	1	0	0	0	8636	1464	51	5	216	5	LAS1L	23	64734785	Missense_Mutation	SNP	T	TCGA-E5-A2PC-01A-11D-A202-08	7114863	64734785	90535775	264	21823										
OGT	8473	broad.mit.edu	37	chrX	70784453	70784453	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	atttttttcttgttctagatCaacaataaggctgcaactgg	7	7	3	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:70784453C>A	uc004eaa.1	+	19	2656	c.2439C>A	c.(2437-2439)ATC>ATA	p.I813I	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.I803I|OGT_uc004eac.2_Silent_p.I674I|OGT_uc004ead.2_Silent_p.I432I	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	813					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TGTTCTAGATCAACAATAAGG	0.383													1	0	3.32936e-07	0.006122	3.53361e-07	17	22										A	70784453	C	A	70784453	2	1	69	1	0	0	0	0	0	0	0	1	10847	816	29	3		3	OGT	23	70784453	Silent	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	6049668	70784453	84486107	265	21824										
STAG2	10735	broad.mit.edu	37	chrX	123182853	123182853	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gaaatgatgtgtttttttacAgcttcaggaaaatcaagatg	9	4	2	2			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:123182853A>C	uc004etz.3	+	9	1159	c.820_splice	c.e9-2	p.L274_splice	STAG2_uc004eua.2_Splice_Site_p.L274_splice|STAG2_uc004eub.2_Splice_Site_p.L274_splice|STAG2_uc004euc.2_Splice_Site_p.L274_splice|STAG2_uc004eud.2_Splice_Site_p.L274_splice|STAG2_uc004eue.2_Splice_Site_p.L274_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GTTTTTTTACAGCTTCAGGAA	0.308													0	0	0	0.00278	0	24	26										C	123182853	A	C	123182853	5	2	69	1	0	0	0	0	0	0	1	0	15242	202	7	5	848	5	STAG2	23	123182853	Splice_Site	SNP	A	TCGA-E5-A2PC-01A-11D-A202-08	52398400	123182853	32087707	266	21825										
MAGEC2	51438	broad.mit.edu	37	chrX	141291023	141291024	+	Nonsense_Mutation	DNP	CC	CC	TT													0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	ccctactgcattcagcacttCccagatgacctcctcagagg							TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:141291023_141291024CC>TT	uc004fbu.1	-	3	1098_1099	c.750_751GG>AA	c.(748-753)TGGGAA>TGAAAA	p.250_251WE>*K		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	250_251	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAGCACTTCCCAGATGACCT	0.515										HNSCC(46;0.14)			0	0	0	0.004672	0	59	129										TT	141291024	CC	TT	141291023	4	4	69	1	0	0	0	0	0	1	0	0	9181	864	30	1	374	1	MAGEC2	23	141291023	Nonsense_Mutation	DNP	CC	TCGA-E5-A2PC-01A-11D-A202-08	18108170	141291023	13979537	267	21826										
SPANXN2	494119	broad.mit.edu	37	chrX	142803727	142803727	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gattcacaggggctcttcctCttctccccattggtgcttga	9	13	4	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:142803727C>A	uc004fbz.2	-	1	790	c.36G>T	c.(34-36)AAG>AAT	p.K12N		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	12										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTCTTCCTCTTCTCCCCAT	0.318													1	0	2.165e-29	0.01441	2.50532e-29	58	205										A	142803727	C	A	142803727	3	1	69	1	0	0	0	0	1	0	0	0	14991	912	32	3	514	3	SPANXN2	23	142803727	Missense_Mutation	SNP	C	TCGA-E5-A2PC-01A-11D-A202-08	1512704	142803727	12466833	268	21827										
MTM1	4534	broad.mit.edu	37	chrX	149809841	149809841	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	tggttccgtatcgtgcctcaGatgatgacctccggagagtt	12	10	1	4			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:149809841G>T	uc004fef.3	+	8	704	c.628G>T	c.(628-630)GAT>TAT	p.D210Y	MTM1_uc011mxx.1_RNA|MTM1_uc011mxy.1_Missense_Mutation_p.D173Y|MTM1_uc011mxz.1_Missense_Mutation_p.D95Y|MTM1_uc010nte.2_Missense_Mutation_p.D78Y	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	210	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCGTGCCTCAGATGATGACCT	0.438													1	0	3.86212e-05	0.008291	4.01289e-05	10	54										T	149809841	G	T	149809841	3	4	69	1	0	0	0	0	1	0	0	0	9937	942	33	3	654	3	MTM1	23	149809841	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	7006114	149809841	5460719	269	21828										
PNCK	139728	broad.mit.edu	37	chrX	152937346	152937346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.232209737827715	62	2.99886258207388e-13	2.66097350003932	2.41221890029897	2.76884053886478	2.8192529054064e-06	2.8192529054064e-05	39	gccaggcaccttgaggtcccGgtgcacgatccccaggctgt	13	15	0	1			TCGA-E5-A2PC-01A-11D-A202-08	TCGA-E5-A2PC-10B-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62b9f71c-2dab-455a-a454-579e8843f712	bad04664-6ccb-4b10-addf-357be540b43e	g.chrX:152937346G>A	uc011myu.1	-	5	838	c.652C>T	c.(652-654)CGG>TGG	p.R218W	PNCK_uc011myt.1_Missense_Mutation_p.R152W|PNCK_uc004fia.2_Missense_Mutation_p.R147W|PNCK_uc004fhz.3_Missense_Mutation_p.R33W|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_Missense_Mutation_p.R162W|PNCK_uc011myw.1_Missense_Mutation_p.R162W	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	135	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGAGGTCCCGGTGCACGATC	0.662													0	0	0	0.001168	0	6	18										A	152937346	G	A	152937346	3	1	69	1	0	0	0	0	1	0	0	0	12145	1115	39	2	656	2	PNCK	23	152937346	Missense_Mutation	SNP	G	TCGA-E5-A2PC-01A-11D-A202-08	3127505	152937346	2333214	270	21829										
TNFRSF4	7293	broad.mit.edu	37	chr1	1149375	1149375	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggcctcacctggcctgcactCgtggcagcaccggtcgttgc	13	16	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:1149375C>T	uc001ade.2	-	1	138	c.133G>A	c.(133-135)GAG>AAG	p.E45K	TNFRSF4_uc001adf.2_5'UTR	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	45	Extracellular (Potential).|TNFR-Cys 1.				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGCCTGCACTCGTGGCAGCAC	0.721													0	0	0	0.004672	0	3	5										T	1149375	C	T	1149375	3	4	70	1	0	0	0	0	1	0	0	0	16294	893	31	1	728	1	TNFRSF4	1	1149375	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		1149375	248101246	1	21830										
CASZ1	54897	broad.mit.edu	37	chr1	10713996	10713996	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttggcgcccagcagcgagggCggcagccccagcgcgcccga	16	17	0	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:10713996C>T	uc001aro.2	-	11	2438	c.2118G>A	c.(2116-2118)CCG>CCA	p.P706P	CASZ1_uc001arp.1_Silent_p.P706P|CASZ1_uc009vmx.2_Silent_p.P730P	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCAGCGAGGGCGGCAGCCCCA	0.667													0	0	0	0.028581	0	17	49										T	10713996	C	T	10713996	2	4	70	1	0	0	0	0	0	0	0	1	2685	755	27	2		2	CASZ1	1	10713996	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	9564621	10713996	238536625	2	21831										
DNAJC16	23341	broad.mit.edu	37	chr1	15860766	15860766	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	acaaagatcctggagcagaaGacaagttcattcaaatcagt	8	8	3	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:15860766G>A	uc001aws.2	+	3	322	c.202G>A	c.(202-204)GAC>AAC	p.D68N	DNAJC16_uc001awr.1_Missense_Mutation_p.D68N|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	68	Cytoplasmic (Potential).|J.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TGGAGCAGAAGACAAGTTCAT	0.413													0	0	0	0.048971	0	48	46										A	15860766	G	A	15860766	3	1	70	1	0	0	0	0	1	0	0	0	4635	942	33	1	208	1	DNAJC16	1	15860766	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	5146770	15860766	233389855	3	21832										
DNAJC16	23341	broad.mit.edu	37	chr1	15863024	15863024	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	atcaatatggagacgctggaGagaaccagggctaccagaag	13	8	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:15863024G>C	uc001aws.2	+	4	409	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	DNAJC16_uc001awr.1_Missense_Mutation_p.E97Q|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	97	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGACGCTGGAGAGAACCAGGG	0.363													0	0	0	0.037714	0	31	29										C	15863024	G	C	15863024	3	2	70	1	0	0	0	0	1	0	0	0	4635	943	33	1	299	1	DNAJC16	1	15863024	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	2258	15863024	233387597	4	21833										
RSC1A1	6248	broad.mit.edu	37	chr1	15986519	15986519	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gatcgcattgaacctaaagcTgtgaaggctttgaaggcttc	11	8	0	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:15986519T>C	uc010obn.1	+	1	156	c.156T>C	c.(154-156)GCT>GCC	p.A52A	DDI2_uc001awx.1_3'UTR|DDI2_uc009voj.1_3'UTR	NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	52					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AACCTAAAGCTGTGAAGGCTT	0.448													0	0	0	0.048971	0	154	179										C	15986519	T	C	15986519	2	2	70	1	0	0	0	0	0	0	0	1	13698	1567	55	5		5	RSC1A1	1	15986519	Silent	SNP	T	TCGA-E7-A3X6-01A-12D-A22Z-08	123495	15986519	233264102	5	21834										
ARHGEF10L	55160	broad.mit.edu	37	chr1	17942675	17942675	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtgatgcgcaaagtctccttCctgcacaggaaggacgtcct	11	12	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:17942675C>T	uc001ban.2	+	9	972	c.813C>T	c.(811-813)TTC>TTT	p.F271F	ARHGEF10L_uc009vpe.1_Silent_p.F232F|ARHGEF10L_uc001bao.2_Silent_p.F232F|ARHGEF10L_uc001bap.2_Silent_p.F232F|ARHGEF10L_uc010ocr.1_Silent_p.F29F|ARHGEF10L_uc001baq.2_Silent_p.F37F|ARHGEF10L_uc010ocs.1_5'Flank|ARHGEF10L_uc001bar.2_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	271					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AAGTCTCCTTCCTGCACAGGA	0.622													0	0	0	0.054565	0	33	71										T	17942675	C	T	17942675	2	4	70	1	0	0	0	0	0	0	0	1	895	854	30	1		1	ARHGEF10L	1	17942675	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	1956156	17942675	231307946	6	21835										
LUZP1	7798	broad.mit.edu	37	chr1	23418794	23418794	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	catctgagtctggcttctctCtgccactggatttgatgact	9	11	4	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23418794C>G	uc001bgk.2	-	4	2345	c.1961G>C	c.(1960-1962)AGA>ACA	p.R654T	LUZP1_uc010odv.1_Missense_Mutation_p.R654T|LUZP1_uc001bgl.2_Missense_Mutation_p.R654T|LUZP1_uc001bgm.1_Missense_Mutation_p.R654T	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	654						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TGGCTTCTCTCTGCCACTGGA	0.483													0	0	0	0.048971	0	79	166										G	23418794	C	G	23418794	3	3	70	1	0	0	0	0	1	0	0	0	9086	913	32	1	1277	1	LUZP1	1	23418794	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	5476119	23418794	225831827	7	21836			1	96		4	4	1136	N	T_C	2.144936e-08
LUZP1	7798	broad.mit.edu	37	chr1	23418882	23418882	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgcaggttgattaaccccttCtttatgtgaggttgaaaatc	9	7	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23418882C>T	uc001bgk.2	-	4	2257	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	LUZP1_uc010odv.1_Missense_Mutation_p.E625K|LUZP1_uc001bgl.2_Missense_Mutation_p.E625K|LUZP1_uc001bgm.1_Missense_Mutation_p.E625K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	625						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTAACCCCTTCTTTATGTGAG	0.468													0	0	0	0.048971	0	80	160										T	23418882	C	T	23418882	3	4	70	1	0	0	0	0	1	0	0	0	9086	922	32	1	1365	1	LUZP1	1	23418882	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	88	23418882	225831739	8	21837			1	96		4	4	1136	N	T_C	2.144936e-08
LUZP1	7798	broad.mit.edu	37	chr1	23419916	23419916	+	Frame_Shift_Del	DEL	T	T	-													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgttgtcttcctgattgcggTtcttttcattttctgatttg							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23419916delT	uc001bgk.2	-	4	1223	c.839delA	c.(838-840)AACfs	p.N280fs	LUZP1_uc010odv.1_Frame_Shift_Del_p.N280fs|LUZP1_uc001bgl.2_Frame_Shift_Del_p.N280fs|LUZP1_uc001bgm.1_Frame_Shift_Del_p.N280fs	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	280	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		CTGATTGCGGTTCTTTTCATT	0.393																		23	94	---	---								-	23419916	T	-	23419916	7	5	70	1	0	1	0	1	0	0	0	0	9086	1725	60	0	2399	0	LUZP1	1	23419916	Frame_Shift_Del	DEL	T	TCGA-E7-A3X6-01A-12D-A22Z-08	1034	23419916	225830705	9	21838			1	96		4	4	1136	N	T_C	2.144936e-08
LUZP1	7798	broad.mit.edu	37	chr1	23419929	23419929	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	attgcggttcttttcattttCtgatttgtttcttgtttcat	6	6	5	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:23419929C>T	uc001bgk.2	-	4	1210	c.826G>A	c.(826-828)GAA>AAA	p.E276K	LUZP1_uc010odv.1_Missense_Mutation_p.E276K|LUZP1_uc001bgl.2_Missense_Mutation_p.E276K|LUZP1_uc001bgm.1_Missense_Mutation_p.E276K	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	276	Potential.					nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		TTTTCATTTTCTGATTTGTTT	0.403													0	0	0	0.045705	0	7	74										T	23419929	C	T	23419929	3	4	70	1	0	0	0	0	1	0	0	0	9086	922	32	1	2412	1	LUZP1	1	23419929	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	13	23419929	225830692	10	21839			1	96		4	4	1136	N	T_C	2.144936e-08
GPN2	54707	broad.mit.edu	37	chr1	27212601	27212601	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtaggagaggtccagaacctCtgtgtagtagtccaggttga	14	7	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:27212601C>G	uc001bnd.1	-	3	874	c.592G>C	c.(592-594)GAG>CAG	p.E198Q		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	198							GTP binding				0						TCCAGAACCTCTGTGTAGTAG	0.502													0	0	0	0.020292	0	15	38										G	27212601	C	G	27212601	3	3	70	1	0	0	0	0	1	0	0	0	6618	922	32	1	352	1	GPN2	1	27212601	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	3792672	27212601	222038020	11	21840										
TMEM54	113452	broad.mit.edu	37	chr1	33363847	33363847	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	agggcagctgtgatgaagctCacatggcccagcaccaccag	12	13	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:33363847C>G	uc001bwi.1	-	2	204	c.90G>C	c.(88-90)GTG>GTC	p.V30V	TMEM54_uc001bwj.1_Silent_p.V30V|TMEM54_uc001bwk.1_Silent_p.V30V	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	30	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGATGAAGCTCACATGGCCCA	0.612													0	0	0	0.076483	0	23	64										G	33363847	C	G	33363847	2	3	70	1	0	0	0	0	0	0	0	1	16177	813	29	1		1	TMEM54	1	33363847	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	6151246	33363847	215886774	12	21841										
TMEM54	113452	broad.mit.edu	37	chr1	33363913	33363913	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttccggaagtcgcccacactCaggcctcctgtgggggacag	13	14	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:33363913C>T	uc001bwi.1	-	2	138	c.24G>A	c.(22-24)CTG>CTA	p.L8L	TMEM54_uc001bwj.1_Silent_p.L8L|TMEM54_uc001bwk.1_Silent_p.L8L	NM_033504	NP_277039	Q969K7	TMM54_HUMAN	transmembrane protein 54	8						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CGCCCACACTCAGGCCTCCTG	0.617													0	0	0	0.105934	0	12	43										T	33363913	C	T	33363913	2	4	70	1	0	0	0	0	0	0	0	1	16177	813	29	1		1	TMEM54	1	33363913	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	66	33363913	215886708	13	21842										
CD58	965	broad.mit.edu	37	chr1	117078651	117078651	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttaaataatggattgctaagAgtacactgtattttttgtgg	9	3	0	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:117078651A>T	uc001egm.2	-	3	685	c.564T>A	c.(562-564)ACT>ACA	p.T188T	CD58_uc001egn.2_RNA|CD58_uc010owy.1_Silent_p.T188T|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Silent_p.T188T	NM_001779	NP_001770	P19256	LFA3_HUMAN	CD58 molecule isoform 1	188	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		GATTGCTAAGAGTACACTGTA	0.343													0	0	0	0.014758	0	5	118										T	117078651	A	T	117078651	2	4	70	1	0	0	0	0	0	0	0	1	3025	291	11	5		5	CD58	1	117078651	Silent	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	83714738	117078651	132171970	14	21843										
CHD1L	9557	broad.mit.edu	37	chr1	146747112	146747112	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgcaagcagctgccagggctCatcgcattggccaaaacaag	11	12	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:146747112C>A	uc001epm.3	+	13	1429	c.1366C>A	c.(1366-1368)CAT>AAT	p.H456N	uc001epp.2_Intron|CHD1L_uc001epn.3_Missense_Mutation_p.H343N|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.H362N|CHD1L_uc010ozp.1_Missense_Mutation_p.H175N|CHD1L_uc001epo.3_Missense_Mutation_p.H252N|CHD1L_uc010ozq.1_Missense_Mutation_p.H29N|CHD1L_uc009wji.2_Missense_Mutation_p.H175N	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	456	Helicase C-terminal.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					TGCCAGGGCTCATCGCATTGG	0.443													1	0	2.02796e-37	0.048971	2.19171e-37	69	72										A	146747112	C	A	146747112	3	1	70	1	0	0	0	0	1	0	0	0	3324	826	29	3	1416	3	CHD1L	1	146747112	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	29668461	146747112	102503509	15	21844										
MTMR11	10903	broad.mit.edu	37	chr1	149903264	149903264	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtgttcgggcttcgggggctGaaagcagctggacgagtgaa	18	7	0	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:149903264G>A	uc001etl.3	-	13	1429	c.1178C>T	c.(1177-1179)TCA>TTA	p.S393L	MTMR11_uc001etm.1_Missense_Mutation_p.S321L|MTMR11_uc010pbm.1_Intron|MTMR11_uc010pbn.1_Silent_p.F219F	NM_001145862	NP_001139334	A4FU01	MTMRB_HUMAN	myotubularin related protein 11 isoform a	393	Myotubularin phosphatase.						phosphatase activity			central_nervous_system(1)	1	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TTCGGGGGCTGAAAGCAGCTG	0.562													0	0	0	0.09836	0	41	66										A	149903264	G	A	149903264	3	1	70	1	0	0	0	0	1	0	0	0	9940	1294	45	1	1010	1	MTMR11	1	149903264	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	3156152	149903264	99347357	16	21845										
ZNF687	57592	broad.mit.edu	37	chr1	151262304	151262304	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cgtcttcatcttcagaagagGaggaagtacccagctcccct	9	13	4	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:151262304G>A	uc001exq.2	+	6	2883	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K	ZNF687_uc009wmo.2_Missense_Mutation_p.E929K|ZNF687_uc009wmp.2_Missense_Mutation_p.E929K	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	929	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCAGAAGAGGAGGAAGTACC	0.657													0	0	0	0.02938	0	6	3										A	151262304	G	A	151262304	3	1	70	1	0	0	0	0	1	0	0	0	18089	1175	41	1	2803	1	ZNF687	1	151262304	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	1359040	151262304	97988317	17	21846										
SMG5	23381	broad.mit.edu	37	chr1	156242175	156242175	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gcctgccagggtgcccagctGattgaagggcattcctaggg	15	11	0	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:156242175G>A	uc001foc.3	-	7	798	c.649C>T	c.(649-651)CAG>TAG	p.Q217*		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	217					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					GTGCCCAGCTGATTGAAGGGC	0.493													0	0	0	0.021553	0	5	20										A	156242175	G	A	156242175	4	1	70	1	0	0	0	0	0	1	0	0	14796	1299	45	1	2465	1	SMG5	1	156242175	Nonsense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	4979871	156242175	93008446	18	21847										
SMG5	23381	broad.mit.edu	37	chr1	156243158	156243158	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tggggacaacttaccaatctGaggagctactgacagggctt	12	9	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:156243158G>C	uc001foc.3	-	6	777	c.628C>G	c.(628-630)CAG>GAG	p.Q210E		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	210					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TTACCAATCTGAGGAGCTACT	0.478													0	0	0	0.0918	0	23	54										C	156243158	G	C	156243158	3	2	70	1	0	0	0	0	1	0	0	0	14796	1299	45	1	2490	1	SMG5	1	156243158	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	983	156243158	93007463	19	21848										
HMCN1	83872	broad.mit.edu	37	chr1	186106714	186106714	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccaaaagaggagtcgtctgtGcaaccagccccttccagcca	9	15	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:186106714G>A	uc001grq.1	+	88	13896	c.13667G>A	c.(13666-13668)TGC>TAC	p.C4556Y	HMCN1_uc001grs.1_Missense_Mutation_p.C125Y	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4556	TSP type-1 1.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGTCGTCTGTGCAACCAGCCC	0.488													0	0	0	0.037714	0	29	37										A	186106714	G	A	186106714	3	1	70	1	0	0	0	0	1	0	0	0	7220	1319	46	2	14017	2	HMCN1	1	186106714	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	29863556	186106714	63143907	20	21849										
TRAF3IP3	80342	broad.mit.edu	37	chr1	209933433	209933433	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctggcttggcccggtgggctGagagctatgaggccaagtgt	17	9	0	2	rs150331171		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:209933433G>A	uc001hho.2	+	3	339	c.49G>A	c.(49-51)GAG>AAG	p.E17K	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.E17K|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.E17K|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.E17K|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.E17K	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	17	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CCGGTGGGCTGAGAGCTATGA	0.622													0	0	0	0.038395	0	17	33										A	209933433	G	A	209933433	3	1	70	1	0	0	0	0	1	0	0	0	16439	1291	45	1	51	1	TRAF3IP3	1	209933433	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	23826719	209933433	39317188	21	21850										
ZP4	57829	broad.mit.edu	37	chr1	238053473	238053473	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gctcgtgcagcagcccttggTtgtctggaggggtggggaag	19	8	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:238053473T>G	uc001hym.2	-	2	179	c.179A>C	c.(178-180)AAC>ACC	p.N60T	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	60	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CAGCCCTTGGTTGTCTGGAGG	0.562													0	0	0	0.048971	0	53	56										G	238053473	T	G	238053473	3	3	70	1	0	0	0	0	1	0	0	0	18215	1725	60	5	1487	5	ZP4	1	238053473	Missense_Mutation	SNP	T	TCGA-E7-A3X6-01A-12D-A22Z-08	28120040	238053473	11197148	22	21851										
WDR64	128025	broad.mit.edu	37	chr1	241951205	241951205	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tattttggacagcgaaggctCtttgaattatcacagacaag	9	7	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr1:241951205C>G	uc001hzf.1	+	13	1542	c.1389C>G	c.(1387-1389)CTC>CTG	p.L463L	WDR64_uc001hzg.1_Silent_p.L376L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	910										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AGCGAAGGCTCTTTGAATTAT	0.383													0	0	0	0.048971	0	77	105										G	241951205	C	G	241951205	2	3	70	1	0	0	0	0	0	0	0	1	17312	900	32	1		1	WDR64	1	241951205	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	3897732	241951205	7299416	23	21852										
ASXL2	55252	broad.mit.edu	37	chr2	25990544	25990544	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aggaagaaaagctggagtttGagttttgagggctgcctgtc	15	5	0	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:25990544G>C	uc002rgs.2	-	7	904	c.683C>G	c.(682-684)TCA>TGA	p.S228*	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	228	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGGAGTTTGAGTTTTGAGG	0.413													0	0	0	0.069456	0	36	47										C	25990544	G	C	25990544	4	2	70	1	0	0	0	0	0	1	0	0	1067	1294	45	1	3648	1	ASXL2	2	25990544	Nonsense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		25990544	217208829	24	21853										
NCKAP5	344148	broad.mit.edu	37	chr2	133542927	133542927	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttggaactgcttggagcaatGctaaggtggaagggtcatcg	15	6	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:133542927G>A	uc002ttp.2	-	14	1831	c.1457C>T	c.(1456-1458)GCA>GTA	p.A486V	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	486							protein binding				0						TTGGAGCAATGCTAAGGTGGA	0.498													0	0	0	0.069456	0	35	79										A	133542927	G	A	133542927	3	1	70	1	0	0	0	0	1	0	0	0	10223	1319	46	2	4300	2	NCKAP5	2	133542927	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	107552383	133542927	109656446	25	21854										
TTN	7273	broad.mit.edu	37	chr2	179393575	179393575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	attcagtacccatttcacatCagtggcaccagcaatgttgg	8	11	3	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:179393575C>T	uc010zfg.1	-	309	99423	c.99199G>A	c.(99199-99201)GAT>AAT	p.D33067N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D26762N|TTN_uc010zfi.1_Missense_Mutation_p.D26695N|TTN_uc010zfj.1_Missense_Mutation_p.D26570N|TTN_uc002umq.2_Missense_Mutation_p.D84N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33994							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTCACATCAGTGGCACCA	0.453													0	0	0	0.055883	0	20	34										T	179393575	C	T	179393575	3	4	70	1	0	0	0	0	1	0	0	0	16732	826	29	1	1088	1	TTN	2	179393575	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	45850648	179393575	63805798	26	21855										
TTN	7273	broad.mit.edu	37	chr2	179430575	179430575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tggaacaccaactccaaattCattttcagccatgactctga	5	12	3	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:179430575C>T	uc010zfg.1	-	275	72804	c.72580G>A	c.(72580-72582)GAA>AAA	p.E24194K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17889K|TTN_uc010zfi.1_Missense_Mutation_p.E17822K|TTN_uc010zfj.1_Missense_Mutation_p.E17697K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25121							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCAAATTCATTTTCAGCC	0.433													0	0	0	0.048971	0	73	187										T	179430575	C	T	179430575	3	4	70	1	0	0	0	0	1	0	0	0	16732	835	29	1	27843	1	TTN	2	179430575	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	37000	179430575	63768798	27	21856										
IKZF2	22807	broad.mit.edu	37	chr2	213872226	213872226	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgtacatgacatggtctaggAaaaggactcggcagtgctca	12	8	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:213872226A>G	uc002vem.2	-	8	1608	c.1439T>C	c.(1438-1440)TTC>TCC	p.F480S	IKZF2_uc010fuu.2_Missense_Mutation_p.F335S|IKZF2_uc002vej.2_Missense_Mutation_p.F427S|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.F406S|IKZF2_uc002vel.2_Missense_Mutation_p.F401S|IKZF2_uc010fuw.2_Missense_Mutation_p.F254S|IKZF2_uc010fux.2_Missense_Mutation_p.F254S|IKZF2_uc010fuy.2_Missense_Mutation_p.F408S|IKZF2_uc002ven.2_Missense_Mutation_p.F454S|IKZF2_uc002vei.2_Missense_Mutation_p.F258S	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	480	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		ATGGTCTAGGAAAAGGACTCG	0.512													0	0	0	0.055883	0	19	119										G	213872226	A	G	213872226	3	3	70	1	0	0	0	0	1	0	0	0	7615	246	9	5	145	5	IKZF2	2	213872226	Missense_Mutation	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	34441651	213872226	29327147	28	21857										
RNPEPL1	57140	broad.mit.edu	37	chr2	241514466	241514466	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggagtgaatcccagccacctGatgaacctgttcacctacga	9	13	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr2:241514466G>T	uc002vzi.2	+	7	1208	c.615G>T	c.(613-615)CTG>CTT	p.L205L	RNPEPL1_uc010fzf.2_Silent_p.L111L|RNPEPL1_uc002vzj.2_5'Flank	NM_018226	NP_060696	Q9HAU8	RNPL1_HUMAN	arginyl aminopeptidase (aminopeptidase B)-like	205					leukotriene biosynthetic process|proteolysis		aminopeptidase activity|metallopeptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2		all_epithelial(40;1.13e-11)|Breast(86;0.000169)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.204)|Melanoma(123;0.238)		Epithelial(32;3.05e-31)|all cancers(36;8.2e-29)|OV - Ovarian serous cystadenocarcinoma(60;8.55e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.12e-06)|Lung(119;0.00168)|Colorectal(34;0.005)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.0322)		CCAGCCACCTGATGAACCTGT	0.587													1	0	3.41278e-10	0.0333	3.51375e-10	15	112										T	241514466	G	T	241514466	2	4	70	1	0	0	0	0	0	0	0	1	13510	1277	45	3		3	RNPEPL1	2	241514466	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	27642240	241514466	1684907	29	21858										
LRRN1	57633	broad.mit.edu	37	chr3	3886477	3886477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	taccccacagtcaacttacaGagaagccaccactgttgatt	6	13	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:3886477G>A	uc003bpt.3	+	2	913	c.152G>A	c.(151-153)AGA>AAA	p.R51K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	51	LRRNT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCAACTTACAGAGAAGCCACC	0.438													0	0	0	0.080422	0	37	92										A	3886477	G	A	3886477	3	1	70	1	0	0	0	0	1	0	0	0	9034	942	33	1	154	1	LRRN1	3	3886477	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		3886477	194135953	30	21859										
IL17RC	84818	broad.mit.edu	37	chr3	9974314	9974314	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	atccacaagcgctgggccctCgtgtggctggcctgcctact	12	15	0	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:9974314C>T	uc003bua.2	+	17	1859	c.1623C>T	c.(1621-1623)CTC>CTT	p.L541L	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_Silent_p.L470L|IL17RC_uc011atp.1_Silent_p.L309L|IL17RC_uc003bud.2_Silent_p.L11L|IL17RC_uc003bub.2_Silent_p.L455L|IL17RC_uc010hct.2_Silent_p.L470L|IL17RC_uc010hcu.2_Silent_p.L453L|IL17RC_uc010hcv.2_Silent_p.L438L|IL17RC_uc011atq.1_Silent_p.L455L|IL17RC_uc003buc.2_Silent_p.L11L|IL17RC_uc003bue.2_Silent_p.L106L|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank|CRELD1_uc003buj.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	541	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GCTGGGCCCTCGTGTGGCTGG	0.532											OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.054565	0	32	77										T	9974314	C	T	9974314	2	4	70	1	0	0	0	0	0	0	0	1	7641	871	31	1		1	IL17RC	3	9974314	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	6087837	9974314	188048116	31	21860										
SMARCC1	6599	broad.mit.edu	37	chr3	47717003	47717003	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggagtaaatgtcagtacggaGaccaaagttctgcaaatcaa	10	7	3	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:47717003G>C	uc003crq.2	-	18	1919	c.1801C>G	c.(1801-1803)CTC>GTC	p.L601V	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.L492V	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	601					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TCAGTACGGAGACCAAAGTTC	0.378													0	0	0	0.038395	0	16	36										C	47717003	G	C	47717003	3	2	70	1	0	0	0	0	1	0	0	0	14775	942	33	1	1560	1	SMARCC1	3	47717003	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	37742689	47717003	150305427	32	21861										
IP6K2	51447	broad.mit.edu	37	chr3	48732710	48732710	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggctccacatccatggccctGaaggctgggctcatcctccg	11	16	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:48732710G>A	uc003cup.2	-	2	259	c.15C>T	c.(13-15)TTC>TTT	p.F5F	IP6K2_uc003cuq.2_Silent_p.F5F|IP6K2_uc011bbq.1_Silent_p.F5F|IP6K2_uc011bbr.1_Silent_p.F5F|IP6K2_uc003cur.2_Silent_p.F5F|IP6K2_uc003cus.2_Silent_p.F5F|IP6K2_uc003cut.2_RNA|IP6K2_uc011bbs.1_RNA|IP6K2_uc011bbt.1_Silent_p.F60F|IP6K2_uc003cuv.1_Nonsense_Mutation_p.Q131*|IP6K2_uc011bbu.1_Silent_p.F59F|IP6K2_uc011bbv.1_Silent_p.F63F|IP6K2_uc003cuw.1_Nonsense_Mutation_p.Q130*	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	5					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						CCATGGCCCTGAAGGCTGGGC	0.637													0	0	0	0.069288	0	24	26										A	48732710	G	A	48732710	2	1	70	1	0	0	0	0	0	0	0	1	7789	1281	45	1		1	IP6K2	3	48732710	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	1015707	48732710	149289720	33	21862										
ACTR8	93973	broad.mit.edu	37	chr3	53907147	53907147	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	actcatggtcctgaagcccaGagatgtcctgattccaggaa	10	11	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:53907147G>A	uc003dhd.2	-	9	1132	c.1073C>T	c.(1072-1074)TCT>TTT	p.S358F	ACTR8_uc003dhb.2_Missense_Mutation_p.S63F|ACTR8_uc003dhc.2_Missense_Mutation_p.S247F	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	358					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CTGAAGCCCAGAGATGTCCTG	0.418													0	0	0	0.080935	0	10	14										A	53907147	G	A	53907147	3	1	70	1	0	0	0	0	1	0	0	0	217	942	33	1	821	1	ACTR8	3	53907147	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	5174437	53907147	144115283	34	21863										
OR5H14	403273	broad.mit.edu	37	chr3	97868522	97868522	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gatatctctctctgaatgcaAgatacagttgttttcgtttg	8	7	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:97868522A>C	uc003dsg.1	+	1	293	c.293A>C	c.(292-294)AAG>ACG	p.K98T		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTGAATGCAAGATACAGTTG	0.383													0	0	0	0.048971	0	100	202										C	97868522	A	C	97868522	3	2	70	1	0	0	0	0	1	0	0	0	11160	72	3	5	295	5	OR5H14	3	97868522	Missense_Mutation	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	43961375	97868522	100153908	35	21864										
CASR	846	broad.mit.edu	37	chr3	121980624	121980624	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aactcatctcccagtactctGatgaggaagagatccagcat	8	11	3	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:121980624G>C	uc003eev.3	+	4	1114	c.742G>C	c.(742-744)GAT>CAT	p.D248H	CASR_uc003eew.3_Missense_Mutation_p.D248H	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	248	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCAGTACTCTGATGAGGAAGA	0.502													0	0	0	0.048971	0	60	157										C	121980624	G	C	121980624	3	2	70	1	0	0	0	0	1	0	0	0	2682	1290	45	1	752	1	CASR	3	121980624	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	24112102	121980624	76041806	36	21865										
PLXND1	23129	broad.mit.edu	37	chr3	129303367	129303367	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	caggccatctccatgccactGaggctgggcaggctgcccga	13	15	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:129303367G>C	uc003emx.2	-	6	1990	c.1890C>G	c.(1888-1890)CTC>CTG	p.L630L		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	630	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CCATGCCACTGAGGCTGGGCA	0.637													0	0	0	0.074837	0	38	54										C	129303367	G	C	129303367	2	2	70	1	0	0	0	0	0	0	0	1	12127	1277	45	1		1	PLXND1	3	129303367	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	7322743	129303367	68719063	37	21866										
PAQR9	344838	broad.mit.edu	37	chr3	142681210	142681210	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tctacgtagtacacctggtcGtagatgctgaggaaggtgaa	13	7	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr3:142681210G>A	uc003evg.2	-	1	969	c.969C>T	c.(967-969)TAC>TAT	p.Y323Y	PAQR9_uc003evf.1_RNA	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	323	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						ACACCTGGTCGTAGATGCTGA	0.597													0	0	0	0.069234	0	11	108										A	142681210	G	A	142681210	2	1	70	1	0	0	0	0	0	0	0	1	11442	1140	40	2		2	PAQR9	3	142681210	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	13377843	142681210	55341220	38	21867										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.076483	0	22	9										G	1803568	C	G	1803568	3	3	70	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		1803568	189350708	39	21868										
GABRA4	2557	broad.mit.edu	37	chr4	46967082	46967082	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccttttggctttttccatttGaatattggtgaaatagttga	8	5	0	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:46967082G>C	uc003gxg.2	-	8	1178	c.1039C>G	c.(1039-1041)CAA>GAA	p.Q347E		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	347	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTTCCATTTGAATATTGGTG	0.478													0	0	0	0.099896	0	26	68										C	46967082	G	C	46967082	3	2	70	1	0	0	0	0	1	0	0	0	6163	1299	45	1	633	1	GABRA4	4	46967082	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	45163514	46967082	144187194	40	21869										
AASDH	132949	broad.mit.edu	37	chr4	57220365	57220365	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	catcatcaagaaaacacactCtgtttctgccaccttcccaa	3	15	4	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr4:57220365C>G	uc003hbn.2	-	8	1376	c.1223G>C	c.(1222-1224)AGA>ACA	p.R408T	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.R255T|AASDH_uc003hbo.2_Missense_Mutation_p.R308T|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Missense_Mutation_p.R408T|AASDH_uc003hbp.2_Missense_Mutation_p.R408T	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	408					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				AAAACACACTCTGTTTCTGCC	0.373													0	0	0	0.09319	0	12	51										G	57220365	C	G	57220365	3	3	70	1	0	0	0	0	1	0	0	0	22	913	32	1	2105	1	AASDH	4	57220365	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	10253283	57220365	133933911	41	21870										
RASA1	5921	broad.mit.edu	37	chr5	86672272	86672272	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccacagatgaatggtttctgCtcagctcccatataccatta	6	12	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr5:86672272C>G	uc003kiw.2	+	16	2192	c.2074C>G	c.(2074-2076)CTC>GTC	p.L692V	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.L515V|RASA1_uc011ctv.1_Missense_Mutation_p.L525V|RASA1_uc011ctw.1_Missense_Mutation_p.L526V|RASA1_uc010jaw.2_Missense_Mutation_p.L514V	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	692					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		ATGGTTTCTGCTCAGCTCCCA	0.423													0	0	0	0.080935	0	12	17										G	86672272	C	G	86672272	3	3	70	1	0	0	0	0	1	0	0	0	13060	797	28	4	2148	4	RASA1	5	86672272	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		86672272	94242988	42	21871										
PCDHB1	29930	broad.mit.edu	37	chr5	140432013	140432013	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aaacatacgacattgacattCaagctacagatggtggaggc	10	8	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr5:140432013C>T	uc003lik.1	+	1	1035	c.958C>T	c.(958-960)CAA>TAA	p.Q320*		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	320	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTGACATTCAAGCTACAGA	0.473													0	0	0	0.048971	0	52	42										T	140432013	C	T	140432013	4	4	70	1	0	0	0	0	0	1	0	0	11534	827	29	1	960	1	PCDHB1	5	140432013	Nonsense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	53759741	140432013	40483247	43	21872										
MSH5	4439	broad.mit.edu	37	chr6	31712335	31712335	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtcctcaggactcatctggtGaacatagatcaagacactta	8	10	4	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:31712335G>A	uc003nwv.1	+	8	739	c.660G>A	c.(658-660)GTG>GTA	p.V220V	MSH5_uc003nwt.1_Silent_p.V237V|MSH5_uc003nwu.1_Silent_p.V220V|MSH5_uc003nww.1_Silent_p.V220V|MSH5_uc003nwx.1_Silent_p.V237V|MSH5_uc011dof.1_5'UTR	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	220					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CTCATCTGGTGAACATAGATC	0.463								Direct_reversal_of_damage|MMR					0	0	0	0.059317	0	33	49										A	31712335	G	A	31712335	2	1	70	1	0	0	0	0	0	0	0	1	9873	1277	45	1		1	MSH5	6	31712335	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		31712335	139402732	44	21873										
EEF1A1	1915	broad.mit.edu	37	chr6	74229695	74229696	+	Frame_Shift_Ins	INS	-	-	CGAATCTA													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccagtagtggtggacttgccINScgaatctacgtgtccaatga							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:74229695_74229696insCGAATCTA	uc003phi.2	-	1	91_92	c.54_55insTAGATTCG	c.(52-57)TCGGGCfs	p.S18fs	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phf.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phg.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phk.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phl.2_Frame_Shift_Ins_p.S18fs|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	18_19	GTP (By similarity).					cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						GTGGACTTGCCCGAATCTACGT	0.416																		25	76	---	---								CGAATCTA	74229696	-	CGAATCTA	74229695	7	5	70	1	0	1	1	0	0	0	0	0	4923	623	22	0	1361	0	EEF1A1	6	74229695	Frame_Shift_Ins	INS	-	TCGA-E7-A3X6-01A-12D-A22Z-08	42517360	74229695	96885372	45	21874										
EEF1A1	1915	broad.mit.edu	37	chr6	74229729	74229729	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccaatgacgacaatgttgatAtgagtcttttcctttcccat	6	10	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:74229729A>G	uc003phi.2	-	1	58	c.21T>C	c.(19-21)CAT>CAC	p.H7H	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Silent_p.H7H|EEF1A1_uc003phf.2_Silent_p.H7H|EEF1A1_uc003phg.2_Silent_p.H7H|EEF1A1_uc003phh.2_5'UTR|EEF1A1_uc003phj.2_Silent_p.H7H|EEF1A1_uc003phk.2_Silent_p.H7H|EEF1A1_uc003phl.2_Silent_p.H7H|EEF1A1_uc003phm.1_RNA	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	7						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						CAATGTTGATATGAGTCTTTT	0.423													0	0	0	0.034045	0	31	52										G	74229729	A	G	74229729	2	3	70	1	0	0	0	0	0	0	0	1	4923	446	16	5		5	EEF1A1	6	74229729	Silent	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	34	74229729	96885338	46	21875										
ZNF292	23036	broad.mit.edu	37	chr6	87967337	87967337	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtgaatgttgcaaataacttCagtagcaccaatgcccaaca	7	10	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:87967337C>T	uc003plm.3	+	8	4031	c.3990C>T	c.(3988-3990)TTC>TTT	p.F1330F		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CAAATAACTTCAGTAGCACCA	0.428													0	0	0	0.014758	0	5	12										T	87967337	C	T	87967337	2	4	70	1	0	0	0	0	0	0	0	1	17823	825	29	1		1	ZNF292	6	87967337	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	13737608	87967337	83147730	47	21876										
TIAM2	26230	broad.mit.edu	37	chr6	155566797	155566797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aggctctttcctttattacgCggaccactttaaactgtaca	6	11	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:155566797C>T	uc003qqb.2	+	21	4857	c.3584C>T	c.(3583-3585)GCG>GTG	p.A1195V	TIAM2_uc003qqe.2_Missense_Mutation_p.A1195V|TIAM2_uc010kjj.2_Missense_Mutation_p.A728V|TIAM2_uc003qqf.2_Missense_Mutation_p.A571V|TIAM2_uc011efl.1_Missense_Mutation_p.A531V|TIAM2_uc003qqg.2_Missense_Mutation_p.A507V|TIAM2_uc003qqh.2_Missense_Mutation_p.A120V	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1195	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTTTATTACGCGGACCACTTT	0.403													0	0	0	0.048971	0	86	217										T	155566797	C	T	155566797	3	4	70	1	0	0	0	0	1	0	0	0	15888	768	27	2	3646	2	TIAM2	6	155566797	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	67599460	155566797	15548270	48	21877										
SNX9	51429	broad.mit.edu	37	chr6	158330750	158330750	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	acctctacttttgactgtgtGgtagcagatcccaggaaagg	11	9	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr6:158330750G>C	uc003qqv.1	+	8	932	c.759G>C	c.(757-759)GTG>GTC	p.V253V		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	253	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		TTGACTGTGTGGTAGCAGATC	0.393													0	0	0	0.041601	0	32	77										C	158330750	G	C	158330750	2	2	70	1	0	0	0	0	0	0	0	1	14909	1335	47	4		4	SNX9	6	158330750	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	2763953	158330750	12784317	49	21878										
POLD2	5425	broad.mit.edu	37	chr7	44157603	44157603	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tggccttgaacagagtgcccAccacacagcacttctcctca	7	16	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:44157603A>T	uc010kxz.2	-	4	931	c.281T>A	c.(280-282)GTG>GAG	p.V94E	POLD2_uc003tke.3_Missense_Mutation_p.V94E|POLD2_uc010kya.2_Missense_Mutation_p.V94E|POLD2_uc003tkf.3_Missense_Mutation_p.V94E	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	94					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						CAGAGTGCCCACCACACAGCA	0.622													0	0	0	0.064281	0	37	59										T	44157603	A	T	44157603	3	4	70	1	0	0	0	0	1	0	0	0	12191	159	6	5	1164	5	POLD2	7	44157603	Missense_Mutation	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08		44157603	114981060	50	21879										
AUTS2	26053	broad.mit.edu	37	chr7	70255358	70255358	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	atgacccccttcatgggcatCagccccctcccgggcggaga	11	17	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:70255358C>T	uc003tvw.3	+	19	3899	c.3156C>T	c.(3154-3156)ATC>ATT	p.I1052I	AUTS2_uc003tvx.3_Silent_p.I1028I|AUTS2_uc011keg.1_Silent_p.I504I	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1052										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TCATGGGCATCAGCCCCCTCC	0.622													0	0	0	0.02938	0	6	23										T	70255358	C	T	70255358	2	4	70	1	0	0	0	0	0	0	0	1	1225	816	29	1		1	AUTS2	7	70255358	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	26097755	70255358	88883305	51	21880										
HEPACAM2	253012	broad.mit.edu	37	chr7	92848628	92848628	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tatttgggcattgtgtggggTctctcaaatagccatatgat	11	6	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:92848628T>A	uc003umm.2	-	2	239	c.216A>T	c.(214-216)AGA>AGT	p.R72S	HEPACAM2_uc003uml.2_Missense_Mutation_p.R60S|HEPACAM2_uc010lff.2_Missense_Mutation_p.R60S|HEPACAM2_uc011khy.1_Missense_Mutation_p.R95S	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	72	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TTGTGTGGGGTCTCTCAAATA	0.498													0	0	0	0.041601	0	32	60										A	92848628	T	A	92848628	3	1	70	1	0	0	0	0	1	0	0	0	7053	1664	58	5	1208	5	HEPACAM2	7	92848628	Missense_Mutation	SNP	T	TCGA-E7-A3X6-01A-12D-A22Z-08	22593270	92848628	66290035	52	21881										
ASB4	51666	broad.mit.edu	37	chr7	95165854	95165854	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gaagagctatccccgatgatGacttggaggtaaataatcga	11	7	0	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:95165854G>A	uc011kij.1	+	4	1084	c.1084G>A	c.(1084-1086)GAC>AAC	p.D362N		NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	362					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CCCCGATGATGACTTGGAGGT	0.388													0	0	0	0.105934	0	13	37										A	95165854	G	A	95165854	3	1	70	1	0	0	0	0	1	0	0	0	1025	1290	45	1	1170	1	ASB4	7	95165854	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	2317226	95165854	63972809	53	21882										
LMTK2	22853	broad.mit.edu	37	chr7	97821587	97821587	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttgaggagtccagtacagatGaggacttcttccaaagcagt	11	8	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:97821587G>C	uc003upd.1	+	11	2103	c.1810G>C	c.(1810-1812)GAG>CAG	p.E604Q		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	604					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CAGTACAGATGAGGACTTCTT	0.517													0	0	0	0.043863	0	19	39										C	97821587	G	C	97821587	3	2	70	1	0	0	0	0	1	0	0	0	8859	1291	45	1	1852	1	LMTK2	7	97821587	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	2655733	97821587	61317076	54	21883										
MLL5	55904	broad.mit.edu	37	chr7	104730618	104730618	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gaaaaagatacacaaaatcaGaatattactttggattgtga	7	4	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104730618G>A	uc003vcm.2	+	14	2055	c.1521G>A	c.(1519-1521)CAG>CAA	p.Q507Q	MLL5_uc010lja.1_Silent_p.Q361Q|MLL5_uc010ljb.1_Silent_p.Q507Q|MLL5_uc003vcl.2_Silent_p.Q507Q|MLL5_uc010ljc.2_Silent_p.Q507Q|MLL5_uc003vco.1_RNA|MLL5_uc010ljd.1_3'UTR	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	507					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CACAAAATCAGAATATTACTT	0.328													0	0	0	0.034045	0	30	65										A	104730618	G	A	104730618	2	1	70	1	0	0	0	0	0	0	0	1	9624	933	33	1		1	MLL5	7	104730618	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	6909031	104730618	54408045	55	21884			2	97		4	3	1138	N	G	1.27906e-05
MLL5	55904	broad.mit.edu	37	chr7	104731737	104731737	+	Silent	SNP	G	G	A													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gaaatggaatcagaggagcaGattgcagaaaggaaaaggaa							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104731737G>A	uc003vcm.2	+	15	2232	c.1698G>A	c.(1696-1698)CAG>CAA	p.Q566Q	MLL5_uc003vcl.2_Silent_p.Q566Q|MLL5_uc010ljc.2_Silent_p.Q566Q	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	566	Potential.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						CAGAGGAGCAGATTGCAGAAA	0.378													0	0	0	0.058154	0	5	28										A	104731737	G	A	104731737	2	1	70	1	0	0	0	0	0	0	0	1	9624	933	33	1		1	MLL5	7	104731737	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	1119	104731737	54406926	56	21885	112	2	2	97		4	3	1138	N	G	1.27906e-05
MLL5	55904	broad.mit.edu	37	chr7	104731744	104731744	+	Missense_Mutation	SNP	G	G	A													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aatcagaggagcagattgcaGaaaggaaaaggaagatggta							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104731744G>A	uc003vcm.2	+	15	2239	c.1705G>A	c.(1705-1707)GAA>AAA	p.E569K	MLL5_uc003vcl.2_Missense_Mutation_p.E569K|MLL5_uc010ljc.2_Missense_Mutation_p.E569K	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	569	Potential.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCAGATTGCAGAAAGGAAAAG	0.383													0	0	0	0.058154	0	4	27										A	104731744	G	A	104731744	3	1	70	1	0	0	0	0	1	0	0	0	9624	943	33	1	1755	1	MLL5	7	104731744	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	7	104731744	54406919	57	21886	112	2	2	97		4	3	1138	N	G	1.27906e-05
MLL5	55904	broad.mit.edu	37	chr7	104731755	104731755	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cagattgcagaaaggaaaagGaagatggtaagttgggaagc	15	3	0	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:104731755G>A	uc003vcm.2	+	15	2250	c.1716G>A	c.(1714-1716)AGG>AGA	p.R572R	MLL5_uc003vcl.2_Silent_p.R572R|MLL5_uc010ljc.2_Silent_p.R572R	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	572	Potential.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AAAGGAAAAGGAAGATGGTAA	0.373													0	0	0	0.038147	0	4	23										A	104731755	G	A	104731755	2	1	70	1	0	0	0	0	0	0	0	1	9624	1165	41	1		1	MLL5	7	104731755	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	11	104731755	54406908	58	21887			2	97		4	3	1138	N	G	1.27906e-05
OR6V1	346517	broad.mit.edu	37	chr7	142750161	142750161	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctttctccacttgcgggtctCacctcacactggtcttcatc	6	16	5	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr7:142750161C>A	uc011ksv.1	+	1	724	c.724C>A	c.(724-726)CAC>AAC	p.H242N		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TTGCGGGTCTCACCTCACACT	0.552													1	0	1.07234e-20	0.048971	1.15178e-20	50	120										A	142750161	C	A	142750161	3	1	70	1	0	0	0	0	1	0	0	0	11211	826	29	3	726	3	OR6V1	7	142750161	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	38018406	142750161	16388502	59	21888										
UBR5	51366	broad.mit.edu	37	chr8	103357737	103357737	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	taatgacacttgggtgggcaGaatgaatgtcggcatcaagg	14	6	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr8:103357737G>C	uc003ykr.1	-	8	806	c.773C>G	c.(772-774)TCT>TGT	p.S258C	UBR5_uc003yks.1_Missense_Mutation_p.S258C	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	258				S -> Y (in Ref. 2; AAF88143).	cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGGGTGGGCAGAATGAATGTC	0.413													0	0	0	0.080935	0	10	25										C	103357737	G	C	103357737	3	2	70	1	0	0	0	0	1	0	0	0	16902	942	33	1	7834	1	UBR5	8	103357737	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		103357737	43006285	60	21889			3	98		2	2	17	N	G_C	7.132288e-05
UBR5	51366	broad.mit.edu	37	chr8	103357753	103357753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggcagaatgaatgtcggcatCaaggagagacataagatcct	12	7	1	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr8:103357753C>G	uc003ykr.1	-	8	790	c.757G>C	c.(757-759)GAT>CAT	p.D253H	UBR5_uc003yks.1_Missense_Mutation_p.D253H	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	253					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			ATGTCGGCATCAAGGAGAGAC	0.403													0	0	0	0.028581	0	13	25										G	103357753	C	G	103357753	3	3	70	1	0	0	0	0	1	0	0	0	16902	826	29	1	7850	1	UBR5	8	103357753	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	16	103357753	43006269	61	21890			3	98		2	2	17	N	G_C	7.132288e-05
CPSF1	29894	broad.mit.edu	37	chr8	145624217	145624217	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtccacatgtcatagcagccGggaagctcaaaggttgtcac	11	11	3	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr8:145624217G>A	uc003zcj.2	-	17	1665	c.1590C>T	c.(1588-1590)CCC>CCT	p.P530P		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	530					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CATAGCAGCCGGGAAGCTCAA	0.637													0	0	0	0.038147	0	6	159										A	145624217	G	A	145624217	2	1	70	1	0	0	0	0	0	0	0	1	3824	1103	39	2		2	CPSF1	8	145624217	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	42266464	145624217	739805	62	21891										
BSPRY	54836	broad.mit.edu	37	chr9	116132396	116132396	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tcccagtctttgctgtggccGatcagaccatttctatcgtc	8	13	3	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:116132396G>C	uc004bhg.3	+	6	1231	c.1183G>C	c.(1183-1185)GAT>CAT	p.D395H	BSPRY_uc010muw.2_3'UTR	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	395	B30.2/SPRY.				calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1						TGCTGTGGCCGATCAGACCAT	0.592													0	0	0	0.104719	0	39	30										C	116132396	G	C	116132396	3	2	70	1	0	0	0	0	1	0	0	0	1532	1058	37	1	1205	1	BSPRY	9	116132396	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		116132396	25081035	63	21892										
COL27A1	85301	broad.mit.edu	37	chr9	116999271	116999271	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tctcttccaggggagccaggGgttgccagggttccccggtg	16	12	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:116999271G>A	uc011lxl.1	+	18	2630	c.2630G>A	c.(2629-2631)GGG>GAG	p.G877E	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	877	Collagen-like 5.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GGGAGCCAGGGGTTGCCAGGG	0.622													0	0	0	0.09319	0	12	10										A	116999271	G	A	116999271	3	1	70	1	0	0	0	0	1	0	0	0	3685	1232	43	2	2700	2	COL27A1	9	116999271	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	866875	116999271	24214160	64	21893										
SPTAN1	6709	broad.mit.edu	37	chr9	131370245	131370245	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgagatcaagcagaaacttGatattcttgaccaggagcgt	10	8	2	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131370245G>A	uc004bvl.3	+	33	4374	c.4261G>A	c.(4261-4263)GAT>AAT	p.D1421N	SPTAN1_uc004bvm.3_Missense_Mutation_p.D1421N|SPTAN1_uc004bvn.3_Missense_Mutation_p.D1401N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1421	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCAGAAACTTGATATTCTTGA	0.547													0	0	0	0.034045	0	29	18										A	131370245	G	A	131370245	3	1	70	1	0	0	0	0	1	0	0	0	15116	1290	45	1	4387	1	SPTAN1	9	131370245	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	14370974	131370245	9843186	65	21894			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131370275	131370275	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	accaggagcgtgcagacctgGagaaggcctgggttcagcgc	16	11	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131370275G>C	uc004bvl.3	+	33	4404	c.4291G>C	c.(4291-4293)GAG>CAG	p.E1431Q	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1431Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1411Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1431	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGCAGACCTGGAGAAGGCCTG	0.532													0	0	0	0.034045	0	30	28										C	131370275	G	C	131370275	3	2	70	1	0	0	0	0	1	0	0	0	15116	1175	41	1	4417	1	SPTAN1	9	131370275	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	30	131370275	9843156	66	21895			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131370487	131370487	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgaataccgaagacaaaggaGactcactggacagcgtagag	12	8	1	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131370487G>A	uc004bvl.3	+	34	4536	c.4423G>A	c.(4423-4425)GAC>AAC	p.D1475N	SPTAN1_uc004bvm.3_Missense_Mutation_p.D1475N|SPTAN1_uc004bvn.3_Missense_Mutation_p.D1455N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1475	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGACAAAGGAGACTCACTGGA	0.522													0	0	0	0.048971	0	82	62										A	131370487	G	A	131370487	3	1	70	1	0	0	0	0	1	0	0	0	15116	942	33	1	4553	1	SPTAN1	9	131370487	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	212	131370487	9842944	67	21896			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131371153	131371154	+	Frame_Shift_Ins	INS	-	-	A													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgcctttgttttctgacaggINSaagagaagattgctgctctg							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371153_131371154insA	uc004bvl.3	+	35	4605_4606	c.4492_4493insA	c.(4492-4494)GAAfs	p.E1498fs	SPTAN1_uc004bvm.3_Frame_Shift_Ins_p.E1498fs|SPTAN1_uc004bvn.3_Frame_Shift_Ins_p.E1478fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1498	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTTCTGACAGGAAGAGAAGATT	0.54																		50	128	---	---								A	131371154	-	A	131371153	7	5	70	1	0	1	1	0	0	0	0	0	15116	1188	41	0	4626	0	SPTAN1	9	131371153	Frame_Shift_Ins	INS	-	TCGA-E7-A3X6-01A-12D-A22Z-08	666	131371153	9842278	68	21897			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131371219	131371219	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgccggccattatgccaagGgagacatttctagccggcgc	12	13	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371219G>A	uc004bvl.3	+	35	4671	c.4558G>A	c.(4558-4560)GGA>AGA	p.G1520R	SPTAN1_uc004bvm.3_Missense_Mutation_p.G1520R|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1500R	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1520	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTATGCCAAGGGAGACATTTC	0.552													0	0	0	0.048971	0	46	92										A	131371219	G	A	131371219	3	1	70	1	0	0	0	0	1	0	0	0	15116	1233	43	2	4692	2	SPTAN1	9	131371219	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	66	131371219	9842212	69	21898			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131371243	131371243	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	acatttctagccggcgcaatGaggtcttggacaggtgggtg	15	8	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371243G>A	uc004bvl.3	+	35	4695	c.4582G>A	c.(4582-4584)GAG>AAG	p.E1528K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1528K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1508K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1528	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCGGCGCAATGAGGTCTTGGA	0.572													0	0	0	0.069456	0	37	64										A	131371243	G	A	131371243	3	1	70	1	0	0	0	0	1	0	0	0	15116	1291	45	1	4716	1	SPTAN1	9	131371243	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	24	131371243	9842188	70	21899			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131371429	131371429	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtctgaaagcccagatgattGagaaaaggtcaaagctagga	12	6	2	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371429G>A	uc004bvl.3	+	36	4737	c.4624G>A	c.(4624-4626)GAG>AAG	p.E1542K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1542K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1522K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1542	Spectrin 16.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCAGATGATTGAGAAAAGGTC	0.473													0	0	0	0.037714	0	30	37										A	131371429	G	A	131371429	3	1	70	1	0	0	0	0	1	0	0	0	15116	1291	45	1	4762	1	SPTAN1	9	131371429	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	186	131371429	9842002	71	21900			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131371495	131371495	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gccgggatgtggatgagattGaggcttggatcagtgaaaaa	16	4	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131371495G>A	uc004bvl.3	+	36	4803	c.4690G>A	c.(4690-4692)GAG>AAG	p.E1564K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1564K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1544K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1564	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGATGAGATTGAGGCTTGGAT	0.478													0	0	0	0.037714	0	28	21										A	131371495	G	A	131371495	3	1	70	1	0	0	0	0	1	0	0	0	15116	1291	45	1	4828	1	SPTAN1	9	131371495	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	66	131371495	9841936	72	21901			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131374105	131374105	+	Missense_Mutation	SNP	G	G	A													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgaacgtggagcctgtgccgGcagtgaggatgctgtcaagg							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131374105G>A	uc004bvl.3	+	37	4984	c.4871G>A	c.(4870-4872)GGC>GAC	p.G1624D	SPTAN1_uc004bvm.3_Missense_Mutation_p.G1629D|SPTAN1_uc004bvn.3_Missense_Mutation_p.G1604D	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1624	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCCTGTGCCGGCAGTGAGGAT	0.557													0	0	0	0.055883	0	14	21										A	131374105	G	A	131374105	3	1	70	1	0	0	0	0	1	0	0	0	15116	1203	42	2	5032	2	SPTAN1	9	131374105	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	2610	131374105	9839326	73	21902	113	2	4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131374110	131374110	+	Missense_Mutation	SNP	G	G	A													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtggagcctgtgccggcagtGaggatgctgtcaaggtatgg							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131374110G>A	uc004bvl.3	+	37	4989	c.4876G>A	c.(4876-4878)GAG>AAG	p.E1626K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1631K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1606K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1626	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGCCGGCAGTGAGGATGCTGT	0.557													0	0	0	0.043863	0	13	19										A	131374110	G	A	131374110	3	1	70	1	0	0	0	0	1	0	0	0	15116	1291	45	1	5037	1	SPTAN1	9	131374110	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	5	131374110	9839321	74	21903	113	2	4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131377919	131377919	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cccctgccccaggatcgcctGaaggacctgaacagccaggc	11	17	0	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131377919G>A	uc004bvl.3	+	40	5255	c.5142G>A	c.(5140-5142)CTG>CTA	p.L1714L	SPTAN1_uc004bvm.3_Silent_p.L1719L|SPTAN1_uc004bvn.3_Silent_p.L1694L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1714	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGGATCGCCTGAAGGACCTGA	0.542													0	0	0	0.038395	0	16	23										A	131377919	G	A	131377919	2	1	70	1	0	0	0	0	0	0	0	1	15116	1277	45	1		1	SPTAN1	9	131377919	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	3809	131377919	9835512	75	21904			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131378027	131378027	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gggcgcttccagaagatcaaGagcatggcggcctcccggcg	15	13	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131378027G>C	uc004bvl.3	+	40	5363	c.5250G>C	c.(5248-5250)AAG>AAC	p.K1750N	SPTAN1_uc004bvm.3_Missense_Mutation_p.K1755N|SPTAN1_uc004bvn.3_Missense_Mutation_p.K1730N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1750	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGAAGATCAAGAGCATGGCGG	0.567													0	0	0	0.069288	0	24	30										C	131378027	G	C	131378027	3	2	70	1	0	0	0	0	1	0	0	0	15116	933	33	1	5423	1	SPTAN1	9	131378027	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	108	131378027	9835404	76	21905			4	99		13	12	7794	N	G_C_-	2.143273e-24
SPTAN1	6709	broad.mit.edu	37	chr9	131378038	131378038	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gaagatcaagagcatggcggCctcccggcgagccaagctga	14	12	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr9:131378038C>T	uc004bvl.3	+	40	5374	c.5261C>T	c.(5260-5262)GCC>GTC	p.A1754V	SPTAN1_uc004bvm.3_Missense_Mutation_p.A1759V|SPTAN1_uc004bvn.3_Missense_Mutation_p.A1734V	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1754	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGCATGGCGGCCTCCCGGCGA	0.572													0	0	0	0.049695	0	21	27										T	131378038	C	T	131378038	3	4	70	1	0	0	0	0	1	0	0	0	15116	739	26	2	5434	2	SPTAN1	9	131378038	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	11	131378038	9835393	77	21906			4	99		13	12	7794	N	G_C_-	2.143273e-24
WAC	51322	broad.mit.edu	37	chr10	28903604	28903604	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgtctctcctcgaagtcttCagcgctcaaggtaggttgat	10	11	4	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr10:28903604C>T	uc001iuf.2	+	11	1631	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	WAC_uc001iud.2_Nonsense_Mutation_p.Q471*|WAC_uc001iue.2_Nonsense_Mutation_p.Q206*|WAC_uc001iug.2_Nonsense_Mutation_p.Q413*|WAC_uc001iuh.2_Nonsense_Mutation_p.Q468*	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	516					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						TCGAAGTCTTCAGCGCTCAAG	0.408													0	0	0	0.034045	0	26	53										T	28903604	C	T	28903604	4	4	70	1	0	0	0	0	0	1	0	0	17244	827	29	1	1588	1	WAC	10	28903604	Nonsense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		28903604	106631143	78	21907										
HPS6	79803	broad.mit.edu	37	chr10	103825676	103825676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aggagcggcaggcccgggccGagggcccgtcagggtcgcca	19	14	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr10:103825676G>A	uc001kuj.2	+	1	530	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_024747	NP_079023	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome-6	149						cytosol|early endosome membrane|endoplasmic reticulum|microsome					0		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		GGCCCGGGCCGAGGGCCCGTC	0.736									Hermansky-Pudlak_syndrome				0	0	0	0.009096	0	4	0										A	103825676	G	A	103825676	3	1	70	1	0	0	0	0	1	0	0	0	7343	1059	37	1	447	1	HPS6	10	103825676	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	74922072	103825676	31709071	79	21908										
OR51D1	390038	broad.mit.edu	37	chr11	4661394	4661394	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgctctgtcagccgtggagtCagctgtcctgctggccatgg	14	12	3	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:4661394C>T	uc010qyk.1	+	1	374	c.374C>T	c.(373-375)TCA>TTA	p.S125L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	125	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCGTGGAGTCAGCTGTCCTG	0.547													0	0	0	0.064281	0	37	25										T	4661394	C	T	4661394	3	4	70	1	0	0	0	0	1	0	0	0	11093	838	29	1	376	1	OR51D1	11	4661394	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		4661394	130345122	80	21909										
OR51D1	390038	broad.mit.edu	37	chr11	4661499	4661499	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgtggccaagattggactatCtgccctgaccagggggtttg	14	9	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:4661499C>T	uc010qyk.1	+	1	479	c.479C>T	c.(478-480)TCT>TTT	p.S160F		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTGGACTATCTGCCCTGACC	0.532													0	0	0	0.048971	0	60	64										T	4661499	C	T	4661499	3	4	70	1	0	0	0	0	1	0	0	0	11093	913	32	1	481	1	OR51D1	11	4661499	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	105	4661499	130345017	81	21910										
CAPRIN1	4076	broad.mit.edu	37	chr11	34097866	34097867	+	Missense_Mutation	DNP	TG	TG	CA													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aaacgtttaaaaactgtactTgagctacagtatgttttgga					rs140627436	byFrequency	TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:34097866_34097867TG>CA	uc001mvh.1	+	5	639_640	c.450_451TG>CA	c.(448-453)CTTGAG>CTCAAG	p.E151K	CAPRIN1_uc001mvg.2_Missense_Mutation_p.E151K|CAPRIN1_uc001mvi.2_Missense_Mutation_p.E151K|CAPRIN1_uc001mvj.1_Missense_Mutation_p.E70K	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	151	Potential.				negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				AAACTGTACTTGAGCTACAGTA	0.401													0	0	0	0.004672	0	26	24										CA	34097867	TG	CA	34097866	3	2	70	1	0	0	0	0	1	0	0	0	2635	1799	63	5	464	5	CAPRIN1	11	34097866	Missense_Mutation	DNP	TG	TCGA-E7-A3X6-01A-12D-A22Z-08	29436367	34097866	100908650	82	21911										
PCNXL3	399909	broad.mit.edu	37	chr11	65385501	65385501	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gccttctcccctggctggagAtggagcgccctggagtggga	16	12	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:65385501A>G	uc001oey.2	+	6	668	c.668A>G	c.(667-669)GAT>GGT	p.D223G		NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	223						integral to membrane					0						CTGGCTGGAGATGGAGCGCCC	0.622													0	0	0	0.02938	0	7	8										G	65385501	A	G	65385501	3	3	70	1	0	0	0	0	1	0	0	0	11593	333	12	5	690	5	PCNXL3	11	65385501	Missense_Mutation	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	31287635	65385501	69621015	83	21912										
SHANK2	22941	broad.mit.edu	37	chr11	70332827	70332827	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gccggctgtgccgctgctcgCggagggcactgctgggctgc	18	14	0	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:70332827C>T	uc001oqc.2	-	21	3649	c.3571G>A	c.(3571-3573)GCG>ACG	p.A1191T	SHANK2_uc010rqn.1_Missense_Mutation_p.A603T|SHANK2_uc001opz.2_Missense_Mutation_p.A596T|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	812					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCGCTGCTCGCGGAGGGCACT	0.706													0	0	0	0.020292	0	15	48										T	70332827	C	T	70332827	3	4	70	1	0	0	0	0	1	0	0	0	14265	768	27	2	1986	2	SHANK2	11	70332827	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	4947326	70332827	64673689	84	21913										
ARHGEF12	23365	broad.mit.edu	37	chr11	120298916	120298916	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tcctcattcacctggagcatCtgggaatatggagagaatca	10	9	4	1	rs147982337	by1000genomes	TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:120298916C>G	uc001pxl.1	+	8	552	c.545C>G	c.(544-546)TCT>TGT	p.S182C	ARHGEF12_uc009zat.2_Missense_Mutation_p.S163C|ARHGEF12_uc010rzn.1_Missense_Mutation_p.S79C|ARHGEF12_uc009zau.1_Missense_Mutation_p.S79C	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	182					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CCTGGAGCATCTGGGAATATG	0.458			T	MLL	AML								0	0	0	0.048971	0	73	117										G	120298916	C	G	120298916	3	3	70	1	0	0	0	0	1	0	0	0	897	913	32	1	575	1	ARHGEF12	11	120298916	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	49966089	120298916	14707600	85	21914										
IGSF9B	22997	broad.mit.edu	37	chr11	133789947	133789947	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgctgcaggaggcccgggcGaggccgggcacgggcggcga	21	13	0	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr11:133789947G>C	uc001qgx.3	-	18	3904	c.3673C>G	c.(3673-3675)CGC>GGC	p.R1225G		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1225	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGGCCCGGGCGAGGCCGGGCA	0.677													0	0	0	0.049695	0	21	45										C	133789947	G	C	133789947	3	2	70	1	0	0	0	0	1	0	0	0	7606	1058	37	1	384	1	IGSF9B	11	133789947	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	13491031	133789947	1216569	86	21915										
CAPRIN2	65981	broad.mit.edu	37	chr12	30863384	30863384	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tctttctgggctgctcacctGagaagaatcactccaccctg	8	14	4	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr12:30863384G>A	uc001rji.1	-	18	3587	c.2836C>T	c.(2836-2838)CAG>TAG	p.Q946*	CAPRIN2_uc001rjf.1_Silent_p.L756L|CAPRIN2_uc001rjg.1_Nonsense_Mutation_p.Q613*|CAPRIN2_uc001rjh.1_Nonsense_Mutation_p.Q896*|CAPRIN2_uc001rjj.1_Nonsense_Mutation_p.Q612*|CAPRIN2_uc001rjk.3_Silent_p.L959L|CAPRIN2_uc001rjl.3_Silent_p.L904L	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	946					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CTGCTCACCTGAGAAGAATCA	0.448													0	0	0	0.048971	0	88	153										A	30863384	G	A	30863384	4	1	70	1	0	0	0	0	0	1	0	0	2636	1299	45	1	551	1	CAPRIN2	12	30863384	Nonsense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		30863384	102988511	87	21916										
SELPLG	6404	broad.mit.edu	37	chr12	109017670	109017670	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggagtggtctgtgcctccgtGggcactggttgagtggtctg	18	8	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr12:109017670G>T	uc001tni.2	-	2	574	c.414C>A	c.(412-414)CCC>CCA	p.P138P	SELPLG_uc001tnh.2_Intron|SELPLG_uc010sxe.1_Silent_p.P154P	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	138	2.|Extracellular (Potential).|12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						GTGCCTCCGTGGGCACTGGTT	0.612													1	0	7.26314e-15	0.034045	7.70602e-15	29	71										T	109017670	G	T	109017670	2	4	70	1	0	0	0	0	0	0	0	1	14020	1363	47	4		4	SELPLG	12	109017670	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	78154286	109017670	24834225	88	21917										
CORO1C	23603	broad.mit.edu	37	chr12	109095087	109095087	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	acttgctctgtcgtaccactCgcctcatcgtgtctgcaaag	8	14	3	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr12:109095087C>G	uc001tnj.2	-	2	104	c.8G>C	c.(7-9)CGA>CCA	p.R3P	CORO1C_uc009zva.2_Missense_Mutation_p.R56P|CORO1C_uc010sxf.1_Missense_Mutation_p.R3P	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	3					actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						TCGTACCACTCGCCTCATCGT	0.428													0	0	0	0.080422	0	39	72										G	109095087	C	G	109095087	3	3	70	1	0	0	0	0	1	0	0	0	3755	884	31	1	1456	1	CORO1C	12	109095087	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	77417	109095087	24756808	89	21918										
NUDT15	55270	broad.mit.edu	37	chr13	48611984	48611984	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgcgtcctcctggggaagagGaaaggctcggttggagctgg	18	8	0	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:48611984G>C	uc001vbw.1	+	1	282	c.102G>C	c.(100-102)AGG>AGC	p.R34S	SUCLA2_uc010tgd.1_5'UTR|NUDT15_uc001vbv.2_Missense_Mutation_p.R34S	NM_018283	NP_060753	Q9NV35	NUD15_HUMAN	nudix-type motif 15	34	Nudix hydrolase.						hydrolase activity|metal ion binding				0		all_cancers(8;3.75e-25)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|all_hematologic(8;0.000219)|Lung NSC(96;0.000226)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;4.83e-07)		TGGGGAAGAGGAAAGGCTCGG	0.682											OREG0022405	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	4										C	48611984	G	C	48611984	3	2	70	1	0	0	0	0	1	0	0	0	10731	1165	41	1	104	1	NUDT15	13	48611984	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		48611984	66557894	90	21919										
RBM26	64062	broad.mit.edu	37	chr13	79928636	79928636	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aatagtacttgaaggtactgGacccagccgctctttgactg	10	10	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:79928636G>C	uc001vkz.2	-	13	1944	c.1930C>G	c.(1930-1932)CCA>GCA	p.P644A	RBM26_uc001vky.2_Missense_Mutation_p.P639A|RBM26_uc001vla.2_Missense_Mutation_p.P642A|RBM26_uc010tia.1_Missense_Mutation_p.P23A|RBM26_uc001vkx.2_Missense_Mutation_p.P354A	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	642					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GAAGGTACTGGACCCAGCCGC	0.463													0	0	0	0.014758	0	4	77										C	79928636	G	C	79928636	3	2	70	1	0	0	0	0	1	0	0	0	13126	1174	41	1	1063	1	RBM26	13	79928636	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	31316652	79928636	35241242	91	21920										
FARP1	10160	broad.mit.edu	37	chr13	99083532	99083532	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cgccgacttcagggactgccGaggtgagtgctgggagcctg	17	11	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:99083532G>A	uc001vnj.2	+	18	2477	c.2141G>A	c.(2140-2142)CGA>CAA	p.R714Q	FARP1_uc001vnh.2_Missense_Mutation_p.R714Q	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	714	DH.		R -> L (in a breast cancer sample; somatic mutation).		regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity	p.R714L(2)		breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGGGACTGCCGAGGTGAGTGC	0.687													0	0	0	0.021553	0	4	3										A	99083532	G	A	99083532	3	1	70	1	0	0	0	0	1	0	0	0	5676	1058	37	1	2430	1	FARP1	13	99083532	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	19154896	99083532	16086346	92	21921										
TM9SF2	9375	broad.mit.edu	37	chr13	100154005	100154005	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cgcccgtcaacttctgcgacGaagaaaaaaagagcgacgag	11	11	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr13:100154005G>A	uc001voj.1	+	1	278	c.145G>A	c.(145-147)GAA>AAA	p.E49K	TM9SF2_uc010afz.1_Missense_Mutation_p.E49K	NM_004800	NP_004791	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2 precursor	49	Lumenal (Potential).				transport	endosome membrane|integral to plasma membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CTTCTGCGACGAAGAAAAAAA	0.647													0	0	0	0.045705	0	30	34										A	100154005	G	A	100154005	3	1	70	1	0	0	0	0	1	0	0	0	15975	1059	37	1	147	1	TM9SF2	13	100154005	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	1070473	100154005	15015873	93	21922										
TMEM55B	90809	broad.mit.edu	37	chr14	20928871	20928871	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgatgcatcttgccttccacGttgatgagagattggcagac	11	9	1	5	rs150985847		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:20928871G>A	uc001vxl.2	-	2	429	c.276C>T	c.(274-276)AAC>AAT	p.N92N	TMEM55B_uc001vxk.2_Silent_p.N99N	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	92						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		TGCCTTCCACGTTGATGAGAG	0.527													0	0	0	0.050027	0	32	84										A	20928871	G	A	20928871	2	1	70	1	0	0	0	0	0	0	0	1	16179	1136	40	2		2	TMEM55B	14	20928871	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		20928871	86420669	94	21923										
SOS2	6655	broad.mit.edu	37	chr14	50626242	50626242	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tctactttgcaagttgtcttCaaaaacaatgttttcctcag	5	9	4	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:50626242C>G	uc001wxs.3	-	10	1857	c.1759G>C	c.(1759-1761)GAA>CAA	p.E587Q	SOS2_uc010tql.1_Missense_Mutation_p.E554Q|SOS2_uc010tqm.1_RNA|SOS2_uc001wxt.2_Missense_Mutation_p.E275Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	587					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					AAGTTGTCTTCAAAAACAATG	0.338													0	0	0	0.039052	0	44	85										G	50626242	C	G	50626242	3	3	70	1	0	0	0	0	1	0	0	0	14937	835	29	1	2295	1	SOS2	14	50626242	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	29697371	50626242	56723298	95	21924										
FBXO34	55030	broad.mit.edu	37	chr14	55817155	55817155	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccagaagaaagagcacccccCggaagtcagcagggaaacgc	12	13	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:55817155C>T	uc001xbu.2	+	2	292	c.47C>T	c.(46-48)CCG>CTG	p.P16L	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Missense_Mutation_p.P16L	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	16										ovary(2)|lung(2)|skin(1)	5						GAGCACCCCCCGGAAGTCAGC	0.423													0	0	0	0.020292	0	15	45										T	55817155	C	T	55817155	3	4	70	1	0	0	0	0	1	0	0	0	5744	652	23	2	49	2	FBXO34	14	55817155	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	5190913	55817155	51532385	96	21925										
PSEN1	5663	broad.mit.edu	37	chr14	73683862	73683862	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aaacttggattgggagatttCattttctacagtgttctggt	10	5	3	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:73683862C>A	uc001xnr.2	+	11	1442	c.1158C>A	c.(1156-1158)TTC>TTA	p.F386L	PSEN1_uc001xnv.2_Missense_Mutation_p.F382L|PSEN1_uc010ark.2_Missense_Mutation_p.F382L|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	386	Required for interaction with CTNND2.|Required for interaction with CTNNB1.|Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		TGGGAGATTTCATTTTCTACA	0.368													1	0	5.85753e-14	0.048971	6.17703e-14	51	74										A	73683862	C	A	73683862	3	1	70	1	0	0	0	0	1	0	0	0	12650	825	29	3	1192	3	PSEN1	14	73683862	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	17866707	73683862	33665678	97	21926										
AHNAK2	113146	broad.mit.edu	37	chr14	105411641	105411641	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccctttgaggccagctccctCgggcacgtggccctccggga	13	17	0	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr14:105411641C>T	uc010axc.1	-	7	10267	c.10147G>A	c.(10147-10149)GAG>AAG	p.E3383K	AHNAK2_uc001ypx.2_Missense_Mutation_p.E3283K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3383						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCAGCTCCCTCGGGCACGTGG	0.632													0	0	0	0.048971	0	94	225										T	105411641	C	T	105411641	3	4	70	1	0	0	0	0	1	0	0	0	415	893	31	1	7244	1	AHNAK2	14	105411641	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	31727779	105411641	1937899	98	21927										
C15orf52	388115	broad.mit.edu	37	chr15	40630039	40630040	+	Frame_Shift_Ins	INS	-	-	C													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgcttccactgggcatagtINScccagcccgcctccgggggc							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:40630039_40630040insC	uc001zlh.3	-	6	716_717	c.700_701insG	c.(700-702)GACfs	p.D234fs	C15orf52_uc001zli.1_Frame_Shift_Ins_p.D166fs|C15orf52_uc010ucn.1_Frame_Shift_Ins_p.D24fs	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	234										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTGGGCATAGTCCCAGCCCGCC	0.693																		9	32	---	---								C	40630040	-	C	40630039	7	5	70	1	0	1	1	0	0	0	0	0	1800	1667	58	0	927	0	C15orf52	15	40630039	Frame_Shift_Ins	INS	-	TCGA-E7-A3X6-01A-12D-A22Z-08		40630039	61901353	99	21928										
TPM1	7168	broad.mit.edu	37	chr15	63354444	63354444	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aggaagacagatatgaggaaGagatcaaggtcctttccgac	12	7	1	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:63354444G>C	uc002alg.2	+	7	861	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	TPM1_uc002alh.2_Missense_Mutation_p.E224Q|TPM1_uc010bgn.2_RNA|TPM1_uc002ali.2_Missense_Mutation_p.E224Q|TPM1_uc002alj.2_Missense_Mutation_p.E224Q|TPM1_uc002alk.2_Missense_Mutation_p.E224Q|TPM1_uc002all.2_Missense_Mutation_p.E224Q|TPM1_uc002alm.2_Missense_Mutation_p.E266Q|TPM1_uc010uie.1_Missense_Mutation_p.E224Q|TPM1_uc002alp.2_Missense_Mutation_p.E224Q|TPM1_uc010uif.1_Missense_Mutation_p.E188Q|TPM1_uc002alr.2_Missense_Mutation_p.E188Q|TPM1_uc002als.2_Missense_Mutation_p.E188Q|TPM1_uc010uig.1_Missense_Mutation_p.E188Q|TPM1_uc002alt.2_Missense_Mutation_p.E188Q|TPM1_uc010bgp.2_Missense_Mutation_p.E98Q	NM_001018005	NP_001018005	P09493	TPM1_HUMAN	tropomyosin 1 alpha chain isoform 1	224	By similarity.				cardiac muscle contraction|cellular component movement|cellular response to reactive oxygen species|muscle filament sliding|negative regulation of cell migration|positive regulation of ATPase activity|positive regulation of cell adhesion|positive regulation of heart rate by epinephrine|positive regulation of stress fiber assembly|regulation of muscle contraction|ruffle organization|sarcomere organization|ventricular cardiac muscle tissue morphogenesis|wound healing	bleb|cytosol|muscle thin filament tropomyosin|ruffle membrane|stress fiber	actin binding|structural constituent of cytoskeleton|structural constituent of muscle				0						ATATGAGGAAGAGATCAAGGT	0.433													0	0	0	0.041601	0	28	69										C	63354444	G	C	63354444	3	2	70	1	0	0	0	0	1	0	0	0	16402	943	33	1	1042	1	TPM1	15	63354444	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	22724405	63354444	39176948	100	21929										
RPL4	6124	broad.mit.edu	37	chr15	66794183	66794183	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	agcaaaacagcttccttggtCttcttgtagccttcaacttt	6	11	3	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:66794183C>G	uc002apv.2	-	5	545	c.489G>C	c.(487-489)AAG>AAC	p.K163N	RPL4_uc010bhr.2_Missense_Mutation_p.K69N|RPL4_uc002apw.2_Missense_Mutation_p.K69N|RPL4_uc002apx.2_Missense_Mutation_p.K69N|RPL4_uc010ujq.1_Missense_Mutation_p.K163N|SNORD18C_uc010bhs.1_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	163					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						CTTCCTTGGTCTTCTTGTAGC	0.383													0	0	0	0.041601	0	31	49										G	66794183	C	G	66794183	3	3	70	1	0	0	0	0	1	0	0	0	13595	912	32	1	818	1	RPL4	15	66794183	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	3439739	66794183	35737209	101	21930										
SEMA4B	10509	broad.mit.edu	37	chr15	90771602	90771602	+	Frame_Shift_Del	DEL	C	C	-													0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cggaacagcatgaaagtcttCctgaagcagggggaatgtgc							TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr15:90771602delC	uc002boy.2	+	15	2524	c.2241delC	c.(2239-2241)TTCfs	p.F747fs	SEMA4B_uc002boz.2_Frame_Shift_Del_p.F747fs|SEMA4B_uc010uqd.1_Frame_Shift_Del_p.F585fs|SEMA4B_uc002bpa.2_Frame_Shift_Del_p.F585fs|SEMA4B_uc010bnv.1_Intron	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			TGAAAGTCTTCCTGAAGCAGG	0.612																		16	26	---	---								-	90771602	C	-	90771602	7	5	70	1	0	1	0	1	0	0	0	0	14032	854	30	0	2295	0	SEMA4B	15	90771602	Frame_Shift_Del	DEL	C	TCGA-E7-A3X6-01A-12D-A22Z-08	23977419	90771602	11759790	102	21931										
TPSG1	25823	broad.mit.edu	37	chr16	1271924	1271924	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gggggagcctggggtacccaGactctgagccccctgatgct	15	13	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:1271924G>C	uc002ckw.2	-	6	832	c.830C>G	c.(829-831)TCT>TGT	p.S277C		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	277					proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GGGGTACCCAGACTCTGAGCC	0.657													0	0	0	0.069234	0	10	22										C	1271924	G	C	1271924	3	2	70	1	0	0	0	0	1	0	0	0	16423	942	33	1	139	1	TPSG1	16	1271924	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		1271924	89082829	103	21932										
TPSG1	25823	broad.mit.edu	37	chr16	1271985	1271985	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gttcacgtaggcagggacacGagtgtagactcccggcctgt	14	11	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:1271985G>A	uc002ckw.2	-	6	771	c.769C>T	c.(769-771)CGT>TGT	p.R257C		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	257	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GCAGGGACACGAGTGTAGACT	0.672													0	0	0	0.080935	0	11	28										A	1271985	G	A	1271985	3	1	70	1	0	0	0	0	1	0	0	0	16423	1058	37	1	200	1	TPSG1	16	1271985	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	61	1271985	89082768	104	21933										
ITGAL	3683	broad.mit.edu	37	chr16	30521724	30521724	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gctgcgaggagcttcctgaaGagtccaggcttctgtccagg	14	11	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:30521724G>A	uc002dyi.3	+	22	2727	c.2551G>A	c.(2551-2553)GAG>AAG	p.E851K	ITGAL_uc002dyj.3_Missense_Mutation_p.E767K|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	851	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GCTTCCTGAAGAGTCCAGGCT	0.532													0	0	0	0.039052	0	41	88										A	30521724	G	A	30521724	3	1	70	1	0	0	0	0	1	0	0	0	7886	943	33	1	2637	1	ITGAL	16	30521724	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	29249739	30521724	59833029	105	21934										
IRX6	79190	broad.mit.edu	37	chr16	55362791	55362791	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggccgtgcgctgcagctcgaGagggccgattggagcgcagg	19	11	0	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:55362791G>C	uc002ehy.2	+	5	1434	c.901G>C	c.(901-903)GAG>CAG	p.E301Q	IRX6_uc002ehx.2_Missense_Mutation_p.E301Q	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	301						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						TGCAGCTCGAGAGGGCCGATT	0.597													0	0	0	0.069288	0	23	56										C	55362791	G	C	55362791	3	2	70	1	0	0	0	0	1	0	0	0	7848	943	33	1	919	1	IRX6	16	55362791	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	24841067	55362791	34991962	106	21935										
CDH3	1001	broad.mit.edu	37	chr16	68716273	68716273	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgacggtcactgatctggaCgcccccaactcaccagcgtg	10	16	3	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:68716273C>T	uc002ewf.2	+	9	2197	c.1065C>T	c.(1063-1065)GAC>GAT	p.D355D	CDH3_uc010vli.1_Silent_p.D300D	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	355	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CTGATCTGGACGCCCCCAACT	0.592													0	0	0	0.038395	0	17	28										T	68716273	C	T	68716273	2	4	70	1	0	0	0	0	0	0	0	1	3111	535	19	2		2	CDH3	16	68716273	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	13353482	68716273	21638480	107	21936										
CYB5B	80777	broad.mit.edu	37	chr16	69458658	69458658	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	caggaagtcgagacctcagtCacctattaccggttggagga	12	10	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:69458658C>T	uc002exg.1	+	1	161	c.72C>T	c.(70-72)GTC>GTT	p.V24V	CYB5B_uc002exf.2_Silent_p.V24V|CYB5B_uc010cfl.1_Silent_p.V24V	NM_030579	NP_085056	O43169	CYB5B_HUMAN	cytochrome b5 outer mitochondrial membrane	20	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding				0		Ovarian(137;0.101)				AGACCTCAGTCACCTATTACC	0.567													0	0	0	0.034045	0	28	52										T	69458658	C	T	69458658	2	4	70	1	0	0	0	0	0	0	0	1	4123	813	29	1		1	CYB5B	16	69458658	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	742385	69458658	20896095	108	21937										
TCF25	22980	broad.mit.edu	37	chr16	89967083	89967083	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gctccctaattttgccttctCtgttccactggcgtatttcc	6	14	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr16:89967083C>G	uc002fpb.2	+	12	1344	c.1262C>G	c.(1261-1263)TCT>TGT	p.S421C	TCF25_uc002fpc.2_Missense_Mutation_p.S186C	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	421					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TTTGCCTTCTCTGTTCCACTG	0.532													0	0	0	0.045705	0	31	53										G	89967083	C	G	89967083	3	3	70	1	0	0	0	0	1	0	0	0	15690	913	32	1	1308	1	TCF25	16	89967083	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	20508425	89967083	387670	109	21938										
DNAH2	146754	broad.mit.edu	37	chr17	7697658	7697658	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cggagtcgcttcaacattatCaacatgaccttccccacagt	6	14	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:7697658C>G	uc002giu.1	+	48	7670	c.7656C>G	c.(7654-7656)ATC>ATG	p.I2552M		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2552	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCAACATTATCAACATGACCT	0.592													0	0	0	0.041601	0	29	42										G	7697658	C	G	7697658	3	3	70	1	0	0	0	0	1	0	0	0	4602	816	29	1	7846	1	DNAH2	17	7697658	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		7697658	73497552	110	21939										
CNTROB	116840	broad.mit.edu	37	chr17	7843441	7843441	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gccagagggaagcccaggccGcctgggagacccagcaccag	15	15	0	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:7843441G>T	uc002gjq.2	+	10	2111	c.1192G>T	c.(1192-1194)GCC>TCC	p.A398S	CNTROB_uc002gjp.2_Missense_Mutation_p.A398S|CNTROB_uc002gjr.2_Missense_Mutation_p.A300S|CNTROB_uc010vum.1_Missense_Mutation_p.A110S	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	398	Potential.|Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				AGCCCAGGCCGCCTGGGAGAC	0.532													1	0	1.06801e-11	0.041601	1.11278e-11	31	80										T	7843441	G	T	7843441	3	4	70	1	0	0	0	0	1	0	0	0	3651	1087	38	4	1226	4	CNTROB	17	7843441	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	145783	7843441	73351769	111	21940										
PHOSPHO1	162466	broad.mit.edu	37	chr17	47302012	47302012	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gctgtggtggccggcggcgcGcagcgagctctccacgccaa	16	15	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:47302012G>A	uc010wlv.1	-	3	766	c.400C>T	c.(400-402)CGC>TGC	p.R134C	PHOSPHO1_uc002ios.2_Missense_Mutation_p.R159C	NM_178500	NP_848595	Q8TCT1	PHOP1_HUMAN	phosphatase, orphan 1 isoform 2	134					regulation of bone mineralization		metal ion binding|phosphoethanolamine/phosphocholine phosphatase activity				0			Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)		Choline(DB00122)	CCGGCGGCGCGCAGCGAGCTC	0.657													0	0	0	0.004672	0	3	6										A	47302012	G	A	47302012	3	1	70	1	0	0	0	0	1	0	0	0	11856	1087	38	2	407	2	PHOSPHO1	17	47302012	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	39458571	47302012	33893198	112	21941										
KIF2B	84643	broad.mit.edu	37	chr17	51901070	51901070	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggaagcggcctctcaaccagCgagagacaaccttaaaggac	11	12	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:51901070C>T	uc002iua.2	+	1	832	c.676C>T	c.(676-678)CGA>TGA	p.R226*	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	226	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TCTCAACCAGCGAGAGACAAC	0.557													0	0	0	0.049695	0	20	33										T	51901070	C	T	51901070	4	4	70	1	0	0	0	0	0	1	0	0	8298	760	27	2	678	2	KIF2B	17	51901070	Nonsense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	4599058	51901070	29294140	113	21942										
ABCA9	10350	broad.mit.edu	37	chr17	66972297	66972297	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgctccagggtagactgtgaGaggctgtactcctccaggtc	13	11	0	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:66972297G>T	uc002jhu.2	-	38	4898	c.4755C>A	c.(4753-4755)CTC>CTA	p.L1585L	ABCA9_uc010dez.2_Silent_p.L1547L	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1585					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TAGACTGTGAGAGGCTGTACT	0.403													1	0	3.8784e-16	0.062417	4.14014e-16	21	63										T	66972297	G	T	66972297	2	4	70	1	0	0	0	0	0	0	0	1	39	929	33	3		3	ABCA9	17	66972297	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	15071227	66972297	14222913	114	21943										
ACTG1	71	broad.mit.edu	37	chr17	79477994	79477994	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cgccagggcggtgatctcctTctgcatcctgtcggcaatgc	12	14	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:79477994T>C	uc002kaj.1	-	4	968	c.943A>G	c.(943-945)AAG>GAG	p.K315E	ACTG1_uc002kah.1_Missense_Mutation_p.K193E|ACTG1_uc002kai.1_Missense_Mutation_p.K272E|ACTG1_uc002kak.1_Missense_Mutation_p.K315E|ACTG1_uc010wun.1_Missense_Mutation_p.K315E|ACTG1_uc002kal.1_Missense_Mutation_p.K315E|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	315					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			GTGATCTCCTTCTGCATCCTG	0.632													0	0	0	0.064281	0	36	66										C	79477994	T	C	79477994	3	2	70	1	0	0	0	0	1	0	0	0	196	1792	62	5	192	5	ACTG1	17	79477994	Missense_Mutation	SNP	T	TCGA-E7-A3X6-01A-12D-A22Z-08	12505697	79477994	1717216	115	21944										
NPLOC4	55666	broad.mit.edu	37	chr17	79534448	79534448	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cacttggacacgcacctgcaGaggcataacttcattggtga	10	11	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr17:79534448G>C	uc002kat.3	-	15	1743	c.1561C>G	c.(1561-1563)CTG>GTG	p.L521V	NPLOC4_uc002kau.3_Missense_Mutation_p.L521V|NPLOC4_uc010wur.1_Missense_Mutation_p.L360V|NPLOC4_uc010dic.2_5'Flank|NPLOC4_uc002kas.2_Silent_p.L44L	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	521					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CGCACCTGCAGAGGCATAACT	0.502													0	0	0	0.038147	0	8	11										C	79534448	G	C	79534448	3	2	70	1	0	0	0	0	1	0	0	0	10586	933	33	1	277	1	NPLOC4	17	79534448	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	56454	79534448	1660762	116	21945										
C18orf34	374864	broad.mit.edu	37	chr18	30554631	30554631	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cacagtgtgtgcatccttctCtgcagctgacagagctaaag	10	11	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr18:30554631C>G	uc002kxn.2	-	21	2545	c.2403G>C	c.(2401-2403)CAG>CAC	p.Q801H	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Missense_Mutation_p.Q265H|C18orf34_uc010xbr.1_Missense_Mutation_p.Q825H|C18orf34_uc010dmf.1_Missense_Mutation_p.Q121H|C18orf34_uc002kxo.2_Missense_Mutation_p.Q763H|C18orf34_uc002kxp.2_Missense_Mutation_p.Q801H	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	801										ovary(1)	1						GCATCCTTCTCTGCAGCTGAC	0.502													0	0	0	0.024245	0	16	16										G	30554631	C	G	30554631	3	3	70	1	0	0	0	0	1	0	0	0	1902	912	32	1	208	1	C18orf34	18	30554631	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08		30554631	47522617	117	21946										
KIAA1632	57724	broad.mit.edu	37	chr18	43534669	43534669	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tcactgcgaagcaagggtttCactgccaccaaagctggtgc	11	12	2	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr18:43534669C>G	uc002lbm.2	-	2	799	c.699G>C	c.(697-699)GTG>GTC	p.V233V	KIAA1632_uc002lbo.1_Silent_p.V233V	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	233					autophagy						0						GCAAGGGTTTCACTGCCACCA	0.483													0	0	0	0.09836	0	41	30										G	43534669	C	G	43534669	2	3	70	1	0	0	0	0	0	0	0	1	8249	813	29	1		1	KIAA1632	18	43534669	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	12980038	43534669	34542579	118	21947										
KIAA1632	57724	broad.mit.edu	37	chr18	43535299	43535299	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgaggagtttcatacttcttCttttcctaaaaacaacatac	4	9	3	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr18:43535299C>G	uc002lbm.2	-	2	169	c.69G>C	c.(67-69)AAG>AAC	p.K23N	KIAA1632_uc002lbo.1_Missense_Mutation_p.K23N	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	23					autophagy						0						CATACTTCTTCTTTTCCTAAA	0.353													0	0	0	0.080935	0	12	12										G	43535299	C	G	43535299	3	3	70	1	0	0	0	0	1	0	0	0	8249	912	32	1	7842	1	KIAA1632	18	43535299	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	630	43535299	34541949	119	21948										
DAPK3	1613	broad.mit.edu	37	chr19	3959237	3959237	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	aggcggctgaagcggcgcttGaggccgctggtccccagcag	17	13	0	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:3959237G>A	uc002lzc.1	-	8	1320	c.1227C>T	c.(1225-1227)CTC>CTT	p.L409L	DAPK3_uc002lzb.1_Silent_p.L146L|DAPK3_uc002lzd.1_Silent_p.L409L	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	409	Interaction with CDC5L (By similarity).				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGGCGCTTGAGGCCGCTGG	0.701													0	0	0	0.047766	0	8	9										A	3959237	G	A	3959237	2	1	70	1	0	0	0	0	0	0	0	1	4237	1277	45	1		1	DAPK3	19	3959237	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		3959237	55169746	120	21949										
ADAMTS10	81794	broad.mit.edu	37	chr19	8661877	8661877	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tcctgtcccctcaccgtgtgAtgagcactgctgtgtcatgg	11	13	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:8661877A>G	uc002mkj.1	-	8	1308	c.1034T>C	c.(1033-1035)ATC>ACC	p.I345T	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	345	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCACCGTGTGATGAGCACTGC	0.537													0	0	0	0.108266	0	27	62										G	8661877	A	G	8661877	3	3	70	1	0	0	0	0	1	0	0	0	256	333	12	5	2353	5	ADAMTS10	19	8661877	Missense_Mutation	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	4702640	8661877	50467106	121	21950										
C19orf56	51398	broad.mit.edu	37	chr19	12780451	12780451	+	Translation_Start_Site	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ggcttcaatagttccaacccGatcaccgaaatgccaaaatg	7	12	2	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:12780451G>C	uc002mud.2	-	1	15	c.-233C>G	c.(-235--231)ATCGG>ATGGG		MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_Intron|WDR83_uc002muc.2_Intron|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398							integral to membrane					0						GTTCCAACCCGATCACCGAAA	0.458													0	0	0	0.004672	0	3	4										C	12780451	G	C	12780451	1	2	70	1	0	0	0	0	0	0	0	0	1938	1073	37	1		1	C19orf56	19	12780451	Translation_Start_Site	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	4118574	12780451	46348532	122	21951										
WDR83	84292	broad.mit.edu	37	chr19	12780828	12780828	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctgacgtgcggcagtgacaaGacgctgaagctgtggaaccc	14	11	0	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:12780828G>A	uc002mue.3	+	4	476	c.141G>A	c.(139-141)AAG>AAA	p.K47K	WDR83_uc002muc.2_RNA|C19orf56_uc002mud.2_5'Flank|WDR83_uc010dyw.2_Silent_p.K47K	NM_001099737	NP_001093207	Q9BRX9	WDR83_HUMAN	mitogen-activated protein kinase organizer 1	47	WD 1.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2						GCAGTGACAAGACGCTGAAGC	0.677													0	0	0	0.074837	0	40	96										A	12780828	G	A	12780828	2	1	70	1	0	0	0	0	0	0	0	1	17329	933	33	1		1	WDR83	19	12780828	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	377	12780828	46348155	123	21952										
NACC1	112939	broad.mit.edu	37	chr19	13246039	13246039	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gccatggcccagacactgcaGatggagatcccgaacttcgg	12	13	0	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:13246039G>C	uc002mwm.2	+	2	186	c.18G>C	c.(16-18)CAG>CAC	p.Q6H		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	6					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						AGACACTGCAGATGGAGATCC	0.627													0	0	0	0.105934	0	13	38										C	13246039	G	C	13246039	3	2	70	1	0	0	0	0	1	0	0	0	10135	933	33	1	20	1	NACC1	19	13246039	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	465211	13246039	45882944	124	21953										
ZNF492	57615	broad.mit.edu	37	chr19	22847622	22847622	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctcacaccttactacacataAgagaattcatactggagaga	6	10	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:22847622A>C	uc002nqw.3	+	4	1395	c.1151A>C	c.(1150-1152)AAG>ACG	p.K384T		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	384	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACTACACATAAGAGAATTCAT	0.378													0	0	0	0.069288	0	16	52										C	22847622	A	C	22847622	3	2	70	1	0	0	0	0	1	0	0	0	17940	72	3	5	1161	5	ZNF492	19	22847622	Missense_Mutation	SNP	A	TCGA-E7-A3X6-01A-12D-A22Z-08	9601583	22847622	36281361	125	21954										
MAP4K1	11184	broad.mit.edu	37	chr19	39098807	39098807	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gcttcctgaactccatgtgcCgccctagggtgggtggggga	16	11	0	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:39098807C>T	uc002oix.1	-	14	1118	c.1010G>A	c.(1009-1011)CGG>CAG	p.R337Q	MAP4K1_uc002oiw.1_5'Flank|MAP4K1_uc002oiy.1_Missense_Mutation_p.R337Q|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	337					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCCATGTGCCGCCCTAGGGT	0.602													0	0	0	0.069234	0	9	25										T	39098807	C	T	39098807	3	4	70	1	0	0	0	0	1	0	0	0	9259	652	23	2	1629	2	MAP4K1	19	39098807	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	16251185	39098807	20030176	126	21955										
MED29	55588	broad.mit.edu	37	chr19	39883109	39883109	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttttgttttgactagaccttGatgaaggttgcggcccaaaa	10	7	0	4			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:39883109G>C	uc002olf.2	+	2	322	c.285G>C	c.(283-285)TTG>TTC	p.L95F	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Missense_Mutation_p.L95F|MED29_uc010xux.1_Intron	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	74	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ACTAGACCTTGATGAAGGTTG	0.433													0	0	0	0.076483	0	23	46										C	39883109	G	C	39883109	3	2	70	1	0	0	0	0	1	0	0	0	9447	1281	45	1	291	1	MED29	19	39883109	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	784302	39883109	19245874	127	21956										
PNMAL2	57469	broad.mit.edu	37	chr19	46998146	46998146	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gtcggaagagtcctcggcctCactcctcgcgggagcagacg	14	14	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:46998146C>T	uc002pes.2	-	1	1024	c.577G>A	c.(577-579)GAG>AAG	p.E193K	uc002peu.1_Missense_Mutation_p.S86L	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	193										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TCCTCGGCCTCACTCCTCGCG	0.647													0	0	0	0.043863	0	20	37										T	46998146	C	T	46998146	3	4	70	1	0	0	0	0	1	0	0	0	12158	835	29	1	1334	1	PNMAL2	19	46998146	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	7115037	46998146	12130837	128	21957										
KCNC3	3748	broad.mit.edu	37	chr19	50826951	50826951	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	gcttgaagatgcgcaggatgCggacgaagcggaccacccgc	15	12	0	2	rs104894699		TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:50826951C>T	uc002pru.1	-	2	1554	c.1259G>A	c.(1258-1260)CGC>CAC	p.R420H	KCNC3_uc002prt.1_Missense_Mutation_p.R56H	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	420	Helical; Voltage-sensor; Name=Segment S4; (Potential).		R -> H (in SCA13; loss of channel activity).		cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GCGCAGGATGCGGACGAAGCG	0.657													0	0	0	0.020292	0	12	44										T	50826951	C	T	50826951	3	4	70	1	0	0	0	0	1	0	0	0	8016	768	27	2	1026	2	KCNC3	19	50826951	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	3828805	50826951	8302032	129	21958										
LILRA4	23547	broad.mit.edu	37	chr19	54849825	54849825	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttaatatgtgcctcgacattGagtttccctctttatccaga	6	10	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:54849825G>C	uc002qfj.2	-	3	254	c.197C>G	c.(196-198)TCA>TGA	p.S66*	LILRA4_uc002qfi.2_5'UTR	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	66	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCTCGACATTGAGTTTCCCTC	0.532													0	0	0	0.104719	0	40	110										C	54849825	G	C	54849825	4	2	70	1	0	0	0	0	0	1	0	0	8787	1294	45	1	1326	1	LILRA4	19	54849825	Nonsense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	4022874	54849825	4279158	130	21959										
ZNF543	125919	broad.mit.edu	37	chr19	57840563	57840563	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ttttatgactgcacagacttCagtcaacatccaggaacttt	6	10	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr19:57840563C>T	uc002qoi.1	+	4	2078	c.1733C>T	c.(1732-1734)TCA>TTA	p.S578L		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	578					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCACAGACTTCAGTCAACATC	0.423													0	0	0	0.059317	0	37	62										T	57840563	C	T	57840563	3	4	70	1	0	0	0	0	1	0	0	0	17973	838	29	1	1747	1	ZNF543	19	57840563	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	2990738	57840563	1288420	131	21960										
KCNB1	3745	broad.mit.edu	37	chr20	48098781	48098781	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tcaaagaagtactcgttgtcGtcgaggctgtagtcatcgca	11	9	2	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr20:48098781G>A	uc002xur.1	-	1	401	c.237C>T	c.(235-237)GAC>GAT	p.D79D	KCNB1_uc002xus.1_Silent_p.D79D	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	79	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ACTCGTTGTCGTCGAGGCTGT	0.647													0	0	0	0.028581	0	16	21										A	48098781	G	A	48098781	2	1	70	1	0	0	0	0	0	0	0	1	8012	1136	40	2		2	KCNB1	20	48098781	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		48098781	14926739	132	21961										
NFATC2	4773	broad.mit.edu	37	chr20	50051848	50051848	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	agggatctcaacaaaaagcaTgttctataaggaaggagttg	11	5	2	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr20:50051848T>C	uc002xwd.2	-	8	2129	c.1909A>G	c.(1909-1911)ATG>GTG	p.M637V	NFATC2_uc002xwc.2_Missense_Mutation_p.M637V|NFATC2_uc010zyv.1_Missense_Mutation_p.M418V|NFATC2_uc010zyw.1_Missense_Mutation_p.M418V|NFATC2_uc010zyx.1_Missense_Mutation_p.M617V|NFATC2_uc010zyy.1_Missense_Mutation_p.M418V|NFATC2_uc010zyz.1_Missense_Mutation_p.M418V|NFATC2_uc002xwe.2_Missense_Mutation_p.M617V	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	637					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					ACAAAAAGCATGTTCTATAAG	0.453													0	0	0	0.048971	0	51	103										C	50051848	T	C	50051848	3	2	70	1	0	0	0	0	1	0	0	0	10362	1464	51	5	928	5	NFATC2	20	50051848	Missense_Mutation	SNP	T	TCGA-E7-A3X6-01A-12D-A22Z-08	1953067	50051848	12973672	133	21962										
SRMS	6725	broad.mit.edu	37	chr20	62173828	62173828	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgatcgccacgggcagggagCccagccacaggccttcccac	12	17	0	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr20:62173828C>T	uc002yfi.1	-	4	793	c.752G>A	c.(751-753)GGC>GAC	p.G251D		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	251	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GGGCAGGGAGCCCAGCCACAG	0.672													0	0	0	0.080935	0	10	24										T	62173828	C	T	62173828	3	4	70	1	0	0	0	0	1	0	0	0	15151	739	26	2	734	2	SRMS	20	62173828	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	12121980	62173828	851692	134	21963										
RWDD2B	10069	broad.mit.edu	37	chr21	30380387	30380387	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccatgacaatgtttttgcagGaatgcagtcagatctgtgtt	10	7	2	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr21:30380387G>A	uc002yms.2	-	4	507	c.420C>T	c.(418-420)TTC>TTT	p.F140F	RWDD2B_uc002ymt.2_Silent_p.F111F|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Silent_p.F60F	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	140	RWD.										0						GTTTTTGCAGGAATGCAGTCA	0.398													0	0	0	0.055883	0	20	59										A	30380387	G	A	30380387	2	1	70	1	0	0	0	0	0	0	0	1	13756	1165	41	1		1	RWDD2B	21	30380387	Silent	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08		30380387	17749508	135	21964										
RSPH1	89765	broad.mit.edu	37	chr21	43897508	43897508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tttgggtagctttccattttGgaacaacagttactaattct	7	7	1	0			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr21:43897508G>A	uc002zbg.2	-	7	725	c.620C>T	c.(619-621)CCA>CTA	p.P207L		NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	207					meiosis	cytosol|nucleus				ovary(1)	1						TTTCCATTTTGGAACAACAGT	0.453													0	0	0	0.054565	0	30	61										A	43897508	G	A	43897508	3	1	70	1	0	0	0	0	1	0	0	0	13702	1348	47	2	321	2	RSPH1	21	43897508	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	13517121	43897508	4232387	136	21965										
SLC19A1	6573	broad.mit.edu	37	chr21	46951324	46951324	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	cagcagcgtggaggcagcatCtgccgcgccgttgtagaccc	14	14	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr21:46951324C>T	uc002zhl.1	-	3	1047	c.928G>A	c.(928-930)GAT>AAT	p.D310N	SLC19A1_uc010gpy.1_Missense_Mutation_p.D310N|SLC19A1_uc011aft.1_Missense_Mutation_p.D270N|SLC19A1_uc002zhm.1_Missense_Mutation_p.D310N|SLC19A1_uc010gpz.1_Missense_Mutation_p.D189N	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	310	Helical; (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GAGGCAGCATCTGCCGCGCCG	0.662													0	0	0	0.037714	0	28	78										T	46951324	C	T	46951324	3	4	70	1	0	0	0	0	1	0	0	0	14428	913	32	1	863	1	SLC19A1	21	46951324	Missense_Mutation	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	3053816	46951324	1178571	137	21966										
THOC5	8563	broad.mit.edu	37	chr22	29917011	29917011	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ctttatcaaactgatactgaTtggctggattcggagttttc	9	7	1	2			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr22:29917011T>C	uc003afr.2	-	14	1588	c.1253A>G	c.(1252-1254)AAT>AGT	p.N418S	THOC5_uc003afq.2_Missense_Mutation_p.N79S|THOC5_uc003afs.2_Missense_Mutation_p.N418S|THOC5_uc003aft.2_Missense_Mutation_p.N418S|THOC5_uc003afu.2_Missense_Mutation_p.N418S|THOC5_uc010gvo.2_Missense_Mutation_p.N162S	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	418					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						CTGATACTGATTGGCTGGATT	0.463													0	0	0	0.048971	0	67	153										C	29917011	T	C	29917011	3	2	70	1	0	0	0	0	1	0	0	0	15865	1493	52	5	830	5	THOC5	22	29917011	Missense_Mutation	SNP	T	TCGA-E7-A3X6-01A-12D-A22Z-08		29917011	21387555	138	21967										
ASCC2	84164	broad.mit.edu	37	chr22	30198142	30198142	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	ccttcacttgggagatgagaGagtccagttccaccccacac	9	14	1	3			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr22:30198142G>A	uc003agr.2	-	14	1514	c.1409C>T	c.(1408-1410)TCT>TTT	p.S470F	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Missense_Mutation_p.S470F|ASCC2_uc011akr.1_Missense_Mutation_p.S394F	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	470	CUE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GGAGATGAGAGAGTCCAGTTC	0.607													0	0	0	0.037714	0	27	46										A	30198142	G	A	30198142	3	1	70	1	0	0	0	0	1	0	0	0	1032	942	33	1	892	1	ASCC2	22	30198142	Missense_Mutation	SNP	G	TCGA-E7-A3X6-01A-12D-A22Z-08	281131	30198142	21106424	139	21968										
APOBEC3H	164668	broad.mit.edu	37	chr22	39497957	39497957	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.485507246376812	67	4.37106472958821e-28	4.36528786395611	5.36960600375235	3.75974310319661	0.50410713338331	0.689830814103477	52	tgggaaaactttgtggaccaCgagaaaccgctttccttcaa	9	10	1	1			TCGA-E7-A3X6-01A-12D-A22Z-08	TCGA-E7-A3X6-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81697c0-54af-4f8a-88c4-36934f163f5f	77e72aa6-bc4a-4382-9a91-4f882d28c906	g.chr22:39497957C>T	uc011aoh.1	+	4	519	c.453C>T	c.(451-453)CAC>CAT	p.H151H	APOBEC3H_uc011aoi.1_RNA|APOBEC3H_uc003axa.3_RNA	NM_181773	NP_861438	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	151					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Melanoma(58;0.04)					TTGTGGACCACGAGAAACCGC	0.522													0	0	0	0.030593	0	28	52										T	39497957	C	T	39497957	2	4	70	1	0	0	0	0	0	0	0	1	795	535	19	2		2	APOBEC3H	22	39497957	Silent	SNP	C	TCGA-E7-A3X6-01A-12D-A22Z-08	9299815	39497957	11806609	140	21969										
EPHA8	2046	broad.mit.edu	37	chr1	22922604	22922604	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgccctcctctgcaggcactGtggctacagcaaggccttcc	10	16	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:22922604G>T	uc001bfx.1	+	9	1828	c.1703G>T	c.(1702-1704)TGT>TTT	p.C568F		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	568	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGCAGGCACTGTGGCTACAGC	0.637													1	0	8.16277e-20	0.027894	8.86362e-20	40	50										T	22922604	G	T	22922604	3	4	71	1	0	0	0	0	1	0	0	0	5173	1377	48	4	1910	4	EPHA8	1	22922604	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		22922604	226328017	1	21970										
CSMD2	114784	broad.mit.edu	37	chr1	34209159	34209159	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	catagtcctctgggtagttgGgagacaggacaaccccagac	12	11	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:34209159G>A	uc001bxn.1	-	14	1804	c.1775C>T	c.(1774-1776)CCC>CTC	p.P592L	CSMD2_uc001bxm.1_Missense_Mutation_p.P632L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	592	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGGTAGTTGGGAGACAGGAC	0.572													0	0	0	0.038147	0	8	102										A	34209159	G	A	34209159	3	1	71	1	0	0	0	0	1	0	0	0	3945	1232	43	2	8912	2	CSMD2	1	34209159	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	11286555	34209159	215041462	2	21971										
BNIPL	149428	broad.mit.edu	37	chr1	151018593	151018593	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggacagcctgggggagctggCccaactcatatccctggatc	13	13	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:151018593C>A	uc001ewl.2	+	9	1162	c.989C>A	c.(988-990)GCC>GAC	p.A330D	BNIPL_uc009wmi.2_Missense_Mutation_p.A248D|BNIPL_uc009wmj.2_RNA|C1orf56_uc001ewn.2_5'Flank	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	330	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGGGAGCTGGCCCAACTCATA	0.453													1	0	7.04047e-22	0.023175	7.72297e-22	37	40										A	151018593	C	A	151018593	3	1	71	1	0	0	0	0	1	0	0	0	1480	739	26	4	1023	4	BNIPL	1	151018593	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	116809434	151018593	98232028	3	21972										
FLG	2312	broad.mit.edu	37	chr1	152280711	152280711	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agtgagtgtctagagctgtcGgcccaagaggaagcttcatg	14	8	2	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:152280711G>T	uc001ezu.1	-	3	6687	c.6651C>A	c.(6649-6651)GCC>GCA	p.A2217A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2217	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGAGCTGTCGGCCCAAGAGG	0.552									Ichthyosis				1	0	4.53876e-58	0.048971	5.30344e-58	206	656										T	152280711	G	T	152280711	2	4	71	1	0	0	0	0	0	0	0	1	5922	1103	39	4		4	FLG	1	152280711	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1262118	152280711	96969910	4	21973										
ADAM15	8751	broad.mit.edu	37	chr1	155030474	155030474	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggcaagctgtgtgcatgcacGggcgttgtgcctcctatgcc	14	12	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:155030474G>A	uc001fgr.1	+	14	1665	c.1564G>A	c.(1564-1566)GGG>AGG	p.G522R	ADAM15_uc001fgq.1_Missense_Mutation_p.G207R|ADAM15_uc010pet.1_Missense_Mutation_p.G506R|ADAM15_uc010peu.1_Missense_Mutation_p.G539R|ADAM15_uc001fgt.1_Missense_Mutation_p.G522R|ADAM15_uc010pev.1_Missense_Mutation_p.G532R|ADAM15_uc001fgs.1_Missense_Mutation_p.G522R|ADAM15_uc001fgu.1_Missense_Mutation_p.G522R|ADAM15_uc001fgw.1_Missense_Mutation_p.G522R|ADAM15_uc001fgv.1_Missense_Mutation_p.G522R|ADAM15_uc001fgx.1_Missense_Mutation_p.G522R|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	522	Extracellular (Potential).|Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GTGCATGCACGGGCGTTGTGC	0.632													0	0	0	0.027894	0	39	108										A	155030474	G	A	155030474	3	1	71	1	0	0	0	0	1	0	0	0	237	1116	39	2	1618	2	ADAM15	1	155030474	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	2749763	155030474	94220147	5	21974										
F5	2153	broad.mit.edu	37	chr1	169511786	169511786	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agcaccaagtgaaagtagacGtatccctgtgacatctggct	10	10	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:169511786G>A	uc001ggg.1	-	13	2687	c.2542C>T	c.(2542-2544)CGT>TGT	p.R848C		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	848	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GAAAGTAGACGTATCCCTGTG	0.458													0	0	0	0.048971	0	97	233										A	169511786	G	A	169511786	3	1	71	1	0	0	0	0	1	0	0	0	5348	1145	40	2	4184	2	F5	1	169511786	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	14481312	169511786	79738835	6	21975										
HMCN1	83872	broad.mit.edu	37	chr1	186014962	186014962	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccttgctgaagaaaccaggCctcagtatatctgaaaatag	8	10	2	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:186014962C>T	uc001grq.1	+	41	6676	c.6447C>T	c.(6445-6447)GGC>GGT	p.G2149G		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2149	Ig-like C2-type 19.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGAAACCAGGCCTCAGTATAT	0.378													0	0	0	0.021523	0	25	58										T	186014962	C	T	186014962	2	4	71	1	0	0	0	0	0	0	0	1	7220	726	26	2		2	HMCN1	1	186014962	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	16503176	186014962	63235659	7	21976										
HMCN1	83872	broad.mit.edu	37	chr1	186158668	186158668	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgcctcaagaactgtccaccCaatgatttggaatgtgcctt	8	11	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:186158668C>T	uc001grq.1	+	107	16795	c.16566C>T	c.(16564-16566)CCC>CCT	p.P5522P	HMCN1_uc001grs.1_Silent_p.P974P	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5522					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACTGTCCACCCAATGATTTGG	0.438													0	0	0	0.048971	0	47	61										T	186158668	C	T	186158668	2	4	71	1	0	0	0	0	0	0	0	1	7220	581	21	2		2	HMCN1	1	186158668	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	143706	186158668	63091953	8	21977										
RGS13	6003	broad.mit.edu	37	chr1	192628536	192628536	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gaacccactgaaacatgtttTgaagaagctcagaaaatagt	8	7	1	4			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:192628536T>C	uc001gsj.2	+	7	644	c.363T>C	c.(361-363)TTT>TTC	p.F121F	RGS13_uc001gsk.2_Silent_p.F121F	NM_002927	NP_002918	O14921	RGS13_HUMAN	regulator of G-protein signalling 13	121	RGS.					plasma membrane	GTPase activator activity|signal transducer activity				0						AAACATGTTTTGAAGAAGCTC	0.353													0	0	0	0.048971	0	45	25										C	192628536	T	C	192628536	2	2	71	1	0	0	0	0	0	0	0	1	13296	1809	63	5		5	RGS13	1	192628536	Silent	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	6469868	192628536	56622085	9	21978										
ZBTB41	360023	broad.mit.edu	37	chr1	197128821	197128821	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tacttcagcagatacattctGtaacatcgtcttggcttccg	7	11	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:197128821G>T	uc001gtx.1	-	10	2467	c.2398C>A	c.(2398-2400)CAG>AAG	p.Q800K	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	800					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						GATACATTCTGTAACATCGTC	0.443													1	0	5.57489e-27	0.048971	6.2754e-27	56	125										T	197128821	G	T	197128821	3	4	71	1	0	0	0	0	1	0	0	0	17540	1386	48	4	335	4	ZBTB41	1	197128821	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	4500285	197128821	52121800	10	21979										
USH2A	7399	broad.mit.edu	37	chr1	216498861	216498861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gctgtgccaaagggtggaccCgcgggtggctgccagggcaa	18	11	0	0	rs3820464		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:216498861C>T	uc001hku.1	-	6	1316	c.929G>A	c.(928-930)CGG>CAG	p.R310Q	USH2A_uc001hkv.2_Missense_Mutation_p.R310Q	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	310	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGGTGGACCCGCGGGTGGCT	0.532										HNSCC(13;0.011)			0	0	0	0.048971	0	93	60										T	216498861	C	T	216498861	3	4	71	1	0	0	0	0	1	0	0	0	17033	652	23	2	14961	2	USH2A	1	216498861	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	19370040	216498861	32751760	11	21980										
C1orf95	375057	broad.mit.edu	37	chr1	226784667	226784667	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcatcttctggggcatggacAtggtcatccttgccagtgag	13	10	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:226784667A>G	uc010pvn.1	+	2	472	c.367A>G	c.(367-369)ATG>GTG	p.M123V		NM_001003665	NP_001003665	Q69YW2	CA095_HUMAN	hypothetical protein LOC375057	123						integral to membrane				ovary(1)	1	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		GGGCATGGACATGGTCATCCT	0.592													0	0	0	0.013537	0	13	200										G	226784667	A	G	226784667	3	3	71	1	0	0	0	0	1	0	0	0	2072	217	8	5	373	5	C1orf95	1	226784667	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	10285806	226784667	22465954	12	21981										
RYR2	6262	broad.mit.edu	37	chr1	237730002	237730002	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tggagacatgagggttggttGgagtcgtcctggttgtcaac	16	6	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:237730002G>A	uc001hyl.1	+	28	3470	c.3350G>A	c.(3349-3351)TGG>TAG	p.W1117*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1117	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGGTTGGTTGGAGTCGTCCT	0.532													0	0	0	0.048971	0	114	325										A	237730002	G	A	237730002	4	1	71	1	0	0	0	0	0	1	0	0	13769	1357	47	2	3460	2	RYR2	1	237730002	Nonsense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	10945335	237730002	11520619	13	21982										
OR2W3	343171	broad.mit.edu	37	chr1	248059029	248059029	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggcaacaccaccatcatcctGgtgtcccggctggaccccca	9	18	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:248059029G>A	uc001idp.1	+	3	410	c.141G>A	c.(139-141)CTG>CTA	p.L47L	OR2W3_uc010pzb.1_Silent_p.L47L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCATCATCCTGGTGTCCCGGC	0.592													0	0	0	0.028581	0	15	343										A	248059029	G	A	248059029	2	1	71	1	0	0	0	0	0	0	0	1	11033	1335	47	2		2	OR2W3	1	248059029	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	10329027	248059029	1191592	14	21983										
OR2L8	391190	broad.mit.edu	37	chr1	248113003	248113003	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tcttctacaccatcctcaccCcaatgctcaaccccatcatc	1	20	5	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:248113003C>T	uc001idt.1	+	1	844	c.844C>T	c.(844-846)CCA>TCA	p.P282S	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CATCCTCACCCCAATGCTCAA	0.483													0	0	0	0.019004	0	32	108										T	248113003	C	T	248113003	3	4	71	1	0	0	0	0	1	0	0	0	11009	623	22	2	846	2	OR2L8	1	248113003	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	53974	248113003	1137618	15	21984										
PQLC3	130814	broad.mit.edu	37	chr2	11300786	11300786	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tctgtatctttcattttaacGggaacgtgaagcaggccact	9	9	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:11300786G>A	uc002rbc.2	+	3	395	c.262G>A	c.(262-264)GGG>AGG	p.G88R	PQLC3_uc010yjk.1_Missense_Mutation_p.G88R	NM_152391	NP_689604	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3 precursor	88						integral to membrane					0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)		TCATTTTAACGGGAACGTGAA	0.517													0	0	0	0.023175	0	39	73										A	11300786	G	A	11300786	3	1	71	1	0	0	0	0	1	0	0	0	12420	1116	39	2	272	2	PQLC3	2	11300786	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		11300786	231898587	16	21985										
C2orf86	51057	broad.mit.edu	37	chr2	63380641	63380641	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	taccattaccttctgcattaCaggtattagtcatcaaaaat	4	9	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:63380641C>T	uc002sch.2	-	16	2593	c.2147G>A	c.(2146-2148)TGT>TAT	p.C716Y	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.C557Y|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.C524Y	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	716					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TTCTGCATTACAGGTATTAGT	0.299													0	0	0	0.055883	0	22	25										T	63380641	C	T	63380641	3	4	71	1	0	0	0	0	1	0	0	0	2201	478	17	2	105	2	C2orf86	2	63380641	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	52079855	63380641	179818732	17	21986										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71357850	71357850	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agcggtgtctgacggaagtcGgcaaagccacgggtcggccc	16	12	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:71357850G>T	uc002sht.1	+	1	407	c.55G>T	c.(55-57)GGC>TGC	p.G19C	MCEE_uc002shs.2_5'Flank|MPHOSPH10_uc010feb.1_Missense_Mutation_p.G19C	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	19					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GACGGAAGTCGGCAAAGCCAC	0.672													1	0	2.21704e-12	0.016522	2.35972e-12	20	20										T	71357850	G	T	71357850	3	4	71	1	0	0	0	0	1	0	0	0	9725	1116	39	4	57	4	MPHOSPH10	2	71357850	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	7977209	71357850	171841523	18	21987										
NCAPH	23397	broad.mit.edu	37	chr2	97035169	97035169	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ccctttctttccagcctgccCcctgtcatggctcagaacct	6	18	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:97035169C>T	uc002svz.1	+	17	2181	c.2097C>T	c.(2095-2097)CCC>CCT	p.P699P	NCAPH_uc010yum.1_Silent_p.P675P|NCAPH_uc010fhw.1_Silent_p.P688P|NCAPH_uc010yun.1_Silent_p.P563P|NCAPH_uc002swa.1_Silent_p.P294P	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	699					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CCAGCCTGCCCCCTGTCATGG	0.428													0	0	0	0.033182	0	39	76										T	97035169	C	T	97035169	2	4	71	1	0	0	0	0	0	0	0	1	10209	610	22	2		2	NCAPH	2	97035169	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	25677319	97035169	146164204	19	21988										
ZC3H6	376940	broad.mit.edu	37	chr2	113074110	113074110	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttattaatcagcacacagtgGaacacaaaggaaaacaaatc	6	8	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:113074110G>A	uc002thq.1	+	6	1205	c.811G>A	c.(811-813)GAA>AAA	p.E271K		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	271							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						GCACACAGTGGAACACAAAGG	0.318													0	0	0	0.016723	0	13	16										A	113074110	G	A	113074110	3	1	71	1	0	0	0	0	1	0	0	0	17568	1175	41	1	833	1	ZC3H6	2	113074110	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	16038941	113074110	130125263	20	21989										
POTEE	445582	broad.mit.edu	37	chr2	132021608	132021608	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gactctggtgacggggtcacCcacactgtgcccatctatga	11	13	3	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:132021608C>T	uc002tsn.2	+	15	2632	c.2580C>T	c.(2578-2580)ACC>ACT	p.T860T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.T460T|POTEE_uc002tsl.2_Silent_p.T442T|POTEE_uc010fmy.1_Silent_p.T324T	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	860	Actin-like.						ATP binding				0						ACGGGGTCACCCACACTGTGC	0.617													0	0	0	0.048971	0	61	121										T	132021608	C	T	132021608	2	4	71	1	0	0	0	0	0	0	0	1	12264	610	22	2		2	POTEE	2	132021608	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	18947498	132021608	111177765	21	21990										
NEB	4703	broad.mit.edu	37	chr2	152420419	152420419	+	Frame_Shift_Del	DEL	C	C	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgtagccataggccttggtgCcctcccacgcccctttatac							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:152420419delC	uc010fnx.2	-	90	13585	c.13394delG	c.(13393-13395)GGCfs	p.G4465fs	NEB_uc002txr.2_Frame_Shift_Del_p.G888fs	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4465	Nebulin 122.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGCCTTGGTGCCCTCCCACGC	0.443																		10	19	---	---								-	152420419	C	-	152420419	7	5	71	1	0	1	0	1	0	0	0	0	10302	739	26	0	7449	0	NEB	2	152420419	Frame_Shift_Del	DEL	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	20398811	152420419	90778954	22	21991										
PGAP1	80055	broad.mit.edu	37	chr2	197781295	197781295	+	Frame_Shift_Del	DEL	T	T	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atgtcctctgcttttctaagTgcaatggagccaatagaacg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:197781295delT	uc002utw.2	-	3	438	c.324delA	c.(322-324)GCAfs	p.A108fs	PGAP1_uc002utx.2_5'UTR|PGAP1_uc002uty.1_Frame_Shift_Del_p.A108fs|PGAP1_uc010zgv.1_RNA|PGAP1_uc010fsj.2_5'UTR	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	108	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						CTTTTCTAAGTGCAATGGAGC	0.378																		28	26	---	---								-	197781295	T	-	197781295	7	5	71	1	0	1	0	1	0	0	0	0	11777	1683	59	0	2544	0	PGAP1	2	197781295	Frame_Shift_Del	DEL	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	45360876	197781295	45418078	23	21992										
COL4A4	1286	broad.mit.edu	37	chr2	227906897	227906897	+	Frame_Shift_Del	DEL	C	C	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aggacctggtatccctggatCcccctggaggcctcttggcc							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:227906897delC	uc010zlt.1	-	37	4126	c.3472delG	c.(3472-3474)GATfs	p.D1158fs		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1158	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATCCCTGGATCCCCCTGGAGG	0.542																		41	98	---	---								-	227906897	C	-	227906897	7	5	71	1	0	1	0	1	0	0	0	0	3693	855	30	0	1648	0	COL4A4	2	227906897	Frame_Shift_Del	DEL	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	30125602	227906897	15292476	24	21993										
SPHKAP	80309	broad.mit.edu	37	chr2	228860382	228860382	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttctgtggaggcttcagcctCtggtacatctctggtatcaa	10	10	5	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:228860382C>T	uc002vpq.2	-	8	4524	c.4477G>A	c.(4477-4479)GAG>AAG	p.E1493K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E1493K|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1493						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTTCAGCCTCTGGTACATCT	0.557													0	0	0	0.014323	0	23	45										T	228860382	C	T	228860382	3	4	71	1	0	0	0	0	1	0	0	0	15047	922	32	1	645	1	SPHKAP	2	228860382	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	953485	228860382	14338991	25	21994										
COL6A3	1293	broad.mit.edu	37	chr2	238287358	238287358	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atcagctgctgaggcaaagcTggcagggagctgaaatcatc	13	9	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:238287358T>C	uc002vwl.2	-	6	2703	c.2418A>G	c.(2416-2418)CCA>CCG	p.P806P	COL6A3_uc002vwo.2_Silent_p.P600P|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Silent_p.P600P|COL6A3_uc002vwr.2_Silent_p.P399P|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	806	VWFA 4.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GAGGCAAAGCTGGCAGGGAGC	0.527													0	0	0	0.021022	0	39	65										C	238287358	T	C	238287358	2	2	71	1	0	0	0	0	0	0	0	1	3701	1567	55	5		5	COL6A3	2	238287358	Silent	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	9426976	238287358	4912015	26	21995										
SCN11A	11280	broad.mit.edu	37	chr3	38888718	38888718	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atcttcacccaaagggtcctCactttcttcagtggctgtat	7	12	5	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:38888718C>T	uc011ays.1	-	26	5042	c.4843G>A	c.(4843-4845)GAG>AAG	p.E1615K		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1615					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAAGGGTCCTCACTTTCTTCA	0.368													0	0	0	0.013537	0	13	144										T	38888718	C	T	38888718	3	4	71	1	0	0	0	0	1	0	0	0	13913	835	29	1	536	1	SCN11A	3	38888718	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		38888718	159133712	27	21996										
SCN11A	11280	broad.mit.edu	37	chr3	38926797	38926797	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acctttgggcaaacatctctCtggttgctttttgggaacca	9	10	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:38926797C>G	uc011ays.1	-	17	3245	c.3046G>C	c.(3046-3048)GAG>CAG	p.E1016Q	SCN11A_uc010hhn.1_Missense_Mutation_p.E94Q	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1016					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAACATCTCTCTGGTTGCTTT	0.428													0	0	0	0.047766	0	8	80										G	38926797	C	G	38926797	3	3	71	1	0	0	0	0	1	0	0	0	13913	922	32	1	2369	1	SCN11A	3	38926797	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	38079	38926797	159095633	28	21997										
IQCF1	132141	broad.mit.edu	37	chr3	51929352	51929352	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cttcttttggttttctggggGctttcaagaaaaaaagaggg	12	5	3	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:51929352G>T	uc003dbv.2	-	4	270	c.172C>A	c.(172-174)CCC>ACC	p.P58T	IQCF1_uc003dbq.3_Intron	NM_152397	NP_689610	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	58										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTTTCTGGGGGCTTTCAAGAA	0.562													1	0	1.2476e-16	0.030593	1.34117e-16	30	42										T	51929352	G	T	51929352	3	4	71	1	0	0	0	0	1	0	0	0	7807	1217	42	4	449	4	IQCF1	3	51929352	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	13002555	51929352	146093078	29	21998										
ITIH4	3700	broad.mit.edu	37	chr3	52857966	52857966	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ccaggcagaagaggctgtacCggccacttacagcttcccgc	11	15	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:52857966C>A	uc003dfz.2	-	10	1262	c.1226G>T	c.(1225-1227)CGG>CTG	p.R409L	ITIH4_uc011bel.1_Missense_Mutation_p.R139L|ITIH4_uc003dfy.2_Missense_Mutation_p.R273L|ITIH4_uc011bem.1_Missense_Mutation_p.R409L|ITIH4_uc011ben.1_Missense_Mutation_p.R409L	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	409	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GAGGCTGTACCGGCCACTTAC	0.582													1	0	6.90743e-12	0.064281	7.31575e-12	34	75										A	52857966	C	A	52857966	3	1	71	1	0	0	0	0	1	0	0	0	7906	652	23	4	1626	4	ITIH4	3	52857966	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	928614	52857966	145164464	30	21999										
DNASE1L3	1776	broad.mit.edu	37	chr3	58186750	58186750	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cttccagcggtgtttcacgtCcgtgtagacctcaaccaact	8	14	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:58186750C>T	uc003djo.1	-	5	617	c.520G>A	c.(520-522)GAC>AAC	p.D174N	DNASE1L3_uc011bfd.1_Missense_Mutation_p.D144N|DNASE1L3_uc003djp.1_Missense_Mutation_p.D174N|DNASE1L3_uc003djq.1_Missense_Mutation_p.D174N	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	174					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		TGTTTCACGTCCGTGTAGACC	0.547													0	0	0	0.048971	0	100	175										T	58186750	C	T	58186750	3	4	71	1	0	0	0	0	1	0	0	0	4663	855	30	1	413	1	DNASE1L3	3	58186750	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	5328784	58186750	139835680	31	22000										
FAM19A4	151647	broad.mit.edu	37	chr3	68802170	68802170	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttgcttgatttggtggtgacCtagttggtaatgggggagaa	16	3	0	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:68802170C>T	uc003dnh.1	-	4	574	c.131_splice	c.e4-1	p.G44_splice	FAM19A4_uc003dni.1_Splice_Site_p.G44_splice	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine							extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TGGTGGTGACCTAGTTGGTAA	0.478													0	0	0	0.028581	0	16	29										T	68802170	C	T	68802170	5	4	71	1	0	0	0	0	0	0	1	0	5534	695	24	2	304	2	FAM19A4	3	68802170	Splice_Site	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	10615420	68802170	129220260	32	22001										
LMOD3	56203	broad.mit.edu	37	chr3	69168084	69168084	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tctgtcctgtacttcggggcCtgcgatggctttttcatcat	10	11	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:69168084C>T	uc003dns.2	-	2	1631	c.1422G>A	c.(1420-1422)CAG>CAA	p.Q474Q	LMOD3_uc003dnt.2_Silent_p.Q474Q	NM_198271	NP_938012	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	474						cytoplasm|cytoskeleton	tropomyosin binding			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		ACTTCGGGGCCTGCGATGGCT	0.562													0	0	0	0.009096	0	4	68										T	69168084	C	T	69168084	2	4	71	1	0	0	0	0	0	0	0	1	8858	680	24	2		2	LMOD3	3	69168084	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	365914	69168084	128854346	33	22002										
ZDHHC23	254887	broad.mit.edu	37	chr3	113667649	113667649	+	Translation_Start_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tcatggtgacaggtgcaaatCatgacacagaagggcagtat	12	7	2	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:113667649C>G	uc003eau.2	+	2	299	c.0C>G	c.(-2-2)ATCAT>ATGAT		ZDHHC23_uc003eav.2_Intron	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23							integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						AGGTGCAAATCATGACACAGA	0.483													0	0	0	0.030466	0	40	31										G	113667649	C	G	113667649	1	3	71	1	0	0	0	0	0	0	0	0	17611	841	29	1		1	ZDHHC23	3	113667649	Translation_Start_Site	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	44499565	113667649	84354781	34	22003										
FGFR3	2261	broad.mit.edu	37	chr4	1806088	1806089	+	Missense_Mutation	DNP	GG	GG	TT													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctggtggaggctgacgaggcGggcagtgtgtatgcaggcat					rs121913479		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			GG	TT	GG	GG		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:1806088_1806089GG>TT	uc003gdr.3	+	9	1363_1364	c.1107_1108GG>TT	c.(1105-1110)GCGGGC>GCTTGC	p.G370C	FGFR3_uc003gdu.2_Missense_Mutation_p.G372C|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.G370C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	370	Extracellular (Potential).		G -> C (in KERSEB, bladder cancer, keratinocytic non-epidermolytic nevus and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.G370C(125)|p.A369A(6)|p.A369_G370>VC(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTGACGAGGCGGGCAGTGTGTA	0.688		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.004672	0	101	150										TT	1806089	GG	TT	1806088	3	4	71	1	0	0	0	0	1	0	0	0	5867	1103	39	4	1292	4	FGFR3	4	1806088	Missense_Mutation	DNP	GG	TCGA-E7-A3Y1-01A-11D-A22Z-08		1806088	189348188	35	22004										
MXD4	10608	broad.mit.edu	37	chr4	2252898	2252898	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	caccgacagctgctccaggcGccgcttcaggaaacgatgct	11	15	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:2252898G>A	uc003geu.1	-	5	417	c.385C>T	c.(385-387)CGC>TGC	p.R129C		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	129					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						TGCTCCAGGCGCCGCTTCAGG	0.662													0	0	0	0.038147	0	8	10										A	2252898	G	A	2252898	3	1	71	1	0	0	0	0	1	0	0	0	10001	1087	38	2	252	2	MXD4	4	2252898	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	446810	2252898	188901378	36	22005										
ATP8A1	10396	broad.mit.edu	37	chr4	42545975	42545975	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	taactttccagatggagtgcGaacaatcactgacattcttt	7	9	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:42545975G>A	uc003gwr.2	-	20	1913	c.1681C>T	c.(1681-1683)CGC>TGC	p.R561C	ATP8A1_uc003gws.2_Missense_Mutation_p.R546C|ATP8A1_uc011byz.1_Missense_Mutation_p.R546C	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	561	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	GATGGAGTGCGAACAATCACT	0.338													0	0	0	0.043863	0	16	31										A	42545975	G	A	42545975	3	1	71	1	0	0	0	0	1	0	0	0	1192	1058	37	1	1885	1	ATP8A1	4	42545975	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	40293077	42545975	148608301	37	22006										
LRRC66	339977	broad.mit.edu	37	chr4	52862253	52862253	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tccttatgaggcttttcatgCgatgcagatgaatgggagga	13	6	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:52862253C>T	uc003gzi.2	-	4	948	c.935G>A	c.(934-936)CGC>CAC	p.R312H		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	312						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GCTTTTCATGCGATGCAGATG	0.562													0	0	0	0.041601	0	28	36										T	52862253	C	T	52862253	3	4	71	1	0	0	0	0	1	0	0	0	9018	768	27	2	1711	2	LRRC66	4	52862253	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	10316278	52862253	138292023	38	22007										
TECRL	253017	broad.mit.edu	37	chr4	65170940	65170940	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	caatccaagaagtaaatcccCagtaaaaggcacaactctgc	6	12	1	1	rs141462797		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:65170940C>A	uc003hcv.2	-	7	783	c.674G>T	c.(673-675)TGG>TTG	p.W225L	TECRL_uc003hcw.2_Missense_Mutation_p.W225L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	225	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						AGTAAATCCCCAGTAAAAGGC	0.294													1	0	0.00116845	0.021553	0.0011906	6	115										A	65170940	C	A	65170940	3	1	71	1	0	0	0	0	1	0	0	0	15743	595	21	4	441	4	TECRL	4	65170940	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	12308687	65170940	125983336	39	22008										
EXOSC9	5393	broad.mit.edu	37	chr4	122723018	122723018	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aaacctatgattataggaacAtcaggatctcatttggaaca	7	7	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:122723018A>T	uc003iea.2	+	2	211	c.103A>T	c.(103-105)ATC>TTC	p.I35F	EXOSC9_uc003idz.2_Missense_Mutation_p.I35F|EXOSC9_uc003ieb.2_Missense_Mutation_p.I19F|EXOSC9_uc010inp.1_5'Flank	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	35	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						TTATAGGAACATCAGGATCTC	0.318													0	0	0	0.059317	0	31	51										T	122723018	A	T	122723018	3	4	71	1	0	0	0	0	1	0	0	0	5321	217	8	5	109	5	EXOSC9	4	122723018	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	57552078	122723018	68431258	40	22009										
FAT4	79633	broad.mit.edu	37	chr4	126241857	126241857	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atattttcaagtctattgttGagaacattcccatcggtaca	6	8	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:126241857G>C	uc003ifj.3	+	1	4291	c.4291G>C	c.(4291-4293)GAG>CAG	p.E1431Q		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1431	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTCTATTGTTGAGAACATTCC	0.423													0	0	0	0.010729	0	12	154										C	126241857	G	C	126241857	3	2	71	1	0	0	0	0	1	0	0	0	5692	1291	45	1	4293	1	FAT4	4	126241857	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	3518839	126241857	64912419	41	22010										
ADAM29	11086	broad.mit.edu	37	chr4	175896928	175896928	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctccctgtgttcacctacacAgaccagggtgctatccttga	8	14	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:175896928A>T	uc003iuc.2	+	5	922	c.252A>T	c.(250-252)ACA>ACT	p.T84T	ADAM29_uc003iud.2_Silent_p.T84T|ADAM29_uc010irr.2_Silent_p.T84T|ADAM29_uc011cki.1_Silent_p.T84T	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	84					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TCACCTACACAGACCAGGGTG	0.478													0	0	0	0.049695	0	20	38										T	175896928	A	T	175896928	2	4	71	1	0	0	0	0	0	0	0	1	247	175	7	5		5	ADAM29	4	175896928	Silent	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	49655071	175896928	15257348	42	22011										
MTNR1A	4543	broad.mit.edu	37	chr4	187455151	187455151	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gttcagaggagcccagcaaaTggcaaaaaggacaaaaacca	10	9	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:187455151T>C	uc003izd.1	-	2	763	c.745A>G	c.(745-747)ATT>GTT	p.I249V		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	249	Helical; Name=6; (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GCCCAGCAAATGGCAAAAAGG	0.527													0	0	0	0.048971	0	51	109										C	187455151	T	C	187455151	3	2	71	1	0	0	0	0	1	0	0	0	9951	1464	51	5	311	5	MTNR1A	4	187455151	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	11558223	187455151	3699125	43	22012										
DNAH5	1767	broad.mit.edu	37	chr5	13766144	13766144	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	taaggattcctgccaggaggGcatggtacagcttttttcca	11	9	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:13766144G>A	uc003jfd.2	-	59	10084	c.10042C>T	c.(10042-10044)CCC>TCC	p.P3348S	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3348	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGCCAGGAGGGCATGGTACAG	0.468									Kartagener_syndrome				0	0	0	0.038147	0	8	147										A	13766144	G	A	13766144	3	1	71	1	0	0	0	0	1	0	0	0	4604	1203	42	2	3916	2	DNAH5	5	13766144	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		13766144	167149116	44	22013										
NPR3	4883	broad.mit.edu	37	chr5	32786414	32786414	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tggaaaacatcgggaattacGggaagattccatcagatccc	10	9	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:32786414G>A	uc003jhv.2	+	8	1807	c.1589G>A	c.(1588-1590)CGG>CAG	p.R530Q	NPR3_uc011cnz.1_Missense_Mutation_p.R313Q|NPR3_uc003jhu.2_Missense_Mutation_p.R529Q|C5orf23_uc003jhw.1_5'Flank	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	530	Cytoplasmic (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	CGGGAATTACGGGAAGATTCC	0.418													0	0	0	0.038147	0	7	13										A	32786414	G	A	32786414	3	1	71	1	0	0	0	0	1	0	0	0	10596	1116	39	2	1616	2	NPR3	5	32786414	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	19020270	32786414	148128846	45	22014										
ADAMTS12	81792	broad.mit.edu	37	chr5	33576479	33576479	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttggctggggagcagtccttCcattactgtgctgaagggtg	15	8	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:33576479C>G	uc003jia.1	-	19	3815	c.3652G>C	c.(3652-3654)GAA>CAA	p.E1218Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E1133Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1218	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGCAGTCCTTCCATTACTGTG	0.542										HNSCC(64;0.19)			0	0	0	0.047766	0	9	145										G	33576479	C	G	33576479	3	3	71	1	0	0	0	0	1	0	0	0	257	864	30	1	1156	1	ADAMTS12	5	33576479	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	790065	33576479	147338781	46	22015										
ADAMTS12	81792	broad.mit.edu	37	chr5	33576554	33576554	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tggaggtgcaagtggcatttCtgtactttccactggagcgt	13	8	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:33576554C>G	uc003jia.1	-	19	3740	c.3577G>C	c.(3577-3579)GAA>CAA	p.E1193Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E1108Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1193	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGTGGCATTTCTGTACTTTCC	0.512										HNSCC(64;0.19)			0	0	0	0.043863	0	16	140										G	33576554	C	G	33576554	3	3	71	1	0	0	0	0	1	0	0	0	257	922	32	1	1231	1	ADAMTS12	5	33576554	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	75	33576554	147338706	47	22016										
ADAMTS12	81792	broad.mit.edu	37	chr5	33881544	33881544	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	actggcatctactcggactgGacccaccacgtggtattctg	10	13	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:33881544G>T	uc003jia.1	-	2	332	c.169C>A	c.(169-171)CCA>ACA	p.P57T	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P57T|ADAMTS12_uc003jib.1_Missense_Mutation_p.P57T	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	57					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACTCGGACTGGACCCACCACG	0.488										HNSCC(64;0.19)			1	0	6.40141e-05	0.010729	6.55383e-05	12	213										T	33881544	G	T	33881544	3	4	71	1	0	0	0	0	1	0	0	0	257	1174	41	3	4707	3	ADAMTS12	5	33881544	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	304990	33881544	147033716	48	22017										
PARP8	79668	broad.mit.edu	37	chr5	50074470	50074470	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acactgttcacttacacagtAtttaaatggcccaggttagt	7	9	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:50074470A>G	uc003jon.3	+	10	838	c.656A>G	c.(655-657)TAT>TGT	p.Y219C	PARP8_uc011cpz.1_Missense_Mutation_p.Y111C|PARP8_uc003joo.2_Missense_Mutation_p.Y219C|PARP8_uc003jop.2_Missense_Mutation_p.Y219C	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	219						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				CTTACACAGTATTTAAATGGC	0.323													0	0	0	0.009096	0	4	22										G	50074470	A	G	50074470	3	3	71	1	0	0	0	0	1	0	0	0	11465	449	16	5	690	5	PARP8	5	50074470	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	16192926	50074470	130840790	49	22018										
ANKRD55	79722	broad.mit.edu	37	chr5	55422846	55422846	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgccgctgcgatatgtacacAtgtcttcccactctcatcat	6	14	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:55422846A>G	uc003jqu.2	-	8	852	c.700T>C	c.(700-702)TGT>CGT	p.C234R		NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	233	ANK 7.									skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				ATATGTACACATGTCTTCCCA	0.498													0	0	0	0.048971	0	60	122										G	55422846	A	G	55422846	3	3	71	1	0	0	0	0	1	0	0	0	681	217	8	5	1164	5	ANKRD55	5	55422846	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	5348376	55422846	125492414	50	22019										
ADAMTS6	11174	broad.mit.edu	37	chr5	64447760	64447760	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggcaataagccactttattcAcatctttgcactctaacgaa	5	11	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:64447760A>G	uc003jtp.2	-	25	4071	c.3257T>C	c.(3256-3258)GTG>GCG	p.V1086A	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1086	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CACTTTATTCACATCTTTGCA	0.458													0	0	0	0.030593	0	30	52										G	64447760	A	G	64447760	3	3	71	1	0	0	0	0	1	0	0	0	270	159	6	5	100	5	ADAMTS6	5	64447760	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	9024914	64447760	116467500	51	22020										
POLK	51426	broad.mit.edu	37	chr5	74880637	74880637	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gttaaaggcccttggaattaTtacatgtacagaactttacc	7	8	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:74880637T>C	uc003kdw.2	+	9	1208	c.1112T>C	c.(1111-1113)ATT>ACT	p.I371T	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003keb.2_Missense_Mutation_p.I371T|POLK_uc010izq.2_Intron|POLK_uc003kec.2_Missense_Mutation_p.I281T|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.I281T|POLK_uc003kee.2_Missense_Mutation_p.I371T|POLK_uc003kef.2_Missense_Mutation_p.I281T	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	371					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		CTTGGAATTATTACATGTACA	0.333								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.062417	0	23	33										C	74880637	T	C	74880637	3	2	71	1	0	0	0	0	1	0	0	0	12204	1493	52	5	1142	5	POLK	5	74880637	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	10432877	74880637	106034623	52	22021										
MCTP1	79772	broad.mit.edu	37	chr5	94207113	94207113	+	Frame_Shift_Del	DEL	T	T	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tcaagaactgaatggatatcTttaatgttgctgcataataa							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:94207113delT	uc003kkx.2	-	14	2046	c.2046delA	c.(2044-2046)AAAfs	p.K682fs	MCTP1_uc003kkv.2_Frame_Shift_Del_p.K461fs|MCTP1_uc003kkw.2_Frame_Shift_Del_p.K415fs|MCTP1_uc003kkz.2_Frame_Shift_Del_p.K343fs|MCTP1_uc003kku.2_Frame_Shift_Del_p.K198fs	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	682	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AATGGATATCTTTAATGTTGC	0.338																		25	36	---	---								-	94207113	T	-	94207113	7	5	71	1	0	1	0	1	0	0	0	0	9400	1606	56	0	993	0	MCTP1	5	94207113	Frame_Shift_Del	DEL	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	19326476	94207113	86708147	53	22022										
CHD1	1105	broad.mit.edu	37	chr5	98232075	98232075	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	attgatgttcatgaaacaaaTaattcagaaatgagatcgtc	7	5	2	4			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:98232075T>C	uc003knf.2	-	11	1713	c.1565A>G	c.(1564-1566)TAT>TGT	p.Y522C		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	522	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATGAAACAAATAATTCAGAAA	0.363													0	0	0	0.021553	0	6	75										C	98232075	T	C	98232075	3	2	71	1	0	0	0	0	1	0	0	0	3323	1406	49	5	3667	5	CHD1	5	98232075	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	4024962	98232075	82683185	54	22023										
MEGF10	84466	broad.mit.edu	37	chr5	126732390	126732390	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tatggtaacgactgtcatcaGagatgccagtgccagaatgg	12	8	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:126732390G>A	uc003kuh.3	+	7	941	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	MEGF10_uc010jdc.1_Silent_p.Q193Q|MEGF10_uc010jdd.1_Silent_p.Q193Q|MEGF10_uc003kui.3_Silent_p.Q193Q	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	193	Extracellular (Potential).|EGF-like 3.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACTGTCATCAGAGATGCCAGT	0.642													0	0	0	0.048971	0	56	80										A	126732390	G	A	126732390	2	1	71	1	0	0	0	0	0	0	0	1	9460	933	33	1		1	MEGF10	5	126732390	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	28500315	126732390	54182870	55	22024										
FNIP1	96459	broad.mit.edu	37	chr5	131006321	131006321	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcactcacttcgattaacttTgacctggaagaaaaatgccc	7	11	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:131006321T>C	uc003kvs.1	-	15	3085	c.2943A>G	c.(2941-2943)TCA>TCG	p.S981S	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Silent_p.S953S	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	981					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		CGATTAACTTTGACCTGGAAG	0.373													0	0	0	0.033182	0	43	60										C	131006321	T	C	131006321	2	2	71	1	0	0	0	0	0	0	0	1	5975	1799	63	5		5	FNIP1	5	131006321	Silent	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	4273931	131006321	49908939	56	22025										
PCDHA2	56146	broad.mit.edu	37	chr5	140175218	140175218	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gggggcaaacctgagctcacGggcaccgttcaaatacttat	11	11	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140175218G>A	uc003lhd.2	+	1	775	c.669G>A	c.(667-669)ACG>ACA	p.T223T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.T223T|PCDHA2_uc011czy.1_Silent_p.T223T	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	223	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAGCTCACGGGCACCGTTC	0.418													0	0	0	0.048971	0	64	72										A	140175218	G	A	140175218	2	1	71	1	0	0	0	0	0	0	0	1	11524	1103	39	2		2	PCDHA2	5	140175218	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	9168897	140175218	40740042	57	22026										
PCDHA8	56140	broad.mit.edu	37	chr5	140221088	140221088	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggagctggcggagctggtgcCgcgcctgttccgggtggcgt	20	11	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140221088C>A	uc003lhs.2	+	1	182	c.182C>A	c.(181-183)CCG>CAG	p.P61Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.P61Q	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	61	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGGTGCCGCGCCTGTTC	0.637													1	0	6.00419e-47	0.048971	6.97784e-47	100	149										A	140221088	C	A	140221088	3	1	71	1	0	0	0	0	1	0	0	0	11530	652	23	4	184	4	PCDHA8	5	140221088	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	45870	140221088	40694172	58	22027										
PCDHGA3	56112	broad.mit.edu	37	chr5	140725934	140725934	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cagcccaactatgcggacacGctcatcagccaggagagctg	11	14	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140725934G>A	uc003ljm.1	+	1	2334	c.2334G>A	c.(2332-2334)ACG>ACA	p.T778T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.T538T|PCDHGA3_uc011dap.1_Silent_p.T778T	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	778	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCGGACACGCTCATCAGCC	0.522													0	0	0	0.016723	0	14	207										A	140725934	G	A	140725934	2	1	71	1	0	0	0	0	0	0	0	1	11555	1074	38	2		2	PCDHGA3	5	140725934	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	504846	140725934	40189326	59	22028										
PCDHGB2	56103	broad.mit.edu	37	chr5	140740651	140740651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agattgcaagtagttacactCtgagtatcgaagcaaaagat	9	6	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140740651C>G	uc003ljs.1	+	1	949	c.949C>G	c.(949-951)CTG>GTG	p.L317V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.L317V	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	317	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGTTACACTCTGAGTATCGA	0.388													0	0	0	0.009096	0	4	35										G	140740651	C	G	140740651	3	3	71	1	0	0	0	0	1	0	0	0	11563	912	32	1	951	1	PCDHGB2	5	140740651	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	14717	140740651	40174609	60	22029										
SPRY4	81848	broad.mit.edu	37	chr5	141694316	141694316	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tggtgaggcctggtcagccaCgggtggtggtgccatgtggt	19	8	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:141694316C>A	uc003lml.2	-	2	617	c.358G>T	c.(358-360)GTG>TTG	p.V120L	SPRY4_uc010jgi.1_Missense_Mutation_p.V143L	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	120					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCAGCCACGGGTGGTGGT	0.662									Testicular_Cancer_Familial_Clustering_of				1	0	2.73381e-35	0.048971	3.12643e-35	57	94										A	141694316	C	A	141694316	3	1	71	1	0	0	0	0	1	0	0	0	15107	536	19	4	545	4	SPRY4	5	141694316	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	953665	141694316	39220944	61	22030										
RBM22	55696	broad.mit.edu	37	chr5	150075243	150075243	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	attctgatcagcaagggggtCatctggatctgtaggcttct	12	8	6	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:150075243C>T	uc003lst.2	-	7	693	c.571G>A	c.(571-573)GAC>AAC	p.D191N		NM_018047	NP_060517	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	191					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding				0		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAAGGGGGTCATCTGGATCT	0.413													0	0	0	0.058154	0	8	52										T	150075243	C	T	150075243	3	4	71	1	0	0	0	0	1	0	0	0	13122	826	29	1	711	1	RBM22	5	150075243	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	8380927	150075243	30840017	62	22031										
SLU7	10569	broad.mit.edu	37	chr5	159835026	159835026	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aaggattctctctcattgctCtagtttttggatcatagtag	8	7	4	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:159835026C>A	uc003lyg.2	-	9	1024	c.869G>T	c.(868-870)AGA>ATA	p.R290I		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	290					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTCATTGCTCTAGTTTTTGG	0.299													1	0	1.61863e-15	0.048971	1.73137e-15	45	75										A	159835026	C	A	159835026	3	1	71	1	0	0	0	0	1	0	0	0	14755	913	32	3	923	3	SLU7	5	159835026	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	9759783	159835026	21080234	63	22032										
SLIT3	6586	broad.mit.edu	37	chr5	168244341	168244341	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cttcttctgcacatccgccaCgttgaagcccctcaaatgca	6	16	3	1	rs143627388		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:168244341C>T	uc003mab.2	-	8	1177	c.757G>A	c.(757-759)GTG>ATG	p.V253M	SLIT3_uc010jjg.2_Missense_Mutation_p.V253M|SLIT3_uc010jji.2_Missense_Mutation_p.V253M|SLIT3_uc003mac.1_Missense_Mutation_p.V50M	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	253	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATCCGCCACGTTGAAGCCC	0.597													0	0	0	0.038147	0	8	91										T	168244341	C	T	168244341	3	4	71	1	0	0	0	0	1	0	0	0	14741	536	19	2	3930	2	SLIT3	5	168244341	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	8409315	168244341	12670919	64	22033										
NEDD9	4739	broad.mit.edu	37	chr6	11190347	11190347	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ccaggatgcagcagctgtccCtgggagccaccgtgtgggta	15	12	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:11190347C>T	uc003mzv.2	-	5	1922	c.1755G>A	c.(1753-1755)CAG>CAA	p.Q585Q	NEDD9_uc010joz.2_Silent_p.Q585Q|NEDD9_uc003mzw.3_Silent_p.Q439Q	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	585					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCAGCTGTCCCTGGGAGCCAC	0.632													0	0	0	0.045705	0	32	65										T	11190347	C	T	11190347	2	4	71	1	0	0	0	0	0	0	0	1	10313	680	24	2		2	NEDD9	6	11190347	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		11190347	159924720	65	22034										
FAM65B	9750	broad.mit.edu	37	chr6	24850033	24850033	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aaggaagaggcacttactacCaggtgatttccaggttcagt	11	8	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:24850033C>T	uc003neo.1	-	11	1120	c.944G>A	c.(943-945)TGG>TAG	p.W315*	FAM65B_uc011djs.1_Nonsense_Mutation_p.W344*|FAM65B_uc011dju.1_Nonsense_Mutation_p.W349*|FAM65B_uc003nep.2_Nonsense_Mutation_p.W315*|FAM65B_uc011djt.1_Nonsense_Mutation_p.W315*	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	315					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						CACTTACTACCAGGTGATTTC	0.358													0	0	0	0.024334	0	27	374										T	24850033	C	T	24850033	4	4	71	1	0	0	0	0	0	1	0	0	5600	595	21	2	2324	2	FAM65B	6	24850033	Nonsense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	13659686	24850033	146265034	66	22035										
HIST1H1C	3006	broad.mit.edu	37	chr6	26056507	26056507	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	actccgctacgctctttagaGgcggccacagccttggtgat	11	13	1	2	rs150897775		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:26056507G>A	uc003nfw.2	-	1	193	c.150C>T	c.(148-150)GCC>GCT	p.A50A		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	50	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GCTCTTTAGAGGCGGCCACAG	0.567													0	0	0	0.048971	0	55	89										A	26056507	G	A	26056507	2	1	71	1	0	0	0	0	0	0	0	1	7124	987	35	2		2	HIST1H1C	6	26056507	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1206474	26056507	145058560	67	22036										
ABT1	29777	broad.mit.edu	37	chr6	26598817	26598817	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggctcctggccaggatctttGgagccccgccaccctcagag	12	16	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:26598817G>A	uc003nii.2	+	3	794	c.763G>A	c.(763-765)GGA>AGA	p.G255R		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	255					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						CAGGATCTTTGGAGCCCCGCC	0.662													0	0	0	0.024334	0	26	41										A	26598817	G	A	26598817	3	1	71	1	0	0	0	0	1	0	0	0	101	1349	47	2	773	2	ABT1	6	26598817	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	542310	26598817	144516250	68	22037										
GABBR1	2550	broad.mit.edu	37	chr6	29589570	29589570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttcagtctcatagaaaagtcCcacgatgattcgggcatcct	8	11	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:29589570C>T	uc003nmt.3	-	10	1426	c.1090G>A	c.(1090-1092)GGA>AGA	p.G364R	GABBR1_uc003nmp.3_Missense_Mutation_p.G247R|GABBR1_uc003nms.3_Missense_Mutation_p.G247R|GABBR1_uc003nmu.3_Missense_Mutation_p.G302R|GABBR1_uc011dlr.1_Missense_Mutation_p.G187R|GABBR1_uc011dls.1_Missense_Mutation_p.G364R	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	364	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.G364G(1)		ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	TAGAAAAGTCCCACGATGATT	0.527													0	0	0	0.048971	0	43	54										T	29589570	C	T	29589570	3	4	71	1	0	0	0	0	1	0	0	0	6155	632	22	2	1851	2	GABBR1	6	29589570	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	2990753	29589570	141525497	69	22038										
PSORS1C1	170679	broad.mit.edu	37	chr6	31107475	31107475	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttccatctggcagccacccaGgatgactgcagaaaaggaag	11	11	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:31107475G>A	uc003nsl.1	+	6	499	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	PSORS1C1_uc010jsj.1_Silent_p.Q24Q|PSORS1C1_uc003nsn.1_RNA|PSORS1C2_uc003nso.3_5'Flank	NM_014068	NP_054787	Q9UIG5	PS1C1_HUMAN	SEEK1 protein	75										ovary(1)	1						CAGCCACCCAGGATGACTGCA	0.547													0	0	0	0.045705	0	34	33										A	31107475	G	A	31107475	2	1	71	1	0	0	0	0	0	0	0	1	12714	991	35	2		2	PSORS1C1	6	31107475	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1517905	31107475	140007592	70	22039										
DDAH2	23564	broad.mit.edu	37	chr6	31696843	31696843	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gccagatccagagcgggaagGccagcccccgcaccttcccc	11	19	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:31696843G>A	uc003nwp.2	-	1	727	c.96C>T	c.(94-96)GGC>GGT	p.G32G	DDAH2_uc003nwq.2_Silent_p.G32G	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	32					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	GAGCGGGAAGGCCAGCCCCCG	0.677													0	0	0	0.048971	0	57	75										A	31696843	G	A	31696843	2	1	71	1	0	0	0	0	0	0	0	1	4322	1190	42	2		2	DDAH2	6	31696843	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	589368	31696843	139418224	71	22040										
VARS	7407	broad.mit.edu	37	chr6	31750569	31750569	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gatggcctccagcccgtgccGctgcccaacttcatagtcat	9	16	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:31750569G>A	uc003nxe.2	-	15	2239	c.1816C>T	c.(1816-1818)CGG>TGG	p.R606W	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_Intron	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	606					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	AGCCCGTGCCGCTGCCCAACT	0.607													0	0	0	0.014758	0	5	73										A	31750569	G	A	31750569	3	1	71	1	0	0	0	0	1	0	0	0	17120	1086	38	2	2042	2	VARS	6	31750569	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	53726	31750569	139364498	72	22041										
DNAH8	1769	broad.mit.edu	37	chr6	38810224	38810224	+	Frame_Shift_Del	DEL	T	T	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tagtggttattatgaaatacTttggggagatgtagatattg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:38810224delT	uc003ooe.1	+	32	4496	c.3896delT	c.(3895-3897)CTTfs	p.L1299fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TATGAAATACTTTGGGGAGAT	0.343																		30	72	---	---								-	38810224	T	-	38810224	7	5	71	1	0	1	0	1	0	0	0	0	4607	1609	56	0	4014	0	DNAH8	6	38810224	Frame_Shift_Del	DEL	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	7059655	38810224	132304843	73	22042										
TRERF1	55809	broad.mit.edu	37	chr6	42236492	42236492	+	Frame_Shift_Del	DEL	C	C	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgcatggagatacgctgttgCccggcttgctgctgttgctg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:42236492delC	uc003osd.2	-	5	1400	c.837delG	c.(835-837)GGGfs	p.G279fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.G279fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.G118fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.G118fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.G279fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	279	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TACGCTGTTGCCCGGCTTGCT	0.512																		64	118	---	---								-	42236492	C	-	42236492	7	5	71	1	0	1	0	1	0	0	0	0	16472	726	26	0	2821	0	TRERF1	6	42236492	Frame_Shift_Del	DEL	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	3426268	42236492	128878575	74	22043										
DST	667	broad.mit.edu	37	chr6	56479254	56479254	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	attctttggctttttcaacaTgttctttcttttcttcttcc	3	10	6	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:56479254T>G	uc003pdf.2	-	36	4887	c.4859A>C	c.(4858-4860)CAT>CCT	p.H1620P	DST_uc003pcz.3_Missense_Mutation_p.H1442P|DST_uc011dxj.1_Missense_Mutation_p.H1471P|DST_uc011dxk.1_Missense_Mutation_p.H1482P|DST_uc003pcy.3_Missense_Mutation_p.H1116P|DST_uc003pdb.2_Missense_Mutation_p.H1116P	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.G1620D(1)		ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTTTCAACATGTTCTTTCTT	0.368													0	0	0	0.02938	0	7	15										G	56479254	T	G	56479254	3	3	71	1	0	0	0	0	1	0	0	0	4783	1464	51	5	12416	5	DST	6	56479254	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	14242762	56479254	114635813	75	22044										
KHDRBS2	202559	broad.mit.edu	37	chr6	62442653	62442653	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggtcatcatattcacccccgTagccatcatcataaccctga	5	15	5	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:62442653T>C	uc003peg.2	-	7	1074	c.827A>G	c.(826-828)TAC>TGC	p.Y276C		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTCACCCCCGTAGCCATCATC	0.383													0	0	0	0.030593	0	26	43										C	62442653	T	C	62442653	3	2	71	1	0	0	0	0	1	0	0	0	8147	1638	57	5	234	5	KHDRBS2	6	62442653	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	5963399	62442653	108672414	76	22045										
CD109	135228	broad.mit.edu	37	chr6	74473393	74473393	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	actgtcttgaagccatctctCaacttcacagccactgtaag	6	13	4	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:74473393C>G	uc003php.2	+	10	1517	c.1092C>G	c.(1090-1092)CTC>CTG	p.L364L	CD109_uc010kaz.2_Silent_p.L364L|CD109_uc003phq.2_Silent_p.L364L|CD109_uc010kba.2_Silent_p.L287L	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	364						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						AGCCATCTCTCAACTTCACAG	0.318													0	0	0	0.049695	0	20	35										G	74473393	C	G	74473393	2	3	71	1	0	0	0	0	0	0	0	1	2963	813	29	1		1	CD109	6	74473393	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	12030740	74473393	96641674	77	22046										
ORC3L	23595	broad.mit.edu	37	chr6	88376826	88376826	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gaccatgtggcaagactaacAtggggaggctgctagaaagc	14	8	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:88376826A>T	uc003pmh.2	+	20	2165	c.2121A>T	c.(2119-2121)ACA>ACT	p.T707T	ORC3L_uc003pmg.2_Silent_p.T708T|ORC3L_uc003pmi.2_Silent_p.T670T|ORC3L_uc011dzo.1_Silent_p.T564T|ORC3L_uc011dzp.1_Silent_p.T564T|ORC3L_uc003pmj.1_RNA	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	707					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		CAAGACTAACATGGGGAGGCT	0.393													0	0	0	0.062417	0	21	30										T	88376826	A	T	88376826	2	4	71	1	0	0	0	0	0	0	0	1	11263	204	8	5		5	ORC3L	6	88376826	Silent	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	13903433	88376826	82738241	78	22047										
REV3L	5980	broad.mit.edu	37	chr6	111636553	111636553	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	accaatcttaaaagactgctCcttagtggctcctttcagta	6	11	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:111636553C>G	uc003puy.3	-	27	8706	c.8383G>C	c.(8383-8385)GAG>CAG	p.E2795Q	REV3L_uc003pux.3_Missense_Mutation_p.E2717Q|REV3L_uc003puz.3_Missense_Mutation_p.E2717Q|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2795					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAAGACTGCTCCTTAGTGGCT	0.343								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.016723	0	14	23										G	111636553	C	G	111636553	3	3	71	1	0	0	0	0	1	0	0	0	13240	864	30	1	1033	1	REV3L	6	111636553	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	23259727	111636553	59478514	79	22048										
UTRN	7402	broad.mit.edu	37	chr6	144863938	144863938	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cctgatgcggtagatttgcaGagaggtgcctaccaccctga	12	11	0	4			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:144863938G>A	uc003qkt.2	+	45	6619	c.6527G>A	c.(6526-6528)AGA>AAA	p.R2176K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2176					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TAGATTTGCAGAGAGGTGCCT	0.393													0	0	0	0.016723	0	11	13										A	144863938	G	A	144863938	3	1	71	1	0	0	0	0	1	0	0	0	17100	942	33	1	6705	1	UTRN	6	144863938	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	33227385	144863938	26251129	80	22049										
SNX13	23161	broad.mit.edu	37	chr7	17843094	17843094	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atctttctgacattttgcccAtgttgtctgacattttagtc	6	9	3	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:17843094A>G	uc003stw.1	-	21	2420	c.2207T>C	c.(2206-2208)ATG>ACG	p.M736T	SNX13_uc003stv.2_Missense_Mutation_p.M725T|SNX13_uc010kuc.2_Missense_Mutation_p.M522T|SNX13_uc010kub.2_Missense_Mutation_p.M131T			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	736					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					CATTTTGCCCATGTTGTCTGA	0.338													0	0	0	0.020292	0	14	16										G	17843094	A	G	17843094	3	3	71	1	0	0	0	0	1	0	0	0	14884	217	8	5	723	5	SNX13	7	17843094	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08		17843094	141295569	81	22050										
DNAH11	8701	broad.mit.edu	37	chr7	21721207	21721207	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tacacttttgctgggagaacTtccacctggagacagacaga	10	10	0	4			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:21721207T>C	uc003svc.2	+	31	5418	c.5387T>C	c.(5386-5388)CTT>CCT	p.L1796P		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1796	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTGGGAGAACTTCCACCTGGA	0.388									Kartagener_syndrome				0	0	0	0.043863	0	19	39										C	21721207	T	C	21721207	3	2	71	1	0	0	0	0	1	0	0	0	4599	1609	56	5	5509	5	DNAH11	7	21721207	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	3878113	21721207	137417456	82	22051										
ZAN	7455	broad.mit.edu	37	chr7	100365467	100365467	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tctgcagctgaatggccatcGggtggccctacctgtgtggc	14	12	1	1	rs74848966	by1000genomes	TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:100365467G>A	uc003uwj.2	+	26	5039	c.4874G>A	c.(4873-4875)CGG>CAG	p.R1625Q	ZAN_uc003uwk.2_Missense_Mutation_p.R1625Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.R202Q	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1625	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AATGGCCATCGGGTGGCCCTA	0.498													0	0	0	0.0333	0	18	33										A	100365467	G	A	100365467	3	1	71	1	0	0	0	0	1	0	0	0	17510	1116	39	2	4972	2	ZAN	7	100365467	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	78644260	100365467	58773196	83	22052										
PIK3CG	5294	broad.mit.edu	37	chr7	106509636	106509636	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acccggaaggggaccgggttCgagcagaaatgcccaaccag	14	12	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:106509636C>T	uc003vdv.3	+	2	1715	c.1630C>T	c.(1630-1632)CGA>TGA	p.R544*	PIK3CG_uc003vdu.2_Nonsense_Mutation_p.R544*|PIK3CG_uc003vdw.2_Nonsense_Mutation_p.R544*	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	544					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GGACCGGGTTCGAGCAGAAAT	0.542													0	0	0	0.039052	0	43	66										T	106509636	C	T	106509636	4	4	71	1	0	0	0	0	0	1	0	0	11916	876	31	1	1632	1	PIK3CG	7	106509636	Nonsense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	6144169	106509636	52629027	84	22053										
PLXNA4	91584	broad.mit.edu	37	chr7	131865461	131865461	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gtagttcagcttcacgttgcCcccagccacaggcgggatca	11	14	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:131865461C>T	uc003vra.3	-	19	3752	c.3523G>A	c.(3523-3525)GGC>AGC	p.G1175S		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1175	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TTCACGTTGCCCCCAGCCACA	0.597													0	0	0	0.014758	0	4	62										T	131865461	C	T	131865461	3	4	71	1	0	0	0	0	1	0	0	0	12122	623	22	2	2217	2	PLXNA4	7	131865461	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	25355825	131865461	27273202	85	22054										
HIPK2	28996	broad.mit.edu	37	chr7	139416296	139416296	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cagctgatagtcgccctcgcTgttggagccgctgtttttgg	13	11	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:139416296T>A	uc003vvf.3	-	2	712	c.538A>T	c.(538-540)AGC>TGC	p.S180C	HIPK2_uc003vvd.3_Missense_Mutation_p.S180C	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	180	Transcriptional corepression (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					TCGCCCTCGCTGTTGGAGCCG	0.572													0	0	0	0.048971	0	66	83										A	139416296	T	A	139416296	3	1	71	1	0	0	0	0	1	0	0	0	7117	1580	55	5	3114	5	HIPK2	7	139416296	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	7550835	139416296	19722367	86	22055										
SLC4A2	6522	broad.mit.edu	37	chr7	150761698	150761698	+	Frame_Shift_Del	DEL	C	C	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cgccgcaagacaccccagggCccaggacggaagcctcgaag							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:150761698delC	uc003wit.3	+	4	559	c.303delC	c.(301-303)GGCfs	p.G101fs	SLC4A2_uc011kve.1_Frame_Shift_Del_p.G92fs|SLC4A2_uc003wiu.3_Frame_Shift_Del_p.G87fs	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	101	Cytoplasmic (Potential).|Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCCCAGGGCCCAGGACGGA	0.682																		55	75	---	---								-	150761698	C	-	150761698	7	5	71	1	0	1	0	1	0	0	0	0	14654	726	26	0	313	0	SLC4A2	7	150761698	Frame_Shift_Del	DEL	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	11345402	150761698	8376965	87	22056										
MLL3	58508	broad.mit.edu	37	chr7	151877847	151877847	+	Frame_Shift_Del	DEL	A	A	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atatttacagtattctgtgtAtcagttactcctgaagttgg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:151877847delA	uc003wla.2	-	36	7317	c.7098delT	c.(7096-7098)GATfs	p.D2366fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.D1427fs|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2366					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TATTCTGTGTATCAGTTACTC	0.428			N		medulloblastoma													40	28	---	---								-	151877847	A	-	151877847	7	5	71	1	0	1	0	1	0	0	0	0	9622	446	16	0	7733	0	MLL3	7	151877847	Frame_Shift_Del	DEL	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	1116149	151877847	7260816	88	22057										
ESYT2	57488	broad.mit.edu	37	chr7	158528300	158528300	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acgaaacactgaaatcaaagCtgaaataggaaacgagagcc	9	8	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:158528300C>T	uc003wob.1	-	20	2547	c.2481_splice	c.e20-1	p.S827_splice	ESYT2_uc003wny.1_Splice_Site|ESYT2_uc003wnz.1_Splice_Site_p.S266_splice|ESYT2_uc003woa.1_Splice_Site_p.S404_splice	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain							integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						GAAATCAAAGCTGAAATAGGA	0.428													0	0	0	0.048971	0	66	83										T	158528300	C	T	158528300	5	4	71	1	0	0	0	0	0	0	1	0	5265	811	28	2	213	2	ESYT2	7	158528300	Splice_Site	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	6650453	158528300	610363	89	22058										
PINX1	54984	broad.mit.edu	37	chr8	10623339	10623339	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gggcttgttcttcagtgctgCcatccgcttggcaaagtact	11	11	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:10623339C>T	uc003wth.2	-	7	592	c.559G>A	c.(559-561)GCA>ACA	p.A187T	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_Missense_Mutation_p.G161D	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	187					mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)		TTCAGTGCTGCCATCCGCTTG	0.547													0	0	0	0.048971	0	162	171										T	10623339	C	T	10623339	3	4	71	1	0	0	0	0	1	0	0	0	11933	739	26	2	431	2	PINX1	8	10623339	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		10623339	135740683	90	22059										
CNBD1	168975	broad.mit.edu	37	chr8	87951882	87951882	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aacctgatgattctaacaatAtagctgtccatgttcagaga	7	8	2	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:87951882A>T	uc003ydy.2	+	4	379	c.331A>T	c.(331-333)ATA>TTA	p.I111L		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	111										ovary(3)	3						TTCTAACAATATAGCTGTCCA	0.348													0	0	0	0.064281	0	33	58										T	87951882	A	T	87951882	3	4	71	1	0	0	0	0	1	0	0	0	3591	449	16	5	345	5	CNBD1	8	87951882	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	77328543	87951882	58412140	91	22060										
FER1L6	654463	broad.mit.edu	37	chr8	125113410	125113410	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tccctgactggagagggcaaCttcaactggcgcttcctgtt	11	12	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:125113410C>A	uc003yqw.2	+	38	5162	c.4956C>A	c.(4954-4956)AAC>AAA	p.N1652K	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1652	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAGAGGGCAACTTCAACTGGC	0.433													1	0	3.73808e-20	0.027356	4.07963e-20	29	50										A	125113410	C	A	125113410	3	1	71	1	0	0	0	0	1	0	0	0	5815	564	20	4	5102	4	FER1L6	8	125113410	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	37161528	125113410	21250612	92	22061										
COL22A1	169044	broad.mit.edu	37	chr8	139606409	139606409	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gagatgacttcatgtacgccGggggcatctgggccaggagg	17	9	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:139606409G>A	uc003yvd.2	-	63	4913	c.4466C>T	c.(4465-4467)CCG>CTG	p.P1489L	COL22A1_uc011ljo.1_Missense_Mutation_p.P769L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1489	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CATGTACGCCGGGGGCATCTG	0.592										HNSCC(7;0.00092)			0	0	0	0.048971	0	44	52										A	139606409	G	A	139606409	3	1	71	1	0	0	0	0	1	0	0	0	3681	1116	39	2	426	2	COL22A1	8	139606409	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	14492999	139606409	6757613	93	22062										
DENND3	22898	broad.mit.edu	37	chr8	142151356	142151356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gggagtgtcctggctgcttcGtgcccttcgcggtgtgcgtg	17	11	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:142151356G>A	uc003yvy.2	+	4	594	c.316G>A	c.(316-318)GTG>ATG	p.V106M	DENND3_uc003yvw.1_Missense_Mutation_p.V119M|DENND3_uc003yvx.2_Silent_p.S184S|DENND3_uc010mep.2_Missense_Mutation_p.V119M	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	106	DENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCTGCTTCGTGCCCTTCGC	0.577													0	0	0	0.020292	0	14	144										A	142151356	G	A	142151356	3	1	71	1	0	0	0	0	1	0	0	0	4432	1145	40	2	326	2	DENND3	8	142151356	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	2544947	142151356	4212666	94	22063										
TSNARE1	203062	broad.mit.edu	37	chr8	143399942	143399942	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcagctcggccatctgcttcAcggagctggcgctggctgca	14	14	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:143399942A>G	uc003ywk.2	-	7	1065	c.947T>C	c.(946-948)GTG>GCG	p.V316A	TSNARE1_uc011lju.1_Missense_Mutation_p.V316A|TSNARE1_uc003ywj.2_Missense_Mutation_p.V316A|TSNARE1_uc003ywl.3_Missense_Mutation_p.V97A	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	316					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CATCTGCTTCACGGAGCTGGC	0.662													0	0	0	0.048971	0	62	125										G	143399942	A	G	143399942	3	3	71	1	0	0	0	0	1	0	0	0	16627	159	6	5	622	5	TSNARE1	8	143399942	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	1248586	143399942	2964080	95	22064										
BAI1	575	broad.mit.edu	37	chr8	143599522	143599522	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atggagaaggcgactctgccGtcggtgacgctcatcgtggg	16	10	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:143599522G>A	uc003ywm.2	+	18	3024	c.2841G>A	c.(2839-2841)CCG>CCA	p.P947P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	947	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGACTCTGCCGTCGGTGACGC	0.647													0	0	0	0.030466	0	38	65										A	143599522	G	A	143599522	2	1	71	1	0	0	0	0	0	0	0	1	1298	1132	40	2		2	BAI1	8	143599522	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	199580	143599522	2764500	96	22065										
C8orf73	642475	broad.mit.edu	37	chr8	144650796	144650796	+	Frame_Shift_Del	DEL	G	G	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctgcagcaccagcttccgcaGggggccgcggagccccagcc							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:144650796delG	uc010mff.2	-	10	1614	c.1570delC	c.(1570-1572)CTGfs	p.L524fs	C8orf73_uc010mfg.1_Frame_Shift_Del_p.P536fs	NM_001100878	NP_001094348	A6NGR9	CH073_HUMAN	hypothetical protein LOC642475	524	Leu-rich.						binding			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGCTTCCGCAgggggccgcgg	0.532																		2	4	---	---								-	144650796	G	-	144650796	7	5	71	1	0	1	0	1	0	0	0	0	2435	991	35	0	609	0	C8orf73	8	144650796	Frame_Shift_Del	DEL	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1051274	144650796	1713226	97	22066										
FBP1	2203	broad.mit.edu	37	chr9	97365704	97365704	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atacaccttcaggaactcgaGcacgtcgtcgggggatccca	11	13	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:97365704G>T	uc004auw.3	-	7	1307	c.976C>A	c.(976-978)CTC>ATC	p.L326I	FBP1_uc010mrl.2_Missense_Mutation_p.L326I	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	326					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	AGGAACTCGAGCACGTCGTCG	0.587											OREG0019330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	4.96729e-08	0.049695	5.18431e-08	18	20										T	97365704	G	T	97365704	3	4	71	1	0	0	0	0	1	0	0	0	5705	971	34	4	44	4	FBP1	9	97365704	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		97365704	43847727	98	22067										
PTCH1	5727	broad.mit.edu	37	chr9	98240410	98240410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tcaggatgtcgtccagggtcGtggtggtgaaggaaagcacc	16	8	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:98240410G>A	uc004avk.3	-	9	1462	c.1274C>T	c.(1273-1275)ACG>ATG	p.T425M	PTCH1_uc010mro.2_Missense_Mutation_p.T274M|PTCH1_uc010mrp.2_Missense_Mutation_p.T274M|PTCH1_uc010mrq.2_Missense_Mutation_p.T274M|PTCH1_uc004avl.3_Missense_Mutation_p.T274M|PTCH1_uc010mrr.2_Missense_Mutation_p.T359M|PTCH1_uc004avm.3_Missense_Mutation_p.T424M|PTCH1_uc010mrs.1_Missense_Mutation_p.T145M	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	425	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GTCCAGGGTCGTGGTGGTGAA	0.532									Basal_Cell_Nevus_syndrome				0	0	0	0.01892	0	26	68										A	98240410	G	A	98240410	3	1	71	1	0	0	0	0	1	0	0	0	12730	1145	40	2	3129	2	PTCH1	9	98240410	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	874706	98240410	42973021	99	22068										
PAPPA	5069	broad.mit.edu	37	chr9	119065048	119065048	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttttgcagatgaacccagccGgtgctatttccatgatggtg	11	9	0	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:119065048G>A	uc004bjn.2	+	10	3347	c.2966G>A	c.(2965-2967)CGG>CAG	p.R989Q	PAPPA_uc011lxp.1_Missense_Mutation_p.R684Q|PAPPA_uc011lxq.1_Missense_Mutation_p.R364Q	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	989					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GAACCCAGCCGGTGCTATTTC	0.453													0	0	0	0.043863	0	18	45										A	119065048	G	A	119065048	3	1	71	1	0	0	0	0	1	0	0	0	11432	1116	39	2	3004	2	PAPPA	9	119065048	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	20824638	119065048	22148383	100	22069										
SH2D3C	10044	broad.mit.edu	37	chr9	130536733	130536733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gagagactcccaaagcccttGaacttgaagaactctagcag	9	11	1	4			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:130536733G>C	uc004bsc.2	-	2	193	c.51C>G	c.(49-51)TTC>TTG	p.F17L	SH2D3C_uc004bsd.1_5'UTR	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	17					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CAAAGCCCTTGAACTTGAAGA	0.473													0	0	0	0.014758	0	5	48										C	130536733	G	C	130536733	3	2	71	1	0	0	0	0	1	0	0	0	14234	1281	45	1	2708	1	SH2D3C	9	130536733	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	11471685	130536733	10676698	101	22070										
NOTCH1	4851	broad.mit.edu	37	chr9	139395013	139395025	+	Frame_Shift_Del	DEL	ACCTTGTGCGTCG	ACCTTGTGCGTCG	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ccactgcctacctggaagacAccttgtgcgtcggcagacac							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:139395013_139395025delACCTTGTGCGTCG	uc004chz.2	-	31	5913_5925	c.5913_5925delCGACGCACAAGGT	c.(5911-5925)GCCGACGCACAAGGTfs	p.A1971fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1971_1975	ANK 2.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCTGGAAGACACCTTGTGCGTCGGCAGACACAG	0.676			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)								36	120	---	---								-	139395025	ACCTTGTGCGTCG	-	139395013	7	5	71	1	0	1	0	1	0	0	0	0	10547	146	6	0	1758	0	NOTCH1	9	139395013	Frame_Shift_Del	DEL	ACCTTGTGCGTCG	TCGA-E7-A3Y1-01A-11D-A22Z-08	8858280	139395013	1818418	102	22071										
NOTCH1	4851	broad.mit.edu	37	chr9	139399556	139399556	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cagtactggtcgtacaggggGctgtggggggcgggacacgc	20	9	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:139399556G>A	uc004chz.2	-	26	4587	c.4587C>T	c.(4585-4587)AAC>AAT	p.N1529N	NOTCH1_uc004cia.1_Silent_p.N759N	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1529	Extracellular (Potential).|LNR 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTACAGGGGGCTGTGGGGGG	0.731			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.038395	0	16	18										A	139399556	G	A	139399556	2	1	71	1	0	0	0	0	0	0	0	1	10547	1217	42	2		2	NOTCH1	9	139399556	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	4543	139399556	1813875	103	22072										
IDI2	91734	broad.mit.edu	37	chr10	1066766	1066766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctgggctgccctcctcactcCgatggcatccttttcttcca	7	17	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:1066766C>T	uc001ifv.1	-	4	372	c.307G>A	c.(307-309)GGA>AGA	p.G103R	C10orf110_uc010qaf.1_5'Flank|C10orf110_uc001ifx.3_5'Flank|C10orf110_uc001ifw.3_5'Flank|C10orf110_uc001ify.3_5'Flank	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	103	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		CTCCTCACTCCGATGGCATCC	0.542													0	0	0	0.014323	0	22	29										T	1066766	C	T	1066766	3	4	71	1	0	0	0	0	1	0	0	0	7500	661	23	2	384	2	IDI2	10	1066766	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		1066766	134467981	104	22073										
CUBN	8029	broad.mit.edu	37	chr10	16994309	16994309	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgaatgatccagctgcagttCtgattgtttggataattggc	11	6	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:16994309C>T	uc001ioo.2	-	33	4987	c.4935G>A	c.(4933-4935)CAG>CAA	p.Q1645Q		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1645	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCTGCAGTTCTGATTGTTTG	0.478													0	0	0	0.048971	0	49	65										T	16994309	C	T	16994309	2	4	71	1	0	0	0	0	0	0	0	1	4051	912	32	1		1	CUBN	10	16994309	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	15927543	16994309	118540438	105	22074										
MPP7	143098	broad.mit.edu	37	chr10	28358781	28358782	+	Splice_Site	DNP	CC	CC	AA													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tcagccctactcccacgggaCctgaaaaacagggtaacaga							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:28358781_28358782CC>AA	uc001iua.1	-	15	1528	c.1124_splice	c.e15-1	p.G375_splice	MPP7_uc009xkz.1_Splice_Site|MPP7_uc001iub.1_Splice_Site_p.G375_splice|MPP7_uc009xla.2_Splice_Site_p.G375_splice|MPP7_uc010qdv.1_Splice_Site	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7						establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TCCCACGGGACCTGAAAAACAG	0.46													0	0	0	0.004672	0	13	16										AA	28358782	CC	AA	28358781	5	1	71	1	0	0	0	0	0	0	1	0	9739	521	18	4	626	4	MPP7	10	28358781	Splice_Site	DNP	CC	TCGA-E7-A3Y1-01A-11D-A22Z-08	11364472	28358781	107175966	106	22075										
ADAMTS14	140766	broad.mit.edu	37	chr10	72520532	72520532	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctcagacacctacgccagtcCctgaggacaaagggcaacct	9	15	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:72520532C>G	uc001jrh.2	+	22	3595	c.3595C>G	c.(3595-3597)CCT>GCT	p.P1199A	ADAMTS14_uc001jrg.2_Missense_Mutation_p.P1202A	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1199	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TACGCCAGTCCCTGAGGACAA	0.647													0	0	0	0.059317	0	32	64										G	72520532	C	G	72520532	3	3	71	1	0	0	0	0	1	0	0	0	259	623	22	4	3690	4	ADAMTS14	10	72520532	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	44161751	72520532	63014215	107	22076										
DDIT4	54541	broad.mit.edu	37	chr10	74034625	74034625	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cctagccagttggtaagccaGgtgggcaaagaactactgcg	13	10	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:74034625G>A	uc001jsx.1	+	3	580	c.378G>A	c.(376-378)CAG>CAA	p.Q126Q		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	126					apoptosis					pancreas(1)	1						TGGTAAGCCAGGTGGGCAAAG	0.692											OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.048971	0	67	107										A	74034625	G	A	74034625	2	1	71	1	0	0	0	0	0	0	0	1	4331	991	35	2		2	DDIT4	10	74034625	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1514093	74034625	61500122	108	22077										
KNDC1	85442	broad.mit.edu	37	chr10	134981802	134981802	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccccgagttcgacgtgaccGggaacacctttgaggtaagt	12	12	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:134981802G>C	uc001llz.1	+	3	347	c.346G>C	c.(346-348)GGG>CGG	p.G116R	KNDC1_uc001lma.1_Missense_Mutation_p.G51R	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	116	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CGACGTGACCGGGAACACCTT	0.562													0	0	0	0.048971	0	63	98										C	134981802	G	C	134981802	3	2	71	1	0	0	0	0	1	0	0	0	8426	1116	39	4	356	4	KNDC1	10	134981802	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	60947177	134981802	552945	109	22078										
DBX1	120237	broad.mit.edu	37	chr11	20180780	20180780	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aaaggctgaaaagacccttcGaagtagggaaaggcgaaggt	14	6	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:20180780G>A	uc001mpw.1	-	2	426	c.426C>T	c.(424-426)TTC>TTT	p.F142F		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	142					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAGACCCTTCGAAGTAGGGAA	0.602													0	0	0	0.02938	0	7	128										A	20180780	G	A	20180780	2	1	71	1	0	0	0	0	0	0	0	1	4259	1049	37	1		1	DBX1	11	20180780	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		20180780	114825736	110	22079										
QSER1	79832	broad.mit.edu	37	chr11	32954330	32954330	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	taaaacattgactttttctgGgtcatctcagactgtaactc	6	9	3	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:32954330G>T	uc001mty.2	+	4	1406	c.1139G>T	c.(1138-1140)GGG>GTG	p.G380V	QSER1_uc001mtz.1_Intron|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	380	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ACTTTTTCTGGGTCATCTCAG	0.383													1	0	2.13384e-23	0.048971	2.35269e-23	46	69										T	32954330	G	T	32954330	3	4	71	1	0	0	0	0	1	0	0	0	12882	1232	43	4	1145	4	QSER1	11	32954330	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	12773550	32954330	102052186	111	22080										
TTC17	55761	broad.mit.edu	37	chr11	43465060	43465060	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gaatacgggtgctgaagaaaGgtccccaggatggagtggcc	16	8	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:43465060G>A	uc001mxi.2	+	17	2451	c.2437G>A	c.(2437-2439)GGT>AGT	p.G813S	TTC17_uc001mxh.2_Missense_Mutation_p.G870S|TTC17_uc010rfj.1_Missense_Mutation_p.G813S|TTC17_uc001mxj.2_Missense_Mutation_p.G640S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	813							binding			ovary(5)	5						GCTGAAGAAAGGTCCCCAGGA	0.488													0	0	0	0.038147	0	8	97										A	43465060	G	A	43465060	3	1	71	1	0	0	0	0	1	0	0	0	16681	1000	35	2	2503	2	TTC17	11	43465060	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	10510730	43465060	91541456	112	22081										
SSRP1	6749	broad.mit.edu	37	chr11	57100511	57100511	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agagacacctctgcgtcatcGttttggtggaattccagtgt	11	9	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:57100511G>A	uc001njt.2	-	5	726	c.459C>T	c.(457-459)AAC>AAT	p.N153N	SSRP1_uc010rjq.1_Silent_p.N153N	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	153					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						CTGCGTCATCGTTTTGGTGGA	0.557													0	0	0	0.048971	0	76	98										A	57100511	G	A	57100511	2	1	71	1	0	0	0	0	0	0	0	1	15193	1136	40	2		2	SSRP1	11	57100511	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	13635451	57100511	77906005	113	22082										
C11orf9	745	broad.mit.edu	37	chr11	61536739	61536739	+	Frame_Shift_Del	DEL	C	C	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctggctctcgcagcacactgCcggactctcccccagactcg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:61536739delC	uc001nsc.1	+	4	502	c.406delC	c.(406-408)CCGfs	p.P136fs	C11orf9_uc001nse.1_Frame_Shift_Del_p.P127fs	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	136	Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CAGCACACTGCCGGACTCTCC	0.682																		5	4	---	---								-	61536739	C	-	61536739	7	5	71	1	0	1	0	1	0	0	0	0	1671	739	26	0	443	0	C11orf9	11	61536739	Frame_Shift_Del	DEL	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	4436228	61536739	73469777	114	22083										
MAP3K11	4296	broad.mit.edu	37	chr11	65375774	65375774	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccttagagaaggtggaggcCttgataacctcaggagccat	12	10	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:65375774C>T	uc001oew.2	-	2	1378	c.885G>A	c.(883-885)AAG>AAA	p.K295K	MAP3K11_uc001oev.2_5'Flank|MAP3K11_uc010rol.1_Silent_p.K38K|MAP3K11_uc001oex.1_5'UTR	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	295	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						AGGTGGAGGCCTTGATAACCT	0.627													0	0	0	0.016522	0	22	63										T	65375774	C	T	65375774	2	4	71	1	0	0	0	0	0	0	0	1	9245	680	24	2		2	MAP3K11	11	65375774	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	3839035	65375774	69630742	115	22084										
GRM5	2915	broad.mit.edu	37	chr11	88583193	88583193	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gccttgggcaagtgacttgtGagcttcttcagcagcttatc	11	10	2	2	rs145650472		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:88583193G>A	uc001pcq.2	-	2	992	c.792C>T	c.(790-792)CTC>CTT	p.L264L	GRM5_uc009yvm.2_Silent_p.L264L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	264	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGTGACTTGTGAGCTTCTTCA	0.547													0	0	0	0.041601	0	27	42										A	88583193	G	A	88583193	2	1	71	1	0	0	0	0	0	0	0	1	6800	1277	45	1		1	GRM5	11	88583193	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	23207419	88583193	46423323	116	22085										
CNTN5	53942	broad.mit.edu	37	chr11	99944885	99944886	+	Missense_Mutation	DNP	CC	CC	AA													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttttttaatagcttcagctcCcacttttgcactgaatcaac							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:99944885_99944886CC>AA	uc001pga.2	+	13	1778_1779	c.1439_1440CC>AA	c.(1438-1440)CCC>CAA	p.P480Q	CNTN5_uc009ywv.1_Missense_Mutation_p.P480Q|CNTN5_uc001pfz.2_Missense_Mutation_p.P480Q|CNTN5_uc001pgb.2_Missense_Mutation_p.P406Q	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	480	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GCTTCAGCTCCCACTTTTGCAC	0.366													0	0	0	0.004672	0	11	8										AA	99944886	CC	AA	99944885	3	1	71	1	0	0	0	0	1	0	0	0	3644	623	22	4	1481	4	CNTN5	11	99944885	Missense_Mutation	DNP	CC	TCGA-E7-A3Y1-01A-11D-A22Z-08	11361692	99944885	35061631	117	22086										
DYNC2H1	79659	broad.mit.edu	37	chr11	103124075	103124075	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tacaatgaagaattccgcctCtttttgtcaacaagaaaccc	5	11	2	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:103124075C>G	uc001pho.2	+	66	10248	c.10104C>G	c.(10102-10104)CTC>CTG	p.L3368L	DYNC2H1_uc001phn.1_Silent_p.L3375L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3368	AAA 5 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AATTCCGCCTCTTTTTGTCAA	0.373													0	0	0	0.050027	0	34	52										G	103124075	C	G	103124075	2	3	71	1	0	0	0	0	0	0	0	1	4846	900	32	1		1	DYNC2H1	11	103124075	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	3179190	103124075	31882441	118	22087										
DDI1	414301	broad.mit.edu	37	chr11	103908520	103908520	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctttctccatacttgaggatCaacccatggatatgcttcta	6	11	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:103908520C>A	uc001phr.2	+	1	1213	c.970C>A	c.(970-972)CAA>AAA	p.Q324K	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	324					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		ACTTGAGGATCAACCCATGGA	0.448													1	0	1.06522e-23	0.045515	1.18053e-23	46	83										A	103908520	C	A	103908520	3	1	71	1	0	0	0	0	1	0	0	0	4328	827	29	3	972	3	DDI1	11	103908520	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	784445	103908520	31097996	119	22088										
NCAM1	4684	broad.mit.edu	37	chr11	113145992	113145992	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttcctgattctctgcaggaaGggccccgtagaagcaaagcc	11	12	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:113145992G>A	uc001pns.2	+	6	748	c.716G>A	c.(715-717)AGG>AAG	p.R239K	uc010rwu.1_5'Flank|NCAM1_uc001pnt.2_Silent_p.K55K			P13591	NCAM1_HUMAN	SubName: Full=cDNA FLJ52974, highly similar to Neural cell adhesion molecule 1, 140 kDa isoform;	Error:Variant_position_missing_in_P13591_after_alignment					axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCTGCAGGAAGGGCCCCGTAG	0.592													0	0	0	0.038395	0	18	23										A	113145992	G	A	113145992	3	1	71	1	0	0	0	0	1	0	0	0	10202	991	35	2	2736	2	NCAM1	11	113145992	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	9237472	113145992	21860524	120	22089										
MLL	4297	broad.mit.edu	37	chr11	118348798	118348798	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctccagtaaagaaaggacgtCgatcgaggcggtgtgggcag	16	8	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:118348798C>T	uc001pta.2	+	5	3474	c.3451C>T	c.(3451-3453)CGA>TGA	p.R1151*	MLL_uc001ptb.2_Nonsense_Mutation_p.R1151*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1151	CXXC-type.			R->A: Impairs DNA-binding.	apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAAAGGACGTCGATCGAGGCG	0.512			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.021523	0	23	249										T	118348798	C	T	118348798	4	4	71	1	0	0	0	0	0	1	0	0	9620	876	31	1	3469	1	MLL	11	118348798	Nonsense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	5202806	118348798	16657718	121	22090										
PANX3	116337	broad.mit.edu	37	chr11	124489476	124489476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tttccagattgttagcctctCcagtgtagcaatatacacca	6	11	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:124489476C>T	uc001qah.2	+	4	824	c.824C>T	c.(823-825)TCC>TTC	p.S275F		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	275	Helical; (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		GTTAGCCTCTCCAGTGTAGCA	0.458													0	0	0	0.062417	0	22	47										T	124489476	C	T	124489476	3	4	71	1	0	0	0	0	1	0	0	0	11422	855	30	1	838	1	PANX3	11	124489476	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	6140678	124489476	10517040	122	22091										
TULP3	7289	broad.mit.edu	37	chr12	3040245	3040245	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctactgccgcccaaccagctGataacctcctgggagacata	8	15	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:3040245G>C	uc010seh.1	+	6	616	c.535G>C	c.(535-537)GAT>CAT	p.D179H	TULP3_uc010sef.1_RNA|TULP3_uc009zec.1_5'UTR|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.D179H|TULP3_uc010sei.1_Missense_Mutation_p.D36H	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	179				TSGSATAAQPADNL -> IPVLLLPPNQLITF (in Ref. 1).	G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CCAACCAGCTGATAACCTCCT	0.507													0	0	0	0.048971	0	48	80										C	3040245	G	C	3040245	3	2	71	1	0	0	0	0	1	0	0	0	16772	1290	45	1	557	1	TULP3	12	3040245	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		3040245	130811650	123	22092										
KCNA5	3741	broad.mit.edu	37	chr12	5154246	5154246	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gccccgccctctggccctacGgtggcaccgctcctgcccag	11	21	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:5154246G>A	uc001qni.2	+	1	1162	c.933G>A	c.(931-933)ACG>ACA	p.T311T		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	311						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CTGGCCCTACGGTGGCACCGC	0.711													0	0	0	0.048971	0	53	91										A	5154246	G	A	5154246	2	1	71	1	0	0	0	0	0	0	0	1	8006	1103	39	2		2	KCNA5	12	5154246	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	2114001	5154246	128697649	124	22093										
LTBR	4055	broad.mit.edu	37	chr12	6499851	6499851	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aatggcattcatgtcaccggCgggtctatgactatcactgg	11	10	4	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:6499851C>T	uc001qny.1	+	10	1224	c.1056C>T	c.(1054-1056)GGC>GGT	p.G352G	LTBR_uc010sfc.1_Silent_p.G333G|LTBR_uc001qnz.1_Silent_p.G347G	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	352	Cytoplasmic (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						ATGTCACCGGCGGGTCTATGA	0.562													0	0	0	0.048971	0	96	98										T	6499851	C	T	6499851	2	4	71	1	0	0	0	0	0	0	0	1	9077	755	27	2		2	LTBR	12	6499851	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	1345605	6499851	127352044	125	22094										
AICDA	57379	broad.mit.edu	37	chr12	8758001	8758001	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gggctccaggaggtgaaccaGgtgacgcggtagcagcggcc	18	11	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:8758001G>A	uc001qur.2	-	3	316	c.237C>T	c.(235-237)ACC>ACT	p.T79T	AICDA_uc001qup.1_Silent_p.T74T|AICDA_uc001quq.1_Silent_p.T74T|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	79					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					AGGTGAACCAGGTGACGCGGT	0.627									Immune_Deficiency_with_Hyper-IgM				0	0	0	0.01892	0	25	66										A	8758001	G	A	8758001	2	1	71	1	0	0	0	0	0	0	0	1	422	987	35	2		2	AICDA	12	8758001	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	2258150	8758001	125093894	126	22095										
C12orf36	283422	broad.mit.edu	37	chr12	13526293	13526293	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tagtggatttcccaggggagGagctcgtgcaatccagcaga	14	9	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:13526293G>A	uc001rbs.1	-	3	480	c.262C>T	c.(262-264)CCT>TCT	p.P88S		NM_182558	NP_872364			hypothetical protein LOC283422												0				BRCA - Breast invasive adenocarcinoma(232;0.198)		CCCAGGGGAGGAGCTCGTGCA	0.463													0	0	0	0.048971	0	63	81										A	13526293	G	A	13526293	3	1	71	1	0	0	0	0	1	0	0	0	1683	1174	41	1	158	1	C12orf36	12	13526293	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	4768292	13526293	120325602	127	22096										
SLCO1C1	53919	broad.mit.edu	37	chr12	20874968	20874968	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agggagaaaatgcaaaaataAtggaaatggcaagaggtaag	13	2	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:20874968A>T	uc001rej.3	+	9	1361	c.1006A>T	c.(1006-1008)ATG>TTG	p.M336L	SLCO1C1_uc010sii.1_Missense_Mutation_p.M336L|SLCO1C1_uc010sij.1_Missense_Mutation_p.M287L|SLCO1C1_uc009zip.2_Missense_Mutation_p.M170L|SLCO1C1_uc001rei.2_Missense_Mutation_p.M336L|SLCO1C1_uc010sik.1_Missense_Mutation_p.M218L	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	336	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TGCAAAAATAATGGAAATGGC	0.264													0	0	0	0.024245	0	14	27										T	20874968	A	T	20874968	3	4	71	1	0	0	0	0	1	0	0	0	14725	101	4	5	1032	5	SLCO1C1	12	20874968	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	7348675	20874968	112976927	128	22097										
PLEKHA9	51054	broad.mit.edu	37	chr12	45567306	45567306	+	Frame_Shift_Del	DEL	A	A	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcttcagtcgctgagttcctAacctgggctacatccgcctc							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:45567306delA	uc001rom.1	-	3	1380	c.843delT	c.(841-843)GTTfs	p.V281fs	PLEKHA9_uc009zke.2_Frame_Shift_Del_p.V281fs	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		CTGAGTTCCTAACCTGGGCTA	0.418																		33	57	---	---								-	45567306	A	-	45567306	7	5	71	1	0	1	0	1	0	0	0	0	12063	349	13	0	336	0	PLEKHA9	12	45567306	Frame_Shift_Del	DEL	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	24692338	45567306	88284589	129	22098										
MLL2	8085	broad.mit.edu	37	chr12	49425478	49425478	+	Frame_Shift_Del	DEL	G	G	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gggtccctggatgggtgggaGggagctgggcctcagtggga							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:49425478delG	uc001rta.3	-	39	13010	c.13010delC	c.(13009-13011)CCTfs	p.P4337fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4337	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATGGGTGGGAGGGAGCTGGGC	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								17	16	---	---								-	49425478	G	-	49425478	7	5	71	1	0	1	0	1	0	0	0	0	9621	1000	35	0	3667	0	MLL2	12	49425478	Frame_Shift_Del	DEL	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	3858172	49425478	84426417	130	22099										
FAM186B	84070	broad.mit.edu	37	chr12	49994518	49994518	+	Frame_Shift_Del	DEL	C	C	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggagaaggtcatggtaccttCcccctaagatctctacctgc							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:49994518delC	uc001ruo.2	-	4	1078	c.905delG	c.(904-906)GGAfs	p.G302fs	FAM186B_uc010smk.1_Frame_Shift_Del_p.G212fs	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	302						protein complex				ovary(1)	1						ATGGTACCTTCCCCCTAAGAT	0.542																		20	226	---	---								-	49994518	C	-	49994518	7	5	71	1	0	1	0	1	0	0	0	0	5512	855	30	0	1792	0	FAM186B	12	49994518	Frame_Shift_Del	DEL	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	569040	49994518	83857377	131	22100										
KRT75	9119	broad.mit.edu	37	chr12	52827910	52827910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccccaggttgtagaggctgCggcttccaaagctggcccca	12	15	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:52827910C>T	uc001saj.2	-	1	201	c.179G>A	c.(178-180)CGC>CAC	p.R60H		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	60	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GTAGAGGCTGCGGCTTCCAAA	0.652													0	0	0	0.058154	0	10	114										T	52827910	C	T	52827910	3	4	71	1	0	0	0	0	1	0	0	0	8488	768	27	2	1512	2	KRT75	12	52827910	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	2833392	52827910	81023985	132	22101										
KRT6C	286887	broad.mit.edu	37	chr12	52862934	52862934	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	caacagagctgaggccacccCcaatggctctgccactgctg	10	16	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:52862934C>T	uc001sal.3	-	9	1655	c.1607G>A	c.(1606-1608)GGG>GAG	p.G536E		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	536	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GAGGCCACCCCCAATGGCTCT	0.592													0	0	0	0.030593	0	25	72										T	52862934	C	T	52862934	3	4	71	1	0	0	0	0	1	0	0	0	8482	623	22	2	91	2	KRT6C	12	52862934	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	35024	52862934	80988961	133	22102										
SPIC	121599	broad.mit.edu	37	chr12	101880371	101880371	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	caaaatccggaggaagctgaCttaccagttcagtgaggcca	11	10	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:101880371C>T	uc001tid.2	+	6	728	c.569C>T	c.(568-570)ACT>ATT	p.T190I	SPIC_uc009zua.2_Missense_Mutation_p.T65I|SPIC_uc010svp.1_Missense_Mutation_p.T189I	NM_152323	NP_689536	Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	190	ETS.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						AGGAAGCTGACTTACCAGTTC	0.443													0	0	0	0.016723	0	12	116										T	101880371	C	T	101880371	3	4	71	1	0	0	0	0	1	0	0	0	15050	565	20	2	581	2	SPIC	12	101880371	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	49017437	101880371	31971524	134	22103										
STAB2	55576	broad.mit.edu	37	chr12	104067714	104067714	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcgttcacggaacatgcaatAacaggatagacagcgatggg	13	8	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:104067714A>G	uc001tjw.2	+	23	2587	c.2401A>G	c.(2401-2403)AAC>GAC	p.N801D		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	801	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AACATGCAATAACAGGATAGA	0.592													0	0	0	0.045515	0	47	50										G	104067714	A	G	104067714	3	3	71	1	0	0	0	0	1	0	0	0	15237	362	13	5	2491	5	STAB2	12	104067714	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	2187343	104067714	29784181	135	22104										
STAB2	55576	broad.mit.edu	37	chr12	104092983	104092983	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gggtttctcctatttccttaGcttctttctccataatgacc	5	12	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:104092983G>A	uc001tjw.2	+	34	3878	c.3692G>A	c.(3691-3693)AGC>AAC	p.S1231N		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1231	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TATTTCCTTAGCTTCTTTCTC	0.473													0	0	0	0.0333	0	16	26										A	104092983	G	A	104092983	3	1	71	1	0	0	0	0	1	0	0	0	15237	971	34	2	3826	2	STAB2	12	104092983	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	25269	104092983	29758912	136	22105										
MLXIP	22877	broad.mit.edu	37	chr12	122626341	122626341	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gctgtcaccaggattggcaaGagattgggagagtcctagct	14	8	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:122626341G>A	uc001ubq.2	+	17	2742	c.2742G>A	c.(2740-2742)AAG>AAA	p.K914K	MLXIP_uc001ubt.2_Silent_p.K521K	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	914					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GGATTGGCAAGAGATTGGGAG	0.622													0	0	0	0.036044	0	40	73										A	122626341	G	A	122626341	2	1	71	1	0	0	0	0	0	0	0	1	9636	933	33	1		1	MLXIP	12	122626341	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	18533358	122626341	11225554	137	22106										
TMEM132B	114795	broad.mit.edu	37	chr12	126138270	126138270	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aatggccaattgtggttgcaGagggtgaaggacaagggcct	16	6	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:126138270G>T	uc001uhe.1	+	9	2259	c.2251G>T	c.(2251-2253)GAG>TAG	p.E751*	TMEM132B_uc001uhf.1_Nonsense_Mutation_p.E263*	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	751	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TGTGGTTGCAGAGGGTGAAGG	0.433													1	0	1.30916e-28	0.048971	1.48142e-28	50	89										T	126138270	G	T	126138270	4	4	71	1	0	0	0	0	0	1	0	0	16043	943	33	3	2285	3	TMEM132B	12	126138270	Nonsense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	3511929	126138270	7713625	138	22107										
PCDH20	64881	broad.mit.edu	37	chr13	61987073	61987073	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggactccagaacacttcctcCaatcttactgaaaagtttaa	5	11	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr13:61987073C>A	uc001vid.3	-	2	1523	c.1159G>T	c.(1159-1161)GGA>TGA	p.G387*	PCDH20_uc010thj.1_Nonsense_Mutation_p.G387*	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	360	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		ACACTTCCTCCAATCTTACTG	0.398													1	0	1.61742e-36	0.048971	1.86959e-36	58	96										A	61987073	C	A	61987073	4	1	71	1	0	0	0	0	0	1	0	0	11515	603	21	4	1700	4	PCDH20	13	61987073	Nonsense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		61987073	53182805	139	22108										
KLF5	688	broad.mit.edu	37	chr13	73636642	73636642	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acaggccacttactttccccCgtcaccaccaagctcagagc	6	18	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr13:73636642C>A	uc001vje.2	+	2	1229	c.905C>A	c.(904-906)CCG>CAG	p.P302Q	KLF5_uc001vjd.2_Missense_Mutation_p.P211Q	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	302					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TACTTTCCCCCGTCACCACCA	0.502													1	0	2.89935e-36	0.048971	3.33348e-36	67	63										A	73636642	C	A	73636642	3	1	71	1	0	0	0	0	1	0	0	0	8349	652	23	4	911	4	KLF5	13	73636642	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	11649569	73636642	41533236	140	22109										
OR4N2	390429	broad.mit.edu	37	chr14	20296395	20296395	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	catctacacgcgccccttcaGggctttcccagctgacaagg	9	16	2	1	rs148867085		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:20296395G>T	uc010tkv.1	+	1	788	c.788G>T	c.(787-789)AGG>ATG	p.R263M		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CGCCCCTTCAGGGCTTTCCCA	0.458													1	0	4.6707e-30	0.048971	5.31323e-30	52	73										T	20296395	G	T	20296395	3	4	71	1	0	0	0	0	1	0	0	0	11077	1000	35	4	790	4	OR4N2	14	20296395	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		20296395	87053145	141	22110										
PRKD1	5587	broad.mit.edu	37	chr14	30100021	30100021	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agggcatgctggatggctatCtcccacatcctggccacatc	10	14	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:30100021C>T	uc001wqh.2	-	10	1780	c.1599G>A	c.(1597-1599)GAG>GAA	p.E533E		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	533	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGATGGCTATCTCCCACATCC	0.522													0	0	0	0.047766	0	9	135										T	30100021	C	T	30100021	2	4	71	1	0	0	0	0	0	0	0	1	12518	912	32	1		1	PRKD1	14	30100021	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	9803626	30100021	77249519	142	22111										
FANCM	57697	broad.mit.edu	37	chr14	45605269	45605269	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aagaacgctttttcagacgtGgggctcaagtatctcccgat	10	10	3	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:45605269G>A	uc001wwd.3	+	1	134	c.35G>A	c.(34-36)TGG>TAG	p.W12*	FANCM_uc001wwc.2_Nonsense_Mutation_p.W12*|FANCM_uc010anf.2_Nonsense_Mutation_p.W12*|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	12					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TTTCAGACGTGGGGCTCAAGT	0.587								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.042209	0	47	81										A	45605269	G	A	45605269	4	1	71	1	0	0	0	0	0	1	0	0	5671	1357	47	2	37	2	FANCM	14	45605269	Nonsense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	15505248	45605269	61744271	143	22112										
C14orf104	55172	broad.mit.edu	37	chr14	50100212	50100212	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aatttgtaccagaggggattCaaatctccttgaagactttg	9	7	2	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:50100212C>A	uc001wws.3	-	1	1737	c.1656G>T	c.(1654-1656)TTG>TTT	p.L552F	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.L552F	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	552					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					AGAGGGGATTCAAATCTCCTT	0.443									Kartagener_syndrome				1	0	3.32936e-07	0.038395	3.45803e-07	17	48										A	50100212	C	A	50100212	3	1	71	1	0	0	0	0	1	0	0	0	1736	825	29	3	869	3	C14orf104	14	50100212	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	4494943	50100212	57249328	144	22113										
NID2	22795	broad.mit.edu	37	chr14	52474664	52474664	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	attttaggagcttctctattCcagtctgtccagtacaagtt	7	9	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:52474664C>T	uc001wzo.2	-	19	3978	c.3744G>A	c.(3742-3744)TGG>TGA	p.W1248*	NID2_uc010tqs.1_Nonsense_Mutation_p.W1200*|NID2_uc010tqt.1_Nonsense_Mutation_p.W1248*	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1248	LDL-receptor class B 3.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CTTCTCTATTCCAGTCTGTCC	0.239													0	0	0	0.014758	0	5	54										T	52474664	C	T	52474664	4	4	71	1	0	0	0	0	0	1	0	0	10415	856	30	1	399	1	NID2	14	52474664	Nonsense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	2374452	52474664	54874876	145	22114										
SLC35F4	341880	broad.mit.edu	37	chr14	58038711	58038711	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tatgccatcatgacaatgccGgtaattgccattattgcagc	8	10	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:58038711G>A	uc001xdb.1	-	5	942	c.942C>T	c.(940-942)ACC>ACT	p.T314T	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Silent_p.T155T	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TGACAATGCCGGTAATTGCCA	0.433													0	0	0	0.008291	0	9	12										A	58038711	G	A	58038711	2	1	71	1	0	0	0	0	0	0	0	1	14591	1103	39	2		2	SLC35F4	14	58038711	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	5564047	58038711	49310829	146	22115										
SLC10A1	6554	broad.mit.edu	37	chr14	70252943	70252943	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttgtccttcaggtccccatcAtagatccccctggagtagat	8	13	2	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:70252943A>G	uc001xlr.2	-	2	572	c.438T>C	c.(436-438)TAT>TAC	p.Y146Y		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	146					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		GGTCCCCATCATAGATCCCCC	0.522													0	0	0	0.048971	0	56	72										G	70252943	A	G	70252943	2	3	71	1	0	0	0	0	0	0	0	1	14373	224	8	5		5	SLC10A1	14	70252943	Silent	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	12214232	70252943	37096597	147	22116										
KIAA1409	57578	broad.mit.edu	37	chr14	94088092	94088092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aacaaaaatctcttgatataGggaatgcagactcgcttttg	8	7	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:94088092G>A	uc001ybv.1	+	28	4131	c.4048G>A	c.(4048-4050)GGG>AGG	p.G1350R	KIAA1409_uc001ybs.1_Missense_Mutation_p.G1328R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1505						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCTTGATATAGGGAATGCAGA	0.438													0	0	0	0.059317	0	33	64										A	94088092	G	A	94088092	3	1	71	1	0	0	0	0	1	0	0	0	8230	1000	35	2	4088	2	KIAA1409	14	94088092	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	23835149	94088092	13261448	148	22117										
ZNF839	55778	broad.mit.edu	37	chr14	102808061	102808061	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gacacctcggcaaggtttgtGacttccacctgaaccaccag	9	14	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:102808061G>A	uc001ylo.2	+	8	2331	c.1981G>A	c.(1981-1983)GAC>AAC	p.D661N	ZNF839_uc010awk.1_Missense_Mutation_p.D777N|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Intron|ZNF839_uc001ylr.2_Missense_Mutation_p.D586N|ZNF839_uc001yls.2_Missense_Mutation_p.D278N|ZNF839_uc001ylt.2_Missense_Mutation_p.D251N	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	661						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAAGGTTTGTGACTTCCACCT	0.622													0	0	0	0.047766	0	9	120										A	102808061	G	A	102808061	3	1	71	1	0	0	0	0	1	0	0	0	18185	1290	45	1	2359	1	ZNF839	14	102808061	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	8719969	102808061	4541479	149	22118										
DUOX2	50506	broad.mit.edu	37	chr15	45403752	45403752	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcgaggagccatagatggcgCtgccgtccagccagcccgtc	14	15	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:45403752C>T	uc010bea.2	-	6	748	c.545G>A	c.(544-546)AGC>AAC	p.S182N	DUOX2_uc001zun.2_Missense_Mutation_p.S182N|DUOXA2_uc001zuo.2_5'Flank|DUOXA2_uc010beb.2_5'Flank	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	182	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ATAGATGGCGCTGCCGTCCAG	0.766													0	0	0	0.009096	0	4	9										T	45403752	C	T	45403752	3	4	71	1	0	0	0	0	1	0	0	0	4801	797	28	2	4217	2	DUOX2	15	45403752	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		45403752	57127640	150	22119										
DAPK2	23604	broad.mit.edu	37	chr15	64275760	64275760	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gatgagcaccacgtcggtgcGgttctcatagacgtcgtgca	13	11	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:64275760G>T	uc002amr.2	-	3	317	c.286C>A	c.(286-288)CGC>AGC	p.R96S	DAPK2_uc010uim.1_Intron|DAPK2_uc010bgu.1_Missense_Mutation_p.R86S	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	death-associated kinase 2	96	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2				LUAD - Lung adenocarcinoma(2;0.215)		ACGTCGGTGCGGTTCTCATAG	0.652													1	0	1.52319e-26	0.033182	1.69681e-26	37	66										T	64275760	G	T	64275760	3	4	71	1	0	0	0	0	1	0	0	0	4236	1116	39	4	866	4	DAPK2	15	64275760	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	18872008	64275760	38255632	151	22120										
CELF6	60677	broad.mit.edu	37	chr15	72608188	72608188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ccaacctggaggacttacccCtggcagggtcttctgctcgt	11	14	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:72608188C>T	uc002auh.2	-	2	653	c.343G>A	c.(343-345)GGG>AGG	p.G115R	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Missense_Mutation_p.G115R|CELF6_uc002aui.2_Missense_Mutation_p.R237K|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	115	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						GGACTTACCCCTGGCAGGGTC	0.642													0	0	0	0.004672	0	3	9										T	72608188	C	T	72608188	3	4	71	1	0	0	0	0	1	0	0	0	3220	681	24	2	1146	2	CELF6	15	72608188	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	8332428	72608188	29923204	152	22121										
OR4F6	390648	broad.mit.edu	37	chr15	102346616	102346616	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttcagaaaaaatcttcaggtGgtatattcaaggctttctct	7	7	5	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:102346616G>C	uc010utr.1	+	1	694	c.694G>C	c.(694-696)GGT>CGT	p.G232R		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			ATCTTCAGGTGGTATATTCAA	0.353													0	0	0	0.048971	0	54	115										C	102346616	G	C	102346616	3	2	71	1	0	0	0	0	1	0	0	0	11066	1348	47	4	696	4	OR4F6	15	102346616	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	29738428	102346616	184776	153	22122										
MSLN	10232	broad.mit.edu	37	chr16	813678	813678	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acggagtcctggccaacccaCctaacatttccaggtgggtc	10	14	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:813678C>G	uc002cjw.1	+	4	217	c.166C>G	c.(166-168)CCT>GCT	p.P56A	MSLN_uc002cjt.1_Missense_Mutation_p.P56A|MSLN_uc002cju.1_Missense_Mutation_p.P56A|MSLN_uc010brd.1_Missense_Mutation_p.P55A|MSLN_uc002cjv.1_Missense_Mutation_p.P56A|MSLN_uc002cjx.1_Missense_Mutation_p.P56A|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	56				ANPP -> TTPH (in Ref. 2; AAC50348).	cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GGCCAACCCACCTAACATTTC	0.662													0	0	0	0.020292	0	14	12										G	813678	C	G	813678	3	3	71	1	0	0	0	0	1	0	0	0	9881	507	18	4	176	4	MSLN	16	813678	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		813678	89541075	154	22123										
RNPS1	10921	broad.mit.edu	37	chr16	2305696	2305696	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggccagggggccagcacggcGgtggcagtgatctcctggcc	18	13	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:2305696G>A	uc002cpt.2	-	7	1254	c.708C>T	c.(706-708)ACC>ACT	p.T236T	RNPS1_uc002cpu.2_Silent_p.T236T|RNPS1_uc002cpv.2_Silent_p.T59T|RNPS1_uc002cpw.2_Silent_p.T236T|RNPS1_uc002cpx.2_Silent_p.T213T|RNPS1_uc010uwa.1_RNA	NM_080594	NP_542161	Q15287	RNPS1_HUMAN	RNA-binding protein S1, serine-rich domain	236	Necessary for interaction with PNN and exon-skipping.|RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(1)	1						CCAGCACGGCGGTGGCAGTGA	0.562													0	0	0	0.043863	0	20	36										A	2305696	G	A	2305696	2	1	71	1	0	0	0	0	0	0	0	1	13511	1103	39	2		2	RNPS1	16	2305696	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1492018	2305696	88049057	155	22124										
SMG1	23049	broad.mit.edu	37	chr16	18849753	18849753	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ttcaatgttttgtgtcattcGaaaaggtactttctcaggaa	8	6	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:18849753G>A	uc002dfm.2	-	44	7483	c.7120C>T	c.(7120-7122)CGA>TGA	p.R2374*	SMG1_uc010bwb.2_Nonsense_Mutation_p.R2234*|SMG1_uc010bwa.2_Nonsense_Mutation_p.R1105*	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2374	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGTGTCATTCGAAAAGGTACT	0.373													0	0	0	0.02938	0	7	76										A	18849753	G	A	18849753	4	1	71	1	0	0	0	0	0	1	0	0	14795	1066	37	1	3945	1	SMG1	16	18849753	Nonsense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	16544057	18849753	71505000	156	22125										
NFATC2IP	84901	broad.mit.edu	37	chr16	28965901	28965901	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccagaggcagagctggcagAttcgagtggtctctaccatg	13	11	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:28965901A>T	uc002dru.2	+	3	491	c.476A>T	c.(475-477)GAT>GTT	p.D159V	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Intron	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	159						cytoplasm|nucleus				ovary(1)	1						GAGCTGGCAGATTCGAGTGGT	0.522													0	0	0	0.048971	0	89	149										T	28965901	A	T	28965901	3	4	71	1	0	0	0	0	1	0	0	0	10363	333	12	5	486	5	NFATC2IP	16	28965901	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	10116148	28965901	61388852	157	22126										
IRX3	79191	broad.mit.edu	37	chr16	54319028	54319028	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gcgccgtctaagttctccaaAtcgatctcctcgtcctcgtc	7	16	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:54319028A>G	uc002eht.1	-	2	1181	c.765T>C	c.(763-765)GAT>GAC	p.D255D		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	255	Asp/Glu-rich (acidic).				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGTTCTCCAAATCGATctcct	0.403													0	0	0	0.0333	0	18	23										G	54319028	A	G	54319028	2	3	71	1	0	0	0	0	0	0	0	1	7845	98	4	5		5	IRX3	16	54319028	Silent	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	25353127	54319028	36035725	158	22127										
MMP2	4313	broad.mit.edu	37	chr16	55525777	55525777	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	atggggctggagcactcccaAgaccctggggccctgatggc	15	13	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:55525777A>G	uc002ehz.3	+	8	1556	c.1245A>G	c.(1243-1245)CAA>CAG	p.Q415Q	MMP2_uc010vhd.1_Silent_p.Q339Q|MMP2_uc010ccc.2_Silent_p.Q365Q|MMP2_uc002eia.3_5'Flank	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	415	Required for inhibitor TIMP2 binding.|Collagenase-like 2.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGCACTCCCAAGACCCTGGGG	0.577													0	0	0	0.025465	0	41	75										G	55525777	A	G	55525777	2	3	71	1	0	0	0	0	0	0	0	1	9658	69	3	5		5	MMP2	16	55525777	Silent	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	1206749	55525777	34828976	159	22128										
KARS	3735	broad.mit.edu	37	chr16	75665679	75665679	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gtggtgaactcaggattgtgCgtcaaatcaatcccctcatt	9	10	4	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:75665679C>T	uc002feq.2	-	8	1038	c.990G>A	c.(988-990)ACG>ACA	p.T330T	KARS_uc002fer.2_Silent_p.T358T|KARS_uc002fes.2_Silent_p.T174T	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	330					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	CAGGATTGTGCGTCAAATCAA	0.493													0	0	0	0.048971	0	87	135										T	75665679	C	T	75665679	2	4	71	1	0	0	0	0	0	0	0	1	7980	755	27	2		2	KARS	16	75665679	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	20139902	75665679	14689074	160	22129										
OR1A2	26189	broad.mit.edu	37	chr17	3101305	3101305	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccacactctgctcacagctAgtttgtccttctgtggcaac	7	15	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:3101305A>G	uc002fvd.1	+	1	493	c.493A>G	c.(493-495)AGT>GGT	p.S165G		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCTCACAGCTAGTTTGTCCTT	0.458													0	0	0	0.048971	0	49	73										G	3101305	A	G	3101305	3	3	71	1	0	0	0	0	1	0	0	0	10950	420	15	5	495	5	OR1A2	17	3101305	Missense_Mutation	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08		3101305	78093905	161	22130										
GPR179	440435	broad.mit.edu	37	chr17	36486976	36486976	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggctctgggtagcctctctcCcaccgtcaggttgtgggcgc	14	14	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:36486976C>G	uc002hpz.2	-	11	2497	c.2476G>C	c.(2476-2478)GGA>CGA	p.G826R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	826	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCCTCTCTCCCACCGTCAGG	0.667													0	0	0	0.008291	0	10	17										G	36486976	C	G	36486976	3	3	71	1	0	0	0	0	1	0	0	0	6674	632	22	4	4631	4	GPR179	17	36486976	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	33385671	36486976	44708234	162	22131										
C17orf65	339201	broad.mit.edu	37	chr17	42254079	42254079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccaagccttcaggattttcCtcaggaccttgctctcttgt	7	14	3	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:42254079C>T	uc002ifn.2	-	4	1518	c.542G>A	c.(541-543)AGG>AAG	p.R181K	ASB16_uc002ifl.1_Intron|ASB16_uc002ifm.1_Intron	NM_178542	NP_848637	Q495Z4	CQ065_HUMAN	hypothetical protein LOC339201	181											0		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CAGGATTTTCCTCAGGACCTT	0.597													0	0	0	0.048971	0	71	142										T	42254079	C	T	42254079	3	4	71	1	0	0	0	0	1	0	0	0	1873	681	24	2	43	2	C17orf65	17	42254079	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	5767103	42254079	38941131	163	22132										
MYST2	11143	broad.mit.edu	37	chr17	47874209	47874209	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cagcagcagcctaccccagtGacaccgaaaaaataccctct	6	16	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:47874209G>A	uc002ipm.2	+	3	387	c.261G>A	c.(259-261)GTG>GTA	p.V87V	MYST2_uc002ipl.1_Silent_p.V87V|MYST2_uc010wma.1_Intron|MYST2_uc010wmb.1_Silent_p.V87V|MYST2_uc010wmc.1_Intron|MYST2_uc010wmd.1_5'UTR|MYST2_uc010wme.1_5'UTR	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	87					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CTACCCCAGTGACACCGAAAA	0.488													0	0	0	0.030593	0	23	263										A	47874209	G	A	47874209	2	1	71	1	0	0	0	0	0	0	0	1	10103	1277	45	1		1	MYST2	17	47874209	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	5620130	47874209	33321001	164	22133										
AKAP1	8165	broad.mit.edu	37	chr17	55183204	55183204	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gaccaggaacacgcagagatGacagtacaaagctggagcta	12	9	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:55183204G>A	uc002iux.2	+	2	610	c.379G>A	c.(379-381)GAC>AAC	p.D127N	AKAP1_uc010wnl.1_Missense_Mutation_p.D127N|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Missense_Mutation_p.D127N	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	127					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					ACGCAGAGATGACAGTACAAA	0.522													0	0	0	0.045705	0	32	47										A	55183204	G	A	55183204	3	1	71	1	0	0	0	0	1	0	0	0	445	1290	45	1	381	1	AKAP1	17	55183204	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	7308995	55183204	26012006	165	22134										
C17orf47	284083	broad.mit.edu	37	chr17	56619289	56619289	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggaaaagcacagaccttttaGccaccagatgacacgattgt	9	10	0	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:56619289G>A	uc002iwq.1	-	2	1736	c.1600C>T	c.(1600-1602)CTA>TTA	p.L534L	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	534										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGACCTTTTAGCCACCAGATG	0.507													0	0	0	0.023175	0	41	74										A	56619289	G	A	56619289	2	1	71	1	0	0	0	0	0	0	0	1	1858	962	34	2		2	C17orf47	17	56619289	Silent	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1436085	56619289	24575921	166	22135										
SLC16A5	9121	broad.mit.edu	37	chr17	73100105	73100105	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aacaactttagctatgttttCtacatgtccagcttcttcct	4	11	2	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:73100105C>T	uc002jmr.2	+	6	1566	c.1194C>T	c.(1192-1194)TTC>TTT	p.F398F	SLC16A5_uc002jms.1_Silent_p.F398F|SLC16A5_uc002jmt.2_Silent_p.F398F|SLC16A5_uc002jmu.2_Silent_p.F398F|SLC16A5_uc010wrt.1_Silent_p.F438F	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	398	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GCTATGTTTTCTACATGTCCA	0.493													0	0	0	0.024245	0	13	117										T	73100105	C	T	73100105	2	4	71	1	0	0	0	0	0	0	0	1	14411	912	32	1		1	SLC16A5	17	73100105	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	16480816	73100105	8095105	167	22136										
MBD1	4152	broad.mit.edu	37	chr18	47802020	47802020	+	Frame_Shift_Del	DEL	G	G	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctggcgcctgagaccagggcGgggagggcgaaggcagatgg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr18:47802020delG	uc010dow.1	-	8	1179	c.742delC	c.(742-744)CGCfs	p.R248fs	MBD1_uc002lef.2_Frame_Shift_Del_p.R30fs|MBD1_uc002leg.2_Frame_Shift_Del_p.R199fs|MBD1_uc010xdi.1_Frame_Shift_Del_p.R274fs|MBD1_uc002leh.3_Frame_Shift_Del_p.R248fs|MBD1_uc002len.2_Frame_Shift_Del_p.R248fs|MBD1_uc002lei.3_Frame_Shift_Del_p.R248fs|MBD1_uc002lej.3_Frame_Shift_Del_p.R248fs|MBD1_uc002lek.3_Frame_Shift_Del_p.R199fs|MBD1_uc002lel.3_Frame_Shift_Del_p.R248fs|MBD1_uc002lem.3_Frame_Shift_Del_p.R248fs|MBD1_uc010xdj.1_Frame_Shift_Del_p.R248fs|MBD1_uc010xdk.1_Frame_Shift_Del_p.R248fs|MBD1_uc010dox.1_Frame_Shift_Del_p.R248fs|MBD1_uc002leo.2_Frame_Shift_Del_p.R248fs	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	248	CXXC-type 2.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGACCAGGGCGGGGAGGGCGA	0.632																		28	49	---	---								-	47802020	G	-	47802020	7	5	71	1	0	1	0	1	0	0	0	0	9342	1116	39	0	1305	0	MBD1	18	47802020	Frame_Shift_Del	DEL	G	TCGA-E7-A3Y1-01A-11D-A22Z-08		47802020	30275228	168	22137										
ONECUT2	9480	broad.mit.edu	37	chr18	55103602	55103602	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agtccctacaaggagatgccCggcatgagccagagcctgtc	12	13	0	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr18:55103602C>A	uc002lgo.2	+	1	686	c.654C>A	c.(652-654)CCC>CCA	p.P218P		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	218					organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		AGGAGATGCCCGGCATGAGCC	0.687													1	0	0.00741294	0.043863	0.00751784	20	29										A	55103602	C	A	55103602	2	1	71	1	0	0	0	0	0	0	0	1	10869	639	23	4		4	ONECUT2	18	55103602	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	7301582	55103602	22973646	169	22138										
SBNO2	22904	broad.mit.edu	37	chr19	1110743	1110743	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	caccccggcacctgtgctcaCccaggatgcccatgtcgtat	9	17	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:1110743C>A	uc002lrk.3	-	26	3266	c.3028_splice	c.e26+1	p.D1010_splice	SBNO2_uc002lri.3_5'Flank|SBNO2_uc002lrj.3_Splice_Site_p.D953_splice|SBNO2_uc010dse.2_Splice_Site_p.D993_splice|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1						macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGTGCTCACCCAGGATGCC	0.637													1	0	1.11015e-26	0.048971	1.24314e-26	52	85										A	1110743	C	A	1110743	5	1	71	1	0	0	0	0	0	0	1	0	13863	521	18	4	1099	4	SBNO2	19	1110743	Splice_Site	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		1110743	58018240	170	22139										
ATCAY	85300	broad.mit.edu	37	chr19	3905458	3905458	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ccaacacgctaaatttcaacGgagcgcatcgtaagaggaag	10	10	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:3905458G>T	uc002lyy.3	+	4	593	c.163G>T	c.(163-165)GGA>TGA	p.G55*	ATCAY_uc010xhz.1_Nonsense_Mutation_p.G61*	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	55					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		AAATTTCAACGGAGCGCATCG	0.498													1	0	4.35082e-09	0.055883	4.56305e-09	22	23										T	3905458	G	T	3905458	4	4	71	1	0	0	0	0	0	1	0	0	1077	1117	39	4	173	4	ATCAY	19	3905458	Nonsense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	2794715	3905458	55223525	171	22140										
COL5A3	50509	broad.mit.edu	37	chr19	10089574	10089574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	caaagatactcaccgggtccCcagggccccctttggggccg	12	16	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:10089574C>T	uc002mmq.1	-	40	3043	c.2957G>A	c.(2956-2958)GGG>GAG	p.G986E		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	986	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CACCGGGTCCCCAGGGCCCCC	0.622													0	0	0	0.010729	0	11	16										T	10089574	C	T	10089574	3	4	71	1	0	0	0	0	1	0	0	0	3698	623	22	2	2392	2	COL5A3	19	10089574	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	6184116	10089574	49039409	172	22141										
ATG4D	84971	broad.mit.edu	37	chr19	10663675	10663675	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agctcgcccagcccacactcCggctccctcgcacagggcgg	11	20	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:10663675C>T	uc002mov.2	+	10	1477	c.1357C>T	c.(1357-1359)CGG>TGG	p.R453W	ATG4D_uc010xlh.1_Missense_Mutation_p.R390W|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Missense_Mutation_p.R120W	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	453					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GCCCACACTCCGGCTCCCTCG	0.617													0	0	0	0.058154	0	10	83										T	10663675	C	T	10663675	3	4	71	1	0	0	0	0	1	0	0	0	1099	643	23	2	1395	2	ATG4D	19	10663675	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	574101	10663675	48465308	173	22142										
LPHN1	22859	broad.mit.edu	37	chr19	14273534	14273534	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cggaggagatgaactggtagGggttggggaaggtgaggctg	22	3	0	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:14273534G>C	uc010xnn.1	-	6	1390	c.1094C>G	c.(1093-1095)CCC>CGC	p.P365R	LPHN1_uc010xno.1_Missense_Mutation_p.P360R|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	365	Olfactomedin-like.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						GAACTGGTAGGGGTTGGGGAA	0.587													0	0	0	0.008291	0	11	147										C	14273534	G	C	14273534	3	2	71	1	0	0	0	0	1	0	0	0	8915	1232	43	4	3406	4	LPHN1	19	14273534	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	3609859	14273534	44855449	174	22143										
CYP4F2	8529	broad.mit.edu	37	chr19	15990419	15990419	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agaggggccccgcacctcagGgtccggccacacagctgggt	15	15	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:15990419G>A	uc002nbs.1	-	11	1359	c.1309C>T	c.(1309-1311)CCT>TCT	p.P437S	CYP4F2_uc010xot.1_Missense_Mutation_p.P288S	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	437					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CGCACCTCAGGGTCCGGCCAC	0.557													0	0	0	0.048971	0	72	153										A	15990419	G	A	15990419	3	1	71	1	0	0	0	0	1	0	0	0	4188	1232	43	2	265	2	CYP4F2	19	15990419	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	1716885	15990419	43138564	175	22144										
CYP4F11	57834	broad.mit.edu	37	chr19	16035572	16035572	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gtcctaggaaaggactcactCctgacaattgctttcaaagc	8	11	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:16035572C>T	uc002nbu.2	-	6	682	c.646G>A	c.(646-648)GAG>AAG	p.E216K	CYP4F11_uc010eab.1_Missense_Mutation_p.E216K|CYP4F11_uc002nbt.2_Missense_Mutation_p.E216K	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	216					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						AGGACTCACTCCTGACAATTG	0.517													0	0	0	0.047766	0	8	97										T	16035572	C	T	16035572	3	4	71	1	0	0	0	0	1	0	0	0	4186	869	30	1	960	1	CYP4F11	19	16035572	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	45153	16035572	43093411	176	22145										
MLL4	9757	broad.mit.edu	37	chr19	36216719	36216719	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acgcgcaaacggcgccactgGgtgagagatgaggttcaccc	14	12	1	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:36216719G>A	uc010eei.2	+	14	3885	c.3885G>A	c.(3883-3885)TGG>TGA	p.W1295*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1295	PHD-type 2.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCGCCACTGGGTGAGAGATG	0.612													0	0	0	0.021553	0	6	0										A	36216719	G	A	36216719	4	1	71	1	0	0	0	0	0	1	0	0	9623	1246	43	2	3935	2	MLL4	19	36216719	Nonsense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	20181147	36216719	22912264	177	22146										
LILRB2	10288	broad.mit.edu	37	chr19	54782928	54782929	+	Missense_Mutation	DNP	CC	CC	TT													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccaggggccacgacaggacCcggctgcactgagagtgatg					rs141840014		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:54782928_54782929CC>TT	uc002qfb.2	-	6	959_960	c.693_694GG>AA	c.(691-696)CCGGGT>CCAAGT	p.G232S	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.G232S|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.G232S|LILRB2_uc010yet.1_Missense_Mutation_p.G116S|LILRB2_uc010yeu.1_Intron	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	232	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACGACAGGACCCGGCTGCACTG	0.574													0	0	0	0.004672	0	7	133										TT	54782929	CC	TT	54782928	3	4	71	1	0	0	0	0	1	0	0	0	8791	623	22	2	1138	2	LILRB2	19	54782928	Missense_Mutation	DNP	CC	TCGA-E7-A3Y1-01A-11D-A22Z-08	18566209	54782928	4346055	178	22147										
BRSK1	84446	broad.mit.edu	37	chr19	55816212	55816212	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ggcggtggcgtcgggggagcCgcctggaggagtcgtctcaa	20	10	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:55816212C>A	uc002qkg.2	+	14	1918	c.1641C>A	c.(1639-1641)GCC>GCA	p.A547A	BRSK1_uc002qkf.2_Silent_p.A563A|BRSK1_uc002qkh.2_Silent_p.A242A	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	547					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TCGGGGGAGCCGCCTGGAGGA	0.701													1	0	1.836e-18	0.064281	1.98362e-18	37	4										A	55816212	C	A	55816212	2	1	71	1	0	0	0	0	0	0	0	1	1523	639	23	4		4	BRSK1	19	55816212	Silent	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	1033284	55816212	3312771	179	22148										
SSTR4	6754	broad.mit.edu	37	chr20	23016850	23016850	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agatgcgcgccgtggccctgCgcgctggctggcagcagcgc	17	15	0	1	rs4988474	by1000genomes	TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr20:23016850C>T	uc002wsr.2	+	1	794	c.730C>T	c.(730-732)CGC>TGC	p.R244C		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	244	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGTGGCCCTGCGCGCTGGCTG	0.622													0	0	0	0.038147	0	8	157										T	23016850	C	T	23016850	3	4	71	1	0	0	0	0	1	0	0	0	15199	768	27	2	732	2	SSTR4	20	23016850	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		23016850	40008670	180	22149										
CST9	128822	broad.mit.edu	37	chr20	23586272	23586272	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgtccatgctatcctccctcCatgaactcaggacgcgcaac	7	16	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr20:23586272C>T	uc002wtl.2	-	1	339	c.230G>A	c.(229-231)TGG>TAG	p.W77*		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	77						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					ATCCTCCCTCCATGAACTCAG	0.532													0	0	0	0.048971	0	86	127										T	23586272	C	T	23586272	4	4	71	1	0	0	0	0	0	1	0	0	3979	595	21	2	257	2	CST9	20	23586272	Nonsense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	569422	23586272	39439248	181	22150										
PHF20	51230	broad.mit.edu	37	chr20	34501269	34501269	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agaaaaagaaaaccaaacctGgtaattttttttcctgaggg	8	6	0	3			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr20:34501269G>A	uc002xek.1	+	11	1771	c.1660G>A	c.(1660-1662)GAA>AAA	p.E554K	PHF20_uc002xei.1_3'UTR|PHF20_uc010gfo.1_3'UTR|PHF20_uc002xej.1_3'UTR	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					aaCCAAACCTGGTAATTTTTT	0.284													0	0	0	0.010729	0	11	25										A	34501269	G	A	34501269	3	1	71	1	0	0	0	0	1	0	0	0	11831	1362	47	2	1698	2	PHF20	20	34501269	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	10914997	34501269	28524251	182	22151										
TIAM1	7074	broad.mit.edu	37	chr21	32575281	32575281	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	agctgcattttgttttctatTagaaatttcaggcgcaggta	9	6	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr21:32575281T>C	uc002yow.1	-	13	2908	c.2436A>G	c.(2434-2436)CTA>CTG	p.L812L	TIAM1_uc011adk.1_Silent_p.L812L|TIAM1_uc011adl.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	812	RBD.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TGTTTTCTATTAGAAATTTCA	0.388													0	0	0	0.048971	0	81	88										C	32575281	T	C	32575281	2	2	71	1	0	0	0	0	0	0	0	1	15887	1741	61	5		5	TIAM1	21	32575281	Silent	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08		32575281	15554614	183	22152										
KRTAP10-11	386678	broad.mit.edu	37	chr21	46066461	46066461	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cccagagagctgctgtgagcCcccctgcagcgcccccagct	11	19	0	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr21:46066461C>T	uc002zfr.3	+	1	131	c.86C>T	c.(85-87)CCC>CTC	p.P29L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	29	25 X 5 AA repeats of C-C-X(3).|1.					keratin filament				ovary(1)	1						TGCTGTGAGCCCCCCTGCAGC	0.706													0	0	0	0.048971	0	55	71										T	46066461	C	T	46066461	3	4	71	1	0	0	0	0	1	0	0	0	8507	623	22	2	88	2	KRTAP10-11	21	46066461	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	13491180	46066461	2063434	184	22153										
AIFM3	150209	broad.mit.edu	37	chr22	21335037	21335037	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	ctctcttgccttcgtgaaggCtgtttgtgctgcacagcaag	11	11	1	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr22:21335037C>G	uc002ztj.2	+	20	1977	c.1759C>G	c.(1759-1761)CTG>GTG	p.L587V	AIFM3_uc002ztk.2_Intron|AIFM3_uc002ztl.2_Intron|AIFM3_uc011ahx.1_Intron|AIFM3_uc002ztm.1_Intron|LZTR1_uc002ztn.2_Intron|LZTR1_uc002zto.2_5'Flank|LZTR1_uc011ahy.1_5'Flank	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	587					activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TTCGTGAAGGCTGTTTGTGCT	0.522													0	0	0	0.016522	0	21	220										G	21335037	C	G	21335037	3	3	71	1	0	0	0	0	1	0	0	0	428	811	28	4	1851	4	AIFM3	22	21335037	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08		21335037	29969529	185	22154										
AP1B1	162	broad.mit.edu	37	chr22	29750657	29750657	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	accttttctgcacgatgagaTtgatgttgcgcagggccaca	11	10	1	2			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr22:29750657T>C	uc003afj.2	-	7	1104	c.920A>G	c.(919-921)AAT>AGT	p.N307S	AP1B1_uc003afi.2_Missense_Mutation_p.N307S|AP1B1_uc003afk.2_Missense_Mutation_p.N307S|AP1B1_uc003afl.2_Missense_Mutation_p.N307S	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	307					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CACGATGAGATTGATGTTGCG	0.582													0	0	0	0.008291	0	10	94										C	29750657	T	C	29750657	3	2	71	1	0	0	0	0	1	0	0	0	731	1493	52	5	1997	5	AP1B1	22	29750657	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	8415620	29750657	21553909	186	22155										
CHKB	1120	broad.mit.edu	37	chr22	51020239	51020239	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acagctggggccccagcgacCgctccgcaagtatggcgaac	13	15	0	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr22:51020239C>T	uc003bms.2	-	3	604	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Intron|CHKB-CPT1B_uc003bmu.2_Missense_Mutation_p.R8Q|CHKB_uc003bmv.2_Missense_Mutation_p.R129Q|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	129					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	CCCCAGCGACCGCTCCGCAAG	0.617													0	0	0	0.048971	0	49	92										T	51020239	C	T	51020239	3	4	71	1	0	0	0	0	1	0	0	0	3348	652	23	2	837	2	CHKB	22	51020239	Missense_Mutation	SNP	C	TCGA-E7-A3Y1-01A-11D-A22Z-08	21269582	51020239	284327	187	22156										
BMX	660	broad.mit.edu	37	chrX	15552335	15552335	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	aacattctttctgttactagTgataaaaaaggaactgtcaa	6	6	3	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:15552335T>A	uc004cww.2	+	12	1208	c.1020T>A	c.(1018-1020)AAT>AAA	p.N340K	BMX_uc004cwx.3_Missense_Mutation_p.N340K|BMX_uc004cwy.3_Missense_Mutation_p.N340K	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	340	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					CTGTTACTAGTGATAAAAAAG	0.303													0	0	0	0.028581	0	16	54										A	15552335	T	A	15552335	3	1	71	1	0	0	0	0	1	0	0	0	1473	1710	59	5	1062	5	BMX	23	15552335	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08		15552335	139718225	188	22157										
KLHL34	257240	broad.mit.edu	37	chrX	21675187	21675187	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cgggcgggcagcacgaggccAgagcccgagtacacgcgccg	17	15	0	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:21675187A>G	uc004czz.1	-	1	1262	c.720T>C	c.(718-720)TCT>TCC	p.S240S		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	240										ovary(1)	1						GCACGAGGCCAGAGCCCGAGT	0.672													0	0	0	0.021553	0	6	19										G	21675187	A	G	21675187	2	3	71	1	0	0	0	0	0	0	0	1	8387	175	7	5		5	KLHL34	23	21675187	Silent	SNP	A	TCGA-E7-A3Y1-01A-11D-A22Z-08	6122852	21675187	133595373	189	22158										
KLHL15	80311	broad.mit.edu	37	chrX	24024257	24024257	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	acctgctcagatgatcattaTccaagtaagacatgagcttc	7	10	2	4			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:24024257T>C	uc004dba.3	-	3	810	c.554A>G	c.(553-555)GAT>GGT	p.D185G		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	185	BACK.									ovary(1)|breast(1)	2						ATGATCATTATCCAAGTAAGA	0.478													0	0	0	0.048971	0	79	17										C	24024257	T	C	24024257	3	2	71	1	0	0	0	0	1	0	0	0	8371	1435	50	5	1268	5	KLHL15	23	24024257	Missense_Mutation	SNP	T	TCGA-E7-A3Y1-01A-11D-A22Z-08	2349070	24024257	131246303	190	22159										
DDX3X	1654	broad.mit.edu	37	chrX	41205816	41205818	+	In_Frame_Del	DEL	CAA	CAA	-													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	tgttatcaattttgacttgcCaagtgatattgaagaatatg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:41205816_41205818delCAA	uc004dfe.2	+	14	2411_2413	c.1556_1558delCAA	c.(1555-1560)CCAAGT>CGT	p.519_520PS>R	DDX3X_uc004dff.2_In_Frame_Del_p.519_520PS>R|DDX3X_uc011mkq.1_In_Frame_Del_p.503_504PS>R|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	519_520	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TTTGACTTGCCAAGTGATATTGA	0.36										HNSCC(61;0.18)								10	76	---	---								-	41205818	CAA	-	41205816	7	5	71	1	0	1	0	1	0	0	0	0	4358	594	21	0	1610	0	DDX3X	23	41205816	In_Frame_Del	DEL	CAA	TCGA-E7-A3Y1-01A-11D-A22Z-08	17181559	41205816	114064744	191	22160										
UBQLN2	29978	broad.mit.edu	37	chrX	56591910	56591910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	cggctctggtggccccacggGgcctactgtgtccagcgctg	15	15	1	0			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:56591910G>A	uc004dus.2	+	1	1839	c.1604G>A	c.(1603-1605)GGG>GAG	p.G535E	UBQLN2_uc011moq.1_Intron	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	535						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						GGCCCCACGGGGCCTACTGTG	0.622													0	0	0	0.021553	0	5	1										A	56591910	G	A	56591910	3	1	71	1	0	0	0	0	1	0	0	0	16894	1232	43	2	1606	2	UBQLN2	23	56591910	Missense_Mutation	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	15386094	56591910	98678650	192	22161										
PCDH19	57526	broad.mit.edu	37	chrX	99661761	99661762	+	Frame_Shift_Ins	INS	-	-	G													0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gtctatttcaaagaagccgcINSggtcgccctcggtcatgtcg							TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:99661761_99661762insG	uc010nmz.2	-	1	3510_3511	c.1834_1835insC	c.(1834-1836)CGCfs	p.R612fs	PCDH19_uc004efw.3_Frame_Shift_Ins_p.R612fs|PCDH19_uc004efx.3_Frame_Shift_Ins_p.R612fs	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	612	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AAAGAAGCCGCGGTCGCCCTCG	0.564																		42	11	---	---								G	99661762	-	G	99661761	7	5	71	1	0	1	1	0	0	0	0	0	11514	768	27	0	1635	0	PCDH19	23	99661761	Frame_Shift_Ins	INS	-	TCGA-E7-A3Y1-01A-11D-A22Z-08	43069851	99661761	55608799	193	22162										
STAG2	10735	broad.mit.edu	37	chrX	123196751	123196751	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.11340206185567	22	0.0434853750273624	1.48231286418646	3.87422680412371	1.03845254543522	0.400105410870232	0.6266711254594	7	gaagtctttctgttcctttaGgtgcttacagcaaaggagaa	10	7	2	1			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:123196751G>A	uc004etz.3	+	17	1978	c.1639_splice	c.e17-1	p.V547_splice	STAG2_uc004eua.2_Splice_Site_p.V547_splice|STAG2_uc004eub.2_Splice_Site_p.V547_splice|STAG2_uc004euc.2_Splice_Site_p.V547_splice|STAG2_uc004eud.2_Splice_Site_p.V547_splice|STAG2_uc004eue.2_Splice_Site_p.V547_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGTTCCTTTAGGTGCTTACAG	0.343													0	0	0	0.037714	0	29	8										A	123196751	G	A	123196751	5	1	71	1	0	0	0	0	0	0	1	0	15242	1014	35	2	1700	2	STAG2	23	123196751	Splice_Site	SNP	G	TCGA-E7-A3Y1-01A-11D-A22Z-08	23534990	123196751	32073809	194	22163										
CLCN6	1185	broad.mit.edu	37	chr1	11888677	11888677	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgcacccgaaacctaagctcGtcaggtatctgcacagtcgc	9	14	2	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:11888677G>A	uc001ate.3	+	12	1230	c.1117G>A	c.(1117-1119)GTC>ATC	p.V373I	CLCN6_uc009vnh.1_Intron|CLCN6_uc010oat.1_Missense_Mutation_p.V89I|CLCN6_uc010oau.1_Missense_Mutation_p.V351I	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	373	Helical; (By similarity).				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTAAGCTCGTCAGGTATCT	0.627													0	0	0	0.001168	0	6	108										A	11888677	G	A	11888677	3	1	72	1	0	0	0	0	1	0	0	0	3467	1145	40	2	1173	2	CLCN6	1	11888677	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		11888677	237361944	1	22164										
VPS13D	55187	broad.mit.edu	37	chr1	12371682	12371682	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttacaagatccaagaattcaTgtgagtgagaccttatgttc	8	7	1	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:12371682T>C	uc001atv.2	+	28	6963	c.6822T>C	c.(6820-6822)CAT>CAC	p.H2274H	VPS13D_uc001atw.2_Silent_p.H2274H|VPS13D_uc001atx.2_Silent_p.H1462H|VPS13D_uc001aty.1_Silent_p.H12H	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2274					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CAAGAATTCATGTGAGTGAGA	0.433													0	0	0	0.020292	0	14	109										C	12371682	T	C	12371682	2	2	72	1	0	0	0	0	0	0	0	1	17189	1478	51	5		5	VPS13D	1	12371682	Silent	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	483005	12371682	236878939	2	22165										
AADACL4	343066	broad.mit.edu	37	chr1	12704629	12704629	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttttcctgggggtctttgtcTgggctgtctttgagcacttc	12	9	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:12704629T>G	uc001auf.2	+	1	64	c.64T>G	c.(64-66)TGG>GGG	p.W22G		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	22	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		GGTCTTTGTCTGGGCTGTCTT	0.552													0	0	0	0.013537	0	13	124										G	12704629	T	G	12704629	3	3	72	1	0	0	0	0	1	0	0	0	13	1580	55	5	66	5	AADACL4	1	12704629	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	332947	12704629	236545992	3	22166										
MFAP2	4237	broad.mit.edu	37	chr1	17303274	17303274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	actggaactgttcctcggagGgccgaggagtcacctctgca	13	12	2	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:17303274G>A	uc001azw.2	-	5	303	c.170C>T	c.(169-171)CCC>CTC	p.P57L	MFAP2_uc001azx.2_Missense_Mutation_p.P56L|MFAP2_uc001azy.2_Missense_Mutation_p.P57L|MFAP2_uc010ocl.1_Missense_Mutation_p.P56L	NM_002403	NP_002394	P55001	MFAP2_HUMAN	microfibrillar-associated protein 2 isoform a	57						microfibril					0		Colorectal(325;3.46e-05)|Breast(348;0.000118)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000538)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|COAD - Colon adenocarcinoma(227;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;3.04e-05)|Kidney(64;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00544)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		TTCCTCGGAGGGCCGAGGAGT	0.383													0	0	0	0.009096	0	4	89										A	17303274	G	A	17303274	3	1	72	1	0	0	0	0	1	0	0	0	9514	1232	43	2	401	2	MFAP2	1	17303274	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	4598645	17303274	231947347	4	22167										
ARID1A	8289	broad.mit.edu	37	chr1	27057947	27057947	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccagagccagcccccctactCacagccacaggctcagtctc	7	20	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:27057947C>T	uc001bmv.1	+	3	2028	c.1655C>T	c.(1654-1656)TCA>TTA	p.S552L	ARID1A_uc001bmt.1_Missense_Mutation_p.S552L|ARID1A_uc001bmu.1_Missense_Mutation_p.S552L|ARID1A_uc001bmw.1_Missense_Mutation_p.S169L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	552					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCCCCTACTCACAGCCACAG	0.652			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.009535	0	31	203										T	27057947	C	T	27057947	3	4	72	1	0	0	0	0	1	0	0	0	913	838	29	1	1665	1	ARID1A	1	27057947	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	9754673	27057947	222192674	5	22168										
ARID1A	8289	broad.mit.edu	37	chr1	27057988	27057988	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cttaccagcagcagcaacctCagcagccagcaccctcgacg	8	18	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:27057988C>T	uc001bmv.1	+	3	2069	c.1696C>T	c.(1696-1698)CAG>TAG	p.Q566*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q566*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q566*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q183*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	566	Poly-Gln.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAGCAACCTCAGCAGCCAGC	0.637			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.010818	0	32	207										T	27057988	C	T	27057988	4	4	72	1	0	0	0	0	0	1	0	0	913	827	29	1	1706	1	ARID1A	1	27057988	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	41	27057988	222192633	6	22169										
CSMD2	114784	broad.mit.edu	37	chr1	34164482	34164482	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gctccctgcaaaatgaccttCatcatgaaccttgtagccaa	6	13	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:34164482C>T	uc001bxn.1	-	24	3705	c.3676G>A	c.(3676-3678)GAA>AAA	p.E1226K	CSMD2_uc001bxm.1_Missense_Mutation_p.E1266K|CSMD2_uc001bxo.1_Missense_Mutation_p.E139K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1226	Sushi 7.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AAATGACCTTCATCATGAACC	0.537													0	0	0	0.00308	0	7	44										T	34164482	C	T	34164482	3	4	72	1	0	0	0	0	1	0	0	0	3945	835	29	1	6971	1	CSMD2	1	34164482	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	7106494	34164482	215086139	7	22170										
CSMD2	114784	broad.mit.edu	37	chr1	34166205	34166205	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctggatgtgctgttcaaagtCacccccatcatctcagaatg	8	12	4	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:34166205C>T	uc001bxn.1	-	23	3554	c.3525G>A	c.(3523-3525)GTG>GTA	p.V1175V	CSMD2_uc001bxm.1_Silent_p.V1215V|CSMD2_uc001bxo.1_Silent_p.V88V	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1175	Extracellular (Potential).|CUB 7.			V -> E (in Ref. 2; BAC87101).		integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGTTCAAAGTCACCCCCATCA	0.483													0	0	0	0.016723	0	12	85										T	34166205	C	T	34166205	2	4	72	1	0	0	0	0	0	0	0	1	3945	813	29	1		1	CSMD2	1	34166205	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1723	34166205	215084416	8	22171										
ZC3H12A	80149	broad.mit.edu	37	chr1	37947335	37947335	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcctacgagtctgacgggatCgtggtttccaacgacacata	11	11	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:37947335C>T	uc001cbb.3	+	4	867	c.717C>T	c.(715-717)ATC>ATT	p.I239I	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	239					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTGACGGGATCGTGGTTTCCA	0.567													0	0	0	0.013537	0	11	73										T	37947335	C	T	37947335	2	4	72	1	0	0	0	0	0	0	0	1	17558	874	31	1		1	ZC3H12A	1	37947335	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	3781130	37947335	211303286	9	22172										
EPS15	2060	broad.mit.edu	37	chr1	51912718	51912718	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gacacaaatccgtccatatcTttatcagttttcaggaagat	6	9	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:51912718T>C	uc001csq.1	-	10	803	c.711A>G	c.(709-711)AAA>AAG	p.K237K	EPS15_uc009vyz.1_Silent_p.K237K	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	237	EH 3.|EF-hand 2.|2.				cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						CGTCCATATCTTTATCAGTTT	0.363			T	MLL	ALL								0	0	0	0.00308	0	7	67										C	51912718	T	C	51912718	2	2	72	1	0	0	0	0	0	0	0	1	5192	1606	56	5		5	EPS15	1	51912718	Silent	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	13965383	51912718	197337903	10	22173										
GLIS1	148979	broad.mit.edu	37	chr1	54059901	54059901	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aagcaggtgaagtcctcgccCttgcgctggtcgatgtggct	14	11	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:54059901C>G	uc001cvr.1	-	3	1242	c.675G>C	c.(673-675)AAG>AAC	p.K225N		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	225					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						AGTCCTCGCCCTTGCGCTGGT	0.662													0	0	0	0.004672	0	3	20										G	54059901	C	G	54059901	3	3	72	1	0	0	0	0	1	0	0	0	6445	680	24	4	1219	4	GLIS1	1	54059901	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2147183	54059901	195190720	11	22174										
DHCR24	1718	broad.mit.edu	37	chr1	55331117	55331117	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tagtaattgccaatgctattCagctgaaatgacagagggca	10	7	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:55331117C>T	uc001cyc.1	-	6	1008	c.879G>A	c.(877-879)CTG>CTA	p.L293L	DHCR24_uc010ooi.1_5'UTR|DHCR24_uc010ooj.1_Intron|DHCR24_uc010ook.1_Silent_p.L252L	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	293					anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						CAATGCTATTCAGCTGAAATG	0.408													0	0	0	0.006214	0	8	58										T	55331117	C	T	55331117	2	4	72	1	0	0	0	0	0	0	0	1	4476	813	29	1		1	DHCR24	1	55331117	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1271216	55331117	193919504	12	22175										
C1orf173	127254	broad.mit.edu	37	chr1	75036915	75036915	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttcactggaagtgttgccatCgcctgtagactctccggact	10	12	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:75036915C>T	uc001dgg.2	-	14	4698	c.4479G>A	c.(4477-4479)GCG>GCA	p.A1493A		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1493										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGTTGCCATCGCCTGTAGAC	0.522													0	0	0	0.020292	0	13	150										T	75036915	C	T	75036915	2	4	72	1	0	0	0	0	0	0	0	1	2014	871	31	1		1	C1orf173	1	75036915	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	19705798	75036915	174213706	13	22176										
ADAM30	11085	broad.mit.edu	37	chr1	120436733	120436733	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tccagtttttgttttagattCttcctgtacagtttttgttt	6	6	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:120436733C>A	uc001eij.2	-	1	2381	c.2227G>T	c.(2227-2229)GAA>TAA	p.E743*		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	743	2.|5 X 9 AA approximate repeats.|Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GTTTTAGATTCTTCCTGTACA	0.358													1	0	0.00307968	0.00308	0.00322292	8	157										A	120436733	C	A	120436733	4	1	72	1	0	0	0	0	0	1	0	0	248	922	32	3	149	3	ADAM30	1	120436733	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	45399818	120436733	128813888	14	22177										
FLG	2312	broad.mit.edu	37	chr1	152282624	152282624	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgtcttggaccccgctgattCtccctggcccacctgtgagt	10	15	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:152282624C>G	uc001ezu.1	-	3	4774	c.4738G>C	c.(4738-4740)GAA>CAA	p.E1580Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1580	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGCTGATTCTCCCTGGCCC	0.597									Ichthyosis				0	0	0	0.008361	0	31	203										G	152282624	C	G	152282624	3	3	72	1	0	0	0	0	1	0	0	0	5922	922	32	1	7451	1	FLG	1	152282624	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	31845891	152282624	96967997	15	22178										
FLG	2312	broad.mit.edu	37	chr1	152285731	152285731	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atgtggtgtggctgtgatggGaacctgagtgtccagaccta	15	7	0	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:152285731G>A	uc001ezu.1	-	3	1667	c.1631C>T	c.(1630-1632)TCC>TTC	p.S544F	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	544	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTGATGGGAACCTGAGTG	0.557									Ichthyosis				0	0	0	0.00623	0	40	301										A	152285731	G	A	152285731	3	1	72	1	0	0	0	0	1	0	0	0	5922	1174	41	1	10558	1	FLG	1	152285731	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3107	152285731	96964890	16	22179										
SLAMF7	57823	broad.mit.edu	37	chr1	160721190	160721190	+	Frame_Shift_Del	DEL	C	C	-													0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cgggaaactcctaacatatgCccccattctggagagaacac							TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:160721190delC	uc001fwq.2	+	5	840	c.825delC	c.(823-825)TGCfs	p.C275fs	SLAMF7_uc010pjn.1_Frame_Shift_Del_p.C181fs|SLAMF7_uc001fws.2_Frame_Shift_Del_p.C168fs|SLAMF7_uc001fwr.2_Intron|SLAMF7_uc010pjo.1_Frame_Shift_Del_p.C144fs|SLAMF7_uc010pjp.1_Frame_Shift_Del_p.C128fs|SLAMF7_uc010pjq.1_Intron|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	275	Cytoplasmic (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CTAACATATGCCCCCATTCTG	0.468																		11	164	---	---								-	160721190	C	-	160721190	7	5	72	1	0	1	0	1	0	0	0	0	14369	747	26	0	843	0	SLAMF7	1	160721190	Frame_Shift_Del	DEL	C	TCGA-FD-A3B3-01A-12D-A202-08	8435459	160721190	88529431	17	22180										
DARS2	55157	broad.mit.edu	37	chr1	173795890	173795890	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gttcgtctcacttaggccaaGaagtcaccttgtgtggatgg	12	9	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:173795890G>C	uc001gjh.1	+	2	603	c.193G>C	c.(193-195)GAA>CAA	p.E65Q	CENPL_uc009wwg.2_5'Flank|CENPL_uc001gje.3_5'Flank|CENPL_uc001gjg.3_5'Flank|CENPL_uc001gjf.3_5'Flank	NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	65					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	CTTAGGCCAAGAAGTCACCTT	0.398													0	0	0	0.006214	0	7	70										C	173795890	G	C	173795890	3	2	72	1	0	0	0	0	1	0	0	0	4242	943	33	1	199	1	DARS2	1	173795890	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	13074700	173795890	75454731	18	22181										
CR2	1380	broad.mit.edu	37	chr1	207639892	207639892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gatttcttgtggctctcctcCgcctatcctaaatggccgga	9	13	2	0	rs150906379		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:207639892C>T	uc001hfw.2	+	2	174	c.80C>T	c.(79-81)CCG>CTG	p.P27L	CR2_uc001hfv.2_Missense_Mutation_p.P27L|CR2_uc009xch.2_Missense_Mutation_p.P27L	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	27	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GGCTCTCCTCCGCCTATCCTA	0.413													0	0	0	0.016723	0	12	131										T	207639892	C	T	207639892	3	4	72	1	0	0	0	0	1	0	0	0	3842	652	23	2	86	2	CR2	1	207639892	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	33844002	207639892	41610729	19	22182										
MOSC2	54996	broad.mit.edu	37	chr1	220955233	220955233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agttggtgaccctgtgtatcGgatggtgtagtgatgagtga	16	4	0	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:220955233G>A	uc001hmq.2	+	7	1196	c.998G>A	c.(997-999)CGG>CAG	p.R333Q	MOSC2_uc001hmr.2_Missense_Mutation_p.R333Q|MOSC2_uc009xdx.2_Intron	NM_017898	NP_060368	Q969Z3	MOSC2_HUMAN	MOCO sulphurase C-terminal domain containing 2	333	MOSC.					mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.00499)|all cancers(67;0.204)		CCTGTGTATCGGATGGTGTAG	0.438													0	0	0	0.020292	0	11	135										A	220955233	G	A	220955233	3	1	72	1	0	0	0	0	1	0	0	0	9714	1116	39	2	1024	2	MOSC2	1	220955233	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	13315341	220955233	28295388	20	22183										
ZNF692	55657	broad.mit.edu	37	chr1	249144438	249144438	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aggaagcagggttggagcctGaggagatgcagagggcctgg	20	6	0	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr1:249144438G>A	uc001ifc.1	-	12	1698	c.1531C>T	c.(1531-1533)CAG>TAG	p.Q511*	ZNF692_uc001iez.1_Nonsense_Mutation_p.Q233*|ZNF692_uc001ifa.1_Nonsense_Mutation_p.Q233*|ZNF692_uc001ifb.1_Nonsense_Mutation_p.Q307*|ZNF692_uc001ifd.1_Nonsense_Mutation_p.Q510*|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Nonsense_Mutation_p.Q466*|ZNF692_uc010pzr.1_Nonsense_Mutation_p.Q516*	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GTTGGAGCCTGAGGAGATGCA	0.612													0	0	0	0.001984	0	5	51										A	249144438	G	A	249144438	4	1	72	1	0	0	0	0	0	1	0	0	18094	1299	45	1	32	1	ZNF692	1	249144438	Nonsense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	28189205	249144438	106183	21	22184										
MYT1L	23040	broad.mit.edu	37	chr2	1812936	1812936	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtggctctcgggcatcctgaCaagctgtggacaagacacag	13	11	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:1812936C>A	uc002qxe.2	-	22	3911	c.3084G>T	c.(3082-3084)TTG>TTT	p.L1028F	MYT1L_uc002qxd.2_Missense_Mutation_p.L1026F|MYT1L_uc010ewk.2_Missense_Mutation_p.L24F	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1028	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGCATCCTGACAAGCTGTGGA	0.542													1	0	2.74318e-10	0.006214	3.07327e-10	8	79										A	1812936	C	A	1812936	3	1	72	1	0	0	0	0	1	0	0	0	10107	477	17	4	492	4	MYT1L	2	1812936	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08		1812936	241386437	22	22185										
ROCK2	9475	broad.mit.edu	37	chr2	11348013	11348013	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cgcttctgagtttcttgctcTatttttaatgtcaggtttct	7	8	5	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:11348013T>C	uc002rbd.1	-	20	2837	c.2388A>G	c.(2386-2388)ATA>ATG	p.I796M		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	796	Potential.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTTCTTGCTCTATTTTTAATG	0.308													0	0	0	0.001168	0	5	78										C	11348013	T	C	11348013	3	2	72	1	0	0	0	0	1	0	0	0	13518	1512	53	5	1834	5	ROCK2	2	11348013	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	9535077	11348013	231851360	23	22186										
OTOF	9381	broad.mit.edu	37	chr2	26750716	26750716	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttacttgttgctgaagacttTgctgtagttgaaaacctgaa	9	6	0	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:26750716T>C	uc002rhk.2	-	3	338	c.211A>G	c.(211-213)AAA>GAA	p.K71E		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	71	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGAAGACTTTGCTGTAGTTG	0.582													0	0	0	0.00308	0	7	64										C	26750716	T	C	26750716	3	2	72	1	0	0	0	0	1	0	0	0	11303	1821	63	5	6287	5	OTOF	2	26750716	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	15402703	26750716	216448657	24	22187										
RBKS	64080	broad.mit.edu	37	chr2	28081337	28081337	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tggacgtcattgctccaagcCgagcagcttggacacactgg	12	12	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:28081337C>T	uc002rlo.1	-	2	202	c.191G>A	c.(190-192)CGG>CAG	p.R64Q	RBKS_uc010ezi.1_5'UTR|RBKS_uc010ymg.1_Missense_Mutation_p.R64Q	NM_022128	NP_071411	Q9H477	RBSK_HUMAN	ribokinase	64					D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					TGCTCCAAGCCGAGCAGCTTG	0.438													0	0	0	0.009096	0	4	45										T	28081337	C	T	28081337	3	4	72	1	0	0	0	0	1	0	0	0	13108	652	23	2	805	2	RBKS	2	28081337	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1330621	28081337	215118036	25	22188										
STRN	6801	broad.mit.edu	37	chr2	37105140	37105140	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctcccatgatgaatgactttCcagaagaaggaggaaatgtc	10	8	0	5			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:37105140C>G	uc002rpn.2	-	10	1226	c.1217G>C	c.(1216-1218)GGA>GCA	p.G406A	STRN_uc010ezx.2_Missense_Mutation_p.G369A	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	406					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GAATGACTTTCCAGAAGAAGG	0.438													0	0	0	0.013537	0	13	163										G	37105140	C	G	37105140	3	3	72	1	0	0	0	0	1	0	0	0	15328	855	30	1	1161	1	STRN	2	37105140	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	9023803	37105140	206094233	26	22189										
ADRA2B	151	broad.mit.edu	37	chr2	96781355	96781355	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	caaggagcaaagaaagatccGatgctggaggccaggatgta	14	7	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:96781355G>A	uc002svi.2	-	1	534	c.534C>T	c.(532-534)ATC>ATT	p.I178I		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	178	Helical; Name=5; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	AGAAAGATCCGATGCTGGAGG	0.637													0	0	0	0.004672	0	3	32										A	96781355	G	A	96781355	2	1	72	1	0	0	0	0	0	0	0	1	338	1048	37	1		1	ADRA2B	2	96781355	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	59676215	96781355	146418018	27	22190										
GYPC	2995	broad.mit.edu	37	chr2	127447889	127447889	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	catactaccaccattgcaggTgagttctcatcacagagcct	7	13	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:127447889T>A	uc002tnq.2	+	2	262	c.106_splice	c.e2+2	p.E36_splice	GYPC_uc002tnr.2_Intron|GYPC_uc010flv.2_Splice_Site	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1							cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CCATTGCAGGTGAGTTCTCAT	0.527													0	0	0	0.004672	0	3	41										A	127447889	T	A	127447889	5	1	72	1	0	0	0	0	0	0	1	0	6910	1710	59	5	114	5	GYPC	2	127447889	Splice_Site	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	30666534	127447889	115751484	28	22191										
LRP1B	53353	broad.mit.edu	37	chr2	141215109	141215109	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aaatcagtgagagtctgtctGctcccgatgttttatgggca	11	8	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:141215109G>T	uc002tvj.1	-	61	10709	c.9737C>A	c.(9736-9738)GCA>GAA	p.A3246E		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3246	Extracellular (Potential).|LDL-receptor class B 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGTCTGTCTGCTCCCGATGT	0.423										TSP Lung(27;0.18)			1	0	2.17888e-05	0.006214	2.35319e-05	10	74										T	141215109	G	T	141215109	3	4	72	1	0	0	0	0	1	0	0	0	8955	1319	46	4	4186	4	LRP1B	2	141215109	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	13767220	141215109	101984264	29	22192										
RIF1	55183	broad.mit.edu	37	chr2	152321463	152321463	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	taatgatactattaatgattCattaattgtttctgaaacca	4	5	2	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:152321463C>T	uc002txm.2	+	30	5559	c.5429C>T	c.(5428-5430)TCA>TTA	p.S1810L	RIF1_uc002txl.2_Missense_Mutation_p.S1810L|RIF1_uc002txn.2_Missense_Mutation_p.S1810L|RIF1_uc002txo.2_Missense_Mutation_p.S1810L|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1810					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATTAATGATTCATTAATTGTT	0.303													0	0	0	0.004482	0	8	49										T	152321463	C	T	152321463	3	4	72	1	0	0	0	0	1	0	0	0	13359	838	29	1	5543	1	RIF1	2	152321463	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	11106354	152321463	90877910	30	22193										
NEB	4703	broad.mit.edu	37	chr2	152484043	152484043	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcttaattactcacatcgctCtggaggtcataggcctgccg	9	12	4	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:152484043C>G	uc010fnx.2	-	65	9599	c.9408G>C	c.(9406-9408)CAG>CAC	p.Q3136H		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3136	Nebulin 85.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCACATCGCTCTGGAGGTCAT	0.473													0	0	0	0.006214	0	8	138										G	152484043	C	G	152484043	3	3	72	1	0	0	0	0	1	0	0	0	10302	912	32	1	16005	1	NEB	2	152484043	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	162580	152484043	90715330	31	22194										
RAPGEF4	11069	broad.mit.edu	37	chr2	173879313	173879313	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgtatggagacctcctgcaaGaggatgacgtgtctatggcc	13	9	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:173879313G>A	uc002uhv.3	+	18	1967	c.1780G>A	c.(1780-1782)GAG>AAG	p.E594K	RAPGEF4_uc002uhw.3_Missense_Mutation_p.E450K	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	594	N-terminal Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CCTCCTGCAAGAGGATGACGT	0.502													0	0	0	0.014758	0	4	30										A	173879313	G	A	173879313	3	1	72	1	0	0	0	0	1	0	0	0	13046	943	33	1	1866	1	RAPGEF4	2	173879313	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	21395270	173879313	69320060	32	22195										
ZAK	51776	broad.mit.edu	37	chr2	174047626	174047626	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atgattacattaacagtaacAgaagtgaggagatggatatg	11	3	0	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:174047626A>G	uc002uhz.2	+	4	492	c.292A>G	c.(292-294)AGA>GGA	p.R98G	ZAK_uc002uhx.2_Missense_Mutation_p.R98G|ZAK_uc002uhy.2_Missense_Mutation_p.R98G|ZAK_uc010zei.1_5'UTR|ZAK_uc002uia.1_Missense_Mutation_p.R98G	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	98	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)			TAACAGTAACAGAAGTGAGGA	0.323													0	0	0	0.001984	0	6	33										G	174047626	A	G	174047626	3	3	72	1	0	0	0	0	1	0	0	0	17509	180	7	5	302	5	ZAK	2	174047626	Missense_Mutation	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	168313	174047626	69151747	33	22196										
COL5A2	1290	broad.mit.edu	37	chr2	189931119	189931119	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtattatttaaatttaccctTtctcccactggccctggagg	7	11	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:189931119T>C	uc002uqk.2	-	23	1835	c.1560A>G	c.(1558-1560)GAA>GAG	p.E520E	COL5A2_uc010frx.2_Silent_p.E96E	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	520					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AATTTACCCTTTCTCCCACTG	0.453													0	0	0	0.010729	0	11	177										C	189931119	T	C	189931119	2	2	72	1	0	0	0	0	0	0	0	1	3697	1838	64	5		5	COL5A2	2	189931119	Silent	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	15883493	189931119	53268254	34	22197										
TMEFF2	23671	broad.mit.edu	37	chr2	192818461	192818461	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atctgaattgttccaatcacAgctgcgattaagacatactg	7	9	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:192818461A>T	uc002utc.2	-	9	1366	c.972T>A	c.(970-972)GCT>GCA	p.A324A		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	324	Helical; (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			TTCCAATCACAGCTGCGATTA	0.433													0	0	0	0.008291	0	9	46										T	192818461	A	T	192818461	2	4	72	1	0	0	0	0	0	0	0	1	16011	175	7	5		5	TMEFF2	2	192818461	Silent	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	2887342	192818461	50380912	35	22198										
FN1	2335	broad.mit.edu	37	chr2	216259329	216259329	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	actgacattgtactccaggcCgggactcaggttatcaaaag	10	10	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:216259329C>T	uc002vfa.2	-	24	3984	c.3718G>A	c.(3718-3720)GGC>AGC	p.G1240S	FN1_uc002vfb.2_Missense_Mutation_p.G1240S|FN1_uc002vfc.2_Missense_Mutation_p.G1240S|FN1_uc002vfd.2_Missense_Mutation_p.G1240S|FN1_uc002vfe.2_Missense_Mutation_p.G1240S|FN1_uc002vff.2_Missense_Mutation_p.G1240S|FN1_uc002vfg.2_Missense_Mutation_p.G1240S|FN1_uc002vfh.2_Missense_Mutation_p.G1240S|FN1_uc002vfi.2_Missense_Mutation_p.G1240S|FN1_uc002vfj.2_Missense_Mutation_p.G1240S|FN1_uc002vez.2_5'Flank|FN1_uc010zjp.1_5'Flank	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1240	Fibronectin type-III 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACTCCAGGCCGGGACTCAGG	0.453													0	0	0	0.004482	0	7	145										T	216259329	C	T	216259329	3	4	72	1	0	0	0	0	1	0	0	0	5962	652	23	2	3807	2	FN1	2	216259329	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	23440868	216259329	26940044	36	22199										
B3GNT7	93010	broad.mit.edu	37	chr2	232263313	232263313	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgtacggcaaggccagctatCcgccgtatgcaggcggcggt	15	12	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:232263313C>T	uc002vrs.2	+	2	1063	c.883C>T	c.(883-885)CCG>TCG	p.P295S		NM_145236	NP_660279	Q8NFL0	B3GN7_HUMAN	UDP-GlcNAc:betaGal	295	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;3.22e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)		GGCCAGCTATCCGCCGTATGC	0.647													0	0	0	0.009096	0	4	25										T	232263313	C	T	232263313	3	4	72	1	0	0	0	0	1	0	0	0	1262	855	30	1	889	1	B3GNT7	2	232263313	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	16003984	232263313	10936060	37	22200										
INPP5D	3635	broad.mit.edu	37	chr2	234098579	234098579	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcctctgacagcgacgaatcCtatggtaagggtctgtgggc	13	10	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:234098579C>T	uc010zmo.1	+	21	2595	c.2442C>T	c.(2440-2442)TCC>TCT	p.S814S	INPP5D_uc010zmp.1_Silent_p.S813S	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	814					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GCGACGAATCCTATGGTAAGG	0.567													0	0	0	0.014758	0	5	45										T	234098579	C	T	234098579	2	4	72	1	0	0	0	0	0	0	0	1	7756	668	24	2		2	INPP5D	2	234098579	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1835266	234098579	9100794	38	22201										
MTERFD2	130916	broad.mit.edu	37	chr2	242035456	242035456	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	catcctcatcattgtcctccGcctcgtcgtcgtcctcatca	5	18	4	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr2:242035456G>A	uc002wan.1	-	3	1683	c.1190C>T	c.(1189-1191)GCG>GTG	p.A397V	MTERFD2_uc010zoj.1_Missense_Mutation_p.A180V	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	368										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		attgtcctccgcctcgtcgtc	0.194													0	0	0	0.014758	0	5	64										A	242035456	G	A	242035456	3	1	72	1	0	0	0	0	1	0	0	0	9920	1087	38	2	46	2	MTERFD2	2	242035456	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	7936877	242035456	1163917	39	22202										
CADPS	8618	broad.mit.edu	37	chr3	62484936	62484936	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcaggagtgattaaccggccTacattttctgtagtacaaga	10	8	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr3:62484936T>C	uc003dll.2	-	18	2967	c.2607A>G	c.(2605-2607)GTA>GTG	p.V869V	CADPS_uc003dlk.1_Silent_p.V373V|CADPS_uc003dlm.2_Silent_p.V886V|CADPS_uc003dln.2_Silent_p.V846V	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	869	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TTAACCGGCCTACATTTTCTG	0.398													0	0	0	0.014758	0	4	28										C	62484936	T	C	62484936	2	2	72	1	0	0	0	0	0	0	0	1	2570	1509	53	5		5	CADPS	3	62484936	Silent	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08		62484936	135537494	40	22203										
ROBO2	6092	broad.mit.edu	37	chr3	77645844	77645844	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	attcttggccagccacgagcTtgccagtaaataatagcaac	8	11	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr3:77645844T>A	uc003dpy.3	+	19	3440	c.2797T>A	c.(2797-2799)TTG>ATG	p.L933M	ROBO2_uc003dpz.2_Missense_Mutation_p.L937M|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.L937M|ROBO2_uc003dqa.2_Missense_Mutation_p.L60M	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	933	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGCCACGAGCTTGCCAGTAAA	0.428													0	0	0	0.006214	0	8	87										A	77645844	T	A	77645844	3	1	72	1	0	0	0	0	1	0	0	0	13514	1606	56	5	2873	5	ROBO2	3	77645844	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	15160908	77645844	120376586	41	22204										
MYH15	22989	broad.mit.edu	37	chr3	108133162	108133162	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	accatttcagcattgactttGgataaggtccggtgcagctc	10	10	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr3:108133162G>C	uc003dxa.1	-	31	4179	c.4122C>G	c.(4120-4122)TCC>TCG	p.S1374S		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1374	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CATTGACTTTGGATAAGGTCC	0.498													0	0	0	0.006214	0	8	31										C	108133162	G	C	108133162	2	2	72	1	0	0	0	0	0	0	0	1	10034	1335	47	4		4	MYH15	3	108133162	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	30487318	108133162	89889268	42	22205										
TRH	7200	broad.mit.edu	37	chr3	129695896	129695896	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgaaaaacgccagcatccggGcaagagggccctgggaggcc	15	12	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr3:129695896G>T	uc003enc.2	+	3	1127	c.566G>T	c.(565-567)GGC>GTC	p.G189V		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	189					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						CAGCATCCGGGCAAGAGGGCC	0.527													1	0	1.58986e-06	0.008291	1.74497e-06	10	41										T	129695896	G	T	129695896	3	4	72	1	0	0	0	0	1	0	0	0	16475	1203	42	4	572	4	TRH	3	129695896	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	21562734	129695896	68326534	43	22206										
C3orf58	205428	broad.mit.edu	37	chr3	143691456	143691456	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtgaagaacgtgtacttcgcGcagtacggcgagccccgcga	14	12	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr3:143691456G>C	uc003evo.2	+	1	817	c.282G>C	c.(280-282)GCG>GCC	p.A94A	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	94						COPI vesicle coat|extracellular region				ovary(1)	1						TGTACTTCGCGCAGTACGGCG	0.692													0	0	0	0.001168	0	6	52										C	143691456	G	C	143691456	2	2	72	1	0	0	0	0	0	0	0	1	2236	1074	38	4		4	C3orf58	3	143691456	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	13995560	143691456	54330974	44	22207										
PIGG	54872	broad.mit.edu	37	chr4	524484	524484	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccctgagacacgatgcagctGagattactgtgatgcattat	10	9	0	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:524484G>C	uc003gak.3	+	11	2657	c.2521G>C	c.(2521-2523)GAG>CAG	p.E841Q	PIGG_uc003gaj.3_Missense_Mutation_p.E833Q|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.E708Q|PIGG_uc003gal.3_Missense_Mutation_p.E752Q	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	841					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CGATGCAGCTGAGATTACTGT	0.378													0	0	0	0.001984	0	7	172										C	524484	G	C	524484	3	2	72	1	0	0	0	0	1	0	0	0	11888	1291	45	1	2563	1	PIGG	4	524484	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		524484	190629792	45	22208										
KIAA0232	9778	broad.mit.edu	37	chr4	6843914	6843914	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aggctgctgtccagtgtcttCgatctgcttctgatgaagta	11	9	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:6843914C>T	uc003gjr.3	+	4	815	c.352C>T	c.(352-354)CGA>TGA	p.R118*	KIAA0232_uc003gjq.3_Nonsense_Mutation_p.R118*	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	118							ATP binding			ovary(2)	2						CCAGTGTCTTCGATCTGCTTC	0.348													0	0	0	0.009096	0	4	67										T	6843914	C	T	6843914	4	4	72	1	0	0	0	0	0	1	0	0	8163	876	31	1	358	1	KIAA0232	4	6843914	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	6319430	6843914	184310362	46	22209										
CPZ	8532	broad.mit.edu	37	chr4	8616129	8616129	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cacaccaactgctttgagatCacggtagagctgggctgtgt	12	10	1	2	rs139712717	byFrequency	TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:8616129C>T	uc003glm.2	+	9	1533	c.1407C>T	c.(1405-1407)ATC>ATT	p.I469I	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Silent_p.I332I|CPZ_uc003glo.2_Silent_p.I458I|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	469					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCTTTGAGATCACGGTAGAGC	0.582													0	0	0	0.014758	0	5	62										T	8616129	C	T	8616129	2	4	72	1	0	0	0	0	0	0	0	1	3839	816	29	1		1	CPZ	4	8616129	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1772215	8616129	182538147	47	22210										
LRRC66	339977	broad.mit.edu	37	chr4	52861074	52861074	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgaacagagacccctcatcaGagtcacagtcactctccaac	6	15	5	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:52861074G>A	uc003gzi.2	-	4	2127	c.2114C>T	c.(2113-2115)TCT>TTT	p.S705F		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	705						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CCCCTCATCAGAGTCACAGTC	0.527													0	0	0	0.014758	0	4	76										A	52861074	G	A	52861074	3	1	72	1	0	0	0	0	1	0	0	0	9018	942	33	1	532	1	LRRC66	4	52861074	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	44244945	52861074	138293202	48	22211										
PDGFRA	5156	broad.mit.edu	37	chr4	54280809	54280809	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acttcttctcagtctcagacAagtactgcctccagaaaagc	6	13	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:54280809A>C	uc003haa.2	+	11	1029	c.843A>C	c.(841-843)ACA>ACC	p.T281T	FIP1L1_uc003gzx.3_Silent_p.T266T|FIP1L1_uc011bzt.1_Intron|FIP1L1_uc003gzy.2_Silent_p.T281T|FIP1L1_uc011bzu.1_Silent_p.T266T|FIP1L1_uc003gzz.2_Intron|FIP1L1_uc003hab.2_Silent_p.T246T|FIP1L1_uc003hac.2_Intron|FIP1L1_uc010ign.2_Intron	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AGTCTCAGACAAGTACTGCCT	0.403			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.00308	0	6	24										C	54280809	A	C	54280809	2	2	72	1	0	0	0	0	0	0	0	1	11661	117	5	5		5	PDGFRA	4	54280809	Silent	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	1419735	54280809	136873467	49	22212										
KDR	3791	broad.mit.edu	37	chr4	55948801	55948801	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cttactgttctgcagatactGactgcaaaagaacaaatatt	6	8	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:55948801G>A	uc003has.2	-	28	3966	c.3664C>T	c.(3664-3666)CAG>TAG	p.Q1222*	KDR_uc003hat.1_Nonsense_Mutation_p.Q1222*	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1222	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TGCAGATACTGACTGCAAAAG	0.373			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.00308	0	7	54										A	55948801	G	A	55948801	4	1	72	1	0	0	0	0	0	1	0	0	8139	1304	45	1	418	1	KDR	4	55948801	Nonsense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1667992	55948801	135205475	50	22213										
SLC4A4	8671	broad.mit.edu	37	chr4	72215710	72215710	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gccacattgtcccttcatagTttatttgagctgaggacatg	9	9	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:72215710T>G	uc003hfy.2	+	5	588	c.471T>G	c.(469-471)AGT>AGG	p.S157R	SLC4A4_uc010iic.2_Missense_Mutation_p.S157R|SLC4A4_uc010iib.2_Missense_Mutation_p.S157R|SLC4A4_uc003hfz.2_Missense_Mutation_p.S157R|SLC4A4_uc003hgc.3_Missense_Mutation_p.S113R|SLC4A4_uc003hga.2_Missense_Mutation_p.S35R|SLC4A4_uc003hgb.3_Missense_Mutation_p.S113R	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	157	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			CCCTTCATAGTTTATTTGAGC	0.453													0	0	0	0.001168	0	6	82										G	72215710	T	G	72215710	3	3	72	1	0	0	0	0	1	0	0	0	14656	1722	60	5	606	5	SLC4A4	4	72215710	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	16266909	72215710	118938566	51	22214										
ANXA5	308	broad.mit.edu	37	chr4	122591161	122591161	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aggcaggtatacttcgaataGatttcactaagaaaataaac	7	6	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr4:122591161G>C	uc003idu.3	-	10	798	c.728C>G	c.(727-729)TCT>TGT	p.S243C	ANXA5_uc003idv.3_Missense_Mutation_p.S243C|ANXA5_uc003idw.3_RNA|ANXA5_uc010inm.2_Missense_Mutation_p.S243C|ANXA5_uc010inn.2_Missense_Mutation_p.S183C|ANXA5_uc010ino.2_Missense_Mutation_p.S143C	NM_001154	NP_001145	P08758	ANXA5_HUMAN	annexin 5	243					anti-apoptosis|blood coagulation|negative regulation of coagulation|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			ovary(1)	1						ACTTCGAATAGATTTCACTAA	0.333													0	0	0	0.006214	0	8	51										C	122591161	G	C	122591161	3	2	72	1	0	0	0	0	1	0	0	0	721	942	33	1	246	1	ANXA5	4	122591161	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	50375451	122591161	68563115	52	22215										
ADAMTS16	170690	broad.mit.edu	37	chr5	5186206	5186206	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aagacctcttcatcttgccaGatgagtataagtcttgctta	7	9	4	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:5186206G>A	uc003jdl.2	+	5	943	c.805G>A	c.(805-807)GAT>AAT	p.D269N	ADAMTS16_uc003jdk.1_Missense_Mutation_p.D269N|ADAMTS16_uc003jdj.1_Missense_Mutation_p.D269N	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	269					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CATCTTGCCAGATGAGTATAA	0.498													0	0	0	0.01441	0	61	166										A	5186206	G	A	5186206	3	1	72	1	0	0	0	0	1	0	0	0	261	942	33	1	823	1	ADAMTS16	5	5186206	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		5186206	175729054	53	22216										
MTRR	4552	broad.mit.edu	37	chr5	7895909	7895909	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gatgacccctcaatccccatCataatggtgggtccaggaac	9	13	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:7895909C>T	uc003jed.2	+	12	1731	c.1701C>T	c.(1699-1701)ATC>ATT	p.I567I	MTRR_uc003jee.3_Silent_p.I540I|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	567					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	CAATCCCCATCATAATGGTGG	0.398													0	0	0	0.01441	0	52	110										T	7895909	C	T	7895909	2	4	72	1	0	0	0	0	0	0	0	1	9961	816	29	1		1	MTRR	5	7895909	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2709703	7895909	173019351	54	22217										
MTMR12	54545	broad.mit.edu	37	chr5	32229905	32229905	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cacacatcccctaggtccacGaactcatcttctcgtttggc	6	16	3	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:32229905G>A	uc003jhq.2	-	16	2393	c.2223C>T	c.(2221-2223)TTC>TTT	p.F741F	MTMR12_uc010iuk.2_Silent_p.F687F|MTMR12_uc010iul.2_Silent_p.F631F	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	741						cytoplasm	phosphatase activity			ovary(1)	1						CTAGGTCCACGAACTCATCTT	0.512													0	0	0	0.007413	0	18	51										A	32229905	G	A	32229905	2	1	72	1	0	0	0	0	0	0	0	1	9941	1049	37	1		1	MTMR12	5	32229905	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	24333996	32229905	148685355	55	22218										
MTMR12	54545	broad.mit.edu	37	chr5	32230145	32230145	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atcatttccaagagtttgctCagagtggccacttggccacc	9	12	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:32230145C>T	uc003jhq.2	-	16	2153	c.1983G>A	c.(1981-1983)CTG>CTA	p.L661L	MTMR12_uc010iuk.2_Silent_p.L607L|MTMR12_uc010iul.2_Silent_p.L551L	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	661						cytoplasm	phosphatase activity			ovary(1)	1						AGAGTTTGCTCAGAGTGGCCA	0.572													0	0	0	0.008291	0	9	184										T	32230145	C	T	32230145	2	4	72	1	0	0	0	0	0	0	0	1	9941	813	29	1		1	MTMR12	5	32230145	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	240	32230145	148685115	56	22219										
FBXO4	26272	broad.mit.edu	37	chr5	41929974	41929974	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgttgagcttgatgtcttcaGaggaactttgcccaacagct	10	9	2	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:41929974G>A	uc003jmq.2	+	3	657	c.601G>A	c.(601-603)GAG>AAG	p.E201K	FBXO4_uc003jmp.2_Missense_Mutation_p.E201K|FBXO4_uc003jmr.2_Missense_Mutation_p.E201K	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	201					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				GATGTCTTCAGAGGAACTTTG	0.398													0	0	0	0.01441	0	56	170										A	41929974	G	A	41929974	3	1	72	1	0	0	0	0	1	0	0	0	5748	943	33	1	611	1	FBXO4	5	41929974	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	9699829	41929974	138985286	57	22220										
CCNH	902	broad.mit.edu	37	chr5	86700789	86700789	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aagtcatcagctgttttcctCaaaatctctggattctccaa	5	11	5	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:86700789C>G	uc003kjb.2	-	5	793	c.561G>C	c.(559-561)TTG>TTC	p.L187F	CCNH_uc003kiy.1_Intron|CCNH_uc003kiz.1_Missense_Mutation_p.L134F|CCNH_uc003kja.2_Missense_Mutation_p.L134F	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	187					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		CTGTTTTCCTCAAAATCTCTG	0.373								Direct_reversal_of_damage|NER					0	0	0	0.00308	0	5	63										G	86700789	C	G	86700789	3	3	72	1	0	0	0	0	1	0	0	0	2925	825	29	1	430	1	CCNH	5	86700789	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	44770815	86700789	94214471	58	22221										
GPR98	84059	broad.mit.edu	37	chr5	90106693	90106693	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctgctgtgtctgaaaagcctGatgtggccactgtaactgcc	11	11	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:90106693G>A	uc003kju.2	+	74	15712	c.15616G>A	c.(15616-15618)GAT>AAT	p.D5206N	GPR98_uc003kjt.2_Missense_Mutation_p.D2912N|GPR98_uc003kjw.2_Missense_Mutation_p.D867N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5206	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGAAAAGCCTGATGTGGCCAC	0.463													0	0	0	0.001168	0	5	50										A	90106693	G	A	90106693	3	1	72	1	0	0	0	0	1	0	0	0	6721	1290	45	1	15910	1	GPR98	5	90106693	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3405904	90106693	90808567	59	22222										
FER	2241	broad.mit.edu	37	chr5	108516587	108516587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccattaaatggacagcaccgGaagctcttaattatggtaag	9	8	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:108516587G>A	uc003kop.1	+	18	2572	c.2188G>A	c.(2188-2190)GAA>AAA	p.E730K	FER_uc011cvg.1_Missense_Mutation_p.E555K	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	730	Protein kinase.			E -> G (in Ref. 2; BAG61714).	intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GACAGCACCGGAAGCTCTTAA	0.373													0	0	0	0.008291	0	10	52										A	108516587	G	A	108516587	3	1	72	1	0	0	0	0	1	0	0	0	5813	1175	41	1	2250	1	FER	5	108516587	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	18409894	108516587	72398673	60	22223										
WDR36	134430	broad.mit.edu	37	chr5	110462533	110462533	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acccatttgcaatcactcttCaatcaaagcatgtgtatttt	4	10	4	0	rs79307023		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:110462533C>T	uc003kpd.2	+	23	2925	c.2808C>T	c.(2806-2808)TTC>TTT	p.F936F	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	936					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		AATCACTCTTCAATCAAAGCA	0.323													0	0	0	0.014758	0	5	35										T	110462533	C	T	110462533	2	4	72	1	0	0	0	0	0	0	0	1	17287	825	29	1		1	WDR36	5	110462533	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1945946	110462533	70452727	61	22224										
RAD50	10111	broad.mit.edu	37	chr5	131931309	131931309	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tttactcccagttcattactCagctaacagacgaaaaccag	5	12	2	1	rs142947311		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:131931309C>T	uc003kxi.2	+	13	2401	c.2014C>T	c.(2014-2016)CAG>TAG	p.Q672*	RAD50_uc003kxh.2_Nonsense_Mutation_p.Q533*	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	672	Zinc-hook.|Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTTCATTACTCAGCTAACAGA	0.383								Homologous_recombination					0	0	0	0.014758	0	5	46										T	131931309	C	T	131931309	4	4	72	1	0	0	0	0	0	1	0	0	12984	827	29	1	2064	1	RAD50	5	131931309	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	21468776	131931309	48983951	62	22225										
SEC24A	10802	broad.mit.edu	37	chr5	134007548	134007548	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atggtggtccacagtagttaCgacgagattgaaggaggtgg	16	5	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:134007548C>T	uc003kzs.2	+	4	1077	c.789C>T	c.(787-789)TAC>TAT	p.Y263Y	SEC24A_uc011cxu.1_Missense_Mutation_p.T31M	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	263					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAGTAGTTACGACGAGATTG	0.313													0	0	0	0.008291	0	7	46										T	134007548	C	T	134007548	2	4	72	1	0	0	0	0	0	0	0	1	13994	547	19	2		2	SEC24A	5	134007548	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2076239	134007548	46907712	63	22226										
PCDHA2	56146	broad.mit.edu	37	chr5	140175779	140175779	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tactactcgttggtgctggaCagcgccctggaccgcgagag	14	12	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:140175779C>A	uc003lhd.2	+	1	1336	c.1230C>A	c.(1228-1230)GAC>GAA	p.D410E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.D410E|PCDHA2_uc011czy.1_Missense_Mutation_p.D410E	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	410	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGCTGGACAGCGCCCTGG	0.622													1	0	5.03518e-11	0.007413	5.68828e-11	18	147										A	140175779	C	A	140175779	3	1	72	1	0	0	0	0	1	0	0	0	11524	477	17	4	1232	4	PCDHA2	5	140175779	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	6168231	140175779	40739481	64	22227										
PCDHB5	26167	broad.mit.edu	37	chr5	140515575	140515575	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttgctacgcataatcgcggaGatggcagaaaatacccagag	11	9	0	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:140515575G>C	uc003liq.2	+	1	776	c.559G>C	c.(559-561)GAT>CAT	p.D187H		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	187	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAATCGCGGAGATGGCAGAAA	0.517													0	0	0	0.00308	0	8	59										C	140515575	G	C	140515575	3	2	72	1	0	0	0	0	1	0	0	0	11545	942	33	1	561	1	PCDHB5	5	140515575	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	339796	140515575	40399685	65	22228										
HDAC3	8841	broad.mit.edu	37	chr5	141008783	141008783	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccgtatttgtggaaggacacCgtcatgacccggtcagtgag	13	10	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:141008783C>T	uc003llf.2	-	7	633	c.567G>A	c.(565-567)ACG>ACA	p.T189T	HDAC3_uc003lle.1_Silent_p.T132T|HDAC3_uc010jgd.1_Silent_p.T114T|HDAC3_uc010jge.1_RNA	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	189	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	GGAAGGACACCGTCATGACCC	0.443													0	0	0	0.009096	0	4	43										T	141008783	C	T	141008783	2	4	72	1	0	0	0	0	0	0	0	1	7008	639	23	2		2	HDAC3	5	141008783	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	493208	141008783	39906477	66	22229										
GRIA1	2890	broad.mit.edu	37	chr5	153144153	153144153	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aagcagacagaaattgcctaCgggacgctggaagcaggatc	13	9	0	2	rs149931571	byFrequency	TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr5:153144153C>A	uc003lva.3	+	12	2348	c.1983C>A	c.(1981-1983)TAC>TAA	p.Y661*	GRIA1_uc003luy.3_Nonsense_Mutation_p.Y661*|GRIA1_uc003luz.3_Nonsense_Mutation_p.Y566*|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Nonsense_Mutation_p.Y581*|GRIA1_uc011dcx.1_Nonsense_Mutation_p.Y592*|GRIA1_uc011dcy.1_Nonsense_Mutation_p.Y671*|GRIA1_uc011dcz.1_Nonsense_Mutation_p.Y671*	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	661	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AAATTGCCTACGGGACGCTGG	0.502													1	0	0.004672	0.004672	0.00487042	3	34										A	153144153	C	A	153144153	4	1	72	1	0	0	0	0	0	1	0	0	6767	547	19	4	2029	4	GRIA1	5	153144153	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	12135370	153144153	27771107	67	22230										
HIVEP1	3096	broad.mit.edu	37	chr6	12163852	12163852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtgtcgttcacagaactttgGgtactcataggaatacggtc	11	8	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:12163852G>A	uc003nac.2	+	9	7494	c.7315G>A	c.(7315-7317)GGT>AGT	p.G2439S	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2439					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CAGAACTTTGGGTACTCATAG	0.517													0	0	0	0.005443	0	27	72										A	12163852	G	A	12163852	3	1	72	1	0	0	0	0	1	0	0	0	7186	1232	43	2	7345	2	HIVEP1	6	12163852	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		12163852	158951215	68	22231										
HIVEP1	3096	broad.mit.edu	37	chr6	12164328	12164328	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcaaaccaggtcagcaggacCgagtctcctcaggggttacc	12	13	3	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:12164328C>T	uc003nac.2	+	9	7970	c.7791C>T	c.(7789-7791)ACC>ACT	p.T2597T	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2597					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TCAGCAGGACCGAGTCTCCTC	0.542													0	0	0	0.004672	0	3	41										T	12164328	C	T	12164328	2	4	72	1	0	0	0	0	0	0	0	1	7186	639	23	2		2	HIVEP1	6	12164328	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	476	12164328	158950739	69	22232										
ZKSCAN4	387032	broad.mit.edu	37	chr6	28219395	28219395	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	caatagcaccaccacctcctCcccgctctctggatgctgct	6	19	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:28219395C>T	uc003nks.1	-	1	608	c.364G>A	c.(364-366)GAG>AAG	p.E122K	ZKSCAN4_uc011dlb.1_Intron	NM_019110	NP_061983	Q969J2	ZKSC4_HUMAN	zinc finger with KRAB and SCAN domains 4	122	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ACCACCTCCTCCCCGCTCTCT	0.592													0	0	0	0.014758	0	4	37										T	28219395	C	T	28219395	3	4	72	1	0	0	0	0	1	0	0	0	17686	864	30	1	1293	1	ZKSCAN4	6	28219395	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	16055067	28219395	142895672	70	22233										
MDC1	9656	broad.mit.edu	37	chr6	30673284	30673284	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttttcttcccctagtagcctGagaggtgggttcagaggtga	13	8	2	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:30673284G>C	uc003nrg.3	-	10	4116	c.3676C>G	c.(3676-3678)CAG>GAG	p.Q1226E	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.Q833E	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1226	Pro-rich.|Interaction with the PRKDC complex.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTAGTAGCCTGAGAGGTGGGT	0.572								Other_conserved_DNA_damage_response_genes					0	0	0	0.01441	0	51	205										C	30673284	G	C	30673284	3	2	72	1	0	0	0	0	1	0	0	0	9403	1299	45	1	2617	1	MDC1	6	30673284	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	2453889	30673284	140441783	71	22234										
CCHCR1	54535	broad.mit.edu	37	chr6	31122287	31122287	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	attcacctgctcttggtgcaGcctctgaacctcttccagct	7	15	4	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:31122287G>A	uc003nsr.3	-	4	643	c.520C>T	c.(520-522)CTG>TTG	p.L174L	CCHCR1_uc011dne.1_Silent_p.L174L|CCHCR1_uc003nsq.3_Silent_p.L227L|CCHCR1_uc003nsp.3_Silent_p.L263L|CCHCR1_uc010jsk.1_Silent_p.L174L	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	174	Potential.				cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						TCTTGGTGCAGCCTCTGAACC	0.547													0	0	0	0.014323	0	22	474										A	31122287	G	A	31122287	2	1	72	1	0	0	0	0	0	0	0	1	2877	962	34	2		2	CCHCR1	6	31122287	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	449003	31122287	139992780	72	22235										
MICA	4276	broad.mit.edu	37	chr6	31378387	31378387	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tctgtgcagtcagggtttctTgctgaggtacatctggatgg	14	7	4	1	rs78945208		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:31378387T>C	uc003ntk.1	+	2	177	c.138T>C	c.(136-138)CTT>CTC	p.L46L	MICA_uc003rxz.1_5'UTR					RecName: Full=MHC class I polypeptide-related sequence A;          Short=MIC-A; Flags: Precursor;												0		Ovarian(999;0.0253)				CAGGGTTTCTTGCTGAGGTAC	0.532													0	0	0	0.004672	0	3	51										C	31378387	T	C	31378387	2	2	72	1	0	0	0	0	0	0	0	1	9568	1799	63	5		5	MICA	6	31378387	Silent	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	256100	31378387	139736680	73	22236										
APOBEC2	10930	broad.mit.edu	37	chr6	41029212	41029212	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctcggggatacctagaggatGagcatgcggctgcccatgca	14	11	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:41029212G>A	uc003opl.2	+	2	424	c.277G>A	c.(277-279)GAG>AAG	p.E93K	UNC5CL_uc010jxe.1_Intron|APOBEC2_uc010jxf.2_Intron	NM_006789	NP_006780	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	93					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTAGAGGATGAGCATGCGGC	0.577													0	0	0	0.007413	0	20	82										A	41029212	G	A	41029212	3	1	72	1	0	0	0	0	1	0	0	0	788	1291	45	1	283	1	APOBEC2	6	41029212	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	9650825	41029212	130085855	74	22237										
SUPT3H	8464	broad.mit.edu	37	chr6	44797554	44797554	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcacatcacagttgtcacatCagcaggctagaaaagccatc	8	12	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:44797554C>G	uc003oxo.2	-	13	1304	c.986G>C	c.(985-987)TGA>TCA	p.*329S	SUPT3H_uc003oxn.1_Nonstop_Mutation_p.*318S|SUPT3H_uc011dvv.1_Nonstop_Mutation_p.*166S|SUPT3H_uc003oxp.2_Nonstop_Mutation_p.*318S|SUPT3H_uc011dvw.1_Nonstop_Mutation_p.*232S	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	329					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						GTTGTCACATCAGCAGGCTAG	0.368													0	0	0	0.006122	0	17	120										G	44797554	C	G	44797554	4	3	72	1	0	0	0	0	0	0	0	0	15394	837	29	1	4	1	SUPT3H	6	44797554	Nonstop_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	3768342	44797554	126317513	75	22238										
ASCC3	10973	broad.mit.edu	37	chr6	101110370	101110370	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atgatgaatactaaaaccatCtgggaataattctcgtactt	6	7	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:101110370C>G	uc003pqk.2	-	15	2658	c.2329G>C	c.(2329-2331)GAT>CAT	p.D777H	ASCC3_uc011eai.1_Missense_Mutation_p.D679H	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	777	Helicase C-terminal 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CTAAAACCATCTGGGAATAAT	0.358													0	0	0	0.009096	0	4	35										G	101110370	C	G	101110370	3	3	72	1	0	0	0	0	1	0	0	0	1033	913	32	1	4391	1	ASCC3	6	101110370	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	56312816	101110370	70004697	76	22239										
LAMA2	3908	broad.mit.edu	37	chr6	129674484	129674484	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcaagcactggcatgcacgcGagggctgggagtgtgtttgt	17	8	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:129674484G>C	uc003qbn.2	+	32	4804	c.4699G>C	c.(4699-4701)GAG>CAG	p.E1567Q	LAMA2_uc003qbo.2_Missense_Mutation_p.E1567Q	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1567	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCATGCACGCGAGGGCTGGGA	0.537													0	0	0	0.009096	0	4	64										C	129674484	G	C	129674484	3	2	72	1	0	0	0	0	1	0	0	0	8606	1059	37	1	4825	1	LAMA2	6	129674484	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	28564114	129674484	41440583	77	22240										
SNX9	51429	broad.mit.edu	37	chr6	158296183	158296183	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cagcacagctcaggccagttCgtcggctgccagcaacaatc	10	15	1	0	rs140767756		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:158296183C>T	uc003qqv.1	+	4	448	c.275C>T	c.(274-276)TCG>TTG	p.S92L		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	92					cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CAGGCCAGTTCGTCGGCTGCC	0.488													0	0	0	0.001984	0	6	56										T	158296183	C	T	158296183	3	4	72	1	0	0	0	0	1	0	0	0	14909	893	31	1	289	1	SNX9	6	158296183	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	28621699	158296183	12818884	78	22241										
MAP3K4	4216	broad.mit.edu	37	chr6	161455436	161455436	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aacgcatgtcaaccaaacatCagaggaataatgtggggagg	12	7	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:161455436C>T	uc003qtn.2	+	2	440	c.298C>T	c.(298-300)CAG>TAG	p.Q100*	MAP3K4_uc010kkc.1_Nonsense_Mutation_p.Q100*|MAP3K4_uc003qto.2_Nonsense_Mutation_p.Q100*|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	100					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AACCAAACATCAGAGGAATAA	0.448													0	0	0	0.014758	0	5	44										T	161455436	C	T	161455436	4	4	72	1	0	0	0	0	0	1	0	0	9252	827	29	1	304	1	MAP3K4	6	161455436	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	3159253	161455436	9659631	79	22242										
DLL1	28514	broad.mit.edu	37	chr6	170592161	170592161	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cttttgaagttgaacagcccGagtccggcctttttctttca	8	11	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr6:170592161G>A	uc003qxm.2	-	10	2551	c.2081C>T	c.(2080-2082)TCG>TTG	p.S694L		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	694	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TGAACAGCCCGAGTCCGGCCT	0.468													0	0	0	0.012319	0	19	123										A	170592161	G	A	170592161	3	1	72	1	0	0	0	0	1	0	0	0	4566	1059	37	1	98	1	DLL1	6	170592161	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	9136725	170592161	522906	80	22243										
C7orf28A	51622	broad.mit.edu	37	chr7	5944726	5944726	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cttattttttttcccacagtAtttgcaaacgctacatttgc	4	10	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:5944726A>G	uc003spf.2	+	7	614	c.524A>G	c.(523-525)TAT>TGT	p.Y175C		NM_015622	NP_056437	P86791	CCZ1_HUMAN	hypothetical protein LOC51622	175						lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)		TTCCCACAGTATTTGCAAACG	0.333													0	0	0	0.008291	0	11	92										G	5944726	A	G	5944726	3	3	72	1	0	0	0	0	1	0	0	0	2383	463	16	5	550	5	C7orf28A	7	5944726	Missense_Mutation	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08		5944726	153193937	81	22244										
EEPD1	80820	broad.mit.edu	37	chr7	36194706	36194706	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tggaggcacaagggatgggaGgcctgtgctgaggctggcca	19	8	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:36194706G>T	uc003tfa.2	+	2	1413	c.773G>T	c.(772-774)AGG>ATG	p.R258M		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	258					DNA repair		DNA binding				0						AGGGATGGGAGGCCTGTGCTG	0.647													1	0	0.00621372	0.006214	0.00645271	8	23										T	36194706	G	T	36194706	3	4	72	1	0	0	0	0	1	0	0	0	4932	1000	35	4	775	4	EEPD1	7	36194706	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	30249980	36194706	122943957	82	22245										
PKD1L1	168507	broad.mit.edu	37	chr7	47924229	47924229	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcccgatggtattgcttcttGaatgtcactgtaataggctt	9	8	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:47924229G>C	uc003tny.1	-	19	3232	c.3232C>G	c.(3232-3234)CAA>GAA	p.Q1078E		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1078	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ATTGCTTCTTGAATGTCACTG	0.448													0	0	0	0.00308	0	7	34										C	47924229	G	C	47924229	3	2	72	1	0	0	0	0	1	0	0	0	11964	1299	45	1	5473	1	PKD1L1	7	47924229	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	11729523	47924229	111214434	83	22246										
BAZ1B	9031	broad.mit.edu	37	chr7	72856883	72856883	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcatctctggtcacaggctcCctgtggagaagaaccaaatg	10	11	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:72856883C>G	uc003tyc.2	-	19	4440	c.4095G>C	c.(4093-4095)AGG>AGC	p.R1365S		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1365	Bromo.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				TCACAGGCTCCCTGTGGAGAA	0.552													0	0	0	0.00308	0	8	63										G	72856883	C	G	72856883	3	3	72	1	0	0	0	0	1	0	0	0	1330	637	22	4	360	4	BAZ1B	7	72856883	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	24932654	72856883	86281780	84	22247										
CYP3A5	1577	broad.mit.edu	37	chr7	99264653	99264653	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcttcatcctcagctaaagaGatggcacttttcataaatcc	5	11	4	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:99264653G>A	uc003urq.2	-	5	441	c.354C>T	c.(352-354)ATC>ATT	p.I118I	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_5'UTR|CYP3A5_uc003urr.2_Silent_p.I5I|CYP3A5_uc011kiy.1_Silent_p.I108I|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	118					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	CAGCTAAAGAGATGGCACTTT	0.398													0	0	0	0.001984	0	6	45										A	99264653	G	A	99264653	2	1	72	1	0	0	0	0	0	0	0	1	4180	932	33	1		1	CYP3A5	7	99264653	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	26407770	99264653	59874010	85	22248										
MUC17	140453	broad.mit.edu	37	chr7	100682288	100682288	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccacgccagtggccagtcctGaggctagcaccctttcaaca	9	16	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:100682288G>C	uc003uxp.1	+	3	7644	c.7591G>C	c.(7591-7593)GAG>CAG	p.E2531Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2531	Extracellular (Potential).|40.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTCCTGAGGCTAGCAC	0.478													0	0	0	0.01441	0	47	341										C	100682288	G	C	100682288	3	2	72	1	0	0	0	0	1	0	0	0	9974	1291	45	1	7601	1	MUC17	7	100682288	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1417635	100682288	58456375	86	22249										
POT1	25913	broad.mit.edu	37	chr7	124503417	124503417	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tatgtacctttagaagaaatGatgctccgtccacttctgct	7	10	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:124503417G>A	uc003vlm.2	-	8	1134	c.533C>T	c.(532-534)TCA>TTA	p.S178L	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.S47L|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	178					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						TAGAAGAAATGATGCTCCGTC	0.378													0	0	0	0.001984	0	6	63										A	124503417	G	A	124503417	3	1	72	1	0	0	0	0	1	0	0	0	12260	1294	45	1	1419	1	POT1	7	124503417	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	23821129	124503417	34635246	87	22250										
LRRC4	64101	broad.mit.edu	37	chr7	127669984	127669984	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gggagctcaggccatggaagGagccaggcctgatctcaggg	17	10	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:127669984G>C	uc003vmk.2	-	2	847	c.710C>G	c.(709-711)TCC>TGC	p.S237C	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	237	LRR 7.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GCCATGGAAGGAGCCAGGCCT	0.562													0	0	0	0.004482	0	9	42										C	127669984	G	C	127669984	3	2	72	1	0	0	0	0	1	0	0	0	8997	1174	41	1	1255	1	LRRC4	7	127669984	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3166567	127669984	31468679	88	22251										
TNPO3	23534	broad.mit.edu	37	chr7	128641272	128641272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cagcttcatgtaggttagacGaggtcttatcctgttgctgg	12	8	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:128641272G>A	uc003vol.1	-	6	1087	c.713C>T	c.(712-714)TCG>TTG	p.S238L	TNPO3_uc003vom.1_Missense_Mutation_p.S172L|TNPO3_uc010lly.1_Missense_Mutation_p.S238L|TNPO3_uc010llz.1_Missense_Mutation_p.S238L	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	238					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TAGGTTAGACGAGGTCTTATC	0.478													0	0	0	0.016723	0	12	106										A	128641272	G	A	128641272	3	1	72	1	0	0	0	0	1	0	0	0	16334	1059	37	1	2126	1	TNPO3	7	128641272	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	971288	128641272	30497391	89	22252										
SVOPL	136306	broad.mit.edu	37	chr7	138312990	138312990	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcaggggctctggctctcccCtgagtcccccccagtcacca	10	19	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:138312990C>T	uc011kqh.1	-	10	982	c.982G>A	c.(982-984)GGG>AGG	p.G328R	SVOPL_uc003vue.2_Missense_Mutation_p.G176R	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	328						integral to membrane	transmembrane transporter activity				0						TGGCTCTCCCCTGAGTCCCCC	0.567													0	0	0	0.001168	0	6	49										T	138312990	C	T	138312990	3	4	72	1	0	0	0	0	1	0	0	0	15421	681	24	2	520	2	SVOPL	7	138312990	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	9671718	138312990	20825673	90	22253										
EPHB6	2051	broad.mit.edu	37	chr7	142567711	142567711	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggccttactgggacatgagtGagcaggaggtgagcactgac	16	8	0	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:142567711G>A	uc011kst.1	+	17	3386	c.2599G>A	c.(2599-2601)GAG>AAG	p.E867K	EPHB6_uc011ksu.1_Missense_Mutation_p.E867K|EPHB6_uc003wbs.2_Missense_Mutation_p.E575K|EPHB6_uc003wbt.2_Missense_Mutation_p.E341K|EPHB6_uc003wbu.2_Missense_Mutation_p.E575K|EPHB6_uc003wbv.2_Missense_Mutation_p.E251K	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	867	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGACATGAGTGAGCAGGAGGT	0.498													0	0	0	0.001168	0	6	33										A	142567711	G	A	142567711	3	1	72	1	0	0	0	0	1	0	0	0	5178	1291	45	1	2649	1	EPHB6	7	142567711	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	4254721	142567711	16570952	91	22254										
ABP1	26	broad.mit.edu	37	chr7	150558223	150558223	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acggccccaactacgtccagCgctggatccctgaggacagg	12	15	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:150558223C>G	uc003why.1	+	6	6400	c.2182C>G	c.(2182-2184)CGC>GGC	p.R728G	ABP1_uc003whz.1_Missense_Mutation_p.R728G|ABP1_uc003wia.1_Missense_Mutation_p.R747G	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	728					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CTACGTCCAGCGCTGGATCCC	0.532													0	0	0	0.014758	0	5	32										G	150558223	C	G	150558223	3	3	72	1	0	0	0	0	1	0	0	0	98	768	27	4	2196	4	ABP1	7	150558223	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	7990512	150558223	8580440	92	22255										
ASB10	136371	broad.mit.edu	37	chr7	150878047	150878047	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttggggagggcccctggccaGacacggacggcgccatggtt	17	12	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr7:150878047G>A	uc003wjm.1	-	3	1344	c.1218C>T	c.(1216-1218)GTC>GTT	p.V406V	ASB10_uc003wjl.1_Silent_p.V406V|ASB10_uc003wjn.1_Silent_p.V346V	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	361	ANK 7.				intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCTGGCCAGACACGGACGG	0.692													0	0	0	0.009096	0	4	12										A	150878047	G	A	150878047	2	1	72	1	0	0	0	0	0	0	0	1	1014	929	33	1		1	ASB10	7	150878047	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	319824	150878047	8260616	93	22256										
TEX15	56154	broad.mit.edu	37	chr8	30694583	30694583	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgtggtcaacagcccagaagGagatggctgtacttcatatg	12	8	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr8:30694583G>C	uc003xil.2	-	3	8068	c.8068C>G	c.(8068-8070)CCT>GCT	p.P2690A		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2690										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGCCCAGAAGGAGATGGCTGT	0.453													0	0	0	0.004482	0	8	74										C	30694583	G	C	30694583	3	2	72	1	0	0	0	0	1	0	0	0	15776	1174	41	1	309	1	TEX15	8	30694583	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		30694583	115669439	94	22257										
ZNF704	619279	broad.mit.edu	37	chr8	81577165	81577165	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tttctgttcggcttgaatctGggatggggaaagtaggaggt	16	4	2	1	rs145837256		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr8:81577165G>C	uc003yby.1	-	6	1044	c.812C>G	c.(811-813)CCA>CGA	p.P271R		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	271						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			GCTTGAATCTGGGATGGGGAA	0.577													0	0	0	0.014758	0	5	100										C	81577165	G	C	81577165	3	2	72	1	0	0	0	0	1	0	0	0	18104	1348	47	4	442	4	ZNF704	8	81577165	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	50882582	81577165	64786857	95	22258										
MMP16	4325	broad.mit.edu	37	chr8	89130948	89130948	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccatatatcttctggatgccCtgtaaatcatcattaggtag	7	9	4	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr8:89130948C>A	uc003yeb.3	-	5	1134	c.852G>T	c.(850-852)CAG>CAT	p.Q284H	MMP16_uc003yec.2_Missense_Mutation_p.Q284H	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	284	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TCTGGATGCCCTGTAAATCAT	0.403													1	0	0.000673444	0.008291	0.000713058	10	56										A	89130948	C	A	89130948	3	1	72	1	0	0	0	0	1	0	0	0	9655	680	24	4	1151	4	MMP16	8	89130948	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	7553783	89130948	57233074	96	22259										
STK3	6788	broad.mit.edu	37	chr8	99761532	99761532	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttcgtaatctaattatgtctGagacagagccagcgccacag	9	10	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr8:99761532G>C	uc003yip.2	-	4	464	c.323C>G	c.(322-324)TCA>TGA	p.S108*	STK3_uc003yio.2_Nonsense_Mutation_p.S136*|STK3_uc010mbm.1_Nonsense_Mutation_p.S108*	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	108	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		AATTATGTCTGAGACAGAGCC	0.323													0	0	0	0.016723	0	11	61										C	99761532	G	C	99761532	4	2	72	1	0	0	0	0	0	1	0	0	15294	1294	45	1	1184	1	STK3	8	99761532	Nonsense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	10630584	99761532	46602490	97	22260										
FAM135B	51059	broad.mit.edu	37	chr8	139268995	139268995	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aatctacttcactcagtgcgTcttccatctgcaaaagaaac	5	12	5	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr8:139268995T>A	uc003yuy.2	-	5	476	c.305A>T	c.(304-306)GAC>GTC	p.D102V	FAM135B_uc003yux.2_Missense_Mutation_p.D3V|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	102										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACTCAGTGCGTCTTCCATCTG	0.403										HNSCC(54;0.14)			0	0	0	0.009096	0	4	17										A	139268995	T	A	139268995	3	1	72	1	0	0	0	0	1	0	0	0	5449	1667	58	5	3979	5	FAM135B	8	139268995	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	39507463	139268995	7095027	98	22261										
MPDZ	8777	broad.mit.edu	37	chr9	13147624	13147624	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aatggcttccacagcttgttCatggcttgcatctctgaggt	10	10	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:13147624C>T	uc010mia.1	-	25	3721	c.3664G>A	c.(3664-3666)GAA>AAA	p.E1222K	MPDZ_uc010mhx.2_Intron|MPDZ_uc011lmm.1_Missense_Mutation_p.E114K|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.E1222K|MPDZ_uc010mhz.2_Missense_Mutation_p.E1222K|MPDZ_uc011lmn.1_Missense_Mutation_p.E1222K|MPDZ_uc003zlb.3_Missense_Mutation_p.E1222K	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1222	PDZ 7.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACAGCTTGTTCATGGCTTGCA	0.443													0	0	0	0.00308	0	8	62										T	13147624	C	T	13147624	3	4	72	1	0	0	0	0	1	0	0	0	9722	835	29	1	2545	1	MPDZ	9	13147624	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08		13147624	128065807	99	22262										
TOPORS	10210	broad.mit.edu	37	chr9	32544000	32544000	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acggtagcgaaatcgtcgatCaggggtgacaaaagaaccat	12	8	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:32544000C>T	uc003zrb.2	-	3	690	c.523G>A	c.(523-525)GAT>AAT	p.D175N	TOPORS_uc003zrc.2_Missense_Mutation_p.D108N	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	175	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		AATCGTCGATCAGGGGTGACA	0.448													0	0	0	0.008291	0	11	63										T	32544000	C	T	32544000	3	4	72	1	0	0	0	0	1	0	0	0	16367	826	29	1	2618	1	TOPORS	9	32544000	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	19396376	32544000	108669431	100	22263										
FANCC	2176	broad.mit.edu	37	chr9	97897680	97897680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttctcagacaatttctctcaCtggagattagcttttcaaaa	5	9	4	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:97897680C>T	uc004avh.2	-	8	1053	c.791G>A	c.(790-792)AGT>AAT	p.S264N	FANCC_uc004avi.3_Missense_Mutation_p.S264N	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	264					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				ATTTCTCTCACTGGAGATTAG	0.433			D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.006214	0	10	40										T	97897680	C	T	97897680	3	4	72	1	0	0	0	0	1	0	0	0	5664	565	20	2	917	2	FANCC	9	97897680	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	65353680	97897680	43315751	101	22264										
KIAA1529	57653	broad.mit.edu	37	chr9	100082448	100082448	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acagcaaaactcagctgactGagtggcattcttccctcaac	7	13	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:100082448G>C	uc011lut.1	+	23	2442	c.1669G>C	c.(1669-1671)GAG>CAG	p.E557Q	KIAA1529_uc004axe.1_Missense_Mutation_p.E557Q|KIAA1529_uc004axg.1_Missense_Mutation_p.E418Q|KIAA1529_uc011lus.1_Missense_Mutation_p.E375Q|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.E418Q|KIAA1529_uc011luv.1_Missense_Mutation_p.E415Q	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCAGCTGACTGAGTGGCATTC	0.498													0	0	0	0.01441	0	44	157										C	100082448	G	C	100082448	3	2	72	1	0	0	0	0	1	0	0	0	8240	1291	45	1	1723	1	KIAA1529	9	100082448	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	2184768	100082448	41130983	102	22265										
SVEP1	79987	broad.mit.edu	37	chr9	113194246	113194246	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgggacacatgaacatatgtAggatccatctacgttcaggc	10	9	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:113194246A>G	uc010mtz.2	-	32	5639	c.5302T>C	c.(5302-5304)TAC>CAC	p.Y1768H	SVEP1_uc010mty.2_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1768	EGF-like 7; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GAACATATGTAGGATCCATCT	0.378													0	0	0	0.009096	0	4	59										G	113194246	A	G	113194246	3	3	72	1	0	0	0	0	1	0	0	0	15417	420	15	5	5481	5	SVEP1	9	113194246	Missense_Mutation	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	13111798	113194246	28019185	103	22266										
SLC25A25	114789	broad.mit.edu	37	chr9	130868072	130868072	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cactcagatgattcgagaagGaggggccaggtcactctggc	14	10	3	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:130868072G>A	uc004bte.2	+	6	739	c.710G>A	c.(709-711)GGA>GAA	p.G237E	SLC25A25_uc004btb.2_Missense_Mutation_p.G271E|SLC25A25_uc004btc.2_Missense_Mutation_p.G257E|SLC25A25_uc004btd.2_Missense_Mutation_p.G269E|SLC25A25_uc004btf.2_Missense_Mutation_p.G134E	NM_052901	NP_443133	Q6KCM7	SCMC2_HUMAN	solute carrier family 25, member 25 isoform a	237	Solcar 1.|Mitochondrial matrix (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding				0						ATTCGAGAAGGAGGGGCCAGG	0.587													0	0	0	0.003163	0	15	75										A	130868072	G	A	130868072	3	1	72	1	0	0	0	0	1	0	0	0	14488	1174	41	1	1220	1	SLC25A25	9	130868072	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	17673826	130868072	10345359	104	22267										
CARD9	64170	broad.mit.edu	37	chr9	139262242	139262242	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tccttctcctgcaggccccgGgcgtgctgtgcgtgcagctc	13	16	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr9:139262242G>A	uc004chg.3	-	8	1282	c.1116C>T	c.(1114-1116)GCC>GCT	p.A372A	CARD9_uc011mdw.1_Silent_p.A372A|CARD9_uc011mdx.1_Silent_p.A268A	NM_052813	NP_434700	Q9H257	CARD9_HUMAN	caspase recruitment domain protein 9 isoform 1	372	Potential.				positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			pancreas(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		GCAGGCCCCGGGCGTGCTGTG	0.701													0	0	0	0.014758	0	5	21										A	139262242	G	A	139262242	2	1	72	1	0	0	0	0	0	0	0	1	2652	1219	43	2		2	CARD9	9	139262242	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	8394170	139262242	1951189	105	22268										
CUBN	8029	broad.mit.edu	37	chr10	16932503	16932503	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtggctagcagggctttgtcCacctcctcagttcctgccca	10	15	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:16932503C>G	uc001ioo.2	-	55	8674	c.8622G>C	c.(8620-8622)GTG>GTC	p.V2874V	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Silent_p.V230V	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2874	CUB 21.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGGCTTTGTCCACCTCCTCAG	0.498													0	0	0	0.00308	0	6	62										G	16932503	C	G	16932503	2	3	72	1	0	0	0	0	0	0	0	1	4051	581	21	4		4	CUBN	10	16932503	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08		16932503	118602244	106	22269										
CUBN	8029	broad.mit.edu	37	chr10	17087133	17087133	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agctgtggtaatagggcatcGggtagttgggagatatgaac	16	4	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:17087133G>C	uc001ioo.2	-	25	3597	c.3545C>G	c.(3544-3546)CCG>CGG	p.P1182R		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1182	CUB 7.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATAGGGCATCGGGTAGTTGGG	0.493													0	0	0	0.00308	0	7	61										C	17087133	G	C	17087133	3	2	72	1	0	0	0	0	1	0	0	0	4051	1116	39	4	7498	4	CUBN	10	17087133	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	154630	17087133	118447614	107	22270										
PPYR1	5540	broad.mit.edu	37	chr10	47087272	47087272	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tacctggggattgtgctcatCtgggtcattgcctgtgtcct	12	10	3	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:47087272C>A	uc001jee.2	+	3	908	c.489C>A	c.(487-489)ATC>ATA	p.I163I	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.I163I	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	163	Helical; Name=4; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						TTGTGCTCATCTGGGTCATTG	0.587													1	0	0.00116845	0.001168	0.00123234	6	90										A	47087272	C	A	47087272	2	1	72	1	0	0	0	0	0	0	0	1	12416	903	32	3		3	PPYR1	10	47087272	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	30000139	47087272	88447475	108	22271										
PCDH15	65217	broad.mit.edu	37	chr10	55973780	55973781	+	Frame_Shift_Ins	INS	-	-	A													0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctgtcctaggatgcatatggINSaaaaatcgtgggtaatcctc							TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:55973780_55973781insA	uc001jju.1	-	10	1408_1409	c.1013_1014insT	c.(1012-1014)TTCfs	p.F338fs	PCDH15_uc010qhq.1_Frame_Shift_Ins_p.F343fs|PCDH15_uc010qhr.1_Frame_Shift_Ins_p.F338fs|PCDH15_uc010qhs.1_Frame_Shift_Ins_p.F343fs|PCDH15_uc010qht.1_Frame_Shift_Ins_p.F338fs|PCDH15_uc010qhu.1_Frame_Shift_Ins_p.F338fs|PCDH15_uc001jjv.1_Frame_Shift_Ins_p.F316fs|PCDH15_uc010qhv.1_Frame_Shift_Ins_p.F338fs|PCDH15_uc010qhw.1_Frame_Shift_Ins_p.F301fs|PCDH15_uc010qhx.1_Frame_Shift_Ins_p.F338fs|PCDH15_uc010qhy.1_Frame_Shift_Ins_p.F343fs|PCDH15_uc010qhz.1_Frame_Shift_Ins_p.F338fs|PCDH15_uc010qia.1_Frame_Shift_Ins_p.F316fs|PCDH15_uc010qib.1_Frame_Shift_Ins_p.F316fs|PCDH15_uc001jjw.2_Frame_Shift_Ins_p.F338fs	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	338	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GATGCATATGGAAAAATCGTGG	0.366										HNSCC(58;0.16)								8	57	---	---								A	55973781	-	A	55973780	7	5	72	1	0	1	1	0	0	0	0	0	11511	1165	41	0	6593	0	PCDH15	10	55973780	Frame_Shift_Ins	INS	-	TCGA-FD-A3B3-01A-12D-A202-08	8886508	55973780	79560967	109	22272										
KCNMA1	3778	broad.mit.edu	37	chr10	78943241	78943241	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcaccgtgaagaaatccactAcagagttcacttccagccag	8	13	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:78943241A>G	uc001jxn.2	-	5	923	c.746T>C	c.(745-747)GTA>GCA	p.V249A	KCNMA1_uc001jxj.2_Missense_Mutation_p.V249A|KCNMA1_uc001jxk.1_5'UTR|KCNMA1_uc009xrt.1_Missense_Mutation_p.V69A|KCNMA1_uc001jxo.2_Missense_Mutation_p.V249A|KCNMA1_uc001jxm.2_Missense_Mutation_p.V249A|KCNMA1_uc001jxq.2_Missense_Mutation_p.V249A	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	249	Helical; Name=Segment S3; (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	GAAATCCACTACAGAGTTCAC	0.448													0	0	0	0.009096	0	4	33										G	78943241	A	G	78943241	3	3	72	1	0	0	0	0	1	0	0	0	8073	391	14	5	3232	5	KCNMA1	10	78943241	Missense_Mutation	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	22969461	78943241	56591506	110	22273										
HPSE2	60495	broad.mit.edu	37	chr10	100242424	100242424	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gccctcctgcccatagggctGcagcaggtactggtgaacca	12	14	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:100242424G>A	uc001kpn.1	-	11	1642	c.1582C>T	c.(1582-1584)CAG>TAG	p.Q528*	HPSE2_uc009xwc.1_Nonsense_Mutation_p.Q518*|HPSE2_uc001kpo.1_Nonsense_Mutation_p.Q460*|HPSE2_uc009xwd.1_Nonsense_Mutation_p.Q406*	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	528					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		CCATAGGGCTGCAGCAGGTAC	0.522													0	0	0	0.008361	0	28	160										A	100242424	G	A	100242424	4	1	72	1	0	0	0	0	0	1	0	0	7345	1328	46	2	242	2	HPSE2	10	100242424	Nonsense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	21299183	100242424	35292323	111	22274										
C10orf2	56652	broad.mit.edu	37	chr10	102748960	102748960	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctgaaccccaaacgatgcttCttggtgcgaccaggagacca	10	13	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:102748960C>G	uc001ksf.2	+	1	1668	c.993C>G	c.(991-993)TTC>TTG	p.F331L	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Missense_Mutation_p.F331L|C10orf2_uc001ksi.2_Intron|C10orf2_uc010qpv.1_Intron|C10orf2_uc001ksh.2_Intron	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	331					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AACGATGCTTCTTGGTGCGAC	0.572													0	0	0	0.020292	0	13	67										G	102748960	C	G	102748960	3	3	72	1	0	0	0	0	1	0	0	0	1597	912	32	1	995	1	C10orf2	10	102748960	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2506536	102748960	32785787	112	22275										
HABP2	3026	broad.mit.edu	37	chr10	115337829	115337829	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cctgccagaatggggctaccTgctcccggcataagcggaga	13	13	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:115337829T>A	uc001lai.3	+	6	596	c.493T>A	c.(493-495)TGC>AGC	p.C165S	HABP2_uc010qrz.1_RNA|HABP2_uc010qry.1_Silent_p.P153P	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	165	EGF-like 3.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		TGGGGCTACCTGCTCCCGGCA	0.557													0	0	0	0.006214	0	10	68										A	115337829	T	A	115337829	3	1	72	1	0	0	0	0	1	0	0	0	6938	1580	55	5	515	5	HABP2	10	115337829	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	12588869	115337829	20196918	113	22276										
GPR123	84435	broad.mit.edu	37	chr10	134912196	134912196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cgctcctgaatttctgcttcCacgcggccctgaccttcact	7	17	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr10:134912196C>T	uc001llx.3	+	4	620	c.184C>T	c.(184-186)CAC>TAC	p.H62Y	GPR123_uc001llw.2_Missense_Mutation_p.H782Y	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	62	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TTTCTGCTTCCACGCGGCCCT	0.652													0	0	0	0.004482	0	9	61										T	134912196	C	T	134912196	3	4	72	1	0	0	0	0	1	0	0	0	6637	594	21	2	194	2	GPR123	10	134912196	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	19574367	134912196	622551	114	22277										
ZNF214	7761	broad.mit.edu	37	chr11	7021340	7021340	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cacaatcatgacatttatagGgcttttctcctgtatggact	7	9	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:7021340G>A	uc001mfa.2	-	3	1877	c.1574C>T	c.(1573-1575)CCC>CTC	p.P525L	ZNF214_uc010ray.1_Missense_Mutation_p.P525L|ZNF214_uc009yfh.1_Missense_Mutation_p.P525L	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		ACATTTATAGGGCTTTTCTCC	0.423													0	0	0	0.00308	0	8	67										A	7021340	G	A	7021340	3	1	72	1	0	0	0	0	1	0	0	0	17767	1232	43	2	250	2	ZNF214	11	7021340	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		7021340	127985176	115	22278										
TMEM41B	440026	broad.mit.edu	37	chr11	9305135	9305135	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggctacaaaagaaggaggtgCgacacctgaaataaaatata	10	6	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:9305135C>T	uc001mhm.2	-	7	1020	c.712G>A	c.(712-714)GCA>ACA	p.A238T	TMEM41B_uc001mhn.1_Missense_Mutation_p.A238T	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	238	Helical; (Potential).					integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)		GAAGGAGGTGCGACACCTGAA	0.333													0	0	0	0.001984	0	6	29										T	9305135	C	T	9305135	3	4	72	1	0	0	0	0	1	0	0	0	16162	768	27	2	167	2	TMEM41B	11	9305135	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2283795	9305135	125701381	116	22279										
OR5AS1	219447	broad.mit.edu	37	chr11	55798793	55798793	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aaacaaggatgtgaaaaatgCtctcaaaaagctattagaaa	7	5	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:55798793C>T	uc010riw.1	+	1	899	c.899C>T	c.(898-900)GCT>GTT	p.A300V		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					GTGAAAAATGCTCTCAAAAAG	0.308													0	0	0	0.00308	0	8	32										T	55798793	C	T	55798793	3	4	72	1	0	0	0	0	1	0	0	0	11146	797	28	2	901	2	OR5AS1	11	55798793	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	46493658	55798793	79207723	117	22280										
OR8K5	219453	broad.mit.edu	37	chr11	55927583	55927583	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aatgacagtagaattaccaaGatcaacaaaagccaaatgtc	6	8	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:55927583G>C	uc010rja.1	-	1	211	c.211C>G	c.(211-213)CTT>GTT	p.L71V		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GAATTACCAAGATCAACAAAA	0.403													0	0	0	0.010729	0	12	115										C	55927583	G	C	55927583	3	2	72	1	0	0	0	0	1	0	0	0	11245	942	33	1	715	1	OR8K5	11	55927583	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	128790	55927583	79078933	118	22281										
P2RX3	5024	broad.mit.edu	37	chr11	57135555	57135555	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aaggcttttggcatccgcttCgacgtgctggtatacgggaa	13	9	0	0	rs150261482		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:57135555C>T	uc001nju.2	+	9	991	c.915C>T	c.(913-915)TTC>TTT	p.F305F		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	305	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GCATCCGCTTCGACGTGCTGG	0.567													0	0	0	0.014758	0	4	44										T	57135555	C	T	57135555	2	4	72	1	0	0	0	0	0	0	0	1	11341	883	31	1		1	P2RX3	11	57135555	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1207972	57135555	77870961	119	22282										
AHNAK	79026	broad.mit.edu	37	chr11	62288917	62288917	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cctttgaatcctggcatgctGaatttgggcattttcacctt	8	10	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:62288917G>A	uc001ntl.2	-	5	13272	c.12972C>T	c.(12970-12972)TTC>TTT	p.F4324F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4324					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTGGCATGCTGAATTTGGGCA	0.517													0	0	0	0.001984	0	7	222										A	62288917	G	A	62288917	2	1	72	1	0	0	0	0	0	0	0	1	414	1281	45	1		1	AHNAK	11	62288917	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	5153362	62288917	72717599	120	22283			1	100		3	3	1810	G		7.895044e-05
AHNAK	79026	broad.mit.edu	37	chr11	62289517	62289517	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atagagatcttcggtgccttGaggtgcaggtcaggcatttt	13	7	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:62289517G>A	uc001ntl.2	-	5	12672	c.12372C>T	c.(12370-12372)CTC>CTT	p.L4124L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4124					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCGGTGCCTTGAGGTGCAGGT	0.493													0	0	0	0.001168	0	6	141										A	62289517	G	A	62289517	2	1	72	1	0	0	0	0	0	0	0	1	414	1277	45	1		1	AHNAK	11	62289517	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	600	62289517	72716999	121	22284			1	100		3	3	1810	G		7.895044e-05
AHNAK	79026	broad.mit.edu	37	chr11	62290726	62290726	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aatttaccctctgagccttcGatgttaatgtcaggagtgtc	9	9	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:62290726G>C	uc001ntl.2	-	5	11463	c.11163C>G	c.(11161-11163)ATC>ATG	p.I3721M	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3721					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTGAGCCTTCGATGTTAATGT	0.458													0	0	0	0.006214	0	9	153										C	62290726	G	C	62290726	3	2	72	1	0	0	0	0	1	0	0	0	414	1048	37	1	6629	1	AHNAK	11	62290726	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1209	62290726	72715790	122	22285			1	100		3	3	1810	G		7.895044e-05
RARRES3	5920	broad.mit.edu	37	chr11	63312303	63312303	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gatgaagtacagtattgtgaGcaggaactgtgagcactttg	13	5	0	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:63312303G>T	uc001nxf.3	+	3	397	c.329G>T	c.(328-330)AGC>ATC	p.S110I		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	110					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						AGTATTGTGAGCAGGAACTGT	0.512													1	0	0.000442599	0.006214	0.00047048	9	132										T	63312303	G	T	63312303	3	4	72	1	0	0	0	0	1	0	0	0	13057	971	34	4	339	4	RARRES3	11	63312303	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1021577	63312303	71694213	123	22286										
PACS1	55690	broad.mit.edu	37	chr11	65977851	65977851	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agggttcaaaaagaattcttCgctccaacgagatcgtcctt	8	10	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:65977851C>T	uc001oha.1	+	3	597	c.463C>T	c.(463-465)CGC>TGC	p.R155C	PACS1_uc001ogz.1_Missense_Mutation_p.R155C	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	155					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						AAGAATTCTTCGCTCCAACGA	0.328													0	0	0	0.020292	0	14	56										T	65977851	C	T	65977851	3	4	72	1	0	0	0	0	1	0	0	0	11372	884	31	1	473	1	PACS1	11	65977851	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2665548	65977851	69028665	124	22287										
SUV420H1	51111	broad.mit.edu	37	chr11	67926270	67926270	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aggattctgtctgtgttctcTcgccgcgtgtctagtcaagc	11	11	5	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:67926270T>C	uc001onm.1	-	11	1799	c.1543A>G	c.(1543-1545)AGA>GGA	p.R515G	SUV420H1_uc009yse.1_Missense_Mutation_p.R101G|SUV420H1_uc001onn.1_Missense_Mutation_p.R343G|SUV420H1_uc009ysf.2_Missense_Mutation_p.R275G	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	515					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CTGTGTTCTCTCGCCGCGTGT	0.522													0	0	0	0.009096	0	4	59										C	67926270	T	C	67926270	3	2	72	1	0	0	0	0	1	0	0	0	15411	1559	54	5	1118	5	SUV420H1	11	67926270	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	1948419	67926270	67080246	125	22288										
USP35	57558	broad.mit.edu	37	chr11	77911809	77911809	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cactgcatggtgttccggttCccgggcttcccggatctgta	12	13	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:77911809C>T	uc009yva.1	+	6	1398	c.1152C>T	c.(1150-1152)TTC>TTT	p.F384F	USP35_uc001oze.2_Silent_p.F140F|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_5'UTR|USP35_uc001ozf.2_Silent_p.F115F	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	384					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			TGTTCCGGTTCCCGGGCTTCC	0.622													0	0	0	0.001984	0	4	34										T	77911809	C	T	77911809	2	4	72	1	0	0	0	0	0	0	0	1	17063	854	30	1		1	USP35	11	77911809	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	9985539	77911809	57094707	126	22289										
CARD17	440068	broad.mit.edu	37	chr11	104971361	104971361	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agcaaagctcgggccttatcCataactgtagcattttcaca	7	11	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:104971361C>T	uc001pir.1	-	2	170	c.153G>A	c.(151-153)ATG>ATA	p.M51I	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron	NM_001007232	NP_001007233	Q5XLA6	CAR17_HUMAN	caspase recruitment domain family, member 17	51	CARD.				proteolysis|regulation of apoptosis	cytoplasm	cysteine-type endopeptidase activity|cysteine-type endopeptidase inhibitor activity			ovary(1)	1						GGGCCTTATCCATAACTGTAG	0.443													0	0	0	0.004007	0	16	84										T	104971361	C	T	104971361	3	4	72	1	0	0	0	0	1	0	0	0	2648	594	21	2	187	2	CARD17	11	104971361	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	27059552	104971361	30035155	127	22290										
FOXRED1	55572	broad.mit.edu	37	chr11	126147526	126147526	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccagaccatcgacctgagccCcttcctctttacccgctttt	5	18	1	2	rs142489681		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:126147526C>T	uc001qdi.2	+	11	1450	c.1403C>T	c.(1402-1404)CCC>CTC	p.P468L	FOXRED1_uc010sbn.1_Missense_Mutation_p.P298L|FOXRED1_uc010sbo.1_RNA|FOXRED1_uc010sbp.1_Missense_Mutation_p.P281L|FOXRED1_uc010sbq.1_Missense_Mutation_p.P335L|FOXRED1_uc001qdj.2_Missense_Mutation_p.P257L|FOXRED1_uc010sbr.1_Missense_Mutation_p.P454L|FOXRED1_uc001qdk.2_Missense_Mutation_p.P257L	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	468						integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)		GACCTGAGCCCCTTCCTCTTT	0.572													0	0	0	0.014758	0	4	40										T	126147526	C	T	126147526	3	4	72	1	0	0	0	0	1	0	0	0	6033	623	22	2	1445	2	FOXRED1	11	126147526	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	21176165	126147526	8858990	128	22291										
OPCML	4978	broad.mit.edu	37	chr11	132306105	132306105	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgcggcctttgttttcaatcCtcattccatccagaccagtg	7	13	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:132306105C>T	uc001qgs.2	-	6	862	c.812G>A	c.(811-813)AGG>AAG	p.R271K	OPCML_uc001qgu.2_Missense_Mutation_p.R264K|OPCML_uc010sck.1_Missense_Mutation_p.R271K|OPCML_uc001qgt.2_Missense_Mutation_p.R270K|OPCML_uc010scl.1_Missense_Mutation_p.R230K	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	271	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GTTTTCAATCCTCATTCCATC	0.448													0	0	0	0.009096	0	4	109										T	132306105	C	T	132306105	3	4	72	1	0	0	0	0	1	0	0	0	10874	681	24	2	233	2	OPCML	11	132306105	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	6158579	132306105	2700411	129	22292										
NCAPD3	23310	broad.mit.edu	37	chr11	134029834	134029834	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tccagccgtcccggccacatCtgcatgttttgctagctcct	8	16	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr11:134029834C>G	uc001qhd.1	-	29	4426	c.3820G>C	c.(3820-3822)GAT>CAT	p.D1274H	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA|NCAPD3_uc001qhc.1_Missense_Mutation_p.D224H	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	1274	Potential.				cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CCGGCCACATCTGCATGTTTT	0.562													0	0	0	0.014758	0	5	23										G	134029834	C	G	134029834	3	3	72	1	0	0	0	0	1	0	0	0	10206	913	32	1	704	1	NCAPD3	11	134029834	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1723729	134029834	976682	130	22293										
VWF	7450	broad.mit.edu	37	chr12	6085359	6085359	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	catcctccatgtcggtgcagGtgcacacatcgcagccctcc	9	17	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:6085359G>C	uc001qnn.1	-	43	7605	c.7355C>G	c.(7354-7356)ACC>AGC	p.T2452S	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2452	VWFC 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GTCGGTGCAGGTGCACACATC	0.607													0	0	0	0.009096	0	4	89										C	6085359	G	C	6085359	3	2	72	1	0	0	0	0	1	0	0	0	17243	1261	44	4	1126	4	VWF	12	6085359	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		6085359	127766536	131	22294										
CD9	928	broad.mit.edu	37	chr12	6344475	6344475	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gagccccagcgggaaacgctGaaagccatccactatgcggt	12	13	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:6344475G>A	uc001qnp.1	+	6	873	c.429G>A	c.(427-429)CTG>CTA	p.L143L	CD9_uc010sev.1_Silent_p.L143L|CD9_uc001qnq.1_Silent_p.L143L	NM_001769	NP_001760	P21926	CD9_HUMAN	CD9 antigen	143	Extracellular (Potential).				cell adhesion|cellular component movement|fusion of sperm to egg plasma membrane|paranodal junction assembly|platelet activation|platelet degranulation	integral to plasma membrane|platelet alpha granule membrane				ovary(1)	1						GGGAAACGCTGAAAGCCATCC	0.532													0	0	0	0.009096	0	4	64										A	6344475	G	A	6344475	2	1	72	1	0	0	0	0	0	0	0	1	3046	1277	45	1		1	CD9	12	6344475	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	259116	6344475	127507420	132	22295										
PDZRN4	29951	broad.mit.edu	37	chr12	41966808	41966808	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctagtgcttacaacacagctGagagctgcagaagtactccg	10	11	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:41966808G>C	uc010skn.1	+	10	1698	c.1630G>C	c.(1630-1632)GAG>CAG	p.E544Q	PDZRN4_uc001rmq.3_Missense_Mutation_p.E485Q|PDZRN4_uc009zjz.2_Missense_Mutation_p.E483Q|PDZRN4_uc001rmr.2_Missense_Mutation_p.E370Q	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	743							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CAACACAGCTGAGAGCTGCAG	0.458													0	0	0	0.006214	0	9	60										C	41966808	G	C	41966808	3	2	72	1	0	0	0	0	1	0	0	0	11710	1291	45	1	2338	1	PDZRN4	12	41966808	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	35622333	41966808	91885087	133	22296										
STAC3	246329	broad.mit.edu	37	chr12	57638099	57638099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccctagccatttctctcaccCgccaccattcttcattggag	5	17	4	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:57638099C>T	uc001snp.2	-	10	1052	c.857G>A	c.(856-858)CGG>CAG	p.R286Q	STAC3_uc009zpl.2_Silent_p.A3A|STAC3_uc001snq.2_Missense_Mutation_p.R247Q|STAC3_uc010srm.1_Missense_Mutation_p.R100Q	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	286	SH3 1.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TTCTCTCACCCGCCACCATTC	0.552											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014758	0	5	75										T	57638099	C	T	57638099	3	4	72	1	0	0	0	0	1	0	0	0	15240	666	23	2	249	2	STAC3	12	57638099	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	15671291	57638099	76213796	134	22297										
STAC3	246329	broad.mit.edu	37	chr12	57638949	57638949	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atcctggggtttgccttcctCtggtctggccgactctggct	12	13	3	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:57638949C>G	uc001snp.2	-	7	844	c.649G>C	c.(649-651)GAG>CAG	p.E217Q	STAC3_uc009zpl.2_Intron|STAC3_uc001snq.2_Missense_Mutation_p.E178Q|STAC3_uc010srm.1_Missense_Mutation_p.E31Q	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	217					intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TTGCCTTCCTCTGGTCTGGCC	0.592													0	0	0	0.016723	0	12	117										G	57638949	C	G	57638949	3	3	72	1	0	0	0	0	1	0	0	0	15240	922	32	1	469	1	STAC3	12	57638949	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	850	57638949	76212946	135	22298										
R3HDM2	22864	broad.mit.edu	37	chr12	57648809	57648809	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gccactggatcttggcgccaGacatggcgagctgcgtgaag	15	11	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:57648809G>C	uc009zpm.1	-	22	2713	c.2678C>G	c.(2677-2679)TCT>TGT	p.S893C	R3HDM2_uc010srn.1_Intron|R3HDM2_uc001snu.2_Missense_Mutation_p.S588C|R3HDM2_uc001snr.2_Missense_Mutation_p.S620C|R3HDM2_uc001sns.2_Missense_Mutation_p.S893C|R3HDM2_uc001snt.2_Missense_Mutation_p.S907C|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	893						nucleus	nucleic acid binding			ovary(2)	2						CTTGGCGCCAGACATGGCGAG	0.647													0	0	0	0.001984	0	5	70										C	57648809	G	C	57648809	3	2	72	1	0	0	0	0	1	0	0	0	12888	942	33	1	256	1	R3HDM2	12	57648809	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	9860	57648809	76203086	136	22299										
EID3	493861	broad.mit.edu	37	chr12	104697894	104697894	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccgggaggacatcgtgagctCggcgaacaactccttaaccg	12	13	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:104697894C>T	uc001tkw.2	+	1	346	c.182C>T	c.(181-183)TCG>TTG	p.S61L	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						ATCGTGAGCTCGGCGAACAAC	0.612													0	0	0	0.014758	0	5	50										T	104697894	C	T	104697894	3	4	72	1	0	0	0	0	1	0	0	0	4989	893	31	1	184	1	EID3	12	104697894	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	47049085	104697894	29154001	137	22300										
NUAK1	9891	broad.mit.edu	37	chr12	106460646	106460646	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtcacatcatccatgtctgtGaggagggagaagctgctgtc	13	9	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:106460646G>A	uc001tlj.1	-	7	3300	c.1920C>T	c.(1918-1920)CTC>CTT	p.L640L		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	640							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						CCATGTCTGTGAGGAGGGAGA	0.627													0	0	0	0.001984	0	6	96										A	106460646	G	A	106460646	2	1	72	1	0	0	0	0	0	0	0	1	10712	1277	45	1		1	NUAK1	12	106460646	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1762752	106460646	27391249	138	22301										
TRPV4	59341	broad.mit.edu	37	chr12	110230175	110230175	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acccagagctcacctgaagcGtagccgatcatgaagagcaa	10	12	2	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:110230175G>A	uc001tpj.1	-	11	1979	c.1884C>T	c.(1882-1884)TAC>TAT	p.Y628Y	TRPV4_uc001tpg.1_Silent_p.Y594Y|TRPV4_uc001tph.1_Silent_p.Y581Y|TRPV4_uc001tpi.1_Silent_p.Y521Y|TRPV4_uc001tpk.1_Silent_p.Y628Y|TRPV4_uc001tpl.1_Silent_p.Y568Y	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	628	Helical; (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CACCTGAAGCGTAGCCGATCA	0.537													0	0	0	0.014758	0	5	27										A	110230175	G	A	110230175	2	1	72	1	0	0	0	0	0	0	0	1	16595	1140	40	2		2	TRPV4	12	110230175	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3769529	110230175	23621720	139	22302										
DTX1	1840	broad.mit.edu	37	chr12	113515265	113515265	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcggcgcaacttctacgaccCgtcgtcggcgccgggcaagg	15	15	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:113515265C>G	uc001tuk.1	+	2	632	c.296C>G	c.(295-297)CCG>CGG	p.P99R		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	99	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						TTCTACGACCCGTCGTCGGCG	0.667													0	0	0	0.009096	0	4	54										G	113515265	C	G	113515265	3	3	72	1	0	0	0	0	1	0	0	0	4793	652	23	4	302	4	DTX1	12	113515265	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	3285090	113515265	20336630	140	22303										
MPHOSPH9	10198	broad.mit.edu	37	chr12	123706297	123706297	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	attcaggataatggataacaGattcatttctctcactgctt	6	8	4	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr12:123706297G>A	uc001uel.2	-	1	145	c.38C>T	c.(37-39)TCT>TTT	p.S13F	MPHOSPH9_uc010tal.1_5'UTR|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_5'UTR	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	13					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		ATGGATAACAGATTCATTTCT	0.398													0	0	0	0.014758	0	5	80										A	123706297	G	A	123706297	3	1	72	1	0	0	0	0	1	0	0	0	9728	942	33	1	3137	1	MPHOSPH9	12	123706297	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	10191032	123706297	10145598	141	22304										
PABPC3	5042	broad.mit.edu	37	chr13	25670975	25670975	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cttaaggatctctttggcaaGttcgggcccgccttaagtgt	11	10	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr13:25670975G>T	uc001upy.2	+	1	700	c.639G>T	c.(637-639)AAG>AAT	p.K213N		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	213	RRM 3.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCTTTGGCAAGTTCGGGCCCG	0.428													1	0	1.23904e-05	0.014758	1.34354e-05	5	61										T	25670975	G	T	25670975	3	4	72	1	0	0	0	0	1	0	0	0	11365	1020	36	4	641	4	PABPC3	13	25670975	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		25670975	89498903	142	22305										
C13orf34	79866	broad.mit.edu	37	chr13	73317730	73317730	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aagctgaccattcattctgaGaaaagcgatggtgagtatga	11	6	2	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr13:73317730G>C	uc001viv.1	+	6	563	c.444G>C	c.(442-444)GAG>GAC	p.E148D	C13orf34_uc010thq.1_5'UTR|C13orf34_uc010aen.1_Missense_Mutation_p.E223D|C13orf34_uc010thr.1_Missense_Mutation_p.E78D|C13orf34_uc001viw.1_Missense_Mutation_p.E97D	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	148					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		TTCATTCTGAGAAAAGCGATG	0.343													0	0	0	0.014758	0	4	51										C	73317730	G	C	73317730	3	2	72	1	0	0	0	0	1	0	0	0	1728	933	33	1	462	1	C13orf34	13	73317730	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	47646755	73317730	41852148	143	22306										
TGM1	7051	broad.mit.edu	37	chr14	24727874	24727874	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggtggccagacccaggcagcGcagcactgtggaggagcgaa	17	11	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr14:24727874G>A	uc001wod.2	-	8	1289	c.1165C>T	c.(1165-1167)CGC>TGC	p.R389C	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	389			R -> H (in NCIE).|R -> P (in ARCI-TGM1).		cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CCCAGGCAGCGCAGCACTGTG	0.567													0	0	0	0.009096	0	4	38										A	24727874	G	A	24727874	3	1	72	1	0	0	0	0	1	0	0	0	15826	1087	38	2	1320	2	TGM1	14	24727874	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		24727874	82621666	144	22307										
STON2	85439	broad.mit.edu	37	chr14	81744238	81744238	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acagatctccagcttgaactCacggaatggtttttctaggc	9	10	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr14:81744238C>T	uc010tvu.1	-	4	1618	c.1417G>A	c.(1417-1419)GAG>AAG	p.E473K	STON2_uc001xvk.1_Missense_Mutation_p.E473K|STON2_uc010tvt.1_Missense_Mutation_p.E270K	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	473	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		AGCTTGAACTCACGGAATGGT	0.493													0	0	0	0.001984	0	7	169										T	81744238	C	T	81744238	3	4	72	1	0	0	0	0	1	0	0	0	15317	835	29	1	1306	1	STON2	14	81744238	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	57016364	81744238	25605302	145	22308										
PPP1R13B	23368	broad.mit.edu	37	chr14	104263749	104263749	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctaaatggcagctgccttctCcaggttccttgcaaaattct	7	12	2	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr14:104263749C>T	uc001yof.1	-	2	399	c.116G>A	c.(115-117)GGA>GAA	p.G39E	PPP1R13B_uc001yog.1_5'UTR	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	39					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GCTGCCTTCTCCAGGTTCCTT	0.378													0	0	0	0.008871	0	17	116										T	104263749	C	T	104263749	3	4	72	1	0	0	0	0	1	0	0	0	12357	855	30	1	3220	1	PPP1R13B	14	104263749	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	22519511	104263749	3085791	146	22309										
C14orf2	9556	broad.mit.edu	37	chr14	104381411	104381411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aaggaaacgtaccagcagccCggattttataaacgatgaag	10	8	0	1	rs149160111	byFrequency	TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr14:104381411C>T	uc001yoi.3	-	2	213	c.116G>A	c.(115-117)CGG>CAG	p.R39Q	C14orf2_uc001yoj.3_Missense_Mutation_p.R56Q|C14orf2_uc010aww.1_Missense_Mutation_p.R39Q|C14orf2_uc001yok.2_Missense_Mutation_p.R39Q	NM_004894	NP_004885	P56378	68MP_HUMAN	6.8 kDa mitochondrial proteolipid isoform 1	39						mitochondrion					0				Epithelial(152;0.223)		ACCAGCAGCCCGGATTTTATA	0.383													0	0	0	0.001168	0	4	58										T	104381411	C	T	104381411	3	4	72	1	0	0	0	0	1	0	0	0	1768	652	23	2	72	2	C14orf2	14	104381411	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	117662	104381411	2968129	147	22310										
MKRN3	7681	broad.mit.edu	37	chr15	23811314	23811314	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctggtcggaagatggccactGagggtggcgtttcgccgcct	16	11	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr15:23811314G>A	uc001ywh.3	+	1	861	c.385G>A	c.(385-387)GAG>AAG	p.E129K	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.E129K	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	129						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GATGGCCACTGAGGGTGGCGT	0.622													0	0	0	0.001984	0	5	42										A	23811314	G	A	23811314	3	1	72	1	0	0	0	0	1	0	0	0	9608	1291	45	1	387	1	MKRN3	15	23811314	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		23811314	78720078	148	22311										
MAP1A	4130	broad.mit.edu	37	chr15	43820200	43820200	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tctcctcattgcagccagctCccccacagctgccctctcca	5	21	3	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr15:43820200C>A	uc001zrt.2	+	4	6996	c.6529C>A	c.(6529-6531)CCC>ACC	p.P2177T		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2177						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCAGCCAGCTCCCCCACAGCT	0.652													1	0	3.83957e-06	0.016522	4.1971e-06	20	146										A	43820200	C	A	43820200	3	1	72	1	0	0	0	0	1	0	0	0	9227	855	30	3	6531	3	MAP1A	15	43820200	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	20008886	43820200	58711192	149	22312										
FRMD5	84978	broad.mit.edu	37	chr15	44181066	44181066	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aaatttcagcttggtcacctCattcctagaagcacaaagat	6	10	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr15:44181066C>G	uc001ztl.2	-	9	910	c.733G>C	c.(733-735)GAG>CAG	p.E245Q	FRMD5_uc001ztj.1_5'UTR|FRMD5_uc001ztk.1_Missense_Mutation_p.E156Q|FRMD5_uc001ztm.2_5'UTR|FRMD5_uc001ztn.2_Missense_Mutation_p.E11Q	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	245	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		TTGGTCACCTCATTCCTAGAA	0.478													0	0	0	0.001984	0	7	52										G	44181066	C	G	44181066	3	3	72	1	0	0	0	0	1	0	0	0	6053	835	29	1	1003	1	FRMD5	15	44181066	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	360866	44181066	58350326	150	22313										
SPPL2A	84888	broad.mit.edu	37	chr15	51041038	51041038	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gaaaggttgcatagtggtgtGgaagtcagattcatcaaact	12	5	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr15:51041038G>A	uc001zyv.2	-	3	387	c.207C>T	c.(205-207)TCC>TCT	p.S69S		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	69	Cytoplasmic (Potential).|PA.					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		ATAGTGGTGTGGAAGTCAGAT	0.353													0	0	0	0.013537	0	11	106										A	51041038	G	A	51041038	2	1	72	1	0	0	0	0	0	0	0	1	15087	1335	47	2		2	SPPL2A	15	51041038	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	6859972	51041038	51490354	151	22314										
MCTP2	55784	broad.mit.edu	37	chr15	95019959	95019959	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	actaagaagcttcgaaatccCtattccatcgacaataatga	5	10	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr15:95019959C>T	uc002btj.2	+	21	2570	c.2505C>T	c.(2503-2505)CCC>CCT	p.P835P	MCTP2_uc010boj.2_Silent_p.P564P|MCTP2_uc010bok.2_Silent_p.P780P|MCTP2_uc002btl.2_Silent_p.P423P	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	835					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TTCGAAATCCCTATTCCATCG	0.308													0	0	0	0.004482	0	8	59										T	95019959	C	T	95019959	2	4	72	1	0	0	0	0	0	0	0	1	9401	668	24	2		2	MCTP2	15	95019959	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	43978921	95019959	7511433	152	22315										
A2BP1	54715	broad.mit.edu	37	chr16	7645615	7645616	+	Frame_Shift_Ins	INS	-	-	CA													0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcgagggagaaattacacggINScaccgtggtagagggccgta							TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:7645615_7645616insCA	uc002cys.2	+	8	1521_1522	c.533_534insCA	c.(532-534)GGCfs	p.G178fs	A2BP1_uc010buf.1_Frame_Shift_Ins_p.G178fs|A2BP1_uc002cyr.1_Frame_Shift_Ins_p.G177fs|A2BP1_uc002cyt.2_Frame_Shift_Ins_p.G178fs|A2BP1_uc010uxz.1_Frame_Shift_Ins_p.G221fs|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Frame_Shift_Ins_p.G178fs|A2BP1_uc010uyb.1_Frame_Shift_Ins_p.G178fs|A2BP1_uc002cyw.2_Frame_Shift_Ins_p.G198fs|A2BP1_uc002cyy.2_Frame_Shift_Ins_p.G198fs|A2BP1_uc002cyx.2_Frame_Shift_Ins_p.G198fs|A2BP1_uc010uyc.1_Frame_Shift_Ins_p.G198fs	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	178	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AAATTACACGGCACCGTGGTAG	0.45																		8	133	---	---								CA	7645616	-	CA	7645615	7	5	72	1	0	1	1	0	0	0	0	0	3	1203	42	0	642	0	A2BP1	16	7645615	Frame_Shift_Ins	INS	-	TCGA-FD-A3B3-01A-12D-A202-08		7645615	82709138	153	22316										
TXNDC11	51061	broad.mit.edu	37	chr16	11773514	11773514	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctctcagtttctggatctctCtctccaagtgggagatgtgc	10	11	4	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:11773514C>G	uc010buu.1	-	13	2557	c.2495G>C	c.(2494-2496)AGA>ACA	p.R832T	TXNDC11_uc002dbg.1_Missense_Mutation_p.R805T	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	832	Potential.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						CTGGATCTCTCTCTCCAAGTG	0.582													0	0	0	0.001168	0	5	39										G	11773514	C	G	11773514	3	3	72	1	0	0	0	0	1	0	0	0	16789	913	32	1	466	1	TXNDC11	16	11773514	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	4127899	11773514	78581239	154	22317										
TMC5	79838	broad.mit.edu	37	chr16	19501754	19501754	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	actgtggcccttttcgaggtCtgcctctcttcattcactcc	7	15	4	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:19501754C>G	uc002dgc.3	+	18	3360	c.2611C>G	c.(2611-2613)CTG>GTG	p.L871V	TMC5_uc010vaq.1_Missense_Mutation_p.L819V|TMC5_uc002dgb.3_Intron|TMC5_uc010var.1_Missense_Mutation_p.L871V|TMC5_uc002dgd.1_Missense_Mutation_p.L625V|TMC5_uc002dge.3_Missense_Mutation_p.L625V|TMC5_uc002dgf.3_Missense_Mutation_p.L554V|TMC5_uc002dgg.3_Missense_Mutation_p.L512V	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	871	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						TTTTCGAGGTCTGCCTCTCTT	0.478													0	0	0	0.007413	0	19	116										G	19501754	C	G	19501754	3	3	72	1	0	0	0	0	1	0	0	0	15985	912	32	1	2987	1	TMC5	16	19501754	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	7728240	19501754	70852999	155	22318										
PAPD5	64282	broad.mit.edu	37	chr16	50257151	50257151	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttctcttaatagaattttttGaattatatggacgacacttc	5	6	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:50257151G>A	uc010vgo.1	+	8	1224	c.1189G>A	c.(1189-1191)GAA>AAA	p.E397K	PAPD5_uc010cbi.2_RNA|PAPD5_uc002efz.2_Missense_Mutation_p.E188K|PAPD5_uc002ega.2_Missense_Mutation_p.E188K	NM_001040284	NP_001035374	Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5 isoform a	318	PAP-associated.				cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding				0		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)		AGAATTTTTTGAATTATATGG	0.343													0	0	0	0.009096	0	4	59										A	50257151	G	A	50257151	3	1	72	1	0	0	0	0	1	0	0	0	11425	1291	45	1	1219	1	PAPD5	16	50257151	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	30755397	50257151	40097602	156	22319										
CX3CL1	6376	broad.mit.edu	37	chr16	57406489	57406489	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccaccctcagccatggctccGatatctctgtcgtggctgct	9	16	2	0	rs150111366		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:57406489G>A	uc002eli.2	+	1	76	c.9G>A	c.(7-9)CCG>CCA	p.P3P		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	3					cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						CCATGGCTCCGATATCTCTGT	0.657													0	0	0	0.020292	0	12	42										A	57406489	G	A	57406489	2	1	72	1	0	0	0	0	0	0	0	1	4074	1045	37	1		1	CX3CL1	16	57406489	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	7149338	57406489	32948264	157	22320										
CDH11	1009	broad.mit.edu	37	chr16	64984875	64984875	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agaaggtacaagtcctgcttCtgccgactgaaccctccacg	9	14	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:64984875C>T	uc002eoi.2	-	12	2123	c.1689G>A	c.(1687-1689)CAG>CAA	p.Q563Q	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.Q563Q|CDH11_uc010vin.1_Silent_p.Q437Q	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	563	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGTCCTGCTTCTGCCGACTGA	0.592			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.013537	0	11	32										T	64984875	C	T	64984875	2	4	72	1	0	0	0	0	0	0	0	1	3097	912	32	1		1	CDH11	16	64984875	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	7578386	64984875	25369878	158	22321										
CTCF	10664	broad.mit.edu	37	chr16	67662347	67662347	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgcagccactgcgataagacCttccgccagaagcagcttct	9	14	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:67662347C>A	uc002etl.2	+	9	1883	c.1593C>A	c.(1591-1593)ACC>ACA	p.T531T	CTCF_uc010cek.2_Silent_p.T203T|CTCF_uc002etm.1_Silent_p.T20T	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	531	C2H2-type 10.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		GCGATAAGACCTTCCGCCAGA	0.547													1	0	1.10513e-12	0.014323	1.25372e-12	23	76										A	67662347	C	A	67662347	2	1	72	1	0	0	0	0	0	0	0	1	4000	668	24	4		4	CTCF	16	67662347	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	2677472	67662347	22692406	159	22322										
NUDT7	283927	broad.mit.edu	37	chr16	77759451	77759451	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtggctaaagaaggaaaactCcatttgttgttcaccgtccg	10	9	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr16:77759451C>G	uc010chd.2	+	2	228	c.159C>G	c.(157-159)CTC>CTG	p.L53L	NUDT7_uc002fff.2_Silent_p.L53L|NUDT7_uc010vnj.1_Silent_p.L53L	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	53	Nudix hydrolase.				nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						AAGGAAAACTCCATTTGTTGT	0.428													0	0	0	0.003163	0	12	41										G	77759451	C	G	77759451	2	3	72	1	0	0	0	0	0	0	0	1	10744	842	30	1		1	NUDT7	16	77759451	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	10097104	77759451	12595302	160	22323										
PRPF8	10594	broad.mit.edu	37	chr17	1562039	1562039	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atgagaggcttgctgcctggGaaccagtttccataggcact	12	10	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:1562039G>A	uc002fte.2	-	33	5271	c.5157C>T	c.(5155-5157)TTC>TTT	p.F1719F		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1719	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGCTGCCTGGGAACCAGTTTC	0.507													0	0	0	0.001984	0	6	60										A	1562039	G	A	1562039	2	1	72	1	0	0	0	0	0	0	0	1	12575	1165	41	1		1	PRPF8	17	1562039	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		1562039	79633171	161	22324										
DNAH2	146754	broad.mit.edu	37	chr17	7721269	7721269	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ccccttgctctctagggcctGaagatcatcgacctgcagat	9	14	2	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:7721269G>C	uc002giu.1	+	67	10256	c.10242G>C	c.(10240-10242)CTG>CTC	p.L3414L	DNAH2_uc010cnm.1_Silent_p.L352L	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3414	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TCTAGGGCCTGAAGATCATCG	0.577													0	0	0	0.003163	0	13	103										C	7721269	G	C	7721269	2	2	72	1	0	0	0	0	0	0	0	1	4602	1277	45	1		1	DNAH2	17	7721269	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	6159230	7721269	73473941	162	22325										
GUCY2D	3000	broad.mit.edu	37	chr17	7915609	7915609	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctcttcaggacctcctcgctCagagagaaataaagctggac	9	12	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:7915609C>T	uc002gjt.2	+	9	1971	c.1897C>T	c.(1897-1899)CAG>TAG	p.Q633*		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	633	Protein kinase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				CCTCCTCGCTCAGAGAGAAAT	0.632													0	0	0	0.009096	0	4	56										T	7915609	C	T	7915609	4	4	72	1	0	0	0	0	0	1	0	0	6897	827	29	1	1927	1	GUCY2D	17	7915609	Nonsense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	194340	7915609	73279601	163	22326										
KRT28	162605	broad.mit.edu	37	chr17	38955182	38955182	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cacttactttagcctgaaatCatcagcagccagtctggcat	7	12	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:38955182C>A	uc002hvh.1	-	2	586	c.520G>T	c.(520-522)GAT>TAT	p.D174Y		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	174	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				AGCCTGAAATCATCAGCAGCC	0.318													1	0	1.26484e-09	0.00308	1.41119e-09	6	122										A	38955182	C	A	38955182	3	1	72	1	0	0	0	0	1	0	0	0	8465	826	29	3	902	3	KRT28	17	38955182	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	31039573	38955182	42240028	164	22327										
BRIP1	83990	broad.mit.edu	37	chr17	59926522	59926522	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttctaagggtcgaattctttTcttctctacttgaaaatcat	5	8	5	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:59926522T>C	uc002izk.1	-	5	616	c.475A>G	c.(475-477)AAA>GAA	p.K159E		NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	159	Nuclear localization signal (Potential).|Helicase ATP-binding.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						CGAATTCTTTTCTTCTCTACT	0.378			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.020292	0	15	92										C	59926522	T	C	59926522	3	2	72	1	0	0	0	0	1	0	0	0	1514	1792	62	5	3338	5	BRIP1	17	59926522	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	20971340	59926522	21268688	165	22328										
SCN4A	6329	broad.mit.edu	37	chr17	62038715	62038715	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttgaacttcagccacggggcGcagcagttccatatgagcac	11	12	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:62038715G>A	uc002jds.1	-	11	1760	c.1683C>T	c.(1681-1683)TGC>TGT	p.C561C		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	561					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GCCACGGGGCGCAGCAGTTCC	0.562													0	0	0	0.008291	0	9	197										A	62038715	G	A	62038715	2	1	72	1	0	0	0	0	0	0	0	1	13920	1079	38	2		2	SCN4A	17	62038715	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	2112193	62038715	19156495	166	22329										
CSNK1D	1453	broad.mit.edu	37	chr17	80223620	80223620	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tggagctgagggtgtttggtTttgacacattcaagcttgat	13	5	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr17:80223620T>C	uc002kej.2	-	2	445	c.129A>G	c.(127-129)AAA>AAG	p.K43K	CSNK1D_uc002kef.2_Silent_p.K43K|CSNK1D_uc002kei.2_Silent_p.K43K|CSNK1D_uc010wvj.1_5'UTR	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	43	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			GGTGTTTGGTTTTGACACATT	0.463													0	0	0	0.00308	0	7	127										C	80223620	T	C	80223620	2	2	72	1	0	0	0	0	0	0	0	1	3952	1838	64	5		5	CSNK1D	17	80223620	Silent	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	18184905	80223620	971590	167	22330										
EMILIN2	84034	broad.mit.edu	37	chr18	2913063	2913063	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gggtttgcctttctccccgcAggggtcttcacggctcctta	11	14	3	0	rs113730111		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr18:2913063A>C	uc002kln.2	+	8	2984	c.2825_splice	c.e8-2	p.G942_splice		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor						cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TTCTCCCCGCAGGGGTCTTCA	0.617													0	0	0	0.009096	0	4	39										C	2913063	A	C	2913063	5	2	72	1	0	0	0	0	0	0	1	0	5094	202	7	5	2853	5	EMILIN2	18	2913063	Splice_Site	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08		2913063	75164185	168	22331										
C18orf8	29919	broad.mit.edu	37	chr18	21083604	21083604	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgggcgaggaggactactatCtggagctgtgcgagcggccg	18	9	1	0	rs143953070	byFrequency	TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr18:21083604C>T	uc010xax.1	+	1	143	c.22C>T	c.(22-24)CTG>TTG	p.L8L	C18orf8_uc010xau.1_5'UTR|C18orf8_uc010xav.1_Silent_p.L8L|C18orf8_uc010xaw.1_5'UTR|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	8										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GGACTACTATCTGGAGCTGTG	0.537													0	0	0	0.009096	0	4	38										T	21083604	C	T	21083604	2	4	72	1	0	0	0	0	0	0	0	1	1907	912	32	1		1	C18orf8	18	21083604	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	18170541	21083604	56993644	169	22332										
ATP5A1	498	broad.mit.edu	37	chr18	43668178	43668178	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttttcatcagatccatcattGaaacgtttctggttaatgat	6	7	4	3	rs59386231		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr18:43668178G>A	uc002lbr.1	-	6	786	c.696C>T	c.(694-696)TTC>TTT	p.F232F	ATP5A1_uc010dnl.1_Silent_p.F182F|ATP5A1_uc002lbs.1_Silent_p.F182F|ATP5A1_uc002lbt.1_Silent_p.F232F	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	232					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						ATCCATCATTGAAACGTTTCT	0.343													0	0	0	0.004482	0	7	85										A	43668178	G	A	43668178	2	1	72	1	0	0	0	0	0	0	0	1	1147	1281	45	1		1	ATP5A1	18	43668178	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	22584574	43668178	34409070	170	22333										
KATNAL2	83473	broad.mit.edu	37	chr18	44593394	44593394	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atcaaatgtgcattgcaggaCatttatctccataatccaaa	5	9	2	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr18:44593394C>T	uc002lco.2	+	8	707	c.513C>T	c.(511-513)GAC>GAT	p.D171D	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Intron	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	243						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						CATTGCAGGACATTTATCTCC	0.353													0	0	0	0.009096	0	4	34										T	44593394	C	T	44593394	2	4	72	1	0	0	0	0	0	0	0	1	7986	477	17	2		2	KATNAL2	18	44593394	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	925216	44593394	33483854	171	22334										
MC4R	4160	broad.mit.edu	37	chr18	58038747	58038748	+	Frame_Shift_Del	DEL	CA	CA	-													0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agttaaagtgagacatgaagCacacacaatatggattctga							TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr18:58038747_58038748delCA	uc002lie.1	-	1	1254_1255	c.835_836delTG	c.(835-837)TGCfs	p.C279fs		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	279	Extracellular (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				AGACATGAAGCACACACAATAT	0.421																		11	59	---	---								-	58038748	CA	-	58038747	7	5	72	1	0	1	0	1	0	0	0	0	9366	710	25	0	166	0	MC4R	18	58038747	Frame_Shift_Del	DEL	CA	TCGA-FD-A3B3-01A-12D-A202-08	13445353	58038747	20038501	172	22335										
CDH20	28316	broad.mit.edu	37	chr18	59206358	59206358	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tctatgaagcttttgtctgtGagaacgccaaggcaggacag	12	8	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr18:59206358G>C	uc010dps.1	+	8	1522	c.1510G>C	c.(1510-1512)GAG>CAG	p.E504Q	CDH20_uc002lif.2_Missense_Mutation_p.E498Q	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	504	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TTTTGTCTGTGAGAACGCCAA	0.463													0	0	0	0.014323	0	20	121										C	59206358	G	C	59206358	3	2	72	1	0	0	0	0	1	0	0	0	3106	1291	45	1	1540	1	CDH20	18	59206358	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1167611	59206358	18870890	173	22336										
PRTN3	5657	broad.mit.edu	37	chr19	843531	843531	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcccggccctacatggcctcCctgcagatgcgggggaaccc	12	17	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:843531C>T	uc002lqa.1	+	2	156	c.132C>T	c.(130-132)TCC>TCT	p.S44S		NM_002777	NP_002768	P24158	PRTN3_HUMAN	myeloblastin	44	Peptidase S1.				collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACATGGCCTCCCTGCAGATGC	0.706													0	0	0	0.009096	0	3	4										T	843531	C	T	843531	2	4	72	1	0	0	0	0	0	0	0	1	12639	610	22	2		2	PRTN3	19	843531	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08		843531	58285452	174	22337										
DPP9	91039	broad.mit.edu	37	chr19	4704192	4704192	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agtggaagaggctgttgctgGcctggaagaggaagaggcca	18	6	0	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:4704192G>C	uc002mba.2	-	6	809	c.551C>G	c.(550-552)GCC>GGC	p.A184G	DPP9_uc002mbb.2_Missense_Mutation_p.A184G|DPP9_uc002mbc.2_Missense_Mutation_p.A184G	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	155					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GCTGTTGCTGGCCTGGAAGAG	0.672													0	0	0	0.004672	0	3	56										C	4704192	G	C	4704192	3	2	72	1	0	0	0	0	1	0	0	0	4733	1203	42	4	2195	4	DPP9	19	4704192	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3860661	4704192	54424791	175	22338										
EVI5L	115704	broad.mit.edu	37	chr19	7917998	7917998	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cagagagtgatcccccaccaGttcgacagctgcccggacaa	10	15	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:7917998G>C	uc002min.2	+	9	1168	c.1014G>C	c.(1012-1014)CAG>CAC	p.Q338H	EVI5L_uc010xjz.1_Missense_Mutation_p.Q338H|EVI5L_uc002mio.1_Missense_Mutation_p.Q69H	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	338						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						TCCCCCACCAGTTCGACAGCT	0.617											OREG0025211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	7	161										C	7917998	G	C	7917998	3	2	72	1	0	0	0	0	1	0	0	0	5290	1020	36	4	1044	4	EVI5L	19	7917998	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3213806	7917998	51210985	176	22339										
SLC7A9	11136	broad.mit.edu	37	chr19	33355033	33355033	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcggccaggcatttcacaacGatttgaggaggcttgcagcc	13	11	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:33355033G>A	uc002ntv.3	-	4	564	c.447C>T	c.(445-447)ATC>ATT	p.I149I	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Silent_p.I149I|SLC7A9_uc002ntw.3_5'UTR	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	149	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	ATTTCACAACGATTTGAGGAG	0.597													0	0	0	0.00308	0	4	52										A	33355033	G	A	33355033	2	1	72	1	0	0	0	0	0	0	0	1	14705	1048	37	1		1	SLC7A9	19	33355033	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	25437035	33355033	25773950	177	22340										
USF2	7392	broad.mit.edu	37	chr19	35769607	35769607	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tctgttttccgcagtggagcGgaggcggagggacaagatca	16	8	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:35769607G>A	uc002nyq.1	+	8	843	c.734G>A	c.(733-735)CGG>CAG	p.R245Q	USF2_uc010xss.1_Missense_Mutation_p.R245Q|USF2_uc002nyr.1_Missense_Mutation_p.R178Q|USF2_uc002nys.1_Missense_Mutation_p.R47Q|USF2_uc002nyt.1_Missense_Mutation_p.R114Q|USF2_uc002nyu.1_Missense_Mutation_p.R47Q|USF2_uc002nyv.1_Missense_Mutation_p.R47Q	NM_003367	NP_003358	Q15853	USF2_HUMAN	upstream stimulatory factor 2 isoform 1	245	Poly-Arg.|Basic motif.				lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by glucose	nucleus	bHLH transcription factor binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity				0	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GCAGTGGAGCGGAGGCGGAGG	0.597													0	0	0	0.012213	0	29	162										A	35769607	G	A	35769607	3	1	72	1	0	0	0	0	1	0	0	0	17030	1116	39	2	764	2	USF2	19	35769607	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	2414574	35769607	23359376	178	22341										
LGALS7B	653499	broad.mit.edu	37	chr19	39281455	39281455	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggctcctggggccgcgaggaGcgcgggccgggcgttccttt	19	13	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:39281455G>A	uc002ojf.3	+	3	239	c.222G>A	c.(220-222)GAG>GAA	p.E74E		NM_001042507	NP_001035972	P47929	LEG7_HUMAN	galectin-7B	74	Galectin.|Beta-galactoside binding (Potential).				apoptosis|heterophilic cell-cell adhesion	cytoplasm|extracellular space|nucleus	sugar binding				0						GCCGCGAGGAGCGCGGGCCGG	0.677													0	0	0	0.014758	0	3	19										A	39281455	G	A	39281455	2	1	72	1	0	0	0	0	0	0	0	1	8746	962	34	2		2	LGALS7B	19	39281455	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	3511848	39281455	19847528	179	22342										
CEACAM5	1048	broad.mit.edu	37	chr19	42224859	42224859	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cagatgggccggacacccccAtcatttcccccccagactcg	8	19	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:42224859A>T	uc002ork.2	+	8	1910	c.1789A>T	c.(1789-1791)ATC>TTC	p.I597F	CEACAM5_uc002orj.1_Missense_Mutation_p.I596F|CEACAM5_uc002orl.2_Missense_Mutation_p.I597F	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	597	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GGACACCCCCATCATTTCCCC	0.552													0	0	0	0.008361	0	27	157										T	42224859	A	T	42224859	3	4	72	1	0	0	0	0	1	0	0	0	3195	217	8	5	1819	5	CEACAM5	19	42224859	Missense_Mutation	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	2943404	42224859	16904124	180	22343										
PSG1	5669	broad.mit.edu	37	chr19	43372318	43372318	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctgagttacgaacagagcaaAcatagagcccgctatgcttt	9	10	0	3	rs1058795		TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:43372318A>G	uc002ovb.2	-	5	1316	c.1178T>C	c.(1177-1179)GTT>GCT	p.V393A	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Missense_Mutation_p.V393A|PSG1_uc010eio.1_Missense_Mutation_p.V393A|PSG1_uc002oux.1_Missense_Mutation_p.V322A|PSG1_uc002ouy.1_Missense_Mutation_p.V300A|PSG1_uc002ouz.1_Missense_Mutation_p.V393A|PSG1_uc002ova.1_Missense_Mutation_p.V300A|PSG1_uc002ovc.2_Missense_Mutation_p.V300A|PSG1_uc002ovd.1_Missense_Mutation_p.V393A	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	393	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				AACAGAGCAAACATAGAGCCC	0.458													0	0	0	0.009535	0	28	258										G	43372318	A	G	43372318	3	3	72	1	0	0	0	0	1	0	0	0	12653	43	2	5	142	5	PSG1	19	43372318	Missense_Mutation	SNP	A	TCGA-FD-A3B3-01A-12D-A202-08	1147459	43372318	15756665	181	22344										
PSG1	5669	broad.mit.edu	37	chr19	43372335	43372335	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	caaacatagagcccgctatgCtttgtagtaatatggcggat	10	8	0	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:43372335C>A	uc002ovb.2	-	5	1299	c.1161G>T	c.(1159-1161)AAG>AAT	p.K387N	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Missense_Mutation_p.K387N|PSG1_uc010eio.1_Missense_Mutation_p.K387N|PSG1_uc002oux.1_Missense_Mutation_p.K316N|PSG1_uc002ouy.1_Missense_Mutation_p.K294N|PSG1_uc002ouz.1_Missense_Mutation_p.K387N|PSG1_uc002ova.1_Missense_Mutation_p.K294N|PSG1_uc002ovc.2_Missense_Mutation_p.K294N|PSG1_uc002ovd.1_Missense_Mutation_p.K387N	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	387	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GCCCGCTATGCTTTGTAGTAA	0.463													1	0	5.8336e-16	0.015359	6.64588e-16	31	254										A	43372335	C	A	43372335	3	1	72	1	0	0	0	0	1	0	0	0	12653	796	28	4	159	4	PSG1	19	43372335	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	17	43372335	15756648	182	22345										
SLC17A7	57030	broad.mit.edu	37	chr19	49934671	49934671	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cccttggagtgcgagtagccGaccaccaacagcagcgtggc	13	14	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:49934671G>C	uc002pnp.2	-	10	1357	c.1185C>G	c.(1183-1185)GTC>GTG	p.V395V	SLC17A7_uc002pno.2_Intron	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	395	Helical; (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GCGAGTAGCCGACCACCAACA	0.577													0	0	0	0.006214	0	10	45										C	49934671	G	C	49934671	2	2	72	1	0	0	0	0	0	0	0	1	14422	1045	37	1		1	SLC17A7	19	49934671	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	6562336	49934671	9194312	183	22346										
ALDH16A1	126133	broad.mit.edu	37	chr19	49965942	49965942	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggatggggccgtggacatggGggcccggggggctgccgcat	22	10	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:49965942G>T	uc002pnt.2	+	8	1144	c.1028G>T	c.(1027-1029)GGG>GTG	p.G343V	ALDH16A1_uc010yar.1_Missense_Mutation_p.G292V|ALDH16A1_uc010yas.1_Missense_Mutation_p.G178V|ALDH16A1_uc010yat.1_Missense_Mutation_p.G180V	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	343							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GTGGACATGGGGGCCCGGGGG	0.672													1	0	3.86212e-05	0.008291	4.15447e-05	9	40										T	49965942	G	T	49965942	3	4	72	1	0	0	0	0	1	0	0	0	488	1232	43	4	1058	4	ALDH16A1	19	49965942	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	31271	49965942	9163041	184	22347										
AP2A1	160	broad.mit.edu	37	chr19	50303343	50303343	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gagtgaggaggtgtggtaccGtgtgctacagatcgtcacca	15	8	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:50303343G>A	uc002ppn.2	+	11	1602	c.1391G>A	c.(1390-1392)CGT>CAT	p.R464H	AP2A1_uc010enj.1_Intron|AP2A1_uc002ppo.2_Missense_Mutation_p.R464H|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	464					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		GTGTGGTACCGTGTGCTACAG	0.592													0	0	0	0.014758	0	5	17										A	50303343	G	A	50303343	3	1	72	1	0	0	0	0	1	0	0	0	739	1145	40	2	1433	2	AP2A1	19	50303343	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	337401	50303343	8825640	185	22348										
ZNF473	25888	broad.mit.edu	37	chr19	50549435	50549435	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gctgcagcaaatacctaactCagcacgagaggattcacacc	8	13	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:50549435C>G	uc002prn.2	+	5	1972	c.1735C>G	c.(1735-1737)CAG>GAG	p.Q579E	ZNF473_uc002prm.2_Missense_Mutation_p.Q579E|ZNF473_uc010ybo.1_Missense_Mutation_p.Q567E	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	579	C2H2-type 11.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		ATACCTAACTCAGCACGAGAG	0.453													0	0	0	0.001984	0	7	44										G	50549435	C	G	50549435	3	3	72	1	0	0	0	0	1	0	0	0	17928	827	29	1	1749	1	ZNF473	19	50549435	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	246092	50549435	8579548	186	22349										
ZNF577	84765	broad.mit.edu	37	chr19	52376173	52376173	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	caaaggctttgccacattctCtgcatgaatatggtctctct	7	11	3	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:52376173C>G	uc010yde.1	-	7	1461	c.1070G>C	c.(1069-1071)AGA>ACA	p.R357T	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Missense_Mutation_p.R298T|ZNF577_uc002pxv.2_Missense_Mutation_p.R350T|ZNF577_uc002pxw.2_Missense_Mutation_p.R291T	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	357	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCCACATTCTCTGCATGAATA	0.428													0	0	0	0.009096	0	4	83										G	52376173	C	G	52376173	3	3	72	1	0	0	0	0	1	0	0	0	18006	913	32	1	391	1	ZNF577	19	52376173	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1826738	52376173	6752810	187	22350										
ZNF836	162962	broad.mit.edu	37	chr19	52658463	52658463	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtccccagtatgcattttctGatgattaaccagaattgaac	7	9	1	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:52658463G>A	uc010ydi.1	-	5	2847	c.2473C>T	c.(2473-2475)CAG>TAG	p.Q825*	ZNF836_uc010ydj.1_Nonsense_Mutation_p.Q825*	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	825	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCATTTTCTGATGATTAACC	0.398													0	0	0	0.00632	0	26	132										A	52658463	G	A	52658463	4	1	72	1	0	0	0	0	0	1	0	0	18184	1299	45	1	339	1	ZNF836	19	52658463	Nonsense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	282290	52658463	6470520	188	22351										
ZNF761	388561	broad.mit.edu	37	chr19	53958025	53958025	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aatggagatttttgctaccaGgatgttgataaagatattca	9	4	1	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:53958025G>A	uc010eqp.2	+	7	722	c.264G>A	c.(262-264)CAG>CAA	p.Q88Q	ZNF761_uc010ydy.1_Silent_p.Q34Q|ZNF761_uc002qbt.1_Silent_p.Q34Q	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TTTGCTACCAGGATGTTGATA	0.388													0	0	0	0.016723	0	14	53										A	53958025	G	A	53958025	2	1	72	1	0	0	0	0	0	0	0	1	18133	991	35	2		2	ZNF761	19	53958025	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	1299562	53958025	5170958	189	22352										
ISOC2	79763	broad.mit.edu	37	chr19	55967807	55967807	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgtcacacaggaacaggacaGaggatcctgggaggactcgg	15	9	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr19:55967807G>C	uc002qlb.2	-	2	221	c.47C>G	c.(46-48)TCT>TGT	p.S16C	ISOC2_uc002qla.2_Missense_Mutation_p.S16C|ISOC2_uc002qlc.2_Missense_Mutation_p.S16C	NM_001136201	NP_001129673	Q96AB3	ISOC2_HUMAN	isochorismatase domain containing 2 isoform 1	16					protein destabilization	mitochondrion|nucleus	catalytic activity|protein binding			ovary(1)	1	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0535)		GAACAGGACAGAGGATCCTGG	0.617													0	0	0	0.008291	0	10	80										C	55967807	G	C	55967807	3	2	72	1	0	0	0	0	1	0	0	0	7863	942	33	1	638	1	ISOC2	19	55967807	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	2009782	55967807	3161176	190	22353										
C20orf26	26074	broad.mit.edu	37	chr20	20144789	20144789	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctcgtactgcctgaagagccCgtccacttccgccccatcta	7	18	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr20:20144789C>A	uc002wru.2	+	11	1198	c.1122C>A	c.(1120-1122)CCC>CCA	p.P374P	C20orf26_uc010gcw.1_Silent_p.P328P|C20orf26_uc010zse.1_Silent_p.P374P|C20orf26_uc010zsf.1_Silent_p.P374P	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	374										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CTGAAGAGCCCGTCCACTTCC	0.478													1	0	7.48243e-07	0.006214	8.24594e-07	9	88										A	20144789	C	A	20144789	2	1	72	1	0	0	0	0	0	0	0	1	2106	639	23	4		4	C20orf26	20	20144789	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08		20144789	42880731	191	22354										
XRN2	22803	broad.mit.edu	37	chr20	21312985	21312985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	accattattagagaagaattCaaaccaaacaagcccaaacc	4	11	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr20:21312985C>G	uc002wsf.1	+	9	860	c.765C>G	c.(763-765)TTC>TTG	p.F255L	XRN2_uc002wsg.1_Missense_Mutation_p.F179L|XRN2_uc010zsk.1_Missense_Mutation_p.F201L	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	255					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						GAGAAGAATTCAAACCAAACA	0.388													0	0	0	0.001168	0	6	48										G	21312985	C	G	21312985	3	3	72	1	0	0	0	0	1	0	0	0	17457	825	29	1	799	1	XRN2	20	21312985	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1168196	21312985	41712535	192	22355										
NKAIN4	128414	broad.mit.edu	37	chr20	61873940	61873941	+	Frame_Shift_Del	DEL	AG	AG	-													0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tggcttttcattgacatggtAgagaggaaatggatcaaatc							TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr20:61873940_61873941delAG	uc002yek.2	-	6	657_658	c.567_568delCT	c.(565-570)CTCTACfs	p.L189fs		NM_152864	NP_690603	Q8IVV8	NKAI4_HUMAN	Na+/K+ transporting ATPase interacting 4	189_190						integral to membrane|plasma membrane					0	all_cancers(38;2.72e-09)					TTGACATGGTAGAGAGGAAATG	0.446																		36	247	---	---								-	61873941	AG	-	61873940	7	5	72	1	0	1	0	1	0	0	0	0	10438	420	15	0	66	0	NKAIN4	20	61873940	Frame_Shift_Del	DEL	AG	TCGA-FD-A3B3-01A-12D-A202-08	40560955	61873940	1151580	193	22356										
RUNX1	861	broad.mit.edu	37	chr21	36421143	36421143	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	accagcatgtactcacctctCatgaagcactgtgggtacga	9	12	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr21:36421143C>G	uc010gmu.2	-	2	198	c.54G>C	c.(52-54)ATG>ATC	p.M18I	RUNX1_uc002yut.1_RNA|RUNX1_uc010gmv.2_Missense_Mutation_p.M18I|RUNX1_uc002yuj.3_5'UTR|RUNX1_uc002yuk.3_Missense_Mutation_p.M18I|RUNX1_uc002yum.1_5'UTR|RUNX1_uc010gmw.1_Missense_Mutation_p.M18I	NM_001754	NP_001745	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	Error:Variant_position_missing_in_Q01196_after_alignment					myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						ACTCACCTCTCATGAAGCACT	0.483			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				0	0	0	0.001984	0	6	172										G	36421143	C	G	36421143	3	3	72	1	0	0	0	0	1	0	0	0	13746	826	29	1	1469	1	RUNX1	21	36421143	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08		36421143	11708752	194	22357										
WDR4	10785	broad.mit.edu	37	chr21	44272389	44272389	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	cagcatggcccagttcccacGaagaacaccagagactttct	8	14	1	2	rs147294240	byFrequency	TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr21:44272389G>A	uc002zci.2	-	10	1094	c.1021C>T	c.(1021-1023)CGT>TGT	p.R341C	WDR4_uc002zck.1_Missense_Mutation_p.R341C|WDR4_uc002zcl.1_Missense_Mutation_p.R195C|WDR4_uc010gpg.1_Missense_Mutation_p.R340C|WDR4_uc011aew.1_Missense_Mutation_p.R195C|WDR4_uc010gph.1_Missense_Mutation_p.R195C	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	341					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CAGTTCCCACGAAGAACACCA	0.567													0	0	0	0.014758	0	4	24										A	44272389	G	A	44272389	3	1	72	1	0	0	0	0	1	0	0	0	17290	1058	37	1	225	1	WDR4	21	44272389	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	7851246	44272389	3857506	195	22358										
WDR4	10785	broad.mit.edu	37	chr21	44274683	44274683	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gcagcttacccgtcgcacagGagcgccacgcagttctcctg	11	16	1	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr21:44274683G>C	uc002zci.2	-	8	853	c.780C>G	c.(778-780)CTC>CTG	p.L260L	WDR4_uc002zck.1_Silent_p.L260L|WDR4_uc002zcl.1_Silent_p.L114L|WDR4_uc010gpg.1_Silent_p.L259L|WDR4_uc011aew.1_Silent_p.L114L|WDR4_uc010gph.1_Silent_p.L114L	NM_033661	NP_387510	P57081	WDR4_HUMAN	WD repeat domain 4 protein	260					tRNA modification	cytoplasm|nucleoplasm	protein binding			ovary(1)	1				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		CGTCGCACAGGAGCGCCACGC	0.612													0	0	0	0.009096	0	3	25										C	44274683	G	C	44274683	2	2	72	1	0	0	0	0	0	0	0	1	17290	1161	41	1		1	WDR4	21	44274683	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	2294	44274683	3855212	196	22359										
MCM3AP	8888	broad.mit.edu	37	chr21	47678906	47678906	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tggagggtctcctttgcagtCtggaagatttcctccacgag	12	10	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr21:47678906C>G	uc002zir.1	-	16	3717	c.3681G>C	c.(3679-3681)CAG>CAC	p.Q1227H	MCM3AP_uc002zip.1_5'UTR|MCM3AP_uc002ziq.1_Missense_Mutation_p.Q154H	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1227					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CCTTTGCAGTCTGGAAGATTT	0.537													0	0	0	0.001168	0	5	81										G	47678906	C	G	47678906	3	3	72	1	0	0	0	0	1	0	0	0	9388	912	32	1	2313	1	MCM3AP	21	47678906	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	3404223	47678906	450989	197	22360										
RIMBP3	85376	broad.mit.edu	37	chr22	20458068	20458068	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggtcctgccaagagtgtgtcGaaggtgacggtggaggacat	17	7	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr22:20458068G>A	uc002zsd.3	-	1	3719	c.3234C>T	c.(3232-3234)TTC>TTT	p.F1078F		NM_015672	NP_056487			RIMS binding protein 3												0	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AGAGTGTGTCGAAGGTGACGG	0.662													0	0	0	0.009096	0	4	35										A	20458068	G	A	20458068	2	1	72	1	0	0	0	0	0	0	0	1	13364	1049	37	1		1	RIMBP3	22	20458068	Silent	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		20458068	30846498	198	22361										
THAP7	80764	broad.mit.edu	37	chr22	21354354	21354354	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctgggccttgtcaagggcatCaagggctgcctcggctcgcc	14	14	2	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr22:21354354C>G	uc002ztr.1	-	5	775	c.745G>C	c.(745-747)GAT>CAT	p.D249H	THAP7_uc002zts.1_Missense_Mutation_p.D249H|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	249					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TCAAGGGCATCAAGGGCTGCC	0.682													0	0	0	0.006214	0	10	33										G	21354354	C	G	21354354	3	3	72	1	0	0	0	0	1	0	0	0	15846	826	29	1	188	1	THAP7	22	21354354	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	896286	21354354	29950212	199	22362										
LARGE	9215	broad.mit.edu	37	chr22	34046621	34046621	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	acctggggctgtgtgcctggGactccagcggtgacagagac	16	11	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr22:34046621G>A	uc003and.3	-	4	719	c.140C>T	c.(139-141)TCC>TTC	p.S47F	LARGE_uc003ane.3_Missense_Mutation_p.S47F|LARGE_uc010gwp.2_Missense_Mutation_p.S47F|LARGE_uc011ame.1_5'UTR|LARGE_uc011amf.1_Missense_Mutation_p.S47F	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	47	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GTGTGCCTGGGACTCCAGCGG	0.647													0	0	0	0.004672	0	3	34										A	34046621	G	A	34046621	3	1	72	1	0	0	0	0	1	0	0	0	8627	1174	41	1	2182	1	LARGE	22	34046621	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	12692267	34046621	17257945	200	22363										
EFCAB6	64800	broad.mit.edu	37	chr22	44068181	44068181	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ctgtacagggagatgtctttCtcatctaattgggaaagaga	11	6	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chr22:44068181C>G	uc003bdy.1	-	14	1639	c.1424G>C	c.(1423-1425)AGA>ACA	p.R475T	EFCAB6_uc003bdz.1_Missense_Mutation_p.R323T|EFCAB6_uc010gzi.1_Missense_Mutation_p.R323T|EFCAB6_uc010gzk.1_RNA	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	475					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGATGTCTTTCTCATCTAATT	0.294													0	0	0	0.009096	0	4	34										G	44068181	C	G	44068181	3	3	72	1	0	0	0	0	1	0	0	0	4939	913	32	1	3157	1	EFCAB6	22	44068181	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	10021560	44068181	7236385	201	22364										
CXorf23	256643	broad.mit.edu	37	chrX	19973521	19973521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ataccaacctttaacttgatGgattattgttatgatttcct	5	7	0	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:19973521G>A	uc004czp.2	-	4	1438	c.1438C>T	c.(1438-1440)CAT>TAT	p.H480Y	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.H45Y|CXorf23_uc004czo.2_Missense_Mutation_p.H430Y	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	480						mitochondrion				lung(1)|skin(1)	2						TTAACTTGATGGATTATTGTT	0.338													0	0	0	0.001984	0	6	50										A	19973521	G	A	19973521	3	1	72	1	0	0	0	0	1	0	0	0	4103	1348	47	2	642	2	CXorf23	23	19973521	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08		19973521	135297039	202	22365										
DCAF8L1	139425	broad.mit.edu	37	chrX	27998745	27998745	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tgacattaatatcgtgaccaCtctcaaagttcagtactggc	7	10	2	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:27998745C>A	uc004dbx.1	-	1	822	c.707G>T	c.(706-708)AGT>ATT	p.S236I		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	236										ovary(3)|skin(1)	4						ATCGTGACCACTCTCAAAGTT	0.517													1	0	2.74318e-10	0.006214	3.07327e-10	9	45										A	27998745	C	A	27998745	3	1	72	1	0	0	0	0	1	0	0	0	4277	565	20	4	1099	4	DCAF8L1	23	27998745	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	8025224	27998745	127271815	203	22366										
TAB3	257397	broad.mit.edu	37	chrX	30870918	30870918	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agggatcgcagtggtgcagcTgactcttctgagccgtctct	13	11	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:30870918T>A	uc004dcj.2	-	7	2350	c.1687A>T	c.(1687-1689)AGC>TGC	p.S563C	TAB3_uc004dck.2_Missense_Mutation_p.S563C|TAB3_uc010ngl.2_Missense_Mutation_p.S563C	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	563					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GTGGTGCAGCTGACTCTTCTG	0.458													0	0	0	0.014758	0	4	59										A	30870918	T	A	30870918	3	1	72	1	0	0	0	0	1	0	0	0	15494	1580	55	5	471	5	TAB3	23	30870918	Missense_Mutation	SNP	T	TCGA-FD-A3B3-01A-12D-A202-08	2872173	30870918	124399642	204	22367										
BCOR	54880	broad.mit.edu	37	chrX	39930940	39930940	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	actgtcctcttgtaatccttCcatctatgtaattaaaatgg	5	9	2	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:39930940C>T	uc004den.3	-	5	3293	c.3001G>A	c.(3001-3003)GAA>AAA	p.E1001K	BCOR_uc004dep.3_Missense_Mutation_p.E1001K|BCOR_uc004deo.3_Intron|BCOR_uc004dem.3_Missense_Mutation_p.E1001K	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1001					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGTAATCCTTCCATCTATGTA	0.303													0	0	0	0.004482	0	6	45										T	39930940	C	T	39930940	3	4	72	1	0	0	0	0	1	0	0	0	1386	864	30	1	2310	1	BCOR	23	39930940	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	9060022	39930940	115339620	205	22368										
HSD17B10	3028	broad.mit.edu	37	chrX	53459194	53459194	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ggagaacttccaaggccttaCatcaagaactcgctggaagt	10	10	1	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:53459194C>T	uc004dsl.1	-	3	388	c.357_splice	c.e3+1	p.D119_splice	HSD17B10_uc004dsm.1_Splice_Site_p.D119_splice	NM_004493	NP_004484	Q99714	HCD2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 10						branched chain family amino acid catabolic process|lipid metabolic process|tRNA processing	mitochondrial matrix|plasma membrane	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|3-hydroxyacyl-CoA dehydrogenase activity|cholate 7-alpha-dehydrogenase activity				0					NADH(DB00157)	CAAGGCCTTACATCAAGAACT	0.502													0	0	0	0.014758	0	4	17										T	53459194	C	T	53459194	5	4	72	1	0	0	0	0	0	0	1	0	7379	492	17	2	443	2	HSD17B10	23	53459194	Splice_Site	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	13528254	53459194	101811366	206	22369										
FAM120C	54954	broad.mit.edu	37	chrX	54185903	54185903	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtagtgaggttcttcccattCcagctcagtttcagagcatg	10	10	3	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:54185903C>G	uc004dsz.3	-	2	929	c.846G>C	c.(844-846)TGG>TGC	p.W282C	FAM120C_uc011moh.1_Missense_Mutation_p.W282C	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	282										ovary(1)|central_nervous_system(1)	2						TCTTCCCATTCCAGCTCAGTT	0.488													0	0	0	0.009096	0	4	89										G	54185903	C	G	54185903	3	3	72	1	0	0	0	0	1	0	0	0	5418	856	30	1	2504	1	FAM120C	23	54185903	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	726709	54185903	101084657	207	22370										
DLG3	1741	broad.mit.edu	37	chrX	69670626	69670626	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	atgtacgctccccctgactaCgccagcagtacgtactcatc	7	16	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:69670626C>T	uc004dyi.1	+	6	1306	c.978C>T	c.(976-978)TAC>TAT	p.Y326Y	DLG3_uc004dyj.1_5'Flank	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	326					axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					CCCCTGACTACGCCAGCAGTA	0.532													0	0	0	0.014758	0	4	55										T	69670626	C	T	69670626	2	4	72	1	0	0	0	0	0	0	0	1	4556	547	19	2		2	DLG3	23	69670626	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	15484723	69670626	85599934	208	22371										
TEX11	56159	broad.mit.edu	37	chrX	70080735	70080735	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	gtcgttgaatactttgttctGaggcaaatgaggcttcacac	10	8	2	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:70080735G>A	uc004dyl.2	-	6	503	c.341C>T	c.(340-342)TCA>TTA	p.S114L	TEX11_uc004dym.2_Missense_Mutation_p.S99L	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	114							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					ACTTTGTTCTGAGGCAAATGA	0.343													0	0	0	0.004672	0	3	24										A	70080735	G	A	70080735	3	1	72	1	0	0	0	0	1	0	0	0	15771	1294	45	1	2585	1	TEX11	23	70080735	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	410109	70080735	85189825	209	22372										
MED12	9968	broad.mit.edu	37	chrX	70346320	70346320	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tcagcatcagtggcctcatcGactttgccattcaggtgggg	12	11	4	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:70346320G>A	uc004dyy.2	+	19	2870	c.2671G>A	c.(2671-2673)GAC>AAC	p.D891N	MED12_uc011mpq.1_Missense_Mutation_p.D891N|MED12_uc004dyz.2_Missense_Mutation_p.D891N|MED12_uc004dza.2_Missense_Mutation_p.D738N	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	891					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGGCCTCATCGACTTTGCCAT	0.537													0	0	0	0.003163	0	11	136										A	70346320	G	A	70346320	3	1	72	1	0	0	0	0	1	0	0	0	9428	1058	37	1	2745	1	MED12	23	70346320	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	265585	70346320	84924240	210	22373										
ATRX	546	broad.mit.edu	37	chrX	76937566	76937566	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	ttgacttctcagcataatcaGataattcatccttcttttta	3	9	4	2			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:76937566G>C	uc004ecp.3	-	9	3414	c.3182C>G	c.(3181-3183)TCT>TGT	p.S1061C	ATRX_uc004ecq.3_Missense_Mutation_p.S1023C|ATRX_uc004eco.3_Missense_Mutation_p.S846C|ATRX_uc004ecr.2_Missense_Mutation_p.S993C|ATRX_uc010nlx.1_Missense_Mutation_p.S1032C|ATRX_uc010nly.1_Missense_Mutation_p.S1006C	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1061					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AGCATAATCAGATAATTCATC	0.333			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.008871	0	21	158										C	76937566	G	C	76937566	3	2	72	1	0	0	0	0	1	0	0	0	1208	942	33	1	4404	1	ATRX	23	76937566	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	6591246	76937566	78332994	211	22374										
MORC4	79710	broad.mit.edu	37	chrX	106221416	106221416	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	aagagaacccaaaggtgattCtcacctgcttattctgagaa	8	9	2	3			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:106221416C>T	uc004emu.3	-	8	1193	c.950G>A	c.(949-951)AGA>AAA	p.R317K	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.R317K|MORC4_uc004emw.3_Missense_Mutation_p.R65K	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	317							ATP binding|zinc ion binding			ovary(1)	1						AAAGGTGATTCTCACCTGCTT	0.378													0	0	0	0.016723	0	14	83										T	106221416	C	T	106221416	3	4	72	1	0	0	0	0	1	0	0	0	9704	913	32	1	1903	1	MORC4	23	106221416	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	29283850	106221416	49049144	212	22375										
IRS4	8471	broad.mit.edu	37	chrX	107978480	107978480	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agccagcctcccggctcgagCggcaccaagcccaggtgcct	12	18	0	0			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:107978480C>G	uc004eoc.2	-	1	1128	c.1095G>C	c.(1093-1095)CCG>CCC	p.P365P		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	365						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CCGGCTCGAGCGGCACCAAGC	0.637													0	0	0	0.004007	0	16	156										G	107978480	C	G	107978480	2	3	72	1	0	0	0	0	0	0	0	1	7842	755	27	4		4	IRS4	23	107978480	Silent	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	1757064	107978480	47292080	213	22376										
SAGE1	55511	broad.mit.edu	37	chrX	134993401	134993401	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agaagatgacaaatggccaaCaggcacctgataactccttg	9	10	0	4			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:134993401C>A	uc004ezh.2	+	17	2223	c.2056C>A	c.(2056-2058)CAG>AAG	p.Q686K	SAGE1_uc010nry.1_Missense_Mutation_p.Q655K|SAGE1_uc011mvv.1_Missense_Mutation_p.Q310K	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	686										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAATGGCCAACAGGCACCTGA	0.453													1	0	8.12818e-05	0.001984	8.70877e-05	6	78										A	134993401	C	A	134993401	3	1	72	1	0	0	0	0	1	0	0	0	13809	479	17	4	2118	4	SAGE1	23	134993401	Missense_Mutation	SNP	C	TCGA-FD-A3B3-01A-12D-A202-08	27014921	134993401	20277159	214	22377										
GPR50	9248	broad.mit.edu	37	chrX	150345317	150345317	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	tggttatcaccatcgttgtaGacctaatcggcaactccatg	8	11	1	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:150345317G>C	uc010ntg.1	+	1	259	c.124G>C	c.(124-126)GAC>CAC	p.D42H	uc004fes.1_RNA|GPR50_uc011myc.1_Missense_Mutation_p.D42H	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	42	Helical; Name=1; (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CATCGTTGTAGACCTAATCGG	0.507													0	0	0	0.010729	0	12	140										C	150345317	G	C	150345317	3	2	72	1	0	0	0	0	1	0	0	0	6697	942	33	1	126	1	GPR50	23	150345317	Missense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	15351916	150345317	4925243	215	22378										
TMLHE	55217	broad.mit.edu	37	chrX	154743794	154743794	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.356481481481481	77	5.01286269137013e-21	3.15357873210634	4.19441506240745	2.5893870764291	0.526938348960289	0.700881772669127	53	agaagctctggcaatctaccGatggaacttgggcttgctgg	13	9	2	1			TCGA-FD-A3B3-01A-12D-A202-08	TCGA-FD-A3B3-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8e9fb61d-c90d-440b-857a-12e1048435ea	7a00fec5-1f57-4aa2-891a-75c1ece8b60b	g.chrX:154743794G>T	uc004fnn.2	-	4	657	c.491C>A	c.(490-492)TCG>TAG	p.S164*	TMLHE_uc004fno.2_Nonsense_Mutation_p.S164*|TMLHE_uc004fnp.3_Nonsense_Mutation_p.S164*	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	164					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	GCAATCTACCGATGGAACTTG	0.433													1	0	0.00198382	0.001984	0.00208417	6	109										T	154743794	G	T	154743794	4	4	72	1	0	0	0	0	0	1	0	0	16229	1059	37	3	934	3	TMLHE	23	154743794	Nonsense_Mutation	SNP	G	TCGA-FD-A3B3-01A-12D-A202-08	4398477	154743794	526766	216	22379										
KLHL17	339451	broad.mit.edu	37	chr1	897016	897016	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gctgtccccgcagatgagatGagcgagagccgccagaccca	13	14	0	5			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:897016G>A	uc001aca.1	+	3	482	c.375G>A	c.(373-375)ATG>ATA	p.M125I	NOC2L_uc001abz.3_5'Flank|NOC2L_uc009vjq.2_5'Flank|NOC2L_uc009vjr.1_5'Flank|KLHL17_uc001acb.1_Missense_Mutation_p.M1I|KLHL17_uc010nya.1_Missense_Mutation_p.M1I|KLHL17_uc001acc.1_5'Flank|KLHL17_uc010nyb.1_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	125	BTB.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGATGAGATGAGCGAGAGCC	0.657													0	0	0	0.146539	0	16	5										A	897016	G	A	897016	3	1	73	1	0	0	0	0	1	0	0	0	8372	1290	45	1	385	1	KLHL17	1	897016	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		897016	248353605	1	22380										
TMEM57	55219	broad.mit.edu	37	chr1	25810749	25810749	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gccagcttcggcaggagaacGagctgctgcagaacaagtac	13	11	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:25810749G>A	uc001bkk.2	+	7	1499	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	TMEM57_uc009vru.2_Missense_Mutation_p.E206K|TMEM57_uc009vrv.2_Missense_Mutation_p.E75K	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	433						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGAGAACGAGCTGCTGCA	0.572													0	0	0	0.27861	0	7	47										A	25810749	G	A	25810749	3	1	73	1	0	0	0	0	1	0	0	0	16181	1059	37	1	1323	1	TMEM57	1	25810749	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	24913733	25810749	223439872	2	22381										
MANEAL	149175	broad.mit.edu	37	chr1	38265863	38265863	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttcatcaaagagaaggagcaGtggctcatgtgaggggcctg	15	7	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:38265863G>T	uc001cby.2	+	4	1443	c.1362G>T	c.(1360-1362)CAG>CAT	p.Q454H	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.Q232H	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	454	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGAAGGAGCAGTGGCTCATGT	0.587													1	0	1.99824e-07	0.160694	2.11934e-07	16	122										T	38265863	G	T	38265863	3	4	73	1	0	0	0	0	1	0	0	0	9222	1020	36	4	1376	4	MANEAL	1	38265863	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	12455114	38265863	210984758	3	22382										
INPP5B	3633	broad.mit.edu	37	chr1	38332195	38332195	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcaaattctgacctcaggccTggttgctgaaacagatcttc	8	11	4	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:38332195T>A	uc001ccg.1	-	21	2416	c.2322A>T	c.(2320-2322)CCA>CCT	p.P774P	INPP5B_uc009vvk.1_Intron|INPP5B_uc001ccf.1_Silent_p.P610P	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	854	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ACCTCAGGCCTGGTTGCTGAA	0.363													0	0	0	0.175082	0	16	118										A	38332195	T	A	38332195	2	1	73	1	0	0	0	0	0	0	0	1	7755	1567	55	5		5	INPP5B	1	38332195	Silent	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08	66332	38332195	210918426	4	22383										
FOXE3	2301	broad.mit.edu	37	chr1	47882237	47882237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcgcgctcatcgccatggctCtggcgcacgccccgggccgc	13	19	2	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:47882237C>G	uc001crk.2	+	1	494	c.250C>G	c.(250-252)CTG>GTG	p.L84V		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	84	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		CGCCATGGCTCTGGCGCACGC	0.512													0	0	0	0.307466	0	9	22										G	47882237	C	G	47882237	3	3	73	1	0	0	0	0	1	0	0	0	6004	912	32	1	252	1	FOXE3	1	47882237	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	9550042	47882237	201368384	5	22384										
ROR1	4919	broad.mit.edu	37	chr1	64605962	64605962	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcctggagaatgtcctgtgtCaaacagagtacatttttgca	9	8	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:64605962C>T	uc001dbj.2	+	6	1180	c.781C>T	c.(781-783)CAA>TAA	p.Q261*	ROR1_uc001dbi.3_Nonsense_Mutation_p.Q261*|uc001dbl.2_Intron	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	261	FZ.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TGTCCTGTGTCAAACAGAGTA	0.498													0	0	0	0.323286	0	83	81										T	64605962	C	T	64605962	4	4	73	1	0	0	0	0	0	1	0	0	13526	827	29	1	803	1	ROR1	1	64605962	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	16723725	64605962	184644659	6	22385										
MTF2	22823	broad.mit.edu	37	chr1	93602319	93602319	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aagaggtcgtcttccaagaaGagcactccagactcagaact	9	11	2	5			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:93602319G>C	uc009wdj.2	+	15	1809	c.1517G>C	c.(1516-1518)AGA>ACA	p.R506T	MTF2_uc010oth.1_Missense_Mutation_p.R404T|MTF2_uc009wdk.2_Missense_Mutation_p.R449T|MTF2_uc001dpi.3_Missense_Mutation_p.R233T|MTF2_uc010oti.1_Missense_Mutation_p.R404T|MTF2_uc001dpj.3_Missense_Mutation_p.R404T|MTF2_uc001dpl.3_Missense_Mutation_p.R404T|MTF2_uc001dpm.3_Missense_Mutation_p.R175T	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	506						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		CTTCCAAGAAGAGCACTCCAG	0.403													0	0	0	0.203993	0	33	59										C	93602319	G	C	93602319	3	2	73	1	0	0	0	0	1	0	0	0	9923	942	33	1	1575	1	MTF2	1	93602319	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	28996357	93602319	155648302	7	22386										
HIAT1	64645	broad.mit.edu	37	chr1	100534050	100534050	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccttaaaaaaagtcggccaaGattccatagtgctgctgatc	8	10	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:100534050G>C	uc001dst.2	+	7	727	c.727G>C	c.(727-729)GAT>CAT	p.D243H		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	243	Extracellular (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		AGTCGGCCAAGATTCCATAGT	0.383													0	0	0	0.153744	0	28	66										C	100534050	G	C	100534050	3	2	73	1	0	0	0	0	1	0	0	0	7097	942	33	1	753	1	HIAT1	1	100534050	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	6931731	100534050	148716571	8	22387										
COL11A1	1301	broad.mit.edu	37	chr1	103431095	103431095	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ggccggtcttgccttgaaatCcctaaggaggcaaagtatta	11	9	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:103431095C>T	uc001dul.2	-	38	3182	c.2864G>A	c.(2863-2865)GGA>GAA	p.G955E	COL11A1_uc001duk.2_Missense_Mutation_p.G151E|COL11A1_uc001dum.2_Missense_Mutation_p.G967E|COL11A1_uc001dun.2_Missense_Mutation_p.G916E|COL11A1_uc009weh.2_Missense_Mutation_p.G839E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	955	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCCTTGAAATCCCTAAGGAGG	0.388													0	0	0	0.323286	0	53	72										T	103431095	C	T	103431095	3	4	73	1	0	0	0	0	1	0	0	0	3667	869	30	1	2676	1	COL11A1	1	103431095	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	2897045	103431095	145819526	9	22388										
PSRC1	84722	broad.mit.edu	37	chr1	109824459	109824459	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcggcgaggccccaggccctCgcctgcgctctcccgatcct	11	20	1	0	rs144416204		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:109824459C>T	uc001dxg.2	-	4	423	c.301G>A	c.(301-303)GAG>AAG	p.E101K	PSRC1_uc001dxb.2_5'UTR|PSRC1_uc001dxc.2_Missense_Mutation_p.E101K|PSRC1_uc001dxd.2_Missense_Mutation_p.E101K|PSRC1_uc001dxe.2_Missense_Mutation_p.E101K|PSRC1_uc001dxf.2_Missense_Mutation_p.E101K|PSRC1_uc001dxh.2_Missense_Mutation_p.E101K|PSRC1_uc001dxi.2_Missense_Mutation_p.E101K|PSRC1_uc001dxj.2_Missense_Mutation_p.E101K	NM_001032290	NP_001027461	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1 isoform c	101					cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding				0		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		CCCAGGCCCTCGCCTGCGCTC	0.647													0	0	0	0.234183	0	19	23										T	109824459	C	T	109824459	3	4	73	1	0	0	0	0	1	0	0	0	12719	893	31	1	781	1	PSRC1	1	109824459	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	6393364	109824459	139426162	10	22389										
C1orf43	25912	broad.mit.edu	37	chr1	154180113	154180113	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtcgctgagagctcccaattCgtgctttaaccctgaagaac	9	12	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:154180113C>T	uc001fei.2	-	7	968	c.578G>A	c.(577-579)CGA>CAA	p.R193Q	C1orf189_uc001fee.1_5'Flank|C1orf43_uc001fef.1_Missense_Mutation_p.R90Q|C1orf43_uc001feg.2_Missense_Mutation_p.R159Q|C1orf43_uc001feh.2_Missense_Mutation_p.R141Q|C1orf43_uc001fej.2_Missense_Mutation_p.R175Q|C1orf43_uc009wos.1_3'UTR	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	193						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					GCTCCCAATTCGTGCTTTAAC	0.507													0	0	0	0.294199	0	20	64										T	154180113	C	T	154180113	3	4	73	1	0	0	0	0	1	0	0	0	2040	884	31	1	187	1	C1orf43	1	154180113	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	44355654	154180113	95070508	11	22390										
RGS5	8490	broad.mit.edu	37	chr1	163131761	163131761	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	actgcagggcctcgtccagcGaggttctacatcaataataa	9	11	2	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:163131761G>C	uc001gcn.2	-	3	408	c.161C>G	c.(160-162)TCG>TGG	p.S54W	RGS5_uc009wvb.2_Intron	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	54					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			CTCGTCCAGCGAGGTTCTACA	0.428													0	0	0	0.307466	0	6	48										C	163131761	G	C	163131761	3	2	73	1	0	0	0	0	1	0	0	0	13308	1059	37	1	396	1	RGS5	1	163131761	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	8951648	163131761	86118860	12	22391										
POGK	57645	broad.mit.edu	37	chr1	166818581	166818581	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cgggcattccgaggccccaaGaatgggaggtttgctctggt	15	10	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:166818581G>A	uc001gdt.1	+	5	885	c.765G>A	c.(763-765)AAG>AAA	p.K255K	POGK_uc010ple.1_Silent_p.K170K|POGK_uc010plf.1_Silent_p.K137K	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	255	HTH CENPB-type.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GAGGCCCCAAGAATGGGAGGT	0.567													0	0	0	0.173368	0	29	21										A	166818581	G	A	166818581	2	1	73	1	0	0	0	0	0	0	0	1	12185	933	33	1		1	POGK	1	166818581	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	3686820	166818581	82432040	13	22392										
POU2F1	5451	broad.mit.edu	37	chr1	167365643	167365643	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcaagttgaagccacttttaGagaagtggctaaatgatgca	11	6	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:167365643G>C	uc001gec.2	+	11	1201	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Missense_Mutation_p.E345Q|POU2F1_uc001gee.2_Missense_Mutation_p.E347Q|POU2F1_uc010plh.1_Missense_Mutation_p.E284Q|POU2F1_uc001gef.2_Missense_Mutation_p.E359Q|POU2F1_uc001geg.2_Missense_Mutation_p.E245Q|POU2F1_uc009wvg.1_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	347	POU-specific.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						GCCACTTTTAGAGAAGTGGCT	0.368													0	0	0	0.144211	0	26	78										C	167365643	G	C	167365643	3	2	73	1	0	0	0	0	1	0	0	0	12271	943	33	1	1073	1	POU2F1	1	167365643	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	547062	167365643	81884978	14	22393										
PRRX1	5396	broad.mit.edu	37	chr1	170688895	170688895	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctgaactcagaagaaaaaaaGaagagaaagcagcgaaggaa	11	5	1	5			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:170688895G>T	uc001ghf.2	+	2	317	c.270G>T	c.(268-270)AAG>AAT	p.K90N	PRRX1_uc001ghe.2_Missense_Mutation_p.K90N	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	90						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAGAAAAAAAGAAGAGAAAGC	0.433													1	0	5.18039e-06	0.27861	5.38556e-06	7	22										T	170688895	G	T	170688895	3	4	73	1	0	0	0	0	1	0	0	0	12612	933	33	3	276	3	PRRX1	1	170688895	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	3323252	170688895	78561726	15	22394										
PRRX1	5396	broad.mit.edu	37	chr1	170688965	170688965	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aggctttggagcgtgtctttGagcggacacactatcctgat	12	9	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:170688965G>A	uc001ghf.2	+	2	387	c.340G>A	c.(340-342)GAG>AAG	p.E114K	PRRX1_uc001ghe.2_Missense_Mutation_p.E114K	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	114	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCGTGTCTTTGAGCGGACACA	0.522													0	0	0	0.204396	0	15	65										A	170688965	G	A	170688965	3	1	73	1	0	0	0	0	1	0	0	0	12612	1291	45	1	346	1	PRRX1	1	170688965	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	70	170688965	78561656	16	22395										
CEP350	9857	broad.mit.edu	37	chr1	179965793	179965793	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	actgagagcggtaactggatGataggcagtcgagaagaacg	15	6	0	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:179965793G>A	uc001gnt.2	+	6	884	c.501G>A	c.(499-501)ATG>ATA	p.M167I	CEP350_uc001gnr.1_Missense_Mutation_p.M141I|CEP350_uc009wxl.2_Missense_Mutation_p.M166I|CEP350_uc001gnu.2_Missense_Mutation_p.M1I	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	167						centrosome|nucleus|spindle				ovary(4)	4						GTAACTGGATGATAGGCAGTC	0.418													0	0	0	0.189662	0	19	15										A	179965793	G	A	179965793	3	1	73	1	0	0	0	0	1	0	0	0	3254	1290	45	1	519	1	CEP350	1	179965793	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	9276828	179965793	69284828	17	22396										
DHX9	1660	broad.mit.edu	37	chr1	182849629	182849630	+	Splice_Site	INS	-	-	A													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acaaagaactatctccccacINSagagcttgatgcattagatg							TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:182849629_182849630insA	uc001gpr.2	+	22	2676	c.2513_splice	c.e22-2	p.E838_splice	DHX9_uc001gps.2_Splice_Site_p.E624_splice|DHX9_uc001gpt.2_Splice_Site_p.E117_splice|DHX9_uc009wyd.2_5'Flank	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9						CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TATCTCCCCACAGAGCTTGATG	0.396																		13	61	---	---								A	182849630	-	A	182849629	8	5	73	1	0	1	1	0	0	0	1	0	4516	493	17	0		0	DHX9	1	182849629	Splice_Site	INS	-	TCGA-FD-A3B5-01A-11D-A20D-08	2883836	182849629	66400992	18	22397										
CDC42BPA	8476	broad.mit.edu	37	chr1	227307535	227307535	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcttctctttcttgttgtaaCgttttgatttgtttttcata	5	6	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:227307535C>T	uc001hqr.2	-	12	2560	c.1617G>A	c.(1615-1617)ACG>ACA	p.T539T	CDC42BPA_uc001hqs.2_Silent_p.T539T|CDC42BPA_uc009xes.2_Silent_p.T539T|CDC42BPA_uc010pvs.1_Silent_p.T539T	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	539	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTTGTTGTAACGTTTTGATTT	0.308													0	0	0	0.115264	0	3	18										T	227307535	C	T	227307535	2	4	73	1	0	0	0	0	0	0	0	1	3072	523	19	2		2	CDC42BPA	1	227307535	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	44457906	227307535	21943086	19	22398										
LYST	1130	broad.mit.edu	37	chr1	235907429	235907429	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gttacattttctggagttctCaaaatgtcaataatgtctga	7	6	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:235907429C>G	uc001hxj.2	-	30	8176	c.8001G>C	c.(7999-8001)TTG>TTC	p.L2667F	LYST_uc009xga.1_Missense_Mutation_p.L303F	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2667					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTGGAGTTCTCAAAATGTCAA	0.294									Chediak-Higashi_syndrome				0	0	0	0.248553	0	7	65										G	235907429	C	G	235907429	3	3	73	1	0	0	0	0	1	0	0	0	9128	825	29	1	3500	1	LYST	1	235907429	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	8599894	235907429	13343192	20	22399										
LYST	1130	broad.mit.edu	37	chr1	235907458	235907458	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aataatgtctgaattaaattCtttgaattgaaaaaaagaat	5	2	2	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:235907458C>G	uc001hxj.2	-	30	8148	c.7973_splice	c.e30-1	p.E2658_splice	LYST_uc009xga.1_Splice_Site_p.E294_splice	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GAATTAAATTCTTTGAATTGA	0.264									Chediak-Higashi_syndrome				0	0	0	0.150653	0	4	47										G	235907458	C	G	235907458	5	3	73	1	0	0	0	0	0	0	1	0	9128	927	32	1	3529	1	LYST	1	235907458	Splice_Site	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	29	235907458	13343163	21	22400										
GEN1	348654	broad.mit.edu	37	chr2	17941319	17941319	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atctgagtctctgggtgtgtGaggcacagacagtcaaaaaa	12	7	3	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:17941319G>A	uc002rct.2	+	2	182	c.109G>A	c.(109-111)GAG>AAG	p.E37K	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.E37K|GEN1_uc002rcu.2_Missense_Mutation_p.E37K	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	37	N-domain.				DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTGGGTGTGTGAGGCACAGAC	0.433								Homologous_recombination					0	0	0	0.080935	0	11	85										A	17941319	G	A	17941319	3	1	73	1	0	0	0	0	1	0	0	0	6335	1291	45	1	111	1	GEN1	2	17941319	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		17941319	225258054	22	22401										
PREPL	9581	broad.mit.edu	37	chr2	44548554	44548554	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ggtgctgtcaagtccaagttCctcgtacaggaatttaattt	9	8	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:44548554C>G	uc002ruf.2	-	14	2160	c.2125G>C	c.(2125-2127)GAA>CAA	p.E709Q	PREPL_uc002rug.2_Missense_Mutation_p.E643Q|PREPL_uc002ruh.2_Missense_Mutation_p.E647Q|PREPL_uc010fax.2_Missense_Mutation_p.E709Q|PREPL_uc002rui.3_Missense_Mutation_p.E620Q|PREPL_uc002ruj.1_Missense_Mutation_p.E620Q|PREPL_uc002ruk.1_Missense_Mutation_p.E709Q	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	709					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGTCCAAGTTCCTCGTACAGG	0.348													0	0	0	0.324025	0	24	12										G	44548554	C	G	44548554	3	3	73	1	0	0	0	0	1	0	0	0	12475	864	30	1	62	1	PREPL	2	44548554	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	26607235	44548554	198650819	23	22402										
CIAO1	9391	broad.mit.edu	37	chr2	96933152	96933152	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctgcggtaattacctggcctCtgccagctttgatgctacca	9	13	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:96933152C>T	uc002svs.2	+	2	438	c.233C>T	c.(232-234)TCT>TTT	p.S78F	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	78	WD 2.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						TACCTGGCCTCTGCCAGCTTT	0.547													0	0	0	0.160694	0	13	120										T	96933152	C	T	96933152	3	4	73	1	0	0	0	0	1	0	0	0	3418	913	32	1	239	1	CIAO1	2	96933152	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	52384598	96933152	146266221	24	22403										
SCN1A	6323	broad.mit.edu	37	chr2	166908238	166908238	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ataattcttacttgaatcttGaatatatgacttccagtcaa	4	7	3	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:166908238G>C	uc010zcz.1	-	6	973	c.955C>G	c.(955-957)CAA>GAA	p.Q319E	SCN1A_uc002udo.3_Missense_Mutation_p.Q188E|SCN1A_uc010fpk.2_Missense_Mutation_p.Q188E	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	319	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTTGAATCTTGAATATATGAC	0.174													0	0	0	0.217242	0	5	21										C	166908238	G	C	166908238	3	2	73	1	0	0	0	0	1	0	0	0	13914	1299	45	1	5158	1	SCN1A	2	166908238	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	69975086	166908238	76291135	25	22404										
AGPS	8540	broad.mit.edu	37	chr2	178362475	178362475	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcatttttggacggattaaaAaagttttatattacaaaggt	7	3	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:178362475A>G	uc002ull.2	+	13	1391	c.1344A>G	c.(1342-1344)AAA>AAG	p.K448K	AGPS_uc010zfb.1_Silent_p.K358K	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	448					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			ACGGATTAAAAAAGTTTTATA	0.279													0	0	0	0.058154	0	8	5										G	178362475	A	G	178362475	2	3	73	1	0	0	0	0	0	0	0	1	394	11	1	5		5	AGPS	2	178362475	Silent	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	11454237	178362475	64836898	26	22405										
NCKAP1	10787	broad.mit.edu	37	chr2	183868005	183868005	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgtgaagtaatataatgccaGatttttcagaatctctgatt	7	5	2	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:183868005G>C	uc002upc.2	-	3	670	c.268C>G	c.(268-270)CTG>GTG	p.L90V	NCKAP1_uc002upb.2_Missense_Mutation_p.L96V	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	90					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TATAATGCCAGATTTTTCAGA	0.254													0	0	0	0.27861	0	7	31										C	183868005	G	C	183868005	3	2	73	1	0	0	0	0	1	0	0	0	10221	933	33	1	3234	1	NCKAP1	2	183868005	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	5505530	183868005	59331368	27	22406										
STK36	27148	broad.mit.edu	37	chr2	219549924	219549924	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gacttctgccagcgcatccaGagtcagctgcatgaagctgg	12	12	2	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:219549924G>C	uc002viu.2	+	11	1619	c.1353G>C	c.(1351-1353)CAG>CAC	p.Q451H	STK36_uc002viv.2_Missense_Mutation_p.Q451H	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	451					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		AGCGCATCCAGAGTCAGCTGC	0.507													0	0	0	0.204396	0	17	42										C	219549924	G	C	219549924	3	2	73	1	0	0	0	0	1	0	0	0	15301	933	33	1	1391	1	STK36	2	219549924	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	35681919	219549924	23649449	28	22407										
CHRNG	1146	broad.mit.edu	37	chr2	233409214	233409214	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	actggggaggaggtggccctCtgcctgcctcgcagtgaact	15	12	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:233409214C>G	uc002vsx.1	+	10	1194	c.1173C>G	c.(1171-1173)CTC>CTG	p.L391L	CHRNG_uc010fye.1_Silent_p.L339L	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	391	Cytoplasmic (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		AGGTGGCCCTCTGCCTGCCTC	0.662													0	0	0	0.323286	0	55	23										G	233409214	C	G	233409214	2	3	73	1	0	0	0	0	0	0	0	1	3396	900	32	1		1	CHRNG	2	233409214	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	13859290	233409214	9790159	29	22408										
CAPN7	23473	broad.mit.edu	37	chr3	15283750	15283750	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aagactgatgggaaaaaagtTtattacccaggtatgtttag	10	4	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:15283750T>G	uc003bzn.2	+	16	2124	c.1854T>G	c.(1852-1854)GTT>GTG	p.V618V		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	calpain 7	618	Domain III.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1						GGAAAAAAGTTTATTACCCAG	0.279													0	0	0	0.27861	0	8	48										G	15283750	T	G	15283750	2	3	73	1	0	0	0	0	0	0	0	1	2631	1828	64	5		5	CAPN7	3	15283750	Silent	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08		15283750	182738680	30	22409										
ZNF501	115560	broad.mit.edu	37	chr3	44776196	44776196	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aaacaaaagcaattcttgttCagcatctgagaattcatact	5	8	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:44776196C>T	uc003cnu.1	+	3	684	c.283C>T	c.(283-285)CAG>TAG	p.Q95*	ZNF501_uc003cnv.1_Nonsense_Mutation_p.Q95*	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	95	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		AATTCTTGTTCAGCATCTGAG	0.368													0	0	0	0.324025	0	22	92										T	44776196	C	T	44776196	4	4	73	1	0	0	0	0	0	1	0	0	17946	827	29	1	285	1	ZNF501	3	44776196	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	29492446	44776196	153246234	31	22410										
MAGI1	9223	broad.mit.edu	37	chr3	65367599	65367599	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgagattgacgtggccttgcTtggcagcttgttgcataagc	13	8	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:65367599T>C	uc003dmn.2	-	16	3180	c.2654A>G	c.(2653-2655)AAG>AGG	p.K885R	MAGI1_uc003dmm.2_Missense_Mutation_p.K913R|MAGI1_uc003dmo.2_Missense_Mutation_p.K913R|MAGI1_uc003dmp.2_Missense_Mutation_p.K885R|MAGI1_uc003dmq.1_5'Flank|MAGI1_uc010hnx.1_Missense_Mutation_p.K196R	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	913					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GTGGCCTTGCTTGGCAGCTTG	0.483													0	0	0	0.116897	0	27	33										C	65367599	T	C	65367599	3	2	73	1	0	0	0	0	1	0	0	0	9190	1609	56	5	1912	5	MAGI1	3	65367599	Missense_Mutation	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08	20591403	65367599	132654831	32	22411										
PHLDB2	90102	broad.mit.edu	37	chr3	111685499	111685499	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gctagaatagaagaaatggaGagacttttgaagcaggctca	12	5	1	5			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:111685499G>C	uc010hqa.2	+	14	3528	c.3117G>C	c.(3115-3117)GAG>GAC	p.E1039D	PHLDB2_uc003dyc.2_Missense_Mutation_p.E1023D|PHLDB2_uc003dyd.2_Missense_Mutation_p.E996D|PHLDB2_uc003dyg.2_Missense_Mutation_p.E1039D|PHLDB2_uc003dyh.2_Missense_Mutation_p.E996D|PHLDB2_uc003dyi.2_Missense_Mutation_p.E530D|PHLDB2_uc003dyj.2_Missense_Mutation_p.E94D	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1039	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AAGAAATGGAGAGACTTTTGA	0.418													0	0	0	0.323286	0	47	40										C	111685499	G	C	111685499	3	2	73	1	0	0	0	0	1	0	0	0	11852	933	33	1	3252	1	PHLDB2	3	111685499	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	46317900	111685499	86336931	33	22412										
C3orf17	25871	broad.mit.edu	37	chr3	112724558	112724558	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtatgacaggcattgaaactCcactattcaagagctgctta	8	9	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:112724558C>G	uc003dzr.2	-	9	1590	c.1529G>C	c.(1528-1530)GGA>GCA	p.G510A	GTPBP8_uc011bhy.1_Intron|C3orf17_uc003dzq.2_Missense_Mutation_p.G135A|C3orf17_uc011bhz.1_Missense_Mutation_p.G135A|C3orf17_uc010hqh.2_Missense_Mutation_p.G135A|C3orf17_uc003dzt.2_Missense_Mutation_p.G413A|C3orf17_uc003dzs.2_Missense_Mutation_p.G374A|C3orf17_uc010hqg.2_Missense_Mutation_p.G335A|C3orf17_uc011bia.1_Missense_Mutation_p.G307A|C3orf17_uc003dzu.2_Missense_Mutation_p.G439A|C3orf17_uc011bib.1_Missense_Mutation_p.G399A|C3orf17_uc011bic.1_Missense_Mutation_p.G343A|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	510						integral to membrane					0						CATTGAAACTCCACTATTCAA	0.413													0	0	0	0.26419	0	19	75										G	112724558	C	G	112724558	3	3	73	1	0	0	0	0	1	0	0	0	2210	855	30	1	178	1	C3orf17	3	112724558	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	1039059	112724558	85297872	34	22413										
ATP6V1A	523	broad.mit.edu	37	chr3	113499971	113499971	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gccacagcgaattggttggaGagattattcgattggagggt	15	5	0	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:113499971G>C	uc003eao.2	+	3	223	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	ATP6V1A_uc011bik.1_Missense_Mutation_p.E20Q	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	53					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						ATTGGTTGGAGAGATTATTCG	0.433													0	0	0	0.323286	0	62	60										C	113499971	G	C	113499971	3	2	73	1	0	0	0	0	1	0	0	0	1177	943	33	1	163	1	ATP6V1A	3	113499971	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	775413	113499971	84522459	35	22414										
PLA1A	51365	broad.mit.edu	37	chr3	119327641	119327641	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttaggaacaaagccttcctgGattgacacatttattagaac	7	8	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:119327641G>C	uc003ecu.2	+	3	339	c.300G>C	c.(298-300)TGG>TGC	p.W100C	PLA1A_uc003ecv.2_Missense_Mutation_p.W100C|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_5'UTR	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	100					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AGCCTTCCTGGATTGACACAT	0.423													0	0	0	0.279185	0	34	113										C	119327641	G	C	119327641	3	2	73	1	0	0	0	0	1	0	0	0	11988	1183	41	1	310	1	PLA1A	3	119327641	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	5827670	119327641	78694789	36	22415										
CPA3	1359	broad.mit.edu	37	chr3	148601417	148601417	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cagccattcctaacaccaatGacccatgtgcagataactat	5	13	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:148601417G>A	uc003ewm.2	+	9	848	c.796G>A	c.(796-798)GAC>AAC	p.D266N		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	266					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAACACCAATGACCCATGTGC	0.458													0	0	0	0.150653	0	4	69										A	148601417	G	A	148601417	3	1	73	1	0	0	0	0	1	0	0	0	3791	1290	45	1	830	1	CPA3	3	148601417	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	29273776	148601417	49421013	37	22416										
LRRC31	79782	broad.mit.edu	37	chr3	169558008	169558008	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgaggaaccgcacgttttggCagaacatggtccaccccgca	11	13	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:169558008C>A	uc003fgc.1	-	9	1498	c.1421G>T	c.(1420-1422)TGC>TTC	p.C474F	LRRC31_uc010hwp.1_Missense_Mutation_p.C418F	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	474	LRR 9.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CACGTTTTGGCAGAACATGGT	0.468													1	0	4.3838e-07	0.105934	4.62612e-07	12	73										A	169558008	C	A	169558008	3	1	73	1	0	0	0	0	1	0	0	0	8986	710	25	4	241	4	LRRC31	3	169558008	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	20956591	169558008	28464422	38	22417										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.069234	0	10	42										A	178936091	G	A	178936091	3	1	73	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	9378083	178936091	19086339	39	22418										
USP13	8975	broad.mit.edu	37	chr3	179458119	179458119	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tctcctctaacaggcagcaaGatgcccaggaattcttcttg	8	12	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:179458119G>A	uc003fkh.2	+	11	1420	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	USP13_uc003fkf.2_Missense_Mutation_p.D447N	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	447					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			CAGGCAGCAAGATGCCCAGGA	0.507													0	0	0	0.249174	0	21	80										A	179458119	G	A	179458119	3	1	73	1	0	0	0	0	1	0	0	0	17041	942	33	1	1381	1	USP13	3	179458119	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	522028	179458119	18564311	40	22419										
DNAJB11	51726	broad.mit.edu	37	chr3	186289895	186289895	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acttcccagacgagatttctAtaagatcttgggggtgcctc	10	10	2	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:186289895A>G	uc003fqi.2	+	2	300	c.80A>G	c.(79-81)TAT>TGT	p.Y27C	TBCCD1_uc011bry.1_5'Flank|TBCCD1_uc003fqh.2_5'Flank	NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	27	J.				protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		CGAGATTTCTATAAGATCTTG	0.393													0	0	0	0.214465	0	29	22										G	186289895	A	G	186289895	3	3	73	1	0	0	0	0	1	0	0	0	4616	449	16	5	86	5	DNAJB11	3	186289895	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	6831776	186289895	11732535	41	22420										
TMEM44	93109	broad.mit.edu	37	chr3	194309273	194309273	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aggtgttaatcatcatcactCaggtgtgctgtcctcacaga	9	10	5	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:194309273C>G	uc010hzn.2	-	11	1582	c.1413G>C	c.(1411-1413)CTG>CTC	p.L471L	TMEM44_uc010hzm.2_3'UTR|TMEM44_uc003fuc.2_Silent_p.L156L|TMEM44_uc003fue.2_Silent_p.L424L|TMEM44_uc003fud.2_Silent_p.L435L|TMEM44_uc003fuf.2_3'UTR|TMEM44_uc011bsv.1_Silent_p.L434L|uc003fug.2_5'Flank	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	471	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CATCATCACTCAGGTGTGCTG	0.532													0	0	0	0.268233	0	40	38										G	194309273	C	G	194309273	2	3	73	1	0	0	0	0	0	0	0	1	16165	813	29	1		1	TMEM44	3	194309273	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	8019378	194309273	3713157	42	22421										
EVC2	132884	broad.mit.edu	37	chr4	5633750	5633750	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccgcagaaggttgctgcactCtacagcagactggagagagg	14	10	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:5633750C>G	uc003gij.2	-	11	1534	c.1480G>C	c.(1480-1482)GAG>CAG	p.E494Q	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.E414Q	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	494	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						TTGCTGCACTCTACAGCAGAC	0.398													0	0	0	0.058154	0	8	47										G	5633750	C	G	5633750	3	3	73	1	0	0	0	0	1	0	0	0	5286	922	32	1	2494	1	EVC2	4	5633750	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		5633750	185520526	43	22422										
TBC1D1	23216	broad.mit.edu	37	chr4	38091654	38091654	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aggaaaagaaaaggacatctCgtgagctccgagagctgtgg	14	7	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:38091654C>T	uc003gtb.2	+	13	2495	c.2152C>T	c.(2152-2154)CGT>TGT	p.R718C	TBC1D1_uc011byd.1_Missense_Mutation_p.R812C|TBC1D1_uc010ifd.2_Missense_Mutation_p.R505C|TBC1D1_uc011byf.1_Missense_Mutation_p.R589C	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	718						nucleus	Rab GTPase activator activity			ovary(1)	1						AAGGACATCTCGTGAGCTCCG	0.488													0	0	0	0.160694	0	17	52										T	38091654	C	T	38091654	3	4	73	1	0	0	0	0	1	0	0	0	15594	884	31	1	2198	1	TBC1D1	4	38091654	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	32457904	38091654	153062622	44	22423										
GABRA4	2557	broad.mit.edu	37	chr4	46979532	46979532	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cattcctgaagaaagtatcaGgggtccacactttcgttacc	8	11	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:46979532G>A	uc003gxg.2	-	4	528	c.389C>T	c.(388-390)CCT>CTT	p.P130L		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	130	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAAAGTATCAGGGGTCCACAC	0.348													0	0	0	0.144211	0	32	33										A	46979532	G	A	46979532	3	1	73	1	0	0	0	0	1	0	0	0	6163	1000	35	2	1299	2	GABRA4	4	46979532	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	8887878	46979532	144174744	45	22424										
CLGN	1047	broad.mit.edu	37	chr4	141327104	141327104	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agcaacacttactgaactatCaagggtttatcagcaaaaat	6	8	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:141327104C>G	uc011chi.1	-	6	629	c.411G>C	c.(409-411)TTG>TTC	p.L137F	CLGN_uc003iii.2_Missense_Mutation_p.L137F	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	137	Lumenal (Potential).				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					ACTGAACTATCAAGGGTTTAT	0.333													0	0	0	0.069234	0	8	49										G	141327104	C	G	141327104	3	3	73	1	0	0	0	0	1	0	0	0	3524	825	29	1	1465	1	CLGN	4	141327104	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	94347572	141327104	49827172	46	22425										
ZNF827	152485	broad.mit.edu	37	chr4	146824287	146824287	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gacttccccataggatgcttCtgacggagtctctgaagagt	11	10	2	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:146824287C>A	uc003ikn.2	-	2	172	c.124G>T	c.(124-126)GAA>TAA	p.E42*	ZNF827_uc003ikm.2_Nonsense_Mutation_p.E42*|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	42					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TAGGATGCTTCTGACGGAGTC	0.532													1	0	1.3612e-06	0.132662	1.42926e-06	11	93										A	146824287	C	A	146824287	4	1	73	1	0	0	0	0	0	1	0	0	18177	922	32	3	3157	3	ZNF827	4	146824287	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	5497183	146824287	44329989	47	22426										
NR3C2	4306	broad.mit.edu	37	chr4	149073667	149073667	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tagagaaattggctgttcgtAtgtttgtacgatctccagct	10	7	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:149073667A>G	uc003ilj.3	-	6	2797	c.2463T>C	c.(2461-2463)CAT>CAC	p.H821H	NR3C2_uc003ilk.3_Silent_p.H704H|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	821	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGCTGTTCGTATGTTTGTACG	0.368													0	0	0	0.27861	0	7	81										G	149073667	A	G	149073667	2	3	73	1	0	0	0	0	0	0	0	1	10631	446	16	5		5	NR3C2	4	149073667	Silent	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	2249380	149073667	42080609	48	22427										
DCLK2	166614	broad.mit.edu	37	chr4	151141909	151141909	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	taaacggtggacctgagcttGaccgttgcataagtcctgaa	11	9	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:151141909G>T	uc003ilm.3	+	6	1211	c.1111G>T	c.(1111-1113)GAC>TAC	p.D371Y	DCLK2_uc003iln.3_Missense_Mutation_p.D370Y|DCLK2_uc003ilo.3_Missense_Mutation_p.D388Y|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	371					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					ACCTGAGCTTGACCGTTGCAT	0.413													1	0	1.76689e-08	0.058154	1.88349e-08	8	18										T	151141909	G	T	151141909	3	4	73	1	0	0	0	0	1	0	0	0	4292	1290	45	3	1133	3	DCLK2	4	151141909	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	2068242	151141909	40012367	49	22428										
MARCH11	441061	broad.mit.edu	37	chr5	16067594	16067594	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cttttgtcacactgaagtcaCtctcatcacaacctcccccg	4	17	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:16067594C>T	uc003jfo.2	-	4	1408	c.1195G>A	c.(1195-1197)GTG>ATG	p.V399M	MARCH11_uc010itw.1_Missense_Mutation_p.V155M	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	399	PDZ-binding.					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						ACTGAAGTCACTCTCATCACA	0.443													0	0	0	0.323286	0	136	155										T	16067594	C	T	16067594	3	4	73	1	0	0	0	0	1	0	0	0	9300	565	20	2	17	2	MARCH11	5	16067594	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		16067594	164847666	50	22429										
BDP1	55814	broad.mit.edu	37	chr5	70806316	70806316	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccccaagggagaagacaccaGaggtgattgatgccactgag	13	10	0	6			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:70806316G>A	uc003kbp.1	+	17	3660	c.3397G>A	c.(3397-3399)GAG>AAG	p.E1133K	BDP1_uc003kbn.1_Missense_Mutation_p.E1133K|BDP1_uc003kbo.2_Missense_Mutation_p.E1133K	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1133	6.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GAAGACACCAGAGGTGATTGA	0.478													0	0	0	0.234183	0	19	59										A	70806316	G	A	70806316	3	1	73	1	0	0	0	0	1	0	0	0	1395	943	33	1	3463	1	BDP1	5	70806316	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	54738722	70806316	110108944	51	22430										
HSD17B4	3295	broad.mit.edu	37	chr5	118814608	118814608	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtgctgcaaagttgggtcttCtgggccttgcaaattctctt	11	9	3	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:118814608C>G	uc003ksj.2	+	8	637	c.514C>G	c.(514-516)CTG>GTG	p.L172V	HSD17B4_uc011cwg.1_Missense_Mutation_p.L148V|HSD17B4_uc011cwh.1_Missense_Mutation_p.L154V|HSD17B4_uc011cwi.1_Missense_Mutation_p.L197V|HSD17B4_uc003ksk.3_Missense_Mutation_p.L25V|HSD17B4_uc011cwj.1_Missense_Mutation_p.L25V|HSD17B4_uc010jcn.1_5'UTR	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	172	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GTTGGGTCTTCTGGGCCTTGC	0.408													0	0	0	0.246493	0	38	71										G	118814608	C	G	118814608	3	3	73	1	0	0	0	0	1	0	0	0	7386	912	32	1	544	1	HSD17B4	5	118814608	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	48008292	118814608	62100652	52	22431										
PRRC1	133619	broad.mit.edu	37	chr5	126883526	126883529	+	Frame_Shift_Del	DEL	TTGT	TTGT	-													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgcagatggtttgacattggTtgtttggtggttgaagatcc							TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:126883526_126883529delTTGT	uc003kuk.2	+	8	1221_1224	c.1041_1044delTTGT	c.(1039-1044)GGTTGTfs	p.G347fs	PRRC1_uc003kuj.3_Frame_Shift_Del_p.G347fs	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	347_348						Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		TTGACATTGGTTGTTTGGTGGTTG	0.358																		36	62	---	---								-	126883529	TTGT	-	126883526	7	5	73	1	0	1	0	1	0	0	0	0	12604	1712	60	0	1067	0	PRRC1	5	126883526	Frame_Shift_Del	DEL	TTGT	TCGA-FD-A3B5-01A-11D-A20D-08	8068918	126883526	54031734	53	22432										
PCDHA7	56141	broad.mit.edu	37	chr5	140214295	140214295	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agcatccacctggaggtgatCgtggaaaggccgctgcaggt	15	10	0	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:140214295C>T	uc003lhq.2	+	1	327	c.327C>T	c.(325-327)ATC>ATT	p.I109I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.I109I	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	109	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGGTGATCGTGGAAAGGC	0.552													0	0	0	0.163468	0	29	214										T	140214295	C	T	140214295	2	4	73	1	0	0	0	0	0	0	0	1	11529	874	31	1		1	PCDHA7	5	140214295	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	13330769	140214295	40700965	54	22433										
DOCK2	1794	broad.mit.edu	37	chr5	169494533	169494533	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gaccacaattagtcctctggAgaatgccatagaaaccatgt	8	10	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:169494533A>T	uc003maf.2	+	45	4567	c.4487A>T	c.(4486-4488)GAG>GTG	p.E1496V	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E988V|DOCK2_uc003mah.2_Missense_Mutation_p.E52V	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1496	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTCCTCTGGAGAATGCCATA	0.418													0	0	0	0.219247	0	20	41										T	169494533	A	T	169494533	3	4	73	1	0	0	0	0	1	0	0	0	4687	304	11	5	4665	5	DOCK2	5	169494533	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	29280238	169494533	11420727	55	22434										
COL11A2	1302	broad.mit.edu	37	chr6	33144976	33144976	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	accttctctccatgagggccGatggcaccctggggcccggg	14	15	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:33144976G>A	uc003ocx.1	-	24	2226	c.1998C>T	c.(1996-1998)ATC>ATT	p.I666I	COL11A2_uc010jul.1_Missense_Mutation_p.S46L|COL11A2_uc003ocy.1_Silent_p.I580I|COL11A2_uc003ocz.1_Silent_p.I559I	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	666	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CATGAGGGCCGATGGCACCCT	0.547													0	0	0	0.193644	0	30	33										A	33144976	G	A	33144976	2	1	73	1	0	0	0	0	0	0	0	1	3668	1048	37	1		1	COL11A2	6	33144976	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		33144976	137970091	56	22435										
UHRF1BP1	54887	broad.mit.edu	37	chr6	34825934	34825934	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tggaaaagagagagcgggcaGagttgcatcgtccccaggcc	15	10	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:34825934G>C	uc003oju.3	+	14	2035	c.1801G>C	c.(1801-1803)GAG>CAG	p.E601Q	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	601										ovary(3)	3						AGAGCGGGCAGAGTTGCATCG	0.473													0	0	0	0.214465	0	35	46										C	34825934	G	C	34825934	3	2	73	1	0	0	0	0	1	0	0	0	16965	943	33	1	1855	1	UHRF1BP1	6	34825934	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	1680958	34825934	136289133	57	22436			1	101		3	3	582	G		5.250712e-06
UHRF1BP1	54887	broad.mit.edu	37	chr6	34826146	34826146	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tttttgcatcatgcctttcaGatggattcctgcctgcctca	7	12	3	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:34826146G>A	uc003oju.3	+	14	2247	c.2013G>A	c.(2011-2013)CAG>CAA	p.Q671Q	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	671										ovary(3)	3						ATGCCTTTCAGATGGATTCCT	0.488													0	0	0	0.323286	0	41	70										A	34826146	G	A	34826146	2	1	73	1	0	0	0	0	0	0	0	1	16965	933	33	1		1	UHRF1BP1	6	34826146	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	212	34826146	136288921	58	22437			1	101		3	3	582	G		5.250712e-06
UHRF1BP1	54887	broad.mit.edu	37	chr6	34826515	34826515	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acagaagtcatggaaattctGaaagaaggcagtagtggtat	12	4	2	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:34826515G>A	uc003oju.3	+	14	2616	c.2382G>A	c.(2380-2382)CTG>CTA	p.L794L	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	794										ovary(3)	3						TGGAAATTCTGAAAGAAGGCA	0.493													0	0	0	0.323286	0	77	79										A	34826515	G	A	34826515	2	1	73	1	0	0	0	0	0	0	0	1	16965	1277	45	1		1	UHRF1BP1	6	34826515	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	369	34826515	136288552	59	22438			1	101		3	3	582	G		5.250712e-06
TRERF1	55809	broad.mit.edu	37	chr6	42204105	42204106	+	In_Frame_Ins	INS	-	-	TCC													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atttcctatcttcttccgggINStcctcctcctcctcctcctc					rs146190272	by1000genomes	TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:42204105_42204106insTCC	uc003osd.2	-	16	3466_3467	c.2903_2904insGGA	c.(2902-2904)GAC>GAGGAC	p.967_968insE	TRERF1_uc011duq.1_In_Frame_Ins_p.884_885insE|TRERF1_uc003osb.2_In_Frame_Ins_p.723_724insE|TRERF1_uc003osc.2_In_Frame_Ins_p.723_724insE|TRERF1_uc003ose.2_In_Frame_Ins_p.987_988insE	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	967_968	Interacts with CREBBP.|Glu-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTTCCGGGtcctcctcctc	0.465																		3	5	---	---								TCC	42204106	-	TCC	42204105	7	5	73	1	0	1	1	0	0	0	0	0	16472	1252	44	0	710	0	TRERF1	6	42204105	In_Frame_Ins	INS	-	TCGA-FD-A3B5-01A-11D-A20D-08	7377590	42204105	128910962	60	22439										
MDN1	23195	broad.mit.edu	37	chr6	90398348	90398348	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	caagtgactgacagcctctgAgaaaccttgaagcacaggtt	10	10	1	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:90398348A>G	uc003pnn.1	-	66	11319	c.11203T>C	c.(11203-11205)TCA>CCA	p.S3735P		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3735					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACAGCCTCTGAGAAACCTTGA	0.537													0	0	0	0.307466	0	8	16										G	90398348	A	G	90398348	3	3	73	1	0	0	0	0	1	0	0	0	9415	304	11	5	5735	5	MDN1	6	90398348	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	48194243	90398348	80716719	61	22440										
PTPRK	5796	broad.mit.edu	37	chr6	128540172	128540173	+	Frame_Shift_Del	DEL	AG	AG	-													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgtcacttcttgcaatctgaAggaagcggcaaaccttctat							TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:128540172_128540173delAG	uc003qbk.2	-	6	1129_1130	c.762_763delCT	c.(760-765)TCCTTCfs	p.S254fs	PTPRK_uc003qbj.2_Frame_Shift_Del_p.S254fs|PTPRK_uc010kfc.2_Frame_Shift_Del_p.S254fs|PTPRK_uc011ebu.1_Frame_Shift_Del_p.S254fs|PTPRK_uc003qbl.1_Frame_Shift_Del_p.S124fs|PTPRK_uc011ebv.1_Frame_Shift_Del_p.S254fs	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	254_255	Extracellular (Potential).|Ig-like C2-type.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TGCAATCTGAAGGAAGCGGCAA	0.411																		15	107	---	---								-	128540173	AG	-	128540172	7	5	73	1	0	1	0	1	0	0	0	0	12805	72	3	0	3681	0	PTPRK	6	128540172	Frame_Shift_Del	DEL	AG	TCGA-FD-A3B5-01A-11D-A20D-08	38141824	128540172	42574895	62	22441										
TULP4	56995	broad.mit.edu	37	chr6	158923390	158923390	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acagcagtggcaacgtggagGaggtgtgccggccccgcacc	16	13	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:158923390G>A	uc003qrf.2	+	13	4052	c.2695G>A	c.(2695-2697)GAG>AAG	p.E899K	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	899					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CAACGTGGAGGAGGTGTGCCG	0.642													0	0	0	0.323286	0	47	72										A	158923390	G	A	158923390	3	1	73	1	0	0	0	0	1	0	0	0	16773	1175	41	1	2745	1	TULP4	6	158923390	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	30383218	158923390	12191677	63	22442										
ADAP1	11033	broad.mit.edu	37	chr7	938746	938746	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cactccctctggtcggactcCgtctcgcaggcaaacagaaa	9	15	2	1	rs146090079		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:938746C>T	uc003sjo.3	-	10	1196	c.1020G>A	c.(1018-1020)ACG>ACA	p.T340T	ADAP1_uc003sjm.3_Silent_p.T166T|ADAP1_uc011jvs.1_Silent_p.T245T|ADAP1_uc003sjn.3_Silent_p.T268T|ADAP1_uc010ksc.2_Silent_p.T268T	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	340	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			upper_aerodigestive_tract(1)	1						GGTCGGACTCCGTCTCGCAGG	0.597													0	0	0	0.268233	0	39	63										T	938746	C	T	938746	2	4	73	1	0	0	0	0	0	0	0	1	279	639	23	2		2	ADAP1	7	938746	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		938746	158199917	64	22443										
DAGLB	221955	broad.mit.edu	37	chr7	6449968	6449968	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgggcaagttgttggggtttCctccaaacagttcgtaccac	11	10	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:6449968C>G	uc003sqa.2	-	14	1783	c.1613G>C	c.(1612-1614)GGA>GCA	p.G538A	DAGLB_uc003spy.2_Missense_Mutation_p.G84A|DAGLB_uc003spz.2_Missense_Mutation_p.G235A|DAGLB_uc011jwt.1_Missense_Mutation_p.G352A|DAGLB_uc011jwu.1_Missense_Mutation_p.G409A|DAGLB_uc003sqb.2_Missense_Mutation_p.G257A|DAGLB_uc003sqc.2_Missense_Mutation_p.G257A|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.G497A	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	538	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GTTGGGGTTTCCTCCAAACAG	0.592													0	0	0	0.257332	0	36	56										G	6449968	C	G	6449968	3	3	73	1	0	0	0	0	1	0	0	0	4227	855	30	1	413	1	DAGLB	7	6449968	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	5511222	6449968	152688695	65	22444										
DNAH11	8701	broad.mit.edu	37	chr7	21932046	21932046	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttcctttgtggttcaagactGaagatgaactgatgctggca	11	7	1	5			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:21932046G>A	uc003svc.2	+	78	12563	c.12532G>A	c.(12532-12534)GAA>AAA	p.E4178K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4178					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTTCAAGACTGAAGATGAACT	0.478									Kartagener_syndrome				0	0	0	0.323286	0	124	215										A	21932046	G	A	21932046	3	1	73	1	0	0	0	0	1	0	0	0	4599	1291	45	1	12839	1	DNAH11	7	21932046	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	15482078	21932046	137206617	66	22445										
UBE2D4	51619	broad.mit.edu	37	chr7	43982600	43982600	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttcttcctgaccatccacttTcctacagattacccgttcaa	3	15	2	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:43982600T>C	uc003tja.1	+	4	253	c.168T>C	c.(166-168)TTT>TTC	p.F56F	POLR2J4_uc003tjc.2_RNA|UBE2D4_uc003tjb.1_Silent_p.F18F	NM_015983	NP_057067	Q9Y2X8	UB2D4_HUMAN	ubiquitin-conjugating enzyme E2D 4 (putative)	56					protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity				0						CCATCCACTTTCCTACAGATT	0.507													0	0	0	0.323286	0	64	90										C	43982600	T	C	43982600	2	2	73	1	0	0	0	0	0	0	0	1	16848	1780	62	5		5	UBE2D4	7	43982600	Silent	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08	22050554	43982600	115156063	67	22446										
NPC1L1	29881	broad.mit.edu	37	chr7	44573141	44573141	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcaaaggtccgcacagctggCatgggggtcagggcccctgt	16	12	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:44573141C>T	uc003tlb.2	-	8	2354	c.2298G>A	c.(2296-2298)ATG>ATA	p.M766I	NPC1L1_uc003tlc.2_Missense_Mutation_p.M766I|NPC1L1_uc011kbw.1_Missense_Mutation_p.M766I|NPC1L1_uc003tld.2_3'UTR	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	766	Extracellular (Potential).|SSD.				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCACAGCTGGCATGGGGGTCA	0.632													0	0	0	0.27861	0	8	90										T	44573141	C	T	44573141	3	4	73	1	0	0	0	0	1	0	0	0	10571	710	25	2	1833	2	NPC1L1	7	44573141	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	590541	44573141	114565522	68	22447										
PKD1L1	168507	broad.mit.edu	37	chr7	47884664	47884664	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cttaggagagcgaatgccgcGaggcgatggtagctaggagg	18	7	0	1	rs140257069		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:47884664G>A	uc003tny.1	-	33	5166	c.5166C>T	c.(5164-5166)CTC>CTT	p.L1722L		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1722	Extracellular (Potential).|GPS.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CGAATGCCGCGAGGCGATGGT	0.463													0	0	0	0.183431	0	27	31										A	47884664	G	A	47884664	2	1	73	1	0	0	0	0	0	0	0	1	11964	1045	37	1		1	PKD1L1	7	47884664	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	3311523	47884664	111253999	69	22448										
PSPH	5723	broad.mit.edu	37	chr7	56079478	56079478	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttcttccagttctcccagcaGctctacaaaatcagtgatat	5	12	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:56079478G>T	uc003trg.2	-	7	1018	c.655C>A	c.(655-657)CTG>ATG	p.L219M	PSPH_uc003trh.2_Missense_Mutation_p.L219M|PSPH_uc003tri.2_Missense_Mutation_p.L219M|PSPH_uc003trj.2_Missense_Mutation_p.L248M	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	219					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCTCCCAGCAGCTCTACAAAA	0.378													1	0	3.28513e-13	0.294199	3.63093e-13	22	122										T	56079478	G	T	56079478	3	4	73	1	0	0	0	0	1	0	0	0	12717	962	34	4	26	4	PSPH	7	56079478	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	8194814	56079478	103059185	70	22449										
RABGEF1	27342	broad.mit.edu	37	chr7	66273984	66273984	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctcccaggaagcaagaagctGagagttggtctcctgatgct	12	10	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:66273984G>A	uc011kee.1	+	9	1395	c.1231G>A	c.(1231-1233)GAG>AAG	p.E411K	RABGEF1_uc003tvf.2_Missense_Mutation_p.E270K|RABGEF1_uc003tvg.2_Missense_Mutation_p.E205K|RABGEF1_uc010lag.2_Missense_Mutation_p.E397K|RABGEF1_uc003tvh.2_Missense_Mutation_p.E397K|RABGEF1_uc003tvi.2_Missense_Mutation_p.E231K	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	614					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						GCAAGAAGCTGAGAGTTGGTC	0.453													0	0	0	0.294199	0	25	15										A	66273984	G	A	66273984	3	1	73	1	0	0	0	0	1	0	0	0	12966	1291	45	1	1219	1	RABGEF1	7	66273984	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	10194506	66273984	92864679	71	22450										
RABGEF1	27342	broad.mit.edu	37	chr7	66274059	66274059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atctcttgtctcagttgaatGaacgacaagaaaggatcatg	9	7	3	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:66274059G>C	uc011kee.1	+	9	1470	c.1306G>C	c.(1306-1308)GAA>CAA	p.E436Q	RABGEF1_uc003tvf.2_Missense_Mutation_p.E295Q|RABGEF1_uc003tvg.2_Missense_Mutation_p.E230Q|RABGEF1_uc010lag.2_Missense_Mutation_p.E422Q|RABGEF1_uc003tvh.2_Missense_Mutation_p.E422Q|RABGEF1_uc003tvi.2_Missense_Mutation_p.E256Q	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	639	Potential.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TCAGTTGAATGAACGACAAGA	0.428													0	0	0	0.175082	0	18	32										C	66274059	G	C	66274059	3	2	73	1	0	0	0	0	1	0	0	0	12966	1291	45	1	1294	1	RABGEF1	7	66274059	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	75	66274059	92864604	72	22451										
ZNF655	79027	broad.mit.edu	37	chr7	99170613	99170613	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tcaggcataattcagcataaGaaaattcacaccagagccaa	6	10	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:99170613G>C	uc003urh.2	+	3	1275	c.882G>C	c.(880-882)AAG>AAC	p.K294N	ZNF655_uc010lga.2_Missense_Mutation_p.K329N|ZNF655_uc010lgc.2_Missense_Mutation_p.K329N|ZNF655_uc003urj.2_Missense_Mutation_p.K294N|ZNF655_uc003urk.2_Missense_Mutation_p.K131N|ZNF655_uc010lgd.2_Missense_Mutation_p.K131N	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	294					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					TTCAGCATAAGAAAATTCACA	0.383													0	0	0	0.125774	0	30	66										C	99170613	G	C	99170613	3	2	73	1	0	0	0	0	1	0	0	0	18065	933	33	1	1419	1	ZNF655	7	99170613	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	32896554	99170613	59968050	73	22452										
STAG3	10734	broad.mit.edu	37	chr7	99798542	99798542	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	actttgcccgcagccagctaGtagatttgctgactgaccgc	10	13	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:99798542G>T	uc003utx.1	+	19	2166	c.2011G>T	c.(2011-2013)GTA>TTA	p.V671L	STAG3_uc010lgs.1_Missense_Mutation_p.V459L|STAG3_uc011kjk.1_Missense_Mutation_p.V613L|GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc003uua.3_3'UTR|GATS_uc010lgt.2_RNA|STAG3_uc003uub.1_5'UTR	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	671					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAGCCAGCTAGTAGATTTGCT	0.592													1	0	2.31682e-05	0.132662	2.37333e-05	10	67										T	99798542	G	T	99798542	3	4	73	1	0	0	0	0	1	0	0	0	15243	1029	36	4	2081	4	STAG3	7	99798542	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	627929	99798542	59340121	74	22453										
MUC17	140453	broad.mit.edu	37	chr7	100683101	100683101	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctgaagttaccagcatgccaAcctcaactcctagtgaaaca	6	13	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:100683101A>G	uc003uxp.1	+	3	8457	c.8404A>G	c.(8404-8406)ACC>GCC	p.T2802A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2802	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCATGCCAACCTCAACTCC	0.493													0	0	0	0.323286	0	109	388										G	100683101	A	G	100683101	3	3	73	1	0	0	0	0	1	0	0	0	9974	43	2	5	8414	5	MUC17	7	100683101	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	884559	100683101	58455562	75	22454										
EPHB6	2051	broad.mit.edu	37	chr7	142567654	142567654	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccagtgatgtctggagctttGggatactcatgtgggaagtg	15	6	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:142567654G>C	uc011kst.1	+	17	3329	c.2542G>C	c.(2542-2544)GGG>CGG	p.G848R	EPHB6_uc011ksu.1_Missense_Mutation_p.G848R|EPHB6_uc003wbs.2_Missense_Mutation_p.G556R|EPHB6_uc003wbt.2_Missense_Mutation_p.G322R|EPHB6_uc003wbu.2_Missense_Mutation_p.G556R|EPHB6_uc003wbv.2_Missense_Mutation_p.G232R	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	848	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CTGGAGCTTTGGGATACTCAT	0.522													0	0	0	0.134883	0	24	28										C	142567654	G	C	142567654	3	2	73	1	0	0	0	0	1	0	0	0	5178	1348	47	4	2592	4	EPHB6	7	142567654	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	41884553	142567654	16571009	76	22455										
MLL3	58508	broad.mit.edu	37	chr7	151879673	151879673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttgctgcttacttttctgacGcatttgctattaaaatagaa	6	7	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:151879673G>A	uc003wla.2	-	36	5491	c.5272C>T	c.(5272-5274)CGT>TGT	p.R1758C	MLL3_uc003wkz.2_Missense_Mutation_p.R819C	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1758	Potential.|Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTTTCTGACGCATTTGCTAT	0.294			N		medulloblastoma								0	0	0	0.144211	0	28	59										A	151879673	G	A	151879673	3	1	73	1	0	0	0	0	1	0	0	0	9622	1087	38	2	9559	2	MLL3	7	151879673	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	9312019	151879673	7258990	77	22456										
CSMD1	64478	broad.mit.edu	37	chr8	3265577	3265577	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aatgccatcatccttgaccgCgagaaagtcaaactgaggct	9	11	2	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:3265577C>T	uc011kwk.1	-	14	2308	c.1918G>A	c.(1918-1920)GCG>ACG	p.A640T	CSMD1_uc011kwj.1_Missense_Mutation_p.A32T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	640	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCTTGACCGCGAGAAAGTCA	0.453													0	0	0	0.307466	0	6	32										T	3265577	C	T	3265577	3	4	73	1	0	0	0	0	1	0	0	0	3944	768	27	2	9007	2	CSMD1	8	3265577	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		3265577	143098445	78	22457										
CHMP7	91782	broad.mit.edu	37	chr8	23112846	23112846	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctgtcagagctcagcaccctCtgtgctaactcctgcccaga	8	16	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:23112846C>T	uc003xdc.2	+	4	1206	c.558C>T	c.(556-558)CTC>CTT	p.L186L	CHMP7_uc011kzs.1_RNA|CHMP7_uc003xdd.2_Silent_p.L76L|CHMP7_uc003xde.2_Silent_p.L44L	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	186					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TCAGCACCCTCTGTGCTAACT	0.582													0	0	0	0.125774	0	28	41										T	23112846	C	T	23112846	2	4	73	1	0	0	0	0	0	0	0	1	3361	900	32	1		1	CHMP7	8	23112846	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	19847269	23112846	123251176	79	22458										
PPP2R2A	5520	broad.mit.edu	37	chr8	26227900	26227900	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccgtagctactacaaacaatCtgtatatatttcaagacaaa	4	9	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:26227900C>T	uc003xeu.2	+	10	1617	c.1315C>T	c.(1315-1317)CTG>TTG	p.L439L	PPP2R2A_uc003xek.2_Silent_p.L440L|PPP2R2A_uc011laf.1_Silent_p.L449L	NM_002717	NP_002708	P63151	2ABA_HUMAN	alpha isoform of regulatory subunit B55, protein	439	WD 7.				protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TACAAACAATCTGTATATATT	0.393													0	0	0	0.193644	0	29	50										T	26227900	C	T	26227900	2	4	73	1	0	0	0	0	0	0	0	1	12384	912	32	1		1	PPP2R2A	8	26227900	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	3115054	26227900	120136122	80	22459										
PREX2	80243	broad.mit.edu	37	chr8	69030877	69030877	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccacagtgatgaaatggactCaggtgtgttcgttggtgaag	14	6	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:69030877C>G	uc003xxv.1	+	27	3446	c.3419C>G	c.(3418-3420)TCA>TGA	p.S1140*		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1140					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GAAATGGACTCAGGTGTGTTC	0.418													0	0	0	0.323286	0	44	49										G	69030877	C	G	69030877	4	3	73	1	0	0	0	0	0	1	0	0	12477	838	29	1	3754	1	PREX2	8	69030877	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	42802977	69030877	77333145	81	22460										
UBR5	51366	broad.mit.edu	37	chr8	103373850	103373850	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cagcttctcagaaacttctcGtaacctttaaaacaaaacat	3	11	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:103373850G>C	uc003ykr.1	-	2	100	c.67C>G	c.(67-69)CGA>GGA	p.R23G	UBR5_uc003yks.1_Missense_Mutation_p.R23G	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	23					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GAAACTTCTCGTAACCTTTAA	0.264													0	0	0	0.217242	0	5	62										C	103373850	G	C	103373850	3	2	73	1	0	0	0	0	1	0	0	0	16902	1153	40	4	8564	4	UBR5	8	103373850	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	34342973	103373850	42990172	82	22461										
EXOSC4	54512	broad.mit.edu	37	chr8	145134859	145134859	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cttccagatccggggctcccGggctcgagccctgccggaca	13	17	0	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:145134859G>T	uc003zau.2	+	2	295	c.185G>T	c.(184-186)CGG>CTG	p.R62L	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	62					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGGGCTCCCGGGCTCGAGCC	0.612													1	0	4.67007e-22	0.268233	5.27265e-22	34	123										T	145134859	G	T	145134859	3	4	73	1	0	0	0	0	1	0	0	0	5317	1116	39	4	191	4	EXOSC4	8	145134859	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	41761009	145134859	1229163	83	22462										
NAA35	60560	broad.mit.edu	37	chr9	88611429	88611429	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atggtgaactattttgcaagAttaatagatagaataaaaac	7	3	0	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:88611429A>T	uc004aoi.3	+	12	1130	c.993A>T	c.(991-993)AGA>AGT	p.R331S	NAA35_uc004aoj.3_Missense_Mutation_p.R331S	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	331					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						ATTTTGCAAGATTAATAGATA	0.353													0	0	0	0.246493	0	40	19										T	88611429	A	T	88611429	3	4	73	1	0	0	0	0	1	0	0	0	10123	330	12	5	1035	5	NAA35	9	88611429	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08		88611429	52602002	84	22463										
GAPVD1	26130	broad.mit.edu	37	chr9	128113141	128113141	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aactgctggcttcgattgctGaggactacaggtaatatacc	10	9	0	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:128113141G>C	uc010mwx.2	+	23	3939	c.3613G>C	c.(3613-3615)GAG>CAG	p.E1205Q	GAPVD1_uc004bpp.2_Missense_Mutation_p.E1214Q|GAPVD1_uc004bpq.2_Missense_Mutation_p.E1187Q|GAPVD1_uc004bpr.2_Missense_Mutation_p.E1166Q|GAPVD1_uc004bps.2_Missense_Mutation_p.E1160Q|GAPVD1_uc004bpt.2_Missense_Mutation_p.E220Q	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1205					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TTCGATTGCTGAGGACTACAG	0.383													0	0	0	0.184627	0	4	82										C	128113141	G	C	128113141	3	2	73	1	0	0	0	0	1	0	0	0	6239	1291	45	1	3722	1	GAPVD1	9	128113141	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	39501712	128113141	13100290	85	22464										
SLC2A6	11182	broad.mit.edu	37	chr9	136341379	136341379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	caagggcgtagagggacaggGatccgaacactgccatgagc	15	10	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:136341379G>A	uc004cee.2	-	4	637	c.542C>T	c.(541-543)TCC>TTC	p.S181F	SLC2A6_uc004cef.2_Missense_Mutation_p.S181F|SLC2A6_uc004ceg.2_Missense_Mutation_p.S181F|SLC2A6_uc011mdj.1_Missense_Mutation_p.S181F	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	181	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		GAGGGACAGGGATCCGAACAC	0.647													0	0	0	0.150653	0	4	44										A	136341379	G	A	136341379	3	1	73	1	0	0	0	0	1	0	0	0	14549	1174	41	1	1009	1	SLC2A6	9	136341379	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	8228238	136341379	4872052	86	22465										
RXRA	6256	broad.mit.edu	37	chr9	137293588	137293588	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcatcggctccccgggacagCtgcattctcccatcagcacc	9	18	2	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:137293588C>G	uc004cfb.2	+	2	301	c.139C>G	c.(139-141)CTG>GTG	p.L47V	RXRA_uc004cfa.1_Missense_Mutation_p.A97G	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	47	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCCGGGACAGCTGCATTCTCC	0.697													0	0	0	0.323286	0	56	28										G	137293588	C	G	137293588	3	3	73	1	0	0	0	0	1	0	0	0	13763	796	28	4	145	4	RXRA	9	137293588	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	952209	137293588	3919843	87	22466										
CELF2	10659	broad.mit.edu	37	chr10	11308619	11308619	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cagaatgcaatcaaagccatGcatcagtctcagaccatgga	8	11	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:11308619G>A	uc001iki.3	+	6	668	c.576G>A	c.(574-576)ATG>ATA	p.M192I	CELF2_uc010qbi.1_Intron|CELF2_uc010qbj.1_Missense_Mutation_p.M192I|CELF2_uc001ikk.2_Missense_Mutation_p.M199I|CELF2_uc001ikl.3_Missense_Mutation_p.M199I|CELF2_uc010qbk.1_Intron|CELF2_uc010qbl.1_Missense_Mutation_p.M168I|CELF2_uc010qbm.1_Intron|CELF2_uc001iko.3_Missense_Mutation_p.M168I|CELF2_uc001ikp.3_Missense_Mutation_p.M168I|CELF2_uc010qbn.1_Missense_Mutation_p.M176I|CELF2_uc010qbo.1_Missense_Mutation_p.M81I|CELF2_uc010qbp.1_Intron	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	192	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						TCAAAGCCATGCATCAGTCTC	0.453													0	0	0	0.217242	0	5	34										A	11308619	G	A	11308619	3	1	73	1	0	0	0	0	1	0	0	0	3216	1319	46	2	676	2	CELF2	10	11308619	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		11308619	124226128	88	22467										
A1CF	29974	broad.mit.edu	37	chr10	52569778	52569778	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcttcatccacaaaggcactCagctttggaggtgtgaaagg	12	9	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:52569778C>T	uc001jjj.2	-	12	1697	c.1509G>A	c.(1507-1509)CTG>CTA	p.L503L	A1CF_uc010qhn.1_Silent_p.L503L|A1CF_uc001jji.2_Silent_p.L495L|A1CF_uc001jjh.2_Silent_p.L503L|A1CF_uc010qho.1_Silent_p.L511L|A1CF_uc009xov.2_Silent_p.L495L	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	503					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CAAAGGCACTCAGCTTTGGAG	0.483													0	0	0	0.279207	0	20	43										T	52569778	C	T	52569778	2	4	73	1	0	0	0	0	0	0	0	1	2	813	29	1		1	A1CF	10	52569778	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	41261159	52569778	82964969	89	22468										
NRG3	10718	broad.mit.edu	37	chr10	84118578	84118578	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	catactgtctcaatgatggcGagtgctttgtgatcgaaacc	10	9	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:84118578G>C	uc001kco.2	+	2	934	c.907G>C	c.(907-909)GAG>CAG	p.E303Q	NRG3_uc010qlz.1_Missense_Mutation_p.E303Q|NRG3_uc001kcp.2_Missense_Mutation_p.E82Q|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	303	EGF-like.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CAATGATGGCGAGTGCTTTGT	0.547													0	0	0	0.279207	0	24	59										C	84118578	G	C	84118578	3	2	73	1	0	0	0	0	1	0	0	0	10649	1059	37	1	1081	1	NRG3	10	84118578	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	31548800	84118578	51416169	90	22469										
KIF11	3832	broad.mit.edu	37	chr10	94368903	94368903	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atgaagagctttttgatcttCttaatccatcatctgatgtt	6	7	4	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:94368903C>G	uc001kic.2	+	5	822	c.514C>G	c.(514-516)CTT>GTT	p.L172V	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	172	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						TTTTGATCTTCTTAATCCATC	0.333													0	0	0	0.234183	0	19	82										G	94368903	C	G	94368903	3	3	73	1	0	0	0	0	1	0	0	0	8272	913	32	1	532	1	KIF11	10	94368903	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	10250325	94368903	41165844	91	22470										
CHUK	1147	broad.mit.edu	37	chr10	101967090	101967090	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atatagctatcacagcctctCtgaaaaagaaacaaacagtt	5	9	2	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:101967090C>T	uc001kqp.2	-	11	1184	c.1129_splice	c.e11-1	p.R377_splice		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity	p.?(1)		ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CACAGCCTCTCTGAAAAAGAA	0.308													0	0	0	0.184627	0	4	35										T	101967090	C	T	101967090	5	4	73	1	0	0	0	0	0	0	1	0	3416	927	32	1	1153	1	CHUK	10	101967090	Splice_Site	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	7598187	101967090	33567657	92	22471										
DCLRE1A	9937	broad.mit.edu	37	chr10	115596920	115596920	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aggtcgaaatgccaaaatctGattgtatttcccaccacact	6	11	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:115596920G>A	uc001law.2	-	8	3781	c.2863C>T	c.(2863-2865)CAG>TAG	p.Q955*		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	955					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GCCAAAATCTGATTGTATTTC	0.368								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.268233	0	37	74										A	115596920	G	A	115596920	4	1	73	1	0	0	0	0	0	1	0	0	4294	1299	45	1	267	1	DCLRE1A	10	115596920	Nonsense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	13629830	115596920	19937827	93	22472										
FGFR2	2263	broad.mit.edu	37	chr10	123274680	123274680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tggtcagcttgtgcacagccGgctggctgctgaagtctggc	15	11	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:123274680G>A	uc010qtk.1	-	9	1885	c.1238C>T	c.(1237-1239)CCG>CTG	p.P413L	FGFR2_uc010qtg.1_Missense_Mutation_p.P301L|FGFR2_uc010qth.1_Missense_Mutation_p.P298L|FGFR2_uc010qti.1_Missense_Mutation_p.P324L|FGFR2_uc010qtj.1_Missense_Mutation_p.P414L|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Missense_Mutation_p.P298L|FGFR2_uc001lfl.3_Missense_Mutation_p.P414L|FGFR2_uc001lfm.2_Missense_Mutation_p.P325L|FGFR2_uc001lfn.3_RNA|FGFR2_uc001lfg.3_Missense_Mutation_p.P23L	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	413	Cytoplasmic (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTGCACAGCCGGCTGGCTGCT	0.493		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.249174	0	19	77										A	123274680	G	A	123274680	3	1	73	1	0	0	0	0	1	0	0	0	5866	1116	39	2	1371	2	FGFR2	10	123274680	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	7677760	123274680	12260067	94	22473										
CDHR5	53841	broad.mit.edu	37	chr11	620354	620354	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cggtctccgtcctcagcgtaGatgggtccgggacgcaggac	15	13	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:620354G>C	uc001lqj.2	-	8	927	c.822C>G	c.(820-822)ATC>ATG	p.I274M	CDHR5_uc001lqk.2_Missense_Mutation_p.I274M|CDHR5_uc009ycc.2_Missense_Mutation_p.I108M|CDHR5_uc009ycd.2_Missense_Mutation_p.I274M|CDHR5_uc001lql.2_Missense_Mutation_p.I274M|CDHR5_uc001lqm.2_Missense_Mutation_p.I108M|CDHR5_uc009yce.1_Missense_Mutation_p.I243M	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	274	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CCTCAGCGTAGATGGGTCCGG	0.657													0	0	0	0.069234	0	9	57										C	620354	G	C	620354	3	2	73	1	0	0	0	0	1	0	0	0	3122	932	33	1	1747	1	CDHR5	11	620354	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		620354	134386162	95	22474										
LRDD	55367	broad.mit.edu	37	chr11	802398	802401	+	Splice_Site	DEL	TGAG	TGAG	-													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttgaggggtcacaggaaagcTgagtgaggaaggagcgagca							TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:802398_802401delTGAG	uc001lro.1	-	6	1117	c.975_splice	c.e6-1	p.S325_splice	LRDD_uc009yck.1_Splice_Site|LRDD_uc001lrk.1_Splice_Site_p.S325_splice|LRDD_uc001lrl.1_Splice_Site_p.S179_splice|LRDD_uc001lrm.1_Splice_Site_p.S12_splice|LRDD_uc001lrn.1_Splice_Site_p.S179_splice|LRDD_uc001lrp.1_Splice_Site	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing						apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGGAAAGCTGAGTGAGGAAGGA	0.632																		14	46	---	---								-	802401	TGAG	-	802398	8	5	73	1	0	1	0	1	0	0	1	0	8936	1594	55	0	1803	0	LRDD	11	802398	Splice_Site	DEL	TGAG	TCGA-FD-A3B5-01A-11D-A20D-08	182044	802398	134204118	96	22475										
DUSP8	1850	broad.mit.edu	37	chr11	1579452	1579452	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgaagtcaggcttggggcagGagttgctggcgttgaggacg	19	6	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:1579452G>C	uc001lts.2	-	5	715	c.587C>G	c.(586-588)TCC>TGC	p.S196C		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	196	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		CTTGGGGCAGGAGTTGCTGGC	0.592													0	0	0	0.160694	0	18	20										C	1579452	G	C	1579452	3	2	73	1	0	0	0	0	1	0	0	0	4831	1174	41	1	1302	1	DUSP8	11	1579452	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	777054	1579452	133427064	97	22476										
OR52K1	390036	broad.mit.edu	37	chr11	4510933	4510933	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtcatgcaccgtgtagcccGccatgctgcccctcgtgtcc	10	17	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:4510933G>A	uc001lza.1	+	1	803	c.803G>A	c.(802-804)CGC>CAC	p.R268H		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CGTGTAGCCCGCCATGCTGCC	0.502													0	0	0	0.193644	0	30	167										A	4510933	G	A	4510933	3	1	73	1	0	0	0	0	1	0	0	0	11123	1087	38	2	805	2	OR52K1	11	4510933	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	2931481	4510933	130495583	98	22477										
NLRP10	338322	broad.mit.edu	37	chr11	7981220	7981220	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtattttttggtgtttcctCtgtccctctgccttttccag	7	11	2	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:7981220C>G	uc001mfv.1	-	2	1956	c.1939G>C	c.(1939-1941)GAG>CAG	p.E647Q		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	647							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGTGTTTCCTCTGTCCCTCTG	0.259													0	0	0	0.105934	0	11	12										G	7981220	C	G	7981220	3	3	73	1	0	0	0	0	1	0	0	0	10472	922	32	1	32	1	NLRP10	11	7981220	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	3470287	7981220	127025296	99	22478										
NLRP10	338322	broad.mit.edu	37	chr11	7981650	7981650	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atctcatcattcccttcctgCtcctttacctccagcagcct	3	18	2	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:7981650C>G	uc001mfv.1	-	2	1526	c.1509G>C	c.(1507-1509)GAG>GAC	p.E503D		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	503							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCCTTCCTGCTCCTTTACCT	0.488													0	0	0	0.214465	0	34	25										G	7981650	C	G	7981650	3	3	73	1	0	0	0	0	1	0	0	0	10472	796	28	4	462	4	NLRP10	11	7981650	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	430	7981650	127024866	100	22479										
TMEM132A	54972	broad.mit.edu	37	chr11	60695125	60695125	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccctccaggtggtcccccctCgagtcactgagccccaccaa	8	20	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:60695125C>T	uc001nqj.2	+	3	521	c.328C>T	c.(328-330)CGA>TGA	p.R110*	TMEM132A_uc001nqi.2_Nonsense_Mutation_p.R110*|TMEM132A_uc001nqk.2_Nonsense_Mutation_p.R123*|TMEM132A_uc001nql.1_Nonsense_Mutation_p.R123*	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	110	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						GGTCCCCCCTCGAGTCACTGA	0.597													0	0	0	0.175082	0	12	169										T	60695125	C	T	60695125	4	4	73	1	0	0	0	0	0	1	0	0	16042	876	31	1	338	1	TMEM132A	11	60695125	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	52713475	60695125	74311391	101	22480										
INTS5	80789	broad.mit.edu	37	chr11	62416037	62416037	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ggccgggtatagacagacagCaggcccaagagctggtgctg	16	10	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:62416037C>T	uc001nud.2	-	2	1568	c.1515G>A	c.(1513-1515)CTG>CTA	p.L505L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	505					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AGACAGACAGCAGGCCCAAGA	0.562													0	0	0	0.204396	0	17	100										T	62416037	C	T	62416037	2	4	73	1	0	0	0	0	0	0	0	1	7781	697	25	2		2	INTS5	11	62416037	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	1720912	62416037	72590479	102	22481										
MRPL21	219927	broad.mit.edu	37	chr11	68660897	68660897	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtggcttgccaagcagcgtGaagttgtctgccccaaccag	12	12	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:68660897G>T	uc001ooi.2	-	5	448	c.423C>A	c.(421-423)TTC>TTA	p.F141L	MRPL21_uc001ooh.2_Missense_Mutation_p.F56L|MRPL21_uc010rqe.1_Missense_Mutation_p.F141L	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	141					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAAGCAGCGTGAAGTTGTCTG	0.507													1	0	2.43139e-17	0.323286	2.70155e-17	49	50										T	68660897	G	T	68660897	3	4	73	1	0	0	0	0	1	0	0	0	9787	1281	45	3	206	3	MRPL21	11	68660897	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	6244860	68660897	66345619	103	22482										
P2RY2	5029	broad.mit.edu	37	chr11	72945902	72945902	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aaagccagcctacgggacctCgggcggcctgcctagggcca	14	15	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:72945902C>T	uc001otj.2	+	3	1031	c.698C>T	c.(697-699)TCG>TTG	p.S233L	P2RY2_uc001otk.2_Missense_Mutation_p.S233L|P2RY2_uc001otl.2_Missense_Mutation_p.S233L	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	233	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	TACGGGACCTCGGGCGGCCTG	0.647													0	0	0	0.323286	0	61	56										T	72945902	C	T	72945902	3	4	73	1	0	0	0	0	1	0	0	0	11352	893	31	1	700	1	P2RY2	11	72945902	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	4285005	72945902	62060614	104	22483										
B3GNT6	192134	broad.mit.edu	37	chr11	76751660	76751660	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atgtaccgcgagttgctgctAgtgcaccgcttcgcgcccta	11	14	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:76751660A>G	uc001oxw.2	+	6	1150	c.1062A>G	c.(1060-1062)CTA>CTG	p.L354L		NM_138706	NP_619651	Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal	354	Lumenal (Potential).				O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity				0						AGTTGCTGCTAGTGCACCGCT	0.682													0	0	0	0.27861	0	6	26										G	76751660	A	G	76751660	2	3	73	1	0	0	0	0	0	0	0	1	1261	407	15	5		5	B3GNT6	11	76751660	Silent	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	3805758	76751660	58254856	105	22484										
ATM	472	broad.mit.edu	37	chr11	108196036	108196036	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	actctatgtcgtggcattcaGatcagtcacacatagacaac	7	11	4	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:108196036G>A	uc001pkb.1	+	46	6958	c.6573_splice	c.e46-1	p.R2191_splice	ATM_uc009yxr.1_Splice_Site_p.R2191_splice|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Splice_Site_p.R843_splice|ATM_uc001pkg.1_Splice_Site_p.R548_splice	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGGCATTCAGATCAGTCACA	0.328			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.323286	0	48	14										A	108196036	G	A	108196036	5	1	73	1	0	0	0	0	0	0	1	0	1109	956	33	1	6750	1	ATM	11	108196036	Splice_Site	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	31444376	108196036	26810480	106	22485										
C11orf65	160140	broad.mit.edu	37	chr11	108264059	108264059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgcagtgtgaattagtcctaGagtttcatgatgtgttgact	11	5	1	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:108264059G>C	uc001pkh.2	-	7	677	c.607C>G	c.(607-609)CTA>GTA	p.L203V	C11orf65_uc010rvx.1_Missense_Mutation_p.L154V|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	203										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ATTAGTCCTAGAGTTTCATGA	0.413													0	0	0	0.080935	0	10	89										C	108264059	G	C	108264059	3	2	73	1	0	0	0	0	1	0	0	0	1655	933	33	1	346	1	C11orf65	11	108264059	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	68023	108264059	26742457	107	22486										
VPS11	55823	broad.mit.edu	37	chr11	118949563	118949563	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtaccggcaggtcatcagcGtgtgtgagcgccatggggag	17	9	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:118949563G>A	uc010ryx.1	+	14	2164	c.2122G>A	c.(2122-2124)GTG>ATG	p.V708M	VPS11_uc010ryy.1_Missense_Mutation_p.V554M	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	708					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GGTCATCAGCGTGTGTGAGCG	0.622													0	0	0	0.132662	0	15	9										A	118949563	G	A	118949563	3	1	73	1	0	0	0	0	1	0	0	0	17185	1145	40	2	2171	2	VPS11	11	118949563	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	10685504	118949563	16056953	108	22487										
VSIG2	23584	broad.mit.edu	37	chr11	124620668	124620668	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tagaaatctggtgggttgttGacttggcagaggtaggttcc	15	5	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:124620668G>T	uc001qas.2	-	3	445	c.369C>A	c.(367-369)GTC>GTA	p.V123V	VSIG2_uc001qat.2_Silent_p.V123V	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	123	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GTGGGTTGTTGACTTGGCAGA	0.552													1	0	6.49762e-13	0.175082	7.14398e-13	16	20										T	124620668	G	T	124620668	2	4	73	1	0	0	0	0	0	0	0	1	17221	1277	45	3		3	VSIG2	11	124620668	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	5671105	124620668	10385848	109	22488										
KDM5A	5927	broad.mit.edu	37	chr12	427453	427453	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgataaggtcagtcttacttCgtccaaccaccgagcctgtt	8	12	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:427453C>A	uc001qif.1	-	19	3079	c.2716G>T	c.(2716-2718)GAA>TAA	p.E906*	KDM5A_uc001qie.1_Nonsense_Mutation_p.E906*|KDM5A_uc010sdn.1_Nonsense_Mutation_p.E865*	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	906					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AGTCTTACTTCGTCCAACCAC	0.488			T 	NUP98	AML								1	0	2.32078e-09	0.132662	2.49931e-09	13	140										A	427453	C	A	427453	4	1	73	1	0	0	0	0	0	1	0	0	8133	893	31	3	2396	3	KDM5A	12	427453	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		427453	133424442	110	22489										
FOXM1	2305	broad.mit.edu	37	chr12	2973567	2973567	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gccaggggcaatggcaccttCaccgagggctgcaacaccag	13	14	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:2973567C>T	uc001qlf.2	-	8	1450	c.1185G>A	c.(1183-1185)GTG>GTA	p.V395V	FOXM1_uc001qle.2_Silent_p.V395V|FOXM1_uc001qlg.2_Silent_p.V380V|FOXM1_uc009zea.2_Silent_p.V380V|FOXM1_uc009zeb.2_Silent_p.V379V	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	395					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			ATGGCACCTTCACCGAGGGCT	0.592													0	0	0	0.323286	0	50	90										T	2973567	C	T	2973567	2	4	73	1	0	0	0	0	0	0	0	1	6018	813	29	1		1	FOXM1	12	2973567	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	2546114	2973567	130878328	111	22490										
KIF21A	55605	broad.mit.edu	37	chr12	39761747	39761747	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ataaattcctccagttgaatCttcatgaattcttatatttg	4	7	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:39761747C>A	uc001rly.2	-	4	684	c.538G>T	c.(538-540)GAT>TAT	p.D180Y	KIF21A_uc001rlx.2_Missense_Mutation_p.D180Y|KIF21A_uc001rlz.2_Missense_Mutation_p.D180Y|KIF21A_uc010skl.1_Missense_Mutation_p.D180Y|KIF21A_uc001rma.1_Missense_Mutation_p.D180Y	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	180	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCAGTTGAATCTTCATGAATT	0.308													1	0	1.39843e-22	0.323286	1.58741e-22	50	147										A	39761747	C	A	39761747	3	1	73	1	0	0	0	0	1	0	0	0	8288	913	32	3	4626	3	KIF21A	12	39761747	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	36788180	39761747	94090148	112	22491										
MLL2	8085	broad.mit.edu	37	chr12	49415856	49415858	+	In_Frame_Del	DEL	GAT	GAT	-													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttggggattcgccggctggaGatgatgatgattttgtcctc							TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			GAT	-	GAT	GAT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:49415856_49415858delGAT	uc001rta.3	-	53	16489_16491	c.16489_16491delATC	c.(16489-16491)ATCdel	p.I5497del		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5497	Poly-Ile.|SET.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCGGCTGGAGATGATGATGATT	0.527			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								177	79	---	---								-	49415858	GAT	-	49415856	7	5	73	1	0	1	0	1	0	0	0	0	9621	932	33	0	130	0	MLL2	12	49415856	In_Frame_Del	DEL	GAT	TCGA-FD-A3B5-01A-11D-A20D-08	9654109	49415856	84436039	113	22492										
ZC3H10	84872	broad.mit.edu	37	chr12	56515546	56515546	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtggcccctgtggctgtatcGatggcccaacccttggcagg	14	13	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:56515546G>A	uc001sjp.1	+	3	1389	c.1200G>A	c.(1198-1200)TCG>TCA	p.S400S		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	400							nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			TGGCTGTATCGATGGCCCAAC	0.592													0	0	0	0.307466	0	8	70										A	56515546	G	A	56515546	2	1	73	1	0	0	0	0	0	0	0	1	17556	1045	37	1		1	ZC3H10	12	56515546	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	7099690	56515546	77336349	114	22493										
NAP1L1	4673	broad.mit.edu	37	chr12	76449866	76449866	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aaaaacagttaaccaaaattCaggaattcctttggggtctt	7	7	2	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:76449866C>T	uc001sxw.2	-	7	917	c.505G>A	c.(505-507)GAA>AAA	p.E169K	NAP1L1_uc001sxv.2_Missense_Mutation_p.E127K|NAP1L1_uc001sxz.2_Missense_Mutation_p.E100K|NAP1L1_uc001sxx.2_Missense_Mutation_p.E169K|NAP1L1_uc001sxy.2_Missense_Mutation_p.E106K|NAP1L1_uc010sty.1_Missense_Mutation_p.E126K|NAP1L1_uc010stz.1_5'UTR|NAP1L1_uc010sua.1_Missense_Mutation_p.E169K|NAP1L1_uc001syb.2_Missense_Mutation_p.E169K|NAP1L1_uc001sya.2_Missense_Mutation_p.E127K|NAP1L1_uc001syc.2_Missense_Mutation_p.E180K	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	169					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				AACCAAAATTCAGGAATTCCT	0.328													0	0	0	0.080935	0	12	36										T	76449866	C	T	76449866	3	4	73	1	0	0	0	0	1	0	0	0	10156	835	29	1	706	1	NAP1L1	12	76449866	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	19934320	76449866	57402029	115	22494										
ACSS3	79611	broad.mit.edu	37	chr12	81647291	81647291	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tagatataaatgcaacagagGagcaagttttggaagaaatt	10	3	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:81647291G>C	uc001szl.1	+	15	1928	c.1837G>C	c.(1837-1839)GAG>CAG	p.E613Q	ACSS3_uc001szm.1_Missense_Mutation_p.E612Q|ACSS3_uc001szn.1_Missense_Mutation_p.E295Q	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	613						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TGCAACAGAGGAGCAAGTTTT	0.398													0	0	0	0.323286	0	62	17										C	81647291	G	C	81647291	3	2	73	1	0	0	0	0	1	0	0	0	190	1175	41	1	1895	1	ACSS3	12	81647291	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	5197425	81647291	52204604	116	22495										
ATP2B1	490	broad.mit.edu	37	chr12	90028786	90028786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttacttaccatatttcacttGagcaatatctccaacagtaa	3	10	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:90028786G>C	uc001tbh.2	-	3	830	c.649C>G	c.(649-651)CAA>GAA	p.Q217E	ATP2B1_uc001tbg.2_Missense_Mutation_p.Q217E	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	217	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TATTTCACTTGAGCAATATCT	0.348													0	0	0	0.323286	0	61	27										C	90028786	G	C	90028786	3	2	73	1	0	0	0	0	1	0	0	0	1139	1299	45	1	3243	1	ATP2B1	12	90028786	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	8381495	90028786	43823109	117	22496										
CLIP1	6249	broad.mit.edu	37	chr12	122758620	122758620	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aggtcatccccgttcccattCagggctgcttctgacatcat	8	14	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:122758620C>G	uc001ucg.1	-	24	4162	c.4056G>C	c.(4054-4056)CTG>CTC	p.L1352L	CLIP1_uc001uch.1_Silent_p.L1341L|CLIP1_uc001uci.1_Silent_p.L1306L|CLIP1_uc001ucf.1_Silent_p.L11L	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1352	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CGTTCCCATTCAGGGCTGCTT	0.313													0	0	0	0.323286	0	119	139										G	122758620	C	G	122758620	2	3	73	1	0	0	0	0	0	0	0	1	3532	813	29	1		1	CLIP1	12	122758620	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	32729834	122758620	11093275	118	22497										
ANKLE2	23141	broad.mit.edu	37	chr12	133313491	133313491	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cagctcaccttggctggactCaggggccctgcgaaggctct	13	14	3	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:133313491C>T	uc001ukx.2	-	8	1648	c.1581G>A	c.(1579-1581)CTG>CTA	p.L527L	ANKLE2_uc009zyw.1_5'Flank|ANKLE2_uc001uky.3_Silent_p.L465L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	527						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TGGCTGGACTCAGGGGCCCTG	0.627													0	0	0	0.301197	0	40	61										T	133313491	C	T	133313491	2	4	73	1	0	0	0	0	0	0	0	1	633	813	29	1		1	ANKLE2	12	133313491	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	10554871	133313491	538404	119	22498										
PCDH8	5100	broad.mit.edu	37	chr13	53420246	53420246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcgcacctccttcttgcggcGgttgcaggtggtggcgatgg	17	11	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr13:53420246G>A	uc001vhi.2	-	1	2529	c.2326C>T	c.(2326-2328)CGC>TGC	p.R776C	PCDH8_uc001vhj.2_Missense_Mutation_p.R776C	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	776	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTCTTGCGGCGGTTGCAGGTG	0.617													0	0	0	0.27861	0	6	44										A	53420246	G	A	53420246	3	1	73	1	0	0	0	0	1	0	0	0	11517	1116	39	2	898	2	PCDH8	13	53420246	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		53420246	61749632	120	22499										
RBM26	64062	broad.mit.edu	37	chr13	79945269	79945269	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ataatctcttttgcgagaacGatcatcttttttcctctcat	4	10	4	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr13:79945269G>A	uc001vkz.2	-	5	459	c.445C>T	c.(445-447)CGT>TGT	p.R149C	RBM26_uc001vky.2_Missense_Mutation_p.R149C|RBM26_uc001vla.2_Missense_Mutation_p.R149C|RBM26_uc001vkx.2_5'Flank|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	149	Arg-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTGCGAGAACGATCATCTTTT	0.383													0	0	0	0.125774	0	27	23										A	79945269	G	A	79945269	3	1	73	1	0	0	0	0	1	0	0	0	13126	1058	37	1	2565	1	RBM26	13	79945269	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	26525023	79945269	35224609	121	22500										
C14orf106	55320	broad.mit.edu	37	chr14	45673353	45673353	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aaaataataatctttctcttCttcatctaaagattccacag	2	9	5	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:45673353C>T	uc001wwf.2	-	17	3817	c.3358G>A	c.(3358-3360)GAA>AAA	p.E1120K		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	1120					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TCTTTCTCTTCTTCATCTAAA	0.289													0	0	0	0.204396	0	20	28										T	45673353	C	T	45673353	3	4	73	1	0	0	0	0	1	0	0	0	1738	922	32	1	44	1	C14orf106	14	45673353	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		45673353	61676187	122	22501										
SOCS4	122809	broad.mit.edu	37	chr14	55509991	55509991	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gttcatccattgagttggacTtagatcattcctgtgggcat	10	8	2	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:55509991T>C	uc001xbo.2	+	3	797	c.232T>C	c.(232-234)TTA>CTA	p.L78L	SOCS4_uc001xbp.2_Silent_p.L78L	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	78					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						TGAGTTGGACTTAGATCATTC	0.423													0	0	0	0.323286	0	55	74										C	55509991	T	C	55509991	2	2	73	1	0	0	0	0	0	0	0	1	14916	1606	56	5		5	SOCS4	14	55509991	Silent	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08	9836638	55509991	51839549	123	22502										
SYNE2	23224	broad.mit.edu	37	chr14	64457725	64457725	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtttcaccagatttggacatCaggctgaagatggaagaatc	11	7	2	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:64457725C>G	uc001xgm.2	+	21	2768	c.2538C>G	c.(2536-2538)ATC>ATG	p.I846M	SYNE2_uc001xgl.2_Missense_Mutation_p.I846M	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	846	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATTTGGACATCAGGCTGAAGA	0.423													0	0	0	0.248553	0	6	70										G	64457725	C	G	64457725	3	3	73	1	0	0	0	0	1	0	0	0	15443	816	29	1	2616	1	SYNE2	14	64457725	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	8947734	64457725	42891815	124	22503										
SLC8A3	6547	broad.mit.edu	37	chr14	70518710	70518710	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctcactgtttgcctgaccttGaactcataggactcttcaat	6	12	4	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:70518710G>C	uc001xly.2	-	5	2782	c.2028C>G	c.(2026-2028)TTC>TTG	p.F676L	SLC8A3_uc001xlu.2_Missense_Mutation_p.F33L|SLC8A3_uc001xlv.2_Missense_Mutation_p.F47L|SLC8A3_uc001xlw.2_Missense_Mutation_p.F673L|SLC8A3_uc001xlx.2_Missense_Mutation_p.F674L|SLC8A3_uc001xlz.2_Missense_Mutation_p.F670L|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Missense_Mutation_p.F33L	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	676	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCCTGACCTTGAACTCATAGG	0.308													0	0	0	0.09319	0	12	23										C	70518710	G	C	70518710	3	2	73	1	0	0	0	0	1	0	0	0	14708	1281	45	1	771	1	SLC8A3	14	70518710	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	6060985	70518710	36830830	125	22504										
LTBP2	4053	broad.mit.edu	37	chr14	75052569	75052569	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ggacttacccagctggtggcGactgtggtgcgggcggcgac	18	11	0	0	rs143282840		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:75052569G>A	uc001xqa.2	-	3	1205	c.818C>T	c.(817-819)TCG>TTG	p.S273L		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	273					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGCTGGTGGCGACTGTGGTGC	0.647													0	0	0	0.105934	0	11	29										A	75052569	G	A	75052569	3	1	73	1	0	0	0	0	1	0	0	0	9074	1059	37	1	4783	1	LTBP2	14	75052569	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	4533859	75052569	32296971	126	22505										
IFI27	3429	broad.mit.edu	37	chr14	94582170	94582170	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtgccatgggcttcactgcGgcgggaatcgcctcgtcctc	13	14	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:94582170G>A	uc010tws.1	+	4	353	c.232G>A	c.(232-234)GGC>AGC	p.G78S	IFI27_uc001ycn.1_RNA|IFI27_uc001yco.2_Silent_p.A58A	NM_005532	NP_005523	P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27 isoform	Error:Variant_position_missing_in_P40305_after_alignment					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion					0				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		GCTTCACTGCGGCGGGAATCG	0.642													0	0	0	0.217242	0	6	8										A	94582170	G	A	94582170	3	1	73	1	0	0	0	0	1	0	0	0	7512	1103	39	2	175	2	IFI27	14	94582170	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	19529601	94582170	12767370	127	22506										
KIAA0284	283638	broad.mit.edu	37	chr14	105349634	105349634	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gatgactgcagccctggcaaGatgaagatcaaggaccatat	11	9	1	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:105349634G>C	uc010axb.2	+	8	1064	c.840G>C	c.(838-840)AAG>AAC	p.K280N	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.K210N|KIAA0284_uc001yps.2_Missense_Mutation_p.K186N	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	280						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GCCCTGGCAAGATGAAGATCA	0.637													0	0	0	0.058154	0	10	23										C	105349634	G	C	105349634	3	2	73	1	0	0	0	0	1	0	0	0	8166	933	33	1	866	1	KIAA0284	14	105349634	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	10767464	105349634	1999906	128	22507										
RPAP1	26015	broad.mit.edu	37	chr15	41819472	41819472	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctccagcacgtagcgcagccGaggcagcaggctggtagcca	14	14	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:41819472G>A	uc001zod.2	-	13	1763	c.1639C>T	c.(1639-1641)CGG>TGG	p.R547W		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	547						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TAGCGCAGCCGAGGCAGCAGG	0.622													0	0	0	0.234183	0	20	32										A	41819472	G	A	41819472	3	1	73	1	0	0	0	0	1	0	0	0	13541	1057	37	1	2594	1	RPAP1	15	41819472	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		41819472	60711920	129	22508										
CAPN3	825	broad.mit.edu	37	chr15	42702003	42702003	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aggacatggagatctgtgcaGatgagctcaagaaggtcctt	13	7	2	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:42702003G>A	uc001zpn.1	+	18	2317	c.2011G>A	c.(2011-2013)GAT>AAT	p.D671N	CAPN3_uc001zpk.1_Missense_Mutation_p.D438N|CAPN3_uc001zpl.1_Missense_Mutation_p.D578N|CAPN3_uc010udf.1_Missense_Mutation_p.D584N|CAPN3_uc010udg.1_Missense_Mutation_p.D536N|CAPN3_uc001zpo.1_Missense_Mutation_p.D665N|CAPN3_uc001zpp.1_Missense_Mutation_p.D579N|CAPN3_uc001zpq.1_Missense_Mutation_p.D159N|CAPN3_uc010bcv.1_Missense_Mutation_p.D6N|CAPN3_uc001zpr.1_Missense_Mutation_p.D6N|CAPN3_uc001zps.1_Missense_Mutation_p.D6N|CAPN3_uc001zpt.1_Missense_Mutation_p.D6N	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	671	EF-hand 1.|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GATCTGTGCAGATGAGCTCAA	0.537													0	0	0	0.323286	0	118	129										A	42702003	G	A	42702003	3	1	73	1	0	0	0	0	1	0	0	0	2628	942	33	1	2133	1	CAPN3	15	42702003	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	882531	42702003	59829389	130	22509										
TGM5	9333	broad.mit.edu	37	chr15	43552710	43552710	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acaagcaggtggtccacagtGatctcctccgtgtggtgccg	13	12	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:43552710G>A	uc001zrd.1	-	2	86	c.78C>T	c.(76-78)ATC>ATT	p.I26I	TGM5_uc001zre.1_Silent_p.I26I	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	26					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GGTCCACAGTGATCTCCTCCG	0.577													0	0	0	0.323286	0	68	69										A	43552710	G	A	43552710	2	1	73	1	0	0	0	0	0	0	0	1	15830	1280	45	1		1	TGM5	15	43552710	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	850707	43552710	58978682	131	22510										
FBXO22	26263	broad.mit.edu	37	chr15	76206519	76206519	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tccccaaacaatgccaagtcCttgggattgtgaccccagga	9	13	0	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:76206519C>G	uc002bbk.2	+	4	541	c.436C>G	c.(436-438)CTT>GTT	p.L146V	FBXO22_uc002bbj.1_Missense_Mutation_p.L146V|FBXO22_uc002bbl.2_Missense_Mutation_p.L42V	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	146					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						ATGCCAAGTCCTTGGGATTGT	0.383													0	0	0	0.249174	0	18	43										G	76206519	C	G	76206519	3	3	73	1	0	0	0	0	1	0	0	0	5734	681	24	4	450	4	FBXO22	15	76206519	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	32653809	76206519	26324873	132	22511										
PKD1	5310	broad.mit.edu	37	chr16	2142498	2142498	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	caccttcctgcagccgcaccTgccgcagccgtgggggcccc	12	20	0	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:2142498T>A	uc002cos.1	-	39	11461	c.11252A>T	c.(11251-11253)CAG>CTG	p.Q3751L	PKD1_uc002cot.1_Missense_Mutation_p.Q3750L|MIR1225_hsa-mir-1225|MI0006311_5'Flank|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3751	Polycystin motif.|Extracellular (Potential).		Q -> R (in ADPKD1).|Missing (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CAGCCGCACCTGCCGCAGCCG	0.592													0	0	0	0.080935	0	6	13										A	2142498	T	A	2142498	3	1	73	1	0	0	0	0	1	0	0	0	11963	1580	55	5	1691	5	PKD1	16	2142498	Missense_Mutation	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08		2142498	88212255	133	22512										
C16orf71	146562	broad.mit.edu	37	chr16	4790239	4790239	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgcatcctctcaggaaggaaGagaccctggcaggccttttg	12	11	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:4790239G>A	uc002cxn.2	+	4	824	c.362G>A	c.(361-363)AGA>AAA	p.R121K		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	121										central_nervous_system(1)	1						CAGGAAGGAAGAGACCCTGGC	0.572													0	0	0	0.279185	0	38	55										A	4790239	G	A	4790239	3	1	73	1	0	0	0	0	1	0	0	0	1830	942	33	1	372	1	C16orf71	16	4790239	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	2647741	4790239	85564514	134	22513										
CACNG3	10368	broad.mit.edu	37	chr16	24372924	24372924	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcctcccaccctacaggtatCgattccggaggcggtcaagt	11	14	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:24372924C>T	uc002dmf.2	+	4	1888	c.688C>T	c.(688-690)CGA>TGA	p.R230*		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	230					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CTACAGGTATCGATTCCGGAG	0.537													0	0	0	0.175082	0	15	41										T	24372924	C	T	24372924	4	4	73	1	0	0	0	0	0	1	0	0	2558	876	31	1	702	1	CACNG3	16	24372924	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	19582685	24372924	65981829	135	22514										
RABEP2	79874	broad.mit.edu	37	chr16	28935803	28935803	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acagcctcggccttcgtgctCtcgctcacctctgccacagc	8	19	3	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:28935803C>G	uc002drq.2	-	2	243	c.195G>C	c.(193-195)GAG>GAC	p.E65D	uc010vct.1_Intron|RABEP2_uc010vdf.1_Intron|RABEP2_uc010byn.2_Missense_Mutation_p.E65D|RABEP2_uc002drr.2_Missense_Mutation_p.E65D	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	65	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CCTTCGTGCTCTCGCTCACCT	0.647													0	0	0	0.217242	0	4	88										G	28935803	C	G	28935803	3	3	73	1	0	0	0	0	1	0	0	0	12962	912	32	1	1562	1	RABEP2	16	28935803	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	4562879	28935803	61418950	136	22515										
IRX5	10265	broad.mit.edu	37	chr16	54965196	54965196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtacagcaccagcgtcatttCggggccccgcacggatgagc	13	14	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:54965196C>T	uc002ehv.2	+	1	86	c.86C>T	c.(85-87)TCG>TTG	p.S29L	uc010vhb.1_5'Flank|uc010vhc.1_5'Flank|uc002ehu.1_5'Flank|IRX5_uc010cca.1_Missense_Mutation_p.S29L|IRX5_uc002ehw.2_5'Flank	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	29					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						AGCGTCATTTCGGGGCCCCGC	0.682													0	0	0	0.248553	0	6	11										T	54965196	C	T	54965196	3	4	73	1	0	0	0	0	1	0	0	0	7847	893	31	1	88	1	IRX5	16	54965196	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	26029393	54965196	35389557	137	22516										
GNAO1	2775	broad.mit.edu	37	chr16	56368731	56368731	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agggtcaaaaccactggcatCgtagaaacccacttcacatt	7	12	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:56368731C>G	uc002eit.3	+	5	1452	c.555C>G	c.(553-555)ATC>ATG	p.I185M	GNAO1_uc002eiu.3_Missense_Mutation_p.I185M	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	185					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				CCACTGGCATCGTAGAAACCC	0.612													0	0	0	0.160694	0	16	27										G	56368731	C	G	56368731	3	3	73	1	0	0	0	0	1	0	0	0	6508	874	31	1	573	1	GNAO1	16	56368731	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	1403535	56368731	33986022	138	22517										
CDH8	1006	broad.mit.edu	37	chr16	61858917	61858917	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtgcaggaaattaacttactCtgtgcaaattttggaggatt	10	5	1	0	rs148693252	byFrequency	TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:61858917C>T	uc002eog.1	-	5	1086	c.834G>A	c.(832-834)CAG>CAA	p.Q278Q	CDH8_uc002eoh.2_Silent_p.Q47Q	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	278	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTAACTTACTCTGTGCAAATT	0.353													0	0	0	0.189662	0	15	23										T	61858917	C	T	61858917	2	4	73	1	0	0	0	0	0	0	0	1	3116	927	32	1		1	CDH8	16	61858917	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	5490186	61858917	28495836	139	22518										
ATP2C2	9914	broad.mit.edu	37	chr16	84495721	84495721	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gagggtcttccagacggagaAcctgggagcgcttggtgagt	17	8	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:84495721A>G	uc002fhx.2	+	26	2797	c.2708A>G	c.(2707-2709)AAC>AGC	p.N903S	ATP2C2_uc010chj.2_Missense_Mutation_p.N932S|ATP2C2_uc002fhy.2_Missense_Mutation_p.N920S|ATP2C2_uc002fhz.2_Missense_Mutation_p.N752S|ATP2C2_uc002fia.2_Missense_Mutation_p.N214S	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	903	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CAGACGGAGAACCTGGGAGCG	0.657													0	0	0	0.069234	0	10	81										G	84495721	A	G	84495721	3	3	73	1	0	0	0	0	1	0	0	0	1144	43	2	5	2810	5	ATP2C2	16	84495721	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	22636804	84495721	5859032	140	22519										
ZNF287	57336	broad.mit.edu	37	chr17	16466508	16466508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tatcaccatccatggttcttCcaatatgggaatcacagttg	7	10	3	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:16466508C>T	uc002gqi.2	-	5	1120	c.667G>A	c.(667-669)GAA>AAA	p.E223K		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	216	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CATGGTTCTTCCAATATGGGA	0.358													0	0	0	0.214465	0	30	15										T	16466508	C	T	16466508	3	4	73	1	0	0	0	0	1	0	0	0	17822	864	30	1	1626	1	ZNF287	17	16466508	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		16466508	64728702	141	22520										
C17orf37	84299	broad.mit.edu	37	chr17	37886006	37886006	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctgtccatttatctctatctCaaaggcacctggtaagaaat	6	10	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:37886006C>T	uc002hsq.2	-	3	236	c.196G>A	c.(196-198)GAG>AAG	p.E66K		NM_032339	NP_115715	Q9BRT3	CQ037_HUMAN	hypothetical protein LOC84299	66					cell redox homeostasis	cytosol|membrane	selenium binding				0	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;3.72e-63)|all cancers(3;1.87e-56)|BRCA - Breast invasive adenocarcinoma(8;6.8e-45)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATCTCTATCTCAAAGGCACCT	0.488													0	0	0	0.323286	0	49	88										T	37886006	C	T	37886006	3	4	73	1	0	0	0	0	1	0	0	0	1854	835	29	1	159	1	C17orf37	17	37886006	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	21419498	37886006	43309204	142	22521										
TUBG2	27175	broad.mit.edu	37	chr17	40815491	40815491	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tacaattcactcctgacactCaagaggctgacgcagaacgc	8	13	2	4			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:40815491C>G	uc010wgr.1	+	6	832	c.576C>G	c.(574-576)CTC>CTG	p.L192L	TUBG2_uc002iaq.2_Silent_p.L34L|TUBG2_uc002iar.2_Silent_p.L39L|TUBG2_uc002ias.2_Silent_p.L34L|TUBG2_uc002iap.2_Silent_p.L39L	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	192					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TCCTGACACTCAAGAGGCTGA	0.383													0	0	0	0.323286	0	86	111										G	40815491	C	G	40815491	2	3	73	1	0	0	0	0	0	0	0	1	16762	813	29	1		1	TUBG2	17	40815491	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	2929485	40815491	40379719	143	22522										
TEX14	56155	broad.mit.edu	37	chr17	56651579	56651579	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tttcagttcctttggtgactCctttgatgtctcttcttgtt	7	9	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:56651579C>A	uc010dcz.1	-	23	3608	c.3490G>T	c.(3490-3492)GAG>TAG	p.E1164*	TEX14_uc002iwr.1_Nonsense_Mutation_p.E1158*|TEX14_uc002iws.1_Nonsense_Mutation_p.E1118*|TEX14_uc010dda.1_Nonsense_Mutation_p.E898*	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1164						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTGGTGACTCCTTTGATGTC	0.368													1	0	1.13719e-10	0.134883	1.23736e-10	25	62										A	56651579	C	A	56651579	4	1	73	1	0	0	0	0	0	1	0	0	15775	864	30	3	1047	3	TEX14	17	56651579	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	15836088	56651579	24543631	144	22523										
KCNH6	81033	broad.mit.edu	37	chr17	61611651	61611651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	atccctttcgacctcctgatCttccgcactggctccgatga	7	16	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:61611651C>G	uc002jay.2	+	5	1160	c.1080C>G	c.(1078-1080)ATC>ATG	p.I360M	KCNH6_uc002jax.1_Missense_Mutation_p.I360M|KCNH6_uc010wpl.1_Missense_Mutation_p.I237M|KCNH6_uc010wpm.1_Missense_Mutation_p.I360M|KCNH6_uc002jaz.1_Missense_Mutation_p.I360M	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	360	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	ACCTCCTGATCTTCCGCACTG	0.632													0	0	0	0.294199	0	22	63										G	61611651	C	G	61611651	3	3	73	1	0	0	0	0	1	0	0	0	8036	903	32	1	1098	1	KCNH6	17	61611651	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	4960072	61611651	19583559	145	22524										
SFRS2	6427	broad.mit.edu	37	chr17	74732295	74732295	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acttggggggactcttcgatCgcgacctggatttggattcc	13	10	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:74732295C>A	uc002jsv.2	-	2	784	c.614G>T	c.(613-615)CGA>CTA	p.R205L	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R205L|SFRS2_uc010wtg.1_Missense_Mutation_p.R193L|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	205	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						ACTCTTCGATCGCGACCTGGA	0.542													1	0	9.78306e-22	0.144211	1.09863e-21	29	85										A	74732295	C	A	74732295	3	1	73	1	0	0	0	0	1	0	0	0	14175	884	31	3	55	3	SFRS2	17	74732295	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	13120644	74732295	6462915	146	22525										
SLC26A11	284129	broad.mit.edu	37	chr17	78225191	78225191	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tccagtacttctctaccctgGaagaagcaggtgggcacagt	11	11	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:78225191G>T	uc002jyb.1	+	17	1989	c.1720G>T	c.(1720-1722)GAA>TAA	p.E574*	SLC26A11_uc002jyc.1_Nonsense_Mutation_p.E574*|SLC26A11_uc002jyd.1_Nonsense_Mutation_p.E574*|SLC26A11_uc010dhv.1_Nonsense_Mutation_p.E574*	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	574	Extracellular (Potential).|STAS.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTCTACCCTGGAAGAAGCAGG	0.458													1	0	1.12875e-08	0.116897	1.20938e-08	25	83										T	78225191	G	T	78225191	4	4	73	1	0	0	0	0	0	1	0	0	14516	1175	41	3	1778	3	SLC26A11	17	78225191	Nonsense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	3492896	78225191	2970019	147	22526										
EMILIN2	84034	broad.mit.edu	37	chr18	2891297	2891297	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agcccggctacaggagccttCagcccaggcaaattgctgcg	12	14	1	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr18:2891297C>T	uc002kln.2	+	4	1331	c.1172C>T	c.(1171-1173)TCA>TTA	p.S391L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	391					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CAGGAGCCTTCAGCCCAGGCA	0.488													0	0	0	0.294199	0	27	34										T	2891297	C	T	2891297	3	4	73	1	0	0	0	0	1	0	0	0	5094	838	29	1	1186	1	EMILIN2	18	2891297	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		2891297	75185951	148	22527										
C18orf25	147339	broad.mit.edu	37	chr18	43796552	43796552	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gcagcaagacaatcactgcaGagataccaggtagaggatgt	12	8	1	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr18:43796552G>T	uc002lbw.2	+	2	1085	c.706G>T	c.(706-708)GAG>TAG	p.E236*	C18orf25_uc002lbx.2_Nonsense_Mutation_p.E236*	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	236										central_nervous_system(2)	2						AATCACTGCAGAGATACCAGG	0.433													1	0	0.000442599	0.058154	0.000449014	9	17										T	43796552	G	T	43796552	4	4	73	1	0	0	0	0	0	1	0	0	1899	943	33	3	708	3	C18orf25	18	43796552	Nonsense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	40905255	43796552	34280696	149	22528										
DENND1C	79958	broad.mit.edu	37	chr19	6476930	6476930	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	caggagcgccgcgaacagccCcacgatgttctcgtcagtca	11	15	3	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:6476930C>T	uc002mfe.2	-	10	708	c.616G>A	c.(616-618)GGG>AGG	p.G206R	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.G162R	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	206	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						GCGAACAGCCCCACGATGTTC	0.672													0	0	0	0.27861	0	7	35										T	6476930	C	T	6476930	3	4	73	1	0	0	0	0	1	0	0	0	4428	623	22	2	1845	2	DENND1C	19	6476930	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		6476930	52652053	150	22529										
IL27RA	9466	broad.mit.edu	37	chr19	14159887	14159887	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tccgtctgggggttcagggaGgaattaggtaagagtggggc	19	5	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:14159887G>T	uc002mxx.2	+	9	1659	c.1236G>T	c.(1234-1236)GAG>GAT	p.E412D		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	412	Extracellular (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						GGTTCAGGGAGGAATTAGGTA	0.602											OREG0025303	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.23904e-05	0.184627	1.27548e-05	5	66										T	14159887	G	T	14159887	3	4	73	1	0	0	0	0	1	0	0	0	7681	991	35	4	1270	4	IL27RA	19	14159887	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	7682957	14159887	44969096	151	22530										
CEACAM5	1048	broad.mit.edu	37	chr19	42222226	42222226	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	acatcactgagaagaacagcGgactctatacctgccaggcc	9	13	2	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:42222226G>A	uc002ork.2	+	6	1538	c.1417G>A	c.(1417-1419)GGA>AGA	p.G473R	CEACAM5_uc002orj.1_Missense_Mutation_p.G472R|CEACAM5_uc002orl.2_Missense_Mutation_p.G473R	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	473	Ig-like 5.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GAAGAACAGCGGACTCTATAC	0.502													0	0	0	0.150653	0	4	79										A	42222226	G	A	42222226	3	1	73	1	0	0	0	0	1	0	0	0	3195	1117	39	2	1439	2	CEACAM5	19	42222226	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	28062339	42222226	16906757	152	22531										
CLPTM1	1209	broad.mit.edu	37	chr19	45496010	45496010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cacagcagcaggggccctcaCgcccacacctgcacccacca	8	21	1	0	rs141261045		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:45496010C>T	uc002pai.2	+	14	1880	c.1865C>T	c.(1864-1866)ACG>ATG	p.T622M	CLPTM1_uc010xxf.1_Missense_Mutation_p.T520M|CLPTM1_uc010xxg.1_Missense_Mutation_p.T608M	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	622	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GGGGCCCTCACGCCCACACCT	0.711													0	0	0	0.217242	0	6	70										T	45496010	C	T	45496010	3	4	73	1	0	0	0	0	1	0	0	0	3554	536	19	2	1919	2	CLPTM1	19	45496010	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	3273784	45496010	13632973	153	22532										
PRR12	57479	broad.mit.edu	37	chr19	50102618	50102618	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gaccacaacagcctggactcGagcctgactcgggagaagat	12	12	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:50102618G>A	uc002poo.3	+	5	3768	c.3768G>A	c.(3766-3768)TCG>TCA	p.S1256S		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	435	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GCCTGGACTCGAGCCTGACTC	0.567													0	0	0	0.217242	0	6	34										A	50102618	G	A	50102618	2	1	73	1	0	0	0	0	0	0	0	1	12584	1045	37	1		1	PRR12	19	50102618	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	4606608	50102618	9026365	154	22533										
ZNF432	9668	broad.mit.edu	37	chr19	52537344	52537344	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtatgagttcgctggtgtaCaacaagattgctcttaaagg	11	6	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:52537344C>T	uc002pyk.2	-	5	1906	c.1588G>A	c.(1588-1590)GTA>ATA	p.V530I		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	530	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CGCTGGTGTACAACAAGATTG	0.413													0	0	0	0.301197	0	44	108										T	52537344	C	T	52537344	3	4	73	1	0	0	0	0	1	0	0	0	17903	478	17	2	374	2	ZNF432	19	52537344	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	2434726	52537344	6591639	155	22534										
ZNF765	91661	broad.mit.edu	37	chr19	53911005	53911005	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gtcaacagcacaaggcaataGagaagtgttccatgcaggga	12	8	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:53911005G>C	uc010ydx.1	+	6	524	c.197G>C	c.(196-198)AGA>ACA	p.R66T	ZNF765_uc002qbm.2_Missense_Mutation_p.R66T|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		CAAGGCAATAGAGAAGTGTTC	0.358													0	0	0	0.279185	0	38	57										C	53911005	G	C	53911005	3	2	73	1	0	0	0	0	1	0	0	0	18136	942	33	1	207	1	ZNF765	19	53911005	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	1373661	53911005	5217978	156	22535										
LILRB2	10288	broad.mit.edu	37	chr19	54783434	54783434	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cacctgtgactcacactggaGggtcacccttcctcctgagg	10	15	2	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:54783434G>T	uc002qfb.2	-	5	690	c.424C>A	c.(424-426)CTC>ATC	p.L142I	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.L142I|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.L142I|LILRB2_uc010yet.1_Missense_Mutation_p.L26I|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	142	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACACTGGAGGGTCACCCTT	0.582													1	0	4.26978e-12	0.279207	4.67007e-12	22	146										T	54783434	G	T	54783434	3	4	73	1	0	0	0	0	1	0	0	0	8791	1000	35	4	1412	4	LILRB2	19	54783434	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	872429	54783434	4345549	157	22536										
PTPRH	5794	broad.mit.edu	37	chr19	55716720	55716720	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tggcatttcgagtctcccggGagctgttgattccattcttt	10	10	2	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:55716720G>C	uc002qjq.2	-	4	666	c.593C>G	c.(592-594)TCC>TGC	p.S198C	PTPRH_uc010esv.2_Intron|PTPRH_uc002qjs.2_Missense_Mutation_p.S205C	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	198	Fibronectin type-III 2.|Extracellular (Potential).				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGTCTCCCGGGAGCTGTTGAT	0.507													0	0	0	0.27861	0	8	159										C	55716720	G	C	55716720	3	2	73	1	0	0	0	0	1	0	0	0	12803	1174	41	1	2822	1	PTPRH	19	55716720	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	933286	55716720	3412263	158	22537										
ZNF470	388566	broad.mit.edu	37	chr19	57089446	57089446	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	taaggccttcagtcagattgCacaccttgttcagcaccaga	8	12	3	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:57089446C>T	uc002qnl.3	+	6	2325	c.1649C>T	c.(1648-1650)GCA>GTA	p.A550V	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	550	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGTCAGATTGCACACCTTGTT	0.448													0	0	0	0.144211	0	29	64										T	57089446	C	T	57089446	3	4	73	1	0	0	0	0	1	0	0	0	17926	710	25	2	1663	2	ZNF470	19	57089446	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	1372726	57089446	2039537	159	22538										
SERINC3	10955	broad.mit.edu	37	chr20	43139962	43139962	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agcccccagggatgtagaaaGagccaaccatgattccaata	9	11	0	3			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr20:43139962G>C	uc002xme.2	-	4	577	c.443C>G	c.(442-444)TCT>TGT	p.S148C	SERINC3_uc002xmf.1_Missense_Mutation_p.S148C|SERINC3_uc010ggs.1_Missense_Mutation_p.S141C|SERINC3_uc010zwp.1_Missense_Mutation_p.S93C	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	148	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GATGTAGAAAGAGCCAACCAT	0.353													0	0	0	0.279207	0	20	22										C	43139962	G	C	43139962	3	2	73	1	0	0	0	0	1	0	0	0	14081	942	33	1	1006	1	SERINC3	20	43139962	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		43139962	19885558	160	22539										
ZNF334	55713	broad.mit.edu	37	chr20	45132865	45132865	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttacttacctgggtagttctGatttgagaattcctccacta	7	9	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr20:45132865G>C	uc002xsc.2	-	4	413	c.229C>G	c.(229-231)CAG>GAG	p.Q77E	ZNF334_uc002xsa.2_Missense_Mutation_p.Q100E|ZNF334_uc002xsb.2_Missense_Mutation_p.Q39E|ZNF334_uc002xsd.2_Missense_Mutation_p.Q39E|ZNF334_uc010ghl.2_Missense_Mutation_p.Q76E	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GGGTAGTTCTGATTTGAGAAT	0.408													0	0	0	0.204396	0	16	25										C	45132865	G	C	45132865	3	2	73	1	0	0	0	0	1	0	0	0	17848	1299	45	1	1821	1	ZNF334	20	45132865	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	1992903	45132865	17892655	161	22540										
TRPM2	7226	broad.mit.edu	37	chr21	45861676	45861676	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	accctcctccagaaggcagcCgctgagttcggggctcacta	11	15	1	2	rs147981149		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr21:45861676C>T	uc002zet.1	+	33	4701	c.4488C>T	c.(4486-4488)GCC>GCT	p.A1496A	TRPM2_uc002zeu.1_Silent_p.A1496A|TRPM2_uc002zew.1_Silent_p.A1496A|TRPM2_uc010gpt.1_Silent_p.A1546A|TRPM2_uc002zex.1_Silent_p.A1282A|TRPM2_uc002zey.1_Silent_p.A975A|TRPM2_uc011aff.1_Silent_p.A177A	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1496	Nudix hydrolase.|Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGAAGGCAGCCGCTGAGTTCG	0.642													0	0	0	0.26419	0	21	20										T	45861676	C	T	45861676	2	4	73	1	0	0	0	0	0	0	0	1	16583	639	23	2		2	TRPM2	21	45861676	Silent	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		45861676	2268219	162	22541										
CYTSA	23384	broad.mit.edu	37	chr22	24720319	24720319	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agtgacatgaaagaaaccatCtttgaacttgaagatgaagt	9	5	1	7			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:24720319C>G	uc002zzw.2	+	6	2377	c.2070C>G	c.(2068-2070)ATC>ATG	p.I690M	CYTSA_uc002zzv.3_Missense_Mutation_p.I690M|CYTSA_uc011ajq.1_Missense_Mutation_p.I690M	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	690	Potential.				cell cycle|cell division						0						AAGAAACCATCTTTGAACTTG	0.328													0	0	0	0.204396	0	18	28										G	24720319	C	G	24720319	3	3	73	1	0	0	0	0	1	0	0	0	4209	903	32	1	2084	1	CYTSA	22	24720319	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08		24720319	26584247	163	22542										
NOL12	79159	broad.mit.edu	37	chr22	38084997	38084997	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tgctcgggctgaccccacctGaggtgggtcccagtctcagc	13	15	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:38084997G>A	uc003atp.2	+	4	435	c.379G>A	c.(379-381)GAG>AAG	p.E127K	NOL12_uc011anm.1_Missense_Mutation_p.E127K|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	127						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					GACCCCACCTGAGGTGGGTCC	0.657													0	0	0	0.144211	0	27	72										A	38084997	G	A	38084997	3	1	73	1	0	0	0	0	1	0	0	0	10522	1291	45	1	393	1	NOL12	22	38084997	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	13364678	38084997	13219569	164	22543										
ATF4	468	broad.mit.edu	37	chr22	39918553	39918553	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	gccaaggagatccagtacctGaaagatttgatagaagaggt	12	6	0	6			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:39918553G>A	uc003axz.2	+	3	1282	c.1002G>A	c.(1000-1002)CTG>CTA	p.L334L	ATF4_uc011aol.1_Silent_p.L246L|ATF4_uc003aya.2_Silent_p.L334L	NM_182810	NP_877962	P18848	ATF4_HUMAN	activating transcription factor 4	334	Leucine-zipper.|Interaction with GABBR1 (By similarity).|				cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.04)					TCCAGTACCTGAAAGATTTGA	0.512													0	0	0	0.115264	0	3	17										A	39918553	G	A	39918553	2	1	73	1	0	0	0	0	0	0	0	1	1082	1277	45	1		1	ATF4	22	39918553	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	1833556	39918553	11386013	165	22544										
MPPED1	758	broad.mit.edu	37	chr22	43831096	43831096	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ctggggacttcactgagctgGggctcccgagcgaggtgaag	17	10	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:43831096G>T	uc011apv.1	+	3	590	c.367G>T	c.(367-369)GGG>TGG	p.G123W	MPPED1_uc011apw.1_Missense_Mutation_p.G17W|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.G123W|MPPED1_uc011apz.1_Missense_Mutation_p.G156W	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	123							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CACTGAGCTGGGGCTCCCGAG	0.667													1	0	3.52763e-06	0.160694	3.68559e-06	17	35										T	43831096	G	T	43831096	3	4	73	1	0	0	0	0	1	0	0	0	9741	1232	43	4	373	4	MPPED1	22	43831096	Missense_Mutation	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08	3912543	43831096	7473470	166	22545										
MOV10L1	54456	broad.mit.edu	37	chr22	50553619	50553620	+	Frame_Shift_Ins	INS	-	-	G													0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	agatgacagagcctgagcctINSggggggcttgtccctccagg							TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:50553619_50553620insG	uc003bjj.2	+	8	1286_1287	c.1203_1204insG	c.(1201-1206)CCTGGGfs	p.P401fs	MOV10L1_uc003bjk.3_Frame_Shift_Ins_p.P401fs|MOV10L1_uc011arp.1_Frame_Shift_Ins_p.P381fs|MOV10L1_uc011arq.1_Frame_Shift_Ins_p.P162fs|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	401_402					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGCCTGAGCCTGGGGGGCTTGT	0.46																		74	95	---	---								G	50553620	-	G	50553619	7	5	73	1	0	1	1	0	0	0	0	0	9719	1567	55	0	1274	0	MOV10L1	22	50553619	Frame_Shift_Ins	INS	-	TCGA-FD-A3B5-01A-11D-A20D-08	6722523	50553619	750947	167	22546										
ARSH	347527	broad.mit.edu	37	chrX	2928167	2928167	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ccaagtcgggctgccttcctGaccggccggtaccccatcag	11	17	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:2928167G>C	uc011mhj.1	+	2	189	c.189G>C	c.(187-189)CTG>CTC	p.L63L		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	63						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CTGCCTTCCTGACCGGCCGGT	0.502													0	0	0	0.115264	0	3	19										C	2928167	G	C	2928167	2	2	73	1	0	0	0	0	0	0	0	1	993	1277	45	1		1	ARSH	23	2928167	Silent	SNP	G	TCGA-FD-A3B5-01A-11D-A20D-08		2928167	152342393	168	22547										
KDM6A	7403	broad.mit.edu	37	chrX	44949073	44949073	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	ttccagtgtataggtttattCagcgacctggagatttggtc	11	7	1	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:44949073C>T	uc004dge.3	+	25	4009	c.3634C>T	c.(3634-3636)CAG>TAG	p.Q1212*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q1264*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q1167*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q1219*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q916*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q851*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1212	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGGTTTATTCAGCGACCTGG	0.398			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.153744	0	32	6										T	44949073	C	T	44949073	4	4	73	1	0	0	0	0	0	1	0	0	8137	827	29	1	3732	1	KDM6A	23	44949073	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	42020906	44949073	110321487	169	22548										
TFE3	7030	broad.mit.edu	37	chrX	48895739	48895739	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tacctccttctctgagctggAcccgatggtgagcagcgcca	11	14	1	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:48895739A>C	uc004dmb.3	-	4	1001	c.763T>G	c.(763-765)TCC>GCC	p.S255A	TFE3_uc004dmc.3_Missense_Mutation_p.S150A|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	255					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						TCTGAGCTGGACCCGATGGTG	0.587			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								0	0	0	0.058154	0	9	19										C	48895739	A	C	48895739	3	2	73	1	0	0	0	0	1	0	0	0	15797	275	10	5	992	5	TFE3	23	48895739	Missense_Mutation	SNP	A	TCGA-FD-A3B5-01A-11D-A20D-08	3946666	48895739	106374821	170	22549										
WNK3	65267	broad.mit.edu	37	chrX	54321194	54321194	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	cagccagcaggcttcttctcTcttgtcttctttattggcgt	8	12	5	0			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:54321194T>G	uc004dtd.1	-	8	1924	c.1485A>C	c.(1483-1485)AGA>AGC	p.R495S	WNK3_uc004dtc.1_Missense_Mutation_p.R495S	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	495					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GCTTCTTCTCTCTTGTCTTCT	0.458													0	0	0	0.27861	0	8	24										G	54321194	T	G	54321194	3	3	73	1	0	0	0	0	1	0	0	0	17376	1548	54	5	3985	5	WNK3	23	54321194	Missense_Mutation	SNP	T	TCGA-FD-A3B5-01A-11D-A20D-08	5425455	54321194	100949366	171	22550										
VSIG4	11326	broad.mit.edu	37	chrX	65253367	65253367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	tctcacgacttggttgccatCaggagtctgccaggtgactt	11	11	3	1			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:65253367C>G	uc004dwh.2	-	2	488	c.361G>C	c.(361-363)GAT>CAT	p.D121H	VSIG4_uc004dwi.2_Missense_Mutation_p.D121H|VSIG4_uc010nkq.1_Missense_Mutation_p.D121H|VSIG4_uc004dwj.2_Missense_Mutation_p.D121H|VSIG4_uc011moy.1_Missense_Mutation_p.D121H|VSIG4_uc004dwk.2_Missense_Mutation_p.D121H|VSIG4_uc004dwl.2_Missense_Mutation_p.D17H	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	121	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						TGGTTGCCATCAGGAGTCTGC	0.498													0	0	0	0.132662	0	13	115										G	65253367	C	G	65253367	3	3	73	1	0	0	0	0	1	0	0	0	17222	826	29	1	870	1	VSIG4	23	65253367	Missense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	10932173	65253367	90017193	172	22551										
STAG2	10735	broad.mit.edu	37	chrX	123200110	123200110	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.427745664739884	74	5.74546679737382e-25	3.58667607621736	4.5506625891947	2.90173829068083	0.636235553476684	0.751914745017899	53	aaaatggagacatgcctgagCaggtttttatttatttgcta	9	5	0	2			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:123200110C>T	uc004etz.3	+	21	2521	c.2182C>T	c.(2182-2184)CAG>TAG	p.Q728*	STAG2_uc004eua.2_Nonsense_Mutation_p.Q728*|STAG2_uc004eub.2_Nonsense_Mutation_p.Q728*|STAG2_uc004euc.2_Nonsense_Mutation_p.Q728*|STAG2_uc004eud.2_Nonsense_Mutation_p.Q728*|STAG2_uc004eue.2_Nonsense_Mutation_p.Q728*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	728					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CATGCCTGAGCAGGTTTTTAT	0.303													0	0	0	0.323286	0	60	17										T	123200110	C	T	123200110	4	4	73	1	0	0	0	0	0	1	0	0	15242	711	25	2	2260	2	STAG2	23	123200110	Nonsense_Mutation	SNP	C	TCGA-FD-A3B5-01A-11D-A20D-08	57946743	123200110	32070450	173	22552										
C1orf86	199990	broad.mit.edu	37	chr1	2121153	2121153	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gctcttggatggcgctcaccAcgtcacgtcttctgtgcttt	10	13	5	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:2121153A>G	uc001aiy.2	-	4	564	c.538T>C	c.(538-540)TGG>CGG	p.W180R	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Intron|uc001aiz.1_5'Flank	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	180											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GGCGCTCACCACGTCACGTCT	0.706													0	0	0	0.020292	0	12	40										G	2121153	A	G	2121153	3	3	74	1	0	0	0	0	1	0	0	0	2063	159	6	5	248	5	C1orf86	1	2121153	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08		2121153	247129468	1	22553										
SYF2	25949	broad.mit.edu	37	chr1	25551554	25551554	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggaaggcacatgtgttccatGaagaagactattggatgttg	13	5	0	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:25551554G>A	uc001bjt.1	-	6	560	c.505C>T	c.(505-507)CAT>TAT	p.H169Y	SYF2_uc001bju.1_Missense_Mutation_p.H127Y	NM_015484	NP_056299	O95926	SYF2_HUMAN	SYF2 homolog, RNA splicing factor isoform 1	169						catalytic step 2 spliceosome					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		TGTGTTCCATGAAGAAGACTA	0.373													0	0	0	0.036044	0	33	79										A	25551554	G	A	25551554	3	1	74	1	0	0	0	0	1	0	0	0	15434	1290	45	1	234	1	SYF2	1	25551554	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	23430401	25551554	223699067	2	22554										
PIGV	55650	broad.mit.edu	37	chr1	27124128	27124128	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cacttgcttcaggatcaagaGccgctgttgagatccttaaa	9	10	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:27124128G>A	uc001bmz.2	+	4	1606	c.1275G>A	c.(1273-1275)GAG>GAA	p.E425E	PIGV_uc001bmy.2_Silent_p.E190E|PIGV_uc009vso.2_Missense_Mutation_p.A419T|PIGV_uc010ofg.1_Silent_p.E190E|PIGV_uc001bna.2_Silent_p.E425E	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	425	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		AGGATCAAGAGCCGCTGTTGA	0.488													0	0	0	0.016522	0	23	60										A	27124128	G	A	27124128	2	1	74	1	0	0	0	0	0	0	0	1	11901	962	34	2		2	PIGV	1	27124128	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1572574	27124128	222126493	3	22555										
ZMYM4	9202	broad.mit.edu	37	chr1	35864515	35864515	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aatcagaggcagtatctactCcacatagctgggaggaagag	12	8	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:35864515C>T	uc001byt.2	+	22	3384	c.3304C>T	c.(3304-3306)CCA>TCA	p.P1102S	ZMYM4_uc009vuu.2_Missense_Mutation_p.P1070S|ZMYM4_uc001byu.2_Missense_Mutation_p.P778S|ZMYM4_uc009vuv.2_Missense_Mutation_p.P841S	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1102					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGTATCTACTCCACATAGCTG	0.398													0	0	0	0.008871	0	14	84										T	35864515	C	T	35864515	3	4	74	1	0	0	0	0	1	0	0	0	17699	855	30	1	3390	1	ZMYM4	1	35864515	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	8740387	35864515	213386106	4	22556										
LRRC41	10489	broad.mit.edu	37	chr1	46746098	46746098	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttgcaaaacaagcccaaaatCctggggagaggcaaaggtgg	13	8	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:46746098C>T	uc001cpn.2	-	6	1935	c.1891G>A	c.(1891-1893)GAT>AAT	p.D631N	LRRC41_uc010omb.1_Missense_Mutation_p.D631N	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	631	LRR 4.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGCCCAAAATCCTGGGGAGAG	0.572													0	0	0	0.012319	0	19	103										T	46746098	C	T	46746098	3	4	74	1	0	0	0	0	1	0	0	0	8999	855	30	1	567	1	LRRC41	1	46746098	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10881583	46746098	202504523	5	22557										
OSBPL9	114883	broad.mit.edu	37	chr1	52251500	52251500	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttctccaaatgacaagaagtCtttttgctcaattgaagggg	9	7	3	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:52251500C>G	uc001cst.2	+	21	1869	c.1850C>G	c.(1849-1851)TCT>TGT	p.S617C	OSBPL9_uc001css.2_Missense_Mutation_p.S622C|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.S618C|OSBPL9_uc001csu.2_Missense_Mutation_p.S627C|OSBPL9_uc001csv.2_Missense_Mutation_p.S452C|OSBPL9_uc001csw.2_Missense_Mutation_p.S604C|OSBPL9_uc001csy.2_Missense_Mutation_p.S439C|OSBPL9_uc001csz.2_Missense_Mutation_p.S439C|OSBPL9_uc001cta.2_Missense_Mutation_p.S507C|OSBPL9_uc001ctb.2_Missense_Mutation_p.S402C	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	617					lipid transport		lipid binding			central_nervous_system(1)	1						GACAAGAAGTCTTTTTGCTCA	0.383													0	0	0	0.037714	0	23	113										G	52251500	C	G	52251500	3	3	74	1	0	0	0	0	1	0	0	0	11284	913	32	1	2036	1	OSBPL9	1	52251500	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5505402	52251500	196999121	6	22558										
ZCCHC11	23318	broad.mit.edu	37	chr1	52991393	52991393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctttgtccacagaagtaaagGagcttggaattttttttcca	8	7	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:52991393G>A	uc001ctx.2	-	2	794	c.560C>T	c.(559-561)TCC>TTC	p.S187F	ZCCHC11_uc001cty.2_Missense_Mutation_p.S187F|ZCCHC11_uc001ctz.2_Missense_Mutation_p.S187F|ZCCHC11_uc009vze.1_Missense_Mutation_p.S187F|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cub.2_Missense_Mutation_p.S187F|ZCCHC11_uc001cuc.2_RNA|ZCCHC11_uc001cud.2_Missense_Mutation_p.S187F	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	187					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AGAAGTAAAGGAGCTTGGAAT	0.413													0	0	0	0.012213	0	29	144										A	52991393	G	A	52991393	3	1	74	1	0	0	0	0	1	0	0	0	17577	1174	41	1	4493	1	ZCCHC11	1	52991393	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	739893	52991393	196259228	7	22559										
DOCK7	85440	broad.mit.edu	37	chr1	62993831	62993831	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	attgtttttaccgttgacgtGaggaggaaactgccaggcct	12	8	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:62993831G>A	uc001daq.2	-	31	3961	c.3927C>T	c.(3925-3927)CTC>CTT	p.L1309L	DOCK7_uc001dan.2_Silent_p.L1170L|DOCK7_uc001dao.2_Silent_p.L1170L|DOCK7_uc001dap.2_Silent_p.L1278L|DOCK7_uc001dam.2_Silent_p.L489L|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1309					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CCGTTGACGTGAGGAGGAAAC	0.413													0	0	0	0.013537	0	11	58										A	62993831	G	A	62993831	2	1	74	1	0	0	0	0	0	0	0	1	4692	1277	45	1		1	DOCK7	1	62993831	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	10002438	62993831	186256790	8	22560										
DNAJB4	11080	broad.mit.edu	37	chr1	78479241	78479241	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttatcattaaagacaaagatCatccaaaatttaaaagggat	5	5	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:78479241C>A	uc001dij.2	+	2	877	c.718C>A	c.(718-720)CAT>AAT	p.H240N	DNAJB4_uc010orn.1_Missense_Mutation_p.H125N	NM_007034	NP_008965	Q9UDY4	DNJB4_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 4	240					protein folding|response to heat|response to unfolded protein	cytoplasm|plasma membrane	heat shock protein binding|unfolded protein binding				0						AGACAAAGATCATCCAAAATT	0.323													1	0	9.57634e-11	0.01892	1.06179e-10	20	92										A	78479241	C	A	78479241	3	1	74	1	0	0	0	0	1	0	0	0	4622	826	29	3	724	3	DNAJB4	1	78479241	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	15485410	78479241	170771380	9	22561										
IFI44L	10964	broad.mit.edu	37	chr1	79102774	79102774	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttttatcacctctccatctCtgaaggacaggattcactgt	6	12	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:79102774C>G	uc010oro.1	+	6	1113	c.934C>G	c.(934-936)CTG>GTG	p.L312V	IFI44L_uc010orp.1_Missense_Mutation_p.L49V|IFI44L_uc010orq.1_Missense_Mutation_p.L49V	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	312						cytoplasm					0						CTCTCCATCTCTGAAGGACAG	0.368													0	0	0	0.030466	0	29	158										G	79102774	C	G	79102774	3	3	74	1	0	0	0	0	1	0	0	0	7518	912	32	1	952	1	IFI44L	1	79102774	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	623533	79102774	170147847	10	22562										
CCBL2	56267	broad.mit.edu	37	chr1	89414843	89414843	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gggttttaggccaacactttCaagtaaacgtaccatccgat	8	10	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:89414843C>T	uc001dmp.2	-	11	1449	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K	CCBL2_uc001dmq.2_Missense_Mutation_p.E324K|CCBL2_uc001dmr.2_Missense_Mutation_p.E194K	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	358					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCAACACTTTCAAGTAAACGT	0.373													0	0	0	0.012319	0	18	73										T	89414843	C	T	89414843	3	4	74	1	0	0	0	0	1	0	0	0	2733	835	29	1	308	1	CCBL2	1	89414843	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10312069	89414843	159835778	11	22563										
ABCD3	5825	broad.mit.edu	37	chr1	94933515	94933515	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgctgttatgctggtgtctcGaacatattgtgatgtttgga	12	5	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:94933515G>C	uc001dqn.3	+	4	389	c.287G>C	c.(286-288)CGA>CCA	p.R96P	ABCD3_uc001dqm.3_Missense_Mutation_p.R96P|ABCD3_uc010oto.1_Missense_Mutation_p.R120P|ABCD3_uc010otp.1_Missense_Mutation_p.R23P|ABCD3_uc009wdr.2_Missense_Mutation_p.R96P	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	96	ABC transmembrane type-1.|Targeting to peroxisomes.|Helical; (Potential).|Interaction with PEX19.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		CTGGTGTCTCGAACATATTGT	0.313													0	0	0	0.008291	0	7	55										C	94933515	G	C	94933515	3	2	74	1	0	0	0	0	1	0	0	0	62	1058	37	1	301	1	ABCD3	1	94933515	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5518672	94933515	154317106	12	22564										
COL11A1	1301	broad.mit.edu	37	chr1	103483426	103483426	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggggccttgtagacctggagGacccataataccctatagag	12	10	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:103483426G>A	uc001dul.2	-	11	1681	c.1363C>T	c.(1363-1365)CCT>TCT	p.P455S	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.P467S|COL11A1_uc001dun.2_Missense_Mutation_p.P416S|COL11A1_uc009weh.2_Missense_Mutation_p.P339S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	455	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AGACCTGGAGGACCCATAATA	0.418													0	0	0	0.01441	0	44	94										A	103483426	G	A	103483426	3	1	74	1	0	0	0	0	1	0	0	0	3667	1174	41	1	4285	1	COL11A1	1	103483426	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	8549911	103483426	145767195	13	22565										
NTNG1	22854	broad.mit.edu	37	chr1	108023313	108023313	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgcgctgcctgtgcccggccGcatacacgggcatcctctgc	12	17	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:108023313G>T	uc001dvh.3	+	8	2189	c.1471G>T	c.(1471-1473)GCA>TCA	p.A491S	NTNG1_uc001dvf.3_Missense_Mutation_p.A432S|NTNG1_uc010out.1_Missense_Mutation_p.A457S|NTNG1_uc001dvc.3_Missense_Mutation_p.A390S|NTNG1_uc001dvi.2_Silent_p.P58P|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_Missense_Mutation_p.R53L	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	491					axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTGCCCGGCCGCATACACGGG	0.687													1	0	1.58986e-06	0.008291	1.67186e-06	7	50										T	108023313	G	T	108023313	3	4	74	1	0	0	0	0	1	0	0	0	10704	1087	38	4	1631	4	NTNG1	1	108023313	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4539887	108023313	141227308	14	22566										
SYT6	148281	broad.mit.edu	37	chr1	114640500	114640500	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgatctcattgtggcccactCtgagggagaaacaaaagtcc	10	10	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:114640500C>G	uc001eev.2	-	6	1360	c.1110_splice	c.e6-1	p.R370_splice	SYT6_uc001eeu.2_Splice_Site_p.R15_splice	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI						acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGCCCACTCTGAGGGAGAA	0.577													0	0	0	0.010504	0	15	77										G	114640500	C	G	114640500	5	3	74	1	0	0	0	0	0	0	1	0	15475	927	32	1	176	1	SYT6	1	114640500	Splice_Site	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6617187	114640500	134610121	15	22567										
WDR3	10885	broad.mit.edu	37	chr1	118496158	118496158	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aagaaaactattgaaacagtGaaagcagtaagttgatatag	9	3	0	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:118496158G>A	uc010oxe.1	+	21	2328	c.2262G>A	c.(2260-2262)GTG>GTA	p.V754V	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	754						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTGAAACAGTGAAAGCAGTAA	0.333													0	0	0	0.010504	0	17	40										A	118496158	G	A	118496158	2	1	74	1	0	0	0	0	0	0	0	1	17282	1277	45	1		1	WDR3	1	118496158	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3855658	118496158	130754463	16	22568										
WDR3	10885	broad.mit.edu	37	chr1	118496687	118496687	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aagaaactgcaaaaatgaagGaacacaaagccatttgtaaa	7	6	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:118496687G>A	uc010oxe.1	+	22	2392	c.2326G>A	c.(2326-2328)GAA>AAA	p.E776K	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	776						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AAAAATGAAGGAACACAAAGC	0.398													0	0	0	0.017118	0	25	56										A	118496687	G	A	118496687	3	1	74	1	0	0	0	0	1	0	0	0	17282	1175	41	1	2408	1	WDR3	1	118496687	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	529	118496687	130753934	17	22569										
RUSC1	23623	broad.mit.edu	37	chr1	155291967	155291967	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtgatgaggatgcccaccctCagcccagtatcatccccctg	9	16	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:155291967C>T	uc001fkj.2	+	2	632	c.403C>T	c.(403-405)CAG>TAG	p.Q135*	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Nonsense_Mutation_p.Q135*|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	135						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TGCCCACCCTCAGCCCAGTAT	0.622													0	0	0	0.016723	0	11	70										T	155291967	C	T	155291967	4	4	74	1	0	0	0	0	0	1	0	0	13750	827	29	1	405	1	RUSC1	1	155291967	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	36795280	155291967	93958654	18	22570										
GON4L	54856	broad.mit.edu	37	chr1	155791331	155791331	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gctaccacgtgttcatttgtGattacttcctggagaaagat	9	8	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:155791331G>A	uc001flz.2	-	5	994	c.897C>T	c.(895-897)ATC>ATT	p.I299I	GON4L_uc001fly.1_Silent_p.I299I|GON4L_uc009wrh.1_Silent_p.I299I|GON4L_uc001fma.1_Silent_p.I299I|GON4L_uc001fmc.2_Silent_p.I299I|GON4L_uc001fmd.3_Silent_p.I299I|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Silent_p.I127I|GON4L_uc001fmf.2_5'UTR	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	299					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTTCATTTGTGATTACTTCCT	0.393													0	0	0	0.028581	0	16	72										A	155791331	G	A	155791331	2	1	74	1	0	0	0	0	0	0	0	1	6572	1280	45	1		1	GON4L	1	155791331	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	499364	155791331	93459290	19	22571										
TMCO1	54499	broad.mit.edu	37	chr1	165737466	165737466	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tccacttctgccttcagtctCttgtacttgtctgtcctgta	6	13	4	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:165737466C>G	uc001gdj.3	-	2	260	c.111G>C	c.(109-111)AAG>AAC	p.K37N	TMCO1_uc001gdl.3_5'UTR|TMCO1_uc001gdm.3_5'UTR|TMCO1_uc001gdk.3_Missense_Mutation_p.K25N|TMCO1_uc001gdn.3_RNA|uc001gdo.2_5'Flank	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	37	Potential.					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CCTTCAGTCTCTTGTACTTGT	0.363													0	0	0	0.00308	0	6	41										G	165737466	C	G	165737466	3	3	74	1	0	0	0	0	1	0	0	0	15992	912	32	1	479	1	TMCO1	1	165737466	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	9946135	165737466	83513155	20	22572										
F5	2153	broad.mit.edu	37	chr1	169551671	169551671	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agtatatttcaggcttacctGaaatggtagattgtggtttt	10	4	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:169551671G>A	uc001ggg.1	-	2	393	c.248C>T	c.(247-249)TCA>TTA	p.S83L	F5_uc010plr.1_Intron	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	83	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGGCTTACCTGAAATGGTAGA	0.264													0	0	0	0.00308	0	8	16										A	169551671	G	A	169551671	3	1	74	1	0	0	0	0	1	0	0	0	5348	1294	45	1	6522	1	F5	1	169551671	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3814205	169551671	79698950	21	22573										
PAPPA2	60676	broad.mit.edu	37	chr1	176564245	176564245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcccccactctgtgggcaaaCagtctgtgacaatgtggaat	11	11	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:176564245C>T	uc001gkz.2	+	3	2669	c.1505C>T	c.(1504-1506)ACA>ATA	p.T502I	PAPPA2_uc001gky.1_Missense_Mutation_p.T502I|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	502	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGTGGGCAAACAGTCTGTGAC	0.522													0	0	0	0.014758	0	4	39										T	176564245	C	T	176564245	3	4	74	1	0	0	0	0	1	0	0	0	11433	478	17	2	1511	2	PAPPA2	1	176564245	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7012574	176564245	72686376	22	22574										
UCHL5	51377	broad.mit.edu	37	chr1	193020927	193020927	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctctaaactccatatttcttCtacttgggctcctcggcaac	5	14	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:193020927C>A	uc001gsm.2	-	2	228	c.97G>T	c.(97-99)GAA>TAA	p.E33*	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Nonsense_Mutation_p.E33*|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Nonsense_Mutation_p.E33*|UCHL5_uc001gsq.2_Nonsense_Mutation_p.E33*|UCHL5_uc010pow.1_5'UTR|UCHL5_uc010pox.1_5'UTR	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	33					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						CATATTTCTTCTACTTGGGCT	0.249													1	0	3.90053e-15	0.012213	4.36431e-15	23	101										A	193020927	C	A	193020927	4	1	74	1	0	0	0	0	0	1	0	0	16919	922	32	3	932	3	UCHL5	1	193020927	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	16456682	193020927	56229694	23	22575										
CRB1	23418	broad.mit.edu	37	chr1	197297651	197297651	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agacaatgattgttcttgttCagacacagccaataatttgg	8	7	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:197297651C>T	uc001gtz.2	+	2	305	c.170C>T	c.(169-171)TCA>TTA	p.S57L	CRB1_uc010poz.1_5'UTR|CRB1_uc001gty.1_Missense_Mutation_p.S57L|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.S57L|CRB1_uc010ppb.1_Missense_Mutation_p.S57L	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	57	Extracellular (Potential).|EGF-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TGTTCTTGTTCAGACACAGCC	0.403													0	0	0	0.004482	0	9	44										T	197297651	C	T	197297651	3	4	74	1	0	0	0	0	1	0	0	0	3848	838	29	1	176	1	CRB1	1	197297651	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4276724	197297651	51952970	24	22576										
ZNF281	23528	broad.mit.edu	37	chr1	200377122	200377122	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cattgtccaaaacactgacaCctgcagactgaatgacagac	7	12	0	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:200377122C>T	uc001gve.2	-	2	1819	c.1712G>A	c.(1711-1713)GGT>GAT	p.G571D	ZNF281_uc001gvf.1_Missense_Mutation_p.G571D|ZNF281_uc001gvg.1_Missense_Mutation_p.G535D	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	571					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						AACACTGACACCTGCAGACTG	0.413													0	0	0	0.02938	0	5	18										T	200377122	C	T	200377122	3	4	74	1	0	0	0	0	1	0	0	0	17815	507	18	2	979	2	ZNF281	1	200377122	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3079471	200377122	48873499	25	22577										
MYOG	4656	broad.mit.edu	37	chr1	203054922	203054922	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctggacagtgctcgggggtCcccagccccttgtcctcaag	12	16	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:203054922C>A	uc001gzd.2	-	1	456	c.168G>T	c.(166-168)GGG>GGT	p.G56G		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	56					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						GCTCGGGGGTCCCCAGCCCCT	0.697													1	0	1.28384e-07	0.012319	1.37769e-07	17	48										A	203054922	C	A	203054922	2	1	74	1	0	0	0	0	0	0	0	1	10090	842	30	3		3	MYOG	1	203054922	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2677800	203054922	46195699	26	22578										
OPTC	26254	broad.mit.edu	37	chr1	203465269	203465269	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	attcctttgaagttctgcctCtgcggaatgatgtcctgaac	9	10	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:203465269C>T	uc001gzu.1	+	2	252	c.136C>T	c.(136-138)CTG>TTG	p.L46L		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	46						proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			AGTTCTGCCTCTGCGGAATGA	0.542													0	0	0	0.007413	0	16	51										T	203465269	C	T	203465269	2	4	74	1	0	0	0	0	0	0	0	1	10888	912	32	1		1	OPTC	1	203465269	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	410347	203465269	45785352	27	22579										
NFASC	23114	broad.mit.edu	37	chr1	204985457	204985457	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gatgaggacaacaagcccctGcagggcagtcagacatctct	11	12	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:204985457G>A	uc001hbj.2	+	30	3841	c.3513G>A	c.(3511-3513)CTG>CTA	p.L1171L	NFASC_uc010pra.1_Silent_p.L1105L|NFASC_uc001hbi.2_Silent_p.L1100L|NFASC_uc010prb.1_Silent_p.L1120L|NFASC_uc010prc.1_Silent_p.L671L|NFASC_uc001hbl.1_Silent_p.L247L|NFASC_uc001hbm.1_Silent_p.L194L|NFASC_uc009xbh.1_Missense_Mutation_p.C26Y|NFASC_uc001hbo.1_Missense_Mutation_p.C47Y	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1278	Cytoplasmic (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACAAGCCCCTGCAGGGCAGTC	0.592													0	0	0	0.01441	0	54	156										A	204985457	G	A	204985457	2	1	74	1	0	0	0	0	0	0	0	1	10359	1306	46	2		2	NFASC	1	204985457	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1520188	204985457	44265164	28	22580										
FAIM3	9214	broad.mit.edu	37	chr1	207087417	207087417	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccctctacctttacttctggGaggatcctcagggcccccga	9	16	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:207087417G>A	uc001hey.2	-	2	239	c.60C>T	c.(58-60)CTC>CTT	p.L20L	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_5'UTR|FAIM3_uc010psb.1_Silent_p.L20L	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	20	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					TTACTTCTGGGAGGATCCTCA	0.418													0	0	0	0.008871	0	19	86										A	207087417	G	A	207087417	2	1	74	1	0	0	0	0	0	0	0	1	5377	1161	41	1		1	FAIM3	1	207087417	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2101960	207087417	42163204	29	22581										
CR2	1380	broad.mit.edu	37	chr1	207640030	207640030	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aactaaagacaaagtggatgGaacctgggataaacctgctc	10	8	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:207640030G>T	uc001hfw.2	+	2	312	c.218G>T	c.(217-219)GGA>GTA	p.G73V	CR2_uc001hfv.2_Missense_Mutation_p.G73V|CR2_uc009xch.2_Missense_Mutation_p.G73V	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	73	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						AAAGTGGATGGAACCTGGGAT	0.408													1	0	3.27435e-08	0.020292	3.5448e-08	14	60										T	207640030	G	T	207640030	3	4	74	1	0	0	0	0	1	0	0	0	3842	1174	41	3	224	3	CR2	1	207640030	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	552613	207640030	41610591	30	22582										
MARK1	4139	broad.mit.edu	37	chr1	220792050	220792050	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccacagactgtgaaaatcttCtgaagaaattattagtcctg	7	8	2	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:220792050C>A	uc001hmn.3	+	9	1459	c.862C>A	c.(862-864)CTG>ATG	p.L288M	MARK1_uc009xdw.2_Missense_Mutation_p.L288M|MARK1_uc010pun.1_Missense_Mutation_p.L288M|MARK1_uc001hmm.3_Missense_Mutation_p.L266M	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	288	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TGAAAATCTTCTGAAGAAATT	0.328													1	0	0.00010058	0.013537	0.000103688	10	52										A	220792050	C	A	220792050	3	1	74	1	0	0	0	0	1	0	0	0	9312	912	32	3	896	3	MARK1	1	220792050	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	13152020	220792050	28458571	31	22583										
TTC13	79573	broad.mit.edu	37	chr1	231076227	231076227	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tccccgatgtctgtacagccGtgctgagggctgcagttgga	14	11	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:231076227G>A	uc001huf.3	-	7	779	c.748C>T	c.(748-750)CGG>TGG	p.R250W	TTC13_uc009xfi.2_Missense_Mutation_p.R197W|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.R197W|TTC13_uc009xfk.1_Missense_Mutation_p.R140W	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	250	TPR 3.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CTGTACAGCCGTGCTGAGGGC	0.423													0	0	0	0.020292	0	12	52										A	231076227	G	A	231076227	3	1	74	1	0	0	0	0	1	0	0	0	16677	1144	40	2	1902	2	TTC13	1	231076227	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	10284177	231076227	18174394	32	22584										
KCNK1	3775	broad.mit.edu	37	chr1	233807173	233807173	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgaccaactgtccttctcctCgatcacagaccaggcagctg	8	15	2	2	rs149408317		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:233807173C>T	uc010pxo.1	+	3	1076	c.908C>T	c.(907-909)TCG>TTG	p.S303L	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	303	Cytoplasmic (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TCCTTCTCCTCGATCACAGAC	0.493													0	0	0	0.024245	0	15	31										T	233807173	C	T	233807173	3	4	74	1	0	0	0	0	1	0	0	0	8058	893	31	1	918	1	KCNK1	1	233807173	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2730946	233807173	15443448	33	22585										
CEP170	9859	broad.mit.edu	37	chr1	243349256	243349256	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtctgtgcccaagactccctGaacttcttaataatgcagtt	7	11	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:243349256G>A	uc001hzs.2	-	10	1799	c.1391C>T	c.(1390-1392)TCA>TTA	p.S464L	CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	464						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			AAGACTCCCTGAACTTCTTAA	0.418													0	0	0	0.009096	0	4	43										A	243349256	G	A	243349256	3	1	74	1	0	0	0	0	1	0	0	0	3250	1294	45	1	3437	1	CEP170	1	243349256	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	9542083	243349256	5901365	34	22586										
KIF26B	55083	broad.mit.edu	37	chr1	245582962	245582962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acaatgcagacaagccttccGcctgcagtgtcccagcctcg	9	16	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:245582962G>A	uc001ibf.1	+	4	1521	c.1081G>A	c.(1081-1083)GCC>ACC	p.A361T	KIF26B_uc010pyq.1_Missense_Mutation_p.A361T	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	361					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAAGCCTTCCGCCTGCAGTGT	0.572													0	0	0	0.007413	0	15	56										A	245582962	G	A	245582962	3	1	74	1	0	0	0	0	1	0	0	0	8295	1087	38	2	1095	2	KIF26B	1	245582962	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2233706	245582962	3667659	35	22587										
KIF26B	55083	broad.mit.edu	37	chr1	245865906	245865906	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acatcacctccaggcgccggTagatgagccagacccttgtc	10	15	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:245865906T>C	uc001ibf.1	+	15	6765	c.6325T>C	c.(6325-6327)TAG>CAG	p.*2109Q		NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2109					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAGGCGCCGGTAGATGAGCCA	0.597													0	0	0	0.037714	0	19	55										C	245865906	T	C	245865906	4	2	74	1	0	0	0	0	0	0	0	0	8295	1651	57	5	6383	5	KIF26B	1	245865906	Nonstop_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	282944	245865906	3384715	36	22588										
OR2W3	343171	broad.mit.edu	37	chr1	248059565	248059565	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctacattgtgagggctgtgtTacaaattcggtcagcatcag	11	8	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr1:248059565T>G	uc001idp.1	+	3	946	c.677T>G	c.(676-678)TTA>TGA	p.L226*	OR2W3_uc010pzb.1_Nonsense_Mutation_p.L226*	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGGGCTGTGTTACAAATTCGG	0.532													0	0	0	0.011902	0	35	108										G	248059565	T	G	248059565	4	3	74	1	0	0	0	0	0	1	0	0	11033	1764	61	5	679	5	OR2W3	1	248059565	Nonsense_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	2193659	248059565	1191056	37	22589										
PDIA6	10130	broad.mit.edu	37	chr2	10952816	10952816	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcacctaccgagcaccaggaGagccatgccgagcgccgggc	14	16	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:10952816G>A	uc002rau.2	-	1	145	c.7C>T	c.(7-9)CTC>TTC	p.L3F	PDIA6_uc010yjg.1_5'UTR|PDIA6_uc002rav.2_Intron|PDIA6_uc010yjh.1_Intron|PDIA6_uc002raw.2_Intron	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	3					cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		AGCACCAGGAGAGCCATGCCG	0.687													0	0	0	0.014758	0	3	11										A	10952816	G	A	10952816	3	1	74	1	0	0	0	0	1	0	0	0	11672	942	33	1	1367	1	PDIA6	2	10952816	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		10952816	232246557	38	22590										
OTOF	9381	broad.mit.edu	37	chr2	26706500	26706500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcgttcggggggcaccccctCggggagcagcaagttcctgc	16	14	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:26706500C>T	uc002rhk.2	-	13	1349	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	408	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCACCCCCTCGGGGAGCAGC	0.602													0	0	0	0.004482	0	7	23										T	26706500	C	T	26706500	3	4	74	1	0	0	0	0	1	0	0	0	11303	893	31	1	5236	1	OTOF	2	26706500	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	15753684	26706500	216492873	39	22591										
VIT	5212	broad.mit.edu	37	chr2	36982074	36982074	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcttcatagtggtgtgcttGataattcaggagggaaaata	11	5	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:36982074G>C	uc002rpl.2	+	5	507	c.286G>C	c.(286-288)GAT>CAT	p.D96H	VIT_uc002rpk.2_Missense_Mutation_p.D89H|VIT_uc010ynf.1_Missense_Mutation_p.D89H|VIT_uc002rpm.2_Missense_Mutation_p.D89H|VIT_uc010ezv.2_Missense_Mutation_p.D89H|VIT_uc010ezw.2_Missense_Mutation_p.D89H	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	96	LCCL.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				TGGTGTGCTTGATAATTCAGG	0.393													0	0	0	0.036044	0	34	40										C	36982074	G	C	36982074	3	2	74	1	0	0	0	0	1	0	0	0	17168	1290	45	1	300	1	VIT	2	36982074	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	10275574	36982074	206217299	40	22592										
CALM2	805	broad.mit.edu	37	chr2	47389450	47389450	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caaacacacggaatgcttctCtaatttcttcttcactgtct	4	12	5	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:47389450C>G	uc002rvt.2	-	4	418	c.260G>C	c.(259-261)AGA>ACA	p.R87T	C2orf61_uc010fbd.2_Intron|CALM2_uc010fbe.2_Intron	NM_001743	NP_001734	P62158	CALM_HUMAN	calmodulin 2	87	EF-hand 3.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding	p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)		Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	GAATGCTTCTCTAATTTCTTC	0.368													0	0	0	0.004482	0	6	43										G	47389450	C	G	47389450	3	3	74	1	0	0	0	0	1	0	0	0	2585	913	32	1	201	1	CALM2	2	47389450	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10407376	47389450	195809923	41	22593										
FAM176A	84141	broad.mit.edu	37	chr2	75720637	75720637	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cccgggacgccgcctgcagtCtgtgtggcaagagatcctta	13	13	1	1	rs150035696	byFrequency	TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:75720637C>G	uc002sni.2	-	4	662	c.184G>C	c.(184-186)GAC>CAC	p.D62H	FAM176A_uc002snj.1_Missense_Mutation_p.D49H|FAM176A_uc002snk.1_Missense_Mutation_p.D62H	NM_001135032	NP_001128504	Q9H8M9	F176A_HUMAN	family with sequence similarity 176, member A	62					apoptosis|autophagy	endoplasmic reticulum membrane|integral to membrane|lysosomal membrane|plasma membrane					0						CGCCTGCAGTCTGTGTGGCAA	0.587													0	0	0	0.010729	0	12	54										G	75720637	C	G	75720637	3	3	74	1	0	0	0	0	1	0	0	0	5499	913	32	1	278	1	FAM176A	2	75720637	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	28331187	75720637	167478736	42	22594										
SEMA4C	54910	broad.mit.edu	37	chr2	97531659	97531659	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcttctccacgggggcctccCaggagatctggggaaaggga	15	11	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:97531659C>A	uc002sxh.3	-	4	426	c.266G>T	c.(265-267)TGG>TTG	p.W89L	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Missense_Mutation_p.W142L	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	89	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						GGGGGCCTCCCAGGAGATCTG	0.597													1	0	7.93312e-07	0.020292	8.41461e-07	11	113										A	97531659	C	A	97531659	3	1	74	1	0	0	0	0	1	0	0	0	14033	595	21	4	2283	4	SEMA4C	2	97531659	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	21811022	97531659	145667714	43	22595										
TMEM87B	84910	broad.mit.edu	37	chr2	112838657	112838657	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctctttctatgattgggcctCatggatatatctctgcatca	7	10	5	1	rs151250123		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:112838657C>T	uc002thm.2	+	7	985	c.616C>T	c.(616-618)CAT>TAT	p.H206Y	TMEM87B_uc010fkg.2_Missense_Mutation_p.H189Y|TMEM87B_uc010fkh.2_3'UTR	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	206						integral to membrane					0						GATTGGGCCTCATGGATATAT	0.333													0	0	0	0.036044	0	25	46										T	112838657	C	T	112838657	3	4	74	1	0	0	0	0	1	0	0	0	16208	826	29	1	642	1	TMEM87B	2	112838657	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	15306998	112838657	130360716	44	22596			1	102		3	3	385	N	G_C	7.498237e-06
TMEM87B	84910	broad.mit.edu	37	chr2	112838676	112838676	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcatggatatatctctgcatCagattggcccctaatgattg	8	9	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:112838676C>G	uc002thm.2	+	7	1004	c.635C>G	c.(634-636)TCA>TGA	p.S212*	TMEM87B_uc010fkg.2_Nonsense_Mutation_p.S195*|TMEM87B_uc010fkh.2_3'UTR	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	212						integral to membrane					0						ATCTCTGCATCAGATTGGCCC	0.328													0	0	0	0.011902	0	27	44										G	112838676	C	G	112838676	4	3	74	1	0	0	0	0	0	1	0	0	16208	838	29	1	661	1	TMEM87B	2	112838676	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	19	112838676	130360697	45	22597			1	102		3	3	385	N	G_C	7.498237e-06
TMEM87B	84910	broad.mit.edu	37	chr2	112839041	112839041	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttatttttttgggaatgcttGaaaaagcagttttttatagt	8	2	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:112839041G>C	uc002thm.2	+	8	1153	c.784G>C	c.(784-786)GAA>CAA	p.E262Q	TMEM87B_uc010fkg.2_Missense_Mutation_p.E245Q|TMEM87B_uc010fkh.2_3'UTR	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	262	Helical; (Potential).					integral to membrane					0						GGGAATGCTTGAAAAAGCAGT	0.358													0	0	0	0.01441	0	44	77										C	112839041	G	C	112839041	3	2	74	1	0	0	0	0	1	0	0	0	16208	1291	45	1	814	1	TMEM87B	2	112839041	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	365	112839041	130360332	46	22598			1	102		3	3	385	N	G_C	7.498237e-06
SCTR	6344	broad.mit.edu	37	chr2	120231035	120231035	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gttgacaggcttacccgcttCtcgttggaagagtcgttcac	11	11	2	2	rs142755533		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:120231035C>G	uc002tma.2	-	4	625	c.399G>C	c.(397-399)GAG>GAC	p.E133D	SCTR_uc002tlz.2_5'UTR	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	133	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	TTACCCGCTTCTCGTTGGAAG	0.592													0	0	0	0.016723	0	12	28										G	120231035	C	G	120231035	3	3	74	1	0	0	0	0	1	0	0	0	13943	912	32	1	963	1	SCTR	2	120231035	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7391994	120231035	122968338	47	22599										
SMPD4	55627	broad.mit.edu	37	chr2	130911366	130911366	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccatctcgtccaggtcgttgGctgtgtaggagccattggtg	14	10	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:130911366G>C	uc002tqq.1	-	17	2439	c.1919C>G	c.(1918-1920)GCC>GGC	p.A640G	SMPD4_uc002tqo.1_Missense_Mutation_p.A172G|SMPD4_uc002tqp.1_Missense_Mutation_p.A379G|SMPD4_uc010yzy.1_Missense_Mutation_p.A389G|SMPD4_uc010yzz.1_Missense_Mutation_p.A304G|SMPD4_uc002tqr.1_Missense_Mutation_p.A611G|SMPD4_uc002tqs.1_Missense_Mutation_p.A508G|SMPD4_uc002tqt.1_Missense_Mutation_p.A489G|SMPD4_uc010zaa.1_Missense_Mutation_p.A498G|SMPD4_uc010zab.1_Missense_Mutation_p.A538G|SMPD4_uc010zac.1_Missense_Mutation_p.A381G|SMPD4_uc010zad.1_Missense_Mutation_p.A276G	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	601					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CAGGTCGTTGGCTGTGTAGGA	0.592													0	0	0	0.01441	0	196	129										C	130911366	G	C	130911366	3	2	74	1	0	0	0	0	1	0	0	0	14807	1203	42	4	697	4	SMPD4	2	130911366	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	10680331	130911366	112288007	48	22600										
LCT	3938	broad.mit.edu	37	chr2	136566130	136566130	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aatggggatgtcaccatactCttccttgatccagttcagca	8	11	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:136566130C>T	uc002tuu.1	-	8	3798	c.3787G>A	c.(3787-3789)GAG>AAG	p.E1263K		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1263	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCACCATACTCTTCCTTGATC	0.537													0	0	0	0.01441	0	85	76										T	136566130	C	T	136566130	3	4	74	1	0	0	0	0	1	0	0	0	8693	922	32	1	2036	1	LCT	2	136566130	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5654764	136566130	106633243	49	22601										
PKP4	8502	broad.mit.edu	37	chr2	159481626	159481626	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccgtactcacagagacccgcCtccccaacagctatacggcg	8	18	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:159481626C>T	uc002tzv.2	+	7	1100	c.840C>T	c.(838-840)GCC>GCT	p.A280A	PKP4_uc002tzt.1_Silent_p.A132A|PKP4_uc002tzu.2_Silent_p.A280A|PKP4_uc002tzw.2_Silent_p.A280A|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Silent_p.A278A|PKP4_uc002uaa.2_Silent_p.A132A	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	280					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						AGAGACCCGCCTCCCCAACAG	0.612										HNSCC(62;0.18)			0	0	0	0.008291	0	10	48										T	159481626	C	T	159481626	2	4	74	1	0	0	0	0	0	0	0	1	11987	668	24	2		2	PKP4	2	159481626	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	22915496	159481626	83717747	50	22602										
HOXD3	3232	broad.mit.edu	37	chr2	177034235	177034235	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	accctgcccccatcttcaccCaccaatcctggaggtggagt	8	17	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:177034235C>A	uc002ukt.1	+	2	569	c.393C>A	c.(391-393)CCC>CCA	p.P131P		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	131					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		catcttcacccACCAATCCTG	0.463													1	0	3.86212e-05	0.008291	4.0267e-05	10	61										A	177034235	C	A	177034235	2	1	74	1	0	0	0	0	0	0	0	1	7323	581	21	4		4	HOXD3	2	177034235	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	17552609	177034235	66165138	51	22603										
PDE11A	50940	broad.mit.edu	37	chr2	178936390	178936390	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aggtgttcctgcatgcacatCaaagaatttggagaccaagg	11	8	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:178936390C>G	uc002ulq.2	-	1	1093	c.775G>C	c.(775-777)GAT>CAT	p.D259H	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	259	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCATGCACATCAAAGAATTTG	0.532									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.020292	0	14	32										G	178936390	C	G	178936390	3	3	74	1	0	0	0	0	1	0	0	0	11631	826	29	1	2106	1	PDE11A	2	178936390	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1902155	178936390	64262983	52	22604										
TTN	7273	broad.mit.edu	37	chr2	179587610	179587610	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttggcattgtaaagaaaccGaatctccaactgctgcctcc	7	13	1	1	rs72648966		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:179587610G>A	uc010zfg.1	-	73	18508	c.18284C>T	c.(18283-18285)TCG>TTG	p.S6095L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2756L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7022							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAAAGAAACCGAATCTCCAAC	0.438													0	0	0	0.02938	0	5	24										A	179587610	G	A	179587610	3	1	74	1	0	0	0	0	1	0	0	0	16732	1059	37	1	82661	1	TTN	2	179587610	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	651220	179587610	63611763	53	22605										
TTN	7273	broad.mit.edu	37	chr2	179605206	179605206	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttgtgcctcttgcttttgaaGagtcactctttgctctctgt	8	10	4	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:179605206G>C	uc010zfh.1	-	46	12465	c.12241C>G	c.(12241-12243)CTT>GTT	p.L4081V	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.L4014V|TTN_uc010zfj.1_Missense_Mutation_p.L3889V|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCTTTTGAAGAGTCACTCTT	0.463													0	0	0	0.004482	0	7	37										C	179605206	G	C	179605206	3	2	74	1	0	0	0	0	1	0	0	0	16732	942	33	1	92035	1	TTN	2	179605206	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	17596	179605206	63594167	54	22606										
BARD1	580	broad.mit.edu	37	chr2	215609878	215609878	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atcaccaggaacaacaacatGagttactaaaatacaaaaaa	4	8	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:215609878G>C	uc002veu.2	-	9	1951	c.1816C>G	c.(1816-1818)CAT>GAT	p.H606D	BARD1_uc010zjm.1_Missense_Mutation_p.H462D	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	606	BRCT 1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACAACAACATGAGTTACTAAA	0.338									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.020292	0	11	36										C	215609878	G	C	215609878	3	2	74	1	0	0	0	0	1	0	0	0	1312	1290	45	1	529	1	BARD1	2	215609878	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	36004672	215609878	27589495	55	22607										
TNS1	7145	broad.mit.edu	37	chr2	218683208	218683208	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cactgttctgtggcgcgcctGagggctcccaggcaccgtgt	14	14	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr2:218683208G>C	uc002vgt.2	-	24	3933	c.3535C>G	c.(3535-3537)CAG>GAG	p.Q1179E	TNS1_uc002vgr.2_Missense_Mutation_p.Q1166E|TNS1_uc002vgs.2_Missense_Mutation_p.Q1158E|TNS1_uc010zjv.1_Missense_Mutation_p.Q1158E	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1179						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGCGCGCCTGAGGGCTCCCA	0.637													0	0	0	0.016723	0	11	79										C	218683208	G	C	218683208	3	2	74	1	0	0	0	0	1	0	0	0	16340	1299	45	1	1712	1	TNS1	2	218683208	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3073330	218683208	24516165	56	22608										
C3orf32	51066	broad.mit.edu	37	chr3	8667307	8667307	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggcagttgagccggtgctcaGacacaaactcaaacaagctg	11	11	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:8667307G>T	uc003bqu.2	-	10	974	c.728C>A	c.(727-729)TCT>TAT	p.S243Y	C3orf32_uc003bqz.2_Missense_Mutation_p.S243Y|C3orf32_uc003bqt.2_Missense_Mutation_p.S192Y|C3orf32_uc011atg.1_Missense_Mutation_p.S265Y|C3orf32_uc003bqv.2_Missense_Mutation_p.S192Y|C3orf32_uc003bqw.2_RNA|C3orf32_uc003bqx.2_RNA|C3orf32_uc003bqy.2_Missense_Mutation_p.S243Y	NM_015931	NP_057015	Q9Y2M2	CC032_HUMAN	hypothetical protein LOC51066	243										skin(1)	1						CCGGTGCTCAGACACAAACTC	0.398													1	0	1.99824e-07	0.0333	2.13805e-07	14	92										T	8667307	G	T	8667307	3	4	74	1	0	0	0	0	1	0	0	0	2222	942	33	3	345	3	C3orf32	3	8667307	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		8667307	189355123	57	22609										
FANCD2	2177	broad.mit.edu	37	chr3	10094121	10094121	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctcagcaaatacgaaaactCttctatgttctcagcacact	4	13	4	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:10094121C>G	uc003buw.2	+	18	1674	c.1596C>G	c.(1594-1596)CTC>CTG	p.L532L	FANCD2_uc003bux.1_Silent_p.L532L|FANCD2_uc003buy.1_Silent_p.L532L|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	532					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TACGAAAACTCTTCTATGTTC	0.388			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.0333	0	13	120										G	10094121	C	G	10094121	2	3	74	1	0	0	0	0	0	0	0	1	5665	900	32	1		1	FANCD2	3	10094121	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1426814	10094121	187928309	58	22610										
NGLY1	55768	broad.mit.edu	37	chr3	25775404	25775404	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agtgtctcgaagtaatgcttCtttaaccttagttcttctgg	8	8	4	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:25775404C>T	uc003cdl.2	-	8	1327	c.1219G>A	c.(1219-1221)GAA>AAA	p.E407K	NGLY1_uc010hfg.2_Missense_Mutation_p.E389K|NGLY1_uc003cdm.2_Missense_Mutation_p.E407K|NGLY1_uc011awo.1_Missense_Mutation_p.E365K|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	407					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						AGTAATGCTTCTTTAACCTTA	0.343													0	0	0	0.016723	0	11	112										T	25775404	C	T	25775404	3	4	74	1	0	0	0	0	1	0	0	0	10398	922	32	1	765	1	NGLY1	3	25775404	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	15681283	25775404	172247026	59	22611										
MLH1	4292	broad.mit.edu	37	chr3	37056000	37056000	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	catatccaatgcaaactactCagtgaagaagtgcatcttct	6	10	3	2	rs121912956		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:37056000C>G	uc003cgl.2	+	9	815	c.755C>G	c.(754-756)TCA>TGA	p.S252*	MLH1_uc011aye.1_Nonsense_Mutation_p.S11*|MLH1_uc011ayb.1_Nonsense_Mutation_p.S11*|MLH1_uc010hge.2_Nonsense_Mutation_p.S252*|MLH1_uc003cgn.3_Nonsense_Mutation_p.S11*|MLH1_uc011ayc.1_Nonsense_Mutation_p.S154*|MLH1_uc011ayd.1_Nonsense_Mutation_p.S11*|MLH1_uc003cgo.2_Nonsense_Mutation_p.S11*|MLH1_uc010hgg.1_5'UTR|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_5'UTR|MLH1_uc010hgl.1_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	252			Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.S252*(2)|p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						GCAAACTACTCAGTGAAGAAG	0.378		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.00308	0	6	70										G	37056000	C	G	37056000	4	3	74	1	0	0	0	0	0	1	0	0	9617	838	29	1	789	1	MLH1	3	37056000	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	11280596	37056000	160966430	60	22612										
ANO10	55129	broad.mit.edu	37	chr3	43640099	43640099	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atctttagctctaagattttCaagttcatgtttgataatga	6	5	4	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:43640099C>G	uc003cmv.2	-	4	568	c.397G>C	c.(397-399)GAA>CAA	p.E133Q	ANO10_uc011azs.1_Missense_Mutation_p.E133Q|ANO10_uc003cmw.2_Missense_Mutation_p.E67Q|ANO10_uc010hil.2_Missense_Mutation_p.E133Q|ANO10_uc011azt.1_Intron	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	133	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						CTAAGATTTTCAAGTTCATGT	0.313													0	0	0	0.004672	0	3	42										G	43640099	C	G	43640099	3	3	74	1	0	0	0	0	1	0	0	0	696	835	29	1	1625	1	ANO10	3	43640099	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6584099	43640099	154382331	61	22613										
DALRD3	55152	broad.mit.edu	37	chr3	49055271	49055271	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaaggtcagcatgtgcggatCccgcacagctggcactaggc	14	12	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:49055271C>T	uc003cvk.1	-	3	513	c.493G>A	c.(493-495)GAT>AAT	p.D165N	DALRD3_uc003cvl.1_Missense_Mutation_p.D165N|DALRD3_uc003cvm.1_5'UTR|DALRD3_uc010hko.1_5'UTR|DALRD3_uc011bca.1_Missense_Mutation_p.D165N|NDUFAF3_uc003cvn.2_5'Flank	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	165					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATGTGCGGATCCCGCACAGCT	0.672													0	0	0	0.021553	0	5	20										T	49055271	C	T	49055271	3	4	74	1	0	0	0	0	1	0	0	0	4229	855	30	1	1178	1	DALRD3	3	49055271	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5415172	49055271	148967159	62	22614										
GNAT1	2779	broad.mit.edu	37	chr3	50231304	50231304	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgcagttctccttcaaggatCtcaacttccggtacgaccca	7	15	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:50231304C>T	uc003cym.2	+	5	684	c.568C>T	c.(568-570)CTC>TTC	p.L190F	GNAT1_uc003cyl.2_Missense_Mutation_p.L190F	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	190					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CTTCAAGGATCTCAACTTCCG	0.657													0	0	0	0.025465	0	30	72										T	50231304	C	T	50231304	3	4	74	1	0	0	0	0	1	0	0	0	6511	913	32	1	586	1	GNAT1	3	50231304	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1176033	50231304	147791126	63	22615										
ALAS1	211	broad.mit.edu	37	chr3	52233298	52233298	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgcccattcttatcccgagTcccccaggcctttctgcaga	7	17	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:52233298T>G	uc003dcy.1	+	3	378	c.41T>G	c.(40-42)GTC>GGC	p.V14G	ALAS1_uc003dcx.1_Missense_Mutation_p.V14G|ALAS1_uc003dcz.1_Missense_Mutation_p.V14G|ALAS1_uc011bec.1_Missense_Mutation_p.V31G	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	14					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTATCCCGAGTCCCCCAGGCC	0.527													0	0	0	0.008871	0	14	73										G	52233298	T	G	52233298	3	3	74	1	0	0	0	0	1	0	0	0	484	1667	58	5	43	5	ALAS1	3	52233298	Missense_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	2001994	52233298	145789132	64	22616										
ADAMTS9	56999	broad.mit.edu	37	chr3	64617494	64617494	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agattcttaccataatgtacTgtattaaatgttcctgccac	5	9	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:64617494T>C	uc003dmg.2	-	15	2315	c.2283A>G	c.(2281-2283)ACA>ACG	p.T761T	ADAMTS9_uc011bfo.1_Silent_p.T733T|ADAMTS9_uc003dmh.1_Silent_p.T590T|ADAMTS9_uc003dmk.1_Silent_p.T761T	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	761	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CATAATGTACTGTATTAAATG	0.358													0	0	0	0.010504	0	18	86										C	64617494	T	C	64617494	2	2	74	1	0	0	0	0	0	0	0	1	273	1567	55	5		5	ADAMTS9	3	64617494	Silent	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	12384196	64617494	133404936	65	22617										
CBLB	868	broad.mit.edu	37	chr3	105377939	105377939	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcttcaaaggcataaccctCtcccatgagttttgcaattt	5	12	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:105377939C>G	uc003dwc.2	-	19	3146	c.2824G>C	c.(2824-2826)GAG>CAG	p.E942Q	CBLB_uc003dwa.2_Missense_Mutation_p.E157Q|CBLB_uc011bhi.1_Missense_Mutation_p.E920Q	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	942	UBA.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						GCATAACCCTCTCCCATGAGT	0.512			Mis S		AML								0	0	0	0.028581	0	13	122										G	105377939	C	G	105377939	3	3	74	1	0	0	0	0	1	0	0	0	2701	922	32	1	128	1	CBLB	3	105377939	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	40760445	105377939	92644491	66	22618										
C3orf1	51300	broad.mit.edu	37	chr3	119222468	119222468	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtgtttgtgactatattcaaGtaagttcactctgaattgtg	9	5	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:119222468G>A	uc003ecn.2	+	3	662	c.449_splice	c.e3+1	p.N150_splice	C3orf1_uc003eco.2_Splice_Site|C3orf1_uc003ecp.2_Splice_Site	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300							integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		CTATATTCAAGTAAGTTCACT	0.418													0	0	0	0.004482	0	7	11										A	119222468	G	A	119222468	5	1	74	1	0	0	0	0	0	0	1	0	2206	1043	36	2	460	2	C3orf1	3	119222468	Splice_Site	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	13844529	119222468	78799962	67	22619										
PARP14	54625	broad.mit.edu	37	chr3	122437553	122437553	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aggcgatgatcaagagagttCgattggccaaagaacaggaa	13	6	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:122437553C>T	uc003efq.3	+	14	4614	c.4555C>T	c.(4555-4557)CGA>TGA	p.R1519*	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Nonsense_Mutation_p.R1236*|PARP14_uc003efs.1_Nonsense_Mutation_p.R1236*	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CAAGAGAGTTCGATTGGCCAA	0.398													0	0	0	0.01441	0	49	263										T	122437553	C	T	122437553	4	4	74	1	0	0	0	0	0	1	0	0	11458	876	31	1	4609	1	PARP14	3	122437553	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3215085	122437553	75584877	68	22620										
RASA2	5922	broad.mit.edu	37	chr3	141326559	141326559	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aatcccagtaaaaaacattcTtgctgtggaaaaactggaag	8	7	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:141326559T>A	uc003etz.1	+	20	1973	c.1973T>A	c.(1972-1974)CTT>CAT	p.L658H	RASA2_uc010huq.1_Missense_Mutation_p.L662H|RASA2_uc003eua.1_Missense_Mutation_p.L659H	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	658	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						AAAAACATTCTTGCTGTGGAA	0.264													0	0	0	0.010729	0	8	46										A	141326559	T	A	141326559	3	1	74	1	0	0	0	0	1	0	0	0	13061	1609	56	5	2051	5	RASA2	3	141326559	Missense_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	18889006	141326559	56695871	69	22621										
SERPINI2	5276	broad.mit.edu	37	chr3	167183420	167183420	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caccaggacaagccgagtcaGagggccaaattcttcccctg	10	14	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:167183420G>C	uc003fer.1	-	3	578	c.520C>G	c.(520-522)CTG>GTG	p.L174V	SERPINI2_uc003fes.1_Missense_Mutation_p.L184V|SERPINI2_uc003fet.1_Missense_Mutation_p.L174V	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	174					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						AGCCGAGTCAGAGGGCCAAAT	0.383													0	0	0	0.007413	0	14	37										C	167183420	G	C	167183420	3	2	74	1	0	0	0	0	1	0	0	0	14119	933	33	1	721	1	SERPINI2	3	167183420	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	25856861	167183420	30839010	70	22622										
LRRC31	79782	broad.mit.edu	37	chr3	169572606	169572606	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcaatatatacttactcagtGacatcacgtcatctgctgtt	6	10	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:169572606G>T	uc003fgc.1	-	6	1063	c.986C>A	c.(985-987)TCA>TAA	p.S329*	LRRC31_uc010hwp.1_Nonsense_Mutation_p.S273*	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	329	LRR 4.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CTTACTCAGTGACATCACGTC	0.398													1	0	4.15321e-07	0.009535	4.4309e-07	24	98										T	169572606	G	T	169572606	4	4	74	1	0	0	0	0	0	1	0	0	8986	1294	45	3	688	3	LRRC31	3	169572606	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2389186	169572606	28449824	71	22623										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:178936091G>C	uc003fjk.2	+	10	1790	c.1633G>C	c.(1633-1635)GAG>CAG	p.E545Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.010504	0	17	58										C	178936091	G	C	178936091	3	2	74	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	9363485	178936091	19086339	72	22624										
EPHB3	2049	broad.mit.edu	37	chr3	184298213	184298213	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aacgatgggcagttcacggtCatccagctggtgggcatgtt	14	9	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr3:184298213C>T	uc003foz.2	+	12	2633	c.2196C>T	c.(2194-2196)GTC>GTT	p.V732V		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	732	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGTTCACGGTCATCCAGCTGG	0.612													0	0	0	0.030593	0	23	176										T	184298213	C	T	184298213	2	4	74	1	0	0	0	0	0	0	0	1	5176	813	29	1		1	EPHB3	3	184298213	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5362122	184298213	13724217	73	22625										
FAM13A	10144	broad.mit.edu	37	chr4	89660243	89660243	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cagccggtacctgtcgtataGtggcttcatcacctgccgtt	10	13	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:89660243G>A	uc003hse.1	-	20	2708	c.2500C>T	c.(2500-2502)CTA>TTA	p.L834L	FAM13A_uc011cdp.1_5'Flank|FAM13A_uc003hsa.1_Silent_p.L305L|FAM13A_uc003hsb.1_Silent_p.L508L|FAM13A_uc003hsd.1_Silent_p.L508L|FAM13A_uc003hsc.1_Silent_p.L494L|FAM13A_uc011cdq.1_Silent_p.L480L|FAM13A_uc003hsf.1_Silent_p.L420L|FAM13A_uc003hsg.1_Silent_p.L305L	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	834					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						CTGTCGTATAGTGGCTTCATC	0.498													0	0	0	0.012213	0	23	62										A	89660243	G	A	89660243	2	1	74	1	0	0	0	0	0	0	0	1	5452	1020	36	2		2	FAM13A	4	89660243	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		89660243	101494033	74	22626										
TMSL3	7117	broad.mit.edu	37	chr4	91760120	91760120	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggcagtggatttttctcttgCgtctctgtcttcttcagttt	9	9	5	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:91760120C>T	uc003hsy.2	-	1	150	c.69G>A	c.(67-69)ACG>ACA	p.T23T	FAM190A_uc003hsv.3_Intron|FAM190A_uc010ikv.2_Intron|FAM190A_uc003hsx.2_Intron	NM_183049	NP_898870			thymosin-like 3												0		all_cancers(2;6.48e-24)|all_epithelial(2;3.86e-25)|Colorectal(2;8.52e-12)|all_lung(2;3.73e-07)|Lung NSC(2;7.99e-07)|Renal(2;0.0243)|Hepatocellular(203;0.0411)		Epithelial(2;5.28e-11)|OV - Ovarian serous cystadenocarcinoma(123;8.9e-10)|all cancers(2;3.21e-09)|STAD - Stomach adenocarcinoma(1;0.0201)		TTTTCTCTTGCGTCTCTGTCT	0.507													0	0	0	0.006214	0	9	127										T	91760120	C	T	91760120	2	4	74	1	0	0	0	0	0	0	0	1	16256	755	27	2		2	TMSL3	4	91760120	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2099877	91760120	99394156	75	22627										
C4orf21	55345	broad.mit.edu	37	chr4	113508784	113508784	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgatatttcagccacttgctCtgagtagatatattattaag	7	6	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:113508784C>G	uc003iau.2	-	12	3640	c.3429G>C	c.(3427-3429)CAG>CAC	p.Q1143H	C4orf21_uc003iav.2_RNA	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GCCACTTGCTCTGAGTAGATA	0.403													0	0	0	0.010729	0	12	41										G	113508784	C	G	113508784	3	3	74	1	0	0	0	0	1	0	0	0	2254	912	32	1	2953	1	C4orf21	4	113508784	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	21748664	113508784	77645492	76	22628										
ANK2	287	broad.mit.edu	37	chr4	114275328	114275328	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tatcaccatcaagtaaaactGagaaacactcacctgtgtca	5	11	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:114275328G>T	uc003ibe.3	+	38	5654	c.5554G>T	c.(5554-5556)GAG>TAG	p.E1852*	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Nonsense_Mutation_p.E1867*	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1819	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGTAAAACTGAGAAACACTC	0.478													1	0	3.40343e-31	0.01441	3.92785e-31	46	137										T	114275328	G	T	114275328	4	4	74	1	0	0	0	0	0	1	0	0	621	1291	45	3	5769	3	ANK2	4	114275328	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	766544	114275328	76878948	77	22629										
ANK2	287	broad.mit.edu	37	chr4	114275400	114275400	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgtcatcatcgagtaaaactGagaaacactcacctgtatca	6	11	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:114275400G>A	uc003ibe.3	+	38	5726	c.5626G>A	c.(5626-5628)GAG>AAG	p.E1876K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.E1891K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1843	Repeat A.|Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGTAAAACTGAGAAACACTC	0.458													0	0	0	0.01441	0	43	128										A	114275400	G	A	114275400	3	1	74	1	0	0	0	0	1	0	0	0	621	1291	45	1	5841	1	ANK2	4	114275400	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	72	114275400	76878876	78	22630										
EXOSC9	5393	broad.mit.edu	37	chr4	122735121	122735121	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	actctgagaaggaagatgatGaaggcggtggtgatcaagct	15	5	2	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:122735121G>A	uc003iea.2	+	10	1183	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	EXOSC9_uc003idz.2_Missense_Mutation_p.E359K|EXOSC9_uc003ieb.2_Missense_Mutation_p.E343K|EXOSC9_uc010inp.1_RNA	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	359					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						GGAAGATGATGAAGGCGGTGG	0.453													0	0	0	0.017118	0	32	87										A	122735121	G	A	122735121	3	1	74	1	0	0	0	0	1	0	0	0	5321	1291	45	1	1113	1	EXOSC9	4	122735121	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	8459721	122735121	68419155	79	22631										
BBS7	55212	broad.mit.edu	37	chr4	122766713	122766713	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tctaagataaggctgtaactGgcatcatctttatttagtgt	8	6	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:122766713G>A	uc003ied.2	-	11	1350	c.1176C>T	c.(1174-1176)GCC>GCT	p.A392A	BBS7_uc003iee.1_Silent_p.A392A	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	392					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						GGCTGTAACTGGCATCATCTT	0.313									Bardet-Biedl_syndrome				0	0	0	0.020292	0	12	44										A	122766713	G	A	122766713	2	1	74	1	0	0	0	0	0	0	0	1	1341	1335	47	2		2	BBS7	4	122766713	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	31592	122766713	68387563	80	22632										
C4orf51	646603	broad.mit.edu	37	chr4	146653608	146653608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aggccatttttctccagcttCatggacggtgcgattctgaa	10	10	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:146653608C>T	uc003ikk.2	+	6	505	c.505C>T	c.(505-507)CAT>TAT	p.H169Y		NM_001080531	NP_001074000	C9J302	CD051_HUMAN	chromosome 4 open reading frame 51	169											0						TCTCCAGCTTCATGGACGGTG	0.473													0	0	0	0.02938	0	6	23										T	146653608	C	T	146653608	3	4	74	1	0	0	0	0	1	0	0	0	2277	826	29	1	527	1	C4orf51	4	146653608	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	23886895	146653608	44500668	81	22633										
DCLK2	166614	broad.mit.edu	37	chr4	151124998	151124998	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcctaaatctacgaaatcctCcagttcctctccaactagtc	3	15	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:151124998C>G	uc003ilm.3	+	5	1113	c.1013C>G	c.(1012-1014)TCC>TGC	p.S338C	DCLK2_uc003iln.3_Missense_Mutation_p.S338C|DCLK2_uc003ilo.3_Missense_Mutation_p.S355C|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	338	Ser-rich.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					ACGAAATCCTCCAGTTCCTCT	0.393													0	0	0	0.012319	0	18	109										G	151124998	C	G	151124998	3	3	74	1	0	0	0	0	1	0	0	0	4292	855	30	1	1031	1	DCLK2	4	151124998	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4471390	151124998	40029278	82	22634										
FHDC1	85462	broad.mit.edu	37	chr4	153893636	153893636	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gacaaaaaaaccatgaaactGgatgaatgctttcagatatt	7	6	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:153893636G>A	uc003inf.2	+	10	1401	c.1326G>A	c.(1324-1326)CTG>CTA	p.L442L		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	442	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					CCATGAAACTGGATGAATGCT	0.393													0	0	0	0.010504	0	19	81										A	153893636	G	A	153893636	2	1	74	1	0	0	0	0	0	0	0	1	5876	1335	47	2		2	FHDC1	4	153893636	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2768638	153893636	37260640	83	22635										
GUCY1A3	2982	broad.mit.edu	37	chr4	156638380	156638380	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agagtgatactcatgctgttCagatagcgctgatggccctg	12	9	2	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr4:156638380C>T	uc003iov.2	+	9	2178	c.1642C>T	c.(1642-1644)CAG>TAG	p.Q548*	GUCY1A3_uc010iqc.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc003iow.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc010iqd.2_Nonsense_Mutation_p.Q547*|GUCY1A3_uc003iox.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc003ioz.2_Nonsense_Mutation_p.Q313*|GUCY1A3_uc003ioy.2_Nonsense_Mutation_p.Q548*|GUCY1A3_uc010iqe.2_Nonsense_Mutation_p.Q313*|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Nonsense_Mutation_p.Q548*	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	548	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TCATGCTGTTCAGATAGCGCT	0.423													0	0	0	0.0333	0	14	54										T	156638380	C	T	156638380	4	4	74	1	0	0	0	0	0	1	0	0	6894	827	29	1	1679	1	GUCY1A3	4	156638380	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2744744	156638380	34515896	84	22636										
EXOC3	11336	broad.mit.edu	37	chr5	453801	453801	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aaaattgacaggcgcatactTgaccggaaaaagcaaactgg	10	8	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:453801T>A	uc003jba.2	+	4	809	c.681T>A	c.(679-681)CTT>CTA	p.L227L		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	238					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GGCGCATACTTGACCGGAAAA	0.507													0	0	0	0.01892	0	21	91										A	453801	T	A	453801	2	1	74	1	0	0	0	0	0	0	0	1	5303	1799	63	5		5	EXOC3	5	453801	Silent	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08		453801	180461459	85	22637										
ADCY2	108	broad.mit.edu	37	chr5	7773096	7773096	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tatcctgttccgtgttcctgCgggtaaactatgagctgaag	11	9	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:7773096C>T	uc003jdz.1	+	18	2333	c.2266C>T	c.(2266-2268)CGG>TGG	p.R756W	ADCY2_uc011cmo.1_Missense_Mutation_p.R576W	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	756					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGTGTTCCTGCGGGTAAACTA	0.502													0	0	0	0.037714	0	26	126										T	7773096	C	T	7773096	3	4	74	1	0	0	0	0	1	0	0	0	294	759	27	2	2336	2	ADCY2	5	7773096	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7319295	7773096	173142164	86	22638										
SEMA5A	9037	broad.mit.edu	37	chr5	9197325	9197325	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tacggtagccaggccgagcgCgagttttcttggtacttgaa	13	9	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:9197325C>T	uc003jek.2	-	10	1735	c.1023G>A	c.(1021-1023)TCG>TCA	p.S341S		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	341	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AGGCCGAGCGCGAGTTTTCTT	0.592													0	0	0	0.007413	0	18	64										T	9197325	C	T	9197325	2	4	74	1	0	0	0	0	0	0	0	1	14037	755	27	2		2	SEMA5A	5	9197325	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1424229	9197325	171717935	87	22639										
TRIO	7204	broad.mit.edu	37	chr5	14387596	14387596	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acagctggctgatggcttttGtgaaaaagggcatgcccatg	13	8	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:14387596G>C	uc003jff.2	+	22	3626	c.3620G>C	c.(3619-3621)TGT>TCT	p.C1207S	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.C1158S|TRIO_uc003jfh.1_Missense_Mutation_p.C856S	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1207	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GATGGCTTTTGTGAAAAAGGG	0.448													0	0	0	0.014323	0	19	73										C	14387596	G	C	14387596	3	2	74	1	0	0	0	0	1	0	0	0	16549	1377	48	4	3706	4	TRIO	5	14387596	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5190271	14387596	166527664	88	22640										
ITGA2	3673	broad.mit.edu	37	chr5	52377489	52377489	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acaaacatcttcttctgtatCtttcaaaagtgaaaatttca	3	8	6	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:52377489C>T	uc003joy.2	+	26	3250	c.3107C>T	c.(3106-3108)TCT>TTT	p.S1036F	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.S960F|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	1036	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TCTTCTGTATCTTTCAAAAGT	0.398													0	0	0	0.00308	0	6	20										T	52377489	C	T	52377489	3	4	74	1	0	0	0	0	1	0	0	0	7875	913	32	1	3209	1	ITGA2	5	52377489	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	37989893	52377489	128537771	89	22641										
MAP1B	4131	broad.mit.edu	37	chr5	71490041	71490041	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcaatatgctcatcaatggcGgatcagagagaaaatcctgc	9	9	4	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:71490041G>A	uc003kbw.3	+	5	1100	c.859G>A	c.(859-861)GGA>AGA	p.G287R	MAP1B_uc010iyw.1_Missense_Mutation_p.G304R|MAP1B_uc010iyx.1_Missense_Mutation_p.G161R|MAP1B_uc010iyy.1_Missense_Mutation_p.G161R	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	287						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CATCAATGGCGGATCAGAGAG	0.483													0	0	0	0.0333	0	17	95										A	71490041	G	A	71490041	3	1	74	1	0	0	0	0	1	0	0	0	9228	1117	39	2	877	2	MAP1B	5	71490041	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	19112552	71490041	109425219	90	22642										
ANKRD34B	340120	broad.mit.edu	37	chr5	79854455	79854455	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttgttgttgacattgatatCtgagatgggagggtgagaat	14	3	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:79854455C>A	uc010jam.2	-	4	1734	c.1384G>T	c.(1384-1386)GAT>TAT	p.D462Y	ANKRD34B_uc003kgw.2_Missense_Mutation_p.D462Y|ANKRD34B_uc010jan.2_Missense_Mutation_p.D462Y	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	462						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		ACATTGATATCTGAGATGGGA	0.413													1	0	6.97489e-18	0.021022	7.8521e-18	31	160										A	79854455	C	A	79854455	3	1	74	1	0	0	0	0	1	0	0	0	663	913	32	3	164	3	ANKRD34B	5	79854455	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	8364414	79854455	101060805	91	22643										
YTHDC2	64848	broad.mit.edu	37	chr5	112915339	112915339	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tggaggacaaaactacagctAatttggcagccttgaaactt	9	8	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:112915339A>G	uc003kqn.2	+	24	3484	c.3301A>G	c.(3301-3303)AAT>GAT	p.N1101D		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1101							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AACTACAGCTAATTTGGCAGC	0.373													0	0	0	0.01441	0	61	138										G	112915339	A	G	112915339	3	3	74	1	0	0	0	0	1	0	0	0	17494	362	13	5	3395	5	YTHDC2	5	112915339	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	33060884	112915339	67999921	92	22644										
PAIP2	51247	broad.mit.edu	37	chr5	138700267	138700267	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atctagatagaagaggagttAtgggaagaagaatttattga	12	1	1	6			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:138700267A>T	uc003led.2	+	3	330	c.153A>T	c.(151-153)TTA>TTT	p.L51F	PAIP2_uc003lee.2_Missense_Mutation_p.L51F|PAIP2_uc003lef.2_Missense_Mutation_p.L51F	NM_016480	NP_057564	Q9BPZ3	PAIP2_HUMAN	poly(A) binding protein interacting protein 2	51	Glu-rich.|PABPC1-interacting motif-1 (PAM1).				negative regulation of translational initiation	cytoplasm	protein binding|translation repressor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAGAGGAGTTATGGGAAGAAG	0.348													0	0	0	0.008291	0	7	49										T	138700267	A	T	138700267	3	4	74	1	0	0	0	0	1	0	0	0	11397	446	16	5	159	5	PAIP2	5	138700267	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	25784928	138700267	42214993	93	22645										
PCDHA8	56140	broad.mit.edu	37	chr5	140222772	140222772	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agcagccctcgcatcccgttCcgcgtggggctgtacacggg	14	15	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:140222772C>T	uc003lhs.2	+	1	1866	c.1866C>T	c.(1864-1866)TTC>TTT	p.F622F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.F622F	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	622	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATCCCGTTCCGCGTGGGGC	0.647													0	0	0	0.01441	0	49	109										T	140222772	C	T	140222772	2	4	74	1	0	0	0	0	0	0	0	1	11530	854	30	1		1	PCDHA8	5	140222772	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1522505	140222772	40692488	94	22646										
PCDHA11	56138	broad.mit.edu	37	chr5	140249748	140249748	+	Frame_Shift_Del	DEL	T	T	-													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgaagtcgccgtgacttccTtgtccctcccagtacgagag							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:140249748delT	uc003lia.2	+	1	1918	c.1060delT	c.(1060-1062)TTGfs	p.L354fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Frame_Shift_Del_p.L354fs	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	354	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGACTTCCTTGTCCCTCCC	0.572																		43	66	---	---								-	140249748	T	-	140249748	7	5	74	1	0	1	0	1	0	0	0	0	11521	1606	56	0	1062	0	PCDHA11	5	140249748	Frame_Shift_Del	DEL	T	TCGA-FD-A3B6-01A-21D-A20D-08	26976	140249748	40665512	95	22647										
PCDHB14	56122	broad.mit.edu	37	chr5	140603436	140603436	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tttacagttttttcggtttgAgctgtgtgtcaaagacataa	9	5	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:140603436A>G	uc003ljb.2	+	1	359	c.359A>G	c.(358-360)GAG>GGG	p.E120G	PCDHB14_uc011dal.1_Intron	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	120	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCGGTTTGAGCTGTGTGTC	0.423													0	0	0	0.009535	0	24	85										G	140603436	A	G	140603436	3	3	74	1	0	0	0	0	1	0	0	0	11539	304	11	5	361	5	PCDHB14	5	140603436	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	353688	140603436	40311824	96	22648										
POU4F3	5459	broad.mit.edu	37	chr5	145719138	145719138	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtaatatatttggaagctttGatgagagcctgctggcacgc	12	7	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:145719138G>C	uc003loa.2	+	2	237	c.148G>C	c.(148-150)GAT>CAT	p.D50H		NM_002700	NP_002691	Q15319	PO4F3_HUMAN	POU class 4 homeobox 3	50					sensory perception of sound|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGAAGCTTTGATGAGAGCCT	0.537													0	0	0	0.017118	0	31	46										C	145719138	G	C	145719138	3	2	74	1	0	0	0	0	1	0	0	0	12280	1290	45	1	154	1	POU4F3	5	145719138	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5115702	145719138	35196122	97	22649										
KIF4B	285643	broad.mit.edu	37	chr5	154395261	154395261	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caaatagctgatctgaagaaGaaactgaatgagcagtccaa	9	7	1	6			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:154395261G>A	uc010jih.1	+	1	2002	c.1842G>A	c.(1840-1842)AAG>AAA	p.K614K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	614	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATCTGAAGAAGAAACTGAATG	0.463													0	0	0	0.019004	0	29	54										A	154395261	G	A	154395261	2	1	74	1	0	0	0	0	0	0	0	1	8304	933	33	1		1	KIF4B	5	154395261	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	8676123	154395261	26519999	98	22650										
ITK	3702	broad.mit.edu	37	chr5	156679642	156679642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agaagatcggccagccttctCcagactgctgcgtcaactgg	11	13	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr5:156679642C>T	uc003lwo.1	+	17	1899	c.1817C>T	c.(1816-1818)TCC>TTC	p.S606F		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	606	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCAGCCTTCTCCAGACTGCTG	0.468			T	SYK	peripheral T-cell lymphoma								0	0	0	0.01441	0	37	67										T	156679642	C	T	156679642	3	4	74	1	0	0	0	0	1	0	0	0	7909	855	30	1	1883	1	ITK	5	156679642	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2284381	156679642	24235618	99	22651										
TFAP2A	7020	broad.mit.edu	37	chr6	10404842	10404842	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttgtacttcgaggtggagctGaggagcgagaggcgacccgg	18	8	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:10404842G>A	uc003myr.2	-	4	915	c.663C>T	c.(661-663)CTC>CTT	p.L221L	TFAP2A_uc003myq.2_Silent_p.L215L|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Silent_p.L221L|TFAP2A_uc003myt.2_Silent_p.L217L|TFAP2A_uc003myu.1_Silent_p.L221L	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	221					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGTGGAGCTGAGGAGCGAGA	0.622													0	0	0	0.0333	0	14	29										A	10404842	G	A	10404842	2	1	74	1	0	0	0	0	0	0	0	1	15784	1277	45	1		1	TFAP2A	6	10404842	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		10404842	160710225	100	22652										
HSPA1L	3305	broad.mit.edu	37	chr6	31777967	31777967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caattcctttctcttatgatCaaactcatctttctctgcca	2	13	5	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:31777967C>T	uc003nxh.2	-	2	1966	c.1783G>A	c.(1783-1785)GAT>AAT	p.D595N	HSPA1L_uc010jte.2_Missense_Mutation_p.D595N	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	595					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						CTCTTATGATCAAACTCATCT	0.448													0	0	0	0.030466	0	32	97										T	31777967	C	T	31777967	3	4	74	1	0	0	0	0	1	0	0	0	7410	826	29	1	146	1	HSPA1L	6	31777967	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	21373125	31777967	139337100	101	22653										
GPSM3	63940	broad.mit.edu	37	chr6	32159216	32159216	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctgaactctcagcagcaacTccaggagctcttgcccccct	7	18	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:32159216T>C	uc003oay.3	-	4	803	c.410A>G	c.(409-411)GAG>GGG	p.E137G	PBX2_uc003oav.1_5'Flank|PBX2_uc003oaw.2_5'Flank|GPSM3_uc003oax.3_Missense_Mutation_p.E114G|GPSM3_uc003oaz.2_Missense_Mutation_p.E137G	NM_022107	NP_071390	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3 (AGS3-like, C.	137	GoLoco 3.				signal transduction	cytoplasm	GTPase activator activity|protein binding				0						CAGCAGCAACTCCAGGAGCTC	0.642													0	0	0	0.010818	0	31	51										C	32159216	T	C	32159216	3	2	74	1	0	0	0	0	1	0	0	0	6736	1551	54	5	76	5	GPSM3	6	32159216	Missense_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	381249	32159216	138955851	102	22654										
COL21A1	81578	broad.mit.edu	37	chr6	56006588	56006588	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tttgtgtgtgtttaccttgtCaccatctcgccctggttctc	8	12	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:56006588C>G	uc003pcs.2	-	12	1769	c.1537G>C	c.(1537-1539)GAC>CAC	p.D513H	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.D513H|COL21A1_uc003pcu.1_Missense_Mutation_p.D510H	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	513					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTTACCTTGTCACCATCTCGC	0.388													0	0	0	0.01892	0	19	59										G	56006588	C	G	56006588	3	3	74	1	0	0	0	0	1	0	0	0	3680	826	29	1	1412	1	COL21A1	6	56006588	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	23847372	56006588	115108479	103	22655										
ZNF292	23036	broad.mit.edu	37	chr6	87971379	87971379	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acaagaatcttaaagattgcActgagcttgtcttaaagcaa	7	7	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:87971379A>G	uc003plm.3	+	8	8073	c.8032A>G	c.(8032-8034)ACT>GCT	p.T2678A		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2678					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAAAGATTGCACTGAGCTTGT	0.348													0	0	0	0.02938	0	7	16										G	87971379	A	G	87971379	3	3	74	1	0	0	0	0	1	0	0	0	17823	159	6	5	8062	5	ZNF292	6	87971379	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	31964791	87971379	83143688	104	22656										
AIM1	202	broad.mit.edu	37	chr6	106975304	106975304	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggcacgaagaagcagagtctGataagccagtggtgattggt	15	6	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:106975304G>C	uc003prh.2	+	5	3800	c.3313G>C	c.(3313-3315)GAT>CAT	p.D1105H		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1105	Beta/gamma crystallin 'Greek key' 2.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGCAGAGTCTGATAAGCCAGT	0.403													0	0	0	0.01441	0	52	258										C	106975304	G	C	106975304	3	2	74	1	0	0	0	0	1	0	0	0	430	1290	45	1	3331	1	AIM1	6	106975304	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	19003925	106975304	64139763	105	22657										
LAMA2	3908	broad.mit.edu	37	chr6	129573422	129573422	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acaaatcacatacagctttgGgatggatgccatcttcaggt	9	9	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:129573422G>A	uc003qbn.2	+	14	2183	c.2078G>A	c.(2077-2079)GGG>GAG	p.G693E	LAMA2_uc003qbo.2_Missense_Mutation_p.G693E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	693	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TACAGCTTTGGGATGGATGCC	0.448													0	0	0	0.00308	0	7	62										A	129573422	G	A	129573422	3	1	74	1	0	0	0	0	1	0	0	0	8606	1232	43	2	2132	2	LAMA2	6	129573422	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	22598118	129573422	41541645	106	22658										
EPB41L2	2037	broad.mit.edu	37	chr6	131190961	131190961	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctctctactaccttggctgcCgggcggggttcttcctccac	10	16	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:131190961C>T	uc003qch.2	-	15	2531	c.2349G>A	c.(2347-2349)CCG>CCA	p.P783P	EPB41L2_uc003qce.1_Silent_p.P161P|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Silent_p.P713P|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Silent_p.P713P|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Silent_p.P180P	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	783					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CCTTGGCTGCCGGGCGGGGTT	0.577													0	0	0	0.01441	0	47	220										T	131190961	C	T	131190961	2	4	74	1	0	0	0	0	0	0	0	1	5153	639	23	2		2	EPB41L2	6	131190961	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1617539	131190961	39924106	107	22659										
TAAR9	134860	broad.mit.edu	37	chr6	132860331	132860331	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	attttagtttggtgtgtttaTtataattcagctatgaaccc	7	5	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:132860331T>A	uc011eci.1	+	2	905	c.903T>A	c.(901-903)TAT>TAA	p.Y301*		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	301	Helical; Name=7; (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		GGTGTGTTTATTATAATTCAG	0.348													0	0	0	0.014758	0	4	12										A	132860331	T	A	132860331	4	1	74	1	0	0	0	0	0	1	0	0	15491	1500	52	5	905	5	TAAR9	6	132860331	Nonsense_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	1669370	132860331	38254736	108	22660										
SHPRH	257218	broad.mit.edu	37	chr6	146256489	146256489	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tagagatgctgaggattcttCttgcagtaaggccgatagag	13	6	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:146256489C>G	uc003qlf.2	-	12	3057	c.2658G>C	c.(2656-2658)AAG>AAC	p.K886N	SHPRH_uc003qld.2_Missense_Mutation_p.K886N|SHPRH_uc003qle.2_Missense_Mutation_p.K886N|SHPRH_uc003qlg.1_Missense_Mutation_p.K442N|SHPRH_uc003qlj.1_Missense_Mutation_p.K775N|SHPRH_uc003qlh.2_5'Flank	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	886					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GAGGATTCTTCTTGCAGTAAG	0.393													0	0	0	0.020292	0	14	47										G	146256489	C	G	146256489	3	3	74	1	0	0	0	0	1	0	0	0	14291	912	32	1	2513	1	SHPRH	6	146256489	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	13396158	146256489	24858578	109	22661										
IPCEF1	26034	broad.mit.edu	37	chr6	154521101	154521101	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aactgctgggtgtcttcactGtattttccagggaagagaaa	11	7	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:154521101G>T	uc003qpx.2	-	10	764	c.608C>A	c.(607-609)ACA>AAA	p.T203K	OPRM1_uc003qpt.1_Intron|IPCEF1_uc003qpv.2_Missense_Mutation_p.T74K|IPCEF1_uc003qpw.2_Missense_Mutation_p.T204K|IPCEF1_uc010kjh.2_Missense_Mutation_p.T204K	NM_015553	NP_056368	Q8WWN9	ICEF1_HUMAN	phosphoinositide-binding protein PIP3-E isoform	203	Ser-rich.				response to oxidative stress	cytoplasm|plasma membrane	oxygen transporter activity|peroxidase activity				0						TGTCTTCACTGTATTTTCCAG	0.433													1	0	0.00621372	0.006214	0.00631699	8	91										T	154521101	G	T	154521101	3	4	74	1	0	0	0	0	1	0	0	0	7791	1377	48	4	717	4	IPCEF1	6	154521101	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	8264612	154521101	16593966	110	22662										
FNDC1	84624	broad.mit.edu	37	chr6	159653694	159653694	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cagtgcctcagccccaccctCaagactttctccaccccatg	5	20	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr6:159653694C>G	uc010kjv.2	+	11	2350	c.2150C>G	c.(2149-2151)TCA>TGA	p.S717*	FNDC1_uc010kjw.1_Nonsense_Mutation_p.S602*	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	717	Ser-rich.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GCCCCACCCTCAAGACTTTCT	0.657													0	0	0	0.02938	0	7	16										G	159653694	C	G	159653694	4	3	74	1	0	0	0	0	0	1	0	0	5968	838	29	1	2192	1	FNDC1	6	159653694	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5132593	159653694	11461373	111	22663										
ZNF12	7559	broad.mit.edu	37	chr7	6730643	6730643	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tacagtgaggtatgacatccGagagaaggcttttccacact	10	9	0	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:6730643G>A	uc003sqt.1	-	5	2484	c.1930C>T	c.(1930-1932)CGG>TGG	p.R644W	ZNF12_uc011jxa.1_Missense_Mutation_p.R482W|ZNF12_uc003sqs.1_Missense_Mutation_p.R606W	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	644	C2H2-type 14.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TATGACATCCGAGAGAAGGCT	0.393													0	0	0	0.01441	0	46	95										A	6730643	G	A	6730643	3	1	74	1	0	0	0	0	1	0	0	0	17715	1057	37	1	167	1	ZNF12	7	6730643	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		6730643	152408020	112	22664			2	103		3	3	239	G		2.878603e-06
ZNF12	7559	broad.mit.edu	37	chr7	6730858	6730858	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	attcatagggcttctctcctGaatgaattctatgatgtata	7	7	3	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:6730858G>A	uc003sqt.1	-	5	2269	c.1715C>T	c.(1714-1716)TCA>TTA	p.S572L	ZNF12_uc011jxa.1_Missense_Mutation_p.S410L|ZNF12_uc003sqs.1_Missense_Mutation_p.S534L	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	572					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CTTCTCTCCTGAATGAATTCT	0.413													0	0	0	0.012319	0	16	65										A	6730858	G	A	6730858	3	1	74	1	0	0	0	0	1	0	0	0	17715	1294	45	1	382	1	ZNF12	7	6730858	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	215	6730858	152407805	113	22665			2	103		3	3	239	G		2.878603e-06
ZNF12	7559	broad.mit.edu	37	chr7	6730881	6730881	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgaattctatgatgtatagtGaggtatgacatctgagagaa	11	3	2	6			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:6730881G>C	uc003sqt.1	-	5	2246	c.1692C>G	c.(1690-1692)CTC>CTG	p.L564L	ZNF12_uc011jxa.1_Silent_p.L402L|ZNF12_uc003sqs.1_Silent_p.L526L	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	564	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GATGTATAGTGAGGTATGACA	0.408													0	0	0	0.008871	0	15	58										C	6730881	G	C	6730881	2	2	74	1	0	0	0	0	0	0	0	1	17715	1277	45	1		1	ZNF12	7	6730881	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	23	6730881	152407782	114	22666			2	103		3	3	239	G		2.878603e-06
DGKB	1607	broad.mit.edu	37	chr7	14724975	14724975	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcgccacacgtgctgtccatCatccttcacgttctgcatgg	8	15	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:14724975C>T	uc003ssz.2	-	9	911	c.724G>A	c.(724-726)GAT>AAT	p.D242N	DGKB_uc011jxt.1_Missense_Mutation_p.D235N|DGKB_uc003sta.2_Missense_Mutation_p.D242N|DGKB_uc011jxu.1_Missense_Mutation_p.D242N|DGKB_uc011jxv.1_Missense_Mutation_p.D242N	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	242					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TGCTGTCCATCATCCTTCACG	0.463													0	0	0	0.021523	0	19	72										T	14724975	C	T	14724975	3	4	74	1	0	0	0	0	1	0	0	0	4466	826	29	1	1773	1	DGKB	7	14724975	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7994094	14724975	144413688	115	22667										
DNAH11	8701	broad.mit.edu	37	chr7	21723453	21723453	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcaacttcgtcaccgatggGaggatacccagaaacactgc	9	13	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:21723453G>T	uc003svc.2	+	33	5564	c.5533G>T	c.(5533-5535)GAG>TAG	p.E1845*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1845	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCACCGATGGGAGGATACCCA	0.458									Kartagener_syndrome				1	0	3.28156e-27	0.01441	3.76353e-27	50	279										T	21723453	G	T	21723453	4	4	74	1	0	0	0	0	0	1	0	0	4599	1175	41	3	5660	3	DNAH11	7	21723453	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	6998478	21723453	137415210	116	22668										
STK31	56164	broad.mit.edu	37	chr7	23802426	23802426	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttttcttcctccagagtgaaGggaatattttgattgcccaa	8	8	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:23802426G>A	uc003sws.3	+	11	1367	c.1300G>A	c.(1300-1302)GGG>AGG	p.G434R	STK31_uc003swt.3_Missense_Mutation_p.G411R|STK31_uc011jze.1_Missense_Mutation_p.G434R|STK31_uc010kuq.2_Missense_Mutation_p.G411R	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	434							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CCAGAGTGAAGGGAATATTTT	0.333													0	0	0	0.027894	0	37	66										A	23802426	G	A	23802426	3	1	74	1	0	0	0	0	1	0	0	0	15295	1000	35	2	1342	2	STK31	7	23802426	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2078973	23802426	135336237	117	22669										
ADCYAP1R1	117	broad.mit.edu	37	chr7	31132288	31132288	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgctttttattggcattatcGtcatccttgtgcagaaactt	7	8	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:31132288G>T	uc003tca.1	+	13	1208	c.985G>T	c.(985-987)GTC>TTC	p.V329F	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.V308F|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.V329F|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.V329F|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.V329F|ADCYAP1R1_uc003tcf.1_Missense_Mutation_p.V31F	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	329	Helical; Name=5; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TGGCATTATCGTCATCCTTGT	0.428													1	0	4.7546e-09	0.028581	5.20878e-09	15	73										T	31132288	G	T	31132288	3	4	74	1	0	0	0	0	1	0	0	0	303	1145	40	4	1031	4	ADCYAP1R1	7	31132288	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	7329862	31132288	128006375	118	22670										
OGDH	4967	broad.mit.edu	37	chr7	44734097	44734097	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccgctcatgtacaagcagatCcgcaagcagaagcctgtgtt	10	12	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:44734097C>T	uc003tln.2	+	12	1699	c.1590C>T	c.(1588-1590)ATC>ATT	p.I530I	OGDH_uc011kbx.1_Silent_p.I526I|OGDH_uc011kby.1_Silent_p.I380I|OGDH_uc003tlp.2_Silent_p.I541I|OGDH_uc011kbz.1_Silent_p.I325I|OGDH_uc003tlo.1_Silent_p.I363I	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	530					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	ACAAGCAGATCCGCAAGCAGA	0.572													0	0	0	0.037714	0	25	61										T	44734097	C	T	44734097	2	4	74	1	0	0	0	0	0	0	0	1	10839	845	30	1		1	OGDH	7	44734097	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	13601809	44734097	114404566	119	22671										
HUS1	3364	broad.mit.edu	37	chr7	48004979	48004979	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cagcgcagggatgaaatactGaagggacacgtcttcatgaa	12	8	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:48004979G>A	uc003tod.1	-	8	947	c.817C>T	c.(817-819)CAG>TAG	p.Q273*	HUS1_uc003toe.1_Nonsense_Mutation_p.Q273*|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	273					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)				ATGAAATACTGAAGGGACACG	0.483								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.025465	0	33	115										A	48004979	G	A	48004979	4	1	74	1	0	0	0	0	0	1	0	0	7459	1299	45	1	29	1	HUS1	7	48004979	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3270882	48004979	111133684	120	22672										
CCT6A	908	broad.mit.edu	37	chr7	56126340	56126340	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	accccttttccttagatgctCtttcaaaagaaggcatagtt	6	10	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:56126340C>G	uc003trl.1	+	8	1077	c.913C>G	c.(913-915)CTT>GTT	p.L305V	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Missense_Mutation_p.L260V|CCT6A_uc011kcu.1_Missense_Mutation_p.L274V|SNORA15_uc003trn.1_5'Flank	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	305					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTTAGATGCTCTTTCAAAAGA	0.343													0	0	0	0.0333	0	14	45										G	56126340	C	G	56126340	3	3	74	1	0	0	0	0	1	0	0	0	2957	913	32	1	943	1	CCT6A	7	56126340	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	8121361	56126340	103012323	121	22673										
CROT	54677	broad.mit.edu	37	chr7	87020948	87020948	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctatgacaagacatttttatCatggccgtacagagactatg	8	8	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:87020948C>T	uc003uit.2	+	14	1590	c.1345C>T	c.(1345-1347)CAT>TAT	p.H449Y	CROT_uc003uiu.2_Missense_Mutation_p.H477Y	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	449					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	ACATTTTTATCATGGCCGTAC	0.388													0	0	0	0.037714	0	23	46										T	87020948	C	T	87020948	3	4	74	1	0	0	0	0	1	0	0	0	3894	826	29	1	1479	1	CROT	7	87020948	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	30894608	87020948	72117715	122	22674										
DBF4	10926	broad.mit.edu	37	chr7	87529553	87529553	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tagactttataggccattttAtcttcagctgaccaatatgc	6	9	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:87529553A>G	uc003ujf.1	+	9	1202	c.698A>G	c.(697-699)TAT>TGT	p.Y233C	DBF4_uc003ujh.1_Intron|DBF4_uc003ujg.1_Missense_Mutation_p.Y9C|DBF4_uc011khf.1_Intron	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	233					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				AGGCCATTTTATCTTCAGCTG	0.299													0	0	0	0.008291	0	9	66										G	87529553	A	G	87529553	3	3	74	1	0	0	0	0	1	0	0	0	4248	449	16	5	732	5	DBF4	7	87529553	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	508605	87529553	71609110	123	22675										
MTERF	7978	broad.mit.edu	37	chr7	91503486	91503486	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	catctgtttattcagatcaaGactattggagaaggtacgag	10	6	3	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:91503486G>C	uc003ulb.1	-	2	666	c.622C>G	c.(622-624)CTT>GTT	p.L208V	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Missense_Mutation_p.L208V|MTERF_uc011khm.1_Missense_Mutation_p.L188V|MTERF_uc010leu.1_Missense_Mutation_p.L188V	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	208					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			TTCAGATCAAGACTATTGGAG	0.383													0	0	0	0.013537	0	12	66										C	91503486	G	C	91503486	3	2	74	1	0	0	0	0	1	0	0	0	9918	942	33	1	581	1	MTERF	7	91503486	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3973933	91503486	67635177	124	22676										
COL1A2	1278	broad.mit.edu	37	chr7	94053674	94053674	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctggcactccaggtcctcaGggtcttcttggtgctcctgg	12	14	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:94053674G>A	uc003ung.1	+	41	3063	c.2592G>A	c.(2590-2592)CAG>CAA	p.Q864Q	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_RNA	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	864					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CAGGTCCTCAGGGTCTTCTTG	0.498										HNSCC(75;0.22)			0	0	0	0.020292	0	10	94										A	94053674	G	A	94053674	2	1	74	1	0	0	0	0	0	0	0	1	3678	991	35	2		2	COL1A2	7	94053674	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2550188	94053674	65084989	125	22677										
TMEM130	222865	broad.mit.edu	37	chr7	98449087	98449087	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tggtactgatgtgtcttgctGatgatattctcggcccggat	12	8	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:98449087G>C	uc003upo.2	-	6	1152	c.963C>G	c.(961-963)ATC>ATG	p.I321M	TMEM130_uc011kiq.1_Missense_Mutation_p.I302M|TMEM130_uc011kir.1_Missense_Mutation_p.I321M|TMEM130_uc003upn.2_Missense_Mutation_p.I219M	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	321	Extracellular (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GTGTCTTGCTGATGATATTCT	0.582													0	0	0	0.016723	0	11	106										C	98449087	G	C	98449087	3	2	74	1	0	0	0	0	1	0	0	0	16040	1280	45	1	356	1	TMEM130	7	98449087	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4395413	98449087	60689576	126	22678										
ZKSCAN5	23660	broad.mit.edu	37	chr7	99123756	99123756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctcaaactttattcagcatCggcgcatccacactggagaa	7	13	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:99123756C>T	uc003uqv.2	+	6	1217	c.1093C>T	c.(1093-1095)CGG>TGG	p.R365W	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.R365W|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.R365W|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.R292W|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.R101W	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	365	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TATTCAGCATCGGCGCATCCA	0.537													0	0	0	0.020292	0	14	82										T	99123756	C	T	99123756	3	4	74	1	0	0	0	0	1	0	0	0	17687	875	31	1	1111	1	ZKSCAN5	7	99123756	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	674669	99123756	60014907	127	22679										
VGF	7425	broad.mit.edu	37	chr7	100806828	100806828	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cccgccctcctctgtcccctCggcctccttccgccggtggc	9	23	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:100806828C>T	uc003uxx.3	-	2	1515	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	433	Asp/Glu-rich (acidic).				response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					tctgtcccctcggcctccttc	0.493													0	0	0	0.004482	0	9	9										T	100806828	C	T	100806828	3	4	74	1	0	0	0	0	1	0	0	0	17154	893	31	1	554	1	VGF	7	100806828	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1683072	100806828	58331835	128	22680										
PTPRZ1	5803	broad.mit.edu	37	chr7	121650934	121650934	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aagggtatatattttcctccGaaaacccagagacaataaca	6	9	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:121650934G>A	uc003vjy.2	+	12	2229	c.1834G>A	c.(1834-1836)GAA>AAA	p.E612K	PTPRZ1_uc003vjz.2_Missense_Mutation_p.E612K|PTPRZ1_uc011knt.1_Missense_Mutation_p.E62K	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	612	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATTTTCCTCCGAAAACCCAGA	0.418													0	0	0	0.024245	0	12	33										A	121650934	G	A	121650934	3	1	74	1	0	0	0	0	1	0	0	0	12814	1059	37	1	1880	1	PTPRZ1	7	121650934	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	20844106	121650934	37487729	129	22681										
PLXNA4	91584	broad.mit.edu	37	chr7	131866328	131866328	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctggtggtcaggacccagagCgagggcgggcgcctgacagg	19	11	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:131866328C>T	uc003vra.3	-	18	3533	c.3304G>A	c.(3304-3306)GCT>ACT	p.A1102T		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1102	Extracellular (Potential).|IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGACCCAGAGCGAGGGCGGGC	0.577													0	0	0	0.014323	0	21	36										T	131866328	C	T	131866328	3	4	74	1	0	0	0	0	1	0	0	0	12122	768	27	2	2440	2	PLXNA4	7	131866328	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10215394	131866328	27272335	130	22682										
DGKI	9162	broad.mit.edu	37	chr7	137150661	137150661	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaagcacactcaccccgaggCttgttccaccaccaggtcag	9	16	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:137150661C>T	uc003vtt.2	-	27	2630	c.2629G>A	c.(2629-2631)GCC>ACC	p.A877T	DGKI_uc003vtu.2_Missense_Mutation_p.A587T	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	877					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CACCCCGAGGCTTGTTCCACC	0.542													0	0	0	0.013537	0	10	59										T	137150661	C	T	137150661	3	4	74	1	0	0	0	0	1	0	0	0	4471	797	28	2	600	2	DGKI	7	137150661	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5284333	137150661	21988002	131	22683										
FAM115C	285966	broad.mit.edu	37	chr7	143417071	143417071	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aagttggggtgaacacaaatCtaaaagatctgtgtcctctc	9	8	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:143417071C>G	uc003wdf.2	+	3	1002	c.919C>G	c.(919-921)CTA>GTA	p.L307V	FAM115C_uc003wdg.2_Missense_Mutation_p.L26V|FAM115C_uc011ktk.1_Missense_Mutation_p.L307V|FAM115C_uc003wdh.2_Missense_Mutation_p.L307V|FAM115C_uc011ktm.1_Missense_Mutation_p.L307V|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Missense_Mutation_p.L143V|FAM115C_uc003wdi.1_Missense_Mutation_p.L26V	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	307											0						GAACACAAATCTAAAAGATCT	0.572													0	0	0	0.014758	0	5	26										G	143417071	C	G	143417071	3	3	74	1	0	0	0	0	1	0	0	0	5406	912	32	1	1060	1	FAM115C	7	143417071	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6266410	143417071	15721592	132	22684										
ZNF777	27153	broad.mit.edu	37	chr7	149128965	149128966	+	Frame_Shift_Del	DEL	GC	GC	-													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtagggccgctcgcccgtgtGcgcgcgctggtgctccagca							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr7:149128965_149128966delGC	uc003wfv.2	-	6	2560_2561	c.2397_2398delGC	c.(2395-2400)GCGCACfs	p.A799fs		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	Error:Variant_position_missing_in_Q9ULD5_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCGCCCGTGTGCGCGCGCTGGT	0.668																		8	43	---	---								-	149128966	GC	-	149128965	7	5	74	1	0	1	0	1	0	0	0	0	18147	1319	46	0	101	0	ZNF777	7	149128965	Frame_Shift_Del	DEL	GC	TCGA-FD-A3B6-01A-21D-A20D-08	5711894	149128965	10009698	133	22685										
ANK1	286	broad.mit.edu	37	chr8	41554068	41554068	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtggcgacttcctctcatggAaccaccccgggcgtcaacca	10	16	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:41554068A>T	uc003xok.2	-	26	2857	c.2773T>A	c.(2773-2775)TCC>ACC	p.S925T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.S241T|ANK1_uc003xoi.2_Missense_Mutation_p.S925T|ANK1_uc003xoj.2_Missense_Mutation_p.S925T|ANK1_uc003xol.2_Missense_Mutation_p.S925T|ANK1_uc003xom.2_Missense_Mutation_p.S966T	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	925	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCTCTCATGGAACCACCCCGG	0.637													0	0	0	0.020292	0	14	25										T	41554068	A	T	41554068	3	4	74	1	0	0	0	0	1	0	0	0	620	246	9	5	3266	5	ANK1	8	41554068	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08		41554068	104809954	134	22686										
KIAA0146	23514	broad.mit.edu	37	chr8	48309024	48309024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	actcattgattcagaatcccCtcacaaataccacgtgcagt	5	13	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:48309024C>T	uc003xqd.2	+	6	623	c.614C>T	c.(613-615)CCT>CTT	p.P205L	KIAA0146_uc011lcz.1_Intron|KIAA0146_uc011lda.1_Intron|KIAA0146_uc011ldb.1_Missense_Mutation_p.P205L|KIAA0146_uc010lxs.2_5'UTR|KIAA0146_uc011ldc.1_Missense_Mutation_p.P135L|KIAA0146_uc011ldd.1_Missense_Mutation_p.P145L|KIAA0146_uc003xqe.2_Intron|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Intron	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	205											0		Lung NSC(58;0.175)				TCAGAATCCCCTCACAAATAC	0.363													0	0	0	0.024245	0	14	87										T	48309024	C	T	48309024	3	4	74	1	0	0	0	0	1	0	0	0	8157	681	24	2	636	2	KIAA0146	8	48309024	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6754956	48309024	98054998	135	22687										
TRAM1	23471	broad.mit.edu	37	chr8	71520314	71520314	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gactcggggcgggctcacctCaaacatgagccccagcagga	13	14	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:71520314C>G	uc003xyo.1	-	1	291	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	TRAM1_uc011lfc.1_Missense_Mutation_p.E10Q	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	41	Helical; (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GGGCTCACCTCAAACATGAGC	0.692													0	0	0	0.004672	0	3	33										G	71520314	C	G	71520314	3	3	74	1	0	0	0	0	1	0	0	0	16448	835	29	1	1047	1	TRAM1	8	71520314	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	23211290	71520314	74843708	136	22688										
ZNF572	137209	broad.mit.edu	37	chr8	125987911	125987911	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agaaaaaaaactgttggtctCagattctaacagctttatgg	8	6	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:125987911C>T	uc003yrr.2	+	2	184	c.29C>T	c.(28-30)TCA>TTA	p.S10L		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTGTTGGTCTCAGATTCTAAC	0.378										HNSCC(60;0.17)			0	0	0	0.014323	0	16	117										T	125987911	C	T	125987911	3	4	74	1	0	0	0	0	1	0	0	0	18001	838	29	1	31	1	ZNF572	8	125987911	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	54467597	125987911	20376111	137	22689										
ZNF572	137209	broad.mit.edu	37	chr8	125988884	125988884	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgcctgtgtccagcagaattCatcctttgtagacagaccct	8	12	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:125988884C>T	uc003yrr.2	+	3	529	c.374C>T	c.(373-375)TCA>TTA	p.S125L		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CAGCAGAATTCATCCTTTGTA	0.428										HNSCC(60;0.17)			0	0	0	0.020292	0	14	120										T	125988884	C	T	125988884	3	4	74	1	0	0	0	0	1	0	0	0	18001	838	29	1	380	1	ZNF572	8	125988884	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	973	125988884	20375138	138	22690										
ZNF572	137209	broad.mit.edu	37	chr8	125989705	125989705	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gttttggccttagctcccatCtcattagacatcagagaaca	7	11	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:125989705C>G	uc003yrr.2	+	3	1350	c.1195C>G	c.(1195-1197)CTC>GTC	p.L399V		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	399	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TAGCTCCCATCTCATTAGACA	0.428										HNSCC(60;0.17)			0	0	0	0.008871	0	15	107										G	125989705	C	G	125989705	3	3	74	1	0	0	0	0	1	0	0	0	18001	913	32	1	1201	1	ZNF572	8	125989705	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	821	125989705	20374317	139	22691										
EFR3A	23167	broad.mit.edu	37	chr8	132991207	132991207	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaactgagacagttggtcttGgaagtaatgcataatctcat	10	6	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:132991207G>T	uc003yte.2	+	13	1641	c.1440G>T	c.(1438-1440)TTG>TTT	p.L480F		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	480						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			AGTTGGTCTTGGAAGTAATGC	0.418													1	0	3.65163e-15	0.030593	4.09831e-15	21	184										T	132991207	G	T	132991207	3	4	74	1	0	0	0	0	1	0	0	0	4958	1339	47	4	1490	4	EFR3A	8	132991207	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	7001502	132991207	13372815	140	22692										
PLEC	5339	broad.mit.edu	37	chr8	144991923	144991923	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atggcctggaagagggagatGagcttcccagagtaggggtc	17	7	0	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:144991923G>T	uc003zaf.1	-	32	12647	c.12477C>A	c.(12475-12477)CTC>CTA	p.L4159L	PLEC_uc003zab.1_Silent_p.L4022L|PLEC_uc003zac.1_Silent_p.L4026L|PLEC_uc003zad.2_Silent_p.L4022L|PLEC_uc003zae.1_Silent_p.L3990L|PLEC_uc003zag.1_Silent_p.L4000L|PLEC_uc003zah.2_Silent_p.L4008L|PLEC_uc003zaj.2_Silent_p.L4049L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4159	Globular 2.|Plectin 24.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGAGGGAGATGAGCTTCCCAG	0.632													1	0	2.61681e-11	0.020292	2.91021e-11	12	54										T	144991923	G	T	144991923	2	4	74	1	0	0	0	0	0	0	0	1	12052	1277	45	3		3	PLEC	8	144991923	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	12000716	144991923	1372099	141	22693										
MFSD3	113655	broad.mit.edu	37	chr8	145736008	145736008	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgcctctgttgaggtcggtGctgcgcttccgcctcggggg	16	13	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr8:145736008G>T	uc003zdi.1	+	3	1023	c.858G>T	c.(856-858)GTG>GTT	p.V286V		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	286	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGAGGTCGGTGCTGCGCTTCC	0.617													1	0	2.68985e-26	0.01441	3.07531e-26	36	190										T	145736008	G	T	145736008	2	4	74	1	0	0	0	0	0	0	0	1	9532	1306	46	4		4	MFSD3	8	145736008	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	744085	145736008	628014	142	22694										
DMRT2	10655	broad.mit.edu	37	chr9	1057268	1057268	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgccatcactcgtgtctctCagtgaaaggctgcttaaaca	8	12	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:1057268C>T	uc003zha.2	+	4	1881	c.1681C>T	c.(1681-1683)CAG>TAG	p.Q561*	DMRT2_uc003zgx.3_Nonsense_Mutation_p.Q328*|DMRT2_uc010mgz.2_Nonsense_Mutation_p.Q328*|DMRT2_uc003zgy.3_Nonsense_Mutation_p.Q405*|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Nonsense_Mutation_p.Q561*	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	561					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TCGTGTCTCTCAGTGAAAGGC	0.383													0	0	0	0.012319	0	18	112										T	1057268	C	T	1057268	4	4	74	1	0	0	0	0	0	1	0	0	4586	827	29	1	1748	1	DMRT2	9	1057268	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08		1057268	140156163	143	22695										
GLIS3	169792	broad.mit.edu	37	chr9	3898796	3898796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggactgcacggtgaggcaatCtgtgagcaggtctggatgga	17	7	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:3898796C>G	uc003zhw.1	-	6	1752	c.1558G>C	c.(1558-1560)GAT>CAT	p.D520H	GLIS3_uc003zhx.1_Missense_Mutation_p.D675H|GLIS3_uc010mhf.1_Missense_Mutation_p.D69H|GLIS3_uc003zhv.1_RNA|GLIS3_uc003zhy.1_Missense_Mutation_p.D453H|GLIS3_uc003zhz.1_Missense_Mutation_p.D453H|C9orf70_uc003zia.2_RNA	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	520					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GTGAGGCAATCTGTGAGCAGG	0.587													0	0	0	0.010818	0	29	55										G	3898796	C	G	3898796	3	3	74	1	0	0	0	0	1	0	0	0	6447	913	32	1	789	1	GLIS3	9	3898796	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2841528	3898796	137314635	144	22696										
KIAA1432	57589	broad.mit.edu	37	chr9	5746003	5746003	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aaaacactgaaattgagtctGacctcaggagtgtagttaaa	9	6	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:5746003G>A	uc003zji.2	+	10	1024	c.931G>A	c.(931-933)GAC>AAC	p.D311N	KIAA1432_uc003zjh.2_Missense_Mutation_p.D311N|KIAA1432_uc003zjl.3_Missense_Mutation_p.D311N|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	390						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AATTGAGTCTGACCTCAGGAG	0.408													0	0	0	0.024334	0	21	126										A	5746003	G	A	5746003	3	1	74	1	0	0	0	0	1	0	0	0	8233	1290	45	1	969	1	KIAA1432	9	5746003	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1847207	5746003	135467428	145	22697										
IFNA16	3449	broad.mit.edu	37	chr9	21216778	21216778	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tttgcaagtttgttgaaaaaGagaaggatctcatgatttct	9	4	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:21216778G>C	uc003zor.1	-	1	533	c.527C>G	c.(526-528)TCT>TGT	p.S176C	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	176					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGTTGAAAAAGAGAAGGATCT	0.373													0	0	0	0.01441	0	169	278										C	21216778	G	C	21216778	3	2	74	1	0	0	0	0	1	0	0	0	7535	942	33	1	46	1	IFNA16	9	21216778	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	15470775	21216778	119996653	146	22698										
LINGO2	158038	broad.mit.edu	37	chr9	27950351	27950351	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttttaggcggagggaacgcaGgttaaagagattgttgaatg	15	3	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:27950351G>A	uc003zqu.1	-	2	513	c.319C>T	c.(319-321)CTG>TTG	p.L107L	LINGO2_uc010mjf.1_Silent_p.L107L|LINGO2_uc003zqv.1_Silent_p.L107L	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	107	LRR 3.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		AGGGAACGCAGGTTAAAGAGA	0.448													0	0	0	0.01441	0	78	121										A	27950351	G	A	27950351	2	1	74	1	0	0	0	0	0	0	0	1	8815	991	35	2		2	LINGO2	9	27950351	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	6733573	27950351	113263080	147	22699										
TAF1L	138474	broad.mit.edu	37	chr9	32632499	32632499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcaggcacaccaaatttacGtagaagttgcttggcatttt	8	9	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:32632499G>A	uc003zrg.1	-	1	3169	c.3079C>T	c.(3079-3081)CGT>TGT	p.R1027C	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1027					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CCAAATTTACGTAGAAGTTGC	0.473													0	0	0	0.01441	0	42	275										A	32632499	G	A	32632499	3	1	74	1	0	0	0	0	1	0	0	0	15520	1145	40	2	2405	2	TAF1L	9	32632499	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4682148	32632499	108580932	148	22700										
TRPM6	140803	broad.mit.edu	37	chr9	77376712	77376712	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctccctgccctatttctgaaGagcctgaaagatctgcaagg	9	12	2	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:77376712G>C	uc004ajl.1	-	27	4923	c.4685C>G	c.(4684-4686)TCT>TGT	p.S1562C	TRPM6_uc004ajk.1_Missense_Mutation_p.S1557C|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.S518C	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1562	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TATTTCTGAAGAGCCTGAAAG	0.428													0	0	0	0.008871	0	15	43										C	77376712	G	C	77376712	3	2	74	1	0	0	0	0	1	0	0	0	16587	942	33	1	1435	1	TRPM6	9	77376712	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	44744213	77376712	63836719	149	22701										
VPS13A	23230	broad.mit.edu	37	chr9	79898509	79898509	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccttcagaaactgaaataaaCgcaaagctaaggaatataat	6	7	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:79898509C>T	uc004akr.2	+	31	3542	c.3282C>T	c.(3280-3282)AAC>AAT	p.N1094N	VPS13A_uc004akp.3_Silent_p.N1094N|VPS13A_uc004akq.3_Silent_p.N1094N|VPS13A_uc004aks.2_Silent_p.N1055N	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1094					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CTGAAATAAACGCAAAGCTAA	0.284													0	0	0	0.014323	0	18	28										T	79898509	C	T	79898509	2	4	74	1	0	0	0	0	0	0	0	1	17186	535	19	2		2	VPS13A	9	79898509	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2521797	79898509	61314922	150	22702										
TLE1	7088	broad.mit.edu	37	chr9	84230956	84230956	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgaggaggccgtggaagctgGactgctagaagcatccttct	14	10	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:84230956G>C	uc004aly.2	-	11	1300	c.859C>G	c.(859-861)CCA>GCA	p.P287A	TLE1_uc004alz.2_Missense_Mutation_p.P297A|TLE1_uc011lsr.1_Missense_Mutation_p.P287A|TLE1_uc004ama.1_Missense_Mutation_p.P287A|TLE1_uc011lss.1_Missense_Mutation_p.P213A	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	287	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GTGGAAGCTGGACTGCTAGAA	0.502													0	0	0	0.024245	0	15	75										C	84230956	G	C	84230956	3	2	74	1	0	0	0	0	1	0	0	0	15935	1174	41	1	1493	1	TLE1	9	84230956	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4332447	84230956	56982475	151	22703										
MRPL50	54534	broad.mit.edu	37	chr9	104153059	104153059	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tggtgtgtatgctcggcttcGtaaaggtggacacactagga	14	7	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:104153059G>C	uc004bbe.2	-	2	211	c.166C>G	c.(166-168)CGA>GGA	p.R56G	MRPL50_uc011lvj.1_Missense_Mutation_p.R56G	NM_019051	NP_061924	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	56						mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)				GCTCGGCTTCGTAAAGGTGGA	0.408													0	0	0	0.021523	0	18	58										C	104153059	G	C	104153059	3	2	74	1	0	0	0	0	1	0	0	0	9814	1153	40	4	314	4	MRPL50	9	104153059	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	19922103	104153059	37060372	152	22704										
OR13C5	138799	broad.mit.edu	37	chr9	107360932	107360932	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttcatgtacatgaggaagaTggtcccacagaatgttatca	9	8	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr9:107360932T>C	uc011lvp.1	-	1	763	c.763A>G	c.(763-765)ATC>GTC	p.I255V		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						ATGAGGAAGATGGTCCCACAG	0.438													0	0	0	0.017118	0	30	49										C	107360932	T	C	107360932	3	2	74	1	0	0	0	0	1	0	0	0	10937	1464	51	5	195	5	OR13C5	9	107360932	Missense_Mutation	SNP	T	TCGA-FD-A3B6-01A-21D-A20D-08	3207873	107360932	33852499	153	22705										
ADARB2	105	broad.mit.edu	37	chr10	1405318	1405318	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggcctgcgcggcctgaccccGggccagcttcttgctgcgcc	14	18	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:1405318G>A	uc009xhq.2	-	3	1356	c.982C>T	c.(982-984)CGG>TGG	p.R328W		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	328	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCCTGACCCCGGGCCAGCTTC	0.726													0	0	0	0.00308	0	5	9										A	1405318	G	A	1405318	3	1	74	1	0	0	0	0	1	0	0	0	283	1115	39	2	1269	2	ADARB2	10	1405318	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		1405318	134129429	154	22706										
SVIL	6840	broad.mit.edu	37	chr10	29840096	29840096	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tggtacccgaaccatagggtGagtcaccgtggacaccggag	14	11	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:29840096G>A	uc001iut.1	-	6	1010	c.257C>T	c.(256-258)TCA>TTA	p.S86L	SVIL_uc001iuu.1_Missense_Mutation_p.S86L|SVIL_uc009xld.1_Missense_Mutation_p.S86L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	86	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				ACCATAGGGTGAGTCACCGTG	0.493													0	0	0	0.007413	0	16	95										A	29840096	G	A	29840096	3	1	74	1	0	0	0	0	1	0	0	0	15418	1294	45	1	6519	1	SVIL	10	29840096	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	28434778	29840096	105694651	155	22707										
SVIL	6840	broad.mit.edu	37	chr10	29840154	29840154	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggatcgagtttgcttttctaGagaagaatcagaagtttcct	10	6	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:29840154G>T	uc001iut.1	-	6	952	c.199C>A	c.(199-201)CTA>ATA	p.L67I	SVIL_uc001iuu.1_Missense_Mutation_p.L67I|SVIL_uc009xld.1_Missense_Mutation_p.L67I	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	67	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGCTTTTCTAGAGAAGAATCA	0.463													1	0	4.7546e-09	0.028581	5.20878e-09	12	47										T	29840154	G	T	29840154	3	4	74	1	0	0	0	0	1	0	0	0	15418	933	33	3	6577	3	SVIL	10	29840154	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	58	29840154	105694593	156	22708										
LRRTM3	347731	broad.mit.edu	37	chr10	68687354	68687354	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caacctggccctttttccaaGgttggtcagccttcagaacc	8	14	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:68687354G>C	uc001jmz.1	+	2	1230	c.680G>C	c.(679-681)AGG>ACG	p.R227T	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.R227T	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	227	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTTTTTCCAAGGTTGGTCAGC	0.453													0	0	0	0.024334	0	20	107										C	68687354	G	C	68687354	3	2	74	1	0	0	0	0	1	0	0	0	9041	1000	35	4	686	4	LRRTM3	10	68687354	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	38847200	68687354	66847393	157	22709										
TSPAN15	23555	broad.mit.edu	37	chr10	71265936	71265936	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgcaccaacgccgtgatcatCtggttcatggacaactacac	8	13	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:71265936C>G	uc001jpo.1	+	7	800	c.675C>G	c.(673-675)ATC>ATG	p.I225M		NM_012339	NP_036471	O95858	TSN15_HUMAN	transmembrane 4 superfamily member 15	225	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						CCGTGATCATCTGGTTCATGG	0.597													0	0	0	0.01441	0	102	76										G	71265936	C	G	71265936	3	3	74	1	0	0	0	0	1	0	0	0	16636	903	32	1	701	1	TSPAN15	10	71265936	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2578582	71265936	64268811	158	22710										
COL13A1	1305	broad.mit.edu	37	chr10	71562459	71562459	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctattttgggacgagtcaatCaactgctggacgaggtctgt	12	8	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:71562459C>T	uc001jpr.1	+	1	816	c.280C>T	c.(280-282)CAA>TAA	p.Q94*	COL13A1_uc001jqj.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jps.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpt.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpu.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpv.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpx.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpw.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpy.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jpz.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqa.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqc.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqb.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jql.2_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqd.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqe.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqf.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqg.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqh.1_Nonsense_Mutation_p.Q94*|COL13A1_uc001jqi.1_Nonsense_Mutation_p.Q94*	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	94	Extracellular (Potential).|Nonhelical region 1 (NC1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	ACGAGTCAATCAACTGCTGGA	0.662													0	0	0	0.015359	0	32	404										T	71562459	C	T	71562459	4	4	74	1	0	0	0	0	0	1	0	0	3670	827	29	1	282	1	COL13A1	10	71562459	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	296523	71562459	63972288	159	22711										
PLAU	5328	broad.mit.edu	37	chr10	75673458	75673459	+	Frame_Shift_Del	DEL	GT	GT	-													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gggggggctctgtcacctacGtgtgtggaggcagcctcatc							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:75673458_75673459delGT	uc001jwa.2	+	7	768_769	c.622_623delGT	c.(622-624)GTGfs	p.V208fs	C10orf55_uc001jvz.1_Intron|PLAU_uc010qkw.1_Frame_Shift_Del_p.V191fs|PLAU_uc010qkx.1_Frame_Shift_Del_p.V122fs|PLAU_uc001jwb.2_RNA|PLAU_uc001jwc.2_Frame_Shift_Del_p.V208fs|PLAU_uc009xrq.1_Frame_Shift_Del_p.V172fs	NM_002658	NP_002649	P00749	UROK_HUMAN	plasminogen activator, urokinase isoform 1	208	Peptidase S1.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(2)|kidney(1)	3	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	TGTCACCTACGTGTGTGGAGGC	0.599																		202	79	---	---								-	75673459	GT	-	75673458	7	5	74	1	0	1	0	1	0	0	0	0	12022	1145	40	0	682	0	PLAU	10	75673458	Frame_Shift_Del	DEL	GT	TCGA-FD-A3B6-01A-21D-A20D-08	4110999	75673458	59861289	160	22712										
KCNMA1	3778	broad.mit.edu	37	chr10	78729810	78729810	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tttttggtgatagtgttgacGgctgctcatcttcaactgga	11	7	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:78729810G>A	uc001jxn.2	-	20	2459	c.2282C>T	c.(2281-2283)CCG>CTG	p.P761L	KCNMA1_uc001jxj.2_Missense_Mutation_p.P707L|KCNMA1_uc001jxk.1_Missense_Mutation_p.P379L|KCNMA1_uc009xrt.1_Missense_Mutation_p.P552L|KCNMA1_uc001jxl.1_Missense_Mutation_p.P386L|KCNMA1_uc001jxo.2_Missense_Mutation_p.P703L|KCNMA1_uc001jxm.2_Missense_Mutation_p.P703L|KCNMA1_uc001jxq.2_Missense_Mutation_p.P706L	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	761	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TAGTGTTGACGGCTGCTCATC	0.483													0	0	0	0.014758	0	4	67										A	78729810	G	A	78729810	3	1	74	1	0	0	0	0	1	0	0	0	8073	1116	39	2	1620	2	KCNMA1	10	78729810	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3056352	78729810	56804937	161	22713										
BTAF1	9044	broad.mit.edu	37	chr10	93749199	93749199	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agtgcatagctaaactccttCagcagtgcacaacaaggacg	9	11	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:93749199C>A	uc001khr.2	+	20	2814	c.2716C>A	c.(2716-2718)CAG>AAG	p.Q906K	BTAF1_uc001khs.1_Missense_Mutation_p.Q576K|BTAF1_uc001kht.1_Missense_Mutation_p.Q344K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	906	HEAT 6.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TAAACTCCTTCAGCAGTGCAC	0.378													1	0	1.58986e-06	0.008291	1.67186e-06	9	41										A	93749199	C	A	93749199	3	1	74	1	0	0	0	0	1	0	0	0	1536	827	29	3	2794	3	BTAF1	10	93749199	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	15019389	93749199	41785548	162	22714										
C10orf76	79591	broad.mit.edu	37	chr10	103783474	103783474	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgttgatcattacatactcGagaatagtgttctggctgat	9	7	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:103783474G>A	uc009xwy.1	-	7	642	c.540C>T	c.(538-540)CTC>CTT	p.L180L		NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	180						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTACATACTCGAGAATAGTGT	0.383													0	0	0	0.012213	0	26	149										A	103783474	G	A	103783474	2	1	74	1	0	0	0	0	0	0	0	1	1616	1045	37	1		1	C10orf76	10	103783474	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	10034275	103783474	31751273	163	22715										
SORCS3	22986	broad.mit.edu	37	chr10	106737176	106737176	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acctatcagaagtatcggctCaccttctatatccagagcct	6	13	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr10:106737176C>T	uc001kyi.1	+	4	1106	c.879C>T	c.(877-879)CTC>CTT	p.L293L		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	293	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTATCGGCTCACCTTCTATA	0.443													0	0	0	0.007413	0	17	42										T	106737176	C	T	106737176	2	4	74	1	0	0	0	0	0	0	0	1	14932	813	29	1		1	SORCS3	10	106737176	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2953702	106737176	28797571	164	22716										
NRIP3	56675	broad.mit.edu	37	chr11	9009806	9009807	+	Missense_Mutation	DNP	CC	CC	AA													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aggttggtttccatgaggcgCctctgcagaatattatgagg							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:9009806_9009807CC>AA	uc001mhg.2	-	2	311_312	c.197_198GG>TT	c.(196-198)AGG>ATT	p.R66I	NRIP3_uc010rbu.1_Missense_Mutation_p.R66I	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	66					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		CCATGAGGCGCCTCTGCAGAAT	0.51													0	0	0	0.004672	0	17	56										AA	9009807	CC	AA	9009806	3	1	74	1	0	0	0	0	1	0	0	0	10654	738	26	4	551	4	NRIP3	11	9009806	Missense_Mutation	DNP	CC	TCGA-FD-A3B6-01A-21D-A20D-08		9009806	125996710	165	22717										
GTF2H1	2965	broad.mit.edu	37	chr11	18362845	18362845	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaaaatgttccccacaacatGacagagaaggaattctggac	9	9	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:18362845G>C	uc001moi.2	+	7	1339	c.645G>C	c.(643-645)ATG>ATC	p.M215I	GTF2H1_uc001moh.2_Missense_Mutation_p.M215I|GTF2H1_uc009yhm.2_Missense_Mutation_p.M99I	NM_001142307	NP_001135779	P32780	TF2H1_HUMAN	general transcription factor IIH, polypeptide 1,	215	BSD 2.				mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	protein binding				0						CCCACAACATGACAGAGAAGG	0.358								NER					0	0	0	0.01892	0	22	59										C	18362845	G	C	18362845	3	2	74	1	0	0	0	0	1	0	0	0	6860	1290	45	1	663	1	GTF2H1	11	18362845	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	9353039	18362845	116643671	166	22718										
NAV2	89797	broad.mit.edu	37	chr11	20089894	20089894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcaagctgcggcgggaactgGatgcctcccaggagaaagtt	15	10	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:20089894G>A	uc010rdm.1	+	24	5462	c.5101G>A	c.(5101-5103)GAT>AAT	p.D1701N	NAV2_uc001mpp.2_Missense_Mutation_p.D1581N|NAV2_uc001mpr.3_Missense_Mutation_p.D1645N|NAV2_uc001mpt.2_Missense_Mutation_p.D694N|NAV2_uc009yhx.2_Missense_Mutation_p.D709N|NAV2_uc009yhy.1_Missense_Mutation_p.D607N|NAV2_uc009yhz.2_Missense_Mutation_p.D290N|NAV2_uc001mpu.2_Missense_Mutation_p.D83N	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1701	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GCGGGAACTGGATGCCTCCCA	0.502													0	0	0	0.01441	0	63	127										A	20089894	G	A	20089894	3	1	74	1	0	0	0	0	1	0	0	0	10184	1174	41	1	5128	1	NAV2	11	20089894	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1727049	20089894	114916622	167	22719										
EXT2	2132	broad.mit.edu	37	chr11	44097105	44097105	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgaatggtggtgcctcgctCttctctgctctggccacggt	12	13	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:44097105C>G	uc010rfo.1	+	1	30	c.17C>G	c.(16-18)TCT>TGT	p.S6C	ACCS_uc010rfm.1_Silent_p.L100L|ACCS_uc009yks.1_Silent_p.L173L|ACCS_uc010rfn.1_Missense_Mutation_p.L150V|ACCS_uc001mxx.2_Silent_p.L173L	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GTGCCTCGCTCTTCTCTGCTC	0.602			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				0	0	0	0.024245	0	12	74										G	44097105	C	G	44097105	3	3	74	1	0	0	0	0	1	0	0	0	5324	900	32	1		1	EXT2	11	44097105	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	24007211	44097105	90909411	168	22720										
CKAP5	9793	broad.mit.edu	37	chr11	46783565	46783565	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcacatttccaatcagtttGaacacctgatccccatgtac	4	14	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:46783565G>A	uc001ndi.1	-	32	4316	c.4206C>T	c.(4204-4206)TTC>TTT	p.F1402F	CKAP5_uc009ylg.1_Silent_p.F1288F|CKAP5_uc001ndj.1_Silent_p.F1402F|CKAP5_uc001ndh.1_Silent_p.F331F	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1402					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CAATCAGTTTGAACACCTGAT	0.443													0	0	0	0.034045	0	26	100										A	46783565	G	A	46783565	2	1	74	1	0	0	0	0	0	0	0	1	3445	1281	45	1		1	CKAP5	11	46783565	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2686460	46783565	88222951	169	22721										
OR4C13	283092	broad.mit.edu	37	chr11	49974700	49974700	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tctacctgtgtctcccacatCacagttgtcatcttatcctt	4	14	5	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:49974700C>G	uc010rhz.1	+	1	726	c.726C>G	c.(724-726)ATC>ATG	p.I242M		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TCTCCCACATCACAGTTGTCA	0.463													0	0	0	0.01892	0	21	122										G	49974700	C	G	49974700	3	3	74	1	0	0	0	0	1	0	0	0	11047	816	29	1	728	1	OR4C13	11	49974700	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3191135	49974700	85031816	170	22722										
MARK2	2011	broad.mit.edu	37	chr11	63668461	63668461	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccatgggttatacacgggaaGagatccaggactcgctggtg	14	9	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:63668461G>T	uc001nxw.2	+	11	1600	c.1021G>T	c.(1021-1023)GAG>TAG	p.E341*	MARK2_uc001nxx.2_Nonsense_Mutation_p.E341*|MARK2_uc001nxy.2_Nonsense_Mutation_p.E341*|MARK2_uc001nxv.3_Nonsense_Mutation_p.E341*|MARK2_uc001nxz.3_Nonsense_Mutation_p.E308*|MARK2_uc009yoy.2_Nonsense_Mutation_p.E308*	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	341	UBA.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TACACGGGAAGAGATCCAGGA	0.577													1	0	1.08611e-07	0.010729	1.16892e-07	10	96										T	63668461	G	T	63668461	4	4	74	1	0	0	0	0	0	1	0	0	9313	943	33	3	1063	3	MARK2	11	63668461	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	13693761	63668461	71338055	171	22723										
SUV420H1	51111	broad.mit.edu	37	chr11	67957497	67957497	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tagacaacttgcctccatttCtcctgccattcaccaccatg	4	16	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:67957497C>G	uc001onm.1	-	2	303	c.47G>C	c.(46-48)AGA>ACA	p.R16T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_5'UTR|SUV420H1_uc009ysf.2_5'UTR|SUV420H1_uc001ono.1_Missense_Mutation_p.R16T|SUV420H1_uc001onp.2_Missense_Mutation_p.R16T|SUV420H1_uc010rqa.1_Missense_Mutation_p.R16T|SUV420H1_uc001onq.2_Missense_Mutation_p.R16T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	16					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GCCTCCATTTCTCCTGCCATT	0.478													0	0	0	0.01441	0	58	292										G	67957497	C	G	67957497	3	3	74	1	0	0	0	0	1	0	0	0	15411	913	32	1	2658	1	SUV420H1	11	67957497	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4289036	67957497	67049019	172	22724										
ARAP1	116985	broad.mit.edu	37	chr11	72418281	72418281	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcccagtcaggctgaggagcCccgcagtcagcacagaacct	12	15	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:72418281C>T	uc001osu.2	-	12	1851	c.1662G>A	c.(1660-1662)GGG>GGA	p.G554G	ARAP1_uc001osv.2_Silent_p.G554G|ARAP1_uc001osr.2_Silent_p.G314G|ARAP1_uc001oss.2_Silent_p.G309G|ARAP1_uc009yth.2_Silent_p.G309G|ARAP1_uc010rre.1_Silent_p.G309G	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	554	C4-type.|Arf-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GCTGAGGAGCCCCGCAGTCAG	0.647													0	0	0	0.00308	0	7	10										T	72418281	C	T	72418281	2	4	74	1	0	0	0	0	0	0	0	1	838	610	22	2		2	ARAP1	11	72418281	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4460784	72418281	62588235	173	22725										
THRSP	7069	broad.mit.edu	37	chr11	77775045	77775045	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tccccagccttctgcgggacGtgcagctgagtgggcctggg	16	13	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:77775045G>A	uc001oyx.2	+	1	139	c.118G>A	c.(118-120)GTG>ATG	p.V40M		NM_003251	NP_003242	Q92748	THRSP_HUMAN	thyroid hormone-responsive protein	40					lipid biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus				breast(1)	1	all_cancers(14;2.23e-19)|all_epithelial(13;7.49e-22)|Breast(9;6.38e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;2.15e-25)			TCTGCGGGACGTGCAGCTGAG	0.617													0	0	0	0.014323	0	21	110										A	77775045	G	A	77775045	3	1	74	1	0	0	0	0	1	0	0	0	15873	1145	40	2	120	2	THRSP	11	77775045	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5356764	77775045	57231471	174	22726										
PRCP	5547	broad.mit.edu	37	chr11	82560964	82560964	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	attaaagcttaccagtatttGagagtcgattaatggcatcc	8	7	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:82560964G>C	uc001ozs.2	-	5	856	c.743C>G	c.(742-744)TCA>TGA	p.S248*	PRCP_uc001ozr.2_Nonsense_Mutation_p.S269*	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	248	SKS domain.				blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						ACCAGTATTTGAGAGTCGATT	0.338													0	0	0	0.016723	0	9	99										C	82560964	G	C	82560964	4	2	74	1	0	0	0	0	0	1	0	0	12449	1294	45	1	767	1	PRCP	11	82560964	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4785919	82560964	52445552	175	22727										
CCDC81	60494	broad.mit.edu	37	chr11	86133623	86133623	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcctctcctcagggcttcaGacaagctgtttctcctagac	7	15	4	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:86133623G>A	uc001pbx.1	+	15	2253	c.1825G>A	c.(1825-1827)GAC>AAC	p.D609N	CCDC81_uc001pbw.1_Missense_Mutation_p.D519N|CCDC81_uc010rtq.1_Missense_Mutation_p.D392N|CCDC81_uc001pby.1_Missense_Mutation_p.D344N	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	609										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CAGGGCTTCAGACAAGCTGTT	0.562													0	0	0	0.013726	0	28	76										A	86133623	G	A	86133623	3	1	74	1	0	0	0	0	1	0	0	0	2855	942	33	1	1883	1	CCDC81	11	86133623	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3572659	86133623	48872893	176	22728										
FAT3	120114	broad.mit.edu	37	chr11	92616453	92616453	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccccgcatcctgacagcccgGcggggcgtggtcgtgtgcag	16	15	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:92616453G>A	uc001pdj.3	+	23	12848	c.12831G>A	c.(12829-12831)CGG>CGA	p.R4277R	FAT3_uc001pdi.3_Silent_p.R717R	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4277	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGACAGCCCGGCGGGGCGTGG	0.662										TCGA Ovarian(4;0.039)			0	0	0	0.012213	0	28	96										A	92616453	G	A	92616453	2	1	74	1	0	0	0	0	0	0	0	1	5691	1190	42	2		2	FAT3	11	92616453	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	6482830	92616453	42390063	177	22729										
KIAA1377	57562	broad.mit.edu	37	chr11	101857622	101857622	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tagtgaaagcatcagtgccgGaggatgagattctgactgtc	13	7	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:101857622G>T	uc001pgm.2	+	9	3364	c.3094G>T	c.(3094-3096)GAG>TAG	p.E1032*	KIAA1377_uc001pgn.2_Nonsense_Mutation_p.E988*|KIAA1377_uc010run.1_Nonsense_Mutation_p.E833*	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	1032							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		ATCAGTGCCGGAGGATGAGAT	0.363													1	0	8.73484e-25	0.01441	9.95555e-25	54	144										T	101857622	G	T	101857622	4	4	74	1	0	0	0	0	0	1	0	0	8227	1175	41	3	3128	3	KIAA1377	11	101857622	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	9241169	101857622	33148894	178	22730										
ALG9	79796	broad.mit.edu	37	chr11	111680410	111680410	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ataggccaagctgatccattCttctttattggatgaatatt	7	7	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:111680410C>G	uc001pmb.2	-	15	1768	c.1669G>C	c.(1669-1671)GAA>CAA	p.E557Q	ALG9_uc001ply.2_Missense_Mutation_p.E386Q|ALG9_uc001plz.2_Missense_Mutation_p.E393Q|ALG9_uc010rwm.1_Missense_Mutation_p.E564Q|ALG9_uc010rwn.1_Missense_Mutation_p.E511Q|ALG9_uc010rwo.1_Missense_Mutation_p.E385Q	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	557	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		CTGATCCATTCTTCTTTATTG	0.388													0	0	0	0.028581	0	14	70										G	111680410	C	G	111680410	3	3	74	1	0	0	0	0	1	0	0	0	524	922	32	1	174	1	ALG9	11	111680410	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	9822788	111680410	23326106	179	22731										
DSCAML1	57453	broad.mit.edu	37	chr11	117391942	117391942	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcttctgggccgaggtgatGagcagcgtctcgttgctgag	15	10	3	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:117391942G>T	uc001prh.1	-	6	1298	c.1296C>A	c.(1294-1296)CTC>CTA	p.L432L	DSCAML1_uc001pri.1_Silent_p.L236L	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	372	Extracellular (Potential).|Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCGAGGTGATGAGCAGCGTCT	0.637													1	0	2.27781e-18	0.01441	2.58011e-18	44	117										T	117391942	G	T	117391942	2	4	74	1	0	0	0	0	0	0	0	1	4769	1277	45	3		3	DSCAML1	11	117391942	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5711532	117391942	17614574	180	22732										
MLL	4297	broad.mit.edu	37	chr11	118374297	118374298	+	Frame_Shift_Ins	INS	-	-	CCTC													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcccacagaaccaatttcagINScctctgaaaatccaggagat							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			-	CCTC	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:118374297_118374298insCCTC	uc001pta.2	+	27	7704_7705	c.7681_7682insCCTC	c.(7681-7683)GCCfs	p.A2561fs	MLL_uc001ptb.2_Frame_Shift_Ins_p.A2564fs	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2561					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ACCAATTTCAGCCTCTGAAAAT	0.431			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL													20	60	---	---								CCTC	118374298	-	CCTC	118374297	7	5	74	1	0	1	1	0	0	0	0	0	9620	971	34	0	7787	0	MLL	11	118374297	Frame_Shift_Ins	INS	-	TCGA-FD-A3B6-01A-21D-A20D-08	982355	118374297	16632219	181	22733										
ETS1	2113	broad.mit.edu	37	chr11	128354930	128354930	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agctgggctctgagaactccGatggtggaacacactgggca	14	10	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:128354930G>A	uc010sbs.1	-	5	834	c.518C>T	c.(517-519)TCG>TTG	p.S173L	ETS1_uc001qej.2_Missense_Mutation_p.S217L|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.S173L	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	173					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		TGAGAACTCCGATGGTGGAAC	0.483													0	0	0	0.023175	0	29	179										A	128354930	G	A	128354930	3	1	74	1	0	0	0	0	1	0	0	0	5275	1059	37	1	823	1	ETS1	11	128354930	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	9980633	128354930	6651586	182	22734										
ARHGAP32	9743	broad.mit.edu	37	chr11	128842725	128842725	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	accaagataagaaggaggctGatctccactgtagaaacggg	12	8	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:128842725G>A	uc009zcp.2	-	21	3634	c.3634C>T	c.(3634-3636)CAG>TAG	p.Q1212*	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Nonsense_Mutation_p.Q171*|ARHGAP32_uc001qez.2_Nonsense_Mutation_p.Q863*	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1212					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GAAGGAGGCTGATCTCCACTG	0.453													0	0	0	0.0333	0	16	37										A	128842725	G	A	128842725	4	1	74	1	0	0	0	0	0	1	0	0	881	1299	45	1	2637	1	ARHGAP32	11	128842725	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	487795	128842725	6163791	183	22735										
IGSF9B	22997	broad.mit.edu	37	chr11	133814125	133814125	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgtcactcaccgttgatggtGaggtggacccagctgccatt	12	12	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:133814125G>A	uc001qgx.3	-	3	630	c.399C>T	c.(397-399)CTC>CTT	p.L133L	IGSF9B_uc001qgz.2_RNA	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	133	Extracellular (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CGTTGATGGTGAGGTGGACCC	0.602													0	0	0	0.006214	0	7	25										A	133814125	G	A	133814125	2	1	74	1	0	0	0	0	0	0	0	1	7606	1277	45	1		1	IGSF9B	11	133814125	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4971400	133814125	1192391	184	22736										
GLB1L3	112937	broad.mit.edu	37	chr11	134162074	134162074	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttctcttgacctctgatggtGagaaacatgtgctgagtggc	12	8	2	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr11:134162074G>A	uc009zdf.2	+	8	1138	c.778G>A	c.(778-780)GAG>AAG	p.E260K	GLB1L3_uc010scs.1_Missense_Mutation_p.E260K|GLB1L3_uc010sct.1_Missense_Mutation_p.E112K|GLB1L3_uc010scu.1_5'UTR	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	260					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CTCTGATGGTGAGAAACATGT	0.473													0	0	0	0.008871	0	15	26										A	134162074	G	A	134162074	3	1	74	1	0	0	0	0	1	0	0	0	6430	1291	45	1	808	1	GLB1L3	11	134162074	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	347949	134162074	844442	185	22737										
CACNA1C	775	broad.mit.edu	37	chr12	2676892	2676892	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	accatcctggtggagaccaaGatcatgtccccactgggcat	10	13	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:2676892G>C	uc009zdu.1	+	13	2140	c.1827G>C	c.(1825-1827)AAG>AAC	p.K609N	CACNA1C_uc009zdv.1_Missense_Mutation_p.K606N|CACNA1C_uc001qkb.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkc.2_Missense_Mutation_p.K609N|CACNA1C_uc001qke.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkf.2_Missense_Mutation_p.K609N|CACNA1C_uc001qjz.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkd.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkg.2_Missense_Mutation_p.K609N|CACNA1C_uc009zdw.1_Missense_Mutation_p.K609N|CACNA1C_uc001qkh.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkl.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkn.2_Missense_Mutation_p.K609N|CACNA1C_uc001qko.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkp.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkr.2_Missense_Mutation_p.K609N|CACNA1C_uc001qku.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkq.2_Missense_Mutation_p.K609N|CACNA1C_uc001qks.2_Missense_Mutation_p.K609N|CACNA1C_uc001qkt.2_Missense_Mutation_p.K609N|CACNA1C_uc001qka.1_Missense_Mutation_p.K144N|CACNA1C_uc001qki.1_Missense_Mutation_p.K345N|CACNA1C_uc001qkj.1_Missense_Mutation_p.K345N|CACNA1C_uc001qkk.1_Missense_Mutation_p.K345N|CACNA1C_uc001qkm.1_Missense_Mutation_p.K345N	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	609	II.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TGGAGACCAAGATCATGTCCC	0.587													0	0	0	0.009096	0	4	39										C	2676892	G	C	2676892	3	2	74	1	0	0	0	0	1	0	0	0	2540	933	33	1	1985	1	CACNA1C	12	2676892	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		2676892	131175003	186	22738										
GNB3	2784	broad.mit.edu	37	chr12	6952355	6952355	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caggctgctggtaagtgcctCgcaagatgggaagctgatcg	15	9	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:6952355C>T	uc001qrd.2	+	6	626	c.221C>T	c.(220-222)TCG>TTG	p.S74L	GNB3_uc001qrc.2_Missense_Mutation_p.S30L|GNB3_uc009zfe.2_Missense_Mutation_p.S74L	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	74	WD 1.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GTAAGTGCCTCGCAAGATGGG	0.612													0	0	0	0.023175	0	33	219										T	6952355	C	T	6952355	3	4	74	1	0	0	0	0	1	0	0	0	6519	893	31	1	235	1	GNB3	12	6952355	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4275463	6952355	126899540	187	22739										
SLC2A3	6515	broad.mit.edu	37	chr12	8078455	8078455	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttacagaaactacagtgaaGatagtattaaccacacccgc	6	11	0	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:8078455G>C	uc001qtr.2	-	7	1213	c.951C>G	c.(949-951)ATC>ATG	p.I317M		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	317	Helical; Name=8; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		CTACAGTGAAGATAGTATTAA	0.433													0	0	0	0.008871	0	16	163										C	8078455	G	C	8078455	3	2	74	1	0	0	0	0	1	0	0	0	14545	932	33	1	555	1	SLC2A3	12	8078455	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1126100	8078455	125773440	188	22740										
ABCC9	10060	broad.mit.edu	37	chr12	22068679	22068679	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tattggcaattttccaattgCcttcagatcaataggctttt	6	8	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:22068679C>A	uc001rfi.1	-	5	759	c.739G>T	c.(739-741)GCA>TCA	p.A247S	ABCC9_uc001rfh.2_Missense_Mutation_p.A247S|ABCC9_uc001rfj.1_Missense_Mutation_p.A247S	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	247	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTCCAATTGCCTTCAGATCA	0.363													1	0	9.24413e-38	0.01441	1.07361e-37	92	72										A	22068679	C	A	22068679	3	1	74	1	0	0	0	0	1	0	0	0	59	739	26	4	4188	4	ABCC9	12	22068679	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	13990224	22068679	111783216	189	22741										
FGD4	121512	broad.mit.edu	37	chr12	32729320	32729320	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aattaaacctgcctctgcttCttgtgtctcaaaagaaaaac	5	10	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:32729320C>G	uc001rkz.2	+	3	506	c.29C>G	c.(28-30)TCT>TGT	p.S10C	FGD4_uc001rlc.2_Missense_Mutation_p.S95C|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.S122C|FGD4_uc001rkx.3_Missense_Mutation_p.S10C	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	10	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					GCCTCTGCTTCTTGTGTCTCA	0.443													0	0	0	0.014323	0	18	68										G	32729320	C	G	32729320	3	3	74	1	0	0	0	0	1	0	0	0	5835	913	32	1	31	1	FGD4	12	32729320	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10660641	32729320	101122575	190	22742										
DNM1L	10059	broad.mit.edu	37	chr12	32861134	32861135	+	Frame_Shift_Del	DEL	AG	AG	-													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caagaaattgaaaatgaaacAgaaagaatttcaggaaataa							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:32861134_32861135delAG	uc001rld.2	+	4	506_507	c.345_346delAG	c.(343-348)ACAGAAfs	p.T115fs	DNM1L_uc010skf.1_RNA|DNM1L_uc010skg.1_RNA|DNM1L_uc001rle.2_Frame_Shift_Del_p.T115fs|DNM1L_uc001rlf.2_Frame_Shift_Del_p.T115fs|DNM1L_uc010skh.1_Frame_Shift_Del_p.T181fs|DNM1L_uc001rlg.2_Frame_Shift_Del_p.T181fs|DNM1L_uc001rlh.2_Frame_Shift_Del_p.T168fs|DNM1L_uc010ski.1_Intron	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	115_116	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AAAATGAAACAGAAAGAATTTC	0.262																		45	49	---	---								-	32861135	AG	-	32861134	7	5	74	1	0	1	0	1	0	0	0	0	4671	175	7	0	359	0	DNM1L	12	32861134	Frame_Shift_Del	DEL	AG	TCGA-FD-A3B6-01A-21D-A20D-08	131814	32861134	100990761	191	22743										
ADAMTS20	80070	broad.mit.edu	37	chr12	43750291	43750291	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtcccgcaggacttacctctGatcttcgtatgctgacagag	10	12	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:43750291G>A	uc010skx.1	-	38	5639	c.5639C>T	c.(5638-5640)TCA>TTA	p.S1880L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1880	GON.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACTTACCTCTGATCTTCGTAT	0.408													0	0	0	0.021553	0	5	9										A	43750291	G	A	43750291	3	1	74	1	0	0	0	0	1	0	0	0	266	1294	45	1	100	1	ADAMTS20	12	43750291	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	10889157	43750291	90101604	192	22744										
ADAMTS20	80070	broad.mit.edu	37	chr12	43822323	43822323	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gttgtttttccatggccacaGgaagctgaacactgatcaaa	9	9	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:43822323G>A	uc010skx.1	-	26	3666	c.3666C>T	c.(3664-3666)TCC>TCT	p.S1222S	ADAMTS20_uc001rno.1_Silent_p.S340S|ADAMTS20_uc001rnp.1_Silent_p.S376S	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1222	TSP type-1 8.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CATGGCCACAGGAAGCTGAAC	0.308													0	0	0	0.00308	0	7	15										A	43822323	G	A	43822323	2	1	74	1	0	0	0	0	0	0	0	1	266	987	35	2		2	ADAMTS20	12	43822323	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	72032	43822323	90029572	193	22745										
SENP1	29843	broad.mit.edu	37	chr12	48482596	48482596	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atacgaaccttgaggtctttCgggtttcgaggtaaagactt	11	7	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:48482596C>T	uc001rqx.2	-	5	814	c.368G>A	c.(367-369)CGA>CAA	p.R123Q	SENP1_uc001rqw.2_Missense_Mutation_p.R123Q|SENP1_uc001rqy.2_5'UTR|SENP1_uc001rqz.2_5'UTR|SENP1_uc009zkx.2_Missense_Mutation_p.R123Q	NM_014554	NP_055369	Q9P0U3	SENP1_HUMAN	sentrin/SUMO-specific protease 1	123	Ser-rich.				activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			pancreas(2)|lung(1)	3		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				TGAGGTCTTTCGGGTTTCGAG	0.403													0	0	0	0.02938	0	5	6										T	48482596	C	T	48482596	3	4	74	1	0	0	0	0	1	0	0	0	14046	884	31	1	1619	1	SENP1	12	48482596	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4660273	48482596	85369299	194	22746										
METTL7A	25840	broad.mit.edu	37	chr12	51319031	51319031	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gagtttgcgggcccctccggGaaactctccctgctggaagt	13	13	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:51319031G>A	uc001rxb.2	+	1	498	c.210G>A	c.(208-210)GGG>GGA	p.G70G	METTL7A_uc010smv.1_Silent_p.G70G	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	70						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						GCCCCTCCGGGAAACTCTCCC	0.562													0	0	0	0.014758	0	4	24										A	51319031	G	A	51319031	2	1	74	1	0	0	0	0	0	0	0	1	9505	1161	41	1		1	METTL7A	12	51319031	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2836435	51319031	82532864	195	22747										
METTL7A	25840	broad.mit.edu	37	chr12	51319142	51319142	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cccaactttgagaagtttttGatcaagagcattgcagagaa	9	7	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:51319142G>A	uc001rxb.2	+	1	609	c.321G>A	c.(319-321)TTG>TTA	p.L107L	METTL7A_uc010smv.1_Intron	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	107						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						AGAAGTTTTTGATCAAGAGCA	0.557													0	0	0	0.013537	0	11	44										A	51319142	G	A	51319142	2	1	74	1	0	0	0	0	0	0	0	1	9505	1281	45	1		1	METTL7A	12	51319142	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	111	51319142	82532753	196	22748										
ZNF740	283337	broad.mit.edu	37	chr12	53579200	53579200	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aaagacagtgataagtcccgGagccgcaaagatgatgacag	12	8	0	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:53579200G>A	uc001scb.3	+	4	583	c.189G>A	c.(187-189)CGG>CGA	p.R63R		NM_001004304	NP_001004304	Q8NDX6	ZN740_HUMAN	zinc finger protein 740	63					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|protein binding|zinc ion binding				0						ATAAGTCCCGGAGCCGCAAAG	0.453													0	0	0	0.013537	0	10	22										A	53579200	G	A	53579200	2	1	74	1	0	0	0	0	0	0	0	1	18125	1161	41	1		1	ZNF740	12	53579200	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2260058	53579200	80272695	197	22749										
ERBB3	2065	broad.mit.edu	37	chr12	56482341	56482341	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccctagataactttgtggtgGatcaaacatcctgtgtcagg	10	9	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:56482341G>T	uc001sjh.2	+	8	1082	c.889G>T	c.(889-891)GAT>TAT	p.D297Y	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.D238Y|ERBB3_uc001sji.2_5'UTR	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	297	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTTTGTGGTGGATCAAACATC	0.512													1	0	4.0181e-32	0.01441	4.65187e-32	41	169										T	56482341	G	T	56482341	3	4	74	1	0	0	0	0	1	0	0	0	5208	1174	41	3	1050	3	ERBB3	12	56482341	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2903141	56482341	77369554	198	22750										
CS	1431	broad.mit.edu	37	chr12	56667506	56667506	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gggtcattaggcaggtgtttCagagcaaactctcgctgaca	12	9	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:56667506C>T	uc001sks.1	-	10	1285	c.1095G>A	c.(1093-1095)CTG>CTA	p.L365L	CS_uc010sql.1_Silent_p.L352L|CS_uc001skr.1_Silent_p.L299L|CS_uc001skt.1_Silent_p.L320L|CS_uc010sqm.1_3'UTR	NM_004077	NP_004068	O75390	CISY_HUMAN	citrate synthase precursor	365					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity				0		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		GCAGGTGTTTCAGAGCAAACT	0.468													0	0	0	0.009535	0	25	86										T	56667506	C	T	56667506	2	4	74	1	0	0	0	0	0	0	0	1	3924	813	29	1		1	CS	12	56667506	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	185165	56667506	77184389	199	22751										
GLIPR1	11010	broad.mit.edu	37	chr12	75875733	75875733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aacttcacttcactgggagaGaacatctggactgggtctgt	11	9	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:75875733G>C	uc001sxs.2	+	2	442	c.294G>C	c.(292-294)GAG>GAC	p.E98D	GLIPR1_uc009zsb.1_Missense_Mutation_p.E98D	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	98					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						CACTGGGAGAGAACATCTGGA	0.483													0	0	0	0.01892	0	19	78										C	75875733	G	C	75875733	3	2	74	1	0	0	0	0	1	0	0	0	6441	933	33	1	300	1	GLIPR1	12	75875733	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	19208227	75875733	57976162	200	22752										
NAV3	89795	broad.mit.edu	37	chr12	78513485	78513485	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttccaacgtcagcagcaagtCtgctggggccaccacctcga	10	15	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:78513485C>G	uc001syp.2	+	15	3682	c.3509C>G	c.(3508-3510)TCT>TGT	p.S1170C	NAV3_uc001syo.2_Missense_Mutation_p.S1170C|NAV3_uc010sub.1_Missense_Mutation_p.S670C|NAV3_uc009zsf.2_Missense_Mutation_p.S178C	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1170	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGCAGCAAGTCTGCTGGGGCC	0.537										HNSCC(70;0.22)			0	0	0	0.004482	0	8	41										G	78513485	C	G	78513485	3	3	74	1	0	0	0	0	1	0	0	0	10185	913	32	1	3567	1	NAV3	12	78513485	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2637752	78513485	55338410	201	22753										
ACSS3	79611	broad.mit.edu	37	chr12	81503360	81503360	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tttgtggaaggaatgcttaaCatttgttacaatgccgttga	10	5	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:81503360C>T	uc001szl.1	+	2	424	c.333C>T	c.(331-333)AAC>AAT	p.N111N	ACSS3_uc001szm.1_Silent_p.N110N	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	111						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GAATGCTTAACATTTGTTACA	0.313													0	0	0	0.006214	0	7	61										T	81503360	C	T	81503360	2	4	74	1	0	0	0	0	0	0	0	1	190	477	17	2		2	ACSS3	12	81503360	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2989875	81503360	52348535	202	22754										
TMTC3	160418	broad.mit.edu	37	chr12	88584258	88584258	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tggtaaaaaatatgcagccaGaattgcccctaaccacctaa	6	11	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:88584258G>A	uc001tau.2	+	12	1785	c.1565G>A	c.(1564-1566)AGA>AAA	p.R522K		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	522						integral to membrane	binding			skin(1)	1						TATGCAGCCAGAATTGCCCCT	0.373													0	0	0	0.028581	0	11	68										A	88584258	G	A	88584258	3	1	74	1	0	0	0	0	1	0	0	0	16259	942	33	1	1607	1	TMTC3	12	88584258	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	7080898	88584258	45267637	203	22755										
MTERFD3	80298	broad.mit.edu	37	chr12	107372423	107372423	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	taagaaaggtctgtattttgGaggtgatcgcatctttctga	11	5	3	3	rs139694986	byFrequency	TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:107372423G>C	uc001tme.1	-	2	1889	c.70C>G	c.(70-72)CCA>GCA	p.P24A	MTERFD3_uc001tmf.1_Missense_Mutation_p.P24A|MTERFD3_uc001tmg.1_Missense_Mutation_p.P24A|MTERFD3_uc001tmh.1_Missense_Mutation_p.P24A	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						CTGTATTTTGGAGGTGATCGC	0.433													0	0	0	0.021553	0	6	47										C	107372423	G	C	107372423	3	2	74	1	0	0	0	0	1	0	0	0	9921	1174	41	1	1091	1	MTERFD3	12	107372423	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	18788165	107372423	26479472	204	22756										
ACACB	32	broad.mit.edu	37	chr12	109702924	109702924	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcgtccacaggacatcctgGagtggaagaccgcacgcacc	11	15	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:109702924G>C	uc001tob.2	+	51	7071	c.6952G>C	c.(6952-6954)GAG>CAG	p.E2318Q	ACACB_uc001toc.2_Missense_Mutation_p.E2318Q|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.E984Q	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2318					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGACATCCTGGAGTGGAAGAC	0.647													0	0	0	0.01441	0	51	131										C	109702924	G	C	109702924	3	2	74	1	0	0	0	0	1	0	0	0	107	1175	41	1	7150	1	ACACB	12	109702924	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2330501	109702924	24148971	205	22757										
GCN1L1	10985	broad.mit.edu	37	chr12	120576588	120576588	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaaagtcttggctgccgcctCtctgacctcctccagtgggt	11	14	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:120576588C>T	uc001txo.2	-	46	6080	c.6067G>A	c.(6067-6069)GAG>AAG	p.E2023K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2023	HEAT 17.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGCCGCCTCTCTGACCTCC	0.547													0	0	0	0.01441	0	63	151										T	120576588	C	T	120576588	3	4	74	1	0	0	0	0	1	0	0	0	6299	922	32	1	2000	1	GCN1L1	12	120576588	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10873664	120576588	13275307	206	22758										
RILPL1	353116	broad.mit.edu	37	chr12	123970241	123970241	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggacttgagctcgttcctctCgtgcagcacgtcccgcagct	11	15	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:123970241C>T	uc001ufe.2	-	5	1149	c.913G>A	c.(913-915)GAG>AAG	p.E305K	RILPL1_uc001ufd.2_Missense_Mutation_p.E154K|RILPL1_uc010tas.1_Missense_Mutation_p.E305K	NM_178314	NP_847884	Q5EBL4	RIPL1_HUMAN	Rab interacting lysosomal protein-like 1	305	RILP-like.				neuroprotection	cytosol					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		TCGTTCCTCTCGTGCAGCACG	0.622													0	0	0	0.004482	0	6	47										T	123970241	C	T	123970241	3	4	74	1	0	0	0	0	1	0	0	0	13361	893	31	1	310	1	RILPL1	12	123970241	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3393653	123970241	9881654	207	22759										
TMEM132B	114795	broad.mit.edu	37	chr12	125834138	125834138	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aagacctcacaaggaactccAgtctgcaggcccgggtggag	13	12	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:125834138A>G	uc001uhe.1	+	2	201	c.193A>G	c.(193-195)AGT>GGT	p.S65G		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	65	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGGAACTCCAGTCTGCAGGC	0.522													0	0	0	0.037714	0	22	137										G	125834138	A	G	125834138	3	3	74	1	0	0	0	0	1	0	0	0	16043	188	7	5	199	5	TMEM132B	12	125834138	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	1863897	125834138	8017757	208	22760										
POLE	5426	broad.mit.edu	37	chr12	133252767	133252767	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcaatatcttctgaaacaatCtccctgttggtgatgaggta	8	8	4	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:133252767C>G	uc001uks.1	-	10	977	c.933G>C	c.(931-933)GAG>GAC	p.E311D	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.E284D	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	311					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTGAAACAATCTCCCTGTTGG	0.478								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.004482	0	7	68										G	133252767	C	G	133252767	3	3	74	1	0	0	0	0	1	0	0	0	12196	912	32	1	6087	1	POLE	12	133252767	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7418629	133252767	599128	209	22761										
CHFR	55743	broad.mit.edu	37	chr12	133433181	133433181	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agtgattttatttctggcatCcatactttgcacatcttctt	5	9	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr12:133433181C>G	uc001ulf.2	-	10	1222	c.1138G>C	c.(1138-1140)GAT>CAT	p.D380H	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.D368H|CHFR_uc010tbs.1_Missense_Mutation_p.D380H|CHFR_uc001uld.2_Missense_Mutation_p.D339H|CHFR_uc010tbt.1_Missense_Mutation_p.D288H	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	380					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TTTCTGGCATCCATACTTTGC	0.493													0	0	0	0.01441	0	61	199										G	133433181	C	G	133433181	3	3	74	1	0	0	0	0	1	0	0	0	3337	855	30	1	892	1	CHFR	12	133433181	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	180414	133433181	418714	210	22762										
IFT88	8100	broad.mit.edu	37	chr13	21212522	21212522	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cagatatagctgtgaactctGatagatataatccagcagct	8	8	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:21212522G>C	uc001unh.2	+	19	1861	c.1465G>C	c.(1465-1467)GAT>CAT	p.D489H	IFT88_uc001uni.2_Missense_Mutation_p.D480H|IFT88_uc001unj.2_Missense_Mutation_p.D479H|IFT88_uc010tcq.1_Missense_Mutation_p.D460H|IFT88_uc001unk.2_Missense_Mutation_p.D235H	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	489	TPR 6.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TGTGAACTCTGATAGATATAA	0.338													0	0	0	0.020292	0	10	108										C	21212522	G	C	21212522	3	2	74	1	0	0	0	0	1	0	0	0	7566	1290	45	1	1531	1	IFT88	13	21212522	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		21212522	93957356	211	22763										
FRY	10129	broad.mit.edu	37	chr13	32841395	32841395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttcagcccgcagcctgtgacGatgccgaggaggcctggcgc	15	14	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:32841395G>A	uc001utx.2	+	55	8531	c.8035G>A	c.(8035-8037)GAT>AAT	p.D2679N	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_Missense_Mutation_p.D234N|FRY_uc001utz.2_Missense_Mutation_p.D204N|FRY_uc010tdx.1_Missense_Mutation_p.D49N	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2679					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGCCTGTGACGATGCCGAGGA	0.547													0	0	0	0.01892	0	25	118										A	32841395	G	A	32841395	3	1	74	1	0	0	0	0	1	0	0	0	6063	1058	37	1	8253	1	FRY	13	32841395	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	11628873	32841395	82328483	212	22764										
MED4	29079	broad.mit.edu	37	chr13	48660459	48660459	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tagctgtttttgtagctgctGaatatcactgtctctcttct	7	9	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:48660459G>A	uc001vby.1	-	3	348	c.322C>T	c.(322-324)CAG>TAG	p.Q108*	MED4_uc010tge.1_Nonsense_Mutation_p.Q108*|MED4_uc010tgf.1_Nonsense_Mutation_p.Q62*	NM_014166	NP_054885	Q9NPJ6	MED4_HUMAN	mediator complex subunit 4	108	Potential.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		all_cancers(8;2.93e-25)|all_epithelial(8;4.38e-13)|all_lung(13;7.37e-06)|all_hematologic(8;8.61e-05)|Breast(56;0.000141)|Lung NSC(96;0.000518)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.00559)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;5.18e-07)		TGTAGCTGCTGAATATCACTG	0.338													0	0	0	0.012319	0	18	99										A	48660459	G	A	48660459	4	1	74	1	0	0	0	0	0	1	0	0	9450	1299	45	1	510	1	MED4	13	48660459	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	15819064	48660459	66509419	213	22765										
RB1	5925	broad.mit.edu	37	chr13	49027133	49027133	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atcatgtttcatataggattCacctttatttgatcttatta	4	6	4	1	rs137853292		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:49027133C>T	uc001vcb.2	+	18	1866	c.1700C>T	c.(1699-1701)TCA>TTA	p.S567L		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	567	Domain A.|Pocket; binds T and E1A.		S -> L (in RB).		androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.S567*(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATATAGGATTCACCTTTATTT	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.0333	0	16	34										T	49027133	C	T	49027133	3	4	74	1	0	0	0	0	1	0	0	0	13098	838	29	1	1770	1	RB1	13	49027133	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	366674	49027133	66142745	214	22766										
RB1	5925	broad.mit.edu	37	chr13	49027219	49027219	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttgtcctcttaatcttcctCtccagaataatcacactgca	3	14	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:49027219C>G	uc001vcb.2	+	18	1952	c.1786C>G	c.(1786-1788)CTC>GTC	p.L596V		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	596	Pocket; binds T and E1A.|Spacer.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAATCTTCCTCTCCAGAATAA	0.338		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.010818	0	27	50										G	49027219	C	G	49027219	3	3	74	1	0	0	0	0	1	0	0	0	13098	913	32	1	1856	1	RB1	13	49027219	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	86	49027219	66142659	215	22767										
OLFM4	10562	broad.mit.edu	37	chr13	53602986	53602986	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gacaagatgaggcccggcctCtcatttctcctagcccttct	8	15	3	2	rs149259735		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:53602986C>T	uc001vhl.2	+	1	15	c.15C>T	c.(13-15)CTC>CTT	p.L5L	OLFM4_uc001vhk.1_Silent_p.L5L	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	5					cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GGCCCGGCCTCTCATTTCTCC	0.592													0	0	0	0.01441	0	56	121										T	53602986	C	T	53602986	2	4	74	1	0	0	0	0	0	0	0	1	10855	900	32	1		1	OLFM4	13	53602986	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4575767	53602986	61566892	216	22768										
MYCBP2	23077	broad.mit.edu	37	chr13	77786175	77786175	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atcaattcgtaaaaaagtttGgtccccacttgcacctatcc	5	12	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr13:77786175G>T	uc001vkf.2	-	23	3155	c.3064C>A	c.(3064-3066)CAA>AAA	p.Q1022K	MYCBP2_uc010aev.2_Missense_Mutation_p.Q426K	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1022	RCC1 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AAAAAAGTTTGGTCCCCACTT	0.358													1	0	0.000602214	0.014758	0.000617354	5	57										T	77786175	G	T	77786175	3	4	74	1	0	0	0	0	1	0	0	0	10018	1357	47	4	11106	4	MYCBP2	13	77786175	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	24183189	77786175	37383703	217	22769										
ADCY4	196883	broad.mit.edu	37	chr14	24801042	24801042	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cggcgtgagtgcagggagctGagtgcctcccggaacgtggc	18	11	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:24801042G>T	uc001wov.2	-	4	627	c.621C>A	c.(619-621)CTC>CTA	p.L207L	ADCY4_uc001wow.2_Silent_p.L207L|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Silent_p.L207L|ADCY4_uc001woy.2_Silent_p.L207L	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	207	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GCAGGGAGCTGAGTGCCTCCC	0.567													1	0	5.9392e-07	0.021553	6.31793e-07	4	30										T	24801042	G	T	24801042	2	4	74	1	0	0	0	0	0	0	0	1	296	1277	45	3		3	ADCY4	14	24801042	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		24801042	82548498	218	22770										
NFKBIA	4792	broad.mit.edu	37	chr14	35873730	35873730	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttgaccatctgctcgtactCctcgtctttcatggagtcca	7	14	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:35873730C>T	uc001wtf.3	-	1	231	c.121G>A	c.(121-123)GAG>AAG	p.E41K	NFKBIA_uc001wte.3_5'Flank|NFKBIA_uc001wtg.3_Missense_Mutation_p.E41K|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	41					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		TGCTCGTACTCCTCGTCTTTC	0.687													0	0	0	0.021553	0	6	16										T	35873730	C	T	35873730	3	4	74	1	0	0	0	0	1	0	0	0	10377	864	30	1	856	1	NFKBIA	14	35873730	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	11072688	35873730	71475810	219	22771										
TXNDC16	57544	broad.mit.edu	37	chr14	52922155	52922155	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tctggcaagcagcagggctgGaagacttgcagcatatttgg	14	8	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:52922155G>A	uc001wzs.2	-	18	2178	c.1729C>T	c.(1729-1731)CCA>TCA	p.P577S	TXNDC16_uc010tqu.1_Missense_Mutation_p.P572S|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	577					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					AGCAGGGCTGGAAGACTTGCA	0.418													0	0	0	0.01441	0	57	54										A	52922155	G	A	52922155	3	1	74	1	0	0	0	0	1	0	0	0	16792	1174	41	1	764	1	TXNDC16	14	52922155	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	17048425	52922155	54427385	220	22772										
DLGAP5	9787	broad.mit.edu	37	chr14	55618599	55618599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgctactccaccagcaagaaGaggcaaactcattctctcac	6	14	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:55618599G>C	uc001xbs.2	-	17	2399	c.2182C>G	c.(2182-2184)CTT>GTT	p.L728V	DLGAP5_uc001xbt.2_Missense_Mutation_p.L728V	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	728					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						CCAGCAAGAAGAGGCAAACTC	0.328													0	0	0	0.011902	0	43	43										C	55618599	G	C	55618599	3	2	74	1	0	0	0	0	1	0	0	0	4563	942	33	1	465	1	DLGAP5	14	55618599	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2696444	55618599	51730941	221	22773										
DAAM1	23002	broad.mit.edu	37	chr14	59835468	59835468	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgtttcagctttacgctcagGagaagtgtttgacaaagacc	10	8	2	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:59835468G>T	uc001xdz.1	+	26	3253	c.3128G>T	c.(3127-3129)GGA>GTA	p.G1043V	DAAM1_uc001xea.1_Missense_Mutation_p.G1033V|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	1043	DAD.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TTACGCTCAGGAGAAGTGTTT	0.403													1	0	2.54651e-27	0.027894	2.92968e-27	38	27										T	59835468	G	T	59835468	3	4	74	1	0	0	0	0	1	0	0	0	4215	1174	41	3	3226	3	DAAM1	14	59835468	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4216869	59835468	47514072	222	22774										
BEGAIN	57596	broad.mit.edu	37	chr14	101005271	101005273	+	In_Frame_Del	DEL	CCT	CCT	-													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgggaaggccgccgcctcggCctcctcctcctcctcggccg							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr14:101005271_101005273delCCT	uc010txa.1	-	6	961_963	c.815_817delAGG	c.(814-819)GAGGCC>GCC	p.E272del	BEGAIN_uc001yhp.2_In_Frame_Del_p.E208del|BEGAIN_uc001yhq.2_In_Frame_Del_p.E272del	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	272						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				GCCGCCTCGGCCTCCTCCTCCTC	0.724																		7	18	---	---								-	101005273	CCT	-	101005271	7	5	74	1	0	1	0	1	0	0	0	0	1397	739	26	0	968	0	BEGAIN	14	101005271	In_Frame_Del	DEL	CCT	TCGA-FD-A3B6-01A-21D-A20D-08	41169803	101005271	6344269	223	22775										
MTMR10	54893	broad.mit.edu	37	chr15	31233969	31233969	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agccaggagggagagcttgtGaaaggctgtgatggagccac	17	7	0	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:31233969G>A	uc001zfh.1	-	16	2136	c.2038C>T	c.(2038-2040)CAC>TAC	p.H680Y	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Missense_Mutation_p.H94Y|MTMR10_uc001zfg.1_Missense_Mutation_p.H261Y|MTMR10_uc010azx.1_Missense_Mutation_p.H432Y|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	680							phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		GAGAGCTTGTGAAAGGCTGTG	0.602													0	0	0	0.028581	0	14	19										A	31233969	G	A	31233969	3	1	74	1	0	0	0	0	1	0	0	0	9939	1290	45	1	299	1	MTMR10	15	31233969	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		31233969	71297423	224	22776										
STRC	161497	broad.mit.edu	37	chr15	43910137	43910137	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cagacggcccatcacgggtgCatgggggccgagttggggta	18	10	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:43910137C>T	uc001zsf.2	-	2	560	c.482G>A	c.(481-483)TGC>TAC	p.C161Y	STRC_uc010bdl.2_5'UTR|STRC_uc010udz.1_RNA|STRC_uc001zsg.1_Missense_Mutation_p.C87Y	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	161					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ATCACGGGTGCATGGGGGCCG	0.637													0	0	0	0.007413	0	13	122										T	43910137	C	T	43910137	3	4	74	1	0	0	0	0	1	0	0	0	15327	710	25	2	4957	2	STRC	15	43910137	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	12676168	43910137	58621255	225	22777										
SEMA6D	80031	broad.mit.edu	37	chr15	48052505	48052505	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccatttttacttgcagattcAaggcaatatccggtttttag	7	8	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:48052505A>T	uc010bek.2	+	3	474	c.114A>T	c.(112-114)TCA>TCT	p.S38S	SEMA6D_uc001zvw.2_Silent_p.S38S|SEMA6D_uc001zvx.1_Silent_p.S38S|SEMA6D_uc001zvy.2_Silent_p.S38S|SEMA6D_uc001zvz.2_Silent_p.S38S|SEMA6D_uc001zwa.2_Silent_p.S38S|SEMA6D_uc001zwb.2_Silent_p.S38S|SEMA6D_uc001zwc.2_Silent_p.S38S	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	38	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTGCAGATTCAAGGCAATATC	0.413													0	0	0	0.010729	0	11	54										T	48052505	A	T	48052505	2	4	74	1	0	0	0	0	0	0	0	1	14042	117	5	5		5	SEMA6D	15	48052505	Silent	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	4142368	48052505	54478887	226	22778										
ITGA11	22801	broad.mit.edu	37	chr15	68649637	68649637	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gccatactgcacaactccaaCctgcaagggagaggagaggg	13	11	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:68649637C>A	uc002ari.2	-	7	688	c.601G>T	c.(601-603)GTT>TTT	p.V201F	ITGA11_uc010bib.2_Missense_Mutation_p.V201F	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	201	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	ACAACTCCAACCTGCAAGGGA	0.498													1	0	2.27525e-19	0.021523	2.5852e-19	17	76										A	68649637	C	A	68649637	3	1	74	1	0	0	0	0	1	0	0	0	7874	521	18	4	3061	4	ITGA11	15	68649637	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	20597132	68649637	33881755	227	22779										
PTPN9	5780	broad.mit.edu	37	chr15	75819584	75819584	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgtccacttgttaatctcttCgagaaactgcttggtagcct	8	10	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:75819584C>T	uc002bal.2	-	2	590	c.82G>A	c.(82-84)GAA>AAA	p.E28K		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	28						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						TTAATCTCTTCGAGAAACTGC	0.398													0	0	0	0.02938	0	6	63										T	75819584	C	T	75819584	3	4	74	1	0	0	0	0	1	0	0	0	12794	893	31	1	1747	1	PTPN9	15	75819584	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7169947	75819584	26711808	228	22780										
SGK269	79834	broad.mit.edu	37	chr15	77472021	77472021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gctgcccaccatctgagactCctgagtgccttctattttgg	9	13	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:77472021C>T	uc002bcm.2	-	3	2556	c.2248G>A	c.(2248-2250)GAG>AAG	p.E750K	SGK269_uc002bcn.2_Missense_Mutation_p.E750K	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	750					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		ATCTGAGACTCCTGAGTGCCT	0.527													0	0	0	0.006214	0	8	77										T	77472021	C	T	77472021	3	4	74	1	0	0	0	0	1	0	0	0	14211	864	30	1	3008	1	SGK269	15	77472021	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1652437	77472021	25059371	229	22781										
TM6SF1	53346	broad.mit.edu	37	chr15	83776476	83776476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggtcttcgtgctgtccctctCggccatcccggtcacctatg	10	16	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr15:83776476C>T	uc002bjp.2	+	1	153	c.44C>T	c.(43-45)TCG>TTG	p.S15L	TM6SF1_uc010bmq.2_Missense_Mutation_p.S15L|TM6SF1_uc002bjq.2_Missense_Mutation_p.S15L|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	15	Helical; (Potential).					integral to membrane				ovary(1)	1						CTGTCCCTCTCGGCCATCCCG	0.567													0	0	0	0.004672	0	3	15										T	83776476	C	T	83776476	3	4	74	1	0	0	0	0	1	0	0	0	15969	893	31	1	46	1	TM6SF1	15	83776476	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6304455	83776476	18754916	230	22782										
ITFG3	83986	broad.mit.edu	37	chr16	304468	304468	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccccttgaaaaatgaagaaaGaaaatcgcaggaaaatctgg	9	7	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:304468G>C	uc002cgf.2	+	3	251	c.56G>C	c.(55-57)AGA>ACA	p.R19T	ITFG3_uc010bqr.2_Intron|ITFG3_uc002cgg.2_Missense_Mutation_p.R19T|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.R19T	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	19	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AATGAAGAAAGAAAATCGCAG	0.502											OREG0003695	type=REGULATORY REGION|Gene=C16orf9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.01441	0	43	138										C	304468	G	C	304468	3	2	74	1	0	0	0	0	1	0	0	0	7871	942	33	1	58	1	ITFG3	16	304468	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		304468	90050285	231	22783										
ITFG3	83986	broad.mit.edu	37	chr16	304632	304632	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cattcgtcatcccgtgtccaGaccggccggcgtcacagcga	11	16	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:304632G>A	uc002cgf.2	+	3	415	c.220G>A	c.(220-222)GAC>AAC	p.D74N	ITFG3_uc010bqr.2_Intron|ITFG3_uc002cgg.2_Missense_Mutation_p.D74N|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.D74N	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	74	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				CCCGTGTCCAGACCGGCCGGC	0.607													0	0	0	0.01441	0	59	287										A	304632	G	A	304632	3	1	74	1	0	0	0	0	1	0	0	0	7871	942	33	1	222	1	ITFG3	16	304632	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	164	304632	90050121	232	22784										
GRIN2A	2903	broad.mit.edu	37	chr16	9862756	9862756	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cggtcggagcacacgcccgtGaaacagaagcgcagcttcca	12	14	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:9862756G>T	uc002czo.3	-	12	3095	c.2547C>A	c.(2545-2547)TTC>TTA	p.F849L	GRIN2A_uc010uym.1_Missense_Mutation_p.F849L|GRIN2A_uc010uyn.1_Missense_Mutation_p.F692L|GRIN2A_uc002czr.3_Missense_Mutation_p.F849L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	849	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ACACGCCCGTGAAACAGAAGC	0.572													1	0	7.41877e-09	0.012319	8.0792e-09	20	57										T	9862756	G	T	9862756	3	4	74	1	0	0	0	0	1	0	0	0	6779	1281	45	3	1855	3	GRIN2A	16	9862756	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	9558124	9862756	80491997	233	22785										
UQCRC2	7385	broad.mit.edu	37	chr16	21985248	21985248	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	taatgccagttactcagattCtggactctttgggatttata	8	7	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:21985248C>G	uc002djx.2	+	11	1134	c.998C>G	c.(997-999)TCT>TGT	p.S333C	UQCRC2_uc002djy.2_Missense_Mutation_p.S333C|UQCRC2_uc010bxa.2_Intron|UQCRC2_uc002djz.1_Missense_Mutation_p.S200C	NM_003366	NP_003357	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	333					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			large_intestine(2)	2				GBM - Glioblastoma multiforme(48;0.0264)		TACTCAGATTCTGGACTCTTT	0.388													0	0	0	0.024245	0	14	57										G	21985248	C	G	21985248	3	3	74	1	0	0	0	0	1	0	0	0	17017	913	32	1	1040	1	UQCRC2	16	21985248	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	12122492	21985248	68369505	234	22786										
GTF3C1	2975	broad.mit.edu	37	chr16	27518439	27518439	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcaaacacgcaggaaatgtaCttggtggttcgctgccgacc	12	11	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:27518439C>G	uc002dov.1	-	9	1321	c.1281G>C	c.(1279-1281)AAG>AAC	p.K427N	GTF3C1_uc002dou.2_Missense_Mutation_p.K427N	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	427						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						AGGAAATGTACTTGGTGGTTC	0.552													0	0	0	0.016522	0	18	80										G	27518439	C	G	27518439	3	3	74	1	0	0	0	0	1	0	0	0	6872	564	20	4	5164	4	GTF3C1	16	27518439	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5533191	27518439	62836314	235	22787										
SNX20	124460	broad.mit.edu	37	chr16	50709713	50709713	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gacttttctctcctcgatgcGagctgaagcgatctcaaaga	9	11	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:50709713G>C	uc002egk.2	-	3	423	c.250C>G	c.(250-252)CGC>GGC	p.R84G	SNX20_uc010vgp.1_Missense_Mutation_p.R84G|SNX20_uc002egi.3_Missense_Mutation_p.R84G	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	84	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						TCCTCGATGCGAGCTGAAGCG	0.418													0	0	0	0.012319	0	17	115										C	50709713	G	C	50709713	3	2	74	1	0	0	0	0	1	0	0	0	14892	1058	37	1	851	1	SNX20	16	50709713	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	23191274	50709713	39645040	236	22788										
CHD9	80205	broad.mit.edu	37	chr16	53288443	53288443	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atgagagagagatgtttgacCgagccagtttgaaactgggc	14	6	0	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:53288443C>T	uc002ehb.2	+	17	4119	c.3955C>T	c.(3955-3957)CGA>TGA	p.R1319*	CHD9_uc002egy.2_Nonsense_Mutation_p.R1319*|CHD9_uc002ehc.2_Nonsense_Mutation_p.R1319*|CHD9_uc002ehf.2_Nonsense_Mutation_p.R433*|CHD9_uc002ehd.2_Nonsense_Mutation_p.R845*	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1319	Helicase C-terminal.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GATGTTTGACCGAGCCAGTTT	0.413													0	0	0	0.012213	0	31	176										T	53288443	C	T	53288443	4	4	74	1	0	0	0	0	0	1	0	0	3332	644	23	2	4021	2	CHD9	16	53288443	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2578730	53288443	37066310	237	22789										
SETD6	79918	broad.mit.edu	37	chr16	58552747	58552747	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cccaagctcaaagcatcgtgGagacagctgcttcaaaacag	9	12	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:58552747G>C	uc002ens.2	+	8	1295	c.1236G>C	c.(1234-1236)TGG>TGC	p.W412C	SETD6_uc002enr.2_Missense_Mutation_p.W388C|SETD6_uc010cdm.2_RNA	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	412					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						AAGCATCGTGGAGACAGCTGC	0.453													0	0	0	0.016522	0	19	64										C	58552747	G	C	58552747	3	2	74	1	0	0	0	0	1	0	0	0	14135	1183	41	1	1266	1	SETD6	16	58552747	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5264304	58552747	31802006	238	22790										
EDC4	23644	broad.mit.edu	37	chr16	67912685	67912685	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtgagtgtgccccctagcctCaaggtttgcttggacctctc	11	13	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:67912685C>G	uc002eur.2	+	11	1396	c.1230C>G	c.(1228-1230)CTC>CTG	p.L410L	EDC4_uc010cer.2_Silent_p.L29L|EDC4_uc010vkg.1_Silent_p.L342L|EDC4_uc010ces.1_Silent_p.L253L|EDC4_uc002eus.2_Silent_p.L140L	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	410					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CCCCTAGCCTCAAGGTTTGCT	0.517													0	0	0	0.01441	0	38	252										G	67912685	C	G	67912685	2	3	74	1	0	0	0	0	0	0	0	1	4908	813	29	1		1	EDC4	16	67912685	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	9359938	67912685	22442068	239	22791										
EDC4	23644	broad.mit.edu	37	chr16	67912931	67912931	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttcagctccatctcggagttCctgctcacccaccctgtgct	7	17	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:67912931C>A	uc002eur.2	+	12	1525	c.1359C>A	c.(1357-1359)TTC>TTA	p.F453L	EDC4_uc010cer.2_Missense_Mutation_p.F72L|EDC4_uc010vkg.1_Missense_Mutation_p.F385L|EDC4_uc010ces.1_Missense_Mutation_p.F296L|EDC4_uc002eus.2_Missense_Mutation_p.F183L	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	453					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TCTCGGAGTTCCTGCTCACCC	0.592													1	0	1.3612e-06	0.024245	1.43966e-06	14	53										A	67912931	C	A	67912931	3	1	74	1	0	0	0	0	1	0	0	0	4908	854	30	3	1405	3	EDC4	16	67912931	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	246	67912931	22441822	240	22792										
HYDIN	54768	broad.mit.edu	37	chr16	71004428	71004428	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttgacctctgctcaccttttCttctatgagatactgctgat	6	11	4	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:71004428C>T	uc002ezr.2	-	36	5739	c.5611G>A	c.(5611-5613)GAA>AAA	p.E1871K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1872										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTCACCTTTTCTTCTATGAGA	0.418													0	0	0	0.007413	0	13	40										T	71004428	C	T	71004428	3	4	74	1	0	0	0	0	1	0	0	0	7467	922	32	1	9955	1	HYDIN	16	71004428	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3091497	71004428	19350325	241	22793										
ANKRD11	29123	broad.mit.edu	37	chr16	89351727	89351727	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctcctcgtccgacgtgtctGacaggatacgatgggacgct	12	13	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr16:89351727G>C	uc002fmx.1	-	9	1684	c.1223C>G	c.(1222-1224)TCA>TGA	p.S408*	ANKRD11_uc002fmy.1_Nonsense_Mutation_p.S408*|ANKRD11_uc002fnc.1_Nonsense_Mutation_p.S408*|ANKRD11_uc002fnb.1_Nonsense_Mutation_p.S365*	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	408						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CGACGTGTCTGACAGGATACG	0.468													0	0	0	0.00308	0	7	62										C	89351727	G	C	89351727	4	2	74	1	0	0	0	0	0	1	0	0	639	1294	45	1	6788	1	ANKRD11	16	89351727	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	18347299	89351727	1003026	242	22794										
MYO1C	4641	broad.mit.edu	37	chr17	1386204	1386204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggtcccgcacggcacctccgCgctcgggggctgggcaggtc	17	16	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:1386204C>T	uc002fsp.2	-	4	717	c.497G>A	c.(496-498)CGC>CAC	p.R166H	MYO1C_uc002fsn.2_Missense_Mutation_p.R147H|MYO1C_uc002fso.2_Missense_Mutation_p.R131H|MYO1C_uc010vqj.1_Missense_Mutation_p.R131H|MYO1C_uc010vqk.1_Missense_Mutation_p.R142H	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	166	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GGCACCTCCGCGCTCGGGGGC	0.617													0	0	0	0.024245	0	14	29										T	1386204	C	T	1386204	3	4	74	1	0	0	0	0	1	0	0	0	10070	768	27	2	2810	2	MYO1C	17	1386204	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08		1386204	79809006	243	22795										
ATP2A3	489	broad.mit.edu	37	chr17	3831578	3831578	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtggtcagcggctgcctactCcaggcctgcgagactgtcct	13	14	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:3831578C>G	uc002fxb.1	-	21	3175	c.3024G>C	c.(3022-3024)TGG>TGC	p.W1008C	ATP2A3_uc010ckn.1_Intron|ATP2A3_uc002fwx.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fwy.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fwz.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fxa.1_Missense_Mutation_p.W1008C|ATP2A3_uc002fxc.1_Intron|ATP2A3_uc002fxd.1_Intron	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	1008	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GCTGCCTACTCCAGGCCTGCG	0.612													0	0	0	0.006122	0	14	57										G	3831578	C	G	3831578	3	3	74	1	0	0	0	0	1	0	0	0	1138	856	30	1	190	1	ATP2A3	17	3831578	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2445374	3831578	77363632	244	22796										
CYB5D2	124936	broad.mit.edu	37	chr17	4060176	4060176	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttagtggaggtgtgagcagaGactggattggcgtccccagg	17	7	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:4060176G>A	uc002fxm.3	+	4	1183	c.595G>A	c.(595-597)GAC>AAC	p.D199N	CYB5D2_uc010cko.2_Missense_Mutation_p.D87N|CYB5D2_uc002fxl.3_Missense_Mutation_p.D87N	NM_144611	NP_653212	Q8WUJ1	NEUFC_HUMAN	cytochrome b5 domain containing 2	199					nervous system development	extracellular region	heme binding			large_intestine(2)|ovary(1)	3						TGTGAGCAGAGACTGGATTGG	0.572											OREG0024097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.028581	0	13	42										A	4060176	G	A	4060176	3	1	74	1	0	0	0	0	1	0	0	0	4125	942	33	1	609	1	CYB5D2	17	4060176	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	228598	4060176	77135034	245	22797										
CAMTA2	23125	broad.mit.edu	37	chr17	4873702	4873702	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggccagccaggacatggtctCactgagccccacagcccctg	11	17	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:4873702C>G	uc002gah.1	-	17	3046	c.2938G>C	c.(2938-2940)GAG>CAG	p.E980Q	SPAG7_uc002gae.2_5'Flank|SPAG7_uc002gaf.2_5'Flank|CAMTA2_uc010cku.1_Missense_Mutation_p.E1003Q|CAMTA2_uc002gag.1_Missense_Mutation_p.E979Q|CAMTA2_uc002gai.1_Missense_Mutation_p.E982Q|CAMTA2_uc010ckv.1_Missense_Mutation_p.E627Q	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	980					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GACATGGTCTCACTGAGCCCC	0.607													0	0	0	0.010504	0	20	132										G	4873702	C	G	4873702	3	3	74	1	0	0	0	0	1	0	0	0	2614	835	29	1	748	1	CAMTA2	17	4873702	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	813526	4873702	76321508	246	22798										
TP53	7157	broad.mit.edu	37	chr17	7577547	7577547	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggatgggcctccggttcatgCcgcccatgcaggaactgtta	13	12	1	0	rs121912656		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:7577547C>A	uc002gim.2	-	7	928	c.734G>T	c.(733-735)GGC>GTC	p.G245V	TP53_uc002gig.1_Missense_Mutation_p.G245V|TP53_uc002gih.2_Missense_Mutation_p.G245V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113V|TP53_uc010cng.1_Missense_Mutation_p.G113V|TP53_uc002gii.1_Missense_Mutation_p.G113V|TP53_uc010cnh.1_Missense_Mutation_p.G245V|TP53_uc010cni.1_Missense_Mutation_p.G245V|TP53_uc002gij.2_Missense_Mutation_p.G245V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152V|TP53_uc002gio.2_Missense_Mutation_p.G113V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245del(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	1.66031e-10	0.021523	1.83534e-10	21	62										A	7577547	C	A	7577547	3	1	74	1	0	0	0	0	1	0	0	0	16378	739	26	4	556	4	TP53	17	7577547	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2703845	7577547	73617663	247	22799										
DNAH2	146754	broad.mit.edu	37	chr17	7643863	7643863	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttccacaggcttgcctcccGcgaggtgcggctgccccgcg	13	18	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:7643863G>A	uc002giu.1	+	9	1516	c.1502G>A	c.(1501-1503)CGC>CAC	p.R501H	DNAH2_uc002git.2_Missense_Mutation_p.R583H|DNAH2_uc010vuk.1_Missense_Mutation_p.R501H	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	501	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTTGCCTCCCGCGAGGTGCGG	0.672													0	0	0	0.007413	0	14	107										A	7643863	G	A	7643863	3	1	74	1	0	0	0	0	1	0	0	0	4602	1087	38	2	1536	2	DNAH2	17	7643863	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	66316	7643863	73551347	248	22800										
DNAH2	146754	broad.mit.edu	37	chr17	7673955	7673955	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gataagggccatcatcggctCaggtcaggggagctggggct	17	9	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:7673955C>G	uc002giu.1	+	25	4193	c.4179C>G	c.(4177-4179)CTC>CTG	p.L1393L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1393	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ATCATCGGCTCAGGTCAGGGG	0.542													0	0	0	0.006122	0	17	104										G	7673955	C	G	7673955	2	3	74	1	0	0	0	0	0	0	0	1	4602	813	29	1		1	DNAH2	17	7673955	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	30092	7673955	73521255	249	22801										
WDR16	146845	broad.mit.edu	37	chr17	9489122	9489122	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctggtctcaaatgccatcctGaccaggagcatatgatttat	8	10	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:9489122G>A	uc002gly.2	+	2	172	c.103G>A	c.(103-105)GAC>AAC	p.D35N	WDR16_uc002glz.2_Intron|WDR16_uc010coc.2_Missense_Mutation_p.D45N	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	35						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						ATGCCATCCTGACCAGGAGCA	0.433													0	0	0	0.013726	0	31	140										A	9489122	G	A	9489122	3	1	74	1	0	0	0	0	1	0	0	0	17273	1290	45	1	109	1	WDR16	17	9489122	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1815167	9489122	71706088	250	22802										
NCOR1	9611	broad.mit.edu	37	chr17	16040727	16040727	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aaaacacaatcaggaacactCtgtaagaaataaaacaatta	4	7	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:16040727C>G	uc002gpo.2	-	14	1648	c.1408_splice	c.e14-1	p.S470_splice	NCOR1_uc002gpn.2_Splice_Site_p.S470_splice|NCOR1_uc002gpp.1_Splice_Site_p.S361_splice|NCOR1_uc002gpr.2_Splice_Site_p.S361_splice|NCOR1_uc002gps.1_Splice_Site_p.S479_splice|NCOR1_uc010coz.1_Splice_Site_p.S286_splice|NCOR1_uc010cpb.1_Splice_Site_p.S479_splice|NCOR1_uc010cpa.1_Splice_Site_p.S470_splice	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1						cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGAACACTCTGTAAGAAAT	0.294													0	0	0	0.009096	0	4	18										G	16040727	C	G	16040727	5	3	74	1	0	0	0	0	0	0	1	0	10235	927	32	1	6047	1	NCOR1	17	16040727	Splice_Site	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6551605	16040727	65154483	251	22803										
ZNF287	57336	broad.mit.edu	37	chr17	16470799	16470799	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caaaatttgttcctttgagtGaatctcaggtctcagccact	7	10	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:16470799G>A	uc002gqi.2	-	2	700	c.247C>T	c.(247-249)CAC>TAC	p.H83Y		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	76	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TCCTTTGAGTGAATCTCAGGT	0.493													0	0	0	0.024245	0	14	115										A	16470799	G	A	16470799	3	1	74	1	0	0	0	0	1	0	0	0	17822	1290	45	1	2058	1	ZNF287	17	16470799	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	430072	16470799	64724411	252	22804										
SUPT6H	6830	broad.mit.edu	37	chr17	27028139	27028139	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gctcccggcaacggcagcagCagccaaagtaagtatctgga	12	12	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:27028139C>T	uc002hby.2	+	36	5077	c.4987C>T	c.(4987-4989)CAG>TAG	p.Q1663*	SUPT6H_uc010crt.2_Nonsense_Mutation_p.Q1663*	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1663					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ACGGCAGCAGCAGCCAAAGTA	0.627													0	0	0	0.004482	0	7	76										T	27028139	C	T	27028139	4	4	74	1	0	0	0	0	0	1	0	0	15397	711	25	2	5125	2	SUPT6H	17	27028139	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	10557340	27028139	54167071	253	22805										
MMP28	79148	broad.mit.edu	37	chr17	34093889	34093889	+	Frame_Shift_Del	DEL	C	C	-													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaccccacactggcttggggCcccggaacctccagcatcga							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:34093889delC	uc002hjy.1	-	10	1452	c.1193delG	c.(1192-1194)GGCfs	p.G398fs	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	398	Hemopexin-like 2.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGGCTTGGGGCCCCGGAACCT	0.682											OREG0024329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						2	4	---	---								-	34093889	C	-	34093889	7	5	74	1	0	1	0	1	0	0	0	0	9665	739	26	0	373	0	MMP28	17	34093889	Frame_Shift_Del	DEL	C	TCGA-FD-A3B6-01A-21D-A20D-08	7065750	34093889	47101321	254	22806										
KRTAP4-8	728224	broad.mit.edu	37	chr17	39253806	39253806	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caagaggaggcgcagcacacGgggcgggggcaggtggagat	21	8	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:39253806G>A	uc010wfo.1	-	1	570	c.531C>T	c.(529-531)CCC>CCT	p.P177P		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	177						keratin filament					0						CGCAGCACACGGGGCGGGGGC	0.542													0	0	0	0.00308	0	5	4										A	39253806	G	A	39253806	2	1	74	1	0	0	0	0	0	0	0	1	8556	1103	39	2		2	KRTAP4-8	17	39253806	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5159917	39253806	41941404	255	22807										
KCNH4	23415	broad.mit.edu	37	chr17	40315336	40315336	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agctgtgctgccagagtcctCaatgccatccactatcctgg	9	14	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:40315336C>A	uc002hzb.2	-	14	2827	c.2494G>T	c.(2494-2496)GAG>TAG	p.E832*		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	832	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCAGAGTCCTCAATGCCATCC	0.632													1	0	3.59834e-05	0.021553	3.77311e-05	6	25										A	40315336	C	A	40315336	4	1	74	1	0	0	0	0	0	1	0	0	8034	835	29	3	571	3	KCNH4	17	40315336	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1061530	40315336	40879874	256	22808										
KCNH4	23415	broad.mit.edu	37	chr17	40315715	40315715	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agagcacctgggggggccgtGaggggaggcactgtggccct	20	10	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:40315715G>A	uc002hzb.2	-	13	2719	c.2386C>T	c.(2386-2388)CAC>TAC	p.H796Y		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	796	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGGGGGCCGTGAGGGGAGGCA	0.672													0	0	0	0.006214	0	6	20										A	40315715	G	A	40315715	3	1	74	1	0	0	0	0	1	0	0	0	8034	1290	45	1	683	1	KCNH4	17	40315715	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	379	40315715	40879495	257	22809										
KCNH4	23415	broad.mit.edu	37	chr17	40323897	40323897	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cagtgggcaaggagcgcaaaGaccgacatgagcagcgtgag	16	9	0	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:40323897G>A	uc002hzb.2	-	7	1437	c.1104C>T	c.(1102-1104)GTC>GTT	p.V368V		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	368	Helical; Name=Segment S5; (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGAGCGCAAAGACCGACATGA	0.507													0	0	0	0.00308	0	6	62										A	40323897	G	A	40323897	2	1	74	1	0	0	0	0	0	0	0	1	8034	929	33	1		1	KCNH4	17	40323897	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	8182	40323897	40871313	258	22810										
ABCC3	8714	broad.mit.edu	37	chr17	48753883	48753883	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atctccactcttgtggtcatCatggccagcacgccgctctt	8	15	5	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:48753883C>G	uc002isl.2	+	23	3392	c.3312C>G	c.(3310-3312)ATC>ATG	p.I1104M	ABCC3_uc002isn.2_5'Flank	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1104	ABC transmembrane type-1 2.|Helical; Name=14; (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TTGTGGTCATCATGGCCAGCA	0.567													0	0	0	0.009535	0	26	122										G	48753883	C	G	48753883	3	3	74	1	0	0	0	0	1	0	0	0	54	816	29	1	3486	1	ABCC3	17	48753883	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	8429986	48753883	32441327	259	22811										
TEX14	56155	broad.mit.edu	37	chr17	56665024	56665024	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaagaaacaggttccacactCatcctgaattgcacgggttt	9	10	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:56665024C>G	uc010dcz.1	-	17	2842	c.2724G>C	c.(2722-2724)ATG>ATC	p.M908I	TEX14_uc002iwr.1_Missense_Mutation_p.M902I|TEX14_uc002iws.1_Missense_Mutation_p.M902I|TEX14_uc010dda.1_Missense_Mutation_p.M682I	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	908						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTCCACACTCATCCTGAATT	0.438											OREG0024616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009535	0	22	39										G	56665024	C	G	56665024	3	3	74	1	0	0	0	0	1	0	0	0	15775	826	29	1	1837	1	TEX14	17	56665024	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7911141	56665024	24530186	260	22812										
PRR11	55771	broad.mit.edu	37	chr17	57275120	57275120	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggaacaggactgactccagtGatgacgcaggccttaaggag	14	9	0	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:57275120G>A	uc002ixf.1	+	9	1063	c.984G>A	c.(982-984)GTG>GTA	p.V328V	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	328										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TGACTCCAGTGATGACGCAGG	0.358													0	0	0	0.016522	0	21	130										A	57275120	G	A	57275120	2	1	74	1	0	0	0	0	0	0	0	1	12583	1277	45	1		1	PRR11	17	57275120	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	610096	57275120	23920090	261	22813										
ACOX1	51	broad.mit.edu	37	chr17	73974647	73974647	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ataatttcatcagggtcagcGatgccaaactccctcatctt	6	12	5	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:73974647G>A	uc002jqf.2	-	2	527	c.237C>T	c.(235-237)ATC>ATT	p.I79I	ACOX1_uc010wsq.1_Silent_p.I41I|ACOX1_uc002jqe.2_Silent_p.I79I|ACOX1_uc010wsr.1_5'UTR|C17orf106_uc010dgs.1_5'Flank|CDK3_uc002jqg.3_5'Flank	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	79					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						CAGGGTCAGCGATGCCAAACT	0.473													0	0	0	0.009535	0	26	132										A	73974647	G	A	73974647	2	1	74	1	0	0	0	0	0	0	0	1	158	1048	37	1		1	ACOX1	17	73974647	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	16699527	73974647	7220563	262	22814										
NOTUM	147111	broad.mit.edu	37	chr17	79911122	79911122	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cggggcagcgacgtccccttCacctggacatccgtccagtg	12	16	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr17:79911122C>T	uc010wvg.1	-	11	1478	c.1206G>A	c.(1204-1206)GTG>GTA	p.V402V		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	402						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ACGTCCCCTTCACCTGGACAT	0.617													0	0	0	0.009096	0	4	17										T	79911122	C	T	79911122	2	4	74	1	0	0	0	0	0	0	0	1	10552	813	29	1		1	NOTUM	17	79911122	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	5936475	79911122	1284088	263	22815										
KIAA1632	57724	broad.mit.edu	37	chr18	43510647	43510647	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acttcatattctaacctcatAtatctccagaacaataattt	1	10	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:43510647A>G	uc002lbm.2	-	12	2507	c.2407T>C	c.(2407-2409)TAT>CAT	p.Y803H	KIAA1632_uc002lbo.1_Missense_Mutation_p.Y803H	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	803					autophagy						0						CTAACCTCATATATCTCCAGA	0.358													0	0	0	0.034045	0	23	29										G	43510647	A	G	43510647	3	3	74	1	0	0	0	0	1	0	0	0	8249	449	16	5	5464	5	KIAA1632	18	43510647	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08		43510647	34566601	264	22816										
MAPK4	5596	broad.mit.edu	37	chr18	48241459	48241459	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgtctttcagggttatctgtCagaagggttggtaacaaagt	12	5	4	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:48241459C>T	uc002lev.2	+	3	1557	c.557C>T	c.(556-558)TCA>TTA	p.S186L	MAPK4_uc010xdm.1_5'UTR|MAPK4_uc010doz.2_Missense_Mutation_p.S186L	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	186	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGTTATCTGTCAGAAGGGTTG	0.512													0	0	0	0.024334	0	21	117										T	48241459	C	T	48241459	3	4	74	1	0	0	0	0	1	0	0	0	9280	838	29	1	563	1	MAPK4	18	48241459	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4730812	48241459	29835789	265	22817										
SERPINB11	89778	broad.mit.edu	37	chr18	61377511	61377511	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aacaacataggagataacatCttcttttcttcgctgagtct	6	9	4	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:61377511C>G	uc002ljk.3	+	2	146	c.84C>G	c.(82-84)ATC>ATG	p.I28M	SERPINB11_uc010xes.1_Translation_Start_Site|SERPINB11_uc010dqd.2_Translation_Start_Site|SERPINB11_uc002ljj.3_Translation_Start_Site|SERPINB11_uc010dqe.2_Translation_Start_Site|SERPINB11_uc010dqf.2_Missense_Mutation_p.I28M	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	28					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GAGATAACATCTTCTTTTCTT	0.448													0	0	0	0.016522	0	21	27										G	61377511	C	G	61377511	3	3	74	1	0	0	0	0	1	0	0	0	14098	903	32	1	86	1	SERPINB11	18	61377511	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	13136052	61377511	16699737	266	22818										
CDH19	28513	broad.mit.edu	37	chr18	64212042	64212043	+	Missense_Mutation	DNP	CC	CC	TT													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atcctcttcaatgctgtaatCcatttctgcattctctccta							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:64212042_64212043CC>TT	uc002lkc.1	-	6	1011_1012	c.873_874GG>AA	c.(871-876)ATGGAT>ATAAAT	p.291_292MD>IN	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.291_292MD>IN|CDH19_uc002lkd.2_Missense_Mutation_p.291_292MD>IN	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	291_292	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				ATGCTGTAATCCATTTCTGCAT	0.351													0	0	0	0.004672	0	33	30										TT	64212043	CC	TT	64212042	3	4	74	1	0	0	0	0	1	0	0	0	3104	855	30	1	1472	1	CDH19	18	64212042	Missense_Mutation	DNP	CC	TCGA-FD-A3B6-01A-21D-A20D-08	2834531	64212042	13865206	267	22819										
CYB5A	1528	broad.mit.edu	37	chr18	71920849	71920849	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gccatgtataggcgatacatCaaggcgacggccactgcaga	12	11	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr18:71920849C>G	uc002lli.2	-	5	486	c.375G>C	c.(373-375)TTG>TTC	p.L125F	CYB5A_uc002llh.2_3'UTR	NM_148923	NP_683725	P00167	CYB5_HUMAN	cytochrome b-5 isoform 1	125	Helical; (Potential).				electron transport chain|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane	aldo-keto reductase (NADP) activity|cytochrome-c oxidase activity|enzyme binding|heme binding				0		Esophageal squamous(42;0.0749)|Prostate(75;0.157)|Melanoma(33;0.211)			Methoxyflurane(DB01028)	GGCGATACATCAAGGCGACGG	0.512													0	0	0	0.004672	0	3	55										G	71920849	C	G	71920849	3	3	74	1	0	0	0	0	1	0	0	0	4122	825	29	1	33	1	CYB5A	18	71920849	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	7708807	71920849	6156399	268	22820										
MIER2	54531	broad.mit.edu	37	chr19	325674	325674	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caagtgcaggttgctgaggtCagcttggaactgaggtccca	14	9	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:325674C>T	uc002lok.1	-	7	625	c.616G>A	c.(616-618)GAC>AAC	p.D206N		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	206	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGCTGAGGTCAGCTTGGAAC	0.607													0	0	0	0.012319	0	15	73										T	325674	C	T	325674	3	4	74	1	0	0	0	0	1	0	0	0	9581	826	29	1	1053	1	MIER2	19	325674	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08		325674	58803309	269	22821										
SAFB2	9667	broad.mit.edu	37	chr19	5613501	5613501	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ttactttgaagttcaacgatGaagtttccaaagtgttctta	7	6	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:5613501G>T	uc002mcd.2	-	5	793	c.581C>A	c.(580-582)TCA>TAA	p.S194*	SAFB2_uc010xio.1_Nonsense_Mutation_p.S194*|SAFB2_uc010xip.1_RNA	NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GTTCAACGATGAAGTTTCCAA	0.423													1	0	7.41877e-09	0.012319	8.0792e-09	17	59										T	5613501	G	T	5613501	4	4	74	1	0	0	0	0	0	1	0	0	13807	1294	45	3	2348	3	SAFB2	19	5613501	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	5287827	5613501	53515482	270	22822										
LRRC8E	80131	broad.mit.edu	37	chr19	7965381	7965381	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctcaggagcctggagcagctCtacctcagctacaacaagct	9	14	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:7965381C>G	uc002mir.2	+	3	2075	c.1974C>G	c.(1972-1974)CTC>CTG	p.L658L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	658	LRR 7.					integral to membrane				lung(1)|pancreas(1)	2						TGGAGCAGCTCTACCTCAGCT	0.632													0	0	0	0.02938	0	7	24										G	7965381	C	G	7965381	2	3	74	1	0	0	0	0	0	0	0	1	9025	900	32	1		1	LRRC8E	19	7965381	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2351880	7965381	51163602	271	22823										
MUC16	94025	broad.mit.edu	37	chr19	9086461	9086461	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agctggactctgtccttgctGaagacttggagatgtctgag	13	8	2	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:9086461G>T	uc002mkp.2	-	1	5558	c.5354C>A	c.(5353-5355)TCA>TAA	p.S1785*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1785	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTCCTTGCTGAAGACTTGGA	0.468													1	0	3.57192e-18	0.006122	4.03353e-18	15	55										T	9086461	G	T	9086461	4	4	74	1	0	0	0	0	0	1	0	0	9973	1294	45	3	38505	3	MUC16	19	9086461	Nonsense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1121080	9086461	50042522	272	22824										
MUC16	94025	broad.mit.edu	37	chr19	9088659	9088659	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atgggcagatggcttgtgtcCaatcttccttcagtaatgta	10	8	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:9088659C>T	uc002mkp.2	-	1	3360	c.3156G>A	c.(3154-3156)TTG>TTA	p.L1052L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1052	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTTGTGTCCAATCTTCCTT	0.478													0	0	0	0.008871	0	19	65										T	9088659	C	T	9088659	2	4	74	1	0	0	0	0	0	0	0	1	9973	593	21	2		2	MUC16	19	9088659	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2198	9088659	50040324	273	22825										
TNPO2	30000	broad.mit.edu	37	chr19	12829859	12829859	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcaccaatggtggctcggatGagcgaggaggcatcgccaat	14	10	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:12829859G>A	uc002muo.2	-	4	494	c.309C>T	c.(307-309)CTC>CTT	p.L103L	TNPO2_uc002mup.2_Silent_p.L195L|TNPO2_uc002muq.2_Silent_p.L103L|TNPO2_uc002mur.2_Silent_p.L103L	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	103					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						TGGCTCGGATGAGCGAGGAGG	0.463													0	0	0	0.021022	0	31	131										A	12829859	G	A	12829859	2	1	74	1	0	0	0	0	0	0	0	1	16333	1277	45	1		1	TNPO2	19	12829859	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3741200	12829859	46299124	274	22826										
RFX1	5989	broad.mit.edu	37	chr19	14079426	14079426	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gcgctgatgtccgacagcccCgtgctcggctgctgccccac	12	18	0	1	rs150138140		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:14079426C>T	uc002mxv.2	-	12	1955	c.1683G>A	c.(1681-1683)ACG>ACA	p.T561T		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	561					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CCGACAGCCCCGTGCTCGGCT	0.662													0	0	0	0.034045	0	21	64										T	14079426	C	T	14079426	2	4	74	1	0	0	0	0	0	0	0	1	13262	639	23	2		2	RFX1	19	14079426	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1249567	14079426	45049557	275	22827										
CYP4F12	66002	broad.mit.edu	37	chr19	15794528	15794528	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gattttttcaaagacaaagcCaagtccaagactttggattt	7	7	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:15794528C>G	uc002nbl.2	+	7	934	c.873C>G	c.(871-873)GCC>GCG	p.A291A		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					AAGACAAAGCCAAGTCCAAGA	0.488													0	0	0	0.021523	0	21	85										G	15794528	C	G	15794528	2	3	74	1	0	0	0	0	0	0	0	1	4187	581	21	4		4	CYP4F12	19	15794528	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1715102	15794528	43334455	276	22828										
RAB3A	5864	broad.mit.edu	37	chr19	18311177	18311177	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggattcctcgttggtgatgtCatacatgaggatgaagccca	12	8	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:18311177C>A	uc002nie.2	-	3	476	c.307G>T	c.(307-309)GAC>TAC	p.D103Y		NM_002866	NP_002857	P20336	RAB3A_HUMAN	RAB3A, member RAS oncogene family	103					glutamate secretion|protein transport|small GTPase mediated signal transduction	clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|plasma membrane|synaptic vesicle	GTP binding|GTPase activity				0						TTGGTGATGTCATACATGAGG	0.443													1	0	3.5997e-14	0.014323	4.01547e-14	18	96										A	18311177	C	A	18311177	3	1	74	1	0	0	0	0	1	0	0	0	12931	826	29	3	367	3	RAB3A	19	18311177	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2516649	18311177	40817806	277	22829										
ZNF100	163227	broad.mit.edu	37	chr19	21909652	21909652	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aaaagctttgccacattcctCacatttgtagggtttctctc	6	11	2	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:21909652C>G	uc002nqi.2	-	5	1661	c.1462G>C	c.(1462-1464)GAG>CAG	p.E488Q	ZNF100_uc002nqh.2_Missense_Mutation_p.E424Q	NM_173531	NP_775802	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	488	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCACATTCCTCACATTTGTAG	0.398													0	0	0	0.028581	0	11	85										G	21909652	C	G	21909652	3	3	74	1	0	0	0	0	1	0	0	0	17710	835	29	1	170	1	ZNF100	19	21909652	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3598475	21909652	37219331	278	22830										
WTIP	126374	broad.mit.edu	37	chr19	34983976	34983976	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gggaaggcgttctacaacgtGggtgagaaagtgtactgcca	15	7	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:34983976G>C	uc002nvm.2	+	3	804	c.804G>C	c.(802-804)GTG>GTC	p.V268V		NM_001080436	NP_001073905			Wilms tumor 1 interacting protein												0	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TCTACAACGTGGGTGAGAAAG	0.627													0	0	0	0.027356	0	23	134										C	34983976	G	C	34983976	2	2	74	1	0	0	0	0	0	0	0	1	17407	1335	47	4		4	WTIP	19	34983976	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	13074324	34983976	24145007	279	22831										
ZNF382	84911	broad.mit.edu	37	chr19	37117266	37117266	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agtcattagaaatataagccCcataaaagagaagtttggtg	9	5	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:37117266C>A	uc002oek.2	+	5	580	c.467C>A	c.(466-468)CCC>CAC	p.P156H	ZNF382_uc010efa.2_Missense_Mutation_p.P107H|ZNF382_uc010efb.2_Missense_Mutation_p.P155H|ZNF382_uc002oel.2_Missense_Mutation_p.P155H	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	156	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AATATAAGCCCCATAAAAGAG	0.343													1	0	3.62473e-10	0.012319	3.99482e-10	15	140										A	37117266	C	A	37117266	3	1	74	1	0	0	0	0	1	0	0	0	17870	623	22	4	477	4	ZNF382	19	37117266	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2133290	37117266	22011717	280	22832										
SIPA1L3	23094	broad.mit.edu	37	chr19	38673330	38673330	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aagcacccaacagggtggaaGagaacggaggagcccccacc	13	13	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:38673330G>C	uc002ohk.2	+	16	4889	c.4380G>C	c.(4378-4380)AAG>AAC	p.K1460N		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1460					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CAGGGTGGAAGAGAACGGAGG	0.642													0	0	0	0.010504	0	17	61										C	38673330	G	C	38673330	3	2	74	1	0	0	0	0	1	0	0	0	14331	933	33	1	4434	1	SIPA1L3	19	38673330	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	1556064	38673330	20455653	281	22833										
PSG1	5669	broad.mit.edu	37	chr19	43382064	43382064	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggatcatgtggaatcacttaCggtgtaaggtgaaggtgaaa	14	4	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:43382064C>T	uc002ovb.2	-	2	568	c.430_splice	c.e2+1	p.L144_splice	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Splice_Site_p.L144_splice|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Splice_Site|PSG1_uc002our.1_Splice_Site_p.L144_splice|PSG1_uc010eio.1_Splice_Site_p.L144_splice|PSG1_uc002oux.1_Intron|PSG1_uc002ouy.1_Splice_Site_p.L144_splice|PSG1_uc002ouz.1_Splice_Site_p.L144_splice|PSG1_uc002ova.1_Splice_Site_p.P144_splice|PSG1_uc002ovc.2_Splice_Site_p.P144_splice|PSG1_uc002ovd.1_Splice_Site_p.L144_splice	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1						female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GAATCACTTACGGTGTAAGGT	0.517													0	0	0	0.01441	0	127	204										T	43382064	C	T	43382064	5	4	74	1	0	0	0	0	0	0	1	0	12653	550	19	2	901	2	PSG1	19	43382064	Splice_Site	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4708734	43382064	15746919	282	22834										
PSG2	5670	broad.mit.edu	37	chr19	43575870	43575870	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	accagagactttgactgtcaAcgatgtggagctttcctcgc	10	11	1	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:43575870A>G	uc002ovr.2	-	4	1039	c.946T>C	c.(946-948)TTG>CTG	p.L316L	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Silent_p.L316L|PSG2_uc010eiq.1_Silent_p.L316L|PSG2_uc002ovs.3_Silent_p.L316L|PSG2_uc002ovt.3_Silent_p.L316L	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	316	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTGACTGTCAACGATGTGGAG	0.458													0	0	0	0.036044	0	37	243										G	43575870	A	G	43575870	2	3	74	1	0	0	0	0	0	0	0	1	12655	40	2	5		5	PSG2	19	43575870	Silent	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	193806	43575870	15553113	283	22835										
XRCC1	7515	broad.mit.edu	37	chr19	44050093	44050093	+	Missense_Mutation	SNP	C	C	T													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gccagggggcagtctgtgttCcttctgctctgccaccctgg							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:44050093C>T	uc002owt.2	-	14	1618	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	XRCC1_uc010xwp.1_Missense_Mutation_p.E469K	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	500					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				AGTCTGTGTTCCTTCTGCTCT	0.627								Other_BER_factors					0	0	0	0.014758	0	4	35										T	44050093	C	T	44050093	3	4	74	1	0	0	0	0	1	0	0	0	17449	864	30	1	419	1	XRCC1	19	44050093	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	474223	44050093	15078890	284	22836	114	2								
XRCC1	7515	broad.mit.edu	37	chr19	44050097	44050097	+	Silent	SNP	C	C	T													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gggggcagtctgtgttccttCtgctctgccaccctgggggt							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:44050097C>T	uc002owt.2	-	14	1614	c.1494G>A	c.(1492-1494)CAG>CAA	p.Q498Q	XRCC1_uc010xwp.1_Silent_p.Q467Q	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	498					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGTGTTCCTTCTGCTCTGCCA	0.632								Other_BER_factors					0	0	0	0.021553	0	5	34										T	44050097	C	T	44050097	2	4	74	1	0	0	0	0	0	0	0	1	17449	912	32	1		1	XRCC1	19	44050097	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	4	44050097	15078886	285	22837	114	2								
XRCC1	7515	broad.mit.edu	37	chr19	44051059	44051059	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgaggaagcttgggggcttCatctccgctgccaccgctgt	13	13	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:44051059C>T	uc002owt.2	-	11	1390	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K	XRCC1_uc010xwp.1_Missense_Mutation_p.E393K	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	424					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TTGGGGGCTTCATCTCCGCTG	0.607								Other_BER_factors					0	0	0	0.021523	0	22	97										T	44051059	C	T	44051059	3	4	74	1	0	0	0	0	1	0	0	0	17449	835	29	1	659	1	XRCC1	19	44051059	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	962	44051059	15077924	286	22838										
MYPOP	339344	broad.mit.edu	37	chr19	46393972	46393972	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgtgcggagggagcggggctGgggggggccggggtgccccc	25	11	0	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:46393972G>A	uc002pdt.2	-	3	1196	c.1109C>T	c.(1108-1110)CCA>CTA	p.P370L		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	370	Pro-rich.					nucleus	DNA binding				0						GAGCGGGGCTGGGGGGGGCCG	0.662													0	0	0	0.004672	0	3	9										A	46393972	G	A	46393972	3	1	74	1	0	0	0	0	1	0	0	0	10099	1348	47	2	94	2	MYPOP	19	46393972	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2342913	46393972	12735011	287	22839										
TRPM4	54795	broad.mit.edu	37	chr19	49674990	49674990	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgagatcgaatcaggcgtttCtttcccaaaggggaccttga	11	10	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:49674990C>G	uc002pmw.2	+	8	1086	c.1014C>G	c.(1012-1014)TTC>TTG	p.F338L	TRPM4_uc010emu.2_Missense_Mutation_p.F338L|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_Missense_Mutation_p.F164L|TRPM4_uc010emv.2_Missense_Mutation_p.F223L|TRPM4_uc010yal.1_Missense_Mutation_p.F55L	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	338	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TCAGGCGTTTCTTTCCCAAAG	0.463													0	0	0	0.007413	0	17	24										G	49674990	C	G	49674990	3	3	74	1	0	0	0	0	1	0	0	0	16585	912	32	1	1044	1	TRPM4	19	49674990	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	3281018	49674990	9453993	288	22840										
ETFB	2109	broad.mit.edu	37	chr19	51856530	51856530	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tctgcacccatggccagggcGgtacgaatcgtctcctgcca	11	15	2	0	rs147509776		TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:51856530G>A	uc002pwh.2	-	3	323	c.231C>T	c.(229-231)ACC>ACT	p.T77T	ETFB_uc002pwg.2_Silent_p.T168T	NM_001985	NP_001976	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	77					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		TGGCCAGGGCGGTACGAATCG	0.512													0	0	0	0.016723	0	10	93										A	51856530	G	A	51856530	2	1	74	1	0	0	0	0	0	0	0	1	5270	1103	39	2		2	ETFB	19	51856530	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	2181540	51856530	7272453	289	22841										
NKG7	4818	broad.mit.edu	37	chr19	51875508	51875508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaccaggaagctcacggacaCcagggcccacagaacagcca	11	15	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:51875508C>T	uc002pwj.2	-	2	382	c.211G>A	c.(211-213)GTG>ATG	p.V71M	NKG7_uc002pwk.2_Intron	NM_005601	NP_005592	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	71	Helical; (Potential).					integral to plasma membrane				central_nervous_system(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CTCACGGACACCAGGGCCCAC	0.617													0	0	0	0.01441	0	47	117										T	51875508	C	T	51875508	3	4	74	1	0	0	0	0	1	0	0	0	10443	507	18	2	298	2	NKG7	19	51875508	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	18978	51875508	7253475	290	22842										
ZNF845	91664	broad.mit.edu	37	chr19	53854452	53854452	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	caacagtgcttcgttggtttCaacatcccaaagaatttctt	6	10	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:53854452C>G	uc010ydv.1	+	4	641	c.524C>G	c.(523-525)TCA>TGA	p.S175*	ZNF845_uc010ydw.1_Nonsense_Mutation_p.S175*	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCGTTGGTTTCAACATCCCAA	0.388													0	0	0	0.0333	0	17	55										G	53854452	C	G	53854452	4	3	74	1	0	0	0	0	0	1	0	0	18188	838	29	1	534	1	ZNF845	19	53854452	Nonsense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1978944	53854452	5274531	291	22843										
ZIK1	284307	broad.mit.edu	37	chr19	58101751	58101751	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gtccctggtctttcctggagGcaagaaacccggcacaatta	10	12	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr19:58101751G>A	uc002qpg.2	+	4	669	c.572G>A	c.(571-573)GGC>GAC	p.G191D	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.G136D|ZIK1_uc002qpi.2_Missense_Mutation_p.G178D|ZIK1_uc002qpj.2_Missense_Mutation_p.G88D	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTTCCTGGAGGCAAGAAACCC	0.498													0	0	0	0.011902	0	39	57										A	58101751	G	A	58101751	3	1	74	1	0	0	0	0	1	0	0	0	17680	1203	42	2	586	2	ZIK1	19	58101751	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	4247299	58101751	1027232	292	22844										
PCSK2	5126	broad.mit.edu	37	chr20	17445975	17445975	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgcttcctgtatccagcctgGgtctgacctggcgggacatg	13	12	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:17445975G>A	uc002wpm.2	+	11	1527	c.1207G>A	c.(1207-1209)GGT>AGT	p.G403S	PCSK2_uc002wpl.2_Missense_Mutation_p.G384S|PCSK2_uc010zrm.1_Missense_Mutation_p.G368S|PCSK2_uc002wpn.2_Missense_Mutation_p.G57S	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	403	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCCAGCCTGGGTCTGACCTG	0.562													0	0	0	0.016522	0	21	42										A	17445975	G	A	17445975	3	1	74	1	0	0	0	0	1	0	0	0	11601	1232	43	2	1249	2	PCSK2	20	17445975	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		17445975	45579545	293	22845										
CST1	1469	broad.mit.edu	37	chr20	23731323	23731323	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cggacgtctgtagtagtcatCtttggtggccttgttatact	11	8	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:23731323C>G	uc002wtp.2	-	1	252	c.181G>C	c.(181-183)GAT>CAT	p.D61H		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	61						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					TAGTAGTCATCTTTGGTGGCC	0.567													0	0	0	0.033182	0	35	65										G	23731323	C	G	23731323	3	3	74	1	0	0	0	0	1	0	0	0	3970	913	32	1	256	1	CST1	20	23731323	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6285348	23731323	39294197	294	22846										
PTPRT	11122	broad.mit.edu	37	chr20	40748574	40748574	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	aggtggagggagggcacttaCcttgagtcgcaatgtagtgc	16	7	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:40748574C>T	uc002xkg.2	-	20	3068	c.2884_splice	c.e20+1	p.G962_splice	PTPRT_uc010ggj.2_Splice_Site_p.G981_splice|PTPRT_uc010ggi.2_Splice_Site_p.G165_splice	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T						homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGGGCACTTACCTTGAGTCGC	0.512													0	0	0	0.01441	0	49	104										T	40748574	C	T	40748574	5	4	74	1	0	0	0	0	0	0	1	0	12812	521	18	2	1488	2	PTPRT	20	40748574	Splice_Site	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	17017251	40748574	22276946	295	22847										
SERINC3	10955	broad.mit.edu	37	chr20	43129871	43129871	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggcaccactggtagttgtatCaccaaggatgacgctgtcac	11	11	2	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:43129871C>T	uc002xme.2	-	9	1260	c.1126G>A	c.(1126-1128)GAT>AAT	p.D376N	SERINC3_uc002xmf.1_Missense_Mutation_p.D376N|SERINC3_uc010ggs.1_Missense_Mutation_p.D369N|SERINC3_uc010zwp.1_Missense_Mutation_p.D321N	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	376	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GTAGTTGTATCACCAAGGATG	0.507													0	0	0	0.017118	0	25	158										T	43129871	C	T	43129871	3	4	74	1	0	0	0	0	1	0	0	0	14081	826	29	1	303	1	SERINC3	20	43129871	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	2381297	43129871	19895649	296	22848										
ACOT8	10005	broad.mit.edu	37	chr20	44477114	44477114	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atactggtcaatgagggtctCacagtcaagcagctcttctg	10	10	5	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:44477114C>G	uc002xqa.1	-	3	544	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	ACOT8_uc010zxe.1_Missense_Mutation_p.E155Q|ACOT8_uc002xqc.1_Missense_Mutation_p.E102Q|ACOT8_uc010zxf.1_Intron	NM_005469	NP_005460	O14734	ACOT8_HUMAN	peroxisomal acyl-CoA thioesterase 1 isoform a	155					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				ATGAGGGTCTCACAGTCAAGC	0.453													0	0	0	0.01441	0	48	312										G	44477114	C	G	44477114	3	3	74	1	0	0	0	0	1	0	0	0	156	835	29	1	512	1	ACOT8	20	44477114	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	1347243	44477114	18548406	297	22849										
RAE1	8480	broad.mit.edu	37	chr20	55948726	55948726	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctttgtctttcagcgccaaaGataacttcacctttaaatgt	5	10	3	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr20:55948726G>C	uc002xyg.2	+	10	1098	c.757G>C	c.(757-759)GAT>CAT	p.D253H	RAE1_uc010gis.1_Missense_Mutation_p.D206H|RAE1_uc010git.1_Missense_Mutation_p.D253H|RAE1_uc002xyh.2_Missense_Mutation_p.D253H|RAE1_uc002xyi.2_Missense_Mutation_p.D253H	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	253					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			CAGCGCCAAAGATAACTTCAC	0.418													0	0	0	0.01441	0	65	151										C	55948726	G	C	55948726	3	2	74	1	0	0	0	0	1	0	0	0	12998	942	33	1	791	1	RAE1	20	55948726	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	11471612	55948726	7076794	298	22850										
DONSON	29980	broad.mit.edu	37	chr21	34951767	34951767	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	gaagatttgagcagcatggtCagtgaatgcagagaatgagg	15	4	1	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:34951767C>T	uc002ysk.2	-	9	1519	c.1452G>A	c.(1450-1452)CTG>CTA	p.L484L	DONSON_uc002ysi.1_Silent_p.L244L|DONSON_uc002ysj.2_Silent_p.L117L|DONSON_uc002ysl.2_Silent_p.L117L|DONSON_uc010gme.2_Silent_p.L457L|DONSON_uc002ysm.2_Silent_p.L484L	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	484					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						GCAGCATGGTCAGTGAATGCA	0.443													0	0	0	0.030593	0	23	134										T	34951767	C	T	34951767	2	4	74	1	0	0	0	0	0	0	0	1	4706	813	29	1		1	DONSON	21	34951767	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08		34951767	13178128	299	22851										
PRDM15	63977	broad.mit.edu	37	chr21	43222983	43222983	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcctcgggcaccggagcaccCgcctcctcttctggcttctg	10	18	3	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:43222983C>G	uc002yzq.1	-	30	4041	c.3930G>C	c.(3928-3930)GCG>GCC	p.A1310A	PRDM15_uc002yzo.2_Silent_p.A981A|PRDM15_uc002yzp.2_Silent_p.A1001A|PRDM15_uc002yzr.1_Silent_p.A1001A	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGGAGCACCCGCCTCCTCTT	0.577													0	0	0	0.01441	0	47	294										G	43222983	C	G	43222983	2	3	74	1	0	0	0	0	0	0	0	1	12456	639	23	4		4	PRDM15	21	43222983	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	8271216	43222983	4906912	300	22852										
UMODL1	89766	broad.mit.edu	37	chr21	43504216	43504216	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ctgaatcagtccgggcagttCacgtcaagacctggggcctg	13	12	3	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:43504216C>T	uc002zaf.1	+	3	342	c.342C>T	c.(340-342)TTC>TTT	p.F114F	UMODL1_uc002zad.1_Silent_p.F42F|UMODL1_uc002zae.1_Silent_p.F42F|UMODL1_uc002zag.1_Silent_p.F114F|UMODL1_uc010gow.1_5'Flank|UMODL1_uc002zai.1_5'Flank|UMODL1_uc010gox.1_5'Flank|UMODL1_uc010goy.1_5'Flank|UMODL1_uc002zaj.1_5'Flank|UMODL1_uc010goz.1_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	114	Extracellular (Potential).|WAP.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CCGGGCAGTTCACGTCAAGAC	0.562													0	0	0	0.01441	0	75	200										T	43504216	C	T	43504216	2	4	74	1	0	0	0	0	0	0	0	1	16977	825	29	1		1	UMODL1	21	43504216	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	281233	43504216	4625679	301	22853										
PKNOX1	5316	broad.mit.edu	37	chr21	44427655	44427655	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	atccaaactgctctgaacccGatgcagaaggagtgagccct	10	12	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr21:44427655G>C	uc002zcq.1	+	3	294	c.106G>C	c.(106-108)GAT>CAT	p.D36H	PKNOX1_uc002zcp.1_Missense_Mutation_p.D36H|PKNOX1_uc011aex.1_5'UTR|PKNOX1_uc002zcr.2_Missense_Mutation_p.D36H	NM_004571	NP_004562	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	36							sequence-specific DNA binding			large_intestine(2)	2						CTCTGAACCCGATGCAGAAGG	0.493													0	0	0	0.025465	0	35	190										C	44427655	G	C	44427655	3	2	74	1	0	0	0	0	1	0	0	0	11982	1058	37	1	112	1	PKNOX1	21	44427655	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	923439	44427655	3702240	302	22854										
ENTHD1	150350	broad.mit.edu	37	chr22	40139982	40139982	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	actccccccagtgactactaGaaatgtgacttatattcttt	5	11	1	3			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:40139982G>C	uc003ayg.2	-	7	1777	c.1526C>G	c.(1525-1527)TCT>TGT	p.S509C		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	509										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GTGACTACTAGAAATGTGACT	0.433													0	0	0	0.004482	0	9	35										C	40139982	G	C	40139982	3	2	74	1	0	0	0	0	1	0	0	0	5137	942	33	1	301	1	ENTHD1	22	40139982	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		40139982	11164584	303	22855			3	104		3	3	221	G		2.459099e-06
ENTHD1	150350	broad.mit.edu	37	chr22	40140187	40140187	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccagaaggaaggtccggccaGaattggtgataagagatgag	15	6	0	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:40140187G>A	uc003ayg.2	-	7	1572	c.1321C>T	c.(1321-1323)CTG>TTG	p.L441L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	441										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GGTCCGGCCAGAATTGGTGAT	0.458													0	0	0	0.013537	0	12	35										A	40140187	G	A	40140187	2	1	74	1	0	0	0	0	0	0	0	1	5137	933	33	1		1	ENTHD1	22	40140187	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	205	40140187	11164379	304	22856			3	104		3	3	221	G		2.459099e-06
ENTHD1	150350	broad.mit.edu	37	chr22	40140202	40140202	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ggccagaattggtgataagaGatgagctgacttctctggag	14	6	1	5			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:40140202G>C	uc003ayg.2	-	7	1557	c.1306C>G	c.(1306-1308)CTC>GTC	p.L436V		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	436										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GGTGATAAGAGATGAGCTGAC	0.438													0	0	0	0.006214	0	9	33										C	40140202	G	C	40140202	3	2	74	1	0	0	0	0	1	0	0	0	5137	942	33	1	521	1	ENTHD1	22	40140202	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	15	40140202	11164364	305	22857			3	104		3	3	221	G		2.459099e-06
GRAMD4	23151	broad.mit.edu	37	chr22	47073091	47073091	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	agggatgaggccttcgagacCattctcagccagtacatcaa	10	11	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:47073091C>T	uc003bhx.2	+	18	1719	c.1680C>T	c.(1678-1680)ACC>ACT	p.T560T	GRAMD4_uc010had.2_Silent_p.T476T|GRAMD4_uc003bhy.2_Silent_p.T83T	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	560					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CCTTCGAGACCATTCTCAGCC	0.552													0	0	0	0.014323	0	17	95										T	47073091	C	T	47073091	2	4	74	1	0	0	0	0	0	0	0	1	6752	581	21	2		2	GRAMD4	22	47073091	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	6932889	47073091	4231475	306	22858										
HDAC10	83933	broad.mit.edu	37	chr22	50684743	50684743	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tcaccactggcagtggcgtgGagacatggaacatggatagg	15	8	1	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chr22:50684743G>C	uc003bkg.2	-	17	2007	c.1634C>G	c.(1633-1635)TCC>TGC	p.S545C	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.S271C|HDAC10_uc003bkf.2_Missense_Mutation_p.S271C|HDAC10_uc010hav.2_Missense_Mutation_p.S525C|HDAC10_uc003bkh.2_Missense_Mutation_p.S338C|HDAC10_uc003bki.2_Missense_Mutation_p.S495C|HDAC10_uc003bkj.2_RNA	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	545					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGTGGCGTGGAGACATGGAA	0.582													0	0	0	0.010504	0	16	130										C	50684743	G	C	50684743	3	2	74	1	0	0	0	0	1	0	0	0	7005	1174	41	1	391	1	HDAC10	22	50684743	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	3611652	50684743	619823	307	22859										
SRPX	8406	broad.mit.edu	37	chrX	38019289	38019289	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cctgcacaggtgggctccgtGccagaccaagccaggttgga	14	13	0	1			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:38019289G>A	uc004ddy.1	-	7	1022	c.936C>T	c.(934-936)GGC>GGT	p.G312G	SRPX_uc004ddz.1_Silent_p.G292G|SRPX_uc011mkh.1_Silent_p.G253G|SRPX_uc011mki.1_Silent_p.G312G	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	312	Sushi 3.				cell adhesion	cell surface|membrane					0						TGGGCTCCGTGCCAGACCAAG	0.567													0	0	0	0.014758	0	4	7										A	38019289	G	A	38019289	2	1	74	1	0	0	0	0	0	0	0	1	15163	1306	46	2		2	SRPX	23	38019289	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08		38019289	117251271	308	22860										
SMC1A	8243	broad.mit.edu	37	chrX	53438989	53438989	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tctgccctgactctgactctCttcttccatccgttcttcaa	4	16	6	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:53438989C>T	uc004dsg.2	-	6	1138	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	SMC1A_uc011moe.1_Missense_Mutation_p.E335K|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	357	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CTCTGACTCTCTTCTTCCATC	0.527													0	0	0	0.009096	0	4	6										T	53438989	C	T	53438989	3	4	74	1	0	0	0	0	1	0	0	0	14781	922	32	1	2712	1	SMC1A	23	53438989	Missense_Mutation	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	15419700	53438989	101831571	309	22861										
ITIH5L	347365	broad.mit.edu	37	chrX	54824559	54824560	+	Frame_Shift_Ins	INS	-	-	G													0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	acctttgtgcttgatgaagcINSggggacagggggtccctggt							TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:54824559_54824560insG	uc004dtj.2	-	1	114_115	c.84_85insC	c.(82-87)CCCGCTfs	p.P28fs		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	28_29	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CTTGATGAAGCGGGGACAGGGG	0.48																		2	4	---	---								G	54824560	-	G	54824559	7	5	74	1	0	1	1	0	0	0	0	0	7908	768	27	0	3908	0	ITIH5L	23	54824559	Frame_Shift_Ins	INS	-	TCGA-FD-A3B6-01A-21D-A20D-08	1385570	54824559	100446001	310	22862										
USP51	158880	broad.mit.edu	37	chrX	55514287	55514287	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	ccaagattgattagccctctCaggcctacagtatagactga	8	11	1	4			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:55514287C>G	uc004dun.1	-	2	1165	c.1086G>C	c.(1084-1086)CTG>CTC	p.L362L	USP51_uc011moo.1_Silent_p.L66L	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	362					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						TTAGCCCTCTCAGGCCTACAG	0.403													0	0	0	0.014323	0	20	32										G	55514287	C	G	55514287	2	3	74	1	0	0	0	0	0	0	0	1	17080	813	29	1		1	USP51	23	55514287	Silent	SNP	C	TCGA-FD-A3B6-01A-21D-A20D-08	689728	55514287	99756273	311	22863										
PHKA1	5255	broad.mit.edu	37	chrX	71840611	71840611	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cttggccttggtcaccaaggAcattaagtcgcaggttgttt	11	9	1	0			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:71840611A>C	uc004eax.3	-	19	2402	c.2101T>G	c.(2101-2103)TCC>GCC	p.S701A	PHKA1_uc004eay.3_Missense_Mutation_p.S701A|PHKA1_uc011mqi.1_Intron	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	701					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					GTCACCAAGGACATTAAGTCG	0.552													0	0	0	0.021553	0	5	38										C	71840611	A	C	71840611	3	2	74	1	0	0	0	0	1	0	0	0	11843	275	10	5	1626	5	PHKA1	23	71840611	Missense_Mutation	SNP	A	TCGA-FD-A3B6-01A-21D-A20D-08	16326324	71840611	83429949	312	22864										
L1CAM	3897	broad.mit.edu	37	chrX	153131202	153131202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	tgacctgggccaggtccaccGgccgccacttgaccagcacg	12	17	0	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:153131202G>A	uc004fjb.2	-	19	2612	c.2504C>T	c.(2503-2505)CCG>CTG	p.P835L	L1CAM_uc004fjc.2_Missense_Mutation_p.P835L|L1CAM_uc010nuo.2_Missense_Mutation_p.P830L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	835	Extracellular (Potential).|Fibronectin type-III 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGGTCCACCGGCCGCCACTT	0.587													0	0	0	0.01441	0	35	98										A	153131202	G	A	153131202	3	1	74	1	0	0	0	0	1	0	0	0	8588	1116	39	2	1309	2	L1CAM	23	153131202	Missense_Mutation	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	81290591	153131202	2139358	313	22865										
DNASE1L1	1774	broad.mit.edu	37	chrX	153631496	153631496	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.450479233226837	141	5.1868929808979e-45	3.48811355223307	4.80297249287884	2.67829976759693	0.49829484490657	0.689830814103477	101	cgctttttggtcagtgaagcGcagtcagcattgaagtcccc	11	11	2	2			TCGA-FD-A3B6-01A-21D-A20D-08	TCGA-FD-A3B6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36524c53-ac54-4a42-a982-bed2e4354268	c92207a3-53ed-4c88-9234-ade71d89f609	g.chrX:153631496G>A	uc004fks.1	-	7	752	c.561C>T	c.(559-561)TGC>TGT	p.C187C	RPL10_uc004fkq.1_Intron|RPL10_uc004fkr.1_Intron|DNASE1L1_uc004fkt.1_Silent_p.C187C|DNASE1L1_uc004fku.1_Silent_p.C187C|DNASE1L1_uc004fkv.1_Silent_p.C187C|DNASE1L1_uc004fkw.1_Silent_p.C187C	NM_006730	NP_006721	P49184	DNSL1_HUMAN	deoxyribonuclease I-like 1 precursor	187					DNA catabolic process	endoplasmic reticulum	DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCAGTGAAGCGCAGTCAGCAT	0.602													0	0	0	0.021553	0	5	84										A	153631496	G	A	153631496	2	1	74	1	0	0	0	0	0	0	0	1	4661	1079	38	2		2	DNASE1L1	23	153631496	Silent	SNP	G	TCGA-FD-A3B6-01A-21D-A20D-08	500294	153631496	1639064	314	22866										
SPEN	23013	broad.mit.edu	37	chr1	16260826	16260826	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aacgtcctgaaagggcctgtGaatgttcttacggggccagt	13	9	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:16260826G>C	uc001axk.1	+	11	8295	c.8091G>C	c.(8089-8091)GTG>GTC	p.V2697V	SPEN_uc010obp.1_Silent_p.V2656V	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2697	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AAGGGCCTGTGAATGTTCTTA	0.597													0	0	0	0.00308	0	7	63										C	16260826	G	C	16260826	2	2	75	1	0	0	0	0	0	0	0	1	15037	1277	45	1		1	SPEN	1	16260826	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08		16260826	232989795	1	22867										
GSTM5	2949	broad.mit.edu	37	chr1	110257779	110257779	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttgtggatttccttgcctatGatgtccttgacatgaagcgt	10	8	0	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:110257779G>C	uc001dyn.2	+	7	555	c.484G>C	c.(484-486)GAT>CAT	p.D162H	GSTM5_uc010ovu.1_Missense_Mutation_p.D121H	NM_000851	NP_000842	P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	162	GST C-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			central_nervous_system(6)	6		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	CCTTGCCTATGATGTCCTTGA	0.468													0	0	0	0.006214	0	8	114										C	110257779	G	C	110257779	3	2	75	1	0	0	0	0	1	0	0	0	6841	1290	45	1	510	1	GSTM5	1	110257779	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	93996953	110257779	138992842	2	22868										
NGF	4803	broad.mit.edu	37	chr1	115828746	115828746	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	acacacaggccgtatctatcCggataaaccgccaggcagcc	9	15	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:115828746C>T	uc001efu.1	-	3	840	c.671G>A	c.(670-672)CGG>CAG	p.R224Q		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	224					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CGTATCTATCCGGATAAACCG	0.572													0	0	0	0.00308	0	7	89										T	115828746	C	T	115828746	3	4	75	1	0	0	0	0	1	0	0	0	10395	652	23	2	58	2	NGF	1	115828746	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	5570967	115828746	133421875	3	22869										
ANKRD34A	284615	broad.mit.edu	37	chr1	145473839	145473839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	catccccaggggtggaggacCctgctcccgcctctcctagc	11	18	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:145473839C>T	uc001enq.1	+	4	1804	c.511C>T	c.(511-513)CCT>TCT	p.P171S	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	171											0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGTGGAGGACCCTGCTCCCGC	0.627													0	0	0	0.013726	0	27	77										T	145473839	C	T	145473839	3	4	75	1	0	0	0	0	1	0	0	0	662	623	22	2	513	2	ANKRD34A	1	145473839	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	29645093	145473839	103776782	4	22870										
PI4KB	5298	broad.mit.edu	37	chr1	151271497	151271497	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cactatcagccgaaatcacaAgaatcttgtatggcttgatc	7	10	3	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:151271497A>C	uc001ext.2	-	9	2217	c.1802T>G	c.(1801-1803)CTT>CGT	p.L601R	PI4KB_uc001exr.2_Missense_Mutation_p.L613R|PI4KB_uc001exs.2_Missense_Mutation_p.L586R|PI4KB_uc001exu.2_Missense_Mutation_p.L586R|PI4KB_uc010pcw.1_Missense_Mutation_p.L269R	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	601	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CGAAATCACAAGAATCTTGTA	0.468													0	0	0	0.01441	0	44	101										C	151271497	A	C	151271497	3	2	75	1	0	0	0	0	1	0	0	0	11874	72	3	5	664	5	PI4KB	1	151271497	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	5797658	151271497	97979124	5	22871										
ZBTB7B	51043	broad.mit.edu	37	chr1	154988705	154988705	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gcctgtgccaggaacgacaaGctgaagatccacatgcggaa	12	11	0	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:154988705G>T	uc001fgk.3	+	4	1322	c.1164G>T	c.(1162-1164)AAG>AAT	p.K388N	ZBTB7B_uc009wpa.2_Missense_Mutation_p.K388N|ZBTB7B_uc001fgj.3_Missense_Mutation_p.K422N|ZBTB7B_uc010peq.1_Missense_Mutation_p.K422N|ZBTB7B_uc001fgl.3_Missense_Mutation_p.K388N	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	388	C2H2-type 2.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGAACGACAAGCTGAAGATCC	0.632													1	0	7.34454e-26	0.01441	8.49987e-26	43	74										T	154988705	G	T	154988705	3	4	75	1	0	0	0	0	1	0	0	0	17551	962	34	4	1170	4	ZBTB7B	1	154988705	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	3717208	154988705	94261916	6	22872										
SPTA1	6708	broad.mit.edu	37	chr1	158639226	158639226	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cttcatcatctgccaactttTtcttcttgttgatccagttc	4	12	5	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:158639226T>A	uc001fst.1	-	14	2004	c.1805A>T	c.(1804-1806)AAA>ATA	p.K602I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	602	Spectrin 7.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGCCAACTTTTTCTTCTTGTT	0.388													0	0	0	0.01441	0	94	189										A	158639226	T	A	158639226	3	1	75	1	0	0	0	0	1	0	0	0	15115	1841	64	5	5610	5	SPTA1	1	158639226	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	3650521	158639226	90611395	7	22873										
RC3H1	149041	broad.mit.edu	37	chr1	173916585	173916585	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	agcaccctgatatatagtttTggaagttcgtgagatggcac	11	7	0	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:173916585T>A	uc001gju.3	-	14	2746	c.2659A>T	c.(2659-2661)AAA>TAA	p.K887*	RC3H1_uc010pms.1_Nonsense_Mutation_p.K887*|RC3H1_uc001gjv.2_Nonsense_Mutation_p.K887*|RC3H1_uc010pmt.1_Nonsense_Mutation_p.K887*	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	887					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TATATAGTTTTGGAAGTTCGT	0.463													0	0	0	0.013537	0	8	80										A	173916585	T	A	173916585	4	1	75	1	0	0	0	0	0	1	0	0	13166	1821	63	5	766	5	RC3H1	1	173916585	Nonsense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	15277359	173916585	75334036	8	22874										
C1orf125	126859	broad.mit.edu	37	chr1	179335702	179335702	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctacatcaacatctgagagcAaaaagttaaaagtgtctgta	7	7	3	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:179335702A>G	uc001gmo.2	+	2	185	c.58A>G	c.(58-60)AAA>GAA	p.K20E	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Intron|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.K20E	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	20											0						ATCTGAGAGCAAAAAGTTAAA	0.418													0	0	0	0.013537	0	9	49										G	179335702	A	G	179335702	3	3	75	1	0	0	0	0	1	0	0	0	1993	131	5	5	60	5	C1orf125	1	179335702	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	5419117	179335702	69914919	9	22875										
CR1	1378	broad.mit.edu	37	chr1	207758216	207758216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tcgctgtgaactttctgttcGtgctggtcagtatccacttc	9	11	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:207758216G>A	uc001hfy.2	+	25	4315	c.4175G>A	c.(4174-4176)CGT>CAT	p.R1392H	CR1_uc009xcl.1_Missense_Mutation_p.R942H|CR1_uc001hfx.2_Missense_Mutation_p.R1842H	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1392	Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CTTTCTGTTCGTGCTGGTCAG	0.488													0	0	0	0.006122	0	16	160										A	207758216	G	A	207758216	3	1	75	1	0	0	0	0	1	0	0	0	3840	1145	40	2	5655	2	CR1	1	207758216	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	28422514	207758216	41492405	10	22876										
OR2T4	127074	broad.mit.edu	37	chr1	248525736	248525736	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tgtggtcatcctcttctatgGggctgccatctacacctaca	8	13	4	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr1:248525736G>T	uc001ieh.1	+	1	854	c.854G>T	c.(853-855)GGG>GTG	p.G285V		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	285	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCTTCTATGGGGCTGCCATC	0.552													1	0	2.94398e-08	0.007413	3.22585e-08	14	130										T	248525736	G	T	248525736	3	4	75	1	0	0	0	0	1	0	0	0	11027	1232	43	4	856	4	OR2T4	1	248525736	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	40767520	248525736	724885	11	22877										
CAD	790	broad.mit.edu	37	chr2	27444089	27444089	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tctctttccatctacagtggTttgaatcctcgggcatccac	7	13	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr2:27444089T>G	uc002rji.2	+	3	388	c.226T>G	c.(226-228)TTT>GTT	p.F76V	CAD_uc010eyw.2_Missense_Mutation_p.F76V	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	76	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TCTACAGTGGTTTGAATCCTC	0.532													0	0	0	0.001855	0	9	56										G	27444089	T	G	27444089	3	3	75	1	0	0	0	0	1	0	0	0	2565	1725	60	5	236	5	CAD	2	27444089	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08		27444089	215755284	12	22878										
KCNG3	170850	broad.mit.edu	37	chr2	42720041	42720041	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	atccaggctgcggttgtcggCggctgcgttgcgccagtcgg	17	12	0	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr2:42720041C>A	uc002rsn.2	-	1	1197	c.601G>T	c.(601-603)GCC>TCC	p.A201S	MTA3_uc002rso.1_5'Flank|KCNG3_uc002rsm.2_Missense_Mutation_p.A201S	NM_133329	NP_579875	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G,	201						endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)	1						CGGTTGTCGGCGGCTGCGTTG	0.627													1	0	3.27435e-08	0.00245	3.55009e-08	11	26										A	42720041	C	A	42720041	3	1	75	1	0	0	0	0	1	0	0	0	8029	768	27	4	717	4	KCNG3	2	42720041	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	15275952	42720041	200479332	13	22879										
ATP6V1B1	525	broad.mit.edu	37	chr2	71190385	71190385	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tctacgagcgggcgggccgcGtggagggtcggggaggatcc	21	10	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr2:71190385G>A	uc002shj.2	+	10	1090	c.1003G>A	c.(1003-1005)GTG>ATG	p.V335M	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.V335M|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.V293M	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	335					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GGCGGGCCGCGTGGAGGGTCG	0.627													0	0	0	0.00308	0	6	87										A	71190385	G	A	71190385	3	1	75	1	0	0	0	0	1	0	0	0	1178	1145	40	2	1041	2	ATP6V1B1	2	71190385	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	28470344	71190385	172008988	14	22880										
REG1A	5967	broad.mit.edu	37	chr2	79349974	79349974	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cttccccatctagaaccgccGctggcactggagcagtgggt	12	14	1	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr2:79349974G>A	uc002snz.2	+	5	432	c.329G>A	c.(328-330)CGC>CAC	p.R110H	REG1A_uc010ysd.1_Missense_Mutation_p.R110H	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	110	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TAGAACCGCCGCTGGCACTGG	0.552													0	0	0	0.00499	0	14	139										A	79349974	G	A	79349974	3	1	75	1	0	0	0	0	1	0	0	0	13210	1087	38	2	343	2	REG1A	2	79349974	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	8159589	79349974	163849399	15	22881										
SLC9A4	389015	broad.mit.edu	37	chr2	103148843	103148843	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cacgttcagcgcatgctctcGgatagggtcacttcagaagc	11	12	4	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr2:103148843G>A	uc002tbz.3	+	12	2550	c.2093G>A	c.(2092-2094)CGG>CAG	p.R698Q		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	698	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GCATGCTCTCGGATAGGGTCA	0.448													0	0	0	0.003163	0	14	79										A	103148843	G	A	103148843	3	1	75	1	0	0	0	0	1	0	0	0	14716	1116	39	2	2139	2	SLC9A4	2	103148843	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	23798869	103148843	140050530	16	22882										
CCDC108	255101	broad.mit.edu	37	chr2	219892615	219892615	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	caggcaccgaagtctacctcGacaggctctacactgatggg	11	13	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr2:219892615G>A	uc002vjl.1	-	13	2052	c.1968C>T	c.(1966-1968)GTC>GTT	p.V656V	CCDC108_uc010fwa.1_Silent_p.V99V|CCDC108_uc010zkp.1_Silent_p.V645V|CCDC108_uc010zkq.1_Silent_p.V591V	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	656						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTCTACCTCGACAGGCTCTA	0.617													0	0	0	0.006214	0	10	38										A	219892615	G	A	219892615	2	1	75	1	0	0	0	0	0	0	0	1	2743	1045	37	1		1	CCDC108	2	219892615	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	116743772	219892615	23306758	17	22883										
CCDC13	152206	broad.mit.edu	37	chr3	42777325	42777325	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tcgctgttcagttgctggtcCaggtggtgctgggacactcg	15	10	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr3:42777325C>T	uc003cly.3	-	10	1329	c.1245G>A	c.(1243-1245)CTG>CTA	p.L415L		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	415	Potential.									ovary(1)	1						GTTGCTGGTCCAGGTGGTGCT	0.632													0	0	0	0.013537	0	12	54										T	42777325	C	T	42777325	2	4	75	1	0	0	0	0	0	0	0	1	2765	581	21	2		2	CCDC13	3	42777325	Silent	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08		42777325	155245105	18	22884										
MYNN	55892	broad.mit.edu	37	chr3	169502469	169502469	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	acacagatattaaaaatttaAagaagcacaaaacaaaagtc	4	6	0	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr3:169502469A>T	uc003fft.2	+	7	1972	c.1543A>T	c.(1543-1545)AAG>TAG	p.K515*	MYNN_uc011bpm.1_Nonsense_Mutation_p.K401*|MYNN_uc003ffu.2_Nonsense_Mutation_p.K515*|MYNN_uc003ffv.2_Nonsense_Mutation_p.K242*|MYNN_uc010hwo.2_Intron|MYNN_uc003ffw.1_RNA	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	515	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TAAAAATTTAAAGAAGCACAA	0.234													0	0	0	0.009096	0	3	20										T	169502469	A	T	169502469	4	4	75	1	0	0	0	0	0	1	0	0	10061	15	1	5	1565	5	MYNN	3	169502469	Nonsense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	126725144	169502469	28519961	19	22885										
PIK3CA	5290	broad.mit.edu	37	chr3	178919316	178919316	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttcctagaaaaatatcctctGagtcagtataaggtgagtaa	8	6	2	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr3:178919316G>C	uc003fjk.2	+	4	958	c.801G>C	c.(799-801)CTG>CTC	p.L267L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	267	PI3K-RBD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATATCCTCTGAGTCAGTATA	0.264		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.004672	0	3	28										C	178919316	G	C	178919316	2	2	75	1	0	0	0	0	0	0	0	1	11913	1277	45	1		1	PIK3CA	3	178919316	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	9416847	178919316	19103114	20	22886										
TIGD2	166815	broad.mit.edu	37	chr4	90034354	90034354	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctatgaagtcatcaacatacGaggagcttgatagagttatg	10	6	2	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr4:90034354G>C	uc003hsk.2	+	1	387	c.229G>C	c.(229-231)GAG>CAG	p.E77Q	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	77	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		ATCAACATACGAGGAGCTTGA	0.363													0	0	0	0.010729	0	10	60										C	90034354	G	C	90034354	3	2	75	1	0	0	0	0	1	0	0	0	15893	1059	37	1	231	1	TIGD2	4	90034354	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08		90034354	101119922	21	22887										
OTUD4	54726	broad.mit.edu	37	chr4	146077123	146077125	+	In_Frame_Del	DEL	CAG	CAG	-													0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aggtttaaatccattcacatCagcagcagcagcagcagtct							TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr4:146077123_146077125delCAG	uc003ika.3	-	8	596_598	c.458_460delCTG	c.(457-462)GCTGAT>GAT	p.A153del	OTUD4_uc003ijz.3_In_Frame_Del_p.A153del	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	218							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CCATTCACATCAGCAGCAGCAGC	0.34																		8	264	---	---								-	146077125	CAG	-	146077123	7	5	75	1	0	1	0	1	0	0	0	0	11314	826	29	0	2745	0	OTUD4	4	146077123	In_Frame_Del	DEL	CAG	TCGA-FD-A3B7-01A-31D-A20D-08	56042769	146077123	45077153	22	22888										
DNAH5	1767	broad.mit.edu	37	chr5	13753654	13753654	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aaagctgtagccaacagtacAtcccctaaaatagaaaacaa	5	10	0	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:13753654A>C	uc003jfd.2	-	63	10602	c.10560T>G	c.(10558-10560)GAT>GAG	p.D3520E	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3520					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCAACAGTACATCCCCTAAAA	0.343									Kartagener_syndrome				0	0	0	0.004672	0	3	33										C	13753654	A	C	13753654	3	2	75	1	0	0	0	0	1	0	0	0	4604	214	8	5	3382	5	DNAH5	5	13753654	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08		13753654	167161606	23	22889										
CDH10	1008	broad.mit.edu	37	chr5	24492938	24492938	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aaatttaccttcattatcctGtactgtgaagtttggattga	7	6	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:24492938G>C	uc003jgr.1	-	10	1944	c.1612C>G	c.(1612-1614)CAG>GAG	p.Q538E	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	538	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCATTATCCTGTACTGTGAAG	0.348										HNSCC(23;0.051)			0	0	0	0.001984	0	5	114										C	24492938	G	C	24492938	3	2	75	1	0	0	0	0	1	0	0	0	3096	1386	48	4	766	4	CDH10	5	24492938	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	10739284	24492938	156422322	24	22890										
CDH6	1004	broad.mit.edu	37	chr5	31323023	31323023	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ataacattgtcagttacaacGacgaaggtggtggagaggag	14	5	1	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:31323023G>C	uc003jhe.1	+	12	2307	c.1981G>C	c.(1981-1983)GAC>CAC	p.D661H		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	661	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAGTTACAACGACGAAGGTGG	0.488													0	0	0	0.010729	0	11	48										C	31323023	G	C	31323023	3	2	75	1	0	0	0	0	1	0	0	0	3114	1058	37	1	2023	1	CDH6	5	31323023	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	6830085	31323023	149592237	25	22891										
NR2F1	7025	broad.mit.edu	37	chr5	92923892	92923892	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ccttcttcccggatctgcagAtcaccgaccaggtgtccctg	9	16	3	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:92923892A>G	uc003kkj.2	+	2	2420	c.733A>G	c.(733-735)ATC>GTC	p.I245V		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	245					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		GGATCTGCAGATCACCGACCA	0.647													0	0	0	0.004656	0	19	85										G	92923892	A	G	92923892	3	3	75	1	0	0	0	0	1	0	0	0	10627	333	12	5	739	5	NR2F1	5	92923892	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	61600869	92923892	87991368	26	22892										
SPRY4	81848	broad.mit.edu	37	chr5	141694361	141694363	+	In_Frame_Del	DEL	TGC	TGC	-													0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gagccgttggtcagaggatgTgctgctgctgctgctcacag							TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:141694361_141694363delTGC	uc003lml.2	-	2	570_572	c.311_313delGCA	c.(310-315)AGCACA>ACA	p.S104del	SPRY4_uc010jgi.1_In_Frame_Del_p.S127del	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	104	Poly-Ser.				multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGAGGATGTGCTGCTGCTGCT	0.66									Testicular_Cancer_Familial_Clustering_of									8	212	---	---								-	141694363	TGC	-	141694361	7	5	75	1	0	1	0	1	0	0	0	0	15107	1696	59	0	590	0	SPRY4	5	141694361	In_Frame_Del	DEL	TGC	TCGA-FD-A3B7-01A-31D-A20D-08	48770469	141694361	39220899	27	22893										
IL17B	27190	broad.mit.edu	37	chr5	148753933	148753933	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ggcttctgggccaggtgattCagaagatgcaggtgcagccc	15	10	2	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:148753933C>G	uc003lqo.2	-	3	592	c.542G>C	c.(541-543)TGA>TCA	p.*181S		NM_014443	NP_055258	Q9UHF5	IL17B_HUMAN	interleukin 17B precursor	181					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAGGTGATTCAGAAGATGCA	0.587													0	0	0	0.000602	0	4	61										G	148753933	C	G	148753933	4	3	75	1	0	0	0	0	0	0	0	0	7635	837	29	1	4	1	IL17B	5	148753933	Nonstop_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	7059572	148753933	32161327	28	22894										
CSNK1A1	1452	broad.mit.edu	37	chr5	148904715	148904715	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	catgactagtacattgtagtCtttttcctgaccataccacc	5	12	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr5:148904715C>T	uc003lqx.1	-	3	730	c.250G>A	c.(250-252)GAC>AAC	p.D84N	CSNK1A1_uc011dcc.1_5'UTR|CSNK1A1_uc003lqv.1_5'UTR|CSNK1A1_uc003lqw.1_Missense_Mutation_p.D84N|CSNK1A1_uc003lqy.1_Missense_Mutation_p.D84N|CSNK1A1_uc010jha.1_Missense_Mutation_p.D84N	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	84	Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		ACATTGTAGTCTTTTTCCTGA	0.358													0	0	0	0.001168	0	5	14										T	148904715	C	T	148904715	3	4	75	1	0	0	0	0	1	0	0	0	3950	913	32	1	883	1	CSNK1A1	5	148904715	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	150782	148904715	32010545	29	22895										
SERPINB9	5272	broad.mit.edu	37	chr6	2896393	2896393	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gaagcgactggaaagcccgaTgaatgtcttcctctgtgttt	11	9	2	1	rs146337993		TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr6:2896393T>C	uc003mug.2	-	3	321	c.200A>G	c.(199-201)CAT>CGT	p.H67R	uc003mue.2_Intron	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	67					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GAAAGCCCGATGAATGTCTTC	0.463													0	0	0	0.00278	0	18	75										C	2896393	T	C	2896393	3	2	75	1	0	0	0	0	1	0	0	0	14108	1464	51	5	950	5	SERPINB9	6	2896393	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08		2896393	168218674	30	22896										
HIST1H1T	3010	broad.mit.edu	37	chr6	26107884	26107884	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gctctcttattggttttagcAgtctttggtgacttggagtc	11	7	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr6:26107884A>G	uc003ngj.2	-	1	481	c.438T>C	c.(436-438)ACT>ACC	p.T146T		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	146					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TGGTTTTAGCAGTCTTTGGTG	0.463													0	0	0	0.001168	0	6	52										G	26107884	A	G	26107884	2	3	75	1	0	0	0	0	0	0	0	1	7127	175	7	5		5	HIST1H1T	6	26107884	Silent	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	23211491	26107884	145007183	31	22897										
KIFC1	3833	broad.mit.edu	37	chr6	33371659	33371659	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gaaccagcagcttcaggaccAgctcagagatgcccagcagc	11	14	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr6:33371659A>G	uc003oef.3	+	6	959	c.509A>G	c.(508-510)CAG>CGG	p.Q170R	KIFC1_uc011drf.1_Missense_Mutation_p.Q162R	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	170	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CTTCAGGACCAGCTCAGAGAT	0.557													0	0	0	0.00308	0	6	96										G	33371659	A	G	33371659	3	3	75	1	0	0	0	0	1	0	0	0	8312	188	7	5	531	5	KIFC1	6	33371659	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	7263775	33371659	137743408	32	22898										
CDKN1A	1026	broad.mit.edu	37	chr6	36652009	36652010	+	Frame_Shift_Ins	INS	-	-	G													0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	atggcgggctgcatccaggaINSggcccgtgagcgatggaact							TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr6:36652009_36652010insG	uc003omm.3	+	2	253_254	c.131_132insG	c.(130-132)GAGfs	p.E44fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E78fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E44fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E44fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	44					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						TGCATCCAGGAGGCCCGTGAGC	0.658									Multiple_Endocrine_Neoplasia_type_1									12	65	---	---								G	36652010	-	G	36652009	7	5	75	1	0	1	1	0	0	0	0	0	3158	304	11	0	133	0	CDKN1A	6	36652009	Frame_Shift_Ins	INS	-	TCGA-FD-A3B7-01A-31D-A20D-08	3280350	36652009	134463058	33	22899										
ACTB	60	broad.mit.edu	37	chr7	5567428	5567429	+	Frame_Shift_Ins	INS	-	-	G													0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gccggactcgtcatactcctINSgcttgctgatccacatctgc							TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr7:5567428_5567429insG	uc003sos.3	-	5	1114_1115	c.1078_1079insC	c.(1078-1080)CAGfs	p.Q360fs	ACTB_uc003sor.3_Frame_Shift_Ins_p.Q238fs|ACTB_uc003sot.3_Frame_Shift_Ins_p.Q360fs|ACTB_uc003soq.3_Frame_Shift_Ins_p.Q238fs|ACTB_uc010ksy.2_Frame_Shift_Ins_p.Q238fs	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	360					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GTCATACTCCTGCTTGCTGATC	0.55																		27	351	---	---								G	5567429	-	G	5567428	7	5	75	1	0	1	1	0	0	0	0	0	193	1580	55	0	52	0	ACTB	7	5567428	Frame_Shift_Ins	INS	-	TCGA-FD-A3B7-01A-31D-A20D-08		5567428	153571235	34	22900										
HECW1	23072	broad.mit.edu	37	chr7	43532701	43532701	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	agcatataatgacaagattgTggcatttcttcgccagccaa	8	9	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr7:43532701T>C	uc003tid.1	+	19	3964	c.3359T>C	c.(3358-3360)GTG>GCG	p.V1120A	HECW1_uc011kbi.1_Missense_Mutation_p.V1086A	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1120					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GACAAGATTGTGGCATTTCTT	0.463													0	0	0	0.004007	0	12	49										C	43532701	T	C	43532701	3	2	75	1	0	0	0	0	1	0	0	0	7042	1696	59	5	3425	5	HECW1	7	43532701	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	37965273	43532701	115605962	35	22901										
TAS2R40	259286	broad.mit.edu	37	chr7	142919393	142919393	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctcttgctacagatttggatGatgctggagaacattttcag	10	7	2	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr7:142919393G>T	uc011ksx.1	+	1	222	c.222G>T	c.(220-222)ATG>ATT	p.M74I		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	74	Helical; Name=2; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					AGATTTGGATGATGCTGGAGA	0.453													1	0	2.7689e-08	0.001984	3.06663e-08	7	87										T	142919393	G	T	142919393	3	4	75	1	0	0	0	0	1	0	0	0	15575	1290	45	3	224	3	TAS2R40	7	142919393	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	99386692	142919393	16219270	36	22902										
C8orf86	389649	broad.mit.edu	37	chr8	38373959	38373959	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gaaatggaagaatgagagatCactgtgggctgctgtgtttt	14	4	1	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr8:38373959C>T	uc003xlx.1	-	2	412	c.387G>A	c.(385-387)GTG>GTA	p.V129V		NM_207412	NP_997295	Q6ZUL3	CH086_HUMAN	hypothetical protein LOC389649	129											0						AATGAGAGATCACTGTGGGCT	0.418													0	0	0	0.01441	0	35	113										T	38373959	C	T	38373959	2	4	75	1	0	0	0	0	0	0	0	1	2442	813	29	1		1	C8orf86	8	38373959	Silent	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08		38373959	107990063	37	22903										
C8orf86	389649	broad.mit.edu	37	chr8	38374031	38374031	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tggcctgtattctcataagcCtagagacagggaacagatta	10	8	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr8:38374031C>G	uc003xlx.1	-	2	341	c.316_splice	c.e2-1	p.A106_splice		NM_207412	NP_997295	Q6ZUL3	CH086_HUMAN	hypothetical protein LOC389649												0						TCTCATAAGCCTAGAGACAGG	0.423													0	0	0	0.013537	0	10	68										G	38374031	C	G	38374031	5	3	75	1	0	0	0	0	0	0	1	0	2442	695	24	4	364	4	C8orf86	8	38374031	Splice_Site	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	72	38374031	107989991	38	22904										
RB1CC1	9821	broad.mit.edu	37	chr8	53573712	53573712	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	acctcaacaacagctaagcaGtacatctgaggaactgtact	7	11	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr8:53573712G>A	uc003xre.3	-	10	2046	c.1488C>T	c.(1486-1488)TAC>TAT	p.Y496Y	RB1CC1_uc003xrf.3_Silent_p.Y496Y	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	496					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CAGCTAAGCAGTACATCTGAG	0.363													0	0	0	0.003163	0	10	47										A	53573712	G	A	53573712	2	1	75	1	0	0	0	0	0	0	0	1	13099	1024	36	2		2	RB1CC1	8	53573712	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	15199681	53573712	92790310	39	22905										
IL33	90865	broad.mit.edu	37	chr9	6251156	6251156	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gcaggtagaaagcacaaaagAcatctggtactcgctgcctg	11	10	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr9:6251156A>T	uc003zjt.2	+	4	291	c.234A>T	c.(232-234)AGA>AGT	p.R78S	IL33_uc011lmg.1_Missense_Mutation_p.R78S|IL33_uc011lmh.1_Intron|IL33_uc003zju.1_Missense_Mutation_p.R78S	NM_033439	NP_254274	O95760	IL33_HUMAN	interleukin 33 precursor	78					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity				0		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		AGCACAAAAGACATCTGGTAC	0.478													0	0	0	0.010504	0	18	55										T	6251156	A	T	6251156	3	4	75	1	0	0	0	0	1	0	0	0	7693	272	10	5	244	5	IL33	9	6251156	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08		6251156	134962275	40	22906										
PCSK5	5125	broad.mit.edu	37	chr9	78772065	78772065	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	acgtgtgtgtggagagcacaGaccgacaaatcaagtaatgc	12	8	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr9:78772065G>A	uc004ajz.2	+	11	1955	c.1417G>A	c.(1417-1419)GAC>AAC	p.D473N	PCSK5_uc004ajy.2_Missense_Mutation_p.D473N|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	473	Homo B/P.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GGAGAGCACAGACCGACAAAT	0.522													0	0	0	0.008291	0	11	84										A	78772065	G	A	78772065	3	1	75	1	0	0	0	0	1	0	0	0	11603	942	33	1	1459	1	PCSK5	9	78772065	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	72520909	78772065	62441366	41	22907										
OR13C8	138802	broad.mit.edu	37	chr9	107331818	107331818	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cgatggcactggaccgctatGtggccatctgctacccactg	11	14	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr9:107331818G>T	uc011lvo.1	+	1	370	c.370G>T	c.(370-372)GTG>TTG	p.V124L		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGACCGCTATGTGGCCATCTG	0.537													1	0	4.14922e-12	0.004007	4.69637e-12	13	47										T	107331818	G	T	107331818	3	4	75	1	0	0	0	0	1	0	0	0	10938	1377	48	4	372	4	OR13C8	9	107331818	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	28559753	107331818	33881613	42	22908										
TTF1	7270	broad.mit.edu	37	chr9	135277170	135277170	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gaggctctcaggcatggccaCtgcctcaaattcctggtgat	11	12	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr9:135277170C>A	uc004cbl.2	-	2	1091	c.1039G>T	c.(1039-1041)GTG>TTG	p.V347L	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Intron	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	347					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GGCATGGCCACTGCCTCAAAT	0.483													1	0	2.56e-06	0.009096	2.69061e-06	4	107										A	135277170	C	A	135277170	3	1	75	1	0	0	0	0	1	0	0	0	16715	565	20	4	1718	4	TTF1	9	135277170	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	27945352	135277170	5936261	43	22909										
E2F8	79733	broad.mit.edu	37	chr11	19258890	19258890	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctgccacttcgtcaaggcagAtgtcattattcacagcaggg	10	11	3	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr11:19258890A>C	uc001mpm.2	-	4	944	c.422T>G	c.(421-423)ATC>AGC	p.I141S	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.I141S|E2F8_uc001mpo.1_Missense_Mutation_p.I141S	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	141	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GTCAAGGCAGATGTCATTATT	0.373													0	0	0	0.004482	0	7	36										C	19258890	A	C	19258890	3	2	75	1	0	0	0	0	1	0	0	0	4873	333	12	5	2221	5	E2F8	11	19258890	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08		19258890	115747626	44	22910										
OR8H3	390152	broad.mit.edu	37	chr11	55890296	55890296	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctctcatcactgggccttatGtgattggctttatggactcc	9	11	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr11:55890296G>C	uc001nii.1	+	1	448	c.448G>C	c.(448-450)GTG>CTG	p.V150L		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TGGGCCTTATGTGATTGGCTT	0.453													0	0	0	0.003163	0	15	73										C	55890296	G	C	55890296	3	2	75	1	0	0	0	0	1	0	0	0	11239	1377	48	4	450	4	OR8H3	11	55890296	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	36631406	55890296	79116220	45	22911										
GLYATL2	219970	broad.mit.edu	37	chr11	58604562	58604562	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tgtttctttggtaattccggTataaagaggatggttttcat	10	4	2	1	rs140678694	by1000genomes	TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr11:58604562T>C	uc001nnd.3	-	5	533	c.402A>G	c.(400-402)ATA>ATG	p.I134M	GLYATL2_uc009ymq.2_Missense_Mutation_p.I134M	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	134						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	GTAATTCCGGTATAAAGAGGA	0.388													0	0	0	0.000602	0	5	68										C	58604562	T	C	58604562	3	2	75	1	0	0	0	0	1	0	0	0	6481	1628	57	5	490	5	GLYATL2	11	58604562	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	2714266	58604562	76401954	46	22912										
SHANK2	22941	broad.mit.edu	37	chr11	70333340	70333340	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cgtcttctcggggctgtcctCcacgttggactgcttcacca	10	15	3	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr11:70333340C>T	uc001oqc.2	-	21	3136	c.3058G>A	c.(3058-3060)GAG>AAG	p.E1020K	SHANK2_uc010rqn.1_Missense_Mutation_p.E432K|SHANK2_uc001opz.2_Missense_Mutation_p.E425K|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	641					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGGCTGTCCTCCACGTTGGAC	0.627													0	0	0	0.004007	0	12	195										T	70333340	C	T	70333340	3	4	75	1	0	0	0	0	1	0	0	0	14265	864	30	1	2499	1	SHANK2	11	70333340	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	11728778	70333340	64673176	47	22913										
IQSEC3	440073	broad.mit.edu	37	chr12	248024	248024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tcgccaaccagaacatatccGtctcctcctccacggctctg	6	18	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr12:248024G>A	uc001qhw.1	+	1	592	c.586G>A	c.(586-588)GTC>ATC	p.V196I	IQSEC3_uc001qhu.1_Missense_Mutation_p.V196I|IQSEC3_uc001qht.1_Missense_Mutation_p.V281I|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	499					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GAACATATCCGTCTCCTCCTC	0.711													0	0	0	0.004672	0	3	31										A	248024	G	A	248024	3	1	75	1	0	0	0	0	1	0	0	0	7819	1145	40	2	1509	2	IQSEC3	12	248024	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08		248024	133603871	48	22914										
BAZ2A	11176	broad.mit.edu	37	chr12	57009072	57009072	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttaagccccatgggactctgGgtaccgttggcccagaactc	11	13	1	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr12:57009072G>C	uc001slq.1	-	3	656	c.462C>G	c.(460-462)ACC>ACG	p.T154T	BAZ2A_uc001slp.1_Silent_p.T152T|BAZ2A_uc010sqr.1_Silent_p.T154T|BAZ2A_uc009zow.1_Silent_p.T152T	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	154					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TGGGACTCTGGGTACCGTTGG	0.517													0	0	0	0.013537	0	11	31										C	57009072	G	C	57009072	2	2	75	1	0	0	0	0	0	0	0	1	1331	1219	43	4		4	BAZ2A	12	57009072	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	56761048	57009072	76842823	49	22915										
DNAH10	196385	broad.mit.edu	37	chr12	124416242	124416242	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gccaagtggccaaagaaataGaaaacaagatgcccaaagtc	9	9	0	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr12:124416242G>A	uc001uft.3	+	74	12647	c.12622G>A	c.(12622-12624)GAA>AAA	p.E4208K	DNAH10_uc001ufu.3_Missense_Mutation_p.E121K	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4208					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAAAGAAATAGAAAACAAGAT	0.517													0	0	0	0.001984	0	7	26										A	124416242	G	A	124416242	3	1	75	1	0	0	0	0	1	0	0	0	4598	943	33	1	12916	1	DNAH10	12	124416242	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	67407170	124416242	9435653	50	22916										
RB1	5925	broad.mit.edu	37	chr13	49039215	49039215	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cggtcttcatgcagagactgAaaacaaatattttgcagtat	8	7	2	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr13:49039215A>T	uc001vcb.2	+	22	2459	c.2293A>T	c.(2293-2295)AAA>TAA	p.K765*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	765	Interaction with LIMD1.|Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCAGAGACTGAAAACAAATAT	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.010729	0	9	20										T	49039215	A	T	49039215	4	4	75	1	0	0	0	0	0	1	0	0	13098	247	9	5	2379	5	RB1	13	49039215	Nonsense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08		49039215	66130663	51	22917										
UTP14C	9724	broad.mit.edu	37	chr13	52605023	52605023	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttacccaccatcggcaatttGaaaggaccatccagacccct	6	15	0	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr13:52605023G>C	uc001vgb.2	+	2	2618	c.2083G>C	c.(2083-2085)GAA>CAA	p.E695Q	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	695					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TCGGCAATTTGAAAGGACCAT	0.488													0	0	0	0.00308	0	6	126										C	52605023	G	C	52605023	3	2	75	1	0	0	0	0	1	0	0	0	17093	1291	45	1	2085	1	UTP14C	13	52605023	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	3565808	52605023	62564855	52	22918										
DACH1	1602	broad.mit.edu	37	chr13	72204709	72204709	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gacacttgaattcatgtcccCgttttcagagtctgctccat	7	12	3	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr13:72204709C>T	uc010thn.1	-	4	1528	c.1105G>A	c.(1105-1107)GGG>AGG	p.G369R	DACH1_uc010tho.1_Missense_Mutation_p.G369R|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	369	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TTCATGTCCCCGTTTTCAGAG	0.343													0	0	0	0.000602	0	4	167										T	72204709	C	T	72204709	3	4	75	1	0	0	0	0	1	0	0	0	4220	652	23	2	1051	2	DACH1	13	72204709	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	19599686	72204709	42965169	53	22919										
MDGA2	161357	broad.mit.edu	37	chr14	47342656	47342656	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctatatgttgtccatacatgTgataaaagaagctgaaacaa	7	6	0	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr14:47342656T>G	uc001wwj.3	-	14	2721	c.2525A>C	c.(2524-2526)CAC>CCC	p.H842P	MDGA2_uc001wwh.3_Missense_Mutation_p.H44P|MDGA2_uc001wwi.3_Missense_Mutation_p.H613P|MDGA2_uc010ani.2_Missense_Mutation_p.H402P	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	842	MAM.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TCCATACATGTGATAAAAGAA	0.363													0	0	0	0.006214	0	8	59										G	47342656	T	G	47342656	3	3	75	1	0	0	0	0	1	0	0	0	9407	1696	59	5	361	5	MDGA2	14	47342656	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08		47342656	60006884	54	22920										
C15orf52	388115	broad.mit.edu	37	chr15	40627566	40627566	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tgtacttccagctcagcctgGtgattgctccaccccagggg	11	14	1	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr15:40627566G>A	uc001zlh.3	-	11	1414	c.1398C>T	c.(1396-1398)CAC>CAT	p.H466H	C15orf52_uc010ucn.1_Silent_p.H256H	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	466										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCTCAGCCTGGTGATTGCTCC	0.657													0	0	0	0.000602	0	5	17										A	40627566	G	A	40627566	2	1	75	1	0	0	0	0	0	0	0	1	1800	1252	44	2		2	C15orf52	15	40627566	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08		40627566	61903826	55	22921										
COPS2	9318	broad.mit.edu	37	chr15	49423006	49423006	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttcagtgatgtcattattctGataggcactaatagaaaaac	7	6	3	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr15:49423006G>A	uc001zxf.2	-	10	1034	c.955C>T	c.(955-957)CAG>TAG	p.Q319*	COPS2_uc001zxh.2_Nonsense_Mutation_p.Q326*|COPS2_uc010ufa.1_Nonsense_Mutation_p.Q255*	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	319	PCI.				cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		TCATTATTCTGATAGGCACTA	0.303													0	0	0	0.000602	0	5	24										A	49423006	G	A	49423006	4	1	75	1	0	0	0	0	0	1	0	0	3733	1299	45	1	392	1	COPS2	15	49423006	Nonsense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	8795440	49423006	53108386	56	22922										
GLDN	342035	broad.mit.edu	37	chr15	51675642	51675642	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttccgttgtaggaccttctgGaccaccaggtaagagcccat	10	12	1	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr15:51675642G>T	uc002aba.2	+	3	594	c.425G>T	c.(424-426)GGA>GTA	p.G142V	GLDN_uc010bez.1_Missense_Mutation_p.D125Y|GLDN_uc002abb.2_Missense_Mutation_p.G18V	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	142	Extracellular (Potential).|Collagen-like 1.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		GGACCTTCTGGACCACCAGGT	0.502											OREG0023124	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.39187e-15	0.008871	2.73737e-15	17	130										T	51675642	G	T	51675642	3	4	75	1	0	0	0	0	1	0	0	0	6434	1174	41	3	435	3	GLDN	15	51675642	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	2252636	51675642	50855750	57	22923										
CALML4	91860	broad.mit.edu	37	chr15	68492003	68492003	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tgctgcttgtcatacagggaGaagcattccttgtactctgc	10	10	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr15:68492003G>T	uc002arb.2	-	3	914	c.180C>A	c.(178-180)TTC>TTA	p.F60L	CALML4_uc002arc.2_Intron|CALML4_uc002ard.2_RNA|CALML4_uc002are.2_Intron|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501	Q96GE6	CALL4_HUMAN	calmodulin-like 4 isoform 1	60	EF-hand 1.			F -> S (in Ref. 1; AAG48255).			calcium ion binding				0						CATACAGGGAGAAGCATTCCT	0.627													1	0	2.7689e-08	0.001984	3.06663e-08	4	95										T	68492003	G	T	68492003	3	4	75	1	0	0	0	0	1	0	0	0	2588	933	33	3	422	3	CALML4	15	68492003	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	16816361	68492003	34039389	58	22924										
HCN4	10021	broad.mit.edu	37	chr15	73616166	73616166	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gcagcagcctggacgcggtgCgcgcagtgggccatctcccg	16	15	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr15:73616166C>A	uc002avp.2	-	8	3262	c.2268G>T	c.(2266-2268)GCG>GCT	p.A756A		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	756	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GGACGCGGTGCGCGCAGTGGG	0.632													1	0	3.86212e-05	0.008291	4.01816e-05	9	57										A	73616166	C	A	73616166	2	1	75	1	0	0	0	0	0	0	0	1	6999	755	27	4		4	HCN4	15	73616166	Silent	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	5124163	73616166	28915226	59	22925										
MKL2	57496	broad.mit.edu	37	chr16	14312706	14312706	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aggaggactatccccacactCagggcgatttctcatttgat	9	11	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr16:14312706C>G	uc010uza.1	+	8	699	c.544C>G	c.(544-546)CAG>GAG	p.Q182E	MKL2_uc002dcg.2_Missense_Mutation_p.Q182E|MKL2_uc002dch.2_Missense_Mutation_p.Q171E|MKL2_uc010uzb.1_Missense_Mutation_p.Q131E	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	171					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						TCCCCACACTCAGGGCGATTT	0.502													0	0	0	0.004482	0	7	50										G	14312706	C	G	14312706	3	3	75	1	0	0	0	0	1	0	0	0	9602	827	29	1	566	1	MKL2	16	14312706	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08		14312706	76042047	60	22926										
NSMCE1	197370	broad.mit.edu	37	chr16	27268804	27268804	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	caagcgcttcacgtcccattCctctagcacgccatgggtca	8	16	3	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr16:27268804C>T	uc002doi.1	-	2	186	c.88G>A	c.(88-90)GAA>AAA	p.E30K	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	30					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						ACGTCCCATTCCTCTAGCACG	0.582													0	0	0	0.012213	0	29	63										T	27268804	C	T	27268804	3	4	75	1	0	0	0	0	1	0	0	0	10675	864	30	1	740	1	NSMCE1	16	27268804	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	12956098	27268804	63085949	61	22927										
CBFA2T3	863	broad.mit.edu	37	chr16	88952449	88952449	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	atgggggaggaggcgctggcGtccagcaggagctgctcatg	19	9	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr16:88952449G>A	uc002fmm.1	-	6	999	c.813C>T	c.(811-813)GAC>GAT	p.D271D	CBFA2T3_uc002fml.1_Silent_p.D185D|CBFA2T3_uc010cif.1_Silent_p.D210D|CBFA2T3_uc002fmn.1_Silent_p.D246D	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	271	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		AGGCGCTGGCGTCCAGCAGGA	0.657			T	RUNX1	AML								0	0	0	0.004672	0	2	3										A	88952449	G	A	88952449	2	1	75	1	0	0	0	0	0	0	0	1	2698	1136	40	2		2	CBFA2T3	16	88952449	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	61683645	88952449	1402304	62	22928										
KIF1C	10749	broad.mit.edu	37	chr17	4905382	4905382	+	Frame_Shift_Del	DEL	G	G	-													0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ggacctcttctctcgcgttaGtgagaaccagagtgctcagc							TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:4905382delG	uc002gan.1	+	6	718	c.392delG	c.(391-393)AGTfs	p.S131fs		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	131	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						TCTCGCGTTAGTGAGAACCAG	0.448																		33	115	---	---								-	4905382	G	-	4905382	7	5	75	1	0	1	0	1	0	0	0	0	8285	1029	36	0	406	0	KIF1C	17	4905382	Frame_Shift_Del	DEL	G	TCGA-FD-A3B7-01A-31D-A20D-08		4905382	76289828	63	22929										
ASGR1	432	broad.mit.edu	37	chr17	7077348	7077348	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ttttggtcgtggaggcccatCcaggtgttcacagggcctat	13	10	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:7077348C>T	uc002ges.3	-	8	1043	c.633G>A	c.(631-633)TGG>TGA	p.W211*	ASGR1_uc010clx.1_Nonsense_Mutation_p.W110*	NM_001671	NP_001662	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	211	Extracellular (Probable).|C-type lectin.				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)	2						GGAGGCCCATCCAGGTGTTCA	0.647													0	0	0	0.00245	0	12	67										T	7077348	C	T	7077348	4	4	75	1	0	0	0	0	0	1	0	0	1039	856	30	1	250	1	ASGR1	17	7077348	Nonsense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	2171966	7077348	74117862	64	22930										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.010818	0	22	64										T	7577538	C	T	7577538	3	4	75	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	500190	7577538	73617672	65	22931										
ALOXE3	59344	broad.mit.edu	37	chr17	8012598	8012598	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cggaaggcagaaattggtgtAggtgaagtgggccaggcccg	18	7	0	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:8012598A>C	uc010cnr.2	-	12	1826	c.1456T>G	c.(1456-1458)TAC>GAC	p.Y486D	ALOXE3_uc002gka.2_Missense_Mutation_p.Y642D|ALOXE3_uc010vuo.1_Missense_Mutation_p.Y618D	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	486	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						AAATTGGTGTAGGTGAAGTGG	0.657													0	0	0	0.004672	0	3	42										C	8012598	A	C	8012598	3	2	75	1	0	0	0	0	1	0	0	0	542	420	15	5	699	5	ALOXE3	17	8012598	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	435060	8012598	73182612	66	22932										
SMCR7	125170	broad.mit.edu	37	chr17	18167412	18167412	+	Frame_Shift_Del	DEL	C	C	-													0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aggacgcagcttgagttctgCccccgtgggagcagcccctg							TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:18167412delC	uc002gst.2	+	4	910	c.699delC	c.(697-699)TGCfs	p.C233fs	SMCR7_uc002gsu.2_3'UTR|SMCR7_uc010vxq.1_Frame_Shift_Del_p.C244fs	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	233						integral to membrane	protein binding				0	all_neural(463;0.228)					TTGAGTTCTGCCCCCGTGGGA	0.706																		2	4	---	---								-	18167412	C	-	18167412	7	5	75	1	0	1	0	1	0	0	0	0	14790	747	26	0	746	0	SMCR7	17	18167412	Frame_Shift_Del	DEL	C	TCGA-FD-A3B7-01A-31D-A20D-08	10154814	18167412	63027798	67	22933										
AMAC1	146861	broad.mit.edu	37	chr17	33521026	33521026	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	acagaagaaggcccggcttcGgatgtcaggagttcccagaa	13	10	1	3	rs139972846		TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:33521026G>A	uc002hjd.2	-	1	387	c.301C>T	c.(301-303)CGA>TGA	p.R101*		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	101	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GCCCGGCTTCGGATGTCAGGA	0.607													0	0	0	0.011902	0	43	133										A	33521026	G	A	33521026	4	1	75	1	0	0	0	0	0	1	0	0	559	1124	39	2	719	2	AMAC1	17	33521026	Nonsense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	15353614	33521026	47674184	68	22934										
GGNBP2	79893	broad.mit.edu	37	chr17	34942489	34942489	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gatttctgcaggtgatgactCttgtgttcatcactgtgaag	11	7	4	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:34942489C>G	uc002hnb.2	+	12	1751	c.1502C>G	c.(1501-1503)TCT>TGT	p.S501C	GGNBP2_uc002hna.2_3'UTR|GGNBP2_uc002hnc.1_Missense_Mutation_p.S330C	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	501					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GGTGATGACTCTTGTGTTCAT	0.368													0	0	0	0.008871	0	17	75										G	34942489	C	G	34942489	3	3	75	1	0	0	0	0	1	0	0	0	6359	913	32	1	1544	1	GGNBP2	17	34942489	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	1421463	34942489	46252721	69	22935										
GJC1	10052	broad.mit.edu	37	chr17	42882050	42882050	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tgctactggcagtgcttttgTtggacccagctttggacccc	11	12	0	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:42882050T>G	uc002ihj.2	-	2	1647	c.1136A>C	c.(1135-1137)AAC>ACC	p.N379T	GJC1_uc002ihk.2_Missense_Mutation_p.N379T|GJC1_uc002ihl.2_Missense_Mutation_p.N379T|GJC1_uc010czx.2_Missense_Mutation_p.N379T|GJC1_uc010czy.1_Missense_Mutation_p.N240T	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	379	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				AGTGCTTTTGTTGGACCCAGC	0.517													0	0	0	0.007413	0	15	199										G	42882050	T	G	42882050	3	3	75	1	0	0	0	0	1	0	0	0	6414	1725	60	5	58	5	GJC1	17	42882050	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	7939561	42882050	38313160	70	22936										
TOM1L1	10040	broad.mit.edu	37	chr17	52981124	52981124	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tggggccagttcatgcacatCtgtgacataattaacactac	8	10	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:52981124C>A	uc002iud.2	+	2	289	c.114C>A	c.(112-114)ATC>ATA	p.I38I	TOM1L1_uc002iub.2_Silent_p.I3I|TOM1L1_uc002iuc.2_Silent_p.I38I|TOM1L1_uc010dca.1_Silent_p.I38I|TOM1L1_uc010wnb.1_Silent_p.I38I|TOM1L1_uc010wnc.1_Intron|TOM1L1_uc010dbz.2_Intron|TOM1L1_uc010wnd.1_Translation_Start_Site	NM_005486	NP_005477	O75674	TM1L1_HUMAN	target of myb1-like 1	38	VHS.				intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1						TCATGCACATCTGTGACATAA	0.428													1	0	3.09899e-07	0.004482	3.29067e-07	6	78										A	52981124	C	A	52981124	2	1	75	1	0	0	0	0	0	0	0	1	16349	903	32	3		3	TOM1L1	17	52981124	Silent	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	10099074	52981124	28214086	71	22937										
BCAS3	54828	broad.mit.edu	37	chr17	58952079	58952079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctttgatagctgtactttcaCgaagaaattctttgttacaa	6	7	2	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:58952079C>T	uc002iyv.3	+	9	750	c.641C>T	c.(640-642)ACG>ATG	p.T214M	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Missense_Mutation_p.T214M|BCAS3_uc002iyw.3_Missense_Mutation_p.T210M	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	214						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TGTACTTTCACGAAGAAATTC	0.328													0	0	0	0.000602	0	4	36										T	58952079	C	T	58952079	3	4	75	1	0	0	0	0	1	0	0	0	1352	536	19	2	671	2	BCAS3	17	58952079	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	5970955	58952079	22243131	72	22938										
BPTF	2186	broad.mit.edu	37	chr17	65871019	65871019	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cagaaaaagacaagaatgagActgagaatgactctaaagat	9	5	1	7			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:65871019A>G	uc002jgf.2	+	4	1808	c.1747A>G	c.(1747-1749)ACT>GCT	p.T583A	BPTF_uc002jge.2_Missense_Mutation_p.T583A|BPTF_uc010wqm.1_Missense_Mutation_p.T583A	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	696	Interaction with KEAP1.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAAGAATGAGACTGAGAATGA	0.363													0	0	0	0.001984	0	6	45										G	65871019	A	G	65871019	3	3	75	1	0	0	0	0	1	0	0	0	1495	275	10	5	1761	5	BPTF	17	65871019	Missense_Mutation	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	6918940	65871019	15324191	73	22939										
C17orf28	283987	broad.mit.edu	37	chr17	72954437	72954437	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ctcaccacaatgagcaggtcGgcgtgggtccctgtgaagac	13	12	1	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr17:72954437G>A	uc002jmj.3	-	11	1526	c.1377C>T	c.(1375-1377)GCC>GCT	p.A459A	C17orf28_uc010wrs.1_Silent_p.A258A	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	459						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					TGAGCAGGTCGGCGTGGGTCC	0.662											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	10	22										A	72954437	G	A	72954437	2	1	75	1	0	0	0	0	0	0	0	1	1853	1103	39	2		2	C17orf28	17	72954437	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	7083418	72954437	8240773	74	22940										
SMAD4	4089	broad.mit.edu	37	chr18	48575203	48575203	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tctgtgtgaatccatatcacTacgaacgagttgtatcacct	7	10	3	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr18:48575203T>A	uc010xdp.1	+	3	935	c.397T>A	c.(397-399)TAC>AAC	p.Y133N	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	133	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(4)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TCCATATCACTACGAACGAGT	0.348									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.004007	0	13	35										A	48575203	T	A	48575203	3	1	75	1	0	0	0	0	1	0	0	0	14760	1522	53	5	403	5	SMAD4	18	48575203	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08		48575203	29502045	75	22941										
DPP9	91039	broad.mit.edu	37	chr19	4704288	4704288	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ccctcagcagctcctcctccCgagagtagaccccatggtgg	10	17	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr19:4704288C>T	uc002mba.2	-	6	713	c.455G>A	c.(454-456)CGG>CAG	p.R152Q	DPP9_uc002mbb.2_Missense_Mutation_p.R152Q|DPP9_uc002mbc.2_Missense_Mutation_p.R152Q	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	123					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CTCCTCCTCCCGAGAGTAGAC	0.642													0	0	0	0.008871	0	14	78										T	4704288	C	T	4704288	3	4	75	1	0	0	0	0	1	0	0	0	4733	652	23	2	2291	2	DPP9	19	4704288	Missense_Mutation	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08		4704288	54424695	76	22942										
MUC16	94025	broad.mit.edu	37	chr19	8999557	8999557	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	tttggtggctgccccatcctTcttgggcctggggagggcaa	15	11	1	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr19:8999557T>G	uc002mkp.2	-	56	40822	c.40618A>C	c.(40618-40620)AAG>CAG	p.K13540Q	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.K357Q|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13542	SEA 10.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCCCATCCTTCTTGGGCCTG	0.597													0	0	0	0.001984	0	7	41										G	8999557	T	G	8999557	3	3	75	1	0	0	0	0	1	0	0	0	9973	1792	62	5	3021	5	MUC16	19	8999557	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	4295269	8999557	50129426	77	22943										
DHX34	9704	broad.mit.edu	37	chr19	47884572	47884572	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gcccccaggccccacaggatGggcccccaggtaagcacagg	13	17	0	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr19:47884572G>A	uc010xyn.1	+	16	3630	c.3289G>A	c.(3289-3291)GGG>AGG	p.G1097R	DHX34_uc010xyo.1_Missense_Mutation_p.G226R	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1097						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCCACAGGATGGGCCCCCAGG	0.672													0	0	0	0.010729	0	10	36										A	47884572	G	A	47884572	3	1	75	1	0	0	0	0	1	0	0	0	4507	1348	47	2	3347	2	DHX34	19	47884572	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	38885015	47884572	11244411	78	22944										
SYT5	6861	broad.mit.edu	37	chr19	55690386	55690386	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gtgtcgggcgatggaggcccCggggttgggggctccgggaa	22	9	0	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr19:55690386C>A	uc002qjm.1	-	1	1084	c.24G>T	c.(22-24)CCG>CCT	p.P8P	SYT5_uc002qjp.2_Missense_Mutation_p.R63L|SYT5_uc002qjn.1_Silent_p.P8P|SYT5_uc002qjo.1_Silent_p.P8P	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	8	Vesicular (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		ATGGAGGCCCCGGGGTTGGGG	0.667													1	0	3.09899e-07	0.004482	3.29067e-07	5	14										A	55690386	C	A	55690386	2	1	75	1	0	0	0	0	0	0	0	1	15474	639	23	4		4	SYT5	19	55690386	Silent	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	7805814	55690386	3438597	79	22945										
NLRP4	147945	broad.mit.edu	37	chr19	56370501	56370501	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	agaagctaactttcatattaTtgacaacgtggacttggtgg	10	6	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr19:56370501T>C	uc002qmd.3	+	3	2164	c.1742T>C	c.(1741-1743)ATT>ACT	p.I581T	NLRP4_uc002qmf.2_Missense_Mutation_p.I506T|NLRP4_uc010etf.2_Missense_Mutation_p.I412T	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	581							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTTCATATTATTGACAACGTG	0.418													0	0	0	0.000602	0	5	37										C	56370501	T	C	56370501	3	2	75	1	0	0	0	0	1	0	0	0	10479	1493	52	5	1748	5	NLRP4	19	56370501	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08	680115	56370501	2758482	80	22946										
RNF160	26046	broad.mit.edu	37	chr21	30316094	30316094	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gatattctggtaagtttgttTtttggtcagcaactaatctt	8	5	3	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr21:30316094T>C	uc002ymr.2	-	23	4266	c.4253A>G	c.(4252-4254)AAA>AGA	p.K1418R		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1372							ligase activity|zinc ion binding				0						TAAGTTTGTTTTTTGGTCAGC	0.388													0	0	0	0.005443	0	21	127										C	30316094	T	C	30316094	3	2	75	1	0	0	0	0	1	0	0	0	13455	1841	64	5	1217	5	RNF160	21	30316094	Missense_Mutation	SNP	T	TCGA-FD-A3B7-01A-31D-A20D-08		30316094	17813801	81	22947										
CHAF1B	8208	broad.mit.edu	37	chr21	37781087	37781087	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gtggaatctggtgaaaatgtAatgaataccacttatgtttt	9	4	1	2			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr21:37781087A>C	uc002yvj.2	+	9	924	c.786A>C	c.(784-786)GTA>GTC	p.V262V		NM_005441	NP_005432	Q13112	CAF1B_HUMAN	chromatin assembly factor 1 subunit B	262	WD 5.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2						GTGAAAATGTAATGAATACCA	0.353													0	0	0	0.004482	0	6	64										C	37781087	A	C	37781087	2	2	75	1	0	0	0	0	0	0	0	1	3312	349	13	5		5	CHAF1B	21	37781087	Silent	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08	7464993	37781087	10348808	82	22948										
C21orf56	84221	broad.mit.edu	37	chr21	47588241	47588241	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	ccattgaggtagtagctcctCctggtcctgtccccggtggg	13	13	0	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr21:47588241C>T	uc011afu.1	-	3	1587	c.525G>A	c.(523-525)AGG>AGA	p.R175R	C21orf56_uc002zii.2_Silent_p.R21R	NM_001142854	NP_001136326	Q9H0A9	CU056_HUMAN	hypothetical protein LOC84221 isoform 1	175							protein binding			skin(1)	1	Breast(49;0.214)			Colorectal(79;0.241)		AGTAGCTCCTCCTGGTCCTGT	0.662													0	0	0	0.001168	0	5	48										T	47588241	C	T	47588241	2	4	75	1	0	0	0	0	0	0	0	1	2127	854	30	1		1	C21orf56	21	47588241	Silent	SNP	C	TCGA-FD-A3B7-01A-31D-A20D-08	9807154	47588241	541654	83	22949										
SEZ6L	23544	broad.mit.edu	37	chr22	26743810	26743810	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	gtgaccccggctatgacatcGtggggagtgacaccctcacc	12	14	1	3			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr22:26743810G>A	uc003acb.2	+	11	2494	c.2338G>A	c.(2338-2340)GTG>ATG	p.V780M	SEZ6L_uc003acc.2_Missense_Mutation_p.V780M|SEZ6L_uc011akc.1_Missense_Mutation_p.V780M|SEZ6L_uc003acd.2_Missense_Mutation_p.V780M|SEZ6L_uc011akd.1_Missense_Mutation_p.V780M|SEZ6L_uc003ace.2_Missense_Mutation_p.V780M|SEZ6L_uc003acf.1_Missense_Mutation_p.V553M|SEZ6L_uc010gvc.1_Missense_Mutation_p.V553M|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	780	Sushi 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTATGACATCGTGGGGAGTGA	0.552													0	0	0	0.01441	0	43	74										A	26743810	G	A	26743810	3	1	75	1	0	0	0	0	1	0	0	0	14143	1145	40	2	2380	2	SEZ6L	22	26743810	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08		26743810	24560756	84	22950										
CELSR1	9620	broad.mit.edu	37	chr22	46931440	46931440	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cccctgaagaattgatgagcGggggccggcccccatcctgg	14	14	0	4			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr22:46931440G>C	uc003bhw.1	-	1	1628	c.1628C>G	c.(1627-1629)CCG>CGG	p.P543R		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	543	Extracellular (Potential).|Cadherin 3.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ATTGATGAGCGGGGGCCGGCC	0.582													0	0	0	0.00245	0	13	82										C	46931440	G	C	46931440	3	2	75	1	0	0	0	0	1	0	0	0	3221	1116	39	4	7556	4	CELSR1	22	46931440	Missense_Mutation	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	20187630	46931440	4373126	85	22951										
HDAC10	83933	broad.mit.edu	37	chr22	50688081	50688081	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	cacctggggtcatcctcaaaGagatactggatcccctggcc	10	14	2	1			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chr22:50688081G>C	uc003bkg.2	-	6	919	c.546C>G	c.(544-546)CTC>CTG	p.L182L	HDAC10_uc003bke.2_5'UTR|HDAC10_uc003bkf.2_5'UTR|HDAC10_uc010hav.2_Silent_p.L182L|HDAC10_uc003bkh.2_Missense_Mutation_p.S11C|HDAC10_uc003bki.2_Silent_p.L182L|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_5'Flank	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	182	Histone deacetylase.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CATCCTCAAAGAGATACTGGA	0.622													0	0	0	0.001984	0	5	59										C	50688081	G	C	50688081	2	2	75	1	0	0	0	0	0	0	0	1	7005	929	33	1		1	HDAC10	22	50688081	Silent	SNP	G	TCGA-FD-A3B7-01A-31D-A20D-08	3756641	50688081	616485	86	22952										
CDR1	1038	broad.mit.edu	37	chrX	139866364	139866364	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.149425287356322	13	0.00802369642841907	2.09537847090148	3.78242677824268	1.22276727744914	0.472547597169157	0.68256875146656	7	aaatccgtgtcttccagcaaAtccacgtcttccaacaaagc	5	14	2	0			TCGA-FD-A3B7-01A-31D-A20D-08	TCGA-FD-A3B7-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc76c5bd-315d-4981-ae53-705f40d2c078	1e82025a-5704-46e6-ac57-8f4318969cc5	g.chrX:139866364A>G	uc004fbg.1	-	1	360	c.168T>C	c.(166-168)GAT>GAC	p.D56D	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	56	23 X 6 AA approximate repeats.|9.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CTTCCAGCAAATCCACGTCTT	0.438													0	0	0	0.004672	0	3	46										G	139866364	A	G	139866364	2	3	75	1	0	0	0	0	0	0	0	1	3171	98	4	5		5	CDR1	23	139866364	Silent	SNP	A	TCGA-FD-A3B7-01A-31D-A20D-08		139866364	15404196	87	22953										
RERE	473	broad.mit.edu	37	chr1	8419925	8419925	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tcgggctttctgctcagcctCgcgcttggccttctcaatgg	11	14	3	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:8419925C>T	uc001ape.2	-	20	4327	c.3517G>A	c.(3517-3519)GAG>AAG	p.E1173K	RERE_uc001apf.2_Missense_Mutation_p.E1173K|RERE_uc001apd.2_Missense_Mutation_p.E619K	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1173	Potential.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TGCTCAGCCTCGCGCTTGGCC	0.498													0	0	0	0.02938	0	4	58										T	8419925	C	T	8419925	3	4	76	1	0	0	0	0	1	0	0	0	13231	893	31	1	1203	1	RERE	1	8419925	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		8419925	240830696	1	22954										
DEM1	64789	broad.mit.edu	37	chr1	40980423	40980423	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tggaaaagaggattggatatAttatcacccatggagagatt	11	4	1	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:40980423A>G	uc001cfp.2	+	3	412	c.207A>G	c.(205-207)ATA>ATG	p.I69M	DEM1_uc001cfq.2_Missense_Mutation_p.I69M|DEM1_uc001cfr.2_Missense_Mutation_p.I69M|DEM1_uc001cfs.2_Missense_Mutation_p.I69M	NM_022774	NP_073611	Q9H790	EXO5_HUMAN	defects in morphology 1 homolog	69							DNA binding|exonuclease activity				0						GATTGGATATATTATCACCCA	0.423													0	0	0	0.004672	0	3	100										G	40980423	A	G	40980423	3	3	76	1	0	0	0	0	1	0	0	0	4425	439	16	5	209	5	DEM1	1	40980423	Missense_Mutation	SNP	A	TCGA-FD-A3B8-01A-31D-A20D-08	32560498	40980423	208270198	2	22955										
PI4KB	5298	broad.mit.edu	37	chr1	151288629	151288629	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ttgctcctttggctgtgcctGaggccacagcggcccccatc	11	16	0	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:151288629G>A	uc001ext.2	-	2	744	c.329C>T	c.(328-330)TCA>TTA	p.S110L	PI4KB_uc001exr.2_Missense_Mutation_p.S122L|PI4KB_uc001exs.2_Missense_Mutation_p.S110L|PI4KB_uc001exu.2_Missense_Mutation_p.S110L|PI4KB_uc010pcw.1_Intron|PI4KB_uc009wmq.1_Missense_Mutation_p.S122L	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	110					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGCTGTGCCTGAGGCCACAGC	0.542													0	0	0	0.058154	0	8	104										A	151288629	G	A	151288629	3	1	76	1	0	0	0	0	1	0	0	0	11874	1294	45	1	2165	1	PI4KB	1	151288629	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	110308206	151288629	97961992	3	22956										
FCGR2A	2212	broad.mit.edu	37	chr1	161487799	161487799	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aatgattgccatcagaaagaGacaacttgaagaaaccaaca	7	8	1	5			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:161487799G>C	uc001gan.2	+	7	868	c.815G>C	c.(814-816)AGA>ACA	p.R272T	FCGR2A_uc001gam.2_Missense_Mutation_p.R271T|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	272	Cytoplasmic (Potential).					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	atcagaaagagacaacttgaa	0.209													0	0	0	0.021553	0	6	64										C	161487799	G	C	161487799	3	2	76	1	0	0	0	0	1	0	0	0	5781	942	33	1	841	1	FCGR2A	1	161487799	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	10199170	161487799	87762822	4	22957										
ATF6	22926	broad.mit.edu	37	chr1	161821558	161821558	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aagccctgatggtgctaactGaagaaccattgctttacatt	8	9	0	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:161821558G>A	uc001gbr.2	+	11	1433	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	ATF6_uc001gbq.1_Missense_Mutation_p.E456K	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	456	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGTGCTAACTGAAGAACCATT	0.383													0	0	0	0.047766	0	7	208										A	161821558	G	A	161821558	3	1	76	1	0	0	0	0	1	0	0	0	1084	1291	45	1	1408	1	ATF6	1	161821558	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	333759	161821558	87429063	5	22958										
PAPPA2	60676	broad.mit.edu	37	chr1	176679172	176679172	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	atggcatatgtgaaccttttGagagaaaaaccagcattgta	9	6	0	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:176679172G>C	uc001gkz.2	+	11	4675	c.3511G>C	c.(3511-3513)GAG>CAG	p.E1171Q	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1171					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGAACCTTTTGAGAGAAAAAC	0.428													0	0	0	0.069234	0	8	128										C	176679172	G	C	176679172	3	2	76	1	0	0	0	0	1	0	0	0	11433	1291	45	1	3602	1	PAPPA2	1	176679172	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	14857614	176679172	72571449	6	22959										
SOAT1	6646	broad.mit.edu	37	chr1	179308589	179308589	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	acagtgaactgcttgaagtgGaccacatcagaacaatatat	8	8	1	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:179308589G>A	uc001gml.2	+	6	469	c.406G>A	c.(406-408)GAC>AAC	p.D136N	SOAT1_uc010pni.1_Missense_Mutation_p.D71N|SOAT1_uc001gmm.2_Missense_Mutation_p.D78N|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Missense_Mutation_p.D71N	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	136					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GCTTGAAGTGGACCACATCAG	0.313													0	0	0	0.038147	0	5	125										A	179308589	G	A	179308589	3	1	76	1	0	0	0	0	1	0	0	0	14910	1174	41	1	424	1	SOAT1	1	179308589	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	2629417	179308589	69942032	7	22960										
HEATR1	55127	broad.mit.edu	37	chr1	236766632	236766632	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	caacggtgcttcaaactgctCaaaggaaggatcaattccaa	8	10	3	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:236766632C>G	uc001hyd.1	-	3	312	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	HEATR1_uc001hye.1_Missense_Mutation_p.E63Q	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	63					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TCAAACTGCTCAAAGGAAGGA	0.393													0	0	0	0.004672	0	3	95										G	236766632	C	G	236766632	3	3	76	1	0	0	0	0	1	0	0	0	7027	835	29	1	6419	1	HEATR1	1	236766632	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	57458043	236766632	12483989	8	22961										
NEB	4703	broad.mit.edu	37	chr2	152543972	152543972	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gtcttcaaggagtgcagcatCtttggatcgtcattaatgct	10	8	4	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr2:152543972C>G	uc010fnx.2	-	27	2789	c.2598G>C	c.(2596-2598)AAG>AAC	p.K866N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	866	Nebulin 20.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGTGCAGCATCTTTGGATCGT	0.438													0	0	0	0.047766	0	8	178										G	152543972	C	G	152543972	3	3	76	1	0	0	0	0	1	0	0	0	10302	912	32	1	23712	1	NEB	2	152543972	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		152543972	90655401	9	22962										
TTN	7273	broad.mit.edu	37	chr2	179474565	179474565	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	accaggtgttcattgcatctCttccacctttcttcaccctt	4	15	4	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr2:179474565C>T	uc010zfg.1	-	221	44105	c.43881G>A	c.(43879-43881)AAG>AAA	p.K14627K	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K8322K|TTN_uc010zfi.1_Silent_p.K8255K|TTN_uc010zfj.1_Silent_p.K8130K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15554							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTGCATCTCTTCCACCTTT	0.473													0	0	0	0.020292	0	12	564										T	179474565	C	T	179474565	2	4	76	1	0	0	0	0	0	0	0	1	16732	912	32	1		1	TTN	2	179474565	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	26930593	179474565	63724808	10	22963										
GRM2	2912	broad.mit.edu	37	chr3	51749893	51749893	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tcgcctggctggtggtggagGcaccgggcacaggcaaggag	19	10	0	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:51749893G>A	uc010hlv.2	+	4	2343	c.2104G>A	c.(2104-2106)GCA>ACA	p.A702T	GRM2_uc003dbo.3_Missense_Mutation_p.A84T|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	702	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGTGGTGGAGGCACCGGGCAC	0.652													0	0	0	0.009096	0	3	44										A	51749893	G	A	51749893	3	1	76	1	0	0	0	0	1	0	0	0	6797	1203	42	2	2114	2	GRM2	3	51749893	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		51749893	146272537	11	22964										
NAALADL2	254827	broad.mit.edu	37	chr3	175293969	175293969	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gcttacgaggacatcaaaacAttagaggtgattgttcctaa	9	7	1	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:175293969A>G	uc003fit.2	+	10	1881	c.1794A>G	c.(1792-1794)ACA>ACG	p.T598T	NAALADL2_uc003fiu.1_Silent_p.T591T|NAALADL2_uc010hwy.1_Silent_p.T372T	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	598	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		ACATCAAAACATTAGAGGTGA	0.348													0	0	0	0.014758	0	5	175										G	175293969	A	G	175293969	2	3	76	1	0	0	0	0	0	0	0	1	10130	204	8	5		5	NAALADL2	3	175293969	Silent	SNP	A	TCGA-FD-A3B8-01A-31D-A20D-08	123544076	175293969	22728461	12	22965										
TP63	8626	broad.mit.edu	37	chr3	189455608	189455608	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cccagagcacacagacaaatGaattcctcagtccagaggtt	8	12	1	4			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:189455608G>A	uc003fry.2	+	2	231	c.142G>A	c.(142-144)GAA>AAA	p.E48K	TP63_uc003frx.2_Missense_Mutation_p.E48K|TP63_uc003frz.2_Missense_Mutation_p.E48K|TP63_uc010hzc.1_Missense_Mutation_p.E48K	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	48	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACAGACAAATGAATTCCTCAG	0.378									Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.009096	0	4	102										A	189455608	G	A	189455608	3	1	76	1	0	0	0	0	1	0	0	0	16389	1291	45	1	148	1	TP63	3	189455608	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	14161639	189455608	8566822	13	22966										
MFI2	4241	broad.mit.edu	37	chr3	196730882	196730882	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	caggcaccgcccggacggtgGcatccttgaaaagcaggtct	13	13	1	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:196730882G>A	uc003fxk.3	-	15	2140	c.2027C>T	c.(2026-2028)GCC>GTC	p.A676V	uc003fxi.2_5'Flank|uc003fxj.1_Intron	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	676	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CCGGACGGTGGCATCCTTGAA	0.587													0	0	0	0.049695	0	16	596										A	196730882	G	A	196730882	3	1	76	1	0	0	0	0	1	0	0	0	9522	1203	42	2	197	2	MFI2	3	196730882	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	7275274	196730882	1291548	14	22967										
OCIAD2	132299	broad.mit.edu	37	chr4	48894829	48894829	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	accagccccacggagctgatCttcaaaaaaatggaatttac	7	11	2	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr4:48894829C>G	uc003gyt.2	-	6	546	c.343G>C	c.(343-345)GAT>CAT	p.D115H	OCIAD2_uc003gyu.2_Intron	NM_001014446	NP_001014446	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2 isoform 1	115	OCIA.					endosome					0						CGGAGCTGATCTTCAAAAAAA	0.393													0	0	0	0.047766	0	7	330										G	48894829	C	G	48894829	3	3	76	1	0	0	0	0	1	0	0	0	10818	913	32	1	129	1	OCIAD2	4	48894829	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		48894829	142259447	15	22968										
SPRY1	10252	broad.mit.edu	37	chr4	124322883	124322883	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gtccttagaccagatcaaggCcataagaggcagcaatgaat	10	9	1	4			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr4:124322883C>A	uc003ifa.2	+	2	325	c.137C>A	c.(136-138)GCC>GAC	p.A46D	SPRY1_uc003ifb.2_Missense_Mutation_p.A46D	NM_199327	NP_955359	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling	46					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				skin(2)|ovary(1)	3						CAGATCAAGGCCATAAGAGGC	0.463													1	0	0.000602214	0.014758	0.000651809	5	182										A	124322883	C	A	124322883	3	1	76	1	0	0	0	0	1	0	0	0	15104	739	26	4	139	4	SPRY1	4	124322883	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	75428054	124322883	66831393	16	22969										
FAT4	79633	broad.mit.edu	37	chr4	126412493	126412493	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cattccagctccagaatcctCttctgatagtgactcccatg	6	14	2	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr4:126412493C>G	uc003ifj.3	+	17	14516	c.14516C>G	c.(14515-14517)TCT>TGT	p.S4839C	FAT4_uc011cgp.1_Missense_Mutation_p.S3080C|FAT4_uc003ifi.1_Missense_Mutation_p.S2316C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4839	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAGAATCCTCTTCTGATAGT	0.468													0	0	0	0.009096	0	4	86										G	126412493	C	G	126412493	3	3	76	1	0	0	0	0	1	0	0	0	5692	913	32	1	14582	1	FAT4	4	126412493	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	2089610	126412493	64741783	17	22970										
DNAH5	1767	broad.mit.edu	37	chr5	13729630	13729630	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tgtccaggatccattttgatGgttttggaggacaagcttta	11	6	0	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:13729630G>A	uc003jfd.2	-	69	11843	c.11801C>T	c.(11800-11802)CCA>CTA	p.P3934L	DNAH5_uc003jfc.2_Missense_Mutation_p.P102L	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3934					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCATTTTGATGGTTTTGGAGG	0.358									Kartagener_syndrome				0	0	0	0.009096	0	4	117										A	13729630	G	A	13729630	3	1	76	1	0	0	0	0	1	0	0	0	4604	1348	47	2	2117	2	DNAH5	5	13729630	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		13729630	167185630	18	22971										
DNAH5	1767	broad.mit.edu	37	chr5	13844961	13844961	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cgaaccttttcgtggaacttGacagatttaatgttgtcaaa	8	7	1	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:13844961G>C	uc003jfd.2	-	32	5298	c.5256C>G	c.(5254-5256)GTC>GTG	p.V1752V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1752	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGTGGAACTTGACAGATTTAA	0.468									Kartagener_syndrome				0	0	0	0.02938	0	6	237										C	13844961	G	C	13844961	2	2	76	1	0	0	0	0	0	0	0	1	4604	1277	45	1		1	DNAH5	5	13844961	Silent	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	115331	13844961	167070299	19	22972										
ADAMTS12	81792	broad.mit.edu	37	chr5	33588860	33588860	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cacagcacggttcgcttcttCtccccgtggggcccgcatgt	11	16	2	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:33588860C>T	uc003jia.1	-	18	2872	c.2709G>A	c.(2707-2709)GAG>GAA	p.E903E	ADAMTS12_uc010iuq.1_Silent_p.E818E	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	903	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTCGCTTCTTCTCCCCGTGGG	0.607										HNSCC(64;0.19)	OREG0016553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.049695	0	16	84										T	33588860	C	T	33588860	2	4	76	1	0	0	0	0	0	0	0	1	257	912	32	1		1	ADAMTS12	5	33588860	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	19743899	33588860	147326400	20	22973										
MSH3	4437	broad.mit.edu	37	chr5	79974807	79974807	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ccaggactctgcttctcgttCagagctagaaacccggatgt	10	12	3	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:79974807C>G	uc003kgz.2	+	8	1488	c.1235C>G	c.(1234-1236)TCA>TGA	p.S412*		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	412					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GCTTCTCGTTCAGAGCTAGAA	0.488								MMR					0	0	0	0.02938	0	6	224										G	79974807	C	G	79974807	4	3	76	1	0	0	0	0	0	1	0	0	9871	838	29	1	1265	1	MSH3	5	79974807	Nonsense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	46385947	79974807	100940453	21	22974										
LNPEP	4012	broad.mit.edu	37	chr5	96341855	96341855	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gatttcctttagtgactgttCaaaagaaaggaaaggaactt	9	5	1	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:96341855C>G	uc003kmv.1	+	10	2378	c.1864C>G	c.(1864-1866)CAA>GAA	p.Q622E	LNPEP_uc003kmw.1_Missense_Mutation_p.Q608E	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	622	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		AGTGACTGTTCAAAAGAAAGG	0.333													0	0	0	0.009096	0	3	69										G	96341855	C	G	96341855	3	3	76	1	0	0	0	0	1	0	0	0	8864	827	29	1	1902	1	LNPEP	5	96341855	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	16367048	96341855	84573405	22	22975										
PCDHA1	56147	broad.mit.edu	37	chr5	140167577	140167577	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	acgcgccggcgctgctggcgCctcgagtgggtggcactatt	16	13	0	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:140167577C>T	uc003lhb.2	+	1	1702	c.1702C>T	c.(1702-1704)CCT>TCT	p.P568S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.P568S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	568	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCTGGCGCCTCGAGTGGG	0.687													0	0	0	0.021553	0	6	107										T	140167577	C	T	140167577	3	4	76	1	0	0	0	0	1	0	0	0	11519	739	26	2	1704	2	PCDHA1	5	140167577	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	43825722	140167577	40747683	23	22976										
PCDHGA7	56108	broad.mit.edu	37	chr5	140762743	140762743	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ctgcgggcaggatagaccggGaagagatctgcgctcagagt	16	9	2	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:140762743G>A	uc003lka.1	+	1	277	c.277G>A	c.(277-279)GAA>AAA	p.E93K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.E93K	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	93	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAGACCGGGAAGAGATCTG	0.527													0	0	0	0.009096	0	4	93										A	140762743	G	A	140762743	3	1	76	1	0	0	0	0	1	0	0	0	11559	1175	41	1	279	1	PCDHGA7	5	140762743	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	595166	140762743	40152517	24	22977										
GNB2L1	10399	broad.mit.edu	37	chr5	180668594	180668594	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tcagaggagaaggccacactCagcacatccttggtatggcc	11	12	2	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:180668594C>G	uc003mni.1	-	3	433	c.327G>C	c.(325-327)CTG>CTC	p.L109L	GNB2L1_uc003mnh.1_Silent_p.L68L|GNB2L1_uc003mnk.1_Silent_p.L31L|GNB2L1_uc003mnj.1_Silent_p.L63L|GNB2L1_uc003mnl.1_5'UTR|GNB2L1_uc011dhk.1_Silent_p.L109L|GNB2L1_uc010jls.2_Silent_p.L68L|GNB2L1_uc011dhl.1_Silent_p.L109L	NM_006098	NP_006089	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein),	109	WD 3.			Missing (in Ref. 4; BAG53102).	apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		AGGCCACACTCAGCACATCCT	0.507													0	0	0	0.021553	0	5	98										G	180668594	C	G	180668594	2	3	76	1	0	0	0	0	0	0	0	1	6518	813	29	1		1	GNB2L1	5	180668594	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	39905851	180668594	246666	25	22978										
TNXB	7148	broad.mit.edu	37	chr6	32015700	32015700	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gaaggagtcgaattcgccctCagggaccgtccacgagaggc	14	12	1	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr6:32015700C>T	uc003nzl.2	-	30	10331	c.10129G>A	c.(10129-10131)GAG>AAG	p.E3377K	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3424	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AATTCGCCCTCAGGGACCGTC	0.637													0	0	0	0.009096	0	4	59										T	32015700	C	T	32015700	3	4	76	1	0	0	0	0	1	0	0	0	16343	835	29	1	4644	1	TNXB	6	32015700	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		32015700	139099367	26	22979										
FANCE	2178	broad.mit.edu	37	chr6	35426085	35426085	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tgtaagcagatggacttgctGtgtgcccagctgcagctccc	12	12	0	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr6:35426085G>T	uc003oko.1	+	5	1166	c.981G>T	c.(979-981)CTG>CTT	p.L327L	FANCE_uc010jvw.1_Intron	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	327	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						TGGACTTGCTGTGTGCCCAGC	0.602			N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	1.5842e-08	0.105934	1.84489e-08	13	186										T	35426085	G	T	35426085	2	4	76	1	0	0	0	0	0	0	0	1	5666	1364	48	4		4	FANCE	6	35426085	Silent	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	3410385	35426085	135688982	27	22980										
DNAH8	1769	broad.mit.edu	37	chr6	38834595	38834595	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ggttttcttgaaaatgttatCttggctcaaaaattttacgt	7	5	3	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr6:38834595C>G	uc003ooe.1	+	45	6585	c.5985C>G	c.(5983-5985)ATC>ATG	p.I1995M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAAATGTTATCTTGGCTCAAA	0.303													0	0	0	0.02938	0	5	47										G	38834595	C	G	38834595	3	3	76	1	0	0	0	0	1	0	0	0	4607	903	32	1	6155	1	DNAH8	6	38834595	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	3408510	38834595	132280472	28	22981										
PURB	5814	broad.mit.edu	37	chr7	44924329	44924329	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gccccctgggcccccggcgcCgcctcccgggccgcctgcca	13	24	0	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:44924329C>T	uc003tme.2	-	1	632	c.619G>A	c.(619-621)GGC>AGC	p.G207S		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	207	Gly-rich.|By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						cccccggcgccgcctcccggg	0.502													0	0	0	0.004672	0	3	38										T	44924329	C	T	44924329	3	4	76	1	0	0	0	0	1	0	0	0	12828	652	23	2	323	2	PURB	7	44924329	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		44924329	114214334	29	22982										
FZD9	8326	broad.mit.edu	37	chr7	72849103	72849103	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ctgtgctcaccttcttgctgGagccccaccgcttccagtac	8	17	2	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:72849103G>C	uc003tyb.2	+	1	995	c.766G>C	c.(766-768)GAG>CAG	p.E256Q		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	256	Cytoplasmic (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTTCTTGCTGGAGCCCCACCG	0.642													0	0	0	0.021553	0	5	188										C	72849103	G	C	72849103	3	2	76	1	0	0	0	0	1	0	0	0	6137	1175	41	1	768	1	FZD9	7	72849103	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	27924774	72849103	86289560	30	22983										
CYP3A4	1576	broad.mit.edu	37	chr7	99366067	99366067	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ttgtggattgttgagagagtCgatgttcactccaaatgatg	12	5	1	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:99366067C>T	uc003urv.1	-	7	684	c.580G>A	c.(580-582)GAC>AAC	p.D194N	CYP3A4_uc003urw.1_Missense_Mutation_p.D194N|CYP3A4_uc011kiz.1_Missense_Mutation_p.D153N|CYP3A4_uc011kja.1_Missense_Mutation_p.D145N|CYP3A4_uc011kjb.1_Missense_Mutation_p.D44N	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	194					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTGAGAGAGTCGATGTTCACT	0.403													0	0	0	0.014758	0	5	144										T	99366067	C	T	99366067	3	4	76	1	0	0	0	0	1	0	0	0	4178	884	31	1	959	1	CYP3A4	7	99366067	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	26516964	99366067	59772596	31	22984										
C7orf58	79974	broad.mit.edu	37	chr7	120740099	120740099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tttgcgtgcattcattcattCgacgggcacagtttggaatc	10	9	2	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:120740099C>T	uc003vjq.3	+	7	1316	c.869C>T	c.(868-870)TCG>TTG	p.S290L	C7orf58_uc003vjr.1_Missense_Mutation_p.S290L|C7orf58_uc003vjs.3_Missense_Mutation_p.S290L|C7orf58_uc003vjt.3_Missense_Mutation_p.S70L|C7orf58_uc010lkk.1_Missense_Mutation_p.S70L	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	290						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTCATTCATTCGACGGGCACA	0.428													0	0	0	0.047766	0	7	64										T	120740099	C	T	120740099	3	4	76	1	0	0	0	0	1	0	0	0	2405	893	31	1	891	1	C7orf58	7	120740099	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	21374032	120740099	38398564	32	22985										
CADPS2	93664	broad.mit.edu	37	chr7	122033257	122033257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gaggaatacacacgtggactCatataaagaaggcatccacg	10	9	1	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:122033257C>G	uc010lkp.2	-	21	3164	c.3001G>C	c.(3001-3003)GAG>CAG	p.E1001Q	CADPS2_uc011knx.1_Missense_Mutation_p.E376Q|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1001	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CACGTGGACTCATATAAAGAA	0.458													0	0	0	0.004672	0	3	36										G	122033257	C	G	122033257	3	3	76	1	0	0	0	0	1	0	0	0	2571	835	29	1	944	1	CADPS2	7	122033257	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	1293158	122033257	37105406	33	22986										
CPA4	51200	broad.mit.edu	37	chr7	129945685	129945685	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gggaaaggcgtgaggcggccGgccgtttggctgaatgcagg	20	8	0	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:129945685G>A	uc003vpr.2	+	6	563	c.516G>A	c.(514-516)CCG>CCA	p.P172P	CPA4_uc011kpd.1_Silent_p.P139P|CPA4_uc011kpe.1_Silent_p.P68P	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	172					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TGAGGCGGCCGGCCGTTTGGC	0.587													0	0	0	0.038147	0	6	140										A	129945685	G	A	129945685	2	1	76	1	0	0	0	0	0	0	0	1	3792	1103	39	2		2	CPA4	7	129945685	Silent	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	7912428	129945685	29192978	34	22987										
KRBA1	84626	broad.mit.edu	37	chr7	149425660	149425660	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cagggtctggagaattgtctCaaggagatacctgtgcctgt	13	8	2	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:149425660C>G	uc003wfz.2	+	12	1920	c.1521C>G	c.(1519-1521)CTC>CTG	p.L507L	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.L175L	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	507										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGAATTGTCTCAAGGAGATAC	0.577													0	0	0	0.047766	0	7	221										G	149425660	C	G	149425660	2	3	76	1	0	0	0	0	0	0	0	1	8439	813	29	1		1	KRBA1	7	149425660	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	19479975	149425660	9713003	35	22988										
ASAH1	427	broad.mit.edu	37	chr8	17918895	17918895	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aaacactttaccttgtgctaTtttccagaactgttctagtg	6	9	1	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr8:17918895T>C	uc003wyl.2	-	10	1088	c.776A>G	c.(775-777)AAT>AGT	p.N259S	ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_Missense_Mutation_p.N234S|ASAH1_uc003wyn.2_Missense_Mutation_p.N275S|ASAH1_uc003wyo.2_Missense_Mutation_p.N253S	NM_177924	NP_808592	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase 1 isoform a	259					ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		CCTTGTGCTATTTTCCAGAAC	0.313													0	0	0	0.014758	0	4	133										C	17918895	T	C	17918895	3	2	76	1	0	0	0	0	1	0	0	0	1006	1493	52	5	431	5	ASAH1	8	17918895	Missense_Mutation	SNP	T	TCGA-FD-A3B8-01A-31D-A20D-08		17918895	128445127	36	22989										
ANK1	286	broad.mit.edu	37	chr8	41573364	41573364	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	acagtgaagtggggtctggtCatcctggaccccgaagggaa	15	9	2	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr8:41573364C>T	uc003xok.2	-	14	1492	c.1408G>A	c.(1408-1410)GAC>AAC	p.D470N	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.D470N|ANK1_uc003xoj.2_Missense_Mutation_p.D470N|ANK1_uc003xol.2_Missense_Mutation_p.D470N|ANK1_uc003xom.2_Missense_Mutation_p.D503N	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	470	ANK 14.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGGGTCTGGTCATCCTGGACC	0.373													0	0	0	0.021553	0	4	50										T	41573364	C	T	41573364	3	4	76	1	0	0	0	0	1	0	0	0	620	826	29	1	4707	1	ANK1	8	41573364	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	23654469	41573364	104790658	37	22990										
KCNB2	9312	broad.mit.edu	37	chr8	73849986	73849986	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	actgttccctttctcttcaaGagagaggaggagcttcactg	10	10	3	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr8:73849986G>C	uc003xzb.2	+	3	2984	c.2396G>C	c.(2395-2397)AGA>ACA	p.R799T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	799	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTCTCTTCAAGAGAGAGGAGG	0.542													0	0	0	0.014758	0	3	37										C	73849986	G	C	73849986	3	2	76	1	0	0	0	0	1	0	0	0	8013	942	33	1	2402	1	KCNB2	8	73849986	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	32276622	73849986	72514036	38	22991										
NAA35	60560	broad.mit.edu	37	chr9	88557196	88557196	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	agattttgaagaagcttgtcGaggtgagtctgatttttgga	13	3	1	5			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:88557196G>A	uc004aoi.3	+	2	259	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	NAA35_uc004aoj.3_Missense_Mutation_p.R41Q|NAA35_uc004aok.1_Missense_Mutation_p.R41Q	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	41					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						GAAGCTTGTCGAGGTGAGTCT	0.403													0	0	0	0.069234	0	7	176										A	88557196	G	A	88557196	3	1	76	1	0	0	0	0	1	0	0	0	10123	1058	37	1	124	1	NAA35	9	88557196	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		88557196	52656235	39	22992										
OR13F1	138805	broad.mit.edu	37	chr9	107267011	107267011	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	atgacaggctgtctcactgcCatggtggaaatgatgtctgt	12	8	2	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:107267011C>G	uc011lvm.1	+	1	468	c.468C>G	c.(466-468)GCC>GCG	p.A156A		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						GTCTCACTGCCATGGTGGAAA	0.478													0	0	0	0.038147	0	5	129										G	107267011	C	G	107267011	2	3	76	1	0	0	0	0	0	0	0	1	10941	581	21	4		4	OR13F1	9	107267011	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	18709815	107267011	33946420	40	22993										
CERCAM	51148	broad.mit.edu	37	chr9	131186476	131186476	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ctgcggcttctcatggggcaGgggcttccagtggtggcccc	16	13	1	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:131186476G>C	uc004buz.3	+	4	884	c.486G>C	c.(484-486)CAG>CAC	p.Q162H	CERCAM_uc004buy.1_Missense_Mutation_p.Q84H|CERCAM_uc010mxz.2_Missense_Mutation_p.Q84H|CERCAM_uc010mya.1_Missense_Mutation_p.Q3H	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	162					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						TCATGGGGCAGGGGCTTCCAG	0.612													0	0	0	0.02938	0	6	146										C	131186476	G	C	131186476	3	2	76	1	0	0	0	0	1	0	0	0	3266	991	35	4	500	4	CERCAM	9	131186476	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	23919465	131186476	10026955	41	22994										
SEC16A	9919	broad.mit.edu	37	chr9	139369336	139369336	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aaaccatttcggaagcaccaGaaccttgtggaaaattactt	7	9	0	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:139369336G>T	uc004chx.2	-	3	3041	c.2732C>A	c.(2731-2733)TCT>TAT	p.S911Y	SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Missense_Mutation_p.S911Y|SEC16A_uc010nbn.2_Missense_Mutation_p.S911Y|SEC16A_uc010nbo.1_Missense_Mutation_p.S911Y	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	733					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGAAGCACCAGAACCTTGTGG	0.468													1	0	5.9392e-07	0.021553	6.74576e-07	5	93										T	139369336	G	T	139369336	3	4	76	1	0	0	0	0	1	0	0	0	13986	942	33	3	4461	3	SEC16A	9	139369336	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	8182860	139369336	1844095	42	22995										
KIAA1217	56243	broad.mit.edu	37	chr10	24762442	24762442	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gagatgtcaagcctgatgaaGacatgagtggcaaaaacatt	11	6	1	5			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr10:24762442G>A	uc001iru.3	+	6	1535	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	KIAA1217_uc001irs.2_Missense_Mutation_p.D298N|KIAA1217_uc001irt.3_Missense_Mutation_p.D378N|KIAA1217_uc010qcy.1_Missense_Mutation_p.D378N|KIAA1217_uc010qcz.1_Missense_Mutation_p.D378N|KIAA1217_uc001irv.1_Missense_Mutation_p.D228N|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.D96N|KIAA1217_uc001irz.2_Missense_Mutation_p.D96N|KIAA1217_uc001irx.2_Missense_Mutation_p.D96N|KIAA1217_uc001iry.2_Missense_Mutation_p.D96N	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	378					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GCCTGATGAAGACATGAGTGG	0.493													0	0	0	0.038147	0	7	161										A	24762442	G	A	24762442	3	1	76	1	0	0	0	0	1	0	0	0	8216	942	33	1	1154	1	KIAA1217	10	24762442	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		24762442	110772305	43	22996										
ANO9	338440	broad.mit.edu	37	chr11	431763	431763	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	acgtcttcttcaggcgtcccTccccctggctcgggtgacag	11	16	3	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:431763T>C	uc001lpi.2	-	7	555	c.470A>G	c.(469-471)GAG>GGG	p.E157G	ANO9_uc001lph.2_5'Flank|ANO9_uc010qvv.1_Missense_Mutation_p.E13G	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	157	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CAGGCGTCCCTCCCCCTGGCT	0.647													0	0	0	0.004672	0	3	57										C	431763	T	C	431763	3	2	76	1	0	0	0	0	1	0	0	0	704	1551	54	5	1946	5	ANO9	11	431763	Missense_Mutation	SNP	T	TCGA-FD-A3B8-01A-31D-A20D-08		431763	134574753	44	22997										
GANAB	23193	broad.mit.edu	37	chr11	62407194	62407194	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aaaaaagccagtaccaaagaCgcccaagacctaaggagaaa	8	10	0	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:62407194C>G	uc001nub.2	-	2	81	c.48G>C	c.(46-48)GCG>GCC	p.A16A	GANAB_uc001nua.2_Silent_p.A16A|GANAB_uc001nuc.2_5'UTR|GANAB_uc010rma.1_Intron|GANAB_uc010rmb.1_Intron	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	16					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GTACCAAAGACGCCCAAGACC	0.473													0	0	0	0.004672	0	3	89										G	62407194	C	G	62407194	2	3	76	1	0	0	0	0	0	0	0	1	6233	523	19	4		4	GANAB	11	62407194	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	61975431	62407194	72599322	45	22998										
PCF11	51585	broad.mit.edu	37	chr11	82877510	82877510	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	agctggaaagattcgccaatCtggagctaagcagtcacata	10	9	2	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:82877510C>G	uc001ozx.3	+	5	1916	c.1571C>G	c.(1570-1572)TCT>TGT	p.S524C	PCF11_uc010rsu.1_Missense_Mutation_p.S524C	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	524					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATTCGCCAATCTGGAGCTAAG	0.443													0	0	0	0.02938	0	6	140										G	82877510	C	G	82877510	3	3	76	1	0	0	0	0	1	0	0	0	11573	913	32	1	1589	1	PCF11	11	82877510	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	20470316	82877510	52129006	46	22999										
SIK2	23235	broad.mit.edu	37	chr11	111558730	111558730	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tctcttcatttacagactatCttgctaatcatggccggtta	6	10	4	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:111558730C>G	uc001plt.2	+	4	440	c.322C>G	c.(322-324)CTT>GTT	p.L108V		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	108	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						TACAGACTATCTTGCTAATCA	0.368													0	0	0	0.021553	0	4	91										G	111558730	C	G	111558730	3	3	76	1	0	0	0	0	1	0	0	0	14318	913	32	1	336	1	SIK2	11	111558730	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	28681220	111558730	23447786	47	23000										
KDM5A	5927	broad.mit.edu	37	chr12	417057	417057	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	actggctgtcttgcggcaaaTgcaaaattttacttcttcta	7	9	3	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr12:417057T>C	uc001qif.1	-	23	3856	c.3493A>G	c.(3493-3495)ATT>GTT	p.I1165V	KDM5A_uc001qie.1_Missense_Mutation_p.I1165V	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1165	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TTGCGGCAAATGCAAAATTTT	0.453			T 	NUP98	AML								0	0	0	0.038147	0	7	163										C	417057	T	C	417057	3	2	76	1	0	0	0	0	1	0	0	0	8133	1464	51	5	1603	5	KDM5A	12	417057	Missense_Mutation	SNP	T	TCGA-FD-A3B8-01A-31D-A20D-08		417057	133434838	48	23001										
DDX23	9416	broad.mit.edu	37	chr12	49230553	49230553	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cagcgctgcttggcttccttCttacgaagtttgcggagtct	11	11	2	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr12:49230553C>G	uc001rsm.2	-	10	1126	c.1035G>C	c.(1033-1035)AAG>AAC	p.K345N		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	345						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TGGCTTCCTTCTTACGAAGTT	0.532													0	0	0	0.069234	0	10	236										G	49230553	C	G	49230553	3	3	76	1	0	0	0	0	1	0	0	0	4350	912	32	1	1459	1	DDX23	12	49230553	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	48813496	49230553	84621342	49	23002										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100476855	100476855	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tagacattagcttagcttttGattgttgagataatactgaa	8	4	0	4			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr12:100476855G>C	uc001tgq.2	-	11	1575	c.1346C>G	c.(1345-1347)TCA>TGA	p.S449*	UHRF1BP1L_uc001tgr.2_Nonsense_Mutation_p.S449*|UHRF1BP1L_uc001tgp.2_Nonsense_Mutation_p.S99*	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	449										ovary(2)	2						CTTAGCTTTTGATTGTTGAGA	0.338													0	0	0	0.014758	0	4	81										C	100476855	G	C	100476855	4	2	76	1	0	0	0	0	0	1	0	0	16966	1294	45	1	3116	1	UHRF1BP1L	12	100476855	Nonsense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	51246302	100476855	33375040	50	23003										
SACS	26278	broad.mit.edu	37	chr13	23905175	23905175	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ttgtggctctctctaccagaGaaaagaggaggaatgcttct	11	8	3	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr13:23905175G>C	uc001uon.2	-	10	13429	c.12840C>G	c.(12838-12840)TTC>TTG	p.F4280L	SACS_uc001uoo.2_Missense_Mutation_p.F4133L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4280					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTCTACCAGAGAAAAGAGGAG	0.478													0	0	0	0.014758	0	4	93										C	23905175	G	C	23905175	3	2	76	1	0	0	0	0	1	0	0	0	13804	933	33	1	903	1	SACS	13	23905175	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		23905175	91264703	51	23004										
CDK8	1024	broad.mit.edu	37	chr13	26911762	26911762	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gaactgggatctctatgtcgGcatgtagagaaatagcagta	12	6	1	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr13:26911762G>A	uc001uqr.1	+	2	213	c.187G>A	c.(187-189)GCA>ACA	p.A63T	CDK8_uc001uqs.1_Missense_Mutation_p.A63T|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	63	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CTCTATGTCGGCATGTAGAGA	0.284													0	0	0	0.02938	0	4	138										A	26911762	G	A	26911762	3	1	76	1	0	0	0	0	1	0	0	0	3150	1203	42	2	193	2	CDK8	13	26911762	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	3006587	26911762	88258116	52	23005										
PAN3	255967	broad.mit.edu	37	chr13	28794450	28794450	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cgtgtcccagtcaaatatgtCtgccttctctcaagttttct	6	12	5	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr13:28794450C>T	uc001urz.2	+	5	505	c.497C>T	c.(496-498)TCT>TTT	p.S166F	PAN3_uc010tdo.1_Missense_Mutation_p.S312F|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Missense_Mutation_p.S112F	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	312	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TCAAATATGTCTGCCTTCTCT	0.438													0	0	0	0.038147	0	8	308										T	28794450	C	T	28794450	3	4	76	1	0	0	0	0	1	0	0	0	11415	913	32	1	957	1	PAN3	13	28794450	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	1882688	28794450	86375428	53	23006										
NFKBIA	4792	broad.mit.edu	37	chr14	35871254	35871254	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ctggcctccaaacacacagtCatcatagggcagctgaaaac	8	13	2	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr14:35871254C>T	uc001wtf.3	-	6	1029	c.919G>A	c.(919-921)GAC>AAC	p.D307N	NFKBIA_uc001wte.3_Missense_Mutation_p.D217N|NFKBIA_uc001wtg.3_Missense_Mutation_p.D264N|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	307					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		AACACACAGTCATCATAGGGC	0.453													0	0	0	0.028581	0	13	126										T	35871254	C	T	35871254	3	4	76	1	0	0	0	0	1	0	0	0	10377	826	29	1	38	1	NFKBIA	14	35871254	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		35871254	71478286	54	23007										
LRFN5	145581	broad.mit.edu	37	chr14	42356424	42356424	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ccatttgcacaagatgactcGgttagatgtgacatcaaata	8	8	1	4			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr14:42356424G>A	uc001wvm.2	+	3	1794	c.596G>A	c.(595-597)CGG>CAG	p.R199Q	LRFN5_uc010ana.2_Missense_Mutation_p.R199Q	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	199	Extracellular (Potential).|LRR 7.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AAGATGACTCGGTTAGATGTG	0.438										HNSCC(30;0.082)			0	0	0	0.014758	0	4	31										A	42356424	G	A	42356424	3	1	76	1	0	0	0	0	1	0	0	0	8941	1116	39	2	598	2	LRFN5	14	42356424	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	6485170	42356424	64993116	55	23008										
FAM161B	145483	broad.mit.edu	37	chr14	74401048	74401048	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aggctgttctagagatccttCtaaaccctgctctggatctc	8	12	4	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr14:74401048C>G	uc001xpd.1	-	9	1961	c.1855G>C	c.(1855-1857)GAA>CAA	p.E619Q		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						AGAGATCCTTCTAAACCCTGC	0.373													0	0	0	0.038147	0	6	100										G	74401048	C	G	74401048	3	3	76	1	0	0	0	0	1	0	0	0	5473	922	32	1	92	1	FAM161B	14	74401048	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	32044624	74401048	32948492	56	23009										
ATP10A	57194	broad.mit.edu	37	chr15	25953415	25953415	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gtaattctgagttttgctccGaatctttttttgatgcctcc	7	9	2	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:25953415G>C	uc010ayu.2	-	11	2483	c.2377C>G	c.(2377-2379)CGG>GGG	p.R793G		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	793	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.R793W(1)		pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GTTTTGCTCCGAATCTTTTTT	0.537													0	0	0	0.014758	0	4	121										C	25953415	G	C	25953415	3	2	76	1	0	0	0	0	1	0	0	0	1116	1057	37	1	2166	1	ATP10A	15	25953415	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		25953415	76577977	57	23010										
NDUFAF1	51103	broad.mit.edu	37	chr15	41689076	41689076	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	caacttctttctggtgatctCcttgcaaatccccttcagtc	5	14	4	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:41689076C>A	uc001znx.2	-	2	564	c.182G>T	c.(181-183)GGA>GTA	p.G61V	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	61					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		CTGGTGATCTCCTTGCAAATC	0.423													1	0	0.000442599	0.058154	0.000484752	7	205										A	41689076	C	A	41689076	3	1	76	1	0	0	0	0	1	0	0	0	10274	855	30	3	817	3	NDUFAF1	15	41689076	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	15735661	41689076	60842316	58	23011										
NOX5	79400	broad.mit.edu	37	chr15	69328242	69328242	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cctcctcatgttcatctgctCcagttcctgcatccgcagga	7	16	3	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:69328242C>G	uc002ars.1	+	7	1174	c.1154C>G	c.(1153-1155)TCC>TGC	p.S385C	NOX5_uc002arp.1_Missense_Mutation_p.S367C|NOX5_uc002arq.1_Missense_Mutation_p.S339C|NOX5_uc010bid.1_Missense_Mutation_p.S350C|NOX5_uc002arr.1_Missense_Mutation_p.S357C|NOX5_uc010bie.1_Missense_Mutation_p.S185C|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	385	Ferric oxidoreductase.|Cytoplasmic (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TTCATCTGCTCCAGTTCCTGC	0.597													0	0	0	0.02938	0	6	185										G	69328242	C	G	69328242	3	3	76	1	0	0	0	0	1	0	0	0	10559	855	30	1	1213	1	NOX5	15	69328242	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	27639166	69328242	33203150	59	23012										
FAM169B	283777	broad.mit.edu	37	chr15	98995216	98995216	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aggcagcaggtagcatgcacCggtgccatcaccacacagtc	11	14	1	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:98995216C>T	uc002buk.1	-	5	458	c.208G>A	c.(208-210)GGT>AGT	p.G70S		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	70											0						TAGCATGCACCGGTGCCATCA	0.592													0	0	0	0.004672	0	3	63										T	98995216	C	T	98995216	3	4	76	1	0	0	0	0	1	0	0	0	5488	652	23	2	382	2	FAM169B	15	98995216	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	29666974	98995216	3536176	60	23013										
NEURL4	84461	broad.mit.edu	37	chr17	7230206	7230206	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gagaatgggcgaggtggcagCaccgctagatcccaggcctt	15	11	0	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:7230206C>A	uc002gga.1	-	4	923	c.916G>T	c.(916-918)GCT>TCT	p.A306S	NEURL4_uc002ggb.1_Missense_Mutation_p.A306S|NEURL4_uc002ggc.1_5'UTR	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	306							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GAGGTGGCAGCACCGCTAGAT	0.562													1	0	8.12818e-05	0.02938	9.00955e-05	5	91										A	7230206	C	A	7230206	3	1	76	1	0	0	0	0	1	0	0	0	10347	710	25	4	3876	4	NEURL4	17	7230206	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08		7230206	73965004	61	23014										
TP53	7157	broad.mit.edu	37	chr17	7578419	7578419	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ggggcagcgcctcacaacctCcgtcatgtgctgtgactgct	12	14	2	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:7578419C>A	uc002gim.2	-	5	705	c.511G>T	c.(511-513)GAG>TAG	p.E171*	TP53_uc002gig.1_Nonsense_Mutation_p.E171*|TP53_uc002gih.2_Nonsense_Mutation_p.E171*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E39*|TP53_uc010cng.1_Nonsense_Mutation_p.E39*|TP53_uc002gii.1_Nonsense_Mutation_p.E39*|TP53_uc010cnh.1_Nonsense_Mutation_p.E171*|TP53_uc010cni.1_Nonsense_Mutation_p.E171*|TP53_uc002gij.2_Nonsense_Mutation_p.E171*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.E78*|TP53_uc002gio.2_Nonsense_Mutation_p.E39*|TP53_uc010vug.1_Nonsense_Mutation_p.E132*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	171	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E171*(10)|p.E171K(8)|p.0?(7)|p.E171G(3)|p.E171Q(3)|p.E171fs*10(3)|p.E171fs*3(2)|p.E171V(2)|p.E171D(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.E171fs*9(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.E171_V172delEV(1)|p.H168fs*69(1)|p.T170_E171insXX(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.E171A(1)|p.H168fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCACAACCTCCGTCATGTGC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	5.9392e-07	0.021553	6.74576e-07	5	75										A	7578419	C	A	7578419	4	1	76	1	0	0	0	0	0	1	0	0	16378	864	30	3	787	3	TP53	17	7578419	Nonsense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	348213	7578419	73616791	62	23015										
C17orf48	56985	broad.mit.edu	37	chr17	10608569	10608569	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tccagttcatcatacatgggGaaaccatgaattctataact	6	9	3	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:10608569G>A	uc002gmt.2	+	2	401	c.326G>A	c.(325-327)GGA>GAA	p.G109E	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Missense_Mutation_p.G109E	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	109							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						CATACATGGGGAAACCATGAA	0.358													0	0	0	0.02938	0	5	77										A	10608569	G	A	10608569	3	1	76	1	0	0	0	0	1	0	0	0	1859	1174	41	1	328	1	C17orf48	17	10608569	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	3030150	10608569	70586641	63	23016										
ITGA2B	3674	broad.mit.edu	37	chr17	42458417	42458417	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tgggacccccgtagggggcaGccactgcaatgtctggaagg	16	11	1	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:42458417G>A	uc002igt.1	-	13	1255	c.1223C>T	c.(1222-1224)GCT>GTT	p.A408V	ITGA2B_uc002igu.1_5'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	408	Extracellular (Potential).|FG-GAP 6.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GTAGGGGGCAGCCACTGCAAT	0.577													0	0	0	0.014758	0	3	43										A	42458417	G	A	42458417	3	1	76	1	0	0	0	0	1	0	0	0	7876	971	34	2	1968	2	ITGA2B	17	42458417	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	31849848	42458417	38736793	64	23017										
TBX4	9496	broad.mit.edu	37	chr17	59560439	59560439	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tactcaggttcagggcccgaGattgccggggtgtctggggt	17	9	3	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:59560439G>A	uc002izi.2	+	8	1245	c.1200G>A	c.(1198-1200)GAG>GAA	p.E400E	TBX4_uc010ddo.2_Silent_p.E401E|TBX4_uc010woy.1_Silent_p.E401E	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	400					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CAGGGCCCGAGATTGCCGGGG	0.607													0	0	0	0.047766	0	8	90										A	59560439	G	A	59560439	2	1	76	1	0	0	0	0	0	0	0	1	15657	933	33	1		1	TBX4	17	59560439	Silent	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	17102022	59560439	21634771	65	23018										
CAPN12	147968	broad.mit.edu	37	chr19	39226178	39226178	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tctgcgctgatcacgtcgtcGatctccctgcaaattacaga	8	13	3	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr19:39226178G>T	uc002ojd.1	-	13	1899	c.1590C>A	c.(1588-1590)ATC>ATA	p.I530I	CAPN12_uc010egd.1_5'Flank|CAPN12_uc002ojc.1_5'UTR	NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	530	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			TCACGTCGTCGATCTCCCTGC	0.632													1	0	1.23904e-05	0.014758	1.39014e-05	5	34										T	39226178	G	T	39226178	2	4	76	1	0	0	0	0	0	0	0	1	2625	1048	37	3		3	CAPN12	19	39226178	Silent	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		39226178	19902805	66	23019										
TPRX1	284355	broad.mit.edu	37	chr19	48305091	48305091	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	attcacagagccaccctcctCttggggctgagaccctgagt	10	14	2	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr19:48305091C>G	uc002php.1	-	2	1248	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	393						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		CCACCCTCCTCTTGGGGCTGA	0.532													0	0	0	0.021553	0	6	173										G	48305091	C	G	48305091	3	3	76	1	0	0	0	0	1	0	0	0	16419	922	32	1	62	1	TPRX1	19	48305091	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	9078913	48305091	10823892	67	23020										
C20orf70	140683	broad.mit.edu	37	chr20	31757018	31757018	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ggacctcagagtctcttcttGacaatcttggcaatgaccta	8	11	4	3			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr20:31757018G>C	uc002wyo.1	+	2	138	c.67G>C	c.(67-69)GAC>CAC	p.D23H		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	23						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						GTCTCTTCTTGACAATCTTGG	0.463													0	0	0	0.009096	0	4	186										C	31757018	G	C	31757018	3	2	76	1	0	0	0	0	1	0	0	0	2116	1290	45	1	69	1	C20orf70	20	31757018	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		31757018	31268502	68	23021										
CECR2	27443	broad.mit.edu	37	chr22	17976598	17976598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	attaccggctggatgcagacGatgtcttcgatcttctaaag	10	9	3	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:17976598G>A	uc010gqw.1	+	2	385	c.259G>A	c.(259-261)GAT>AAT	p.D87N	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	129					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GGATGCAGACGATGTCTTCGA	0.512													0	0	0	0.014758	0	4	125										A	17976598	G	A	17976598	3	1	76	1	0	0	0	0	1	0	0	0	3206	1058	37	1	267	1	CECR2	22	17976598	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		17976598	33327968	69	23022										
EP300	2033	broad.mit.edu	37	chr22	41545867	41545867	+	Missense_Mutation	SNP	C	C	T													0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	agcttcctcaaccagctcttCatcagaattcaccctcgcct							TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:41545867C>T	uc003azl.3	+	14	2877	c.2482C>T	c.(2482-2484)CAT>TAT	p.H828Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	828					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ACCAGCTCTTCATCAGAATTC	0.552			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.021553	0	4	58										T	41545867	C	T	41545867	3	4	76	1	0	0	0	0	1	0	0	0	5148	826	29	1	2536	1	EP300	22	41545867	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	23569269	41545867	9758699	70	23023	115	2								
EP300	2033	broad.mit.edu	37	chr22	41545870	41545870	+	Nonsense_Mutation	SNP	C	C	T													0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ttcctcaaccagctcttcatCagaattcaccctcgcctgta							TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:41545870C>T	uc003azl.3	+	14	2880	c.2485C>T	c.(2485-2487)CAG>TAG	p.Q829*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	829					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGCTCTTCATCAGAATTCACC	0.562			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.021553	0	4	59										T	41545870	C	T	41545870	4	4	76	1	0	0	0	0	0	1	0	0	5148	827	29	1	2539	1	EP300	22	41545870	Nonsense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	3	41545870	9758696	71	23024	115	2								
PANX2	56666	broad.mit.edu	37	chr22	50616632	50616633	+	Frame_Shift_Del	DEL	TG	TG	-													0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	ccgggccccggccccgccccTgcccccgccccgccgcccgc							TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:50616632_50616633delTG	uc003bjn.3	+	2	1491_1492	c.1491_1492delTG	c.(1489-1494)CCTGCCfs	p.P497fs	PANX2_uc003bjp.3_Frame_Shift_Del_p.P363fs|PANX2_uc003bjo.3_Frame_Shift_Del_p.P497fs	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	497_498	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		gccccgcccctgcccccgcccc	0.554																		3	5	---	---								-	50616633	TG	-	50616632	7	5	76	1	0	1	0	1	0	0	0	0	11421	1567	55	0	1497	0	PANX2	22	50616632	Frame_Shift_Del	DEL	TG	TCGA-FD-A3B8-01A-31D-A20D-08	9070762	50616632	687934	72	23025										
BMX	660	broad.mit.edu	37	chrX	15540611	15540611	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	cagtctagcgcaatatgacaGcaactcaaagaaaatctatg	7	9	3	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:15540611G>A	uc004cww.2	+	7	841	c.653G>A	c.(652-654)AGC>AAC	p.S218N	BMX_uc004cwx.3_Missense_Mutation_p.S218N|BMX_uc004cwy.3_Missense_Mutation_p.S218N	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	218					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					CAATATGACAGCAACTCAAAG	0.438													0	0	0	0.004672	0	3	67										A	15540611	G	A	15540611	3	1	76	1	0	0	0	0	1	0	0	0	1473	971	34	2	675	2	BMX	23	15540611	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08		15540611	139729949	73	23026										
TAB3	257397	broad.mit.edu	37	chrX	30872793	30872793	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	gtccttgttgatatggatggGgtggagtagttgaaggacta	16	3	0	2			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:30872793G>C	uc004dcj.2	-	6	1652	c.989C>G	c.(988-990)CCC>CGC	p.P330R	TAB3_uc004dck.2_Missense_Mutation_p.P330R|TAB3_uc010ngl.2_Missense_Mutation_p.P330R	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	330	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						ATATGGATGGGGTGGAGTAGT	0.478													0	0	0	0.014758	0	5	40										C	30872793	G	C	30872793	3	2	76	1	0	0	0	0	1	0	0	0	15494	1232	43	4	1173	4	TAB3	23	30872793	Missense_Mutation	SNP	G	TCGA-FD-A3B8-01A-31D-A20D-08	15332182	30872793	124397767	74	23027										
ZXDB	158586	broad.mit.edu	37	chrX	57619475	57619475	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	tgcagtcgcacgacaaactgCggccctttggctgcccggca	12	15	0	0			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:57619475C>T	uc004dvd.2	+	1	1207	c.994C>T	c.(994-996)CGG>TGG	p.R332W		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	332	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CGACAAACTGCGGCCCTTTGG	0.602													0	0	0	0.004672	0	3	13										T	57619475	C	T	57619475	3	4	76	1	0	0	0	0	1	0	0	0	18248	759	27	2	996	2	ZXDB	23	57619475	Missense_Mutation	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	26746682	57619475	97651085	75	23028										
PGK1	5230	broad.mit.edu	37	chrX	77372877	77372877	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.453333333333333	34	7.49641873835194e-12	3.51053864168618	4.77803535207186	2.36186974789916	0.0306495909036777	0.0866184090756109	24	aagctaggggatgtctatgtCaatgatgcttttggcactgc	12	7	2	1			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:77372877C>T	uc004ecz.3	+	5	658	c.486C>T	c.(484-486)GTC>GTT	p.V162V	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Silent_p.V134V	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	162					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						ATGTCTATGTCAATGATGCTT	0.433													0	0	0	0.021553	0	4	45										T	77372877	C	T	77372877	2	4	76	1	0	0	0	0	0	0	0	1	11790	813	29	1		1	PGK1	23	77372877	Silent	SNP	C	TCGA-FD-A3B8-01A-31D-A20D-08	19753402	77372877	77897683	76	23029										
LRRC47	57470	broad.mit.edu	37	chr1	3697775	3697775	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	accaccagaagggagggcccGtcctttccagcactgggatt	12	13	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:3697775G>A	uc001akx.1	-	7	1657	c.1629C>T	c.(1627-1629)GAC>GAT	p.D543D		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	543					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		GGGAGGGCCCGTCCTTTCCAG	0.572													0	0	0	0.00361	0	43	101										A	3697775	G	A	3697775	2	1	77	1	0	0	0	0	0	0	0	1	9004	1136	40	2		2	LRRC47	1	3697775	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08		3697775	245552846	1	23030										
TNFRSF1B	7133	broad.mit.edu	37	chr1	12251945	12251945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccggctgtgcgcgccgctgcGcaagtgccgcccgggcttcg	16	17	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:12251945G>A	uc001att.2	+	4	511	c.422G>A	c.(421-423)CGC>CAC	p.R141H	TNFRSF1B_uc001atu.2_5'UTR|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	141	TNFR-Cys 3.|Extracellular (Potential).			R -> P (in Ref. 15; AAA63262).	apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GCGCCGCTGCGCAAGTGCCGC	0.687													0	0	0	0.00361	0	69	59										A	12251945	G	A	12251945	3	1	77	1	0	0	0	0	1	0	0	0	16291	1087	38	2	436	2	TNFRSF1B	1	12251945	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	8554170	12251945	236998676	2	23031										
PDPN	10630	broad.mit.edu	37	chr1	13933692	13933692	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cacaggccagccagaagatgAcactgagactacaggtttgg	12	10	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:13933692A>T	uc001avd.2	+	2	369	c.320A>T	c.(319-321)GAC>GTC	p.D107V	PDPN_uc001avc.2_Missense_Mutation_p.D107V|PDPN_uc009vob.2_5'UTR|PDPN_uc009voc.2_5'UTR|PDPN_uc001ave.2_5'UTR|PDPN_uc001avf.2_5'UTR	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	31	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CCAGAAGATGACACTGAGACT	0.517													0	0	0	0.006999	0	34	52										T	13933692	A	T	13933692	3	4	77	1	0	0	0	0	1	0	0	0	11688	275	10	5	326	5	PDPN	1	13933692	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1681747	13933692	235316929	3	23032										
EPHA2	1969	broad.mit.edu	37	chr1	16456035	16456035	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagccactcggacaccgtgcGgaagggcaccccctccgagc	12	18	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:16456035G>T	uc001aya.1	-	16	2856	c.2719C>A	c.(2719-2721)CGC>AGC	p.R907S		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	907	SAM.|Cytoplasmic (Potential).|Negatively regulates interaction with ARHGEF16.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GACACCGTGCGGAAGGGCACC	0.478													1	0	1.66795e-42	0.00361	1.91836e-42	74	59										T	16456035	G	T	16456035	3	4	77	1	0	0	0	0	1	0	0	0	5167	1116	39	4	219	4	EPHA2	1	16456035	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2522343	16456035	232794586	4	23033										
MAP3K6	9064	broad.mit.edu	37	chr1	27683217	27683233	+	Frame_Shift_Del	DEL	GTGAGACCGCCTCCTTC	GTGAGACCGCCTCCTTC	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	actcagctcctctgacctcgGtgagaccgcctccttctcca							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:27683217_27683233delGTGAGACCGCCTCCTTC	uc001bny.1	-	25	3621_3637	c.3372_3388delGAAGGAGGCGGTCTCAC	c.(3370-3390)GAGAAGGAGGCGGTCTCACCGfs	p.E1124fs	MAP3K6_uc009vsw.1_Frame_Shift_Del_p.E1116fs	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1124_1130					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGACCTCGGTGAGACCGCCTCCTTCTCCACCTCTG	0.664																		7	64	---	---								-	27683233	GTGAGACCGCCTCCTTC	-	27683217	7	5	77	1	0	1	0	1	0	0	0	0	9254	1261	44	0	498	0	MAP3K6	1	27683217	Frame_Shift_Del	DEL	GTGAGACCGCCTCCTTC	TCGA-FD-A3N5-01A-11D-A21A-08	11227182	27683217	221567404	5	23034										
WASF2	10163	broad.mit.edu	37	chr1	27745578	27745578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gagctctccaaaaatgtcctCtgcatatttacctggaaaga	7	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:27745578C>T	uc001bof.1	-	3	358	c.142G>A	c.(142-144)GAG>AAG	p.E48K	WASF2_uc010ofl.1_Missense_Mutation_p.E48K	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	48					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		AAAATGTCCTCTGCATATTTA	0.443													0	0	0	0.008291	0	7	35										T	27745578	C	T	27745578	3	4	77	1	0	0	0	0	1	0	0	0	17250	922	32	1	1382	1	WASF2	1	27745578	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	62361	27745578	221505043	6	23035										
STX12	23673	broad.mit.edu	37	chr1	28099877	28099877	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccctcggggccccagctccGggacttcagcagcatcatcc	11	18	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:28099877G>C	uc001bou.3	+	1	184	c.59G>C	c.(58-60)CGG>CCG	p.R20P		NM_177424	NP_803173	Q86Y82	STX12_HUMAN	syntaxin 12	20	Cytoplasmic (Potential).				cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCAGCTCCGGGACTTCAGC	0.657													0	0	0	0.006999	0	37	39										C	28099877	G	C	28099877	3	2	77	1	0	0	0	0	1	0	0	0	15337	1116	39	4	61	4	STX12	1	28099877	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	354299	28099877	221150744	7	23036										
EPB41	2035	broad.mit.edu	37	chr1	29314319	29314319	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aatttggaaccagtcttgatGaagagatcattttaaaggcc	9	6	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:29314319G>A	uc001brm.1	+	1	377	c.370G>A	c.(370-372)GAA>AAA	p.E124K	EPB41_uc001brg.1_5'UTR|EPB41_uc001brh.1_5'UTR|EPB41_uc001bri.1_Missense_Mutation_p.E124K|EPB41_uc001brj.1_5'UTR|EPB41_uc009vtk.1_Missense_Mutation_p.E124K|EPB41_uc001brk.2_Missense_Mutation_p.E124K|EPB41_uc001brl.1_Missense_Mutation_p.E124K|EPB41_uc009vtl.1_5'UTR|EPB41_uc009vtm.1_5'UTR	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	124					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		CAGTCTTGATGAAGAGATCAT	0.423													0	0	0	0.003163	0	13	36										A	29314319	G	A	29314319	3	1	77	1	0	0	0	0	1	0	0	0	5151	1291	45	1	372	1	EPB41	1	29314319	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1214442	29314319	219936302	8	23037										
CLSPN	63967	broad.mit.edu	37	chr1	36235553	36235553	+	Splice_Site	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agcagcggctcccgccgtctCcagcccagcagtgctgttct	11	17	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:36235553C>T	uc001bzi.2	-	1	1	c.-79_splice	c.e1-1		CLSPN_uc009vux.2_Splice_Site	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin						activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCCGCCGTCTCCAGCCCAGCA	0.642													0	0	0	0.004482	0	9	29										T	36235553	C	T	36235553	5	4	77	1	0	0	0	0	0	0	1	0	3560	870	30	1		1	CLSPN	1	36235553	Splice_Site	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	6921234	36235553	213015068	9	23038										
EIF2C1	26523	broad.mit.edu	37	chr1	36367599	36367599	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tacatccaggaatttgggatCaaagtgaaggatgacatgac	11	6	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:36367599C>A	uc001bzl.2	+	10	1404	c.1191C>A	c.(1189-1191)ATC>ATA	p.I397I	EIF2C1_uc001bzk.2_Silent_p.I322I|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	397					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AATTTGGGATCAAAGTGAAGG	0.542													1	0	1.22674e-20	0.00874	1.35988e-20	38	64										A	36367599	C	A	36367599	2	1	77	1	0	0	0	0	0	0	0	1	5005	816	29	3		3	EIF2C1	1	36367599	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	132046	36367599	212883022	10	23039										
KIAA0754	643314	broad.mit.edu	37	chr1	39876847	39876847	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agctgttagatccagaattgCatgttctcataacccccagc	7	12	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:39876847C>G	uc009vvt.1	+	1	1672	c.910C>G	c.(910-912)CAT>GAT	p.H304D	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	168											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCCAGAATTGCATGTTCTCAT	0.522											OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	6	15										G	39876847	C	G	39876847	3	3	77	1	0	0	0	0	1	0	0	0	8192	710	25	4	912	4	KIAA0754	1	39876847	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3509248	39876847	209373774	11	23040										
SLFNL1	200172	broad.mit.edu	37	chr1	41486281	41486281	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggactcctcaccccaggactCcatgaagggctctgacacct	9	16	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:41486281C>T	uc001cgm.1	-	2	272	c.52G>A	c.(52-54)GAG>AAG	p.E18K	SLFNL1_uc009vwf.1_Missense_Mutation_p.E18K|SLFNL1_uc001cgn.1_Missense_Mutation_p.E18K|SLFNL1_uc009vwg.1_Missense_Mutation_p.E18K	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	18							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCCCAGGACTCCATGAAGGGC	0.607													0	0	0	0.00361	0	67	62										T	41486281	C	T	41486281	3	4	77	1	0	0	0	0	1	0	0	0	14738	864	30	1	1187	1	SLFNL1	1	41486281	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1609434	41486281	207764340	12	23041										
TMEM53	79639	broad.mit.edu	37	chr1	45120323	45120323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctgacgtgtgcagatgacaCgaaatccacagaacgcgcca	11	12	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:45120323C>T	uc001cmc.2	-	3	778	c.742G>A	c.(742-744)GTG>ATG	p.V248M	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Missense_Mutation_p.V175M|TMEM53_uc009vxh.1_Missense_Mutation_p.V131M|TMEM53_uc010ola.1_Missense_Mutation_p.V131M	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	248						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					GCAGATGACACGAAATCCACA	0.592													0	0	0	0.00361	0	118	134										T	45120323	C	T	45120323	3	4	77	1	0	0	0	0	1	0	0	0	16176	536	19	2	95	2	TMEM53	1	45120323	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3634042	45120323	204130298	13	23042										
NASP	4678	broad.mit.edu	37	chr1	46073334	46073334	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagtttctggaactgatgtcCaagaagagtgcagagaaaaa	11	6	1	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46073334C>A	uc001coi.1	+	6	853	c.751C>A	c.(751-753)CAA>AAA	p.Q251K	NASP_uc010olq.1_Missense_Mutation_p.Q214K|NASP_uc001coh.1_Missense_Mutation_p.Q253K|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Missense_Mutation_p.Q187K|NASP_uc001cok.1_Missense_Mutation_p.Q134K	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	251	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					AACTGATGTCCAAGAAGAGTG	0.478													1	0	2.56e-06	0.009096	2.64e-06	3	16										A	46073334	C	A	46073334	3	1	77	1	0	0	0	0	1	0	0	0	10172	595	21	4	850	4	NASP	1	46073334	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	953011	46073334	203177287	14	23043										
MAST2	23139	broad.mit.edu	37	chr1	46497147	46497147	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgacctggctgtgcgtagggCccgccaccggctgctctctg	14	15	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46497147C>A	uc001cov.2	+	24	3360	c.3077C>A	c.(3076-3078)GCC>GAC	p.A1026D	MAST2_uc001cow.2_Missense_Mutation_p.A1026D|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1026					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GTGCGTAGGGCCCGCCACCGG	0.627													1	0	1.57351e-24	0.003755	1.75791e-24	32	96										A	46497147	C	A	46497147	3	1	77	1	0	0	0	0	1	0	0	0	9325	739	26	4	3171	4	MAST2	1	46497147	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	423813	46497147	202753474	15	23044										
MAST2	23139	broad.mit.edu	37	chr1	46501315	46501315	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagctgagcatgtggtcctgGaaatcccttattgagggccc	12	10	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46501315G>C	uc001cov.2	+	29	5257	c.4974G>C	c.(4972-4974)TGG>TGC	p.W1658C	MAST2_uc001cow.2_Missense_Mutation_p.W1657C|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1658					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					TGTGGTCCTGGAAATCCCTTA	0.572													0	0	0	0.002299	0	18	49										C	46501315	G	C	46501315	3	2	77	1	0	0	0	0	1	0	0	0	9325	1183	41	1	5088	1	MAST2	1	46501315	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4168	46501315	202749306	16	23045										
UQCRH	7388	broad.mit.edu	37	chr1	46769446	46769446	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	accgtagccagacatgggacTggaggacgagcaaaagatgc	14	9	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46769446T>C	uc001cpp.2	+	1	67	c.8T>C	c.(7-9)CTG>CCG	p.L3P	LRRC41_uc001cpn.2_5'Flank|LRRC41_uc010omb.1_5'Flank|LRRC41_uc001cpo.1_5'Flank|UQCRH_uc001cpq.2_RNA	NM_006004	NP_005995	P07919	QCR6_HUMAN	ubiquinol-cytochrome c reductase hinge protein	3					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c		ubiquinol-cytochrome-c reductase activity				0	Acute lymphoblastic leukemia(166;0.155)					GACATGGGACTGGAGGACGAG	0.552													0	0	0	0.005443	0	20	60										C	46769446	T	C	46769446	3	2	77	1	0	0	0	0	1	0	0	0	17019	1580	55	5	10	5	UQCRH	1	46769446	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	268131	46769446	202481175	17	23046										
ATPAF1	64756	broad.mit.edu	37	chr1	47110887	47110887	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtacctgtccattgtcctacAaaaaactcataaccttccct	3	14	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:47110887A>G	uc001cqh.2	-	7	735	c.630T>C	c.(628-630)TTT>TTC	p.F210F	ATPAF1_uc001cqg.2_Intron|ATPAF1_uc009vyk.2_Silent_p.F59F|ATPAF1_uc010omg.1_Silent_p.F122F|ATPAF1_uc001cqi.2_Intron	NM_022745	NP_073582	Q5TC12	ATPF1_HUMAN	ATP synthase mitochondrial F1 complex assembly	210					protein complex assembly	mitochondrion	protein binding				0	Acute lymphoblastic leukemia(166;0.155)					ATTGTCCTACAAAAAACTCAT	0.398													0	0	0	0.006122	0	15	48										G	47110887	A	G	47110887	2	3	77	1	0	0	0	0	0	0	0	1	1200	127	5	5		5	ATPAF1	1	47110887	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	341441	47110887	202139734	18	23047										
RAB3B	5865	broad.mit.edu	37	chr1	52442691	52442691	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagaggaaggaggtcttgccAacactgctgttgccaatgat	12	8	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:52442691A>C	uc001cth.2	-	2	224	c.99T>G	c.(97-99)GTT>GTG	p.V33V		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	33	GTP.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						AGGTCTTGCCAACACTGCTGT	0.483													0	0	0	0.00361	0	67	39										C	52442691	A	C	52442691	2	2	77	1	0	0	0	0	0	0	0	1	12932	117	5	5		5	RAB3B	1	52442691	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5331804	52442691	196807930	19	23048										
CC2D1B	200014	broad.mit.edu	37	chr1	52821951	52821951	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggatctccagctgtttcttgCggtcctgagcaagcttctca	10	12	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:52821951C>G	uc001ctq.1	-	18	2117	c.1979G>C	c.(1978-1980)CGC>CCC	p.R660P	CC2D1B_uc001ctr.2_Missense_Mutation_p.R200P|CC2D1B_uc001cts.2_Missense_Mutation_p.R345P	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	660										ovary(2)	2						CTGTTTCTTGCGGTCCTGAGC	0.567													0	0	0	0.00874	0	39	126										G	52821951	C	G	52821951	3	3	77	1	0	0	0	0	1	0	0	0	2727	768	27	4	625	4	CC2D1B	1	52821951	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	379260	52821951	196428670	20	23049										
PODN	127435	broad.mit.edu	37	chr1	53542872	53542872	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgacccccaggtctgtgtacCtgcacaacaacaagctggca	9	14	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:53542872C>G	uc001cuv.2	+	6	743	c.736C>G	c.(736-738)CTG>GTG	p.L246V	PODN_uc001cuw.2_Missense_Mutation_p.L227V|PODN_uc010onr.1_Missense_Mutation_p.L227V|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	198	LRR 5.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GTCTGTGTACCTGCACAACAA	0.627													0	0	0	0.00361	0	66	204										G	53542872	C	G	53542872	3	3	77	1	0	0	0	0	1	0	0	0	12178	680	24	4	758	4	PODN	1	53542872	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	720921	53542872	195707749	21	23050										
EFCAB7	84455	broad.mit.edu	37	chr1	64021038	64021038	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tttgagaaaaggtgtttggaTggactggtgaactaggacct	14	4	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:64021038T>C	uc001dbf.2	+	9	1360	c.1066T>C	c.(1066-1068)TGG>CGG	p.W356R		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	356							calcium ion binding				0						GGTGTTTGGATGGACTGGTGA	0.343													0	0	0	0.00361	0	34	22										C	64021038	T	C	64021038	3	2	77	1	0	0	0	0	1	0	0	0	4940	1464	51	5	1096	5	EFCAB7	1	64021038	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	10478166	64021038	185229583	22	23051										
TNNI3K	51086	broad.mit.edu	37	chr1	74835181	74835181	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcgtaattcagtttgtgggtGcttgcttgaatgatcccagc	12	8	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:74835181G>A	uc001dgf.1	+	16	1630	c.1579G>A	c.(1579-1581)GCT>ACT	p.A527T	TNNI3K_uc001dgc.1_Missense_Mutation_p.A628T|TNNI3K_uc001dgd.2_Missense_Mutation_p.A628T|TNNI3K_uc001dge.1_Missense_Mutation_p.A628T	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	527	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						GTTTGTGGGTGCTTGCTTGAA	0.478													0	0	0	0.002096	0	26	61										A	74835181	G	A	74835181	3	1	77	1	0	0	0	0	1	0	0	0	16326	1319	46	2	1996	2	TNNI3K	1	74835181	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	10814143	74835181	174415440	23	23052										
ZZZ3	26009	broad.mit.edu	37	chr1	78050334	78050334	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcaatcgtctgtaatagtctCtgataactacagagacaaag	8	8	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:78050334C>T	uc001dhq.2	-	6	1988	c.1512G>A	c.(1510-1512)CAG>CAA	p.Q504Q	ZZZ3_uc001dhr.2_Silent_p.Q10Q|ZZZ3_uc009wbz.1_3'UTR|ZZZ3_uc001dhp.2_Silent_p.Q504Q	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						GTAATAGTCTCTGATAACTAC	0.373													0	0	0	0.00308	0	7	17										T	78050334	C	T	78050334	2	4	77	1	0	0	0	0	0	0	0	1	18253	912	32	1		1	ZZZ3	1	78050334	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3215153	78050334	171200287	24	23053										
COL24A1	255631	broad.mit.edu	37	chr1	86590911	86590911	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	attgtcagacatgtttaggaGagagctaaatttctctttgg	10	5	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:86590911G>A	uc001dlj.2	-	3	1150	c.1108C>T	c.(1108-1110)CTC>TTC	p.L370F	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.L370F	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	370					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATGTTTAGGAGAGAGCTAAAT	0.378													0	0	0	0.009535	0	21	19										A	86590911	G	A	86590911	3	1	77	1	0	0	0	0	1	0	0	0	3683	942	33	1	4268	1	COL24A1	1	86590911	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	8540577	86590911	162659710	25	23054										
SLC30A7	148867	broad.mit.edu	37	chr1	101362198	101362198	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aacctctctttcgcttttgtGgaactactctacggcatctg	7	12	3	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:101362198G>A	uc001dtn.2	+	2	340	c.153G>A	c.(151-153)GTG>GTA	p.V51V	EXTL2_uc001dtk.1_5'Flank|EXTL2_uc001dtl.1_5'Flank|EXTL2_uc010ouk.1_5'Flank|EXTL2_uc001dtm.1_5'Flank|SLC30A7_uc001dto.2_Silent_p.V51V	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	51	Helical; (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		TCGCTTTTGTGGAACTACTCT	0.502													0	0	0	0.00308	0	7	19										A	101362198	G	A	101362198	2	1	77	1	0	0	0	0	0	0	0	1	14560	1335	47	2		2	SLC30A7	1	101362198	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	14771287	101362198	147888423	26	23055										
KIAA1324	57535	broad.mit.edu	37	chr1	109731742	109731742	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgtgggatttgaatacaaatGgtggaacacgctgcccacaa	11	8	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:109731742G>A	uc001dwq.2	+	11	1410	c.1274G>A	c.(1273-1275)TGG>TAG	p.W425*	KIAA1324_uc009wex.1_Nonsense_Mutation_p.W375*|KIAA1324_uc009wey.2_Nonsense_Mutation_p.W338*|KIAA1324_uc010ovg.1_Nonsense_Mutation_p.W323*|KIAA1324_uc001dwr.2_Nonsense_Mutation_p.W75*	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	425	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GAATACAAATGGTGGAACACG	0.527													0	0	0	0.003271	0	30	30										A	109731742	G	A	109731742	4	1	77	1	0	0	0	0	0	1	0	0	8223	1357	47	2	1312	2	KIAA1324	1	109731742	Nonsense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	8369544	109731742	139518879	27	23056										
PTPN22	26191	broad.mit.edu	37	chr1	114372323	114372323	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atgtttctatagattgggccTgcataccttaaaaaaaaaaa	6	6	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:114372323T>G	uc001eds.2	-	18	2271	c.2141A>C	c.(2140-2142)CAG>CCG	p.Q714P	PTPN22_uc009wgq.2_Missense_Mutation_p.Q659P|PTPN22_uc010owo.1_Missense_Mutation_p.Q470P|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.Q714P|PTPN22_uc009wgs.2_Missense_Mutation_p.Q587P	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	714					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGATTGGGCCTGCATACCTTA	0.338													0	0	0	0.004672	0	3	15										G	114372323	T	G	114372323	3	3	77	1	0	0	0	0	1	0	0	0	12787	1580	55	5	298	5	PTPN22	1	114372323	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	4640581	114372323	134878298	28	23057										
AP4B1	10717	broad.mit.edu	37	chr1	114442966	114442966	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cttcctcactgcggggttggTagcgtagcagaaagttcaat	12	9	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:114442966T>C	uc001eeb.2	-	5	817	c.674A>G	c.(673-675)TAC>TGC	p.Y225C	uc001edv.1_RNA|AP4B1_uc001eec.2_Missense_Mutation_p.Y57C|AP4B1_uc001eed.2_Missense_Mutation_p.Y225C|AP4B1_uc010owp.1_Missense_Mutation_p.Y126C|AP4B1_uc001eea.1_Missense_Mutation_p.Y19C|AP4B1_uc010owq.1_Missense_Mutation_p.Y132C	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	225					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGGGGTTGGTAGCGTAGCAG	0.423													0	0	0	0.00632	0	21	29										C	114442966	T	C	114442966	3	2	77	1	0	0	0	0	1	0	0	0	751	1638	57	5	1569	5	AP4B1	1	114442966	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	70643	114442966	134807655	29	23058										
HIPK1	204851	broad.mit.edu	37	chr1	114512680	114512680	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccttattccactgataccctGagtgctctccgaggcaatag	8	13	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:114512680G>A	uc001eem.2	+	14	3035	c.2874G>A	c.(2872-2874)CTG>CTA	p.L958L	HIPK1_uc001eel.2_Silent_p.L958L|HIPK1_uc001een.2_Silent_p.L958L|HIPK1_uc001eeo.2_Silent_p.L584L|HIPK1_uc001eep.2_Silent_p.L564L|HIPK1_uc001eeq.2_Silent_p.L250L	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	958	Required for localization to nuclear speckles (By similarity).|Interaction with TP53.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGATACCCTGAGTGCTCTCC	0.507													0	0	0	0.00361	0	49	103										A	114512680	G	A	114512680	2	1	77	1	0	0	0	0	0	0	0	1	7116	1277	45	1		1	HIPK1	1	114512680	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	69714	114512680	134737941	30	23059										
ZNF697	90874	broad.mit.edu	37	chr1	120166097	120166097	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcttgccgcagtcggcgcacAggttgggccgctcgcccgtg	15	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:120166097A>T	uc001ehy.1	-	3	983	c.869T>A	c.(868-870)CTG>CAG	p.L290Q		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	290	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		GTCGGCGCACAGGTTGGGCCG	0.687													0	0	0	0.004656	0	21	17										T	120166097	A	T	120166097	3	4	77	1	0	0	0	0	1	0	0	0	18097	188	7	5	772	5	ZNF697	1	120166097	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5653417	120166097	129084524	31	23060										
NOTCH2	4853	broad.mit.edu	37	chr1	120529583	120529583	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	attctccacactgtacatacCtgtccattgtgggggacagc	9	12	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:120529583C>T	uc001eik.2	-	5	1130	c.874G>A	c.(874-876)GGA>AGA	p.G292R	NOTCH2_uc001eil.2_Missense_Mutation_p.G292R|NOTCH2_uc001eim.3_Missense_Mutation_p.G209R	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	292	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGTACATACCTGTCCATTGT	0.458			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.00361	0	37	44										T	120529583	C	T	120529583	3	4	77	1	0	0	0	0	1	0	0	0	10548	695	24	2	6661	2	NOTCH2	1	120529583	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	363486	120529583	128721038	32	23061										
RPRD2	23248	broad.mit.edu	37	chr1	150444196	150444196	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtaagagggaatgaacctggGtctgaccggtcaccatcacc	12	11	3	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:150444196G>T	uc009wlr.2	+	11	2973	c.2772G>T	c.(2770-2772)GGG>GGT	p.G924G	RPRD2_uc010pcc.1_Silent_p.G898G|RPRD2_uc001eup.3_Silent_p.G898G	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	924	Ser-rich.						protein binding			ovary(1)	1						ATGAACCTGGGTCTGACCGGT	0.507													1	0	1.28101e-76	0.00361	1.49742e-76	127	119										T	150444196	G	T	150444196	2	4	77	1	0	0	0	0	0	0	0	1	13617	1248	44	4		4	RPRD2	1	150444196	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	29914613	150444196	98806425	33	23062										
FLG2	388698	broad.mit.edu	37	chr1	152328005	152328005	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tccaaagccagaggattgtcCtgagccagacccatgttgtc	10	12	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:152328005C>T	uc001ezw.3	-	3	2330	c.2257G>A	c.(2257-2259)GGA>AGA	p.G753R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	753	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGATTGTCCTGAGCCAGAC	0.512													0	0	0	0.00361	0	148	236										T	152328005	C	T	152328005	3	4	77	1	0	0	0	0	1	0	0	0	5923	690	24	2	4922	2	FLG2	1	152328005	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1883809	152328005	96922616	34	23063										
GON4L	54856	broad.mit.edu	37	chr1	155796703	155796703	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agtcctgagtggcttttcttGaggagaggcacaaacatctg	12	8	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:155796703G>C	uc001flz.2	-	3	719	c.622C>G	c.(622-624)CAA>GAA	p.Q208E	GON4L_uc001fly.1_Missense_Mutation_p.Q208E|GON4L_uc009wrh.1_Missense_Mutation_p.Q208E|GON4L_uc001fma.1_Missense_Mutation_p.Q208E|GON4L_uc001fmc.2_Missense_Mutation_p.Q208E|GON4L_uc001fmd.3_Missense_Mutation_p.Q208E|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.Q36E	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	208					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGCTTTTCTTGAGGAGAGGCA	0.468													0	0	0	0.006122	0	14	49										C	155796703	G	C	155796703	3	2	77	1	0	0	0	0	1	0	0	0	6572	1299	45	1	6337	1	GON4L	1	155796703	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3468698	155796703	93453918	35	23064										
OR10Z1	128368	broad.mit.edu	37	chr1	158576875	158576875	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctccttcttcttcatcaccaTctcctacgcctacatcttgg	3	17	6	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:158576875T>C	uc010pio.1	+	1	647	c.647T>C	c.(646-648)ATC>ACC	p.I216T		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TTCATCACCATCTCCTACGCC	0.532													0	0	0	0.009535	0	30	34										C	158576875	T	C	158576875	3	2	77	1	0	0	0	0	1	0	0	0	10923	1435	50	5	649	5	OR10Z1	1	158576875	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2780172	158576875	90673746	36	23065										
ADCY10	55811	broad.mit.edu	37	chr1	167814903	167814903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atagggaatgaagtccctgcCtcggcagtggtcacatctgt	12	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:167814903C>T	uc001ger.2	-	21	3203	c.2905G>A	c.(2905-2907)GGC>AGC	p.G969S	ADCY10_uc009wvk.2_Missense_Mutation_p.G877S|ADCY10_uc010plj.1_Missense_Mutation_p.G816S|ADCY10_uc009wvl.2_Missense_Mutation_p.G968S	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	969					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AAGTCCCTGCCTCGGCAGTGG	0.463													0	0	0	0.007413	0	15	36										T	167814903	C	T	167814903	3	4	77	1	0	0	0	0	1	0	0	0	293	681	24	2	1979	2	ADCY10	1	167814903	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	9238028	167814903	81435718	37	23066										
RFWD2	64326	broad.mit.edu	37	chr1	176133011	176133011	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcaaatctttgcttctgtttAagaatgagttcattcactga	6	7	5	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:176133011A>G	uc001gku.1	-	4	838	c.582T>C	c.(580-582)CTT>CTC	p.L194L	RFWD2_uc001gkv.1_Silent_p.L194L|RFWD2_uc001gkw.1_Intron|RFWD2_uc009wwv.2_5'Flank|RFWD2_uc001gkt.1_Silent_p.L53L	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	194					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCTTCTGTTTAAGAATGAGTT	0.289													0	0	0	0.004672	0	2	7										G	176133011	A	G	176133011	2	3	77	1	0	0	0	0	0	0	0	1	13260	349	13	5		5	RFWD2	1	176133011	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	8318108	176133011	73117610	38	23067										
PRG4	10216	broad.mit.edu	37	chr1	186280667	186280667	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggactaactggacaaatagtGgcagcgctttcaacagctaa	10	9	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:186280667G>A	uc001gru.3	+	10	3783	c.3732G>A	c.(3730-3732)GTG>GTA	p.V1244V	PRG4_uc001grt.3_Silent_p.V1203V|PRG4_uc009wyl.2_Silent_p.V1151V|PRG4_uc009wym.2_Silent_p.V1110V|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1244					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GACAAATAGTGGCAGCGCTTT	0.363													0	0	0	0.00308	0	7	16										A	186280667	G	A	186280667	2	1	77	1	0	0	0	0	0	0	0	1	12481	1335	47	2		2	PRG4	1	186280667	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	10147656	186280667	62969954	39	23068										
CRB1	23418	broad.mit.edu	37	chr1	197390711	197390711	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgacccttaccttaatcgacGactcctgtaaggagaaatgc	8	11	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:197390711G>C	uc001gtz.2	+	6	1888	c.1753G>C	c.(1753-1755)GAC>CAC	p.D585H	CRB1_uc010poz.1_Missense_Mutation_p.D516H|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Missense_Mutation_p.D473H|CRB1_uc010ppb.1_Missense_Mutation_p.D585H|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.D66H|CRB1_uc001gub.1_Missense_Mutation_p.D234H	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	585	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTTAATCGACGACTCCTGTAA	0.453													0	0	0	0.008871	0	20	24										C	197390711	G	C	197390711	3	2	77	1	0	0	0	0	1	0	0	0	3848	1058	37	1	1775	1	CRB1	1	197390711	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	11110044	197390711	51859910	40	23069										
SYT2	127833	broad.mit.edu	37	chr1	202569525	202569525	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atcttcttgaggttcttagcCtccaggatgcagacagtgag	11	9	3	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:202569525C>T	uc001gye.2	-	7	1072	c.879G>A	c.(877-879)GAG>GAA	p.E293E	SYT2_uc010pqb.1_Silent_p.E293E|SYT2_uc009xaf.2_Silent_p.E123E	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	293	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	GGTTCTTAGCCTCCAGGATGC	0.617											OREG0014101	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	56	55										T	202569525	C	T	202569525	2	4	77	1	0	0	0	0	0	0	0	1	15471	680	24	2		2	SYT2	1	202569525	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5178814	202569525	46681096	41	23070										
CYB5R1	51706	broad.mit.edu	37	chr1	202935955	202935955	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggccggcgggacctccgaacCaagtaggagcccacagccag	14	15	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:202935955C>T	uc001gyt.2	-	2	158	c.87G>A	c.(85-87)TTG>TTA	p.L29L	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	29					sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			ACCTCCGAACCAAGTAGGAGC	0.642													0	0	0	0.004482	0	9	37										T	202935955	C	T	202935955	2	4	77	1	0	0	0	0	0	0	0	1	4126	593	21	2		2	CYB5R1	1	202935955	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	366430	202935955	46314666	42	23071										
REN	5972	broad.mit.edu	37	chr1	204124152	204124152	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggcagagggcctcagcgggCcaaggcgaagccaatgcggt	17	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:204124152C>T	uc001haq.2	-	10	1257	c.1213G>A	c.(1213-1215)GCC>ACC	p.A405T	ETNK2_uc001hao.3_5'Flank|ETNK2_uc001han.3_5'Flank|ETNK2_uc010pqs.1_5'Flank|ETNK2_uc010pqt.1_5'Flank	NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	405					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CCTCAGCGGGCCAAGGCGAAG	0.647													0	0	0	0.00333	0	18	66										T	204124152	C	T	204124152	3	4	77	1	0	0	0	0	1	0	0	0	13224	739	26	2	11	2	REN	1	204124152	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1188197	204124152	45126469	43	23072										
LRRN2	10446	broad.mit.edu	37	chr1	204587882	204587882	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagtggtccgtcatctcccgGaagggcacctcacggaccgg	13	15	3	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:204587882G>A	uc001hbe.1	-	3	1627	c.1239C>T	c.(1237-1239)TTC>TTT	p.F413F	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Silent_p.F413F|LRRN2_uc009xbf.1_Silent_p.F413F|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	413	Extracellular (Potential).|LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TCATCTCCCGGAAGGGCACCT	0.662													0	0	0	0.010504	0	20	67										A	204587882	G	A	204587882	2	1	77	1	0	0	0	0	0	0	0	1	9035	1165	41	1		1	LRRN2	1	204587882	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	463730	204587882	44662739	44	23073										
CR1	1378	broad.mit.edu	37	chr1	207679368	207679369	+	Missense_Mutation	DNP	CC	CC	GA													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccctggttattccggaagaCcgttttctatcatctgccta							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:207679368_207679369CC>GA	uc001hfy.2	+	2	381_382	c.241_242CC>GA	c.(241-243)CCG>GAG	p.P81E	CR1_uc009xcl.1_Missense_Mutation_p.P81E|CR1_uc001hfx.2_Missense_Mutation_p.P81E|CR1_uc010psg.1_Missense_Mutation_p.P81E|CR1_uc009xcj.1_Missense_Mutation_p.P81E|CR1_uc009xck.1_Missense_Mutation_p.P81E	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	81	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTCCGGAAGACCGTTTTCTATC	0.47													0	0	0	0.004672	0	8	44										GA	207679369	CC	GA	207679368	3	3	77	1	0	0	0	0	1	0	0	0	3840	507	18	4	247	4	CR1	1	207679368	Missense_Mutation	DNP	CC	TCGA-FD-A3N5-01A-11D-A21A-08	3091486	207679368	41571253	45	23074										
CD46	4179	broad.mit.edu	37	chr1	207930506	207930506	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cacccatactatttgtgatcGgaatcatacatggctacctg	7	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:207930506G>A	uc001hgc.2	+	2	401	c.245G>A	c.(244-246)CGG>CAG	p.R82Q	CD46_uc001hgd.2_Missense_Mutation_p.R82Q|CD46_uc001hge.2_Missense_Mutation_p.R82Q|CD46_uc001hgf.2_Missense_Mutation_p.R82Q|CD46_uc001hgg.2_Missense_Mutation_p.R82Q|CD46_uc001hgh.2_Missense_Mutation_p.R82Q|CD46_uc001hgi.2_Missense_Mutation_p.R82Q|CD46_uc001hgj.2_Missense_Mutation_p.R82Q|CD46_uc001hgk.2_Missense_Mutation_p.R82Q|CD46_uc001hgl.2_Missense_Mutation_p.R82Q|CD46_uc001hgm.2_Missense_Mutation_p.R82Q|CD46_uc001hgn.2_Missense_Mutation_p.R82Q|CD46_uc001hgo.2_Missense_Mutation_p.R82Q|CD46_uc001hgp.2_Missense_Mutation_p.R82Q	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	82	Extracellular (Potential).|Sushi 1.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4						ATTTGTGATCGGAATCATACA	0.368													0	0	0	0.006999	0	31	29										A	207930506	G	A	207930506	3	1	77	1	0	0	0	0	1	0	0	0	3018	1116	39	2	251	2	CD46	1	207930506	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	251138	207930506	41320115	46	23075										
FLVCR1	28982	broad.mit.edu	37	chr1	213032442	213032442	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgctcggtggcccaggtgttCatcctgggcttgccctcccg	13	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:213032442C>T	uc001hjt.2	+	1	846	c.648C>T	c.(646-648)TTC>TTT	p.F216F	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	216	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		CCCAGGTGTTCATCCTGGGCT	0.607													0	0	0	0.00361	0	46	67										T	213032442	C	T	213032442	2	4	77	1	0	0	0	0	0	0	0	1	5945	825	29	1		1	FLVCR1	1	213032442	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5101936	213032442	36218179	47	23076										
CDC42BPA	8476	broad.mit.edu	37	chr1	227259910	227259910	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	caaacacacactcccataccCttttcagatctaagctcttc	2	16	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:227259910C>T	uc001hqr.2	-	20	3769	c.2826G>A	c.(2824-2826)AAG>AAA	p.K942K	CDC42BPA_uc001hqq.2_Silent_p.K206K|CDC42BPA_uc001hqs.2_Silent_p.K861K|CDC42BPA_uc009xes.2_Silent_p.K942K|CDC42BPA_uc010pvs.1_Silent_p.K942K|CDC42BPA_uc001hqp.2_Silent_p.K98K|CDC42BPA_uc001hqu.1_Silent_p.K98K	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	942	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTCCCATACCCTTTTCAGATC	0.348													0	0	0	0.000978	0	8	18										T	227259910	C	T	227259910	2	4	77	1	0	0	0	0	0	0	0	1	3072	695	24	2		2	CDC42BPA	1	227259910	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	14227468	227259910	21990711	48	23077										
KIAA1804	84451	broad.mit.edu	37	chr1	233512183	233512183	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttttctcttgtaggataagaCctctctccgatggcaacagt	8	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:233512183C>A	uc001hvt.3	+	8	2095	c.1834C>A	c.(1834-1836)CCT>ACT	p.P612T	KIAA1804_uc001hvu.3_Missense_Mutation_p.P58T	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	612					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				TAGGATAAGACCTCTCTCCGA	0.378													1	0	0.000602214	0.000602	0.000615119	3	17										A	233512183	C	A	233512183	3	1	77	1	0	0	0	0	1	0	0	0	8259	507	18	4	1864	4	KIAA1804	1	233512183	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	6252273	233512183	15738438	49	23078										
FH	2271	broad.mit.edu	37	chr1	241680601	241680601	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggtatcatattctatccggaAggaattttggcttgcctaaa	9	7	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:241680601A>T	uc001hyx.2	-	2	180	c.148T>A	c.(148-150)TTC>ATC	p.F50I		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	50					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		TCTATCCGGAAGGAATTTTGG	0.383			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				0	0	0	0.004672	0	3	16										T	241680601	A	T	241680601	3	4	77	1	0	0	0	0	1	0	0	0	5875	72	3	5	1420	5	FH	1	241680601	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	8168418	241680601	7570020	50	23079										
ACP1	52	broad.mit.edu	37	chr2	275176	275176	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgccacatttgattatataCtatgtatggatgaaagcaat	7	5	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:275176C>T	uc002qwg.2	+	4	364	c.268C>T	c.(268-270)CTA>TTA	p.L90L	ACP1_uc002qwh.2_RNA|ACP1_uc002qwf.2_Silent_p.L90L	NM_007099	NP_009030	P24666	PPAC_HUMAN	acid phosphatase 1, soluble isoform b	90						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			skin(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		TGATTATATACTATGTATGGA	0.343													0	0	0	0.009096	0	4	19										T	275176	C	T	275176	2	4	77	1	0	0	0	0	0	0	0	1	162	564	20	2		2	ACP1	2	275176	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		275176	242924197	51	23080										
RPS7	6201	broad.mit.edu	37	chr2	3623453	3623453	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggacctcaaggctcagctcaGggagctgaatattacggcag	13	10	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:3623453G>A	uc002qxw.2	+	3	228	c.122G>A	c.(121-123)AGG>AAG	p.R41K	RPS7_uc002qxx.2_Missense_Mutation_p.R41K|RPS7_uc002qxy.2_5'Flank	NM_001011	NP_001002	P62081	RS7_HUMAN	ribosomal protein S7	41					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		GCTCAGCTCAGGGAGCTGAAT	0.637													0	0	0	0.006214	0	7	17										A	3623453	G	A	3623453	3	1	77	1	0	0	0	0	1	0	0	0	13660	1000	35	2	128	2	RPS7	2	3623453	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3348277	3623453	239575920	52	23081										
GREB1	9687	broad.mit.edu	37	chr2	11758611	11758611	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cgccccagcccgactgtagcCtcaggaccggccagaggagc	13	17	1	1	rs71446422		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:11758611C>T	uc002rbk.1	+	22	3910	c.3610C>T	c.(3610-3612)CTC>TTC	p.L1204F	GREB1_uc002rbp.1_Missense_Mutation_p.L202F	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1204	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CGACTGTAGCCTCAGGACCGG	0.701													0	0	0	0.001882	0	20	19										T	11758611	C	T	11758611	3	4	77	1	0	0	0	0	1	0	0	0	6760	681	24	2	3800	2	GREB1	2	11758611	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	8135158	11758611	231440762	53	23082										
FAM84A	151354	broad.mit.edu	37	chr2	14774804	14774804	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggcgggaggggaggtgccggCaggcacgcagcccccgcagc	20	14	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:14774804C>T	uc002rbz.1	+	2	943	c.701C>T	c.(700-702)GCA>GTA	p.A234V	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	234										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			GAGGTGCCGGCAGGCACGCAG	0.642													0	0	0	0.001855	0	11	5										T	14774804	C	T	14774804	3	4	77	1	0	0	0	0	1	0	0	0	5641	710	25	2	703	2	FAM84A	2	14774804	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3016193	14774804	228424569	54	23083										
FBXO11	80204	broad.mit.edu	37	chr2	48061799	48061799	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atgaacaaagataagtccatCaaaatgagcctcttgtaccc	6	10	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:48061799C>T	uc010fbl.2	-	7	715	c.601G>A	c.(601-603)GAT>AAT	p.D201N	FBXO11_uc002rwe.2_Missense_Mutation_p.D201N|FBXO11_uc002rwf.2_Missense_Mutation_p.D201N|FBXO11_uc002rwg.1_Missense_Mutation_p.D201N|FBXO11_uc010fbk.2_5'Flank	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	285					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATAAGTCCATCAAAATGAGCC	0.328													0	0	0	0.008291	0	7	14										T	48061799	C	T	48061799	3	4	77	1	0	0	0	0	1	0	0	0	5727	826	29	1	2088	1	FBXO11	2	48061799	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	33286995	48061799	195137574	55	23084										
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48809237	48809237	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttcttgactaccattttcatAagtgtgtgaatgtacaagaa	7	6	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:48809237A>G	uc010yol.1	+	1	1512	c.1465A>G	c.(1465-1467)AAG>GAG	p.K489E	STON1_uc002rwo.3_Missense_Mutation_p.K489E|STON1_uc010fbm.2_Missense_Mutation_p.K489E|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.K489E|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.K489E	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	489					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCATTTTCATAAGTGTGTGAA	0.378													0	0	0	0.004007	0	17	14										G	48809237	A	G	48809237	3	3	77	1	0	0	0	0	1	0	0	0	15316	363	13	5	1467	5	STON1-GTF2A1L	2	48809237	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	747438	48809237	194390136	56	23085										
GPR75	10936	broad.mit.edu	37	chr2	54080390	54080390	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaatccaaaagagtttactgGctgtaagttacatgggctgc	10	7	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:54080390G>T	uc002rxo.3	-	2	1775	c.1504C>A	c.(1504-1506)CCA>ACA	p.P502T	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	502	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GAGTTTACTGGCTGTAAGTTA	0.458													1	0	2.61193e-14	0.009535	2.84396e-14	29	93										T	54080390	G	T	54080390	3	4	77	1	0	0	0	0	1	0	0	0	6708	1203	42	4	122	4	GPR75	2	54080390	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5271153	54080390	189118983	57	23086										
SLC1A4	6509	broad.mit.edu	37	chr2	65248205	65248205	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctgaggaggagacatcgccCctggtgacacaccagaaccc	11	14	1	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:65248205C>T	uc010yqa.1	+	8	1846	c.1524C>T	c.(1522-1524)CCC>CCT	p.P508P	SLC1A4_uc010ypy.1_Silent_p.P288P|SLC1A4_uc010ypz.1_Silent_p.P210P|SLC1A4_uc010fcv.2_3'UTR|SLC1A4_uc002sdh.2_Silent_p.P288P	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	508					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	AGACATCGCCCCTGGTGACAC	0.587													0	0	0	0.00333	0	21	105										T	65248205	C	T	65248205	2	4	77	1	0	0	0	0	0	0	0	1	14434	610	22	2		2	SLC1A4	2	65248205	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	11167815	65248205	177951168	58	23087										
LOXL3	84695	broad.mit.edu	37	chr2	74762468	74762468	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cgggtccctgtcctcttgcaGgtgatgtgggtgccatgatg	15	10	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:74762468G>C	uc002smp.1	-	9	1602	c.1530C>G	c.(1528-1530)ACC>ACG	p.T510T	LOXL3_uc002smo.1_Silent_p.T149T|LOXL3_uc010ffm.1_Silent_p.T454T|LOXL3_uc002smq.1_Silent_p.T365T|LOXL3_uc010ffn.1_Silent_p.T365T	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	510	SRCR 4.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						TCCTCTTGCAGGTGATGTGGG	0.582													0	0	0	0.00874	0	38	38										C	74762468	G	C	74762468	2	2	77	1	0	0	0	0	0	0	0	1	8901	987	35	4		4	LOXL3	2	74762468	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	9514263	74762468	168436905	59	23088										
RNF181	51255	broad.mit.edu	37	chr2	85823723	85823723	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctgcctccaccagctgccaaGactgtggttgagaacctccc	9	16	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:85823723G>T	uc002spv.1	+	2	218	c.168G>T	c.(166-168)AAG>AAT	p.K56N		NM_016494	NP_057578	Q9P0P0	RN181_HUMAN	ring finger protein 181	56							ligase activity|zinc ion binding				0						CAGCTGCCAAGACTGTGGTTG	0.537													1	0	2.98393e-07	0.00278	3.09953e-07	20	28										T	85823723	G	T	85823723	3	4	77	1	0	0	0	0	1	0	0	0	13465	933	33	3	174	3	RNF181	2	85823723	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	11061255	85823723	157375650	60	23089										
AFF3	3899	broad.mit.edu	37	chr2	100343579	100343579	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtctggactctctggctctgCatcacctttctcttaaaaag	7	12	5	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:100343579C>T	uc002tag.2	-	10	1287	c.1051G>A	c.(1051-1053)GCA>ACA	p.A351T	AFF3_uc002taf.2_Missense_Mutation_p.A376T|AFF3_uc010fiq.1_Missense_Mutation_p.A351T|AFF3_uc010yvr.1_Missense_Mutation_p.A505T|AFF3_uc002tah.1_Missense_Mutation_p.A376T|AFF3_uc010fir.1_Missense_Mutation_p.A428T	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	351					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TCTGGCTCTGCATCACCTTTC	0.353													0	0	0	0.000978	0	10	11										T	100343579	C	T	100343579	3	4	77	1	0	0	0	0	1	0	0	0	358	710	25	2	2689	2	AFF3	2	100343579	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	14519856	100343579	142855794	61	23090										
IL18RAP	8807	broad.mit.edu	37	chr2	103068609	103068609	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gactcagtagaacagaaaccActgggaggagctcccagcct	11	12	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:103068609A>G	uc002tbx.2	+	12	2252	c.1768A>G	c.(1768-1770)ACT>GCT	p.T590A	IL18RAP_uc010fiz.2_Missense_Mutation_p.T448A	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	590	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AACAGAAACCACTGGGAGGAG	0.512													0	0	0	0.00245	0	11	33										G	103068609	A	G	103068609	3	3	77	1	0	0	0	0	1	0	0	0	7648	159	6	5	1806	5	IL18RAP	2	103068609	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	2725030	103068609	140130764	62	23091										
RGPD3	653489	broad.mit.edu	37	chr2	107073498	107073498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cacccagtattctgctcttcCatcagtaacatcatttttac	3	13	4	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:107073498C>T	uc010ywi.1	-	4	391	c.334G>A	c.(334-336)GGA>AGA	p.G112R		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	112					intracellular transport		binding			ovary(1)	1						TCTGCTCTTCCATCAGTAACA	0.343													0	0	0	0.00333	0	19	29										T	107073498	C	T	107073498	3	4	77	1	0	0	0	0	1	0	0	0	13287	603	21	2	5022	2	RGPD3	2	107073498	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	4004889	107073498	136125875	63	23092										
NCKAP5	344148	broad.mit.edu	37	chr2	133540952	133540952	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgagtcccactggaaggcgAgttttcagtcctttctcatg	10	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:133540952A>G	uc002ttp.2	-	14	3806	c.3432T>C	c.(3430-3432)ACT>ACC	p.T1144T	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1144							protein binding				0						CTGGAAGGCGAGTTTTCAGTC	0.483													0	0	0	0.003163	0	13	49										G	133540952	A	G	133540952	2	3	77	1	0	0	0	0	0	0	0	1	10223	291	11	5		5	NCKAP5	2	133540952	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	26467454	133540952	109658421	64	23093										
R3HDM1	23518	broad.mit.edu	37	chr2	136409597	136409597	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gatatattcagcagccatcaCcacaggtatattgcttttta	6	9	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:136409597C>T	uc002tuo.2	+	17	2288	c.1918C>T	c.(1918-1920)CCA>TCA	p.P640S	R3HDM1_uc010fni.2_Missense_Mutation_p.P639S|R3HDM1_uc002tup.2_Missense_Mutation_p.P585S|R3HDM1_uc010zbh.1_Missense_Mutation_p.P388S	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	640							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		GCAGCCATCACCACAGGTATA	0.423													0	0	0	0.005524	0	34	33										T	136409597	C	T	136409597	3	4	77	1	0	0	0	0	1	0	0	0	12887	507	18	2	1976	2	R3HDM1	2	136409597	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2868645	136409597	106789776	65	23094										
ARL6IP6	151188	broad.mit.edu	37	chr2	153575447	153575447	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agcagagcccagcctcggcgGtggccggtccaggtcctctc	14	16	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:153575447G>A	uc002tyn.2	+	1	1025	c.309G>A	c.(307-309)CGG>CGA	p.R103R	ARL6IP6_uc002tym.2_Intron|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_5'Flank|PRPF40A_uc010zcd.1_5'Flank|PRPF40A_uc002tyi.2_5'Flank|PRPF40A_uc002tyj.2_5'Flank|PRPF40A_uc002tyl.1_5'Flank	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	103						integral to membrane					0						AGCCTCGGCGGTGGCCGGTCC	0.632													0	0	0	0.002445	0	25	35										A	153575447	G	A	153575447	2	1	77	1	0	0	0	0	0	0	0	1	945	1248	44	2		2	ARL6IP6	2	153575447	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	17165850	153575447	89623926	66	23095										
PKP4	8502	broad.mit.edu	37	chr2	159517954	159517954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtgtgaacacatccgattacGacagcaaggtcagtgccggc	12	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:159517954G>A	uc002tzv.2	+	13	2463	c.2203G>A	c.(2203-2205)GAC>AAC	p.D735N	PKP4_uc002tzt.1_Missense_Mutation_p.D587N|PKP4_uc002tzu.2_Missense_Mutation_p.D735N|PKP4_uc002tzw.2_Missense_Mutation_p.D735N|PKP4_uc002tzx.2_Missense_Mutation_p.D392N|PKP4_uc002tzy.1_Missense_Mutation_p.D393N|PKP4_uc002uaa.2_Missense_Mutation_p.D587N|uc002uab.1_RNA|PKP4_uc002uac.2_5'Flank	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	735	ARM 6.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						ATCCGATTACGACAGCAAGGT	0.572										HNSCC(62;0.18)			0	0	0	0.004878	0	28	140										A	159517954	G	A	159517954	3	1	77	1	0	0	0	0	1	0	0	0	11987	1058	37	1	2249	1	PKP4	2	159517954	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5942507	159517954	83681419	67	23096										
PLA2R1	22925	broad.mit.edu	37	chr2	160876633	160876633	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttacagactgctctgctgagAcacacagctggcttctattt	8	11	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:160876633A>G	uc002ube.1	-	8	1643	c.1436T>C	c.(1435-1437)GTC>GCC	p.V479A	PLA2R1_uc010zcp.1_Missense_Mutation_p.V479A|PLA2R1_uc002ubf.2_Missense_Mutation_p.V479A	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	479	Extracellular (Potential).|C-type lectin 2.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CTCTGCTGAGACACACAGCTG	0.264													0	0	0	0.00245	0	12	20										G	160876633	A	G	160876633	3	3	77	1	0	0	0	0	1	0	0	0	12010	275	10	5	3055	5	PLA2R1	2	160876633	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1358679	160876633	82322740	68	23097										
SCN2A	6326	broad.mit.edu	37	chr2	166231239	166231239	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccattccatctatcatgaaTgtacttctggtttgtctgat	7	9	4	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:166231239T>G	uc002udc.2	+	22	4307	c.4017T>G	c.(4015-4017)AAT>AAG	p.N1339K	SCN2A_uc002udd.2_Missense_Mutation_p.N1339K|SCN2A_uc002ude.2_Missense_Mutation_p.N1339K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1339	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CTATCATGAATGTACTTCTGG	0.363													0	0	0	0.004007	0	13	18										G	166231239	T	G	166231239	3	3	77	1	0	0	0	0	1	0	0	0	13916	1461	51	5	4195	5	SCN2A	2	166231239	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	5354606	166231239	76968134	69	23098										
SCN9A	6335	broad.mit.edu	37	chr2	167056069	167056069	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccagccagcagaggttgtaaTttggaacaggcaaatcatac	10	9	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:167056069T>C	uc010fpl.2	-	27	5388	c.5047A>G	c.(5047-5049)ATT>GTT	p.I1683V	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1694	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GAGGTTGTAATTTGGAACAGG	0.408													0	0	0	0.00874	0	34	95										C	167056069	T	C	167056069	3	2	77	1	0	0	0	0	1	0	0	0	13925	1493	52	5	890	5	SCN9A	2	167056069	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	824830	167056069	76143304	70	23099										
XIRP2	129446	broad.mit.edu	37	chr2	168100155	168100156	+	Missense_Mutation	DNP	GC	GC	AT													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agagatggttcgggccaaatGctggaaattaaaactgttca							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:168100155_168100156GC>AT	uc002udx.2	+	8	2271_2272	c.2253_2254GC>AT	c.(2251-2256)ATGCTG>ATATTG	p.M751I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.M576I|XIRP2_uc010fpq.2_Missense_Mutation_p.M529I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	576					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CGGGCCAAATGCTGGAAATTAA	0.366													0	0	0	0.004672	0	4	24										AT	168100156	GC	AT	168100155	3	1	77	1	0	0	0	0	1	0	0	0	17427	1319	46	2	2283	2	XIRP2	2	168100155	Missense_Mutation	DNP	GC	TCGA-FD-A3N5-01A-11D-A21A-08	1044086	168100155	75099218	71	23100										
TTN	7273	broad.mit.edu	37	chr2	179472309	179472309	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctttggtccatacttttgtAggtacagggcgaccagtcac	10	10	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:179472309A>C	uc010zfg.1	-	226	45626	c.45402T>G	c.(45400-45402)CCT>CCG	p.P15134P	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P8829P|TTN_uc010zfi.1_Silent_p.P8762P|TTN_uc010zfj.1_Silent_p.P8637P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16061							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTTTTGTAGGTACAGGGC	0.453													0	0	0	0.00361	0	41	134										C	179472309	A	C	179472309	2	2	77	1	0	0	0	0	0	0	0	1	16732	407	15	5		5	TTN	2	179472309	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	11372154	179472309	63727064	72	23101										
ZC3H15	55854	broad.mit.edu	37	chr2	187371546	187371546	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcttgaaagattcagcacatAtacttcagataaagatggta	7	6	3	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:187371546A>G	uc002upo.2	+	9	1298	c.1073A>G	c.(1072-1074)TAT>TGT	p.Y358C		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	358						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			TTCAGCACATATACTTCAGAT	0.313													0	0	0	0.00245	0	11	33										G	187371546	A	G	187371546	3	3	77	1	0	0	0	0	1	0	0	0	17564	449	16	5	1107	5	ZC3H15	2	187371546	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	7899237	187371546	55827827	73	23102										
ITGAV	3685	broad.mit.edu	37	chr2	187533614	187533614	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gatggaccaatgaactgcacTtcagatatggagatcaaccc	9	10	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:187533614T>C	uc002upq.2	+	25	2835	c.2559T>C	c.(2557-2559)ACT>ACC	p.T853T	ITGAV_uc010frs.2_Silent_p.T817T|ITGAV_uc010zfv.1_Silent_p.T807T	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	853	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TGAACTGCACTTCAGATATGG	0.343													0	0	0	0.00333	0	19	27										C	187533614	T	C	187533614	2	2	77	1	0	0	0	0	0	0	0	1	7888	1596	56	5		5	ITGAV	2	187533614	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	162068	187533614	55665759	74	23103										
MYO1B	4430	broad.mit.edu	37	chr2	192194756	192194756	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagtggagcaggaaaaacagGtaaggctcctaccaagcaac	11	9	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:192194756G>T	uc010fsg.2	+	4	601	c.346_splice	c.e4+1	p.E116_splice	MYO1B_uc002usq.2_Splice_Site_p.E116_splice|MYO1B_uc002usr.2_Splice_Site_p.E116_splice|MYO1B_uc002uss.1_Splice_Site_p.E116_splice	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1							myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GGAAAAACAGGTAAGGCTCCT	0.483													1	0	5.03518e-11	0.007413	5.37337e-11	19	25										T	192194756	G	T	192194756	5	4	77	1	0	0	0	0	0	0	1	0	10069	1275	44	4	357	4	MYO1B	2	192194756	Splice_Site	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4661142	192194756	51004617	75	23104										
SLC39A10	57181	broad.mit.edu	37	chr2	196581642	196581642	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcccctgtcattctggatccGatctgaaagaaacaggaata	9	10	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:196581642G>A	uc002utg.3	+	7	2192	c.1978G>A	c.(1978-1980)GAT>AAT	p.D660N	SLC39A10_uc002uth.3_Missense_Mutation_p.D660N|SLC39A10_uc010zgp.1_Missense_Mutation_p.D210N	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	660					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TTCTGGATCCGATCTGAAAGA	0.493													0	0	0	0.004007	0	15	70										A	196581642	G	A	196581642	3	1	77	1	0	0	0	0	1	0	0	0	14613	1058	37	1	2000	1	SLC39A10	2	196581642	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4386886	196581642	46617731	76	23105										
ALS2	57679	broad.mit.edu	37	chr2	202593268	202593268	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agggcatcattaaagagaatGaaccaattcacggaaaacct	8	8	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:202593268G>A	uc002uyo.2	-	15	3164	c.2808C>T	c.(2806-2808)TTC>TTT	p.F936F	ALS2_uc002uyp.3_Silent_p.F936F|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	936	PH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TAAAGAGAATGAACCAATTCA	0.488													0	0	0	0.001168	0	6	47										A	202593268	G	A	202593268	2	1	77	1	0	0	0	0	0	0	0	1	550	1281	45	1		1	ALS2	2	202593268	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	6011626	202593268	40606105	77	23106										
FZD7	8324	broad.mit.edu	37	chr2	202899544	202899544	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atctccatcccgctgtgcacGgacatcgcctacaaccagac	7	17	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:202899544G>C	uc002uyw.1	+	1	235	c.174G>C	c.(172-174)ACG>ACC	p.T58T		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	58	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						CGCTGTGCACGGACATCGCCT	0.672													0	0	0	0.00361	0	61	188										C	202899544	G	C	202899544	2	2	77	1	0	0	0	0	0	0	0	1	6135	1103	39	4		4	FZD7	2	202899544	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	306276	202899544	40299829	78	23107										
PTPRN	5798	broad.mit.edu	37	chr2	220166979	220166979	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctctggcagccttggcacccTggccctgctgggtgctggca	14	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:220166979T>C	uc002vkz.2	-	6	963	c.874A>G	c.(874-876)AGG>GGG	p.R292G	PTPRN_uc010zlc.1_Missense_Mutation_p.R202G|PTPRN_uc002vla.2_Missense_Mutation_p.R292G	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	292	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CTTGGCACCCTGGCCCTGCTG	0.632													0	0	0	0.00623	0	37	16										C	220166979	T	C	220166979	3	2	77	1	0	0	0	0	1	0	0	0	12807	1579	55	5	2137	5	PTPRN	2	220166979	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	17267435	220166979	23032394	79	23108										
COL4A3	1285	broad.mit.edu	37	chr2	228113226	228113226	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccccgggttgccaggggctcCaggaccccaggtacagcact	13	16	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:228113226C>T	uc002vom.1	+	9	698	c.536C>T	c.(535-537)CCA>CTA	p.P179L	COL4A3_uc002von.1_Missense_Mutation_p.P179L|COL4A3_uc002voo.1_Missense_Mutation_p.P179L|COL4A3_uc002vop.1_Missense_Mutation_p.P179L|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	179	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCAGGGGCTCCAGGACCCCAG	0.333													0	0	0	0.003163	0	12	6										T	228113226	C	T	228113226	3	4	77	1	0	0	0	0	1	0	0	0	3691	594	21	2	570	2	COL4A3	2	228113226	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	7946247	228113226	15086147	80	23109										
ALPI	248	broad.mit.edu	37	chr2	233322746	233322746	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acacgaaatatgagatccacCgagaccccacactggacccc	7	16	0	2	rs147248868		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:233322746C>T	uc002vst.3	+	8	972	c.895C>T	c.(895-897)CGA>TGA	p.R299*	ALPI_uc002vsu.3_Nonsense_Mutation_p.R210*	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	299					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGAGATCCACCGAGACCCCAC	0.617													0	0	0	0.00361	0	62	28										T	233322746	C	T	233322746	4	4	77	1	0	0	0	0	0	1	0	0	543	644	23	2	925	2	ALPI	2	233322746	Nonsense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5209520	233322746	9876627	81	23110										
USP40	55230	broad.mit.edu	37	chr2	234460031	234460031	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atagttcaaacctgttcacaAaagggcttgagattaatccg	8	8	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:234460031A>G	uc010zmu.1	-	7	946	c.828T>C	c.(826-828)TTT>TTC	p.F276F	USP40_uc010zmr.1_Silent_p.F288F|USP40_uc010zmt.1_5'Flank			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	276					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CCTGTTCACAAAAGGGCTTGA	0.323													0	0	0	0.006214	0	6	1										G	234460031	A	G	234460031	2	3	77	1	0	0	0	0	0	0	0	1	17069	11	1	5		5	USP40	2	234460031	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1137285	234460031	8739342	82	23111										
ESPNL	339768	broad.mit.edu	37	chr2	239039530	239039530	+	Frame_Shift_Del	DEL	G	G	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaggaggtgccatcagaggcGggtgccgcagccggcccaga					rs115923307	by1000genomes	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:239039530delG	uc002vxq.3	+	9	2285	c.2175delG	c.(2173-2175)GCGfs	p.A725fs	ESPNL_uc010fyw.2_Frame_Shift_Del_p.A421fs	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	725										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CATCAGAGGCGGGTGCCGCAG	0.682																		2	4	---	---								-	239039530	G	-	239039530	7	5	77	1	0	1	0	1	0	0	0	0	5255	1103	39	0	2209	0	ESPNL	2	239039530	Frame_Shift_Del	DEL	G	TCGA-FD-A3N5-01A-11D-A21A-08	4579499	239039530	4159843	83	23112										
KLHL30	377007	broad.mit.edu	37	chr2	239054468	239054468	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	caatggggagatctacgttaTcggcggtgaggccttcctct	13	10	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:239054468T>C	uc002vxr.1	+	4	1124	c.1091T>C	c.(1090-1092)ATC>ACC	p.I364T		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	382	Kelch 3.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		ATCTACGTTATCGGCGGTGAG	0.657													0	0	0	0.002445	0	25	7										C	239054468	T	C	239054468	3	2	77	1	0	0	0	0	1	0	0	0	8384	1435	50	5	1159	5	KLHL30	2	239054468	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	14938	239054468	4144905	84	23113										
EDEM1	9695	broad.mit.edu	37	chr3	5229970	5229970	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gagctcaaccccatccactgCcgcggccgtgggcccgaccg	12	19	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:5229970C>T	uc003bqi.2	+	1	612	c.480C>T	c.(478-480)TGC>TGT	p.C160C	EDEM1_uc011asz.1_5'UTR|EDEM1_uc003bqh.2_Silent_p.C160C	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	160	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		CCATCCACTGCCGCGGCCGTG	0.602													0	0	0	0.001882	0	16	31										T	5229970	C	T	5229970	2	4	77	1	0	0	0	0	0	0	0	1	4911	747	26	2		2	EDEM1	3	5229970	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		5229970	192792460	85	23114										
FBLN2	2199	broad.mit.edu	37	chr3	13659771	13659771	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctcactgcaggacgatggccGcacttgccgcccaggtaagg	13	14	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:13659771G>T	uc011avb.1	+	6	2050	c.1925G>T	c.(1924-1926)CGC>CTC	p.R642L	FBLN2_uc011auz.1_Missense_Mutation_p.R668L|FBLN2_uc011ava.1_Missense_Mutation_p.R642L|FBLN2_uc011avc.1_Missense_Mutation_p.R642L	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	642	EGF-like 1; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GACGATGGCCGCACTTGCCGC	0.617													1	0	3.62473e-10	0.001882	3.83953e-10	19	50										T	13659771	G	T	13659771	3	4	77	1	0	0	0	0	1	0	0	0	5699	1087	38	4	633	4	FBLN2	3	13659771	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	8429801	13659771	184362659	86	23115										
ANKRD28	23243	broad.mit.edu	37	chr3	15727600	15727600	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaacacagtctgtgtgcccgTtgagaacagatagcatcaga	10	9	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:15727600T>G	uc003caj.1	-	20	2131	c.1988A>C	c.(1987-1989)AAC>ACC	p.N663T	ANKRD28_uc003cai.1_Missense_Mutation_p.N509T|ANKRD28_uc011avz.1_Missense_Mutation_p.N509T|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.N693T|ANKRD28_uc003cam.2_Missense_Mutation_p.N696T	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	663	ANK 19.					nucleoplasm	protein binding			breast(1)	1						TGTGTGCCCGTTGAGAACAGA	0.468													0	0	0	0.001168	0	5	12										G	15727600	T	G	15727600	3	3	77	1	0	0	0	0	1	0	0	0	656	1725	60	5	1209	5	ANKRD28	3	15727600	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2067829	15727600	182294830	87	23116										
ZNF385D	79750	broad.mit.edu	37	chr3	21478519	21478519	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agcaaccttgcatagcgaacAgtaaagaagccgttttgcct	9	10	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:21478519A>T	uc003cce.2	-	5	1024	c.616T>A	c.(616-618)TGT>AGT	p.C206S	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	206	Matrin-type 2.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CATAGCGAACAGTAAAGAAGC	0.483													0	0	0	0.007413	0	14	44										T	21478519	A	T	21478519	3	4	77	1	0	0	0	0	1	0	0	0	17875	188	7	5	587	5	ZNF385D	3	21478519	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5750919	21478519	176543911	88	23117										
SCAP	22937	broad.mit.edu	37	chr3	47484415	47484415	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atgatggggatgggataggaTgcacagaggagcccatggtt	17	5	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:47484415T>C	uc003crh.1	-	2	324	c.69A>G	c.(67-69)GCA>GCG	p.A23A	SCAP_uc011baz.1_5'UTR|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	23	Helical; Name=1; (Potential).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		TGGGATAGGATGCACAGAGGA	0.542													0	0	0	0.001168	0	5	18										C	47484415	T	C	47484415	2	2	77	1	0	0	0	0	0	0	0	1	13877	1451	51	5		5	SCAP	3	47484415	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	26005896	47484415	150538015	89	23118										
RBM5	10181	broad.mit.edu	37	chr3	50144929	50144929	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tttcagagacttggtcctctCagatggtaaccgcgtcagcg	11	11	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:50144929C>T	uc003cyg.2	+	12	1116	c.968C>T	c.(967-969)TCA>TTA	p.S323L	RBM5_uc011bdj.1_Missense_Mutation_p.S267L|RBM5_uc011bdk.1_Missense_Mutation_p.S151L	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	323	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTGGTCCTCTCAGATGGTAAC	0.478													0	0	0	0.000978	0	9	21										T	50144929	C	T	50144929	3	4	77	1	0	0	0	0	1	0	0	0	13143	838	29	1	1010	1	RBM5	3	50144929	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2660514	50144929	147877501	90	23119										
GRAMD1C	54762	broad.mit.edu	37	chr3	113563350	113563350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agtttgatatttgtttccagGtgatgaatgaaggggattca	12	3	1	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:113563350G>A	uc003eaq.3	+	2	104	c.28G>A	c.(28-30)GTG>ATG	p.V10M	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	10						integral to membrane				ovary(2)|skin(1)	3						TTGTTTCCAGGTGATGAATGA	0.323													0	0	0	0.006214	0	9	20										A	113563350	G	A	113563350	3	1	77	1	0	0	0	0	1	0	0	0	6749	1275	44	2	34	2	GRAMD1C	3	113563350	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	63418421	113563350	84459080	91	23120										
ITGB5	3693	broad.mit.edu	37	chr3	124540305	124540305	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcaaatgcagtgcatcctttCgccagccaatcttctcctga	7	14	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:124540305C>T	uc003eho.2	-	6	1094	c.797G>A	c.(796-798)CGA>CAA	p.R266Q		NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	266	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		TGCATCCTTTCGCCAGCCAAT	0.567													0	0	0	0.003755	0	31	149										T	124540305	C	T	124540305	3	4	77	1	0	0	0	0	1	0	0	0	7898	884	31	1	1642	1	ITGB5	3	124540305	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	10976955	124540305	73482125	92	23121										
COL6A6	131873	broad.mit.edu	37	chr3	130381085	130381085	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	caccacctggtccagcttggCcgaattcataaacctgacca	7	15	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:130381085C>G	uc010htl.2	+	34	6466	c.6435C>G	c.(6433-6435)GGC>GGG	p.G2145G	COL6A6_uc003eni.3_Silent_p.G244G	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2145	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCCAGCTTGGCCGAATTCATA	0.448													0	0	0	0.005443	0	18	116										G	130381085	C	G	130381085	2	3	77	1	0	0	0	0	0	0	0	1	3703	726	26	4		4	COL6A6	3	130381085	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5840780	130381085	67641345	93	23122										
NPHP3	27031	broad.mit.edu	37	chr3	132408036	132408036	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	actgcttcaatgaatcgaagTattctgttgccattgcactt	7	9	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:132408036T>A	uc003epe.1	-	20	2842	c.2765A>T	c.(2764-2766)TAC>TTC	p.Y922F	NPHP3_uc003epd.1_Missense_Mutation_p.Y164F	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	922	TPR 3.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						TGAATCGAAGTATTCTGTTGC	0.408													0	0	0	0.002522	0	38	30										A	132408036	T	A	132408036	3	1	77	1	0	0	0	0	1	0	0	0	10580	1638	57	5	1259	5	NPHP3	3	132408036	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2026951	132408036	65614394	94	23123										
CLSTN2	64084	broad.mit.edu	37	chr3	140277676	140277676	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	caccttcgccaaaaccgaagCccccggggacgtgaaaacca	9	16	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:140277676C>G	uc003etn.2	+	12	2208	c.2018C>G	c.(2017-2019)GCC>GGC	p.A673G		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	673	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AAAACCGAAGCCCCCGGGGAC	0.502										HNSCC(16;0.037)			0	0	0	0.008871	0	17	26										G	140277676	C	G	140277676	3	3	77	1	0	0	0	0	1	0	0	0	3562	739	26	4	2064	4	CLSTN2	3	140277676	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	7869640	140277676	57744754	95	23124										
HPS3	84343	broad.mit.edu	37	chr3	148889891	148889891	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tttctacacagaaacattgtCaattgttgctgtggaactag	8	7	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:148889891C>G	uc003ewu.1	+	17	3037	c.2897C>G	c.(2896-2898)TCA>TGA	p.S966*	CP_uc011bnr.1_Intron|HPS3_uc011bnq.1_Nonsense_Mutation_p.S801*|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	966						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GAAACATTGTCAATTGTTGCT	0.353									Hermansky-Pudlak_syndrome				0	0	0	0.00333	0	22	14										G	148889891	C	G	148889891	4	3	77	1	0	0	0	0	0	1	0	0	7340	838	29	1	2963	1	HPS3	3	148889891	Nonsense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	8612215	148889891	49132539	96	23125										
FNDC3B	64778	broad.mit.edu	37	chr3	172064198	172064198	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagcaccttgtatttcttgtAcacctgatggatgtgtctta	8	8	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:172064198A>T	uc003fhy.2	+	20	2504	c.2332A>T	c.(2332-2334)ACA>TCA	p.T778S	FNDC3B_uc003fhz.3_Missense_Mutation_p.T778S	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	778	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TATTTCTTGTACACCTGATGG	0.423													0	0	0	0.00278	0	17	68										T	172064198	A	T	172064198	3	4	77	1	0	0	0	0	1	0	0	0	5970	391	14	5	2406	5	FNDC3B	3	172064198	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	23174307	172064198	25958232	97	23126										
TNFSF10	8743	broad.mit.edu	37	chr3	172227013	172227013	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gttgtttctcttacttggagAagacaatgtgttgcttcttc	9	7	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:172227013A>G	uc003fid.2	-	4	507	c.412T>C	c.(412-414)TCT>CCT	p.S138P	TNFSF10_uc003fie.2_Intron	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	138	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TTACTTGGAGAAGACAATGTG	0.358													0	0	0	0.001984	0	5	28										G	172227013	A	G	172227013	3	3	77	1	0	0	0	0	1	0	0	0	16298	246	9	5	441	5	TNFSF10	3	172227013	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	162815	172227013	25795417	98	23127										
LEPREL1	55214	broad.mit.edu	37	chr3	189690704	189690704	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccatgtgtgtataggaaaaaTacagagttgagttcagcata	10	5	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:189690704T>C	uc011bsk.1	-	11	2046	c.1658A>G	c.(1657-1659)TAT>TGT	p.Y553C	LEPREL1_uc003fsg.2_Missense_Mutation_p.Y372C	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	553					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATAGGAAAAATACAGAGTTGA	0.433													0	0	0	0.004289	0	31	21										C	189690704	T	C	189690704	3	2	77	1	0	0	0	0	1	0	0	0	8730	1406	49	5	488	5	LEPREL1	3	189690704	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	17463691	189690704	8331726	99	23128										
MUC20	200958	broad.mit.edu	37	chr3	195453217	195453217	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agcccctcggaagccgccctCaagaacttcaccccttcaga	7	18	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:195453217C>G	uc010hzo.2	+	3	1356	c.1230C>G	c.(1228-1230)CTC>CTG	p.L410L	MUC20_uc010hzp.2_Silent_p.L375L|MUC20_uc011bte.1_RNA	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	581	Involved in oligomerization.				protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		AAGCCGCCCTCAAGAACTTCA	0.597													0	0	0	0.004007	0	14	105										G	195453217	C	G	195453217	2	3	77	1	0	0	0	0	0	0	0	1	9976	813	29	1		1	MUC20	3	195453217	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5762513	195453217	2569213	100	23129										
MUC4	4585	broad.mit.edu	37	chr3	195512568	195512568	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaggtggcgtgacctgtgggTactgaggaagcgtcggtgac	19	7	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:195512568T>C	uc011bto.1	-	2	6343	c.5883A>G	c.(5881-5883)GTA>GTG	p.V1961V	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACCTGTGGGTACTGAGGAAG	0.602													0	0	0	0.004672	0	2	6										C	195512568	T	C	195512568	2	2	77	1	0	0	0	0	0	0	0	1	9978	1625	57	5		5	MUC4	3	195512568	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	59351	195512568	2509862	101	23130										
HGFAC	3083	broad.mit.edu	37	chr4	3449359	3449359	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccccagcgaccacgacctcgGtgagctccggcgtgtcgtgg	14	16	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:3449359G>A	uc003ghc.2	+	11	1498	c.1495_splice	c.e11+1	p.V499_splice	HGFAC_uc010icw.2_Splice_Site_p.V506_splice	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein						proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CACGACCTCGGTGAGCTCCGG	0.652													0	0	0	0.00361	0	216	288										A	3449359	G	A	3449359	5	1	77	1	0	0	0	0	0	0	1	0	7086	1275	44	2	1538	2	HGFAC	4	3449359	Splice_Site	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08		3449359	187704917	102	23131										
FBXL5	26234	broad.mit.edu	37	chr4	15626988	15626988	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taaattaagtcttttcccctAggcaatctagtccttgctgc	6	11	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:15626988A>C	uc003goc.1	-	9	1840	c.1737T>G	c.(1735-1737)CCT>CCG	p.P579P	FBXL5_uc010idw.1_Silent_p.P492P|FBXL5_uc003gob.1_Silent_p.P453P|FBXL5_uc010idx.1_Silent_p.P578P|FBXL5_uc003god.1_Silent_p.P562P|FBXL5_uc010idy.1_Silent_p.P579P	NM_012161	NP_036293	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5 isoform	579	LRR 5.				iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0						CTTTTCCCCTAGGCAATCTAG	0.398													0	0	0	0.006214	0	8	10										C	15626988	A	C	15626988	2	2	77	1	0	0	0	0	0	0	0	1	5722	407	15	5		5	FBXL5	4	15626988	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	12177629	15626988	175527288	103	23132										
ARAP2	116984	broad.mit.edu	37	chr4	36231078	36231078	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctcattaggaaatcttttaTatccacatttacttcactga	4	9	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:36231078T>C	uc003gsq.1	-	2	369	c.31A>G	c.(31-33)ATA>GTA	p.I11V	ARAP2_uc003gsr.1_Missense_Mutation_p.I11V	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	11	SAM.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAATCTTTTATATCCACATTT	0.383													0	0	0	0.000978	0	8	35										C	36231078	T	C	36231078	3	2	77	1	0	0	0	0	1	0	0	0	839	1406	49	5	5211	5	ARAP2	4	36231078	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	20604090	36231078	154923198	104	23133										
KCTD8	386617	broad.mit.edu	37	chr4	44177154	44177154	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctctgaatggctgtcacaacTggaagtggagagctcattac	11	9	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:44177154T>C	uc003gwu.2	-	2	1359	c.1075A>G	c.(1075-1077)AGT>GGT	p.S359G		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	359						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						CTGTCACAACTGGAAGTGGAG	0.468										HNSCC(17;0.042)			0	0	0	0.007413	0	17	38										C	44177154	T	C	44177154	3	2	77	1	0	0	0	0	1	0	0	0	8115	1580	55	5	350	5	KCTD8	4	44177154	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	7946076	44177154	146977122	105	23134										
FRYL	285527	broad.mit.edu	37	chr4	48577219	48577219	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agaacgcatcattggaactaTgtgcttaaacaaggatgaag	10	6	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:48577219T>C	uc003gyh.1	-	25	3366	c.2761A>G	c.(2761-2763)ATA>GTA	p.I921V	FRYL_uc003gyk.2_Missense_Mutation_p.I921V	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	921					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						ATTGGAACTATGTGCTTAAAC	0.398													0	0	0	0.000602	0	5	28										C	48577219	T	C	48577219	3	2	77	1	0	0	0	0	1	0	0	0	6064	1464	51	5	6440	5	FRYL	4	48577219	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	4400065	48577219	142577057	106	23135										
OCIAD1	54940	broad.mit.edu	37	chr4	48859275	48859275	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcctaaaagaaaaaatattaCatatgaggaattaaggaata	6	3	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:48859275C>G	uc003gyo.2	+	8	850	c.593C>G	c.(592-594)ACA>AGA	p.T198R	OCIAD1_uc003gyr.2_Missense_Mutation_p.T198R|OCIAD1_uc003gyp.2_Intron|OCIAD1_uc003gys.2_Intron|OCIAD1_uc003gyq.2_Intron|OCIAD1_uc010igk.2_Missense_Mutation_p.T203R	NM_017830	NP_060300	Q9NX40	OCAD1_HUMAN	OCIA domain containing 1 isoform 1	198						endosome	protein binding				0						AAAAATATTACATATGAGGAA	0.333													0	0	0	0.001984	0	5	6										G	48859275	C	G	48859275	3	3	77	1	0	0	0	0	1	0	0	0	10817	478	17	4	655	4	OCIAD1	4	48859275	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	282056	48859275	142295001	107	23136										
SCFD2	152579	broad.mit.edu	37	chr4	54232001	54232001	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtggatccgcagccccagtgCaggctctcggcgcaggcggc	16	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:54232001C>A	uc003gzu.2	-	1	242	c.108G>T	c.(106-108)CTG>CTT	p.L36L	SCFD2_uc010igm.2_Silent_p.L36L	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	36					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AGCCCCAGTGCAGGCTCTCGG	0.652													1	0	1.43161e-34	0.00361	1.63341e-34	67	64										A	54232001	C	A	54232001	2	1	77	1	0	0	0	0	0	0	0	1	13890	697	25	4		4	SCFD2	4	54232001	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5372726	54232001	136922275	108	23137										
ODAM	54959	broad.mit.edu	37	chr4	71068501	71068501	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agaagagataccatatttacAaaaagaagcgatcaacttta	6	6	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:71068501A>G	uc003hfc.2	+	9	694	c.677A>G	c.(676-678)CAA>CGA	p.Q226R		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	226					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						CCATATTTACAAAAAGAAGCG	0.388													0	0	0	0.00308	0	7	13										G	71068501	A	G	71068501	3	3	77	1	0	0	0	0	1	0	0	0	10824	130	5	5	711	5	ODAM	4	71068501	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	16836500	71068501	120085775	109	23138										
GRSF1	2926	broad.mit.edu	37	chr4	71693625	71693625	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaatatcctcatttacttcaTgttcttcaaagaccatttct	3	10	5	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:71693625T>C	uc010iia.1	-	6	1162	c.1079A>G	c.(1078-1080)CAT>CGT	p.H360R	GRSF1_uc011caz.1_Missense_Mutation_p.H242R|GRSF1_uc003hfs.2_Missense_Mutation_p.H198R	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	360					mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			ATTTACTTCATGTTCTTCAAA	0.383													0	0	0	0.002299	0	19	50										C	71693625	T	C	71693625	3	2	77	1	0	0	0	0	1	0	0	0	6809	1464	51	5	379	5	GRSF1	4	71693625	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	625124	71693625	119460651	110	23139										
WDFY3	23001	broad.mit.edu	37	chr4	85731400	85731400	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtggacagctcaaagatcttTccatagcaacgagcaaggat	10	9	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:85731400T>C	uc003hpd.2	-	14	2393	c.1985A>G	c.(1984-1986)GAA>GGA	p.E662G	WDFY3_uc003hpf.2_Missense_Mutation_p.E662G	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	662						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAAAGATCTTTCCATAGCAAC	0.458													0	0	0	0.001368	0	10	29										C	85731400	T	C	85731400	3	2	77	1	0	0	0	0	1	0	0	0	17267	1783	62	5	8858	5	WDFY3	4	85731400	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	14037775	85731400	105422876	111	23140										
PDE5A	8654	broad.mit.edu	37	chr4	120446823	120446823	+	Frame_Shift_Del	DEL	G	G	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctaaagtcagtaattttaaGggtctgggcagatggcacca							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:120446823delG	uc003idh.2	-	12	1815	c.1660delC	c.(1660-1662)CTTfs	p.L554fs	uc003ide.3_Intron|PDE5A_uc003idf.2_Frame_Shift_Del_p.L512fs|PDE5A_uc003idg.2_Frame_Shift_Del_p.L502fs|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	554					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GTAATTTTAAGGGTCTGGGCA	0.408																		15	47	---	---								-	120446823	G	-	120446823	7	5	77	1	0	1	0	1	0	0	0	0	11644	1000	35	0	1007	0	PDE5A	4	120446823	Frame_Shift_Del	DEL	G	TCGA-FD-A3N5-01A-11D-A21A-08	34715423	120446823	70707453	112	23141										
ANKRD50	57182	broad.mit.edu	37	chr4	125590169	125590169	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggtgtttcctttttatagttGaagctagggtcagaaccttc	10	7	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:125590169G>C	uc003ifg.3	-	3	4529	c.4263C>G	c.(4261-4263)TTC>TTG	p.F1421L	ANKRD50_uc011cgo.1_Missense_Mutation_p.F1242L|ANKRD50_uc010inw.2_Missense_Mutation_p.F1421L	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1421										central_nervous_system(1)	1						TTTTATAGTTGAAGCTAGGGT	0.318													0	0	0	0.009096	0	4	4										C	125590169	G	C	125590169	3	2	77	1	0	0	0	0	1	0	0	0	677	1281	45	1	30	1	ANKRD50	4	125590169	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5143346	125590169	65564107	113	23142										
PCDH18	54510	broad.mit.edu	37	chr4	138452651	138452651	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taactctctgaccactatgaGttctgcatacttggctccat	6	12	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:138452651G>A	uc003ihe.3	-	1	979	c.592C>T	c.(592-594)CTC>TTC	p.L198F	PCDH18_uc003ihf.3_Missense_Mutation_p.L191F|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_5'UTR|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	198	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					ACCACTATGAGTTCTGCATAC	0.488													0	0	0	0.00308	0	8	30										A	138452651	G	A	138452651	3	1	77	1	0	0	0	0	1	0	0	0	11513	1029	36	2	2831	2	PCDH18	4	138452651	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	12862482	138452651	52701625	114	23143										
FNIP2	57600	broad.mit.edu	37	chr4	159789770	159789770	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taaagaggcaccgcaagatgGctcttcaagacttcccagct	9	12	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:159789770G>T	uc003iqe.3	+	13	2165	c.1982G>T	c.(1981-1983)GGC>GTC	p.G661V		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	661	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CCGCAAGATGGCTCTTCAAGA	0.522													1	0	1.49906e-05	0.00245	1.53851e-05	14	13										T	159789770	G	T	159789770	3	4	77	1	0	0	0	0	1	0	0	0	5976	1203	42	4	2032	4	FNIP2	4	159789770	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	21337119	159789770	31364506	115	23144										
FSTL5	56884	broad.mit.edu	37	chr4	162697123	162697123	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agcttcttccgagatatgtcGtcgccattaggattttcatt	8	9	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:162697123G>A	uc003iqh.2	-	5	949	c.513C>T	c.(511-513)GAC>GAT	p.D171D	FSTL5_uc003iqi.2_Silent_p.D170D|FSTL5_uc010iqv.2_Silent_p.D170D	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	171						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GAGATATGTCGTCGCCATTAG	0.303													0	0	0	0.000602	0	5	9										A	162697123	G	A	162697123	2	1	77	1	0	0	0	0	0	0	0	1	6080	1136	40	2		2	FSTL5	4	162697123	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2907353	162697123	28457153	116	23145										
ANP32C	23520	broad.mit.edu	37	chr4	165118190	165118191	+	Missense_Mutation	DNP	CC	CC	AG													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctgacccctttcttcttcaCcaagctcttcttcatcttcc							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:165118190_165118191CC>AG	uc011cjk.1	-	1	673_674	c.673_674GG>CT	c.(673-675)GGT>CTT	p.G225L	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	225	Asp/Glu-rich (highly acidic).										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		ttcttcttcaccaagctcttct	0.035													0	0	0	0.004672	0	8	6										AG	165118191	CC	AG	165118190	3	1	77	1	0	0	0	0	1	0	0	0	707	507	18	4	33	4	ANP32C	4	165118190	Missense_Mutation	DNP	CC	TCGA-FD-A3N5-01A-11D-A21A-08	2421067	165118190	26036086	117	23146										
PDZD2	23037	broad.mit.edu	37	chr5	32048677	32048677	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccttgagtcagttgaagaaTataacgagctgatggtgcgg	14	6	1	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:32048677T>C	uc003jhl.2	+	8	1940	c.1552T>C	c.(1552-1554)TAT>CAT	p.Y518H	PDZD2_uc003jhm.2_Missense_Mutation_p.Y518H|PDZD2_uc011cnx.1_Missense_Mutation_p.Y344H	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	518					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGTTGAAGAATATAACGAGCT	0.527													0	0	0	0.00361	0	51	46										C	32048677	T	C	32048677	3	2	77	1	0	0	0	0	1	0	0	0	11701	1406	49	5	1578	5	PDZD2	5	32048677	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08		32048677	148866583	118	23147										
PDZD2	23037	broad.mit.edu	37	chr5	32089375	32089375	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggctccatgtagccgaccacGaggaccctgacagaaacacc	10	15	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:32089375G>T	uc003jhl.2	+	20	6209	c.5821G>T	c.(5821-5823)GAG>TAG	p.E1941*	PDZD2_uc003jhm.2_Nonsense_Mutation_p.E1941*	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1941					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGCCGACCACGAGGACCCTGA	0.602													1	0	1.26289e-39	0.00361	1.44861e-39	96	88										T	32089375	G	T	32089375	4	4	77	1	0	0	0	0	0	1	0	0	11701	1059	37	3	5895	3	PDZD2	5	32089375	Nonsense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	40698	32089375	148825885	119	23148										
SPEF2	79925	broad.mit.edu	37	chr5	35779431	35779431	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagtcttcgagatcagttctTagatatggcacctaaaggta	9	8	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:35779431T>G	uc003jjo.2	+	30	4541	c.4430T>G	c.(4429-4431)TTA>TGA	p.L1477*	SPEF2_uc003jjp.1_Nonsense_Mutation_p.L963*|SPEF2_uc003jjr.2_5'UTR	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1477					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATCAGTTCTTAGATATGGCA	0.398													0	0	0	0.004878	0	31	26										G	35779431	T	G	35779431	4	3	77	1	0	0	0	0	0	1	0	0	15034	1764	61	5	4569	5	SPEF2	5	35779431	Nonsense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	3690056	35779431	145135829	120	23149										
C7	730	broad.mit.edu	37	chr5	40972587	40972587	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tacacagttggtgagaaggtGactgtttcctgttcaggtgg	14	6	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:40972587G>C	uc003jmh.2	+	15	2079	c.1965G>C	c.(1963-1965)GTG>GTC	p.V655V	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	655	Sushi 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GTGAGAAGGTGACTGTTTCCT	0.473													0	0	0	0.00308	0	7	70										C	40972587	G	C	40972587	2	2	77	1	0	0	0	0	0	0	0	1	2375	1277	45	1		1	C7	5	40972587	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5193156	40972587	139942673	121	23150										
HEATR7B2	133558	broad.mit.edu	37	chr5	41045898	41045898	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	catttgctgtttgaaatcctGagtcagctgaatggtccagg	11	8	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:41045898G>C	uc003jmj.3	-	18	2276	c.1786C>G	c.(1786-1788)CAG>GAG	p.Q596E	HEATR7B2_uc003jmi.3_Missense_Mutation_p.Q151E	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	596	HEAT 7.						binding			ovary(6)|central_nervous_system(2)	8						TTGAAATCCTGAGTCAGCTGA	0.388													0	0	0	0.00361	0	112	93										C	41045898	G	C	41045898	3	2	77	1	0	0	0	0	1	0	0	0	7035	1299	45	1	3071	1	HEATR7B2	5	41045898	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	73311	41045898	139869362	122	23151										
MGC42105	167359	broad.mit.edu	37	chr5	43277375	43277375	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cactgaggggaagctctctgAaccagaaagcaagctcatct	10	11	3	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:43277375A>T	uc003jno.2	+	3	1390	c.509A>T	c.(508-510)GAA>GTA	p.E170V		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	170	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						AAGCTCTCTGAACCAGAAAGC	0.532													0	0	0	0.00623	0	29	77										T	43277375	A	T	43277375	3	4	77	1	0	0	0	0	1	0	0	0	9552	246	9	5	515	5	MGC42105	5	43277375	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	2231477	43277375	137637885	123	23152										
F2RL1	2150	broad.mit.edu	37	chr5	76129480	76129480	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctattactttgtttcacatGatttcagggatcatgcaaag	7	7	4	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:76129480G>C	uc003keo.2	+	2	1223	c.1048G>C	c.(1048-1050)GAT>CAT	p.D350H		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	350	Cytoplasmic (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		TGTTTCACATGATTTCAGGGA	0.488													0	0	0	0.00361	0	129	53										C	76129480	G	C	76129480	3	2	77	1	0	0	0	0	1	0	0	0	5344	1290	45	1	1054	1	F2RL1	5	76129480	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	32852105	76129480	104785780	124	23153										
PJA2	9867	broad.mit.edu	37	chr5	108680459	108680459	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaccatcaatgctttccttaCtagctggtggattggccacc	9	12	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:108680459C>G	uc003kos.3	-	8	2046	c.1826G>C	c.(1825-1827)AGT>ACT	p.S609T		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	609	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		GCTTTCCTTACTAGCTGGTGG	0.413													0	0	0	0.003755	0	26	22										G	108680459	C	G	108680459	3	3	77	1	0	0	0	0	1	0	0	0	11962	565	20	4	312	4	PJA2	5	108680459	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	32550979	108680459	72234801	125	23154										
CHSY3	337876	broad.mit.edu	37	chr5	129520908	129520908	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaaatgaccctgatcccaatGaagggagagttttccagagg	12	8	0	5			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:129520908G>A	uc003kvd.2	+	3	2073	c.2073G>A	c.(2071-2073)ATG>ATA	p.M691I		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	691	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		TGATCCCAATGAAGGGAGAGT	0.443													0	0	0	0.00245	0	15	5										A	129520908	G	A	129520908	3	1	77	1	0	0	0	0	1	0	0	0	3413	1290	45	1	2083	1	CHSY3	5	129520908	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	20840449	129520908	51394352	126	23155										
FNIP1	96459	broad.mit.edu	37	chr5	131008068	131008068	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	actctgacaatgcacatttgTctactggaacagatcctgtg	8	10	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:131008068T>C	uc003kvs.1	-	14	2211	c.2069A>G	c.(2068-2070)GAC>GGC	p.D690G	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.D662G|FNIP1_uc010jdm.1_Missense_Mutation_p.D645G	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	690					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TGCACATTTGTCTACTGGAAC	0.418													0	0	0	0.00361	0	75	38										C	131008068	T	C	131008068	3	2	77	1	0	0	0	0	1	0	0	0	5975	1667	58	5	1451	5	FNIP1	5	131008068	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1487160	131008068	49907192	127	23156										
ARHGAP26	23092	broad.mit.edu	37	chr5	142513586	142513586	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atgcccagctgcacctgtctCggaagaagagcagtgactcc	11	13	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:142513586C>G	uc011dbj.1	+	19	1788	c.1753C>G	c.(1753-1755)CGG>GGG	p.R585G	ARHGAP26_uc003lmt.2_Missense_Mutation_p.R585G|ARHGAP26_uc003lmw.2_Missense_Mutation_p.R585G	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	585	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACCTGTCTCGGAAGAAGAG	0.537													0	0	0	0.00361	0	125	41										G	142513586	C	G	142513586	3	3	77	1	0	0	0	0	1	0	0	0	875	875	31	1	1827	1	ARHGAP26	5	142513586	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	11505518	142513586	38401674	128	23157										
FAT2	2196	broad.mit.edu	37	chr5	150947267	150947267	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgatcaacccagttcgagcaTtaagtttaaatcctacattc	5	10	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:150947267T>A	uc003lue.3	-	1	1239	c.1226A>T	c.(1225-1227)AAT>ATT	p.N409I	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.N409I	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	409	Extracellular (Potential).|Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTTCGAGCATTAAGTTTAAA	0.537													0	0	0	0.002445	0	30	9										A	150947267	T	A	150947267	3	1	77	1	0	0	0	0	1	0	0	0	5690	1493	52	5	11915	5	FAT2	5	150947267	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	8433681	150947267	29967993	129	23158										
CNOT8	9337	broad.mit.edu	37	chr5	154250228	154250228	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccttgttttttagagaggacAtgtactcccaggattccata	8	9	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:154250228A>G	uc003lvu.2	+	5	798	c.319A>G	c.(319-321)ATG>GTG	p.M107V	CNOT8_uc011ddf.1_Missense_Mutation_p.M1V|CNOT8_uc011ddg.1_Missense_Mutation_p.M1V|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.M107V|CNOT8_uc010jig.2_Missense_Mutation_p.M1V|CNOT8_uc010jif.2_Missense_Mutation_p.M1V|CNOT8_uc003lvw.2_Missense_Mutation_p.M107V|CNOT8_uc011ddi.1_Missense_Mutation_p.M1V|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	107					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAGAGAGGACATGTACTCCCA	0.398								Direct_reversal_of_damage					0	0	0	0.006122	0	16	7										G	154250228	A	G	154250228	3	3	77	1	0	0	0	0	1	0	0	0	3625	217	8	5	329	5	CNOT8	5	154250228	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	3302961	154250228	26665032	130	23159										
HIST1H2AG	8969	broad.mit.edu	37	chr6	27101228	27101228	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagactgagagccaccacaaGgcgaagggcaagtaactatc	11	10	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:27101228G>A	uc003niw.2	+	1	412	c.378G>A	c.(376-378)AAG>AAA	p.K126K	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	126					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GCCACCACAAGGCGAAGGGCA	0.522													0	0	0	0.004289	0	32	61										A	27101228	G	A	27101228	2	1	77	1	0	0	0	0	0	0	0	1	7133	991	35	2		2	HIST1H2AG	6	27101228	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08		27101228	144013839	131	23160										
TRIM31	11074	broad.mit.edu	37	chr6	30071549	30071549	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agagtggtgatttggtggccCcgatgtagttctgccgcctt	14	9	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:30071549C>T	uc003npg.1	-	9	1152	c.1042G>A	c.(1042-1044)GGG>AGG	p.G348R	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	348						mitochondrion	ligase activity|zinc ion binding			lung(1)	1						TTTGGTGGCCCCGATGTAGTT	0.567													0	0	0	0.00361	0	42	128										T	30071549	C	T	30071549	3	4	77	1	0	0	0	0	1	0	0	0	16502	623	22	2	239	2	TRIM31	6	30071549	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2970321	30071549	141043518	132	23161										
MDC1	9656	broad.mit.edu	37	chr6	30672554	30672554	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccctagtagcctgagacgtaGgctcaggggtaacaggctgg	15	10	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:30672554G>T	uc003nrg.3	-	10	4846	c.4406C>A	c.(4405-4407)CCT>CAT	p.P1469H	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.P1076H	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1469	Pro-rich.|Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTGAGACGTAGGCTCAGGGGT	0.562								Other_conserved_DNA_damage_response_genes					1	0	4.21773e-46	0.00361	4.864e-46	81	108										T	30672554	G	T	30672554	3	4	77	1	0	0	0	0	1	0	0	0	9403	1000	35	4	1887	4	MDC1	6	30672554	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	601005	30672554	140442513	133	23162										
HLA-C	3107	broad.mit.edu	37	chr6	31239079	31239079	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tacccgcggaggaggcgcccGtcgggccccaggtcgcagcc	16	17	0	0	rs45558335		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:31239079G>A	uc003nsy.2	-	3	397	c.390C>T	c.(388-390)GAC>GAT	p.D130D	HLA-C_uc011dnj.1_Silent_p.D102D|HLA-C_uc003nsx.2_Silent_p.D9D|HLA-C_uc003nsz.2_Silent_p.D130D|HLA-C_uc010jsl.2_Silent_p.D130D|HLA-C_uc003nta.2_Silent_p.D130D|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_Silent_p.D9D|HLA-B_uc003ntf.2_Silent_p.D130D	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	130	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						GGAGGCGCCCGTCGGGCCCCA	0.741													0	0	0	0.00361	0	25	190										A	31239079	G	A	31239079	2	1	77	1	0	0	0	0	0	0	0	1	7197	1136	40	2		2	HLA-C	6	31239079	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	566525	31239079	139875988	134	23163										
NOTCH4	4855	broad.mit.edu	37	chr6	32169985	32169985	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggcagcccttccaggggtctGggactcccagagagcagtcc	14	14	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:32169985G>T	uc003obb.2	-	21	3762	c.3623C>A	c.(3622-3624)CCA>CAA	p.P1208Q	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1208	LNR 1.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CCAGGGGTCTGGGACTCCCAG	0.637													1	0	2.84431e-33	0.00361	3.22806e-33	79	114										T	32169985	G	T	32169985	3	4	77	1	0	0	0	0	1	0	0	0	10551	1348	47	4	2428	4	NOTCH4	6	32169985	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	930906	32169985	138945082	135	23164										
ITPR3	3710	broad.mit.edu	37	chr6	33623613	33623613	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tactggaaggccaagcagacTaagcaggacaaggagaagat	13	7	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:33623613T>C	uc011drk.1	+	3	450	c.231T>C	c.(229-231)ACT>ACC	p.T77T		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	77	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CCAAGCAGACTAAGCAGGACA	0.572													0	0	0	0.00361	0	52	71										C	33623613	T	C	33623613	2	2	77	1	0	0	0	0	0	0	0	1	7922	1509	53	5		5	ITPR3	6	33623613	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1453628	33623613	137491454	136	23165										
STK38	11329	broad.mit.edu	37	chr6	36483157	36483157	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctggtttgatgtctctgtgGatgaatccaagttggtgaat	12	5	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:36483157G>A	uc003omg.2	-	6	1215	c.627C>T	c.(625-627)ATC>ATT	p.I209I	STK38_uc003omh.2_Silent_p.I209I|STK38_uc003omi.2_Silent_p.I209I	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	209	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						TGTCTCTGTGGATGAATCCAA	0.433													0	0	0	0.00623	0	32	36										A	36483157	G	A	36483157	2	1	77	1	0	0	0	0	0	0	0	1	15302	1164	41	1		1	STK38	6	36483157	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2859544	36483157	134631910	137	23166										
TAF8	129685	broad.mit.edu	37	chr6	42019188	42019188	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgtgagctccttgctgacaGaggcagggtttgagagtgcc	15	8	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:42019188G>C	uc003ors.2	+	2	168	c.139G>C	c.(139-141)GAG>CAG	p.E47Q	CCND3_uc003orp.2_5'Flank|CCND3_uc011duk.1_5'Flank|CCND3_uc011dum.1_5'Flank|TAF8_uc003orr.2_Missense_Mutation_p.E47Q|TAF8_uc003ort.2_Missense_Mutation_p.E47Q|TAF8_uc003oru.1_Missense_Mutation_p.E47Q|TAF8_uc003orv.1_Missense_Mutation_p.E47Q|TAF8_uc011dun.1_5'UTR	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	47	Histone-fold.				cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			CTTGCTGACAGAGGCAGGGTT	0.537													0	0	0	0.002299	0	23	74										C	42019188	G	C	42019188	3	2	77	1	0	0	0	0	1	0	0	0	15531	943	33	1	145	1	TAF8	6	42019188	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5536031	42019188	129095879	138	23167										
CUL9	23113	broad.mit.edu	37	chr6	43156452	43156452	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tccgtcctgacagatcgctgAggttagcatactggggaggg	15	9	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:43156452A>C	uc003ouk.2	+	8	2254	c.2179A>C	c.(2179-2181)AGA>CGA	p.R727R	CUL9_uc003ouj.1_3'UTR|CUL9_uc003oul.2_Silent_p.R727R|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_3'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	727					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CAGATCGCTGAGGTTAGCATA	0.552													0	0	0	0.003214	0	34	67										C	43156452	A	C	43156452	2	2	77	1	0	0	0	0	0	0	0	1	4061	318	11	5		5	CUL9	6	43156452	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1137264	43156452	127958615	139	23168										
POLR1C	9533	broad.mit.edu	37	chr6	43488129	43488129	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctcagctgcggcctggccaaGaaattgacctgctcatgcac	10	14	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:43488129G>A	uc003ovn.2	+	6	676	c.619G>A	c.(619-621)GAA>AAA	p.E207K	POLR1C_uc003ovo.1_Missense_Mutation_p.E207K	NM_203290	NP_976035	O15160	RPAC1_HUMAN	RNA polymerase I subunit isoform 1	207					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCCTGGCCAAGAAATTGACCT	0.562													0	0	0	0.007291	0	22	107										A	43488129	G	A	43488129	3	1	77	1	0	0	0	0	1	0	0	0	12211	943	33	1	641	1	POLR1C	6	43488129	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	331677	43488129	127626938	140	23169										
POLH	5429	broad.mit.edu	37	chr6	43571701	43571701	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaatacatgggtgaactgacCcagttcactgaatcccagct	9	11	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:43571701C>T	uc003ovq.3	+	7	1141	c.837C>T	c.(835-837)ACC>ACT	p.T279T	POLH_uc010jyu.2_Silent_p.T155T|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Silent_p.T180T	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	279					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GTGAACTGACCCAGTTCACTG	0.408								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				0	0	0	0.007413	0	14	23										T	43571701	C	T	43571701	2	4	77	1	0	0	0	0	0	0	0	1	12202	610	22	2		2	POLH	6	43571701	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	83572	43571701	127543366	141	23170										
IBTK	25998	broad.mit.edu	37	chr6	82936933	82936933	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	catgtctgttcatctccatgTcctaatcgccctccaggacc	6	16	3	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:82936933T>G	uc003pjl.1	-	5	1157	c.630A>C	c.(628-630)GGA>GGC	p.G210G	IBTK_uc011dyv.1_Silent_p.G210G|IBTK_uc011dyw.1_Silent_p.G210G|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_Silent_p.G210G	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	210	RCC1 2.				negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CATCTCCATGTCCTAATCGCC	0.378													0	0	0	0.002445	0	26	47										G	82936933	T	G	82936933	2	3	77	1	0	0	0	0	0	0	0	1	7476	1654	58	5		5	IBTK	6	82936933	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	39365232	82936933	88178134	142	23171										
MDN1	23195	broad.mit.edu	37	chr6	90353822	90353822	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atctcgaagaatgatatagtAtgggaatgggaactcttcca	10	6	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:90353822A>G	uc003pnn.1	-	102	16809	c.16693T>C	c.(16693-16695)TAC>CAC	p.Y5565H		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5565	VWFA.				protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ATGATATAGTATGGGAATGGG	0.448													0	0	0	0.00245	0	12	46										G	90353822	A	G	90353822	3	3	77	1	0	0	0	0	1	0	0	0	9415	449	16	5	101	5	MDN1	6	90353822	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	7416889	90353822	80761245	143	23172										
MDN1	23195	broad.mit.edu	37	chr6	90422326	90422326	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctggttttcatgctcatcctGttgagacaatatactaagat	7	8	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:90422326G>A	uc003pnn.1	-	48	7514	c.7398C>T	c.(7396-7398)AAC>AAT	p.N2466N		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2466					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TGCTCATCCTGTTGAGACAAT	0.468													0	0	0	0.00361	0	41	52										A	90422326	G	A	90422326	2	1	77	1	0	0	0	0	0	0	0	1	9415	1368	48	2		2	MDN1	6	90422326	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	68504	90422326	80692741	144	23173										
MAP3K7	6885	broad.mit.edu	37	chr6	91254347	91254347	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggccccgtttaggcttggaAtaggctgcaaaaacacatat	10	9	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:91254347A>C	uc003pnz.1	-	12	1377	c.1215T>G	c.(1213-1215)TAT>TAG	p.Y405*	MAP3K7_uc003poa.1_Nonsense_Mutation_p.Y405*|MAP3K7_uc003pob.1_Intron|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	405					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TAGGCTTGGAATAGGCTGCAA	0.388													0	0	0	0.006214	0	9	34										C	91254347	A	C	91254347	4	2	77	1	0	0	0	0	0	1	0	0	9255	108	4	5	629	5	MAP3K7	6	91254347	Nonsense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	832021	91254347	79860720	145	23174										
MAP3K7	6885	broad.mit.edu	37	chr6	91296568	91296570	+	In_Frame_Del	DEL	GAG	GAG	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcatctcaccggccgaagacGaggaggaggaggaggcggca							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:91296568_91296570delGAG	uc003pnz.1	-	1	195_197	c.33_35delCTC	c.(31-36)TCCTCG>TCG	p.11_12SS>S	MAP3K7_uc003poa.1_In_Frame_Del_p.11_12SS>S|MAP3K7_uc003pob.1_In_Frame_Del_p.11_12SS>S|MAP3K7_uc003poc.1_In_Frame_Del_p.11_12SS>S	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	11_12	Poly-Ser.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GGCCGAAGACGAGGAGGAGGAGG	0.655																		9	99	---	---								-	91296570	GAG	-	91296568	7	5	77	1	0	1	0	1	0	0	0	0	9255	1059	37	0	1853	0	MAP3K7	6	91296568	In_Frame_Del	DEL	GAG	TCGA-FD-A3N5-01A-11D-A21A-08	42221	91296568	79818499	146	23175										
AIM1	202	broad.mit.edu	37	chr6	107011686	107011686	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtgggcagcctggtaacatcTggctccaagctaggcctggc	14	12	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:107011686T>G	uc003prh.2	+	19	5449	c.4962T>G	c.(4960-4962)TCT>TCG	p.S1654S	AIM1_uc003pri.2_Silent_p.S458S	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1654	Ricin B-type lectin.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TGGTAACATCTGGCTCCAAGC	0.493													0	0	0	0.002522	0	30	36										G	107011686	T	G	107011686	2	3	77	1	0	0	0	0	0	0	0	1	430	1567	55	5		5	AIM1	6	107011686	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	15715118	107011686	64103381	147	23176										
SMPD2	6610	broad.mit.edu	37	chr6	109765030	109765042	+	Frame_Shift_Del	DEL	GGCCCAGGATCTG	GGCCCAGGATCTG	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtgctaggaagggcaagggaGgcccaggatctgggcccaga							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:109765030_109765042delGGCCCAGGATCTG	uc003pti.2	+	10	1588_1600	c.1194_1206delGGCCCAGGATCTG	c.(1192-1206)GAGGCCCAGGATCTGfs	p.E398fs		NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	398_402					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		GGGCAAGGGAGGCCCAGGATCTGGGCCCAGAGC	0.568																		9	72	---	---								-	109765042	GGCCCAGGATCTG	-	109765030	7	5	77	1	0	1	0	1	0	0	0	0	14805	991	35	0	1232	0	SMPD2	6	109765030	Frame_Shift_Del	DEL	GGCCCAGGATCTG	TCGA-FD-A3N5-01A-11D-A21A-08	2753344	109765030	61350037	148	23177										
GRM1	2911	broad.mit.edu	37	chr6	146755399	146755401	+	In_Frame_Del	DEL	CAG	CAG	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agggcttgccccctcctctcCagcagcagcagcaaccccct							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:146755399_146755401delCAG	uc010khw.1	+	9	3522_3524	c.3052_3054delCAG	c.(3052-3054)CAGdel	p.Q1022del	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1022	Gln/Pro-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCTCCTCTCCAGCAGCAGCAGC	0.66																		11	471	---	---								-	146755401	CAG	-	146755399	7	5	77	1	0	1	0	1	0	0	0	0	6796	595	21	0	3147	0	GRM1	6	146755399	In_Frame_Del	DEL	CAG	TCGA-FD-A3N5-01A-11D-A21A-08	36990369	146755399	24359668	149	23178										
SASH1	23328	broad.mit.edu	37	chr6	148865308	148865308	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gacccaaagcaagagattttCtgaacctcagaaattgacaa	7	9	2	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:148865308C>A	uc003qme.1	+	18	3177	c.2702C>A	c.(2701-2703)TCT>TAT	p.S901Y	SASH1_uc011eeb.1_Missense_Mutation_p.S662Y|SASH1_uc003qmf.1_Missense_Mutation_p.S311Y	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	901							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		AAGAGATTTTCTGAACCTCAG	0.537													1	0	4.65686e-17	0.003755	5.10945e-17	30	102										A	148865308	C	A	148865308	3	1	77	1	0	0	0	0	1	0	0	0	13848	913	32	3	2772	3	SASH1	6	148865308	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2109909	148865308	22249759	150	23179										
CNKSR3	154043	broad.mit.edu	37	chr6	154762424	154762424	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtgaaaatgacatactactgAccttctggactgtagtggtc	10	8	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:154762424A>C	uc003qpy.2	-	4	1012	c.507_splice	c.e4+1	p.K169_splice		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3						negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CATACTACTGACCTTCTGGAC	0.373													0	0	0	0.001984	0	5	28										C	154762424	A	C	154762424	5	2	77	1	0	0	0	0	0	0	1	0	3608	289	10	5	1198	5	CNKSR3	6	154762424	Splice_Site	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5897116	154762424	16352643	151	23180										
EZR	7430	broad.mit.edu	37	chr6	159188477	159188477	+	Frame_Shift_Del	DEL	G	G	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acacggggggtggtgggggcGggggtgctgtcatcaccagg					rs139613796		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:159188477delG	uc003qrt.3	-	12	1627	c.1412delC	c.(1411-1413)CCGfs	p.P471fs	EZR_uc011efr.1_Frame_Shift_Del_p.P78fs|EZR_uc011efs.1_Frame_Shift_Del_p.P439fs|EZR_uc003qru.3_Frame_Shift_Del_p.P471fs	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	471	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TGGTGGGGGCGGGGGTGCTGT	0.597																		56	196	---	---								-	159188477	G	-	159188477	7	5	77	1	0	1	0	1	0	0	0	0	5335	1116	39	0	356	0	EZR	6	159188477	Frame_Shift_Del	DEL	G	TCGA-FD-A3N5-01A-11D-A21A-08	4426053	159188477	11926590	152	23181										
EIF2AK1	27102	broad.mit.edu	37	chr7	6086641	6086641	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	accttgtatactcttccgtaTccaccttttcctaagatggc	5	13	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:6086641T>C	uc003spp.2	-	5	677	c.531A>G	c.(529-531)GGA>GGG	p.G177G	EIF2AK1_uc003spq.2_Silent_p.G177G|EIF2AK1_uc011jwm.1_Silent_p.G53G|EIF2AK1_uc003spr.1_5'Flank	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	177	ATP (By similarity).|Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CTCTTCCGTATCCACCTTTTC	0.328													0	0	0	0.009718	0	33	15										C	6086641	T	C	6086641	2	2	77	1	0	0	0	0	0	0	0	1	4996	1422	50	5		5	EIF2AK1	7	6086641	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08		6086641	153052022	153	23182										
AGR2	10551	broad.mit.edu	37	chr7	16834567	16834567	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggtcacacttacacagagcTgtatctgcaggttcgtaagc	10	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:16834567T>C	uc003str.2	-	7	658	c.471A>G	c.(469-471)ACA>ACG	p.T157T		NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	157					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TACACAGAGCTGTATCTGCAG	0.378													0	0	0	0.004007	0	14	49										C	16834567	T	C	16834567	2	2	77	1	0	0	0	0	0	0	0	1	395	1567	55	5		5	AGR2	7	16834567	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	10747926	16834567	142304096	154	23183										
C7orf25	79020	broad.mit.edu	37	chr7	42949751	42949751	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgattaaagtagtaatgtccAgatttactcttttgcacaca	6	7	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:42949751A>T	uc003thw.2	-	2	1213	c.749T>A	c.(748-750)CTG>CAG	p.L250Q	C7orf25_uc010kxq.2_Missense_Mutation_p.L250Q|C7orf25_uc003thx.3_Missense_Mutation_p.L308Q|C7orf25_uc010kxr.2_Missense_Mutation_p.L308Q	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	250										skin(1)	1						AGTAATGTCCAGATTTACTCT	0.413													0	0	0	0.001882	0	18	51										T	42949751	A	T	42949751	3	4	77	1	0	0	0	0	1	0	0	0	2380	188	7	5	520	5	C7orf25	7	42949751	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	26115184	42949751	116188912	155	23184										
HECW1	23072	broad.mit.edu	37	chr7	43436489	43436489	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gatcagcttctctctctcagGtatgttttgctcacctgaga	8	11	5	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:43436489G>C	uc003tid.1	+	7	1236	c.631_splice	c.e7+1	p.D211_splice	HECW1_uc011kbi.1_Splice_Site_p.D211_splice|HECW1_uc003tie.1_Splice_Site_p.D243_splice	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TCTCTCTCAGGTATGTTTTGC	0.403													0	0	0	0.000978	0	10	31										C	43436489	G	C	43436489	5	2	77	1	0	0	0	0	0	0	1	0	7042	1275	44	4	650	4	HECW1	7	43436489	Splice_Site	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	486738	43436489	115702174	156	23185										
PKD1L1	168507	broad.mit.edu	37	chr7	47892757	47892757	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagcaggtatataaatctgcAcaattgactcatcccagaag	7	10	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:47892757A>G	uc003tny.1	-	31	4928	c.4928T>C	c.(4927-4929)GTG>GCG	p.V1643A		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1643	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ATAAATCTGCACAATTGACTC	0.388													0	0	0	0.005524	0	24	70										G	47892757	A	G	47892757	3	3	77	1	0	0	0	0	1	0	0	0	11964	159	6	5	3729	5	PKD1L1	7	47892757	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	4456268	47892757	111245906	157	23186										
GUSB	2990	broad.mit.edu	37	chr7	65439384	65439384	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccctacgcaccacttcttccAtcacctgcatgtggtgatgc	7	16	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:65439384A>C	uc003tun.2	-	8	1365	c.1289T>G	c.(1288-1290)ATG>AGG	p.M430R	GUSB_uc011kdt.1_Missense_Mutation_p.M284R	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	430					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						CACTTCTTCCATCACCTGCAT	0.607													0	0	0	0.00361	0	126	183										C	65439384	A	C	65439384	3	2	77	1	0	0	0	0	1	0	0	0	6902	217	8	5	686	5	GUSB	7	65439384	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	17546627	65439384	93699279	158	23187										
RHBDD2	57414	broad.mit.edu	37	chr7	75513098	75513100	+	In_Frame_Del	DEL	GAG	GAG	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	accttccccttcagcctgatGaggaggatatccgtgttcaa							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:75513098_75513100delGAG	uc003udw.1	+	3	753_755	c.669_671delGAG	c.(667-672)ATGAGG>ATG	p.R225del	RHBDD2_uc003udv.1_In_Frame_Del_p.R84del	NM_001040456	NP_001035546	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2 isoform a	225						integral to membrane	serine-type endopeptidase activity				0						TCAGCCTGATGAGGAGGATATCC	0.527																		68	176	---	---								-	75513100	GAG	-	75513098	7	5	77	1	0	1	0	1	0	0	0	0	13317	1290	45	0	679	0	RHBDD2	7	75513098	In_Frame_Del	DEL	GAG	TCGA-FD-A3N5-01A-11D-A21A-08	10073714	75513098	83625565	159	23188										
PION	54103	broad.mit.edu	37	chr7	77006665	77006665	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctgagcccaaacgaaatcctCagctattctgtctcttggga	8	12	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:77006665C>T	uc003ugf.2	-	9	698	c.619G>A	c.(619-621)GAG>AAG	p.E207K	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	207					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ACGAAATCCTCAGCTATTCTG	0.323													0	0	0	0.010504	0	17	88										T	77006665	C	T	77006665	3	4	77	1	0	0	0	0	1	0	0	0	11934	835	29	1	2037	1	PION	7	77006665	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1493567	77006665	82131998	160	23189										
ZKSCAN5	23660	broad.mit.edu	37	chr7	99129564	99129564	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acctcattcagcattacagaActcatacagcagagaagccc	6	13	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:99129564A>C	uc003uqv.2	+	7	2336	c.2212A>C	c.(2212-2214)ACT>CCT	p.T738P	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.T738P|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.T738P|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.T665P|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.T474P	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	738	C2H2-type 10.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCATTACAGAACTCATACAGC	0.398													0	0	0	0.003271	0	30	32										C	99129564	A	C	99129564	3	2	77	1	0	0	0	0	1	0	0	0	17687	43	2	5	2234	5	ZKSCAN5	7	99129564	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	22122899	99129564	60009099	161	23190										
CYP3A4	1576	broad.mit.edu	37	chr7	99375680	99375680	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tttccatactttttatgacaTtccatgtcaaacatacaaaa	2	9	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:99375680T>G	uc003urv.1	-	3	293	c.189A>C	c.(187-189)GAA>GAC	p.E63D	CYP3A4_uc003urw.1_Missense_Mutation_p.E63D|CYP3A4_uc011kiz.1_Missense_Mutation_p.E63D|CYP3A4_uc011kja.1_Intron|CYP3A4_uc011kjb.1_Intron	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	63					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTTTATGACATTCCATGTCAA	0.363													0	0	0	0.000978	0	11	18										G	99375680	T	G	99375680	3	3	77	1	0	0	0	0	1	0	0	0	4178	1490	52	5	1366	5	CYP3A4	7	99375680	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	246116	99375680	59762983	162	23191										
EPHB4	2050	broad.mit.edu	37	chr7	100417868	100417868	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtggctattggctgggcatgGctggcaggacccttctcctg	15	11	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:100417868G>C	uc003uwn.1	-	5	1350	c.859C>G	c.(859-861)CCA>GCA	p.P287A	EPHB4_uc003uwm.1_Missense_Mutation_p.P194A|EPHB4_uc010lhj.1_Missense_Mutation_p.P287A|EPHB4_uc011kkf.1_Missense_Mutation_p.P287A|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Missense_Mutation_p.P287A	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	287	Extracellular (Potential).|Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCTGGGCATGGCTGGCAGGAC	0.592													0	0	0	0.00361	0	164	335										C	100417868	G	C	100417868	3	2	77	1	0	0	0	0	1	0	0	0	5177	1203	42	4	2156	4	EPHB4	7	100417868	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1042188	100417868	58720795	163	23192										
COG5	10466	broad.mit.edu	37	chr7	106921779	106921779	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttacactgtataactggatgGtctttgccacattttttgac	7	8	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:106921779G>A	uc003ved.2	-	14	2159	c.1634C>T	c.(1633-1635)ACC>ATC	p.T545I	COG5_uc003vec.2_Missense_Mutation_p.T545I|COG5_uc003vee.2_Missense_Mutation_p.T545I	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	545					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TAACTGGATGGTCTTTGCCAC	0.299													0	0	0	0.010504	0	13	25										A	106921779	G	A	106921779	3	1	77	1	0	0	0	0	1	0	0	0	3661	1261	44	2	988	2	COG5	7	106921779	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	6503911	106921779	52216884	164	23193										
PPP1R3A	5506	broad.mit.edu	37	chr7	113519130	113519130	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgtcctttgatatgctctgTtatgtttgtcttattctctc	6	8	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:113519130T>G	uc010ljy.1	-	4	2048	c.2017A>C	c.(2017-2019)ACA>CCA	p.T673P		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	673					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATATGCTCTGTTATGTTTGTC	0.378													0	0	0	0.00361	0	43	49										G	113519130	T	G	113519130	3	3	77	1	0	0	0	0	1	0	0	0	12371	1725	60	5	1355	5	PPP1R3A	7	113519130	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	6597351	113519130	45619533	165	23194										
KCND2	3751	broad.mit.edu	37	chr7	120381638	120381638	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaaagcggaagcgcaaatgcTtacatgcagagcaaacggaa	11	8	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:120381638T>C	uc003vjj.1	+	3	2294	c.1329T>C	c.(1327-1329)GCT>GCC	p.A443A		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	443	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCGCAAATGCTTACATGCAGA	0.368													0	0	0	0.010504	0	14	24										C	120381638	T	C	120381638	2	2	77	1	0	0	0	0	0	0	0	1	8019	1596	56	5		5	KCND2	7	120381638	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	6862508	120381638	38757025	166	23195										
PLXNA4	91584	broad.mit.edu	37	chr7	131832748	131832748	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acactaatgccaccacggaaCcatctggcacctacagggaa	8	14	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:131832748C>G	uc003vra.3	-	27	5004	c.4775G>C	c.(4774-4776)GGT>GCT	p.G1592A	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1592	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CACCACGGAACCATCTGGCAC	0.507													0	0	0	0.001855	0	12	78										G	131832748	C	G	131832748	3	3	77	1	0	0	0	0	1	0	0	0	12122	507	18	4	933	4	PLXNA4	7	131832748	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	11451110	131832748	27305915	167	23196										
UBN2	254048	broad.mit.edu	37	chr7	138978726	138978726	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cacttacagcaagcatttcaCggtgagaacgccacctcctt	7	14	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:138978726C>A	uc011kqr.1	+	17	3993	c.3993C>A	c.(3991-3993)CAC>CAA	p.H1331Q		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1331										ovary(1)|skin(1)	2						AAGCATTTCACGGTGAGAACG	0.433													1	0	2.23348e-06	0.004007	2.31441e-06	14	25										A	138978726	C	A	138978726	3	1	77	1	0	0	0	0	1	0	0	0	16890	550	19	4	4059	4	UBN2	7	138978726	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	7145978	138978726	20159937	168	23197										
KEL	3792	broad.mit.edu	37	chr7	142650920	142650920	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctttagcagcatctcctccaCcagttgtgacatgtttttca	6	12	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:142650920C>A	uc003wcb.2	-	9	1258	c.1048G>T	c.(1048-1050)GTG>TTG	p.V350L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	350	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					ATCTCCTCCACCAGTTGTGAC	0.537													1	0	5.88774e-50	0.00361	6.8266e-50	109	199										A	142650920	C	A	142650920	3	1	77	1	0	0	0	0	1	0	0	0	8142	507	18	4	1194	4	KEL	7	142650920	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3672194	142650920	16487743	169	23198										
ZNF786	136051	broad.mit.edu	37	chr7	148769267	148769267	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggtgcattactaaatggttGttctcccaacagctttcccc	7	12	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:148769267G>A	uc003wfh.2	-	4	734	c.597C>T	c.(595-597)AAC>AAT	p.N199N	ZNF786_uc011kuk.1_Silent_p.N162N|ZNF786_uc003wfi.2_Silent_p.N113N	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	199	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTAAATGGTTGTTCTCCCAAC	0.582													0	0	0	0.00245	0	9	22										A	148769267	G	A	148769267	2	1	77	1	0	0	0	0	0	0	0	1	18155	1368	48	2		2	ZNF786	7	148769267	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	6118347	148769267	10369396	170	23199										
FAM86B1	85002	broad.mit.edu	37	chr8	12041205	12041205	+	Frame_Shift_Del	DEL	C	C	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcttccgcttcccatctgatCccatcccggcctggaaacaa							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:12041205delC	uc010lse.2	-	7	846	c.801delG	c.(799-801)GGGfs	p.G267fs	FAM66D_uc011kxp.1_Intron|FAM86B1_uc003wvf.3_RNA|FAM86B1_uc003wvi.3_Frame_Shift_Del_p.D121fs|FAM86B1_uc010lsd.2_RNA|FAM86B1_uc003wvh.3_Frame_Shift_Del_p.G110fs|FAM86B1_uc011kxq.1_Frame_Shift_Del_p.D121fs|FAM86B1_uc010lsf.2_Frame_Shift_Del_p.G110fs|FAM86B1_uc003wvj.3_Frame_Shift_Del_p.G201fs|FAM86B1_uc003wvk.3_Frame_Shift_Del_p.G301fs|FAM86B1_uc010lsg.2_RNA|FAM86B1_uc003wvl.3_RNA	NM_001083537	NP_001077006	Q8N7N1	F86B1_HUMAN	hypothetical protein LOC85002	267											0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		CCCATCTGATCCCATCCCGGC	0.552																		4	2	---	---								-	12041205	C	-	12041205	7	5	77	1	0	1	0	1	0	0	0	0	5644	842	30	0	93	0	FAM86B1	8	12041205	Frame_Shift_Del	DEL	C	TCGA-FD-A3N5-01A-11D-A21A-08		12041205	134322817	171	23200										
FGF20	26281	broad.mit.edu	37	chr8	16859521	16859521	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggccgcccagaaagcccccGacttcggctaagggagccat	12	15	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:16859521G>A	uc003wxc.1	-	1	154	c.21C>T	c.(19-21)GTC>GTT	p.V7V	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Silent_p.V7V	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	7					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GAAAGCCCCCGACTTCGGCTA	0.637													0	0	0	0.00308	0	6	3										A	16859521	G	A	16859521	2	1	77	1	0	0	0	0	0	0	0	1	5849	1045	37	1		1	FGF20	8	16859521	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4818316	16859521	129504501	172	23201										
DPYSL2	1808	broad.mit.edu	37	chr8	26509890	26509890	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atgtcaccgaaggctctggaCgctacattccccggaagccc	10	15	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:26509890C>T	uc003xfb.1	+	12	1749	c.1399C>T	c.(1399-1401)CGC>TGC	p.R467C	DPYSL2_uc003xfa.2_Missense_Mutation_p.R572C|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.R431C	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	467					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		AGGCTCTGGACGCTACATTCC	0.522													0	0	0	0.010504	0	19	45										T	26509890	C	T	26509890	3	4	77	1	0	0	0	0	1	0	0	0	4747	536	19	2	1445	2	DPYSL2	8	26509890	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	9650369	26509890	119854132	173	23202										
PRKDC	5591	broad.mit.edu	37	chr8	48817520	48817520	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctgcataactagtggctcaTacagttgccttgtcacctga	9	11	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:48817520T>C	uc003xqi.2	-	26	3008	c.2951A>G	c.(2950-2952)TAT>TGT	p.Y984C	PRKDC_uc003xqj.2_Missense_Mutation_p.Y984C|PRKDC_uc011ldh.1_Missense_Mutation_p.Y984C	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	984					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TAGTGGCTCATACAGTTGCCT	0.358								NHEJ					0	0	0	0.00333	0	19	19										C	48817520	T	C	48817520	3	2	77	1	0	0	0	0	1	0	0	0	12521	1406	49	5	9678	5	PRKDC	8	48817520	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	22307630	48817520	97546502	174	23203										
MOS	4342	broad.mit.edu	37	chr8	57025641	57025641	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cgagtcctcgaagacggcagCggagagggacgggcgcaggt	19	10	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:57025641C>T	uc011leb.1	-	1	901	c.901G>A	c.(901-903)GCT>ACT	p.A301T		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	301	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			AAGACGGCAGCGGAGAGGGAC	0.692													0	0	0	0.005524	0	26	67										T	57025641	C	T	57025641	3	4	77	1	0	0	0	0	1	0	0	0	9712	768	27	2	142	2	MOS	8	57025641	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	8208121	57025641	89338381	175	23204										
C8orf45	157777	broad.mit.edu	37	chr8	67803255	67803255	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taaaggtggtatctgctttaTaggagacttggcttcacaca	10	7	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:67803255T>C	uc003xwz.3	+	10	1400	c.1229T>C	c.(1228-1230)ATA>ACA	p.I410T	C8orf45_uc011lev.1_Missense_Mutation_p.I410T|C8orf45_uc011lew.1_Missense_Mutation_p.I341T|C8orf45_uc011lex.1_Missense_Mutation_p.I168T|C8orf45_uc003xwy.3_Missense_Mutation_p.I410T	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	410					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATCTGCTTTATAGGAGACTTG	0.368													0	0	0	0.002299	0	17	12										C	67803255	T	C	67803255	3	2	77	1	0	0	0	0	1	0	0	0	2430	1406	49	5	1263	5	C8orf45	8	67803255	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	10777614	67803255	78560767	176	23205										
RIMS2	9699	broad.mit.edu	37	chr8	105263981	105263981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agtagatccaaccttggcccCtctgacaagaagagcttccc	8	14	1	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:105263981C>T	uc003yls.2	+	28	4278	c.4037C>T	c.(4036-4038)CCT>CTT	p.P1346L	RIMS2_uc003ylp.2_Missense_Mutation_p.P1328L|RIMS2_uc003ylq.2_Missense_Mutation_p.P1142L|RIMS2_uc003ylr.2_Missense_Mutation_p.P1167L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1390					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCTTGGCCCCTCTGACAAGA	0.448										HNSCC(12;0.0054)			0	0	0	0.006214	0	7	64										T	105263981	C	T	105263981	3	4	77	1	0	0	0	0	1	0	0	0	13368	681	24	2	4273	2	RIMS2	8	105263981	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	37460726	105263981	41100041	177	23206										
CSMD3	114788	broad.mit.edu	37	chr8	114290867	114290867	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcactaactgcaaaatcactGgtcaaacgtagtgagaacac	8	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:114290867G>C	uc003ynu.2	-	3	627	c.468C>G	c.(466-468)ACC>ACG	p.T156T	CSMD3_uc003ynt.2_Silent_p.T116T|CSMD3_uc011lhx.1_Silent_p.T156T|CSMD3_uc010mcx.1_Silent_p.T156T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	156	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAAAATCACTGGTCAAACGTA	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004007	0	11	41										C	114290867	G	C	114290867	2	2	77	1	0	0	0	0	0	0	0	1	3946	1335	47	4		4	CSMD3	8	114290867	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	9026886	114290867	32073155	178	23207										
ANXA13	312	broad.mit.edu	37	chr8	124714886	124714886	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccacccctggaatcaccttgCcgtacgttgccttgtacttt	7	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:124714886C>A	uc003yqu.2	-	3	255	c.182G>T	c.(181-183)GGC>GTC	p.G61V	ANXA13_uc003yqt.2_Missense_Mutation_p.G102V	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a	61	Annexin 1.				cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			AATCACCTTGCCGTACGTTGC	0.507													1	0	1.26612e-14	0.003271	1.3821e-14	26	102										A	124714886	C	A	124714886	3	1	77	1	0	0	0	0	1	0	0	0	717	739	26	4	804	4	ANXA13	8	124714886	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	10424019	124714886	21649136	179	23208										
JRK	8629	broad.mit.edu	37	chr8	143745928	143745928	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cggaacacggcacgcagcgcCcgcagctgccccacttcctg	11	19	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:143745928C>T	uc003ywo.2	-	3	2062	c.1548G>A	c.(1546-1548)CGG>CGA	p.R516R	JRK_uc003ywp.2_Silent_p.R516R|JRK_uc010mew.1_Missense_Mutation_p.G517E	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				CACGCAGCGCCCgcagctgcc	0.363													0	0	0	0.007413	0	15	27										T	143745928	C	T	143745928	2	4	77	1	0	0	0	0	0	0	0	1	7964	623	22	2		2	JRK	8	143745928	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	19031042	143745928	2618094	180	23209										
FBXL6	26233	broad.mit.edu	37	chr8	145579794	145579794	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagtgtatggcaccacttctGggtcaaaaaggggctgccct	12	11	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:145579794G>T	uc003zcb.2	-	8	1331	c.1306C>A	c.(1306-1308)CAG>AAG	p.Q436K	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.Q163K|FBXL6_uc003zca.2_Missense_Mutation_p.Q430K|FBXL6_uc010mfx.2_Missense_Mutation_p.Q197K|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	436	LRR 9.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CACCACTTCTGGGTCAAAAAG	0.592													1	0	1.53134e-21	0.00361	1.70193e-21	58	105										T	145579794	G	T	145579794	3	4	77	1	0	0	0	0	1	0	0	0	5723	1357	47	4	321	4	FBXL6	8	145579794	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1833866	145579794	784228	181	23210										
INSL4	3641	broad.mit.edu	37	chr9	5231528	5231528	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agagttcaggtccaggatggCcagcctgttccggtcctatc	12	12	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:5231528C>T	uc003ziy.2	+	1	110	c.5C>T	c.(4-6)GCC>GTC	p.A2V		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	2					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		TCCAGGATGGCCAGCCTGTTC	0.557													0	0	0	0.005524	0	28	31										T	5231528	C	T	5231528	3	4	77	1	0	0	0	0	1	0	0	0	7768	739	26	2	7	2	INSL4	9	5231528	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		5231528	135981903	182	23211										
CNTFR	1271	broad.mit.edu	37	chr9	34557969	34557969	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gagcggcagctgagcacaggCtcccgcggcggcactggggg	19	13	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:34557969C>A	uc003zup.1	-	5	614	c.333G>T	c.(331-333)GAG>GAT	p.E111D	CNTFR_uc003zuq.1_Missense_Mutation_p.E111D	NM_147164	NP_671693	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	111	Fibronectin type-III 1.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			ovary(3)|central_nervous_system(1)|skin(1)	5	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		TGAGCACAGGCTCCCGCGGCG	0.627													1	0	2.97109e-61	0.00361	3.46359e-61	132	252										A	34557969	C	A	34557969	3	1	77	1	0	0	0	0	1	0	0	0	3638	796	28	4	809	4	CNTFR	9	34557969	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	29326441	34557969	106655462	183	23212										
FOXB2	442425	broad.mit.edu	37	chr9	79635344	79635344	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccgccgccgctgccgccgcGgccgcggcgtccacgtcagg	16	20	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:79635344G>A	uc004ako.1	+	1	774	c.774G>A	c.(772-774)GCG>GCA	p.A258A		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	258	Poly-Ala.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						ctgccgccgcggccgcGGCGT	0.453													0	0	0	0.00499	0	16	20										A	79635344	G	A	79635344	2	1	77	1	0	0	0	0	0	0	0	1	5993	1103	39	2		2	FOXB2	9	79635344	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	45077375	79635344	61578087	184	23213										
SYK	6850	broad.mit.edu	37	chr9	93629433	93629433	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acttggtcagcgggtggaatAatctcaagaatcaaatcata	9	7	4	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:93629433A>G	uc004aqz.2	+	7	1072	c.867A>G	c.(865-867)ATA>ATG	p.I289M	SYK_uc004aqy.2_Missense_Mutation_p.I289M|SYK_uc004ara.2_Intron|SYK_uc004arb.2_Intron|SYK_uc004arc.2_Missense_Mutation_p.I289M|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	289	Linker.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						CGGGTGGAATAATCTCAAGAA	0.463			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								0	0	0	0.006999	0	33	38										G	93629433	A	G	93629433	3	3	77	1	0	0	0	0	1	0	0	0	15435	352	13	5	889	5	SYK	9	93629433	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	13994089	93629433	47583998	185	23214										
WNK2	65268	broad.mit.edu	37	chr9	96051184	96051184	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcctggggcacccccagcccCtttggccccctcctcccctc	7	24	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:96051184C>G	uc004ati.1	+	20	4259	c.4259C>G	c.(4258-4260)CCT>CGT	p.P1420R	WNK2_uc011lud.1_Missense_Mutation_p.P1383R|WNK2_uc004atj.2_Missense_Mutation_p.P1383R|WNK2_uc004atk.2_Missense_Mutation_p.P1020R|WNK2_uc004atl.1_5'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1420					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CCCCCAGCCCCTTTGGCCCCC	0.652													0	0	0	0.002299	0	20	13										G	96051184	C	G	96051184	3	3	77	1	0	0	0	0	1	0	0	0	17375	681	24	4	4222	4	WNK2	9	96051184	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2421751	96051184	45162247	186	23215										
GRIN3A	116443	broad.mit.edu	37	chr9	104499615	104499615	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgctgatcactggaatgtgcAggactaagctgaccaagtcg	12	9	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:104499615A>G	uc004bbp.1	-	1	1248	c.647T>C	c.(646-648)CTG>CCG	p.L216P	GRIN3A_uc004bbq.1_Missense_Mutation_p.L216P	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	216	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGGAATGTGCAGGACTAAGCT	0.627													0	0	0	0.00361	0	38	110										G	104499615	A	G	104499615	3	3	77	1	0	0	0	0	1	0	0	0	6783	188	7	5	2736	5	GRIN3A	9	104499615	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	8448431	104499615	36713816	187	23216										
ABCA1	19	broad.mit.edu	37	chr9	107593948	107593948	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccacattgtcaatgtccattCggatcttgtacttgacatga	7	10	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:107593948C>T	uc004bcl.2	-	13	1983	c.1670G>A	c.(1669-1671)CGA>CAA	p.R557Q		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	557	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATGTCCATTCGGATCTTGTA	0.488													0	0	0	0.001855	0	13	14										T	107593948	C	T	107593948	3	4	77	1	0	0	0	0	1	0	0	0	28	884	31	1	5267	1	ABCA1	9	107593948	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3094333	107593948	33619483	188	23217										
ZNF462	58499	broad.mit.edu	37	chr9	109694734	109694734	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gatgtccatgcaggggctgcGttctcatgagaggagccacc	14	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:109694734G>T	uc004bcz.2	+	5	6309	c.6020G>T	c.(6019-6021)CGT>CTT	p.R2007L	ZNF462_uc010mto.2_Missense_Mutation_p.R1916L|ZNF462_uc004bda.2_Missense_Mutation_p.R1915L|ZNF462_uc011lvz.1_5'Flank	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2007					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CAGGGGCTGCGTTCTCATGAG	0.537													1	0	6.44725e-10	0.002299	6.79575e-10	20	59										T	109694734	G	T	109694734	3	4	77	1	0	0	0	0	1	0	0	0	17923	1145	40	4	6034	4	ZNF462	9	109694734	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2100786	109694734	31518697	189	23218										
C9orf152	401546	broad.mit.edu	37	chr9	112963549	112963549	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgatgtacttgatgactggtGtcctggggggaggtttggac	17	5	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:112963549G>T	uc011lwk.1	-	2	953	c.399C>A	c.(397-399)GAC>GAA	p.D133E		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	133											0						GATGACTGGTGTCCTGGGGGG	0.557													1	0	2.51541e-25	0.004878	2.8249e-25	31	129										T	112963549	G	T	112963549	3	4	77	1	0	0	0	0	1	0	0	0	2463	1368	48	4	324	4	C9orf152	9	112963549	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3268815	112963549	28249882	190	23219										
SLC46A2	57864	broad.mit.edu	37	chr9	115652137	115652137	+	Frame_Shift_Del	DEL	T	T	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtggttttatggggttttgcTtttccaggagatggagggtg							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:115652137delT	uc004bgk.2	-	1	1057	c.825delA	c.(823-825)AAAfs	p.K275fs		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	275	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						GGGGTTTTGCTTTTCCAGGAG	0.537																		36	84	---	---								-	115652137	T	-	115652137	7	5	77	1	0	1	0	1	0	0	0	0	14645	1606	56	0	618	0	SLC46A2	9	115652137	Frame_Shift_Del	DEL	T	TCGA-FD-A3N5-01A-11D-A21A-08	2688588	115652137	25561294	191	23220										
TNC	3371	broad.mit.edu	37	chr9	117846585	117846585	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccaggctccagctcctggatGatggtggacgtctggtcccc	13	14	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:117846585G>T	uc004bjj.3	-	4	2396	c.2034C>A	c.(2032-2034)ATC>ATA	p.I678I	TNC_uc010mvf.2_Silent_p.I678I	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	678	Fibronectin type-III 1.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GCTCCTGGATGATGGTGGACG	0.572													1	0	3.41278e-10	0.00499	3.62397e-10	14	43										T	117846585	G	T	117846585	2	4	77	1	0	0	0	0	0	0	0	1	16267	1280	45	3		3	TNC	9	117846585	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2194448	117846585	23366846	192	23221										
MEGF9	1955	broad.mit.edu	37	chr9	123421791	123421791	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggccgacactcacactgccCtgtggtctggttgcagcgat	12	13	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:123421791C>T	uc004bkj.1	-	4	775	c.775G>A	c.(775-777)GGG>AGG	p.G259R	MEGF9_uc011lyb.1_Missense_Mutation_p.G214R|MEGF9_uc004bkk.3_Missense_Mutation_p.G214R	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	222	Laminin EGF-like 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						TCACACTGCCCTGTGGTCTGG	0.478													0	0	0	0.006214	0	8	11										T	123421791	C	T	123421791	3	4	77	1	0	0	0	0	1	0	0	0	9464	681	24	2	1164	2	MEGF9	9	123421791	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5575206	123421791	17791640	193	23222										
FAM129B	64855	broad.mit.edu	37	chr9	130280165	130280165	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agctccttggactgtcggtaCatgcggatggcatctgtgaa	13	9	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:130280165C>T	uc004brh.2	-	6	847	c.645G>A	c.(643-645)ATG>ATA	p.M215I	FAM129B_uc004bri.2_Missense_Mutation_p.M202I|FAM129B_uc004brj.3_Missense_Mutation_p.M215I	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	215							protein binding				0						ACTGTCGGTACATGCGGATGG	0.612													0	0	0	0.005443	0	21	30										T	130280165	C	T	130280165	3	4	77	1	0	0	0	0	1	0	0	0	5437	478	17	2	1631	2	FAM129B	9	130280165	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	6858374	130280165	10933266	194	23223										
CLIC3	9022	broad.mit.edu	37	chr9	139890163	139890163	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggagcaggaccatgaagagcCgctggcaggaggggcagtga	19	8	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:139890163C>G	uc004ckj.1	-	2	109	c.80G>C	c.(79-81)CGG>CCG	p.R27P		NM_004669	NP_004660	O95833	CLIC3_HUMAN	chloride intracellular channel 3	27	Required for insertion into the membrane (By similarity).|Helical; (Potential).|GST N-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	protein binding|voltage-gated chloride channel activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CATGAAGAGCCGCTGGCAGGA	0.697													0	0	0	0.00245	0	11	31										G	139890163	C	G	139890163	3	3	77	1	0	0	0	0	1	0	0	0	3527	652	23	4	650	4	CLIC3	9	139890163	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	9609998	139890163	1323268	195	23224										
GRIN1	2902	broad.mit.edu	37	chr9	140052946	140052946	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acctgcagaaccgcaagctgGtgcaagtgggcatctacaat	11	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:140052946G>T	uc004clk.2	+	7	1414	c.1084G>T	c.(1084-1086)GTG>TTG	p.V362L	GRIN1_uc004cli.1_Missense_Mutation_p.V37L|GRIN1_uc004clj.1_Missense_Mutation_p.V359L|GRIN1_uc004cll.2_Missense_Mutation_p.V362L|GRIN1_uc004clm.2_Missense_Mutation_p.V362L|GRIN1_uc004cln.2_Missense_Mutation_p.V380L|GRIN1_uc004clo.2_Missense_Mutation_p.V380L	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	362	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCGCAAGCTGGTGCAAGTGGG	0.617													1	0	1.16021e-09	0.007291	1.21992e-09	25	80										T	140052946	G	T	140052946	3	4	77	1	0	0	0	0	1	0	0	0	6778	1261	44	4	1177	4	GRIN1	9	140052946	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	162783	140052946	1160485	196	23225										
SSNA1	8636	broad.mit.edu	37	chr9	140083594	140083594	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaggacgagaagcagcggctGcagaatgaggtgaggcagct	18	7	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:140083594G>A	uc004cls.2	+	2	254	c.129G>A	c.(127-129)CTG>CTA	p.L43L	ANAPC2_uc004clq.1_5'Flank|ANAPC2_uc004clr.1_5'Flank|ANAPC2_uc011mer.1_5'Flank	NM_003731	NP_003722	O43805	SSNA1_HUMAN	nuclear autoantigen of 14 kDa	43	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus				breast(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.43e-05)|Epithelial(140;0.00087)		AGCAGCGGCTGCAGAATGAGG	0.657													0	0	0	0.00333	0	23	30										A	140083594	G	A	140083594	2	1	77	1	0	0	0	0	0	0	0	1	15186	1306	46	2		2	SSNA1	9	140083594	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	30648	140083594	1129837	197	23226										
ARRDC1	92714	broad.mit.edu	37	chr9	140508609	140508609	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	caggcactgcagctgcatgcCgacgttgagaaccagtcagg	13	12	1	1	rs145510266		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:140508609C>G	uc004cns.2	+	5	635	c.561C>G	c.(559-561)GCC>GCG	p.A187A	ARRDC1_uc004cnt.2_Silent_p.A62A|ARRDC1_uc004cnu.2_RNA|ARRDC1_uc004cnv.2_Silent_p.A167A|ARRDC1_uc004cnw.2_Silent_p.A62A|ARRDC1_uc004cnp.1_Silent_p.A187A|ARRDC1_uc004cnq.1_Silent_p.A169A|ARRDC1_uc011mfb.1_Silent_p.A62A|ARRDC1_uc004cnx.1_Silent_p.A62A|ARRDC1_uc004cny.2_RNA	NM_152285	NP_689498	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	187											0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		AGCTGCATGCCGACGTTGAGA	0.642													0	0	0	0.00361	0	340	356										G	140508609	C	G	140508609	2	3	77	1	0	0	0	0	0	0	0	1	982	639	23	4		4	ARRDC1	9	140508609	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	425015	140508609	704822	198	23227										
PFKP	5214	broad.mit.edu	37	chr10	3162099	3162099	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gacaggcctacctgggactcCtggagctgtcagccgcccgg	14	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:3162099C>T	uc001igp.2	+	16	1582	c.1546C>T	c.(1546-1548)CTG>TTG	p.L516L	PFKP_uc001igq.2_Silent_p.L508L|PFKP_uc009xhr.2_Silent_p.L478L|PFKP_uc009xhs.1_Silent_p.L300L|PFKP_uc009xht.2_Silent_p.L254L|PFKP_uc009xhu.2_Silent_p.L22L	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	516					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CCTGGGACTCCTGGAGCTGTC	0.632											OREG0019976	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	72	175										T	3162099	C	T	3162099	2	4	77	1	0	0	0	0	0	0	0	1	11766	680	24	2		2	PFKP	10	3162099	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		3162099	132372648	199	23228										
ITIH5	80760	broad.mit.edu	37	chr10	7621948	7621948	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagacgatgagggacacgctCcggtctccaatgccactgtg	12	12	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:7621948C>A	uc001ijq.2	-	9	1267	c.1188G>T	c.(1186-1188)CGG>CGT	p.R396R	ITIH5_uc001ijp.2_Silent_p.R182R|ITIH5_uc001ijr.1_Silent_p.R396R	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	396	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GGGACACGCTCCGGTCTCCAA	0.632													1	0	8.20599e-20	0.002852	9.07311e-20	44	38										A	7621948	C	A	7621948	2	1	77	1	0	0	0	0	0	0	0	1	7907	842	30	3		3	ITIH5	10	7621948	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	4459849	7621948	127912799	200	23229										
PRPF18	8559	broad.mit.edu	37	chr10	13655788	13655788	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgaatgccagagaagattaTgtgaaacgcagtgtgcaggg	14	5	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:13655788T>C	uc001imp.2	+	7	775	c.627T>C	c.(625-627)TAT>TAC	p.Y209Y	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	209					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						GAGAAGATTATGTGAAACGCA	0.453													0	0	0	0.000978	0	10	41										C	13655788	T	C	13655788	2	2	77	1	0	0	0	0	0	0	0	1	12563	1471	51	5		5	PRPF18	10	13655788	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	6033840	13655788	121878959	201	23230										
ZNF485	220992	broad.mit.edu	37	chr10	44112556	44112556	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agtggaaataaaccgtatcaGtgtcgtgactgtgggaaggc	14	6	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:44112556G>A	uc010qfc.1	+	5	1259	c.1065G>A	c.(1063-1065)CAG>CAA	p.Q355Q	ZNF485_uc010qfd.1_Silent_p.Q264Q	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	355	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AACCGTATCAGTGTCGTGACT	0.428													0	0	0	0.008871	0	17	69										A	44112556	G	A	44112556	2	1	77	1	0	0	0	0	0	0	0	1	17935	1020	36	2		2	ZNF485	10	44112556	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	30456768	44112556	91422191	202	23231										
SYT15	83849	broad.mit.edu	37	chr10	46969378	46969378	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggcacagaaccttctccacAgacagcagcttgccccgatc	8	16	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:46969378A>G	uc001jea.2	-	2	236	c.83T>C	c.(82-84)CTG>CCG	p.L28P	SYT15_uc001jdz.2_Missense_Mutation_p.L28P|SYT15_uc001jeb.2_Intron|SYT15_uc010qfp.1_5'Flank	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	28	Helical; Signal-anchor for type III membrane protein; (Potential).					integral to membrane|plasma membrane					0						CCTTCTCCACAGACAGCAGCT	0.652													0	0	0	0.00361	0	55	162										G	46969378	A	G	46969378	3	3	77	1	0	0	0	0	1	0	0	0	15468	188	7	5	1264	5	SYT15	10	46969378	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	2856822	46969378	88565369	203	23232										
NRBF2	29982	broad.mit.edu	37	chr10	64911926	64911926	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acagcatatctttctgaagcCatgaagctgacacagtcaga	8	10	3	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:64911926C>G	uc001jmj.3	+	3	356	c.132C>G	c.(130-132)GCC>GCG	p.A44A	NRBF2_uc010qip.1_Silent_p.A34A	NM_030759	NP_110386	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	44					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding				0	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTCTGAAGCCATGAAGCTGA	0.353													0	0	0	0.008291	0	8	43										G	64911926	C	G	64911926	2	3	77	1	0	0	0	0	0	0	0	1	10641	581	21	4		4	NRBF2	10	64911926	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	17942548	64911926	70622821	204	23233										
CDH23	64072	broad.mit.edu	37	chr10	73574769	73574769	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcccagggcagggtagcctgCgcttccgccacaagccacca	12	17	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:73574769C>T	uc001jrx.3	+	68	10176	c.9799C>T	c.(9799-9801)CGC>TGC	p.R3267C	CDH23_uc001jsg.3_Missense_Mutation_p.R1027C|CDH23_uc001jsh.3_Missense_Mutation_p.R992C|CDH23_uc001jsi.3_Missense_Mutation_p.R992C|CDH23_uc001jsj.3_Missense_Mutation_p.R164C|CDH23_uc010qjr.1_Missense_Mutation_p.R129C	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3267	Cytoplasmic (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGGTAGCCTGCGCTTCCGCCA	0.667													0	0	0	0.006122	0	15	86										T	73574769	C	T	73574769	3	4	77	1	0	0	0	0	1	0	0	0	3108	768	27	2	10493	2	CDH23	10	73574769	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	8662843	73574769	61959978	205	23234										
CAMK2G	818	broad.mit.edu	37	chr10	75634270	75634270	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cccgcgccgacgtcggtgcaCagtcaccgccgcccggccga	13	20	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:75634270C>T	uc001jvv.1	-	1	74	c.-50G>A	c.(-52--48)CTGTG>CTATG		CAMK2G_uc001jvm.1_Translation_Start_Site|CAMK2G_uc001jvo.1_Translation_Start_Site|CAMK2G_uc001jvq.1_Translation_Start_Site|CAMK2G_uc001jvr.1_Translation_Start_Site|CAMK2G_uc001jvp.1_Translation_Start_Site|CAMK2G_uc001jvs.1_Translation_Start_Site|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Translation_Start_Site|CAMK2G_uc010qkv.1_Translation_Start_Site	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II						insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CGTCGGTGCACAGTCACCGCC	0.721													0	0	0	0.000978	0	8	27										T	75634270	C	T	75634270	1	4	77	1	0	0	0	0	0	0	0	0	2602	493	17	2		2	CAMK2G	10	75634270	Translation_Start_Site	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2059501	75634270	59900477	206	23235										
IFIT2	3433	broad.mit.edu	37	chr10	91065822	91065822	+	Frame_Shift_Del	DEL	A	A	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccttggatgattttgaagacAaagtattttaccggactgag							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:91065822delA	uc009xts.2	+	2	284	c.109delA	c.(109-111)AAAfs	p.K37fs	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	37					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				TTTTGAAGACAAAGTATTTTA	0.438																		22	13	---	---								-	91065822	A	-	91065822	7	5	77	1	0	1	0	1	0	0	0	0	7523	131	5	0	115	0	IFIT2	10	91065822	Frame_Shift_Del	DEL	A	TCGA-FD-A3N5-01A-11D-A21A-08	15431552	91065822	44468925	207	23236										
PLCE1	51196	broad.mit.edu	37	chr10	96025625	96025625	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	attaaagaactgcagctaccCctctcatactattacatcga	4	12	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:96025625C>T	uc001kjk.2	+	16	4825	c.4191C>T	c.(4189-4191)CCC>CCT	p.P1397P	PLCE1_uc010qnx.1_Silent_p.P1381P|PLCE1_uc001kjm.2_Silent_p.P1089P	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1397	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TGCAGCTACCCCTCTCATACT	0.413													0	0	0	0.007413	0	18	4										T	96025625	C	T	96025625	2	4	77	1	0	0	0	0	0	0	0	1	12034	610	22	2		2	PLCE1	10	96025625	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	4959803	96025625	39509122	208	23237										
PDZD8	118987	broad.mit.edu	37	chr10	119044045	119044045	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccacatcttcaagttttaaActaacatgccccaaacagat	4	12	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:119044045A>T	uc001lde.1	-	5	2398	c.2199T>A	c.(2197-2199)AGT>AGA	p.S733R		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	733					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CAAGTTTTAAACTAACATGCC	0.438													0	0	0	0.00245	0	12	4										T	119044045	A	T	119044045	3	4	77	1	0	0	0	0	1	0	0	0	11705	40	2	5	1269	5	PDZD8	10	119044045	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	23018420	119044045	16490702	209	23238										
MKI67	4288	broad.mit.edu	37	chr10	129903242	129903242	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcctggcaggtccaatttctGcactggagttcccataaatg	9	11	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:129903242G>A	uc001lke.2	-	13	7057	c.6862C>T	c.(6862-6864)CAG>TAG	p.Q2288*	MKI67_uc001lkf.2_Nonsense_Mutation_p.Q1928*|MKI67_uc009yav.1_Nonsense_Mutation_p.Q1863*|MKI67_uc009yaw.1_Nonsense_Mutation_p.Q1438*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2288	16 X 122 AA approximate repeats.|11.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCAATTTCTGCACTGGAGTT	0.483													0	0	0	0.00361	0	45	20										A	129903242	G	A	129903242	4	1	77	1	0	0	0	0	0	1	0	0	9598	1328	46	2	2920	2	MKI67	10	129903242	Nonsense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	10859197	129903242	5631505	210	23239										
GPR123	84435	broad.mit.edu	37	chr10	134912182	134912182	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	caagggccggcacacgctccTgaatttctgcttccacgcgg	11	15	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:134912182T>A	uc001llx.3	+	4	606	c.170T>A	c.(169-171)CTG>CAG	p.L57Q	GPR123_uc001llw.2_Missense_Mutation_p.L777Q	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	57	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CACACGCTCCTGAATTTCTGC	0.652													0	0	0	0.00361	0	88	45										A	134912182	T	A	134912182	3	1	77	1	0	0	0	0	1	0	0	0	6637	1580	55	5	180	5	GPR123	10	134912182	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	5008940	134912182	622565	211	23240										
NLRP6	171389	broad.mit.edu	37	chr11	285201	285201	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctgagcgagcagtcactacAggagcttcaggctgtgaaga	14	9	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:285201A>G	uc010qvs.1	+	8	2576	c.2576A>G	c.(2575-2577)CAG>CGG	p.Q859R	NLRP6_uc010qvt.1_Missense_Mutation_p.Q858R	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	859	LRR 5.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CAGTCACTACAGGAGCTTCAG	0.622													0	0	0	0.006214	0	7	14										G	285201	A	G	285201	3	3	77	1	0	0	0	0	1	0	0	0	10481	188	7	5	2606	5	NLRP6	11	285201	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08		285201	134721315	212	23241										
CARS	833	broad.mit.edu	37	chr11	3026647	3026647	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtgtttctgtctaccagtttCaccactgtgggcagtcctgc	10	12	3	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:3026647C>T	uc001lxh.2	-	19	1991	c.1917G>A	c.(1915-1917)GTG>GTA	p.V639V	CARS_uc009ydu.2_RNA|CARS_uc001lxe.2_Silent_p.V629V|CARS_uc001lxf.2_Silent_p.V722V|CARS_uc001lxg.2_Silent_p.V639V|CARS_uc010qxo.1_Silent_p.V722V|CARS_uc010qxp.1_Silent_p.V652V	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	639					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	CTACCAGTTTCACCACTGTGG	0.408			T	ALK	ALCL								0	0	0	0.003755	0	30	39										T	3026647	C	T	3026647	2	4	77	1	0	0	0	0	0	0	0	1	2657	813	29	1		1	CARS	11	3026647	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	2741446	3026647	131979869	213	23242										
OR52N5	390075	broad.mit.edu	37	chr11	5799737	5799737	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tccccacaaggaagatgatgTacattgtgcagagtgggagg	14	7	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:5799737T>A	uc010qzn.1	-	1	128	c.128A>T	c.(127-129)TAC>TTC	p.Y43F	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GAAGATGATGTACATTGTGCA	0.408													0	0	0	0.00361	0	44	36										A	5799737	T	A	5799737	3	1	77	1	0	0	0	0	1	0	0	0	11130	1638	57	5	850	5	OR52N5	11	5799737	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2773090	5799737	129206779	214	23243										
RRP8	23378	broad.mit.edu	37	chr11	6621449	6621449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgggccctaccagagggggcCcagtcttttggaaatcaaac	12	11	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:6621449C>T	uc001med.2	-	7	1377	c.1298G>A	c.(1297-1299)GGG>GAG	p.G433E		NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	433					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						CAGAGGGGGCCCAGTCTTTTG	0.522													0	0	0	0.007291	0	24	21										T	6621449	C	T	6621449	3	4	77	1	0	0	0	0	1	0	0	0	13690	623	22	2	76	2	RRP8	11	6621449	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	821712	6621449	128385067	215	23244										
DCHS1	8642	broad.mit.edu	37	chr11	6652344	6652344	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccttggtcatgagcactcagTgtcagcacatagtggggccg	13	11	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:6652344T>A	uc001mem.1	-	9	4280	c.3870A>T	c.(3868-3870)ACA>ACT	p.T1290T		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1290	Cadherin 12.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCACTCAGTGTCAGCACAT	0.622													0	0	0	0.004007	0	13	21										A	6652344	T	A	6652344	2	1	77	1	0	0	0	0	0	0	0	1	4287	1683	59	5		5	DCHS1	11	6652344	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	30895	6652344	128354172	216	23245										
E2F8	79733	broad.mit.edu	37	chr11	19253864	19253864	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctgtaacatgaactttcttgAtaagatccaggctactcaga	7	9	2	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:19253864A>G	uc001mpm.2	-	7	1505	c.983T>C	c.(982-984)ATC>ACC	p.I328T	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.I328T	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	328	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						AACTTTCTTGATAAGATCCAG	0.358													0	0	0	0.003755	0	31	21										G	19253864	A	G	19253864	3	3	77	1	0	0	0	0	1	0	0	0	4873	333	12	5	1648	5	E2F8	11	19253864	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	12601520	19253864	115752652	217	23246										
CRY2	1408	broad.mit.edu	37	chr11	45891186	45891186	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	accccatctgcatccagatcCcctgggaccgcaatcctgag	8	17	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:45891186C>T	uc010rgn.1	+	7	1097	c.1075C>T	c.(1075-1077)CCC>TCC	p.P359S	CRY2_uc009ykw.2_Missense_Mutation_p.P277S|CRY2_uc010rgo.1_Missense_Mutation_p.P81S	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	338	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						CATCCAGATCCCCTGGGACCG	0.587													0	0	0	0.00361	0	43	161										T	45891186	C	T	45891186	3	4	77	1	0	0	0	0	1	0	0	0	3904	623	22	2	1137	2	CRY2	11	45891186	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	26637322	45891186	89115330	218	23247										
OR4A16	81327	broad.mit.edu	37	chr11	55111294	55111294	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aatggtggaataatttgtatGgtcatctttacctttctgct	8	6	3	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:55111294G>A	uc010rie.1	+	1	618	c.618G>A	c.(616-618)ATG>ATA	p.M206I		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TAATTTGTATGGTCATCTTTA	0.438													0	0	0	0.00245	0	15	86										A	55111294	G	A	55111294	3	1	77	1	0	0	0	0	1	0	0	0	11041	1348	47	2	620	2	OR4A16	11	55111294	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	9220108	55111294	79895222	219	23248										
HRASLS5	117245	broad.mit.edu	37	chr11	63233662	63233662	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aatcaggctgtactgcacgaTcttgttgaccatcttttttg	8	9	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:63233662T>C	uc001nwy.2	-	5	841	c.667A>G	c.(667-669)ATC>GTC	p.I223V	HRASLS5_uc001nwz.2_Missense_Mutation_p.I213V|HRASLS5_uc010rmq.1_Missense_Mutation_p.I223V|HRASLS5_uc009yos.2_RNA	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	223										ovary(1)	1						TACTGCACGATCTTGTTGACC	0.527													0	0	0	0.006122	0	17	46										C	63233662	T	C	63233662	3	2	77	1	0	0	0	0	1	0	0	0	7351	1435	50	5	180	5	HRASLS5	11	63233662	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	8122368	63233662	71772854	220	23249										
PRDX5	25824	broad.mit.edu	37	chr11	64085714	64085714	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctagctggcgtgtgcgccctGagacgctcagcgggctatat	14	12	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:64085714G>A	uc001nzu.2	+	1	146	c.27G>A	c.(25-27)CTG>CTA	p.L9L	TRMT112_uc001nzt.2_5'Flank|PRDX5_uc001nzv.2_Silent_p.L9L|PRDX5_uc001nzw.2_Silent_p.L9L|PRDX5_uc001nzx.2_5'Flank	NM_012094	NP_036226	P30044	PRDX5_HUMAN	peroxiredoxin 5 isoform a precursor	9					cell redox homeostasis|cellular response to reactive oxygen species|inflammatory response|negative regulation of apoptosis	cytosolic part|mitochondrion|peroxisome	caspase inhibitor activity|peroxidase activity|peroxiredoxin activity			breast(1)	1					Auranofin(DB00995)	TGTGCGCCCTGAGACGCTCAG	0.701													0	0	0	0.002445	0	26	95										A	64085714	G	A	64085714	2	1	77	1	0	0	0	0	0	0	0	1	12468	1277	45	1		1	PRDX5	11	64085714	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	852052	64085714	70920802	221	23250										
NRXN2	9379	broad.mit.edu	37	chr11	64480980	64480980	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcgtccaggtagagcagcagCgcgcgcgtggcgttggtgcg	18	11	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:64480980C>A	uc001oar.2	-	3	631	c.192G>T	c.(190-192)GCG>GCT	p.A64A	NRXN2_uc001oas.2_Silent_p.A64A	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	130	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						AGAGCAGCAGCGCGCGCGTGG	0.751													1	0	2.35188e-11	0.006122	2.52239e-11	13	5										A	64480980	C	A	64480980	2	1	77	1	0	0	0	0	0	0	0	1	10666	755	27	4		4	NRXN2	11	64480980	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	395266	64480980	70525536	222	23251										
DKFZp761E198	91056	broad.mit.edu	37	chr11	65547232	65547232	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tccccctctccctcctcagcTgccggccagctgggtgcctg	10	20	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:65547232T>A	uc001ofo.3	-	1	591	c.561A>T	c.(559-561)GCA>GCT	p.A187A		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	187	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		CCTCCTCAGCTGCCGGCCAGC	0.662													0	0	0	0.00361	0	141	115										A	65547232	T	A	65547232	2	1	77	1	0	0	0	0	0	0	0	1	4543	1567	55	5		5	DKFZp761E198	11	65547232	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1066252	65547232	69459284	223	23252										
B3GNT1	11041	broad.mit.edu	37	chr11	66114948	66114948	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggtagagcagctgcagcatCgccaccagcatgagcgcggc	14	13	0	2	rs146812867	byFrequency	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:66114948C>G	uc001ohr.2	-	1	214	c.69G>C	c.(67-69)GCG>GCC	p.A23A	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	23	Helical; Signal-anchor for type II membrane protein; (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						GCTGCAGCATCGCCACCAGCA	0.647													0	0	0	0.00499	0	17	23										G	66114948	C	G	66114948	2	3	77	1	0	0	0	0	0	0	0	1	1256	871	31	1		1	B3GNT1	11	66114948	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	567716	66114948	68891568	224	23253										
TCIRG1	10312	broad.mit.edu	37	chr11	67816717	67816717	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tccacttcatcaacatgttcCtcttctcccacagccccagc	3	19	4	0	rs141780643		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:67816717C>T	uc001one.2	+	15	1951	c.1843C>T	c.(1843-1845)CTC>TTC	p.L615F	TCIRG1_uc001ong.2_Missense_Mutation_p.L399F|TCIRG1_uc001onh.2_Missense_Mutation_p.L317F|TCIRG1_uc001oni.2_Missense_Mutation_p.L119F|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	615	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						CAACATGTTCCTCTTCTCCCA	0.657													0	0	0	0.00361	0	51	175										T	67816717	C	T	67816717	3	4	77	1	0	0	0	0	1	0	0	0	15700	681	24	2	1897	2	TCIRG1	11	67816717	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1701769	67816717	67189799	225	23254										
LRP5	4041	broad.mit.edu	37	chr11	68207303	68207303	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctgatggggggccggggcggGgtgcccctctacgaccggaa	19	12	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:68207303G>T	uc001ont.2	+	21	4482	c.4407G>T	c.(4405-4407)GGG>GGT	p.G1469G	LRP5_uc009ysg.2_Silent_p.G879G	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1469	Cytoplasmic (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GCCGGGGCGGGGTGCCCCTCT	0.632													1	0	9.45814e-24	0.004878	1.05391e-23	28	28										T	68207303	G	T	68207303	2	4	77	1	0	0	0	0	0	0	0	1	8960	1219	43	4		4	LRP5	11	68207303	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	390586	68207303	66799213	226	23255										
MYO7A	4647	broad.mit.edu	37	chr11	76915135	76915135	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccccagctgtgctcaagtacAtgggcgactacccgtccaag	10	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:76915135A>G	uc001oyb.2	+	39	5613	c.5341A>G	c.(5341-5343)ATG>GTG	p.M1781V	MYO7A_uc001oyc.2_Missense_Mutation_p.M1743V|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1781	MyTH4 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCTCAAGTACATGGGCGACTA	0.617													0	0	0	0.000602	0	4	13										G	76915135	A	G	76915135	3	3	77	1	0	0	0	0	1	0	0	0	10082	217	8	5	5525	5	MYO7A	11	76915135	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	8707832	76915135	58091381	227	23256										
MLL	4297	broad.mit.edu	37	chr11	118368671	118368671	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gatgctggtcgtttactataTattggccaaaatgagtggac	11	6	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:118368671T>G	uc001pta.2	+	21	5699	c.5676T>G	c.(5674-5676)TAT>TAG	p.Y1892*	MLL_uc001ptb.2_Nonsense_Mutation_p.Y1895*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1892					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GTTTACTATATATTGGCCAAA	0.378			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.003163	0	13	27										G	118368671	T	G	118368671	4	3	77	1	0	0	0	0	0	1	0	0	9620	1413	49	5	5758	5	MLL	11	118368671	Nonsense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	41453536	118368671	16637845	228	23257										
HSPA8	3312	broad.mit.edu	37	chr11	122929417	122929417	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agacattgagtataccattgGcatcaatgtcaaaagtgact	8	7	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:122929417G>A	uc001pyo.2	-	7	1523	c.1445C>T	c.(1444-1446)GCC>GTC	p.A482V	HSPA8_uc009zbc.2_Missense_Mutation_p.A246V|HSPA8_uc001pyp.2_Intron|HSPA8_uc010rzu.1_Missense_Mutation_p.A405V	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	482					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TATACCATTGGCATCAATGTC	0.448													0	0	0	0.009535	0	29	35										A	122929417	G	A	122929417	3	1	77	1	0	0	0	0	1	0	0	0	7416	1203	42	2	507	2	HSPA8	11	122929417	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4560746	122929417	12077099	229	23258										
WNK1	65125	broad.mit.edu	37	chr12	989117	989117	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acccacagctcctacaaccaGcagttcagtccatgggaata	7	14	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:989117G>T	uc001qio.3	+	11	3259	c.2752G>T	c.(2752-2754)GCA>TCA	p.A918S	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	918					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCTACAACCAGCAGTTCAGTC	0.512													1	0	3.86236e-30	0.00361	4.3604e-30	39	41										T	989117	G	T	989117	3	4	77	1	0	0	0	0	1	0	0	0	17374	971	34	4	4296	4	WNK1	12	989117	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08		989117	132862778	230	23259										
WNK1	65125	broad.mit.edu	37	chr12	994164	994164	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtggtaacttcaggtggtctCcccataccacctgtgtctga	10	12	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:994164C>T	uc001qio.3	+	19	4701	c.4194C>T	c.(4192-4194)CTC>CTT	p.L1398L	WNK1_uc001qip.3_Silent_p.L1151L|WNK1_uc001qir.3_Silent_p.L571L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1398					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CAGGTGGTCTCCCCATACCAC	0.478													0	0	0	0.004878	0	34	34										T	994164	C	T	994164	2	4	77	1	0	0	0	0	0	0	0	1	17374	842	30	1		1	WNK1	12	994164	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5047	994164	132857731	231	23260										
SCNN1A	6337	broad.mit.edu	37	chr12	6471317	6471317	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctctggcagcctcgacaggaTgttgatgtagtggaagcggt	15	8	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:6471317T>C	uc001qnx.2	-	4	1064	c.775A>G	c.(775-777)ATC>GTC	p.I259V	SCNN1A_uc001qnv.2_5'UTR|SCNN1A_uc001qnw.2_Missense_Mutation_p.I318V|SCNN1A_uc010sfb.1_Missense_Mutation_p.I282V	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	259	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CTCGACAGGATGTTGATGTAG	0.572													0	0	0	0.002096	0	29	91										C	6471317	T	C	6471317	3	2	77	1	0	0	0	0	1	0	0	0	13927	1464	51	5	1274	5	SCNN1A	12	6471317	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	5477153	6471317	127380578	232	23261										
IFFO1	25900	broad.mit.edu	37	chr12	6649704	6649706	+	In_Frame_Del	DEL	GGC	GGC	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cggagtcctcagcctcgcttGgcggcggcggcgggtcgcta					rs144019095		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:6649704_6649706delGGC	uc001qpd.1	-	9	1657_1659	c.1623_1625delGCC	c.(1621-1626)CCGCCA>CCA	p.541_542PP>P	IFFO1_uc001qoy.2_RNA|IFFO1_uc001qpa.1_In_Frame_Del_p.181_182PP>P|IFFO1_uc001qpb.1_In_Frame_Del_p.218_219PP>P|IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_In_Frame_Del_p.553_554PP>P|IFFO1_uc001qpf.1_In_Frame_Del_p.544_545PP>P|IFFO1_uc001qoz.1_In_Frame_Del_p.182_183PP>P|IFFO1_uc001qpc.1_In_Frame_Del_p.545_546PP>P|IFFO1_uc001qpg.2_In_Frame_Del_p.R181del	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	541_542	Poly-Pro.					intermediate filament					0						AGCCTCGCTTGGCGGCGGCGGCG	0.601																		14	188	---	---								-	6649706	GGC	-	6649704	7	5	77	1	0	1	0	1	0	0	0	0	7510	1348	47	0	58	0	IFFO1	12	6649704	In_Frame_Del	DEL	GGC	TCGA-FD-A3N5-01A-11D-A21A-08	178387	6649704	127202191	233	23262										
NECAP1	25977	broad.mit.edu	37	chr12	8245362	8245362	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggcttcaaggaaggacaaacCatcaagttgtgtatcggggt	13	7	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:8245362C>G	uc001qtx.2	+	5	552	c.474C>G	c.(472-474)ACC>ACG	p.T158T	NECAP1_uc001qty.2_Silent_p.T16T	NM_015509	NP_056324	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	158					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				ovary(1)	1				Kidney(36;0.0915)		AAGGACAAACCATCAAGTTGT	0.403													0	0	0	0.001368	0	9	13										G	8245362	C	G	8245362	2	3	77	1	0	0	0	0	0	0	0	1	10307	581	21	4		4	NECAP1	12	8245362	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1595658	8245362	125606533	234	23263										
KIF21A	55605	broad.mit.edu	37	chr12	39763563	39763563	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggcattcactttaaaatctgGagcaggaagcccatttttaa	8	8	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:39763563G>T	uc001rly.2	-	3	564	c.418C>A	c.(418-420)CCA>ACA	p.P140T	KIF21A_uc001rlx.2_Missense_Mutation_p.P140T|KIF21A_uc001rlz.2_Missense_Mutation_p.P140T|KIF21A_uc010skl.1_Missense_Mutation_p.P140T|KIF21A_uc001rma.1_Missense_Mutation_p.P140T	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	140	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TTAAAATCTGGAGCAGGAAGC	0.299													1	0	2.56e-06	0.009096	2.64e-06	4	8										T	39763563	G	T	39763563	3	4	77	1	0	0	0	0	1	0	0	0	8288	1174	41	3	4750	3	KIF21A	12	39763563	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	31518201	39763563	94088332	235	23264										
NELL2	4753	broad.mit.edu	37	chr12	44917077	44917077	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttttcatttataccaacctgAcatgagcacacagagcacct	5	12	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:44917077A>G	uc001rog.2	-	17	2590	c.1995T>C	c.(1993-1995)TGT>TGC	p.C665C	NELL2_uc001rof.3_Silent_p.C664C|NELL2_uc001roh.2_Silent_p.C665C|NELL2_uc009zkd.2_Silent_p.C617C|NELL2_uc010skz.1_Silent_p.C715C|NELL2_uc010sla.1_Silent_p.C688C|NELL2_uc001roi.1_Silent_p.C665C	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	665	VWFC 3.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TACCAACCTGACATGAGCACA	0.259													0	0	0	0.004289	0	35	65										G	44917077	A	G	44917077	2	3	77	1	0	0	0	0	0	0	0	1	10334	273	10	5		5	NELL2	12	44917077	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5153514	44917077	88934818	236	23265										
ARID2	196528	broad.mit.edu	37	chr12	46287258	46287258	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gagcacaaaaggccattgtgAatcatcccagtgctgcactt	9	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:46287258A>T	uc001ros.1	+	19	5203	c.5203A>T	c.(5203-5205)AAT>TAT	p.N1735Y	ARID2_uc001ror.2_Missense_Mutation_p.N1735Y|ARID2_uc009zkg.1_Missense_Mutation_p.N1191Y|ARID2_uc009zkh.1_Missense_Mutation_p.N1362Y|ARID2_uc001rou.1_Missense_Mutation_p.N1069Y	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1735					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GGCCATTGTGAATCATCCCAG	0.393													0	0	0	0.009096	0	3	20										T	46287258	A	T	46287258	3	4	77	1	0	0	0	0	1	0	0	0	915	246	9	5	5277	5	ARID2	12	46287258	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1370181	46287258	87564637	237	23266										
DHH	50846	broad.mit.edu	37	chr12	49488197	49488197	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agctgcttgcgcgcatagcgGcgccggccaaccggcccccg	14	18	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:49488197G>A	uc001rtf.2	-	1	406	c.99C>T	c.(97-99)CGC>CGT	p.R33R		NM_021044	NP_066382	O43323	DHH_HUMAN	desert hedgehog preproprotein	33					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			lung(1)|breast(1)	2						GCGCATAGCGGCGCCGGCCAA	0.602													0	0	0	0.000978	0	11	26										A	49488197	G	A	49488197	2	1	77	1	0	0	0	0	0	0	0	1	4483	1190	42	2		2	DHH	12	49488197	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3200939	49488197	84363698	238	23267										
ZNF385A	25946	broad.mit.edu	37	chr12	54765302	54765302	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagggagttcacagccacctTgcacagagcacagtagagca	11	12	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:54765302T>C	uc001sfw.1	-	4	742	c.559A>G	c.(559-561)AAG>GAG	p.K187E	ZNF385A_uc001sfv.1_Missense_Mutation_p.K168E|ZNF385A_uc009zno.1_RNA|ZNF385A_uc010sov.1_Intron|ZNF385A_uc001sfx.1_Missense_Mutation_p.K187E|ZNF385A_uc001sfy.3_Missense_Mutation_p.K207E|ZNF385A_uc001sfz.3_Intron	NM_015481	NP_056296	Q96PM9	Z385A_HUMAN	zinc finger protein 385A isoform c	187	Matrin-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1						ACAGCCACCTTGCACAGAGCA	0.612													0	0	0	0.00361	0	96	83										C	54765302	T	C	54765302	3	2	77	1	0	0	0	0	1	0	0	0	17873	1821	63	5	557	5	ZNF385A	12	54765302	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	5277105	54765302	79086593	239	23268										
ZC3H10	84872	broad.mit.edu	37	chr12	56515604	56515604	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccaccactcccatggtgactTaccctatcgcttcccagagc	6	18	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:56515604T>C	uc001sjp.1	+	3	1447	c.1258T>C	c.(1258-1260)TAC>CAC	p.Y420H		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	420							nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			CATGGTGACTTACCCTATCGC	0.602													0	0	0	0.00361	0	45	31										C	56515604	T	C	56515604	3	2	77	1	0	0	0	0	1	0	0	0	17556	1754	61	5	1260	5	ZC3H10	12	56515604	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1750302	56515604	77336291	240	23269										
LRP1	4035	broad.mit.edu	37	chr12	57572754	57572754	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctacaaccggaccgtgtcctGcgcctgcccccacctcatga	8	19	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:57572754G>T	uc001snd.2	+	28	5154	c.4688G>T	c.(4687-4689)TGC>TTC	p.C1563F		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1563	EGF-like 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACCGTGTCCTGCGCCTGCCCC	0.632													1	0	1.39691e-52	0.00361	1.62405e-52	87	119										T	57572754	G	T	57572754	3	4	77	1	0	0	0	0	1	0	0	0	8951	1319	46	4	4798	4	LRP1	12	57572754	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1057150	57572754	76279141	241	23270										
LRP1	4035	broad.mit.edu	37	chr12	57598266	57598266	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctggcctggaagtgcgatggCgaggatgactgtggggacaa	18	7	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:57598266C>T	uc001snd.2	+	71	11491	c.11025C>T	c.(11023-11025)GGC>GGT	p.G3675G		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3675	Extracellular (Potential).|LDL-receptor class A 29.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGTGCGATGGCGAGGATGACT	0.632													0	0	0	0.002836	0	30	107										T	57598266	C	T	57598266	2	4	77	1	0	0	0	0	0	0	0	1	8951	755	27	2		2	LRP1	12	57598266	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	25512	57598266	76253629	242	23271										
MBD6	114785	broad.mit.edu	37	chr12	57919889	57919889	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttcgattgctagaagggagaGgccctcaaacccctagacgg	12	11	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:57919889G>C	uc001soj.1	+	6	1362	c.1138G>C	c.(1138-1140)GGC>CGC	p.G380R	MBD6_uc001sok.1_Missense_Mutation_p.G247R|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	380	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						AGAAGGGAGAGGCCCTCAAAC	0.617													0	0	0	0.00361	0	77	77										C	57919889	G	C	57919889	3	2	77	1	0	0	0	0	1	0	0	0	9348	1000	35	4	1152	4	MBD6	12	57919889	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	321623	57919889	75932006	243	23272										
USP15	9958	broad.mit.edu	37	chr12	62785202	62785202	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tttgatgataggcagcttagGctagatggtaagtatttgtg	13	3	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:62785202G>A	uc001src.1	+	16	2235	c.2226G>A	c.(2224-2226)AGG>AGA	p.R742R	USP15_uc001srb.1_Silent_p.R713R	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	742					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GGCAGCTTAGGCTAGATGGTA	0.343													0	0	0	0.00278	0	17	9										A	62785202	G	A	62785202	2	1	77	1	0	0	0	0	0	0	0	1	17043	1194	42	2		2	USP15	12	62785202	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4865313	62785202	71066693	244	23273										
WIF1	11197	broad.mit.edu	37	chr12	65514281	65514281	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgttgtgcttttctgaaatcAtgtgtaaaaggtgccatttt	9	5	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:65514281A>G	uc001ssk.2	-	2	349	c.204T>C	c.(202-204)CAT>CAC	p.H68H		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	68	WIF.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TTCTGAAATCATGTGTAAAAG	0.378			T	HMGA2	pleomorphic salivary gland adenoma								0	0	0	0.004656	0	20	19										G	65514281	A	G	65514281	2	3	77	1	0	0	0	0	0	0	0	1	17363	214	8	5		5	WIF1	12	65514281	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	2729079	65514281	68337614	245	23274										
TMBIM4	51643	broad.mit.edu	37	chr12	66531850	66531850	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctcttcaggtgacagtttatGcatcagtgagtgtgtgtcat	11	7	4	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:66531850G>A	uc001stc.2	-	7	683	c.607C>T	c.(607-609)CAT>TAT	p.H203Y	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Missense_Mutation_p.H172Y|TMBIM4_uc009zqr.2_Missense_Mutation_p.H250Y|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	203						integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		GACAGTTTATGCATCAGTGAG	0.413													0	0	0	0.008291	0	8	33										A	66531850	G	A	66531850	3	1	77	1	0	0	0	0	1	0	0	0	15979	1319	46	2	113	2	TMBIM4	12	66531850	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1017569	66531850	67320045	246	23275										
LYZ	4069	broad.mit.edu	37	chr12	69746950	69746950	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagggtggcatggagaaatcGttgtcaaaacagagatgtcc	13	7	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:69746950G>A	uc001suw.2	+	4	453	c.398G>A	c.(397-399)CGT>CAT	p.R133H		NM_000239	NP_000230	P61626	LYSC_HUMAN	lysozyme precursor	133					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding				0	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			TGGAGAAATCGTTGTCAAAAC	0.398													0	0	0	0.002836	0	27	40										A	69746950	G	A	69746950	3	1	77	1	0	0	0	0	1	0	0	0	9130	1145	40	2	412	2	LYZ	12	69746950	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3215100	69746950	64104945	247	23276										
ALX1	8092	broad.mit.edu	37	chr12	85694982	85694982	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagtggtggttctgtggttaCttcatgcatgttaccacgtg	12	7	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:85694982C>A	uc001tae.3	+	4	714	c.710C>A	c.(709-711)ACT>AAT	p.T237N		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	237					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TCTGTGGTTACTTCATGCATG	0.408													1	0	1.04594e-18	0.00623	1.15349e-18	30	39										A	85694982	C	A	85694982	3	1	77	1	0	0	0	0	1	0	0	0	556	565	20	4	724	4	ALX1	12	85694982	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	15948032	85694982	48156913	248	23277										
PAH	5053	broad.mit.edu	37	chr12	103246694	103246694	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaatcccgagaggaaagcagGccagccacaggtcggaggcg	15	11	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:103246694G>A	uc001tjq.1	-	8	1213	c.741C>T	c.(739-741)GGC>GGT	p.G247G		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	247			G -> V (in PKU; haplotype 4).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	AGGAAAGCAGGCCAGCCACAG	0.537													0	0	0	0.003163	0	11	18										A	103246694	G	A	103246694	2	1	77	1	0	0	0	0	0	0	0	1	11394	1190	42	2		2	PAH	12	103246694	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	17551712	103246694	30605201	249	23278										
FICD	11153	broad.mit.edu	37	chr12	108912880	108912880	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aagcagatgcaggagtttgtAcagtggctcaactccgagga	13	8	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:108912880A>G	uc001tmx.1	+	3	1151	c.1005A>G	c.(1003-1005)GTA>GTG	p.V335V		NM_007076	NP_009007	Q9BVA6	FICD_HUMAN	Huntingtin interacting protein E	335	Fido.				negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity				0						AGGAGTTTGTACAGTGGCTCA	0.542													0	0	0	0.003214	0	43	38										G	108912880	A	G	108912880	2	3	77	1	0	0	0	0	0	0	0	1	5887	378	14	5		5	FICD	12	108912880	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5666186	108912880	24939015	250	23279										
CIT	11113	broad.mit.edu	37	chr12	120288005	120288006	+	Missense_Mutation	DNP	GG	GG	TT													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggtgatttttgtcctgaaaGgcatactgtaattgggggat							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:120288005_120288006GG>TT	uc001txi.1	-	5	541_542	c.488_489CC>AA	c.(487-489)GCC>GAA	p.A163E	CIT_uc001txj.1_Missense_Mutation_p.A163E	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	163	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGTCCTGAAAGGCATACTGTAA	0.426													0	0	0	0.004672	0	60	75										TT	120288006	GG	TT	120288005	3	4	77	1	0	0	0	0	1	0	0	0	3438	987	35	4	5766	4	CIT	12	120288005	Missense_Mutation	DNP	GG	TCGA-FD-A3N5-01A-11D-A21A-08	11375125	120288005	13563890	251	23280										
KDM2B	84678	broad.mit.edu	37	chr12	121947735	121947735	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cctgtccctgccctcgccctCctcgtccttctcctcctcct	4	24	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:121947735C>A	uc001uat.2	-	11	1386	c.1282G>T	c.(1282-1284)GAG>TAG	p.E428*	KDM2B_uc001uar.2_Nonsense_Mutation_p.E19*|KDM2B_uc001uas.2_Nonsense_Mutation_p.E397*|KDM2B_uc001uau.2_Nonsense_Mutation_p.E311*|KDM2B_uc001uav.3_Nonsense_Mutation_p.E338*	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	428	Glu-rich.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTCGCcctcctcgtccttc	0.562													1	0	4.14922e-12	0.004007	4.4724e-12	12	34										A	121947735	C	A	121947735	4	1	77	1	0	0	0	0	0	1	0	0	8125	864	30	3	2832	3	KDM2B	12	121947735	Nonsense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1659730	121947735	11904160	252	23281										
BRI3BP	140707	broad.mit.edu	37	chr12	125497182	125497182	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggatgttcttggacttgacGgtaggtgtaggggtggcatt	17	4	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:125497182G>A	uc001uha.1	+	2	459	c.316G>A	c.(316-318)GTC>ATC	p.V106I		NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	BRI3-binding protein	106						integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		TGGACTTGACGGTAGGTGTAG	0.488													0	0	0	0.009535	0	25	112										A	125497182	G	A	125497182	3	1	77	1	0	0	0	0	1	0	0	0	1513	1130	39	2	322	2	BRI3BP	12	125497182	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3549447	125497182	8354713	253	23282										
ATP8A2	51761	broad.mit.edu	37	chr13	26129158	26129158	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atgtattatataggaaatgaCactcctgccatggccaggac	9	9	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:26129158C>A	uc001uqk.2	+	13	1357	c.1215C>A	c.(1213-1215)GAC>GAA	p.D405E	ATP8A2_uc010tdi.1_Missense_Mutation_p.D365E|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.D365E	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	365	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TAGGAAATGACACTCCTGCCA	0.408													1	0	2.74318e-10	0.006214	2.92016e-10	7	22										A	26129158	C	A	26129158	3	1	77	1	0	0	0	0	1	0	0	0	1193	477	17	4	1265	4	ATP8A2	13	26129158	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		26129158	89040720	254	23283										
KL	9365	broad.mit.edu	37	chr13	33628356	33628356	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tttgtctcagggaccaccaaGagagatgatgccaaatatat	9	8	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:33628356G>C	uc001uus.2	+	2	1280	c.1272G>C	c.(1270-1272)AAG>AAC	p.K424N	KL_uc001uur.1_Missense_Mutation_p.K117N	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	424	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GGACCACCAAGAGAGATGATG	0.393													0	0	0	0.00333	0	22	19										C	33628356	G	C	33628356	3	2	77	1	0	0	0	0	1	0	0	0	8331	933	33	1	1278	1	KL	13	33628356	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	7499198	33628356	81541522	255	23284										
HTR2A	3356	broad.mit.edu	37	chr13	47409473	47409473	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atagtcctcctgcctgtgtaGgaccctggctccctatggat	10	13	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:47409473G>A	uc001vbq.2	-	3	1049	c.915C>T	c.(913-915)TCC>TCT	p.S305S	HTR2A_uc001vbr.2_Silent_p.S205S|HTR2A_uc010acr.2_Silent_p.S305S	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	305	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGCCTGTGTAGGACCCTGGCT	0.522													0	0	0	0.001168	0	6	4										A	47409473	G	A	47409473	2	1	77	1	0	0	0	0	0	0	0	1	7441	987	35	2		2	HTR2A	13	47409473	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	13781117	47409473	67760405	256	23285										
RB1	5925	broad.mit.edu	37	chr13	49050846	49050846	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtaatttgtagacttctgagAagttccagaaaataaatcag	8	5	2	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:49050846A>T	uc001vcb.2	+	25	2696	c.2530A>T	c.(2530-2532)AAG>TAG	p.K844*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	844	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GACTTCTGAGAAGTTCCAGAA	0.363		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.001984	0	5	4										T	49050846	A	T	49050846	4	4	77	1	0	0	0	0	0	1	0	0	13098	247	9	5	2628	5	RB1	13	49050846	Nonsense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1641373	49050846	66119032	257	23286										
DCT	1638	broad.mit.edu	37	chr13	95117984	95117984	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaacagctggtctgtacacaCatcacactcgttcctcccag	6	15	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:95117984C>T	uc001vlv.3	-	4	1193	c.766G>A	c.(766-768)GTG>ATG	p.V256M	DCT_uc010afh.2_Missense_Mutation_p.V256M	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	256	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TCTGTACACACATCACACTCG	0.493													0	0	0	0.004656	0	20	40										T	95117984	C	T	95117984	3	4	77	1	0	0	0	0	1	0	0	0	4304	478	17	2	920	2	DCT	13	95117984	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	46067138	95117984	20051894	258	23287										
CLDN10	9071	broad.mit.edu	37	chr13	96205153	96205168	+	Frame_Shift_Del	DEL	TGTGGAAGGCGTGCGT	TGTGGAAGGCGTGCGT	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cgccacctattgggccaaccTgtggaaggcgtgcgttaccg							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:96205153_96205168delTGTGGAAGGCGTGCGT	uc001vmh.2	+	1	207_222	c.146_161delTGTGGAAGGCGTGCGT	c.(145-162)CTGTGGAAGGCGTGCGTTfs	p.L49fs	CLDN10_uc001vmg.2_Intron|CLDN10_uc010tii.1_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	49_54	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			TGGGCCAACCTGTGGAAGGCGTGCGTTACCGACTCC	0.644																		24	210	---	---								-	96205168	TGTGGAAGGCGTGCGT	-	96205153	7	5	77	1	0	1	0	1	0	0	0	0	3472	1580	55	0	366	0	CLDN10	13	96205153	Frame_Shift_Del	DEL	TGTGGAAGGCGTGCGT	TCGA-FD-A3N5-01A-11D-A21A-08	1087169	96205153	18964725	259	23288										
IPO5	3843	broad.mit.edu	37	chr13	98641409	98641409	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	actgcgggaagctgcccttcAcattttctggtatatacatt	8	10	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:98641409A>G	uc001vnf.1	+	4	523	c.458A>G	c.(457-459)CAC>CGC	p.H153R	IPO5_uc001vne.2_Missense_Mutation_p.H171R|IPO5_uc010tik.1_Intron|IPO5_uc010til.1_Missense_Mutation_p.H93R	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	153					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GCTGCCCTTCACATTTTCTGG	0.373													0	0	0	0.000978	0	10	10										G	98641409	A	G	98641409	3	3	77	1	0	0	0	0	1	0	0	0	7796	159	6	5	530	5	IPO5	13	98641409	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	2436256	98641409	16528469	260	23289										
EFNB2	1948	broad.mit.edu	37	chr13	107145643	107145643	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgtctcctccggtacttcagCaagaggaccaccagcgtgat	10	13	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:107145643C>T	uc001vqi.2	-	5	772	c.747G>A	c.(745-747)TTG>TTA	p.L249L		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	249	Helical; (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					GGTACTTCAGCAAGAGGACCA	0.522													0	0	0	0.00361	0	57	111										T	107145643	C	T	107145643	2	4	77	1	0	0	0	0	0	0	0	1	4956	709	25	2		2	EFNB2	13	107145643	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	8504234	107145643	8024235	261	23290										
OR4M1	441670	broad.mit.edu	37	chr14	20249060	20249060	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	attgcctgtgccaacaccttCccagaggagttagtgatgat	10	10	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:20249060C>G	uc010tku.1	+	1	579	c.579C>G	c.(577-579)TTC>TTG	p.F193L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCAACACCTTCCCAGAGGAGT	0.478													0	0	0	0.003755	0	28	82										G	20249060	C	G	20249060	3	3	77	1	0	0	0	0	1	0	0	0	11075	854	30	1	581	1	OR4M1	14	20249060	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		20249060	87100480	262	23291										
SUPT16H	11198	broad.mit.edu	37	chr14	21834657	21834657	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgctttttaaccacgtccatGacagcgttatacacgtcaca	6	12	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:21834657G>T	uc001wao.2	-	8	1326	c.987C>A	c.(985-987)GTC>GTA	p.V329V		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	329					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CCACGTCCATGACAGCGTTAT	0.348													1	0	4.7546e-09	0.004007	4.97494e-09	12	85										T	21834657	G	T	21834657	2	4	77	1	0	0	0	0	0	0	0	1	15393	1277	45	3		3	SUPT16H	14	21834657	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1585597	21834657	85514883	263	23292										
EFS	10278	broad.mit.edu	37	chr14	23826494	23826494	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggcctgccctgccagttctgTtacacactgcaccatctctt	7	16	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:23826494T>A	uc001wjo.2	-	6	2235	c.1627A>T	c.(1627-1629)ACA>TCA	p.T543S	EFS_uc001wjp.2_Missense_Mutation_p.T450S|EFS_uc010tnm.1_Missense_Mutation_p.T374S	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	543					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GCCAGTTCTGTTACACACTGC	0.612													0	0	0	0.004289	0	31	101										A	23826494	T	A	23826494	3	1	77	1	0	0	0	0	1	0	0	0	4959	1725	60	5	62	5	EFS	14	23826494	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1991837	23826494	83523046	264	23293										
DHRS4L1	728635	broad.mit.edu	37	chr14	24518021	24518021	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agactagcttcagcaggatgGtgaggaaggggagctttgca	16	6	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:24518021G>C	uc010alc.2	+	8	675	c.675_splice	c.e8+1	p.M225_splice	DHRS4L1_uc010tnu.1_Splice_Site	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4								binding|oxidoreductase activity				0						CAGCAGGATGGTGAGGAAGGG	0.547													0	0	0	0.00632	0	17	109										C	24518021	G	C	24518021	5	2	77	1	0	0	0	0	0	0	1	0	4493	1275	44	4	706	4	DHRS4L1	14	24518021	Splice_Site	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	691527	24518021	82831519	265	23294										
RALGAPA1	253959	broad.mit.edu	37	chr14	36277976	36277976	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgaggcgagtcagtgcgtcCttcttggtgtctagcacctt	12	10	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:36277976C>T	uc001wti.2	-	1	457	c.66G>A	c.(64-66)AAG>AAA	p.K22K	RALGAPA1_uc001wtj.2_Silent_p.K22K|RALGAPA1_uc010tpv.1_Silent_p.K22K|RALGAPA1_uc010tpw.1_Silent_p.K22K	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	22					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TCAGTGCGTCCTTCTTGGTGT	0.557													0	0	0	0.004289	0	28	25										T	36277976	C	T	36277976	2	4	77	1	0	0	0	0	0	0	0	1	13013	680	24	2		2	RALGAPA1	14	36277976	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	11759955	36277976	71071564	266	23295										
SSTR1	6751	broad.mit.edu	37	chr14	38679681	38679681	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccgcgctcaagagccgtgccTacagtgtggaagacttccaa	11	13	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:38679681T>C	uc001wul.1	+	3	1704	c.1087T>C	c.(1087-1089)TAC>CAC	p.Y363H	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	363	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GAGCCGTGCCTACAGTGTGGA	0.617													0	0	0	0.00361	0	118	62										C	38679681	T	C	38679681	3	2	77	1	0	0	0	0	1	0	0	0	15196	1522	53	5	1089	5	SSTR1	14	38679681	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2401705	38679681	68669859	267	23296										
SYNE2	23224	broad.mit.edu	37	chr14	64408416	64408416	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cttgtgaccttctgcagcacActtctccctcagttatatcc	5	15	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:64408416A>G	uc001xgm.2	+	4	375	c.145A>G	c.(145-147)ACT>GCT	p.T49A	SYNE2_uc001xgk.2_Missense_Mutation_p.T49A|SYNE2_uc001xgl.2_Missense_Mutation_p.T49A	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	49	CH 1.|Cytoplasmic (Potential).|Actin-binding.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCTGCAGCACACTTCTCCCTC	0.373													0	0	0	0.004482	0	7	42										G	64408416	A	G	64408416	3	3	77	1	0	0	0	0	1	0	0	0	15443	159	6	5	155	5	SYNE2	14	64408416	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	25728735	64408416	42941124	268	23297										
C14orf50	145376	broad.mit.edu	37	chr14	65031546	65031546	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgcagaaactgatggtccagCttcagacaggtagattaact	10	8	1	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:65031546C>T	uc001xhl.1	+	4	356	c.260C>T	c.(259-261)GCT>GTT	p.A87V		NM_172365	NP_758953	Q96LQ0	CN050_HUMAN	hypothetical protein LOC145376	87										skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)		GATGGTCCAGCTTCAGACAGG	0.408													0	0	0	0.00361	0	41	67										T	65031546	C	T	65031546	3	4	77	1	0	0	0	0	1	0	0	0	1777	797	28	2	274	2	C14orf50	14	65031546	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	623130	65031546	42317994	269	23298										
PLEKHG3	26030	broad.mit.edu	37	chr14	65203599	65203599	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaacacctgctcaggcaactCaacgagaaaggtgagtgtgt	11	9	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:65203599C>G	uc001xho.1	+	13	1643	c.1374C>G	c.(1372-1374)CTC>CTG	p.L458L	PLEKHG3_uc001xhn.1_Silent_p.L402L|PLEKHG3_uc001xhp.2_Silent_p.L458L|PLEKHG3_uc010aqh.1_5'UTR|PLEKHG3_uc001xhq.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	458				QGRRQSEPTKHLLRQLNEKARAAGMK -> KGAGPEPPGSE EEEEEQEESLAVAEQ (in Ref. 2; AAH04298).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TCAGGCAACTCAACGAGAAAG	0.617													0	0	0	0.002836	0	27	84										G	65203599	C	G	65203599	2	3	77	1	0	0	0	0	0	0	0	1	12070	813	29	1		1	PLEKHG3	14	65203599	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	172053	65203599	42145941	270	23299										
FUT8	2530	broad.mit.edu	37	chr14	66028339	66028339	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcattctttttgcctgggggAccttgctgttttatataggt	10	7	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:66028339A>C	uc001xin.2	+	3	1255	c.58A>C	c.(58-60)ACC>CCC	p.T20P	FUT8_uc001xio.2_Missense_Mutation_p.T20P|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.T20P|FUT8_uc001xiq.2_Intron	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	20	Helical; Signal-anchor for type II membrane protein; (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TGCCTGGGGGACCTTGCTGTT	0.473													0	0	0	0.00361	0	70	52										C	66028339	A	C	66028339	3	2	77	1	0	0	0	0	1	0	0	0	6110	275	10	5	60	5	FUT8	14	66028339	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	824740	66028339	41321201	271	23300										
ZFYVE26	23503	broad.mit.edu	37	chr14	68233024	68233024	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aacagcagctgcttcatgatGtccgtgagcagcccggcatc	11	13	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:68233024G>A	uc001xka.2	-	32	6070	c.5931C>T	c.(5929-5931)GAC>GAT	p.D1977D	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.D1977D	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1977					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCTTCATGATGTCCGTGAGCA	0.587													0	0	0	0.00361	0	45	128										A	68233024	G	A	68233024	2	1	77	1	0	0	0	0	0	0	0	1	17665	1368	48	2		2	ZFYVE26	14	68233024	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2204685	68233024	39116516	272	23301										
HEATR4	399671	broad.mit.edu	37	chr14	73964942	73964942	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccttgaagtttcagggctagGatgctacggcaagcttccag	12	10	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:73964942G>T	uc010tub.1	-	14	2785	c.2463C>A	c.(2461-2463)ATC>ATA	p.I821I	HEATR4_uc010tua.1_Silent_p.I774I	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TCAGGGCTAGGATGCTACGGC	0.537													1	0	4.65686e-17	0.003755	5.10945e-17	29	22										T	73964942	G	T	73964942	2	4	77	1	0	0	0	0	0	0	0	1	7030	1164	41	3		3	HEATR4	14	73964942	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5731918	73964942	33384598	273	23302										
ATXN3	4287	broad.mit.edu	37	chr14	92555135	92555135	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctgatattaattctggaccCgtcaagagagaattcaagtt	8	7	4	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:92555135C>G	uc001yac.3	-	6	483	c.414G>C	c.(412-414)ACG>ACC	p.T138T	ATXN3_uc010aug.2_Silent_p.T123T|ATXN3_uc001yad.3_Silent_p.T83T|ATXN3_uc010auh.2_Silent_p.T72T|ATXN3_uc001yae.3_Silent_p.T40T|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	138	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		ATTCTGGACCCGTCAAGAGAG	0.318													0	0	0	0.00361	0	59	43										G	92555135	C	G	92555135	2	3	77	1	0	0	0	0	0	0	0	1	1213	639	23	4		4	ATXN3	14	92555135	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	18590193	92555135	14794405	274	23303										
BCL11B	64919	broad.mit.edu	37	chr14	99723962	99723962	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gggctgtccttgtccagggcCttgtcatagcaggcacccaa	12	13	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:99723962C>T	uc001yga.2	-	2	540	c.273G>A	c.(271-273)AAG>AAA	p.K91K	BCL11B_uc001ygb.2_Silent_p.K91K	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	91						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TGTCCAGGGCCTTGTCATAGC	0.587			T	TLX3	T-ALL								0	0	0	0.00361	0	131	84										T	99723962	C	T	99723962	2	4	77	1	0	0	0	0	0	0	0	1	1364	680	24	2		2	BCL11B	14	99723962	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	7168827	99723962	7625578	275	23304										
RTL1	388015	broad.mit.edu	37	chr14	101351019	101351019	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cccgcactccactgcccgacGtcgcctcggtggtgttggat	12	16	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:101351019G>A	uc010txj.1	-	1	166	c.107C>T	c.(106-108)ACG>ATG	p.T36M	uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	36										pancreas(1)	1						ACTGCCCGACGTCGCCTCGGT	0.587													0	0	0	0.00499	0	12	41										A	101351019	G	A	101351019	3	1	77	1	0	0	0	0	1	0	0	0	13724	1145	40	2	3973	2	RTL1	14	101351019	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	1627057	101351019	5998521	276	23305										
HSP90AA1	3320	broad.mit.edu	37	chr14	102605682	102605682	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcactctgggcgggacagtcCctgtcccgaagggagggccc	16	14	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:102605682C>T	uc001ykv.3	-	1	405	c.60G>A	c.(58-60)AGG>AGA	p.R20R	WDR20_uc001yky.1_5'Flank|WDR20_uc001yla.2_5'Flank|WDR20_uc001ykz.2_5'Flank|WDR20_uc001ylb.2_5'Flank|WDR20_uc010txu.1_5'Flank|WDR20_uc001ylc.2_5'Flank|WDR20_uc001yld.2_5'Flank|WDR20_uc001yle.2_5'Flank|WDR20_uc001ylf.2_5'Flank	NM_001017963	NP_001017963	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 1	Error:Variant_position_missing_in_P07900_after_alignment					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CGGGACAGTCCCTGTCCCGAA	0.706													0	0	0	0.00333	0	24	11										T	102605682	C	T	102605682	2	4	77	1	0	0	0	0	0	0	0	1	7401	622	22	2		2	HSP90AA1	14	102605682	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1254663	102605682	4743858	277	23306										
FMN1	342184	broad.mit.edu	37	chr15	33360066	33360066	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acacatcactgccatccagaGaattatcaacgttctccatg	5	13	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:33360066G>A	uc001zhf.3	-	1	20	c.20C>T	c.(19-21)TCT>TTT	p.S7F	FMN1_uc001zhg.2_Missense_Mutation_p.S7F	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GCCATCCAGAGAATTATCAAC	0.468													0	0	0	0.008291	0	8	26										A	33360066	G	A	33360066	3	1	77	1	0	0	0	0	1	0	0	0	5949	942	33	1	3638	1	FMN1	15	33360066	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08		33360066	69171326	278	23307										
ACTC1	70	broad.mit.edu	37	chr15	35084467	35084467	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcttctctttaatgtcacggAcaatttcacgttcagctaca	6	11	4	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:35084467A>G	uc001ziu.1	-	5	875	c.632T>C	c.(631-633)GTC>GCC	p.V211A	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	211					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AATGTCACGGACAATTTCACG	0.468													0	0	0	0.001855	0	12	8										G	35084467	A	G	35084467	3	3	77	1	0	0	0	0	1	0	0	0	195	275	10	5	513	5	ACTC1	15	35084467	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1724401	35084467	67446925	279	23308										
MYO5C	55930	broad.mit.edu	37	chr15	52534274	52534274	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cctcctccttgccaggaatcCtcggctgtaggcctgcattg	10	15	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:52534274C>A	uc010bff.2	-	20	2664	c.2527G>T	c.(2527-2529)GGA>TGA	p.G843*	MYO5C_uc010uga.1_Intron|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	843	IQ 4.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		GCCAGGAATCCTCGGCTGTAG	0.547													1	0	1.44639e-49	0.00361	1.67251e-49	93	100										A	52534274	C	A	52534274	4	1	77	1	0	0	0	0	0	1	0	0	10080	690	24	4	2789	4	MYO5C	15	52534274	Nonsense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	17449807	52534274	49997118	280	23309										
PIGB	9488	broad.mit.edu	37	chr15	55632964	55632964	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tattcatggctgctatctagCaccaaagagataccggatac	8	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:55632964C>T	uc002act.2	+	8	1317	c.1001C>T	c.(1000-1002)GCA>GTA	p.A334V	PIGB_uc010ugg.1_Missense_Mutation_p.A139V	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	334	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		TGCTATCTAGCACCAAAGAGA	0.378													0	0	0	0.000602	0	4	5										T	55632964	C	T	55632964	3	4	77	1	0	0	0	0	1	0	0	0	11885	710	25	2	1031	2	PIGB	15	55632964	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3098690	55632964	46898428	281	23310										
MYO1E	4643	broad.mit.edu	37	chr15	59548521	59548521	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttctctctgtcaatgatcatGtttctgtacatattatctgc	5	9	6	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:59548521G>A	uc002aga.2	-	4	666	c.294C>T	c.(292-294)AAC>AAT	p.N98N		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	98	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		CAATGATCATGTTTCTGTACA	0.343													0	0	0	0.001855	0	10	26										A	59548521	G	A	59548521	2	1	77	1	0	0	0	0	0	0	0	1	10072	1368	48	2		2	MYO1E	15	59548521	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3915557	59548521	42982871	282	23311										
PPCDC	60490	broad.mit.edu	37	chr15	75336745	75336745	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agatatggaagagccgctctGacccagttctgcacattgac	10	11	2	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:75336745G>A	uc002azo.2	+	4	363	c.250G>A	c.(250-252)GAC>AAC	p.D84N		NM_021823	NP_068595	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase	84					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenoylcysteine decarboxylase activity				0						GAGCCGCTCTGACCCAGTTCT	0.587													0	0	0	0.00361	0	44	36										A	75336745	G	A	75336745	3	1	77	1	0	0	0	0	1	0	0	0	12304	1290	45	1	260	1	PPCDC	15	75336745	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	15788224	75336745	27194647	283	23312										
MTHFS	10588	broad.mit.edu	37	chr15	80137594	80137594	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taaaggacttcatctaccttCatgtcgttttcattcactgg	6	10	5	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:80137594C>A	uc002bex.3	-	3	610	c.570G>T	c.(568-570)ATG>ATT	p.M190I	MTHFS_uc002bey.2_RNA	NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	190					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		CATCTACCTTCATGTCGTTTT	0.428													1	0	1.33987e-11	0.008291	1.44061e-11	9	50										A	80137594	C	A	80137594	3	1	77	1	0	0	0	0	1	0	0	0	9932	826	29	3	45	3	MTHFS	15	80137594	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	4800849	80137594	22393798	284	23313										
ARNT2	9915	broad.mit.edu	37	chr15	80872758	80872758	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttcctcttttctagctcttcAgtggttcatgtgcctggagt	9	10	5	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:80872758A>G	uc002bfr.2	+	16	1786	c.1620A>G	c.(1618-1620)TCA>TCG	p.S540S	ARNT2_uc010unm.1_Silent_p.S529S|ARNT2_uc002bfs.2_Silent_p.S529S	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	540					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			CTAGCTCTTCAGTGGTTCATG	0.512													0	0	0	0.00632	0	23	92										G	80872758	A	G	80872758	2	3	77	1	0	0	0	0	0	0	0	1	966	175	7	5		5	ARNT2	15	80872758	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	735164	80872758	21658634	285	23314										
SV2B	9899	broad.mit.edu	37	chr15	91769791	91769791	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	accagtacgagaccatcatgGatgagtgtggccatggccgc	13	11	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:91769791G>T	uc002bqv.2	+	1	689	c.298G>T	c.(298-300)GAT>TAT	p.D100Y	SV2B_uc002bqt.2_Missense_Mutation_p.D100Y|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	100	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GACCATCATGGATGAGTGTGG	0.587													1	0	4.36969e-10	0.001855	4.61723e-10	14	33										T	91769791	G	T	91769791	3	4	77	1	0	0	0	0	1	0	0	0	15415	1174	41	3	300	3	SV2B	15	91769791	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	10897033	91769791	10761601	286	23315										
ZNF598	90850	broad.mit.edu	37	chr16	2049883	2049885	+	In_Frame_Del	DEL	TCC	TCC	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cctgcagggccgggccgccgTcctcctcctcctcctgtgtg							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:2049883_2049885delTCC	uc002cof.1	-	11	1680_1682	c.1665_1667delGGA	c.(1663-1668)GAGGAC>GAC	p.E555del	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	555						intracellular	zinc ion binding			lung(1)|breast(1)	2						CGGGCCGCCGTCCTCCTCCTCCT	0.709																		4	6	---	---								-	2049885	TCC	-	2049883	7	5	77	1	0	1	0	1	0	0	0	0	18025	1667	58	0	1063	0	ZNF598	16	2049883	In_Frame_Del	DEL	TCC	TCGA-FD-A3N5-01A-11D-A21A-08		2049883	88304870	287	23316										
ABCA3	21	broad.mit.edu	37	chr16	2369649	2369651	+	In_Frame_Del	DEL	AGC	AGC	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcgcggtgtaggtgaagctgAgcagcagcagcaggggcagc					rs145342500		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:2369649_2369651delAGC	uc002cpy.1	-	8	1516_1518	c.804_806delGCT	c.(802-807)CTGCTC>CTC	p.268_269LL>L	ABCA3_uc010bsk.1_In_Frame_Del_p.268_269LL>L|ABCA3_uc010bsl.1_In_Frame_Del_p.268_269LL>L	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	268_269	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GGTGAAGCTGAGCAGCAGCAGCA	0.611																		9	367	---	---								-	2369651	AGC	-	2369649	7	5	77	1	0	1	0	1	0	0	0	0	33	304	11	0	4412	0	ABCA3	16	2369649	In_Frame_Del	DEL	AGC	TCGA-FD-A3N5-01A-11D-A21A-08	319766	2369649	87985104	288	23317										
IL32	9235	broad.mit.edu	37	chr16	3119252	3119252	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tccagagtttctgctgctctCtgtcagagctcttcatgtcc	8	13	5	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:3119252C>T	uc002cto.2	+	6	812	c.601C>T	c.(601-603)CTG>TTG	p.L201L	IL32_uc002ctk.2_Intron|IL32_uc010uwp.1_Silent_p.L135L|IL32_uc010btb.2_Silent_p.L145L|IL32_uc002ctl.2_Silent_p.L155L|IL32_uc002ctm.2_Silent_p.L155L|IL32_uc002ctn.2_Silent_p.L155L|IL32_uc002cts.3_Silent_p.L155L|IL32_uc002ctp.2_Silent_p.L135L|IL32_uc002ctq.2_Silent_p.L201L|IL32_uc002ctr.2_Silent_p.L135L|IL32_uc002ctt.2_Silent_p.L155L|IL32_uc010uwr.1_Silent_p.L115L|IL32_uc002ctu.2_Silent_p.L146L	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	201					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CTGCTGCTCTCTGTCAGAGCT	0.592													0	0	0	0.000978	0	11	62										T	3119252	C	T	3119252	2	4	77	1	0	0	0	0	0	0	0	1	7692	912	32	1		1	IL32	16	3119252	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	749603	3119252	87235501	289	23318										
CREBBP	1387	broad.mit.edu	37	chr16	3900861	3900861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcctgggttgatactagagcCgctgcctcctcgtagaagct	11	12	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:3900861C>T	uc002cvv.2	-	2	439	c.235G>A	c.(235-237)GGC>AGC	p.G79S	CREBBP_uc002cvw.2_Missense_Mutation_p.G79S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	79					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ATACTAGAGCCGCTGCCTCCT	0.542			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.002299	0	21	62										T	3900861	C	T	3900861	3	4	77	1	0	0	0	0	1	0	0	0	3861	652	23	2	7213	2	CREBBP	16	3900861	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	781609	3900861	86453892	290	23319										
MYH11	4629	broad.mit.edu	37	chr16	15818266	15818266	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cttcttcttcgagtcggagaGctacaaggacagcgtccagg	12	11	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:15818266G>C	uc002ddy.2	-	31	4224	c.4117C>G	c.(4117-4119)CTC>GTC	p.L1373V	MYH11_uc002ddv.2_Missense_Mutation_p.L1380V|MYH11_uc002ddw.2_Missense_Mutation_p.L1373V|MYH11_uc002ddx.2_Missense_Mutation_p.L1380V|MYH11_uc010bvg.2_Missense_Mutation_p.L1205V|NDE1_uc010uzy.1_3'UTR|NDE1_uc002dds.2_3'UTR|MYH11_uc010bvh.2_Missense_Mutation_p.L79V|NDE1_uc002ddz.1_RNA	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1373	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GAGTCGGAGAGCTACAAGGAC	0.582			T	CBFB	AML								0	0	0	0.004007	0	14	45										C	15818266	G	C	15818266	3	2	77	1	0	0	0	0	1	0	0	0	10031	985	34	4	1880	4	MYH11	16	15818266	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	11917405	15818266	74536487	291	23320										
IL27	246778	broad.mit.edu	37	chr16	28518125	28518126	+	Frame_Shift_Ins	INS	-	-	C													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccaaggtcgcctgccgtctINSggcccatggcggggcccagc							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:28518125_28518126insC	uc002dqc.2	-	1	30_31	c.7_8insG	c.(7-9)CAGfs	p.Q3fs	uc010vct.1_Intron	NM_145659	NP_663634	Q8NEV9	IL27A_HUMAN	interleukin 27 precursor	3					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding				0						GCCTGCCGTCTGGCCCATGGCG	0.629																		40	119	---	---								C	28518126	-	C	28518125	7	5	77	1	0	1	1	0	0	0	0	0	7680	1580	55	0	743	0	IL27	16	28518125	Frame_Shift_Ins	INS	-	TCGA-FD-A3N5-01A-11D-A21A-08	12699859	28518125	61836628	292	23321										
SEPT1	1731	broad.mit.edu	37	chr16	30390387	30390388	+	Frame_Shift_Ins	INS	-	-	AGCG													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccgggccaggctctgtaggcINSagcgggcccggtagccctcg							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:30390387_30390388insAGCG	uc002dxy.2	-	10	1064_1065	c.877_878insCGCT	c.(877-879)TGCfs	p.C293fs	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Frame_Shift_Ins_p.C118fs	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	293					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			GCTCTGTAGGCAGCGGGCCCGG	0.658																		65	108	---	---								AGCG	30390388	-	AGCG	30390387	7	5	77	1	0	1	1	0	0	0	0	0	14059	710	25	0	237	0	SEPT1	16	30390387	Frame_Shift_Ins	INS	-	TCGA-FD-A3N5-01A-11D-A21A-08	1872262	30390387	59964366	293	23322										
RPGRIP1L	23322	broad.mit.edu	37	chr16	53698905	53698905	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taacttccattgctcttcatGggcagcactgaaggcactgc	9	12	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:53698905G>C	uc002ehp.2	-	10	1184	c.1120C>G	c.(1120-1122)CAT>GAT	p.H374D	RPGRIP1L_uc002eho.3_Missense_Mutation_p.H374D|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.H374D|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.H374D|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.H374D	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	374	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TGCTCTTCATGGGCAGCACTG	0.438													0	0	0	0.006122	0	15	17										C	53698905	G	C	53698905	3	2	77	1	0	0	0	0	1	0	0	0	13550	1348	47	4	2899	4	RPGRIP1L	16	53698905	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	23308518	53698905	36655848	294	23323										
GPR56	9289	broad.mit.edu	37	chr16	57685350	57685350	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aaccgacatgctgggagattAcatcttctctatggcaagcg	10	10	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:57685350A>T	uc002emb.2	+	4	595	c.303A>T	c.(301-303)TTA>TTT	p.L101F	GPR56_uc002elz.1_Intron|GPR56_uc002ema.1_5'UTR|GPR56_uc002emc.2_Missense_Mutation_p.L101F|GPR56_uc002emf.2_Missense_Mutation_p.L101F|GPR56_uc010vhs.1_Missense_Mutation_p.L101F|GPR56_uc002emd.2_Missense_Mutation_p.L101F|GPR56_uc002eme.2_Missense_Mutation_p.L101F|GPR56_uc010vht.1_Missense_Mutation_p.L106F|GPR56_uc002emg.3_Missense_Mutation_p.L101F|GPR56_uc010vhu.1_5'UTR	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	101	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						CTGGGAGATTACATCTTCTCT	0.602													0	0	0	0.007413	0	19	60										T	57685350	A	T	57685350	3	4	77	1	0	0	0	0	1	0	0	0	6700	388	14	5	324	5	GPR56	16	57685350	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	3986445	57685350	32669403	295	23324										
GPR97	222487	broad.mit.edu	37	chr16	57719645	57719645	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttcctctttggcatggtggtCctggccctggtggtctggaa	14	10	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:57719645C>T	uc002emh.2	+	11	1450	c.1347C>T	c.(1345-1347)GTC>GTT	p.V449V	GPR97_uc010vhv.1_Silent_p.V329V|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Silent_p.V57V	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	449	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GCATGGTGGTCCTGGCCCTGG	0.592													0	0	0	0.010504	0	21	80										T	57719645	C	T	57719645	2	4	77	1	0	0	0	0	0	0	0	1	6720	842	30	1		1	GPR97	16	57719645	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	34295	57719645	32635108	296	23325										
KATNB1	10300	broad.mit.edu	37	chr16	57786831	57786831	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccgacctggccatctgcaaTgaccagttggtgagagagcc	13	12	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:57786831T>C	uc002eml.1	+	10	1220	c.846T>C	c.(844-846)AAT>AAC	p.N282N		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	282	Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CCATCTGCAATGACCAGTTGG	0.667													0	0	0	0.007291	0	21	58										C	57786831	T	C	57786831	2	2	77	1	0	0	0	0	0	0	0	1	7987	1461	51	5		5	KATNB1	16	57786831	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	67186	57786831	32567922	297	23326										
NDRG4	65009	broad.mit.edu	37	chr16	58538110	58538110	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaggacatgcaggagatcacCaagcactttgtggtgtgtca	13	8	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:58538110C>T	uc002eno.2	+	3	286	c.180C>T	c.(178-180)ACC>ACT	p.T60T	NDRG4_uc002enk.2_Silent_p.T92T|NDRG4_uc002enm.2_Silent_p.T112T|NDRG4_uc010vif.1_Silent_p.T92T|NDRG4_uc010cdk.2_Silent_p.T78T|NDRG4_uc010vig.1_Silent_p.T90T|NDRG4_uc010vih.1_Silent_p.T5T|NDRG4_uc010vii.1_Silent_p.T78T|NDRG4_uc002enp.2_Silent_p.T60T|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	60					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						AGGAGATCACCAAGCACTTTG	0.572													0	0	0	0.00874	0	39	179										T	58538110	C	T	58538110	2	4	77	1	0	0	0	0	0	0	0	1	10254	581	21	2		2	NDRG4	16	58538110	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	751279	58538110	31816643	298	23327										
CBFB	865	broad.mit.edu	37	chr16	67116228	67116228	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggaggtgagagtttcacagcTgctggcagtaactggttagt	15	6	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:67116228T>A	uc002era.2	+	5	773	c.512T>A	c.(511-513)CTG>CAG	p.L171Q	CBFB_uc002erb.2_Intron|CBFB_uc010vja.1_Intron	NM_001755	NP_001746	Q13951	PEBB_HUMAN	core-binding factor, beta subunit isoform 2	171					transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00189)|Epithelial(162;0.00755)|all cancers(182;0.066)		GTTTCACAGCTGCTGGCAGTA	0.428			T	MYH11	AML								0	0	0	0.00361	0	38	83										A	67116228	T	A	67116228	3	1	77	1	0	0	0	0	1	0	0	0	2699	1580	55	5	530	5	CBFB	16	67116228	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	8578118	67116228	23238525	299	23328										
VPS4A	27183	broad.mit.edu	37	chr16	69352762	69352762	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaagcccaacatacggtggaAcgacgtggccgggctggagg	17	10	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:69352762A>G	uc002eww.2	+	5	508	c.380A>G	c.(379-381)AAC>AGC	p.N127S		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting factor 4A	127					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)				ATACGGTGGAACGACGTGGCC	0.507													0	0	0	0.00361	0	72	239										G	69352762	A	G	69352762	3	3	77	1	0	0	0	0	1	0	0	0	17209	43	2	5	398	5	VPS4A	16	69352762	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	2236534	69352762	21001991	300	23329										
ZNF23	7571	broad.mit.edu	37	chr16	71483261	71483261	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	acactccacacatttgaaggGtttctccccactgtgaagtc	7	13	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:71483261G>A	uc002faf.2	-	6	1481	c.667C>T	c.(667-669)CCC>TCC	p.P223S	ZNF23_uc002fad.2_Missense_Mutation_p.P165S|ZNF23_uc002fae.2_Missense_Mutation_p.P165S|ZNF23_uc010vmf.1_Missense_Mutation_p.P165S|ZNF23_uc002fag.2_Missense_Mutation_p.P165S|ZNF23_uc002fah.2_Missense_Mutation_p.P223S|ZNF23_uc002fai.2_Missense_Mutation_p.P262S	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CATTTGAAGGGTTTCTCCCCA	0.438													0	0	0	0.00361	0	40	32										A	71483261	G	A	71483261	3	1	77	1	0	0	0	0	1	0	0	0	17780	1261	44	2	1268	2	ZNF23	16	71483261	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2130499	71483261	18871492	301	23330										
CHST4	10164	broad.mit.edu	37	chr16	71571354	71571354	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agccagctggagatctacaaGaccatccagtccttgcccaa	8	14	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:71571354G>A	uc002fan.2	+	2	955	c.774G>A	c.(772-774)AAG>AAA	p.K258K	CHST4_uc002fao.2_Silent_p.K258K	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	258	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGATCTACAAGACCATCCAGT	0.557											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	9	63										A	71571354	G	A	71571354	2	1	77	1	0	0	0	0	0	0	0	1	3406	933	33	1		1	CHST4	16	71571354	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	88093	71571354	18783399	302	23331										
PHLPP2	23035	broad.mit.edu	37	chr16	71706188	71706188	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gagagatccaagaaagtgagCaggctgggtactggatagac	15	6	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:71706188C>A	uc002fax.2	-	9	1515	c.1509G>T	c.(1507-1509)CTG>CTT	p.L503L	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Silent_p.L503L	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	503	LRR 12.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						AGAAAGTGAGCAGGCTGGGTA	0.438													1	0	2.48551e-13	0.00499	2.69945e-13	11	26										A	71706188	C	A	71706188	2	1	77	1	0	0	0	0	0	0	0	1	11855	697	25	4		4	PHLPP2	16	71706188	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	134834	71706188	18648565	303	23332										
ASPA	443	broad.mit.edu	37	chr17	3379514	3379514	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttgctatctttggaggaaccCatgggaatgagctaaccgga	12	8	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:3379514C>G	uc010ckg.2	+	2	152	c.61C>G	c.(61-63)CAT>GAT	p.H21D	SPATA22_uc010vrg.1_Intron|ASPA_uc002fvq.2_Missense_Mutation_p.H21D	NM_001128085	NP_001121557	P45381	ACY2_HUMAN	aspartoacylase	21		Zinc.	H -> P (in CAND).		aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TGGAGGAACCCATGGGAATGA	0.398													0	0	0	0.00874	0	34	29										G	3379514	C	G	3379514	3	3	77	1	0	0	0	0	1	0	0	0	1050	594	21	4	63	4	ASPA	17	3379514	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		3379514	77815696	304	23333										
TP53	7157	broad.mit.edu	37	chr17	7578208	7578208	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	catagggcaccaccacactaTgtcgaaaagtgtttctgtca	8	11	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:7578208T>C	uc002gim.2	-	6	835	c.641A>G	c.(640-642)CAT>CGT	p.H214R	TP53_uc002gig.1_Missense_Mutation_p.H214R|TP53_uc002gih.2_Missense_Mutation_p.H214R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H82R|TP53_uc010cng.1_Missense_Mutation_p.H82R|TP53_uc002gii.1_Missense_Mutation_p.H82R|TP53_uc010cnh.1_Missense_Mutation_p.H214R|TP53_uc010cni.1_Missense_Mutation_p.H214R|TP53_uc002gij.2_Missense_Mutation_p.H214R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H121R|TP53_uc002gio.2_Missense_Mutation_p.H82R|TP53_uc010vug.1_Missense_Mutation_p.H175R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	214	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> Y (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H214R(45)|p.0?(7)|p.H214Y(4)|p.H214Q(4)|p.H214D(3)|p.H214fs*5(2)|p.H214fs*33(2)|p.D208fs*1(1)|p.K164_P219del(1)|p.H214H(1)|p.H214fs*7(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213fs*32(1)|p.T211_S215delTFRHS(1)|p.H214_S215insX(1)|p.R209fs*6(1)|p.D208_V216delDRNTFRHSV(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACCACACTATGTCGAAAAGT	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	42	13										C	7578208	T	C	7578208	3	2	77	1	0	0	0	0	1	0	0	0	16378	1464	51	5	653	5	TP53	17	7578208	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	4198694	7578208	73617002	305	23334										
CHD3	1107	broad.mit.edu	37	chr17	7788214	7788214	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gaggaagaagagggcgacgaGgaggaggaggaggaggtgga	24	2	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:7788214G>C	uc002gjd.2	+	1	92	c.90G>C	c.(88-90)GAG>GAC	p.E30D		NM_001005271	NP_001005271	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	445	Poly-Glu.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				agggcgacgaggaggaggagg	0.299													0	0	0	0.004672	0	2	3										C	7788214	G	C	7788214	3	2	77	1	0	0	0	0	1	0	0	0	3326	991	35	4	92	4	CHD3	17	7788214	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	210006	7788214	73406996	306	23335										
TOP2A	7153	broad.mit.edu	37	chr17	38556598	38556598	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atggtattccctatagtctgTtatgagaggaggtgtcttct	11	6	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:38556598T>C	uc002huq.2	-	23	2989	c.2863A>G	c.(2863-2865)ACA>GCA	p.T955A		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	955					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CTATAGTCTGTTATGAGAGGA	0.378													0	0	0	0.001855	0	11	15										C	38556598	T	C	38556598	3	2	77	1	0	0	0	0	1	0	0	0	16362	1725	60	5	1784	5	TOP2A	17	38556598	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	30768384	38556598	42638612	307	23336										
KRT16	3868	broad.mit.edu	37	chr17	39766722	39766722	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggccagctgctcctccacacTgccaatcagtccctggatct	8	17	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:39766722T>C	uc002hxg.3	-	6	1280	c.1141A>G	c.(1141-1143)AGT>GGT	p.S381G	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	381	Rod.|Coil 2.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				TCCTCCACACTGCCAATCAGT	0.577													0	0	0	0.00361	0	59	126										C	39766722	T	C	39766722	3	2	77	1	0	0	0	0	1	0	0	0	8453	1580	55	5	292	5	KRT16	17	39766722	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1210124	39766722	41428488	308	23337										
JUP	3728	broad.mit.edu	37	chr17	39923802	39923802	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggttgtgcagcgtggtgatGgcatagaacaggaccgactc	15	8	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:39923802G>A	uc002hxq.2	-	5	1015	c.738C>T	c.(736-738)GCC>GCT	p.A246A	JUP_uc010wfs.1_Silent_p.A246A|JUP_uc002hxr.2_Silent_p.A246A|JUP_uc002hxs.2_Silent_p.A246A	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	246	ARM 2.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCGTGGTGATGGCATAGAACA	0.637													0	0	0	0.00333	0	24	85										A	39923802	G	A	39923802	2	1	77	1	0	0	0	0	0	0	0	1	7972	1335	47	2		2	JUP	17	39923802	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	157080	39923802	41271408	309	23338										
DHX8	1659	broad.mit.edu	37	chr17	41598153	41598153	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctggagccaatgctatgcaAaatgctcatcatgtctgtgc	9	10	4	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:41598153A>G	uc002idu.1	+	20	3045	c.2972A>G	c.(2971-2973)AAA>AGA	p.K991R	DHX8_uc010wig.1_Missense_Mutation_p.K991R	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	991						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ATGCTATGCAAAATGCTCATC	0.478											OREG0024435	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	19	14										G	41598153	A	G	41598153	3	3	77	1	0	0	0	0	1	0	0	0	4515	14	1	5	3050	5	DHX8	17	41598153	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	1674351	41598153	39597057	310	23339										
ITGA2B	3674	broad.mit.edu	37	chr17	42455070	42455071	+	Missense_Mutation	DNP	GC	GC	TA													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gacccagcagcctcacctggGcgttcttcttcatggggttg					rs146445219		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:42455070_42455071GC>TA	uc002igt.1	-	21	2214_2215	c.2182_2183GC>TA	c.(2182-2184)GCC>TAC	p.A728Y	ITGA2B_uc002igu.1_Missense_Mutation_p.A209Y	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	728	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CCTCACCTGGGCGTTCTTCTTC	0.47													0	0	0	0.004672	0	12	49										TA	42455071	GC	TA	42455070	3	4	77	1	0	0	0	0	1	0	0	0	7876	1203	42	4	976	4	ITGA2B	17	42455070	Missense_Mutation	DNP	GC	TCGA-FD-A3N5-01A-11D-A21A-08	856917	42455070	38740140	311	23340										
AKAP1	8165	broad.mit.edu	37	chr17	55195741	55195741	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cttttccttttcctcctgaaGacgatgaccagttttcaccg	6	13	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:55195741G>T	uc002iux.2	+	9	2732	c.2501_splice	c.e9-1	p.D834_splice	AKAP1_uc010wnl.1_Splice_Site_p.D834_splice|AKAP1_uc010dcm.2_Splice_Site_p.D834_splice	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor						blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					TCCTCCTGAAGACGATGACCA	0.532													1	0	5.71845e-15	0.005524	6.2582e-15	32	37										T	55195741	G	T	55195741	5	4	77	1	0	0	0	0	0	0	1	0	445	956	33	3	2530	3	AKAP1	17	55195741	Splice_Site	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	12740671	55195741	25999469	312	23341										
LPO	4025	broad.mit.edu	37	chr17	56327935	56327935	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtagcgagtactccaaagccCagtgtgatgagtactgtatc	11	9	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:56327935C>G	uc002ivt.2	+	7	1049	c.733C>G	c.(733-735)CAG>GAG	p.Q245E	LPO_uc010dco.2_Missense_Mutation_p.Q245E|LPO_uc010wnr.1_Missense_Mutation_p.Q162E|LPO_uc010wns.1_Missense_Mutation_p.Q186E|LPO_uc010dcp.2_Missense_Mutation_p.Q162E|LPO_uc010dcq.2_Intron|LPO_uc010dcr.2_5'Flank	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	245					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						CTCCAAAGCCCAGTGTGATGA	0.557													0	0	0	0.002522	0	37	27										G	56327935	C	G	56327935	3	3	77	1	0	0	0	0	1	0	0	0	8922	595	21	4	755	4	LPO	17	56327935	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1132194	56327935	24867275	313	23342										
RAD51C	5889	broad.mit.edu	37	chr17	56780655	56780655	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagagttactggcacaagttTatcttcttccagatttcctt	6	10	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:56780655T>C	uc002iwu.2	+	4	712	c.670T>C	c.(670-672)TAT>CAT	p.Y224H	RAD51C_uc010woa.1_Missense_Mutation_p.Y224H|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	224					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCACAAGTTTATCTTCTTCC	0.348								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.001368	0	10	27										C	56780655	T	C	56780655	3	2	77	1	0	0	0	0	1	0	0	0	12988	1754	61	5	688	5	RAD51C	17	56780655	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	452720	56780655	24414555	314	23343										
RNFT1	51136	broad.mit.edu	37	chr17	58040588	58040588	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agttggctacgattggcttgCatggcccttaaatacttttt	9	8	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:58040588C>T	uc002iya.2	-	2	207	c.114G>A	c.(112-114)ATG>ATA	p.M38I	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.M38I|RNFT1_uc002iyd.3_Missense_Mutation_p.M38I	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	38						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			GATTGGCTTGCATGGCCCTTA	0.453													0	0	0	0.001368	0	11	40										T	58040588	C	T	58040588	3	4	77	1	0	0	0	0	1	0	0	0	13501	710	25	2	1225	2	RNFT1	17	58040588	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1259933	58040588	23154622	315	23344										
SCN4A	6329	broad.mit.edu	37	chr17	62021113	62021113	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagaggtctgtacctggggcCggggaattggcttctgaggc	17	9	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:62021113C>T	uc002jds.1	-	22	4087	c.4010G>A	c.(4009-4011)CGG>CAG	p.R1337Q		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1337					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TACCTGGGGCCGGGGAATTGG	0.353													0	0	0	0.001168	0	4	13										T	62021113	C	T	62021113	3	4	77	1	0	0	0	0	1	0	0	0	13920	652	23	2	1512	2	SCN4A	17	62021113	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	3980525	62021113	19174097	316	23345										
DDX5	1655	broad.mit.edu	37	chr17	62499626	62499626	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cttcaagcgacatgctctacAatattcagcagctacttgct	6	12	3	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:62499626A>C	uc002jek.2	-	6	818	c.571T>G	c.(571-573)TGT>GGT	p.C191G	DDX5_uc010deh.2_Missense_Mutation_p.C191G|DDX5_uc002jej.2_Missense_Mutation_p.C86G|DDX5_uc010wqa.1_Missense_Mutation_p.C112G|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	191	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CATGCTCTACAATATTCAGCA	0.463			T	ETV4	prostate								0	0	0	0.00278	0	18	45										C	62499626	A	C	62499626	3	2	77	1	0	0	0	0	1	0	0	0	4367	130	5	5	1305	5	DDX5	17	62499626	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	478513	62499626	18695584	317	23346										
PSMD12	5718	broad.mit.edu	37	chr17	65337149	65337149	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tcttgttaactactagatttGagagaaaggcttcggactcc	9	8	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:65337149G>A	uc002jfy.2	-	11	1267	c.1181C>T	c.(1180-1182)TCA>TTA	p.S394L	PSMD12_uc002jga.2_Missense_Mutation_p.S374L|PSMD12_uc002jfz.2_Missense_Mutation_p.S335L	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	394	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					TACTAGATTTGAGAGAAAGGC	0.338													0	0	0	0.006214	0	7	18										A	65337149	G	A	65337149	3	1	77	1	0	0	0	0	1	0	0	0	12695	1294	45	1	193	1	PSMD12	17	65337149	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2837523	65337149	15858061	318	23347										
KCTD2	23510	broad.mit.edu	37	chr17	73043506	73043506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggctgccgccgtcgcgcagcCgctggagccgggtcccggac	17	17	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:73043506C>T	uc002jmp.2	+	1	228	c.161C>T	c.(160-162)CCG>CTG	p.P54L	KCTD2_uc010dfy.1_Intron|KCTD2_uc010dfz.2_Intron|ATP5H_uc002jmn.1_5'Flank|ATP5H_uc002jmo.1_5'Flank|KCTD2_uc002jmq.2_Intron	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	54				P -> R (in Ref. 1; BAA11493).		voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					gtcgcgcagccgctggagccg	0.149													0	0	0	0.00308	0	8	5										T	73043506	C	T	73043506	3	4	77	1	0	0	0	0	1	0	0	0	8107	652	23	2	163	2	KCTD2	17	73043506	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	7706357	73043506	8151704	319	23348										
LLGL2	3993	broad.mit.edu	37	chr17	73569202	73569202	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cacttcggcagtcgtcgagcCgaggactacggggagcacca	14	13	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:73569202C>T	uc002joh.2	+	20	2722	c.2568C>T	c.(2566-2568)GCC>GCT	p.A856A	LLGL2_uc002joi.2_Silent_p.A856A|LLGL2_uc010dgg.1_Silent_p.A856A|LLGL2_uc002joj.2_Silent_p.A845A|LLGL2_uc010wsd.1_Silent_p.A483A	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	856	WD 13.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GTCGTCGAGCCGAGGACTACG	0.657													0	0	0	0.00361	0	64	82										T	73569202	C	T	73569202	2	4	77	1	0	0	0	0	0	0	0	1	8834	639	23	2		2	LLGL2	17	73569202	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	525696	73569202	7626008	320	23349										
QRICH2	84074	broad.mit.edu	37	chr17	74283886	74283886	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctggggcattttacctgagGacacccagctgcaatctcag	11	12	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:74283886G>A	uc002jrd.1	-	6	3573	c.3393C>T	c.(3391-3393)GTC>GTT	p.V1131V	QRICH2_uc010wsz.1_Silent_p.V1057V|QRICH2_uc010dgw.1_5'UTR	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1131	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TTTACCTGAGGACACCCAGCT	0.557													0	0	0	0.00245	0	12	49										A	74283886	G	A	74283886	2	1	77	1	0	0	0	0	0	0	0	1	12880	1161	41	1		1	QRICH2	17	74283886	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	714684	74283886	6911324	321	23350										
MFSD11	79157	broad.mit.edu	37	chr17	74737129	74737129	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cctcaactctctatgtttgcCagtggtttattttacaggta	7	9	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:74737129C>G	uc002jta.2	+	4	1216	c.243C>G	c.(241-243)GCC>GCG	p.A81A	MFSD11_uc002jtb.2_Silent_p.A81A|MFSD11_uc010dha.2_Silent_p.A81A|MFSD11_uc002jtc.2_Silent_p.A81A|MFSD11_uc002jtd.3_Silent_p.A81A|MFSD11_uc010dhb.2_Silent_p.A81A|MFSD11_uc002jte.2_Silent_p.A81A	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	81	Helical; (Potential).					integral to membrane				ovary(1)	1						CTATGTTTGCCAGTGGTTTAT	0.363													0	0	0	0.005443	0	26	41										G	74737129	C	G	74737129	2	3	77	1	0	0	0	0	0	0	0	1	9529	581	21	4		4	MFSD11	17	74737129	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	453243	74737129	6458081	322	23351										
NPLOC4	55666	broad.mit.edu	37	chr17	79580442	79580442	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggagcgccaaagactttgaaGcccggtggaactgacgtctc	13	11	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:79580442G>A	uc002kat.3	-	4	470	c.288C>T	c.(286-288)GGC>GGT	p.G96G	NPLOC4_uc002kau.3_Silent_p.G96G|NPLOC4_uc010wur.1_5'UTR	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	96					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGACTTTGAAGCCCGGTGGAA	0.517													0	0	0	0.004672	0	3	26										A	79580442	G	A	79580442	2	1	77	1	0	0	0	0	0	0	0	1	10586	958	34	2		2	NPLOC4	17	79580442	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4843313	79580442	1614768	323	23352										
RBBP8	5932	broad.mit.edu	37	chr18	20581688	20581688	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctactgccacaaagaaactAcacagtaagatttttttctg	5	9	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:20581688A>G	uc002ktw.2	+	15	2614	c.2283A>G	c.(2281-2283)CTA>CTG	p.L761L	RBBP8_uc002kty.2_Silent_p.L761L|RBBP8_uc002ktz.2_Silent_p.L761L|RBBP8_uc002kua.2_Silent_p.L766L|RBBP8_uc010xap.1_Silent_p.L99L	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	761					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CAAAGAAACTACACAGTAAGA	0.373								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.00308	0	8	16										G	20581688	A	G	20581688	2	3	77	1	0	0	0	0	0	0	0	1	13105	378	14	5		5	RBBP8	18	20581688	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08		20581688	57495560	324	23353										
LAMA3	3909	broad.mit.edu	37	chr18	21485588	21485588	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cacaaaagaagctaaagcaaGgtattagggggagtgggcaa	14	5	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:21485588G>T	uc002kuq.2	+	52	6804	c.6718G>T	c.(6718-6720)GAA>TAA	p.E2240*	LAMA3_uc002kur.2_Nonsense_Mutation_p.E2184*|LAMA3_uc002kus.3_Nonsense_Mutation_p.E631*|LAMA3_uc002kut.3_Nonsense_Mutation_p.E575*	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2240	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTAAAGCAAGGTATTAGGGG	0.438													1	0	0.00909568	0.009096	0.00924656	3	19										T	21485588	G	T	21485588	4	4	77	1	0	0	0	0	0	1	0	0	8607	1014	35	4	7099	4	LAMA3	18	21485588	Nonsense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	903900	21485588	56591660	325	23354										
CDH2	1000	broad.mit.edu	37	chr18	25532201	25532201	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taatcatagtcctgctcaccAccactacttgaggaattaag	6	11	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:25532201A>C	uc002kwg.2	-	16	3096	c.2637T>G	c.(2635-2637)GGT>GGG	p.G879G	CDH2_uc010xbn.1_Silent_p.G848G	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	879	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCTGCTCACCACCACTACTTG	0.507											OREG0003876	type=REGULATORY REGION|Gene=CDH2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004007	0	14	68										C	25532201	A	C	25532201	2	2	77	1	0	0	0	0	0	0	0	1	3105	146	6	5		5	CDH2	18	25532201	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	4046613	25532201	52545047	326	23355										
MAPRE2	10982	broad.mit.edu	37	chr18	32621508	32621508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tctcgggagtgcgccaatgcCtgggccgacccaaaccctgt	12	15	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:32621508C>T	uc002kyg.2	+	1	185	c.5C>T	c.(4-6)CCT>CTT	p.P2L	MAPRE2_uc010xcb.1_Intron|MAPRE2_uc010xcc.1_Intron|MAPRE2_uc002kyf.2_Missense_Mutation_p.P2L|MAPRE2_uc002kyh.2_5'UTR|MAPRE2_uc010xcd.1_5'Flank	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	2					cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						GCGCCAATGCCTGGGCCGACC	0.612													0	0	0	0.00361	0	75	83										T	32621508	C	T	32621508	3	4	77	1	0	0	0	0	1	0	0	0	9295	681	24	2	101	2	MAPRE2	18	32621508	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	7089307	32621508	45455740	327	23356										
PIK3C3	5289	broad.mit.edu	37	chr18	39637870	39637870	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aactcttccacatagactttGgatatattttgggtcgggat	9	7	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:39637870G>A	uc002lap.2	+	22	2345	c.2287G>A	c.(2287-2289)GGA>AGA	p.G763R	PIK3C3_uc010xcl.1_Missense_Mutation_p.G700R|PIK3C3_uc002laq.2_Missense_Mutation_p.G248R	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	763	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CATAGACTTTGGATATATTTT	0.418										TSP Lung(28;0.18)			0	0	0	0.000978	0	9	14										A	39637870	G	A	39637870	3	1	77	1	0	0	0	0	1	0	0	0	11912	1349	47	2	2373	2	PIK3C3	18	39637870	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	7016362	39637870	38439378	328	23357										
MAPK4	5596	broad.mit.edu	37	chr18	48255680	48255680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctcgcacagcagctccgagcGcttcctagagcagtcgcact	10	16	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:48255680G>A	uc002lev.2	+	6	2220	c.1220G>A	c.(1219-1221)CGC>CAC	p.R407H	MAPK4_uc010xdm.1_Missense_Mutation_p.R196H|MAPK4_uc010doz.2_3'UTR	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	407					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		AGCTCCGAGCGCTTCCTAGAG	0.692													0	0	0	0.00499	0	14	9										A	48255680	G	A	48255680	3	1	77	1	0	0	0	0	1	0	0	0	9280	1087	38	2	1238	2	MAPK4	18	48255680	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	8617810	48255680	29821568	329	23358										
APC2	10297	broad.mit.edu	37	chr19	1462114	1462114	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agcaactcgctggccatcatCgagagcggcggcggcatcct	13	14	1	1	rs142142534		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:1462114C>T	uc002lsr.1	+	14	1999	c.1791C>T	c.(1789-1791)ATC>ATT	p.I597I	APC2_uc002lss.1_Silent_p.I179I|APC2_uc002lst.1_Silent_p.I597I|APC2_uc002lsu.1_Silent_p.I596I|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	597	ARM 4.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCCATCATCGAGAGCGGCG	0.667													0	0	0	0.00361	0	37	128										T	1462114	C	T	1462114	2	4	77	1	0	0	0	0	0	0	0	1	764	874	31	1		1	APC2	19	1462114	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		1462114	57666869	330	23359										
ATP8B3	148229	broad.mit.edu	37	chr19	1785276	1785276	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccacgcacagggcggtccaGtacttgatgataagaatgac	12	10	0	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:1785276G>C	uc002ltw.2	-	27	3648	c.3414C>G	c.(3412-3414)TAC>TAG	p.Y1138*	ATP8B3_uc002ltv.2_Nonsense_Mutation_p.Y1101*|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1138	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCGGTCCAGTACTTGATGA	0.607													0	0	0	0.001168	0	4	27										C	1785276	G	C	1785276	4	2	77	1	0	0	0	0	0	1	0	0	1196	1024	36	4	500	4	ATP8B3	19	1785276	Nonsense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	323162	1785276	57343707	331	23360										
FZR1	51343	broad.mit.edu	37	chr19	3534500	3534500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggaacgtctttagcaaaaccCgttcgacaaaggtaaagtgg	11	8	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:3534500C>T	uc010dtk.2	+	12	1463	c.1429C>T	c.(1429-1431)CGT>TGT	p.R477C	FZR1_uc002lxt.2_Missense_Mutation_p.R477C|FZR1_uc002lxv.2_Missense_Mutation_p.R388C	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	477	WD 7.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCAAAACCCGTTCGACAAA	0.627													0	0	0	0.009096	0	4	12										T	3534500	C	T	3534500	3	4	77	1	0	0	0	0	1	0	0	0	6138	652	23	2	1475	2	FZR1	19	3534500	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1749224	3534500	55594483	332	23361										
ZBTB7A	51341	broad.mit.edu	37	chr19	4047820	4047820	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctccgctgtcacctcctccaCcggcgcccgctacattcaac	6	21	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:4047820C>T	uc002lzh.2	-	3	1760	c.1685G>A	c.(1684-1686)GGT>GAT	p.G562D	ZBTB7A_uc002lzi.2_Missense_Mutation_p.G562D	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	562	Poly-Gly.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTCCTCCACCGGCGCCCGC	0.632													0	0	0	0.001882	0	16	69										T	4047820	C	T	4047820	3	4	77	1	0	0	0	0	1	0	0	0	17550	507	18	2	73	2	ZBTB7A	19	4047820	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	513320	4047820	55081163	333	23362										
S1PR5	53637	broad.mit.edu	37	chr19	10625203	10625203	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcaggagcccgaggagcagcGacacgccccaggccgcggct	16	16	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:10625203G>A	uc002mot.1	-	2	542	c.485C>T	c.(484-486)TCG>TTG	p.S162L	S1PR5_uc002mou.1_Missense_Mutation_p.S162L	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	162	Helical; Name=4; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						GAGGAGCAGCGACACGCCCCA	0.726													0	0	0	0.000978	0	9	9										A	10625203	G	A	10625203	3	1	77	1	0	0	0	0	1	0	0	0	13797	1059	37	1	715	1	S1PR5	19	10625203	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	6577383	10625203	48503780	334	23363										
ZNF136	7695	broad.mit.edu	37	chr19	12298627	12298627	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggtgagaaaccctttgaatgTaagcgatgtggtaaagcctt	12	6	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:12298627T>C	uc002mti.2	+	4	1534	c.1434T>C	c.(1432-1434)TGT>TGC	p.C478C	ZNF136_uc010xmh.1_Silent_p.C412C	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	478	C2H2-type 13.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						CCTTTGAATGTAAGCGATGTG	0.418													0	0	0	0.008291	0	11	9										C	12298627	T	C	12298627	2	2	77	1	0	0	0	0	0	0	0	1	17723	1644	57	5		5	ZNF136	19	12298627	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1673424	12298627	46830356	335	23364										
JUNB	3726	broad.mit.edu	37	chr19	12903008	12903008	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttcgccgacggctttgtcaaAgccctggacgatctgcacaa	10	13	2	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:12903008A>C	uc002mvc.2	+	1	699	c.423A>C	c.(421-423)AAA>AAC	p.K141N	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	141						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						GCTTTGTCAAAGCCCTGGACG	0.567													0	0	0	0.001168	0	6	13										C	12903008	A	C	12903008	3	2	77	1	0	0	0	0	1	0	0	0	7970	69	3	5	425	5	JUNB	19	12903008	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	604381	12903008	46225975	336	23365										
JUNB	3726	broad.mit.edu	37	chr19	12903565	12903565	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggtggcccagctcaaacagaAggtcatgacccacgtcagca	11	13	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:12903565A>G	uc002mvc.2	+	1	1256	c.980A>G	c.(979-981)AAG>AGG	p.K327R	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	327						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						CTCAAACAGAAGGTCATGACC	0.652													0	0	0	0.004656	0	22	27										G	12903565	A	G	12903565	3	3	77	1	0	0	0	0	1	0	0	0	7970	72	3	5	982	5	JUNB	19	12903565	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	557	12903565	46225418	337	23366										
NOTCH3	4854	broad.mit.edu	37	chr19	15290217	15290223	+	Frame_Shift_Del	DEL	GGTCAAT	GGTCAAT	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcagagatagcgggccacgaGgtcaatgcatgaacccccgt							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:15290217_15290223delGGTCAAT	uc002nan.2	-	21	3488_3494	c.3412_3418delATTGACC	c.(3412-3420)ATTGACCTCfs	p.I1138fs	NOTCH3_uc002nao.1_Frame_Shift_Del_p.I1086fs	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1138_1140	Extracellular (Potential).|EGF-like 29; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CGGGCCACGAGGTCAATGCATGAACCC	0.594																		63	111	---	---								-	15290223	GGTCAAT	-	15290217	7	5	77	1	0	1	0	1	0	0	0	0	10550	1000	35	0	3599	0	NOTCH3	19	15290217	Frame_Shift_Del	DEL	GGTCAAT	TCGA-FD-A3N5-01A-11D-A21A-08	2386652	15290217	43838766	338	23367										
CPAMD8	27151	broad.mit.edu	37	chr19	17012070	17012070	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcctgacagcaggggcacctCcaggacagccatattggaag	13	12	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:17012070C>G	uc002nfb.2	-	36	4896	c.4864G>C	c.(4864-4866)GAG>CAG	p.E1622Q	CPAMD8_uc002nfd.1_Missense_Mutation_p.E87Q	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1575						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AGGGGCACCTCCAGGACAGCC	0.607													0	0	0	0.004656	0	21	25										G	17012070	C	G	17012070	3	3	77	1	0	0	0	0	1	0	0	0	3795	864	30	1	962	1	CPAMD8	19	17012070	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1721853	17012070	42116913	339	23368										
ZNF737	100129842	broad.mit.edu	37	chr19	20728292	20728292	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gcagtaaggtatgaaaaccgGctaaaggctttgccacagtc	11	9	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:20728292G>C	uc002npa.2	-	4	897	c.717C>G	c.(715-717)AGC>AGG	p.S239R		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	239					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						ATGAAAACCGGCTAAAGGCTT	0.428													0	0	0	0.000602	0	5	7										C	20728292	G	C	20728292	3	2	77	1	0	0	0	0	1	0	0	0	18123	1194	42	4	897	4	ZNF737	19	20728292	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	3716222	20728292	38400691	340	23369										
TSHZ3	57616	broad.mit.edu	37	chr19	31769651	31769651	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggagttcttctgaagtgcatCgttggtgtctgagatggtgg	16	5	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:31769651C>T	uc002nsy.3	-	2	1113	c.1048G>A	c.(1048-1050)GAT>AAT	p.D350N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	350					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGAAGTGCATCGTTGGTGTCT	0.567													0	0	0	0.009718	0	36	117										T	31769651	C	T	31769651	3	4	77	1	0	0	0	0	1	0	0	0	16622	884	31	1	2201	1	TSHZ3	19	31769651	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	11041359	31769651	27359332	341	23370										
ZFP82	284406	broad.mit.edu	37	chr19	36883875	36883875	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggcgcaatctaaaggccttgCcacattccttacatttataa	6	11	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:36883875C>T	uc002ody.1	-	5	1602	c.1367G>A	c.(1366-1368)GGC>GAC	p.G456D		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	456	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						AAAGGCCTTGCCACATTCCTT	0.418													0	0	0	0.001855	0	14	9										T	36883875	C	T	36883875	3	4	77	1	0	0	0	0	1	0	0	0	17650	739	26	2	235	2	ZFP82	19	36883875	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	5114224	36883875	22245108	342	23371										
AXL	558	broad.mit.edu	37	chr19	41765721	41765721	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggtccatcctgctggacgctAtgtcctctgcccttccacaa	8	16	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:41765721A>G	uc010ehj.2	+	20	2787	c.2597A>G	c.(2596-2598)TAT>TGT	p.Y866C	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_5'Flank|HNRNPUL1_uc002oqa.3_5'Flank|AXL_uc010ehk.2_Missense_Mutation_p.Y857C|HNRNPUL1_uc010ehl.1_5'Flank	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	866	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GCTGGACGCTATGTCCTCTGC	0.652													0	0	0	0.00361	0	61	59										G	41765721	A	G	41765721	3	3	77	1	0	0	0	0	1	0	0	0	1238	449	16	5	2675	5	AXL	19	41765721	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	4881846	41765721	17363262	343	23372										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41808694	41808694	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggccgcaaggctgggccaccCcctgaaaagcgctttgacaa	12	14	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:41808694C>T	uc002oqb.3	+	12	2101	c.1812C>T	c.(1810-1812)CCC>CCT	p.P604P	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.P504P|HNRNPUL1_uc002oqa.3_Silent_p.P504P|HNRNPUL1_uc010ehm.2_Silent_p.P604P|HNRNPUL1_uc002oqc.3_Silent_p.P490P|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.P504P|HNRNPUL1_uc010ehn.2_Silent_p.P504P|HNRNPUL1_uc010eho.2_Silent_p.P504P|HNRNPUL1_uc010xvy.1_Silent_p.P504P|HNRNPUL1_uc010ehp.2_Silent_p.P460P|HNRNPUL1_uc002oqf.3_Silent_p.P128P	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	604	Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CTGGGCCACCCCCTGAAAAGC	0.627													0	0	0	0.008871	0	18	55										T	41808694	C	T	41808694	2	4	77	1	0	0	0	0	0	0	0	1	7274	610	22	2		2	HNRNPUL1	19	41808694	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	42973	41808694	17320289	344	23373										
ARHGEF1	9138	broad.mit.edu	37	chr19	42402702	42402702	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gacaccctgcacagcctgccCaagagccaggtgaagcggca	12	15	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:42402702C>G	uc002orx.2	+	14	1342	c.1233C>G	c.(1231-1233)CCC>CCG	p.P411P	ARHGEF1_uc002ory.2_Silent_p.P378P|ARHGEF1_uc002orz.2_Silent_p.P249P|ARHGEF1_uc002osa.2_Silent_p.P426P|ARHGEF1_uc002osb.2_Silent_p.P393P|ARHGEF1_uc002osc.2_Silent_p.P165P|ARHGEF1_uc002osd.2_Silent_p.P70P	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	411					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACAGCCTGCCCAAGAGCCAGG	0.652													0	0	0	0.004482	0	6	16										G	42402702	C	G	42402702	2	3	77	1	0	0	0	0	0	0	0	1	893	581	21	4		4	ARHGEF1	19	42402702	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	594008	42402702	16726281	345	23374										
ZNF233	353355	broad.mit.edu	37	chr19	44777421	44777421	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	taggtgtcagcaaattgatgTaaaaaataagctctgtaaat	8	4	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:44777421T>C	uc002oyz.1	+	5	735	c.608T>C	c.(607-609)GTA>GCA	p.V203A	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.V18A	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				CAAATTGATGTAAAAAATAAG	0.378													0	0	0	0.00308	0	7	9										C	44777421	T	C	44777421	3	2	77	1	0	0	0	0	1	0	0	0	17783	1638	57	5	622	5	ZNF233	19	44777421	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2374719	44777421	14351562	346	23375										
ERCC2	2068	broad.mit.edu	37	chr19	45867687	45867687	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tggcgcccccctcaccaatgTtgtgggcctcgtcgaagacc	11	16	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:45867687T>C	uc002pbj.2	-	8	760	c.713A>G	c.(712-714)AAC>AGC	p.N238S	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.N160S|ERCC2_uc002pbk.2_Missense_Mutation_p.N214S|ERCC2_uc002pbl.3_Missense_Mutation_p.N214S|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	238	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CTCACCAATGTTGTGGGCCTC	0.637			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.003163	0	15	39										C	45867687	T	C	45867687	3	2	77	1	0	0	0	0	1	0	0	0	5213	1725	60	5	1690	5	ERCC2	19	45867687	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1090266	45867687	13261296	347	23376										
DMWD	1762	broad.mit.edu	37	chr19	46290118	46290118	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	agatatgtcaccttggtcttGtcgatcaaccgctgccaggg	11	11	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:46290118G>T	uc002pdj.1	-	3	682	c.636C>A	c.(634-636)GAC>GAA	p.D212E	DMWD_uc002pdk.1_Missense_Mutation_p.D212E|DMWD_uc010eko.1_5'UTR	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	212	WD 1.				meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCTTGGTCTTGTCGATCAACC	0.582													1	0	1.5842e-08	0.001855	1.65358e-08	14	32										T	46290118	G	T	46290118	3	4	77	1	0	0	0	0	1	0	0	0	4593	1368	48	4	1400	4	DMWD	19	46290118	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	422431	46290118	12838865	348	23377										
STRN4	29888	broad.mit.edu	37	chr19	47226204	47226204	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccactgaggtggggaccccgTgctctgagggcacagggaag	17	11	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:47226204T>C	uc002pfl.2	-	14	1802	c.1769A>G	c.(1768-1770)CAC>CGC	p.H590R	STRN4_uc002pfm.2_Missense_Mutation_p.H597R|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	590	WD 4.					cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GGGGACCCCGTGCTCTGAGGG	0.662													0	0	0	0.009535	0	27	67										C	47226204	T	C	47226204	3	2	77	1	0	0	0	0	1	0	0	0	15330	1696	59	5	508	5	STRN4	19	47226204	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	936086	47226204	11902779	349	23378										
GPR77	27202	broad.mit.edu	37	chr19	47844239	47844239	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	atggtggcctgggtggctggGaaggtggcccgccggagggt	22	8	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:47844239G>T	uc010ela.1	+	2	401	c.183G>T	c.(181-183)GGG>GGT	p.G61G	GPR77_uc002pgk.1_Silent_p.G61G	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	61	Helical; Name=1; (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GGGTGGCTGGGAAGGTGGCCC	0.687													1	0	6.07207e-39	0.00361	6.94645e-39	76	258										T	47844239	G	T	47844239	2	4	77	1	0	0	0	0	0	0	0	1	6709	1161	41	3		3	GPR77	19	47844239	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	618035	47844239	11284744	350	23379										
DHX34	9704	broad.mit.edu	37	chr19	47879304	47879304	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgggccggggcctgtacccaCagctggccgtccccgacgcc	14	18	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:47879304C>T	uc010xyn.1	+	11	2772	c.2431C>T	c.(2431-2433)CAG>TAG	p.Q811*	DHX34_uc010xyo.1_5'Flank	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	811						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCTGTACCCACAGCTGGCCGT	0.607													0	0	0	0.006999	0	31	97										T	47879304	C	T	47879304	4	4	77	1	0	0	0	0	0	1	0	0	4507	479	17	2	2469	2	DHX34	19	47879304	Nonsense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	35065	47879304	11249679	351	23380										
MAMSTR	284358	broad.mit.edu	37	chr19	49217717	49217717	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cgcgccgcggcttcggccgcTcgcggggcggcgcgccgccg	19	19	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:49217717T>A	uc002pkg.2	-	7	691	c.629A>T	c.(628-630)GAG>GTG	p.E210V	MAMSTR_uc002pkf.2_Missense_Mutation_p.E107V	NM_001130915	NP_001124387	Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing	210	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			ovary(1)	1						CTTcggccgctcgcggggcgg	0.617													0	0	0	0.00308	0	8	4										A	49217717	T	A	49217717	3	1	77	1	0	0	0	0	1	0	0	0	9209	1551	54	5	634	5	MAMSTR	19	49217717	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	1338413	49217717	9911266	352	23381										
RASIP1	54922	broad.mit.edu	37	chr19	49238543	49238543	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtcaactgatcgaagtccccGgggtctgcagttccgatttg	12	11	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:49238543G>A	uc002pki.2	-	4	1286	c.1089C>T	c.(1087-1089)CCC>CCT	p.P363P		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	363					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CGAAGTCCCCGGGGTCTGCAG	0.672													0	0	0	0.010504	0	19	60										A	49238543	G	A	49238543	2	1	77	1	0	0	0	0	0	0	0	1	13078	1103	39	2		2	RASIP1	19	49238543	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	20826	49238543	9890440	353	23382										
HSD17B14	51171	broad.mit.edu	37	chr19	49316713	49316713	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gatctgaaccccacttctacCtgggccagcatgccctctcg	8	17	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:49316713C>T	uc002pkv.1	-	8	905	c.639G>A	c.(637-639)CAG>CAA	p.Q213Q	BCAT2_uc002pkq.3_5'Flank|BCAT2_uc002pkr.2_5'Flank|BCAT2_uc002pks.2_5'Flank|BCAT2_uc002pkt.2_5'Flank|BCAT2_uc010emh.1_5'Flank|BCAT2_uc010emi.1_5'Flank|BCAT2_uc010emj.1_5'Flank|HSD17B14_uc010emk.1_Intron	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	213					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		CCACTTCTACCTGGGCCAGCA	0.607													0	0	0	0.004482	0	6	3										T	49316713	C	T	49316713	2	4	77	1	0	0	0	0	0	0	0	1	7383	695	24	2		2	HSD17B14	19	49316713	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	78170	49316713	9812270	354	23383										
FUZ	80199	broad.mit.edu	37	chr19	50315535	50315535	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccaaacaccatttggagtagTctctccagcctcagctcaga	7	14	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:50315535T>C	uc002ppq.1	-	3	396	c.291A>G	c.(289-291)AGA>AGG	p.R97R	FUZ_uc002ppr.1_5'UTR|FUZ_uc002pps.1_Intron|FUZ_uc002ppt.1_Intron|FUZ_uc002ppu.1_Intron|FUZ_uc002ppv.1_Silent_p.R47R|FUZ_uc010ybd.1_Silent_p.R97R	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	97					cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TTTGGAGTAGTCTCTCCAGCC	0.333													0	0	0	0.004482	0	8	16										C	50315535	T	C	50315535	2	2	77	1	0	0	0	0	0	0	0	1	6112	1664	58	5		5	FUZ	19	50315535	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	998822	50315535	8813448	355	23384										
MYH14	79784	broad.mit.edu	37	chr19	50735294	50735294	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggagacgctggagtcgctgCgggtcctgggattcagccac	16	11	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:50735294C>T	uc002prr.1	+	9	1104	c.1057C>T	c.(1057-1059)CGG>TGG	p.R353W	MYH14_uc010enu.1_Missense_Mutation_p.R361W|MYH14_uc002prq.1_Missense_Mutation_p.R361W	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	353	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGAGTCGCTGCGGGTCCTGGG	0.662													0	0	0	0.010504	0	15	56										T	50735294	C	T	50735294	3	4	77	1	0	0	0	0	1	0	0	0	10033	759	27	2	1115	2	MYH14	19	50735294	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	419759	50735294	8393689	356	23385										
ZNF616	90317	broad.mit.edu	37	chr19	52619312	52619312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtggattctccggtgacataCaagatttgatctatgtctga	10	7	3	4			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:52619312C>T	uc002pym.2	-	4	1388	c.1105G>A	c.(1105-1107)GTA>ATA	p.V369I	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	369	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CGGTGACATACAAGATTTGAT	0.418													0	0	0	0.00361	0	47	58										T	52619312	C	T	52619312	3	4	77	1	0	0	0	0	1	0	0	0	18038	478	17	2	1244	2	ZNF616	19	52619312	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1884018	52619312	6509671	357	23386										
ZNF28	7576	broad.mit.edu	37	chr19	53311303	53311303	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttctccagcatcacatccctGtaaagagtcctctgagcagg	8	13	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:53311303G>T	uc002qad.2	-	3	219	c.99C>A	c.(97-99)TAC>TAA	p.Y33*	ZNF28_uc002qac.2_5'UTR|ZNF28_uc010eqe.2_Intron	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TCACATCCCTGTAAAGAGTCC	0.483													1	0	5.18039e-06	0.00308	5.32947e-06	7	77										T	53311303	G	T	53311303	4	4	77	1	0	0	0	0	0	1	0	0	17810	1392	48	4		4	ZNF28	19	53311303	Nonsense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	691991	53311303	5817680	358	23387										
ZNF548	147694	broad.mit.edu	37	chr19	57910511	57910511	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ggccttatgagtgcaacacaTgtgggaaattctttcggtac	11	8	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:57910511T>C	uc002qom.2	+	3	1106	c.856T>C	c.(856-858)TGT>CGT	p.C286R	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.C289R	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	286	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTGCAACACATGTGGGAAATT	0.433													0	0	0	0.008291	0	9	20										C	57910511	T	C	57910511	3	2	77	1	0	0	0	0	1	0	0	0	17977	1464	51	5	906	5	ZNF548	19	57910511	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	4599208	57910511	1218472	359	23388										
ZNF749	388567	broad.mit.edu	37	chr19	57956154	57956154	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aggtctgacctcattcaacaCaagaggattgacctcaggcc	9	12	4	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:57956154C>G	uc002qoq.2	+	3	1892	c.1638C>G	c.(1636-1638)CAC>CAG	p.H546Q	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TCATTCAACACAAGAGGATTG	0.463													0	0	0	0.008291	0	8	22										G	57956154	C	G	57956154	3	3	77	1	0	0	0	0	1	0	0	0	18128	477	17	4	1648	4	ZNF749	19	57956154	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	45643	57956154	1172829	360	23389										
ZNF329	79673	broad.mit.edu	37	chr19	58639356	58639356	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cggctgggaccctccctgctAtggagtctctgatgtactgc	12	13	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:58639356A>T	uc002qrn.2	-	4	1752	c.1515T>A	c.(1513-1515)CAT>CAA	p.H505Q	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	505	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		CCTCCCTGCTATGGAGTCTCT	0.512													0	0	0	0.00361	0	64	83										T	58639356	A	T	58639356	3	4	77	1	0	0	0	0	1	0	0	0	17844	446	16	5	114	5	ZNF329	19	58639356	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	683202	58639356	489627	361	23390										
PLCB1	23236	broad.mit.edu	37	chr20	8862423	8862423	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtcctcagaccctggaaaagTgaaccacaagactccctcca	7	15	1	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:8862423T>G	uc002wnb.2	+	32	3581	c.3578T>G	c.(3577-3579)GTG>GGG	p.V1193G	PLCB1_uc002wna.2_3'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1193					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCTGGAAAAGTGAACCACAAG	0.502													0	0	0	0.00361	0	59	68										G	8862423	T	G	8862423	3	3	77	1	0	0	0	0	1	0	0	0	12027	1696	59	5	3807	5	PLCB1	20	8862423	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08		8862423	54163097	362	23391										
SEL1L2	80343	broad.mit.edu	37	chr20	13856714	13856714	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gccatggaaaagtacttgaaGgcagtagcgttattttgcgg	13	6	0	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:13856714G>C	uc010gcf.2	-	12	1156	c.1074C>G	c.(1072-1074)GCC>GCG	p.A358A	SEL1L2_uc002woq.3_Silent_p.A219A|SEL1L2_uc010zrl.1_Silent_p.A358A|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	358	Extracellular (Potential).|Sel1-like 6.					integral to membrane	binding			ovary(2)	2						AGTACTTGAAGGCAGTAGCGT	0.373													0	0	0	0.00632	0	23	94										C	13856714	G	C	13856714	2	2	77	1	0	0	0	0	0	0	0	1	14011	987	35	4		4	SEL1L2	20	13856714	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	4994291	13856714	49168806	363	23392										
C20orf186	149954	broad.mit.edu	37	chr20	31688261	31688261	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ttcttggcctcattttccacAgaaggagataagctcatgat	8	9	3	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:31688261A>G	uc010zue.1	+	12	1614	c.1599A>G	c.(1597-1599)ACA>ACG	p.T533T		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	533						cytoplasm|extracellular region	lipid binding				0						CATTTTCCACAGAAGGAGATA	0.527													0	0	0	0.003163	0	5	33										G	31688261	A	G	31688261	2	3	77	1	0	0	0	0	0	0	0	1	2098	175	7	5		5	C20orf186	20	31688261	Silent	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	17831547	31688261	31337259	364	23393										
EDEM2	55741	broad.mit.edu	37	chr20	33735053	33735053	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccgagcgggatgagcagccgGaaaggcatagagctcgtgtc	16	10	0	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:33735053G>A	uc002xbo.2	-	1	109	c.9C>T	c.(7-9)TTC>TTT	p.F3F	EDEM2_uc010zuv.1_Intron|EDEM2_uc010zus.1_5'Flank|EDEM2_uc002xbq.2_Silent_p.F3F|EDEM2_uc010zut.1_5'UTR|EDEM2_uc002xbp.2_5'UTR|EDEM2_uc002xbn.2_5'UTR|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_5'UTR	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	3					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TGAGCAGCCGGAAAGGCATAG	0.677													0	0	0	0.00361	0	49	34										A	33735053	G	A	33735053	2	1	77	1	0	0	0	0	0	0	0	1	4912	1165	41	1		1	EDEM2	20	33735053	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2046792	33735053	29290467	365	23394										
CHD6	84181	broad.mit.edu	37	chr20	40049605	40049605	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtgggctccgtgagatgcaaTacctctggcctttcccccat	10	14	1	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:40049605T>A	uc002xka.1	-	31	5848	c.5670A>T	c.(5668-5670)GTA>GTT	p.V1890V		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1890					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGAGATGCAATACCTCTGGCC	0.388													0	0	0	0.003954	0	23	20										A	40049605	T	A	40049605	2	1	77	1	0	0	0	0	0	0	0	1	3329	1393	49	5		5	CHD6	20	40049605	Silent	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	6314552	40049605	22975915	366	23395										
KCNK15	60598	broad.mit.edu	37	chr20	43374640	43374640	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tgctgtcttcgacgcgctcgAgtccgaggcggaaagcggcc	15	13	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:43374640A>T	uc002xmr.2	+	1	153	c.89A>T	c.(88-90)GAG>GTG	p.E30V		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	30						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GACGCGCTCGAGTCCGAGGCG	0.721													0	0	0	0.009096	0	4	17										T	43374640	A	T	43374640	3	4	77	1	0	0	0	0	1	0	0	0	8062	304	11	5	91	5	KCNK15	20	43374640	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	3325035	43374640	19650880	367	23396										
STK4	6789	broad.mit.edu	37	chr20	43607147	43607147	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagattgttgctattaagcaAgttcctgtggaatcagacct	9	8	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:43607147A>T	uc002xnb.2	+	3	270	c.180A>T	c.(178-180)CAA>CAT	p.Q60H	STK4_uc010ggx.2_Missense_Mutation_p.Q60H|STK4_uc010ggy.2_Missense_Mutation_p.Q60H|STK4_uc010ggw.1_Missense_Mutation_p.Q60H	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	60	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				CTATTAAGCAAGTTCCTGTGG	0.413													0	0	0	0.001855	0	11	28										T	43607147	A	T	43607147	3	4	77	1	0	0	0	0	1	0	0	0	15305	69	3	5	190	5	STK4	20	43607147	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	232507	43607147	19418373	368	23397										
TAF4	6874	broad.mit.edu	37	chr20	60581776	60581776	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctctgctggatgaaggccgcGgagtcgggggtcagctgtct	17	10	3	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:60581776G>A	uc002ybs.2	-	7	2013	c.2013C>T	c.(2011-2013)TCC>TCT	p.S671S		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	671	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TGAAGGCCGCGGAGTCGGGGG	0.657													0	0	0	0.00361	0	99	93										A	60581776	G	A	60581776	2	1	77	1	0	0	0	0	0	0	0	1	15523	1103	39	2		2	TAF4	20	60581776	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	16974629	60581776	2443744	369	23398										
MRPS6	64968	broad.mit.edu	37	chr21	35497670	35497670	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctgctactttgaaacgtacGatagaggccctgatggacag	12	9	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:35497670G>A	uc002ytp.2	+	2	253	c.75G>A	c.(73-75)ACG>ACA	p.T25T		NM_032476	NP_115865	P82932	RT06_HUMAN	mitochondrial ribosomal protein S6	25					translation	mitochondrion|small ribosomal subunit	rRNA binding|structural constituent of ribosome			skin(1)	1						TGAAACGTACGATAGAGGCCC	0.418													0	0	0	0.00361	0	44	44										A	35497670	G	A	35497670	2	1	77	1	0	0	0	0	0	0	0	1	9847	1045	37	1		1	MRPS6	21	35497670	Silent	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08		35497670	12632225	370	23399										
DSCR6	53820	broad.mit.edu	37	chr21	38390265	38390265	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagtgcaagccacgattgacTtctacgacgatgagtctact	9	11	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:38390265T>G	uc002yvv.2	+	4	541	c.331T>G	c.(331-333)TTC>GTC	p.F111V	DSCR6_uc011aec.1_5'UTR|DSCR6_uc010gnd.2_5'UTR	NM_018962	NP_061835	P57055	DSCR6_HUMAN	Down syndrome critical region protein 6	111	Ripply homology domain.					nucleus				breast(1)	1		Myeloproliferative disorder(46;0.0632)				CACGATTGACTTCTACGACGA	0.537													0	0	0	0.00245	0	12	29										G	38390265	T	G	38390265	3	3	77	1	0	0	0	0	1	0	0	0	4773	1609	56	5	345	5	DSCR6	21	38390265	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	2892595	38390265	9739630	371	23400										
TFF1	7031	broad.mit.edu	37	chr21	43786556	43786556	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cagggtgccgagggccagcaTggacaccaggaccagggcgc	17	13	0	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:43786556T>C	uc002zax.1	-	1	89	c.49A>G	c.(49-51)ATG>GTG	p.M17V		NM_003225	NP_003216	P04155	TFF1_HUMAN	trefoil factor 1 precursor	17					carbohydrate metabolic process|response to estradiol stimulus		growth factor activity				0						AGGGCCAGCATGGACACCAGG	0.667													0	0	0	0.00333	0	20	46										C	43786556	T	C	43786556	3	2	77	1	0	0	0	0	1	0	0	0	15800	1464	51	5	217	5	TFF1	21	43786556	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	5396291	43786556	4343339	372	23401										
ICOSLG	23308	broad.mit.edu	37	chr21	45656811	45656811	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	aatcccagggattggctcaaCaccaggcagtgaaacttctg	10	11	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:45656811C>A	uc002zee.2	-	3	479	c.345G>T	c.(343-345)GTG>GTT	p.V115V	ICOSLG_uc011afc.1_Silent_p.V25V|ICOSLG_uc002zef.2_Intron|ICOSLG_uc010gpp.1_Silent_p.V115V	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	115	Ig-like V-type.|Extracellular (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		ATTGGCTCAACACCAGGCAGT	0.607													1	0	7.75977e-34	0.00361	8.83008e-34	57	90										A	45656811	C	A	45656811	2	1	77	1	0	0	0	0	0	0	0	1	7487	465	17	4		4	ICOSLG	21	45656811	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	1870255	45656811	2473084	373	23402										
MCM3AP	8888	broad.mit.edu	37	chr21	47700482	47700482	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ccttctttctagccagggctGcagatgcctggaaaacagtc	10	12	2	1			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:47700482G>A	uc002zir.1	-	3	1487	c.1451C>T	c.(1450-1452)GCA>GTA	p.A484V		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	484					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					AGCCAGGGCTGCAGATGCCTG	0.403													0	0	0	0.002299	0	17	30										A	47700482	G	A	47700482	3	1	77	1	0	0	0	0	1	0	0	0	9388	1319	46	2	4595	2	MCM3AP	21	47700482	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	2043671	47700482	429413	374	23403										
DGCR8	54487	broad.mit.edu	37	chr22	20074109	20074109	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gttagaagattttactgacaAtttggagctagatgaagaag	11	3	0	6			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:20074109A>G	uc002zri.2	+	2	973	c.623A>G	c.(622-624)AAT>AGT	p.N208S	DGCR8_uc010grz.2_Missense_Mutation_p.N208S|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	208	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TTTACTGACAATTTGGAGCTA	0.478													0	0	0	0.00361	0	47	19										G	20074109	A	G	20074109	3	3	77	1	0	0	0	0	1	0	0	0	4464	101	4	5	625	5	DGCR8	22	20074109	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08		20074109	31230457	375	23404										
FOXRED2	80020	broad.mit.edu	37	chr22	36902136	36902136	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gtaggcacgcgagtagtgtcTgaagagcagccgggggtcgt	18	8	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:36902136T>C	uc003apn.3	-	1	442	c.334A>G	c.(334-336)AGA>GGA	p.R112G	FOXRED2_uc003apo.3_Missense_Mutation_p.R112G|FOXRED2_uc003app.3_Missense_Mutation_p.R112G	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	112					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GAGTAGTGTCTGAAGAGCAGC	0.627													0	0	0	0.00361	0	96	52										C	36902136	T	C	36902136	3	2	77	1	0	0	0	0	1	0	0	0	6034	1588	55	5	1752	5	FOXRED2	22	36902136	Missense_Mutation	SNP	T	TCGA-FD-A3N5-01A-11D-A21A-08	16828027	36902136	14402430	376	23405										
CSF2RB	1439	broad.mit.edu	37	chr22	37318275	37318275	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	gctggcccaggggctgctctCcatggccctgctggccctgt	14	16	1	0			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:37318275C>A	uc003aqa.3	+	2	243	c.26C>A	c.(25-27)TCC>TAC	p.S9Y	CSF2RB_uc003aqc.3_Missense_Mutation_p.S9Y	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	9					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GGGCTGCTCTCCATGGCCCTG	0.672													1	0	4.22769e-11	0.00632	4.5229e-11	20	6										A	37318275	C	A	37318275	3	1	77	1	0	0	0	0	1	0	0	0	3935	855	30	3	28	3	CSF2RB	22	37318275	Missense_Mutation	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08	416139	37318275	13986291	377	23406										
ARFGAP3	26286	broad.mit.edu	37	chr22	43218291	43218291	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	cttacattgattcttctttaGataccaccttggccaggtct	6	11	3	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:43218291G>C	uc003bdd.2	-	9	1017	c.797C>G	c.(796-798)TCT>TGT	p.S266C	ARFGAP3_uc010gzf.2_Missense_Mutation_p.S222C|ARFGAP3_uc011apu.1_Missense_Mutation_p.S194C	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	266					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						TTCTTCTTTAGATACCACCTT	0.338													0	0	0	0.001882	0	19	12										C	43218291	G	C	43218291	3	2	77	1	0	0	0	0	1	0	0	0	851	942	33	1	785	1	ARFGAP3	22	43218291	Missense_Mutation	SNP	G	TCGA-FD-A3N5-01A-11D-A21A-08	5900016	43218291	8086275	378	23407										
FANCB	2187	broad.mit.edu	37	chrX	14863348	14863348	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctattttgacactttagaagCcgaaatctggagtcatgggc	10	8	2	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:14863348C>A	uc004cwg.1	-	8	1825	c.1557G>T	c.(1555-1557)CGG>CGT	p.R519R	FANCB_uc004cwh.1_Silent_p.R519R	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	519					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					ACTTTAGAAGCCGAAATCTGG	0.388								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	4.35082e-09	0.010504	4.56357e-09	19	6										A	14863348	C	A	14863348	2	1	77	1	0	0	0	0	0	0	0	1	5663	726	26	4		4	FANCB	23	14863348	Silent	SNP	C	TCGA-FD-A3N5-01A-11D-A21A-08		14863348	140407212	379	23408										
KDM6A	7403	broad.mit.edu	37	chrX	44922670	44922670	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	ctttgtttttttgacagatgAgaccaacaggagttgcacag	10	7	0	3			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:44922670A>T	uc004dge.3	+	16	1906	c.1531A>T	c.(1531-1533)AGA>TGA	p.R511*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R477*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R563*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R466*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R518*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R215*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R150*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	511					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTGACAGATGAGACCAACAGG	0.433			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.00361	0	42	8										T	44922670	A	T	44922670	4	4	77	1	0	0	0	0	0	1	0	0	8137	296	11	5	1593	5	KDM6A	23	44922670	Nonsense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	30059322	44922670	110347890	380	23409										
AKAP4	8852	broad.mit.edu	37	chrX	49957631	49957631	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	catattgagtactctgagccAtatagcccatggtggaacca	9	10	1	2			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:49957631A>C	uc004dow.1	-	5	1857	c.1733T>G	c.(1732-1734)ATG>AGG	p.M578R	AKAP4_uc004dov.1_Missense_Mutation_p.M195R|AKAP4_uc010njp.1_Missense_Mutation_p.M400R|AKAP4_uc004dou.1_Missense_Mutation_p.M569R	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	578					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					ACTCTGAGCCATATAGCCCAT	0.483													0	0	0	0.004007	0	16	8										C	49957631	A	C	49957631	3	2	77	1	0	0	0	0	1	0	0	0	453	217	8	5	839	5	AKAP4	23	49957631	Missense_Mutation	SNP	A	TCGA-FD-A3N5-01A-11D-A21A-08	5034961	49957631	105312929	381	23410										
TAF9B	51616	broad.mit.edu	37	chrX	77387128	77387139	+	In_Frame_Del	DEL	ATCATCTTCATG	ATCATCTTCATG	-													0.0785340314136126	30	0.143947269367261	1.23086363757637	1.66987166831194	1.06826807063727	0.0967141061504539	0.217754357439058	0	tacataatatcattgtcatcAtcatcttcatgttttctctt							TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:77387128_77387139delATCATCTTCATG	uc004eda.2	-	7	795_806	c.724_735delCATGAAGATGAT	c.(724-735)CATGAAGATGATdel	p.HEDD242del		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	242_245	Poly-Asp.				negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						CATTGTCATCATCATCTTCATGTTTTCTCTTC	0.354																		19	11	---	---								-	77387139	ATCATCTTCATG	-	77387128	7	5	77	1	0	1	0	1	0	0	0	0	15533	214	8	0	24	0	TAF9B	23	77387128	In_Frame_Del	DEL	ATCATCTTCATG	TCGA-FD-A3N5-01A-11D-A21A-08	27429497	77387128	77883432	382	23411										
EIF4G3	8672	broad.mit.edu	37	chr1	21329220	21329220	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acttaccggagaacgggtttGaggttgtgaattcattgtct	12	6	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:21329220G>A	uc001bec.2	-	3	272	c.16C>T	c.(16-18)CAA>TAA	p.Q6*	EIF4G3_uc010odj.1_Nonsense_Mutation_p.Q6*|EIF4G3_uc009vpz.2_Nonsense_Mutation_p.Q6*|EIF4G3_uc001bed.2_Nonsense_Mutation_p.Q6*|EIF4G3_uc001bef.2_Nonsense_Mutation_p.Q6*|EIF4G3_uc001bee.2_Nonsense_Mutation_p.Q6*|EIF4G3_uc001beg.2_Nonsense_Mutation_p.Q6*|EIF4G3_uc010odk.1_Nonsense_Mutation_p.Q6*|EIF4G3_uc001beh.2_Nonsense_Mutation_p.Q6*	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	6					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GAACGGGTTTGAGGTTGTGAA	0.443													0	0	0	0.01441	0	70	143										A	21329220	G	A	21329220	4	1	78	1	0	0	0	0	0	1	0	0	5038	1299	45	1	4861	1	EIF4G3	1	21329220	Nonsense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		21329220	227921401	1	23412										
KIAA1522	57648	broad.mit.edu	37	chr1	33235330	33235330	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctggaaagtcagggcggcgtCggcgggagcggcggagcact	20	10	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:33235330C>T	uc001bvv.2	+	5	602	c.466C>T	c.(466-468)CGG>TGG	p.R156W	KIAA1522_uc001bvu.1_Missense_Mutation_p.R215W|KIAA1522_uc010ohm.1_Missense_Mutation_p.R167W|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	156	Poly-Arg.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGGCGGCGTCGGCGGGAGCG	0.627													0	0	0	0.010729	0	9	45										T	33235330	C	T	33235330	3	4	78	1	0	0	0	0	1	0	0	0	8238	875	31	1	661	1	KIAA1522	1	33235330	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	11906110	33235330	216015291	2	23413										
KIAA1522	57648	broad.mit.edu	37	chr1	33236198	33236198	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gggcagcactgctgaggcctCagacacactcagcattcgga	12	13	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:33236198C>G	uc001bvv.2	+	6	1377	c.1241C>G	c.(1240-1242)TCA>TGA	p.S414*	KIAA1522_uc001bvu.1_Nonsense_Mutation_p.S473*|KIAA1522_uc010ohm.1_Nonsense_Mutation_p.S425*|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	414	Ser-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GCTGAGGCCTCAGACACACTC	0.677													0	0	0	0.006214	0	7	67										G	33236198	C	G	33236198	4	3	78	1	0	0	0	0	0	1	0	0	8238	838	29	1	1440	1	KIAA1522	1	33236198	Nonsense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	868	33236198	216014423	3	23414										
CYP4B1	1580	broad.mit.edu	37	chr1	47283813	47283813	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtcccttcaggtctttgactCtctgcgcttttccactgaga	8	13	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:47283813C>G	uc001cqm.3	+	11	1364	c.1280C>G	c.(1279-1281)TCT>TGT	p.S427C	CYP4B1_uc001cqn.3_Missense_Mutation_p.S428C|CYP4B1_uc009vym.2_Missense_Mutation_p.S413C|CYP4B1_uc010omk.1_Missense_Mutation_p.S264C	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	427					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					GTCTTTGACTCTCTGCGCTTT	0.582													0	0	0	0.007413	0	16	107										G	47283813	C	G	47283813	3	3	78	1	0	0	0	0	1	0	0	0	4185	913	32	1	1325	1	CYP4B1	1	47283813	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	14047615	47283813	201966808	4	23415										
PCSK9	255738	broad.mit.edu	37	chr1	55521852	55521852	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctgcctctactccccagcctCagctcccgaggtaggtgctg	10	17	2	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:55521852C>T	uc001cyf.1	+	6	1277	c.986C>T	c.(985-987)TCA>TTA	p.S329L	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	329	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TCCCCAGCCTCAGCTCCCGAG	0.507													0	0	0	0.008291	0	8	9										T	55521852	C	T	55521852	3	4	78	1	0	0	0	0	1	0	0	0	11606	838	29	1	1008	1	PCSK9	1	55521852	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	8238039	55521852	193728769	5	23416										
DEPDC1	55635	broad.mit.edu	37	chr1	68949729	68949729	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgttctgaatacatctcgttCaaatccaacataagttggat	6	8	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:68949729C>G	uc001dem.3	-	7	931	c.814G>C	c.(814-816)GAA>CAA	p.E272Q	DEPDC1_uc001dej.3_5'Flank|DEPDC1_uc001dek.3_RNA|DEPDC1_uc001del.3_Missense_Mutation_p.E272Q	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	272					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		ACATCTCGTTCAAATCCAACA	0.294													0	0	0	0.016723	0	9	29										G	68949729	C	G	68949729	3	3	78	1	0	0	0	0	1	0	0	0	4439	835	29	1	1645	1	DEPDC1	1	68949729	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	13427877	68949729	180300892	6	23417										
LRRIQ3	127255	broad.mit.edu	37	chr1	74649182	74649182	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttgaagtggatgaatatctgTaataaaattgtttgagaaga	10	1	1	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:74649182T>C	uc001dfy.3	-	2	379	c.187A>G	c.(187-189)ACA>GCA	p.T63A	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	63	LRR 1.									ovary(2)	2						TGAATATCTGTAATAAaattg	0.154													0	0	0	0.007413	0	16	18										C	74649182	T	C	74649182	3	2	78	1	0	0	0	0	1	0	0	0	9030	1638	57	5	1715	5	LRRIQ3	1	74649182	Missense_Mutation	SNP	T	TCGA-FD-A3NA-01A-11D-A21A-08	5699453	74649182	174601439	7	23418										
RTCD1	8634	broad.mit.edu	37	chr1	100756986	100756986	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttattgtgaagaaatcagaaGatgaagaagacgccgctaaa	10	5	1	7			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:100756986G>C	uc001dtc.2	+	11	1245	c.1027G>C	c.(1027-1029)GAT>CAT	p.D343H	RTCD1_uc001dtd.2_Missense_Mutation_p.D356H	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	343					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		GAAATCAGAAGATGAAGAAGA	0.358													0	0	0	0.028581	0	13	51										C	100756986	G	C	100756986	3	2	78	1	0	0	0	0	1	0	0	0	13718	942	33	1	1112	1	RTCD1	1	100756986	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	26107804	100756986	148493635	8	23419										
DCST2	127579	broad.mit.edu	37	chr1	154995858	154995858	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acagctccaggtccaggtccCcctggtaggagaggggagat	15	11	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:154995858C>A	uc001fgm.2	-	13	2026	c.1946G>T	c.(1945-1947)GGG>GTG	p.G649V	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	649	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTCCAGGTCCCCCTGGTAGGA	0.602													1	0	2.62699e-14	0.024245	2.79982e-14	11	21										A	154995858	C	A	154995858	3	1	78	1	0	0	0	0	1	0	0	0	4303	623	22	4	387	4	DCST2	1	154995858	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	54238872	154995858	94254763	9	23420										
GBA	2629	broad.mit.edu	37	chr1	155207361	155207361	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acttgtgctcagcataggcaTccaggaacctggcaagagaa	11	10	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:155207361T>A	uc001fjh.2	-	7	920	c.770A>T	c.(769-771)GAT>GTT	p.D257V	RAG1AP1_uc010pey.1_Intron|GBA_uc010pfw.1_Missense_Mutation_p.D144V|GBA_uc010pfx.1_Missense_Mutation_p.D208V|GBA_uc001fji.2_Missense_Mutation_p.D257V|GBA_uc001fjj.2_Missense_Mutation_p.D257V|GBA_uc001fjk.2_Missense_Mutation_p.D257V|GBA_uc001fjl.2_Missense_Mutation_p.D257V|GBA_uc010pfy.1_Missense_Mutation_p.D170V|GBA_uc009wqk.1_Missense_Mutation_p.D170V	NM_000157	NP_000148	P04062	GLCM_HUMAN	glucocerebrosidase precursor	257					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			ovary(1)|skin(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	AGCATAGGCATCCAGGAACCT	0.423									Gaucher_disease_type_I				0	0	0	0.008871	0	9	13										A	155207361	T	A	155207361	3	1	78	1	0	0	0	0	1	0	0	0	6266	1435	50	5	860	5	GBA	1	155207361	Missense_Mutation	SNP	T	TCGA-FD-A3NA-01A-11D-A21A-08	211503	155207361	94043260	10	23421										
ASH1L	55870	broad.mit.edu	37	chr1	155449087	155449087	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gggaatggtctcatcactatGagactcactgattggggaag	13	7	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:155449087G>A	uc009wqq.2	-	3	4054	c.3574C>T	c.(3574-3576)CAT>TAT	p.H1192Y	ASH1L_uc001fkt.2_Missense_Mutation_p.H1192Y|ASH1L_uc009wqr.1_Missense_Mutation_p.H1192Y	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1192					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TCATCACTATGAGACTCACTG	0.443													0	0	0	0.013726	0	28	47										A	155449087	G	A	155449087	3	1	78	1	0	0	0	0	1	0	0	0	1041	1290	45	1	5424	1	ASH1L	1	155449087	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	241726	155449087	93801534	11	23422										
ASH1L	55870	broad.mit.edu	37	chr1	155449222	155449222	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cttcttcattgcaagagtctGaatcatactgccctgtctgg	8	11	5	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:155449222G>A	uc009wqq.2	-	3	3919	c.3439C>T	c.(3439-3441)CAG>TAG	p.Q1147*	ASH1L_uc001fkt.2_Nonsense_Mutation_p.Q1147*|ASH1L_uc009wqr.1_Nonsense_Mutation_p.Q1147*	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1147					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GCAAGAGTCTGAATCATACTG	0.473													0	0	0	0.00499	0	16	46										A	155449222	G	A	155449222	4	1	78	1	0	0	0	0	0	1	0	0	1041	1299	45	1	5559	1	ASH1L	1	155449222	Nonsense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	135	155449222	93801399	12	23423										
TNN	63923	broad.mit.edu	37	chr1	175066815	175066815	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaggctgacaccaacgccccGacaggtaacaaaagagagat	10	11	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:175066815G>A	uc001gkl.1	+	8	1964	c.1851G>A	c.(1849-1851)CCG>CCA	p.P617P	TNN_uc010pmx.1_Intron	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	617	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCAACGCCCCGACAGGTAACA	0.512													0	0	0	0.021553	0	4	94										A	175066815	G	A	175066815	2	1	78	1	0	0	0	0	0	0	0	1	16320	1045	37	1		1	TNN	1	175066815	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	19617593	175066815	74183806	13	23424										
FAM5B	57795	broad.mit.edu	37	chr1	177245417	177245417	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcacatgcagctctgagggtGagctcgtctgcaaggagaat	13	9	3	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:177245417G>A	uc001glf.2	+	6	1171	c.859G>A	c.(859-861)GAG>AAG	p.E287K	FAM5B_uc010pna.1_Missense_Mutation_p.E37K|FAM5B_uc001glg.2_Missense_Mutation_p.E182K	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	287						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CTCTGAGGGTGAGCTCGTCTG	0.572													0	0	0	0.010504	0	18	54										A	177245417	G	A	177245417	3	1	78	1	0	0	0	0	1	0	0	0	5593	1291	45	1	877	1	FAM5B	1	177245417	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2178602	177245417	72005204	14	23425										
CFHR1	3078	broad.mit.edu	37	chr1	196794771	196794771	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctcgcataacatgcacagaaGaaggatggtcaccaacacca	8	12	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:196794771G>C	uc001gtn.2	+	2	337	c.223G>C	c.(223-225)GAA>CAA	p.E75Q	CFHR1_uc001gtm.2_Intron	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	75	Sushi 1.				complement activation	extracellular space					0						ATGCACAGAAGAAGGATGGTC	0.388													0	0	0	0.008361	0	21	46										C	196794771	G	C	196794771	3	2	78	1	0	0	0	0	1	0	0	0	3284	943	33	1	229	1	CFHR1	1	196794771	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	19549354	196794771	52455850	15	23426										
MTR	4548	broad.mit.edu	37	chr1	236978926	236978926	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agccttgtttgcactccaaaAtctttttgaggagaaatatg	8	7	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:236978926A>G	uc001hyi.3	+	7	1055	c.632A>G	c.(631-633)AAT>AGT	p.N211S	MTR_uc010pxv.1_RNA|MTR_uc010pxw.1_5'UTR|MTR_uc010pxx.1_Missense_Mutation_p.N211S|MTR_uc010pxy.1_Missense_Mutation_p.N211S|MTR_uc009xgj.1_Missense_Mutation_p.I42V	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	211	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GCACTCCAAAATCTTTTTGAG	0.363													0	0	0	0.014323	0	17	50										G	236978926	A	G	236978926	3	3	78	1	0	0	0	0	1	0	0	0	9958	101	4	5	658	5	MTR	1	236978926	Missense_Mutation	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08	40184155	236978926	12271695	16	23427										
C2orf44	80304	broad.mit.edu	37	chr2	24260579	24260579	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtgaacataaggaagatcttGagagagtggatacactgaag	13	4	1	5			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:24260579G>C	uc002rep.2	-	2	1917	c.1786C>G	c.(1786-1788)CAA>GAA	p.Q596E	C2orf44_uc010eya.2_Missense_Mutation_p.Q596E	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	596							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAAGATCTTGAGAGAGTGGA	0.403													0	0	0	0.010771	0	34	91										C	24260579	G	C	24260579	3	2	78	1	0	0	0	0	1	0	0	0	2168	1299	45	1	391	1	C2orf44	2	24260579	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		24260579	218938794	17	23428										
SPTBN1	6711	broad.mit.edu	37	chr2	54855387	54855387	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agttcgcaacagacggggaaGgtaaggatggcccattccaa	13	9	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:54855387G>A	uc002rxu.2	+	13	2047	c.1798G>A	c.(1798-1800)GGT>AGT	p.G600S	SPTBN1_uc002rxv.1_Missense_Mutation_p.G600S|SPTBN1_uc002rxx.2_Missense_Mutation_p.G587S	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	600	Spectrin 3.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGACGGGGAAGGTAAGGATGG	0.507													0	0	0	0.009096	0	3	47										A	54855387	G	A	54855387	3	1	78	1	0	0	0	0	1	0	0	0	15118	1014	35	2	1957	2	SPTBN1	2	54855387	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	30594808	54855387	188343986	18	23429										
CCDC88A	55704	broad.mit.edu	37	chr2	55522809	55522809	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggcagtctactgtccttggtCaaaaaatcatggatgcttgt	10	8	3	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:55522809C>G	uc002ryv.2	-	31	6314	c.5472G>C	c.(5470-5472)TTG>TTC	p.L1824F	CCDC88A_uc010yoz.1_Missense_Mutation_p.L1797F|CCDC88A_uc010ypa.1_Missense_Mutation_p.L1750F|CCDC88A_uc002ryt.2_Missense_Mutation_p.L115F|CCDC88A_uc010fbw.2_Missense_Mutation_p.L326F|CCDC88A_uc002ryu.2_Missense_Mutation_p.L1079F|CCDC88A_uc002rys.2_Missense_Mutation_p.L782F|CCDC88A_uc002ryw.2_Missense_Mutation_p.L1108F|CCDC88A_uc010fby.1_Missense_Mutation_p.L676F	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1825					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TGTCCTTGGTCAAAAAATCAT	0.458													0	0	0	0.01441	0	43	147										G	55522809	C	G	55522809	3	3	78	1	0	0	0	0	1	0	0	0	2863	825	29	1	148	1	CCDC88A	2	55522809	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	667422	55522809	187676564	19	23430										
FBXO48	554251	broad.mit.edu	37	chr2	68692016	68692016	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atcatcatctatttctcttcGgcacacagctcttacagtca	4	13	6	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:68692016G>C	uc002seo.2	-	3	670	c.262C>G	c.(262-264)CGA>GGA	p.R88G	APLF_uc010fdf.2_5'Flank|APLF_uc002sep.2_5'Flank	NM_001024680	NP_001019851	Q5FWF7	FBX48_HUMAN	F-box protein 48	88											0						ATTTCTCTTCGGCACACAGCT	0.428													0	0	0	0.00632	0	23	140										C	68692016	G	C	68692016	3	2	78	1	0	0	0	0	1	0	0	0	5757	1124	39	4	213	4	FBXO48	2	68692016	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	13169207	68692016	174507357	20	23431										
GPR45	11250	broad.mit.edu	37	chr2	105858447	105858447	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gccatagtgatgctgctgatGaccgtggtggggttcctggg	17	8	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:105858447G>A	uc002tco.1	+	1	248	c.132G>A	c.(130-132)ATG>ATA	p.M44I		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	44	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TGCTGCTGATGACCGTGGTGG	0.617													0	0	0	0.01441	0	74	193										A	105858447	G	A	105858447	3	1	78	1	0	0	0	0	1	0	0	0	6696	1290	45	1	134	1	GPR45	2	105858447	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	37166431	105858447	137340926	21	23432										
FMNL2	114793	broad.mit.edu	37	chr2	153483060	153483060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atttaaatgtggatgaatttGaggaaatattcaagacaaaa	8	2	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:153483060G>C	uc002tye.2	+	17	2351	c.1984G>C	c.(1984-1986)GAG>CAG	p.E662Q	FMNL2_uc010fob.2_Missense_Mutation_p.E118Q|FMNL2_uc002tyf.2_Missense_Mutation_p.E111Q	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	662	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						GGATGAATTTGAGGAAATATT	0.358													0	0	0	0.014758	0	5	9										C	153483060	G	C	153483060	3	2	78	1	0	0	0	0	1	0	0	0	5952	1291	45	1	2050	1	FMNL2	2	153483060	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	47624613	153483060	89716313	22	23433										
AGPS	8540	broad.mit.edu	37	chr2	178402841	178402841	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atggctaaaggaaagtatctCtgatgtcggctttgggatgc	13	6	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:178402841C>G	uc002ull.2	+	20	1942	c.1895C>G	c.(1894-1896)TCT>TGT	p.S632C	AGPS_uc010zfb.1_Missense_Mutation_p.S542C	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	632					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			GAAAGTATCTCTGATGTCGGC	0.378													0	0	0	0.00632	0	25	64										G	178402841	C	G	178402841	3	3	78	1	0	0	0	0	1	0	0	0	394	913	32	1	1973	1	AGPS	2	178402841	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	24919781	178402841	64796532	23	23434										
TTN	7273	broad.mit.edu	37	chr2	179436844	179436844	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atccagtgatagtggcttcaGtgaccttgactgtggcacac	11	10	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:179436844G>T	uc010zfg.1	-	275	66535	c.66311C>A	c.(66310-66312)ACT>AAT	p.T22104N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T15799N|TTN_uc010zfi.1_Missense_Mutation_p.T15732N|TTN_uc010zfj.1_Missense_Mutation_p.T15607N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23031							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGGCTTCAGTGACCTTGAC	0.478													1	0	1.02788e-11	0.00499	1.08598e-11	13	22										T	179436844	G	T	179436844	3	4	78	1	0	0	0	0	1	0	0	0	16732	1029	36	4	34112	4	TTN	2	179436844	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	1034003	179436844	63762529	24	23435										
WDR75	84128	broad.mit.edu	37	chr2	190334854	190334854	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttgtatattcaaaagggtatCtccagagagaaagtccagtg	10	6	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:190334854C>G	uc002uql.1	+	17	1932	c.1872C>G	c.(1870-1872)ATC>ATG	p.I624M	WDR75_uc002uqm.1_Missense_Mutation_p.I560M|WDR75_uc002uqn.1_Missense_Mutation_p.I402M|WDR75_uc002uqo.1_Missense_Mutation_p.I402M	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	624						nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAAGGGTATCTCCAGAGAGA	0.403													0	0	0	0.01441	0	47	87										G	190334854	C	G	190334854	3	3	78	1	0	0	0	0	1	0	0	0	17322	903	32	1	1938	1	WDR75	2	190334854	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	10898010	190334854	52864519	25	23436										
CCDC150	284992	broad.mit.edu	37	chr2	197590756	197590756	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcatgctgaacgcatagaagCtctaagaaagcagtttcaaa	9	8	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:197590756C>A	uc002utp.1	+	22	2624	c.2489C>A	c.(2488-2490)GCT>GAT	p.A830D	CCDC150_uc010zgs.1_Missense_Mutation_p.A477D|CCDC150_uc010zgt.1_Missense_Mutation_p.A247D|CCDC150_uc002utq.1_Missense_Mutation_p.A145D|CCDC150_uc002utr.1_Missense_Mutation_p.A145D	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	830	Potential.										0						CGCATAGAAGCTCTAAGAAAG	0.423													1	0	1.06961e-07	0.00308	1.11552e-07	7	16										A	197590756	C	A	197590756	3	1	78	1	0	0	0	0	1	0	0	0	2785	797	28	4	2575	4	CCDC150	2	197590756	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	7255902	197590756	45608617	26	23437										
PARD3B	117583	broad.mit.edu	37	chr2	205983760	205983760	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atgtggatctcgtagacaaaAcctttgctcagtaagcattt	8	8	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:205983760A>C	uc002var.1	+	7	1003	c.796A>C	c.(796-798)ACC>CCC	p.T266P	PARD3B_uc010fub.1_Missense_Mutation_p.T266P|PARD3B_uc002vao.1_Missense_Mutation_p.T266P|PARD3B_uc002vap.1_Missense_Mutation_p.T266P|PARD3B_uc002vaq.1_Missense_Mutation_p.T266P	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	266	PDZ 1.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CGTAGACAAAACCTTTGCTCA	0.363													0	0	0	0.010504	0	17	65										C	205983760	A	C	205983760	3	2	78	1	0	0	0	0	1	0	0	0	11444	43	2	5	822	5	PARD3B	2	205983760	Missense_Mutation	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08	8393004	205983760	37215613	27	23438										
IDH1	3417	broad.mit.edu	37	chr2	209104705	209104705	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggacaaaccagcacgctggtCatcatgccgagagagccata	11	12	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:209104705C>T	uc002vcs.2	-	8	1119	c.873G>A	c.(871-873)ATG>ATA	p.M291I	IDH1_uc002vct.2_Missense_Mutation_p.M291I|IDH1_uc002vcu.2_Missense_Mutation_p.M291I	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	291					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		GCACGCTGGTCATCATGCCGA	0.527			Mis		gliobastoma 								0	0	0	0.007413	0	15	60										T	209104705	C	T	209104705	3	4	78	1	0	0	0	0	1	0	0	0	7494	826	29	1	383	1	IDH1	2	209104705	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	3120945	209104705	34094668	28	23439										
SPEG	10290	broad.mit.edu	37	chr2	220309874	220309874	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtacagaggacgggcgctctCtatccacgtgtaagtaacgg	13	10	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:220309874C>G	uc010fwg.2	+	3	806	c.806C>G	c.(805-807)TCT>TGT	p.S269C	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Intron|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	269					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGGGCGCTCTCTATCCACGTG	0.612													0	0	0	0.004672	0	3	8										G	220309874	C	G	220309874	3	3	78	1	0	0	0	0	1	0	0	0	15035	913	32	1	816	1	SPEG	2	220309874	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	11205169	220309874	22889499	29	23440										
MFF	56947	broad.mit.edu	37	chr2	228194464	228194464	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgtatttactgtatttaaatGagtaaaggaacaagcagtga	9	3	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:228194464G>A	uc002vos.2	+	3	421	c.3G>A	c.(1-3)ATG>ATA	p.M1I	MFF_uc002vot.2_Intron|MFF_uc002vou.2_Missense_Mutation_p.M1I|MFF_uc002vov.2_Intron|MFF_uc002vow.2_Intron|MFF_uc002vox.2_Intron|MFF_uc002voy.2_Missense_Mutation_p.M1I|MFF_uc002voz.2_Intron	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	1	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						GTATTTAAATGAGTAAAGGAA	0.343													0	0	0	0.012319	0	17	53										A	228194464	G	A	228194464	3	1	78	1	0	0	0	0	1	0	0	0	9519	1290	45	1	5	1	MFF	2	228194464	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	7884590	228194464	15004909	30	23441										
THAP4	51078	broad.mit.edu	37	chr2	242572898	242572898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	taaatttgcacgccccagatCctgggggcgtaaagtcatcc	10	12	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:242572898C>T	uc002wbt.2	-	2	897	c.674G>A	c.(673-675)GGA>GAA	p.G225E		NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	225							DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		CGCCCCAGATCCTGGGGGCGT	0.557													0	0	0	0.008361	0	28	63										T	242572898	C	T	242572898	3	4	78	1	0	0	0	0	1	0	0	0	15843	855	30	1	1087	1	THAP4	2	242572898	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	14378434	242572898	626475	31	23442										
ATP2B2	491	broad.mit.edu	37	chr3	10401790	10401790	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cccacctgccgaggcagggcGccctccttctctgggggctg	14	17	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:10401790G>C	uc003bvt.2	-	13	2116	c.1677C>G	c.(1675-1677)GGC>GGG	p.G559G	ATP2B2_uc003bvv.2_Silent_p.G514G|ATP2B2_uc003bvw.2_Silent_p.G514G|ATP2B2_uc010hdo.2_Silent_p.G264G	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	559	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GAGGCAGGGCGCCCTCCTTCT	0.687													0	0	0	0.00874	0	30	53										C	10401790	G	C	10401790	2	2	78	1	0	0	0	0	0	0	0	1	1140	1074	38	4		4	ATP2B2	3	10401790	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		10401790	187620640	32	23443										
ULK4	54986	broad.mit.edu	37	chr3	41961238	41961238	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tttcataaagcagacagcccAaagaccagaggtcactggag	10	10	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:41961238A>G	uc003ckv.3	-	6	815	c.614T>C	c.(613-615)TTG>TCG	p.L205S	ULK4_uc003ckw.2_Missense_Mutation_p.L205S|ULK4_uc003ckx.1_Missense_Mutation_p.L205S	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	205	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CAGACAGCCCAAAGACCAGAG	0.413													0	0	0	0.019004	0	26	83										G	41961238	A	G	41961238	3	3	78	1	0	0	0	0	1	0	0	0	16975	131	5	5	3341	5	ULK4	3	41961238	Missense_Mutation	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08	31559448	41961238	156061192	33	23444										
LTF	4057	broad.mit.edu	37	chr3	46497843	46497843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtagggggccaggcctgcctCgtatatgaaaccaccatcaa	11	12	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:46497843C>T	uc003cpq.2	-	3	291	c.253G>A	c.(253-255)GAG>AAG	p.E85K	LTF_uc003fzr.2_Missense_Mutation_p.E41K|LTF_uc010hjh.2_Missense_Mutation_p.E85K|LTF_uc003cpr.2_Missense_Mutation_p.E72K	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	85	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	AGGCCTGCCTCGTATATGAAA	0.577													0	0	0	0.019004	0	25	84										T	46497843	C	T	46497843	3	4	78	1	0	0	0	0	1	0	0	0	9079	893	31	1	1939	1	LTF	3	46497843	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	4536605	46497843	151524587	34	23445										
PLXNB1	5364	broad.mit.edu	37	chr3	48465275	48465275	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggtcccggagacacactcgaGatacataggcacgaaaagct	11	11	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:48465275G>A	uc003csw.2	-	3	1016	c.746C>T	c.(745-747)TCT>TTT	p.S249F	PLXNB1_uc003csu.2_Missense_Mutation_p.S249F|PLXNB1_uc003csx.2_Missense_Mutation_p.S249F|PLXNB1_uc010hjx.1_RNA	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	249	Extracellular (Potential).|Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACACACTCGAGATACATAGGC	0.612													0	0	0	0.027894	0	36	74										A	48465275	G	A	48465275	3	1	78	1	0	0	0	0	1	0	0	0	12123	942	33	1	5805	1	PLXNB1	3	48465275	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	1967432	48465275	149557155	35	23446										
SEMA3F	6405	broad.mit.edu	37	chr3	50220147	50220147	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gatgataagctttacttcttCttccgtgagcggtcggcaga	11	9	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:50220147C>T	uc003cyj.2	+	9	1032	c.834C>T	c.(832-834)TTC>TTT	p.F278F	SEMA3F_uc003cyk.2_Silent_p.F247F	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	278	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		TTTACTTCTTCTTCCGTGAGC	0.627													0	0	0	0.01441	0	47	75										T	50220147	C	T	50220147	2	4	78	1	0	0	0	0	0	0	0	1	14029	912	32	1		1	SEMA3F	3	50220147	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	1754872	50220147	147802283	36	23447										
ADAMTS9	56999	broad.mit.edu	37	chr3	64536627	64536627	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttgcaaactacagctttcacGgtccaccggccgcttgctca	8	15	2	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:64536627G>A	uc003dmg.2	-	31	4842	c.4810C>T	c.(4810-4812)CGT>TGT	p.R1604C	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R1576C|ADAMTS9_uc003dmh.1_Missense_Mutation_p.R1433C|ADAMTS9_uc011bfp.1_Missense_Mutation_p.R515C	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1604	TSP type-1 13.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAGCTTTCACGGTCCACCGGC	0.572													0	0	0	0.01441	0	111	113										A	64536627	G	A	64536627	3	1	78	1	0	0	0	0	1	0	0	0	273	1116	39	2	1033	2	ADAMTS9	3	64536627	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	14316480	64536627	133485803	37	23448										
ADAMTS9	56999	broad.mit.edu	37	chr3	64599095	64599095	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	catagatgttggcttggtctCagggtcacacattctatcat	9	9	4	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:64599095C>T	uc003dmg.2	-	22	3312	c.3280G>A	c.(3280-3282)GAG>AAG	p.E1094K	ADAMTS9_uc011bfo.1_Missense_Mutation_p.E1066K|ADAMTS9_uc003dmh.1_Missense_Mutation_p.E923K|ADAMTS9_uc011bfp.1_Missense_Mutation_p.E5K	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1094	TSP type-1 5.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGCTTGGTCTCAGGGTCACAC	0.488													0	0	0	0.010504	0	17	102										T	64599095	C	T	64599095	3	4	78	1	0	0	0	0	1	0	0	0	273	835	29	1	2599	1	ADAMTS9	3	64599095	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	62468	64599095	133423335	38	23449										
FAM162A	26355	broad.mit.edu	37	chr3	122123148	122123148	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cacaaacctacggattggcaGaaaaagatcctcatatggtc	8	10	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:122123148G>A	uc003eez.2	+	3	291	c.201G>A	c.(199-201)CAG>CAA	p.Q67Q	FAM162A_uc011bjq.1_Silent_p.Q67Q	NM_014367	NP_055182	Q96A26	F162A_HUMAN	growth and transformation-dependent protein	67						integral to membrane				ovary(1)	1						CGGATTGGCAGAAAAAGATCC	0.373													0	0	0	0.008291	0	9	20										A	122123148	G	A	122123148	2	1	78	1	0	0	0	0	0	0	0	1	5474	933	33	1		1	FAM162A	3	122123148	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	57524053	122123148	75899282	39	23450										
UROC1	131669	broad.mit.edu	37	chr3	126202223	126202223	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctgacttacaccattggagaCatcccagctgagcatcagcc	8	14	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:126202223C>G	uc003eiz.1	-	19	1911	c.1879G>C	c.(1879-1881)GTC>CTC	p.V627L	UROC1_uc010hsi.1_Missense_Mutation_p.V687L	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	627					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		CCATTGGAGACATCCCAGCTG	0.617													0	0	0	0.021553	0	6	43										G	126202223	C	G	126202223	3	3	78	1	0	0	0	0	1	0	0	0	17025	478	17	4	159	4	UROC1	3	126202223	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	4079075	126202223	71820207	40	23451										
RAB43	339122	broad.mit.edu	37	chr3	128853792	128853792	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acgtgtctttctgggaggagGaagagctataagaaacagaa	13	5	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:128853792G>A	uc003elo.1	-	8	635	c.424C>T	c.(424-426)CCT>TCT	p.P142S	ISY1_uc010hsz.1_Intron|ISY1_uc003elp.1_Missense_Mutation_p.P142S|ISY1_uc010hta.1_Missense_Mutation_p.P164S	NM_020701	NP_065752	Q86YS6	RAB43_HUMAN	ISY1 splicing factor homolog	Error:Variant_position_missing_in_Q86YS6_after_alignment					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			lung(1)	1						CTGGGAGGAGGAAGAGCTATA	0.453													0	0	0	0.028581	0	14	30										A	128853792	G	A	128853792	3	1	78	1	0	0	0	0	1	0	0	0	12945	1174	41	1		1	RAB43	3	128853792	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2651569	128853792	69168638	41	23452										
COL6A6	131873	broad.mit.edu	37	chr3	130282320	130282320	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaaggccctgcggaaagacgGagtgaaaatcatctctgtag	12	8	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:130282320G>A	uc010htl.2	+	2	504	c.473G>A	c.(472-474)GGA>GAA	p.G158E		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	158	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CGGAAAGACGGAGTGAAAATC	0.498													0	0	0	0.009096	0	4	30										A	130282320	G	A	130282320	3	1	78	1	0	0	0	0	1	0	0	0	3703	1174	41	1	479	1	COL6A6	3	130282320	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	1428528	130282320	67740110	42	23453										
PPP2R3A	5523	broad.mit.edu	37	chr3	135720804	135720804	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgactcatttaataggaggtCagttgatttggacttgcttt	10	5	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:135720804C>T	uc003eqv.1	+	2	1029	c.464C>T	c.(463-465)TCA>TTA	p.S155L	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	155					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						AATAGGAGGTCAGTTGATTTG	0.398													0	0	0	0.001984	0	6	34										T	135720804	C	T	135720804	3	4	78	1	0	0	0	0	1	0	0	0	12388	838	29	1	466	1	PPP2R3A	3	135720804	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	5438484	135720804	62301626	43	23454										
CPA3	1359	broad.mit.edu	37	chr3	148596524	148596524	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctgttgaagataatccactaTatgttctgaaggtaaaaata	7	5	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:148596524T>C	uc003ewm.2	+	5	515	c.463T>C	c.(463-465)TAT>CAT	p.Y155H		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	155					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAATCCACTATATGTTCTGAA	0.313													0	0	0	0.007413	0	16	17										C	148596524	T	C	148596524	3	2	78	1	0	0	0	0	1	0	0	0	3791	1406	49	5	481	5	CPA3	3	148596524	Missense_Mutation	SNP	T	TCGA-FD-A3NA-01A-11D-A21A-08	12875720	148596524	49425906	44	23455										
IGSF10	285313	broad.mit.edu	37	chr3	151161338	151161338	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	accaatgttccgtcaaccgtCaccacagcctgcctacttcc	5	18	2	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:151161338C>G	uc011bod.1	-	5	5397	c.5397G>C	c.(5395-5397)GTG>GTC	p.V1799V	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1799	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CGTCAACCGTCACCACAGCCT	0.512													0	0	0	0.021523	0	22	45										G	151161338	C	G	151161338	2	3	78	1	0	0	0	0	0	0	0	1	7597	813	29	1		1	IGSF10	3	151161338	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	2564814	151161338	46861092	45	23456										
IGSF10	285313	broad.mit.edu	37	chr3	151166475	151166475	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cagctgcaaggaaatttggtCttgcattaaccaagagggat	11	7	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:151166475C>G	uc011bod.1	-	4	1294	c.1294G>C	c.(1294-1296)GAC>CAC	p.D432H		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	432					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GAAATTTGGTCTTGCATTAAC	0.428													0	0	0	0.024245	0	13	22										G	151166475	C	G	151166475	3	3	78	1	0	0	0	0	1	0	0	0	7597	913	32	1	6637	1	IGSF10	3	151166475	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	5137	151166475	46855955	46	23457										
PIK3CA	5290	broad.mit.edu	37	chr3	178928225	178928225	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cttccatctcttaggaaactCcatgcttagagttggagttt	8	9	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:178928225C>G	uc003fjk.2	+	9	1568	c.1411C>G	c.(1411-1413)CCA>GCA	p.P471A		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	471	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.P471A(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTAGGAAACTCCATGCTTAGA	0.368		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.024334	0	26	21										G	178928225	C	G	178928225	3	3	78	1	0	0	0	0	1	0	0	0	11913	855	30	1	1441	1	PIK3CA	3	178928225	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	27761750	178928225	19094205	47	23458										
TPRG1	285386	broad.mit.edu	37	chr3	188933083	188933083	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tttctcctttccacacagccGggggccattgagactgccat	9	14	1	1	rs141310543		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:188933083G>A	uc003frv.1	+	8	1440	c.213G>A	c.(211-213)CCG>CCA	p.P71P	TPRG1_uc003frw.1_Silent_p.P71P	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	71											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		CCACACAGCCGGGGGCCATTG	0.488													0	0	0	0.017118	0	25	23										A	188933083	G	A	188933083	2	1	78	1	0	0	0	0	0	0	0	1	16415	1103	39	2		2	TPRG1	3	188933083	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	10004858	188933083	9089347	48	23459										
CLDN1	9076	broad.mit.edu	37	chr3	190026071	190026071	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ccttttgcctctgtgtcacaCgtagtctttcccgctggaag	9	13	3	0	rs147881276		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:190026071C>G	uc003fsh.2	-	4	851	c.631G>C	c.(631-633)GTG>CTG	p.V211L		NM_021101	NP_066924	O95832	CLD1_HUMAN	claudin 1	211	Cytoplasmic (Potential).|Interactions with TJP1, TJP2, TJP3 and INADL (By similarity).				calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(1)	1	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		CTGTGTCACACGTAGTCTTTC	0.448													0	0	0	0.010818	0	22	150										G	190026071	C	G	190026071	3	3	78	1	0	0	0	0	1	0	0	0	3471	536	19	4	8	4	CLDN1	3	190026071	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	1092988	190026071	7996359	49	23460										
SLC34A2	10568	broad.mit.edu	37	chr4	25664188	25664188	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aagtacctcgaaggggccgcAggtcagcagcccactgcccc	12	16	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:25664188A>G	uc003grr.2	+	2	147	c.66A>G	c.(64-66)GCA>GCG	p.A22A	SLC34A2_uc003grs.2_Silent_p.A22A|SLC34A2_uc010iev.2_Silent_p.A22A	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	22	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				AAGGGGCCGCAGGTCAGCAGC	0.547													0	0	0	0.014758	0	3	102										G	25664188	A	G	25664188	2	3	78	1	0	0	0	0	0	0	0	1	14568	175	7	5		5	SLC34A2	4	25664188	Silent	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08		25664188	165490088	50	23461										
N4BP2	55728	broad.mit.edu	37	chr4	40146258	40146258	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgtttatgatttagggtactCttcatgagcagaagatgaaa	10	4	2	5			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:40146258C>G	uc003guy.3	+	16	5319	c.4981C>G	c.(4981-4983)CTT>GTT	p.L1661V	N4BP2_uc010ifq.2_Missense_Mutation_p.L1581V|N4BP2_uc010ifr.2_Missense_Mutation_p.L1564V	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1661						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTAGGGTACTCTTCATGAGCA	0.428													0	0	0	0.007291	0	24	62										G	40146258	C	G	40146258	3	3	78	1	0	0	0	0	1	0	0	0	10110	913	32	1	5035	1	N4BP2	4	40146258	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	14482070	40146258	151008018	51	23462										
FRAS1	80144	broad.mit.edu	37	chr4	79462137	79462137	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gaccgggtggagaagaacgtGaatagacactactgcactgt	13	8	0	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:79462137G>A	uc003hlb.2	+	74	12338	c.11898G>A	c.(11896-11898)GTG>GTA	p.V3966V		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3961	Cytoplasmic (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AGAAGAACGTGAATAGACACT	0.498													0	0	0	0.00308	0	6	98										A	79462137	G	A	79462137	2	1	78	1	0	0	0	0	0	0	0	1	6042	1277	45	1		1	FRAS1	4	79462137	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	39315879	79462137	111692139	52	23463										
CENPE	1062	broad.mit.edu	37	chr4	104082321	104082321	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttgtaattctttctccagatCaacttgcattttcttttttg	4	8	4	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:104082321C>T	uc003hxb.1	-	20	2143	c.2053G>A	c.(2053-2055)GAT>AAT	p.D685N	CENPE_uc003hxc.1_Missense_Mutation_p.D660N	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	685	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTCTCCAGATCAACTTGCATT	0.313													0	0	0	0.001984	0	6	16										T	104082321	C	T	104082321	3	4	78	1	0	0	0	0	1	0	0	0	3230	826	29	1	6172	1	CENPE	4	104082321	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	24620184	104082321	87071955	53	23464										
CENPE	1062	broad.mit.edu	37	chr4	104082409	104082409	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tatgtagttgcaagttctttCtattgagaaaaacattgcaa	7	5	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:104082409C>T	uc003hxb.1	-	20	2056	c.1966_splice	c.e20-1	p.K656_splice	CENPE_uc003hxc.1_Splice_Site_p.K631_splice	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CAAGTTCTTTCTATTGAGAAA	0.303													0	0	0	0.009096	0	3	13										T	104082409	C	T	104082409	5	4	78	1	0	0	0	0	0	0	1	0	3230	927	32	1	6260	1	CENPE	4	104082409	Splice_Site	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	88	104082409	87071867	54	23465										
SEC24B	10427	broad.mit.edu	37	chr4	110415839	110415839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aacctgatcctgcttctgctCcagctccagcttcagctcca	6	17	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:110415839C>T	uc003hzk.2	+	6	1370	c.1315C>T	c.(1315-1317)CCA>TCA	p.P439S	SEC24B_uc003hzl.2_Missense_Mutation_p.P404S|SEC24B_uc011cfp.1_Missense_Mutation_p.P470S|SEC24B_uc011cfq.1_Missense_Mutation_p.P439S|SEC24B_uc011cfr.1_Missense_Mutation_p.P404S	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	439					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGCTTCTGCTCCAGCTCCAGC	0.488													0	0	0	0.01441	0	40	107										T	110415839	C	T	110415839	3	4	78	1	0	0	0	0	1	0	0	0	13995	855	30	1	1337	1	SEC24B	4	110415839	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	6333430	110415839	80738437	55	23466										
FAT4	79633	broad.mit.edu	37	chr4	126238820	126238820	+	Silent	SNP	C	C	T													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agcaaagtgccgaacctgagCctaatcaaggtggccagcgc							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126238820C>T	uc003ifj.3	+	1	1254	c.1254C>T	c.(1252-1254)AGC>AGT	p.S418S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	418	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CGAACCTGAGCCTAATCAAGG	0.597											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	11	27										T	126238820	C	T	126238820	2	4	78	1	0	0	0	0	0	0	0	1	5692	738	26	2		2	FAT4	4	126238820	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	15822981	126238820	64915456	56	23467	116	2	1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126238826	126238826	+	Silent	SNP	C	C	T													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtgccgaacctgagcctaatCaaggtggccagcgccttgga							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126238826C>T	uc003ifj.3	+	1	1260	c.1260C>T	c.(1258-1260)ATC>ATT	p.I420I		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	420	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGAGCCTAATCAAGGTGGCCA	0.607											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.020292	0	12	29										T	126238826	C	T	126238826	2	4	78	1	0	0	0	0	0	0	0	1	5692	816	29	1		1	FAT4	4	126238826	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	6	126238826	64915450	57	23468	116	2	1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239094	126239094	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	actctggtctcaatgctaatCtgcgttacagcattgtctct	7	11	4	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239094C>G	uc003ifj.3	+	1	1528	c.1528C>G	c.(1528-1530)CTG>GTG	p.L510V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	510	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAATGCTAATCTGCGTTACAG	0.557											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	19	53										G	126239094	C	G	126239094	3	3	78	1	0	0	0	0	1	0	0	0	5692	912	32	1	1530	1	FAT4	4	126239094	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	268	126239094	64915182	58	23469			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239141	126239141	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggactgggatggttccatatCagtgaacatagcggcctcgt	13	9	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239141C>G	uc003ifj.3	+	1	1575	c.1575C>G	c.(1573-1575)ATC>ATG	p.I525M		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	525	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGTTCCATATCAGTGAACATA	0.537											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.015359	0	25	71										G	126239141	C	G	126239141	3	3	78	1	0	0	0	0	1	0	0	0	5692	816	29	1	1577	1	FAT4	4	126239141	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	47	126239141	64915135	59	23470			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239282	126239282	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcccagcttgtagtaactctCctagatgtgaatgatgaaaa	9	8	1	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239282C>G	uc003ifj.3	+	1	1716	c.1716C>G	c.(1714-1716)CTC>CTG	p.L572L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	572	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TAGTAACTCTCCTAGATGTGA	0.498											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	18	44										G	126239282	C	G	126239282	2	3	78	1	0	0	0	0	0	0	0	1	5692	842	30	1		1	FAT4	4	126239282	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	141	126239282	64914994	60	23471			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239473	126239473	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gaggtccttccgtctggatcCtgtgtctgggaggttgagta	15	8	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239473C>T	uc003ifj.3	+	1	1907	c.1907C>T	c.(1906-1908)CCT>CTT	p.P636L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	636	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CGTCTGGATCCTGTGTCTGGG	0.567													0	0	0	0.012319	0	21	34										T	126239473	C	T	126239473	3	4	78	1	0	0	0	0	1	0	0	0	5692	681	24	2	1909	2	FAT4	4	126239473	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	191	126239473	64914803	61	23472			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239494	126239494	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgtgtctgggaggttgagtaCtatttcctccttggacagag	13	7	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239494C>G	uc003ifj.3	+	1	1928	c.1928C>G	c.(1927-1929)ACT>AGT	p.T643S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	643	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGGTTGAGTACTATTTCCTCC	0.552													0	0	0	0.006122	0	17	29										G	126239494	C	G	126239494	3	3	78	1	0	0	0	0	1	0	0	0	5692	565	20	4	1930	4	FAT4	4	126239494	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	21	126239494	64914782	62	23473			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239578	126239578	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gggctcccctccccagtcatCaatggctcgcataaatgtga	9	14	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239578C>G	uc003ifj.3	+	1	2012	c.2012C>G	c.(2011-2013)TCA>TGA	p.S671*		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	671	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCCCAGTCATCAATGGCTCGC	0.488													0	0	0	0.00632	0	24	51										G	126239578	C	G	126239578	4	3	78	1	0	0	0	0	0	1	0	0	5692	838	29	1	2014	1	FAT4	4	126239578	Nonsense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	84	126239578	64914698	63	23474			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126239780	126239780	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gacaggtctcggtttcaggtCaatgctcagagtggggttat	14	7	4	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239780C>A	uc003ifj.3	+	1	2214	c.2214C>A	c.(2212-2214)GTC>GTA	p.V738V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	738	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGTTTCAGGTCAATGCTCAGA	0.453													1	0	3.27435e-08	0.020292	3.4296e-08	15	39										A	126239780	C	A	126239780	2	1	78	1	0	0	0	0	0	0	0	1	5692	813	29	3		3	FAT4	4	126239780	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	202	126239780	64914496	64	23475			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240344	126240344	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cctgatgaaggtgtcaatggCatggtactctatagtctgaa	11	7	3	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240344C>A	uc003ifj.3	+	1	2778	c.2778C>A	c.(2776-2778)GGC>GGA	p.G926G		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	926	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTGTCAATGGCATGGTACTCT	0.473													1	0	0.000978159	0.010729	0.00101146	8	40										A	126240344	C	A	126240344	2	1	78	1	0	0	0	0	0	0	0	1	5692	697	25	4		4	FAT4	4	126240344	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	564	126240344	64913932	65	23476			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240492	126240492	+	Missense_Mutation	SNP	C	C	T													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctgacatgggtgtcccacagCtctcctctagtgtcatctta							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240492C>T	uc003ifj.3	+	1	2926	c.2926C>T	c.(2926-2928)CTC>TTC	p.L976F		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	976	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGTCCCACAGCTCTCCTCTAG	0.443													0	0	0	0.014323	0	20	53										T	126240492	C	T	126240492	3	4	78	1	0	0	0	0	1	0	0	0	5692	797	28	2	2928	2	FAT4	4	126240492	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	148	126240492	64913784	66	23477	117	2	1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240499	126240499	+	Missense_Mutation	SNP	C	C	A													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gggtgtcccacagctctcctCtagtgtcatcttaacagttt							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240499C>A	uc003ifj.3	+	1	2933	c.2933C>A	c.(2932-2934)TCT>TAT	p.S978Y		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	978	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAGCTCTCCTCTAGTGTCATC	0.453													1	0	4.26978e-12	0.01892	4.53081e-12	22	55										A	126240499	C	A	126240499	3	1	78	1	0	0	0	0	1	0	0	0	5692	913	32	3	2935	3	FAT4	4	126240499	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	7	126240499	64913777	67	23478	117	2	1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240563	126240563	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcaccagtgtttgaccaactCtcttatgaagtcaccctttc	5	13	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240563C>G	uc003ifj.3	+	1	2997	c.2997C>G	c.(2995-2997)CTC>CTG	p.L999L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	999	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTGACCAACTCTCTTATGAAG	0.408													0	0	0	0.010771	0	34	85										G	126240563	C	G	126240563	2	3	78	1	0	0	0	0	0	0	0	1	5692	900	32	1		1	FAT4	4	126240563	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	64	126240563	64913713	68	23479			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240606	126240606	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agtcagaacctgtgaattctCgattctttaaagtacaagct	7	8	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240606C>G	uc003ifj.3	+	1	3040	c.3040C>G	c.(3040-3042)CGA>GGA	p.R1014G		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1014	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGTGAATTCTCGATTCTTTAA	0.383													0	0	0	0.00632	0	27	61										G	126240606	C	G	126240606	3	3	78	1	0	0	0	0	1	0	0	0	5692	876	31	1	3042	1	FAT4	4	126240606	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	43	126240606	64913670	69	23480			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240753	126240753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtgaactggaccgtgaacttCaagacagatatgttttaatg	10	6	1	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240753C>G	uc003ifj.3	+	1	3187	c.3187C>G	c.(3187-3189)CAA>GAA	p.Q1063E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1063	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCGTGAACTTCAAGACAGATA	0.373													0	0	0	0.01441	0	46	86										G	126240753	C	G	126240753	3	3	78	1	0	0	0	0	1	0	0	0	5692	827	29	1	3189	1	FAT4	4	126240753	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	147	126240753	64913523	70	23481			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126240826	126240826	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tagtgctactgtgaatgttaCtgtaattttagaagatgtaa	9	3	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240826C>G	uc003ifj.3	+	1	3260	c.3260C>G	c.(3259-3261)ACT>AGT	p.T1087S		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1087	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTGAATGTTACTGTAATTTTA	0.393													0	0	0	0.013114	0	38	100										G	126240826	C	G	126240826	3	3	78	1	0	0	0	0	1	0	0	0	5692	565	20	4	3262	4	FAT4	4	126240826	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	73	126240826	64913450	71	23482			1	105		17	15	2284	N	C	2.337655e-37
FAT4	79633	broad.mit.edu	37	chr4	126241103	126241103	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gctgtgtttagctttacagtCatagcaacagatcaggggat	11	7	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126241103C>G	uc003ifj.3	+	1	3537	c.3537C>G	c.(3535-3537)GTC>GTG	p.V1179V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1179	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCTTTACAGTCATAGCAACAG	0.428													0	0	0	0.010771	0	36	69										G	126241103	C	G	126241103	2	3	78	1	0	0	0	0	0	0	0	1	5692	813	29	1		1	FAT4	4	126241103	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	277	126241103	64913173	72	23483			1	105		17	15	2284	N	C	2.337655e-37
HSPA4L	22824	broad.mit.edu	37	chr4	128722997	128722997	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cccattagatgagaaaccaaGaaatgtagtatttattgata	7	5	0	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:128722997G>C	uc003ifm.2	+	6	840	c.587G>C	c.(586-588)AGA>ACA	p.R196T	HSPA4L_uc010iny.1_Missense_Mutation_p.R155T|HSPA4L_uc011cgr.1_Missense_Mutation_p.R163T	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	196					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GAGAAACCAAGAAATGTAGTA	0.328													0	0	0	0.006122	0	15	13										C	128722997	G	C	128722997	3	2	78	1	0	0	0	0	1	0	0	0	7413	942	33	1	609	1	HSPA4L	4	128722997	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2481894	128722997	62431279	73	23484										
FGA	2243	broad.mit.edu	37	chr4	155506692	155506692	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaggagaagtgtggatacctCtgacagggcgagatttagca	14	6	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:155506692C>T	uc003iod.1	-	5	1947	c.1889G>A	c.(1888-1890)AGA>AAA	p.R630K	FGA_uc003ioe.1_Missense_Mutation_p.R630K|FGA_uc003iof.1_3'UTR	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	630	By similarity.|Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	gtggatacctctgaCAGGGCG	0.239													0	0	0	0.008871	0	19	51										T	155506692	C	T	155506692	3	4	78	1	0	0	0	0	1	0	0	0	5830	913	32	1	763	1	FGA	4	155506692	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	26783695	155506692	35647584	74	23485										
ODZ3	55714	broad.mit.edu	37	chr4	183710449	183710449	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gccagcatccagcgaggcacCactagcgagaaagtagatta	11	11	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:183710449C>T	uc003ivd.1	+	24	5545	c.5508C>T	c.(5506-5508)ACC>ACT	p.T1836T		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1836	YD 5.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGCGAGGCACCACTAGCGAGA	0.512													0	0	0	0.006214	0	7	43										T	183710449	C	T	183710449	2	4	78	1	0	0	0	0	0	0	0	1	10836	581	21	2		2	ODZ3	4	183710449	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	28203757	183710449	7443827	75	23486										
MARCH6	10299	broad.mit.edu	37	chr5	10390534	10390534	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctggtgtggttgagagagcaGatagtccatgggggagcacc	17	7	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:10390534G>C	uc003jet.1	+	6	681	c.498G>C	c.(496-498)CAG>CAC	p.Q166H	MARCH6_uc011cmu.1_Missense_Mutation_p.Q118H|MARCH6_uc003jeu.1_5'UTR|MARCH6_uc011cmv.1_Missense_Mutation_p.Q61H	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	166	Cytoplasmic (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TGAGAGAGCAGATAGTCCATG	0.488													0	0	0	0.01441	0	42	143										C	10390534	G	C	10390534	3	2	78	1	0	0	0	0	1	0	0	0	9305	933	33	1	520	1	MARCH6	5	10390534	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		10390534	170524726	76	23487										
OCLN	4950	broad.mit.edu	37	chr5	68805036	68805036	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcatgttcgaccaatgctctCtcagccagcctactcttttt	6	14	3	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:68805036C>G	uc003jwu.2	+	3	555	c.119C>G	c.(118-120)TCT>TGT	p.S40C	OCLN_uc003jwv.3_Missense_Mutation_p.S40C	NM_002538	NP_002529			occludin												0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CCAATGCTCTCTCAGCCAGCC	0.403													0	0	0	0.021022	0	36	81										G	68805036	C	G	68805036	3	3	78	1	0	0	0	0	1	0	0	0	10820	913	32	1	125	1	OCLN	5	68805036	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	58414502	68805036	112110224	77	23488										
ATP6AP1L	92270	broad.mit.edu	37	chr5	81608660	81608660	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cctgtgggaggtcacttttaTtgatttccaggtaataaact	9	7	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:81608660T>C	uc003khv.2	+	9	1687	c.362T>C	c.(361-363)ATT>ACT	p.I121T	ATP6AP1L_uc003khw.2_Missense_Mutation_p.I121T	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	121					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						GTCACTTTTATTGATTTCCAG	0.502											OREG0016689	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	9	38										C	81608660	T	C	81608660	3	2	78	1	0	0	0	0	1	0	0	0	1166	1493	52	5	372	5	ATP6AP1L	5	81608660	Missense_Mutation	SNP	T	TCGA-FD-A3NA-01A-11D-A21A-08	12803624	81608660	99306600	78	23489										
ARRDC3	57561	broad.mit.edu	37	chr5	90670966	90670966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cattcgggaagagcagttctCaatctcagcaaatatctgaa	8	9	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:90670966C>G	uc003kjz.2	-	5	883	c.643G>C	c.(643-645)GAG>CAG	p.E215Q		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	215					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		GAGCAGTTCTCAATCTCAGCA	0.388													0	0	0	0.009096	0	4	33										G	90670966	C	G	90670966	3	3	78	1	0	0	0	0	1	0	0	0	984	835	29	1	617	1	ARRDC3	5	90670966	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	9062306	90670966	90244294	79	23490										
SAR1B	51128	broad.mit.edu	37	chr5	133942733	133942733	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acttctaagggtcgggcattCagttctttcagagatatact	9	8	4	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:133942733C>G	uc003kzq.2	-	8	751	c.504G>C	c.(502-504)CTG>CTC	p.L168L	SAR1B_uc003kzr.2_Silent_p.L168L	NM_001033503	NP_001028675	Q9Y6B6	SAR1B_HUMAN	SAR1a gene homolog 2	168					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi cisterna membrane	GTP binding|GTPase activity|metal ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCGGGCATTCAGTTCTTTCA	0.403													0	0	0	0.007291	0	24	62										G	133942733	C	G	133942733	2	3	78	1	0	0	0	0	0	0	0	1	13840	813	29	1		1	SAR1B	5	133942733	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	43271767	133942733	46972527	80	23491										
PCDHB10	56126	broad.mit.edu	37	chr5	140572567	140572567	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaatatcagaaaatacagctGaagggacagcatttagacta	8	6	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:140572567G>A	uc003lix.2	+	1	616	c.442G>A	c.(442-444)GAA>AAA	p.E148K		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	148	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATACAGCTGAAGGGACAGC	0.413													0	0	0	0.00632	0	27	42										A	140572567	G	A	140572567	3	1	78	1	0	0	0	0	1	0	0	0	11535	1291	45	1	444	1	PCDHB10	5	140572567	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	6629834	140572567	40342693	81	23492										
NR3C1	2908	broad.mit.edu	37	chr5	142680325	142680325	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttatttttttctttgtttttCgagctgtgggtatttaaaca	7	4	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:142680325C>T	uc003lmz.2	-	5	1964	c.1472G>A	c.(1471-1473)CGA>CAA	p.R491Q	NR3C1_uc003lmy.2_Missense_Mutation_p.R492Q|NR3C1_uc003lna.2_Missense_Mutation_p.R491Q|NR3C1_uc003lnb.2_Missense_Mutation_p.R491Q|NR3C1_uc011dbk.1_Missense_Mutation_p.R94Q|NR3C1_uc003lnc.2_Missense_Mutation_p.R491Q|NR3C1_uc003lnd.2_Missense_Mutation_p.R491Q|NR3C1_uc003lne.2_Missense_Mutation_p.R491Q|NR3C1_uc003lnf.2_Missense_Mutation_p.R492Q	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	491	Hinge.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	CTTTGTTTTTCGAGCTGTGGG	0.348													0	0	0	0.004672	0	3	7										T	142680325	C	T	142680325	3	4	78	1	0	0	0	0	1	0	0	0	10630	884	31	1	933	1	NR3C1	5	142680325	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	2107758	142680325	38234935	82	23493										
FBXO38	81545	broad.mit.edu	37	chr5	147821699	147821699	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atggagagccagttgaagatGactacatttaattggtccct	10	7	0	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:147821699G>A	uc003lpf.1	+	22	3676	c.3556G>A	c.(3556-3558)GAC>AAC	p.D1186N	FBXO38_uc003lpg.1_Missense_Mutation_p.D1111N|FBXO38_uc003lph.2_Missense_Mutation_p.D941N	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	1186						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGAAGATGACTACATTTA	0.458													0	0	0	0.016723	0	12	80										A	147821699	G	A	147821699	3	1	78	1	0	0	0	0	1	0	0	0	5746	1290	45	1	3638	1	FBXO38	5	147821699	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	5141374	147821699	33093561	83	23494										
PPARD	5467	broad.mit.edu	37	chr6	35392554	35392554	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgcggccatcattctgtgtgGaggtgagtgagagtggggca	18	6	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:35392554G>C	uc003okm.2	+	7	1385	c.1076G>C	c.(1075-1077)GGA>GCA	p.G359A	PPARD_uc003okl.2_Missense_Mutation_p.G359A|PPARD_uc003okn.2_Missense_Mutation_p.G359A|PPARD_uc011dtb.1_Missense_Mutation_p.G320A|PPARD_uc011dtc.1_Missense_Mutation_p.G261A	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	359	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	ATTCTGTGTGGAGGTGAGTGA	0.562													0	0	0	0.008871	0	15	22										C	35392554	G	C	35392554	3	2	78	1	0	0	0	0	1	0	0	0	12298	1174	41	1	1111	1	PPARD	6	35392554	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		35392554	135722513	84	23495										
TDRD6	221400	broad.mit.edu	37	chr6	46657989	46657989	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aagactggagaaggagagcaGaaagccaagagagagaataa	14	4	0	6			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:46657989G>A	uc003oyj.2	+	1	2124	c.2124G>A	c.(2122-2124)CAG>CAA	p.Q708Q	TDRD6_uc010jze.2_Silent_p.Q702Q	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	708					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AAGGAGAGCAGAAAGCCAAGA	0.408													0	0	0	0.006122	0	15	24										A	46657989	G	A	46657989	2	1	78	1	0	0	0	0	0	0	0	1	15731	933	33	1		1	TDRD6	6	46657989	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	11265435	46657989	124457078	85	23496										
NT5E	4907	broad.mit.edu	37	chr6	86194979	86194979	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	caccttccaaagaggtgcctGctgggaagtacccattcata	9	12	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:86194979G>A	uc003pko.3	+	4	1334	c.778G>A	c.(778-780)GCT>ACT	p.A260T	NT5E_uc010kbr.2_Missense_Mutation_p.A260T	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	260					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	AGAGGTGCCTGCTGGGAAGTA	0.502													0	0	0	0.006214	0	9	55										A	86194979	G	A	86194979	3	1	78	1	0	0	0	0	1	0	0	0	10693	1319	46	2	792	2	NT5E	6	86194979	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	39536990	86194979	84920088	86	23497										
FOXO3	2309	broad.mit.edu	37	chr6	108984897	108984897	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gctgacgacagtccctcccaGctctccaagtggcctggcag	11	16	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:108984897G>A	uc003psk.2	+	3	1177	c.861G>A	c.(859-861)CAG>CAA	p.Q287Q	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Silent_p.Q287Q|FOXO3_uc011ean.1_Silent_p.Q67Q|FOXO3_uc010kdj.1_Silent_p.Q67Q	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	287					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		GTCCCTCCCAGCTCTCCAAGT	0.597													0	0	0	0.006122	0	12	18										A	108984897	G	A	108984897	2	1	78	1	0	0	0	0	0	0	0	1	6024	962	34	2		2	FOXO3	6	108984897	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	22789918	108984897	62130170	87	23498										
SESN1	27244	broad.mit.edu	37	chr6	109308772	109308772	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcatatagcgggtaatggctCtcagagcataaaggagttct	11	7	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:109308772C>G	uc003pst.3	-	10	1546	c.1454G>C	c.(1453-1455)AGA>ACA	p.R485T	SESN1_uc003psu.2_Missense_Mutation_p.R544T	NM_014454	NP_055269	Q9Y6P5	SESN1_HUMAN	sestrin 1	485					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				ovary(1)	1		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		GGTAATGGCTCTCAGAGCATA	0.398													0	0	0	0.00632	0	20	55										G	109308772	C	G	109308772	3	3	78	1	0	0	0	0	1	0	0	0	14124	913	32	1	28	1	SESN1	6	109308772	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	323875	109308772	61806295	88	23499										
COL10A1	1300	broad.mit.edu	37	chr6	116442382	116442382	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aggcctggcaagcctggtttCccaaagccaggaggccctgg	14	13	0	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:116442382C>T	uc003pwm.2	-	3	993	c.897G>A	c.(895-897)GGG>GGA	p.G299G	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	299	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		AGCCTGGTTTCCCAAAGCCAG	0.642													0	0	0	0.004482	0	8	27										T	116442382	C	T	116442382	2	4	78	1	0	0	0	0	0	0	0	1	3666	842	30	1		1	COL10A1	6	116442382	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	7133610	116442382	54672685	89	23500										
HDDC2	51020	broad.mit.edu	37	chr6	125621706	125621706	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtctttgttaagacggtcatCtttgatcaccatagccataa	7	9	4	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:125621706C>T	uc003qaa.1	-	2	388	c.184G>A	c.(184-186)GAT>AAT	p.D62N	HDDC2_uc003qab.1_RNA	NM_016063	NP_057147	Q7Z4H3	HDDC2_HUMAN	HD domain containing 2	62	HD.						metal ion binding|phosphoric diester hydrolase activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0186)		AGACGGTCATCTTTGATCACC	0.498													0	0	0	0.028581	0	15	61										T	125621706	C	T	125621706	3	4	78	1	0	0	0	0	1	0	0	0	7016	913	32	1	450	1	HDDC2	6	125621706	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	9179324	125621706	45493361	90	23501										
FNDC1	84624	broad.mit.edu	37	chr6	159653433	159653433	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cgcgtccacccagggcacctCtcatcgtccttccctgcctg	8	20	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:159653433C>G	uc010kjv.2	+	11	2089	c.1889C>G	c.(1888-1890)TCT>TGT	p.S630C	FNDC1_uc010kjw.1_Missense_Mutation_p.S515C	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	630						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAGGGCACCTCTCATCGTCCT	0.667													0	0	0	0.006122	0	12	96										G	159653433	C	G	159653433	3	3	78	1	0	0	0	0	1	0	0	0	5968	913	32	1	1931	1	FNDC1	6	159653433	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	34031727	159653433	11461634	91	23502										
WDR27	253769	broad.mit.edu	37	chr6	170013745	170013745	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gaggctgttgggttgtaaatGatgaaccctataattttaag	11	4	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:170013745G>A	uc003qwx.2	-	22	2751	c.2231C>T	c.(2230-2232)TCA>TTA	p.S744L	WDR27_uc003qwv.1_Intron|WDR27_uc010kkw.1_Missense_Mutation_p.S744L|WDR27_uc003qwy.2_Missense_Mutation_p.S617L			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	714	WD 8.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GGTTGTAAATGATGAACCCTA	0.423													0	0	0	0.014758	0	4	24										A	170013745	G	A	170013745	3	1	78	1	0	0	0	0	1	0	0	0	17281	1294	45	1	358	1	WDR27	6	170013745	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	10360312	170013745	1101322	92	23503										
AMZ1	155185	broad.mit.edu	37	chr7	2749415	2749415	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tctgcctgaggaagctgcagCatgtcctgggtttcaggctc	13	11	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:2749415C>A	uc003smr.1	+	6	1274	c.913C>A	c.(913-915)CAT>AAT	p.H305N	AMZ1_uc003sms.1_Missense_Mutation_p.A248E|AMZ1_uc011jwa.1_Missense_Mutation_p.H54N	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	305							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		GAAGCTGCAGCATGTCCTGGG	0.701											OREG0017838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.4624e-09	0.008871	2.59031e-09	15	31										A	2749415	C	A	2749415	3	1	78	1	0	0	0	0	1	0	0	0	596	710	25	4	931	4	AMZ1	7	2749415	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08		2749415	156389248	93	23504										
PLEKHA8	84725	broad.mit.edu	37	chr7	30094402	30094402	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acttgactcagtctggatcaGactcaagttgctctccggaa	9	11	5	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:30094402G>A	uc003tam.1	+	8	965	c.874G>A	c.(874-876)GAC>AAC	p.D292N	PLEKHA8_uc003tao.2_Missense_Mutation_p.D176N|PLEKHA8_uc003tap.1_Missense_Mutation_p.D292N|PLEKHA8_uc003tan.2_Missense_Mutation_p.D292N	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	292					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						GTCTGGATCAGACTCAAGTTG	0.383													0	0	0	0.021523	0	22	79										A	30094402	G	A	30094402	3	1	78	1	0	0	0	0	1	0	0	0	12062	942	33	1	904	1	PLEKHA8	7	30094402	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	27344987	30094402	129044261	94	23505										
MYO1G	64005	broad.mit.edu	37	chr7	45015119	45015119	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctgtggatgtgtcctccgatCgggtcccccttgaagtcaaa	11	12	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:45015119C>T	uc003tmh.2	-	4	672	c.528G>A	c.(526-528)CCG>CCA	p.P176P	MYO1G_uc003tmg.2_5'Flank|MYO1G_uc010kym.2_Silent_p.P61P|MYO1G_uc003tmi.1_Silent_p.P88P|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	176	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GTCCTCCGATCGGGTCCCCCT	0.607													0	0	0	0.01892	0	16	28										T	45015119	C	T	45015119	2	4	78	1	0	0	0	0	0	0	0	1	10074	871	31	1		1	MYO1G	7	45015119	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	14920717	45015119	114123544	95	23506										
EPHB4	2050	broad.mit.edu	37	chr7	100417263	100417263	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cccgttcaatgcagtgacctCaaaggtataggtgaagtcag	11	9	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:100417263C>G	uc003uwn.1	-	6	1704	c.1213G>C	c.(1213-1215)GAG>CAG	p.E405Q	EPHB4_uc003uwm.1_Missense_Mutation_p.E312Q|EPHB4_uc010lhj.1_Missense_Mutation_p.E405Q|EPHB4_uc011kkf.1_Missense_Mutation_p.E405Q|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Missense_Mutation_p.E405Q	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	405	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCAGTGACCTCAAAGGTATAG	0.622													0	0	0	0.024245	0	13	146										G	100417263	C	G	100417263	3	3	78	1	0	0	0	0	1	0	0	0	5177	835	29	1	1798	1	EPHB4	7	100417263	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	55402144	100417263	58721400	96	23507										
RELN	5649	broad.mit.edu	37	chr7	103202301	103202301	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atccctcgtcctgagcacatCcaagggcaccctgaggccag	10	16	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:103202301C>T	uc003vca.2	-	35	5470	c.5310G>A	c.(5308-5310)TGG>TGA	p.W1770*	RELN_uc010liz.2_Nonsense_Mutation_p.W1770*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1770	EGF-like 4.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGAGCACATCCAAGGGCACC	0.473													0	0	0	0.007835	0	30	48										T	103202301	C	T	103202301	4	4	78	1	0	0	0	0	0	1	0	0	13220	856	30	1	5196	1	RELN	7	103202301	Nonsense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	2785038	103202301	55936362	97	23508										
IFRD1	3475	broad.mit.edu	37	chr7	112096991	112096991	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cgaagacaaggcaagcagctCttgaaggtattaaaaatgca	10	7	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:112096991C>A	uc003vgh.2	+	5	750	c.307C>A	c.(307-309)CTT>ATT	p.L103I	IFRD1_uc011kmn.1_Missense_Mutation_p.L53I|IFRD1_uc003vgi.2_Missense_Mutation_p.L103I|IFRD1_uc003vgj.2_Missense_Mutation_p.L103I|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.L53I	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	103					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						GCAAGCAGCTCTTGAAGGTAT	0.338													1	0	0.00024832	0.009096	0.000257871	3	39										A	112096991	C	A	112096991	3	1	78	1	0	0	0	0	1	0	0	0	7553	913	32	3	321	3	IFRD1	7	112096991	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	8894690	112096991	47041672	98	23509										
FLNC	2318	broad.mit.edu	37	chr7	128488646	128488646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcaaggtcctcccagctcatGatgccagcaaggtgcgggcc	12	14	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:128488646G>C	uc003vnz.3	+	27	4821	c.4612G>C	c.(4612-4614)GAT>CAT	p.D1538H	FLNC_uc003voa.3_Missense_Mutation_p.D1538H	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1538	Filamin 14.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CCCAGCTCATGATGCCAGCAA	0.642													0	0	0	0.01441	0	54	254										C	128488646	G	C	128488646	3	2	78	1	0	0	0	0	1	0	0	0	5935	1290	45	1	4718	1	FLNC	7	128488646	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	16391655	128488646	30650017	99	23510										
ZNF425	155054	broad.mit.edu	37	chr7	148801424	148801424	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tggaccttcaggtgctgcgtGagccgcgactgctgagaaaa	14	10	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:148801424G>A	uc003wfj.2	-	4	1612	c.1539C>T	c.(1537-1539)CTC>CTT	p.L513L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	513	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GGTGCTGCGTGAGCCGCGACT	0.637													0	0	0	0.016723	0	9	33										A	148801424	G	A	148801424	2	1	78	1	0	0	0	0	0	0	0	1	17896	1277	45	1		1	ZNF425	7	148801424	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	20312778	148801424	10337239	100	23511										
MLL3	58508	broad.mit.edu	37	chr7	151945127	151945127	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aagagctgaagggtaattatGcagcatgtcatgcgaaggca	13	6	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:151945127G>C	uc003wla.2	-	14	2611	c.2392C>G	c.(2392-2394)CAT>GAT	p.H798D		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	798					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGGTAATTATGCAGCATGTCA	0.443			N		medulloblastoma								0	0	0	0.019004	0	25	552										C	151945127	G	C	151945127	3	2	78	1	0	0	0	0	1	0	0	0	9622	1319	46	4	12527	4	MLL3	7	151945127	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	3143703	151945127	7193536	101	23512										
IKBKB	3551	broad.mit.edu	37	chr8	42183487	42183487	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcttttgattttgtcccctaGagcaaggtccgtggtcctgt	10	10	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:42183487G>C	uc003xow.1	+	20	2164	c.1987_splice	c.e20-1	p.S663_splice	IKBKB_uc010lxj.1_Splice_Site_p.S440_splice|IKBKB_uc003xox.1_Splice_Site_p.S384_splice|IKBKB_uc011lcp.1_Splice_Site|IKBKB_uc011lcq.1_Splice_Site_p.S661_splice|IKBKB_uc010lxi.1_Splice_Site|IKBKB_uc011lcr.1_Splice_Site_p.S604_splice	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta						anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TTGTCCCCTAGAGCAAGGTCC	0.522													0	0	0	0.01441	0	44	157										C	42183487	G	C	42183487	5	2	78	1	0	0	0	0	0	0	1	0	7611	956	33	1	2060	1	IKBKB	8	42183487	Splice_Site	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		42183487	104180535	102	23513										
LRRCC1	85444	broad.mit.edu	37	chr8	86050700	86050700	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cggaaagagacaaaagtattGaactacaaaagtaagcatta	8	5	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:86050700G>C	uc003ycw.2	+	17	2984	c.2830G>C	c.(2830-2832)GAA>CAA	p.E944Q	LRRCC1_uc003ycx.2_Missense_Mutation_p.E851Q|LRRCC1_uc003ycy.2_Missense_Mutation_p.E924Q	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	944					cell division|mitosis	centriole|nucleus					0						CAAAAGTATTGAACTACAAAA	0.333													0	0	0	0.028581	0	13	20										C	86050700	G	C	86050700	3	2	78	1	0	0	0	0	1	0	0	0	9026	1291	45	1	2896	1	LRRCC1	8	86050700	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	43867213	86050700	60313322	103	23514										
ESRP1	54845	broad.mit.edu	37	chr8	95655543	95655543	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcttgcagtttaaccagtcaGtgagcaatgaactgaatatt	8	7	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:95655543G>A	uc003ygq.3	+	3	457	c.274G>A	c.(274-276)GTG>ATG	p.V92M	ESRP1_uc003ygr.3_Missense_Mutation_p.V92M|ESRP1_uc003ygs.3_Missense_Mutation_p.V92M|ESRP1_uc003ygt.3_Missense_Mutation_p.V92M|ESRP1_uc003ygu.3_Missense_Mutation_p.V92M|ESRP1_uc003ygv.2_5'Flank|ESRP1_uc003ygw.2_5'Flank	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	92					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TAACCAGTCAGTGAGCAATGA	0.453													0	0	0	0.014758	0	4	87										A	95655543	G	A	95655543	3	1	78	1	0	0	0	0	1	0	0	0	5258	1029	36	2	284	2	ESRP1	8	95655543	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	9604843	95655543	50708479	104	23515										
PLEKHF2	79666	broad.mit.edu	37	chr8	96166849	96166849	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gctctgaaaagagatttcttCttcccagccagtcctctaag	7	12	4	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:96166849C>T	uc003yhn.1	+	2	824	c.577C>T	c.(577-579)CTT>TTT	p.L193F		NM_024613	NP_078889	Q9H8W4	PKHF2_HUMAN	phafin 2	193	FYVE-type.					transport vesicle	metal ion binding|protein binding			ovary(2)	2	Breast(36;3.18e-05)					GAGATTTCTTCTTCCCAGCCA	0.507													0	0	0	0.01441	0	51	98										T	96166849	C	T	96166849	3	4	78	1	0	0	0	0	1	0	0	0	12067	913	32	1	579	1	PLEKHF2	8	96166849	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	511306	96166849	50197173	105	23516										
RIMS2	9699	broad.mit.edu	37	chr8	104897909	104897909	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gatccatgctgaagtgtcccGagcacggcatgagagaaggc	14	10	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:104897909G>A	uc003yls.2	+	2	657	c.416G>A	c.(415-417)CGA>CAA	p.R139Q	RIMS2_uc003ylp.2_Missense_Mutation_p.R361Q|RIMS2_uc003ylw.2_Missense_Mutation_p.R169Q|RIMS2_uc003ylq.2_Missense_Mutation_p.R169Q|RIMS2_uc003ylr.2_Missense_Mutation_p.R169Q	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	392					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAAGTGTCCCGAGCACGGCAT	0.478										HNSCC(12;0.0054)			0	0	0	0.024245	0	12	21										A	104897909	G	A	104897909	3	1	78	1	0	0	0	0	1	0	0	0	13368	1058	37	1	1222	1	RIMS2	8	104897909	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	8731060	104897909	41466113	106	23517										
CSMD3	114788	broad.mit.edu	37	chr8	113241090	113241090	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttgtaccatgaggttgatttGaagaatttgaaccttctgac	9	6	1	6			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:113241090G>T	uc003ynu.2	-	70	11018	c.10859C>A	c.(10858-10860)TCA>TAA	p.S3620*	CSMD3_uc003yns.2_Nonsense_Mutation_p.S2822*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.S3580*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.S3451*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3620	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGTTGATTTGAAGAATTTGA	0.279										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	1.20859e-23	0.007413	1.32292e-23	15	18										T	113241090	G	T	113241090	4	4	78	1	0	0	0	0	0	1	0	0	3946	1294	45	3	272	3	CSMD3	8	113241090	Nonsense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	8343181	113241090	33122932	107	23518										
ENPP2	5168	broad.mit.edu	37	chr8	120620215	120620215	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgcttggtggctgtaatccaTagctaatgaggaaaatataa	10	5	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:120620215T>C	uc003yot.1	-	9	866	c.780A>G	c.(778-780)CTA>CTG	p.L260L	ENPP2_uc003yos.1_Silent_p.L260L|ENPP2_uc010mdd.1_Silent_p.L260L	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	260					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CTGTAATCCATAGCTAATGAG	0.318													0	0	0	0.006122	0	15	12										C	120620215	T	C	120620215	2	2	78	1	0	0	0	0	0	0	0	1	5130	1393	49	5		5	ENPP2	8	120620215	Silent	SNP	T	TCGA-FD-A3NA-01A-11D-A21A-08	7379125	120620215	25743807	108	23519										
MAPK15	225689	broad.mit.edu	37	chr8	144803789	144803789	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctccaaactgctctcctaggGaatggggaaaggccccctgg	12	13	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:144803789G>T	uc003yzj.2	+	12	1316	c.1275G>T	c.(1273-1275)GGG>GGT	p.G425G		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	425					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCTCCTAGGGAATGGGGAAA	0.662													1	0	2.41358e-16	0.01441	2.59513e-16	60	64										T	144803789	G	T	144803789	2	4	78	1	0	0	0	0	0	0	0	1	9277	1161	41	3		3	MAPK15	8	144803789	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	24183574	144803789	1560233	109	23520										
SLC1A1	6505	broad.mit.edu	37	chr9	4574009	4574009	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctttacatggccacagtcctGactgggtatgtcagactcaa	9	11	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr9:4574009G>C	uc003zij.1	+	8	1106	c.870G>C	c.(868-870)CTG>CTC	p.L290L	C9orf68_uc003zik.2_Intron	NM_004170	NP_004161	P43005	EAA3_HUMAN	solute carrier family 1, member 1	290	Helical; (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CCACAGTCCTGACTGGGTATG	0.458													0	0	0	0.011902	0	44	47										C	4574009	G	C	4574009	2	2	78	1	0	0	0	0	0	0	0	1	14431	1277	45	1		1	SLC1A1	9	4574009	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		4574009	136639422	110	23521										
C9orf43	257169	broad.mit.edu	37	chr9	116190476	116190476	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gacatgaagcagcagcagcaGatggaaaaaggaaccacttc	11	9	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr9:116190476G>C	uc004bho.3	+	12	1476	c.1080G>C	c.(1078-1080)CAG>CAC	p.Q360H	C9orf43_uc004bhp.2_Missense_Mutation_p.Q360H	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	360											0						AGCAGCAGCAGATGGAAAAAG	0.373													0	0	0	0.004672	0	3	127										C	116190476	G	C	116190476	3	2	78	1	0	0	0	0	1	0	0	0	2483	933	33	1	1122	1	C9orf43	9	116190476	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	111616467	116190476	25022955	111	23522										
C10orf18	54906	broad.mit.edu	37	chr10	5798670	5798670	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tacactaatcatcatcatcaGaaatgaagatatatcatcac	3	9	6	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:5798670G>A	uc001iij.2	+	16	7326	c.6701G>A	c.(6700-6702)AGA>AAA	p.R2234K	C10orf18_uc001iik.2_Missense_Mutation_p.R1078K	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2234										ovary(1)|central_nervous_system(1)	2						ATCATCATCAGAAATGAAGAT	0.393													0	0	0	0.027356	0	25	46										A	5798670	G	A	5798670	3	1	78	1	0	0	0	0	1	0	0	0	1596	942	33	1	6751	1	C10orf18	10	5798670	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		5798670	129736077	112	23523										
WAC	51322	broad.mit.edu	37	chr10	28897274	28897274	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acctcccttacttcaggaccCaaatcttcttagacaattgc	4	14	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:28897274C>T	uc001iuf.2	+	8	1164	c.1079C>T	c.(1078-1080)CCA>CTA	p.P360L	WAC_uc001iud.2_Missense_Mutation_p.P315L|WAC_uc001iue.2_Missense_Mutation_p.P50L|WAC_uc009xlb.2_Missense_Mutation_p.P315L|WAC_uc001iug.2_Missense_Mutation_p.P257L|WAC_uc001iuh.2_Missense_Mutation_p.P315L	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	360					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						CTTCAGGACCCAAATCTTCTT	0.448													0	0	0	0.010729	0	11	11										T	28897274	C	T	28897274	3	4	78	1	0	0	0	0	1	0	0	0	17244	594	21	2	1109	2	WAC	10	28897274	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	23098604	28897274	106637473	113	23524										
CHAT	1103	broad.mit.edu	37	chr10	50873030	50873030	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcagtctgctgccgcctactGagagcaagccattggcaaca	11	13	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:50873030G>A	uc001jhz.2	+	15	2338	c.2185G>A	c.(2185-2187)GAG>AAG	p.E729K	CHAT_uc001jhv.1_Missense_Mutation_p.E611K|CHAT_uc001jhx.1_Missense_Mutation_p.E611K|CHAT_uc001jhy.1_Missense_Mutation_p.E611K|CHAT_uc001jia.2_Missense_Mutation_p.E611K|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	729					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GCCGCCTACTGAGAGCAAGCC	0.522													0	0	0	0.01441	0	54	60										A	50873030	G	A	50873030	3	1	78	1	0	0	0	0	1	0	0	0	3313	1291	45	1	2287	1	CHAT	10	50873030	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	21975756	50873030	84661717	114	23525										
HECTD2	143279	broad.mit.edu	37	chr10	93252132	93252132	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acccggaaaagagccgatttGaaaaagaagttaaaagttac	9	6	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:93252132G>C	uc001khl.2	+	13	1423	c.1323G>C	c.(1321-1323)TTG>TTC	p.L441F	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Missense_Mutation_p.L445F|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_Missense_Mutation_p.L30F|HECTD2_uc001khn.1_Missense_Mutation_p.L91F	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	441	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						GAGCCGATTTGAAAAAGAAGT	0.348													0	0	0	0.013537	0	12	14										C	93252132	G	C	93252132	3	2	78	1	0	0	0	0	1	0	0	0	7040	1281	45	1	1397	1	HECTD2	10	93252132	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	42379102	93252132	42282615	115	23526										
MYOF	26509	broad.mit.edu	37	chr10	95123738	95123738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cgcatccgtgtaggtgtcctCggccggcttccagtcgcccc	12	17	0	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:95123738C>T	uc001kin.2	-	27	2971	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	MYOF_uc001kio.2_Missense_Mutation_p.E937K|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	950	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TAGGTGTCCTCGGCCGGCTTC	0.612													0	0	0	0.01441	0	70	63										T	95123738	C	T	95123738	3	4	78	1	0	0	0	0	1	0	0	0	10089	893	31	1	3449	1	MYOF	10	95123738	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	1871606	95123738	40411009	116	23527										
MUC6	4588	broad.mit.edu	37	chr11	1017507	1017507	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgggggtgatgctggtggtaGaagttgaggtgacttcagga	19	3	1	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:1017507G>A	uc001lsw.2	-	31	5345	c.5294C>T	c.(5293-5295)TCT>TTT	p.S1765F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1765	Thr-rich.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGGTGGTAGAAGTTGAGGT	0.577													0	0	0	0.01892	0	19	649										A	1017507	G	A	1017507	3	1	78	1	0	0	0	0	1	0	0	0	9980	942	33	1	2037	1	MUC6	11	1017507	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		1017507	133989009	117	23528										
PDE3B	5140	broad.mit.edu	37	chr11	14839736	14839736	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttaatttttaaaggtgttttGtccagtctgagtcctgtgaa	9	5	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:14839736G>A	uc001mln.2	+	6	1883	c.1530G>A	c.(1528-1530)TTG>TTA	p.L510L	PDE3B_uc010rcr.1_Silent_p.L459L	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	510					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						AAGGTGTTTTGTCCAGTCTGA	0.323													0	0	0	0.004672	0	3	11										A	14839736	G	A	14839736	2	1	78	1	0	0	0	0	0	0	0	1	11638	1368	48	2		2	PDE3B	11	14839736	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	13822229	14839736	120166780	118	23529										
OR5W2	390148	broad.mit.edu	37	chr11	55681259	55681259	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcattttatcttgatctagaGaataggaagaacttggccgg	10	6	3	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:55681259G>A	uc010rir.1	-	1	800	c.800C>T	c.(799-801)TCT>TTT	p.S267F		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTGATCTAGAGAATAGGAAGA	0.438													0	0	0	0.021553	0	6	36										A	55681259	G	A	55681259	3	1	78	1	0	0	0	0	1	0	0	0	11185	942	33	1	134	1	OR5W2	11	55681259	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	40841523	55681259	79325257	119	23530										
SCGB2A1	4246	broad.mit.edu	37	chr11	61978051	61978051	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaccagtcacatagaactctGaaaaactttggactgatgat	7	8	2	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:61978051G>A	uc001nta.2	+	2	286	c.222G>A	c.(220-222)CTG>CTA	p.L74L		NM_002407	NP_002398	O75556	SG2A1_HUMAN	secretoglobin, family 2A, member 1 precursor	74						extracellular region	androgen binding				0						ATAGAACTCTGAAAAACTTTG	0.418													0	0	0	0.00499	0	15	41										A	61978051	G	A	61978051	2	1	78	1	0	0	0	0	0	0	0	1	13899	1277	45	1		1	SCGB2A1	11	61978051	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	6296792	61978051	73028465	120	23531										
SLC22A10	387775	broad.mit.edu	37	chr11	63072221	63072221	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcagcactggctcccctcttGatgaccttaacggtattttt	8	12	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:63072221G>C	uc009yor.2	+	9	1666	c.1458G>C	c.(1456-1458)TTG>TTC	p.L486F	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_3'UTR	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	486	Helical; (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CTCCCCTCTTGATGACCTTAA	0.408													0	0	0	0.010729	0	11	68										C	63072221	G	C	63072221	3	2	78	1	0	0	0	0	1	0	0	0	14441	1281	45	1	1492	1	SLC22A10	11	63072221	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	1094170	63072221	71934295	121	23532										
C2CD3	26005	broad.mit.edu	37	chr11	73814325	73814325	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaaatctttcccatctggcaCcatcaacagcacatgcaaca	4	14	3	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:73814325C>T	uc001ouu.2	-	14	2658	c.2431G>A	c.(2431-2433)GTG>ATG	p.V811M		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	811						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CCATCTGGCACCATCAACAGC	0.413													0	0	0	0.01892	0	23	105										T	73814325	C	T	73814325	3	4	78	1	0	0	0	0	1	0	0	0	2154	507	18	2	3532	2	C2CD3	11	73814325	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	10742104	73814325	61192191	122	23533										
PGM2L1	283209	broad.mit.edu	37	chr11	74053678	74053678	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acaagaaataggaagtttttGaaatatgataaccatatctg	7	4	1	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:74053678G>A	uc001ovb.1	-	12	1756	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L		NM_173582	NP_775853	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	487					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)					GGAAGTTTTTGAAATATGATA	0.289													0	0	0	0.016723	0	9	37										A	74053678	G	A	74053678	3	1	78	1	0	0	0	0	1	0	0	0	11799	1294	45	1	420	1	PGM2L1	11	74053678	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	239353	74053678	60952838	123	23534										
INTS4	92105	broad.mit.edu	37	chr11	77669853	77669853	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgcagcactgcgcacttgttCatagtcatcagagagtaatt	9	9	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:77669853C>T	uc001oys.2	-	7	764	c.736G>A	c.(736-738)GAA>AAA	p.E246K	INTS4_uc001oyt.2_RNA|INTS4_uc001oyu.1_Missense_Mutation_p.E246K	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	246	HEAT 4.				snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CGCACTTGTTCATAGTCATCA	0.428													0	0	0	0.001984	0	6	31										T	77669853	C	T	77669853	3	4	78	1	0	0	0	0	1	0	0	0	7780	835	29	1	2223	1	INTS4	11	77669853	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	3616175	77669853	57336663	124	23535										
SYTL2	54843	broad.mit.edu	37	chr11	85445049	85445049	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gatttatctttgggttcattGatggttggtgaattctccat	10	5	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:85445049G>C	uc010rth.1	-	6	1596	c.1320C>G	c.(1318-1320)ATC>ATG	p.I440M	SYTL2_uc010rtg.1_Missense_Mutation_p.I441M|SYTL2_uc010rti.1_Missense_Mutation_p.I440M|SYTL2_uc010rtj.1_Missense_Mutation_p.I392M|SYTL2_uc001pbf.3_Missense_Mutation_p.I440M|SYTL2_uc010rtf.1_Missense_Mutation_p.I298M	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	440					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGGTTCATTGATGGTTGGTG	0.383													0	0	0	0.01441	0	39	80										C	85445049	G	C	85445049	3	2	78	1	0	0	0	0	1	0	0	0	15480	1280	45	1	4017	1	SYTL2	11	85445049	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	7775196	85445049	49561467	125	23536										
NAALAD2	10003	broad.mit.edu	37	chr11	89885588	89885588	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cttcctggaactgcagcccaGagaggaaatgtgttaaattt	10	8	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:89885588G>A	uc001pdf.3	+	6	841	c.732G>A	c.(730-732)CAG>CAA	p.Q244Q	NAALAD2_uc009yvx.2_Silent_p.Q244Q|NAALAD2_uc009yvy.2_Silent_p.Q244Q|NAALAD2_uc001pdd.2_Silent_p.Q244Q|NAALAD2_uc001pde.2_Silent_p.Q244Q	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	244	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CTGCAGCCCAGAGAGGAAATG	0.473													0	0	0	0.006122	0	14	72										A	89885588	G	A	89885588	2	1	78	1	0	0	0	0	0	0	0	1	10128	933	33	1		1	NAALAD2	11	89885588	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	4440539	89885588	45120928	126	23537										
CASP4	837	broad.mit.edu	37	chr11	104815563	104815563	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agctttggcccttggagtttCaaatgattgctgtacctgaa	10	8	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:104815563C>G	uc001pid.1	-	8	1124	c.1051G>C	c.(1051-1053)GAA>CAA	p.E351Q	CASP4_uc001pib.1_Missense_Mutation_p.E295Q|CASP4_uc009yxg.1_Missense_Mutation_p.E260Q	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	351					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		CTTGGAGTTTCAAATGATTGC	0.403													0	0	0	0.001984	0	5	27										G	104815563	C	G	104815563	3	3	78	1	0	0	0	0	1	0	0	0	2673	835	29	1	86	1	CASP4	11	104815563	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	14929975	104815563	30190953	127	23538										
C11orf63	79864	broad.mit.edu	37	chr11	122775122	122775123	+	Frame_Shift_Ins	INS	-	-	A													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cttatcttcaacttcacaatINSaaaaaaagaggggaatctca							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:122775122_122775123insA	uc001pym.2	+	3	1131_1132	c.834_835insA	c.(832-837)AATAAAfs	p.N278fs	C11orf63_uc001pyl.1_Frame_Shift_Ins_p.N278fs	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	278_279										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AACTTCACAATAAAAAAAGAGG	0.406																		86	153	---	---								A	122775123	-	A	122775122	7	5	78	1	0	1	1	0	0	0	0	0	1654	1403	49	0	840	0	C11orf63	11	122775122	Frame_Shift_Ins	INS	-	TCGA-FD-A3NA-01A-11D-A21A-08	17959559	122775122	12231394	128	23539										
GLB1L3	112937	broad.mit.edu	37	chr11	134180464	134180464	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	actggccctggtgtcttgcaGactatgatgcagtgctcacg	12	11	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:134180464G>C	uc009zdf.2	+	12	1460	c.1100_splice	c.e12-1	p.D367_splice	GLB1L3_uc010scu.1_3'UTR|GLB1L3_uc001qho.3_Splice_Site	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3						carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GTGTCTTGCAGACTATGATGC	0.522													0	0	0	0.00308	0	6	17										C	134180464	G	C	134180464	5	2	78	1	0	0	0	0	0	0	1	0	6430	956	33	1	1145	1	GLB1L3	11	134180464	Splice_Site	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	11405342	134180464	826052	129	23540										
CHD4	1108	broad.mit.edu	37	chr12	6705273	6705273	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggtaagtcccgccacttgatCaagtagtggacgtggccctt	12	11	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:6705273C>G	uc001qpo.2	-	13	2087	c.1923G>C	c.(1921-1923)TTG>TTC	p.L641F	CHD4_uc001qpn.2_Missense_Mutation_p.L634F|CHD4_uc001qpp.2_Missense_Mutation_p.L638F	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	641	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCACTTGATCAAGTAGTGGA	0.507													0	0	0	0.013726	0	31	75										G	6705273	C	G	6705273	3	3	78	1	0	0	0	0	1	0	0	0	3327	825	29	1	3927	1	CHD4	12	6705273	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08		6705273	127146622	130	23541										
CHD4	1108	broad.mit.edu	37	chr12	6705294	6705294	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aagtagtggacgtggcccttCttgtccacactgcaagtcca	10	12	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:6705294C>G	uc001qpo.2	-	13	2066	c.1902G>C	c.(1900-1902)AAG>AAC	p.K634N	CHD4_uc001qpn.2_Missense_Mutation_p.K627N|CHD4_uc001qpp.2_Missense_Mutation_p.K631N	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	634	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CGTGGCCCTTCTTGTCCACAC	0.507													0	0	0	0.007291	0	27	65										G	6705294	C	G	6705294	3	3	78	1	0	0	0	0	1	0	0	0	3327	912	32	1	3948	1	CHD4	12	6705294	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	21	6705294	127146601	131	23542										
CD163	9332	broad.mit.edu	37	chr12	7640120	7640120	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tcctcctggggtagaaagggCaactccacatttaagctgct	10	11	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:7640120C>A	uc001qsz.3	-	8	2013	c.1885G>T	c.(1885-1887)GCC>TCC	p.A629S	CD163_uc001qta.3_Missense_Mutation_p.A629S|CD163_uc009zfw.2_Missense_Mutation_p.A662S	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	629	SRCR 6.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						GTAGAAAGGGCAACTCCACAT	0.507													1	0	2.61193e-14	0.009535	2.79603e-14	28	116										A	7640120	C	A	7640120	3	1	78	1	0	0	0	0	1	0	0	0	2967	710	25	4	1621	4	CD163	12	7640120	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	934826	7640120	126211775	132	23543										
APOBEC1	339	broad.mit.edu	37	chr12	7805382	7805382	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cagacaggcctctttacgaaGttctctggggtcatagaaga	11	9	3	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:7805382G>T	uc001qtb.2	-	3	128	c.94C>A	c.(94-96)CTT>ATT	p.L32I	APOBEC1_uc001qtc.2_5'UTR|APOBEC1_uc010sgf.1_Missense_Mutation_p.L32I	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	32					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						TCTTTACGAAGTTCTCTGGGG	0.478													1	0	2.24059e-21	0.00632	2.44154e-21	20	54										T	7805382	G	T	7805382	3	4	78	1	0	0	0	0	1	0	0	0	787	1029	36	4	628	4	APOBEC1	12	7805382	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	165262	7805382	126046513	133	23544										
PKP2	5318	broad.mit.edu	37	chr12	32977077	32977077	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	catcgcttttctcccatcagCgccagcagaactcatgtttc	6	15	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:32977077C>T	uc001rlj.3	-	8	1823	c.1708G>A	c.(1708-1710)GCT>ACT	p.A570T	PKP2_uc001rlk.3_Missense_Mutation_p.A526T|PKP2_uc010skj.1_Missense_Mutation_p.A526T	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	570					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTCCCATCAGCGCCAGCAGAA	0.413													0	0	0	0.021523	0	23	40										T	32977077	C	T	32977077	3	4	78	1	0	0	0	0	1	0	0	0	11985	768	27	2	965	2	PKP2	12	32977077	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	25171695	32977077	100874818	134	23545										
KRT80	144501	broad.mit.edu	37	chr12	52574698	52574698	+	Nonsense_Mutation	SNP	G	G	A													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcaggctaccttcttcagctGaacaaaggtgaactccatgt							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:52574698G>A	uc001rzx.2	-	3	657	c.559C>T	c.(559-561)CAG>TAG	p.Q187*	KRT80_uc001rzw.2_Nonsense_Mutation_p.Q124*|KRT80_uc001rzy.2_Nonsense_Mutation_p.Q187*	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	187	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		TTCTTCAGCTGAACAAAGGTG	0.582													0	0	0	0.007291	0	24	40										A	52574698	G	A	52574698	4	1	78	1	0	0	0	0	0	1	0	0	8494	1299	45	1	862	1	KRT80	12	52574698	Nonsense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	19597621	52574698	81277197	135	23546	118	2								
KRT80	144501	broad.mit.edu	37	chr12	52574708	52574708	+	Silent	SNP	G	G	A													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttcttcagctgaacaaaggtGaactccatgtctgtgcgctt							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:52574708G>A	uc001rzx.2	-	3	647	c.549C>T	c.(547-549)TTC>TTT	p.F183F	KRT80_uc001rzw.2_Silent_p.F120F|KRT80_uc001rzy.2_Silent_p.F183F	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	183	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		GAACAAAGGTGAACTCCATGT	0.592													0	0	0	0.008361	0	24	43										A	52574708	G	A	52574708	2	1	78	1	0	0	0	0	0	0	0	1	8494	1281	45	1		1	KRT80	12	52574708	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	10	52574708	81277187	136	23547	118	2								
OR9K2	441639	broad.mit.edu	37	chr12	55523876	55523876	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	attgaacccaaggctatgatCaacttctggtctgaaaacaa	7	9	3	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:55523876C>T	uc010spe.1	+	1	324	c.324C>T	c.(322-324)ATC>ATT	p.I108I		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	108	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						AGGCTATGATCAACTTCTGGT	0.453													0	0	0	0.028581	0	16	64										T	55523876	C	T	55523876	2	4	78	1	0	0	0	0	0	0	0	1	11254	816	29	1		1	OR9K2	12	55523876	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	2949168	55523876	78328019	137	23548										
PAN2	9924	broad.mit.edu	37	chr12	56721825	56721825	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agaagcgatttgtctgtctcAtgatggtgactccaggcgtc	12	9	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:56721825A>T	uc001skx.2	-	5	978	c.605T>A	c.(604-606)ATG>AAG	p.M202K	PAN2_uc001skz.2_Missense_Mutation_p.M202K|PAN2_uc001sky.2_Missense_Mutation_p.M202K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	202					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGTCTGTCTCATGATGGTGAC	0.507													0	0	0	0.001984	0	6	33										T	56721825	A	T	56721825	3	4	78	1	0	0	0	0	1	0	0	0	11414	217	8	5	3091	5	PAN2	12	56721825	Missense_Mutation	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08	1197949	56721825	77130070	138	23549										
MON2	23041	broad.mit.edu	37	chr12	62986494	62986494	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cttttaaggatttcatgcagCcaccagcatccagagttcaa	7	11	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:62986494C>G	uc001sre.2	+	35	5510	c.5119C>G	c.(5119-5121)CCA>GCA	p.P1707A	MON2_uc009zqj.2_3'UTR|MON2_uc010ssl.1_Missense_Mutation_p.P1635A|MON2_uc010ssm.1_Missense_Mutation_p.P1678A|MON2_uc010ssn.1_Missense_Mutation_p.P1701A|MON2_uc001srf.2_Missense_Mutation_p.P1470A|MON2_uc001srg.2_Missense_Mutation_p.P576A	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1708					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTTCATGCAGCCACCAGCATC	0.393													0	0	0	0.00632	0	23	42										G	62986494	C	G	62986494	3	3	78	1	0	0	0	0	1	0	0	0	9700	739	26	4	5257	4	MON2	12	62986494	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	6264669	62986494	70865401	139	23550										
DOCK9	23348	broad.mit.edu	37	chr13	99459962	99459962	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	attttcagaaccaaatttatCcgagtacagtttaaggagtc	7	7	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr13:99459962C>G	uc001vnt.2	-	50	5567	c.5512G>C	c.(5512-5514)GAT>CAT	p.D1838H	DOCK9_uc001vnw.2_Missense_Mutation_p.D1837H|DOCK9_uc001vnq.2_Missense_Mutation_p.D385H|DOCK9_uc001vnr.2_Missense_Mutation_p.D467H|DOCK9_uc010tin.1_Missense_Mutation_p.D456H|DOCK9_uc001vns.2_Missense_Mutation_p.D373H|DOCK9_uc010tio.1_Missense_Mutation_p.D493H|DOCK9_uc010tip.1_Missense_Mutation_p.D534H	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1838	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCAAATTTATCCGAGTACAGT	0.373													0	0	0	0.008291	0	9	39										G	99459962	C	G	99459962	3	3	78	1	0	0	0	0	1	0	0	0	4694	855	30	1	725	1	DOCK9	13	99459962	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08		99459962	15709916	140	23551										
SOX1	6656	broad.mit.edu	37	chr13	112722081	112722083	+	In_Frame_Del	DEL	GGC	GGC	-													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcggcgggggcggaggcgggGgcggcggcggcggcgggggc							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr13:112722081_112722083delGGC	uc001vsb.1	+	1	169_171	c.109_111delGGC	c.(109-111)GGCdel	p.G43del		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	43	Poly-Gly.				chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		cggaggcgggggcggcggcggcg	0.552																		5	10	---	---								-	112722083	GGC	-	112722081	7	5	78	1	0	1	0	1	0	0	0	0	14940	1232	43	0	111	0	SOX1	13	112722081	In_Frame_Del	DEL	GGC	TCGA-FD-A3NA-01A-11D-A21A-08	13262119	112722081	2447797	141	23552										
FBN1	2200	broad.mit.edu	37	chr15	48779383	48779383	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcacaggtgtgcactcagctCacattcattgatgtctgtcg	10	11	4	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:48779383C>T	uc001zwx.1	-	29	3806	c.3478G>A	c.(3478-3480)GAG>AAG	p.E1160K		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1160	EGF-like 18; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCACTCAGCTCACATTCATTG	0.468													0	0	0	0.008291	0	7	63										T	48779383	C	T	48779383	3	4	78	1	0	0	0	0	1	0	0	0	5702	835	29	1	5289	1	FBN1	15	48779383	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08		48779383	53752009	142	23553										
FBN1	2200	broad.mit.edu	37	chr15	48888548	48888548	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttggggccacacaccttcctCcattgagacagccactttca	7	15	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:48888548C>G	uc001zwx.1	-	6	798	c.470G>C	c.(469-471)GGA>GCA	p.G157A		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	157	EGF-like 3.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACACCTTCCTCCATTGAGACA	0.418													0	0	0	0.009096	0	3	60										G	48888548	C	G	48888548	3	3	78	1	0	0	0	0	1	0	0	0	5702	855	30	1	8389	1	FBN1	15	48888548	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	109165	48888548	53642844	143	23554										
USP8	9101	broad.mit.edu	37	chr15	50782585	50782585	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cctccaactcataaagccaaGccacagattcctgctgagcg	7	15	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:50782585G>C	uc001zym.3	+	15	2597	c.2097G>C	c.(2095-2097)AAG>AAC	p.K699N	USP8_uc001zyl.3_Missense_Mutation_p.K699N|USP8_uc001zyn.3_Missense_Mutation_p.K699N|USP8_uc010ufh.1_Missense_Mutation_p.K593N|USP8_uc001zyp.3_5'Flank	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	699					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		ATAAAGCCAAGCCACAGATTC	0.498													0	0	0	0.010504	0	17	64										C	50782585	G	C	50782585	3	2	78	1	0	0	0	0	1	0	0	0	17086	962	34	4	2147	4	USP8	15	50782585	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	1894037	50782585	51748807	144	23555										
SNX22	79856	broad.mit.edu	37	chr15	64446167	64446167	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cagcggcctgtcctgagcttCcatgtggatccctatgtttg	11	12	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:64446167C>T	uc002anc.1	+	6	485	c.426C>T	c.(424-426)TTC>TTT	p.F142F	SNX22_uc002amz.1_Silent_p.F114F|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	142					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						TCCTGAGCTTCCATGTGGATC	0.612											OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.011902	0	34	176										T	64446167	C	T	64446167	2	4	78	1	0	0	0	0	0	0	0	1	14894	854	30	1		1	SNX22	15	64446167	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	13663582	64446167	38085225	145	23556										
MTFMT	123263	broad.mit.edu	37	chr15	65316099	65316099	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggggctgggccacgccatctCgggaggcaactgggatgaac	17	11	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:65316099C>T	uc002aof.3	-	3	479	c.453G>A	c.(451-453)CCG>CCA	p.P151P		NM_139242	NP_640335	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	151						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			ovary(2)	2					Tetrahydrofolic acid(DB00116)	CACGCCATCTCGGGAGGCAAC	0.438													0	0	0	0.014758	0	5	13										T	65316099	C	T	65316099	2	4	78	1	0	0	0	0	0	0	0	1	9924	871	31	1		1	MTFMT	15	65316099	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	869932	65316099	37215293	146	23557										
UACA	55075	broad.mit.edu	37	chr15	70979935	70979935	+	Frame_Shift_Del	DEL	T	T	-													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctatctatcagcagttgacaTattgttggcctactcatctg					rs147378902		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:70979935delT	uc002asr.2	-	7	650	c.546delA	c.(544-546)ATAfs	p.I182fs	UACA_uc010uke.1_Intron|UACA_uc002asq.2_Frame_Shift_Del_p.I169fs|UACA_uc010bin.1_Frame_Shift_Del_p.I168fs	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	182	ANK 5.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						GCAGTTGACATATTGTTGGCC	0.428																		21	96	---	---								-	70979935	T	-	70979935	7	5	78	1	0	1	0	1	0	0	0	0	16821	1396	49	0	3756	0	UACA	15	70979935	Frame_Shift_Del	DEL	T	TCGA-FD-A3NA-01A-11D-A21A-08	5663836	70979935	31551457	147	23558										
CCDC33	80125	broad.mit.edu	37	chr15	74554886	74554886	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggggacacggtgaatgtggaGatccaagctgaggatgcagg	18	6	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:74554886G>C	uc002axo.2	+	3	685	c.291G>C	c.(289-291)GAG>GAC	p.E97D		NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	300	C2.						protein binding			ovary(3)|skin(2)	5						TGAATGTGGAGATCCAAGCTG	0.572													0	0	0	0.010729	0	10	12										C	74554886	G	C	74554886	3	2	78	1	0	0	0	0	1	0	0	0	2806	933	33	1	301	1	CCDC33	15	74554886	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	3574951	74554886	27976506	148	23559										
FAH	2184	broad.mit.edu	37	chr15	80465390	80465390	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aagtgggagtatgtccctctCgggccattccttgggaagag	14	9	1	1	rs145851627		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:80465390C>T	uc002bfj.2	+	10	823	c.741C>T	c.(739-741)CTC>CTT	p.L247L	FAH_uc002bfk.1_Silent_p.L247L|FAH_uc002bfm.1_Silent_p.L247L|FAH_uc002bfn.1_Silent_p.L177L	NM_000137	NP_000128	P16930	FAAA_HUMAN	fumarylacetoacetase	247					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding				0						ATGTCCCTCTCGGGCCATTCC	0.572									Tyrosinemia_type_1		OREG0023354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	21	88										T	80465390	C	T	80465390	2	4	78	1	0	0	0	0	0	0	0	1	5371	871	31	1		1	FAH	15	80465390	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	5910504	80465390	22066002	149	23560										
IGF1R	3480	broad.mit.edu	37	chr15	99452048	99452048	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atgtgtttccgaaatttaccGcatggaggaagtgacgggga	14	6	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:99452048G>A	uc002bul.2	+	6	1432	c.1382G>A	c.(1381-1383)CGC>CAC	p.R461H	IGF1R_uc010urq.1_Missense_Mutation_p.R461H|IGF1R_uc010bon.2_Missense_Mutation_p.R461H|IGF1R_uc010urr.1_5'Flank	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	461					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GAAATTTACCGCATGGAGGAA	0.498													0	0	0	0.014758	0	3	25										A	99452048	G	A	99452048	3	1	78	1	0	0	0	0	1	0	0	0	7571	1087	38	2	1404	2	IGF1R	15	99452048	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	18986658	99452048	3079344	150	23561										
SRRM2	23524	broad.mit.edu	37	chr16	2813668	2813668	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aatctagcacaccaccaggcGagagctattttggtgtctca	9	11	2	1	rs150618420	by1000genomes	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:2813668G>A	uc002crk.2	+	11	3688	c.3139G>A	c.(3139-3141)GAG>AAG	p.E1047K	SRRM2_uc002crj.1_Missense_Mutation_p.E951K|SRRM2_uc002crl.1_Missense_Mutation_p.E1047K|SRRM2_uc010bsu.1_Missense_Mutation_p.E951K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1047	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						ACCACCAGGCGAGAGCTATTT	0.468													0	0	0	0.024245	0	12	83										A	2813668	G	A	2813668	3	1	78	1	0	0	0	0	1	0	0	0	15168	1059	37	1	3177	1	SRRM2	16	2813668	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		2813668	87541085	151	23562										
MMP25	64386	broad.mit.edu	37	chr16	3100442	3100442	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	accaggacagctaccccttcGacgggttggggggcacccta	13	14	0	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:3100442G>A	uc002cth.2	+	4	793	c.556G>A	c.(556-558)GAC>AAC	p.D186N	MMP25_uc002cti.1_Missense_Mutation_p.D122N	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	186					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						CTACCCCTTCGACGGGTTGGG	0.622													0	0	0	0.007835	0	34	62										A	3100442	G	A	3100442	3	1	78	1	0	0	0	0	1	0	0	0	9662	1058	37	1	570	1	MMP25	16	3100442	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	286774	3100442	87254311	152	23563										
RBBP6	5930	broad.mit.edu	37	chr16	24583041	24583041	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	acaaagccacttatgatactAaacggccaaatgaagagaca	7	9	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:24583041A>G	uc002dmh.2	+	18	5694	c.4654A>G	c.(4654-4656)AAA>GAA	p.K1552E	RBBP6_uc002dmi.2_Missense_Mutation_p.K1518E|RBBP6_uc010bxr.2_Missense_Mutation_p.K712E|RBBP6_uc002dmk.2_Missense_Mutation_p.K1385E	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1552					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		TTATGATACTAAACGGCCAAA	0.368													0	0	0	0.024245	0	13	33										G	24583041	A	G	24583041	3	3	78	1	0	0	0	0	1	0	0	0	13103	363	13	5	4778	5	RBBP6	16	24583041	Missense_Mutation	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08	21482599	24583041	65771712	153	23564										
HS3ST4	9951	broad.mit.edu	37	chr16	26147147	26147147	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cctttgaggtgctggccttcAaaaaccggaccctcgggctg	12	13	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:26147147A>C	uc002dof.2	+	2	1341	c.949A>C	c.(949-951)AAA>CAA	p.K317Q		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	317	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		GCTGGCCTTCAAAAACCGGAC	0.547													0	0	0	0.01441	0	72	170										C	26147147	A	C	26147147	3	2	78	1	0	0	0	0	1	0	0	0	7367	131	5	5	955	5	HS3ST4	16	26147147	Missense_Mutation	SNP	A	TCGA-FD-A3NA-01A-11D-A21A-08	1564106	26147147	64207606	154	23565										
PHKG2	5261	broad.mit.edu	37	chr16	30764566	30764566	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cccttaggatgcggaagggaGagctgtttgactatctcaca	12	9	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:30764566G>A	uc002dzk.1	+	5	433	c.340G>A	c.(340-342)GAG>AAG	p.E114K	PHKG2_uc002dzi.1_Missense_Mutation_p.E114K|PHKG2_uc002dzj.1_Missense_Mutation_p.E12K	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	114	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			GCGGAAGGGAGAGCTGTTTGA	0.552													0	0	0	0.028581	0	13	39										A	30764566	G	A	30764566	3	1	78	1	0	0	0	0	1	0	0	0	11847	943	33	1	354	1	PHKG2	16	30764566	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	4617419	30764566	59590187	155	23566										
ZNF646	9726	broad.mit.edu	37	chr16	31090265	31090265	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tccagaaccataggcctgggGaggcgacctcagcacagcct	12	14	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:31090265G>A	uc002eap.2	+	2	2909	c.2620G>A	c.(2620-2622)GAG>AAG	p.E874K		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	874					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TAGGCCTGGGGAGGCGACCTC	0.647													0	0	0	0.015359	0	33	87										A	31090265	G	A	31090265	3	1	78	1	0	0	0	0	1	0	0	0	18059	1175	41	1	2622	1	ZNF646	16	31090265	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	325699	31090265	59264488	156	23567										
ZNF646	9726	broad.mit.edu	37	chr16	31090309	31090309	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctctgctgcctctgtggcatGatcttccctgggcgggctgg	14	13	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:31090309G>C	uc002eap.2	+	2	2953	c.2664G>C	c.(2662-2664)ATG>ATC	p.M888I		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	888	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TCTGTGGCATGATCTTCCCTG	0.637													0	0	0	0.00499	0	16	59										C	31090309	G	C	31090309	3	2	78	1	0	0	0	0	1	0	0	0	18059	1290	45	1	2666	1	ZNF646	16	31090309	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	44	31090309	59264444	157	23568										
NOB1	28987	broad.mit.edu	37	chr16	69776286	69776286	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcgttgggatttaagcgtctCcgcccagctcccaaggtgct	12	13	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:69776286C>T	uc002exs.2	-	9	1204	c.1188G>A	c.(1186-1188)CGG>CGA	p.R396R		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	nin one binding protein	396						nucleus	metal ion binding|protein binding				0						TTAAGCGTCTCCGCCCAGCTC	0.587													0	0	0	0.020292	0	11	37										T	69776286	C	T	69776286	2	4	78	1	0	0	0	0	0	0	0	1	10511	842	30	1		1	NOB1	16	69776286	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	38685977	69776286	20578467	158	23569										
PDPR	55066	broad.mit.edu	37	chr16	70190728	70190728	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	taccctgtcgcctccctcttCacccagaagcgccgaaagga	8	17	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:70190728C>T	uc002eyf.1	+	19	3543	c.2586C>T	c.(2584-2586)TTC>TTT	p.F862F	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Silent_p.F762F|PDPR_uc002eyg.1_Silent_p.F529F|PDPR_uc002eyh.2_Silent_p.F207F|PDPR_uc010vls.1_Silent_p.F207F	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	862					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		CCTCCCTCTTCACCCAGAAGC	0.562													0	0	0	0.021553	0	4	30										T	70190728	C	T	70190728	2	4	78	1	0	0	0	0	0	0	0	1	11689	825	29	1		1	PDPR	16	70190728	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	414442	70190728	20164025	159	23570										
TP53	7157	broad.mit.edu	37	chr17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttccactcggataagatgctGaggaggggccagacctaaga	13	9	0	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006122	0	15	32										A	7578275	G	A	7578275	4	1	78	1	0	0	0	0	0	1	0	0	16378	1299	45	1	720	1	TP53	17	7578275	Nonsense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		7578275	73616935	160	23571										
TRPV2	51393	broad.mit.edu	37	chr17	16326850	16326850	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtaagctacctcctggagaaCccacaccagcccgccagcct	8	18	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:16326850C>A	uc002gpy.2	+	5	1060	c.693C>A	c.(691-693)AAC>AAA	p.N231K	TRPV2_uc002gpz.2_Intron	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	231	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 4.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TCCTGGAGAACCCACACCAGC	0.607													1	0	7.53189e-24	0.007835	8.28168e-24	37	56										A	16326850	C	A	16326850	3	1	78	1	0	0	0	0	1	0	0	0	16593	506	18	4	707	4	TRPV2	17	16326850	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	8748575	16326850	64868360	161	23572										
NF1	4763	broad.mit.edu	37	chr17	29701127	29701127	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aagccaagtgcagaagcaaaGaagcgctggcagtttcaaac	11	9	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:29701127G>C	uc002hgg.2	+	58	8807	c.8474G>C	c.(8473-8475)AGA>ACA	p.R2825T	NF1_uc002hgh.2_Missense_Mutation_p.R2804T|NF1_uc010cso.2_Missense_Mutation_p.R1031T|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2825					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAGAAGCAAAGAAGCGCTGGC	0.468			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.010729	0	9	49										C	29701127	G	C	29701127	3	2	78	1	0	0	0	0	1	0	0	0	10356	942	33	1	8765	1	NF1	17	29701127	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	13374277	29701127	51494083	162	23573										
LIG3	3980	broad.mit.edu	37	chr17	33318055	33318055	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	attaagactgtttacaacttGaacgataagcagattgtgaa	8	5	0	4			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:33318055G>C	uc002hik.1	+	5	1071	c.963G>C	c.(961-963)TTG>TTC	p.L321F	LIG3_uc002hij.2_Missense_Mutation_p.L321F|LIG3_uc010cth.1_Missense_Mutation_p.L330F	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	321					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	TTTACAACTTGAACGATAAGC	0.488								Other_BER_factors					0	0	0	0.027894	0	35	66										C	33318055	G	C	33318055	3	2	78	1	0	0	0	0	1	0	0	0	8782	1281	45	1	977	1	LIG3	17	33318055	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	3616928	33318055	47877155	163	23574										
SLFN5	162394	broad.mit.edu	37	chr17	33586688	33586688	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgagacaattgcccacaagaGaatggactgcttggatgatg	12	7	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:33586688G>C	uc002hjf.3	+	2	1096	c.979G>C	c.(979-981)GAA>CAA	p.E327Q	SLFN5_uc002hje.2_Missense_Mutation_p.E327Q|SLFN5_uc010wcg.1_Missense_Mutation_p.E327Q	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	327					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GCCCACAAGAGAATGGACTGC	0.517													0	0	0	0.009535	0	29	107										C	33586688	G	C	33586688	3	2	78	1	0	0	0	0	1	0	0	0	14737	943	33	1	981	1	SLFN5	17	33586688	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	268633	33586688	47608522	164	23575										
HSD17B1	3292	broad.mit.edu	37	chr17	40705230	40705230	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cctccgggatccctggagacGttgcagctggacgtaaggga	15	11	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:40705230G>A	uc002hzw.2	+	2	1154	c.186G>A	c.(184-186)ACG>ACA	p.T62T	HSD17B1_uc002hzx.2_Silent_p.T62T|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_Silent_p.N117N|HSD17B1_uc010cyi.2_Silent_p.T93T	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	62					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	CCCTGGAGACGTTGCAGCTGG	0.647													0	0	0	0.01441	0	37	77										A	40705230	G	A	40705230	2	1	78	1	0	0	0	0	0	0	0	1	7378	1132	40	2		2	HSD17B1	17	40705230	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	7118542	40705230	40489980	165	23576										
HEXIM1	10614	broad.mit.edu	37	chr17	43226833	43226833	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agagagggcgagaagggccaGaatggggacgactcgtccgc	18	9	0	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:43226833G>C	uc002iig.2	+	1	2150	c.276G>C	c.(274-276)CAG>CAC	p.Q92H		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	92					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						AGAAGGGCCAGAATGGGGACG	0.682											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	29										C	43226833	G	C	43226833	3	2	78	1	0	0	0	0	1	0	0	0	7076	933	33	1	278	1	HEXIM1	17	43226833	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2521603	43226833	37968377	166	23577										
HEXIM1	10614	broad.mit.edu	37	chr17	43227260	43227260	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gggccgccgccaaatccgacGacaccagcgatgacgacttc	11	16	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:43227260G>T	uc002iig.2	+	1	2577	c.703G>T	c.(703-705)GAC>TAC	p.D235Y		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	235	Autoinhibitory acidic region; in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						CAAATCCGACGACACCAGCGA	0.612													1	0	1.37522e-17	0.007413	1.48524e-17	14	73										T	43227260	G	T	43227260	3	4	78	1	0	0	0	0	1	0	0	0	7076	1058	37	3	705	3	HEXIM1	17	43227260	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	427	43227260	37967950	167	23578										
LRRC37A2	474170	broad.mit.edu	37	chr17	44626216	44626216	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtctacaccaagccttccttCacccaagagcataaggcagc	7	15	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:44626216C>T	uc002ikn.1	+	9	3714	c.3711C>T	c.(3709-3711)TTC>TTT	p.F1237F	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Silent_p.F198F|LRRC37A2_uc010dax.1_Silent_p.F167F	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1237	Extracellular (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AGCCTTCCTTCACCCAAGAGC	0.592													0	0	0	0.007413	0	15	129										T	44626216	C	T	44626216	2	4	78	1	0	0	0	0	0	0	0	1	8992	825	29	1		1	LRRC37A2	17	44626216	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	1398956	44626216	36568994	168	23579										
DLX4	1748	broad.mit.edu	37	chr17	48047109	48047109	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cagagcaccctcaggaactcGaggcaggtaagttcggccgt	13	12	1	1	rs145736583		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:48047109G>A	uc002ipv.2	+	1	548	c.277G>A	c.(277-279)GAG>AAG	p.E93K		NM_138281	NP_612138	Q92988	DLX4_HUMAN	distal-less homeobox 4 isoform a	93				MTSLPCPLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAA SPNLSYSRPYGHLLSYPYTEPANPGDSYLSCQQPAALSQPL CGPAEHPQELEA -> GGSLSLPPEPLCARCPTKEGAAPRR PGFWGSLETQAATVWRGRHGHFSCRVRLSRGAARYSRRGQG KPGVTISAARLVFKVLSAGPLTHPAGRSRRLPRGHRLKPLS IALSLCLQCPSSVISRPRLSPGPSLSAPPYPKLAPPPVAEL RPPTAGAAVPWLWPSARFLPRVTGPIRVGAPLGAELRLVSP GAVNVGVETLHAE (in Ref. 9).	multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCAGGAACTCGAGGCAGGTAA	0.667													0	0	0	0.020292	0	14	108										A	48047109	G	A	48047109	3	1	78	1	0	0	0	0	1	0	0	0	4573	1059	37	1	279	1	DLX4	17	48047109	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	3420893	48047109	33148101	169	23580										
TOB1	10140	broad.mit.edu	37	chr17	48941096	48941096	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtaagaaacctcaaatgggtCgatccaaacactaagatcct	7	10	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:48941096C>T	uc002isw.2	-	1	318	c.283G>A	c.(283-285)GAC>AAC	p.D95N	TOB1_uc010wmy.1_Missense_Mutation_p.D95N|TOB1_uc010wmz.1_Missense_Mutation_p.D95N	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	95					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TCAAATGGGTCGATCCAAACA	0.428											OREG0024576	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	7	73										T	48941096	C	T	48941096	3	4	78	1	0	0	0	0	1	0	0	0	16344	884	31	1	758	1	TOB1	17	48941096	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	893987	48941096	32254114	170	23581										
AKAP1	8165	broad.mit.edu	37	chr17	55183156	55183156	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gatcagagtcctcgggcattCttcctaacaccacagacatg	8	13	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:55183156C>T	uc002iux.2	+	2	562	c.331C>T	c.(331-333)CTT>TTT	p.L111F	AKAP1_uc010wnl.1_Missense_Mutation_p.L111F|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Missense_Mutation_p.L111F	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	111					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CTCGGGCATTCTTCCTAACAC	0.547													0	0	0	0.015359	0	34	55										T	55183156	C	T	55183156	3	4	78	1	0	0	0	0	1	0	0	0	445	913	32	1	333	1	AKAP1	17	55183156	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	6242060	55183156	26012054	171	23582										
VEZF1	7716	broad.mit.edu	37	chr17	56056663	56056663	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cttttggttactggtctcttCactcatgcatgctattacaa	6	10	3	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:56056663C>T	uc002ivf.1	-	5	1131	c.988G>A	c.(988-990)GAA>AAA	p.E330K	VEZF1_uc010dcn.1_Missense_Mutation_p.E180K	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	330					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CTGGTCTCTTCACTCATGCAT	0.284													0	0	0	0.027356	0	25	49										T	56056663	C	T	56056663	3	4	78	1	0	0	0	0	1	0	0	0	17152	835	29	1	585	1	VEZF1	17	56056663	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	873507	56056663	25138547	172	23583										
NUP85	79902	broad.mit.edu	37	chr17	73231253	73231253	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtgtctggaggacttgacgtCaagaagacctgtgcatggag	15	7	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:73231253C>G	uc002jng.1	+	18	2086	c.1826C>G	c.(1825-1827)TCA>TGA	p.S609*	NUP85_uc010dgd.1_Nonsense_Mutation_p.S564*|NUP85_uc010wrv.1_Nonsense_Mutation_p.S563*|NUP85_uc002jnh.1_Nonsense_Mutation_p.S212*	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	609					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GACTTGACGTCAAGAAGACCT	0.522													0	0	0	0.020292	0	8	75										G	73231253	C	G	73231253	4	3	78	1	0	0	0	0	0	1	0	0	10770	838	29	1	1896	1	NUP85	17	73231253	Nonsense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	17174590	73231253	7963957	173	23584										
GGA3	23163	broad.mit.edu	37	chr17	73239175	73239175	+	Frame_Shift_Del	DEL	T	T	-													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cctcatcatcaaaaacagggTttttgggacgaggtggtgga							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:73239175delT	uc002jni.1	-	6	506	c.497delA	c.(496-498)AACfs	p.N166fs	GGA3_uc002jnj.1_Frame_Shift_Del_p.N133fs|GGA3_uc010wrw.1_Frame_Shift_Del_p.N44fs|GGA3_uc002jnk.1_Frame_Shift_Del_p.N94fs|GGA3_uc010wrx.1_Frame_Shift_Del_p.N44fs|GGA3_uc010wry.1_Frame_Shift_Del_p.N94fs|GGA3_uc010wrz.1_Intron	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	166	Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			AAAAACAGGGTTTTTGGGACG	0.542																		7	303	---	---								-	73239175	T	-	73239175	7	5	78	1	0	1	0	1	0	0	0	0	6354	1725	60	0	1810	0	GGA3	17	73239175	Frame_Shift_Del	DEL	T	TCGA-FD-A3NA-01A-11D-A21A-08	7922	73239175	7956035	174	23585										
ITGB4	3691	broad.mit.edu	37	chr17	73738710	73738710	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agggcgtggagctggtggacGtacgggtgcccctctttatc	16	10	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:73738710G>A	uc002jpg.2	+	25	3017	c.2830G>A	c.(2830-2832)GTA>ATA	p.V944I	ITGB4_uc002jph.2_Missense_Mutation_p.V944I|ITGB4_uc002jpi.3_Missense_Mutation_p.V944I|ITGB4_uc010dgp.1_Missense_Mutation_p.R956H|ITGB4_uc002jpj.2_Missense_Mutation_p.V944I	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	944	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGGTGGACGTACGGGTGCC	0.692													0	0	0	0.021553	0	4	120										A	73738710	G	A	73738710	3	1	78	1	0	0	0	0	1	0	0	0	7897	1145	40	2	2924	2	ITGB4	17	73738710	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	499535	73738710	7456500	175	23586										
DNAH17	8632	broad.mit.edu	37	chr17	76547693	76547693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcaagttgtgcagaatttctCgcacctcttgaatgtactga	9	9	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:76547693C>T	uc002jvv.1	-	12	1527	c.1421G>A	c.(1420-1422)CGA>CAA	p.R474Q						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGAATTTCTCGCACCTCTTG	0.338													0	0	0	0.006214	0	7	76										T	76547693	C	T	76547693	3	4	78	1	0	0	0	0	1	0	0	0	4601	884	31	1	11337	1	DNAH17	17	76547693	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	2808983	76547693	4647517	176	23587										
SLC38A10	124565	broad.mit.edu	37	chr17	79256117	79256117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggcgaacagcaggaacatgcGgaaggtgccgcccacctgcg	15	13	0	0	rs141053452	byFrequency	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:79256117G>A	uc002jzz.1	-	5	748	c.373C>T	c.(373-375)CGC>TGC	p.R125C	SLC38A10_uc002jzy.1_Missense_Mutation_p.R43C|SLC38A10_uc002kab.2_Missense_Mutation_p.R125C	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	125	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AGGAACATGCGGAAGGTGCCG	0.682													0	0	0	0.006214	0	9	16										A	79256117	G	A	79256117	3	1	78	1	0	0	0	0	1	0	0	0	14602	1116	39	2	3312	2	SLC38A10	17	79256117	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2708424	79256117	1939093	177	23588										
PHLPP1	23239	broad.mit.edu	37	chr18	60642723	60642723	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ccaggaggatccttcaccttGacctctgctaatgtgggcaa	10	12	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr18:60642723G>C	uc002lis.2	+	17	2491	c.2313G>C	c.(2311-2313)TTG>TTC	p.L771F		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1283	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CCTTCACCTTGACCTCTGCTA	0.507													0	0	0	0.009535	0	27	91										C	60642723	G	C	60642723	3	2	78	1	0	0	0	0	1	0	0	0	11854	1281	45	1	3911	1	PHLPP1	18	60642723	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		60642723	17434525	178	23589										
HCN2	610	broad.mit.edu	37	chr19	616296	616296	+	Frame_Shift_Del	DEL	C	C	-													0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gccctcgctgcctcacggcgCccccggccccgcggcctcca							TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:616296delC	uc002lpe.2	+	8	2545	c.2492delC	c.(2491-2493)GCCfs	p.A831fs		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	831	Pro-rich.|Cytoplasmic (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCAcggcgcccccggcccc	0.413																		2	4	---	---								-	616296	C	-	616296	7	5	78	1	0	1	0	1	0	0	0	0	6997	739	26	0	2522	0	HCN2	19	616296	Frame_Shift_Del	DEL	C	TCGA-FD-A3NA-01A-11D-A21A-08		616296	58512687	179	23590										
KDM4B	23030	broad.mit.edu	37	chr19	5135468	5135468	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ccctgagatgtgcttcacctCtggcggtgagaacacggagc	13	12	2	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:5135468C>G	uc002mbq.3	+	15	2430	c.2204C>G	c.(2203-2205)TCT>TGT	p.S735C	KDM4B_uc010xim.1_Missense_Mutation_p.S769C|KDM4B_uc002mbr.3_Missense_Mutation_p.S493C	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	735	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						TGCTTCACCTCTGGCGGTGAG	0.642													0	0	0	0.016723	0	13	37										G	5135468	C	G	5135468	3	3	78	1	0	0	0	0	1	0	0	0	8129	913	32	1	2254	1	KDM4B	19	5135468	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	4519172	5135468	53993515	180	23591										
PTPRS	5802	broad.mit.edu	37	chr19	5244216	5244216	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gcgctggccggggcctgctcGcctgtgcgggtgaccacgga	18	14	0	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:5244216G>A	uc002mbv.2	-	11	1500	c.1266C>T	c.(1264-1266)GGC>GGT	p.G422G	PTPRS_uc002mbu.1_Silent_p.G409G|PTPRS_uc010xin.1_Silent_p.G409G|PTPRS_uc002mbw.2_Silent_p.G409G|PTPRS_uc002mbx.2_Silent_p.G413G|PTPRS_uc002mby.2_Silent_p.G409G	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	422	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGGCCTGCTCGCCTGTGCGGG	0.711													0	0	0	0.014323	0	21	86										A	5244216	G	A	5244216	2	1	78	1	0	0	0	0	0	0	0	1	12811	1074	38	2		2	PTPRS	19	5244216	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	108748	5244216	53884767	181	23592										
MUC16	94025	broad.mit.edu	37	chr19	9077046	9077046	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ggcttgtaatgccttggtctCcagagggcagagacactagt	13	9	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:9077046C>G	uc002mkp.2	-	3	10604	c.10400G>C	c.(10399-10401)GGA>GCA	p.G3467A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3468	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCTTGGTCTCCAGAGGGCAG	0.507													0	0	0	0.001984	0	5	24										G	9077046	C	G	9077046	3	3	78	1	0	0	0	0	1	0	0	0	9973	855	30	1	33451	1	MUC16	19	9077046	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	3832830	9077046	50051937	182	23593										
NCAN	1463	broad.mit.edu	37	chr19	19339025	19339025	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tgagccctcaggtggccctgGatacaagcattgtgacgccc	12	13	1	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:19339025G>A	uc002nlz.2	+	8	2695	c.2596G>A	c.(2596-2598)GAT>AAT	p.D866N	NCAN_uc010ecc.1_Missense_Mutation_p.D430N	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	866					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGTGGCCCTGGATACAAGCAT	0.597													0	0	0	0.007291	0	22	96										A	19339025	G	A	19339025	3	1	78	1	0	0	0	0	1	0	0	0	10204	1174	41	1	2622	1	NCAN	19	19339025	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	10261979	19339025	39789958	183	23594										
ZNF257	113835	broad.mit.edu	37	chr19	22271465	22271465	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	cagctcttactacccttactCaacataagagaattcatact	3	12	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:22271465C>T	uc010ecx.2	+	4	1082	c.913C>T	c.(913-915)CAA>TAA	p.Q305*	ZNF257_uc010ecy.2_Nonsense_Mutation_p.Q273*	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	305	C2H2-type 5; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TACCCTTACTCAACATAAGAG	0.393													0	0	0	0.006214	0	9	29										T	22271465	C	T	22271465	4	4	78	1	0	0	0	0	0	1	0	0	17797	827	29	1	927	1	ZNF257	19	22271465	Nonsense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	2932440	22271465	36857518	184	23595										
PSG3	5671	broad.mit.edu	37	chr19	43236936	43236936	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gaggaacaggagatactcacGgaggagattcagggtgactg	16	6	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:43236936G>A	uc002oue.2	-	3	841	c.709C>T	c.(709-711)CCG>TCG	p.P237S	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Missense_Mutation_p.P259S	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	237					defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				AGATACTCACGGAGGAGATTC	0.542													0	0	0	0.01441	0	141	277										A	43236936	G	A	43236936	3	1	78	1	0	0	0	0	1	0	0	0	12656	1130	39	2	593	2	PSG3	19	43236936	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	20965471	43236936	15892047	185	23596										
CCDC61	729440	broad.mit.edu	37	chr19	46509948	46509948	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aactccaagcgctacctgatCctcatctactccgtggagtt	7	14	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:46509948C>G	uc002pdw.2	+	5	534	c.534C>G	c.(532-534)ATC>ATG	p.I178M		NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		GCTACCTGATCCTCATCTACT	0.652													0	0	0	0.01441	0	58	110										G	46509948	C	G	46509948	3	3	78	1	0	0	0	0	1	0	0	0	2832	845	30	1	552	1	CCDC61	19	46509948	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	3273012	46509948	12619035	186	23597										
GRIN2D	2906	broad.mit.edu	37	chr19	48945175	48945175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	caagggctcccgctggaagcGgcccatcgacctggcgttgc	14	15	0	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:48945175G>A	uc002pjc.3	+	11	2490	c.2402G>A	c.(2401-2403)CGG>CAG	p.R801Q	GRIN2D_uc010elx.2_Missense_Mutation_p.R36Q	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	801	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CGCTGGAAGCGGCCCATCGAC	0.627													0	0	0	0.009096	0	3	37										A	48945175	G	A	48945175	3	1	78	1	0	0	0	0	1	0	0	0	6782	1116	39	2	2440	2	GRIN2D	19	48945175	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2435227	48945175	10183808	187	23598										
C20orf96	140680	broad.mit.edu	37	chr20	259903	259903	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtctcgatcagctcccggttGagcttgctgaggaagttctc	12	11	3	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:259903G>A	uc002wde.1	-	5	514	c.375C>T	c.(373-375)CTC>CTT	p.L125L	C20orf96_uc002wdc.2_Silent_p.L72L|C20orf96_uc002wdd.2_Silent_p.L90L|C20orf96_uc010zpi.1_Silent_p.L72L|C20orf96_uc010zpj.1_Silent_p.L90L|C20orf96_uc010zpk.1_Silent_p.L63L	NM_153269	NP_695001	Q9NUD7	CT096_HUMAN	hypothetical protein LOC140680	125	Potential.										0		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GCTCCCGGTTGAGCTTGCTGA	0.672													0	0	0	0.027356	0	23	187										A	259903	G	A	259903	2	1	78	1	0	0	0	0	0	0	0	1	2122	1277	45	1		1	C20orf96	20	259903	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		259903	62765617	188	23599										
SLC32A1	140679	broad.mit.edu	37	chr20	37357147	37357147	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctctttcacctgcgcctgctCtggcgcaagctgctgtggca	11	15	3	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:37357147C>T	uc002xjc.2	+	2	1706	c.1443C>T	c.(1441-1443)CTC>CTT	p.L481L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	481	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGCGCCTGCTCTGGCGCAAGC	0.647													0	0	0	0.021553	0	5	70										T	37357147	C	T	37357147	2	4	78	1	0	0	0	0	0	0	0	1	14565	900	32	1		1	SLC32A1	20	37357147	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	37097244	37357147	25668373	189	23600										
CDH26	60437	broad.mit.edu	37	chr20	58545159	58545159	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aaagatctaccagcctctacGgcgatccaagagaagatggg	11	10	2	3			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:58545159G>A	uc002ybe.2	+	3	449	c.149G>A	c.(148-150)CGG>CAG	p.R50Q	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	50	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CAGCCTCTACGGCGATCCAAG	0.498													0	0	0	0.01441	0	42	98										A	58545159	G	A	58545159	3	1	78	1	0	0	0	0	1	0	0	0	3110	1116	39	2	159	2	CDH26	20	58545159	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	21188012	58545159	4480361	190	23601										
SFRS15	57466	broad.mit.edu	37	chr21	33043774	33043774	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttcaacggatgaggtagcctCagcaggtaactcttcagaag	11	9	4	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr21:33043774C>T	uc002ypd.2	-	20	3808	c.3382G>A	c.(3382-3384)GAG>AAG	p.E1128K	SFRS15_uc002ype.2_Missense_Mutation_p.E1106K|SFRS15_uc010glu.2_Missense_Mutation_p.E1113K	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	1128						nucleus	nucleotide binding|RNA binding				0						GAGGTAGCCTCAGCAGGTAAC	0.498													0	0	0	0.028581	0	12	36										T	33043774	C	T	33043774	3	4	78	1	0	0	0	0	1	0	0	0	14171	835	29	1	65	1	SFRS15	21	33043774	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08		33043774	15086121	191	23602										
DSCAM	1826	broad.mit.edu	37	chr21	41450881	41450881	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gttgatgctggcaaacagctCctgctcctttgagaactggg	12	10	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr21:41450881C>T	uc002yyq.1	-	26	4896	c.4444G>A	c.(4444-4446)GAG>AAG	p.E1482K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1482	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCAAACAGCTCCTGCTCCTTT	0.582													0	0	0	0.007291	0	19	47										T	41450881	C	T	41450881	3	4	78	1	0	0	0	0	1	0	0	0	4768	864	30	1	1626	1	DSCAM	21	41450881	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	8407107	41450881	6679014	192	23603										
NIPSNAP1	8508	broad.mit.edu	37	chr22	29957498	29957498	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ctgtcggagggaggcaccttGagcttgtatgtcctcagctc	13	11	1	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:29957498G>C	uc003afx.3	-	6	649	c.576C>G	c.(574-576)CTC>CTG	p.L192L	NIPSNAP1_uc011akp.1_Silent_p.L172L	NM_003634	NP_003625	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1	192								p.?(1)		skin(1)	1						GAGGCACCTTGAGCTTGTATG	0.577													0	0	0	0.01441	0	44	83										C	29957498	G	C	29957498	2	2	78	1	0	0	0	0	0	0	0	1	10429	1277	45	1		1	NIPSNAP1	22	29957498	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		29957498	21347068	193	23604										
GATSL3	652968	broad.mit.edu	37	chr22	30682066	30682066	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agctcccccgaggagctggtCagcaggaggtcactggggaa	16	11	2	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:30682066C>T	uc003ahd.2	-	7	895	c.765G>A	c.(763-765)CTG>CTA	p.L255L	GATSL3_uc003ahc.2_Silent_p.L217L|GATSL3_uc003ahe.2_Silent_p.L218L|GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Silent_p.L390L	NM_001037666	NP_001032755	Q8WTX7	GATL3_HUMAN	GATS protein-like 3	255										breast(1)	1						AGGAGCTGGTCAGCAGGAGGT	0.672													0	0	0	0.021553	0	4	21										T	30682066	C	T	30682066	2	4	78	1	0	0	0	0	0	0	0	1	6265	813	29	1		1	GATSL3	22	30682066	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	724568	30682066	20622500	194	23605										
DEPDC5	9681	broad.mit.edu	37	chr22	32242914	32242914	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agtggggaagaagggaacctCagctctctctgccctgttgg	14	10	3	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:32242914C>T	uc003als.2	+	31	3231	c.3089C>T	c.(3088-3090)TCA>TTA	p.S1030L	DEPDC5_uc011als.1_Missense_Mutation_p.S961L|DEPDC5_uc011alu.1_Missense_Mutation_p.S1039L|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.S1030L|DEPDC5_uc003alu.2_Missense_Mutation_p.S479L|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.S360L|DEPDC5_uc003alw.2_Missense_Mutation_p.S328L|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_Missense_Mutation_p.S34L	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1030					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AAGGGAACCTCAGCTCTCTCT	0.552													0	0	0	0.028581	0	14	68										T	32242914	C	T	32242914	3	4	78	1	0	0	0	0	1	0	0	0	4442	838	29	1	3225	1	DEPDC5	22	32242914	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	1560848	32242914	19061652	195	23606										
ANKRD54	129138	broad.mit.edu	37	chr22	38234561	38234561	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	tagagctgtgcggcccttgtCatcagctgcacagggatccg	13	12	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:38234561C>T	uc003auc.2	-	3	479	c.421G>A	c.(421-423)GAC>AAC	p.D141N	ANKRD54_uc003aud.2_Missense_Mutation_p.D18N	NM_138797	NP_620152	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	141											0	Melanoma(58;0.045)					CGGCCCTTGTCATCAGCTGCA	0.577													0	0	0	0.010729	0	9	23										T	38234561	C	T	38234561	3	4	78	1	0	0	0	0	1	0	0	0	680	826	29	1	505	1	ANKRD54	22	38234561	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	5991647	38234561	13070005	196	23607										
PIM3	415116	broad.mit.edu	37	chr22	50356727	50356727	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gacctgcggctgtgcaccctCgaccctgatgacgtggccag	13	15	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:50356727C>G	uc003bjb.2	+	6	1386	c.933C>G	c.(931-933)CTC>CTG	p.L311L	PIM3_uc011arj.1_Silent_p.L74L	NM_001001852	NP_001001852	Q86V86	PIM3_HUMAN	serine/threonine protein kinase pim-3	311					cell cycle|negative regulation of apoptosis|regulation of mitotic cell cycle		ATP binding|protein binding|protein serine/threonine kinase activity				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.196)|LUAD - Lung adenocarcinoma(64;0.247)		TGTGCACCCTCGACCCTGATG	0.677													0	0	0	0.00308	0	7	22										G	50356727	C	G	50356727	2	3	78	1	0	0	0	0	0	0	0	1	11929	871	31	1		1	PIM3	22	50356727	Silent	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	12122166	50356727	947839	197	23608										
PLXNB2	23654	broad.mit.edu	37	chr22	50714172	50714172	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	ttctccagtgcagcggcaatCtgctgcaggcggaaggccag	14	12	2	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:50714172C>G	uc003bkv.3	-	37	5584	c.5478G>C	c.(5476-5478)CAG>CAC	p.Q1826H	PLXNB2_uc003bkt.1_Missense_Mutation_p.Q618H|PLXNB2_uc003bku.1_Missense_Mutation_p.Q811H	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1826	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCGGCAATCTGCTGCAGGC	0.597											OREG0026679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	10	55										G	50714172	C	G	50714172	3	3	78	1	0	0	0	0	1	0	0	0	12124	912	32	1	42	1	PLXNB2	22	50714172	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	357445	50714172	590394	198	23609										
RBM10	8241	broad.mit.edu	37	chrX	47045491	47045491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	agtaccgggaccgtgcagctGaacgcagagaaaagtatggc	14	9	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:47045491G>A	uc004dhf.2	+	22	2837	c.2458G>A	c.(2458-2460)GAA>AAA	p.E820K	RBM10_uc004dhg.2_Missense_Mutation_p.E742K|RBM10_uc004dhh.2_Missense_Mutation_p.E819K|RBM10_uc010nhq.2_Missense_Mutation_p.E743K|RBM10_uc004dhi.2_Missense_Mutation_p.E885K	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	820					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CCGTGCAGCTGAACGCAGAGA	0.552													0	0	0	0.007413	0	16	17										A	47045491	G	A	47045491	3	1	78	1	0	0	0	0	1	0	0	0	13111	1291	45	1	2540	1	RBM10	23	47045491	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08		47045491	108225069	199	23610										
CACNA1F	778	broad.mit.edu	37	chrX	49071570	49071570	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	atggctagggcaactgtgttGagcaggatgagcaggaacat	15	6	0	2			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:49071570G>C	uc004dnb.2	-	29	3668	c.3606C>G	c.(3604-3606)CTC>CTG	p.L1202L	CACNA1F_uc010nip.2_Silent_p.L1191L	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1202	Helical; Name=S1 of repeat IV; (Potential).|IV.				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CAACTGTGTTGAGCAGGATGA	0.552													0	0	0	0.027894	0	29	29										C	49071570	G	C	49071570	2	2	78	1	0	0	0	0	0	0	0	1	2543	1277	45	1		1	CACNA1F	23	49071570	Silent	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	2026079	49071570	106198990	200	23611										
STAG2	10735	broad.mit.edu	37	chrX	123185061	123185061	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	aactggaactttttaccagtCggttcaaggttagtattact	8	7	1	0			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:123185061C>T	uc004etz.3	+	11	1447	c.1108C>T	c.(1108-1110)CGG>TGG	p.R370W	STAG2_uc004eua.2_Missense_Mutation_p.R370W|STAG2_uc004eub.2_Missense_Mutation_p.R370W|STAG2_uc004euc.2_Missense_Mutation_p.R370W|STAG2_uc004eud.2_Missense_Mutation_p.R370W|STAG2_uc004eue.2_Missense_Mutation_p.R370W	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	370	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TTTTACCAGTCGGTTCAAGGT	0.294													0	0	0	0.014758	0	4	5										T	123185061	C	T	123185061	3	4	78	1	0	0	0	0	1	0	0	0	15242	875	31	1	1146	1	STAG2	23	123185061	Missense_Mutation	SNP	C	TCGA-FD-A3NA-01A-11D-A21A-08	74113491	123185061	32085499	201	23612										
TAZ	6901	broad.mit.edu	37	chrX	153640483	153640483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507537688442211	101	3.64905476401508e-36	3.79033838704099	4.62775119617225	3.17972488038277	0.781504739742392	0.870583303982605	74	gtacgagctcatcgagaagcGaggcccggccacgcccctca	12	16	2	1			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:153640483G>A	uc004fkx.2	+	2	474	c.170G>A	c.(169-171)CGA>CAA	p.R57Q	DNASE1L1_uc004fks.1_5'Flank|DNASE1L1_uc004fkt.1_5'Flank|DNASE1L1_uc004fku.1_5'Flank|DNASE1L1_uc004fkv.1_5'Flank|DNASE1L1_uc004fkw.1_5'Flank|TAZ_uc004fky.2_Missense_Mutation_p.R57Q|TAZ_uc004fkz.2_RNA|TAZ_uc004fla.2_Missense_Mutation_p.R57Q|TAZ_uc004flb.2_Missense_Mutation_p.R57Q|TAZ_uc010nuy.2_Missense_Mutation_p.R75Q|TAZ_uc004flc.3_Intron	NM_000116	NP_000107	Q16635	TAZ_HUMAN	tafazzin isoform 1	57					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCGAGAAGCGAGGCCCGGCC	0.662											OREG0003602	type=REGULATORY REGION|Gene=DNASE1L1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.028581	0	14	6										A	153640483	G	A	153640483	3	1	78	1	0	0	0	0	1	0	0	0	15593	1058	37	1	176	1	TAZ	23	153640483	Missense_Mutation	SNP	G	TCGA-FD-A3NA-01A-11D-A21A-08	30455422	153640483	1630077	202	23613										
PRDM16	63976	broad.mit.edu	37	chr1	3160668	3160668	+	Frame_Shift_Del	DEL	G	G	-													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cagcaaatactgacggacgtGgaagtgtcgccccaggaagg							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:3160668delG	uc001akf.2	+	3	485	c.405delG	c.(403-405)GTGfs	p.V135fs	PRDM16_uc001akc.2_Frame_Shift_Del_p.V135fs|PRDM16_uc001akd.2_Frame_Shift_Del_p.V135fs|PRDM16_uc001ake.2_Frame_Shift_Del_p.V135fs|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	135	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGACGGACGTGGAAGTGTCGC	0.557			T	EVI1	MDS|AML													23	67	---	---								-	3160668	G	-	3160668	7	5	79	1	0	1	0	1	0	0	0	0	12457	1335	47	0	415	0	PRDM16	1	3160668	Frame_Shift_Del	DEL	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		3160668	246089953	1	23614										
KCNAB2	8514	broad.mit.edu	37	chr1	6156774	6156774	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agctgaaggagctgcaggccAtcgccgagcgcctgggctgc	16	13	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:6156774A>G	uc009vlv.1	+	14	1018	c.883A>G	c.(883-885)ATC>GTC	p.I295V	KCNAB2_uc001alv.1_Missense_Mutation_p.I295V|KCNAB2_uc001alw.1_Missense_Mutation_p.I281V|KCNAB2_uc001alx.1_Missense_Mutation_p.I295V|KCNAB2_uc001aly.1_Missense_Mutation_p.I343V|KCNAB2_uc009vlw.1_Missense_Mutation_p.I228V|KCNAB2_uc001alu.2_Missense_Mutation_p.I295V	NM_003636	NP_003627	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related	295						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGCAGGCCATCGCCGAGCG	0.692													0	0	0	0.014758	0	5	7										G	6156774	A	G	6156774	3	3	79	1	0	0	0	0	1	0	0	0	8010	217	8	5	933	5	KCNAB2	1	6156774	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	2996106	6156774	243093847	2	23615										
PLEKHG5	57449	broad.mit.edu	37	chr1	6529488	6529488	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acagcactgtgaaactcattCaggtagataaggaggaagga	12	6	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:6529488C>T	uc001ano.1	-	19	2225	c.2124G>A	c.(2122-2124)CTG>CTA	p.L708L	PLEKHG5_uc001ann.1_Silent_p.L689L|PLEKHG5_uc001anq.1_Silent_p.L729L|PLEKHG5_uc001anp.1_Silent_p.L729L|PLEKHG5_uc001anj.1_Silent_p.L213L|PLEKHG5_uc009vma.1_Silent_p.L492L|PLEKHG5_uc010nzr.1_Silent_p.L721L|PLEKHG5_uc001ank.1_Silent_p.L652L|PLEKHG5_uc009vmb.1_Silent_p.L652L|PLEKHG5_uc001anl.1_Silent_p.L652L|PLEKHG5_uc001anm.1_Silent_p.L652L|PLEKHG5_uc001anr.1_5'Flank	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	708	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GAAACTCATTCAGGTAGATAA	0.592													0	0	0	0.021022	0	39	140										T	6529488	C	T	6529488	2	4	79	1	0	0	0	0	0	0	0	1	12073	813	29	1		1	PLEKHG5	1	6529488	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	372714	6529488	242721133	3	23616										
SLC45A1	50651	broad.mit.edu	37	chr1	8385897	8385897	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggggcactgctgggcctctcGctcttgctgaatggccggga	16	12	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:8385897G>T	uc001apb.2	+	3	510	c.510G>T	c.(508-510)TCG>TCT	p.S170S		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	170	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGCCTCTCGCTCTTGCTGA	0.597													1	0	7.93312e-07	0.020292	8.4505e-07	14	60										T	8385897	G	T	8385897	2	4	79	1	0	0	0	0	0	0	0	1	14640	1074	38	4		4	SLC45A1	1	8385897	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1856409	8385897	240864724	4	23617										
GALE	2582	broad.mit.edu	37	chr1	24124667	24124667	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	taatccagaggcttctgcacCgactcgcccacggccttgag	10	15	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:24124667C>T	uc009vqo.1	-	4	501	c.291G>A	c.(289-291)TCG>TCA	p.S97S	GALE_uc001bhv.1_Silent_p.S97S|GALE_uc001bhw.1_Silent_p.S97S|GALE_uc001bhx.1_Silent_p.S97S|GALE_uc009vqp.1_Silent_p.S97S|GALE_uc001bhy.1_Silent_p.S97S|GALE_uc001bhz.1_Silent_p.S23S|GALE_uc001bia.2_5'Flank|GALE_uc009vqq.1_3'UTR	NM_001127621	NP_001121093	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	97					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GCTTCTGCACCGACTCGCCCA	0.562													0	0	0	0.014758	0	5	96										T	24124667	C	T	24124667	2	4	79	1	0	0	0	0	0	0	0	1	6202	639	23	2		2	GALE	1	24124667	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	15738770	24124667	225125954	5	23618										
SEPN1	57190	broad.mit.edu	37	chr1	26140386	26140386	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaacaggttcagggcggactCtccgggagactgtcctggaa	15	10	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:26140386C>T	uc010oer.1	+	14	1457	c.1402C>T	c.(1402-1404)CTC>TTC	p.L468F	SEPN1_uc010oes.1_Missense_Mutation_p.L434F	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	468						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCGGACTCTCCGGGAGAC	0.602													0	0	0	0.010729	0	11	67										T	26140386	C	T	26140386	3	4	79	1	0	0	0	0	1	0	0	0	14056	913	32	1	1444	1	SEPN1	1	26140386	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2015719	26140386	223110235	6	23619										
C1orf38	9473	broad.mit.edu	37	chr1	28208582	28208582	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tttatcaaaccgctgctgctGagcgaggtcctggcctggga	13	11	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:28208582G>A	uc001bpc.3	+	4	775	c.747G>A	c.(745-747)CTG>CTA	p.L249L	C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Silent_p.L249L	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	249	CABIT 2.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTGCTGCTGAGCGAGGTCC	0.637													0	0	0	0.00499	0	15	46										A	28208582	G	A	28208582	2	1	79	1	0	0	0	0	0	0	0	1	2039	1277	45	1		1	C1orf38	1	28208582	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2068196	28208582	221042039	7	23620										
ZMYM1	79830	broad.mit.edu	37	chr1	35580244	35580244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aaaaccttctcttcagaaaaGaagaaaaattcagaaatcag	5	7	4	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:35580244G>C	uc001bym.2	+	11	2961	c.2813G>C	c.(2812-2814)AGA>ACA	p.R938T	ZMYM1_uc001byn.2_Missense_Mutation_p.R938T|ZMYM1_uc010ohu.1_Missense_Mutation_p.R919T|ZMYM1_uc001byo.2_Missense_Mutation_p.R578T|ZMYM1_uc009vut.2_Missense_Mutation_p.R863T	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	938						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTCAGAAAAGAAGAAAAATT	0.284													0	0	0	0.014758	0	4	54										C	35580244	G	C	35580244	3	2	79	1	0	0	0	0	1	0	0	0	17696	942	33	1	2847	1	ZMYM1	1	35580244	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	7371662	35580244	213670377	8	23621										
KCNQ4	9132	broad.mit.edu	37	chr1	41282936	41282936	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tccctcatgttgtaattgcaGatttttgctggtcttcagct	8	9	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:41282936G>C	uc001cgh.1	+	2	397	c.315_splice	c.e2-1	p.I105_splice	KCNQ4_uc001cgi.1_Splice_Site_p.I105_splice	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein						sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TGTAATTGCAGATTTTTGCTG	0.522													0	0	0	0.009096	0	4	28										C	41282936	G	C	41282936	5	2	79	1	0	0	0	0	0	0	1	0	8085	956	33	1	320	1	KCNQ4	1	41282936	Splice_Site	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	5702692	41282936	207967685	9	23622										
SLC2A1	6513	broad.mit.edu	37	chr1	43395392	43395392	+	Missense_Mutation	SNP	C	C	T													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccgcatcatctgccgactctCttccttcatctcctgcaggt							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:43395392C>T	uc001cik.2	-	6	1264	c.739G>A	c.(739-741)GAG>AAG	p.E247K		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	247	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TGCCGACTCTCTTCCTTCATC	0.627													0	0	0	0.01441	0	60	124										T	43395392	C	T	43395392	3	4	79	1	0	0	0	0	1	0	0	0	14538	922	32	1	759	1	SLC2A1	1	43395392	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2112456	43395392	205855229	10	23623	119	2								
SLC2A1	6513	broad.mit.edu	37	chr1	43395395	43395395	+	Missense_Mutation	SNP	C	C	T													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	catcatctgccgactctcttCcttcatctcctgcaggtcat							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:43395395C>T	uc001cik.2	-	6	1261	c.736G>A	c.(736-738)GAA>AAA	p.E246K		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	246	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGACTCTCTTCCTTCATCTCC	0.622													0	0	0	0.01441	0	61	122										T	43395395	C	T	43395395	3	4	79	1	0	0	0	0	1	0	0	0	14538	864	30	1	762	1	SLC2A1	1	43395395	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3	43395395	205855226	11	23624	119	2								
MMACHC	25974	broad.mit.edu	37	chr1	45966020	45966020	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcgctatggagccgaaagtcGcagagctgaagcagaagatc	14	9	0	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:45966020G>T	uc009vxv.2	+	1	165	c.16G>T	c.(16-18)GCA>TCA	p.A6S	CCDC163P_uc001cnt.2_5'Flank|CCDC163P_uc001cnw.2_5'Flank|CCDC163P_uc001cnu.2_5'Flank|CCDC163P_uc009vxt.1_5'Flank|CCDC163P_uc001cnv.2_5'Flank|CCDC163P_uc009vxu.1_5'Flank|MMACHC_uc001cny.2_RNA	NM_015506	NP_056321	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency)	6							cobalamin binding				0	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCGAAAGTCGCAGAGCTGAA	0.512													1	0	3.52763e-06	0.00499	3.71159e-06	17	131										T	45966020	G	T	45966020	3	4	79	1	0	0	0	0	1	0	0	0	9641	1087	38	4	18	4	MMACHC	1	45966020	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2570625	45966020	203284601	12	23625										
SLC5A9	200010	broad.mit.edu	37	chr1	48701486	48701486	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aacagcagcagcaccctgttCaccattgatgtgtggcagcg	11	12	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:48701486C>T	uc001cro.2	+	10	1279	c.1227C>T	c.(1225-1227)TTC>TTT	p.F409F	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Silent_p.F434F|SLC5A9_uc010omt.1_Silent_p.F423F|SLC5A9_uc001crp.2_Silent_p.F76F|SLC5A9_uc010omu.1_Silent_p.F76F	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	409	Cytoplasmic (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						GCACCCTGTTCACCATTGATG	0.612													0	0	0	0.013726	0	30	48										T	48701486	C	T	48701486	2	4	79	1	0	0	0	0	0	0	0	1	14672	825	29	1		1	SLC5A9	1	48701486	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2735466	48701486	200549135	13	23626										
ORC1L	4998	broad.mit.edu	37	chr1	52861995	52861995	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagagtgtcttctcatttttCagattcgtcggtaccacatc	7	10	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:52861995C>T	uc001ctt.2	-	5	663	c.444G>A	c.(442-444)CTG>CTA	p.L148L	ORC1L_uc010oni.1_Silent_p.L148L|ORC1L_uc001ctu.2_Silent_p.L148L|ORC1L_uc009vzd.2_5'UTR	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	148	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						TCTCATTTTTCAGATTCGTCG	0.418													0	0	0	0.01441	0	63	77										T	52861995	C	T	52861995	2	4	79	1	0	0	0	0	0	0	0	1	11261	813	29	1		1	ORC1L	1	52861995	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	4160509	52861995	196388626	14	23627										
LEPR	3953	broad.mit.edu	37	chr1	66083712	66083712	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtgtgattgtttcctggataCtatcacccagtgattacaag	9	8	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:66083712C>G	uc001dci.2	+	16	2480	c.2278C>G	c.(2278-2280)CTA>GTA	p.L760V	LEPR_uc001dcg.2_Missense_Mutation_p.L760V|LEPR_uc001dch.2_Missense_Mutation_p.L760V|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.L760V|LEPR_uc001dck.2_Missense_Mutation_p.L760V	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	760	Extracellular (Potential).|Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTCCTGGATACTATCACCCAG	0.318													0	0	0	0.013537	0	13	55										G	66083712	C	G	66083712	3	3	79	1	0	0	0	0	1	0	0	0	8728	564	20	4	2332	4	LEPR	1	66083712	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	13221717	66083712	183166909	15	23628										
ST6GALNAC5	81849	broad.mit.edu	37	chr1	77516012	77516012	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcactggagctctgtgacagGatcaatgtttatggcatggt	13	7	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:77516012G>C	uc001dhi.2	+	4	916	c.741G>C	c.(739-741)AGG>AGC	p.R247S	ST6GALNAC5_uc010ori.1_3'UTR|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	247	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						TCTGTGACAGGATCAATGTTT	0.433													0	0	0	0.006999	0	40	82										C	77516012	G	C	77516012	3	2	79	1	0	0	0	0	1	0	0	0	15226	1165	41	1	755	1	ST6GALNAC5	1	77516012	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	11432300	77516012	171734609	16	23629										
PIGK	10026	broad.mit.edu	37	chr1	77629564	77629564	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acatttgttcaaaagcatccGcgagttctatgttggtaatt	8	7	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:77629564G>A	uc001dhk.2	-	6	596	c.551C>T	c.(550-552)GCG>GTG	p.A184V	PIGK_uc010orj.1_Missense_Mutation_p.A108V|PIGK_uc009wbx.2_Missense_Mutation_p.A90V|PIGK_uc001dhl.1_Missense_Mutation_p.A184V	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	184	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						AAAAGCATCCGCGAGTTCTAT	0.308													0	0	0	0.00499	0	15	40										A	77629564	G	A	77629564	3	1	79	1	0	0	0	0	1	0	0	0	11890	1087	38	2	660	2	PIGK	1	77629564	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	113552	77629564	171621057	17	23630										
RBM15	64783	broad.mit.edu	37	chr1	110882503	110882503	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttcctctggggccgcctcctCagctcccggcggcggggacg	15	17	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:110882503C>G	uc001dzl.1	+	1	559	c.476C>G	c.(475-477)TCA>TGA	p.S159*	RBM15_uc001dzm.1_Nonsense_Mutation_p.S159*|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	159	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCCGCCTCCTCAGCTCCCGGC	0.642			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	20	32										G	110882503	C	G	110882503	4	3	79	1	0	0	0	0	0	1	0	0	13116	838	29	1	478	1	RBM15	1	110882503	Nonsense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	33252939	110882503	138368118	18	23631										
OVGP1	5016	broad.mit.edu	37	chr1	111957832	111957832	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tccgtggatctcagtgacccCagcctctcctcctgggggca	11	16	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:111957832C>A	uc001eba.2	-	11	1347	c.1291G>T	c.(1291-1293)GGG>TGG	p.G431W	OVGP1_uc001eaz.2_Missense_Mutation_p.G393W|OVGP1_uc010owb.1_Missense_Mutation_p.G79W	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	431					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCAGTGACCCCAGCCTCTCCT	0.498													1	0	2.23348e-06	0.004007	2.35718e-06	15	77										A	111957832	C	A	111957832	3	1	79	1	0	0	0	0	1	0	0	0	11325	594	21	4	749	4	OVGP1	1	111957832	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1075329	111957832	137292789	19	23632										
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859361	149859361	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctccgcgtagttgcctttgcGcagcaagcggtgcactcgcc	12	15	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:149859361G>C	uc001ete.2	-	1	106	c.106C>G	c.(106-108)CGC>GGC	p.R36G	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	36					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTGCCTTTGCGCAGCAAGCGG	0.697													0	0	0	0.007413	0	20	99										C	149859361	G	C	149859361	3	2	79	1	0	0	0	0	1	0	0	0	7177	1087	38	4	290	4	HIST2H2AB	1	149859361	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	37901529	149859361	99391260	20	23633										
CGN	57530	broad.mit.edu	37	chr1	151491799	151491799	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggctttagccgttctcgtcaGactcaggactgggtccttca	11	12	4	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:151491799G>A	uc009wmw.2	+	2	948	c.804G>A	c.(802-804)CAG>CAA	p.Q268Q		NM_020770	NP_065821	Q9P2M7	CING_HUMAN	cingulin	262	Interacts with ZO-2.|Head.					myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTTCTCGTCAGACTCAGGACT	0.552													0	0	0	0.013537	0	13	31										A	151491799	G	A	151491799	2	1	79	1	0	0	0	0	0	0	0	1	3303	933	33	1		1	CGN	1	151491799	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1632438	151491799	97758822	21	23634										
TCHH	7062	broad.mit.edu	37	chr1	152080319	152080319	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcggaattttctgtcagactCttggctgcgcagctgctgtt	12	10	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:152080319C>G	uc001ezp.2	-	2	5374	c.5374G>C	c.(5374-5376)GAG>CAG	p.E1792Q	TCHH_uc009wne.1_Missense_Mutation_p.E1792Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1792	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCAGACTCTTGGCTGCGC	0.602													0	0	0	0.021523	0	25	75										G	152080319	C	G	152080319	3	3	79	1	0	0	0	0	1	0	0	0	15697	922	32	1	461	1	TCHH	1	152080319	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	588520	152080319	97170302	22	23635										
TCHH	7062	broad.mit.edu	37	chr1	152080442	152080442	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cggacggagctgctcttcctCtaggatttttctgtagcgtt	11	10	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:152080442C>G	uc001ezp.2	-	2	5251	c.5251G>C	c.(5251-5253)GAG>CAG	p.E1751Q	TCHH_uc009wne.1_Missense_Mutation_p.E1751Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1751	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCTTCCTCTAGGATTTTT	0.592													0	0	0	0.014323	0	23	69										G	152080442	C	G	152080442	3	3	79	1	0	0	0	0	1	0	0	0	15697	922	32	1	584	1	TCHH	1	152080442	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	123	152080442	97170179	23	23636										
SHE	126669	broad.mit.edu	37	chr1	154471660	154471660	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gactctctctgcatccctttGaccctttgtccgtttggcat	7	14	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:154471660G>A	uc001ffb.2	-	2	733	c.646C>T	c.(646-648)CAA>TAA	p.Q216*	SHE_uc001ffc.2_RNA	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	216										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCATCCCTTTGACCCTTTGTC	0.453													0	0	0	0.01892	0	26	62										A	154471660	G	A	154471660	4	1	79	1	0	0	0	0	0	1	0	0	14276	1299	45	1	861	1	SHE	1	154471660	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2391218	154471660	94778961	24	23637										
FCRL3	115352	broad.mit.edu	37	chr1	157650526	157650526	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtatgctggatgctccagatCtgggaataaatcgggttgct	13	7	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:157650526C>T	uc001frb.2	-	13	2284	c.1992G>A	c.(1990-1992)CAG>CAA	p.Q664Q	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.Q664Q|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.Q390Q|FCRL3_uc001frc.1_Silent_p.Q664Q	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	664	ITIM motif 2.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TGCTCCAGATCTGGGAATAAA	0.433													0	0	0	0.019004	0	31	53										T	157650526	C	T	157650526	2	4	79	1	0	0	0	0	0	0	0	1	5796	912	32	1		1	FCRL3	1	157650526	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3178866	157650526	91600095	25	23638										
CD244	51744	broad.mit.edu	37	chr1	160808273	160808273	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggttttcagatccttgacatCttcgtaaattgtcaaaaatt	6	7	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:160808273C>G	uc009wtq.2	-	5	995	c.817G>C	c.(817-819)GAT>CAT	p.D273H	CD244_uc001fxa.2_Missense_Mutation_p.D268H|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Missense_Mutation_p.D176H	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	273	Cytoplasmic (Potential).				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TCCTTGACATCTTCGTAAATT	0.453													0	0	0	0.01441	0	140	80										G	160808273	C	G	160808273	3	3	79	1	0	0	0	0	1	0	0	0	2987	913	32	1	315	1	CD244	1	160808273	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3157747	160808273	88442348	26	23639										
DEDD	9191	broad.mit.edu	37	chr1	161094073	161094073	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagtcacgtccatttcggatGagtccacgctcgtggtcatc	10	12	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:161094073G>A	uc001fxz.2	-	3	353	c.180C>T	c.(178-180)CTC>CTT	p.L60L	NIT1_uc001fxw.2_3'UTR|DEDD_uc009wty.2_Silent_p.L60L|DEDD_uc001fya.2_Silent_p.L60L|DEDD_uc001fyb.2_Silent_p.L60L|DEDD_uc010pkb.1_Intron|DEDD_uc001fyc.2_Intron	NM_001039712	NP_001034801	O75618	DEDD_HUMAN	death effector domain-containing protein	60	DED.				apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CATTTCGGATGAGTCCACGCT	0.527													0	0	0	0.01441	0	64	29										A	161094073	G	A	161094073	2	1	79	1	0	0	0	0	0	0	0	1	4384	1277	45	1		1	DEDD	1	161094073	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	285800	161094073	88156548	27	23640										
APOA2	336	broad.mit.edu	37	chr1	161193191	161193191	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agttgctgcgagcagcttcaTgttggtaacagtggggaggg	17	6	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:161193191T>C	uc001fzc.1	-	2	59	c.1A>G	c.(1-3)ATG>GTG	p.M1V	APOA2_uc001fzb.1_RNA|TOMM40L_uc010pkk.1_5'Flank|TOMM40L_uc010pkl.1_5'Flank|TOMM40L_uc001fzd.2_5'Flank|TOMM40L_uc009wue.2_5'Flank|TOMM40L_uc009wuf.1_5'Flank|TOMM40L_uc001fze.2_5'Flank	NM_001643	NP_001634	P02652	APOA2_HUMAN	apolipoprotein A-II preproprotein	1					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGCAGCTTCATGTTGGTAACA	0.582													0	0	0	0.004482	0	8	40										C	161193191	T	C	161193191	3	2	79	1	0	0	0	0	1	0	0	0	782	1464	51	5	313	5	APOA2	1	161193191	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	99118	161193191	88057430	28	23641										
PBX1	5087	broad.mit.edu	37	chr1	164769086	164769086	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agctcaagcagagcacgtgcGaggcggtgatgatcctgcgt	15	10	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:164769086G>A	uc001gct.2	+	4	919	c.661G>A	c.(661-663)GAG>AAG	p.E221K	PBX1_uc010pku.1_Missense_Mutation_p.E221K|PBX1_uc010pkv.1_Missense_Mutation_p.E138K|PBX1_uc001gcs.2_Missense_Mutation_p.E221K|PBX1_uc010pkw.1_Missense_Mutation_p.E111K	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	221					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						GAGCACGTGCGAGGCGGTGAT	0.612			T	TCF3|EWSR1	pre B-ALL|myoepithelioma								0	0	0	0.004482	0	8	112										A	164769086	G	A	164769086	3	1	79	1	0	0	0	0	1	0	0	0	11492	1059	37	1	675	1	PBX1	1	164769086	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	3575895	164769086	84481535	29	23642										
PAPPA2	60676	broad.mit.edu	37	chr1	176564283	176564283	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aattgatctcccagtacaatGgatactggccccttcgggga	10	11	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:176564283G>T	uc001gkz.2	+	3	2707	c.1543G>T	c.(1543-1545)GGA>TGA	p.G515*	PAPPA2_uc001gky.1_Nonsense_Mutation_p.G515*|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	515	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCAGTACAATGGATACTGGCC	0.537													1	0	5.50884e-06	0.013537	5.74326e-06	13	118										T	176564283	G	T	176564283	4	4	79	1	0	0	0	0	0	1	0	0	11433	1349	47	4	1549	4	PAPPA2	1	176564283	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	11795197	176564283	72686338	30	23643										
PAPPA2	60676	broad.mit.edu	37	chr1	176659424	176659424	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccctgcaaggagacagtgccAtccatggaaacgggagacct	12	12	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:176659424A>G	uc001gkz.2	+	5	3453	c.2289A>G	c.(2287-2289)CCA>CCG	p.P763P	PAPPA2_uc001gky.1_Silent_p.P763P|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	763					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGACAGTGCCATCCATGGAAA	0.552													0	0	0	0.008871	0	19	339										G	176659424	A	G	176659424	2	3	79	1	0	0	0	0	0	0	0	1	11433	204	8	5		5	PAPPA2	1	176659424	Silent	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	95141	176659424	72591197	31	23644										
ZBTB41	360023	broad.mit.edu	37	chr1	197160945	197160945	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttctgtgaacagttaggttaGactttgttgaatagcgctgg	12	5	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:197160945G>C	uc001gtx.1	-	2	1274	c.1205C>G	c.(1204-1206)TCT>TGT	p.S402C	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	402	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGTTAGGTTAGACTTTGTTGA	0.378													0	0	0	0.006214	0	10	28										C	197160945	G	C	197160945	3	2	79	1	0	0	0	0	1	0	0	0	17540	942	33	1	1560	1	ZBTB41	1	197160945	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	20501521	197160945	52089676	32	23645										
KDM5B	10765	broad.mit.edu	37	chr1	202702685	202702685	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctttcaatcatatatcgaagTgcatctccctcaggaaggcg	8	11	4	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:202702685T>A	uc001gyf.2	-	23	3869	c.3753A>T	c.(3751-3753)GCA>GCT	p.A1251A	KDM5B_uc009xag.2_Silent_p.A1287A|KDM5B_uc001gyg.1_Silent_p.A1093A	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1251					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TATATCGAAGTGCATCTCCCT	0.512													0	0	0	0.016723	0	14	57										A	202702685	T	A	202702685	2	1	79	1	0	0	0	0	0	0	0	1	8134	1683	59	5		5	KDM5B	1	202702685	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	5541740	202702685	46547936	33	23646										
PPM1G	5496	broad.mit.edu	37	chr2	27608625	27608625	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacactcaccatcatcttcaTcagctactttttctttttca	1	14	7	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:27608625T>A	uc002rkl.2	-	5	505	c.398A>T	c.(397-399)GAT>GTT	p.D133V	PPM1G_uc002rkm.2_5'UTR	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	133					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ATCATCTTCATCAGCTACTTT	0.393													0	0	0	0.019004	0	32	66										A	27608625	T	A	27608625	3	1	79	1	0	0	0	0	1	0	0	0	12340	1435	50	5	1270	5	PPM1G	2	27608625	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08		27608625	215590748	34	23647										
SUPT7L	9913	broad.mit.edu	37	chr2	27876591	27876591	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacatgggccagattccaaaGaggagaagcatttacctctg	10	10	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:27876591G>C	uc002rlh.1	-	6	1349	c.1006C>G	c.(1006-1008)CTT>GTT	p.L336V	SUPT7L_uc002rli.1_Missense_Mutation_p.L336V|SUPT7L_uc010ymf.1_Missense_Mutation_p.L201V|SUPT7L_uc002rlj.1_Missense_Mutation_p.L334V|SUPT7L_uc010ezh.1_Missense_Mutation_p.L334V	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	336					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					AGATTCCAAAGAGGAGAAGCA	0.448													0	0	0	0.006999	0	39	93										C	27876591	G	C	27876591	3	2	79	1	0	0	0	0	1	0	0	0	15398	942	33	1	242	1	SUPT7L	2	27876591	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	267966	27876591	215322782	35	23648										
XDH	7498	broad.mit.edu	37	chr2	31591514	31591514	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacagcaccaatgatatgccCaacacaagtaacctagtagc	6	13	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:31591514C>T	uc002rnv.1	-	19	2072	c.1993G>A	c.(1993-1995)GGG>AGG	p.G665R		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	665					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ATGATATGCCCAACACAAGTA	0.443													0	0	0	0.00632	0	26	66										T	31591514	C	T	31591514	3	4	79	1	0	0	0	0	1	0	0	0	17423	594	21	2	2080	2	XDH	2	31591514	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3714923	31591514	211607859	36	23649										
MTIF2	4528	broad.mit.edu	37	chr2	55479634	55479634	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctgtgcatctttggcatgctGaatagattctacagtttgtt	9	7	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:55479634G>C	uc002ryn.2	-	9	1557	c.820C>G	c.(820-822)CAG>GAG	p.Q274E	MTIF2_uc010yox.1_Intron|MTIF2_uc002ryo.2_Missense_Mutation_p.Q274E	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	274	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						TTGGCATGCTGAATAGATTCT	0.393													0	0	0	0.012213	0	28	74										C	55479634	G	C	55479634	3	2	79	1	0	0	0	0	1	0	0	0	9934	1299	45	1	1399	1	MTIF2	2	55479634	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	23888120	55479634	187719739	37	23650										
PPP3R1	5534	broad.mit.edu	37	chr2	68408096	68408096	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tggtactctctgataagagtCacacatctaccaccatcttt	5	12	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:68408096C>G	uc002sei.1	-	6	904	c.512G>C	c.(511-513)TGA>TCA	p.*171S		NM_000945	NP_000936	P63098	CANB1_HUMAN	protein phosphatase 3, regulatory subunit B,	171					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding				0					Pimecrolimus(DB00337)	TGATAAGAGTCACACATCTAC	0.433													0	0	0	0.001168	0	5	23										G	68408096	C	G	68408096	4	3	79	1	0	0	0	0	0	0	0	0	12400	837	29	1	4	1	PPP3R1	2	68408096	Nonstop_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	12928462	68408096	174791277	38	23651										
MXD1	4084	broad.mit.edu	37	chr2	70164512	70164512	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caccgtctcctcggagcgctCcgactccgacaggggtgagc	13	16	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:70164512C>G	uc002sfy.2	+	5	724	c.464C>G	c.(463-465)TCC>TGC	p.S155C	MXD1_uc010yqp.1_Missense_Mutation_p.S155C|MXD1_uc010yqq.1_Missense_Mutation_p.S92C|MXD1_uc010yqr.1_RNA|MXD1_uc010yqs.1_Missense_Mutation_p.S145C	NM_002357	NP_002348	Q05195	MAD1_HUMAN	MAX dimerization protein 1	155					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						TCGGAGCGCTCCGACTCCGAC	0.627													0	0	0	0.006122	0	19	42										G	70164512	C	G	70164512	3	3	79	1	0	0	0	0	1	0	0	0	9999	855	30	1	482	1	MXD1	2	70164512	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1756416	70164512	173034861	39	23652										
ZAP70	7535	broad.mit.edu	37	chr2	98340656	98340656	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	atgtgctgtcgctcgtgcacGatgtgcgcttccaccacttt	10	13	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:98340656G>C	uc002syd.1	+	3	364	c.157G>C	c.(157-159)GAT>CAT	p.D53H	ZAP70_uc010yvf.1_Missense_Mutation_p.D53H|ZAP70_uc002sye.1_5'Flank	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	53	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GCTCGTGCACGATGTGCGCTT	0.672													0	0	0	0.013537	0	13	11										C	98340656	G	C	98340656	3	2	79	1	0	0	0	0	1	0	0	0	17511	1058	37	1	159	1	ZAP70	2	98340656	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	28176144	98340656	144858717	40	23653										
MGAT4A	11320	broad.mit.edu	37	chr2	99294780	99294780	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tttgtacctgaaaacttattCaacgcatccttacttccatt	3	11	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294780C>G	uc002sze.2	-	3	563	c.249G>C	c.(247-249)TTG>TTC	p.L83F	MGAT4A_uc010fil.2_5'UTR	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	83	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						AAAACTTATTCAACGCATCCT	0.249													0	0	0	0.004007	0	17	108										G	99294780	C	G	99294780	3	3	79	1	0	0	0	0	1	0	0	0	9545	825	29	1	1516	1	MGAT4A	2	99294780	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	954124	99294780	143904593	41	23654										
MGAT4A	11320	broad.mit.edu	37	chr2	99294910	99294911	+	Missense_Mutation	DNP	TC	TC	AT													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gttctttcaaagcaaggaatTctcgttgataagcaatcagt							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294910_99294911TC>AT	uc002sze.2	-	3	432_433	c.118_119GA>AT	c.(118-120)GAA>ATA	p.E40I	MGAT4A_uc010fil.2_5'UTR	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	40	Lumenal (Potential).|Potential.				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						AGCAAGGAATTCTCGTTGATAA	0.337													0	0	0	0.004672	0	18	85										AT	99294911	TC	AT	99294910	3	1	79	1	0	0	0	0	1	0	0	0	9545	1783	62	5	1646	5	MGAT4A	2	99294910	Missense_Mutation	DNP	TC	TCGA-FD-A3SJ-01A-12D-A22Z-08	130	99294910	143904463	42	23655										
GLI2	2736	broad.mit.edu	37	chr2	121744054	121744054	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tccgctggtggcctccagctGcgcaaacacatgaccaccat	9	16	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:121744054G>A	uc010flp.2	+	12	2187	c.2157G>A	c.(2155-2157)CTG>CTA	p.L719L	GLI2_uc002tmq.1_Silent_p.L391L|GLI2_uc002tmr.1_Silent_p.L374L|GLI2_uc002tmt.3_Silent_p.L391L|GLI2_uc002tmu.3_Silent_p.L374L|GLI2_uc002tmw.1_Silent_p.L702L	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	719				QL -> HV (in Ref. 4; BAA03568/BAA03569).	axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCCTCCAGCTGCGCAAACACA	0.657													0	0	0	0.001168	0	6	21										A	121744054	G	A	121744054	2	1	79	1	0	0	0	0	0	0	0	1	6438	1306	46	2		2	GLI2	2	121744054	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	22449144	121744054	121455319	43	23656										
ERCC3	2071	broad.mit.edu	37	chr2	128036775	128036775	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agtcgaatggcatattccttTagggcaaacacattgtcagc	9	9	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:128036775T>C	uc002toh.1	-	10	1799	c.1704A>G	c.(1702-1704)CTA>CTG	p.L568L	ERCC3_uc002toe.1_Silent_p.L323L|ERCC3_uc002tof.1_Silent_p.L504L|ERCC3_uc002tog.1_Silent_p.L504L	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	568	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CATATTCCTTTAGGGCAAACA	0.428			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.00499	0	17	22										C	128036775	T	C	128036775	2	2	79	1	0	0	0	0	0	0	0	1	5214	1741	61	5		5	ERCC3	2	128036775	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	6292721	128036775	115162598	44	23657										
GPR17	2840	broad.mit.edu	37	chr2	128408390	128408390	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gagcaatgtggccaggagacGccactggagaacatgctgtt	14	9	0	2	rs145234598		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:128408390G>A	uc010yzn.1	+	4	776	c.165G>A	c.(163-165)ACG>ACA	p.T55T	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.T55T|GPR17_uc010yzo.1_Silent_p.T27T|GPR17_uc002tpd.2_Silent_p.T27T	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	55	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		gccaggagacgccactggaga	0.1											OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.020292	0	14	56										A	128408390	G	A	128408390	2	1	79	1	0	0	0	0	0	0	0	1	6667	1074	38	2		2	GPR17	2	128408390	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	371615	128408390	114790983	45	23658										
TTN	7273	broad.mit.edu	37	chr2	179448568	179448568	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	actgcctccatcatgctttgGacgagcccagatcagagata	9	12	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:179448568G>C	uc010zfg.1	-	261	57861	c.57637C>G	c.(57637-57639)CCA>GCA	p.P19213A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P12908A|TTN_uc010zfi.1_Missense_Mutation_p.P12841A|TTN_uc010zfj.1_Missense_Mutation_p.P12716A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20140							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATGCTTTGGACGAGCCCAG	0.428													0	0	0	0.001168	0	6	10										C	179448568	G	C	179448568	3	2	79	1	0	0	0	0	1	0	0	0	16732	1174	41	1	42842	1	TTN	2	179448568	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	51040178	179448568	63750805	46	23659										
FN1	2335	broad.mit.edu	37	chr2	216237060	216237060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caagatctctggtccatgaaGattggggtgtggaagggtta	15	5	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:216237060G>C	uc002vfa.2	-	40	6552	c.6286C>G	c.(6286-6288)CTT>GTT	p.L2096V	FN1_uc002vfb.2_Missense_Mutation_p.L1915V|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Missense_Mutation_p.L2005V|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Missense_Mutation_p.L1915V|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Missense_Mutation_p.L2096V|FN1_uc002vfj.2_Intron|FN1_uc002vez.2_Missense_Mutation_p.L290V|FN1_uc010zjp.1_Missense_Mutation_p.L633V|FN1_uc002vfk.1_Intron|FN1_uc010fva.1_Intron|FN1_uc010fvb.1_Intron|FN1_uc010fvc.1_Intron|FN1_uc010fvd.1_Missense_Mutation_p.L187V	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2005	Connecting strand 3 (CS-3) (V region).				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTCCATGAAGATTGGGGTGT	0.502													0	0	0	0.015359	0	34	29										C	216237060	G	C	216237060	3	2	79	1	0	0	0	0	1	0	0	0	5962	942	33	1	1175	1	FN1	2	216237060	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	36788492	216237060	26962313	47	23660										
SPEG	10290	broad.mit.edu	37	chr2	220326632	220326632	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acatcccctttcagcagcccCatcacctccgacgaggaata	6	17	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:220326632C>G	uc010fwg.2	+	7	2469	c.2469C>G	c.(2467-2469)CCC>CCG	p.P823P	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Silent_p.P31P|SPEG_uc002vln.1_Silent_p.P31P|SPEG_uc002vlp.1_Silent_p.P31P|SPEG_uc002vlq.2_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	823					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCAGCAGCCCCATCACCTCCG	0.627													0	0	0	0.019004	0	36	46										G	220326632	C	G	220326632	2	3	79	1	0	0	0	0	0	0	0	1	15035	581	21	4		4	SPEG	2	220326632	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	4089572	220326632	22872741	48	23661										
ITM2C	81618	broad.mit.edu	37	chr2	231738161	231738161	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cccccacaacatcgatccaaGagggggggctcagtgggcgg	15	13	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:231738161G>C	uc002vqz.2	+	2	270	c.150G>C	c.(148-150)AAG>AAC	p.K50N	ITM2C_uc002vra.2_Intron|ITM2C_uc002vrb.2_Missense_Mutation_p.K50N|ITM2C_uc002vrc.2_5'Flank|ITM2C_uc002vrd.2_5'Flank	NM_030926	NP_112188	Q9NQX7	ITM2C_HUMAN	integral membrane protein 2C isoform 1	50					negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding				0		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		ATCGATCCAAGAGGGGGGGCT	0.612													0	0	0	0.001168	0	6	27										C	231738161	G	C	231738161	3	2	79	1	0	0	0	0	1	0	0	0	7914	933	33	1	156	1	ITM2C	2	231738161	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	11411529	231738161	11461212	49	23662										
COL6A3	1293	broad.mit.edu	37	chr2	238303321	238303321	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagtttcctactatgtcatgAagtgaggtaaaattctctag	8	6	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:238303321A>C	uc002vwl.2	-	3	903	c.618T>G	c.(616-618)CTT>CTG	p.L206L	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Silent_p.L206L	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	206	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTATGTCATGAAGTGAGGTAA	0.433													0	0	0	0.008291	0	11	37										C	238303321	A	C	238303321	2	2	79	1	0	0	0	0	0	0	0	1	3701	233	9	5		5	COL6A3	2	238303321	Silent	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	6565160	238303321	4896052	50	23663										
CLASP2	23122	broad.mit.edu	37	chr3	33626305	33626305	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gctccgtggtatcttgcttcTtttttgtgctgaggctgaat	11	8	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:33626305T>C	uc003cfu.2	-	22	2530	c.2176A>G	c.(2176-2178)AGA>GGA	p.R726G	CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.R319G	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	727										ovary(3)|central_nervous_system(1)	4						ATCTTGCTTCTTTTTTGTGCT	0.473													0	0	0	0.008361	0	31	38										C	33626305	T	C	33626305	3	2	79	1	0	0	0	0	1	0	0	0	3455	1617	56	5	2412	5	CLASP2	3	33626305	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08		33626305	164396125	51	23664										
SCN10A	6336	broad.mit.edu	37	chr3	38743492	38743492	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cgtcttttcttcactttggtCatcagtctccaccatcatgg	6	13	7	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743492C>G	uc003ciq.2	-	26	4495	c.4495G>C	c.(4495-4497)GAC>CAC	p.D1499H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1499	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCACTTTGGTCATCAGTCTCC	0.458													0	0	0	0.009535	0	31	89										G	38743492	C	G	38743492	3	3	79	1	0	0	0	0	1	0	0	0	13912	826	29	1	1383	1	SCN10A	3	38743492	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	5117187	38743492	159278938	52	23665			1	106		3	3	110	C		4.574683e-07
SCN10A	6336	broad.mit.edu	37	chr3	38743576	38743576	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agcttgtctggtcacgatgtCaaagacaaaaccctggaact	9	10	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743576C>G	uc003ciq.2	-	26	4411	c.4411G>C	c.(4411-4413)GAC>CAC	p.D1471H		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1471	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTCACGATGTCAAAGACAAAA	0.458													0	0	0	0.007413	0	17	80										G	38743576	C	G	38743576	3	3	79	1	0	0	0	0	1	0	0	0	13912	826	29	1	1467	1	SCN10A	3	38743576	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	84	38743576	159278854	53	23666			1	106		3	3	110	C		4.574683e-07
SCN10A	6336	broad.mit.edu	37	chr3	38743601	38743601	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acaaaaccctggaacttgttCtgagaaaacaagagatagtg	9	7	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743601C>G	uc003ciq.2	-	26	4387	c.4387_splice	c.e26-1	p.N1463_splice		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha						sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGAACTTGTTCTGAGAAAACA	0.468													0	0	0	0.00499	0	16	66										G	38743601	C	G	38743601	5	3	79	1	0	0	0	0	0	0	1	0	13912	927	32	1	1492	1	SCN10A	3	38743601	Splice_Site	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	25	38743601	159278829	54	23667			1	106		3	3	110	C		4.574683e-07
NKTR	4820	broad.mit.edu	37	chr3	42678832	42678832	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caaagtcctcatcacattctCgaagtagatcaaagtccaga	6	11	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:42678832C>G	uc003clo.2	+	13	1783	c.1636C>G	c.(1636-1638)CGA>GGA	p.R546G	NKTR_uc003clm.1_Missense_Mutation_p.R293G|NKTR_uc003clp.2_Missense_Mutation_p.R293G|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R436G|NKTR_uc003clr.1_Missense_Mutation_p.R293G|NKTR_uc003cls.2_Missense_Mutation_p.R246G	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	546	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		ATCACATTCTCGAAGTAGATC	0.418													0	0	0	0.005524	0	39	117										G	42678832	C	G	42678832	3	3	79	1	0	0	0	0	1	0	0	0	10448	876	31	1	1682	1	NKTR	3	42678832	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3935231	42678832	155343598	55	23668										
IQCF2	389123	broad.mit.edu	37	chr3	51895685	51895685	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	accatctaaggacaggccatGagggttcgattttgtgtaag	12	7	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:51895685G>C	uc003dbt.1	+	1	41	c.3G>C	c.(1-3)ATG>ATC	p.M1I	IQCF1_uc003dbq.3_Intron|IQCF2_uc003dbu.1_RNA	NM_203424	NP_982248	Q8IXL9	IQCF2_HUMAN	IQ motif containing F2	1											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GACAGGCCATGAGGGTTCGAT	0.483													0	0	0	0.010504	0	18	26										C	51895685	G	C	51895685	3	2	79	1	0	0	0	0	1	0	0	0	7808	1290	45	1	5	1	IQCF2	3	51895685	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	9216853	51895685	146126745	56	23669										
FLNB	2317	broad.mit.edu	37	chr3	58088057	58088057	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggggagctcggtgtaaccatGaagggtcctagtaagtgttc	15	7	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:58088057G>A	uc003djj.2	+	9	1638	c.1473G>A	c.(1471-1473)ATG>ATA	p.M491I	FLNB_uc010hne.2_Missense_Mutation_p.M491I|FLNB_uc003djk.2_Missense_Mutation_p.M491I|FLNB_uc010hnf.2_Missense_Mutation_p.M491I|FLNB_uc003djl.2_Missense_Mutation_p.M322I|FLNB_uc003djm.2_Missense_Mutation_p.M322I	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	491	Filamin 3.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GTGTAACCATGAAGGGTCCTA	0.522													0	0	0	0.013726	0	35	47										A	58088057	G	A	58088057	3	1	79	1	0	0	0	0	1	0	0	0	5934	1290	45	1	1507	1	FLNB	3	58088057	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	6192372	58088057	139934373	57	23670										
IMPG2	50939	broad.mit.edu	37	chr3	100992518	100992518	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttccccaaaaggtggatactGaattctgcaatctgttcacc	7	11	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:100992518G>A	uc003duq.1	-	7	938	c.735C>T	c.(733-735)TTC>TTT	p.F245F	IMPG2_uc011bhe.1_Silent_p.F108F	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	245	Extracellular (Potential).|SEA 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGTGGATACTGAATTCTGCAA	0.403													0	0	0	0.008291	0	11	24										A	100992518	G	A	100992518	2	1	79	1	0	0	0	0	0	0	0	1	7729	1281	45	1		1	IMPG2	3	100992518	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	42904461	100992518	97029912	58	23671										
COPG	22820	broad.mit.edu	37	chr3	128979195	128979195	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtgctccagcttttctgcagCtcacccaaggctgctctccg	9	16	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:128979195C>T	uc003els.2	+	11	991	c.891C>T	c.(889-891)AGC>AGT	p.S297S	COPG_uc010htb.2_Silent_p.S203S	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	297	HEAT 2.				COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						TTTTCTGCAGCTCACCCAAGG	0.562													0	0	0	0.021523	0	21	101										T	128979195	C	T	128979195	2	4	79	1	0	0	0	0	0	0	0	1	3731	796	28	2		2	COPG	3	128979195	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	27986677	128979195	69043235	59	23672										
SLCO2A1	6578	broad.mit.edu	37	chr3	133698434	133698434	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgtacaggagttggcagagcTgcaggaggccttggcagagc	17	8	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:133698434T>A	uc003eqa.3	-	2	399	c.125A>T	c.(124-126)CAG>CTG	p.Q42L	SLCO2A1_uc003eqb.3_Missense_Mutation_p.Q42L|SLCO2A1_uc011blv.1_Missense_Mutation_p.Q42L|SLCO2A1_uc010htw.1_5'UTR	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	42	Helical; Name=1; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						TTGGCAGAGCTGCAGGAGGCC	0.587													0	0	0	0.00632	0	27	74										A	133698434	T	A	133698434	3	1	79	1	0	0	0	0	1	0	0	0	14726	1580	55	5	1858	5	SLCO2A1	3	133698434	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	4719239	133698434	64323996	60	23673										
STAG1	10274	broad.mit.edu	37	chr3	136192446	136192446	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	attggtatatagactctgcaGagctttcaaacacttcagcc	7	10	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:136192446G>C	uc003era.1	-	11	1352	c.1060C>G	c.(1060-1062)CTG>GTG	p.L354V	STAG1_uc003erb.1_Missense_Mutation_p.L354V|STAG1_uc003erc.1_Missense_Mutation_p.L128V|STAG1_uc010hua.1_Missense_Mutation_p.L217V	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	354	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						AGACTCTGCAGAGCTTTCAAA	0.338													0	0	0	0.014323	0	22	49										C	136192446	G	C	136192446	3	2	79	1	0	0	0	0	1	0	0	0	15241	933	33	1	2812	1	STAG1	3	136192446	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2494012	136192446	61829984	61	23674										
PLOD2	5352	broad.mit.edu	37	chr3	145790403	145790403	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccatttcttctaccaattcaTcacaggctttttcagaaaat	3	11	5	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:145790403T>A	uc003evs.1	-	16	2236	c.1730A>T	c.(1729-1731)GAT>GTT	p.D577V	PLOD2_uc003evq.1_Missense_Mutation_p.D258V|PLOD2_uc011bnm.1_Missense_Mutation_p.D543V|PLOD2_uc003evr.1_Missense_Mutation_p.D598V	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	577					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	TACCAATTCATCACAGGCTTT	0.343													0	0	0	0.016723	0	12	39										A	145790403	T	A	145790403	3	1	79	1	0	0	0	0	1	0	0	0	12102	1435	50	5	499	5	PLOD2	3	145790403	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	9597957	145790403	52232027	62	23675										
ZIC1	7545	broad.mit.edu	37	chr3	147128322	147128322	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acggacgccgcgggccacctCctcttccccgggcttcacga	11	19	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:147128322C>G	uc003ewe.2	+	1	1142	c.423C>G	c.(421-423)CTC>CTG	p.L141L		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	141					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CGGGCCACCTCCTCTTCCCCG	0.726													0	0	0	0.004672	0	3	18										G	147128322	C	G	147128322	2	3	79	1	0	0	0	0	0	0	0	1	17675	842	30	1		1	ZIC1	3	147128322	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1337919	147128322	50894108	63	23676										
TNIK	23043	broad.mit.edu	37	chr3	170858210	170858210	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gttcatgctccgcacgcctcCtctcctcctcccggcgcatc	7	21	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:170858210C>T	uc003fhh.2	-	13	1655	c.1310G>A	c.(1309-1311)AGG>AAG	p.R437K	TNIK_uc003fhi.2_Missense_Mutation_p.R437K|TNIK_uc003fhj.2_Missense_Mutation_p.R437K|TNIK_uc003fhk.2_Missense_Mutation_p.R437K|TNIK_uc003fhl.2_Missense_Mutation_p.R437K|TNIK_uc003fhm.2_Missense_Mutation_p.R437K|TNIK_uc003fhn.2_Missense_Mutation_p.R437K|TNIK_uc003fho.2_Missense_Mutation_p.R437K	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	437	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CGCACGCCTCCTCTCCTCCTC	0.662													0	0	0	0.01441	0	52	108										T	170858210	C	T	170858210	3	4	79	1	0	0	0	0	1	0	0	0	16310	681	24	2	2856	2	TNIK	3	170858210	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	23729888	170858210	27164220	64	23677										
PIK3CA	5290	broad.mit.edu	37	chr3	178952085	178952085	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaaacaaatgaatgatgcacAtcatggtggctggacaacaa	10	7	1	2	rs121913279		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:178952085A>T	uc003fjk.2	+	21	3297	c.3140A>T	c.(3139-3141)CAT>CTT	p.H1047L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1269)|p.H1047L(152)|p.H1047Y(31)|p.H1047Q(3)|p.H1047T(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378	H1047R(BT20_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(MCAS_OVARY)|H1047R(HCC1954_BREAST)|H1047R(RKO_LARGE_INTESTINE)|H1047L(EFM19_BREAST)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(CAL29_URINARY_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(T47D_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(SKOV3_OVARY)|H1047R(MDAMB453_BREAST)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.005524	0	41	55										T	178952085	A	T	178952085	3	4	79	1	0	0	0	0	1	0	0	0	11913	217	8	5	3218	5	PIK3CA	3	178952085	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	8093875	178952085	19070345	65	23678										
HGFAC	3083	broad.mit.edu	37	chr4	3446124	3446124	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agggccacgtggaacagtgcGagtgcttcgggggccggacc	18	11	0	0	rs138611679		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:3446124G>C	uc003ghc.2	+	6	688	c.685G>C	c.(685-687)GAG>CAG	p.E229Q	HGFAC_uc010icw.2_Missense_Mutation_p.E229Q	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	229	Fibronectin type-I.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGAACAGTGCGAGTGCTTCGG	0.677													0	0	0	0.004672	0	3	6										C	3446124	G	C	3446124	3	2	79	1	0	0	0	0	1	0	0	0	7086	1059	37	1	707	1	HGFAC	4	3446124	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		3446124	187708152	66	23679										
RELL1	768211	broad.mit.edu	37	chr4	37687844	37687844	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggagccaccagcggcgaactCacggcgcctcccacgaagac	12	17	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:37687844C>T	uc003gsz.2	-	1	156	c.66G>A	c.(64-66)GTG>GTA	p.V22V	RELL1_uc010ifc.2_Silent_p.V22V	NM_001085399	NP_001078868	Q8IUW5	RELL1_HUMAN	receptor expressed in lymphoid tissues like 1	22						cytoplasm|integral to membrane|microtubule cytoskeleton|plasma membrane					0						GCGGCGAACTCACGGCGCCTC	0.761													0	0	0	0.014758	0	3	8										T	37687844	C	T	37687844	2	4	79	1	0	0	0	0	0	0	0	1	13218	813	29	1		1	RELL1	4	37687844	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	34241720	37687844	153466432	67	23680										
AASDH	132949	broad.mit.edu	37	chr4	57221444	57221444	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cattaaatatttgtgttttaTtgccttctcctctccagctt	4	10	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:57221444T>C	uc003hbn.2	-	6	1160	c.1007A>G	c.(1006-1008)AAT>AGT	p.N336S	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Missense_Mutation_p.N183S|AASDH_uc003hbo.2_Missense_Mutation_p.N236S|AASDH_uc011cab.1_5'UTR|AASDH_uc010ihc.2_Missense_Mutation_p.N336S|AASDH_uc003hbp.2_Missense_Mutation_p.N336S	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	336					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TTGTGTTTTATTGCCTTCTCC	0.403													0	0	0	0.010818	0	31	139										C	57221444	T	C	57221444	3	2	79	1	0	0	0	0	1	0	0	0	22	1493	52	5	2329	5	AASDH	4	57221444	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	19533600	57221444	133932832	68	23681										
ENAM	10117	broad.mit.edu	37	chr4	71500192	71500193	+	Missense_Mutation	DNP	CC	CC	AA													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caagaaacccagaaacccaaCcagactcagtcaaaaaagcc							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500192_71500193CC>AA	uc011caw.1	+	6	659_660	c.378_379CC>AA	c.(376-381)AACCAG>AAAAAG	p.126_127NQ>KK		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	126_127					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AGAAACCCAACCAGACTCAGTC	0.52													0	0	0	0.004672	0	11	24										AA	71500193	CC	AA	71500192	3	1	79	1	0	0	0	0	1	0	0	0	5112	506	18	4	396	4	ENAM	4	71500192	Missense_Mutation	DNP	CC	TCGA-FD-A3SJ-01A-12D-A22Z-08	14278748	71500192	119654084	69	23682	120	2								
ENAM	10117	broad.mit.edu	37	chr4	71500195	71500195	+	Silent	SNP	G	G	A													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaaacccagaaacccaaccaGactcagtcaaaaaagccacc							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500195G>A	uc011caw.1	+	6	662	c.381G>A	c.(379-381)CAG>CAA	p.Q127Q		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	127					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AACCCAACCAGACTCAGTCAA	0.522													0	0	0	0.012319	0	11	23										A	71500195	G	A	71500195	2	1	79	1	0	0	0	0	0	0	0	1	5112	933	33	1		1	ENAM	4	71500195	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	3	71500195	119654081	70	23683	120	2								
GK2	2712	broad.mit.edu	37	chr4	80328580	80328580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tactaatgcagcacattggtCccccaaacacccagatattg	6	13	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:80328580C>T	uc003hlu.2	-	1	793	c.775G>A	c.(775-777)GAC>AAC	p.D259N		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	259		Substrate (By similarity).			glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						GCACATTGGTCCCCCAAACAC	0.458													0	0	0	0.00632	0	29	68										T	80328580	C	T	80328580	3	4	79	1	0	0	0	0	1	0	0	0	6421	855	30	1	890	1	GK2	4	80328580	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	8828385	80328580	110825696	71	23684										
GALNTL6	442117	broad.mit.edu	37	chr4	173150860	173150860	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tattcatggacagatggtttGagaagaaaggactggcatga	13	4	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:173150860G>C	uc003isv.2	+	3	928	c.192G>C	c.(190-192)TTG>TTC	p.L64F		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	64	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						CAGATGGTTTGAGAAGAAAGG	0.443													0	0	0	0.00308	0	7	23										C	173150860	G	C	173150860	3	2	79	1	0	0	0	0	1	0	0	0	6225	1281	45	1	198	1	GALNTL6	4	173150860	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	92822280	173150860	18003416	72	23685										
BRD9	65980	broad.mit.edu	37	chr5	887497	887497	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttgctcatcatcttaaagccTgcgtgaaggatcttcttcgc	8	11	5	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:887497T>A	uc003jbq.2	-	6	863	c.696A>T	c.(694-696)GCA>GCT	p.A232A	BRD9_uc003jbl.2_Silent_p.A116A|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Silent_p.A179A|BRD9_uc003jbo.2_Silent_p.A116A|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	232							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			TCTTAAAGCCTGCGTGAAGGA	0.498													0	0	0	0.005443	0	23	130										A	887497	T	A	887497	2	1	79	1	0	0	0	0	0	0	0	1	1507	1567	55	5		5	BRD9	5	887497	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08		887497	180027763	73	23686										
LPCAT1	79888	broad.mit.edu	37	chr5	1479749	1479749	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tacgaacctcgatttccactTggttgtgaaactgacacagc	8	11	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:1479749T>A	uc003jcm.2	-	8	920	c.803A>T	c.(802-804)CAA>CTA	p.Q268L		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	268	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GATTTCCACTTGGTTGTGAAA	0.448											OREG0016481	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	11	26										A	1479749	T	A	1479749	3	1	79	1	0	0	0	0	1	0	0	0	8910	1812	63	5	829	5	LPCAT1	5	1479749	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	592252	1479749	179435511	74	23687										
IRX4	50805	broad.mit.edu	37	chr5	1879903	1879903	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gagcgtgctggtggtctcgcGcgtggcgttcttgcgccgcg	18	12	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:1879903G>A	uc003jcz.2	-	4	570	c.451C>T	c.(451-453)CGC>TGC	p.R151C	IRX4_uc011cmf.1_Missense_Mutation_p.R12C	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	151	Homeobox; TALE-type.				heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		GTGGTCTCGCGCGTGGCGTTC	0.637													0	0	0	0.010504	0	21	38										A	1879903	G	A	1879903	3	1	79	1	0	0	0	0	1	0	0	0	7846	1087	38	2	1116	2	IRX4	5	1879903	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	400154	1879903	179035357	75	23688										
ROPN1L	83853	broad.mit.edu	37	chr5	10461368	10461368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agggcgggcccgctcgcatcCccttcaagacgttttcctac	10	16	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:10461368C>T	uc003jex.3	+	4	761	c.490C>T	c.(490-492)CCC>TCC	p.P164S		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	164					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CGCTCGCATCCCCTTCAAGAC	0.567													0	0	0	0.00499	0	18	105										T	10461368	C	T	10461368	3	4	79	1	0	0	0	0	1	0	0	0	13525	623	22	2	504	2	ROPN1L	5	10461368	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	8581465	10461368	170453892	76	23689										
LMBRD2	92255	broad.mit.edu	37	chr5	36143342	36143342	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gataccaagcaagcagtgttCcaataatcacaagtctatgc	7	10	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:36143342C>G	uc003jkb.1	-	2	525	c.110G>C	c.(109-111)GGA>GCA	p.G37A		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	37	Helical; (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGCAGTGTTCCAATAATCAC	0.363													0	0	0	0.004007	0	16	44										G	36143342	C	G	36143342	3	3	79	1	0	0	0	0	1	0	0	0	8843	855	30	1	2045	1	LMBRD2	5	36143342	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	25681974	36143342	144771918	77	23690										
C5orf42	65250	broad.mit.edu	37	chr5	37195984	37195984	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgctctaatggaaacttcatCaagcttgtggtctccagctg	9	10	4	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:37195984C>T	uc011cpa.1	-	21	4018	c.3787G>A	c.(3787-3789)GAT>AAT	p.D1263N	C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.D338N|C5orf42_uc011cpb.1_Missense_Mutation_p.D144N	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1263										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GAAACTTCATCAAGCTTGTGG	0.378													0	0	0	0.006214	0	10	70										T	37195984	C	T	37195984	3	4	79	1	0	0	0	0	1	0	0	0	2301	826	29	1	5934	1	C5orf42	5	37195984	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1052642	37195984	143719276	78	23691										
EMB	133418	broad.mit.edu	37	chr5	49695706	49695706	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aacttacattttttctatgcCtggggacattattttctata	5	7	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:49695706C>T	uc003jom.2	-	8	1202	c.953G>A	c.(952-954)AGG>AAG	p.R318K	EMB_uc010ivq.2_Missense_Mutation_p.R112K|EMB_uc003jol.2_Missense_Mutation_p.R249K|EMB_uc011cpy.1_Missense_Mutation_p.R268K|EMB_uc010ivr.2_Missense_Mutation_p.R264K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	318	Cytoplasmic (Potential).					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTTTCTATGCCTGGGGACATT	0.269													0	0	0	0.001984	0	7	44										T	49695706	C	T	49695706	3	4	79	1	0	0	0	0	1	0	0	0	5085	681	24	2	38	2	EMB	5	49695706	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	12499722	49695706	131219554	79	23692										
RNF180	285671	broad.mit.edu	37	chr5	63509826	63509826	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gatgcgctacaagagcttttCatagaaaatcacatagtttg	8	7	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:63509826C>A	uc003jti.2	+	4	783	c.673C>A	c.(673-675)CAT>AAT	p.H225N	RNF180_uc003jth.3_Missense_Mutation_p.H225N|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	225	Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		AAGAGCTTTTCATAGAAAATC	0.388													1	0	1.08312e-15	0.009535	1.21013e-15	31	46										A	63509826	C	A	63509826	3	1	79	1	0	0	0	0	1	0	0	0	13464	826	29	3	683	3	RNF180	5	63509826	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	13814120	63509826	117405434	80	23693										
MAN2A1	4124	broad.mit.edu	37	chr5	109152978	109152978	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcagctgtttttgcaggtacCttgtggtctataatccttta	9	8	1	0	rs142458296		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:109152978C>T	uc003kou.1	+	13	2911	c.1948C>T	c.(1948-1950)CTT>TTT	p.L650F		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	650	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TTGCAGGTACCTTGTGGTCTA	0.318													0	0	0	0.016723	0	11	81										T	109152978	C	T	109152978	3	4	79	1	0	0	0	0	1	0	0	0	9214	681	24	2	1998	2	MAN2A1	5	109152978	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	45643152	109152978	71762282	81	23694										
PCDHA6	56142	broad.mit.edu	37	chr5	140208233	140208233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gctagatgtgaaaataaacaGtgatgacaataaacaaattg	8	4	0	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140208233G>A	uc003lho.2	+	1	584	c.557G>A	c.(556-558)AGT>AAT	p.S186N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.S186N|PCDHA6_uc011dab.1_Missense_Mutation_p.S186N	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	186	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAATAAACAGTGATGACAAT	0.443													0	0	0	0.012213	0	34	56										A	140208233	G	A	140208233	3	1	79	1	0	0	0	0	1	0	0	0	11528	1029	36	2	559	2	PCDHA6	5	140208233	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	31055255	140208233	40707027	82	23695										
PCDHA12	56137	broad.mit.edu	37	chr5	140256681	140256681	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgagcgcgcgcgacgccggcGtgccgcctctgggcagcaac	16	16	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140256681G>T	uc003lic.2	+	1	1751	c.1624G>T	c.(1624-1626)GTG>TTG	p.V542L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.V542L	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	542	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACGCCGGCGTGCCGCCTCT	0.701													1	0	2.24893e-16	0.009718	2.52086e-16	43	79										T	140256681	G	T	140256681	3	4	79	1	0	0	0	0	1	0	0	0	11522	1145	40	4	1626	4	PCDHA12	5	140256681	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	48448	140256681	40658579	83	23696										
PCDHA13	56136	broad.mit.edu	37	chr5	140263756	140263756	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctggcgagatcagcacgacgCgccctctggacgaggtggac	15	13	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140263756C>T	uc003lif.2	+	1	1903	c.1903C>T	c.(1903-1905)CGC>TGC	p.R635C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.R635C|PCDHA13_uc003lid.2_Missense_Mutation_p.R635C	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCACGACGCGCCCTCTGGA	0.677													0	0	0	0.00623	0	42	50										T	140263756	C	T	140263756	3	4	79	1	0	0	0	0	1	0	0	0	11523	768	27	2	1905	2	PCDHA13	5	140263756	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	7075	140263756	40651504	84	23697										
PCDHB12	56124	broad.mit.edu	37	chr5	140589944	140589944	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccaacgcccaggtcaactacTcgctgctgccgtcccaggac	9	18	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140589944T>A	uc003liz.2	+	1	1654	c.1465T>A	c.(1465-1467)TCG>ACG	p.S489T	PCDHB12_uc011dak.1_Missense_Mutation_p.S152T	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	489	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCAACTACTCGCTGCTGCC	0.657													0	0	0	0.00499	0	16	102										A	140589944	T	A	140589944	3	1	79	1	0	0	0	0	1	0	0	0	11537	1551	54	5	1467	5	PCDHB12	5	140589944	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	326188	140589944	40325316	85	23698										
KIF4B	285643	broad.mit.edu	37	chr5	154396083	154396083	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	accaaacttgaaaacagcctGagacagagcaaggccagctg	10	11	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:154396083G>T	uc010jih.1	+	1	2824	c.2664G>T	c.(2662-2664)CTG>CTT	p.L888L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	888	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAAACAGCCTGAGACAGAGCA	0.438													1	0	4.35082e-09	0.010504	4.69286e-09	20	34										T	154396083	G	T	154396083	2	4	79	1	0	0	0	0	0	0	0	1	8304	1277	45	3		3	KIF4B	5	154396083	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	13806139	154396083	26519177	86	23699										
ODZ2	57451	broad.mit.edu	37	chr5	167674760	167674760	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gacgatggctatctgtgccaGagagggtctgacatcttcga	13	9	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:167674760G>C	uc010jjd.2	+	27	6789	c.6789G>C	c.(6787-6789)CAG>CAC	p.Q2263H	ODZ2_uc003lzr.3_Missense_Mutation_p.Q2033H|ODZ2_uc003lzt.3_Missense_Mutation_p.Q1636H|ODZ2_uc010jje.2_Missense_Mutation_p.Q1527H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ATCTGTGCCAGAGAGGGTCTG	0.542													0	0	0	0.010729	0	12	58										C	167674760	G	C	167674760	3	2	79	1	0	0	0	0	1	0	0	0	10835	933	33	1	6895	1	ODZ2	5	167674760	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	13278677	167674760	13240500	87	23700										
GRK6	2870	broad.mit.edu	37	chr5	176863486	176863486	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctctttaagaagctgaacttCaagcggctgggagctggcat	12	9	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:176863486C>T	uc011dfz.1	+	13	1519	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	GRK6_uc003mgp.2_Silent_p.F453F|GRK6_uc003mgq.2_Silent_p.F453F|GRK6_uc003mgs.1_Silent_p.F423F	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	453	AGC-kinase C-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTGAACTTCAAGCGGCTGG	0.672													0	0	0	0.008871	0	20	32										T	176863486	C	T	176863486	2	4	79	1	0	0	0	0	0	0	0	1	6793	825	29	1		1	GRK6	5	176863486	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	9188726	176863486	4051774	88	23701										
RIPK1	8737	broad.mit.edu	37	chr6	3077181	3077181	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tccacagaacccagggactcAtgatcatgaaaacagtgtac	8	11	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:3077181A>G	uc010jni.2	+	2	356	c.124A>G	c.(124-126)ATG>GTG	p.M42V	RIPK1_uc003muv.3_5'UTR|RIPK1_uc003muw.3_Intron|RIPK1_uc011dhs.1_Missense_Mutation_p.M42V|RIPK1_uc003mux.2_Missense_Mutation_p.M42V	NM_003804	NP_003795	Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine	42	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			large_intestine(3)|lung(1)|skin(1)	5	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				CCAGGGACTCATGATCATGAA	0.527													0	0	0	0.006122	0	17	33										G	3077181	A	G	3077181	3	3	79	1	0	0	0	0	1	0	0	0	13380	217	8	5	126	5	RIPK1	6	3077181	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08		3077181	168037886	89	23702										
GCNT2	2651	broad.mit.edu	37	chr6	10626656	10626656	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tctttcttttgcaggccactAtgtacatggtatttgtatct	7	8	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10626656A>G	uc010joo.2	+	5	1576	c.1025A>G	c.(1024-1026)TAT>TGT	p.Y342C	GCNT2_uc010jol.2_Missense_Mutation_p.Y56C|GCNT2_uc010jom.2_RNA|GCNT2_uc010jop.2_RNA|GCNT2_uc003mza.2_RNA|GCNT2_uc003mzc.3_Missense_Mutation_p.Y341C|GCNT2_uc003mzd.2_Missense_Mutation_p.Y340C|GCNT2_uc003mze.2_Missense_Mutation_p.Y342C	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	342	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GCAGGCCACTATGTACATGGT	0.398													0	0	0	0.00499	0	17	167										G	10626656	A	G	10626656	3	3	79	1	0	0	0	0	1	0	0	0	6301	449	16	5	2887	5	GCNT2	6	10626656	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	7549475	10626656	160488411	90	23703										
TMEM14C	51522	broad.mit.edu	37	chr6	10726149	10726149	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cttccctctaggcagcgtgcCgtccctggctgcagggctgc	13	16	1	0	rs146638335		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10726149C>T	uc003mzh.2	+	4	288	c.107C>T	c.(106-108)CCG>CTG	p.P36L	TMEM14C_uc010joq.1_Missense_Mutation_p.P36L|TMEM14C_uc003mzi.2_Missense_Mutation_p.P36L	NM_016462	NP_057546	Q9P0S9	TM14C_HUMAN	transmembrane protein 14C	36	Helical; (Potential).				heme biosynthetic process	integral to membrane|mitochondrial membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.135)	Epithelial(50;0.246)			GGCAGCGTGCCGTCCCTGGCT	0.547													0	0	0	0.013537	0	11	178										T	10726149	C	T	10726149	3	4	79	1	0	0	0	0	1	0	0	0	16062	652	23	2	117	2	TMEM14C	6	10726149	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	99493	10726149	160388918	91	23704										
DEK	7913	broad.mit.edu	37	chr6	18256002	18256002	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcattaagaaattcaagatcCtcttcactagttcactattt	4	9	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:18256002C>G	uc003ncr.1	-	6	726	c.533G>C	c.(532-534)AGG>ACG	p.R178T	DEK_uc011djf.1_Missense_Mutation_p.R144T|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	178	SAP.				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			ATTCAAGATCCTCTTCACTAG	0.333			T	NUP214	AML								0	0	0	0.020292	0	14	231										G	18256002	C	G	18256002	3	3	79	1	0	0	0	0	1	0	0	0	4424	681	24	4	618	4	DEK	6	18256002	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	7529853	18256002	152859065	92	23705										
PGBD1	84547	broad.mit.edu	37	chr6	28269137	28269137	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gacagatttgaattgattttCtcaaacctgcactttgcaga	7	8	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:28269137C>G	uc003nky.2	+	7	1876	c.1506C>G	c.(1504-1506)TTC>TTG	p.F502L	PGBD1_uc003nkz.2_Missense_Mutation_p.F502L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	502					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AATTGATTTTCTCAAACCTGC	0.373													0	0	0	0.01441	0	47	117										G	28269137	C	G	28269137	3	3	79	1	0	0	0	0	1	0	0	0	11780	912	32	1	1528	1	PGBD1	6	28269137	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	10013135	28269137	142845930	93	23706										
PGBD1	84547	broad.mit.edu	37	chr6	28269477	28269477	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acttcgctgatgttcttttaGagagaggtcagtatccctat	9	8	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:28269477G>A	uc003nky.2	+	7	2216	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	PGBD1_uc003nkz.2_Missense_Mutation_p.E616K	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	616					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						TGTTCTTTTAGAGAGAGGTCA	0.418													0	0	0	0.01441	0	50	115										A	28269477	G	A	28269477	3	1	79	1	0	0	0	0	1	0	0	0	11780	943	33	1	1868	1	PGBD1	6	28269477	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	340	28269477	142845590	94	23707										
VPS52	6293	broad.mit.edu	37	chr6	33235699	33235699	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	taagacaggtaaatcttgctCagcgtctccacatattcatc	6	11	4	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:33235699C>G	uc003odm.1	-	9	1086	c.876G>C	c.(874-876)CTG>CTC	p.L292L	VPS52_uc003odn.1_Silent_p.L167L|VPS52_uc003odo.1_Silent_p.L217L|VPS52_uc011dqy.1_Silent_p.L167L|VPS52_uc011dqz.1_Silent_p.L167L	NM_022553	NP_072047	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52	292					protein transport	endosome membrane|Golgi apparatus				ovary(4)|skin(1)	5						AAATCTTGCTCAGCGTCTCCA	0.522													0	0	0	0.008361	0	29	44										G	33235699	C	G	33235699	2	3	79	1	0	0	0	0	0	0	0	1	17211	813	29	1		1	VPS52	6	33235699	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	4966222	33235699	137879368	95	23708										
DST	667	broad.mit.edu	37	chr6	56464869	56464869	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tagaaaaccaaattctacctCttgcttggactgatatttct	5	9	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:56464869C>A	uc003pdf.2	-	39	5363	c.5335G>T	c.(5335-5337)GAG>TAG	p.E1779*	DST_uc003pcz.3_Nonsense_Mutation_p.E1601*|DST_uc011dxj.1_Nonsense_Mutation_p.E1630*|DST_uc011dxk.1_Nonsense_Mutation_p.E1641*|DST_uc003pcy.3_Nonsense_Mutation_p.E1275*|DST_uc010kaa.1_5'Flank	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	3687					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AATTCTACCTCTTGCTTGGAC	0.358													1	0	2.17888e-05	0.006214	2.25107e-05	9	65										A	56464869	C	A	56464869	4	1	79	1	0	0	0	0	0	1	0	0	4783	922	32	3	11928	3	DST	6	56464869	Nonsense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	23229170	56464869	114650198	96	23709										
TMEM200A	114801	broad.mit.edu	37	chr6	130762710	130762710	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cctggggctgccagaagacaGtttgggtccaatacatcctt	11	11	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:130762710G>T	uc003qca.2	+	3	2014	c.1143G>T	c.(1141-1143)CAG>CAT	p.Q381H	TMEM200A_uc010kfh.2_Missense_Mutation_p.Q381H|TMEM200A_uc010kfi.2_Missense_Mutation_p.Q381H|TMEM200A_uc003qcb.2_Missense_Mutation_p.Q381H	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	381	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCAGAAGACAGTTTGGGTCCA	0.522													1	0	2.35188e-11	0.006122	2.58556e-11	19	35										T	130762710	G	T	130762710	3	4	79	1	0	0	0	0	1	0	0	0	16120	1020	36	4	1145	4	TMEM200A	6	130762710	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	74297841	130762710	40352357	97	23710										
KIAA1244	57221	broad.mit.edu	37	chr6	138645190	138645190	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gctgcttccacagcggcacgGagagcttcagcggggaaggc	16	12	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:138645190G>C	uc003qhu.2	+	31	4900	c.4900G>C	c.(4900-4902)GAG>CAG	p.E1634Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1634					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CAGCGGCACGGAGAGCTTCAG	0.652													0	0	0	0.020292	0	14	37										C	138645190	G	C	138645190	3	2	79	1	0	0	0	0	1	0	0	0	8217	1175	41	1	5022	1	KIAA1244	6	138645190	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	7882480	138645190	32469877	98	23711										
GRM1	2911	broad.mit.edu	37	chr6	146673612	146673612	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaggaggtgtggtttgatgaGaaaggagacgctcctggaag	18	4	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:146673612G>C	uc010khw.1	+	5	1883	c.1413G>C	c.(1411-1413)GAG>GAC	p.E471D	GRM1_uc010khv.1_Missense_Mutation_p.E471D|GRM1_uc003qll.2_Missense_Mutation_p.E471D|GRM1_uc011edz.1_Missense_Mutation_p.E471D|GRM1_uc011eea.1_Missense_Mutation_p.E471D	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	471	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGTTTGATGAGAAAGGAGACG	0.493													0	0	0	0.01441	0	54	110										C	146673612	G	C	146673612	3	2	79	1	0	0	0	0	1	0	0	0	6796	933	33	1	1427	1	GRM1	6	146673612	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	8028422	146673612	24441455	99	23712										
TIAM2	26230	broad.mit.edu	37	chr6	155485726	155485726	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcttgtctgtttcctctttcCatgctctggtaagttcctga	7	11	4	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:155485726C>T	uc003qqb.2	+	10	3479	c.2206C>T	c.(2206-2208)CAT>TAT	p.H736Y	TIAM2_uc003qqe.2_Missense_Mutation_p.H736Y|TIAM2_uc010kjj.2_Missense_Mutation_p.H269Y|TIAM2_uc003qqf.2_Missense_Mutation_p.H88Y|TIAM2_uc011efl.1_Missense_Mutation_p.H48Y|TIAM2_uc003qqg.2_Missense_Mutation_p.H48Y	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	736					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TTCCTCTTTCCATGCTCTGGT	0.597													0	0	0	0.016522	0	23	117										T	155485726	C	T	155485726	3	4	79	1	0	0	0	0	1	0	0	0	15888	594	21	2	2224	2	TIAM2	6	155485726	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	8812114	155485726	15629341	100	23713										
TXNDC3	51314	broad.mit.edu	37	chr7	37934072	37934072	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tatttgtttttcttagagcaGatcctgaagatagttaagga	9	4	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:37934072G>C	uc003tfn.2	+	16	1776	c.1404G>C	c.(1402-1404)CAG>CAC	p.Q468H		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	468	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCTTAGAGCAGATCCTGAAGA	0.328									Kartagener_syndrome				0	0	0	0.016723	0	13	40										C	37934072	G	C	37934072	3	2	79	1	0	0	0	0	1	0	0	0	16795	933	33	1	1458	1	TXNDC3	7	37934072	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		37934072	121204591	101	23714										
SEMA3D	223117	broad.mit.edu	37	chr7	84628906	84628906	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacatctgttcgcagtactgGtcgaggctgaagtttgggct	13	9	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:84628906G>A	uc003uic.2	-	17	2224	c.2184C>T	c.(2182-2184)GAC>GAT	p.D728D	SEMA3D_uc010led.2_Silent_p.D728D|SEMA3D_uc003uib.2_Silent_p.D367D	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	728					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CGCAGTACTGGTCGAGGCTGA	0.502													0	0	0	0.004007	0	17	64										A	84628906	G	A	84628906	2	1	79	1	0	0	0	0	0	0	0	1	14027	1252	44	2		2	SEMA3D	7	84628906	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	46694834	84628906	74509757	102	23715										
PON3	5446	broad.mit.edu	37	chr7	94989396	94989396	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gagccattgttggcatacacGgtgctcaccctgggcttctc	11	13	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:94989396G>A	uc003unt.2	-	9	979	c.954C>T	c.(952-954)ACC>ACT	p.T318T	PON1_uc011kih.1_Intron	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	318					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TGGCATACACGGTGCTCACCC	0.443													0	0	0	0.008361	0	30	46										A	94989396	G	A	94989396	2	1	79	1	0	0	0	0	0	0	0	1	12250	1103	39	2		2	PON3	7	94989396	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	10360490	94989396	64149267	103	23716										
TECPR1	25851	broad.mit.edu	37	chr7	97862208	97862208	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtcctttccgtgagctgctgGaagatctgcttcctccaggc	11	13	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:97862208G>A	uc003upg.2	-	12	1954	c.1749C>T	c.(1747-1749)TTC>TTT	p.F583F	TECPR1_uc003uph.1_Silent_p.F513F	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	583						integral to membrane	protein binding			pancreas(1)	1						TGAGCTGCTGGAAGATCTGCT	0.632													0	0	0	0.014758	0	5	21										A	97862208	G	A	97862208	2	1	79	1	0	0	0	0	0	0	0	1	15740	1165	41	1		1	TECPR1	7	97862208	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2872812	97862208	61276455	104	23717										
LAMB1	3912	broad.mit.edu	37	chr7	107601691	107601691	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggctctccacgtcgctatcaGaggaggtgtactgaggcagc	14	11	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:107601691G>A	uc003vew.2	-	17	2404	c.2069C>T	c.(2068-2070)TCT>TTT	p.S690F	LAMB1_uc003vev.2_Missense_Mutation_p.S714F|LAMB1_uc003vex.2_Missense_Mutation_p.S690F	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	690	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCGCTATCAGAGGAGGTGTA	0.547													0	0	0	0.013537	0	11	51										A	107601691	G	A	107601691	3	1	79	1	0	0	0	0	1	0	0	0	8610	942	33	1	3363	1	LAMB1	7	107601691	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	9739483	107601691	51536972	105	23718										
ZC3HC1	51530	broad.mit.edu	37	chr7	129688905	129688905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cactctgctaaagaaggcttCtttgcttgtagattccaatg	8	9	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:129688905C>G	uc003vpi.2	-	2	253	c.226G>C	c.(226-228)GAA>CAA	p.E76Q		NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	76					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					AAGAAGGCTTCTTTGCTTGTA	0.408													0	0	0	0.013726	0	32	61										G	129688905	C	G	129688905	3	3	79	1	0	0	0	0	1	0	0	0	17574	922	32	1	1318	1	ZC3HC1	7	129688905	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	22087214	129688905	29449758	106	23719										
DENND2A	27147	broad.mit.edu	37	chr7	140255469	140255469	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctgaagcatcccaggcggctCacaatgcagtaaacttcagg	10	12	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:140255469C>G	uc010lnj.2	-	10	2149	c.2004G>C	c.(2002-2004)GTG>GTC	p.V668V	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.V668V|DENND2A_uc003vvw.2_Silent_p.V668V|DENND2A_uc003vvx.2_Silent_p.V668V	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	668	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CCAGGCGGCTCACAATGCAGT	0.522													0	0	0	0.012319	0	20	72										G	140255469	C	G	140255469	2	3	79	1	0	0	0	0	0	0	0	1	4429	813	29	1		1	DENND2A	7	140255469	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	10566564	140255469	18883194	107	23720										
C7orf33	202865	broad.mit.edu	37	chr7	148312489	148312489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gatttccagaactgacagcaGttaagaattttgcagaatct	8	7	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:148312489G>A	uc003wew.2	+	3	891	c.530G>A	c.(529-531)AGT>AAT	p.S177N		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	177										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACTGACAGCAGTTAAGAATTT	0.378													0	0	0	0.008871	0	20	72										A	148312489	G	A	148312489	3	1	79	1	0	0	0	0	1	0	0	0	2388	1029	36	2	540	2	C7orf33	7	148312489	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	8057020	148312489	10826174	108	23721										
KRBA1	84626	broad.mit.edu	37	chr7	149421876	149421876	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cagcctggcaggcagcccctCagtccctcagccactggaga	11	17	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:149421876C>G	uc003wfz.2	+	9	1461	c.1062C>G	c.(1060-1062)CTC>CTG	p.L354L	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.L22L	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	354										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCAGCCCCTCAGTCCCTCAG	0.562													0	0	0	0.009096	0	4	7										G	149421876	C	G	149421876	2	3	79	1	0	0	0	0	0	0	0	1	8439	813	29	1		1	KRBA1	7	149421876	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1109387	149421876	9716787	109	23722										
MLL3	58508	broad.mit.edu	37	chr7	151902229	151902229	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	actgctcggaaatagagcctGaggaatcttttctgatcaca	9	9	3	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:151902229G>C	uc003wla.2	-	25	4142	c.3923C>G	c.(3922-3924)TCA>TGA	p.S1308*	MLL3_uc003wkz.2_Nonsense_Mutation_p.S369*	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1308					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AATAGAGCCTGAGGAATCTTT	0.358			N		medulloblastoma								0	0	0	0.014758	0	5	25										C	151902229	G	C	151902229	4	2	79	1	0	0	0	0	0	1	0	0	9622	1294	45	1	10952	1	MLL3	7	151902229	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2480353	151902229	7236434	110	23723										
DPP6	1804	broad.mit.edu	37	chr7	154659794	154659794	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aatacagggacattgagattGatgattacagtaagtactac	9	5	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:154659794G>T	uc003wlk.2	+	18	1933	c.1804G>T	c.(1804-1806)GAT>TAT	p.D602Y	DPP6_uc003wli.2_Missense_Mutation_p.D538Y|DPP6_uc003wlm.2_Missense_Mutation_p.D540Y|DPP6_uc011kvq.1_Missense_Mutation_p.D495Y	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	602	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CATTGAGATTGATGATTACAG	0.413													1	0	0.00909568	0.009096	0.00917594	4	12										T	154659794	G	T	154659794	3	4	79	1	0	0	0	0	1	0	0	0	4730	1290	45	3	1990	3	DPP6	7	154659794	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2757565	154659794	4478869	111	23724										
DLC1	10395	broad.mit.edu	37	chr8	12957784	12957784	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gatgatcaaccccagctttgAgggcgctttgtgcttgctgt	12	10	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:12957784A>T	uc003wwm.2	-	9	2506	c.2062T>A	c.(2062-2064)TCA>ACA	p.S688T	DLC1_uc003wwk.1_Missense_Mutation_p.S251T|DLC1_uc003wwl.1_Missense_Mutation_p.S285T|DLC1_uc011kxx.1_Missense_Mutation_p.S177T	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	688					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CCCAGCTTTGAGGGCGCTTTG	0.562													0	0	0	0.007413	0	19	28										T	12957784	A	T	12957784	3	4	79	1	0	0	0	0	1	0	0	0	4550	304	11	5	2564	5	DLC1	8	12957784	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08		12957784	133406238	112	23725										
ST18	9705	broad.mit.edu	37	chr8	53126796	53126796	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agagcgagtacgcagcgtttTatcttcagcctctgcatcca	9	12	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:53126796T>C	uc003xqz.2	-	2	178	c.22A>G	c.(22-24)AAA>GAA	p.K8E	ST18_uc011ldq.1_Translation_Start_Site|ST18_uc011ldr.1_Translation_Start_Site|ST18_uc011lds.1_Translation_Start_Site|ST18_uc003xra.2_Missense_Mutation_p.K8E|ST18_uc003xrb.2_Missense_Mutation_p.K8E|ST18_uc010lyb.2_RNA	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	8						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CGCAGCGTTTTATCTTCAGCC	0.428													0	0	0	0.007291	0	29	47										C	53126796	T	C	53126796	3	2	79	1	0	0	0	0	1	0	0	0	15211	1763	61	5	3201	5	ST18	8	53126796	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	40169012	53126796	93237226	113	23726										
RPS20	6224	broad.mit.edu	37	chr8	56986683	56986683	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	attcggtgaattgccacctcCggctccacgggtgtttttcc	10	13	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:56986683C>T	uc003xsn.2	-	2	237	c.39G>A	c.(37-39)CCG>CCA	p.P13P	RPS20_uc003xsm.2_Silent_p.P13P|SNORD54_uc003xso.1_5'Flank|RPS20_uc011lea.1_5'Flank	NM_001023	NP_001014	P60866	RS20_HUMAN	ribosomal protein S20 isoform 2	13					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			TTGCCACCTCCGGCTCCACGG	0.463													0	0	0	0.010729	0	11	98										T	56986683	C	T	56986683	2	4	79	1	0	0	0	0	0	0	0	1	13632	639	23	2		2	RPS20	8	56986683	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3859887	56986683	89377339	114	23727										
PENK	5179	broad.mit.edu	37	chr8	57354059	57354059	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agttgggggcttctctttaaGcctctcatgaagcccccata	9	12	2	1	rs145346210		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:57354059G>A	uc003xsz.2	-	2	657	c.576C>T	c.(574-576)GGC>GGT	p.G192G	PENK_uc003xta.3_Silent_p.G192G	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	192					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTCTCTTTAAGCCTCTCATGA	0.527													0	0	0	0.01441	0	60	78										A	57354059	G	A	57354059	2	1	79	1	0	0	0	0	0	0	0	1	11727	958	34	2		2	PENK	8	57354059	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	367376	57354059	89009963	115	23728										
PREX2	80243	broad.mit.edu	37	chr8	69005891	69005891	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttgagagtgctcaagaagacCttcaaaaatctcactccaag	7	10	3	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:69005891C>T	uc003xxv.1	+	21	2329	c.2302C>T	c.(2302-2304)CTT>TTT	p.L768F	PREX2_uc003xxu.1_Missense_Mutation_p.L768F|PREX2_uc011lez.1_Missense_Mutation_p.L703F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	768					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.L768I(1)		skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TCAAGAAGACCTTCAAAAATC	0.408													0	0	0	0.00499	0	18	141										T	69005891	C	T	69005891	3	4	79	1	0	0	0	0	1	0	0	0	12477	681	24	2	2384	2	PREX2	8	69005891	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	11651832	69005891	77358131	116	23729										
EYA1	2138	broad.mit.edu	37	chr8	72211939	72211939	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cctgtatatattcctgatgaTgttgtaaaactgctacctaa	6	8	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:72211939T>A	uc003xys.3	-	7	860	c.573A>T	c.(571-573)ACA>ACT	p.T191T	EYA1_uc003xyr.3_Silent_p.T186T|EYA1_uc003xyt.3_Silent_p.T158T|EYA1_uc010lzf.2_Silent_p.T118T|EYA1_uc003xyu.2_Silent_p.T191T|EYA1_uc011lfe.1_Silent_p.T185T|EYA1_uc003xyv.2_Silent_p.T69T	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	191					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TTCCTGATGATGTTGTAAAAC	0.318													0	0	0	0.020292	0	13	91										A	72211939	T	A	72211939	2	1	79	1	0	0	0	0	0	0	0	1	5328	1451	51	5		5	EYA1	8	72211939	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	3206048	72211939	74152083	117	23730										
JPH1	56704	broad.mit.edu	37	chr8	75156998	75156998	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggagggtgctggggggcgttCagcttcacgtagtagccgtg	19	8	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:75156998C>T	uc003yae.2	-	4	1711	c.1671G>A	c.(1669-1671)CTG>CTA	p.L557L	JPH1_uc003yaf.2_Silent_p.L557L|JPH1_uc003yag.1_Silent_p.L421L	NM_020647	NP_065698	Q9HDC5	JPH1_HUMAN	junctophilin 1	557	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				ovary(1)	1	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GGGGGGCGTTCAGCTTCACGT	0.602													0	0	0	0.006122	0	18	97										T	75156998	C	T	75156998	2	4	79	1	0	0	0	0	0	0	0	1	7960	813	29	1		1	JPH1	8	75156998	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2945059	75156998	71207024	118	23731										
MATN2	4147	broad.mit.edu	37	chr8	98943551	98943551	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ataatgatcgtgacagatggGagacctcaggactccgtggc	13	9	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:98943551G>C	uc003yic.2	+	3	744	c.513G>C	c.(511-513)GGG>GGC	p.G171G	MATN2_uc003yib.1_Silent_p.G171G|MATN2_uc010mbh.1_Silent_p.G171G|MATN2_uc003yid.2_Silent_p.G171G|MATN2_uc003yie.1_Silent_p.G171G|MATN2_uc010mbi.1_Silent_p.G45G	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	171	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGACAGATGGGAGACCTCAGG	0.582													0	0	0	0.006214	0	7	31										C	98943551	G	C	98943551	2	2	79	1	0	0	0	0	0	0	0	1	9334	1161	41	1		1	MATN2	8	98943551	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	23786553	98943551	47420471	119	23732										
RGS22	26166	broad.mit.edu	37	chr8	101074892	101074892	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttcattccactgtgatccatCtaacagtttaaattttgata	4	8	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:101074892C>G	uc003yjb.1	-	9	1636	c.1441G>C	c.(1441-1443)GAT>CAT	p.D481H	RGS22_uc003yja.1_Missense_Mutation_p.D300H|RGS22_uc003yjc.1_Missense_Mutation_p.D469H|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	481					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTGATCCATCTAACAGTTTA	0.308													0	0	0	0.001168	0	5	115										G	101074892	C	G	101074892	3	3	79	1	0	0	0	0	1	0	0	0	13305	913	32	1	2429	1	RGS22	8	101074892	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2131341	101074892	45289130	120	23733										
RGS22	26166	broad.mit.edu	37	chr8	101074973	101074973	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	atagcattttttcatcttctCaagatgtctgaaataaaaca	4	7	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:101074973C>T	uc003yjb.1	-	9	1555	c.1360G>A	c.(1360-1362)GAG>AAG	p.E454K	RGS22_uc003yja.1_Missense_Mutation_p.E273K|RGS22_uc003yjc.1_Missense_Mutation_p.E442K|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	454					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTCATCTTCTCAAGATGTCTG	0.313													0	0	0	0.014758	0	5	92										T	101074973	C	T	101074973	3	4	79	1	0	0	0	0	1	0	0	0	13305	835	29	1	2510	1	RGS22	8	101074973	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	81	101074973	45289049	121	23734										
LRP12	29967	broad.mit.edu	37	chr8	105511547	105511547	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcttatttaaaaacacacctGaaaaatatgccagtctgaaa	4	8	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:105511547G>A	uc003yma.2	-	4	568	c.473C>T	c.(472-474)TCA>TTA	p.S158L	LRP12_uc003ymb.2_Missense_Mutation_p.S139L	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	158	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAACACACCTGAAAAATATGC	0.353													0	0	0	0.004482	0	8	123										A	105511547	G	A	105511547	3	1	79	1	0	0	0	0	1	0	0	0	8954	1294	45	1	2122	1	LRP12	8	105511547	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	4436574	105511547	40852475	122	23735										
COL22A1	169044	broad.mit.edu	37	chr8	139691860	139691860	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttgcatagatcttcactgacCttaacacattgccctcccag	5	14	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:139691860C>T	uc003yvd.2	-	40	3519	c.3072G>A	c.(3070-3072)AAG>AAA	p.K1024K	COL22A1_uc011ljo.1_Intron	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1024	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTCACTGACCTTAACACATT	0.348										HNSCC(7;0.00092)			0	0	0	0.013537	0	12	70										T	139691860	C	T	139691860	2	4	79	1	0	0	0	0	0	0	0	1	3681	695	24	2		2	COL22A1	8	139691860	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	34180313	139691860	6672162	123	23736										
SHARPIN	81858	broad.mit.edu	37	chr8	145154091	145154091	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtccatcttctgggggtgctGagggctaggtcctgtggctg	17	9	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:145154091G>A	uc003zba.2	-	7	1424	c.940C>T	c.(940-942)CAG>TAG	p.Q314*	SHARPIN_uc003zbb.2_Intron	NM_030974	NP_112236	Q9H0F6	SHRPN_HUMAN	shank-interacting protein-like 1	314					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			ovary(1)	1	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGGGGTGCTGAGGGCTAGGT	0.672													0	0	0	0.016723	0	13	18										A	145154091	G	A	145154091	4	1	79	1	0	0	0	0	0	1	0	0	14267	1299	45	1	231	1	SHARPIN	8	145154091	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	5462231	145154091	1209931	124	23737										
ZNF7	7553	broad.mit.edu	37	chr8	146068516	146068516	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caaagcttttaatcgtagctCaaggcttacccagcatcaaa	6	11	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:146068516C>G	uc003zeg.3	+	5	2161	c.2024C>G	c.(2023-2025)TCA>TGA	p.S675*	ZNF7_uc010mge.2_Nonsense_Mutation_p.S686*|ZNF7_uc011lln.1_Nonsense_Mutation_p.S579*|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Nonsense_Mutation_p.S579*|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	675	C2H2-type 15.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		AATCGTAGCTCAAGGCTTACC	0.358													0	0	0	0.01441	0	62	83										G	146068516	C	G	146068516	4	3	79	1	0	0	0	0	0	1	0	0	18099	838	29	1	2038	1	ZNF7	8	146068516	Nonsense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	914425	146068516	295506	125	23738										
RFX3	5991	broad.mit.edu	37	chr9	3263030	3263030	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acgagctgcctgggccaggtGattaagcgacgtgtatcttc	13	10	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:3263030G>A	uc003zhr.2	-	14	1822	c.1510C>T	c.(1510-1512)CAC>TAC	p.H504Y	RFX3_uc010mhd.2_Missense_Mutation_p.H504Y|RFX3_uc003zhs.1_Missense_Mutation_p.H504Y	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	504					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TGGGCCAGGTGATTAAGCGAC	0.493													0	0	0	0.00623	0	42	38										A	3263030	G	A	3263030	3	1	79	1	0	0	0	0	1	0	0	0	13264	1290	45	1	915	1	RFX3	9	3263030	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		3263030	137950401	126	23739										
GLIS3	169792	broad.mit.edu	37	chr9	4118290	4118290	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aggccgccgtgctccagctgTtgcatgcgctcgtgctccag	13	15	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:4118290T>C	uc003zhw.1	-	3	917	c.723A>G	c.(721-723)CAA>CAG	p.Q241Q	GLIS3_uc003zhx.1_Silent_p.Q396Q|GLIS3_uc003zic.1_Silent_p.Q396Q|GLIS3_uc003zie.1_Silent_p.Q396Q|GLIS3_uc010mhh.1_Silent_p.Q271Q|GLIS3_uc003zid.1_Silent_p.Q174Q|GLIS3_uc010mhi.1_Silent_p.Q203Q|GLIS3_uc003zif.1_Silent_p.Q174Q|GLIS3_uc003zig.1_Silent_p.Q240Q|GLIS3_uc003zih.1_Silent_p.Q174Q|GLIS3_uc003zhy.1_Silent_p.Q174Q|GLIS3_uc003zhz.1_Silent_p.Q174Q|GLIS3_uc003zib.1_Silent_p.Q240Q|GLIS3_uc010mhg.1_Silent_p.Q174Q	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	241					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCTCCAGCTGTTGCATGCGCT	0.731													0	0	0	0.004672	0	3	1										C	4118290	T	C	4118290	2	2	79	1	0	0	0	0	0	0	0	1	6447	1722	60	5		5	GLIS3	9	4118290	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	855260	4118290	137095141	127	23740										
CNTNAP3	79937	broad.mit.edu	37	chr9	39109271	39109271	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctccttttgggaaaggactaTtgtgtcactagtcctaaaga	9	8	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:39109271T>C	uc004abi.2	-	15	2490	c.2251A>G	c.(2251-2253)ATA>GTA	p.I751V	CNTNAP3_uc004abj.2_Missense_Mutation_p.I750V|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Missense_Mutation_p.I751V	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	751	Fibrinogen C-terminal.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGGACTATTGTGTCACTA	0.433													0	0	0	0.010729	0	11	8										C	39109271	T	C	39109271	3	2	79	1	0	0	0	0	1	0	0	0	3648	1493	52	5	1655	5	CNTNAP3	9	39109271	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	34990981	39109271	102104160	128	23741										
PRUNE2	158471	broad.mit.edu	37	chr9	79441572	79441572	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagttaggaaatttttcttcCaggatagaaagaatttcctc	7	6	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:79441572C>G	uc010mpk.2	-	5	709	c.585G>C	c.(583-585)CTG>CTC	p.L195L	PRUNE2_uc004akn.2_Silent_p.L195L	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	195					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ATTTTTCTTCCAGGATAGAAA	0.443													0	0	0	0.003163	0	16	88										G	79441572	C	G	79441572	2	3	79	1	0	0	0	0	0	0	0	1	12641	581	21	4		4	PRUNE2	9	79441572	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	40332301	79441572	61771859	129	23742										
OGN	4969	broad.mit.edu	37	chr9	95152326	95152326	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aatttcctgtaaaatcgagtCttcttaagttagctagaggg	9	6	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:95152326C>G	uc004asa.2	-	5	675	c.440G>C	c.(439-441)AGA>ACA	p.R147T	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|OGN_uc004asb.2_Missense_Mutation_p.R147T|OGN_uc011ltx.1_Missense_Mutation_p.R165T	NM_014057	NP_054776	P20774	MIME_HUMAN	osteoglycin preproprotein	147	LRR 2.					extracellular space|proteinaceous extracellular matrix	growth factor activity				0						AAAATCGAGTCTTCTTAAGTT	0.294													0	0	0	0.020292	0	13	33										G	95152326	C	G	95152326	3	3	79	1	0	0	0	0	1	0	0	0	10846	913	32	1	468	1	OGN	9	95152326	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	15710754	95152326	46061105	130	23743										
BICD2	23299	broad.mit.edu	37	chr9	95481333	95481333	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtagagattggccagctcctCactgaaggtcaccagctcat	10	12	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:95481333C>T	uc004aso.1	-	5	1651	c.1594G>A	c.(1594-1596)GAG>AAG	p.E532K	BICD2_uc004asp.1_Missense_Mutation_p.E532K	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	532	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						GCCAGCTCCTCACTGAAGGTC	0.632													0	0	0	0.008361	0	28	28										T	95481333	C	T	95481333	3	4	79	1	0	0	0	0	1	0	0	0	1429	835	29	1	995	1	BICD2	9	95481333	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	329007	95481333	45732098	131	23744										
LPPR1	54886	broad.mit.edu	37	chr9	104048468	104048468	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggagaaaacaattctgaccgGagaatgctgttacctgaacc	10	9	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:104048468G>C	uc004bbb.2	+	4	734	c.335G>C	c.(334-336)GGA>GCA	p.G112A	LPPR1_uc011lvi.1_Missense_Mutation_p.G88A|LPPR1_uc004bbc.2_Missense_Mutation_p.G112A|LPPR1_uc010mtc.2_Missense_Mutation_p.G96A	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	112						integral to membrane	catalytic activity				0						ATTCTGACCGGAGAATGCTGT	0.373													0	0	0	0.020292	0	15	53										C	104048468	G	C	104048468	3	2	79	1	0	0	0	0	1	0	0	0	8924	1174	41	1	345	1	LPPR1	9	104048468	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	8567135	104048468	37164963	132	23745										
RGS3	5998	broad.mit.edu	37	chr9	116346235	116346235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agctactggggacccacctgCggcccccaggccagccttcg	12	18	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:116346235C>T	uc004bhq.2	+	21	2752	c.2543C>T	c.(2542-2544)GCG>GTG	p.A848V	RGS3_uc004bhs.2_Missense_Mutation_p.A738V|RGS3_uc004bht.2_Missense_Mutation_p.A567V|RGS3_uc010muy.2_Intron|RGS3_uc004bhv.2_Missense_Mutation_p.A169V|RGS3_uc010muz.1_Missense_Mutation_p.A187V|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.A158V|RGS3_uc004bhx.2_Missense_Mutation_p.A169V|RGS3_uc004bhy.1_Missense_Mutation_p.A158V|RGS3_uc004bhz.2_Missense_Mutation_p.A190V	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	848					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						GACCCACCTGCGGCCCCCAGG	0.617													0	0	0	0.006999	0	41	49										T	116346235	C	T	116346235	3	4	79	1	0	0	0	0	1	0	0	0	13306	768	27	2	2874	2	RGS3	9	116346235	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	12297767	116346235	24867196	133	23746										
DDX31	64794	broad.mit.edu	37	chr9	135523856	135523856	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caccaaccaccgcagccgacTaaaatgaatgttctttgtgg	8	12	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:135523856T>A	uc004cbq.1	-	10	1290	c.1138A>T	c.(1138-1140)AGT>TGT	p.S380C	DDX31_uc010mzu.1_Missense_Mutation_p.S380C|DDX31_uc004cbr.1_Missense_Mutation_p.S380C	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	380	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CGCAGCCGACTAAAATGAATG	0.433													0	0	0	0.00623	0	37	112										A	135523856	T	A	135523856	3	1	79	1	0	0	0	0	1	0	0	0	4356	1522	53	5	1468	5	DDX31	9	135523856	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	19177621	135523856	5689575	134	23747										
CUBN	8029	broad.mit.edu	37	chr10	16990556	16990556	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acgaatctcagcgtcagggcGctgctgaaggatgtgatagg	15	8	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:16990556G>A	uc001ioo.2	-	35	5182	c.5130C>T	c.(5128-5130)AGC>AGT	p.S1710S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1710	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCGTCAGGGCGCTGCTGAAGG	0.512													0	0	0	0.020292	0	15	25										A	16990556	G	A	16990556	2	1	79	1	0	0	0	0	0	0	0	1	4051	1078	38	2		2	CUBN	10	16990556	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		16990556	118544191	135	23748										
ZNF33B	7582	broad.mit.edu	37	chr10	43088096	43088096	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttctcctatgtgtgttctctGatgtacaatgagatttgact	8	7	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:43088096G>A	uc001jaf.1	-	5	2417	c.2302C>T	c.(2302-2304)CAG>TAG	p.Q768*	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Nonsense_Mutation_p.Q656*|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	768	C2H2-type 16.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGTGTTCTCTGATGTACAATG	0.398													0	0	0	0.021523	0	26	175										A	43088096	G	A	43088096	4	1	79	1	0	0	0	0	0	1	0	0	17852	1299	45	1	38	1	ZNF33B	10	43088096	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	26097540	43088096	92446651	136	23749										
CSTF2T	23283	broad.mit.edu	37	chr10	53457995	53457995	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggtttccatcgcacaggtctCcattcctctcctctccatta	5	16	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:53457995C>G	uc001jjp.2	-	1	1361	c.1315G>C	c.(1315-1317)GAG>CAG	p.E439Q	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	439	9 X 5 AA tandem repeats of M-E-T-R-[AG].|Gly-rich.|1-5; approximate.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GCACAGGTCTCCATTCCTCTC	0.537													0	0	0	0.007413	0	19	66										G	53457995	C	G	53457995	3	3	79	1	0	0	0	0	1	0	0	0	3985	864	30	1	539	1	CSTF2T	10	53457995	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	10369899	53457995	82076752	137	23750										
FAM13C	220965	broad.mit.edu	37	chr10	61028376	61028376	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	attttccgcttgaggctctgGatgtgcttggtgagctgggt	15	7	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:61028376G>A	uc001jkn.2	-	9	1013	c.879C>T	c.(877-879)ATC>ATT	p.I293I	FAM13C_uc001jko.2_Silent_p.I293I|FAM13C_uc010qid.1_Silent_p.I210I|FAM13C_uc010qie.1_Silent_p.I210I|FAM13C_uc010qif.1_Silent_p.I315I|FAM13C_uc001jkp.2_Silent_p.I210I	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	293										ovary(2)	2						TGAGGCTCTGGATGTGCTTGG	0.498													0	0	0	0.008291	0	11	24										A	61028376	G	A	61028376	2	1	79	1	0	0	0	0	0	0	0	1	5454	1164	41	1		1	FAM13C	10	61028376	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	7570381	61028376	74506371	138	23751										
PBLD	64081	broad.mit.edu	37	chr10	70048284	70048284	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caacccacggtgcaaaatatCttgagtaaaagtcaaatgct	7	9	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:70048284C>G	uc001jns.1	-	8	850	c.647G>C	c.(646-648)AGA>ACA	p.R216T	PBLD_uc001jnr.1_Missense_Mutation_p.R183T|PBLD_uc001jnt.1_Missense_Mutation_p.R216T|PBLD_uc001jnu.1_Missense_Mutation_p.R216T|PBLD_uc001jnv.1_3'UTR	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	216					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TGCAAAATATCTTGAGTAAAA	0.468													0	0	0	0.003163	0	16	50										G	70048284	C	G	70048284	3	3	79	1	0	0	0	0	1	0	0	0	11489	913	32	1	320	1	PBLD	10	70048284	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	9019908	70048284	65486463	139	23752										
ZMIZ1	57178	broad.mit.edu	37	chr10	81063832	81063832	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacgaccctcaacggggaggAtggggtggagcagacggcca	17	11	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:81063832A>C	uc001kaf.2	+	19	2758	c.2186A>C	c.(2185-2187)GAT>GCT	p.D729A	ZMIZ1_uc001kag.2_Missense_Mutation_p.D605A|ZMIZ1_uc010qlq.1_5'Flank	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	729	SP-RING-type.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AACGGGGAGGATGGGGTGGAG	0.617													0	0	0	0.006214	0	10	36										C	81063832	A	C	81063832	3	2	79	1	0	0	0	0	1	0	0	0	17693	333	12	5	2244	5	ZMIZ1	10	81063832	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	11015548	81063832	54470915	140	23753										
CDHR1	92211	broad.mit.edu	37	chr10	85973956	85973956	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggccatcactgtcctcatctCcaccgccaccttctggcgca	7	19	4	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:85973956C>G	uc001kcv.2	+	17	2159	c.2159C>G	c.(2158-2160)TCC>TGC	p.S720C	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Missense_Mutation_p.S424C|CDHR1_uc001kcx.2_Missense_Mutation_p.S34C	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	720	Helical; (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						GTCCTCATCTCCACCGCCACC	0.637													0	0	0	0.006122	0	18	59										G	85973956	C	G	85973956	3	3	79	1	0	0	0	0	1	0	0	0	3118	855	30	1	2225	1	CDHR1	10	85973956	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	4910124	85973956	49560791	141	23754										
IFIT3	3437	broad.mit.edu	37	chr10	91099693	91099693	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	caaggattaattcataagcaGaatggagatctgctgcaagc	10	7	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:91099693G>A	uc001kgf.2	+	2	1510	c.1281G>A	c.(1279-1281)CAG>CAA	p.Q427Q	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Silent_p.Q427Q	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	427	TPR 7.				type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						TTCATAAGCAGAATGGAGATC	0.433													0	0	0	0.00308	0	8	51										A	91099693	G	A	91099693	2	1	79	1	0	0	0	0	0	0	0	1	7524	933	33	1		1	IFIT3	10	91099693	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	5125737	91099693	44435054	142	23755										
C10orf76	79591	broad.mit.edu	37	chr10	103649229	103649229	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	taggactcaattttggggttAaagtggttgatgatggctct	13	4	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:103649229A>G	uc009xwy.1	-	24	1902	c.1800T>C	c.(1798-1800)TTT>TTC	p.F600F	C10orf76_uc009xwx.1_RNA	NM_024541	NP_078817	Q5T2E6	CJ076_HUMAN	hypothetical protein LOC79591	600						integral to membrane					0		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTTTGGGGTTAAAGTGGTTGA	0.428													0	0	0	0.01441	0	51	180										G	103649229	A	G	103649229	2	3	79	1	0	0	0	0	0	0	0	1	1616	359	13	5		5	C10orf76	10	103649229	Silent	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	12549536	103649229	31885518	143	23756										
PSD	5662	broad.mit.edu	37	chr10	104174879	104174879	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcacctcaggggcaccgtgtCcaggtctgtctcggagtact	13	13	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:104174879C>T	uc001kvg.1	-	4	1392	c.865G>A	c.(865-867)GAC>AAC	p.D289N	PSD_uc001kvh.1_5'UTR|PSD_uc009xxd.1_Missense_Mutation_p.D289N	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	289					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGCACCGTGTCCAGGTCTGTC	0.672													0	0	0	0.00308	0	8	43										T	104174879	C	T	104174879	3	4	79	1	0	0	0	0	1	0	0	0	12646	855	30	1	2265	1	PSD	10	104174879	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	525650	104174879	31359868	144	23757										
TRUB1	142940	broad.mit.edu	37	chr10	116732026	116732026	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aaattccagccaccatttttCacattaggtaagatggagaa	7	8	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:116732026C>T	uc001lcd.2	+	6	790	c.729C>T	c.(727-729)TTC>TTT	p.F243F	TRUB1_uc010qsl.1_Silent_p.F145F	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	243					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		CACCATTTTTCACATTAGGTA	0.358													0	0	0	0.009535	0	30	52										T	116732026	C	T	116732026	2	4	79	1	0	0	0	0	0	0	0	1	16599	825	29	1		1	TRUB1	10	116732026	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	12557147	116732026	18802721	145	23758										
PNLIP	5406	broad.mit.edu	37	chr10	118306905	118306905	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tatattgccttggtctccaaAagatgtcaacacccgcttcc	6	13	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:118306905A>G	uc001lcm.2	+	3	189	c.146A>G	c.(145-147)AAA>AGA	p.K49R		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	49					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGGTCTCCAAAAGATGTCAAC	0.398													0	0	0	0.008291	0	11	65										G	118306905	A	G	118306905	3	3	79	1	0	0	0	0	1	0	0	0	12149	14	1	5	152	5	PNLIP	10	118306905	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	1574879	118306905	17227842	146	23759										
WDR11	55717	broad.mit.edu	37	chr10	122626260	122626260	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcaagtctgcagtttgtaatCgaaattcacggaacaggtaa	9	7	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:122626260C>A	uc010qtf.1	+	8	1412	c.1174C>A	c.(1174-1176)CGA>AGA	p.R392R	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	392	WD 3.					integral to membrane					0						AGTTTGTAATCGAAATTCACG	0.393													1	0	2.81731e-10	0.010818	3.06774e-10	31	56										A	122626260	C	A	122626260	2	1	79	1	0	0	0	0	0	0	0	1	17270	876	31	3		3	WDR11	10	122626260	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	4319355	122626260	12908487	147	23760										
C10orf88	80007	broad.mit.edu	37	chr10	124708192	124708192	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgacacctaaccatatccatCaactgctgagctccaggaga	7	13	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:124708192C>T	uc001lgw.2	-	4	846	c.621G>A	c.(619-621)TTG>TTA	p.L207L	C10orf88_uc001lgx.2_Silent_p.L109L	NM_024942	NP_079218	Q9H8K7	CJ088_HUMAN	hypothetical protein LOC80007	207											0		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		CCATATCCATCAACTGCTGAG	0.413													0	0	0	0.006214	0	10	42										T	124708192	C	T	124708192	2	4	79	1	0	0	0	0	0	0	0	1	1622	825	29	1		1	C10orf88	10	124708192	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2081932	124708192	10826555	148	23761										
MGMT	4255	broad.mit.edu	37	chr10	131565235	131565235	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agggagcgggagctacctcgGgctccccgcctgctggccga	16	15	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:131565235G>T	uc001lkh.2	+	5	717	c.691G>T	c.(691-693)GGC>TGC	p.G231C		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	200										ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		AGCTACCTCGGGCTCCCCGCC	0.637								Direct_reversal_of_damage					1	0	5.18039e-06	0.00308	5.4173e-06	8	17										T	131565235	G	T	131565235	3	4	79	1	0	0	0	0	1	0	0	0	9557	1232	43	4	709	4	MGMT	10	131565235	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	6857043	131565235	3969512	149	23762										
TRIM68	55128	broad.mit.edu	37	chr11	4623543	4623543	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggccagagctgctgctacctCtgcccccagctgccgatgtg	12	16	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:4623543C>T	uc001lzf.1	-	4	860	c.622G>A	c.(622-624)GAG>AAG	p.E208K	TRIM68_uc001lzg.1_5'UTR|TRIM68_uc010qyj.1_RNA|TRIM68_uc009yek.1_Missense_Mutation_p.E208K	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	208	Potential.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCTGCTACCTCTGCCCCCAGC	0.537													0	0	0	0.00499	0	18	24										T	4623543	C	T	4623543	3	4	79	1	0	0	0	0	1	0	0	0	16538	922	32	1	851	1	TRIM68	11	4623543	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		4623543	130382973	150	23763										
OR51G1	79324	broad.mit.edu	37	chr11	4944672	4944672	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aatgatgcgctggcgaatttGcttggtcttgatgctgtaga	13	6	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:4944672G>T	uc010qyr.1	-	1	898	c.898C>A	c.(898-900)CAA>AAA	p.Q300K		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCGAATTTGCTTGGTCTTG	0.423													1	0	0.000308642	0.003163	0.000316013	16	42										T	4944672	G	T	4944672	3	4	79	1	0	0	0	0	1	0	0	0	11098	1328	46	4	69	4	OR51G1	11	4944672	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	321129	4944672	130061844	151	23764										
OR51I2	390064	broad.mit.edu	37	chr11	5475260	5475261	+	Frame_Shift_Ins	INS	-	-	C													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tctcactcctactgcctgcaINScccagacatgatgaggcttg							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:5475260_5475261insC	uc010qzf.1	+	1	542_543	c.542_543insC	c.(541-543)CACfs	p.H181fs	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACTGCCTGCACCCAGACATGA	0.46																		34	41	---	---								C	5475261	-	C	5475260	7	5	79	1	0	1	1	0	0	0	0	0	11101	159	6	0	544	0	OR51I2	11	5475260	Frame_Shift_Ins	INS	-	TCGA-FD-A3SJ-01A-12D-A22Z-08	530588	5475260	129531256	152	23765										
MICAL2	9645	broad.mit.edu	37	chr11	12231097	12231097	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	accattctctgtcggagtttGagtttgacgtcatcattggt	10	8	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:12231097G>C	uc001mjz.2	+	6	931	c.643G>C	c.(643-645)GAG>CAG	p.E215Q	MICAL2_uc010rch.1_Missense_Mutation_p.E215Q|MICAL2_uc001mka.2_Missense_Mutation_p.E215Q|MICAL2_uc010rci.1_Missense_Mutation_p.E215Q|MICAL2_uc001mkb.2_Missense_Mutation_p.E215Q|MICAL2_uc001mkc.2_Missense_Mutation_p.E215Q|MICAL2_uc001mkd.2_Missense_Mutation_p.E44Q	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	215						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GTCGGAGTTTGAGTTTGACGT	0.532													0	0	0	0.00632	0	29	33										C	12231097	G	C	12231097	3	2	79	1	0	0	0	0	1	0	0	0	9570	1291	45	1	657	1	MICAL2	11	12231097	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	6755837	12231097	122775419	153	23766										
LGR4	55366	broad.mit.edu	37	chr11	27405924	27405924	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccatcaaaacagtgttgactCaggcttctaattttattgtt	6	8	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:27405924C>G	uc001mrj.3	-	6	1133	c.648G>C	c.(646-648)CTG>CTC	p.L216L	LGR4_uc001mrk.3_Silent_p.L192L	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	216	LRR 7.|Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						AGTGTTGACTCAGGCTTCTAA	0.323													0	0	0	0.010818	0	32	42										G	27405924	C	G	27405924	2	3	79	1	0	0	0	0	0	0	0	1	8756	813	29	1		1	LGR4	11	27405924	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	15174827	27405924	107600592	154	23767										
KCNA4	3739	broad.mit.edu	37	chr11	30032651	30032651	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggcttcatgtccccatagccCacagttgtcatggtcaccac	8	15	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:30032651C>G	uc001msk.2	-	2	2727	c.1575G>C	c.(1573-1575)GTG>GTC	p.V525V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	525	Selectivity filter (By similarity).					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCCCATAGCCCACAGTTGTCA	0.517													0	0	0	0.016723	0	14	40										G	30032651	C	G	30032651	2	3	79	1	0	0	0	0	0	0	0	1	8005	581	21	4		4	KCNA4	11	30032651	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2626727	30032651	104973865	155	23768										
TRAF6	7189	broad.mit.edu	37	chr11	36512195	36512195	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tggcgtgccaagtgattcctCtgcatctaaaaatcaagcac	8	11	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:36512195C>T	uc001mwr.1	-	8	1102	c.762G>A	c.(760-762)CAG>CAA	p.Q254Q	TRAF6_uc001mws.1_Silent_p.Q254Q	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	254	Interaction with TAX1BP1.|TRAF-type 2.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				AGTGATTCCTCTGCATCTAAA	0.473													0	0	0	0.00632	0	28	57										T	36512195	C	T	36512195	2	4	79	1	0	0	0	0	0	0	0	1	16442	912	32	1		1	TRAF6	11	36512195	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	6479544	36512195	98494321	156	23769										
OR5D18	219438	broad.mit.edu	37	chr11	55587908	55587908	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgtgcccaactccaaaaactCcaggcacacagtcaaagtgg	8	13	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:55587908C>G	uc010rin.1	+	1	803	c.803C>G	c.(802-804)TCC>TGC	p.S268C		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCCAAAAACTCCAGGCACACA	0.507													0	0	0	0.008361	0	32	59										G	55587908	C	G	55587908	3	3	79	1	0	0	0	0	1	0	0	0	11157	855	30	1	805	1	OR5D18	11	55587908	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	19075713	55587908	79418608	157	23770										
OR10AG1	282770	broad.mit.edu	37	chr11	55735793	55735793	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttgctaagaaaaaaatacatGggagtctggagagcggggtg	15	4	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:55735793G>A	uc010rit.1	-	1	147	c.147C>T	c.(145-147)CCC>CCT	p.P49P		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	49	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					AAAAATACATGGGAGTCTGGA	0.333													0	0	0	0.01441	0	48	54										A	55735793	G	A	55735793	2	1	79	1	0	0	0	0	0	0	0	1	10897	1335	47	2		2	OR10AG1	11	55735793	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	147885	55735793	79270723	158	23771										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57069342	57069342	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcagccccttggtgcccaacGacatccgtgtccggcggctc	11	17	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57069342G>A	uc001njr.2	-	8	5222	c.4910C>T	c.(4909-4911)TCG>TTG	p.S1637L	TNKS1BP1_uc001njp.2_Missense_Mutation_p.S209L|TNKS1BP1_uc001njq.2_Missense_Mutation_p.S210L|TNKS1BP1_uc001njs.2_Missense_Mutation_p.S1637L	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1637	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GGTGCCCAACGACATCCGTGT	0.582													0	0	0	0.009096	0	4	56										A	57069342	G	A	57069342	3	1	79	1	0	0	0	0	1	0	0	0	16317	1059	37	1	291	1	TNKS1BP1	11	57069342	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1333549	57069342	77937174	159	23772										
PRG3	10394	broad.mit.edu	37	chr11	57147185	57147185	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgcctgaatcacctcctccgTcagagccaagtctctctcct	6	17	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57147185T>A	uc001njv.1	-	3	267	c.157A>T	c.(157-159)ACG>TCG	p.T53S		NM_006093	NP_006084	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3 precursor	53					basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding				0						ACCTCCTCCGTCAGAGCCAAG	0.562													0	0	0	0.004656	0	26	82										A	57147185	T	A	57147185	3	1	79	1	0	0	0	0	1	0	0	0	12480	1667	58	5	536	5	PRG3	11	57147185	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	77843	57147185	77859331	160	23773										
OR10Q1	219960	broad.mit.edu	37	chr11	57995510	57995510	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gacaaaggtgtagaccaacgCgatttggctgtcctcatcct	10	11	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57995510C>T	uc010rkd.1	-	1	838	c.838G>A	c.(838-840)GCG>ACG	p.A280T		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				TAGACCAACGCGATTTGGCTG	0.547													0	0	0	0.014323	0	23	118										T	57995510	C	T	57995510	3	4	79	1	0	0	0	0	1	0	0	0	10916	768	27	2	125	2	OR10Q1	11	57995510	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	848325	57995510	77011006	161	23774										
PLAC1L	219990	broad.mit.edu	37	chr11	59807984	59807984	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcttgatttggaccggtgctGagaacctccatggtaaataa	10	8	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:59807984G>A	uc001nol.2	+	1	237	c.52G>A	c.(52-54)GAG>AAG	p.E18K		NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor	18						extracellular region				ovary(2)|skin(1)	3						GACCGGTGCTGAGAACCTCCA	0.458													0	0	0	0.012213	0	31	79										A	59807984	G	A	59807984	3	1	79	1	0	0	0	0	1	0	0	0	12013	1291	45	1	54	1	PLAC1L	11	59807984	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1812474	59807984	75198532	162	23775										
TMEM132A	54972	broad.mit.edu	37	chr11	60695278	60695278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctggcagcctgccctgtgccCggctccatgccacacaccct	9	20	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:60695278C>T	uc001nqj.2	+	3	674	c.481C>T	c.(481-483)CGG>TGG	p.R161W	TMEM132A_uc001nqi.2_Missense_Mutation_p.R161W|TMEM132A_uc001nqk.2_Missense_Mutation_p.R174W|TMEM132A_uc001nql.1_Missense_Mutation_p.R174W	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	161	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						GCCCTGTGCCCGGCTCCATGC	0.652													0	0	0	0.021523	0	26	45										T	60695278	C	T	60695278	3	4	79	1	0	0	0	0	1	0	0	0	16042	643	23	2	491	2	TMEM132A	11	60695278	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	887294	60695278	74311238	163	23776										
NPAS4	266743	broad.mit.edu	37	chr11	66190264	66190264	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacctggagcctactgggcaGgaaatcccgtgttcacagct	11	13	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:66190264G>T	uc001ohx.1	+	4	726	c.550G>T	c.(550-552)GGA>TGA	p.G184*	NPAS4_uc010rpc.1_Missense_Mutation_p.Q10H	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	184					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CTACTGGGCAGGAAATCCCGT	0.622													1	0	2.98393e-07	0.016522	3.1984e-07	25	97										T	66190264	G	T	66190264	4	4	79	1	0	0	0	0	0	1	0	0	10565	1001	35	4	564	4	NPAS4	11	66190264	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	5494986	66190264	68816252	164	23777										
NPAS4	266743	broad.mit.edu	37	chr11	66191516	66191516	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cctgaactgagtgttgtctcTgcatcagaagagcttccccg	10	12	2	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:66191516T>C	uc001ohx.1	+	7	1331	c.1155T>C	c.(1153-1155)TCT>TCC	p.S385S	NPAS4_uc010rpc.1_Silent_p.S175S	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	385					transcription, DNA-dependent		DNA binding|signal transducer activity				0						GTGTTGTCTCTGCATCAGAAG	0.562													0	0	0	0.007291	0	31	193										C	66191516	T	C	66191516	2	2	79	1	0	0	0	0	0	0	0	1	10565	1567	55	5		5	NPAS4	11	66191516	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	1252	66191516	68815000	165	23778										
CABP4	57010	broad.mit.edu	37	chr11	67222934	67222934	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gggggcagcagggcccaaatCtggccattggccgtcagaag	16	11	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:67222934C>G	uc001olo.2	+	1	117	c.40C>G	c.(40-42)CTG>GTG	p.L14V	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	14					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GGGCCCAAATCTGGCCATTGG	0.632													0	0	0	0.001168	0	5	5										G	67222934	C	G	67222934	3	3	79	1	0	0	0	0	1	0	0	0	2533	912	32	1	42	1	CABP4	11	67222934	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1031418	67222934	67783582	166	23779										
UNC93B1	81622	broad.mit.edu	37	chr11	67766749	67766749	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	catcctgctccttgtagtggGagtactcatggtacttctgc	10	11	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:67766749G>C	uc001omw.1	-	5	661	c.581C>G	c.(580-582)TCC>TGC	p.S194C		NM_030930	NP_112192	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1	194					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome					0						CTTGTAGTGGGAGTACTCATG	0.612													0	0	0	0.004007	0	17	17										C	67766749	G	C	67766749	3	2	79	1	0	0	0	0	1	0	0	0	16994	1174	41	1	1239	1	UNC93B1	11	67766749	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	543815	67766749	67239767	167	23780										
SAPS3	55291	broad.mit.edu	37	chr11	68331787	68331788	+	Frame_Shift_Ins	INS	-	-	A													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagatttgaaggccatatagINSagatctgcccaccaggcatg							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:68331787_68331788insA	uc001onw.2	+	9	1129_1130	c.862_863insA	c.(862-864)GAGfs	p.E288fs	SAPS3_uc001onv.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc001ony.3_Frame_Shift_Ins_p.E288fs|SAPS3_uc001onx.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc009ysh.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc001onu.2_Frame_Shift_Ins_p.E288fs|SAPS3_uc010rqc.1_Intron|SAPS3_uc010rqd.1_5'UTR	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	288					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			AGGCCATATAGAGATCTGCCCA	0.376																		55	94	---	---								A	68331788	-	A	68331787	7	5	79	1	0	1	1	0	0	0	0	0	13838	943	33	0	888	0	SAPS3	11	68331787	Frame_Shift_Ins	INS	-	TCGA-FD-A3SJ-01A-12D-A22Z-08	565038	68331787	66674729	168	23781										
ARHGEF17	9828	broad.mit.edu	37	chr11	73066945	73066945	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aggagaagcaggcgctgtctGacctcatgatcaagcctgtg	13	10	3	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:73066945G>A	uc001otu.2	+	5	3631	c.3610G>A	c.(3610-3612)GAC>AAC	p.D1204N		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1204	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGCGCTGTCTGACCTCATGAT	0.567													0	0	0	0.010818	0	28	99										A	73066945	G	A	73066945	3	1	79	1	0	0	0	0	1	0	0	0	900	1290	45	1	3628	1	ARHGEF17	11	73066945	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	4735158	73066945	61939571	169	23782										
ARHGEF17	9828	broad.mit.edu	37	chr11	73067780	73067780	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcccctctgcggcggttcctGagacaggagatggtcattga	14	11	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:73067780G>A	uc001otu.2	+	7	3888	c.3867G>A	c.(3865-3867)CTG>CTA	p.L1289L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1289					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						GGCGGTTCCTGAGACAGGAGA	0.552													0	0	0	0.004482	0	7	35										A	73067780	G	A	73067780	2	1	79	1	0	0	0	0	0	0	0	1	900	1277	45	1		1	ARHGEF17	11	73067780	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	835	73067780	61938736	170	23783										
UVRAG	7405	broad.mit.edu	37	chr11	75852128	75852128	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aacaaggagaagccctctccGggcaccgggccacagtcaat	11	14	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:75852128G>A	uc001oxc.2	+	15	2012	c.1771G>A	c.(1771-1773)GGG>AGG	p.G591R	UVRAG_uc010rrw.1_Missense_Mutation_p.G490R|UVRAG_uc001oxd.2_Missense_Mutation_p.G219R|UVRAG_uc010rrx.1_Missense_Mutation_p.G219R|UVRAG_uc010rry.1_Missense_Mutation_p.G147R	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	591					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						AGCCCTCTCCGGGCACCGGGC	0.577													0	0	0	0.004482	0	9	28										A	75852128	G	A	75852128	3	1	79	1	0	0	0	0	1	0	0	0	17105	1116	39	2	1829	2	UVRAG	11	75852128	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2784348	75852128	59154388	171	23784										
EED	8726	broad.mit.edu	37	chr11	85977208	85977209	+	Missense_Mutation	DNP	GA	GA	CT													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aggatcaattcaaagagaatGatgaatgcaattaaggaatc							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:85977208_85977209GA>CT	uc001pbp.2	+	8	1267_1268	c.810_811GA>CT	c.(808-813)ATGATG>ATCTTG	p.270_271MM>IL	EED_uc010rtm.1_Missense_Mutation_p.270_271MM>IL|EED_uc001pbq.2_Missense_Mutation_p.270_271MM>IL|EED_uc001pbr.2_Missense_Mutation_p.270_271MM>IL|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	270_271	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				CAAAGAGAATGATGAATGCAAT	0.302													0	0	0	0.004672	0	13	85										CT	85977209	GA	CT	85977208	3	2	79	1	0	0	0	0	1	0	0	0	4922	1290	45	1	840	1	EED	11	85977208	Missense_Mutation	DNP	GA	TCGA-FD-A3SJ-01A-12D-A22Z-08	10125080	85977208	49029308	172	23785										
TRPC6	7225	broad.mit.edu	37	chr11	101347251	101347251	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agtccagatttctttacattCagcccatatcatgcctgcat	5	12	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:101347251C>T	uc001pgk.3	-	6	1950	c.1525G>A	c.(1525-1527)GAA>AAA	p.E509K	TRPC6_uc009ywy.2_Missense_Mutation_p.E393K|TRPC6_uc009ywz.1_Missense_Mutation_p.E454K	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	509	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TCTTTACATTCAGCCCATATC	0.378													0	0	0	0.021523	0	25	27										T	101347251	C	T	101347251	3	4	79	1	0	0	0	0	1	0	0	0	16580	835	29	1	1302	1	TRPC6	11	101347251	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	15370043	101347251	33659265	173	23786										
OR8A1	390275	broad.mit.edu	37	chr11	124440753	124440753	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgcagctcccaccttgcagcCgtgggaatgttctatggatc	11	12	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:124440753C>T	uc010san.1	+	1	789	c.789C>T	c.(787-789)GCC>GCT	p.A263A		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	263	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		ACCTTGCAGCCGTGGGAATGT	0.507													0	0	0	0.007291	0	28	31										T	124440753	C	T	124440753	2	4	79	1	0	0	0	0	0	0	0	1	11225	639	23	2		2	OR8A1	11	124440753	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	23093502	124440753	10565763	174	23787										
RPUSD4	84881	broad.mit.edu	37	chr11	126081382	126081382	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cttgttcccgtttctgggctCggagcttctccgctaatctc	9	14	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:126081382C>T	uc001qde.2	-	1	206	c.152G>A	c.(151-153)CGA>CAA	p.R51Q	FAM118B_uc001qdf.2_5'Flank|FAM118B_uc009zca.2_5'Flank|FAM118B_uc001qdg.2_5'Flank|RPUSD4_uc009zbz.2_Missense_Mutation_p.R51Q|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	51	Potential.				pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		TTTCTGGGCTCGGAGCTTCTC	0.567													0	0	0	0.01441	0	61	80										T	126081382	C	T	126081382	3	4	79	1	0	0	0	0	1	0	0	0	13669	884	31	1	1009	1	RPUSD4	11	126081382	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1640629	126081382	8925134	175	23788										
ATF7IP	55729	broad.mit.edu	37	chr12	14589126	14589126	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gatatatggaagaagaatatGaggcagaatttcaagtaaag	11	2	1	4			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:14589126G>A	uc001rbw.2	+	4	1890	c.1732G>A	c.(1732-1734)GAG>AAG	p.E578K	ATF7IP_uc010shs.1_Missense_Mutation_p.E577K|ATF7IP_uc001rbu.2_Missense_Mutation_p.E578K|ATF7IP_uc001rbv.1_Missense_Mutation_p.E577K|ATF7IP_uc001rbx.2_Missense_Mutation_p.E577K|ATF7IP_uc010sht.1_Missense_Mutation_p.E578K|ATF7IP_uc001rby.3_Missense_Mutation_p.E578K|ATF7IP_uc001rca.2_Missense_Mutation_p.E578K	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	578	Interaction with SETDB1.|Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						AGAAGAATATGAGGCAGAATT	0.323													0	0	0	0.012213	0	31	51										A	14589126	G	A	14589126	3	1	79	1	0	0	0	0	1	0	0	0	1087	1291	45	1	1742	1	ATF7IP	12	14589126	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		14589126	119262769	176	23789										
SLCO1B3	28234	broad.mit.edu	37	chr12	21229431	21229431	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tggggctctgattgatacaaCgtgtatgaagtggtccacca	12	8	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:21229431C>T	uc010sil.1	+	15	2041	c.1976C>T	c.(1975-1977)ACG>ATG	p.T659M	LST-3TM12_uc010sim.1_Missense_Mutation_p.T598M|LST-3TM12_uc010sin.1_Missense_Mutation_p.T551M			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ATTGATACAACGTGTATGAAG	0.363													0	0	0	0.007291	0	29	84										T	21229431	C	T	21229431	3	4	79	1	0	0	0	0	1	0	0	0	14724	536	19	2		2	SLCO1B3	12	21229431	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	6640305	21229431	112622464	177	23790										
KIAA0528	9847	broad.mit.edu	37	chr12	22646159	22646159	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gttgttattatcatttaccaGatgctagttgattcactgta	7	6	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:22646159G>C	uc001rfq.2	-	11	1488	c.1260C>G	c.(1258-1260)ATC>ATG	p.I420M	KIAA0528_uc010sir.1_Missense_Mutation_p.I235M|KIAA0528_uc010sis.1_Missense_Mutation_p.I420M|KIAA0528_uc010sit.1_Missense_Mutation_p.I422M|KIAA0528_uc010siu.1_Missense_Mutation_p.I420M|KIAA0528_uc001rfr.2_Missense_Mutation_p.I411M|KIAA0528_uc009ziy.1_Missense_Mutation_p.I422M	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	420							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TCATTTACCAGATGCTAGTTG	0.363													0	0	0	0.004007	0	17	92										C	22646159	G	C	22646159	3	2	79	1	0	0	0	0	1	0	0	0	8182	932	33	1	1802	1	KIAA0528	12	22646159	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1416728	22646159	111205736	178	23791										
PPFIBP1	8496	broad.mit.edu	37	chr12	27787986	27787986	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aaacagatgagaaagaaggcTtgagatgccagatcccagat	11	7	0	6			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:27787986T>A	uc001ric.1	+	4	585	c.208T>A	c.(208-210)TTG>ATG	p.L70M	PPFIBP1_uc001rhy.1_Missense_Mutation_p.L70M|PPFIBP1_uc001rhz.1_Missense_Mutation_p.L70M|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.L70M|PPFIBP1_uc001ria.2_Missense_Mutation_p.L70M|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	70					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					GAAAGAAGGCTTGAGATGCCA	0.458													0	0	0	0.020292	0	13	64										A	27787986	T	A	27787986	3	1	79	1	0	0	0	0	1	0	0	0	12313	1606	56	5	214	5	PPFIBP1	12	27787986	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	5141827	27787986	106063909	179	23792										
CNTN1	1272	broad.mit.edu	37	chr12	41421762	41421762	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcaaatgaatctacagtgacGggatataaggtatatacaaa	8	5	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:41421762G>T	uc001rmm.1	+	22	2927	c.2814G>T	c.(2812-2814)ACG>ACT	p.T938T	CNTN1_uc001rmn.1_Silent_p.T927T	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	938	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CTACAGTGACGGGATATAAGG	0.348													1	0	1.5739e-10	0.004007	1.71926e-10	16	37										T	41421762	G	T	41421762	2	4	79	1	0	0	0	0	0	0	0	1	3640	1103	39	4		4	CNTN1	12	41421762	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	13633776	41421762	92430133	180	23793										
ARID2	196528	broad.mit.edu	37	chr12	46244661	46244661	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agcagcctattcaacaaccaCagcagccaacccaacaaagc	5	16	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:46244661C>G	uc001ros.1	+	15	2755	c.2755C>G	c.(2755-2757)CAG>GAG	p.Q919E	ARID2_uc001ror.2_Missense_Mutation_p.Q919E|ARID2_uc009zkg.1_Missense_Mutation_p.Q375E|ARID2_uc009zkh.1_Missense_Mutation_p.Q546E|ARID2_uc001rou.1_Missense_Mutation_p.Q253E	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	919	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCAACAACCACAGCAGCCAAC	0.473													0	0	0	0.006122	0	17	123										G	46244661	C	G	46244661	3	3	79	1	0	0	0	0	1	0	0	0	915	479	17	4	2813	4	ARID2	12	46244661	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	4822899	46244661	87607234	181	23794										
CCNT1	904	broad.mit.edu	37	chr12	49087819	49087819	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	attcttctgcatgcttcgcgCggtattctttcagtgacact	8	11	4	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:49087819C>A	uc001rse.1	-	9	1501	c.1178G>T	c.(1177-1179)CGC>CTC	p.R393L	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.R108L	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	393	Potential.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						ATGCTTCGCGCGGTATTCTTT	0.448													1	0	3.99451e-17	0.009535	4.49218e-17	32	160										A	49087819	C	A	49087819	3	1	79	1	0	0	0	0	1	0	0	0	2934	768	27	4	1006	4	CCNT1	12	49087819	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2843158	49087819	84764076	182	23795										
KRT5	3852	broad.mit.edu	37	chr12	52910468	52910468	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cggtaagtggcgatctccacGtccagggccagcttggtgtt	14	11	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:52910468G>A	uc001san.2	-	7	1555	c.1392C>T	c.(1390-1392)GAC>GAT	p.D464D	KRT5_uc009zmh.2_Silent_p.D464D	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	464	Rod.|Coil 2.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		CGATCTCCACGTCCAGGGCCA	0.602													0	0	0	0.007291	0	30	105										A	52910468	G	A	52910468	2	1	79	1	0	0	0	0	0	0	0	1	8479	1136	40	2		2	KRT5	12	52910468	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	3822649	52910468	80941427	183	23796										
ERBB3	2065	broad.mit.edu	37	chr12	56477672	56477672	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcacgggacacaatgccgacCtctccttcctgcaggttagt	9	14	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:56477672C>T	uc001sjh.2	+	2	413	c.220C>T	c.(220-222)CTC>TTC	p.L74F	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.L15F|ERBB3_uc001sjg.2_Missense_Mutation_p.L74F	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	74	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAATGCCGACCTCTCCTTCCT	0.537													0	0	0	0.005443	0	27	71										T	56477672	C	T	56477672	3	4	79	1	0	0	0	0	1	0	0	0	5208	681	24	2	226	2	ERBB3	12	56477672	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3567204	56477672	77374223	184	23797										
LRP1	4035	broad.mit.edu	37	chr12	57548325	57548325	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cgctgtgacatggatgggcaGaaccgcaccaagctcgtcga	13	12	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:57548325G>T	uc001snd.2	+	8	1534	c.1068G>T	c.(1066-1068)CAG>CAT	p.Q356H	LRP1_uc001snc.1_Missense_Mutation_p.Q356H	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	356	LDL-receptor class B 2.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGATGGGCAGAACCGCACCA	0.527													1	0	2.17888e-05	0.006214	2.25107e-05	10	27										T	57548325	G	T	57548325	3	4	79	1	0	0	0	0	1	0	0	0	8951	933	33	3	1098	3	LRP1	12	57548325	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1070653	57548325	76303570	185	23798										
CYP27B1	1594	broad.mit.edu	37	chr12	58158842	58158842	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcagaggcggccccagggccCaggcacaaggtggcgcagcc	17	15	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:58158842C>A	uc001spz.1	-	4	894	c.742G>T	c.(742-744)GGG>TGG	p.G248W	CYP27B1_uc001sqa.1_Missense_Mutation_p.G13W|CYP27B1_uc001sqb.1_Missense_Mutation_p.W128L|CYP27B1_uc001sqc.1_Missense_Mutation_p.W128L	NM_000785	NP_000776	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B,	248					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)	3	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CCCCAGGGCCCAGGCACAAGG	0.622											OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	7.93312e-07	0.020292	8.4505e-07	13	54										A	58158842	C	A	58158842	3	1	79	1	0	0	0	0	1	0	0	0	4159	594	21	4	808	4	CYP27B1	12	58158842	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	610517	58158842	75693053	186	23799										
SLC6A15	55117	broad.mit.edu	37	chr12	85266933	85266933	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgcaaacaccaccaatgttgCcaggacagaagtgaaaaaat	8	9	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:85266933C>A	uc001szv.2	-	7	1535	c.1042G>T	c.(1042-1044)GCA>TCA	p.A348S	SLC6A15_uc010sul.1_Missense_Mutation_p.A241S|SLC6A15_uc001szw.1_Missense_Mutation_p.A56S	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	348	Helical; Name=7; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ACCAATGTTGCCAGGACAGAA	0.393													1	0	0.00307968	0.00308	0.00313451	8	56										A	85266933	C	A	85266933	3	1	79	1	0	0	0	0	1	0	0	0	14678	739	26	4	1174	4	SLC6A15	12	85266933	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	27108091	85266933	48584962	187	23800										
RASSF9	9182	broad.mit.edu	37	chr12	86199049	86199049	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttcctcatactgcaagtctaGattttgctcaacttcactga	5	11	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:86199049G>T	uc001taf.1	-	2	1078	c.739C>A	c.(739-741)CTA>ATA	p.L247I		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	247	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TGCAAGTCTAGATTTTGCTCA	0.403													1	0	1.01871e-10	0.008871	1.11635e-10	19	85										T	86199049	G	T	86199049	3	4	79	1	0	0	0	0	1	0	0	0	13093	933	33	3	572	3	RASSF9	12	86199049	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	932116	86199049	47652846	188	23801										
NTS	4922	broad.mit.edu	37	chr12	86272172	86272172	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gatgactctgctaaatgtttGcagtcttgtaaataatttga	8	5	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:86272172G>T	uc001tag.2	+	3	292	c.185G>T	c.(184-186)TGC>TTC	p.C62F		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	62					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						CTAAATGTTTGCAGTCTTGTA	0.358													1	0	1.50039e-11	0.012319	1.65477e-11	21	107										T	86272172	G	T	86272172	3	4	79	1	0	0	0	0	1	0	0	0	10709	1319	46	4	195	4	NTS	12	86272172	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	73123	86272172	47579723	189	23802										
TCP11L2	255394	broad.mit.edu	37	chr12	106712230	106712230	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	catgccatcaaactgtttgaAgaaatcagagaggcaagttg	10	7	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:106712230A>G	uc001tln.2	+	4	576	c.402A>G	c.(400-402)GAA>GAG	p.E134E	TCP11L2_uc001tll.2_Silent_p.E134E|TCP11L2_uc001tlm.2_Silent_p.E134E	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	134										ovary(3)	3						AACTGTTTGAAGAAATCAGAG	0.328													0	0	0	0.003163	0	15	46										G	106712230	A	G	106712230	2	3	79	1	0	0	0	0	0	0	0	1	15712	69	3	5		5	TCP11L2	12	106712230	Silent	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	20440058	106712230	27139665	190	23803										
ACACB	32	broad.mit.edu	37	chr12	109654448	109654448	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcagcgggatccgcggctatAtgaaaacagtggtgttggat	15	7	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:109654448A>G	uc001tob.2	+	23	3495	c.3376A>G	c.(3376-3378)ATG>GTG	p.M1126V	ACACB_uc001toc.2_Missense_Mutation_p.M1126V	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1126					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CCGCGGCTATATGAAAACAGT	0.473													0	0	0	0.006214	0	10	32										G	109654448	A	G	109654448	3	3	79	1	0	0	0	0	1	0	0	0	107	449	16	5	3462	5	ACACB	12	109654448	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	2942218	109654448	24197447	191	23804										
RASAL1	8437	broad.mit.edu	37	chr12	113554886	113554886	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acccacatttacccagaatcCtcctcggctctgggaaaggg	9	14	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:113554886C>T	uc001tum.1	-	9	1016	c.723G>A	c.(721-723)GAG>GAA	p.E241E	RASAL1_uc010syp.1_Silent_p.E241E|RASAL1_uc001tul.2_Silent_p.E241E|RASAL1_uc001tun.1_Silent_p.E241E|RASAL1_uc010syq.1_Silent_p.E241E|RASAL1_uc001tuo.3_Silent_p.E241E|RASAL1_uc010syr.1_Silent_p.E241E	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	241					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						ACCCAGAATCCTCCTCGGCTC	0.607													0	0	0	0.001984	0	6	24										T	113554886	C	T	113554886	2	4	79	1	0	0	0	0	0	0	0	1	13063	680	24	2		2	RASAL1	12	113554886	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3900438	113554886	20297009	192	23805										
TBX5	6910	broad.mit.edu	37	chr12	114823367	114823367	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttattctcaatctttaattgCgtgatctgaaggaaagagga	9	5	3	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:114823367C>T	uc001tvo.2	-	7	1164	c.669G>A	c.(667-669)ACG>ACA	p.T223T	TBX5_uc001tvp.2_Silent_p.T223T|TBX5_uc001tvq.2_Silent_p.T173T|TBX5_uc010syv.1_Silent_p.T223T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	223	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCTTTAATTGCGTGATCTGAA	0.418													0	0	0	0.014758	0	5	23										T	114823367	C	T	114823367	2	4	79	1	0	0	0	0	0	0	0	1	15658	755	27	2		2	TBX5	12	114823367	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1268481	114823367	19028528	193	23806										
DNAH10	196385	broad.mit.edu	37	chr12	124352470	124352470	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtaacccagttagccaagatGttggatgcgttgctagaagg	13	7	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:124352470G>T	uc001uft.3	+	42	6994	c.6969G>T	c.(6967-6969)ATG>ATT	p.M2323I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2323					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAGCCAAGATGTTGGATGCGT	0.512													1	0	0.00010058	0.013537	0.0001036	11	14										T	124352470	G	T	124352470	3	4	79	1	0	0	0	0	1	0	0	0	4598	1377	48	4	7135	4	DNAH10	12	124352470	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	9529103	124352470	9499425	194	23807										
FAM101A	144347	broad.mit.edu	37	chr12	124798930	124798930	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttccgcagcaccaccatcatCttccccaagcatgccaggag	7	17	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:124798930C>G	uc001ugd.1	+	3	510	c.267C>G	c.(265-267)ATC>ATG	p.I89M	FAM101A_uc001uge.1_Missense_Mutation_p.I89M	NM_181709	NP_859060	Q6ZTI6	F101A_HUMAN	hypothetical protein LOC144347	170											0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CCACCATCATCTTCCCCAAGC	0.687													0	0	0	0.008361	0	28	40										G	124798930	C	G	124798930	3	3	79	1	0	0	0	0	1	0	0	0	5380	903	32	1	273	1	FAM101A	12	124798930	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	446460	124798930	9052965	195	23808										
TMEM132D	121256	broad.mit.edu	37	chr12	130184385	130184385	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agcgatcttcagtggaatttCtggagatggaaacaggaaaa	12	5	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:130184385C>G	uc009zyl.1	-	2	1266	c.938G>C	c.(937-939)AGA>ACA	p.R313T		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	313	Extracellular (Potential).					integral to membrane		p.R313G(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGTGGAATTTCTGGAGATGGA	0.502													0	0	0	0.00308	0	6	39										G	130184385	C	G	130184385	3	3	79	1	0	0	0	0	1	0	0	0	16044	913	32	1	2393	1	TMEM132D	12	130184385	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	5385455	130184385	3667510	196	23809										
N4BP2L2	10443	broad.mit.edu	37	chr13	33018121	33018121	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	actctgagatgggtcctgatCtcccggtgtaagatcactta	10	10	3	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:33018121C>G	uc010abe.1	-	7	575	c.553G>C	c.(553-555)GAT>CAT	p.D185H	N4BP2L2_uc001uug.2_Missense_Mutation_p.D68H|N4BP2L2_uc010abd.1_Missense_Mutation_p.D98H|N4BP2L2_uc001uuh.2_Missense_Mutation_p.D16H|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.D170H	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GGGTCCTGATCTCCCGGTGTA	0.383													0	0	0	0.009096	0	4	9										G	33018121	C	G	33018121	3	3	79	1	0	0	0	0	1	0	0	0	10112	913	32	1	1717	1	N4BP2L2	13	33018121	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		33018121	82151757	197	23810										
KBTBD7	84078	broad.mit.edu	37	chr13	41766515	41766515	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttcctcagtaataaaactctGaccaggttcaaggcaggaag	9	9	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:41766515G>A	uc001uxw.1	-	1	2188	c.1879C>T	c.(1879-1881)CAG>TAG	p.Q627*	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	627							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		ATAAAACTCTGACCAGGTTCA	0.438													0	0	0	0.009535	0	33	74										A	41766515	G	A	41766515	4	1	79	1	0	0	0	0	0	1	0	0	7998	1299	45	1	179	1	KBTBD7	13	41766515	Nonsense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	8748394	41766515	73403363	198	23811										
SLC15A1	6564	broad.mit.edu	37	chr13	99337111	99337111	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagtatagaaccgagccatgAtggcaaaaattacacagacg	9	8	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:99337111A>G	uc001vno.2	-	23	2071	c.1994T>C	c.(1993-1995)ATC>ACC	p.I665T		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	665	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCGAGCCATGATGGCAAAAAT	0.413													0	0	0	0.001984	0	6	45										G	99337111	A	G	99337111	3	3	79	1	0	0	0	0	1	0	0	0	14398	333	12	5	136	5	SLC15A1	13	99337111	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	57570596	99337111	15832767	199	23812										
MYO16	23026	broad.mit.edu	37	chr13	109817341	109817341	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acagaaatgcaaataaccatGgaattcagttatctaattca	5	7	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:109817341G>A	uc001vqt.1	+	33	5317	c.5191G>A	c.(5191-5193)GGA>AGA	p.G1731R	MYO16_uc010agk.1_Missense_Mutation_p.G1753R	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1731					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AAATAACCATGGAATTCAGTT	0.338													0	0	0	0.001168	0	5	69										A	109817341	G	A	109817341	3	1	79	1	0	0	0	0	1	0	0	0	10064	1349	47	2	5317	2	MYO16	13	109817341	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	10480230	109817341	5352537	200	23813										
CDC16	8881	broad.mit.edu	37	chr13	115037904	115037904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgttagagacatctatgtcaGaccacagcacgtgactccag	9	11	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:115037904G>C	uc001vuk.1	+	18	2047	c.1849G>C	c.(1849-1851)GAC>CAC	p.D617H	CDC16_uc001vul.1_Missense_Mutation_p.D617H|CDC16_uc001vum.1_Missense_Mutation_p.D523H|CDC16_uc001vun.1_Missense_Mutation_p.D616H|CDC16_uc001vuo.1_Missense_Mutation_p.D565H	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6	617					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			ATCTATGTCAGACCACAGCAC	0.453													0	0	0	0.005524	0	36	17										C	115037904	G	C	115037904	3	2	79	1	0	0	0	0	1	0	0	0	3058	942	33	1	1919	1	CDC16	13	115037904	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	5220563	115037904	131974	201	23814										
OR4K17	390436	broad.mit.edu	37	chr14	20586060	20586060	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aagcccctacactacatgacCatcatgaacaagaaggtatg	7	11	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:20586060C>T	uc001vwo.1	+	1	495	c.495C>T	c.(493-495)ACC>ACT	p.T165T		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ACTACATGACCATCATGAACA	0.453													0	0	0	0.008291	0	11	95										T	20586060	C	T	20586060	2	4	79	1	0	0	0	0	0	0	0	1	11071	581	21	2		2	OR4K17	14	20586060	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		20586060	86763480	202	23815										
OR11H4	390442	broad.mit.edu	37	chr14	20711554	20711554	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tggctctatcctgtgccccaGctcccataactgaatgtatt	7	13	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:20711554G>T	uc010tld.1	+	1	604	c.604G>T	c.(604-606)GCT>TCT	p.A202S		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	202	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CTGTGCCCCAGCTCCCATAAC	0.433													1	0	2.01871e-26	0.01441	2.28521e-26	66	98										T	20711554	G	T	20711554	3	4	79	1	0	0	0	0	1	0	0	0	10928	971	34	4	606	4	OR11H4	14	20711554	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	125494	20711554	86637986	203	23816										
FUT8	2530	broad.mit.edu	37	chr14	66136117	66136117	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctcagaattggcgctatgctActggtggatgggagactgta	14	7	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:66136117A>G	uc001xin.2	+	7	1951	c.754A>G	c.(754-756)ACT>GCT	p.T252A	FUT8_uc001xio.2_Missense_Mutation_p.T252A|FUT8_uc010tsp.1_Missense_Mutation_p.T89A|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.T252A|FUT8_uc001xiq.2_Missense_Mutation_p.T123A|FUT8_uc001xis.2_5'Flank	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	252	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		GCGCTATGCTACTGGTGGATG	0.502													0	0	0	0.006214	0	10	48										G	66136117	A	G	66136117	3	3	79	1	0	0	0	0	1	0	0	0	6110	391	14	5	871	5	FUT8	14	66136117	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	45424563	66136117	41213423	204	23817										
OR4M2	390538	broad.mit.edu	37	chr15	22368693	22368693	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccttctatttgttcatcctaCcaggaaatatccttatcatt	3	11	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:22368693C>A	uc010tzu.1	+	1	118	c.118C>A	c.(118-120)CCA>ACA	p.P40T	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GTTCATCCTACCAGGAAATAT	0.418													1	0	1.62957e-23	0.00874	1.83863e-23	44	389										A	22368693	C	A	22368693	3	1	79	1	0	0	0	0	1	0	0	0	11076	507	18	4	120	4	OR4M2	15	22368693	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		22368693	80162699	205	23818										
C15orf2	23742	broad.mit.edu	37	chr15	24921968	24921968	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccaaggagcgctgctcctccCagagctgcccgcaacaggcc	11	18	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:24921968C>G	uc001ywo.2	+	1	1428	c.954C>G	c.(952-954)CCC>CCG	p.P318P		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	318	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTGCTCCTCCCAGAGCTGCCC	0.587													0	0	0	0.001168	0	6	50										G	24921968	C	G	24921968	2	3	79	1	0	0	0	0	0	0	0	1	1784	581	21	4		4	C15orf2	15	24921968	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2553275	24921968	77609424	206	23819										
MAPKBP1	23005	broad.mit.edu	37	chr15	42113042	42113042	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cccaccaggcacaggagtccGtggggttcctggacccagct	13	15	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:42113042G>A	uc001zok.3	+	24	2798	c.2512G>A	c.(2512-2514)GTG>ATG	p.V838M	MAPKBP1_uc001zoj.3_Missense_Mutation_p.V832M|MAPKBP1_uc010bcj.2_Missense_Mutation_p.V339M|MAPKBP1_uc010bci.2_Missense_Mutation_p.V832M|MAPKBP1_uc010udb.1_Missense_Mutation_p.V671M|MAPKBP1_uc010bck.2_Missense_Mutation_p.V49M|MAPKBP1_uc010bcl.2_Missense_Mutation_p.V339M	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	838										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ACAGGAGTCCGTGGGGTTCCT	0.488													0	0	0	0.001168	0	6	13										A	42113042	G	A	42113042	3	1	79	1	0	0	0	0	1	0	0	0	9292	1145	40	2	2602	2	MAPKBP1	15	42113042	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	17191074	42113042	60418350	207	23820										
SCAPER	49855	broad.mit.edu	37	chr15	76995205	76995205	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acctaccaggacattgcagaGagaacactgcttctttcttt	7	11	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:76995205G>C	uc002bby.2	-	18	2445	c.2386C>G	c.(2386-2388)CTC>GTC	p.L796V	SCAPER_uc010bkr.2_Missense_Mutation_p.L104V|SCAPER_uc002bbx.2_Missense_Mutation_p.L550V|SCAPER_uc002bbz.1_Missense_Mutation_p.L667V|SCAPER_uc002bca.1_Missense_Mutation_p.L661V|SCAPER_uc002bcb.1_Missense_Mutation_p.L802V	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	795	C2H2-type.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						ACATTGCAGAGAGAACACTGC	0.358													0	0	0	0.00499	0	17	70										C	76995205	G	C	76995205	3	2	79	1	0	0	0	0	1	0	0	0	13878	942	33	1	1872	1	SCAPER	15	76995205	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	34882163	76995205	25536187	208	23821										
ALPK3	57538	broad.mit.edu	37	chr15	85382285	85382285	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	actgtggcttgccaaaatatGagatcactcatcagggcaac	9	10	3	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:85382285G>A	uc002ble.2	+	4	1152	c.985G>A	c.(985-987)GAG>AAG	p.E329K		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	329	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCAAAATATGAGATCACTCA	0.572													0	0	0	0.010729	0	12	10										A	85382285	G	A	85382285	3	1	79	1	0	0	0	0	1	0	0	0	546	1291	45	1	999	1	ALPK3	15	85382285	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	8387080	85382285	17149107	209	23822										
CHD2	1106	broad.mit.edu	37	chr15	93563489	93563489	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacagagattattatgacagGtatgcaaaaggctgtgagac	11	6	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:93563489G>A	uc002bsp.2	+	38	5728	c.5153_splice	c.e38+1	p.R1718_splice	CHD2_uc002bso.1_Silent_p.R1718R	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATTATGACAGGTATGCAAAAG	0.463													0	0	0	0.00499	0	17	26										A	93563489	G	A	93563489	5	1	79	1	0	0	0	0	0	0	1	0	3325	1275	44	2	5304	2	CHD2	15	93563489	Splice_Site	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	8181204	93563489	8967903	210	23823										
PCSK6	5046	broad.mit.edu	37	chr15	101938656	101938656	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cttagccagtcggccgggccCgtccaccgtcttgccgtcgt	12	17	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:101938656C>A	uc002bwy.2	-	8	1263	c.949G>T	c.(949-951)GGG>TGG	p.G317W	PCSK6_uc010bpd.2_Missense_Mutation_p.G187W|PCSK6_uc010bpe.2_Missense_Mutation_p.G317W|PCSK6_uc002bxa.2_Missense_Mutation_p.G317W|PCSK6_uc002bxb.2_Missense_Mutation_p.G317W|PCSK6_uc002bxc.1_Missense_Mutation_p.G317W|PCSK6_uc002bxd.1_Missense_Mutation_p.G317W|PCSK6_uc002bxe.2_Missense_Mutation_p.G317W|PCSK6_uc002bxg.1_Missense_Mutation_p.G317W	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	317	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CGGCCGGGCCCGTCCACCGTC	0.582													1	0	6.94344e-10	0.006122	7.53671e-10	15	111										A	101938656	C	A	101938656	3	1	79	1	0	0	0	0	1	0	0	0	11604	652	23	4	2503	4	PCSK6	15	101938656	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	8375167	101938656	592736	211	23824										
SSTR5	6755	broad.mit.edu	37	chr16	1129228	1129228	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctggtcatgacgctggacggCgtcaaccagttcaccagtgt	12	12	3	1	rs35742768	byFrequency	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:1129228C>T	uc002ckq.2	+	1	448	c.360C>T	c.(358-360)GGC>GGT	p.G120G	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	120	Helical; Name=3; (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCTGGACGGCGTCAACCAGT	0.677													0	0	0	0.014758	0	4	38										T	1129228	C	T	1129228	2	4	79	1	0	0	0	0	0	0	0	1	15200	755	27	2		2	SSTR5	16	1129228	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		1129228	89225525	212	23825										
RPL3L	6123	broad.mit.edu	37	chr16	1996698	1996698	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttcaccagcttcccgtcctcCatgtgcgggcccctgccgat	9	18	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:1996698C>T	uc002cnh.2	-	7	926	c.879G>A	c.(877-879)ATG>ATA	p.M293I		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	293					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						TCCCGTCCTCCATGTGCGGGC	0.652													0	0	0	0.004482	0	9	30										T	1996698	C	T	1996698	3	4	79	1	0	0	0	0	1	0	0	0	13594	594	21	2	360	2	RPL3L	16	1996698	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	867470	1996698	88358055	213	23826										
MEFV	4210	broad.mit.edu	37	chr16	3298929	3298929	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cagaaagctcactgccttctCctccccataggatcgctgct	7	16	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:3298929C>G	uc002cun.1	-	4	1376	c.1336G>C	c.(1336-1338)GAG>CAG	p.E446Q		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	446					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	ACTGCCTTCTCCTCCCCATAG	0.532													0	0	0	0.007413	0	20	128										G	3298929	C	G	3298929	3	3	79	1	0	0	0	0	1	0	0	0	9459	864	30	1	1037	1	MEFV	16	3298929	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1302231	3298929	87055824	214	23827										
ZC3H7A	29066	broad.mit.edu	37	chr16	11850213	11850213	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agccatagttcgtaaaattgCtccatatcttgtactaaaga	6	8	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:11850213C>T	uc002dbk.2	-	20	2640	c.2442G>A	c.(2440-2442)GAG>GAA	p.E814E	ZC3H7A_uc002dbi.2_Silent_p.E2E|ZC3H7A_uc002dbj.2_RNA|ZC3H7A_uc002dbl.2_Silent_p.E814E|ZC3H7A_uc002dbm.1_Silent_p.E724E	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	814						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						CGTAAAATTGCTCCATATCTT	0.338													0	0	0	0.016723	0	14	35										T	11850213	C	T	11850213	2	4	79	1	0	0	0	0	0	0	0	1	17569	796	28	2		2	ZC3H7A	16	11850213	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	8551284	11850213	78504540	215	23828										
ZP2	7783	broad.mit.edu	37	chr16	21211121	21211121	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aaagccttcatgtcaaacctCtgatagtgatcaggatgggt	10	8	4	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:21211121C>T	uc002dii.2	-	15	1773	c.1773G>A	c.(1771-1773)CAG>CAA	p.Q591Q	ZP2_uc010bwn.1_Silent_p.Q621Q	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	591	Extracellular (Potential).|ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		TGTCAAACCTCTGATAGTGAT	0.502													0	0	0	0.014323	0	22	39										T	21211121	C	T	21211121	2	4	79	1	0	0	0	0	0	0	0	1	18213	912	32	1		1	ZP2	16	21211121	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	9360908	21211121	69143632	216	23829										
DPEP2	64174	broad.mit.edu	37	chr16	68021779	68021779	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tccacttgtctgaagacccgCagcaggtttccacgaaggac	10	13	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:68021779C>T	uc010cey.2	-	9	1346	c.1182G>A	c.(1180-1182)CTG>CTA	p.L394L	DPEP2_uc002evd.3_Silent_p.L399L|DPEP2_uc002eve.2_Silent_p.L394L|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	394					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TGAAGACCCGCAGCAGGTTTC	0.567													0	0	0	0.009535	0	30	186										T	68021779	C	T	68021779	2	4	79	1	0	0	0	0	0	0	0	1	4714	697	25	2		2	DPEP2	16	68021779	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	46810658	68021779	22332974	217	23830										
TP53	7157	broad.mit.edu	37	chr17	7577559	7577559	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggttcatgccgcccatgcagGaactgttacacatgtagttg	11	10	1	0	rs28934573		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:7577559G>A	uc002gim.2	-	7	916	c.722C>T	c.(721-723)TCC>TTC	p.S241F	TP53_uc002gig.1_Missense_Mutation_p.S241F|TP53_uc002gih.2_Missense_Mutation_p.S241F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.S109F|TP53_uc010cng.1_Missense_Mutation_p.S109F|TP53_uc002gii.1_Missense_Mutation_p.S109F|TP53_uc010cnh.1_Missense_Mutation_p.S241F|TP53_uc010cni.1_Missense_Mutation_p.S241F|TP53_uc002gij.2_Missense_Mutation_p.S241F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S148F|TP53_uc002gio.2_Missense_Mutation_p.S109F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	241	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		S -> A (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(73)|p.S241C(24)|p.S241fs*6(8)|p.0?(7)|p.S241Y(7)|p.C242fs*5(6)|p.S241A(6)|p.S241del(5)|p.S241T(5)|p.N239_C242delNSSC(3)|p.S241S(3)|p.S241P(3)|p.S241fs*22(2)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_C242insX(1)|p.S241_G245delSCMGG(1)|p.C238fs*21(1)|p.S241fs*7(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.S241fs*23(1)|p.N239_C242del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.013537	0	13	21										A	7577559	G	A	7577559	3	1	79	1	0	0	0	0	1	0	0	0	16378	1174	41	1	568	1	TP53	17	7577559	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08		7577559	73617651	218	23831										
MYH13	8735	broad.mit.edu	37	chr17	10216603	10216603	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttggcttcctgctcctcctcAtactgttcccgcagcaggtc	8	16	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:10216603A>T	uc002gmk.1	-	30	4143	c.4053T>A	c.(4051-4053)TAT>TAA	p.Y1351*		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1351	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GCTCCTCCTCATACTGTTCCC	0.602													0	0	0	0.010504	0	19	80										T	10216603	A	T	10216603	4	4	79	1	0	0	0	0	0	1	0	0	10032	224	8	5	1811	5	MYH13	17	10216603	Nonsense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	2639044	10216603	70978607	219	23832										
AMAC1	146861	broad.mit.edu	37	chr17	33520951	33520951	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agtggcagcgttgccagcggGcaccacctgaaccgcactgt	13	14	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:33520951G>A	uc002hjd.2	-	1	462	c.376C>T	c.(376-378)CCC>TCC	p.P126S		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	126	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		TTGCCAGCGGGCACCACCTGA	0.607													0	0	0	0.01441	0	93	156										A	33520951	G	A	33520951	3	1	79	1	0	0	0	0	1	0	0	0	559	1203	42	2	644	2	AMAC1	17	33520951	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	23304348	33520951	47674259	220	23833										
MYO19	80179	broad.mit.edu	37	chr17	34864917	34864917	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctacctatgaaagtggtccaCgagtcggtgtctgcacagat	11	10	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:34864917C>A	uc010wcy.1	-	15	2207	c.1215G>T	c.(1213-1215)TCG>TCT	p.S405S	MYO19_uc002hmw.2_Silent_p.S405S|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	405	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGTGGTCCACGAGTCGGTGT	0.547													1	0	9.05144e-12	0.016723	1.00474e-11	12	17										A	34864917	C	A	34864917	2	1	79	1	0	0	0	0	0	0	0	1	10067	523	19	4		4	MYO19	17	34864917	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1343966	34864917	46330293	221	23834										
GPATCH8	23131	broad.mit.edu	37	chr17	42476849	42476849	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acttgagtaagaacgccgggAggaacgatgcgaggaatggc	16	7	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:42476849A>T	uc002igw.1	-	8	2660	c.2596T>A	c.(2596-2598)TCC>ACC	p.S866T	GPATCH8_uc002igv.1_Missense_Mutation_p.S788T|GPATCH8_uc010wiz.1_Missense_Mutation_p.S788T	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	866	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GAACGCCGGGAGGAACGATGC	0.537													0	0	0	0.017118	0	35	93										T	42476849	A	T	42476849	3	4	79	1	0	0	0	0	1	0	0	0	6594	304	11	5	1916	5	GPATCH8	17	42476849	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	7611932	42476849	38718361	222	23835										
ICT1	3396	broad.mit.edu	37	chr17	73016618	73016618	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aacaggttaggagagttgatCctcacctctgagagcagccg	12	10	2	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:73016618C>G	uc002jmm.2	+	5	404	c.402C>G	c.(400-402)ATC>ATG	p.I134M		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	134					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					GAGAGTTGATCCTCACCTCTG	0.468													0	0	0	0.008291	0	10	61										G	73016618	C	G	73016618	3	3	79	1	0	0	0	0	1	0	0	0	7488	845	30	1	420	1	ICT1	17	73016618	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	30539769	73016618	8178592	223	23836										
ITGB4	3691	broad.mit.edu	37	chr17	73738530	73738530	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cagagggccttccacgacctCaaggtggcccccggctacta	11	16	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:73738530C>G	uc002jpg.2	+	24	2929	c.2742C>G	c.(2740-2742)CTC>CTG	p.L914L	ITGB4_uc002jph.2_Silent_p.L914L|ITGB4_uc002jpi.3_Silent_p.L914L|ITGB4_uc010dgp.1_Missense_Mutation_p.Q927E|ITGB4_uc002jpj.2_Silent_p.L914L	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	914	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCACGACCTCAAGGTGGCCC	0.657													0	0	0	0.00308	0	8	14										G	73738530	C	G	73738530	2	3	79	1	0	0	0	0	0	0	0	1	7897	813	29	1		1	ITGB4	17	73738530	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	721912	73738530	7456680	224	23837										
GAA	2548	broad.mit.edu	37	chr17	78082619	78082619	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agggcggccggcgctacatgAtgatcgtggtgtgtgccccc	16	12	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78082619A>G	uc002jxo.2	+	9	1500	c.1318A>G	c.(1318-1320)ATG>GTG	p.M440V	GAA_uc002jxp.2_Missense_Mutation_p.M440V|GAA_uc002jxq.2_Missense_Mutation_p.M440V	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	440					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GCGCTACATGATGATCGTGGT	0.642													0	0	0	0.006214	0	7	11										G	78082619	A	G	78082619	3	3	79	1	0	0	0	0	1	0	0	0	6147	333	12	5	1344	5	GAA	17	78082619	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	4344089	78082619	3112591	225	23838										
RNF213	57674	broad.mit.edu	37	chr17	78321834	78321834	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcgtctgtggtgctgcaggtCatagagaggcagggtccccg	17	10	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78321834C>T	uc002jyh.1	+	4	4141	c.3918C>T	c.(3916-3918)GTC>GTT	p.V1306V		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGCTGCAGGTCATAGAGAGGC	0.582													0	0	0	0.01892	0	21	66										T	78321834	C	T	78321834	2	4	79	1	0	0	0	0	0	0	0	1	13477	813	29	1		1	RNF213	17	78321834	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	239215	78321834	2873376	226	23839										
RPTOR	57521	broad.mit.edu	37	chr17	78519560	78519560	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaaaattgaaggctccaaatCcttagctcagagctggagga	11	8	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78519560C>G	uc002jyt.1	+	1	936	c.131C>G	c.(130-132)TCC>TGC	p.S44C	RPTOR_uc002jys.2_Missense_Mutation_p.S44C|RPTOR_uc010wuf.1_Translation_Start_Site|RPTOR_uc010wug.1_Missense_Mutation_p.S44C|RPTOR_uc002jyr.1_Missense_Mutation_p.S44C	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	44					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						GGCTCCAAATCCTTAGCTCAG	0.478													0	0	0	0.010504	0	20	91										G	78519560	C	G	78519560	3	3	79	1	0	0	0	0	1	0	0	0	13665	855	30	1	133	1	RPTOR	17	78519560	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	197726	78519560	2675650	227	23840										
ANKRD30B	374860	broad.mit.edu	37	chr18	14851705	14851705	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	accctaaaactgaaacagaaAacagtaacaaaaagggcatc	6	9	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:14851705A>T	uc010dlo.2	+	36	3585	c.3405A>T	c.(3403-3405)AAA>AAT	p.K1135N	ANKRD30B_uc010xal.1_Missense_Mutation_p.K277N	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1220	Potential.									ovary(1)|skin(1)	2						TGAAACAGAAAACAGTAACAA	0.358													0	0	0	0.007413	0	19	22										T	14851705	A	T	14851705	3	4	79	1	0	0	0	0	1	0	0	0	659	11	1	5	3547	5	ANKRD30B	18	14851705	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08		14851705	63225543	228	23841										
TAF4B	6875	broad.mit.edu	37	chr18	23854694	23854694	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	attgaatactgtaactacccTgaagccttcaagtttgggag	9	8	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:23854694T>A	uc002kvu.3	+	4	1154	c.665T>A	c.(664-666)CTG>CAG	p.L222Q	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.L222Q	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	222					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			GTAACTACCCTGAAGCCTTCA	0.428													0	0	0	0.004007	0	16	101										A	23854694	T	A	23854694	3	1	79	1	0	0	0	0	1	0	0	0	15524	1580	55	5	679	5	TAF4B	18	23854694	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	9002989	23854694	54222554	229	23842										
SYT4	6860	broad.mit.edu	37	chr18	40851713	40851713	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	atcagatttaggcagatgtcGagcttttaagacaaccacag	9	8	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:40851713G>C	uc002law.2	-	3	1303	c.934C>G	c.(934-936)CGA>GGA	p.R312G	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.R294G|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	312	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						GGCAGATGTCGAGCTTTTAAG	0.413													0	0	0	0.010729	0	12	65										C	40851713	G	C	40851713	3	2	79	1	0	0	0	0	1	0	0	0	15473	1066	37	1	351	1	SYT4	18	40851713	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	16997019	40851713	37225535	230	23843										
C3	718	broad.mit.edu	37	chr19	6679429	6679429	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggaactcaccctcagcacagCggcacagttcatcacggcag	10	15	4	0	rs142868256		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:6679429C>T	uc002mfm.2	-	37	4597	c.4535G>A	c.(4534-4536)CGC>CAC	p.R1512H	C3_uc002mfl.2_Missense_Mutation_p.R248H	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1512					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCAGCACAGCGGCACAGTTC	0.572													0	0	0	0.006999	0	38	77										T	6679429	C	T	6679429	3	4	79	1	0	0	0	0	1	0	0	0	2204	768	27	2	476	2	C3	19	6679429	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		6679429	52449554	231	23844										
MUC16	94025	broad.mit.edu	37	chr19	9090928	9090928	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctgagaatatgctggtctctGatattttattatcgagaact	8	6	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:9090928G>A	uc002mkp.2	-	1	1091	c.887C>T	c.(886-888)TCA>TTA	p.S296L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	296	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTGGTCTCTGATATTTTATT	0.517													0	0	0	0.011902	0	43	46										A	9090928	G	A	9090928	3	1	79	1	0	0	0	0	1	0	0	0	9973	1294	45	1	42972	1	MUC16	19	9090928	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2411499	9090928	50038055	232	23845										
ZNF317	57693	broad.mit.edu	37	chr19	9272093	9272093	+	Frame_Shift_Del	DEL	G	G	-													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gctctttgtgtcatccgtgtGgaaaaggctccagtgagcgc							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:9272093delG	uc002mku.2	+	7	2047	c.1772delG	c.(1771-1773)TGGfs	p.W591fs	ZNF317_uc002mkv.2_Frame_Shift_Del_p.W450fs|ZNF317_uc002mkw.2_Frame_Shift_Del_p.W559fs|ZNF317_uc002mkx.2_Frame_Shift_Del_p.W506fs|ZNF317_uc002mky.2_Frame_Shift_Del_p.W474fs	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATCCGTGTGGAAAAGGCTC	0.557																		17	28	---	---								-	9272093	G	-	9272093	7	5	79	1	0	1	0	1	0	0	0	0	17832	1357	47	0	1794	0	ZNF317	19	9272093	Frame_Shift_Del	DEL	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	181165	9272093	49856890	233	23846										
ILF3	3609	broad.mit.edu	37	chr19	10798322	10798322	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acaaggcagctactcctactCgaactcctacaactctcccg	5	17	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:10798322C>T	uc002mpn.2	+	18	2677	c.2360C>T	c.(2359-2361)TCG>TTG	p.S787L	ILF3_uc002mpo.2_Missense_Mutation_p.S791L|ILF3_uc002mpq.2_Nonsense_Mutation_p.R90*	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	787	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TACTCCTACTCGAACTCCTAC	0.597													0	0	0	0.008871	0	21	14										T	10798322	C	T	10798322	3	4	79	1	0	0	0	0	1	0	0	0	7712	893	31	1	2510	1	ILF3	19	10798322	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1526229	10798322	48330661	234	23847										
DDA1	79016	broad.mit.edu	37	chr19	17426805	17426805	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	atcagcaatgggacaaaaagGtgaggcccacagggctctgg	14	9	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:17426805G>T	uc002ngd.2	+	4	325	c.198_splice	c.e4+1	p.K66_splice	DDA1_uc002nge.2_Splice_Site_p.E5_splice	NM_024050	NP_076955	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1											ovary(1)	1						GGACAAAAAGGTGAGGCCCAC	0.323													1	0	3.90053e-15	0.012213	4.34377e-15	34	175										T	17426805	G	T	17426805	5	4	79	1	0	0	0	0	0	0	1	0	4320	1275	44	4	213	4	DDA1	19	17426805	Splice_Site	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	6628483	17426805	41702178	235	23848										
ZNF486	90649	broad.mit.edu	37	chr19	20308312	20308312	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aaattcatagtggagagaaaCcctacatttgtgaagaatgt	9	5	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:20308312C>A	uc002nou.2	+	4	850	c.793C>A	c.(793-795)CCC>ACC	p.P265T		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGGAGAGAAACCCTACATTTG	0.368													1	0	0.00198382	0.001984	0.00202515	7	31										A	20308312	C	A	20308312	3	1	79	1	0	0	0	0	1	0	0	0	17936	507	18	4	807	4	ZNF486	19	20308312	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2881507	20308312	38820671	236	23849										
ZNF486	90649	broad.mit.edu	37	chr19	20308324	20308324	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gagagaaaccctacatttgtGaagaatgtggcaaagccttt	10	7	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:20308324G>A	uc002nou.2	+	4	862	c.805G>A	c.(805-807)GAA>AAA	p.E269K		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	269	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTACATTTGTGAAGAATGTGG	0.373													0	0	0	0.00308	0	8	35										A	20308324	G	A	20308324	3	1	79	1	0	0	0	0	1	0	0	0	17936	1291	45	1	819	1	ZNF486	19	20308324	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	12	20308324	38820659	237	23850										
ZNF681	148213	broad.mit.edu	37	chr19	23927544	23927544	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	atgaattattgtatgtgttgTaatgtgtgacgacaggttaa	11	2	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:23927544T>C	uc002nrk.3	-	4	950	c.808A>G	c.(808-810)ACA>GCA	p.T270A	ZNF681_uc002nrl.3_Missense_Mutation_p.T201A|ZNF681_uc002nrj.3_Missense_Mutation_p.T201A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	270	C2H2-type 4; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GTATGTGTTGTAATGTGTGAC	0.353													0	0	0	0.004007	0	17	47										C	23927544	T	C	23927544	3	2	79	1	0	0	0	0	1	0	0	0	18085	1638	57	5	1133	5	ZNF681	19	23927544	Missense_Mutation	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	3619220	23927544	35201439	238	23851										
ARHGAP33	115703	broad.mit.edu	37	chr19	36278140	36278140	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cctgggggtgccccacccccGccccctaagaacccagcacg	10	21	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:36278140G>A	uc002obs.1	+	21	2275	c.2190G>A	c.(2188-2190)CCG>CCA	p.P730P	ARHGAP33_uc002obt.1_Silent_p.P755P|ARHGAP33_uc010eel.2_Silent_p.P479P|ARHGAP33_uc002obv.1_Silent_p.P479P	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCCCACCCCCGCCCCCTAAGA	0.657													0	0	0	0.007835	0	41	17										A	36278140	G	A	36278140	2	1	79	1	0	0	0	0	0	0	0	1	882	1074	38	2		2	ARHGAP33	19	36278140	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	12350596	36278140	22850843	239	23852										
SPTBN4	57731	broad.mit.edu	37	chr19	41076526	41076526	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctcgcgctccgccccggcccAgggcggctccgcccccgcgc	13	24	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:41076526A>T	uc002ony.2	+	33	7297	c.7211A>T	c.(7210-7212)CAG>CTG	p.Q2404L	SPTBN4_uc002onz.2_Missense_Mutation_p.Q2404L|SPTBN4_uc010egx.2_Missense_Mutation_p.Q1147L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2404					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			gccccggcccagggcggctcc	0.343													0	0	0	0.009096	0	4	2										T	41076526	A	T	41076526	3	4	79	1	0	0	0	0	1	0	0	0	15120	188	7	5	7431	5	SPTBN4	19	41076526	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	4798386	41076526	18052457	240	23853										
PSG2	5670	broad.mit.edu	37	chr19	43579628	43579628	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agagggtcctgttggtttcgGacagctgaaacctatgagtc	13	8	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:43579628G>C	uc002ovr.2	-	3	680	c.587C>G	c.(586-588)TCC>TGC	p.S196C	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.S196C|PSG2_uc010eiq.1_Missense_Mutation_p.S196C|PSG2_uc002ovs.3_Missense_Mutation_p.S196C|PSG2_uc002ovt.3_Missense_Mutation_p.S196C	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	196	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTTGGTTTCGGACAGCTGAAA	0.493													0	0	0	0.01441	0	125	798										C	43579628	G	C	43579628	3	2	79	1	0	0	0	0	1	0	0	0	12655	1174	41	1	432	1	PSG2	19	43579628	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2503102	43579628	15549355	241	23854										
IRGQ	126298	broad.mit.edu	37	chr19	44097062	44097062	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctcgccctcgccgtctgtgcGcacgcagacaagaggcgcat	12	16	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44097062G>A	uc002oww.2	-	2	1106	c.988C>T	c.(988-990)CGC>TGC	p.R330C	IRGQ_uc010eiv.2_Missense_Mutation_p.R330C	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	330							protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				CCGTCTGTGCGCACGCAGACA	0.632													0	0	0	0.013537	0	13	264										A	44097062	G	A	44097062	3	1	79	1	0	0	0	0	1	0	0	0	7839	1087	38	2	887	2	IRGQ	19	44097062	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	517434	44097062	15031921	242	23855										
ZNF229	7772	broad.mit.edu	37	chr19	44933335	44933335	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gcatttgtagggtttctctcCtgtgtgcagtctctgatgca	11	9	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44933335C>T	uc002oze.1	-	6	2055	c.1621G>A	c.(1621-1623)GGA>AGA	p.G541R	ZNF229_uc010ejk.1_Missense_Mutation_p.G195R|ZNF229_uc010ejl.1_Missense_Mutation_p.G535R	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				GGTTTCTCTCCTGTGTGCAGT	0.512													0	0	0	0.01441	0	145	87										T	44933335	C	T	44933335	3	4	79	1	0	0	0	0	1	0	0	0	17779	690	24	2	860	2	ZNF229	19	44933335	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	836273	44933335	14195648	243	23856										
CRX	1406	broad.mit.edu	37	chr19	48342712	48342712	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cgtccccaagaccctccacaGatgtgtgtccagaccctctg	8	17	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:48342712G>A	uc002phq.3	+	4	592	c.388G>A	c.(388-390)GAT>AAT	p.D130N		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	130					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		ACCCTCCACAGATGTGTGTCC	0.567													0	0	0	0.015359	0	37	81										A	48342712	G	A	48342712	3	1	79	1	0	0	0	0	1	0	0	0	3902	942	33	1	398	1	CRX	19	48342712	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	3409377	48342712	10786271	244	23857										
FUT2	2524	broad.mit.edu	37	chr19	49206253	49206253	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctttctcctttcccatggccCacttcatcctctttgtcttt	3	16	4	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:49206253C>A	uc002pke.3	+	2	151	c.40C>A	c.(40-42)CAC>AAC	p.H14N	FUT2_uc010emc.2_Missense_Mutation_p.H14N	NM_001097638	NP_001091107	Q10981	FUT2_HUMAN	fucosyltransferase 2	14	Cytoplasmic (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			central_nervous_system(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		TCCCATGGCCCACTTCATCCT	0.547													1	0	1.1362e-29	0.01441	1.29045e-29	61	184										A	49206253	C	A	49206253	3	1	79	1	0	0	0	0	1	0	0	0	6104	594	21	4	42	4	FUT2	19	49206253	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	863541	49206253	9922730	245	23858										
PPFIA3	8541	broad.mit.edu	37	chr19	49643235	49643235	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cagtgagggcaccccagattCtctgcacaaagcccccaaga	9	15	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:49643235C>T	uc002pmr.2	+	18	2590	c.2258C>T	c.(2257-2259)TCT>TTT	p.S753F	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.S621F|PPFIA3_uc002pmt.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	753						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACCCCAGATTCTCTGCACAAA	0.562													0	0	0	0.01441	0	68	110										T	49643235	C	T	49643235	3	4	79	1	0	0	0	0	1	0	0	0	12311	913	32	1	2324	1	PPFIA3	19	49643235	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	436982	49643235	9485748	246	23859										
HAS1	3036	broad.mit.edu	37	chr19	52220265	52220265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cacagtggaagtagctctgaCaagcccgctccacattgaag	10	12	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:52220265C>T	uc002pxo.1	-	3	919	c.884G>A	c.(883-885)TGT>TAT	p.C295Y	HAS1_uc010epc.1_5'UTR|HAS1_uc010epd.1_Missense_Mutation_p.C260Y|HAS1_uc002pxn.1_Missense_Mutation_p.C302Y|HAS1_uc002pxp.1_Missense_Mutation_p.C294Y	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	295	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GTAGCTCTGACAAGCCCGCTC	0.577													0	0	0	0.01441	0	53	159										T	52220265	C	T	52220265	3	4	79	1	0	0	0	0	1	0	0	0	6961	478	17	2	864	2	HAS1	19	52220265	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	2577030	52220265	6908718	247	23860										
ZNF805	390980	broad.mit.edu	37	chr19	57764890	57764890	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgaagccctatgaatgcacaGagtgtggaaaaacctttagc	10	8	0	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:57764890G>A	uc010ygt.1	+	4	910	c.703G>A	c.(703-705)GAG>AAG	p.E235K	ZNF805_uc010ygu.1_Missense_Mutation_p.E102K	NM_001023563	NP_001018857	Q5CZA5	ZN805_HUMAN	zinc finger protein 805 isoform 1	235	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAATGCACAGAGTGTGGAAA	0.458													0	0	0	0.004672	0	3	18										A	57764890	G	A	57764890	3	1	79	1	0	0	0	0	1	0	0	0	18169	943	33	1	717	1	ZNF805	19	57764890	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	5544625	57764890	1364093	248	23861										
ZNF548	147694	broad.mit.edu	37	chr19	57908460	57908460	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gccatatatttctcccaggaGgagtgggggcaccttgatga	13	9	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:57908460G>T	uc002qom.2	+	2	310	c.60G>T	c.(58-60)GAG>GAT	p.E20D	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.E23D	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTCCCAGGAGGAGTGGGGGC	0.488													1	0	1.15966e-41	0.01441	1.32147e-41	96	171										T	57908460	G	T	57908460	3	4	79	1	0	0	0	0	1	0	0	0	17977	991	35	4	106	4	ZNF548	19	57908460	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	143570	57908460	1220523	249	23862										
ZNF606	80095	broad.mit.edu	37	chr19	58491154	58491154	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccaaaatgtattatatgattGaaagatttaacagcatcagt	6	5	1	3			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:58491154G>A	uc002qqw.2	-	7	1512	c.894C>T	c.(892-894)TTC>TTT	p.F298F	ZNF606_uc010yhp.1_Silent_p.F208F	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	298	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TTATATGATTGAAAGATTTAA	0.318													0	0	0	0.008871	0	21	49										A	58491154	G	A	58491154	2	1	79	1	0	0	0	0	0	0	0	1	18029	1281	45	1		1	ZNF606	19	58491154	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	582694	58491154	637829	250	23863										
A1BG	1	broad.mit.edu	37	chr19	58862857	58862857	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tagtgacctccatcccccagGgccaccgcgttcaggtgaaa	10	15	1	2	rs140428520		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:58862857G>A	uc002qsd.3	-	5	872	c.810C>T	c.(808-810)GCC>GCT	p.A270A	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	270	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CATCCCCCAGGGCCACCGCGT	0.632													0	0	0	0.00308	0	8	46										A	58862857	G	A	58862857	2	1	79	1	0	0	0	0	0	0	0	1	1	1219	43	2		2	A1BG	19	58862857	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	371703	58862857	266126	251	23864										
MAP1LC3A	84557	broad.mit.edu	37	chr20	33147573	33147573	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ctgaaccccacgcaggccttCttcctgctggtgaaccagca	9	16	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:33147573C>T	uc002xaq.1	+	4	391	c.237C>T	c.(235-237)TTC>TTT	p.F79F	MAP1LC3A_uc002xap.1_Silent_p.F83F	NM_032514	NP_115903	Q9H492	MLP3A_HUMAN	microtubule-associated protein 1 light chain 3	79					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding				0						CGCAGGCCTTCTTCCTGCTGG	0.632													0	0	0	0.021523	0	26	69										T	33147573	C	T	33147573	2	4	79	1	0	0	0	0	0	0	0	1	9230	912	32	1		1	MAP1LC3A	20	33147573	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		33147573	29877947	252	23865										
GDF5	8200	broad.mit.edu	37	chr20	34022096	34022096	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttttcgccgctggctgaacaGgtactcatacacggtcttat	9	11	2	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:34022096G>A	uc002xck.1	-	2	1436	c.1117C>T	c.(1117-1119)CTG>TTG	p.L373L	GDF5_uc010gfc.1_Silent_p.L373L|uc002xcj.2_Silent_p.Q169Q|GDF5_uc010zvc.1_Silent_p.L373L	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	373			L -> R (in SYM1; the mature GDF5 protein is detected as the wild-type in the supernatant derived from the mutant transfected cells).		cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TGGCTGAACAGGTACTCATAC	0.597													0	0	0	0.01441	0	57	114										A	34022096	G	A	34022096	2	1	79	1	0	0	0	0	0	0	0	1	6316	991	35	2		2	GDF5	20	34022096	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	874523	34022096	29003424	253	23866										
SAMHD1	25939	broad.mit.edu	37	chr20	35547851	35547851	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tcttcagggatgagaccataTtgttccatgacaggcttaat	9	8	2	2	rs140804613	byFrequency	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:35547851T>C	uc002xgh.1	-	7	898	c.768A>G	c.(766-768)CAA>CAG	p.Q256Q		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	256	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TGAGACCATATTGTTCCATGA	0.358													0	0	0	0.013537	0	13	41										C	35547851	T	C	35547851	2	2	79	1	0	0	0	0	0	0	0	1	13828	1490	52	5		5	SAMHD1	20	35547851	Silent	SNP	T	TCGA-FD-A3SJ-01A-12D-A22Z-08	1525755	35547851	27477669	254	23867										
SPATA2	9825	broad.mit.edu	37	chr20	48522186	48522187	+	Frame_Shift_Del	DEL	GG	GG	-													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	acgagatgggagagctgggtGgacttgtagttcagctggtt							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:48522186_48522187delGG	uc010gie.2	-	3	1882_1883	c.1532_1533delCC	c.(1531-1533)TCCfs	p.S511fs	SPATA2_uc002xuw.2_Frame_Shift_Del_p.S511fs|SPATA2_uc010zyn.1_Frame_Shift_Del_p.S374fs	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	511					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			AGAGCTGGGTGGACTTGTAGTT	0.54																		10	100	---	---								-	48522187	GG	-	48522186	7	5	79	1	0	1	0	1	0	0	0	0	15004	1335	47	0	33	0	SPATA2	20	48522186	Frame_Shift_Del	DEL	GG	TCGA-FD-A3SJ-01A-12D-A22Z-08	12974335	48522186	14503334	255	23868										
NFATC2	4773	broad.mit.edu	37	chr20	50139915	50139915	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ggggtacccagccggggagcCgtggtcctggggtgccacgt	19	12	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:50139915C>T	uc002xwd.2	-	2	1085	c.865G>A	c.(865-867)GGC>AGC	p.G289S	NFATC2_uc002xwc.2_Missense_Mutation_p.G289S|NFATC2_uc010zyv.1_Missense_Mutation_p.G70S|NFATC2_uc010zyw.1_Missense_Mutation_p.G70S|NFATC2_uc010zyx.1_Missense_Mutation_p.G269S|NFATC2_uc010zyy.1_Missense_Mutation_p.G70S|NFATC2_uc010zyz.1_Missense_Mutation_p.G70S|NFATC2_uc002xwe.2_Missense_Mutation_p.G269S	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	289					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GCCGGGGAGCCGTGGTCCTGG	0.711													0	0	0	0.014758	0	4	14										T	50139915	C	T	50139915	3	4	79	1	0	0	0	0	1	0	0	0	10362	652	23	2	1996	2	NFATC2	20	50139915	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	1617729	50139915	12885605	256	23869										
GABPA	2551	broad.mit.edu	37	chr21	27130395	27130395	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aggaattcagcatgaccgatAtagacctcaccacactcaac	6	13	3	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:27130395A>G	uc002ylx.3	+	6	1155	c.628A>G	c.(628-630)ATA>GTA	p.I210V	GABPA_uc002yly.3_Missense_Mutation_p.I210V	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	210	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						CATGACCGATATAGACCTCAC	0.438													0	0	0	0.013537	0	11	68										G	27130395	A	G	27130395	3	3	79	1	0	0	0	0	1	0	0	0	6157	449	16	5	646	5	GABPA	21	27130395	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08		27130395	20999500	257	23870										
CLDN8	9073	broad.mit.edu	37	chr21	31587705	31587705	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aaaaaacgcagcagaacagaGctcctccaacaatcagcacc	6	14	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:31587705G>T	uc002ynu.1	-	1	614	c.539C>A	c.(538-540)GCT>GAT	p.A180D		NM_199328	NP_955360	P56748	CLD8_HUMAN	claudin 8	180	Helical; (Potential).				calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GCAGAACAGAGCTCCTCCAAC	0.453													1	0	0.00909568	0.009096	0.00917594	4	65										T	31587705	G	T	31587705	3	4	79	1	0	0	0	0	1	0	0	0	3491	971	34	4	142	4	CLDN8	21	31587705	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	4457310	31587705	16542190	258	23871										
RIPK4	54101	broad.mit.edu	37	chr21	43161747	43161747	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gtgcatgggcgtccggccctCaaagtccacctcgttgaccg	12	15	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:43161747C>T	uc002yzn.1	-	8	1654	c.1606G>A	c.(1606-1608)GAG>AAG	p.E536K		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	536						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GTCCGGCCCTCAAAGTCCACC	0.647													0	0	0	0.00499	0	17	47										T	43161747	C	T	43161747	3	4	79	1	0	0	0	0	1	0	0	0	13383	835	29	1	752	1	RIPK4	21	43161747	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	11574042	43161747	4968148	259	23872										
UBASH3A	53347	broad.mit.edu	37	chr21	43836631	43836631	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cccaccaccagaggacgctgGagcagctggccagagccatc	12	16	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:43836631G>C	uc002zbe.2	+	6	784	c.748G>C	c.(748-750)GAG>CAG	p.E250Q	UBASH3A_uc002zbf.2_Missense_Mutation_p.E212Q|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.E212Q	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	250						cytosol|nucleus				ovary(3)	3						GAGGACGCTGGAGCAGCTGGC	0.597													0	0	0	0.003163	0	16	21										C	43836631	G	C	43836631	3	2	79	1	0	0	0	0	1	0	0	0	16836	1175	41	1	770	1	UBASH3A	21	43836631	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	674884	43836631	4293264	260	23873										
PFKL	5211	broad.mit.edu	37	chr21	45746744	45746744	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gagcatggacaagggcttctGaggccagccatgcccacgcc	13	14	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:45746744G>A	uc002zel.2	+	22	2401	c.2342G>A	c.(2341-2343)TGA>TAA	p.*781*	PFKL_uc002zek.2_Silent_p.*828*|PFKL_uc002zem.2_Silent_p.*368*|PFKL_uc002zen.2_Silent_p.*368*	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	781					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		AAGGGCTTCTGAGGCCAGCCA	0.667													0	0	0	0.014758	0	5	4										A	45746744	G	A	45746744	2	1	79	1	0	0	0	0	0	0	0	1	11764	1285	45	1		1	PFKL	21	45746744	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	1910113	45746744	2383151	261	23874										
TRPM2	7226	broad.mit.edu	37	chr21	45811248	45811248	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	agaacggggtgcagctgaagGagtttgtcacctgggacacc	15	9	1	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:45811248G>A	uc002zet.1	+	12	1747	c.1534G>A	c.(1534-1536)GAG>AAG	p.E512K	TRPM2_uc002zeu.1_Missense_Mutation_p.E512K|TRPM2_uc002zew.1_Missense_Mutation_p.E512K|TRPM2_uc010gpt.1_Missense_Mutation_p.E512K|TRPM2_uc002zex.1_Missense_Mutation_p.E298K|TRPM2_uc002zey.1_Missense_Mutation_p.E25K	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	512	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAGCTGAAGGAGTTTGTCAC	0.567													0	0	0	0.013726	0	33	60										A	45811248	G	A	45811248	3	1	79	1	0	0	0	0	1	0	0	0	16583	1175	41	1	1576	1	TRPM2	21	45811248	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	64504	45811248	2318647	262	23875										
POTEH	23784	broad.mit.edu	37	chr22	16287675	16287675	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cttgccgctccccctgcaccAggggaagcagtggcagcacc	12	17	0	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:16287675A>G	uc010gqp.2	-	1	263	c.211T>C	c.(211-213)TGG>CGG	p.W71R	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	71										skin(1)	1						CCCCTGCACCAGGGGAAGCAG	0.582													0	0	0	0.01441	0	53	140										G	16287675	A	G	16287675	3	3	79	1	0	0	0	0	1	0	0	0	12267	188	7	5	1466	5	POTEH	22	16287675	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08		16287675	35016891	263	23876										
MRPL40	64976	broad.mit.edu	37	chr22	19423455	19423455	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	aggtacaatgacatcaccaaGgtgtacacacaagtggagtt	10	8	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:19423455G>C	uc002zpg.2	+	4	633	c.591G>C	c.(589-591)AAG>AAC	p.K197N	HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zph.2_Missense_Mutation_p.K153N	NM_003776	NP_003767	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40 precursor	197					anatomical structure morphogenesis	mitochondrial ribosome|nucleus					0	Colorectal(54;0.0993)					ACATCACCAAGGTGTACACAC	0.502													0	0	0	0.010729	0	11	50										C	19423455	G	C	19423455	3	2	79	1	0	0	0	0	1	0	0	0	9804	991	35	4	605	4	MRPL40	22	19423455	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	3135780	19423455	31881111	264	23877										
TCN2	6948	broad.mit.edu	37	chr22	31010392	31010392	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	accagtatggcctgggcattCtggccctgtgtctccaccag	11	14	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:31010392C>G	uc003aip.1	+	4	642	c.484C>G	c.(484-486)CTG>GTG	p.L162V	TCN2_uc003aiq.1_Missense_Mutation_p.L158V|TCN2_uc003air.1_Missense_Mutation_p.L135V	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	162					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCTGGGCATTCTGGCCCTGTG	0.577													0	0	0	0.007291	0	29	25										G	31010392	C	G	31010392	3	3	79	1	0	0	0	0	1	0	0	0	15704	912	32	1	498	1	TCN2	22	31010392	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	11586937	31010392	20294174	265	23878										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31884623	31884623	+	Frame_Shift_Del	DEL	G	G	-													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccttacttttgtatagcgatGggggcatttggaggcaggag							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:31884623delG	uc003akz.1	-	2	246	c.82delC	c.(82-84)CATfs	p.H28fs	EIF4ENIF1_uc003ala.1_Frame_Shift_Del_p.H28fs|EIF4ENIF1_uc003alb.1_Frame_Shift_Del_p.H28fs|EIF4ENIF1_uc003alc.1_Frame_Shift_Del_p.H28fs	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	28						nucleus	protein binding|protein transporter activity			ovary(1)	1						GTATAGCGATGGGGGCATTTG	0.413																		33	21	---	---								-	31884623	G	-	31884623	7	5	79	1	0	1	0	1	0	0	0	0	5035	1348	47	0	2950	0	EIF4ENIF1	22	31884623	Frame_Shift_Del	DEL	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	874231	31884623	19419943	266	23879										
CACNG2	10369	broad.mit.edu	37	chr22	37098579	37098579	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaaggcagcgaaagcaccaaCggtggttaaaagcatttgaa	12	7	0	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:37098579C>T	uc003aps.1	-	1	325	c.43G>A	c.(43-45)GTT>ATT	p.V15I	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	15	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						AAAGCACCAACGGTGGTTAAA	0.478													0	0	0	0.01441	0	57	60										T	37098579	C	T	37098579	3	4	79	1	0	0	0	0	1	0	0	0	2557	536	19	2	944	2	CACNG2	22	37098579	Missense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	5213956	37098579	14205987	267	23880										
MCHR1	2847	broad.mit.edu	37	chr22	41077323	41077323	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	actgtccaccccatctcttcCacgaagttccggaagccctc	6	18	1	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:41077323C>T	uc003ayz.2	+	2	928	c.660C>T	c.(658-660)TCC>TCT	p.S220S	MCHR1_uc003aza.2_Silent_p.S109S	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	220	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						CCATCTCTTCCACGAAGTTCC	0.587													0	0	0	0.004656	0	26	51										T	41077323	C	T	41077323	2	4	79	1	0	0	0	0	0	0	0	1	9382	581	21	2		2	MCHR1	22	41077323	Silent	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	3978744	41077323	10227243	268	23881										
MAP3K15	389840	broad.mit.edu	37	chrX	19390910	19390910	+	Frame_Shift_Del	DEL	C	C	-													0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	cctccggggacgaggccaagCcccggtcttccaaggctgag							TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:19390910delC	uc004czk.1	-	23	3031	c.1394delG	c.(1393-1395)GGCfs	p.G465fs	MAP3K15_uc004czj.1_Frame_Shift_Del_p.G425fs|MAP3K15_uc004czi.1_5'UTR	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	990							ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					CGAGGCCAAGCCCCGGTCTTC	0.612																		20	37	---	---								-	19390910	C	-	19390910	7	5	79	1	0	1	0	1	0	0	0	0	9249	739	26	0	1004	0	MAP3K15	23	19390910	Frame_Shift_Del	DEL	C	TCGA-FD-A3SJ-01A-12D-A22Z-08		19390910	135879650	269	23882										
KDM6A	7403	broad.mit.edu	37	chrX	44870231	44870231	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tgcctttttatatggtcttgGtttggtctacttccattata	7	7	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:44870231G>T	uc004dge.3	+	5	785	c.410G>T	c.(409-411)GGT>GTT	p.G137V	KDM6A_uc010nhk.2_Missense_Mutation_p.G137V|KDM6A_uc011mkz.1_Missense_Mutation_p.G137V|KDM6A_uc011mla.1_Missense_Mutation_p.G137V|KDM6A_uc011mlb.1_Missense_Mutation_p.G137V|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	137	TPR 2.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TATGGTCTTGGTTTGGTCTAC	0.299			D|N|F|S		renal|oesophageal SCC|MM								1	0	5.18039e-06	0.00308	5.4173e-06	6	6										T	44870231	G	T	44870231	3	4	79	1	0	0	0	0	1	0	0	0	8137	1261	44	4	428	4	KDM6A	23	44870231	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	25479321	44870231	110400329	270	23883										
WNK3	65267	broad.mit.edu	37	chrX	54265480	54265480	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	tggctccaccgcttgacacaGcagcaggataggcctctgga	12	13	1	1			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:54265480G>A	uc004dtd.1	-	18	4143	c.3704C>T	c.(3703-3705)GCT>GTT	p.A1235V	WNK3_uc004dtc.1_Missense_Mutation_p.A1235V	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1235					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GCTTGACACAGCAGCAGGATA	0.388													0	0	0	0.004672	0	3	17										A	54265480	G	A	54265480	3	1	79	1	0	0	0	0	1	0	0	0	17376	971	34	2	1726	2	WNK3	23	54265480	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	9395249	54265480	101005080	271	23884										
ALAS2	212	broad.mit.edu	37	chrX	55050275	55050275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	gaaaatggcttccttaggctGactgagaccagggagctagg	14	8	0	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:55050275G>A	uc004dua.3	-	4	468	c.330C>T	c.(328-330)GTC>GTT	p.V110V	ALAS2_uc004dub.3_Intron|ALAS2_uc004dud.3_Intron	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	110					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	TCCTTAGGCTGACTGAGACCA	0.507													0	0	0	0.004672	0	3	6										A	55050275	G	A	55050275	2	1	79	1	0	0	0	0	0	0	0	1	485	1277	45	1		1	ALAS2	23	55050275	Silent	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	784795	55050275	100220285	272	23885										
ACRC	93953	broad.mit.edu	37	chrX	70811992	70811992	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ttacatccttaatgttcagtCaagcagtgatgacaccagtg	8	9	2	2			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:70811992C>G	uc004eae.2	+	3	581	c.80C>G	c.(79-81)TCA>TGA	p.S27*	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	27						nucleus				ovary(3)	3	Renal(35;0.156)					AATGTTCAGTCAAGCAGTGAT	0.383													0	0	0	0.00499	0	15	16										G	70811992	C	G	70811992	4	3	79	1	0	0	0	0	0	1	0	0	171	838	29	1	86	1	ACRC	23	70811992	Nonsense_Mutation	SNP	C	TCGA-FD-A3SJ-01A-12D-A22Z-08	15761717	70811992	84458568	273	23886										
FGF13	2258	broad.mit.edu	37	chrX	137790983	137790983	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	attttgcagtcacttactgtAagtgctgtcctcatctttgg	8	9	3	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:137790983A>T	uc004fam.2	-	2	957	c.295T>A	c.(295-297)TAC>AAC	p.Y99N	FGF13_uc004fan.2_Missense_Mutation_p.Y46N|FGF13_uc011mwi.1_Missense_Mutation_p.Y80N|FGF13_uc004faq.2_Missense_Mutation_p.Y109N|FGF13_uc004far.2_Missense_Mutation_p.Y80N|FGF13_uc011mwj.1_Missense_Mutation_p.Y109N|FGF13_uc011mwk.1_Missense_Mutation_p.Y53N	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	99					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CACTTACTGTAAGTGCTGTCC	0.383													0	0	0	0.012213	0	31	50										T	137790983	A	T	137790983	3	4	79	1	0	0	0	0	1	0	0	0	5842	362	13	5	458	5	FGF13	23	137790983	Missense_Mutation	SNP	A	TCGA-FD-A3SJ-01A-12D-A22Z-08	66978991	137790983	17479577	274	23887										
CDR1	1038	broad.mit.edu	37	chrX	139866323	139866323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	91	1.0664022539553e-26	3.33273075429505	4.0503517215846	2.85858832947874	0.773641968592921	0.870583303982605	64	ccctcaaatccatagcttccGaaaaatccaggtcttccagg	6	14	2	0			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:139866323G>A	uc004fbg.1	-	1	401	c.209C>T	c.(208-210)TCG>TTG	p.S70L	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	70	23 X 6 AA approximate repeats.|12.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CATAGCTTCCGAAAAATCCAG	0.453													0	0	0	0.015359	0	34	40										A	139866323	G	A	139866323	3	1	79	1	0	0	0	0	1	0	0	0	3171	1059	37	1	583	1	CDR1	23	139866323	Missense_Mutation	SNP	G	TCGA-FD-A3SJ-01A-12D-A22Z-08	2075340	139866323	15404237	275	23888										
PANK4	55229	broad.mit.edu	37	chr1	2453183	2453183	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggagtggtcgaaagaccgcaCcttggcgactttgtgctgta	14	9	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:2453183C>G	uc001ajm.1	-	2	190	c.181G>C	c.(181-183)GTG>CTG	p.V61L	PANK4_uc010nza.1_Missense_Mutation_p.V61L	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	61					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AAAGACCGCACCTTGGCGACT	0.607													0	0	0	0.010771	0	44	138										G	2453183	C	G	2453183	3	3	80	1	0	0	0	0	1	0	0	0	11419	507	18	4	2212	4	PANK4	1	2453183	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		2453183	246797438	1	23889										
ENO1	2023	broad.mit.edu	37	chr1	8927305	8927305	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agaatggcgttcgcaccaaaCttagctagaacagaagagaa	10	8	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:8927305C>T	uc001apj.1	-	6	466	c.315G>A	c.(313-315)AAG>AAA	p.K105K	ENO1_uc001api.1_Silent_p.K9K|ENO1_uc001apk.1_Silent_p.K50K|ENO1_uc001apl.1_Silent_p.K105K|ENO1_uc009vmi.1_Silent_p.K62K|ENO1_uc009vmj.1_Silent_p.K105K|ENO1_uc009vmk.1_Intron|ENO1_uc009vml.1_Silent_p.K105K	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	105	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TCGCACCAAACTTAGCTAGAA	0.542													0	0	0	0.003755	0	35	82										T	8927305	C	T	8927305	2	4	80	1	0	0	0	0	0	0	0	1	5121	564	20	2		2	ENO1	1	8927305	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	6474122	8927305	240323316	2	23890										
ARID1A	8289	broad.mit.edu	37	chr1	27094374	27094374	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agatgtgggtggaccgttatCtggccttcactgaggagaag	15	7	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:27094374C>T	uc001bmv.1	+	11	3455	c.3082C>T	c.(3082-3084)CTG>TTG	p.L1028L	ARID1A_uc001bmt.1_Silent_p.L1028L|ARID1A_uc001bmu.1_Silent_p.L1028L|ARID1A_uc001bmw.1_Silent_p.L645L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1028	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGACCGTTATCTGGCCTTCAC	0.502			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	51	100										T	27094374	C	T	27094374	2	4	80	1	0	0	0	0	0	0	0	1	913	912	32	1		1	ARID1A	1	27094374	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	18167069	27094374	222156247	3	23891										
CDCA8	55143	broad.mit.edu	37	chr1	38161616	38161616	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aaacaggccctggaagaggcGgcaacagtaagtgacctttc	12	10	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:38161616G>A	uc001cbr.2	+	4	365	c.258G>A	c.(256-258)GCG>GCA	p.A86A	CDCA8_uc001cbs.2_Silent_p.A86A|CDCA8_uc010oih.1_Silent_p.A19A	NM_018101	NP_060571	Q53HL2	BOREA_HUMAN	cell division cycle associated 8	86	Required for centromere localization.|Required for interaction with SENP3.|Required to form a minimal CPC core complex that localizes to the central spindle and midbody and properly executes the role of the CPC during cytokinesis.				cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGAAGAGGCGGCAACAGTAA	0.408													0	0	0	0.004482	0	9	42										A	38161616	G	A	38161616	2	1	80	1	0	0	0	0	0	0	0	1	3092	1103	39	2		2	CDCA8	1	38161616	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	11067242	38161616	211089005	4	23892										
IPO13	9670	broad.mit.edu	37	chr1	44423127	44423127	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atcgcagagaccattgacgtCaactattctgatgtggtgcc	10	10	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:44423127C>T	uc001ckx.2	+	7	2241	c.1446C>T	c.(1444-1446)GTC>GTT	p.V482V		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	482	HEAT 8.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCATTGACGTCAACTATTCTG	0.562													0	0	0	0.012319	0	11	105										T	44423127	C	T	44423127	2	4	80	1	0	0	0	0	0	0	0	1	7794	813	29	1		1	IPO13	1	44423127	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	6261511	44423127	204827494	5	23893										
IPO13	9670	broad.mit.edu	37	chr1	44423149	44423150	+	Missense_Mutation	DNP	GG	GG	TT													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	actattctgatgtggtgcctGggctcattggcctcatccca							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:44423149_44423150GG>TT	uc001ckx.2	+	7	2263_2264	c.1468_1469GG>TT	c.(1468-1470)GGG>TTG	p.G490L		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	490	HEAT 8.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGTGGTGCCTGGGCTCATTGGC	0.559													0	0	0	0.004672	0	12	116										TT	44423150	GG	TT	44423149	3	4	80	1	0	0	0	0	1	0	0	0	7794	1348	47	4	1494	4	IPO13	1	44423149	Missense_Mutation	DNP	GG	TCGA-FD-A3SL-01A-21D-A22Z-08	22	44423149	204827472	6	23894										
ATG4C	84938	broad.mit.edu	37	chr1	63284996	63284996	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atggaccagctgtggttgctCacattttaaggtaaaattgt	10	6	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:63284996C>G	uc001dat.2	+	5	877	c.715C>G	c.(715-717)CAC>GAC	p.H239D	ATG4C_uc001dau.2_Missense_Mutation_p.H239D	NM_178221	NP_835739	Q96DT6	ATG4C_HUMAN	APG4 autophagy 4 homolog C isoform 8	239					autophagic vacuole assembly|protein targeting to membrane|proteolysis	cytosol|extracellular region	cysteine-type endopeptidase activity			ovary(1)	1						TGTGGTTGCTCACATTTTAAG	0.363													0	0	0	0.00632	0	27	63										G	63284996	C	G	63284996	3	3	80	1	0	0	0	0	1	0	0	0	1098	826	29	1	729	1	ATG4C	1	63284996	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	18861847	63284996	185965625	7	23895										
LEPR	3953	broad.mit.edu	37	chr1	66074462	66074462	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cactgcctccatccagtgtgAaagcagaaattactataaac	6	11	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:66074462A>G	uc001dci.2	+	12	1832	c.1630A>G	c.(1630-1632)AAA>GAA	p.K544E	LEPR_uc001dcg.2_Missense_Mutation_p.K544E|LEPR_uc001dch.2_Missense_Mutation_p.K544E|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.K544E|LEPR_uc001dck.2_Missense_Mutation_p.K544E	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	544	Extracellular (Potential).|Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATCCAGTGTGAAAGCAGAAAT	0.313													0	0	0	0.00308	0	8	50										G	66074462	A	G	66074462	3	3	80	1	0	0	0	0	1	0	0	0	8728	247	9	5	1668	5	LEPR	1	66074462	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	2789466	66074462	183176159	8	23896										
DDAH1	23576	broad.mit.edu	37	chr1	85824470	85824470	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gccatctaaagttgcattttCatctttcatctctactatat	3	10	5	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:85824470C>G	uc001dlb.2	-	2	525	c.364G>C	c.(364-366)GAA>CAA	p.E122Q	DDAH1_uc001dlc.2_Missense_Mutation_p.E19Q|uc001dla.1_Intron|DDAH1_uc010osb.1_Missense_Mutation_p.E22Q|DDAH1_uc009wco.2_Missense_Mutation_p.E19Q	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	122					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	GTTGCATTTTCATCTTTCATC	0.284													0	0	0	0.00632	0	24	74										G	85824470	C	G	85824470	3	3	80	1	0	0	0	0	1	0	0	0	4321	835	29	1	513	1	DDAH1	1	85824470	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	19750008	85824470	163426151	9	23897										
HS2ST1	9653	broad.mit.edu	37	chr1	87563566	87563566	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtggctcagactgtgctccaGagaagctctggcttcaaatc	11	11	3	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:87563566G>C	uc010osk.1	+	5	1019	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	HS2ST1_uc001dmc.3_Missense_Mutation_p.E212Q|LOC339524_uc001dme.1_Missense_Mutation_p.E173Q	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	212	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CTGTGCTCCAGAGAAGCTCTG	0.458													0	0	0	0.010818	0	30	64										C	87563566	G	C	87563566	3	2	80	1	0	0	0	0	1	0	0	0	7362	943	33	1	652	1	HS2ST1	1	87563566	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1739096	87563566	161687055	10	23898										
TGFBR3	7049	broad.mit.edu	37	chr1	92181853	92181853	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccctgggagggcaccaaaaaGaggtcagtgttgtatagctc	13	9	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:92181853G>A	uc001doh.2	-	12	2272	c.1806C>T	c.(1804-1806)CTC>CTT	p.L602L	TGFBR3_uc009wde.2_Silent_p.L379L|TGFBR3_uc010osy.1_Silent_p.L560L|TGFBR3_uc001doi.2_Silent_p.L601L|TGFBR3_uc001doj.2_Silent_p.L601L	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	602	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GCACCAAAAAGAGGTCAGTGT	0.502													0	0	0	0.003163	0	15	40										A	92181853	G	A	92181853	2	1	80	1	0	0	0	0	0	0	0	1	15820	929	33	1		1	TGFBR3	1	92181853	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	4618287	92181853	157068768	11	23899										
C1orf146	388649	broad.mit.edu	37	chr1	92710355	92710355	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gattcctgggttgtaacttaCgaatacttccagtacacaac	7	10	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:92710355C>G	uc001doq.2	+	5	421	c.349C>G	c.(349-351)CGA>GGA	p.R117G	C1orf146_uc010ote.1_Missense_Mutation_p.R58G	NM_001012425	NP_001012425	Q5VVC0	CA146_HUMAN	hypothetical protein LOC388649	117										ovary(1)	1		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		TTGTAACTTACGAATACTTCC	0.353													0	0	0	0.004878	0	33	52										G	92710355	C	G	92710355	3	3	80	1	0	0	0	0	1	0	0	0	2003	528	19	4	363	4	C1orf146	1	92710355	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	528502	92710355	156540266	12	23900										
PTBP2	58155	broad.mit.edu	37	chr1	97236333	97236333	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	actattctgctgtgacacctCatcttcgtaaccaaccaata	4	13	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:97236333C>G	uc001drq.2	+	5	604	c.358C>G	c.(358-360)CAT>GAT	p.H120D	PTBP2_uc001drn.2_Missense_Mutation_p.H120D|PTBP2_uc001dro.2_Missense_Mutation_p.H120D|PTBP2_uc010otz.1_Missense_Mutation_p.H131D|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.H68D|PTBP2_uc001drr.2_Missense_Mutation_p.H120D|PTBP2_uc010oua.1_Missense_Mutation_p.H128D|PTBP2_uc001dru.2_RNA|PTBP2_uc001drm.2_Missense_Mutation_p.H120D	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	120	RRM 1.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TGTGACACCTCATCTTCGTAA	0.323													0	0	0	0.013726	0	34	71										G	97236333	C	G	97236333	3	3	80	1	0	0	0	0	1	0	0	0	12726	826	29	1	376	1	PTBP2	1	97236333	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4525978	97236333	152014288	13	23901										
HIPK1	204851	broad.mit.edu	37	chr1	114483496	114483496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cacaaccaccactgtgaccaCaaagagtagcagttccagcg	8	14	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:114483496C>T	uc001eem.2	+	2	652	c.491C>T	c.(490-492)ACA>ATA	p.T164I	HIPK1_uc001eel.2_Missense_Mutation_p.T164I|HIPK1_uc001een.2_Missense_Mutation_p.T164I	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTGTGACCACAAAGAGTAGC	0.517													0	0	0	0.007835	0	40	62										T	114483496	C	T	114483496	3	4	80	1	0	0	0	0	1	0	0	0	7116	478	17	2	493	2	HIPK1	1	114483496	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	17247163	114483496	134767125	14	23902										
VANGL1	81839	broad.mit.edu	37	chr1	116206768	116206768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tctcccttgtggatgccctcCtcttcatccattacctggcc	6	17	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:116206768C>T	uc001efv.1	+	4	962	c.691C>T	c.(691-693)CTC>TTC	p.L231F	VANGL1_uc009wgy.1_Missense_Mutation_p.L229F|VANGL1_uc001efw.1_Missense_Mutation_p.L231F	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	231	Helical; Name=4; (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GGATGCCCTCCTCTTCATCCA	0.572													0	0	0	0.014323	0	22	86										T	116206768	C	T	116206768	3	4	80	1	0	0	0	0	1	0	0	0	17116	681	24	2	701	2	VANGL1	1	116206768	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1723272	116206768	133043853	15	23903										
ADAMTSL4	54507	broad.mit.edu	37	chr1	150526564	150526564	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccctattccaagatgttctgGggagagtgaacagctaagag	12	8	1	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:150526564G>C	uc001eux.2	+	6	1333	c.1097G>C	c.(1096-1098)GGG>GCG	p.G366A	ADAMTSL4_uc001euw.2_Missense_Mutation_p.G366A|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.G366A|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.G366A	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	366					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AGATGTTCTGGGGAGAGTGAA	0.652													0	0	0	0.013537	0	12	46										C	150526564	G	C	150526564	3	2	80	1	0	0	0	0	1	0	0	0	277	1232	43	4	1111	4	ADAMTSL4	1	150526564	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	34319796	150526564	98724057	16	23904										
MEX3A	92312	broad.mit.edu	37	chr1	156051352	156051352	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttaccttgcctgcccacgatCtcggccacgtgctcggaggt	11	15	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:156051352C>G	uc001fnd.3	-	1	438	c.438G>C	c.(436-438)GAG>GAC	p.E146D	LMNA_uc001fnf.1_5'Flank	NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	146	KH 1.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					TGCCCACGATCTCGGCCACGT	0.637													0	0	0	0.009096	0	4	9										G	156051352	C	G	156051352	3	3	80	1	0	0	0	0	1	0	0	0	9509	912	32	1	1132	1	MEX3A	1	156051352	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	5524788	156051352	93199269	17	23905										
OR10J3	441911	broad.mit.edu	37	chr1	159283465	159283465	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aaagagcattaaaaattagtAcatatttataaacgcaaagg	6	4	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:159283465A>G	uc010piu.1	-	1	985	c.985T>C	c.(985-987)TAC>CAC	p.Y329H		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	329	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					AAAAATTAGTACATATTTATA	0.393													0	0	0	0.013726	0	32	66										G	159283465	A	G	159283465	3	3	80	1	0	0	0	0	1	0	0	0	10911	391	14	5	6	5	OR10J3	1	159283465	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	3232113	159283465	89967156	18	23906										
POU2F1	5451	broad.mit.edu	37	chr1	167339439	167339439	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttacaggctgctgctcagtcTttaaatgtacaggtaagctg	10	8	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:167339439T>G	uc001gec.2	+	5	363	c.201T>G	c.(199-201)TCT>TCG	p.S67S	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Silent_p.S65S|POU2F1_uc001gee.2_Silent_p.S67S|POU2F1_uc010plh.1_Silent_p.S67S|POU2F1_uc001gef.2_Silent_p.S79S|POU2F1_uc001geg.2_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	67					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						CTGCTCAGTCTTTAAATGTAC	0.358													0	0	0	0.008361	0	28	134										G	167339439	T	G	167339439	2	3	80	1	0	0	0	0	0	0	0	1	12271	1596	56	5		5	POU2F1	1	167339439	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	8055974	167339439	81911182	19	23907										
DCAF6	55827	broad.mit.edu	37	chr1	167921068	167921068	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atttatccaaagattaaaacTtgaagcaacccttaatgtgc	5	8	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:167921068T>G	uc001gew.2	+	2	370	c.128T>G	c.(127-129)CTT>CGT	p.L43R	DCAF6_uc001gev.2_Missense_Mutation_p.L43R|DCAF6_uc001gex.2_Missense_Mutation_p.L43R|DCAF6_uc010plk.1_Missense_Mutation_p.L43R	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	43					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AGATTAAAACTTGAAGCAACC	0.279													0	0	0	0.01441	0	55	32										G	167921068	T	G	167921068	3	3	80	1	0	0	0	0	1	0	0	0	4274	1609	56	5	134	5	DCAF6	1	167921068	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	581629	167921068	81329553	20	23908										
SELE	6401	broad.mit.edu	37	chr1	169696572	169696572	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccattgagcgtccatccttcAggacaggcgaacttgcacac	9	14	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:169696572A>C	uc001ggm.3	-	10	1720	c.1563T>G	c.(1561-1563)CCT>CCG	p.P521P	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	521	Extracellular (Potential).|Sushi 6.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					TCCATCCTTCAGGACAGGCGA	0.542													0	0	0	0.01441	0	55	56										C	169696572	A	C	169696572	2	2	80	1	0	0	0	0	0	0	0	1	14013	175	7	5		5	SELE	1	169696572	Silent	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	1775504	169696572	79554049	21	23909										
ABL2	27	broad.mit.edu	37	chr1	179077602	179077602	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tttcagagtgggtgagataaGgactggcactttgtggttgt	15	4	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:179077602G>A	uc001gmj.3	-	12	3087	c.2800C>T	c.(2800-2802)CTT>TTT	p.L934F	ABL2_uc010pnf.1_Missense_Mutation_p.L831F|ABL2_uc010png.1_Missense_Mutation_p.L810F|ABL2_uc010pnh.1_Missense_Mutation_p.L913F|ABL2_uc001gmg.3_Missense_Mutation_p.L816F|ABL2_uc001gmi.3_Missense_Mutation_p.L919F|ABL2_uc001gmh.3_Missense_Mutation_p.L898F|ABL2_uc010pne.1_Missense_Mutation_p.L795F	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	934	Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GGTGAGATAAGGACTGGCACT	0.557			T	ETV6	AML								0	0	0	0.01441	0	66	55										A	179077602	G	A	179077602	3	1	80	1	0	0	0	0	1	0	0	0	93	1000	35	2	752	2	ABL2	1	179077602	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	9381030	179077602	70173019	22	23910										
GLT25D2	23127	broad.mit.edu	37	chr1	183908076	183908076	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tctccgtgtcactcaggtacCccggctggcctgtgtagtgc	12	14	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:183908076C>T	uc001gqr.2	-	12	2072	c.1700G>A	c.(1699-1701)GGG>GAG	p.G567E	GLT25D2_uc010poj.1_Intron|GLT25D2_uc001gqp.2_Missense_Mutation_p.G175E|GLT25D2_uc001gqq.2_Missense_Mutation_p.G304E|GLT25D2_uc001gqs.2_Missense_Mutation_p.G447E	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	567					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						ACTCAGGTACCCCGGCTGGCC	0.562													0	0	0	0.00499	0	18	134										T	183908076	C	T	183908076	3	4	80	1	0	0	0	0	1	0	0	0	6467	623	22	2	184	2	GLT25D2	1	183908076	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4830474	183908076	65342545	23	23911										
HMCN1	83872	broad.mit.edu	37	chr1	186022986	186022986	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgctgactgattccatggggCgagttagaattttatctggg	13	6	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:186022986C>A	uc001grq.1	+	44	6959	c.6730C>A	c.(6730-6732)CGA>AGA	p.R2244R		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2244	Ig-like C2-type 20.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTCCATGGGGCGAGTTAGAAT	0.428													1	0	1.15088e-07	0.004007	1.21879e-07	16	95										A	186022986	C	A	186022986	2	1	80	1	0	0	0	0	0	0	0	1	7220	760	27	4		4	HMCN1	1	186022986	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	2114910	186022986	63227635	24	23912										
KIF14	9928	broad.mit.edu	37	chr1	200569537	200569537	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgcagtttcattcttaaggaTgttatttcttgccgacagag	9	7	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:200569537T>A	uc010ppk.1	-	12	2686	c.2247A>T	c.(2245-2247)ACA>ACT	p.T749T	KIF14_uc010ppj.1_Silent_p.T258T	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	749	Potential.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCTTAAGGATGTTATTTCTT	0.413													0	0	0	0.01441	0	63	293										A	200569537	T	A	200569537	2	1	80	1	0	0	0	0	0	0	0	1	8276	1451	51	5		5	KIF14	1	200569537	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	14546551	200569537	48681084	25	23913										
HEATR1	55127	broad.mit.edu	37	chr1	236767261	236767261	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aaagatggctcaccaatggcGaaggcggtgtccctgtcgat	13	10	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:236767261G>T	uc001hyd.1	-	2	260	c.135C>A	c.(133-135)TTC>TTA	p.F45L	HEATR1_uc001hye.1_Missense_Mutation_p.F45L	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	45					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CACCAATGGCGAAGGCGGTGT	0.443													1	0	7.45023e-12	0.010504	8.06516e-12	20	29										T	236767261	G	T	236767261	3	4	80	1	0	0	0	0	1	0	0	0	7027	1049	37	3	6475	3	HEATR1	1	236767261	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	36197724	236767261	12483360	26	23914										
OR2L3	391192	broad.mit.edu	37	chr1	248224761	248224761	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cttttgtctacacttatctaCgtccaagatccctgcgatct	5	13	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:248224761C>T	uc001idx.1	+	1	778	c.778C>T	c.(778-780)CGT>TGT	p.R260C	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CACTTATCTACGTCCAAGATC	0.488													0	0	0	0.01441	0	47	118										T	248224761	C	T	248224761	3	4	80	1	0	0	0	0	1	0	0	0	11008	536	19	2	780	2	OR2L3	1	248224761	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	11457500	248224761	1025860	27	23915										
RHOB	388	broad.mit.edu	37	chr2	20647449	20647449	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcctgcggccgctctcctacCcggacaccgacgtcattctc	9	19	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:20647449C>A	uc002rdv.2	+	1	615	c.223C>A	c.(223-225)CCG>ACG	p.P75T		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTCCTACCCGGACACCGA	0.647													1	0	1.37522e-17	0.007413	1.5426e-17	20	113										A	20647449	C	A	20647449	3	1	80	1	0	0	0	0	1	0	0	0	13332	623	22	4	225	4	RHOB	2	20647449	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		20647449	222551924	28	23916										
COMMD1	150684	broad.mit.edu	37	chr2	62227996	62227996	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gagcctcatgaaccagagccGctggaatagcgggcttcggg	15	11	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:62227996G>T	uc002sbp.2	+	2	352	c.341G>T	c.(340-342)CGC>CTC	p.R114L	COMMD1_uc002sbq.1_RNA	NM_152516	NP_689729	Q8N668	COMD1_HUMAN	MURR1	114					copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			ovary(1)	1	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			AACCAGAGCCGCTGGAATAGC	0.502													1	0	5.8336e-16	0.003271	6.45863e-16	36	36										T	62227996	G	T	62227996	3	4	80	1	0	0	0	0	1	0	0	0	3714	1087	38	4	347	4	COMMD1	2	62227996	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	41580547	62227996	180971377	29	23917										
MTHFD2	10797	broad.mit.edu	37	chr2	74432891	74432897	+	Frame_Shift_Del	DEL	GGCAGGA	GGCAGGA	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcagatcaagcaggaagtgcGgcaggaggtagaagagtggg					rs6758485		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:74432891_74432897delGGCAGGA	uc002skk.2	+	2	240_246	c.161_167delGGCAGGA	c.(160-168)CGGCAGGAGfs	p.R54fs	MTHFD2_uc002skj.2_5'UTR|MTHFD2_uc010yro.1_Intron|MTHFD2_uc010ffb.2_Frame_Shift_Del_p.R54fs|MTHFD2_uc010yrp.1_Intron	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	54_56					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAGGAAGTGCGGCAGGAGGTAGAAGAG	0.498																		30	42	---	---								-	74432897	GGCAGGA	-	74432891	7	5	80	1	0	1	0	1	0	0	0	0	9929	1116	39	0	167	0	MTHFD2	2	74432891	Frame_Shift_Del	DEL	GGCAGGA	TCGA-FD-A3SL-01A-21D-A22Z-08	12204895	74432891	168766482	30	23918										
AUP1	550	broad.mit.edu	37	chr2	74754952	74754952	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtgtccctgtctggcccaatTccttggccaccagctaggga	11	14	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:74754952T>C	uc010yrx.1	-	7	1049	c.923A>G	c.(922-924)GAA>GGA	p.E308G	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'UTR|AUP1_uc002smf.2_Missense_Mutation_p.E251G|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.E160G|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	317	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						CTGGCCCAATTCCTTGGCCAC	0.567													0	0	0	0.007291	0	30	149										C	74754952	T	C	74754952	3	2	80	1	0	0	0	0	1	0	0	0	1220	1783	62	5	500	5	AUP1	2	74754952	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	322061	74754952	168444421	31	23919										
LOXL3	84695	broad.mit.edu	37	chr2	74776495	74776495	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccggcgcccgcggcccctcaCctgtagaaggccgcgttgac	13	18	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:74776495C>A	uc002smp.1	-	4	764	c.692_splice	c.e4+1	p.R231_splice	LOXL3_uc002smo.1_Intron|LOXL3_uc010ffm.1_Splice_Site_p.R231_splice|LOXL3_uc002smq.1_Intron|LOXL3_uc010ffn.1_Intron|DOK1_uc002smr.2_Intron	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor							extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						cggccccTCACCTGTAGAAGG	0.567													1	0	0.004672	0.004672	0.00472745	3	9										A	74776495	C	A	74776495	5	1	80	1	0	0	0	0	0	0	1	0	8901	521	18	4	1612	4	LOXL3	2	74776495	Splice_Site	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	21543	74776495	168422878	32	23920										
HK2	3099	broad.mit.edu	37	chr2	75108948	75108948	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agatgcacaacaagatctacGccatcccgcaggaggtcatg	10	12	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:75108948G>T	uc002snd.2	+	11	3607	c.1681G>T	c.(1681-1683)GCC>TCC	p.A561S		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	561	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CAAGATCTACGCCATCCCGCA	0.622													1	0	0.000673444	0.008291	0.00069379	11	11										T	75108948	G	T	75108948	3	4	80	1	0	0	0	0	1	0	0	0	7191	1087	38	4	1723	4	HK2	2	75108948	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	332453	75108948	168090425	33	23921										
DUSP2	1844	broad.mit.edu	37	chr2	96810513	96810513	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tactcacctggtcgtagacaGgagccctggagtcggagcgg	15	11	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:96810513G>A	uc002svk.3	-	2	583	c.497C>T	c.(496-498)CCT>CTT	p.P166L		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	166					endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				GTCGTAGACAGGAGCCCTGGA	0.672													0	0	0	0.00308	0	6	3										A	96810513	G	A	96810513	3	1	80	1	0	0	0	0	1	0	0	0	4819	1000	35	2	459	2	DUSP2	2	96810513	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	21701565	96810513	146388860	34	23922										
ZAP70	7535	broad.mit.edu	37	chr2	98341692	98341692	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gagcgcaaactttactctggGgcgcagaccgacggcaagtt	13	11	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:98341692G>A	uc002syd.1	+	4	747	c.540G>A	c.(538-540)GGG>GGA	p.G180G	ZAP70_uc010yvf.1_Silent_p.G180G|ZAP70_uc002sye.1_Silent_p.G70G	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	180	SH2 2.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						TTTACTCTGGGGCGCAGACCG	0.647													0	0	0	0.001168	0	6	43										A	98341692	G	A	98341692	2	1	80	1	0	0	0	0	0	0	0	1	17511	1219	43	2		2	ZAP70	2	98341692	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1531179	98341692	144857681	35	23923										
GCC2	9648	broad.mit.edu	37	chr2	109092306	109092306	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	caaggagcagaaagctataaGgtaaaaaatagtcattttaa	8	4	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:109092306G>C	uc002tec.2	+	9	3214	c.3060G>C	c.(3058-3060)AAG>AAC	p.K1020N	GCC2_uc002ted.2_Missense_Mutation_p.K919N	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1020	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAAGCTATAAGGTAAAAAATA	0.318													0	0	0	0.009535	0	32	33										C	109092306	G	C	109092306	3	2	80	1	0	0	0	0	1	0	0	0	6286	1014	35	4	3094	4	GCC2	2	109092306	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	10750614	109092306	134107067	36	23924										
TTN	7273	broad.mit.edu	37	chr2	179579734	179579734	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tttgagagcgatggaaccaaCgcaagtgtcgcttcccacat	10	11	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:179579734C>T	uc010zfg.1	-	87	22671	c.22447G>A	c.(22447-22449)GTT>ATT	p.V7483I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V4144I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8410							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGAACCAACGCAAGTGTCG	0.478													0	0	0	0.01441	0	97	77										T	179579734	C	T	179579734	3	4	80	1	0	0	0	0	1	0	0	0	16732	536	19	2	78442	2	TTN	2	179579734	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	70487428	179579734	63619639	37	23925										
CDK15	65061	broad.mit.edu	37	chr2	202687611	202687611	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	accaaagagacactgacattCgtttttgaatacatggtgag	9	7	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:202687611C>G	uc002uyt.2	+	5	577	c.528C>G	c.(526-528)TTC>TTG	p.F176L	CDK15_uc010ftm.2_Missense_Mutation_p.F41L|CDK15_uc002uys.2_Missense_Mutation_p.F125L|CDK15_uc010ftn.1_Missense_Mutation_p.F125L|CDK15_uc010fto.1_Missense_Mutation_p.F176L	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	176	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	CACTGACATTCGTTTTTGAAT	0.343													0	0	0	0.00874	0	39	70										G	202687611	C	G	202687611	3	3	80	1	0	0	0	0	1	0	0	0	3131	883	31	1	389	1	CDK15	2	202687611	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	23107877	202687611	40511762	38	23926										
ANKZF1	55139	broad.mit.edu	37	chr2	220098444	220098444	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctctcttctctaggatgttcGtgacctgctggcagggccaa	11	12	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:220098444G>C	uc002vkg.2	+	8	1001	c.827G>C	c.(826-828)CGT>CCT	p.R276P	ANKZF1_uc010zkv.1_Missense_Mutation_p.R220P|ANKZF1_uc010zkw.1_Missense_Mutation_p.R66P|ANKZF1_uc002vkh.2_Missense_Mutation_p.R66P|ANKZF1_uc002vki.2_Missense_Mutation_p.R276P|ANKZF1_uc002vkj.1_Missense_Mutation_p.R264P	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	276						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGGATGTTCGTGACCTGCTG	0.522													0	0	0	0.01441	0	44	58										C	220098444	G	C	220098444	3	2	80	1	0	0	0	0	1	0	0	0	693	1145	40	4	853	4	ANKZF1	2	220098444	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	17410833	220098444	23100929	39	23927										
GMPPA	29926	broad.mit.edu	37	chr2	220367155	220367155	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcatcgttgagaatccacagAcacacgaggtgagagcagag	13	9	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:220367155A>C	uc002vlr.2	+	6	549	c.481A>C	c.(481-483)ACA>CCA	p.T161P	GMPPA_uc002vls.2_Missense_Mutation_p.T161P|GMPPA_uc002vlt.2_Missense_Mutation_p.T161P|GMPPA_uc002vlu.2_Missense_Mutation_p.T161P|GMPPA_uc002vlv.2_Missense_Mutation_p.T161P|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.T161P	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	161					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		GAATCCACAGACACACGAGGT	0.582													0	0	0	0.010729	0	11	12										C	220367155	A	C	220367155	3	2	80	1	0	0	0	0	1	0	0	0	6494	275	10	5	499	5	GMPPA	2	220367155	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	268711	220367155	22832218	40	23928										
DIS3L2	129563	broad.mit.edu	37	chr2	233075041	233075041	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttcactctttcctagaaaagActgtatcttcaccattgacc	4	12	4	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:233075041A>G	uc010fxz.2	+	10	1406	c.1130A>G	c.(1129-1131)GAC>GGC	p.D377G	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	377							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CCTAGAAAAGACTGTATCTTC	0.428													0	0	0	0.00874	0	41	39										G	233075041	A	G	233075041	3	3	80	1	0	0	0	0	1	0	0	0	4537	275	10	5	1164	5	DIS3L2	2	233075041	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	12707886	233075041	10124332	41	23929										
CHRNG	1146	broad.mit.edu	37	chr2	233409180	233409180	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctacagaatggctcctcggGatggtcgatcacaactgggg	14	10	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:233409180G>T	uc002vsx.1	+	10	1160	c.1139G>T	c.(1138-1140)GGA>GTA	p.G380V	CHRNG_uc010fye.1_Missense_Mutation_p.G328V	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	380	Cytoplasmic (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		GGCTCCTCGGGATGGTCGATC	0.667													1	0	2.17126e-26	0.01441	2.48456e-26	50	64										T	233409180	G	T	233409180	3	4	80	1	0	0	0	0	1	0	0	0	3396	1174	41	3	1177	3	CHRNG	2	233409180	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	334139	233409180	9790193	42	23930										
USP40	55230	broad.mit.edu	37	chr2	234465604	234465604	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaccggaggtcccaactaaaGaagtttccaaagcgctgaag	11	10	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:234465604G>C	uc010zmu.1	-	5	561	c.443C>G	c.(442-444)TCT>TGT	p.S148C	USP40_uc010zmr.1_Missense_Mutation_p.S160C			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	148					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CCCAACTAAAGAAGTTTCCAA	0.428													0	0	0	0.006999	0	41	34										C	234465604	G	C	234465604	3	2	80	1	0	0	0	0	1	0	0	0	17069	942	33	1	3376	1	USP40	2	234465604	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1056424	234465604	8733769	43	23931										
KIF1A	547	broad.mit.edu	37	chr2	241661251	241661251	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcgctggcactgacgcagacGtggctgtgtgtgtactctct	13	11	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:241661251G>A	uc002vzy.2	-	42	4559	c.4413C>T	c.(4411-4413)CAC>CAT	p.H1471H	KIF1A_uc010fzk.2_Silent_p.H1572H|KIF1A_uc002vzw.2_Silent_p.H132H|KIF1A_uc002vzx.2_Silent_p.H198H	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1471					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGACGCAGACGTGGCTGTGTG	0.652													0	0	0	0.001984	0	6	10										A	241661251	G	A	241661251	2	1	80	1	0	0	0	0	0	0	0	1	8283	1136	40	2		2	KIF1A	2	241661251	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	7195647	241661251	1538122	44	23932										
GALNTL2	117248	broad.mit.edu	37	chr3	16217067	16217067	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccccaaagagggactgggggGctgatgaggacggggaggtg	21	7	0	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:16217067G>A	uc003car.3	+	1	884	c.409G>A	c.(409-411)GCT>ACT	p.A137T	GALNTL2_uc003caq.3_Intron	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	137	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GGACTGGGGGGCTGATGAGGA	0.637													0	0	0	0.00245	0	14	55										A	16217067	G	A	16217067	3	1	80	1	0	0	0	0	1	0	0	0	6222	1203	42	2	411	2	GALNTL2	3	16217067	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		16217067	181805363	45	23933										
WDR6	11180	broad.mit.edu	37	chr3	49051011	49051011	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aggatggggatgtcatgctgTacagggctctgggtggctgc	18	7	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:49051011T>A	uc003cvj.2	+	2	2272	c.2134T>A	c.(2134-2136)TAC>AAC	p.Y712N	WDR6_uc011bbx.1_3'UTR|WDR6_uc011bby.1_Missense_Mutation_p.Y160N|WDR6_uc010hkn.2_Missense_Mutation_p.Y656N|WDR6_uc011bbz.1_Missense_Mutation_p.Y631N	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	682	WD 11.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGTCATGCTGTACAGGGCTCT	0.587											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	18	36										A	49051011	T	A	49051011	3	1	80	1	0	0	0	0	1	0	0	0	17307	1638	57	5	2140	5	WDR6	3	49051011	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	32833944	49051011	148971419	46	23934										
ZNF654	55279	broad.mit.edu	37	chr3	88189288	88189288	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgtttgcattttaattgcaaCgagtcgtttaagctgccgtt	9	7	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:88189288C>G	uc003dqv.2	+	1	1027	c.828C>G	c.(826-828)AAC>AAG	p.N276K	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	276	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TTAATTGCAACGAGTCGTTTA	0.373													0	0	0	0.013114	0	46	71										G	88189288	C	G	88189288	3	3	80	1	0	0	0	0	1	0	0	0	18064	535	19	4	830	4	ZNF654	3	88189288	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	39138277	88189288	109833142	47	23935										
TRAT1	50852	broad.mit.edu	37	chr3	108572572	108572572	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atttctcagacaaggatggaGatgagcaactacatgcaata	9	7	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:108572572G>T	uc003dxi.1	+	6	553	c.409G>T	c.(409-411)GAT>TAT	p.D137Y	TRAT1_uc010hpx.1_Missense_Mutation_p.D100Y	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	137	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CAAGGATGGAGATGAGCAACT	0.453													1	0	2.41591e-17	0.004656	2.69224e-17	28	99										T	108572572	G	T	108572572	3	4	80	1	0	0	0	0	1	0	0	0	16463	942	33	3	431	3	TRAT1	3	108572572	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	20383284	108572572	89449858	48	23936										
TAGLN3	29114	broad.mit.edu	37	chr3	111718304	111718304	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cccgagctatggcttaagccGagaggtgcaggagaagatcg	15	9	0	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:111718304G>A	uc003dym.2	+	2	413	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	TAGLN3_uc003dyl.2_Missense_Mutation_p.R12Q|TAGLN3_uc003dyn.2_Missense_Mutation_p.R12Q|TAGLN3_uc003dyo.2_Missense_Mutation_p.R12Q	NM_001008272	NP_001008273	Q9UI15	TAGL3_HUMAN	transgelin 3	12					central nervous system development|muscle organ development						0						GGCTTAAGCCGAGAGGTGCAG	0.587													0	0	0	0.001855	0	13	61										A	111718304	G	A	111718304	3	1	80	1	0	0	0	0	1	0	0	0	15537	1058	37	1	37	1	TAGLN3	3	111718304	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3145732	111718304	86304126	49	23937										
PARP14	54625	broad.mit.edu	37	chr3	122399790	122399790	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcctggggccccgaccccccGaagaacttgaacaccaagtt	9	16	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:122399790G>T	uc003efq.3	+	1	119	c.60G>T	c.(58-60)CCG>CCT	p.P20P		NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CCGACCCCCCGAAGAACTTGA	0.682													1	0	1.06961e-07	0.00308	1.13626e-07	6	15										T	122399790	G	T	122399790	2	4	80	1	0	0	0	0	0	0	0	1	11458	1045	37	3		3	PARP14	3	122399790	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	10681486	122399790	75622640	50	23938										
ZXDC	79364	broad.mit.edu	37	chr3	126191141	126191141	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctcactgtgataaatgtcttCtcacagcctgaacaaggaaa	7	10	3	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:126191141C>G	uc003eiv.2	-	2	969	c.915G>C	c.(913-915)GAG>GAC	p.E305D	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.E305D	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	305	C2H2-type 5.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		TAAATGTCTTCTCACAGCCTG	0.478													0	0	0	0.005524	0	36	75										G	126191141	C	G	126191141	3	3	80	1	0	0	0	0	1	0	0	0	18249	912	32	1	1703	1	ZXDC	3	126191141	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	3791351	126191141	71831289	51	23939										
COL6A6	131873	broad.mit.edu	37	chr3	130282263	130282263	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cccaattctagtggtcctggCttcatctgagtctgaggata	10	10	4	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:130282263C>T	uc010htl.2	+	2	447	c.416C>T	c.(415-417)GCT>GTT	p.A139V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	139	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GTGGTCCTGGCTTCATCTGAG	0.493													0	0	0	0.010818	0	33	38										T	130282263	C	T	130282263	3	4	80	1	0	0	0	0	1	0	0	0	3703	797	28	2	422	2	COL6A6	3	130282263	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4091122	130282263	67740167	52	23940										
GNB4	59345	broad.mit.edu	37	chr3	179131259	179131259	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctgtctacacattccatctcGaatatcccataatttggaag	5	11	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:179131259G>C	uc003fjv.3	-	8	920	c.640C>G	c.(640-642)CGA>GGA	p.R214G	GNB4_uc003fju.3_Missense_Mutation_p.R125G	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	214	WD 4.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			ATTCCATCTCGAATATCCCAT	0.398													0	0	0	0.00632	0	27	99										C	179131259	G	C	179131259	3	2	80	1	0	0	0	0	1	0	0	0	6520	1066	37	1	394	1	GNB4	3	179131259	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	48848996	179131259	18891171	53	23941										
EIF4A2	1974	broad.mit.edu	37	chr3	186503971	186503974	+	Frame_Shift_Del	DEL	TGTT	TGTT	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agctccaaaatggatcaaaaTgtttgttttggatgaagcag							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:186503971_186503974delTGTT	uc003fqs.2	+	6	575_578	c.536_539delTGTT	c.(535-540)ATGTTTfs	p.M179fs	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Frame_Shift_Del_p.M180fs|EIF4A2_uc003fqv.2_Frame_Shift_Del_p.M84fs|EIF4A2_uc003fqw.2_Frame_Shift_Del_p.M84fs|EIF4A2_uc011bsb.1_Frame_Shift_Del_p.M52fs|MIR1248_hsa-mir-1248|MI0006383_5'Flank|SNORA81_uc010hyv.1_5'Flank|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	179_180	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TGGATCAAAATGTTTGTTTTGGAT	0.319			T	BCL6	NHL													40	46	---	---								-	186503974	TGTT	-	186503971	7	5	80	1	0	1	0	1	0	0	0	0	5025	1464	51	0	558	0	EIF4A2	3	186503971	Frame_Shift_Del	DEL	TGTT	TCGA-FD-A3SL-01A-21D-A22Z-08	7372712	186503971	11518459	54	23942										
ST6GAL1	6480	broad.mit.edu	37	chr3	186793484	186793484	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cgatgggtgcctaccacccgCtgctctatgagaagaatttg	11	11	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:186793484C>T	uc003frb.2	+	8	1546	c.1114C>T	c.(1114-1116)CTG>TTG	p.L372L	ST6GAL1_uc003frc.2_Silent_p.L141L|ST6GAL1_uc003frd.2_Silent_p.L372L	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	372	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CTACCACCCGCTGCTCTATGA	0.512													0	0	0	0.001168	0	6	76										T	186793484	C	T	186793484	2	4	80	1	0	0	0	0	0	0	0	1	15220	796	28	2		2	ST6GAL1	3	186793484	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	289513	186793484	11228946	55	23943										
UCHL1	7345	broad.mit.edu	37	chr4	41259007	41259007	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cgcgaagatgcagctcaagcCgatggagatcaaccccgagg	13	12	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:41259007C>G	uc003gvo.2	+	1	110	c.14C>G	c.(13-15)CCG>CGG	p.P5R	UCHL1_uc003gvp.2_5'UTR|UCHL1_uc003gvq.2_5'UTR|UCHL1_uc003gvr.2_5'UTR	NM_004181	NP_004172	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1	5	Interaction with ubiquitin.				cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|skin(1)	2						CAGCTCAAGCCGATGGAGATC	0.652													0	0	0	0.00333	0	22	45										G	41259007	C	G	41259007	3	3	80	1	0	0	0	0	1	0	0	0	16917	652	23	4	16	4	UCHL1	4	41259007	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		41259007	149895269	56	23944										
TET2	54790	broad.mit.edu	37	chr4	106158065	106158065	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtggaacctggatgcaagcCacatgcctgtatgcacacag	12	11	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:106158065C>T	uc003hxk.2	+	3	3352	c.2966C>T	c.(2965-2967)CCA>CTA	p.P989L	TET2_uc011cez.1_Missense_Mutation_p.P1010L|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.P989L|TET2_uc003hxi.1_Missense_Mutation_p.P989L	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	989					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		GGATGCAAGCCACATGCCTGT	0.463			Mis N|F		MDS								0	0	0	0.00632	0	29	25										T	106158065	C	T	106158065	3	4	80	1	0	0	0	0	1	0	0	0	15767	594	21	2	2968	2	TET2	4	106158065	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	64899058	106158065	84996211	57	23945										
NPY2R	4887	broad.mit.edu	37	chr4	156136030	156136030	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttcacagtgttccacatcatCgccatgtgctccacttttgc	6	14	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:156136030C>T	uc003ioq.2	+	2	1434	c.939C>T	c.(937-939)ATC>ATT	p.I313I	NPY2R_uc003ior.2_Silent_p.I313I	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	313	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				TCCACATCATCGCCATGTGCT	0.542													0	0	0	0.010504	0	22	38										T	156136030	C	T	156136030	2	4	80	1	0	0	0	0	0	0	0	1	10609	874	31	1		1	NPY2R	4	156136030	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	49977965	156136030	35018246	58	23946										
ETFDH	2110	broad.mit.edu	37	chr4	159593615	159593615	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tggtgactttgaacatgctgGtgccgctagccaagctgtcc	12	11	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:159593615G>T	uc003iqb.2	+	1	339	c.7G>T	c.(7-9)GTG>TTG	p.V3L	C4orf46_uc003iqa.2_5'Flank|C4orf46_uc010iqp.1_5'Flank|ETFDH_uc010iqq.2_RNA|ETFDH_uc011cjg.1_Missense_Mutation_p.V3L|ETFDH_uc010iqr.2_5'UTR	NM_004453	NP_004444	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	3					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		GAACATGCTGGTGCCGCTAGC	0.652											OREG0016379	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.04996e-18	0.012319	9.05952e-18	19	42										T	159593615	G	T	159593615	3	4	80	1	0	0	0	0	1	0	0	0	5271	1261	44	4	9	4	ETFDH	4	159593615	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3457585	159593615	31560661	59	23947										
SDHA	6389	broad.mit.edu	37	chr5	240522	240522	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctggggaagaatctgtcatGaatcttgacaaattgagatt	11	5	3	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:240522G>A	uc003jao.3	+	11	1597	c.1482G>A	c.(1480-1482)ATG>ATA	p.M494I	SDHA_uc011clv.1_Missense_Mutation_p.M494I|SDHA_uc011clw.1_Missense_Mutation_p.M446I|SDHA_uc003jap.3_Missense_Mutation_p.M494I|SDHA_uc003jaq.3_Missense_Mutation_p.M269I|SDHA_uc003jar.3_Missense_Mutation_p.M88I	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	494					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	AATCTGTCATGAATCTTGACA	0.398									Familial_Paragangliomas				0	0	0	0.004007	0	14	48										A	240522	G	A	240522	3	1	80	1	0	0	0	0	1	0	0	0	13963	1290	45	1	1524	1	SDHA	5	240522	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		240522	180674738	60	23948										
PAPD7	11044	broad.mit.edu	37	chr5	6750553	6750553	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttgactttgtcgctgtccagCccccagctcctgtcttcagg	9	15	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:6750553C>T	uc003jdx.1	+	10	1176	c.1047C>T	c.(1045-1047)AGC>AGT	p.S349S	PAPD7_uc011cmn.1_Silent_p.S340S|PAPD7_uc010itl.1_Silent_p.S169S	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	349	Ser-rich.				cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						CGCTGTCCAGCCCCCAGCTCC	0.572													0	0	0	0.007413	0	20	33										T	6750553	C	T	6750553	2	4	80	1	0	0	0	0	0	0	0	1	11426	738	26	2		2	PAPD7	5	6750553	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	6510031	6750553	174164707	61	23949										
CCT5	22948	broad.mit.edu	37	chr5	10254792	10254792	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acgttgttttttagggcttgAtaagatgatggtggataagg	14	2	0	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:10254792A>T	uc003jeq.2	+	3	344	c.173A>T	c.(172-174)GAT>GTT	p.D58V	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Missense_Mutation_p.D58V|CCT5_uc010its.2_Missense_Mutation_p.D58V|CCT5_uc011cmr.1_Intron|CCT5_uc011cms.1_Missense_Mutation_p.D20V|CCT5_uc011cmt.1_Intron	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	58					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						TTAGGGCTTGATAAGATGATG	0.418													0	0	0	0.012319	0	19	74										T	10254792	A	T	10254792	3	4	80	1	0	0	0	0	1	0	0	0	2956	333	12	5	183	5	CCT5	5	10254792	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	3504239	10254792	170660468	62	23950										
C5orf51	285636	broad.mit.edu	37	chr5	41917223	41917223	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	accagaaaatcatgaagtggAtactagtgtgtctggagcgg	13	6	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:41917223A>G	uc003jmo.2	+	6	707	c.707A>G	c.(706-708)GAT>GGT	p.D236G		NM_175921	NP_787117	A6NDU8	CE051_HUMAN	hypothetical protein LOC285636	236											0						CATGAAGTGGATACTAGTGTG	0.418													0	0	0	0.012213	0	33	61										G	41917223	A	G	41917223	3	3	80	1	0	0	0	0	1	0	0	0	2308	333	12	5	729	5	C5orf51	5	41917223	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	31662431	41917223	138998037	63	23951										
MAP3K1	4214	broad.mit.edu	37	chr5	56181840	56181840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctacactgaacagttactccGtggcctttcgtatctccatg	7	13	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:56181840G>A	uc003jqw.3	+	17	4565	c.4064G>A	c.(4063-4065)CGT>CAT	p.R1355H		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1355	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAGTTACTCCGTGGCCTTTCG	0.338													0	0	0	0.007291	0	25	43										A	56181840	G	A	56181840	3	1	80	1	0	0	0	0	1	0	0	0	9243	1145	40	2	4130	2	MAP3K1	5	56181840	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	14264617	56181840	124733420	64	23952										
MEF2C	4208	broad.mit.edu	37	chr5	88018629	88018629	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgtgttgtgggtatctcgaaGgggtggtggtacggtctcta	17	5	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:88018629G>C	uc003kjj.2	-	11	1887	c.1214C>G	c.(1213-1215)CCT>CGT	p.P405R	MEF2C_uc003kji.2_Missense_Mutation_p.P397R|MEF2C_uc003kjk.2_Missense_Mutation_p.P405R|MEF2C_uc003kjm.2_Missense_Mutation_p.P395R|MEF2C_uc003kjl.2_Missense_Mutation_p.P415R	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	405					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		GTATCTCGAAGGGGTGGTGGT	0.532										HNSCC(66;0.2)			0	0	0	0.00245	0	14	31										C	88018629	G	C	88018629	3	2	80	1	0	0	0	0	1	0	0	0	9457	1000	35	4	211	4	MEF2C	5	88018629	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	31836789	88018629	92896631	65	23953										
SNCAIP	9627	broad.mit.edu	37	chr5	121786478	121786478	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccttggaattccaggatgctCaggcttcctctagaaattct	8	11	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:121786478C>T	uc003ksw.1	+	10	2142	c.1936C>T	c.(1936-1938)CAG>TAG	p.Q646*	SNCAIP_uc011cwl.1_Nonsense_Mutation_p.Q204*|SNCAIP_uc003ksx.1_Nonsense_Mutation_p.Q693*|SNCAIP_uc003ksy.1_Nonsense_Mutation_p.Q280*|SNCAIP_uc003ksz.1_Nonsense_Mutation_p.Q280*|SNCAIP_uc010jcu.2_Nonsense_Mutation_p.Q242*|SNCAIP_uc011cwm.1_Nonsense_Mutation_p.Q280*|SNCAIP_uc003kta.1_Nonsense_Mutation_p.Q278*|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Nonsense_Mutation_p.Q340*|SNCAIP_uc010jcx.1_Nonsense_Mutation_p.Q586*|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Nonsense_Mutation_p.Q162*	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	646					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CCAGGATGCTCAGGCTTCCTC	0.443													0	0	0	0.006214	0	10	47										T	121786478	C	T	121786478	4	4	80	1	0	0	0	0	0	1	0	0	14841	827	29	1	1970	1	SNCAIP	5	121786478	Nonsense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	33767849	121786478	59128782	66	23954										
RAPGEF6	51735	broad.mit.edu	37	chr5	130799891	130799891	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aacagcatgaaaaactacttCtttagctgtggtgtctttac	7	8	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:130799891C>T	uc003kvn.1	-	18	2529	c.2323G>A	c.(2323-2325)GAA>AAA	p.E775K	RAPGEF6_uc003kvp.1_Missense_Mutation_p.E825K|RAPGEF6_uc003kvo.1_Missense_Mutation_p.E780K|RAPGEF6_uc010jdi.1_Missense_Mutation_p.E775K|RAPGEF6_uc010jdj.1_Missense_Mutation_p.E775K|RAPGEF6_uc003kvq.2_Missense_Mutation_p.E492K|RAPGEF6_uc003kvr.2_Missense_Mutation_p.E775K|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.E775K	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	775	Ras-associating.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AAAACTACTTCTTTAGCTGTG	0.368													0	0	0	0.014323	0	23	30										T	130799891	C	T	130799891	3	4	80	1	0	0	0	0	1	0	0	0	13048	922	32	1	2993	1	RAPGEF6	5	130799891	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	9013413	130799891	50115369	67	23955										
DDX46	9879	broad.mit.edu	37	chr5	134143532	134143532	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tctgttgctgcccgaggtctAgatgtgaaacatctgattct	10	9	4	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:134143532A>C	uc003kzw.2	+	16	2217	c.2049A>C	c.(2047-2049)CTA>CTC	p.L683L	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	683	Helicase C-terminal.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCCGAGGTCTAGATGTGAAAC	0.438													0	0	0	0.014323	0	22	37										C	134143532	A	C	134143532	2	2	80	1	0	0	0	0	0	0	0	1	4364	407	15	5		5	DDX46	5	134143532	Silent	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	3343641	134143532	46771728	68	23956										
FAM13B	51306	broad.mit.edu	37	chr5	137278576	137278576	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atacatacatagaagctgctCgagaacttgacaatcggaga	9	8	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:137278576C>G	uc003lbz.2	-	21	3044	c.2510G>C	c.(2509-2511)CGA>CCA	p.R837P	FAM13B_uc003lcb.2_Missense_Mutation_p.R713P|FAM13B_uc003lca.2_Missense_Mutation_p.R809P	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	837					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						AGAAGCTGCTCGAGAACTTGA	0.323													0	0	0	0.003271	0	35	43										G	137278576	C	G	137278576	3	3	80	1	0	0	0	0	1	0	0	0	5453	884	31	1	249	1	FAM13B	5	137278576	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	3135044	137278576	43636684	69	23957										
PCDHA11	56138	broad.mit.edu	37	chr5	140249821	140249821	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagcgtgtctgaccgtgactCaggtgtcaacggacaggtga	14	10	3	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:140249821C>G	uc003lia.2	+	1	1991	c.1133C>G	c.(1132-1134)TCA>TGA	p.S378*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Nonsense_Mutation_p.S378*	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	378	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCGTGACTCAGGTGTCAAC	0.587													0	0	0	0.00499	0	18	72										G	140249821	C	G	140249821	4	3	80	1	0	0	0	0	0	1	0	0	11521	838	29	1	1135	1	PCDHA11	5	140249821	Nonsense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	2971245	140249821	40665439	70	23958										
ARHGEF37	389337	broad.mit.edu	37	chr5	149011634	149011634	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	accatcctggaggcccaggaCaagaaggggaaccctgagtg	14	11	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:149011634C>A	uc003lra.1	+	13	1972	c.1908C>A	c.(1906-1908)GAC>GAA	p.D636E		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	636	SH3 2.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						AGGCCCAGGACAAGAAGGGGA	0.592													1	0	0.00198382	0.001984	0.00201935	7	50										A	149011634	C	A	149011634	3	1	80	1	0	0	0	0	1	0	0	0	906	477	17	4	1954	4	ARHGEF37	5	149011634	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	8761813	149011634	31903626	71	23959										
SLC36A3	285641	broad.mit.edu	37	chr5	150660726	150660726	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atgccgatagagtacatcagCttgactgactggtacaacct	9	10	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:150660726C>T	uc003ltw.2	-	9	1412	c.993G>A	c.(991-993)AAG>AAA	p.K331K	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.K316K|SLC36A3_uc003ltx.2_Silent_p.K372K	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	331	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTACATCAGCTTGACTGACT	0.517													0	0	0	0.006214	0	8	60										T	150660726	C	T	150660726	2	4	80	1	0	0	0	0	0	0	0	1	14595	796	28	2		2	SLC36A3	5	150660726	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1649092	150660726	30254534	72	23960										
CYFIP2	26999	broad.mit.edu	37	chr5	156714072	156714072	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gacaggaatgcatttgtcacGggcattgcaaggtacattga	12	7	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:156714072G>T	uc003lwq.2	+	3	300	c.162G>T	c.(160-162)ACG>ACT	p.T54T	CYFIP2_uc011ddn.1_Silent_p.T54T|CYFIP2_uc011ddo.1_Silent_p.T54T|CYFIP2_uc003lwr.2_Silent_p.T54T|CYFIP2_uc003lws.2_Silent_p.T54T|CYFIP2_uc003lwp.2_5'UTR	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	54					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATTTGTCACGGGCATTGCAA	0.502													1	0	2.56e-06	0.009096	2.67779e-06	3	29										T	156714072	G	T	156714072	2	4	80	1	0	0	0	0	0	0	0	1	4138	1103	39	4		4	CYFIP2	5	156714072	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	6053346	156714072	24201188	73	23961										
GABRA6	2559	broad.mit.edu	37	chr5	161128777	161128777	+	Nonstop_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aagtcagtagcagtgttgaaTagcttgcggccaggacaacc	12	9	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:161128777T>A	uc003lyu.2	+	9	1698	c.1360T>A	c.(1360-1362)TAG>AAG	p.*454K	GABRA6_uc003lyv.2_Nonstop_Mutation_p.*225K	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	454					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGTGTTGAATAGCTTGCGGC	0.383										TCGA Ovarian(5;0.080)			0	0	0	0.003163	0	14	68										A	161128777	T	A	161128777	4	1	80	1	0	0	0	0	0	0	0	0	6165	1419	49	5	1394	5	GABRA6	5	161128777	Nonstop_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	4414705	161128777	19786483	74	23962										
TLX3	30012	broad.mit.edu	37	chr5	170737358	170737358	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cctcaaaatgacggacgcgcAggtcaagacctggttccaaa	10	12	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:170737358A>T	uc003mbf.2	+	2	708	c.626A>T	c.(625-627)CAG>CTG	p.Q209L	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	209	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ACGGACGCGCAGGTCAAGACC	0.642			T	BCL11B	T-ALL								0	0	0	0.009096	0	3	15										T	170737358	A	T	170737358	3	4	80	1	0	0	0	0	1	0	0	0	15959	188	7	5	632	5	TLX3	5	170737358	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	9608581	170737358	10177902	75	23963										
FOXC1	2296	broad.mit.edu	37	chr6	1610867	1610867	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acccgggcggcatggcccgcGcctacgggccctacacgccg	14	19	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:1610867G>A	uc003mtp.2	+	1	187	c.187G>A	c.(187-189)GCC>ACC	p.A63T		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	63					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		CATGGCCCGCGCCTACGGGCC	0.612													0	0	0	0.009096	0	4	44										A	1610867	G	A	1610867	3	1	80	1	0	0	0	0	1	0	0	0	5994	1087	38	2	189	2	FOXC1	6	1610867	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		1610867	169504200	76	23964										
TFAP2A	7020	broad.mit.edu	37	chr6	10400738	10400738	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cattgggatcggaatgttgtCggttgagaaattcagctact	12	6	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:10400738C>G	uc003myr.2	-	6	1220	c.968G>C	c.(967-969)CGA>CCA	p.R323P	TFAP2A_uc003myq.2_Missense_Mutation_p.R317P|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Intron|TFAP2A_uc003myt.2_Missense_Mutation_p.R319P	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	323	H-S-H (helix-span-helix), dimerization.				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				GGAATGTTGTCGGTTGAGAAA	0.488													0	0	0	0.00333	0	24	62										G	10400738	C	G	10400738	3	3	80	1	0	0	0	0	1	0	0	0	15784	884	31	1	353	1	TFAP2A	6	10400738	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	8789871	10400738	160714329	77	23965										
MICA	4276	broad.mit.edu	37	chr6	31378395	31378395	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtcagggtttcttgctgaggTacatctggatggtcagccct	13	9	4	1	rs17200158		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:31378395T>C	uc003ntk.1	+	2	185	c.146T>C	c.(145-147)GTA>GCA	p.V49A	MICA_uc003rxz.1_5'UTR					RecName: Full=MHC class I polypeptide-related sequence A;          Short=MIC-A; Flags: Precursor;												0		Ovarian(999;0.0253)				CTTGCTGAGGTACATCTGGAT	0.542													0	0	0	0.000602	0	5	23										C	31378395	T	C	31378395	3	2	80	1	0	0	0	0	1	0	0	0	9568	1638	57	5	152	5	MICA	6	31378395	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	20977657	31378395	139736672	78	23966										
C6orf27	80737	broad.mit.edu	37	chr6	31733543	31733543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agccggtaggggtggtgtgcCggtcctgtggggaaaaggaa	20	6	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:31733543C>T	uc011dog.1	-	17	2742	c.2504G>A	c.(2503-2505)CGG>CAG	p.R835Q		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	835						extracellular region		p.R835Q(1)		ovary(3)	3						GGTGGTGTGCCGGTCCTGTGG	0.597													0	0	0	0.004672	0	3	34										T	31733543	C	T	31733543	3	4	80	1	0	0	0	0	1	0	0	0	2362	652	23	2	174	2	C6orf27	6	31733543	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	355148	31733543	139381524	79	23967										
AGPAT1	10554	broad.mit.edu	37	chr6	32138226	32138226	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgggtgagcagggtctgggcGacctcagacatgacactgat	15	9	2	4	rs141411867		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:32138226G>A	uc003oae.2	-	4	804	c.486C>T	c.(484-486)GTC>GTT	p.V162V	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Silent_p.V126V|AGPAT1_uc003oaf.2_Silent_p.V162V|AGPAT1_uc003oag.2_Intron|AGPAT1_uc003oah.2_Silent_p.V162V|AGPAT1_uc003oai.1_Silent_p.V162V|AGPAT1_uc011dpl.1_Silent_p.V50V	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	162					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						GGGTCTGGGCGACCTCAGACA	0.582													0	0	0	0.00632	0	28	45										A	32138226	G	A	32138226	2	1	80	1	0	0	0	0	0	0	0	1	386	1045	37	1		1	AGPAT1	6	32138226	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	404683	32138226	138976841	80	23968										
PACSIN1	29993	broad.mit.edu	37	chr6	34494142	34494143	+	Nonsense_Mutation	DNP	GG	GG	CT													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gagaccaccgacagcttctgGgaggtgaggctctcatgatc							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:34494142_34494143GG>CT	uc003ojo.2	+	2	266_267	c.60_61GG>CT	c.(58-63)TGGGAG>TGCTAG	p.20_21WE>C*	PACSIN1_uc003ojp.2_Nonsense_Mutation_p.20_21WE>C*	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	20_21	FCH.				endocytosis		protein kinase activity				0						ACAGCTTCTGGGAGGTGAGGCT	0.629													0	0	0	0.004672	0	8	26										CT	34494143	GG	CT	34494142	4	2	80	1	0	0	0	0	0	1	0	0	11374	1241	43	4	62	4	PACSIN1	6	34494142	Nonsense_Mutation	DNP	GG	TCGA-FD-A3SL-01A-21D-A22Z-08	2355916	34494142	136620925	81	23969										
PHF3	23469	broad.mit.edu	37	chr6	64408130	64408130	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	taggtactcatgagaagcaaGagatgaaaaagaagaaagtt	11	3	1	5			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:64408130G>C	uc003pep.1	+	6	2724	c.2698G>C	c.(2698-2700)GAG>CAG	p.E900Q	PHF3_uc010kag.1_Missense_Mutation_p.E812Q|PHF3_uc010kah.1_Missense_Mutation_p.E714Q|PHF3_uc003pen.2_Missense_Mutation_p.E812Q|PHF3_uc011dxs.1_Missense_Mutation_p.E169Q	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	900					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TGAGAAGCAAGAGATGAAAAA	0.333													0	0	0	0.008361	0	28	58										C	64408130	G	C	64408130	3	2	80	1	0	0	0	0	1	0	0	0	11836	943	33	1	2720	1	PHF3	6	64408130	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	29913988	64408130	106706937	82	23970										
DOPEY1	23033	broad.mit.edu	37	chr6	83848597	83848597	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggttttgattttgttgtatcTgacttagaacacatcagtcc	8	7	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:83848597T>A	uc003pjs.1	+	21	5096	c.4836T>A	c.(4834-4836)TCT>TCA	p.S1612S	DOPEY1_uc011dyy.1_Silent_p.S1603S|DOPEY1_uc010kbl.1_Silent_p.S1603S|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1612					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTGTTGTATCTGACTTAGAAC	0.413													0	0	0	0.008361	0	31	47										A	83848597	T	A	83848597	2	1	80	1	0	0	0	0	0	0	0	1	4707	1567	55	5		5	DOPEY1	6	83848597	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	19440467	83848597	87266470	83	23971										
C6orf170	221322	broad.mit.edu	37	chr6	121577357	121577357	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	taaccacaggcaacatttctGatccagaaaatatagaaata	5	8	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:121577357G>C	uc003pyo.1	-	16	1876	c.1808C>G	c.(1807-1809)TCA>TGA	p.S603*	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Nonsense_Mutation_p.S122*	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	603					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		CAACATTTCTGATCCAGAAAA	0.343													0	0	0	0.006122	0	18	32										C	121577357	G	C	121577357	4	2	80	1	0	0	0	0	0	1	0	0	2344	1294	45	1	2033	1	C6orf170	6	121577357	Nonsense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	37728760	121577357	49537710	84	23972										
C7orf28B	221960	broad.mit.edu	37	chr7	6862992	6862992	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	accgagctataaaccttgtcCtgcagacgcgaaaacacagc	8	13	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:6862992C>A	uc003sqx.1	-	5	424	c.391_splice	c.e5-1	p.D131_splice	C7orf28B_uc011jxd.1_Splice_Site|C7orf28B_uc003sqy.1_3'UTR	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960							lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		AAACCTTGTCCTGCAGACGCG	0.478													1	0	1.06961e-07	0.00308	1.13626e-07	5	37										A	6862992	C	A	6862992	5	1	80	1	0	0	0	0	0	0	1	0	2384	695	24	4	1102	4	C7orf28B	7	6862992	Splice_Site	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		6862992	152275671	85	23973										
BAZ1B	9031	broad.mit.edu	37	chr7	72883944	72883944	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgtacccagcctttttcaatGaataatcctggaacttcatc	5	11	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:72883944G>A	uc003tyc.2	-	9	3114	c.2769C>T	c.(2767-2769)TTC>TTT	p.F923F		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	923					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTTTTTCAATGAATAATCCTG	0.418													0	0	0	0.003163	0	16	56										A	72883944	G	A	72883944	2	1	80	1	0	0	0	0	0	0	0	1	1330	1281	45	1		1	BAZ1B	7	72883944	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	66020952	72883944	86254719	86	23974										
SEMA3A	10371	broad.mit.edu	37	chr7	83758479	83758479	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acttgcattcatctcttctgGtgtaagatactggccacaca	7	11	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:83758479G>T	uc003uhz.2	-	3	608	c.293C>A	c.(292-294)ACC>AAC	p.T98N		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	98	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATCTCTTCTGGTGTAAGATAC	0.299													1	0	1.75199e-13	0.007291	1.92099e-13	24	78										T	83758479	G	T	83758479	3	4	80	1	0	0	0	0	1	0	0	0	14024	1261	44	4	2082	4	SEMA3A	7	83758479	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	10874535	83758479	75380184	87	23975										
SEMA3D	223117	broad.mit.edu	37	chr7	84628794	84628794	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agggagctcatccaggtctcTgtgatgtcttcgatttcgtt	11	9	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:84628794T>C	uc003uic.2	-	17	2336	c.2296A>G	c.(2296-2298)AGA>GGA	p.R766G	SEMA3D_uc010led.2_Missense_Mutation_p.R766G|SEMA3D_uc003uib.2_Missense_Mutation_p.R405G	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	766	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TCCAGGTCTCTGTGATGTCTT	0.433													0	0	0	0.00333	0	25	51										C	84628794	T	C	84628794	3	2	80	1	0	0	0	0	1	0	0	0	14027	1588	55	5	41	5	SEMA3D	7	84628794	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	870315	84628794	74509869	88	23976										
SAMD9	54809	broad.mit.edu	37	chr7	92732105	92732105	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcttgttttgcccagtttagAgcattgccaaagtccttctt	8	10	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:92732105A>G	uc003umf.2	-	3	3562	c.3306T>C	c.(3304-3306)GCT>GCC	p.A1102A	SAMD9_uc003umg.2_Silent_p.A1102A	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1102						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CCCAGTTTAGAGCATTGCCAA	0.373													0	0	0	0.003271	0	35	111										G	92732105	A	G	92732105	2	3	80	1	0	0	0	0	0	0	0	1	13826	291	11	5		5	SAMD9	7	92732105	Silent	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	8103311	92732105	66406558	89	23977										
MLL5	55904	broad.mit.edu	37	chr7	104752743	104752743	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagccaatactcagcaggcaActtctggaacattatttaca	6	11	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:104752743A>C	uc003vcm.2	+	27	5074	c.4540A>C	c.(4540-4542)ACT>CCT	p.T1514P	MLL5_uc010ljc.2_Missense_Mutation_p.T1514P|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.T248P	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1514	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TCAGCAGGCAACTTCTGGAAC	0.473													0	0	0	0.00632	0	28	57										C	104752743	A	C	104752743	3	2	80	1	0	0	0	0	1	0	0	0	9624	43	2	5	4638	5	MLL5	7	104752743	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	12020638	104752743	54385920	90	23978										
FLNC	2318	broad.mit.edu	37	chr7	128484781	128484781	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cgccattctccatcgacaccAagggggctggcacaggtggc	13	14	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:128484781A>T	uc003vnz.3	+	21	3471	c.3262A>T	c.(3262-3264)AAG>TAG	p.K1088*	FLNC_uc003voa.3_Nonsense_Mutation_p.K1088*	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1088	Filamin 9.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CATCGACACCAAGGGGGCTGG	0.632													0	0	0	0.007413	0	19	54										T	128484781	A	T	128484781	4	4	80	1	0	0	0	0	0	1	0	0	5935	131	5	5	3344	5	FLNC	7	128484781	Nonsense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	23732038	128484781	30653882	91	23979										
AHCYL2	23382	broad.mit.edu	37	chr7	129062699	129062699	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aggcgagtctgcggacaccaGaactgacctgggagcgagtg	16	10	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:129062699G>A	uc011kov.1	+	13	1534	c.1480G>A	c.(1480-1482)GAA>AAA	p.E494K	AHCYL2_uc003vot.2_Missense_Mutation_p.E493K|AHCYL2_uc003vov.2_Missense_Mutation_p.E391K|AHCYL2_uc011kow.1_Missense_Mutation_p.E392K|AHCYL2_uc011kox.1_Missense_Mutation_p.E391K	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	494					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GCGGACACCAGAACTGACCTG	0.512													0	0	0	0.00499	0	15	57										A	129062699	G	A	129062699	3	1	80	1	0	0	0	0	1	0	0	0	411	943	33	1	1652	1	AHCYL2	7	129062699	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	577918	129062699	30075964	92	23980										
ZC3HC1	51530	broad.mit.edu	37	chr7	129663417	129663417	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gggctagatggtacctccagGccaggggtgtctcctgttcc	14	12	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:129663417G>C	uc003vpi.2	-	8	1194	c.1167C>G	c.(1165-1167)GGC>GGG	p.G389G	ZC3HC1_uc003vph.2_Silent_p.G233G|ZC3HC1_uc010lma.2_Intron	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	389					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					GTACCTCCAGGCCAGGGGTGT	0.617													0	0	0	0.00278	0	24	101										C	129663417	G	C	129663417	2	2	80	1	0	0	0	0	0	0	0	1	17574	1190	42	4		4	ZC3HC1	7	129663417	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	600718	129663417	29475246	93	23981										
CSGALNACT1	55790	broad.mit.edu	37	chr8	19263328	19263328	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttgtcttctgtttctgtttgCgaaggtgagcctctatctcg	10	9	5	1	rs61910741	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:19263328C>G	uc011kyn.1	-	10	2626	c.1562G>C	c.(1561-1563)CGC>CCC	p.R521P	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.R521P|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.R520P	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	521	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		TTTCTGTTTGCGAAGGTGAGC	0.488													0	0	0	0.000602	0	4	77										G	19263328	C	G	19263328	3	3	80	1	0	0	0	0	1	0	0	0	3938	768	27	4	40	4	CSGALNACT1	8	19263328	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		19263328	127100694	94	23982										
WRN	7486	broad.mit.edu	37	chr8	30998994	30998994	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcaggcacagtttatttggcActggcaaggatcaaacagag	12	8	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:30998994A>C	uc003xio.3	+	25	3804	c.3016A>C	c.(3016-3018)ACT>CCT	p.T1006P	WRN_uc010lvk.2_Missense_Mutation_p.T473P	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1006					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTTATTTGGCACTGGCAAGGA	0.383			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	0.010504	0	19	42										C	30998994	A	C	30998994	3	2	80	1	0	0	0	0	1	0	0	0	17399	159	6	5	3110	5	WRN	8	30998994	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	11735666	30998994	115365028	95	23983										
KIAA1429	25962	broad.mit.edu	37	chr8	95523580	95523580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gattgtgagtttttcattaaCtccttgtgtaaaagtcagta	8	5	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:95523580C>T	uc003ygo.1	-	13	3236	c.3223G>A	c.(3223-3225)GTT>ATT	p.V1075I	KIAA1429_uc003ygp.2_Missense_Mutation_p.V1075I|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1075					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTTTCATTAACTCCTTGTGTA	0.363													0	0	0	0.003163	0	15	25										T	95523580	C	T	95523580	3	4	80	1	0	0	0	0	1	0	0	0	8231	565	20	2	2317	2	KIAA1429	8	95523580	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	64524586	95523580	50840442	96	23984										
PTDSS1	9791	broad.mit.edu	37	chr8	97342490	97342490	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	catgatttggtatgcagaacActatggtcaccgagaaaagg	11	7	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:97342490A>G	uc003yht.1	+	11	1325	c.1223A>G	c.(1222-1224)CAC>CGC	p.H408R	PTDSS1_uc003yhu.1_Missense_Mutation_p.H262R	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	408					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TATGCAGAACACTATGGTCAC	0.463													0	0	0	0.00499	0	17	37										G	97342490	A	G	97342490	3	3	80	1	0	0	0	0	1	0	0	0	12736	159	6	5	1265	5	PTDSS1	8	97342490	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	1818910	97342490	49021532	97	23985										
KHDRBS3	10656	broad.mit.edu	37	chr8	136619260	136619260	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tatgattcctatgataacagCtatagcaccccagcccaaag	6	12	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:136619260C>A	uc003yuv.2	+	7	1264	c.870C>A	c.(868-870)AGC>AGA	p.S290R	KHDRBS3_uc003yuw.2_Intron|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	290	Tyr-rich.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			ATGATAACAGCTATAGCACCC	0.403													1	0	2.28855e-06	0.004289	2.40121e-06	32	89										A	136619260	C	A	136619260	3	1	80	1	0	0	0	0	1	0	0	0	8148	796	28	4	896	4	KHDRBS3	8	136619260	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	39276770	136619260	9744762	98	23986										
GPR172A	79581	broad.mit.edu	37	chr8	145583976	145583976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctatcagcttctatcagcccGcagtgcctgcctgctgggcc	10	16	3	0	rs144912258	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:145583976G>A	uc003zcc.1	+	3	981	c.824G>A	c.(823-825)CGC>CAC	p.R275H	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.R275H|GPR172A_uc003zce.1_Missense_Mutation_p.R275H|GPR172A_uc010mfy.1_Missense_Mutation_p.R275H|GPR172A_uc003zcf.1_Missense_Mutation_p.R275H|GPR172A_uc011llc.1_Missense_Mutation_p.R187H	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	275						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CTATCAGCCCGCAGTGCCTGC	0.632													0	0	0	0.010818	0	29	60										A	145583976	G	A	145583976	3	1	80	1	0	0	0	0	1	0	0	0	6669	1087	38	2	830	2	GPR172A	8	145583976	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	8964716	145583976	780046	99	23987										
NFIB	4781	broad.mit.edu	37	chr9	14146709	14146709	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttgatctctttcgtgccatgTtcgacttccagcagctggtg	10	11	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:14146709T>C	uc003zle.2	-	6	1339	c.904A>G	c.(904-906)ACA>GCA	p.T302A	NFIB_uc003zld.2_Missense_Mutation_p.T50A|NFIB_uc003zlf.2_Missense_Mutation_p.T302A|NFIB_uc011lmo.1_Missense_Mutation_p.T302A	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	302					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		TCGTGCCATGTTCGACTTCCA	0.418			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								0	0	0	0.003271	0	32	76										C	14146709	T	C	14146709	3	2	80	1	0	0	0	0	1	0	0	0	10371	1725	60	5	374	5	NFIB	9	14146709	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08		14146709	127066722	100	23988										
FREM1	158326	broad.mit.edu	37	chr9	14819292	14819292	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cccctgaatttagaggaaatCcattcagctccacccttccg	6	15	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:14819292C>G	uc003zlm.2	-	14	3076	c.2486G>C	c.(2485-2487)GGA>GCA	p.G829A	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	829	CSPG 5.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TAGAGGAAATCCATTCAGCTC	0.428													0	0	0	0.006214	0	9	29										G	14819292	C	G	14819292	3	3	80	1	0	0	0	0	1	0	0	0	6044	855	30	1	4199	1	FREM1	9	14819292	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	672583	14819292	126394139	101	23989										
NOL6	65083	broad.mit.edu	37	chr9	33467712	33467712	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgggactgggggtcgagagtGagccagcaggttcagccgag	19	8	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:33467712G>A	uc003zsz.2	-	12	1680	c.1579C>T	c.(1579-1581)CAC>TAC	p.H527Y	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Missense_Mutation_p.H527Y|NOL6_uc010mjv.2_Missense_Mutation_p.H524Y|NOL6_uc011lob.1_Missense_Mutation_p.H475Y|NOL6_uc003ztb.1_Missense_Mutation_p.H527Y	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	527					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTCGAGAGTGAGCCAGCAGG	0.622													0	0	0	0.010729	0	12	41										A	33467712	G	A	33467712	3	1	80	1	0	0	0	0	1	0	0	0	10525	1290	45	1	1921	1	NOL6	9	33467712	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	18648420	33467712	107745719	102	23990										
C9orf25	203259	broad.mit.edu	37	chr9	34401056	34401056	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgaggtctaggtcctcgtcgTcggggatctcatctaaccgg	13	11	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:34401056T>C	uc011lok.1	-	6	771	c.464A>G	c.(463-465)GAC>GGC	p.D155G	C9orf25_uc003zuj.2_Missense_Mutation_p.D138G|C9orf25_uc003zuk.2_Missense_Mutation_p.D127G|C9orf25_uc011lol.1_Missense_Mutation_p.D143G|C9orf25_uc003zul.2_Missense_Mutation_p.D126G	NM_147202	NP_671735	Q8IW50	CI025_HUMAN	hypothetical protein LOC203259	155											0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.0858)		GTCCTCGTCGTCGGGGATCTC	0.617													0	0	0	0.001855	0	13	73										C	34401056	T	C	34401056	3	2	80	1	0	0	0	0	1	0	0	0	2476	1667	58	5	97	5	C9orf25	9	34401056	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	933344	34401056	106812375	103	23991										
KIAA1045	23349	broad.mit.edu	37	chr9	34971556	34971556	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cggctccgagatgggcgcggCgtggagcctgaggagtttga	19	9	0	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:34971556C>T	uc003zvq.2	+	2	439	c.261C>T	c.(259-261)GGC>GGT	p.G87G	KIAA1045_uc003zvr.2_Silent_p.G87G	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	87							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			ATGGGCGCGGCGTGGAGCCTG	0.617													0	0	0	0.01441	0	54	107										T	34971556	C	T	34971556	2	4	80	1	0	0	0	0	0	0	0	1	8207	755	27	2		2	KIAA1045	9	34971556	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	570500	34971556	106241875	104	23992										
POLR1E	64425	broad.mit.edu	37	chr9	37486692	37486692	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atctcattcttgggctgcacTcttacagtccagttctccaa	6	13	4	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:37486692T>G	uc003zzz.1	+	1	543	c.255T>G	c.(253-255)ACT>ACG	p.T85T	POLR1E_uc011lqj.1_Intron|POLR1E_uc003zzy.1_Intron|POLR1E_uc011lqk.1_Intron	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	85					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		TGGGCTGCACTCTTACAGTCC	0.453													0	0	0	0.003755	0	31	91										G	37486692	T	G	37486692	2	3	80	1	0	0	0	0	0	0	0	1	12213	1566	54	5		5	POLR1E	9	37486692	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	2515136	37486692	103726739	105	23993										
ANKRD20A4	728747	broad.mit.edu	37	chr9	69423627	69423627	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gagagaacacaagatgtttcTgtacaagtagaaatgagttc	10	5	1	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:69423627T>C	uc004afn.2	+	15	2035	c.1923T>C	c.(1921-1923)TCT>TCC	p.S641S	uc010mnx.1_5'Flank	NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	641	Potential.										0						AAGATGTTTCTGTACAAGTAG	0.338													0	0	0	0.011902	0	34	305										C	69423627	T	C	69423627	2	2	80	1	0	0	0	0	0	0	0	1	650	1567	55	5		5	ANKRD20A4	9	69423627	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	31936935	69423627	71789804	106	23994										
ZFAND5	7763	broad.mit.edu	37	chr9	74970975	74970975	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agttgtgcttgtcagagtaaCggtgaagtccacaaaacaaa	10	7	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:74970975C>G	uc004aiv.2	-	6	814	c.536G>C	c.(535-537)CGT>CCT	p.R179P	ZFAND5_uc010mox.1_Missense_Mutation_p.R76P|ZFAND5_uc010moy.1_Missense_Mutation_p.R179P|ZFAND5_uc004aix.2_Missense_Mutation_p.R179P|ZFAND5_uc004aiw.2_Missense_Mutation_p.R179P|ZFAND5_uc004aiy.2_Missense_Mutation_p.R179P	NM_006007	NP_005998	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	179	AN1-type.						DNA binding|zinc ion binding				0						GTCAGAGTAACGGTGAAGTCC	0.383													0	0	0	0.00333	0	23	51										G	74970975	C	G	74970975	3	3	80	1	0	0	0	0	1	0	0	0	17627	536	19	4	109	4	ZFAND5	9	74970975	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	5547348	74970975	66242456	107	23995										
PCSK5	5125	broad.mit.edu	37	chr9	78506171	78506171	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctggcgctgctcgggggctGcctgctccccgtgtgtcgga	17	14	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:78506171G>T	uc004ajz.2	+	1	612	c.74G>T	c.(73-75)TGC>TTC	p.C25F	PCSK5_uc004ajy.2_Missense_Mutation_p.C25F|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	25					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CTCGGGGGCTGCCTGCTCCCC	0.701													1	0	2.98393e-07	0.00278	3.15022e-07	24	57										T	78506171	G	T	78506171	3	4	80	1	0	0	0	0	1	0	0	0	11603	1319	46	4	76	4	PCSK5	9	78506171	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3535196	78506171	62707260	108	23996										
GKAP1	80318	broad.mit.edu	37	chr9	86403527	86403527	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgtaaatacctttttgtgctCttcatattctagtttactta	4	7	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:86403527C>G	uc004amy.2	-	5	923	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	GKAP1_uc004amz.2_Missense_Mutation_p.E143Q|GKAP1_uc011lsu.1_RNA	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	143	Potential.				signal transduction	Golgi apparatus					0						TTTTTGTGCTCTTCATATTCT	0.284													0	0	0	0.009535	0	30	73										G	86403527	C	G	86403527	3	3	80	1	0	0	0	0	1	0	0	0	6423	922	32	1	709	1	GKAP1	9	86403527	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	7897356	86403527	54809904	109	23997										
NTRK2	4915	broad.mit.edu	37	chr9	87338533	87338533	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acctaacctcactgtggaggAaggaaagtctatcacattat	8	9	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:87338533A>T	uc004aoa.1	+	9	1567	c.629A>T	c.(628-630)GAA>GTA	p.E210V	NTRK2_uc004anv.1_Missense_Mutation_p.E210V|NTRK2_uc004any.1_Missense_Mutation_p.E210V|NTRK2_uc004anz.1_Missense_Mutation_p.E210V|NTRK2_uc011lsz.1_Missense_Mutation_p.E210V|NTRK2_uc011lta.1_Missense_Mutation_p.E210V|NTRK2_uc004aob.1_Missense_Mutation_p.E210V|NTRK2_uc011ltb.1_Missense_Mutation_p.E54V	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	210	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						ACTGTGGAGGAAGGAAAGTCT	0.423										TSP Lung(25;0.17)			0	0	0	0.00333	0	26	92										T	87338533	A	T	87338533	3	4	80	1	0	0	0	0	1	0	0	0	10707	246	9	5	651	5	NTRK2	9	87338533	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	935006	87338533	53874898	110	23998										
TTLL11	158135	broad.mit.edu	37	chr9	124751938	124751938	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctggagggtccctgccaggcGgatgtcactggggtctttaa	15	10	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:124751938G>A	uc004blt.1	-	4	1263	c.1075C>T	c.(1075-1077)CGC>TGC	p.R359C	TTLL11_uc011lyl.1_Missense_Mutation_p.R359C|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.R36C|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	359	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CCTGCCAGGCGGATGTCACTG	0.517													0	0	0	0.01441	0	50	110										A	124751938	G	A	124751938	3	1	80	1	0	0	0	0	1	0	0	0	16721	1116	39	2	1429	2	TTLL11	9	124751938	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	37413405	124751938	16461493	111	23999										
OR1J2	26740	broad.mit.edu	37	chr9	125273238	125273238	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctgctcatccagctggactCtcaccttcacacccccatgt	6	18	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:125273238C>G	uc004bmj.1	+	4	1013	c.158C>G	c.(157-159)TCT>TGT	p.S53C	OR1J2_uc011lyv.1_Missense_Mutation_p.S53C	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						CAGCTGGACTCTCACCTTCAC	0.557													0	0	0	0.01441	0	64	141										G	125273238	C	G	125273238	3	3	80	1	0	0	0	0	1	0	0	0	10960	913	32	1	160	1	OR1J2	9	125273238	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	521300	125273238	15940193	112	24000										
RALGPS1	9649	broad.mit.edu	37	chr9	129957439	129957439	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcctgacacatctgttgctgGcagcctccccacacctccag	7	18	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:129957439G>A	uc004bqo.1	+	12	1247	c.980G>A	c.(979-981)GGC>GAC	p.G327D	RALGPS1_uc011mac.1_Missense_Mutation_p.G327D|RALGPS1_uc004bqq.3_Missense_Mutation_p.G327D	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	327					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						TCTGTTGCTGGCAGCCTCCCC	0.632													0	0	0	0.005443	0	27	83										A	129957439	G	A	129957439	3	1	80	1	0	0	0	0	1	0	0	0	13017	1203	42	2	1022	2	RALGPS1	9	129957439	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	4684201	129957439	11255992	113	24001										
TTF1	7270	broad.mit.edu	37	chr9	135275538	135275538	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaagctgtttcacggcagaaCccaaatccgcatctgaatca	8	12	3	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:135275538C>G	uc004cbl.2	-	3	1527	c.1475G>C	c.(1474-1476)GGT>GCT	p.G492A	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_5'UTR	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	492					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CACGGCAGAACCCAAATCCGC	0.468													0	0	0	0.008361	0	32	105										G	135275538	C	G	135275538	3	3	80	1	0	0	0	0	1	0	0	0	16715	507	18	4	1278	4	TTF1	9	135275538	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	5318099	135275538	5937893	114	24002										
FCN1	2219	broad.mit.edu	37	chr9	137804955	137804955	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgccagccgctcaggaaataCccccggtctagcaggtcctt	10	15	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:137804955C>T	uc004cfi.2	-	6	467	c.375G>A	c.(373-375)GGG>GGA	p.G125G		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	125	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TCAGGAAATACCCCCGGTCTA	0.677													0	0	0	0.006214	0	10	12										T	137804955	C	T	137804955	2	4	80	1	0	0	0	0	0	0	0	1	5791	494	18	2		2	FCN1	9	137804955	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	2529417	137804955	3408476	115	24003										
BICC1	80114	broad.mit.edu	37	chr10	60560788	60560788	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agtggaactattgcaaggcaCgaaaaactcacacttacagt	8	9	1	0	rs139193189	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:60560788C>T	uc001jki.1	+	14	1997	c.1997C>T	c.(1996-1998)ACG>ATG	p.T666M	BICC1_uc001jkj.1_Missense_Mutation_p.T307M	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	666					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TTGCAAGGCACGAAAAACTCA	0.383													0	0	0	0.013537	0	13	54										T	60560788	C	T	60560788	3	4	80	1	0	0	0	0	1	0	0	0	1427	536	19	2	2051	2	BICC1	10	60560788	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		60560788	74973959	116	24004										
MAT1A	4143	broad.mit.edu	37	chr10	82036336	82036336	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	actgcgccattgtcctgcatGtactgaactgtcacctgtcc	8	14	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:82036336G>T	uc001kbw.2	-	6	819	c.564C>A	c.(562-564)TAC>TAA	p.Y188*		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	188					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGTCCTGCATGTACTGAACTG	0.592													1	0	7.05121e-23	0.010771	7.98825e-23	45	105										T	82036336	G	T	82036336	4	4	80	1	0	0	0	0	0	1	0	0	9329	1372	48	4	639	4	MAT1A	10	82036336	Nonsense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	21475548	82036336	53498411	117	24005										
TNKS2	80351	broad.mit.edu	37	chr10	93582057	93582057	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccccttctcattgtagtgatCtggtaccattacacaatgcc	6	13	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:93582057C>G	uc001khp.2	+	7	1030	c.733C>G	c.(733-735)CTG>GTG	p.L245V		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	245	ANK 5.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				TTGTAGTGATCTGGTACCATT	0.328													0	0	0	0.006999	0	38	116										G	93582057	C	G	93582057	3	3	80	1	0	0	0	0	1	0	0	0	16318	912	32	1	759	1	TNKS2	10	93582057	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	11545721	93582057	41952690	118	24006										
SFRP5	6425	broad.mit.edu	37	chr10	99529459	99529459	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cacatctgctccatgaggccGtcagcactgtgctccatctc	8	16	3	1	rs144832598	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:99529459G>A	uc001kor.3	-	2	739	c.573C>T	c.(571-573)GAC>GAT	p.D191D		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	191	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		CCATGAGGCCGTCAGCACTGT	0.602													0	0	0	0.009096	0	3	21										A	99529459	G	A	99529459	2	1	80	1	0	0	0	0	0	0	0	1	14164	1136	40	2		2	SFRP5	10	99529459	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	5947402	99529459	36005288	119	24007										
SEC31B	25956	broad.mit.edu	37	chr10	102262099	102262099	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcagtagatttcctgatcccAaggcctcctgcagctcagct	8	14	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:102262099A>G	uc001krc.1	-	11	1424	c.1322T>C	c.(1321-1323)TTG>TCG	p.L441S	SEC31B_uc010qpo.1_Missense_Mutation_p.L440S|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_Missense_Mutation_p.L10S	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	441					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TCCTGATCCCAAGGCCTCCTG	0.517													0	0	0	0.008361	0	32	72										G	102262099	A	G	102262099	3	3	80	1	0	0	0	0	1	0	0	0	13999	131	5	5	2281	5	SEC31B	10	102262099	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	2732640	102262099	33272648	120	24008										
FAM178A	55719	broad.mit.edu	37	chr10	102676648	102676648	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtcactaaagaaaaaacatcGatccccagagagaaggaagt	9	8	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:102676648G>C	uc001krt.3	+	3	1048	c.506G>C	c.(505-507)CGA>CCA	p.R169P	FAM178A_uc001krr.1_Missense_Mutation_p.R169P|FAM178A_uc001krs.2_Missense_Mutation_p.R169P|FAM178A_uc001kru.1_Missense_Mutation_p.R105P	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	169											0						AAAAAACATCGATCCCCAGAG	0.383													0	0	0	0.005443	0	29	59										C	102676648	G	C	102676648	3	2	80	1	0	0	0	0	1	0	0	0	5503	1058	37	1	516	1	FAM178A	10	102676648	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	414549	102676648	32858099	121	24009										
SLK	9748	broad.mit.edu	37	chr10	105779625	105779625	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aatggccatgtttaagaagaGtttgagaattaactcaacag	9	5	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:105779625G>T	uc001kxo.1	+	16	3300	c.3266G>T	c.(3265-3267)AGT>ATT	p.S1089I	SLK_uc001kxp.1_Missense_Mutation_p.S1058I	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1089					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TTTAAGAAGAGTTTGAGAATT	0.378													1	0	8.72198e-27	0.01441	1.00141e-26	43	95										T	105779625	G	T	105779625	3	4	80	1	0	0	0	0	1	0	0	0	14748	1029	36	4	3328	4	SLK	10	105779625	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3102977	105779625	29755122	122	24010										
PDZD8	118987	broad.mit.edu	37	chr10	119043391	119043391	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcagaaaggcgagttttagaGacttgacgcaaatttaataa	9	5	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:119043391G>C	uc001lde.1	-	5	3052	c.2853C>G	c.(2851-2853)GTC>GTG	p.V951V		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	951					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		GAGTTTTAGAGACTTGACGCA	0.433													0	0	0	0.01441	0	81	218										C	119043391	G	C	119043391	2	2	80	1	0	0	0	0	0	0	0	1	11705	929	33	1		1	PDZD8	10	119043391	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	13263766	119043391	16491356	123	24011										
EBF3	253738	broad.mit.edu	37	chr10	131761227	131761227	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gttgctgtacaataactggaGtttatagtggatgccgttgt	12	5	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:131761227G>C	uc001lki.1	-	3	393	c.334C>G	c.(334-336)CTC>GTC	p.L112V	EBF3_uc010qur.1_3'UTR	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	112					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AATAACTGGAGTTTATAGTGG	0.507													0	0	0	0.014323	0	21	67										C	131761227	G	C	131761227	3	2	80	1	0	0	0	0	1	0	0	0	4882	1029	36	4	1377	4	EBF3	10	131761227	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	12717836	131761227	3773520	124	24012										
CTSD	1509	broad.mit.edu	37	chr11	1782613	1782613	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cgcctgggagtactttgagaCggggcctttggcaatcaggt	15	9	1	1	rs143517230	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:1782613C>T	uc001luc.1	-	2	287	c.154G>A	c.(154-156)GTC>ATC	p.V52I	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	52					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACTTTGAGACGGGGCCTTTG	0.612													0	0	0	0.007413	0	19	23										T	1782613	C	T	1782613	3	4	80	1	0	0	0	0	1	0	0	0	4032	536	19	2	1116	2	CTSD	11	1782613	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		1782613	133223903	125	24013										
NUP98	4928	broad.mit.edu	37	chr11	3794940	3794940	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atgttagtgctaactccagcTttgaccatagtatctgtacc	7	10	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:3794940T>G	uc001lyh.2	-	6	816	c.525A>C	c.(523-525)AAA>AAC	p.K175N	NUP98_uc001lyi.2_Missense_Mutation_p.K175N|NUP98_uc001lyj.1_Missense_Mutation_p.K175N|NUP98_uc001lyk.1_Missense_Mutation_p.K175N|NUP98_uc010qxv.1_Missense_Mutation_p.K138N	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	175	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TAACTCCAGCTTTGACCATAG	0.368			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.00245	0	11	23										G	3794940	T	G	3794940	3	3	80	1	0	0	0	0	1	0	0	0	10773	1606	56	5	5061	5	NUP98	11	3794940	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	2012327	3794940	131211576	126	24014										
OR10A5	144124	broad.mit.edu	37	chr11	6866955	6866955	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaaataagtgaatttatcctCatgagcttctcttccctacc	5	11	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:6866955C>T	uc001met.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AATTTATCCTCATGAGCTTCT	0.413													0	0	0	0.01441	0	95	125										T	6866955	C	T	6866955	2	4	80	1	0	0	0	0	0	0	0	1	10893	813	29	1		1	OR10A5	11	6866955	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	3072015	6866955	128139561	127	24015										
OR10V1	390201	broad.mit.edu	37	chr11	59480630	59480630	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctggcgcccttctgctgacCggatccgtaaaatggctacc	11	14	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:59480630C>T	uc001nof.1	-	1	689	c.689G>A	c.(688-690)CGG>CAG	p.R230Q		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTGCTGACCGGATCCGTAA	0.502													0	0	0	0.004289	0	36	66										T	59480630	C	T	59480630	3	4	80	1	0	0	0	0	1	0	0	0	10920	652	23	2	244	2	OR10V1	11	59480630	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	52613675	59480630	75525886	128	24016										
MARK2	2011	broad.mit.edu	37	chr11	63663087	63663089	+	In_Frame_Del	DEL	CTC	CTC	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	attgacaagactcaactgaaCtcctccagcctccagaaagt							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:63663087_63663089delCTC	uc001nxw.2	+	3	849_851	c.270_272delCTC	c.(268-273)AACTCC>AAC	p.S93del	MARK2_uc001nxx.2_In_Frame_Del_p.S93del|MARK2_uc001nxy.2_In_Frame_Del_p.S93del|MARK2_uc001nxv.3_In_Frame_Del_p.S93del|MARK2_uc001nxz.3_In_Frame_Del_p.S60del|MARK2_uc009yoy.2_In_Frame_Del_p.S60del	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	93	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.N57K(1)		stomach(1)|ovary(1)|lung(1)	3						CTCAACTGAACTCCTCCAGCCTC	0.35																		29	173	---	---								-	63663089	CTC	-	63663087	7	5	80	1	0	1	0	1	0	0	0	0	9313	564	20	0	280	0	MARK2	11	63663087	In_Frame_Del	DEL	CTC	TCGA-FD-A3SL-01A-21D-A22Z-08	4182457	63663087	71343429	129	24017										
GAB2	9846	broad.mit.edu	37	chr11	77991880	77991880	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tggagtgatcgttcttgtagTattccagaacatctgggtca	11	7	3	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:77991880T>C	uc001ozh.2	-	2	143	c.143A>G	c.(142-144)TAC>TGC	p.Y48C	GAB2_uc001ozg.2_Missense_Mutation_p.Y10C	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	48	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			GTTCTTGTAGTATTCCAGAAC	0.507													0	0	0	0.004878	0	38	71										C	77991880	T	C	77991880	3	2	80	1	0	0	0	0	1	0	0	0	6149	1638	57	5	1923	5	GAB2	11	77991880	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	14328793	77991880	57014636	130	24018										
GRM5	2915	broad.mit.edu	37	chr11	88301116	88301116	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	caccacagctgcaatgggttCagggtcaccccatcgaagat	10	13	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:88301116C>T	uc001pcq.2	-	7	1935	c.1735G>A	c.(1735-1737)GAA>AAA	p.E579K	GRM5_uc009yvm.2_Missense_Mutation_p.E579K	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	579	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GCAATGGGTTCAGGGTCACCC	0.488													0	0	0	0.004007	0	16	25										T	88301116	C	T	88301116	3	4	80	1	0	0	0	0	1	0	0	0	6800	835	29	1	1915	1	GRM5	11	88301116	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	10309236	88301116	46705400	131	24019										
ATM	472	broad.mit.edu	37	chr11	108122624	108122624	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atagttccaggaacggtaaaAatgggaatagagcaaaatat	10	4	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:108122624A>G	uc001pkb.1	+	11	2053	c.1668A>G	c.(1666-1668)AAA>AAG	p.K556K	ATM_uc009yxr.1_Silent_p.K556K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	556					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAACGGTAAAAATGGGAATAG	0.358			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.01441	0	49	65										G	108122624	A	G	108122624	2	3	80	1	0	0	0	0	0	0	0	1	1109	11	1	5		5	ATM	11	108122624	Silent	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	19821508	108122624	26883892	132	24020										
GRIK4	2900	broad.mit.edu	37	chr11	120531041	120531041	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atagaagatgccccgcgtctCggcgcctttggtgctgcttc	12	13	1	2	rs138617238		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:120531041C>T	uc001pxn.2	+	3	301	c.14C>T	c.(13-15)TCG>TTG	p.S5L	GRIK4_uc009zav.1_Missense_Mutation_p.S5L|GRIK4_uc009zaw.1_Missense_Mutation_p.S5L|GRIK4_uc009zax.1_Missense_Mutation_p.S5L	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	5					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CCCCGCGTCTCGGCGCCTTTG	0.647											OREG0021424	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	60										T	120531041	C	T	120531041	3	4	80	1	0	0	0	0	1	0	0	0	6776	893	31	1	16	1	GRIK4	11	120531041	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	12408417	120531041	14475475	133	24021										
HSPA8	3312	broad.mit.edu	37	chr11	122928487	122928487	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cctgaggaagcaccaccagaGggaggagctccaccaccagg	13	14	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:122928487G>A	uc001pyo.2	-	9	1974	c.1896C>T	c.(1894-1896)CCC>CCT	p.P632P	HSPA8_uc009zbc.2_Silent_p.P396P|HSPA8_uc001pyp.2_Silent_p.P479P|HSPA8_uc010rzu.1_Silent_p.P555P	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	632					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CACCACCAGAGGGAGGAGCTC	0.512													0	0	0	0.00245	0	14	78										A	122928487	G	A	122928487	2	1	80	1	0	0	0	0	0	0	0	1	7416	987	35	2		2	HSPA8	11	122928487	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	2397446	122928487	12078029	134	24022										
C11orf45	219833	broad.mit.edu	37	chr11	128773387	128773387	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaggaggtgttaccctcactCctgacagaggcagacctgcc	12	13	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:128773387C>A	uc001qeu.2	-	3	350	c.156G>T	c.(154-156)AGG>AGT	p.R52S	KCNJ5_uc001qet.2_Intron|KCNJ5_uc009zck.2_Intron|C11orf45_uc009zcl.2_Missense_Mutation_p.R52S|C11orf45_uc001qev.2_Missense_Mutation_p.R52S	NM_145013	NP_659450	Q8TAV5	CK045_HUMAN	hypothetical protein LOC219833 precursor	52						extracellular region					0	all_hematologic(175;0.0641)	Lung NSC(97;0.00521)|Breast(109;0.00715)|all_lung(97;0.0111)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.00531)|LUSC - Lung squamous cell carcinoma(976;0.0193)|Lung(977;0.0195)		TACCCTCACTCCTGACAGAGG	0.507													1	0	0.00198382	0.001984	0.00201935	6	42										A	128773387	C	A	128773387	3	1	80	1	0	0	0	0	1	0	0	0	1642	854	30	3	289	3	C11orf45	11	128773387	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	5844900	128773387	6233129	135	24023										
DPPA3	359787	broad.mit.edu	37	chr12	7868804	7868804	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcccatgaagcatgaaagaaGaccaacaaacaaggagccta	8	10	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:7868804G>A	uc001qtf.2	+	3	416	c.338G>A	c.(337-339)AGA>AAA	p.R113K		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	113						cytoplasm|nucleus					0				Kidney(36;0.0887)		CATGAAAGAAGACCAACAAAC	0.284													0	0	0	0.001984	0	6	20										A	7868804	G	A	7868804	3	1	80	1	0	0	0	0	1	0	0	0	4735	942	33	1	348	1	DPPA3	12	7868804	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		7868804	125983091	136	24024										
CREBL2	1389	broad.mit.edu	37	chr12	12788795	12788795	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aagcaaaacttgagaggagcCggcagagtgcaagagaatgc	14	7	0	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:12788795C>T	uc001rap.1	+	2	376	c.100C>T	c.(100-102)CGG>TGG	p.R34W	CREBL2_uc009zhv.1_5'Flank	NM_001310	NP_001301	O60519	CRBL2_HUMAN	cAMP responsive element binding protein-like 2	34	Basic motif.				cell cycle|signal transduction	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Prostate(47;0.0684)		BRCA - Breast invasive adenocarcinoma(232;0.0503)		TGAGAGGAGCCGGCAGAGTGC	0.488													0	0	0	0.010729	0	11	14										T	12788795	C	T	12788795	3	4	80	1	0	0	0	0	1	0	0	0	3862	643	23	2	106	2	CREBL2	12	12788795	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4919991	12788795	121063100	137	24025										
C12orf35	55196	broad.mit.edu	37	chr12	32138036	32138037	+	Frame_Shift_Ins	INS	-	-	TA													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gttagaccaagggaacgtatINStagatatggaagtaaagaaa							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:32138036_32138037insTA	uc001rks.2	+	4	4561_4562	c.4147_4148insTA	c.(4147-4149)TTAfs	p.L1383fs	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1383										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			AGGGAACGTATTAGATATGGAA	0.347																		11	66	---	---								TA	32138037	-	TA	32138036	7	5	80	1	0	1	1	0	0	0	0	0	1682	1490	52	0	4149	0	C12orf35	12	32138036	Frame_Shift_Ins	INS	-	TCGA-FD-A3SL-01A-21D-A22Z-08	19349241	32138036	101713859	138	24026										
ARF3	377	broad.mit.edu	37	chr12	49334730	49334730	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acatccaagctgtgctcttaCcaatggtagggatggtggtg	13	8	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:49334730C>G	uc001rsr.2	-	2	401	c.148_splice	c.e2+1	p.G50_splice	ARF3_uc010smc.1_Splice_Site_p.G50_splice	NM_001659	NP_001650	P61204	ARF3_HUMAN	ADP-ribosylation factor 3						protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity				0						TGTGCTCTTACCAATGGTAGG	0.587													0	0	0	0.01441	0	56	66										G	49334730	C	G	49334730	5	3	80	1	0	0	0	0	0	0	1	0	845	521	18	4	412	4	ARF3	12	49334730	Splice_Site	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	17196694	49334730	84517165	139	24027										
MLL2	8085	broad.mit.edu	37	chr12	49424468	49424475	+	Frame_Shift_Del	DEL	GACTGGGC	GACTGGGC	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctcagctggctctgcccattGactgggcagccactgccaaa							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			GACTGGGC	-	GACTGGGC	GACTGGGC		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:49424468_49424475delGACTGGGC	uc001rta.3	-	41	13748_13755	c.13748_13755delGCCCAGTC	c.(13747-13755)TGCCCAGTCfs	p.C4583fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4583_4585					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCTGCCCATTGACTGGGCAGCCACTGCC	0.577			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								10	29	---	---								-	49424475	GACTGGGC	-	49424468	7	5	80	1	0	1	0	1	0	0	0	0	9621	1277	45	0	2914	0	MLL2	12	49424468	Frame_Shift_Del	DEL	GACTGGGC	TCGA-FD-A3SL-01A-21D-A22Z-08	89738	49424468	84427427	140	24028										
LETMD1	25875	broad.mit.edu	37	chr12	51442969	51442969	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtacacaatcttcatgaaagGtaaaaacgaaactacaatag	6	7	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:51442969G>A	uc001rxm.2	+	2	330	c.274_splice	c.e2+1	p.G92_splice	LETMD1_uc010smz.1_Splice_Site_p.G92_splice|LETMD1_uc010sna.1_Splice_Site_p.E92_splice|LETMD1_uc001rxl.2_Splice_Site_p.G36_splice|LETMD1_uc009zlv.2_Splice_Site|LETMD1_uc001rxs.2_Splice_Site_p.E92_splice|LETMD1_uc009zlw.2_Splice_Site_p.G92_splice|LETMD1_uc001rxn.2_Splice_Site|LETMD1_uc001rxo.2_Splice_Site|LETMD1_uc001rxp.2_Intron|LETMD1_uc001rxq.2_Splice_Site_p.G92_splice|LETMD1_uc001rxr.2_Splice_Site|LETMD1_uc001rxt.2_Splice_Site	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1							integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						TTCATGAAAGGTAAAAACGAA	0.413													0	0	0	0.001168	0	5	34										A	51442969	G	A	51442969	5	1	80	1	0	0	0	0	0	0	1	0	8736	1275	44	2	281	2	LETMD1	12	51442969	Splice_Site	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	2018501	51442969	82408926	141	24029										
KRT7	3855	broad.mit.edu	37	chr12	52642496	52642496	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtcctgggctcctgaaggcTtattccatccggaccgcatc	11	14	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:52642496T>G	uc001saa.1	+	9	1489	c.1362T>G	c.(1360-1362)GCT>GCG	p.A454A	KRT86_uc010snq.1_5'Flank	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	454	Tail.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCCTGAAGGCTTATTCCATCC	0.642													0	0	0	0.006122	0	17	31										G	52642496	T	G	52642496	2	3	80	1	0	0	0	0	0	0	0	1	8483	1596	56	5		5	KRT7	12	52642496	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	1199527	52642496	81209399	142	24030										
STAT6	6778	broad.mit.edu	37	chr12	57501482	57501482	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagtgtctgaaagtagggcaCtagccaagttgcagcagaag	13	8	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:57501482C>T	uc009zpe.2	-	3	412	c.161G>A	c.(160-162)AGT>AAT	p.S54N	STAT6_uc009zpf.2_Missense_Mutation_p.S54N|STAT6_uc001sna.2_Missense_Mutation_p.S54N|STAT6_uc010srb.1_Translation_Start_Site|STAT6_uc010src.1_Intron|STAT6_uc010srd.1_Intron|STAT6_uc009zpg.2_Missense_Mutation_p.S103N	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	54					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						AAGTAGGGCACTAGCCAAGTT	0.607													0	0	0	0.001984	0	5	44										T	57501482	C	T	57501482	3	4	80	1	0	0	0	0	1	0	0	0	15269	565	20	2	2462	2	STAT6	12	57501482	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4858986	57501482	76350413	143	24031										
LRP1	4035	broad.mit.edu	37	chr12	57556105	57556105	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cctctccatccctagattgtGtatgaaggtcctgagctgaa	9	11	1	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:57556105G>T	uc001snd.2	+	14	2674	c.2208G>T	c.(2206-2208)GTG>GTT	p.V736V		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	736	LDL-receptor class B 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTAGATTGTGTATGAAGGTC	0.488													1	0	1.45844e-13	0.013726	1.60428e-13	33	85										T	57556105	G	T	57556105	2	4	80	1	0	0	0	0	0	0	0	1	8951	1364	48	4		4	LRP1	12	57556105	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	54623	57556105	76295790	144	24032										
NUP107	57122	broad.mit.edu	37	chr12	69113358	69113358	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tttcttttgctattttatagGaacagaattagaacctgttg	7	5	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:69113358G>C	uc001suf.2	+	14	1290	c.1175G>C	c.(1174-1176)GGA>GCA	p.G392A	NUP107_uc001sug.2_Missense_Mutation_p.G239A|NUP107_uc010stj.1_Missense_Mutation_p.G363A	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	392					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TATTTTATAGGAACAGAATTA	0.308													0	0	0	0.013537	0	12	34										C	69113358	G	C	69113358	3	2	80	1	0	0	0	0	1	0	0	0	10753	1188	41	1	1229	1	NUP107	12	69113358	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	11557253	69113358	64738537	145	24033										
TMTC2	160335	broad.mit.edu	37	chr12	83324287	83324287	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcgcctatagaaatgctttgTactaccgcagcaacatggct	9	11	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:83324287T>C	uc001szt.2	+	4	1993	c.1561T>C	c.(1561-1563)TAC>CAC	p.Y521H	TMTC2_uc001szr.1_Missense_Mutation_p.Y521H|TMTC2_uc001szs.1_Missense_Mutation_p.Y521H|TMTC2_uc010suk.1_Missense_Mutation_p.Y276H	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	521	TPR 2.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						AAATGCTTTGTACTACCGCAG	0.418													0	0	0	0.007413	0	17	28										C	83324287	T	C	83324287	3	2	80	1	0	0	0	0	1	0	0	0	16258	1638	57	5	1575	5	TMTC2	12	83324287	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	14210929	83324287	50527608	146	24034										
LRRIQ1	84125	broad.mit.edu	37	chr12	85450778	85450778	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atcagagtcaacccttctatAttctattgaagaaaggagac	7	8	4	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:85450778A>T	uc001tac.2	+	8	2318	c.2207A>T	c.(2206-2208)TAT>TTT	p.Y736F	LRRIQ1_uc001tab.1_Missense_Mutation_p.Y736F|LRRIQ1_uc001taa.1_Missense_Mutation_p.Y711F	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	736										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ACCCTTCTATATTCTATTGAA	0.333													0	0	0	0.01441	0	72	263										T	85450778	A	T	85450778	3	4	80	1	0	0	0	0	1	0	0	0	9029	449	16	5	2233	5	LRRIQ1	12	85450778	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	2126491	85450778	48401117	147	24035										
GALNT4	8693	broad.mit.edu	37	chr12	89917268	89917268	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acgtgggaacacgggtggatCtccaatttgccaccacactg	11	12	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:89917268C>A	uc001tbd.2	-	1	1268	c.1059G>T	c.(1057-1059)GAG>GAT	p.E353D	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Missense_Mutation_p.E350D|GALNT4_uc010suo.1_Missense_Mutation_p.E45D	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	353	Catalytic subdomain B.|Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						ACGGGTGGATCTCCAATTTGC	0.522													1	0	1.73308e-25	0.012319	1.97653e-25	23	125										A	89917268	C	A	89917268	3	1	80	1	0	0	0	0	1	0	0	0	6215	912	32	3	681	3	GALNT4	12	89917268	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4466490	89917268	43934627	148	24036										
ATP2B1	490	broad.mit.edu	37	chr12	90013790	90013790	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcttactttttcagaattatCtcagatgcacccttgctgaa	5	10	3	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:90013790C>G	uc001tbh.2	-	10	1996	c.1815G>C	c.(1813-1815)GAG>GAC	p.E605D	ATP2B1_uc001tbg.2_Missense_Mutation_p.E605D|ATP2B1_uc001tbf.2_Missense_Mutation_p.E275D	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	605	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TCAGAATTATCTCAGATGCAC	0.343													0	0	0	0.012213	0	32	57										G	90013790	C	G	90013790	3	3	80	1	0	0	0	0	1	0	0	0	1139	912	32	1	2049	1	ATP2B1	12	90013790	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	96522	90013790	43838105	149	24037										
BTBD11	121551	broad.mit.edu	37	chr12	107713306	107713306	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acatgagcagcgccggcggcGaccgcctgggccgcggcaag	17	15	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:107713306G>T	uc001tmk.1	+	1	1110	c.589G>T	c.(589-591)GAC>TAC	p.D197Y	BTBD11_uc009zut.1_Missense_Mutation_p.D197Y|BTBD11_uc001tmj.2_Missense_Mutation_p.D197Y	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	197						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CGCCGGCGGCGACCGCCTGGG	0.721													1	0	0.004672	0.004672	0.00472745	3	4										T	107713306	G	T	107713306	3	4	80	1	0	0	0	0	1	0	0	0	1539	1058	37	3	591	3	BTBD11	12	107713306	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	17699516	107713306	26138589	150	24038										
ATP2A2	488	broad.mit.edu	37	chr12	110783086	110783086	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagtgtaaagaggacaacccGgactttgaaggcgtggattg	14	7	0	2	rs147309970		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:110783086G>C	uc001tqk.3	+	18	3203	c.2640G>C	c.(2638-2640)CCG>CCC	p.P880P	ATP2A2_uc001tql.3_Silent_p.P880P|ATP2A2_uc010sxy.1_Silent_p.P853P|ATP2A2_uc001tqn.3_5'Flank|ATP2A2_uc009zvn.2_5'Flank	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	880	Lumenal (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						AGGACAACCCGGACTTTGAAG	0.448													0	0	0	0.01441	0	62	158										C	110783086	G	C	110783086	2	2	80	1	0	0	0	0	0	0	0	1	1137	1103	39	4		4	ATP2A2	12	110783086	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3069780	110783086	23068809	151	24039										
ATXN2	6311	broad.mit.edu	37	chr12	111953957	111953957	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaacaaattgtggtattgtaCcttctgaagacatgcgttta	9	6	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:111953957C>T	uc001tsj.2	-	10	2017	c.1855_splice	c.e10+1	p.G619_splice	ATXN2_uc001tsh.2_Splice_Site_p.G354_splice|ATXN2_uc001tsi.2_Splice_Site_p.G330_splice|ATXN2_uc001tsk.2_Splice_Site|ATXN2_uc001tsm.1_Splice_Site_p.G354_splice	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2						cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TGGTATTGTACCTTCTGAAGA	0.428													0	0	0	0.001984	0	6	26										T	111953957	C	T	111953957	5	4	80	1	0	0	0	0	0	0	1	0	1211	521	18	2	2149	2	ATXN2	12	111953957	Splice_Site	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1170871	111953957	21897938	152	24040										
HSPB8	26353	broad.mit.edu	37	chr12	119617346	119617346	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cccggggccccactgccaccGccaggtttggggtgcctgcc	14	18	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:119617346G>T	uc001txb.2	+	1	752	c.229G>T	c.(229-231)GCC>TCC	p.A77S	HSPB8_uc001txc.2_Missense_Mutation_p.A77S	NM_014365	NP_055180	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	77					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CACTGCCACCGCCAGGTTTGG	0.672													1	0	0.00010058	0.013537	0.000104886	13	40										T	119617346	G	T	119617346	3	4	80	1	0	0	0	0	1	0	0	0	7423	1087	38	4	231	4	HSPB8	12	119617346	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	7663389	119617346	14234549	153	24041										
VPS37B	79720	broad.mit.edu	37	chr12	123355588	123355588	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctggcaagtgtcatttctttGttaagctgaacattctgtgt	9	7	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:123355588G>A	uc001udl.2	-	2	235	c.132C>T	c.(130-132)AAC>AAT	p.N44N		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	44					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		TCATTTCTTTGTTAAGCTGAA	0.502													0	0	0	0.003163	0	15	45										A	123355588	G	A	123355588	2	1	80	1	0	0	0	0	0	0	0	1	17203	1368	48	2		2	VPS37B	12	123355588	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3738242	123355588	10496307	154	24042										
SBNO1	55206	broad.mit.edu	37	chr12	123815916	123815916	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tccattaggtaggaaagtttCatgttgctgaaaaacaaaag	9	5	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:123815916C>T	uc010tap.1	-	7	916	c.916G>A	c.(916-918)GAA>AAA	p.E306K	SBNO1_uc010tao.1_Missense_Mutation_p.E305K|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.E306K|SBNO1_uc001ueu.2_Missense_Mutation_p.E305K|SBNO1_uc001uev.2_Missense_Mutation_p.E304K|SBNO1_uc009zxy.1_Missense_Mutation_p.E271K	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	306							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		AGGAAAGTTTCATGTTGCTGA	0.363													0	0	0	0.010504	0	21	45										T	123815916	C	T	123815916	3	4	80	1	0	0	0	0	1	0	0	0	13862	835	29	1	3365	1	SBNO1	12	123815916	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	460328	123815916	10035979	155	24043										
MTMR6	9107	broad.mit.edu	37	chr13	25832777	25832777	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgaaatctaatattggaataGttgtcttcattttcataacc	5	6	4	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:25832777G>C	uc001uqf.3	-	7	1099	c.780C>G	c.(778-780)AAC>AAG	p.N260K	MTMR6_uc001uqe.1_Missense_Mutation_p.N260K	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	260	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TATTGGAATAGTTGTCTTCAT	0.294													0	0	0	0.004007	0	16	30										C	25832777	G	C	25832777	3	2	80	1	0	0	0	0	1	0	0	0	9947	1020	36	4	1117	4	MTMR6	13	25832777	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		25832777	89337101	156	24044										
AKAP11	11215	broad.mit.edu	37	chr13	42877222	42877222	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgaaaggaccctggatccatAtagaaatgaggtctcccaac	9	10	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:42877222A>G	uc001uys.1	+	8	4515	c.4340A>G	c.(4339-4341)TAT>TGT	p.Y1447C		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1447				LDPYRNEVSQLYSFSTSLVHSITKDA -> CGPSVELSPWK WQTRCGREGNSWKRE (in Ref. 5; BAA92117).	intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CTGGATCCATATAGAAATGAG	0.388													0	0	0	0.007835	0	39	87										G	42877222	A	G	42877222	3	3	80	1	0	0	0	0	1	0	0	0	447	449	16	5	4362	5	AKAP11	13	42877222	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	17044445	42877222	72292656	157	24045										
RB1	5925	broad.mit.edu	37	chr13	49039151	49039160	+	Frame_Shift_Del	DEL	GATCAAAGAA	GATCAAAGAA	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagacattcaaacgtgttttGatcaaagaagaggagtatga					rs3092905		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			GATCAAAGAA	-	GATCAAAGAA	GATCAAAGAA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:49039151_49039160delGATCAAAGAA	uc001vcb.2	+	22	2395_2404	c.2229_2238delGATCAAAGAA	c.(2227-2238)TTGATCAAAGAAfs	p.L743fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	743_746	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AACGTGTTTTGATCAAAGAAGAGGAGTATG	0.286		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)								7	39	---	---								-	49039160	GATCAAAGAA	-	49039151	7	5	80	1	0	1	0	1	0	0	0	0	13098	1281	45	0	2315	0	RB1	13	49039151	Frame_Shift_Del	DEL	GATCAAAGAA	TCGA-FD-A3SL-01A-21D-A22Z-08	6161929	49039151	66130727	158	24046										
RB1	5925	broad.mit.edu	37	chr13	49039203	49039203	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tattctataactcggtcttcAtgcagagactgaaaacaaat	6	8	3	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:49039203A>C	uc001vcb.2	+	22	2447	c.2281A>C	c.(2281-2283)ATG>CTG	p.M761L		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	761	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)|p.M761fs*4(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCGGTCTTCATGCAGAGACT	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.006214	0	9	50										C	49039203	A	C	49039203	3	2	80	1	0	0	0	0	1	0	0	0	13098	217	8	5	2367	5	RB1	13	49039203	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	52	49039203	66130675	159	24047										
FARP1	10160	broad.mit.edu	37	chr13	99020427	99020427	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tctttccgcctgaccacacaCaactccaagaagaactcaca	4	16	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:99020427C>T	uc001vnj.2	+	5	712	c.376C>T	c.(376-378)CAA>TAA	p.Q126*	FARP1_uc001vnh.2_Nonsense_Mutation_p.Q126*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	126	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGACCACACACAACTCCAAGA	0.373													0	0	0	0.001168	0	6	38										T	99020427	C	T	99020427	4	4	80	1	0	0	0	0	0	1	0	0	5676	479	17	2	613	2	FARP1	13	99020427	Nonsense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	49981224	99020427	16149451	160	24048										
TNFSF13B	10673	broad.mit.edu	37	chr13	108922250	108922250	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gttcaagtagtgatatggatGactccacagaaagggagcag	13	6	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:108922250G>C	uc001vqr.2	+	1	274	c.7G>C	c.(7-9)GAC>CAC	p.D3H	TNFSF13B_uc010agj.2_Missense_Mutation_p.D3H	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	3	Cytoplasmic (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			TGATATGGATGACTCCACAGA	0.443													0	0	0	0.006999	0	39	64										C	108922250	G	C	108922250	3	2	80	1	0	0	0	0	1	0	0	0	16303	1290	45	1	9	1	TNFSF13B	13	108922250	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	9901823	108922250	6247628	161	24049										
RNASE7	84659	broad.mit.edu	37	chr14	21511342	21511342	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cattaacaagcacacaaaacGgtgcaaagacctcaacacct	5	13	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:21511342G>T	uc001vzk.3	+	2	448	c.191G>T	c.(190-192)CGG>CTG	p.R64L	NDRG2_uc010tll.1_Intron|RNASE7_uc001vzl.2_RNA	NM_032572	NP_115961	Q9H1E1	RNAS7_HUMAN	ribonuclease, RNase A family, 7 precursor	64					defense response to bacterium|innate immune response	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CACACAAAACGGTGCAAAGAC	0.502													1	0	6.32553e-13	0.004656	6.89139e-13	25	80										T	21511342	G	T	21511342	3	4	80	1	0	0	0	0	1	0	0	0	13408	1116	39	4	193	4	RNASE7	14	21511342	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		21511342	85838198	162	24050										
LRP10	26020	broad.mit.edu	37	chr14	23346425	23346425	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagtgggtgggcaagatgggGagcaggcacccccactgccc	16	13	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:23346425G>T	uc001whd.2	+	7	2384	c.1831G>T	c.(1831-1833)GAG>TAG	p.E611*	LRP10_uc001whe.2_Intron	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	611	Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GCAAGATGGGGAGCAGGCACC	0.667													1	0	4.96729e-08	0.008871	5.30986e-08	21	58										T	23346425	G	T	23346425	4	4	80	1	0	0	0	0	0	1	0	0	8952	1175	41	3	1857	3	LRP10	14	23346425	Nonsense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1835083	23346425	84003115	163	24051										
PRKD1	5587	broad.mit.edu	37	chr14	30098274	30098274	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcttgaatctggcaatttgaTactgaaatactcacagagat	7	7	3	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:30098274T>C	uc001wqh.2	-	11	1879	c.1698A>G	c.(1696-1698)GTA>GTG	p.V566V		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	566					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGCAATTTGATACTGAAATAC	0.299													0	0	0	0.004656	0	24	62										C	30098274	T	C	30098274	2	2	80	1	0	0	0	0	0	0	0	1	12518	1393	49	5		5	PRKD1	14	30098274	Silent	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	6751849	30098274	77251266	164	24052										
COCH	1690	broad.mit.edu	37	chr14	31355167	31355167	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cctttctaattgatggctccAgcagtgttggagatagcaat	10	8	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:31355167A>T	uc001wqr.2	+	11	1206	c.1126A>T	c.(1126-1128)AGC>TGC	p.S376C	COCH_uc001wqp.2_Missense_Mutation_p.S376C|COCH_uc001wqq.3_Missense_Mutation_p.S376C|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.S227C	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	376	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TGATGGCTCCAGCAGTGTTGG	0.438													0	0	0	0.009535	0	32	64										T	31355167	A	T	31355167	3	4	80	1	0	0	0	0	1	0	0	0	3656	188	7	5	1164	5	COCH	14	31355167	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	1256893	31355167	75994373	165	24053										
NUBPL	80224	broad.mit.edu	37	chr14	32031321	32031321	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aaacaaagaagaacacaaatCatgtcccgaggacttccaaa	6	10	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:32031321C>T	uc001wrk.3	+	2	211	c.156C>T	c.(154-156)ATC>ATT	p.I52I	NUBPL_uc010amj.2_RNA	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	52					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		GAACACAAATCATGTCCCGAG	0.398													0	0	0	0.001168	0	6	24										T	32031321	C	T	32031321	2	4	80	1	0	0	0	0	0	0	0	1	10717	816	29	1		1	NUBPL	14	32031321	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	676154	32031321	75318219	166	24054										
FOXA1	3169	broad.mit.edu	37	chr14	38061854	38061862	+	In_Frame_Del	DEL	GTTCATGGA	GTTCATGGA	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtgttcatggtcatgtaggtGttcatggagttcatggagcc							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			GTTCATGGA	-	GTTCATGGA	GTTCATGGA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:38061854_38061862delGTTCATGGA	uc001wuf.2	-	2	439_447	c.127_135delTCCATGAAC	c.(127-135)TCCATGAACdel	p.SMN43del	FOXA1_uc010tpz.1_In_Frame_Del_p.SMN10del	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	43_45					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TCATGTAGGTGTTCATGGAGTTCATGGAG	0.608																		21	89	---	---								-	38061862	GTTCATGGA	-	38061854	7	5	80	1	0	1	0	1	0	0	0	0	5989	1368	48	0	1287	0	FOXA1	14	38061854	In_Frame_Del	DEL	GTTCATGGA	TCGA-FD-A3SL-01A-21D-A22Z-08	6030533	38061854	69287686	167	24055										
MIA2	117153	broad.mit.edu	37	chr14	39716256	39716256	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtatatatgaaagtgattttCagatagaacctggattttat	8	3	1	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:39716256C>A	uc001wux.2	+	4	672	c.478C>A	c.(478-480)CAG>AAG	p.Q160K	MIA2_uc010amy.1_Missense_Mutation_p.Q91K	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	160						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		AAGTGATTTTCAGATAGAACC	0.323													1	0	7.92952e-12	0.003954	8.55686e-12	26	53										A	39716256	C	A	39716256	3	1	80	1	0	0	0	0	1	0	0	0	9564	827	29	3	492	3	MIA2	14	39716256	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1654402	39716256	67633284	168	24056										
ZC3H14	79882	broad.mit.edu	37	chr14	89069337	89069337	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aacaagggactcagaggtctCctccacccacagcagttgca	9	14	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:89069337C>G	uc001xww.2	+	12	1905	c.1680C>G	c.(1678-1680)CTC>CTG	p.L560L	ZC3H14_uc010twd.1_Silent_p.L560L|ZC3H14_uc010twe.1_Silent_p.L560L|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Intron|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Silent_p.L105L|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Intron	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	560						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCAGAGGTCTCCTCCACCCAC	0.512													0	0	0	0.00499	0	15	45										G	89069337	C	G	89069337	2	3	80	1	0	0	0	0	0	0	0	1	17563	842	30	1		1	ZC3H14	14	89069337	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	49353081	89069337	18280203	169	24057										
GPR68	8111	broad.mit.edu	37	chr14	91700960	91700960	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtcagcagctccttggcccaGatgaccacgctgacgccgac	11	16	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:91700960G>A	uc001xzg.2	-	2	776	c.435C>T	c.(433-435)ATC>ATT	p.I145I	GPR68_uc001xzh.2_Silent_p.I155I	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	145	Helical; Name=4; (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		CCTTGGCCCAGATGACCACGC	0.627													0	0	0	0.006214	0	9	32										A	91700960	G	A	91700960	2	1	80	1	0	0	0	0	0	0	0	1	6707	932	33	1		1	GPR68	14	91700960	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	2631623	91700960	15648580	170	24058										
NUDT14	256281	broad.mit.edu	37	chr14	105642983	105642983	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cccaggctggtccacgaggcCggcacacagctcaactgtca	11	16	2	0	rs138979378		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:105642983C>G	uc010tyn.1	-	4	430	c.316G>C	c.(316-318)GGC>CGC	p.G106R	NUDT14_uc001yqi.2_RNA	NM_177533	NP_803877	O95848	NUD14_HUMAN	nudix-type motif 14	106	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			skin(1)	1		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCCACGAGGCCGGCACACAGC	0.677										HNSCC(42;0.11)			0	0	0	0.006122	0	19	60										G	105642983	C	G	105642983	3	3	80	1	0	0	0	0	1	0	0	0	10730	652	23	4	360	4	NUDT14	14	105642983	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	13942023	105642983	1706557	171	24059										
TJP1	7082	broad.mit.edu	37	chr15	30010801	30010801	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tggactctgcaggcttgggcCctgctgaagggtggggctgg	19	9	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:30010801C>A	uc001zcr.2	-	21	4020	c.3545G>T	c.(3544-3546)GGG>GTG	p.G1182V	TJP1_uc010azl.2_Missense_Mutation_p.G1170V|TJP1_uc001zcq.2_Missense_Mutation_p.G1106V|TJP1_uc001zcs.2_Missense_Mutation_p.G1102V	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1182					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AGGCTTGGGCCCTGCTGAAGG	0.557													1	0	7.87624e-14	0.00278	8.69191e-14	23	66										A	30010801	C	A	30010801	3	1	80	1	0	0	0	0	1	0	0	0	15926	623	22	4	1733	4	TJP1	15	30010801	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		30010801	72520591	172	24060										
SLC12A6	9990	broad.mit.edu	37	chr15	34628777	34628777	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cgggaactagatcgagagctGaggtccggactggtgtctga	16	8	1	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:34628777G>A	uc001zhw.2	-	1	269	c.105C>T	c.(103-105)CTC>CTT	p.L35L	SLC12A6_uc001zhx.2_Silent_p.L35L|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_5'UTR|SLC12A6_uc001zib.2_Silent_p.L26L|SLC12A6_uc001zic.2_Silent_p.L35L|SLC12A6_uc010bau.2_Silent_p.L35L|SLC12A6_uc001zid.2_5'UTR	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	35	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	ATCGAGAGCTGAGGTCCGGAC	0.527													0	0	0	0.006122	0	14	54										A	34628777	G	A	34628777	2	1	80	1	0	0	0	0	0	0	0	1	14387	1277	45	1		1	SLC12A6	15	34628777	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	4617976	34628777	67902615	173	24061										
MFAP1	4236	broad.mit.edu	37	chr15	44109632	44109632	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acgctttaccttcactttttCcattgaaatctcacctgggc	5	13	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:44109632C>T	uc001zth.1	-	2	278	c.94G>A	c.(94-96)GAA>AAA	p.E32K		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	32						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TTCACTTTTTCCATTGAAATC	0.433													0	0	0	0.008361	0	28	68										T	44109632	C	T	44109632	3	4	80	1	0	0	0	0	1	0	0	0	9513	864	30	1	1257	1	MFAP1	15	44109632	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	9480855	44109632	58421760	174	24062										
SECISBP2L	9728	broad.mit.edu	37	chr15	49320761	49320761	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atgtcggcttcactagccccCtgctcactagaagattcagc	8	14	3	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:49320761C>G	uc001zxe.1	-	5	917	c.783G>C	c.(781-783)CAG>CAC	p.Q261H	SECISBP2L_uc001zxd.1_Missense_Mutation_p.Q261H|SECISBP2L_uc010bep.1_Missense_Mutation_p.Q23H|SECISBP2L_uc010beq.1_Intron	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	261										breast(1)|skin(1)	2						CACTAGCCCCCTGCTCACTAG	0.512													0	0	0	0.008361	0	31	87										G	49320761	C	G	49320761	3	3	80	1	0	0	0	0	1	0	0	0	14007	680	24	4	2439	4	SECISBP2L	15	49320761	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	5211129	49320761	53210631	175	24063										
VPS13C	54832	broad.mit.edu	37	chr15	62182381	62182381	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tacctggttatcccaatataGgaaacttcctgcttgctttc	6	11	0	0	rs113570828		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:62182381G>A	uc002agz.2	-	67	9398	c.9324C>T	c.(9322-9324)TCC>TCT	p.S3108S	VPS13C_uc002aha.2_Silent_p.S3065S|VPS13C_uc002ahb.1_Silent_p.S3108S|VPS13C_uc002ahc.1_Silent_p.S3065S	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3108					protein localization					ovary(2)	2						TCCCAATATAGGAAACTTCCT	0.373													0	0	0	0.008871	0	19	50										A	62182381	G	A	62182381	2	1	80	1	0	0	0	0	0	0	0	1	17188	987	35	2		2	VPS13C	15	62182381	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	12861620	62182381	40349011	176	24064										
RAB8B	51762	broad.mit.edu	37	chr15	63541870	63541870	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agcgggtcaggaaagattccGaacaatcacgacagcgtact	11	10	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:63541870G>A	uc002alz.2	+	3	308	c.212G>A	c.(211-213)CGA>CAA	p.R71Q	RAB8B_uc010uih.1_Missense_Mutation_p.R71Q	NM_016530	NP_057614	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	71					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)|kidney(1)	2						GAAAGATTCCGAACAATCACG	0.448													0	0	0	0.010729	0	9	25										A	63541870	G	A	63541870	3	1	80	1	0	0	0	0	1	0	0	0	12957	1058	37	1	222	1	RAB8B	15	63541870	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1359489	63541870	38989522	177	24065										
HERC1	8925	broad.mit.edu	37	chr15	63970149	63970149	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagtttgcttgtgaacacacCgacctccaactctaagacca	6	14	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:63970149C>G	uc002amp.2	-	37	7113	c.6965G>C	c.(6964-6966)CGG>CCG	p.R2322P		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2322					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GTGAACACACCGACCTCCAAC	0.557													0	0	0	0.010818	0	31	91										G	63970149	C	G	63970149	3	3	80	1	0	0	0	0	1	0	0	0	7057	652	23	4	7788	4	HERC1	15	63970149	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	428279	63970149	38561243	178	24066										
KIAA1024	23251	broad.mit.edu	37	chr15	79750750	79750750	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggagataaaagacacaggccCaggagataataaagactggc	12	7	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:79750750C>T	uc002bew.1	+	2	2336	c.2261C>T	c.(2260-2262)CCA>CTA	p.P754L	KIAA1024_uc010unk.1_Missense_Mutation_p.P754L	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	754						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GACACAGGCCCAGGAGATAAT	0.453													0	0	0	0.006122	0	17	63										T	79750750	C	T	79750750	3	4	80	1	0	0	0	0	1	0	0	0	8205	594	21	2	2263	2	KIAA1024	15	79750750	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	15780601	79750750	22780642	179	24067										
SELS	55829	broad.mit.edu	37	chr15	101813019	101813019	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggcctctgcgtccaggtctcCaggagcaagctccgcctcct	11	17	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:101813019C>T	uc010use.1	-	6	605	c.527G>A	c.(526-528)TGG>TAG	p.W176*	SELS_uc010usf.1_Nonsense_Mutation_p.W176*	NM_203472	NP_982298	Q9BQE4	SELS_HUMAN	selenoprotein S	176					anti-apoptosis|cell redox homeostasis|cellular response to insulin stimulus|cellular response to lipopolysaccharide|cellular response to oxidative stress|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|negative regulation of acute inflammatory response to antigenic stimulus|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of interleukin-6 production|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of tumor necrosis factor production|regulation of gluconeogenesis|regulation of nitric oxide metabolic process|response to glucose stimulus|response to redox state|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane|low-density lipoprotein particle|microsome|plasma membrane|very-low-density lipoprotein particle	antioxidant activity|enzyme binding|receptor activity|selenium binding				0	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCCAGGTCTCCAGGAGCAAGC	0.478													0	0	0	0.000602	0	5	13										T	101813019	C	T	101813019	4	4	80	1	0	0	0	0	0	1	0	0	14021	595	21	2	46	2	SELS	15	101813019	Nonsense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	22062269	101813019	718373	180	24068										
CACNA1H	8912	broad.mit.edu	37	chr16	1248648	1248648	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtcactctgctgctggataCgctgcccatgctcgggaacg	13	13	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:1248648C>T	uc002cks.2	+	6	925	c.677C>T	c.(676-678)ACG>ATG	p.T226M	CACNA1H_uc002ckt.2_Missense_Mutation_p.T226M	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	226	Cytoplasmic (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ctgctggatacgctgcccatg	0.478													0	0	0	0.009718	0	40	70										T	1248648	C	T	1248648	3	4	80	1	0	0	0	0	1	0	0	0	2545	536	19	2	695	2	CACNA1H	16	1248648	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		1248648	89106105	181	24069										
MRPS34	65993	broad.mit.edu	37	chr16	1822451	1822451	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aggcctcctcctcgtgcttgGgcaccagccgccagtcatgg	12	16	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:1822451G>C	uc002cmo.2	-	3	448	c.428C>G	c.(427-429)CCC>CGC	p.P143R	NME3_uc002cmm.2_5'Flank|NME3_uc010brv.2_5'Flank|MRPS34_uc002cmn.2_Missense_Mutation_p.P9R|MRPS34_uc002cmp.1_Missense_Mutation_p.P150R|EME2_uc002cmq.1_5'Flank|EME2_uc010brw.1_5'Flank	NM_023936	NP_076425	P82930	RT34_HUMAN	mitochondrial ribosomal protein S34	143						mitochondrion|ribosome	protein binding			skin(2)	2						CTCGTGCTTGGGCACCAGCCG	0.627													0	0	0	0.004289	0	33	114										C	1822451	G	C	1822451	3	2	80	1	0	0	0	0	1	0	0	0	9843	1232	43	4	232	4	MRPS34	16	1822451	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	573803	1822451	88532302	182	24070										
ZSCAN10	84891	broad.mit.edu	37	chr16	3139752	3139752	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tggctgaccagctgcgagctCtgcgtgaagctgcggccgca	15	13	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:3139752C>G	uc002ctv.1	-	5	1606	c.1518G>C	c.(1516-1518)CAG>CAC	p.Q506H	ZSCAN10_uc002cty.1_Missense_Mutation_p.Q167H|ZSCAN10_uc002ctw.1_Missense_Mutation_p.Q424H|ZSCAN10_uc002ctx.1_Missense_Mutation_p.Q434H	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	506	C2H2-type 7.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GCTGCGAGCTCTGCGTGAAGC	0.716													0	0	0	0.001984	0	7	4										G	3139752	C	G	3139752	3	3	80	1	0	0	0	0	1	0	0	0	18224	912	32	1	663	1	ZSCAN10	16	3139752	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1317301	3139752	87215001	183	24071										
CREBBP	1387	broad.mit.edu	37	chr16	3788651	3788651	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccggaagaaatgaatactatCcagataagaaatgtacacac	7	8	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:3788651C>G	uc002cvv.2	-	26	4507	c.4303G>C	c.(4303-4305)GAT>CAT	p.D1435H	CREBBP_uc002cvw.2_Missense_Mutation_p.D1397H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1435	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1435G(1)|p.D1435E(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGAATACTATCCAGATAAGAA	0.433			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.010729	0	12	19										G	3788651	C	G	3788651	3	3	80	1	0	0	0	0	1	0	0	0	3861	855	30	1	3049	1	CREBBP	16	3788651	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	648899	3788651	86566102	184	24072										
NMRAL1	57407	broad.mit.edu	37	chr16	4511813	4511813	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaagtcccctttgtgctgttCcagccactggtccagcgtca	10	14	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:4511813C>A	uc002cwm.2	-	6	1024	c.868G>T	c.(868-870)GAA>TAA	p.E290*	NMRAL1_uc002cwn.2_Nonsense_Mutation_p.E290*|NMRAL1_uc002cwo.2_Nonsense_Mutation_p.E290*|NMRAL1_uc002cwp.2_Nonsense_Mutation_p.E326*	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	290						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						TTGTGCTGTTCCAGCCACTGG	0.622													1	0	5.20006e-24	0.011902	5.91074e-24	46	81										A	4511813	C	A	4511813	4	1	80	1	0	0	0	0	0	1	0	0	10501	864	30	3	35	3	NMRAL1	16	4511813	Nonsense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	723162	4511813	85842940	185	24073										
SEZ6L2	26470	broad.mit.edu	37	chr16	29908193	29908193	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tcgtggtgatgatggtggtcGtcgtctcctcctctcctccc	11	14	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:29908193G>A	uc002duq.3	-	3	701	c.461C>T	c.(460-462)ACG>ATG	p.T154M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.T84M|SEZ6L2_uc002dur.3_Missense_Mutation_p.T84M|SEZ6L2_uc002dus.3_Missense_Mutation_p.T154M|SEZ6L2_uc010vec.1_Missense_Mutation_p.T154M|SEZ6L2_uc010ved.1_Missense_Mutation_p.T110M	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	154	Thr-rich.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GATGGTGGTCGTCGTCTCCTC	0.672													0	0	0	0.005443	0	21	43										A	29908193	G	A	29908193	3	1	80	1	0	0	0	0	1	0	0	0	14144	1145	40	2	2374	2	SEZ6L2	16	29908193	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	25396380	29908193	60446560	186	24074										
CORO1A	11151	broad.mit.edu	37	chr16	30198259	30198260	+	Frame_Shift_Ins	INS	-	-	T													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cagcccagaacgtgctgctcINSagtgcaggtgctgcgggagg							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:30198259_30198260insT	uc002dww.2	+	4	566_567	c.444_445insT	c.(442-447)CTCAGTfs	p.L148fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010vej.1_Frame_Shift_Ins_p.L148fs|CORO1A_uc010bzq.2_Frame_Shift_Ins_p.L148fs|CORO1A_uc010bzr.2_Frame_Shift_Ins_p.L148fs|CORO1A_uc002dwx.2_Frame_Shift_Ins_p.L42fs|CORO1A_uc002dwy.1_5'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	148_149	WD 3.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						ACGTGCTGCTCAGTGCAGGTGC	0.673																		11	42	---	---								T	30198260	-	T	30198259	7	5	80	1	0	1	1	0	0	0	0	0	3753	813	29	0	454	0	CORO1A	16	30198259	Frame_Shift_Ins	INS	-	TCGA-FD-A3SL-01A-21D-A22Z-08	290066	30198259	60156494	187	24075										
VPS35	55737	broad.mit.edu	37	chr16	46705699	46705699	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctcatcagcaaaatcttctGgatcagggtcttctacaggt	9	10	7	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:46705699G>A	uc002eef.3	-	12	1541	c.1442C>T	c.(1441-1443)CCA>CTA	p.P481L	VPS35_uc002eed.2_Missense_Mutation_p.P302L|VPS35_uc002eee.2_Missense_Mutation_p.P442L	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	481					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				AAAATCTTCTGGATCAGGGTC	0.483													0	0	0	0.003163	0	16	33										A	46705699	G	A	46705699	3	1	80	1	0	0	0	0	1	0	0	0	17200	1348	47	2	972	2	VPS35	16	46705699	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	16507440	46705699	43649054	188	24076										
ABCC11	85320	broad.mit.edu	37	chr16	48244929	48244929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cttcttcctctggcccgaggGcatctctaggcctggtcatc	10	15	4	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:48244929G>A	uc002eff.1	-	10	1888	c.1538C>T	c.(1537-1539)GCC>GTC	p.A513V	ABCC11_uc002efg.1_Missense_Mutation_p.A513V|ABCC11_uc002efh.1_Missense_Mutation_p.A513V|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	513	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGGCCCGAGGGCATCTCTAGG	0.607									Cerumen_Type				0	0	0	0.007413	0	20	54										A	48244929	G	A	48244929	3	1	80	1	0	0	0	0	1	0	0	0	51	1203	42	2	2690	2	ABCC11	16	48244929	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1539230	48244929	42109824	189	24077										
SLC12A3	6559	broad.mit.edu	37	chr16	56921870	56921870	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggagaatgaagcccaacattCtggtggttgggttcaagaag	14	6	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:56921870C>G	uc010ccm.2	+	18	2241	c.2212C>G	c.(2212-2214)CTG>GTG	p.L738V	SLC12A3_uc002ekd.3_Missense_Mutation_p.L738V|SLC12A3_uc010ccn.2_Missense_Mutation_p.L737V	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	738	Cytoplasmic (Potential).		L -> R (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCCCAACATTCTGGTGGTTGG	0.602													0	0	0	0.012319	0	20	44										G	56921870	C	G	56921870	3	3	80	1	0	0	0	0	1	0	0	0	14384	912	32	1	2282	1	SLC12A3	16	56921870	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	8676941	56921870	33432883	190	24078										
CDH16	1014	broad.mit.edu	37	chr16	66944399	66944399	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtgcagaagcgctcagtctcGgctcatctgcagaggaggca	14	11	4	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:66944399G>C	uc002eql.2	-	15	2004	c.1931C>G	c.(1930-1932)CCG>CGG	p.P644R	CDH16_uc010cdy.2_Intron|CDH16_uc002eqm.2_Missense_Mutation_p.P547R	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	644	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCTCAGTCTCGGCTCATCTGC	0.652													0	0	0	0.005443	0	26	48										C	66944399	G	C	66944399	3	2	80	1	0	0	0	0	1	0	0	0	3101	1116	39	4	574	4	CDH16	16	66944399	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	10022529	66944399	23410354	191	24079										
FBXL8	55336	broad.mit.edu	37	chr16	67197579	67197579	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaggagctggcggcgcgctgCgcggccctgcgcgaggtgca	20	13	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:67197579C>T	uc002erj.1	+	3	1101	c.981C>T	c.(979-981)TGC>TGT	p.C327C	FBXL8_uc002erk.1_Silent_p.C327C|HSF4_uc002erl.1_5'UTR|HSF4_uc002erm.1_5'UTR|HSF4_uc002ern.1_5'Flank|HSF4_uc010cec.1_5'Flank	NM_018378	NP_060848	Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	327							protein binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		CGGCGCGCTGCGCGGCCCTGC	0.716													0	0	0	0.006214	0	10	14										T	67197579	C	T	67197579	2	4	80	1	0	0	0	0	0	0	0	1	5725	776	27	2		2	FBXL8	16	67197579	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	253180	67197579	23157174	192	24080										
NFAT5	10725	broad.mit.edu	37	chr16	69726188	69726188	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gacttggtccaacaagttttAgaggcacagcagcagttatc	10	9	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:69726188A>C	uc002exm.1	+	12	3614	c.2406A>C	c.(2404-2406)TTA>TTC	p.L802F	NFAT5_uc002exi.2_Missense_Mutation_p.L726F|NFAT5_uc002exj.1_Missense_Mutation_p.L726F|NFAT5_uc002exk.1_Missense_Mutation_p.L726F|NFAT5_uc002exl.1_Missense_Mutation_p.L820F|NFAT5_uc002exn.1_Missense_Mutation_p.L819F|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	802					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AACAAGTTTTAGAGGCACAGC	0.438													0	0	0	0.007291	0	29	119										C	69726188	A	C	69726188	3	2	80	1	0	0	0	0	1	0	0	0	10360	417	15	5	2510	5	NFAT5	16	69726188	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	2528609	69726188	20628565	193	24081										
ZNF276	92822	broad.mit.edu	37	chr16	89789221	89789221	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtcaacgcctccccggctgGtcgccggaagccttgtgcaa	13	15	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:89789221G>C	uc002fos.3	+	2	585	c.488G>C	c.(487-489)GGT>GCT	p.G163A	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.G88A|ZNF276_uc002foq.3_Missense_Mutation_p.G88A|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TCCCCGGCTGGTCGCCGGAAG	0.592													0	0	0	0.004007	0	17	59										C	89789221	G	C	89789221	3	2	80	1	0	0	0	0	1	0	0	0	17808	1261	44	4	494	4	ZNF276	16	89789221	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	20063033	89789221	565532	194	24082										
OR3A1	4994	broad.mit.edu	37	chr17	3194930	3194930	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agggtcaattgagacctcctCaagccagtgaccgcctccct	9	15	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:3194930C>G	uc002fvh.1	-	1	947	c.947G>C	c.(946-948)TGA>TCA	p.*316S		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	316					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						GAGACCTCCTCAAGCCAGTGA	0.473													0	0	0	0.001855	0	13	56										G	3194930	C	G	3194930	4	3	80	1	0	0	0	0	0	0	0	0	11037	840	29	1	4	1	OR3A1	17	3194930	Nonstop_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08		3194930	78000280	195	24083										
ZZEF1	23140	broad.mit.edu	37	chr17	3957435	3957435	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggcaatctcatcacacccatCacaagagatgtccacattta	5	13	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:3957435C>T	uc002fxe.2	-	34	5414	c.5350G>A	c.(5350-5352)GAT>AAT	p.D1784N	ZZEF1_uc002fxh.2_Missense_Mutation_p.D98N|ZZEF1_uc002fxi.2_Missense_Mutation_p.D19N|ZZEF1_uc002fxj.1_Missense_Mutation_p.D397N	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1784	ZZ-type 1.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCACACCCATCACAAGAGATG	0.438													0	0	0	0.003163	0	16	77										T	3957435	C	T	3957435	3	4	80	1	0	0	0	0	1	0	0	0	18252	826	29	1	3623	1	ZZEF1	17	3957435	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	762505	3957435	77237775	196	24084										
CHRNE	1145	broad.mit.edu	37	chr17	4805975	4805975	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtgacagtatcctcaggctCccgcactggccggcttcctg	12	15	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:4805975C>T	uc002fzk.1	-	2	141	c.130G>A	c.(130-132)GAG>AAG	p.E44K	C17orf107_uc002fzl.3_3'UTR	NM_000080	NP_000071	Q04844	ACHE_HUMAN	nicotinic acetylcholine receptor epsilon	44	Extracellular (Potential).				muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TCCTCAGGCTCCCGCACTGGC	0.542													0	0	0	0.01441	0	60	109										T	4805975	C	T	4805975	3	4	80	1	0	0	0	0	1	0	0	0	3395	864	30	1	1395	1	CHRNE	17	4805975	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	848540	4805975	76389235	197	24085										
TP53	7157	broad.mit.edu	37	chr17	7577079	7577079	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccctttcttgcggagattctCttcctctgtgcgccggtctc	9	15	4	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:7577079C>A	uc002gim.2	-	8	1053	c.859G>T	c.(859-861)GAG>TAG	p.E287*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E287*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E155*|TP53_uc010cng.1_Nonsense_Mutation_p.E155*|TP53_uc002gii.1_Nonsense_Mutation_p.E155*|TP53_uc010cnh.1_Nonsense_Mutation_p.E287*|TP53_uc010cni.1_Nonsense_Mutation_p.E287*|TP53_uc002gij.2_Nonsense_Mutation_p.E287*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	287	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N288fs*13(17)|p.E287*(8)|p.0?(7)|p.E287K(6)|p.E287E(5)|p.E287G(2)|p.E287D(2)|p.?(2)|p.R283fs*16(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.E287V(1)|p.E287fs*17(1)|p.E287A(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGAGATTCTCTTCCTCTGTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	3.62473e-10	0.012319	3.89916e-10	22	21										A	7577079	C	A	7577079	4	1	80	1	0	0	0	0	0	1	0	0	16378	922	32	3	427	3	TP53	17	7577079	Nonsense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	2771104	7577079	73618131	198	24086										
NCOR1	9611	broad.mit.edu	37	chr17	15973488	15973488	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aagtaacataccatcagaagTtctgttcatcatgggtgagc	9	8	4	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:15973488T>A	uc002gpo.2	-	31	4744	c.4504A>T	c.(4504-4506)ACT>TCT	p.T1502S	NCOR1_uc002gpn.2_Missense_Mutation_p.T1518S|NCOR1_uc002gpp.1_Missense_Mutation_p.T1409S|NCOR1_uc002gpm.2_5'Flank|NCOR1_uc010vwb.1_Missense_Mutation_p.T86S|NCOR1_uc010coy.2_Missense_Mutation_p.T410S|NCOR1_uc010vwc.1_Missense_Mutation_p.T313S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1502	Interaction with ETO.|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CCATCAGAAGTTCTGTTCATC	0.383													0	0	0	0.00623	0	36	151										A	15973488	T	A	15973488	3	1	80	1	0	0	0	0	1	0	0	0	10235	1725	60	5	2882	5	NCOR1	17	15973488	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	8396409	15973488	65221722	199	24087										
TOP3A	7156	broad.mit.edu	37	chr17	18181485	18181485	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcaggctgggggtgctggctGttgtccatcctgttcaggga	17	9	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:18181485G>A	uc002gsx.1	-	18	2560	c.2331C>T	c.(2329-2331)AAC>AAT	p.N777N	TOP3A_uc010cpz.1_Silent_p.N229N|TOP3A_uc010vxr.1_Silent_p.N307N|TOP3A_uc002gsw.1_Silent_p.N229N|TOP3A_uc010vxs.1_Silent_p.N675N	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	777					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GGTGCTGGCTGTTGTCCATCC	0.632													0	0	0	0.012319	0	20	92										A	18181485	G	A	18181485	2	1	80	1	0	0	0	0	0	0	0	1	16364	1368	48	2		2	TOP3A	17	18181485	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	2207997	18181485	63013725	200	24088										
TRIM16L	147166	broad.mit.edu	37	chr17	18638504	18638504	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tccaatggaacgggaaggagTtcacggcctggtacagtgac	14	9	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:18638504T>A	uc002gug.1	+	10	1465	c.778T>A	c.(778-780)TTC>ATC	p.F260I	TRIM16L_uc010vyf.1_Missense_Mutation_p.F314I|TRIM16L_uc002guh.1_Missense_Mutation_p.F260I|TRIM16L_uc010cqg.1_Missense_Mutation_p.F362I|TRIM16L_uc002gui.1_Missense_Mutation_p.F260I|TRIM16L_uc010vyg.1_Missense_Mutation_p.F260I|TRIM16L_uc010vyh.1_3'UTR	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	260	B30.2/SPRY.					cytoplasm					0						CGGGAAGGAGTTCACGGCCTG	0.557													0	0	0	0.00499	0	13	82										A	18638504	T	A	18638504	3	1	80	1	0	0	0	0	1	0	0	0	16489	1725	60	5	792	5	TRIM16L	17	18638504	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	457019	18638504	62556706	201	24089										
FBXL20	84961	broad.mit.edu	37	chr17	37427047	37427047	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggaacctaaagaaaatacttAccctggctagagtggtaaag	10	7	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:37427047A>T	uc010wed.1	-	11	1109	c.888_splice	c.e11+1	p.R296_splice	FBXL20_uc002hrt.2_Splice_Site_p.R296_splice|FBXL20_uc010cvu.2_Splice_Site_p.R264_splice	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20							cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			GAAAATACTTACCCTGGCTAG	0.358													0	0	0	0.008871	0	17	17										T	37427047	A	T	37427047	5	4	80	1	0	0	0	0	0	0	1	0	5717	405	14	5	440	5	FBXL20	17	37427047	Splice_Site	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	18788543	37427047	43768163	202	24090										
KIAA1267	284058	broad.mit.edu	37	chr17	44248600	44248600	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggcttgcacaacctgtaagcGcttttgtaatctgcgggcac	11	11	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:44248600G>C	uc002ikb.2	-	1	995	c.910C>G	c.(910-912)CGC>GGC	p.R304G	KIAA1267_uc002ikc.2_Missense_Mutation_p.R304G|KIAA1267_uc002ikd.2_Missense_Mutation_p.R304G|KIAA1267_uc010dav.2_Missense_Mutation_p.R304G	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	304	Potential.					MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				ACCTGTAAGCGCTTTTGTAAT	0.468													0	0	0	0.014323	0	23	143										C	44248600	G	C	44248600	3	2	80	1	0	0	0	0	1	0	0	0	8219	1087	38	4	2463	4	KIAA1267	17	44248600	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	6821553	44248600	36946610	203	24091										
TLK2	11011	broad.mit.edu	37	chr17	60654136	60654136	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agattaggtcatcttaaaaaGgtaagtataatgagaaaatc	8	3	2	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:60654136G>C	uc010ddp.2	+	14	1522	c.1254G>C	c.(1252-1254)AAG>AAC	p.K418N	TLK2_uc002izx.3_Missense_Mutation_p.K244N|TLK2_uc002izz.3_Missense_Mutation_p.K396N|TLK2_uc002jaa.3_Missense_Mutation_p.K364N|TLK2_uc010wpd.1_Missense_Mutation_p.K364N	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	418	Potential.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						ATCTTAAAAAGGTAAGTATAA	0.343													0	0	0	0.01441	0	59	40										C	60654136	G	C	60654136	3	2	80	1	0	0	0	0	1	0	0	0	15941	1014	35	4	1234	4	TLK2	17	60654136	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	16405536	60654136	20541074	204	24092										
PRKCA	5578	broad.mit.edu	37	chr17	64299005	64299005	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccgggcaacgactccacggcGtctcaggacgtggccaaccg	13	16	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:64299005G>A	uc002jfp.1	+	1	80	c.36G>A	c.(34-36)GCG>GCA	p.A12A	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	12					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ACTCCACGGCGTCTCAGGACG	0.602													0	0	0	0.006122	0	19	27										A	64299005	G	A	64299005	2	1	80	1	0	0	0	0	0	0	0	1	12507	1132	40	2		2	PRKCA	17	64299005	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3644869	64299005	16896205	205	24093										
CASKIN2	57513	broad.mit.edu	37	chr17	73498037	73498037	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggctggaaggctgctgggctCgggctggggaaggctagaag	21	7	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:73498037C>T	uc002joc.2	-	18	3668	c.3118G>A	c.(3118-3120)GAG>AAG	p.E1040K	CASKIN2_uc010wsc.1_Missense_Mutation_p.E958K	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1040	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGCTGGGCTCGGGCTGGGGA	0.697													0	0	0	0.007291	0	29	57										T	73498037	C	T	73498037	3	4	80	1	0	0	0	0	1	0	0	0	2667	893	31	1	502	1	CASKIN2	17	73498037	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	9199032	73498037	7697173	206	24094										
ZNF750	79755	broad.mit.edu	37	chr17	80789041	80789042	+	Frame_Shift_Ins	INS	-	-	A													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccttgttggagaggtcgtacINSaggccttcgcaggtctggct							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:80789041_80789042insA	uc002kga.2	-	2	1600_1601	c.1289_1290insT	c.(1288-1290)CTGfs	p.L430fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	430						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGAGGTCGTACAGGCCTTCGCA	0.624																		24	86	---	---								A	80789042	-	A	80789041	7	5	80	1	0	1	1	0	0	0	0	0	18129	465	17	0	889	0	ZNF750	17	80789041	Frame_Shift_Ins	INS	-	TCGA-FD-A3SL-01A-21D-A22Z-08	7291004	80789041	406169	207	24095										
EPB41L3	23136	broad.mit.edu	37	chr18	5406924	5406928	+	Frame_Shift_Del	DEL	TTGGT	TTGGT	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ttcttttcagctcgctaatgTtggtttgatgtttcatcagg							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:5406924_5406928delTTGGT	uc002kmt.1	-	16	2283_2287	c.2197_2201delACCAA	c.(2197-2202)ACCAACfs	p.T733fs	EPB41L3_uc010wzh.1_Frame_Shift_Del_p.T564fs|EPB41L3_uc002kmu.1_Frame_Shift_Del_p.T552fs|EPB41L3_uc010dkq.1_Frame_Shift_Del_p.T443fs|EPB41L3_uc002kms.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010wze.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010wzf.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010wzg.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010dkr.2_Frame_Shift_Del_p.T125fs	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	733_734	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CTCGCTAATGTTGGTTTGATGTTTC	0.429																		31	100	---	---								-	5406928	TTGGT	-	5406924	7	5	80	1	0	1	0	1	0	0	0	0	5154	1725	60	0	1090	0	EPB41L3	18	5406924	Frame_Shift_Del	DEL	TTGGT	TCGA-FD-A3SL-01A-21D-A22Z-08		5406924	72670324	208	24096										
ARHGAP28	79822	broad.mit.edu	37	chr18	6890047	6890047	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aaacactgcggcccacatcaTccgcctaatgcttaagtacc	6	15	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:6890047T>A	uc010wzi.1	+	12	1404	c.1166T>A	c.(1165-1167)ATC>AAC	p.I389N	ARHGAP28_uc002knc.2_Missense_Mutation_p.I514N|ARHGAP28_uc002knd.2_Missense_Mutation_p.I407N|ARHGAP28_uc002kne.2_Missense_Mutation_p.I407N|ARHGAP28_uc002knf.2_Missense_Mutation_p.I398N			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	389					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				GCCCACATCATCCGCCTAATG	0.443													0	0	0	0.01441	0	47	98										A	6890047	T	A	6890047	3	1	80	1	0	0	0	0	1	0	0	0	877	1435	50	5	1262	5	ARHGAP28	18	6890047	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	1483123	6890047	71187201	209	24097										
ANKRD29	147463	broad.mit.edu	37	chr18	21226188	21226188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gatgtctgctccttgcagaaCcagttccctcacacagtcta	7	14	3	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:21226188C>T	uc002kun.2	-	3	353	c.196G>A	c.(196-198)GTT>ATT	p.V66I	ANKRD29_uc002kuo.2_Missense_Mutation_p.V66I	NM_173505	NP_775776	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	66	ANK 2.									ovary(3)|breast(1)	4	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCTTGCAGAACCAGTTCCCTC	0.498													0	0	0	0.004007	0	15	43										T	21226188	C	T	21226188	3	4	80	1	0	0	0	0	1	0	0	0	657	507	18	2	741	2	ANKRD29	18	21226188	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	14336141	21226188	56851060	210	24098										
KLHL14	57565	broad.mit.edu	37	chr18	30350174	30350174	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccgatggacgagcagccctgCagcaccaggttgttgatggc	14	12	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:30350174C>T	uc002kxm.1	-	2	769	c.381G>A	c.(379-381)CTG>CTA	p.L127L		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	127	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						AGCAGCCCTGCAGCACCAGGT	0.587													0	0	0	0.011902	0	38	118										T	30350174	C	T	30350174	2	4	80	1	0	0	0	0	0	0	0	1	8370	697	25	2		2	KLHL14	18	30350174	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	9123986	30350174	47727074	211	24099										
NEDD4L	23327	broad.mit.edu	37	chr18	56033354	56033354	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctagactgtggattgagtttGaatcagagaaaggtcttgac	12	5	2	5			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:56033354G>A	uc002lgy.2	+	21	2231	c.1957G>A	c.(1957-1959)GAA>AAA	p.E653K	NEDD4L_uc002lgz.2_Missense_Mutation_p.E589K|NEDD4L_uc002lgx.2_Missense_Mutation_p.E633K|NEDD4L_uc010xee.1_Missense_Mutation_p.E532K|NEDD4L_uc002lhc.2_Missense_Mutation_p.E645K|NEDD4L_uc002lhd.2_Missense_Mutation_p.E532K|NEDD4L_uc002lhb.2_Missense_Mutation_p.E512K|NEDD4L_uc002lhe.2_Missense_Mutation_p.E625K|NEDD4L_uc002lhf.2_Missense_Mutation_p.E512K|NEDD4L_uc002lhg.2_Missense_Mutation_p.E532K|NEDD4L_uc002lhh.2_Missense_Mutation_p.E428K|NEDD4L_uc010dpn.2_5'UTR	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	653	HECT.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GATTGAGTTTGAATCAGAGAA	0.418													0	0	0	0.013537	0	12	13										A	56033354	G	A	56033354	3	1	80	1	0	0	0	0	1	0	0	0	10311	1291	45	1	2067	1	NEDD4L	18	56033354	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	25683180	56033354	22043894	212	24100										
RTTN	25914	broad.mit.edu	37	chr18	67860668	67860668	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cttcatgacaataagacaaaGaagaattttgggaaactgtg	9	5	1	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:67860668G>A	uc002lkp.2	-	8	931	c.863C>T	c.(862-864)TCT>TTT	p.S288F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.S288F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	288							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				ATAAGACAAAGAAGAATTTTG	0.418													0	0	0	0.003163	0	14	42										A	67860668	G	A	67860668	3	1	80	1	0	0	0	0	1	0	0	0	13737	942	33	1	5985	1	RTTN	18	67860668	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	11827314	67860668	10216580	213	24101										
C19orf25	148223	broad.mit.edu	37	chr19	1475148	1475148	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cacctctgcctcagcacgttGcccgcctgctgcagccgctg	10	19	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:1475148G>T	uc002lsy.3	-	2	455	c.240C>A	c.(238-240)GGC>GGA	p.G80G	C19orf25_uc010xgn.1_Intron|C19orf25_uc010dsk.2_Silent_p.G80G|C19orf25_uc010xgo.1_Silent_p.G120G|C19orf25_uc002lsx.1_3'UTR	NM_152482	NP_689695	Q9UFG5	CS025_HUMAN	hypothetical protein LOC148223	80							protein binding				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGCACGTTGCCCGCCTGCT	0.672													1	0	0.00198382	0.001984	0.00201935	7	4										T	1475148	G	T	1475148	2	4	80	1	0	0	0	0	0	0	0	1	1915	1306	46	4		4	C19orf25	19	1475148	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		1475148	57653835	214	24102										
PTPRS	5802	broad.mit.edu	37	chr19	5258028	5258028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctggacgcggcgttccctacCtcgcacgtagaggttggcag	14	13	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:5258028C>T	uc002mbv.2	-	8	940	c.706G>A	c.(706-708)GAG>AAG	p.E236K	PTPRS_uc002mbu.1_Missense_Mutation_p.V227I|PTPRS_uc010xin.1_Missense_Mutation_p.V227I|PTPRS_uc002mbw.2_Missense_Mutation_p.V227I|PTPRS_uc002mbx.2_Missense_Mutation_p.E227K|PTPRS_uc002mby.2_Missense_Mutation_p.V227I	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	236	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CGTTCCCTACCTCGCACGTAG	0.662													0	0	0	0.010818	0	32	59										T	5258028	C	T	5258028	3	4	80	1	0	0	0	0	1	0	0	0	12811	695	24	2	5264	2	PTPRS	19	5258028	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	3782880	5258028	53870955	215	24103										
RPL36	25873	broad.mit.edu	37	chr19	5691448	5691448	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	caaggacaaacgggccctcaAatttatcaagaaaagggtag	10	8	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:5691448A>C	uc002mcv.2	+	3	281	c.212A>C	c.(211-213)AAA>ACA	p.K71T	RPL36_uc002mcw.2_Missense_Mutation_p.K71T	NM_033643	NP_378669	Q9Y3U8	RL36_HUMAN	ribosomal protein L36	71					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|structural constituent of ribosome				0						CGGGCCCTCAAATTTATCAAG	0.647											OREG0025183	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	26	67										C	5691448	A	C	5691448	3	2	80	1	0	0	0	0	1	0	0	0	13586	14	1	5	218	5	RPL36	19	5691448	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	433420	5691448	53437535	216	24104										
NRTN	4902	broad.mit.edu	37	chr19	5824219	5824219	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccttggcctcagtgctctgcAgctccgtgctgtccatctgg	11	15	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:5824219A>G	uc002mde.2	+	1	402	c.43A>G	c.(43-45)AGC>GGC	p.S15G		NM_004558	NP_004549	Q99748	NRTN_HUMAN	neurturin preproprotein	15					axon guidance|MAPKKK cascade|neural crest cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region	growth factor activity				0						AGTGCTCTGCAGCTCCGTGCT	0.697													0	0	0	0.001168	0	6	17										G	5824219	A	G	5824219	3	3	80	1	0	0	0	0	1	0	0	0	10664	188	7	5	45	5	NRTN	19	5824219	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	132771	5824219	53304764	217	24105										
MCOLN1	57192	broad.mit.edu	37	chr19	7592790	7592790	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acttccggctgaagaccattAacctccagagcctcatcaat	6	14	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:7592790A>G	uc002mgo.2	+	6	846	c.721A>G	c.(721-723)AAC>GAC	p.N241D	MCOLN1_uc002mgp.2_Missense_Mutation_p.N206D	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	241					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GAAGACCATTAACCTCCAGAG	0.612													0	0	0	0.003163	0	14	48										G	7592790	A	G	7592790	3	3	80	1	0	0	0	0	1	0	0	0	9395	362	13	5	743	5	MCOLN1	19	7592790	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	1768571	7592790	51536193	218	24106										
MUC16	94025	broad.mit.edu	37	chr19	9086960	9086960	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aatgtttgttgggccagtctCaatctctctggacagtgtgt	11	8	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:9086960C>G	uc002mkp.2	-	1	5059	c.4855G>C	c.(4855-4857)GAG>CAG	p.E1619Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1619	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGCCAGTCTCAATCTCTCTG	0.512													0	0	0	0.01441	0	57	117										G	9086960	C	G	9086960	3	3	80	1	0	0	0	0	1	0	0	0	9973	835	29	1	39004	1	MUC16	19	9086960	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1494170	9086960	50042023	219	24107										
STX10	8677	broad.mit.edu	37	chr19	13255242	13255242	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtcagagagagaatagtaaGatgagaacgaggagaagcac	15	4	1	5			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:13255242G>C	uc010xnb.1	-	8	732	c.732C>G	c.(730-732)ATC>ATG	p.I244M	STX10_uc002mwn.2_3'UTR|STX10_uc002mwo.2_3'UTR|STX10_uc010xna.1_RNA|STX10_uc010xnc.1_Missense_Mutation_p.I145M	NM_003765	NP_003756	O60499	STX10_HUMAN	syntaxin 10	244	Helical; Anchor for type IV membrane protein; (Potential).				Golgi vesicle transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane	SNAP receptor activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			AGAATAGTAAGATGAGAACGA	0.627													0	0	0	0.001984	0	7	10										C	13255242	G	C	13255242	3	2	80	1	0	0	0	0	1	0	0	0	15335	932	33	1	20	1	STX10	19	13255242	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	4168282	13255242	45873741	220	24108										
C19orf57	79173	broad.mit.edu	37	chr19	14000223	14000223	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gctatttctctgtgttccagCacaacagaggcttgcgggga	12	10	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:14000223C>G	uc002mxl.1	-	6	1505	c.1446G>C	c.(1444-1446)GTG>GTC	p.V482V	C19orf57_uc002mxk.1_Silent_p.V364V|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	482					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGTGTTCCAGCACAACAGAGG	0.622													0	0	0	0.003954	0	25	71										G	14000223	C	G	14000223	2	3	80	1	0	0	0	0	0	0	0	1	1939	697	25	4		4	C19orf57	19	14000223	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	744981	14000223	45128760	221	24109										
DPY19L3	147991	broad.mit.edu	37	chr19	32930033	32930033	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgcagaatagataccacaagAgttgagtttaccatcccact	7	10	0	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:32930033A>G	uc002ntg.2	+	7	788	c.612A>G	c.(610-612)AGA>AGG	p.R204R	DPY19L3_uc002nth.1_Silent_p.R204R|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	204						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					ATACCACAAGAGTTGAGTTTA	0.393													0	0	0	0.01441	0	55	91										G	32930033	A	G	32930033	2	3	80	1	0	0	0	0	0	0	0	1	4742	301	11	5		5	DPY19L3	19	32930033	Silent	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	18929810	32930033	26198950	222	24110										
CHST8	64377	broad.mit.edu	37	chr19	34180217	34180217	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggcctgcatgttctcttccaTcctgctgttcggagctgcag	11	13	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:34180217T>A	uc002nus.3	+	3	555	c.50T>A	c.(49-51)ATC>AAC	p.I17N	CHST8_uc002nut.3_Missense_Mutation_p.I17N|CHST8_uc002nuu.2_Missense_Mutation_p.I17N	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	17	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					TTCTCTTCCATCCTGCTGTTC	0.647													0	0	0	0.003954	0	27	134										A	34180217	T	A	34180217	3	1	80	1	0	0	0	0	1	0	0	0	3410	1435	50	5	52	5	CHST8	19	34180217	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	1250184	34180217	24948766	223	24111										
ZNF529	57711	broad.mit.edu	37	chr19	37045699	37045699	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tccctgagtgtcaccagttcCtgaaacaacaaacccgtaca	6	14	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:37045699C>A	uc002oeh.3	-	4	311	c.109_splice	c.e4-1	p.E37_splice	ZNF529_uc010xth.1_Splice_Site_p.E37_splice|ZNF529_uc010xti.1_Splice_Site_p.E19_splice|ZNF529_uc002oeg.3_Splice_Site	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					TCACCAGTTCCTGAAACAACA	0.413													1	0	0.000602214	0.000602	0.000622288	4	7										A	37045699	C	A	37045699	5	1	80	1	0	0	0	0	0	0	1	0	17967	695	24	4	1591	4	ZNF529	19	37045699	Splice_Site	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	2865482	37045699	22083284	224	24112										
RYR1	6261	broad.mit.edu	37	chr19	38939069	38939070	+	Missense_Mutation	DNP	TC	TC	AA													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	taccgggcagtacctagcgcTcaccgaggaccagggcctgg							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:38939069_38939070TC>AA	uc002oit.2	+	10	1005_1006	c.875_876TC>AA	c.(874-876)CTC>CAA	p.L292Q	RYR1_uc002oiu.2_Missense_Mutation_p.L292Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	292	MIR 4.|Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TACCTAGCGCTCACCGAGGACC	0.649													0	0	0	0.004672	0	20	271										AA	38939070	TC	AA	38939069	3	1	80	1	0	0	0	0	1	0	0	0	13768	1551	54	5	913	5	RYR1	19	38939069	Missense_Mutation	DNP	TC	TCGA-FD-A3SL-01A-21D-A22Z-08	1893370	38939069	20189914	225	24113										
PAK4	10298	broad.mit.edu	37	chr19	39660239	39660239	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tggagatctccgcgccgtccAacttcgagcaccgcgtgcac	11	16	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:39660239A>C	uc002okj.1	+	4	507	c.46A>C	c.(46-48)AAC>CAC	p.N16H	PAK4_uc002okl.1_Missense_Mutation_p.N16H|PAK4_uc002okn.1_Missense_Mutation_p.N16H|PAK4_uc002okm.1_Missense_Mutation_p.N16H|PAK4_uc002oko.1_Missense_Mutation_p.N16H|PAK4_uc002okp.1_Missense_Mutation_p.N16H	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	16	CRIB.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			CGCGCCGTCCAACTTCGAGCA	0.657													0	0	0	0.01441	0	52	91										C	39660239	A	C	39660239	3	2	80	1	0	0	0	0	1	0	0	0	11403	130	5	5	48	5	PAK4	19	39660239	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	721170	39660239	19468744	226	24114										
SPTBN4	57731	broad.mit.edu	37	chr19	41035036	41035036	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acttcctccgagactgccacGaggtaggaactccaggtgtg	12	12	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:41035036G>A	uc002ony.2	+	18	4032	c.3946G>A	c.(3946-3948)GAG>AAG	p.E1316K	SPTBN4_uc002onx.2_Missense_Mutation_p.E1316K|SPTBN4_uc002onz.2_Missense_Mutation_p.E1316K|SPTBN4_uc010egx.2_Missense_Mutation_p.E59K|SPTBN4_uc010egy.1_5'Flank|SPTBN4_uc002ooa.2_5'Flank|SPTBN4_uc010egz.1_5'Flank	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1316	Spectrin 11.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGACTGCCACGAGGTAGGAAC	0.597											OREG0025472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	19	72										A	41035036	G	A	41035036	3	1	80	1	0	0	0	0	1	0	0	0	15120	1059	37	1	4012	1	SPTBN4	19	41035036	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1374797	41035036	18093947	227	24115										
B3GNT8	374907	broad.mit.edu	37	chr19	41932181	41932181	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctggactgccccacgtctctCtcacggcctgtcgttctgca	9	17	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:41932181C>G	uc002oqs.2	-	3	957	c.503G>C	c.(502-504)AGA>ACA	p.R168T	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	168	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						CCACGTCTCTCTCACGGCCTG	0.627													0	0	0	0.01441	0	51	96										G	41932181	C	G	41932181	3	3	80	1	0	0	0	0	1	0	0	0	1263	913	32	1	694	1	B3GNT8	19	41932181	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	897145	41932181	17196802	228	24116										
MARK4	57787	broad.mit.edu	37	chr19	45767973	45767973	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaggtgattgagactgagaaGacgctgtacctggtgatgga	16	5	0	5			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:45767973G>A	uc002pbb.1	+	5	392	c.387G>A	c.(385-387)AAG>AAA	p.K129K	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.K129K|MARK4_uc002pbc.1_5'UTR			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	129	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGACTGAGAAGACGCTGTACC	0.577													0	0	0	0.01441	0	87	51										A	45767973	G	A	45767973	2	1	80	1	0	0	0	0	0	0	0	1	9315	933	33	1		1	MARK4	19	45767973	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3835792	45767973	13361010	229	24117										
PPP1R13L	10848	broad.mit.edu	37	chr19	45895489	45895489	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggctgcagcctcgtggggctGagaggccttgctacagggcc	17	12	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:45895489G>A	uc002pbn.2	-	8	1541	c.1464C>T	c.(1462-1464)CTC>CTT	p.L488L	PPP1R13L_uc002pbm.2_Silent_p.L67L|PPP1R13L_uc002pbo.2_Silent_p.L488L	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	488	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCGTGGGGCTGAGAGGCCTTG	0.672													0	0	0	0.007291	0	31	27										A	45895489	G	A	45895489	2	1	80	1	0	0	0	0	0	0	0	1	12358	1277	45	1		1	PPP1R13L	19	45895489	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	127516	45895489	13233494	230	24118										
LMTK3	114783	broad.mit.edu	37	chr19	49013790	49013790	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gaaggccagcaggccggagcAggaaatgaggaccacagcgt	16	10	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:49013790A>G	uc002pjk.2	-	3	223	c.223T>C	c.(223-225)TGC>CGC	p.C75R		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		AGGCCGGAGCAGGAAATGAGG	0.622													0	0	0	0.001984	0	6	3										G	49013790	A	G	49013790	3	3	80	1	0	0	0	0	1	0	0	0	8860	188	7	5	4302	5	LMTK3	19	49013790	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	3118301	49013790	10115193	231	24119										
ALDH16A1	126133	broad.mit.edu	37	chr19	49971709	49971709	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctggctgtggtgtgtccggaCgagtggcccctgcttgcctt	15	12	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:49971709C>T	uc002pnt.2	+	15	2126	c.2010C>T	c.(2008-2010)GAC>GAT	p.D670D	ALDH16A1_uc010yar.1_Silent_p.D619D|ALDH16A1_uc010yas.1_Silent_p.D505D|ALDH16A1_uc010yat.1_Silent_p.D507D	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	670							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TGTGTCCGGACGAGTGGCCCC	0.701													0	0	0	0.01441	0	114	79										T	49971709	C	T	49971709	2	4	80	1	0	0	0	0	0	0	0	1	488	535	19	2		2	ALDH16A1	19	49971709	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	957919	49971709	9157274	232	24120										
CACNG8	59283	broad.mit.edu	37	chr19	54483176	54483176	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agcgccatcctgctgctgctCgggggtgtgtgcgtggcggc	18	12	0	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:54483176C>G	uc002qcs.1	+	3	526	c.420C>G	c.(418-420)CTC>CTG	p.L140L	MIR935_hsa-mir-935|MI0005757_5'Flank	NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	141	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		TGCTGCTGCTCGGGGGTGTGT	0.637													0	0	0	0.007413	0	17	7										G	54483176	C	G	54483176	2	3	80	1	0	0	0	0	0	0	0	1	2563	871	31	1		1	CACNG8	19	54483176	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	4511467	54483176	4645807	233	24121										
BRSK1	84446	broad.mit.edu	37	chr19	55814746	55814746	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	agcggtatcccagctgtgagGaccaggacctgcctccccgg	13	15	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:55814746G>A	uc002qkg.2	+	11	1373	c.1096G>A	c.(1096-1098)GAC>AAC	p.D366N	BRSK1_uc002qkf.2_Missense_Mutation_p.D382N|BRSK1_uc002qkh.2_Missense_Mutation_p.D61N	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	366					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CAGCTGTGAGGACCAGGACCT	0.473													0	0	0	0.00278	0	23	94										A	55814746	G	A	55814746	3	1	80	1	0	0	0	0	1	0	0	0	1523	1174	41	1	1138	1	BRSK1	19	55814746	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1331570	55814746	3314237	234	24122										
PEG3	5178	broad.mit.edu	37	chr19	57335915	57335915	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctcagagtcagttggaccttCtcctatgatgacatccggct	9	12	3	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:57335915C>T	uc002qnu.2	-	1	460	c.109G>A	c.(109-111)GAA>AAA	p.E37K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E37K|PEG3_uc002qnv.2_Missense_Mutation_p.E37K|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.E37K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	37					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTTGGACCTTCTCCTATGATG	0.473													0	0	0	0.01441	0	72	41										T	57335915	C	T	57335915	3	4	80	1	0	0	0	0	1	0	0	0	11720	922	32	1		1	PEG3	19	57335915	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1521169	57335915	1793068	235	24123										
ADRA1D	146	broad.mit.edu	37	chr20	4228599	4228599	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acgggagaacttgagcaggcGcacggagagcgagctgcgga	18	9	0	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:4228599G>A	uc002wkr.2	-	1	1061	c.1006C>T	c.(1006-1008)CGC>TGC	p.R336C		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	336	Cytoplasmic (By similarity).				cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	TTGAGCAGGCGCACGGAGAGC	0.667													0	0	0	0.000602	0	5	14										A	4228599	G	A	4228599	3	1	80	1	0	0	0	0	1	0	0	0	336	1087	38	2	720	2	ADRA1D	20	4228599	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		4228599	58796921	236	24124										
SLC23A2	9962	broad.mit.edu	37	chr20	4854733	4854733	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	caggataccaggatggccagGatgatctggagtggtcaagg	16	7	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:4854733G>A	uc002wlg.1	-	11	1326	c.951C>T	c.(949-951)ATC>ATT	p.I317I	SLC23A2_uc010zqr.1_Silent_p.I202I|SLC23A2_uc002wlh.1_Silent_p.I317I|SLC23A2_uc002wli.2_Silent_p.I316I	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	317	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GGATGGCCAGGATGATCTGGA	0.552													0	0	0	0.007291	0	29	102										A	4854733	G	A	4854733	2	1	80	1	0	0	0	0	0	0	0	1	14463	1164	41	1		1	SLC23A2	20	4854733	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	626134	4854733	58170787	237	24125										
C20orf94	128710	broad.mit.edu	37	chr20	10541378	10541378	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tactgttaaaagaaaccattGattcaagagttcaggagtac	8	6	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:10541378G>C	uc010zre.1	+	4	328	c.148G>C	c.(148-150)GAT>CAT	p.D50H		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	50							protein binding				0						AGAAACCATTGATTCAAGAGT	0.323													0	0	0	0.013537	0	12	44										C	10541378	G	C	10541378	3	2	80	1	0	0	0	0	1	0	0	0	2121	1290	45	1	158	1	C20orf94	20	10541378	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	5686645	10541378	52484142	238	24126										
GGT7	2686	broad.mit.edu	37	chr20	33460480	33460480	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gtctcccagaaaggcgtcctCgtccttgcggcccctcagcg	11	17	2	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:33460480C>T	uc002xay.2	-	1	182	c.139G>A	c.(139-141)GAG>AAG	p.E47K	GGT7_uc002xaz.1_Missense_Mutation_p.E47K|GGT7_uc002xba.1_Missense_Mutation_p.E47K|ACSS2_uc002xbc.2_5'Flank	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	47	Cytoplasmic (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						AAGGCGTCCTCGTCCTTGCGG	0.697													0	0	0	0.004482	0	6	20										T	33460480	C	T	33460480	3	4	80	1	0	0	0	0	1	0	0	0	6364	893	31	1	1909	1	GGT7	20	33460480	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	22919102	33460480	29565040	239	24127										
PREX1	57580	broad.mit.edu	37	chr20	47248883	47248883	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	atgtcctgctgcaaatcctcCgcggcctggctgcctggaga	12	14	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:47248883C>G	uc002xtw.1	-	35	4481	c.4458G>C	c.(4456-4458)GCG>GCC	p.A1486A	PREX1_uc002xtv.1_Silent_p.A783A	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1486					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCAAATCCTCCGCGGCCTGGC	0.647													0	0	0	0.01441	0	49	131										G	47248883	C	G	47248883	2	3	80	1	0	0	0	0	0	0	0	1	12476	639	23	4		4	PREX1	20	47248883	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	13788403	47248883	15776637	240	24128										
SFRS15	57466	broad.mit.edu	37	chr21	33044500	33044500	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tggcggtgggcctctgtgcaTcatgtgcggtggcatgggac	18	9	2	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr21:33044500T>C	uc002ypd.2	-	20	3082	c.2656A>G	c.(2656-2658)ATG>GTG	p.M886V	SFRS15_uc002ype.2_Missense_Mutation_p.M864V|SFRS15_uc010glu.2_Missense_Mutation_p.M871V	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	886						nucleus	nucleotide binding|RNA binding				0						CCTCTGTGCATCATGTGCGGT	0.647													0	0	0	0.010729	0	11	60										C	33044500	T	C	33044500	3	2	80	1	0	0	0	0	1	0	0	0	14171	1435	50	5	791	5	SFRS15	21	33044500	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08		33044500	15085395	241	24129										
PCBP3	54039	broad.mit.edu	37	chr21	47330884	47330884	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acggagcgagcggtgaccatCtcggggaccccagatgccat	14	13	1	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr21:47330884C>T	uc002zhq.1	+	7	665	c.540C>T	c.(538-540)ATC>ATT	p.I180I	PCBP3_uc010gqb.2_Silent_p.I180I|PCBP3_uc002zhp.1_Silent_p.I180I|PCBP3_uc010gqc.1_Silent_p.I180I|PCBP3_uc002zhs.1_Silent_p.I180I|PCBP3_uc002zhr.1_Silent_p.I180I|PCBP3_uc002zht.1_Silent_p.I148I	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	180	KH 2.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CGGTGACCATCTCGGGGACCC	0.642													0	0	0	0.010504	0	19	23										T	47330884	C	T	47330884	2	4	80	1	0	0	0	0	0	0	0	1	11502	903	32	1		1	PCBP3	21	47330884	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	14286384	47330884	799011	242	24130										
C21orf58	54058	broad.mit.edu	37	chr21	47722421	47722421	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gcagggctgggggcagggccTtgagcatccagttctgcagg	18	10	1	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr21:47722421T>G	uc002zjf.2	-	8	1925	c.791A>C	c.(790-792)AAG>ACG	p.K264T	C21orf58_uc002ziz.2_Missense_Mutation_p.K181T|C21orf58_uc002zja.2_Missense_Mutation_p.K158T|C21orf58_uc011afw.1_Missense_Mutation_p.K181T|C21orf58_uc002zjc.2_Missense_Mutation_p.K158T|C21orf58_uc011afx.1_Missense_Mutation_p.K158T|C21orf58_uc010gqj.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	264										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		GGGCAGGGCCTTGAGCATCCA	0.582													0	0	0	0.006214	0	9	11										G	47722421	T	G	47722421	3	3	80	1	0	0	0	0	1	0	0	0	2129	1609	56	5	185	5	C21orf58	21	47722421	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	391537	47722421	407474	243	24131										
COMT	1312	broad.mit.edu	37	chr22	19951251	19951251	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ctgtgccgccatcacccagcGgatggtggatttcgctggcg	14	13	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr22:19951251G>C	uc002zqu.2	+	4	701	c.452G>C	c.(451-453)CGG>CCG	p.R151P	COMT_uc002zqt.2_Missense_Mutation_p.R151P|COMT_uc002zqv.2_Missense_Mutation_p.R151P|COMT_uc002zqw.2_Missense_Mutation_p.R151P|COMT_uc011ahd.1_Missense_Mutation_p.R151P|COMT_uc002zqx.2_Missense_Mutation_p.R151P	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	151					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	ATCACCCAGCGGATGGTGGAT	0.627													0	0	0	0.00278	0	22	19										C	19951251	G	C	19951251	3	2	80	1	0	0	0	0	1	0	0	0	3725	1116	39	4	458	4	COMT	22	19951251	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		19951251	31353315	244	24132										
THOC5	8563	broad.mit.edu	37	chr22	29925227	29925227	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	attgccacagataacgtcttAtctggggggcaagaagaagt	12	7	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr22:29925227A>T	uc003afr.2	-	10	1184	c.849T>A	c.(847-849)GAT>GAA	p.D283E	THOC5_uc003afq.2_5'Flank|THOC5_uc003afs.2_Missense_Mutation_p.D283E|THOC5_uc003aft.2_Missense_Mutation_p.D283E|THOC5_uc003afu.2_Missense_Mutation_p.D283E|THOC5_uc010gvo.2_Missense_Mutation_p.N27K|THOC5_uc003afv.1_Missense_Mutation_p.D294E	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	283					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ATAACGTCTTATCTGGGGGGC	0.532													0	0	0	0.01441	0	55	90										T	29925227	A	T	29925227	3	4	80	1	0	0	0	0	1	0	0	0	15865	463	16	5	1250	5	THOC5	22	29925227	Missense_Mutation	SNP	A	TCGA-FD-A3SL-01A-21D-A22Z-08	9973976	29925227	21379339	245	24133										
MXRA5	25878	broad.mit.edu	37	chrX	3241401	3241401	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cgctccggattaatctgtttGtttgccatgtttatccttcg	8	10	1	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:3241401G>C	uc004crg.3	-	5	2482	c.2325C>G	c.(2323-2325)AAC>AAG	p.N775K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	775						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TAATCTGTTTGTTTGCCATGT	0.443													0	0	0	0.01441	0	46	30										C	3241401	G	C	3241401	3	2	80	1	0	0	0	0	1	0	0	0	10003	1368	48	4	6173	4	MXRA5	23	3241401	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08		3241401	152029159	246	24134										
KLHL15	80311	broad.mit.edu	37	chrX	24024257	24024257	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acctgctcagatgatcattaTccaagtaagacatgagcttc	7	10	2	4			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:24024257T>C	uc004dba.3	-	3	810	c.554A>G	c.(553-555)GAT>GGT	p.D185G		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	185	BACK.									ovary(1)|breast(1)	2						ATGATCATTATCCAAGTAAGA	0.478													0	0	0	0.001168	0	5	96										C	24024257	T	C	24024257	3	2	80	1	0	0	0	0	1	0	0	0	8371	1435	50	5	1268	5	KLHL15	23	24024257	Missense_Mutation	SNP	T	TCGA-FD-A3SL-01A-21D-A22Z-08	20782856	24024257	131246303	247	24135										
TSPYL2	64061	broad.mit.edu	37	chrX	53111922	53111923	+	Frame_Shift_Ins	INS	-	-	G													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ccctatgtcattctcgaggaINSgggggggatccgcgcatact							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:53111922_53111923insG	uc004drw.2	+	1	374_375	c.242_243insG	c.(241-243)GAGfs	p.E81fs	TSPYL2_uc004drv.2_Frame_Shift_Ins_p.E81fs|TSPYL2_uc004drx.1_5'Flank	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	81					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0						ATTCTCGAGGAGGGGGGGATCC	0.693																		5	4	---	---								G	53111923	-	G	53111922	7	5	80	1	0	1	1	0	0	0	0	0	16657	304	11	0	244	0	TSPYL2	23	53111922	Frame_Shift_Ins	INS	-	TCGA-FD-A3SL-01A-21D-A22Z-08	29087665	53111922	102158638	248	24136										
MED12	9968	broad.mit.edu	37	chrX	70339253	70339258	+	In_Frame_Del	DEL	GGTTTC	GGTTTC	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	cggccttgaatgtaaaacaaGgtttcaataaccagcctgct							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:70339253_70339258delGGTTTC	uc004dyy.2	+	2	329_334	c.130_135delGGTTTC	c.(130-135)GGTTTCdel	p.GF44del	MED12_uc011mpq.1_In_Frame_Del_p.GF44del|MED12_uc004dyz.2_In_Frame_Del_p.GF44del|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	44_45					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGTAAAACAAGGTTTCAATAACCAGC	0.413																		5	3	---	---								-	70339258	GGTTTC	-	70339253	7	5	80	1	0	1	0	1	0	0	0	0	9428	1000	35	0	136	0	MED12	23	70339253	In_Frame_Del	DEL	GGTTTC	TCGA-FD-A3SL-01A-21D-A22Z-08	17227331	70339253	84931307	249	24137										
KIAA2022	340533	broad.mit.edu	37	chrX	73961258	73961258	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggtcagtggactcctttagtGgtgctatctcatcaatgctt	10	9	3	0			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:73961258G>C	uc004eby.2	-	3	3751	c.3134C>G	c.(3133-3135)CCA>CGA	p.P1045R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1045					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTCCTTTAGTGGTGCTATCTC	0.502													0	0	0	0.004289	0	38	21										C	73961258	G	C	73961258	3	2	80	1	0	0	0	0	1	0	0	0	8269	1348	47	4	1424	4	KIAA2022	23	73961258	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	3622005	73961258	81309302	250	24138										
MAGEE1	57692	broad.mit.edu	37	chrX	75649899	75649899	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	aatatattgttaaagaatatCgcaaccagtttcctgagata	6	6	0	2			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:75649899C>T	uc004ecm.1	+	1	1783	c.1576C>T	c.(1576-1578)CGC>TGC	p.R526C		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	526	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						TAAAGAATATCGCAACCAGTT	0.478													0	0	0	0.00278	0	22	5										T	75649899	C	T	75649899	3	4	80	1	0	0	0	0	1	0	0	0	9185	884	31	1	1578	1	MAGEE1	23	75649899	Missense_Mutation	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	1688641	75649899	79620661	251	24139										
TMEM164	84187	broad.mit.edu	37	chrX	109416577	109416577	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	ggacaccagactctcatgacCatgacccacgggaagctggt	11	13	1	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:109416577C>A	uc004eom.2	+	7	1111	c.792C>A	c.(790-792)ACC>ACA	p.T264T	TMEM164_uc004eol.2_Silent_p.T115T|TMEM164_uc010npq.2_Silent_p.T225T|TMEM164_uc004eon.1_5'Flank	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	264	Helical; (Potential).					integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						CTCTCATGACCATGACCCACG	0.532													1	0	6.68952e-21	0.013114	7.5534e-21	44	29										A	109416577	C	A	109416577	2	1	80	1	0	0	0	0	0	0	0	1	16076	581	21	4		4	TMEM164	23	109416577	Silent	SNP	C	TCGA-FD-A3SL-01A-21D-A22Z-08	33766678	109416577	45853983	252	24140										
XIAP	331	broad.mit.edu	37	chrX	123040977	123040977	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	tgtgctgaagcagttgacaaGtgtcccatgtgctacacagt	11	9	0	2	rs61757634		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:123040977G>A	uc010nqu.2	+	7	1566	c.1440G>A	c.(1438-1440)AAG>AAA	p.K480K	XIAP_uc004etx.2_Silent_p.K480K|XIAP_uc010nqv.2_Silent_p.K106K	NM_001167	NP_001158	P98170	XIAP_HUMAN	baculoviral IAP repeat-containing protein 4	480	RING-type.				anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			ovary(1)|lung(1)	2						CAGTTGACAAGTGTCCCATGT	0.343									X-linked_Lymphoproliferative_syndrome				0	0	0	0.00623	0	41	22										A	123040977	G	A	123040977	2	1	80	1	0	0	0	0	0	0	0	1	17425	1020	36	2		2	XIAP	23	123040977	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	13624400	123040977	32229583	253	24141										
STAG2	10735	broad.mit.edu	37	chrX	123179177	123179178	+	Frame_Shift_Del	DEL	AC	AC	-													0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	acttcttacaggattgtctgActcacaagtcagagcatttc							TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			AC	-	AC	AC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:123179177_123179178delAC	uc004etz.3	+	7	965_966	c.626_627delAC	c.(625-627)GACfs	p.D209fs	STAG2_uc004eua.2_Frame_Shift_Del_p.D209fs|STAG2_uc004eub.2_Frame_Shift_Del_p.D209fs|STAG2_uc004euc.2_Frame_Shift_Del_p.D209fs|STAG2_uc004eud.2_Frame_Shift_Del_p.D209fs|STAG2_uc004eue.2_Frame_Shift_Del_p.D209fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	209					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GGATTGTCTGACTCACAAGTCA	0.361																		111	65	---	---								-	123179178	AC	-	123179177	7	5	80	1	0	1	0	1	0	0	0	0	15242	275	10	0	648	0	STAG2	23	123179177	Frame_Shift_Del	DEL	AC	TCGA-FD-A3SL-01A-21D-A22Z-08	138200	123179177	32091383	254	24142										
MAGEC2	51438	broad.mit.edu	37	chrX	141290659	141290659	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	actatcctagacttcactcaGaaaaggagacgttgctggac	9	10	2	3			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:141290659G>A	uc004fbu.1	-	3	1463	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	372						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACTTCACTCAGAAAAGGAGAC	0.512										HNSCC(46;0.14)			0	0	0	0.007835	0	40	22										A	141290659	G	A	141290659	3	1	80	1	0	0	0	0	1	0	0	0	9181	942	33	1	10	1	MAGEC2	23	141290659	Missense_Mutation	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	18111482	141290659	13979901	255	24143										
SLITRK4	139065	broad.mit.edu	37	chrX	142718330	142718330	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.1875	48	8.51863517688465e-08	2.22991157247213	2.63678051865908	1.95270415858651	0.844193503713087	0.930043690531367	26	gacacggccaatgtgttccaGaaccccgatataagggagct	11	11	0	1			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:142718330G>A	uc004fbx.2	-	2	971	c.595C>T	c.(595-597)CTG>TTG	p.L199L	SLITRK4_uc004fby.2_Silent_p.L199L	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	199	Extracellular (Potential).|LRR 6.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATGTGTTCCAGAACCCCGATA	0.443													0	0	0	0.01441	0	48	35										A	142718330	G	A	142718330	2	1	80	1	0	0	0	0	0	0	0	1	14745	933	33	1		1	SLITRK4	23	142718330	Silent	SNP	G	TCGA-FD-A3SL-01A-21D-A22Z-08	1427671	142718330	12552230	256	24144										
SAMD11	148398	broad.mit.edu	37	chr1	865617	865617	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggagcgaactcccagcttctCtgccagcgatggtgacagcg	13	13	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:865617C>G	uc001abw.1	+	3	235	c.155C>G	c.(154-156)TCT>TGT	p.S52C	SAMD11_uc001abv.1_Missense_Mutation_p.S52C	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	52						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCCAGCTTCTCTGCCAGCGAT	0.597													0	0	0	0.001984	0	6	20										G	865617	C	G	865617	3	3	81	1	0	0	0	0	1	0	0	0	13816	913	32	1	161	1	SAMD11	1	865617	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		865617	248385004	1	24145										
TAS1R1	80835	broad.mit.edu	37	chr1	6639125	6639125	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tccaccaaggtacctacattCtaccacgcctgggtccaaaa	6	15	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:6639125C>G	uc001ant.2	+	6	2007	c.2007C>G	c.(2005-2007)TTC>TTG	p.F669L	TAS1R1_uc001anu.2_Missense_Mutation_p.F415L|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	669	Cytoplasmic (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TACCTACATTCTACCACGCCT	0.522													0	0	0	0.009718	0	37	83										G	6639125	C	G	6639125	3	3	81	1	0	0	0	0	1	0	0	0	15559	912	32	1	2029	1	TAS1R1	1	6639125	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	5773508	6639125	242611496	2	24146										
TAS1R1	80835	broad.mit.edu	37	chr1	6639332	6639332	+	Silent	SNP	C	C	T													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttcctctacaatggcctcctCtccatcagtgcctttgcctg							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:6639332C>T	uc001ant.2	+	6	2214	c.2214C>T	c.(2212-2214)CTC>CTT	p.L738L	TAS1R1_uc001anu.2_Silent_p.L484L|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	738	Helical; Name=5; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		ATGGCCTCCTCTCCATCAGTG	0.542													0	0	0	0.006122	0	18	48										T	6639332	C	T	6639332	2	4	81	1	0	0	0	0	0	0	0	1	15559	900	32	1		1	TAS1R1	1	6639332	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	207	6639332	242611289	3	24147	121	2								
TAS1R1	80835	broad.mit.edu	37	chr1	6639338	6639338	+	Silent	SNP	C	C	T													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tacaatggcctcctctccatCagtgcctttgcctgcagcta							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:6639338C>T	uc001ant.2	+	6	2220	c.2220C>T	c.(2218-2220)ATC>ATT	p.I740I	TAS1R1_uc001anu.2_Silent_p.I486I|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	740	Helical; Name=5; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TCCTCTCCATCAGTGCCTTTG	0.547													0	0	0	0.00499	0	18	52										T	6639338	C	T	6639338	2	4	81	1	0	0	0	0	0	0	0	1	15559	816	29	1		1	TAS1R1	1	6639338	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	6	6639338	242611283	4	24148	121	2								
PTCHD2	57540	broad.mit.edu	37	chr1	11561856	11561856	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtgagtgccaacactcagacGcacgcgcactggcgcatcga	12	14	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:11561856G>A	uc001ash.3	+	2	945	c.807G>A	c.(805-807)ACG>ACA	p.T269T	PTCHD2_uc001asi.1_Silent_p.T269T	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	269	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		ACACTCAGACGCACGCGCACT	0.677													0	0	0	0.001368	0	12	20										A	11561856	G	A	11561856	2	1	81	1	0	0	0	0	0	0	0	1	12733	1074	38	2		2	PTCHD2	1	11561856	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	4922518	11561856	237688765	5	24149										
IL22RA1	58985	broad.mit.edu	37	chr1	24463780	24463780	+	Frame_Shift_Del	DEL	C	C	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctgacagcccttctttgccaCccagtccctctctccgtacc							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:24463780delC	uc001biq.1	-	3	235	c.196delG	c.(196-198)GTGfs	p.V66fs	IL22RA1_uc010oeg.1_5'UTR|IL22RA1_uc009vrb.1_5'UTR|IL22RA1_uc010oeh.1_Frame_Shift_Del_p.V66fs	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	66	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		TTCTTTGCCACCCAGTCCCTC	0.587																		22	75	---	---								-	24463780	C	-	24463780	7	5	81	1	0	1	0	1	0	0	0	0	7673	507	18	0	1548	0	IL22RA1	1	24463780	Frame_Shift_Del	DEL	C	TCGA-FD-A3SM-01A-11D-A22Z-08	12901924	24463780	224786841	6	24150										
LHX8	431707	broad.mit.edu	37	chr1	75609605	75609605	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aaaaccagcaaaaagagctcGgaccagctttacagcagatc	8	11	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:75609605G>A	uc001dgo.2	+	7	1350	c.686G>A	c.(685-687)CGG>CAG	p.R229Q	LHX8_uc001dgq.2_Missense_Mutation_p.R168Q	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	229	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAAAGAGCTCGGACCAGCTTT	0.403													0	0	0	0.001855	0	14	37										A	75609605	G	A	75609605	3	1	81	1	0	0	0	0	1	0	0	0	8776	1116	39	2	708	2	LHX8	1	75609605	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	51145825	75609605	173641016	7	24151										
ODF2L	57489	broad.mit.edu	37	chr1	86842058	86842058	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctatagcctcattcttattcAttcttgattgcaggttccac	5	11	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:86842058A>G	uc001dll.1	-	8	1008	c.668T>C	c.(667-669)ATG>ACG	p.M223T	ODF2L_uc001dlm.1_Missense_Mutation_p.M223T|ODF2L_uc001dln.2_Missense_Mutation_p.M223T|ODF2L_uc001dlo.2_Missense_Mutation_p.M92T|ODF2L_uc001dlp.2_Missense_Mutation_p.M223T|ODF2L_uc010osg.1_Missense_Mutation_p.M223T|ODF2L_uc001dlq.1_Missense_Mutation_p.M53T|ODF2L_uc009wcr.1_Missense_Mutation_p.M92T	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	223						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		ATTCTTATTCATTCTTGATTG	0.313													0	0	0	0.001368	0	11	25										G	86842058	A	G	86842058	3	3	81	1	0	0	0	0	1	0	0	0	10828	217	8	5	1462	5	ODF2L	1	86842058	Missense_Mutation	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	11232453	86842058	162408563	8	24152										
KIAA1324	57535	broad.mit.edu	37	chr1	109732234	109732234	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctgggaggtggctggtgatCacatttacacagctgctgga	15	8	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:109732234C>T	uc001dwq.2	+	12	1505	c.1369C>T	c.(1369-1371)CAC>TAC	p.H457Y	KIAA1324_uc009wex.1_Missense_Mutation_p.H407Y|KIAA1324_uc009wey.2_Missense_Mutation_p.H370Y|KIAA1324_uc010ovg.1_Missense_Mutation_p.H355Y|KIAA1324_uc001dwr.2_Missense_Mutation_p.H107Y	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	457	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GGCTGGTGATCACATTTACAC	0.517													0	0	0	0.00499	0	15	21										T	109732234	C	T	109732234	3	4	81	1	0	0	0	0	1	0	0	0	8223	826	29	1	1411	1	KIAA1324	1	109732234	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	22890176	109732234	139518387	9	24153										
DDX20	11218	broad.mit.edu	37	chr1	112308378	112308378	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gatcccattccttctggtctGatggaagaatgtgtggattg	12	7	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:112308378G>C	uc001ebs.2	+	11	1689	c.1332G>C	c.(1330-1332)CTG>CTC	p.L444L	DDX20_uc010owf.1_Silent_p.L206L|DDX20_uc001ebt.2_Silent_p.L52L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	444	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCTGGTCTGATGGAAGAAT	0.353													0	0	0	0.004878	0	38	74										C	112308378	G	C	112308378	2	2	81	1	0	0	0	0	0	0	0	1	4348	1277	45	1		1	DDX20	1	112308378	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2576144	112308378	136942243	10	24154										
BCL9	607	broad.mit.edu	37	chr1	147090999	147090999	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gagccccccacactgggagaGaatcccgatggcctatctca	10	15	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:147090999G>C	uc001epq.2	+	8	1778	c.1038G>C	c.(1036-1038)GAG>GAC	p.E346D	BCL9_uc010ozr.1_Missense_Mutation_p.E272D	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	346	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CACTGGGAGAGAATCCCGATG	0.577			T	IGH@|IGL@	B-ALL								0	0	0	0.00361	0	74	167										C	147090999	G	C	147090999	3	2	81	1	0	0	0	0	1	0	0	0	1381	933	33	1	1056	1	BCL9	1	147090999	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	34782621	147090999	102159622	11	24155										
HAX1	10456	broad.mit.edu	37	chr1	154245817	154245817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgcctccactctcagccacaGagatcccttttttggaggga	9	13	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:154245817G>A	uc001fes.2	+	2	220	c.59G>A	c.(58-60)AGA>AAA	p.R20K	HAX1_uc001fet.2_Intron|HAX1_uc010peo.1_Missense_Mutation_p.R20K|HAX1_uc009wou.2_5'UTR|HAX1_uc009wov.2_5'UTR	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	20	Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCAGCCACAGAGATCCCTTT	0.493									Kostmann_syndrome				0	0	0	0.009535	0	31	114										A	154245817	G	A	154245817	3	1	81	1	0	0	0	0	1	0	0	0	6975	942	33	1	65	1	HAX1	1	154245817	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	7154818	154245817	95004804	12	24156										
C1orf114	57821	broad.mit.edu	37	chr1	169390861	169390861	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatctttgctgtagaatcttCtttcttggtgccactgacag	8	9	4	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:169390861C>G	uc001gga.1	-	3	976	c.808G>C	c.(808-810)GAA>CAA	p.E270Q	C1orf114_uc001gfz.1_Missense_Mutation_p.E270Q|C1orf114_uc009wvq.1_Missense_Mutation_p.E270Q|C1orf114_uc001ggb.2_Missense_Mutation_p.E270Q|C1orf114_uc001ggc.1_Missense_Mutation_p.E270Q	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	270											0	all_hematologic(923;0.208)					GTAGAATCTTCTTTCTTGGTG	0.468													0	0	0	0.00361	0	50	170										G	169390861	C	G	169390861	3	3	81	1	0	0	0	0	1	0	0	0	1987	922	32	1	734	1	C1orf114	1	169390861	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	15145044	169390861	79859760	13	24157										
METTL13	51603	broad.mit.edu	37	chr1	171753057	171753057	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acatgacgcagatggagtttCctgatgcctcgttccaggtg	12	10	0	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:171753057C>T	uc001ghz.2	+	2	678	c.331C>T	c.(331-333)CCT>TCT	p.P111S	METTL13_uc001gia.2_Missense_Mutation_p.P25S|METTL13_uc001gib.2_Missense_Mutation_p.P111S|METTL13_uc010pml.1_Missense_Mutation_p.P110S	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	111							methyltransferase activity|protein binding			kidney(1)	1						GATGGAGTTTCCTGATGCCTC	0.527													0	0	0	0.008871	0	21	75										T	171753057	C	T	171753057	3	4	81	1	0	0	0	0	1	0	0	0	9497	855	30	1	337	1	METTL13	1	171753057	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2362196	171753057	77497564	14	24158										
RC3H1	149041	broad.mit.edu	37	chr1	173930937	173930937	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctcgatctgttggtatctttCtctggattctggtacatacg	9	9	4	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:173930937C>G	uc001gju.3	-	11	2215	c.2128G>C	c.(2128-2130)GAA>CAA	p.E710Q	RC3H1_uc010pms.1_Missense_Mutation_p.E710Q|RC3H1_uc001gjv.2_Missense_Mutation_p.E710Q|RC3H1_uc010pmt.1_Missense_Mutation_p.E710Q	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	710	Pro-rich.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGGTATCTTTCTCTGGATTCT	0.438													0	0	0	0.00361	0	59	196										G	173930937	C	G	173930937	3	3	81	1	0	0	0	0	1	0	0	0	13166	922	32	1	1309	1	RC3H1	1	173930937	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2177880	173930937	75319684	15	24159										
LAMC1	3915	broad.mit.edu	37	chr1	183096408	183096408	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttcacttcagtgcaaagatGatggtcgctgtgaatgcaga	11	7	2	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:183096408G>A	uc001gpy.3	+	17	3249	c.2992G>A	c.(2992-2994)GAT>AAT	p.D998N		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	998	Laminin EGF-like 11.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGCAAAGATGATGGTCGCTG	0.433													0	0	0	0.00499	0	18	54										A	183096408	G	A	183096408	3	1	81	1	0	0	0	0	1	0	0	0	8614	1290	45	1	3058	1	LAMC1	1	183096408	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	9165471	183096408	66154213	16	24160										
C1orf26	54823	broad.mit.edu	37	chr1	185130013	185130013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtgggaaaaaagagacatctCagaggaaagacaccaccacc	10	10	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:185130013C>G	uc001grg.3	+	2	154	c.40C>G	c.(40-42)CAG>GAG	p.Q14E	C1orf26_uc001grh.3_Missense_Mutation_p.Q14E	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	14											0						AGAGACATCTCAGAGGAAAGA	0.323													0	0	0	0.008871	0	15	51										G	185130013	C	G	185130013	3	3	81	1	0	0	0	0	1	0	0	0	2035	827	29	1	42	1	C1orf26	1	185130013	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2033605	185130013	64120608	17	24161										
CHIT1	1118	broad.mit.edu	37	chr1	203192777	203192777	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggttgttggccgtggctaccAtatctgtgaacctgtgaggt	14	8	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:203192777A>T	uc001gzn.2	-	5	422	c.326T>A	c.(325-327)ATG>AAG	p.M109K	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.M100K	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	109					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						CGTGGCTACCATATCTGTGAA	0.542													0	0	0	0.00361	0	51	180										T	203192777	A	T	203192777	3	4	81	1	0	0	0	0	1	0	0	0	3346	217	8	5	1102	5	CHIT1	1	203192777	Missense_Mutation	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	18062764	203192777	46057844	18	24162										
REN	5972	broad.mit.edu	37	chr1	204125342	204125342	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttggctcccaaggcctccatGagcttctctatggagctggt	11	12	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:204125342G>A	uc001haq.2	-	8	968	c.924C>T	c.(922-924)CTC>CTT	p.L308L		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	308					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGGCCTCCATGAGCTTCTCTA	0.562													0	0	0	0.00361	0	100	357										A	204125342	G	A	204125342	2	1	81	1	0	0	0	0	0	0	0	1	13224	1277	45	1		1	REN	1	204125342	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	932565	204125342	45125279	19	24163										
DISP1	84976	broad.mit.edu	37	chr1	223116319	223116319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	caacaagaacaaaagtgagtCcaaatggatgcctgcaactt	8	9	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:223116319C>T	uc001hnu.1	+	2	301	c.154C>T	c.(154-156)CCA>TCA	p.P52S		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	52					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AAAAGTGAGTCCAAATGGATG	0.512													0	0	0	0.001882	0	22	78										T	223116319	C	T	223116319	3	4	81	1	0	0	0	0	1	0	0	0	4539	855	30	1	156	1	DISP1	1	223116319	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	18990977	223116319	26134302	20	24164										
C1orf35	79169	broad.mit.edu	37	chr1	228288840	228288840	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agggtccagccatcaggcctCagagcctctgtcatgccacc	10	16	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:228288840C>T	uc001hrx.2	-	8	878	c.784G>A	c.(784-786)GAG>AAG	p.E262K	C1orf35_uc009xew.2_RNA	NM_024319	NP_077295	Q9BU76	MMTA2_HUMAN	hypothetical protein LOC79169	262				E -> K (in Ref. 1; AAN15215).							0		Prostate(94;0.0488)				CATCAGGCCTCAGAGCCTCTG	0.627													0	0	0	0.002522	0	44	108										T	228288840	C	T	228288840	3	4	81	1	0	0	0	0	1	0	0	0	2038	835	29	1	11	1	C1orf35	1	228288840	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	5172521	228288840	20961781	21	24165										
OBSCN	84033	broad.mit.edu	37	chr1	228556048	228556048	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cccttgccgcaggtcaaggtCtacatccagcagctggtgga	12	13	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:228556048C>T	uc009xez.1	+	88	19742	c.19698C>T	c.(19696-19698)GTC>GTT	p.V6566V	OBSCN_uc001hsr.1_Silent_p.V1195V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6566	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGGTCAAGGTCTACATCCAGC	0.622													0	0	0	0.009096	0	4	9										T	228556048	C	T	228556048	2	4	81	1	0	0	0	0	0	0	0	1	10812	900	32	1		1	OBSCN	1	228556048	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	267208	228556048	20694573	22	24166										
EXOC8	149371	broad.mit.edu	37	chr1	231473425	231473425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cttcacgtacagccgcgcctCaaaaccccctgactccagct	6	19	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:231473425C>G	uc001huq.2	-	1	154	c.67G>C	c.(67-69)GAG>CAG	p.E23Q	C1orf124_uc001hur.2_5'Flank|C1orf124_uc001hus.2_5'Flank|C1orf124_uc001hut.2_5'Flank	NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	23					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGCCGCGCCTCAAAACCCCCT	0.667													0	0	0	0.004878	0	35	109										G	231473425	C	G	231473425	3	3	81	1	0	0	0	0	1	0	0	0	5311	835	29	1	2114	1	EXOC8	1	231473425	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2917377	231473425	17777196	23	24167										
DDX1	1653	broad.mit.edu	37	chr2	15753407	15753407	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctctctgttttggaaaatgGagtaagttgtagttttaatt	10	3	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:15753407G>C	uc002rce.2	+	14	1304	c.1016G>C	c.(1015-1017)GGA>GCA	p.G339A	DDX1_uc010yjq.1_Missense_Mutation_p.G247A	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	339	Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		TTGGAAAATGGAGTAAGTTGT	0.323													0	0	0	0.004482	0	8	28										C	15753407	G	C	15753407	3	2	81	1	0	0	0	0	1	0	0	0	4341	1188	41	1	1070	1	DDX1	2	15753407	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		15753407	227445966	24	24168										
ITSN2	50618	broad.mit.edu	37	chr2	24522785	24522785	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acttaaaaataacctctcgtCtttctatgtcttttctcctt	2	11	5	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24522785C>G	uc002rfe.2	-	12	1595	c.1337G>C	c.(1336-1338)AGA>ACA	p.R446T	ITSN2_uc002rff.2_Missense_Mutation_p.R446T|ITSN2_uc002rfg.2_Missense_Mutation_p.R446T|ITSN2_uc010eyd.2_Missense_Mutation_p.R471T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	446	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACCTCTCGTCTTTCTATGTC	0.289													0	0	0	0.003163	0	14	60										G	24522785	C	G	24522785	3	3	81	1	0	0	0	0	1	0	0	0	7927	913	32	1	3923	1	ITSN2	2	24522785	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8769378	24522785	218676588	25	24169			1	107		4	3	248	N	C	1.778461e-06
ITSN2	50618	broad.mit.edu	37	chr2	24522905	24522905	+	Missense_Mutation	SNP	C	C	T													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cttgtaattctctctgttttCgttcccactcttccttttct							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24522905C>T	uc002rfe.2	-	12	1475	c.1217G>A	c.(1216-1218)CGA>CAA	p.R406Q	ITSN2_uc002rff.2_Missense_Mutation_p.R406Q|ITSN2_uc002rfg.2_Missense_Mutation_p.R406Q|ITSN2_uc010eyd.2_Missense_Mutation_p.R431Q	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	406	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCTGTTTTCGTTCCCACTC	0.453													0	0	0	0.002445	0	30	114										T	24522905	C	T	24522905	3	4	81	1	0	0	0	0	1	0	0	0	7927	884	31	1	4043	1	ITSN2	2	24522905	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	120	24522905	218676468	26	24170	122	2	1	107		4	3	248	N	C	1.778461e-06
ITSN2	50618	broad.mit.edu	37	chr2	24522915	24522915	+	Missense_Mutation	SNP	C	C	T													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tctctgttttcgttcccactCttccttttctttctgggctt							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24522915C>T	uc002rfe.2	-	12	1465	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	ITSN2_uc002rff.2_Missense_Mutation_p.E403K|ITSN2_uc002rfg.2_Missense_Mutation_p.E403K|ITSN2_uc010eyd.2_Missense_Mutation_p.E428K	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	403	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTCCCACTCTTCCTTTTCT	0.453													0	0	0	0.004878	0	32	118										T	24522915	C	T	24522915	3	4	81	1	0	0	0	0	1	0	0	0	7927	922	32	1	4053	1	ITSN2	2	24522915	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	10	24522915	218676458	27	24171	122	2	1	107		4	3	248	N	C	1.778461e-06
ITSN2	50618	broad.mit.edu	37	chr2	24523032	24523032	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gttggctttccgtttgtcctCaaaagtaactgaacaaggta	9	8	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24523032C>G	uc002rfe.2	-	12	1348	c.1090G>C	c.(1090-1092)GAG>CAG	p.E364Q	ITSN2_uc002rff.2_Missense_Mutation_p.E364Q|ITSN2_uc002rfg.2_Missense_Mutation_p.E364Q|ITSN2_uc010eyd.2_Missense_Mutation_p.E389Q	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	364	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTTGTCCTCAAAAGTAACT	0.448													0	0	0	0.00874	0	39	55										G	24523032	C	G	24523032	3	3	81	1	0	0	0	0	1	0	0	0	7927	835	29	1	4170	1	ITSN2	2	24523032	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	117	24523032	218676341	28	24172			1	107		4	3	248	N	C	1.778461e-06
NCOA1	8648	broad.mit.edu	37	chr2	24930608	24930608	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctatcttttagataaagatGagaaagatttaagatcaact	7	4	2	5			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24930608G>T	uc002rfk.2	+	11	2527	c.2269G>T	c.(2269-2271)GAG>TAG	p.E757*	NCOA1_uc010eye.2_Nonsense_Mutation_p.E757*|NCOA1_uc002rfi.2_Nonsense_Mutation_p.E606*|NCOA1_uc002rfj.2_Nonsense_Mutation_p.E757*|NCOA1_uc002rfl.2_Nonsense_Mutation_p.E757*	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	757									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGATAAAGATGAGAAAGATTT	0.378			T	PAX3	alveolar rhadomyosarcoma								1	0	6.42651e-13	0.000978	6.70392e-13	12	25										T	24930608	G	T	24930608	4	4	81	1	0	0	0	0	0	1	0	0	10228	1291	45	3	2303	3	NCOA1	2	24930608	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	407576	24930608	218268765	29	24173										
GCKR	2646	broad.mit.edu	37	chr2	27746223	27746223	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctgcagctccttctgtctgtGaggctgtcaggagtgctctt	12	11	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:27746223G>C	uc002rky.2	+	19	1861	c.1795G>C	c.(1795-1797)GAG>CAG	p.E599Q	GCKR_uc010ezd.2_Missense_Mutation_p.E597Q|GCKR_uc010ylu.1_Missense_Mutation_p.E409Q	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	599					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					TTCTGTCTGTGAGGCTGTCAG	0.597													0	0	0	0.006214	0	10	37										C	27746223	G	C	27746223	3	2	81	1	0	0	0	0	1	0	0	0	6294	1291	45	1	1869	1	GCKR	2	27746223	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2815615	27746223	215453150	30	24174										
GCKR	2646	broad.mit.edu	37	chr2	27746258	27746258	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctcttgctgggccaggtcaGaagcgcactgcggaccccct	13	15	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:27746258G>C	uc002rky.2	+	19	1896	c.1830G>C	c.(1828-1830)CAG>CAC	p.Q610H	GCKR_uc010ezd.2_Missense_Mutation_p.Q608H|GCKR_uc010ylu.1_Missense_Mutation_p.Q420H	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	610					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					GGCCAGGTCAGAAGCGCACTG	0.612													0	0	0	0.001368	0	13	54										C	27746258	G	C	27746258	3	2	81	1	0	0	0	0	1	0	0	0	6294	933	33	1	1904	1	GCKR	2	27746258	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	35	27746258	215453115	31	24175										
SUPT7L	9913	broad.mit.edu	37	chr2	27884012	27884012	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccttctgtctgctgctgattCtgggcctgagctgtggcaat	12	11	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:27884012C>T	uc002rlh.1	-	3	601	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	SUPT7L_uc002rli.1_Silent_p.Q86Q|SUPT7L_uc010ymf.1_Intron|SUPT7L_uc002rlj.1_Silent_p.Q84Q|SUPT7L_uc010ezh.1_Silent_p.Q84Q|SLC4A1AP_uc002rlk.3_5'Flank	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	86					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					GCTGCTGATTCTGGGCCTGAG	0.517													0	0	0	0.003163	0	16	47										T	27884012	C	T	27884012	2	4	81	1	0	0	0	0	0	0	0	1	15398	912	32	1		1	SUPT7L	2	27884012	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	137754	27884012	215315361	32	24176										
CAPN13	92291	broad.mit.edu	37	chr2	30965216	30965216	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	attctgaggttgaaatggctGctcaggtgcctagaaaatca	11	7	3	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:30965216G>A	uc002rnn.2	-	13	1631	c.1455C>T	c.(1453-1455)AGC>AGT	p.S485S	CAPN13_uc002rnm.2_RNA|CAPN13_uc002rno.2_Silent_p.S39S	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	485					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TGAAATGGCTGCTCAGGTGCC	0.532													0	0	0	0.000602	0	5	8										A	30965216	G	A	30965216	2	1	81	1	0	0	0	0	0	0	0	1	2626	1310	46	2		2	CAPN13	2	30965216	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3081204	30965216	212234157	33	24177										
VPS54	51542	broad.mit.edu	37	chr2	64141357	64141357	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agtaagcatgtcagtagtaaCagatgggatgttatccacac	10	7	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:64141357C>G	uc002scq.2	-	17	2456	c.2293G>C	c.(2293-2295)GTT>CTT	p.V765L	VPS54_uc002scp.2_Missense_Mutation_p.V753L|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Missense_Mutation_p.V250L|VPS54_uc010fct.2_Missense_Mutation_p.V612L	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	765					protein transport|retrograde transport, endosome to Golgi						0						TCAGTAGTAACAGATGGGATG	0.348													0	0	0	0.002836	0	31	48										G	64141357	C	G	64141357	3	3	81	1	0	0	0	0	1	0	0	0	17213	478	17	4	668	4	VPS54	2	64141357	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	33176141	64141357	179058016	34	24178										
REG1B	5968	broad.mit.edu	37	chr2	79312402	79312402	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	caagattcatccttccatttCttgaatcctatggtacaatg	5	10	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:79312402C>G	uc002sny.2	-	6	553	c.441G>C	c.(439-441)AAG>AAC	p.K147N		NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	147	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						CCTTCCATTTCTTGAATCCTA	0.403													0	0	0	0.006214	0	9	18										G	79312402	C	G	79312402	3	3	81	1	0	0	0	0	1	0	0	0	13211	912	32	1	63	1	REG1B	2	79312402	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	15171045	79312402	163886971	35	24179										
MRPS5	64969	broad.mit.edu	37	chr2	95766234	95766234	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gttacctttgggttgtttctTcatcttgatatgcgtccttt	8	8	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:95766234T>A	uc002sub.2	-	10	1134	c.916A>T	c.(916-918)AAG>TAG	p.K306*	MRPS5_uc002suc.2_RNA	NM_031902	NP_114108	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	306					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3						GGTTGTTTCTTCATCTTGATA	0.323													0	0	0	0.006122	0	17	39										A	95766234	T	A	95766234	4	1	81	1	0	0	0	0	0	1	0	0	9846	1792	62	5	388	5	MRPS5	2	95766234	Nonsense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	16453832	95766234	147433139	36	24180										
LCT	3938	broad.mit.edu	37	chr2	136562346	136562346	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acccaccatacctggggctgGatgctggcggccagcagtgt	14	13	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:136562346G>T	uc002tuu.1	-	10	4466	c.4455C>A	c.(4453-4455)ATC>ATA	p.I1485I		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1485	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCTGGGGCTGGATGCTGGCGG	0.562													1	0	4.96729e-08	0.008871	5.09016e-08	18	41										T	136562346	G	T	136562346	2	4	81	1	0	0	0	0	0	0	0	1	8693	1164	41	3		3	LCT	2	136562346	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	40796112	136562346	106637027	37	24181										
NEB	4703	broad.mit.edu	37	chr2	152553231	152553231	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggtgaattttgtcttatctgGatggactttgtaggtgtgct	13	4	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:152553231G>C	uc010fnx.2	-	17	1680	c.1489C>G	c.(1489-1491)CCA>GCA	p.P497A	NEB_uc010fny.1_Missense_Mutation_p.P51A	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	497					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTCTTATCTGGATGGACTTTG	0.458													0	0	0	0.006214	0	10	26										C	152553231	G	C	152553231	3	2	81	1	0	0	0	0	1	0	0	0	10302	1174	41	1	24861	1	NEB	2	152553231	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	15990885	152553231	90646142	38	24182										
KBTBD10	10324	broad.mit.edu	37	chr2	170371102	170371102	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agctcgatagcatagcatctGaatgggttggacttccacct	10	10	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:170371102G>A	uc002ueu.1	+	2	1206	c.1129G>A	c.(1129-1131)GAA>AAA	p.E377K	KBTBD10_uc010zdh.1_Missense_Mutation_p.E315K	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	377	Kelch 1.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						CATAGCATCTGAATGGGTTGG	0.398													0	0	0	0.004656	0	24	33										A	170371102	G	A	170371102	3	1	81	1	0	0	0	0	1	0	0	0	7990	1291	45	1	1135	1	KBTBD10	2	170371102	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	17817871	170371102	72828271	39	24183										
NFE2L2	4780	broad.mit.edu	37	chr2	178098799	178098799	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctggctgaattgggagaaaTtcacctgtctcttcatctag	10	9	4	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:178098799T>A	uc002ulh.3	-	2	801	c.246A>T	c.(244-246)GAA>GAT	p.E82D	NFE2L2_uc002ulg.3_Missense_Mutation_p.E66D|NFE2L2_uc010zfa.1_Missense_Mutation_p.E66D|NFE2L2_uc002uli.3_Missense_Mutation_p.E66D|NFE2L2_uc010fra.2_Missense_Mutation_p.E66D|NFE2L2_uc010frb.2_Missense_Mutation_p.E66D	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	82					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTGGGAGAAATTCACCTGTCT	0.433			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.010504	0	20	33										A	178098799	T	A	178098799	3	1	81	1	0	0	0	0	1	0	0	0	10368	1490	52	5	1587	5	NFE2L2	2	178098799	Missense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	7727697	178098799	65100574	40	24184			2	108	153575767	2	2	12	N	T_C	8.421098e-05
NFE2L2	4780	broad.mit.edu	37	chr2	178098810	178098810	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgggagaaattcacctgtctCttcatctagttgtaactgag	9	8	4	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.004007	0	16	34										G	178098810	C	G	178098810	3	3	81	1	0	0	0	0	1	0	0	0	10368	922	32	1	1598	1	NFE2L2	2	178098810	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	11	178098810	65100563	41	24185			2	108	153575767	2	2	12	N	T_C	8.421098e-05
NGEF	25791	broad.mit.edu	37	chr2	233744322	233744324	+	In_Frame_Del	DEL	CTC	CTC	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cggatcttgggattcaagatCtcctcagtcatggagctggg							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:233744322_233744324delCTC	uc002vts.2	-	15	2256_2258	c.2008_2010delGAG	c.(2008-2010)GAGdel	p.E670del	NGEF_uc010zmm.1_In_Frame_Del_p.E393del|NGEF_uc010fyg.1_In_Frame_Del_p.E578del	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	670	SH3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GATTCAAGATCTCCTCAGTCATG	0.581																		44	106	---	---								-	233744324	CTC	-	233744322	7	5	81	1	0	1	0	1	0	0	0	0	10394	912	32	0	126	0	NGEF	2	233744322	In_Frame_Del	DEL	CTC	TCGA-FD-A3SM-01A-11D-A22Z-08	55645512	233744322	9455051	42	24186										
DUSP28	285193	broad.mit.edu	37	chr2	241500413	241500413	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctgcctagtctactgcaaGaacggccgcagccgctcggc	12	16	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:241500413G>C	uc002vzg.2	+	1	943	c.312G>C	c.(310-312)AAG>AAC	p.K104N	ANKMY1_uc002vzd.1_5'Flank|ANKMY1_uc010fze.1_5'Flank|ANKMY1_uc002vze.2_5'Flank|ANKMY1_uc002vzf.2_5'Flank|DUSP28_uc002vzh.2_Missense_Mutation_p.K104N	NM_001033575	NP_001028747	Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	104	Tyrosine-protein phosphatase.						protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		TCTACTGCAAGAACGGCCGCA	0.741													0	0	0	0.009096	0	4	12										C	241500413	G	C	241500413	3	2	81	1	0	0	0	0	1	0	0	0	4825	933	33	1	314	1	DUSP28	2	241500413	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	7756091	241500413	1698960	43	24187										
MLH1	4292	broad.mit.edu	37	chr3	37056007	37056007	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatgcaaactactcagtgaaGaagtgcatcttcttactctt	6	9	4	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:37056007G>C	uc003cgl.2	+	9	822	c.762G>C	c.(760-762)AAG>AAC	p.K254N	MLH1_uc011aye.1_Missense_Mutation_p.K13N|MLH1_uc011ayb.1_Missense_Mutation_p.K13N|MLH1_uc010hge.2_Missense_Mutation_p.K254N|MLH1_uc003cgn.3_Missense_Mutation_p.K13N|MLH1_uc011ayc.1_Missense_Mutation_p.K156N|MLH1_uc011ayd.1_Missense_Mutation_p.K13N|MLH1_uc003cgo.2_Missense_Mutation_p.K13N|MLH1_uc010hgg.1_5'UTR|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_5'UTR|MLH1_uc010hgl.1_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	254			Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						ACTCAGTGAAGAAGTGCATCT	0.383		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.006122	0	17	21										C	37056007	G	C	37056007	3	2	81	1	0	0	0	0	1	0	0	0	9617	933	33	1	796	1	MLH1	3	37056007	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		37056007	160966423	44	24188										
COL7A1	1294	broad.mit.edu	37	chr3	48622525	48622525	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggcgcggccagggctgcctgGacgcccatctgctccaggga	16	15	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:48622525G>C	uc003ctz.2	-	32	3920	c.3919C>G	c.(3919-3921)CCA>GCA	p.P1307A		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1307	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGGCTGCCTGGACGCCCATCT	0.682													0	0	0	0.006122	0	16	41										C	48622525	G	C	48622525	3	2	81	1	0	0	0	0	1	0	0	0	3704	1174	41	1	5263	1	COL7A1	3	48622525	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	11566518	48622525	149399905	45	24189										
COL7A1	1294	broad.mit.edu	37	chr3	48622544	48622544	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggacgcccatctgctccaggGaagccctgaggaggtgaaga	15	11	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:48622544G>A	uc003ctz.2	-	32	3901	c.3900C>T	c.(3898-3900)TTC>TTT	p.F1300F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1300	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGCTCCAGGGAAGCCCTGAG	0.667													0	0	0	0.000978	0	12	37										A	48622544	G	A	48622544	2	1	81	1	0	0	0	0	0	0	0	1	3704	1165	41	1		1	COL7A1	3	48622544	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	19	48622544	149399886	46	24190										
PPM1M	132160	broad.mit.edu	37	chr3	52282393	52282393	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tggctggtgagttcacccgaCtggagttccctcggcggctg	15	12	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:52282393C>G	uc003ddf.3	+	6	720	c.355C>G	c.(355-357)CTG>GTG	p.L119V	PPM1M_uc011bed.1_Missense_Mutation_p.L280V|PPM1M_uc010hmd.2_Missense_Mutation_p.L119V|PPM1M_uc003ddg.3_Missense_Mutation_p.L68V|PPM1M_uc003ddh.3_5'Flank			Q96MI6	PPM1M_HUMAN	RecName: Full=Protein phosphatase 1M;          EC=3.1.3.16; AltName: Full=Protein phosphatase 2C isoform eta;          Short=PP2C-eta;          Short=PP2CE;	119	PP2C-like.				protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding				0				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		GTTCACCCGACTGGAGTTCCC	0.592													0	0	0	0.004482	0	9	23										G	52282393	C	G	52282393	3	3	81	1	0	0	0	0	1	0	0	0	12345	564	20	4	369	4	PPM1M	3	52282393	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	3659849	52282393	145740037	47	24191										
C3orf63	23272	broad.mit.edu	37	chr3	56680888	56680888	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	taaactgctgaagttttctaTtttcttcaaatagttctttt	4	6	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:56680888T>C	uc003did.3	-	14	1978	c.1877A>G	c.(1876-1878)AAT>AGT	p.N626S	C3orf63_uc003dic.3_Missense_Mutation_p.N230S|C3orf63_uc003die.3_Missense_Mutation_p.N626S	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	626										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		AAGTTTTCTATTTTCTTCAAA	0.299													0	0	0	0.004482	0	9	25										C	56680888	T	C	56680888	3	2	81	1	0	0	0	0	1	0	0	0	2239	1493	52	5	3239	5	C3orf63	3	56680888	Missense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	4398495	56680888	141341542	48	24192										
PDE12	201626	broad.mit.edu	37	chr3	57543222	57543222	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gaggccttcgggctcgagggGgtgtttcgaatcaagcagca	16	9	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:57543222G>A	uc003diw.3	+	1	1242	c.1116G>A	c.(1114-1116)GGG>GGA	p.G372G	PDE12_uc003div.2_Silent_p.G372G	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	372							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GGCTCGAGGGGGTGTTTCGAA	0.547													0	0	0	0.008291	0	11	42										A	57543222	G	A	57543222	2	1	81	1	0	0	0	0	0	0	0	1	11632	1219	43	2		2	PDE12	3	57543222	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	862334	57543222	140479208	49	24193										
FAM116A	201627	broad.mit.edu	37	chr3	57619051	57619051	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcgtcgaagaataacactttGagcctcagaaggacgtttct	10	9	2	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:57619051G>C	uc003dja.2	-	15	1365	c.1294C>G	c.(1294-1296)CAA>GAA	p.Q432E		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	432										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		ATAACACTTTGAGCCTCAGAA	0.303													0	0	0	0.003163	0	14	33										C	57619051	G	C	57619051	3	2	81	1	0	0	0	0	1	0	0	0	5407	1299	45	1	556	1	FAM116A	3	57619051	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	75829	57619051	140403379	50	24194										
PSMD6	9861	broad.mit.edu	37	chr3	64009039	64009039	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agcaggaagcgcagctgcgcGatacgcaagtcggggttctt	15	10	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:64009039G>C	uc003dma.1	-	1	82	c.57C>G	c.(55-57)ATC>ATG	p.I19M	PSMD6_uc003dlz.1_Translation_Start_Site|PSMD6_uc003dmb.1_Missense_Mutation_p.I19M|PSMD6_uc003dmc.1_Intron|PSMD6_uc003dmd.1_Intron	NM_014814	NP_055629	Q15008	PSMD6_HUMAN	proteasome (prosome, macropain) 26S subunit,	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|skin(1)	2		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		GCAGCTGCGCGATACGCAAGT	0.672													0	0	0	0.001368	0	12	17										C	64009039	G	C	64009039	3	2	81	1	0	0	0	0	1	0	0	0	12702	1048	37	1	1144	1	PSMD6	3	64009039	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	6389988	64009039	134013391	51	24195										
IQCB1	9657	broad.mit.edu	37	chr3	121491473	121491473	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtgctgctgggctcgctcttCtagggccctgcccataaagt	12	13	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:121491473C>G	uc010hre.1	-	14	1713	c.1498G>C	c.(1498-1500)GAA>CAA	p.E500Q	IQCB1_uc003eek.2_Missense_Mutation_p.E367Q|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	500					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		GCTCGCTCTTCTAGGGCCCTG	0.498													0	0	0	0.009718	0	41	84										G	121491473	C	G	121491473	3	3	81	1	0	0	0	0	1	0	0	0	7803	922	32	1	306	1	IQCB1	3	121491473	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	57482434	121491473	76530957	52	24196										
DIRC2	84925	broad.mit.edu	37	chr3	122598123	122598123	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cttacagagttgtcttggttCaactggtgccttcccgggtc	11	11	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:122598123C>T	uc003efw.3	+	9	1474	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Silent_p.F283F|uc003efx.1_RNA	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	445	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		TGTCTTGGTTCAACTGGTGCC	0.463													0	0	0	0.00361	0	103	189										T	122598123	C	T	122598123	2	4	81	1	0	0	0	0	0	0	0	1	4534	825	29	1		1	DIRC2	3	122598123	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1106650	122598123	75424307	53	24197										
IFT122	55764	broad.mit.edu	37	chr3	129185821	129185821	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttcaggaaatcccttccactCtgaagtcagcagtgtacagt	8	11	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:129185821C>G	uc003emm.2	+	8	858	c.652C>G	c.(652-654)CTG>GTG	p.L218V	IFT122_uc003eml.2_Missense_Mutation_p.L269V|IFT122_uc003emn.2_Intron|IFT122_uc003emo.2_Intron|IFT122_uc003emp.2_Missense_Mutation_p.L68V|IFT122_uc010htc.2_Intron|IFT122_uc011bky.1_Intron|IFT122_uc003emq.2_Intron|IFT122_uc003emr.2_Intron|IFT122_uc011bla.1_Intron|IFT122_uc011bkx.1_Intron|IFT122_uc011bkz.1_Intron	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	218					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CCCTTCCACTCTGAAGTCAGC	0.498													0	0	0	0.002836	0	33	64										G	129185821	C	G	129185821	3	3	81	1	0	0	0	0	1	0	0	0	7555	912	32	1	839	1	IFT122	3	129185821	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	6587698	129185821	68836609	54	24198										
DNAJC13	23317	broad.mit.edu	37	chr3	132182552	132182552	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttccaaaggaaggtgataaaGaaattgctacaaaaatgcag	9	5	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:132182552G>C	uc003eor.2	+	17	1848	c.1783G>C	c.(1783-1785)GAA>CAA	p.E595Q	DNAJC13_uc010htq.1_Missense_Mutation_p.E595Q	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	595							heat shock protein binding			ovary(1)|breast(1)	2						AGGTGATAAAGAAATTGCTAC	0.383													0	0	0	0.004656	0	24	42										C	132182552	G	C	132182552	3	2	81	1	0	0	0	0	1	0	0	0	4632	943	33	1	1845	1	DNAJC13	3	132182552	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2996731	132182552	65839878	55	24199										
XRN1	54464	broad.mit.edu	37	chr3	142144273	142144273	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ataaaaaaagataataacctCatggcctgagaagtagatgg	9	5	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:142144273C>T	uc003eus.2	-	4	581	c.514G>A	c.(514-516)GAG>AAG	p.E172K	XRN1_uc003eut.2_Missense_Mutation_p.E172K|XRN1_uc003euu.2_Missense_Mutation_p.E172K|XRN1_uc003euv.1_Missense_Mutation_p.E33K|XRN1_uc003euw.2_Missense_Mutation_p.E172K|XRN1_uc011bnh.1_Intron	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	172					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATAATAACCTCATGGCCTGAG	0.279													0	0	0	0.00499	0	17	6										T	142144273	C	T	142144273	3	4	81	1	0	0	0	0	1	0	0	0	17456	835	29	1	4762	1	XRN1	3	142144273	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	9961721	142144273	55878157	56	24200										
KLHL24	54800	broad.mit.edu	37	chr3	183368537	183368537	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tatactggaaaggtgaagatCactacagagaatgtacagta	10	5	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:183368537C>T	uc003flv.2	+	3	688	c.393C>T	c.(391-393)ATC>ATT	p.I131I	KLHL24_uc003flw.2_Silent_p.I131I|KLHL24_uc003flx.2_Silent_p.I131I	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	131	BTB.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			AGGTGAAGATCACTACAGAGA	0.408													0	0	0	0.001984	0	6	137										T	183368537	C	T	183368537	2	4	81	1	0	0	0	0	0	0	0	1	8379	816	29	1		1	KLHL24	3	183368537	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	41224264	183368537	14653893	57	24201										
C3orf43	255798	broad.mit.edu	37	chr3	196236536	196236536	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	taacgcttggagtttgtggtCtactctgtaggataacagaa	11	6	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:196236536C>G	uc003fws.2	-	2	212	c.55G>C	c.(55-57)GAC>CAC	p.D19H	C3orf43_uc003fwr.2_Missense_Mutation_p.D11H	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	19	Potential.					integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		AGTTTGTGGTCTACTCTGTAG	0.373													0	0	0	0.00361	0	46	86										G	196236536	C	G	196236536	3	3	81	1	0	0	0	0	1	0	0	0	2230	913	32	1	597	1	C3orf43	3	196236536	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	12867999	196236536	1785894	58	24202										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.001368	0	11	19										G	1803568	C	G	1803568	3	3	81	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		1803568	189350708	59	24203										
EVC	2121	broad.mit.edu	37	chr4	5754566	5754566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgtgtttctttttgcaggacGccctggagaggacgatgggg	16	7	1	1	rs145645536		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:5754566G>A	uc003gil.1	+	9	1286	c.1102G>A	c.(1102-1104)GCC>ACC	p.A368T	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	368					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TTTGCAGGACGCCCTGGAGAG	0.557													0	0	0	0.006999	0	39	64										A	5754566	G	A	5754566	3	1	81	1	0	0	0	0	1	0	0	0	5285	1087	38	2	1136	2	EVC	4	5754566	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3950998	5754566	185399710	60	24204										
ADAMTS3	9508	broad.mit.edu	37	chr4	73185578	73185578	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgtcagcagtgacttacacaTggcccgtttcatgggctact	10	11	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:73185578T>C	uc003hgk.1	-	8	1242	c.1205A>G	c.(1204-1206)CAT>CGT	p.H402R		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	402	Peptidase M12B.	Zinc; catalytic (By similarity).			collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GACTTACACATGGCCCGTTTC	0.448													0	0	0	0.006122	0	18	26										C	73185578	T	C	73185578	3	2	81	1	0	0	0	0	1	0	0	0	267	1464	51	5	2472	5	ADAMTS3	4	73185578	Missense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	67431012	73185578	117968698	61	24205										
AFF1	4299	broad.mit.edu	37	chr4	88053553	88053553	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cccaggcaccttctccatgcAttgcaaggtaactctaagtc	7	14	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:88053553A>G	uc003hqj.3	+	18	3690	c.3283A>G	c.(3283-3285)ATT>GTT	p.I1095V	AFF1_uc011ccz.1_Missense_Mutation_p.I1102V|AFF1_uc003hqk.3_Missense_Mutation_p.I1095V|AFF1_uc011cda.1_Missense_Mutation_p.I733V	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1095						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TTCTCCATGCATTGCAAGGTA	0.343													0	0	0	0.006122	0	17	25										G	88053553	A	G	88053553	3	3	81	1	0	0	0	0	1	0	0	0	356	217	8	5	3395	5	AFF1	4	88053553	Missense_Mutation	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	14867975	88053553	103100723	62	24206										
DDIT4L	115265	broad.mit.edu	37	chr4	101109268	101109268	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	attctggcaagttgattcctCaaatattacctcgttgaggt	8	8	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:101109268C>T	uc003hvq.2	-	3	351	c.148G>A	c.(148-150)GAG>AAG	p.E50K		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	50					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)		GTTGATTCCTCAAATATTACC	0.368													0	0	0	0.009718	0	45	72										T	101109268	C	T	101109268	3	4	81	1	0	0	0	0	1	0	0	0	4332	835	29	1	437	1	DDIT4L	4	101109268	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	13055715	101109268	90045008	63	24207										
PCDH10	57575	broad.mit.edu	37	chr4	134072260	134072260	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gttggactatgaagagagccCagtgtaccaagtgtacgtgc	13	8	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:134072260C>G	uc003iha.2	+	1	1791	c.965C>G	c.(964-966)CCA>CGA	p.P322R	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.P322R	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	322	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GAAGAGAGCCCAGTGTACCAA	0.612													0	0	0	0.002852	0	41	78										G	134072260	C	G	134072260	3	3	81	1	0	0	0	0	1	0	0	0	11507	594	21	4	967	4	PCDH10	4	134072260	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	32962992	134072260	57082016	64	24208										
TLR2	7097	broad.mit.edu	37	chr4	154625251	154625251	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctttaattttaaggcaaaatCatttggcatcattggaaaaa	6	5	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:154625251C>G	uc003inq.2	+	3	1411	c.1192C>G	c.(1192-1194)CAT>GAT	p.H398D	TLR2_uc003inr.2_Missense_Mutation_p.H398D|TLR2_uc003ins.2_Missense_Mutation_p.H398D	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	398	LRR 9.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				AAGGCAAAATCATTTGGCATC	0.363													0	0	0	0.007413	0	19	47										G	154625251	C	G	154625251	3	3	81	1	0	0	0	0	1	0	0	0	15948	826	29	1	1194	1	TLR2	4	154625251	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	20552991	154625251	36529025	65	24209										
MARCH6	10299	broad.mit.edu	37	chr5	10402684	10402684	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tagaaattggagtattccctCtcatttgtggttggtggctg	12	6	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:10402684C>G	uc003jet.1	+	14	1345	c.1162C>G	c.(1162-1164)CTC>GTC	p.L388V	MARCH6_uc011cmu.1_Missense_Mutation_p.L340V|MARCH6_uc003jeu.1_Missense_Mutation_p.L86V|MARCH6_uc011cmv.1_Missense_Mutation_p.L283V	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	388	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						AGTATTCCCTCTCATTTGTGG	0.358													0	0	0	0.00361	0	86	183										G	10402684	C	G	10402684	3	3	81	1	0	0	0	0	1	0	0	0	9305	913	32	1	1216	1	MARCH6	5	10402684	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		10402684	170512576	66	24210										
FAM151B	167555	broad.mit.edu	37	chr5	79797732	79797732	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcacaaacaaatgaggcactGaaaagtaagtcagtacagtt	9	7	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:79797732G>C	uc003kgv.1	+	2	290	c.147G>C	c.(145-147)CTG>CTC	p.L49L	FAM151B_uc010jal.1_RNA	NM_205548	NP_991111	Q6UXP7	F151B_HUMAN	hypothetical protein LOC167555	49											0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		ATGAGGCACTGAAAAGTAAGT	0.368													0	0	0	0.007835	0	39	33										C	79797732	G	C	79797732	2	2	81	1	0	0	0	0	0	0	0	1	5459	1277	45	1		1	FAM151B	5	79797732	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	69395048	79797732	101117528	67	24211										
EFNA5	1946	broad.mit.edu	37	chr5	106722987	106722987	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gttaacatcgaaaacacgatCatgaacacctatagttttca	5	9	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:106722987C>A	uc003kol.2	-	4	796	c.514G>T	c.(514-516)GAT>TAT	p.D172Y		NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	172					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		AAAACACGATCATGAACACCT	0.318													1	0	0.00010058	0.001368	0.000101631	8	7										A	106722987	C	A	106722987	3	1	81	1	0	0	0	0	1	0	0	0	4954	826	29	3	180	3	EFNA5	5	106722987	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	26925255	106722987	74192273	68	24212										
MAN2A1	4124	broad.mit.edu	37	chr5	109051929	109051929	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatgggacactgaaccccttCaagtctttgtggtgcctcat	9	11	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:109051929C>G	uc003kou.1	+	3	1462	c.499C>G	c.(499-501)CAA>GAA	p.Q167E		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	167	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TGAACCCCTTCAAGTCTTTGT	0.378													0	0	0	0.00278	0	24	26										G	109051929	C	G	109051929	3	3	81	1	0	0	0	0	1	0	0	0	9214	827	29	1	509	1	MAN2A1	5	109051929	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2328942	109051929	71863331	69	24213										
LARS	51520	broad.mit.edu	37	chr5	145557190	145557190	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgttggatttctttctcaatCttcttcaaaaagtccacttt	4	9	5	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:145557190C>G	uc003lnx.1	-	2	283	c.45G>C	c.(43-45)AAG>AAC	p.K15N	LARS_uc011dbq.1_Missense_Mutation_p.K15N|LARS_uc011dbr.1_Intron|LARS_uc011dbs.1_Missense_Mutation_p.K15N	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	15					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CTTTCTCAATCTTCTTCAAAA	0.363													0	0	0	0.010504	0	20	16										G	145557190	C	G	145557190	3	3	81	1	0	0	0	0	1	0	0	0	8634	912	32	1	3609	1	LARS	5	145557190	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	36505261	145557190	35358070	70	24214										
ZNF454	285676	broad.mit.edu	37	chr5	178392337	178392337	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttgtgaaaaagcctttgtgtGcagggcacaccttaccaaac	9	10	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:178392337G>T	uc003mjo.1	+	5	1203	c.932G>T	c.(931-933)TGC>TTC	p.C311F	ZNF454_uc010jkz.1_Missense_Mutation_p.C311F	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	311	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		GCCTTTGTGTGCAGGGCACAC	0.378													1	0	7.33628e-21	0.002299	7.79312e-21	21	22										T	178392337	G	T	178392337	3	4	81	1	0	0	0	0	1	0	0	0	17920	1319	46	4	946	4	ZNF454	5	178392337	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	32835147	178392337	2522923	71	24215										
HIST1H2AK	8330	broad.mit.edu	37	chr6	27805964	27805964	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtactccaacaccgccgccaGgtacaccggcgctccggcac	10	19	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:27805964G>A	uc003njs.2	-	1	154	c.154C>T	c.(154-156)CTG>TTG	p.L52L	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	52					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						ACCGCCGCCAGGTACACCGGC	0.652													0	0	0	0.009096	0	4	63										A	27805964	G	A	27805964	2	1	81	1	0	0	0	0	0	0	0	1	7137	991	35	2		2	HIST1H2AK	6	27805964	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		27805964	143309103	72	24216										
CFB	629	broad.mit.edu	37	chr6	31895930	31895930	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cacccggtctctgtctaaggCggtctgcaaacgtgaggctc	12	13	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:31895930C>T	uc011dor.1	+	2	509	c.245C>T	c.(244-246)GCG>GTG	p.A82V	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_Intron|C2_uc003nye.3_Missense_Mutation_p.A82V|C2_uc003nyf.2_Missense_Mutation_p.A82V|C2_uc010jtk.2_Intron|C2_uc011doq.1_Missense_Mutation_p.R44W|C2_uc003nyg.2_Intron	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	156	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CTGTCTAAGGCGGTCTGCAAA	0.473													0	0	0	0.004672	0	3	13										T	31895930	C	T	31895930	3	4	81	1	0	0	0	0	1	0	0	0	3278	768	27	2		2	CFB	6	31895930	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	4089966	31895930	139219137	73	24217										
UHRF1BP1	54887	broad.mit.edu	37	chr6	34824635	34824635	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agggcagacagcctgcctttCagcctccagcatggaaccgc	11	15	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:34824635C>T	uc003oju.3	+	11	1594	c.1360C>T	c.(1360-1362)CAG>TAG	p.Q454*	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_5'Flank	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	454										ovary(3)	3						GCCTGCCTTTCAGCCTCCAGC	0.502													0	0	0	0.00278	0	22	47										T	34824635	C	T	34824635	4	4	81	1	0	0	0	0	0	1	0	0	16965	827	29	1	1402	1	UHRF1BP1	6	34824635	Nonsense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2928705	34824635	136290432	74	24218										
CDKN1A	1026	broad.mit.edu	37	chr6	36652009	36652010	+	Frame_Shift_Ins	INS	-	-	GG													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atggcgggctgcatccaggaINSggcccgtgagcgatggaact							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			-	GG	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:36652009_36652010insGG	uc003omm.3	+	2	253_254	c.131_132insGG	c.(130-132)GAGfs	p.E44fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E78fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E44fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E44fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	44					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						TGCATCCAGGAGGCCCGTGAGC	0.658									Multiple_Endocrine_Neoplasia_type_1									17	40	---	---								GG	36652010	-	GG	36652009	7	5	81	1	0	1	1	0	0	0	0	0	3158	304	11	0	133	0	CDKN1A	6	36652009	Frame_Shift_Ins	INS	-	TCGA-FD-A3SM-01A-11D-A22Z-08	1827374	36652009	134463058	75	24219										
DAAM2	23500	broad.mit.edu	37	chr6	39828707	39828707	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcttattgtctttgcaggatGaattggatctcactgacaaa	8	7	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:39828707G>A	uc003oow.2	+	3	328	c.172G>A	c.(172-174)GAA>AAA	p.E58K	DAAM2_uc010jxc.2_Missense_Mutation_p.E58K|DAAM2_uc003oox.2_Missense_Mutation_p.E58K|DAAM2_uc003oov.3_Missense_Mutation_p.E58K|DAAM2_uc003ooy.3_Missense_Mutation_p.E58K	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	58	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TTTGCAGGATGAATTGGATCT	0.448													0	0	0	0.004482	0	9	15										A	39828707	G	A	39828707	3	1	81	1	0	0	0	0	1	0	0	0	4216	1291	45	1	178	1	DAAM2	6	39828707	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3176698	39828707	131286360	76	24220										
UNC5CL	222643	broad.mit.edu	37	chr6	40996310	40996316	+	Frame_Shift_Del	DEL	GGGGCTG	GGGGCTG	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aactccaggatggccgctgcGgggctgcgctggcaggacag							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:40996310_40996316delGGGGCTG	uc003opi.2	-	9	1442_1448	c.1353_1359delCAGCCCC	c.(1351-1359)CGCAGCCCCfs	p.R451fs		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	451_453	Death.|Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGCCGCTGCGGGGCTGCGCTGGCAGG	0.671																		12	66	---	---								-	40996316	GGGGCTG	-	40996310	7	5	81	1	0	1	0	1	0	0	0	0	16991	1103	39	0	201	0	UNC5CL	6	40996310	Frame_Shift_Del	DEL	GGGGCTG	TCGA-FD-A3SM-01A-11D-A22Z-08	1167603	40996310	130118757	77	24221										
DST	667	broad.mit.edu	37	chr6	56492874	56492874	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatctttctctgagtagtttCaacctgctggatccaatcat	6	10	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:56492874C>T	uc003pdf.2	-	32	4490	c.4462G>A	c.(4462-4464)GAA>AAA	p.E1488K	DST_uc003pcz.3_Missense_Mutation_p.E1310K|DST_uc011dxj.1_Missense_Mutation_p.E1339K|DST_uc011dxk.1_Missense_Mutation_p.E1350K|DST_uc003pcy.3_Missense_Mutation_p.E984K|DST_uc003pdb.2_Missense_Mutation_p.E984K|DST_uc003pdc.3_Missense_Mutation_p.E984K|DST_uc003pdd.3_Missense_Mutation_p.E984K	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1310					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGAGTAGTTTCAACCTGCTGG	0.388													0	0	0	0.00278	0	21	48										T	56492874	C	T	56492874	3	4	81	1	0	0	0	0	1	0	0	0	4783	835	29	1	17469	1	DST	6	56492874	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	15496564	56492874	114622193	78	24222										
KCNQ5	56479	broad.mit.edu	37	chr6	73751677	73751677	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aggagttcgtgatgattgtcGtctttggtttggagttcatc	13	5	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:73751677G>A	uc003pgk.2	+	3	855	c.508G>A	c.(508-510)GTC>ATC	p.V170I	KCNQ5_uc003pgj.3_Missense_Mutation_p.V170I|KCNQ5_uc011dyh.1_Missense_Mutation_p.V170I|KCNQ5_uc011dyi.1_Missense_Mutation_p.V170I|KCNQ5_uc010kat.2_Missense_Mutation_p.V170I|KCNQ5_uc011dyj.1_Missense_Mutation_p.V170I|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	170	Helical; Name=Segment S2; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GATGATTGTCGTCTTTGGTTT	0.423													0	0	0	0.00361	0	71	141										A	73751677	G	A	73751677	3	1	81	1	0	0	0	0	1	0	0	0	8086	1145	40	2	518	2	KCNQ5	6	73751677	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	17258803	73751677	97363390	79	24223										
MDN1	23195	broad.mit.edu	37	chr6	90402857	90402857	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atccagccgatccatcctttGgcgaagcagcctaacgggaa	10	13	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:90402857G>A	uc003pnn.1	-	63	10008	c.9892C>T	c.(9892-9894)CAA>TAA	p.Q3298*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3298					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCATCCTTTGGCGAAGCAGC	0.473													0	0	0	0.00308	0	8	26										A	90402857	G	A	90402857	4	1	81	1	0	0	0	0	0	1	0	0	9415	1357	47	2	7058	2	MDN1	6	90402857	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	16651180	90402857	80712210	80	24224										
C6orf167	253714	broad.mit.edu	37	chr6	97626386	97626386	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatattcaacttgggcctttGagaaaatactctttacttct	5	8	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:97626386G>A	uc003ppb.2	-	18	2878	c.2612C>T	c.(2611-2613)TCA>TTA	p.S871L	C6orf167_uc011eaf.1_Missense_Mutation_p.S831L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	871					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		TTGGGCCTTTGAGAAAATACT	0.299													0	0	0	0.003163	0	14	46										A	97626386	G	A	97626386	3	1	81	1	0	0	0	0	1	0	0	0	2342	1294	45	1	1151	1	C6orf167	6	97626386	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	7223529	97626386	73488681	81	24225										
COQ3	51805	broad.mit.edu	37	chr6	99823896	99823896	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttcagaagctacaacagcatCaaatgtttctgcagtctctt	6	10	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:99823896C>G	uc003ppk.2	-	5	676	c.649G>C	c.(649-651)GAT>CAT	p.D217H		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	217					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity	p.D217H(1)		upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		ACAACAGCATCAAATGTTTCT	0.388													0	0	0	0.00623	0	40	116										G	99823896	C	G	99823896	3	3	81	1	0	0	0	0	1	0	0	0	3746	826	29	1	472	1	COQ3	6	99823896	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2197510	99823896	71291171	82	24226										
SIM1	6492	broad.mit.edu	37	chr6	100896129	100896129	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	accccgtcagctccgccaccCtgaggagagcaatccctgca	9	18	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:100896129C>G	uc003pqj.3	-	7	951	c.744_splice	c.e7-1	p.R248_splice	SIM1_uc010kcu.2_Splice_Site_p.R248_splice	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1						cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTCCGCCACCCTGAGGAGAGC	0.637													0	0	0	0.009096	0	4	25										G	100896129	C	G	100896129	5	3	81	1	0	0	0	0	0	0	1	0	14323	695	24	4	1577	4	SIM1	6	100896129	Splice_Site	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1072233	100896129	70218938	83	24227										
LAMA4	3910	broad.mit.edu	37	chr6	112476059	112476059	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtgaagatatttactagactCtgcctttgcttgcagttctc	8	9	2	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:112476059C>G	uc003pvu.2	-	16	2359	c.2050G>C	c.(2050-2052)GAG>CAG	p.E684Q	LAMA4_uc003pvv.2_Missense_Mutation_p.E677Q|LAMA4_uc003pvt.2_Missense_Mutation_p.E677Q	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	684	Domain II and I.|Potential.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTACTAGACTCTGCCTTTGCT	0.393													0	0	0	0.005443	0	25	58										G	112476059	C	G	112476059	3	3	81	1	0	0	0	0	1	0	0	0	8608	922	32	1	3517	1	LAMA4	6	112476059	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	11579930	112476059	58639008	84	24228										
VNN2	8875	broad.mit.edu	37	chr6	133073771	133073771	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttcaccagggtaacaccagGatcatagaagaatatatcaa	7	8	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:133073771G>T	uc003qdt.2	-	4	666	c.655C>A	c.(655-657)CCT>ACT	p.P219T	VNN2_uc003qds.2_Intron|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Missense_Mutation_p.P166T	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	219	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GTAACACCAGGATCATAGAAG	0.438													1	0	9.84934e-19	0.002522	1.04245e-18	45	109										T	133073771	G	T	133073771	3	4	81	1	0	0	0	0	1	0	0	0	17180	1174	41	3	923	3	VNN2	6	133073771	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	20597712	133073771	38041296	85	24229										
THBS2	7058	broad.mit.edu	37	chr6	169623541	169623541	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gatgttgtcattgtcaaaatCatctttacaaatatcacccc	4	10	5	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:169623541C>T	uc003qwt.2	-	19	3051	c.2803G>A	c.(2803-2805)GAT>AAT	p.D935N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	935	TSP type-3 8.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTGTCAAAATCATCTTTACAA	0.393													0	0	0	0.007291	0	28	54										T	169623541	C	T	169623541	3	4	81	1	0	0	0	0	1	0	0	0	15851	826	29	1	735	1	THBS2	6	169623541	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	36549770	169623541	1491526	86	24230										
SUN1	23353	broad.mit.edu	37	chr7	883137	883137	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcccgtgtcgagagtttattCtagggacaggaatcaaaaat	11	7	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:883137C>G	uc011jvp.1	+	6	717	c.638C>G	c.(637-639)TCT>TGT	p.S213C	SUN1_uc010ksa.1_Missense_Mutation_p.S234C|SUN1_uc003sje.1_Missense_Mutation_p.S213C|SUN1_uc003sjf.2_Missense_Mutation_p.S163C|SUN1_uc011jvq.1_Intron|SUN1_uc003sjg.2_Missense_Mutation_p.S24C	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	213	SYNE2-binding.|Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						AGAGTTTATTCTAGGGACAGG	0.502													0	0	0	0.00361	0	79	186										G	883137	C	G	883137	3	3	81	1	0	0	0	0	1	0	0	0	15388	913	32	1	723	1	SUN1	7	883137	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		883137	158255526	87	24231										
KIAA0415	9907	broad.mit.edu	37	chr7	4830402	4830402	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gccctggaggctctgctattCgaggtcacccagtgccgccc	12	16	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:4830402C>T	uc003sne.2	+	16	2120	c.2037C>T	c.(2035-2037)TTC>TTT	p.F679F	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Silent_p.F156F	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	679					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		CTCTGCTATTCGAGGTCACCC	0.647													0	0	0	0.00308	0	8	11										T	4830402	C	T	4830402	2	4	81	1	0	0	0	0	0	0	0	1	8175	883	31	1		1	KIAA0415	7	4830402	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	3947265	4830402	154308261	88	24232										
C7orf28A	51622	broad.mit.edu	37	chr7	5942310	5942310	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agctttttaatggtacatttCtgaaagccatggaagacgga	10	6	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:5942310C>G	uc003spf.2	+	6	547	c.457C>G	c.(457-459)CTG>GTG	p.L153V		NM_015622	NP_056437	P86791	CCZ1_HUMAN	hypothetical protein LOC51622	153				LKAMEDGGVK -> PESHGRRRVQ (in Ref. 1; AAD34038).		lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)		TGGTACATTTCTGAAAGCCAT	0.323													0	0	0	0.005443	0	19	33										G	5942310	C	G	5942310	3	3	81	1	0	0	0	0	1	0	0	0	2383	912	32	1	479	1	C7orf28A	7	5942310	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1111908	5942310	153196353	89	24233										
ABCA13	154664	broad.mit.edu	37	chr7	48312697	48312697	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	caacaagtttatgtccattcActgtaccgtttcatggcttc	6	11	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:48312697A>G	uc003toq.2	+	17	3459	c.3434A>G	c.(3433-3435)CAC>CGC	p.H1145R	ABCA13_uc010kyr.2_Missense_Mutation_p.H648R	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1145					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATGTCCATTCACTGTACCGTT	0.353													0	0	0	0.006122	0	15	43										G	48312697	A	G	48312697	3	3	81	1	0	0	0	0	1	0	0	0	31	159	6	5	3329	5	ABCA13	7	48312697	Missense_Mutation	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	42370387	48312697	110825966	90	24234										
ASL	435	broad.mit.edu	37	chr7	65548157	65548157	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggaccatggtggatcgggcaGaggcgtgagtcctacaggga	18	8	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:65548157G>C	uc003tuo.2	+	6	553	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	ASL_uc011kdu.1_Missense_Mutation_p.E148Q|ASL_uc010kzx.1_3'UTR|ASL_uc011kdv.1_Missense_Mutation_p.E148Q|ASL_uc003tup.2_Missense_Mutation_p.E148Q|ASL_uc003tur.2_Missense_Mutation_p.E148Q|ASL_uc003tuq.2_Missense_Mutation_p.E148Q	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	148					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	GGATCGGGCAGAGGCGTGAGT	0.637													0	0	0	0.004007	0	16	22										C	65548157	G	C	65548157	3	2	81	1	0	0	0	0	1	0	0	0	1044	943	33	1	460	1	ASL	7	65548157	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	17235460	65548157	93590506	91	24235										
CYP3A4	1576	broad.mit.edu	37	chr7	99367796	99367796	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gacagcaatgatcgtaatctCttccattcttcatcctcagc	5	13	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:99367796C>T	uc003urv.1	-	5	485	c.381G>A	c.(379-381)AAG>AAA	p.K127K	CYP3A4_uc003urw.1_Silent_p.K127K|CYP3A4_uc011kiz.1_Intron|CYP3A4_uc011kja.1_Silent_p.K78K|CYP3A4_uc011kjb.1_Intron	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	127					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	ATCGTAATCTCTTCCATTCTT	0.378													0	0	0	0.003271	0	34	58										T	99367796	C	T	99367796	2	4	81	1	0	0	0	0	0	0	0	1	4178	912	32	1		1	CYP3A4	7	99367796	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	33819639	99367796	59770867	92	24236										
UBN2	254048	broad.mit.edu	37	chr7	138968238	138968238	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttattgctggttcttccattCagaaccctaaagtttcttta	5	9	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:138968238C>G	uc011kqr.1	+	15	2587	c.2587C>G	c.(2587-2589)CAG>GAG	p.Q863E		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	863										ovary(1)|skin(1)	2						TTCTTCCATTCAGAACCCTAA	0.463													0	0	0	0.006999	0	42	66										G	138968238	C	G	138968238	3	3	81	1	0	0	0	0	1	0	0	0	16890	827	29	1	2645	1	UBN2	7	138968238	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	39600442	138968238	20170425	93	24237										
ZNF777	27153	broad.mit.edu	37	chr7	149152725	149152725	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tctcaggagcttcaggggagTgaacgggggcttcctggtgg	18	8	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:149152725T>G	uc003wfv.2	-	2	552	c.389A>C	c.(388-390)CAC>CCC	p.H130P		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TTCAGGGGAGTGAACGGGGGC	0.612													0	0	0	0.00361	0	98	192										G	149152725	T	G	149152725	3	3	81	1	0	0	0	0	1	0	0	0	18147	1696	59	5	2126	5	ZNF777	7	149152725	Missense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	10184487	149152725	9985938	94	24238										
NOS3	4846	broad.mit.edu	37	chr7	150699002	150699002	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tccgagaccggccgggcccaGagctacgcacagcagctggg	15	15	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:150699002G>C	uc003wif.2	+	13	1892	c.1596G>C	c.(1594-1596)CAG>CAC	p.Q532H	NOS3_uc011kuy.1_Missense_Mutation_p.Q326H|NOS3_uc011kuz.1_Missense_Mutation_p.Q532H|NOS3_uc011kva.1_Missense_Mutation_p.Q532H|NOS3_uc011kvb.1_Missense_Mutation_p.Q532H	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	532	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GCCGGGCCCAGAGCTACGCAC	0.647													0	0	0	0.006122	0	19	39										C	150699002	G	C	150699002	3	2	81	1	0	0	0	0	1	0	0	0	10544	933	33	1	1642	1	NOS3	7	150699002	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1546277	150699002	8439661	95	24239										
MLL3	58508	broad.mit.edu	37	chr7	151845284	151845288	+	Frame_Shift_Del	DEL	GAAGA	GAAGA	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctggcttcatagcccacaggGaagagtgctttaggagaatg							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			GAAGA	-	GAAGA	GAAGA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:151845284_151845288delGAAGA	uc003wla.2	-	52	13943_13947	c.13724_13728delTCTTC	c.(13723-13728)CTCTTCfs	p.L4575fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.L3693fs|MLL3_uc003wkx.2_Frame_Shift_Del_p.L733fs|MLL3_uc003wky.2_Frame_Shift_Del_p.L2139fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4575_4576	FYR N-terminal.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGCCCACAGGGAAGAGTGCTTTAGG	0.566			N		medulloblastoma													16	41	---	---								-	151845288	GAAGA	-	151845284	7	5	81	1	0	1	0	1	0	0	0	0	9622	1165	41	0	1039	0	MLL3	7	151845284	Frame_Shift_Del	DEL	GAAGA	TCGA-FD-A3SM-01A-11D-A22Z-08	1146282	151845284	7293379	96	24240										
LGI3	203190	broad.mit.edu	37	chr8	22005745	22005745	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aagctgggggccaggagtagCtgggcgtccccagcaggcat	17	11	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:22005745C>A	uc003xav.2	-	8	1864	c.1575G>T	c.(1573-1575)CAG>CAT	p.Q525H	LGI3_uc010ltu.2_Missense_Mutation_p.Q501H	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	525	EAR 7.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CCAGGAGTAGCTGGGCGTCCC	0.607													1	0	7.11191e-15	0.002836	7.47266e-15	34	39										A	22005745	C	A	22005745	3	1	81	1	0	0	0	0	1	0	0	0	8753	796	28	4	75	4	LGI3	8	22005745	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		22005745	124358277	97	24241										
GSR	2936	broad.mit.edu	37	chr8	30557646	30557646	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	catcgctggttattcctaagCtggcacctatgtagaaaaag	9	9	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:30557646C>T	uc003xih.1	-	6	738	c.647G>A	c.(646-648)AGC>AAC	p.S216N		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	216					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TATTCCTAAGCTGGCACCTAT	0.428													0	0	0	0.00333	0	24	25										T	30557646	C	T	30557646	3	4	81	1	0	0	0	0	1	0	0	0	6828	797	28	2	953	2	GSR	8	30557646	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8551901	30557646	115806376	98	24242										
ADAM32	203102	broad.mit.edu	37	chr8	39044508	39044508	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agtctgggaatatcatatgaCgacccaaagaaatgtcaatg	9	7	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:39044508C>T	uc003xmt.3	+	11	1241	c.996C>T	c.(994-996)GAC>GAT	p.D332D	ADAM32_uc011lch.1_Intron|ADAM32_uc003xmu.3_Intron	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	332	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TATCATATGACGACCCAAAGA	0.348													0	0	0	0.00361	0	103	32										T	39044508	C	T	39044508	2	4	81	1	0	0	0	0	0	0	0	1	249	535	19	2		2	ADAM32	8	39044508	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8486862	39044508	107319514	99	24243										
RDH10	157506	broad.mit.edu	37	chr8	74235043	74235043	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tacatcgtgaccttcatgaaGaggtaactgggaggggttcc	13	8	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:74235043G>C	uc003xzi.2	+	5	1160	c.900G>C	c.(898-900)AAG>AAC	p.K300N	RDH10_uc003xzj.2_Missense_Mutation_p.K135N|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	300					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			CCTTCATGAAGAGGTAACTGG	0.512													0	0	0	0.002836	0	31	51										C	74235043	G	C	74235043	3	2	81	1	0	0	0	0	1	0	0	0	13189	933	33	1	918	1	RDH10	8	74235043	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	35190535	74235043	72128979	100	24244										
ZFAND1	79752	broad.mit.edu	37	chr8	82626198	82626198	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcatgcatctttaatttcatCaatgcaacctttgcagctgt	6	10	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:82626198C>T	uc003ycj.1	-	6	449	c.435G>A	c.(433-435)TTG>TTA	p.L145L	ZFAND1_uc010lzx.1_Silent_p.L145L|ZFAND1_uc003yck.1_Silent_p.L38L	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	145							zinc ion binding			ovary(1)	1						TTAATTTCATCAATGCAACCT	0.313													0	0	0	0.007413	0	19	27										T	82626198	C	T	82626198	2	4	81	1	0	0	0	0	0	0	0	1	17623	825	29	1		1	ZFAND1	8	82626198	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8391155	82626198	63737824	101	24245										
RAD54B	25788	broad.mit.edu	37	chr8	95392433	95392433	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	attaagtgagatcctccaatGaggttaagtcctacaccacc	7	11	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:95392433G>T	uc003ygk.2	-	12	2285	c.2187C>A	c.(2185-2187)CTC>CTA	p.L729L	RAD54B_uc010may.1_Silent_p.L536L	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ATCCTCCAATGAGGTTAAGTC	0.318								Direct_reversal_of_damage|Homologous_recombination					1	0	1.49906e-05	0.00245	1.52536e-05	14	19										T	95392433	G	T	95392433	2	4	81	1	0	0	0	0	0	0	0	1	12992	1277	45	3		3	RAD54B	8	95392433	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	12766235	95392433	50971589	102	24246										
RAD54B	25788	broad.mit.edu	37	chr8	95392461	95392461	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtcctacaccaccagcttttGaacttaacaaaaaaataaaa	3	10	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:95392461G>C	uc003ygk.2	-	12	2257	c.2159C>G	c.(2158-2160)TCA>TGA	p.S720*	RAD54B_uc010may.1_Nonsense_Mutation_p.S527*	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ACCAGCTTTTGAACTTAACAA	0.368								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.008291	0	11	24										C	95392461	G	C	95392461	4	2	81	1	0	0	0	0	0	1	0	0	12992	1294	45	1	589	1	RAD54B	8	95392461	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	28	95392461	50971561	103	24247										
UBR5	51366	broad.mit.edu	37	chr8	103357737	103357737	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	taatgacacttgggtgggcaGaatgaatgtcggcatcaagg	14	6	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:103357737G>A	uc003ykr.1	-	8	806	c.773C>T	c.(772-774)TCT>TTT	p.S258F	UBR5_uc003yks.1_Missense_Mutation_p.S258F	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	258				S -> Y (in Ref. 2; AAF88143).	cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGGGTGGGCAGAATGAATGTC	0.413													0	0	0	0.006122	0	17	31										A	103357737	G	A	103357737	3	1	81	1	0	0	0	0	1	0	0	0	16902	942	33	1	7834	1	UBR5	8	103357737	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	7965276	103357737	43006285	104	24248										
CSMD3	114788	broad.mit.edu	37	chr8	113529420	113529420	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttcgagtcccattcatgggGacccctgggtcacgacacgc	11	14	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:113529420G>A	uc003ynu.2	-	28	4758	c.4599C>T	c.(4597-4599)GTC>GTT	p.V1533V	CSMD3_uc003yns.2_Silent_p.V805V|CSMD3_uc003ynt.2_Silent_p.V1493V|CSMD3_uc011lhx.1_Silent_p.V1429V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1533	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTCATGGGGACCCCTGGGT	0.423										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.007413	0	17	30										A	113529420	G	A	113529420	2	1	81	1	0	0	0	0	0	0	0	1	3946	1161	41	1		1	CSMD3	8	113529420	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	10171683	113529420	32834602	105	24249										
HAS2	3037	broad.mit.edu	37	chr8	122626714	122626714	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gagagacatgaagaccatgaCgatatttcctctaaggcagc	10	9	1	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:122626714C>G	uc003yph.2	-	4	1832	c.1294G>C	c.(1294-1296)GTC>CTC	p.V432L		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	432	Helical; Name=5; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AAGACCATGACGATATTTCCT	0.428													0	0	0	0.004482	0	9	206										G	122626714	C	G	122626714	3	3	81	1	0	0	0	0	1	0	0	0	6962	536	19	4	368	4	HAS2	8	122626714	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	9097294	122626714	23737308	106	24250										
DGAT1	8694	broad.mit.edu	37	chr8	145540687	145540687	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gccccccagagcactgacctCgtggaagaaggccgaggcca	13	15	0	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:145540687C>G	uc003zbv.3	-	15	1514	c.1246G>C	c.(1246-1248)GAG>CAG	p.E416Q	DGAT1_uc010mfv.2_Missense_Mutation_p.R250P	NM_012079	NP_036211	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	416	Lumenal (Potential).				triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GCACTGACCTCGTGGAAGAAG	0.647													0	0	0	0.006122	0	19	37										G	145540687	C	G	145540687	3	3	81	1	0	0	0	0	1	0	0	0	4457	893	31	1	232	1	DGAT1	8	145540687	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	22913973	145540687	823335	107	24251										
TTC16	158248	broad.mit.edu	37	chr9	130482603	130482603	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctcacgctcatcaccaacGagctgaagcaggacaccacc	8	17	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr9:130482603G>T	uc004brq.1	+	6	653	c.586G>T	c.(586-588)GAG>TAG	p.E196*	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Nonsense_Mutation_p.E183*|TTC16_uc004brr.1_Nonsense_Mutation_p.E141*|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	196							binding				0						CATCACCAACGAGCTGAAGCA	0.622													1	0	4.18559e-23	0.00361	4.46257e-23	50	37										T	130482603	G	T	130482603	4	4	81	1	0	0	0	0	0	1	0	0	16680	1059	37	3	608	3	TTC16	9	130482603	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		130482603	10730828	108	24252										
TSC1	7248	broad.mit.edu	37	chr9	135781236	135781236	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gggagtgaagatactggtctCcaaagaagtctggcattccc	12	9	2	3	rs118203570		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr9:135781236C>A	uc004cca.2	-	15	1963	c.1729G>T	c.(1729-1731)GAG>TAG	p.E577*	TSC1_uc004ccb.3_Nonsense_Mutation_p.E576*|TSC1_uc011mcq.1_Nonsense_Mutation_p.E526*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	577			E -> D.		activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		ATACTGGTCTCCAAAGAAGTC	0.547			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				1	0	4.26978e-12	0.00333	4.43812e-12	22	21										A	135781236	C	A	135781236	4	1	81	1	0	0	0	0	0	1	0	0	16602	864	30	3	1801	3	TSC1	9	135781236	Nonsense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	5298633	135781236	5432195	109	24253										
GPSM1	26086	broad.mit.edu	37	chr9	139250815	139250815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccagccctcgatgacggcctCgccccagaccgaggaattct	10	17	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr9:139250815C>T	uc004chd.2	+	13	1854	c.1634C>T	c.(1633-1635)TCG>TTG	p.S545L	GPSM1_uc011mdu.1_Missense_Mutation_p.S36L|GPSM1_uc004che.2_Missense_Mutation_p.S36L	NM_001145638	NP_001139110	Q86YR5	GPSM1_HUMAN	G-protein signaling modulator 1 (AGS3-like, C.	545					cell differentiation|nervous system development|signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|plasma membrane	binding|GTPase activator activity				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.39e-06)|Epithelial(140;3.24e-06)		ATGACGGCCTCGCCCCAGACC	0.721													0	0	0	0.004482	0	9	8										T	139250815	C	T	139250815	3	4	81	1	0	0	0	0	1	0	0	0	6734	893	31	1	1851	1	GPSM1	9	139250815	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	3469579	139250815	1962616	110	24254										
GAD2	2572	broad.mit.edu	37	chr10	26558051	26558051	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttctttttccttccagaggGaaaatgattccatctgatct	6	9	3	3	rs149629039	byFrequency	TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:26558051G>T	uc001isp.2	+	9	1427	c.924G>T	c.(922-924)GGG>GGT	p.G308G	GAD2_uc001isq.2_Silent_p.G308G	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	308					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CTTCCAGAGGGAAAATGATTC	0.403													1	0	9.16793e-09	0.00499	9.42801e-09	17	42										T	26558051	G	T	26558051	2	4	81	1	0	0	0	0	0	0	0	1	6180	1161	41	3		3	GAD2	10	26558051	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		26558051	108976696	111	24255										
ARMC4	55130	broad.mit.edu	37	chr10	28196616	28196616	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcatttttgatgcatggacaGagtgcccatgctgcgctggc	13	10	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:28196616G>C	uc009xky.2	-	17	2684	c.2586C>G	c.(2584-2586)CTC>CTG	p.L862L	ARMC4_uc010qds.1_Silent_p.L387L|ARMC4_uc010qdt.1_Silent_p.L554L|ARMC4_uc001itz.2_Silent_p.L862L	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	862	ARM 6.						binding			ovary(4)|skin(2)	6						TGCATGGACAGAGTGCCCATG	0.448													0	0	0	0.001882	0	21	37										C	28196616	G	C	28196616	2	2	81	1	0	0	0	0	0	0	0	1	953	929	33	1		1	ARMC4	10	28196616	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1638565	28196616	107338131	112	24256										
ANK3	288	broad.mit.edu	37	chr10	61835134	61835134	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gagtctggaagtttctttaaTgctggttctggcaaaacatt	10	6	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:61835134T>A	uc001jky.2	-	37	5697	c.5505A>T	c.(5503-5505)GCA>GCT	p.A1835A	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1835	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTTCTTTAATGCTGGTTCTG	0.413													0	0	0	0.00361	0	53	150										A	61835134	T	A	61835134	2	1	81	1	0	0	0	0	0	0	0	1	622	1451	51	5		5	ANK3	10	61835134	Silent	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	33638518	61835134	73699613	113	24257										
CDH23	64072	broad.mit.edu	37	chr10	73572328	73572328	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acctaccggagaacctgagtGagatcgccgacctgtggaac	12	12	0	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:73572328G>C	uc001jrx.3	+	65	9849	c.9472G>C	c.(9472-9474)GAG>CAG	p.E3158Q	CDH23_uc001jsg.3_Missense_Mutation_p.E918Q|CDH23_uc001jsh.3_Missense_Mutation_p.E918Q|CDH23_uc001jsi.3_Missense_Mutation_p.E918Q|CDH23_uc001jsj.3_Missense_Mutation_p.E55Q|CDH23_uc010qjr.1_Missense_Mutation_p.E55Q	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3158	Cytoplasmic (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GAACCTGAGTGAGATCGCCGA	0.642													0	0	0	0.00623	0	39	72										C	73572328	G	C	73572328	3	2	81	1	0	0	0	0	1	0	0	0	3108	1291	45	1	10154	1	CDH23	10	73572328	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	11737194	73572328	61962419	114	24258										
ENTPD7	57089	broad.mit.edu	37	chr10	101460767	101460767	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttggtcggtactaactcagaGattcaagaatggcctctttt	9	8	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:101460767G>A	uc001kqa.3	+	11	1551	c.1373G>A	c.(1372-1374)AGA>AAA	p.R458K	ENTPD7_uc009xwl.2_Missense_Mutation_p.R460K	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	458	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CTAACTCAGAGATTCAAGAAT	0.443													0	0	0	0.00361	0	86	168										A	101460767	G	A	101460767	3	1	81	1	0	0	0	0	1	0	0	0	5144	942	33	1	1411	1	ENTPD7	10	101460767	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	27888439	101460767	34073980	115	24259										
DCLRE1A	9937	broad.mit.edu	37	chr10	115609492	115609492	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	taaactcttaactaacggaaGagaaacttgattgtaaacag	7	6	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:115609492G>A	uc001law.2	-	2	2290	c.1372C>T	c.(1372-1374)CTT>TTT	p.L458F		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	458	Nuclear focus formation.				cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		ACTAACGGAAGAGAAACTTGA	0.343								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.007413	0	19	38										A	115609492	G	A	115609492	3	1	81	1	0	0	0	0	1	0	0	0	4294	942	33	1	1782	1	DCLRE1A	10	115609492	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	14148725	115609492	19925255	116	24260										
DCLRE1A	9937	broad.mit.edu	37	chr10	115610376	115610376	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgtaatgaaaaggaatggttGaggtacacagaagaccatca	11	5	1	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:115610376G>C	uc001law.2	-	2	1406	c.488C>G	c.(487-489)TCA>TGA	p.S163*		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	163	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		AGGAATGGTTGAGGTACACAG	0.408								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.008291	0	9	20										C	115610376	G	C	115610376	4	2	81	1	0	0	0	0	0	1	0	0	4294	1294	45	1	2666	1	DCLRE1A	10	115610376	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	884	115610376	19924371	117	24261										
STK32C	282974	broad.mit.edu	37	chr10	134059433	134059433	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctgcccttcccaatggcccGaaggatctggaagtggtcga	13	12	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:134059433G>A	uc001lle.1	-	2	429	c.289C>T	c.(289-291)CGG>TGG	p.R97W	STK32C_uc001lld.1_5'UTR|STK32C_uc010quu.1_Missense_Mutation_p.R110W|STK32C_uc009ybc.1_5'UTR|STK32C_uc009ybd.1_5'UTR|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	97	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCAATGGCCCGAAGGATCTGG	0.627													0	0	0	0.00333	0	22	58										A	134059433	G	A	134059433	3	1	81	1	0	0	0	0	1	0	0	0	15298	1057	37	1	1215	1	STK32C	10	134059433	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	18449057	134059433	1475314	118	24262										
B4GALNT4	338707	broad.mit.edu	37	chr11	376347	376347	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gccttcctcttcctcaacccGgacggtgagtgtccgcagcg	11	16	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:376347G>A	uc001lpb.2	+	13	1302	c.1293G>A	c.(1291-1293)CCG>CCA	p.P431P		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	431	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCCTCAACCCGGACGGTGAGT	0.617													0	0	0	0.001368	0	12	46										A	376347	G	A	376347	2	1	81	1	0	0	0	0	0	0	0	1	1269	1103	39	2		2	B4GALNT4	11	376347	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		376347	134630169	119	24263										
OR52A4	390053	broad.mit.edu	37	chr11	5142584	5142584	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acaatgctggtgctaagtgaAatgtctgtggctcctaacgt	11	8	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:5142584A>T	uc001lzz.1	-	1	225	c.225T>A	c.(223-225)ATT>ATA	p.I75I	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGCTAAGTGAAATGTCTGTGG	0.428													0	0	0	0.00499	0	18	53										T	5142584	A	T	5142584	2	4	81	1	0	0	0	0	0	0	0	1	11109	10	1	5		5	OR52A4	11	5142584	Silent	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	4766237	5142584	129863932	120	24264										
DNHD1	144132	broad.mit.edu	37	chr11	6592276	6592276	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctgttgcagcagctgaagGgcgcacccccgtgcccctcc	12	18	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:6592276G>A	uc001mdw.3	+	42	14098	c.13534G>A	c.(13534-13536)GGC>AGC	p.G4512S	DNHD1_uc001mea.3_Missense_Mutation_p.G781S|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.G780S|DNHD1_uc010rao.1_Missense_Mutation_p.G770S|DNHD1_uc009yfg.2_Missense_Mutation_p.G137S	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4512					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCAGCTGAAGGGCGCACCCCC	0.682													0	0	0	0.003163	0	14	33										A	6592276	G	A	6592276	3	1	81	1	0	0	0	0	1	0	0	0	4668	1232	43	2	13701	2	DNHD1	11	6592276	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1449692	6592276	128414240	121	24265										
DGKZ	8525	broad.mit.edu	37	chr11	46398102	46398102	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gccagccgcttctacaggatCgaccgagcccaggtgagcga	13	14	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:46398102C>T	uc001ncn.1	+	25	2879	c.2754C>T	c.(2752-2754)ATC>ATT	p.I918I	DGKZ_uc001nch.1_Silent_p.I746I|DGKZ_uc010rgq.1_Silent_p.I673I|DGKZ_uc001ncj.1_Silent_p.I696I|DGKZ_uc010rgr.1_Silent_p.I695I|DGKZ_uc001nck.1_Silent_p.I508I|DGKZ_uc001ncl.2_Silent_p.I730I|DGKZ_uc001ncm.2_Silent_p.I729I|DGKZ_uc009yky.1_Silent_p.I730I|DGKZ_uc010rgs.1_Silent_p.I707I	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	918					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding	p.I746I(1)		pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TCTACAGGATCGACCGAGCCC	0.672													0	0	0	0.002852	0	42	89										T	46398102	C	T	46398102	2	4	81	1	0	0	0	0	0	0	0	1	4474	874	31	1		1	DGKZ	11	46398102	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	39805826	46398102	88608414	122	24266										
OR4P4	81300	broad.mit.edu	37	chr11	55406520	55406520	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atcagagcatactctgcagaGagacgcagcaaagctcttgc	10	11	3	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:55406520G>C	uc010rij.1	+	1	687	c.687G>C	c.(685-687)GAG>GAC	p.E229D		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ACTCTGCAGAGAGACGCAGCA	0.383													0	0	0	0.004656	0	26	56										C	55406520	G	C	55406520	3	2	81	1	0	0	0	0	1	0	0	0	11080	933	33	1	689	1	OR4P4	11	55406520	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	9008418	55406520	79599996	123	24267										
OR5F1	338674	broad.mit.edu	37	chr11	55761768	55761768	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cattaacccaaagaggatgcAttcggttgtcgccagggaga	12	9	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:55761768A>G	uc010riv.1	-	1	334	c.334T>C	c.(334-336)TGC>CGC	p.C112R		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AAGAGGATGCATTCGGTTGTC	0.473													0	0	0	0.007835	0	42	103										G	55761768	A	G	55761768	3	3	81	1	0	0	0	0	1	0	0	0	11158	217	8	5	613	5	OR5F1	11	55761768	Missense_Mutation	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	355248	55761768	79244748	124	24268										
PLCB3	5331	broad.mit.edu	37	chr11	64032574	64032574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cagcacctccctcagcagccCaggtaaggagtggcctgggt	13	14	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:64032574C>T	uc001nzb.2	+	23	2804	c.2804C>T	c.(2803-2805)CCA>CTA	p.P935L	PLCB3_uc009ypg.1_Missense_Mutation_p.P935L|PLCB3_uc009yph.1_Missense_Mutation_p.P868L|PLCB3_uc009ypi.2_Missense_Mutation_p.P935L	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	935					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CTCAGCAGCCCAGGTAAGGAG	0.721													0	0	0	0.009096	0	3	4										T	64032574	C	T	64032574	3	4	81	1	0	0	0	0	1	0	0	0	12029	594	21	2	2894	2	PLCB3	11	64032574	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8270806	64032574	70973942	125	24269										
PLCB3	5331	broad.mit.edu	37	chr11	64033997	64033997	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gagattaaccgtcggcacatCactgagtcagtcaactccat	8	12	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:64033997C>T	uc001nzb.2	+	29	3387	c.3387C>T	c.(3385-3387)ATC>ATT	p.I1129I	PLCB3_uc009ypg.1_Silent_p.I1129I|PLCB3_uc009yph.1_Silent_p.I1062I|PLCB3_uc009ypi.2_Silent_p.I1129I	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1129					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GTCGGCACATCACTGAGTCAG	0.632													0	0	0	0.002096	0	28	57										T	64033997	C	T	64033997	2	4	81	1	0	0	0	0	0	0	0	1	12029	816	29	1		1	PLCB3	11	64033997	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1423	64033997	70972519	126	24270										
SF3B2	10992	broad.mit.edu	37	chr11	65831159	65831159	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggaatggagacccctgaactCattgagctgaggaagaagaa	13	7	1	6			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:65831159C>G	uc001ogy.1	+	19	2329	c.2289C>G	c.(2287-2289)CTC>CTG	p.L763L		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	763					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						CCCCTGAACTCATTGAGCTGA	0.537													0	0	0	0.003163	0	13	27										G	65831159	C	G	65831159	2	3	81	1	0	0	0	0	0	0	0	1	14151	813	29	1		1	SF3B2	11	65831159	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1797162	65831159	69175357	127	24271										
GSTP1	2950	broad.mit.edu	37	chr11	67353985	67353985	+	Silent	SNP	C	C	G													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctcagtgcccggcccaagctCaaggccttcctggcctcccc							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:67353985C>G	uc001omf.2	+	7	819	c.570C>G	c.(568-570)CTC>CTG	p.L190L	GSTP1_uc001omg.1_Silent_p.L171L	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	190	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	GGCCCAAGCTCAAGGCCTTCC	0.627													0	0	0	0.004007	0	17	28										G	67353985	C	G	67353985	2	3	81	1	0	0	0	0	0	0	0	1	6844	813	29	1		1	GSTP1	11	67353985	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1522826	67353985	67652531	128	24272	123	2								
GSTP1	2950	broad.mit.edu	37	chr11	67353995	67353995	+	Silent	SNP	C	C	T													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggcccaagctcaaggccttcCtggcctcccctgagtacgtg							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:67353995C>T	uc001omf.2	+	7	829	c.580C>T	c.(580-582)CTG>TTG	p.L194L	GSTP1_uc001omg.1_Silent_p.L175L	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	194	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	CAAGGCCTTCCTGGCCTCCCC	0.622													0	0	0	0.004007	0	16	23										T	67353995	C	T	67353995	2	4	81	1	0	0	0	0	0	0	0	1	6844	680	24	2		2	GSTP1	11	67353995	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	10	67353995	67652521	129	24273	123	2								
PDE2A	5138	broad.mit.edu	37	chr11	72292403	72292403	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggagatgcagccactcactcGaggtagttggtgagctccag	14	10	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:72292403G>A	uc010rrc.1	-	23	2286	c.2043C>T	c.(2041-2043)CTC>CTT	p.L681L	PDE2A_uc001oso.2_Silent_p.L660L|PDE2A_uc010rra.1_Silent_p.L674L|PDE2A_uc001osn.2_Silent_p.L425L|PDE2A_uc010rrb.1_Silent_p.L672L|PDE2A_uc010rrd.1_Silent_p.L566L	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	681	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CCACTCACTCGAGGTAGTTGG	0.532													0	0	0	0.006122	0	16	30										A	72292403	G	A	72292403	2	1	81	1	0	0	0	0	0	0	0	1	11636	1045	37	1		1	PDE2A	11	72292403	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	4938408	72292403	62714113	130	24274										
POLD3	10714	broad.mit.edu	37	chr11	74303737	74303737	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttatctggaaaatatagacGagttcgtcacggaccaaaac	8	8	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:74303737G>A	uc001ovf.1	+	1	109	c.34G>A	c.(34-36)GAG>AAG	p.E12K	POLD3_uc009yua.1_5'UTR	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	12					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					AAATATAGACGAGTTCGTCAC	0.642													0	0	0	0.003163	0	15	18										A	74303737	G	A	74303737	3	1	81	1	0	0	0	0	1	0	0	0	12192	1059	37	1	36	1	POLD3	11	74303737	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2011334	74303737	60702779	131	24275										
FAT3	120114	broad.mit.edu	37	chr11	92531056	92531056	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cctaggcatcatcaccatttGcaaagaaccagacatgacga	7	12	2	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:92531056G>A	uc001pdj.3	+	9	4894	c.4877G>A	c.(4876-4878)TGC>TAC	p.C1626Y		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1626	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATCACCATTTGCAAAGAACCA	0.453										TCGA Ovarian(4;0.039)			0	0	0	0.00361	0	47	73										A	92531056	G	A	92531056	3	1	81	1	0	0	0	0	1	0	0	0	5691	1319	46	2	4911	2	FAT3	11	92531056	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	18227319	92531056	42475460	132	24276										
SIK3	23387	broad.mit.edu	37	chr11	116741051	116741052	+	Nonsense_Mutation	DNP	GC	GC	AA													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccagatgtcacattacctctGcacagcttcctggtctggct							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:116741051_116741052GC>AA	uc001ppy.2	-	14	1665_1666	c.1629_1630GC>TT	c.(1627-1632)GTGCAG>GTTTAG	p.Q544*	SIK3_uc001ppz.2_Nonsense_Mutation_p.Q443*|SIK3_uc001pqa.2_Nonsense_Mutation_p.Q496*|SIK3_uc001ppx.2_5'Flank	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	544						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						CATTACCTCTGCACAGCTTCCT	0.594											OREG0003489	type=REGULATORY REGION|Gene=BC063887|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004672	0	12	27										AA	116741052	GC	AA	116741051	4	1	81	1	0	0	0	0	0	1	0	0	14319	1328	46	2	2201	2	SIK3	11	116741051	Nonsense_Mutation	DNP	GC	TCGA-FD-A3SM-01A-11D-A22Z-08	24209995	116741051	18265465	133	24277										
OR10G4	390264	broad.mit.edu	37	chr11	123886665	123886665	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tacttggccatcagttacccGctcaggtacaccagcatgat	8	13	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:123886665G>A	uc010sac.1	+	1	384	c.384G>A	c.(382-384)CCG>CCA	p.P128P		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TCAGTTACCCGCTCAGGTACA	0.557													0	0	0	0.00361	0	50	125										A	123886665	G	A	123886665	2	1	81	1	0	0	0	0	0	0	0	1	10901	1074	38	2		2	OR10G4	11	123886665	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	7145614	123886665	11119851	134	24278										
GLB1L3	112937	broad.mit.edu	37	chr11	134181051	134181051	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cccgctgtgggacgccctatCctacttaaatgaggtgcgtg	12	12	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:134181051C>G	uc009zdf.2	+	13	1634	c.1274C>G	c.(1273-1275)TCC>TGC	p.S425C	GLB1L3_uc010scu.1_3'UTR|GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	425					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GACGCCCTATCCTACTTAAAT	0.582													0	0	0	0.00361	0	114	196										G	134181051	C	G	134181051	3	3	81	1	0	0	0	0	1	0	0	0	6430	855	30	1	1324	1	GLB1L3	11	134181051	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	10294386	134181051	825465	135	24279										
C12orf53	196500	broad.mit.edu	37	chr12	6806635	6806635	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tggggtcccctccatcctctCgagacacggtgggaccccac	11	17	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:6806635C>T	uc001qqf.1	-	3	417	c.341G>A	c.(340-342)CGA>CAA	p.R114Q	C12orf53_uc001qqg.1_Missense_Mutation_p.R114Q	NM_153685	NP_710152	Q8IYJ0	CL053_HUMAN	hypothetical protein LOC196500 precursor	114	Extracellular (Potential).					integral to membrane					0						TCCATCCTCTCGAGACACGGT	0.632													0	0	0	0.006122	0	16	24										T	6806635	C	T	6806635	3	4	81	1	0	0	0	0	1	0	0	0	1698	884	31	1	523	1	C12orf53	12	6806635	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		6806635	127045260	136	24280										
ERGIC2	51290	broad.mit.edu	37	chr12	29498396	29498396	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cctttctgtcacagaaaactGatgggtgtctgctgatattt	9	8	3	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:29498396G>A	uc001riv.2	-	11	938	c.805C>T	c.(805-807)CAG>TAG	p.Q269*	ERGIC2_uc001riw.2_RNA	NM_016570	NP_057654	Q96RQ1	ERGI2_HUMAN	PTX1 protein	269	Lumenal (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				ovary(1)	1	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)	ACAGAAAACTGATGGGTGTCT	0.303													0	0	0	0.002852	0	42	91										A	29498396	G	A	29498396	4	1	81	1	0	0	0	0	0	1	0	0	5224	1299	45	1	344	1	ERGIC2	12	29498396	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	22691761	29498396	104353499	137	24281										
IPO8	10526	broad.mit.edu	37	chr12	30802107	30802107	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cctttgcactgaagaatgatGacttccagaagtttagctgc	9	9	0	5			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:30802107G>A	uc001rjd.2	-	20	2402	c.2232C>T	c.(2230-2232)GTC>GTT	p.V744V	IPO8_uc001rje.1_Silent_p.V233V|IPO8_uc010sjt.1_Silent_p.V539V	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	744					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAAGAATGATGACTTCCAGAA	0.428													0	0	0	0.00623	0	37	77										A	30802107	G	A	30802107	2	1	81	1	0	0	0	0	0	0	0	1	7798	1277	45	1		1	IPO8	12	30802107	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1303711	30802107	103049788	138	24282										
DENND5B	160518	broad.mit.edu	37	chr12	31540716	31540716	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatccactgtgggagcaggcGatccctacagacccaaacag	10	13	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:31540716G>T	uc001rki.1	-	21	3832	c.3646C>A	c.(3646-3648)CGC>AGC	p.R1216S	DENND5B_uc001rkh.1_Missense_Mutation_p.R1251S|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1216	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GGGAGCAGGCGATCCCTACAG	0.527													1	0	2.31682e-05	0.003163	2.34923e-05	15	31										T	31540716	G	T	31540716	3	4	81	1	0	0	0	0	1	0	0	0	4437	1058	37	3	182	3	DENND5B	12	31540716	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	738609	31540716	102311179	139	24283										
MLL2	8085	broad.mit.edu	37	chr12	49427126	49427126	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tggttgaggggacagctgctGgaccaggaggccttggtggc	19	8	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:49427126G>A	uc001rta.3	-	39	11362	c.11362C>T	c.(11362-11364)CAG>TAG	p.Q3788*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3788	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GACAGCTGCTGGACCAGGAGG	0.667			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.000602	0	5	6										A	49427126	G	A	49427126	4	1	81	1	0	0	0	0	0	1	0	0	9621	1357	47	2	5315	2	MLL2	12	49427126	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	17886410	49427126	84424769	140	24284										
FMNL3	91010	broad.mit.edu	37	chr12	50050233	50050233	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggatgatttcgtgacctcctCgcaccaaacacacagctgcc	8	15	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:50050233C>T	uc001ruv.1	-	9	1073	c.839G>A	c.(838-840)CGA>CAA	p.R280Q	FMNL3_uc001ruw.1_Missense_Mutation_p.R229Q|FMNL3_uc001ruu.1_Missense_Mutation_p.R130Q	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	280	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						GTGACCTCCTCGCACCAAACA	0.512													0	0	0	0.008291	0	10	32										T	50050233	C	T	50050233	3	4	81	1	0	0	0	0	1	0	0	0	5953	884	31	1	2316	1	FMNL3	12	50050233	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	623107	50050233	83801662	141	24285										
MYF5	4617	broad.mit.edu	37	chr12	81111214	81111214	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctgcccaaggtggagatcctCaggaatgccatccgctacat	10	13	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:81111214C>G	uc001szg.2	+	1	507	c.372C>G	c.(370-372)CTC>CTG	p.L124L		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	124	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TGGAGATCCTCAGGAATGCCA	0.597													0	0	0	0.00361	0	52	81										G	81111214	C	G	81111214	2	3	81	1	0	0	0	0	0	0	0	1	10027	813	29	1		1	MYF5	12	81111214	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	31060981	81111214	52740681	142	24286										
SLC17A8	246213	broad.mit.edu	37	chr12	100751235	100751235	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cctgggaaggaaggagtgaaGaacgccgtgggagattcttt	16	6	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:100751235G>C	uc010svi.1	+	1	379	c.66G>C	c.(64-66)AAG>AAC	p.K22N	SLC17A8_uc009ztx.2_Missense_Mutation_p.K22N	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	22	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						AAGGAGTGAAGAACGCCGTGG	0.413													0	0	0	0.003755	0	36	88										C	100751235	G	C	100751235	3	2	81	1	0	0	0	0	1	0	0	0	14423	933	33	1	68	1	SLC17A8	12	100751235	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	19640021	100751235	33100660	143	24287										
C12orf48	55010	broad.mit.edu	37	chr12	102576369	102576369	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcgataaaacccctaagagaAcgcatctgtgtgtcaatgca	8	10	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:102576369A>T	uc001tjf.2	+	9	1339	c.1227A>T	c.(1225-1227)GAA>GAT	p.E409D	C12orf48_uc001tjg.2_Missense_Mutation_p.E328D|C12orf48_uc010swa.1_Missense_Mutation_p.E486D|C12orf48_uc001tjh.2_Missense_Mutation_p.E328D|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.E124D|C12orf48_uc001tjk.2_Missense_Mutation_p.E288D|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	409					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						CCCTAAGAGAACGCATCTGTG	0.264													0	0	0	0.001368	0	12	16										T	102576369	A	T	102576369	3	4	81	1	0	0	0	0	1	0	0	0	1692	40	2	5	1010	5	C12orf48	12	102576369	Missense_Mutation	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	1825134	102576369	31275526	144	24288										
HMGB1	3146	broad.mit.edu	37	chr13	31037474	31037474	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atcttcaaattttcctttctCtttagcagacatggtctaca	4	10	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr13:31037474C>G	uc001usw.2	-	3	350	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	HMGB1_uc001usz.2_Missense_Mutation_p.E56Q|HMGB1_uc001usv.2_Missense_Mutation_p.E56Q|HMGB1_uc001usx.2_Missense_Mutation_p.E56Q|HMGB1_uc001usy.2_Intron|HMGB1_uc001uta.1_Missense_Mutation_p.E56Q	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	56	HMG box 1.				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		TTTCCTTTCTCTTTAGCAGAC	0.333													0	0	0	0.008361	0	31	36										G	31037474	C	G	31037474	3	3	81	1	0	0	0	0	1	0	0	0	7225	922	32	1	493	1	HMGB1	13	31037474	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		31037474	84132404	145	24289										
CAB39L	81617	broad.mit.edu	37	chr13	49957036	49957037	+	Frame_Shift_Ins	INS	-	-	T													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgatttactaaacaaaggcaINStttttttcatgtgtagaaat							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr13:49957036_49957037insT	uc001vcw.2	-	2	508_509	c.10_11insA	c.(10-12)ATGfs	p.M4fs	CAB39L_uc001vcx.2_Frame_Shift_Ins_p.M4fs|CAB39L_uc010adf.2_Frame_Shift_Ins_p.M1fs	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	4					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		AAACAAAGGCATTTTTTTCATG	0.287																		16	63	---	---								T	49957037	-	T	49957036	7	5	81	1	0	1	1	0	0	0	0	0	2526	217	8	0	1034	0	CAB39L	13	49957036	Frame_Shift_Ins	INS	-	TCGA-FD-A3SM-01A-11D-A22Z-08	18919562	49957036	65212842	146	24290										
IRS2	8660	broad.mit.edu	37	chr13	110435362	110435362	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cgcgggggcaacggcggataCggggaggaggcctcggggga	23	9	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr13:110435362C>T	uc001vqv.2	-	1	3553	c.3039G>A	c.(3037-3039)CCG>CCA	p.P1013P		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1013					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			acggcggATACGGGGAGGAGG	0.368													0	0	0	0.004672	0	3	2										T	110435362	C	T	110435362	2	4	81	1	0	0	0	0	0	0	0	1	7841	523	19	2		2	IRS2	13	110435362	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	60478326	110435362	4734516	147	24291										
TMEM55B	90809	broad.mit.edu	37	chr14	20929450	20929450	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cgccaccgtcgatgggctcaGacagcagcggggaacgctct	14	14	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:20929450G>A	uc001vxl.2	-	1	188	c.35C>T	c.(34-36)TCT>TTT	p.S12F	TMEM55B_uc001vxk.2_Missense_Mutation_p.S12F	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	12						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		GATGGGCTCAGACAGCAGCGG	0.672													0	0	0	0.009096	0	3	4										A	20929450	G	A	20929450	3	1	81	1	0	0	0	0	1	0	0	0	16179	942	33	1	847	1	TMEM55B	14	20929450	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		20929450	86420090	148	24292										
PRMT5	10419	broad.mit.edu	37	chr14	23397792	23397792	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgaactccctcttgaaacgcGgatggaagacaggcatgcag	12	10	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:23397792G>T	uc001whm.1	-	2	234	c.143C>A	c.(142-144)CCG>CAG	p.P48Q	PRMT5_uc001whl.1_Missense_Mutation_p.P31Q|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Intron|PRMT5_uc010tng.1_Missense_Mutation_p.P31Q|PRMT5_uc010tnh.1_Missense_Mutation_p.P48Q|PRMT5_uc001whn.1_Missense_Mutation_p.P31Q	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	48					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		CTTGAAACGCGGATGGAAGAC	0.537													1	0	3.01185e-09	0.003954	3.10831e-09	25	78										T	23397792	G	T	23397792	3	4	81	1	0	0	0	0	1	0	0	0	12539	1116	39	4	1834	4	PRMT5	14	23397792	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2468342	23397792	83951748	149	24293										
CPNE6	9362	broad.mit.edu	37	chr14	24543758	24543758	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aggatctgttcagcaagtctGaccctttcatggaaatctat	8	9	5	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:24543758G>C	uc001wll.2	+	6	616	c.517G>C	c.(517-519)GAC>CAC	p.D173H	CPNE6_uc010tnv.1_Missense_Mutation_p.D228H|CPNE6_uc001wlm.2_5'UTR|CPNE6_uc001wln.2_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	173	C2 2.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		CAGCAAGTCTGACCCTTTCAT	0.547													0	0	0	0.003954	0	23	64										C	24543758	G	C	24543758	3	2	81	1	0	0	0	0	1	0	0	0	3816	1290	45	1	535	1	CPNE6	14	24543758	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1145966	24543758	82805782	150	24294										
RALGAPA1	253959	broad.mit.edu	37	chr14	36121033	36121033	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcttgtccatttcataagatGaagcctctgtacttggtaaa	7	8	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:36121033G>A	uc001wti.2	-	30	4527	c.4136C>T	c.(4135-4137)TCA>TTA	p.S1379L	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.S1379L|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S1392L|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1426L	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1379	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TTCATAAGATGAAGCCTCTGT	0.274													0	0	0	0.004656	0	25	64										A	36121033	G	A	36121033	3	1	81	1	0	0	0	0	1	0	0	0	13013	1294	45	1	2171	1	RALGAPA1	14	36121033	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	11577275	36121033	71228507	151	24295										
FOXA1	3169	broad.mit.edu	37	chr14	38061263	38061263	+	Frame_Shift_Del	DEL	G	G	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tccgggtgcagcgtccagtaGgagcccttgcccggcttgtc							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:38061263delG	uc001wuf.2	-	2	1038	c.726delC	c.(724-726)TCCfs	p.S242fs	FOXA1_uc010tpz.1_Frame_Shift_Del_p.S209fs	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	242	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		GCGTCCAGTAGGAGCCCTTGC	0.587																		46	39	---	---								-	38061263	G	-	38061263	7	5	81	1	0	1	0	1	0	0	0	0	5989	987	35	0	696	0	FOXA1	14	38061263	Frame_Shift_Del	DEL	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1940230	38061263	69288277	152	24296										
FAM179B	23116	broad.mit.edu	37	chr14	45478126	45478126	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttttcttagatgcatagctCtcttaggtcccttcgtaata	6	9	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:45478126C>G	uc001wvv.2	+	6	3124	c.2915C>G	c.(2914-2916)TCT>TGT	p.S972C	FAM179B_uc001wvw.2_Missense_Mutation_p.S972C|FAM179B_uc010anc.2_Intron	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	972	Ser-rich.						binding			skin(2)|upper_aerodigestive_tract(1)	3						ATGCATAGCTCTCTTAGGTCC	0.338													0	0	0	0.008871	0	21	47										G	45478126	C	G	45478126	3	3	81	1	0	0	0	0	1	0	0	0	5506	913	32	1	2937	1	FAM179B	14	45478126	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	7416863	45478126	61871414	153	24297										
SIPA1L1	26037	broad.mit.edu	37	chr14	72125097	72125097	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acacaacatacaaagattatGaaattatgttccatgtttct	4	7	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:72125097G>A	uc001xms.2	+	6	2389	c.2041G>A	c.(2041-2043)GAA>AAA	p.E681K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E681K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E681K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E681K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.E156K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	681	Rap-GAP.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CAAAGATTATGAAATTATGTT	0.348													0	0	0	0.00333	0	20	35										A	72125097	G	A	72125097	3	1	81	1	0	0	0	0	1	0	0	0	14329	1291	45	1	2059	1	SIPA1L1	14	72125097	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	26646971	72125097	35224443	154	24298										
LTBP2	4053	broad.mit.edu	37	chr14	75017811	75017811	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acaccggcccagcagtcctcGaggcctgggtgctgctgggg	16	14	0	0	rs137854855		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:75017811G>A	uc001xqa.2	-	7	2029	c.1642C>T	c.(1642-1644)CGA>TGA	p.R548*		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	548					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGCAGTCCTCGAGGCCTGGGT	0.652													0	0	0	0.003163	0	15	39										A	75017811	G	A	75017811	4	1	81	1	0	0	0	0	0	1	0	0	9074	1066	37	1	3943	1	LTBP2	14	75017811	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2892714	75017811	32331729	155	24299										
TRIP11	9321	broad.mit.edu	37	chr14	92471361	92471361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatatcagagttatctgtttGaatgtcctgtctttcttcat	6	7	5	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:92471361G>C	uc001xzy.2	-	11	3747	c.2959C>G	c.(2959-2961)CAA>GAA	p.Q987E	TRIP11_uc010auf.1_Missense_Mutation_p.Q723E	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	987	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTATCTGTTTGAATGTCCTGT	0.333			T	PDGFRB	AML								0	0	0	0.003163	0	15	36										C	92471361	G	C	92471361	3	2	81	1	0	0	0	0	1	0	0	0	16552	1299	45	1	3024	1	TRIP11	14	92471361	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	17453550	92471361	14878179	156	24300										
SERPINA12	145264	broad.mit.edu	37	chr14	94964104	94964104	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	catgccaaaagccttacctcGaaagaaaatataatttgcaa	5	9	0	1	rs61757459	byFrequency	TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:94964104G>C	uc001ydj.2	-	3	1427	c.631C>G	c.(631-633)CGA>GGA	p.R211G		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	211					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GCCTTACCTCGAAAGAAAATA	0.219													0	0	0	0.001855	0	14	41										C	94964104	G	C	94964104	3	2	81	1	0	0	0	0	1	0	0	0	14089	1066	37	1	629	1	SERPINA12	14	94964104	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2492743	94964104	12385436	157	24301										
RTL1	388015	broad.mit.edu	37	chr14	101349412	101349412	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctggtcggaagtctcatcatCtgcttccttcgggttaaaca	9	11	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:101349412C>G	uc010txj.1	-	1	1773	c.1714G>C	c.(1714-1716)GAT>CAT	p.D572H	uc001yig.3_RNA|MIR127_hsa-mir-127|MI0000472_RNA|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	572										pancreas(1)	1						GTCTCATCATCTGCTTCCTTC	0.572													0	0	0	0.00308	0	7	13										G	101349412	C	G	101349412	3	3	81	1	0	0	0	0	1	0	0	0	13724	913	32	1	2366	1	RTL1	14	101349412	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	6385308	101349412	6000128	158	24302										
AHNAK2	113146	broad.mit.edu	37	chr14	105413526	105413526	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttcaggtccacgttggggccCttaacatctatctgggggcc	12	12	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:105413526C>A	uc010axc.1	-	7	8382	c.8262G>T	c.(8260-8262)AAG>AAT	p.K2754N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K2654N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2754						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CGTTGGGGCCCTTAACATCTA	0.612													1	0	4.31119e-35	0.00361	4.63053e-35	100	172										A	105413526	C	A	105413526	3	1	81	1	0	0	0	0	1	0	0	0	415	680	24	4	9129	4	AHNAK2	14	105413526	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	4064114	105413526	1936014	159	24303										
ACTC1	70	broad.mit.edu	37	chr15	35083368	35083368	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gatttccttctgcatacgatCagcaataccagggtacatag	8	10	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:35083368C>G	uc001ziu.1	-	6	1180	c.937G>C	c.(937-939)GAT>CAT	p.D313H	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	313					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TGCATACGATCAGCAATACCA	0.443													0	0	0	0.00361	0	77	152										G	35083368	C	G	35083368	3	3	81	1	0	0	0	0	1	0	0	0	195	826	29	1	204	1	ACTC1	15	35083368	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		35083368	67448024	160	24304										
RPUSD2	27079	broad.mit.edu	37	chr15	40864067	40864067	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccaagacagctgcagtctctGagagaattcacgagcaggtt	11	10	2	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:40864067G>A	uc001zmd.1	+	2	871	c.871G>A	c.(871-873)GAG>AAG	p.E291K		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	291					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TGCAGTCTCTGAGAGAATTCA	0.552													0	0	0	0.003755	0	31	81										A	40864067	G	A	40864067	3	1	81	1	0	0	0	0	1	0	0	0	13667	1291	45	1	877	1	RPUSD2	15	40864067	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	5780699	40864067	61667325	161	24305										
CTDSPL2	51496	broad.mit.edu	37	chr15	44778881	44778881	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acctgtcttcaactttttttCaccagcaaataaaaatggta	4	9	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:44778881C>T	uc001ztr.2	+	4	874	c.458C>T	c.(457-459)TCA>TTA	p.S153L	CTDSPL2_uc001zts.2_Missense_Mutation_p.S153L|CTDSPL2_uc001ztt.2_Missense_Mutation_p.S153L|CTDSPL2_uc010bdv.2_Missense_Mutation_p.S153L	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	153							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		AACTTTTTTTCACCAGCAAAT	0.289													0	0	0	0.00333	0	22	80										T	44778881	C	T	44778881	3	4	81	1	0	0	0	0	1	0	0	0	4006	838	29	1	468	1	CTDSPL2	15	44778881	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	3914814	44778881	57752511	162	24306										
BCL2L10	10017	broad.mit.edu	37	chr15	52402123	52402123	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctggaccagctgttttctCcaaaaagccagtggaaaggg	12	10	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:52402123C>A	uc002abq.2	-	2	586	c.537G>T	c.(535-537)TGG>TGT	p.W179C		NM_020396	NP_065129	Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	169					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding				0				all cancers(107;0.0148)		GCTGTTTTCTCCAAAAAGCCA	0.438													1	0	1.63498e-16	0.00361	1.72416e-16	65	110										A	52402123	C	A	52402123	3	1	81	1	0	0	0	0	1	0	0	0	1368	856	30	3	81	3	BCL2L10	15	52402123	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	7623242	52402123	50129269	163	24307										
TCF12	6938	broad.mit.edu	37	chr15	57545488	57545488	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatggaggatcgtttagacaGactggatgatgcaatccatg	12	6	0	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:57545488G>C	uc002aec.2	+	15	1501	c.1217G>C	c.(1216-1218)AGA>ACA	p.R406T	TCF12_uc010ugm.1_Missense_Mutation_p.R458T|TCF12_uc010ugn.1_Missense_Mutation_p.R426T|TCF12_uc002aea.2_Missense_Mutation_p.R430T|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Missense_Mutation_p.R430T|TCF12_uc002aed.2_Missense_Mutation_p.R406T|TCF12_uc002aee.2_Missense_Mutation_p.R236T|TCF12_uc010bft.2_Missense_Mutation_p.R260T|TCF12_uc010ugo.1_Missense_Mutation_p.R170T|TCF12_uc010ugp.1_Missense_Mutation_p.R64T|TCF12_uc010ugq.1_Missense_Mutation_p.R40T|TCF12_uc010ugr.1_Missense_Mutation_p.R19T	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	406					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CGTTTAGACAGACTGGATGAT	0.443			T	TEC	extraskeletal myxoid chondrosarcoma								0	0	0	0.005443	0	23	66										C	57545488	G	C	57545488	3	2	81	1	0	0	0	0	1	0	0	0	15684	942	33	1	1420	1	TCF12	15	57545488	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	5143365	57545488	44985904	164	24308										
SPG21	51324	broad.mit.edu	37	chr15	65275846	65275846	+	Frame_Shift_Del	DEL	T	T	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atagtaaaaccatacataccTttttaaggggaactgtacct							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:65275846delT	uc002aod.2	-	2	155	c.62delA	c.(61-63)AAGfs	p.K21fs	SPG21_uc002aoe.2_Frame_Shift_Del_p.K21fs|SPG21_uc010bhb.2_Frame_Shift_Del_p.K21fs|SPG21_uc010bhc.2_5'UTR	NM_001127889	NP_001121361	Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 isoform a	21					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding				0						CATACATACCTTTTTAAGGGG	0.333																		2	4	---	---								-	65275846	T	-	65275846	7	5	81	1	0	1	0	1	0	0	0	0	15042	1623	56	0	896	0	SPG21	15	65275846	Frame_Shift_Del	DEL	T	TCGA-FD-A3SM-01A-11D-A22Z-08	7730358	65275846	37255546	165	24309										
CRAMP1L	57585	broad.mit.edu	37	chr16	1712505	1712505	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcccaggtttgagaaaccctCcaagacccctcttggtgcct	8	15	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:1712505C>G	uc010uvh.1	+	11	2428	c.2428C>G	c.(2428-2430)CCA>GCA	p.P810A	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	810						nucleus	DNA binding				0						GAGAAACCCTCCAAGACCCCT	0.547													0	0	0	0.00361	0	52	98										G	1712505	C	G	1712505	3	3	81	1	0	0	0	0	1	0	0	0	3846	855	30	1	2470	1	CRAMP1L	16	1712505	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		1712505	88642248	166	24310										
CREBBP	1387	broad.mit.edu	37	chr16	3819201	3819201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cctgggctcccctttggattCaccaggatcgggctcagtgt	12	13	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:3819201C>T	uc002cvv.2	-	15	3238	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CREBBP_uc002cvw.2_Missense_Mutation_p.E974K	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1012					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCTTTGGATTCACCAGGATCG	0.592			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.005524	0	36	57										T	3819201	C	T	3819201	3	4	81	1	0	0	0	0	1	0	0	0	3861	835	29	1	4362	1	CREBBP	16	3819201	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2106696	3819201	86535552	167	24311										
SEC14L5	9717	broad.mit.edu	37	chr16	5040888	5040888	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgaagcagtacaccgccaacGtcaagagggtaagcggtggg	15	9	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:5040888G>A	uc002cye.2	+	5	646	c.466G>A	c.(466-468)GTC>ATC	p.V156I		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	156	PRELI/MSF1.					integral to membrane|intracellular	transporter activity				0						CACCGCCAACGTCAAGAGGGT	0.403													0	0	0	0.009096	0	4	7										A	5040888	G	A	5040888	3	1	81	1	0	0	0	0	1	0	0	0	13985	1145	40	2	480	2	SEC14L5	16	5040888	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1221687	5040888	85313865	168	24312										
PLK1	5347	broad.mit.edu	37	chr16	23690256	23690256	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cagcgcagcttcgggagcatGagtgctgcagtgactgcagg	16	10	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:23690256G>A	uc002dlz.1	+	1	56	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	1					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		TCGGGAGCATGAGTGCTGCAG	0.682													0	0	0	0.004672	0	3	3										A	23690256	G	A	23690256	3	1	81	1	0	0	0	0	1	0	0	0	12094	1290	45	1	5	1	PLK1	16	23690256	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	18649368	23690256	66664497	169	24313										
TNRC6A	27327	broad.mit.edu	37	chr16	24800967	24800967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggatgctcctgaaagcaaatCtgaaagtagcaacaatagaa	9	7	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:24800967C>T	uc002dmm.2	+	6	1118	c.1004C>T	c.(1003-1005)TCT>TTT	p.S335F	TNRC6A_uc010bxs.2_Missense_Mutation_p.S82F|TNRC6A_uc010vcc.1_Missense_Mutation_p.S82F|TNRC6A_uc002dmn.2_Missense_Mutation_p.S82F|TNRC6A_uc002dmo.2_Missense_Mutation_p.S82F	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	335	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Ser-rich.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GAAAGCAAATCTGAAAGTAGC	0.438													0	0	0	0.004878	0	39	49										T	24800967	C	T	24800967	3	4	81	1	0	0	0	0	1	0	0	0	16337	913	32	1	1026	1	TNRC6A	16	24800967	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1110711	24800967	65553786	170	24314										
CCDC101	112869	broad.mit.edu	37	chr16	28601977	28601977	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aggtagatgacatcgatgaaGaaggcaaagagtgagtgtcc	14	5	0	6			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:28601977G>C	uc002dqf.2	+	8	777	c.592G>C	c.(592-594)GAA>CAA	p.E198Q	uc010vct.1_Intron	NM_138414	NP_612423	Q96ES7	SGF29_HUMAN	coiled-coil domain containing 101	198	SGF29 C-terminal.				establishment of protein localization to chromatin|histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|SAGA-type complex	methylated histone residue binding			central_nervous_system(1)	1						CATCGATGAAGAAGGCAAAGA	0.577													0	0	0	0.00361	0	77	138										C	28601977	G	C	28601977	3	2	81	1	0	0	0	0	1	0	0	0	2735	943	33	1	618	1	CCDC101	16	28601977	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3801010	28601977	61752776	171	24315										
CDH11	1009	broad.mit.edu	37	chr16	65032529	65032529	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aggaactccggagggttgtcAttaatgtcctggaccttgac	12	9	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:65032529A>G	uc002eoi.2	-	4	893	c.459T>C	c.(457-459)AAT>AAC	p.N153N	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.N153N|CDH11_uc010vin.1_Silent_p.N27N|CDH11_uc010vio.1_Silent_p.N153N	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	153	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GAGGGTTGTCATTAATGTCCT	0.582			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.008361	0	29	55										G	65032529	A	G	65032529	2	3	81	1	0	0	0	0	0	0	0	1	3097	214	8	5		5	CDH11	16	65032529	Silent	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	36430552	65032529	25322224	172	24316										
CDH5	1003	broad.mit.edu	37	chr16	66432402	66432402	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	agacaaggacataacaccacGaaacgtgaagttcaaattca	7	9	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:66432402G>A	uc002eom.3	+	10	1685	c.1529G>A	c.(1528-1530)CGA>CAA	p.R510Q		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	510	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ATAACACCACGAAACGTGAAG	0.443													0	0	0	0.004007	0	16	35										A	66432402	G	A	66432402	3	1	81	1	0	0	0	0	1	0	0	0	3113	1058	37	1	1563	1	CDH5	16	66432402	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1399873	66432402	23922351	173	24317										
PARD6A	50855	broad.mit.edu	37	chr16	67696116	67696116	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctggtacgtgggggtctgGctgagagtacagggctgctg	19	8	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:67696116G>A	uc002ett.2	+	3	698	c.607G>A	c.(607-609)GCT>ACT	p.A203T	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Missense_Mutation_p.A202T|PARD6A_uc002etu.2_Missense_Mutation_p.A27T	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	203	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TGGGGGTCTGGCTGAGAGTAC	0.597													0	0	0	0.005524	0	39	67										A	67696116	G	A	67696116	3	1	81	1	0	0	0	0	1	0	0	0	11445	1203	42	2	617	2	PARD6A	16	67696116	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1263714	67696116	22658637	174	24318										
NFAT5	10725	broad.mit.edu	37	chr16	69693744	69693744	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttggtttttcgagttaatatCatgaggaaagatggctccac	10	6	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:69693744C>G	uc002exm.1	+	6	2465	c.1257C>G	c.(1255-1257)ATC>ATG	p.I419M	NFAT5_uc002exh.1_Missense_Mutation_p.I213M|NFAT5_uc002exi.2_Missense_Mutation_p.I343M|NFAT5_uc002exj.1_Missense_Mutation_p.I343M|NFAT5_uc002exk.1_Missense_Mutation_p.I343M|NFAT5_uc002exl.1_Missense_Mutation_p.I437M|NFAT5_uc002exn.1_Missense_Mutation_p.I437M	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	419	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGTTAATATCATGAGGAAAG	0.398													0	0	0	0.003214	0	46	61										G	69693744	C	G	69693744	3	3	81	1	0	0	0	0	1	0	0	0	10360	816	29	1	1337	1	NFAT5	16	69693744	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1997628	69693744	20661009	175	24319										
HYDIN	54768	broad.mit.edu	37	chr16	70934909	70934909	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggatgtgtgaagcctcacctCcaaccgaatagccttcttga	9	12	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:70934909C>A	uc002ezr.2	-	53	9171	c.9043G>T	c.(9043-9045)GAG>TAG	p.E3015*		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3016										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGCCTCACCTCCAACCGAATA	0.418													1	0	1.414e-09	0.003755	1.4645e-09	24	181										A	70934909	C	A	70934909	4	1	81	1	0	0	0	0	0	1	0	0	7467	864	30	3	6455	3	HYDIN	16	70934909	Nonsense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1241165	70934909	19419844	176	24320										
C16orf7	9605	broad.mit.edu	37	chr16	89779125	89779125	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cctccagtggcgtcagctctCtggaaatgtgacaagctgct	11	12	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:89779125C>T	uc002fom.1	-	5	557	c.432_splice	c.e5-1	p.K144_splice	C16orf7_uc002fol.1_Splice_Site_p.K74_splice|uc002fon.1_RNA	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7						ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CGTCAGCTCTCTGGAAATGTG	0.607													0	0	0	0.004482	0	9	26										T	89779125	C	T	89779125	5	4	81	1	0	0	0	0	0	0	1	0	1828	927	32	1	1508	1	C16orf7	16	89779125	Splice_Site	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	18844216	89779125	575628	177	24321										
FANCA	2175	broad.mit.edu	37	chr16	89845229	89845229	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctcttcagagactctataaaCgccacacgggagtcagggac	10	12	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:89845229C>T	uc002fou.1	-	20	1848	c.1806G>A	c.(1804-1806)GCG>GCA	p.A602A	FANCA_uc010vpn.1_Silent_p.A602A	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	602					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		ACTCTATAAACGCCACACGGG	0.478			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00361	0	44	84										T	89845229	C	T	89845229	2	4	81	1	0	0	0	0	0	0	0	1	5662	523	19	2		2	FANCA	16	89845229	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	66104	89845229	509524	178	24322										
FANCA	2175	broad.mit.edu	37	chr16	89858462	89858462	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccaaccaactcctctgcactCagcatcacaaagagctgaaa	5	15	3	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:89858462C>T	uc002fou.1	-	13	1140	c.1098G>A	c.(1096-1098)CTG>CTA	p.L366L	FANCA_uc010vpn.1_Silent_p.L366L	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	366					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		CCTCTGCACTCAGCATCACAA	0.527			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.002299	0	21	73										T	89858462	C	T	89858462	2	4	81	1	0	0	0	0	0	0	0	1	5662	813	29	1		1	FANCA	16	89858462	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	13233	89858462	496291	179	24323										
VPS53	55275	broad.mit.edu	37	chr17	617947	617947	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tccagttcctcctcctccatCattccgccacccggccccct	4	23	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:617947C>G	uc002frn.2	-	1	150	c.3G>C	c.(1-3)ATG>ATC	p.M1I	VPS53_uc010cjo.1_Missense_Mutation_p.M1I|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.M1I|VPS53_uc002fro.2_5'UTR|VPS53_uc010cjp.1_Missense_Mutation_p.M1I	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	1					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		CCTCCTCCATCATTCCGCCAC	0.706													0	0	0	0.004289	0	35	79										G	617947	C	G	617947	3	3	81	1	0	0	0	0	1	0	0	0	17212	826	29	1	2598	1	VPS53	17	617947	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08		617947	80577263	180	24324										
CLEC10A	10462	broad.mit.edu	37	chr17	6979314	6979314	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccttcctcaccattgttgttGagagtagccacctggcaggt	10	12	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:6979314G>A	uc002gek.2	-	6	813	c.510C>T	c.(508-510)CTC>CTT	p.L170L	CLEC10A_uc002gej.2_Silent_p.L143L|CLEC10A_uc002gel.2_Silent_p.L143L|CLEC10A_uc010clv.1_Silent_p.L143L	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	170	Extracellular (Potential).|Potential.				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						CATTGTTGTTGAGAGTAGCCA	0.547													0	0	0	0.00632	0	27	51										A	6979314	G	A	6979314	2	1	81	1	0	0	0	0	0	0	0	1	3495	1277	45	1		1	CLEC10A	17	6979314	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	6361367	6979314	74215896	181	24325										
CLEC10A	10462	broad.mit.edu	37	chr17	6980295	6980295	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cagggtcaccaggtccctctGaaatttggaatctaaacagg	10	10	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:6980295G>A	uc002gek.2	-	4	499	c.196C>T	c.(196-198)CAG>TAG	p.Q66*	CLEC10A_uc002gej.2_Nonsense_Mutation_p.Q66*|CLEC10A_uc002gel.2_Nonsense_Mutation_p.Q66*|CLEC10A_uc010clv.1_Nonsense_Mutation_p.Q66*	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	66	Extracellular (Potential).				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						AGGTCCCTCTGAAATTTGGAA	0.393													0	0	0	0.002096	0	32	47										A	6980295	G	A	6980295	4	1	81	1	0	0	0	0	0	1	0	0	3495	1299	45	1	787	1	CLEC10A	17	6980295	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	981	6980295	74214915	182	24326										
ALOX12B	242	broad.mit.edu	37	chr17	7984221	7984221	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctcaggccggttggggttgcGatgcctccgcaccggagggc	17	13	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:7984221G>A	uc002gjy.1	-	4	769	c.508C>T	c.(508-510)CGC>TGC	p.R170C	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	170	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						TTGGGGTTGCGATGCCTCCGC	0.652										Multiple Myeloma(8;0.094)			0	0	0	0.00361	0	59	95										A	7984221	G	A	7984221	3	1	81	1	0	0	0	0	1	0	0	0	537	1058	37	1	1645	1	ALOX12B	17	7984221	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1003926	7984221	73210989	183	24327										
DNAH9	1770	broad.mit.edu	37	chr17	11607583	11607583	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcatggcatttgccaggctgGaggaaggctatgagagtgcc	16	8	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:11607583G>C	uc002gne.2	+	25	5283	c.5215G>C	c.(5215-5217)GAG>CAG	p.E1739Q	DNAH9_uc010coo.2_Missense_Mutation_p.E1033Q	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1739	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCCAGGCTGGAGGAAGGCTA	0.512													0	0	0	0.006999	0	39	86										C	11607583	G	C	11607583	3	2	81	1	0	0	0	0	1	0	0	0	4608	1175	41	1	5313	1	DNAH9	17	11607583	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3623362	11607583	69587627	184	24328										
SMCR8	140775	broad.mit.edu	37	chr17	18221435	18221435	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctttgcacattatggattttCagaagtggaagcttattggc	10	6	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:18221435C>A	uc002gsy.3	+	1	2842	c.2332C>A	c.(2332-2334)CAG>AAG	p.Q778K		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	778										central_nervous_system(1)	1						TATGGATTTTCAGAAGTGGAA	0.522													1	0	1.38658e-30	0.00361	1.48379e-30	47	92										A	18221435	C	A	18221435	3	1	81	1	0	0	0	0	1	0	0	0	14792	827	29	3	2334	3	SMCR8	17	18221435	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	6613852	18221435	62973775	185	24329										
PSMD11	5717	broad.mit.edu	37	chr17	30807212	30807212	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgattcttgacaagaaatttCatggtaagtaacagtcacac	7	7	3	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:30807212C>T	uc010cta.1	+	12	1163	c.1123C>T	c.(1123-1125)CAT>TAT	p.H375Y	PSMD11_uc002hhm.2_Missense_Mutation_p.H375Y	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	375	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			CAAGAAATTTCATGGTAAGTA	0.408													0	0	0	0.00361	0	46	81										T	30807212	C	T	30807212	3	4	81	1	0	0	0	0	1	0	0	0	12694	826	29	1	1169	1	PSMD11	17	30807212	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	12585777	30807212	50387998	186	24330										
GAS2L2	246176	broad.mit.edu	37	chr17	34079687	34079687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgttggcacagcaccaggccCgtttccagcacctgcaggaa	11	14	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:34079687C>T	uc002hjv.1	-	1	211	c.183G>A	c.(181-183)ACG>ACA	p.T61T		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	61	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCACCAGGCCCGTTTCCAGCA	0.627													0	0	0	0.00333	0	25	51										T	34079687	C	T	34079687	2	4	81	1	0	0	0	0	0	0	0	1	6247	639	23	2		2	GAS2L2	17	34079687	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	3272475	34079687	47115523	187	24331										
ACACA	31	broad.mit.edu	37	chr17	35614640	35614640	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctcacgaaattgcctcttctCtgttttctccccaagaaaag	5	13	4	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:35614640C>T	uc002hnm.2	-	14	1891	c.1700G>A	c.(1699-1701)AGA>AAA	p.R567K	ACACA_uc002hnk.2_Missense_Mutation_p.R489K|ACACA_uc002hnl.2_Missense_Mutation_p.R509K|ACACA_uc002hnn.2_Missense_Mutation_p.R567K|ACACA_uc002hno.2_Missense_Mutation_p.R604K|ACACA_uc010cuz.2_Missense_Mutation_p.R567K	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	567	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGCCTCTTCTCTGTTTTCTCC	0.378													0	0	0	0.007413	0	17	44										T	35614640	C	T	35614640	3	4	81	1	0	0	0	0	1	0	0	0	106	913	32	1	5512	1	ACACA	17	35614640	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1534953	35614640	45580570	188	24332										
HELZ	9931	broad.mit.edu	37	chr17	65104787	65104787	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgatgctcgctccactgctgGaaccgtgcctgctgctgcct	11	15	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:65104787G>A	uc010wqk.1	-	30	4735	c.4548C>T	c.(4546-4548)TTC>TTT	p.F1516F	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.F1515F|HELZ_uc010der.2_Silent_p.F59F	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCCACTGCTGGAACCGTGCCT	0.502													0	0	0	0.004878	0	37	61										A	65104787	G	A	65104787	2	1	81	1	0	0	0	0	0	0	0	1	7049	1165	41	1		1	HELZ	17	65104787	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	29490147	65104787	16090423	189	24333										
KIAA0195	9772	broad.mit.edu	37	chr17	73491426	73491426	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gagggccactcggacctcatCagcttccagcctacggacag	11	15	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:73491426C>T	uc002jnz.3	+	21	3065	c.2790C>T	c.(2788-2790)ATC>ATT	p.I930I	KIAA0195_uc010wsa.1_Silent_p.I940I|KIAA0195_uc010wsb.1_Silent_p.I570I|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	930					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGGACCTCATCAGCTTCCAGC	0.597													0	0	0	0.007413	0	16	53										T	73491426	C	T	73491426	2	4	81	1	0	0	0	0	0	0	0	1	8160	816	29	1		1	KIAA0195	17	73491426	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8386639	73491426	7703784	190	24334										
EVPL	2125	broad.mit.edu	37	chr17	74005847	74005847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggaggactcctggaggagccCtgggtcctgctccaccttct	13	14	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:74005847C>T	uc002jqi.2	-	22	3667	c.3439G>A	c.(3439-3441)GGG>AGG	p.G1147R	EVPL_uc010wss.1_Missense_Mutation_p.G1169R|EVPL_uc010wst.1_Missense_Mutation_p.G617R	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1147	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TGGAGGAGCCCTGGGTCCTGC	0.632													0	0	0	0.004878	0	30	55										T	74005847	C	T	74005847	3	4	81	1	0	0	0	0	1	0	0	0	5292	681	24	2	2666	2	EVPL	17	74005847	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	514421	74005847	7189363	191	24335										
NDC80	10403	broad.mit.edu	37	chr18	2608705	2608705	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctttatcctgataggaagcaGaggaagaggatgaaaaatgt	12	4	0	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:2608705G>C	uc002kli.2	+	15	1746	c.1564G>C	c.(1564-1566)GAG>CAG	p.E522Q		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	522	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.|Interaction with PSMC2 and SMC1A.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						ATAGGAAGCAGAGGAAGAGGA	0.388													0	0	0	0.005443	0	24	40										C	2608705	G	C	2608705	3	2	81	1	0	0	0	0	1	0	0	0	10242	943	33	1	1618	1	NDC80	18	2608705	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		2608705	75468543	192	24336										
MYOM1	8736	broad.mit.edu	37	chr18	3164366	3164366	+	Frame_Shift_Del	DEL	G	G	-													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttcatcttctttgttgagatGggaaaatgtcagcgttgccc							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:3164366delG	uc002klp.2	-	10	1745	c.1411delC	c.(1411-1413)CATfs	p.H471fs	MYOM1_uc002klq.2_Frame_Shift_Del_p.H471fs	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	471	Ig-like C2-type 2.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTGTTGAGATGGGAAAATGTC	0.393																		9	15	---	---								-	3164366	G	-	3164366	7	5	81	1	0	1	0	1	0	0	0	0	10091	1348	47	0	3762	0	MYOM1	18	3164366	Frame_Shift_Del	DEL	G	TCGA-FD-A3SM-01A-11D-A22Z-08	555661	3164366	74912882	193	24337										
CEP192	55125	broad.mit.edu	37	chr18	13068356	13068356	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aatttttcttttaattttatAggatccagaatttctgatga	5	4	2	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:13068356A>G	uc010xac.1	+	24	4839	c.4759_splice	c.e24-2	p.D1587_splice	CEP192_uc010dlf.1_Splice_Site|CEP192_uc010xad.1_Splice_Site_p.D1112_splice|CEP192_uc002kru.2_Splice_Site|CEP192_uc002krv.2_Splice_Site_p.D9_splice|CEP192_uc002krw.2_5'Flank	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa											ovary(4)|pancreas(1)	5						TTAATTTTATAGGATCCAGAA	0.294													0	0	0	0.006122	0	18	27										G	13068356	A	G	13068356	5	3	81	1	0	0	0	0	0	0	1	0	3251	434	15	5	4847	5	CEP192	18	13068356	Splice_Site	SNP	A	TCGA-FD-A3SM-01A-11D-A22Z-08	9903990	13068356	65008892	194	24338										
KIAA1012	22878	broad.mit.edu	37	chr18	29437531	29437531	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tggctgctttttgacactttCatagtaaaacaaaaagttaa	6	6	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:29437531C>T	uc002kxc.3	-	20	3524	c.3160G>A	c.(3160-3162)GAA>AAA	p.E1054K	KIAA1012_uc002kxb.3_Missense_Mutation_p.E1000K|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1054					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTGACACTTTCATAGTAAAAC	0.348													0	0	0	0.007413	0	18	37										T	29437531	C	T	29437531	3	4	81	1	0	0	0	0	1	0	0	0	8204	835	29	1	1187	1	KIAA1012	18	29437531	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	16369175	29437531	48639717	195	24339										
SMAD2	4087	broad.mit.edu	37	chr18	45372078	45372078	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cagggtgccagccatatctcTgattacaattggggctctgc	11	11	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:45372078T>G	uc002lcy.2	-	9	1339	c.1091A>C	c.(1090-1092)CAG>CCG	p.Q364P	SMAD2_uc002lcz.2_Missense_Mutation_p.Q364P|SMAD2_uc010xdc.1_Missense_Mutation_p.Q334P|SMAD2_uc010xdd.1_Missense_Mutation_p.Q334P	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	364	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						GCCATATCTCTGATTACAATT	0.418													0	0	0	0.007835	0	42	52										G	45372078	T	G	45372078	3	3	81	1	0	0	0	0	1	0	0	0	14758	1580	55	5	324	5	SMAD2	18	45372078	Missense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	15934547	45372078	32705170	196	24340										
MYO5B	4645	broad.mit.edu	37	chr18	47379927	47379927	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtctgctgctgtttgtccatCtcctccttcagggcctcgag	10	14	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:47379927C>T	uc002leb.2	-	31	4401	c.4113G>A	c.(4111-4113)GAG>GAA	p.E1371E	MYO5B_uc002lea.2_Silent_p.E486E	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1371	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GTTTGTCCATCTCCTCCTTCA	0.617													0	0	0	0.002299	0	21	51										T	47379927	C	T	47379927	2	4	81	1	0	0	0	0	0	0	0	1	10079	912	32	1		1	MYO5B	18	47379927	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2007849	47379927	30697321	197	24341										
PIGN	23556	broad.mit.edu	37	chr18	59824982	59824982	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gagctacatgacctggccgaGattctgttggcacacgtgta	12	10	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:59824982G>T	uc002lii.3	-	5	729	c.281C>A	c.(280-282)TCT>TAT	p.S94Y	PIGN_uc002lij.3_Missense_Mutation_p.S94Y	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	94	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ACCTGGCCGAGATTCTGTTGG	0.378													1	0	0.000602214	0.000602	0.000606396	5	20										T	59824982	G	T	59824982	3	4	81	1	0	0	0	0	1	0	0	0	11893	942	33	3	2622	3	PIGN	18	59824982	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	12445055	59824982	18252266	198	24342										
SERPINB4	6318	broad.mit.edu	37	chr18	61328322	61328322	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcagtgttgtctttggctccTaagaggaccatccctaatgc	10	11	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:61328322T>A	uc002ljg.2	-	1	155	c.129A>T	c.(127-129)TTA>TTT	p.L43F	SERPINB3_uc002lji.2_Missense_Mutation_p.L43F|SERPINB3_uc010dqa.2_Missense_Mutation_p.L43F|SERPINB3_uc010dqb.2_Missense_Mutation_p.L43F|SERPINB3_uc010dqc.2_Missense_Mutation_p.L43F			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	43					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						CTTTGGCTCCTAAGAGGACCA	0.438													0	0	0	0.00361	0	40	100										A	61328322	T	A	61328322	3	1	81	1	0	0	0	0	1	0	0	0	14103	1519	53	5		5	SERPINB4	18	61328322	Missense_Mutation	SNP	T	TCGA-FD-A3SM-01A-11D-A22Z-08	1503340	61328322	16748926	199	24343										
ZNF236	7776	broad.mit.edu	37	chr18	74616410	74616411	+	Missense_Mutation	DNP	AG	AG	GA													0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	attttgtcaatgaagcagatAgaccatacaagtgtttttac							TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:74616410_74616411AG>GA	uc002lmi.2	+	12	2161_2162	c.1963_1964AG>GA	c.(1963-1965)AGA>GAA	p.R655E	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	655					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TGAAGCAGATAGACCATACAAG	0.347													0	0	0	0.004672	0	18	23										GA	74616411	AG	GA	74616410	3	3	81	1	0	0	0	0	1	0	0	0	17786	412	15	5	2009	5	ZNF236	18	74616410	Missense_Mutation	DNP	AG	TCGA-FD-A3SM-01A-11D-A22Z-08	13288088	74616410	3460838	200	24344										
PTPRS	5802	broad.mit.edu	37	chr19	5222225	5222225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttttcaccttgaagttcttgGgcgagactgccggggaggcg	15	9	2	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:5222225G>A	uc002mbv.2	-	19	3344	c.3110C>T	c.(3109-3111)CCC>CTC	p.P1037L	PTPRS_uc002mbu.1_Missense_Mutation_p.P606L|PTPRS_uc010xin.1_Missense_Mutation_p.P606L|PTPRS_uc002mbw.2_Missense_Mutation_p.P1015L|PTPRS_uc002mbx.2_Missense_Mutation_p.P610L|PTPRS_uc002mby.2_Missense_Mutation_p.P606L	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1037	Extracellular (Potential).|Fibronectin type-III 8.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GAAGTTCTTGGGCGAGACTGC	0.607													0	0	0	0.004672	0	3	39										A	5222225	G	A	5222225	3	1	81	1	0	0	0	0	1	0	0	0	12811	1232	43	2	2816	2	PTPRS	19	5222225	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		5222225	53906758	201	24345										
AP1M2	10053	broad.mit.edu	37	chr19	10689595	10689595	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atgatctccacgcggctgtgGgagaacttctcaatgacaga	11	10	2	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:10689595G>C	uc002mpc.2	-	8	945	c.861C>G	c.(859-861)TCC>TCG	p.S287S	AP1M2_uc002mpd.2_Silent_p.S289S	NM_005498	NP_005489	Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	287	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CGCGGCTGTGGGAGAACTTCT	0.418													0	0	0	0.004672	0	3	18										C	10689595	G	C	10689595	2	2	81	1	0	0	0	0	0	0	0	1	735	1219	43	4		4	AP1M2	19	10689595	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	5467370	10689595	48439388	202	24346										
SMARCA4	6597	broad.mit.edu	37	chr19	11168977	11168977	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcttcatccagctgccctcgCgaaaggagctgcccgagtac	10	15	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:11168977C>T	uc002mqf.3	+	31	4755	c.4471C>T	c.(4471-4473)CGA>TGA	p.R1491*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.R1491*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.R1523*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.R1458*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.R1457*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.R1461*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.R1460*|SMARCA4_uc002mqh.3_Nonsense_Mutation_p.R581*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1491	Bromo.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCTGCCCTCGCGAAAGGAGCT	0.637			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.001368	0	13	28										T	11168977	C	T	11168977	4	4	81	1	0	0	0	0	0	1	0	0	14770	760	27	2	4698	2	SMARCA4	19	11168977	Nonsense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	479382	11168977	47960006	203	24347										
FKBP8	23770	broad.mit.edu	37	chr19	18650429	18650429	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctgcacccgtgtgccattctCcagcgacgtctgcagatgta	10	14	2	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:18650429C>G	uc002njk.1	-	3	507	c.394G>C	c.(394-396)GAG>CAG	p.E132Q	FKBP8_uc002nji.1_5'UTR|FKBP8_uc010xqi.1_Missense_Mutation_p.E161Q|FKBP8_uc002njj.1_Missense_Mutation_p.E132Q|FKBP8_uc002njl.1_Missense_Mutation_p.E132Q|FKBP8_uc002njm.1_Missense_Mutation_p.E132Q|FKBP8_uc010ebr.1_Intron|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	132	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						GTGCCATTCTCCAGCGACGTC	0.667													0	0	0	0.00361	0	71	83										G	18650429	C	G	18650429	3	3	81	1	0	0	0	0	1	0	0	0	5914	864	30	1	875	1	FKBP8	19	18650429	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	7481452	18650429	40478554	204	24348										
FKBP8	23770	broad.mit.edu	37	chr19	18650529	18650529	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttcttcctcaacagcccgttCcctgccagggtccagggaca	9	16	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:18650529C>T	uc002njk.1	-	3	407	c.294G>A	c.(292-294)GGG>GGA	p.G98G	FKBP8_uc002nji.1_5'UTR|FKBP8_uc010xqi.1_Silent_p.G127G|FKBP8_uc002njj.1_Silent_p.G98G|FKBP8_uc002njl.1_Silent_p.G98G|FKBP8_uc002njm.1_Silent_p.G98G|FKBP8_uc010ebr.1_Intron|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	98					apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						ACAGCCCGTTCCCTGCCAGGG	0.662													0	0	0	0.00361	0	66	84										T	18650529	C	T	18650529	2	4	81	1	0	0	0	0	0	0	0	1	5914	869	30	1		1	FKBP8	19	18650529	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	100	18650529	40478454	205	24349										
SFRS14	10147	broad.mit.edu	37	chr19	19136463	19136463	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cttagctgtgagcaggccctGagtctccccctttcctagga	10	14	1	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:19136463G>A	uc002nkx.2	-	3	840	c.694C>T	c.(694-696)CAG>TAG	p.Q232*	SFRS14_uc002nkz.1_Nonsense_Mutation_p.Q246*|SFRS14_uc002nla.1_Nonsense_Mutation_p.Q232*|SFRS14_uc002nlb.2_Nonsense_Mutation_p.Q232*|SFRS14_uc010xqk.1_Intron	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	232					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			AGCAGGCCCTGAGTCTCCCCC	0.522													0	0	0	0.004878	0	36	37										A	19136463	G	A	19136463	4	1	81	1	0	0	0	0	0	1	0	0	14170	1299	45	1	2586	1	SFRS14	19	19136463	Nonsense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	485934	19136463	39992520	206	24350										
ZNF682	91120	broad.mit.edu	37	chr19	20118011	20118011	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ccacagcttccatatcttctCagtatcactttttggaatga	5	11	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:20118011C>A	uc002noq.2	-	4	423	c.300G>T	c.(298-300)CTG>CTT	p.L100L	ZNF682_uc002noo.2_Silent_p.L68L|ZNF682_uc002nop.2_Silent_p.L68L|ZNF682_uc010eck.2_Silent_p.L24L	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						CATATCTTCTCAGTATCACTT	0.358													1	0	7.48243e-07	0.006214	7.64051e-07	9	5										A	20118011	C	A	20118011	2	1	81	1	0	0	0	0	0	0	0	1	18086	813	29	3		3	ZNF682	19	20118011	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	981548	20118011	39010972	207	24351										
ANKRD27	84079	broad.mit.edu	37	chr19	33096819	33096819	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtgtttccactgaggtccttCttattgggttttgcattcga	10	8	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:33096819C>G	uc002ntn.1	-	24	2571	c.2415G>C	c.(2413-2415)AAG>AAC	p.K805N		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	805	ANK 9.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					TGAGGTCCTTCTTATTGGGTT	0.512													0	0	0	0.00874	0	41	40										G	33096819	C	G	33096819	3	3	81	1	0	0	0	0	1	0	0	0	655	912	32	1	761	1	ANKRD27	19	33096819	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	12978808	33096819	26032164	208	24352										
GPI	2821	broad.mit.edu	37	chr19	34868692	34868692	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atactcttcaggaggtccccGcgtctggtatgtctccaaca	9	13	4	0	rs148548669		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:34868692G>A	uc002nvg.1	+	6	642	c.539G>A	c.(538-540)CGC>CAC	p.R180H	GPI_uc002nvf.2_Missense_Mutation_p.R219H|GPI_uc010xrv.1_Missense_Mutation_p.R191H|GPI_uc010xrw.1_Missense_Mutation_p.R152H|GPI_uc010edl.1_Missense_Mutation_p.R180H	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	180					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					GGAGGTCCCCGCGTCTGGTAT	0.532													0	0	0	0.005524	0	34	53										A	34868692	G	A	34868692	3	1	81	1	0	0	0	0	1	0	0	0	6611	1087	38	2	682	2	GPI	19	34868692	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	1771873	34868692	24260291	209	24353										
LRFN1	57622	broad.mit.edu	37	chr19	39798949	39798949	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gaacgatgaagacgaggaccGaggcgacgatgacgcccccg	15	12	0	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:39798949G>C	uc002okw.2	-	2	1640	c.1640C>G	c.(1639-1641)TCG>TGG	p.S547W		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	547	Helical; (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GACGAGGACCGAGGCGACGAT	0.667													0	0	0	0.008291	0	11	34										C	39798949	G	C	39798949	3	2	81	1	0	0	0	0	1	0	0	0	8937	1059	37	1	679	1	LRFN1	19	39798949	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	4930257	39798949	19330034	210	24354										
LRFN1	57622	broad.mit.edu	37	chr19	39804928	39804928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	catccagcgtcccgtcccccCggacccgggtccggctggag	13	19	0	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:39804928C>T	uc002okw.2	-	1	1049	c.1049G>A	c.(1048-1050)CGG>CAG	p.R350Q		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	350	Ig-like.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCCGTCCCCCCGGACCCGGGT	0.692													0	0	0	0.001984	0	7	16										T	39804928	C	T	39804928	3	4	81	1	0	0	0	0	1	0	0	0	8937	652	23	2	1274	2	LRFN1	19	39804928	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	5979	39804928	19324055	211	24355										
PSG1	5669	broad.mit.edu	37	chr19	43372352	43372352	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atgctttgtagtaatatggcGgataaagagcttttgtcctg	11	5	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:43372352G>A	uc002ovb.2	-	5	1282	c.1144C>T	c.(1144-1146)CGC>TGC	p.R382C	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Missense_Mutation_p.R382C|PSG1_uc010eio.1_Missense_Mutation_p.R382C|PSG1_uc002oux.1_Missense_Mutation_p.R311C|PSG1_uc002ouy.1_Missense_Mutation_p.R289C|PSG1_uc002ouz.1_Missense_Mutation_p.R382C|PSG1_uc002ova.1_Missense_Mutation_p.R289C|PSG1_uc002ovc.2_Missense_Mutation_p.R289C|PSG1_uc002ovd.1_Missense_Mutation_p.R382C	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	382	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GTAATATGGCGGATAAAGAGC	0.463													0	0	0	0.00361	0	87	198										A	43372352	G	A	43372352	3	1	81	1	0	0	0	0	1	0	0	0	12653	1116	39	2	176	2	PSG1	19	43372352	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3567424	43372352	15756631	212	24356										
ZNF226	7769	broad.mit.edu	37	chr19	44680638	44680638	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcggaattcacatcttcaatCccatcaaagagttcatacag	5	11	5	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:44680638C>G	uc002oyp.2	+	6	1367	c.1223C>G	c.(1222-1224)TCC>TGC	p.S408C	ZNF226_uc002oyq.2_Missense_Mutation_p.S291C|ZNF226_uc002oyr.2_Missense_Mutation_p.S291C|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.S408C|ZNF226_uc002oyt.2_Missense_Mutation_p.S408C	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	408	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CATCTTCAATCCCATCAAAGA	0.443													0	0	0	0.00278	0	24	33										G	44680638	C	G	44680638	3	3	81	1	0	0	0	0	1	0	0	0	17777	855	30	1	1291	1	ZNF226	19	44680638	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1308286	44680638	14448345	213	24357										
APOC1	341	broad.mit.edu	37	chr19	45418151	45418151	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tgcccctccggcctcgccatGaggctcttcctgtcgctccc	9	20	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:45418151G>A	uc002pac.1	+	3	255	c.3G>A	c.(1-3)ATG>ATA	p.M1I	APOC1_uc002pad.1_Missense_Mutation_p.M1I|APOC1_uc002pae.1_Missense_Mutation_p.M1I|APOC1_uc002paf.1_5'Flank	NM_001645	NP_001636	P02654	APOC1_HUMAN	apolipoprotein C-I precursor	1					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GCCTCGCCATGAGGCTCTTCC	0.607													0	0	0	0.000978	0	10	29										A	45418151	G	A	45418151	3	1	81	1	0	0	0	0	1	0	0	0	797	1290	45	1	5	1	APOC1	19	45418151	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	737513	45418151	13710832	214	24358										
GLTSCR1	29998	broad.mit.edu	37	chr19	48204667	48204667	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cggcttcccggccacggcccCctgtcgtcttcagctcccgg	11	20	2	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:48204667C>T	uc002phh.3	+	15	3872	c.3678C>T	c.(3676-3678)CCC>CCT	p.P1226P	GLTSCR1_uc002phi.3_Silent_p.P984P	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1226							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GCCACGGCCCCCTGTCGTCTT	0.692													0	0	0	0.001168	0	6	11										T	48204667	C	T	48204667	2	4	81	1	0	0	0	0	0	0	0	1	6474	610	22	2		2	GLTSCR1	19	48204667	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2786516	48204667	10924316	215	24359										
LRRC4B	94030	broad.mit.edu	37	chr19	51021654	51021654	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tggtgttgccggctgagttcGtcaccatgcacgtgtactgg	14	10	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:51021654G>A	uc002pss.2	-	3	1453	c.1316C>T	c.(1315-1317)ACG>ATG	p.T439M		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	439	Extracellular (Potential).|Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GGCTGAGTTCGTCACCATGCA	0.517													0	0	0	0.002445	0	29	48										A	51021654	G	A	51021654	3	1	81	1	0	0	0	0	1	0	0	0	9007	1145	40	2	829	2	LRRC4B	19	51021654	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	2816987	51021654	8107329	216	24360										
KLK15	55554	broad.mit.edu	37	chr19	51329142	51329142	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gtggtgttgtcacaagggacGtcaccccaggacacaatgcc	12	12	2	0	rs137922291		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:51329142G>A	uc002ptl.2	-	5	712	c.681C>T	c.(679-681)GAC>GAT	p.D227D	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Silent_p.D142D|KLK15_uc002ptn.2_3'UTR|KLK15_uc002pto.2_Silent_p.D226D|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_3'UTR|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	227	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CACAAGGGACGTCACCCCAGG	0.557													0	0	0	0.00499	0	16	28										A	51329142	G	A	51329142	2	1	81	1	0	0	0	0	0	0	0	1	8403	1136	40	2		2	KLK15	19	51329142	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	307488	51329142	7799841	217	24361										
CNOT3	4849	broad.mit.edu	37	chr19	54647809	54647809	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttacagcaaagagggcctggGcctggcccagaaggtagatc	14	10	0	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:54647809G>T	uc002qdj.1	+	6	637	c.326G>T	c.(325-327)GGC>GTC	p.G109V	CNOT3_uc010yel.1_Missense_Mutation_p.G109V|CNOT3_uc002qdi.2_Missense_Mutation_p.G22V|CNOT3_uc002qdk.1_Missense_Mutation_p.G109V|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	109					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAGGGCCTGGGCCTGGCCCAG	0.547													1	0	2.37509e-13	0.010504	2.48656e-13	22	55										T	54647809	G	T	54647809	3	4	81	1	0	0	0	0	1	0	0	0	3620	1203	42	4	344	4	CNOT3	19	54647809	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3318667	54647809	4481174	218	24362										
TNNT1	7138	broad.mit.edu	37	chr19	55649415	55649415	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctctgcccgcttcttggcctCttcctcttccttcctcatct	4	19	6	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:55649415C>T	uc002qjb.3	-	10	504	c.415G>A	c.(415-417)GAG>AAG	p.E139K	TNNT1_uc002qiz.3_Missense_Mutation_p.E69K|TNNT1_uc002qja.3_Missense_Mutation_p.E69K|TNNT1_uc002qjc.3_Missense_Mutation_p.E139K|TNNT1_uc002qje.3_Missense_Mutation_p.E128K|TNNT1_uc002qjd.3_Missense_Mutation_p.E128K|TNNT1_uc002qjf.2_Missense_Mutation_p.E135K	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	139					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		TTCTTGGCCTCTTCCTCTTCC	0.567													0	0	0	0.00361	0	43	79										T	55649415	C	T	55649415	3	4	81	1	0	0	0	0	1	0	0	0	16327	922	32	1	441	1	TNNT1	19	55649415	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	1001606	55649415	3479568	219	24363										
KCNS1	3787	broad.mit.edu	37	chr20	43723922	43723922	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gctgtgtaggccacaccagaGaacactgacacacccacagc	9	15	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:43723922G>A	uc002xnc.2	-	5	1567	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	KCNS1_uc002xnd.2_Silent_p.F390F	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	390	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				CCACACCAGAGAACACTGACA	0.567													0	0	0	0.00245	0	14	40										A	43723922	G	A	43723922	2	1	81	1	0	0	0	0	0	0	0	1	8088	933	33	1		1	KCNS1	20	43723922	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		43723922	19301598	220	24364										
C20orf43	51507	broad.mit.edu	37	chr20	55088466	55088466	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aggatggaggagagaaggctGagagcgaagctggaaaaggt	19	3	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:55088466G>A	uc002xxt.2	+	6	680	c.573G>A	c.(571-573)CTG>CTA	p.L191L	C20orf43_uc010zzf.1_Silent_p.L221L|C20orf43_uc002xxu.2_Silent_p.L191L|C20orf43_uc002xxv.2_Silent_p.L191L|GCNT7_uc010zzg.1_Intron	NM_016407	NP_057491	Q9BY42	CT043_HUMAN	hypothetical protein LOC51507	191										ovary(1)	1			Colorectal(105;0.202)			AGAGAAGGCTGAGAGCGAAGC	0.562													0	0	0	0.004672	0	3	14										A	55088466	G	A	55088466	2	1	81	1	0	0	0	0	0	0	0	1	2112	1277	45	1		1	C20orf43	20	55088466	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	11364544	55088466	7937054	221	24365										
TFAP2C	7022	broad.mit.edu	37	chr20	55206428	55206428	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cagctggcctactcccagtcGgccgacccctactcgcatct	8	19	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:55206428G>A	uc002xya.2	+	2	459	c.216G>A	c.(214-216)TCG>TCA	p.S72S	TFAP2C_uc010zzi.1_5'UTR	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	72	Gln/Pro-rich (transactivation domain).				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			ACTCCCAGTCGGCCGACCCCT	0.701													0	0	0	0.003163	0	15	34										A	55206428	G	A	55206428	2	1	81	1	0	0	0	0	0	0	0	1	15786	1103	39	2		2	TFAP2C	20	55206428	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	117962	55206428	7819092	222	24366										
NPEPL1	79716	broad.mit.edu	37	chr20	57268967	57268967	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctgccgcccggagcgcatCgctgcattgtggtgagtgct	15	13	0	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:57268967C>G	uc010zzs.1	+	2	420	c.325C>G	c.(325-327)CGC>GGC	p.R109G	NPEPL1_uc010zzr.1_Missense_Mutation_p.R61G|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.R81G|NPEPL1_uc002xzp.2_Translation_Start_Site	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	109					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			CGGAGCGCATCGCTGCATTGT	0.701													0	0	0	0.00308	0	8	17										G	57268967	C	G	57268967	3	3	81	1	0	0	0	0	1	0	0	0	10574	884	31	1	177	1	NPEPL1	20	57268967	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	2062539	57268967	5756553	223	24367										
HRH3	11255	broad.mit.edu	37	chr20	60794805	60794805	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	aagtcggagatggcgaggttGagcaggaagaagttgttctg	17	4	1	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:60794805G>C	uc002ycf.2	-	1	519	c.222C>G	c.(220-222)CTC>CTG	p.L74L	HRH3_uc002ycg.2_Silent_p.L74L|HRH3_uc002ych.2_Silent_p.L74L|HRH3_uc002yci.2_Silent_p.L74L	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	74	Helical; Name=2; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	TGGCGAGGTTGAGCAGGAAGA	0.682													0	0	0	0.001882	0	18	46										C	60794805	G	C	60794805	2	2	81	1	0	0	0	0	0	0	0	1	7357	1277	45	1		1	HRH3	20	60794805	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	3525838	60794805	2230715	224	24368										
PRDM15	63977	broad.mit.edu	37	chr21	43298877	43298877	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gacccgcatgggctgtacccGagggcgggggataacgacat	16	11	0	0	rs75817094		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr21:43298877G>A	uc002yzq.1	-	3	451	c.340C>T	c.(340-342)CGG>TGG	p.R114W	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCTGTACCCGAGGGCGGGGG	0.493													0	0	0	0.001855	0	12	6										A	43298877	G	A	43298877	3	1	81	1	0	0	0	0	1	0	0	0	12456	1057	37	1	4299	1	PRDM15	21	43298877	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		43298877	4831018	225	24369										
SLC25A18	83733	broad.mit.edu	37	chr22	18070755	18070755	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ttaacaacctggggttcaacGagctcgccggtaaggcgtcc	12	12	1	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:18070755G>A	uc002zmp.1	+	9	1134	c.640G>A	c.(640-642)GAG>AAG	p.E214K	SLC25A18_uc010gqx.2_Missense_Mutation_p.E214K|SLC25A18_uc002zmq.1_Missense_Mutation_p.E214K	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	214						integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GGGGTTCAACGAGCTCGCCGG	0.532													0	0	0	0.007835	0	42	69										A	18070755	G	A	18070755	3	1	81	1	0	0	0	0	1	0	0	0	14480	1059	37	1	666	1	SLC25A18	22	18070755	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		18070755	33233811	226	24370										
CHEK2	11200	broad.mit.edu	37	chr22	29091193	29091193	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctgatccttcagtgacacttGagtcctatgctcagagaaag	9	10	2	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:29091193G>C	uc003adu.1	-	12	1369	c.1297C>G	c.(1297-1299)CAA>GAA	p.Q433E	CHEK2_uc003ads.1_Missense_Mutation_p.Q212E|CHEK2_uc010gvh.1_Missense_Mutation_p.Q342E|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.Q476E|CHEK2_uc003adv.1_Missense_Mutation_p.Q404E|CHEK2_uc003adw.1_Missense_Mutation_p.Q433E|CHEK2_uc003adx.1_Missense_Mutation_p.Q212E|CHEK2_uc003ady.1_Missense_Mutation_p.Q422E|CHEK2_uc003adz.1_Missense_Mutation_p.Q237E	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	433	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AGTGACACTTGAGTCCTATGC	0.413			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.000978	0	11	28										C	29091193	G	C	29091193	3	2	81	1	0	0	0	0	1	0	0	0	3335	1299	45	1	350	1	CHEK2	22	29091193	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	11020438	29091193	22213373	227	24371										
CHEK2	11200	broad.mit.edu	37	chr22	29091207	29091207	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	acacttgagtcctatgctcaGagaaaggtggatacccacta	9	10	1	2	rs137853011	byFrequency	TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:29091207G>A	uc003adu.1	-	12	1355	c.1283C>T	c.(1282-1284)TCT>TTT	p.S428F	CHEK2_uc003ads.1_Missense_Mutation_p.S207F|CHEK2_uc010gvh.1_Missense_Mutation_p.S337F|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.S471F|CHEK2_uc003adv.1_Missense_Mutation_p.S399F|CHEK2_uc003adw.1_Missense_Mutation_p.S428F|CHEK2_uc003adx.1_Missense_Mutation_p.S207F|CHEK2_uc003ady.1_Intron|CHEK2_uc003adz.1_Missense_Mutation_p.S232F	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	428	Protein kinase.		S -> F (increases breast cancer risk approximately 2-fold among Ashkenazi Jewish women).		cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCTATGCTCAGAGAAAGGTGG	0.398			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.000978	0	11	29										A	29091207	G	A	29091207	3	1	81	1	0	0	0	0	1	0	0	0	3335	942	33	1	364	1	CHEK2	22	29091207	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	14	29091207	22213359	228	24372										
EP300	2033	broad.mit.edu	37	chr22	41556722	41556722	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gggatgacccttcccagcctCaaacgtaagtaactgcatta	8	12	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:41556722C>G	uc003azl.3	+	20	4062	c.3667C>G	c.(3667-3669)CAA>GAA	p.Q1223E		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1223					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1198_L1243del(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTCCCAGCCTCAAACGTAAGT	0.388			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.005443	0	26	41										G	41556722	C	G	41556722	3	3	81	1	0	0	0	0	1	0	0	0	5148	827	29	1	3745	1	EP300	22	41556722	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	12465515	41556722	9747844	229	24373										
BRD1	23774	broad.mit.edu	37	chr22	50216812	50216812	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctggaggcgtgtggacatcaCagtaagcggtctttctgacg	14	9	3	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:50216812C>T	uc003biv.2	-	1	1641	c.1154G>A	c.(1153-1155)TGT>TAT	p.C385Y	BRD1_uc011arf.1_Translation_Start_Site|BRD1_uc011arg.1_Missense_Mutation_p.C385Y|BRD1_uc011arh.1_Missense_Mutation_p.C385Y|BRD1_uc003biu.3_Missense_Mutation_p.C385Y	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	385					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGGACATCACAGTAAGCGGT	0.542													0	0	0	0.00361	0	66	112										T	50216812	C	T	50216812	3	4	81	1	0	0	0	0	1	0	0	0	1501	478	17	2	2070	2	BRD1	22	50216812	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	8660090	50216812	1087754	230	24374										
TTLL8	164714	broad.mit.edu	37	chr22	50470355	50470355	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcctgggccaccttcatggcGtgggcgatggccttcttcat	12	13	3	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:50470355G>A	uc011ark.1	-	11	1467	c.1467C>T	c.(1465-1467)CAC>CAT	p.H489H		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CCTTCATGGCGTGGGCGATGG	0.642													0	0	0	0.00278	0	25	36										A	50470355	G	A	50470355	2	1	81	1	0	0	0	0	0	0	0	1	16730	1136	40	2		2	TTLL8	22	50470355	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	253543	50470355	834211	231	24375										
PLXNB2	23654	broad.mit.edu	37	chr22	50717351	50717351	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	cggtacacctggtcaatgatCttctccttgacctgggagat	10	11	3	3			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:50717351C>T	uc003bkv.3	-	28	4585	c.4479G>A	c.(4477-4479)AAG>AAA	p.K1493K	PLXNB2_uc003bkt.1_Silent_p.K285K|PLXNB2_uc003bku.1_Silent_p.K478K	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1493	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCAATGATCTTCTCCTTGA	0.642													0	0	0	0.001368	0	11	31										T	50717351	C	T	50717351	2	4	81	1	0	0	0	0	0	0	0	1	12124	912	32	1		1	PLXNB2	22	50717351	Silent	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	246996	50717351	587215	232	24376										
CCDC120	90060	broad.mit.edu	37	chrX	48925325	48925325	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcctgcccccagaggctgccGaaggccctgaggtgcatcca	13	16	0	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:48925325G>C	uc010nik.2	+	10	2077	c.1570G>C	c.(1570-1572)GAA>CAA	p.E524Q	CCDC120_uc011mmq.1_Missense_Mutation_p.E512Q|CCDC120_uc004dmf.2_Missense_Mutation_p.E524Q|CCDC120_uc010nil.2_Missense_Mutation_p.E524Q|CCDC120_uc011mmr.1_Missense_Mutation_p.E524Q|CCDC120_uc011mms.1_Missense_Mutation_p.E512Q	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	524	Pro-rich.						protein binding			pancreas(1)	1						AGAGGCTGCCGAAGGCCCTGA	0.657													0	0	0	0.009096	0	4	0										C	48925325	G	C	48925325	3	2	81	1	0	0	0	0	1	0	0	0	2756	1059	37	1	1600	1	CCDC120	23	48925325	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08		48925325	106345235	233	24377										
UBQLN2	29978	broad.mit.edu	37	chrX	56591564	56591564	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	gcccgctgtttactgcaaatCctcagctgcaggagcagatg	11	12	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:56591564C>G	uc004dus.2	+	1	1493	c.1258C>G	c.(1258-1260)CCT>GCT	p.P420A	UBQLN2_uc011moq.1_Missense_Mutation_p.P420A	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	420						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						TACTGCAAATCCTCAGCTGCA	0.542													0	0	0	0.000978	0	12	5										G	56591564	C	G	56591564	3	3	81	1	0	0	0	0	1	0	0	0	16894	855	30	1	1260	1	UBQLN2	23	56591564	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	7666239	56591564	98678996	234	24378										
ZC3H12B	340554	broad.mit.edu	37	chrX	64722819	64722819	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ggctaccactcctatcccttGagtaacagcctcatgcaacc	6	16	1	1			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:64722819G>C	uc010nko.2	+	5	2217	c.2208G>C	c.(2206-2208)TTG>TTC	p.L736F		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	736							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						CCTATCCCTTGAGTAACAGCC	0.557													0	0	0	0.003163	0	16	11										C	64722819	G	C	64722819	3	2	81	1	0	0	0	0	1	0	0	0	17559	1281	45	1	2259	1	ZC3H12B	23	64722819	Missense_Mutation	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	8131255	64722819	90547741	235	24379										
TMEM31	203562	broad.mit.edu	37	chrX	102968912	102968912	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tttttattattgtcttcattCtgatcttcttctgattcttt	3	7	7	2			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:102968912C>G	uc004elh.2	+	3	684	c.493C>G	c.(493-495)CTG>GTG	p.L165V	GLRA4_uc011mse.1_Intron	NM_182541	NP_872347	Q5JXX7	TMM31_HUMAN	transmembrane protein 31	165	Helical; (Potential).					integral to membrane					0						tgtcttcattctgatcttctt	0.159													0	0	0	0.001984	0	7	2										G	102968912	C	G	102968912	3	3	81	1	0	0	0	0	1	0	0	0	16152	912	32	1	499	1	TMEM31	23	102968912	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	38246093	102968912	52301648	236	24380										
STAG2	10735	broad.mit.edu	37	chrX	123176495	123176495	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	atgactgaagaattcgatgaGgtaacttactaccttaagtg	9	6	0	4			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:123176495G>A	uc004etz.3	+	6	801	c.462G>A	c.(460-462)GAG>GAA	p.E154E	STAG2_uc004eua.2_Silent_p.E154E|STAG2_uc004eub.2_Silent_p.E154E|STAG2_uc004euc.2_Silent_p.E154E|STAG2_uc004eud.2_Silent_p.E154E|STAG2_uc004eue.2_Silent_p.E154E	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	154					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AATTCGATGAGGTAACTTACT	0.279													0	0	0	0.00245	0	15	5										A	123176495	G	A	123176495	2	1	81	1	0	0	0	0	0	0	0	1	15242	1014	35	2		2	STAG2	23	123176495	Silent	SNP	G	TCGA-FD-A3SM-01A-11D-A22Z-08	20207583	123176495	32094065	237	24381										
ENOX2	10495	broad.mit.edu	37	chrX	129771250	129771250	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	caggagtttcagctgctgttCtttgttagggtcatcttctc	10	9	5	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:129771250C>G	uc004evw.2	-	12	1769	c.1351G>C	c.(1351-1353)GAA>CAA	p.E451Q	ENOX2_uc004evx.2_Missense_Mutation_p.E422Q|ENOX2_uc004evy.2_Missense_Mutation_p.E422Q|ENOX2_uc004evv.2_Missense_Mutation_p.E276Q	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	451	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						AGCTGCTGTTCTTTGTTAGGG	0.473													0	0	0	0.00361	0	83	44										G	129771250	C	G	129771250	3	3	81	1	0	0	0	0	1	0	0	0	5127	922	32	1	501	1	ENOX2	23	129771250	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	6594755	129771250	25499310	238	24382			3	109		2	2	13	C		9.186617e-05
ENOX2	10495	broad.mit.edu	37	chrX	129771262	129771262	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	ctgctgttctttgttagggtCatcttctctgtggactttgc	10	9	4	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:129771262C>A	uc004evw.2	-	12	1757	c.1339G>T	c.(1339-1341)GAC>TAC	p.D447Y	ENOX2_uc004evx.2_Missense_Mutation_p.D418Y|ENOX2_uc004evy.2_Missense_Mutation_p.D418Y|ENOX2_uc004evv.2_Missense_Mutation_p.D272Y	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	447	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						TTGTTAGGGTCATCTTCTCTG	0.473													1	0	5.00475e-40	0.00361	5.39545e-40	84	41										A	129771262	C	A	129771262	3	1	81	1	0	0	0	0	1	0	0	0	5127	826	29	3	513	3	ENOX2	23	129771262	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	12	129771262	25499298	239	24383			3	109		2	2	13	C		9.186617e-05
SPANXC	64663	broad.mit.edu	37	chrX	140336533	140336533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.459915611814346	109	1.39011523475467e-39	3.90904889546169	4.88084422391502	3.14282565571964	0.188241907507416	0.335225314739234	81	tcttaccgtctcattcacctCgttggattcacaggggacgc	9	13	4	0			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:140336533C>T	uc004fbk.2	-	1	114	c.58G>A	c.(58-60)GAG>AAG	p.E20K	SPANXC_uc004fbl.2_Intron	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	20						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					TCATTCACCTCGTTGGATTCA	0.303													0	0	0	0.00361	0	52	30										T	140336533	C	T	140336533	3	4	81	1	0	0	0	0	1	0	0	0	14987	893	31	1	243	1	SPANXC	23	140336533	Missense_Mutation	SNP	C	TCGA-FD-A3SM-01A-11D-A22Z-08	10565271	140336533	14934027	240	24384										
MIB2	142678	broad.mit.edu	37	chr1	1563943	1563943	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gccgtgcaacaggcccacgtGgggctggtgccgctactggt	16	13	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:1563943G>A	uc001agg.2	+	16	2344	c.2217G>A	c.(2215-2217)GTG>GTA	p.V739V	MIB2_uc001agh.2_Silent_p.V725V|MIB2_uc001agi.2_Silent_p.V735V|MIB2_uc001agj.2_Silent_p.V580V|MIB2_uc001agk.2_Silent_p.V674V|MIB2_uc001agl.1_Silent_p.V695V|MIB2_uc001agm.2_Silent_p.V616V|MIB2_uc010nyq.1_Silent_p.V695V|MIB2_uc009vkh.2_Silent_p.V545V|MIB2_uc001agn.2_Silent_p.V371V|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	739	ANK 7.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGGCCCACGTGGGGCTGGTGC	0.697													0	0	0	1	0	3	9										A	1563943	G	A	1563943	2	1	82	1	0	0	0	0	0	0	0	1	9567	1335	47	2		2	MIB2	1	1563943	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		1563943	247686678	1	24385										
PTCHD2	57540	broad.mit.edu	37	chr1	11586880	11586880	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctacgtggccaccaaggagcAgcagcacacccggtaacaga	11	14	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:11586880A>G	uc001ash.3	+	13	2924	c.2786A>G	c.(2785-2787)CAG>CGG	p.Q929R	PTCHD2_uc001asi.1_Missense_Mutation_p.Q929R	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	929	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		ACCAAGGAGCAGCAGCACACC	0.592													0	0	0	1	0	13	40										G	11586880	A	G	11586880	3	3	82	1	0	0	0	0	1	0	0	0	12733	188	7	5	2832	5	PTCHD2	1	11586880	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	10022937	11586880	237663741	2	24386										
NPPB	4879	broad.mit.edu	37	chr1	11918889	11918889	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaggtgctgtctggggatccAtgtctctggagggactgcgg	17	8	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:11918889A>T	uc001atj.2	-	1	104	c.2T>A	c.(1-3)ATG>AAG	p.M1K		NM_002521	NP_002512	P16860	ANFB_HUMAN	natriuretic peptide precursor B preproprotein	1					body fluid secretion|cGMP biosynthetic process|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation	extracellular space	diuretic hormone activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)	Carvedilol(DB01136)|Nesiritide(DB04899)|Testosterone(DB00624)	CTGGGGATCCATGTCTCTGGA	0.532													0	0	0	1	0	24	43										T	11918889	A	T	11918889	3	4	82	1	0	0	0	0	1	0	0	0	10592	217	8	5	414	5	NPPB	1	11918889	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	332009	11918889	237331732	3	24387										
DDI2	84301	broad.mit.edu	37	chr1	15959933	15959933	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttttctcccttatttttgtaGagaaattttctagagtcctg	6	7	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:15959933G>C	uc001awx.1	+	4	602	c.506_splice	c.e4-1	p.E169_splice	DDI2_uc001aww.2_Splice_Site_p.E169_splice|DDI2_uc009voj.1_Splice_Site	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2						proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TATTTTTGTAGAGAAATTTTC	0.393													0	0	0	1	0	78	149										C	15959933	G	C	15959933	5	2	82	1	0	0	0	0	0	0	1	0	4329	956	33	1	519	1	DDI2	1	15959933	Splice_Site	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4041044	15959933	233290688	4	24388										
DDI2	84301	broad.mit.edu	37	chr1	15978369	15978369	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagaattagcagaagcccttCaaaaatcagcagaggatgca	9	8	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:15978369C>G	uc001awx.1	+	8	1258	c.1162C>G	c.(1162-1164)CAA>GAA	p.Q388E	DDI2_uc009voj.1_Missense_Mutation_p.Q129E	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	388					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AGAAGCCCTTCAAAAATCAGC	0.512													0	0	0	1	0	13	16										G	15978369	C	G	15978369	3	3	82	1	0	0	0	0	1	0	0	0	4329	827	29	1	1192	1	DDI2	1	15978369	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	18436	15978369	233272252	5	24389										
CLCNKA	1187	broad.mit.edu	37	chr1	16358726	16358726	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atcctggtaggcatcgtgcaGagggcccagctggtgcaggc	16	11	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:16358726G>A	uc001axu.2	+	17	1865	c.1785G>A	c.(1783-1785)CAG>CAA	p.Q595Q	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.Q595Q|CLCNKA_uc010obw.1_Silent_p.Q552Q|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010oby.1_3'UTR	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	595	CBS 1.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GCATCGTGCAGAGGGCCCAGC	0.642													0	0	0	1	0	15	33										A	16358726	G	A	16358726	2	1	82	1	0	0	0	0	0	0	0	1	3469	933	33	1		1	CLCNKA	1	16358726	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	380357	16358726	232891895	6	24390										
KLHDC7A	127707	broad.mit.edu	37	chr1	18808004	18808004	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctggactcattgcagcagccGacggcagctgtgccggtggt	15	12	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:18808004G>A	uc001bax.2	+	1	581	c.529G>A	c.(529-531)GAC>AAC	p.D177N	KLHDC7A_uc009vpg.2_5'UTR	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	177						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGCAGCAGCCGACGGCAGCTG	0.607													0	0	0	1	0	11	30										A	18808004	G	A	18808004	3	1	82	1	0	0	0	0	1	0	0	0	8360	1058	37	1	531	1	KLHDC7A	1	18808004	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2449278	18808004	230442617	7	24391										
FAM54B	56181	broad.mit.edu	37	chr1	26153217	26153217	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaggagaggcttctggccctGaagaagccagctctgccagc	14	12	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:26153217G>A	uc001bkq.3	+	5	561	c.351G>A	c.(349-351)CTG>CTA	p.L117L	FAM54B_uc001bkr.3_Silent_p.L117L|FAM54B_uc010oet.1_Silent_p.L150L|FAM54B_uc009vrz.2_Silent_p.L114L|FAM54B_uc001bks.3_Silent_p.L117L|FAM54B_uc001bkt.3_Silent_p.L117L|FAM54B_uc001bku.3_Silent_p.L114L|FAM54B_uc001bkv.3_Silent_p.L20L	NM_001099625	NP_001093095	Q9H019	FA54B_HUMAN	hypothetical protein LOC56181 isoform a	117										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.96e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.00095)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTGGCCCTGAAGAAGCCAG	0.607													0	0	0	1	0	33	60										A	26153217	G	A	26153217	2	1	82	1	0	0	0	0	0	0	0	1	5583	1277	45	1		1	FAM54B	1	26153217	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7345213	26153217	223097404	8	24392										
ARID1A	8289	broad.mit.edu	37	chr1	27056181	27056191	+	Frame_Shift_Del	DEL	CAGCCATATGG	CAGCCATATGG	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agatgggcaagatgagacctCagccatatggcgggactaac							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			CAGCCATATGG	-	CAGCCATATGG	CAGCCATATGG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:27056181_27056191delCAGCCATATGG	uc001bmv.1	+	2	1550_1560	c.1177_1187delCAGCCATATGG	c.(1177-1188)CAGCCATATGGCfs	p.Q393fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.Q393fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.Q393fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.Q10fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	393_396					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Y395*(1)|p.Q393*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GATGAGACCTCAGCCATATGGCGGGACTAAC	0.545			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													22	65	---	---								-	27056191	CAGCCATATGG	-	27056181	7	5	82	1	0	1	0	1	0	0	0	0	913	827	29	0	1183	0	ARID1A	1	27056181	Frame_Shift_Del	DEL	CAGCCATATGG	TCGA-FD-A3SN-01A-12D-A22Z-08	902964	27056181	222194440	9	24393										
SLC9A1	6548	broad.mit.edu	37	chr1	27480481	27480481	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaacgggacttacctatcttCatgaggcaggccagaaggat	11	9	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:27480481C>T	uc001bnm.2	-	1	971	c.345G>A	c.(343-345)ATG>ATA	p.M115I	SLC9A1_uc010ofk.1_5'UTR|SLC9A1_uc001bnn.2_Missense_Mutation_p.M115I	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	115	Helical; Name=M2; (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TACCTATCTTCATGAGGCAGG	0.587													0	0	0	1	0	23	50										T	27480481	C	T	27480481	3	4	82	1	0	0	0	0	1	0	0	0	14709	826	29	1	2150	1	SLC9A1	1	27480481	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	424300	27480481	221770140	10	24394										
COL16A1	1307	broad.mit.edu	37	chr1	32157645	32157645	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcacgcccttgatgcctccGtcgcccttctcgcctttctg	9	18	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:32157645G>T	uc001btk.1	-	17	1583	c.1218C>A	c.(1216-1218)GAC>GAA	p.D406E	COL16A1_uc001btj.1_Missense_Mutation_p.D235E|COL16A1_uc001btl.3_Missense_Mutation_p.D406E	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	406	Triple-helical region 9 (COL9) with 3 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TGATGCCTCCGTCGCCCTTCT	0.647													1	0	2.39187e-15	1	2.50233e-15	21	49										T	32157645	G	T	32157645	3	4	82	1	0	0	0	0	1	0	0	0	3673	1136	40	4	3816	4	COL16A1	1	32157645	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4677164	32157645	217092976	11	24395										
CSMD2	114784	broad.mit.edu	37	chr1	33989000	33989000	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acctggagtaggagatgaaaAtcttctttcttgtaagttcc	9	7	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:33989000A>G	uc001bxn.1	-	66	10013	c.9984T>C	c.(9982-9984)GAT>GAC	p.D3328D	CSMD2_uc001bxm.1_Silent_p.D3472D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3328	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAGATGAAAATCTTCTTTCT	0.383													0	0	0	1	0	6	3										G	33989000	A	G	33989000	2	3	82	1	0	0	0	0	0	0	0	1	3945	98	4	5		5	CSMD2	1	33989000	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	1831355	33989000	215261621	12	24396										
SFPQ	6421	broad.mit.edu	37	chr1	35657035	35657035	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttttgaattcatcctccgtGatatcagcaggtagattccc	7	11	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:35657035G>A	uc001bys.2	-	2	1017	c.924C>T	c.(922-924)ATC>ATT	p.I308I	SFPQ_uc001byr.2_5'Flank	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	308	RRM 1.				alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CATCCTCCGTGATATCAGCAG	0.403			T	TFE3	papillary renal cell								0	0	0	1	0	15	16										A	35657035	G	A	35657035	2	1	82	1	0	0	0	0	0	0	0	1	14160	1280	45	1		1	SFPQ	1	35657035	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1668035	35657035	213593586	13	24397										
THRAP3	9967	broad.mit.edu	37	chr1	36762187	36762187	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcttatcttttgataggctGagggaaaatacaaagatgat	11	4	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:36762187G>A	uc001cae.3	+	9	2343	c.2119G>A	c.(2119-2121)GAG>AAG	p.E707K	THRAP3_uc001caf.3_Missense_Mutation_p.E707K	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	707					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTGATAGGCTGAGGGAAAATA	0.408			T	USP6	aneurysmal bone cysts								0	0	0	1	0	27	15										A	36762187	G	A	36762187	3	1	82	1	0	0	0	0	1	0	0	0	15871	1291	45	1	2145	1	THRAP3	1	36762187	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1105152	36762187	212488434	14	24398										
ECHDC2	55268	broad.mit.edu	37	chr1	53387303	53387303	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggaagcgcagccgcgggcccGaaggggcctccaggggcgca	19	14	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:53387303G>A	uc001cup.3	-	1	289	c.43C>T	c.(43-45)CGG>TGG	p.R15W	ECHDC2_uc001cun.2_5'UTR|ECHDC2_uc001cuo.3_Missense_Mutation_p.R15W|ECHDC2_uc010onk.1_5'UTR|ECHDC2_uc010onl.1_5'Flank|ECHDC2_uc010onm.1_5'UTR|ECHDC2_uc010onn.1_5'UTR	NM_018281	NP_060751	Q86YB7	ECHD2_HUMAN	enoyl Coenzyme A hydratase domain containing 2	15					fatty acid metabolic process	mitochondrion	lyase activity			central_nervous_system(1)	1						CCGCGGGCCCGAAGGGGCCTC	0.731													0	0	0	1	0	5	6										A	53387303	G	A	53387303	3	1	82	1	0	0	0	0	1	0	0	0	4894	1057	37	1	778	1	ECHDC2	1	53387303	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	16625116	53387303	195863318	15	24399										
TM2D1	83941	broad.mit.edu	37	chr1	62190818	62190818	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agaccgacactttctcgccaCttccgcttccgcctccgccc	6	21	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:62190818C>T	uc001czz.1	-	1	278	c.-25G>A	c.(-27--23)AAGTG>AAATG			NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor						apoptosis					ovary(1)	1						TTTCTCGCCACTTCCGCTTCC	0.642													0	0	0	1	0	27	37										T	62190818	C	T	62190818	1	4	82	1	0	0	0	0	0	0	0	0	15960	580	20	2		2	TM2D1	1	62190818	Translation_Start_Site	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	8803515	62190818	187059803	16	24400										
C1orf141	400757	broad.mit.edu	37	chr1	67560923	67560923	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgatatgcttattaccatgtGagaagttactgtctttgttg	9	5	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:67560923G>A	uc001ddl.1	-	6	709	c.598C>T	c.(598-600)CAC>TAC	p.H200Y	C1orf141_uc001ddm.1_Missense_Mutation_p.H200Y|C1orf141_uc001ddn.1_Intron	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	200										ovary(1)	1						ATTACCATGTGAGAAGTTACT	0.343													0	0	0	1	0	7	15										A	67560923	G	A	67560923	3	1	82	1	0	0	0	0	1	0	0	0	2001	1290	45	1	612	1	C1orf141	1	67560923	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	5370105	67560923	181689698	17	24401										
ANKRD13C	81573	broad.mit.edu	37	chr1	70736618	70736618	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagtgcttgaagggagctacTacttctaaaacattcaataa	7	7	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:70736618T>C	uc001dex.3	-	12	1742	c.1416A>G	c.(1414-1416)GTA>GTG	p.V472V	ANKRD13C_uc009wbk.2_Silent_p.V437V	NM_030816	NP_110443	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	472					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0						AGGGAGCTACTACTTCTAAAA	0.284													0	0	0	1	0	11	23										C	70736618	T	C	70736618	2	2	82	1	0	0	0	0	0	0	0	1	643	1509	53	5		5	ANKRD13C	1	70736618	Silent	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	3175695	70736618	178514003	18	24402										
ZRANB2	9406	broad.mit.edu	37	chr1	71544365	71544365	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cacatcgattacagctggttCttctagcaaagtttacattt	6	9	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:71544365C>T	uc001dft.2	-	2	150	c.83G>A	c.(82-84)AGA>AAA	p.R28K	uc001dfu.1_5'Flank|ZRANB2_uc001dfs.2_Missense_Mutation_p.R28K	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	28	RanBP2-type 1.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ACAGCTGGTTCTTCTAGCAAA	0.264													0	0	0	1	0	31	64										T	71544365	C	T	71544365	3	4	82	1	0	0	0	0	1	0	0	0	18220	913	32	1	983	1	ZRANB2	1	71544365	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	807747	71544365	177706256	19	24403										
IFI44L	10964	broad.mit.edu	37	chr1	79102839	79102840	+	Frame_Shift_Ins	INS	-	-	A													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctattgacaatctctactctINSaaaatgttggcaaaagtgaa							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:79102839_79102840insA	uc010oro.1	+	6	1178_1179	c.999_1000insA	c.(997-1002)TCTAAAfs	p.S333fs	IFI44L_uc010orp.1_Frame_Shift_Ins_p.S70fs|IFI44L_uc010orq.1_Frame_Shift_Ins_p.S70fs	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	333_334						cytoplasm					0						ATCTCTACTCTAAAATGTTGGC	0.327																		21	52	---	---								A	79102840	-	A	79102839	7	5	82	1	0	1	1	0	0	0	0	0	7518	1509	53	0	1017	0	IFI44L	1	79102839	Frame_Shift_Ins	INS	-	TCGA-FD-A3SN-01A-12D-A22Z-08	7558474	79102839	170147782	20	24404										
GBP4	115361	broad.mit.edu	37	chr1	89654466	89654466	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acaaagtctcccttctttttCtctatggtgtcctgccagaa	6	12	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:89654466C>T	uc001dnb.2	-	8	1325	c.1209G>A	c.(1207-1209)GAG>GAA	p.E403E		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	403				IEKKKGDFV -> KKKKKKKKK (in Ref. 5; AAH17889).		cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CCTTCTTTTTCTCTATGGTGT	0.448													0	0	0	1	0	58	91										T	89654466	C	T	89654466	2	4	82	1	0	0	0	0	0	0	0	1	6276	912	32	1		1	GBP4	1	89654466	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	10551627	89654466	159596155	21	24405										
DR1	1810	broad.mit.edu	37	chr1	93812391	93812391	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atttgtaacaaatcggaaaaGaagaccatctcaccagagca	7	9	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:93812391G>A	uc001dpu.2	+	1	914	c.189G>A	c.(187-189)AAG>AAA	p.K63K	uc001dps.2_5'Flank|uc001dpt.1_5'Flank|DR1_uc010otj.1_Silent_p.K63K	NM_001938	NP_001929	Q01658	NC2B_HUMAN	down-regulator of transcription 1	63					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex	sequence-specific DNA binding|TBP-class protein binding|transcription corepressor activity				0		all_lung(203;0.00252)|Lung NSC(277;0.011)|Melanoma(281;0.155)		all cancers(265;0.0032)|GBM - Glioblastoma multiforme(16;0.0165)|Epithelial(280;0.0977)		AATCGGAAAAGAAGACCATCT	0.468													0	0	0	1	0	7	14										A	93812391	G	A	93812391	2	1	82	1	0	0	0	0	0	0	0	1	4752	933	33	1		1	DR1	1	93812391	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4157925	93812391	155438230	22	24406										
DPYD	1806	broad.mit.edu	37	chr1	98187148	98187148	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcatccacctacacaaagaTcagaggttggacataccatt	7	11	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:98187148T>A	uc001drv.2	-	5	538	c.401A>T	c.(400-402)GAT>GTT	p.D134V	DPYD_uc010oub.1_RNA|DPYD_uc001drw.2_Missense_Mutation_p.D134V	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	134					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TACACAAAGATCAGAGGTTGG	0.383													0	0	0	1	0	12	61										A	98187148	T	A	98187148	3	1	82	1	0	0	0	0	1	0	0	0	4745	1435	50	5	2795	5	DPYD	1	98187148	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	4374757	98187148	151063473	23	24407										
LPPR4	9890	broad.mit.edu	37	chr1	99772144	99772144	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccagtgggatagtgagggttGaggctcacccagagaacaac	14	9	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:99772144G>C	uc001dse.2	+	7	1976	c.1870G>C	c.(1870-1872)GAG>CAG	p.E624Q	LPPR4_uc010oue.1_Missense_Mutation_p.E566Q	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	624							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGTGAGGGTTGAGGCTCACCC	0.562													0	0	0	1	0	20	37										C	99772144	G	C	99772144	3	2	82	1	0	0	0	0	1	0	0	0	8927	1291	45	1	1896	1	LPPR4	1	99772144	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1584996	99772144	149478477	24	24408										
CELSR2	1952	broad.mit.edu	37	chr1	109805873	109805873	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgccccctgggctttgggggCaagagctgcgcccagggtag	17	12	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:109805873C>T	uc001dxa.3	+	8	4879	c.4818C>T	c.(4816-4818)GGC>GGT	p.G1606G		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1606	Extracellular (Potential).|EGF-like 4; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCTTTGGGGGCAAGAGCTGCG	0.637													0	0	0	1	0	8	26										T	109805873	C	T	109805873	2	4	82	1	0	0	0	0	0	0	0	1	3222	697	25	2		2	CELSR2	1	109805873	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	10033729	109805873	139444748	25	24409										
SLC16A1	6566	broad.mit.edu	37	chr1	113456585	113456585	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggagattctgctgctttggtAacttcatttggcttcccagc	10	10	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:113456585A>C	uc001ecx.2	-	5	2263	c.1431T>G	c.(1429-1431)GTT>GTG	p.V477V	SLC16A1_uc001ecy.2_Silent_p.V477V	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	477	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CTGCTTTGGTAACTTCATTTG	0.458													0	0	0	1	0	55	75										C	113456585	A	C	113456585	2	2	82	1	0	0	0	0	0	0	0	1	14402	349	13	5		5	SLC16A1	1	113456585	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	3650712	113456585	135794036	26	24410										
PHTF1	10745	broad.mit.edu	37	chr1	114246790	114246790	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaacgctgtggcccccgtctCtgtggagtgagacacatgtg	14	11	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:114246790C>T	uc009wgp.1	-	14	2256	c.1804_splice	c.e14-1	p.R602_splice	PHTF1_uc001edn.2_Intron|PHTF1_uc001edm.2_Splice_Site_p.R359_splice	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCCCCGTCTCTGTGGAGTGA	0.428													0	0	0	1	0	11	22										T	114246790	C	T	114246790	5	4	82	1	0	0	0	0	0	0	1	0	11862	927	32	1	505	1	PHTF1	1	114246790	Splice_Site	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	790205	114246790	135003831	27	24411										
MAN1A2	10905	broad.mit.edu	37	chr1	117944919	117944919	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaaattcgagcagaaattcaGacagagaaaaataaggtagt	10	4	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:117944919G>A	uc001ehd.1	+	2	1135	c.414G>A	c.(412-414)CAG>CAA	p.Q138Q	MAN1A2_uc009whg.1_Intron	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	138	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		CAGAAATTCAGACAGAGAAAA	0.403													0	0	0	1	0	26	43										A	117944919	G	A	117944919	2	1	82	1	0	0	0	0	0	0	0	1	9211	933	33	1		1	MAN1A2	1	117944919	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3698129	117944919	131305702	28	24412										
WDR3	10885	broad.mit.edu	37	chr1	118502031	118502031	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttggaagagaagaagaggaaGaggaaaaagagggagaagtt	17	0	0	6			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:118502031G>C	uc010oxe.1	+	27	2859	c.2793G>C	c.(2791-2793)AAG>AAC	p.K931N	WDR3_uc001ehi.2_Intron|SPAG17_uc001ehk.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	931						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		agaagaggaagaggaaaaaga	0.299													0	0	0	1	0	14	39										C	118502031	G	C	118502031	3	2	82	1	0	0	0	0	1	0	0	0	17282	933	33	1	2895	1	WDR3	1	118502031	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	557112	118502031	130748590	29	24413										
TBX15	6913	broad.mit.edu	37	chr1	119456781	119456781	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcctttagcaaaagggtttcGgtcaatttttaatctggtaa	8	6	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:119456781G>A	uc001ehl.1	-	6	880	c.565C>T	c.(565-567)CGA>TGA	p.R189*		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	295	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AAAGGGTTTCGGTCAATTTTT	0.333													0	0	0	1	0	15	23										A	119456781	G	A	119456781	4	1	82	1	0	0	0	0	0	1	0	0	15649	1124	39	2	937	2	TBX15	1	119456781	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	954750	119456781	129793840	30	24414										
PDE4DIP	9659	broad.mit.edu	37	chr1	144874026	144874026	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aatgactcgaatgatggatgGaatctataaaatccatgaat	8	5	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:144874026G>A	uc001elw.3	-	31	5222	c.4931C>T	c.(4930-4932)TCC>TTC	p.S1644F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1600F|PDE4DIP_uc001elv.3_Missense_Mutation_p.S651F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1644					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGATGGATGGAATCTATAAA	0.458			T	PDGFRB	MPD								0	0	0	1	0	58	267										A	144874026	G	A	144874026	3	1	82	1	0	0	0	0	1	0	0	0	11643	1174	41	1	2165	1	PDE4DIP	1	144874026	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	25417245	144874026	104376595	31	24415										
PDE4DIP	9659	broad.mit.edu	37	chr1	144917918	144917918	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gagttatctcgatactgtagGagctcccgaaattcctgaga	10	9	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:144917918G>A	uc001elw.3	-	11	1659	c.1368C>T	c.(1366-1368)CTC>CTT	p.L456L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L522L|PDE4DIP_uc001emc.1_Silent_p.L456L|PDE4DIP_uc001emd.1_Silent_p.L456L|PDE4DIP_uc001emb.1_Silent_p.L619L|PDE4DIP_uc001eme.1_5'UTR|PDE4DIP_uc001emf.1_Silent_p.L243L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	456	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GATACTGTAGGAGCTCCCGAA	0.284			T	PDGFRB	MPD								0	0	0	1	0	51	254										A	144917918	G	A	144917918	2	1	82	1	0	0	0	0	0	0	0	1	11643	1161	41	1		1	PDE4DIP	1	144917918	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	43892	144917918	104332703	32	24416										
TCHH	7062	broad.mit.edu	37	chr1	152084109	152084109	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcgctcctcaaccgctgctgGagcctctcttcctcctcctg	7	19	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:152084109G>A	uc001ezp.2	-	2	1584	c.1584C>T	c.(1582-1584)CTC>CTT	p.L528L	TCHH_uc009wne.1_Silent_p.L528L	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	528	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCGCTGCTGGAGCCTCTCTT	0.652													0	0	0	1	0	47	92										A	152084109	G	A	152084109	2	1	82	1	0	0	0	0	0	0	0	1	15697	1161	41	1		1	TCHH	1	152084109	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7166191	152084109	97166512	33	24417										
CREB3L4	148327	broad.mit.edu	37	chr1	153941087	153941087	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggatccgtcctggagctggGactccactgcccccctccag	11	17	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:153941087G>A	uc001fdn.3	+	2	352	c.86G>A	c.(85-87)GGA>GAA	p.G29E	SLC39A1_uc001fdl.2_5'Flank|CREB3L4_uc010pef.1_5'UTR|CREB3L4_uc001fdo.3_Missense_Mutation_p.G29E|CREB3L4_uc001fdm.1_Missense_Mutation_p.G29E|CREB3L4_uc001fdp.1_Missense_Mutation_p.G29E|CREB3L4_uc010peg.1_Missense_Mutation_p.G29E|CREB3L4_uc001fdr.2_Missense_Mutation_p.G29E|CREB3L4_uc001fdq.2_Missense_Mutation_p.G29E	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	29	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGGAGCTGGGACTCCACTGC	0.617													0	0	0	1	0	30	39										A	153941087	G	A	153941087	3	1	82	1	0	0	0	0	1	0	0	0	3859	1174	41	1	88	1	CREB3L4	1	153941087	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1856978	153941087	95309534	34	24418										
CREB3L4	148327	broad.mit.edu	37	chr1	153941855	153941855	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcctgattcctgcatggtcaGtgagctgccctttgatgctc	11	12	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:153941855G>T	uc001fdn.3	+	4	733	c.467G>T	c.(466-468)AGT>ATT	p.S156I	SLC39A1_uc001fdl.2_5'Flank|CREB3L4_uc010pef.1_Missense_Mutation_p.S9I|CREB3L4_uc001fdo.3_Missense_Mutation_p.S136I|CREB3L4_uc001fdm.1_Missense_Mutation_p.S156I|CREB3L4_uc001fdp.1_Missense_Mutation_p.S136I|CREB3L4_uc010peg.1_3'UTR|CREB3L4_uc001fdr.2_Missense_Mutation_p.S156I|CREB3L4_uc001fdq.2_Missense_Mutation_p.S136I	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	156	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGCATGGTCAGTGAGCTGCCC	0.557													1	0	1.62565e-12	1	1.69171e-12	35	45										T	153941855	G	T	153941855	3	4	82	1	0	0	0	0	1	0	0	0	3859	1029	36	4	477	4	CREB3L4	1	153941855	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	768	153941855	95308766	35	24419										
KRTCAP2	200185	broad.mit.edu	37	chr1	155145044	155145044	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctccaatattcacttactctCagggaagatctttgcttgga	7	10	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:155145044C>T	uc001fho.2	-	3	324	c.298G>A	c.(298-300)GAG>AAG	p.E100K	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fhp.1_Missense_Mutation_p.E100K|TRIM46_uc009wpe.1_5'Flank|TRIM46_uc010pez.1_5'Flank|TRIM46_uc001fhq.2_5'Flank|TRIM46_uc001fhr.2_5'Flank|TRIM46_uc001fhs.1_5'Flank|TRIM46_uc001fht.1_5'Flank|TRIM46_uc010pfa.1_5'Flank|TRIM46_uc001fhu.1_5'Flank|TRIM46_uc009wpg.1_5'Flank|TRIM46_uc009wpf.2_5'Flank|TRIM46_uc001fhv.3_5'Flank|TRIM46_uc001fhw.1_5'Flank	NM_173852	NP_776251	Q8N6L1	KTAP2_HUMAN	keratinocyte associated protein 2	100	Helical; (Potential).					integral to membrane					0	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.18e-10)|all cancers(21;8.39e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CACTTACTCTCAGGGAAGATC	0.418													0	0	0	1	0	18	41										T	155145044	C	T	155145044	3	4	82	1	0	0	0	0	1	0	0	0	8578	835	29	1	202	1	KRTCAP2	1	155145044	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1203189	155145044	94105577	36	24420										
ASH1L	55870	broad.mit.edu	37	chr1	155316194	155316194	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctgtccacaggccttgggtCacactgctcacaaaggtagt	10	13	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:155316194C>G	uc009wqq.2	-	21	8365	c.7885G>C	c.(7885-7887)GAC>CAC	p.D2629H	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2624H|MIR555_hsa-mir-555|MI0003561_RNA	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2629	PHD-type.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGCCTTGGGTCACACTGCTCA	0.478													0	0	0	1	0	39	51										G	155316194	C	G	155316194	3	3	82	1	0	0	0	0	1	0	0	0	1041	826	29	1	1056	1	ASH1L	1	155316194	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	171150	155316194	93934427	37	24421										
LRRC52	440699	broad.mit.edu	37	chr1	165532806	165532806	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggcccatcacccgggtgggGaacccactccgatacatgtg	12	14	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:165532806G>A	uc001gde.2	+	2	743	c.687G>A	c.(685-687)GGG>GGA	p.G229G	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	229	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CCCGGGTGGGGAACCCACTCC	0.557													0	0	0	1	0	13	26										A	165532806	G	A	165532806	2	1	82	1	0	0	0	0	0	0	0	1	9010	1161	41	1		1	LRRC52	1	165532806	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	10216612	165532806	83717815	38	24422										
DUSP27	92235	broad.mit.edu	37	chr1	167095044	167095044	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggaaagtcctggtcagcagcGaaatgggcatcagccggtca	14	10	3	0	rs144186156		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:167095044G>A	uc001geb.1	+	5	676	c.676G>A	c.(676-678)GAA>AAA	p.E226K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	226	Tyrosine-protein phosphatase.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GGTCAGCAGCGAAATGGGCAT	0.478													0	0	0	1	0	26	42										A	167095044	G	A	167095044	3	1	82	1	0	0	0	0	1	0	0	0	4824	1059	37	1	694	1	DUSP27	1	167095044	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1562238	167095044	82155577	39	24423										
FMO2	2327	broad.mit.edu	37	chr1	171174530	171174530	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagaaacttctgccatctttGaggatggaacagtggaggag	13	7	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:171174530G>A	uc001ghk.1	+	7	1057	c.940G>A	c.(940-942)GAG>AAG	p.E314K	FMO2_uc010pmd.1_Missense_Mutation_p.E94K	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	314					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCCATCTTTGAGGATGGAAC	0.413													0	0	0	1	0	25	32										A	171174530	G	A	171174530	3	1	82	1	0	0	0	0	1	0	0	0	5955	1291	45	1	962	1	FMO2	1	171174530	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4079486	171174530	78076091	40	24424										
RC3H1	149041	broad.mit.edu	37	chr1	173953689	173953689	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gctaattcttctacacatttCttggcttcctcataatgctt	4	11	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:173953689C>T	uc001gju.3	-	2	387	c.300G>A	c.(298-300)AAG>AAA	p.K100K	RC3H1_uc010pms.1_Silent_p.K100K|RC3H1_uc001gjv.2_Silent_p.K100K|RC3H1_uc010pmt.1_Silent_p.K100K	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	100					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTACACATTTCTTGGCTTCCT	0.383													0	0	0	1	0	12	16										T	173953689	C	T	173953689	2	4	82	1	0	0	0	0	0	0	0	1	13166	912	32	1		1	RC3H1	1	173953689	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2779159	173953689	75296932	41	24425										
C1orf125	126859	broad.mit.edu	37	chr1	179478451	179478451	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaagaatgttatgaatggatCaacacatgctcttgcctcct	7	9	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:179478451C>G	uc001gmo.2	+	21	2536	c.2409C>G	c.(2407-2409)ATC>ATG	p.I803M	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Intron|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	803											0						ATGAATGGATCAACACATGCT	0.348													0	0	0	1	0	14	30										G	179478451	C	G	179478451	3	3	82	1	0	0	0	0	1	0	0	0	1993	816	29	1	2487	1	C1orf125	1	179478451	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5524762	179478451	69772170	42	24426										
CEP350	9857	broad.mit.edu	37	chr1	179993589	179993589	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcaggaggaccattctaacaGaaagtctgcctatgatcctt	8	10	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:179993589G>A	uc001gnt.2	+	14	3805	c.3422G>A	c.(3421-3423)AGA>AAA	p.R1141K	CEP350_uc009wxl.2_Missense_Mutation_p.R1140K|CEP350_uc001gnu.2_Missense_Mutation_p.R974K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1141	Ser-rich.					centrosome|nucleus|spindle				ovary(4)	4						CATTCTAACAGAAAGTCTGCC	0.413													0	0	0	1	0	21	27										A	179993589	G	A	179993589	3	1	82	1	0	0	0	0	1	0	0	0	3254	942	33	1	3472	1	CEP350	1	179993589	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	515138	179993589	69257032	43	24427										
GPR37L1	9283	broad.mit.edu	37	chr1	202092266	202092267	+	In_Frame_Ins	INS	-	-	ACA													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggccaagggcgtgcagcagtINSatgtgcctgaggagtgggcg							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:202092266_202092267insACA	uc001gxj.2	+	1	238_239	c.175_176insACA	c.(175-177)TAT>TACAAT	p.59_60insN		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	59_60	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						CGTGCAGCAGTATGTGCCTGAG	0.673																		14	17	---	---								ACA	202092267	-	ACA	202092266	7	5	82	1	0	1	1	0	0	0	0	0	6692	1638	57	0	177	0	GPR37L1	1	202092266	In_Frame_Ins	INS	-	TCGA-FD-A3SN-01A-12D-A22Z-08	22098677	202092266	47158355	44	24428										
PLEKHA6	22874	broad.mit.edu	37	chr1	204197926	204197926	+	Frame_Shift_Del	DEL	G	G	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttcaactcctcagggctcaGgggagtgtcaggctccaggt							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204197926delG	uc001hau.2	-	20	3132	c.2815delC	c.(2815-2817)CTGfs	p.L939fs		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	939										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TCAGGGCTCAGGGGAGTGTCA	0.557																		15	43	---	---								-	204197926	G	-	204197926	7	5	82	1	0	1	0	1	0	0	0	0	12060	991	35	0	343	0	PLEKHA6	1	204197926	Frame_Shift_Del	DEL	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2105660	204197926	45052695	45	24429										
PLEKHA6	22874	broad.mit.edu	37	chr1	204228552	204228552	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agacgggaaagctgtgctccCtggccggcttggggagtggt	18	9	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204228552C>G	uc001hau.2	-	8	1158	c.841G>C	c.(841-843)GGG>CGG	p.G281R	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	281	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GCTGTGCTCCCTGGCCGGCTT	0.657													0	0	0	1	0	25	51										G	204228552	C	G	204228552	3	3	82	1	0	0	0	0	1	0	0	0	12060	681	24	4	2365	4	PLEKHA6	1	204228552	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	30626	204228552	45022069	46	24430			1	110		3	3	296	C		9.505954e-06
PLEKHA6	22874	broad.mit.edu	37	chr1	204228723	204228723	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tttcttgacttctggcctctCaggccttctctctgccttct	6	15	6	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204228723C>G	uc001hau.2	-	8	987	c.670G>C	c.(670-672)GAG>CAG	p.E224Q	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	224	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TCTGGCCTCTCAGGCCTTCTC	0.652													0	0	0	1	0	19	56										G	204228723	C	G	204228723	3	3	82	1	0	0	0	0	1	0	0	0	12060	835	29	1	2536	1	PLEKHA6	1	204228723	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	171	204228723	45021898	47	24431			1	110		3	3	296	C		9.505954e-06
PLEKHA6	22874	broad.mit.edu	37	chr1	204228847	204228847	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcttgctgggtgggacgttCtccgagtctggcttctcatg	14	10	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:204228847C>G	uc001hau.2	-	8	863	c.546G>C	c.(544-546)GAG>GAC	p.E182D	PLEKHA6_uc009xaw.1_5'Flank|PLEKHA6_uc009xax.1_5'Flank|PLEKHA6_uc009xay.1_5'Flank|PLEKHA6_uc009xaz.1_5'Flank|PLEKHA6_uc009xba.1_5'Flank|PLEKHA6_uc009xbb.1_5'Flank|PLEKHA6_uc009xbc.1_5'Flank	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	182	Pro-rich.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GTGGGACGTTCTCCGAGTCTG	0.627													0	0	0	1	0	12	32										G	204228847	C	G	204228847	3	3	82	1	0	0	0	0	1	0	0	0	12060	912	32	1	2660	1	PLEKHA6	1	204228847	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	124	204228847	45021774	48	24432			1	110		3	3	296	C		9.505954e-06
SYT14	255928	broad.mit.edu	37	chr1	210334350	210334350	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aatgaaagagtcaaaaggacAgcaagtatgtagatggcatg	12	4	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:210334350A>T	uc009xcv.2	+	8	1703	c.1631A>T	c.(1630-1632)CAG>CTG	p.Q544L	SYT14_uc001hhs.3_Missense_Mutation_p.Q608L|SYT14_uc001hht.3_Missense_Mutation_p.Q563L|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Missense_Mutation_p.Q589L|SYT14_uc010pso.1_Missense_Mutation_p.Q506L|SYT14_uc010psp.1_Missense_Mutation_p.Q82L	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	544	Cytoplasmic (Potential).					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		TCAAAAGGACAGCAAGTATGT	0.388													0	0	0	1	0	35	62										T	210334350	A	T	210334350	3	4	82	1	0	0	0	0	1	0	0	0	15467	188	7	5	1861	5	SYT14	1	210334350	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	6105503	210334350	38916271	49	24433										
KCNK2	3776	broad.mit.edu	37	chr1	215259819	215259819	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttcccgggtggagagtgacaCgaccattaatgttatgaaat	11	7	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:215259819C>T	uc001hkq.2	+	2	324	c.155C>T	c.(154-156)ACG>ATG	p.T52M	KCNK2_uc001hko.2_Missense_Mutation_p.T48M|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.T37M	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	52	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	GAGAGTGACACGACCATTAAT	0.512													0	0	0	1	0	15	32										T	215259819	C	T	215259819	3	4	82	1	0	0	0	0	1	0	0	0	8066	536	19	2	204	2	KCNK2	1	215259819	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4925469	215259819	33990802	50	24434										
WDR26	80232	broad.mit.edu	37	chr1	224581534	224581534	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tatacaaaggtattaccttcAatattctggtggtctataaa	6	6	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:224581534A>C	uc001hop.3	-	13	1881	c.1515T>G	c.(1513-1515)ATT>ATG	p.I505M	WDR26_uc001hoq.3_Missense_Mutation_p.I489M|WDR26_uc010pvh.1_Missense_Mutation_p.I212M	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	652						cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		TATTACCTTCAATATTCTGGT	0.388													0	0	0	1	0	25	41										C	224581534	A	C	224581534	3	2	82	1	0	0	0	0	1	0	0	0	17280	126	5	5	37	5	WDR26	1	224581534	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	9321715	224581534	24669087	51	24435										
PCNXL2	80003	broad.mit.edu	37	chr1	233394514	233394514	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	catgtagactcagtgggtctCcgggttgagaagtatcgatg	14	7	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:233394514C>T	uc001hvl.2	-	5	1329	c.1094G>A	c.(1093-1095)GGA>GAA	p.G365E	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	365						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGTGGGTCTCCGGGTTGAGA	0.517													0	0	0	1	0	30	65										T	233394514	C	T	233394514	3	4	82	1	0	0	0	0	1	0	0	0	11592	855	30	1	5439	1	PCNXL2	1	233394514	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	8812980	233394514	15856107	52	24436										
ZNF238	10472	broad.mit.edu	37	chr1	244218534	244218534	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcgagcgcaggttcacgcaGtccggggacctgtacagaca	14	12	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:244218534G>A	uc001iae.2	+	1	1953	c.1431G>A	c.(1429-1431)CAG>CAA	p.Q477Q	ZNF238_uc001iad.3_Silent_p.Q486Q|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	477	C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			GGTTCACGCAGTCCGGGGACC	0.587													0	0	0	1	0	14	42										A	244218534	G	A	244218534	2	1	82	1	0	0	0	0	0	0	0	1	17787	1020	36	2		2	ZNF238	1	244218534	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	10824020	244218534	5032087	53	24437										
AHCTF1	25909	broad.mit.edu	37	chr1	247024465	247024465	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttgtgacccctcatccatttCttgatgctccttttcagggc	7	13	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:247024465C>T	uc001ibu.1	-	28	3875	c.3868G>A	c.(3868-3870)GAA>AAA	p.E1290K	AHCTF1_uc001ibv.1_Missense_Mutation_p.E1299K|AHCTF1_uc009xgs.1_Missense_Mutation_p.E151K|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1290	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TCATCCATTTCTTGATGCTCC	0.423													0	0	0	1	0	15	30										T	247024465	C	T	247024465	3	4	82	1	0	0	0	0	1	0	0	0	408	922	32	1	2964	1	AHCTF1	1	247024465	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2805931	247024465	2226156	54	24438										
NLRP3	114548	broad.mit.edu	37	chr1	247588651	247588651	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aattgttctactgtttgtacGagatgcaggaggaggacttc	12	6	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr1:247588651G>A	uc001icr.2	+	5	2044	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	NLRP3_uc001ics.2_Missense_Mutation_p.E636K|NLRP3_uc001icu.2_Missense_Mutation_p.E636K|NLRP3_uc001icw.2_Missense_Mutation_p.E636K|NLRP3_uc001icv.2_Missense_Mutation_p.E636K|NLRP3_uc010pyw.1_Missense_Mutation_p.E634K|NLRP3_uc001ict.1_Missense_Mutation_p.E634K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	636					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGTTTGTACGAGATGCAGGA	0.478													0	0	0	1	0	20	30										A	247588651	G	A	247588651	3	1	82	1	0	0	0	0	1	0	0	0	10478	1059	37	1	1916	1	NLRP3	1	247588651	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	564186	247588651	1661970	55	24439										
RRM2	6241	broad.mit.edu	37	chr2	10269168	10269168	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agctgtattttggttcctagGagttcctcactgaggccttg	11	9	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:10269168G>A	uc002rah.2	+	9	1095	c.904G>A	c.(904-906)GAG>AAG	p.E302K		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	302					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		TGGTTCCTAGGAGTTCCTCAC	0.438													0	0	0	1	0	37	86										A	10269168	G	A	10269168	3	1	82	1	0	0	0	0	1	0	0	0	13682	1188	41	1	1118	1	RRM2	2	10269168	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		10269168	232930205	56	24440										
C2orf48	348738	broad.mit.edu	37	chr2	10350668	10350668	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tatcctttcactggactccaCacaggcctgcggagcaggtg	11	13	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:10350668C>T	uc002rai.1	+	4	714	c.425C>T	c.(424-426)ACA>ATA	p.T142I		NM_182626	NP_872432	Q96LS8	CB048_HUMAN	hypothetical protein LOC348738	142											0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		CTGGACTCCACACAGGCCTGC	0.567													0	0	0	1	0	31	61										T	10350668	C	T	10350668	3	4	82	1	0	0	0	0	1	0	0	0	2170	478	17	2	435	2	C2orf48	2	10350668	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	81500	10350668	232848705	57	24441										
LAPTM4A	9741	broad.mit.edu	37	chr2	20237361	20237361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagaacagagacggcaaaaaGaacacaggcattatctaaga	9	7	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:20237361G>C	uc002rdm.2	-	3	755	c.247C>G	c.(247-249)CTT>GTT	p.L83V	LAPTM4A_uc002rdn.2_Missense_Mutation_p.L41V|LAPTM4A_uc010yjx.1_Missense_Mutation_p.L73V	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	83	Helical; (Potential).				transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACGGCAAAAAGAACACAGGCA	0.289													0	0	0	1	0	13	21										C	20237361	G	C	20237361	3	2	82	1	0	0	0	0	1	0	0	0	8624	942	33	1	474	1	LAPTM4A	2	20237361	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	9886693	20237361	222962012	58	24442										
ITSN2	50618	broad.mit.edu	37	chr2	24521660	24521660	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcccattctaagcgacgttgTcgttcaagttcctgttttgc	8	11	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:24521660T>C	uc002rfe.2	-	13	1626	c.1368A>G	c.(1366-1368)CGA>CGG	p.R456R	ITSN2_uc002rff.2_Silent_p.R456R|ITSN2_uc002rfg.2_Silent_p.R456R|ITSN2_uc010eyd.2_Silent_p.R481R	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	456	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCGACGTTGTCGTTCAAGTT	0.338													0	0	0	1	0	25	64										C	24521660	T	C	24521660	2	2	82	1	0	0	0	0	0	0	0	1	7927	1654	58	5		5	ITSN2	2	24521660	Silent	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	4284299	24521660	218677713	59	24443										
GPR113	165082	broad.mit.edu	37	chr2	26533881	26533881	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggtattgcccttgaggtagGtagagccccagggtgacacc	14	10	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:26533881G>T	uc002rhe.3	-	11	2715	c.2715C>A	c.(2713-2715)TAC>TAA	p.Y905*	GPR113_uc010yky.1_Nonsense_Mutation_p.Y836*|GPR113_uc002rhb.1_Nonsense_Mutation_p.Y508*|GPR113_uc010eyk.1_Nonsense_Mutation_p.Y706*|GPR113_uc002rhc.1_Nonsense_Mutation_p.Y508*|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	905	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTGAGGTAGGTAGAGCCCCA	0.607													1	0	1.08611e-07	1	1.11449e-07	12	8										T	26533881	G	T	26533881	4	4	82	1	0	0	0	0	0	1	0	0	6630	1256	44	4	625	4	GPR113	2	26533881	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2012221	26533881	216665492	60	24444										
PPP1CB	5500	broad.mit.edu	37	chr2	29004678	29004678	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtctgcctatagcagccattGtggatgagaagatcttctgt	11	8	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:29004678G>C	uc002rmg.2	+	5	650	c.490G>C	c.(490-492)GTG>CTG	p.V164L	PPP1CB_uc010ymj.1_Missense_Mutation_p.V136L|PPP1CB_uc010ymk.1_Missense_Mutation_p.V136L|PPP1CB_uc010yml.1_Missense_Mutation_p.V136L|PPP1CB_uc002rmh.2_Missense_Mutation_p.V164L|SPDYA_uc002rmi.2_5'Flank	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	164					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGCAGCCATTGTGGATGAGAA	0.313													0	0	0	1	0	11	38										C	29004678	G	C	29004678	3	2	82	1	0	0	0	0	1	0	0	0	12350	1377	48	4	504	4	PPP1CB	2	29004678	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2470797	29004678	214194695	61	24445										
FAM179A	165186	broad.mit.edu	37	chr2	29245089	29245089	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagaagaggaggagatggatCttagagcctgtaaggagttg	16	3	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:29245089C>T	uc010ezl.2	+	11	1777	c.1426C>T	c.(1426-1428)CTT>TTT	p.L476F	FAM179A_uc010ymm.1_Missense_Mutation_p.L421F|FAM179A_uc002rmr.3_Missense_Mutation_p.L3F	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	476							binding			ovary(3)|skin(1)	4						GGAGATGGATCTTAGAGCCTG	0.542													0	0	0	1	0	29	59										T	29245089	C	T	29245089	3	4	82	1	0	0	0	0	1	0	0	0	5505	913	32	1	1464	1	FAM179A	2	29245089	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	240411	29245089	213954284	62	24446										
LTBP1	4052	broad.mit.edu	37	chr2	33589339	33589339	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atggccagtgtgttaatacaGagggctcttacaactgcttc	10	9	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:33589339G>A	uc002ros.2	+	30	4459	c.4459G>A	c.(4459-4461)GAG>AAG	p.E1487K	LTBP1_uc002rot.2_Missense_Mutation_p.E1161K|LTBP1_uc002rou.2_Missense_Mutation_p.E1160K|LTBP1_uc002rov.2_Missense_Mutation_p.E1107K|LTBP1_uc010ymz.1_Missense_Mutation_p.E1118K|LTBP1_uc010yna.1_Missense_Mutation_p.E1065K|LTBP1_uc010ynb.1_Missense_Mutation_p.E384K	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1486	EGF-like 16; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGTTAATACAGAGGGCTCTTA	0.423													0	0	0	1	0	24	37										A	33589339	G	A	33589339	3	1	82	1	0	0	0	0	1	0	0	0	9073	943	33	1	4629	1	LTBP1	2	33589339	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4344250	33589339	209610034	63	24447										
TTC7A	57217	broad.mit.edu	37	chr2	47177528	47177528	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttgggaaattgctgctggctGaggccctcctggagcagtgt	15	9	0	1	rs147914967		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:47177528G>A	uc002rvo.2	+	2	579	c.211G>A	c.(211-213)GAG>AAG	p.E71K	TTC7A_uc002rvm.2_Missense_Mutation_p.E37K|TTC7A_uc002rvn.1_5'UTR|TTC7A_uc010fbb.2_Missense_Mutation_p.E71K|TTC7A_uc010fbc.2_5'UTR|TTC7A_uc002rvp.2_5'UTR	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	71							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GCTGCTGGCTGAGGCCCTCCT	0.502													0	0	0	1	0	64	96										A	47177528	G	A	47177528	3	1	82	1	0	0	0	0	1	0	0	0	16709	1291	45	1	217	1	TTC7A	2	47177528	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	13588189	47177528	196021845	64	24448										
ASB3	51130	broad.mit.edu	37	chr2	53992675	53992675	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggcagcaagtccaactgtaGagcacgtgtccgcgtaagcc	12	12	0	1	rs146004165		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:53992675G>C	uc002rxg.1	-	2	170	c.35C>G	c.(34-36)TCT>TGT	p.S12C	ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Missense_Mutation_p.S50C|ASB3_uc010yoo.1_Missense_Mutation_p.S12C|CHAC2_uc002rxk.1_5'Flank|uc002rxj.1_5'Flank	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	12	ANK 1.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCAACTGTAGAGCACGTGTC	0.428													0	0	0	1	0	37	76										C	53992675	G	C	53992675	3	2	82	1	0	0	0	0	1	0	0	0	1024	942	33	1	1557	1	ASB3	2	53992675	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6815147	53992675	189206698	65	24449										
PNPT1	87178	broad.mit.edu	37	chr2	55882034	55882034	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tttgagacataattcttttaCctgaatccattaatgctaaa	4	7	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:55882034C>T	uc002rzf.2	-	18	1548	c.1495_splice	c.e18+1	p.G499_splice	PNPT1_uc002rzg.2_Splice_Site	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AATTCTTTTACCTGAATCCAT	0.204													0	0	0	1	0	20	51										T	55882034	C	T	55882034	5	4	82	1	0	0	0	0	0	0	1	0	12173	521	18	2	899	2	PNPT1	2	55882034	Splice_Site	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1889359	55882034	187317339	66	24450										
USP34	9736	broad.mit.edu	37	chr2	61431458	61431458	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcgcggaggccgaatattgCttttccctcctattagcttg	11	11	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:61431458C>T	uc002sbe.2	-	74	9339	c.9317G>A	c.(9316-9318)AGC>AAC	p.S3106N	USP34_uc002sbd.2_Intron	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3106					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCGAATATTGCTTTTCCCTCC	0.408													0	0	0	1	0	25	42										T	61431458	C	T	61431458	3	4	82	1	0	0	0	0	1	0	0	0	17062	797	28	2	1351	2	USP34	2	61431458	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5549424	61431458	181767915	67	24451										
PLEK	5341	broad.mit.edu	37	chr2	68592492	68592492	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgtccagccagcatggaaccAaagcggatcagagagggcta	13	10	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:68592492A>G	uc002sen.3	+	1	171	c.9A>G	c.(7-9)CCA>CCG	p.P3P	PLEK_uc010fde.2_Silent_p.P3P	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	3					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		GCATGGAACCAAAGCGGATCA	0.597													0	0	0	1	0	32	47										G	68592492	A	G	68592492	2	3	82	1	0	0	0	0	0	0	0	1	12053	117	5	5		5	PLEK	2	68592492	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	7161034	68592492	174606881	68	24452										
ATP6V1B1	525	broad.mit.edu	37	chr2	71192177	71192177	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggagatgctgaagcgcattCcgcaggccgtgatcgacgag	15	10	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:71192177C>T	uc002shj.2	+	14	1555	c.1468C>T	c.(1468-1470)CCG>TCG	p.P490S	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.P473S|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.P448S	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	490					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GAAGCGCATTCCGCAGGCCGT	0.662											OREG0014686	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	26	37										T	71192177	C	T	71192177	3	4	82	1	0	0	0	0	1	0	0	0	1178	855	30	1	1522	1	ATP6V1B1	2	71192177	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2599685	71192177	172007196	69	24453										
TTC31	64427	broad.mit.edu	37	chr2	74718624	74718624	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acaggactcactggatctatCtagcacttttgtgtctctgg	9	10	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:74718624C>T	uc002slt.2	+	8	724	c.701C>T	c.(700-702)TCT>TTT	p.S234F	TTC31_uc002sls.2_Missense_Mutation_p.S163F|TTC31_uc010yrv.1_Missense_Mutation_p.S90F|TTC31_uc002slu.2_Missense_Mutation_p.S90F	NM_022492	NP_071937	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	234							binding				0						CTGGATCTATCTAGCACTTTT	0.542													0	0	0	1	0	88	183										T	74718624	C	T	74718624	3	4	82	1	0	0	0	0	1	0	0	0	16697	913	32	1	731	1	TTC31	2	74718624	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3526447	74718624	168480749	70	24454										
IMMT	10989	broad.mit.edu	37	chr2	86374830	86374830	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agtccaggtcctcacctgctCaaattcagacttcaattcct	5	14	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:86374830C>T	uc002sqz.3	-	13	1916	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	IMMT_uc002sqy.3_Missense_Mutation_p.E251K|IMMT_uc002srb.3_Missense_Mutation_p.E499K|IMMT_uc002sra.3_Missense_Mutation_p.E509K|IMMT_uc010ytd.1_Missense_Mutation_p.E498K|IMMT_uc010yte.1_Missense_Mutation_p.E463K|IMMT_uc002src.1_Missense_Mutation_p.E246K	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	510	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						CTCACCTGCTCAAATTCAGAC	0.483													0	0	0	1	0	21	29										T	86374830	C	T	86374830	3	4	82	1	0	0	0	0	1	0	0	0	7718	835	29	1	760	1	IMMT	2	86374830	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	11656206	86374830	156824543	71	24455										
REEP1	65055	broad.mit.edu	37	chr2	86459890	86459890	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtggtgaggtcctgcatgctGaagctccgcagtctctccga	13	12	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:86459890G>A	uc002srh.3	-	6	597	c.453C>T	c.(451-453)TTC>TTT	p.F151F	REEP1_uc010ytg.1_Silent_p.F130F|REEP1_uc010yth.1_Silent_p.F124F|REEP1_uc010yti.1_Missense_Mutation_p.S73L	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	151					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0						CCTGCATGCTGAAGCTCCGCA	0.667													0	0	0	1	0	13	18										A	86459890	G	A	86459890	2	1	82	1	0	0	0	0	0	0	0	1	13204	1294	45	1		1	REEP1	2	86459890	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	85060	86459890	156739483	72	24456										
EIF2AK3	9451	broad.mit.edu	37	chr2	88890382	88890382	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccttcttactgaatgccataActttccagtcagcaaccgaa	5	13	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:88890382A>G	uc002stc.3	-	5	1158	c.956T>C	c.(955-957)GTT>GCT	p.V319A		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	319	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GAATGCCATAACTTTCCAGTC	0.428													0	0	0	1	0	33	67										G	88890382	A	G	88890382	3	3	82	1	0	0	0	0	1	0	0	0	4998	43	2	5	2446	5	EIF2AK3	2	88890382	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	2430492	88890382	154308991	73	24457										
SNRNP200	23020	broad.mit.edu	37	chr2	96943981	96943981	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tctgctgtcctcacctgcctCaggagattgtcttcatggtg	10	12	5	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:96943981C>G	uc002svu.2	-	39	5690	c.5604G>C	c.(5602-5604)CTG>CTC	p.L1868L	SNRNP200_uc002svt.2_Silent_p.L478L|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1868	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						TCACCTGCCTCAGGAGATTGT	0.552													0	0	0	1	0	29	57										G	96943981	C	G	96943981	2	3	82	1	0	0	0	0	0	0	0	1	14852	813	29	1		1	SNRNP200	2	96943981	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	8053599	96943981	146255392	74	24458										
ANKRD36	375248	broad.mit.edu	37	chr2	97779539	97779539	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgcttgtgctcggatggcttCgcatttccccaataccccat	8	15	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:97779539C>T	uc010yva.1	+	1	307	c.63C>T	c.(61-63)TTC>TTT	p.F21F	ANKRD36_uc002sxn.2_Silent_p.F21F|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Silent_p.F21F|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21											0						CGGATGGCTTCGCATTTCCCC	0.512													0	0	0	1	0	21	61										T	97779539	C	T	97779539	2	4	82	1	0	0	0	0	0	0	0	1	665	883	31	1		1	ANKRD36	2	97779539	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	835558	97779539	145419834	75	24459										
MRPL30	51263	broad.mit.edu	37	chr2	99804704	99804704	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcgtcacaaattcaccagatCaagaattccagaaaaagtaa	5	9	3	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:99804704C>T	uc002szu.2	+	3	278	c.116C>T	c.(115-117)TCA>TTA	p.S39L	MRPL30_uc002szl.1_RNA|MRPL30_uc002szr.2_Missense_Mutation_p.S39L|MRPL30_uc002szt.1_Intron|MRPL30_uc002szv.2_Missense_Mutation_p.S39L	NM_145213	NP_660214	Q8TCC3	RM30_HUMAN	RecName: Full=39S ribosomal protein L30, mitochondrial;          Short=L30mt; AltName: Full=MRP-L30; AltName: Full=MRP-L28; Flags: Precursor;	39					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1						TTCACCAGATCAAGAATTCCA	0.279													0	0	0	1	0	4	8										T	99804704	C	T	99804704	3	4	82	1	0	0	0	0	1	0	0	0	9794	838	29	1	122	1	MRPL30	2	99804704	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2025165	99804704	143394669	76	24460										
REV1	51455	broad.mit.edu	37	chr2	100019151	100019151	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgagcaaggtcttcacatcaTtgaattcaacagctccagct	7	11	4	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:100019151T>C	uc002tad.2	-	21	3709	c.3497A>G	c.(3496-3498)AAT>AGT	p.N1166S	REV1_uc002tac.2_Missense_Mutation_p.N1165S	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	1166	Protein interaction domain; mediates interaction with DNA polymerase zeta.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						CTTCACATCATTGAATTCAAC	0.488								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	28	47										C	100019151	T	C	100019151	3	2	82	1	0	0	0	0	1	0	0	0	13239	1493	52	5	270	5	REV1	2	100019151	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	214447	100019151	143180222	77	24461										
SLC9A4	389015	broad.mit.edu	37	chr2	103142766	103142766	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctacccctacgggaatcctCagtctgcaggaagagacaca	9	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:103142766C>T	uc002tbz.3	+	11	2456	c.1999C>T	c.(1999-2001)CAG>TAG	p.Q667*		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	667	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CGGGAATCCTCAGTCTGCAGG	0.443													0	0	0	1	0	24	44										T	103142766	C	T	103142766	4	4	82	1	0	0	0	0	0	1	0	0	14716	827	29	1	2041	1	SLC9A4	2	103142766	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3123615	103142766	140056607	78	24462										
RANBP2	5903	broad.mit.edu	37	chr2	109369565	109369565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taaaaaagaagaacagtattCctgaacctattgatcctctg	6	8	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:109369565C>T	uc002tem.3	+	13	1993	c.1867C>T	c.(1867-1869)CCT>TCT	p.P623S		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	623					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GAACAGTATTCCTGAACCTAT	0.308													0	0	0	1	0	32	74										T	109369565	C	T	109369565	3	4	82	1	0	0	0	0	1	0	0	0	13028	855	30	1	1917	1	RANBP2	2	109369565	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6226799	109369565	133829808	79	24463										
DPP10	57628	broad.mit.edu	37	chr2	116594297	116594297	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcttgaaagaagaaaatatAttaataattcatggaactgc	8	4	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:116594297A>G	uc002tla.1	+	24	2614	c.2157A>G	c.(2155-2157)ATA>ATG	p.I719M	DPP10_uc002tlb.1_Missense_Mutation_p.I669M|DPP10_uc002tlc.1_Missense_Mutation_p.I715M|DPP10_uc002tle.2_Missense_Mutation_p.I723M|DPP10_uc002tlf.1_Missense_Mutation_p.I712M	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	719	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AAGAAAATATATTAATAATTC	0.333													0	0	0	1	0	44	62										G	116594297	A	G	116594297	3	3	82	1	0	0	0	0	1	0	0	0	4727	439	16	5	2422	5	DPP10	2	116594297	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	7224732	116594297	126605076	80	24464										
TMEM177	80775	broad.mit.edu	37	chr2	120438762	120438762	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcatccctgccagtttcttGggagacctagtgatcaacac	10	12	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:120438762G>A	uc010flg.1	+	2	806	c.333G>A	c.(331-333)TTG>TTA	p.L111L	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Silent_p.L111L|TMEM177_uc002tmd.2_Silent_p.L111L|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	111						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					CCAGTTTCTTGGGAGACCTAG	0.587													0	0	0	1	0	86	167										A	120438762	G	A	120438762	2	1	82	1	0	0	0	0	0	0	0	1	16091	1339	47	2		2	TMEM177	2	120438762	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3844465	120438762	122760611	81	24465										
PTPN4	5775	broad.mit.edu	37	chr2	120725491	120725491	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaatgcaatcagccagtttaTccactagatattgtaagaac	7	8	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:120725491T>C	uc002tmf.1	+	26	3408	c.2637T>C	c.(2635-2637)TAT>TAC	p.Y879Y	PTPN4_uc010flj.1_Silent_p.Y592Y|PTPN4_uc010yyr.1_Silent_p.Y512Y	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	879	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGCCAGTTTATCCACTAGATA	0.373													0	0	0	1	0	32	78										C	120725491	T	C	120725491	2	2	82	1	0	0	0	0	0	0	0	1	12790	1442	50	5		5	PTPN4	2	120725491	Silent	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	286729	120725491	122473882	82	24466										
ERCC3	2071	broad.mit.edu	37	chr2	128046431	128046431	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcaacgtttctggagttcctCaatcatttcctggaaagagg	10	9	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:128046431C>T	uc002toh.1	-	7	927	c.832G>A	c.(832-834)GAG>AAG	p.E278K	ERCC3_uc002toe.1_Missense_Mutation_p.E33K|ERCC3_uc002tof.1_Missense_Mutation_p.E214K|ERCC3_uc002tog.1_Missense_Mutation_p.E214K|ERCC3_uc010flx.1_Missense_Mutation_p.E33K	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	278					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TGGAGTTCCTCAATCATTTCC	0.413			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	70	117										T	128046431	C	T	128046431	3	4	82	1	0	0	0	0	1	0	0	0	5214	835	29	1	1552	1	ERCC3	2	128046431	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7320940	128046431	115152942	83	24467										
BAZ2B	29994	broad.mit.edu	37	chr2	160206422	160206422	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaaccattgtctattcttttCagtcagcgtttttagtaact	5	8	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:160206422C>T	uc002uao.2	-	28	5012	c.4660G>A	c.(4660-4662)GAA>AAA	p.E1554K	BAZ2B_uc002uap.2_Missense_Mutation_p.E1518K	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTATTCTTTTCAGTCAGCGTT	0.428													0	0	0	1	0	61	115										T	160206422	C	T	160206422	3	4	82	1	0	0	0	0	1	0	0	0	1332	835	29	1	1886	1	BAZ2B	2	160206422	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	32159991	160206422	82992951	84	24468										
TBR1	10716	broad.mit.edu	37	chr2	162273101	162273101	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaaattaccagggggatgacGaatcagtcagatacagacaa	10	7	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:162273101G>A	uc002ubw.1	+	1	482	c.180G>A	c.(178-180)ACG>ACA	p.T60T	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	60						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GGGGGATGACGAATCAGTCAG	0.498													0	0	0	1	0	31	60										A	162273101	G	A	162273101	2	1	82	1	0	0	0	0	0	0	0	1	15644	1045	37	1		1	TBR1	2	162273101	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2066679	162273101	80926272	85	24469										
COBLL1	22837	broad.mit.edu	37	chr2	165551902	165551902	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttacggtaagcggatcttctGaatgtataattagggtgcct	11	6	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:165551902G>A	uc010zcw.1	-	15	2439	c.2315C>T	c.(2314-2316)TCA>TTA	p.S772L	COBLL1_uc002ucp.2_Missense_Mutation_p.S705L|COBLL1_uc002ucq.2_Missense_Mutation_p.S667L|COBLL1_uc010zcx.1_Missense_Mutation_p.S713L|COBLL1_uc002ucn.2_Missense_Mutation_p.S133L|COBLL1_uc002uco.2_Missense_Mutation_p.S436L	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	743										ovary(2)|pancreas(1)	3						CGGATCTTCTGAATGTATAAT	0.373													0	0	0	1	0	58	104										A	165551902	G	A	165551902	3	1	82	1	0	0	0	0	1	0	0	0	3654	1294	45	1	1398	1	COBLL1	2	165551902	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3278801	165551902	77647471	86	24470										
TTN	7273	broad.mit.edu	37	chr2	179398127	179398127	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ataatttcaatgttaggcccGagggacagtggctgaccatc	11	9	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:179398127G>A	uc010zfg.1	-	307	95735	c.95511C>T	c.(95509-95511)CTC>CTT	p.L31837L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L25532L|TTN_uc010zfi.1_Silent_p.L25465L|TTN_uc010zfj.1_Silent_p.L25340L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32764							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTAGGCCCGAGGGACAGTG	0.473													0	0	0	1	0	27	51										A	179398127	G	A	179398127	2	1	82	1	0	0	0	0	0	0	0	1	16732	1045	37	1		1	TTN	2	179398127	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	13846225	179398127	63801246	87	24471										
TTN	7273	broad.mit.edu	37	chr2	179422195	179422195	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcctacgactgcactgcctCcatttgacactggttcatgc	8	14	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:179422195C>G	uc010zfg.1	-	278	80314	c.80090G>C	c.(80089-80091)GGA>GCA	p.G26697A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G20392A|TTN_uc010zfi.1_Missense_Mutation_p.G20325A|TTN_uc010zfj.1_Missense_Mutation_p.G20200A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27624							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCACTGCCTCCATTTGACAC	0.458													0	0	0	1	0	24	66										G	179422195	C	G	179422195	3	3	82	1	0	0	0	0	1	0	0	0	16732	855	30	1	20321	1	TTN	2	179422195	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	24068	179422195	63777178	88	24472										
TTN	7273	broad.mit.edu	37	chr2	179429435	179429435	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agaaactttgaactcatactCaaggccctcatcaagcccag	6	13	4	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:179429435C>G	uc010zfg.1	-	275	73944	c.73720G>C	c.(73720-73722)GAG>CAG	p.E24574Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E18269Q|TTN_uc010zfi.1_Missense_Mutation_p.E18202Q|TTN_uc010zfj.1_Missense_Mutation_p.E18077Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25501							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTCATACTCAAGGCCCTCA	0.418													0	0	0	1	0	19	30										G	179429435	C	G	179429435	3	3	82	1	0	0	0	0	1	0	0	0	16732	835	29	1	26703	1	TTN	2	179429435	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7240	179429435	63769938	89	24473										
ITGAV	3685	broad.mit.edu	37	chr2	187466860	187466860	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctacccgccggtgccagccaAttgaatttgatgcaacaggt	10	12	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:187466860A>T	uc002upq.2	+	2	574	c.298A>T	c.(298-300)ATT>TTT	p.I100F	ITGAV_uc010frs.2_Missense_Mutation_p.I100F|ITGAV_uc010zfv.1_Missense_Mutation_p.I54F	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	100	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GTGCCAGCCAATTGAATTTGA	0.423													0	0	0	1	0	17	29										T	187466860	A	T	187466860	3	4	82	1	0	0	0	0	1	0	0	0	7888	101	4	5	355	5	ITGAV	2	187466860	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	8037425	187466860	55732513	90	24474										
TMEFF2	23671	broad.mit.edu	37	chr2	192863864	192863864	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tttgatttggcatgcattatCataagatttcccatcagaag	7	7	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:192863864C>T	uc002utc.2	-	6	1001	c.607G>A	c.(607-609)GAT>AAT	p.D203N		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	203	Kazal-like 2.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			CATGCATTATCATAAGATTTC	0.363													0	0	0	1	0	29	52										T	192863864	C	T	192863864	3	4	82	1	0	0	0	0	1	0	0	0	16011	826	29	1	537	1	TMEFF2	2	192863864	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5397004	192863864	50335509	91	24475										
ALS2	57679	broad.mit.edu	37	chr2	202631985	202631985	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aactccatgtttcactccgaGggctgcctgcaaaacagtct	8	13	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:202631985G>A	uc002uyo.2	-	3	498	c.142C>T	c.(142-144)CTC>TTC	p.L48F	ALS2_uc002uyp.3_Missense_Mutation_p.L48F|ALS2_uc002uyq.2_Missense_Mutation_p.L48F|ALS2_uc002uyr.2_Missense_Mutation_p.L48F	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	48					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TTCACTCCGAGGGCTGCCTGC	0.488													0	0	0	1	0	14	31										A	202631985	G	A	202631985	3	1	82	1	0	0	0	0	1	0	0	0	550	1000	35	2	5037	2	ALS2	2	202631985	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	9768121	202631985	40567388	92	24476										
MAP2	4133	broad.mit.edu	37	chr2	210558419	210558419	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtttggagcaagcagttacaGattcagccatgacctctaaa	9	9	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr2:210558419G>C	uc002vde.1	+	7	1773	c.1525G>C	c.(1525-1527)GAT>CAT	p.D509H	MAP2_uc002vdc.1_Missense_Mutation_p.D509H|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D505H	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	509					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGCAGTTACAGATTCAGCCAT	0.428													0	0	0	1	0	25	26										C	210558419	G	C	210558419	3	2	82	1	0	0	0	0	1	0	0	0	9235	942	33	1	1539	1	MAP2	2	210558419	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7926434	210558419	32640954	93	24477										
KCNH8	131096	broad.mit.edu	37	chr3	19575010	19575010	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gctctttgcacagcacctctGtgtgtccctccagggagagc	11	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:19575010G>T	uc003cbk.1	+	16	2938	c.2743G>T	c.(2743-2745)GTG>TTG	p.V915L	KCNH8_uc010hex.1_Missense_Mutation_p.V376L	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	915	Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CAGCACCTCTGTGTGTCCCTC	0.522													1	0	2.47907e-22	1	2.61679e-22	57	22										T	19575010	G	T	19575010	3	4	82	1	0	0	0	0	1	0	0	0	8038	1377	48	4	2805	4	KCNH8	3	19575010	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		19575010	178447420	94	24478										
NEK10	152110	broad.mit.edu	37	chr3	27346359	27346359	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccagaggagcttcaagtggtCagagtggagcagactgagga	16	7	2	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:27346359C>T	uc003cdt.1	-	13	1181	c.907G>A	c.(907-909)GAC>AAC	p.D303N		NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	303							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTCAAGTGGTCAGAGTGGAGC	0.542													0	0	0	1	0	19	18										T	27346359	C	T	27346359	3	4	82	1	0	0	0	0	1	0	0	0	10322	826	29	1	1283	1	NEK10	3	27346359	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7771349	27346359	170676071	95	24479										
GLB1	2720	broad.mit.edu	37	chr3	33110348	33110348	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagatgtagggcccgggcctCaggataaccagcagtcccag	13	13	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:33110348C>T	uc003cfi.1	-	3	477	c.360G>A	c.(358-360)CTG>CTA	p.L120L	GLB1_uc003cfh.1_Silent_p.L90L|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Silent_p.L168L	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	120					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				GCCCGGGCCTCAGGATAACCA	0.562													0	0	0	1	0	45	27										T	33110348	C	T	33110348	2	4	82	1	0	0	0	0	0	0	0	1	6427	813	29	1		1	GLB1	3	33110348	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5763989	33110348	164912082	96	24480										
XIRP1	165904	broad.mit.edu	37	chr3	39228107	39228107	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agccgggggctcccaccgcaGactgtgcaggccactcaggt	14	15	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:39228107G>A	uc003cjk.1	-	2	3051	c.2830C>T	c.(2830-2832)CTG>TTG	p.L944L	XIRP1_uc003cji.2_Silent_p.L944L|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	944							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TCCCACCGCAGACTGTGCAGG	0.637													0	0	0	1	0	39	14										A	39228107	G	A	39228107	2	1	82	1	0	0	0	0	0	0	0	1	17426	933	33	1		1	XIRP1	3	39228107	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6117759	39228107	158794323	97	24481										
GPR62	118442	broad.mit.edu	37	chr3	51990695	51990695	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gccctgccgtaggcccttctGaggctccagaacagaccccc	10	18	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:51990695G>A	uc003dca.3	+	1	1366	c.1027G>A	c.(1027-1029)GAG>AAG	p.E343K		NM_080865	NP_543141	Q9BZJ7	GPR62_HUMAN	G protein-coupled receptor 62	343	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AGGCCCTTCTGAGGCTCCAGA	0.672													0	0	0	1	0	22	10										A	51990695	G	A	51990695	3	1	82	1	0	0	0	0	1	0	0	0	6703	1291	45	1	1029	1	GPR62	3	51990695	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	12762588	51990695	146031735	98	24482										
ALAS1	211	broad.mit.edu	37	chr3	52246323	52246323	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgtgatgaactaatgagcaGacataacatctacgtgcaag	9	8	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:52246323G>A	uc003dcy.1	+	11	1986	c.1649G>A	c.(1648-1650)AGA>AAA	p.R550K	ALAS1_uc003dcz.1_Missense_Mutation_p.R550K|ALAS1_uc011bec.1_Missense_Mutation_p.R567K	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	550					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CTAATGAGCAGACATAACATC	0.498													0	0	0	1	0	197	72										A	52246323	G	A	52246323	3	1	82	1	0	0	0	0	1	0	0	0	484	942	33	1	1683	1	ALAS1	3	52246323	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	255628	52246323	145776107	99	24483										
ROBO2	6092	broad.mit.edu	37	chr3	77657032	77657032	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccacttgggccaatgtccctCtacctccccccccagtccag	6	21	1	0	rs143136849		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:77657032C>T	uc003dpy.3	+	21	3863	c.3220C>T	c.(3220-3222)CTA>TTA	p.L1074L	ROBO2_uc003dpz.2_Silent_p.L1078L|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.L1078L|ROBO2_uc003dqa.2_Silent_p.L201L	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1074	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.L1074L(1)|p.L1090L(1)		lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAATGTCCCTCTACCTCCCCC	0.423													0	0	0	1	0	10	34										T	77657032	C	T	77657032	2	4	82	1	0	0	0	0	0	0	0	1	13514	912	32	1		1	ROBO2	3	77657032	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	25410709	77657032	120365398	100	24484										
GABRR3	200959	broad.mit.edu	37	chr3	97726706	97726706	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagtatttaaggacttgtttCcgtgtttccagtatagcatt	8	7	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:97726706C>T	uc011bgr.1	-	6	656	c.656G>A	c.(655-657)GGA>GAA	p.G219E		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	219	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0						GGACTTGTTTCCGTGTTTCCA	0.343													0	0	0	1	0	6	13										T	97726706	C	T	97726706	3	4	82	1	0	0	0	0	1	0	0	0	6178	855	30	1	762	1	GABRR3	3	97726706	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	20069674	97726706	100295724	101	24485										
BBX	56987	broad.mit.edu	37	chr3	107474514	107474514	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtggaaagtctgcactctttCaactggcagaggcaagttcc	11	10	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:107474514C>T	uc010hpr.2	+	10	1222	c.895C>T	c.(895-897)CAA>TAA	p.Q299*	BBX_uc003dwk.3_Nonsense_Mutation_p.Q299*|BBX_uc003dwl.3_Nonsense_Mutation_p.Q299*|BBX_uc010hps.1_Nonsense_Mutation_p.Q320*|BBX_uc003dwm.3_Nonsense_Mutation_p.Q299*	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			TGCACTCTTTCAACTGGCAGA	0.368													0	0	0	1	0	25	59										T	107474514	C	T	107474514	4	4	82	1	0	0	0	0	0	1	0	0	1343	827	29	1	921	1	BBX	3	107474514	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	9747808	107474514	90547916	102	24486										
C3orf17	25871	broad.mit.edu	37	chr3	112724493	112724519	+	In_Frame_Del	DEL	CATGGATGCCTCTAAGATTTTCATGAA	CATGGATGCCTCTAAGATTTTCATGAA	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccacgaatcagtttcattttCatggatgcctctaagatttt							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:112724493_112724519delCATGGATGCCTCTAAGATTTTCATGAA	uc003dzr.2	-	9	1629_1655	c.1568_1594delTTCATGAAAATCTTAGAGGCATCCATG	c.(1567-1596)ATTCATGAAAATCTTAGAGGCATCCATGAA>AAA	p.523_532IHENLRGIHE>K	GTPBP8_uc011bhy.1_Intron|C3orf17_uc003dzq.2_In_Frame_Del_p.148_157IHENLRGIHE>K|C3orf17_uc011bhz.1_In_Frame_Del_p.148_157IHENLRGIHE>K|C3orf17_uc010hqh.2_In_Frame_Del_p.148_157IHENLRGIHE>K|C3orf17_uc003dzt.2_In_Frame_Del_p.426_435IHENLRGIHE>K|C3orf17_uc003dzs.2_In_Frame_Del_p.387_396IHENLRGIHE>K|C3orf17_uc010hqg.2_In_Frame_Del_p.348_357IHENLRGIHE>K|C3orf17_uc011bia.1_In_Frame_Del_p.320_329IHENLRGIHE>K|C3orf17_uc003dzu.2_In_Frame_Del_p.452_461IHENLRGIHE>K|C3orf17_uc011bib.1_In_Frame_Del_p.412_421IHENLRGIHE>K|C3orf17_uc011bic.1_In_Frame_Del_p.356_365IHENLRGIHE>K|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	523_532						integral to membrane					0						GTTTCATTTTCATGGATGCCTCTAAGATTTTCATGAATCATTTTCTC	0.361																		26	73	---	---								-	112724519	CATGGATGCCTCTAAGATTTTCATGAA	-	112724493	7	5	82	1	0	1	0	1	0	0	0	0	2210	835	29	0	113	0	C3orf17	3	112724493	In_Frame_Del	DEL	CATGGATGCCTCTAAGATTTTCATGAA	TCGA-FD-A3SN-01A-12D-A22Z-08	5249979	112724493	85297937	103	24487										
GPR156	165829	broad.mit.edu	37	chr3	119905579	119905579	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgtcatgagcaggatcacatCagccatcaacagggctgcca	10	13	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:119905579C>T	uc011bjf.1	-	5	526	c.526G>A	c.(526-528)GAT>AAT	p.D176N	GPR156_uc011bjg.1_Missense_Mutation_p.D176N	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	176	Helical; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		AGGATCACATCAGCCATCAAC	0.502													0	0	0	1	0	32	66										T	119905579	C	T	119905579	3	4	82	1	0	0	0	0	1	0	0	0	6661	826	29	1	1938	1	GPR156	3	119905579	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7181086	119905579	78116851	104	24488										
STXBP5L	9515	broad.mit.edu	37	chr3	121126442	121126442	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgtgctaacggacatatcatGataatgaggtacttgccttc	9	8	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:121126442G>A	uc003eec.3	+	24	3152	c.3012G>A	c.(3010-3012)ATG>ATA	p.M1004I	STXBP5L_uc011bji.1_Missense_Mutation_p.M980I	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	1004	WD 13.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GACATATCATGATAATGAGGT	0.373													0	0	0	1	0	32	35										A	121126442	G	A	121126442	3	1	82	1	0	0	0	0	1	0	0	0	15356	1290	45	1	3102	1	STXBP5L	3	121126442	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1220863	121126442	76895988	105	24489										
POLQ	10721	broad.mit.edu	37	chr3	121251880	121251880	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	attccctcacaagtttcattGaagagtcatatatggaattt	6	7	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:121251880G>T	uc003eee.3	-	6	1046	c.917C>A	c.(916-918)TCA>TAA	p.S306*		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	306					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AAGTTTCATTGAAGAGTCATA	0.383								DNA_polymerases_(catalytic_subunits)					1	0	5.50884e-06	1	5.59432e-06	13	30										T	121251880	G	T	121251880	4	4	82	1	0	0	0	0	0	1	0	0	12208	1294	45	3	6955	3	POLQ	3	121251880	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	125438	121251880	76770550	106	24490										
OSBPL11	114885	broad.mit.edu	37	chr3	125313607	125313607	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccagctttccttcgctctccGagactttcattgtggacact	7	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:125313607G>A	uc003eic.2	-	1	775	c.38C>T	c.(37-39)TCG>TTG	p.S13L		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	13					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						TTCGCTCTCCGAGACTTTCAT	0.408													0	0	0	1	0	15	23										A	125313607	G	A	125313607	3	1	82	1	0	0	0	0	1	0	0	0	11276	1059	37	1	2257	1	OSBPL11	3	125313607	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4061727	125313607	72708823	107	24491										
ATP2C1	27032	broad.mit.edu	37	chr3	130694262	130694262	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagagcaaagggcagaccttGacacttactcagcagcagag	11	11	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:130694262G>A	uc003enl.2	+	18	1722	c.1500G>A	c.(1498-1500)TTG>TTA	p.L500L	ATP2C1_uc011blg.1_Silent_p.L534L|ATP2C1_uc011blh.1_Silent_p.L495L|ATP2C1_uc011bli.1_Silent_p.L534L|ATP2C1_uc003enk.2_Silent_p.L484L|ATP2C1_uc003enm.2_Silent_p.L500L|ATP2C1_uc003enn.2_Silent_p.L484L|ATP2C1_uc003eno.2_Silent_p.L500L|ATP2C1_uc003enp.2_Silent_p.L500L|ATP2C1_uc003enq.2_Silent_p.L500L|ATP2C1_uc003enr.2_Silent_p.L500L|ATP2C1_uc003ens.2_Silent_p.L500L|ATP2C1_uc003ent.2_Silent_p.L500L|ATP2C1_uc003enu.2_Silent_p.L178L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	500	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	GGCAGACCTTGACACTTACTC	0.463									Hailey-Hailey_disease				0	0	0	1	0	25	33										A	130694262	G	A	130694262	2	1	82	1	0	0	0	0	0	0	0	1	1143	1281	45	1		1	ATP2C1	3	130694262	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	5380655	130694262	67328168	108	24492										
STAG1	10274	broad.mit.edu	37	chr3	136076567	136076567	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taatgtgcaacttacactgtCtttttgtcctgtcgaagaag	8	8	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:136076567C>G	uc003era.1	-	28	3352	c.3060G>C	c.(3058-3060)AAG>AAC	p.K1020N	STAG1_uc003erb.1_Missense_Mutation_p.K1020N	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1020					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						CTTACACTGTCTTTTTGTCCT	0.294													0	0	0	1	0	18	34										G	136076567	C	G	136076567	3	3	82	1	0	0	0	0	1	0	0	0	15241	912	32	1	744	1	STAG1	3	136076567	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5382305	136076567	61945863	109	24493										
MRPS22	56945	broad.mit.edu	37	chr3	139071544	139071544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggaaaatatgaccttttacGttcaacaagatactttggtg	8	6	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:139071544G>A	uc003etb.2	+	6	796	c.788G>A	c.(787-789)CGT>CAT	p.R263H	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.R262H|MRPS22_uc003ete.2_Missense_Mutation_p.R222H	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	263						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						GACCTTTTACGTTCAACAAGA	0.323													0	0	0	1	0	21	41										A	139071544	G	A	139071544	3	1	82	1	0	0	0	0	1	0	0	0	9833	1145	40	2	810	2	MRPS22	3	139071544	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2994977	139071544	58950886	110	24494										
MFSD1	64747	broad.mit.edu	37	chr3	158519993	158519993	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcctggcaggcggccctgacGaggccgacagaggtgccccg	16	15	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:158519993G>A	uc003fcl.1	+	1	82	c.52G>A	c.(52-54)GAG>AAG	p.E18K	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_5'UTR|MFSD1_uc011bow.1_Missense_Mutation_p.E18K|MFSD1_uc011box.1_5'UTR	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	18					transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CGGCCCTGACGAGGCCGACAG	0.682													0	0	0	1	0	4	12										A	158519993	G	A	158519993	3	1	82	1	0	0	0	0	1	0	0	0	9527	1059	37	1	201	1	MFSD1	3	158519993	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	19448449	158519993	39502437	111	24495										
KPNA4	3840	broad.mit.edu	37	chr3	160219955	160219955	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaaccaaatgttccgccttgAattgcctctggaacaaggct	8	11	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:160219955A>C	uc003fdn.2	-	17	1809	c.1503T>G	c.(1501-1503)ATT>ATG	p.I501M		NM_002268	NP_002259	O00629	IMA4_HUMAN	karyopherin alpha 4	501					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			TTCCGCCTTGAATTGCCTCTG	0.348													0	0	0	1	0	34	45										C	160219955	A	C	160219955	3	2	82	1	0	0	0	0	1	0	0	0	8432	242	9	5	66	5	KPNA4	3	160219955	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	1699962	160219955	37802475	112	24496										
MYNN	55892	broad.mit.edu	37	chr3	169496653	169496653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggaagattttgcttttattGctaatccttcttctacagag	7	7	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:169496653G>A	uc003fft.2	+	3	793	c.364G>A	c.(364-366)GCT>ACT	p.A122T	MYNN_uc011bpm.1_Missense_Mutation_p.A8T|MYNN_uc003ffu.2_Missense_Mutation_p.A122T|MYNN_uc003ffv.2_Intron|MYNN_uc010hwo.2_Missense_Mutation_p.A122T|MYNN_uc003ffw.1_5'Flank	NM_018657	NP_061127	Q9NPC7	MYNN_HUMAN	myoneurin	122						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TGCTTTTATTGCTAATCCTTC	0.343													0	0	0	1	0	24	56										A	169496653	G	A	169496653	3	1	82	1	0	0	0	0	1	0	0	0	10061	1319	46	2	370	2	MYNN	3	169496653	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	9276698	169496653	28525777	113	24497										
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	20	15										A	178936082	G	A	178936082	3	1	82	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1658	1	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	9439429	178936082	19086348	114	24498										
MCCC1	56922	broad.mit.edu	37	chr3	182804570	182804570	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggggccgatggaatatgcttCatctgcctgtttaagaaaca	11	8	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:182804570C>T	uc003fle.2	-	4	417	c.280G>A	c.(280-282)GAA>AAA	p.E94K	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_Intron|MCCC1_uc003flf.2_Missense_Mutation_p.M17I|MCCC1_uc003flg.2_5'UTR|MCCC1_uc011bqp.1_Missense_Mutation_p.E47K|MCCC1_uc011bqq.1_5'UTR	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	94	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GAATATGCTTCATCTGCCTGT	0.438													0	0	0	1	0	6	5										T	182804570	C	T	182804570	3	4	82	1	0	0	0	0	1	0	0	0	9374	835	29	1	1961	1	MCCC1	3	182804570	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3868488	182804570	15217860	115	24499										
MAGEF1	64110	broad.mit.edu	37	chr3	184429408	184429414	+	Frame_Shift_Del	DEL	CCAAGGC	CCAAGGC	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcggtaggccctgcgccttgCcaaggctttggccgccaagg					rs6770319	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:184429408_184429414delCCAAGGC	uc003fpa.2	-	1	423_429	c.196_202delGCCTTGG	c.(196-204)GCCTTGGCAfs	p.A66fs		NM_022149	NP_071432	Q9HAY2	MAGF1_HUMAN	melanoma antigen family F, 1	66_68								p.L67*(1)		ovary(1)	1	all_cancers(143;4.61e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;5.64e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.56e-22)			CTGCGCCTTGCCAAGGCTTTGGCCGCC	0.681																		33	57	---	---								-	184429414	CCAAGGC	-	184429408	7	5	82	1	0	1	0	1	0	0	0	0	9187	739	26	0	725	0	MAGEF1	3	184429408	Frame_Shift_Del	DEL	CCAAGGC	TCGA-FD-A3SN-01A-12D-A22Z-08	1624838	184429408	13593022	116	24500										
C3orf59	151963	broad.mit.edu	37	chr3	192516517	192516517	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcatgttgcactgagggatGaaataattggggcacatctt	12	6	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:192516517G>A	uc011bsp.1	-	2	1455	c.1134C>T	c.(1132-1134)TTC>TTT	p.F378F		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	378											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		ACTGAGGGATGAAATAATTGG	0.532													0	0	0	1	0	19	46										A	192516517	G	A	192516517	2	1	82	1	0	0	0	0	0	0	0	1	2237	1281	45	1		1	C3orf59	3	192516517	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	8087109	192516517	5505913	117	24501										
RNF168	165918	broad.mit.edu	37	chr3	196198864	196198864	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acttgcctatttttgtccctTgagcctctctctggtgttgg	9	11	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:196198864T>A	uc003fwq.2	-	6	2080	c.1542A>T	c.(1540-1542)TCA>TCT	p.S514S	RNF168_uc010iah.2_Silent_p.S347S|uc010iag.1_5'Flank	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	514					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTTTGTCCCTTGAGCCTCTCT	0.423													0	0	0	1	0	87	191										A	196198864	T	A	196198864	2	1	82	1	0	0	0	0	0	0	0	1	13459	1799	63	5		5	RNF168	3	196198864	Silent	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	3682347	196198864	1823566	118	24502										
PIGZ	80235	broad.mit.edu	37	chr3	196675332	196675332	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccccatcggcggggccaggtGgtacacggccccgtccagag	15	16	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:196675332G>A	uc003fxh.2	-	3	583	c.436C>T	c.(436-438)CAC>TAC	p.H146Y		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	146	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		GGGGCCAGGTGGTACACGGCC	0.667													0	0	0	1	0	13	24										A	196675332	G	A	196675332	3	1	82	1	0	0	0	0	1	0	0	0	11905	1348	47	2	1307	2	PIGZ	3	196675332	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	476468	196675332	1347098	119	24503										
LRCH3	84859	broad.mit.edu	37	chr3	197597072	197597072	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	catctgctgcacctaccactGattctacagattccataaca	4	14	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr3:197597072G>A	uc011bul.1	+	18	1920	c.1915G>A	c.(1915-1917)GAT>AAT	p.D639N	LRCH3_uc003fyj.1_Missense_Mutation_p.D639N|LRCH3_uc011bum.1_Missense_Mutation_p.D587N|LRCH3_uc011bun.1_Missense_Mutation_p.D485N|LRCH3_uc003fyk.2_Missense_Mutation_p.D234N	NM_032773	NP_116162	Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH)	639						extracellular region				ovary(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		ACCTACCACTGATTCTACAGA	0.403													0	0	0	1	0	47	84										A	197597072	G	A	197597072	3	1	82	1	0	0	0	0	1	0	0	0	8934	1290	45	1	1985	1	LRCH3	3	197597072	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	921740	197597072	425358	120	24504										
ZNF718	255403	broad.mit.edu	37	chr4	155410	155410	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgctggagagaaacccttctCatgcgaagaatgtggcaatg	12	8	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:155410C>T	uc003fzt.3	+	8	1068	c.935C>T	c.(934-936)TCA>TTA	p.S312L	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_Missense_Mutation_p.H92Y	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	312	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		AAACCCTTCTCATGCGAAGAA	0.388													0	0	0	1	0	10	17										T	155410	C	T	155410	3	4	82	1	0	0	0	0	1	0	0	0	18117	838	29	1	949	1	ZNF718	4	155410	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		155410	190998866	121	24505										
WHSC1	7468	broad.mit.edu	37	chr4	1932436	1932436	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agtctgctgagtgagaagcaGagagcacgctacaacaccaa	11	10	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:1932436G>A	uc003gdz.3	+	6	1670	c.1494G>A	c.(1492-1494)CAG>CAA	p.Q498Q	WHSC1_uc003geb.3_Silent_p.Q498Q|WHSC1_uc003gec.3_Silent_p.Q498Q|WHSC1_uc003ged.3_Silent_p.Q498Q|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdy.1_Silent_p.Q498Q|WHSC1_uc010icd.1_Silent_p.Q498Q|WHSC1_uc003gea.1_Silent_p.Q498Q|WHSC1_uc010ice.1_Silent_p.Q498Q|WHSC1_uc003geh.1_Silent_p.Q498Q	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	498	HMG box.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GTGAGAAGCAGAGAGCACGCT	0.537			T	IGH@	MM								0	0	0	1	0	17	28										A	1932436	G	A	1932436	2	1	82	1	0	0	0	0	0	0	0	1	17359	933	33	1		1	WHSC1	4	1932436	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1777026	1932436	189221840	122	24506										
POLN	353497	broad.mit.edu	37	chr4	2209868	2209868	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcaatgctcctgagttcccaGaatttaggtagccttcggcg	10	11	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:2209868G>A	uc003ger.2	-	3	560	c.560C>T	c.(559-561)TCT>TTT	p.S187F	POLN_uc010ich.1_5'UTR|POLN_uc011bvi.1_Missense_Mutation_p.S187F	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	187					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TGAGTTCCCAGAATTTAGGTA	0.368								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	33	54										A	2209868	G	A	2209868	3	1	82	1	0	0	0	0	1	0	0	0	12207	942	33	1	2230	1	POLN	4	2209868	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	277432	2209868	188944408	123	24507										
ADD1	118	broad.mit.edu	37	chr4	2900171	2900171	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcccctcaggttcttattctCcggaaccatgggctcgtgtc	9	14	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:2900171C>G	uc003gfr.2	+	8	1085	c.897C>G	c.(895-897)CTC>CTG	p.L299L	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Silent_p.L299L|ADD1_uc003gfo.2_Silent_p.L299L|ADD1_uc003gfp.2_Silent_p.L299L|ADD1_uc003gfq.2_Silent_p.L299L|ADD1_uc003gfs.2_Silent_p.L299L|ADD1_uc003gft.3_Silent_p.L299L|ADD1_uc003gfu.2_Silent_p.L84L	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	299					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTCTTATTCTCCGGAACCATG	0.493													0	0	0	1	0	57	94										G	2900171	C	G	2900171	2	3	82	1	0	0	0	0	0	0	0	1	304	842	30	1		1	ADD1	4	2900171	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	690303	2900171	188254105	124	24508										
CNO	55330	broad.mit.edu	37	chr4	6718478	6718478	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcacacgatgaacgtgccctCgctctttagcaagtctgctc	9	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:6718478C>G	uc003gjp.1	+	1	637	c.542C>G	c.(541-543)TCG>TGG	p.S181W		NM_018366	NP_060836	Q9NUP1	CNO_HUMAN	cappuccino	181					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol					0				Colorectal(103;0.0523)		AACGTGCCCTCGCTCTTTAGC	0.622													0	0	0	1	0	6	8										G	6718478	C	G	6718478	3	3	82	1	0	0	0	0	1	0	0	0	3616	893	31	1	544	1	CNO	4	6718478	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3818307	6718478	184435798	125	24509										
NKX3-2	579	broad.mit.edu	37	chr4	13543785	13543785	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcacctttacggccaccttCttggcggcgggcgccgaggc	14	15	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:13543785C>T	uc003gmx.2	-	2	910	c.834G>A	c.(832-834)AAG>AAA	p.K278K		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	278					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGGCCACCTTCTTGGCGGCGG	0.642													0	0	0	1	0	4	11										T	13543785	C	T	13543785	2	4	82	1	0	0	0	0	0	0	0	1	10456	912	32	1		1	NKX3-2	4	13543785	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6825307	13543785	177610491	126	24510										
PI4K2B	55300	broad.mit.edu	37	chr4	25253958	25253958	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcagtaactattggtacttCagagatgaatgcattcttgg	10	6	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:25253958C>A	uc003grk.2	+	2	417	c.284C>A	c.(283-285)TCA>TAA	p.S95*	PI4K2B_uc011bxs.1_5'UTR	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	95						cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				ATTGGTACTTCAGAGATGAAT	0.383													1	0	4.35082e-09	1	4.48012e-09	19	37										A	25253958	C	A	25253958	4	1	82	1	0	0	0	0	0	1	0	0	11872	838	29	3	290	3	PI4K2B	4	25253958	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	11710173	25253958	165900318	127	24511										
TXK	7294	broad.mit.edu	37	chr4	48096182	48096182	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taccactgtcctgagtcattCttttttatctgataatgttt	5	8	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:48096182C>T	uc003gxx.3	-	8	707	c.621G>A	c.(619-621)AAG>AAA	p.K207K	TXK_uc003gxy.1_Silent_p.K207K	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	207	SH2.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CTGAGTCATTCTTTTTTATCT	0.403													0	0	0	1	0	22	48										T	48096182	C	T	48096182	2	4	82	1	0	0	0	0	0	0	0	1	16783	912	32	1		1	TXK	4	48096182	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	22842224	48096182	143058094	128	24512										
FRYL	285527	broad.mit.edu	37	chr4	48517101	48517101	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	catctttcatctagctctttCagagctaaggtaacatcctc	5	12	5	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:48517101C>T	uc003gyh.1	-	56	8486	c.7881G>A	c.(7879-7881)CTG>CTA	p.L2627L	FRYL_uc003gyf.1_Silent_p.L23L|FRYL_uc003gyg.1_Silent_p.L1323L|FRYL_uc003gyi.1_Silent_p.L1515L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2627					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CTAGCTCTTTCAGAGCTAAGG	0.428													0	0	0	1	0	38	69										T	48517101	C	T	48517101	2	4	82	1	0	0	0	0	0	0	0	1	6064	813	29	1		1	FRYL	4	48517101	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	420919	48517101	142637175	129	24513										
CWH43	80157	broad.mit.edu	37	chr4	49052780	49052780	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagatggcaaaatttaggatCcctgatgaccccactaatta	7	10	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:49052780C>T	uc003gyv.2	+	15	2117	c.1935C>T	c.(1933-1935)ATC>ATT	p.I645I	CWH43_uc011bzl.1_Silent_p.I618I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	645					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						AATTTAGGATCCCTGATGACC	0.393													0	0	0	1	0	22	41										T	49052780	C	T	49052780	2	4	82	1	0	0	0	0	0	0	0	1	4073	845	30	1		1	CWH43	4	49052780	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	535679	49052780	142101496	130	24514										
LRRC66	339977	broad.mit.edu	37	chr4	52863983	52863983	+	Frame_Shift_Del	DEL	C	C	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aataaaattttgaaagactgCcacactatcatcacactgcc							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:52863983delC	uc003gzi.2	-	3	800	c.787delG	c.(787-789)GCAfs	p.A263fs		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	263						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TGAAAGACTGCCACACTATCA	0.398																		9	170	---	---								-	52863983	C	-	52863983	7	5	82	1	0	1	0	1	0	0	0	0	9018	739	26	0	1863	0	LRRC66	4	52863983	Frame_Shift_Del	DEL	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3811203	52863983	138290293	131	24515										
SCFD2	152579	broad.mit.edu	37	chr4	53786903	53786903	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tatacttgcctggtgggtatGatttccaggaacatatacag	10	7	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:53786903G>T	uc003gzu.2	-	6	1830	c.1696C>A	c.(1696-1698)CAT>AAT	p.H566N	SCFD2_uc010igm.2_Missense_Mutation_p.H566N	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	566					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TGGTGGGTATGATTTCCAGGA	0.393													1	0	1.1804e-14	1	1.23272e-14	25	33										T	53786903	G	T	53786903	3	4	82	1	0	0	0	0	1	0	0	0	13890	1290	45	3	374	3	SCFD2	4	53786903	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	922920	53786903	137367373	132	24516										
LNX1	84708	broad.mit.edu	37	chr4	54374161	54374161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	catttgactcacccctagttCggttgctccggccagagtcc	9	15	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:54374161C>T	uc003hag.3	-	3	870	c.614G>A	c.(613-615)CGA>CAA	p.R205Q	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Missense_Mutation_p.R109Q|LNX1_uc003hah.3_Intron	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	205						cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ACCCCTAGTTCGGTTGCTCCG	0.552													0	0	0	1	0	6	21										T	54374161	C	T	54374161	3	4	82	1	0	0	0	0	1	0	0	0	8865	884	31	1	1608	1	LNX1	4	54374161	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	587258	54374161	136780115	133	24517										
KIAA1211	57482	broad.mit.edu	37	chr4	57173841	57173841	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	attgtgactcagcaggacatCgtcctctcagacgcagagaa	10	11	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:57173841C>T	uc003hbk.2	+	5	652	c.261C>T	c.(259-261)ATC>ATT	p.I87I	KIAA1211_uc010iha.2_Silent_p.I80I|KIAA1211_uc011bzz.1_5'Flank|KIAA1211_uc003hbl.2_5'Flank|KIAA1211_uc003hbm.1_5'Flank	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	87										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					AGCAGGACATCGTCCTCTCAG	0.517													0	0	0	1	0	16	28										T	57173841	C	T	57173841	2	4	82	1	0	0	0	0	0	0	0	1	8215	874	31	1		1	KIAA1211	4	57173841	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2799680	57173841	133980435	134	24518										
TECRL	253017	broad.mit.edu	37	chr4	65194231	65194231	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agtgaaaaatgcttcttaccAcattctagctgcagaccaac	6	11	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:65194231A>G	uc003hcv.2	-	3	439	c.330T>C	c.(328-330)TGT>TGC	p.C110C	TECRL_uc003hcw.2_Silent_p.C110C	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	110					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						GCTTCTTACCACATTCTAGCT	0.299													0	0	0	1	0	19	40										G	65194231	A	G	65194231	2	3	82	1	0	0	0	0	0	0	0	1	15743	173	6	5		5	TECRL	4	65194231	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	8020390	65194231	125960045	135	24519										
ALB	213	broad.mit.edu	37	chr4	74277802	74277802	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcttaccaaagtccacacggAatgctgccatggagatctgc	9	12	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:74277802A>T	uc003hgs.3	+	7	876	c.803A>T	c.(802-804)GAA>GTA	p.E268V	ALB_uc003hgw.3_Missense_Mutation_p.E76V|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Missense_Mutation_p.E268V|ALB_uc010iii.2_Missense_Mutation_p.E153V|ALB_uc003hgu.3_Missense_Mutation_p.E118V|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Missense_Mutation_p.E158V|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	268	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GTCCACACGGAATGCTGCCAT	0.458													0	0	0	1	0	32	62										T	74277802	A	T	74277802	3	4	82	1	0	0	0	0	1	0	0	0	486	246	9	5	829	5	ALB	4	74277802	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	9083571	74277802	116876474	136	24520										
RASSF6	166824	broad.mit.edu	37	chr4	74453627	74453627	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcactaatacgatagagatcGtcaaattccccccagcgtgt	7	12	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:74453627G>A	uc003hhd.1	-	5	531	c.408C>T	c.(406-408)GAC>GAT	p.D136D	RASSF6_uc003hhc.1_Silent_p.D104D|RASSF6_uc010iik.1_Silent_p.D104D|RASSF6_uc010iil.1_Silent_p.D92D	NM_201431	NP_958834	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family 6	136					apoptosis|signal transduction		protein binding			pancreas(2)	2	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GATAGAGATCGTCAAATTCCC	0.383													0	0	0	1	0	19	42										A	74453627	G	A	74453627	2	1	82	1	0	0	0	0	0	0	0	1	13090	1136	40	2		2	RASSF6	4	74453627	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	175825	74453627	116700649	137	24521										
ANKRD56	345079	broad.mit.edu	37	chr4	77818388	77818388	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agctctcccggcagtacagcCaggttgttctggaggcattc	12	12	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:77818388C>T	uc003hki.2	-	1	615	c.615G>A	c.(613-615)CTG>CTA	p.L205L		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	205	Ala-rich.										0						GCAGTACAGCCAGGTTGTTCT	0.731													0	0	0	1	0	4	4										T	77818388	C	T	77818388	2	4	82	1	0	0	0	0	0	0	0	1	682	581	21	2		2	ANKRD56	4	77818388	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3364761	77818388	113335888	138	24522										
FRAS1	80144	broad.mit.edu	37	chr4	79434557	79434557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tccccctagaatccacatttCggtgcagatcccacaccagg	7	16	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:79434557C>T	uc003hlb.2	+	65	10465	c.10025C>T	c.(10024-10026)TCG>TTG	p.S3342L		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3337	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ATCCACATTTCGGTGCAGATC	0.433													0	0	0	1	0	46	61										T	79434557	C	T	79434557	3	4	82	1	0	0	0	0	1	0	0	0	6042	893	31	1	10358	1	FRAS1	4	79434557	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1616169	79434557	111719719	139	24523										
FGF5	2250	broad.mit.edu	37	chr4	81207685	81207685	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgccaagattcaagcagtcGgagcagccagaactttcttt	9	11	2	2	rs3733335		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:81207685G>A	uc003hmd.2	+	3	903	c.666G>A	c.(664-666)TCG>TCA	p.S222S	FGF5_uc003hme.2_3'UTR	NM_004464	NP_004455	P12034	FGF5_HUMAN	fibroblast growth factor 5 isoform 1 precursor	222					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			ovary(1)|breast(1)	2						TCAAGCAGTCGGAGCAGCCAG	0.478													0	0	0	1	0	45	52										A	81207685	G	A	81207685	2	1	82	1	0	0	0	0	0	0	0	1	5855	1103	39	2		2	FGF5	4	81207685	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1773128	81207685	109946591	140	24524										
HELQ	113510	broad.mit.edu	37	chr4	84350762	84350762	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taaatagtgtctttttgtagGagtcctttttctgtcaggta	9	5	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:84350762G>A	uc003hom.2	-	12	2612	c.2433C>T	c.(2431-2433)CTC>CTT	p.L811L	HELQ_uc010ikb.2_Silent_p.L744L|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	811							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						CTTTTTGTAGGAGTCCTTTTT	0.328								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	1	0	20	32										A	84350762	G	A	84350762	2	1	82	1	0	0	0	0	0	0	0	1	7047	1161	41	1		1	HELQ	4	84350762	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3143077	84350762	106803514	141	24525										
C4orf33	132321	broad.mit.edu	37	chr4	130023826	130023826	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgaagcatgagcccgtatttAtcaggctgaatccaggtgac	11	9	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:130023826A>G	uc003igu.3	+	2	425	c.61A>G	c.(61-63)ATC>GTC	p.I21V	C4orf33_uc010ioc.1_Missense_Mutation_p.I21V|C4orf33_uc010iod.2_Missense_Mutation_p.I21V	NM_173487	NP_775758	Q8N1A6	CD033_HUMAN	hypothetical protein LOC132321	21										upper_aerodigestive_tract(1)	1						GCCCGTATTTATCAGGCTGAA	0.408													0	0	0	1	0	33	80										G	130023826	A	G	130023826	3	3	82	1	0	0	0	0	1	0	0	0	2263	449	16	5	63	5	C4orf33	4	130023826	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	45673064	130023826	61130450	142	24526										
ACCN5	51802	broad.mit.edu	37	chr4	156784856	156784856	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaacttctttcgctcagtggGagatggcagtggtttctttg	12	7	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:156784856G>C	uc003ipe.1	-	2	138	c.91C>G	c.(91-93)CCC>GCC	p.P31A		NM_017419	NP_059115	Q9NY37	ACCN5_HUMAN	amiloride-sensitive cation channel 5,	31	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0464)|Kidney(143;0.058)|COAD - Colon adenocarcinoma(41;0.141)		CGCTCAGTGGGAGATGGCAGT	0.388													0	0	0	1	0	52	47										C	156784856	G	C	156784856	3	2	82	1	0	0	0	0	1	0	0	0	132	1174	41	1	1462	1	ACCN5	4	156784856	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	26761030	156784856	34369420	143	24527										
ANP32C	23520	broad.mit.edu	37	chr4	165118255	165118255	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taaccttcttcatcctcctcGtcccctccactcacgtcctc	2	21	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:165118255G>A	uc011cjk.1	-	1	609	c.609C>T	c.(607-609)GAC>GAT	p.D203D	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	203	Asp/Glu-rich (highly acidic).										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		catcctcctcgtcccctccac	0.085													0	0	0	1	0	4	11										A	165118255	G	A	165118255	2	1	82	1	0	0	0	0	0	0	0	1	707	1136	40	2		2	ANP32C	4	165118255	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	8333399	165118255	26036021	144	24528										
ODZ3	55714	broad.mit.edu	37	chr4	183267920	183267920	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	actctatcagtgcagggtcaGatgctgatactgaaaatgaa	10	7	3	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr4:183267920G>A	uc003ivd.1	+	2	386	c.349G>A	c.(349-351)GAT>AAT	p.D117N	ODZ3_uc010irv.1_Missense_Mutation_p.D117N	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	117	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGCAGGGTCAGATGCTGATAC	0.532													0	0	0	1	0	4	6										A	183267920	G	A	183267920	3	1	82	1	0	0	0	0	1	0	0	0	10836	942	33	1	355	1	ODZ3	4	183267920	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	18149665	183267920	7886356	145	24529										
ZNF622	90441	broad.mit.edu	37	chr5	16458679	16458679	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	catattccaagttcttttctGagggcaactcctcagcctta	6	12	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:16458679G>A	uc003jfq.2	-	4	1229	c.1109C>T	c.(1108-1110)TCA>TTA	p.S370L		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	370						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						GTTCTTTTCTGAGGGCAACTC	0.393													0	0	0	1	0	14	48										A	16458679	G	A	16458679	3	1	82	1	0	0	0	0	1	0	0	0	18043	1294	45	1	336	1	ZNF622	5	16458679	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		16458679	164456581	146	24530										
LIFR	3977	broad.mit.edu	37	chr5	38481864	38481864	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtctatggatctaggagagtCtggagacactaaattccatg	11	7	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:38481864C>T	uc010ive.1	-	20	3459	c.3127G>A	c.(3127-3129)GAC>AAC	p.D1043N	LIFR_uc003jli.2_Missense_Mutation_p.D1043N	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	1043	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					CTAGGAGAGTCTGGAGACACT	0.403			T	PLAG1	salivary adenoma								0	0	0	1	0	49	89										T	38481864	C	T	38481864	3	4	82	1	0	0	0	0	1	0	0	0	8780	913	32	1	170	1	LIFR	5	38481864	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	22023185	38481864	142433396	147	24531										
TTC33	23548	broad.mit.edu	37	chr5	40716332	40716332	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tctctatggccccagaagcaGacacaataaccattgtttta	6	11	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:40716332G>A	uc003jma.2	-	5	852	c.704C>T	c.(703-705)TCT>TTT	p.S235F	TTC33_uc011cpm.1_Missense_Mutation_p.S127F|TTC33_uc010ivg.2_3'UTR	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	235							binding			ovary(1)	1						CCCAGAAGCAGACACAATAAC	0.428													0	0	0	1	0	24	42										A	40716332	G	A	40716332	3	1	82	1	0	0	0	0	1	0	0	0	16699	942	33	1	88	1	TTC33	5	40716332	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2234468	40716332	140198928	148	24532										
PELO	53918	broad.mit.edu	37	chr5	52096666	52096666	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtggtcatgcaggaaggcctCgcccatatctgcttagtcac	11	12	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:52096666C>T	uc003jos.2	+	2	1423	c.438C>T	c.(436-438)CTC>CTT	p.L146L	ITGA1_uc003jov.2_Intron|ITGA1_uc003jou.2_Intron|PELO_uc003jot.1_Intron	NM_015946	NP_057030	Q9BRX2	PELO_HUMAN	pelota homolog	146					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding				0		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				AGGAAGGCCTCGCCCATATCT	0.582													0	0	0	1	0	21	24										T	52096666	C	T	52096666	2	4	82	1	0	0	0	0	0	0	0	1	11724	871	31	1		1	PELO	5	52096666	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	11380334	52096666	128818594	149	24533										
PPAP2A	8611	broad.mit.edu	37	chr5	54721068	54721070	+	In_Frame_Del	DEL	GTT	GTT	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgctcggatagtgattcccaGttgttggtgtttcatgcaga							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:54721068_54721070delGTT	uc003jqa.2	-	6	1235_1237	c.819_821delAAC	c.(817-822)ACAACT>ACT	p.273_274TT>T	SKIV2L2_uc003jpy.3_3'UTR|SKIV2L2_uc011cqi.1_3'UTR|PPAP2A_uc003jpz.2_In_Frame_Del_p.274_275TT>T|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	273_274	Cytoplasmic (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GTGATTCCCAGTTGTTGGTGTTT	0.438																		30	44	---	---								-	54721070	GTT	-	54721068	7	5	82	1	0	1	0	1	0	0	0	0	12290	1029	36	0	37	0	PPAP2A	5	54721068	In_Frame_Del	DEL	GTT	TCGA-FD-A3SN-01A-12D-A22Z-08	2624402	54721068	126194192	150	24534										
SLC38A9	153129	broad.mit.edu	37	chr5	54929659	54929659	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagagtgggtatacagtcatCatctggaacagcaggaatat	11	6	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:54929659C>T	uc003jqf.2	-	14	1554	c.1353G>A	c.(1351-1353)ATG>ATA	p.M451I	SLC38A9_uc003jqd.2_Missense_Mutation_p.M388I|SLC38A9_uc010ivx.2_Missense_Mutation_p.M388I|SLC38A9_uc003jqe.2_Intron|SLC38A9_uc010ivy.2_Missense_Mutation_p.M322I	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	451	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				ATACAGTCATCATCTGGAACA	0.448													0	0	0	1	0	15	25										T	54929659	C	T	54929659	3	4	82	1	0	0	0	0	1	0	0	0	14611	826	29	1	344	1	SLC38A9	5	54929659	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	208591	54929659	125985601	151	24535										
CMYA5	202333	broad.mit.edu	37	chr5	79025761	79025761	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acacctgcaactatgttcctGagaacaacaaaggaagaatg	8	9	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:79025761G>A	uc003kgc.2	+	2	1245	c.1173G>A	c.(1171-1173)CTG>CTA	p.L391L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	391						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTATGTTCCTGAGAACAACAA	0.468													0	0	0	1	0	16	9										A	79025761	G	A	79025761	2	1	82	1	0	0	0	0	0	0	0	1	3590	1277	45	1		1	CMYA5	5	79025761	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	24096102	79025761	101889499	152	24536										
SRP19	6728	broad.mit.edu	37	chr5	112200214	112200214	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gttcagcagttggacttaacGtatttcttgaggtatgacgt	11	6	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:112200214G>A	uc003kqc.2	+	3	259	c.178G>A	c.(178-180)GTA>ATA	p.V60I	SRP19_uc003kqb.1_Missense_Mutation_p.V60I|SRP19_uc011cvu.1_5'UTR|SRP19_uc011cvv.1_Silent_p.T9T	NM_003135	NP_003126	P09132	SRP19_HUMAN	signal recognition particle 19kDa	60					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		TGGACTTAACGTATTTCTTGA	0.323													0	0	0	1	0	20	21										A	112200214	G	A	112200214	3	1	82	1	0	0	0	0	1	0	0	0	15153	1145	40	2	188	2	SRP19	5	112200214	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	33174453	112200214	68715046	153	24537										
DTWD2	285605	broad.mit.edu	37	chr5	118274974	118274974	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agtagaggaactgtacgcaaCactttgttttcctttaatta	7	7	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:118274974C>T	uc003ksa.2	-	3	355	c.321G>A	c.(319-321)GTG>GTA	p.V107V		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	DTW domain containing 2	107											0		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		CTGTACGCAACACTTTGTTTT	0.333													0	0	0	1	0	11	4										T	118274974	C	T	118274974	2	4	82	1	0	0	0	0	0	0	0	1	4792	465	17	2		2	DTWD2	5	118274974	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6074760	118274974	62640286	154	24538										
LMNB1	4001	broad.mit.edu	37	chr5	126113516	126113516	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcgcgccaagctgcagatcGagctgggcaagtgcaaggcg	16	11	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:126113516G>A	uc003kud.1	+	1	684	c.316G>A	c.(316-318)GAG>AAG	p.E106K	LMNB1_uc003kuc.2_Missense_Mutation_p.E106K|LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Intron	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	106	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		GCTGCAGATCGAGCTGGGCAA	0.711													0	0	0	1	0	2	0										A	126113516	G	A	126113516	3	1	82	1	0	0	0	0	1	0	0	0	8849	1059	37	1	318	1	LMNB1	5	126113516	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7838542	126113516	54801744	155	24539										
FBN2	2201	broad.mit.edu	37	chr5	127685049	127685049	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgaatcttacccaaacatacAcggccagtcccatccaacgt	5	15	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:127685049A>G	uc003kuu.2	-	23	3418	c.2979T>C	c.(2977-2979)CGT>CGC	p.R993R	FBN2_uc003kuv.2_Silent_p.R960R	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	993	EGF-like 14; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCAAACATACACGGCCAGTCC	0.453													0	0	0	1	0	8	6										G	127685049	A	G	127685049	2	3	82	1	0	0	0	0	0	0	0	1	5703	146	6	5		5	FBN2	5	127685049	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	1571533	127685049	53230211	156	24540										
SPINK5	11005	broad.mit.edu	37	chr5	147449958	147449958	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cccaggataagaaattttttCaaagtcttgatggaataatg	8	5	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:147449958C>G	uc003lox.2	+	3	227	c.154C>G	c.(154-156)CAA>GAA	p.Q52E	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.Q24E|SPINK5_uc010jgr.2_Missense_Mutation_p.Q33E|SPINK5_uc003low.2_Missense_Mutation_p.Q52E|SPINK5_uc003loy.2_Missense_Mutation_p.Q52E	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	52	Kazal-like 1; atypical.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAATTTTTTCAAAGTCTTGA	0.328													0	0	0	1	0	28	22										G	147449958	C	G	147449958	3	3	82	1	0	0	0	0	1	0	0	0	15061	827	29	1	164	1	SPINK5	5	147449958	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	19764909	147449958	33465302	157	24541										
SPINK5	11005	broad.mit.edu	37	chr5	147499895	147499895	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaaaaaaaaagaaagaggatGaagacaggagcaatacagga	11	3	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:147499895G>A	uc003lox.2	+	26	2552	c.2479G>A	c.(2479-2481)GAA>AAA	p.E827K	SPINK5_uc010jgr.2_Missense_Mutation_p.E808K|SPINK5_uc003low.2_Missense_Mutation_p.E827K|SPINK5_uc003loy.2_Missense_Mutation_p.E827K	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	827	Kazal-like 12.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAGAGGATGAAGACAGGAG	0.393													0	0	0	1	0	7	7										A	147499895	G	A	147499895	3	1	82	1	0	0	0	0	1	0	0	0	15061	1291	45	1	2581	1	SPINK5	5	147499895	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	49937	147499895	33415365	158	24542										
CSNK1A1	1452	broad.mit.edu	37	chr5	148930407	148930407	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cccaccccagatgattacctCgccgttggtgatgttgatcg	10	13	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:148930407C>T	uc003lqx.1	-	1	601	c.121G>A	c.(121-123)GAG>AAG	p.E41K	CSNK1A1_uc011dcc.1_5'Flank|CSNK1A1_uc003lqv.1_5'Flank|CSNK1A1_uc003lqw.1_Missense_Mutation_p.E41K|CSNK1A1_uc003lqy.1_Missense_Mutation_p.E41K|CSNK1A1_uc010jha.1_Missense_Mutation_p.E41K	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	41	Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		ATGATTACCTCGCCGTTGGTG	0.547													0	0	0	1	0	25	17										T	148930407	C	T	148930407	3	4	82	1	0	0	0	0	1	0	0	0	3950	893	31	1	1020	1	CSNK1A1	5	148930407	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1430512	148930407	31984853	159	24543										
G3BP1	10146	broad.mit.edu	37	chr5	151179821	151179822	+	Frame_Shift_Ins	INS	-	-	GGTGG													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gacattgaaccccgaagaatINSggtgagacaccctgacagtc							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:151179821_151179822insGGTGG	uc003lun.2	+	10	1169_1170	c.998_999insGGTGG	c.(997-999)ATGfs	p.M333fs	G3BP1_uc003lum.2_Frame_Shift_Ins_p.M333fs|G3BP1_uc011dcu.1_Frame_Shift_Ins_p.M151fs|G3BP1_uc010jhz.2_Frame_Shift_Ins_p.M151fs|G3BP1_uc003luq.2_Frame_Shift_Ins_p.M1fs	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	333					Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			CCCCGAAGAATGGTGAGACACC	0.416																		14	24	---	---								GGTGG	151179822	-	GGTGG	151179821	7	5	82	1	0	1	1	0	0	0	0	0	6141	1464	51	0	1032	0	G3BP1	5	151179821	Frame_Shift_Ins	INS	-	TCGA-FD-A3SN-01A-12D-A22Z-08	2249414	151179821	29735439	160	24544										
SNCB	6620	broad.mit.edu	37	chr5	176053748	176053748	+	Missense_Mutation	SNP	C	C	T													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cacaccttgtaccacaccttCtcgggtcttgcttcctgcag							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:176053748C>T	uc003mep.2	-	4	579	c.136G>A	c.(136-138)GAA>AAA	p.E46K	SNCB_uc003meq.2_Missense_Mutation_p.E46K|SNCB_uc010jke.1_Missense_Mutation_p.E46K	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	46	3; approximate.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCACACCTTCTCGGGTCTTG	0.577													0	0	0	1	0	31	22										T	176053748	C	T	176053748	3	4	82	1	0	0	0	0	1	0	0	0	14842	922	32	1	284	1	SNCB	5	176053748	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	24873927	176053748	4861512	161	24545	124	2								
SNCB	6620	broad.mit.edu	37	chr5	176053750	176053750	+	Missense_Mutation	SNP	C	C	T													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	caccttgtaccacaccttctCgggtcttgcttcctgcaggg							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr5:176053750C>T	uc003mep.2	-	4	577	c.134G>A	c.(133-135)CGA>CAA	p.R45Q	SNCB_uc003meq.2_Missense_Mutation_p.R45Q|SNCB_uc010jke.1_Missense_Mutation_p.R45Q	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	45	3; approximate.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACACCTTCTCGGGTCTTGCT	0.572													0	0	0	1	0	31	22										T	176053750	C	T	176053750	3	4	82	1	0	0	0	0	1	0	0	0	14842	884	31	1	286	1	SNCB	5	176053750	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2	176053750	4861510	162	24546	124	2								
RREB1	6239	broad.mit.edu	37	chr6	7182305	7182305	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggaccaaatcggattggcaGaaggaaccaggtaagtgttc	13	7	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:7182305G>A	uc003mxc.2	+	4	551	c.161G>A	c.(160-162)AGA>AAA	p.R54K	RREB1_uc010jnw.2_Missense_Mutation_p.R54K|RREB1_uc003mxb.2_Missense_Mutation_p.R54K|RREB1_uc010jnx.2_Missense_Mutation_p.R54K|RREB1_uc003mxd.2_Missense_Mutation_p.R54K	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	54					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CGGATTGGCAGAAGGAACCAG	0.527													0	0	0	1	0	23	15										A	7182305	G	A	7182305	3	1	82	1	0	0	0	0	1	0	0	0	13679	942	33	1	163	1	RREB1	6	7182305	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		7182305	163932762	163	24547										
DSP	1832	broad.mit.edu	37	chr6	7542296	7542296	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctcggcgcggcgtgatcaccGaccagaactcggacggctac	13	15	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:7542296G>A	uc003mxp.1	+	1	427	c.148G>A	c.(148-150)GAC>AAC	p.D50N	DSP_uc003mxq.1_Missense_Mutation_p.D50N	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	50	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CGTGATCACCGACCAGAACTC	0.701													0	0	0	1	0	2	1										A	7542296	G	A	7542296	3	1	82	1	0	0	0	0	1	0	0	0	4781	1058	37	1	150	1	DSP	6	7542296	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	359991	7542296	163572771	164	24548										
BMP6	654	broad.mit.edu	37	chr6	7880494	7880494	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aactaagctaaatgccatctCggttctttactttgatgaca	6	9	2	2	rs139361183		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:7880494C>T	uc003mxu.3	+	7	1638	c.1460C>T	c.(1459-1461)TCG>TTG	p.S487L		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	487					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					AATGCCATCTCGGTTCTTTAC	0.448													0	0	0	1	0	56	53										T	7880494	C	T	7880494	3	4	82	1	0	0	0	0	1	0	0	0	1464	893	31	1	1486	1	BMP6	6	7880494	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	338198	7880494	163234573	165	24549										
HIST1H1B	3009	broad.mit.edu	37	chr6	27835260	27835260	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttcttcttagccggggatttCtccaccggcgctggggtggc	14	12	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:27835260C>T	uc003njx.2	-	1	100	c.48G>A	c.(46-48)GAG>GAA	p.E16E		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	16					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CCGGGGATTTCTCCACCGGCG	0.582													0	0	0	1	0	26	11										T	27835260	C	T	27835260	2	4	82	1	0	0	0	0	0	0	0	1	7123	912	32	1		1	HIST1H1B	6	27835260	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	19954766	27835260	143279807	166	24550										
GNL1	2794	broad.mit.edu	37	chr6	30523426	30523426	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agactccccgtccgaggtgtCggtctgttcctctcgccgct	11	16	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:30523426C>T	uc003nqh.2	-	2	1173	c.145G>A	c.(145-147)GAC>AAC	p.D49N	GNL1_uc011dmi.1_5'UTR|GNL1_uc011dmj.1_Missense_Mutation_p.D47N|GNL1_uc011dmk.1_Intron|PRR3_uc003nqi.1_5'Flank|PRR3_uc003nqj.1_5'Flank	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	49					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						TCCGAGGTGTCGGTCTGTTCC	0.662													0	0	0	1	0	19	17										T	30523426	C	T	30523426	3	4	82	1	0	0	0	0	1	0	0	0	6535	884	31	1	1722	1	GNL1	6	30523426	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2688166	30523426	140591641	167	24551										
HLA-C	3107	broad.mit.edu	37	chr6	31239458	31239458	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggcgcttgtacttctgtgtCtcccggtcccaatactccgg	10	14	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31239458C>T	uc003nsy.2	-	2	268	c.261G>A	c.(259-261)GAG>GAA	p.E87E	HLA-C_uc011dnj.1_Silent_p.E59E|HLA-C_uc003nsx.2_5'UTR|HLA-C_uc003nsz.2_Silent_p.E87E|HLA-C_uc010jsl.2_Silent_p.E87E|HLA-C_uc003nta.2_Silent_p.E87E|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_5'UTR|HLA-B_uc003ntf.2_Intron	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	87	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						ACTTCTGTGTCTCCCGGTCCC	0.687													0	0	0	1	0	16	14										T	31239458	C	T	31239458	2	4	82	1	0	0	0	0	0	0	0	1	7197	912	32	1		1	HLA-C	6	31239458	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	716032	31239458	139875609	168	24552										
DDAH2	23564	broad.mit.edu	37	chr6	31695035	31695035	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagctgtgggggcgtgtgctGagcaccaagcagagggagct	18	9	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31695035G>A	uc003nwp.2	-	6	1468	c.837C>T	c.(835-837)CTC>CTT	p.L279L	DDAH2_uc003nwq.2_Silent_p.L279L	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	279					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	GGCGTGTGCTGAGCACCAAGC	0.592													0	0	0	1	0	50	53										A	31695035	G	A	31695035	2	1	82	1	0	0	0	0	0	0	0	1	4322	1277	45	1		1	DDAH2	6	31695035	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	455577	31695035	139420032	169	24553										
SLC44A4	80736	broad.mit.edu	37	chr6	31842778	31842778	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gacaggatgcagctgaagatGttgaagtacaggagatacgg	15	5	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31842778G>A	uc010jti.2	-	5	336	c.270C>T	c.(268-270)AAC>AAT	p.N90N	SLC44A4_uc011dol.1_Silent_p.N14N|SLC44A4_uc011dom.1_Silent_p.N90N	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	90	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	AGCTGAAGATGTTGAAGTACA	0.597													0	0	0	1	0	44	27										A	31842778	G	A	31842778	2	1	82	1	0	0	0	0	0	0	0	1	14638	1368	48	2		2	SLC44A4	6	31842778	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	147743	31842778	139272289	170	24554										
EHMT2	10919	broad.mit.edu	37	chr6	31864542	31864542	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gccagcaggctccagggagtCgggggtggccttgggcaggg	21	10	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:31864542C>T	uc003nxz.1	-	3	179	c.169G>A	c.(169-171)GAC>AAC	p.D57N	EHMT2_uc003nxy.1_5'UTR|EHMT2_uc011don.1_Missense_Mutation_p.D114N|EHMT2_uc003nya.1_Missense_Mutation_p.D57N|EHMT2_uc003nyb.1_Missense_Mutation_p.D57N|C2_uc003nyc.2_5'Flank|C2_uc011doo.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	57					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TCCAGGGAGTCGGGGGTGGCC	0.582													0	0	0	1	0	30	21										T	31864542	C	T	31864542	3	4	82	1	0	0	0	0	1	0	0	0	4984	884	31	1	3567	1	EHMT2	6	31864542	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	21764	31864542	139250525	171	24555										
RXRB	6257	broad.mit.edu	37	chr6	33162525	33162525	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcgatgggggtgtcaccaatGagcttgaagaaaaacagatg	13	6	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:33162525G>A	uc003odb.2	-	10	1715	c.1536C>T	c.(1534-1536)CTC>CTT	p.L512L	RXRB_uc003odc.2_Silent_p.L516L|RXRB_uc003odd.2_Silent_p.L416L|RXRB_uc011dqr.1_Silent_p.L326L	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	512	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TGTCACCAATGAGCTTGAAGA	0.557													0	0	0	1	0	16	13										A	33162525	G	A	33162525	2	1	82	1	0	0	0	0	0	0	0	1	13764	1277	45	1		1	RXRB	6	33162525	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1297983	33162525	137952542	172	24556										
C6orf89	221477	broad.mit.edu	37	chr6	36882094	36882094	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggacaaacgactgtgagcaGaatgagtcagagcccattcc	11	10	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:36882094G>A	uc003omx.2	+	5	722	c.438G>A	c.(436-438)CAG>CAA	p.Q146Q	C6orf89_uc003omv.2_Silent_p.Q40Q|C6orf89_uc003omw.2_Silent_p.Q153Q|C6orf89_uc011dtr.1_Silent_p.Q40Q|C6orf89_uc003omy.2_5'UTR	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	146						integral to membrane				ovary(1)	1						ACTGTGAGCAGAATGAGTCAG	0.517													0	0	0	1	0	21	21										A	36882094	G	A	36882094	2	1	82	1	0	0	0	0	0	0	0	1	2373	933	33	1		1	C6orf89	6	36882094	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3719569	36882094	134232973	173	24557										
CCND3	896	broad.mit.edu	37	chr6	41903779	41903779	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgctgggctggagctggtctGagaggcttccctgaggctct	16	11	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:41903779G>A	uc003orn.2	-	5	943	c.778C>T	c.(778-780)CAG>TAG	p.Q260*	CCND3_uc003orp.2_Nonsense_Mutation_p.Q179*|CCND3_uc011duk.1_Nonsense_Mutation_p.Q64*|CCND3_uc003orm.2_Nonsense_Mutation_p.Q210*|CCND3_uc003oro.2_Nonsense_Mutation_p.Q188*	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	260					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GAGCTGGTCTGAGAGGCTTCC	0.627			T	IGH@	MM								0	0	0	1	0	6	3										A	41903779	G	A	41903779	4	1	82	1	0	0	0	0	0	1	0	0	2918	1299	45	1	104	1	CCND3	6	41903779	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	5021685	41903779	129211288	174	24558										
HMGCLL1	54511	broad.mit.edu	37	chr6	55304265	55304265	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggccattaagcatatatatCaaatcctcagtggctacatt	6	9	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:55304265C>G	uc003pcn.2	-	9	1137	c.978G>C	c.(976-978)TTG>TTC	p.L326F	HMGCLL1_uc003pco.2_Missense_Mutation_p.L296F|HMGCLL1_uc010jzx.2_Missense_Mutation_p.L197F|HMGCLL1_uc011dxc.1_Missense_Mutation_p.L264F|HMGCLL1_uc011dxd.1_Missense_Mutation_p.L193F|HMGCLL1_uc011dxe.1_Missense_Mutation_p.L130F	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	326							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCATATATATCAAATCCTCAG	0.418													0	0	0	1	0	30	22										G	55304265	C	G	55304265	3	3	82	1	0	0	0	0	1	0	0	0	7230	825	29	1	142	1	HMGCLL1	6	55304265	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	13400486	55304265	115810802	175	24559										
COL9A1	1297	broad.mit.edu	37	chr6	70944596	70944596	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccttccactccaggaagcccCcgacttccctcaggccctct	6	21	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:70944596C>T	uc003pfg.3	-	34	2319	c.2160G>A	c.(2158-2160)CGG>CGA	p.R720R	COL9A1_uc003pfe.3_Silent_p.R269R|COL9A1_uc003pff.3_Silent_p.R477R	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	720	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CAGGAAGCCCCCGACTTCCCT	0.612													0	0	0	1	0	13	11										T	70944596	C	T	70944596	2	4	82	1	0	0	0	0	0	0	0	1	3707	610	22	2		2	COL9A1	6	70944596	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	15640331	70944596	100170471	176	24560										
LACE1	246269	broad.mit.edu	37	chr6	108676919	108676919	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtggaaatgaagaggaaaaaAcgggttcattttcatggttt	12	3	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:108676919A>G	uc003psj.2	+	4	663	c.477A>G	c.(475-477)AAA>AAG	p.K159K		NM_145315	NP_660358	Q8WV93	LACE1_HUMAN	lactation elevated 1	159							ATP binding			central_nervous_system(1)	1		all_cancers(87;1.5e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;6.79e-05)|Colorectal(196;0.0294)|all_lung(197;0.0486)|Lung SC(18;0.152)		BRCA - Breast invasive adenocarcinoma(108;0.00179)|Epithelial(106;0.0024)|all cancers(137;0.00379)|OV - Ovarian serous cystadenocarcinoma(136;0.0118)		AGAGGAAAAAACGGGTTCATT	0.303													0	0	0	1	0	34	16										G	108676919	A	G	108676919	2	3	82	1	0	0	0	0	0	0	0	1	8595	40	2	5		5	LACE1	6	108676919	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	37732323	108676919	62438148	177	24561										
TRAF3IP2	10758	broad.mit.edu	37	chr6	111912967	111912967	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgctgactgcagagcacccaGaagggaaagctttgcccagg	13	12	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:111912967G>A	uc011ebc.1	-	3	938	c.323C>T	c.(322-324)TCT>TTT	p.S108F	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.S108F|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.S108F|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.S108F|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.S108F	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	117					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		AGAGCACCCAGAAGGGAAAGC	0.552													0	0	0	1	0	20	17										A	111912967	G	A	111912967	3	1	82	1	0	0	0	0	1	0	0	0	16438	942	33	1	1406	1	TRAF3IP2	6	111912967	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3236048	111912967	59202100	178	24562										
LAMA4	3910	broad.mit.edu	37	chr6	112466047	112466047	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agctctcggatcctctggatGctggcagaaacgttgcttgc	12	11	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:112466047G>A	uc003pvu.2	-	19	2751	c.2442C>T	c.(2440-2442)AGC>AGT	p.S814S	LAMA4_uc003pvv.2_Silent_p.S807S|LAMA4_uc003pvt.2_Silent_p.S807S	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	814	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TCCTCTGGATGCTGGCAGAAA	0.488													0	0	0	1	0	30	12										A	112466047	G	A	112466047	2	1	82	1	0	0	0	0	0	0	0	1	8608	1310	46	2		2	LAMA4	6	112466047	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	553080	112466047	58649020	179	24563										
LAMA2	3908	broad.mit.edu	37	chr6	129826498	129826498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acactacccgaagaattggtCcagtaaatatctgatttctt	6	9	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:129826498C>T	uc003qbn.2	+	60	8806	c.8701C>T	c.(8701-8703)CCA>TCA	p.P2901S	LAMA2_uc003qbo.2_Missense_Mutation_p.P2897S|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2901	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAGAATTGGTCCAGTAAATAT	0.383													0	0	0	1	0	28	10										T	129826498	C	T	129826498	3	4	82	1	0	0	0	0	1	0	0	0	8606	855	30	1	8943	1	LAMA2	6	129826498	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	17360451	129826498	41288569	180	24564										
REPS1	85021	broad.mit.edu	37	chr6	139265753	139265753	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	accacactgcatcaccagcaGaagaacctataaggagaatg	8	11	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:139265753G>A	uc003qii.2	-	5	1214	c.635C>T	c.(634-636)TCT>TTT	p.S212F	REPS1_uc003qig.3_Missense_Mutation_p.S212F|REPS1_uc011edr.1_Missense_Mutation_p.S212F|REPS1_uc003qij.2_Missense_Mutation_p.S212F|REPS1_uc003qik.2_Intron	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	212						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		ATCACCAGCAGAAGAACCTAT	0.428													0	0	0	1	0	22	28										A	139265753	G	A	139265753	3	1	82	1	0	0	0	0	1	0	0	0	13228	942	33	1	1819	1	REPS1	6	139265753	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	9439255	139265753	31849314	181	24565										
THBS2	7058	broad.mit.edu	37	chr6	169648584	169648584	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tccgcctgcaggtgctcgtaGaagggctcgtccagagcgaa	14	12	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr6:169648584G>A	uc003qwt.2	-	4	785	c.537C>T	c.(535-537)TTC>TTT	p.F179F		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	179	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGTGCTCGTAGAAGGGCTCGT	0.617													0	0	0	1	0	39	36										A	169648584	G	A	169648584	2	1	82	1	0	0	0	0	0	0	0	1	15851	933	33	1		1	THBS2	6	169648584	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	30382831	169648584	1466483	182	24566										
MAFK	7975	broad.mit.edu	37	chr7	1579901	1579901	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcagaccttcgcgcgcaccGtggcccggggacctgtggcg	16	15	0	1	rs143840628		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:1579901G>A	uc003skr.2	+	3	572	c.361G>A	c.(361-363)GTG>ATG	p.V121M	MAFK_uc003sks.1_RNA	NM_002360	NP_002351	O60675	MAFK_HUMAN	v-maf musculoaponeurotic fibrosarcoma oncogene	121					blood coagulation	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.75e-15)		CGCGCGCACCGTGGCCCGGGG	0.682													0	0	0	1	0	3	7										A	1579901	G	A	1579901	3	1	82	1	0	0	0	0	1	0	0	0	9161	1145	40	2	367	2	MAFK	7	1579901	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		1579901	157558762	183	24567										
CREB5	9586	broad.mit.edu	37	chr7	28858777	28858777	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtcctgtcccagcttgctccCagcaacaagtcatccagcat	7	16	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:28858777C>T	uc003szq.2	+	11	1798	c.1408C>T	c.(1408-1410)CAG>TAG	p.Q470*	CREB5_uc003szo.2_Nonsense_Mutation_p.Q437*|CREB5_uc003szr.2_Nonsense_Mutation_p.Q463*|CREB5_uc003szs.2_Nonsense_Mutation_p.Q331*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	470					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AGCTTGCTCCCAGCAACAAGT	0.502													0	0	0	1	0	46	81										T	28858777	C	T	28858777	4	4	82	1	0	0	0	0	0	1	0	0	3860	595	21	2	1501	2	CREB5	7	28858777	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	27278876	28858777	130279886	184	24568										
AOAH	313	broad.mit.edu	37	chr7	36726373	36726373	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtgaacttgagcaagctgttCtattacagacaccaccagca	8	11	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:36726373C>T	uc003tfh.3	-	2	555	c.154G>A	c.(154-156)GAA>AAA	p.E52K	AOAH_uc010kxf.2_Missense_Mutation_p.E52K|AOAH_uc011kba.1_Intron	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	52	Saposin B-type.				inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GCAAGCTGTTCTATTACAGAC	0.512													0	0	0	1	0	14	33										T	36726373	C	T	36726373	3	4	82	1	0	0	0	0	1	0	0	0	726	922	32	1	1994	1	AOAH	7	36726373	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7867596	36726373	122412290	185	24569										
NPC1L1	29881	broad.mit.edu	37	chr7	44556401	44556401	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atgacaatggagagcaggttGaggaggccggagcgcaggtc	18	7	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:44556401G>C	uc003tlb.2	-	17	3557	c.3501C>G	c.(3499-3501)CTC>CTG	p.L1167L	NPC1L1_uc003tlc.2_Silent_p.L1140L|NPC1L1_uc011kbw.1_Silent_p.L1094L|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1167	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	AGAGCAGGTTGAGGAGGCCGG	0.612													0	0	0	1	0	3	12										C	44556401	G	C	44556401	2	2	82	1	0	0	0	0	0	0	0	1	10571	1277	45	1		1	NPC1L1	7	44556401	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7830028	44556401	114582262	186	24570										
TNS3	64759	broad.mit.edu	37	chr7	47344505	47344505	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctgctgaaaggagggcgtcGaggacgcatcagcccggagc	16	12	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:47344505G>A	uc003tnv.2	-	21	3114	c.2747C>T	c.(2746-2748)TCG>TTG	p.S916L	TNS3_uc003tnw.2_Missense_Mutation_p.S916L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	916						focal adhesion	protein binding			ovary(4)	4						GGAGGGCGTCGAGGACGCATC	0.567													0	0	0	1	0	10	13										A	47344505	G	A	47344505	3	1	82	1	0	0	0	0	1	0	0	0	16341	1059	37	1	1634	1	TNS3	7	47344505	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2788104	47344505	111794158	187	24571										
ZNF107	51427	broad.mit.edu	37	chr7	64168093	64168093	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gagagaaaccctataaatgtGaggaatgtggcaaagctttt	11	5	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:64168093G>C	uc003ttd.2	+	7	2197	c.1411G>C	c.(1411-1413)GAG>CAG	p.E471Q	ZNF107_uc003tte.2_Missense_Mutation_p.E471Q	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	471	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CTATAAATGTGAGGAATGTGG	0.363													0	0	0	1	0	19	35										C	64168093	G	C	64168093	3	2	82	1	0	0	0	0	1	0	0	0	17712	1291	45	1	1417	1	ZNF107	7	64168093	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	16823588	64168093	94970570	188	24572										
TYW1	55253	broad.mit.edu	37	chr7	66463931	66463931	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tttttatggttctcagactgGaacagcgaaggtaagaaatt	10	5	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:66463931G>A	uc003tvn.2	+	3	412	c.263G>A	c.(262-264)GGA>GAA	p.G88E	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	88	FMN (By similarity).|Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				TCTCAGACTGGAACAGCGAAG	0.378													0	0	0	1	0	25	56										A	66463931	G	A	66463931	3	1	82	1	0	0	0	0	1	0	0	0	16815	1174	41	1	273	1	TYW1	7	66463931	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2295838	66463931	92674732	189	24573										
TRIM50	135892	broad.mit.edu	37	chr7	72738632	72738632	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgccggcacacggggcagcGcagctcggcatccaggtggc	16	15	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:72738632G>A	uc010lbd.1	-	2	279	c.154C>T	c.(154-156)CGC>TGC	p.R52C	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.R52C|TRIM50_uc003txz.1_Missense_Mutation_p.R52C	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	52	RING-type.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						ACGGGGCAGCGCAGCTCGGCA	0.677											OREG0018105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	23	44										A	72738632	G	A	72738632	3	1	82	1	0	0	0	0	1	0	0	0	16523	1087	38	2	1333	2	TRIM50	7	72738632	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6274701	72738632	86400031	190	24574										
PCLO	27445	broad.mit.edu	37	chr7	82583410	82583410	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taagtcagtagaaacagtgtCagcaactggcccttcaggtt	10	9	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:82583410C>T	uc003uhx.2	-	5	7148	c.6859G>A	c.(6859-6861)GAC>AAC	p.D2287N	PCLO_uc003uhv.2_Missense_Mutation_p.D2287N|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2218					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GAAACAGTGTCAGCAACTGGC	0.393													0	0	0	1	0	43	88										T	82583410	C	T	82583410	3	4	82	1	0	0	0	0	1	0	0	0	11583	826	29	1	8670	1	PCLO	7	82583410	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	9844778	82583410	76555253	191	24575										
DBF4	10926	broad.mit.edu	37	chr7	87533643	87533643	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aacacagaaactttgcacagAgtaaccagtatcaagttgtt	7	8	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:87533643A>G	uc003ujf.1	+	11	1465	c.961A>G	c.(961-963)AGT>GGT	p.S321G	DBF4_uc003ujh.1_Missense_Mutation_p.S61G|DBF4_uc003ujg.1_Missense_Mutation_p.S97G|DBF4_uc011khf.1_Missense_Mutation_p.S88G	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	321	DBF4-type.				cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				CTTTGCACAGAGTAACCAGTA	0.284													0	0	0	1	0	26	26										G	87533643	A	G	87533643	3	3	82	1	0	0	0	0	1	0	0	0	4248	304	11	5	1003	5	DBF4	7	87533643	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	4950233	87533643	71605020	192	24576										
ADAM22	53616	broad.mit.edu	37	chr7	87797475	87797475	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttgctggcaccaatatcataAtaggcataattgctggcacc	8	10	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:87797475A>T	uc003ujn.2	+	25	2294	c.2215A>T	c.(2215-2217)ATA>TTA	p.I739L	ADAM22_uc003ujk.1_Missense_Mutation_p.I739L|ADAM22_uc003ujl.1_Missense_Mutation_p.I739L|ADAM22_uc003ujm.2_Missense_Mutation_p.I739L|ADAM22_uc003ujo.2_Missense_Mutation_p.I739L|ADAM22_uc003ujp.1_Missense_Mutation_p.I791L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	739	Helical; (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CAATATCATAATAGGCATAAT	0.363													0	0	0	1	0	14	34										T	87797475	A	T	87797475	3	4	82	1	0	0	0	0	1	0	0	0	244	101	4	5	2313	5	ADAM22	7	87797475	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	263832	87797475	71341188	193	24577										
KRIT1	889	broad.mit.edu	37	chr7	91863905	91863905	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atcatctacccactgtcgttCcctaatcattaaaaagaaat	3	11	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:91863905C>T	uc003ulq.1	-	8	1018	c.847G>A	c.(847-849)GAA>AAA	p.E283K	KRIT1_uc010lev.1_Missense_Mutation_p.E76K|KRIT1_uc003ulr.1_Missense_Mutation_p.E283K|KRIT1_uc003uls.1_Missense_Mutation_p.E283K|KRIT1_uc003ult.1_Intron|KRIT1_uc003ulu.1_Missense_Mutation_p.E283K|KRIT1_uc003ulv.1_Missense_Mutation_p.E283K	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	283					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CACTGTCGTTCCCTAATCATT	0.368									Familial_Cerebral_Cavernous_Angioma				0	0	0	1	0	26	43										T	91863905	C	T	91863905	3	4	82	1	0	0	0	0	1	0	0	0	8445	869	30	1	1403	1	KRIT1	7	91863905	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4066430	91863905	67274758	194	24578										
CDK6	1021	broad.mit.edu	37	chr7	92462443	92462443	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcgaaggtctccaggtgcctCagcaccgccacctcgcggat	11	16	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:92462443C>T	uc011khw.1	-	2	607	c.195G>A	c.(193-195)CTG>CTA	p.L65L	CDK6_uc010lez.2_Silent_p.L65L	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	65	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CCAGGTGCCTCAGCACCGCCA	0.706			T	MLLT10	ALL						OREG0018165	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	5										T	92462443	C	T	92462443	2	4	82	1	0	0	0	0	0	0	0	1	3148	813	29	1		1	CDK6	7	92462443	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	598538	92462443	66676220	195	24579										
ZAN	7455	broad.mit.edu	37	chr7	100364685	100364685	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cactacctgaccttcgatggCgccttgcaccacttcatggg	9	15	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:100364685C>T	uc003uwj.2	+	25	4830	c.4665C>T	c.(4663-4665)GGC>GGT	p.G1555G	ZAN_uc003uwk.2_Silent_p.G1555G|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.G132G	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1555	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCTTCGATGGCGCCTTGCACC	0.602													0	0	0	1	0	15	39										T	100364685	C	T	100364685	2	4	82	1	0	0	0	0	0	0	0	1	17510	755	27	2		2	ZAN	7	100364685	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7902242	100364685	58773978	196	24580										
NAMPT	10135	broad.mit.edu	37	chr7	105909656	105909656	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taacttgtattccagaccatCtaagttaccagaagtttcta	5	9	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:105909656C>T	uc003vdq.2	-	5	858	c.550G>A	c.(550-552)GAT>AAT	p.D184N	NAMPT_uc003vdr.1_Missense_Mutation_p.D184N|NAMPT_uc011klu.1_Missense_Mutation_p.D97N	NM_005746	NP_005737	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	184					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			large_intestine(1)	1						TCCAGACCATCTAAGTTACCA	0.368													0	0	0	1	0	11	28										T	105909656	C	T	105909656	3	4	82	1	0	0	0	0	1	0	0	0	10149	913	32	1	953	1	NAMPT	7	105909656	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5544971	105909656	53229007	197	24581										
DLD	1738	broad.mit.edu	37	chr7	107531736	107531736	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtactgctccttggccaaggTgagggccgagtaggtgaggt	17	8	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:107531736T>A	uc003vet.2	+	1	149	c.39_splice	c.e1+2	p.K13_splice	DLD_uc010ljm.1_Splice_Site|DLD_uc011kmg.1_Splice_Site_p.K13_splice|DLD_uc011kmh.1_Splice_Site_p.K13_splice|DLD_uc011kmi.1_Splice_Site	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor						branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	TTGGCCAAGGTGAGGGCCGAG	0.622													0	0	0	1	0	12	21										A	107531736	T	A	107531736	5	1	82	1	0	0	0	0	0	0	1	0	4551	1710	59	5	43	5	DLD	7	107531736	Splice_Site	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	1622080	107531736	51606927	198	24582										
FOXP2	93986	broad.mit.edu	37	chr7	114299688	114299688	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aatttacagctggtttacacGgacatttgcttacttcaggc	8	9	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:114299688G>T	uc003vhb.2	+	13	1981	c.1607G>T	c.(1606-1608)CGG>CTG	p.R536L	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.R561L|FOXP2_uc003vha.2_Missense_Mutation_p.R444L|FOXP2_uc011kmu.1_Missense_Mutation_p.R553L|FOXP2_uc011kmv.1_Missense_Mutation_p.R535L|FOXP2_uc010ljz.1_Missense_Mutation_p.R351L|FOXP2_uc003vhe.1_Missense_Mutation_p.R106L	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	536	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TGGTTTACACGGACATTTGCT	0.343													1	0	0.00621372	1	0.00624553	9	78										T	114299688	G	T	114299688	3	4	82	1	0	0	0	0	1	0	0	0	6027	1116	39	4	1820	4	FOXP2	7	114299688	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6767952	114299688	44838975	199	24583										
RBM28	55131	broad.mit.edu	37	chr7	127961459	127961459	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	attctggtccttgagtttctGatgcttcagcagctcaaact	8	10	4	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:127961459G>C	uc003vmp.2	-	14	1538	c.1423C>G	c.(1423-1425)CAG>GAG	p.Q475E	RBM28_uc003vmo.2_Missense_Mutation_p.Q92E|RBM28_uc011koj.1_Missense_Mutation_p.Q334E	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	475					mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						TTGAGTTTCTGATGCTTCAGC	0.433													0	0	0	1	0	15	30										C	127961459	G	C	127961459	3	2	82	1	0	0	0	0	1	0	0	0	13128	1299	45	1	880	1	RBM28	7	127961459	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	13661771	127961459	31177204	200	24584										
TNPO3	23534	broad.mit.edu	37	chr7	128630024	128630024	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	attacacataccaaggaactGaggatttcgatcaacgactt	7	9	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:128630024G>A	uc003vol.1	-	11	1863	c.1489C>T	c.(1489-1491)CAG>TAG	p.Q497*	TNPO3_uc003vom.1_Nonsense_Mutation_p.Q431*|TNPO3_uc010lly.1_Nonsense_Mutation_p.Q531*|TNPO3_uc010llz.1_Nonsense_Mutation_p.Q497*	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	497					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						CCAAGGAACTGAGGATTTCGA	0.438													0	0	0	1	0	23	50										A	128630024	G	A	128630024	4	1	82	1	0	0	0	0	0	1	0	0	16334	1299	45	1	1330	1	TNPO3	7	128630024	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	668565	128630024	30508639	201	24585										
LUC7L2	51631	broad.mit.edu	37	chr7	139107066	139107066	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acaggaggagctctgaagagCgcgaagcaggggagatctaa	16	7	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:139107066C>T	uc003vux.2	+	10	1533	c.1159C>T	c.(1159-1161)CGC>TGC	p.R387C	LUC7L2_uc011kqs.1_Missense_Mutation_p.R384C|LUC7L2_uc011kqt.1_Missense_Mutation_p.R453C|LUC7L2_uc003vuy.2_Missense_Mutation_p.R386C|LUC7L2_uc003vva.2_Missense_Mutation_p.R334C	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	387	Arg/Ser-rich.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)					CTCTGAAGAGCGCGAAGCAGG	0.468													0	0	0	1	0	22	73										T	139107066	C	T	139107066	3	4	82	1	0	0	0	0	1	0	0	0	9083	768	27	2	1197	2	LUC7L2	7	139107066	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	10477042	139107066	20031597	202	24586										
EZH2	2146	broad.mit.edu	37	chr7	148523641	148523641	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agctttgctctctctgaacaGatttagcatttggtccatct	7	10	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:148523641G>T	uc003wfd.1	-	8	978	c.812C>A	c.(811-813)TCT>TAT	p.S271Y	EZH2_uc011kug.1_Missense_Mutation_p.S262Y|EZH2_uc003wfb.1_Missense_Mutation_p.S271Y|EZH2_uc003wfc.1_Missense_Mutation_p.S232Y|EZH2_uc011kuh.1_Missense_Mutation_p.S262Y|EZH2_uc011kui.1_Missense_Mutation_p.S271Y|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	271	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TCTCTGAACAGATTTAGCATT	0.423			Mis		DLBCL								1	0	6.72482e-11	1	6.9612e-11	15	37										T	148523641	G	T	148523641	3	4	82	1	0	0	0	0	1	0	0	0	5334	942	33	3	1495	3	EZH2	7	148523641	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	9416575	148523641	10615022	203	24587										
AGAP3	116988	broad.mit.edu	37	chr7	150817139	150817139	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtcccctccacccccagcatCagccagcgggagctgcgcat	10	19	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:150817139C>T	uc003wjg.1	+	8	1038	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	AGAP3_uc003wje.1_Silent_p.I117I|AGAP3_uc003wjf.1_Silent_p.I345I|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Silent_p.I525I|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	309	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						CCCCCAGCATCAGCCAGCGGG	0.652													0	0	0	1	0	18	12										T	150817139	C	T	150817139	2	4	82	1	0	0	0	0	0	0	0	1	369	816	29	1		1	AGAP3	7	150817139	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2293498	150817139	8321524	204	24588										
NOM1	64434	broad.mit.edu	37	chr7	156746908	156746908	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tccgctctcatgggtgcctgCgtcactgcctcggccatgcc	11	17	2	0	rs114285170	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:156746908C>T	uc003wmy.2	+	3	1239	c.1224C>T	c.(1222-1224)TGC>TGT	p.C408C		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	408	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		TGGGTGCCTGCGTCACTGCCT	0.542													0	0	0	1	0	4	45										T	156746908	C	T	156746908	2	4	82	1	0	0	0	0	0	0	0	1	10530	776	27	2		2	NOM1	7	156746908	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5929769	156746908	2391755	205	24589										
ESYT2	57488	broad.mit.edu	37	chr7	158557520	158557520	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cccctgaagatcctgagcttCaataaaatgtatccttagaa	6	10	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr7:158557520C>T	uc003wob.1	-	9	1159	c.1093G>A	c.(1093-1095)GAA>AAA	p.E365K	ESYT2_uc003woc.1_Missense_Mutation_p.E189K|ESYT2_uc003wod.1_Missense_Mutation_p.E365K|ESYT2_uc003woa.1_5'Flank	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	393	C2 1.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						TCCTGAGCTTCAATAAAATGT	0.428													0	0	0	1	0	34	64										T	158557520	C	T	158557520	3	4	82	1	0	0	0	0	1	0	0	0	5265	835	29	1	1644	1	ESYT2	7	158557520	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1810612	158557520	581143	206	24590										
CSMD1	64478	broad.mit.edu	37	chr8	4277529	4277529	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcgaagtctgtcgtgaaccAcagagtgaggatagatcctg	13	8	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:4277529A>G	uc011kwk.1	-	3	751	c.361T>C	c.(361-363)TGG>CGG	p.W121R		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	121	Extracellular (Potential).|CUB 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTCGTGAACCACAGAGTGAGG	0.413													0	0	0	1	0	3	5										G	4277529	A	G	4277529	3	3	82	1	0	0	0	0	1	0	0	0	3944	159	6	5	10418	5	CSMD1	8	4277529	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08		4277529	142086493	207	24591										
RP1L1	94137	broad.mit.edu	37	chr8	10467275	10467275	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgtgggttcctctgtgccctCtgcggggcacggctctgcag	15	13	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:10467275C>T	uc003wtc.2	-	4	4562	c.4333G>A	c.(4333-4335)GAG>AAG	p.E1445K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1445					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCTGTGCCCTCTGCGGGGCAC	0.632													0	0	0	1	0	99	126										T	10467275	C	T	10467275	3	4	82	1	0	0	0	0	1	0	0	0	13533	922	32	1	2873	1	RP1L1	8	10467275	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6189746	10467275	135896747	208	24592										
LONRF1	91694	broad.mit.edu	37	chr8	12583256	12583256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgaaggttttcctccctctCgggcattgatccgaaatgct	9	12	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:12583256C>T	uc003wwd.1	-	11	2206	c.2143G>A	c.(2143-2145)GAG>AAG	p.E715K	LONRF1_uc011kxv.1_Missense_Mutation_p.E304K|LONRF1_uc010lsp.1_Missense_Mutation_p.E315K	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	715	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		TCCTCCCTCTCGGGCATTGAT	0.393													0	0	0	1	0	22	39										T	12583256	C	T	12583256	3	4	82	1	0	0	0	0	1	0	0	0	8894	893	31	1	186	1	LONRF1	8	12583256	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2115981	12583256	133780766	209	24593										
DUSP4	1846	broad.mit.edu	37	chr8	29197718	29197718	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgccagggccttggttttaGaacagaattctgggtactcg	12	9	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:29197718G>C	uc003xhm.2	-	2	866	c.476C>G	c.(475-477)TCT>TGT	p.S159C	DUSP4_uc003xhl.2_Missense_Mutation_p.S68C	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	159	Rhodanese.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CTTGGTTTTAGAACAGAATTC	0.572											OREG0018686	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	5										C	29197718	G	C	29197718	3	2	82	1	0	0	0	0	1	0	0	0	4827	942	33	1	720	1	DUSP4	8	29197718	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	16614462	29197718	117166304	210	24594										
GTF2E2	2961	broad.mit.edu	37	chr8	30464631	30464631	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaaaagtattttcttcttatCgggacgatttacaaatagta	7	5	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:30464631C>T	uc003xig.2	-	6	839	c.586G>A	c.(586-588)GAT>AAT	p.D196N		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	196					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		TTCTTCTTATCGGGACGATTT	0.308													0	0	0	1	0	23	16										T	30464631	C	T	30464631	3	4	82	1	0	0	0	0	1	0	0	0	6857	884	31	1	301	1	GTF2E2	8	30464631	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1266913	30464631	115899391	211	24595										
PRKDC	5591	broad.mit.edu	37	chr8	48749802	48749802	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcattctgacagaggatgctCgaacatggggtttggataat	13	6	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:48749802C>T	uc003xqi.2	-	58	7789	c.7732G>A	c.(7732-7734)GAG>AAG	p.E2578K	PRKDC_uc003xqj.2_Missense_Mutation_p.E2578K|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2578	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGAGGATGCTCGAACATGGGG	0.373								NHEJ					0	0	0	1	0	6	16										T	48749802	C	T	48749802	3	4	82	1	0	0	0	0	1	0	0	0	12521	893	31	1	4774	1	PRKDC	8	48749802	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	18285171	48749802	97614220	212	24596										
NPBWR1	2831	broad.mit.edu	37	chr8	53853373	53853373	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agctacgccaacagctgcctCaaccccttcctctacgcctt	5	19	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:53853373C>T	uc011ldu.1	+	1	906	c.906C>T	c.(904-906)CTC>CTT	p.L302L		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	302	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				ACAGCTGCCTCAACCCCTTCC	0.652													0	0	0	1	0	12	35										T	53853373	C	T	53853373	2	4	82	1	0	0	0	0	0	0	0	1	10568	813	29	1		1	NPBWR1	8	53853373	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5103571	53853373	92510649	213	24597										
TGS1	96764	broad.mit.edu	37	chr8	56699306	56699306	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acagaagctgatgacaagaaCgatgaaaaatgcatgaaagt	10	5	0	6	rs146870824	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:56699306C>A	uc003xsj.3	+	4	1236	c.849C>A	c.(847-849)AAC>AAA	p.N283K	TGS1_uc010lyh.2_Missense_Mutation_p.N187K	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	283					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ATGACAAGAACGATGAAAAAT	0.368													1	0	1.86633e-21	1	1.96298e-21	50	95										A	56699306	C	A	56699306	3	1	82	1	0	0	0	0	1	0	0	0	15834	535	19	4	863	4	TGS1	8	56699306	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2845933	56699306	89664716	214	24598										
IMPAD1	54928	broad.mit.edu	37	chr8	57905976	57905976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	caagtccacggtgcccccatCggccgcggccgcgggccccg	14	20	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:57905976C>T	uc003xte.3	-	1	452	c.169G>A	c.(169-171)GAT>AAT	p.D57N		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	57						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				GTGCCCCCATcggccgcggcc	0.577													0	0	0	1	0	6	8										T	57905976	C	T	57905976	3	4	82	1	0	0	0	0	1	0	0	0	7725	884	31	1	930	1	IMPAD1	8	57905976	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1206670	57905976	88458046	215	24599										
TOX	9760	broad.mit.edu	37	chr8	59720693	59720693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttacccactactgcagtagtCgttattccagtccaccggtt	7	13	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:59720693C>T	uc003xtw.1	-	8	1749	c.1528G>A	c.(1528-1530)GAC>AAC	p.D510N		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	510						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CTGCAGTAGTCGTTATTCCAG	0.537											OREG0018787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	21	43										T	59720693	C	T	59720693	3	4	82	1	0	0	0	0	1	0	0	0	16374	884	31	1	60	1	TOX	8	59720693	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1814717	59720693	86643329	216	24600										
RRS1	23212	broad.mit.edu	37	chr8	67342183	67342183	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agaaccagttggagctgcttCgtgtcatgaacagcaagaag	12	8	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:67342183C>T	uc003xwa.2	+	1	921	c.817C>T	c.(817-819)CGT>TGT	p.R273C	ADHFE1_uc003xwb.3_5'Flank|ADHFE1_uc003xwd.3_5'Flank|ADHFE1_uc003xwc.3_5'Flank|ADHFE1_uc003xwe.3_5'Flank|ADHFE1_uc003xwf.3_5'Flank|ADHFE1_uc011les.1_5'Flank|ADHFE1_uc011leq.1_5'Flank|ADHFE1_uc011ler.1_5'Flank	NM_015169	NP_055984	Q15050	RRS1_HUMAN	homolog of yeast ribosome biogenesis regulatory	273					mitotic metaphase plate congression|ribosome biogenesis	condensed nuclear chromosome|nucleolus					0		Lung NSC(129;0.197)	Epithelial(68;0.0391)|all cancers(69;0.0898)|BRCA - Breast invasive adenocarcinoma(89;0.111)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			GGAGCTGCTTCGTGTCATGAA	0.557													0	0	0	1	0	14	25										T	67342183	C	T	67342183	3	4	82	1	0	0	0	0	1	0	0	0	13692	884	31	1	819	1	RRS1	8	67342183	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7621490	67342183	79021839	217	24601										
RDH10	157506	broad.mit.edu	37	chr8	74231361	74231361	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttttcttcctacgatgctgGagattaatcatggtcatatt	7	8	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:74231361G>C	uc003xzi.2	+	3	816	c.556G>C	c.(556-558)GAG>CAG	p.E186Q	RDH10_uc003xzj.2_Missense_Mutation_p.E21Q|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	186					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			TACGATGCTGGAGATTAATCA	0.383													0	0	0	1	0	45	78										C	74231361	G	C	74231361	3	2	82	1	0	0	0	0	1	0	0	0	13189	1175	41	1	566	1	RDH10	8	74231361	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6889178	74231361	72132661	218	24602										
LRRCC1	85444	broad.mit.edu	37	chr8	86048162	86048162	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taatatttggtttaaggacaGaaagaaaagtatggggacat	11	2	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:86048162G>C	uc003ycw.2	+	14	2447	c.2293G>C	c.(2293-2295)GAA>CAA	p.E765Q	LRRCC1_uc010maa.1_Missense_Mutation_p.E466Q|LRRCC1_uc003ycx.2_Missense_Mutation_p.E672Q|LRRCC1_uc003ycy.2_Missense_Mutation_p.E745Q	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	765					cell division|mitosis	centriole|nucleus					0						TTTAAGGACAGAAAGAAAAGT	0.363													0	0	0	1	0	20	34										C	86048162	G	C	86048162	3	2	82	1	0	0	0	0	1	0	0	0	9026	943	33	1	2347	1	LRRCC1	8	86048162	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	11816801	86048162	60315860	219	24603										
RAD54B	25788	broad.mit.edu	37	chr8	95419768	95419768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttttgaaagggttagagaaaCatttcctggcaacctgagaa	10	6	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:95419768C>T	uc003ygk.2	-	5	778	c.680G>A	c.(679-681)TGT>TAT	p.C227Y	RAD54B_uc010may.1_Missense_Mutation_p.C34Y|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GTTAGAGAAACATTTCCTGGC	0.428								Direct_reversal_of_damage|Homologous_recombination					0	0	0	1	0	27	53										T	95419768	C	T	95419768	3	4	82	1	0	0	0	0	1	0	0	0	12992	478	17	2	2096	2	RAD54B	8	95419768	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	9371606	95419768	50944254	220	24604										
OSR2	116039	broad.mit.edu	37	chr8	99961579	99961579	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	caagaggatccgcctaagatGggagacctgagcaagctgag	14	9	0	5			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:99961579G>C	uc003yir.2	+	2	934	c.399G>C	c.(397-399)ATG>ATC	p.M133I	OSR2_uc010mbn.2_Missense_Mutation_p.M133I|OSR2_uc003yiq.2_Missense_Mutation_p.M133I|OSR2_uc011lgx.1_Missense_Mutation_p.M254I	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	133					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			CGCCTAAGATGGGAGACCTGA	0.612													0	0	0	1	0	48	103										C	99961579	G	C	99961579	3	2	82	1	0	0	0	0	1	0	0	0	11294	1348	47	4	401	4	OSR2	8	99961579	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4541811	99961579	46402443	221	24605										
FAM83H	286077	broad.mit.edu	37	chr8	144810877	144810877	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	caggctgcggtggatcttctCaaaggaccacatgaagctgt	12	10	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144810877C>G	uc003yzk.2	-	5	823	c.754G>C	c.(754-756)GAG>CAG	p.E252Q	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	252					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TGGATCTTCTCAAAGGACCAC	0.657													0	0	0	1	0	13	28										G	144810877	C	G	144810877	3	3	82	1	0	0	0	0	1	0	0	0	5640	835	29	1	2789	1	FAM83H	8	144810877	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	44849298	144810877	1553145	222	24606										
PLEC	5339	broad.mit.edu	37	chr8	144995372	144995372	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	caggcccgtctcggggtcctCcacgcagcgctccagtagct	12	17	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144995372C>G	uc003zaf.1	-	32	9198	c.9028G>C	c.(9028-9030)GAG>CAG	p.E3010Q	PLEC_uc003zab.1_Missense_Mutation_p.E2873Q|PLEC_uc003zac.1_Missense_Mutation_p.E2877Q|PLEC_uc003zad.2_Missense_Mutation_p.E2873Q|PLEC_uc003zae.1_Missense_Mutation_p.E2841Q|PLEC_uc003zag.1_Missense_Mutation_p.E2851Q|PLEC_uc003zah.2_Missense_Mutation_p.E2859Q|PLEC_uc003zaj.2_Missense_Mutation_p.E2900Q	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3010	Globular 2.|Plectin 5.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCGGGGTCCTCCACGCAGCGC	0.647													0	0	0	1	0	41	76										G	144995372	C	G	144995372	3	3	82	1	0	0	0	0	1	0	0	0	12052	864	30	1	5030	1	PLEC	8	144995372	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	184495	144995372	1368650	223	24607			2	111		5	5	1924	C		2.683471e-08
PLEC	5339	broad.mit.edu	37	chr8	144995411	144995411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgcaggtacgtgaggttctCgtgcgtgttggggtcaaaga	16	7	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144995411C>T	uc003zaf.1	-	32	9159	c.8989G>A	c.(8989-8991)GAG>AAG	p.E2997K	PLEC_uc003zab.1_Missense_Mutation_p.E2860K|PLEC_uc003zac.1_Missense_Mutation_p.E2864K|PLEC_uc003zad.2_Missense_Mutation_p.E2860K|PLEC_uc003zae.1_Missense_Mutation_p.E2828K|PLEC_uc003zag.1_Missense_Mutation_p.E2838K|PLEC_uc003zah.2_Missense_Mutation_p.E2846K|PLEC_uc003zaj.2_Missense_Mutation_p.E2887K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2997	Globular 2.|Plectin 5.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GTGAGGTTCTCGTGCGTGTTG	0.657													0	0	0	1	0	45	81										T	144995411	C	T	144995411	3	4	82	1	0	0	0	0	1	0	0	0	12052	893	31	1	5069	1	PLEC	8	144995411	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	39	144995411	1368611	224	24608			2	111		5	5	1924	C		2.683471e-08
PLEC	5339	broad.mit.edu	37	chr8	144995865	144995865	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcggcgtaaacactcagcttCtcattggtggccttcagcaa	10	12	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144995865C>G	uc003zaf.1	-	32	8705	c.8535G>C	c.(8533-8535)GAG>GAC	p.E2845D	PLEC_uc003zab.1_Missense_Mutation_p.E2708D|PLEC_uc003zac.1_Missense_Mutation_p.E2712D|PLEC_uc003zad.2_Missense_Mutation_p.E2708D|PLEC_uc003zae.1_Missense_Mutation_p.E2676D|PLEC_uc003zag.1_Missense_Mutation_p.E2686D|PLEC_uc003zah.2_Missense_Mutation_p.E2694D|PLEC_uc003zaj.2_Missense_Mutation_p.E2735D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2845	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CACTCAGCTTCTCATTGGTGG	0.672													0	0	0	1	0	20	39										G	144995865	C	G	144995865	3	3	82	1	0	0	0	0	1	0	0	0	12052	912	32	1	5523	1	PLEC	8	144995865	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	454	144995865	1368157	225	24609			2	111		5	5	1924	C		2.683471e-08
PLEC	5339	broad.mit.edu	37	chr8	144996723	144996723	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcctgttggagcttctccttCtcacgctccagctcagcgat	8	15	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144996723C>G	uc003zaf.1	-	31	7955	c.7785G>C	c.(7783-7785)GAG>GAC	p.E2595D	PLEC_uc003zab.1_Missense_Mutation_p.E2458D|PLEC_uc003zac.1_Missense_Mutation_p.E2462D|PLEC_uc003zad.2_Missense_Mutation_p.E2458D|PLEC_uc003zae.1_Missense_Mutation_p.E2426D|PLEC_uc003zag.1_Missense_Mutation_p.E2436D|PLEC_uc003zah.2_Missense_Mutation_p.E2444D|PLEC_uc003zaj.2_Missense_Mutation_p.E2485D	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2595	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCTTCTCCTTCTCACGCTCCA	0.637													0	0	0	1	0	9	19										G	144996723	C	G	144996723	3	3	82	1	0	0	0	0	1	0	0	0	12052	912	32	1	6277	1	PLEC	8	144996723	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	858	144996723	1367299	226	24610			2	111		5	5	1924	C		2.683471e-08
PLEC	5339	broad.mit.edu	37	chr8	144997295	144997295	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttcatcttctcagcctcctCctgcaggaagcgctgcgtat	8	15	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:144997295C>A	uc003zaf.1	-	31	7383	c.7213G>T	c.(7213-7215)GAG>TAG	p.E2405*	PLEC_uc003zab.1_Nonsense_Mutation_p.E2268*|PLEC_uc003zac.1_Nonsense_Mutation_p.E2272*|PLEC_uc003zad.2_Nonsense_Mutation_p.E2268*|PLEC_uc003zae.1_Nonsense_Mutation_p.E2236*|PLEC_uc003zag.1_Nonsense_Mutation_p.E2246*|PLEC_uc003zah.2_Nonsense_Mutation_p.E2254*|PLEC_uc003zaj.2_Nonsense_Mutation_p.E2295*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2405	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCAGCCTCCTCCTGCAGGAAG	0.642													1	0	3.07112e-06	1	3.13499e-06	9	21										A	144997295	C	A	144997295	4	1	82	1	0	0	0	0	0	1	0	0	12052	864	30	3	6849	3	PLEC	8	144997295	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	572	144997295	1366727	227	24611			2	111		5	5	1924	C		2.683471e-08
PPP1R16A	84988	broad.mit.edu	37	chr8	145726105	145726105	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgctcgtggcgcacggggccGacctgaacgcaaagtccctg	14	14	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr8:145726105G>T	uc003zdd.2	+	8	1781	c.868G>T	c.(868-870)GAC>TAC	p.D290Y	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.D290Y|GPT_uc011lli.1_5'Flank	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	290	ANK 5.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCACGGGGCCGACCTGAACGC	0.721													1	0	3.09899e-07	1	3.17444e-07	9	8										T	145726105	G	T	145726105	3	4	82	1	0	0	0	0	1	0	0	0	12365	1058	37	3	894	3	PPP1R16A	8	145726105	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	728810	145726105	637917	228	24612										
SMARCA2	6595	broad.mit.edu	37	chr9	2115859	2115859	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccgagctcaccgcatcgggcAgcagaacgaggtccgggtac	14	14	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:2115859A>C	uc003zhc.2	+	25	3593	c.3494A>C	c.(3493-3495)CAG>CCG	p.Q1165P	SMARCA2_uc003zhd.2_Missense_Mutation_p.Q1165P|SMARCA2_uc010mha.2_Missense_Mutation_p.Q1098P	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1165	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CGCATCGGGCAGCAGAACGAG	0.562													0	0	0	1	0	9	8										C	2115859	A	C	2115859	3	2	82	1	0	0	0	0	1	0	0	0	14769	188	7	5	3588	5	SMARCA2	9	2115859	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08		2115859	139097572	229	24613										
C9orf102	375748	broad.mit.edu	37	chr9	98660209	98660209	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ataacatgccagagtttttaCtaagaagtatgaaaaaggaa	8	4	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:98660209C>T	uc004avt.3	+	3	971	c.583C>T	c.(583-585)CTA>TTA	p.L195L	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_5'UTR|C9orf102_uc010mry.1_5'UTR|C9orf102_uc010mrz.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	195	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				AGAGTTTTTACTAAGAAGTAT	0.338													0	0	0	1	0	31	62										T	98660209	C	T	98660209	2	4	82	1	0	0	0	0	0	0	0	1	2445	564	20	2		2	C9orf102	9	98660209	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	96544350	98660209	42553222	230	24614										
KIAA1529	57653	broad.mit.edu	37	chr9	100092767	100092767	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gatcaagaaatggagtccttCataactgaagaggtgctggg	13	6	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:100092767C>G	uc011lut.1	+	30	3314	c.2541C>G	c.(2539-2541)TTC>TTG	p.F847L	KIAA1529_uc004axe.1_Missense_Mutation_p.F847L|KIAA1529_uc004axg.1_Missense_Mutation_p.F708L|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.F32L|KIAA1529_uc011lus.1_Missense_Mutation_p.F665L|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.F708L|KIAA1529_uc011luv.1_Missense_Mutation_p.F705L	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TGGAGTCCTTCATAACTGAAG	0.463													0	0	0	1	0	16	36										G	100092767	C	G	100092767	3	3	82	1	0	0	0	0	1	0	0	0	8240	825	29	1	2623	1	KIAA1529	9	100092767	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1432558	100092767	41120664	231	24615										
TRIM14	9830	broad.mit.edu	37	chr9	100850218	100850218	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccagcaggccgcagcgcaccGtcaggcgatcggcggacagg	16	15	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:100850218G>T	uc004ayd.2	-	6	881	c.863C>A	c.(862-864)ACG>AAG	p.T288K	TRIM14_uc004ayf.1_Missense_Mutation_p.T195K|TRIM14_uc011luz.1_Missense_Mutation_p.T66K|TRIM14_uc011lva.1_Missense_Mutation_p.T69K|TRIM14_uc004ayg.1_Missense_Mutation_p.T288K|TRIM14_uc004ayh.1_Missense_Mutation_p.T288K|TRIM14_uc004ayi.1_Intron|TRIM14_uc004ayj.1_Missense_Mutation_p.T195K	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha	288	B30.2/SPRY.					cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCAGCGCACCGTCAGGCGATC	0.736													1	0	0.115264	1	0.115264	3	8										T	100850218	G	T	100850218	3	4	82	1	0	0	0	0	1	0	0	0	16486	1145	40	4	469	4	TRIM14	9	100850218	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	757451	100850218	40363213	232	24616										
LCN2	3934	broad.mit.edu	37	chr9	130911943	130911943	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agaacttccaggacaaccaaGtaaggggccaagaggggcac	13	10	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:130911943G>A	uc004bto.1	+	1	211	c.138_splice	c.e1+1	p.Q46_splice	LCN2_uc010mxq.1_Splice_Site_p.Q46_splice|LCN2_uc011map.1_Splice_Site_p.Q46_splice	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor						apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						GGACAACCAAGTAAGGGGCCA	0.637													0	0	0	1	0	18	33										A	130911943	G	A	130911943	5	1	82	1	0	0	0	0	0	0	1	0	8684	1043	36	2	141	2	LCN2	9	130911943	Splice_Site	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	30061725	130911943	10301488	233	24617										
SPTAN1	6709	broad.mit.edu	37	chr9	131392643	131392643	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggaccctcgaatcccagcttGaagctaccaaagtaagtgcc	9	13	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:131392643G>A	uc004bvl.3	+	51	6849	c.6736G>A	c.(6736-6738)GAA>AAA	p.E2246K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E2251K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E2226K|SPTAN1_uc004bvo.3_Missense_Mutation_p.E13K|SPTAN1_uc004bvp.3_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2246	Spectrin 23.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATCCCAGCTTGAAGCTACCAA	0.607													0	0	0	1	0	22	33										A	131392643	G	A	131392643	3	1	82	1	0	0	0	0	1	0	0	0	15116	1291	45	1	6953	1	SPTAN1	9	131392643	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	480700	131392643	9820788	234	24618										
ABL1	25	broad.mit.edu	37	chr9	133759700	133759700	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tccccaatggagccctccggGagtccgggggctcaggcttc	14	15	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:133759700G>A	uc004bzw.2	+	11	2026	c.2023G>A	c.(2023-2025)GAG>AAG	p.E675K	ABL1_uc004bzv.2_Missense_Mutation_p.E694K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	675					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	AGCCCTCCGGGAGTCCGGGGG	0.682			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	1	0	20	24										A	133759700	G	A	133759700	3	1	82	1	0	0	0	0	1	0	0	0	92	1175	41	1	2205	1	ABL1	9	133759700	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2367057	133759700	7453731	235	24619										
TSC1	7248	broad.mit.edu	37	chr9	135781455	135781455	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtctcggtaaaagggagagtCaaagcctcctcgaggaacca	12	10	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:135781455C>T	uc004cca.2	-	15	1744	c.1510G>A	c.(1510-1512)GAC>AAC	p.D504N	TSC1_uc004ccb.3_Missense_Mutation_p.D503N|TSC1_uc011mcq.1_Missense_Mutation_p.D453N|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	504					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AAGGGAGAGTCAAAGCCTCCT	0.532			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	1	0	11	23										T	135781455	C	T	135781455	3	4	82	1	0	0	0	0	1	0	0	0	16602	826	29	1	2020	1	TSC1	9	135781455	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2021755	135781455	5431976	236	24620										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													0	0	0	1	0	25	48										T	137328351	C	T	137328351	3	4	82	1	0	0	0	0	1	0	0	0	13763	855	30	1	1318	1	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1546896	137328351	3885080	237	24621										
ANAPC2	29882	broad.mit.edu	37	chr9	140069557	140069557	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgttgtagatacgatccagtGagaggctctccaggttggtc	13	8	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:140069557G>A	uc004clr.1	-	13	2379	c.2306C>T	c.(2305-2307)TCA>TTA	p.S769L	ANAPC2_uc004clq.1_Missense_Mutation_p.S625L	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	769					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		ACGATCCAGTGAGAGGCTCTC	0.622													0	0	0	1	0	3	11										A	140069557	G	A	140069557	3	1	82	1	0	0	0	0	1	0	0	0	603	1294	45	1	166	1	ANAPC2	9	140069557	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2741206	140069557	1143874	238	24622										
MRPL41	64975	broad.mit.edu	37	chr9	140446839	140446839	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtggcgcctgccatcgaaaaGgacttcaaggacggtacctt	12	11	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr9:140446839G>A	uc004cnh.3	+	2	436	c.306G>A	c.(304-306)AAG>AAA	p.K102K	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	102					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		CCATCGAAAAGGACTTCAAGG	0.612													0	0	0	1	0	13	18										A	140446839	G	A	140446839	2	1	82	1	0	0	0	0	0	0	0	1	9805	991	35	2		2	MRPL41	9	140446839	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	377282	140446839	766592	239	24623										
KLF6	1316	broad.mit.edu	37	chr10	3824148	3824148	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggaggtaaacttggccgtggGagaaagttcctcggagctgt	16	7	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:3824148G>A	uc001iha.2	-	2	628	c.361C>T	c.(361-363)CCC>TCC	p.P121S	KLF6_uc010qaj.1_Missense_Mutation_p.P121S|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Missense_Mutation_p.P121S|KLF6_uc001ihb.2_Missense_Mutation_p.P121S	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	121					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		TTGGCCGTGGGAGAAAGTTCC	0.532											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	45	93										A	3824148	G	A	3824148	3	1	82	1	0	0	0	0	1	0	0	0	8350	1174	41	1	502	1	KLF6	10	3824148	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		3824148	131710599	240	24624										
ATP5C1	509	broad.mit.edu	37	chr10	7844317	7844317	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggccaacatcatctactactCtctgaaggagtccaccacta	6	14	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:7844317C>T	uc001iju.2	+	7	800	c.722C>T	c.(721-723)TCT>TTT	p.S241F	ATP5C1_uc009xiq.1_Missense_Mutation_p.S241F|ATP5C1_uc010qbc.1_Missense_Mutation_p.S192F|ATP5C1_uc001ijv.2_Missense_Mutation_p.S241F	NM_001001973	NP_001001973	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	241					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						ATCTACTACTCTCTGAAGGAG	0.448													0	0	0	1	0	14	40										T	7844317	C	T	7844317	3	4	82	1	0	0	0	0	1	0	0	0	1149	913	32	1	748	1	ATP5C1	10	7844317	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4020169	7844317	127690430	241	24625										
PRPF18	8559	broad.mit.edu	37	chr10	13652044	13652044	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttttgcttttcttagggattGaggaatgatttgaaagcagc	11	4	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:13652044G>C	uc001imp.2	+	5	517	c.369G>C	c.(367-369)TTG>TTC	p.L123F	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	123					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						CTTAGGGATTGAGGAATGATT	0.383													0	0	0	1	0	23	62										C	13652044	G	C	13652044	3	2	82	1	0	0	0	0	1	0	0	0	12563	1281	45	1	387	1	PRPF18	10	13652044	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	5807727	13652044	121882703	242	24626										
THNSL1	79896	broad.mit.edu	37	chr10	25312422	25312422	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atagatgtggatgatgatatCcttgaaaaaacctggaatat	9	4	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:25312422C>A	uc001isi.3	+	3	599	c.270C>A	c.(268-270)ATC>ATA	p.I90I	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	90					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	ATGATGATATCCTTGAAAAAA	0.383													1	0	1.06647e-15	1	1.11771e-15	38	73										A	25312422	C	A	25312422	2	1	82	1	0	0	0	0	0	0	0	1	15859	845	30	3		3	THNSL1	10	25312422	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	11660378	25312422	110222325	243	24627										
GPR158	57512	broad.mit.edu	37	chr10	25464862	25464862	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctggagggcgagcccagcatCtcccgggcggccatcacctt	13	16	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:25464862C>G	uc001isj.2	+	1	573	c.513C>G	c.(511-513)ATC>ATG	p.I171M	LOC100128811_uc010qde.1_Missense_Mutation_p.E30D	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	171	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AGCCCAGCATCTCCCGGGCGG	0.647													0	0	0	1	0	18	36										G	25464862	C	G	25464862	3	3	82	1	0	0	0	0	1	0	0	0	6663	903	32	1	515	1	GPR158	10	25464862	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	152440	25464862	110069885	244	24628										
ABI1	10006	broad.mit.edu	37	chr10	27048155	27048155	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	catactgggaaccaggagctGagcccggggctgctgaaaag	15	10	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:27048155G>A	uc001isx.2	-	9	1081	c.914C>T	c.(913-915)TCA>TTA	p.S305L	ABI1_uc001ite.2_Missense_Mutation_p.S272L|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Missense_Mutation_p.S278L|ABI1_uc001ita.2_Missense_Mutation_p.S278L|ABI1_uc001isz.2_Missense_Mutation_p.S273L|ABI1_uc001itb.2_Missense_Mutation_p.S322L|ABI1_uc001itc.2_Missense_Mutation_p.S277L|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Missense_Mutation_p.S277L|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Missense_Mutation_p.S144L	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	305	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						ACCAGGAGCTGAGCCCGGGGC	0.498													0	0	0	1	0	14	47										A	27048155	G	A	27048155	3	1	82	1	0	0	0	0	1	0	0	0	88	1294	45	1	628	1	ABI1	10	27048155	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1583293	27048155	108486592	245	24629										
KIAA1462	57608	broad.mit.edu	37	chr10	30316005	30316005	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctgcccccctctctccaccActgtcaaacttccgagggac	6	20	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:30316005A>G	uc001iux.2	-	2	3131	c.3072T>C	c.(3070-3072)AGT>AGC	p.S1024S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.S886S|KIAA1462_uc009xle.1_Silent_p.S1024S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1024										ovary(4)	4						TCTCTCCACCACTGTCAAACT	0.582													0	0	0	1	0	54	80										G	30316005	A	G	30316005	2	3	82	1	0	0	0	0	0	0	0	1	8234	156	6	5		5	KIAA1462	10	30316005	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	3267850	30316005	105218742	246	24630										
HK1	3098	broad.mit.edu	37	chr10	71119661	71119661	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctccctaaacagaaaagggaGatttcattgccctggatctt	8	10	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:71119661G>A	uc001jpl.3	+	3	336	c.235G>A	c.(235-237)GAT>AAT	p.D79N	HK1_uc001jpg.3_Missense_Mutation_p.D67N|HK1_uc001jph.3_Missense_Mutation_p.D83N|HK1_uc001jpi.3_Missense_Mutation_p.D83N|HK1_uc001jpj.3_Missense_Mutation_p.D114N|HK1_uc001jpk.3_Missense_Mutation_p.D78N|HK1_uc009xqd.2_Intron	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	79	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						AGAAAAGGGAGATTTCATTGC	0.483													0	0	0	1	0	32	53										A	71119661	G	A	71119661	3	1	82	1	0	0	0	0	1	0	0	0	7190	942	33	1	423	1	HK1	10	71119661	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	40803656	71119661	64415086	247	24631										
NPFFR1	64106	broad.mit.edu	37	chr10	72026099	72026099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gggtggcctcagtgttagtcCcattctgacttaggggccaa	13	10	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:72026099C>T	uc010qjk.1	-	1	56	c.50G>A	c.(49-51)GGG>GAG	p.G17E		NM_022146	NP_071429	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	19	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide receptor activity				0						AGTGTTAGTCCCATTCTGACT	0.552													0	0	0	1	0	5	21										T	72026099	C	T	72026099	3	4	82	1	0	0	0	0	1	0	0	0	10577	623	22	2	1247	2	NPFFR1	10	72026099	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	906438	72026099	63508648	248	24632										
CDH23	64072	broad.mit.edu	37	chr10	73553278	73553278	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgtcattgccaatatcacggCcattgaccacgacctcaacc	6	15	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:73553278C>A	uc001jrx.3	+	46	6970	c.6593C>A	c.(6592-6594)GCC>GAC	p.A2198D	CDH23_uc001jsg.3_5'Flank|CDH23_uc001jsh.3_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2198	Cadherin 21.|Extracellular (Potential).			EFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVG IVAKDDTDRLVPNQEDAFAVNIN -> ASWEGQSHVTQAYE EAVGPPQPQVPDSTGDRHPLWGLGGFGQEHPWEGQILGGSS QAEPGLVWS (in Ref. 6; BAB61902).	calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						AATATCACGGCCATTGACCAC	0.572													1	0	2.89027e-11	1	2.99713e-11	23	23										A	73553278	C	A	73553278	3	1	82	1	0	0	0	0	1	0	0	0	3108	739	26	4	7124	4	CDH23	10	73553278	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1527179	73553278	61981469	249	24633										
OIT3	170392	broad.mit.edu	37	chr10	74684374	74684374	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccacctccaagatcgacgagGtcctgaaatactacctcatc	6	15	1	2	rs139078371		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:74684374G>A	uc001jte.1	+	7	1557	c.1339G>A	c.(1339-1341)GTC>ATC	p.V447I	OIT3_uc009xqs.1_Intron	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	447	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					GATCGACGAGGTCCTGAAATA	0.552													0	0	0	1	0	14	34										A	74684374	G	A	74684374	3	1	82	1	0	0	0	0	1	0	0	0	10849	1261	44	2	1365	2	OIT3	10	74684374	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1131096	74684374	60850373	250	24634										
ECD	11319	broad.mit.edu	37	chr10	74899248	74899248	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggtgagagatctaaccactGgtcatctgaaaaagaagaaa	10	6	3	5			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:74899248G>A	uc001jtn.2	-	11	1483	c.1240C>T	c.(1240-1242)CAG>TAG	p.Q414*	ECD_uc009xqx.2_Nonsense_Mutation_p.Q447*|ECD_uc009xqy.2_Nonsense_Mutation_p.Q371*|ECD_uc001jto.2_Nonsense_Mutation_p.Q113*	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	414					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					TCTAACCACTGGTCATCTGAA	0.428													0	0	0	1	0	37	72										A	74899248	G	A	74899248	4	1	82	1	0	0	0	0	0	1	0	0	4888	1357	47	2	710	2	ECD	10	74899248	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	214874	74899248	60635499	251	24635										
LRIT2	340745	broad.mit.edu	37	chr10	85984111	85984111	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcaaattctctccacatactCaggggataagtccatgcaat	6	11	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:85984111C>T	uc001kcy.2	-	2	878	c.870G>A	c.(868-870)CTG>CTA	p.L290L	LRIT2_uc010qmc.1_Silent_p.L290L	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	290	Ig-like.					integral to membrane				ovary(2)	2						TCCACATACTCAGGGGATAAG	0.527													0	0	0	1	0	24	21										T	85984111	C	T	85984111	2	4	82	1	0	0	0	0	0	0	0	1	8948	813	29	1		1	LRIT2	10	85984111	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	11084863	85984111	49550636	252	24636										
PLCE1	51196	broad.mit.edu	37	chr10	96012152	96012152	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acggtggagtgctcgaaaccCcagccccggaacatcagcaa	11	14	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:96012152C>G	uc001kjk.2	+	9	3810	c.3176C>G	c.(3175-3177)CCC>CGC	p.P1059R	PLCE1_uc010qnx.1_Missense_Mutation_p.P1059R|PLCE1_uc001kjm.2_Missense_Mutation_p.P751R	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1059					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GCTCGAAACCCCAGCCCCGGA	0.507													0	0	0	1	0	14	44										G	96012152	C	G	96012152	3	3	82	1	0	0	0	0	1	0	0	0	12034	623	22	4	3492	4	PLCE1	10	96012152	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	10028041	96012152	39522595	253	24637										
TLX1	3195	broad.mit.edu	37	chr10	102894051	102894051	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agaagtacctggcctcggccGagcgcgccgccctggccaag	14	16	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:102894051G>A	uc001ksw.2	+	2	926	c.688G>A	c.(688-690)GAG>AAG	p.E230K		NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	230	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GGCCTCGGCCGAGCGCGCCGC	0.602			T	TRB@|TRD@	T-ALL								0	0	0	1	0	10	9										A	102894051	G	A	102894051	3	1	82	1	0	0	0	0	1	0	0	0	15956	1059	37	1	694	1	TLX1	10	102894051	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6881899	102894051	32640696	254	24638										
LDB1	8861	broad.mit.edu	37	chr10	103868831	103868831	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtgctagctgggctcttcttCttgctgttgctgttgttggt	13	8	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:103868831C>T	uc009xwz.2	-	10	1303	c.960G>A	c.(958-960)AAG>AAA	p.K320K	LDB1_uc001kuk.3_Silent_p.K284K|LDB1_uc001kul.3_Silent_p.K284K	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	320					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GGCTCTTCTTCTTGCTGTTGC	0.592													0	0	0	1	0	22	37										T	103868831	C	T	103868831	2	4	82	1	0	0	0	0	0	0	0	1	8695	912	32	1		1	LDB1	10	103868831	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	974780	103868831	31665916	255	24639										
LDB1	8861	broad.mit.edu	37	chr10	103869736	103869736	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gctgccggatgctgaagtgcCacgtctttatccgcatcatg	11	12	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:103869736C>T	uc009xwz.2	-	7	933	c.590G>A	c.(589-591)TGG>TAG	p.W197*	LDB1_uc001kuk.3_Nonsense_Mutation_p.W161*|LDB1_uc001kul.3_Nonsense_Mutation_p.W161*	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	197					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GCTGAAGTGCCACGTCTTTAT	0.602													0	0	0	1	0	18	38										T	103869736	C	T	103869736	4	4	82	1	0	0	0	0	0	1	0	0	8695	595	21	2	665	2	LDB1	10	103869736	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	905	103869736	31665011	256	24640										
ABLIM1	3983	broad.mit.edu	37	chr10	116307492	116307492	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cactgcttatccagcgccagCagcgcctgcccattcttgat	8	16	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:116307492C>T	uc010qsg.1	-	5	816	c.717G>A	c.(715-717)CTG>CTA	p.L239L	ABLIM1_uc010qsh.1_Silent_p.L179L|ABLIM1_uc010qsi.1_Silent_p.L179L|ABLIM1_uc010qsk.1_Silent_p.L163L|ABLIM1_uc009xyp.2_Silent_p.L173L|ABLIM1_uc009xyo.2_Silent_p.L87L	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	239	LIM zinc-binding 3.				axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CCAGCGCCAGCAGCGCCTGCC	0.552													0	0	0	1	0	12	19										T	116307492	C	T	116307492	2	4	82	1	0	0	0	0	0	0	0	1	94	697	25	2		2	ABLIM1	10	116307492	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	12437756	116307492	19227255	257	24641										
WDR11	55717	broad.mit.edu	37	chr10	122637962	122637962	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atgaacttcaactggttgatCttccaacaggtttgttttta	7	7	2	2	rs112914841		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:122637962C>T	uc010qtf.1	+	12	1892	c.1654C>T	c.(1654-1656)CTT>TTT	p.L552F	WDR11_uc010qte.1_Missense_Mutation_p.L154F|WDR11_uc001lfd.1_Missense_Mutation_p.L70F	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	552						integral to membrane					0						ACTGGTTGATCTTCCAACAGG	0.333													0	0	0	1	0	16	28										T	122637962	C	T	122637962	3	4	82	1	0	0	0	0	1	0	0	0	17270	913	32	1	1700	1	WDR11	10	122637962	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6330470	122637962	12896785	258	24642										
TACC2	10579	broad.mit.edu	37	chr10	123846157	123846157	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggagaggatgggagagccttCccaggacccaaagcagggca	16	10	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:123846157C>T	uc001lfv.2	+	4	4502	c.4142C>T	c.(4141-4143)TCC>TTC	p.S1381F	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.S1381F|TACC2_uc010qtv.1_Missense_Mutation_p.S1381F	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1381						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGAGAGCCTTCCCAGGACCCA	0.612													0	0	0	1	0	18	32										T	123846157	C	T	123846157	3	4	82	1	0	0	0	0	1	0	0	0	15499	855	30	1	4152	1	TACC2	10	123846157	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1208195	123846157	11688590	259	24643										
PSTK	118672	broad.mit.edu	37	chr10	124739930	124739930	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggcggcggagacgctgcgcGtgcgcgcagggcagacggta	20	11	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:124739930G>A	uc001lgy.1	+	1	375	c.-65G>A	c.(-67--63)GCGTG>GCATG			NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase								ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GACGCTGCGCGTGCGCGCAGG	0.692											OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	3										A	124739930	G	A	124739930	1	1	82	1	0	0	0	0	0	0	0	0	12720	1160	40	2		2	PSTK	10	124739930	Translation_Start_Site	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	893773	124739930	10794817	260	24644										
UROS	7390	broad.mit.edu	37	chr10	127486691	127486691	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaggtttccacagggaaataGaagaggcagtgctgaggact	15	6	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:127486691G>A	uc001liw.3	-	6	551	c.418C>T	c.(418-420)CTA>TTA	p.L140L	UROS_uc001liv.3_Silent_p.F19F|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Silent_p.L140L|UROS_uc001liy.3_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	140					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				CAGGGAAATAGAAGAGGCAGT	0.507													0	0	0	1	0	25	40										A	127486691	G	A	127486691	2	1	82	1	0	0	0	0	0	0	0	1	17027	933	33	1		1	UROS	10	127486691	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2746761	127486691	8048056	261	24645										
EBF3	253738	broad.mit.edu	37	chr10	131760444	131760444	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aactttctcacctgtttggtCattgaatctatgaggcgaac	8	9	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr10:131760444C>T	uc001lki.1	-	4	461	c.402G>A	c.(400-402)ATG>ATA	p.M134I	EBF3_uc010qur.1_3'UTR	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	134					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCTGTTTGGTCATTGAATCTA	0.488													0	0	0	1	0	16	35										T	131760444	C	T	131760444	3	4	82	1	0	0	0	0	1	0	0	0	4882	826	29	1	1305	1	EBF3	10	131760444	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4273753	131760444	3774303	262	24646										
HIPK3	10114	broad.mit.edu	37	chr11	33308756	33308756	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tacgagcttatgaatgctttCagcaccgtaaccatacttgt	7	10	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:33308756C>T	uc001mul.1	+	2	1066	c.796C>T	c.(796-798)CAG>TAG	p.Q266*	HIPK3_uc001mum.1_Nonsense_Mutation_p.Q266*|HIPK3_uc009yjv.1_Nonsense_Mutation_p.Q266*	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	266	Protein kinase.				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TGAATGCTTTCAGCACCGTAA	0.368													0	0	0	1	0	6	87										T	33308756	C	T	33308756	4	4	82	1	0	0	0	0	0	1	0	0	7118	827	29	1	798	1	HIPK3	11	33308756	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		33308756	101697760	263	24647										
C11orf41	25758	broad.mit.edu	37	chr11	33605015	33605015	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acaagaacgacttcaagcctGacaccatgataaacctgccg	7	13	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:33605015G>C	uc001mup.3	+	10	3785	c.3661G>C	c.(3661-3663)GAC>CAC	p.D1221H	C11orf41_uc001mun.1_Missense_Mutation_p.D1221H	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1215						integral to membrane				ovary(2)	2						CTTCAAGCCTGACACCATGAT	0.567													0	0	0	1	0	2	0										C	33605015	G	C	33605015	3	2	82	1	0	0	0	0	1	0	0	0	1640	1290	45	1	3699	1	C11orf41	11	33605015	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	296259	33605015	101401501	264	24648										
PAMR1	25891	broad.mit.edu	37	chr11	35492234	35492234	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acgtggagtgaggatcctatGctctggataggagctggccg	16	8	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:35492234G>A	uc001mwg.2	-	5	670	c.627C>T	c.(625-627)AGC>AGT	p.S209S	PAMR1_uc001mwf.2_Silent_p.S209S|PAMR1_uc010rew.1_Intron|PAMR1_uc010rex.1_Silent_p.S169S	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	209	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						AGGATCCTATGCTCTGGATAG	0.522													0	0	0	1	0	15	14										A	35492234	G	A	35492234	2	1	82	1	0	0	0	0	0	0	0	1	11413	1310	46	2		2	PAMR1	11	35492234	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1887219	35492234	99514282	265	24649										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57076110	57076110	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atgctccctggcttcacttgGagccccaaagagctccacat	8	15	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:57076110G>A	uc001njr.2	-	5	4387	c.4075C>T	c.(4075-4077)CCA>TCA	p.P1359S	TNKS1BP1_uc001njs.2_Missense_Mutation_p.P1359S|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.P810S	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1359	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GCTTCACTTGGAGCCCCAAAG	0.652													0	0	0	1	0	48	104										A	57076110	G	A	57076110	3	1	82	1	0	0	0	0	1	0	0	0	16317	1174	41	1	1138	1	TNKS1BP1	11	57076110	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	21583876	57076110	77930406	266	24650										
MS4A2	2206	broad.mit.edu	37	chr11	59861476	59861476	+	Frame_Shift_Del	DEL	C	C	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgtttctcaccattctgggaCttggtagtgctgtgtcactc					rs143436537	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:59861476delC	uc001nop.2	+	6	679	c.577delC	c.(577-579)CTTfs	p.L193fs	MS4A2_uc009ymu.2_3'UTR	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	193	Helical; (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	CATTCTGGGACTTGGTAGTGC	0.403																		8	36	---	---								-	59861476	C	-	59861476	7	5	82	1	0	1	0	1	0	0	0	0	9860	565	20	0	650	0	MS4A2	11	59861476	Frame_Shift_Del	DEL	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2785366	59861476	75145040	267	24651										
RAB3IL1	5866	broad.mit.edu	37	chr11	61672126	61672126	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cggcggcccgtaccagcaccGagagctgtggcagaccaggg	16	14	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:61672126G>A	uc001nso.2	-	7	949	c.791C>T	c.(790-792)TCG>TTG	p.S264L	RAB3IL1_uc001nsp.2_Missense_Mutation_p.S238L	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	264							protein binding			skin(2)|central_nervous_system(1)	3						TACCAGCACCGAGAGCTGTGG	0.692													0	0	0	1	0	3	10										A	61672126	G	A	61672126	3	1	82	1	0	0	0	0	1	0	0	0	12937	1059	37	1	373	1	RAB3IL1	11	61672126	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1810650	61672126	73334390	268	24652										
TUT1	64852	broad.mit.edu	37	chr11	62342673	62342673	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggtcacagtgagcattcggtCagccggggagacagacgcca	15	11	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:62342673C>T	uc001nto.2	-	9	2670	c.2632G>A	c.(2632-2634)GAC>AAC	p.D878N	EEF1G_uc001ntm.1_5'Flank|EEF1G_uc010rlw.1_5'Flank|EEF1G_uc001ntn.1_5'Flank|TUT1_uc001ntp.1_Missense_Mutation_p.D374N	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	840					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						AGCATTCGGTCAGCCGGGGAG	0.567													0	0	0	1	0	28	46										T	62342673	C	T	62342673	3	4	82	1	0	0	0	0	1	0	0	0	16777	826	29	1	110	1	TUT1	11	62342673	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	670547	62342673	72663843	269	24653										
ATL3	25923	broad.mit.edu	37	chr11	63398817	63398817	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctccagctcctgctggtaacGaaagctgaaatccttcccac	7	15	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:63398817G>C	uc001nxk.1	-	12	1510	c.1234C>G	c.(1234-1236)CGT>GGT	p.R412G	ATL3_uc010rms.1_Missense_Mutation_p.R394G|ATL3_uc010rmr.1_Missense_Mutation_p.R70G	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	atlastin 3	412	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			pancreas(1)	1						TGCTGGTAACGAAAGCTGAAA	0.463													0	0	0	1	0	39	60										C	63398817	G	C	63398817	3	2	82	1	0	0	0	0	1	0	0	0	1108	1058	37	1	399	1	ATL3	11	63398817	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1056144	63398817	71607699	270	24654										
CCDC88B	283234	broad.mit.edu	37	chr11	64119604	64119604	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttccctcctccatcctaggcCgagaagtctgtgctggagat	10	13	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:64119604C>G	uc001nzy.2	+	19	3146	c.3102C>G	c.(3100-3102)GCC>GCG	p.A1034A	CCDC88B_uc009ypo.1_Silent_p.A1031A|CCDC88B_uc001oaa.2_Silent_p.A186A|CCDC88B_uc001oab.1_5'Flank|CCDC88B_uc001oac.2_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1034	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						CATCCTAGGCCGAGAAGTCTG	0.667													0	0	0	1	0	16	20										G	64119604	C	G	64119604	2	3	82	1	0	0	0	0	0	0	0	1	2864	639	23	4		4	CCDC88B	11	64119604	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	720787	64119604	70886912	271	24655										
CARNS1	57571	broad.mit.edu	37	chr11	67190990	67190990	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gggctcgcggcctcaagctaGatggctgcttctcctactgg	13	13	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:67190990G>C	uc009yrp.2	+	9	1854	c.1402G>C	c.(1402-1404)GAT>CAT	p.D468H	PPP1CA_uc001okx.1_5'Flank|CARNS1_uc001olc.3_Missense_Mutation_p.D607H	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	468					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						CCTCAAGCTAGATGGCTGCTT	0.627													0	0	0	1	0	10	15										C	67190990	G	C	67190990	3	2	82	1	0	0	0	0	1	0	0	0	2656	942	33	1	1805	1	CARNS1	11	67190990	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3071386	67190990	67815526	272	24656										
SHANK2	22941	broad.mit.edu	37	chr11	70349010	70349010	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttcaccacctgcctgtggccGactttgacaacattctcatt	6	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:70349010G>A	uc001oqc.2	-	15	2166	c.2088C>T	c.(2086-2088)GTC>GTT	p.V696V	SHANK2_uc010rqn.1_Silent_p.V108V|SHANK2_uc001opz.2_Silent_p.V108V|uc009ysn.1_Intron|SHANK2_uc010rqp.1_Silent_p.V108V|SHANK2_uc001opy.2_5'Flank|SHANK2_uc010rqo.1_5'Flank	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	317	PDZ.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GCCTGTGGCCGACTTTGACAA	0.582													0	0	0	1	0	8	59										A	70349010	G	A	70349010	2	1	82	1	0	0	0	0	0	0	0	1	14265	1045	37	1		1	SHANK2	11	70349010	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3158020	70349010	64657506	273	24657										
DHCR7	1717	broad.mit.edu	37	chr11	71152464	71152464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agccaggcttgcaggccattGatctgatacttgttcacaac	9	11	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:71152464G>A	uc001oqk.2	-	6	685	c.435C>T	c.(433-435)ATC>ATT	p.I145I	DHCR7_uc001oql.2_Silent_p.I145I	NM_001163817	NP_001157289	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	145			I -> L (in SLOS).		cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			ovary(1)|liver(1)	2					NADH(DB00157)	GCAGGCCATTGATCTGATACT	0.552									Smith-Lemli-Opitz_syndrome				0	0	0	1	0	17	18										A	71152464	G	A	71152464	2	1	82	1	0	0	0	0	0	0	0	1	4477	1280	45	1		1	DHCR7	11	71152464	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	803454	71152464	63854052	274	24658										
MAP6	4135	broad.mit.edu	37	chr11	75298823	75298823	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gacaggtgctgggaccatagGagcttgattcttcacaggct	13	9	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:75298823G>A	uc001owu.2	-	4	1788	c.1723C>T	c.(1723-1725)CCT>TCT	p.P575S		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	575	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GGGACCATAGGAGCTTGATTC	0.502													0	0	0	1	0	59	100										A	75298823	G	A	75298823	3	1	82	1	0	0	0	0	1	0	0	0	9264	1174	41	1	722	1	MAP6	11	75298823	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4146359	75298823	59707693	275	24659										
CARD16	114769	broad.mit.edu	37	chr11	104912200	104912200	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taggatatagagatcctttaTgcaaggggagcagaagtatg	13	4	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:104912200T>C	uc001pip.1	-	3	548	c.521A>G	c.(520-522)CAT>CGT	p.H174R	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_3'UTR	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	174					regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						AGATCCTTTATGCAAGGGGAG	0.383													0	0	0	1	0	32	53										C	104912200	T	C	104912200	3	2	82	1	0	0	0	0	1	0	0	0	2647	1464	51	5	76	5	CARD16	11	104912200	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	29613377	104912200	30094316	276	24660										
ALKBH8	91801	broad.mit.edu	37	chr11	107427575	107427575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cattgagggtaacataggctCtcttagattcttctgtagtt	9	7	3	2	rs150490382		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:107427575C>T	uc010rvr.1	-	3	359	c.284G>A	c.(283-285)AGA>AAA	p.R95K	ALKBH8_uc010rvq.1_5'UTR|ALKBH8_uc009yxp.2_Missense_Mutation_p.R95K|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	95	RRM.				response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		AACATAGGCTCTCTTAGATTC	0.378													0	0	0	1	0	20	32										T	107427575	C	T	107427575	3	4	82	1	0	0	0	0	1	0	0	0	533	913	32	1	1750	1	ALKBH8	11	107427575	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2515375	107427575	27578941	277	24661										
C11orf65	160140	broad.mit.edu	37	chr11	108277655	108277655	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcttcaataggtctgtgagtAaaaatcttatagtatatatc	6	5	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:108277655A>G	uc001pkh.2	-	5	334	c.264T>C	c.(262-264)TTT>TTC	p.F88F	C11orf65_uc010rvx.1_Silent_p.F39F|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	88										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		GTCTGTGAGTAAAAATCTTAT	0.313													0	0	0	1	0	25	32										G	108277655	A	G	108277655	2	3	82	1	0	0	0	0	0	0	0	1	1655	359	13	5		5	C11orf65	11	108277655	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	850080	108277655	26728861	278	24662										
DIXDC1	85458	broad.mit.edu	37	chr11	111853158	111853158	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aacagctgttggaacaacaaGaatatttagaaaaagaaatg	8	4	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:111853158G>A	uc001pml.2	+	8	1162	c.865G>A	c.(865-867)GAA>AAA	p.E289K	DIXDC1_uc001pmm.2_Missense_Mutation_p.E78K|DIXDC1_uc001pmn.2_5'UTR	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	289	Potential.|Actin-binding.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		GGAACAACAAGAATATTTAGA	0.423											OREG0021331	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	8	13										A	111853158	G	A	111853158	3	1	82	1	0	0	0	0	1	0	0	0	4541	933	33	1	917	1	DIXDC1	11	111853158	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3575503	111853158	23153358	279	24663										
H2AFX	3014	broad.mit.edu	37	chr11	118965789	118965815	+	In_Frame_Del	DEL	CCTGGGCGATCGTCACGCCGCCCAGCA	CCTGGGCGATCGTCACGCCGCCCAGCA	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gatgttgggcaggacgcctcCctgggcgatcgtcacgccgc							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:118965789_118965815delCCTGGGCGATCGTCACGCCGCCCAGCA	uc001pvg.2	-	1	363_389	c.290_316delTGCTGGGCGGCGTGACGATCGCCCAGG	c.(289-318)CTGCTGGGCGGCGTGACGATCGCCCAGGGA>CGA	p.97_106LLGGVTIAQG>R	H2AFX_uc001pvh.1_RNA	NM_002105	NP_002096	P16104	H2AX_HUMAN	H2A histone family, member X	97_106					DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		AGGACGCCTCCCTGGGCGATCGTCACGCCGCCCAGCAGCTTGTTGAG	0.692								Chromatin_Structure|Direct_reversal_of_damage			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						16	76	---	---								-	118965815	CCTGGGCGATCGTCACGCCGCCCAGCA	-	118965789	7	5	82	1	0	1	0	1	0	0	0	0	6928	632	22	0	119	0	H2AFX	11	118965789	In_Frame_Del	DEL	CCTGGGCGATCGTCACGCCGCCCAGCA	TCGA-FD-A3SN-01A-12D-A22Z-08	7112631	118965789	16040727	280	24664										
CDON	50937	broad.mit.edu	37	chr11	125848278	125848278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggccgtgtacattccaccacCctggacaggaaggagtgtca	12	12	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:125848278C>T	uc009zbw.2	-	18	3405	c.3277G>A	c.(3277-3279)GGT>AGT	p.G1093S	CDON_uc001qdb.3_Missense_Mutation_p.G470S|CDON_uc001qdc.3_Missense_Mutation_p.G1093S	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	1093	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ATTCCACCACCCTGGACAGGA	0.443													0	0	0	1	0	4	10										T	125848278	C	T	125848278	3	4	82	1	0	0	0	0	1	0	0	0	3170	637	22	2	529	2	CDON	11	125848278	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6882489	125848278	9158238	281	24665										
KCNJ1	3758	broad.mit.edu	37	chr11	128709869	128709869	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcagaaggatggaattccggGaggtctttgtgaatgtacgc	15	6	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:128709869G>A	uc001qeo.1	-	2	378	c.327C>T	c.(325-327)CTC>CTT	p.L109L	KCNJ1_uc001qep.1_Silent_p.L90L|KCNJ1_uc001qeq.1_Silent_p.L90L|KCNJ1_uc001qer.1_Silent_p.L90L|KCNJ1_uc001qes.1_Silent_p.L90L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	109	Extracellular (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	GGAATTCCGGGAGGTCTTTGT	0.448													0	0	0	1	0	42	68										A	128709869	G	A	128709869	2	1	82	1	0	0	0	0	0	0	0	1	8043	1161	41	1		1	KCNJ1	11	128709869	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2861591	128709869	6296647	282	24666										
ST14	6768	broad.mit.edu	37	chr11	130066285	130066285	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcaaattcttctacctgctgGagcccggcgtgcctgcgggc	12	14	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr11:130066285G>T	uc001qfw.2	+	10	1358	c.1165G>T	c.(1165-1167)GAG>TAG	p.E389*	ST14_uc010sca.1_Nonsense_Mutation_p.E199*	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	389	CUB 2.|Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CTACCTGCTGGAGCCCGGCGT	0.637													1	0	1.23904e-05	1	1.25394e-05	4	11										T	130066285	G	T	130066285	4	4	82	1	0	0	0	0	0	1	0	0	15210	1175	41	3	1203	3	ST14	11	130066285	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1356416	130066285	4940231	283	24667										
NRIP2	83714	broad.mit.edu	37	chr12	2944131	2944131	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gggtctccacgggagggaaaGaggaaaaataaataacatgc	13	6	1	1	rs146664830		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:2944131G>C	uc001qlc.2	-	1	91	c.19C>G	c.(19-21)CTT>GTT	p.L7V	NRIP2_uc010sed.1_Missense_Mutation_p.L7V|uc009zdz.1_5'Flank	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	7					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GGGAGGGAAAGAGGAAAAATA	0.562													0	0	0	1	0	15	23										C	2944131	G	C	2944131	3	2	82	1	0	0	0	0	1	0	0	0	10653	942	33	1	850	1	NRIP2	12	2944131	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		2944131	130907764	284	24668										
VWF	7450	broad.mit.edu	37	chr12	6161924	6161924	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggggtcccgcactgcaggtaCacctggcctttcgggcagtt	14	13	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:6161924C>T	uc001qnn.1	-	16	2221	c.1971G>A	c.(1969-1971)GTG>GTA	p.V657V	VWF_uc010set.1_Silent_p.V657V	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	657	TIL 2.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	ACTGCAGGTACACCTGGCCTT	0.597													0	0	0	1	0	11	26										T	6161924	C	T	6161924	2	4	82	1	0	0	0	0	0	0	0	1	17243	465	17	2		2	VWF	12	6161924	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3217793	6161924	127689971	285	24669										
C1RL	51279	broad.mit.edu	37	chr12	7254567	7254567	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tccgaggaaggctgtgtgcgGaaggtcagccgcaaactcct	14	11	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:7254567G>A	uc001qsn.2	-	3	434	c.417C>T	c.(415-417)TTC>TTT	p.F139F	C1RL_uc009zft.2_Silent_p.F139F|C1RL_uc001qso.1_Silent_p.F139F	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	139	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						GCTGTGTGCGGAAGGTCAGCC	0.627													0	0	0	1	0	50	76										A	7254567	G	A	7254567	2	1	82	1	0	0	0	0	0	0	0	1	1973	1165	41	1		1	C1RL	12	7254567	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1092643	7254567	126597328	286	24670										
DUSP16	80824	broad.mit.edu	37	chr12	12630261	12630261	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gctcccacttcgatgcagtgGagataaaagggacctctggg	13	10	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:12630261G>C	uc001rao.1	-	7	2136	c.1504C>G	c.(1504-1506)CCA>GCA	p.P502A	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.P354A	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	502					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CGATGCAGTGGAGATAAAAGG	0.587													0	0	0	1	0	37	58										C	12630261	G	C	12630261	3	2	82	1	0	0	0	0	1	0	0	0	4816	1174	41	1	497	1	DUSP16	12	12630261	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	5375694	12630261	121221634	287	24671										
PDE3A	5139	broad.mit.edu	37	chr12	20523043	20523043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gagcatttggggtcccagctGattgctgggaccaaggaaga	15	8	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:20523043G>A	uc001reh.1	+	1	847	c.825G>A	c.(823-825)CTG>CTA	p.L275L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627													0	0	0	1	0	17	29										A	20523043	G	A	20523043	2	1	82	1	0	0	0	0	0	0	0	1	11637	1277	45	1		1	PDE3A	12	20523043	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7892782	20523043	113328852	288	24672										
OVCH1	341350	broad.mit.edu	37	chr12	29639199	29639199	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ataccctttcctctctggctTccattcacttcttggacaga	5	14	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:29639199T>G	uc001rix.1	-	8	975	c.975A>C	c.(973-975)GGA>GGC	p.G325G		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	325	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					CTCTCTGGCTTCCATTCACTT	0.443													0	0	0	1	0	21	31										G	29639199	T	G	29639199	2	3	82	1	0	0	0	0	0	0	0	1	11323	1770	62	5		5	OVCH1	12	29639199	Silent	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	9116156	29639199	104212696	289	24673										
CAPRIN2	65981	broad.mit.edu	37	chr12	30881858	30881858	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttctttggatcttgttctttCtgcagctgaactggccacag	9	10	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:30881858C>T	uc001rji.1	-	8	2257	c.1506G>A	c.(1504-1506)CAG>CAA	p.Q502Q	CAPRIN2_uc001rjf.1_Silent_p.Q299Q|CAPRIN2_uc001rjg.1_Silent_p.Q169Q|CAPRIN2_uc001rjh.1_Silent_p.Q502Q|CAPRIN2_uc001rjj.1_Silent_p.Q169Q|CAPRIN2_uc001rjk.3_Silent_p.Q502Q|CAPRIN2_uc001rjl.3_Silent_p.Q502Q|CAPRIN2_uc001rjm.1_Silent_p.Q169Q|CAPRIN2_uc001rjn.1_Silent_p.Q169Q	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	502					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CTTGTTCTTTCTGCAGCTGAA	0.473													0	0	0	1	0	55	75										T	30881858	C	T	30881858	2	4	82	1	0	0	0	0	0	0	0	1	2636	912	32	1		1	CAPRIN2	12	30881858	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1242659	30881858	102970037	290	24674										
ARID2	196528	broad.mit.edu	37	chr12	46244139	46244139	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctccacagagttctgttgttCagaatcatagtacagggcca	9	10	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:46244139C>T	uc001ros.1	+	15	2233	c.2233C>T	c.(2233-2235)CAG>TAG	p.Q745*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q745*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q201*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q372*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q79*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	745					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCTGTTGTTCAGAATCATAG	0.443													0	0	0	1	0	41	51										T	46244139	C	T	46244139	4	4	82	1	0	0	0	0	0	1	0	0	915	827	29	1	2291	1	ARID2	12	46244139	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	15362281	46244139	87607756	291	24675										
RND1	27289	broad.mit.edu	37	chr12	49255809	49255809	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taccttcttgagtgcgctgtCcactgtctctggacggctga	11	12	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:49255809C>T	uc001rsn.2	-	3	404	c.301G>A	c.(301-303)GAC>AAC	p.D101N		NM_014470	NP_055285	Q92730	RND1_HUMAN	GTP-binding protein RHO6 precursor	101					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			ovary(1)	1						AGTGCGCTGTCCACTGTCTCT	0.448													0	0	0	1	0	24	28										T	49255809	C	T	49255809	3	4	82	1	0	0	0	0	1	0	0	0	13419	855	30	1	409	1	RND1	12	49255809	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3011670	49255809	84596086	292	24676										
PRPF40B	25766	broad.mit.edu	37	chr12	50036434	50036434	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcggagcggatccggctcttCcgggagttcctacaggtgct	14	12	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:50036434C>T	uc001rur.1	+	20	2092	c.2028C>T	c.(2026-2028)TTC>TTT	p.F676F	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Silent_p.F698F|PRPF40B_uc001ruq.1_Silent_p.F663F|PRPF40B_uc001rus.1_Silent_p.F619F|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	676					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						TCCGGCTCTTCCGGGAGTTCC	0.567													0	0	0	1	0	16	22										T	50036434	C	T	50036434	2	4	82	1	0	0	0	0	0	0	0	1	12572	854	30	1		1	PRPF40B	12	50036434	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	780625	50036434	83815461	293	24677										
RARG	5916	broad.mit.edu	37	chr12	53607432	53607432	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggttcagggtcagcccgtcgGagaaggtcatggtgtcctgc	16	10	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:53607432G>A	uc001sce.2	-	8	1351	c.866C>T	c.(865-867)TCC>TTC	p.S289F	RARG_uc001scd.2_Missense_Mutation_p.S278F|RARG_uc010sob.1_Missense_Mutation_p.S267F|RARG_uc001scf.2_Missense_Mutation_p.S289F|RARG_uc001scg.2_Missense_Mutation_p.S217F|RARG_uc010soc.1_Missense_Mutation_p.S168F|RARG_uc010sod.1_Missense_Mutation_p.S326F	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	289	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CAGCCCGTCGGAGAAGGTCAT	0.622											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	38										A	53607432	G	A	53607432	3	1	82	1	0	0	0	0	1	0	0	0	13054	1174	41	1	510	1	RARG	12	53607432	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3570998	53607432	80244463	294	24678										
RARG	5916	broad.mit.edu	37	chr12	53607867	53607867	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atatctaggcaggcagctttGagcagagtgatctggtcagc	13	8	3	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:53607867G>C	uc001sce.2	-	7	1274	c.789C>G	c.(787-789)CTC>CTG	p.L263L	RARG_uc001scd.2_Silent_p.L252L|RARG_uc010sob.1_Silent_p.L241L|RARG_uc001scf.2_Silent_p.L263L|RARG_uc001scg.2_Silent_p.L191L|RARG_uc010soc.1_Silent_p.L142L|RARG_uc010sod.1_Silent_p.L300L	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	263	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AGGCAGCTTTGAGCAGAGTGA	0.532											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	66	136										C	53607867	G	C	53607867	2	2	82	1	0	0	0	0	0	0	0	1	13054	1277	45	1		1	RARG	12	53607867	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	435	53607867	80244028	295	24679										
SMUG1	23583	broad.mit.edu	37	chr12	54576210	54576210	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcagagggcatagattgtgGacaaaacagtgatggaagaa	14	4	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:54576210G>C	uc001sff.1	-	4	612	c.483C>G	c.(481-483)GTC>GTG	p.V161V	SMUG1_uc001sfa.1_5'Flank|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Silent_p.V161V|SMUG1_uc009znf.1_Silent_p.V161V|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	161				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						ATAGATTGTGGACAAAACAGT	0.562								BER_DNA_glycosylases					0	0	0	1	0	34	74										C	54576210	G	C	54576210	2	2	82	1	0	0	0	0	0	0	0	1	14818	1161	41	1		1	SMUG1	12	54576210	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	968343	54576210	79275685	296	24680										
ERBB3	2065	broad.mit.edu	37	chr12	56490853	56490853	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgctggccattggcagcctgGaccatgcccacattgtaagg	12	12	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:56490853G>A	uc001sjh.2	+	20	2492	c.2299G>A	c.(2299-2301)GAC>AAC	p.D767N	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Missense_Mutation_p.D124N|ERBB3_uc010sqc.1_Missense_Mutation_p.D708N|ERBB3_uc009zok.2_Intron|ERBB3_uc001sjk.2_Missense_Mutation_p.D8N	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	767	Cytoplasmic (Potential).|Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TGGCAGCCTGGACCATGCCCA	0.512													0	0	0	1	0	29	35										A	56490853	G	A	56490853	3	1	82	1	0	0	0	0	1	0	0	0	5208	1174	41	1	2508	1	ERBB3	12	56490853	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1914643	56490853	77361042	297	24681										
ANKRD52	283373	broad.mit.edu	37	chr12	56637606	56637606	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agcactgtggccccatgactCagcagggcctgtaccacaga	11	14	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:56637606C>T	uc001skm.3	-	27	3033	c.2943G>A	c.(2941-2943)CTG>CTA	p.L981L		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	981	ANK 28.						protein binding			ovary(2)	2						CCCCATGACTCAGCAGGGCCT	0.567													0	0	0	1	0	4	0										T	56637606	C	T	56637606	2	4	82	1	0	0	0	0	0	0	0	1	678	813	29	1		1	ANKRD52	12	56637606	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	146753	56637606	77214289	298	24682										
STAC3	246329	broad.mit.edu	37	chr12	57637672	57637672	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttgacgtagccgcccgcttCgtctcctttctgcaccacga	8	17	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:57637672C>T	uc001snp.2	-	12	1213	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K	STAC3_uc009zpl.2_Missense_Mutation_p.R57Q|STAC3_uc001snq.2_Missense_Mutation_p.E301K|STAC3_uc010srm.1_Missense_Mutation_p.E154K	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	340	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						CCGCCCGCTTCGTCTCCTTTC	0.562											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	4	16										T	57637672	C	T	57637672	3	4	82	1	0	0	0	0	1	0	0	0	15240	893	31	1	80	1	STAC3	12	57637672	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1000066	57637672	76214223	299	24683										
ARHGAP9	64333	broad.mit.edu	37	chr12	57870952	57870952	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atctcacctgtgggtcaagcGgttctggggtccctgtgtca	13	11	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:57870952G>A	uc001sod.2	-	8	1263	c.1070C>T	c.(1069-1071)CCG>CTG	p.P357L	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.P102L|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Missense_Mutation_p.P286L|ARHGAP9_uc001soc.2_Missense_Mutation_p.P286L|ARHGAP9_uc001soe.1_Missense_Mutation_p.P365L|ARHGAP9_uc010sro.1_Missense_Mutation_p.P286L	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	286					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGGGTCAAGCGGTTCTGGGGT	0.522													0	0	0	1	0	21	41										A	57870952	G	A	57870952	3	1	82	1	0	0	0	0	1	0	0	0	889	1116	39	2	1394	2	ARHGAP9	12	57870952	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	233280	57870952	75980943	300	24684										
GNS	2799	broad.mit.edu	37	chr12	65130795	65130795	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcacctaccttgcttgtctGatttggtttgatcccaggtc	10	11	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:65130795G>C	uc001ssg.3	-	9	1257	c.1087C>G	c.(1087-1089)CAG>GAG	p.Q363E	GNS_uc001ssf.2_Missense_Mutation_p.Q307E|GNS_uc010ssq.1_Missense_Mutation_p.Q395E|GNS_uc010ssr.1_Missense_Mutation_p.Q343E	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	363						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		TTGCTTGTCTGATTTGGTTTG	0.453													0	0	0	1	0	14	27										C	65130795	G	C	65130795	3	2	82	1	0	0	0	0	1	0	0	0	6550	1299	45	1	595	1	GNS	12	65130795	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7259843	65130795	68721100	301	24685										
ZFC3H1	196441	broad.mit.edu	37	chr12	72024481	72024481	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ataactgttttcggctaagtGtatagtcttgtatatgctgc	9	6	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:72024481G>C	uc001swo.2	-	18	3982	c.3623C>G	c.(3622-3624)ACA>AGA	p.T1208R		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1208					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TCGGCTAAGTGTATAGTCTTG	0.318													0	0	0	1	0	14	30										C	72024481	G	C	72024481	3	2	82	1	0	0	0	0	1	0	0	0	17630	1377	48	4	2418	4	ZFC3H1	12	72024481	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6893686	72024481	61827414	302	24686										
C12orf26	84190	broad.mit.edu	37	chr12	82752565	82752565	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggagacggaggccctgccctCagagacgcgccccctagtgg	15	15	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:82752565C>T	uc001szq.2	+	1	242	c.221C>T	c.(220-222)TCA>TTA	p.S74L	CCDC59_uc001szp.3_5'Flank	NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	74											0						GCCCTGCCCTCAGAGACGCGC	0.662											OREG0022008	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	23	38										T	82752565	C	T	82752565	3	4	82	1	0	0	0	0	1	0	0	0	1679	838	29	1	223	1	C12orf26	12	82752565	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	10728084	82752565	51099330	303	24687										
UHRF1BP1L	23074	broad.mit.edu	37	chr12	100452766	100452766	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttcaagagcttcttccgcttCaatcggccagccagatcact	7	14	4	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:100452766C>T	uc001tgq.2	-	14	2518	c.2289G>A	c.(2287-2289)TTG>TTA	p.L763L	UHRF1BP1L_uc001tgp.2_Silent_p.L413L	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	763										ovary(2)	2						TCTTCCGCTTCAATCGGCCAG	0.403													0	0	0	1	0	47	59										T	100452766	C	T	100452766	2	4	82	1	0	0	0	0	0	0	0	1	16966	825	29	1		1	UHRF1BP1L	12	100452766	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	17700201	100452766	33399129	304	24688										
CHPT1	56994	broad.mit.edu	37	chr12	102107962	102107962	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acaagccagaagaacaaactCttgttcccctttaggggagc	9	11	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:102107962C>T	uc001tin.2	+	2	591	c.368C>T	c.(367-369)TCT>TTT	p.S123F	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.S123F	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	123					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						AGAACAAACTCTTGTTCCCCT	0.378													0	0	0	1	0	37	95										T	102107962	C	T	102107962	3	4	82	1	0	0	0	0	1	0	0	0	3370	913	32	1	374	1	CHPT1	12	102107962	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1655196	102107962	31743933	305	24689										
CKAP4	10970	broad.mit.edu	37	chr12	106633728	106633728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttggctgaggtctgtatctCcttcacagcttcctttaagg	9	11	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:106633728C>T	uc001tlk.2	-	2	967	c.883G>A	c.(883-885)GAG>AAG	p.E295K		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	295	Potential.					ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0						GTCTGTATCTCCTTCACAGCT	0.517													0	0	0	1	0	35	86										T	106633728	C	T	106633728	3	4	82	1	0	0	0	0	1	0	0	0	3444	864	30	1	929	1	CKAP4	12	106633728	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4525766	106633728	27218167	306	24690										
ALKBH2	121642	broad.mit.edu	37	chr12	109530580	109530580	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccttgagcccctttcaccagGaatctgtccatcctgtcccc	6	18	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:109530580G>A	uc001tnx.2	-	2	405	c.12C>T	c.(10-12)TTC>TTT	p.F4F	ALKBH2_uc001tny.2_Silent_p.F4F|ALKBH2_uc010sxj.1_Silent_p.F4F|ALKBH2_uc009zvd.2_Silent_p.F4F|ALKBH2_uc010sxk.1_Silent_p.F4F	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	4					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	CTTTCACCAGGAATCTGTCCA	0.522								Direct_reversal_of_damage					0	0	0	1	0	39	83										A	109530580	G	A	109530580	2	1	82	1	0	0	0	0	0	0	0	1	527	1165	41	1		1	ALKBH2	12	109530580	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2896852	109530580	24321315	307	24691										
ATXN2	6311	broad.mit.edu	37	chr12	111951193	111951193	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgatgaccacgttccccccGagggactggtccttgctact	10	15	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:111951193G>A	uc001tsj.2	-	11	2168	c.2006C>T	c.(2005-2007)TCG>TTG	p.S669L	ATXN2_uc001tsh.2_Missense_Mutation_p.S404L|ATXN2_uc001tsi.2_Missense_Mutation_p.S380L|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsm.1_Missense_Mutation_p.S404L	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	669	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						CGTTCCCCCCGAGGGACTGGT	0.512													0	0	0	1	0	19	32										A	111951193	G	A	111951193	3	1	82	1	0	0	0	0	1	0	0	0	1211	1059	37	1	1995	1	ATXN2	12	111951193	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2420613	111951193	21900702	308	24692										
DTX1	1840	broad.mit.edu	37	chr12	113515257	113515257	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cggcccgtgcggcgcaacttCtacgacccgtcgtcggcgcc	13	18	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:113515257C>T	uc001tuk.1	+	2	624	c.288C>T	c.(286-288)TTC>TTT	p.F96F		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	96	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GGCGCAACTTCTACGACCCGT	0.672													0	0	0	1	0	13	26										T	113515257	C	T	113515257	2	4	82	1	0	0	0	0	0	0	0	1	4793	912	32	1		1	DTX1	12	113515257	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1564064	113515257	20336638	309	24693										
VPS37B	79720	broad.mit.edu	37	chr12	123353041	123353041	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctttacctcagtgtcttcctCaatcttggccccttctgcct	5	16	5	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:123353041C>G	uc001udl.2	-	3	455	c.352G>C	c.(352-354)GAG>CAG	p.E118Q		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	118	VPS37 C-terminal.|Interaction with IST1.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		GTGTCTTCCTCAATCTTGGCC	0.557													0	0	0	1	0	4	14										G	123353041	C	G	123353041	3	3	82	1	0	0	0	0	1	0	0	0	17203	835	29	1	513	1	VPS37B	12	123353041	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	9837784	123353041	10498854	310	24694										
PIWIL1	9271	broad.mit.edu	37	chr12	130839176	130839176	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggggacactgccagggcctgCcatgctcattcctgagctct	12	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr12:130839176C>G	uc001uik.2	+	10	1229	c.1139C>G	c.(1138-1140)GCC>GGC	p.A380G	PIWIL1_uc001uij.1_Missense_Mutation_p.A380G	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	380	PAZ.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		CCAGGGCCTGCCATGCTCATT	0.537													0	0	0	1	0	36	79										G	130839176	C	G	130839176	3	3	82	1	0	0	0	0	1	0	0	0	11957	739	26	4	1173	4	PIWIL1	12	130839176	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7486135	130839176	3012719	311	24695										
THSD1	55901	broad.mit.edu	37	chr13	52952424	52952424	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggccgcatcaatggcagtgtCtgtcaggggactctgagaca	14	10	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:52952424C>G	uc001vgo.2	-	5	2226	c.1681G>C	c.(1681-1683)GAC>CAC	p.D561H	THSD1_uc001vgp.2_Missense_Mutation_p.D508H|THSD1_uc010tgz.1_Missense_Mutation_p.D182H|THSD1_uc010aea.2_Missense_Mutation_p.D22H	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	561	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		ATGGCAGTGTCTGTCAGGGGA	0.522													0	0	0	1	0	72	30										G	52952424	C	G	52952424	3	3	82	1	0	0	0	0	1	0	0	0	15874	913	32	1	881	1	THSD1	13	52952424	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		52952424	62217454	312	24696										
SLITRK5	26050	broad.mit.edu	37	chr13	88328436	88328436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggtgggggatgtagtttgtGagacccccttccgcttacac	13	10	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:88328436G>A	uc001vln.2	+	2	1012	c.793G>A	c.(793-795)GAG>AAG	p.E265K	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	265	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TGTAGTTTGTGAGACCCCCTT	0.512													0	0	0	1	0	38	61										A	88328436	G	A	88328436	3	1	82	1	0	0	0	0	1	0	0	0	14746	1291	45	1	795	1	SLITRK5	13	88328436	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	35376012	88328436	26841442	313	24697										
GPC5	2262	broad.mit.edu	37	chr13	92345823	92345823	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aatctgggcattgaagtcatCaacaccacagactatctgca	7	11	4	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:92345823C>G	uc010tif.1	+	3	1074	c.708C>G	c.(706-708)ATC>ATG	p.I236M		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	236						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TTGAAGTCATCAACACCACAG	0.532													0	0	0	1	0	24	40										G	92345823	C	G	92345823	3	3	82	1	0	0	0	0	1	0	0	0	6601	816	29	1	718	1	GPC5	13	92345823	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4017387	92345823	22824055	314	24698										
DOCK9	23348	broad.mit.edu	37	chr13	99532219	99532219	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtacatcaaagaaaaaccatGagtactaaaagaaaaaagaa	6	5	1	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:99532219G>A	uc001vnt.2	-	27	2934	c.2879C>T	c.(2878-2880)TCA>TTA	p.S960L	DOCK9_uc001vnw.2_Missense_Mutation_p.S959L|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.S960L|DOCK9_uc010tis.1_Missense_Mutation_p.S959L|DOCK9_uc010tit.1_Missense_Mutation_p.S960L|DOCK9_uc010afu.1_Missense_Mutation_p.S806L	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	960					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GAAAAACCATGAGTACTAAAA	0.239													0	0	0	1	0	15	29										A	99532219	G	A	99532219	3	1	82	1	0	0	0	0	1	0	0	0	4694	1294	45	1	3511	1	DOCK9	13	99532219	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7186396	99532219	15637659	315	24699										
ERCC5	2073	broad.mit.edu	37	chr13	103468829	103468829	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aacttcagataaaaagggaaGatatcagaaggaatgtcctc	9	6	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:103468829G>A	uc001vpu.1	+	2	652	c.530G>A	c.(529-531)AGA>AAA	p.R177K	BIVM_uc001vps.2_Missense_Mutation_p.R177K|BIVM_uc010agc.2_5'UTR|BIVM_uc001vpt.2_Missense_Mutation_p.R177K	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	Error:Variant_position_missing_in_P28715_after_alignment					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAAAAGGGAAGATATCAGAAG	0.328			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	21	30										A	103468829	G	A	103468829	3	1	82	1	0	0	0	0	1	0	0	0	5216	942	33	1		1	ERCC5	13	103468829	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3936610	103468829	11701049	316	24700										
MYO16	23026	broad.mit.edu	37	chr13	109507866	109507866	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atgatggcagcctgctctatGagattcagaagcgctttggg	13	8	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:109507866G>A	uc001vqt.1	+	11	1384	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	MYO16_uc010agk.1_Missense_Mutation_p.E442K|MYO16_uc001vqu.1_Missense_Mutation_p.E220K	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	420	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCTGCTCTATGAGATTCAGAA	0.478													0	0	0	1	0	14	13										A	109507866	G	A	109507866	3	1	82	1	0	0	0	0	1	0	0	0	10064	1291	45	1	1296	1	MYO16	13	109507866	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6039037	109507866	5662012	317	24701										
CARS2	79587	broad.mit.edu	37	chr13	111357910	111357910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gatcatatacagttggtccaCagctatacctggaaacaaag	8	9	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr13:111357910C>T	uc001vrd.2	-	2	273	c.233G>A	c.(232-234)TGT>TAT	p.C78Y	CARS2_uc010tjm.1_Intron	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	78		Zinc (By similarity).			cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	AGTTGGTCCACAGCTATACCT	0.353													0	0	0	1	0	12	29										T	111357910	C	T	111357910	3	4	82	1	0	0	0	0	1	0	0	0	2658	478	17	2	1517	2	CARS2	13	111357910	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1850044	111357910	3811968	318	24702										
HEATR5A	25938	broad.mit.edu	37	chr14	31782285	31782285	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagatctgcatagactaagtCaagcagtccatctgatgaac	8	9	3	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:31782285C>T	uc001wrf.3	-	22	3528	c.3451G>A	c.(3451-3453)GAC>AAC	p.D1151N	HEATR5A_uc010ami.2_Missense_Mutation_p.D1049N	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1438							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		TAGACTAAGTCAAGCAGTCCA	0.428													0	0	0	1	0	37	30										T	31782285	C	T	31782285	3	4	82	1	0	0	0	0	1	0	0	0	7031	826	29	1	1846	1	HEATR5A	14	31782285	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		31782285	75567255	319	24703										
ARHGAP5	394	broad.mit.edu	37	chr14	32624002	32624002	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agtttttcttttacaatggaGaaattgtagaaacgacaaac	7	5	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:32624002G>A	uc001wrl.2	+	7	4596	c.4357G>A	c.(4357-4359)GAA>AAA	p.E1453K	ARHGAP5_uc001wrm.2_Missense_Mutation_p.E1452K|ARHGAP5_uc001wrn.2_Missense_Mutation_p.E1453K|ARHGAP5_uc001wro.2_Missense_Mutation_p.E192K|ARHGAP5_uc001wrp.2_Missense_Mutation_p.E188K	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1453					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTACAATGGAGAAATTGTAGA	0.418													0	0	0	1	0	26	11										A	32624002	G	A	32624002	3	1	82	1	0	0	0	0	1	0	0	0	886	943	33	1	4379	1	ARHGAP5	14	32624002	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	841717	32624002	74725538	320	24704										
C14orf135	64430	broad.mit.edu	37	chr14	60591527	60591527	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acgatctttacaaagcagttCtattaggataccctgctgtt	7	9	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:60591527C>G	uc001xer.3	+	8	2458	c.1936C>G	c.(1936-1938)CTA>GTA	p.L646V	C14orf135_uc001xeq.2_Missense_Mutation_p.L646V|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	880						integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		CAAAGCAGTTCTATTAGGATA	0.408													0	0	0	1	0	67	52										G	60591527	C	G	60591527	3	3	82	1	0	0	0	0	1	0	0	0	1745	912	32	1	1962	1	C14orf135	14	60591527	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	27967525	60591527	46758013	321	24705										
HIF1A	3091	broad.mit.edu	37	chr14	62200933	62200933	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gatatgtctgggttgaaactCaagcaactgtcatatataac	8	7	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:62200933C>T	uc001xfq.2	+	8	1362	c.958C>T	c.(958-960)CAA>TAA	p.Q320*	HIF1A_uc001xfr.2_Nonsense_Mutation_p.Q320*|HIF1A_uc001xfs.2_Nonsense_Mutation_p.Q321*	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	320	Interaction with TSGA10 (By similarity).|PAC.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		GGTTGAAACTCAAGCAACTGT	0.383													0	0	0	1	0	19	5										T	62200933	C	T	62200933	4	4	82	1	0	0	0	0	0	1	0	0	7103	827	29	1	988	1	HIF1A	14	62200933	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1609406	62200933	45148607	322	24706										
SYNE2	23224	broad.mit.edu	37	chr14	64453240	64453240	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taaaagtggctaaagatgttGaaaaactcattggacaagtg	10	4	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:64453240G>A	uc001xgm.2	+	19	2448	c.2218G>A	c.(2218-2220)GAA>AAA	p.E740K	SYNE2_uc001xgl.2_Missense_Mutation_p.E740K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	740	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TAAAGATGTTGAAAAACTCAT	0.388													0	0	0	1	0	14	24										A	64453240	G	A	64453240	3	1	82	1	0	0	0	0	1	0	0	0	15443	1291	45	1	2288	1	SYNE2	14	64453240	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2252307	64453240	42896300	323	24707										
ZFYVE26	23503	broad.mit.edu	37	chr14	68238913	68238913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttcccttagactaggggaatGtatactggagatacctggga	12	7	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:68238913G>A	uc001xka.2	-	28	5474	c.5335C>T	c.(5335-5337)CAT>TAT	p.H1779Y	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.H1779Y	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1779					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTAGGGGAATGTATACTGGAG	0.428													0	0	0	1	0	8	3										A	68238913	G	A	68238913	3	1	82	1	0	0	0	0	1	0	0	0	17665	1377	48	2	2344	2	ZFYVE26	14	68238913	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3785673	68238913	39110627	324	24708										
ZFYVE1	53349	broad.mit.edu	37	chr14	73444931	73444931	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acactgacttcctcgcctctCtcatagcaggcctgaaacag	7	15	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:73444931C>T	uc001xnm.2	-	7	2071	c.1431G>A	c.(1429-1431)GAG>GAA	p.E477E	ZFYVE1_uc001xnl.2_Silent_p.E62E|ZFYVE1_uc010arj.2_Silent_p.E477E	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	477						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CCTCGCCTCTCTCATAGCAGG	0.363													0	0	0	1	0	22	18										T	73444931	C	T	73444931	2	4	82	1	0	0	0	0	0	0	0	1	17660	912	32	1		1	ZFYVE1	14	73444931	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5206018	73444931	33904609	325	24709										
FOS	2353	broad.mit.edu	37	chr14	75747770	75747770	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtcaagagcatcagcagcatGgagctgaagaccgagccctt	12	11	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:75747770G>T	uc001xrn.2	+	4	991	c.786G>T	c.(784-786)ATG>ATT	p.M262I	FOS_uc010tva.1_Missense_Mutation_p.M226I|FOS_uc010asi.2_Missense_Mutation_p.M148I|FOS_uc001xro.2_Missense_Mutation_p.M114I	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene	262					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		TCAGCAGCATGGAGCTGAAGA	0.597													1	0	3.62531e-18	1	3.80625e-18	37	28										T	75747770	G	T	75747770	3	4	82	1	0	0	0	0	1	0	0	0	5985	1348	47	4	800	4	FOS	14	75747770	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2302839	75747770	31601770	326	24710										
FLVCR2	55640	broad.mit.edu	37	chr14	76107307	76107307	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctggtcttcagcttctttatGactggctatctcccactggg	9	12	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:76107307G>A	uc001xrs.2	+	7	1621	c.1245G>A	c.(1243-1245)ATG>ATA	p.M415I	FLVCR2_uc010tvd.1_Missense_Mutation_p.M210I	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	415	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		GCTTCTTTATGACTGGCTATC	0.522													0	0	0	1	0	14	20										A	76107307	G	A	76107307	3	1	82	1	0	0	0	0	1	0	0	0	5946	1290	45	1	1271	1	FLVCR2	14	76107307	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	359537	76107307	31242233	327	24711										
ADCK1	57143	broad.mit.edu	37	chr14	78325484	78325484	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaccggggcaccttcatcaaGgtgggccagcacctgggggc	15	13	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:78325484G>A	uc001xui.2	+	4	384	c.285G>A	c.(283-285)AAG>AAA	p.K95K	ADCK1_uc010tvo.1_RNA|ADCK1_uc001xuj.2_Intron|ADCK1_uc001xuk.1_5'UTR	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	102						extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		CCTTCATCAAGGTGGGCCAGC	0.617													0	0	0	1	0	28	27										A	78325484	G	A	78325484	2	1	82	1	0	0	0	0	0	0	0	1	288	991	35	2		2	ADCK1	14	78325484	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2218177	78325484	29024056	328	24712										
PTPN21	11099	broad.mit.edu	37	chr14	88974366	88974366	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttgcagataatactgataccTataaaaaatgtcagttgtat	6	5	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:88974366T>C	uc001xwv.3	-	4	682	c.351_splice	c.e4-1	p.R117_splice	PTPN21_uc010twc.1_Splice_Site|PTPN21_uc010atf.1_Splice_Site_p.R117_splice	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TACTGATACCTATAAAAAATG	0.338													0	0	0	1	0	10	6										C	88974366	T	C	88974366	5	2	82	1	0	0	0	0	0	0	1	0	12786	1536	53	5	3239	5	PTPN21	14	88974366	Splice_Site	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	10648882	88974366	18375174	329	24713										
CCDC88C	440193	broad.mit.edu	37	chr14	91806270	91806270	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcgatgagcctccgcaggtgGagcaccatgctcctcgacag	12	14	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:91806270G>A	uc010aty.2	-	7	681	c.582C>T	c.(580-582)CTC>CTT	p.L194L	CCDC88C_uc010twk.1_Silent_p.L158L	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	194					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TCCGCAGGTGGAGCACCATGC	0.662													0	0	0	1	0	6	2										A	91806270	G	A	91806270	2	1	82	1	0	0	0	0	0	0	0	1	2865	1161	41	1		1	CCDC88C	14	91806270	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2831904	91806270	15543270	330	24714										
C14orf49	161176	broad.mit.edu	37	chr14	95912274	95912289	+	Frame_Shift_Del	DEL	CTGTTATGCAGCAGGT	CTGTTATGCAGCAGGT	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcttttcctctgcaggaggCtgttatgcagcaggtctctg					rs28526182	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr14:95912274_95912289delCTGTTATGCAGCAGGT	uc001yei.3	-	8	1604_1619	c.1589_1604delACCTGCTGCATAACAG	c.(1588-1605)GACCTGCTGCATAACAGCfs	p.D530fs	C14orf49_uc010avi.2_Frame_Shift_Del_p.D530fs|C14orf49_uc001yej.1_Frame_Shift_Del_p.D530fs	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	530_535	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTGCAGGAGGCTGTTATGCAGCAGGTCTCTGTCCCT	0.528																		17	33	---	---								-	95912289	CTGTTATGCAGCAGGT	-	95912274	7	5	82	1	0	1	0	1	0	0	0	0	1776	797	28	0	1363	0	C14orf49	14	95912274	Frame_Shift_Del	DEL	CTGTTATGCAGCAGGT	TCGA-FD-A3SN-01A-12D-A22Z-08	4106004	95912274	11437266	331	24715										
EXD1	161829	broad.mit.edu	37	chr15	41482260	41482260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaggggtaacaggtaggtagCttccagggccaaaattttca	12	7	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:41482260C>T	uc001znk.2	-	9	948	c.757G>A	c.(757-759)GCT>ACT	p.A253T	EXD1_uc001znj.2_Missense_Mutation_p.A51T|EXD1_uc010ucv.1_Missense_Mutation_p.A311T	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	253					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						AGGTAGGTAGCTTCCAGGGCC	0.463													0	0	0	1	0	37	12										T	41482260	C	T	41482260	3	4	82	1	0	0	0	0	1	0	0	0	5297	797	28	2	795	2	EXD1	15	41482260	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		41482260	61049132	332	24716										
PLA2G4F	255189	broad.mit.edu	37	chr15	42434263	42434263	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aaggtctccacgttgttcagGacgttgtatcgactgagggc	13	9	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:42434263G>A	uc001zoz.2	-	20	2532	c.2469C>T	c.(2467-2469)GTC>GTT	p.V823V	PLA2G4F_uc010bcq.2_Silent_p.V120V|PLA2G4F_uc001zoy.2_Silent_p.V455V|PLA2G4F_uc010bcr.2_Silent_p.V574V|PLA2G4F_uc001zpa.2_Silent_p.V574V|PLA2G4F_uc010bcs.2_Silent_p.V610V	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	823	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CGTTGTTCAGGACGTTGTATC	0.597													0	0	0	1	0	25	13										A	42434263	G	A	42434263	2	1	82	1	0	0	0	0	0	0	0	1	12006	1161	41	1		1	PLA2G4F	15	42434263	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	952003	42434263	60097129	333	24717										
SPG11	80208	broad.mit.edu	37	chr15	44876484	44876484	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cggcacagccagatctgcttCtccagctcctccagcttatc	7	17	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:44876484C>G	uc001ztx.2	-	30	5425	c.5394G>C	c.(5392-5394)GAG>GAC	p.E1798D	SPG11_uc010bdw.2_Missense_Mutation_p.E87D|SPG11_uc010ueh.1_Missense_Mutation_p.E1798D|SPG11_uc010uei.1_Missense_Mutation_p.E1798D|SPG11_uc001zty.1_Missense_Mutation_p.E527D	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1798	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AGATCTGCTTCTCCAGCTCCT	0.567													0	0	0	1	0	16	18										G	44876484	C	G	44876484	3	3	82	1	0	0	0	0	1	0	0	0	15040	912	32	1	1981	1	SPG11	15	44876484	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2442221	44876484	57654908	334	24718										
SNX22	79856	broad.mit.edu	37	chr15	64445876	64445876	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgagggagttcctgcctggcGacagcaggcaagtcaaagcc	14	11	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:64445876G>A	uc002anc.1	+	5	444	c.385G>A	c.(385-387)GAC>AAC	p.D129N	SNX22_uc002amz.1_Missense_Mutation_p.D101N|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	129					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						CCTGCCTGGCGACAGCAGGCA	0.647											OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	21	16										A	64445876	G	A	64445876	3	1	82	1	0	0	0	0	1	0	0	0	14894	1058	37	1	403	1	SNX22	15	64445876	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	19569392	64445876	38085516	335	24719										
DPP8	54878	broad.mit.edu	37	chr15	65759415	65759415	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aacaaacttaatacctgactGatgcagcaagaatgtgagta	8	7	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:65759415G>A	uc002aov.2	-	13	3309	c.1731C>T	c.(1729-1731)ATC>ATT	p.I577I	DPP8_uc002aow.2_Silent_p.I577I|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Silent_p.I561I|DPP8_uc002aoy.2_Silent_p.I577I|DPP8_uc002aoz.2_Silent_p.I561I|DPP8_uc010bhj.2_Silent_p.I577I|DPP8_uc002apa.2_Silent_p.I474I|DPP8_uc010bhi.2_5'UTR|DPP8_uc010bhk.1_Silent_p.I146I	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	577					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						ATACCTGACTGATGCAGCAAG	0.408													0	0	0	1	0	12	11										A	65759415	G	A	65759415	2	1	82	1	0	0	0	0	0	0	0	1	4732	1280	45	1		1	DPP8	15	65759415	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1313539	65759415	36771977	336	24720										
MYO9A	4649	broad.mit.edu	37	chr15	72186109	72186109	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atttttactgtttaaggcttCtttgctgacactttaaataa	5	6	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:72186109C>T	uc002atl.3	-	26	5526	c.5053G>A	c.(5053-5055)GAA>AAA	p.E1685K	MYO9A_uc002atn.1_Missense_Mutation_p.E1666K|MYO9A_uc002atk.2_Missense_Mutation_p.E409K|MYO9A_uc002atm.1_Missense_Mutation_p.E409K	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1685	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TTTAAGGCTTCTTTGCTGACA	0.378													0	0	0	1	0	11	10										T	72186109	C	T	72186109	3	4	82	1	0	0	0	0	1	0	0	0	10084	922	32	1	2661	1	MYO9A	15	72186109	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	6426694	72186109	30345283	337	24721										
CSK	1445	broad.mit.edu	37	chr15	75091647	75091647	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agatcacacgggagcaggctGagcggcttctgtacccgccg	14	13	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:75091647G>A	uc010bkb.1	+	6	460	c.277G>A	c.(277-279)GAG>AAG	p.E93K	CSK_uc002ays.2_Missense_Mutation_p.E93K|CSK_uc010bkc.1_5'UTR	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	93	SH2.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						GGAGCAGGCTGAGCGGCTTCT	0.632													0	0	0	1	0	11	16										A	75091647	G	A	75091647	3	1	82	1	0	0	0	0	1	0	0	0	3943	1291	45	1	291	1	CSK	15	75091647	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2905538	75091647	27439745	338	24722										
ADAMTS7	11173	broad.mit.edu	37	chr15	79063930	79063930	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccacgggaggcaggcacctgGatccagacaggctccttggt	14	13	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:79063930G>A	uc002bej.3	-	15	2584	c.2373C>T	c.(2371-2373)ATC>ATT	p.I791I	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Silent_p.I791I	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	791	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CAGGCACCTGGATCCAGACAG	0.657													0	0	0	1	0	7	4										A	79063930	G	A	79063930	2	1	82	1	0	0	0	0	0	0	0	1	271	1164	41	1		1	ADAMTS7	15	79063930	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3972283	79063930	23467462	339	24723										
ACAN	176	broad.mit.edu	37	chr15	89386642	89386642	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccttccaggaagcagccaatGagtgccggcggctgggtgcc	15	13	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:89386642G>A	uc010upo.1	+	6	1188	c.814G>A	c.(814-816)GAG>AAG	p.E272K	ACAN_uc002bmx.2_Missense_Mutation_p.E272K|ACAN_uc010upp.1_Missense_Mutation_p.E272K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	272					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			AGCAGCCAATGAGTGCCGGCG	0.642													0	0	0	1	0	12	11										A	89386642	G	A	89386642	3	1	82	1	0	0	0	0	1	0	0	0	117	1291	45	1	832	1	ACAN	15	89386642	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	10322712	89386642	13144750	340	24724										
C15orf42	90381	broad.mit.edu	37	chr15	90119460	90119460	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tctactgggtggataccaccGaatggtctaaggtaaggaag	13	7	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:90119460G>A	uc002boe.2	+	1	643	c.643G>A	c.(643-645)GAA>AAA	p.E215K		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	215					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GGATACCACCGAATGGTCTAA	0.542													0	0	0	1	0	10	11										A	90119460	G	A	90119460	3	1	82	1	0	0	0	0	1	0	0	0	1796	1059	37	1	645	1	C15orf42	15	90119460	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	732818	90119460	12411932	341	24725										
CIB1	10519	broad.mit.edu	37	chr15	90774617	90774617	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cggaaggcataatgggacttGatgtctggcgtggctgtgtc	16	7	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:90774617G>A	uc002bpb.3	-	4	480	c.318C>T	c.(316-318)ATC>ATT	p.I106I	C15orf58_uc002bpc.2_5'Flank	NM_006384	NP_006375	Q99828	CIB1_HUMAN	calcium and integrin binding 1	106	EF-hand 1.				apoptosis|cell adhesion|double-strand break repair	apical plasma membrane|endoplasmic reticulum|filopodium|nucleoplasm	calcium ion binding|protein binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0141)|all_lung(78;0.0303)		BRCA - Breast invasive adenocarcinoma(143;0.00269)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			AATGGGACTTGATGTCTGGCG	0.572													0	0	0	1	0	14	12										A	90774617	G	A	90774617	2	1	82	1	0	0	0	0	0	0	0	1	3420	1280	45	1		1	CIB1	15	90774617	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	655157	90774617	11756775	342	24726										
LINS1	55180	broad.mit.edu	37	chr15	101109805	101109805	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taaacactgctctgtggattCcacgtcagaatcgtcagagc	9	11	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr15:101109805C>G	uc002bwe.2	-	8	2203	c.1912G>C	c.(1912-1914)GAA>CAA	p.E638Q	LINS1_uc002bwd.2_Missense_Mutation_p.E225Q|LINS1_uc002bwf.2_Missense_Mutation_p.E638Q|LINS1_uc002bwg.2_Missense_Mutation_p.E638Q|LINS1_uc002bwh.2_Missense_Mutation_p.E638Q	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	638											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TCTGTGGATTCCACGTCAGAA	0.493													0	0	0	1	0	40	24										G	101109805	C	G	101109805	3	3	82	1	0	0	0	0	1	0	0	0	8818	864	30	1	365	1	LINS1	15	101109805	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	10335188	101109805	1421587	343	24727										
SRRM2	23524	broad.mit.edu	37	chr16	2812478	2812478	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagtggcaggtcacgctctaGaaccccagctagacgtggcc	12	13	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:2812478G>A	uc002crk.2	+	11	2498	c.1949G>A	c.(1948-1950)AGA>AAA	p.R650K	SRRM2_uc002crj.1_Missense_Mutation_p.R554K|SRRM2_uc002crl.1_Missense_Mutation_p.R650K|SRRM2_uc010bsu.1_Missense_Mutation_p.R554K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	650	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCACGCTCTAGAACCCCAGCT	0.612													0	0	0	1	0	34	51										A	2812478	G	A	2812478	3	1	82	1	0	0	0	0	1	0	0	0	15168	942	33	1	1987	1	SRRM2	16	2812478	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		2812478	87542275	344	24728										
ZNF263	10127	broad.mit.edu	37	chr16	3340089	3340089	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgagtgtgggaaaagtttctCtcggagttcacacctcgtca	11	10	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:3340089C>T	uc002cuq.2	+	6	1915	c.1583C>T	c.(1582-1584)TCT>TTT	p.S528F	ZNF263_uc010uww.1_Missense_Mutation_p.S176F|ZNF263_uc002cur.2_Missense_Mutation_p.S176F	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	528	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						AAAAGTTTCTCTCGGAGTTCA	0.507													0	0	0	1	0	10	34										T	3340089	C	T	3340089	3	4	82	1	0	0	0	0	1	0	0	0	17800	913	32	1	1605	1	ZNF263	16	3340089	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	527611	3340089	87014664	345	24729										
ERCC4	2072	broad.mit.edu	37	chr16	14042169	14042169	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atttcattcacacctcttttGcagaagtcgtatcaaaagga	6	9	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:14042169G>C	uc002dce.2	+	11	2725	c.2716G>C	c.(2716-2718)GCA>CCA	p.A906P	ERCC4_uc010uyz.1_Missense_Mutation_p.A456P	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	906	Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						CACCTCTTTTGCAGAAGTCGT	0.448			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	35	58										C	14042169	G	C	14042169	3	2	82	1	0	0	0	0	1	0	0	0	5215	1319	46	4	2758	4	ERCC4	16	14042169	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	10702080	14042169	76312584	346	24730										
BFAR	51283	broad.mit.edu	37	chr16	14738279	14738279	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctctcaaaagcaccggccctCagatttctgttagtgaattt	7	11	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:14738279C>T	uc002dco.2	+	2	357	c.76C>T	c.(76-78)CAG>TAG	p.Q26*	BFAR_uc002dcm.2_Nonsense_Mutation_p.Q26*|BFAR_uc002dcn.2_Nonsense_Mutation_p.Q26*|BFAR_uc002dcp.2_Nonsense_Mutation_p.Q26*|BFAR_uc010uzh.1_5'UTR	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	26	Cytoplasmic (Potential).				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						CACCGGCCCTCAGATTTCTGT	0.493													0	0	0	1	0	40	63										T	14738279	C	T	14738279	4	4	82	1	0	0	0	0	0	1	0	0	1414	827	29	1	78	1	BFAR	16	14738279	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	696110	14738279	75616474	347	24731										
C16orf62	57020	broad.mit.edu	37	chr16	19619564	19619564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcctaaattggtttttcaaGattgcctccatcagggaact	8	9	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:19619564G>C	uc002dgn.1	+	10	861	c.849G>C	c.(847-849)AAG>AAC	p.K283N	C16orf62_uc002dgo.1_Missense_Mutation_p.K283N|C16orf62_uc002dgp.1_Missense_Mutation_p.K32N|C16orf62_uc010vas.1_Missense_Mutation_p.K157N|C16orf62_uc002dgm.1_Missense_Mutation_p.K283N	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	283						integral to membrane				ovary(1)	1						GGTTTTTCAAGATTGCCTCCA	0.353													0	0	0	1	0	23	52										C	19619564	G	C	19619564	3	2	82	1	0	0	0	0	1	0	0	0	1825	933	33	1	887	1	C16orf62	16	19619564	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4881285	19619564	70735189	348	24732										
LOC81691	81691	broad.mit.edu	37	chr16	20837242	20837242	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggatgaactggtcaaacctGaaaacaagattctggactac	9	8	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:20837242G>A	uc002dhv.2	+	8	1056	c.793G>A	c.(793-795)GAA>AAA	p.E265K	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Missense_Mutation_p.E265K|LOC81691_uc002dhw.2_Missense_Mutation_p.E8K|LOC81691_uc002dhy.3_Missense_Mutation_p.E265K	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	265	Exonuclease.					nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						GGTCAAACCTGAAAACAAGAT	0.473													0	0	0	1	0	5	13										A	20837242	G	A	20837242	3	1	82	1	0	0	0	0	1	0	0	0	8890	1291	45	1	819	1	LOC81691	16	20837242	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1217678	20837242	69517511	349	24733										
CRYM	1428	broad.mit.edu	37	chr16	21272618	21272618	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttctcacagtgggctggtttCactcccttaatcacttctcc	6	14	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:21272618C>T	uc002dik.2	-	7	922	c.837G>A	c.(835-837)GTG>GTA	p.V279V	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Silent_p.V237V|CRYM_uc002dim.2_Silent_p.V279V	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	279					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	GGGCTGGTTTCACTCCCTTAA	0.517													0	0	0	1	0	14	26										T	21272618	C	T	21272618	2	4	82	1	0	0	0	0	0	0	0	1	3921	813	29	1		1	CRYM	16	21272618	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	435376	21272618	69082135	350	24734										
OTOA	146183	broad.mit.edu	37	chr16	21721355	21721355	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cacggagccatctccaccctCaaccaggtctcaggttgggc	10	16	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:21721355C>T	uc002djh.2	+	12	1252	c.1251C>T	c.(1249-1251)CTC>CTT	p.L417L	uc002diq.3_Intron|OTOA_uc010vbj.1_Silent_p.L338L|OTOA_uc002dji.2_Silent_p.L93L|OTOA_uc010vbk.1_Silent_p.L65L	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	431					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		TCTCCACCCTCAACCAGGTCT	0.517													0	0	0	1	0	13	23										T	21721355	C	T	21721355	2	4	82	1	0	0	0	0	0	0	0	1	11302	813	29	1		1	OTOA	16	21721355	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	448737	21721355	68633398	351	24735										
HS3ST2	9956	broad.mit.edu	37	chr16	22826363	22826363	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccggacgtgcgggccttgggCacggaaccccacttctttga	13	14	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:22826363C>T	uc002dli.2	+	1	504	c.432C>T	c.(430-432)GGC>GGT	p.G144G	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	144	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		GGGCCTTGGGCACGGAACCCC	0.647													0	0	0	1	0	10	16										T	22826363	C	T	22826363	2	4	82	1	0	0	0	0	0	0	0	1	7364	697	25	2		2	HS3ST2	16	22826363	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1105008	22826363	67528390	352	24736										
COG7	91949	broad.mit.edu	37	chr16	23400346	23400346	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctggtcttcagtagcgtcacGatgtgctggagggtgcggga	17	8	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:23400346G>A	uc002dlo.2	-	17	2396	c.2208C>T	c.(2206-2208)ATC>ATT	p.I736I		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	736					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		GTAGCGTCACGATGTGCTGGA	0.617													0	0	0	1	0	16	17										A	23400346	G	A	23400346	2	1	82	1	0	0	0	0	0	0	0	1	3663	1048	37	1		1	COG7	16	23400346	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	573983	23400346	66954407	353	24737										
KIAA0556	23247	broad.mit.edu	37	chr16	27751476	27751476	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgaccacagcatcctggttGaccagaagaacgagaagagc	11	11	0	6			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:27751476G>A	uc002dow.2	+	15	1882	c.1858G>A	c.(1858-1860)GAC>AAC	p.D620N		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	620	Potential.									ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						CATCCTGGTTGACCAGAAGAA	0.527													0	0	0	1	0	27	66										A	27751476	G	A	27751476	3	1	82	1	0	0	0	0	1	0	0	0	8183	1290	45	1	1916	1	KIAA0556	16	27751476	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4351130	27751476	62603277	354	24738										
TUFM	7284	broad.mit.edu	37	chr16	28857543	28857543	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctccctgaccactcaccgctGaagtggggcgtcgcgcgcag	13	16	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:28857543G>A	uc002drh.2	-	1	187	c.48C>T	c.(46-48)TTC>TTT	p.F16F	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	13						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						ACTCACCGCTGAAGTGGGGCG	0.687													0	0	0	1	0	3	6										A	28857543	G	A	28857543	2	1	82	1	0	0	0	0	0	0	0	1	16768	1281	45	1		1	TUFM	16	28857543	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1106067	28857543	61497210	355	24739										
INO80E	283899	broad.mit.edu	37	chr16	30012320	30012320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcctccttcaacagggtttCcccttcaggcctccggggtc	10	16	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:30012320C>T	uc002dvg.1	+	5	456	c.355C>T	c.(355-357)CCC>TCC	p.P119S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvh.1_RNA|INO80E_uc002dvi.1_Missense_Mutation_p.P119S|INO80E_uc002dvj.1_RNA|INO80E_uc002dvk.1_Missense_Mutation_p.P119S	NM_173618	NP_775889	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	119	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				skin(1)	1						AACAGGGTTTCCCCTTCAGGC	0.637													0	0	0	1	0	10	21										T	30012320	C	T	30012320	3	4	82	1	0	0	0	0	1	0	0	0	7750	855	30	1	373	1	INO80E	16	30012320	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1154777	30012320	60342433	356	24740										
DCTPP1	79077	broad.mit.edu	37	chr16	30440456	30440456	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gatggaactgttcccagtctCgttccgcagcaaactcagca	9	13	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:30440456C>T	uc002dyf.2	-	2	206	c.134G>A	c.(133-135)CGA>CAA	p.R45Q	ZNF771_uc010bzx.2_RNA	NM_024096	NP_077001	Q9H773	DCTP1_HUMAN	dCTP pyrophosphatase 1	45	EAR.				nucleoside triphosphate catabolic process	cytosol	dCTP diphosphatase activity|identical protein binding|magnesium ion binding				0						TTCCCAGTCTCGTTCCGCAGC	0.483													0	0	0	1	0	21	53										T	30440456	C	T	30440456	3	4	82	1	0	0	0	0	1	0	0	0	4312	884	31	1	386	1	DCTPP1	16	30440456	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	428136	30440456	59914297	357	24741										
ADCY7	113	broad.mit.edu	37	chr16	50335123	50335123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctacctggtcatcgaccccCgggtacgagggctcagaggc	13	15	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:50335123C>T	uc002egd.1	+	9	1634	c.1366C>T	c.(1366-1368)CGG>TGG	p.R456W	ADCY7_uc002egb.1_Missense_Mutation_p.R456W|ADCY7_uc002egc.1_Missense_Mutation_p.R456W	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	456	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CATCGACCCCCGGGTACGAGG	0.682													0	0	0	1	0	4	5										T	50335123	C	T	50335123	3	4	82	1	0	0	0	0	1	0	0	0	299	643	23	2	1400	2	ADCY7	16	50335123	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	19894667	50335123	40019630	358	24742										
CHD9	80205	broad.mit.edu	37	chr16	53301296	53301296	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggctgaattatctgaagctGaaagtgaaggagatgaaaag	13	3	1	6			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:53301296G>A	uc002ehb.2	+	20	4575	c.4411G>A	c.(4411-4413)GAA>AAA	p.E1471K	CHD9_uc002egy.2_Missense_Mutation_p.E1471K|CHD9_uc002ehc.2_Missense_Mutation_p.E1471K|CHD9_uc002ehf.2_Missense_Mutation_p.E585K|CHD9_uc010cbw.2_5'UTR|CHD9_uc002ehd.2_Missense_Mutation_p.E997K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1471					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ATCTGAAGCTGAAAGTGAAGG	0.413													0	0	0	1	0	27	34										A	53301296	G	A	53301296	3	1	82	1	0	0	0	0	1	0	0	0	3332	1291	45	1	4489	1	CHD9	16	53301296	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2966173	53301296	37053457	359	24743										
CNOT1	23019	broad.mit.edu	37	chr16	58621779	58621779	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acactcctgaatcagaaactGagtctttaaaaataaaaaat	4	7	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:58621779G>A	uc002env.2	-	4	507	c.214C>T	c.(214-216)CAG>TAG	p.Q72*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.Q72*|CNOT1_uc002enx.2_Nonsense_Mutation_p.Q72*|CNOT1_uc002enz.1_5'UTR	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	72					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATCAGAAACTGAGTCTTTAAA	0.353													0	0	0	1	0	20	35										A	58621779	G	A	58621779	4	1	82	1	0	0	0	0	0	1	0	0	3617	1299	45	1	7322	1	CNOT1	16	58621779	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	5320483	58621779	31732974	360	24744										
SLC9A5	6553	broad.mit.edu	37	chr16	67291253	67291253	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctgcctgtccatagggcttGaccatcaagccactggtcaa	9	14	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:67291253G>C	uc002esm.2	+	8	1404	c.1341G>C	c.(1339-1341)TTG>TTC	p.L447F	SLC9A5_uc010cee.2_Missense_Mutation_p.L152F|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	447	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CATAGGGCTTGACCATCAAGC	0.542													0	0	0	1	0	16	54										C	67291253	G	C	67291253	3	2	82	1	0	0	0	0	1	0	0	0	14717	1281	45	1	1371	1	SLC9A5	16	67291253	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	8669474	67291253	23063500	361	24745										
ACD	65057	broad.mit.edu	37	chr16	67694244	67694244	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cggaggaggaggccccgcccAcgtacaccccgcgcctgcgc	14	19	0	0	rs2303761		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:67694244A>G	uc002etq.3	-	1	475	c.138T>C	c.(136-138)CGT>CGC	p.R46R	ACD_uc002etp.3_Silent_p.R46R|ACD_uc002etr.3_Silent_p.R46R|ACD_uc010vjt.1_Silent_p.R36R|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	46					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GGCCCCGCCCACGTACACCCC	0.736													0	0	0	1	0	6	12										G	67694244	A	G	67694244	2	3	82	1	0	0	0	0	0	0	0	1	135	146	6	5		5	ACD	16	67694244	Silent	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	402991	67694244	22660509	362	24746										
C16orf86	388284	broad.mit.edu	37	chr16	67702120	67702120	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	caggaaaggcccagcgcctgCggccgctgtaccagtacgtc	13	15	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:67702120C>T	uc002ety.2	+	4	728	c.571C>T	c.(571-573)CGG>TGG	p.R191W	C16orf48_uc002etw.1_5'Flank|C16orf48_uc010cem.1_5'Flank|C16orf86_uc002etx.1_3'UTR|C16orf86_uc002etz.2_RNA	NM_001012984	NP_001013002	Q6ZW13	CP086_HUMAN	hypothetical protein LOC388284	191											0		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCAGCGCCTGCGGCCGCTGTA	0.657											OREG0023886	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	9	10										T	67702120	C	T	67702120	3	4	82	1	0	0	0	0	1	0	0	0	1839	759	27	2	585	2	C16orf86	16	67702120	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7876	67702120	22652633	363	24747										
TERF2	7014	broad.mit.edu	37	chr16	69419340	69419340	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gacagacactgcataacccgCagcaatcgggacacggtgtg	12	12	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:69419340C>T	uc002exd.2	-	2	428	c.303G>A	c.(301-303)CTG>CTA	p.L101L	TERF2_uc002exe.2_Silent_p.L101L	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	101	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				GCATAACCCGCAGCAATCGGG	0.532													0	0	0	1	0	20	42										T	69419340	C	T	69419340	2	4	82	1	0	0	0	0	0	0	0	1	15759	697	25	2		2	TERF2	16	69419340	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1717220	69419340	20935413	364	24748										
CYB5B	80777	broad.mit.edu	37	chr16	69458758	69458758	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atgtcacccgcttcctcaacGaggtggggcctgggaggtgg	16	11	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:69458758G>A	uc002exg.1	+	1	261	c.172G>A	c.(172-174)GAG>AAG	p.E58K	CYB5B_uc002exf.2_Missense_Mutation_p.E58K|CYB5B_uc010cfl.1_Missense_Mutation_p.E58K	NM_030579	NP_085056	O43169	CYB5B_HUMAN	cytochrome b5 outer mitochondrial membrane	54	Cytochrome b5 heme-binding.				electron transport chain|transport	integral to membrane|mitochondrial outer membrane	heme binding				0		Ovarian(137;0.101)				CTTCCTCAACGAGGTGGGGCC	0.602													0	0	0	1	0	15	29										A	69458758	G	A	69458758	3	1	82	1	0	0	0	0	1	0	0	0	4123	1059	37	1	174	1	CYB5B	16	69458758	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	39418	69458758	20895995	365	24749										
NFAT5	10725	broad.mit.edu	37	chr16	69687308	69687308	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gctcagtgaaagatagaacaCagcaaggctttcctacagta	9	9	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:69687308C>T	uc002exm.1	+	4	2136	c.928C>T	c.(928-930)CAG>TAG	p.Q310*	NFAT5_uc002exh.1_Nonsense_Mutation_p.Q104*|NFAT5_uc002exi.2_Nonsense_Mutation_p.Q234*|NFAT5_uc002exj.1_Nonsense_Mutation_p.Q234*|NFAT5_uc002exk.1_Nonsense_Mutation_p.Q234*|NFAT5_uc002exl.1_Nonsense_Mutation_p.Q328*|NFAT5_uc002exn.1_Nonsense_Mutation_p.Q328*	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	310	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AGATAGAACACAGCAAGGCTT	0.398													0	0	0	1	0	14	37										T	69687308	C	T	69687308	4	4	82	1	0	0	0	0	0	1	0	0	10360	479	17	2	1000	2	NFAT5	16	69687308	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	228550	69687308	20667445	366	24750										
KIAA0174	9798	broad.mit.edu	37	chr16	71961660	71961660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccagcacctcagcatctgaaGacattgactttgatgatctt	7	11	3	5			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:71961660G>C	uc002fbj.1	+	12	1367	c.1084G>C	c.(1084-1086)GAC>CAC	p.D362H	KIAA0174_uc010cgh.1_Missense_Mutation_p.D362H|KIAA0174_uc002fbk.1_Missense_Mutation_p.K347N|KIAA0174_uc002fbm.1_Missense_Mutation_p.D349H|KIAA0174_uc002fbl.1_Missense_Mutation_p.D318H|KIAA0174_uc002fbn.1_Missense_Mutation_p.D201H|KIAA0174_uc010cgi.1_Missense_Mutation_p.D120H|KIAA0174_uc010cgj.1_Missense_Mutation_p.D266H|KIAA0174_uc010vml.1_RNA			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	347	Interaction with VTA1.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						AGCATCTGAAGACATTGACTT	0.458													0	0	0	1	0	67	125										C	71961660	G	C	71961660	3	2	82	1	0	0	0	0	1	0	0	0	8158	933	33	1	1075	1	KIAA0174	16	71961660	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2274352	71961660	18393093	367	24751										
RFWD3	55159	broad.mit.edu	37	chr16	74685896	74685896	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agagctgtcactgtcagaatCagaactactagacacctgca	8	11	3	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:74685896C>T	uc002fda.2	-	3	741	c.643G>A	c.(643-645)GAT>AAT	p.D215N	RFWD3_uc010cgq.2_Missense_Mutation_p.D215N	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	215					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTGTCAGAATCAGAACTACTA	0.478													0	0	0	1	0	34	61										T	74685896	C	T	74685896	3	4	82	1	0	0	0	0	1	0	0	0	13261	826	29	1	1725	1	RFWD3	16	74685896	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2724236	74685896	15668857	368	24752										
CMIP	80790	broad.mit.edu	37	chr16	81739167	81739167	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgctccaggtgctgaacctgTgcgagaccccggtcacagac	12	14	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:81739167T>C	uc002fgp.2	+	19	2227	c.2155T>C	c.(2155-2157)TGC>CGC	p.C719R	CMIP_uc002fgq.1_Missense_Mutation_p.C625R|CMIP_uc010vnq.1_Missense_Mutation_p.C532R|CMIP_uc002fgr.1_Missense_Mutation_p.C566R	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	685	LRR 3.					cytoplasm|nucleus					0						GCTGAACCTGTGCGAGACCCC	0.637													0	0	0	1	0	6	9										C	81739167	T	C	81739167	3	2	82	1	0	0	0	0	1	0	0	0	3578	1696	59	5	2251	5	CMIP	16	81739167	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	7053271	81739167	8615586	369	24753										
CDH15	1013	broad.mit.edu	37	chr16	89261279	89261279	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cctctttatagggcttggagGctgcagatagtgaccccagt	12	10	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr16:89261279G>A	uc002fmt.2	+	14	2238	c.2161G>A	c.(2161-2163)GCT>ACT	p.A721T		NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	721	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGGCTTGGAGGCTGCAGATAG	0.637													0	0	0	1	0	3	8										A	89261279	G	A	89261279	3	1	82	1	0	0	0	0	1	0	0	0	3100	1203	42	2	2215	2	CDH15	16	89261279	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7522112	89261279	1093474	370	24754										
KIAA0664	23277	broad.mit.edu	37	chr17	2604800	2604800	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccgctcatggtgagtactttCaggcactgcaagggcttcgg	13	11	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:2604800C>T	uc002fuy.1	-	6	731	c.645G>A	c.(643-645)CTG>CTA	p.L215L	KIAA0664_uc002fux.1_Silent_p.L147L	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	215							binding			breast(2)	2						TGAGTACTTTCAGGCACTGCA	0.662													0	0	0	1	0	10	7										T	2604800	C	T	2604800	2	4	82	1	0	0	0	0	0	0	0	1	8189	813	29	1		1	KIAA0664	17	2604800	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		2604800	78590410	371	24755										
INCA1	388324	broad.mit.edu	37	chr17	4892128	4892128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcctgtggataggttgctctCtcctcttccagatcagggta	10	11	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:4892128C>G	uc002gaj.2	-	7	959	c.507G>C	c.(505-507)GAG>GAC	p.E169D	CAMTA2_uc010cku.1_5'Flank|CAMTA2_uc002gag.1_5'Flank|CAMTA2_uc002gah.1_5'Flank|CAMTA2_uc002gai.1_5'Flank|CAMTA2_uc010vsu.1_5'Flank|INCA1_uc002gak.2_Missense_Mutation_p.E169D|INCA1_uc002gal.2_Missense_Mutation_p.E154D|INCA1_uc002gam.2_Missense_Mutation_p.E154D	NM_213726	NP_998891	Q0VD86	INCA1_HUMAN	inhibitor of CDK, cyclin A1 interacting protein	169						nucleus					0						AGGTTGCTCTCTCCTCTTCCA	0.582													0	0	0	1	0	19	10										G	4892128	C	G	4892128	3	3	82	1	0	0	0	0	1	0	0	0	7732	912	32	1	211	1	INCA1	17	4892128	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2287328	4892128	76303082	372	24756										
DHX33	56919	broad.mit.edu	37	chr17	5372147	5372147	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccagagcctggccggaatctCttggccggcgggaagcccgc	15	15	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:5372147C>T	uc002gca.2	-	1	35	c.33G>A	c.(31-33)AAG>AAA	p.K11K	DHX33_uc002gcb.2_5'UTR|DHX33_uc010clf.2_Silent_p.K11K	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	11						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						GCCGGAATCTCTTGGCCGGCG	0.721													0	0	0	1	0	2	0										T	5372147	C	T	5372147	2	4	82	1	0	0	0	0	0	0	0	1	4506	912	32	1		1	DHX33	17	5372147	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	480019	5372147	75823063	373	24757										
NLRP1	22861	broad.mit.edu	37	chr17	5440230	5440230	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agggccctcagttcctgcctCatctcatcactcagagttgt	8	14	5	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:5440230C>A	uc002gci.2	-	8	3456	c.2901G>T	c.(2899-2901)ATG>ATT	p.M967I	NLRP1_uc002gcg.1_Missense_Mutation_p.M967I|NLRP1_uc002gck.2_Missense_Mutation_p.M967I|NLRP1_uc002gcj.2_Intron|NLRP1_uc002gcl.2_Intron|NLRP1_uc002gch.3_Missense_Mutation_p.M967I|NLRP1_uc010clh.2_Missense_Mutation_p.M967I	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	967	LRR 6.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GTTCCTGCCTCATCTCATCAC	0.622													1	0	5.50884e-06	1	5.59432e-06	12	12										A	5440230	C	A	5440230	3	1	82	1	0	0	0	0	1	0	0	0	10471	826	29	3	1635	3	NLRP1	17	5440230	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	68083	5440230	75754980	374	24758										
USP43	124739	broad.mit.edu	37	chr17	9580108	9580108	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccctctaagagccagcggttCctgcgggttggcctggccgt	14	14	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:9580108C>T	uc010cod.2	+	5	879	c.879C>T	c.(877-879)TTC>TTT	p.F293F	USP43_uc002gma.3_5'UTR|USP43_uc010vva.1_Silent_p.F293F|USP43_uc010coe.2_Silent_p.F90F	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	293					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCAGCGGTTCCTGCGGGTTG	0.557													0	0	0	1	0	8	4										T	9580108	C	T	9580108	2	4	82	1	0	0	0	0	0	0	0	1	17071	854	30	1		1	USP43	17	9580108	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	4139878	9580108	71615102	375	24759										
RICH2	9912	broad.mit.edu	37	chr17	12860053	12860053	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atccagcatgcagactggttCttccctgggggtaggtgaca	13	10	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:12860053C>T	uc002gnr.3	+	15	1659	c.1332C>T	c.(1330-1332)TTC>TTT	p.F444F	RICH2_uc010vvk.1_Silent_p.F444F|RICH2_uc010vvl.1_Silent_p.F444F|RICH2_uc002gns.3_Silent_p.F244F|RICH2_uc010vvm.1_Silent_p.F444F|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_Silent_p.F167F	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	444	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						CAGACTGGTTCTTCCCTGGGG	0.522													0	0	0	1	0	8	12										T	12860053	C	T	12860053	2	4	82	1	0	0	0	0	0	0	0	1	13357	912	32	1		1	RICH2	17	12860053	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3279945	12860053	68335157	376	24760										
FAM83G	644815	broad.mit.edu	37	chr17	18874745	18874745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aggcccactggctaccgcccGtcctggcctttaggtgcttc	11	16	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:18874745G>A	uc002guw.2	-	6	2566	c.2399C>T	c.(2398-2400)ACG>ATG	p.T800M	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	800								p.T800T(1)		ovary(1)|central_nervous_system(1)	2						GCTACCGCCCGTCCTGGCCTT	0.637													0	0	0	1	0	42	34										A	18874745	G	A	18874745	3	1	82	1	0	0	0	0	1	0	0	0	5639	1145	40	2	76	2	FAM83G	17	18874745	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6014692	18874745	62320465	377	24761										
NF1	4763	broad.mit.edu	37	chr17	29556856	29556866	+	Frame_Shift_Del	DEL	TTATTGACTGA	TTATTGACTGA	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atttgttctttctttaggttTtattgactgataccaatact							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			TTATTGACTGA	-	TTATTGACTGA	TTATTGACTGA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:29556856_29556866delTTATTGACTGA	uc002hgg.2	+	22	3187_3197	c.2854_2864delTTATTGACTGA	c.(2854-2865)TTATTGACTGATfs	p.L952fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L952fs|NF1_uc010csn.1_Frame_Shift_Del_p.L812fs|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	952_955					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCTTTAGGTTTTATTGACTGATACCAATACT	0.37			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)								23	49	---	---								-	29556866	TTATTGACTGA	-	29556856	7	5	82	1	0	1	0	1	0	0	0	0	10356	1838	64	0	3001	0	NF1	17	29556856	Frame_Shift_Del	DEL	TTATTGACTGA	TCGA-FD-A3SN-01A-12D-A22Z-08	10682111	29556856	51638354	378	24762										
STAC2	342667	broad.mit.edu	37	chr17	37381683	37381683	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taccttggtttcctggagggCggagacggtccctggggggc	18	10	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:37381683C>T	uc002hrs.2	-	1	292	c.73G>A	c.(73-75)GCC>ACC	p.A25T	STAC2_uc010cvt.2_5'UTR	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	25					intracellular signal transduction		metal ion binding			pancreas(1)	1						TCCTGGAGGGCGGAGACGGTC	0.602													0	0	0	1	0	11	10										T	37381683	C	T	37381683	3	4	82	1	0	0	0	0	1	0	0	0	15239	768	27	2	1206	2	STAC2	17	37381683	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	7824827	37381683	43813527	379	24763										
CDK12	51755	broad.mit.edu	37	chr17	37619354	37619354	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgagcaagcggtctctgagtCggagtccactccccaggtga	13	12	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:37619354C>T	uc010cvv.2	+	1	1616	c.1030C>T	c.(1030-1032)CGG>TGG	p.R344W	CDK12_uc010wef.1_Missense_Mutation_p.R344W|CDK12_uc002hrw.3_Missense_Mutation_p.R344W	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	344					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GTCTCTGAGTCGGAGTCCACT	0.552										TCGA Ovarian(9;0.13)			0	0	0	1	0	18	15										T	37619354	C	T	37619354	3	4	82	1	0	0	0	0	1	0	0	0	3128	875	31	1	1032	1	CDK12	17	37619354	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	237671	37619354	43575856	380	24764										
ERBB2	2064	broad.mit.edu	37	chr17	37864656	37864656	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcagaggctgcggattgtgcGaggcacccagctctttgagg	16	10	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:37864656G>A	uc002hso.2	+	3	546	c.308G>A	c.(307-309)CGA>CAA	p.R103Q	ERBB2_uc002hsm.2_Missense_Mutation_p.R73Q|ERBB2_uc010cwa.2_Missense_Mutation_p.R88Q|ERBB2_uc002hsp.2_5'UTR|ERBB2_uc010cwb.2_Missense_Mutation_p.R103Q|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Missense_Mutation_p.R73Q|ERBB2_uc002hsn.1_Missense_Mutation_p.R103Q	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	103	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CGGATTGTGCGAGGCACCCAG	0.612		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	1	0	28	27										A	37864656	G	A	37864656	3	1	82	1	0	0	0	0	1	0	0	0	5206	1058	37	1	318	1	ERBB2	17	37864656	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	245302	37864656	43330554	381	24765										
PTRF	284119	broad.mit.edu	37	chr17	40557078	40557078	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcgcttctccagggtgtgcCgcgtcttctccaggttttcc	11	14	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:40557078C>T	uc002hzo.2	-	2	959	c.800G>A	c.(799-801)CGG>CAG	p.R267Q	PTRF_uc010wgi.1_Missense_Mutation_p.R249Q	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	267	Potential.				regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CAGGGTGTGCCGCGTCTTCTC	0.607													0	0	0	1	0	21	12										T	40557078	C	T	40557078	3	4	82	1	0	0	0	0	1	0	0	0	12815	652	23	2	376	2	PTRF	17	40557078	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	2692422	40557078	40638132	382	24766										
HOXB1	3211	broad.mit.edu	37	chr17	46607197	46607197	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cttgtggtgaagttggtgcgGaggccactgggcgagcccag	18	9	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:46607197G>A	uc002ink.1	-	2	624	c.618C>T	c.(616-618)CTC>CTT	p.L206L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	206	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGTTGGTGCGGAGGCCACTGG	0.607													0	0	0	1	0	48	33										A	46607197	G	A	46607197	2	1	82	1	0	0	0	0	0	0	0	1	7299	1161	41	1		1	HOXB1	17	46607197	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6050119	46607197	34588013	383	24767										
SCPEP1	59342	broad.mit.edu	37	chr17	55083551	55083551	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taggttccttctgaccaaggGgacatggctctgaagatgat	12	8	2	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:55083551G>A	uc002iuv.3	+	13	1367	c.1314G>A	c.(1312-1314)GGG>GGA	p.G438G	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Silent_p.G388G	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	438					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					CTGACCAAGGGGACATGGCTC	0.522													0	0	0	1	0	25	56										A	55083551	G	A	55083551	2	1	82	1	0	0	0	0	0	0	0	1	13935	1219	43	2		2	SCPEP1	17	55083551	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	8476354	55083551	26111659	384	24768										
BZRAP1	9256	broad.mit.edu	37	chr17	56386419	56386419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gggagccccctcctctcctcCggctgcttccaccaactaat	7	19	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:56386419C>T	uc002ivx.3	-	22	5085	c.4214G>A	c.(4213-4215)CGG>CAG	p.R1405Q	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.R1345Q|BZRAP1_uc010wnt.1_Missense_Mutation_p.R1405Q	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1405						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCTCTCCTCCGGCTGCTTCC	0.642													0	0	0	1	0	47	58										T	56386419	C	T	56386419	3	4	82	1	0	0	0	0	1	0	0	0	1577	652	23	2	1399	2	BZRAP1	17	56386419	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1302868	56386419	24808791	385	24769										
RAD51C	5889	broad.mit.edu	37	chr17	56774148	56774148	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagagggaagttttatggttGatagagtggtagaccttgct	14	4	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:56774148G>A	uc002iwu.2	+	3	541	c.499G>A	c.(499-501)GAT>AAT	p.D167N	RAD51C_uc010woa.1_Missense_Mutation_p.D167N|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	167					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTTATGGTTGATAGAGTGGT	0.413								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	1	0	29	47										A	56774148	G	A	56774148	3	1	82	1	0	0	0	0	1	0	0	0	12988	1290	45	1	513	1	RAD51C	17	56774148	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	387729	56774148	24421062	386	24770										
GNA13	10672	broad.mit.edu	37	chr17	63010911	63010911	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gatgcctttggtgggtcttcTggcaagcagaatatcttgtt	12	7	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:63010911T>C	uc002jfc.2	-	4	807	c.598A>G	c.(598-600)AGA>GGA	p.R200G	GNA13_uc010wqh.1_Missense_Mutation_p.R105G	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	200	GTP (By similarity).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						GTGGGTCTTCTGGCAAGCAGA	0.353													0	0	0	1	0	26	43										C	63010911	T	C	63010911	3	2	82	1	0	0	0	0	1	0	0	0	6501	1588	55	5	539	5	GNA13	17	63010911	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	6236763	63010911	18184299	387	24771										
BPTF	2186	broad.mit.edu	37	chr17	65908474	65908474	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgcatttgctgagttcttcaGatgctgaaggtaactaccga	10	9	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:65908474G>A	uc002jgf.2	+	11	4535	c.4474G>A	c.(4474-4476)GAT>AAT	p.D1492N	BPTF_uc002jge.2_Missense_Mutation_p.D1618N	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1618					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GAGTTCTTCAGATGCTGAAGG	0.433													0	0	0	1	0	33	61										A	65908474	G	A	65908474	3	1	82	1	0	0	0	0	1	0	0	0	1495	942	33	1	4902	1	BPTF	17	65908474	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2897563	65908474	15286736	388	24772										
GRIN2C	2905	broad.mit.edu	37	chr17	72846043	72846043	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcattgatggtgagggagccGatggccatgtctgcccgctt	14	10	2	2	rs147077649	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:72846043G>A	uc002jlt.1	-	7	1677	c.1521C>T	c.(1519-1521)ATC>ATT	p.I507I	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.I507I	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	507	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGAGGGAGCCGATGGCCATGT	0.607													0	0	0	1	0	30	50										A	72846043	G	A	72846043	2	1	82	1	0	0	0	0	0	0	0	1	6781	1048	37	1		1	GRIN2C	17	72846043	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	6937569	72846043	8349167	389	24773										
ICT1	3396	broad.mit.edu	37	chr17	73016475	73016475	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atcgcggagcccgtgcggcaGaagatagccatcacggtaac	13	12	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:73016475G>A	uc002jmm.2	+	4	353	c.351G>A	c.(349-351)CAG>CAA	p.Q117Q		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	117					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					CCGTGCGGCAGAAGATAGCCA	0.507													0	0	0	1	0	20	29										A	73016475	G	A	73016475	2	1	82	1	0	0	0	0	0	0	0	1	7488	933	33	1		1	ICT1	17	73016475	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	170432	73016475	8178735	390	24774										
GALK1	2584	broad.mit.edu	37	chr17	73754661	73754661	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcccgccggaagccctctttGctcaccaggtccctggcagc	11	18	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:73754661G>C	uc010wsi.1	-	6	876	c.813C>G	c.(811-813)AGC>AGG	p.S271R	GALK1_uc002jpk.2_Missense_Mutation_p.S271R	NM_000154	NP_000145	P51570	GALK1_HUMAN	galactokinase 1	271					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGCCCTCTTTGCTCACCAGGT	0.701													0	0	0	1	0	4	8										C	73754661	G	C	73754661	3	2	82	1	0	0	0	0	1	0	0	0	6203	1310	46	4	377	4	GALK1	17	73754661	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	738186	73754661	7440549	391	24775										
FBF1	85302	broad.mit.edu	37	chr17	73923539	73923539	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acaggagcctatggtaccttCagaggaaaacctcctgttct	9	11	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:73923539C>T	uc002jqc.2	-	8	704	c.430G>A	c.(430-432)GAA>AAA	p.E144K	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E134K|FBF1_uc002jqd.1_Missense_Mutation_p.E144K	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	144											0						ATGGTACCTTCAGAGGAAAAC	0.577													0	0	0	1	0	3	3										T	73923539	C	T	73923539	3	4	82	1	0	0	0	0	1	0	0	0	5695	835	29	1	3059	1	FBF1	17	73923539	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	168878	73923539	7271671	392	24776										
SRP68	6730	broad.mit.edu	37	chr17	74041408	74041408	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	accagagtcttgaggcctatCtctttctggaaggctttgtc	10	10	3	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:74041408C>T	uc002jqk.1	-	12	1394	c.1359G>A	c.(1357-1359)GAG>GAA	p.E453E	SRP68_uc010wsu.1_Silent_p.E352E|SRP68_uc002jql.1_Silent_p.E415E|SRP68_uc002jqj.1_Silent_p.E114E	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	453					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TGAGGCCTATCTCTTTCTGGA	0.463													0	0	0	1	0	30	46										T	74041408	C	T	74041408	2	4	82	1	0	0	0	0	0	0	0	1	15155	912	32	1		1	SRP68	17	74041408	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	117869	74041408	7153802	393	24777										
EXOC7	23265	broad.mit.edu	37	chr17	74093986	74093986	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tcctgggcctccagatcatcGtcaccactgatcagatccaa	7	15	3	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:74093986G>A	uc002jqs.2	-	5	626	c.531C>T	c.(529-531)GAC>GAT	p.D177D	EXOC7_uc010dgv.1_Silent_p.D124D|EXOC7_uc002jqq.2_Silent_p.D177D|EXOC7_uc010wsw.1_Silent_p.D177D|EXOC7_uc010wsx.1_Silent_p.D177D|EXOC7_uc002jqr.2_Silent_p.D177D|EXOC7_uc010wsv.1_Silent_p.D136D|EXOC7_uc002jqu.2_Silent_p.D177D	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	177					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			CCAGATCATCGTCACCACTGA	0.617													0	0	0	1	0	34	77										A	74093986	G	A	74093986	2	1	82	1	0	0	0	0	0	0	0	1	5310	1136	40	2		2	EXOC7	17	74093986	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	52578	74093986	7101224	394	24778										
RHBDF2	79651	broad.mit.edu	37	chr17	74474947	74474947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cacagacattctcttgcggcGtggcaggtgggagtagccag	15	10	1	1	rs138968491		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:74474947G>A	uc002jrq.1	-	6	993	c.700C>T	c.(700-702)CGC>TGC	p.R234C	RHBDF2_uc002jrp.1_Missense_Mutation_p.R205C|RHBDF2_uc002jrr.1_Missense_Mutation_p.R86C|RHBDF2_uc010wtf.1_Missense_Mutation_p.R205C|RHBDF2_uc002jrs.1_Missense_Mutation_p.R229C	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	234	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						CTCTTGCGGCGTGGCAGGTGG	0.687													0	0	0	1	0	17	28										A	74474947	G	A	74474947	3	1	82	1	0	0	0	0	1	0	0	0	13320	1145	40	2	1926	2	RHBDF2	17	74474947	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	380961	74474947	6720263	395	24779										
TMC6	11322	broad.mit.edu	37	chr17	76115385	76115385	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agaggaccctcaccaggtcaGagtctgcccataaatcagct	9	13	4	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr17:76115385G>A	uc002juj.1	-	13	1930	c.1804C>T	c.(1804-1806)CTG>TTG	p.L602L	TMC6_uc002jui.1_Silent_p.L181L|TMC6_uc010dhf.1_Silent_p.L435L|TMC6_uc002juk.2_Silent_p.L602L|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Silent_p.L602L	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	602	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CACCAGGTCAGAGTCTGCCCA	0.622									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	1	0	33	46										A	76115385	G	A	76115385	2	1	82	1	0	0	0	0	0	0	0	1	15986	933	33	1		1	TMC6	17	76115385	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1640438	76115385	5079825	396	24780										
TXNDC2	84203	broad.mit.edu	37	chr18	9888112	9888112	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcgcccttaaggaaaaacttGaagcagtcattgcagaatta	9	8	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:9888112G>A	uc002koi.3	+	2	2085	c.1636G>A	c.(1636-1638)GAA>AAA	p.E546K	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.E479K	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	546	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GGAAAAACTTGAAGCAGTCAT	0.378													0	0	0	1	0	11	21										A	9888112	G	A	9888112	3	1	82	1	0	0	0	0	1	0	0	0	16794	1291	45	1	1642	1	TXNDC2	18	9888112	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		9888112	68189136	397	24781										
CEP192	55125	broad.mit.edu	37	chr18	13057683	13057683	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcttaatccaactgaccgctGgctgcaagtcagcattgggg	12	11	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:13057683G>A	uc010xac.1	+	20	4288	c.4208G>A	c.(4207-4209)TGG>TAG	p.W1403*	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Nonsense_Mutation_p.W928*|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Nonsense_Mutation_p.W1144*	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1403										ovary(4)|pancreas(1)	5						ACTGACCGCTGGCTGCAAGTC	0.498													0	0	0	1	0	14	33										A	13057683	G	A	13057683	4	1	82	1	0	0	0	0	0	1	0	0	3251	1357	47	2	4282	2	CEP192	18	13057683	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3169571	13057683	65019565	398	24782										
ZNF521	25925	broad.mit.edu	37	chr18	22805210	22805210	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccatagtgtaggctgccccaCaaatgtcgcagccgtacata	9	13	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:22805210C>T	uc002kvk.2	-	4	2919	c.2672G>A	c.(2671-2673)TGT>TAT	p.C891Y	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.C891Y|ZNF521_uc002kvl.2_Missense_Mutation_p.C671Y	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	891	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGCTGCCCCACAAATGTCGCA	0.522			T	PAX5	ALL								0	0	0	1	0	41	71										T	22805210	C	T	22805210	3	4	82	1	0	0	0	0	1	0	0	0	17962	478	17	2	1283	2	ZNF521	18	22805210	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	9747527	22805210	55272038	399	24783										
DSC1	1823	broad.mit.edu	37	chr18	28714075	28714075	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aatcaagattttgccgttgaCgaagaatggcagttttacct	9	7	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:28714075C>T	uc002kwn.2	-	13	2157	c.1895G>A	c.(1894-1896)CGT>CAT	p.R632H	DSC1_uc002kwm.2_Missense_Mutation_p.R632H	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	632	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTGCCGTTGACGAAGAATGGC	0.348													0	0	0	1	0	31	30										T	28714075	C	T	28714075	3	4	82	1	0	0	0	0	1	0	0	0	4765	536	19	2	845	2	DSC1	18	28714075	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5908865	28714075	49363173	400	24784										
DSG3	1830	broad.mit.edu	37	chr18	29054237	29054237	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcttcaggattcggagcagCcactggagttggcatctgtt	13	9	2	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:29054237C>T	uc002kws.2	+	15	2364	c.2255C>T	c.(2254-2256)GCC>GTC	p.A752V	DSG3_uc002kwt.2_Missense_Mutation_p.A34V	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	752	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTCGGAGCAGCCACTGGAGTT	0.537													0	0	0	1	0	41	29										T	29054237	C	T	29054237	3	4	82	1	0	0	0	0	1	0	0	0	4778	739	26	2	2313	2	DSG3	18	29054237	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	340162	29054237	49023011	401	24785										
MAPRE2	10982	broad.mit.edu	37	chr18	32682030	32682030	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agtatgatcctgtagaggcaCgacaagggcaagatgcaatt	12	7	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:32682030C>T	uc002kyg.2	+	4	697	c.517C>T	c.(517-519)CGA>TGA	p.R173*	MAPRE2_uc010xcb.1_Nonsense_Mutation_p.R130*|MAPRE2_uc010xcc.1_Nonsense_Mutation_p.R161*|MAPRE2_uc002kyf.2_Nonsense_Mutation_p.R173*|MAPRE2_uc002kyh.2_Nonsense_Mutation_p.R120*|MAPRE2_uc010xcd.1_Nonsense_Mutation_p.R130*	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	173					cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						TGTAGAGGCACGACAAGGGCA	0.453													0	0	0	1	0	18	14										T	32682030	C	T	32682030	4	4	82	1	0	0	0	0	0	1	0	0	9295	528	19	2	625	2	MAPRE2	18	32682030	Nonsense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3627793	32682030	45395218	402	24786										
KIAA1468	57614	broad.mit.edu	37	chr18	59888694	59888694	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttgaagaataactataagctTacatcaataaccttttcaga	4	7	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr18:59888694T>G	uc002lil.2	+	5	1037	c.822T>G	c.(820-822)CTT>CTG	p.L274L	KIAA1468_uc002lik.1_Silent_p.L274L|KIAA1468_uc010xel.1_Silent_p.L274L|KIAA1468_uc002lim.2_5'UTR	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	274	LisH.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				ACTATAAGCTTACATCAATAA	0.294													0	0	0	1	0	30	17										G	59888694	T	G	59888694	2	3	82	1	0	0	0	0	0	0	0	1	8236	1741	61	5		5	KIAA1468	18	59888694	Silent	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	27206664	59888694	18188554	403	24787										
MED16	10025	broad.mit.edu	37	chr19	876999	876999	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcagggcagcggtctggcgcGtgtactcctcgtgcagcttc	15	13	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:876999G>T	uc002lqd.1	-	9	1686	c.1535C>A	c.(1534-1536)ACG>AAG	p.T512K	MED16_uc010drw.1_Missense_Mutation_p.T337K|MED16_uc002lqe.2_Missense_Mutation_p.T501K|MED16_uc002lqf.2_Missense_Mutation_p.T501K|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Intron|MED16_uc010xfx.1_Missense_Mutation_p.T357K|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	512					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCTGGCGCGTGTACTCCTC	0.697													1	0	0.00909568	1	0.00912667	4	3										T	876999	G	T	876999	3	4	82	1	0	0	0	0	1	0	0	0	9434	1145	40	4	1130	4	MED16	19	876999	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		876999	58251984	404	24788										
SLC25A41	284427	broad.mit.edu	37	chr19	6427193	6427193	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtcgtggatagcgtcacagaCgacagactgaccaggccact	12	12	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:6427193C>T	uc010dus.2	-	6	947	c.861G>A	c.(859-861)TCG>TCA	p.S287S	KHSRP_uc002mer.3_5'Flank|SLC25A41_uc010dut.2_Silent_p.S149S	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	287	Solcar 3.|Helical; Name=5; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						GCGTCACAGACGACAGACTGA	0.627													0	0	0	1	0	3	5										T	6427193	C	T	6427193	2	4	82	1	0	0	0	0	0	0	0	1	14506	523	19	2		2	SLC25A41	19	6427193	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	5550194	6427193	52701790	405	24789										
ZNF557	79230	broad.mit.edu	37	chr19	7075710	7075710	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctcagcgagaaggacacacaGagggcggagagctggttaat	15	8	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:7075710G>A	uc002mgb.2	+	4	540	c.55G>A	c.(55-57)GAG>AAG	p.E19K	ZNF557_uc002mga.2_Missense_Mutation_p.E26K|ZNF557_uc002mgc.2_Missense_Mutation_p.E26K	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	19					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		AGGACACACAGAGGGCGGAGA	0.522													0	0	0	1	0	30	16										A	7075710	G	A	7075710	3	1	82	1	0	0	0	0	1	0	0	0	17985	943	33	1	82	1	ZNF557	19	7075710	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	648517	7075710	52053273	406	24790										
CCDC151	115948	broad.mit.edu	37	chr19	11533473	11533473	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtctgctcgttctcgctcttGagcgtctccaactgcgcgaa	10	14	4	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:11533473G>A	uc002mrs.2	-	9	1316	c.1173C>T	c.(1171-1173)CTC>CTT	p.L391L	CCDC151_uc002mrr.2_Silent_p.L326L|CCDC151_uc010dxz.2_Silent_p.L331L	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	391	Potential.									ovary(1)	1						TCTCGCTCTTGAGCGTCTCCA	0.657													0	0	0	1	0	11	7										A	11533473	G	A	11533473	2	1	82	1	0	0	0	0	0	0	0	1	2786	1277	45	1		1	CCDC151	19	11533473	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	4457763	11533473	47595510	407	24791										
CACNA1A	773	broad.mit.edu	37	chr19	13411423	13411423	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tctgccacctccttggctttCtgtagggcaagtttctggtt	10	11	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:13411423C>T	uc010dze.2	-	18	2459	c.2223G>A	c.(2221-2223)CAG>CAA	p.Q741Q	CACNA1A_uc010dzc.2_Silent_p.Q266Q|CACNA1A_uc002mwy.3_Silent_p.Q740Q|CACNA1A_uc010xne.1_Silent_p.Q269Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	741	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTTGGCTTTCTGTAGGGCAA	0.522													0	0	0	1	0	5	66										T	13411423	C	T	13411423	2	4	82	1	0	0	0	0	0	0	0	1	2538	912	32	1		1	CACNA1A	19	13411423	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1877950	13411423	45717560	408	24792										
OR7A5	26659	broad.mit.edu	37	chr19	14938996	14938996	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaagggttgcagtccaggttCttgtgaaaatcccagaagaa	12	7	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:14938996C>T	uc002mzw.2	-	1	281	c.58G>A	c.(58-60)GAA>AAA	p.E20K	OR7A5_uc010xoa.1_Missense_Mutation_p.E20K	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						AGTCCAGGTTCTTGTGAAAAT	0.458													0	0	0	1	0	24	20										T	14938996	C	T	14938996	3	4	82	1	0	0	0	0	1	0	0	0	11216	922	32	1	905	1	OR7A5	19	14938996	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1527573	14938996	44189987	409	24793										
EPHX3	79852	broad.mit.edu	37	chr19	15342144	15342157	+	Frame_Shift_Del	DEL	CAAGTCCACAGCCA	CAAGTCCACAGCCA	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tccgaggggccatagcctcgCaagtccacagccacaacatg							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:15342144_15342157delCAAGTCCACAGCCA	uc002nap.2	-	3	589_602	c.380_393delTGGCTGTGGACTTG	c.(379-393)GTGGCTGTGGACTTGfs	p.V127fs	EPHX3_uc002naq.2_Frame_Shift_Del_p.V127fs	NM_024794	NP_079070	Q9H6B9	EPHX3_HUMAN	abhydrolase domain containing 9 precursor	127_131						extracellular region	hydrolase activity				0						CATAGCCTCGCAAGTCCACAGCCACAACATGGAA	0.621																		11	49	---	---								-	15342157	CAAGTCCACAGCCA	-	15342144	7	5	82	1	0	1	0	1	0	0	0	0	5181	709	25	0	709	0	EPHX3	19	15342144	Frame_Shift_Del	DEL	CAAGTCCACAGCCA	TCGA-FD-A3SN-01A-12D-A22Z-08	403148	15342144	43786839	410	24794										
RASAL3	64926	broad.mit.edu	37	chr19	15562865	15562865	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggcaatctcaccaggtttttCagactgtgcccttcattgct	8	12	3	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:15562865C>T	uc002nbe.2	-	17	2969	c.2883G>A	c.(2881-2883)CTG>CTA	p.L961L	WIZ_uc002nbb.3_5'Flank|RASAL3_uc002nbd.2_3'UTR|RASAL3_uc010eaa.1_Intron	NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	961	Potential.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						CCAGGTTTTTCAGACTGTGCC	0.577													0	0	0	1	0	25	45										T	15562865	C	T	15562865	2	4	82	1	0	0	0	0	0	0	0	1	13065	813	29	1		1	RASAL3	19	15562865	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	220721	15562865	43566118	411	24795										
FCHO1	23149	broad.mit.edu	37	chr19	17877494	17877499	+	In_Frame_Del	DEL	TGGGAG	TGGGAG	-													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccaggaccttcgccccgctcTgggaggtcttccgcgtctcc							TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:17877494_17877499delTGGGAG	uc010ebb.2	+	6	400_405	c.211_216delTGGGAG	c.(211-216)TGGGAGdel	p.WE71del	FCHO1_uc002nhg.3_In_Frame_Del_p.WE71del|FCHO1_uc002nhh.2_In_Frame_Del_p.WE71del|FCHO1_uc010xpw.1_In_Frame_Del_p.WE21del|FCHO1_uc010ebc.1_In_Frame_Del_p.WE78del	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	71_72	FCH.									breast(1)	1						CGCCCCGCTCTGGGAGGTCTTCCGCG	0.621																		8	20	---	---								-	17877499	TGGGAG	-	17877494	7	5	82	1	0	1	0	1	0	0	0	0	5787	1580	55	0	225	0	FCHO1	19	17877494	In_Frame_Del	DEL	TGGGAG	TCGA-FD-A3SN-01A-12D-A22Z-08	2314629	17877494	41251489	412	24796										
CILP2	148113	broad.mit.edu	37	chr19	19650526	19650526	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	agccaatggcgactgcactgGgcctggaaagacggtccgtg	15	11	0	1	rs142743091		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:19650526G>T	uc002nmv.3	+	2	188	c.103G>T	c.(103-105)GGC>TGC	p.G35C	CILP2_uc002nmw.3_Missense_Mutation_p.G35C	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	35						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GACTGCACTGGGCCTGGAAAG	0.667													1	0	1.42536e-11	1	1.48066e-11	23	62										T	19650526	G	T	19650526	3	4	82	1	0	0	0	0	1	0	0	0	3430	1232	43	4	109	4	CILP2	19	19650526	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1773032	19650526	39478457	413	24797										
ZNF714	148206	broad.mit.edu	37	chr19	21300833	21300833	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gagagaaaccctacaaatgtGaagaatgtggcaaagctttc	10	7	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:21300833G>A	uc002npo.3	+	6	1726	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	ZNF714_uc002npl.2_Missense_Mutation_p.E301K|ZNF714_uc010ecp.1_Missense_Mutation_p.E407K|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	456	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACAAATGTGAAGAATGTGG	0.368													0	0	0	1	0	21	43										A	21300833	G	A	21300833	3	1	82	1	0	0	0	0	1	0	0	0	18115	1291	45	1	1373	1	ZNF714	19	21300833	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1650307	21300833	37828150	414	24798										
UPK1A	11045	broad.mit.edu	37	chr19	36159496	36159496	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ttctgcggcttctccttcttCatggtagccagttttggtgt	10	10	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:36159496C>T	uc002oaw.2	+	2	225	c.225C>T	c.(223-225)TTC>TTT	p.F75F	UPK1A_uc010eeh.2_Silent_p.F75F|uc002oax.1_Missense_Mutation_p.M17I	NM_007000	NP_008931	O00322	UPK1A_HUMAN	uroplakin 1A	75	Helical; (Potential).				epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCCTTCTTCATGGTAGCCA	0.597													0	0	0	1	0	7	13										T	36159496	C	T	36159496	2	4	82	1	0	0	0	0	0	0	0	1	17004	825	29	1		1	UPK1A	19	36159496	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	14858663	36159496	22969487	415	24799										
MLL4	9757	broad.mit.edu	37	chr19	36214671	36214671	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgctgttgccctgggattccGatgaatctcctgaggcctcc	11	14	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:36214671G>A	uc010eei.2	+	9	3097	c.3097G>A	c.(3097-3099)GAT>AAT	p.D1033N		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1033					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGGGATTCCGATGAATCTCC	0.672													0	0	0	1	0	5	8										A	36214671	G	A	36214671	3	1	82	1	0	0	0	0	1	0	0	0	9623	1058	37	1	3127	1	MLL4	19	36214671	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	55175	36214671	22914312	416	24800										
TMEM149	79713	broad.mit.edu	37	chr19	36231306	36231306	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcagcgccacggggttctgCccccgcccgcggcgggagta	16	16	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:36231306C>T	uc002obc.2	-	3	418	c.317G>A	c.(316-318)GGC>GAC	p.G106D	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Missense_Mutation_p.G106D|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.G186D	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	106	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGGGTTCTGCCCCCGCCCGC	0.706													0	0	0	1	0	5	20										T	36231306	C	T	36231306	3	4	82	1	0	0	0	0	1	0	0	0	16059	739	26	2	762	2	TMEM149	19	36231306	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	16635	36231306	22897677	417	24801										
SUPT5H	6829	broad.mit.edu	37	chr19	39936594	39936594	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcgagcgcagcagtgacggcGaggaggccgaggtctgtggc	20	10	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:39936594G>A	uc002olo.3	+	2	243	c.64G>A	c.(64-66)GAG>AAG	p.E22K	SUPT5H_uc010xvb.1_Missense_Mutation_p.E22K|SUPT5H_uc002olp.3_Missense_Mutation_p.E22K|SUPT5H_uc002olq.3_Missense_Mutation_p.E22K|SUPT5H_uc002oln.3_Missense_Mutation_p.E22K|SUPT5H_uc002olr.3_Missense_Mutation_p.E22K	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	22	Glu-rich.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGTGACGGCGAGGAGGCCGA	0.657													0	0	0	1	0	6	16										A	39936594	G	A	39936594	3	1	82	1	0	0	0	0	1	0	0	0	15396	1059	37	1	66	1	SUPT5H	19	39936594	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3705288	39936594	19192389	418	24802										
GSK3A	2931	broad.mit.edu	37	chr19	42744259	42744259	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcgctctgggccttggcctaGagtggctacgactgtggtca	15	11	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:42744259G>A	uc002otb.1	-	2	438	c.319C>T	c.(319-321)CTA>TTA	p.L107L	GSK3A_uc002ota.1_Silent_p.L25L|GSK3A_uc002otc.2_RNA	NM_019884	NP_063937	P49840	GSK3A_HUMAN	glycogen synthase kinase 3 alpha	107					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of transferase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process	beta-catenin destruction complex|cytosol	ATP binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|tau-protein kinase activity			ovary(2)|lung(2)	4		Prostate(69;0.00682)				CCTTGGCCTAGAGTGGCTACG	0.587													0	0	0	1	0	18	40										A	42744259	G	A	42744259	2	1	82	1	0	0	0	0	0	0	0	1	6823	933	33	1		1	GSK3A	19	42744259	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2807665	42744259	16384724	419	24803										
MEGF8	1954	broad.mit.edu	37	chr19	42839208	42839208	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccctgggaccatgccgctgtGagcctggcttcttgggacgt	14	13	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:42839208G>A	uc002otl.3	+	4	1215	c.580G>A	c.(580-582)GAG>AAG	p.E194K	MEGF8_uc002otm.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	194	Extracellular (Potential).|EGF-like 2.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				ATGCCGCTGTGAGCCTGGCTT	0.478													0	0	0	1	0	9	16										A	42839208	G	A	42839208	3	1	82	1	0	0	0	0	1	0	0	0	9463	1291	45	1	594	1	MEGF8	19	42839208	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	94949	42839208	16289775	420	24804										
KLC3	147700	broad.mit.edu	37	chr19	45852790	45852790	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgtggagcggcactatgcccGggccctgagcatctatgagg	15	12	1	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:45852790G>C	uc002pbf.1	+	8	1188	c.1073G>C	c.(1072-1074)CGG>CCG	p.R358P	KLC3_uc010ejy.1_Missense_Mutation_p.R357P|KLC3_uc002pbg.1_Missense_Mutation_p.R372P	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	358	TPR 4.					cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CACTATGCCCGGGCCCTGAGC	0.637													0	0	0	1	0	11	60										C	45852790	G	C	45852790	3	2	82	1	0	0	0	0	1	0	0	0	8335	1116	39	4	1099	4	KLC3	19	45852790	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3013582	45852790	13276193	421	24805										
ERCC2	2068	broad.mit.edu	37	chr19	45872219	45872219	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctggcacagttcttgagcagTagatgagtttggtcacctcc	11	10	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:45872219T>C	uc002pbj.2	-	4	262	c.215A>G	c.(214-216)TAC>TGC	p.Y72C	ERCC2_uc010ejz.2_Missense_Mutation_p.Y72C|ERCC2_uc002pbk.2_Missense_Mutation_p.Y48C|ERCC2_uc002pbl.3_Missense_Mutation_p.Y48C|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	72	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TCTTGAGCAGTAGATGAGTTT	0.577			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	28	50										C	45872219	T	C	45872219	3	2	82	1	0	0	0	0	1	0	0	0	5213	1638	57	5	2204	5	ERCC2	19	45872219	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	19429	45872219	13256764	422	24806										
CCDC8	83987	broad.mit.edu	37	chr19	46914757	46914757	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgattatgtgcagcctctgcCctctggccagcccgggcctg	12	15	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:46914757C>T	uc002pep.2	-	1	2163	c.1311G>A	c.(1309-1311)AGG>AGA	p.R437R		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	437						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		CAGCCTCTGCCCTCTGGCCAG	0.612													0	0	0	1	0	31	53										T	46914757	C	T	46914757	2	4	82	1	0	0	0	0	0	0	0	1	2853	622	22	2		2	CCDC8	19	46914757	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1042538	46914757	12214226	423	24807										
SULT2A1	6822	broad.mit.edu	37	chr19	48374720	48374720	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtgttttggacgttattcccAtgggaacagctctcgaggaa	12	8	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:48374720A>G	uc002phr.2	-	6	990	c.850T>C	c.(850-852)TGG>CGG	p.W284R		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	284					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		CGTTATTCCCATGGGAACAGC	0.433													0	0	0	1	0	15	34										G	48374720	A	G	48374720	3	3	82	1	0	0	0	0	1	0	0	0	15378	217	8	5	11	5	SULT2A1	19	48374720	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	1459963	48374720	10754263	424	24808										
SPHK2	56848	broad.mit.edu	37	chr19	49132163	49132163	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctgggcacggtgctgggcctCgccacactgcacacctaccg	12	17	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:49132163C>T	uc002pjr.2	+	7	1464	c.1098C>T	c.(1096-1098)CTC>CTT	p.L366L	SPHK2_uc010xzt.1_Silent_p.L307L|SPHK2_uc002pjs.2_Silent_p.L366L|SPHK2_uc002pjt.2_Silent_p.L160L|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.L330L|SPHK2_uc002pjw.2_Silent_p.L428L	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	366					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TGCTGGGCCTCGCCACACTGC	0.667													0	0	0	1	0	32	43										T	49132163	C	T	49132163	2	4	82	1	0	0	0	0	0	0	0	1	15046	871	31	1		1	SPHK2	19	49132163	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	757443	49132163	9996820	425	24809										
RCN3	57333	broad.mit.edu	37	chr19	50046469	50046469	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccggcaccacgatgagctgtGagcaccgcgcacctgccaca	11	17	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50046469G>A	uc002poj.2	+	7	1433	c.986G>A	c.(985-987)TGA>TAA	p.*329*		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	329						endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GATGAGCTGTGAGCACCGCGC	0.652													0	0	0	1	0	8	10										A	50046469	G	A	50046469	2	1	82	1	0	0	0	0	0	0	0	1	13181	1285	45	1		1	RCN3	19	50046469	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	914306	50046469	9082514	426	24810										
RRAS	6237	broad.mit.edu	37	chr19	50139972	50139972	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atctgcgtgaagagcttgccCacctcgttgaaactgcgagt	11	11	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50139972C>A	uc002pop.1	-	4	402	c.357G>T	c.(355-357)GTG>GTT	p.V119V		NM_006270	NP_006261	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	119					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		AGAGCTTGCCCACCTCGTTGA	0.627													1	0	5.3912e-06	1	5.4938e-06	17	31										A	50139972	C	A	50139972	2	1	82	1	0	0	0	0	0	0	0	1	13676	581	21	4		4	RRAS	19	50139972	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	93503	50139972	8989011	427	24811										
TSKS	60385	broad.mit.edu	37	chr19	50243401	50243401	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagggtggagctcagggcctCtgccctgacgtgtttggcta	15	10	2	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50243401C>T	uc002ppm.2	-	10	1548	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	513							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CTCAGGGCCTCTGCCCTGACG	0.647													0	0	0	1	0	22	65										T	50243401	C	T	50243401	3	4	82	1	0	0	0	0	1	0	0	0	16623	922	32	1	249	1	TSKS	19	50243401	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	103429	50243401	8885582	428	24812										
FUZ	80199	broad.mit.edu	37	chr19	50315567	50315567	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cagctcagagatgcccacctCagatgacagaacaatgaggg	11	11	2	5			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:50315567C>T	uc002ppq.1	-	3	364	c.259G>A	c.(259-261)GAG>AAG	p.E87K	FUZ_uc002ppr.1_5'UTR|FUZ_uc002pps.1_Intron|FUZ_uc002ppt.1_Intron|FUZ_uc002ppu.1_Intron|FUZ_uc002ppv.1_Missense_Mutation_p.E37K|FUZ_uc010ybd.1_Missense_Mutation_p.E87K	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	87					cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		ATGCCCACCTCAGATGACAGA	0.423													0	0	0	1	0	6	28										T	50315567	C	T	50315567	3	4	82	1	0	0	0	0	1	0	0	0	6112	835	29	1	1033	1	FUZ	19	50315567	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	72166	50315567	8813416	429	24813										
SIGLEC5	8778	broad.mit.edu	37	chr19	52132666	52132666	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	acctgagctccttggcgtttCatctgacaggtgaggttggt	13	9	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:52132666C>T	uc002pxe.2	-	3	784	c.645G>A	c.(643-645)ATG>ATA	p.M215I		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	215	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CTTGGCGTTTCATCTGACAGG	0.632													0	0	0	1	0	13	38										T	52132666	C	T	52132666	3	4	82	1	0	0	0	0	1	0	0	0	14311	826	29	1	1038	1	SIGLEC5	19	52132666	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1817099	52132666	6996317	430	24814										
ZNF665	79788	broad.mit.edu	37	chr19	53668818	53668818	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ctccccagtatgaattcttcGatgacttgcaaggtgtgaat	9	9	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr19:53668818G>A	uc010eqm.1	-	4	1025	c.925C>T	c.(925-927)CGA>TGA	p.R309*		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	244	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TGAATTCTTCGATGACTTGCA	0.428													0	0	0	1	0	59	136										A	53668818	G	A	53668818	4	1	82	1	0	0	0	0	0	1	0	0	18070	1066	37	1	1115	1	ZNF665	19	53668818	Nonsense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1536152	53668818	5460165	431	24815										
SIRPB2	284759	broad.mit.edu	37	chr20	1458977	1458977	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gggtttcctctgaaactttaCacagtaataggtgcctgcat	9	9	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:1458977C>T	uc002wfg.2	-	3	955	c.727G>A	c.(727-729)GTA>ATA	p.V243I	SIRPB2_uc002wfh.3_Missense_Mutation_p.V145I|SIRPB2_uc010zpr.1_Missense_Mutation_p.V105I	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	243	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0						TGAAACTTTACACAGTAATAG	0.512													0	0	0	1	0	24	48										T	1458977	C	T	1458977	3	4	82	1	0	0	0	0	1	0	0	0	14334	478	17	2	313	2	SIRPB2	20	1458977	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		1458977	61566543	432	24816										
STK35	140901	broad.mit.edu	37	chr20	2083843	2083843	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcgacgcccccgagaacgtgGagctggcgctggctgaattc	15	13	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:2083843G>A	uc010gak.2	+	2	724	c.724G>A	c.(724-726)GAG>AAG	p.E242K	STK35_uc010zpu.1_Missense_Mutation_p.E109K|STK35_uc002wfw.3_Missense_Mutation_p.E109K	NM_080836	NP_543026	Q8TDR2	STK35_HUMAN	serine/threonine kinase 35	242	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CGAGAACGTGGAGCTGGCGCT	0.682													0	0	0	1	0	5	11										A	2083843	G	A	2083843	3	1	82	1	0	0	0	0	1	0	0	0	15300	1175	41	1	730	1	STK35	20	2083843	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	624866	2083843	60941677	433	24817										
HSPA12B	116835	broad.mit.edu	37	chr20	3732653	3732653	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cggcgcgctcagcctcgagcTtgagcccgccgactgcggcc	14	18	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:3732653T>A	uc002wjd.2	+	13	2004	c.1901T>A	c.(1900-1902)CTT>CAT	p.L634H	HSPA12B_uc010zqi.1_Missense_Mutation_p.L633H|HSPA12B_uc002wje.2_Missense_Mutation_p.L547H|HSPA12B_uc010zqj.1_Missense_Mutation_p.L468H	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	634							ATP binding				0						AGCCTCGAGCTTGAGCCCGCC	0.697													0	0	0	1	0	5	7										A	3732653	T	A	3732653	3	1	82	1	0	0	0	0	1	0	0	0	7405	1609	56	5	1947	5	HSPA12B	20	3732653	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08	1648810	3732653	59292867	434	24818										
RASSF2	9770	broad.mit.edu	37	chr20	4768393	4768393	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taatcggtggccttcagcttCtgtttctctgcaaccacaca	7	13	3	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:4768393C>T	uc002wld.2	-	9	753	c.699G>A	c.(697-699)CAG>CAA	p.Q233Q	RASSF2_uc002wlc.2_Intron|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Silent_p.Q233Q|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	233	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						CCTTCAGCTTCTGTTTCTCTG	0.542													0	0	0	1	0	16	21										T	4768393	C	T	4768393	2	4	82	1	0	0	0	0	0	0	0	1	13086	912	32	1		1	RASSF2	20	4768393	Silent	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	1035740	4768393	58257127	435	24819										
PLCB1	23236	broad.mit.edu	37	chr20	8722214	8722214	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaagatgaagaagaagtaaaGaaagaggtgagagggtgttt	16	0	0	7			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:8722214G>C	uc002wnb.2	+	23	2520	c.2517G>C	c.(2515-2517)AAG>AAC	p.K839N	PLCB1_uc010zrb.1_Missense_Mutation_p.K738N|PLCB1_uc002wna.2_Missense_Mutation_p.K839N|PLCB1_uc002wnc.1_Missense_Mutation_p.K738N|PLCB1_uc002wnd.1_Missense_Mutation_p.K416N	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	839					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AAGAAGTAAAGAAAGAGGTGA	0.398													0	0	0	1	0	5	20										C	8722214	G	C	8722214	3	2	82	1	0	0	0	0	1	0	0	0	12027	933	33	1	2607	1	PLCB1	20	8722214	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3953821	8722214	54303306	436	24820										
C20orf3	57136	broad.mit.edu	37	chr20	24973288	24973288	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgtgacgacctgcggccgcaGgggccggcgctgtcgcagcc	17	15	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:24973288G>C	uc002wty.2	-	1	138	c.37C>G	c.(37-39)CTG>GTG	p.L13V	C20orf3_uc002wtz.2_Missense_Mutation_p.L13V|C20orf3_uc010zsw.1_Missense_Mutation_p.L13V	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	13	Cytoplasmic (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						TGCGGCCGCAGGGGCCGGCGC	0.716													0	0	0	1	0	4	1										C	24973288	G	C	24973288	3	2	82	1	0	0	0	0	1	0	0	0	2109	991	35	4	1249	4	C20orf3	20	24973288	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	16251074	24973288	38052232	437	24821										
ACSS1	84532	broad.mit.edu	37	chr20	25038496	25038496	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tggtagggggtgtcccacacGagagtgtcccgcgccagagg	17	11	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:25038496G>A	uc002wub.2	-	1	1121	c.243C>T	c.(241-243)CTC>CTT	p.L81L	ACSS1_uc002wuc.2_Silent_p.L81L|ACSS1_uc010gdc.2_Silent_p.L81L	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	81					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGTCCCACACGAGAGTGTCCC	0.657													0	0	0	1	0	18	31										A	25038496	G	A	25038496	2	1	82	1	0	0	0	0	0	0	0	1	188	1045	37	1		1	ACSS1	20	25038496	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	65208	25038496	37987024	438	24822										
C20orf134	170487	broad.mit.edu	37	chr20	32255571	32255571	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcagctgctacgtgtccctgGacttcgagggcgacctccgc	13	15	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:32255571G>A	uc002wzt.2	+	1	1268	c.268G>A	c.(268-270)GAC>AAC	p.D90N	NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron	NM_001024675	NP_001019846	Q5JWF8	CT134_HUMAN	hypothetical protein LOC170487	90										pancreas(1)	1						CGTGTCCCTGGACTTCGAGGG	0.672													0	0	0	1	0	14	18										A	32255571	G	A	32255571	3	1	82	1	0	0	0	0	1	0	0	0	2087	1174	41	1	270	1	C20orf134	20	32255571	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	7217075	32255571	30769949	439	24823										
MYH7B	57644	broad.mit.edu	37	chr20	33574708	33574708	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gacatgctgcttctgtctatGaacccctatgactaccactt	6	13	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:33574708G>A	uc002xbi.1	+	13	1142	c.1050G>A	c.(1048-1050)ATG>ATA	p.M350I		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	308	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TTCTGTCTATGAACCCCTATG	0.567													0	0	0	1	0	26	33										A	33574708	G	A	33574708	3	1	82	1	0	0	0	0	1	0	0	0	10040	1290	45	1	1100	1	MYH7B	20	33574708	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1319137	33574708	29450812	440	24824										
SPAG4	6676	broad.mit.edu	37	chr20	34204137	34204137	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gggagtgcccggaggaaccaCatgggcaggaagctctcagc	16	11	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:34204137C>T	uc002xdb.1	+	1	329	c.212C>T	c.(211-213)ACA>ATA	p.T71I	SPAG4_uc010zvi.1_5'UTR	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	71					spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GGAGGAACCACATGGGCAGGA	0.741													0	0	0	1	0	7	10										T	34204137	C	T	34204137	3	4	82	1	0	0	0	0	1	0	0	0	14980	478	17	2	214	2	SPAG4	20	34204137	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	629429	34204137	28821383	441	24825										
CTNNBL1	56259	broad.mit.edu	37	chr20	36322537	36322537	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cgggtaccatggacgtgggcGaacttctgagctaccaggta	14	10	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:36322537G>A	uc010zvw.1	+	1	104	c.13G>A	c.(13-15)GAA>AAA	p.E5K	CTNNBL1_uc010zvv.1_5'UTR	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	5					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				GGACGTGGGCGAACTTCTGAG	0.662													0	0	0	1	0	3	6										A	36322537	G	A	36322537	3	1	82	1	0	0	0	0	1	0	0	0	4018	1059	37	1	15	1	CTNNBL1	20	36322537	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2118400	36322537	26702983	442	24826										
CHD6	84181	broad.mit.edu	37	chr20	40049589	40049589	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccttgagatgttagtagtggGctccgtgagatgcaatacct	12	8	0	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:40049589G>T	uc002xka.1	-	31	5864	c.5686C>A	c.(5686-5688)CCC>ACC	p.P1896T		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1896					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTAGTAGTGGGCTCCGTGAGA	0.418													1	0	3.3946e-10	1	3.50775e-10	39	42										T	40049589	G	T	40049589	3	4	82	1	0	0	0	0	1	0	0	0	3329	1203	42	4	2489	4	CHD6	20	40049589	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3727052	40049589	22975931	443	24827										
YWHAB	7529	broad.mit.edu	37	chr20	43530229	43530229	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ccaaactcgctgagcaggctGagcgatatgatgatatggct	12	9	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:43530229G>A	uc002xmt.2	+	3	337	c.55G>A	c.(55-57)GAG>AAG	p.E19K	YWHAB_uc002xmu.2_Missense_Mutation_p.E19K	NM_003404	NP_003395	P31946	1433B_HUMAN	tyrosine 3-monooxygenase/tryptophan	19					activation of MAPKK activity|activation of pro-apoptotic gene products|axon guidance|cytoplasmic sequestering of protein|epidermal growth factor receptor signaling pathway|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|mRNA metabolic process|negative regulation of protein dephosphorylation|nerve growth factor receptor signaling pathway|Ras protein signal transduction	centrosome|cytosol|melanosome|perinuclear region of cytoplasm	histone deacetylase binding|phosphoserine binding|protein domain specific binding			kidney(2)|ovary(1)|breast(1)	4		Myeloproliferative disorder(115;0.0122)				TGAGCAGGCTGAGCGATATGA	0.458													0	0	0	1	0	23	24										A	43530229	G	A	43530229	3	1	82	1	0	0	0	0	1	0	0	0	17498	1291	45	1	57	1	YWHAB	20	43530229	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	3480640	43530229	19495291	444	24828										
PCIF1	63935	broad.mit.edu	37	chr20	44573628	44573628	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggagtacgtcaaacggatccGagagaagcaccttgccatcc	11	12	1	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr20:44573628G>A	uc002xqs.2	+	11	1441	c.1127G>A	c.(1126-1128)CGA>CAA	p.R376Q	PCIF1_uc002xqt.2_5'UTR|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	376						nucleus				skin(1)	1						AAACGGATCCGAGAGAAGCAC	0.562													0	0	0	1	0	13	4										A	44573628	G	A	44573628	3	1	82	1	0	0	0	0	1	0	0	0	11580	1058	37	1	1161	1	PCIF1	20	44573628	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	1043399	44573628	18451892	445	24829										
GCFC1	94104	broad.mit.edu	37	chr21	34120941	34120941	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgcttcaaactgtgatttaaTacagtcaattgaatagaaac	6	6	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:34120941T>C	uc002yqn.2	-	11	1982	c.1792A>G	c.(1792-1794)ATT>GTT	p.I598V	GCFC1_uc002yql.2_Missense_Mutation_p.I107V|GCFC1_uc002yqm.2_Missense_Mutation_p.I92V|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.I598V	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	598						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TGTGATTTAATACAGTCAATT	0.358													0	0	0	1	0	50	16										C	34120941	T	C	34120941	3	2	82	1	0	0	0	0	1	0	0	0	6289	1406	49	5	1111	5	GCFC1	21	34120941	Missense_Mutation	SNP	T	TCGA-FD-A3SN-01A-12D-A22Z-08		34120941	14008954	446	24830										
CRYZL1	9946	broad.mit.edu	37	chr21	34962153	34962153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	attgaacaacttgcttttttCttccttgatttttctgaaca	4	8	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:34962153C>G	uc011adw.1	-	13	1205	c.1025G>C	c.(1024-1026)AGA>ACA	p.R342T	DONSON_uc002ysn.1_Intron|DONSON_uc002ysj.2_5'Flank|DONSON_uc002ysk.2_5'Flank|DONSON_uc002ysl.2_5'Flank|DONSON_uc010gme.2_5'Flank|DONSON_uc002ysm.2_5'UTR	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	342					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						TTGCTTTTTTCTTCCTTGATT	0.353													0	0	0	1	0	24	12										G	34962153	C	G	34962153	3	3	82	1	0	0	0	0	1	0	0	0	3923	913	32	1	28	1	CRYZL1	21	34962153	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	841212	34962153	13167742	447	24831										
RSPH1	89765	broad.mit.edu	37	chr21	43913146	43913146	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	tgggtagccgtgccctcccaCgtccgtgcctttcgcctgcc	11	18	0	0	rs145742147	byFrequency	TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:43913146C>T	uc002zbg.2	-	2	203	c.98G>A	c.(97-99)CGT>CAT	p.R33H	SLC37A1_uc002zbh.1_5'Flank	NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	33	MORN 1.				meiosis	cytosol|nucleus				ovary(1)	1						TGCCCTCCCACGTCCGTGCCT	0.448													0	0	0	1	0	137	58										T	43913146	C	T	43913146	3	4	82	1	0	0	0	0	1	0	0	0	13702	536	19	2	863	2	RSPH1	21	43913146	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	8950993	43913146	4216749	448	24832										
PCNT	5116	broad.mit.edu	37	chr21	47821561	47821562	+	Missense_Mutation	DNP	TC	TC	GA													0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcagatgtcccgagcctcctTcgggcagccctcctgagggt					rs147564798		TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr21:47821561_47821562TC>GA	uc002zji.3	+	26	4995_4996	c.4888_4889TC>GA	c.(4888-4890)TCG>GAG	p.S1630E	PCNT_uc002zjj.2_Missense_Mutation_p.S1512E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1630	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CGAGCCTCCTTCGGGCAGCCCT	0.554													0	0	0	1	0	55	50										GA	47821562	TC	GA	47821561	3	3	82	1	0	0	0	0	1	0	0	0	11590	1783	62	5	4990	5	PCNT	21	47821561	Missense_Mutation	DNP	TC	TCGA-FD-A3SN-01A-12D-A22Z-08	3908415	47821561	308334	449	24833										
SERPIND1	3053	broad.mit.edu	37	chr22	21134339	21134339	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	taagagagtattactttgctGaggcccagatagctgacttc	10	8	0	4			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:21134339G>A	uc002ztb.1	+	2	806	c.739G>A	c.(739-741)GAG>AAG	p.E247K	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.E275K	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	247					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TTACTTTGCTGAGGCCCAGAT	0.433													0	0	0	1	0	66	197										A	21134339	G	A	21134339	3	1	82	1	0	0	0	0	1	0	0	0	14110	1291	45	1	741	1	SERPIND1	22	21134339	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08		21134339	30170227	450	24834										
SERPIND1	3053	broad.mit.edu	37	chr22	21134464	21134464	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gaccctgctacccagatgatGattctcaactgcatctactt	6	13	2	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:21134464G>A	uc002ztb.1	+	2	931	c.864G>A	c.(862-864)ATG>ATA	p.M288I	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.M316I	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	288					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CCCAGATGATGATTCTCAACT	0.423													0	0	0	1	0	70	217										A	21134464	G	A	21134464	3	1	82	1	0	0	0	0	1	0	0	0	14110	1290	45	1	866	1	SERPIND1	22	21134464	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	125	21134464	30170102	451	24835										
MN1	4330	broad.mit.edu	37	chr22	28193195	28193195	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gccgtagctgtcaggggtcgAggtagagttagacatgatgc	16	7	1	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:28193195A>C	uc003adj.2	-	1	4292	c.3337T>G	c.(3337-3339)TCG>GCG	p.S1113A		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1113							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						TCAGGGGTCGAGGTAGAGTTA	0.756			T	ETV6	AML|meningioma								0	0	0	1	0	6	16										C	28193195	A	C	28193195	3	2	82	1	0	0	0	0	1	0	0	0	9673	304	11	5	633	5	MN1	22	28193195	Missense_Mutation	SNP	A	TCGA-FD-A3SN-01A-12D-A22Z-08	7058731	28193195	23111371	452	24836										
KDELR3	11015	broad.mit.edu	37	chr22	38875600	38875600	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gtctctctccccttttaggtGgtttttctcctctgtgccta	7	13	4	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:38875600G>A	uc003avv.2	+	3	351	c.195G>A	c.(193-195)GTG>GTA	p.V65V	KDELR3_uc003avu.2_Silent_p.V65V	NM_006855	NP_006846	O43731	ERD23_HUMAN	KDEL receptor 3 isoform a	65	Helical; (Potential).				protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			ovary(2)	2	Melanoma(58;0.0286)					CCTTTTAGGTGGTTTTTCTCC	0.438													0	0	0	1	0	59	47										A	38875600	G	A	38875600	2	1	82	1	0	0	0	0	0	0	0	1	8121	1335	47	2		2	KDELR3	22	38875600	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	10682405	38875600	12428966	453	24837										
SREBF2	6721	broad.mit.edu	37	chr22	42271711	42271711	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	actctgagccaggaagccctCtattggatgatgcaaaggta	11	9	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:42271711C>G	uc003bbi.2	+	7	1538	c.1369C>G	c.(1369-1371)CTA>GTA	p.L457V	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|SREBF2_uc003bbj.2_RNA	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	457	Interaction with LMNA (By similarity).|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4						AGGAAGCCCTCTATTGGATGA	0.502													0	0	0	1	0	36	34										G	42271711	C	G	42271711	3	3	82	1	0	0	0	0	1	0	0	0	15141	912	32	1	1395	1	SREBF2	22	42271711	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	3396111	42271711	9032855	454	24838										
SEPT3	55964	broad.mit.edu	37	chr22	42392933	42392933	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	gcctcctgggcactgtccttCcacctgtgccagccaccccc	8	21	0	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chr22:42392933C>T	uc003bbr.3	+	11	1177	c.1039C>T	c.(1039-1041)CCA>TCA	p.P347S	WBP2NL_uc011ape.1_Intron|SEPT3_uc003bbs.3_3'UTR|SEPT3_uc010gyr.2_Missense_Mutation_p.P283S|SEPT3_uc011apj.1_3'UTR|SEPT3_uc010gys.2_Missense_Mutation_p.P127S|WBP2NL_uc003bbt.2_5'Flank|WBP2NL_uc011apk.1_5'Flank|WBP2NL_uc003bbu.2_5'Flank	NM_145733	NP_663786	Q9UH03	SEPT3_HUMAN	septin 3 isoform A	347					cell cycle|cytokinesis	cell junction|septin complex	GTP binding				0						CACTGTCCTTCCACCTGTGCC	0.577													0	0	0	1	0	46	30										T	42392933	C	T	42392933	3	4	82	1	0	0	0	0	1	0	0	0	14065	855	30	1	1123	1	SEPT3	22	42392933	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	121222	42392933	8911633	455	24839										
NHS	4810	broad.mit.edu	37	chrX	17746218	17746218	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atctcagtcagactcaccaaCtagagcaacagatgtaagca	7	11	3	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:17746218C>G	uc004cxx.2	+	6	4267	c.3929C>G	c.(3928-3930)ACT>AGT	p.T1310S	NHS_uc011mix.1_Missense_Mutation_p.T1331S|NHS_uc004cxy.2_Missense_Mutation_p.T1154S|NHS_uc004cxz.2_Missense_Mutation_p.T1133S|NHS_uc004cya.2_Missense_Mutation_p.T1033S	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1310						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GACTCACCAACTAGAGCAACA	0.443													0	0	0	1	0	49	20										G	17746218	C	G	17746218	3	3	82	1	0	0	0	0	1	0	0	0	10411	565	20	4	4056	4	NHS	23	17746218	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08		17746218	137524342	456	24840										
ZNF182	7569	broad.mit.edu	37	chrX	47842407	47842407	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	cattcttctacctccaacttGaggatgaggtttggtttggt	10	8	2	2			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:47842407G>A	uc004dir.2	-	6	577	c.231C>T	c.(229-231)CTC>CTT	p.L77L	ZNF182_uc004dis.2_Silent_p.L58L|ZNF182_uc004dit.2_Silent_p.L77L|ZNF182_uc011mlu.1_Silent_p.L58L	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CCTCCAACTTGAGGATGAGGT	0.463													0	0	0	1	0	26	4										A	47842407	G	A	47842407	2	1	82	1	0	0	0	0	0	0	0	1	17747	1277	45	1		1	ZNF182	23	47842407	Silent	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	30096189	47842407	107428153	457	24841										
DGKK	139189	broad.mit.edu	37	chrX	50213550	50213550	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	aagcctcggagagcagcggcGgagccggcggcggagccggt	20	12	0	1			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:50213550G>A	uc010njr.1	-	1	188	c.128C>T	c.(127-129)CCG>CTG	p.P43L		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	43					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					GAgcagcggcggagccggcgg	0.433													0	0	0	1	0	20	9										A	50213550	G	A	50213550	3	1	82	1	0	0	0	0	1	0	0	0	4472	1116	39	2	3798	2	DGKK	23	50213550	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	2371143	50213550	105057010	458	24842										
HTATSF1	27336	broad.mit.edu	37	chrX	135579901	135579901	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	atgagcagttgcgaatgcaaGaattgtacggagacggcaag	14	6	0	3			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:135579901G>A	uc004ezw.2	+	2	480	c.58G>A	c.(58-60)GAA>AAA	p.E20K	HTATSF1_uc004ezx.2_Missense_Mutation_p.E20K	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	20					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCGAATGCAAGAATTGTACGG	0.557													0	0	0	1	0	39	14										A	135579901	G	A	135579901	3	1	82	1	0	0	0	0	1	0	0	0	7433	943	33	1	60	1	HTATSF1	23	135579901	Missense_Mutation	SNP	G	TCGA-FD-A3SN-01A-12D-A22Z-08	85366351	135579901	19690659	459	24843										
FUNDC2	65991	broad.mit.edu	37	chrX	154282927	154282927	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.431372549019608	198	2.09807945065628e-62	3.61088534611511	4.59567225869195	3.40256503768539	1.49569550051364e-28	6.48134716889244e-27	143	ggggatttttcggaggctttCtgcttggcatggcatcctaa	13	8	1	0			TCGA-FD-A3SN-01A-12D-A22Z-08	TCGA-FD-A3SN-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b0a4d3f1-c0ac-4507-9e2a-7b86e8eb92ff	69161742-3ba9-43f9-b258-4ef2925b854d	g.chrX:154282927C>A	uc004fmw.2	+	5	700	c.550C>A	c.(550-552)CTG>ATG	p.L184M		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	184						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGAGGCTTTCTGCTTGGCAT	0.448													1	0	2.81731e-22	1	2.9685e-22	51	25										A	154282927	C	A	154282927	3	1	82	1	0	0	0	0	1	0	0	0	6098	912	32	3	568	3	FUNDC2	23	154282927	Missense_Mutation	SNP	C	TCGA-FD-A3SN-01A-12D-A22Z-08	18703026	154282927	987633	460	24844										
PLCH2	9651	broad.mit.edu	37	chr1	2419057	2419057	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tggactgctgggatgggcccGacggggagcccattgtgcac	17	11	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:2419057G>A	uc001aji.1	+	8	1409	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N	PLCH2_uc010nyz.1_Missense_Mutation_p.D167N|PLCH2_uc009vle.1_Missense_Mutation_p.D167N|PLCH2_uc001ajj.1_Missense_Mutation_p.D167N|PLCH2_uc001ajk.1_Missense_Mutation_p.D167N	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	379	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGATGGGCCCGACGGGGAGCC	0.567													0	0	0	1	0	4	25										A	2419057	G	A	2419057	3	1	83	1	0	0	0	0	1	0	0	0	12038	1058	37	1	1165	1	PLCH2	1	2419057	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		2419057	246831564	1	24845										
RHCE	6006	broad.mit.edu	37	chr1	25729193	25729193	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccttccccaagacagcacccGctgagatcagcaccgacata	7	17	1	2	rs1053346		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:25729193G>A	uc001bkf.2	-	3	466	c.380C>T	c.(379-381)GCG>GTG	p.A127V	RHCE_uc001bkg.2_Missense_Mutation_p.A127V|RHCE_uc001bkh.2_Missense_Mutation_p.A127V|RHCE_uc001bki.2_Missense_Mutation_p.A127V|RHCE_uc001bkj.2_Missense_Mutation_p.A111V	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	127	Helical; (Potential).					integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GACAGCACCCGCTGAGATCAG	0.537													0	0	0	1	0	23	31										A	25729193	G	A	25729193	3	1	83	1	0	0	0	0	1	0	0	0	13325	1087	38	2	905	2	RHCE	1	25729193	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	23310136	25729193	223521428	2	24846										
MACF1	23499	broad.mit.edu	37	chr1	39824382	39824382	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggcacagtgtacacgattagGatctcacctgaatatgctgt	10	9	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824382G>C	uc010oiu.1	+	10	7408	c.7277G>C	c.(7276-7278)GGA>GCA	p.G2426A	MACF1_uc010ois.1_Missense_Mutation_p.G1924A|MACF1_uc001cda.1_Missense_Mutation_p.G1832A|MACF1_uc001cdc.1_Missense_Mutation_p.G1011A|MACF1_uc001cdb.1_Missense_Mutation_p.G1011A	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3991					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACACGATTAGGATCTCACCTG	0.502													0	0	0	1	0	16	38										C	39824382	G	C	39824382	3	2	83	1	0	0	0	0	1	0	0	0	9144	1174	41	1	12084	1	MACF1	1	39824382	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	14095189	39824382	209426239	3	24847			1	112		3	3	504	G		2.424672e-05
MACF1	23499	broad.mit.edu	37	chr1	39824525	39824525	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgaccctggagttctccagGagcagcttgcaacaacaaag	10	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824525G>C	uc010oiu.1	+	10	7551	c.7420G>C	c.(7420-7422)GAG>CAG	p.E2474Q	MACF1_uc010ois.1_Missense_Mutation_p.E1972Q|MACF1_uc001cda.1_Missense_Mutation_p.E1880Q|MACF1_uc001cdc.1_Missense_Mutation_p.E1059Q|MACF1_uc001cdb.1_Missense_Mutation_p.E1059Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4039	Spectrin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGTTCTCCAGGAGCAGCTTGC	0.512													0	0	0	1	0	15	42										C	39824525	G	C	39824525	3	2	83	1	0	0	0	0	1	0	0	0	9144	1175	41	1	12227	1	MACF1	1	39824525	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	143	39824525	209426096	4	24848			1	112		3	3	504	G		2.424672e-05
MACF1	23499	broad.mit.edu	37	chr1	39824885	39824885	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagtagctcgtgacataatgGaaattgaaggggagccagcc	13	7	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824885G>A	uc010oiu.1	+	11	7644	c.7513G>A	c.(7513-7515)GAA>AAA	p.E2505K	MACF1_uc010ois.1_Missense_Mutation_p.E2003K|MACF1_uc001cda.1_Missense_Mutation_p.E1911K|MACF1_uc001cdc.1_Missense_Mutation_p.E1090K|MACF1_uc001cdb.1_Missense_Mutation_p.E1090K	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4070	Spectrin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGACATAATGGAAATTGAAGG	0.423													0	0	0	1	0	16	62										A	39824885	G	A	39824885	3	1	83	1	0	0	0	0	1	0	0	0	9144	1175	41	1	12324	1	MACF1	1	39824885	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	360	39824885	209425736	5	24849			1	112		3	3	504	G		2.424672e-05
ZMPSTE24	10269	broad.mit.edu	37	chr1	40737653	40737653	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaaagcttaaagaagaaattGaagtaatggcaaagagtatt	10	2	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:40737653G>A	uc001cfg.2	+	6	926	c.715G>A	c.(715-717)GAA>AAA	p.E239K		NM_005857	NP_005848	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	239						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity				0	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			AGAAGAAATTGAAGTAATGGC	0.373													0	0	0	1	0	18	90										A	40737653	G	A	40737653	3	1	83	1	0	0	0	0	1	0	0	0	17695	1291	45	1	737	1	ZMPSTE24	1	40737653	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	912768	40737653	208512968	6	24850										
IPO13	9670	broad.mit.edu	37	chr1	44424184	44424184	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgggcttcctgctgtcagctCttcaagtggaggagatcctt	12	10	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:44424184C>T	uc001ckx.2	+	10	2596	c.1801C>T	c.(1801-1803)CTT>TTT	p.L601F		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	601	HEAT 10.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCTGTCAGCTCTTCAAGTGGA	0.552													0	0	0	1	0	9	96										T	44424184	C	T	44424184	3	4	83	1	0	0	0	0	1	0	0	0	7794	913	32	1	1839	1	IPO13	1	44424184	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3686531	44424184	204826437	7	24851										
FOXD2	2306	broad.mit.edu	37	chr1	47904362	47904362	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctctctctcaacgactgcttCgtcaagatcccccgcgagcc	7	18	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:47904362C>G	uc001crm.2	+	1	2674	c.555C>G	c.(553-555)TTC>TTG	p.F185L		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	185	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		ACGACTGCTTCGTCAAGATCC	0.637													0	0	0	1	0	28	81										G	47904362	C	G	47904362	3	3	83	1	0	0	0	0	1	0	0	0	5997	883	31	1	557	1	FOXD2	1	47904362	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3480178	47904362	201346259	8	24852										
INADL	10207	broad.mit.edu	37	chr1	62263049	62263049	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tggtacacctaaccctagttCgaaggaagacatcctcatct	7	12	2	1	rs117405402	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:62263049C>T	uc001dab.2	+	11	1465	c.1351C>T	c.(1351-1353)CGA>TGA	p.R451*	INADL_uc009waf.1_Nonsense_Mutation_p.R451*|INADL_uc001daa.2_Nonsense_Mutation_p.R451*|INADL_uc001dad.3_Nonsense_Mutation_p.R148*	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	451	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AACCCTAGTTCGAAGGAAGAC	0.448													0	0	0	1	0	33	84										T	62263049	C	T	62263049	4	4	83	1	0	0	0	0	0	1	0	0	7731	876	31	1	1389	1	INADL	1	62263049	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	14358687	62263049	186987572	9	24853										
PDE4B	5142	broad.mit.edu	37	chr1	66834533	66834533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccaagtccttggaattgtatCggcaatggacagaccgcatc	10	11	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:66834533C>T	uc001dcn.2	+	16	1917	c.1726C>T	c.(1726-1728)CGG>TGG	p.R576W	PDE4B_uc009war.2_Missense_Mutation_p.R484W|PDE4B_uc001dco.2_Missense_Mutation_p.R576W|PDE4B_uc001dcp.2_Missense_Mutation_p.R561W|PDE4B_uc001dcq.2_Missense_Mutation_p.R404W|PDE4B_uc009was.2_Missense_Mutation_p.R343W	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	576					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GGAATTGTATCGGCAATGGAC	0.463													0	0	0	1	0	16	70										T	66834533	C	T	66834533	3	4	83	1	0	0	0	0	1	0	0	0	11640	875	31	1	2142	1	PDE4B	1	66834533	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4571484	66834533	182416088	10	24854										
SERBP1	26135	broad.mit.edu	37	chr1	67890585	67890585	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accaacgttaattcgtctttGacagttccccagttgtgaga	8	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:67890585G>A	uc001ddv.2	-	4	821	c.681C>T	c.(679-681)GTC>GTT	p.V227V	SERBP1_uc001ddx.2_Silent_p.V221V|SERBP1_uc001ddy.2_Silent_p.V221V|SERBP1_uc001ddw.2_Silent_p.V227V	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	227					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						ATTCGTCTTTGACAGTTCCCC	0.368													0	0	0	1	0	34	59										A	67890585	G	A	67890585	2	1	83	1	0	0	0	0	0	0	0	1	14075	1277	45	1		1	SERBP1	1	67890585	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1056052	67890585	181360036	11	24855										
LRRC7	57554	broad.mit.edu	37	chr1	70504079	70504079	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagacaggattgttggtgttCccctggaactcgagcagtct	12	9	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:70504079C>T	uc001dep.2	+	19	2488	c.2458C>T	c.(2458-2460)CCC>TCC	p.P820S	LRRC7_uc009wbg.2_Missense_Mutation_p.P104S|LRRC7_uc001deq.2_Missense_Mutation_p.P61S	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	820						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGTTGGTGTTCCCCTGGAACT	0.493													0	0	0	1	0	29	59										T	70504079	C	T	70504079	3	4	83	1	0	0	0	0	1	0	0	0	9020	855	30	1	2532	1	LRRC7	1	70504079	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2613494	70504079	178746542	12	24856										
GBP5	115362	broad.mit.edu	37	chr1	89735197	89735197	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agctgctcattaaagttctcGatgaggcacatggggtctga	12	8	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:89735197G>A	uc001dnc.2	-	3	579	c.42C>T	c.(40-42)ATC>ATT	p.I14I	GBP5_uc001dnd.2_Silent_p.I14I|GBP5_uc001dne.1_Silent_p.I14I	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	14						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		TAAAGTTCTCGATGAGGCACA	0.478													0	0	0	1	0	44	132										A	89735197	G	A	89735197	2	1	83	1	0	0	0	0	0	0	0	1	6277	1048	37	1		1	GBP5	1	89735197	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	19231118	89735197	159515424	13	24857										
BRDT	676	broad.mit.edu	37	chr1	92459724	92459724	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cacatgtaatgccaccaaatCaccaccaattagcatttaat	3	12	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:92459724C>T	uc001dok.3	+	15	2549	c.2200C>T	c.(2200-2202)CAC>TAC	p.H734Y	BRDT_uc001dol.3_Missense_Mutation_p.H734Y|BRDT_uc010osz.1_Missense_Mutation_p.H738Y|BRDT_uc009wdf.2_Missense_Mutation_p.H661Y|BRDT_uc010ota.1_Missense_Mutation_p.H688Y|BRDT_uc010otb.1_Missense_Mutation_p.H688Y|BRDT_uc001dom.3_Missense_Mutation_p.H734Y	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GCCACCAAATCACCACCAATT	0.363													0	0	0	1	0	18	83										T	92459724	C	T	92459724	3	4	83	1	0	0	0	0	1	0	0	0	1508	826	29	1	2254	1	BRDT	1	92459724	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2724527	92459724	156790897	14	24858										
DNTTIP2	30836	broad.mit.edu	37	chr1	94343201	94343201	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aaatggtatcatggtgctcaGacacagaataatttgactct	8	7	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:94343201G>A	uc001dqf.2	-	2	328	c.290C>T	c.(289-291)TCT>TTT	p.S97F	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Intron	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		ATGGTGCTCAGACACAGAATA	0.458													0	0	0	1	0	11	42										A	94343201	G	A	94343201	3	1	83	1	0	0	0	0	1	0	0	0	4682	942	33	1	2004	1	DNTTIP2	1	94343201	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1883477	94343201	154907420	15	24859										
AGL	178	broad.mit.edu	37	chr1	100358047	100358047	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	attgggttcagttcaactgtGtggagtaggaaaattccctt	11	6	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:100358047G>T	uc001dsi.1	+	24	3543	c.3143G>T	c.(3142-3144)TGT>TTT	p.C1048F	AGL_uc001dsj.1_Missense_Mutation_p.C1048F|AGL_uc001dsk.1_Missense_Mutation_p.C1048F|AGL_uc001dsl.1_Missense_Mutation_p.C1048F|AGL_uc001dsm.1_Missense_Mutation_p.C1032F|AGL_uc001dsn.1_Missense_Mutation_p.C1031F	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1048	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GTTCAACTGTGTGGAGTAGGA	0.368													1	0	2.32078e-09	1	2.41399e-09	15	40										T	100358047	G	T	100358047	3	4	83	1	0	0	0	0	1	0	0	0	384	1377	48	4	3302	4	AGL	1	100358047	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6014846	100358047	148892574	16	24860										
CCDC76	54482	broad.mit.edu	37	chr1	100614274	100614274	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tatttgcagcagaagggattCagtcctgctttgcagtacta	10	8	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:100614274C>T	uc001dsv.2	+	11	1363	c.1344C>T	c.(1342-1344)TTC>TTT	p.F448F	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_3'UTR	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	448					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		AGAAGGGATTCAGTCCTGCTT	0.383													0	0	0	1	0	16	63										T	100614274	C	T	100614274	2	4	83	1	0	0	0	0	0	0	0	1	2850	825	29	1		1	CCDC76	1	100614274	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	256227	100614274	148636347	17	24861										
EXTL2	2135	broad.mit.edu	37	chr1	101343047	101343047	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcaccattggtttccagttCaggaaagacctggagtcgat	10	10	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:101343047C>T	uc001dtk.1	-	3	755	c.418G>A	c.(418-420)GAA>AAA	p.E140K	EXTL2_uc001dtl.1_Missense_Mutation_p.E140K|EXTL2_uc010ouk.1_Missense_Mutation_p.E127K|EXTL2_uc001dtm.1_Missense_Mutation_p.E140K	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	140	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		GTTTCCAGTTCAGGAAAGACC	0.488													0	0	0	1	0	13	48										T	101343047	C	T	101343047	3	4	83	1	0	0	0	0	1	0	0	0	5326	835	29	1	586	1	EXTL2	1	101343047	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	728773	101343047	147907574	18	24862										
KCNA3	3738	broad.mit.edu	37	chr1	111216259	111216259	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agctcccgcatggacgccttCagcgtttgcccgaggatctg	12	14	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:111216259C>G	uc001dzv.1	-	1	1397	c.1173G>C	c.(1171-1173)CTG>CTC	p.L391L		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	391						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGACGCCTTCAGCGTTTGCC	0.587													0	0	0	1	0	28	83										G	111216259	C	G	111216259	2	3	83	1	0	0	0	0	0	0	0	1	8004	813	29	1		1	KCNA3	1	111216259	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	9873212	111216259	138034362	19	24863										
PTPN22	26191	broad.mit.edu	37	chr1	114380755	114380755	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttagaattagaacatccctCaaacaaaagagagcccaaat	5	9	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:114380755C>T	uc001eds.2	-	13	1397	c.1267G>A	c.(1267-1269)GAG>AAG	p.E423K	PTPN22_uc009wgq.2_Missense_Mutation_p.E368K|PTPN22_uc010owo.1_Missense_Mutation_p.E179K|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.E423K|PTPN22_uc009wgs.2_Missense_Mutation_p.E296K|PTPN22_uc001edu.2_Missense_Mutation_p.E423K	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	423					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACATCCCTCAAACAAAAGA	0.388													0	0	0	1	0	19	51										T	114380755	C	T	114380755	3	4	83	1	0	0	0	0	1	0	0	0	12787	835	29	1	1215	1	PTPN22	1	114380755	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3164496	114380755	134869866	20	24864										
HSD3B2	3284	broad.mit.edu	37	chr1	119962079	119962079	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agctgactgtacttgaaggaGacattctggatgagccattc	11	8	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:119962079G>C	uc001ehs.2	+	2	954	c.181G>C	c.(181-183)GAC>CAC	p.D61H	HSD3B2_uc001eht.2_Missense_Mutation_p.D61H|HSD3B2_uc001ehu.2_Missense_Mutation_p.D61H	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	61					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACTTGAAGGAGACATTCTGGA	0.493													0	0	0	1	0	11	35										C	119962079	G	C	119962079	3	2	83	1	0	0	0	0	1	0	0	0	7391	942	33	1	187	1	HSD3B2	1	119962079	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	5581324	119962079	129288542	21	24865										
HSD3B2	3284	broad.mit.edu	37	chr1	119965133	119965133	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acaagaaggctcagcgagatCtggcgtataagccactctac	10	11	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:119965133C>G	uc001ehs.2	+	3	1782	c.1009C>G	c.(1009-1011)CTG>GTG	p.L337V	HSD3B2_uc001eht.2_Missense_Mutation_p.L337V|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	337					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TCAGCGAGATCTGGCGTATAA	0.512													0	0	0	1	0	14	47										G	119965133	C	G	119965133	3	3	83	1	0	0	0	0	1	0	0	0	7391	912	32	1	1019	1	HSD3B2	1	119965133	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3054	119965133	129285488	22	24866										
HSD3B1	3283	broad.mit.edu	37	chr1	120056980	120056980	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgagcaaagagttcggcctCcgccttgattccagatggag	12	11	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:120056980C>T	uc001ehv.1	+	4	979	c.834C>T	c.(832-834)CTC>CTT	p.L278L	HSD3B1_uc001ehw.2_Silent_p.L280L	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	278					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	AGTTCGGCCTCCGCCTTGATT	0.473													0	0	0	1	0	8	152										T	120056980	C	T	120056980	2	4	83	1	0	0	0	0	0	0	0	1	7390	842	30	1		1	HSD3B1	1	120056980	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	91847	120056980	129193641	23	24867										
ADAM30	11085	broad.mit.edu	37	chr1	120438233	120438233	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtgtatcctcatacgaacatCttgaaagtaggtgtccataa	8	8	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:120438233C>T	uc001eij.2	-	1	881	c.727G>A	c.(727-729)GAT>AAT	p.D243N		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	243	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ATACGAACATCTTGAAAGTAG	0.368													0	0	0	1	0	23	70										T	120438233	C	T	120438233	3	4	83	1	0	0	0	0	1	0	0	0	248	913	32	1	1649	1	ADAM30	1	120438233	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	381253	120438233	128812388	24	24868										
PDE4DIP	9659	broad.mit.edu	37	chr1	144857639	144857639	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tctgttgattatgggcgtttCtgagccaggagtagaggaag	15	5	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:144857639C>G	uc001elw.3	-	39	6706	c.6415G>C	c.(6415-6417)GAA>CAA	p.E2139Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E2033Q|PDE4DIP_uc001elv.3_Missense_Mutation_p.E1146Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2139					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGGGCGTTTCTGAGCCAGGA	0.488			T	PDGFRB	MPD								0	0	0	1	0	12	254										G	144857639	C	G	144857639	3	3	83	1	0	0	0	0	1	0	0	0	11643	922	32	1	649	1	PDE4DIP	1	144857639	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	24419406	144857639	104392982	25	24869										
TXNIP	10628	broad.mit.edu	37	chr1	145439622	145439622	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agatggtgatcatgagacctGgaaacaaatatgagtacaag	11	5	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:145439622G>A	uc001enn.3	+	2	621	c.280G>A	c.(280-282)GGA>AGA	p.G94R	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.G39R	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	94					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATGAGACCTGGAAACAAATA	0.398													0	0	0	1	0	33	122										A	145439622	G	A	145439622	3	1	83	1	0	0	0	0	1	0	0	0	16800	1349	47	2	286	2	TXNIP	1	145439622	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	581983	145439622	103810999	26	24870										
ANKRD35	148741	broad.mit.edu	37	chr1	145567755	145567755	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccttagcatggaagaggagtGaggcagcctcactgtgtgcc	14	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:145567755G>A	uc001eob.1	+	13	3113	c.3005G>A	c.(3004-3006)TGA>TAA	p.*1002*	NBPF10_uc001emp.3_Intron	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	1002										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAAGAGGAGTGAGGCAGCCTC	0.478													0	0	0	1	0	39	117										A	145567755	G	A	145567755	2	1	83	1	0	0	0	0	0	0	0	1	664	1285	45	1		1	ANKRD35	1	145567755	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	128133	145567755	103682866	27	24871										
ECM1	1893	broad.mit.edu	37	chr1	150484937	150484937	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcgggatgagtgctttgcccGtcgggctccttaccccaact	11	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:150484937G>A	uc001eus.2	+	8	1392	c.1193G>A	c.(1192-1194)CGT>CAT	p.R398H	ECM1_uc001eut.2_Missense_Mutation_p.R273H|ECM1_uc001euu.2_Missense_Mutation_p.R427H|ECM1_uc001euv.2_Missense_Mutation_p.R425H|ECM1_uc009wlu.2_Missense_Mutation_p.R158H	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	398	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGCTTTGCCCGTCGGGCTCCT	0.567													0	0	0	1	0	23	104										A	150484937	G	A	150484937	3	1	83	1	0	0	0	0	1	0	0	0	4897	1145	40	2	1223	2	ECM1	1	150484937	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4917182	150484937	98765684	28	24872										
FAM63A	55793	broad.mit.edu	37	chr1	150972348	150972348	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggaatgtcaccttctgtcacGaggttggtgtcactggagtg	14	8	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:150972348G>A	uc001ewf.2	-	7	2512	c.828C>T	c.(826-828)CTC>CTT	p.L276L	FAM63A_uc001ewc.2_Silent_p.L134L|FAM63A_uc010pcm.1_Silent_p.L181L|FAM63A_uc001ewd.2_Silent_p.L134L|FAM63A_uc001ewe.2_Silent_p.L110L|FAM63A_uc010pcn.1_Silent_p.L324L|FAM63A_uc001ewg.2_Silent_p.L276L	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	276							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTTCTGTCACGAGGTTGGTGT	0.418													0	0	0	1	0	8	39										A	150972348	G	A	150972348	2	1	83	1	0	0	0	0	0	0	0	1	5596	1045	37	1		1	FAM63A	1	150972348	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	487411	150972348	98278273	29	24873										
MTX1	4580	broad.mit.edu	37	chr1	155181948	155181948	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgattatgatctgtcagctCggcaaggggcagacaccctg	12	11	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155181948C>T	uc001fjb.2	+	4	815	c.709C>T	c.(709-711)CGG>TGG	p.R237W	RAG1AP1_uc010pey.1_Intron|THBS3_uc001fja.2_5'Flank|THBS3_uc009wqj.1_5'Flank|MTX1_uc001fjc.2_Intron	NM_002455	NP_002446	Q13505	MTX1_HUMAN	metaxin 1 isoform 1	237					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			skin(1)	1	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCTGTCAGCTCGGCAAGGGGC	0.577													0	0	0	1	0	7	80										T	155181948	C	T	155181948	3	4	83	1	0	0	0	0	1	0	0	0	9967	875	31	1	723	1	MTX1	1	155181948	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4209600	155181948	94068673	30	24874										
ASH1L	55870	broad.mit.edu	37	chr1	155340407	155340407	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caggttcaggcagtagtggtCactgtgattatgatactgct	12	7	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155340407C>T	uc009wqq.2	-	12	7069	c.6589G>A	c.(6589-6591)GAC>AAC	p.D2197N	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2192N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2197	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAGTAGTGGTCACTGTGATTA	0.408													0	0	0	1	0	21	95										T	155340407	C	T	155340407	3	4	83	1	0	0	0	0	1	0	0	0	1041	826	29	1	2388	1	ASH1L	1	155340407	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	158459	155340407	93910214	31	24875										
MSTO1	55154	broad.mit.edu	37	chr1	155582954	155582954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccccactgtctgcatgtgggGagccttctggaacacgttgc	12	13	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155582954G>A	uc001fky.2	+	11	1246	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	MSTO1_uc001fkw.2_Missense_Mutation_p.E405K|MSTO1_uc001fkx.2_Missense_Mutation_p.E405K|MSTO1_uc001fla.2_Missense_Mutation_p.E224K|MSTO1_uc001fkz.2_Missense_Mutation_p.E336K|MSTO1_uc001fld.3_Missense_Mutation_p.E227K|MSTO1_uc009wqs.2_Missense_Mutation_p.E284K|MSTO1_uc010pgf.1_Missense_Mutation_p.E350K|MSTO1_uc001flb.2_Missense_Mutation_p.E274K|MSTO1_uc001flc.2_Missense_Mutation_p.E227K	NM_018116	NP_060586	Q9BUK6	MSTO1_HUMAN	misato	405					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex					0	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					TGCATGTGGGGAGCCTTCTGG	0.567													0	0	0	1	0	19	84										A	155582954	G	A	155582954	3	1	83	1	0	0	0	0	1	0	0	0	9894	1175	41	1	1255	1	MSTO1	1	155582954	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	242547	155582954	93667667	32	24876										
GON4L	54856	broad.mit.edu	37	chr1	155784175	155784175	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtcatctcagaagactgcctCaatctggatttctttgcccc	7	13	5	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155784175C>G	uc001flz.2	-	9	1324	c.1227G>C	c.(1225-1227)TTG>TTC	p.L409F	GON4L_uc001fly.1_Missense_Mutation_p.L409F|GON4L_uc009wrh.1_Missense_Mutation_p.L409F|GON4L_uc001fma.1_Missense_Mutation_p.L409F|GON4L_uc001fmc.2_Missense_Mutation_p.L409F|GON4L_uc001fmd.3_Missense_Mutation_p.L409F|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.L237F|GON4L_uc001fmf.2_Missense_Mutation_p.L103F	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	409					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAGACTGCCTCAATCTGGATT	0.393													0	0	0	1	0	24	107										G	155784175	C	G	155784175	3	3	83	1	0	0	0	0	1	0	0	0	6572	825	29	1	5708	1	GON4L	1	155784175	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	201221	155784175	93466446	33	24877										
ETV3	2117	broad.mit.edu	37	chr1	157105486	157105486	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctctgttttgtaggcccagtCaggaaactgataccctttca	8	11	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:157105486C>T	uc001fqr.2	-	3	350	c.61G>A	c.(61-63)GAC>AAC	p.D21N	ETV3_uc001fqt.2_Missense_Mutation_p.D21N	NM_001145312	NP_001138784	P41162	ETV3_HUMAN	ets variant gene 3 isoform 1	21							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(266;0.158)	Prostate(1639;0.174)				TAGGCCCAGTCAGGAAACTGA	0.507													0	0	0	1	0	26	79										T	157105486	C	T	157105486	3	4	83	1	0	0	0	0	1	0	0	0	5279	826	29	1	1521	1	ETV3	1	157105486	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1321311	157105486	92145135	34	24878										
SPTA1	6708	broad.mit.edu	37	chr1	158647509	158647509	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	catgacagcaagatttctctCaagtcccttgtgactgtgaa	8	10	2	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:158647509C>T	uc001fst.1	-	7	1127	c.928G>A	c.(928-930)GAG>AAG	p.E310K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	310	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGATTTCTCTCAAGTCCCTTG	0.453													0	0	0	1	0	12	39										T	158647509	C	T	158647509	3	4	83	1	0	0	0	0	1	0	0	0	15115	835	29	1	6515	1	SPTA1	1	158647509	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1542023	158647509	90603112	35	24879										
ATP1A2	477	broad.mit.edu	37	chr1	160097482	160097482	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccagctgatcacaggggtcGctgtattcctgggggtctcc	13	12	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:160097482G>A	uc001fvc.2	+	8	1021	c.889G>A	c.(889-891)GCT>ACT	p.A297T	ATP1A2_uc001fvb.2_Missense_Mutation_p.A297T|ATP1A2_uc010piz.1_Missense_Mutation_p.A142T|ATP1A2_uc001fvd.2_Missense_Mutation_p.A33T|ATP1A2_uc009wtg.1_5'Flank	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	297	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CACAGGGGTCGCTGTATTCCT	0.577													0	0	0	1	0	36	141										A	160097482	G	A	160097482	3	1	83	1	0	0	0	0	1	0	0	0	1129	1087	38	2	919	2	ATP1A2	1	160097482	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1449973	160097482	89153139	36	24880										
ADCY10	55811	broad.mit.edu	37	chr1	167798547	167798547	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agtgcagtattcatttgcatCataactgccaggtgggcata	10	8	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:167798547C>T	uc001ger.2	-	26	4006	c.3708G>A	c.(3706-3708)ATG>ATA	p.M1236I	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.M1144I|ADCY10_uc010plj.1_Missense_Mutation_p.M1083I	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1236					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TCATTTGCATCATAACTGCCA	0.413													0	0	0	1	0	26	89										T	167798547	C	T	167798547	3	4	83	1	0	0	0	0	1	0	0	0	293	826	29	1	1156	1	ADCY10	1	167798547	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7701065	167798547	81452074	37	24881										
FMO3	2328	broad.mit.edu	37	chr1	171083364	171083364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcatcaaaagcagaaacaatGagatcattttatttaaagga	6	5	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:171083364G>A	uc001ghi.2	+	7	1156	c.1045G>A	c.(1045-1047)GAG>AAG	p.E349K	FMO3_uc001ghh.2_Missense_Mutation_p.E349K|FMO3_uc010pmb.1_Missense_Mutation_p.E329K|FMO3_uc010pmc.1_Missense_Mutation_p.E286K	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	349					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGAAACAATGAGATCATTTT	0.428													0	0	0	1	0	26	59										A	171083364	G	A	171083364	3	1	83	1	0	0	0	0	1	0	0	0	5956	1291	45	1	1067	1	FMO3	1	171083364	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3284817	171083364	78167257	38	24882										
PRDX6	9588	broad.mit.edu	37	chr1	173455466	173455466	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctaccactggcaggaactttGatgagattctcagggtagtc	11	9	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:173455466G>A	uc001giy.1	+	4	523	c.472G>A	c.(472-474)GAT>AAT	p.D158N		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	158	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						CAGGAACTTTGATGAGATTCT	0.443													0	0	0	1	0	55	181										A	173455466	G	A	173455466	3	1	83	1	0	0	0	0	1	0	0	0	12469	1290	45	1	486	1	PRDX6	1	173455466	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2372102	173455466	75795155	39	24883										
RC3H1	149041	broad.mit.edu	37	chr1	173952637	173952637	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgaggattctggtgctggaGaatgagctctgtaactgttc	13	7	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:173952637G>C	uc001gju.3	-	3	598	c.511C>G	c.(511-513)CTC>GTC	p.L171V	RC3H1_uc010pms.1_Missense_Mutation_p.L171V|RC3H1_uc001gjv.2_Missense_Mutation_p.L171V|RC3H1_uc010pmt.1_Missense_Mutation_p.L171V	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	171					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGGTGCTGGAGAATGAGCTCT	0.483													0	0	0	1	0	20	85										C	173952637	G	C	173952637	3	2	83	1	0	0	0	0	1	0	0	0	13166	942	33	1	2958	1	RC3H1	1	173952637	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	497171	173952637	75297984	40	24884										
ASTN1	460	broad.mit.edu	37	chr1	176833621	176833621	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agtccattgcaccaactgctGaggtccccaagctgggaaag	11	12	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:176833621G>C	uc001glc.2	-	23	3896	c.3684C>G	c.(3682-3684)CTC>CTG	p.L1228L	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1236					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						ACCAACTGCTGAGGTCCCCAA	0.522													0	0	0	1	0	15	52										C	176833621	G	C	176833621	2	2	83	1	0	0	0	0	0	0	0	1	1064	1277	45	1		1	ASTN1	1	176833621	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2880984	176833621	72417000	41	24885										
ARPC5	10092	broad.mit.edu	37	chr1	183599601	183599601	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taattcataacttaccttttCatgccattgcagtaacatag	4	9	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183599601C>T	uc001gql.2	-	3	579	c.388G>A	c.(388-390)GAA>AAA	p.E130K		NM_005717	NP_005708	O15511	ARPC5_HUMAN	actin related protein 2/3 complex subunit 5	130					actin cytoskeleton organization|cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|structural constituent of cytoskeleton				0						CTTACCTTTTCATGCCATTGC	0.348													0	0	0	1	0	12	53										T	183599601	C	T	183599601	3	4	83	1	0	0	0	0	1	0	0	0	974	835	29	1	75	1	ARPC5	1	183599601	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6765980	183599601	65651020	42	24886										
RGL1	23179	broad.mit.edu	37	chr1	183853908	183853908	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcctgggctgcatttggtctCgaagggataagaaggaaaac	14	7	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183853908C>T	uc001gqo.2	+	7	944	c.787C>T	c.(787-789)CGA>TGA	p.R263*	RGL1_uc010pof.1_Nonsense_Mutation_p.R68*|RGL1_uc001gqm.2_Nonsense_Mutation_p.R298*|RGL1_uc010pog.1_Nonsense_Mutation_p.R261*|RGL1_uc010poh.1_Nonsense_Mutation_p.R261*|RGL1_uc010poi.1_Nonsense_Mutation_p.R263*	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	263	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CATTTGGTCTCGAAGGGATAA	0.458													0	0	0	1	0	22	68										T	183853908	C	T	183853908	4	4	83	1	0	0	0	0	0	1	0	0	13276	876	31	1	918	1	RGL1	1	183853908	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	254307	183853908	65396713	43	24887										
GLT25D2	23127	broad.mit.edu	37	chr1	183920242	183920242	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgcgtttgaggtttatcatGaaaatctaatgcaagaagga	10	5	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183920242G>A	uc001gqr.2	-	8	1407	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F	GLT25D2_uc010poj.1_Silent_p.F345F|GLT25D2_uc001gqq.2_Silent_p.F82F|GLT25D2_uc001gqs.2_Silent_p.F225F	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	345					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						GGTTTATCATGAAAATCTAAT	0.403													0	0	0	1	0	72	109										A	183920242	G	A	183920242	2	1	83	1	0	0	0	0	0	0	0	1	6467	1281	45	1		1	GLT25D2	1	183920242	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	66334	183920242	65330379	44	24888										
PRG4	10216	broad.mit.edu	37	chr1	186281364	186281364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtacagaagtgccctggaaGaaggcctgctctaaattatc	10	9	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:186281364G>A	uc001gru.3	+	11	3902	c.3851G>A	c.(3850-3852)AGA>AAA	p.R1284K	PRG4_uc001grt.3_Missense_Mutation_p.R1243K|PRG4_uc009wyl.2_Missense_Mutation_p.R1191K|PRG4_uc009wym.2_Missense_Mutation_p.R1150K|PRG4_uc010poo.1_RNA|TPR_uc001grv.2_3'UTR	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1284					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						TGCCCTGGAAGAAGGCCTGCT	0.403													0	0	0	1	0	57	71										A	186281364	G	A	186281364	3	1	83	1	0	0	0	0	1	0	0	0	12481	942	33	1	3889	1	PRG4	1	186281364	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2361122	186281364	62969257	45	24889										
TPR	7175	broad.mit.edu	37	chr1	186313156	186313156	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtcacttaatttttcgatctGatcatgaagtaatctgtttt	6	6	4	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:186313156G>C	uc001grv.2	-	26	3781	c.3484C>G	c.(3484-3486)CAG>GAG	p.Q1162E		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1162	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTTCGATCTGATCATGAAGT	0.393			T	NTRK1	papillary thyroid								0	0	0	1	0	10	48										C	186313156	G	C	186313156	3	2	83	1	0	0	0	0	1	0	0	0	16413	1299	45	1	3711	1	TPR	1	186313156	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	31792	186313156	62937465	46	24890										
KCNT2	343450	broad.mit.edu	37	chr1	196397285	196397285	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taaaaaatccataagtaaatCaatcttcagtgagctgacac	5	8	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:196397285C>G	uc001gtd.1	-	10	994	c.934G>C	c.(934-936)GAT>CAT	p.D312H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.D312H|KCNT2_uc001gtf.1_Missense_Mutation_p.D312H|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.D312H|KCNT2_uc009wyv.1_Missense_Mutation_p.D287H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	312	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATAAGTAAATCAATCTTCAGT	0.373													0	0	0	1	0	20	72										G	196397285	C	G	196397285	3	3	83	1	0	0	0	0	1	0	0	0	8092	826	29	1	2549	1	KCNT2	1	196397285	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10084129	196397285	52853336	47	24891										
CFHR2	3080	broad.mit.edu	37	chr1	196928035	196928035	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgtgtaatatcacaagaaaTtatggaaaaatataacataa	5	3	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:196928035T>C	uc001gtq.1	+	5	715	c.638T>C	c.(637-639)ATT>ACT	p.I213T	CFHR2_uc001gtr.1_Missense_Mutation_p.I89T	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	213	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						TCACAAGAAATTATGGAAAAA	0.274													0	0	0	1	0	8	31										C	196928035	T	C	196928035	3	2	83	1	0	0	0	0	1	0	0	0	3285	1493	52	5	656	5	CFHR2	1	196928035	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	530750	196928035	52322586	48	24892										
CHIT1	1118	broad.mit.edu	37	chr1	203191375	203191375	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctctcttcttgcctcttgtaGagggggctgttatgtcccgt	11	11	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:203191375G>C	uc001gzn.2	-	7	780	c.684C>G	c.(682-684)CTC>CTG	p.L228L	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_Silent_p.L19L|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Silent_p.L219L	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	228					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						GCCTCTTGTAGAGGGGGCTGT	0.577													0	0	0	1	0	19	54										C	203191375	G	C	203191375	2	2	83	1	0	0	0	0	0	0	0	1	3346	929	33	1		1	CHIT1	1	203191375	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6263340	203191375	46059246	49	24893										
ATP2B4	493	broad.mit.edu	37	chr1	203693083	203693083	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tctcagtggctgtggtgtctCttcattgggattggagaact	13	7	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:203693083C>T	uc001gzw.2	+	19	3983	c.3099C>T	c.(3097-3099)CTC>CTT	p.L1033L	ATP2B4_uc001gzv.2_Silent_p.L1033L|ATP2B4_uc009xaq.2_Silent_p.L1033L|ATP2B4_uc001gzx.2_Silent_p.L64L|ATP2B4_uc009xar.2_Intron	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1033	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTGGTGTCTCTTCATTGGGA	0.532													0	0	0	1	0	24	100										T	203693083	C	T	203693083	2	4	83	1	0	0	0	0	0	0	0	1	1142	900	32	1		1	ATP2B4	1	203693083	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	501708	203693083	45557538	50	24894										
TLR5	7100	broad.mit.edu	37	chr1	223285449	223285449	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cttcaaatccttgagtgtctCaaagactcgtgagttcaggg	10	9	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:223285449C>T	uc001hnv.1	-	4	1371	c.925G>A	c.(925-927)GAG>AAG	p.E309K	TLR5_uc001hnw.1_Missense_Mutation_p.E309K	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	309	Extracellular (Potential).|LRR 5.				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		TTGAGTGTCTCAAAGACTCGT	0.443													0	0	0	1	0	51	62										T	223285449	C	T	223285449	3	4	83	1	0	0	0	0	1	0	0	0	15951	835	29	1	1655	1	TLR5	1	223285449	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	19592366	223285449	25965172	51	24895										
PARP1	142	broad.mit.edu	37	chr1	226566910	226566910	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggttcctttaacgatgtccaCcaggccaagggtggcactga	12	11	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:226566910C>G	uc001hqd.3	-	12	1849	c.1678G>C	c.(1678-1680)GTG>CTG	p.V560L		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	560					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		ACGATGTCCACCAGGCCAAGG	0.527								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	1	0	59	109										G	226566910	C	G	226566910	3	3	83	1	0	0	0	0	1	0	0	0	11454	507	18	4	1414	4	PARP1	1	226566910	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3281461	226566910	22683711	52	24896										
ACTN2	88	broad.mit.edu	37	chr1	236908074	236908074	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcagccatcgcgcaggagctCaagtatgtgcagatgccctc	12	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:236908074C>G	uc001hyf.2	+	12	1608	c.1404C>G	c.(1402-1404)CTC>CTG	p.L468L	ACTN2_uc001hyg.2_Silent_p.L260L|ACTN2_uc009xgi.1_Silent_p.L468L|ACTN2_uc010pxu.1_Silent_p.L157L|ACTN2_uc001hyh.2_Silent_p.L156L	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	468	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGCAGGAGCTCAAGTATGTGC	0.647													0	0	0	1	0	12	48										G	236908074	C	G	236908074	2	3	83	1	0	0	0	0	0	0	0	1	205	813	29	1		1	ACTN2	1	236908074	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10341164	236908074	12342547	53	24897										
OR1C1	26188	broad.mit.edu	37	chr1	247920938	247920938	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gatgaagggctgaaatagacGgcgatggctgtgccgtaaaa	15	6	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:247920938G>A	uc010pza.1	-	1	771	c.771C>T	c.(769-771)GCC>GCT	p.A257A		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAAATAGACGGCGATGGCTG	0.512													0	0	0	1	0	25	53										A	247920938	G	A	247920938	2	1	83	1	0	0	0	0	0	0	0	1	10952	1103	39	2		2	OR1C1	1	247920938	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	11012864	247920938	1329683	54	24898										
OR2M5	127059	broad.mit.edu	37	chr1	248308805	248308805	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctttctgttggctgttatgtCttatgaccgctatattgcca	8	9	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:248308805C>G	uc010pze.1	+	1	356	c.356C>G	c.(355-357)TCT>TGT	p.S119C		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GCTGTTATGTCTTATGACCGC	0.453													0	0	0	1	0	116	354										G	248308805	C	G	248308805	3	3	83	1	0	0	0	0	1	0	0	0	11013	913	32	1	358	1	OR2M5	1	248308805	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	387867	248308805	941816	55	24899										
TPO	7173	broad.mit.edu	37	chr2	1460027	1460027	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gactgccagatgacttgtgaGaaccaaaacccatgttttcc	8	11	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:1460027G>A	uc002qww.2	+	7	883	c.792G>A	c.(790-792)GAG>GAA	p.E264E	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Silent_p.E264E|TPO_uc002qwr.2_Silent_p.E264E|TPO_uc002qwx.2_Silent_p.E264E|TPO_uc010yio.1_Silent_p.E264E|TPO_uc010yip.1_Silent_p.E264E	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	264	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGACTTGTGAGAACCAAAACC	0.443													0	0	0	1	0	8	30										A	1460027	G	A	1460027	2	1	83	1	0	0	0	0	0	0	0	1	16407	933	33	1		1	TPO	2	1460027	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		1460027	241739346	56	24900										
HADHA	3030	broad.mit.edu	37	chr2	26424095	26424095	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aatcaccatgtcggccttttCaaaaccttggtaatcaagct	6	11	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:26424095C>G	uc002rgy.2	-	13	1445	c.1315G>C	c.(1315-1317)GAA>CAA	p.E439Q	HADHA_uc010yks.1_Missense_Mutation_p.E352Q	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	439					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TCGGCCTTTTCAAAACCTTGG	0.423													0	0	0	1	0	16	39										G	26424095	C	G	26424095	3	3	83	1	0	0	0	0	1	0	0	0	6943	835	29	1	1008	1	HADHA	2	26424095	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	24964068	26424095	216775278	57	24901										
HADHB	3032	broad.mit.edu	37	chr2	26486347	26486347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atttttgctgtctggcacttCgtaagtatgacatgatcata	8	7	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:26486347C>T	uc002rgz.2	+	4	460	c.209C>T	c.(208-210)TCA>TTA	p.S70L	HADHB_uc010yku.1_RNA|HADHB_uc010ykv.1_Missense_Mutation_p.S48L|HADHB_uc010ykw.1_Missense_Mutation_p.S70L|HADHB_uc002rha.2_Missense_Mutation_p.S70L	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	70					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGCACTTCGTAAGTATGA	0.378													0	0	0	1	0	16	57										T	26486347	C	T	26486347	3	4	83	1	0	0	0	0	1	0	0	0	6944	898	31	1	219	1	HADHB	2	26486347	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	62252	26486347	216713026	58	24902										
LBH	81606	broad.mit.edu	37	chr2	30457350	30457350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggagatcggcctcagccccCgcaaggatggcctttcctac	11	15	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:30457350C>T	uc002rne.2	+	2	314	c.106C>T	c.(106-108)CGC>TGC	p.R36C		NM_030915	NP_112177	Q53QV2	LBH_HUMAN	limb bud and heart development homolog	36					multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus					0	Acute lymphoblastic leukemia(172;0.155)					CCTCAGCCCCCGCAAGGATGG	0.498													0	0	0	1	0	16	52										T	30457350	C	T	30457350	3	4	83	1	0	0	0	0	1	0	0	0	8650	652	23	2	112	2	LBH	2	30457350	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3971003	30457350	212742023	59	24903										
PRKD3	23683	broad.mit.edu	37	chr2	37513430	37513430	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgtgtgtggaactttcactCtgcacattaccatcttttcc	6	11	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513430C>G	uc002rqd.2	-	5	1355	c.800G>C	c.(799-801)AGA>ACA	p.R267T	PRKD3_uc002rqf.1_Missense_Mutation_p.R267T	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	267					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AACTTTCACTCTGCACATTAC	0.448													0	0	0	1	0	18	47										G	37513430	C	G	37513430	3	3	83	1	0	0	0	0	1	0	0	0	12520	913	32	1	1928	1	PRKD3	2	37513430	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7056080	37513430	205685943	60	24904			2	113		3	3	55	N	C	2.759663e-07
PRKD3	23683	broad.mit.edu	37	chr2	37513444	37513444	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttcactctgcacattaccatCttttccatccagattgggcg	6	13	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513444C>A	uc002rqd.2	-	5	1341	c.786G>T	c.(784-786)AAG>AAT	p.K262N	PRKD3_uc002rqf.1_Missense_Mutation_p.K262N	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	262					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				ACATTACCATCTTTTCCATCC	0.433													1	0	1.15088e-07	1	1.1852e-07	14	53										A	37513444	C	A	37513444	3	1	83	1	0	0	0	0	1	0	0	0	12520	912	32	3	1942	3	PRKD3	2	37513444	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	14	37513444	205685929	61	24905			2	113		3	3	55	N	C	2.759663e-07
PRKD3	23683	broad.mit.edu	37	chr2	37513484	37513484	+	Frame_Shift_Del	DEL	C	C	-													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaccactccaagaaggaattCtcttacttggttcctggtgg							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513484delC	uc002rqd.2	-	5	1301	c.746delG	c.(745-747)AGAfs	p.R249fs	PRKD3_uc002rqf.1_Frame_Shift_Del_p.R249fs	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	249					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AGAAGGAATTCTCTTACTTGG	0.418																		15	52	---	---								-	37513484	C	-	37513484	7	5	83	1	0	1	0	1	0	0	0	0	12520	913	32	0	1982	0	PRKD3	2	37513484	Frame_Shift_Del	DEL	C	TCGA-FD-A3SO-01A-11D-A22Z-08	40	37513484	205685889	62	24906			2	113		3	3	55	N	C	2.759663e-07
LRPPRC	10128	broad.mit.edu	37	chr2	44170868	44170868	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgggaaacttatgttggtgGatggttctgctaaccctaga	12	6	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:44170868G>A	uc002rtr.2	-	23	2520	c.2462C>T	c.(2461-2463)TCC>TTC	p.S821F	LRPPRC_uc010yob.1_Missense_Mutation_p.S721F	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	821	PPR 13.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TATGTTGGTGGATGGTTCTGC	0.358													0	0	0	1	0	32	108										A	44170868	G	A	44170868	3	1	83	1	0	0	0	0	1	0	0	0	8965	1174	41	1	1786	1	LRPPRC	2	44170868	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6657384	44170868	199028505	63	24907										
USP34	9736	broad.mit.edu	37	chr2	61622361	61622361	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atatgttactttcttgagttGatatatcctaattaaaaaaa	4	4	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:61622361G>A	uc002sbe.2	-	4	582	c.560C>T	c.(559-561)TCA>TTA	p.S187L		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	187					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TTCTTGAGTTGATATATCCTA	0.234													0	0	0	1	0	13	21										A	61622361	G	A	61622361	3	1	83	1	0	0	0	0	1	0	0	0	17062	1294	45	1	10388	1	USP34	2	61622361	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	17451493	61622361	181577012	64	24908										
C2orf86	51057	broad.mit.edu	37	chr2	63349172	63349172	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caaagtgaatcattttgagaGaaccaccatctctgatttcc	6	10	2	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:63349172G>A	uc002sch.2	-	18	2656	c.2210C>T	c.(2209-2211)TCT>TTT	p.S737F	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.S578F|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.S545F	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	737					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						CATTTTGAGAGAACCACCATC	0.279													0	0	0	1	0	15	59										A	63349172	G	A	63349172	3	1	83	1	0	0	0	0	1	0	0	0	2201	942	33	1	34	1	C2orf86	2	63349172	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1726811	63349172	179850201	65	24909										
ATP6V1B1	525	broad.mit.edu	37	chr2	71189911	71189911	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctggctacacctccaggatcGagcggatcatcaccccgcgc	10	17	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:71189911G>A	uc002shj.2	+	9	877	c.790G>A	c.(790-792)GAG>AAG	p.E264K	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.E264K|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.E222K	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	264					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CTCCAGGATCGAGCGGATCAT	0.582													0	0	0	1	0	10	59										A	71189911	G	A	71189911	3	1	83	1	0	0	0	0	1	0	0	0	1178	1059	37	1	824	1	ATP6V1B1	2	71189911	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	7840739	71189911	172009462	66	24910										
LBX2	85474	broad.mit.edu	37	chr2	74725261	74725261	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgccggttctggaaccaagtGaccacctgcgcgttggccag	13	14	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:74725261G>A	uc002slv.3	-	2	395	c.390C>T	c.(388-390)GTC>GTT	p.V130V	LBX2_uc002slw.2_Silent_p.V126V	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	130	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGAACCAAGTGACCACCTGCG	0.667													0	0	0	1	0	15	34										A	74725261	G	A	74725261	2	1	83	1	0	0	0	0	0	0	0	1	8654	1277	45	1		1	LBX2	2	74725261	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3535350	74725261	168474112	67	24911										
SFTPB	6439	broad.mit.edu	37	chr2	85893860	85893860	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgctccaggaacttcctcatCgtgtcctgggaggccagagg	13	12	1	1	rs45478492		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:85893860C>T	uc002sqh.2	-	4	279	c.273G>A	c.(271-273)ACG>ACA	p.T91T	SFTPB_uc002sqi.2_Silent_p.T103T|SFTPB_uc002sqj.2_Silent_p.T91T	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	91	Saposin B-type 1.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						ACTTCCTCATCGTGTCCTGGG	0.632													0	0	0	1	0	43	103										T	85893860	C	T	85893860	2	4	83	1	0	0	0	0	0	0	0	1	14191	871	31	1		1	SFTPB	2	85893860	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	11168599	85893860	157305513	68	24912										
FER1L5	90342	broad.mit.edu	37	chr2	97365429	97365429	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcctatctggctttggagctCattgtgggctctccaaatcc	9	12	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:97365429C>T	uc010fia.2	+	42	4834	c.4834C>T	c.(4834-4836)CAT>TAT	p.H1612Y	FER1L5_uc002sws.3_Missense_Mutation_p.H330Y|FER1L5_uc002swt.3_Missense_Mutation_p.H330Y|FER1L5_uc010yus.1_Missense_Mutation_p.H329Y	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1612						integral to membrane				ovary(1)	1						CTTTGGAGCTCATTGTGGGCT	0.527													0	0	0	1	0	38	80										T	97365429	C	T	97365429	3	4	83	1	0	0	0	0	1	0	0	0	5814	826	29	1	5000	1	FER1L5	2	97365429	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	11471569	97365429	145833944	69	24913										
TMEM131	23505	broad.mit.edu	37	chr2	98382950	98382950	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gatgacaataccttttgtttTctgggcatttcgtgatttgg	10	6	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:98382950T>C	uc002syh.3	-	34	4793	c.4564A>G	c.(4564-4566)AAA>GAA	p.K1522E		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1522						integral to membrane				ovary(4)|central_nervous_system(2)	6						CCTTTTGTTTTCTGGGCATTT	0.393													0	0	0	1	0	15	46										C	98382950	T	C	98382950	3	2	83	1	0	0	0	0	1	0	0	0	16041	1792	62	5	1119	5	TMEM131	2	98382950	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	1017521	98382950	144816423	70	24914										
TBC1D8	11138	broad.mit.edu	37	chr2	101656805	101656805	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccttcctcggcaacctgaaGaaagcccggaagaactcatt	8	13	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:101656805G>A	uc010fiv.2	-	6	1001	c.870C>T	c.(868-870)TTC>TTT	p.F290F	TBC1D8_uc010yvw.1_Silent_p.F305F|TBC1D8_uc002tau.3_Silent_p.F47F	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	290	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						GCAACCTGAAGAAAGCCCGGA	0.572													0	0	0	1	0	6	16										A	101656805	G	A	101656805	2	1	83	1	0	0	0	0	0	0	0	1	15622	933	33	1		1	TBC1D8	2	101656805	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3273855	101656805	141542568	71	24915										
RGPD4	285190	broad.mit.edu	37	chr2	108496500	108496500	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccaccacaaaaagtgcagaTcacttaaacggcctgcttcg	7	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:108496500T>A	uc010ywk.1	+	21	5083	c.5001T>A	c.(4999-5001)GAT>GAA	p.D1667E	RGPD4_uc002tdu.2_Missense_Mutation_p.D854E|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1667					intracellular transport		binding			skin(2)	2						AAAGTGCAGATCACTTAAACG	0.453													0	0	0	1	0	35	123										A	108496500	T	A	108496500	3	1	83	1	0	0	0	0	1	0	0	0	13288	1432	50	5	5083	5	RGPD4	2	108496500	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	6839695	108496500	134702873	72	24916										
IL1F6	27179	broad.mit.edu	37	chr2	113763586	113763586	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cacctcagcaggggagcattCaggatatcaatcatcgggtg	12	10	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:113763586C>A	uc010yxr.1	+	2	46	c.46C>A	c.(46-48)CAG>AAG	p.Q16K		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	16					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						GGGGAGCATTCAGGATATCAA	0.468													1	0	3.69857e-22	1	3.90991e-22	29	45										A	113763586	C	A	113763586	3	1	83	1	0	0	0	0	1	0	0	0	7654	827	29	3	52	3	IL1F6	2	113763586	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	5267086	113763586	129435787	73	24917										
EPB41L5	57669	broad.mit.edu	37	chr2	120844814	120844814	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tggttgtagaagatgatgatCaggtaggaataaaattatat	11	1	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:120844814C>G	uc002tmg.2	+	11	997	c.871C>G	c.(871-873)CAG>GAG	p.Q291E	EPB41L5_uc010flk.2_Missense_Mutation_p.Q291E|EPB41L5_uc010fll.2_Missense_Mutation_p.Q291E|EPB41L5_uc002tmh.3_Missense_Mutation_p.Q291E|EPB41L5_uc010flm.2_Missense_Mutation_p.Q95E	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	291	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AGATGATGATCAGGTAGGAAT	0.294													0	0	0	1	0	9	50										G	120844814	C	G	120844814	3	3	83	1	0	0	0	0	1	0	0	0	5157	827	29	1	909	1	EPB41L5	2	120844814	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7081228	120844814	122354559	74	24918										
FAM123C	205147	broad.mit.edu	37	chr2	131521644	131521644	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caggtcacggaggtgacactCtggatgcagagcccatgctg	14	11	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:131521644C>G	uc002trw.2	+	2	2189	c.1999C>G	c.(1999-2001)CTG>GTG	p.L667V	FAM123C_uc010fmv.2_Missense_Mutation_p.L667V|FAM123C_uc010fms.1_Missense_Mutation_p.L667V|FAM123C_uc010fmt.1_Missense_Mutation_p.L667V|FAM123C_uc010fmu.1_Missense_Mutation_p.L667V	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	667										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGTGACACTCTGGATGCAGA	0.652													0	0	0	1	0	8	17										G	131521644	C	G	131521644	3	3	83	1	0	0	0	0	1	0	0	0	5424	912	32	1	2001	1	FAM123C	2	131521644	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10676830	131521644	111677729	75	24919										
LRP1B	53353	broad.mit.edu	37	chr2	141816461	141816461	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttcccacttacctgttggttGagttcttttttgataaattc	6	8	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:141816461G>C	uc002tvj.1	-	9	2371	c.1399C>G	c.(1399-1401)CAA>GAA	p.Q467E	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	467	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTGTTGGTTGAGTTCTTTTT	0.358										TSP Lung(27;0.18)			0	0	0	1	0	10	42										C	141816461	G	C	141816461	3	2	83	1	0	0	0	0	1	0	0	0	8955	1299	45	1	12732	1	LRP1B	2	141816461	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10294817	141816461	101382912	76	24920										
ARL6IP6	151188	broad.mit.edu	37	chr2	153591519	153591519	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cctgttaaggattctggactCtacttataatatccctaact	5	10	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:153591519C>G	uc002tyn.2	+	3	1182	c.466C>G	c.(466-468)CTA>GTA	p.L156V	ARL6IP6_uc002tym.2_RNA|ARL6IP6_uc002tyo.2_Missense_Mutation_p.L48V	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	156	Helical; (Potential).					integral to membrane					0						ATTCTGGACTCTACTTATAAT	0.363													0	0	0	1	0	25	87										G	153591519	C	G	153591519	3	3	83	1	0	0	0	0	1	0	0	0	945	912	32	1	476	1	ARL6IP6	2	153591519	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	11775058	153591519	89607854	77	24921										
CCDC148	130940	broad.mit.edu	37	chr2	159195330	159195330	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcactgagaattgaagatttCaaatcagggtatgggcattc	10	6	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:159195330C>G	uc002tzq.2	-	7	935	c.672G>C	c.(670-672)TTG>TTC	p.L224F	CCDC148_uc002tzr.2_Missense_Mutation_p.L72F|CCDC148_uc010foh.2_Intron|CCDC148_uc010foi.1_Missense_Mutation_p.L171F|CCDC148_uc010foj.1_Missense_Mutation_p.L72F|CCDC148_uc010fok.1_Missense_Mutation_p.L138F|CCDC148_uc002tzs.1_Missense_Mutation_p.L224F	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	224										ovary(2)	2						TTGAAGATTTCAAATCAGGGT	0.353													0	0	0	1	0	18	52										G	159195330	C	G	159195330	3	3	83	1	0	0	0	0	1	0	0	0	2782	825	29	1	1187	1	CCDC148	2	159195330	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	5603811	159195330	84004043	78	24922										
PLA2R1	22925	broad.mit.edu	37	chr2	160824175	160824175	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	catagaaactgaacactcttCactaccccagagtcctggag	7	13	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:160824175C>T	uc002ube.1	-	20	2986	c.2779G>A	c.(2779-2781)GAA>AAA	p.E927K	PLA2R1_uc010zcp.1_Missense_Mutation_p.E927K|PLA2R1_uc002ubf.2_Missense_Mutation_p.E927K	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	927	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GAACACTCTTCACTACCCCAG	0.403													0	0	0	1	0	18	87										T	160824175	C	T	160824175	3	4	83	1	0	0	0	0	1	0	0	0	12010	835	29	1	1664	1	PLA2R1	2	160824175	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1628845	160824175	82375198	79	24923										
FAP	2191	broad.mit.edu	37	chr2	163076436	163076436	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	catttcctcttacaaattctCtagaaggaaagaaagaaaga	6	7	2	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:163076436C>G	uc002ucd.2	-	7	622	c.414_splice	c.e7-1	p.G138_splice	FAP_uc010zct.1_Splice_Site_p.G113_splice|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Splice_Site_p.G105_splice	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit						endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TACAAATTCTCTAGAAGGAAA	0.294													0	0	0	1	0	16	28										G	163076436	C	G	163076436	5	3	83	1	0	0	0	0	0	0	1	0	5673	927	32	1	1949	1	FAP	2	163076436	Splice_Site	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2252261	163076436	80122937	80	24924										
SCN3A	6328	broad.mit.edu	37	chr2	165956858	165956858	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcttagaggtcttaaagctCttaatgtccgtaatgatttg	8	7	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:165956858C>G	uc002ucx.2	-	22	4412	c.3920G>C	c.(3919-3921)AGA>ACA	p.R1307T	SCN3A_uc002ucy.2_Missense_Mutation_p.R1258T|SCN3A_uc002ucz.2_Missense_Mutation_p.R1258T|SCN3A_uc002uda.1_Missense_Mutation_p.R1127T|SCN3A_uc002udb.1_Missense_Mutation_p.R1127T	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1307	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TCTTAAAGCTCTTAATGTCCG	0.378													0	0	0	1	0	7	66										G	165956858	C	G	165956858	3	3	83	1	0	0	0	0	1	0	0	0	13918	913	32	1	2110	1	SCN3A	2	165956858	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2880422	165956858	77242515	81	24925										
SCN2A	6326	broad.mit.edu	37	chr2	166243479	166243479	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcgttactactatttcactaTtggatggaatatttttgatt	6	5	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:166243479T>C	uc002udc.2	+	26	5065	c.4775T>C	c.(4774-4776)ATT>ACT	p.I1592T	SCN2A_uc002udd.2_Missense_Mutation_p.I1592T|SCN2A_uc002ude.2_Missense_Mutation_p.I1592T	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1592	Helical; Name=S3 of repeat IV; (Potential).|IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TATTTCACTATTGGATGGAAT	0.343													0	0	0	1	0	18	72										C	166243479	T	C	166243479	3	2	83	1	0	0	0	0	1	0	0	0	13916	1493	52	5	4969	5	SCN2A	2	166243479	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	286621	166243479	76955894	82	24926										
SCN1A	6323	broad.mit.edu	37	chr2	166901813	166901813	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actgggctctctggaatgttCtgaggcagttgccgttgctg	14	9	2	1	rs138602926		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:166901813C>G	uc010zcz.1	-	10	1420	c.1402G>C	c.(1402-1404)GAA>CAA	p.E468Q	SCN1A_uc002udo.3_Missense_Mutation_p.E337Q|SCN1A_uc010fpk.2_Missense_Mutation_p.E337Q	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	468						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTGGAATGTTCTGAGGCAGTT	0.458													0	0	0	1	0	8	115										G	166901813	C	G	166901813	3	3	83	1	0	0	0	0	1	0	0	0	13914	922	32	1	4695	1	SCN1A	2	166901813	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	658334	166901813	76297560	83	24927										
PDE11A	50940	broad.mit.edu	37	chr2	178528629	178528629	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcagatgctatcaatccactCcagttgcaaccgaggcagtt	9	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:178528629C>A	uc002ulq.2	-	19	2929	c.2611G>T	c.(2611-2613)GAG>TAG	p.E871*	PDE11A_uc010zfd.1_Nonsense_Mutation_p.E62*|PDE11A_uc002ulp.2_Nonsense_Mutation_p.E427*|PDE11A_uc002ulr.2_Nonsense_Mutation_p.E621*|PDE11A_uc002uls.1_Nonsense_Mutation_p.E513*|PDE11A_uc002ult.1_Nonsense_Mutation_p.E621*|PDE11A_uc002ulu.1_Nonsense_Mutation_p.E513*	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	871	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAATCCACTCCAGTTGCAAC	0.438									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				1	0	7.93312e-07	1	8.13734e-07	13	51										A	178528629	C	A	178528629	4	1	83	1	0	0	0	0	0	1	0	0	11631	864	30	3	198	3	PDE11A	2	178528629	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	11626816	178528629	64670744	84	24928										
PDE11A	50940	broad.mit.edu	37	chr2	178545621	178545621	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actgacaagttcaaagaattCagttctcctcctgcaggaaa	7	10	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:178545621C>G	uc002ulq.2	-	16	2674	c.2356G>C	c.(2356-2358)GAA>CAA	p.E786Q	PDE11A_uc002ulp.2_Missense_Mutation_p.E342Q|PDE11A_uc002ulr.2_Missense_Mutation_p.E536Q|PDE11A_uc002uls.1_Missense_Mutation_p.E428Q|PDE11A_uc002ult.1_Missense_Mutation_p.E536Q|PDE11A_uc002ulu.1_Missense_Mutation_p.E428Q	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	786	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAAAGAATTCAGTTCTCCTC	0.353									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	1	0	4	23										G	178545621	C	G	178545621	3	3	83	1	0	0	0	0	1	0	0	0	11631	835	29	1	465	1	PDE11A	2	178545621	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	16992	178545621	64653752	85	24929										
TTN	7273	broad.mit.edu	37	chr2	179596906	179596906	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcagtcttagaactgcagtaGactccacaaaagacattctg	7	10	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:179596906G>C	uc010zfg.1	-	54	13282	c.13058C>G	c.(13057-13059)TCT>TGT	p.S4353C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S1014C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGCAGTAGACTCCACAAA	0.433													0	0	0	1	0	59	151										C	179596906	G	C	179596906	3	2	83	1	0	0	0	0	1	0	0	0	16732	942	33	1	87963	1	TTN	2	179596906	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1051285	179596906	63602467	86	24930										
ANKRD44	91526	broad.mit.edu	37	chr2	197870475	197870475	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gttatctttgaaacaacagtCctcctcagaaagagccattt	6	10	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:197870475C>T	uc002uua.1	-	21	2292	c.2215G>A	c.(2215-2217)GAC>AAC	p.D739N	ANKRD44_uc002utz.3_Missense_Mutation_p.D471N	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	764	ANK 22.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAACAACAGTCCTCCTCAGAA	0.522													0	0	0	1	0	10	126										T	197870475	C	T	197870475	3	4	83	1	0	0	0	0	1	0	0	0	672	855	30	1	568	1	ANKRD44	2	197870475	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	18273569	197870475	45328898	87	24931										
SATB2	23314	broad.mit.edu	37	chr2	200137286	200137286	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctaaggagatctttgtgcgaGaccggggctttttggcacaa	13	8	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:200137286G>A	uc002uuy.1	-	11	2667	c.1850C>T	c.(1849-1851)TCT>TTT	p.S617F	SATB2_uc010fsq.1_Missense_Mutation_p.S499F|SATB2_uc002uuz.1_Missense_Mutation_p.S617F|SATB2_uc002uva.1_Missense_Mutation_p.S617F	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	617	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTTGTGCGAGACCGGGGCTT	0.557													0	0	0	1	0	24	66										A	200137286	G	A	200137286	3	1	83	1	0	0	0	0	1	0	0	0	13854	942	33	1	355	1	SATB2	2	200137286	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2266811	200137286	43062087	88	24932										
ABI2	10152	broad.mit.edu	37	chr2	204244965	204244965	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taaagagaaagttgcaagaaGagaaattggtattttgacta	10	2	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:204244965G>A	uc002vaa.2	+	3	555	c.320G>A	c.(319-321)AGA>AAA	p.R107K	ABI2_uc010zig.1_RNA|ABI2_uc002uzz.2_Missense_Mutation_p.R107K|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Missense_Mutation_p.R107K|ABI2_uc010zij.1_Missense_Mutation_p.R51K|ABI2_uc002vab.2_Missense_Mutation_p.R62K|ABI2_uc010zik.1_5'UTR|ABI2_uc010zil.1_5'UTR|ABI2_uc010zim.1_5'UTR	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	107	t-SNARE coiled-coil homology.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						GTTGCAAGAAGAGAAATTGGT	0.299													0	0	0	1	0	17	48										A	204244965	G	A	204244965	3	1	83	1	0	0	0	0	1	0	0	0	89	942	33	1	330	1	ABI2	2	204244965	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4107679	204244965	38954408	89	24933										
PIKFYVE	200576	broad.mit.edu	37	chr2	209190134	209190134	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tctgtgttgcttatcattctCaactagaaatatcctttctc	4	10	4	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:209190134C>G	uc002vcz.2	+	20	2757	c.2599C>G	c.(2599-2601)CAA>GAA	p.Q867E	PIKFYVE_uc010fun.1_Missense_Mutation_p.Q548E|PIKFYVE_uc002vcy.1_Missense_Mutation_p.Q811E	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	867					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TTATCATTCTCAACTAGAAAT	0.433													0	0	0	1	0	19	64										G	209190134	C	G	209190134	3	3	83	1	0	0	0	0	1	0	0	0	11924	827	29	1	2684	1	PIKFYVE	2	209190134	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4945169	209190134	34009239	90	24934										
PTH2R	5746	broad.mit.edu	37	chr2	209307167	209307167	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gttccttggctgtggctattCtcatcattggttacttcagg	10	9	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:209307167C>G	uc002vdb.2	+	5	703	c.490C>G	c.(490-492)CTC>GTC	p.L164V	PTH2R_uc010zjb.1_Missense_Mutation_p.L175V	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	164	Helical; Name=1; (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TGTGGCTATTCTCATCATTGG	0.438													0	0	0	1	0	34	82										G	209307167	C	G	209307167	3	3	83	1	0	0	0	0	1	0	0	0	12760	913	32	1	508	1	PTH2R	2	209307167	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	117033	209307167	33892206	91	24935										
MAP2	4133	broad.mit.edu	37	chr2	210558518	210558518	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aactttttgaaatgagagttGatgacaaagataagattgaa	9	2	0	7			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:210558518G>T	uc002vde.1	+	7	1872	c.1624G>T	c.(1624-1626)GAT>TAT	p.D542Y	MAP2_uc002vdc.1_Missense_Mutation_p.D542Y|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D538Y	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	542					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATGAGAGTTGATGACAAAGA	0.383													1	0	2.12542e-12	1	2.21969e-12	28	64										T	210558518	G	T	210558518	3	4	83	1	0	0	0	0	1	0	0	0	9235	1290	45	3	1638	3	MAP2	2	210558518	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1251351	210558518	32640855	92	24936										
C2orf24	27013	broad.mit.edu	37	chr2	220039607	220039607	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcctcctccccttcatcatAgaggtacttactggccacca	5	17	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:220039607A>G	uc002vju.3	-	5	555	c.403T>C	c.(403-405)TAT>CAT	p.Y135H	C2orf24_uc002vjv.2_Missense_Mutation_p.Y135H	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	135					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTTCATCATAGAGGTACTTA	0.582													0	0	0	1	0	19	42										G	220039607	A	G	220039607	3	3	83	1	0	0	0	0	1	0	0	0	2159	420	15	5	845	5	C2orf24	2	220039607	Missense_Mutation	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	9481089	220039607	23159766	93	24937										
EPHA4	2043	broad.mit.edu	37	chr2	222347094	222347094	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcttggttggtggtcacagtGacagaaactgattggtctgg	15	6	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:222347094G>A	uc002vmq.2	-	5	1338	c.1296C>T	c.(1294-1296)GTC>GTT	p.V432V	EPHA4_uc002vmr.2_Silent_p.V432V|EPHA4_uc010zlm.1_Silent_p.V373V|EPHA4_uc010zln.1_Silent_p.V432V	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	432	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TGGTCACAGTGACAGAAACTG	0.373													0	0	0	1	0	8	125										A	222347094	G	A	222347094	2	1	83	1	0	0	0	0	0	0	0	1	5169	1277	45	1		1	EPHA4	2	222347094	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2307487	222347094	20852279	94	24938										
ALPPL2	251	broad.mit.edu	37	chr2	233274450	233274450	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttcgccgcctgcctggagccCtacaccgcctgcgacctggc	11	19	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:233274450C>G	uc002vss.3	+	11	1520	c.1467C>G	c.(1465-1467)CCC>CCG	p.P489P		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	489					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GCCTGGAGCCCTACACCGCCT	0.741													0	0	0	1	0	5	9										G	233274450	C	G	233274450	2	3	83	1	0	0	0	0	0	0	0	1	549	668	24	4		4	ALPPL2	2	233274450	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10927356	233274450	9924923	95	24939										
INPP5D	3635	broad.mit.edu	37	chr2	234102561	234102561	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acaggccacttccagggggaGatcaagctgcagacctctca	11	13	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:234102561G>C	uc010zmo.1	+	22	2703	c.2550G>C	c.(2548-2550)GAG>GAC	p.E850D	INPP5D_uc010zmp.1_Missense_Mutation_p.E849D	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	850					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCAGGGGGAGATCAAGCTGC	0.617													0	0	0	1	0	15	50										C	234102561	G	C	234102561	3	2	83	1	0	0	0	0	1	0	0	0	7756	933	33	1	2148	1	INPP5D	2	234102561	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	828111	234102561	9096812	96	24940										
USP40	55230	broad.mit.edu	37	chr2	234429685	234429685	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgcttctcttcagattctaaCtggcataaatttttaacgtg	6	8	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:234429685C>G	uc010zmr.1	-	16	2310	c.2310G>C	c.(2308-2310)CAG>CAC	p.Q770H	USP40_uc010zmt.1_Missense_Mutation_p.Q414H	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	758					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CAGATTCTAACTGGCATAAAT	0.343													0	0	0	1	0	9	27										G	234429685	C	G	234429685	3	3	83	1	0	0	0	0	1	0	0	0	17069	564	20	4	1497	4	USP40	2	234429685	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	327124	234429685	8769688	97	24941										
SLC6A11	6538	broad.mit.edu	37	chr3	10960123	10960123	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agcagggggtacccattgctGaggtggcagagtcaggtaag	17	7	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:10960123G>A	uc003bvz.2	+	8	1139	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	369					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ACCCATTGCTGAGGTGGCAGA	0.567													0	0	0	1	0	9	29										A	10960123	G	A	10960123	3	1	83	1	0	0	0	0	1	0	0	0	14674	1291	45	1	1135	1	SLC6A11	3	10960123	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		10960123	187062307	98	24942										
GRIP2	80852	broad.mit.edu	37	chr3	14563188	14563188	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctccacctgaaagagtgcctCgtggctgcactgccgcaggg	13	14	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:14563188C>T	uc011avi.1	-	8	964	c.964G>A	c.(964-966)GAG>AAG	p.E322K	GRIP2_uc011avh.1_5'UTR|GRIP2_uc003byu.1_3'UTR|GRIP2_uc003byv.1_3'UTR	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	225	PDZ 2.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						AAGAGTGCCTCGTGGCTGCAC	0.672													0	0	0	1	0	8	11										T	14563188	C	T	14563188	3	4	83	1	0	0	0	0	1	0	0	0	6788	893	31	1	2532	1	GRIP2	3	14563188	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3603065	14563188	183459242	99	24943										
SS18L2	51188	broad.mit.edu	37	chr3	42632421	42632421	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cttcgtaccggactggctgaGgggcaaggcggaagtcaatc	15	10	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42632421G>C	uc003clk.1	+	1	124	c.32G>C	c.(31-33)AGG>ACG	p.R11T	SEC22C_uc003cli.2_Intron	NM_016305	NP_057389	Q9UHA2	S18L2_HUMAN	synovial sarcoma translocation gene on	11											0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GACTGGCTGAGGGGCAAGGCG	0.572													0	0	0	1	0	12	49										C	42632421	G	C	42632421	3	2	83	1	0	0	0	0	1	0	0	0	15176	1000	35	4	34	4	SS18L2	3	42632421	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	28069233	42632421	155390009	100	24944										
NKTR	4820	broad.mit.edu	37	chr3	42680599	42680599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acatggagatctgcactcctGataggagttccccagcaaaa	9	11	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42680599G>C	uc003clo.2	+	13	3550	c.3403G>C	c.(3403-3405)GAT>CAT	p.D1135H	NKTR_uc003clm.1_Missense_Mutation_p.D882H|NKTR_uc003clp.2_Missense_Mutation_p.D882H|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.D1025H|NKTR_uc003clr.1_Missense_Mutation_p.D882H|NKTR_uc003cls.2_Missense_Mutation_p.D835H	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1135					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CTGCACTCCTGATAGGAGTTC	0.448													0	0	0	1	0	26	55										C	42680599	G	C	42680599	3	2	83	1	0	0	0	0	1	0	0	0	10448	1290	45	1	3449	1	NKTR	3	42680599	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	48178	42680599	155341831	101	24945										
KBTBD5	131377	broad.mit.edu	37	chr3	42727254	42727254	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgcgagttcccgtgccatcgCctggtgctggccgcctgcag	14	16	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42727254C>T	uc003clv.1	+	1	244	c.144C>T	c.(142-144)CGC>CGT	p.R48R		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	48	BTB.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CGTGCCATCGCCTGGTGCTGG	0.692													0	0	0	1	0	7	28										T	42727254	C	T	42727254	2	4	83	1	0	0	0	0	0	0	0	1	7996	726	26	2		2	KBTBD5	3	42727254	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	46655	42727254	155295176	102	24946										
ZNF445	353274	broad.mit.edu	37	chr3	44497005	44497005	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctccctcgaagactgggcctGagctggataggcagcatgcc	13	13	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:44497005G>C	uc003cnf.2	-	3	385	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	ZNF445_uc011azv.1_Missense_Mutation_p.Q13E|ZNF445_uc011azw.1_Missense_Mutation_p.Q13E	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	13					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GACTGGGCCTGAGCTGGATAG	0.567													0	0	0	1	0	5	44										C	44497005	G	C	44497005	3	2	83	1	0	0	0	0	1	0	0	0	17915	1299	45	1	3082	1	ZNF445	3	44497005	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1769751	44497005	153525425	103	24947										
ZNF197	10168	broad.mit.edu	37	chr3	44683588	44683588	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaaagggcagatacagtgaaGaaagtttccctttgtgaacg	12	6	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:44683588G>A	uc003cnm.2	+	6	1172	c.966G>A	c.(964-966)AAG>AAA	p.K322K	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	322					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ATACAGTGAAGAAAGTTTCCC	0.443													0	0	0	1	0	21	43										A	44683588	G	A	44683588	2	1	83	1	0	0	0	0	0	0	0	1	17756	933	33	1		1	ZNF197	3	44683588	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	186583	44683588	153338842	104	24948										
KLHL18	23276	broad.mit.edu	37	chr3	47385224	47385224	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtggcagaccagtggtgcctGattgtccccatgcacacgcg	13	13	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:47385224G>C	uc003crd.2	+	10	1644	c.1518G>C	c.(1516-1518)CTG>CTC	p.L506L	KLHL18_uc011bav.1_Silent_p.L394L	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	506	Kelch 5.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		AGTGGTGCCTGATTGTCCCCA	0.622													0	0	0	1	0	21	70										C	47385224	G	C	47385224	2	2	83	1	0	0	0	0	0	0	0	1	8373	1277	45	1		1	KLHL18	3	47385224	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2701636	47385224	150637206	105	24949										
CELSR3	1951	broad.mit.edu	37	chr3	48665891	48665891	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttccgaagcttctcctctttCtgcagttgcttcagcttcag	7	13	5	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:48665891C>T	uc003cuf.1	-	52	11991	c.11991G>A	c.(11989-11991)CAG>CAA	p.Q3997Q	SLC26A6_uc003cug.2_Silent_p.Q571Q|SLC26A6_uc003cuh.2_Silent_p.Q592Q|SLC26A6_uc010hke.2_Silent_p.Q443Q|SLC26A6_uc003cuk.2_Silent_p.Q485Q|SLC26A6_uc003cui.2_Silent_p.Q592Q|SLC26A6_uc003cuj.2_Silent_p.Q592Q|SLC26A6_uc011bbp.1_Silent_p.Q556Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTCCTCTTTCTGCAGTTGCT	0.388													0	0	0	1	0	38	96										T	48665891	C	T	48665891	2	4	83	1	0	0	0	0	0	0	0	1	3223	912	32	1		1	CELSR3	3	48665891	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1280667	48665891	149356539	106	24950										
RHOA	387	broad.mit.edu	37	chr3	49397643	49397643	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgtgcttgcagcaaggtttCacaagacaaggcacccagat	10	11	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:49397643C>T	uc003cwu.2	-	5	857	c.581G>A	c.(580-582)TGA>TAA	p.*194*	RHOA_uc010hku.2_Silent_p.*113*|GPX1_uc011bcl.1_5'Flank|GPX1_uc011bcm.1_5'Flank	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	194					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AGCAAGGTTTCACAAGACAAG	0.403													0	0	0	1	0	36	92										T	49397643	C	T	49397643	2	4	83	1	0	0	0	0	0	0	0	1	13331	837	29	1		1	RHOA	3	49397643	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	731752	49397643	148624787	107	24951										
RHOA	387	broad.mit.edu	37	chr3	49397721	49397721	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tagccatttcaaaaacctctCtcactccatctttggtcttt	3	13	5	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:49397721C>G	uc003cwu.2	-	5	779	c.503G>C	c.(502-504)AGA>ACA	p.R168T	RHOA_uc010hku.2_Missense_Mutation_p.R87T|GPX1_uc011bcl.1_5'Flank|GPX1_uc011bcm.1_5'Flank	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	168					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AAAAACCTCTCTCACTCCATC	0.493													0	0	0	1	0	40	104										G	49397721	C	G	49397721	3	3	83	1	0	0	0	0	1	0	0	0	13331	913	32	1	82	1	RHOA	3	49397721	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	78	49397721	148624709	108	24952										
PCBP4	57060	broad.mit.edu	37	chr3	51994209	51994209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atatctcgcccctcacctctCggatctccttgatcttggtg	7	15	5	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:51994209C>T	uc003dcd.1	-	5	779	c.383G>A	c.(382-384)CGA>CAA	p.R128Q	PCBP4_uc003dcb.1_Missense_Mutation_p.R94Q|PCBP4_uc003dcc.1_Missense_Mutation_p.R94Q|PCBP4_uc003dce.1_Missense_Mutation_p.R128Q|PCBP4_uc003dcf.1_Missense_Mutation_p.R128Q|PCBP4_uc003dcg.1_Missense_Mutation_p.R94Q|PCBP4_uc003dch.1_Missense_Mutation_p.R128Q|PCBP4_uc003dci.1_Missense_Mutation_p.R51Q|PCBP4_uc003dcj.1_Missense_Mutation_p.R128Q|PCBP4_uc003dck.1_Missense_Mutation_p.R128Q|PCBP4_uc003dcl.1_Missense_Mutation_p.R128Q	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	128	KH 2.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTCACCTCTCGGATCTCCTT	0.592													0	0	0	1	0	15	56										T	51994209	C	T	51994209	3	4	83	1	0	0	0	0	1	0	0	0	11503	884	31	1	860	1	PCBP4	3	51994209	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2596488	51994209	146028221	109	24953										
PBRM1	55193	broad.mit.edu	37	chr3	52692314	52692314	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agctgctccaggatctccttCaagtaagctggagaagactg	11	10	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:52692314C>G	uc003des.2	-	5	558	c.546G>C	c.(544-546)TTG>TTC	p.L182F	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.L182F|PBRM1_uc003der.2_Missense_Mutation_p.L182F|PBRM1_uc003det.2_Missense_Mutation_p.L182F|PBRM1_uc003deu.2_Missense_Mutation_p.L182F|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.L182F|PBRM1_uc010hmk.1_Missense_Mutation_p.L182F|PBRM1_uc003dey.2_Missense_Mutation_p.L182F|PBRM1_uc003dez.1_Missense_Mutation_p.L182F|PBRM1_uc003dfb.1_Missense_Mutation_p.L80F	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	182					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGATCTCCTTCAAGTAAGCTG	0.373			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	4	51										G	52692314	C	G	52692314	3	3	83	1	0	0	0	0	1	0	0	0	11491	825	29	1	4458	1	PBRM1	3	52692314	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	698105	52692314	145330116	110	24954										
ITIH4	3700	broad.mit.edu	37	chr3	52858879	52858879	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgctggattttcctgccactCatggagccgctcttgtcaat	9	12	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:52858879C>T	uc003dfz.2	-	7	891	c.855G>A	c.(853-855)ATG>ATA	p.M285I	ITIH4_uc011bel.1_Missense_Mutation_p.M15I|ITIH4_uc003dfy.2_Missense_Mutation_p.M149I|ITIH4_uc011bem.1_Missense_Mutation_p.M285I|ITIH4_uc011ben.1_Missense_Mutation_p.M285I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	285	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TCCTGCCACTCATGGAGCCGC	0.572													0	0	0	1	0	37	71										T	52858879	C	T	52858879	3	4	83	1	0	0	0	0	1	0	0	0	7906	826	29	1	2009	1	ITIH4	3	52858879	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	166565	52858879	145163551	111	24955										
PRKCD	5580	broad.mit.edu	37	chr3	53215603	53215603	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggcaacccaccttctgttctGtgtgcaaagactttgtctgg	10	11	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:53215603G>T	uc003dgl.2	+	6	873	c.520G>T	c.(520-522)GTG>TTG	p.V174L	PRKCD_uc003dgm.2_Missense_Mutation_p.V174L|PRKCD_uc003dgn.2_Missense_Mutation_p.V174L|PRKCD_uc010hmt.1_5'Flank	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	174	Phorbol-ester/DAG-type 1.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CTTCTGTTCTGTGTGCAAAGA	0.567													1	0	5.3912e-06	1	5.48653e-06	19	59										T	53215603	G	T	53215603	3	4	83	1	0	0	0	0	1	0	0	0	12509	1377	48	4	534	4	PRKCD	3	53215603	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	356724	53215603	144806827	112	24956										
DCBLD2	131566	broad.mit.edu	37	chr3	98538214	98538214	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cacagatgatgctgttatttGaggatccgcgatcacaccag	10	10	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:98538214G>A	uc003dtd.2	-	8	1282	c.919C>T	c.(919-921)CAA>TAA	p.Q307*	DCBLD2_uc003dte.2_Nonsense_Mutation_p.Q307*	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	307	Extracellular (Potential).|F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GCTGTTATTTGAGGATCCGCG	0.448													0	0	0	1	0	14	21										A	98538214	G	A	98538214	4	1	83	1	0	0	0	0	0	1	0	0	4281	1299	45	1	1444	1	DCBLD2	3	98538214	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	45322611	98538214	99484216	113	24957										
CEP97	79598	broad.mit.edu	37	chr3	101476575	101476575	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccagcctctgtacacactacGagatattctcgaaatgatct	6	12	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:101476575G>A	uc003dvk.1	+	9	1152	c.1125G>A	c.(1123-1125)ACG>ACA	p.T375T	CEP97_uc010hpm.1_Silent_p.T341T|CEP97_uc011bhf.1_Intron|CEP97_uc003dvl.1_Silent_p.T71T|CEP97_uc003dvm.1_Silent_p.T213T	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	375	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						TACACACTACGAGATATTCTC	0.398													0	0	0	1	0	21	62										A	101476575	G	A	101476575	2	1	83	1	0	0	0	0	0	0	0	1	3263	1045	37	1		1	CEP97	3	101476575	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2938361	101476575	96545855	114	24958										
WDR52	55779	broad.mit.edu	37	chr3	113098284	113098284	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttctcctcttcctcctcctGaaattctttttctccatctt	1	15	5	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:113098284G>A	uc003eae.1	-	17	2213	c.2167C>T	c.(2167-2169)CAG>TAG	p.Q723*		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	723	Glu-rich.									central_nervous_system(1)	1						tcctcctcctGAAATTCTTTT	0.333													0	0	0	1	0	29	72										A	113098284	G	A	113098284	4	1	83	1	0	0	0	0	0	1	0	0	17301	1299	45	1	3488	1	WDR52	3	113098284	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	11621709	113098284	84924146	115	24959										
IGSF11	152404	broad.mit.edu	37	chr3	118647366	118647366	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtcactcacctaacactgtGagaccggtgaccccaatgtt	8	13	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:118647366G>A	uc003ebw.2	-	3	661	c.414C>T	c.(412-414)CTC>CTT	p.L138L	IGSF11_uc011biv.1_Silent_p.L138L|IGSF11_uc003ebx.2_Silent_p.L138L|IGSF11_uc003eby.2_Silent_p.L137L|IGSF11_uc003ebz.2_Silent_p.L137L|IGSF11_uc010hqs.2_Silent_p.L137L	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	138	Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CTAACACTGTGAGACCGGTGA	0.493													0	0	0	1	0	12	42										A	118647366	G	A	118647366	2	1	83	1	0	0	0	0	0	0	0	1	7598	1277	45	1		1	IGSF11	3	118647366	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	5549082	118647366	79375064	116	24960										
GOLGB1	2804	broad.mit.edu	37	chr3	121414111	121414111	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcttcacttagagagtctttCtcagacattaaagactgaaa	6	8	4	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:121414111C>T	uc003eei.3	-	13	5370	c.5244G>A	c.(5242-5244)GAG>GAA	p.E1748E	GOLGB1_uc010hrc.2_Silent_p.E1753E|GOLGB1_uc003eej.3_Silent_p.E1714E|GOLGB1_uc011bjm.1_Silent_p.E1634E|GOLGB1_uc010hrd.1_Silent_p.E1712E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1748	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		GAGAGTCTTTCTCAGACATTA	0.378													0	0	0	1	0	42	99										T	121414111	C	T	121414111	2	4	83	1	0	0	0	0	0	0	0	1	6565	912	32	1		1	GOLGB1	3	121414111	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2766745	121414111	76608319	117	24961										
ALG1L	200810	broad.mit.edu	37	chr3	125649405	125649405	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggcagatgtggctacctgcaGagctgccagttcctctgagt	13	11	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:125649405G>C	uc003eig.1	-	5	507	c.343C>G	c.(343-345)CTG>GTG	p.L115V		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	115							transferase activity, transferring glycosyl groups				0						GCTACCTGCAGAGCTGCCAGT	0.582													0	0	0	1	0	17	33										C	125649405	G	C	125649405	3	2	83	1	0	0	0	0	1	0	0	0	517	933	33	1	228	1	ALG1L	3	125649405	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4235294	125649405	72373025	118	24962										
TMCC1	23023	broad.mit.edu	37	chr3	129373852	129373852	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ataggactgatacgcgatttTttcttccatgcttgccagtt	8	9	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:129373852T>A	uc003emz.3	-	6	2107	c.1606A>T	c.(1606-1608)AAA>TAA	p.K536*	TMCC1_uc003emy.3_Nonsense_Mutation_p.K212*|TMCC1_uc011blc.1_Nonsense_Mutation_p.K357*|TMCC1_uc010htg.2_Nonsense_Mutation_p.K422*	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	536	Potential.					integral to membrane				skin(1)	1						TACGCGATTTTTTCTTCCATG	0.423													0	0	0	1	0	23	70										A	129373852	T	A	129373852	4	1	83	1	0	0	0	0	0	1	0	0	15989	1850	64	5	363	5	TMCC1	3	129373852	Nonsense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	3724447	129373852	68648578	119	24963										
WWTR1	25937	broad.mit.edu	37	chr3	149260194	149260194	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	attctctgaagccgcagtttCtgctgctgctgctgctgagt	11	11	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:149260194C>G	uc003exe.2	-	3	715	c.699G>C	c.(697-699)CAG>CAC	p.Q233H	WWTR1_uc003exf.2_Missense_Mutation_p.Q233H|WWTR1_uc011bns.1_Missense_Mutation_p.Q233H|WWTR1_uc003exh.2_Missense_Mutation_p.Q233H	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	233	Potential.|Gln-rich.				hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCGCAGTTTCTGCTGCTGCT	0.577													0	0	0	1	0	8	40										G	149260194	C	G	149260194	3	3	83	1	0	0	0	0	1	0	0	0	17414	912	32	1	519	1	WWTR1	3	149260194	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	19886342	149260194	48762236	120	24964										
IGSF10	285313	broad.mit.edu	37	chr3	151163897	151163897	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcatagggttaaggggtgggAagggaagctccttctttgtt	16	5	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:151163897A>T	uc011bod.1	-	4	3872	c.3872T>A	c.(3871-3873)TTC>TAC	p.F1291Y		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1291					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGGGTGGGAAGGGAAGCTC	0.433													0	0	0	1	0	53	124										T	151163897	A	T	151163897	3	4	83	1	0	0	0	0	1	0	0	0	7597	246	9	5	4059	5	IGSF10	3	151163897	Missense_Mutation	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	1903703	151163897	46858533	121	24965										
SGEF	26084	broad.mit.edu	37	chr3	153870637	153870637	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gatacgaatgtttaaaaattCtaaagaactgagtgatacaa	7	4	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:153870637C>G	uc011bog.1	+	6	1614	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	SGEF_uc011boh.1_Missense_Mutation_p.S468C	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	468	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTAAAAATTCTAAAGAACTG	0.363													0	0	0	1	0	5	8										G	153870637	C	G	153870637	3	3	83	1	0	0	0	0	1	0	0	0	14205	913	32	1	1421	1	SGEF	3	153870637	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2706740	153870637	44151793	122	24966										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	6	50										A	178936091	G	A	178936091	3	1	83	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	25065454	178936091	19086339	123	24967										
CHRD	8646	broad.mit.edu	37	chr3	184103022	184103022	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gctgaagggattctatggctCagaggtaaggatgtgatggt	16	4	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:184103022C>T	uc003fov.2	+	14	2060	c.1814C>T	c.(1813-1815)TCA>TTA	p.S605L	CHRD_uc003fow.2_Missense_Mutation_p.S235L|CHRD_uc003fox.2_Missense_Mutation_p.S605L|CHRD_uc003foy.2_Missense_Mutation_p.S235L|CHRD_uc010hyc.2_Missense_Mutation_p.S195L|CHRD_uc011brr.1_Missense_Mutation_p.S235L	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	605	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCTATGGCTCAGAGGTAAGG	0.582													0	0	0	1	0	18	62										T	184103022	C	T	184103022	3	4	83	1	0	0	0	0	1	0	0	0	3372	838	29	1	1868	1	CHRD	3	184103022	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	5166931	184103022	13919408	124	24968										
WHSC1	7468	broad.mit.edu	37	chr4	1977056	1977056	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttaactacaacctcgattgtCtgggcaatgaaaaaacggtc	8	9	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:1977056C>T	uc003gdz.3	+	20	3726	c.3550C>T	c.(3550-3552)CTG>TTG	p.L1184L	WHSC1_uc003geb.3_Silent_p.L1184L|WHSC1_uc003gec.3_Silent_p.L1184L|WHSC1_uc003ged.3_Silent_p.L1184L|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.L403L|WHSC1_uc011bvh.1_Silent_p.L245L|WHSC1_uc010icf.2_Silent_p.L532L	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1184	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCTCGATTGTCTGGGCAATGA	0.532			T	IGH@	MM								0	0	0	1	0	18	24										T	1977056	C	T	1977056	2	4	83	1	0	0	0	0	0	0	0	1	17359	912	32	1		1	WHSC1	4	1977056	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		1977056	189177220	125	24969										
WHSC2	7469	broad.mit.edu	37	chr4	1991499	1991499	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgctttaactgaaaatgcttCaccgggggagtgaggggtcc	14	9	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:1991499C>T	uc003gem.2	-	3	753	c.513G>A	c.(511-513)GTG>GTA	p.V171V	WHSC2_uc003gel.2_Silent_p.V85V|WHSC2_uc003gen.2_Silent_p.V25V	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	160					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GAAAATGCTTCACCGGGGGAG	0.612													0	0	0	1	0	50	94										T	1991499	C	T	1991499	2	4	83	1	0	0	0	0	0	0	0	1	17361	813	29	1		1	WHSC2	4	1991499	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	14443	1991499	189162777	126	24970										
HAUS3	79441	broad.mit.edu	37	chr4	2238161	2238161	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caattcttttttcttattctCtccctccaaaacttggtaaa	2	11	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:2238161C>G	uc003ges.1	-	4	1602	c.1372G>C	c.(1372-1374)GAG>CAG	p.E458Q	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Missense_Mutation_p.E458Q|HAUS3_uc003get.1_Missense_Mutation_p.E458Q	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	458	Potential.				cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						TTCTTATTCTCTCCCTCCAAA	0.313													0	0	0	1	0	22	33										G	2238161	C	G	2238161	3	3	83	1	0	0	0	0	1	0	0	0	6967	922	32	1	447	1	HAUS3	4	2238161	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	246662	2238161	188916115	127	24971										
ZBTB49	166793	broad.mit.edu	37	chr4	4322918	4322918	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctttggacaaccacggcggtGaccccctgggcagtcgagca	13	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:4322918G>A	uc003ghu.2	+	8	2348	c.2173G>A	c.(2173-2175)GAC>AAC	p.D725N	uc003ghw.2_5'Flank|ZBTB49_uc003ghv.2_Missense_Mutation_p.D208N|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Missense_Mutation_p.D303N	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCACGGCGGTGACCCCCTGGG	0.587													0	0	0	1	0	12	15										A	4322918	G	A	4322918	3	1	83	1	0	0	0	0	1	0	0	0	17547	1290	45	1	2199	1	ZBTB49	4	4322918	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2084757	4322918	186831358	128	24972										
MRFAP1L1	114932	broad.mit.edu	37	chr4	6711276	6711276	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcgttgatgaccgggagcagGaactgctcgaaatcctcctc	11	12	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:6711276G>A	uc003gjn.2	-	1	321	c.81C>T	c.(79-81)TTC>TTT	p.F27F	MRFAP1L1_uc003gjo.2_Silent_p.F27F	NM_203462	NP_982287	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	27											0						CCGGGAGCAGGAACTGCTCGA	0.632													0	0	0	1	0	21	32										A	6711276	G	A	6711276	2	1	83	1	0	0	0	0	0	0	0	1	9762	1165	41	1		1	MRFAP1L1	4	6711276	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2388358	6711276	184443000	129	24973										
TBC1D14	57533	broad.mit.edu	37	chr4	7016174	7016174	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aatttcatattatctccctaGatgttgacttattttgctgc	5	8	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:7016174G>A	uc011bwg.1	+	12	1727	c.1648_splice	c.e12-1	p.M550_splice	TBC1D14_uc003gjs.3_Splice_Site_p.M550_splice|TBC1D14_uc010idh.2_Splice_Site_p.M270_splice|TBC1D14_uc011bwh.1_Splice_Site_p.M197_splice|TBC1D14_uc003gju.3_Splice_Site_p.M41_splice	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a							intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						TATCTCCCTAGATGTTGACTT	0.299													0	0	0	1	0	4	7										A	7016174	G	A	7016174	5	1	83	1	0	0	0	0	0	0	1	0	15600	956	33	1	1696	1	TBC1D14	4	7016174	Splice_Site	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	304898	7016174	184138102	130	24974										
UGT2B10	7365	broad.mit.edu	37	chr4	69870721	69870721	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tactggaaccaggtgaggtcAtgggctgcaactcgaaggtg	15	8	1	1	rs111542944		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:69870721A>G	uc011cao.1	-	9	1465	c.1329T>C	c.(1327-1329)CAT>CAC	p.H443H	UGT2B10_uc011can.1_Silent_p.H359H			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	480					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						AGGTGAGGTCATGGGCTGCAA	0.478													0	0	0	1	0	6	96										G	69870721	A	G	69870721	2	3	83	1	0	0	0	0	0	0	0	1	16953	214	8	5		5	UGT2B10	4	69870721	Silent	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	62854547	69870721	121283555	131	24975										
FRAS1	80144	broad.mit.edu	37	chr4	79229280	79229280	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaagcactgcttggcctgcaGagatcccctccacgtgctga	11	14	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:79229280G>C	uc003hlb.2	+	15	2035	c.1595G>C	c.(1594-1596)AGA>ACA	p.R532T	FRAS1_uc003hkw.2_Missense_Mutation_p.R532T|FRAS1_uc003hky.1_Missense_Mutation_p.R236T|FRAS1_uc003hkz.2_Missense_Mutation_p.R236T|FRAS1_uc003hla.1_Missense_Mutation_p.R43T	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	532	FU 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TTGGCCTGCAGAGATCCCCTC	0.577													0	0	0	1	0	5	11										C	79229280	G	C	79229280	3	2	83	1	0	0	0	0	1	0	0	0	6042	942	33	1	1653	1	FRAS1	4	79229280	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	9358559	79229280	111924996	132	24976										
NUDT6	11162	broad.mit.edu	37	chr4	123814162	123814162	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggtgatgggagttgtattttCagtcttcgccaggtcattga	13	6	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:123814162C>T	uc003iew.2	-	5	804	c.772G>A	c.(772-774)GAA>AAA	p.E258K	FGF2_uc003iev.1_3'UTR|NUDT6_uc003iex.2_Missense_Mutation_p.E89K	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	258	Nudix hydrolase.			KTEN -> RTKH (in Ref. 4; AAA67062).		mitochondrion|nucleus	growth factor activity|hydrolase activity				0						GTTGTATTTTCAGTCTTCGCC	0.448													0	0	0	1	0	8	69										T	123814162	C	T	123814162	3	4	83	1	0	0	0	0	1	0	0	0	10743	835	29	1	182	1	NUDT6	4	123814162	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	44584882	123814162	67340114	133	24977										
ODZ3	55714	broad.mit.edu	37	chr4	183714402	183714402	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgttcaatatcggttggatGaagatggtttcctacgtcaa	10	6	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:183714402G>A	uc003ivd.1	+	25	6614	c.6577G>A	c.(6577-6579)GAA>AAA	p.E2193K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2193	Extracellular (Potential).|YD 20.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCGGTTGGATGAAGATGGTTT	0.483													0	0	0	1	0	20	41										A	183714402	G	A	183714402	3	1	83	1	0	0	0	0	1	0	0	0	10836	1291	45	1	6675	1	ODZ3	4	183714402	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	59900240	183714402	7439874	134	24978										
SNX25	83891	broad.mit.edu	37	chr4	186185662	186185662	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cagatgatgaagtaagatttCtacaaacgtgttctcgggtt	10	6	2	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:186185662C>G	uc003ixh.2	+	4	499	c.310C>G	c.(310-312)CTA>GTA	p.L104V		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	104	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AGTAAGATTTCTACAAACGTG	0.413													0	0	0	1	0	28	42										G	186185662	C	G	186185662	3	3	83	1	0	0	0	0	1	0	0	0	14896	912	32	1	320	1	SNX25	4	186185662	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2471260	186185662	4968614	135	24979										
TLR3	7098	broad.mit.edu	37	chr4	186997899	186997899	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gactgcagccacctgaagttGactcaggtacccgatgatct	10	12	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:186997899G>A	uc003iyq.2	+	2	227	c.126G>A	c.(124-126)TTG>TTA	p.L42L		NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	42	LRRNT.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ACCTGAAGTTGACTCAGGTAC	0.498													0	0	0	1	0	4	47										A	186997899	G	A	186997899	2	1	83	1	0	0	0	0	0	0	0	1	15949	1281	45	1		1	TLR3	4	186997899	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	812237	186997899	4156377	136	24980										
IRX1	79192	broad.mit.edu	37	chr5	3600251	3600251	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccttcctgggcgttggcgctCcccacgccgcgccccatggc	12	20	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:3600251C>T	uc003jde.2	+	2	1241	c.1189C>T	c.(1189-1191)CCC>TCC	p.P397S		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CGTTGGCGCTCCCCACGCCGC	0.662													0	0	0	1	0	7	39										T	3600251	C	T	3600251	3	4	83	1	0	0	0	0	1	0	0	0	7843	855	30	1	1195	1	IRX1	5	3600251	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		3600251	177315009	137	24981										
ADCY2	108	broad.mit.edu	37	chr5	7414870	7414870	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtgttttggaggcaccgtctCtccctgggaccaggtaaggt	14	10	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7414870C>T	uc003jdz.1	+	2	462	c.395C>T	c.(394-396)TCT>TTT	p.S132F		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	132					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGCACCGTCTCTCCCTGGGAC	0.423													0	0	0	1	0	10	78										T	7414870	C	T	7414870	3	4	83	1	0	0	0	0	1	0	0	0	294	913	32	1	401	1	ADCY2	5	7414870	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3814619	7414870	173500390	138	24982										
MTRR	4552	broad.mit.edu	37	chr5	7878257	7878257	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gagattcgatgattcaggaaGaaaggattctgaggttttga	13	3	2	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7878257G>A	uc003jed.2	+	5	713	c.683G>A	c.(682-684)AGA>AAA	p.R228K	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.R201K|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	228	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GATTCAGGAAGAAAGGATTCT	0.468													0	0	0	1	0	9	177										A	7878257	G	A	7878257	3	1	83	1	0	0	0	0	1	0	0	0	9961	942	33	1	701	1	MTRR	5	7878257	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	463387	7878257	173037003	139	24983										
MTRR	4552	broad.mit.edu	37	chr5	7878391	7878391	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctctgaatattcctggtttaCccccagaatatttacaggta	6	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7878391C>T	uc003jed.2	+	5	847	c.817C>T	c.(817-819)CCC>TCC	p.P273S	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.P246S|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	273	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TCCTGGTTTACCCCCAGAATA	0.423													0	0	0	1	0	41	242										T	7878391	C	T	7878391	3	4	83	1	0	0	0	0	1	0	0	0	9961	507	18	2	835	2	MTRR	5	7878391	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	134	7878391	173036869	140	24984										
MTRR	4552	broad.mit.edu	37	chr5	7892992	7892992	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcagccaaacatacatgcatCccatgaagacagcgggaaag	9	11	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7892992C>T	uc003jed.2	+	11	1634	c.1604C>T	c.(1603-1605)TCC>TTC	p.S535F	MTRR_uc003jee.3_Missense_Mutation_p.S508F|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	535	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	ATACATGCATCCCATGAAGAC	0.448													0	0	0	1	0	21	71										T	7892992	C	T	7892992	3	4	83	1	0	0	0	0	1	0	0	0	9961	855	30	1	1646	1	MTRR	5	7892992	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	14601	7892992	173022268	141	24985										
FAM173B	134145	broad.mit.edu	37	chr5	10235356	10235356	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccgaaaataacaacgttcgaGtactgcgaaaaagtaacctg	8	9	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:10235356G>T	uc003jeo.2	-	4	491	c.462C>A	c.(460-462)TAC>TAA	p.Y154*	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Intron	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	154						integral to membrane				kidney(1)|central_nervous_system(1)	2						CAACGTTCGAGTACTGCGAAA	0.428													1	0	0.000157383	1	0.000159539	6	42										T	10235356	G	T	10235356	4	4	83	1	0	0	0	0	0	1	0	0	5494	1024	36	4	247	4	FAM173B	5	10235356	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2342364	10235356	170679904	142	24986										
CDH9	1007	broad.mit.edu	37	chr5	26890543	26890543	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tagctccaacttacttatttCtgtggctgtaacagtgatgt	8	8	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:26890543C>T	uc003jgs.1	-	8	1553	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	CDH9_uc011cnv.1_Missense_Mutation_p.E55K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	462	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTACTTATTTCTGTGGCTGTA	0.393													0	0	0	1	0	21	126										T	26890543	C	T	26890543	3	4	83	1	0	0	0	0	1	0	0	0	3117	922	32	1	1005	1	CDH9	5	26890543	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	16655187	26890543	154024717	143	24987										
ADAMTS12	81792	broad.mit.edu	37	chr5	33596062	33596062	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggtggacaagccttttcatgGcacttcttctgtctcccatt	8	12	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:33596062G>T	uc003jia.1	-	17	2794	c.2631C>A	c.(2629-2631)TGC>TGA	p.C877*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.C792*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	877	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCTTTTCATGGCACTTCTTCT	0.527										HNSCC(64;0.19)			1	0	2.94398e-08	1	3.05608e-08	17	112										T	33596062	G	T	33596062	4	4	83	1	0	0	0	0	0	1	0	0	257	1195	42	4	2185	4	ADAMTS12	5	33596062	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6705519	33596062	147319198	144	24988										
UGT3A1	133688	broad.mit.edu	37	chr5	35957426	35957426	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aaggcattgtgcatcttcttGaggacttcctgggactgatg	12	8	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:35957426G>C	uc003jjv.1	-	5	1096	c.939C>G	c.(937-939)CTC>CTG	p.L313L	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.L313L|UGT3A1_uc011cor.1_Silent_p.L279L	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	313	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATCTTCTTGAGGACTTCCT	0.493													0	0	0	1	0	6	85										C	35957426	G	C	35957426	2	2	83	1	0	0	0	0	0	0	0	1	16960	1277	45	1		1	UGT3A1	5	35957426	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2361364	35957426	144957834	145	24989										
RANBP3L	202151	broad.mit.edu	37	chr5	36265595	36265595	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cactactttgcacaagagctGatgtcataaaaacattgttt	6	8	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:36265595G>C	uc003jkh.2	-	5	789	c.296C>G	c.(295-297)TCA>TGA	p.S99*	RANBP3L_uc011cow.1_Nonsense_Mutation_p.S124*	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	99					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CACAAGAGCTGATGTCATAAA	0.299													0	0	0	1	0	15	75										C	36265595	G	C	36265595	4	2	83	1	0	0	0	0	0	1	0	0	13030	1294	45	1	1141	1	RANBP3L	5	36265595	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	308169	36265595	144649665	146	24990										
NUP155	9631	broad.mit.edu	37	chr5	37371053	37371053	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcagatgtagaggccggcatCgccgcgcccaacaaagaaga	13	12	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:37371053C>T	uc003jku.1	-	1	145	c.27G>A	c.(25-27)GCG>GCA	p.A9A	NUP155_uc003jkt.1_5'Flank|NUP155_uc010iuz.1_Silent_p.A9A	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	9					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGGCCGGCATCGCCGCGCCCA	0.537													0	0	0	1	0	17	80										T	37371053	C	T	37371053	2	4	83	1	0	0	0	0	0	0	0	1	10756	871	31	1		1	NUP155	5	37371053	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1105458	37371053	143544207	147	24991										
PLCXD3	345557	broad.mit.edu	37	chr5	41382631	41382631	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtagaagctgaaggaatcatGagaccctaggagaataacaa	11	6	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:41382631G>A	uc003jmm.1	-	2	211	c.109C>T	c.(109-111)CAT>TAT	p.H37Y		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	37	PI-PLC X-box.	By similarity.			intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						AAGGAATCATGAGACCCTAGG	0.458													0	0	0	1	0	36	47										A	41382631	G	A	41382631	3	1	83	1	0	0	0	0	1	0	0	0	12043	1290	45	1	864	1	PLCXD3	5	41382631	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4011578	41382631	139532629	148	24992										
PARP8	79668	broad.mit.edu	37	chr5	50091139	50091139	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctactccagtgcccccaagtCatccaaaactgagcttttca	5	15	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:50091139C>T	uc003jon.3	+	13	1498	c.1316C>T	c.(1315-1317)TCA>TTA	p.S439L	PARP8_uc011cpz.1_Missense_Mutation_p.S331L|PARP8_uc003joo.2_Missense_Mutation_p.S439L|PARP8_uc003jop.2_Missense_Mutation_p.S439L	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	439						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GCCCCCAAGTCATCCAAAACT	0.438													0	0	0	1	0	22	50										T	50091139	C	T	50091139	3	4	83	1	0	0	0	0	1	0	0	0	11465	838	29	1	1362	1	PARP8	5	50091139	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	8708508	50091139	130824121	149	24993										
RNF180	285671	broad.mit.edu	37	chr5	63510308	63510308	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagttgaagaatctaagaagGaaacaacgaaggcgtgaaag	12	4	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:63510308G>A	uc003jti.2	+	4	1265	c.1155G>A	c.(1153-1155)AGG>AGA	p.R385R	RNF180_uc003jth.3_Silent_p.R385R|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	385	Interaction with ZIC2 (By similarity).|Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		ATCTAAGAAGGAAACAACGAA	0.393													0	0	0	1	0	16	55										A	63510308	G	A	63510308	2	1	83	1	0	0	0	0	0	0	0	1	13464	1165	41	1		1	RNF180	5	63510308	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	13419169	63510308	117404952	150	24994										
AP3B1	8546	broad.mit.edu	37	chr5	77409639	77409639	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttctaggcctgactcccgtCcactctcactgtcctgctca	6	17	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:77409639C>G	uc003kfj.2	-	19	2311	c.2186G>C	c.(2185-2187)GGA>GCA	p.G729A		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	729	Glu/Ser-rich.				endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TGACTCCCGTCCACTCTCACT	0.453									Hermansky-Pudlak_syndrome				0	0	0	1	0	10	92										G	77409639	C	G	77409639	3	3	83	1	0	0	0	0	1	0	0	0	744	855	30	1	1134	1	AP3B1	5	77409639	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	13899331	77409639	103505621	151	24995										
PAPD4	167153	broad.mit.edu	37	chr5	78944941	78944941	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agaagtgggcaagtcaccatCagataaatgatgccagtcgt	11	8	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:78944941C>T	uc010jae.1	+	11	1373	c.955C>T	c.(955-957)CAG>TAG	p.Q319*	PAPD4_uc003kgb.2_Nonsense_Mutation_p.Q319*|PAPD4_uc010jaf.1_Nonsense_Mutation_p.Q319*|PAPD4_uc003kga.2_Nonsense_Mutation_p.Q315*|PAPD4_uc003kfz.2_Intron	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	319					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		AAGTCACCATCAGATAAATGA	0.358													0	0	0	1	0	10	26										T	78944941	C	T	78944941	4	4	83	1	0	0	0	0	0	1	0	0	11424	827	29	1	989	1	PAPD4	5	78944941	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1535302	78944941	101970319	152	24996										
ZFYVE16	9765	broad.mit.edu	37	chr5	79733262	79733262	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgctttgactcgacaaagttCcaaaatgtttcatgccaaag	7	9	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:79733262C>A	uc003kgr.3	+	4	1060	c.758C>A	c.(757-759)TCC>TAC	p.S253Y	ZFYVE16_uc010jak.1_Missense_Mutation_p.S253Y|ZFYVE16_uc003kgp.2_Missense_Mutation_p.S253Y|ZFYVE16_uc003kgq.3_Missense_Mutation_p.S253Y|ZFYVE16_uc003kgs.3_Missense_Mutation_p.S253Y	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	253					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CGACAAAGTTCCAAAATGTTT	0.343													1	0	2.27525e-19	1	2.39063e-19	26	67										A	79733262	C	A	79733262	3	1	83	1	0	0	0	0	1	0	0	0	17661	855	30	3	764	3	ZFYVE16	5	79733262	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	788321	79733262	101181998	153	24997										
ZFYVE16	9765	broad.mit.edu	37	chr5	79734015	79734015	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggttttattaatactttttCaagcaatgatatggatgggc	9	4	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:79734015C>G	uc003kgr.3	+	4	1813	c.1511C>G	c.(1510-1512)TCA>TGA	p.S504*	ZFYVE16_uc010jak.1_Nonsense_Mutation_p.S504*|ZFYVE16_uc003kgp.2_Nonsense_Mutation_p.S504*|ZFYVE16_uc003kgq.3_Nonsense_Mutation_p.S504*|ZFYVE16_uc003kgs.3_Nonsense_Mutation_p.S504*	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	504					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AATACTTTTTCAAGCAATGAT	0.403													0	0	0	1	0	26	53										G	79734015	C	G	79734015	4	3	83	1	0	0	0	0	0	1	0	0	17661	838	29	1	1517	1	ZFYVE16	5	79734015	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	753	79734015	101181245	154	24998										
VCAN	1462	broad.mit.edu	37	chr5	82789485	82789485	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agagcagctctttgctgcctAtgaagatggatttgagcagt	12	7	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:82789485A>G	uc003kii.3	+	4	922	c.566A>G	c.(565-567)TAT>TGT	p.Y189C	VCAN_uc003kij.3_Missense_Mutation_p.Y189C|VCAN_uc010jau.2_Missense_Mutation_p.Y189C|VCAN_uc003kik.3_Missense_Mutation_p.Y189C|VCAN_uc003kih.3_Missense_Mutation_p.Y189C	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	189	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTTGCTGCCTATGAAGATGGA	0.522													0	0	0	1	0	30	79										G	82789485	A	G	82789485	3	3	83	1	0	0	0	0	1	0	0	0	17135	449	16	5	576	5	VCAN	5	82789485	Missense_Mutation	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	3055470	82789485	98125775	155	24999										
EDIL3	10085	broad.mit.edu	37	chr5	83239311	83239311	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accaggaccaaggaaggattCttatgtgtcgtgcatagatg	12	7	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:83239311C>T	uc003kio.1	-	11	1789	c.1370G>A	c.(1369-1371)AGA>AAA	p.R457K	EDIL3_uc003kip.1_Missense_Mutation_p.R447K	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	457	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AGGAAGGATTCTTATGTGTCG	0.468													0	0	0	1	0	11	42										T	83239311	C	T	83239311	3	4	83	1	0	0	0	0	1	0	0	0	4915	913	32	1	76	1	EDIL3	5	83239311	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	449826	83239311	97675949	156	25000										
SPATA9	83890	broad.mit.edu	37	chr5	95011140	95011140	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgttatataggggttgcctCggcgcattaacttccctcag	10	10	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:95011140C>T	uc003klj.1	-	3	510	c.354G>A	c.(352-354)CCG>CCA	p.P118P	SPATA9_uc010jbh.1_RNA|SPATA9_uc003klh.1_RNA|SPATA9_uc003kli.1_Intron	NM_031952	NP_114158	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	118					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane					0		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		GGGGTTGCCTCGGCGCATTAA	0.408													0	0	0	1	0	20	40										T	95011140	C	T	95011140	2	4	83	1	0	0	0	0	0	0	0	1	15015	871	31	1		1	SPATA9	5	95011140	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	11771829	95011140	85904120	157	25001										
RGMB	285704	broad.mit.edu	37	chr5	98129101	98129101	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgaacggctgccccctgagtGaacgcatcgatgacgggcag	14	12	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:98129101G>A	uc003knc.2	+	5	1483	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K		NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	320					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		CCCCCTGAGTGAACGCATCGA	0.637													0	0	0	1	0	4	20										A	98129101	G	A	98129101	3	1	83	1	0	0	0	0	1	0	0	0	13281	1291	45	1	1095	1	RGMB	5	98129101	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3117961	98129101	82786159	158	25002										
MARCH3	115123	broad.mit.edu	37	chr5	126214081	126214081	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgctgggggccagggtttctCagccactgccaggtaaaggg	16	10	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:126214081C>T	uc003kuf.2	-	4	854	c.399G>A	c.(397-399)CTG>CTA	p.L133L		NM_178450	NP_848545	Q86UD3	MARH3_HUMAN	membrane-associated ring finger (C3HC4) 3	133					endocytosis	cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosome	ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.074)|OV - Ovarian serous cystadenocarcinoma(64;0.0793)		CAGGGTTTCTCAGCCACTGCC	0.547													0	0	0	1	0	4	10										T	126214081	C	T	126214081	2	4	83	1	0	0	0	0	0	0	0	1	9302	813	29	1		1	MARCH3	5	126214081	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	28084980	126214081	54701179	159	25003										
AFF4	27125	broad.mit.edu	37	chr5	132270153	132270153	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttgatgttccttgctatggtGatcattcccatgagacctgg	10	9	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:132270153G>A	uc003kyd.2	-	3	1012	c.604C>T	c.(604-606)CAC>TAC	p.H202Y	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.H202Y|AFF4_uc003kyf.3_Missense_Mutation_p.H202Y	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	202	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGCTATGGTGATCATTCCCA	0.488													0	0	0	1	0	21	73										A	132270153	G	A	132270153	3	1	83	1	0	0	0	0	1	0	0	0	359	1290	45	1	2963	1	AFF4	5	132270153	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6056072	132270153	48645107	160	25004										
PCDHB8	56128	broad.mit.edu	37	chr5	140558545	140558545	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctaaagaaacaacttgatttCgaaaaatttcagtcctatga	5	7	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:140558545C>T	uc011dai.1	+	1	1116	c.930C>T	c.(928-930)TTC>TTT	p.F310F	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	310	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTTGATTTCGAAAAATTTC	0.383													0	0	0	1	0	32	275										T	140558545	C	T	140558545	2	4	83	1	0	0	0	0	0	0	0	1	11548	883	31	1		1	PCDHB8	5	140558545	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	8288392	140558545	40356715	161	25005										
SLC25A2	83884	broad.mit.edu	37	chr5	140682702	140682702	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caataaatcctgcctgtttcCcatacatggaaagaacttga	6	10	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:140682702C>T	uc003ljf.2	-	1	911	c.731G>A	c.(730-732)GGG>GAG	p.G244E		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	244	Helical; Name=6; (Potential).|Solcar 3.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TGCCTGTTTCCCATACATGGA	0.403													0	0	0	1	0	23	51										T	140682702	C	T	140682702	3	4	83	1	0	0	0	0	1	0	0	0	14482	623	22	2	178	2	SLC25A2	5	140682702	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	124157	140682702	40232558	162	25006										
KCTD16	57528	broad.mit.edu	37	chr5	143853407	143853407	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtgacacgccagaccaacatCcagactctggaccgtcccat	8	16	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:143853407C>G	uc003lnm.1	+	4	1646	c.1017C>G	c.(1015-1017)ATC>ATG	p.I339M	KCTD16_uc003lnn.1_Missense_Mutation_p.I339M	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	339						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AGACCAACATCCAGACTCTGG	0.582													0	0	0	1	0	19	63										G	143853407	C	G	143853407	3	3	83	1	0	0	0	0	1	0	0	0	8103	845	30	1	1023	1	KCTD16	5	143853407	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3170705	143853407	37061853	163	25007										
FAT2	2196	broad.mit.edu	37	chr5	150924410	150924410	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccaagtcctcatcagtggcaGatacctgaaagaggacatcc	9	12	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:150924410G>T	uc003lue.3	-	9	6291	c.6278C>A	c.(6277-6279)TCT>TAT	p.S2093Y	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2093	Extracellular (Potential).|Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCAGTGGCAGATACCTGAAA	0.443													1	0	8.16277e-20	1	8.59414e-20	36	100										T	150924410	G	T	150924410	3	4	83	1	0	0	0	0	1	0	0	0	5690	942	33	3	6831	3	FAT2	5	150924410	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	7071003	150924410	29990850	164	25008										
THG1L	54974	broad.mit.edu	37	chr5	157161651	157161651	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttattggcgggattactttGaggaccagccccttctgtat	10	9	1	1	rs78234336		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:157161651G>A	uc003lxd.2	+	3	562	c.436G>A	c.(436-438)GAG>AAG	p.E146K	THG1L_uc011ddu.1_Intron	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45	146					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGATTACTTTGAGGACCAGCC	0.502													0	0	0	1	0	25	87										A	157161651	G	A	157161651	3	1	83	1	0	0	0	0	1	0	0	0	15858	1291	45	1	446	1	THG1L	5	157161651	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6237241	157161651	23753609	165	25009										
ODZ2	57451	broad.mit.edu	37	chr5	167689355	167689355	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caaggacacccactactttgTgaagattggctcagccgatg	10	11	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:167689355T>C	uc010jjd.2	+	29	7838	c.7838T>C	c.(7837-7839)GTG>GCG	p.V2613A	ODZ2_uc003lzr.3_Missense_Mutation_p.V2383A|ODZ2_uc003lzt.3_Missense_Mutation_p.V1986A|ODZ2_uc010jje.2_Missense_Mutation_p.V1877A	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACTACTTTGTGAAGATTGGC	0.592													0	0	0	1	0	5	10										C	167689355	T	C	167689355	3	2	83	1	0	0	0	0	1	0	0	0	10835	1696	59	5	7952	5	ODZ2	5	167689355	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	10527704	167689355	13225905	166	25010										
UIMC1	51720	broad.mit.edu	37	chr5	176396246	176396246	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcagcctcgtttccctgactGatatgtgagcctttaaacag	8	11	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:176396246G>C	uc011dfp.1	-	6	677	c.510C>G	c.(508-510)ATC>ATG	p.I170M	UIMC1_uc003mfc.1_Missense_Mutation_p.I47M|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mff.1_Intron	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	170	Necessary for interaction with NR6A1 N- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCCTGACTGATATGTGAGC	0.483													0	0	0	1	0	9	107										C	176396246	G	C	176396246	3	2	83	1	0	0	0	0	1	0	0	0	16968	1280	45	1	1689	1	UIMC1	5	176396246	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8706891	176396246	4519014	167	25011										
AGXT2L2	85007	broad.mit.edu	37	chr5	177658513	177658513	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gatcctcgggaaaaaagagtCtgcaggaagagctgtgggga	16	6	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:177658513C>G	uc003miz.2	-	2	323	c.71G>C	c.(70-72)AGA>ACA	p.R24T	AGXT2L2_uc003mjc.2_5'UTR|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_5'UTR	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	24						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AAAAAAGAGTCTGCAGGAAGA	0.547													0	0	0	1	0	32	94										G	177658513	C	G	177658513	3	3	83	1	0	0	0	0	1	0	0	0	407	913	32	1	1325	1	AGXT2L2	5	177658513	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1262267	177658513	3256747	168	25012										
C5orf45	51149	broad.mit.edu	37	chr5	179264605	179264605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgggcctgctgaggccttctCttgaggcctgtgctctgggg	16	11	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:179264605C>G	uc003mla.2	-	7	862	c.818G>C	c.(817-819)AGA>ACA	p.R273T	SQSTM1_uc011dgr.1_3'UTR|SQSTM1_uc011dgs.1_3'UTR|SQSTM1_uc003mkw.3_3'UTR|SQSTM1_uc003mkx.2_3'UTR|C5orf45_uc003mky.2_Intron|C5orf45_uc011dgt.1_Intron|C5orf45_uc011dgu.1_Intron|C5orf45_uc003mlc.2_Missense_Mutation_p.R218T|C5orf45_uc003mlb.2_Missense_Mutation_p.R139T	NM_016175	NP_057259	Q6NTE8	CE045_HUMAN	hypothetical protein LOC51149 isoform 1	273											0						GAGGCCTTCTCTTGAGGCCTG	0.632													0	0	0	1	0	31	64										G	179264605	C	G	179264605	3	3	83	1	0	0	0	0	1	0	0	0	2304	913	32	1	217	1	C5orf45	5	179264605	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1606092	179264605	1650655	169	25013										
C6orf145	221749	broad.mit.edu	37	chr6	3723966	3723966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gggaaactcactgccattctCaaatctgaaattagagaaac	7	9	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:3723966C>G	uc003mvt.2	-	5	1064	c.583G>C	c.(583-585)GAG>CAG	p.E195Q		NM_183373	NP_899229	Q5TGL8	CF145_HUMAN	hypothetical protein LOC221749	195					cell communication		phosphatidylinositol binding			breast(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				CTGCCATTCTCAAATCTGAAA	0.537													0	0	0	1	0	16	41										G	3723966	C	G	3723966	3	3	83	1	0	0	0	0	1	0	0	0	2334	835	29	1	116	1	C6orf145	6	3723966	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		3723966	167391101	170	25014										
KDM1B	221656	broad.mit.edu	37	chr6	18160153	18160153	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actccacgggggaggacaaaGaaaaaagcatcttttgatca	10	8	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:18160153G>C	uc003ncn.1	+	3	268	c.27G>C	c.(25-27)AAG>AAC	p.K9N		NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	9					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						GGAGGACAAAGAAAAAAGCAT	0.333													0	0	0	1	0	6	22										C	18160153	G	C	18160153	3	2	83	1	0	0	0	0	1	0	0	0	8123	933	33	1	29	1	KDM1B	6	18160153	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	14436187	18160153	152954914	171	25015										
HIST1H2AD	3013	broad.mit.edu	37	chr6	26199400	26199400	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acgcggcccacagggaactgGagtccggcccgcgaagagcg	16	14	0	1	rs150465023		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:26199400G>C	uc003ngw.2	-	1	72	c.72C>G	c.(70-72)CTC>CTG	p.L24L	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	24					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				CAGGGAACTGGAGTCCGGCCC	0.612													0	0	0	1	0	17	31										C	26199400	G	C	26199400	2	2	83	1	0	0	0	0	0	0	0	1	7131	1161	41	1		1	HIST1H2AD	6	26199400	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8039247	26199400	144915667	172	25016										
ZNF184	7738	broad.mit.edu	37	chr6	27419547	27419547	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgctgtgtaaggtgtatgttCtggttgaatgctctcccaca	11	8	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:27419547C>T	uc003njj.2	-	5	2602	c.1791G>A	c.(1789-1791)CAG>CAA	p.Q597Q	ZNF184_uc010jqv.2_Silent_p.Q597Q|ZNF184_uc003nji.2_Silent_p.Q597Q	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	597	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGTGTATGTTCTGGTTGAATG	0.433													0	0	0	1	0	29	69										T	27419547	C	T	27419547	2	4	83	1	0	0	0	0	0	0	0	1	17748	912	32	1		1	ZNF184	6	27419547	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1220147	27419547	143695520	173	25017										
ZNF323	64288	broad.mit.edu	37	chr6	28295307	28295307	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgtccatgttcatggtctgGagcctgaaggcaggtaggca	14	8	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:28295307G>A	uc003nla.2	-	3	785	c.385C>T	c.(385-387)CCA>TCA	p.P129S	ZNF323_uc003nld.2_Missense_Mutation_p.P129S|ZNF323_uc010jra.2_Missense_Mutation_p.P129S|ZNF323_uc003nlb.2_5'UTR|ZNF323_uc010jrb.2_5'UTR|ZNF323_uc003nlc.2_Missense_Mutation_p.P129S	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	129					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCATGGTCTGGAGCCTGAAGG	0.423													0	0	0	1	0	23	66										A	28295307	G	A	28295307	3	1	83	1	0	0	0	0	1	0	0	0	17840	1174	41	1	843	1	ZNF323	6	28295307	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	875760	28295307	142819760	174	25018										
HLA-E	3133	broad.mit.edu	37	chr6	30458229	30458229	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accagagagcctacctggaaGacacatgcgtggagtggctc	13	11	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:30458229G>A	uc003nqg.2	+	3	585	c.547G>A	c.(547-549)GAC>AAC	p.D183N	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Missense_Mutation_p.D224N	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	183	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						CTACCTGGAAGACACATGCGT	0.597													0	0	0	1	0	20	42										A	30458229	G	A	30458229	3	1	83	1	0	0	0	0	1	0	0	0	7210	942	33	1	557	1	HLA-E	6	30458229	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2162922	30458229	140656838	175	25019										
BAT2	7916	broad.mit.edu	37	chr6	31599733	31599733	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggagcgagggttcagagtatGaggaaatccccaagcggcgc	16	9	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:31599733G>A	uc003nvb.3	+	16	3532	c.3283G>A	c.(3283-3285)GAG>AAG	p.E1095K	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.E1095K	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1095	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TTCAGAGTATGAGGAAATCCC	0.637													0	0	0	1	0	5	25										A	31599733	G	A	31599733	3	1	83	1	0	0	0	0	1	0	0	0	1319	1291	45	1	3341	1	BAT2	6	31599733	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1141504	31599733	139515334	176	25020										
TNXB	7148	broad.mit.edu	37	chr6	32029210	32029210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggacaccgggcccacgcgccGcccctcgtggaggccataca	13	18	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32029210G>A	uc003nzl.2	-	21	7658	c.7456C>T	c.(7456-7458)CGG>TGG	p.R2486W		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2546	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCCACGCGCCGCCCCTCGTGG	0.647													0	0	0	1	0	37	84										A	32029210	G	A	32029210	3	1	83	1	0	0	0	0	1	0	0	0	16343	1086	38	2	7353	2	TNXB	6	32029210	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	429477	32029210	139085857	177	25021										
TNXB	7148	broad.mit.edu	37	chr6	32035515	32035515	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggtgcatcttgtacttgcgcCcaggctccaggccccccacg	11	17	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32035515C>G	uc003nzl.2	-	18	6669	c.6467G>C	c.(6466-6468)GGG>GCG	p.G2156A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2228	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTACTTGCGCCCAGGCTCCAG	0.677													0	0	0	1	0	15	49										G	32035515	C	G	32035515	3	3	83	1	0	0	0	0	1	0	0	0	16343	623	22	4	8354	4	TNXB	6	32035515	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6305	32035515	139079552	178	25022										
ATF6B	1388	broad.mit.edu	37	chr6	32085730	32085730	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccctgaactggctcttgctCtgagaaccccagcaagtgtc	9	14	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32085730C>T	uc003nzn.2	-	12	1363	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_Missense_Mutation_p.E17K|ATF6B_uc003nzo.2_Missense_Mutation_p.E441K|ATF6B_uc003nzp.1_Missense_Mutation_p.E133K	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	444	Lumenal (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCTCTTGCTCTGAGAACCCC	0.602													0	0	0	1	0	13	19										T	32085730	C	T	32085730	3	4	83	1	0	0	0	0	1	0	0	0	1085	922	32	1	809	1	ATF6B	6	32085730	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	50215	32085730	139029337	179	25023										
ITPR3	3710	broad.mit.edu	37	chr6	33648329	33648329	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gccatccctctctcctgcctCaggtctgcagcaagcgtgag	10	16	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:33648329C>G	uc011drk.1	+	33	4567	c.4348C>G	c.(4348-4350)CGG>GGG	p.R1450G		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1450	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCTCCTGCCTCAGGTCTGCAG	0.647													0	0	0	1	0	14	37										G	33648329	C	G	33648329	3	3	83	1	0	0	0	0	1	0	0	0	7922	827	29	1	4478	1	ITPR3	6	33648329	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1562599	33648329	137466738	180	25024										
ANKS1A	23294	broad.mit.edu	37	chr6	34985672	34985672	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccactagcaaacccaaagctGaactcaaactcagccgcagc	6	16	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:34985672G>A	uc003ojx.3	+	11	1988	c.1846G>A	c.(1846-1848)GAA>AAA	p.E616K	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.E156K|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	616						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACCCAAAGCTGAACTCAAACT	0.582													0	0	0	1	0	44	124										A	34985672	G	A	34985672	3	1	83	1	0	0	0	0	1	0	0	0	688	1291	45	1	1888	1	ANKS1A	6	34985672	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1337343	34985672	136129395	181	25025										
CDKN1A	1026	broad.mit.edu	37	chr6	36652198	36652199	+	Frame_Shift_Ins	INS	-	-	G													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgctgcaggggacagcagaINSggaagaccatgtggacctgt							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:36652198_36652199insG	uc003omm.3	+	2	442_443	c.320_321insG	c.(319-321)GAGfs	p.E107fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E141fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E107fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E107fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	107					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GGGACAGCAGAGGAAGACCATG	0.653									Multiple_Endocrine_Neoplasia_type_1									8	19	---	---								G	36652199	-	G	36652198	7	5	83	1	0	1	1	0	0	0	0	0	3158	304	11	0	322	0	CDKN1A	6	36652198	Frame_Shift_Ins	INS	-	TCGA-FD-A3SO-01A-11D-A22Z-08	1666526	36652198	134462869	182	25026										
CD2AP	23607	broad.mit.edu	37	chr6	47544302	47544302	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacccaaaactcagagtgtgGagataacaaaaacagatacc	8	9	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:47544302G>C	uc003oyw.2	+	7	1228	c.772G>C	c.(772-774)GAG>CAG	p.E258Q		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	258					cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TCAGAGTGTGGAGATAACAAA	0.303													0	0	0	1	0	21	76										C	47544302	G	C	47544302	3	2	83	1	0	0	0	0	1	0	0	0	2994	1175	41	1	798	1	CD2AP	6	47544302	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10892104	47544302	123570765	183	25027										
CD2AP	23607	broad.mit.edu	37	chr6	47544789	47544789	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttgcctatgaaggtactaatGaagatgaacttacttttaaa	7	5	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:47544789G>T	uc003oyw.2	+	8	1309	c.853G>T	c.(853-855)GAA>TAA	p.E285*		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	285	SH3 3.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AGGTACTAATGAAGATGAACT	0.269													1	0	3.83957e-06	1	3.91515e-06	11	113										T	47544789	G	T	47544789	4	4	83	1	0	0	0	0	0	1	0	0	2994	1291	45	3	883	3	CD2AP	6	47544789	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	487	47544789	123570278	184	25028										
PKHD1	5314	broad.mit.edu	37	chr6	51497406	51497406	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caacagcacaccagacagctCagagccagccatgaggccac	9	16	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:51497406C>T	uc003pah.1	-	65	11898	c.11622G>A	c.(11620-11622)CTG>CTA	p.L3874L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3874	Helical; (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCAGACAGCTCAGAGCCAGCC	0.438													0	0	0	1	0	14	43										T	51497406	C	T	51497406	2	4	83	1	0	0	0	0	0	0	0	1	11971	813	29	1		1	PKHD1	6	51497406	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3952617	51497406	119617661	185	25029										
ZNF451	26036	broad.mit.edu	37	chr6	57012191	57012191	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accatgtctattaaagaatcTagctcactggagtgcattgc	8	9	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:57012191T>C	uc003pdm.1	+	10	1532	c.1308T>C	c.(1306-1308)TCT>TCC	p.S436S	ZNF451_uc003pdl.2_Silent_p.S436S|ZNF451_uc003pdn.1_Silent_p.S436S|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Silent_p.S436S	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTAAAGAATCTAGCTCACTGG	0.353													0	0	0	1	0	18	56										C	57012191	T	C	57012191	2	2	83	1	0	0	0	0	0	0	0	1	17919	1509	53	5		5	ZNF451	6	57012191	Silent	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	5514785	57012191	114102876	186	25030										
PHF3	23469	broad.mit.edu	37	chr6	64395407	64395407	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttcaagcccttaactcattCtttgagtgataagtcacacg	6	10	4	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:64395407C>G	uc003pep.1	+	3	1810	c.1784C>G	c.(1783-1785)TCT>TGT	p.S595C	PHF3_uc010kaf.1_Missense_Mutation_p.S595C|PHF3_uc003pem.2_Missense_Mutation_p.S548C|PHF3_uc010kag.1_Missense_Mutation_p.S507C|PHF3_uc010kah.1_Missense_Mutation_p.S409C|PHF3_uc003pen.2_Missense_Mutation_p.S507C|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.S595C	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	595					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTAACTCATTCTTTGAGTGAT	0.378													0	0	0	1	0	16	58										G	64395407	C	G	64395407	3	3	83	1	0	0	0	0	1	0	0	0	11836	913	32	1	1794	1	PHF3	6	64395407	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7383216	64395407	106719660	187	25031										
BAI3	577	broad.mit.edu	37	chr6	69640534	69640534	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gggtccctcaggaacaagctGatgctgctaaatttatggca	11	9	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:69640534G>A	uc003pev.3	+	4	1289	c.841G>A	c.(841-843)GAT>AAT	p.D281N	BAI3_uc010kak.2_Missense_Mutation_p.D281N	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	281	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GGAACAAGCTGATGCTGCTAA	0.333													0	0	0	1	0	10	31										A	69640534	G	A	69640534	3	1	83	1	0	0	0	0	1	0	0	0	1300	1290	45	1	847	1	BAI3	6	69640534	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	5245127	69640534	101474533	188	25032										
B3GAT2	135152	broad.mit.edu	37	chr6	71665851	71665851	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggcgggtcagctccgctttCtgcaccgggcggctgtaggt	16	12	2	0	rs9446312		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:71665851C>G	uc003pfv.2	-	1	938	c.282G>C	c.(280-282)CAG>CAC	p.Q94H	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.Q94H	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	94	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GCTCCGCTTTCTGCACCGGGC	0.697													0	0	0	1	0	18	32										G	71665851	C	G	71665851	3	3	83	1	0	0	0	0	1	0	0	0	1254	912	32	1	705	1	B3GAT2	6	71665851	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2025317	71665851	99449216	189	25033										
ANKRD6	22881	broad.mit.edu	37	chr6	90333717	90333717	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	catccccacccccaccccatGagttcagggcgtatcagctc	7	19	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:90333717G>C	uc003pni.3	+	12	1500	c.1159G>C	c.(1159-1161)GAG>CAG	p.E387Q	ANKRD6_uc003pne.3_Missense_Mutation_p.E387Q|ANKRD6_uc003pnf.3_Missense_Mutation_p.E352Q|ANKRD6_uc011dzy.1_Missense_Mutation_p.E387Q|ANKRD6_uc010kcd.2_Missense_Mutation_p.E328Q|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_5'UTR|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	387							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CCCACCCCATGAGTTCAGGGC	0.537													0	0	0	1	0	6	17										C	90333717	G	C	90333717	3	2	83	1	0	0	0	0	1	0	0	0	685	1291	45	1	1201	1	ANKRD6	6	90333717	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	18667866	90333717	80781350	190	25034										
RFX6	222546	broad.mit.edu	37	chr6	117243302	117243302	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttggatactgtggtagaacaGagagttattaaggtactttt	11	3	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:117243302G>C	uc003pxm.2	+	13	1488	c.1425G>C	c.(1423-1425)CAG>CAC	p.Q475H		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	475					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TGGTAGAACAGAGAGTTATTA	0.378													0	0	0	1	0	19	61										C	117243302	G	C	117243302	3	2	83	1	0	0	0	0	1	0	0	0	13267	933	33	1	1475	1	RFX6	6	117243302	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	26909585	117243302	53871765	191	25035										
RFX6	222546	broad.mit.edu	37	chr6	117252568	117252568	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cttccaaccagtatccagctCaagaaaccctggactcccat	5	16	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:117252568C>G	uc003pxm.2	+	19	2749	c.2686C>G	c.(2686-2688)CAA>GAA	p.Q896E		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	896					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GTATCCAGCTCAAGAAACCCT	0.448													0	0	0	1	0	26	66										G	117252568	C	G	117252568	3	3	83	1	0	0	0	0	1	0	0	0	13267	827	29	1	2760	1	RFX6	6	117252568	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	9266	117252568	53862499	192	25036										
THEMIS	387357	broad.mit.edu	37	chr6	128222209	128222209	+	Translation_Start_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggaatgtcacactacagccaGagtggggtggagtagctcta	14	8	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:128222209G>T	uc003qbi.2	-	2	188	c.-131C>A	c.(-133--129)CTCTG>CTATG		THEMIS_uc011ebt.1_Translation_Start_Site|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform						negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						ACTACAGCCAGAGTGGGGTGG	0.507													1	0	0.004672	1	0.00469922	3	18										T	128222209	G	T	128222209	1	4	83	1	0	0	0	0	0	0	0	0	15857	957	33	3		3	THEMIS	6	128222209	Translation_Start_Site	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10969641	128222209	42892858	193	25037										
ECT2L	345930	broad.mit.edu	37	chr6	139206926	139206926	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accgtggggacttgaccactGcaattgaccaaatcaaaaaa	8	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:139206926G>A	uc003qif.1	+	16	2321	c.2218G>A	c.(2218-2220)GCA>ACA	p.A740T	ECT2L_uc011edq.1_Intron	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	740	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CTTGACCACTGCAATTGACCA	0.418													0	0	0	1	0	25	53										A	139206926	G	A	139206926	3	1	83	1	0	0	0	0	1	0	0	0	4902	1319	46	2	2280	2	ECT2L	6	139206926	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10984717	139206926	31908141	194	25038										
NMBR	4829	broad.mit.edu	37	chr6	142409491	142409491	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actcgtcgaagaagtagcgcGaggcgtccaccgggacgcag	15	12	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:142409491G>C	uc003qiu.2	-	1	446	c.305C>G	c.(304-306)TCG>TGG	p.S102W		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	102	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GAAGTAGCGCGAGGCGTCCAC	0.592													0	0	0	1	0	15	23										C	142409491	G	C	142409491	3	2	83	1	0	0	0	0	1	0	0	0	10487	1059	37	1	879	1	NMBR	6	142409491	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3202565	142409491	28705576	195	25039										
NUP43	348995	broad.mit.edu	37	chr6	150059906	150059906	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agcatggagtgtactactatCtgcattgtctaaaaatttaa	7	6	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:150059906C>G	uc003qmz.2	-	5	568	c.511G>C	c.(511-513)GAT>CAT	p.D171H	NUP43_uc003qmx.3_5'Flank|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Intron	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	171	WD 4.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		GTACTACTATCTGCATTGTCT	0.333													0	0	0	1	0	25	85										G	150059906	C	G	150059906	3	3	83	1	0	0	0	0	1	0	0	0	10765	913	32	1	647	1	NUP43	6	150059906	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7650415	150059906	21055161	196	25040										
AKAP12	9590	broad.mit.edu	37	chr6	151671704	151671704	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacaaagagacggggacagaCgggatccttgctggttccca	14	10	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:151671704C>T	uc011eep.1	+	4	2418	c.2178C>T	c.(2176-2178)GAC>GAT	p.D726D	AKAP12_uc003qoe.2_Silent_p.D726D|AKAP12_uc003qof.2_Silent_p.D628D|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.D621D	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	726					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CGGGGACAGACGGGATCCTTG	0.587													0	0	0	1	0	40	101										T	151671704	C	T	151671704	2	4	83	1	0	0	0	0	0	0	0	1	448	535	19	2		2	AKAP12	6	151671704	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1611798	151671704	19443363	197	25041										
SYNE1	23345	broad.mit.edu	37	chr6	152477104	152477104	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caccgccggtccaggtttctCgtagcctgctgtatagagtc	11	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:152477104C>T	uc010kiw.2	-	132	24521	c.23919G>A	c.(23917-23919)ACG>ACA	p.T7973T	SYNE1_uc010kiv.2_Silent_p.T2497T|SYNE1_uc003qos.3_Silent_p.T2497T|SYNE1_uc003qot.3_Silent_p.T7902T|SYNE1_uc003qou.3_Silent_p.T7973T|SYNE1_uc003qop.3_Silent_p.T135T|SYNE1_uc011eez.1_Silent_p.T175T|SYNE1_uc003qoq.3_Silent_p.T175T|SYNE1_uc003qor.3_Silent_p.T873T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7973	Spectrin 28.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCAGGTTTCTCGTAGCCTGCT	0.532										HNSCC(10;0.0054)			0	0	0	1	0	14	57										T	152477104	C	T	152477104	2	4	83	1	0	0	0	0	0	0	0	1	15442	871	31	1		1	SYNE1	6	152477104	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	805400	152477104	18637963	198	25042										
THBS2	7058	broad.mit.edu	37	chr6	169648730	169648730	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaccacatgccgggtgccgtCaatccagtaggtgagatcca	12	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:169648730C>T	uc003qwt.2	-	4	639	c.391G>A	c.(391-393)GAC>AAC	p.D131N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	131	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CGGGTGCCGTCAATCCAGTAG	0.652													0	0	0	1	0	27	60										T	169648730	C	T	169648730	3	4	83	1	0	0	0	0	1	0	0	0	15851	826	29	1	3207	1	THBS2	6	169648730	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	17171626	169648730	1466337	199	25043										
STK31	56164	broad.mit.edu	37	chr7	23810669	23810669	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taatttcaaatacatatagtCaagtactgcaaaagattcat	4	6	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:23810669C>T	uc003sws.3	+	14	1826	c.1759C>T	c.(1759-1761)CAA>TAA	p.Q587*	STK31_uc003swt.3_Nonsense_Mutation_p.Q564*|STK31_uc011jze.1_Nonsense_Mutation_p.Q587*|STK31_uc010kuq.2_Nonsense_Mutation_p.Q564*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	587							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TACATATAGTCAAGTACTGCA	0.348													0	0	0	1	0	30	96										T	23810669	C	T	23810669	4	4	83	1	0	0	0	0	0	1	0	0	15295	827	29	1	1813	1	STK31	7	23810669	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		23810669	135327994	200	25044										
GHRHR	2692	broad.mit.edu	37	chr7	31018736	31018736	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcttccttgtccctggaggtGaggactgagatctcacggaa	12	10	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:31018736G>A	uc003tbx.2	+	13	1197	c.1149G>A	c.(1147-1149)GTG>GTA	p.V383V	GHRHR_uc003tby.2_Silent_p.V319V|GHRHR_uc003tbz.2_Missense_Mutation_p.E150K	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	383	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CCCTGGAGGTGAGGACTGAGA	0.592													0	0	0	1	0	10	46										A	31018736	G	A	31018736	2	1	83	1	0	0	0	0	0	0	0	1	6373	1277	45	1		1	GHRHR	7	31018736	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	7208067	31018736	128119927	201	25045										
INHBA	3624	broad.mit.edu	37	chr7	41739721	41739721	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgaagctttctgatcgcgttCagaagcgccgccttgggtac	12	11	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:41739721C>T	uc003thq.2	-	1	487	c.252G>A	c.(250-252)CTG>CTA	p.L84L	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Silent_p.L84L|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	84					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						TGATCGCGTTCAGAAGCGCCG	0.517										TSP Lung(11;0.080)			0	0	0	1	0	135	329										T	41739721	C	T	41739721	2	4	83	1	0	0	0	0	0	0	0	1	7741	813	29	1		1	INHBA	7	41739721	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10720985	41739721	117398942	202	25046										
CALN1	83698	broad.mit.edu	37	chr7	71571273	71571273	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccagaacccgaaaggcctctCggatttctacaatggaaaag	9	11	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:71571273C>T	uc003twa.3	-	3	652	c.125G>A	c.(124-126)CGA>CAA	p.R42Q	CALN1_uc003twb.3_Missense_Mutation_p.R84Q|CALN1_uc003twc.3_Missense_Mutation_p.R42Q	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	42	EF-hand 1.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				AAAGGCCTCTCGGATTTCTAC	0.527													0	0	0	1	0	17	29										T	71571273	C	T	71571273	3	4	83	1	0	0	0	0	1	0	0	0	2591	884	31	1	550	1	CALN1	7	71571273	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	29831552	71571273	87567390	203	25047										
GTF2I	2969	broad.mit.edu	37	chr7	74119540	74119540	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgacaggtcaatactatctCcaggtggaaggtaaaaccta	9	9	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:74119540C>G	uc003uau.2	+	7	1001	c.631C>G	c.(631-633)CCA>GCA	p.P211A	GTF2I_uc003uat.2_Missense_Mutation_p.P211A|GTF2I_uc003uav.2_Missense_Mutation_p.P211A|GTF2I_uc003uaw.2_Missense_Mutation_p.P211A|GTF2I_uc003uay.2_Missense_Mutation_p.P211A|GTF2I_uc003uax.2_Missense_Mutation_p.P211A|uc003uaz.2_Intron	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	211					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						AATACTATCTCCAGGTGGAAG	0.318													0	0	0	1	0	9	46										G	74119540	C	G	74119540	3	3	83	1	0	0	0	0	1	0	0	0	6867	855	30	1	653	1	GTF2I	7	74119540	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2548267	74119540	85019123	204	25048										
SEMA3A	10371	broad.mit.edu	37	chr7	83823834	83823834	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggcacattgttcttcccattCtgatagtttgctcttgctgt	8	10	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:83823834C>T	uc003uhz.2	-	1	384	c.69G>A	c.(67-69)CAG>CAA	p.Q23Q		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	23					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TCTTCCCATTCTGATAGTTTG	0.418													0	0	0	1	0	37	104										T	83823834	C	T	83823834	2	4	83	1	0	0	0	0	0	0	0	1	14024	912	32	1		1	SEMA3A	7	83823834	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	9704294	83823834	75314829	205	25049										
ABCB1	5243	broad.mit.edu	37	chr7	87196174	87196174	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcctgtcgcattatagcatGaaaaaactgttttctaattt	5	8	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:87196174G>A	uc003uiz.1	-	7	875	c.457C>T	c.(457-459)CAT>TAT	p.H153Y	ABCB1_uc011khc.1_Intron	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	153	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATTATAGCATGAAAAAACTGT	0.418													0	0	0	1	0	9	41										A	87196174	G	A	87196174	3	1	83	1	0	0	0	0	1	0	0	0	40	1290	45	1	3477	1	ABCB1	7	87196174	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3372340	87196174	71942489	206	25050										
SLC26A5	375611	broad.mit.edu	37	chr7	103018061	103018061	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cttacccctgccagagttttCactccaacagaatcaataaa	4	13	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:103018061C>T	uc003vbz.2	-	18	2207	c.1971G>A	c.(1969-1971)GTG>GTA	p.V657V	SLC26A5_uc003vbt.1_Silent_p.V657V|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.V625V|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	657	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						CCAGAGTTTTCACTCCAACAG	0.443													0	0	0	1	0	18	43										T	103018061	C	T	103018061	2	4	83	1	0	0	0	0	0	0	0	1	14520	813	29	1		1	SLC26A5	7	103018061	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	15821887	103018061	56120602	207	25051										
FAM71F1	84691	broad.mit.edu	37	chr7	128356937	128356937	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggccctgggggtgacctcctCggtaccctgcctgcccctcc	12	19	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:128356937C>G	uc003vno.1	+	2	373	c.320C>G	c.(319-321)TCG>TGG	p.S107W	FAM71F1_uc010llo.1_Missense_Mutation_p.S8W|FAM71F1_uc011koq.1_Silent_p.L31L|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Silent_p.L28L|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.S107W	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	107										skin(1)	1						GTGACCTCCTCGGTACCCTGC	0.587													0	0	0	1	0	7	23										G	128356937	C	G	128356937	3	3	83	1	0	0	0	0	1	0	0	0	5612	893	31	1	326	1	FAM71F1	7	128356937	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	25338876	128356937	30781726	208	25052										
TSPAN33	340348	broad.mit.edu	37	chr7	128806685	128806685	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtatttcaactgctcagaaGacaaccccagtcgagagcgc	9	12	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:128806685G>A	uc003vop.1	+	6	755	c.526G>A	c.(526-528)GAC>AAC	p.D176N	TSPAN33_uc003voq.1_Missense_Mutation_p.D8N	NM_178562	NP_848657	Q86UF1	TSN33_HUMAN	tetraspanin 33	176	Extracellular (Potential).					integral to membrane				ovary(1)	1						CTGCTCAGAAGACAACCCCAG	0.522													0	0	0	1	0	39	143										A	128806685	G	A	128806685	3	1	83	1	0	0	0	0	1	0	0	0	16645	942	33	1	548	1	TSPAN33	7	128806685	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	449748	128806685	30331978	209	25053										
MGAM	8972	broad.mit.edu	37	chr7	141724872	141724872	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cggaactaatttgtatggtgCgcagacattcttcttgtgcc	10	9	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:141724872C>T	uc003vwy.2	+	8	959	c.905C>T	c.(904-906)GCG>GTG	p.A302V		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	302	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTGTATGGTGCGCAGACATTC	0.398													0	0	0	1	0	17	26										T	141724872	C	T	141724872	3	4	83	1	0	0	0	0	1	0	0	0	9541	768	27	2	931	2	MGAM	7	141724872	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	12918187	141724872	17413791	210	25054										
MLL3	58508	broad.mit.edu	37	chr7	151860303	151860303	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caaggtaagtcggaactgtaGaagggaatctgggacacaga	14	6	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:151860303G>A	uc003wla.2	-	43	10578	c.10359C>T	c.(10357-10359)TTC>TTT	p.F3453F	MLL3_uc003wkz.2_Silent_p.F2514F|MLL3_uc003wky.2_Silent_p.F962F	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3453	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CGGAACTGTAGAAGGGAATCT	0.478			N		medulloblastoma								0	0	0	1	0	49	149										A	151860303	G	A	151860303	2	1	83	1	0	0	0	0	0	0	0	1	9622	933	33	1		1	MLL3	7	151860303	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10135431	151860303	7278360	211	25055										
C8orf79	57604	broad.mit.edu	37	chr8	12879157	12879157	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tctggaaaacacttggagtgGctgagagcaccaggcactct	12	10	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:12879157G>C	uc010lsq.2	+	5	1461	c.969G>C	c.(967-969)TGG>TGC	p.W323C	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.W236C|C8orf79_uc010lsr.2_Missense_Mutation_p.W197C	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	323							methyltransferase activity				0						ACTTGGAGTGGCTGAGAGCAC	0.423													0	0	0	1	0	4	41										C	12879157	G	C	12879157	3	2	83	1	0	0	0	0	1	0	0	0	2438	1212	42	4	979	4	C8orf79	8	12879157	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		12879157	133484865	212	25056										
MSR1	4481	broad.mit.edu	37	chr8	16026273	16026273	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ataaagacttcttgaaatctCatttcctcttcgctgtcatt	4	10	4	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:16026273C>T	uc003wwz.2	-	4	522	c.324G>A	c.(322-324)ATG>ATA	p.M108I	MSR1_uc010lsu.2_Missense_Mutation_p.M126I|MSR1_uc003wxa.2_Missense_Mutation_p.M108I|MSR1_uc003wxb.2_Missense_Mutation_p.M108I|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	108	Spacer (Probable).|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTTGAAATCTCATTTCCTCTT	0.403													0	0	0	1	0	33	73										T	16026273	C	T	16026273	3	4	83	1	0	0	0	0	1	0	0	0	9886	826	29	1	1107	1	MSR1	8	16026273	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3147116	16026273	130337749	213	25057										
TGS1	96764	broad.mit.edu	37	chr8	56695312	56695312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taatctgcttcgcagggatcGaaaattgtacaatttgggat	10	6	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:56695312G>A	uc003xsj.3	+	2	494	c.107G>A	c.(106-108)CGA>CAA	p.R36Q	TGS1_uc010lyh.2_Intron	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	36					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CGCAGGGATCGAAAATTGTAC	0.313													0	0	0	1	0	21	55										A	56695312	G	A	56695312	3	1	83	1	0	0	0	0	1	0	0	0	15834	1058	37	1	113	1	TGS1	8	56695312	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	40669039	56695312	89668710	214	25058										
FAM110B	90362	broad.mit.edu	37	chr8	59059267	59059267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acctgcaccgtcactccttcGcggagtccctgaaggtctac	9	16	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:59059267G>A	uc003xtj.1	+	5	1358	c.478G>A	c.(478-480)GCG>ACG	p.A160T		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	160						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TCACTCCTTCGCGGAGTCCCT	0.692													0	0	0	1	0	5	10										A	59059267	G	A	59059267	3	1	83	1	0	0	0	0	1	0	0	0	5397	1087	38	2	480	2	FAM110B	8	59059267	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2363955	59059267	87304755	215	25059										
C8orf34	116328	broad.mit.edu	37	chr8	69351819	69351819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcagtctaaacaagggaaccGtggacaacttcaaagaactt	8	9	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:69351819G>A	uc010lyz.2	+	2	204	c.155G>A	c.(154-156)CGT>CAT	p.R52H	C8orf34_uc010lyx.1_Missense_Mutation_p.R52H|C8orf34_uc010lyy.1_Missense_Mutation_p.R52H|C8orf34_uc003xyb.2_Missense_Mutation_p.R27H	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	52					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CAAGGGAACCGTGGACAACTT	0.403													0	0	0	1	0	17	38										A	69351819	G	A	69351819	3	1	83	1	0	0	0	0	1	0	0	0	2422	1145	40	2	82	2	C8orf34	8	69351819	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10292552	69351819	77012203	216	25060										
LY96	23643	broad.mit.edu	37	chr8	74903693	74903693	+	Frame_Shift_Del	DEL	T	T	-													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaatcatgttaccatttctgTttttttccaccctgttttct							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:74903693delT	uc003yad.2	+	1	107	c.16delT	c.(16-18)TTTfs	p.F6fs		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	6					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			ACCATTTCTGTTTTTTTCCAC	0.368																		23	75	---	---								-	74903693	T	-	74903693	7	5	83	1	0	1	0	1	0	0	0	0	9102	1725	60	0	18	0	LY96	8	74903693	Frame_Shift_Del	DEL	T	TCGA-FD-A3SO-01A-11D-A22Z-08	5551874	74903693	71460329	217	25061										
FLJ43860	389690	broad.mit.edu	37	chr8	142490071	142490071	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cttgcaggtgtctcctgaccGtggcaccgtttttttcagct	10	12	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:142490071G>T	uc003ywi.2	-	8	995	c.914C>A	c.(913-915)ACG>AAG	p.T305K	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	305							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCTCCTGACCGTGGCACCGTT	0.597													1	0	1.15088e-07	1	1.1852e-07	10	35										T	142490071	G	T	142490071	3	4	83	1	0	0	0	0	1	0	0	0	5930	1145	40	4	3134	4	FLJ43860	8	142490071	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	67586378	142490071	3873951	218	25062										
CYHR1	50626	broad.mit.edu	37	chr8	145689921	145689921	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcaaggcagtcttcgtgtgtGctcagccctggggccagcgt	15	12	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:145689921G>A	uc003zcv.2	-	2	302	c.168C>T	c.(166-168)AGC>AGT	p.S56S	CYHR1_uc003zcw.2_Silent_p.S56S|CYHR1_uc003zcx.2_Silent_p.S56S|CYHR1_uc003zcy.2_Silent_p.S56S|KIFC2_uc003zcz.2_5'Flank	NM_138496	NP_612505	Q6ZMK1	CYHR1_HUMAN	cysteine/histidine-rich 1 isoform 1	56						perinuclear region of cytoplasm	zinc ion binding				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTTCGTGTGTGCTCAGCCCTG	0.637													0	0	0	1	0	20	65										A	145689921	G	A	145689921	2	1	83	1	0	0	0	0	0	0	0	1	4140	1310	46	2		2	CYHR1	8	145689921	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3199850	145689921	674101	219	25063										
DMRT3	58524	broad.mit.edu	37	chr9	990293	990293	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cctcctgattgagggcccctCggggactgtttctctgccct	11	15	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:990293C>T	uc003zgw.1	+	2	745	c.707C>T	c.(706-708)TCG>TTG	p.S236L		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	236					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GAGGGCCCCTCGGGGACTGTT	0.572													0	0	0	1	0	18	46										T	990293	C	T	990293	3	4	83	1	0	0	0	0	1	0	0	0	4587	893	31	1	713	1	DMRT3	9	990293	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		990293	140223138	220	25064										
KDM4C	23081	broad.mit.edu	37	chr9	7174705	7174705	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttttgaagagctctttccaGaagaagtgccagaagagaca	10	7	1	6			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:7174705G>A	uc003zkh.2	+	22	3727	c.3147G>A	c.(3145-3147)CAG>CAA	p.Q1049Q	KDM4C_uc011lmk.1_Silent_p.Q794Q|KDM4C_uc011lml.1_Silent_p.Q736Q	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	1049					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						GCTCTTTCCAGAAGAAGTGCC	0.498													0	0	0	1	0	43	114										A	7174705	G	A	7174705	2	1	83	1	0	0	0	0	0	0	0	1	8130	933	33	1		1	KDM4C	9	7174705	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6184412	7174705	134038726	221	25065										
PTPRD	5789	broad.mit.edu	37	chr9	8485769	8485769	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agacaaatcctaccttgatcCacaggcagtgtcctgaactg	8	12	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:8485769C>A	uc003zkk.2	-	27	3759	c.3048G>T	c.(3046-3048)GTG>GTT	p.V1016V	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.V1007V|PTPRD_uc003zkm.2_Silent_p.V1003V|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1016	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TACCTTGATCCACAGGCAGTG	0.448										TSP Lung(15;0.13)			1	0	5.9392e-07	1	6.10418e-07	4	9										A	8485769	C	A	8485769	2	1	83	1	0	0	0	0	0	0	0	1	12799	581	21	4		4	PTPRD	9	8485769	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1311064	8485769	132727662	222	25066										
PTPRD	5789	broad.mit.edu	37	chr9	8633395	8633395	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acattcataaatggcctcatCcctcggagtccgtaagggtt	9	11	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:8633395C>G	uc003zkk.2	-	13	985	c.274G>C	c.(274-276)GAT>CAT	p.D92H	PTPRD_uc003zkp.2_Missense_Mutation_p.D92H|PTPRD_uc003zkq.2_Missense_Mutation_p.D92H|PTPRD_uc003zkr.2_Missense_Mutation_p.D92H|PTPRD_uc003zks.2_Missense_Mutation_p.D92H|PTPRD_uc003zkl.2_Missense_Mutation_p.D92H|PTPRD_uc003zkm.2_Missense_Mutation_p.D92H|PTPRD_uc003zkn.2_Missense_Mutation_p.D92H|PTPRD_uc003zko.2_Missense_Mutation_p.D92H|PTPRD_uc003zkt.1_Missense_Mutation_p.D92H	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	92	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATGGCCTCATCCCTCGGAGTC	0.443										TSP Lung(15;0.13)			0	0	0	1	0	28	72										G	8633395	C	G	8633395	3	3	83	1	0	0	0	0	1	0	0	0	12799	855	30	1	5664	1	PTPRD	9	8633395	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	147626	8633395	132580036	223	25067										
PSIP1	11168	broad.mit.edu	37	chr9	15474012	15474012	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgtaaactttataccttttCaccttcttgatcatctcctt	2	11	4	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:15474012C>T	uc003zlv.3	-	9	1183	c.853G>A	c.(853-855)GAA>AAA	p.E285K	PSIP1_uc003zlw.3_Missense_Mutation_p.E285K|PSIP1_uc003zlz.3_Missense_Mutation_p.E285K|PSIP1_uc003zma.3_Missense_Mutation_p.E276K|PSIP1_uc003zly.2_Missense_Mutation_p.E285K	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	285					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TATACCTTTTCACCTTCTTGA	0.249													0	0	0	1	0	8	46										T	15474012	C	T	15474012	3	4	83	1	0	0	0	0	1	0	0	0	12663	835	29	1	800	1	PSIP1	9	15474012	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6840617	15474012	125739419	224	25068										
C9orf72	203228	broad.mit.edu	37	chr9	27561630	27561630	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcaccaatatcatcatcattGagtactgtatcagctatcta	4	10	6	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:27561630G>C	uc003zqq.2	-	5	715	c.618C>G	c.(616-618)CTC>CTG	p.L206L	C9orf72_uc003zqr.1_Silent_p.L206L	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	206										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		CATCATCATTGAGTACTGTAT	0.313													0	0	0	1	0	11	41										C	27561630	G	C	27561630	2	2	83	1	0	0	0	0	0	0	0	1	2495	1277	45	1		1	C9orf72	9	27561630	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	12087618	27561630	113651801	225	25069										
BAG1	573	broad.mit.edu	37	chr9	33256861	33256861	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtggcttttactctcctatCaagtttgcagagagcttcag	9	9	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:33256861C>T	uc003zsj.2	-	5	912	c.823G>A	c.(823-825)GAT>AAT	p.D275N	SUGT1P1_uc010mjq.1_Intron|BAG1_uc003zsi.2_Missense_Mutation_p.D137N|BAG1_uc003zsk.2_Missense_Mutation_p.D101N	NM_004323	NP_004314	Q99933	BAG1_HUMAN	BCL2-associated athanogene isoform 1L	275	Interaction with PPP1R15A.|BAG.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			ACTCTCCTATCAAGTTTGCAG	0.428													0	0	0	1	0	22	66										T	33256861	C	T	33256861	3	4	83	1	0	0	0	0	1	0	0	0	1286	826	29	1	226	1	BAG1	9	33256861	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	5695231	33256861	107956570	226	25070										
SLC28A3	64078	broad.mit.edu	37	chr9	86917179	86917179	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agacagcatctcatcaattcGatgttcgtatttggccatca	7	10	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:86917179G>A	uc010mpz.2	-	5	585	c.460C>T	c.(460-462)CGA>TGA	p.R154*	SLC28A3_uc011lsy.1_Nonsense_Mutation_p.R85*|SLC28A3_uc004anu.1_Nonsense_Mutation_p.R154*|SLC28A3_uc010mqb.2_Nonsense_Mutation_p.R85*	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	154	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TCATCAATTCGATGTTCGTAT	0.453													0	0	0	1	0	21	45										A	86917179	G	A	86917179	4	1	83	1	0	0	0	0	0	1	0	0	14533	1066	37	1	1671	1	SLC28A3	9	86917179	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	53660318	86917179	54296252	227	25071										
ROR2	4920	broad.mit.edu	37	chr9	94493358	94493358	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgggggtgctgcagggcccaCggctggcactggtggcctga	19	11	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:94493358C>T	uc004arj.1	-	7	1216	c.1017G>A	c.(1015-1017)CCG>CCA	p.P339P	ROR2_uc004ari.1_Silent_p.P199P|ROR2_uc004ark.2_Silent_p.P339P	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	339	Extracellular (Potential).|Kringle.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCAGGGCCCACGGCTGGCACT	0.612													0	0	0	1	0	33	51										T	94493358	C	T	94493358	2	4	83	1	0	0	0	0	0	0	0	1	13527	523	19	2		2	ROR2	9	94493358	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7576179	94493358	46720073	228	25072										
FGD3	89846	broad.mit.edu	37	chr9	95784614	95784614	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgtgtcccttctagatcacGagcaccagccctgtggagcc	10	15	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:95784614G>A	uc004asw.2	+	14	2128	c.1500G>A	c.(1498-1500)ACG>ACA	p.T500T	FGD3_uc004asx.2_Silent_p.T500T|FGD3_uc004asz.2_Silent_p.T500T|FGD3_uc011luc.1_Silent_p.T103T	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	500					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						TCTAGATCACGAGCACCAGCC	0.637													0	0	0	1	0	16	40										A	95784614	G	A	95784614	2	1	83	1	0	0	0	0	0	0	0	1	5834	1045	37	1		1	FGD3	9	95784614	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1291256	95784614	45428817	229	25073										
ZNF462	58499	broad.mit.edu	37	chr9	109690005	109690005	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actcaaatgtaggcagtgctCatatacctccccctacttct	5	14	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:109690005C>T	uc004bcz.2	+	3	4101	c.3812C>T	c.(3811-3813)TCA>TTA	p.S1271L	ZNF462_uc010mto.2_Missense_Mutation_p.S1119L|ZNF462_uc004bda.2_Missense_Mutation_p.S1119L	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1271	C2H2-type 11.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AGGCAGTGCTCATATACCTCC	0.522													0	0	0	1	0	70	158										T	109690005	C	T	109690005	3	4	83	1	0	0	0	0	1	0	0	0	17923	838	29	1	3818	1	ZNF462	9	109690005	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	13905391	109690005	31523426	230	25074										
ZNF462	58499	broad.mit.edu	37	chr9	109690177	109690177	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acggagcccaacggtttgctCctgcattaccaacggaggca	11	13	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:109690177C>G	uc004bcz.2	+	3	4273	c.3984C>G	c.(3982-3984)CTC>CTG	p.L1328L	ZNF462_uc010mto.2_Silent_p.L1176L|ZNF462_uc004bda.2_Silent_p.L1176L	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1328					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ACGGTTTGCTCCTGCATTACC	0.527													0	0	0	1	0	33	105										G	109690177	C	G	109690177	2	3	83	1	0	0	0	0	0	0	0	1	17923	842	30	1		1	ZNF462	9	109690177	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	172	109690177	31523254	231	25075										
RAD23B	5887	broad.mit.edu	37	chr9	110062443	110062451	+	In_Frame_Del	DEL	ATTGAATCT	ATTGAATCT	-													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgaaagcactgaaagagaagAttgaatctgaaaaggggaaa							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:110062443_110062451delATTGAATCT	uc004bde.2	+	2	455_463	c.88_96delATTGAATCT	c.(88-96)ATTGAATCTdel	p.IES30del	RAD23B_uc011lwa.1_In_Frame_Del_p.IES30del|RAD23B_uc011lwb.1_In_Frame_Del_p.IES9del	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	30_32	Ubiquitin-like.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						GAAAGAGAAGATTGAATCTGAAAAGGGGA	0.287								Direct_reversal_of_damage|NER										16	55	---	---								-	110062451	ATTGAATCT	-	110062443	7	5	83	1	0	1	0	1	0	0	0	0	12983	333	12	0	94	0	RAD23B	9	110062443	In_Frame_Del	DEL	ATTGAATCT	TCGA-FD-A3SO-01A-11D-A22Z-08	372266	110062443	31150988	232	25076										
KLF4	9314	broad.mit.edu	37	chr9	110250458	110250458	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggctccgccgctctccaggtCtgtggccacggtcgccgccg	14	18	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:110250458C>T	uc004bdh.2	-	3	811	c.190G>A	c.(190-192)GAC>AAC	p.D64N	KLF4_uc004bdf.1_Missense_Mutation_p.D23N|KLF4_uc004bdg.2_Missense_Mutation_p.D73N	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	73					fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						CTCTCCAGGTCTGTGGCCACG	0.697													0	0	0	1	0	5	20										T	110250458	C	T	110250458	3	4	83	1	0	0	0	0	1	0	0	0	8348	913	32	1	1234	1	KLF4	9	110250458	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	188015	110250458	30962973	233	25077										
KIAA0368	23392	broad.mit.edu	37	chr9	114134882	114134882	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	catgaatagtcaaagcacaaGaggtcttgtagataggttct	10	6	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:114134882G>C	uc004bfe.1	-	43	4889	c.4889C>G	c.(4888-4890)TCT>TGT	p.S1630C		NM_001080398	NP_001073867			KIAA0368 protein												0						CAAAGCACAAGAGGTCTTGTA	0.363													0	0	0	1	0	5	24										C	114134882	G	C	114134882	3	2	83	1	0	0	0	0	1	0	0	0	8171	942	33	1	1200	1	KIAA0368	9	114134882	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3884424	114134882	27078549	234	25078										
DBC1	1620	broad.mit.edu	37	chr9	121929416	121929416	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttgaggatctccgtgttgtaCaggtccaaggcgtggttcac	13	9	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:121929416C>T	uc004bkc.2	-	8	2688	c.2232G>A	c.(2230-2232)CTG>CTA	p.L744L		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	744					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CCGTGTTGTACAGGTCCAAGG	0.527													0	0	0	1	0	28	127										T	121929416	C	T	121929416	2	4	83	1	0	0	0	0	0	0	0	1	4247	465	17	2		2	DBC1	9	121929416	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7794534	121929416	19284015	235	25079										
DBC1	1620	broad.mit.edu	37	chr9	121930184	121930184	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atcttctgcagcaggtacttCagctccaggtcctggaagtc	10	12	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:121930184C>T	uc004bkc.2	-	8	1920	c.1464G>A	c.(1462-1464)CTG>CTA	p.L488L		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	488					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GCAGGTACTTCAGCTCCAGGT	0.577													0	0	0	1	0	9	34										T	121930184	C	T	121930184	2	4	83	1	0	0	0	0	0	0	0	1	4247	813	29	1		1	DBC1	9	121930184	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	768	121930184	19283247	236	25080										
SH2D3C	10044	broad.mit.edu	37	chr9	130506924	130506924	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccttgaccttgcgcagaagGcccacctccagtggccggtt	11	15	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:130506924G>A	uc004bsc.2	-	7	1861	c.1719C>T	c.(1717-1719)GGC>GGT	p.G573G	SH2D3C_uc010mxo.2_Silent_p.G413G|SH2D3C_uc004bry.2_Silent_p.G415G|SH2D3C_uc004brz.3_Silent_p.G219G|SH2D3C_uc011mak.1_Silent_p.G219G|SH2D3C_uc004bsa.2_Silent_p.G416G|SH2D3C_uc004bsb.2_Silent_p.G505G	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	573					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						TGCGCAGAAGGCCCACCTCCA	0.612													0	0	0	1	0	31	93										A	130506924	G	A	130506924	2	1	83	1	0	0	0	0	0	0	0	1	14234	1190	42	2		2	SH2D3C	9	130506924	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8576740	130506924	10706507	237	25081										
SETX	23064	broad.mit.edu	37	chr9	135153600	135153600	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttctcttccagcagtctgcaGaagcgagccatcattgactg	9	12	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:135153600G>A	uc004cbk.2	-	21	6882	c.6699C>T	c.(6697-6699)TTC>TTT	p.F2233F	SETX_uc004cbj.2_Silent_p.F1852F|SETX_uc010mzt.2_Silent_p.F1852F	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2233					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTCTGCAGAAGCGAGCCA	0.458													0	0	0	1	0	30	88										A	135153600	G	A	135153600	2	1	83	1	0	0	0	0	0	0	0	1	14141	933	33	1		1	SETX	9	135153600	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4646676	135153600	6059831	238	25082										
FCN1	2219	broad.mit.edu	37	chr9	137809709	137809709	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgggccatggtggctccactCagctccatgctctctggcct	11	16	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:137809709C>G	uc004cfi.2	-	1	101	c.9G>C	c.(7-9)CTG>CTC	p.L3L		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	3					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TGGCTCCACTCAGCTCCATGC	0.587													0	0	0	1	0	21	51										G	137809709	C	G	137809709	2	3	83	1	0	0	0	0	0	0	0	1	5791	813	29	1		1	FCN1	9	137809709	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2656109	137809709	3403722	239	25083										
SEC16A	9919	broad.mit.edu	37	chr9	139358973	139358973	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gccaaacctggcacagacatGaggcactgaaaatttttcag	9	10	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:139358973G>A	uc004chx.2	-	9	4654	c.4345C>T	c.(4345-4347)CAT>TAT	p.H1449Y	SEC16A_uc004chv.3_Missense_Mutation_p.H839Y|SEC16A_uc004chw.2_Missense_Mutation_p.H1449Y|SEC16A_uc010nbn.2_Missense_Mutation_p.H1449Y	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1271					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GCACAGACATGAGGCACTGAA	0.458													0	0	0	1	0	20	66										A	139358973	G	A	139358973	3	1	83	1	0	0	0	0	1	0	0	0	13986	1290	45	1	2824	1	SEC16A	9	139358973	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1549264	139358973	1854458	240	25084										
C9orf86	55684	broad.mit.edu	37	chr9	139726762	139726762	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tatgctgagtcttccatgaaGaacagcttcggcctaaagta	9	9	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:139726762G>A	uc004cji.1	+	7	913	c.645G>A	c.(643-645)AAG>AAA	p.K215K	C9orf86_uc004cjm.2_Silent_p.K215K|C9orf86_uc004cjh.2_Silent_p.K215K|C9orf86_uc004cjj.1_Silent_p.K216K|C9orf86_uc004cjk.1_RNA|C9orf86_uc010nbr.1_Silent_p.K215K|C9orf86_uc004cjl.1_RNA|C9orf86_uc010nbs.1_Silent_p.K100K|C9orf86_uc004cjn.1_5'Flank	NM_024718	NP_078994	Q3YEC7	PARF_HUMAN	Rab-like GTP-binding protein 1 isoform 1	215	Small GTPase-like.				small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		CTTCCATGAAGAACAGCTTCG	0.493													0	0	0	1	0	25	58										A	139726762	G	A	139726762	2	1	83	1	0	0	0	0	0	0	0	1	2502	933	33	1		1	C9orf86	9	139726762	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	367789	139726762	1486669	241	25085										
SFMBT2	57713	broad.mit.edu	37	chr10	7262479	7262479	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcaagtttcatgttctttgtGaaacctcgactgaatgatgt	8	7	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:7262479G>A	uc009xio.1	-	11	1315	c.1224C>T	c.(1222-1224)TTC>TTT	p.F408F	SFMBT2_uc001ijn.1_Silent_p.F408F|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	408	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TGTTCTTTGTGAAACCTCGAC	0.502													0	0	0	1	0	18	70										A	7262479	G	A	7262479	2	1	83	1	0	0	0	0	0	0	0	1	14158	1281	45	1		1	SFMBT2	10	7262479	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		7262479	128272268	242	25086										
ARHGAP12	94134	broad.mit.edu	37	chr10	32097634	32097634	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggtttggctttggcaactgtCtgattaggtccttaacagca	11	8	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:32097634C>A	uc001ivz.1	-	19	2579	c.2309G>T	c.(2308-2310)AGA>ATA	p.R770I	ARHGAP12_uc001ivy.1_Missense_Mutation_p.R716I|ARHGAP12_uc009xls.2_Missense_Mutation_p.R721I|ARHGAP12_uc001iwb.1_Missense_Mutation_p.R763I|ARHGAP12_uc001iwc.1_Missense_Mutation_p.R738I|ARHGAP12_uc009xlq.1_Missense_Mutation_p.R691I|ARHGAP12_uc001ivw.1_5'Flank|ARHGAP12_uc001ivx.1_Missense_Mutation_p.R69I	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	770	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TGGCAACTGTCTGATTAGGTC	0.388													1	0	2.74695e-27	1	2.91582e-27	47	136										A	32097634	C	A	32097634	3	1	83	1	0	0	0	0	1	0	0	0	865	913	32	3	239	3	ARHGAP12	10	32097634	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	24835155	32097634	103437113	243	25087										
MAPK8	5599	broad.mit.edu	37	chr10	49633961	49633961	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtggaataaagttattgaacAgcttggaacaccatgtcctg	10	7	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:49633961A>G	uc009xnz.2	+	8	943	c.719A>G	c.(718-720)CAG>CGG	p.Q240R	MAPK8_uc001jgl.2_Missense_Mutation_p.Q240R|MAPK8_uc001jgm.2_Missense_Mutation_p.Q240R|MAPK8_uc001jgo.2_Missense_Mutation_p.Q240R|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.Q240R|MAPK8_uc010qgk.1_Missense_Mutation_p.Q240R|MAPK8_uc001jgp.2_Missense_Mutation_p.Q240R|MAPK8_uc001jgq.2_Missense_Mutation_p.Q240R	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	240	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		GTTATTGAACAGCTTGGAACA	0.318													0	0	0	1	0	9	44										G	49633961	A	G	49633961	3	3	83	1	0	0	0	0	1	0	0	0	9283	188	7	5	821	5	MAPK8	10	49633961	Missense_Mutation	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	17536327	49633961	85900786	244	25088										
A1CF	29974	broad.mit.edu	37	chr10	52619618	52619618	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctacctggaccaagctatatCctgtgcgctggaccagtgcg	11	13	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:52619618C>G	uc001jjj.2	-	3	271	c.83G>C	c.(82-84)GGA>GCA	p.G28A	A1CF_uc010qhn.1_5'UTR|A1CF_uc001jji.2_Missense_Mutation_p.G28A|A1CF_uc001jjh.2_5'UTR|A1CF_uc010qho.1_5'UTR|A1CF_uc009xov.2_Missense_Mutation_p.G28A|A1CF_uc001jjk.1_Missense_Mutation_p.G28A	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	28					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CAAGCTATATCCTGTGCGCTG	0.498													0	0	0	1	0	15	43										G	52619618	C	G	52619618	3	3	83	1	0	0	0	0	1	0	0	0	2	855	30	1	1872	1	A1CF	10	52619618	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2985657	52619618	82915129	245	25089										
CDH23	64072	broad.mit.edu	37	chr10	73326687	73326687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcctaccagctcacggtcaaCgccacagtgagtctccatgc	9	16	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:73326687C>T	uc001jrx.3	+	7	995	c.618C>T	c.(616-618)AAC>AAT	p.N206N	CDH23_uc001jrw.3_Silent_p.N206N|CDH23_uc001jrv.2_Silent_p.N201N|CDH23_uc009xql.2_Silent_p.N251N	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	206	Cadherin 2.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TCACGGTCAACGCCACAGTGA	0.627													0	0	0	1	0	4	24										T	73326687	C	T	73326687	2	4	83	1	0	0	0	0	0	0	0	1	3108	535	19	2		2	CDH23	10	73326687	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	20707069	73326687	62208060	246	25090										
KIF20B	9585	broad.mit.edu	37	chr10	91487639	91487639	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	attcattgattcaagagcttGagacatctaataaggtaatg	8	5	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:91487639G>C	uc001kgs.1	+	17	2329	c.2257G>C	c.(2257-2259)GAG>CAG	p.E753Q	KIF20B_uc001kgr.1_Missense_Mutation_p.E713Q|KIF20B_uc001kgt.1_5'UTR	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	753	Potential.			E -> K (in Ref. 1; BAB69456).	cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TCAAGAGCTTGAGACATCTAA	0.244													0	0	0	1	0	4	21										C	91487639	G	C	91487639	3	2	83	1	0	0	0	0	1	0	0	0	8287	1291	45	1	2199	1	KIF20B	10	91487639	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	18160952	91487639	44047108	247	25091										
CRTAC1	55118	broad.mit.edu	37	chr10	99770957	99770957	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtaactgccacaccatagttGagctgggtgggattactgtc	12	9	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:99770957G>C	uc001kou.1	-	2	518	c.162C>G	c.(160-162)CTC>CTG	p.L54L	CRTAC1_uc001kov.2_Silent_p.L43L	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	54	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CACCATAGTTGAGCTGGGTGG	0.537													0	0	0	1	0	35	83										C	99770957	G	C	99770957	2	2	83	1	0	0	0	0	0	0	0	1	3896	1277	45	1		1	CRTAC1	10	99770957	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8283318	99770957	35763790	248	25092										
C10orf28	27291	broad.mit.edu	37	chr10	99969078	99969078	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tagttgcagttagaatagctGatgagacctctattaataca	8	6	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:99969078G>C	uc001kow.3	+	4	1502	c.1207G>C	c.(1207-1209)GAT>CAT	p.D403H	C10orf28_uc001kox.3_Missense_Mutation_p.D403H|C10orf28_uc001koy.3_Missense_Mutation_p.D403H|C10orf28_uc009xvx.2_Missense_Mutation_p.D403H|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	403							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		TAGAATAGCTGATGAGACCTC	0.398													0	0	0	1	0	41	100										C	99969078	G	C	99969078	3	2	83	1	0	0	0	0	1	0	0	0	1601	1290	45	1	1209	1	C10orf28	10	99969078	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	198121	99969078	35565669	249	25093										
CHUK	1147	broad.mit.edu	37	chr10	101981902	101981902	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taaagaaagtatctggctttCtttaagtccacaacaatttt	5	7	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:101981902C>G	uc001kqp.2	-	4	407	c.352G>C	c.(352-354)GAA>CAA	p.E118Q		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	118	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ATCTGGCTTTCTTTAAGTCCA	0.348													0	0	0	1	0	4	24										G	101981902	C	G	101981902	3	3	83	1	0	0	0	0	1	0	0	0	3416	922	32	1	1957	1	CHUK	10	101981902	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2012824	101981902	33552845	250	25094										
KCNIP2	30819	broad.mit.edu	37	chr10	103587157	103587157	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggacctcatgatgttctcatCctgtggccatgatgtgagcg	12	10	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103587157C>A	uc001kub.2	-	10	1118	c.766G>T	c.(766-768)GAT>TAT	p.D256Y	KCNIP2_uc010qqg.1_Missense_Mutation_p.D200Y|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.D154Y|KCNIP2_uc001ktz.2_Missense_Mutation_p.D211Y|KCNIP2_uc009xwu.2_Missense_Mutation_p.D205Y|KCNIP2_uc009xwv.2_Missense_Mutation_p.D202Y|KCNIP2_uc001kuc.2_Missense_Mutation_p.D271Y|KCNIP2_uc001kue.2_Missense_Mutation_p.D238Y|KCNIP2_uc001kud.2_Missense_Mutation_p.D213Y|KCNIP2_uc001kuf.2_Missense_Mutation_p.D206Y|KCNIP2_uc001kua.2_Missense_Mutation_p.D187Y|KCNIP2_uc009xww.2_RNA	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	256	EF-hand 4.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		ATGTTCTCATCCTGTGGCCAT	0.522													1	0	1.55469e-16	1	1.62693e-16	25	111										A	103587157	C	A	103587157	3	1	83	1	0	0	0	0	1	0	0	0	8040	869	30	3	50	3	KCNIP2	10	103587157	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1605255	103587157	31947590	251	25095										
KCNIP2	30819	broad.mit.edu	37	chr10	103587660	103587660	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagtacctggaagaagctctCcacgtgttcccttggggcct	11	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103587660C>G	uc001kub.2	-	8	1040	c.688G>C	c.(688-690)GAG>CAG	p.E230Q	KCNIP2_uc010qqg.1_Missense_Mutation_p.E174Q|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.E128Q|KCNIP2_uc001ktz.2_Missense_Mutation_p.E185Q|KCNIP2_uc009xwu.2_Missense_Mutation_p.E180Q|KCNIP2_uc009xwv.2_Missense_Mutation_p.E176Q|KCNIP2_uc001kuc.2_Missense_Mutation_p.E245Q|KCNIP2_uc001kue.2_Missense_Mutation_p.E212Q|KCNIP2_uc001kud.2_Missense_Mutation_p.E187Q|KCNIP2_uc001kuf.2_Missense_Mutation_p.E180Q|KCNIP2_uc001kua.2_Missense_Mutation_p.E161Q|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Missense_Mutation_p.E185Q|KCNIP2_uc010qqi.1_Missense_Mutation_p.E144Q	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	230	EF-hand 4.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		AAGAAGCTCTCCACGTGTTCC	0.557													0	0	0	1	0	15	58										G	103587660	C	G	103587660	3	3	83	1	0	0	0	0	1	0	0	0	8040	864	30	1	183	1	KCNIP2	10	103587660	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	503	103587660	31947087	252	25096										
KCNIP2	30819	broad.mit.edu	37	chr10	103588900	103588900	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggtttgctcctgcagctgctCcagaccctcaggccggtgac	12	15	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103588900C>G	uc001kub.2	-	4	632	c.280G>C	c.(280-282)GAG>CAG	p.E94Q	KCNIP2_uc010qqg.1_5'Flank|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.W15C|KCNIP2_uc001ktz.2_Missense_Mutation_p.E49Q|KCNIP2_uc009xwu.2_Missense_Mutation_p.E44Q|KCNIP2_uc009xwv.2_Missense_Mutation_p.E44Q|KCNIP2_uc001kuc.2_Missense_Mutation_p.E109Q|KCNIP2_uc001kue.2_Missense_Mutation_p.E76Q|KCNIP2_uc001kud.2_Missense_Mutation_p.E44Q|KCNIP2_uc001kuf.2_Missense_Mutation_p.E44Q|KCNIP2_uc001kua.2_Missense_Mutation_p.W15C|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Missense_Mutation_p.E49Q|KCNIP2_uc010qqi.1_Missense_Mutation_p.E44Q	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	94	EF-hand 1; degenerate.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		TGCAGCTGCTCCAGACCCTCA	0.617													0	0	0	1	0	10	28										G	103588900	C	G	103588900	3	3	83	1	0	0	0	0	1	0	0	0	8040	864	30	1	628	1	KCNIP2	10	103588900	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1240	103588900	31945847	253	25097										
PPRC1	23082	broad.mit.edu	37	chr10	103900787	103900787	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtaagcaaacctgtggcctCatctcccactgagcaggtgc	10	13	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103900787C>T	uc001kum.2	+	5	2561	c.2522C>T	c.(2521-2523)TCA>TTA	p.S841L	PPRC1_uc001kun.2_Missense_Mutation_p.S721L|PPRC1_uc010qqj.1_Missense_Mutation_p.S841L|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	841	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCTGTGGCCTCATCTCCCACT	0.597													0	0	0	1	0	33	49										T	103900787	C	T	103900787	3	4	83	1	0	0	0	0	1	0	0	0	12410	838	29	1	2540	1	PPRC1	10	103900787	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	311887	103900787	31633960	254	25098										
SLK	9748	broad.mit.edu	37	chr10	105780291	105780291	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agaaaaatgagagaatggctCagcatcagaaacatgagaat	10	5	2	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:105780291C>T	uc001kxo.1	+	17	3401	c.3367C>T	c.(3367-3369)CAG>TAG	p.Q1123*	SLK_uc001kxp.1_Nonsense_Mutation_p.Q1092*	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1123	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAGAATGGCTCAGCATCAGAA	0.393													0	0	0	1	0	12	46										T	105780291	C	T	105780291	4	4	83	1	0	0	0	0	0	1	0	0	14748	827	29	1	3433	1	SLK	10	105780291	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1879504	105780291	29754456	255	25099										
SLK	9748	broad.mit.edu	37	chr10	105780327	105780327	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agaatcaaatgcgagatcttCagttgcagtgtgaagccaat	10	7	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:105780327C>A	uc001kxo.1	+	17	3437	c.3403C>A	c.(3403-3405)CAG>AAG	p.Q1135K	SLK_uc001kxp.1_Missense_Mutation_p.Q1104K	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1135	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GCGAGATCTTCAGTTGCAGTG	0.453													1	0	3.41278e-10	1	3.55698e-10	15	56										A	105780327	C	A	105780327	3	1	83	1	0	0	0	0	1	0	0	0	14748	827	29	3	3469	3	SLK	10	105780327	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	36	105780327	29754420	256	25100										
GFRA1	2674	broad.mit.edu	37	chr10	117884737	117884737	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccagtgcccacttacctgcaGatgtaattcgtcttgcagga	9	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:117884737G>C	uc001lcj.2	-	6	1463	c.765C>G	c.(763-765)ATC>ATG	p.I255M	GFRA1_uc001lci.2_Missense_Mutation_p.I250M|GFRA1_uc009xyr.2_Missense_Mutation_p.I250M	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	255	3.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTTACCTGCAGATGTAATTCG	0.537													0	0	0	1	0	16	26										C	117884737	G	C	117884737	3	2	83	1	0	0	0	0	1	0	0	0	6347	932	33	1	656	1	GFRA1	10	117884737	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	12104410	117884737	17650010	257	25101										
PDZD8	118987	broad.mit.edu	37	chr10	119134253	119134253	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gagggcacgactggccgcacGagccggatggtcttgatgaa	16	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:119134253G>A	uc001lde.1	-	1	685	c.486C>T	c.(484-486)CTC>CTT	p.L162L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	162					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CTGGCCGCACGAGCCGGATGG	0.731													0	0	0	1	0	4	17										A	119134253	G	A	119134253	2	1	83	1	0	0	0	0	0	0	0	1	11705	1045	37	1		1	PDZD8	10	119134253	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1249516	119134253	16400494	258	25102										
BCCIP	56647	broad.mit.edu	37	chr10	127512238	127512238	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagtcgaaaatgaggatgaaGacgatgatgacagtgacaag	13	4	0	6			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512238G>A	uc001ljb.3	+	1	135	c.112G>A	c.(112-114)GAC>AAC	p.D38N	BCCIP_uc001ljd.3_Missense_Mutation_p.D38N|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.D38N|BCCIP_uc001ljc.3_Missense_Mutation_p.D38N|BCCIP_uc010quj.1_Missense_Mutation_p.D38N	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	38					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				tgaggatgaagacgatgatga	0.343													0	0	0	1	0	5	59										A	127512238	G	A	127512238	3	1	83	1	0	0	0	0	1	0	0	0	1356	942	33	1	114	1	BCCIP	10	127512238	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8377985	127512238	8022509	259	25103										
BCCIP	56647	broad.mit.edu	37	chr10	127512271	127512271	+	Missense_Mutation	SNP	G	G	A													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtgacaaggaaaaggatgaaGaggacgaggtcattgacgag							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512271G>A	uc001ljb.3	+	1	168	c.145G>A	c.(145-147)GAG>AAG	p.E49K	BCCIP_uc001ljd.3_Missense_Mutation_p.E49K|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.E49K|BCCIP_uc001ljc.3_Missense_Mutation_p.E49K|BCCIP_uc010quj.1_Missense_Mutation_p.E49K	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	49					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				aaaggatgaagaggacgaggT	0.308													0	0	0	1	0	10	53										A	127512271	G	A	127512271	3	1	83	1	0	0	0	0	1	0	0	0	1356	943	33	1	147	1	BCCIP	10	127512271	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	33	127512271	8022476	260	25104	125	2								
BCCIP	56647	broad.mit.edu	37	chr10	127512277	127512277	+	Missense_Mutation	SNP	G	G	A													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggaaaaggatgaagaggacGaggtcattgacgaggtgaga							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512277G>A	uc001ljb.3	+	1	174	c.151G>A	c.(151-153)GAG>AAG	p.E51K	BCCIP_uc001ljd.3_Missense_Mutation_p.E51K|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.E51K|BCCIP_uc001ljc.3_Missense_Mutation_p.E51K|BCCIP_uc010quj.1_Missense_Mutation_p.E51K	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	51					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				tgaagaggacgaggTCATTGA	0.303													0	0	0	1	0	9	52										A	127512277	G	A	127512277	3	1	83	1	0	0	0	0	1	0	0	0	1356	1059	37	1	153	1	BCCIP	10	127512277	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6	127512277	8022470	261	25105	125	2								
DUSP8	1850	broad.mit.edu	37	chr11	1586886	1586886	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accttgccctgctgcagccgCcgcttcaccagcttggagca	10	17	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:1586886C>G	uc001lts.2	-	2	299	c.171G>C	c.(169-171)CGG>CGC	p.R57R		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	57	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GCTGCAGCCGCCGCTTCACCA	0.647													0	0	0	1	0	18	42										G	1586886	C	G	1586886	2	3	83	1	0	0	0	0	0	0	0	1	4831	726	26	4		4	DUSP8	11	1586886	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		1586886	133419630	262	25106										
UBQLNL	143630	broad.mit.edu	37	chr11	5537271	5537271	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taccagttggttggtgcactCtgctgctgtttcctttggtg	12	9	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:5537271C>G	uc001maz.3	-	1	686	c.401G>C	c.(400-402)AGA>ACA	p.R134T	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	134										large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TTGGTGCACTCTGCTGCTGTT	0.537													0	0	0	1	0	17	55										G	5537271	C	G	5537271	3	3	83	1	0	0	0	0	1	0	0	0	16897	913	32	1	1030	1	UBQLNL	11	5537271	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3950385	5537271	129469245	263	25107										
OR52E4	390081	broad.mit.edu	37	chr11	5905783	5905783	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cccaaaatgctaggaatcttCtggttcaacctccaagagat	7	11	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:5905783C>G	uc010qzs.1	+	1	261	c.261C>G	c.(259-261)TTC>TTG	p.F87L	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGAATCTTCTGGTTCAACC	0.458													0	0	0	1	0	40	106										G	5905783	C	G	5905783	3	3	83	1	0	0	0	0	1	0	0	0	11116	912	32	1	263	1	OR52E4	11	5905783	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	368512	5905783	129100733	264	25108										
PIK3C2A	5286	broad.mit.edu	37	chr11	17112890	17112890	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttttaacttaccatttcattGaatgtcggattcctcgtttt	5	8	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:17112890G>A	uc001mmq.3	-	31	4935	c.4869C>T	c.(4867-4869)TTC>TTT	p.F1623F	PIK3C2A_uc009ygu.1_Silent_p.F226F|PIK3C2A_uc010rcw.1_Silent_p.F1243F|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1623	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	CCATTTCATTGAATGTCGGAT	0.249													0	0	0	1	0	18	57										A	17112890	G	A	17112890	2	1	83	1	0	0	0	0	0	0	0	1	11909	1281	45	1		1	PIK3C2A	11	17112890	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	11207107	17112890	117893626	265	25109										
NELL1	4745	broad.mit.edu	37	chr11	21581919	21581919	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaagacaggtgttctgtctgCtcctgcaaggtgaggctgat	14	8	2	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:21581919C>T	uc001mqe.2	+	17	2124	c.1971C>T	c.(1969-1971)TGC>TGT	p.C657C	NELL1_uc001mqf.2_Silent_p.C610C|NELL1_uc009yid.2_Silent_p.C685C|NELL1_uc010rdo.1_Silent_p.C600C|NELL1_uc010rdp.1_Silent_p.C370C|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	657	VWFC 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GTTCTGTCTGCTCCTGCAAGG	0.542													0	0	0	1	0	14	20										T	21581919	C	T	21581919	2	4	83	1	0	0	0	0	0	0	0	1	10333	805	28	2		2	NELL1	11	21581919	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4469029	21581919	113424597	266	25110										
KIF18A	81930	broad.mit.edu	37	chr11	28104452	28104452	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aatcattaactttgcttggtCattttcattagtgaaggctt	7	6	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:28104452C>T	uc001msc.2	-	9	1395	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	405	Potential.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TTTGCTTGGTCATTTTCATTA	0.264													0	0	0	1	0	4	34										T	28104452	C	T	28104452	3	4	83	1	0	0	0	0	1	0	0	0	8280	826	29	1	1519	1	KIF18A	11	28104452	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6522533	28104452	106902064	267	25111										
TTC17	55761	broad.mit.edu	37	chr11	43380573	43380573	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccggcccaggctggctcctCagcctttccgccttgctgag	11	17	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:43380573C>T	uc001mxi.2	+	1	83	c.69C>T	c.(67-69)CTC>CTT	p.L23L	TTC17_uc001mxh.2_Silent_p.L23L	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	23							binding			ovary(5)	5						GCTGGCTCCTCAGCCTTTCCG	0.711													0	0	0	1	0	4	7										T	43380573	C	T	43380573	2	4	83	1	0	0	0	0	0	0	0	1	16681	813	29	1		1	TTC17	11	43380573	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	15276121	43380573	91625943	268	25112										
OR4B1	119765	broad.mit.edu	37	chr11	48238743	48238743	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acgtggccatttgcaagcctCttcattatatgaacattatc	6	10	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:48238743C>G	uc010rhs.1	+	1	382	c.382C>G	c.(382-384)CTT>GTT	p.L128V		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TTGCAAGCCTCTTCATTATAT	0.453													0	0	0	1	0	41	87										G	48238743	C	G	48238743	3	3	83	1	0	0	0	0	1	0	0	0	11044	913	32	1	384	1	OR4B1	11	48238743	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4858170	48238743	86767773	269	25113										
OR4C6	219432	broad.mit.edu	37	chr11	55433227	55433227	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacacccacatcctgggcctCttagttaccctcaacagtgg	8	15	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:55433227C>T	uc001nht.3	+	3	850	c.585C>T	c.(583-585)CTC>CTT	p.L195L	OR4C6_uc010rik.1_Silent_p.L195L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	195	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCCTGGGCCTCTTAGTTACCC	0.443													0	0	0	1	0	35	78										T	55433227	C	T	55433227	2	4	83	1	0	0	0	0	0	0	0	1	11052	900	32	1		1	OR4C6	11	55433227	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7194484	55433227	79573289	270	25114										
MS4A7	58475	broad.mit.edu	37	chr11	60154219	60154219	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actggatccctctcaattatCtctggaaaacaatcaactaa	4	11	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:60154219C>T	uc001npe.2	+	4	457	c.312C>T	c.(310-312)ATC>ATT	p.I104I	MS4A7_uc001npf.2_Silent_p.I104I|MS4A7_uc001npg.2_Silent_p.I59I|MS4A7_uc001nph.2_Silent_p.I59I|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Silent_p.I59I	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	104	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						TCTCAATTATCTCTGGAAAAC	0.284													0	0	0	1	0	24	55										T	60154219	C	T	60154219	2	4	83	1	0	0	0	0	0	0	0	1	9866	903	32	1		1	MS4A7	11	60154219	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4720992	60154219	74852297	271	25115										
EML3	256364	broad.mit.edu	37	chr11	62378910	62378910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgcatacctgtcccccggagGagctggtgtgccagagccct	13	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:62378910G>A	uc001ntu.1	-	2	489	c.181C>T	c.(181-183)CCT>TCT	p.P61S	EML3_uc001ntr.1_Missense_Mutation_p.P32S|EML3_uc001nts.1_Missense_Mutation_p.P32S|EML3_uc001ntt.1_5'UTR|EML3_uc010rly.1_Missense_Mutation_p.P61S|EML3_uc009yny.1_5'Flank|ROM1_uc001ntv.2_5'Flank	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	61						cytoplasm|microtubule	protein binding			ovary(1)	1						TCCCCCGGAGGAGCTGGTGTG	0.602													0	0	0	1	0	8	30										A	62378910	G	A	62378910	3	1	83	1	0	0	0	0	1	0	0	0	5098	1174	41	1	2593	1	EML3	11	62378910	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2224691	62378910	72627606	272	25116										
ATG2A	23130	broad.mit.edu	37	chr11	64670063	64670063	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cctgtgctcattacgtactgGagcaggttgaccagcagggc	13	11	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:64670063G>C	uc001obx.2	-	27	3817	c.3702C>G	c.(3700-3702)CTC>CTG	p.L1234L	ATG2A_uc001obw.2_5'UTR	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1234							protein binding			ovary(1)|central_nervous_system(1)	2						TTACGTACTGGAGCAGGTTGA	0.652													0	0	0	1	0	4	10										C	64670063	G	C	64670063	2	2	83	1	0	0	0	0	0	0	0	1	1093	1161	41	1		1	ATG2A	11	64670063	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2291153	64670063	70336453	273	25117										
ADRBK1	156	broad.mit.edu	37	chr11	67052909	67052909	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctggtccagcgcggcagtgcCaacggcctctgacccgccca	12	18	1	1	rs144172325		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:67052909C>T	uc009yrn.1	+	21	2324	c.2058C>T	c.(2056-2058)GCC>GCT	p.A686A	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	686					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCGGCAGTGCCAACGGCCTCT	0.542													0	0	0	1	0	7	16										T	67052909	C	T	67052909	2	4	83	1	0	0	0	0	0	0	0	1	343	581	21	2		2	ADRBK1	11	67052909	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2382846	67052909	67953607	274	25118										
C11orf24	53838	broad.mit.edu	37	chr11	68029775	68029775	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtgcttggaaggacttggacGagtgctcatggggctgcttg	17	7	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:68029775G>A	uc001onr.3	-	4	1130	c.688C>T	c.(688-690)CGT>TGT	p.R230C	C11orf24_uc001ons.2_Missense_Mutation_p.R230C	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	230	Extracellular (Potential).|Pro-rich.					integral to membrane					0						GGACTTGGACGAGTGCTCATG	0.587													0	0	0	1	0	20	60										A	68029775	G	A	68029775	3	1	83	1	0	0	0	0	1	0	0	0	1635	1058	37	1	665	1	C11orf24	11	68029775	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	976866	68029775	66976741	275	25119										
MRGPRF	116535	broad.mit.edu	37	chr11	68773667	68773667	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggaggcggcagcatcgcgatCtgctcgatggtcaggaagcc	16	11	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:68773667C>T	uc001ooo.3	-	3	478	c.111G>A	c.(109-111)CAG>CAA	p.Q37Q	MRGPRF_uc001oop.3_Silent_p.Q37Q	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	37	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCATCGCGATCTGCTCGATGG	0.642													0	0	0	1	0	11	31										T	68773667	C	T	68773667	2	4	83	1	0	0	0	0	0	0	0	1	9765	912	32	1		1	MRGPRF	11	68773667	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	743892	68773667	66232849	276	25120										
PRKRIR	5612	broad.mit.edu	37	chr11	76066699	76066699	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtcctgatttcatcttcactCtaaatgtcaagaaaaaaaaa	4	8	5	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:76066699C>G	uc001oxh.1	-	4	319	c.319_splice	c.e4-1	p.S107_splice	PRKRIR_uc010rrz.1_5'UTR	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double						negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CATCTTCACTCTAAATGTCAA	0.323													0	0	0	1	0	3	8										G	76066699	C	G	76066699	5	3	83	1	0	0	0	0	0	0	1	0	12526	927	32	1	1975	1	PRKRIR	11	76066699	Splice_Site	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7293032	76066699	58939817	277	25121										
CAPN5	726	broad.mit.edu	37	chr11	76795973	76795973	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctatgaggaccagaactactCagccctgaggcgggactgcc	12	13	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:76795973C>T	uc001oxx.2	+	2	226	c.41C>T	c.(40-42)TCA>TTA	p.S14L	CAPN5_uc009yup.2_Missense_Mutation_p.S14L|CAPN5_uc009yuq.2_Missense_Mutation_p.S50L|CAPN5_uc001oxy.2_Missense_Mutation_p.S54L	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	14					proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						CAGAACTACTCAGCCCTGAGG	0.637													0	0	0	1	0	11	31										T	76795973	C	T	76795973	3	4	83	1	0	0	0	0	1	0	0	0	2629	838	29	1	43	1	CAPN5	11	76795973	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	729274	76795973	58210543	278	25122										
EED	8726	broad.mit.edu	37	chr11	85977176	85977176	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cctgtggtatggatcattctCttaaactttggaggatcaat	9	7	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:85977176C>T	uc001pbp.2	+	8	1235	c.778C>T	c.(778-780)CTT>TTT	p.L260F	EED_uc010rtm.1_Missense_Mutation_p.L260F|EED_uc001pbq.2_Missense_Mutation_p.L260F|EED_uc001pbr.2_Missense_Mutation_p.L260F|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	260	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GGATCATTCTCTTAAACTTTG	0.289													0	0	0	1	0	53	101										T	85977176	C	T	85977176	3	4	83	1	0	0	0	0	1	0	0	0	4922	913	32	1	808	1	EED	11	85977176	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	9181203	85977176	49029340	279	25123										
MAML2	84441	broad.mit.edu	37	chr11	96074933	96074933	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttggcggcagacagcgatccGagcccggaggcgctccacga	15	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:96074933G>C	uc001pfw.1	-	1	1412	c.127C>G	c.(127-129)CGG>GGG	p.R43G		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	43					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				ACAGCGATCCGAGCCCGGAGG	0.657			T	MECT1|CRTC3	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	6	9										C	96074933	G	C	96074933	3	2	83	1	0	0	0	0	1	0	0	0	9206	1057	37	1	3363	1	MAML2	11	96074933	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	10097757	96074933	38931583	280	25124										
MAML2	84441	broad.mit.edu	37	chr11	96074994	96074994	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtgactgagccccctccaagGagccccgccccagaggcccc	11	20	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:96074994G>C	uc001pfw.1	-	1	1351	c.66C>G	c.(64-66)CTC>CTG	p.L22L		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	22					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCCCTCCAAGGAGCCCCGCCC	0.682			T	MECT1|CRTC3	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	3										C	96074994	G	C	96074994	2	2	83	1	0	0	0	0	0	0	0	1	9206	1161	41	1		1	MAML2	11	96074994	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	61	96074994	38931522	281	25125										
YAP1	10413	broad.mit.edu	37	chr11	102098267	102098267	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgagcagctacagtgtccctCgaaccccagatgacttcctg	9	14	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:102098267C>T	uc001pgt.2	+	8	1601	c.1231C>T	c.(1231-1233)CGA>TGA	p.R411*	YAP1_uc001pgs.2_Nonsense_Mutation_p.R361*|YAP1_uc001pgu.2_Nonsense_Mutation_p.R395*|YAP1_uc001pgv.2_Nonsense_Mutation_p.R357*|YAP1_uc010ruo.1_Nonsense_Mutation_p.R233*|YAP1_uc001pgw.2_Nonsense_Mutation_p.R235*|YAP1_uc010rup.1_Nonsense_Mutation_p.R176*	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	411	Transactivation domain.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		CAGTGTCCCTCGAACCCCAGA	0.433													0	0	0	1	0	8	17										T	102098267	C	T	102098267	4	4	83	1	0	0	0	0	0	1	0	0	17463	876	31	1	1273	1	YAP1	11	102098267	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6023273	102098267	32908249	282	25126										
LAYN	143903	broad.mit.edu	37	chr11	111430885	111430885	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctggccctctcctcaccaggGaaacagcccggacctagagg	11	16	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:111430885G>A	uc001plr.1	+	8	1187	c.851G>A	c.(850-852)GGA>GAA	p.G284E	LAYN_uc001plp.1_Missense_Mutation_p.G276E|LAYN_uc001plq.1_3'UTR|LAYN_uc001pls.1_3'UTR|LAYN_uc010rwg.1_Missense_Mutation_p.G131E|LAYN_uc010rwh.1_Missense_Mutation_p.G132E	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	284	Cytoplasmic (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		CCTCACCAGGGAAACAGCCCG	0.498													0	0	0	1	0	13	48										A	111430885	G	A	111430885	3	1	83	1	0	0	0	0	1	0	0	0	8649	1174	41	1	853	1	LAYN	11	111430885	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	9332618	111430885	23575631	283	25127										
OR10S1	219873	broad.mit.edu	37	chr11	123847570	123847570	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agctcctgcctcactggagcGaggctgcaggtagatacaga	13	11	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:123847570G>A	uc001pzm.1	-	1	829	c.829C>T	c.(829-831)CGC>TGC	p.R277C		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	277	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCACTGGAGCGAGGCTGCAGG	0.592													0	0	0	1	0	30	72										A	123847570	G	A	123847570	3	1	83	1	0	0	0	0	1	0	0	0	10918	1058	37	1	170	1	OR10S1	11	123847570	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	12416685	123847570	11158946	284	25128										
KIRREL3	84623	broad.mit.edu	37	chr11	126318913	126318913	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actgcactcacagtagacgtCaaccgtgcggctgaggttgg	13	11	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:126318913C>G	uc001qea.2	-	8	1349	c.988G>C	c.(988-990)GAC>CAC	p.D330H	KIRREL3_uc001qeb.2_Missense_Mutation_p.D330H|KIRREL3_uc001qec.1_Missense_Mutation_p.D330H	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	330	Extracellular (Potential).|Ig-like C2-type 3.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CAGTAGACGTCAACCGTGCGG	0.577													0	0	0	1	0	12	30										G	126318913	C	G	126318913	3	3	83	1	0	0	0	0	1	0	0	0	8326	826	29	1	1495	1	KIRREL3	11	126318913	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2471343	126318913	8687603	285	25129										
CD163L1	283316	broad.mit.edu	37	chr12	7526237	7526237	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gagcctcaaggctgtgaattCtacagagaaatacaaaactt	8	8	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:7526237C>T	uc001qsy.2	-	14	3436	c.3410_splice	c.e14-1	p.E1137_splice	CD163L1_uc010sge.1_Splice_Site_p.E1147_splice	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GCTGTGAATTCTACAGAGAAA	0.438													0	0	0	1	0	7	118										T	7526237	C	T	7526237	5	4	83	1	0	0	0	0	0	0	1	0	2968	927	32	1	976	1	CD163L1	12	7526237	Splice_Site	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		7526237	126325658	286	25130										
A2M	2	broad.mit.edu	37	chr12	9225252	9225252	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgcccaagagtctcacctgGaggtagacacatccttctcc	8	15	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:9225252G>C	uc001qvk.1	-	30	4085	c.3972C>G	c.(3970-3972)CTC>CTG	p.L1324L	A2M_uc001qvj.1_Silent_p.L366L|A2M_uc009zgk.1_Silent_p.L1174L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1324					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GTCTCACCTGGAGGTAGACAC	0.507													0	0	0	1	0	50	47										C	9225252	G	C	9225252	2	2	83	1	0	0	0	0	0	0	0	1	4	1161	41	1		1	A2M	12	9225252	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1699015	9225252	124626643	287	25131										
KLRC3	3823	broad.mit.edu	37	chr12	10587089	10587089	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaaaataaaaatgtacctttCtgcgttcttgtattcgggga	9	6	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:10587089C>T	uc001qyh.2	-	3	334	c.327G>A	c.(325-327)CAG>CAA	p.Q109Q	KLRC2_uc010she.1_Silent_p.Q109Q|KLRC2_uc001qyk.2_Silent_p.Q109Q	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	109	Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ATGTACCTTTCTGCGTTCTTG	0.279													0	0	0	1	0	13	100										T	10587089	C	T	10587089	2	4	83	1	0	0	0	0	0	0	0	1	8417	912	32	1		1	KLRC3	12	10587089	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1361837	10587089	123264806	288	25132										
CDKN1B	1027	broad.mit.edu	37	chr12	12871794	12871794	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acaaaagagccaacagaacaGaagaaaatgtttcagacggt	9	7	1	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:12871794G>T	uc001rat.2	+	2	983	c.511G>T	c.(511-513)GAA>TAA	p.E171*		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	171					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CAACAGAACAGAAGAAAATGT	0.443									Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				1	0	8.28887e-21	1	8.74467e-21	54	47										T	12871794	G	T	12871794	4	4	83	1	0	0	0	0	0	1	0	0	3159	943	33	3	517	3	CDKN1B	12	12871794	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2284705	12871794	120980101	289	25133										
SLC11A2	4891	broad.mit.edu	37	chr12	51389481	51389481	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acaaagacattgatgatgaaGgaaacaaagagtgcaatgca	10	5	0	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:51389481G>C	uc001rxe.3	-	10	1018	c.921C>G	c.(919-921)TCC>TCG	p.S307S	SLC11A2_uc001rxd.3_Silent_p.S156S|SLC11A2_uc001rxc.3_Silent_p.S307S|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_5'Flank|SLC11A2_uc010smx.1_Silent_p.S303S|SLC11A2_uc001rxh.1_Silent_p.S307S|SLC11A2_uc001rxj.1_Silent_p.S307S|SLC11A2_uc001rxi.2_Silent_p.S307S|SLC11A2_uc001rxk.1_Silent_p.S336S|SLC11A2_uc010smy.1_Silent_p.S270S	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	307	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						TGATGATGAAGGAAACAAAGA	0.413													0	0	0	1	0	22	29										C	51389481	G	C	51389481	2	2	83	1	0	0	0	0	0	0	0	1	14381	987	35	4		4	SLC11A2	12	51389481	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	38517687	51389481	82462414	290	25134										
KRT8	3856	broad.mit.edu	37	chr12	53292539	53292539	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cagcttgacgttcatcagctCctggtactcacgcagctgcc	9	15	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:53292539C>A	uc001sbd.2	-	6	1229	c.1126G>T	c.(1126-1128)GAG>TAG	p.E376*	KRT8_uc009zmj.2_Intron|KRT8_uc009zmk.1_Nonsense_Mutation_p.E404*|KRT8_uc009zml.1_Nonsense_Mutation_p.E376*|KRT8_uc009zmm.1_Nonsense_Mutation_p.E376*	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	376	Necessary for interaction with PNN.|Rod.|Coil 2.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCATCAGCTCCTGGTACTCA	0.642													1	0	7.63091e-17	1	8.00164e-17	40	51										A	53292539	C	A	53292539	4	1	83	1	0	0	0	0	0	1	0	0	8493	864	30	3	337	3	KRT8	12	53292539	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1903058	53292539	80559356	291	25135										
ESPL1	9700	broad.mit.edu	37	chr12	53677939	53677939	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agcaggttctgttcttgcttGagtcttgcacaggtgagcag	13	8	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:53677939G>C	uc001sck.2	+	17	3266	c.3175G>C	c.(3175-3177)GAG>CAG	p.E1059Q	ESPL1_uc001scj.2_Missense_Mutation_p.E734Q|ESPL1_uc010soe.1_Missense_Mutation_p.E270Q	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1059					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GTTCTTGCTTGAGTCTTGCAC	0.527													0	0	0	1	0	32	52										C	53677939	G	C	53677939	3	2	83	1	0	0	0	0	1	0	0	0	5253	1291	45	1	3237	1	ESPL1	12	53677939	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	385400	53677939	80173956	292	25136										
OR6C65	403282	broad.mit.edu	37	chr12	55794872	55794872	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccctatgctgctgattgcttGcacagacacacagtttctag	8	12	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:55794872G>C	uc010spl.1	+	1	560	c.560G>C	c.(559-561)TGC>TCC	p.C187S		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGATTGCTTGCACAGACACA	0.448													0	0	0	1	0	74	105										C	55794872	G	C	55794872	3	2	83	1	0	0	0	0	1	0	0	0	11195	1319	46	4	562	4	OR6C65	12	55794872	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2116933	55794872	78057023	293	25137										
ANKRD52	283373	broad.mit.edu	37	chr12	56645860	56645860	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcttcggcatcatggctggAaggtgtatggggttccgctc	14	10	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:56645860A>G	uc001skm.3	-	15	1621	c.1531T>C	c.(1531-1533)TCC>CCC	p.S511P		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	511	ANK 15.						protein binding			ovary(2)	2						TCATGGCTGGAAGGTGTATGG	0.592													0	0	0	1	0	5	35										G	56645860	A	G	56645860	3	3	83	1	0	0	0	0	1	0	0	0	678	246	9	5	1755	5	ANKRD52	12	56645860	Missense_Mutation	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	850988	56645860	77206035	294	25138										
LEMD3	23592	broad.mit.edu	37	chr12	65563434	65563434	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cggatgaggagcttttctctCagctccgccgttacggcctg	12	13	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:65563434C>G	uc001ssl.1	+	1	64	c.58C>G	c.(58-60)CAG>GAG	p.Q20E	LEMD3_uc009zqo.1_Missense_Mutation_p.Q20E	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	20	LEM.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GCTTTTCTCTCAGCTCCGCCG	0.602													0	0	0	1	0	2	4										G	65563434	C	G	65563434	3	3	83	1	0	0	0	0	1	0	0	0	8721	827	29	1	60	1	LEMD3	12	65563434	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	8917574	65563434	68288461	295	25139										
C12orf74	338809	broad.mit.edu	37	chr12	93100662	93100662	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggcttcccatgttacctttcGaagagcctgccaggaagccc	10	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:93100662G>A	uc001tch.1	+	2	485	c.255G>A	c.(253-255)TCG>TCA	p.S85S	C12orf74_uc001tci.2_Silent_p.S85S	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	85											0						GTTACCTTTCGAAGAGCCTGC	0.567													0	0	0	1	0	14	41										A	93100662	G	A	93100662	2	1	83	1	0	0	0	0	0	0	0	1	1714	1045	37	1		1	C12orf74	12	93100662	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	27537228	93100662	40751233	296	25140										
ANKRD13A	88455	broad.mit.edu	37	chr12	110468561	110468561	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggaagggacccaggctgattCaggtaaaaaaataaataaat	10	5	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:110468561C>T	uc001tpx.2	+	12	1605	c.1346C>T	c.(1345-1347)TCA>TTA	p.S449L	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc010sxw.1_Missense_Mutation_p.S448L|ANKRD13A_uc001tpy.2_Intron|ANKRD13A_uc001tpz.2_Missense_Mutation_p.S87L|ANKRD13A_uc001tqa.2_Missense_Mutation_p.S87L	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	449											0						CAGGCTGATTCAGGtaaaaaa	0.219													0	0	0	1	0	7	8										T	110468561	C	T	110468561	3	4	83	1	0	0	0	0	1	0	0	0	641	838	29	1	1392	1	ANKRD13A	12	110468561	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	17367899	110468561	23383334	297	25141										
CCDC63	160762	broad.mit.edu	37	chr12	111296402	111296402	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccaacagcaaggagatcaaGaccctgaagacagagcagga	11	10	1	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:111296402G>C	uc001trv.1	+	4	387	c.192G>C	c.(190-192)AAG>AAC	p.K64N	CCDC63_uc009zvt.1_5'UTR|CCDC63_uc010sye.1_Missense_Mutation_p.K24N|CCDC63_uc001trw.1_5'UTR	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	64	Potential.									skin(6)|ovary(1)|pancreas(1)	8						AGGAGATCAAGACCCTGAAGA	0.502													0	0	0	1	0	7	19										C	111296402	G	C	111296402	3	2	83	1	0	0	0	0	1	0	0	0	2834	933	33	1	202	1	CCDC63	12	111296402	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	827841	111296402	22555493	298	25142										
SBNO1	55206	broad.mit.edu	37	chr12	123789171	123789171	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcagcataaatttctaatttGagctgcttcccagtatttgg	7	8	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:123789171G>C	uc010tap.1	-	28	3726	c.3726C>G	c.(3724-3726)CTC>CTG	p.L1242L	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Silent_p.L1241L|SBNO1_uc010taq.1_Silent_p.L193L|SBNO1_uc001ues.1_Silent_p.L193L	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1242							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTCTAATTTGAGCTGCTTCC	0.259													0	0	0	1	0	7	20										C	123789171	G	C	123789171	2	2	83	1	0	0	0	0	0	0	0	1	13862	1277	45	1		1	SBNO1	12	123789171	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	12492769	123789171	10062724	299	25143										
GPR133	283383	broad.mit.edu	37	chr12	131471828	131471828	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgagaacggtgctttcgatGagttcatcatctgggagcgg	14	7	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:131471828G>A	uc001uit.3	+	6	1238	c.679G>A	c.(679-681)GAG>AAG	p.E227K	GPR133_uc010tbm.1_Missense_Mutation_p.E259K	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	227	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGCTTTCGATGAGTTCATCAT	0.542													0	0	0	1	0	14	44										A	131471828	G	A	131471828	3	1	83	1	0	0	0	0	1	0	0	0	6643	1291	45	1	701	1	GPR133	12	131471828	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	7682657	131471828	2380067	300	25144										
GOLGA3	2802	broad.mit.edu	37	chr12	133353621	133353621	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctggagctgtgcccgggcctCggccagctctgcttggaact	14	14	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:133353621C>T	uc001ukz.1	-	20	4337	c.3778G>A	c.(3778-3780)GAG>AAG	p.E1260K	GOLGA3_uc001ula.1_Missense_Mutation_p.E1260K	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1260	Potential.|Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCCCGGGCCTCGGCCAGCTCT	0.587													0	0	0	1	0	9	15										T	133353621	C	T	133353621	3	4	83	1	0	0	0	0	1	0	0	0	6554	893	31	1	738	1	GOLGA3	12	133353621	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1881793	133353621	498274	301	25145										
IFT88	8100	broad.mit.edu	37	chr13	21217598	21217598	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	actgacattgcataagatatGaattaatggaaaatcccagt	7	6	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:21217598G>A	uc001unh.2	+	21	2110	c.1714G>A	c.(1714-1716)GAA>AAA	p.E572K	IFT88_uc001uni.2_Missense_Mutation_p.E563K|IFT88_uc001unj.2_Missense_Mutation_p.E562K|IFT88_uc010tcq.1_Missense_Mutation_p.E543K	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	572	TPR 9.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CATAAGATATGAATTAATGGA	0.318													0	0	0	1	0	11	42										A	21217598	G	A	21217598	3	1	83	1	0	0	0	0	1	0	0	0	7566	1291	45	1	1788	1	IFT88	13	21217598	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		21217598	93952280	302	25146										
PARP4	143	broad.mit.edu	37	chr13	25016097	25016097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aatatcaggaaaaggcgactCattctcatcctatattgaat	6	8	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:25016097C>G	uc001upl.2	-	30	3659	c.3553G>C	c.(3553-3555)GAG>CAG	p.E1185Q		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1185					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AAAGGCGACTCATTCTCATCC	0.403													0	0	0	1	0	11	42										G	25016097	C	G	25016097	3	3	83	1	0	0	0	0	1	0	0	0	11463	835	29	1	1641	1	PARP4	13	25016097	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3798499	25016097	90153781	303	25147										
NUPL1	9818	broad.mit.edu	37	chr13	25876015	25876015	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctccttcggaacgggagcgtCtaggtaaccgcactttctcg	11	13	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:25876015C>T	uc001uqi.2	+	1	350	c.104C>T	c.(103-105)TCT>TTT	p.S35F	NUPL1_uc001uqg.1_Missense_Mutation_p.S35F|NUPL1_uc001uqj.2_Missense_Mutation_p.S35F	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	35	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		ACGGGAGCGTCTAGGTAACCG	0.662													0	0	0	1	0	5	9										T	25876015	C	T	25876015	3	4	83	1	0	0	0	0	1	0	0	0	10774	913	32	1	106	1	NUPL1	13	25876015	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	859918	25876015	89293863	304	25148										
LNX2	222484	broad.mit.edu	37	chr13	28127506	28127506	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggggacgcggcactggctttCagcattgcaactgcctcact	12	13	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:28127506C>T	uc001url.3	-	8	1926	c.1617G>A	c.(1615-1617)CTG>CTA	p.L539L	LNX2_uc001urm.1_Silent_p.L539L	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	539	PDZ 3.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CACTGGCTTTCAGCATTGCAA	0.478													0	0	0	1	0	15	52										T	28127506	C	T	28127506	2	4	83	1	0	0	0	0	0	0	0	1	8866	813	29	1		1	LNX2	13	28127506	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2251491	28127506	87042372	305	25149										
KATNAL1	84056	broad.mit.edu	37	chr13	30782761	30782761	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttagcaattttctttagggcCaattcaaagtctcctttggt	7	8	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:30782761C>T	uc001uss.2	-	11	1490	c.1389G>A	c.(1387-1389)TTG>TTA	p.L463L	KATNAL1_uc001ust.2_Silent_p.L463L	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	463						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		TCTTTAGGGCCAATTCAAAGT	0.418													0	0	0	1	0	24	55										T	30782761	C	T	30782761	2	4	83	1	0	0	0	0	0	0	0	1	7985	593	21	2		2	KATNAL1	13	30782761	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2655255	30782761	84387117	306	25150										
ZC3H13	23091	broad.mit.edu	37	chr13	46594682	46594682	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttccctatgtctccctcttGaagattctttctaaaaaagt	4	10	4	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:46594682G>C	uc010tfw.1	-	4	356	c.350C>G	c.(349-351)TCA>TGA	p.S117*	ZC3H13_uc001vas.1_Nonsense_Mutation_p.S117*|ZC3H13_uc001vat.1_Nonsense_Mutation_p.S117*	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	117							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTCCCTCTTGAAGATTCTTT	0.284													0	0	0	1	0	11	33										C	46594682	G	C	46594682	4	2	83	1	0	0	0	0	0	1	0	0	17562	1294	45	1	4396	1	ZC3H13	13	46594682	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	15811921	46594682	68575196	307	25151										
RB1	5925	broad.mit.edu	37	chr13	48936983	48936983	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tacccattaatggttcacctCgaacacccaggcgaggtcag	9	13	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:48936983C>T	uc001vcb.2	+	8	917	c.751C>T	c.(751-753)CGA>TGA	p.R251*	RB1_uc010acs.1_RNA|RB1_uc010act.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	251					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.R251*(3)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGTTCACCTCGAACACCCAG	0.343		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	1	0	17	46										T	48936983	C	T	48936983	4	4	83	1	0	0	0	0	0	1	0	0	13098	876	31	1	781	1	RB1	13	48936983	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2342301	48936983	66232895	308	25152										
SLITRK1	114798	broad.mit.edu	37	chr13	84454070	84454070	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccaggggtttccgtggaggtCtatctggatgatggaggtta	16	6	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:84454070C>G	uc001vlk.2	-	1	2459	c.1573G>C	c.(1573-1575)GAC>CAC	p.D525H		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	525	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCGTGGAGGTCTATCTGGATG	0.557													0	0	0	1	0	16	46										G	84454070	C	G	84454070	3	3	83	1	0	0	0	0	1	0	0	0	14742	913	32	1	521	1	SLITRK1	13	84454070	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	35517087	84454070	30715808	309	25153										
GPC5	2262	broad.mit.edu	37	chr13	92345940	92345940	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccttgtatgggatactgcctCaatgtcatgcgaggctgcct	11	11	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:92345940C>G	uc010tif.1	+	3	1191	c.825C>G	c.(823-825)CTC>CTG	p.L275L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	275						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GATACTGCCTCAATGTCATGC	0.547													0	0	0	1	0	5	73										G	92345940	C	G	92345940	2	3	83	1	0	0	0	0	0	0	0	1	6601	813	29	1		1	GPC5	13	92345940	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7891870	92345940	22823938	310	25154										
STK24	8428	broad.mit.edu	37	chr13	99114081	99114081	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccattctcgagattcttggGatctttttctcggattgtga	9	8	4	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:99114081G>A	uc001vnm.1	-	8	1271	c.1036C>T	c.(1036-1038)CCC>TCC	p.P346S	STK24_uc001vnn.1_Missense_Mutation_p.P334S|STK24_uc010tim.1_Missense_Mutation_p.P315S	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	346					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGATTCTTGGGATCTTTTTCT	0.507													0	0	0	1	0	33	74										A	99114081	G	A	99114081	3	1	83	1	0	0	0	0	1	0	0	0	15292	1174	41	1	311	1	STK24	13	99114081	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6768141	99114081	16055797	311	25155										
FAM155A	728215	broad.mit.edu	37	chr13	108518877	108518877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgaacggtttctcgttctctCggggtgctgccaaccagatt	11	11	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108518877C>T	uc001vql.2	-	1	584	c.68G>A	c.(67-69)CGA>CAA	p.R23Q		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	23						integral to membrane	binding			skin(1)	1						CTCGTTCTCTCGGGGTGCTGC	0.532													0	0	0	1	0	55	133										T	108518877	C	T	108518877	3	4	83	1	0	0	0	0	1	0	0	0	5465	884	31	1	1320	1	FAM155A	13	108518877	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	9404796	108518877	6651001	312	25156										
LIG4	3981	broad.mit.edu	37	chr13	108861843	108861843	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtcgtccagggtcatgcactCatgccactccttgtcatctc	8	15	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108861843C>T	uc001vqn.2	-	2	2047	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	LIG4_uc001vqo.2_Missense_Mutation_p.E592K|LIG4_uc010agg.1_Missense_Mutation_p.E525K|LIG4_uc010agf.2_Missense_Mutation_p.E592K|LIG4_uc001vqp.2_Missense_Mutation_p.E592K	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	592					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					GTCATGCACTCATGCCACTCC	0.448								NHEJ					0	0	0	1	0	21	49										T	108861843	C	T	108861843	3	4	83	1	0	0	0	0	1	0	0	0	8783	835	29	1	965	1	LIG4	13	108861843	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	342966	108861843	6308035	313	25157										
TNFSF13B	10673	broad.mit.edu	37	chr13	108959240	108959240	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagagaaaatgcacaaatatCactggatggagatgtcacat	9	6	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108959240C>T	uc001vqr.2	+	6	1079	c.812C>T	c.(811-813)TCA>TTA	p.S271L	TNFSF13B_uc010agj.2_Missense_Mutation_p.S252L	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	271	Extracellular (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			GCACAAATATCACTGGATGGA	0.393													0	0	0	1	0	15	38										T	108959240	C	T	108959240	3	4	83	1	0	0	0	0	1	0	0	0	16303	838	29	1	834	1	TNFSF13B	13	108959240	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	97397	108959240	6210638	314	25158										
NID2	22795	broad.mit.edu	37	chr14	52485839	52485839	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agtctgggtaccaggaacttCatgaccatcagggtccacgc	11	12	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:52485839C>T	uc001wzo.2	-	14	3202	c.2968G>A	c.(2968-2970)GAA>AAA	p.E990K	NID2_uc010tqs.1_Missense_Mutation_p.E942K|NID2_uc010tqt.1_Missense_Mutation_p.E990K|NID2_uc001wzp.2_Missense_Mutation_p.E990K	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	990	Thyroglobulin type-1 1.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CCAGGAACTTCATGACCATCA	0.602													0	0	0	1	0	8	22										T	52485839	C	T	52485839	3	4	83	1	0	0	0	0	1	0	0	0	10415	835	29	1	1195	1	NID2	14	52485839	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		52485839	54863701	315	25159										
FUT8	2530	broad.mit.edu	37	chr14	66209049	66209049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caacaggaaattgggaaggaCgggcctatatccctcctaca	10	11	0	0	rs149328619	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:66209049C>T	uc001xin.2	+	11	2846	c.1649C>T	c.(1648-1650)ACG>ATG	p.T550M	FUT8_uc001xio.2_Missense_Mutation_p.T550M|FUT8_uc010tsp.1_Missense_Mutation_p.T387M|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.T550M|FUT8_uc001xiq.2_Missense_Mutation_p.T421M|FUT8_uc001xis.2_Missense_Mutation_p.T144M	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	550	SH3.|Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TTGGGAAGGACGGGCCTATAT	0.443													0	0	0	1	0	15	79										T	66209049	C	T	66209049	3	4	83	1	0	0	0	0	1	0	0	0	6110	536	19	2	1782	2	FUT8	14	66209049	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	13723210	66209049	41140491	316	25160										
KIAA0317	9870	broad.mit.edu	37	chr14	75143291	75143291	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agggagactgcttacctcatGaatggacaaggtgtaattgt	12	6	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:75143291G>A	uc001xqb.2	-	6	1151	c.646C>T	c.(646-648)CAT>TAT	p.H216Y	KIAA0317_uc010tut.1_Missense_Mutation_p.H55Y|KIAA0317_uc001xqc.2_Missense_Mutation_p.H216Y	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	216					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		CTTACCTCATGAATGGACAAG	0.453													0	0	0	1	0	23	113										A	75143291	G	A	75143291	3	1	83	1	0	0	0	0	1	0	0	0	8167	1290	45	1	1885	1	KIAA0317	14	75143291	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8934242	75143291	32206249	317	25161										
CCDC88C	440193	broad.mit.edu	37	chr14	91805717	91805717	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gagaggctgctggtggggctGggagtggagtcggcgctgga	23	6	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:91805717G>A	uc010aty.2	-	8	813	c.714C>T	c.(712-714)CCC>CCT	p.P238P	CCDC88C_uc010twk.1_Silent_p.P202P	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	238					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TGGTGGGGCTGGGAGTGGAGT	0.662													0	0	0	1	0	4	18										A	91805717	G	A	91805717	2	1	83	1	0	0	0	0	0	0	0	1	2865	1335	47	2		2	CCDC88C	14	91805717	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	16662426	91805717	15543823	318	25162										
TDRD9	122402	broad.mit.edu	37	chr14	104488586	104488586	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gatgtctcaactaaaagtttCacttgaactcagcgttcatt	6	9	4	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:104488586C>T	uc001yom.3	+	24	2555	c.2525C>T	c.(2524-2526)TCA>TTA	p.S842L	TDRD9_uc001yon.3_Missense_Mutation_p.S580L	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	842					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CTAAAAGTTTCACTTGAACTC	0.428													0	0	0	1	0	6	16										T	104488586	C	T	104488586	3	4	83	1	0	0	0	0	1	0	0	0	15733	838	29	1	2619	1	TDRD9	14	104488586	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	12682869	104488586	2860954	319	25163										
NIPA1	123606	broad.mit.edu	37	chr15	23049167	23049167	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgactggacgggttgttatGcaagatgtcttgggccgcca	14	9	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:23049167G>A	uc001yvc.2	-	5	677	c.652C>T	c.(652-654)CAT>TAT	p.H218Y	NIPA1_uc001yvd.2_Missense_Mutation_p.H48Y|NIPA1_uc001yve.2_Missense_Mutation_p.H143Y	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	218	Extracellular (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		GGGTTGTTATGCAAGATGTCT	0.587													0	0	0	1	0	18	43										A	23049167	G	A	23049167	3	1	83	1	0	0	0	0	1	0	0	0	10422	1319	46	2	341	2	NIPA1	15	23049167	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		23049167	79482225	320	25164										
UBE3A	7337	broad.mit.edu	37	chr15	25616710	25616710	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccttgaggaagatgcttctGagtcttcttccatagcagca	9	10	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:25616710G>C	uc001zaq.2	-	4	620	c.620C>G	c.(619-621)TCA>TGA	p.S207*	uc001zae.2_Intron|UBE3A_uc001zar.2_Nonsense_Mutation_p.S184*|UBE3A_uc001zas.2_Nonsense_Mutation_p.S204*|UBE3A_uc001zat.2_Nonsense_Mutation_p.S184*	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	207					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		AGATGCTTCTGAGTCTTCTTC	0.408													0	0	0	1	0	45	141										C	25616710	G	C	25616710	4	2	83	1	0	0	0	0	0	1	0	0	16876	1294	45	1	2039	1	UBE3A	15	25616710	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2567543	25616710	76914682	321	25165										
TJP1	7082	broad.mit.edu	37	chr15	30064302	30064302	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cccacttttccttagttgctGaacagcaaaagcatgttcaa	6	11	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:30064302G>A	uc001zcr.2	-	4	752	c.277C>T	c.(277-279)CAG>TAG	p.Q93*	TJP1_uc010azl.2_Nonsense_Mutation_p.Q81*|TJP1_uc001zcq.2_Nonsense_Mutation_p.Q97*|TJP1_uc001zcs.2_Nonsense_Mutation_p.Q93*	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	93	PDZ 1.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTAGTTGCTGAACAGCAAAA	0.348													0	0	0	1	0	12	29										A	30064302	G	A	30064302	4	1	83	1	0	0	0	0	0	1	0	0	15926	1299	45	1	5069	1	TJP1	15	30064302	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4447592	30064302	72467090	322	25166										
RYR3	6263	broad.mit.edu	37	chr15	34064217	34064217	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gagaagacttcagaaaacctGaaacttgggaagttcaccca	9	9	2	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:34064217G>A	uc001zhi.2	+	63	8983	c.8913G>A	c.(8911-8913)CTG>CTA	p.L2971L	RYR3_uc010bar.2_Silent_p.L2971L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2971	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGAAAACCTGAAACTTGGGA	0.473													0	0	0	1	0	5	16										A	34064217	G	A	34064217	2	1	83	1	0	0	0	0	0	0	0	1	13770	1277	45	1		1	RYR3	15	34064217	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3999915	34064217	68467175	323	25167										
CAPN3	825	broad.mit.edu	37	chr15	42703108	42703108	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acctcaacaaccagctctatGacatcattaccatgcggtac	5	14	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:42703108G>C	uc001zpn.1	+	22	2596	c.2290G>C	c.(2290-2292)GAC>CAC	p.D764H	CAPN3_uc001zpk.1_Missense_Mutation_p.D531H|CAPN3_uc001zpl.1_Missense_Mutation_p.D671H|CAPN3_uc010udf.1_Missense_Mutation_p.D677H|CAPN3_uc010udg.1_Missense_Mutation_p.D629H|CAPN3_uc001zpo.1_Missense_Mutation_p.D758H|CAPN3_uc001zpp.1_Missense_Mutation_p.D672H|CAPN3_uc001zpq.1_Missense_Mutation_p.D252H|CAPN3_uc010bcv.1_Missense_Mutation_p.D99H|CAPN3_uc001zpr.1_Missense_Mutation_p.D99H|CAPN3_uc001zps.1_Missense_Mutation_p.D99H|CAPN3_uc001zpt.1_Missense_Mutation_p.D99H	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	764	Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CCAGCTCTATGACATCATTAC	0.517													0	0	0	1	0	20	49										C	42703108	G	C	42703108	3	2	83	1	0	0	0	0	1	0	0	0	2628	1290	45	1	2428	1	CAPN3	15	42703108	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	8638891	42703108	59828284	324	25168										
UBR1	197131	broad.mit.edu	37	chr15	43294862	43294862	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caagtcaaaaaggtcaacatGaatgcgctgctgagagctca	10	9	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:43294862G>A	uc001zqq.2	-	32	3616	c.3550C>T	c.(3550-3552)CAT>TAT	p.H1184Y		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1184	RING-type; atypical.				cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGGTCAACATGAATGCGCTGC	0.413													0	0	0	1	0	13	44										A	43294862	G	A	43294862	3	1	83	1	0	0	0	0	1	0	0	0	16898	1290	45	1	1763	1	UBR1	15	43294862	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	591754	43294862	59236530	325	25169										
PLDN	26258	broad.mit.edu	37	chr15	45884353	45884353	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtttaagtgacacttctccaGatgaagggttaatagaggac	11	6	1	4	rs149605903		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:45884353G>A	uc001zvq.2	+	2	328	c.103G>A	c.(103-105)GAT>AAT	p.D35N	PLDN_uc001zvr.2_RNA|PLDN_uc001zvs.2_RNA	NM_012388	NP_036520	Q9UL45	PLDN_HUMAN	pallidin	35					post-Golgi vesicle-mediated transport|synaptic vesicle docking involved in exocytosis	BLOC-1 complex|endomembrane system|membrane	identical protein binding|syntaxin-13 binding			skin(1)	1		Lung NSC(122;1.6e-06)|all_lung(180;1.13e-05)|Melanoma(134;0.027)		all cancers(107;6.58e-18)|GBM - Glioblastoma multiforme(94;5.91e-07)		CACTTCTCCAGATGAAGGGTT	0.313													0	0	0	1	0	15	38										A	45884353	G	A	45884353	3	1	83	1	0	0	0	0	1	0	0	0	12051	942	33	1	109	1	PLDN	15	45884353	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2589491	45884353	56647039	326	25170										
CEP152	22995	broad.mit.edu	37	chr15	49048212	49048212	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcacagacatccattttgaaGaacaagtcgacatgatttcc	7	10	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:49048212G>A	uc001zwy.2	-	20	3267	c.3233C>T	c.(3232-3234)TCT>TTT	p.S1078F	CEP152_uc001zwz.2_Missense_Mutation_p.S1078F|CEP152_uc001zxa.1_Missense_Mutation_p.S985F	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1078					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCATTTTGAAGAACAAGTCGA	0.408													0	0	0	1	0	41	99										A	49048212	G	A	49048212	3	1	83	1	0	0	0	0	1	0	0	0	3248	942	33	1	1759	1	CEP152	15	49048212	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3163859	49048212	53483180	327	25171										
TLN2	83660	broad.mit.edu	37	chr15	63029226	63029226	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gctccgccatgctcattcaaGaggccaagcaggccctgatt	10	14	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:63029226G>C	uc002alb.3	+	26	3508	c.3508G>C	c.(3508-3510)GAG>CAG	p.E1170Q		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1170	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GCTCATTCAAGAGGCCAAGCA	0.577													0	0	0	1	0	14	41										C	63029226	G	C	63029226	3	2	83	1	0	0	0	0	1	0	0	0	15945	943	33	1	3610	1	TLN2	15	63029226	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	13981014	63029226	39502166	328	25172										
DENND4A	10260	broad.mit.edu	37	chr15	65983618	65983618	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aaagaatttttgcatcagctCccaatttttcaactatatct	3	9	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:65983618C>T	uc002aph.2	-	22	3560	c.3182G>A	c.(3181-3183)GGA>GAA	p.G1061E	DENND4A_uc002api.2_Missense_Mutation_p.G1104E|DENND4A_uc002apj.3_Missense_Mutation_p.G1061E	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1061					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGCATCAGCTCCCAATTTTTC	0.378													0	0	0	1	0	5	31										T	65983618	C	T	65983618	3	4	83	1	0	0	0	0	1	0	0	0	4433	855	30	1	2453	1	DENND4A	15	65983618	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2954392	65983618	36547774	329	25173										
KIF23	9493	broad.mit.edu	37	chr15	69721528	69721528	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaactaaccggaccagagcaGaagggaacagattacgtgaa	12	8	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:69721528G>A	uc002asb.2	+	10	1165	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	KIF23_uc002asc.2_Missense_Mutation_p.E350K|KIF23_uc010bii.2_Missense_Mutation_p.E240K|KIF23_uc010ukc.1_Missense_Mutation_p.E167K|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	350	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						GACCAGAGCAGAAGGGAACAG	0.368													0	0	0	1	0	13	16										A	69721528	G	A	69721528	3	1	83	1	0	0	0	0	1	0	0	0	8291	943	33	1	1086	1	KIF23	15	69721528	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3737910	69721528	32809864	330	25174										
KIF23	9493	broad.mit.edu	37	chr15	69737198	69737198	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacgatcacgctctgcaggaGacagatgggtagatcataag	13	8	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:69737198G>A	uc002asb.2	+	19	2566	c.2449G>A	c.(2449-2451)GAC>AAC	p.D817N	KIF23_uc002asc.2_Missense_Mutation_p.D713N|KIF23_uc010bii.2_Intron|KIF23_uc010ukc.1_Missense_Mutation_p.D530N	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	817					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						CTCTGCAGGAGACAGATGGGT	0.453													0	0	0	1	0	10	65										A	69737198	G	A	69737198	3	1	83	1	0	0	0	0	1	0	0	0	8291	942	33	1	2523	1	KIF23	15	69737198	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	15670	69737198	32794194	331	25175										
BBS4	585	broad.mit.edu	37	chr15	73004593	73004593	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccctctttcaggctgttatCaaagaacagcttcaagagac	7	11	4	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:73004593C>G	uc002avb.2	+	4	208	c.165C>G	c.(163-165)ATC>ATG	p.I55M	BBS4_uc010ukv.1_Missense_Mutation_p.I43M|BBS4_uc002avc.2_Translation_Start_Site|BBS4_uc002avd.2_Missense_Mutation_p.I63M	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	55	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						AGGCTGTTATCAAAGAACAGC	0.358									Bardet-Biedl_syndrome				0	0	0	1	0	6	25										G	73004593	C	G	73004593	3	3	83	1	0	0	0	0	1	0	0	0	1339	816	29	1	179	1	BBS4	15	73004593	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3267395	73004593	29526799	332	25176										
C15orf42	90381	broad.mit.edu	37	chr15	90119340	90119340	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgcagttcgtgtctgggtgcGaggcccaggcccagcgcctg	16	13	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:90119340G>A	uc002boe.2	+	1	523	c.523G>A	c.(523-525)GAG>AAG	p.E175K		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	175					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTCTGGGTGCGAGGCCCAGGC	0.662													0	0	0	1	0	6	19										A	90119340	G	A	90119340	3	1	83	1	0	0	0	0	1	0	0	0	1796	1059	37	1	525	1	C15orf42	15	90119340	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	17114747	90119340	12412052	333	25177										
FLYWCH1	84256	broad.mit.edu	37	chr16	2983500	2983500	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tctcaccaggcctcggcccaGaaagcgagcaaaggtcgaag	12	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:2983500G>A	uc002csd.2	+	5	1529	c.1166G>A	c.(1165-1167)AGA>AAA	p.R389K	FLYWCH1_uc002csb.2_Missense_Mutation_p.R388K|FLYWCH1_uc002csc.2_Missense_Mutation_p.R388K|FLYWCH1_uc010bsv.2_Missense_Mutation_p.R64K	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	389						nucleus	DNA binding|metal ion binding				0						CCTCGGCCCAGAAAGCGAGCA	0.657													0	0	0	1	0	5	8										A	2983500	G	A	2983500	3	1	83	1	0	0	0	0	1	0	0	0	5947	942	33	1	1173	1	FLYWCH1	16	2983500	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		2983500	87371253	334	25178										
POLR3E	55718	broad.mit.edu	37	chr16	22319516	22319516	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tacgatgacattccgcacctCtcagccaagatcaagcccaa	6	15	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:22319516C>G	uc002dkk.2	+	4	291	c.135C>G	c.(133-135)CTC>CTG	p.L45L	POLR3E_uc002dkj.1_Silent_p.L45L|POLR3E_uc002dkm.2_Silent_p.L9L|POLR3E_uc010vbr.1_Silent_p.L45L|POLR3E_uc002dkl.2_Silent_p.L45L|POLR3E_uc010vbs.1_Intron|POLR3E_uc010vbt.1_Missense_Mutation_p.S6C	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	45					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		TTCCGCACCTCTCAGCCAAGA	0.627													0	0	0	1	0	10	43										G	22319516	C	G	22319516	2	3	83	1	0	0	0	0	0	0	0	1	12232	900	32	1		1	POLR3E	16	22319516	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	19336016	22319516	68035237	335	25179										
ERN2	10595	broad.mit.edu	37	chr16	23713758	23713758	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccacactgcctgaggggtatCtaacagcagtgctgggtgag	14	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:23713758C>G	uc002dma.3	-	10	1347	c.1178G>C	c.(1177-1179)AGA>ACA	p.R393T	ERN2_uc010bxp.2_Missense_Mutation_p.R393T|ERN2_uc010bxq.1_Missense_Mutation_p.R201T	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	345	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGAGGGGTATCTAACAGCAGT	0.582													0	0	0	1	0	52	124										G	23713758	C	G	23713758	3	3	83	1	0	0	0	0	1	0	0	0	5238	913	32	1	1798	1	ERN2	16	23713758	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1394242	23713758	66640995	336	25180										
ITGAL	3683	broad.mit.edu	37	chr16	30506048	30506048	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccacagattggctcttatttCggtggggagctgtgtggcgt	15	8	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:30506048C>T	uc002dyi.3	+	13	1556	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F	ITGAL_uc002dyj.3_Silent_p.F377F|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	460	FG-GAP 5.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GCTCTTATTTCGGTGGGGAGC	0.423													0	0	0	1	0	12	27										T	30506048	C	T	30506048	2	4	83	1	0	0	0	0	0	0	0	1	7886	883	31	1		1	ITGAL	16	30506048	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6792290	30506048	59848705	337	25181										
PHKG2	5261	broad.mit.edu	37	chr16	30767535	30767535	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccccagggtatctagcgccaGagatccttaaatgctccatg	9	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:30767535G>C	uc002dzk.1	+	7	682	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	PHKG2_uc002dzi.1_Missense_Mutation_p.E197Q|PHKG2_uc002dzj.1_Missense_Mutation_p.E95Q	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	197	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			TCTAGCGCCAGAGATCCTTAA	0.587													0	0	0	1	0	36	115										C	30767535	G	C	30767535	3	2	83	1	0	0	0	0	1	0	0	0	11847	943	33	1	611	1	PHKG2	16	30767535	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	261487	30767535	59587218	338	25182										
CHST6	4166	broad.mit.edu	37	chr16	75513367	75513367	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cggctcacggcccactggaaGaggtcggacaggttgcggcg	17	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:75513367G>C	uc002fef.2	-	3	540	c.360C>G	c.(358-360)CTC>CTG	p.L120L	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.L120L	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	120	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CCCACTGGAAGAGGTCGGACA	0.662													0	0	0	1	0	23	31										C	75513367	G	C	75513367	2	2	83	1	0	0	0	0	0	0	0	1	3408	929	33	1		1	CHST6	16	75513367	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	44745832	75513367	14841386	339	25183										
ADAMTS18	170692	broad.mit.edu	37	chr16	77375607	77375607	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agtatgcagtttaccatactCaagccacaaacggtcccttc	6	13	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:77375607C>G	uc002ffc.3	-	11	2123	c.1704G>C	c.(1702-1704)TTG>TTC	p.L568F	ADAMTS18_uc010chc.1_Missense_Mutation_p.L156F|ADAMTS18_uc002ffe.1_Missense_Mutation_p.L264F	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	568	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TTACCATACTCAAGCCACAAA	0.418													0	0	0	1	0	6	17										G	77375607	C	G	77375607	3	3	83	1	0	0	0	0	1	0	0	0	263	825	29	1	2013	1	ADAMTS18	16	77375607	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1862240	77375607	12979146	340	25184										
RPA1	6117	broad.mit.edu	37	chr17	1747276	1747276	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgactgctcatgagtgatggAttgaacactctatcctgtga	10	9	2	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:1747276A>T	uc002fto.2	+	3	262	c.147A>T	c.(145-147)GGA>GGT	p.G49G		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	49					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TGAGTGATGGATTGAACACTC	0.443								NER					0	0	0	1	0	10	43										T	1747276	A	T	1747276	2	4	83	1	0	0	0	0	0	0	0	1	13536	320	12	5		5	RPA1	17	1747276	Silent	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08		1747276	79447934	341	25185										
RPA1	6117	broad.mit.edu	37	chr17	1780584	1780584	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgaggggaagggaagcttttCtccctagaactggttgacga	14	8	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:1780584C>T	uc002fto.2	+	8	781	c.666C>T	c.(664-666)TTC>TTT	p.F222F		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	222					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						GGAAGCTTTTCTCCCTAGAAC	0.532								NER					0	0	0	1	0	7	22										T	1780584	C	T	1780584	2	4	83	1	0	0	0	0	0	0	0	1	13536	912	32	1		1	RPA1	17	1780584	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	33308	1780584	79414626	342	25186										
RAP1GAP2	23108	broad.mit.edu	37	chr17	2861064	2861064	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtctttcagtcgtcggagttCtttgagatgctggagaaaat	12	6	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:2861064C>G	uc010ckd.2	+	4	267	c.177C>G	c.(175-177)TTC>TTG	p.F59L	RAP1GAP2_uc010cke.2_Missense_Mutation_p.F59L	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	59					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						CGTCGGAGTTCTTTGAGATGC	0.567													0	0	0	1	0	26	57										G	2861064	C	G	2861064	3	3	83	1	0	0	0	0	1	0	0	0	13038	912	32	1	191	1	RAP1GAP2	17	2861064	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1080480	2861064	78334146	343	25187										
XAF1	54739	broad.mit.edu	37	chr17	6663026	6663026	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcatgcagaagtcctcgctgGagtttcataaggtaagagcc	12	9	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:6663026G>C	uc002gdn.2	+	3	456	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	XAF1_uc010clr.1_Missense_Mutation_p.E72Q|XAF1_uc002gdm.1_Missense_Mutation_p.E12Q|XAF1_uc002gdo.2_Intron|XAF1_uc002gdp.2_Missense_Mutation_p.W49C|XAF1_uc002gdq.2_Intron|XAF1_uc002gdr.2_Intron	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	72	TRAF-type.				apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						GTCCTCGCTGGAGTTTCATAA	0.438													0	0	0	1	0	12	48										C	6663026	G	C	6663026	3	2	83	1	0	0	0	0	1	0	0	0	17416	1175	41	1	224	1	XAF1	17	6663026	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3801962	6663026	74532184	344	25188										
ZBTB4	57659	broad.mit.edu	37	chr17	7369149	7369149	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtacattgctgtgtctcttCagactggacagggtcacgta	11	9	3	1	rs143028324		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7369149C>G	uc002ghc.3	-	3	1222	c.972G>C	c.(970-972)CTG>CTC	p.L324L	ZBTB4_uc002ghd.3_Silent_p.L324L	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	324	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		TGTGTCTCTTCAGACTGGACA	0.607													0	0	0	1	0	18	33										G	7369149	C	G	7369149	2	3	83	1	0	0	0	0	0	0	0	1	17538	813	29	1		1	ZBTB4	17	7369149	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	706123	7369149	73826061	345	25189										
TP53	7157	broad.mit.edu	37	chr17	7577511	7577511	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcctgacctggagtcttccAgtgtgatgatggtgaggatg	14	8	1	4	rs28934577		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7577511A>T	uc002gim.2	-	7	964	c.770T>A	c.(769-771)CTG>CAG	p.L257Q	TP53_uc002gig.1_Missense_Mutation_p.L257Q|TP53_uc002gih.2_Missense_Mutation_p.L257Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L125Q|TP53_uc010cng.1_Missense_Mutation_p.L125Q|TP53_uc002gii.1_Missense_Mutation_p.L125Q|TP53_uc010cnh.1_Missense_Mutation_p.L257Q|TP53_uc010cni.1_Missense_Mutation_p.L257Q|TP53_uc002gij.2_Missense_Mutation_p.L257Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.L164Q|TP53_uc002gio.2_Missense_Mutation_p.L125Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	257	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L257P(8)|p.0?(7)|p.L257Q(7)|p.L257V(4)|p.L257L(2)|p.L257fs*6(2)|p.L257fs*88(1)|p.?(1)|p.L257fs*7(1)|p.T256fs*87(1)|p.L257R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAGTCTTCCAGTGTGATGAT	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	7	26										T	7577511	A	T	7577511	3	4	83	1	0	0	0	0	1	0	0	0	16378	188	7	5	520	5	TP53	17	7577511	Missense_Mutation	SNP	A	TCGA-FD-A3SO-01A-11D-A22Z-08	208362	7577511	73617699	346	25190										
TP53	7157	broad.mit.edu	37	chr17	7579529	7579529	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacctgggtcttcagtgaacCattgttcaatatcgtccggg	11	10	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7579529C>T	uc002gim.2	-	4	352	c.158G>A	c.(157-159)TGG>TAG	p.W53*	TP53_uc002gig.1_Nonsense_Mutation_p.W53*|TP53_uc002gih.2_Nonsense_Mutation_p.W53*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W53*|TP53_uc010cni.1_Nonsense_Mutation_p.W53*|TP53_uc002gij.2_Nonsense_Mutation_p.W53*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W14*|TP53_uc010cnk.1_Nonsense_Mutation_p.W68*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	53	TADII.|Interaction with HRMT1L2.		W -> C (in sporadic cancers; somatic mutation).|W -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W53*(10)|p.0?(7)|p.W53C(2)|p.E51fs*59(1)|p.D48fs*55(1)|p.Q52fs*67(1)|p.W53fs*1(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGTGAACCATTGTTCAAT	0.592		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	49	128										T	7579529	C	T	7579529	4	4	83	1	0	0	0	0	0	1	0	0	16378	595	21	2	1144	2	TP53	17	7579529	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2018	7579529	73615681	347	25191										
MYH1	4619	broad.mit.edu	37	chr17	10419630	10419630	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tatttgggagggttcatgggGaagacttggtcatctttcac	13	6	4	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:10419630G>A	uc002gmo.2	-	4	328	c.234C>T	c.(232-234)TTC>TTT	p.F78F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	78	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGTTCATGGGGAAGACTTGGT	0.468													0	0	0	1	0	16	129										A	10419630	G	A	10419630	2	1	83	1	0	0	0	0	0	0	0	1	10029	1165	41	1		1	MYH1	17	10419630	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2840101	10419630	70775580	348	25192										
SLC46A1	113235	broad.mit.edu	37	chr17	26731743	26731743	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcggccaggcagtactgcagGagcttcagggccagcaggct	15	12	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:26731743G>C	uc002hbf.1	-	2	1068	c.972C>G	c.(970-972)CTC>CTG	p.L324L	SLC46A1_uc002hbg.1_Silent_p.L324L|SLC46A1_uc010wak.1_Silent_p.L324L	NM_080669	NP_542400	Q96NT5	PCFT_HUMAN	proton-coupled folate transporter	324	Helical; (Potential).				cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	AGTACTGCAGGAGCTTCAGGG	0.577													0	0	0	1	0	13	31										C	26731743	G	C	26731743	2	2	83	1	0	0	0	0	0	0	0	1	14644	1161	41	1		1	SLC46A1	17	26731743	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	16312113	26731743	54463467	349	25193										
SLC46A1	113235	broad.mit.edu	37	chr17	26732064	26732064	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agagtcatggctatcagcaaGgccaaggccagccagaaggg	14	10	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:26732064G>A	uc002hbf.1	-	2	747	c.651C>T	c.(649-651)GCC>GCT	p.A217A	SLC46A1_uc002hbg.1_Silent_p.A217A|SLC46A1_uc010wak.1_Silent_p.A217A	NM_080669	NP_542400	Q96NT5	PCFT_HUMAN	proton-coupled folate transporter	217	Helical; (Potential).				cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	CTATCAGCAAGGCCAAGGCCA	0.607													0	0	0	1	0	16	62										A	26732064	G	A	26732064	2	1	83	1	0	0	0	0	0	0	0	1	14644	987	35	2		2	SLC46A1	17	26732064	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	321	26732064	54463146	350	25194										
C17orf42	79736	broad.mit.edu	37	chr17	29226414	29226414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggagtcaccaatcatcagttCaaaatgcttccccactgcat	6	13	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:29226414C>T	uc002hfu.2	-	4	926	c.856G>A	c.(856-858)GAA>AAA	p.E286K	C17orf42_uc002hfv.2_RNA	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	286					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				ATCATCAGTTCAAAATGCTTC	0.468													0	0	0	1	0	34	69										T	29226414	C	T	29226414	3	4	83	1	0	0	0	0	1	0	0	0	1856	835	29	1	230	1	C17orf42	17	29226414	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2494350	29226414	51968796	351	25195										
TMEM132E	124842	broad.mit.edu	37	chr17	32959762	32959762	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acgtgtttgtgagtggaaaaGagtctcgagggtccatgaac	14	6	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:32959762G>C	uc002hif.2	+	7	1580	c.1252G>C	c.(1252-1254)GAG>CAG	p.E418Q		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	418	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GAGTGGAAAAGAGTCTCGAGG	0.567													0	0	0	1	0	18	53										C	32959762	G	C	32959762	3	2	83	1	0	0	0	0	1	0	0	0	16045	943	33	1	1278	1	TMEM132E	17	32959762	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3733348	32959762	48235448	352	25196										
NLE1	54475	broad.mit.edu	37	chr17	33463472	33463472	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcagtgctgagggccatggtGttcacccagtggccgtggcc	15	12	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:33463472G>A	uc002hiy.1	-	8	901	c.873C>T	c.(871-873)AAC>AAT	p.N291N	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	291						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				GGGCCATGGTGTTCACCCAGT	0.607													0	0	0	1	0	30	119										A	33463472	G	A	33463472	2	1	83	1	0	0	0	0	0	0	0	1	10460	1368	48	2		2	NLE1	17	33463472	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	503710	33463472	47731738	353	25197										
KRT15	3866	broad.mit.edu	37	chr17	39671846	39671846	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atctcgcatcggagctcactCagctgggcctccaggccacc	10	17	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:39671846C>T	uc002hwy.2	-	6	1316	c.1125G>A	c.(1123-1125)CTG>CTA	p.L375L	KRT15_uc002hwz.2_Silent_p.L277L|KRT15_uc002hxa.2_Silent_p.L210L|KRT15_uc002hxb.1_Silent_p.L210L	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	375	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				GGAGCTCACTCAGCTGGGCCT	0.592													0	0	0	1	0	29	56										T	39671846	C	T	39671846	2	4	83	1	0	0	0	0	0	0	0	1	8452	813	29	1		1	KRT15	17	39671846	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6208374	39671846	41523364	354	25198										
KRT15	3866	broad.mit.edu	37	chr17	39673157	39673157	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gggtcagctcatccaggactCggcgcaagccgttgatgtca	13	12	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:39673157C>T	uc002hwy.2	-	3	832	c.641G>A	c.(640-642)CGA>CAA	p.R214Q	KRT15_uc002hwz.2_Missense_Mutation_p.R116Q|KRT15_uc002hxa.2_Missense_Mutation_p.R49Q|KRT15_uc002hxb.1_Missense_Mutation_p.R49Q	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	214	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				ATCCAGGACTCGGCGCAAGCC	0.592													0	0	0	1	0	31	60										T	39673157	C	T	39673157	3	4	83	1	0	0	0	0	1	0	0	0	8452	884	31	1	753	1	KRT15	17	39673157	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1311	39673157	41522053	355	25199										
MLX	6945	broad.mit.edu	37	chr17	40723603	40723603	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	attggcgtcctgcaccaattGaaaaaccagctttactgacc	7	12	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:40723603G>A	uc002iag.2	+	8	944	c.879G>A	c.(877-879)TTG>TTA	p.L293L	MLX_uc002iaf.2_Silent_p.L239L|MLX_uc002iah.2_Silent_p.L209L	NM_170607	NP_733752	Q9UH92	MLX_HUMAN	transcription factor-like protein 4 isoform	293					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TGCACCAATTGAAAAACCAGC	0.537													0	0	0	1	0	52	122										A	40723603	G	A	40723603	2	1	83	1	0	0	0	0	0	0	0	1	9635	1281	45	1		1	MLX	17	40723603	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1050446	40723603	40471607	356	25200										
WNK4	65266	broad.mit.edu	37	chr17	40933043	40933043	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aaagaaccccccgagggcacGtggaccgagggagcccctgt	14	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:40933043G>A	uc002ibj.2	+	1	348	c.327G>A	c.(325-327)ACG>ACA	p.T109T	WNK4_uc010wgx.1_Translation_Start_Site|WNK4_uc002ibk.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	109					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCGAGGGCACGTGGACCGAGG	0.731													0	0	0	1	0	5	17										A	40933043	G	A	40933043	2	1	83	1	0	0	0	0	0	0	0	1	17377	1132	40	2		2	WNK4	17	40933043	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	209440	40933043	40262167	357	25201										
CACNA1G	8913	broad.mit.edu	37	chr17	48696036	48696036	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacaccctccgggactgtgaCcaggagtccacctgctacaa	10	15	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:48696036C>T	uc002irk.1	+	33	5820	c.5448C>T	c.(5446-5448)GAC>GAT	p.D1816D	CACNA1G_uc002irj.1_Silent_p.D1782D|CACNA1G_uc002irl.1_Silent_p.D1793D|CACNA1G_uc002irm.1_Silent_p.D1782D|CACNA1G_uc002irn.1_Silent_p.D1775D|CACNA1G_uc002iro.1_Silent_p.D1782D|CACNA1G_uc002irp.1_Silent_p.D1816D|CACNA1G_uc002irq.1_Silent_p.D1793D|CACNA1G_uc002irr.1_Silent_p.D1816D|CACNA1G_uc002irs.1_Silent_p.D1805D|CACNA1G_uc002irt.1_Silent_p.D1798D|CACNA1G_uc002irv.1_Silent_p.D1805D|CACNA1G_uc002irw.1_Silent_p.D1793D|CACNA1G_uc002iru.1_Silent_p.D1782D|CACNA1G_uc002irx.1_Silent_p.D1729D|CACNA1G_uc002iry.1_Silent_p.D1718D|CACNA1G_uc002irz.1_Silent_p.D1722D|CACNA1G_uc002isa.1_Silent_p.D1695D|CACNA1G_uc002isb.1_Silent_p.D1736D|CACNA1G_uc002isc.1_Silent_p.D1718D|CACNA1G_uc002isd.1_Silent_p.D1704D|CACNA1G_uc002ise.1_Silent_p.D1684D|CACNA1G_uc002isf.1_Silent_p.D1711D|CACNA1G_uc002isg.1_Silent_p.D1677D|CACNA1G_uc002ish.1_Silent_p.D1684D|CACNA1G_uc002isi.1_Silent_p.D1672D	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1816	IV.|Extracellular (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGACTGTGACCAGGAGTCCA	0.577													0	0	0	1	0	4	27										T	48696036	C	T	48696036	2	4	83	1	0	0	0	0	0	0	0	1	2544	506	18	2		2	CACNA1G	17	48696036	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7762993	48696036	32499174	358	25202										
OR4D1	26689	broad.mit.edu	37	chr17	56233150	56233150	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctagttatcatctggttcctCctccttctgatctcttatac	4	13	4	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:56233150C>T	uc010wno.1	+	1	636	c.636C>T	c.(634-636)CTC>CTT	p.L212L	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTGGTTCCTCCTCCTTCTGA	0.532													0	0	0	1	0	24	53										T	56233150	C	T	56233150	2	4	83	1	0	0	0	0	0	0	0	1	11053	842	30	1		1	OR4D1	17	56233150	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	7537114	56233150	24962060	359	25203										
CYB561	1534	broad.mit.edu	37	chr17	61514723	61514723	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcaccatttccctgcaggaaGatcaggcctatgaccatgca	8	13	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:61514723G>T	uc002jap.2	-	1	588	c.186C>A	c.(184-186)ATC>ATA	p.I62I	CYB561_uc002jaq.2_Silent_p.I108I|CYB561_uc002jar.2_Silent_p.I62I|CYB561_uc002jas.2_Silent_p.I62I|CYB561_uc010ddt.2_Silent_p.I62I|CYB561_uc002jat.2_Silent_p.I62I|CYB561_uc010wpf.1_Silent_p.I62I|CYB561_uc010wpg.1_Silent_p.I33I	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	62	Helical; (Potential).|Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		CCTGCAGGAAGATCAGGCCTA	0.647													1	0	6.31663e-08	1	6.54403e-08	16	47										T	61514723	G	T	61514723	2	4	83	1	0	0	0	0	0	0	0	1	4119	932	33	3		3	CYB561	17	61514723	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	5281573	61514723	19680487	360	25204										
LRRC37A3	374819	broad.mit.edu	37	chr17	62864606	62864606	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tccagttcaacagtcatcatGagaatgttcttaagtgttgt	8	7	4	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:62864606G>A	uc002jey.2	-	9	3558	c.3027C>T	c.(3025-3027)CTC>CTT	p.L1009L	LRRC37A3_uc010wqg.1_Silent_p.L127L|LRRC37A3_uc010wqf.1_Silent_p.L47L|LRRC37A3_uc010dek.1_Silent_p.L15L	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1009	Extracellular (Potential).|LRR 9.					integral to membrane					0						CAGTCATCATGAGAATGTTCT	0.313													0	0	0	1	0	40	105										A	62864606	G	A	62864606	2	1	83	1	0	0	0	0	0	0	0	1	8993	1277	45	1		1	LRRC37A3	17	62864606	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1349883	62864606	18330604	361	25205										
LRRC37A3	374819	broad.mit.edu	37	chr17	62865241	62865241	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taatgctggcaatttaaagaGatatggatcttcaacagttg	9	5	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:62865241G>C	uc002jey.2	-	8	3481	c.2950C>G	c.(2950-2952)CTC>GTC	p.L984V	LRRC37A3_uc010wqg.1_Missense_Mutation_p.L102V|LRRC37A3_uc010wqf.1_Missense_Mutation_p.L22V|LRRC37A3_uc010dek.1_Translation_Start_Site	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	984	Extracellular (Potential).|LRR 8.					integral to membrane					0						AATTTAAAGAGATATGGATCT	0.299													0	0	0	1	0	40	126										C	62865241	G	C	62865241	3	2	83	1	0	0	0	0	1	0	0	0	8993	942	33	1	1982	1	LRRC37A3	17	62865241	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	635	62865241	18329969	362	25206										
ABCA10	10349	broad.mit.edu	37	chr17	67145021	67145021	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aactgttgtatcaattttatCatcaacatttcccagctcct	3	11	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:67145021C>T	uc010dfa.1	-	40	5458	c.4579G>A	c.(4579-4581)GAT>AAT	p.D1527N	ABCA10_uc002jhz.2_RNA|ABCA10_uc010wqs.1_Missense_Mutation_p.D519N|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1527					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TCAATTTTATCATCAACATTT	0.348													0	0	0	1	0	18	71										T	67145021	C	T	67145021	3	4	83	1	0	0	0	0	1	0	0	0	29	826	29	1	56	1	ABCA10	17	67145021	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4279780	67145021	14050189	363	25207										
MRPL38	64978	broad.mit.edu	37	chr17	73895341	73895341	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttggtgtttcttgtagaaatCaaaagtgcggaaggtccgct	12	6	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:73895341C>G	uc010wso.1	-	8	1129	c.904G>C	c.(904-906)GAT>CAT	p.D302H	FBF1_uc002jqa.1_RNA|TRIM65_uc002jpx.2_5'Flank|MRPL38_uc002jpz.1_RNA	NM_032478	NP_115867	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38 precursor	302						actin cytoskeleton|mitochondrion|ribosome				pancreas(1)	1			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGTAGAAATCAAAAGTGCGG	0.557													0	0	0	1	0	5	14										G	73895341	C	G	73895341	3	3	83	1	0	0	0	0	1	0	0	0	9801	826	29	1	246	1	MRPL38	17	73895341	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6750320	73895341	7299869	364	25208										
RNF213	57674	broad.mit.edu	37	chr17	78314035	78314035	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtcaccccccaggcacccctCgaggccatccaagcctacct	7	21	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:78314035C>T	uc002jyh.1	+	1	310	c.87C>T	c.(85-87)CTC>CTT	p.L29L		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGGCACCCCTCGAGGCCATCC	0.632													0	0	0	1	0	11	33										T	78314035	C	T	78314035	2	4	83	1	0	0	0	0	0	0	0	1	13477	871	31	1		1	RNF213	17	78314035	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4418694	78314035	2881175	365	25209										
HGS	9146	broad.mit.edu	37	chr17	79667810	79667810	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gggctacatggggagccagtCagtctccatgggctaccagc	14	12	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:79667810C>T	uc002kbg.2	+	20	2179	c.2102C>T	c.(2101-2103)TCA>TTA	p.S701L	MRPL12_uc002kbh.1_5'Flank|SLC25A10_uc010wut.1_5'Flank	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	701	Interaction with NF2.|Gln-rich.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GGGAGCCAGTCAGTCTCCATG	0.637													0	0	0	1	0	13	35										T	79667810	C	T	79667810	3	4	83	1	0	0	0	0	1	0	0	0	7087	838	29	1	2180	1	HGS	17	79667810	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1353775	79667810	1527400	366	25210										
CSNK1D	1453	broad.mit.edu	37	chr17	80223668	80223668	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcttctcctgcagcaatgtcCgtaccttggcaaagaaagaa	8	11	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80223668C>T	uc002kej.2	-	2	397	c.81G>A	c.(79-81)ACG>ACA	p.T27T	CSNK1D_uc002kef.2_Silent_p.T27T|CSNK1D_uc002kei.2_Silent_p.T27T|CSNK1D_uc010wvj.1_5'UTR	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	27	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CAGCAATGTCCGTACCTTGGC	0.438													0	0	0	1	0	37	76										T	80223668	C	T	80223668	2	4	83	1	0	0	0	0	0	0	0	1	3952	639	23	2		2	CSNK1D	17	80223668	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	555858	80223668	971542	367	25211										
C17orf101	79701	broad.mit.edu	37	chr17	80373478	80373478	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctgccacagcctctgcacctCccgcggggctcggtccttct	10	19	2	0	rs116051835	by1000genomes	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80373478C>T	uc002keu.1	-	2	201	c.100G>A	c.(100-102)GAG>AAG	p.E34K	C17orf101_uc002ket.1_Missense_Mutation_p.E34K|C17orf101_uc010dip.1_RNA|HEXDC_uc002kev.3_5'Flank|HEXDC_uc010diq.2_5'Flank	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	34	Cytoplasmic (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						CTCTGCACCTCCCGCGGGGCT	0.637													0	0	0	1	0	14	23										T	80373478	C	T	80373478	3	4	83	1	0	0	0	0	1	0	0	0	1848	864	30	1	1068	1	C17orf101	17	80373478	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	149810	80373478	821732	368	25212										
FOXK2	3607	broad.mit.edu	37	chr17	80477922	80477922	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtatctgatgaagaagcgctCggtgaccatcggccgcaact	12	11	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80477922C>T	uc002kfn.2	+	1	329	c.158C>T	c.(157-159)TCG>TTG	p.S53L	FOXK2_uc002kfm.1_Missense_Mutation_p.S53L|FOXK2_uc010diu.2_Missense_Mutation_p.S53L	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	53	Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			AAGAAGCGCTCGGTGACCATC	0.557													0	0	0	1	0	13	22										T	80477922	C	T	80477922	3	4	83	1	0	0	0	0	1	0	0	0	6015	893	31	1	160	1	FOXK2	17	80477922	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	104444	80477922	717288	369	25213										
CLUL1	27098	broad.mit.edu	37	chr18	627295	627295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcttcagacagatgcagcaaGagtttgaccagacttttcaa	8	9	3	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:627295G>C	uc002kkp.2	+	5	767	c.622G>C	c.(622-624)GAG>CAG	p.E208Q	CLUL1_uc010wys.1_Missense_Mutation_p.E260Q|CLUL1_uc002kkq.2_Missense_Mutation_p.E208Q	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	208					cell death	extracellular region				ovary(2)	2						GATGCAGCAAGAGTTTGACCA	0.408													0	0	0	1	0	52	147										C	627295	G	C	627295	3	2	83	1	0	0	0	0	1	0	0	0	3570	943	33	1	636	1	CLUL1	18	627295	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		627295	77449953	370	25214										
LAMA1	284217	broad.mit.edu	37	chr18	6966276	6966276	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cactcccgtcaaaatggaagGaagggtcttcattctgggag	12	9	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:6966276G>A	uc002knm.2	-	49	7014	c.6920C>T	c.(6919-6921)TCC>TTC	p.S2307F	LAMA1_uc002knl.2_5'Flank|LAMA1_uc010wzj.1_Missense_Mutation_p.S1783F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2307	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAATGGAAGGAAGGGTCTTC	0.448													0	0	0	1	0	9	20										A	6966276	G	A	6966276	3	1	83	1	0	0	0	0	1	0	0	0	8605	1174	41	1	2367	1	LAMA1	18	6966276	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6338981	6966276	71110972	371	25215										
KIAA0802	23255	broad.mit.edu	37	chr18	8825631	8825631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gacaggtggcccctgccatcGagaaggtgcaggccaagttt	14	11	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:8825631G>A	uc002knr.2	+	15	4265	c.4123G>A	c.(4123-4125)GAG>AAG	p.E1375K	KIAA0802_uc002knq.2_Missense_Mutation_p.E1334K|KIAA0802_uc002kns.2_Missense_Mutation_p.E715K	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1685											0						CCCTGCCATCGAGAAGGTGCA	0.607													0	0	0	1	0	10	22										A	8825631	G	A	8825631	3	1	83	1	0	0	0	0	1	0	0	0	8194	1059	37	1	4173	1	KIAA0802	18	8825631	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1859355	8825631	69251617	372	25216										
TAF4B	6875	broad.mit.edu	37	chr18	23915183	23915183	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaacagctgagattaaagcaGaaagccaaagaggtaggact	12	6	0	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:23915183G>A	uc002kvu.3	+	13	2793	c.2304G>A	c.(2302-2304)CAG>CAA	p.Q768Q	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Silent_p.Q773Q	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	768	Potential.				transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			GATTAAAGCAGAAAGCCAAAG	0.383													0	0	0	1	0	8	23										A	23915183	G	A	23915183	2	1	83	1	0	0	0	0	0	0	0	1	15524	933	33	1		1	TAF4B	18	23915183	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	15089552	23915183	54162065	373	25217										
KLHL14	57565	broad.mit.edu	37	chr18	30350474	30350474	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcgcaaaacagctgcttcctCcacagcaggttgaggccgtg	11	13	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:30350474C>A	uc002kxm.1	-	2	469	c.81G>T	c.(79-81)TGG>TGT	p.W27C		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	27						cytosol|endoplasmic reticulum membrane				ovary(1)	1						GCTGCTTCCTCCACAGCAGGT	0.642													1	0	2.70639e-06	1	2.76511e-06	21	22										A	30350474	C	A	30350474	3	1	83	1	0	0	0	0	1	0	0	0	8370	856	30	3	1837	3	KLHL14	18	30350474	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6435291	30350474	47726774	374	25218										
ATP8B1	5205	broad.mit.edu	37	chr18	55368464	55368464	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caccacatcgtccaccaggtCtttgattgcagtgacgccca	8	15	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:55368464C>T	uc002lgw.2	-	4	475	c.475G>A	c.(475-477)GAC>AAC	p.D159N	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	159	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				TCCACCAGGTCTTTGATTGCA	0.463									Byler_disease				0	0	0	1	0	14	27										T	55368464	C	T	55368464	3	4	83	1	0	0	0	0	1	0	0	0	1194	913	32	1	3376	1	ATP8B1	18	55368464	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	25017990	55368464	22708784	375	25219										
PCSK4	54760	broad.mit.edu	37	chr19	1487786	1487786	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tgtgggagccctgctcaccgGttctctttgctgggggtgta	15	10	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1487786G>A	uc002ltb.1	-	5	653	c.591C>T	c.(589-591)AAC>AAT	p.N197N	PCSK4_uc002lta.2_Missense_Mutation_p.T39I	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	197	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCACCGGTTCTCTTTGC	0.682													0	0	0	1	0	6	3										A	1487786	G	A	1487786	2	1	83	1	0	0	0	0	0	0	0	1	11602	1252	44	2		2	PCSK4	19	1487786	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		1487786	57641197	376	25220										
ADAMTSL5	339366	broad.mit.edu	37	chr19	1508069	1508069	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcagcggccacagcggtcctCgagggcacccgagcccaaca	13	17	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1508069C>T	uc002ltd.2	-	7	973	c.529G>A	c.(529-531)GAG>AAG	p.E177K	ADAMTSL5_uc010dsl.2_5'UTR|ADAMTSL5_uc010xgq.1_Missense_Mutation_p.E187K	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	177						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCGGTCCTCGAGGGCACCC	0.682													0	0	0	1	0	6	11										T	1508069	C	T	1508069	3	4	83	1	0	0	0	0	1	0	0	0	278	893	31	1	910	1	ADAMTSL5	19	1508069	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	20283	1508069	57620914	377	25221										
ATP8B3	148229	broad.mit.edu	37	chr19	1785612	1785612	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaggtggtcacaccatgggcGatggcttggacgaagaccca	15	10	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1785612G>A	uc002ltw.2	-	26	3483	c.3249C>T	c.(3247-3249)ATC>ATT	p.I1083I	ATP8B3_uc002ltv.2_Silent_p.I1046I|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1083	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCATGGGCGATGGCTTGGA	0.607													0	0	0	1	0	6	10										A	1785612	G	A	1785612	2	1	83	1	0	0	0	0	0	0	0	1	1196	1048	37	1		1	ATP8B3	19	1785612	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	277543	1785612	57343371	378	25222										
C3	718	broad.mit.edu	37	chr19	6678241	6678241	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cctccagcttcagggcttctCtgcacttgatggggctgatg	12	12	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:6678241C>T	uc002mfm.2	-	40	4834	c.4772G>A	c.(4771-4773)AGA>AAA	p.R1591K	C3_uc002mfl.2_Missense_Mutation_p.R327K	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1591	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAGGGCTTCTCTGCACTTGAT	0.587													0	0	0	1	0	16	31										T	6678241	C	T	6678241	3	4	83	1	0	0	0	0	1	0	0	0	2204	913	32	1	227	1	C3	19	6678241	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4892629	6678241	52450742	379	25223										
MUC16	94025	broad.mit.edu	37	chr19	9057637	9057637	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agagagcctggtgatcacttCagtgatgatgtctggagaca	13	7	3	5			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:9057637C>T	uc002mkp.2	-	3	30013	c.29809G>A	c.(29809-29811)GAA>AAA	p.E9937K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9939	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGATCACTTCAGTGATGATG	0.453													0	0	0	1	0	64	115										T	9057637	C	T	9057637	3	4	83	1	0	0	0	0	1	0	0	0	9973	835	29	1	14042	1	MUC16	19	9057637	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2379396	9057637	50071346	380	25224										
EPOR	2057	broad.mit.edu	37	chr19	11489167	11489167	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggctccactgcctgcatcgtCccccagcagcgctctgagag	11	17	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:11489167C>T	uc002mrj.1	-	8	1156	c.1020G>A	c.(1018-1020)GGG>GGA	p.G340G	EPOR_uc002mrh.2_5'UTR|EPOR_uc002mri.2_Silent_p.G167G|EPOR_uc002mrk.1_Silent_p.G167G|EPOR_uc002mrl.1_RNA|EPOR_uc010xlx.1_RNA|EPOR_uc010xly.1_Silent_p.G167G	NM_000121	NP_000112	P19235	EPOR_HUMAN	erythropoietin receptor precursor	340	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CCTGCATCGTCCCCCAGCAGC	0.632													0	0	0	1	0	17	21										T	11489167	C	T	11489167	2	4	83	1	0	0	0	0	0	0	0	1	5189	842	30	1		1	EPOR	19	11489167	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2431530	11489167	47639816	381	25225										
ZNF441	126068	broad.mit.edu	37	chr19	11890924	11890924	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caagacagtattgtgaacgaGaaaatacctggagtagatcc	10	7	0	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:11890924G>A	uc010dyj.2	+	4	479	c.285G>A	c.(283-285)GAG>GAA	p.E95E	ZNF441_uc002msn.3_Silent_p.E51E	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTGTGAACGAGAAAATACCTG	0.413													0	0	0	1	0	21	53										A	11890924	G	A	11890924	2	1	83	1	0	0	0	0	0	0	0	1	17911	933	33	1		1	ZNF441	19	11890924	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	401757	11890924	47238059	382	25226										
KLF1	10661	broad.mit.edu	37	chr19	12997900	12997900	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atcctgtgtgtccgggaaggGgcccagggcggtcagtgtgc	18	10	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:12997900G>A	uc002mvo.2	-	1	118	c.55C>T	c.(55-57)CCC>TCC	p.P19S		NM_006563	NP_006554	Q13351	KLF1_HUMAN	erythroid Kruppel-like factor	19	Pro-rich.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGGAAGGGGCCCAGGGCG	0.657													0	0	0	1	0	23	38										A	12997900	G	A	12997900	3	1	83	1	0	0	0	0	1	0	0	0	8337	1232	43	2	1045	2	KLF1	19	12997900	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1106976	12997900	46131083	383	25227										
AKAP8L	26993	broad.mit.edu	37	chr19	15512157	15512157	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cagacatgcactggccccggGcccccatggggtcttcccac	11	18	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:15512157G>A	uc002naw.1	-	5	719	c.620C>T	c.(619-621)GCC>GTC	p.A207V	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.A146V|AKAP8L_uc002nay.1_Missense_Mutation_p.A207V|AKAP8L_uc002naz.2_Missense_Mutation_p.A55V	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	207						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CTGGCCCCGGGCCCCCATGGG	0.692													0	0	0	1	0	13	54										A	15512157	G	A	15512157	3	1	83	1	0	0	0	0	1	0	0	0	458	1203	42	2	1360	2	AKAP8L	19	15512157	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2514257	15512157	43616826	384	25228										
FCHO1	23149	broad.mit.edu	37	chr19	17889421	17889421	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccgcttccctccccaaggctCtagcagcctgggcttcacct	8	19	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:17889421C>T	uc010ebb.2	+	19	1544	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	FCHO1_uc002nhg.3_Missense_Mutation_p.S452F|FCHO1_uc002nhh.2_Missense_Mutation_p.S452F|FCHO1_uc010xpw.1_Missense_Mutation_p.S402F|FCHO1_uc002nhi.2_5'UTR|FCHO1_uc002nhj.2_5'UTR	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	452										breast(1)	1						CCCCAAGGCTCTAGCAGCCTG	0.682													0	0	0	1	0	3	2										T	17889421	C	T	17889421	3	4	83	1	0	0	0	0	1	0	0	0	5787	913	32	1	1421	1	FCHO1	19	17889421	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2377264	17889421	41239562	385	25229										
IL12RB1	3594	broad.mit.edu	37	chr19	18174783	18174783	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acaccagcccgcaggccactGagggtaacttgggtctctgt	12	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:18174783G>A	uc002nhw.1	-	13	1585	c.1521C>T	c.(1519-1521)CTC>CTT	p.L507L	IL12RB1_uc010xqb.1_Silent_p.L507L|IL12RB1_uc002nhx.1_Silent_p.L547L	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	507	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCAGGCCACTGAGGGTAACTT	0.647													0	0	0	1	0	9	19										A	18174783	G	A	18174783	2	1	83	1	0	0	0	0	0	0	0	1	7626	1277	45	1		1	IL12RB1	19	18174783	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	285362	18174783	40954200	386	25230										
ZNF93	81931	broad.mit.edu	37	chr19	20044424	20044424	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tctgcccttaatacacataaGagaattcatactggagagaa	7	8	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:20044424G>C	uc002non.2	+	4	771	c.660G>C	c.(658-660)AAG>AAC	p.K220N		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	220	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						ATACACATAAGAGAATTCATA	0.368													0	0	0	1	0	11	31										C	20044424	G	C	20044424	3	2	83	1	0	0	0	0	1	0	0	0	18199	933	33	1	674	1	ZNF93	19	20044424	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	1869641	20044424	39084559	387	25231										
ZNF257	113835	broad.mit.edu	37	chr19	22271978	22271978	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accagtcttcacaccttactCaacataaaataattcatact	1	12	4	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:22271978C>G	uc010ecx.2	+	4	1595	c.1426C>G	c.(1426-1428)CAA>GAA	p.Q476E	ZNF257_uc010ecy.2_Missense_Mutation_p.Q444E	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	476	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACACCTTACTCAACATAAAAT	0.383													0	0	0	1	0	16	31										G	22271978	C	G	22271978	3	3	83	1	0	0	0	0	1	0	0	0	17797	827	29	1	1440	1	ZNF257	19	22271978	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2227554	22271978	36857005	388	25232										
ETV2	2116	broad.mit.edu	37	chr19	36135582	36135582	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gctgtggggcgagcgcaagaGaaagccgggcatgaattacg	17	8	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:36135582G>C	uc002oas.2	+	6	1380	c.941G>C	c.(940-942)AGA>ACA	p.R314T	ETV2_uc002oar.2_Missense_Mutation_p.R286T|ETV2_uc002oat.2_Missense_Mutation_p.R193T|ETV2_uc002oau.2_Missense_Mutation_p.R99T	NM_014209	NP_055024	O00321	ETV2_HUMAN	ets variant gene 2	285							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCGCAAGAGAAAGCCGGGC	0.672													0	0	0	1	0	4	18										C	36135582	G	C	36135582	3	2	83	1	0	0	0	0	1	0	0	0	5278	942	33	1	879	1	ETV2	19	36135582	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	13863604	36135582	22993401	389	25233										
ZBTB32	27033	broad.mit.edu	37	chr19	36206116	36206116	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggtcaaaggagaaacgcctCcaagcccctgttggccaaag	11	12	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:36206116C>T	uc002oay.2	+	2	798	c.588C>T	c.(586-588)CTC>CTT	p.L196L	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	196					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGAAACGCCTCCAAGCCCCTG	0.587													0	0	0	1	0	18	40										T	36206116	C	T	36206116	2	4	83	1	0	0	0	0	0	0	0	1	17532	842	30	1		1	ZBTB32	19	36206116	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	70534	36206116	22922867	390	25234										
PSG3	5671	broad.mit.edu	37	chr19	43236942	43236942	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	caggagatactcacggaggaGattcagggtgactgggtcac	15	8	3	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:43236942G>C	uc002oue.2	-	3	835	c.703C>G	c.(703-705)CTC>GTC	p.L235V	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Missense_Mutation_p.L257V	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	235					defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TCACGGAGGAGATTCAGGGTG	0.537													0	0	0	1	0	98	270										C	43236942	G	C	43236942	3	2	83	1	0	0	0	0	1	0	0	0	12656	942	33	1	599	1	PSG3	19	43236942	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	7030826	43236942	15892041	391	25235										
DHDH	27294	broad.mit.edu	37	chr19	49445720	49445720	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tggatgacactgtcacggtgCtcctgcagtacccaggggag	14	11	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:49445720C>T	uc002ple.1	+	5	683	c.643C>T	c.(643-645)CTC>TTC	p.L215F		NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase	215					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		TGTCACGGTGCTCCTGCAGTA	0.428													0	0	0	1	0	6	21										T	49445720	C	T	49445720	3	4	83	1	0	0	0	0	1	0	0	0	4479	797	28	2	661	2	DHDH	19	49445720	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6208778	49445720	9683263	392	25236										
ZNF613	79898	broad.mit.edu	37	chr19	52448420	52448420	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cacactggagagaaaccctaTgtatgcaatgaatgtgggaa	11	7	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:52448420T>C	uc002pxz.1	+	6	1707	c.1284T>C	c.(1282-1284)TAT>TAC	p.Y428Y	ZNF613_uc002pya.1_Silent_p.Y392Y	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	428	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		AGAAACCCTATGTATGCAATG	0.423													0	0	0	1	0	30	32										C	52448420	T	C	52448420	2	2	83	1	0	0	0	0	0	0	0	1	18035	1471	51	5		5	ZNF613	19	52448420	Silent	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	3002700	52448420	6680563	393	25237										
VSTM1	284415	broad.mit.edu	37	chr19	54545036	54545036	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	taagcgggaggactcaccgaGagagataccctttccatatt	10	10	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:54545036G>A	uc002qcw.3	-	8	764	c.588C>T	c.(586-588)CTC>CTT	p.L196L	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Silent_p.L165L	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	196						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GACTCACCGAGAGAGATACCC	0.463													0	0	0	1	0	7	10										A	54545036	G	A	54545036	2	1	83	1	0	0	0	0	0	0	0	1	17225	929	33	1		1	VSTM1	19	54545036	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2096616	54545036	4583947	394	25238										
CNOT3	4849	broad.mit.edu	37	chr19	54649696	54649696	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gccacagccacatggaggatGagatcttcaaccagtccagc	10	13	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:54649696G>A	uc002qdj.1	+	9	1065	c.754G>A	c.(754-756)GAG>AAG	p.E252K	CNOT3_uc010yel.1_Missense_Mutation_p.E252K|CNOT3_uc002qdi.2_Missense_Mutation_p.E165K|CNOT3_uc002qdk.1_Missense_Mutation_p.E252K|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	252					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CATGGAGGATGAGATCTTCAA	0.642													0	0	0	1	0	15	25										A	54649696	G	A	54649696	3	1	83	1	0	0	0	0	1	0	0	0	3620	1291	45	1	784	1	CNOT3	19	54649696	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	104660	54649696	4479287	395	25239										
ZNF548	147694	broad.mit.edu	37	chr19	57911010	57911010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agaaaggccttacgagtgcaGagagtgtgggaaagccttta	14	6	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:57911010G>A	uc002qom.2	+	3	1605	c.1355G>A	c.(1354-1356)AGA>AAA	p.R452K	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.R455K	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	452	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACGAGTGCAGAGAGTGTGGG	0.468													0	0	0	1	0	18	32										A	57911010	G	A	57911010	3	1	83	1	0	0	0	0	1	0	0	0	17977	942	33	1	1405	1	ZNF548	19	57911010	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	3261314	57911010	1217973	396	25240										
SLC27A5	10998	broad.mit.edu	37	chr19	59012064	59012064	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gcggactgtatgtgtccggtCctctggttgctacaggaatg	14	9	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:59012064C>T	uc002qtc.2	-	5	1302	c.1192G>A	c.(1192-1194)GAC>AAC	p.D398N	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	398	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TGTGTCCGGTCCTCTGGTTGC	0.572													0	0	0	1	0	17	22										T	59012064	C	T	59012064	3	4	83	1	0	0	0	0	1	0	0	0	14529	855	30	1	904	1	SLC27A5	19	59012064	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1101054	59012064	116919	397	25241										
CHGB	1114	broad.mit.edu	37	chr20	5903125	5903125	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agccccaggggaggaggacaTccaaggcccaacaaaggcag	14	12	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:5903125T>C	uc002wmg.2	+	4	641	c.335T>C	c.(334-336)ATC>ACC	p.I112T	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	112						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAGGAGGACATCCAAGGCCCA	0.602													0	0	0	1	0	12	28										C	5903125	T	C	5903125	3	2	83	1	0	0	0	0	1	0	0	0	3339	1435	50	5	349	5	CHGB	20	5903125	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08		5903125	57122395	398	25242										
SNRPB2	6629	broad.mit.edu	37	chr20	16719545	16719545	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaaattcaacaccaaatcctCaggtaattttttttccatgt	4	9	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:16719545C>A	uc002wph.1	+	5	643	c.427C>A	c.(427-429)CAG>AAG	p.Q143K	SNRPB2_uc002wpi.1_Missense_Mutation_p.Q143K	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	143						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						ACCAAATCCTCAGGTAATTTT	0.328													1	0	2.0095e-06	1	2.05715e-06	6	16										A	16719545	C	A	16719545	3	1	83	1	0	0	0	0	1	0	0	0	14862	827	29	3	441	3	SNRPB2	20	16719545	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10816420	16719545	46305975	399	25243										
RALGAPA2	57186	broad.mit.edu	37	chr20	20563711	20563711	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tacctgttaaatttgaagcaTcggtgggactcagttgtaac	10	7	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:20563711T>A	uc002wrz.2	-	20	2833	c.2690A>T	c.(2689-2691)GAT>GTT	p.D897V	RALGAPA2_uc010gcx.2_Missense_Mutation_p.D601V|RALGAPA2_uc010zsg.1_Missense_Mutation_p.D345V	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	897					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						ATTTGAAGCATCGGTGGGACT	0.463													0	0	0	1	0	16	26										A	20563711	T	A	20563711	3	1	83	1	0	0	0	0	1	0	0	0	13014	1435	50	5	3011	5	RALGAPA2	20	20563711	Missense_Mutation	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	3844166	20563711	42461809	400	25244										
ASXL1	171023	broad.mit.edu	37	chr20	31024321	31024321	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cccaggagatcttactacctCgagaacacctcgtttctcat	6	14	2	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:31024321C>T	uc002wxs.2	+	12	4232	c.3806C>T	c.(3805-3807)TCG>TTG	p.S1269L	ASXL1_uc010geb.2_Missense_Mutation_p.S1160L	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1269					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.L1266fs*9(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTTACTACCTCGAGAACACCT	0.493			F|N|Mis		MDS|CMML								0	0	0	1	0	19	60										T	31024321	C	T	31024321	3	4	83	1	0	0	0	0	1	0	0	0	1066	893	31	1	3862	1	ASXL1	20	31024321	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	10460610	31024321	32001199	401	25245										
NDRG3	57446	broad.mit.edu	37	chr20	35310978	35310978	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ccaattccaatgatgcttttCaggctgtgaatgggacataa	9	8	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:35310978C>T	uc002xfw.2	-	7	469	c.387G>A	c.(385-387)CTG>CTA	p.L129L	NDRG3_uc002xfx.2_Silent_p.L117L|NDRG3_uc010zvq.1_Silent_p.L34L|NDRG3_uc010zvr.1_Silent_p.L17L	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	129					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				TGATGCTTTTCAGGCTGTGAA	0.373													0	0	0	1	0	39	48										T	35310978	C	T	35310978	2	4	83	1	0	0	0	0	0	0	0	1	10253	813	29	1		1	NDRG3	20	35310978	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	4286657	35310978	27714542	402	25246										
PPP1R16B	26051	broad.mit.edu	37	chr20	37524349	37524349	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acctggtgaagatcctcgttCagtagtacgtgcccctccct	9	14	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:37524349C>T	uc002xje.2	+	4	652	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	PPP1R16B_uc010ggc.2_Nonsense_Mutation_p.Q155*	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	155	ANK 2.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GATCCTCGTTCAGTAGTACGT	0.468													0	0	0	1	0	9	18										T	37524349	C	T	37524349	4	4	83	1	0	0	0	0	0	1	0	0	12366	827	29	1	473	1	PPP1R16B	20	37524349	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2213371	37524349	25501171	403	25247										
SEMG2	6407	broad.mit.edu	37	chr20	43850441	43850441	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggacaaaaagaccaacaacaTactaaatccaaaggcagttt	6	9	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:43850441T>C	uc010ggz.2	+	2	225	c.168T>C	c.(166-168)CAT>CAC	p.H56H	SEMG2_uc002xnk.2_Silent_p.H56H|SEMG2_uc002xnl.2_Silent_p.H56H	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	56					sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				ACCAACAACATACTAAATCCA	0.403													0	0	0	1	0	25	82										C	43850441	T	C	43850441	2	2	83	1	0	0	0	0	0	0	0	1	14045	1403	49	5		5	SEMG2	20	43850441	Silent	SNP	T	TCGA-FD-A3SO-01A-11D-A22Z-08	6326092	43850441	19175079	404	25248										
NFATC2	4773	broad.mit.edu	37	chr20	50140650	50140650	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cttatgtgcattcggctcttCtggaaagagaagggggaagg	15	6	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:50140650C>T	uc002xwd.2	-	2	351	c.131_splice	c.e2-1	p.E44_splice	NFATC2_uc002xwc.2_Splice_Site_p.E44_splice|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Splice_Site_p.E24_splice|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Splice_Site_p.E24_splice	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,						B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					TTCGGCTCTTCTGGAAAGAGA	0.537													0	0	0	1	0	13	32										T	50140650	C	T	50140650	5	4	83	1	0	0	0	0	0	0	1	0	10362	927	32	1	2731	1	NFATC2	20	50140650	Splice_Site	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6290209	50140650	12884870	405	25249										
SPO11	23626	broad.mit.edu	37	chr20	55909876	55909876	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	agatggcaccaaagtgaattGtacctgtggtgcaacggtaa	12	7	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:55909876G>C	uc002xye.2	+	6	674	c.581G>C	c.(580-582)TGT>TCT	p.C194S	SPO11_uc002xyf.2_Missense_Mutation_p.C156S	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	194					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			AAAGTGAATTGTACCTGTGGT	0.343								Editing_and_processing_nucleases					0	0	0	1	0	10	33										C	55909876	G	C	55909876	3	2	83	1	0	0	0	0	1	0	0	0	15076	1377	48	4	603	4	SPO11	20	55909876	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	5769226	55909876	7115644	406	25250										
SYCP2	10388	broad.mit.edu	37	chr20	58467098	58467098	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ctcagaagtcaattctttctCtgcttttctatgactttgca	5	10	5	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:58467098C>T	uc002yaz.2	-	23	2450	c.2311G>A	c.(2311-2313)GAG>AAG	p.E771K		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	771					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AATTCTTTCTCTGCTTTTCTA	0.333													0	0	0	1	0	15	35										T	58467098	C	T	58467098	3	4	83	1	0	0	0	0	1	0	0	0	15429	922	32	1	2369	1	SYCP2	20	58467098	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2557222	58467098	4558422	407	25251										
ADRM1	11047	broad.mit.edu	37	chr20	60878723	60878723	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgggcgggaaagatgtccctGaaggggaccaccgtgactcc	15	12	0	3	rs144780505		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:60878723G>A	uc002ycn.2	+	2	179	c.99G>A	c.(97-99)CTG>CTA	p.L33L	ADRM1_uc011aai.1_Silent_p.L33L|ADRM1_uc002yco.2_Silent_p.L33L|ADRM1_uc002ycp.1_5'Flank	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	33	PH.|Interaction with PSMD1.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			AGATGTCCCTGAAGGGGACCA	0.597													0	0	0	1	0	40	82										A	60878723	G	A	60878723	2	1	83	1	0	0	0	0	0	0	0	1	345	1277	45	1		1	ADRM1	20	60878723	Silent	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2411625	60878723	2146797	408	25252										
DIDO1	11083	broad.mit.edu	37	chr20	61513083	61513083	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttcaggagccctttccacctCgtggcgccgccctcgctcca	9	19	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:61513083C>T	uc002ydr.1	-	16	4489	c.4225G>A	c.(4225-4227)GAG>AAG	p.E1409K	DIDO1_uc002yds.1_Missense_Mutation_p.E1409K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1409					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTTCCACCTCGTGGCGCCGC	0.602													0	0	0	1	0	44	72										T	61513083	C	T	61513083	3	4	83	1	0	0	0	0	1	0	0	0	4522	893	31	1	2501	1	DIDO1	20	61513083	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	634360	61513083	1512437	409	25253										
CHRNA4	1137	broad.mit.edu	37	chr20	61991019	61991019	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttcttcaggagccgctcctCggcgtgggcccgggtctcca	13	15	3	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:61991019C>T	uc002yes.2	-	2	287	c.109G>A	c.(109-111)GAG>AAG	p.E37K	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	37	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AGCCGCTCCTCGGCGTGGGCC	0.667													0	0	0	1	0	11	28										T	61991019	C	T	61991019	3	4	83	1	0	0	0	0	1	0	0	0	3385	893	31	1	1794	1	CHRNA4	20	61991019	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	477936	61991019	1034501	410	25254										
STMN3	50861	broad.mit.edu	37	chr20	62273466	62273466	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gccccgcccccgcaccttctCgcgcagccgctcgcgcagtg	11	22	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:62273466C>G	uc002yfr.1	-	4	560	c.478G>C	c.(478-480)GAG>CAG	p.E160Q	STMN3_uc011abb.1_Missense_Mutation_p.E160Q	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	160	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			CGCACCTTCTCGCGCAGCCGC	0.368													0	0	0	1	0	3	15										G	62273466	C	G	62273466	3	3	83	1	0	0	0	0	1	0	0	0	15309	893	31	1	72	1	STMN3	20	62273466	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	282447	62273466	752054	411	25255										
STMN3	50861	broad.mit.edu	37	chr20	62275132	62275132	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cctccgctcctcggctgcctCcagccgcttttgcagctcct	8	20	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:62275132C>G	uc002yfr.1	-	3	350	c.268G>C	c.(268-270)GAG>CAG	p.E90Q	STMN3_uc011abb.1_Missense_Mutation_p.E90Q	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	90	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			TCGGCTGCCTCCAGCCGCTTT	0.642													0	0	0	1	0	13	36										G	62275132	C	G	62275132	3	3	83	1	0	0	0	0	1	0	0	0	15309	864	30	1	286	1	STMN3	20	62275132	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	1666	62275132	750388	412	25256										
ADAMTS5	11096	broad.mit.edu	37	chr21	28302318	28302318	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgccgtcacagccagttctCacacacttcccccggacgca	7	18	2	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr21:28302318C>T	uc002ymg.2	-	7	2841	c.2112G>A	c.(2110-2112)GTG>GTA	p.V704V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	704	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AGCCAGTTCTCACACACTTCC	0.493													0	0	0	1	0	48	75										T	28302318	C	T	28302318	2	4	83	1	0	0	0	0	0	0	0	1	269	813	29	1		1	ADAMTS5	21	28302318	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		28302318	19827577	413	25257										
IFNGR2	3460	broad.mit.edu	37	chr21	34804515	34804515	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tttcagaagcaactccatttCattggataacttaaaaccct	4	10	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr21:34804515C>G	uc002yrp.3	+	5	1241	c.593C>G	c.(592-594)TCA>TGA	p.S198*	IFNGR2_uc002yrq.3_Nonsense_Mutation_p.S217*|IFNGR2_uc010gma.2_Nonsense_Mutation_p.S119*|IFNGR2_uc002yrr.3_Nonsense_Mutation_p.S119*	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	198	Extracellular (Potential).|Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	AACTCCATTTCATTGGATAAC	0.403													0	0	0	1	0	7	80										G	34804515	C	G	34804515	4	3	83	1	0	0	0	0	0	1	0	0	7550	838	29	1	611	1	IFNGR2	21	34804515	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	6502197	34804515	13325380	414	25258										
CECR6	27439	broad.mit.edu	37	chr22	17601328	17601328	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	accaccaggtcagtggcgatCcaggagcaccagtacaggtc	12	13	1	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:17601328C>T	uc002zmb.2	-	1	886	c.690G>A	c.(688-690)TGG>TGA	p.W230*	CECR6_uc002zma.2_Intron|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	230											0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		CAGTGGCGATCCAGGAGCACC	0.701													0	0	0	1	0	3	6										T	17601328	C	T	17601328	4	4	83	1	0	0	0	0	0	1	0	0	3208	856	30	1	1050	1	CECR6	22	17601328	Nonsense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		17601328	33703238	415	25259										
NF2	4771	broad.mit.edu	37	chr22	30057257	30057257	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggcttcacatttatgaccctGagaacagactgacccccaag	8	13	1	4			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:30057257G>T	uc003age.3	+	8	1182	c.739G>T	c.(739-741)GAG>TAG	p.E247*	NF2_uc003afy.3_Nonsense_Mutation_p.E247*|NF2_uc003afz.3_Nonsense_Mutation_p.E164*|NF2_uc003agf.3_Nonsense_Mutation_p.E247*|NF2_uc003agb.3_Nonsense_Mutation_p.E170*|NF2_uc003agc.3_Nonsense_Mutation_p.E209*|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Nonsense_Mutation_p.E247*|NF2_uc003aga.3_Nonsense_Mutation_p.E205*|NF2_uc003agh.3_Nonsense_Mutation_p.E206*|NF2_uc003agi.3_Nonsense_Mutation_p.E164*|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Nonsense_Mutation_p.E209*	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	247	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(1)|p.E247fs*4(1)|p.N226_E270del(1)|p.D245fs*31(1)|p.E247K(1)|p.L127_D382del(1)|p.L140_P252del(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						TTATGACCCTGAGAACAGACT	0.502			D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				1	0	4.00102e-26	1	4.2383e-26	42	45										T	30057257	G	T	30057257	4	4	83	1	0	0	0	0	0	1	0	0	10357	1291	45	3	769	3	NF2	22	30057257	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	12455929	30057257	21247309	416	25260										
EP300	2033	broad.mit.edu	37	chr22	41564578	41564580	+	In_Frame_Del	DEL	GAA	GAA	-													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgcttctgacaaaaccgtgGaagtaaaaccaggcatgaaa							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			GAA	-	GAA	GAA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:41564578_41564580delGAA	uc003azl.3	+	24	4395_4397	c.4000_4002delGAA	c.(4000-4002)GAAdel	p.E1334del		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1334					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CAAAACCGTGGAAGTAAAACCAG	0.429			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome									15	49	---	---								-	41564580	GAA	-	41564578	7	5	83	1	0	1	0	1	0	0	0	0	5148	1175	41	0	4094	0	EP300	22	41564578	In_Frame_Del	DEL	GAA	TCGA-FD-A3SO-01A-11D-A22Z-08	11507321	41564578	9739988	417	25261										
SCUBE1	80274	broad.mit.edu	37	chr22	43627846	43627846	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggtgttgcggcagaagtggtCgcagcctccgttgttgacca	15	10	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:43627846C>T	uc003bdt.1	-	8	968	c.880G>A	c.(880-882)GAC>AAC	p.D294N		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	294	EGF-like 7; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CAGAAGTGGTCGCAGCCTCCG	0.647											OREG0026615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	4	16										T	43627846	C	T	43627846	3	4	83	1	0	0	0	0	1	0	0	0	13944	884	31	1	2146	1	SCUBE1	22	43627846	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	2063268	43627846	7676720	418	25262										
MXRA5	25878	broad.mit.edu	37	chrX	3239561	3239561	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tatgcctgtctgtagcctccCaggctgggccgtccttgagg	13	13	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239561C>T	uc004crg.3	-	5	4322	c.4165G>A	c.(4165-4167)GGG>AGG	p.G1389R		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1389						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTAGCCTCCCAGGCTGGGCC	0.507													0	0	0	1	0	15	8										T	3239561	C	T	3239561	3	4	83	1	0	0	0	0	1	0	0	0	10003	594	21	2	4333	2	MXRA5	23	3239561	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08		3239561	152030999	419	25263										
MXRA5	25878	broad.mit.edu	37	chrX	3239741	3239741	+	Missense_Mutation	SNP	C	C	T													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gtcaacatttgtggcaacatCatccttaatttcttttccat					rs146955381	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239741C>T	uc004crg.3	-	5	4142	c.3985G>A	c.(3985-3987)GAT>AAT	p.D1329N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1329						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGGCAACATCATCCTTAATT	0.373													0	0	0	1	0	41	35										T	3239741	C	T	3239741	3	4	83	1	0	0	0	0	1	0	0	0	10003	826	29	1	4513	1	MXRA5	23	3239741	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	180	3239741	152030819	420	25264	126	2								
MXRA5	25878	broad.mit.edu	37	chrX	3239744	3239744	+	Missense_Mutation	SNP	C	C	T													0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aacatttgtggcaacatcatCcttaatttcttttccatctg							TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239744C>T	uc004crg.3	-	5	4139	c.3982G>A	c.(3982-3984)GAT>AAT	p.D1328N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1328						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCAACATCATCCTTAATTTCT	0.373													0	0	0	1	0	39	34										T	3239744	C	T	3239744	3	4	83	1	0	0	0	0	1	0	0	0	10003	855	30	1	4516	1	MXRA5	23	3239744	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	3	3239744	152030816	421	25265	126	2								
PIR	8544	broad.mit.edu	37	chrX	15474083	15474083	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	gaggctccaccatcttctctGagctcctcaaattaacccac	5	16	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:15474083G>C	uc004cwu.2	-	5	606	c.368C>G	c.(367-369)TCA>TGA	p.S123*	PIR_uc004cwv.2_Nonsense_Mutation_p.S123*	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	123					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					CATCTTCTCTGAGCTCCTCAA	0.527													0	0	0	1	0	24	146										C	15474083	G	C	15474083	4	2	83	1	0	0	0	0	0	1	0	0	11944	1294	45	1	528	1	PIR	23	15474083	Nonsense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	12234339	15474083	139796477	422	25266										
NHS	4810	broad.mit.edu	37	chrX	17750460	17750460	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tcgggcccctcctgcagccaGcagcagccgctacagtgtcc	11	18	0	0	rs140651691	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:17750460G>C	uc004cxx.2	+	8	5107	c.4769G>C	c.(4768-4770)AGC>ACC	p.S1590T	NHS_uc011mix.1_Missense_Mutation_p.S1611T|NHS_uc004cxy.2_Missense_Mutation_p.S1434T|NHS_uc004cxz.2_Missense_Mutation_p.S1413T|NHS_uc004cya.2_Missense_Mutation_p.S1313T	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1590						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCTGCAGCCAGCAGCAGCCGC	0.592													0	0	0	1	0	4	47										C	17750460	G	C	17750460	3	2	83	1	0	0	0	0	1	0	0	0	10411	971	34	4	4904	4	NHS	23	17750460	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	2276377	17750460	137520100	423	25267										
CACNA1F	778	broad.mit.edu	37	chrX	49065842	49065842	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ggacccaagtcctgcaggctCcgcagaccagcctgtggggg	15	14	0	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:49065842C>T	uc004dnb.2	-	42	4928	c.4866G>A	c.(4864-4866)CGG>CGA	p.R1622R	CACNA1F_uc010nip.2_Silent_p.R1611R	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1622	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CCTGCAGGCTCCGCAGACCAG	0.468													0	0	0	1	0	6	10										T	49065842	C	T	49065842	2	4	83	1	0	0	0	0	0	0	0	1	2543	842	30	1		1	CACNA1F	23	49065842	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	31315382	49065842	106204718	424	25268										
RRAGB	10325	broad.mit.edu	37	chrX	55784744	55784744	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	ttgaaaagctggaaagagtgGatggaccaaagcagtgtctt	13	5	1	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:55784744G>A	uc004dup.2	+	11	1744	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	RRAGB_uc004duq.2_Missense_Mutation_p.D337N	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	365					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						GGAAAGAGTGGATGGACCAAA	0.403													0	0	0	1	0	9	5										A	55784744	G	A	55784744	3	1	83	1	0	0	0	0	1	0	0	0	13673	1174	41	1	1135	1	RRAGB	23	55784744	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	6718902	55784744	99485816	425	25269										
ZNF75D	7626	broad.mit.edu	37	chrX	134425016	134425016	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggattcaataattgccactCttcctcagaaaaatacacag	5	10	3	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:134425016C>G	uc004eyp.2	-	6	3397	c.742G>C	c.(742-744)GAG>CAG	p.E248Q	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.E27Q|ZNF75D_uc004eyo.2_Missense_Mutation_p.E153Q	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	248	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATTGCCACTCTTCCTCAGAA	0.393													0	0	0	1	0	8	85										G	134425016	C	G	134425016	3	3	83	1	0	0	0	0	1	0	0	0	18131	922	32	1	798	1	ZNF75D	23	134425016	Missense_Mutation	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	78640272	134425016	20845544	426	25270										
SLC9A6	10479	broad.mit.edu	37	chrX	135126738	135126738	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	cgccccaaggagatttatggGaaacagttctgaagatgcct	11	9	1	3			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:135126738G>A	uc004ezj.2	+	16	1941	c.1865G>A	c.(1864-1866)GGA>GAA	p.G622E	SLC9A6_uc004ezk.2_Missense_Mutation_p.G654E	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	622					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AGATTTATGGGAAACAGTTCT	0.468													0	0	0	1	0	23	17										A	135126738	G	A	135126738	3	1	83	1	0	0	0	0	1	0	0	0	14718	1174	41	1	2023	1	SLC9A6	23	135126738	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	701722	135126738	20143822	427	25271										
GPR112	139378	broad.mit.edu	37	chrX	135428058	135428058	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	acaacagctgtatccaaattGacatcaccatggtttgctaa	6	10	1	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:135428058G>C	uc004ezu.1	+	6	2484	c.2193G>C	c.(2191-2193)TTG>TTC	p.L731F	GPR112_uc010nsb.1_Missense_Mutation_p.L526F|GPR112_uc010nsc.1_Missense_Mutation_p.L498F	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	731	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TATCCAAATTGACATCACCAT	0.398													0	0	0	1	0	29	17										C	135428058	G	C	135428058	3	2	83	1	0	0	0	0	1	0	0	0	6629	1281	45	1	2203	1	GPR112	23	135428058	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	301320	135428058	19842502	428	25272										
GPR101	83550	broad.mit.edu	37	chrX	136113174	136113174	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	tacagcagagcatgctgcctCcgggctgcacagaacaccac	10	15	0	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:136113174C>T	uc011mwh.1	-	1	660	c.660G>A	c.(658-660)CGG>CGA	p.R220R		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	220	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CATGCTGCCTCCGGGCTGCAC	0.537													0	0	0	1	0	33	22										T	136113174	C	T	136113174	2	4	83	1	0	0	0	0	0	0	0	1	6622	842	30	1		1	GPR101	23	136113174	Silent	SNP	C	TCGA-FD-A3SO-01A-11D-A22Z-08	685116	136113174	19157386	429	25273										
MAGEC1	9947	broad.mit.edu	37	chrX	140996131	140996131	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	atgtctttgtaaacacattaGacctcacctctgaggggtgt	9	9	3	2			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:140996131G>C	uc004fbt.2	+	4	3227	c.2941G>C	c.(2941-2943)GAC>CAC	p.D981H	MAGEC1_uc010nsl.1_Missense_Mutation_p.D48H	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	981	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAACACATTAGACCTCACCTC	0.468										HNSCC(15;0.026)			0	0	0	1	0	52	44										C	140996131	G	C	140996131	3	2	83	1	0	0	0	0	1	0	0	0	9180	942	33	1	2947	1	MAGEC1	23	140996131	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	4882957	140996131	14274429	430	25274										
GPR50	9248	broad.mit.edu	37	chrX	150349067	150349067	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aggcccgtaccctggcccgcGcccgtgcccatgctcgcgac	12	20	0	0			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:150349067G>A	uc010ntg.1	+	2	1147	c.1012G>A	c.(1012-1014)GCC>ACC	p.A338T	uc004fes.1_5'Flank|GPR50_uc011myc.1_3'UTR	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	338	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGCCCGCGCCCGTGCCCA	0.567													0	0	0	1	0	8	95										A	150349067	G	A	150349067	3	1	83	1	0	0	0	0	1	0	0	0	6697	1087	38	2	1018	2	GPR50	23	150349067	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08	9352936	150349067	4921493	431	25275										
RPS4Y2	140032	broad.mit.edu	37	chrY	22918664	22918664	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.555813953488372	239	1.93660286053078e-88	3.9718138869005	4.70076033057851	3.58538444687842	0.000168760165615862	0.000914117563752586	179	aagtttggtgtctttttcagGcccggggccccaagaagcac	12	11	2	1			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrY:22918664G>A	uc011nbb.1	+	2	100	c.4G>A	c.(4-6)GCC>ACC	p.A2T		NM_001039567	NP_001034656	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	2					translation	ribosome	rRNA binding|structural constituent of ribosome				0						TCTTTTTCAGGCCCGGGGCCC	0.433													0	0	0	1	0	6	10										A	22918664	G	A	22918664	3	1	83	1	0	0	0	0	1	0	0	0	13647	1217	42	2	10	2	RPS4Y2	24	22918664	Missense_Mutation	SNP	G	TCGA-FD-A3SO-01A-11D-A22Z-08		22918664	36454902	432	25276										
VPS13D	55187	broad.mit.edu	37	chr1	12460316	12460316	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcaatgagaatgaggtcatcGagaccggcccagctgtgcaa	13	10	1	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:12460316G>A	uc001atv.2	+	61	11854	c.11713G>A	c.(11713-11715)GAG>AAG	p.E3905K	VPS13D_uc001atw.2_Missense_Mutation_p.E3880K|VPS13D_uc001atx.2_Missense_Mutation_p.E3092K|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3904					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGAGGTCATCGAGACCGGCCC	0.552													0	0	0	0.024245	0	14	32										A	12460316	G	A	12460316	3	1	84	1	0	0	0	0	1	0	0	0	17189	1059	37	1	11951	1	VPS13D	1	12460316	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		12460316	236790305	1	25277										
CASP9	842	broad.mit.edu	37	chr1	15831211	15831211	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctcgaccgacacagggcatcCatctgtgccgtagacagccc	10	16	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:15831211C>T	uc001awn.2	-	6	858	c.763G>A	c.(763-765)GGA>AGA	p.G255R	CASP9_uc001awm.1_Missense_Mutation_p.G255R|CASP9_uc001awo.2_Intron|CASP9_uc001awp.2_Missense_Mutation_p.G99R|CASP9_uc009voi.2_Missense_Mutation_p.G99R|CASP9_uc010obm.1_Missense_Mutation_p.G172R|CASP9_uc001awq.2_Missense_Mutation_p.G172R	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein	255					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		ACAGGGCATCCATCTGTGCCG	0.552													0	0	0	0.028581	0	15	63										T	15831211	C	T	15831211	3	4	84	1	0	0	0	0	1	0	0	0	2679	603	21	2	503	2	CASP9	1	15831211	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	3370895	15831211	233419410	2	25278										
ARID1A	8289	broad.mit.edu	37	chr1	27101322	27101326	+	Frame_Shift_Del	DEL	CAGAT	CAGAT	-													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aacagatgaaatgctgcacaCagatcagagggccaaccacg							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			CAGAT	-	CAGAT	CAGAT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:27101322_27101326delCAGAT	uc001bmv.1	+	18	4977_4981	c.4604_4608delCAGAT	c.(4603-4608)ACAGATfs	p.T1535fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.T1534fs|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Frame_Shift_Del_p.T1152fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.T381fs|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1535_1536					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATGCTGCACACAGATCAGAGGGCCA	0.605			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													13	76	---	---								-	27101326	CAGAT	-	27101322	7	5	84	1	0	1	0	1	0	0	0	0	913	478	17	0	4674	0	ARID1A	1	27101322	Frame_Shift_Del	DEL	CAGAT	TCGA-FD-A3SP-01A-31D-A22Z-08	11270111	27101322	222149299	3	25279										
PTPRF	5792	broad.mit.edu	37	chr1	44086513	44086513	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cacccacctttcccaggatgGgcagtcaaggacaatccggc	10	15	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:44086513G>A	uc001cjr.2	+	32	5709	c.5369G>A	c.(5368-5370)GGG>GAG	p.G1790E	PTPRF_uc001cjs.2_Missense_Mutation_p.G1781E|PTPRF_uc001cju.2_Missense_Mutation_p.G1179E|PTPRF_uc009vwt.2_Missense_Mutation_p.G1350E|PTPRF_uc001cjv.2_Missense_Mutation_p.G1261E|PTPRF_uc001cjw.2_Missense_Mutation_p.G1016E	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1790	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCCCAGGATGGGCAGTCAAGG	0.557													0	0	0	0.013537	0	12	36										A	44086513	G	A	44086513	3	1	84	1	0	0	0	0	1	0	0	0	12801	1232	43	2	5487	2	PTPRF	1	44086513	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	16985191	44086513	205164108	4	25280										
CYP4Z1	199974	broad.mit.edu	37	chr1	47548040	47548040	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	accctggatggttctaaatgGaaaaagcaccgccagattgt	10	9	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:47548040G>A	uc001cqu.1	+	4	402	c.399G>A	c.(397-399)TGG>TGA	p.W133*		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	133	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						GTTCTAAATGGAAAAAGCACC	0.458													0	0	0	0.004482	0	7	41										A	47548040	G	A	47548040	4	1	84	1	0	0	0	0	0	1	0	0	4194	1183	41	1	413	1	CYP4Z1	1	47548040	Nonsense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	3461527	47548040	201702581	5	25281										
LRRC7	57554	broad.mit.edu	37	chr1	70504189	70504189	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	agtccgtttgaagacaggacCgcttttccttccaaattaga	8	10	0	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:70504189C>T	uc001dep.2	+	19	2598	c.2568C>T	c.(2566-2568)ACC>ACT	p.T856T	LRRC7_uc009wbg.2_Silent_p.T140T|LRRC7_uc001deq.2_Silent_p.T97T	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	856						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AAGACAGGACCGCTTTTCCTT	0.463													0	0	0	0.016723	0	13	154										T	70504189	C	T	70504189	2	4	84	1	0	0	0	0	0	0	0	1	9020	639	23	2		2	LRRC7	1	70504189	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	22956149	70504189	178746432	6	25282										
ZZZ3	26009	broad.mit.edu	37	chr1	78098224	78098224	+	Frame_Shift_Del	DEL	T	T	-													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tcctccaacttgacctgcacTtgtgaatctgtgcaaggcac							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:78098224delT	uc001dhq.2	-	5	1292	c.816delA	c.(814-816)CAAfs	p.Q272fs	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Frame_Shift_Del_p.Q272fs|ZZZ3_uc001dhp.2_Frame_Shift_Del_p.Q272fs	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TGACCTGCACTTGTGAATCTG	0.458																		37	246	---	---								-	78098224	T	-	78098224	7	5	84	1	0	1	0	1	0	0	0	0	18253	1606	56	0	1939	0	ZZZ3	1	78098224	Frame_Shift_Del	DEL	T	TCGA-FD-A3SP-01A-31D-A22Z-08	7594035	78098224	171152397	7	25283										
GBP1	2633	broad.mit.edu	37	chr1	89523877	89523877	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gggaagaatttccggatacaGagtctgggcaggttaaaagt	14	5	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:89523877G>C	uc001dmx.2	-	6	892	c.672C>G	c.(670-672)CTC>CTG	p.L224L		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	224					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCCGGATACAGAGTCTGGGCA	0.358													0	0	0	0.016522	0	22	395										C	89523877	G	C	89523877	2	2	84	1	0	0	0	0	0	0	0	1	6273	929	33	1		1	GBP1	1	89523877	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	11425653	89523877	159726744	8	25284										
CELSR2	1952	broad.mit.edu	37	chr1	109793320	109793320	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttgcatccctgagggccatcGacccggacgagggtgaggca	15	12	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:109793320G>C	uc001dxa.3	+	1	680	c.619G>C	c.(619-621)GAC>CAC	p.D207H		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	207	Cadherin 1.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GAGGGCCATCGACCCGGACGA	0.617													0	0	0	0.014758	0	5	59										C	109793320	G	C	109793320	3	2	84	1	0	0	0	0	1	0	0	0	3222	1058	37	1	621	1	CELSR2	1	109793320	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	20269443	109793320	139457301	9	25285										
GPR89A	653519	broad.mit.edu	37	chr1	145771648	145771648	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cacttacatcaaattggattCccagataattcacagtgatc	5	10	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:145771648C>T	uc001eot.2	-	11	1166	c.992G>A	c.(991-993)GGA>GAA	p.G331E	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Missense_Mutation_p.G29E|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Missense_Mutation_p.G255E|GPR89A_uc010ozb.1_Missense_Mutation_p.G306E|GPR89A_uc001eos.2_Missense_Mutation_p.G211E|GPR89A_uc010ozc.1_Missense_Mutation_p.G306E|GPR89A_uc010ozd.1_Missense_Mutation_p.G278E|GPR89A_uc010oze.1_Missense_Mutation_p.G331E	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	331					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			AAATTGGATTCCCAGATAATT	0.343													0	0	0	0.013537	0	9	105										T	145771648	C	T	145771648	3	4	84	1	0	0	0	0	1	0	0	0	6718	855	30	1	391	1	GPR89A	1	145771648	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	35978328	145771648	103478973	10	25286										
RFX5	5993	broad.mit.edu	37	chr1	151315450	151315450	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tttcagggcacctgaagaaaGcctgggggccagaataggtg	15	8	1	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:151315450G>T	uc001exv.1	-	11	1277	c.1063C>A	c.(1063-1065)CTT>ATT	p.L355I	RFX5_uc001exw.1_Missense_Mutation_p.L355I|RFX5_uc009wmr.1_Missense_Mutation_p.L355I|RFX5_uc010pcx.1_Missense_Mutation_p.L315I	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5	355						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTGAAGAAAGCCTGGGGGCC	0.587													1	0	3.03607e-14	0.013537	3.38016e-14	13	60										T	151315450	G	T	151315450	3	4	84	1	0	0	0	0	1	0	0	0	13266	971	34	4	791	4	RFX5	1	151315450	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	5543802	151315450	97935171	11	25287										
FLG	2312	broad.mit.edu	37	chr1	152282251	152282251	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttccactgtctccgactacaGatgaatcttgtctgcgccca	7	14	3	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:152282251G>C	uc001ezu.1	-	3	5147	c.5111C>G	c.(5110-5112)TCT>TGT	p.S1704C		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1704	Ser-rich.|Filaggrin 10.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCGACTACAGATGAATCTTG	0.572									Ichthyosis				0	0	0	0.013114	0	30	349										C	152282251	G	C	152282251	3	2	84	1	0	0	0	0	1	0	0	0	5922	942	33	1	7078	1	FLG	1	152282251	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	966801	152282251	96968370	12	25288										
NTRK1	4914	broad.mit.edu	37	chr1	156845927	156845927	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aagtgggagctgggggagggCgcctttgggaaggtcttcct	19	7	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:156845927C>T	uc001fqh.1	+	13	1613	c.1557C>T	c.(1555-1557)GGC>GGT	p.G519G	NTRK1_uc001fqf.1_Silent_p.G483G|NTRK1_uc009wsi.1_Silent_p.G218G|NTRK1_uc001fqi.1_Silent_p.G513G|NTRK1_uc009wsk.1_Silent_p.G516G	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	519	Cytoplasmic (Potential).|ATP (By similarity).|Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGGGGAGGGCGCCTTTGGGA	0.632			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			0	0	0	0.014758	0	5	69										T	156845927	C	T	156845927	2	4	84	1	0	0	0	0	0	0	0	1	10706	755	27	2		2	NTRK1	1	156845927	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	4563676	156845927	92404694	13	25289										
FCRL5	83416	broad.mit.edu	37	chr1	157514227	157514227	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctgaagaagcggaaccggagCgggacatctgacctctctag	13	11	2	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:157514227C>T	uc001fqu.2	-	5	827	c.669G>A	c.(667-669)CCG>CCA	p.P223P	FCRL5_uc009wsm.2_Silent_p.P223P|FCRL5_uc010phv.1_Silent_p.P223P|FCRL5_uc010phw.1_Silent_p.P138P|FCRL5_uc001fqv.1_Silent_p.P223P|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	223	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GGAACCGGAGCGGGACATCTG	0.567													0	0	0	0.008871	0	19	114										T	157514227	C	T	157514227	2	4	84	1	0	0	0	0	0	0	0	1	5798	755	27	2		2	FCRL5	1	157514227	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	668300	157514227	91736394	14	25290										
OR10R2	343406	broad.mit.edu	37	chr1	158449927	158449927	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cttcttccttggcattctctCaacatctgagaccttctaca	4	14	5	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:158449927C>G	uc010pik.1	+	1	260	c.260C>G	c.(259-261)TCA>TGA	p.S87*	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	87	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					GGCATTCTCTCAACATCTGAG	0.433													0	0	0	0.024334	0	27	172										G	158449927	C	G	158449927	4	3	84	1	0	0	0	0	0	1	0	0	10917	838	29	1	262	1	OR10R2	1	158449927	Nonsense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	935700	158449927	90800694	15	25291										
RCOR3	55758	broad.mit.edu	37	chr1	211433478	211433478	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atgagagtcggagccgaataCcaagctcggatccctgaatt	11	10	0	2	rs145681038	byFrequency	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:211433478C>A	uc001hig.2	+	1	190	c.21C>A	c.(19-21)TAC>TAA	p.Y7*	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Nonsense_Mutation_p.Y65*|RCOR3_uc010psw.1_Nonsense_Mutation_p.Y65*|RCOR3_uc001hif.2_Nonsense_Mutation_p.Y65*	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	7	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		GAGCCGAATACCAAGCTCGGA	0.353													1	0	9.39395e-14	0.00632	1.03893e-13	25	27										A	211433478	C	A	211433478	4	1	84	1	0	0	0	0	0	1	0	0	13184	518	18	4	201	4	RCOR3	1	211433478	Nonsense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	52983551	211433478	37817143	16	25292										
OR2L3	391192	broad.mit.edu	37	chr1	248224518	248224518	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccatcaatcatttcttctgtGatgtcccagcaatggtgact	7	11	4	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:248224518G>A	uc001idx.1	+	1	535	c.535G>A	c.(535-537)GAT>AAT	p.D179N	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTTCTTCTGTGATGTCCCAGC	0.478													0	0	0	0.008361	0	30	135										A	248224518	G	A	248224518	3	1	84	1	0	0	0	0	1	0	0	0	11008	1290	45	1	537	1	OR2L3	1	248224518	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	36791040	248224518	1026103	17	25293										
OR2T10	127069	broad.mit.edu	37	chr1	248756267	248756267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atgacatcatatctttctcaGgagtttggtaggagctgggg	13	6	3	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:248756267G>A	uc010pzn.1	-	1	803	c.803C>T	c.(802-804)CCT>CTT	p.P268L		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCTTTCTCAGGAGTTTGGTA	0.438													0	0	0	0.008291	0	10	53										A	248756267	G	A	248756267	3	1	84	1	0	0	0	0	1	0	0	0	11017	1000	35	2	138	2	OR2T10	1	248756267	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	531749	248756267	494354	18	25294										
SDC1	6382	broad.mit.edu	37	chr2	20405159	20405160	+	Frame_Shift_Ins	INS	-	-	G													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cagagccatcttgatcttcaINSgggggcaaattagtagccac							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:20405159_20405160insG	uc002rdo.1	-	2	391_392	c.92_93insC	c.(91-93)CCTfs	p.P31fs	SDC1_uc002rdp.1_Frame_Shift_Ins_p.P31fs|SDC1_uc010exv.2_Frame_Shift_Ins_p.P31fs|SDC1_uc010exw.1_RNA	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	31	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CTTGATCTTCAGGGGGCAAATT	0.55																		7	106	---	---								G	20405160	-	G	20405159	7	5	84	1	0	1	1	0	0	0	0	0	13951	175	7	0	855	0	SDC1	2	20405159	Frame_Shift_Ins	INS	-	TCGA-FD-A3SP-01A-31D-A22Z-08		20405159	222794214	19	25295										
DYNC2LI1	51626	broad.mit.edu	37	chr2	44023913	44023913	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	acacttcgatttgttgcacaTtattatggagcatcattaat	6	7	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:44023913T>G	uc002rtk.2	+	8	729	c.633T>G	c.(631-633)CAT>CAG	p.H211Q	DYNC2LI1_uc002rtj.2_Missense_Mutation_p.H211Q|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.H212Q|DYNC2LI1_uc010ynz.1_Missense_Mutation_p.H85Q	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	211						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTGTTGCACATTATTATGGAG	0.353													0	0	0	0.00499	0	15	59										G	44023913	T	G	44023913	3	3	84	1	0	0	0	0	1	0	0	0	4847	1490	52	5	762	5	DYNC2LI1	2	44023913	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	23618754	44023913	199175460	20	25296										
SMYD5	10322	broad.mit.edu	37	chr2	73446021	73446021	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tttgccacacagctcatccgGaagggggagaccatcttcgt	11	12	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:73446021G>A	uc002siw.2	+	2	158	c.129G>A	c.(127-129)CGG>CGA	p.R43R	SMYD5_uc010yre.1_5'UTR	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	43							metal ion binding				0						AGCTCATCCGGAAGGGGGAGA	0.542													0	0	0	0.008291	0	10	42										A	73446021	G	A	73446021	2	1	84	1	0	0	0	0	0	0	0	1	14825	1161	41	1		1	SMYD5	2	73446021	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	29422108	73446021	169753352	21	25297										
ST6GAL2	84620	broad.mit.edu	37	chr2	107446656	107446656	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggtttctctgacgatgctgaAtatatggagtgaacaggttg	13	5	1	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:107446656A>C	uc002tdq.2	-	5	1303	c.1184T>G	c.(1183-1185)ATT>AGT	p.I395S	ST6GAL2_uc002tdr.2_Missense_Mutation_p.I395S|ST6GAL2_uc002tds.3_Missense_Mutation_p.I395S	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	395	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						ACGATGCTGAATATATGGAGT	0.368													0	0	0	0.008871	0	20	86										C	107446656	A	C	107446656	3	2	84	1	0	0	0	0	1	0	0	0	15221	101	4	5	500	5	ST6GAL2	2	107446656	Missense_Mutation	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08	34000635	107446656	135752717	22	25298										
RANBP2	5903	broad.mit.edu	37	chr2	109400167	109400167	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tggtttactatccatggccaAtcaaggccagaataccaata	7	10	1	1	rs141352150		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:109400167A>G	uc002tem.3	+	29	9611	c.9485A>G	c.(9484-9486)AAT>AGT	p.N3162S		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	3162	PPIase cyclophilin-type.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TCCATGGCCAATCAAGGCCAG	0.368													0	0	0	0.010729	0	10	88										G	109400167	A	G	109400167	3	3	84	1	0	0	0	0	1	0	0	0	13028	101	4	5	9599	5	RANBP2	2	109400167	Missense_Mutation	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08	1953511	109400167	133799206	23	25299										
PSD4	23550	broad.mit.edu	37	chr2	113940254	113940254	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctccggtgtggagctcacacAcctggggagctgggtccatc	14	13	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:113940254A>G	uc002tjc.2	+	2	404	c.221A>G	c.(220-222)CAC>CGC	p.H74R	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.H73R|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	74					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GAGCTCACACACCTGGGGAGC	0.617													0	0	0	0.014758	0	5	41										G	113940254	A	G	113940254	3	3	84	1	0	0	0	0	1	0	0	0	12649	159	6	5	223	5	PSD4	2	113940254	Missense_Mutation	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08	4540087	113940254	129259119	24	25300										
XIRP2	129446	broad.mit.edu	37	chr2	168101824	168101824	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctgaagaagtaatacagggtGatgtaaaaagctacagaatg	11	4	0	4			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:168101824G>A	uc002udx.2	+	8	3940	c.3922G>A	c.(3922-3924)GAT>AAT	p.D1308N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D1133N|XIRP2_uc010fpq.2_Missense_Mutation_p.D1086N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1133	Xin 22.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AATACAGGGTGATGTAAAAAG	0.368													0	0	0	0.016723	0	14	73										A	168101824	G	A	168101824	3	1	84	1	0	0	0	0	1	0	0	0	17427	1290	45	1	3952	1	XIRP2	2	168101824	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	54161570	168101824	75097549	25	25301										
TTN	7273	broad.mit.edu	37	chr2	179542881	179542881	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtggtgcttccacttttttcGgaacaggtgttggtttcttt	11	7	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:179542881G>A	uc010zfg.1	-	142	30457	c.30233C>T	c.(30232-30234)CCG>CTG	p.P10078L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6739L|TTN_uc010fre.1_Missense_Mutation_p.P735L|TTN_uc002una.1_RNA|TTN_uc010frf.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11005							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTTTTTTCGGAACAGGTGT	0.358													0	0	0	0.004482	0	7	79										A	179542881	G	A	179542881	3	1	84	1	0	0	0	0	1	0	0	0	16732	1116	39	2	70436	2	TTN	2	179542881	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	11441057	179542881	63656492	26	25302										
CYP20A1	57404	broad.mit.edu	37	chr2	204144831	204144831	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggccagttgcataataactgCaaaatgtaagtataaattga	8	5	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:204144831C>A	uc002uzv.3	+	8	1467	c.845C>A	c.(844-846)GCA>GAA	p.A282E	CYP20A1_uc002uzx.3_Missense_Mutation_p.A180E|CYP20A1_uc010zif.1_Missense_Mutation_p.A290E|CYP20A1_uc002uzy.3_Missense_Mutation_p.A180E|CYP20A1_uc002uzw.3_RNA|CYP20A1_uc010ftw.2_Missense_Mutation_p.A12E	NM_177538	NP_803882	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A,	282						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0						ATAATAACTGCAAAATGTAAG	0.219													1	0	5.68852e-11	0.004482	6.24989e-11	8	20										A	204144831	C	A	204144831	3	1	84	1	0	0	0	0	1	0	0	0	4152	710	25	4	875	4	CYP20A1	2	204144831	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	24601950	204144831	39054542	27	25303										
VIL1	7429	broad.mit.edu	37	chr2	219292748	219292748	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gagaccaactcctatgacgtCcagaggctgctgcatgtcaa	10	12	1	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:219292748C>T	uc002via.2	+	5	473	c.408C>T	c.(406-408)GTC>GTT	p.V136V	VIL1_uc010zke.1_Intron|VIL1_uc002vib.2_Silent_p.V136V|VIL1_uc002vic.1_Silent_p.V136V	NM_007127	NP_009058	P09327	VILI_HUMAN	villin 1	136	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTATGACGTCCAGAGGCTGC	0.622													0	0	0	0.014323	0	19	146										T	219292748	C	T	219292748	2	4	84	1	0	0	0	0	0	0	0	1	17161	842	30	1		1	VIL1	2	219292748	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	15147917	219292748	23906625	28	25304										
PAX3	5077	broad.mit.edu	37	chr2	223096999	223096999	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cttcatctgattggggtgctGaggctaaaagcacagaagaa	12	7	2	4			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:223096999G>A	uc010fwo.2	-	5	956	c.590C>T	c.(589-591)TCA>TTA	p.S197L	PAX3_uc002vmt.1_Missense_Mutation_p.S197L|PAX3_uc002vmy.1_Missense_Mutation_p.S196L|PAX3_uc002vmv.1_Missense_Mutation_p.S197L|PAX3_uc002vmw.1_Missense_Mutation_p.S197L|PAX3_uc002vmx.1_Missense_Mutation_p.S197L	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	197					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGGGGTGCTGAGGCTAAAAG	0.328			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						0	0	0	0.006214	0	10	92										A	223096999	G	A	223096999	3	1	84	1	0	0	0	0	1	0	0	0	11480	1294	45	1	979	1	PAX3	2	223096999	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	3804251	223096999	20102374	29	25305										
KIAA1486	57624	broad.mit.edu	37	chr2	226447640	226447640	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gggcagccccgggtggctccCggtcccggacacccacgagc	15	18	0	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:226447640C>T	uc002voe.2	+	4	1682	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.R273W	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	503										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GGGTGGCTCCCGGTCCCGGAC	0.687													0	0	0	0.001984	0	6	24										T	226447640	C	T	226447640	3	4	84	1	0	0	0	0	1	0	0	0	8237	643	23	2	1517	2	KIAA1486	2	226447640	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	3350641	226447640	16751733	30	25306										
COL6A3	1293	broad.mit.edu	37	chr2	238296565	238296565	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tccaccacgaaatcaagggcGaggccgatattggccaactc	10	13	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:238296565G>A	uc002vwl.2	-	4	1257	c.972C>T	c.(970-972)CTC>CTT	p.L324L	COL6A3_uc002vwo.2_Silent_p.L118L|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Silent_p.L118L|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Silent_p.L324L	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	324	VWFA 2.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AATCAAGGGCGAGGCCGATAT	0.617													0	0	0	0.001984	0	7	41										A	238296565	G	A	238296565	2	1	84	1	0	0	0	0	0	0	0	1	3701	1045	37	1		1	COL6A3	2	238296565	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	11848925	238296565	4902808	31	25307										
RARB	5915	broad.mit.edu	37	chr3	25216052	25216053	+	Frame_Shift_Del	DEL	CC	CC	-													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcctccgagtggatgcagcaCcccgtcgccggcaagtaagt							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:25216052_25216053delCC	uc011awl.1	+	1	230_231	c.164_165delCC	c.(163-165)ACCfs	p.T55fs		NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	55	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	GGATGCAGCACCCCGTCGCCGG	0.559																		13	42	---	---								-	25216053	CC	-	25216052	7	5	84	1	0	1	0	1	0	0	0	0	13053	522	18	0		0	RARB	3	25216052	Frame_Shift_Del	DEL	CC	TCGA-FD-A3SP-01A-31D-A22Z-08		25216052	172806378	32	25308										
RARB	5915	broad.mit.edu	37	chr3	25542729	25542729	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tacacttgtcaccgagataaGaactgtgttattaataaagt	7	6	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:25542729G>C	uc011awl.1	+	3	450	c.384G>C	c.(382-384)AAG>AAC	p.K128N	RARB_uc003cdi.1_Missense_Mutation_p.K9N|RARB_uc003cdh.2_Missense_Mutation_p.K121N	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	128	Nuclear receptor.|NR C4-type.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	ACCGAGATAAGAACTGTGTTA	0.393													0	0	0	0.006214	0	8	90										C	25542729	G	C	25542729	3	2	84	1	0	0	0	0	1	0	0	0	13053	933	33	1	373	1	RARB	3	25542729	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	326677	25542729	172479701	33	25309										
OXSM	54995	broad.mit.edu	37	chr3	25835785	25835785	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgggagctgcaggggcagtcGaggcagcttttaccacatta	14	9	0	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:25835785G>A	uc003cdn.2	+	3	1287	c.1180G>A	c.(1180-1182)GAG>AAG	p.E394K	OXSM_uc011awp.1_Missense_Mutation_p.E119K|OXSM_uc010hfh.2_Missense_Mutation_p.E311K	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	394					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						AGGGGCAGTCGAGGCAGCTTT	0.438													0	0	0	0.024245	0	16	88										A	25835785	G	A	25835785	3	1	84	1	0	0	0	0	1	0	0	0	11335	1059	37	1	1186	1	OXSM	3	25835785	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	293056	25835785	172186645	34	25310										
SLC6A20	54716	broad.mit.edu	37	chr3	45800507	45800507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cgtctcccctcttgaggcgaCgctgaacaaaagtccccagg	10	15	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:45800507C>T	uc011bai.1	-	11	1866	c.1742G>A	c.(1741-1743)CGT>CAT	p.R581H	SLC6A20_uc003cow.2_Missense_Mutation_p.R231H|SLC6A20_uc011baj.1_Missense_Mutation_p.R544H	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	581	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CTTGAGGCGACGCTGAACAAA	0.602													0	0	0	0.013537	0	13	43										T	45800507	C	T	45800507	3	4	84	1	0	0	0	0	1	0	0	0	14684	536	19	2	40	2	SLC6A20	3	45800507	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	19964722	45800507	152221923	35	25311										
ALS2CL	259173	broad.mit.edu	37	chr3	46714826	46714827	+	Splice_Site	DEL	CA	CA	-													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tggggctctggcctccctctCacctgattgctcgtcagcgt							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:46714826_46714827delCA	uc003cqa.1	-	22	2662	c.2472_splice	c.e22+1	p.Q824_splice	ALS2CL_uc003cpx.1_Splice_Site_p.Q171_splice|ALS2CL_uc003cpy.1_Splice_Site|ALS2CL_uc003cpz.1_Splice_Site_p.Q339_splice|ALS2CL_uc003cqb.1_Splice_Site_p.Q824_splice|ALS2CL_uc003cqc.1_Splice_Site	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1						endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GCCTCCCTCTCACCTGATTGCT	0.609																		2	4	---	---								-	46714827	CA	-	46714826	8	5	84	1	0	1	0	1	0	0	1	0	551	841	29	0		0	ALS2CL	3	46714826	Splice_Site	DEL	CA	TCGA-FD-A3SP-01A-31D-A22Z-08	914319	46714826	151307604	36	25312										
MAP4	4134	broad.mit.edu	37	chr3	47908773	47908773	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	catgcttaatattgtccttgGaaccacacttggactgaata	7	9	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:47908773G>A	uc003csb.2	-	15	3555	c.3029C>T	c.(3028-3030)TCC>TTC	p.S1010F	MAP4_uc003csc.3_Missense_Mutation_p.S1010F|MAP4_uc003crw.2_Missense_Mutation_p.S89F|MAP4_uc003crx.2_Intron|MAP4_uc011bbe.1_Missense_Mutation_p.S723F|MAP4_uc003cry.2_Missense_Mutation_p.S745F|MAP4_uc003csa.3_Intron|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.S730F	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	1010	Tau/MAP 2.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		ATTGTCCTTGGAACCACACTT	0.438													0	0	0	0.016723	0	13	92										A	47908773	G	A	47908773	3	1	84	1	0	0	0	0	1	0	0	0	9258	1174	41	1	600	1	MAP4	3	47908773	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	1193947	47908773	150113657	37	25313										
CELSR3	1951	broad.mit.edu	37	chr3	48694483	48694483	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aactgctcctgcagctcctcGgagctgaaccagggccctgc	11	16	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:48694483G>A	uc003cul.2	-	2	4328	c.4047C>T	c.(4045-4047)TCC>TCT	p.S1349S	CELSR3_uc003cuf.1_Silent_p.S1419S	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1349	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCAGCTCCTCGGAGCTGAACC	0.682													0	0	0	0.014758	0	5	40										A	48694483	G	A	48694483	2	1	84	1	0	0	0	0	0	0	0	1	3223	1103	39	2		2	CELSR3	3	48694483	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	785710	48694483	149327947	38	25314										
QARS	5859	broad.mit.edu	37	chr3	49136834	49136834	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccccgccgtcgcagggccgtGagtgtaaagagccgtgggtc	16	13	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:49136834G>A	uc003cvx.2	-	17	1562	c.1557C>T	c.(1555-1557)CTC>CTT	p.L519L	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Silent_p.L374L|QARS_uc003cvy.2_Silent_p.L374L|QARS_uc011bce.1_Silent_p.L508L	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	519					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GCAGGGCCGTGAGTGTAAAGA	0.557													0	0	0	0.006214	0	10	70										A	49136834	G	A	49136834	2	1	84	1	0	0	0	0	0	0	0	1	12871	1277	45	1		1	QARS	3	49136834	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	442351	49136834	148885596	39	25315										
GPX1	2876	broad.mit.edu	37	chr3	49394857	49394857	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccttgagacagcagggcttcGatgtcaggctcgatgtcaat	12	10	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:49394857G>T	uc011bcl.1	-	3	656	c.576C>A	c.(574-576)ATC>ATA	p.I192I	GPX1_uc011bcm.1_3'UTR	NM_000581	NP_000572	P07203	GPX1_HUMAN	glutathione peroxidase 1 isoform 1	192					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	GCAGGGCTTCGATGTCAGGCT	0.617													1	0	2.7689e-08	0.001984	2.96414e-08	7	45										T	49394857	G	T	49394857	2	4	84	1	0	0	0	0	0	0	0	1	6739	1048	37	3		3	GPX1	3	49394857	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	258023	49394857	148627573	40	25316										
FAM116A	201627	broad.mit.edu	37	chr3	57658153	57658153	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtcagtaagtttggaatgctGaggataaattacctggaaga	12	4	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:57658153G>A	uc003dja.2	-	2	321	c.250C>T	c.(250-252)CAG>TAG	p.Q84*		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	84										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		TTGGAATGCTGAGGATAAATT	0.204													0	0	0	0.004482	0	7	57										A	57658153	G	A	57658153	4	1	84	1	0	0	0	0	0	1	0	0	5407	1299	45	1	1652	1	FAM116A	3	57658153	Nonsense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	8263296	57658153	140364277	41	25317										
MRPL3	11222	broad.mit.edu	37	chr3	131190094	131190094	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggcctttaaatccccatcttTtcatgacaccttgaaaacct	4	13	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:131190094T>C	uc003eoh.2	-	7	823	c.659A>G	c.(658-660)AAA>AGA	p.K220R	MRPL3_uc011blo.1_Missense_Mutation_p.K115R|MRPL3_uc011blp.1_Missense_Mutation_p.K247R	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	220					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						TCCCCATCTTTTCATGACACC	0.408													0	0	0	0.004482	0	9	83										C	131190094	T	C	131190094	3	2	84	1	0	0	0	0	1	0	0	0	9793	1841	64	5	403	5	MRPL3	3	131190094	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	73531941	131190094	66832336	42	25318										
DGKG	1608	broad.mit.edu	37	chr3	186006620	186006620	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	acggggggttccaggggggtCgcagccacttggtcttcagc	17	11	2	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:186006620C>T	uc003fqa.2	-	6	960	c.423G>A	c.(421-423)GCG>GCA	p.A141A	DGKG_uc003fqb.2_Silent_p.A141A|DGKG_uc003fqc.2_Silent_p.A141A|DGKG_uc011brx.1_Silent_p.A141A	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	141					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCAGGGGGGTCGCAGCCACTT	0.512													0	0	0	0.01441	0	47	180										T	186006620	C	T	186006620	2	4	84	1	0	0	0	0	0	0	0	1	4469	871	31	1		1	DGKG	3	186006620	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	54816526	186006620	12015810	43	25319										
INPP4B	8821	broad.mit.edu	37	chr4	143044482	143044482	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccttcatattgtactatcaaCcccactgtgtgaagctgctg	7	12	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr4:143044482C>A	uc003iix.3	-	21	2575	c.1980G>T	c.(1978-1980)GGG>GGT	p.G660G	INPP4B_uc003iiw.3_Silent_p.G660G|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Silent_p.G475G|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Silent_p.G531G	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	660					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GTACTATCAACCCCACTGTGT	0.363													1	0	3.09899e-07	0.004482	3.25491e-07	8	85										A	143044482	C	A	143044482	2	1	84	1	0	0	0	0	0	0	0	1	7753	494	18	4		4	INPP4B	4	143044482	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08		143044482	48109794	44	25320										
DAB2	1601	broad.mit.edu	37	chr5	39377092	39377092	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtggacacagcaggagctggAaaaatattgctctgaaaagg	13	6	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:39377092A>G	uc003jlx.2	-	12	2328	c.1797T>C	c.(1795-1797)TTT>TTC	p.F599F	DAB2_uc003jlw.2_Silent_p.F578F	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	599					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CAGGAGCTGGAAAAATATTGC	0.572											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	11	151										G	39377092	A	G	39377092	2	3	84	1	0	0	0	0	0	0	0	1	4218	243	9	5		5	DAB2	5	39377092	Silent	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08		39377092	141538168	45	25321										
SLC27A6	28965	broad.mit.edu	37	chr5	128368806	128368806	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aattgctttacaggaaaaaaTggaagcaacaggaacattca	8	6	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:128368806T>A	uc003kuy.2	+	11	2087	c.1691T>A	c.(1690-1692)ATG>AAG	p.M564K	SLC27A6_uc003kuz.2_Missense_Mutation_p.M564K	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	564					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CAGGAAAAAATGGAAGCAACA	0.289													0	0	0	0.021553	0	6	22										A	128368806	T	A	128368806	3	1	84	1	0	0	0	0	1	0	0	0	14530	1464	51	5	1729	5	SLC27A6	5	128368806	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	88991714	128368806	52546454	46	25322										
PCDHA8	56140	broad.mit.edu	37	chr5	140222221	140222221	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cgccttcgctgtgggccaccGccagcttgtctgtggaggtg	15	13	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:140222221G>A	uc003lhs.2	+	1	1315	c.1315G>A	c.(1315-1317)GCC>ACC	p.A439T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A439T	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	439	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGCCACCGCCAGCTTGTC	0.667													0	0	0	0.028581	0	17	108										A	140222221	G	A	140222221	3	1	84	1	0	0	0	0	1	0	0	0	11530	1087	38	2	1317	2	PCDHA8	5	140222221	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	11853415	140222221	40693039	47	25323										
PCDHA8	56140	broad.mit.edu	37	chr5	140222946	140222946	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	caggctccaaaagcgtcatcGaggcagtcggctggcgtttt	13	11	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:140222946G>A	uc003lhs.2	+	1	2040	c.2040G>A	c.(2038-2040)TCG>TCA	p.S680S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.S680S	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	680	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCGTCATCGAGGCAGTCGG	0.627													0	0	0	0.010729	0	12	99										A	140222946	G	A	140222946	2	1	84	1	0	0	0	0	0	0	0	1	11530	1045	37	1		1	PCDHA8	5	140222946	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	725	140222946	40692314	48	25324										
NSD1	64324	broad.mit.edu	37	chr5	176665484	176665484	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cacggcctgcccttgagtctGaggaattgctagttaaaacg	11	10	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:176665484G>C	uc003mfr.3	+	7	4306	c.4168G>C	c.(4168-4170)GAG>CAG	p.E1390Q	NSD1_uc003mft.3_Missense_Mutation_p.E1121Q|NSD1_uc003mfs.1_Missense_Mutation_p.E1287Q|NSD1_uc011dfx.1_Missense_Mutation_p.E1038Q	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1390					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTTGAGTCTGAGGAATTGCT	0.507			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.01892	0	23	71										C	176665484	G	C	176665484	3	2	84	1	0	0	0	0	1	0	0	0	10669	1291	45	1	4190	1	NSD1	5	176665484	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	36442538	176665484	4249776	49	25325										
RNF182	221687	broad.mit.edu	37	chr6	13977507	13977507	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aatgcctctacaagatcataGactttggggactccccacaa	7	12	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:13977507G>C	uc003nbe.2	+	3	575	c.157G>C	c.(157-159)GAC>CAC	p.D53H	RNF182_uc003nbf.2_Missense_Mutation_p.D53H|RNF182_uc003nbg.2_Missense_Mutation_p.D53H	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	53	RING-type.					cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CAAGATCATAGACTTTGGGGA	0.463													0	0	0	0.008291	0	11	164										C	13977507	G	C	13977507	3	2	84	1	0	0	0	0	1	0	0	0	13466	942	33	1	159	1	RNF182	6	13977507	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		13977507	157137560	50	25326										
ZNF311	282890	broad.mit.edu	37	chr6	28967310	28967310	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tccaacatcacatccttataGagatgcctttgagcgtaggt	8	10	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:28967310G>A	uc003nlu.2	-	5	777	c.264C>T	c.(262-264)CTC>CTT	p.L88L	ZNF311_uc011dlk.1_5'UTR|ZNF311_uc003nlv.2_5'UTR	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						CATCCTTATAGAGATGCCTTT	0.398													0	0	0	0.00308	0	7	88										A	28967310	G	A	28967310	2	1	84	1	0	0	0	0	0	0	0	1	17831	929	33	1		1	ZNF311	6	28967310	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	14989803	28967310	142147757	51	25327										
ELOVL5	60481	broad.mit.edu	37	chr6	53160459	53160459	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cctcgagggcctagcaatgcCttgaaataggtactaagtga	11	9	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:53160459C>G	uc003pbq.1	-	2	487	c.39G>C	c.(37-39)AAG>AAC	p.K13N	ELOVL5_uc003pbr.1_Missense_Mutation_p.K13N|ELOVL5_uc011dwx.1_Missense_Mutation_p.K13N|ELOVL5_uc003pbs.1_Missense_Mutation_p.K13N|ELOVL5_uc003pbu.2_Missense_Mutation_p.K13N|ELOVL5_uc011dwy.1_RNA	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	13					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					CTAGCAATGCCTTGAAATAGG	0.363													0	0	0	0.004672	0	3	11										G	53160459	C	G	53160459	3	3	84	1	0	0	0	0	1	0	0	0	5077	680	24	4	888	4	ELOVL5	6	53160459	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	24193149	53160459	117954608	52	25328										
UBE2J1	51465	broad.mit.edu	37	chr6	90053459	90053459	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttcaattctgccgcttctttCattaaacgtttaacagctaa	4	10	4	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:90053459C>T	uc010kcb.2	-	3	221	c.48G>A	c.(46-48)ATG>ATA	p.M16I	UBE2J1_uc003pnc.2_Missense_Mutation_p.M16I	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	16	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CCGCTTCTTTCATTAAACGTT	0.299													0	0	0	0.009096	0	4	32										T	90053459	C	T	90053459	3	4	84	1	0	0	0	0	1	0	0	0	16857	826	29	1	936	1	UBE2J1	6	90053459	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	36893000	90053459	81061608	53	25329										
AKD1	221264	broad.mit.edu	37	chr6	109867162	109867162	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	agcttgctcgttctcagaatCttcctcaaattcaggtccca	6	13	4	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:109867162C>G	uc003ptn.2	-	26	3210	c.3133G>C	c.(3133-3135)GAT>CAT	p.D1045H	AKD1_uc011eat.1_Missense_Mutation_p.D124H	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1045					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTCTCAGAATCTTCCTCAAAT	0.358													0	0	0	0.00308	0	8	88										G	109867162	C	G	109867162	3	3	84	1	0	0	0	0	1	0	0	0	460	913	32	1	2666	1	AKD1	6	109867162	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	19813703	109867162	61247905	54	25330										
PTPRK	5796	broad.mit.edu	37	chr6	128302401	128302401	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcacgctatactgcagtcttCagcttgtagtcgaggggtga	13	9	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:128302401C>T	uc003qbk.2	-	25	3935	c.3568G>A	c.(3568-3570)GAA>AAA	p.E1190K	PTPRK_uc003qbj.2_Missense_Mutation_p.E1191K|PTPRK_uc010kfc.2_Missense_Mutation_p.E1197K|PTPRK_uc011ebu.1_Missense_Mutation_p.E1213K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1190	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CTGCAGTCTTCAGCTTGTAGT	0.428													0	0	0	0.001984	0	5	25										T	128302401	C	T	128302401	3	4	84	1	0	0	0	0	1	0	0	0	12805	835	29	1	775	1	PTPRK	6	128302401	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	18435239	128302401	42812666	55	25331										
LAMA2	3908	broad.mit.edu	37	chr6	129475825	129475825	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gatggcttcttcagacccaaAggggtaaagtatgctttttc	10	8	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:129475825A>G	uc003qbn.2	+	8	1308	c.1203A>G	c.(1201-1203)AAA>AAG	p.K401K	LAMA2_uc003qbo.2_Silent_p.K401K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	401	Laminin EGF-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCAGACCCAAAGGGGTAAAGT	0.333													0	0	0	0.014758	0	5	50										G	129475825	A	G	129475825	2	3	84	1	0	0	0	0	0	0	0	1	8606	69	3	5		5	LAMA2	6	129475825	Silent	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08	1173424	129475825	41639242	56	25332										
HBS1L	10767	broad.mit.edu	37	chr6	135287557	135287557	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tctttatatagctcaagagcTattggtctttgtgtctgtag	9	6	4	1	rs1139174		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:135287557T>C	uc003qez.2	-	17	2160	c.1953A>G	c.(1951-1953)ATA>ATG	p.I651M	HBS1L_uc003qey.2_Missense_Mutation_p.I487M|HBS1L_uc011ecy.1_Missense_Mutation_p.I375M|HBS1L_uc011ecz.1_Missense_Mutation_p.I487M|HBS1L_uc011eda.1_Missense_Mutation_p.I609M	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Hsp70 subfamily B suppressor 1-like protein	651					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		GCTCAAGAGCTATTGGTCTTT	0.368													0	0	0	0.007291	0	27	85										C	135287557	T	C	135287557	3	2	84	1	0	0	0	0	1	0	0	0	6987	1512	53	5	109	5	HBS1L	6	135287557	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	5811732	135287557	35827510	57	25333										
TRIL	9865	broad.mit.edu	37	chr7	28996417	28996417	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggaagctgagggcgagggatCcgcgcaggatccattttgca	16	9	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:28996417C>T	uc003szt.2	-	3	1613	c.1246G>A	c.(1246-1248)GAT>AAT	p.D416N	uc003szu.1_5'Flank	NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	416	Extracellular (Potential).|LRRCT.				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0						GGCGAGGGATCCGCGCAGGAT	0.662													0	0	0	0.024245	0	15	42										T	28996417	C	T	28996417	3	4	84	1	0	0	0	0	1	0	0	0	16482	855	30	1	1193	1	TRIL	7	28996417	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08		28996417	130142246	58	25334										
MAGI2	9863	broad.mit.edu	37	chr7	79082591	79082591	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cctgccaatgacactctcatGgactttgctagtccagtggc	9	13	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:79082591G>A	uc003ugx.2	-	1	300	c.46C>T	c.(46-48)CAT>TAT	p.H16Y	MAGI2_uc003ugy.2_Missense_Mutation_p.H16Y|uc010lea.1_5'Flank	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	16						cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ACACTCTCATGGACTTTGCTA	0.592													0	0	0	0.024334	0	24	124										A	79082591	G	A	79082591	3	1	84	1	0	0	0	0	1	0	0	0	9191	1348	47	2	4409	2	MAGI2	7	79082591	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	50086174	79082591	80056072	59	25335										
AKAP9	10142	broad.mit.edu	37	chr7	91625086	91625086	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cacaatgcaaattagtttctTgcaagagaaaattaaagtat	6	5	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:91625086T>C	uc003ulg.2	+	7	1127	c.902T>C	c.(901-903)TTG>TCG	p.L301S	AKAP9_uc003uld.3_Missense_Mutation_p.L301S|AKAP9_uc003ule.2_Missense_Mutation_p.L313S|AKAP9_uc003ulf.2_Missense_Mutation_p.L301S	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	313	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATTAGTTTCTTGCAAGAGAAA	0.318			T	BRAF	papillary thyroid								0	0	0	0.00308	0	8	27										C	91625086	T	C	91625086	3	2	84	1	0	0	0	0	1	0	0	0	459	1821	63	5	928	5	AKAP9	7	91625086	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	12542495	91625086	67513577	60	25336										
ASB4	51666	broad.mit.edu	37	chr7	95125268	95125268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgttaagatcctctgtgatcGtggggcaaagctcaattgct	11	8	2	2	rs141186023		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:95125268G>A	uc011kij.1	+	2	386	c.386G>A	c.(385-387)CGT>CAT	p.R129H	ASB4_uc003unx.2_Missense_Mutation_p.R129H	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	129	ANK 2.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CTCTGTGATCGTGGGGCAAAG	0.458													0	0	0	0.016723	0	14	64										A	95125268	G	A	95125268	3	1	84	1	0	0	0	0	1	0	0	0	1025	1145	40	2	392	2	ASB4	7	95125268	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	3500182	95125268	64013395	61	25337										
BCAP29	55973	broad.mit.edu	37	chr7	107253835	107253835	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atgcagtcagagagactttcGaaagaatatgatcaactcct	8	8	2	4			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:107253835G>A	uc003vej.2	+	7	987	c.648G>A	c.(646-648)TCG>TCA	p.S216S	BCAP29_uc011kly.1_Silent_p.S122S|BCAP29_uc011klz.1_Silent_p.S216S|BCAP29_uc011kma.1_Silent_p.S216S	NM_018844	NP_061332	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein BAP29 isoform	216	Cytoplasmic (Potential).				apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				large_intestine(1)|ovary(1)	2						AGAGACTTTCGAAAGAATATG	0.323													0	0	0	0.010729	0	10	38										A	107253835	G	A	107253835	2	1	84	1	0	0	0	0	0	0	0	1	1346	1045	37	1		1	BCAP29	7	107253835	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	12128567	107253835	51884828	62	25338										
NCOA2	10499	broad.mit.edu	37	chr8	71126156	71126156	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	accttgttctttgatctgacGaatttgcttcacagtttctt	6	9	4	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr8:71126156G>A	uc003xyn.1	-	4	403	c.241C>T	c.(241-243)CGT>TGT	p.R81C		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	81	Basic motif.				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TTGATCTGACGAATTTGCTTC	0.343			T	RUNXBP2	AML								0	0	0	0.006214	0	10	21										A	71126156	G	A	71126156	3	1	84	1	0	0	0	0	1	0	0	0	10229	1058	37	1	4233	1	NCOA2	8	71126156	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		71126156	75237866	63	25339										
RPS6	6194	broad.mit.edu	37	chr9	19376294	19376294	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttgttactcaaaaaatcttaTttctgactggattcagactt	5	7	4	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:19376294T>C	uc003znv.1	-	6	789	c.747A>G	c.(745-747)AAA>AAG	p.K249K	RPS6_uc003znu.1_Silent_p.K218K	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	249					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		AAAAATCTTATTTCTGACTGG	0.383													0	0	0	0.004482	0	8	76										C	19376294	T	C	19376294	2	2	84	1	0	0	0	0	0	0	0	1	13649	1490	52	5		5	RPS6	9	19376294	Silent	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08		19376294	121837137	64	25340										
PGM5	5239	broad.mit.edu	37	chr9	71098912	71098912	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgtctacagcgtggcgaagaCggatagttttgaatacgtgg	14	6	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:71098912C>T	uc004agr.2	+	9	1656	c.1427C>T	c.(1426-1428)ACG>ATG	p.T476M		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	476					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						GTGGCGAAGACGGATAGTTTT	0.502													0	0	0	0.00499	0	17	68										T	71098912	C	T	71098912	3	4	84	1	0	0	0	0	1	0	0	0	11801	536	19	2	1461	2	PGM5	9	71098912	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	51722618	71098912	70114519	65	25341										
SUSD3	203328	broad.mit.edu	37	chr9	95841805	95841805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aggacttggagacggtgcagGccgcataccttggcctcaag	14	11	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:95841805G>A	uc004atb.2	+	4	514	c.478G>A	c.(478-480)GCC>ACC	p.A160T	SUSD3_uc004atc.2_Missense_Mutation_p.A147T	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3	160	Cytoplasmic (Potential).					integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						GACGGTGCAGGCCGCATACCT	0.612													0	0	0	0.016723	0	13	32										A	95841805	G	A	95841805	3	1	84	1	0	0	0	0	1	0	0	0	15406	1203	42	2	492	2	SUSD3	9	95841805	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	24742893	95841805	45371626	66	25342										
SMC2	10592	broad.mit.edu	37	chr9	106900437	106900437	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atgctgcgtactcatttcacAcattctcaggtaagaaccag	7	11	3	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:106900437A>G	uc004bbv.2	+	24	3696	c.3408A>G	c.(3406-3408)ACA>ACG	p.T1136T	SMC2_uc004bbw.2_Silent_p.T1136T|SMC2_uc011lvl.1_Silent_p.T1136T|SMC2_uc004bbx.2_Silent_p.T1136T|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1136					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						CTCATTTCACACATTCTCAGG	0.343													0	0	0	0.016522	0	22	39										G	106900437	A	G	106900437	2	3	84	1	0	0	0	0	0	0	0	1	14783	146	6	5		5	SMC2	9	106900437	Silent	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08	11058632	106900437	34312994	67	25343										
SNAPC4	6621	broad.mit.edu	37	chr9	139273423	139273423	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcgggggccccaggcccagaGagcggtacatttaagacggt	16	11	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:139273423G>A	uc004chh.2	-	21	2865	c.2856C>T	c.(2854-2856)CTC>CTT	p.L952L		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	952	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CAGGCCCAGAGAGCGGTACAT	0.657													0	0	0	0.014758	0	5	6										A	139273423	G	A	139273423	2	1	84	1	0	0	0	0	0	0	0	1	14837	929	33	1		1	SNAPC4	9	139273423	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	32372986	139273423	1940008	68	25344										
MAMDC4	158056	broad.mit.edu	37	chr9	139752992	139752992	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tggaccacaccctgggcacaGaggcaggtacgtgcccactg	13	14	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:139752992G>A	uc004cjs.2	+	22	2865	c.2815G>A	c.(2815-2817)GAG>AAG	p.E939K	MAMDC4_uc011mej.1_Missense_Mutation_p.E276K	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1018	Extracellular (Potential).|MAM 6.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCTGGGCACAGAGGCAGGTAC	0.706													0	0	0	0.004672	0	3	12										A	139752992	G	A	139752992	3	1	84	1	0	0	0	0	1	0	0	0	9204	943	33	1	2901	1	MAMDC4	9	139752992	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	479569	139752992	1460439	69	25345										
MAMDC4	158056	broad.mit.edu	37	chr9	139754441	139754441	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gggggacggcgctggctgcaGaagaaggggagctgcccctt	19	10	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:139754441G>C	uc004cjs.2	+	26	3347	c.3297G>C	c.(3295-3297)CAG>CAC	p.Q1099H	MAMDC4_uc011mej.1_Missense_Mutation_p.Q436H	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1178	Cytoplasmic (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GCTGGCTGCAGAAGAAGGGGA	0.632													0	0	0	0.014758	0	5	14										C	139754441	G	C	139754441	3	2	84	1	0	0	0	0	1	0	0	0	9204	933	33	1	3399	1	MAMDC4	9	139754441	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	1449	139754441	1458990	70	25346										
ADARB2	105	broad.mit.edu	37	chr10	1405298	1405298	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tcgaacagctcctgcagtgcGgcctgcgcggcctgaccccg	13	17	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:1405298G>A	uc009xhq.2	-	3	1376	c.1002C>T	c.(1000-1002)GCC>GCT	p.A334A		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	334	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CCTGCAGTGCGGCCTGCGCGG	0.746													0	0	0	0.009096	0	3	9										A	1405298	G	A	1405298	2	1	84	1	0	0	0	0	0	0	0	1	283	1103	39	2		2	ADARB2	10	1405298	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		1405298	134129449	71	25347										
SVIL	6840	broad.mit.edu	37	chr10	29821479	29821479	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gttcaggtctcctgcaggcgTtggcagatgccaggaacgca	14	11	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:29821479T>A	uc001iut.1	-	8	2570	c.1817A>T	c.(1816-1818)AAC>ATC	p.N606I	SVIL_uc001iuu.1_Intron|SVIL_uc009xld.1_Missense_Mutation_p.N606I	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	606					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CCTGCAGGCGTTGGCAGATGC	0.577													0	0	0	0.00308	0	8	27										A	29821479	T	A	29821479	3	1	84	1	0	0	0	0	1	0	0	0	15418	1725	60	5	4951	5	SVIL	10	29821479	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	28416181	29821479	105713268	72	25348										
ATRNL1	26033	broad.mit.edu	37	chr10	117228809	117228809	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	attacattctatgtgtacgtCagcaacttttcctggcctat	6	10	2	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:117228809C>T	uc001lcg.2	+	24	4010	c.3624C>T	c.(3622-3624)GTC>GTT	p.V1208V	ATRNL1_uc010qsm.1_Silent_p.V337V|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1208	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ATGTGTACGTCAGCAACTTTT	0.294													0	0	0	0.004482	0	9	67										T	117228809	C	T	117228809	2	4	84	1	0	0	0	0	0	0	0	1	1207	813	29	1		1	ATRNL1	10	117228809	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	87407330	117228809	18305938	73	25349										
TACC2	10579	broad.mit.edu	37	chr10	123844356	123844356	+	Frame_Shift_Del	DEL	C	C	-													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttcatgctggggtgccacatCccccccagggggagaacttg							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:123844356delC	uc001lfv.2	+	4	2701	c.2341delC	c.(2341-2343)CCCfs	p.P781fs	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Frame_Shift_Del_p.P781fs|TACC2_uc010qtv.1_Frame_Shift_Del_p.P781fs	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	781						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGTGCCACATCCCCCCCAGGG	0.642																		10	93	---	---								-	123844356	C	-	123844356	7	5	84	1	0	1	0	1	0	0	0	0	15499	855	30	0	2351	0	TACC2	10	123844356	Frame_Shift_Del	DEL	C	TCGA-FD-A3SP-01A-31D-A22Z-08	6615547	123844356	11690391	74	25350										
LDHC	3948	broad.mit.edu	37	chr11	18460094	18460094	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtgcccttatggagtggggtGaatgttgctggtgttgctct	16	6	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:18460094G>C	uc001mon.3	+	6	724	c.612G>C	c.(610-612)GTG>GTC	p.V204V	LDHC_uc001mom.3_Silent_p.V204V|LDHC_uc009yhp.2_Silent_p.V204V|LDHC_uc001moo.3_Silent_p.V88V|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Intron	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	204					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	GGAGTGGGGTGAATGTTGCTG	0.373													0	0	0	0.013537	0	12	74										C	18460094	G	C	18460094	2	2	84	1	0	0	0	0	0	0	0	1	8702	1277	45	1		1	LDHC	11	18460094	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		18460094	116546422	75	25351										
MUC15	143662	broad.mit.edu	37	chr11	26587103	26587103	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtggaaatggtagatgtgggTtttagactgcccaaagaatg	14	4	0	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:26587103T>C	uc001mqx.2	-	2	569	c.303A>G	c.(301-303)AAA>AAG	p.K101K	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Silent_p.K128K|MUC15_uc001mqy.2_Silent_p.K128K	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	101	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TAGATGTGGGTTTTAGACTGC	0.453													0	0	0	0.008871	0	20	89										C	26587103	T	C	26587103	2	2	84	1	0	0	0	0	0	0	0	1	9972	1722	60	5		5	MUC15	11	26587103	Silent	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	8127009	26587103	108419413	76	25352										
CKAP5	9793	broad.mit.edu	37	chr11	46786765	46786765	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccggatttgtcttcatcctcCtttaagctggttttgcttgg	9	10	2	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:46786765C>T	uc001ndi.1	-	28	3563	c.3453G>A	c.(3451-3453)AAG>AAA	p.K1151K	CKAP5_uc009ylg.1_Silent_p.K1037K|CKAP5_uc001ndj.1_Silent_p.K1151K|CKAP5_uc001ndh.1_Silent_p.K80K|SNORD67_uc001ndk.2_5'Flank	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1151					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CTTCATCCTCCTTTAAGCTGG	0.398													0	0	0	0.024334	0	27	81										T	46786765	C	T	46786765	2	4	84	1	0	0	0	0	0	0	0	1	3445	680	24	2		2	CKAP5	11	46786765	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	20199662	46786765	88219751	77	25353										
OMP	4975	broad.mit.edu	37	chr11	76814355	76814355	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcccgccaacctcaaggcctCcgtggtttttaaccagctct	8	16	2	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:76814355C>T	uc010rsk.1	+	1	470	c.470C>T	c.(469-471)TCC>TTC	p.S157F	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	157					sensory perception of smell|synaptic transmission						0						CTCAAGGCCTCCGTGGTTTTT	0.602													0	0	0	0.013537	0	11	76										T	76814355	C	T	76814355	3	4	84	1	0	0	0	0	1	0	0	0	10867	855	30	1	472	1	OMP	11	76814355	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	30027590	76814355	58192161	78	25354										
NOX4	50507	broad.mit.edu	37	chr11	89133385	89133385	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgctgaccactgactcacctGaccaggtcttgctttaaaat	7	12	2	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:89133385G>A	uc001pct.2	-	10	1248	c.1009C>T	c.(1009-1011)CAG>TAG	p.Q337*	NOX4_uc009yvr.2_Nonsense_Mutation_p.Q312*|NOX4_uc001pcu.2_Nonsense_Mutation_p.Q263*|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Nonsense_Mutation_p.Q337*|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Nonsense_Mutation_p.Q171*|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Nonsense_Mutation_p.Q313*|NOX4_uc009yvq.2_Nonsense_Mutation_p.Q313*	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	337	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TGACTCACCTGACCAGGTCTT	0.373													0	0	0	0.006214	0	9	98										A	89133385	G	A	89133385	4	1	84	1	0	0	0	0	0	1	0	0	10558	1299	45	1	763	1	NOX4	11	89133385	Nonsense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	12319030	89133385	45873131	79	25355										
DSCAML1	57453	broad.mit.edu	37	chr11	117303215	117303215	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cacagggatggtggccttgtCatctcctggggaaagaagga	15	8	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:117303215C>T	uc001prh.1	-	30	5214	c.5212G>A	c.(5212-5214)GAC>AAC	p.D1738N		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1678	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTGGCCTTGTCATCTCCTGGG	0.463													0	0	0	0.001984	0	7	72										T	117303215	C	T	117303215	3	4	84	1	0	0	0	0	1	0	0	0	4769	826	29	1	1145	1	DSCAML1	11	117303215	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	28169830	117303215	17703301	80	25356										
MFRP	83552	broad.mit.edu	37	chr11	119216184	119216184	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccaagcgatcaaaaaggcaaGaggccacactctctatgctg	9	12	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:119216184G>T	uc001pwj.2	-	5	747	c.587C>A	c.(586-588)TCT>TAT	p.S196Y	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.S196Y	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		AAAAAGGCAAGAGGCCACACT	0.582													1	0	3.59834e-05	0.021553	3.66416e-05	4	45										T	119216184	G	T	119216184	3	4	84	1	0	0	0	0	1	0	0	0	9526	942	33	3	1188	3	MFRP	11	119216184	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	1912969	119216184	15790332	81	25357			1	114		3	3	360	G		1.408277e-06
MFRP	83552	broad.mit.edu	37	chr11	119216325	119216325	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgaagaagccccttgggccaGagaggaggcctccacaggct	14	12	0	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:119216325G>C	uc001pwj.2	-	5	606	c.446C>G	c.(445-447)TCT>TGT	p.S149C	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.S149C	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCTTGGGCCAGAGAGGAGGCC	0.567													0	0	0	0.001984	0	7	29										C	119216325	G	C	119216325	3	2	84	1	0	0	0	0	1	0	0	0	9526	942	33	1	1329	1	MFRP	11	119216325	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	141	119216325	15790191	82	25358			1	114		3	3	360	G		1.408277e-06
MFRP	83552	broad.mit.edu	37	chr11	119216543	119216543	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tttaggggtcccagctgcctGagaggtggtgatggtggggg	20	6	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:119216543G>C	uc001pwj.2	-	4	527	c.367C>G	c.(367-369)CAG>GAG	p.Q123E	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.Q123E	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	44	Collagen-like.					collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCAGCTGCCTGAGAggtggtg	0.552													0	0	0	0.008291	0	10	60										C	119216543	G	C	119216543	3	2	84	1	0	0	0	0	1	0	0	0	9526	1299	45	1	1412	1	MFRP	11	119216543	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	218	119216543	15789973	83	25359			1	114		3	3	360	G		1.408277e-06
VWF	7450	broad.mit.edu	37	chr12	6078422	6078422	+	Nonsense_Mutation	SNP	G	G	A													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgaggtcttacagctcagctGaaagcccgaggggcagacag							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:6078422G>A	uc001qnn.1	-	45	7934	c.7684C>T	c.(7684-7686)CAG>TAG	p.Q2562*	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2562					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CAGCTCAGCTGAAAGCCCGAG	0.592													0	0	0	0.001984	0	7	23										A	6078422	G	A	6078422	4	1	84	1	0	0	0	0	0	1	0	0	17243	1299	45	1	789	1	VWF	12	6078422	Nonsense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		6078422	127773473	84	25360	127	2								
VWF	7450	broad.mit.edu	37	chr12	6078430	6078430	+	Missense_Mutation	SNP	G	G	A													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tacagctcagctgaaagcccGaggggcagacagggacctcc							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:6078430G>A	uc001qnn.1	-	45	7926	c.7676C>T	c.(7675-7677)TCG>TTG	p.S2559L	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2559					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CTGAAAGCCCGAGGGGCAGAC	0.592													0	0	0	0.006214	0	9	25										A	6078430	G	A	6078430	3	1	84	1	0	0	0	0	1	0	0	0	17243	1059	37	1	797	1	VWF	12	6078430	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	8	6078430	127773465	85	25361	127	2								
STRAP	11171	broad.mit.edu	37	chr12	16052918	16052918	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tctatgccagtggttcagaaGatggaacattgagactatgg	12	6	2	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:16052918G>A	uc001rdc.3	+	8	1210	c.856G>A	c.(856-858)GAT>AAT	p.D286N	STRAP_uc010shw.1_Missense_Mutation_p.D299N|STRAP_uc001rdd.3_Missense_Mutation_p.D192N	NM_007178	NP_009109	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated	286	WD 7.				mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			skin(1)	1		Hepatocellular(102;0.121)				TGGTTCAGAAGATGGAACATT	0.388													0	0	0	0.008871	0	18	82										A	16052918	G	A	16052918	3	1	84	1	0	0	0	0	1	0	0	0	15325	942	33	1	886	1	STRAP	12	16052918	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	9974488	16052918	117798977	86	25362										
PRICKLE1	144165	broad.mit.edu	37	chr12	42853914	42853914	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtggcatgggcgtactgtccGtagagatcagcattctggat	14	8	2	1	rs137985321	byFrequency	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:42853914G>T	uc010skv.1	-	8	2480	c.2193C>A	c.(2191-2193)TAC>TAA	p.Y731*	PRICKLE1_uc001rnl.2_Nonsense_Mutation_p.Y731*|PRICKLE1_uc010skw.1_Nonsense_Mutation_p.Y731*|PRICKLE1_uc001rnm.2_Nonsense_Mutation_p.Y731*|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	731					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CGTACTGTCCGTAGAGATCAG	0.493													1	0	1.5739e-10	0.028581	1.70676e-10	17	83										T	42853914	G	T	42853914	4	4	84	1	0	0	0	0	0	1	0	0	12486	1140	40	4	306	4	PRICKLE1	12	42853914	Nonsense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	26800996	42853914	90997981	87	25363										
MLL2	8085	broad.mit.edu	37	chr12	49444391	49444391	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gatcataggggggacaggctCagggtcagtgcagttagctt	16	7	3	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:49444391C>A	uc001rta.3	-	11	2980	c.2980G>T	c.(2980-2982)GAG>TAG	p.E994*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	994	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGACAGGCTCAGGGTCAGTG	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	5.9392e-07	0.021553	6.19904e-07	6	35										A	49444391	C	A	49444391	4	1	84	1	0	0	0	0	0	1	0	0	9621	835	29	3	13809	3	MLL2	12	49444391	Nonsense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	6590477	49444391	84407504	88	25364										
MLL2	8085	broad.mit.edu	37	chr12	49445170	49445170	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gggggacaggtgtggctcctCagcctgcggagataggtgtg	19	8	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:49445170C>T	uc001rta.3	-	10	2296	c.2296G>A	c.(2296-2298)GAG>AAG	p.E766K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	766	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTGGCTCCTCAGCCTGCGGA	0.697			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.014758	0	5	39										T	49445170	C	T	49445170	3	4	84	1	0	0	0	0	1	0	0	0	9621	835	29	1	14497	1	MLL2	12	49445170	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	779	49445170	84406725	89	25365										
ITGA7	3679	broad.mit.edu	37	chr12	56086673	56086673	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcagaggacactggccaccaGgacatgctgggctcctgccg	14	14	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:56086673G>A	uc001shh.2	-	21	3031	c.2811C>T	c.(2809-2811)TCC>TCT	p.S937S	ITGA7_uc001shg.2_Silent_p.S933S|ITGA7_uc010sps.1_Silent_p.S840S|ITGA7_uc009znw.2_Silent_p.S180S|ITGA7_uc009znx.2_Silent_p.S814S	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	977	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CTGGCCACCAGGACATGCTGG	0.642													0	0	0	0.009096	0	4	24										A	56086673	G	A	56086673	2	1	84	1	0	0	0	0	0	0	0	1	7881	987	35	2		2	ITGA7	12	56086673	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	6641503	56086673	77765222	90	25366										
TRHDE	29953	broad.mit.edu	37	chr12	73046848	73046848	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgctggatcaagatgcaattGatgtcataatccatgtagct	9	7	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:73046848G>A	uc001sxa.2	+	17	2791	c.2761G>A	c.(2761-2763)GAT>AAT	p.D921N		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	921	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AGATGCAATTGATGTCATAAT	0.353													0	0	0	0.021553	0	6	59										A	73046848	G	A	73046848	3	1	84	1	0	0	0	0	1	0	0	0	16476	1290	45	1	2827	1	TRHDE	12	73046848	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	16960175	73046848	60805047	91	25367										
C12orf74	338809	broad.mit.edu	37	chr12	93100779	93100779	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcagctgactcactggagccCcaaacccggcccactgacaa	9	17	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:93100779C>T	uc001tch.1	+	2	602	c.372C>T	c.(370-372)CCC>CCT	p.P124P	C12orf74_uc001tci.2_Silent_p.P124P	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	124											0						CACTGGAGCCCCAAACCCGGC	0.557													0	0	0	0.001984	0	6	79										T	93100779	C	T	93100779	2	4	84	1	0	0	0	0	0	0	0	1	1714	610	22	2		2	C12orf74	12	93100779	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	20053931	93100779	40751116	92	25368										
EEA1	8411	broad.mit.edu	37	chr12	93244925	93244925	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgactgcaattttttgcattCatctttgagtttttcagatt	6	6	3	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:93244925C>T	uc001tck.2	-	9	1025	c.760G>A	c.(760-762)GAA>AAA	p.E254K		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	254	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TTTTTGCATTCATCTTTGAGT	0.363													0	0	0	0.004482	0	8	48										T	93244925	C	T	93244925	3	4	84	1	0	0	0	0	1	0	0	0	4921	835	29	1	3559	1	EEA1	12	93244925	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	144146	93244925	40606970	93	25369										
PAN3	255967	broad.mit.edu	37	chr13	28794473	28794473	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccttctctcaagttttctctCacccatccatgggaagccct	5	16	4	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:28794473C>T	uc001urz.2	+	5	528	c.520C>T	c.(520-522)CAC>TAC	p.H174Y	PAN3_uc010tdo.1_Missense_Mutation_p.H320Y|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Missense_Mutation_p.H120Y	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	320	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		AGTTTTCTCTCACCCATCCAT	0.458													0	0	0	0.017118	0	33	147										T	28794473	C	T	28794473	3	4	84	1	0	0	0	0	1	0	0	0	11415	826	29	1	980	1	PAN3	13	28794473	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08		28794473	86375405	94	25370										
TRPC4	7223	broad.mit.edu	37	chr13	38213252	38213252	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcaacgtatcgcttcaccagGttcctcataacttcctgagg	8	13	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:38213252G>T	uc001uws.2	-	10	2371	c.2136C>A	c.(2134-2136)AAC>AAA	p.N712K	TRPC4_uc010abv.2_Missense_Mutation_p.N292K|TRPC4_uc001uwt.2_Missense_Mutation_p.N712K|TRPC4_uc010tey.1_Missense_Mutation_p.N712K|TRPC4_uc010abw.2_Missense_Mutation_p.N539K|TRPC4_uc010abx.2_Missense_Mutation_p.N717K|TRPC4_uc010aby.2_Missense_Mutation_p.N647K	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	712	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GCTTCACCAGGTTCCTCATAA	0.398													1	0	2.94398e-08	0.007413	3.1315e-08	18	174										T	38213252	G	T	38213252	3	4	84	1	0	0	0	0	1	0	0	0	16577	1252	44	4	805	4	TRPC4	13	38213252	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	9418779	38213252	76956626	95	25371										
SLITRK6	84189	broad.mit.edu	37	chr13	86368575	86368575	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gaccaaaggatggacttctaTagacatgaaccatggggctc	11	9	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:86368575T>C	uc001vll.1	-	2	2528	c.2069A>G	c.(2068-2070)TAT>TGT	p.Y690C	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	690	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGGACTTCTATAGACATGAAC	0.443													0	0	0	0.01441	0	50	255										C	86368575	T	C	86368575	3	2	84	1	0	0	0	0	1	0	0	0	14747	1406	49	5	460	5	SLITRK6	13	86368575	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	48155323	86368575	28801303	96	25372										
TPP2	7174	broad.mit.edu	37	chr13	103326727	103326727	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttcacacccaggctcaagacGgagccatttccactgatgca	8	14	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:103326727G>A	uc001vpi.3	+	27	3530	c.3427G>A	c.(3427-3429)GGA>AGA	p.G1143R		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	1143					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGCTCAAGACGGAGCCATTTC	0.473													0	0	0	0.028581	0	17	62										A	103326727	G	A	103326727	3	1	84	1	0	0	0	0	1	0	0	0	16409	1117	39	2	3533	2	TPP2	13	103326727	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	16958152	103326727	11843151	97	25373										
LIG4	3981	broad.mit.edu	37	chr13	108860901	108860901	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttaaatcaaatactggttttCttcttgtaattcacacttgt	4	7	4	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:108860901C>T	uc001vqn.2	-	2	2989	c.2716G>A	c.(2716-2718)GAA>AAA	p.E906K	LIG4_uc001vqo.2_Missense_Mutation_p.E906K|LIG4_uc010agg.1_Missense_Mutation_p.E839K|LIG4_uc010agf.2_Missense_Mutation_p.E906K|LIG4_uc001vqp.2_Missense_Mutation_p.E906K	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	906	BRCT 2.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TACTGGTTTTCTTCTTGTAAT	0.333								NHEJ					0	0	0	0.010729	0	11	25										T	108860901	C	T	108860901	3	4	84	1	0	0	0	0	1	0	0	0	8783	922	32	1	23	1	LIG4	13	108860901	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	5534174	108860901	6308977	98	25374										
CPNE6	9362	broad.mit.edu	37	chr14	24546221	24546221	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cagagcaccggccaagccacGgtaggaagacatggcgggca	15	12	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr14:24546221G>A	uc001wll.2	+	14	1398	c.1299G>A	c.(1297-1299)ACG>ACA	p.T433T	CPNE6_uc010tnv.1_Silent_p.T488T|CPNE6_uc001wlm.2_Silent_p.T258T|CPNE6_uc001wln.2_Silent_p.T101T	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	433	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		GCCAAGCCACGGTAGGAAGAC	0.637													0	0	0	0.014758	0	5	12										A	24546221	G	A	24546221	2	1	84	1	0	0	0	0	0	0	0	1	3816	1130	39	2		2	CPNE6	14	24546221	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		24546221	82803319	99	25375										
BMP4	652	broad.mit.edu	37	chr14	54417548	54417548	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttctcagggatgctgctgagGttaaagaggaaacgaaaagc	13	6	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr14:54417548G>A	uc001xal.3	-	3	616	c.429C>T	c.(427-429)AAC>AAT	p.N143N	BMP4_uc010aoh.2_Silent_p.N143N|BMP4_uc001xao.3_Silent_p.N143N|BMP4_uc001xan.3_Silent_p.N143N	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	143					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						TGCTGCTGAGGTTAAAGAGGA	0.527													0	0	0	0.00499	0	16	43										A	54417548	G	A	54417548	2	1	84	1	0	0	0	0	0	0	0	1	1462	1252	44	2		2	BMP4	14	54417548	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	29871327	54417548	52931992	100	25376										
CYFIP1	23191	broad.mit.edu	37	chr15	22929892	22929892	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gaacgaccactcagcgtacaAgaggtgagcacccacctcgc	10	15	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:22929892A>G	uc001yus.2	+	6	670	c.566A>G	c.(565-567)AAG>AGG	p.K189R	CYFIP1_uc001yut.2_Missense_Mutation_p.K189R|CYFIP1_uc010aya.1_Missense_Mutation_p.K217R	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	189					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TCAGCGTACAAGAGGTGAGCA	0.567													0	0	0	0.006122	0	8	26										G	22929892	A	G	22929892	3	3	84	1	0	0	0	0	1	0	0	0	4137	72	3	5	584	5	CYFIP1	15	22929892	Missense_Mutation	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08		22929892	79601500	101	25377										
MAP1A	4130	broad.mit.edu	37	chr15	43817292	43817292	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gaagagagtcccagcaaggaGacctccctggatgtctcttc	11	12	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:43817292G>C	uc001zrt.2	+	4	4088	c.3621G>C	c.(3619-3621)GAG>GAC	p.E1207D		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1207						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCAGCAAGGAGACCTCCCTGG	0.522													0	0	0	0.016723	0	13	84										C	43817292	G	C	43817292	3	2	84	1	0	0	0	0	1	0	0	0	9227	933	33	1	3623	1	MAP1A	15	43817292	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	20887400	43817292	58714100	102	25378										
SECISBP2L	9728	broad.mit.edu	37	chr15	49329879	49329879	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	accagaaacacttccattatCatttgggagagccataggga	9	9	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:49329879C>T	uc001zxe.1	-	2	246	c.112G>A	c.(112-114)GAT>AAT	p.D38N	SECISBP2L_uc001zxd.1_Missense_Mutation_p.D38N|SECISBP2L_uc010bep.1_5'UTR|SECISBP2L_uc010beq.1_Missense_Mutation_p.D38N	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	38										breast(1)|skin(1)	2						CTTCCATTATCATTTGGGAGA	0.423													0	0	0	0.014758	0	5	32										T	49329879	C	T	49329879	3	4	84	1	0	0	0	0	1	0	0	0	14007	826	29	1	3122	1	SECISBP2L	15	49329879	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	5512587	49329879	53201513	103	25379										
TRPM7	54822	broad.mit.edu	37	chr15	50866552	50866552	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tagcatgatctcttccagagTattagttggaataatctcat	7	7	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:50866552T>A	uc001zyt.3	-	36	5491	c.5227A>T	c.(5227-5229)ACT>TCT	p.T1743S	TRPM7_uc001zyr.2_Missense_Mutation_p.T180S	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1743	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCTTCCAGAGTATTAGTTGGA	0.358													0	0	0	0.001984	0	6	88										A	50866552	T	A	50866552	3	1	84	1	0	0	0	0	1	0	0	0	16588	1638	57	5	386	5	TRPM7	15	50866552	Missense_Mutation	SNP	T	TCGA-FD-A3SP-01A-31D-A22Z-08	1536673	50866552	51664840	104	25380										
LARP6	55323	broad.mit.edu	37	chr15	71125360	71125360	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aacagtgggacgggggtggtCctcctcaccttccggtggtc	15	12	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:71125360C>G	uc002ass.2	-	3	578	c.507G>C	c.(505-507)AGG>AGC	p.R169S		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	169	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						CGGGGGTGGTCCTCCTCACCT	0.547													0	0	0	0.021553	0	6	42										G	71125360	C	G	71125360	3	3	84	1	0	0	0	0	1	0	0	0	8632	854	30	1	972	1	LARP6	15	71125360	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	20258808	71125360	31406032	105	25381										
CRABP1	1381	broad.mit.edu	37	chr15	78640302	78640302	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atgacgtggtctgcaccagaAtttatgtccgagagtgaagg	13	7	1	4			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:78640302A>G	uc002bdp.2	+	4	502	c.397A>G	c.(397-399)ATT>GTT	p.I133V		NM_004378	NP_004369	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	133	Retinoic acid binding (By similarity).				multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity				0					Alitretinoin(DB00523)|Etretinate(DB00926)	CTGCACCAGAATTTATGTCCG	0.493													0	0	0	0.010729	0	10	63										G	78640302	A	G	78640302	3	3	84	1	0	0	0	0	1	0	0	0	3843	101	4	5	411	5	CRABP1	15	78640302	Missense_Mutation	SNP	A	TCGA-FD-A3SP-01A-31D-A22Z-08	7514942	78640302	23891090	106	25382										
CREBBP	1387	broad.mit.edu	37	chr16	3788618	3788618	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctcatggtaaacggctgtgcGgaggcaacgtggccggaaga	16	9	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:3788618G>A	uc002cvv.2	-	26	4540	c.4336C>T	c.(4336-4338)CGC>TGC	p.R1446C	CREBBP_uc002cvw.2_Missense_Mutation_p.R1408C	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1446	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R1446H(3)|p.R1446L(2)|p.R1446C(2)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACGGCTGTGCGGAGGCAACGT	0.413			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.021553	0	5	21										A	3788618	G	A	3788618	3	1	84	1	0	0	0	0	1	0	0	0	3861	1116	39	2	3016	2	CREBBP	16	3788618	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		3788618	86566135	107	25383										
ADCY9	115	broad.mit.edu	37	chr16	4016470	4016470	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggctgccgtcctgggcctgcGcggtgttcagccctgacgcc	15	16	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:4016470G>A	uc002cvx.2	-	11	3907	c.3368C>T	c.(3367-3369)GCG>GTG	p.A1123V		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1123	Guanylate cyclase 2.|Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CTGGGCCTGCGCGGTGTTCAG	0.602													0	0	0	0.004482	0	8	81										A	4016470	G	A	4016470	3	1	84	1	0	0	0	0	1	0	0	0	301	1087	38	2	697	2	ADCY9	16	4016470	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	227852	4016470	86338283	108	25384										
EMP2	2013	broad.mit.edu	37	chr16	10631801	10631801	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttacatgacattagctggatGatggaggttaggacaaacct	11	6	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:10631801G>A	uc002czx.2	-	4	494	c.300C>T	c.(298-300)ATC>ATT	p.I100I		NM_001424	NP_001415	P54851	EMP2_HUMAN	epithelial membrane protein 2	100	Helical; (Potential).				cell proliferation	integral to membrane					0						TTAGCTGGATGATGGAGGTTA	0.542													0	0	0	0.012319	0	22	79										A	10631801	G	A	10631801	2	1	84	1	0	0	0	0	0	0	0	1	5102	1280	45	1		1	EMP2	16	10631801	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	6615331	10631801	79722952	109	25385										
ACSM5	54988	broad.mit.edu	37	chr16	20448621	20448621	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggcctgttgaagtggaaagtGccctggcagagcatcctgct	14	10	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:20448621G>T	uc002dhe.2	+	12	1615	c.1468G>T	c.(1468-1470)GCC>TCC	p.A490S		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	490					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						AGTGGAAAGTGCCCTGGCAGA	0.567													1	0	0.00829132	0.008291	0.00834127	10	63										T	20448621	G	T	20448621	3	4	84	1	0	0	0	0	1	0	0	0	187	1319	46	4	1510	4	ACSM5	16	20448621	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	9816820	20448621	69906132	110	25386										
DNAH3	55567	broad.mit.edu	37	chr16	20952843	20952844	+	Frame_Shift_Ins	INS	-	-	G													0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aagcttggagagaatgtcttINSgtgccaactcctcaaccact							TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:20952843_20952844insG	uc010vbe.1	-	59	11533_11534	c.11533_11534insC	c.(11533-11535)CAAfs	p.Q3845fs	DNAH3_uc010vbd.1_Frame_Shift_Ins_p.Q1280fs	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3845					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GAGAATGTCTTGTGCCAACTCC	0.475																		36	124	---	---								G	20952844	-	G	20952843	7	5	84	1	0	1	1	0	0	0	0	0	4603	1812	63	0	831	0	DNAH3	16	20952843	Frame_Shift_Ins	INS	-	TCGA-FD-A3SP-01A-31D-A22Z-08	504222	20952843	69401910	111	25387										
SALL1	6299	broad.mit.edu	37	chr16	51174110	51174110	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtccaggagtcccccaaaagGaaacttggccttgaactgct	10	12	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:51174110G>C	uc010vgs.1	-	2	2054	c.2023C>G	c.(2023-2025)CCT>GCT	p.P675A	SALL1_uc010vgr.1_Missense_Mutation_p.P578A|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	675					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCCCCAAAAGGAAACTTGGCC	0.582													0	0	0	0.010729	0	11	80										C	51174110	G	C	51174110	3	2	84	1	0	0	0	0	1	0	0	0	13810	1174	41	1	1959	1	SALL1	16	51174110	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	30221267	51174110	39180643	112	25388										
CX3CL1	6376	broad.mit.edu	37	chr16	57416922	57416922	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccggagctgtggtagtaattCatatgtcctggtgcccgtgt	13	9	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:57416922C>T	uc002eli.2	+	3	1239	c.1172C>T	c.(1171-1173)TCA>TTA	p.S391L		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	391	Cytoplasmic (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GGTAGTAATTCATATGTCCTG	0.577													0	0	0	0.013537	0	11	84										T	57416922	C	T	57416922	3	4	84	1	0	0	0	0	1	0	0	0	4074	838	29	1	1182	1	CX3CL1	16	57416922	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	6242812	57416922	32937831	113	25389										
RLTPR	146206	broad.mit.edu	37	chr16	67679643	67679643	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ccaggcactgctacgatggaGagcctacctgctgcacacca	10	15	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:67679643G>C	uc002etn.2	+	3	269	c.149G>C	c.(148-150)AGA>ACA	p.R50T	RLTPR_uc010cel.1_Missense_Mutation_p.R50T|RLTPR_uc010vjr.1_Missense_Mutation_p.R50T	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	50										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CTACGATGGAGAGCCTACCTG	0.667													0	0	0	0.006214	0	10	77										C	67679643	G	C	67679643	3	2	84	1	0	0	0	0	1	0	0	0	13394	942	33	1	159	1	RLTPR	16	67679643	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	10262721	67679643	22675110	114	25390										
COG4	25839	broad.mit.edu	37	chr16	70516007	70516007	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctgctcaccttgaactctgcCatttgctgctccaggttaag	8	13	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:70516007C>G	uc002ezc.2	-	16	2003	c.1992G>C	c.(1990-1992)ATG>ATC	p.M664I	COG4_uc002eza.2_Missense_Mutation_p.M1I|COG4_uc002ezb.2_Missense_Mutation_p.M120I|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.M643I|COG4_uc002eze.2_Missense_Mutation_p.M358I	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	660	D domain.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TGAACTCTGCCATTTGCTGCT	0.532													0	0	0	0.008291	0	10	55										G	70516007	C	G	70516007	3	3	84	1	0	0	0	0	1	0	0	0	3660	594	21	4	393	4	COG4	16	70516007	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	2836364	70516007	19838746	115	25391										
TP53	7157	broad.mit.edu	37	chr17	7576886	7576886	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tattctccatccagtggtttCttctttggctggggagagga	12	8	3	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7576886C>T	uc002gim.2	-	9	1154	c.960G>A	c.(958-960)AAG>AAA	p.K320K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Silent_p.K320K|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Silent_p.K188K|TP53_uc010cng.1_Silent_p.K188K|TP53_uc002gii.1_Silent_p.K188K|TP53_uc010cnh.1_Silent_p.K320K|TP53_uc010cni.1_Silent_p.K320K|TP53_uc002gij.2_Silent_p.K320K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	320	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		K -> N (in sporadic cancers; somatic mutation).	K->A: Loss of nuclear localization; when associated with A-319 and A-321.	activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.K320N(3)|p.K320fs*26(2)|p.K320*(2)|p.P318fs*21(1)|p.S315fs*22(1)|p.?(1)|p.K320fs*25(1)|p.L308fs*15(1)|p.K320fs*18(1)|p.K320K(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCAGTGGTTTCTTCTTTGGCT	0.458		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.021523	0	26	41										T	7576886	C	T	7576886	2	4	84	1	0	0	0	0	0	0	0	1	16378	912	32	1		1	TP53	17	7576886	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08		7576886	73618324	116	25392										
TP53	7157	broad.mit.edu	37	chr17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cttcctctgtgcgccggtctCtcccaggacaggcacaaaca	9	16	2	0	rs121912660		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.013537	0	13	25										G	7577099	C	G	7577099	3	3	84	1	0	0	0	0	1	0	0	0	16378	913	32	1	447	1	TP53	17	7577099	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	213	7577099	73618111	117	25393										
KDM6B	23135	broad.mit.edu	37	chr17	7751845	7751845	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cagcccccaccactactgctCctgctgtcgccgtcaccacc	6	22	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7751845C>G	uc002giw.1	+	11	2615	c.2239C>G	c.(2239-2241)CCT>GCT	p.P747A	KDM6B_uc002gix.2_Missense_Mutation_p.P49A	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	747	Pro-rich.|Thr-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CACTACTGCTCCTGCTGTCGC	0.408													0	0	0	0.021553	0	6	48										G	7751845	C	G	7751845	3	3	84	1	0	0	0	0	1	0	0	0	8138	855	30	1	2269	1	KDM6B	17	7751845	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	174746	7751845	73443365	118	25394										
CNTROB	116840	broad.mit.edu	37	chr17	7836462	7836462	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggatctcctgagtgattcatCagaaccccctgggctcaacc	9	14	4	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7836462C>T	uc002gjq.2	+	2	984	c.65C>T	c.(64-66)TCA>TTA	p.S22L	TRAPPC1_uc002gjo.1_5'Flank|CNTROB_uc002gjp.2_Missense_Mutation_p.S22L|CNTROB_uc002gjr.2_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	22					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				AGTGATTCATCAGAACCCCCT	0.602													0	0	0	0.024245	0	14	145										T	7836462	C	T	7836462	3	4	84	1	0	0	0	0	1	0	0	0	3651	838	29	1	67	1	CNTROB	17	7836462	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	84617	7836462	73358748	119	25395										
NCOR1	9611	broad.mit.edu	37	chr17	16089958	16089958	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcaaaagctgtgatgcctgaCtcacttcaagatgagaggaa	11	8	2	4			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:16089958C>T	uc002gpo.2	-	3	392	c.152G>A	c.(151-153)AGT>AAT	p.S51N	NCOR1_uc002gpn.2_Missense_Mutation_p.S51N|NCOR1_uc002gpp.1_Intron|NCOR1_uc002gpr.2_Intron|NCOR1_uc002gps.1_Missense_Mutation_p.S51N|NCOR1_uc010coz.1_5'UTR|NCOR1_uc010cpb.1_Missense_Mutation_p.S51N|NCOR1_uc010cpa.1_Missense_Mutation_p.S51N|NCOR1_uc002gpu.2_Missense_Mutation_p.S51N	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	51	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGATGCCTGACTCACTTCAAG	0.413													0	0	0	0.004482	0	9	61										T	16089958	C	T	16089958	3	4	84	1	0	0	0	0	1	0	0	0	10235	565	20	2	7346	2	NCOR1	17	16089958	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	8253496	16089958	65105252	120	25396										
ULK2	9706	broad.mit.edu	37	chr17	19685248	19685248	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctggtccaccaccacactctCctggatctggtacaaggaca	8	15	2	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:19685248C>G	uc002gwm.3	-	23	3102	c.2593G>C	c.(2593-2595)GAG>CAG	p.E865Q	ULK2_uc002gwn.2_Missense_Mutation_p.E865Q	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	865					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					ACCACACTCTCCTGGATCTGG	0.522													0	0	0	0.013537	0	13	102										G	19685248	C	G	19685248	3	3	84	1	0	0	0	0	1	0	0	0	16973	864	30	1	537	1	ULK2	17	19685248	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	3595290	19685248	61509962	121	25397										
SEZ6	124925	broad.mit.edu	37	chr17	27308687	27308687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	agcataggggactctgactcCggactccagggtccctcctt	11	14	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:27308687C>T	uc002hdp.2	-	2	620	c.426G>A	c.(424-426)CCG>CCA	p.P142P	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Silent_p.P142P|SEZ6_uc002hdq.1_Silent_p.P17P|SEZ6_uc010crz.1_Silent_p.P142P	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	142	Pro-rich.|Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			ACTCTGACTCCGGACTCCAGG	0.647													0	0	0	0.021553	0	5	36										T	27308687	C	T	27308687	2	4	84	1	0	0	0	0	0	0	0	1	14142	639	23	2		2	SEZ6	17	27308687	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	7623439	27308687	53886523	122	25398										
MYO1D	4642	broad.mit.edu	37	chr17	30986217	30986217	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tcacgtgcttcccgtagtctCgcatggtcttgacgccatgg	11	13	3	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:30986217C>T	uc002hho.1	-	17	2273	c.2261G>A	c.(2260-2262)CGA>CAA	p.R754Q	MYO1D_uc002hhp.1_Missense_Mutation_p.R754Q	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	754						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CCCGTAGTCTCGCATGGTCTT	0.532											OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00632	0	29	94										T	30986217	C	T	30986217	3	4	84	1	0	0	0	0	1	0	0	0	10071	884	31	1	783	1	MYO1D	17	30986217	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	3677530	30986217	50208993	123	25399										
PPP1R1B	84152	broad.mit.edu	37	chr17	37790282	37790282	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	aggaagaggaggatgatgaaGaagaggaagaagaagaggac	18	1	0	8			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:37790282G>C	uc002hrz.2	+	5	855	c.388G>C	c.(388-390)GAA>CAA	p.E130Q	PPP1R1B_uc002hsa.2_Missense_Mutation_p.E141Q|PPP1R1B_uc010cvx.2_Missense_Mutation_p.E97Q|PPP1R1B_uc002hsb.2_Missense_Mutation_p.E94Q|PPP1R1B_uc002hsc.2_Missense_Mutation_p.E94Q	NM_032192	NP_115568	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	130	Asp/Glu-rich (acidic).				signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ggatgatgaagaagaggaaga	0.423													0	0	0	0.020292	0	13	103										C	37790282	G	C	37790282	3	2	84	1	0	0	0	0	1	0	0	0	12368	943	33	1	406	1	PPP1R1B	17	37790282	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	6804065	37790282	43404928	124	25400										
KRT14	3861	broad.mit.edu	37	chr17	39740032	39740032	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	cttggtgaagaaccattcctCggcatccttgcggttcttct	9	12	2	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:39740032C>T	uc002hxf.1	-	4	968	c.907G>A	c.(907-909)GAG>AAG	p.E303K	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Missense_Mutation_p.E303K	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	303	Rod.|Coil 2.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				AACCATTCCTCGGCATCCTTG	0.542													0	0	0	0.024334	0	28	249										T	39740032	C	T	39740032	3	4	84	1	0	0	0	0	1	0	0	0	8451	893	31	1	531	1	KRT14	17	39740032	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	1949750	39740032	41455178	125	25401										
CCR10	2826	broad.mit.edu	37	chr17	40831910	40831910	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	acgaaggccgccaccagagcCaccacgacgcgcagcgcacg	12	18	0	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:40831910C>A	uc002iax.3	-	2	754	c.750G>T	c.(748-750)GTG>GTT	p.V250V	PLEKHH3_uc002iau.2_5'Flank|PLEKHH3_uc002iav.2_5'Flank|PLEKHH3_uc010cym.1_5'Flank|PLEKHH3_uc002iaw.2_5'Flank|CNTNAP1_uc002iay.2_5'Flank|CNTNAP1_uc010wgs.1_5'Flank	NM_016602	NP_057686	P46092	CCR10_HUMAN	CC chemokine receptor 10	250	Helical; Name=6; (Potential).					integral to plasma membrane					0		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		CCACCAGAGCCACCACGACGC	0.731													1	0	0.004672	0.004672	0.00472863	3	9										A	40831910	C	A	40831910	2	1	84	1	0	0	0	0	0	0	0	1	2940	581	21	4		4	CCR10	17	40831910	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	1091878	40831910	40363300	126	25402										
PIP5K1C	23396	broad.mit.edu	37	chr19	3642935	3642935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gtccagacgactgtgtgcgcCgcctgcagagatacagcaaa	12	12	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:3642935C>T	uc002lyj.1	-	14	1709	c.1652G>A	c.(1651-1653)CGG>CAG	p.R551Q	PIP5K1C_uc010xhq.1_Missense_Mutation_p.R551Q|PIP5K1C_uc010xhr.1_Missense_Mutation_p.R551Q	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	551					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CTGTGTGCGCCGCCTGCAGAG	0.468													0	0	0	0.010729	0	11	80										T	3642935	C	T	3642935	3	4	84	1	0	0	0	0	1	0	0	0	11941	652	23	2	374	2	PIP5K1C	19	3642935	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08		3642935	55486048	127	25403										
ANGPTL4	51129	broad.mit.edu	37	chr19	8429403	8429403	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gagcgcacccgcagtcagctGagcgcgctggagcggcgcct	16	15	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:8429403G>C	uc002mjq.1	+	1	393	c.198G>C	c.(196-198)CTG>CTC	p.L66L	ANGPTL4_uc002mjr.1_Silent_p.L66L|ANGPTL4_uc010xkc.1_5'UTR	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	66				LREHAERTRSQLSALER -> CANTGAHPQSAERAGA (in Ref. 5; AAD41088).	angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						GCAGTCAGCTGAGCGCGCTGG	0.716													0	0	0	0.004672	0	3	5										C	8429403	G	C	8429403	2	2	84	1	0	0	0	0	0	0	0	1	616	1277	45	1		1	ANGPTL4	19	8429403	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	4786468	8429403	50699580	128	25404										
MUC16	94025	broad.mit.edu	37	chr19	9087678	9087678	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atggtccatgcttttgtggcCggactggtgagattgggtga	16	6	0	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:9087678C>T	uc002mkp.2	-	1	4341	c.4137G>A	c.(4135-4137)CCG>CCA	p.P1379P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1379	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTTTGTGGCCGGACTGGTGA	0.458													0	0	0	0.021553	0	6	86										T	9087678	C	T	9087678	2	4	84	1	0	0	0	0	0	0	0	1	9973	639	23	2		2	MUC16	19	9087678	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	658275	9087678	50041305	129	25405										
USHBP1	83878	broad.mit.edu	37	chr19	17367354	17367354	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgggccagcctgggtccccaGaatggcctgcaccatggctt	13	14	0	1	rs141680124	byFrequency	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:17367354G>A	uc002nfs.1	-	9	1509	c.1396C>T	c.(1396-1398)CTG>TTG	p.L466L	USHBP1_uc002nfr.1_Silent_p.L92L|USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.L402L	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	466							PDZ domain binding			ovary(1)	1						TGGGTCCCCAGAATGGCCTGC	0.612													0	0	0	0.008871	0	21	85										A	17367354	G	A	17367354	2	1	84	1	0	0	0	0	0	0	0	1	17034	933	33	1		1	USHBP1	19	17367354	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	8279676	17367354	41761629	130	25406										
LRFN1	57622	broad.mit.edu	37	chr19	39805227	39805227	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttgcagtgcagggggttgccGccgaagctgacggtcagcgg	18	10	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:39805227G>A	uc002okw.2	-	1	750	c.750C>T	c.(748-750)GGC>GGT	p.G250G		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	250	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGGGGTTGCCGCCGAAGCTGA	0.697													0	0	0	0.004672	0	3	10										A	39805227	G	A	39805227	2	1	84	1	0	0	0	0	0	0	0	1	8937	1074	38	2		2	LRFN1	19	39805227	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	22437873	39805227	19323756	131	25407										
PRX	57716	broad.mit.edu	37	chr19	40902543	40902543	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tctggcactttcggcagctgCacctctggaagccgcacctc	10	16	2	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:40902543C>T	uc002onr.2	-	7	1985	c.1716G>A	c.(1714-1716)GTG>GTA	p.V572V	PRX_uc002onq.2_Silent_p.V433V|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	572	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].|22.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCGGCAGCTGCACCTCTGGAA	0.552													0	0	0	0.016723	0	13	225										T	40902543	C	T	40902543	2	4	84	1	0	0	0	0	0	0	0	1	12642	697	25	2		2	PRX	19	40902543	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	1097316	40902543	18226440	132	25408										
AXL	558	broad.mit.edu	37	chr19	41745178	41745178	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ctacactgctgctggggatgGaccctggagcctcccagtac	12	14	0	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:41745178G>C	uc010ehj.2	+	9	1434	c.1244G>C	c.(1243-1245)GGA>GCA	p.G415A	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Missense_Mutation_p.G415A|AXL_uc010ehk.2_Missense_Mutation_p.G415A	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	415	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GCTGGGGATGGACCCTGGAGC	0.617													0	0	0	0.008871	0	19	55										C	41745178	G	C	41745178	3	2	84	1	0	0	0	0	1	0	0	0	1238	1174	41	1	1278	1	AXL	19	41745178	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	842635	41745178	17383805	133	25409										
PSG9	5678	broad.mit.edu	37	chr19	43763021	43763021	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atactcacagaggacatttaGgatgactgggttactgcgga	12	7	1	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:43763021G>A	uc002owd.3	-	4	1075	c.976C>T	c.(976-978)CTA>TTA	p.L326L	PSG9_uc002owe.3_Intron|PSG9_uc010xwm.1_Silent_p.L233L|PSG9_uc002owf.3_Intron|PSG9_uc002owg.2_Intron|PSG9_uc002owh.2_Intron	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	326	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				AGGACATTTAGGATGACTGGG	0.507													0	0	0	0.008291	0	11	140										A	43763021	G	A	43763021	2	1	84	1	0	0	0	0	0	0	0	1	12662	991	35	2		2	PSG9	19	43763021	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	2017843	43763021	15365962	134	25410										
STRN4	29888	broad.mit.edu	37	chr19	47236403	47236403	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tcactcggctccactgccccGttgagctccagcgagcggcc	11	18	1	1	rs146403716		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:47236403G>A	uc002pfl.2	-	5	663	c.630C>T	c.(628-630)AAC>AAT	p.N210N	STRN4_uc002pfm.2_Silent_p.N210N|STRN4_uc010xyf.1_RNA|STRN4_uc010xyg.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	210						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		CCACTGCCCCGTTGAGCTCCA	0.662													0	0	0	0.001984	0	7	34										A	47236403	G	A	47236403	2	1	84	1	0	0	0	0	0	0	0	1	15330	1136	40	2		2	STRN4	19	47236403	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	3473382	47236403	11892580	135	25411										
DHDH	27294	broad.mit.edu	37	chr19	49442919	49442919	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tggtctttggagggcagaagCcagagaagatttctgtcgtg	15	6	2	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:49442919C>G	uc002ple.1	+	4	620	c.580C>G	c.(580-582)CCA>GCA	p.P194A		NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase	194					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		AGGGCAGAAGCCAGAGAAGAT	0.562													0	0	0	0.004482	0	7	102										G	49442919	C	G	49442919	3	3	84	1	0	0	0	0	1	0	0	0	4479	739	26	4	594	4	DHDH	19	49442919	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	2206516	49442919	9686064	136	25412										
ZNF615	284370	broad.mit.edu	37	chr19	52497324	52497324	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttttctcctgtatgagttttCtgatgtgtagtgagactgaa	10	5	2	4			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:52497324C>T	uc002pye.1	-	6	1297	c.1005G>A	c.(1003-1005)CAG>CAA	p.Q335Q	ZNF615_uc002pyf.1_Silent_p.Q346Q|ZNF615_uc002pyg.1_Silent_p.Q227Q|ZNF615_uc002pyh.1_Silent_p.Q346Q|ZNF615_uc010epi.1_Silent_p.Q342Q|ZNF615_uc010ydg.1_Silent_p.Q340Q	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	335	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TATGAGTTTTCTGATGTGTAG	0.423													0	0	0	0.009535	0	33	101										T	52497324	C	T	52497324	2	4	84	1	0	0	0	0	0	0	0	1	18037	912	32	1		1	ZNF615	19	52497324	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	3054405	52497324	6631659	137	25413										
SAPS1	22870	broad.mit.edu	37	chr19	55758399	55758399	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttcctcgtccagcagctcggGcaggctcaggtcctcccgct	11	17	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:55758399G>A	uc002qjw.3	-	2	315	c.73C>T	c.(73-75)CCC>TCC	p.P25S	SAPS1_uc002qjv.2_Missense_Mutation_p.P87S	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	25	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		AGCAGCTCGGGCAGGCTCAGG	0.612													0	0	0	0.001984	0	7	101										A	55758399	G	A	55758399	3	1	84	1	0	0	0	0	1	0	0	0	13836	1203	42	2	2664	2	SAPS1	19	55758399	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	3261075	55758399	3370584	138	25414										
ASXL1	171023	broad.mit.edu	37	chr20	31021672	31021672	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	acaattgaaagtgttcacacCgaaaagccacagcccactaa	6	12	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr20:31021672C>G	uc002wxs.2	+	11	2097	c.1671C>G	c.(1669-1671)ACC>ACG	p.T557T	ASXL1_uc010geb.2_Silent_p.T448T	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	557					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GTGTTCACACCGAAAAGCCAC	0.537			F|N|Mis		MDS|CMML								0	0	0	0.01892	0	24	128										G	31021672	C	G	31021672	2	3	84	1	0	0	0	0	0	0	0	1	1066	639	23	4		4	ASXL1	20	31021672	Silent	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08		31021672	32003848	139	25415										
ARFGEF2	10564	broad.mit.edu	37	chr20	47639592	47639592	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ttatcatctaacatagatcaGaaactgtttgccagcctcct	5	11	3	2			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr20:47639592G>T	uc002xtx.3	+	35	4781	c.4629G>T	c.(4627-4629)CAG>CAT	p.Q1543H	ARFGEF2_uc010zyf.1_Missense_Mutation_p.Q836H	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1543					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			ACATAGATCAGAAACTGTTTG	0.318													1	0	3.07112e-06	0.010729	3.1659e-06	9	120										T	47639592	G	T	47639592	3	4	84	1	0	0	0	0	1	0	0	0	853	933	33	3	4767	3	ARFGEF2	20	47639592	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	16617920	47639592	15385928	140	25416										
DGCR8	54487	broad.mit.edu	37	chr22	20073753	20073753	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	ggccgcctcctcatagacccGaactgtagtggccacagccc	10	17	1	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:20073753G>A	uc002zri.2	+	2	617	c.267G>A	c.(265-267)CCG>CCA	p.P89P	DGCR8_uc010grz.2_Silent_p.P89P|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	89	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TCATAGACCCGAACTGTAGTG	0.567													0	0	0	0.008291	0	9	66										A	20073753	G	A	20073753	2	1	84	1	0	0	0	0	0	0	0	1	4464	1045	37	1		1	DGCR8	22	20073753	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		20073753	31230813	141	25417										
THOC5	8563	broad.mit.edu	37	chr22	29917075	29917075	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	gcaactcaggactgagtcagGagacagcaagtcactagaaa	11	9	3	3			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:29917075G>C	uc003afr.2	-	14	1524	c.1189C>G	c.(1189-1191)CCT>GCT	p.P397A	THOC5_uc003afq.2_Missense_Mutation_p.P58A|THOC5_uc003afs.2_Missense_Mutation_p.P397A|THOC5_uc003aft.2_Missense_Mutation_p.P397A|THOC5_uc003afu.2_Missense_Mutation_p.P397A|THOC5_uc010gvo.2_Missense_Mutation_p.P141A	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	397					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ACTGAGTCAGGAGACAGCAAG	0.453													0	0	0	0.016522	0	23	114										C	29917075	G	C	29917075	3	2	84	1	0	0	0	0	1	0	0	0	15865	1174	41	1	894	1	THOC5	22	29917075	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	9843322	29917075	21387491	142	25418										
DEPDC5	9681	broad.mit.edu	37	chr22	32242867	32242867	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atgactgggcccatttccacGcattctctggagtcaactgc	9	13	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:32242867G>A	uc003als.2	+	31	3184	c.3042G>A	c.(3040-3042)ACG>ACA	p.T1014T	DEPDC5_uc011als.1_Silent_p.T945T|DEPDC5_uc011alu.1_Silent_p.T1023T|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Silent_p.T1014T|DEPDC5_uc003alu.2_Silent_p.T463T|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Silent_p.T344T|DEPDC5_uc003alw.2_Silent_p.T312T|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_Silent_p.T18T	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1014					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CCATTTCCACGCATTCTCTGG	0.552													0	0	0	0.028581	0	16	53										A	32242867	G	A	32242867	2	1	84	1	0	0	0	0	0	0	0	1	4442	1074	38	2		2	DEPDC5	22	32242867	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	2325792	32242867	19061699	143	25419										
WBP2NL	164684	broad.mit.edu	37	chr22	42415340	42415340	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	tgaagcggtctccgaatgtgGagctctccttcccacagcga	11	13	2	1			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:42415340G>A	uc011ape.1	+	3	104	c.88G>A	c.(88-90)GAG>AAG	p.E30K	WBP2NL_uc003bbt.2_Missense_Mutation_p.E30K|WBP2NL_uc011apk.1_Intron|WBP2NL_uc003bbu.2_RNA|WBP2NL_uc003bbv.1_5'Flank	NM_152613	NP_689826	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	30					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2						TCCGAATGTGGAGCTCTCCTT	0.413													0	0	0	0.00308	0	6	75										A	42415340	G	A	42415340	3	1	84	1	0	0	0	0	1	0	0	0	17257	1175	41	1	94	1	WBP2NL	22	42415340	Missense_Mutation	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08	10172473	42415340	8889226	144	25420										
ATP7A	538	broad.mit.edu	37	chrX	77275742	77275742	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	atctttactctccatacaggGgaggcaatgcctgtggctaa	10	10	2	0	rs150976855		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chrX:77275742G>C	uc004ecx.3	+	13	2788	c.2628G>C	c.(2626-2628)GGG>GGC	p.G876G		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	876	Cytoplasmic (Potential).		G -> R (in MNKD).|G -> E (in MNKD).		ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TCCATACAGGGGAGGCAATGC	0.393													0	0	0	0.013537	0	10	46										C	77275742	G	C	77275742	2	2	84	1	0	0	0	0	0	0	0	1	1190	1246	43	4		4	ATP7A	23	77275742	Silent	SNP	G	TCGA-FD-A3SP-01A-31D-A22Z-08		77275742	77994818	145	25421										
DIAPH2	1730	broad.mit.edu	37	chrX	96213049	96213049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.289655172413793	42	9.11788238829207e-11	2.95141613754726	4.29661941112323	2.47463523045705	0.0566224795386481	0.143188854489164	28	caccaccccttggaggagttCctcctcccccaggaatatca	7	17	1	0			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chrX:96213049C>T	uc004efu.3	+	16	2233	c.1837C>T	c.(1837-1839)CCT>TCT	p.P613S	DIAPH2_uc004eft.3_Missense_Mutation_p.P613S	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	613	Poly-Pro.|FH1.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						TGGAGGAGTTCCTCCTCCCCC	0.478													0	0	0	0.024245	0	16	25										T	96213049	C	T	96213049	3	4	84	1	0	0	0	0	1	0	0	0	4519	855	30	1	1899	1	DIAPH2	23	96213049	Missense_Mutation	SNP	C	TCGA-FD-A3SP-01A-31D-A22Z-08	18937307	96213049	59057511	146	25422										
DNAJC11	55735	broad.mit.edu	37	chr1	6696194	6696194	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cacactgctttggtatccggAgggcctcactgtccagcacc	10	15	1	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:6696194A>G	uc001aof.2	-	15	1743	c.1637T>C	c.(1636-1638)CTC>CCC	p.L546P	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Missense_Mutation_p.L494P|DNAJC11_uc010nzu.1_Missense_Mutation_p.L456P	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	546					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTATCCGGAGGGCCTCACT	0.607													0	0	0	0.00308	0	8	38										G	6696194	A	G	6696194	3	3	85	1	0	0	0	0	1	0	0	0	4630	304	11	5	50	5	DNAJC11	1	6696194	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08		6696194	242554427	1	25423										
WASF2	10163	broad.mit.edu	37	chr1	27736473	27736473	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gaggtgggaaagatgggggtGagggtggtggaggcgtccct	23	4	0	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:27736473G>A	uc001bof.1	-	8	1268	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L	WASF2_uc010ofl.1_Intron	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	351					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		AGATGGGGGTGAGGGTGGTGG	0.637													0	0	0	0.020292	0	13	55										A	27736473	G	A	27736473	3	1	85	1	0	0	0	0	1	0	0	0	17250	1294	45	1	452	1	WASF2	1	27736473	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	21040279	27736473	221514148	2	25424										
PGM1	5236	broad.mit.edu	37	chr1	64117350	64117350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cttcttccaggtatgattacGaggaggtggaagctgagggc	15	7	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:64117350G>A	uc001dbh.2	+	9	1504	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	PGM1_uc010ooy.1_Missense_Mutation_p.E234K|PGM1_uc010ooz.1_Missense_Mutation_p.E449K	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	431					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GTATGATTACGAGGAGGTGGA	0.498													0	0	0	0.006214	0	10	20										A	64117350	G	A	64117350	3	1	85	1	0	0	0	0	1	0	0	0	11797	1059	37	1	1629	1	PGM1	1	64117350	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	36380877	64117350	185133271	3	25425										
GBP6	163351	broad.mit.edu	37	chr1	89845982	89845982	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	caaacatccaattttcccagGgagtgcatcaggcgtttctt	8	11	2	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:89845982G>A	uc001dnf.2	+	6	937	c.663G>A	c.(661-663)AGG>AGA	p.R221R	GBP6_uc010ost.1_Silent_p.R91R	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	221							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATTTTCCCAGGGAGTGCATCA	0.408													0	0	0	0.00308	0	7	74										A	89845982	G	A	89845982	2	1	85	1	0	0	0	0	0	0	0	1	6278	1223	43	2		2	GBP6	1	89845982	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	25728632	89845982	159404639	4	25426										
SLC6A17	388662	broad.mit.edu	37	chr1	110709723	110709723	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tggaggaggagctggatgcaGaggaccggccggcctggaac	19	9	0	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:110709723G>A	uc009wfq.2	+	2	633	c.172G>A	c.(172-174)GAG>AAG	p.E58K		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	58	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GCTGGATGCAGAGGACCGGCC	0.612													0	0	0	0.014758	0	5	15										A	110709723	G	A	110709723	3	1	85	1	0	0	0	0	1	0	0	0	14680	943	33	1	174	1	SLC6A17	1	110709723	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	20863741	110709723	138540898	5	25427										
BCAS2	10286	broad.mit.edu	37	chr1	115118216	115118216	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gaaaaaggttcttactcattGtatactttccaggcattaca	6	8	2	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:115118216G>T	uc001efa.2	-	4	467	c.414C>A	c.(412-414)TAC>TAA	p.Y138*	DENND2C_uc001eez.2_RNA	NM_005872	NP_005863	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	138	Potential.				mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			large_intestine(1)	1	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTACTCATTGTATACTTTCC	0.274													1	0	1.56452e-12	0.007413	1.70444e-12	19	49										T	115118216	G	T	115118216	4	4	85	1	0	0	0	0	0	1	0	0	1351	1372	48	4	279	4	BCAS2	1	115118216	Nonsense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	4408493	115118216	134132405	6	25428										
PHGDH	26227	broad.mit.edu	37	chr1	120254678	120254678	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aatctgcggaaagtgctcatCagtgacagcctggacccttg	11	11	3	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:120254678C>T	uc001ehz.2	+	1	260	c.33C>T	c.(31-33)ATC>ATT	p.I11I	PHGDH_uc009whl.2_5'UTR|PHGDH_uc009whm.2_5'UTR|PHGDH_uc001eia.2_Silent_p.I11I|PHGDH_uc009whn.2_Silent_p.I11I	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	11					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	AAGTGCTCATCAGTGACAGCC	0.552													0	0	0	0.016723	0	13	53										T	120254678	C	T	120254678	2	4	85	1	0	0	0	0	0	0	0	1	11841	816	29	1		1	PHGDH	1	120254678	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	5136462	120254678	128995943	7	25429										
GON4L	54856	broad.mit.edu	37	chr1	155774915	155774915	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gaacgcgttcgaaatgcaatGagactgtcatccatgggctg	12	9	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:155774915G>A	uc001flz.2	-	11	1567	c.1470C>T	c.(1468-1470)CTC>CTT	p.L490L	GON4L_uc001fly.1_Silent_p.L490L|GON4L_uc009wrh.1_Silent_p.L490L|GON4L_uc001fma.1_Silent_p.L490L|GON4L_uc001fmc.2_Silent_p.L490L|GON4L_uc001fmd.3_Silent_p.L490L|GON4L_uc009wri.2_Silent_p.L76L|GON4L_uc009wrj.1_Silent_p.L5L|GON4L_uc001fme.2_Silent_p.L318L|GON4L_uc001fmf.2_Silent_p.L184L	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	490					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAAATGCAATGAGACTGTCAT	0.458													0	0	0	0.007291	0	28	56										A	155774915	G	A	155774915	2	1	85	1	0	0	0	0	0	0	0	1	6572	1277	45	1		1	GON4L	1	155774915	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	35520237	155774915	93475706	8	25430										
ELF3	1999	broad.mit.edu	37	chr1	201983027	201983028	+	Frame_Shift_Ins	INS	-	-	A													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cggagctcaacgagggcctcINSatgaagtgggagaatcggca							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:201983027_201983028insA	uc001gxg.3	+	7	4068_4069	c.876_877insA	c.(874-879)CTCATGfs	p.L292fs	ELF3_uc001gxi.3_Frame_Shift_Ins_p.L292fs|ELF3_uc001gxh.3_Frame_Shift_Ins_p.L292fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	292_293	ETS.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						ACGAGGGCCTCATGAAGTGGGA	0.574																		7	20	---	---								A	201983028	-	A	201983027	7	5	85	1	0	1	1	0	0	0	0	0	5055	813	29	0	902	0	ELF3	1	201983027	Frame_Shift_Ins	INS	-	TCGA-FD-A3SQ-01A-21D-A22Z-08	46208112	201983027	47267594	9	25431										
BTG2	7832	broad.mit.edu	37	chr1	203276391	203276391	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gctgctgcccagcgagctgaCcctgtgggtggacccctatg	14	14	0	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:203276391C>T	uc001gzq.2	+	2	373	c.302C>T	c.(301-303)ACC>ATC	p.T101I	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	101					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			AGCGAGCTGACCCTGTGGGTG	0.642													0	0	0	0.021553	0	6	43										T	203276391	C	T	203276391	3	4	85	1	0	0	0	0	1	0	0	0	1554	507	18	2	308	2	BTG2	1	203276391	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	1293364	203276391	45974230	10	25432										
RGS7	6000	broad.mit.edu	37	chr1	241094020	241094020	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgagagatggcactgaccatAatctgtgttttccggctccc	10	11	1	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:241094020A>T	uc001hyv.2	-	6	712	c.382T>A	c.(382-384)TAT>AAT	p.Y128N	RGS7_uc010pyh.1_Missense_Mutation_p.Y102N|RGS7_uc010pyj.1_Missense_Mutation_p.Y44N|RGS7_uc001hyu.2_Missense_Mutation_p.Y128N|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Missense_Mutation_p.Y128N	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	128					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CACTGACCATAATCTGTGTTT	0.373													0	0	0	0.01441	0	131	96										T	241094020	A	T	241094020	3	4	85	1	0	0	0	0	1	0	0	0	13310	362	13	5	1133	5	RGS7	1	241094020	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08	37817629	241094020	8156601	11	25433										
OR6F1	343169	broad.mit.edu	37	chr1	247875460	247875460	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aaccacaacagcaatcacaaAggccacaagctctactgcct	5	15	2	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:247875460A>G	uc001idj.1	-	1	598	c.598T>C	c.(598-600)TTT>CTT	p.F200L		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCAATCACAAAGGCCACAAGC	0.537													0	0	0	0.007413	0	20	144										G	247875460	A	G	247875460	3	3	85	1	0	0	0	0	1	0	0	0	11201	72	3	5	332	5	OR6F1	1	247875460	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08	6781440	247875460	1375161	12	25434										
OR2T1	26696	broad.mit.edu	37	chr1	248569879	248569879	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ccgggtctgttggatgattaTagcaggttcctggtttgggg	16	6	1	1	rs138350213		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:248569879T>A	uc010pzm.1	+	1	584	c.584T>A	c.(583-585)ATA>AAA	p.I195K		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	195	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGATGATTATAGCAGGTTCC	0.537													0	0	0	0.020292	0	15	139										A	248569879	T	A	248569879	3	1	85	1	0	0	0	0	1	0	0	0	11016	1406	49	5	586	5	OR2T1	1	248569879	Missense_Mutation	SNP	T	TCGA-FD-A3SQ-01A-21D-A22Z-08	694419	248569879	680742	13	25435										
ROCK2	9475	broad.mit.edu	37	chr2	11367412	11367412	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cataaaggaaaacacctacaGaccaccaatcacattctcgc	4	14	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:11367412G>A	uc002rbd.1	-	6	1285	c.836C>T	c.(835-837)TCT>TTT	p.S279F		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	279	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AACACCTACAGACCACCAATC	0.363													0	0	0	0.01441	0	53	113										A	11367412	G	A	11367412	3	1	85	1	0	0	0	0	1	0	0	0	13518	942	33	1	3442	1	ROCK2	2	11367412	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08		11367412	231831961	14	25436										
ADD2	119	broad.mit.edu	37	chr2	70903954	70903954	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tcggctcttctcggcaatgaCgctcgccaggagctgggact	13	13	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:70903954C>T	uc002sgz.2	-	13	2032	c.1567G>A	c.(1567-1569)GTC>ATC	p.V523I	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Missense_Mutation_p.V523I|ADD2_uc002sha.2_Missense_Mutation_p.V217I|ADD2_uc002sgx.2_Missense_Mutation_p.V523I|ADD2_uc010fdt.1_Missense_Mutation_p.V523I|ADD2_uc002shc.1_Missense_Mutation_p.V523I|ADD2_uc002shd.1_Missense_Mutation_p.V217I|ADD2_uc010fdu.1_Missense_Mutation_p.V539I	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	523					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TCGGCAATGACGCTCGCCAGG	0.602													0	0	0	0.013537	0	12	53										T	70903954	C	T	70903954	3	4	85	1	0	0	0	0	1	0	0	0	305	536	19	2	806	2	ADD2	2	70903954	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	59536542	70903954	172295419	15	25437										
RGPD4	285190	broad.mit.edu	37	chr2	108488251	108488251	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgctttggatgatagtgtcaGtagtagctcagtacatgctt	11	6	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:108488251G>A	uc010ywk.1	+	20	3873	c.3791G>A	c.(3790-3792)AGT>AAT	p.S1264N	RGPD4_uc002tdu.2_Missense_Mutation_p.S451N|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1264					intracellular transport		binding			skin(2)	2						GATAGTGTCAGTAGTAGCTCA	0.403													0	0	0	0.01441	0	122	253										A	108488251	G	A	108488251	3	1	85	1	0	0	0	0	1	0	0	0	13288	1029	36	2	3869	2	RGPD4	2	108488251	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	37584297	108488251	134711122	16	25438										
INHBB	3625	broad.mit.edu	37	chr2	121107201	121107201	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gactggatcatagcacccacCggctactacgggaactactg	10	13	1	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:121107201C>T	uc002tmn.2	+	2	1021	c.975C>T	c.(973-975)ACC>ACT	p.T325T		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	325					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				TAGCACCCACCGGCTACTACG	0.617													0	0	0	0.024334	0	26	74										T	121107201	C	T	121107201	2	4	85	1	0	0	0	0	0	0	0	1	7742	639	23	2		2	INHBB	2	121107201	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	12618950	121107201	122092172	17	25439										
XIRP2	129446	broad.mit.edu	37	chr2	168107280	168107280	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tcaccaacttttatcacaatAgaatctactgcccgacgaac	4	13	3	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:168107280A>G	uc002udx.2	+	8	9396	c.9378A>G	c.(9376-9378)ATA>ATG	p.I3126M	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.I2951M|XIRP2_uc010fpq.2_Missense_Mutation_p.I2904M|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2951					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTATCACAATAGAATCTACTG	0.443													0	0	0	0.00499	0	18	86										G	168107280	A	G	168107280	3	3	85	1	0	0	0	0	1	0	0	0	17427	410	15	5	9408	5	XIRP2	2	168107280	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08	47000079	168107280	75092093	18	25440										
LRP2	4036	broad.mit.edu	37	chr2	170011072	170011072	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agatgagagattatattttcGaattcggacattgtcaggca	10	5	1	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:170011072G>A	uc002ues.2	-	66	12406	c.12193C>T	c.(12193-12195)CGA>TGA	p.R4065*		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4065	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTATATTTTCGAATTCGGACA	0.378													0	0	0	0.027356	0	29	58										A	170011072	G	A	170011072	4	1	85	1	0	0	0	0	0	1	0	0	8956	1066	37	1	1830	1	LRP2	2	170011072	Nonsense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	1903792	170011072	73188301	19	25441										
TTN	7273	broad.mit.edu	37	chr2	179532370	179532370	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	attggtgttatataccttttGctagtttgggttttgtcttt	9	4	1	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:179532370G>A	uc010zfk.1	-	6	694	c.146C>T	c.(145-147)GCA>GTA	p.A49V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11243							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATACCTTTTGCTAGTTTGGG	0.294													0	0	0	0.010504	0	18	104										A	179532370	G	A	179532370	3	1	85	1	0	0	0	0	1	0	0	0	16732	1334	46	2		2	TTN	2	179532370	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	9521298	179532370	63667003	20	25442										
TTN	7273	broad.mit.edu	37	chr2	179640412	179640412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	caggtttaaaagttggaatcGtgattttgccttcttcggca	10	7	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:179640412G>A	uc010zfg.1	-	28	6403	c.6179C>T	c.(6178-6180)ACG>ATG	p.T2060M	TTN_uc010zfh.1_Missense_Mutation_p.T2014M|TTN_uc010zfi.1_Missense_Mutation_p.T2014M|TTN_uc010zfj.1_Missense_Mutation_p.T2014M|TTN_uc002unb.2_Missense_Mutation_p.T2060M|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2060							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTGGAATCGTGATTTTGCC	0.423													0	0	0	0.028581	0	17	110										A	179640412	G	A	179640412	3	1	85	1	0	0	0	0	1	0	0	0	16732	1145	40	2	105149	2	TTN	2	179640412	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	108042	179640412	63558961	21	25443										
DNER	92737	broad.mit.edu	37	chr2	230450646	230450646	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ccctgaagcctgaaggggggTcacacttcgtccatctatga	11	12	2	3	rs72987941	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:230450646T>A	uc002vpv.2	-	4	922	c.775A>T	c.(775-777)ACC>TCC	p.T259S	DNER_uc010zly.1_5'UTR	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	259	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity	p.T259P(1)		lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGAAGGGGGGTCACACTTCGT	0.517													0	0	0	0.009096	0	4	59										A	230450646	T	A	230450646	3	1	85	1	0	0	0	0	1	0	0	0	4667	1667	58	5	1478	5	DNER	2	230450646	Missense_Mutation	SNP	T	TCGA-FD-A3SQ-01A-21D-A22Z-08	50810234	230450646	12748727	22	25444										
UGT1A10	54575	broad.mit.edu	37	chr2	234545237	234545237	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctgctgacctgtggctttgcCgaggcagggaagctgctggt	16	10	0	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:234545237C>T	uc002vur.2	+	1	115	c.69C>T	c.(67-69)GCC>GCT	p.A23A	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Silent_p.A23A	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	23				MARAGWTSPVPLCVCLLLTCGFA -> MAPRRVDQPRSFMC VSTADLWLC (in Ref. 1).	flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTGGCTTTGCCGAGGCAGGGA	0.597													0	0	0	0.021523	0	26	89										T	234545237	C	T	234545237	2	4	85	1	0	0	0	0	0	0	0	1	16942	639	23	2		2	UGT1A10	2	234545237	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	4094591	234545237	8654136	23	25445										
RTP3	83597	broad.mit.edu	37	chr3	46542025	46542025	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gttcacacaagagaacatctCaaggatcctgaaaaacctgg	8	10	2	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:46542025C>G	uc003cps.1	+	2	403	c.335C>G	c.(334-336)TCA>TGA	p.S112*		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	112	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		GAGAACATCTCAAGGATCCTG	0.458													0	0	0	0.021022	0	39	87										G	46542025	C	G	46542025	4	3	85	1	0	0	0	0	0	1	0	0	13735	838	29	1	341	1	RTP3	3	46542025	Nonsense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		46542025	151480405	24	25446										
TCTA	6988	broad.mit.edu	37	chr3	49450045	49450047	+	In_Frame_Del	DEL	TAC	TAC	-													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gcgtgggggttctacgggaaTacagtgaccgggttgtatca							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:49450045_49450047delTAC	uc003cwv.3	+	1	407_409	c.186_188delTAC	c.(184-189)AATACA>AAA	p.62_63NT>K	RHOA_uc010hku.2_5'Flank|RHOA_uc003cwu.2_5'Flank	NM_022171	NP_071503	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	62_63	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTACGGGAATACAGTGACCGGG	0.635																		30	84	---	---								-	49450047	TAC	-	49450045	7	5	85	1	0	1	0	1	0	0	0	0	15713	1403	49	0	188	0	TCTA	3	49450045	In_Frame_Del	DEL	TAC	TCGA-FD-A3SQ-01A-21D-A22Z-08	2908020	49450045	148572385	25	25447										
DOCK3	1795	broad.mit.edu	37	chr3	51266209	51266209	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tcatcttccagcgcagcaccAaagagtctttcttcatctcc	5	15	6	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:51266209A>T	uc011bds.1	+	18	1788	c.1765A>T	c.(1765-1767)AAA>TAA	p.K589*		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	589	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCGCAGCACCAAAGAGTCTTT	0.517													0	0	0	0.020292	0	14	43										T	51266209	A	T	51266209	4	4	85	1	0	0	0	0	0	1	0	0	4688	131	5	5	1835	5	DOCK3	3	51266209	Nonsense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08	1816164	51266209	146756221	26	25448										
PARP14	54625	broad.mit.edu	37	chr3	122419588	122419588	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gaagtactgaaggcagtggaCattgtcaagcaagtctggga	14	6	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:122419588C>G	uc003efq.3	+	6	2246	c.2187C>G	c.(2185-2187)GAC>GAG	p.D729E	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.D446E|PARP14_uc003efs.1_Missense_Mutation_p.D446E	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AGGCAGTGGACATTGTCAAGC	0.408													0	0	0	0.004672	0	3	22										G	122419588	C	G	122419588	3	3	85	1	0	0	0	0	1	0	0	0	11458	477	17	4	2209	4	PARP14	3	122419588	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	71153379	122419588	75602842	27	25449										
MCM2	4171	broad.mit.edu	37	chr3	127325534	127325534	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctgccccagctcagcatggtCaagtacaactgcaacaagtg	9	13	2	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:127325534C>G	uc003ejp.2	+	6	1032	c.975C>G	c.(973-975)GTC>GTG	p.V325V	MCM2_uc011bkm.1_Silent_p.V195V|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Silent_p.V209V	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	325					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						TCAGCATGGTCAAGTACAACT	0.612													0	0	0	0.01892	0	26	79										G	127325534	C	G	127325534	2	3	85	1	0	0	0	0	0	0	0	1	9386	813	29	1		1	MCM2	3	127325534	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	4905946	127325534	70696896	28	25450										
CLSTN2	64084	broad.mit.edu	37	chr3	140140011	140140011	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgagctatgacaaacaacacCagtatgagatcctggtgacc	9	10	0	4			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:140140011C>T	uc003etn.2	+	5	872	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	CLSTN2_uc003etm.2_Nonsense_Mutation_p.Q228*	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	228	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAAACAACACCAGTATGAGAT	0.502										HNSCC(16;0.037)			0	0	0	0.012213	0	34	97										T	140140011	C	T	140140011	4	4	85	1	0	0	0	0	0	1	0	0	3562	595	21	2	700	2	CLSTN2	3	140140011	Nonsense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	12814477	140140011	57882419	29	25451										
CLSTN2	64084	broad.mit.edu	37	chr3	140282913	140282913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cccaccagcacttcatccagGagactgaggctgccaaggaa	10	14	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:140282913G>A	uc003etn.2	+	16	2783	c.2593G>A	c.(2593-2595)GAG>AAG	p.E865K		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	865	Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTTCATCCAGGAGACTGAGGC	0.562										HNSCC(16;0.037)			0	0	0	0.027356	0	27	125										A	140282913	G	A	140282913	3	1	85	1	0	0	0	0	1	0	0	0	3562	1175	41	1	2655	1	CLSTN2	3	140282913	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	142902	140282913	57739517	30	25452										
FAM131A	131408	broad.mit.edu	37	chr3	184062488	184062488	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctggcctcccagctgctgggCgatgagctgcttctcgccaa	12	15	1	1	rs150189351	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:184062488C>T	uc003fog.2	+	3	2102	c.738C>T	c.(736-738)GGC>GGT	p.G246G	FAM131A_uc003fob.1_Silent_p.G154G|FAM131A_uc003foc.2_Silent_p.G192G|FAM131A_uc003foe.2_Silent_p.G192G	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	246						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCTGCTGGGCGATGAGCTGC	0.667													0	0	0	0.006214	0	9	100										T	184062488	C	T	184062488	2	4	85	1	0	0	0	0	0	0	0	1	5439	755	27	2		2	FAM131A	3	184062488	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	43779575	184062488	13959942	31	25453										
ATP13A4	84239	broad.mit.edu	37	chr3	193130158	193130158	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tttcattttgtactgtgcagGcactaaaagggaaaaccaaa	8	7	1	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:193130158G>A	uc003ftd.2	-	27	3125	c.3017C>T	c.(3016-3018)GCC>GTC	p.A1006V	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1006	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TACTGTGCAGGCACTAAAAGG	0.398													0	0	0	0.023175	0	39	124										A	193130158	G	A	193130158	3	1	85	1	0	0	0	0	1	0	0	0	1126	1203	42	2	589	2	ATP13A4	3	193130158	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	9067670	193130158	4892272	32	25454										
UBA6	55236	broad.mit.edu	37	chr4	68514897	68514897	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aagccttgggcagtccaagaGagccaatgcacaatgtcagc	11	11	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:68514897G>A	uc003hdg.3	-	14	1189	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	UBA6_uc003hdh.1_5'UTR	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	379					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						CAGTCCAAGAGAGCCAATGCA	0.393													0	0	0	0.020292	0	13	65										A	68514897	G	A	68514897	2	1	85	1	0	0	0	0	0	0	0	1	16829	929	33	1		1	UBA6	4	68514897	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08		68514897	122639379	33	25455										
HSD17B13	345275	broad.mit.edu	37	chr4	88226451	88226451	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aaaatcgctgaggcgcgttcAggaagaaacctgtacaaaaa	10	8	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:88226451A>T	uc003hqo.2	-	7	885	c.822T>A	c.(820-822)CCT>CCA	p.P274P	HSD17B13_uc010ikk.2_Silent_p.P238P	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	274						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AGGCGCGTTCAGGAAGAAACC	0.333													0	0	0	0.00308	0	8	24										T	88226451	A	T	88226451	2	4	85	1	0	0	0	0	0	0	0	1	7382	175	7	5		5	HSD17B13	4	88226451	Silent	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08	19711554	88226451	102927825	34	25456										
FAT4	79633	broad.mit.edu	37	chr4	126238269	126238269	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctaagcggcggggctaccttCaggtaaacgtgactgtgcaa	13	10	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:126238269C>T	uc003ifj.3	+	1	703	c.703C>T	c.(703-705)CAG>TAG	p.Q235*		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	235	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGGCTACCTTCAGGTAAACGT	0.597											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	36										T	126238269	C	T	126238269	4	4	85	1	0	0	0	0	0	1	0	0	5692	827	29	1	705	1	FAT4	4	126238269	Nonsense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	38011818	126238269	64916007	35	25457										
FAT4	79633	broad.mit.edu	37	chr4	126239451	126239451	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tacaagaggcagagactgacCggaggtccttccgtctggat	13	10	1	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:126239451C>A	uc003ifj.3	+	1	1885	c.1885C>A	c.(1885-1887)CGG>AGG	p.R629R		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	629	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGAGACTGACCGGAGGTCCTT	0.557													1	0	1.67942e-08	0.006122	1.78605e-08	18	51										A	126239451	C	A	126239451	2	1	85	1	0	0	0	0	0	0	0	1	5692	643	23	4		4	FAT4	4	126239451	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	1182	126239451	64914825	36	25458										
ELF2	1998	broad.mit.edu	37	chr4	139980487	139980487	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aatgcttcctgatccagtcaGatttgactttgtctgcagtt	8	9	2	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:139980487G>C	uc003ihp.1	-	9	1602	c.1396C>G	c.(1396-1398)CTG>GTG	p.L466V	ELF2_uc003ihm.1_Missense_Mutation_p.L418V|ELF2_uc003ihn.1_Missense_Mutation_p.L406V|ELF2_uc003iho.1_Missense_Mutation_p.L389V|ELF2_uc011chc.1_Missense_Mutation_p.L281V	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	478					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					GATCCAGTCAGATTTGACTTT	0.443													0	0	0	0.00499	0	18	72										C	139980487	G	C	139980487	3	2	85	1	0	0	0	0	1	0	0	0	5054	933	33	1	353	1	ELF2	4	139980487	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	13741036	139980487	51173789	37	25459										
DDX60L	91351	broad.mit.edu	37	chr4	169344916	169344916	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cagctatacttaaatctttcGaaattttgccttgttaaaga	5	7	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:169344916G>A	uc003irq.3	-	15	2161	c.1940C>T	c.(1939-1941)TCG>TTG	p.S647L	DDX60L_uc003irr.1_Missense_Mutation_p.S647L|DDX60L_uc003irs.1_Missense_Mutation_p.S374L	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	647							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TAAATCTTTCGAAATTTTGCC	0.308													0	0	0	0.004672	0	3	9										A	169344916	G	A	169344916	3	1	85	1	0	0	0	0	1	0	0	0	4379	1059	37	1	3276	1	DDX60L	4	169344916	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	29364429	169344916	21809360	38	25460										
EMB	133418	broad.mit.edu	37	chr5	49699204	49699204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gtaagattccccatcttcctCcaaaagttgtgttatcttca	5	11	3	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:49699204C>T	uc003jom.2	-	6	934	c.685G>A	c.(685-687)GAG>AAG	p.E229K	EMB_uc010ivq.2_Missense_Mutation_p.E23K|EMB_uc003jol.2_Missense_Mutation_p.E160K|EMB_uc011cpy.1_Missense_Mutation_p.E179K|EMB_uc010ivr.2_Missense_Mutation_p.E175K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	229	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CCATCTTCCTCCAAAAGTTGT	0.418													0	0	0	0.016723	0	13	57										T	49699204	C	T	49699204	3	4	85	1	0	0	0	0	1	0	0	0	5085	864	30	1	314	1	EMB	5	49699204	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		49699204	131216056	39	25461										
IL31RA	133396	broad.mit.edu	37	chr5	55212787	55212787	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cgaggatgccagaggggaccCgcccagaagccaaagagcag	15	12	0	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:55212787C>T	uc003jql.2	+	15	2199	c.2134C>T	c.(2134-2136)CGC>TGC	p.R712C	IL31RA_uc003jqm.2_Intron|IL31RA_uc003jqn.2_Intron|IL31RA_uc003jqo.2_Missense_Mutation_p.R570C	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	680	Cytoplasmic (Potential).				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				AGAGGGGACCCGCCCAGAAGC	0.483													0	0	0	0.008291	0	11	49										T	55212787	C	T	55212787	3	4	85	1	0	0	0	0	1	0	0	0	7691	652	23	2	2192	2	IL31RA	5	55212787	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	5513583	55212787	125702473	40	25462										
THBS4	7060	broad.mit.edu	37	chr5	79375841	79375841	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gactccaggaatgtgggctgGaaggacaaggtgtcctaccg	15	9	0	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:79375841G>A	uc003kgh.2	+	21	2948	c.2625G>A	c.(2623-2625)TGG>TGA	p.W875*	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	875	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ATGTGGGCTGGAAGGACAAGG	0.597													0	0	0	0.006214	0	9	34										A	79375841	G	A	79375841	4	1	85	1	0	0	0	0	0	1	0	0	15853	1183	41	1	2703	1	THBS4	5	79375841	Nonsense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	24163054	79375841	101539419	41	25463										
RASA1	5921	broad.mit.edu	37	chr5	86679590	86679590	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aatccacggatgttcaatatCatctcaggtaatcagctttt	6	9	4	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:86679590C>T	uc003kiw.2	+	21	2869	c.2751C>T	c.(2749-2751)ATC>ATT	p.I917I	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Silent_p.I740I|RASA1_uc011ctv.1_Silent_p.I750I|RASA1_uc011ctw.1_Silent_p.I751I|RASA1_uc010jaw.2_Silent_p.I739I	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	917	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGTTCAATATCATCTCAGGTA	0.274													0	0	0	0.021553	0	5	20										T	86679590	C	T	86679590	2	4	85	1	0	0	0	0	0	0	0	1	13060	816	29	1		1	RASA1	5	86679590	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	7303749	86679590	94235670	42	25464										
PCDHA13	56136	broad.mit.edu	37	chr5	140263361	140263361	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gcggcgggtgggcgagcgtgCgctgtcgagctacgtgtcgg	21	10	0	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:140263361C>A	uc003lif.2	+	1	1508	c.1508C>A	c.(1507-1509)GCG>GAG	p.A503E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A503E|PCDHA13_uc003lid.2_Missense_Mutation_p.A503E	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGTGCGCTGTCGAGC	0.672													1	0	0.000132079	0.008871	0.000137198	19	65										A	140263361	C	A	140263361	3	1	85	1	0	0	0	0	1	0	0	0	11523	768	27	4	1510	4	PCDHA13	5	140263361	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	53583771	140263361	40651899	43	25465										
ZNF354B	117608	broad.mit.edu	37	chr5	178310335	178310335	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	catttaaggacccatactgtGgagaaatgctatagatgtaa	9	6	0	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:178310335G>A	uc003mjl.2	+	5	1108	c.882G>A	c.(880-882)GTG>GTA	p.V294V	ZNF354B_uc003mjm.2_Silent_p.V294V	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCATACTGTGGAGAAATGCT	0.378													0	0	0	0.009535	0	31	81										A	178310335	G	A	178310335	2	1	85	1	0	0	0	0	0	0	0	1	17862	1335	47	2		2	ZNF354B	5	178310335	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	38046974	178310335	2604925	44	25466										
ADAMTS2	9509	broad.mit.edu	37	chr5	178579179	178579179	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	atagtcccgtccaaggggggCcccttcttggtcttgcaaaa	11	12	2	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:178579179C>T	uc003mjw.2	-	10	1593	c.1593G>A	c.(1591-1593)GGG>GGA	p.G531G	ADAMTS2_uc011dgm.1_Silent_p.G531G	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	531	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCAAGGGGGGCCCCTTCTTGG	0.592													0	0	0	0.021553	0	6	36										T	178579179	C	T	178579179	2	4	85	1	0	0	0	0	0	0	0	1	265	726	26	2		2	ADAMTS2	5	178579179	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	268844	178579179	2336081	45	25467										
OR2J2	26707	broad.mit.edu	37	chr6	29141694	29141694	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ggcccggaaaagaccatctcGtatgctggttgcatggttca	12	10	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:29141694G>A	uc011dlm.1	+	1	384	c.282G>A	c.(280-282)TCG>TCA	p.S94S		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGACCATCTCGTATGCTGGTT	0.473													0	0	0	0.006214	0	9	184										A	29141694	G	A	29141694	2	1	85	1	0	0	0	0	0	0	0	1	11003	1132	40	2		2	OR2J2	6	29141694	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08		29141694	141973373	46	25468										
ENPP1	5167	broad.mit.edu	37	chr6	132204911	132204911	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgccaatgtaccagagttttCaaggtaaataatgttaactc	7	7	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:132204911C>G	uc011ecf.1	+	22	2328	c.2308C>G	c.(2308-2310)CAA>GAA	p.Q770E		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	770	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CCAGAGTTTTCAAGGTAAATA	0.274													0	0	0	0.010504	0	21	44										G	132204911	C	G	132204911	3	3	85	1	0	0	0	0	1	0	0	0	5129	827	29	1	2394	1	ENPP1	6	132204911	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	103063217	132204911	38910156	47	25469										
VWC2	375567	broad.mit.edu	37	chr7	49951714	49951714	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	caccatatgccactgtacttAtgaggaaggcacatggagaa	10	9	0	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:49951714A>T	uc003tot.1	+	4	1467	c.911A>T	c.(910-912)TAT>TTT	p.Y304F		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	304					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						CACTGTACTTATGAGGAAGGC	0.493													0	0	0	0.024245	0	14	40										T	49951714	A	T	49951714	3	4	85	1	0	0	0	0	1	0	0	0	17240	449	16	5	921	5	VWC2	7	49951714	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08		49951714	109186949	48	25470										
ZCWPW1	55063	broad.mit.edu	37	chr7	100013666	100013666	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cctgaactgttttctttagtCggtcttcctgtctgtgctca	8	11	4	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:100013666C>T	uc003uut.2	-	8	931	c.683G>A	c.(682-684)CGA>CAA	p.R228Q	ZCWPW1_uc011kjq.1_Missense_Mutation_p.R108Q|ZCWPW1_uc003uur.2_Missense_Mutation_p.R108Q|ZCWPW1_uc003uus.2_Missense_Mutation_p.R108Q|ZCWPW1_uc011kjr.1_Missense_Mutation_p.R228Q|ZCWPW1_uc003uuu.1_Missense_Mutation_p.R228Q|ZCWPW1_uc011kjs.1_Missense_Mutation_p.R108Q	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	228							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTTCTTTAGTCGGTCTTCCTG	0.443													0	0	0	0.008291	0	11	130										T	100013666	C	T	100013666	3	4	85	1	0	0	0	0	1	0	0	0	17594	884	31	1	1307	1	ZCWPW1	7	100013666	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	50061952	100013666	59124997	49	25471										
CSMD1	64478	broad.mit.edu	37	chr8	2876065	2876065	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctctctgacatgagaccccaCaagcgtgtagccggtgttgc	11	13	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:2876065C>T	uc011kwk.1	-	52	8356	c.7966G>A	c.(7966-7968)GTG>ATG	p.V2656M	CSMD1_uc011kwj.1_Missense_Mutation_p.V1985M|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2656	Extracellular (Potential).|Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGAGACCCCACAAGCGTGTAG	0.498													0	0	0	0.01441	0	69	108										T	2876065	C	T	2876065	3	4	85	1	0	0	0	0	1	0	0	0	3944	478	17	2	2807	2	CSMD1	8	2876065	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		2876065	143487957	50	25472										
ADAM2	2515	broad.mit.edu	37	chr8	39604116	39604116	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aaaaatggccatctcattggTttggaatggtaaatgttctc	9	6	2	0	rs142592344	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:39604116T>A	uc003xnj.2	-	19	2124	c.2049A>T	c.(2047-2049)AAA>AAT	p.K683N	ADAM2_uc003xnk.2_Missense_Mutation_p.K664N|ADAM2_uc011lck.1_Missense_Mutation_p.K620N|ADAM2_uc003xnl.2_Missense_Mutation_p.K527N	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	683	Extracellular (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATCTCATTGGTTTGGAATGGT	0.299													0	0	0	0.01892	0	23	113										A	39604116	T	A	39604116	3	1	85	1	0	0	0	0	1	0	0	0	241	1722	60	5	166	5	ADAM2	8	39604116	Missense_Mutation	SNP	T	TCGA-FD-A3SQ-01A-21D-A22Z-08	36728051	39604116	106759906	51	25473										
DPY19L4	286148	broad.mit.edu	37	chr8	95751649	95751649	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ttctgtctttaggtgtttacGaactgacacacaataacaaa	6	8	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:95751649G>A	uc003ygx.2	+	5	476	c.352G>A	c.(352-354)GAA>AAA	p.E118K	DPY19L4_uc003ygy.2_Missense_Mutation_p.E55K	NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	118						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					AGGTGTTTACGAACTGACACA	0.313													0	0	0	0.00308	0	7	103										A	95751649	G	A	95751649	3	1	85	1	0	0	0	0	1	0	0	0	4743	1059	37	1	370	1	DPY19L4	8	95751649	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	56147533	95751649	50612373	52	25474										
C9orf41	138199	broad.mit.edu	37	chr9	77642981	77642983	+	In_Frame_Del	DEL	CTC	CTC	-													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aagtgctcacgctcaagcctCtcctcctcctcctcggtgct							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:77642981_77642983delCTC	uc004ajq.2	-	1	328_330	c.175_177delGAG	c.(175-177)GAGdel	p.E59del	C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	59										ovary(1)|skin(1)	2						GCTCAAGCCTCTCCTCCTCCTCC	0.547																		2	4	---	---								-	77642983	CTC	-	77642981	7	5	85	1	0	1	0	1	0	0	0	0	2482	912	32	0	1084	0	C9orf41	9	77642981	In_Frame_Del	DEL	CTC	TCGA-FD-A3SQ-01A-21D-A22Z-08		77642981	63570450	53	25475										
PDCL	5082	broad.mit.edu	37	chr9	125585294	125585294	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agcctgagtactgctaattaCcttcccactgatcttctcct	5	14	2	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:125585294C>A	uc004bmz.1	-	3	450	c.354_splice	c.e3+1	p.K118_splice	PDCL_uc004bna.2_Splice_Site_p.K118_splice	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like						signal transduction|visual perception						0						CTGCTAATTACCTTCCCACTG	0.478													1	0	3.54561e-26	0.009718	3.92654e-26	42	60										A	125585294	C	A	125585294	5	1	85	1	0	0	0	0	0	0	1	0	11626	521	18	4	558	4	PDCL	9	125585294	Splice_Site	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	47942313	125585294	15628137	54	25476										
SPTAN1	6709	broad.mit.edu	37	chr9	131388682	131388682	+	Frame_Shift_Del	DEL	T	T	-													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gcttccaggtggaggacctcTtcctgaccttcgccaaaaag							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:131388682delT	uc004bvl.3	+	48	6390	c.6277delT	c.(6277-6279)TTCfs	p.F2093fs	SPTAN1_uc004bvm.3_Frame_Shift_Del_p.F2098fs|SPTAN1_uc004bvn.3_Frame_Shift_Del_p.F2073fs|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2093	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGAGGACCTCTTCCTGACCTT	0.582																		38	90	---	---								-	131388682	T	-	131388682	7	5	85	1	0	1	0	1	0	0	0	0	15116	1609	56	0	6482	0	SPTAN1	9	131388682	Frame_Shift_Del	DEL	T	TCGA-FD-A3SQ-01A-21D-A22Z-08	5803388	131388682	9824749	55	25477										
ARHGAP21	57584	broad.mit.edu	37	chr10	24873643	24873643	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aaggtcagaggtactggtgcGtaggcgttccctggccagcc	15	11	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:24873643G>A	uc001isb.2	-	26	6062	c.5575C>T	c.(5575-5577)CGC>TGC	p.R1859C	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1858	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						GTACTGGTGCGTAGGCGTTCC	0.527													0	0	0	0.006122	0	18	74										A	24873643	G	A	24873643	3	1	85	1	0	0	0	0	1	0	0	0	871	1145	40	2	305	2	ARHGAP21	10	24873643	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08		24873643	110661104	56	25478										
ARHGAP21	57584	broad.mit.edu	37	chr10	24873919	24873919	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gggtctcagttttaaccgatCtgctattttcgttttccatg	8	9	2	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:24873919C>G	uc001isb.2	-	26	5786	c.5299G>C	c.(5299-5301)GAT>CAT	p.D1767H	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1766	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTTAACCGATCTGCTATTTTC	0.463													0	0	0	0.006122	0	19	86										G	24873919	C	G	24873919	3	3	85	1	0	0	0	0	1	0	0	0	871	913	32	1	581	1	ARHGAP21	10	24873919	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	276	24873919	110660828	57	25479										
ZNF438	220929	broad.mit.edu	37	chr10	31137576	31137576	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	acaaccctatgcacttctttCagatggccaaaatagactcg	6	12	2	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:31137576C>T	uc010qdz.1	-	7	2193	c.1758G>A	c.(1756-1758)CTG>CTA	p.L586L	ZNF438_uc001ivn.2_Silent_p.L537L|ZNF438_uc010qdy.1_Silent_p.L576L|ZNF438_uc001ivo.3_Silent_p.L150L|ZNF438_uc009xlg.2_Silent_p.L586L|ZNF438_uc001ivp.3_Silent_p.L576L|ZNF438_uc010qea.1_Silent_p.L586L|ZNF438_uc010qeb.1_Silent_p.L586L|ZNF438_uc010qec.1_Silent_p.L150L	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	586	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GCACTTCTTTCAGATGGCCAA	0.478													0	0	0	0.008361	0	31	88										T	31137576	C	T	31137576	2	4	85	1	0	0	0	0	0	0	0	1	17907	813	29	1		1	ZNF438	10	31137576	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	6263657	31137576	104397171	58	25480										
LIPA	3988	broad.mit.edu	37	chr10	91007301	91007301	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tttgagaaacttaccacattCatgtttgtttcaggatccac	6	9	2	1	rs145756015		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:91007301C>T	uc001kga.3	-	2	273	c.105G>A	c.(103-105)ATG>ATA	p.M35I	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|LIPA_uc009xtq.2_Missense_Mutation_p.M35I	NM_000235	NP_000226	P38571	LICH_HUMAN	lipase A precursor	35					lipid catabolic process	lysosome	lipase activity|sterol esterase activity				0		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		TTACCACATTCATGTTTGTTT	0.438													0	0	0	0.014758	0	4	21										T	91007301	C	T	91007301	3	4	85	1	0	0	0	0	1	0	0	0	8819	826	29	1	1130	1	LIPA	10	91007301	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	59869725	91007301	44527446	59	25481										
CPXM2	119587	broad.mit.edu	37	chr10	125526589	125526589	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctgcctcccagagcagcgtgTttaaatcaggaaagttgttg	11	9	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:125526589T>C	uc001lhk.1	-	10	1704	c.1379A>G	c.(1378-1380)AAC>AGC	p.N460S	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	460					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GAGCAGCGTGTTTAAATCAGG	0.527													0	0	0	0.016723	0	12	57										C	125526589	T	C	125526589	3	2	85	1	0	0	0	0	1	0	0	0	3838	1725	60	5	911	5	CPXM2	10	125526589	Missense_Mutation	SNP	T	TCGA-FD-A3SQ-01A-21D-A22Z-08	34519288	125526589	10008158	60	25482										
EBF3	253738	broad.mit.edu	37	chr10	131640400	131640400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cttggtcgttggcttgtgacGtctctgacacgttgacggct	13	10	1	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:131640400G>A	uc001lki.1	-	13	1384	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	451					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GGCTTGTGACGTCTCTGACAC	0.597													0	0	0	0.014323	0	23	73										A	131640400	G	A	131640400	3	1	85	1	0	0	0	0	1	0	0	0	4882	1145	40	2	346	2	EBF3	10	131640400	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	6113811	131640400	3894347	61	25483										
PAOX	196743	broad.mit.edu	37	chr10	135202547	135202547	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gaagaagtacttctgtgtctCacccaagtgctccggagagt	11	10	2	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:135202547C>T	uc001lmv.2	+	5	1289	c.1209C>T	c.(1207-1209)CTC>CTT	p.L403L	PAOX_uc001lmw.2_RNA|PAOX_uc001lmx.2_Silent_p.L403L|PAOX_uc001lmy.2_Missense_Mutation_p.S319L|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	541					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TTCTGTGTCTCACCCAAGTGC	0.502													0	0	0	0.016723	0	13	210										T	135202547	C	T	135202547	2	4	85	1	0	0	0	0	0	0	0	1	11423	838	29	1		1	PAOX	10	135202547	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	3562147	135202547	332200	62	25484										
CCKBR	887	broad.mit.edu	37	chr11	6290930	6290930	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gccattagaatcactctttaCgcagtgatcttcctgatgag	8	10	3	4			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:6290930C>T	uc001mcp.2	+	2	376	c.183C>T	c.(181-183)TAC>TAT	p.Y61Y	CCKBR_uc001mcq.2_Translation_Start_Site|CCKBR_uc001mcr.2_Silent_p.Y61Y|CCKBR_uc001mcs.2_Silent_p.Y61Y	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	61	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TCACTCTTTACGCAGTGATCT	0.532													0	0	0	0.028581	0	17	64										T	6290930	C	T	6290930	2	4	85	1	0	0	0	0	0	0	0	1	2881	547	19	2		2	CCKBR	11	6290930	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		6290930	128715586	63	25485										
CD6	923	broad.mit.edu	37	chr11	60781397	60781397	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctcccctccctcagccctccCcgtaatggtgaaccaccagc	6	21	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:60781397C>T	uc001nqq.2	+	8	1521	c.1298C>T	c.(1297-1299)CCC>CTC	p.P433L	CD6_uc001nqp.2_Missense_Mutation_p.P433L|CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.P433L	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	433	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						TCAGCCCTCCCCGTAATGGTG	0.557													0	0	0	0.021553	0	6	29										T	60781397	C	T	60781397	3	4	85	1	0	0	0	0	1	0	0	0	3028	623	22	2	1328	2	CD6	11	60781397	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	54490467	60781397	74225119	64	25486										
OMP	4975	broad.mit.edu	37	chr11	76814045	76814045	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agccagcggagtctgtgtacCgcctcaacttcacccagcag	10	15	3	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:76814045C>T	uc010rsk.1	+	1	160	c.160C>T	c.(160-162)CGC>TGC	p.R54C	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	54					sensory perception of smell|synaptic transmission						0						GTCTGTGTACCGCCTCAACTT	0.637													0	0	0	0.021553	0	6	30										T	76814045	C	T	76814045	3	4	85	1	0	0	0	0	1	0	0	0	10867	652	23	2	162	2	OMP	11	76814045	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	16032648	76814045	58192471	65	25487										
IQSEC3	440073	broad.mit.edu	37	chr12	266745	266745	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gttcagcagttccacaacccCgacaccatcttcatcctcgc	5	18	3	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:266745C>T	uc001qhw.1	+	4	1425	c.1419C>T	c.(1417-1419)CCC>CCT	p.P473P	IQSEC3_uc001qhu.1_Silent_p.P473P	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	776	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCACAACCCCGACACCATCT	0.602													0	0	0	0.014758	0	5	84										T	266745	C	T	266745	2	4	85	1	0	0	0	0	0	0	0	1	7819	639	23	2		2	IQSEC3	12	266745	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		266745	133585150	66	25488										
GUCY2C	2984	broad.mit.edu	37	chr12	14767865	14767865	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agtcagccagtaggtagtctCatttcctcttccctggtaag	9	11	3	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:14767865C>T	uc001rcd.2	-	26	3120	c.2983G>A	c.(2983-2985)GAG>AAG	p.E995K		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	995	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TAGGTAGTCTCATTTCCTCTT	0.483													0	0	0	0.009096	0	4	21										T	14767865	C	T	14767865	3	4	85	1	0	0	0	0	1	0	0	0	6896	835	29	1	246	1	GUCY2C	12	14767865	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	14501120	14767865	119084030	67	25489										
ANKS1B	56899	broad.mit.edu	37	chr12	100200436	100200436	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agcaactacttctgagtgtcCatattgagctgcacagtgta	9	9	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:100200436C>T	uc001tge.1	-	4	832	c.415G>A	c.(415-417)GGA>AGA	p.G139R	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Missense_Mutation_p.G139R	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	139	ANK 4.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TCTGAGTGTCCATATTGAGCT	0.398													0	0	0	0.008291	0	11	35										T	100200436	C	T	100200436	3	4	85	1	0	0	0	0	1	0	0	0	689	603	21	2	3711	2	ANKS1B	12	100200436	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	85432571	100200436	33651459	68	25490										
ZCCHC8	55596	broad.mit.edu	37	chr12	122958344	122958344	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gccaactctgctttttccttCtgacaaagtgatgtcacctc	6	13	3	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:122958344C>G	uc001ucn.2	-	14	1955	c.1824G>C	c.(1822-1824)CAG>CAC	p.Q608H	ZCCHC8_uc001ucl.2_Missense_Mutation_p.Q219H|ZCCHC8_uc001ucm.2_Missense_Mutation_p.Q370H|ZCCHC8_uc009zxp.2_Missense_Mutation_p.Q370H|ZCCHC8_uc009zxq.2_Missense_Mutation_p.Q370H	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	608						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		CTTTTTCCTTCTGACAAAGTG	0.493													0	0	0	0.01441	0	52	147										G	122958344	C	G	122958344	3	3	85	1	0	0	0	0	1	0	0	0	17591	912	32	1	303	1	ZCCHC8	12	122958344	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	22757908	122958344	10893551	69	25491										
FGF14	2259	broad.mit.edu	37	chr13	102527614	102527614	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gtagtagccttgcctgcaatAtaacctggtcactataccct	7	12	1	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr13:102527614A>G	uc001vpe.2	-	2	226	c.226T>C	c.(226-228)TAT>CAT	p.Y76H	FGF14_uc001vpf.2_Missense_Mutation_p.Y81H	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	76					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGCCTGCAATATAACCTGGTC	0.448													0	0	0	0.016723	0	12	45										G	102527614	A	G	102527614	3	3	85	1	0	0	0	0	1	0	0	0	5843	449	16	5	533	5	FGF14	13	102527614	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08		102527614	12642264	70	25492										
MBIP	51562	broad.mit.edu	37	chr14	36789701	36789701	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gtgtagggagcgaaagatttCgtagagcacctctcgggaga	15	7	1	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:36789701C>T	uc001wtm.2	-	1	182	c.94G>A	c.(94-96)GAA>AAA	p.E32K	MBIP_uc001wto.2_Missense_Mutation_p.E32K|MBIP_uc010tpy.1_5'UTR|MBIP_uc001wtn.2_Missense_Mutation_p.E32K	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	32					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		CGAAAGATTTCGTAGAGCACC	0.567													0	0	0	0.004482	0	9	30										T	36789701	C	T	36789701	3	4	85	1	0	0	0	0	1	0	0	0	9349	893	31	1	976	1	MBIP	14	36789701	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		36789701	70559839	71	25493										
SFTA3	253970	broad.mit.edu	37	chr14	36946212	36946212	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctcctgctttgtgacagcgtCgtgggatgcagcagggctgt	15	10	0	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:36946212C>T	uc001wtr.2	-	3	857	c.225G>A	c.(223-225)ACG>ACA	p.T75T	SFTA3_uc001wtq.2_RNA|SFTA3_uc001wts.2_RNA	NM_001101341	NP_001094811	P0C7M3	SFTA3_HUMAN	surfactant associated 3	75											0						GTGACAGCGTCGTGGGATGCA	0.532													0	0	0	0.006214	0	8	111										T	36946212	C	T	36946212	2	4	85	1	0	0	0	0	0	0	0	1	14188	871	31	1		1	SFTA3	14	36946212	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	156511	36946212	70403328	72	25494										
DAAM1	23002	broad.mit.edu	37	chr14	59798179	59798179	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgaagaagaaaagcattcctCagcccacaaatgccctgaaa	7	11	1	4			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:59798179C>T	uc001xdz.1	+	14	1938	c.1813C>T	c.(1813-1815)CAG>TAG	p.Q605*	DAAM1_uc001xea.1_Nonsense_Mutation_p.Q605*	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	605	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AAGCATTCCTCAGCCCACAAA	0.453													0	0	0	0.01892	0	25	81										T	59798179	C	T	59798179	4	4	85	1	0	0	0	0	0	1	0	0	4215	827	29	1	1863	1	DAAM1	14	59798179	Nonsense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	22851967	59798179	47551361	73	25495										
ZWILCH	55055	broad.mit.edu	37	chr15	66820228	66820229	+	Frame_Shift_Ins	INS	-	-	A													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gatggatttggtgattctacINSaaaaaaagacactgaggttg							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr15:66820228_66820229insA	uc002aqb.2	+	10	1193_1194	c.947_948insA	c.(946-948)ACAfs	p.T316fs	ZWILCH_uc010bhu.1_Frame_Shift_Ins_p.T202fs|ZWILCH_uc002aqa.2_Frame_Shift_Ins_p.T202fs|ZWILCH_uc010bhv.2_Frame_Shift_Ins_p.T202fs	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch	316					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						GGTGATTCTACAAAAAAAGACA	0.317																		26	46	---	---								A	66820229	-	A	66820228	7	5	85	1	0	1	1	0	0	0	0	0	18245	478	17	0	985	0	ZWILCH	15	66820228	Frame_Shift_Ins	INS	-	TCGA-FD-A3SQ-01A-21D-A22Z-08		66820228	35711164	74	25496										
CHD9	80205	broad.mit.edu	37	chr16	53348844	53348844	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aagtccagttccagttattaAtcttaaagatggaacgagac	8	7	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr16:53348844A>G	uc002ehb.2	+	35	7636	c.7472A>G	c.(7471-7473)AAT>AGT	p.N2491S	CHD9_uc002egy.2_Missense_Mutation_p.N2475S|CHD9_uc002ehc.2_Missense_Mutation_p.N2476S|CHD9_uc002ehf.2_Missense_Mutation_p.N1589S|CHD9_uc010cbw.2_Missense_Mutation_p.N557S	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2491					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CCAGTTATTAATCTTAAAGAT	0.428													0	0	0	0.006122	0	19	54										G	53348844	A	G	53348844	3	3	85	1	0	0	0	0	1	0	0	0	3332	101	4	5	7562	5	CHD9	16	53348844	Missense_Mutation	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08		53348844	37005909	75	25497										
SLC13A5	284111	broad.mit.edu	37	chr17	6606437	6606437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctgctgccccagagtggggcCttcaaaaatcacttgactcc	9	14	2	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:6606437C>T	uc002gdj.2	-	5	656	c.568G>A	c.(568-570)GGC>AGC	p.G190S	SLC13A5_uc010vtf.1_Missense_Mutation_p.G190S|SLC13A5_uc010clq.2_Missense_Mutation_p.G147S|SLC13A5_uc002gdk.2_Missense_Mutation_p.G173S|SLC13A5_uc002gdl.1_Missense_Mutation_p.G172S	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	190						integral to membrane	citrate transmembrane transporter activity				0						AGAGTGGGGCCTTCAAAAATC	0.627													0	0	0	0.014758	0	5	56										T	6606437	C	T	6606437	3	4	85	1	0	0	0	0	1	0	0	0	14395	681	24	2	1170	2	SLC13A5	17	6606437	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		6606437	74588773	76	25498										
ACAP1	9744	broad.mit.edu	37	chr17	7253548	7253548	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gaaacagccaacgctgacatCgtcaccctgtaagaatgcct	8	13	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:7253548C>G	uc002ggd.2	+	20	2270	c.2064C>G	c.(2062-2064)ATC>ATG	p.I688M	KCTD11_uc002gge.3_5'Flank	NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	688	Required for interaction with GULP1.|ANK 3.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						ACGCTGACATCGTCACCCTGT	0.672													0	0	0	0.016723	0	14	37										G	7253548	C	G	7253548	3	3	85	1	0	0	0	0	1	0	0	0	118	874	31	1	2142	1	ACAP1	17	7253548	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	647111	7253548	73941662	77	25499										
TMEM102	284114	broad.mit.edu	37	chr17	7340636	7340636	+	Frame_Shift_Del	DEL	G	G	-													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gagctcggccgagtgctcgaGgccgggacgttgcctcacta							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:7340636delG	uc002ggx.1	+	3	1611	c.1338delG	c.(1336-1338)GAGfs	p.E446fs	FGF11_uc010vtw.1_Intron|TMEM102_uc002ggy.1_Frame_Shift_Del_p.E446fs|FGF11_uc010cmh.1_5'Flank|FGF11_uc010cmi.2_5'Flank|FGF11_uc002ggz.2_5'Flank	NM_178518	NP_848613	Q8N9M5	TM102_HUMAN	transmembrane protein 102	446	Cytoplasmic (Potential).				regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding				0		Prostate(122;0.173)				GAGTGCTCGAGGCCGGGACGT	0.697																		2	4	---	---								-	7340636	G	-	7340636	7	5	85	1	0	1	0	1	0	0	0	0	16014	991	35	0	1344	0	TMEM102	17	7340636	Frame_Shift_Del	DEL	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	87088	7340636	73854574	78	25500										
MYO18A	399687	broad.mit.edu	37	chr17	27447754	27447754	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ccaaaggcttccaggagggtGtacagagcctgccacttctc	11	13	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:27447754G>A	uc002hdt.1	-	7	1766	c.1608C>T	c.(1606-1608)TAC>TAT	p.Y536Y	MYO18A_uc010wbc.1_Silent_p.Y78Y|MYO18A_uc002hds.2_Silent_p.Y78Y|MYO18A_uc010csa.1_Silent_p.Y536Y|MYO18A_uc002hdu.1_Silent_p.Y536Y|MYO18A_uc010wbd.1_Silent_p.Y205Y	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	536	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCAGGAGGGTGTACAGAGCCT	0.577													0	0	0	0.010729	0	9	59										A	27447754	G	A	27447754	2	1	85	1	0	0	0	0	0	0	0	1	10065	1372	48	2		2	MYO18A	17	27447754	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	20107118	27447754	53747456	79	25501										
ABCC3	8714	broad.mit.edu	37	chr17	48755296	48755296	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agctgctacccctacatcatCtccaaccggtcagaagccgc	7	17	3	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:48755296C>T	uc002isl.2	+	24	3650	c.3570C>T	c.(3568-3570)ATC>ATT	p.I1190I	ABCC3_uc002isn.2_5'Flank	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1190	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCTACATCATCTCCAACCGGT	0.577													0	0	0	0.008871	0	21	149										T	48755296	C	T	48755296	2	4	85	1	0	0	0	0	0	0	0	1	54	903	32	1		1	ABCC3	17	48755296	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	21307542	48755296	32439914	80	25502										
INSR	3643	broad.mit.edu	37	chr19	7117211	7117211	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ccccccgcctcctccctctgAcagtgcgaggaacggtccag	10	19	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:7117211A>G	uc002mgd.1	-	22	4114	c.4005T>C	c.(4003-4005)TGT>TGC	p.C1335C	INSR_uc002mge.1_Silent_p.C1323C	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1335	Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTCCCTCTGACAGTGCGAGG	0.597													0	0	0	0.027356	0	29	56										G	7117211	A	G	7117211	2	3	85	1	0	0	0	0	0	0	0	1	7773	273	10	5		5	INSR	19	7117211	Silent	SNP	A	TCGA-FD-A3SQ-01A-21D-A22Z-08		7117211	52011772	81	25503										
FBN3	84467	broad.mit.edu	37	chr19	8188893	8188893	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	acatggttccaatctcacatCtgcacgggggacagtcactg	10	12	3	0			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:8188893C>G	uc002mjf.2	-	22	2753	c.2732_splice	c.e22-1	p.D911_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AATCTCACATCTGCACGGGGG	0.617													0	0	0	0.004482	0	9	15										G	8188893	C	G	8188893	5	3	85	1	0	0	0	0	0	0	1	0	5704	927	32	1	5866	1	FBN3	19	8188893	Splice_Site	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	1071682	8188893	50940090	82	25504										
CLIP3	25999	broad.mit.edu	37	chr19	36508845	36508845	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cctcagccttggccccgtcaCgctgctgcaagctgcccaga	10	18	2	1	rs149100841		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:36508845C>T	uc010eeq.1	-	9	1514	c.1232G>A	c.(1231-1233)CGT>CAT	p.R411H	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.R411H	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	411					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGCCCCGTCACGCTGCTGCAA	0.612													0	0	0	0.020292	0	14	49										T	36508845	C	T	36508845	3	4	85	1	0	0	0	0	1	0	0	0	3534	536	19	2	431	2	CLIP3	19	36508845	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	28319952	36508845	22620138	83	25505										
ATP1A3	478	broad.mit.edu	37	chr19	42486133	42486133	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgggcgactgtcatgcggttCtgagtgagggtccctgtctt	15	9	3	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:42486133C>A	uc002osg.2	-	9	1273	c.1119G>T	c.(1117-1119)CAG>CAT	p.Q373H	ATP1A3_uc010xwf.1_Missense_Mutation_p.Q384H|ATP1A3_uc010xwg.1_Missense_Mutation_p.Q343H|ATP1A3_uc010xwh.1_Missense_Mutation_p.Q386H|ATP1A3_uc002osh.2_Missense_Mutation_p.Q373H	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	373	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TCATGCGGTTCTGAGTGAGGG	0.468													1	0	0.000442599	0.006214	0.000456218	8	177										A	42486133	C	A	42486133	3	1	85	1	0	0	0	0	1	0	0	0	1130	912	32	3	1982	3	ATP1A3	19	42486133	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	5977288	42486133	16642850	84	25506										
C19orf41	126123	broad.mit.edu	37	chr19	50666025	50666025	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agttacccattaagtgctgcGtttggttcttgacaaaggac	10	8	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:50666025G>A	uc002prp.1	-	2	365	c.278C>T	c.(277-279)ACG>ATG	p.T93M		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	93	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		TAAGTGCTGCGTTTGGTTCTT	0.567													0	0	0	0.010729	0	10	48										A	50666025	G	A	50666025	3	1	85	1	0	0	0	0	1	0	0	0	1924	1145	40	2	411	2	C19orf41	19	50666025	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	8179892	50666025	8462958	85	25507										
SHANK1	50944	broad.mit.edu	37	chr19	51165497	51165497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgagagggagcgcgaggcccCtgacaaggctcccccgagcc	15	15	0	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:51165497C>T	uc002psx.1	-	23	6230	c.6211G>A	c.(6211-6213)GGG>AGG	p.G2071R	SHANK1_uc002psw.1_Missense_Mutation_p.G1455R	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2071					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CGCGAGGCCCCTGACAAGGCT	0.692													0	0	0	0.004672	0	3	28										T	51165497	C	T	51165497	3	4	85	1	0	0	0	0	1	0	0	0	14264	681	24	2	278	2	SHANK1	19	51165497	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	499472	51165497	7963486	86	25508										
BRSK1	84446	broad.mit.edu	37	chr19	55816954	55816954	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	atcgtccatgcctttctgtcGgtgaggggcctgggtcccca	13	13	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:55816954G>C	uc002qkg.2	+	16	2167	c.1890G>C	c.(1888-1890)TCG>TCC	p.S630S	BRSK1_uc002qkf.2_Silent_p.S646S|BRSK1_uc002qkh.2_Silent_p.S325S	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	630					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCTTTCTGTCGGTGAGGGGCC	0.557													0	0	0	0.01441	0	55	162										C	55816954	G	C	55816954	2	2	85	1	0	0	0	0	0	0	0	1	1523	1130	39	4		4	BRSK1	19	55816954	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	4651457	55816954	3312029	87	25509										
MYH7B	57644	broad.mit.edu	37	chr20	33572681	33572681	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cccttgaggatcaaatcatcGaggccaaccctgccatggag	10	13	2	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr20:33572681G>C	uc002xbi.1	+	10	891	c.799G>C	c.(799-801)GAG>CAG	p.E267Q		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	225	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCAAATCATCGAGGCCAACCC	0.647													0	0	0	0.028581	0	15	50										C	33572681	G	C	33572681	3	2	85	1	0	0	0	0	1	0	0	0	10040	1059	37	1	837	1	MYH7B	20	33572681	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08		33572681	29452839	88	25510										
COL6A2	1292	broad.mit.edu	37	chr21	47531966	47531966	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gtcaccatgcagtcccccacGgacatcctgctcttccacat	6	18	2	0	rs143583433	by1000genomes	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr21:47531966G>C	uc002zia.1	+	3	271	c.189G>C	c.(187-189)ACG>ACC	p.T63T	COL6A2_uc002zhy.1_Silent_p.T63T|COL6A2_uc002zhz.1_Silent_p.T63T|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	63	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGTCCCCCACGGACATCCTGC	0.612													0	0	0	0.01892	0	25	55										C	47531966	G	C	47531966	2	2	85	1	0	0	0	0	0	0	0	1	3700	1103	39	4		4	COL6A2	21	47531966	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08		47531966	597929	89	25511										
BCL2L13	23786	broad.mit.edu	37	chr22	18210180	18210180	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	aagtctagactgtcccccgcCggtgagatgaagcccatgcc	11	14	1	3			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:18210180C>T	uc002zmw.2	+	7	1556	c.1338C>T	c.(1336-1338)GCC>GCT	p.A446A	BCL2L13_uc002zmx.2_Silent_p.A284A|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Silent_p.A284A|BCL2L13_uc011agk.1_Silent_p.A322A|BCL2L13_uc010gqz.2_Silent_p.A166A|BCL2L13_uc002zmz.2_Silent_p.A284A|BCL2L13_uc002zna.2_Silent_p.A166A	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	446	B; approximate.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		TGTCCCCCGCCGGTGAGATGA	0.612													0	0	0	0.012319	0	23	79										T	18210180	C	T	18210180	2	4	85	1	0	0	0	0	0	0	0	1	1371	639	23	2		2	BCL2L13	22	18210180	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		18210180	33094386	90	25512										
EFCAB6	64800	broad.mit.edu	37	chr22	43930620	43930620	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gcatcagtgagctttcctttGcttttagcaggaggacacag	11	9	1	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:43930620G>C	uc003bdy.1	-	30	4396	c.4181C>G	c.(4180-4182)GCA>GGA	p.A1394G	EFCAB6_uc003bdz.1_Missense_Mutation_p.A1242G|EFCAB6_uc010gzi.1_Missense_Mutation_p.A1242G	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1394	EF-hand 15.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTTTCCTTTGCTTTTAGCAG	0.473													0	0	0	0.009096	0	4	53										C	43930620	G	C	43930620	3	2	85	1	0	0	0	0	1	0	0	0	4939	1319	46	4	336	4	EFCAB6	22	43930620	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	25720440	43930620	7373946	91	25513										
CELSR1	9620	broad.mit.edu	37	chr22	46859620	46859620	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ctaccagtgaagtcctcgaaGcactcgcaggtgtagccgcc	11	14	0	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:46859620G>T	uc003bhw.1	-	2	4167	c.4167C>A	c.(4165-4167)TGC>TGA	p.C1389*		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1389	Extracellular (Potential).|EGF-like 2; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGTCCTCGAAGCACTCGCAGG	0.647													1	0	0.000602214	0.014758	0.000616006	5	10										T	46859620	G	T	46859620	4	4	85	1	0	0	0	0	0	1	0	0	3221	963	34	4	5013	4	CELSR1	22	46859620	Nonsense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	2929000	46859620	4444946	92	25514										
CELSR1	9620	broad.mit.edu	37	chr22	46859881	46859881	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	cgcaggcagatgttgtcgtcGaagggcagcacgcgctgcgt	16	11	0	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:46859881G>A	uc003bhw.1	-	2	3906	c.3906C>T	c.(3904-3906)TTC>TTT	p.F1302F		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1302	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGTTGTCGTCGAAGGGCAGCA	0.637													0	0	0	0.006214	0	10	36										A	46859881	G	A	46859881	2	1	85	1	0	0	0	0	0	0	0	1	3221	1049	37	1		1	CELSR1	22	46859881	Silent	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	261	46859881	4444685	93	25515										
FAM48B2	170067	broad.mit.edu	37	chrX	24329557	24329557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agaagatgcctgcactgcacCgggccttgcatctggtagtg	13	11	1	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:24329557C>T	uc011mjw.1	-	1	1876	c.1876G>A	c.(1876-1878)GGT>AGT	p.G626S		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	626											0						TGCACTGCACCGGGCCTTGCA	0.622													0	0	0	0.009096	0	4	31										T	24329557	C	T	24329557	3	4	85	1	0	0	0	0	1	0	0	0	5574	652	23	2	580	2	FAM48B2	23	24329557	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08		24329557	130941003	94	25516										
IL2RG	3561	broad.mit.edu	37	chrX	70331384	70331384	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	gtgaatggtaatgatggcttCaacatggcgcttgctcttca	11	8	3	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:70331384C>T	uc004dyw.1	-	1	20	c.6G>A	c.(4-6)TTG>TTA	p.L2L	IL2RG_uc004dyv.1_5'Flank|IL2RG_uc004dyx.1_5'UTR	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	2					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	ATGATGGCTTCAACATGGCGC	0.552									Severe_Combined_Immunodeficiency_X-linked				0	0	0	0.004482	0	9	18										T	70331384	C	T	70331384	2	4	85	1	0	0	0	0	0	0	0	1	7688	825	29	1		1	IL2RG	23	70331384	Silent	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	46001827	70331384	84939176	95	25517										
ATP7A	538	broad.mit.edu	37	chrX	77268496	77268496	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	ttgcctactctttgattattCttctagttgcaatgtatgag	7	7	3	2			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:77268496C>T	uc004ecx.3	+	10	2453	c.2293C>T	c.(2293-2295)CTT>TTT	p.L765F		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	765	Extracellular (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TTTGATTATTCTTCTAGTTGC	0.423													0	0	0	0.01441	0	59	61										T	77268496	C	T	77268496	3	4	85	1	0	0	0	0	1	0	0	0	1190	913	32	1	2327	1	ATP7A	23	77268496	Missense_Mutation	SNP	C	TCGA-FD-A3SQ-01A-21D-A22Z-08	6937112	77268496	78002064	96	25518										
STAG2	10735	broad.mit.edu	37	chrX	123227957	123227974	+	In_Frame_Del	DEL	ATGAGGGAATGGATTTTG	ATGAGGGAATGGATTTTG	-													0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	agggaggattgaggatcttaAtgagggaatggattttgaca							TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08			ATGAGGGAATGGATTTTG	-	ATGAGGGAATGGATTTTG	ATGAGGGAATGGATTTTG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:123227957_123227974delATGAGGGAATGGATTTTG	uc004etz.3	+	31	3896_3913	c.3557_3574delATGAGGGAATGGATTTTG	c.(3556-3576)AATGAGGGAATGGATTTTGAC>AAC	p.EGMDFD1187del	STAG2_uc004eua.2_In_Frame_Del_p.EGMDFD1224del|STAG2_uc004eub.2_In_Frame_Del_p.EGMDFD1187del|STAG2_uc004euc.2_In_Frame_Del_p.EGMDFD1224del|STAG2_uc004eud.2_In_Frame_Del_p.EGMDFD1187del|STAG2_uc004eue.2_In_Frame_Del_p.EGMDFD1187del	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1187_1192					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GAGGATCTTAATGAGGGAATGGATTTTGACACCATGGA	0.353																		10	42	---	---								-	123227974	ATGAGGGAATGGATTTTG	-	123227957	7	5	85	1	0	1	0	1	0	0	0	0	15242	101	4	0	3790	0	STAG2	23	123227957	In_Frame_Del	DEL	ATGAGGGAATGGATTTTG	TCGA-FD-A3SQ-01A-21D-A22Z-08	45959461	123227957	32042603	97	25519										
MAGEC3	139081	broad.mit.edu	37	chrX	140969332	140969332	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.23469387755102	23	7.26000212483952e-05	2.38846153846154	3.97011834319527	2.03395225464191	0.0198547218792429	0.0586616782795813	13	tgtcatcaacacatacacggGctactttcctatgatcttca	5	12	4	1			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:140969332G>A	uc011mwp.1	+	4	659	c.659G>A	c.(658-660)GGC>GAC	p.G220D		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	220	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACATACACGGGCTACTTTCCT	0.438													0	0	0	0.01441	0	56	47										A	140969332	G	A	140969332	3	1	85	1	0	0	0	0	1	0	0	0	9182	1203	42	2	673	2	MAGEC3	23	140969332	Missense_Mutation	SNP	G	TCGA-FD-A3SQ-01A-21D-A22Z-08	17741375	140969332	14301228	98	25520										
CAMTA1	23261	broad.mit.edu	37	chr1	7724545	7724545	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggcaccttcgtgatgcccacGgtgaaaacggaggcctcgtc	13	13	0	2	rs142993717		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:7724545G>A	uc001aoi.2	+	9	2145	c.1938G>A	c.(1936-1938)ACG>ACA	p.T646T		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TGATGCCCACGGTGAAAACGG	0.637													0	0	0	0.013726	0	33	161										A	7724545	G	A	7724545	2	1	86	1	0	0	0	0	0	0	0	1	2613	1103	39	2		2	CAMTA1	1	7724545	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		7724545	241526076	1	25521										
UBR4	23352	broad.mit.edu	37	chr1	19497352	19497352	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tttctcagttgttccctcttCattaaagttttgcagcaaat	5	9	3	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:19497352C>T	uc001bbi.2	-	26	3551	c.3547G>A	c.(3547-3549)GAA>AAA	p.E1183K	UBR4_uc001bbm.1_Missense_Mutation_p.E394K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1183					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTTCCCTCTTCATTAAAGTTT	0.453													0	0	0	0.01441	0	48	49										T	19497352	C	T	19497352	3	4	86	1	0	0	0	0	1	0	0	0	16901	835	29	1	12328	1	UBR4	1	19497352	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	11772807	19497352	229753269	2	25522										
EIF4G3	8672	broad.mit.edu	37	chr1	21183933	21183933	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	attttgaggggtccagtaccCgactgttcttggccccttgt	11	11	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:21183933C>T	uc001bec.2	-	20	3390	c.3134G>A	c.(3133-3135)CGG>CAG	p.R1045Q	EIF4G3_uc010odi.1_Missense_Mutation_p.R649Q|EIF4G3_uc010odj.1_Missense_Mutation_p.R1044Q|EIF4G3_uc009vpz.2_Missense_Mutation_p.R765Q|EIF4G3_uc001bed.2_Missense_Mutation_p.R1045Q|EIF4G3_uc001bef.2_Missense_Mutation_p.R1081Q|EIF4G3_uc001bee.2_Missense_Mutation_p.R1051Q	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1045					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GTCCAGTACCCGACTGTTCTT	0.463													0	0	0	0.01441	0	101	247										T	21183933	C	T	21183933	3	4	86	1	0	0	0	0	1	0	0	0	5038	652	23	2	1675	2	EIF4G3	1	21183933	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1686581	21183933	228066688	3	25523										
ARID1A	8289	broad.mit.edu	37	chr1	27059176	27059176	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcttgttgtaggagctatctCaagattcatttgggtctcag	10	7	4	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:27059176C>G	uc001bmv.1	+	4	2186	c.1813C>G	c.(1813-1815)CAA>GAA	p.Q605E	ARID1A_uc001bmt.1_Missense_Mutation_p.Q605E|ARID1A_uc001bmu.1_Missense_Mutation_p.Q605E|ARID1A_uc001bmw.1_Missense_Mutation_p.Q222E	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	605					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGAGCTATCTCAAGATTCATT	0.483			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.010729	0	12	73										G	27059176	C	G	27059176	3	3	86	1	0	0	0	0	1	0	0	0	913	827	29	1	1827	1	ARID1A	1	27059176	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	5875243	27059176	222191445	4	25524										
C1orf94	84970	broad.mit.edu	37	chr1	34663196	34663196	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acaggggccgcatcctaggtGactccaacttgcaagtcagc	11	13	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:34663196G>A	uc001bxs.3	+	2	520	c.121G>A	c.(121-123)GAC>AAC	p.D41N	C1orf94_uc001bxt.2_Missense_Mutation_p.D231N	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	41							protein binding				0		Myeloproliferative disorder(586;0.0393)				CATCCTAGGTGACTCCAACTT	0.542													0	0	0	0.016723	0	14	35										A	34663196	G	A	34663196	3	1	86	1	0	0	0	0	1	0	0	0	2071	1290	45	1	697	1	C1orf94	1	34663196	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	7604020	34663196	214587425	5	25525										
PPIE	10450	broad.mit.edu	37	chr1	40214744	40214744	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gatgatgaaaactttatcctCaagcatacgggaccaggtag	10	8	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:40214744C>G	uc001cds.1	+	8	721	c.678C>G	c.(676-678)CTC>CTG	p.L226L	PPIE_uc001cdt.1_Silent_p.L160L|PPIE_uc010oiy.1_Silent_p.L147L|PPIE_uc001cdu.1_RNA|PPIE_uc001cdv.2_Silent_p.L226L|PPIE_uc001cdw.2_Silent_p.L226L|PPIE_uc001cdx.1_Silent_p.L142L	NM_006112	NP_006103	Q9UNP9	PPIE_HUMAN	peptidylprolyl isomerase E isoform 1	226	PPIase cyclophilin-type.				protein folding|regulation of transcription, DNA-dependent	catalytic step 2 spliceosome	cyclosporin A binding|nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|protein binding|RNA binding				0	all_cancers(7;1.63e-13)|all_lung(5;2.27e-16)|all_epithelial(6;1.35e-15)|Lung NSC(20;1.49e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;2.7e-17)|all cancers(16;5.5e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ACTTTATCCTCAAGCATACGG	0.547													0	0	0	0.008871	0	16	70										G	40214744	C	G	40214744	2	3	86	1	0	0	0	0	0	0	0	1	12322	813	29	1		1	PPIE	1	40214744	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	5551548	40214744	209035877	6	25526										
TIE1	7075	broad.mit.edu	37	chr1	43778257	43778257	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cctcgccccctgcacacgtgCttctgccccccagtggtatg	9	19	1	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:43778257C>A	uc001ciu.2	+	12	1991	c.1912C>A	c.(1912-1914)CTT>ATT	p.L638I	TIE1_uc010okd.1_Missense_Mutation_p.L638I|TIE1_uc010oke.1_Missense_Mutation_p.L593I|TIE1_uc009vwq.2_Missense_Mutation_p.L594I|TIE1_uc010okf.1_Missense_Mutation_p.L283I|TIE1_uc010okg.1_Missense_Mutation_p.L283I	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	638	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGCACACGTGCTTCTGCCCCC	0.657													1	0	2.44723e-14	0.024334	2.77353e-14	24	29										A	43778257	C	A	43778257	3	1	86	1	0	0	0	0	1	0	0	0	15890	797	28	4	1958	4	TIE1	1	43778257	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	3563513	43778257	205472364	7	25527										
MTF2	22823	broad.mit.edu	37	chr1	93581036	93581036	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctctaatgtagaggggtggtGcacttaagaaaggaccaaat	12	6	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:93581036G>A	uc009wdj.2	+	6	785	c.493G>A	c.(493-495)GCA>ACA	p.A165T	MTF2_uc001dph.2_Missense_Mutation_p.A63T|MTF2_uc010oth.1_Missense_Mutation_p.A63T|MTF2_uc009wdk.2_Missense_Mutation_p.A165T|MTF2_uc001dpi.3_5'UTR|MTF2_uc010oti.1_Missense_Mutation_p.A63T|MTF2_uc001dpj.3_Missense_Mutation_p.A63T|MTF2_uc001dpl.3_Missense_Mutation_p.A63T	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	165						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		GAGGGGTGGTGCACTTAAGAA	0.393													0	0	0	0.024245	0	11	33										A	93581036	G	A	93581036	3	1	86	1	0	0	0	0	1	0	0	0	9923	1319	46	2	515	2	MTF2	1	93581036	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	49802779	93581036	155669585	8	25528										
GNAI3	2773	broad.mit.edu	37	chr1	110128959	110128959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	accttgttctggctgaggacGaggagatggtatgttggagc	16	6	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:110128959G>A	uc001dxz.2	+	6	869	c.712G>A	c.(712-714)GAG>AAG	p.E238K		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	238					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		GGCTGAGGACGAGGAGATGGT	0.413													0	0	0	0.007835	0	41	112										A	110128959	G	A	110128959	3	1	86	1	0	0	0	0	1	0	0	0	6506	1059	37	1	734	1	GNAI3	1	110128959	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	16547923	110128959	139121662	9	25529										
PIP5K1A	8394	broad.mit.edu	37	chr1	151171506	151171506	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cctccgggccgtcgtcttcgGtcggtttttcatcctttgat	10	13	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:151171506G>C	uc001exj.2	+	1	486	c.34G>C	c.(34-36)GTC>CTC	p.V12L	PIP5K1A_uc001exi.2_Missense_Mutation_p.V12L|PIP5K1A_uc010pcu.1_Missense_Mutation_p.V12L|PIP5K1A_uc001exk.2_Missense_Mutation_p.V12L	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	12					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTCGTCTTCGGTCGGTTTTTC	0.612													0	0	0	0.010771	0	44	342										C	151171506	G	C	151171506	3	2	86	1	0	0	0	0	1	0	0	0	11939	1261	44	4	36	4	PIP5K1A	1	151171506	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	41042547	151171506	98079115	10	25530										
NTRK1	4914	broad.mit.edu	37	chr1	156844786	156844786	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	caaatgtggacggagaaacaAgtttgggatcaaccgtgagt	13	6	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:156844786A>T	uc001fqh.1	+	11	1396	c.1340A>T	c.(1339-1341)AAG>ATG	p.K447M	NTRK1_uc001fqf.1_Missense_Mutation_p.K411M|NTRK1_uc009wsi.1_Missense_Mutation_p.K146M|NTRK1_uc001fqi.1_Missense_Mutation_p.K441M|NTRK1_uc009wsk.1_Missense_Mutation_p.K441M	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	447	Cytoplasmic (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CGGAGAAACAAGTTTGGGATC	0.577			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			0	0	0	0.017118	0	36	155										T	156844786	A	T	156844786	3	4	86	1	0	0	0	0	1	0	0	0	10706	72	3	5	1512	5	NTRK1	1	156844786	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	5673280	156844786	92405835	11	25531										
FMO3	2328	broad.mit.edu	37	chr1	171086520	171086520	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	agaagccttgcttctttttcCattggctgaagctctttgca	8	10	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:171086520C>T	uc001ghi.2	+	9	1648	c.1537C>T	c.(1537-1539)CAT>TAT	p.H513Y	FMO3_uc001ghh.2_Missense_Mutation_p.H513Y|FMO3_uc010pmb.1_Missense_Mutation_p.H493Y|FMO3_uc010pmc.1_Missense_Mutation_p.H450Y	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	513					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCTTTTTCCATTGGCTGAA	0.458													0	0	0	0.01441	0	62	50										T	171086520	C	T	171086520	3	4	86	1	0	0	0	0	1	0	0	0	5956	594	21	2	1567	2	FMO3	1	171086520	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	14241734	171086520	78164101	12	25532										
TNR	7143	broad.mit.edu	37	chr1	175355234	175355234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gacggcactgactgacacctCgtatcgggagccaggccgca	13	14	0	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:175355234C>T	uc001gkp.1	-	6	1792	c.1711G>A	c.(1711-1713)GAG>AAG	p.E571K	TNR_uc009wwu.1_Missense_Mutation_p.E571K	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	571	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACTGACACCTCGTATCGGGAG	0.637													0	0	0	0.016723	0	14	206										T	175355234	C	T	175355234	3	4	86	1	0	0	0	0	1	0	0	0	16335	893	31	1	2429	1	TNR	1	175355234	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	4268714	175355234	73895387	13	25533										
SEC16B	89866	broad.mit.edu	37	chr1	177927476	177927476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtcttgcattagcagctcagCgatgtcagaccccaccatgg	10	13	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:177927476C>T	uc001gli.1	-	10	1246	c.1156G>A	c.(1156-1158)GCT>ACT	p.A386T	SEC16B_uc001glk.1_Missense_Mutation_p.A63T|SEC16B_uc001glh.1_Missense_Mutation_p.A45T|SEC16B_uc009wwz.1_Missense_Mutation_p.A45T|SEC16B_uc001glj.1_Missense_Mutation_p.A387T|SEC16B_uc001gll.3_Missense_Mutation_p.A387T	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	386					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						AGCAGCTCAGCGATGTCAGAC	0.572													0	0	0	0.004482	0	9	100										T	177927476	C	T	177927476	3	4	86	1	0	0	0	0	1	0	0	0	13987	768	27	2	2094	2	SEC16B	1	177927476	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	2572242	177927476	71323145	14	25534										
LAMC1	3915	broad.mit.edu	37	chr1	183087279	183087279	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acgtgggacatacagtgagaGaagtaagttatgatataatt	11	3	0	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:183087279G>C	uc001gpy.3	+	11	2245	c.1988G>C	c.(1987-1989)AGA>ACA	p.R663T		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	663	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACAGTGAGAGAAGTAAGTTA	0.353													0	0	0	0.008291	0	11	41										C	183087279	G	C	183087279	3	2	86	1	0	0	0	0	1	0	0	0	8614	942	33	1	2030	1	LAMC1	1	183087279	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	5159803	183087279	66163342	15	25535										
PLXNA2	5362	broad.mit.edu	37	chr1	208234158	208234158	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggtcactcgcgtccctccttCcggcggtccagacaccgtca	10	18	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:208234158C>A	uc001hgz.2	-	13	3369	c.2611G>T	c.(2611-2613)GAA>TAA	p.E871*		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	871	Extracellular (Potential).|IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GTCCCTCCTTCCGGCGGTCCA	0.602													1	0	0.00887093	0.008871	0.00911464	18	29										A	208234158	C	A	208234158	4	1	86	1	0	0	0	0	0	1	0	0	12120	864	30	3	3153	3	PLXNA2	1	208234158	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	25146879	208234158	41016463	16	25536										
RGS7	6000	broad.mit.edu	37	chr1	240966262	240966262	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	atcttataaaacgtgggtatGaatcacttttcatcagtttg	7	6	4	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:240966262G>A	uc001hyv.2	-	16	1631	c.1301C>T	c.(1300-1302)TCA>TTA	p.S434L	RGS7_uc010pyh.1_Missense_Mutation_p.S408L|RGS7_uc010pyj.1_Missense_Mutation_p.S350L|RGS7_uc001hyu.2_Missense_Mutation_p.S434L|RGS7_uc009xgn.1_Missense_Mutation_p.S381L|RGS7_uc001hyw.2_Missense_Mutation_p.S434L|RGS7_uc001hyt.2_Missense_Mutation_p.S266L	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	434	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			ACGTGGGTATGAATCACTTTT	0.358													0	0	0	0.016522	0	23	94										A	240966262	G	A	240966262	3	1	86	1	0	0	0	0	1	0	0	0	13310	1294	45	1	174	1	RGS7	1	240966262	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	32732104	240966262	8284359	17	25537										
OR14C36	127066	broad.mit.edu	37	chr1	248512486	248512486	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccctgtgatcgtgaactctcGaatctgcatccagatgacac	8	13	2	4	rs142744958		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:248512486G>C	uc010pzl.1	+	1	410	c.410G>C	c.(409-411)CGA>CCA	p.R137P		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTGAACTCTCGAATCTGCATC	0.512													0	0	0	0.016723	0	12	102										C	248512486	G	C	248512486	3	2	86	1	0	0	0	0	1	0	0	0	10946	1058	37	1	412	1	OR14C36	1	248512486	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	7546224	248512486	738135	18	25538										
OR2T3	343173	broad.mit.edu	37	chr1	248637272	248637272	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aagacgctcatgtacctgtgCtgcatcctcatgcttctcgc	8	14	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr1:248637272C>T	uc001iel.1	+	1	621	c.621C>T	c.(619-621)TGC>TGT	p.C207C		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTACCTGTGCTGCATCCTCA	0.537													0	0	0	0.01441	0	276	140										T	248637272	C	T	248637272	2	4	86	1	0	0	0	0	0	0	0	1	11023	805	28	2		2	OR2T3	1	248637272	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	124786	248637272	613349	19	25539										
PIGF	5281	broad.mit.edu	37	chr2	46840834	46840834	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtaaaaatttcaaacttactCtatcagtggtgctccataca	5	9	3	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:46840834C>G	uc002rvd.2	-	3	483	c.319G>C	c.(319-321)GAG>CAG	p.E107Q	PIGF_uc002rvc.2_Missense_Mutation_p.E107Q	NM_002643	NP_002634	Q07326	PIGF_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	107					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	ethanolaminephosphotransferase activity				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CAAACTTACTCTATCAGTGGT	0.303													0	0	0	0.009096	0	4	15										G	46840834	C	G	46840834	3	3	86	1	0	0	0	0	1	0	0	0	11887	927	32	1	435	1	PIGF	2	46840834	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		46840834	196358539	20	25540										
PIGF	5281	broad.mit.edu	37	chr2	46842192	46842192	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	caaccatgtcaagtgtgtttCcaatattgagaagttctcca	7	9	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:46842192C>G	uc002rvd.2	-	2	276	c.112G>C	c.(112-114)GAA>CAA	p.E38Q	PIGF_uc002rvc.2_Missense_Mutation_p.E38Q|CRIPT_uc002rve.2_5'Flank	NM_002643	NP_002634	Q07326	PIGF_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	38					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	ethanolaminephosphotransferase activity				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			AAGTGTGTTTCCAATATTGAG	0.348													0	0	0	0.008871	0	20	118										G	46842192	C	G	46842192	3	3	86	1	0	0	0	0	1	0	0	0	11887	864	30	1	646	1	PIGF	2	46842192	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1358	46842192	196357181	21	25541										
PELI1	57162	broad.mit.edu	37	chr2	64322381	64322381	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aattaacgagccatcttgtaActgattggtttcaatttcca	6	8	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:64322381A>C	uc002scs.3	-	6	4751	c.712T>G	c.(712-714)TTA>GTA	p.L238V	PELI1_uc002sct.3_Missense_Mutation_p.L238V|PELI1_uc002scr.3_Missense_Mutation_p.L59V	NM_020651	NP_065702	Q96FA3	PELI1_HUMAN	pellino protein	238					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1						CCATCTTGTAACTGATTGGTT	0.398													0	0	0	0.01892	0	25	43										C	64322381	A	C	64322381	3	2	86	1	0	0	0	0	1	0	0	0	11721	40	2	5	548	5	PELI1	2	64322381	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	17480189	64322381	178876992	22	25542										
RETSAT	54884	broad.mit.edu	37	chr2	85570773	85570773	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgagtatacctgtcagatagAggttggggatggggctctgg	17	5	2	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:85570773A>T	uc002spd.2	-	10	1873	c.1682T>A	c.(1681-1683)CTC>CAC	p.L561H	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.L500H|RETSAT_uc010fgf.2_Missense_Mutation_p.L352H	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	561					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	TGTCAGATAGAGGTTGGGGAT	0.647													0	0	0	0.016522	0	21	36										T	85570773	A	T	85570773	3	4	86	1	0	0	0	0	1	0	0	0	13238	304	11	5	158	5	RETSAT	2	85570773	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	21248392	85570773	157628600	23	25543										
FHL2	2274	broad.mit.edu	37	chr2	105979821	105979821	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aggcagtaggcaaagtcatcGcgagctgtgaagcgctgccc	14	11	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:105979821G>A	uc002tcu.2	-	5	946	c.609C>T	c.(607-609)CGC>CGT	p.R203R	FHL2_uc002tdc.2_Silent_p.R89R|FHL2_uc002tdd.2_Silent_p.R203R|FHL2_uc002tct.2_Silent_p.R89R|FHL2_uc002tcv.2_Silent_p.R203R|FHL2_uc002tcw.2_Silent_p.R203R|FHL2_uc002tcx.2_Silent_p.R203R|FHL2_uc010fje.2_Silent_p.R116R|FHL2_uc002tcy.2_Silent_p.R203R|FHL2_uc002tcz.2_Silent_p.R313R|FHL2_uc002tda.2_RNA|FHL2_uc002tdb.2_Silent_p.R319R	NM_201557	NP_963851	Q14192	FHL2_HUMAN	four and a half LIM domains 2	203	LIM zinc-binding 3.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			ovary(1)	1						CAAAGTCATCGCGAGCTGTGA	0.612													0	0	0	0.009096	0	4	13										A	105979821	G	A	105979821	2	1	86	1	0	0	0	0	0	0	0	1	5879	1074	38	2		2	FHL2	2	105979821	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	20409048	105979821	137219552	24	25544										
CCDC138	165055	broad.mit.edu	37	chr2	109403310	109403310	+	Frame_Shift_Del	DEL	A	A	-													0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggtcgtcaagccaccggggcAggatttagtagtggagagtc							TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:109403310delA	uc002ten.1	+	1	92	c.32delA	c.(31-33)CAGfs	p.Q11fs	CCDC138_uc002teo.1_Frame_Shift_Del_p.Q11fs|CCDC138_uc002tep.1_5'UTR|CCDC138_uc010fjm.1_5'UTR	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	11											0						CCACCGGGGCAGGATTTAGTA	0.667																		2	4	---	---								-	109403310	A	-	109403310	7	5	86	1	0	1	0	1	0	0	0	0	2772	188	7	0	34	0	CCDC138	2	109403310	Frame_Shift_Del	DEL	A	TCGA-FD-A3SR-01A-11D-A22Z-08	3423489	109403310	133796063	25	25545										
GLI2	2736	broad.mit.edu	37	chr2	121747574	121747574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aaacaggcccgatgggggtgGctacagcaggctttggccta	15	10	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:121747574G>A	uc010flp.2	+	13	4114	c.4084G>A	c.(4084-4086)GCT>ACT	p.A1362T	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Missense_Mutation_p.A1034T|GLI2_uc002tmu.3_Missense_Mutation_p.A1017T	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1362					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GATGGGGGTGGCTACAGCAGG	0.697													0	0	0	0.009096	0	4	7										A	121747574	G	A	121747574	3	1	86	1	0	0	0	0	1	0	0	0	6438	1203	42	2	4134	2	GLI2	2	121747574	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	12344264	121747574	121451799	26	25546										
PDE11A	50940	broad.mit.edu	37	chr2	178936981	178936981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acctctgcaggtgctgtgagCcaagctgctggtaccagcca	12	13	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr2:178936981C>T	uc002ulq.2	-	1	502	c.184G>A	c.(184-186)GCT>ACT	p.A62T	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	62					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GTGCTGTGAGCCAAGCTGCTG	0.627									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.004482	0	9	16										T	178936981	C	T	178936981	3	4	86	1	0	0	0	0	1	0	0	0	11631	739	26	2	2697	2	PDE11A	2	178936981	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	57189407	178936981	64262392	27	25547										
HACL1	26061	broad.mit.edu	37	chr3	15621475	15621475	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	agggacaacacccttccccaTaggggtgggcaaaaatggca	12	11	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:15621475T>C	uc003caf.2	-	9	905	c.745A>G	c.(745-747)ATG>GTG	p.M249V	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.M222V|HACL1_uc011avt.1_Missense_Mutation_p.M223V|HACL1_uc003cag.2_5'UTR|HACL1_uc011avu.1_Missense_Mutation_p.M167V|HACL1_uc010hep.2_Intron	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	249					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0						CCCTTCCCCATAGGGGTGGGC	0.443													0	0	0	0.015359	0	36	55										C	15621475	T	C	15621475	3	2	86	1	0	0	0	0	1	0	0	0	6941	1406	49	5	1027	5	HACL1	3	15621475	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08		15621475	182400955	28	25548										
GALNTL2	117248	broad.mit.edu	37	chr3	16268952	16268952	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtacctgcgtccgtgtgatgGaaaagcccgccagcagtggc	14	12	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:16268952G>T	uc003car.3	+	10	2340	c.1865G>T	c.(1864-1866)GGA>GTA	p.G622V	GALNTL2_uc003caq.3_Missense_Mutation_p.G355V|GALNTL2_uc003cas.3_Missense_Mutation_p.G152V	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	622	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						CCGTGTGATGGAAAAGCCCGC	0.428													1	0	1.10513e-12	0.014323	1.23012e-12	19	30										T	16268952	G	T	16268952	3	4	86	1	0	0	0	0	1	0	0	0	6222	1174	41	3	1903	3	GALNTL2	3	16268952	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	647477	16268952	181753478	29	25549										
ZNF35	7584	broad.mit.edu	37	chr3	44692638	44692638	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aaaaggaggaggaagaagaaGaaaacttcccaggtcaggca	13	6	1	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:44692638G>A	uc003cnq.2	+	2	300	c.79G>A	c.(79-81)GAA>AAA	p.E27K	ZNF35_uc003cnr.2_5'UTR	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	27	Globular domain.|Poly-Glu.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		GGAAGAAGAAGAAAACTTCCC	0.542													0	0	0	0.006214	0	10	55										A	44692638	G	A	44692638	3	1	86	1	0	0	0	0	1	0	0	0	17859	943	33	1	81	1	ZNF35	3	44692638	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	28423686	44692638	153329792	30	25550										
ZNF35	7584	broad.mit.edu	37	chr3	44692740	44692740	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	caggccttgatggatcagaaGaggaagaaaaggtaaacggg	15	5	1	4			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:44692740G>C	uc003cnq.2	+	2	402	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	ZNF35_uc003cnr.2_5'UTR	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	61	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		TGGATCAGAAGAGGAAGAAAA	0.537													0	0	0	0.014758	0	5	38										C	44692740	G	C	44692740	3	2	86	1	0	0	0	0	1	0	0	0	17859	943	33	1	183	1	ZNF35	3	44692740	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	102	44692740	153329690	31	25551										
TDGF1	6997	broad.mit.edu	37	chr3	46621463	46621463	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	actgtgggtctgtgccccatGacacctggctgcccaagaag	12	13	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:46621463G>C	uc003cpv.2	+	5	641	c.361G>C	c.(361-363)GAC>CAC	p.D121H	LRRC2_uc003cpu.3_5'UTR	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	121					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TGTGCCCCATGACACCTGGCT	0.557													0	0	0	0.010729	0	12	49										C	46621463	G	C	46621463	3	2	86	1	0	0	0	0	1	0	0	0	15723	1290	45	1	379	1	TDGF1	3	46621463	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1928723	46621463	151400967	32	25552										
COL7A1	1294	broad.mit.edu	37	chr3	48623896	48623896	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccaacatgtatctgtgagctGtgaccacggctgtgcctgga	12	11	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:48623896G>C	uc003ctz.2	-	26	3420	c.3419C>G	c.(3418-3420)ACA>AGA	p.T1140R		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1140	Nonhelical region (NC1).|VWFA 2.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTGTGAGCTGTGACCACGGC	0.592													0	0	0	0.01441	0	67	95										C	48623896	G	C	48623896	3	2	86	1	0	0	0	0	1	0	0	0	3704	1377	48	4	5787	4	COL7A1	3	48623896	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	2002433	48623896	149398534	33	25553										
HYAL2	8692	broad.mit.edu	37	chr3	50357493	50357493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	catctttgtcctgccagttgCgcacccacacaggtcgccag	9	16	1	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:50357493C>T	uc003czu.2	-	2	648	c.428G>A	c.(427-429)CGC>CAC	p.R143H	HYAL2_uc003czx.2_Missense_Mutation_p.R143H|HYAL2_uc003czv.2_Missense_Mutation_p.R143H|HYAL2_uc003czw.2_Missense_Mutation_p.R143H|HYAL2_uc010hlj.2_Missense_Mutation_p.R143H	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor	143						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	CTGCCAGTTGCGCACCCACAC	0.592													0	0	0	0.010504	0	21	98										T	50357493	C	T	50357493	3	4	86	1	0	0	0	0	1	0	0	0	7464	768	27	2	1005	2	HYAL2	3	50357493	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1733597	50357493	147664937	34	25554										
GRM2	2912	broad.mit.edu	37	chr3	51747292	51747292	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccagttaacgggcgccgcctCtacaaggactttgtgctcaa	10	13	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:51747292C>G	uc010hlv.2	+	3	1493	c.1254C>G	c.(1252-1254)CTC>CTG	p.L418L	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	418	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGCGCCGCCTCTACAAGGACT	0.587													0	0	0	0.004482	0	9	19										G	51747292	C	G	51747292	2	3	86	1	0	0	0	0	0	0	0	1	6797	900	32	1		1	GRM2	3	51747292	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1389799	51747292	146275138	35	25555										
ALAS1	211	broad.mit.edu	37	chr3	52248035	52248035	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttaaaaactgtttctcctcaGagaatctgctagtcacatgg	7	9	4	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:52248035G>C	uc003dcy.1	+	12	2100	c.1763_splice	c.e12-1	p.E588_splice	ALAS1_uc003dcz.1_Splice_Site_p.E588_splice|ALAS1_uc011bec.1_Splice_Site_p.E605_splice	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor						heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTTCTCCTCAGAGAATCTGCT	0.303													0	0	0	0.010729	0	11	46										C	52248035	G	C	52248035	5	2	86	1	0	0	0	0	0	0	1	0	484	956	33	1	1800	1	ALAS1	3	52248035	Splice_Site	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	500743	52248035	145774395	36	25556										
PLXND1	23129	broad.mit.edu	37	chr3	129304863	129304863	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aggacagcggctggggccctCgctggcactggtccagaaat	15	12	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:129304863C>T	uc003emx.2	-	5	1883	c.1783G>A	c.(1783-1785)GAG>AAG	p.E595K		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	595	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CTGGGGCCCTCGCTGGCACTG	0.657													0	0	0	0.016522	0	24	94										T	129304863	C	T	129304863	3	4	86	1	0	0	0	0	1	0	0	0	12127	893	31	1	4122	1	PLXND1	3	129304863	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	77056828	129304863	68717567	37	25557										
NDUFB5	4711	broad.mit.edu	37	chr3	179322629	179322629	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggccatgagtttgttgcggcGggtttcggttactgcggtgg	18	7	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr3:179322629G>T	uc003fkc.2	+	1	55	c.26G>T	c.(25-27)CGG>CTG	p.R9L	MRPL47_uc003fjz.2_5'Flank|MRPL47_uc003fka.2_5'Flank|MRPL47_uc003fkb.2_5'Flank|NDUFB5_uc003fkd.2_RNA|NDUFB5_uc003fke.2_Missense_Mutation_p.R9L	NM_002492	NP_002483	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	9					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	TTGTTGCGGCGGGTTTCGGTT	0.607													1	0	0.00621372	0.006214	0.0064197	9	37										T	179322629	G	T	179322629	3	4	86	1	0	0	0	0	1	0	0	0	10284	1116	39	4	28	4	NDUFB5	3	179322629	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	50017766	179322629	18699801	38	25558										
WHSC2	7469	broad.mit.edu	37	chr4	1985773	1985773	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggcgcccgctgcttgaactgCgctggcaacgtggggctcgg	17	13	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:1985773C>T	uc003gem.2	-	9	1377	c.1137G>A	c.(1135-1137)GCG>GCA	p.A379A	WHSC2_uc003gek.2_Silent_p.A105A|WHSC2_uc003gel.2_Silent_p.A293A|WHSC2_uc003gen.2_Silent_p.A233A	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	368					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GCTTGAACTGCGCTGGCAACG	0.716													0	0	0	0.009096	0	4	14										T	1985773	C	T	1985773	2	4	86	1	0	0	0	0	0	0	0	1	17361	755	27	2		2	WHSC2	4	1985773	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		1985773	189168503	39	25559										
RGS12	6002	broad.mit.edu	37	chr4	3319746	3319746	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aaagcatttttggtccccatCgaaatgttcgaaagactaag	8	8	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:3319746C>T	uc003ggw.2	+	2	2753	c.1849C>T	c.(1849-1851)CGA>TGA	p.R617*	RGS12_uc003ggu.2_Nonsense_Mutation_p.R617*|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Nonsense_Mutation_p.R617*|RGS12_uc003ggx.1_Nonsense_Mutation_p.R617*	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	617						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGGTCCCCATCGAAATGTTCG	0.582													0	0	0	0.021523	0	27	107										T	3319746	C	T	3319746	4	4	86	1	0	0	0	0	0	1	0	0	13295	876	31	1	1851	1	RGS12	4	3319746	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1333973	3319746	187834530	40	25560										
EVC2	132884	broad.mit.edu	37	chr4	5570351	5570351	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tggccatcctcgccaggtacGatgccagtctcagctcctac	9	16	1	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:5570351G>A	uc003gij.2	-	20	3431	c.3377C>T	c.(3376-3378)TCG>TTG	p.S1126L	EVC2_uc011bwb.1_Missense_Mutation_p.S566L|EVC2_uc003gik.2_Missense_Mutation_p.S1046L	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1126						integral to membrane				large_intestine(3)|ovary(2)	5						CGCCAGGTACGATGCCAGTCT	0.577													0	0	0	0.00308	0	6	11										A	5570351	G	A	5570351	3	1	86	1	0	0	0	0	1	0	0	0	5286	1059	37	1	561	1	EVC2	4	5570351	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	2250605	5570351	185583925	41	25561										
NIPAL1	152519	broad.mit.edu	37	chr4	48035086	48035086	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtcacccctctgggtgctttGagtgttctcataaggtatgt	11	9	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:48035086G>C	uc003gxw.2	+	4	513	c.447G>C	c.(445-447)TTG>TTC	p.L149F		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	149	Helical; (Potential).					integral to membrane					0						TGGGTGCTTTGAGTGTTCTCA	0.428													0	0	0	0.013537	0	13	43										C	48035086	G	C	48035086	3	2	86	1	0	0	0	0	1	0	0	0	10424	1281	45	1	461	1	NIPAL1	4	48035086	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	42464735	48035086	143119190	42	25562										
NHEDC1	150159	broad.mit.edu	37	chr4	103867833	103867833	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gagtccaagcccagctcttaTtagaataatggtaagggcaa	10	8	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:103867833T>C	uc003hww.2	-	5	618	c.496A>G	c.(496-498)ATA>GTA	p.I166V	NHEDC1_uc003hwu.2_Missense_Mutation_p.I166V|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	166	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		CCAGCTCTTATTAGAATAATG	0.363													0	0	0	0.011902	0	45	41										C	103867833	T	C	103867833	3	2	86	1	0	0	0	0	1	0	0	0	10400	1493	52	5	1183	5	NHEDC1	4	103867833	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	55832747	103867833	87286443	43	25563										
UGT8	7368	broad.mit.edu	37	chr4	115544466	115544466	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tggaccctaatgatatgtgtGgatttgtgatagctcatctt	10	6	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:115544466G>A	uc003ibs.2	+	2	952	c.430G>A	c.(430-432)GGA>AGA	p.G144R	UGT8_uc003ibt.2_Missense_Mutation_p.G144R|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	144					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TGATATGTGTGGATTTGTGAT	0.448													0	0	0	0.01441	0	49	97										A	115544466	G	A	115544466	3	1	86	1	0	0	0	0	1	0	0	0	16962	1349	47	2	432	2	UGT8	4	115544466	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	11676633	115544466	75609810	44	25564										
INPP4B	8821	broad.mit.edu	37	chr4	143003291	143003291	+	Frame_Shift_Del	DEL	G	G	-													0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gacatcgatgtcctgtctttGgcacttttacaacaggtgaa							TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:143003291delG	uc003iix.3	-	26	3130	c.2535delC	c.(2533-2535)GCCfs	p.A845fs	INPP4B_uc003iiw.3_Frame_Shift_Del_p.A845fs|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Frame_Shift_Del_p.A660fs|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	845					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TCCTGTCTTTGGCACTTTTAC	0.408																		26	53	---	---								-	143003291	G	-	143003291	7	5	86	1	0	1	0	1	0	0	0	0	7753	1335	47	0	247	0	INPP4B	4	143003291	Frame_Shift_Del	DEL	G	TCGA-FD-A3SR-01A-11D-A22Z-08	27458825	143003291	48150985	45	25565										
HHIP	64399	broad.mit.edu	37	chr4	145573799	145573799	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cagaatgtgggaagttactgGaggaaatcaaatgtgcactt	12	5	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:145573799G>C	uc003ijs.1	+	2	977	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	HHIP_uc003ijr.1_Missense_Mutation_p.E108Q	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	108						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GAAGTTACTGGAGGAAATCAA	0.393													0	0	0	0.007413	0	19	92										C	145573799	G	C	145573799	3	2	86	1	0	0	0	0	1	0	0	0	7092	1175	41	1	328	1	HHIP	4	145573799	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	2570508	145573799	45580477	46	25566										
HHIP	64399	broad.mit.edu	37	chr4	145635380	145635380	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gctatgtttctttccagaaaGtgagccatcacttttagaat	7	8	2	3	rs147064425		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:145635380G>A	uc003ijs.1	+	9	2082	c.1427G>A	c.(1426-1428)AGT>AAT	p.S476N		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	476						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TTTCCAGAAAGTGAGCCATCA	0.353													0	0	0	0.008291	0	10	34										A	145635380	G	A	145635380	3	1	86	1	0	0	0	0	1	0	0	0	7092	1029	36	2	1461	2	HHIP	4	145635380	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	61581	145635380	45518896	47	25567										
NPY5R	4889	broad.mit.edu	37	chr4	164271826	164271826	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttcaactttaattttaatatCaattgccattgtcaggtatc	4	7	3	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:164271826C>T	uc003iqn.2	+	4	583	c.401C>T	c.(400-402)TCA>TTA	p.S134L		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	134	Helical; Name=3; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ATTTTAATATCAATTGCCATT	0.358													0	0	0	0.025465	0	42	159										T	164271826	C	T	164271826	3	4	86	1	0	0	0	0	1	0	0	0	10610	838	29	1	403	1	NPY5R	4	164271826	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	18636446	164271826	26882450	48	25568										
CLCN3	1182	broad.mit.edu	37	chr4	170608906	170608906	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aacactaacaggattggcatCaggtaaagaaaatttttcaa	7	6	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:170608906C>A	uc003isi.2	+	4	925	c.416C>A	c.(415-417)TCA>TAA	p.S139*	CLCN3_uc003ish.2_Nonsense_Mutation_p.S139*|CLCN3_uc011cjz.1_Nonsense_Mutation_p.S122*|CLCN3_uc011cka.1_Nonsense_Mutation_p.S139*|CLCN3_uc003isj.1_Nonsense_Mutation_p.S112*	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	139	Helical; (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GGATTGGCATCAGGTAAAGAA	0.358													1	0	4.84862e-15	0.010729	5.5286e-15	12	62										A	170608906	C	A	170608906	4	1	86	1	0	0	0	0	0	1	0	0	3464	838	29	3	426	3	CLCN3	4	170608906	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	6337080	170608906	20545370	49	25569										
GALNTL6	442117	broad.mit.edu	37	chr4	173961175	173961175	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggccagatgtgaccctctctCtgagactcagcagtggattt	11	11	3	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr4:173961175C>T	uc003isv.2	+	13	2466	c.1730C>T	c.(1729-1731)TCT>TTT	p.S577F		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	577	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GACCCTCTCTCTGAGACTCAG	0.428													0	0	0	0.024245	0	16	71										T	173961175	C	T	173961175	3	4	86	1	0	0	0	0	1	0	0	0	6225	913	32	1	1776	1	GALNTL6	4	173961175	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	3352269	173961175	17193101	50	25570										
CDH18	1016	broad.mit.edu	37	chr5	19571845	19571845	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gatcttcagcatagtagcatCtttaaaaggacccaagtgag	9	8	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:19571845C>G	uc003jgc.2	-	7	1473	c.1096G>C	c.(1096-1098)GAT>CAT	p.D366H	CDH18_uc003jgd.2_Missense_Mutation_p.D366H|CDH18_uc011cnm.1_Missense_Mutation_p.D366H	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	366	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATAGTAGCATCTTTAAAAGGA	0.403													0	0	0	0.006122	0	19	55										G	19571845	C	G	19571845	3	3	86	1	0	0	0	0	1	0	0	0	3103	913	32	1	1300	1	CDH18	5	19571845	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		19571845	161343415	51	25571										
GHR	2690	broad.mit.edu	37	chr5	42718627	42718627	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aacccgaattccacagtgatGactcttgggttgaatttatt	8	8	1	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:42718627G>A	uc003jmt.2	+	10	1061	c.1018G>A	c.(1018-1020)GAC>AAC	p.D340N	GHR_uc011cpq.1_Missense_Mutation_p.D153N	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	340	Cytoplasmic (Potential).|UbE motif.				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CCACAGTGATGACTCTTGGGT	0.378													0	0	0	0.01441	0	130	143										A	42718627	G	A	42718627	3	1	86	1	0	0	0	0	1	0	0	0	6371	1290	45	1	1052	1	GHR	5	42718627	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	23146782	42718627	138196633	52	25572										
CWC27	10283	broad.mit.edu	37	chr5	64100077	64100077	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	atggagaagatgaaagtgcaGagcatgatgaatatattgat	12	2	0	7			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:64100077G>C	uc003jtn.1	+	10	1021	c.802G>C	c.(802-804)GAG>CAG	p.E268Q	CWC27_uc003jtl.2_Missense_Mutation_p.E268Q|CWC27_uc003jtm.2_Missense_Mutation_p.E268Q|CWC27_uc010iwt.1_Missense_Mutation_p.E268Q	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	268					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						TGAAAGTGCAGAGCATGATGA	0.368													0	0	0	0.028581	0	16	31										C	64100077	G	C	64100077	3	2	86	1	0	0	0	0	1	0	0	0	4070	943	33	1	840	1	CWC27	5	64100077	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	21381450	64100077	116815183	53	25573										
F2RL1	2150	broad.mit.edu	37	chr5	76128611	76128611	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tacagttgaaacagtcttttCtgtggatgagttttctgcat	9	6	3	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:76128611C>G	uc003keo.2	+	2	354	c.179C>G	c.(178-180)TCT>TGT	p.S60C		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	60	Extracellular (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		ACAGTCTTTTCTGTGGATGAG	0.438													0	0	0	0.012213	0	32	71										G	76128611	C	G	76128611	3	3	86	1	0	0	0	0	1	0	0	0	5344	913	32	1	185	1	F2RL1	5	76128611	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	12028534	76128611	104786649	54	25574										
ZCCHC9	84240	broad.mit.edu	37	chr5	80600669	80600669	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aagaagggatcctttgagggAacaagccaaaacctaccaaa	9	9	0	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:80600669A>C	uc003khj.2	+	2	226	c.93A>C	c.(91-93)GGA>GGC	p.G31G	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Silent_p.G31G|ZCCHC9_uc003khi.2_Silent_p.G31G	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	31							nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		CCTTTGAGGGAACAAGCCAAA	0.423													0	0	0	0.012319	0	22	50										C	80600669	A	C	80600669	2	2	86	1	0	0	0	0	0	0	0	1	17592	233	9	5		5	ZCCHC9	5	80600669	Silent	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	4472058	80600669	100314591	55	25575										
DCP2	167227	broad.mit.edu	37	chr5	112327847	112327847	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	attgtccgtttttgctgcctCaaggtgaagatgtggaaaaa	11	6	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:112327847C>G	uc003kqh.2	+	3	433	c.235C>G	c.(235-237)CAA>GAA	p.Q79E	DCP2_uc011cwa.1_Intron|DCP2_uc010jcc.2_5'UTR	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	79					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		TTTGCTGCCTCAAGGTGAAGA	0.353													0	0	0	0.014323	0	19	82										G	112327847	C	G	112327847	3	3	86	1	0	0	0	0	1	0	0	0	4300	827	29	1	245	1	DCP2	5	112327847	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	31727178	112327847	68587413	56	25576										
KCNN2	3781	broad.mit.edu	37	chr5	113698511	113698511	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aacgggggcgtcatgcggccGctcagcaacttgagcgcgtc	15	13	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr5:113698511G>A	uc003kqo.2	+	1	496	c.39G>A	c.(37-39)CCG>CCA	p.P13P		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	13						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TCATGCGGCCGCTCAGCAACT	0.607													0	0	0	0.004482	0	8	6										A	113698511	G	A	113698511	2	1	86	1	0	0	0	0	0	0	0	1	8079	1074	38	2		2	KCNN2	5	113698511	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1370664	113698511	67216749	57	25577										
ZBTB22	9278	broad.mit.edu	37	chr6	33284496	33284496	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gcccgatgagcccggaactcCcggccctgcactctgataga	11	16	1	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:33284496C>T	uc003oeb.2	-	2	350	c.198G>A	c.(196-198)CGG>CGA	p.R66R	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.R66R	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	66	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCCGGAACTCCCGGCCCTGCA	0.592													0	0	0	0.01441	0	48	70										T	33284496	C	T	33284496	2	4	86	1	0	0	0	0	0	0	0	1	17527	610	22	2		2	ZBTB22	6	33284496	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		33284496	137830571	58	25578										
BRPF3	27154	broad.mit.edu	37	chr6	36168155	36168155	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cgagggccggcgttccccgtCcccctacagtctcaagtgct	11	17	1	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:36168155C>T	uc003olv.3	+	2	280	c.56C>T	c.(55-57)TCC>TTC	p.S19F	BRPF3_uc010jwb.2_Missense_Mutation_p.S19F|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Missense_Mutation_p.S19F	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	19					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CGTTCCCCGTCCCCCTACAGT	0.627													0	0	0	0.021553	0	6	75										T	36168155	C	T	36168155	3	4	86	1	0	0	0	0	1	0	0	0	1521	855	30	1	58	1	BRPF3	6	36168155	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	2883659	36168155	134946912	59	25579										
MDGA1	266727	broad.mit.edu	37	chr6	37622222	37622222	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgggaccactgcagctggggGaggggatcaccgcctgtcag	17	11	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:37622222G>T	uc003onu.1	-	6	1989	c.810C>A	c.(808-810)CTC>CTA	p.L270L	MDGA1_uc003onw.3_5'Flank	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	270	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						GCAGCTGGGGGAGGGGATCAC	0.647													1	0	7.45023e-12	0.010504	8.19525e-12	22	41										T	37622222	G	T	37622222	2	4	86	1	0	0	0	0	0	0	0	1	9406	1161	41	3		3	MDGA1	6	37622222	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1454067	37622222	133492845	60	25580										
MDGA1	266727	broad.mit.edu	37	chr6	37622284	37622284	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctccccagggttcaccaccaGagtttcgttcacagacagct	8	15	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:37622284G>C	uc003onu.1	-	6	1927	c.748C>G	c.(748-750)CTG>GTG	p.L250V	MDGA1_uc003onw.3_5'Flank	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	250	Ig-like 3.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						TTCACCACCAGAGTTTCGTTC	0.617													0	0	0	0.010771	0	43	78										C	37622284	G	C	37622284	3	2	86	1	0	0	0	0	1	0	0	0	9406	933	33	1	2167	1	MDGA1	6	37622284	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	62	37622284	133492783	61	25581										
TREM1	54210	broad.mit.edu	37	chr6	41254347	41254347	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcctcttccttgtcttacctGagacaaagagcatccacagc	6	14	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:41254347G>A	uc003oqf.1	-	1	111	c.47C>T	c.(46-48)TCA>TTA	p.S16L	TREM1_uc003oqg.1_Missense_Mutation_p.S16L	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	16					blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	TGTCTTACCTGAGACAAAGAG	0.577													0	0	0	0.006214	0	10	79										A	41254347	G	A	41254347	3	1	86	1	0	0	0	0	1	0	0	0	16467	1294	45	1	673	1	TREM1	6	41254347	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	3632063	41254347	129860720	62	25582										
TDRD6	221400	broad.mit.edu	37	chr6	46660807	46660807	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tttcagaaggattatgttctCaagagggaaatgactatttc	9	5	2	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:46660807C>G	uc003oyj.2	+	1	4942	c.4942C>G	c.(4942-4944)CAA>GAA	p.Q1648E	TDRD6_uc010jze.2_Missense_Mutation_p.Q1642E	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1648					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			ATTATGTTCTCAAGAGGGAAA	0.383													0	0	0	0.020292	0	14	104										G	46660807	C	G	46660807	3	3	86	1	0	0	0	0	1	0	0	0	15731	827	29	1	4944	1	TDRD6	6	46660807	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	5406460	46660807	124454260	63	25583										
DST	667	broad.mit.edu	37	chr6	56391242	56391242	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	taatcggtagcgctcattgtCctcagctaccattttctcaa	6	12	3	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:56391242C>T	uc003pdf.2	-	63	11717	c.11689G>A	c.(11689-11691)GAC>AAC	p.D3897N	DST_uc003pcz.3_Missense_Mutation_p.D3719N|DST_uc011dxj.1_Missense_Mutation_p.D3748N|DST_uc011dxk.1_Missense_Mutation_p.D3759N|DST_uc003pcy.3_Missense_Mutation_p.D3393N	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5805					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGCTCATTGTCCTCAGCTACC	0.493													0	0	0	0.013726	0	35	127										T	56391242	C	T	56391242	3	4	86	1	0	0	0	0	1	0	0	0	4783	855	30	1	5478	1	DST	6	56391242	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	9730435	56391242	114723825	64	25584										
DST	667	broad.mit.edu	37	chr6	56420230	56420230	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	caagtactcttctttaaccaGtgctgacaaatcctcacaga	5	12	3	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:56420230G>T	uc003pdf.2	-	54	8720	c.8692C>A	c.(8692-8694)CTG>ATG	p.L2898M	DST_uc003pcz.3_Missense_Mutation_p.L2720M|DST_uc011dxj.1_Missense_Mutation_p.L2749M|DST_uc011dxk.1_Missense_Mutation_p.L2760M|DST_uc003pcy.3_Missense_Mutation_p.L2394M	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4806					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTTTAACCAGTGCTGACAAA	0.408													1	0	4.11147e-13	0.017118	4.60387e-13	33	70										T	56420230	G	T	56420230	3	4	86	1	0	0	0	0	1	0	0	0	4783	1020	36	4	8511	4	DST	6	56420230	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	28988	56420230	114694837	65	25585										
ZNF451	26036	broad.mit.edu	37	chr6	57012841	57012841	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	taagatagaaacattgtaccGacattgccaagatgagcatg	9	7	0	4			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:57012841G>C	uc003pdm.1	+	10	2182	c.1958G>C	c.(1957-1959)CGA>CCA	p.R653P	ZNF451_uc003pdl.2_Missense_Mutation_p.R653P|ZNF451_uc003pdn.1_Missense_Mutation_p.R653P|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.R653P	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	653	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ACATTGTACCGACATTGCCAA	0.373													0	0	0	0.01441	0	57	84										C	57012841	G	C	57012841	3	2	86	1	0	0	0	0	1	0	0	0	17919	1058	37	1	1996	1	ZNF451	6	57012841	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	592611	57012841	114102226	66	25586										
CASP8AP2	9994	broad.mit.edu	37	chr6	90573429	90573429	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gttaggtctgttgacaatacTatgcattgtgaagagcccat	10	7	1	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:90573429T>A	uc003pnr.2	+	7	2197	c.2001T>A	c.(1999-2001)ACT>ACA	p.T667T	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Silent_p.T667T|CASP8AP2_uc011dzz.1_Silent_p.T667T	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	667					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TTGACAATACTATGCATTGTG	0.418													0	0	0	0.010504	0	20	11										A	90573429	T	A	90573429	2	1	86	1	0	0	0	0	0	0	0	1	2678	1509	53	5		5	CASP8AP2	6	90573429	Silent	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	33560588	90573429	80541638	67	25587										
PLEKHG1	57480	broad.mit.edu	37	chr6	151130805	151130805	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccaaatcccagcaagacaaaCgcctctgggttctgcaccta	7	15	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:151130805C>T	uc003qny.1	+	11	1525	c.1213C>T	c.(1213-1215)CGC>TGC	p.R405C	PLEKHG1_uc011eel.1_Missense_Mutation_p.R445C|PLEKHG1_uc011eem.1_Missense_Mutation_p.R464C|PLEKHG1_uc003qnz.2_Missense_Mutation_p.R405C	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	405	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GCAAGACAAACGCCTCTGGGT	0.473													0	0	0	0.020292	0	15	27										T	151130805	C	T	151130805	3	4	86	1	0	0	0	0	1	0	0	0	12068	536	19	2	1247	2	PLEKHG1	6	151130805	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	60557376	151130805	19984262	68	25588										
SYNE1	23345	broad.mit.edu	37	chr6	152551705	152551705	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acagtctttcagtgcattttGaacagaagcctgatctccaa	7	10	3	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr6:152551705G>A	uc010kiw.2	-	115	21774	c.21172C>T	c.(21172-21174)CAA>TAA	p.Q7058*	SYNE1_uc010kiv.2_Nonsense_Mutation_p.Q1582*|SYNE1_uc003qos.3_Nonsense_Mutation_p.Q1582*|SYNE1_uc003qot.3_Nonsense_Mutation_p.Q6987*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q7058*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7058	Cytoplasmic (Potential).|Spectrin 22.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGTGCATTTTGAACAGAAGCC	0.388										HNSCC(10;0.0054)			0	0	0	0.007413	0	15	120										A	152551705	G	A	152551705	4	1	86	1	0	0	0	0	0	1	0	0	15442	1299	45	1	5422	1	SYNE1	6	152551705	Nonsense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1420900	152551705	18563362	69	25589										
PLEKHA8	84725	broad.mit.edu	37	chr7	30094400	30094400	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	taacttgactcagtctggatCagactcaagttgctctccgg	9	11	5	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:30094400C>G	uc003tam.1	+	8	963	c.872C>G	c.(871-873)TCA>TGA	p.S291*	PLEKHA8_uc003tao.2_Nonsense_Mutation_p.S175*|PLEKHA8_uc003tap.1_Nonsense_Mutation_p.S291*|PLEKHA8_uc003tan.2_Nonsense_Mutation_p.S291*	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	291					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						CAGTCTGGATCAGACTCAAGT	0.388													0	0	0	0.014323	0	22	68										G	30094400	C	G	30094400	4	3	86	1	0	0	0	0	0	1	0	0	12062	838	29	1	902	1	PLEKHA8	7	30094400	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		30094400	129044263	70	25590										
PKD1L1	168507	broad.mit.edu	37	chr7	47930253	47930253	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcatagctgtcactgagccaTtgtgcctcaaaggaaacagt	9	10	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:47930253T>C	uc003tny.1	-	16	2562	c.2562A>G	c.(2560-2562)CAA>CAG	p.Q854Q		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	854	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CACTGAGCCATTGTGCCTCAA	0.602													0	0	0	0.004482	0	9	41										C	47930253	T	C	47930253	2	2	86	1	0	0	0	0	0	0	0	1	11964	1490	52	5		5	PKD1L1	7	47930253	Silent	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	17835853	47930253	111208410	71	25591										
ZNF107	51427	broad.mit.edu	37	chr7	64168367	64168367	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	agaacatggcaaagtttttaAccagtcctcaaaccttacta	5	10	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:64168367A>T	uc003ttd.2	+	7	2471	c.1685A>T	c.(1684-1686)AAC>ATC	p.N562I	ZNF107_uc003tte.2_Missense_Mutation_p.N562I	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	562	C2H2-type 18; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AAAGTTTTTAACCAGTCCTCA	0.348													0	0	0	0.009535	0	32	50										T	64168367	A	T	64168367	3	4	86	1	0	0	0	0	1	0	0	0	17712	43	2	5	1691	5	ZNF107	7	64168367	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	16238114	64168367	94970296	72	25592										
ZNF804B	219578	broad.mit.edu	37	chr7	88965564	88965564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctggtgtgactgattcaacaGagacccaagaagaccaaata	9	9	1	5			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:88965564G>C	uc011khi.1	+	4	3806	c.3268G>C	c.(3268-3270)GAG>CAG	p.E1090Q		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1090						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TGATTCAACAGAGACCCAAGA	0.363										HNSCC(36;0.09)			0	0	0	0.00499	0	18	49										C	88965564	G	C	88965564	3	2	86	1	0	0	0	0	1	0	0	0	18168	943	33	1	3282	1	ZNF804B	7	88965564	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	24797197	88965564	70173099	73	25593										
CADPS2	93664	broad.mit.edu	37	chr7	122261661	122261661	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttaaattccggaccacctttCgaaactggaagactttccaa	6	11	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:122261661C>T	uc010lkp.2	-	5	1141	c.978G>A	c.(976-978)TCG>TCA	p.S326S	CADPS2_uc003vkg.3_Silent_p.S26S|CADPS2_uc010lkq.2_Silent_p.S326S	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	326					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						GACCACCTTTCGAAACTGGAA	0.368													0	0	0	0.028581	0	17	69										T	122261661	C	T	122261661	2	4	86	1	0	0	0	0	0	0	0	1	2571	871	31	1		1	CADPS2	7	122261661	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	33296097	122261661	36877002	74	25594										
ZC3HC1	51530	broad.mit.edu	37	chr7	129680811	129680811	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	atctgtcaaagtcaaaagctGgttgtaaactggcacagaga	10	7	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:129680811G>T	uc003vpi.2	-	3	416	c.389C>A	c.(388-390)CCA>CAA	p.P130Q	ZC3HC1_uc003vph.2_Missense_Mutation_p.P17Q|ZC3HC1_uc010lma.2_Missense_Mutation_p.P17Q	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	130	C3HC-type.				cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					GTCAAAAGCTGGTTGTAAACT	0.418													1	0	8.88839e-20	0.010818	1.01971e-19	32	129										T	129680811	G	T	129680811	3	4	86	1	0	0	0	0	1	0	0	0	17574	1348	47	4	1151	4	ZC3HC1	7	129680811	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	7419150	129680811	29457852	75	25595										
GIMAP8	155038	broad.mit.edu	37	chr7	150171609	150171609	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	agtgtaaaaacagatatagtGccttcaactaccgggcaaca	8	9	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:150171609G>A	uc003whj.2	+	4	1522	c.1192G>A	c.(1192-1194)GCC>ACC	p.A398T		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	398						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAGATATAGTGCCTTCAACTA	0.443													0	0	0	0.016522	0	24	110										A	150171609	G	A	150171609	3	1	86	1	0	0	0	0	1	0	0	0	6385	1319	46	2	1202	2	GIMAP8	7	150171609	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	20490798	150171609	8967054	76	25596										
DPP6	1804	broad.mit.edu	37	chr7	154595651	154595651	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aagatcctagcctacgatgaGaaggggaataagatgtgagt	13	5	0	4			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr7:154595651G>C	uc003wlk.2	+	14	1614	c.1485G>C	c.(1483-1485)GAG>GAC	p.E495D	DPP6_uc003wli.2_Missense_Mutation_p.E431D|DPP6_uc003wlm.2_Missense_Mutation_p.E433D|DPP6_uc011kvq.1_Missense_Mutation_p.E388D	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	495	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CCTACGATGAGAAGGGGAATA	0.502													0	0	0	0.009096	0	4	12										C	154595651	G	C	154595651	3	2	86	1	0	0	0	0	1	0	0	0	4730	933	33	1	1655	1	DPP6	7	154595651	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	4424042	154595651	4543012	77	25597										
ADRA1A	148	broad.mit.edu	37	chr8	26628136	26628136	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tagatatccgagccaaaataCtattttaaaaactgtttcag	5	7	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:26628136C>T	uc003xfh.1	-	2	1367	c.931G>A	c.(931-933)GTA>ATA	p.V311I	ADRA1A_uc003xfc.1_Missense_Mutation_p.V311I|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.V311I|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.V311I	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	311	Helical; Name=7; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity	p.V311I(1)		breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	AGCCAAAATACTATTTTAAAA	0.393													0	0	0	0.007413	0	19	62										T	26628136	C	T	26628136	3	4	86	1	0	0	0	0	1	0	0	0	334	565	20	2	764	2	ADRA1A	8	26628136	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		26628136	119735886	78	25598										
FZD3	7976	broad.mit.edu	37	chr8	28384671	28384671	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttttgttttttaggttcccaGattgtgatgagccatatcct	8	7	0	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:28384671G>A	uc003xgx.2	+	5	872	c.394G>A	c.(394-396)GAT>AAT	p.D132N	FZD3_uc010lvb.2_Missense_Mutation_p.D132N	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	132	FZ.|Extracellular (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TAGGTTCCCAGATTGTGATGA	0.423													0	0	0	0.009535	0	26	81										A	28384671	G	A	28384671	3	1	86	1	0	0	0	0	1	0	0	0	6131	942	33	1	404	1	FZD3	8	28384671	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1756535	28384671	117979351	79	25599										
TRPA1	8989	broad.mit.edu	37	chr8	72946563	72946563	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aactgtagacctcaacaaagTtttcaaaattacctccaaca	3	11	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:72946563T>A	uc003xza.2	-	22	2780	c.2605A>T	c.(2605-2607)ACT>TCT	p.T869S	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	869	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTCAACAAAGTTTTCAAAATT	0.294													0	0	0	0.016723	0	14	53										A	72946563	T	A	72946563	3	1	86	1	0	0	0	0	1	0	0	0	16574	1725	60	5	778	5	TRPA1	8	72946563	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	44561892	72946563	73417459	80	25600										
TRPA1	8989	broad.mit.edu	37	chr8	72964852	72964852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	accttttgctcctgatgatcGtaagaacaacctccttcctc	5	14	0	3	rs147715599		TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:72964852G>A	uc003xza.2	-	14	1968	c.1793C>T	c.(1792-1794)ACG>ATG	p.T598M	uc011lff.1_RNA|uc003xyy.2_RNA	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	598	ANK 15.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CCTGATGATCGTAAGAACAAC	0.448													0	0	0	0.016522	0	24	72										A	72964852	G	A	72964852	3	1	86	1	0	0	0	0	1	0	0	0	16574	1145	40	2	1622	2	TRPA1	8	72964852	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	18289	72964852	73399170	81	25601										
VPS13B	157680	broad.mit.edu	37	chr8	100866463	100866463	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccctggcaatgcactatgccGctggggccctttttagagca	11	13	0	1	rs149659649	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:100866463G>T	uc003yiv.2	+	56	11032	c.10921G>T	c.(10921-10923)GCT>TCT	p.A3641S	VPS13B_uc003yiw.2_Missense_Mutation_p.A3616S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3641					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GCACTATGCCGCTGGGGCCCT	0.552													1	0	2.37509e-13	0.010504	2.67556e-13	22	17										T	100866463	G	T	100866463	3	4	86	1	0	0	0	0	1	0	0	0	17187	1087	38	4	11333	4	VPS13B	8	100866463	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	27901611	100866463	45497559	82	25602										
OPLAH	26873	broad.mit.edu	37	chr8	145113243	145113243	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggcccgagagcacagcactgGagccgctgaaggtgtccatg	15	12	0	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr8:145113243G>A	uc003zar.3	-	7	930	c.848C>T	c.(847-849)TCC>TTC	p.S283F	OPLAH_uc003zat.1_Missense_Mutation_p.S61F	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	283							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CACAGCACTGGAGCCGCTGAA	0.687													0	0	0	0.009096	0	4	10										A	145113243	G	A	145113243	3	1	86	1	0	0	0	0	1	0	0	0	10876	1174	41	1	3104	1	OPLAH	8	145113243	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	44246780	145113243	1250779	83	25603										
TAF1L	138474	broad.mit.edu	37	chr9	32633772	32633772	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tggataatattccctccaaaGgtgccccgaagaccctgttg	9	12	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:32633772G>A	uc003zrg.1	-	1	1896	c.1806C>T	c.(1804-1806)ACC>ACT	p.T602T	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	602					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCCTCCAAAGGTGCCCCGAA	0.483													0	0	0	0.01441	0	55	126										A	32633772	G	A	32633772	2	1	86	1	0	0	0	0	0	0	0	1	15520	987	35	2		2	TAF1L	9	32633772	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		32633772	108579659	84	25604										
ABCA1	19	broad.mit.edu	37	chr9	107580989	107580989	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctactgtttctgcaggaactGagggaggattccacatcttt	10	9	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:107580989G>A	uc004bcl.2	-	23	3730	c.3417C>T	c.(3415-3417)CTC>CTT	p.L1139L		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1139					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGCAGGAACTGAGGGAGGATT	0.537													0	0	0	0.021553	0	6	84										A	107580989	G	A	107580989	2	1	86	1	0	0	0	0	0	0	0	1	28	1277	45	1		1	ABCA1	9	107580989	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	74947217	107580989	33632442	85	25605										
SVEP1	79987	broad.mit.edu	37	chr9	113149637	113149637	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctcagatggcccttcaagacTgtagcctctgttgcaggaat	10	11	3	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:113149637T>C	uc010mtz.2	-	42	10325	c.9988A>G	c.(9988-9990)AGT>GGT	p.S3330G	SVEP1_uc010mty.2_Missense_Mutation_p.S1256G	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3330	Sushi 32.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCTTCAAGACTGTAGCCTCTG	0.483													0	0	0	0.006122	0	19	50										C	113149637	T	C	113149637	3	2	86	1	0	0	0	0	1	0	0	0	15417	1580	55	5	755	5	SVEP1	9	113149637	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	5568648	113149637	28063794	86	25606										
SPTAN1	6709	broad.mit.edu	37	chr9	131388859	131388859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctgacttcaaccagctggccGagctggaccgccagatcaag	11	14	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:131388859G>A	uc004bvl.3	+	48	6567	c.6454G>A	c.(6454-6456)GAG>AAG	p.E2152K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E2157K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E2132K|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2152	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCAGCTGGCCGAGCTGGACCG	0.597													0	0	0	0.013537	0	13	36										A	131388859	G	A	131388859	3	1	86	1	0	0	0	0	1	0	0	0	15116	1059	37	1	6659	1	SPTAN1	9	131388859	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	18239222	131388859	9824572	87	25607										
COL5A1	1289	broad.mit.edu	37	chr9	137710579	137710579	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gcccctgggaagcccggaccGgatggccttcgagggatccc	15	15	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:137710579G>A	uc004cfe.2	+	55	4690	c.4308G>A	c.(4306-4308)CCG>CCA	p.P1436P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1436	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCCCGGACCGGATGGCCTTC	0.697													0	0	0	0.014758	0	4	12										A	137710579	G	A	137710579	2	1	86	1	0	0	0	0	0	0	0	1	3696	1103	39	2		2	COL5A1	9	137710579	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	6321720	137710579	3502852	88	25608										
NOTCH1	4851	broad.mit.edu	37	chr9	139393627	139393627	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtcctccagcatgccctccaCggccaggcgggcagccagga	13	17	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:139393627C>T	uc004chz.2	-	32	6019	c.6019G>A	c.(6019-6021)GTG>ATG	p.V2007M		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2007	ANK 3.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGCCCTCCACGGCCAGGCGG	0.657			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.006122	0	18	27										T	139393627	C	T	139393627	3	4	86	1	0	0	0	0	1	0	0	0	10547	536	19	2	1660	2	NOTCH1	9	139393627	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1683048	139393627	1819804	89	25609										
C9orf172	389813	broad.mit.edu	37	chr9	139739888	139739888	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cccaatccaggaaccgccctCccgctcctactatggggagg	10	17	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr9:139739888C>T	uc011meh.1	+	1	1022	c.1022C>T	c.(1021-1023)TCC>TTC	p.S341F	PHPT1_uc004cjp.2_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	341	Pro-rich.										0						GAACCGCCCTCCCGCTCCTAC	0.701													0	0	0	0.014758	0	5	17										T	139739888	C	T	139739888	3	4	86	1	0	0	0	0	1	0	0	0	2471	855	30	1	1024	1	C9orf172	9	139739888	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	346261	139739888	1473543	90	25610										
KIAA1274	27143	broad.mit.edu	37	chr10	72300920	72300920	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aaggacccaggcactggcttCgtgttcagctgcctcagcgg	13	13	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr10:72300920C>T	uc001jrd.3	+	16	2252	c.1971C>T	c.(1969-1971)TTC>TTT	p.F657F	KIAA1274_uc001jre.3_5'UTR	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	657										ovary(2)|central_nervous_system(1)	3						GCACTGGCTTCGTGTTCAGCT	0.632													0	0	0	0.013537	0	13	49										T	72300920	C	T	72300920	2	4	86	1	0	0	0	0	0	0	0	1	8220	883	31	1		1	KIAA1274	10	72300920	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		72300920	63233827	91	25611										
OR52B2	255725	broad.mit.edu	37	chr11	6191265	6191265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gaagccttgggtgacacaggCatcaaaagcaatgttatgtg	12	7	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:6191265C>T	uc010qzy.1	-	1	292	c.292G>A	c.(292-294)GCC>ACC	p.A98T		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGACACAGGCATCAAAAGCA	0.517													0	0	0	0.006122	0	18	71										T	6191265	C	T	6191265	3	4	86	1	0	0	0	0	1	0	0	0	11111	710	25	2	682	2	OR52B2	11	6191265	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		6191265	128815251	92	25612										
FAM160A2	84067	broad.mit.edu	37	chr11	6243787	6243787	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aagcaggctctgagatactcCgtaggaaaagttccagatag	11	8	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:6243787C>T	uc001mcl.3	-	6	1435	c.1076G>A	c.(1075-1077)CGG>CAG	p.R359Q	FAM160A2_uc001mck.3_Missense_Mutation_p.R359Q|FAM160A2_uc001mcm.2_Missense_Mutation_p.R359Q	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	359					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						TGAGATACTCCGTAGGAAAAG	0.527													0	0	0	0.010504	0	17	37										T	6243787	C	T	6243787	3	4	86	1	0	0	0	0	1	0	0	0	5469	652	23	2	1912	2	FAM160A2	11	6243787	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	52522	6243787	128762729	93	25613										
KCNA4	3739	broad.mit.edu	37	chr11	30033452	30033452	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gcctcctcccccaactgataGaacttcacctcctcagtgaa	5	17	2	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:30033452G>C	uc001msk.2	-	2	1926	c.774C>G	c.(772-774)TTC>TTG	p.F258L		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	258						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCAACTGATAGAACTTCACCT	0.507													0	0	0	0.012319	0	19	59										C	30033452	G	C	30033452	3	2	86	1	0	0	0	0	1	0	0	0	8005	933	33	1	1191	1	KCNA4	11	30033452	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	23789665	30033452	104973064	94	25614										
ESRRA	2101	broad.mit.edu	37	chr11	64082320	64082320	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggcacctcccagccgtggctAccctctgtgacctctttgac	9	17	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64082320A>G	uc001nzq.1	+	5	856	c.679A>G	c.(679-681)ACC>GCC	p.T227A	ESRRA_uc001nzr.1_Missense_Mutation_p.T226A|ESRRA_uc001nzs.1_Missense_Mutation_p.T227A|ESRRA_uc009ypn.1_Intron	NM_004451	NP_004442	P11474	ERR1_HUMAN	estrogen-related receptor alpha	227	Ligand binding domain.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein domain specific binding|sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0						AGCCGTGGCTACCCTCTGTGA	0.612													0	0	0	0.013537	0	12	21										G	64082320	A	G	64082320	3	3	86	1	0	0	0	0	1	0	0	0	5260	391	14	5	693	5	ESRRA	11	64082320	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	34048868	64082320	70924196	95	25615										
TM7SF2	7108	broad.mit.edu	37	chr11	64882277	64882277	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtcaatggcttccagttgctCtacgtgggtgatgccctctg	12	11	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64882277C>G	uc001oct.2	+	6	843	c.696C>G	c.(694-696)CTC>CTG	p.L232L	TM7SF2_uc010rny.1_Silent_p.L116L|TM7SF2_uc001ocu.2_Silent_p.L232L|TM7SF2_uc001ocv.2_Silent_p.L253L|uc009yqb.1_5'Flank	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	232					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1						TCCAGTTGCTCTACGTGGGTG	0.607													0	0	0	0.010729	0	10	66										G	64882277	C	G	64882277	2	3	86	1	0	0	0	0	0	0	0	1	15971	900	32	1		1	TM7SF2	11	64882277	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	799957	64882277	70124239	96	25616			1	115		3	3	1961	C		4.360772e-05
ZNHIT2	741	broad.mit.edu	37	chr11	64884048	64884048	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttggtgagccctggcgcagtCtagggccaggggtgtgaggg	20	8	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64884048C>T	uc001ocw.2	-	1	1123	c.1078G>A	c.(1078-1080)GAC>AAC	p.D360N	uc009yqb.1_5'UTR	NM_014205	NP_055020	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT domain containing 2	360							metal ion binding			breast(1)	1						CTGGCGCAGTCTAGGGCCAGG	0.647													0	0	0	0.020292	0	15	64										T	64884048	C	T	64884048	3	4	86	1	0	0	0	0	1	0	0	0	18204	913	32	1	137	1	ZNHIT2	11	64884048	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	1771	64884048	70122468	97	25617			1	115		3	3	1961	C		4.360772e-05
ZNHIT2	741	broad.mit.edu	37	chr11	64884237	64884237	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tttctggttggtcgggccctCgcccagcaggatgcgggcga	16	12	1	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:64884237C>A	uc001ocw.2	-	1	934	c.889G>T	c.(889-891)GAG>TAG	p.E297*	uc009yqb.1_Silent_p.L36L	NM_014205	NP_055020	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT domain containing 2	297							metal ion binding			breast(1)	1						GTCGGGCCCTCGCCCAGCAGG	0.711													1	0	1.5842e-08	0.016723	1.70256e-08	13	44										A	64884237	C	A	64884237	4	1	86	1	0	0	0	0	0	1	0	0	18204	893	31	3	326	3	ZNHIT2	11	64884237	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	189	64884237	70122279	98	25618			1	115		3	3	1961	C		4.360772e-05
CCDC83	220047	broad.mit.edu	37	chr11	85593685	85593685	+	Frame_Shift_Del	DEL	A	A	-													0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aagcgatgaaggaaaaatggAagtttgaaagagaccaggaa							TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:85593685delA	uc001pbh.1	+	4	822	c.310delA	c.(310-312)AAGfs	p.K104fs	CCDC83_uc001pbg.1_Frame_Shift_Del_p.K104fs|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Frame_Shift_Del_p.K61fs	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	104	Potential.									skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				GGAAAAATGGAAGTTTGAAAG	0.378																		23	75	---	---								-	85593685	A	-	85593685	7	5	86	1	0	1	0	1	0	0	0	0	2857	247	9	0	320	0	CCDC83	11	85593685	Frame_Shift_Del	DEL	A	TCGA-FD-A3SR-01A-11D-A22Z-08	20709448	85593685	49412831	99	25619										
CEP164	22897	broad.mit.edu	37	chr11	117266864	117266864	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cacattttgagccagatctcCatattgaggacctgaggaaa	9	9	1	4			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:117266864C>T	uc001prc.2	+	25	3331	c.3184C>T	c.(3184-3186)CAT>TAT	p.H1062Y	CEP164_uc001prb.2_Missense_Mutation_p.H1065Y|CEP164_uc010rxk.1_Missense_Mutation_p.H1036Y|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.H495Y	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1062					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GCCAGATCTCCATATTGAGGA	0.572													0	0	0	0.008361	0	29	110										T	117266864	C	T	117266864	3	4	86	1	0	0	0	0	1	0	0	0	3249	594	21	2	3274	2	CEP164	11	117266864	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	31673179	117266864	17739652	100	25620										
IL10RA	3587	broad.mit.edu	37	chr11	117864081	117864081	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aaagcatcttcagtcacttcCgagagtatgagattgccatt	8	9	3	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:117864081C>T	uc001prv.2	+	4	570	c.493C>T	c.(493-495)CGA>TGA	p.R165*	IL10RA_uc010rxl.1_Nonsense_Mutation_p.R145*|IL10RA_uc010rxm.1_Nonsense_Mutation_p.R145*|IL10RA_uc010rxn.1_Nonsense_Mutation_p.R16*|IL10RA_uc001prw.2_Nonsense_Mutation_p.R16*	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	165	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		CAGTCACTTCCGAGAGTATGA	0.557													0	0	0	0.013537	0	13	56										T	117864081	C	T	117864081	4	4	86	1	0	0	0	0	0	1	0	0	7620	644	23	2	507	2	IL10RA	11	117864081	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	597217	117864081	17142435	101	25621										
OR10S1	219873	broad.mit.edu	37	chr11	123848028	123848028	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctgtgtacaggaagcactcaGtgctggccagaaagtggaag	14	8	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr11:123848028G>A	uc001pzm.1	-	1	371	c.371C>T	c.(370-372)ACT>ATT	p.T124I		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	124	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GAAGCACTCAGTGCTGGCCAG	0.542													0	0	0	0.004482	0	8	23										A	123848028	G	A	123848028	3	1	86	1	0	0	0	0	1	0	0	0	10918	1029	36	2	628	2	OR10S1	11	123848028	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	5983947	123848028	11158488	102	25622										
EPS8	2059	broad.mit.edu	37	chr12	15807190	15807190	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcaataggggactaagtactGaactggctagttcaggacct	11	8	2	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:15807190G>T	uc009zif.2	-	13	1233	c.1139C>A	c.(1138-1140)TCA>TAA	p.S380*	EPS8_uc001rdb.2_Nonsense_Mutation_p.S380*|EPS8_uc009zig.2_Nonsense_Mutation_p.S120*|EPS8_uc010shv.1_Nonsense_Mutation_p.S120*	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	380					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		ACTAAGTACTGAACTGGCTAG	0.383													1	0	2.61681e-11	0.020292	2.86166e-11	15	68										T	15807190	G	T	15807190	4	4	86	1	0	0	0	0	0	1	0	0	5194	1294	45	3	1365	3	EPS8	12	15807190	Nonsense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		15807190	118044705	103	25623										
ARID2	196528	broad.mit.edu	37	chr12	46243818	46243818	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acgttttcttcatattttcaGgaatccctcatggatcacaa	5	10	5	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:46243818G>A	uc001ros.1	+	15	1913	c.1913_splice	c.e15-1	p.G638_splice	ARID2_uc001ror.2_Splice_Site_p.G638_splice|ARID2_uc009zkg.1_Splice_Site_p.G94_splice|ARID2_uc009zkh.1_Splice_Site_p.G265_splice|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CATATTTTCAGGAATCCCTCA	0.333													0	0	0	0.010818	0	33	53										A	46243818	G	A	46243818	5	1	86	1	0	0	0	0	0	0	1	0	915	1014	35	2	1970	2	ARID2	12	46243818	Splice_Site	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	30436628	46243818	87608077	104	25624										
SLC38A2	54407	broad.mit.edu	37	chr12	46765027	46765027	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgttggaactgtagctgctgCtgtcttcatccggggaaata	12	8	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:46765027C>T	uc001rpg.2	-	2	490	c.50G>A	c.(49-51)AGC>AAC	p.S17N	SLC38A2_uc001rph.2_5'UTR	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	17	Cytoplasmic (Potential).|Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		GTAGCTGCTGCTGTCTTCATC	0.512													0	0	0	0.015359	0	33	121										T	46765027	C	T	46765027	3	4	86	1	0	0	0	0	1	0	0	0	14604	797	28	2	1530	2	SLC38A2	12	46765027	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	521209	46765027	87086868	105	25625										
KRT73	319101	broad.mit.edu	37	chr12	53012246	53012246	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctgccccctgagagcacagcGgagcagccgctgaagccccc	12	18	0	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:53012246G>A	uc001sas.2	-	1	98	c.63C>T	c.(61-63)TCC>TCT	p.S21S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	21	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGAGCACAGCGGAGCAGCCGC	0.642													0	0	0	0.009535	0	26	52										A	53012246	G	A	53012246	2	1	86	1	0	0	0	0	0	0	0	1	8486	1103	39	2		2	KRT73	12	53012246	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	6247219	53012246	80839649	106	25626										
HOXC8	3224	broad.mit.edu	37	chr12	54405067	54405067	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggaaaaaggagaacaacaagGataaactgccgggagcccga	13	8	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:54405067G>A	uc001ser.2	+	2	810	c.631G>A	c.(631-633)GAT>AAT	p.D211N		NM_022658	NP_073149	P31273	HXC8_HUMAN	homeobox C8	211						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAACAACAAGGATAAACTGCC	0.343													0	0	0	0.00499	0	17	49										A	54405067	G	A	54405067	3	1	86	1	0	0	0	0	1	0	0	0	7316	1174	41	1	637	1	HOXC8	12	54405067	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1392821	54405067	79446828	107	25627										
NEUROD4	58158	broad.mit.edu	37	chr12	55420612	55420612	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttccaagatagagactcttaGactggccaggaactatattt	8	8	1	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:55420612G>C	uc001sgp.3	+	2	767	c.389G>C	c.(388-390)AGA>ACA	p.R130T		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	130	Helix-loop-helix motif.				amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						GAGACTCTTAGACTGGCCAGG	0.502													0	0	0	0.00499	0	16	67										C	55420612	G	C	55420612	3	2	86	1	0	0	0	0	1	0	0	0	10350	942	33	1	391	1	NEUROD4	12	55420612	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1015545	55420612	78431283	108	25628										
DGKA	1606	broad.mit.edu	37	chr12	56334764	56334764	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	agcacctctgaggctctgcgGgtacagggctgagagtcttg	15	10	3	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:56334764G>A	uc001sij.2	+	13	1365	c.1101G>A	c.(1099-1101)CGG>CGA	p.R367R	DGKA_uc001sih.1_Silent_p.R255R|DGKA_uc001sii.1_Silent_p.R225R|DGKA_uc009zod.1_Silent_p.R286R|DGKA_uc001sik.2_Silent_p.R367R|DGKA_uc001sil.2_Silent_p.R367R|DGKA_uc001sim.2_Silent_p.R367R|DGKA_uc001sin.2_Silent_p.R367R|DGKA_uc009zof.2_Silent_p.R13R|DGKA_uc001sio.2_Silent_p.R109R	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	367					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	AGGCTCTGCGGGTACAGGGCT	0.542													0	0	0	0.001984	0	7	27										A	56334764	G	A	56334764	2	1	86	1	0	0	0	0	0	0	0	1	4465	1246	43	2		2	DGKA	12	56334764	Silent	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	914152	56334764	77517131	109	25629										
ERP29	10961	broad.mit.edu	37	chr12	112451286	112451286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cgatatggctgccgctgtgcCccgcgccgcatttctctccc	10	18	1	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:112451286C>T	uc001ttk.1	+	1	135	c.17C>T	c.(16-18)CCC>CTC	p.P6L	ERP29_uc001ttl.1_Missense_Mutation_p.P6L|TMEM116_uc001ttc.1_5'Flank|TMEM116_uc001ttd.1_5'Flank|TMEM116_uc001tte.1_5'Flank|TMEM116_uc001ttf.1_5'Flank|TMEM116_uc001ttg.1_5'Flank|TMEM116_uc001tth.1_5'Flank|TMEM116_uc001tti.1_5'Flank|TMEM116_uc001ttj.1_5'Flank	NM_006817	NP_006808	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29 isoform 1	6					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity				0						GCCGCTGTGCCCCGCGCCGCA	0.682													0	0	0	0.020292	0	14	58										T	112451286	C	T	112451286	3	4	86	1	0	0	0	0	1	0	0	0	5242	623	22	2	19	2	ERP29	12	112451286	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	56116522	112451286	21400609	110	25630										
NCOR2	9612	broad.mit.edu	37	chr12	124820110	124820110	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggggagccccttgtcgtgggTcagactgggtgagctcacag	17	10	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:124820110T>C	uc010tay.1	-	41	6370	c.6214A>G	c.(6214-6216)ACC>GCC	p.T2072A	NCOR2_uc010taz.1_Missense_Mutation_p.T2056A|NCOR2_uc010tax.1_Missense_Mutation_p.T183A	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2073					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTGTCGTGGGTCAGACTGGGT	0.677													0	0	0	0.014758	0	4	21										C	124820110	T	C	124820110	3	2	86	1	0	0	0	0	1	0	0	0	10236	1667	58	5	1396	5	NCOR2	12	124820110	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	12368824	124820110	9031785	111	25631										
PIWIL1	9271	broad.mit.edu	37	chr12	130840202	130840202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aacagaaaagattcaccaagGtggaaaaacagtaaggcagt	10	6	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:130840202G>A	uc001uik.2	+	12	1484	c.1394G>A	c.(1393-1395)GGT>GAT	p.G465D	PIWIL1_uc001uij.1_Missense_Mutation_p.G465D	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	465					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATTCACCAAGGTGGAAAAACA	0.249													0	0	0	0.006214	0	10	106										A	130840202	G	A	130840202	3	1	86	1	0	0	0	0	1	0	0	0	11957	1261	44	2	1436	2	PIWIL1	12	130840202	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	6020092	130840202	3011693	112	25632										
GPR133	283383	broad.mit.edu	37	chr12	131593323	131593323	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acttcttcctgagtgccttcGcatggatgctggtggagggg	15	9	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr12:131593323G>A	uc001uit.3	+	18	2501	c.1942G>A	c.(1942-1944)GCA>ACA	p.A648T	GPR133_uc010tbm.1_Missense_Mutation_p.A680T|GPR133_uc009zyo.2_Intron|GPR133_uc001uiv.1_Missense_Mutation_p.A167T|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	648	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGTGCCTTCGCATGGATGCT	0.517													0	0	0	0.013726	0	31	145										A	131593323	G	A	131593323	3	1	86	1	0	0	0	0	1	0	0	0	6643	1087	38	2	2012	2	GPR133	12	131593323	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	753121	131593323	2258572	113	25633										
SPG20	23111	broad.mit.edu	37	chr13	36909198	36909198	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggtttagaaccgtatcgagaGaattatccaaaaacctcaca	7	9	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr13:36909198G>C	uc001uvn.2	-	3	1040	c.770C>G	c.(769-771)TCT>TGT	p.S257C	SPG20_uc010ten.1_Missense_Mutation_p.S257C|SPG20_uc001uvm.2_Missense_Mutation_p.S257C|SPG20_uc001uvo.2_Missense_Mutation_p.S257C|SPG20_uc001uvq.2_Missense_Mutation_p.S257C|SPG20_uc001uvp.2_Missense_Mutation_p.S257C	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	257					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CGTATCGAGAGAATTATCCAA	0.388													0	0	0	0.017118	0	31	98										C	36909198	G	C	36909198	3	2	86	1	0	0	0	0	1	0	0	0	15041	942	33	1	1262	1	SPG20	13	36909198	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		36909198	78260680	114	25634										
PRMT5	10419	broad.mit.edu	37	chr14	23393862	23393862	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgctggtactgagagtatttGatggggtccttttcaaacac	11	7	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:23393862G>C	uc001whm.1	-	9	1087	c.996C>G	c.(994-996)ATC>ATG	p.I332M	PRMT5_uc001whl.1_Missense_Mutation_p.I315M|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Missense_Mutation_p.I226M|PRMT5_uc010tng.1_Missense_Mutation_p.I271M|PRMT5_uc010tnh.1_Missense_Mutation_p.I288M|PRMT5_uc001whn.1_Missense_Mutation_p.I161M	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	332					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GAGAGTATTTGATGGGGTCCT	0.478													0	0	0	0.021553	0	6	52										C	23393862	G	C	23393862	3	2	86	1	0	0	0	0	1	0	0	0	12539	1280	45	1	953	1	PRMT5	14	23393862	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		23393862	83955678	115	25635										
YLPM1	56252	broad.mit.edu	37	chr14	75265975	75265975	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	caagaatcacagtttcgtgaAcgggatattccatctcttcc	7	11	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:75265975A>G	uc001xqj.3	+	5	4099	c.3975A>G	c.(3973-3975)GAA>GAG	p.E1325E	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1130	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGTTTCGTGAACGGGATATTC	0.443													0	0	0	0.006122	0	19	64										G	75265975	A	G	75265975	2	3	86	1	0	0	0	0	0	0	0	1	17483	40	2	5		5	YLPM1	14	75265975	Silent	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	51872113	75265975	32083565	116	25636										
SERPINA12	145264	broad.mit.edu	37	chr14	94964104	94964104	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	catgccaaaagccttacctcGaaagaaaatataatttgcaa	5	9	0	1	rs61757459	byFrequency	TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:94964104G>C	uc001ydj.2	-	3	1427	c.631C>G	c.(631-633)CGA>GGA	p.R211G		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	211					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GCCTTACCTCGAAAGAAAATA	0.219													0	0	0	0.010504	0	19	64										C	94964104	G	C	94964104	3	2	86	1	0	0	0	0	1	0	0	0	14089	1066	37	1	629	1	SERPINA12	14	94964104	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	19698129	94964104	12385436	117	25637										
HSP90AA1	3320	broad.mit.edu	37	chr14	102550835	102550835	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctttctgttttcaaacagatCaaaaggagcacgtcgtggga	10	8	3	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr14:102550835C>G	uc001yku.3	-	6	1238	c.1048G>C	c.(1048-1050)GAT>CAT	p.D350H	HSP90AA1_uc001ykv.3_Missense_Mutation_p.D472H|HSP90AA1_uc001ykw.1_Missense_Mutation_p.D171H|HSP90AA1_uc001ykx.1_Missense_Mutation_p.D339H	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	350					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	TCAAACAGATCAAAAGGAGCA	0.373													0	0	0	0.020292	0	15	61										G	102550835	C	G	102550835	3	3	86	1	0	0	0	0	1	0	0	0	7401	826	29	1	1174	1	HSP90AA1	14	102550835	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	7586731	102550835	4798705	118	25638										
OTUD7A	161725	broad.mit.edu	37	chr15	31793915	31793915	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgttctctttgctggtctctCtgttccatggacacaagggc	10	11	3	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr15:31793915C>G	uc001zfq.2	-	8	1221	c.1128G>C	c.(1126-1128)CAG>CAC	p.Q376H	OTUD7A_uc001zfr.2_Missense_Mutation_p.Q383H	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	376	Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GCTGGTCTCTCTGTTCCATGG	0.577													0	0	0	0.006214	0	9	57										G	31793915	C	G	31793915	3	3	86	1	0	0	0	0	1	0	0	0	11318	912	32	1	1668	1	OTUD7A	15	31793915	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		31793915	70737477	119	25639										
CASC5	57082	broad.mit.edu	37	chr15	40917795	40917795	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcataaggagaaaaaaatcaGaaaaaatgagattaagttta	7	2	2	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr15:40917795G>T	uc010bbs.1	+	11	5572	c.5411G>T	c.(5410-5412)AGA>ATA	p.R1804I	CASC5_uc010ucq.1_Missense_Mutation_p.R1628I|CASC5_uc001zme.2_Missense_Mutation_p.R1778I|CASC5_uc010bbt.1_Missense_Mutation_p.R1778I	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1804					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAAAAAATCAGAAAAAATGAG	0.333													1	0	5.9392e-07	0.021553	6.3104e-07	5	37										T	40917795	G	T	40917795	3	4	86	1	0	0	0	0	1	0	0	0	2663	942	33	3	5449	3	CASC5	15	40917795	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	9123880	40917795	61613597	120	25640										
CCDC101	112869	broad.mit.edu	37	chr16	28602255	28602255	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gatccatgcgcccccacagcGggtaaagcagcctccagggg	13	15	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:28602255G>A	uc002dqf.2	+	9	949	c.764G>A	c.(763-765)CGG>CAG	p.R255Q	uc010vct.1_Intron	NM_138414	NP_612423	Q96ES7	SGF29_HUMAN	coiled-coil domain containing 101	255	SGF29 C-terminal.				establishment of protein localization to chromatin|histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|SAGA-type complex	methylated histone residue binding			central_nervous_system(1)	1						CCCCCACAGCGGGTAAAGCAG	0.617													0	0	0	0.004672	0	3	13										A	28602255	G	A	28602255	3	1	86	1	0	0	0	0	1	0	0	0	2735	1130	39	2	794	2	CCDC101	16	28602255	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		28602255	61752498	121	25641										
PARD6A	50855	broad.mit.edu	37	chr16	67695381	67695381	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gacgccgagttccgacgcttCgcgctgcctcgcgcttcggt	13	16	0	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:67695381C>A	uc002ett.2	+	2	178	c.87C>A	c.(85-87)TTC>TTA	p.F29L	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Missense_Mutation_p.F29L|PARD6A_uc002etu.2_5'UTR	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	29	Interaction with PRKCI and PRKCZ.|OPR.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TCCGACGCTTCGCGCTGCCTC	0.662													1	0	3.51602e-12	0.008871	3.8905e-12	18	67										A	67695381	C	A	67695381	3	1	86	1	0	0	0	0	1	0	0	0	11445	883	31	3	93	3	PARD6A	16	67695381	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	39093126	67695381	22659372	122	25642										
HYDIN	54768	broad.mit.edu	37	chr16	71220684	71220684	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cattcggtttacttcttcttCtgtaaccacctttggactca	5	12	4	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr16:71220684C>A	uc002ezr.2	-	2	243	c.115G>T	c.(115-117)GAA>TAA	p.E39*	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Nonsense_Mutation_p.E39*|HYDIN_uc010vmc.1_Nonsense_Mutation_p.E56*|HYDIN_uc010vmd.1_Nonsense_Mutation_p.E66*|HYDIN_uc002ezw.3_Nonsense_Mutation_p.E56*	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	39										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ACTTCTTCTTCTGTAACCACC	0.413													1	0	1.08611e-07	0.010729	1.16058e-07	12	65										A	71220684	C	A	71220684	4	1	86	1	0	0	0	0	0	1	0	0	7467	922	32	3	15599	3	HYDIN	16	71220684	Nonsense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	3525303	71220684	19134069	123	25643										
SPATA22	84690	broad.mit.edu	37	chr17	3352265	3352265	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tctgagtagctcggtttcttTgttgcgagataagttaggag	13	5	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:3352265T>C	uc002fvm.2	-	6	745	c.508A>G	c.(508-510)AAA>GAA	p.K170E	SPATA22_uc010vrg.1_Missense_Mutation_p.K154E|SPATA22_uc010vrf.1_Missense_Mutation_p.K170E|SPATA22_uc002fvn.2_Missense_Mutation_p.K170E|SPATA22_uc002fvo.2_Missense_Mutation_p.K170E|SPATA22_uc002fvp.2_Missense_Mutation_p.K170E|SPATA22_uc010ckf.2_Missense_Mutation_p.K127E	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	170											0						TCGGTTTCTTTGTTGCGAGAT	0.403													0	0	0	0.01441	0	71	175										C	3352265	T	C	3352265	3	2	86	1	0	0	0	0	1	0	0	0	15007	1821	63	5	599	5	SPATA22	17	3352265	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08		3352265	77842945	124	25644										
TP53	7157	broad.mit.edu	37	chr17	7577104	7577105	+	Frame_Shift_Ins	INS	-	-	GGACAGGC													0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ctgtgcgccggtctctcccaINSggacaggcacaaacacgcac							TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08			-	GGACAGGC	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:7577104_7577105insGGACAGGC	uc002gim.2	-	8	1027_1028	c.833_834insGCCTGTCC	c.(832-834)CCTfs	p.P278fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Ins_p.P278fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Ins_p.P146fs|TP53_uc010cng.1_Frame_Shift_Ins_p.P146fs|TP53_uc002gii.1_Frame_Shift_Ins_p.P146fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.P278fs|TP53_uc010cni.1_Frame_Shift_Ins_p.P278fs|TP53_uc002gij.2_Frame_Shift_Ins_p.P278fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	278	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P278L(52)|p.P278S(48)|p.P278R(26)|p.P278T(21)|p.P278A(17)|p.P278H(11)|p.0?(7)|p.P278fs*67(5)|p.P278F(3)|p.R280fs*65(2)|p.P278fs*28(2)|p.?(2)|p.G279fs*27(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.P278P(1)|p.C277_P278insXXXXXXX(1)|p.F270_D281del12(1)|p.P278_G279insXXXXX(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTCTCTCCCAGGACAGGCACA	0.554		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)								10	22	---	---								GGACAGGC	7577105	-	GGACAGGC	7577104	7	5	86	1	0	1	1	0	0	0	0	0	16378	175	7	0	452	0	TP53	17	7577104	Frame_Shift_Ins	INS	-	TCGA-FD-A3SR-01A-11D-A22Z-08	4224839	7577104	73618106	125	25645										
TP53	7157	broad.mit.edu	37	chr17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	actgcttgtagatggccatgGcgcggacgcgggtgccgggc	18	11	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:7578454G>A	uc002gim.2	-	5	670	c.476C>T	c.(475-477)GCC>GTC	p.A159V	TP53_uc002gig.1_Missense_Mutation_p.A159V|TP53_uc002gih.2_Missense_Mutation_p.A159V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27V|TP53_uc010cng.1_Missense_Mutation_p.A27V|TP53_uc002gii.1_Missense_Mutation_p.A27V|TP53_uc010cnh.1_Missense_Mutation_p.A159V|TP53_uc010cni.1_Missense_Mutation_p.A159V|TP53_uc002gij.2_Missense_Mutation_p.A159V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66V|TP53_uc002gio.2_Missense_Mutation_p.A27V|TP53_uc010vug.1_Missense_Mutation_p.A120V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006122	0	16	64										A	7578454	G	A	7578454	3	1	86	1	0	0	0	0	1	0	0	0	16378	1203	42	2	822	2	TP53	17	7578454	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	1350	7578454	73616756	126	25646										
CHD3	1107	broad.mit.edu	37	chr17	7808955	7808955	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcagggcgtagacagtcaaaGaggcagctccggaatgagaa	14	8	2	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr17:7808955G>C	uc002gje.2	+	27	4305	c.4155G>C	c.(4153-4155)AAG>AAC	p.K1385N	CHD3_uc002gjd.2_Missense_Mutation_p.K1444N|CHD3_uc002gjf.2_Missense_Mutation_p.K1385N|CHD3_uc002gjh.2_5'UTR|SCARNA21_uc002gji.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1385					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GACAGTCAAAGAGGCAGCTCC	0.567													0	0	0	0.021553	0	6	16										C	7808955	G	C	7808955	3	2	86	1	0	0	0	0	1	0	0	0	3326	933	33	1	4542	1	CHD3	17	7808955	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	230501	7808955	73386255	127	25647										
EMILIN2	84034	broad.mit.edu	37	chr18	2892374	2892374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gatgaacggaacgctcaggtCgcattccagagacatttctg	11	10	2	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:2892374C>T	uc002kln.2	+	4	2408	c.2249C>T	c.(2248-2250)TCG>TTG	p.S750L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	750					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		ACGCTCAGGTCGCATTCCAGA	0.483													0	0	0	0.008871	0	21	165										T	2892374	C	T	2892374	3	4	86	1	0	0	0	0	1	0	0	0	5094	893	31	1	2263	1	EMILIN2	18	2892374	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		2892374	75184874	128	25648										
C18orf1	753	broad.mit.edu	37	chr18	13645279	13645279	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccgacggtgaagagccacctCcttaccaggggccctgcacc	11	17	0	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:13645279C>T	uc002ksa.2	+	7	1212	c.544C>T	c.(544-546)CCT>TCT	p.P182S	C18orf1_uc002ksb.2_Missense_Mutation_p.P164S|C18orf1_uc002kse.2_Missense_Mutation_p.P145S|C18orf1_uc002ksf.2_Missense_Mutation_p.P127S|C18orf1_uc002ksg.1_Missense_Mutation_p.P105S|C18orf1_uc002ksh.1_Missense_Mutation_p.P124S|C18orf1_uc002ksi.1_Missense_Mutation_p.P106S	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	182	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		AGAGCCACCTCCTTACCAGGG	0.607													0	0	0	0.016522	0	23	225										T	13645279	C	T	13645279	3	4	86	1	0	0	0	0	1	0	0	0	1894	855	30	1	643	1	C18orf1	18	13645279	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	10752905	13645279	64431969	129	25649										
ASXL3	80816	broad.mit.edu	37	chr18	31326233	31326233	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ttacccaattagctgctcagAaaatgcaggtgcagcaacaa	8	10	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:31326233A>G	uc010dmg.1	+	12	6476	c.6421A>G	c.(6421-6423)AAA>GAA	p.K2141E	ASXL3_uc002kxq.2_Missense_Mutation_p.K1848E	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGCTGCTCAGAAAATGCAGGT	0.408													0	0	0	0.012213	0	34	83										G	31326233	A	G	31326233	3	3	86	1	0	0	0	0	1	0	0	0	1068	247	9	5	6467	5	ASXL3	18	31326233	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	17680954	31326233	46751015	130	25650										
MBD1	4152	broad.mit.edu	37	chr18	47802039	47802039	+	Frame_Shift_Del	DEL	G	G	-													0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cggggagggcgaaggcagatGgggcaatggccacaatcctc							TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:47802039delG	uc010dow.1	-	8	1160	c.723delC	c.(721-723)CCCfs	p.P241fs	MBD1_uc002lef.2_Frame_Shift_Del_p.P23fs|MBD1_uc002leg.2_Frame_Shift_Del_p.P192fs|MBD1_uc010xdi.1_Frame_Shift_Del_p.P267fs|MBD1_uc002leh.3_Frame_Shift_Del_p.P241fs|MBD1_uc002len.2_Frame_Shift_Del_p.P241fs|MBD1_uc002lei.3_Frame_Shift_Del_p.P241fs|MBD1_uc002lej.3_Frame_Shift_Del_p.P241fs|MBD1_uc002lek.3_Frame_Shift_Del_p.P192fs|MBD1_uc002lel.3_Frame_Shift_Del_p.P241fs|MBD1_uc002lem.3_Frame_Shift_Del_p.P241fs|MBD1_uc010xdj.1_Frame_Shift_Del_p.P241fs|MBD1_uc010xdk.1_Frame_Shift_Del_p.P241fs|MBD1_uc010dox.1_Frame_Shift_Del_p.P241fs|MBD1_uc002leo.2_Frame_Shift_Del_p.P241fs	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	241	CXXC-type 2.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAAGGCAGATGGGGCAATGGC	0.637																		8	48	---	---								-	47802039	G	-	47802039	7	5	86	1	0	1	0	1	0	0	0	0	9342	1335	47	0	1324	0	MBD1	18	47802039	Frame_Shift_Del	DEL	G	TCGA-FD-A3SR-01A-11D-A22Z-08	16475806	47802039	30275209	131	25651										
DCC	1630	broad.mit.edu	37	chr18	50976988	50976988	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acagtgctggtagtggtcatCgtggctgtgatttgcacccg	14	9	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:50976988C>T	uc002lfe.1	+	23	3935	c.3348C>T	c.(3346-3348)ATC>ATT	p.I1116I	DCC_uc010dpf.1_Silent_p.I751I	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1116	Helical; (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TAGTGGTCATCGTGGCTGTGA	0.512													0	0	0	0.008291	0	9	28										T	50976988	C	T	50976988	2	4	86	1	0	0	0	0	0	0	0	1	4282	874	31	1		1	DCC	18	50976988	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	3174949	50976988	27100260	132	25652										
NFATC1	4772	broad.mit.edu	37	chr18	77170646	77170646	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tcctcgcatcgagataacctCgtgcttgggcctgtaccaca	9	14	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr18:77170646C>T	uc010xfg.1	+	2	824	c.371C>T	c.(370-372)TCG>TTG	p.S124L	NFATC1_uc002lnc.1_Missense_Mutation_p.S124L|NFATC1_uc010xff.1_Missense_Mutation_p.S124L|NFATC1_uc002lnd.2_Missense_Mutation_p.S124L|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.S124L|NFATC1_uc010xfi.1_Missense_Mutation_p.S111L|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.S111L|NFATC1_uc002lng.2_Missense_Mutation_p.S111L|NFATC1_uc010xfk.1_Missense_Mutation_p.S111L	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	124					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GAGATAACCTCGTGCTTGGGC	0.627													0	0	0	0.004482	0	9	50										T	77170646	C	T	77170646	3	4	86	1	0	0	0	0	1	0	0	0	10361	893	31	1	469	1	NFATC1	18	77170646	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	26193658	77170646	906602	133	25653										
SH3GL1	6455	broad.mit.edu	37	chr19	4362650	4362650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgcaggggaagcccccgttgGactgctcaggctctccaagg	14	13	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:4362650G>A	uc002maj.2	-	8	918	c.812C>T	c.(811-813)TCC>TTC	p.S271F	SH3GL1_uc002mak.2_Missense_Mutation_p.S207F|SH3GL1_uc010xig.1_Missense_Mutation_p.S223F	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	271					central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		GCCCCCGTTGGACTGCTCAGG	0.642			T	MLL	AL								0	0	0	0.028581	0	16	54										A	4362650	G	A	4362650	3	1	86	1	0	0	0	0	1	0	0	0	14250	1174	41	1	306	1	SH3GL1	19	4362650	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		4362650	54766333	134	25654										
RANBP3	8498	broad.mit.edu	37	chr19	5931433	5931433	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	acctcaagtgcacacacctcAtcggcagcttcggaaggact	9	14	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:5931433A>T	uc002mdw.2	-	8	902	c.675T>A	c.(673-675)GAT>GAA	p.D225E	RANBP3_uc002mdv.2_5'UTR|RANBP3_uc002mdx.2_Missense_Mutation_p.D225E|RANBP3_uc002mdy.2_Missense_Mutation_p.D157E|RANBP3_uc002mdz.2_Missense_Mutation_p.D157E|RANBP3_uc010duq.2_Missense_Mutation_p.D135E|RANBP3_uc002mea.2_Missense_Mutation_p.D97E|RANBP3_uc010xix.1_Missense_Mutation_p.D97E	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	225					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						CACACACCTCATCGGCAGCTT	0.652													0	0	0	0.008871	0	20	27										T	5931433	A	T	5931433	3	4	86	1	0	0	0	0	1	0	0	0	13029	214	8	5	1068	5	RANBP3	19	5931433	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	1568783	5931433	53197550	135	25655										
ICAM5	7087	broad.mit.edu	37	chr19	10402336	10402336	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cttcgccggtgaaccaccccGagcgcggggcgcggtgctca	15	16	1	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:10402336G>A	uc002mnu.3	+	3	589	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	ICAM5_uc002mnv.3_Missense_Mutation_p.R50Q	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	175	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GAACCACCCCGAGCGCGGGGC	0.731													0	0	0	0.006214	0	10	54										A	10402336	G	A	10402336	3	1	86	1	0	0	0	0	1	0	0	0	7483	1058	37	1	534	1	ICAM5	19	10402336	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	4470903	10402336	48726647	136	25656										
UNC13A	23025	broad.mit.edu	37	chr19	17760337	17760337	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccaagtcgctcacgagtgggAtaggtttcctcttgcggatg	13	10	2	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:17760337A>G	uc002nhd.2	-	14	1763	c.1763T>C	c.(1762-1764)ATC>ACC	p.I588T		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	500					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						CACGAGTGGGATAGGTTTCCT	0.572													0	0	0	0.023175	0	38	83										G	17760337	A	G	17760337	3	3	86	1	0	0	0	0	1	0	0	0	16981	333	12	5	3732	5	UNC13A	19	17760337	Missense_Mutation	SNP	A	TCGA-FD-A3SR-01A-11D-A22Z-08	7358001	17760337	41368646	137	25657										
PSG1	5669	broad.mit.edu	37	chr19	43376193	43376193	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gagatggagggcttaggagtCtccactgtgcagaaaacagg	15	7	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:43376193C>G	uc002ovb.2	-	3	573	c.435G>C	c.(433-435)GAG>GAC	p.E145D	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Missense_Mutation_p.E145D|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Missense_Mutation_p.E145D|PSG1_uc010eio.1_Missense_Mutation_p.E145D|PSG1_uc002oux.1_Missense_Mutation_p.E74D|PSG1_uc002ouy.1_Missense_Mutation_p.E145D|PSG1_uc002ouz.1_Missense_Mutation_p.E145D|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Missense_Mutation_p.E145D	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	145					female pregnancy	extracellular region		p.E145G(1)		ovary(2)	2		Prostate(69;0.00682)				GCTTAGGAGTCTCCACTGTGC	0.522													0	0	0	0.024334	0	28	330										G	43376193	C	G	43376193	3	3	86	1	0	0	0	0	1	0	0	0	12653	912	32	1	893	1	PSG1	19	43376193	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	25615856	43376193	15752790	138	25658										
KLC3	147700	broad.mit.edu	37	chr19	45854218	45854218	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	tgccctctttgcagaatgaaGagagccatgtcactcaacac	8	12	3	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:45854218G>C	uc002pbf.1	+	12	1501	c.1386G>C	c.(1384-1386)AAG>AAC	p.K462N	KLC3_uc010ejy.1_Missense_Mutation_p.K461N|KLC3_uc002pbg.1_Missense_Mutation_p.K476N	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	462						cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GCAGAATGAAGAGAGCCATGT	0.552													0	0	0	0.006214	0	9	94										C	45854218	G	C	45854218	3	2	86	1	0	0	0	0	1	0	0	0	8335	933	33	1	1428	1	KLC3	19	45854218	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	2478025	45854218	13274765	139	25659										
PPP1R13L	10848	broad.mit.edu	37	chr19	45895561	45895561	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gtcagcagcccctctatctcCggctcaggctccagctcggt	10	17	4	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:45895561C>T	uc002pbn.2	-	8	1469	c.1392G>A	c.(1390-1392)CCG>CCA	p.P464P	PPP1R13L_uc002pbm.2_Silent_p.P43P|PPP1R13L_uc002pbo.2_Silent_p.P464P	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	464	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CCTCTATCTCCGGCTCAGGCT	0.647													0	0	0	0.016723	0	13	82										T	45895561	C	T	45895561	2	4	86	1	0	0	0	0	0	0	0	1	12358	639	23	2		2	PPP1R13L	19	45895561	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	41343	45895561	13233422	140	25660										
ZNF419	79744	broad.mit.edu	37	chr19	58005153	58005153	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	aatgtgggagattctttagaGagaattccaccctagttaga	10	6	1	4			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr19:58005153G>T	uc002qov.2	+	5	1468	c.1228G>T	c.(1228-1230)GAG>TAG	p.E410*	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Nonsense_Mutation_p.E411*|ZNF419_uc010etz.1_Nonsense_Mutation_p.E398*|ZNF419_uc010eua.1_Nonsense_Mutation_p.E397*|ZNF419_uc002qow.2_Nonsense_Mutation_p.E378*|ZNF419_uc010eub.1_Nonsense_Mutation_p.E365*|ZNF419_uc010euc.1_Nonsense_Mutation_p.E364*	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	410	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		ATTCTTTAGAGAGAATTCCAC	0.418													1	0	9.57634e-11	0.01892	1.03513e-10	24	120										T	58005153	G	T	58005153	4	4	86	1	0	0	0	0	0	1	0	0	17893	943	33	3	1249	3	ZNF419	19	58005153	Nonsense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08	12109592	58005153	1123830	141	25661										
REM1	28954	broad.mit.edu	37	chr20	30071976	30071976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccttagagggccgcgcctgcGctgtggtgttcgactgtaaa	14	11	0	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:30071976G>A	uc002wwa.2	+	5	924	c.640G>A	c.(640-642)GCT>ACT	p.A214T	NCRNA00028_uc010ztn.1_5'Flank	NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	214					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCGCGCCTGCGCTGTGGTGTT	0.617													0	0	0	0.013537	0	10	6										A	30071976	G	A	30071976	3	1	86	1	0	0	0	0	1	0	0	0	13222	1087	38	2	654	2	REM1	20	30071976	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		30071976	32953544	142	25662										
ZMYND8	23613	broad.mit.edu	37	chr20	45905274	45905274	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	cttgggggatgccgtcatgtCaaagttgagcttgaccttct	12	9	3	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:45905274C>G	uc002xta.1	-	11	1458	c.1204G>C	c.(1204-1206)GAC>CAC	p.D402H	ZMYND8_uc010ghq.1_Missense_Mutation_p.D79H|ZMYND8_uc010ghr.1_Missense_Mutation_p.D377H|ZMYND8_uc002xst.1_Missense_Mutation_p.D377H|ZMYND8_uc002xsu.1_Missense_Mutation_p.D402H|ZMYND8_uc002xsv.1_Missense_Mutation_p.D377H|ZMYND8_uc002xsw.1_Missense_Mutation_p.D154H|ZMYND8_uc002xsx.1_Missense_Mutation_p.D154H|ZMYND8_uc002xsy.1_Missense_Mutation_p.D377H|ZMYND8_uc002xsz.1_Missense_Mutation_p.D339H|ZMYND8_uc010zxy.1_Missense_Mutation_p.D429H|ZMYND8_uc002xtb.1_Missense_Mutation_p.D422H|ZMYND8_uc002xss.2_Missense_Mutation_p.D402H|ZMYND8_uc010zxz.1_Missense_Mutation_p.D397H|ZMYND8_uc002xtc.1_Missense_Mutation_p.D422H|ZMYND8_uc002xtd.1_Missense_Mutation_p.D397H|ZMYND8_uc002xte.1_Missense_Mutation_p.D402H|ZMYND8_uc010zya.1_Missense_Mutation_p.D402H|ZMYND8_uc002xtf.1_Missense_Mutation_p.D422H|ZMYND8_uc002xtg.2_Missense_Mutation_p.D396H|ZMYND8_uc010ghs.1_Missense_Mutation_p.D396H	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	402							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCCGTCATGTCAAAGTTGAGC	0.582													0	0	0	0.009718	0	40	133										G	45905274	C	G	45905274	3	3	86	1	0	0	0	0	1	0	0	0	17708	826	29	1	2354	1	ZMYND8	20	45905274	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	15833298	45905274	17120246	143	25663										
C20orf135	140701	broad.mit.edu	37	chr20	62493636	62493636	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggtggtctacggctggtctgTtggcggcttcacggccacct	15	12	3	0			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr20:62493636T>C	uc002ygx.1	+	1	1071	c.743T>C	c.(742-744)GTT>GCT	p.V248A	TPD52L2_uc002ygy.2_5'Flank|TPD52L2_uc002ygz.2_5'Flank|TPD52L2_uc002yha.2_5'Flank|TPD52L2_uc002yhb.2_5'Flank|TPD52L2_uc002yhc.2_5'Flank|TPD52L2_uc002yhd.2_5'Flank|TPD52L2_uc011abk.1_5'Flank|TPD52L2_uc011abl.1_5'Flank	NM_080622	NP_542189	Q9H3Z7	ABHGB_HUMAN	hypothetical protein LOC140701	248							hydrolase activity				0	all_cancers(38;1.77e-12)|all_epithelial(29;3.12e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					GGCTGGTCTGTTGGCGGCTTC	0.672													0	0	0	0.00308	0	7	18										C	62493636	T	C	62493636	3	2	86	1	0	0	0	0	1	0	0	0	2088	1725	60	5	745	5	C20orf135	20	62493636	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08	16588362	62493636	531884	144	25664										
PNPLA3	80339	broad.mit.edu	37	chr22	44333050	44333050	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ccccggagtcggctgccttgGctgtgaggctggagggagat	18	10	0	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chr22:44333050G>C	uc003bei.1	+	6	1050	c.877G>C	c.(877-879)GCT>CCT	p.A293P	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	293	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				GGCTGCCTTGGCTGTGAGGCT	0.617													0	0	0	0.006214	0	10	29										C	44333050	G	C	44333050	3	2	86	1	0	0	0	0	1	0	0	0	12166	1203	42	4	899	4	PNPLA3	22	44333050	Missense_Mutation	SNP	G	TCGA-FD-A3SR-01A-11D-A22Z-08		44333050	6971516	145	25665										
NLGN4X	57502	broad.mit.edu	37	chrX	6069450	6069450	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gaggacattggagtttaacaTgacgcagaccggggtgaaca	14	7	0	3			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrX:6069450T>A	uc010ndh.2	-	2	559	c.58A>T	c.(58-60)ATG>TTG	p.M20L	NLGN4X_uc004crp.2_Missense_Mutation_p.M20L|NLGN4X_uc004crq.2_Missense_Mutation_p.M20L|NLGN4X_uc010ndi.2_Missense_Mutation_p.M20L|NLGN4X_uc004crr.2_Missense_Mutation_p.M20L|NLGN4X_uc010ndj.2_Missense_Mutation_p.M20L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	20					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GAGTTTAACATGACGCAGACC	0.498													0	0	0	0.027356	0	25	13										A	6069450	T	A	6069450	3	1	86	1	0	0	0	0	1	0	0	0	10464	1464	51	5	2412	5	NLGN4X	23	6069450	Missense_Mutation	SNP	T	TCGA-FD-A3SR-01A-11D-A22Z-08		6069450	149201110	146	25666										
CXorf66	347487	broad.mit.edu	37	chrX	139038603	139038603	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	gcctttcttatgtgccttttCcaggtgagatgacttgctta	9	9	1	2			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrX:139038603C>T	uc004fbb.2	-	3	560	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	180	Cytoplasmic (Potential).					integral to membrane					0						TGTGCCTTTTCCAGGTGAGAT	0.413													0	0	0	0.01441	0	65	149										T	139038603	C	T	139038603	3	4	86	1	0	0	0	0	1	0	0	0	4118	864	30	1	551	1	CXorf66	23	139038603	Missense_Mutation	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08	132969153	139038603	16231957	147	25667										
PCDH11Y	83259	broad.mit.edu	37	chrY	4968004	4968004	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.283783783783784	42	1.3686381163582e-09	2.69611625514403	5.43387137137137	1.26939880020866	0.00170195563571023	0.00819460120897518	26	ggacagcctgattctctcttCagtgttgtaattgtcaatct	8	9	5	1			TCGA-FD-A3SR-01A-11D-A22Z-08	TCGA-FD-A3SR-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e8dea890-442e-4a02-936f-9bf2d284533b	da22f11e-a35b-469e-8de2-ded22821adab	g.chrY:4968004C>T	uc004fqo.2	+	2	3119	c.2385C>T	c.(2383-2385)TTC>TTT	p.F795F	PCDH11Y_uc010nwg.1_Silent_p.F784F|PCDH11Y_uc004fql.1_Silent_p.F784F|PCDH11Y_uc004fqm.1_Silent_p.F784F|PCDH11Y_uc004fqn.1_Silent_p.F795F|PCDH11Y_uc004fqp.1_Silent_p.F566F	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	795	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ATTCTCTCTTCAGTGTTGTAA	0.423													0	0	0	0.010729	0	8	130										T	4968004	C	T	4968004	2	4	86	1	0	0	0	0	0	0	0	1	11509	825	29	1		1	PCDH11Y	24	4968004	Silent	SNP	C	TCGA-FD-A3SR-01A-11D-A22Z-08		4968004	54405562	148	25668										
SAMD11	148398	broad.mit.edu	37	chr1	878746	878746	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggggcctgtctggctgtggaGagtacactcgggtaaggggg	20	7	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:878746G>C	uc001abw.1	+	12	1758	c.1678G>C	c.(1678-1680)GAG>CAG	p.E560Q	SAMD11_uc001abx.1_Missense_Mutation_p.E423Q	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	560	SAM.					nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGGCTGTGGAGAGTACACTCG	0.657													0	0	0	0.013537	0	11	37										C	878746	G	C	878746	3	2	87	1	0	0	0	0	1	0	0	0	13816	943	33	1	1720	1	SAMD11	1	878746	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		878746	248371875	1	25669										
AGRN	375790	broad.mit.edu	37	chr1	970701	970701	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagtgcctccgacgcctcctGatggtgagtagggctgagtt	14	11	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:970701G>A	uc001ack.1	+	3	558	c.508G>A	c.(508-510)GAT>AAT	p.D170N		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	170					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GACGCCTCCTGATGGTGAGTA	0.597													0	0	0	0.003954	0	22	113										A	970701	G	A	970701	3	1	87	1	0	0	0	0	1	0	0	0	397	1290	45	1	518	1	AGRN	1	970701	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	91955	970701	248279920	2	25670										
CCDC27	148870	broad.mit.edu	37	chr1	3672032	3672032	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	actctacaggttcacccactGaggccgatttgtccggagag	11	12	2	2	rs139820400		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:3672032G>A	uc001akv.2	+	3	535	c.454G>A	c.(454-456)GAG>AAG	p.E152K		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	152										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TTCACCCACTGAGGCCGATTT	0.552													0	0	0	0.01441	0	121	235										A	3672032	G	A	3672032	3	1	87	1	0	0	0	0	1	0	0	0	2801	1291	45	1	464	1	CCDC27	1	3672032	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2701331	3672032	245578589	3	25671										
CHD5	26038	broad.mit.edu	37	chr1	6181225	6181225	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcctctggccgctcctctcGggctctctccttgctggctg	10	18	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:6181225G>A	uc001amb.1	-	33	4952	c.4852C>T	c.(4852-4854)CGA>TGA	p.R1618*	CHD5_uc001alz.1_Nonsense_Mutation_p.R475*|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1618					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGCTCCTCTCGGGCTCTCTCC	0.647													0	0	0	0.001984	0	7	16										A	6181225	G	A	6181225	4	1	87	1	0	0	0	0	0	1	0	0	3328	1124	39	2	1048	2	CHD5	1	6181225	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2509193	6181225	243069396	4	25672										
ICMT	23463	broad.mit.edu	37	chr1	6291999	6291999	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtaaaaccacccgacgtaaGaaggatgccgaaaccaagcg	10	11	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:6291999G>A	uc001amk.2	-	4	708	c.635C>T	c.(634-636)TCT>TTT	p.S212F	ICMT_uc001aml.2_Missense_Mutation_p.S116F	NM_012405	NP_036537	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	212					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CCCGACGTAAGAAGGATGCCG	0.348													0	0	0	0.004656	0	22	47										A	6291999	G	A	6291999	3	1	87	1	0	0	0	0	1	0	0	0	7485	942	33	1	227	1	ICMT	1	6291999	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	110774	6291999	242958622	5	25673										
KIF1B	23095	broad.mit.edu	37	chr1	10335485	10335485	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccatttcttttcctttaataGagtaaaaagaagaagaaaac	5	6	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:10335485G>C	uc001aqx.3	+	11	1085	c.883_splice	c.e11-1	p.S295_splice	KIF1B_uc001aqv.3_Splice_Site_p.S289_splice|KIF1B_uc001aqw.3_Splice_Site_p.S289_splice|KIF1B_uc001aqy.2_Splice_Site_p.S295_splice|KIF1B_uc001aqz.2_Splice_Site_p.S295_splice|KIF1B_uc001ara.2_Splice_Site_p.S295_splice|KIF1B_uc001arb.2_Splice_Site_p.S295_splice	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TCCTTTAATAGAGTAAAAAGA	0.323													0	0	0	0.008291	0	11	66										C	10335485	G	C	10335485	5	2	87	1	0	0	0	0	0	0	1	0	8284	956	33	1	898	1	KIF1B	1	10335485	Splice_Site	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4043486	10335485	238915136	6	25674										
LOC440563	440563	broad.mit.edu	37	chr1	13183488	13183488	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggaggaggaggaggtacacGtgctgggaaactgtacatcc	17	7	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:13183488G>C	uc010obg.1	-	1	480	c.385C>G	c.(385-387)CGT>GGT	p.R129G		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	129						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						GGAGGTACACGTGCTGGGAAA	0.512													0	0	0	0.01441	0	58	291										C	13183488	G	C	13183488	3	2	87	1	0	0	0	0	1	0	0	0	8879	1145	40	4	500	4	LOC440563	1	13183488	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2848003	13183488	236067133	7	25675										
PADI4	23569	broad.mit.edu	37	chr1	17681136	17681136	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagtcacagtcaggggcaagGaatacccgctgggcaggatt	14	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:17681136G>A	uc001baj.2	+	11	1292	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	422					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CAGGGGCAAGGAATACCCGCT	0.572													0	0	0	0.010504	0	20	18										A	17681136	G	A	17681136	3	1	87	1	0	0	0	0	1	0	0	0	11380	1175	41	1	1306	1	PADI4	1	17681136	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4497648	17681136	231569485	8	25676										
PLA2G2E	30814	broad.mit.edu	37	chr1	20249137	20249137	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tctggtccaccggccagtggGagccaccgatgccgcagtaa	13	14	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:20249137G>C	uc001bct.1	-	2	210	c.152C>G	c.(151-153)TCC>TGC	p.S51C		NM_014589	NP_055404	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE precursor	51					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGGCCAGTGGGAGCCACCGAT	0.612													0	0	0	0.013537	0	13	80										C	20249137	G	C	20249137	3	2	87	1	0	0	0	0	1	0	0	0	11998	1174	41	1	288	1	PLA2G2E	1	20249137	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2568001	20249137	229001484	9	25677										
HSPG2	3339	broad.mit.edu	37	chr1	22178416	22178416	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gatgtacaggcgggagccacGaacctgggcagccgtgggca	17	11	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:22178416G>A	uc001bfj.2	-	54	6914	c.6874C>T	c.(6874-6876)CGT>TGT	p.R2292C	HSPG2_uc009vqd.2_Missense_Mutation_p.R2293C	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2292	Ig-like C2-type 8.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGGGAGCCACGAACCTGGGCA	0.672													0	0	0	0.001984	0	7	14										A	22178416	G	A	22178416	3	1	87	1	0	0	0	0	1	0	0	0	7430	1058	37	1	6477	1	HSPG2	1	22178416	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1929279	22178416	227072205	10	25678										
PTAFR	5724	broad.mit.edu	37	chr1	28477482	28477482	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgctgtaaacaatcgggaaGagagtgtatcggaactcaga	12	6	1	2	rs143590918		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:28477482G>T	uc001bpl.2	-	2	178	c.51C>A	c.(49-51)CTC>CTA	p.L17L	PTAFR_uc001bpm.3_Silent_p.L17L|PTAFR_uc009vte.2_Silent_p.L17L	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	17	Helical; Name=1; (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CAATCGGGAAGAGAGTGTATC	0.527													1	0	0.000673444	0.008291	0.0006841	8	49										T	28477482	G	T	28477482	2	4	87	1	0	0	0	0	0	0	0	1	12723	929	33	3		3	PTAFR	1	28477482	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6299066	28477482	220773139	11	25679										
DLGAP3	58512	broad.mit.edu	37	chr1	35331860	35331860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caccggcacgccccggccccGcaggggcttctttggtatcg	13	17	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:35331860G>A	uc001byc.2	-	10	2764	c.2764C>T	c.(2764-2766)CGG>TGG	p.R922W		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	922					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCCCGGCCCCGCAGGGGCTTC	0.716											OREG0013353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	11										A	35331860	G	A	35331860	3	1	87	1	0	0	0	0	1	0	0	0	4561	1086	38	2	179	2	DLGAP3	1	35331860	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6854378	35331860	213918761	12	25680										
TFAP2E	339488	broad.mit.edu	37	chr1	36056363	36056363	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcacagccgcaagagcatgCtgctggctgccaagtgagtg	14	11	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:36056363C>A	uc010ohy.1	+	6	1241	c.1033C>A	c.(1033-1035)CTG>ATG	p.L345M	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	345	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CAAGAGCATGCTGCTGGCTGC	0.612													1	0	0.00024832	0.009096	0.000253452	3	18										A	36056363	C	A	36056363	3	1	87	1	0	0	0	0	1	0	0	0	15788	796	28	4	1055	4	TFAP2E	1	36056363	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	724503	36056363	213194258	13	25681										
MACF1	23499	broad.mit.edu	37	chr1	39893741	39893741	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagaacagggtgtgctgtcaGaaaagatagactcattgcag	12	7	2	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:39893741G>A	uc010oiu.1	+	27	12036	c.11905G>A	c.(11905-11907)GAA>AAA	p.E3969K	MACF1_uc010ois.1_Missense_Mutation_p.E3467K|MACF1_uc001cda.1_Missense_Mutation_p.E3354K|MACF1_uc001cdc.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5534	Spectrin 8.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTGCTGTCAGAAAAGATAGA	0.498													0	0	0	0.000602	0	5	66										A	39893741	G	A	39893741	3	1	87	1	0	0	0	0	1	0	0	0	9144	943	33	1	16780	1	MACF1	1	39893741	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3837378	39893741	209356880	14	25682										
HIVEP3	59269	broad.mit.edu	37	chr1	42049173	42049173	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggctgggtggaggtggctgtCagcatggcggtccgctgtcc	19	10	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:42049173C>T	uc001cgz.3	-	4	2509	c.1296G>A	c.(1294-1296)CTG>CTA	p.L432L	HIVEP3_uc001cha.3_Silent_p.L432L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	432	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGTGGCTGTCAGCATGGCGG	0.617													0	0	0	0.003163	0	15	33										T	42049173	C	T	42049173	2	4	87	1	0	0	0	0	0	0	0	1	7188	813	29	1		1	HIVEP3	1	42049173	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2155432	42049173	207201448	15	25683										
MPL	4352	broad.mit.edu	37	chr1	43805111	43805111	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggtcccacggtcatacagctGattgccacagaaacctgctg	10	13	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:43805111G>A	uc001ciw.2	+	4	606	c.561G>A	c.(559-561)CTG>CTA	p.L187L	MPL_uc001civ.2_Silent_p.L187L|MPL_uc009vwr.2_Silent_p.L180L	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	187	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCATACAGCTGATTGCCACAG	0.577			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						0	0	0	0.007835	0	41	75										A	43805111	G	A	43805111	2	1	87	1	0	0	0	0	0	0	0	1	9730	1277	45	1		1	MPL	1	43805111	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1755938	43805111	205445510	16	25684										
NASP	4678	broad.mit.edu	37	chr1	46082055	46082055	+	Frame_Shift_Del	DEL	C	C	-													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcctggtggaggaggctcttCagtctccatggtgcgtattc							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:46082055delC	uc001coi.1	+	12	2171	c.2069delC	c.(2068-2070)TCAfs	p.S690fs	NASP_uc001coh.1_Frame_Shift_Del_p.S692fs|NASP_uc001coj.1_Frame_Shift_Del_p.S351fs|NASP_uc010olr.1_Frame_Shift_Del_p.S626fs|NASP_uc001col.1_Frame_Shift_Del_p.S198fs	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	690					blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GGAGGCTCTTCAGTCTCCATG	0.368																		79	129	---	---								-	46082055	C	-	46082055	7	5	87	1	0	1	0	1	0	0	0	0	10172	838	29	0	2192	0	NASP	1	46082055	Frame_Shift_Del	DEL	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2276944	46082055	203168566	17	25685										
IPP	3652	broad.mit.edu	37	chr1	46182672	46182672	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttcaatggtgttccctatctCagctccaacccatccacctg	5	16	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:46182672C>T	uc001cou.2	-	7	1471	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	IPP_uc001cos.3_Missense_Mutation_p.E402K	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	402	Kelch 3.					actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TTCCCTATCTCAGCTCCAACC	0.323													0	0	0	0.010729	0	11	98										T	46182672	C	T	46182672	3	4	87	1	0	0	0	0	1	0	0	0	7800	835	29	1	664	1	IPP	1	46182672	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	100617	46182672	203067949	18	25686										
CYP4A11	1579	broad.mit.edu	37	chr1	47406995	47406995	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agccactgcctgtgcaggtaGagctgaactgccttgatcag	12	11	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:47406995G>A	uc001cqp.3	-	1	162	c.111C>T	c.(109-111)CTC>CTT	p.L37L	CYP4A11_uc001cqq.2_Silent_p.L37L|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	37					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TGTGCAGGTAGAGCTGAACTG	0.602													0	0	0	0.001984	0	7	130										A	47406995	G	A	47406995	2	1	87	1	0	0	0	0	0	0	0	1	4183	929	33	1		1	CYP4A11	1	47406995	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1224323	47406995	201843626	19	25687										
FOXD2	2306	broad.mit.edu	37	chr1	47904552	47904552	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgctgcgtggcggggccgcgGcggcgggggatcccggcgct	22	13	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:47904552G>A	uc001crm.2	+	1	2864	c.745G>A	c.(745-747)GCG>ACG	p.A249T		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	249	Ala-rich.|Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		cggggccgcggcggcgggggA	0.617													0	0	0	0.008291	0	11	5										A	47904552	G	A	47904552	3	1	87	1	0	0	0	0	1	0	0	0	5997	1203	42	2	747	2	FOXD2	1	47904552	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	497557	47904552	201346069	20	25688										
LRP8	7804	broad.mit.edu	37	chr1	53755276	53755276	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcatcggagccatcaggacaCtcctcctcgccgtcacactt	7	17	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:53755276C>T	uc001cvi.1	-	3	472	c.330G>A	c.(328-330)GAG>GAA	p.E110E	LRP8_uc001cvh.1_Translation_Start_Site|LRP8_uc001cvk.1_Silent_p.E110E|LRP8_uc001cvj.1_Silent_p.E110E|LRP8_uc001cvl.1_Silent_p.E110E	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	110	LDL-receptor class A 2.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						CATCAGGACACTCCTCCTCGC	0.592													0	0	0	0.000602	0	5	14										T	53755276	C	T	53755276	2	4	87	1	0	0	0	0	0	0	0	1	8963	564	20	2		2	LRP8	1	53755276	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5850724	53755276	195495345	21	25689										
CDCP2	200008	broad.mit.edu	37	chr1	54606823	54606823	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccgatgttgaagtcggacttGaagaccacctgcagttcgtg	12	10	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:54606823G>C	uc001cwv.1	-	3	1559	c.711C>G	c.(709-711)TTC>TTG	p.F237L		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	237	CUB 2.					extracellular region				ovary(1)	1						AGTCGGACTTGAAGACCACCT	0.547													0	0	0	0.004482	0	8	48										C	54606823	G	C	54606823	3	2	87	1	0	0	0	0	1	0	0	0	3094	1281	45	1	646	1	CDCP2	1	54606823	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	851547	54606823	194643798	22	25690										
DAB1	1600	broad.mit.edu	37	chr1	57489208	57489208	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtggaagagggcttacctgaGggtacagcagcagtgccgaa	16	8	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:57489208G>A	uc001cys.1	-	13	1565	c.891C>T	c.(889-891)CCC>CCT	p.P297P	DAB1_uc001cyt.1_Silent_p.P295P|DAB1_uc001cyq.1_Silent_p.P295P|DAB1_uc001cyr.1_Silent_p.P211P|DAB1_uc009vzw.1_Silent_p.P279P|DAB1_uc009vzx.1_Silent_p.P297P	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	330					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GCTTACCTGAGGGTACAGCAG	0.493													0	0	0	0.001984	0	7	11										A	57489208	G	A	57489208	2	1	87	1	0	0	0	0	0	0	0	1	4217	987	35	2		2	DAB1	1	57489208	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2882385	57489208	191761413	23	25691										
C1orf87	127795	broad.mit.edu	37	chr1	60505607	60505607	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	accatttcaggagaacccctCttagaaaatctctgacaaag	6	11	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:60505607C>A	uc001czs.1	-	5	821	c.729G>T	c.(727-729)AAG>AAT	p.K243N		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	243							calcium ion binding			ovary(1)|breast(1)	2						GAGAACCCCTCTTAGAAAATC	0.408													1	0	4.35082e-09	0.010504	4.58658e-09	21	122										A	60505607	C	A	60505607	3	1	87	1	0	0	0	0	1	0	0	0	2064	912	32	3	943	3	C1orf87	1	60505607	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3016399	60505607	188745014	24	25692										
INADL	10207	broad.mit.edu	37	chr1	62237176	62237176	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggatcagaacatttcccatCagcaagcaattgcattatta	6	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:62237176C>T	uc001dab.2	+	6	712	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	INADL_uc009waf.1_Nonsense_Mutation_p.Q200*|INADL_uc001daa.2_Nonsense_Mutation_p.Q200*|INADL_uc001dad.3_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	200	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CATTTCCCATCAGCAAGCAAT	0.373													0	0	0	0.000602	0	5	59										T	62237176	C	T	62237176	4	4	87	1	0	0	0	0	0	1	0	0	7731	827	29	1	616	1	INADL	1	62237176	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1731569	62237176	187013445	25	25693										
INSL5	10022	broad.mit.edu	37	chr1	67266883	67266883	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	taggacagagaataaaaacaGagtgaaaatggagcccttca	10	6	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:67266883G>C	uc001dcw.2	-	1	57	c.22C>G	c.(22-24)CTG>GTG	p.L8V		NM_005478	NP_005469	Q9Y5Q6	INSL5_HUMAN	insulin-like 5 precursor	8						extracellular region	hormone activity				0						AATAAAAACAGAGTGAAAATG	0.418													0	0	0	0.009096	0	4	32										C	67266883	G	C	67266883	3	2	87	1	0	0	0	0	1	0	0	0	7769	933	33	1	393	1	INSL5	1	67266883	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5029707	67266883	181983738	26	25694										
C1orf173	127254	broad.mit.edu	37	chr1	75097549	75097549	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	actgttaatgtttggaagttGatatgaattcattctctgtg	9	4	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:75097549G>C	uc001dgg.2	-	7	886	c.667C>G	c.(667-669)CAA>GAA	p.Q223E	C1orf173_uc001dgi.3_Missense_Mutation_p.Q17E	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	223										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTTGGAAGTTGATATGAATTC	0.403													0	0	0	0.005524	0	37	48										C	75097549	G	C	75097549	3	2	87	1	0	0	0	0	1	0	0	0	2014	1299	45	1	3957	1	C1orf173	1	75097549	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7830666	75097549	174153072	27	25695										
USP33	23032	broad.mit.edu	37	chr1	78180315	78180315	+	Frame_Shift_Del	DEL	A	A	-													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttacctccatgaatacaaagAaagtcattatttgaaatagg							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:78180315delA	uc001dht.2	-	20	2639	c.2292delT	c.(2290-2292)TTTfs	p.F764fs	USP33_uc001dhs.2_Frame_Shift_Del_p.F485fs|USP33_uc001dhu.2_Frame_Shift_Del_p.F733fs|USP33_uc001dhv.2_Frame_Shift_Del_p.F569fs|USP33_uc001dhw.2_Frame_Shift_Del_p.F756fs	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	764	DUSP 1.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						GAATACAAAGAAAGTCATTAT	0.368																		43	82	---	---								-	78180315	A	-	78180315	7	5	87	1	0	1	0	1	0	0	0	0	17061	243	9	0	572	0	USP33	1	78180315	Frame_Shift_Del	DEL	A	TCGA-FD-A3SS-01A-12D-A22Z-08	3082766	78180315	171070306	28	25696										
EPHX4	253152	broad.mit.edu	37	chr1	92528691	92528691	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgacgcattcatggaggttGagatggctgaagtcacaaag	13	6	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:92528691G>A	uc001don.2	+	7	1041	c.937G>A	c.(937-939)GAG>AAG	p.E313K		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	313						integral to membrane	hydrolase activity			central_nervous_system(1)	1						CATGGAGGTTGAGATGGCTGA	0.418													0	0	0	0.01441	0	52	81										A	92528691	G	A	92528691	3	1	87	1	0	0	0	0	1	0	0	0	5182	1291	45	1	963	1	EPHX4	1	92528691	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	14348376	92528691	156721930	29	25697										
RPAP2	79871	broad.mit.edu	37	chr1	92799022	92799022	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgcatcgtacttgaaaagttGagtaaagtgtaagtatgtaa	10	4	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:92799022G>C	uc001dot.2	+	9	1639	c.1530G>C	c.(1528-1530)TTG>TTC	p.L510F	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	510						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TTGAAAAGTTGAGTAAAGTGT	0.333													0	0	0	0.001984	0	5	70										C	92799022	G	C	92799022	3	2	87	1	0	0	0	0	1	0	0	0	13542	1281	45	1	1564	1	RPAP2	1	92799022	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	270331	92799022	156451599	30	25698										
EVI5	7813	broad.mit.edu	37	chr1	93170221	93170221	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgaggttgctagaggctgatGaactcgacacaagagaagag	14	6	0	6			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:93170221G>A	uc001dox.2	-	3	372	c.362C>T	c.(361-363)TCA>TTA	p.S121L	EVI5_uc010otf.1_Missense_Mutation_p.S121L	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	121	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AGAGGCTGATGAACTCGACAC	0.363													0	0	0	0.006214	0	9	127										A	93170221	G	A	93170221	3	1	87	1	0	0	0	0	1	0	0	0	5289	1294	45	1	2134	1	EVI5	1	93170221	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	371199	93170221	156080400	31	25699										
SNX7	51375	broad.mit.edu	37	chr1	99161250	99161250	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgatagataaaatatctcaGagaatttataaggaagaaag	8	2	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:99161250G>C	uc010ouc.1	+	5	868	c.816G>C	c.(814-816)CAG>CAC	p.Q272H	SNX7_uc001dsa.2_Missense_Mutation_p.Q208H|SNX7_uc010oud.1_Missense_Mutation_p.Q217H	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	208					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		AAATATCTCAGAGAATTTATA	0.313													0	0	0	0.001168	0	6	93										C	99161250	G	C	99161250	3	2	87	1	0	0	0	0	1	0	0	0	14907	933	33	1	834	1	SNX7	1	99161250	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5991029	99161250	150089371	32	25700										
S1PR1	1901	broad.mit.edu	37	chr1	101704981	101704981	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagcgctatatcacaatgctGaaaatgaaactccacaacgg	8	10	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:101704981G>A	uc001dud.2	+	2	955	c.441G>A	c.(439-441)CTG>CTA	p.L147L	S1PR1_uc009weg.2_Silent_p.L147L	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	147	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						TCACAATGCTGAAAATGAAAC	0.557											OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	47	52										A	101704981	G	A	101704981	2	1	87	1	0	0	0	0	0	0	0	1	13793	1277	45	1		1	S1PR1	1	101704981	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2543731	101704981	147545640	33	25701										
STXBP3	6814	broad.mit.edu	37	chr1	109339276	109339276	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatttggacaggttgatccaGaatgtaaagatagaaaatga	10	3	0	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:109339276G>A	uc001dvy.2	+	15	1359	c.1284G>A	c.(1282-1284)CAG>CAA	p.Q428Q	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	428					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		GGTTGATCCAGAATGTAAAGA	0.353													0	0	0	0.001984	0	6	62										A	109339276	G	A	109339276	2	1	87	1	0	0	0	0	0	0	0	1	15353	933	33	1		1	STXBP3	1	109339276	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7634295	109339276	139911345	34	25702										
AKNAD1	254268	broad.mit.edu	37	chr1	109359687	109359687	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cacctcagattttatttcttCagtgctatcaaagtcacata	4	10	5	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:109359687C>T	uc001dwa.2	-	15	2631	c.2362G>A	c.(2362-2364)GAA>AAA	p.E788K	AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	788										ovary(3)	3						TTTATTTCTTCAGTGCTATCA	0.443													0	0	0	0.007291	0	30	56										T	109359687	C	T	109359687	3	4	87	1	0	0	0	0	1	0	0	0	464	835	29	1	156	1	AKNAD1	1	109359687	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	20411	109359687	139890934	35	25703										
GSTM3	2947	broad.mit.edu	37	chr1	110280351	110280351	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gttgtccaggtagctcttccAagtactgaggcttcagtttt	10	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:110280351A>T	uc001dyo.2	-	7	705	c.395T>A	c.(394-396)TTG>TAG	p.L132*	GSTM3_uc001dyp.2_Nonsense_Mutation_p.L129*|GSTM3_uc010ovv.1_Nonsense_Mutation_p.L132*	NM_000849	NP_000840	P21266	GSTM3_HUMAN	glutathione S-transferase mu 3	132	GST C-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding				0		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TAGCTCTTCCAAGTACTGAGG	0.433													0	0	0	0.01441	0	45	93										T	110280351	A	T	110280351	4	4	87	1	0	0	0	0	0	1	0	0	6839	131	5	5	294	5	GSTM3	1	110280351	Nonsense_Mutation	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	920664	110280351	138970270	36	25704										
CHIA	27159	broad.mit.edu	37	chr1	111862083	111862083	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagaaggccctcggcctgcaGagtgcaagtaagtgactgag	14	9	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:111862083G>A	uc001eas.2	+	11	1273	c.1170G>A	c.(1168-1170)CAG>CAA	p.Q390Q	CHIA_uc001ear.2_Silent_p.Q282Q|CHIA_uc001eaq.2_Silent_p.Q282Q|CHIA_uc009wgc.2_Silent_p.Q282Q|CHIA_uc001eat.2_Silent_p.Q229Q|CHIA_uc001eav.2_Silent_p.Q229Q|CHIA_uc001eau.2_Silent_p.Q229Q|CHIA_uc009wgd.2_Silent_p.Q229Q	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	390					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		TCGGCCTGCAGAGTGCAAGTA	0.542													0	0	0	0.003954	0	24	29										A	111862083	G	A	111862083	2	1	87	1	0	0	0	0	0	0	0	1	3342	933	33	1		1	CHIA	1	111862083	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1581732	111862083	137388538	37	25705										
PDE4DIP	9659	broad.mit.edu	37	chr1	144879302	144879302	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acgaataatcacttgtaactGagagggaccggacccggctc	11	11	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:144879302G>A	uc001elw.3	-	27	4439	c.4148C>T	c.(4147-4149)TCA>TTA	p.S1383L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1339L|PDE4DIP_uc001elv.3_Missense_Mutation_p.S390L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1383	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACTTGTAACTGAGAGGGACCG	0.502			T	PDGFRB	MPD								0	0	0	0.01441	0	58	220										A	144879302	G	A	144879302	3	1	87	1	0	0	0	0	1	0	0	0	11643	1294	45	1	2964	1	PDE4DIP	1	144879302	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	33017219	144879302	104371319	38	25706										
NBPF10	100132406	broad.mit.edu	37	chr1	145296564	145296564	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagcaccttgtccaaaagctCagcccaggtaaggtggccat	10	13	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:145296564C>G	uc001end.3	+	3	521	c.486C>G	c.(484-486)CTC>CTG	p.L162L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Silent_p.L162L|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	162											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCCAAAAGCTCAGCCCAGGTA	0.572													0	0	0	0.006122	0	13	228										G	145296564	C	G	145296564	2	3	87	1	0	0	0	0	0	0	0	1	10193	813	29	1		1	NBPF10	1	145296564	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	417262	145296564	103954057	39	25707										
HIST2H2AB	317772	broad.mit.edu	37	chr1	149859417	149859417	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaccagcgcgggacgagcgcGacttggccttagcgcgggcc	17	14	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:149859417G>C	uc001ete.2	-	1	50	c.50C>G	c.(49-51)TCG>TGG	p.S17W	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	17					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGACGAGCGCGACTTGGCCTT	0.622													0	0	0	0.014323	0	20	102										C	149859417	G	C	149859417	3	2	87	1	0	0	0	0	1	0	0	0	7177	1059	37	1	346	1	HIST2H2AB	1	149859417	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4562853	149859417	99391204	40	25708										
ZNF687	57592	broad.mit.edu	37	chr1	151262298	151262298	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggagtcgtcttcatcttcaGaagaggaggaagtacccagc	12	9	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:151262298G>A	uc001exq.2	+	6	2877	c.2779G>A	c.(2779-2781)GAA>AAA	p.E927K	ZNF687_uc009wmo.2_Missense_Mutation_p.E927K|ZNF687_uc009wmp.2_Missense_Mutation_p.E927K	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	927	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCATCTTCAGAAGAGGAGGA	0.667													0	0	0	0.004672	0	3	5										A	151262298	G	A	151262298	3	1	87	1	0	0	0	0	1	0	0	0	18089	943	33	1	2797	1	ZNF687	1	151262298	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1402881	151262298	97988323	41	25709										
SLC27A3	11000	broad.mit.edu	37	chr1	153748380	153748380	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggcgagcgggcagcgccggGagccggagatgcagcggccg	21	12	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:153748380G>A	uc001fcz.2	+	1	613	c.548G>A	c.(547-549)GGA>GAA	p.G183E	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	183					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCAGCGCCGGGAGCCGGAGAT	0.741													0	0	0	0.001168	0	5	15										A	153748380	G	A	153748380	3	1	87	1	0	0	0	0	1	0	0	0	14527	1174	41	1	550	1	SLC27A3	1	153748380	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2486082	153748380	95502241	42	25710										
CRTC2	200186	broad.mit.edu	37	chr1	153923847	153923847	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agcaaactcagggggctgagGggcacacggcggtggtgggg	21	8	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:153923847G>T	uc010ped.1	-	11	1363	c.1293C>A	c.(1291-1293)CCC>CCA	p.P431P	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Intron	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	431					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGGGCTGAGGGGCACACGGC	0.557													1	0	2.7689e-08	0.001984	2.90938e-08	7	24										T	153923847	G	T	153923847	2	4	87	1	0	0	0	0	0	0	0	1	3900	1219	43	4		4	CRTC2	1	153923847	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	175467	153923847	95326774	43	25711										
PMVK	10654	broad.mit.edu	37	chr1	154898934	154898934	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccgaaaccactggatgtcaGacactctccgtgtgtcactc	8	15	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:154898934G>A	uc001ffq.2	-	4	661	c.338C>T	c.(337-339)TCT>TTT	p.S113F		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	113					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGGATGTCAGACACTCTCCG	0.607													0	0	0	0.006122	0	18	20										A	154898934	G	A	154898934	3	1	87	1	0	0	0	0	1	0	0	0	12144	942	33	1	248	1	PMVK	1	154898934	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	975087	154898934	94351687	44	25712										
OR10R2	343406	broad.mit.edu	37	chr1	158450384	158450384	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tttatctgtgtttcttatctCtgcattctgaggactatcct	6	9	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:158450384C>T	uc010pik.1	+	1	717	c.717C>T	c.(715-717)CTC>CTT	p.L239L	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TTTCTTATCTCTGCATTCTGA	0.428													0	0	0	0.001855	0	14	118										T	158450384	C	T	158450384	2	4	87	1	0	0	0	0	0	0	0	1	10917	900	32	1		1	OR10R2	1	158450384	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3551450	158450384	90800237	45	25713										
AIM2	9447	broad.mit.edu	37	chr1	159035839	159035839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagattcagcatctaacacaCgtgaggcgctatttacctct	7	12	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:159035839C>T	uc001ftj.1	-	4	922	c.677G>A	c.(676-678)CGT>CAT	p.R226H		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	226	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					ATCTAACACACGTGAGGCGCT	0.393													0	0	0	0.01441	0	59	108										T	159035839	C	T	159035839	3	4	87	1	0	0	0	0	1	0	0	0	432	536	19	2	366	2	AIM2	1	159035839	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	585455	159035839	90214782	46	25714										
NCSTN	23385	broad.mit.edu	37	chr1	160318836	160318836	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccacgtagtagagaaagagGaggacctacagtgggtattg	14	6	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:160318836G>A	uc001fvx.2	+	3	362	c.238G>A	c.(238-240)GAG>AAG	p.E80K	NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.E60K|NCSTN_uc010pjf.1_Missense_Mutation_p.E80K|NCSTN_uc001fvz.2_5'Flank|NCSTN_uc010pjg.1_5'Flank	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	80	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGAGAAAGAGGAGGACCTACA	0.463													0	0	0	0.012319	0	22	68										A	160318836	G	A	160318836	3	1	87	1	0	0	0	0	1	0	0	0	10241	1175	41	1	248	1	NCSTN	1	160318836	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1282997	160318836	88931785	47	25715										
NCSTN	23385	broad.mit.edu	37	chr1	160319451	160319451	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctagtgtacagtgcccaaatGatgggtttggtaagtgtccc	12	8	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:160319451G>A	uc001fvx.2	+	4	551	c.427G>A	c.(427-429)GAT>AAT	p.D143N	NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.D123N|NCSTN_uc010pjf.1_Missense_Mutation_p.D143N|NCSTN_uc001fvz.2_5'Flank|NCSTN_uc010pjg.1_5'Flank	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	143	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCCCAAATGATGGGTTTGG	0.507													0	0	0	0.006122	0	18	25										A	160319451	G	A	160319451	3	1	87	1	0	0	0	0	1	0	0	0	10241	1290	45	1	441	1	NCSTN	1	160319451	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	615	160319451	88931170	48	25716										
DUSP12	11266	broad.mit.edu	37	chr1	161726695	161726695	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagaatagagtggatgaaatGaaaatattgcctgttttggg	12	2	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:161726695G>T	uc001gbo.2	+	6	992	c.981G>T	c.(979-981)ATG>ATT	p.M327I	DUSP12_uc001gbp.2_Missense_Mutation_p.M197I	NM_007240	NP_009171	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	327					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)	1	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TGGATGAAATGAAAATATTGC	0.388													1	0	4.14922e-12	0.004007	4.46197e-12	16	81										T	161726695	G	T	161726695	3	4	87	1	0	0	0	0	1	0	0	0	4812	1290	45	3	1003	3	DUSP12	1	161726695	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1407244	161726695	87523926	49	25717										
ALDH9A1	223	broad.mit.edu	37	chr1	165648806	165648806	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggtttgattcctttagctGacatctccatgatcttgcag	8	10	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:165648806G>T	uc001gdh.1	-	6	908	c.803C>A	c.(802-804)TCA>TAA	p.S268*	ALDH9A1_uc010pky.1_Nonsense_Mutation_p.S174*|ALDH9A1_uc010pkz.1_Nonsense_Mutation_p.S258*|ALDH9A1_uc010pla.1_Nonsense_Mutation_p.S174*	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	244					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TCCTTTAGCTGACATCTCCAT	0.413													1	0	3.65163e-15	0.00632	3.96004e-15	25	154										T	165648806	G	T	165648806	4	4	87	1	0	0	0	0	0	1	0	0	506	1294	45	3	777	3	ALDH9A1	1	165648806	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3922111	165648806	83601815	50	25718										
POGK	57645	broad.mit.edu	37	chr1	166810266	166810266	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagaagagattcagagccggGaactagaggacggcccggca	15	9	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:166810266G>A	uc001gdt.1	+	2	193	c.73G>A	c.(73-75)GAA>AAA	p.E25K	POGK_uc010ple.1_5'UTR|POGK_uc010plf.1_5'UTR	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	25	Potential.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TCAGAGCCGGGAACTAGAGGA	0.517													0	0	0	0.009718	0	45	88										A	166810266	G	A	166810266	3	1	87	1	0	0	0	0	1	0	0	0	12185	1175	41	1	75	1	POGK	1	166810266	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1161460	166810266	82440355	51	25719										
C1orf129	80133	broad.mit.edu	37	chr1	170959046	170959046	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caactgtgtgataacaattgTatgaaggatgttatgttgca	10	4	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:170959046T>C	uc001ghg.2	+	11	1060	c.930T>C	c.(928-930)TGT>TGC	p.C310C	C1orf129_uc009wvy.2_Silent_p.C117C|C1orf129_uc010plz.1_Silent_p.C310C	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	310							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATAACAATTGTATGAAGGATG	0.423													0	0	0	0.01441	0	65	108										C	170959046	T	C	170959046	2	2	87	1	0	0	0	0	0	0	0	1	1996	1644	57	5		5	C1orf129	1	170959046	Silent	SNP	T	TCGA-FD-A3SS-01A-12D-A22Z-08	4148780	170959046	78291575	52	25720										
C1orf129	80133	broad.mit.edu	37	chr1	170965666	170965666	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggtatgcccaggatgccctGagagttctgctgaattgttc	12	9	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:170965666G>C	uc001ghg.2	+	14	1486	c.1356G>C	c.(1354-1356)CTG>CTC	p.L452L	C1orf129_uc009wvy.2_Silent_p.L259L|C1orf129_uc010plz.1_Silent_p.L452L	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	452							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGGATGCCCTGAGAGTTCTGC	0.418													0	0	0	0.010504	0	20	109										C	170965666	G	C	170965666	2	2	87	1	0	0	0	0	0	0	0	1	1996	1277	45	1		1	C1orf129	1	170965666	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6620	170965666	78284955	53	25721										
KLHL20	27252	broad.mit.edu	37	chr1	173703360	173703360	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgggcattcgggcttttgctGacacacattcatgtcgtgag	12	9	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:173703360G>A	uc001gjc.2	+	3	711	c.532G>A	c.(532-534)GAC>AAC	p.D178N	KLHL20_uc010pmr.1_Intron|KLHL20_uc009wwf.2_Missense_Mutation_p.D160N|KLHL20_uc001gjd.2_Missense_Mutation_p.D178N	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	178	BACK.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GGCTTTTGCTGACACACATTC	0.463													0	0	0	0.001984	0	6	80										A	173703360	G	A	173703360	3	1	87	1	0	0	0	0	1	0	0	0	8375	1290	45	1	538	1	KLHL20	1	173703360	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2737694	173703360	75547261	54	25722										
PAPPA2	60676	broad.mit.edu	37	chr1	176681100	176681100	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggtagcctgaagaaagagGatgaggtttggctcaaagta	14	4	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:176681100G>A	uc001gkz.2	+	12	4945	c.3781G>A	c.(3781-3783)GAT>AAT	p.D1261N	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1261					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAAGAAAGAGGATGAGGTTTG	0.398													0	0	0	0.001984	0	6	78										A	176681100	G	A	176681100	3	1	87	1	0	0	0	0	1	0	0	0	11433	1174	41	1	3876	1	PAPPA2	1	176681100	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2977740	176681100	72569521	55	25723										
TOR1AIP1	26092	broad.mit.edu	37	chr1	179887135	179887135	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgaaaacgcggccttcaaaGatgtagccttagtcctgact	9	10	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:179887135G>C	uc001gnq.2	+	10	1731	c.1513G>C	c.(1513-1515)GAT>CAT	p.D505H		NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	505	Lumenal (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						GGCCTTCAAAGATGTAGCCTT	0.428													0	0	0	0.00308	0	8	140										C	179887135	G	C	179887135	3	2	87	1	0	0	0	0	1	0	0	0	16369	942	33	1	1551	1	TOR1AIP1	1	179887135	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3206035	179887135	69363486	56	25724										
APOBEC4	403314	broad.mit.edu	37	chr1	183616842	183616842	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccctttcttcttcttcttttCatctgcctccttgctacttg	3	15	6	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:183616842C>T	uc001gqn.2	-	2	1347	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron	NM_203454	NP_982279	Q8WW27	ABEC4_HUMAN	apolipoprotein B	359					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0						TTCTTCTTTTCATCTGCCTCC	0.408													0	0	0	0.00278	0	21	162										T	183616842	C	T	183616842	3	4	87	1	0	0	0	0	1	0	0	0	796	835	29	1	32	1	APOBEC4	1	183616842	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3729707	183616842	65633779	57	25725										
HMCN1	83872	broad.mit.edu	37	chr1	186082010	186082010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcaacaatgctgacctaggtGatacagccaattatacctgt	7	10	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:186082010G>A	uc001grq.1	+	72	11285	c.11056G>A	c.(11056-11058)GAT>AAT	p.D3686N		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3686	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGACCTAGGTGATACAGCCAA	0.403													0	0	0	0.008871	0	21	74										A	186082010	G	A	186082010	3	1	87	1	0	0	0	0	1	0	0	0	7220	1290	45	1	11342	1	HMCN1	1	186082010	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2465168	186082010	63168611	58	25726										
GPR37L1	9283	broad.mit.edu	37	chr1	202097339	202097339	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtggtgggcctgaccgtggtCtacgccttctgcaccctccc	12	16	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202097339C>T	uc001gxj.2	+	2	1164	c.1101C>T	c.(1099-1101)GTC>GTT	p.V367V		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	367	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						TGACCGTGGTCTACGCCTTCT	0.647													0	0	0	0.006214	0	9	113										T	202097339	C	T	202097339	2	4	87	1	0	0	0	0	0	0	0	1	6692	900	32	1		1	GPR37L1	1	202097339	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	16015329	202097339	47153282	59	25727										
KDM5B	10765	broad.mit.edu	37	chr1	202700976	202700976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catggagggggatacaacttCgtccagttgagaagggggag	17	6	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202700976C>T	uc001gyf.2	-	24	4117	c.4001G>A	c.(4000-4002)CGA>CAA	p.R1334Q	KDM5B_uc009xag.2_Missense_Mutation_p.R1370Q|KDM5B_uc001gyg.1_Missense_Mutation_p.R1176Q	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1334					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GATACAACTTCGTCCAGTTGA	0.408													0	0	0	0.001984	0	7	75										T	202700976	C	T	202700976	3	4	87	1	0	0	0	0	1	0	0	0	8134	884	31	1	649	1	KDM5B	1	202700976	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	603637	202700976	46549645	60	25728										
KDM5B	10765	broad.mit.edu	37	chr1	202703015	202703015	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcttccccaagagttgccatCtgaaaaagagttaacaatca	7	10	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202703015C>G	uc001gyf.2	-	23	3540	c.3424_splice	c.e23-1	p.M1142_splice	KDM5B_uc009xag.2_Splice_Site_p.M1178_splice|KDM5B_uc001gyg.1_Splice_Site_p.M984_splice	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B						negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GAGTTGCCATCTGAAAAAGAG	0.418													0	0	0	0.012319	0	20	143										G	202703015	C	G	202703015	5	3	87	1	0	0	0	0	0	0	1	0	8134	927	32	1	1231	1	KDM5B	1	202703015	Splice_Site	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2039	202703015	46547606	61	25729										
RBBP5	5929	broad.mit.edu	37	chr1	205070807	205070807	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cactctgaaggaagcaacaaGatcctgagaatctgttttta	8	8	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:205070807G>C	uc001hbu.1	-	6	683	c.553C>G	c.(553-555)CTT>GTT	p.L185V	RBBP5_uc010prd.1_Missense_Mutation_p.L220V|RBBP5_uc001hbv.1_Missense_Mutation_p.L185V|RBBP5_uc010pre.1_Missense_Mutation_p.L52V	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	185	WD 3.				histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			GAAGCAACAAGATCCTGAGAA	0.393													0	0	0	0.01441	0	59	122										C	205070807	G	C	205070807	3	2	87	1	0	0	0	0	1	0	0	0	13102	942	33	1	1099	1	RBBP5	1	205070807	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2367792	205070807	44179814	62	25730										
C4BPA	722	broad.mit.edu	37	chr1	207314612	207314612	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	actggtcagctccagcccctCaatgtaaaggtaactccagc	8	14	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:207314612C>T	uc001hfo.2	+	10	1629	c.1435C>T	c.(1435-1437)CAA>TAA	p.Q479*		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	479	Sushi 7.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCCAGCCCCTCAATGTAAAGG	0.463													0	0	0	0.008871	0	19	86										T	207314612	C	T	207314612	4	4	87	1	0	0	0	0	0	1	0	0	2249	827	29	1	1469	1	C4BPA	1	207314612	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2243805	207314612	41936009	63	25731										
EPRS	2058	broad.mit.edu	37	chr1	220208271	220208271	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttacctcagtatgttccatCagattagagccatataaccc	5	12	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:220208271C>T	uc001hly.1	-	3	486	c.216G>A	c.(214-216)CTG>CTA	p.L72L	EPRS_uc010puf.1_5'UTR|EPRS_uc001hlz.1_Silent_p.L72L|EPRS_uc009xdt.1_5'UTR	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	72					glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TATGTTCCATCAGATTAGAGC	0.363													0	0	0	0.01441	0	45	71										T	220208271	C	T	220208271	2	4	87	1	0	0	0	0	0	0	0	1	5191	813	29	1		1	EPRS	1	220208271	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	12893659	220208271	29042350	64	25732										
C1orf198	84886	broad.mit.edu	37	chr1	231004195	231004195	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctttcgctcccggtcgtccaGaggccggttcccgctcatga	11	16	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:231004195G>C	uc001hub.2	-	1	108	c.64C>G	c.(64-66)CTG>GTG	p.L22V	C1orf198_uc001huc.1_Intron|C1orf198_uc001hud.1_Intron	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	22											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CGGTCGTCCAGAGGCCGGTTC	0.567													0	0	0	0.001168	0	5	10										C	231004195	G	C	231004195	3	2	87	1	0	0	0	0	1	0	0	0	2026	933	33	1	935	1	C1orf198	1	231004195	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10795924	231004195	18246426	65	25733										
WDR64	128025	broad.mit.edu	37	chr1	241951319	241951319	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caaaaatatgaatatcctctGatatttgaccgggaaaagta	7	6	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:241951319G>A	uc001hzf.1	+	13	1656	c.1503G>A	c.(1501-1503)CTG>CTA	p.L501L	WDR64_uc001hzg.1_Silent_p.L414L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	948										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AATATCCTCTGATATTTGACC	0.358													0	0	0	0.005443	0	27	58										A	241951319	G	A	241951319	2	1	87	1	0	0	0	0	0	0	0	1	17312	1277	45	1		1	WDR64	1	241951319	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10947124	241951319	7299302	66	25734										
HNRNPU	3192	broad.mit.edu	37	chr1	245019785	245019785	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttttgaggaccgcatgttctGgtaggtctttcccctctact	9	11	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:245019785G>C	uc001iaz.1	-	10	2104	c.1886C>G	c.(1885-1887)CCA>CGA	p.P629R	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.P353R|HNRNPU_uc001iba.1_Missense_Mutation_p.P610R|HNRNPU_uc001ibb.1_Missense_Mutation_p.P317R	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	629					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CGCATGTTCTGGTAGGTCTTT	0.378													0	0	0	0.00278	0	20	137										C	245019785	G	C	245019785	3	2	87	1	0	0	0	0	1	0	0	0	7273	1348	47	4	611	4	HNRNPU	1	245019785	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3068466	245019785	4230836	67	25735										
CNST	163882	broad.mit.edu	37	chr1	246810440	246810440	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tttatttttcttcatctttaGagagtaaaacttgtctcggc	6	7	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:246810440G>A	uc001ibp.2	+	9	1316	c.938_splice	c.e9-1	p.E313_splice	CNST_uc001ibo.3_Splice_Site_p.E313_splice	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1						positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TTCATCTTTAGAGAGTAAAAC	0.383											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	16	75										A	246810440	G	A	246810440	5	1	87	1	0	0	0	0	0	0	1	0	3634	956	33	1	967	1	CNST	1	246810440	Splice_Site	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1790655	246810440	2440181	68	25736										
MYT1L	23040	broad.mit.edu	37	chr2	1906969	1906969	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgaggtcttggaatatttctCgagctccttggccaggttgg	13	9	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:1906969C>G	uc002qxe.2	-	14	2742	c.1915G>C	c.(1915-1917)GAG>CAG	p.E639Q	MYT1L_uc002qxd.2_Missense_Mutation_p.E637Q|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	639					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GAATATTTCTCGAGCTCCTTG	0.498													0	0	0	0.00308	0	8	81										G	1906969	C	G	1906969	3	3	87	1	0	0	0	0	1	0	0	0	10107	893	31	1	1693	1	MYT1L	2	1906969	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		1906969	241292404	69	25737										
MYT1L	23040	broad.mit.edu	37	chr2	1926917	1926917	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcatcctcagcgattttgccGaggtttaacaatgacttggc	10	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:1926917G>A	uc002qxe.2	-	10	1451	c.624C>T	c.(622-624)CTC>CTT	p.L208L	MYT1L_uc002qxd.2_Silent_p.L208L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	208					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CGATTTTGCCGAGGTTTAACA	0.423													0	0	0	0.007413	0	19	50										A	1926917	G	A	1926917	2	1	87	1	0	0	0	0	0	0	0	1	10107	1045	37	1		1	MYT1L	2	1926917	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	19948	1926917	241272456	70	25738										
KIDINS220	57498	broad.mit.edu	37	chr2	8870993	8870993	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctttttagattctcattctGaatagtggttgggttgggac	12	5	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:8870993G>A	uc002qzc.2	-	30	5355	c.5173C>T	c.(5173-5175)CAG>TAG	p.Q1725*	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.Q1626*|KIDINS220_uc002qzb.2_Nonsense_Mutation_p.Q579*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1725	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTCTCATTCTGAATAGTGGTT	0.463													0	0	0	0.010504	0	19	61										A	8870993	G	A	8870993	4	1	87	1	0	0	0	0	0	1	0	0	8271	1299	45	1	146	1	KIDINS220	2	8870993	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6944076	8870993	234328380	71	25739										
TAF1B	9014	broad.mit.edu	37	chr2	10045054	10045054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaacatttttagatttgcctCgttttccagacataactgaa	6	8	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:10045054C>T	uc002qzz.2	+	9	974	c.874C>T	c.(874-876)CGT>TGT	p.R292C	TAF1B_uc010exc.2_Missense_Mutation_p.R292C|TAF1B_uc002qzy.3_Missense_Mutation_p.R292C|TAF1B_uc010yja.1_Missense_Mutation_p.R37C|TAF1B_uc010exd.2_Missense_Mutation_p.R37C	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	292					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGATTTGCCTCGTTTTCCAGA	0.378													0	0	0	0.004482	0	8	136										T	10045054	C	T	10045054	3	4	87	1	0	0	0	0	1	0	0	0	15517	884	31	1	908	1	TAF1B	2	10045054	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1174061	10045054	233154319	72	25740										
APOB	338	broad.mit.edu	37	chr2	21233505	21233505	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcgattcctctcaaaatattCttgcaaggtctcaaaaaatg	5	9	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:21233505C>T	uc002red.2	-	26	6363	c.6235G>A	c.(6235-6237)GAA>AAA	p.E2079K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2079	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAAATATTCTTGCAAGGTC	0.343													0	0	0	0.012319	0	22	79										T	21233505	C	T	21233505	3	4	87	1	0	0	0	0	1	0	0	0	785	922	32	1	7472	1	APOB	2	21233505	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11188451	21233505	221965868	73	25741										
ITSN2	50618	broad.mit.edu	37	chr2	24483991	24483991	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atacctgtccatgaataggtGatacagatccaggggacaca	10	9	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24483991G>A	uc002rfe.2	-	22	2924	c.2666C>T	c.(2665-2667)TCA>TTA	p.S889L	ITSN2_uc002rff.2_Missense_Mutation_p.S862L|ITSN2_uc002rfg.2_Missense_Mutation_p.S889L	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	889					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGAATAGGTGATACAGATCC	0.343													0	0	0	0.012319	0	20	49										A	24483991	G	A	24483991	3	1	87	1	0	0	0	0	1	0	0	0	7927	1294	45	1	2554	1	ITSN2	2	24483991	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3250486	24483991	218715382	74	25742										
NCOA1	8648	broad.mit.edu	37	chr2	24896249	24896249	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttatagagaaatcaacaactGatgacgatgtacagaaatca	7	6	2	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24896249G>A	uc002rfk.2	+	5	529	c.271G>A	c.(271-273)GAT>AAT	p.D91N	NCOA1_uc010eye.2_Missense_Mutation_p.D91N|NCOA1_uc002rfi.2_5'UTR|NCOA1_uc002rfj.2_Missense_Mutation_p.D91N|NCOA1_uc002rfl.2_Missense_Mutation_p.D91N	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	91									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCAACAACTGATGACGATGT	0.348			T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.004656	0	24	103										A	24896249	G	A	24896249	3	1	87	1	0	0	0	0	1	0	0	0	10228	1290	45	1	281	1	NCOA1	2	24896249	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	412258	24896249	218303124	75	25743										
NCOA1	8648	broad.mit.edu	37	chr2	24896300	24896300	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caagtagtcaaggagtgataGaaaaggaatccttgggacct	12	6	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24896300G>C	uc002rfk.2	+	5	580	c.322G>C	c.(322-324)GAA>CAA	p.E108Q	NCOA1_uc010eye.2_Missense_Mutation_p.E108Q|NCOA1_uc002rfi.2_5'UTR|NCOA1_uc002rfj.2_Missense_Mutation_p.E108Q|NCOA1_uc002rfl.2_Missense_Mutation_p.E108Q	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	108									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGTGATAGAAAAGGAATC	0.338			T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.012213	0	30	105										C	24896300	G	C	24896300	3	2	87	1	0	0	0	0	1	0	0	0	10228	943	33	1	332	1	NCOA1	2	24896300	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	51	24896300	218303073	76	25744										
ASXL2	55252	broad.mit.edu	37	chr2	26029159	26029159	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agatgccctcttcacctctgGagtttgtgtgaagcattgca	10	10	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:26029159G>A	uc002rgs.2	-	3	412	c.191C>T	c.(190-192)TCC>TTC	p.S64F		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCACCTCTGGAGTTTGTGTG	0.388													0	0	0	0.000602	0	4	32										A	26029159	G	A	26029159	3	1	87	1	0	0	0	0	1	0	0	0	1067	1174	41	1	4156	1	ASXL2	2	26029159	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1132859	26029159	217170214	77	25745										
DPY30	84661	broad.mit.edu	37	chr2	32264363	32264363	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gttacctcaacgttgtctgtGagaccgtactcagagtgagg	12	9	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:32264363G>C	uc002roa.1	-	3	288	c.69C>G	c.(67-69)CTC>CTG	p.L23L	MEMO1_uc010ymv.1_RNA|DPY30_uc002rob.1_Silent_p.L23L	NM_032574	NP_115963	Q9C005	DPY30_HUMAN	dpy-30-like protein	23					endosome transport|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Set1C/COMPASS complex|trans-Golgi network	protein homodimerization activity				0	Acute lymphoblastic leukemia(172;0.155)					CGTTGTCTGTGAGACCGTACT	0.493													0	0	0	0.00499	0	16	112										C	32264363	G	C	32264363	2	2	87	1	0	0	0	0	0	0	0	1	4744	1277	45	1		1	DPY30	2	32264363	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6235204	32264363	210935010	78	25746										
VIT	5212	broad.mit.edu	37	chr2	36994259	36994259	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagaccacaaaagcctatcaGaggccacctattccagggac	9	13	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:36994259G>A	uc002rpl.2	+	7	731	c.510G>A	c.(508-510)CAG>CAA	p.Q170Q	VIT_uc010ynf.1_Intron|VIT_uc002rpm.2_Silent_p.Q163Q|VIT_uc010ezv.2_Silent_p.Q163Q|VIT_uc010ezw.2_Silent_p.Q163Q	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	170						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				AAGCCTATCAGAGGCCACCTA	0.468													0	0	0	0.006214	0	8	33										A	36994259	G	A	36994259	2	1	87	1	0	0	0	0	0	0	0	1	17168	933	33	1		1	VIT	2	36994259	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4729896	36994259	206205114	79	25747										
ARHGAP25	9938	broad.mit.edu	37	chr2	69045056	69045056	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gttaacaagatgagtgtggaCaacctggctactgtgattgg	13	6	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:69045056C>T	uc002seu.2	+	8	1294	c.930C>T	c.(928-930)GAC>GAT	p.D310D	ARHGAP25_uc010fdg.2_Silent_p.D311D|ARHGAP25_uc010yql.1_Silent_p.D271D|ARHGAP25_uc002sev.2_Silent_p.D304D|ARHGAP25_uc002sew.2_Silent_p.D303D|ARHGAP25_uc002sex.2_Silent_p.D304D|ARHGAP25_uc010fdh.1_RNA|ARHGAP25_uc002sey.2_Silent_p.D37D	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	310	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TGAGTGTGGACAACCTGGCTA	0.488													0	0	0	0.004656	0	27	37										T	69045056	C	T	69045056	2	4	87	1	0	0	0	0	0	0	0	1	874	477	17	2		2	ARHGAP25	2	69045056	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	32050797	69045056	174154317	80	25748										
TACR1	6869	broad.mit.edu	37	chr2	75280808	75280808	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cactggcccatagtgtgattCccactacggtgtatgcatag	10	11	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:75280808C>T	uc002sng.2	-	3	1244	c.659G>A	c.(658-660)GGA>GAA	p.G220E	TACR1_uc002snh.2_Missense_Mutation_p.G220E	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	220	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TAGTGTGATTCCCACTACGGT	0.552											OREG0014726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	44										T	75280808	C	T	75280808	3	4	87	1	0	0	0	0	1	0	0	0	15502	855	30	1	580	1	TACR1	2	75280808	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6235752	75280808	167918565	81	25749										
LRRTM1	347730	broad.mit.edu	37	chr2	80529917	80529917	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctgtgcgtactccgggctgGcgcactgcaagttgccatcg	13	14	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:80529917G>A	uc002sok.1	-	2	1298	c.1028C>T	c.(1027-1029)GCC>GTC	p.A343V	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	343	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CTCCGGGCTGGCGCACTGCAA	0.677										HNSCC(69;0.2)			0	0	0	0.00308	0	8	13										A	80529917	G	A	80529917	3	1	87	1	0	0	0	0	1	0	0	0	9039	1203	42	2	544	2	LRRTM1	2	80529917	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5249109	80529917	162669456	82	25750										
TGOLN2	10618	broad.mit.edu	37	chr2	85554310	85554310	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggtctggccgtccgcacccGacttattagggacatctttt	11	12	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:85554310G>A	uc010fgd.1	-	2	834	c.545C>T	c.(544-546)TCG>TTG	p.S182L	TGOLN2_uc002soz.2_Missense_Mutation_p.S182L|TGOLN2_uc002spa.2_RNA|TGOLN2_uc002spb.2_Missense_Mutation_p.S182L|TGOLN2_uc002spc.1_Missense_Mutation_p.S182L	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	182	Extracellular (Potential).|10.|14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						GTCCGCACCCGACTTATTAGG	0.592													0	0	0	0.01441	0	217	378										A	85554310	G	A	85554310	3	1	87	1	0	0	0	0	1	0	0	0	15833	1059	37	1	780	1	TGOLN2	2	85554310	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5024393	85554310	157645063	83	25751										
PTCD3	55037	broad.mit.edu	37	chr2	86364195	86364195	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtagagctggcaagtgccttCagcttacctatttgtgaggg	13	8	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:86364195C>T	uc002sqw.2	+	23	1977	c.1911C>T	c.(1909-1911)TTC>TTT	p.F637F	PTCD3_uc002sqx.1_Silent_p.F227F	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	637						mitochondrion	protein binding			ovary(1)	1						CAAGTGCCTTCAGCTTACCTA	0.438													0	0	0	0.004656	0	27	169										T	86364195	C	T	86364195	2	4	87	1	0	0	0	0	0	0	0	1	12729	825	29	1		1	PTCD3	2	86364195	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	809885	86364195	156835178	84	25752										
ACTR1B	10120	broad.mit.edu	37	chr2	98274919	98274919	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtccggacaacctcaaactCagccgaggtatggaagtcaa	10	11	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:98274919C>T	uc002syb.2	-	6	836	c.628G>A	c.(628-630)GAG>AAG	p.E210K		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	210						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						ACCTCAAACTCAGCCGAGGTA	0.617													0	0	0	0.004482	0	7	30										T	98274919	C	T	98274919	3	4	87	1	0	0	0	0	1	0	0	0	210	835	29	1	526	1	ACTR1B	2	98274919	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11910724	98274919	144924454	85	25753										
AFF3	3899	broad.mit.edu	37	chr2	100210735	100210735	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tatccagctgccacttgttaGaggatgccggttcagcctga	11	11	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:100210735G>A	uc002tag.2	-	14	1624	c.1388C>T	c.(1387-1389)TCT>TTT	p.S463F	AFF3_uc002taf.2_Missense_Mutation_p.S488F|AFF3_uc010fiq.1_Missense_Mutation_p.S463F|AFF3_uc010yvr.1_Missense_Mutation_p.S616F|AFF3_uc002tah.1_Missense_Mutation_p.S488F	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	463					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CCACTTGTTAGAGGATGCCGG	0.443													0	0	0	0.010818	0	32	214										A	100210735	G	A	100210735	3	1	87	1	0	0	0	0	1	0	0	0	358	942	33	1	2336	1	AFF3	2	100210735	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1935816	100210735	142988638	86	25754										
SEPT10	151011	broad.mit.edu	37	chr2	110332202	110332202	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	taagagatcaagtgtcttcaGagagtggcctgtcggtgaaa	13	6	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:110332202G>C	uc002tew.2	-	5	935	c.556C>G	c.(556-558)CTG>GTG	p.L186V	SEPT10_uc010ywu.1_Intron|SEPT10_uc002tex.2_Missense_Mutation_p.L163V|SEPT10_uc002tey.2_Missense_Mutation_p.L186V|SEPT10_uc010ywv.1_Missense_Mutation_p.L52V|SEPT10_uc002tev.1_5'UTR|SEPT10_uc010fjo.2_RNA	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	186					cell cycle|cell division	septin complex	GTP binding				0						AGTGTCTTCAGAGAGTGGCCT	0.383													0	0	0	0.007413	0	16	66										C	110332202	G	C	110332202	3	2	87	1	0	0	0	0	1	0	0	0	14060	933	33	1	836	1	SEPT10	2	110332202	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10121467	110332202	132867171	87	25755										
TMEM87B	84910	broad.mit.edu	37	chr2	112858208	112858208	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttttgctatagatatgccttCatgcccttaatagatgattc	6	8	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:112858208C>T	uc002thm.2	+	15	1755	c.1386C>T	c.(1384-1386)TTC>TTT	p.F462F		NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	462						integral to membrane					0						GATATGCCTTCATGCCCTTAA	0.274													0	0	0	0.00308	0	7	68										T	112858208	C	T	112858208	2	4	87	1	0	0	0	0	0	0	0	1	16208	825	29	1		1	TMEM87B	2	112858208	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2526006	112858208	130341165	88	25756										
EN1	2019	broad.mit.edu	37	chr2	119600601	119600601	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcagcgccaggccgttcttGatgcctgtggctttcttgat	12	11	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:119600601G>C	uc002tlm.2	-	2	2108	c.1092C>G	c.(1090-1092)ATC>ATG	p.I364M		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	364					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GGCCGTTCTTGATGCCTGTGG	0.587													0	0	0	0.00308	0	8	43										C	119600601	G	C	119600601	3	2	87	1	0	0	0	0	1	0	0	0	5109	1280	45	1	90	1	EN1	2	119600601	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6742393	119600601	123598772	89	25757										
CLASP1	23332	broad.mit.edu	37	chr2	122122825	122122825	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtggttggacagctctttcaGaaggtcagccaccaggtcag	13	10	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:122122825G>A	uc002tnc.2	-	35	4312	c.3922C>T	c.(3922-3924)CTG>TTG	p.L1308L	CLASP1_uc010yyv.1_Silent_p.L354L|CLASP1_uc002tmz.2_Silent_p.L393L|CLASP1_uc002tna.2_Silent_p.L354L|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Silent_p.L1249L|CLASP1_uc010yza.1_Silent_p.L1241L|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tmy.2_Silent_p.L144L|CLASP1_uc002tnf.2_Silent_p.L210L	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1308	Localization to kinetochores.|Interaction with PHLDB2 and RSN.|Potential.|Interaction with CLIP2 (By similarity).				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					AGCTCTTTCAGAAGGTCAGCC	0.572													0	0	0	0.004672	0	3	21										A	122122825	G	A	122122825	2	1	87	1	0	0	0	0	0	0	0	1	3454	933	33	1		1	CLASP1	2	122122825	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2522224	122122825	121076548	90	25758										
POTEF	728378	broad.mit.edu	37	chr2	130843513	130843513	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tagtcaggttttctgggaatCcgacatgagtacttctgtgc	11	8	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:130843513C>G	uc010fmh.2	-	15	2052	c.1652G>C	c.(1651-1653)GGA>GCA	p.G551A		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	551						cell cortex	ATP binding			skin(3)|ovary(2)	5						TTCTGGGAATCCGACATGAGT	0.398													0	0	0	0.013726	0	32	16										G	130843513	C	G	130843513	3	3	87	1	0	0	0	0	1	0	0	0	12265	855	30	1	1587	1	POTEF	2	130843513	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	8720688	130843513	112355860	91	25759										
LRP1B	53353	broad.mit.edu	37	chr2	141533803	141533803	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggtctgcccaccacagtttCttatctagaaaaaggaaaga	8	9	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:141533803C>T	uc002tvj.1	-	33	6336	c.5364G>A	c.(5362-5364)AAG>AAA	p.K1788K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1788	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCACAGTTTCTTATCTAGAA	0.338										TSP Lung(27;0.18)			0	0	0	0.00308	0	8	34										T	141533803	C	T	141533803	2	4	87	1	0	0	0	0	0	0	0	1	8955	912	32	1		1	LRP1B	2	141533803	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10690290	141533803	101665570	92	25760										
TANC1	85461	broad.mit.edu	37	chr2	160050867	160050867	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccagtctcaccttggccacGaggaagttgtcactctgctc	9	14	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:160050867G>C	uc002uag.2	+	17	3116	c.2842G>C	c.(2842-2844)GAG>CAG	p.E948Q	TANC1_uc010zcm.1_Missense_Mutation_p.E940Q|TANC1_uc010fom.1_Missense_Mutation_p.E754Q	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	948	ANK 2.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCTTGGCCACGAGGAAGTTGT	0.557													0	0	0	0.00308	0	6	75										C	160050867	G	C	160050867	3	2	87	1	0	0	0	0	1	0	0	0	15541	1059	37	1	2900	1	TANC1	2	160050867	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	18517064	160050867	83148506	93	25761										
MARCH7	64844	broad.mit.edu	37	chr2	160609027	160609027	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcaagtgcacaggaagtttGcagtatgtccaccaagactg	11	9	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:160609027G>C	uc002uax.2	+	6	1850	c.1728G>C	c.(1726-1728)TTG>TTC	p.L576F	MARCH7_uc010foq.2_Missense_Mutation_p.L576F|MARCH7_uc010zcn.1_Missense_Mutation_p.L520F|MARCH7_uc010for.2_Missense_Mutation_p.L538F|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	576	RING-CH-type.						ligase activity|zinc ion binding				0						CAGGAAGTTTGCAGTATGTCC	0.383													0	0	0	0.01441	0	48	121										C	160609027	G	C	160609027	3	2	87	1	0	0	0	0	1	0	0	0	9306	1310	46	4	1746	4	MARCH7	2	160609027	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	558160	160609027	82590346	94	25762										
DHRS9	10170	broad.mit.edu	37	chr2	169939910	169939910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgactggctgacactagagGactacagagaacctattgaa	10	9	0	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:169939910G>A	uc002uep.2	+	6	1889	c.385G>A	c.(385-387)GAC>AAC	p.D129N	DHRS9_uc002ueq.2_Missense_Mutation_p.D129N|DHRS9_uc010zdc.1_Missense_Mutation_p.D189N|DHRS9_uc010zdd.1_Missense_Mutation_p.D129N|DHRS9_uc010zde.1_Missense_Mutation_p.D129N	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	129					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						GACACTAGAGGACTACAGAGA	0.468													0	0	0	0.003163	0	16	119										A	169939910	G	A	169939910	3	1	87	1	0	0	0	0	1	0	0	0	4498	1174	41	1	391	1	DHRS9	2	169939910	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	9330883	169939910	73259463	95	25763										
KBTBD10	10324	broad.mit.edu	37	chr2	170366331	170366331	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagaggaactgcggctttacCaatccacccttcttcaggat	8	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:170366331C>T	uc002ueu.1	+	1	120	c.43C>T	c.(43-45)CAA>TAA	p.Q15*	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	15					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						GCGGCTTTACCAATCCACCCT	0.488													0	0	0	0.013114	0	47	102										T	170366331	C	T	170366331	4	4	87	1	0	0	0	0	0	1	0	0	7990	595	21	2	45	2	KBTBD10	2	170366331	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	426421	170366331	72833042	96	25764										
GAD1	2571	broad.mit.edu	37	chr2	171678617	171678617	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgtacgatacctggtgcggcGtggcccatggatgcaccaga	14	12	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:171678617G>A	uc002ugi.2	+	3	525	c.103G>A	c.(103-105)GTG>ATG	p.V35M	GAD1_uc002ugh.2_Missense_Mutation_p.V35M	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	35					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTGGTGCGGCGTGGCCCATGG	0.627													0	0	0	0.009096	0	4	12										A	171678617	G	A	171678617	3	1	87	1	0	0	0	0	1	0	0	0	6179	1145	40	2	109	2	GAD1	2	171678617	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1312286	171678617	71520756	97	25765										
PLEKHA3	65977	broad.mit.edu	37	chr2	179368594	179368594	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatctgaatcagaagatactCttccatccttctcttcctga	4	12	4	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179368594C>T	uc002umn.2	+	8	1281	c.883C>T	c.(883-885)CTT>TTT	p.L295F		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	295						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			AGAAGATACTCTTCCATCCTT	0.368													0	0	0	0.004482	0	9	63										T	179368594	C	T	179368594	3	4	87	1	0	0	0	0	1	0	0	0	12057	913	32	1	913	1	PLEKHA3	2	179368594	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	7689977	179368594	63830779	98	25766										
TTN	7273	broad.mit.edu	37	chr2	179421813	179421813	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccatcgaaagctggttgttgCcatgaaaggctgacagagtt	12	8	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179421813C>A	uc010zfg.1	-	279	80588	c.80364G>T	c.(80362-80364)TGG>TGT	p.W26788C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W20483C|TTN_uc010zfi.1_Missense_Mutation_p.W20416C|TTN_uc010zfj.1_Missense_Mutation_p.W20291C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27715							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTTGTTGCCATGAAAGGC	0.443													1	0	1.5739e-10	0.004007	1.67292e-10	15	17										A	179421813	C	A	179421813	3	1	87	1	0	0	0	0	1	0	0	0	16732	740	26	4	20043	4	TTN	2	179421813	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	53219	179421813	63777560	99	25767										
TTN	7273	broad.mit.edu	37	chr2	179641476	179641476	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggaagtgagttttttcttGaaaaatggtttctgttgttt	10	2	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179641476G>C	uc010zfg.1	-	28	5339	c.5115C>G	c.(5113-5115)TTC>TTG	p.F1705L	TTN_uc010zfh.1_Missense_Mutation_p.F1659L|TTN_uc010zfi.1_Missense_Mutation_p.F1659L|TTN_uc010zfj.1_Missense_Mutation_p.F1659L|TTN_uc002unb.2_Missense_Mutation_p.F1705L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1705							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTTTCTTGAAAAATGGTT	0.483													0	0	0	0.00308	0	8	57										C	179641476	G	C	179641476	3	2	87	1	0	0	0	0	1	0	0	0	16732	1281	45	1	106213	1	TTN	2	179641476	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	219663	179641476	63557897	100	25768										
ZNF804A	91752	broad.mit.edu	37	chr2	185803228	185803228	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttaccagagcaagcattattGatcccactagaaaaccatga	6	10	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:185803228G>A	uc002uph.2	+	4	3699	c.3105G>A	c.(3103-3105)TTG>TTA	p.L1035L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1035						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AAGCATTATTGATCCCACTAG	0.413													0	0	0	0.004878	0	40	65										A	185803228	G	A	185803228	2	1	87	1	0	0	0	0	0	0	0	1	18167	1281	45	1		1	ZNF804A	2	185803228	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6161752	185803228	57396145	101	25769										
WDR75	84128	broad.mit.edu	37	chr2	190338996	190338996	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agcaggatgaaaaactaaacGaaactttagagaatgagctg	10	5	0	3	rs116046757	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:190338996G>A	uc002uql.1	+	19	2194	c.2134G>A	c.(2134-2136)GAA>AAA	p.E712K	WDR75_uc002uqm.1_Missense_Mutation_p.E648K|WDR75_uc002uqn.1_Missense_Mutation_p.E490K|WDR75_uc002uqo.1_Missense_Mutation_p.E490K	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	712						nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAACTAAACGAAACTTTAGA	0.363													0	0	0	0.006214	0	10	133										A	190338996	G	A	190338996	3	1	87	1	0	0	0	0	1	0	0	0	17322	1059	37	1	2208	1	WDR75	2	190338996	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4535768	190338996	52860377	102	25770										
MYO1B	4430	broad.mit.edu	37	chr2	192275892	192275892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agacaagaaggctttataccCatctaggtattatggctttg	9	7	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:192275892C>T	uc010fsg.2	+	27	3122	c.2867C>T	c.(2866-2868)CCA>CTA	p.P956L	MYO1B_uc002usq.2_Missense_Mutation_p.P898L|MYO1B_uc002usr.2_Missense_Mutation_p.P956L|MYO1B_uc002usu.2_Missense_Mutation_p.P201L|MYO1B_uc002usv.2_Missense_Mutation_p.P72L	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	956						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GCTTTATACCCATCTAGGTAT	0.358													0	0	0	0.012319	0	21	95										T	192275892	C	T	192275892	3	4	87	1	0	0	0	0	1	0	0	0	10069	594	21	2	2969	2	MYO1B	2	192275892	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1936896	192275892	50923481	103	25771										
GTF3C3	9330	broad.mit.edu	37	chr2	197654765	197654765	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcctcatatatcatggctaGagtagagaatggctcataag	10	7	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:197654765G>A	uc002uts.2	-	5	655	c.565C>T	c.(565-567)CTA>TTA	p.L189L	GTF3C3_uc010zgu.1_Silent_p.L189L|GTF3C3_uc002utu.2_Silent_p.L189L	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	189	TPR 2.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						ATCATGGCTAGAGTAGAGAAT	0.403													0	0	0	0.010729	0	11	54										A	197654765	G	A	197654765	2	1	87	1	0	0	0	0	0	0	0	1	6874	933	33	1		1	GTF3C3	2	197654765	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5378873	197654765	45544608	104	25772										
FN1	2335	broad.mit.edu	37	chr2	216272903	216272903	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aacttggtccacagtcgtgtCaggaggggcatcaggcgcta	14	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:216272903C>T	uc002vfa.2	-	17	2712	c.2446G>A	c.(2446-2448)GAC>AAC	p.D816N	FN1_uc002vfb.2_Missense_Mutation_p.D816N|FN1_uc002vfc.2_Missense_Mutation_p.D816N|FN1_uc002vfd.2_Missense_Mutation_p.D816N|FN1_uc002vfe.2_Missense_Mutation_p.D816N|FN1_uc002vff.2_Missense_Mutation_p.D816N|FN1_uc002vfg.2_Missense_Mutation_p.D816N|FN1_uc002vfh.2_Missense_Mutation_p.D816N|FN1_uc002vfi.2_Missense_Mutation_p.D816N|FN1_uc002vfj.2_Missense_Mutation_p.D816N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	816	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACAGTCGTGTCAGGAGGGGCA	0.502													0	0	0	0.000602	0	5	80										T	216272903	C	T	216272903	3	4	87	1	0	0	0	0	1	0	0	0	5962	826	29	1	5107	1	FN1	2	216272903	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	18618138	216272903	26926470	105	25773										
SPHKAP	80309	broad.mit.edu	37	chr2	228881142	228881142	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctatggatttgacaagcgctCacggctgtgtctccacctct	9	13	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:228881142C>T	uc002vpq.2	-	7	4475	c.4428G>A	c.(4426-4428)GTG>GTA	p.V1476V	SPHKAP_uc002vpp.2_Silent_p.V1476V|SPHKAP_uc010zlx.1_Silent_p.V1476V	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1476						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACAAGCGCTCACGGCTGTGT	0.463													0	0	0	0.00333	0	23	107										T	228881142	C	T	228881142	2	4	87	1	0	0	0	0	0	0	0	1	15047	813	29	1		1	SPHKAP	2	228881142	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	12608239	228881142	14318231	106	25774										
SP100	6672	broad.mit.edu	37	chr2	231327168	231327168	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtcatcagcagtgaggactCtgaaggatccactgacgttg	12	9	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:231327168C>G	uc002vqt.2	+	10	1133	c.992C>G	c.(991-993)TCT>TGT	p.S331C	SP100_uc002vqs.2_Missense_Mutation_p.S331C|SP100_uc002vqu.1_Missense_Mutation_p.S331C|SP100_uc010zmb.1_Missense_Mutation_p.S331C|SP100_uc002vqq.1_Missense_Mutation_p.S331C|SP100_uc002vqr.1_Missense_Mutation_p.S306C|SP100_uc010zmc.1_Missense_Mutation_p.S306C|SP100_uc002vqv.1_Missense_Mutation_p.S295C	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	331					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTGAGGACTCTGAAGGATCC	0.502													0	0	0	0.00278	0	21	23										G	231327168	C	G	231327168	3	3	87	1	0	0	0	0	1	0	0	0	14960	913	32	1	1030	1	SP100	2	231327168	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2446026	231327168	11872205	107	25775										
CNTN6	27255	broad.mit.edu	37	chr3	1367574	1367574	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttgctctgggaatgtaaagCtagtggaaagccaaaccctt	10	9	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:1367574C>G	uc003boz.2	+	9	1289	c.1022C>G	c.(1021-1023)GCT>GGT	p.A341G	CNTN6_uc011asj.1_Missense_Mutation_p.A269G|CNTN6_uc003bpa.2_Missense_Mutation_p.A341G	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	341	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GAATGTAAAGCTAGTGGAAAG	0.398													0	0	0	0.006122	0	19	78										G	1367574	C	G	1367574	3	3	87	1	0	0	0	0	1	0	0	0	3645	797	28	4	1052	4	CNTN6	3	1367574	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		1367574	196654856	108	25776										
CNTN6	27255	broad.mit.edu	37	chr3	1414637	1414637	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtagccgatatcattgttaGaggtaagcataaatggtgaa	11	4	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:1414637G>C	uc003boz.2	+	14	2051	c.1784G>C	c.(1783-1785)AGA>ACA	p.R595T	CNTN6_uc011asj.1_Missense_Mutation_p.R523T|CNTN6_uc003bpa.2_Missense_Mutation_p.R595T	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	595					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATCATTGTTAGAGGTAAGCAT	0.353													0	0	0	0.001984	0	7	97										C	1414637	G	C	1414637	3	2	87	1	0	0	0	0	1	0	0	0	3645	942	33	1	1834	1	CNTN6	3	1414637	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	47063	1414637	196607793	109	25777										
LRRN1	57633	broad.mit.edu	37	chr3	3887485	3887485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctggattaactccaacaaaaCcaacatccgcttcatggagc	6	13	1	0	rs145675446	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:3887485C>T	uc003bpt.3	+	2	1921	c.1160C>T	c.(1159-1161)ACC>ATC	p.T387I	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	387	LRRCT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCCAACAAAACCAACATCCGC	0.493													0	0	0	0.007835	0	42	56										T	3887485	C	T	3887485	3	4	87	1	0	0	0	0	1	0	0	0	9034	507	18	2	1162	2	LRRN1	3	3887485	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2472848	3887485	194134945	110	25778										
BRPF1	7862	broad.mit.edu	37	chr3	9776368	9776368	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agctgccagaggtggtctatCgggagctggaacaggacacc	15	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:9776368C>A	uc003bse.2	+	2	943	c.544C>A	c.(544-546)CGG>AGG	p.R182R	BRPF1_uc003bsf.2_Silent_p.R182R|BRPF1_uc003bsg.2_Silent_p.R182R|BRPF1_uc011ati.1_Silent_p.R182R	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	182	Interaction with MYST3 and MYST4.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GGTGGTCTATCGGGAGCTGGA	0.557													1	0	1.80694e-10	0.009535	1.91745e-10	30	54										A	9776368	C	A	9776368	2	1	87	1	0	0	0	0	0	0	0	1	1520	875	31	3		3	BRPF1	3	9776368	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5888883	9776368	188246062	111	25779										
IL17RE	132014	broad.mit.edu	37	chr3	9945786	9945786	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagccttggtgtgtgcgagtCtggcactgttcccgctgttt	13	10	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:9945786C>T	uc003btu.2	+	4	336	c.219C>T	c.(217-219)GTC>GTT	p.V73V	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Silent_p.V73V|IL17RE_uc011atn.1_Intron|IL17RE_uc003btw.2_Silent_p.V73V|IL17RE_uc003btx.2_Intron|IL17RE_uc010hcq.2_Silent_p.V73V|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	73	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GTGTGCGAGTCTGGCACTGTT	0.532													0	0	0	0.01441	0	54	117										T	9945786	C	T	9945786	2	4	87	1	0	0	0	0	0	0	0	1	7643	900	32	1		1	IL17RE	3	9945786	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	169418	9945786	188076644	112	25780										
FANCD2	2177	broad.mit.edu	37	chr3	10084780	10084780	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggatctgcagcattgtgtttTgccatcacggttacaggctt	11	9	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:10084780T>G	uc003buw.2	+	12	1013	c.935T>G	c.(934-936)TTG>TGG	p.L312W	FANCD2_uc003bux.1_Missense_Mutation_p.L312W|FANCD2_uc003buy.1_Missense_Mutation_p.L312W	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	312	Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CATTGTGTTTTGCCATCACGG	0.428			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.012319	0	21	63										G	10084780	T	G	10084780	3	3	87	1	0	0	0	0	1	0	0	0	5665	1821	63	5	977	5	FANCD2	3	10084780	Missense_Mutation	SNP	T	TCGA-FD-A3SS-01A-12D-A22Z-08	138994	10084780	187937650	113	25781										
SLC6A1	6529	broad.mit.edu	37	chr3	11067485	11067485	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctggatgcggcaacccagatCttcttctcatacgggctggg	12	12	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:11067485C>T	uc010hdq.2	+	9	1287	c.876C>T	c.(874-876)ATC>ATT	p.I292I		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	292	Helical; Name=6; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CAACCCAGATCTTCTTCTCAT	0.517													0	0	0	0.006214	0	8	136										T	11067485	C	T	11067485	2	4	87	1	0	0	0	0	0	0	0	1	14673	903	32	1		1	SLC6A1	3	11067485	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	982705	11067485	186954945	114	25782										
RBMS3	27303	broad.mit.edu	37	chr3	29628627	29628627	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tatggttttgtagattttgaCagtcctgcagccgcacagaa	10	8	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:29628627C>G	uc003cel.2	+	4	560	c.330C>G	c.(328-330)GAC>GAG	p.D110E	RBMS3_uc003cek.2_Missense_Mutation_p.D110E|RBMS3_uc010hfq.2_Missense_Mutation_p.D110E|RBMS3_uc003cem.2_Missense_Mutation_p.D109E|RBMS3_uc010hfr.2_Missense_Mutation_p.D110E	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	110	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TAGATTTTGACAGTCCTGCAG	0.403													0	0	0	0.000602	0	5	50										G	29628627	C	G	29628627	3	3	87	1	0	0	0	0	1	0	0	0	13150	477	17	4	344	4	RBMS3	3	29628627	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	18561142	29628627	168393803	115	25783										
C3orf39	84892	broad.mit.edu	37	chr3	43122498	43122498	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acgaacaccggcttgggcatGaagcgcagggcagcagcagg	16	11	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:43122498G>A	uc003cmq.1	-	2	567	c.426C>T	c.(424-426)TTC>TTT	p.F142F	C3orf39_uc003cmr.1_Silent_p.F142F	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	142						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		GCTTGGGCATGAAGCGCAGGG	0.617													0	0	0	0.013537	0	11	95										A	43122498	G	A	43122498	2	1	87	1	0	0	0	0	0	0	0	1	2229	1281	45	1		1	C3orf39	3	43122498	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	13493871	43122498	154899932	116	25784										
ZDHHC3	51304	broad.mit.edu	37	chr3	45000761	45000761	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggaccacgaactccgcataGaggaccagaaaccaggtaac	10	12	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:45000761G>C	uc003cod.2	-	2	442	c.168C>G	c.(166-168)CTC>CTG	p.L56L	ZDHHC3_uc003cog.2_Silent_p.L56L|ZDHHC3_uc011bad.1_Silent_p.L56L	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	56	Helical; (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		ACTCCGCATAGAGGACCAGAA	0.537													0	0	0	0.004482	0	9	100										C	45000761	G	C	45000761	2	2	87	1	0	0	0	0	0	0	0	1	17613	929	33	1		1	ZDHHC3	3	45000761	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1878263	45000761	153021669	117	25785										
ZDHHC3	51304	broad.mit.edu	37	chr3	45000794	45000794	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggtaacgatggcacaggcGatgccacagccgtcacggat	13	12	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:45000794G>A	uc003cod.2	-	2	409	c.135C>T	c.(133-135)ATC>ATT	p.I45I	ZDHHC3_uc003cog.2_Silent_p.I45I|ZDHHC3_uc011bad.1_Silent_p.I45I	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	45	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		TGGCACAGGCGATGCCACAGC	0.537													0	0	0	0.003163	0	14	105										A	45000794	G	A	45000794	2	1	87	1	0	0	0	0	0	0	0	1	17613	1048	37	1		1	ZDHHC3	3	45000794	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	33	45000794	153021636	118	25786										
CCR3	1232	broad.mit.edu	37	chr3	46306895	46306895	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctggccatttcggacctgctCttcctcgtcacccttccatt	6	17	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:46306895C>G	uc003cpg.1	+	4	789	c.246C>G	c.(244-246)CTC>CTG	p.L82L	CCR3_uc003cpi.1_Silent_p.L82L|CCR3_uc003cpj.1_Silent_p.L82L|CCR3_uc003cpk.1_Silent_p.L103L|CCR3_uc010hjb.1_Silent_p.L100L|CCR3_uc003cpl.1_Silent_p.L115L	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	82	Helical; Name=2; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CGGACCTGCTCTTCCTCGTCA	0.498													0	0	0	0.013537	0	12	208										G	46306895	C	G	46306895	2	3	87	1	0	0	0	0	0	0	0	1	2942	900	32	1		1	CCR3	3	46306895	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1306101	46306895	151715535	119	25787										
USP4	7375	broad.mit.edu	37	chr3	49331930	49331930	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtggctgcccatatagcgctGatgcggaggaagtgcttgat	15	8	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:49331930G>A	uc003cwq.2	-	14	1872	c.1793C>T	c.(1792-1794)TCA>TTA	p.S598L	USP4_uc003cwo.2_Missense_Mutation_p.S310L|USP4_uc003cwp.2_Missense_Mutation_p.S328L|USP4_uc003cwr.2_Missense_Mutation_p.S551L	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	598					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ATATAGCGCTGATGCGGAGGA	0.527													0	0	0	0.004482	0	8	80										A	49331930	G	A	49331930	3	1	87	1	0	0	0	0	1	0	0	0	17068	1294	45	1	1134	1	USP4	3	49331930	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3025035	49331930	148690500	120	25788										
ACTR8	93973	broad.mit.edu	37	chr3	53902769	53902769	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccacacaaacgcagcccgctCtcgtaacatgcggacaccaa	7	17	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:53902769C>G	uc003dhd.2	-	13	1911	c.1852G>C	c.(1852-1854)GAG>CAG	p.E618Q	ACTR8_uc003dhb.2_Missense_Mutation_p.E323Q|ACTR8_uc003dhc.2_Missense_Mutation_p.E507Q	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	618					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		GCAGCCCGCTCTCGTAACATG	0.478													0	0	0	0.004482	0	9	44										G	53902769	C	G	53902769	3	3	87	1	0	0	0	0	1	0	0	0	217	922	32	1	26	1	ACTR8	3	53902769	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4570839	53902769	144119661	121	25789										
DNASE1L3	1776	broad.mit.edu	37	chr3	58183687	58183687	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctgcagccggcattgaagtCacccatgaaaatgaaattct	9	10	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58183687C>A	uc003djo.1	-	6	662	c.565G>T	c.(565-567)GAC>TAC	p.D189Y	DNASE1L3_uc011bfd.1_Missense_Mutation_p.D159Y|DNASE1L3_uc003djp.1_Missense_Mutation_p.D189Y|DNASE1L3_uc003djq.1_Missense_Mutation_p.D189Y	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	189					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		GCATTGAAGTCACCCATGAAA	0.512													1	0	2.32078e-09	0.003163	2.4546e-09	14	30										A	58183687	C	A	58183687	3	1	87	1	0	0	0	0	1	0	0	0	4663	826	29	3	364	3	DNASE1L3	3	58183687	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4280918	58183687	139838743	122	25790										
KCTD6	200845	broad.mit.edu	37	chr3	58486802	58486802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccccacagctcgagaccctCaaggcaattactttattgat	6	13	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58486802C>T	uc003dkj.3	+	3	274	c.157C>T	c.(157-159)CAA>TAA	p.Q53*	KCTD6_uc003dki.3_Nonsense_Mutation_p.Q53*|KCTD6_uc003dkk.3_Nonsense_Mutation_p.Q53*	NM_001128214	NP_001121686	Q8NC69	KCTD6_HUMAN	potassium channel tetramerisation domain	53	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		TCGAGACCCTCAAGGCAATTA	0.453													0	0	0	0.005524	0	40	77										T	58486802	C	T	58486802	4	4	87	1	0	0	0	0	0	1	0	0	8113	827	29	1	163	1	KCTD6	3	58486802	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	303115	58486802	139535628	123	25791										
NFKBIZ	64332	broad.mit.edu	37	chr3	101572646	101572646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtggcaggtggagcaggaaGaaagcaaattggcaaatatt	14	4	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:101572646G>C	uc003dvp.2	+	5	1391	c.1276G>C	c.(1276-1278)GAA>CAA	p.E426Q	NFKBIZ_uc003dvo.2_Missense_Mutation_p.E326Q|NFKBIZ_uc010hpo.2_Missense_Mutation_p.E326Q|NFKBIZ_uc003dvq.2_Missense_Mutation_p.E304Q	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	426	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						GGAGCAGGAAGAAAGCAAATT	0.403													0	0	0	0.013726	0	34	46										C	101572646	G	C	101572646	3	2	87	1	0	0	0	0	1	0	0	0	10383	943	33	1	1294	1	NFKBIZ	3	101572646	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	43085844	101572646	96449784	124	25792										
PHLDB2	90102	broad.mit.edu	37	chr3	111603414	111603414	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgcatgacaatgtctactctCttggagggctggaaggtcgg	14	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:111603414C>G	uc010hqa.2	+	2	901	c.490C>G	c.(490-492)CTT>GTT	p.L164V	PHLDB2_uc003dyc.2_Missense_Mutation_p.L191V|PHLDB2_uc003dyd.2_Missense_Mutation_p.L164V|PHLDB2_uc003dyg.2_Missense_Mutation_p.L164V|PHLDB2_uc003dyh.2_Missense_Mutation_p.L164V|PHLDB2_uc003dye.3_Missense_Mutation_p.L164V|PHLDB2_uc003dyf.3_Missense_Mutation_p.L164V	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	164						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGTCTACTCTCTTGGAGGGCT	0.542													0	0	0	0.014323	0	24	95										G	111603414	C	G	111603414	3	3	87	1	0	0	0	0	1	0	0	0	11852	913	32	1	577	1	PHLDB2	3	111603414	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10030768	111603414	86419016	125	25793										
PHLDB2	90102	broad.mit.edu	37	chr3	111603734	111603734	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagaaccagctgacacctctCagcttgcctccaagaaactc	7	15	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:111603734C>G	uc010hqa.2	+	2	1221	c.810C>G	c.(808-810)CTC>CTG	p.L270L	PHLDB2_uc003dyc.2_Silent_p.L297L|PHLDB2_uc003dyd.2_Silent_p.L270L|PHLDB2_uc003dyg.2_Silent_p.L270L|PHLDB2_uc003dyh.2_Silent_p.L270L|PHLDB2_uc003dye.3_Silent_p.L270L|PHLDB2_uc003dyf.3_Silent_p.L270L	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	270						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGACACCTCTCAGCTTGCCTC	0.478													0	0	0	0.001855	0	13	53										G	111603734	C	G	111603734	2	3	87	1	0	0	0	0	0	0	0	1	11852	813	29	1		1	PHLDB2	3	111603734	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	320	111603734	86418696	126	25794										
GAP43	2596	broad.mit.edu	37	chr3	115395213	115395213	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggcagccccccaggctccTgcatcctcagaggagaaggc	12	16	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:115395213T>C	uc003ebq.2	+	2	770	c.384T>C	c.(382-384)CCT>CCC	p.P128P	GAP43_uc003ebr.2_Silent_p.P164P	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	128					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		CCCAGGCTCCTGCATCCTCAG	0.602													0	0	0	0.00278	0	21	35										C	115395213	T	C	115395213	2	2	87	1	0	0	0	0	0	0	0	1	6235	1567	55	5		5	GAP43	3	115395213	Silent	SNP	T	TCGA-FD-A3SS-01A-12D-A22Z-08	3791479	115395213	82627217	127	25795										
ALDH1L1	10840	broad.mit.edu	37	chr3	125828793	125828793	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acactctgactcacctggccGagggacctgattcccgccgc	10	17	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:125828793G>A	uc003eim.1	-	20	2531	c.2341C>T	c.(2341-2343)CGG>TGG	p.R781W	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.R680W|ALDH1L1_uc003ein.1_Missense_Mutation_p.R316W	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	781	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TCACCTGGCCGAGGGACCTGA	0.597													0	0	0	0.010729	0	11	30										A	125828793	G	A	125828793	3	1	87	1	0	0	0	0	1	0	0	0	494	1057	37	1	383	1	ALDH1L1	3	125828793	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10433580	125828793	72193637	128	25796										
TMCC1	23023	broad.mit.edu	37	chr3	129546893	129546893	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcttcatcttgggtggcactCgaatctgctgcaggacacga	11	11	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:129546893C>T	uc003emz.3	-	4	830	c.329G>A	c.(328-330)CGA>CAA	p.R110Q	TMCC1_uc010htg.2_5'UTR	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	110						integral to membrane				skin(1)	1						GGGTGGCACTCGAATCTGCTG	0.552													0	0	0	0.013726	0	31	67										T	129546893	C	T	129546893	3	4	87	1	0	0	0	0	1	0	0	0	15989	884	31	1	1648	1	TMCC1	3	129546893	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3718100	129546893	68475537	129	25797										
COL6A6	131873	broad.mit.edu	37	chr3	130290033	130290033	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcaccgatggggaatcccatGatgctgataaactcaatgcc	9	11	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:130290033G>A	uc010htl.2	+	6	2804	c.2773G>A	c.(2773-2775)GAT>AAT	p.D925N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	925	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGAATCCCATGATGCTGATAA	0.567													0	0	0	0.001855	0	13	65										A	130290033	G	A	130290033	3	1	87	1	0	0	0	0	1	0	0	0	3703	1290	45	1	2795	1	COL6A6	3	130290033	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	743140	130290033	67732397	130	25798										
C3orf36	80111	broad.mit.edu	37	chr3	133647541	133647541	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctccaggccctgagggggcaGagagacacgtgagcactaac	14	12	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:133647541G>C	uc003epz.1	-	1	1116	c.107C>G	c.(106-108)TCT>TGT	p.S36C		NM_025041	NP_079317	Q3SXR2	CC036_HUMAN	hypothetical protein LOC80111	36										ovary(1)	1						TGAGGGGGCAGAGAGACACGT	0.587													0	0	0	0.010729	0	12	50										C	133647541	G	C	133647541	3	2	87	1	0	0	0	0	1	0	0	0	2226	942	33	1	394	1	C3orf36	3	133647541	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3357508	133647541	64374889	131	25799										
ZBTB38	253461	broad.mit.edu	37	chr3	141163197	141163197	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcagagggtaccaaatgggGagaggaggcattgaaaatgg	17	4	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:141163197G>T	uc003etw.2	+	8	2949	c.1967G>T	c.(1966-1968)GGA>GTA	p.G656V	ZBTB38_uc010hun.2_Missense_Mutation_p.G653V|ZBTB38_uc010huo.2_Missense_Mutation_p.G656V|ZBTB38_uc003ety.2_Missense_Mutation_p.G656V|ZBTB38_uc010hup.2_Missense_Mutation_p.G657V	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	656					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						ACCAAATGGGGAGAGGAGGCA	0.468													1	0	1.00905e-13	0.008871	1.08875e-13	20	119										T	141163197	G	T	141163197	3	4	87	1	0	0	0	0	1	0	0	0	17536	1174	41	3	1969	3	ZBTB38	3	141163197	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7515656	141163197	56859233	132	25800										
HPS3	84343	broad.mit.edu	37	chr3	148868438	148868438	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtgcggcggcagctcgtgagGaggacccgtacatggacacc	16	12	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:148868438G>A	uc003ewu.1	+	6	1356	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K	HPS3_uc003ewt.1_Missense_Mutation_p.E406K|HPS3_uc011bnq.1_Missense_Mutation_p.E241K	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	406						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGCTCGTGAGGAGGACCCGTA	0.512									Hermansky-Pudlak_syndrome				0	0	0	0.008291	0	11	59										A	148868438	G	A	148868438	3	1	87	1	0	0	0	0	1	0	0	0	7340	1175	41	1	1238	1	HPS3	3	148868438	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7705241	148868438	49153992	133	25801										
TRIM59	286827	broad.mit.edu	37	chr3	160156793	160156793	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagcaatttcagtaatacttCtgcaattagggcacttgagt	9	7	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:160156793C>T	uc003fdm.2	-	3	374	c.179G>A	c.(178-180)AGA>AAA	p.R60K	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	60	RING-type.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGTAATACTTCTGCAATTAGG	0.358													0	0	0	0.008871	0	20	89										T	160156793	C	T	160156793	3	4	87	1	0	0	0	0	1	0	0	0	16529	913	32	1	1036	1	TRIM59	3	160156793	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11288355	160156793	37865637	134	25802										
ATP11B	23200	broad.mit.edu	37	chr3	182577088	182577088	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggatcttgatctgtatcatGaagaatcagatcagaaagct	10	6	5	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:182577088G>A	uc003flb.2	+	12	1398	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K		NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	381	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TCTGTATCATGAAGAATCAGA	0.328													0	0	0	0.004007	0	16	22										A	182577088	G	A	182577088	3	1	87	1	0	0	0	0	1	0	0	0	1120	1291	45	1	1187	1	ATP11B	3	182577088	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	22420295	182577088	15445342	135	25803										
HTR3E	285242	broad.mit.edu	37	chr3	183824447	183824447	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctgctcttcatggcctcctCtatcatcaccgtcatatgcc	5	17	6	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:183824447C>G	uc010hxq.2	+	9	1803	c.1337C>G	c.(1336-1338)TCT>TGT	p.S446C	HTR3E_uc003fml.3_Missense_Mutation_p.S431C|HTR3E_uc003fmm.2_Missense_Mutation_p.S461C|HTR3E_uc010hxr.2_Missense_Mutation_p.S472C|HTR3E_uc003fmn.2_Missense_Mutation_p.S446C	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	446	Helical; Name=4; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATGGCCTCCTCTATCATCACC	0.592													0	0	0	0.010818	0	32	83										G	183824447	C	G	183824447	3	3	87	1	0	0	0	0	1	0	0	0	7448	913	32	1	1412	1	HTR3E	3	183824447	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1247359	183824447	14197983	136	25804										
LPP	4026	broad.mit.edu	37	chr3	188327169	188327169	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caccacggcctccacttcttCaaggcctacctttaatgtgc	6	16	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:188327169C>T	uc003frs.1	+	6	896	c.650C>T	c.(649-651)TCA>TTA	p.S217L	LPP_uc011bsg.1_Missense_Mutation_p.S217L|LPP_uc011bsi.1_Missense_Mutation_p.S217L|LPP_uc003frt.2_Missense_Mutation_p.S217L|LPP_uc011bsj.1_Missense_Mutation_p.S54L	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	217	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TCCACTTCTTCAAGGCCTACC	0.592			T	HMGA2|MLL|C12orf9	lipoma|leukemia								0	0	0	0.010729	0	12	91										T	188327169	C	T	188327169	3	4	87	1	0	0	0	0	1	0	0	0	8923	838	29	1	664	1	LPP	3	188327169	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4502722	188327169	9695261	137	25805										
GP5	2814	broad.mit.edu	37	chr3	194117344	194117344	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttggtttacccaagggctctCtctctgattaattttcgaaa	7	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:194117344C>T	uc003ftv.1	-	2	1699	c.1668G>A	c.(1666-1668)GAG>GAA	p.E556E		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	556	Cytoplasmic (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CAAGGGCTCTCTCTCTGATTA	0.413													0	0	0	0.006999	0	38	186										T	194117344	C	T	194117344	2	4	87	1	0	0	0	0	0	0	0	1	6583	912	32	1		1	GP5	3	194117344	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5790175	194117344	3905086	138	25806										
CPLX1	10815	broad.mit.edu	37	chr4	780459	780459	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggcggcctgggcctcggcctCgcgctcctccttcttcttga	12	17	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:780459C>T	uc003gbi.2	-	4	426	c.235G>A	c.(235-237)GAG>AAG	p.E79K	CPLX1_uc003gbj.2_Missense_Mutation_p.E58K	NM_006651	NP_006642	O14810	CPLX1_HUMAN	complexin 1	79					glutamate secretion	cytosol					0				Colorectal(103;0.187)		GCCTCGGCCTCGCGCTCCTCC	0.756													0	0	0	0.001855	0	13	13										T	780459	C	T	780459	3	4	87	1	0	0	0	0	1	0	0	0	3804	893	31	1	173	1	CPLX1	4	780459	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		780459	190373817	139	25807										
TMEM175	84286	broad.mit.edu	37	chr4	947001	947001	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgattgtggggtacgcattCcacttcccgcacctgctgag	11	13	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:947001C>A	uc003gbq.2	+	8	584	c.486C>A	c.(484-486)TTC>TTA	p.F162L	TMEM175_uc010ibl.1_Missense_Mutation_p.F162L|TMEM175_uc003gbp.1_Missense_Mutation_p.F80L|TMEM175_uc003gbr.2_Missense_Mutation_p.F80L|TMEM175_uc003gbu.2_Missense_Mutation_p.F80L|TMEM175_uc003gbs.2_Missense_Mutation_p.F45L|TMEM175_uc003gbt.2_Missense_Mutation_p.F45L|TMEM175_uc003gbv.2_Missense_Mutation_p.F45L|TMEM175_uc010ibm.2_Intron	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	162						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGTACGCATTCCACTTCCCGC	0.657													1	0	0.00909568	0.009096	0.00918149	4	25										A	947001	C	A	947001	3	1	87	1	0	0	0	0	1	0	0	0	16088	854	30	3	512	3	TMEM175	4	947001	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	166542	947001	190207275	140	25808										
EVC	2121	broad.mit.edu	37	chr4	5749989	5749989	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctctgacggaaagaatgattGcagccgaagggctattgtgc	13	8	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:5749989G>T	uc003gil.1	+	8	1238	c.1054G>T	c.(1054-1056)GCA>TCA	p.A352S	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Missense_Mutation_p.Q472K	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	352					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				AAGAATGATTGCAGCCGAAGG	0.488													1	0	1.42536e-11	0.004656	1.52768e-11	25	11										T	5749989	G	T	5749989	3	4	87	1	0	0	0	0	1	0	0	0	5285	1319	46	4	1084	4	EVC	4	5749989	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4802988	5749989	185404287	141	25809										
DRD5	1816	broad.mit.edu	37	chr4	9783854	9783854	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtgtgcgcagccatcgtgcgGagccgccacctgcgcgccaa	14	16	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:9783854G>A	uc003gmb.3	+	1	597	c.201G>A	c.(199-201)CGG>CGA	p.R67R		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	67	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCATCGTGCGGAGCCGCCACC	0.647													0	0	0	0.008291	0	10	8										A	9783854	G	A	9783854	2	1	87	1	0	0	0	0	0	0	0	1	4760	1161	41	1		1	DRD5	4	9783854	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4033865	9783854	181370422	142	25810										
DRD5	1816	broad.mit.edu	37	chr4	9783920	9783920	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctggccgtgtcagaccttttCgtggcgctgctggtcatgcc	13	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:9783920C>T	uc003gmb.3	+	1	663	c.267C>T	c.(265-267)TTC>TTT	p.F89F		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	89	Helical; Name=2; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CAGACCTTTTCGTGGCGCTGC	0.632													0	0	0	0.008871	0	19	17										T	9783920	C	T	9783920	2	4	87	1	0	0	0	0	0	0	0	1	4760	883	31	1		1	DRD5	4	9783920	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	66	9783920	181370356	143	25811										
LDB2	9079	broad.mit.edu	37	chr4	16590352	16590352	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catgcatggctaggatgcttCtcgggactaactctcggtat	11	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:16590352C>G	uc003goz.2	-	4	828	c.512G>C	c.(511-513)AGA>ACA	p.R171T	LDB2_uc003gpa.2_Missense_Mutation_p.R171T|LDB2_uc003gpb.2_Missense_Mutation_p.R171T|LDB2_uc011bxh.1_Missense_Mutation_p.R171T|LDB2_uc010iee.2_Missense_Mutation_p.R171T|LDB2_uc003goy.2_Missense_Mutation_p.R47T|LDB2_uc011bxi.1_Missense_Mutation_p.R47T	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	171							LIM domain binding|transcription cofactor activity				0						TAGGATGCTTCTCGGGACTAA	0.393													0	0	0	0.001168	0	6	62										G	16590352	C	G	16590352	3	3	87	1	0	0	0	0	1	0	0	0	8696	913	32	1	738	1	LDB2	4	16590352	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6806432	16590352	174563924	144	25812										
KCTD8	386617	broad.mit.edu	37	chr4	44176909	44176909	+	Frame_Shift_Del	DEL	C	C	-													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaatcctgaatacactttttCatttcttcttccacacttag							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:44176909delC	uc003gwu.2	-	2	1604	c.1320delG	c.(1318-1320)ATGfs	p.M440fs		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	440						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TACACTTTTTCATTTCTTCTT	0.398										HNSCC(17;0.042)								36	116	---	---								-	44176909	C	-	44176909	7	5	87	1	0	1	0	1	0	0	0	0	8115	826	29	0	105	0	KCTD8	4	44176909	Frame_Shift_Del	DEL	C	TCGA-FD-A3SS-01A-12D-A22Z-08	27586557	44176909	146977367	145	25813										
ATP10D	57205	broad.mit.edu	37	chr4	47583998	47583998	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctaccagggctcagatactGacatctttgcatttggaaac	8	11	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:47583998G>A	uc003gxk.1	+	21	3834	c.3670G>A	c.(3670-3672)GAC>AAC	p.D1224N	ATP10D_uc003gxl.1_Missense_Mutation_p.D472N	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1224	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CTCAGATACTGACATCTTTGC	0.448													0	0	0	0.004878	0	37	99										A	47583998	G	A	47583998	3	1	87	1	0	0	0	0	1	0	0	0	1118	1290	45	1	3748	1	ATP10D	4	47583998	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3407089	47583998	143570278	146	25814										
UGT2B4	7363	broad.mit.edu	37	chr4	70359471	70359471	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acgaactcaacatttggtaaGagtgggtgaggaaattgaaa	12	4	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:70359471G>C	uc003hek.3	-	2	857	c.810C>G	c.(808-810)CTC>CTG	p.L270L	UGT2B4_uc011cap.1_Silent_p.L134L|UGT2B4_uc003hel.3_Silent_p.L270L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	270					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CATTTGGTAAGAGTGGGTGAG	0.433													0	0	0	0.006214	0	8	146										C	70359471	G	C	70359471	2	2	87	1	0	0	0	0	0	0	0	1	16958	929	33	1		1	UGT2B4	4	70359471	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	22775473	70359471	120794805	147	25815										
ODAM	54959	broad.mit.edu	37	chr4	71063726	71063726	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccaggactctcccagttctCtttatcagctctagaccagt	6	14	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:71063726C>G	uc003hfc.2	+	4	244	c.227C>G	c.(226-228)TCT>TGT	p.S76C		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	76	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						TCCCAGTTCTCTTTATCAGCT	0.478													0	0	0	0.00623	0	40	144										G	71063726	C	G	71063726	3	3	87	1	0	0	0	0	1	0	0	0	10824	913	32	1	241	1	ODAM	4	71063726	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	704255	71063726	120090550	148	25816										
NPFFR2	10886	broad.mit.edu	37	chr4	72994488	72994488	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgatcttctttttgtgcatGatgggaaatactgtggtttg	11	5	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:72994488G>T	uc003hgg.2	+	2	584	c.486G>T	c.(484-486)ATG>ATT	p.M162I	NPFFR2_uc010iig.1_Intron|NPFFR2_uc003hgi.2_Missense_Mutation_p.M63I|NPFFR2_uc003hgh.2_Missense_Mutation_p.M60I	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	162	Helical; Name=1; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TTTTGTGCATGATGGGAAATA	0.358													1	0	3.5997e-14	0.014323	3.89058e-14	22	136										T	72994488	G	T	72994488	3	4	87	1	0	0	0	0	1	0	0	0	10578	1290	45	3	498	3	NPFFR2	4	72994488	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1930762	72994488	118159788	149	25817										
ALB	213	broad.mit.edu	37	chr4	74284010	74284010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cacactttctgagaaggagaGacaaatcaagaaacaaacgt	8	8	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:74284010G>A	uc003hgs.3	+	12	1707	c.1634G>A	c.(1633-1635)AGA>AAA	p.R545K	ALB_uc003hgw.3_Missense_Mutation_p.R353K|ALB_uc011cbe.1_Missense_Mutation_p.R224K|ALB_uc003hgt.3_Missense_Mutation_p.R545K|ALB_uc010iii.2_Missense_Mutation_p.R430K|ALB_uc003hgu.3_Missense_Mutation_p.R395K|ALB_uc003hgv.3_Missense_Mutation_p.R224K|ALB_uc011cbf.1_Missense_Mutation_p.R435K|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.R224K	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	545	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GAGAAGGAGAGACAAATCAAG	0.383													0	0	0	0.007413	0	20	39										A	74284010	G	A	74284010	3	1	87	1	0	0	0	0	1	0	0	0	486	942	33	1	1680	1	ALB	4	74284010	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1289522	74284010	116870266	150	25818										
AGPAT9	84803	broad.mit.edu	37	chr4	84457852	84457852	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cggcttcatccttttaccttCggtcttcggagtgtctctgg	10	12	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:84457852C>T	uc003how.2	+	2	295	c.77C>T	c.(76-78)TCG>TTG	p.S26L	AGPAT9_uc003hox.2_Missense_Mutation_p.S26L|AGPAT9_uc003hoy.2_Missense_Mutation_p.S26L	NM_032717	NP_116106	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	26	Helical; (Potential).				phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			skin(1)	1		Hepatocellular(203;0.114)				CTTTTACCTTCGGTCTTCGGA	0.582													0	0	0	0.001168	0	5	24										T	84457852	C	T	84457852	3	4	87	1	0	0	0	0	1	0	0	0	392	893	31	1	79	1	AGPAT9	4	84457852	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10173842	84457852	106696424	151	25819										
HSD17B13	345275	broad.mit.edu	37	chr4	88238288	88238288	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcaaatgtcttggtaatctCttcatccttggtgctgagaa	8	9	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:88238288C>T	uc003hqo.2	-	3	469	c.406G>A	c.(406-408)GAG>AAG	p.E136K	HSD17B13_uc010ikk.2_Missense_Mutation_p.E100K	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	136						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TTGGTAATCTCTTCATCCTTG	0.403													0	0	0	0.004289	0	39	57										T	88238288	C	T	88238288	3	4	87	1	0	0	0	0	1	0	0	0	7382	922	32	1	516	1	HSD17B13	4	88238288	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3780436	88238288	102915988	152	25820										
EIF4E	1977	broad.mit.edu	37	chr4	99802262	99802262	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ataaccaatcactatctttgGaggaagtcctaacctttcct	5	11	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:99802262G>C	uc003hue.2	-	7	2094	c.571C>G	c.(571-573)CCA>GCA	p.P191A	EIF4E_uc011cea.1_Missense_Mutation_p.P211A|EIF4E_uc011ceb.1_Missense_Mutation_p.P222A	NM_001968	NP_001959	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	191					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity			lung(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)		ACTATCTTTGGAGGAAGTCCT	0.363													0	0	0	0.008291	0	9	37										C	99802262	G	C	99802262	3	2	87	1	0	0	0	0	1	0	0	0	5028	1174	41	1	86	1	EIF4E	4	99802262	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11563974	99802262	91352014	153	25821										
ANK2	287	broad.mit.edu	37	chr4	114276668	114276668	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgaggtgccacagtcactgaGgactcagagacctctactga	11	12	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:114276668G>A	uc003ibe.3	+	38	6994	c.6894G>A	c.(6892-6894)GAG>GAA	p.E2298E	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.E2313E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2265					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGTCACTGAGGACTCAGAGA	0.488													0	0	0	0.008291	0	11	30										A	114276668	G	A	114276668	2	1	87	1	0	0	0	0	0	0	0	1	621	991	35	2		2	ANK2	4	114276668	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	14474406	114276668	76877608	154	25822										
NUDT6	11162	broad.mit.edu	37	chr4	123843692	123843692	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccgtaggttcgggcaagcatCgcgcgccagcggccccagct	14	16	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:123843692C>G	uc003iew.2	-	1	68	c.36G>C	c.(34-36)GCG>GCC	p.A12A	SPATA5_uc003iey.2_5'Flank|SPATA5_uc003iez.3_5'Flank|NUDT6_uc003iex.2_Intron	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	12						mitochondrion|nucleus	growth factor activity|hydrolase activity				0						GGGCAAGCATCGCGCGCCAGC	0.692													0	0	0	0.001984	0	7	20										G	123843692	C	G	123843692	2	3	87	1	0	0	0	0	0	0	0	1	10743	871	31	1		1	NUDT6	4	123843692	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9567024	123843692	67310584	155	25823										
TIGD4	201798	broad.mit.edu	37	chr4	153691640	153691640	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aacatttttaggatgataatCatttaaataataaggaagta	6	2	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691640C>A	uc003imy.2	-	2	1299	c.517G>T	c.(517-519)GAT>TAT	p.D173Y		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	173					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					GGATGATAATCATTTAAATAA	0.353													1	0	8.88839e-20	0.010818	9.72121e-20	34	72										A	153691640	C	A	153691640	3	1	87	1	0	0	0	0	1	0	0	0	15895	826	29	3	1025	3	TIGD4	4	153691640	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	29847948	153691640	37462636	156	25824			1	116		3	3	281	C		1.132703e-05
TIGD4	201798	broad.mit.edu	37	chr4	153691892	153691892	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ataccatctcattaatgcctCttccagatctgtgtaaaaag	5	10	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691892C>A	uc003imy.2	-	2	1047	c.265G>T	c.(265-267)GAG>TAG	p.E89*		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	89	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					ATTAATGCCTCTTCCAGATCT	0.363													1	0	4.37618e-36	0.01441	4.80258e-36	53	122										A	153691892	C	A	153691892	4	1	87	1	0	0	0	0	0	1	0	0	15895	922	32	3	1277	3	TIGD4	4	153691892	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	252	153691892	37462384	157	25825			1	116		3	3	281	C		1.132703e-05
TIGD4	201798	broad.mit.edu	37	chr4	153691920	153691920	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tctgtgtaaaaagcagttctCagtctttttctctttggatc	7	8	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691920C>T	uc003imy.2	-	2	1019	c.237G>A	c.(235-237)CTG>CTA	p.L79L		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	79	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					AAGCAGTTCTCAGTCTTTTTC	0.338													0	0	0	0.007835	0	44	102										T	153691920	C	T	153691920	2	4	87	1	0	0	0	0	0	0	0	1	15895	813	29	1		1	TIGD4	4	153691920	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	28	153691920	37462356	158	25826			1	116		3	3	281	C		1.132703e-05
LRAT	9227	broad.mit.edu	37	chr4	155665889	155665889	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctccagaaaaaggcactgctCaacgaggaggtggcgcggag	15	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:155665889C>G	uc003iom.1	+	1	738	c.411C>G	c.(409-411)CTC>CTG	p.L137L	uc003iol.2_Intron|LRAT_uc003ion.1_Silent_p.L137L	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	137	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	AGGCACTGCTCAACGAGGAGG	0.577													0	0	0	0.012319	0	21	32										G	155665889	C	G	155665889	2	3	87	1	0	0	0	0	0	0	0	1	8930	813	29	1		1	LRAT	4	155665889	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1973969	155665889	35488387	159	25827										
ODZ3	55714	broad.mit.edu	37	chr4	183267846	183267846	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gttaggagtttgtgaaccagCaactcgaagaggactggcat	13	7	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:183267846C>A	uc003ivd.1	+	2	312	c.275C>A	c.(274-276)GCA>GAA	p.A92E	ODZ3_uc010irv.1_Missense_Mutation_p.A92E	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	92	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGTGAACCAGCAACTCGAAGA	0.428													1	0	5.03518e-11	0.007413	5.38765e-11	17	17										A	183267846	C	A	183267846	3	1	87	1	0	0	0	0	1	0	0	0	10836	710	25	4	281	4	ODZ3	4	183267846	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	27601957	183267846	7886430	160	25828										
PDLIM3	27295	broad.mit.edu	37	chr4	186423477	186423477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggatacagagtgaccgtgtCatagccctctgggggctttg	15	9	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:186423477C>T	uc003ixw.3	-	8	1190	c.1066G>A	c.(1066-1068)GAC>AAC	p.D356N	PDLIM3_uc003ixx.3_Missense_Mutation_p.D308N|PDLIM3_uc010isi.2_RNA	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	356						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GTGACCGTGTCATAGCCCTCT	0.428													0	0	0	0.011902	0	45	86										T	186423477	C	T	186423477	3	4	87	1	0	0	0	0	1	0	0	0	11681	826	29	1	32	1	PDLIM3	4	186423477	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3155631	186423477	4730799	161	25829										
ADAMTS16	170690	broad.mit.edu	37	chr5	5237174	5237174	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagatgggactccatgctcgGaggatagccgtaatgtttgt	13	7	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:5237174G>A	uc003jdl.2	+	14	2254	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K	ADAMTS16_uc003jdk.1_Missense_Mutation_p.E706K|ADAMTS16_uc010itk.1_Intron	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	706	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCCATGCTCGGAGGATAGCCG	0.284													0	0	0	0.003954	0	23	93										A	5237174	G	A	5237174	3	1	87	1	0	0	0	0	1	0	0	0	261	1175	41	1	2170	1	ADAMTS16	5	5237174	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		5237174	175678086	162	25830										
PAPD7	11044	broad.mit.edu	37	chr5	6750570	6750570	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagcccccagctcctgtcttCaggctcctcggcctcttctg	8	19	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:6750570C>T	uc003jdx.1	+	10	1193	c.1064C>T	c.(1063-1065)TCA>TTA	p.S355L	PAPD7_uc011cmn.1_Missense_Mutation_p.S346L|PAPD7_uc010itl.1_Missense_Mutation_p.S175L	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	355	Ser-rich.				cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						CTCCTGTCTTCAGGCTCCTCG	0.572													0	0	0	0.008291	0	11	54										T	6750570	C	T	6750570	3	4	87	1	0	0	0	0	1	0	0	0	11426	838	29	1	1098	1	PAPD7	5	6750570	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1513396	6750570	174164690	163	25831										
CTNND2	1501	broad.mit.edu	37	chr5	11199639	11199639	+	Frame_Shift_Del	DEL	C	C	-													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggatgccaccacagtttttCagggcaattttgttatcatc							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:11199639delC	uc003jfa.1	-	11	2041	c.1896delG	c.(1894-1896)CTGfs	p.L632fs	CTNND2_uc010itt.2_Frame_Shift_Del_p.L541fs|CTNND2_uc011cmy.1_Frame_Shift_Del_p.L295fs|CTNND2_uc011cmz.1_Frame_Shift_Del_p.L199fs|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Frame_Shift_Del_p.L199fs	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	632	ARM 4.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CACAGTTTTTCAGGGCAATTT	0.498																		59	81	---	---								-	11199639	C	-	11199639	7	5	87	1	0	1	0	1	0	0	0	0	4020	813	29	0	1829	0	CTNND2	5	11199639	Frame_Shift_Del	DEL	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4449069	11199639	169715621	164	25832										
DNAH5	1767	broad.mit.edu	37	chr5	13919382	13919382	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggtagttaaacttggagagtCtttttttccagtgctccagc	10	8	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:13919382C>G	uc003jfd.2	-	7	920	c.878G>C	c.(877-879)AGA>ACA	p.R293T	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	293	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTGGAGAGTCTTTTTTTCCA	0.517									Kartagener_syndrome				0	0	0	0.009535	0	31	202										G	13919382	C	G	13919382	3	3	87	1	0	0	0	0	1	0	0	0	4604	913	32	1	13288	1	DNAH5	5	13919382	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2719743	13919382	166995878	165	25833										
CARD6	84674	broad.mit.edu	37	chr5	40852632	40852632	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagtcatgtcaaacatgtatCagtgccagtttgctcttccc	7	11	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:40852632C>T	uc003jmg.2	+	3	1273	c.1198C>T	c.(1198-1200)CAG>TAG	p.Q400*		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	400					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AAACATGTATCAGTGCCAGTT	0.453													0	0	0	0.014323	0	23	47										T	40852632	C	T	40852632	4	4	87	1	0	0	0	0	0	1	0	0	2650	827	29	1	1208	1	CARD6	5	40852632	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	26933250	40852632	140062628	166	25834										
IL31RA	133396	broad.mit.edu	37	chr5	55178994	55178994	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgatttaaaatacacacttCgattcaggacagtcaacagt	6	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:55178994C>T	uc003jql.2	+	5	642	c.577C>T	c.(577-579)CGA>TGA	p.R193*	IL31RA_uc003jqk.2_Nonsense_Mutation_p.R193*|IL31RA_uc011cqj.1_Nonsense_Mutation_p.R51*|IL31RA_uc003jqm.2_Nonsense_Mutation_p.R161*|IL31RA_uc003jqn.2_Nonsense_Mutation_p.R193*|IL31RA_uc010iwa.1_Nonsense_Mutation_p.R161*|IL31RA_uc003jqo.2_Nonsense_Mutation_p.R51*	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	161	Extracellular (Potential).|Fibronectin type-III 2.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATACACACTTCGATTCAGGAC	0.383													0	0	0	0.001855	0	14	31										T	55178994	C	T	55178994	4	4	87	1	0	0	0	0	0	1	0	0	7691	876	31	1	595	1	IL31RA	5	55178994	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	14326362	55178994	125736266	167	25835										
MAST4	375449	broad.mit.edu	37	chr5	66386048	66386048	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtgcctcagcccatttttcAtttgcacggaggtaaggact	10	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:66386048A>G	uc003jut.1	+	5	323	c.255A>G	c.(253-255)TCA>TCG	p.S85S	MAST4_uc003jus.2_Silent_p.S85S|MAST4_uc003juu.1_Silent_p.S92S|MAST4_uc011cra.1_Silent_p.S65S|MAST4_uc010ixa.2_RNA|MAST4_uc003juv.2_Silent_p.S80S|MAST4_uc003juw.2_Silent_p.S80S	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	274						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCCATTTTTCATTTGCACGGA	0.328													0	0	0	0.010729	0	9	7										G	66386048	A	G	66386048	2	3	87	1	0	0	0	0	0	0	0	1	9327	204	8	5		5	MAST4	5	66386048	Silent	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	11207054	66386048	114529212	168	25836										
TNPO1	3842	broad.mit.edu	37	chr5	72192888	72192888	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgggatgatctctaggtataGagatgcagccttatattcct	10	7	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:72192888G>C	uc003kck.3	+	20	2395	c.2248G>C	c.(2248-2250)GAG>CAG	p.E750Q	TNPO1_uc011csj.1_Missense_Mutation_p.E700Q|TNPO1_uc003kch.2_Missense_Mutation_p.E742Q|TNPO1_uc003kci.3_Missense_Mutation_p.E742Q|TNPO1_uc003kcg.3_Missense_Mutation_p.E742Q	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	750					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		TCTAGGTATAGAGATGCAGCC	0.343													0	0	0	0.00499	0	16	31										C	72192888	G	C	72192888	3	2	87	1	0	0	0	0	1	0	0	0	16332	943	33	1	2326	1	TNPO1	5	72192888	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5806840	72192888	108722372	169	25837										
CAST	831	broad.mit.edu	37	chr5	96086315	96086315	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctaaggccgctgctccagctCctgtgtcggaggctgtgtgt	14	12	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:96086315C>T	uc003klz.1	+	18	1366	c.1204C>T	c.(1204-1206)CCT>TCT	p.P402S	CAST_uc003klt.2_Missense_Mutation_p.P389S|CAST_uc003klu.2_Missense_Mutation_p.P485S|CAST_uc003klv.2_Missense_Mutation_p.P463S|CAST_uc003klw.2_Missense_Mutation_p.P466S|CAST_uc003klx.2_Missense_Mutation_p.P444S|CAST_uc003kly.2_Missense_Mutation_p.P450S|CAST_uc011cuo.1_Missense_Mutation_p.P448S|CAST_uc011cuq.1_Missense_Mutation_p.P250S|CAST_uc011cur.1_Missense_Mutation_p.P388S|CAST_uc011cus.1_Missense_Mutation_p.P389S|CAST_uc003kma.1_Missense_Mutation_p.P361S|CAST_uc011cut.1_Missense_Mutation_p.P330S|CAST_uc003kmb.2_Missense_Mutation_p.P348S|CAST_uc003kmc.2_Missense_Mutation_p.P402S|CAST_uc003kmd.2_Missense_Mutation_p.P380S|CAST_uc003kme.2_Missense_Mutation_p.P361S|CAST_uc003kmf.2_Missense_Mutation_p.P367S|CAST_uc003kmh.2_Missense_Mutation_p.P117S|CAST_uc010jbj.2_Missense_Mutation_p.P117S|CAST_uc010jbk.2_Missense_Mutation_p.P117S|CAST_uc010jbl.1_Missense_Mutation_p.P125S|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.P125S	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	402							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		TGCTCCAGCTCCTGTGTCGGA	0.488													0	0	0	0.008291	0	10	29										T	96086315	C	T	96086315	3	4	87	1	0	0	0	0	1	0	0	0	2684	855	30	1	1655	1	CAST	5	96086315	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	23893427	96086315	84828945	170	25838										
APC	324	broad.mit.edu	37	chr5	112103071	112103071	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaagtactggatatttagaaGaacttgagaaagagaggtaa	11	2	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:112103071G>T	uc010jby.2	+	4	786	c.406G>T	c.(406-408)GAA>TAA	p.E136*	APC_uc011cvt.1_Nonsense_Mutation_p.E146*|APC_uc003kpz.3_Nonsense_Mutation_p.E136*|APC_uc003kpy.3_Nonsense_Mutation_p.E136*|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	136	Leu-rich.|Potential.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATATTTAGAAGAACTTGAGAA	0.338		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			1	0	2.75727e-19	0.004878	3.01049e-19	35	16										T	112103071	G	T	112103071	4	4	87	1	0	0	0	0	0	1	0	0	763	943	33	3	416	3	APC	5	112103071	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	16016756	112103071	68812189	171	25839										
TSSK1B	83942	broad.mit.edu	37	chr5	112770257	112770257	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcgaggaggtcgccctggaCcgcgagctccatgacgatgt	14	13	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:112770257C>T	uc003kqm.2	-	1	472	c.280G>A	c.(280-282)GTC>ATC	p.V94I	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	94	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCGCCCTGGACCGCGAGCTCC	0.512													0	0	0	0.010729	0	11	24										T	112770257	C	T	112770257	3	4	87	1	0	0	0	0	1	0	0	0	16665	507	18	2	827	2	TSSK1B	5	112770257	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	667186	112770257	68145003	172	25840										
CEP120	153241	broad.mit.edu	37	chr5	122717855	122717855	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcccttttcttccattcctCtgcaagagcctgcatatgag	7	13	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:122717855C>T	uc003ktk.2	-	15	2135	c.2053G>A	c.(2053-2055)GAG>AAG	p.E685K	CEP120_uc011cwq.1_Missense_Mutation_p.E494K|CEP120_uc010jcz.1_Missense_Mutation_p.E659K	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	685	Potential.					centrosome				ovary(1)	1						TTCCATTCCTCTGCAAGAGCC	0.353													0	0	0	0.001168	0	5	65										T	122717855	C	T	122717855	3	4	87	1	0	0	0	0	1	0	0	0	3246	922	32	1	935	1	CEP120	5	122717855	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9947598	122717855	58197405	173	25841										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139917811	139917811	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccccctctaacatttttcatCagcctatggcaagtggtttt	6	12	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:139917811C>T	uc003lfs.1	+	32	7493	c.7369C>T	c.(7369-7371)CAG>TAG	p.Q2457*	ANKHD1_uc003lfr.2_Nonsense_Mutation_p.Q2457*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.Q1213*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.Q1112*|ANKHD1_uc010jfl.2_Nonsense_Mutation_p.Q833*|ANKHD1-EIF4EBP3_uc003lfx.1_Nonsense_Mutation_p.Q611*	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2457						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTTTTCATCAGCCTATGGC	0.408													0	0	0	0.009718	0	39	120										T	139917811	C	T	139917811	4	4	87	1	0	0	0	0	0	1	0	0	629	827	29	1	7495	1	ANKHD1-EIF4EBP3	5	139917811	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	17199956	139917811	40997449	174	25842										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139918544	139918544	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggaggcaccataataccctCtcatcctcagcttgctgatg	8	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:139918544C>G	uc003lfs.1	+	33	7569	c.7445C>G	c.(7444-7446)TCT>TGT	p.S2482C	ANKHD1_uc003lfr.2_Missense_Mutation_p.S2482C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S1238C|ANKHD1_uc003lfw.2_Missense_Mutation_p.S1137C|ANKHD1_uc010jfl.2_Missense_Mutation_p.S858C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.S627C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2482						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATACCCTCTCATCCTCAG	0.348													0	0	0	0.004007	0	14	29										G	139918544	C	G	139918544	3	3	87	1	0	0	0	0	1	0	0	0	629	913	32	1	7575	1	ANKHD1-EIF4EBP3	5	139918544	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	733	139918544	40996716	175	25843										
PCDHA1	56147	broad.mit.edu	37	chr5	140166145	140166145	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgtttgtgaattctcggatCgatcgcgaggagctgtgcca	13	8	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140166145C>T	uc003lhb.2	+	1	270	c.270C>T	c.(268-270)ATC>ATT	p.I90I	PCDHA1_uc003lha.2_Silent_p.I90I|PCDHA1_uc003lgz.2_Silent_p.I90I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	90	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGATCGCGAGG	0.577													0	0	0	0.001168	0	6	104										T	140166145	C	T	140166145	2	4	87	1	0	0	0	0	0	0	0	1	11519	874	31	1		1	PCDHA1	5	140166145	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	247601	140166145	40749115	176	25844										
PCDHA8	56140	broad.mit.edu	37	chr5	140222414	140222414	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcggcgggtgggcgagcgctCgctgtcgagctacatttcgg	18	11	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140222414C>T	uc003lhs.2	+	1	1508	c.1508C>T	c.(1507-1509)TCG>TTG	p.S503L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.S503L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGCTCGCTGTCGAGC	0.667													0	0	0	0.009718	0	39	30										T	140222414	C	T	140222414	3	4	87	1	0	0	0	0	1	0	0	0	11530	893	31	1	1510	1	PCDHA8	5	140222414	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	56269	140222414	40692846	177	25845										
ADRB2	154	broad.mit.edu	37	chr5	148207582	148207582	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catcaaggtactgtgcctagCgataacattgattcacaagg	9	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:148207582C>A	uc003lpr.1	+	1	1427	c.1188C>A	c.(1186-1188)AGC>AGA	p.S396R	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	396	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	CTGTGCCTAGCGATAACATTG	0.453													1	0	6.44725e-10	0.014323	6.83026e-10	22	21										A	148207582	C	A	148207582	3	1	87	1	0	0	0	0	1	0	0	0	341	767	27	4	1190	4	ADRB2	5	148207582	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	7985168	148207582	32707678	178	25846										
GABRP	2568	broad.mit.edu	37	chr5	170239053	170239053	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agatcagctttgccagcattGaaatttccagcgacaacgtt	8	10	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:170239053G>A	uc003mau.2	+	10	1312	c.1114G>A	c.(1114-1116)GAA>AAA	p.E372K	GABRP_uc011dev.1_3'UTR	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	372	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCCAGCATTGAAATTTCCAG	0.413													0	0	0	0.008871	0	20	72										A	170239053	G	A	170239053	3	1	87	1	0	0	0	0	1	0	0	0	6174	1291	45	1	1148	1	GABRP	5	170239053	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	22031471	170239053	10676207	179	25847										
UIMC1	51720	broad.mit.edu	37	chr5	176409576	176409576	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccttcttctccaggttccgaGattcggagacttctttaact	7	12	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:176409576G>A	uc011dfp.1	-	2	208	c.41C>T	c.(40-42)TCT>TTT	p.S14F	UIMC1_uc003mfc.1_5'UTR|UIMC1_uc003mfd.1_5'UTR|UIMC1_uc003mfg.1_Missense_Mutation_p.S14F|UIMC1_uc003mfh.1_Missense_Mutation_p.S14F|UIMC1_uc010jkj.1_Missense_Mutation_p.S14F|UIMC1_uc011dfq.1_Missense_Mutation_p.S14F	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	14	Necessary for transcriptional repression.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGTTCCGAGATTCGGAGAC	0.373													0	0	0	0.008291	0	11	67										A	176409576	G	A	176409576	3	1	87	1	0	0	0	0	1	0	0	0	16968	942	33	1	2174	1	UIMC1	5	176409576	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6170523	176409576	4505684	180	25848										
BTNL8	79908	broad.mit.edu	37	chr5	180326337	180326337	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcatgctcagtttggttctGagtctcctcaagctgggatc	10	11	5	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:180326337G>C	uc003mmp.2	+	1	261	c.27G>C	c.(25-27)CTG>CTC	p.L9L	BTNL8_uc003mmq.2_Silent_p.L9L|BTNL8_uc011dhg.1_5'UTR|BTNL8_uc010jll.2_Silent_p.L9L|BTNL8_uc010jlm.2_Silent_p.L9L	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	9						integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTTGGTTCTGAGTCTCCTCA	0.453													0	0	0	0.00874	0	40	180										C	180326337	G	C	180326337	2	2	87	1	0	0	0	0	0	0	0	1	1567	1277	45	1		1	BTNL8	5	180326337	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3916761	180326337	588923	181	25849										
TFAP2A	7020	broad.mit.edu	37	chr6	10404933	10404933	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccttgttaatagggatggcgGagacggcattgctgttggac	15	7	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:10404933G>A	uc003myr.2	-	4	824	c.572C>T	c.(571-573)TCC>TTC	p.S191F	TFAP2A_uc003myq.2_Missense_Mutation_p.S185F|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.S191F|TFAP2A_uc003myt.2_Missense_Mutation_p.S187F|TFAP2A_uc003myu.1_Missense_Mutation_p.S191F	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	191					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGGATGGCGGAGACGGCATT	0.627													0	0	0	0.003271	0	34	43										A	10404933	G	A	10404933	3	1	87	1	0	0	0	0	1	0	0	0	15784	1174	41	1	757	1	TFAP2A	6	10404933	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		10404933	160710134	182	25850										
JARID2	3720	broad.mit.edu	37	chr6	15468887	15468887	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aacagccaccaacaatgcttCatcttcatgccagtcgaccc	5	16	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:15468887C>T	uc003nbj.2	+	5	852	c.608C>T	c.(607-609)TCA>TTA	p.S203L	JARID2_uc011diu.1_Missense_Mutation_p.S67L|JARID2_uc011div.1_Missense_Mutation_p.S31L|JARID2_uc011diw.1_Missense_Mutation_p.S165L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	203					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AACAATGCTTCATCTTCATGC	0.468													0	0	0	0.00499	0	16	51										T	15468887	C	T	15468887	3	4	87	1	0	0	0	0	1	0	0	0	7945	838	29	1	626	1	JARID2	6	15468887	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5063954	15468887	155646180	183	25851										
MYLIP	29116	broad.mit.edu	37	chr6	16144013	16144022	+	Frame_Shift_Del	DEL	TCGTGCTCTT	TCGTGCTCTT	-													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caaggaatctgggaacagcaTcgtgctcttgtttaaaatga							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:16144013_16144022delTCGTGCTCTT	uc003nbq.2	+	5	983_992	c.746_755delTCGTGCTCTT	c.(745-756)ATCGTGCTCTTGfs	p.I249fs	MYLIP_uc003nbr.2_Frame_Shift_Del_p.I68fs	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	249_252	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GGGAACAGCATCGTGCTCTTGTTTAAAATG	0.519																		40	116	---	---								-	16144022	TCGTGCTCTT	-	16144013	7	5	87	1	0	1	0	1	0	0	0	0	10055	1435	50	0	764	0	MYLIP	6	16144013	Frame_Shift_Del	DEL	TCGTGCTCTT	TCGA-FD-A3SS-01A-12D-A22Z-08	675126	16144013	154971054	184	25852										
ALDH5A1	7915	broad.mit.edu	37	chr6	24528378	24528378	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgaagagactttcgggcctCtggcaccagttatcaagtaa	10	9	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:24528378C>T	uc003neg.2	+	8	1355	c.1327C>T	c.(1327-1329)CTG>TTG	p.L443L	ALDH5A1_uc003nef.2_Silent_p.L456L	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	443					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TTTCGGGCCTCTGGCACCAGT	0.488													0	0	0	0.014323	0	22	29										T	24528378	C	T	24528378	2	4	87	1	0	0	0	0	0	0	0	1	502	912	32	1		1	ALDH5A1	6	24528378	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	8384365	24528378	146586689	185	25853										
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184092	26184092	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggccgtgaccaaggcgcaGaagaaggacggcaagaagcg	16	9	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:26184092G>A	uc003ngt.2	+	1	69	c.69G>A	c.(67-69)CAG>CAA	p.Q23Q		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	23					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CCAAGGCGCAGAAGAAGGACG	0.577													0	0	0	0.01441	0	59	114										A	26184092	G	A	26184092	2	1	87	1	0	0	0	0	0	0	0	1	7144	933	33	1		1	HIST1H2BE	6	26184092	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1655714	26184092	144930975	186	25854										
ZNF193	7746	broad.mit.edu	37	chr6	28200360	28200360	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgaagtaaccaagactgagGacagagagttggtgctaagg	14	5	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:28200360G>A	uc003nkq.1	+	4	704	c.589G>A	c.(589-591)GAC>AAC	p.D197N	ZNF193_uc003nkr.1_Missense_Mutation_p.D197N|ZNF193_uc010jqz.1_Missense_Mutation_p.D248N	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	197					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CAAGACTGAGGACAGAGAGTT	0.423													0	0	0	0.001984	0	6	77										A	28200360	G	A	28200360	3	1	87	1	0	0	0	0	1	0	0	0	17754	1174	41	1	599	1	ZNF193	6	28200360	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2016268	28200360	142914707	187	25855										
TRIM27	5987	broad.mit.edu	37	chr6	28872256	28872256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggtccacttggctttatctCccacctctacctcccaataa	4	16	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:28872256C>T	uc003nlr.2	-	8	1492	c.1133G>A	c.(1132-1134)GGA>GAA	p.G378E	TRIM27_uc003nls.2_Intron|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	378	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						GGCTTTATCTCCCACCTCTAC	0.532			T	RET	papillary thyroid								0	0	0	0.003163	0	16	75										T	28872256	C	T	28872256	3	4	87	1	0	0	0	0	1	0	0	0	16498	855	30	1	412	1	TRIM27	6	28872256	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	671896	28872256	142242811	188	25856										
ZBTB22	9278	broad.mit.edu	37	chr6	33284067	33284067	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcagtggactccctggggctGaagtagttgctgctgctggg	16	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:33284067G>A	uc003oeb.2	-	2	779	c.627C>T	c.(625-627)TTC>TTT	p.F209F	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.F209F	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCCTGGGGCTGAAGTAGTTGC	0.617													0	0	0	0.010504	0	22	35										A	33284067	G	A	33284067	2	1	87	1	0	0	0	0	0	0	0	1	17527	1281	45	1		1	ZBTB22	6	33284067	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4411811	33284067	137831000	189	25857										
RNF8	9025	broad.mit.edu	37	chr6	37336788	37336788	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggtgaccatgtccaggattCtgaggctcaaaatacagatg	11	8	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:37336788C>T	uc003onq.3	+	3	962	c.769C>T	c.(769-771)CTG>TTG	p.L257L	RNF8_uc003onr.3_Silent_p.L257L|RNF8_uc011dtx.1_Silent_p.L189L	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	257					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						GTCCAGGATTCTGAGGCTCAA	0.433													0	0	0	0.010504	0	20	90										T	37336788	C	T	37336788	2	4	87	1	0	0	0	0	0	0	0	1	13500	912	32	1		1	RNF8	6	37336788	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4052721	37336788	133778279	190	25858										
TRERF1	55809	broad.mit.edu	37	chr6	42196160	42196160	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggtgtccacaacttcagcctCttccatgacacctcccaact	5	17	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:42196160C>T	uc003osd.2	-	18	4089	c.3526G>A	c.(3526-3528)GAG>AAG	p.E1176K	TRERF1_uc011duq.1_Missense_Mutation_p.E1093K|TRERF1_uc003osb.2_Missense_Mutation_p.E944K|TRERF1_uc003osc.2_Missense_Mutation_p.E932K|TRERF1_uc003ose.2_Missense_Mutation_p.E1196K	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1176	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACTTCAGCCTCTTCCATGACA	0.532													0	0	0	0.010729	0	12	148										T	42196160	C	T	42196160	3	4	87	1	0	0	0	0	1	0	0	0	16472	922	32	1	80	1	TRERF1	6	42196160	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4859372	42196160	128918907	191	25859										
XPO5	57510	broad.mit.edu	37	chr6	43521164	43521164	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acactttccaaaaaaagagtCatggcttcccactgcacgaa	6	12	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43521164C>T	uc003ovp.2	-	14	1729	c.1518G>A	c.(1516-1518)ATG>ATA	p.M506I		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	506					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			AAAAAAGAGTCATGGCTTCCC	0.368													0	0	0	0.004672	0	3	12										T	43521164	C	T	43521164	3	4	87	1	0	0	0	0	1	0	0	0	17444	826	29	1	2172	1	XPO5	6	43521164	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1325004	43521164	127593903	192	25860										
XPO5	57510	broad.mit.edu	37	chr6	43528732	43528732	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtttgatggtgtttctacatCagaatctgcaccctgtagga	10	8	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43528732C>G	uc003ovp.2	-	10	1235	c.1024G>C	c.(1024-1026)GAT>CAT	p.D342H		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	342					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GTTTCTACATCAGAATCTGCA	0.368													0	0	0	0.00245	0	14	67										G	43528732	C	G	43528732	3	3	87	1	0	0	0	0	1	0	0	0	17444	826	29	1	2682	1	XPO5	6	43528732	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	7568	43528732	127586335	193	25861										
POLH	5429	broad.mit.edu	37	chr6	43555015	43555015	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttatacttcttaggtaccgGgaagccagtgttgaagtgat	11	7	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43555015G>A	uc003ovq.3	+	4	583	c.279G>A	c.(277-279)CGG>CGA	p.R93R	POLH_uc010jyu.2_Intron|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_5'UTR	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	93	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TTAGGTACCGGGAAGCCAGTG	0.448								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				0	0	0	0.001855	0	12	158										A	43555015	G	A	43555015	2	1	87	1	0	0	0	0	0	0	0	1	12202	1219	43	2		2	POLH	6	43555015	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	26283	43555015	127560052	194	25862										
POLH	5429	broad.mit.edu	37	chr6	43555211	43555211	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggccctacaacggcagaaGagactgttcagaaaggtact	11	9	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43555211G>C	uc003ovq.3	+	4	779	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	POLH_uc010jyu.2_Intron|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.E60Q	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	159	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AACGGCAGAAGAGACTGTTCA	0.473								DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				0	0	0	0.000602	0	5	61										C	43555211	G	C	43555211	3	2	87	1	0	0	0	0	1	0	0	0	12202	943	33	1	485	1	POLH	6	43555211	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	196	43555211	127559856	195	25863										
SLC25A27	9481	broad.mit.edu	37	chr6	46644175	46644175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaaaatcagagagatgagtgGagtcagtccattttaaaccc	9	7	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:46644175G>A	uc003oyh.2	+	9	1207	c.956G>A	c.(955-957)GGA>GAA	p.G319E	SLC25A27_uc011dwb.1_Intron|SLC25A27_uc003oyg.2_Intron|SLC25A27_uc011dwc.1_Missense_Mutation_p.G233E|SLC25A27_uc003oyi.2_Missense_Mutation_p.G249E	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	319					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			GAGATGAGTGGAGTCAGTCCA	0.368													0	0	0	0.00278	0	20	87										A	46644175	G	A	46644175	3	1	87	1	0	0	0	0	1	0	0	0	14490	1174	41	1	990	1	SLC25A27	6	46644175	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3088964	46644175	124470892	196	25864										
CD2AP	23607	broad.mit.edu	37	chr6	47563717	47563717	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atcttctggaacagtgtaccCaaagcgacctgaaaaaccag	8	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:47563717C>G	uc003oyw.2	+	12	1685	c.1229C>G	c.(1228-1230)CCA>CGA	p.P410R		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	410	SH3-binding (Potential).|Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACAGTGTACCCAAAGCGACCT	0.423													0	0	0	0.009535	0	29	176										G	47563717	C	G	47563717	3	3	87	1	0	0	0	0	1	0	0	0	2994	594	21	4	1275	4	CD2AP	6	47563717	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	919542	47563717	123551350	197	25865										
PHF3	23469	broad.mit.edu	37	chr6	64395311	64395311	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaagattcagagttgcaattCtggggttaaatctgtgaaaa	10	4	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:64395311C>A	uc003pep.1	+	3	1714	c.1688C>A	c.(1687-1689)TCT>TAT	p.S563Y	PHF3_uc010kaf.1_Missense_Mutation_p.S563Y|PHF3_uc003pem.2_Missense_Mutation_p.S516Y|PHF3_uc010kag.1_Missense_Mutation_p.S475Y|PHF3_uc010kah.1_Missense_Mutation_p.S377Y|PHF3_uc003pen.2_Missense_Mutation_p.S475Y|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.S563Y	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	563					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGTTGCAATTCTGGGGTTAAA	0.343													1	0	8.24728e-16	0.004656	8.95898e-16	26	39										A	64395311	C	A	64395311	3	1	87	1	0	0	0	0	1	0	0	0	11836	913	32	3	1698	3	PHF3	6	64395311	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	16831594	64395311	106719756	198	25866										
FAM46A	55603	broad.mit.edu	37	chr6	82459924	82459924	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gatcttgttacaaaggtgatCaaaggcttcctggaaatcgc	10	8	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:82459924C>G	uc003pjg.2	-	3	1135	c.817G>C	c.(817-819)GAT>CAT	p.D273H	FAM46A_uc003pjf.2_Missense_Mutation_p.D292H	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	273											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		CAAAGGTGATCAAAGGCTTCC	0.493													0	0	0	0.003163	0	15	68										G	82459924	C	G	82459924	3	3	87	1	0	0	0	0	1	0	0	0	5565	826	29	1	515	1	FAM46A	6	82459924	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	18064613	82459924	88655143	199	25867										
MDN1	23195	broad.mit.edu	37	chr6	90420473	90420473	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaatgtgagtaaaaattcctGagagatgcagcactggcttc	11	7	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:90420473G>C	uc003pnn.1	-	50	7808	c.7692C>G	c.(7690-7692)CTC>CTG	p.L2564L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2564					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAAAATTCCTGAGAGATGCAG	0.348													0	0	0	0.003163	0	15	33										C	90420473	G	C	90420473	2	2	87	1	0	0	0	0	0	0	0	1	9415	1277	45	1		1	MDN1	6	90420473	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7960549	90420473	80694594	200	25868										
CASP8AP2	9994	broad.mit.edu	37	chr6	90577477	90577477	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgaggaagaggatgcatctGagcaagatattcatttagct	11	5	2	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:90577477G>C	uc003pnr.2	+	8	4664	c.4468G>C	c.(4468-4470)GAG>CAG	p.E1490Q	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1490Q|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1490Q	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1490					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GGATGCATCTGAGCAAGATAT	0.408													0	0	0	0.004289	0	34	52										C	90577477	G	C	90577477	3	2	87	1	0	0	0	0	1	0	0	0	2678	1291	45	1	4494	1	CASP8AP2	6	90577477	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	157004	90577477	80537590	201	25869										
BVES	11149	broad.mit.edu	37	chr6	105577271	105577271	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	taccggtctcttcttgtataAaagatacgacagatgcaaaa	7	8	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:105577271A>G	uc003pqw.2	-	3	491	c.334T>C	c.(334-336)TTA>CTA	p.L112L	BVES_uc003pqx.2_Silent_p.L112L|BVES_uc003pqy.2_Silent_p.L112L	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	112	Helical; (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TTCTTGTATAAAAGATACGAC	0.348													0	0	0	0.008871	0	21	45										G	105577271	A	G	105577271	2	3	87	1	0	0	0	0	0	0	0	1	1575	11	1	5		5	BVES	6	105577271	Silent	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	14999794	105577271	65537796	202	25870										
GJA1	2697	broad.mit.edu	37	chr6	121768780	121768780	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgccaaagactgtgggtctCaaaaatatgcttatttcaat	7	8	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:121768780C>A	uc003pyr.2	+	2	1037	c.787C>A	c.(787-789)CAA>AAA	p.Q263K	GJA1_uc011ebo.1_Missense_Mutation_p.Q164K|GJA1_uc011ebp.1_Missense_Mutation_p.Q51K	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	263	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CTGTGGGTCTCAAAAATATGC	0.517													1	0	4.96729e-08	0.008871	5.19381e-08	21	87										A	121768780	C	A	121768780	3	1	87	1	0	0	0	0	1	0	0	0	6400	827	29	3	789	3	GJA1	6	121768780	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	16191509	121768780	49346287	203	25871										
PTPRK	5796	broad.mit.edu	37	chr6	128411102	128411102	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatccgtcttgcctgtatttCagcaatctttaatgtctttg	6	9	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:128411102C>T	uc003qbk.2	-	8	1565	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	PTPRK_uc003qbj.2_Missense_Mutation_p.E400K|PTPRK_uc010kfc.2_Missense_Mutation_p.E400K|PTPRK_uc011ebu.1_Missense_Mutation_p.E400K|PTPRK_uc003qbl.1_Missense_Mutation_p.E270K|PTPRK_uc011ebv.1_Missense_Mutation_p.E400K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	400	Extracellular (Potential).|Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCCTGTATTTCAGCAATCTTT	0.383													0	0	0	0.00623	0	37	94										T	128411102	C	T	128411102	3	4	87	1	0	0	0	0	1	0	0	0	12805	835	29	1	3238	1	PTPRK	6	128411102	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6642322	128411102	42703965	204	25872										
L3MBTL3	84456	broad.mit.edu	37	chr6	130392177	130392177	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttgaggcagtagacaaaaaGaatccctcattcatctgtgt	8	9	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:130392177G>C	uc003qbt.2	+	13	1319	c.1149G>C	c.(1147-1149)AAG>AAC	p.K383N	L3MBTL3_uc003qbu.2_Missense_Mutation_p.K358N	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	383	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TAGACAAAAAGAATCCCTCAT	0.423													0	0	0	0.01441	0	59	289										C	130392177	G	C	130392177	3	2	87	1	0	0	0	0	1	0	0	0	8593	933	33	1	1191	1	L3MBTL3	6	130392177	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1981075	130392177	40722890	205	25873										
BCLAF1	9774	broad.mit.edu	37	chr6	136582453	136582453	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttcattattttccatggtctCttcttcatcttcaacaatcc	2	12	6	0	rs141900019		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136582453C>T	uc003qgx.1	-	12	2960	c.2707G>A	c.(2707-2709)GAG>AAG	p.E903K	BCLAF1_uc011edb.1_Missense_Mutation_p.E182K|BCLAF1_uc003qgw.1_Missense_Mutation_p.E730K|BCLAF1_uc003qgy.1_Missense_Mutation_p.E852K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.E901K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	903					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCCATGGTCTCTTCTTCATCT	0.373													0	0	0	0.004007	0	15	291										T	136582453	C	T	136582453	3	4	87	1	0	0	0	0	1	0	0	0	1383	922	32	1	63	1	BCLAF1	6	136582453	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6190276	136582453	34532614	206	25874										
BCLAF1	9774	broad.mit.edu	37	chr6	136589379	136589379	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagttttaaattcttcttctCtttccttcttactctccttt	2	11	5	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136589379C>T	uc003qgx.1	-	10	2571	c.2318G>A	c.(2317-2319)AGA>AAA	p.R773K	BCLAF1_uc011edb.1_Missense_Mutation_p.R101K|BCLAF1_uc003qgw.1_Missense_Mutation_p.R600K|BCLAF1_uc003qgy.1_Missense_Mutation_p.R771K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R771K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	773					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTCTTCTTCTCTTTCCTTCTT	0.383													0	0	0	0.007413	0	19	203										T	136589379	C	T	136589379	3	4	87	1	0	0	0	0	1	0	0	0	1383	913	32	1	460	1	BCLAF1	6	136589379	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6926	136589379	34525688	207	25875										
KIAA1244	57221	broad.mit.edu	37	chr6	138619775	138619775	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggaaagacatgtgtctcaGaaggctgtttccttcatcca	9	9	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:138619775G>A	uc003qhu.2	+	22	3681	c.3681G>A	c.(3679-3681)CAG>CAA	p.Q1227Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1227					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATGTGTCTCAGAAGGCTGTTT	0.473													0	0	0	0.007291	0	28	25										A	138619775	G	A	138619775	2	1	87	1	0	0	0	0	0	0	0	1	8217	933	33	1		1	KIAA1244	6	138619775	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2030396	138619775	32495292	208	25876										
SHPRH	257218	broad.mit.edu	37	chr6	146242491	146242491	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caccagtccttcttcatcttCtatcatctcctcaaatattg	2	14	7	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:146242491C>T	uc003qlf.2	-	21	4219	c.3820G>A	c.(3820-3822)GAA>AAA	p.E1274K	SHPRH_uc003qld.2_Missense_Mutation_p.E1278K|SHPRH_uc003qle.2_Missense_Mutation_p.E1278K|SHPRH_uc003qlg.1_Missense_Mutation_p.E830K|SHPRH_uc003qlh.2_Missense_Mutation_p.E199K|SHPRH_uc003qli.1_Missense_Mutation_p.E199K	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1274					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TCTTCATCTTCTATCATCTCC	0.433													0	0	0	0.009096	0	4	25										T	146242491	C	T	146242491	3	4	87	1	0	0	0	0	1	0	0	0	14291	922	32	1	1288	1	SHPRH	6	146242491	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	7622716	146242491	24872576	209	25877										
TULP4	56995	broad.mit.edu	37	chr6	158735144	158735144	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtccccaagagtgagaaggaGaagcctgtgtgcaggagacg	16	8	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:158735144G>A	uc003qrf.2	+	1	1453	c.96G>A	c.(94-96)GAG>GAA	p.E32E	TULP4_uc011efo.1_Silent_p.E32E|TULP4_uc003qrg.2_Silent_p.E32E	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	32					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GTGAGAAGGAGAAGCCTGTGT	0.572													0	0	0	0.001855	0	14	27										A	158735144	G	A	158735144	2	1	87	1	0	0	0	0	0	0	0	1	16773	933	33	1		1	TULP4	6	158735144	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	12492653	158735144	12379923	210	25878										
C6orf70	55780	broad.mit.edu	37	chr6	170156863	170156863	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctttcttttaagagatctgCtttcatctgaggagcttgct	8	9	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:170156863C>T	uc003qxg.1	+	5	499	c.466C>T	c.(466-468)CTT>TTT	p.L156F	C6orf70_uc011ehb.1_Missense_Mutation_p.L30F|C6orf70_uc003qxh.1_Missense_Mutation_p.L156F|C6orf70_uc010kky.1_Missense_Mutation_p.L30F	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	156						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		AAGAGATCTGCTTTCATCTGA	0.308													0	0	0	0.003755	0	30	87										T	170156863	C	T	170156863	3	4	87	1	0	0	0	0	1	0	0	0	2370	797	28	2	484	2	C6orf70	6	170156863	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11421719	170156863	958204	211	25879										
CHST12	55501	broad.mit.edu	37	chr7	2473142	2473142	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcctgcccgcctcggcgcgcGaggccttccgcgctggcctc	14	20	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:2473142G>A	uc003smc.2	+	2	1003	c.868G>A	c.(868-870)GAG>AAG	p.E290K	CHST12_uc003smd.2_Missense_Mutation_p.E290K	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	290	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTCGGCGCGCGAGGCCTTCCG	0.652													0	0	0	0.010729	0	11	99										A	2473142	G	A	2473142	3	1	87	1	0	0	0	0	1	0	0	0	3400	1059	37	1	870	1	CHST12	7	2473142	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		2473142	156665521	212	25880										
WIPF3	644150	broad.mit.edu	37	chr7	29915522	29915522	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gttggctgatatccagcaagGaactcgcctgcgcaaagtca	11	11	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:29915522G>A	uc003taj.1	+	2	167	c.167G>A	c.(166-168)GGA>GAA	p.G56E		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	56										ovary(1)	1						ATCCAGCAAGGAACTCGCCTG	0.582													0	0	0	0.006214	0	9	58										A	29915522	G	A	29915522	3	1	87	1	0	0	0	0	1	0	0	0	17366	1174	41	1	173	1	WIPF3	7	29915522	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	27442380	29915522	129223141	213	25881										
CCDC129	223075	broad.mit.edu	37	chr7	31682680	31682680	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttccaaatatgatcatcctCtggggtttatggtaacccac	7	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:31682680C>G	uc003tcj.1	+	11	2689	c.1696C>G	c.(1696-1698)CTG>GTG	p.L566V	CCDC129_uc011kad.1_Missense_Mutation_p.L576V|CCDC129_uc003tci.1_Missense_Mutation_p.L417V|CCDC129_uc011kae.1_Missense_Mutation_p.L592V|CCDC129_uc003tck.1_Missense_Mutation_p.L474V	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	566											0						TGATCATCCTCTGGGGTTTAT	0.517													0	0	0	0.010729	0	12	223										G	31682680	C	G	31682680	3	3	87	1	0	0	0	0	1	0	0	0	2764	912	32	1	1734	1	CCDC129	7	31682680	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1767158	31682680	127455983	214	25882										
NT5C3	51251	broad.mit.edu	37	chr7	33063689	33063689	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttttccctttatatgaaaatCtactgagtgtcatatcaaag	5	7	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:33063689C>G	uc003tdk.2	-	3	361	c.284G>C	c.(283-285)AGA>ACA	p.R95T	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.R56T|NT5C3_uc003tdj.2_Missense_Mutation_p.R56T	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	95				R -> K (in Ref. 11; AA sequence).	nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			ATATGAAAATCTACTGAGTGT	0.338													0	0	0	0.001168	0	5	19										G	33063689	C	G	33063689	3	3	87	1	0	0	0	0	1	0	0	0	10688	913	32	1	754	1	NT5C3	7	33063689	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1381009	33063689	126074974	215	25883										
ABCA13	154664	broad.mit.edu	37	chr7	48313605	48313605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgttaaatataaaaaaacctCtttgttcatcaaatggctca	4	7	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:48313605C>G	uc003toq.2	+	17	4367	c.4342C>G	c.(4342-4344)CTT>GTT	p.L1448V	ABCA13_uc010kyr.2_Missense_Mutation_p.L951V	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1448					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AAAAAAACCTCTTTGTTCATC	0.264													0	0	0	0.010729	0	10	55										G	48313605	C	G	48313605	3	3	87	1	0	0	0	0	1	0	0	0	31	913	32	1	4237	1	ABCA13	7	48313605	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	15249916	48313605	110825058	216	25884										
ZNF479	90827	broad.mit.edu	37	chr7	57187752	57187752	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtctctctccagtatgaattCtcttgtggtcagtgagggtt	11	8	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57187752C>T	uc010kzo.2	-	5	1641	c.1370G>A	c.(1369-1371)AGA>AAA	p.R457K		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAATTCTCTTGTGGTC	0.433													0	0	0	0.00308	0	8	133										T	57187752	C	T	57187752	3	4	87	1	0	0	0	0	1	0	0	0	17930	913	32	1	208	1	ZNF479	7	57187752	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	8874147	57187752	101950911	217	25885										
ZNF479	90827	broad.mit.edu	37	chr7	57188486	57188487	+	Missense_Mutation	DNP	GG	GG	AA													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccacattctttgcatttgtaGgacttctccctagtatgaat							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57188486_57188487GG>AA	uc010kzo.2	-	5	906_907	c.635_636CC>TT	c.(634-636)TCC>TTT	p.S212F		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	212	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TGCATTTGTAGGACTTCTCCCT	0.332													0	0	0	0.004672	0	11	19										AA	57188487	GG	AA	57188486	3	1	87	1	0	0	0	0	1	0	0	0	17930	987	35	2	942	2	ZNF479	7	57188486	Missense_Mutation	DNP	GG	TCGA-FD-A3SS-01A-12D-A22Z-08	734	57188486	101950177	218	25886										
CACNA2D1	781	broad.mit.edu	37	chr7	82072690	82072690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgccgacttacgtgacggccGaagggaacggctcctccgac	13	15	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:82072690G>A	uc003uhr.1	-	1	342	c.86C>T	c.(85-87)TCG>TTG	p.S29L		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	29	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CGTGACGGCCGAAGGGAACGG	0.488													0	0	0	0.001984	0	7	21										A	82072690	G	A	82072690	3	1	87	1	0	0	0	0	1	0	0	0	2548	1059	37	1	3345	1	CACNA2D1	7	82072690	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	24884204	82072690	77065973	219	25887										
ABCB1	5243	broad.mit.edu	37	chr7	87165842	87165842	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtggtgtttttagggtcatCaaaccaactcacatcctgtg	9	9	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:87165842C>T	uc003uiz.1	-	21	2831	c.2413G>A	c.(2413-2415)GAT>AAT	p.D805N	ABCB1_uc011khc.1_Missense_Mutation_p.D741N	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	805	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTAGGGTCATCAAACCAACTC	0.343													0	0	0	0.004482	0	6	56										T	87165842	C	T	87165842	3	4	87	1	0	0	0	0	1	0	0	0	40	826	29	1	1465	1	ABCB1	7	87165842	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5093152	87165842	71972821	220	25888										
TMEM130	222865	broad.mit.edu	37	chr7	98446226	98446226	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctccaccatgtccttttgctGagtggcattccgcagggtca	10	13	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:98446226G>C	uc003upo.2	-	7	1288	c.1099C>G	c.(1099-1101)CAG>GAG	p.Q367E	TMEM130_uc011kiq.1_Missense_Mutation_p.Q348E|TMEM130_uc011kir.1_Missense_Mutation_p.Q367E|TMEM130_uc003upn.2_Missense_Mutation_p.Q265E	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	367	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCTTTTGCTGAGTGGCATTC	0.552													0	0	0	0.008291	0	11	96										C	98446226	G	C	98446226	3	2	87	1	0	0	0	0	1	0	0	0	16040	1299	45	1	216	1	TMEM130	7	98446226	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11280384	98446226	60692437	221	25889										
TRRAP	8295	broad.mit.edu	37	chr7	98581089	98581089	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcatcattaccagggtaaacCgacctggtccggcatgcatt	10	12	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:98581089C>T	uc003upp.2	+	59	9217	c.9008C>T	c.(9007-9009)CCG>CTG	p.P3003L	TRRAP_uc011kis.1_Intron|TRRAP_uc003upr.2_Intron	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3003	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			cagggtaaaccgacctggtcc	0.259													0	0	0	0.012319	0	22	20										T	98581089	C	T	98581089	3	4	87	1	0	0	0	0	1	0	0	0	16598	667	23	2		2	TRRAP	7	98581089	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	134863	98581089	60557574	222	25890										
CYP3A5	1577	broad.mit.edu	37	chr7	99247765	99247765	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agagcaagtttcatgttcatGagagcaaacctcatgccaat	8	9	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:99247765G>C	uc003urq.2	-	12	1431	c.1344C>G	c.(1342-1344)CTC>CTG	p.L448L	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Silent_p.L268L|CYP3A5_uc003urr.2_Silent_p.L335L|CYP3A5_uc011kiy.1_Silent_p.L438L|CYP3A5_uc003urs.2_Silent_p.L96L|CYP3A5_uc010lgg.2_Silent_p.L54L	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	448					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TCATGTTCATGAGAGCAAACC	0.398													0	0	0	0.004482	0	9	170										C	99247765	G	C	99247765	2	2	87	1	0	0	0	0	0	0	0	1	4180	1277	45	1		1	CYP3A5	7	99247765	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	666676	99247765	59890898	223	25891										
ZAN	7455	broad.mit.edu	37	chr7	100395059	100395059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tactactggccgtgaccagaGagtgcatttacagaacgagg	12	9	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100395059G>C	uc003uwj.2	+	47	8503	c.8338G>C	c.(8338-8340)GAG>CAG	p.E2780Q	ZAN_uc003uwk.2_Missense_Mutation_p.E2689Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.E729Q	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2780	VWFC 5.|Cytoplasmic (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGTGACCAGAGAGTGCATTTA	0.602													0	0	0	0.005443	0	24	39										C	100395059	G	C	100395059	3	2	87	1	0	0	0	0	1	0	0	0	17510	943	33	1	8580	1	ZAN	7	100395059	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1147294	100395059	58743604	224	25892										
VGF	7425	broad.mit.edu	37	chr7	100806828	100806828	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccgccctcctctgtcccctCggcctccttccgccggtggc	9	23	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100806828C>T	uc003uxx.3	-	2	1515	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	433	Asp/Glu-rich (acidic).				response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					tctgtcccctcggcctccttc	0.493													0	0	0	0.004672	0	3	15										T	100806828	C	T	100806828	3	4	87	1	0	0	0	0	1	0	0	0	17154	893	31	1	554	1	VGF	7	100806828	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	411769	100806828	58331835	225	25893										
LRWD1	222229	broad.mit.edu	37	chr7	102106340	102106340	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgacgcagctgcaggagcttGacctgtctaacaaccacctg	10	13	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:102106340G>A	uc003uzn.2	+	2	295	c.157G>A	c.(157-159)GAC>AAC	p.D53N	ALKBH4_uc003uzl.2_5'Flank|ALKBH4_uc003uzm.2_5'Flank|LRWD1_uc003uzo.2_5'UTR	NM_152892	NP_690852	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain	53	LRR 2.				chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			skin(1)	1						GCAGGAGCTTGACCTGTCTAA	0.622													0	0	0	0.00333	0	24	42										A	102106340	G	A	102106340	3	1	87	1	0	0	0	0	1	0	0	0	9047	1290	45	1	163	1	LRWD1	7	102106340	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1299512	102106340	57032323	226	25894										
RELN	5649	broad.mit.edu	37	chr7	103207108	103207108	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttcgcgtcctgtggcaggtCaatggaaatgatctgtggtt	13	8	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:103207108C>T	uc003vca.2	-	32	4847	c.4687G>A	c.(4687-4689)GAC>AAC	p.D1563N	RELN_uc010liz.2_Missense_Mutation_p.D1563N	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1563					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTGGCAGGTCAATGGAAATG	0.478													0	0	0	0.010818	0	33	73										T	103207108	C	T	103207108	3	4	87	1	0	0	0	0	1	0	0	0	13220	826	29	1	5831	1	RELN	7	103207108	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1100768	103207108	55931555	227	25895										
COG5	10466	broad.mit.edu	37	chr7	106924162	106924162	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tagggttgtagtgagtctttCaaagccttttctggactgtg	12	6	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:106924162C>G	uc003ved.2	-	13	1947	c.1422G>C	c.(1420-1422)TTG>TTC	p.L474F	COG5_uc003vec.2_Missense_Mutation_p.L474F|COG5_uc003vee.2_Missense_Mutation_p.L474F	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	474					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						GTGAGTCTTTCAAAGCCTTTT	0.368													0	0	0	0.012319	0	20	104										G	106924162	C	G	106924162	3	3	87	1	0	0	0	0	1	0	0	0	3661	825	29	1	1204	1	COG5	7	106924162	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3717054	106924162	52214501	228	25896										
PPP1R3A	5506	broad.mit.edu	37	chr7	113518227	113518227	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgaacttctggaaacttcttCaggtttagactcaggataag	9	7	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:113518227C>T	uc010ljy.1	-	4	2951	c.2920G>A	c.(2920-2922)GAA>AAA	p.E974K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	974					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GAAACTTCTTCAGGTTTAGAC	0.378													0	0	0	0.009718	0	45	76										T	113518227	C	T	113518227	3	4	87	1	0	0	0	0	1	0	0	0	12371	835	29	1	452	1	PPP1R3A	7	113518227	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6594065	113518227	45620436	229	25897										
TFEC	22797	broad.mit.edu	37	chr7	115624399	115624399	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaggccagcatcactgtccaGagttgtgtgtgcatgctgca	13	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:115624399G>C	uc003vhj.1	-	2	281	c.97C>G	c.(97-99)CTG>GTG	p.L33V	TFEC_uc003vhk.1_Missense_Mutation_p.L33V|TFEC_uc003vhl.3_Missense_Mutation_p.L33V|TFEC_uc011kmw.1_Missense_Mutation_p.L123V	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	33	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			TCACTGTCCAGAGTTGTGTGT	0.468													0	0	0	0.009535	0	32	148										C	115624399	G	C	115624399	3	2	87	1	0	0	0	0	1	0	0	0	15799	933	33	1	974	1	TFEC	7	115624399	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2106172	115624399	43514264	230	25898										
MET	4233	broad.mit.edu	37	chr7	116380132	116380132	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tacacactggttatcactggGaagaaggtaagctgttccca	10	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:116380132G>A	uc003vij.2	+	4	1708	c.1521G>A	c.(1519-1521)GGG>GGA	p.G507G	MET_uc010lkh.2_Silent_p.G507G|MET_uc011knc.1_Silent_p.G507G|MET_uc011knd.1_Silent_p.G507G|MET_uc011kne.1_Silent_p.G507G|MET_uc011knf.1_Silent_p.G507G|MET_uc011kng.1_Silent_p.G507G|MET_uc011knh.1_Silent_p.G507G|MET_uc011kni.1_Silent_p.G507G|MET_uc011knj.1_Silent_p.G77G|MET_uc011kna.1_Silent_p.G507G|MET_uc011knb.1_Silent_p.G507G	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	507	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTATCACTGGGAAGAAGGTAA	0.438			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.001984	0	7	135										A	116380132	G	A	116380132	2	1	87	1	0	0	0	0	0	0	0	1	9485	1161	41	1		1	MET	7	116380132	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	755733	116380132	42758531	231	25899										
GRM8	2918	broad.mit.edu	37	chr7	126542614	126542614	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acctgtgcatttctttatatGactgttccttttcccatgtg	6	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:126542614G>A	uc003vlr.2	-	5	1449	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.H380Y|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.H101Y	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	380	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTCTTTATATGACTGTTCCTT	0.353										HNSCC(24;0.065)			0	0	0	0.00308	0	6	64										A	126542614	G	A	126542614	3	1	87	1	0	0	0	0	1	0	0	0	6803	1290	45	1	1662	1	GRM8	7	126542614	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10162482	126542614	32596049	232	25900										
TNPO3	23534	broad.mit.edu	37	chr7	128610354	128610354	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatcagttctttccgtaattCaaagtcttcttcatgctgta	5	9	6	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:128610354C>T	uc003vol.1	-	20	2820	c.2446G>A	c.(2446-2448)GAA>AAA	p.E816K	TNPO3_uc010llx.1_Missense_Mutation_p.E227K|TNPO3_uc003vom.1_Missense_Mutation_p.E750K|TNPO3_uc010lly.1_Missense_Mutation_p.E850K|TNPO3_uc010llz.1_Missense_Mutation_p.E752K	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	816					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TTCCGTAATTCAAAGTCTTCT	0.458													0	0	0	0.013726	0	34	183										T	128610354	C	T	128610354	3	4	87	1	0	0	0	0	1	0	0	0	16334	835	29	1	337	1	TNPO3	7	128610354	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2067740	128610354	30528309	233	25901										
CLEC5A	23601	broad.mit.edu	37	chr7	141645174	141645174	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctggtggtggtgaaaccatCgttacttttgttaaaaatct	9	7	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:141645174C>T	uc003vwv.1	-	3	303	c.106G>A	c.(106-108)GAT>AAT	p.D36N	CLEC5A_uc011krm.1_Missense_Mutation_p.D36N|CLEC5A_uc003vww.1_Missense_Mutation_p.D36N|CLEC5A_uc010lnq.1_Missense_Mutation_p.D36N|CLEC5A_uc010lnr.1_RNA	NM_013252	NP_037384	Q9NY25	CLC5A_HUMAN	C-type lectin, superfamily member 5	36	Extracellular (Potential).				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity				0	Melanoma(164;0.0171)					GTGAAACCATCGTTACTTTTG	0.438													0	0	0	0.003954	0	27	54										T	141645174	C	T	141645174	3	4	87	1	0	0	0	0	1	0	0	0	3519	884	31	1	480	1	CLEC5A	7	141645174	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	13034820	141645174	17493489	234	25902										
TRPV6	55503	broad.mit.edu	37	chr7	142569636	142569636	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctgaagggacagcccagctCtagtttttccactgagtctt	10	11	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:142569636C>T	uc003wbx.1	-	15	2218	c.2002G>A	c.(2002-2004)GAG>AAG	p.E668K	TRPV6_uc003wbw.1_Missense_Mutation_p.E454K|TRPV6_uc010lou.1_Missense_Mutation_p.E539K	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	668	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CAGCCCAGCTCTAGTTTTTCC	0.582													0	0	0	0.00499	0	17	57										T	142569636	C	T	142569636	3	4	87	1	0	0	0	0	1	0	0	0	16597	922	32	1	179	1	TRPV6	7	142569636	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	924462	142569636	16569027	235	25903										
CNTNAP2	26047	broad.mit.edu	37	chr7	147869504	147869504	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaaatggaggcaaatgcctaGagagataccacggttactcc	10	9	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:147869504G>C	uc003weu.1	+	18	3460	c.2944G>C	c.(2944-2946)GAG>CAG	p.E982Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	982	EGF-like 2.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAAATGCCTAGAGAGATACCA	0.473										HNSCC(39;0.1)			0	0	0	0.00333	0	26	119										C	147869504	G	C	147869504	3	2	87	1	0	0	0	0	1	0	0	0	3647	943	33	1	3014	1	CNTNAP2	7	147869504	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5299868	147869504	11269159	236	25904										
ZNF777	27153	broad.mit.edu	37	chr7	149129350	149129350	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgatgtgcaggcggaagctCttcttgcactcggggcacgt	14	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:149129350C>T	uc003wfv.2	-	6	2176	c.2013G>A	c.(2011-2013)AAG>AAA	p.K671K		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	671	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGCGGAAGCTCTTCTTGCACT	0.622													0	0	0	0.007291	0	30	133										T	149129350	C	T	149129350	2	4	87	1	0	0	0	0	0	0	0	1	18147	912	32	1		1	ZNF777	7	149129350	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1259846	149129350	10009313	237	25905										
CRYGN	155051	broad.mit.edu	37	chr7	151135092	151135092	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcccactcaccattcctacaGgccgacaggagcccatgtgg	10	16	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:151135092G>T	uc003wke.2	-	2	356	c.260C>A	c.(259-261)CCT>CAT	p.P87H	CRYGN_uc003wkf.2_Missense_Mutation_p.P87H|CRYGN_uc003wkg.2_RNA|CRYGN_uc010lqd.1_5'Flank	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	87	Beta/gamma crystallin 'Greek key' 2.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATTCCTACAGGCCGACAGGA	0.642													1	0	3.45872e-05	0.004007	3.5642e-05	16	52										T	151135092	G	T	151135092	3	4	87	1	0	0	0	0	1	0	0	0	3918	1000	35	4	300	4	CRYGN	7	151135092	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2005742	151135092	8003571	238	25906										
MLL3	58508	broad.mit.edu	37	chr7	151860518	151860518	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gttgtcatcaaattctacccGaggtggtggtccactctgtg	11	10	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:151860518G>A	uc003wla.2	-	43	10363	c.10144C>T	c.(10144-10146)CGG>TGG	p.R3382W	MLL3_uc003wkz.2_Missense_Mutation_p.R2443W|MLL3_uc003wky.2_Missense_Mutation_p.R891W	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3382	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AATTCTACCCGAGGTGGTGGT	0.458			N		medulloblastoma								0	0	0	0.01441	0	63	108										A	151860518	G	A	151860518	3	1	87	1	0	0	0	0	1	0	0	0	9622	1057	37	1	4659	1	MLL3	7	151860518	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	725426	151860518	7278145	239	25907										
PTPRN2	5799	broad.mit.edu	37	chr7	158282442	158282442	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcaccgttcacacaggcctCggacgctccgcagaggccct	10	18	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:158282442C>T	uc003wno.2	-	2	269	c.148G>A	c.(148-150)GAG>AAG	p.E50K	PTPRN2_uc003wnp.2_Intron|PTPRN2_uc003wnq.2_Missense_Mutation_p.E50K|PTPRN2_uc003wnr.2_Missense_Mutation_p.E50K|PTPRN2_uc011kwa.1_Missense_Mutation_p.E73K	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	50	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACACAGGCCTCGGACGCTCCG	0.731													0	0	0	0.009096	0	4	5										T	158282442	C	T	158282442	3	4	87	1	0	0	0	0	1	0	0	0	12808	893	31	1	2987	1	PTPRN2	7	158282442	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6421924	158282442	856221	240	25908										
CSMD1	64478	broad.mit.edu	37	chr8	2832056	2832056	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctatgaggctctcgctccctCtgcaggagtagtgcacgacg	12	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:2832056C>G	uc011kwk.1	-	56	9050	c.8660G>C	c.(8659-8661)AGA>ACA	p.R2887T	CSMD1_uc011kwj.1_Missense_Mutation_p.R2216T|CSMD1_uc010lrg.2_Missense_Mutation_p.R897T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2887	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCGCTCCCTCTGCAGGAGTA	0.597													0	0	0	0.010729	0	12	16										G	2832056	C	G	2832056	3	3	87	1	0	0	0	0	1	0	0	0	3944	913	32	1	2097	1	CSMD1	8	2832056	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		2832056	143531966	241	25909										
NEIL2	252969	broad.mit.edu	37	chr8	11637344	11637344	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agagagacgcccctgcaggaGatgctgggaggtggctgcgt	18	9	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:11637344G>C	uc003wug.2	+	3	1051	c.376G>C	c.(376-378)GAT>CAT	p.D126H	NEIL2_uc003wue.2_Missense_Mutation_p.D126H|NEIL2_uc003wuf.2_Missense_Mutation_p.D65H|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	126					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		CCCTGCAGGAGATGCTGGGAG	0.577								BER_DNA_glycosylases					0	0	0	0.003163	0	16	83										C	11637344	G	C	11637344	3	2	87	1	0	0	0	0	1	0	0	0	10319	942	33	1	387	1	NEIL2	8	11637344	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	8805288	11637344	134726678	242	25910										
PCM1	5108	broad.mit.edu	37	chr8	17813070	17813070	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcaatggagaatccaatagCctcacatcatctgttcctta	6	11	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:17813070C>T	uc003wyi.3	+	10	1802	c.1380C>T	c.(1378-1380)AGC>AGT	p.S460S	PCM1_uc011kyh.1_Silent_p.S460S|PCM1_uc003wyj.3_Silent_p.S460S|PCM1_uc003wyh.2_Silent_p.S499S|PCM1_uc010lta.1_Silent_p.S499S	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	460					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		AATCCAATAGCCTCACATCAT	0.458			T	RET|JAK2	papillary thyroid|CML|MPD								0	0	0	0.00308	0	7	23										T	17813070	C	T	17813070	2	4	87	1	0	0	0	0	0	0	0	1	11584	738	26	2		2	PCM1	8	17813070	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6175726	17813070	128550952	243	25911										
ADAM18	8749	broad.mit.edu	37	chr8	39537620	39537620	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgctaataaaagtgacgctCaatctacagtttattcatat	5	7	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:39537620C>T	uc003xni.2	+	16	1696	c.1696C>T	c.(1696-1698)CAA>TAA	p.Q566*	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Nonsense_Mutation_p.Q542*	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	566	Cys-rich.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AAGTGACGCTCAATCTACAGT	0.383													0	0	0	0.001984	0	7	91										T	39537620	C	T	39537620	4	4	87	1	0	0	0	0	0	1	0	0	239	827	29	1	1758	1	ADAM18	8	39537620	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	21724550	39537620	106826402	244	25912										
MYST3	7994	broad.mit.edu	37	chr8	41906305	41906305	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggaattgagtcctttatttGagacttttaaaattgttcca	7	5	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:41906305G>C	uc010lxb.2	-	3	735	c.191C>G	c.(190-192)TCA>TGA	p.S64*	MYST3_uc010lxc.2_Nonsense_Mutation_p.S64*|MYST3_uc003xon.3_Nonsense_Mutation_p.S64*|MYST3_uc010lxd.2_Nonsense_Mutation_p.S64*	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	64	Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TCCTTTATTTGAGACTTTTAA	0.368													0	0	0	0.005443	0	28	206										C	41906305	G	C	41906305	4	2	87	1	0	0	0	0	0	1	0	0	10104	1294	45	1	5887	1	MYST3	8	41906305	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2368685	41906305	104457717	245	25913										
DKK4	27121	broad.mit.edu	37	chr8	42232338	42232338	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgggttggttttcctggactGggtgcccagttgttccttct	13	9	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:42232338G>A	uc003xpb.2	-	3	467	c.356C>T	c.(355-357)CCA>CTA	p.P119L		NM_014420	NP_055235	Q9UBT3	DKK4_HUMAN	dickkopf homolog 4 precursor	119					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				ovary(1)	1	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			TTCCTGGACTGGGTGCCCAGT	0.443													0	0	0	0.01441	0	71	222										A	42232338	G	A	42232338	3	1	87	1	0	0	0	0	1	0	0	0	4547	1348	47	2	326	2	DKK4	8	42232338	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	326033	42232338	104131684	246	25914										
ARFGEF1	10565	broad.mit.edu	37	chr8	68211501	68211501	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggccctgaaagcagccacaTattgtttcaataattctatc	7	10	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:68211501T>C	uc003xxo.1	-	4	792	c.402A>G	c.(400-402)ATA>ATG	p.I134M		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	134					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AGCAGCCACATATTGTTTCAA	0.328													0	0	0	0.00308	0	8	15										C	68211501	T	C	68211501	3	2	87	1	0	0	0	0	1	0	0	0	852	1396	49	5	5291	5	ARFGEF1	8	68211501	Missense_Mutation	SNP	T	TCGA-FD-A3SS-01A-12D-A22Z-08	25979163	68211501	78152521	247	25915										
ZFHX4	79776	broad.mit.edu	37	chr8	77766229	77766229	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	actccatggatgccactgatCaagtggtatacaagcattgc	9	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:77766229C>T	uc003yav.2	+	10	7324	c.6937C>T	c.(6937-6939)CAA>TAA	p.Q2313*	ZFHX4_uc003yau.1_Nonsense_Mutation_p.Q2358*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.Q2313*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2313						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCCACTGATCAAGTGGTATA	0.493										HNSCC(33;0.089)			0	0	0	0.009535	0	29	136										T	77766229	C	T	77766229	4	4	87	1	0	0	0	0	0	1	0	0	17632	827	29	1	7106	1	ZFHX4	8	77766229	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9554728	77766229	68597793	248	25916										
DCAF4L2	138009	broad.mit.edu	37	chr8	88885613	88885613	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgtactgaaagagtgatacGcgtggatgctcagggaccag	14	8	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:88885613G>A	uc003ydz.2	-	1	684	c.587C>T	c.(586-588)GCG>GTG	p.A196V		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	196										ovary(1)	1						AGAGTGATACGCGTGGATGCT	0.557													0	0	0	0.007835	0	42	77										A	88885613	G	A	88885613	3	1	87	1	0	0	0	0	1	0	0	0	4272	1087	38	2	604	2	DCAF4L2	8	88885613	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11119384	88885613	57478409	249	25917										
KIAA1429	25962	broad.mit.edu	37	chr8	95556077	95556077	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atatgctctattgtctggcaGactgctatgggctcttactc	9	10	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:95556077G>A	uc003ygo.1	-	2	170	c.157C>T	c.(157-159)CTG>TTG	p.L53L	KIAA1429_uc003ygp.2_Silent_p.L53L	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	53					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTGTCTGGCAGACTGCTATGG	0.358													0	0	0	0.00874	0	38	166										A	95556077	G	A	95556077	2	1	87	1	0	0	0	0	0	0	0	1	8231	933	33	1		1	KIAA1429	8	95556077	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6670464	95556077	50807945	250	25918										
VPS13B	157680	broad.mit.edu	37	chr8	100866426	100866426	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggacccatcttcaccactgcGaggcagcttgtgcacgccct	10	16	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:100866426G>A	uc003yiv.2	+	56	10995	c.10884G>A	c.(10882-10884)GCG>GCA	p.A3628A	VPS13B_uc003yiw.2_Silent_p.A3603A	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3628					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCACCACTGCGAGGCAGCTTG	0.562													0	0	0	0.000602	0	4	47										A	100866426	G	A	100866426	2	1	87	1	0	0	0	0	0	0	0	1	17187	1045	37	1		1	VPS13B	8	100866426	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5310349	100866426	45497596	251	25919										
OC90	729330	broad.mit.edu	37	chr8	133053363	133053363	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcttggagacagtccatctCagcggcctcctcatagcacc	9	15	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:133053363C>G	uc003ytg.2	-	4	337	c.337G>C	c.(337-339)GAG>CAG	p.E113Q	OC90_uc011lix.1_Missense_Mutation_p.E129Q	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	129	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CAGTCCATCTCAGCGGCCTCC	0.587													0	0	0	0.007291	0	21	81										G	133053363	C	G	133053363	3	3	87	1	0	0	0	0	1	0	0	0	10814	835	29	1	1084	1	OC90	8	133053363	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	32186937	133053363	13310659	252	25920										
COL22A1	169044	broad.mit.edu	37	chr8	139701194	139701194	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccccatctttccctggggtgCctctgaggccgggagcaccc	12	17	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:139701194C>A	uc003yvd.2	-	37	3275	c.2828G>T	c.(2827-2829)GGC>GTC	p.G943V	COL22A1_uc011ljo.1_Missense_Mutation_p.G243V	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	943	Pro-rich.|Gly-rich.|Collagen-like 8.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCTGGGGTGCCTCTGAGGCC	0.512										HNSCC(7;0.00092)			1	0	1.15088e-07	0.004007	1.19945e-07	12	66										A	139701194	C	A	139701194	3	1	87	1	0	0	0	0	1	0	0	0	3681	739	26	4	2168	4	COL22A1	8	139701194	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6647831	139701194	6662828	253	25921										
TSNARE1	203062	broad.mit.edu	37	chr8	143396398	143396398	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catagcactgaatggcatctGagagctgggttttcagccgg	13	9	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:143396398G>A	uc003ywk.2	-	8	1158	c.1040C>T	c.(1039-1041)TCA>TTA	p.S347L	TSNARE1_uc011lju.1_Missense_Mutation_p.S346L|TSNARE1_uc003ywj.2_Missense_Mutation_p.S347L|TSNARE1_uc003ywl.3_Missense_Mutation_p.S127L	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	347					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AATGGCATCTGAGAGCTGGGT	0.647													0	0	0	0.013537	0	11	72										A	143396398	G	A	143396398	3	1	87	1	0	0	0	0	1	0	0	0	16627	1294	45	1	525	1	TSNARE1	8	143396398	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3695204	143396398	2967624	254	25922										
GLI4	2738	broad.mit.edu	37	chr8	144358969	144358969	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	accagcgggtgcactaccgcGagtagccgggcgggggctcg	18	13	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:144358969G>C	uc003yxx.2	+	4	1211	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	376						nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCACTACCGCGAGTAGCCGGG	0.736													0	0	0	0.004672	0	3	7										C	144358969	G	C	144358969	3	2	87	1	0	0	0	0	1	0	0	0	6440	1059	37	1	1136	1	GLI4	8	144358969	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	962571	144358969	2005053	255	25923										
SCRIB	23513	broad.mit.edu	37	chr8	144889748	144889748	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcctcaatgcgagcaggctCtatcagcaggttattggcct	10	12	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:144889748C>G	uc003yzp.1	-	16	2159	c.2152G>C	c.(2152-2154)GAG>CAG	p.E718Q	SCRIB_uc003yzo.1_Missense_Mutation_p.E718Q	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	718	Interaction with ARHGEF7.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGAGCAGGCTCTATCAGCAGG	0.617													0	0	0	0.004482	0	7	84										G	144889748	C	G	144889748	3	3	87	1	0	0	0	0	1	0	0	0	13937	922	32	1	2903	1	SCRIB	8	144889748	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	530779	144889748	1474274	256	25924										
KIAA2026	158358	broad.mit.edu	37	chr9	5969048	5969048	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggacacaaccccagtttttCagcacagttatcaggatttt	7	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:5969048C>T	uc003zjq.3	-	3	1399	c.1183G>A	c.(1183-1185)GAA>AAA	p.E395K		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	395										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCCAGTTTTTCAGCACAGTTA	0.418													0	0	0	0.000602	0	5	19										T	5969048	C	T	5969048	3	4	87	1	0	0	0	0	1	0	0	0	8270	835	29	1	5152	1	KIAA2026	9	5969048	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		5969048	135244383	257	25925										
PTPRD	5789	broad.mit.edu	37	chr9	8484129	8484129	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atcaacttactttatattctCatttgcaggtacttcaggca	5	9	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:8484129C>T	uc003zkk.2	-	29	4114	c.3403G>A	c.(3403-3405)GAG>AAG	p.E1135K	PTPRD_uc003zkp.2_Missense_Mutation_p.E724K|PTPRD_uc003zkq.2_Missense_Mutation_p.E724K|PTPRD_uc003zkr.2_Missense_Mutation_p.E719K|PTPRD_uc003zks.2_Missense_Mutation_p.E714K|PTPRD_uc003zkl.2_Missense_Mutation_p.E1126K|PTPRD_uc003zkm.2_Missense_Mutation_p.E1122K|PTPRD_uc003zkn.2_Missense_Mutation_p.E724K|PTPRD_uc003zko.2_Missense_Mutation_p.E721K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1135	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTTATATTCTCATTTGCAGGT	0.383										TSP Lung(15;0.13)			0	0	0	0.00308	0	6	102										T	8484129	C	T	8484129	3	4	87	1	0	0	0	0	1	0	0	0	12799	835	29	1	2468	1	PTPRD	9	8484129	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2515081	8484129	132729302	258	25926										
PTPRD	5789	broad.mit.edu	37	chr9	8518022	8518022	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gacatgttgagtgggatccaTtgtataataaactctatatc	8	6	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:8518022T>C	uc003zkk.2	-	20	2080	c.1369A>G	c.(1369-1371)ATG>GTG	p.M457V	PTPRD_uc003zkp.2_Missense_Mutation_p.M457V|PTPRD_uc003zkq.2_Missense_Mutation_p.M457V|PTPRD_uc003zkr.2_Missense_Mutation_p.M451V|PTPRD_uc003zks.2_Missense_Mutation_p.M447V|PTPRD_uc003zkl.2_Missense_Mutation_p.M457V|PTPRD_uc003zkm.2_Missense_Mutation_p.M444V|PTPRD_uc003zkn.2_Missense_Mutation_p.M457V|PTPRD_uc003zko.2_Missense_Mutation_p.M454V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	457	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTGGGATCCATTGTATAATAA	0.423										TSP Lung(15;0.13)			0	0	0	0.01441	0	61	125										C	8518022	T	C	8518022	3	2	87	1	0	0	0	0	1	0	0	0	12799	1493	52	5	4541	5	PTPRD	9	8518022	Missense_Mutation	SNP	T	TCGA-FD-A3SS-01A-12D-A22Z-08	33893	8518022	132695409	259	25927										
PSIP1	11168	broad.mit.edu	37	chr9	15486887	15486887	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aacactagtttccttttcttCaacttcaacatcagatgatg	4	10	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:15486887C>T	uc003zlv.3	-	5	661	c.331G>A	c.(331-333)GAA>AAA	p.E111K	PSIP1_uc003zlw.3_Missense_Mutation_p.E111K|PSIP1_uc003zlz.3_Missense_Mutation_p.E111K|PSIP1_uc003zma.3_Missense_Mutation_p.E111K|PSIP1_uc003zly.2_Missense_Mutation_p.E111K	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	111					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TCCTTTTCTTCAACTTCAACA	0.318													0	0	0	0.004878	0	37	59										T	15486887	C	T	15486887	3	4	87	1	0	0	0	0	1	0	0	0	12663	835	29	1	1338	1	PSIP1	9	15486887	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6968865	15486887	125726544	260	25928										
C9orf93	203238	broad.mit.edu	37	chr9	15920318	15920318	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagcttgcaagcactagaatCatgacattagagaaggaaat	9	7	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:15920318C>G	uc003zmd.2	+	25	3966	c.3651C>G	c.(3649-3651)ATC>ATG	p.I1217M	C9orf93_uc003zme.2_Missense_Mutation_p.I1132M|C9orf93_uc011lmu.1_Missense_Mutation_p.I1225M	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1217	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		GCACTAGAATCATGACATTAG	0.338													0	0	0	0.00308	0	8	49										G	15920318	C	G	15920318	3	3	87	1	0	0	0	0	1	0	0	0	2506	816	29	1	3745	1	C9orf93	9	15920318	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	433431	15920318	125293113	261	25929										
DENND4C	55667	broad.mit.edu	37	chr9	19324380	19324380	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gatttttaaaaagtcgagatCgtgcctatgcaaaattctat	7	6	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:19324380C>T	uc003znq.2	+	9	1153	c.1120C>T	c.(1120-1122)CGT>TGT	p.R374C	DENND4C_uc011lnc.1_Intron	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	374	dDENN.					integral to membrane				ovary(1)|skin(1)	2						AAGTCGAGATCGTGCCTATGC	0.279													0	0	0	0.009535	0	29	71										T	19324380	C	T	19324380	3	4	87	1	0	0	0	0	1	0	0	0	4435	884	31	1	1154	1	DENND4C	9	19324380	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3404062	19324380	121889051	262	25930										
SLC24A2	25769	broad.mit.edu	37	chr9	19619665	19619665	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtggagggaggcagagcttCcacctcgctggagacgcggc	17	11	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:19619665C>T	uc003zoa.1	-	3	1057	c.995G>A	c.(994-996)GGA>GAA	p.G332E	SLC24A2_uc003zob.1_Missense_Mutation_p.G332E	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	332	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCAGAGCTTCCACCTCGCTG	0.488													0	0	0	0.00308	0	8	103										T	19619665	C	T	19619665	3	4	87	1	0	0	0	0	1	0	0	0	14466	855	30	1	1022	1	SLC24A2	9	19619665	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	295285	19619665	121593766	263	25931										
SHB	6461	broad.mit.edu	37	chr9	37948664	37948664	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagtagtcatgcttgctggtCtggctgttccggacaaggta	14	8	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:37948664C>T	uc004aax.2	-	5	1882	c.1314G>A	c.(1312-1314)CAG>CAA	p.Q438Q		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	438	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCTTGCTGGTCTGGCTGTTCC	0.647													0	0	0	0.001984	0	7	68										T	37948664	C	T	37948664	2	4	87	1	0	0	0	0	0	0	0	1	14268	912	32	1		1	SHB	9	37948664	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	18328999	37948664	103264767	264	25932										
HNRNPK	3190	broad.mit.edu	37	chr9	86586835	86586835	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggtggaggaagaggaagattCcgagctctgctaccaccccg	14	11	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86586835C>A	uc004ang.3	-	11	1139	c.915G>T	c.(913-915)CGG>CGT	p.R305R	HNRNPK_uc011lsw.1_Silent_p.R65R|HNRNPK_uc004and.3_Silent_p.R65R|HNRNPK_uc004ank.3_Silent_p.R305R|HNRNPK_uc004anf.3_Silent_p.R305R|HNRNPK_uc004anh.3_Silent_p.R281R|HNRNPK_uc011lsx.1_Silent_p.R281R|HNRNPK_uc004ani.3_Silent_p.R305R|HNRNPK_uc004anj.3_Silent_p.R305R|HNRNPK_uc004ann.3_Silent_p.R281R|HNRNPK_uc004anl.3_Silent_p.R305R|HNRNPK_uc004anm.3_Silent_p.R305R|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	305	5 X 4 AA repeats of G-X-G-G.|2 X 6 AA approximate repeats.|2 X 22 AA approximate repeats.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GAGGAAGATTCCGAGCTCTGC	0.517													1	0	3.27435e-08	0.00245	3.43486e-08	13	100										A	86586835	C	A	86586835	2	1	87	1	0	0	0	0	0	0	0	1	7269	842	30	3		3	HNRNPK	9	86586835	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	48638171	86586835	54626596	265	25933										
HNRNPK	3190	broad.mit.edu	37	chr9	86586966	86586966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccgaccaggaggcattctgtCaaaaccacctcttccccgca	7	17	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86586966C>G	uc004ang.3	-	11	1008	c.784G>C	c.(784-786)GAC>CAC	p.D262H	HNRNPK_uc011lsw.1_Missense_Mutation_p.D22H|HNRNPK_uc004and.3_Missense_Mutation_p.D22H|HNRNPK_uc004ank.3_Missense_Mutation_p.D262H|HNRNPK_uc004anf.3_Missense_Mutation_p.D262H|HNRNPK_uc004anh.3_Missense_Mutation_p.D238H|HNRNPK_uc011lsx.1_Missense_Mutation_p.D238H|HNRNPK_uc004ani.3_Missense_Mutation_p.D262H|HNRNPK_uc004anj.3_Missense_Mutation_p.D262H|HNRNPK_uc004ann.3_Missense_Mutation_p.D238H|HNRNPK_uc004anl.3_Missense_Mutation_p.D262H|HNRNPK_uc004anm.3_Missense_Mutation_p.D262H|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	262	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.|RNA-binding RGG-box.|2 X 6 AA approximate repeats.|Necessary for interaction with DDX1.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGCATTCTGTCAAAACCACCT	0.532													0	0	0	0.003163	0	14	68										G	86586966	C	G	86586966	3	3	87	1	0	0	0	0	1	0	0	0	7269	826	29	1	673	1	HNRNPK	9	86586966	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	131	86586966	54626465	266	25934										
PTCH1	5727	broad.mit.edu	37	chr9	98209579	98209579	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tagaaatttcaaaagcgtctCtgcgcggtctgtaggggggt	14	7	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:98209579C>T	uc004avk.3	-	23	4147	c.3959G>A	c.(3958-3960)AGA>AAA	p.R1320K	PTCH1_uc010mrn.2_Missense_Mutation_p.R112K|PTCH1_uc010mro.2_Missense_Mutation_p.R1169K|PTCH1_uc010mrp.2_Missense_Mutation_p.R1169K|PTCH1_uc010mrq.2_Missense_Mutation_p.R1169K|PTCH1_uc004avl.3_Missense_Mutation_p.R1169K|PTCH1_uc010mrr.2_Missense_Mutation_p.R1254K|PTCH1_uc004avm.3_Missense_Mutation_p.R1319K	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1320	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAAAGCGTCTCTGCGCGGTCT	0.667									Basal_Cell_Nevus_syndrome				0	0	0	0.006122	0	17	77										T	98209579	C	T	98209579	3	4	87	1	0	0	0	0	1	0	0	0	12730	913	32	1	388	1	PTCH1	9	98209579	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11622613	98209579	43003852	267	25935										
PTCH1	5727	broad.mit.edu	37	chr9	98241349	98241349	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctcgttccagttgatgtgtGagacatactcgtaccccttg	9	12	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:98241349G>A	uc004avk.3	-	8	1336	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	PTCH1_uc010mro.2_Missense_Mutation_p.S232L|PTCH1_uc010mrp.2_Missense_Mutation_p.S232L|PTCH1_uc010mrq.2_Missense_Mutation_p.S232L|PTCH1_uc004avl.3_Missense_Mutation_p.S232L|PTCH1_uc010mrr.2_Missense_Mutation_p.S317L|PTCH1_uc004avm.3_Missense_Mutation_p.S382L|PTCH1_uc010mrs.1_Missense_Mutation_p.S103L	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	383	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GTTGATGTGTGAGACATACTC	0.552									Basal_Cell_Nevus_syndrome				0	0	0	0.003954	0	26	34										A	98241349	G	A	98241349	3	1	87	1	0	0	0	0	1	0	0	0	12730	1294	45	1	3259	1	PTCH1	9	98241349	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	31770	98241349	42972082	268	25936										
STX17	55014	broad.mit.edu	37	chr9	102729973	102729973	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gacagcattgcagaccatgtCaacagtgctgctgtgaatgt	11	9	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:102729973C>T	uc004bal.3	+	7	757	c.621C>T	c.(619-621)GTC>GTT	p.V207V	STX17_uc010msx.2_RNA|STX17_uc011lvd.1_RNA	NM_017919	NP_060389	P56962	STX17_HUMAN	syntaxin 17	207	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CAGACCATGTCAACAGTGCTG	0.493													0	0	0	0.006999	0	35	46										T	102729973	C	T	102729973	2	4	87	1	0	0	0	0	0	0	0	1	15339	813	29	1		1	STX17	9	102729973	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4488624	102729973	38483458	269	25937										
OR13F1	138805	broad.mit.edu	37	chr9	107266864	107266864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgtacctctcccttgccatGggctccactgagtgtgtgct	10	13	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:107266864G>A	uc011lvm.1	+	1	321	c.321G>A	c.(319-321)ATG>ATA	p.M107I		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						CCCTTGCCATGGGCTCCACTG	0.522													0	0	0	0.00333	0	25	41										A	107266864	G	A	107266864	3	1	87	1	0	0	0	0	1	0	0	0	10941	1348	47	2	323	2	OR13F1	9	107266864	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4536891	107266864	33946567	270	25938										
CTNNAL1	8727	broad.mit.edu	37	chr9	111746665	111746665	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catcattgtacacttttcaaGaactgccctagctgctgcca	6	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:111746665G>A	uc004bdo.1	-	5	733	c.691C>T	c.(691-693)CTT>TTT	p.L231F	CTNNAL1_uc010mts.1_5'Flank|CTNNAL1_uc010mtt.1_Missense_Mutation_p.L231F|CTNNAL1_uc004bdp.1_Missense_Mutation_p.L231F	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	231					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		CACTTTTCAAGAACTGCCCTA	0.348													0	0	0	0.003755	0	32	106										A	111746665	G	A	111746665	3	1	87	1	0	0	0	0	1	0	0	0	4015	942	33	1	1573	1	CTNNAL1	9	111746665	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4479801	111746665	29466766	271	25939										
EPB41L4B	54566	broad.mit.edu	37	chr9	112042115	112042115	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	accgcaacctgggcagagtcGaggaactggaggccaaagta	14	10	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:112042115G>A	uc004bdz.1	-	2	688	c.393C>T	c.(391-393)CTC>CTT	p.L131L	EPB41L4B_uc004bea.2_Silent_p.L131L	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	131	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						GGGCAGAGTCGAGGAACTGGA	0.443													0	0	0	0.010729	0	8	43										A	112042115	G	A	112042115	2	1	87	1	0	0	0	0	0	0	0	1	5156	1045	37	1		1	EPB41L4B	9	112042115	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	295450	112042115	29171316	272	25940										
CEP110	11064	broad.mit.edu	37	chr9	123900853	123900853	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagcccttcaagcagaacttGagaaggaaaggcaagccctc	10	12	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:123900853G>C	uc004bkx.1	+	14	2264	c.2233G>C	c.(2233-2235)GAG>CAG	p.E745Q	CEP110_uc004bky.1_Missense_Mutation_p.E349Q|CEP110_uc004bkz.1_Missense_Mutation_p.E193Q|CEP110_uc004bla.1_Missense_Mutation_p.E193Q	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	745	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AGCAGAACTTGAGAAGGAAAG	0.398													0	0	0	0.00245	0	13	51										C	123900853	G	C	123900853	3	2	87	1	0	0	0	0	1	0	0	0	3245	1291	45	1	2287	1	CEP110	9	123900853	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11858738	123900853	17312578	273	25941										
DENND1A	57706	broad.mit.edu	37	chr9	126143804	126143804	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcacgtcttgcttggttttCtgtaacaaatcctcaaaggg	8	10	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:126143804C>T	uc004bnz.1	-	22	3170	c.2937G>A	c.(2935-2937)CAG>CAA	p.Q979Q	DENND1A_uc011lzl.1_Silent_p.Q797Q|DENND1A_uc004bny.1_Silent_p.Q761Q|DENND1A_uc011lzm.1_Silent_p.Q990Q|DENND1A_uc010mwh.1_Silent_p.Q400Q	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	979	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						GCTTGGTTTTCTGTAACAAAT	0.647													0	0	0	0.004482	0	9	39										T	126143804	C	T	126143804	2	4	87	1	0	0	0	0	0	0	0	1	4426	912	32	1		1	DENND1A	9	126143804	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2242951	126143804	15069627	274	25942										
CRAT	1384	broad.mit.edu	37	chr9	131860309	131860309	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caccgtgacgctggagtcatCcatggccttgacaaaggtga	12	11	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:131860309C>T	uc004bxh.2	-	11	1729	c.1447G>A	c.(1447-1449)GAT>AAT	p.D483N	CRAT_uc004bxg.2_Missense_Mutation_p.D462N|CRAT_uc004bxk.3_Missense_Mutation_p.D462N	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	483					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	CTGGAGTCATCCATGGCCTTG	0.542													0	0	0	0.006214	0	9	129										T	131860309	C	T	131860309	3	4	87	1	0	0	0	0	1	0	0	0	3847	855	30	1	449	1	CRAT	9	131860309	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5716505	131860309	9353122	275	25943										
PTGDS	5730	broad.mit.edu	37	chr9	139873474	139873474	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgctggttcagcgcgggcctCgcctccaactcgagctggct	13	16	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:139873474C>T	uc004cke.2	+	2	219	c.144C>T	c.(142-144)CTC>CTT	p.L48L	PTGDS_uc004ckd.2_RNA|PTGDS_uc004ckf.2_RNA	NM_000954	NP_000945	P41222	PTGDS_HUMAN	prostaglandin D2 synthase, brain	48					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			ovary(1)	1	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCGCGGGCCTCGCCTCCAACT	0.711													0	0	0	0.009096	0	4	31										T	139873474	C	T	139873474	2	4	87	1	0	0	0	0	0	0	0	1	12742	871	31	1		1	PTGDS	9	139873474	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	8013165	139873474	1339957	276	25944										
ABCA2	20	broad.mit.edu	37	chr9	139908491	139908491	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagggcctctgcctccacctCtgtgcagagaggtagaggct	13	13	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:139908491C>T	uc011mem.1	-	27	4386	c.4238_splice	c.e27-1	p.E1413_splice	ABCA2_uc011mel.1_Splice_Site_p.E1414_splice|ABCA2_uc004ckl.1_Splice_Site_p.E1344_splice|ABCA2_uc004ckm.1_Splice_Site_p.E1444_splice|ABCA2_uc004ckn.1_Splice_Site	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCCTCCACCTCTGTGCAGAGA	0.682													0	0	0	0.00308	0	7	17										T	139908491	C	T	139908491	5	4	87	1	0	0	0	0	0	0	1	0	32	927	32	1	3158	1	ABCA2	9	139908491	Splice_Site	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	35017	139908491	1304940	277	25945										
C10orf18	54906	broad.mit.edu	37	chr10	5789126	5789126	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acaagaatggtccaaacactGaaaatatgaatttggaagcg	9	6	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:5789126G>A	uc001iij.2	+	15	4367	c.3742G>A	c.(3742-3744)GAA>AAA	p.E1248K	C10orf18_uc001iik.2_Missense_Mutation_p.E92K	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1248										ovary(1)|central_nervous_system(1)	2						TCCAAACACTGAAAATATGAA	0.408													0	0	0	0.01441	0	48	83										A	5789126	G	A	5789126	3	1	87	1	0	0	0	0	1	0	0	0	1596	1291	45	1	3788	1	C10orf18	10	5789126	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		5789126	129745621	278	25946										
IL2RA	3559	broad.mit.edu	37	chr10	6104059	6104059	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acaggcccttacctgcctggCagccaggcaccatgatgaac	10	15	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:6104059C>T	uc001iiz.1	-	1	215	c.56G>A	c.(55-57)TGC>TAC	p.C19Y	IL2RA_uc009xih.1_Missense_Mutation_p.C19Y	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	19					cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ACCTGCCTGGCAGCCAGGCAC	0.612													0	0	0	0.008291	0	9	87										T	6104059	C	T	6104059	3	4	87	1	0	0	0	0	1	0	0	0	7686	710	25	2	794	2	IL2RA	10	6104059	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	314933	6104059	129430688	279	25947										
NSUN6	221078	broad.mit.edu	37	chr10	18940106	18940106	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tagttttcaacctcaggtctCaaagatatcttagggaaaat	7	7	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:18940106C>G	uc010qcp.1	-	1	445	c.27G>C	c.(25-27)TTG>TTC	p.L9F		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	9							methyltransferase activity|RNA binding			ovary(2)	2						CCTCAGGTCTCAAAGATATCT	0.333													0	0	0	0.011902	0	41	81										G	18940106	C	G	18940106	3	3	87	1	0	0	0	0	1	0	0	0	10682	825	29	1	1426	1	NSUN6	10	18940106	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	12836047	18940106	116594641	280	25948										
SVIL	6840	broad.mit.edu	37	chr10	29747377	29747377	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcttacctcgaagtcttcgtCggtgagatagatctcaagct	10	10	2	2	rs147020336		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:29747377C>T	uc001iut.1	-	37	7297	c.6544G>A	c.(6544-6546)GAC>AAC	p.D2182N	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.D1096N|SVIL_uc001iuu.1_Missense_Mutation_p.D1756N	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2182	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AAGTCTTCGTCGGTGAGATAG	0.597													0	0	0	0.000602	0	5	44										T	29747377	C	T	29747377	3	4	87	1	0	0	0	0	1	0	0	0	15418	884	31	1	108	1	SVIL	10	29747377	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10807271	29747377	105787370	281	25949										
ITGB1	3688	broad.mit.edu	37	chr10	33201009	33201009	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcttcactgttaacttcatCtgtgctgcattcacaatgtc	6	11	5	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:33201009C>G	uc001iws.3	-	12	1649	c.1513G>C	c.(1513-1515)GAT>CAT	p.D505H	ITGB1_uc001iwp.3_Missense_Mutation_p.D505H|ITGB1_uc001iwq.3_Missense_Mutation_p.D505H|ITGB1_uc001iwr.3_Missense_Mutation_p.D505H|ITGB1_uc001iwt.3_Missense_Mutation_p.D505H|ITGB1_uc001iwu.1_Missense_Mutation_p.D505H	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	505	Extracellular (Potential).|I.|Cysteine-rich tandem repeats.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTAACTTCATCTGTGCTGCAT	0.398													0	0	0	0.013537	0	13	46										G	33201009	C	G	33201009	3	3	87	1	0	0	0	0	1	0	0	0	7890	913	32	1	1141	1	ITGB1	10	33201009	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3453632	33201009	102333738	282	25950										
GDF2	2658	broad.mit.edu	37	chr10	48413872	48413872	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgtcctcgaagtttacccgCagggaggtcttttgacagtg	12	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:48413872C>T	uc001jfa.1	-	2	1159	c.996G>A	c.(994-996)CTG>CTA	p.L332L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	332					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						AGTTTACCCGCAGGGAGGTCT	0.612													0	0	0	0.00499	0	16	81										T	48413872	C	T	48413872	2	4	87	1	0	0	0	0	0	0	0	1	6314	697	25	2		2	GDF2	10	48413872	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	15212863	48413872	87120875	283	25951										
FRMPD2	143162	broad.mit.edu	37	chr10	49440294	49440294	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccgttcagcaggaccacacaGaggtccctgagagccaaata	10	13	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:49440294G>A	uc001jgi.2	-	10	1139	c.1032C>T	c.(1030-1032)CTC>CTT	p.L344L	FRMPD2_uc001jgh.2_Silent_p.L313L|FRMPD2_uc001jgj.2_Silent_p.L322L	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	344	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		GGACCACACAGAGGTCCCTGA	0.383													0	0	0	0.008871	0	20	46										A	49440294	G	A	49440294	2	1	87	1	0	0	0	0	0	0	0	1	6058	929	33	1		1	FRMPD2	10	49440294	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1026422	49440294	86094453	284	25952										
OGDHL	55753	broad.mit.edu	37	chr10	50944540	50944540	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccgtgctgcggccccatcttCaggaatcacccgctggaagc	11	16	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:50944540C>G	uc001jie.2	-	21	2759	c.2617G>C	c.(2617-2619)GAA>CAA	p.E873Q	OGDHL_uc009xog.2_Missense_Mutation_p.E900Q|OGDHL_uc010qgt.1_Missense_Mutation_p.E816Q|OGDHL_uc010qgu.1_Missense_Mutation_p.E664Q	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	873					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GCCCCATCTTCAGGAATCACC	0.637													0	0	0	0.007413	0	19	71										G	50944540	C	G	50944540	3	3	87	1	0	0	0	0	1	0	0	0	10840	835	29	1	427	1	OGDHL	10	50944540	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1504246	50944540	84590207	285	25953										
NCOA4	8031	broad.mit.edu	37	chr10	51584673	51584673	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggggaaacctaaagggcttaGaaaactggctcctcaagagt	12	8	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:51584673G>C	uc001jis.3	+	8	975	c.772G>C	c.(772-774)GAA>CAA	p.E258Q	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.E274Q|NCOA4_uc010qhd.1_Missense_Mutation_p.E274Q|NCOA4_uc010qhe.1_Missense_Mutation_p.E158Q|NCOA4_uc010qhf.1_Missense_Mutation_p.E92Q|NCOA4_uc001jit.2_Missense_Mutation_p.E258Q|NCOA4_uc009xoo.2_Missense_Mutation_p.E258Q	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	258					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						AAAGGGCTTAGAAAACTGGCT	0.383			T	RET	papillary thyroid 								0	0	0	0.010504	0	21	107										C	51584673	G	C	51584673	3	2	87	1	0	0	0	0	1	0	0	0	10231	943	33	1	850	1	NCOA4	10	51584673	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	640133	51584673	83950074	286	25954										
ANK3	288	broad.mit.edu	37	chr10	61926588	61926588	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaacattttcataccttcatCatcagacatatcaagaactt	3	10	5	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:61926588C>T	uc001jky.2	-	22	2737	c.2545G>A	c.(2545-2547)GAT>AAT	p.D849N	ANK3_uc001jkx.2_Missense_Mutation_p.D27N|ANK3_uc010qih.1_Missense_Mutation_p.D832N|ANK3_uc001jkz.3_Missense_Mutation_p.D843N|ANK3_uc001jlb.1_Missense_Mutation_p.D378N|ANK3_uc001jlc.1_Missense_Mutation_p.D510N	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	849					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ATACCTTCATCATCAGACATA	0.333													0	0	0	0.004656	0	24	60										T	61926588	C	T	61926588	3	4	87	1	0	0	0	0	1	0	0	0	622	826	29	1	11009	1	ANK3	10	61926588	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10341915	61926588	73608159	287	25955										
SLC25A16	8034	broad.mit.edu	37	chr10	70276532	70276532	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgcttgtaatggtgattgtGagcttgtaataaaaccttta	9	4	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:70276532G>A	uc001joi.2	-	2	651	c.199C>T	c.(199-201)CAC>TAC	p.H67Y	SLC25A16_uc010qix.1_5'UTR|SLC25A16_uc010qiy.1_5'UTR|SLC25A16_uc001joj.2_5'UTR	NM_152707	NP_689920	P16260	GDC_HUMAN	solute carrier family 25, member 16	67	Solcar 1.				coenzyme biosynthetic process|pantothenate metabolic process	integral to membrane|mitochondrial inner membrane	binding|solute:solute antiporter activity				0						TGGTGATTGTGAGCTTGTAAT	0.333													0	0	0	0.00245	0	15	33										A	70276532	G	A	70276532	3	1	87	1	0	0	0	0	1	0	0	0	14478	1290	45	1	831	1	SLC25A16	10	70276532	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	8349944	70276532	65258215	288	25956										
ANXA11	311	broad.mit.edu	37	chr10	81932588	81932588	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcagctggtgggtagccaccTgggggcgggggatagccagg	21	9	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:81932588T>C	uc001kbq.1	-	4	855	c.30A>G	c.(28-30)CCA>CCG	p.P10P	ANXA11_uc010qlx.1_5'Flank|ANXA11_uc001kbr.1_Silent_p.P10P|ANXA11_uc001kbs.1_Silent_p.P10P|ANXA11_uc001kbt.1_Silent_p.P10P|ANXA11_uc010qly.1_5'UTR|ANXA11_uc009xsq.1_Silent_p.P10P|ANXA11_uc001kbu.1_Silent_p.P10P	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	10					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			GGTAGCCACCTGGGGGCGGGG	0.617													0	0	0	0.009535	0	27	61										C	81932588	T	C	81932588	2	2	87	1	0	0	0	0	0	0	0	1	716	1567	55	5		5	ANXA11	10	81932588	Silent	SNP	T	TCGA-FD-A3SS-01A-12D-A22Z-08	11656056	81932588	53602159	289	25957										
BMPR1A	657	broad.mit.edu	37	chr10	88651946	88651946	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggagaaaccacattagcttCagggtgtatgaaatatgaag	12	5	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:88651946C>T	uc001kdy.2	+	5	841	c.293C>T	c.(292-294)TCA>TTA	p.S98L		NM_004329	NP_004320	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	98	Extracellular (Potential).				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8						ACATTAGCTTCAGGGTGTATG	0.333			Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				0	0	0	0.004482	0	9	28										T	88651946	C	T	88651946	3	4	87	1	0	0	0	0	1	0	0	0	1469	838	29	1	303	1	BMPR1A	10	88651946	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6719358	88651946	46882801	290	25958										
IFIT2	3433	broad.mit.edu	37	chr10	91066692	91066692	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggctcatctgaagaaagctGatgaggccaatgataatctc	10	8	3	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:91066692G>A	uc009xts.2	+	2	1154	c.979G>A	c.(979-981)GAT>AAT	p.D327N	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	327					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				GAAGAAAGCTGATGAGGCCAA	0.418													0	0	0	0.001168	0	6	58										A	91066692	G	A	91066692	3	1	87	1	0	0	0	0	1	0	0	0	7523	1290	45	1	985	1	IFIT2	10	91066692	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2414746	91066692	44468055	291	25959										
KIF20B	9585	broad.mit.edu	37	chr10	91469117	91469117	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tctagggctgtgtgcatattCtggattcacagactgttgtg	12	7	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:91469117C>T	uc001kgs.1	+	4	322	c.250C>T	c.(250-252)CTG>TTG	p.L84L	KIF20B_uc001kgr.1_Silent_p.L84L	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	84	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TGTGCATATTCTGGATTCACA	0.348													0	0	0	0.01441	0	61	44										T	91469117	C	T	91469117	2	4	87	1	0	0	0	0	0	0	0	1	8287	912	32	1		1	KIF20B	10	91469117	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	402425	91469117	44065630	292	25960										
SORBS1	10580	broad.mit.edu	37	chr10	97096663	97096663	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agctatcttggtggatgcctGaagatggcgtgtggacacca	14	8	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:97096663G>A	uc001kkp.2	-	28	3299	c.3254C>T	c.(3253-3255)TCA>TTA	p.S1085L	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.S1039L|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1085					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GTGGATGCCTGAAGATGGCGT	0.562													0	0	0	0.000602	0	5	27										A	97096663	G	A	97096663	3	1	87	1	0	0	0	0	1	0	0	0	14927	1294	45	1	704	1	SORBS1	10	97096663	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5627546	97096663	38438084	293	25961										
SORBS1	10580	broad.mit.edu	37	chr10	97101052	97101052	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcagcttacctttctgaagGacatttctacttgtgtatca	7	9	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:97101052G>A	uc001kkp.2	-	26	2705	c.2660C>T	c.(2659-2661)TCC>TTC	p.S887F	SORBS1_uc001kkk.2_Missense_Mutation_p.S381F|SORBS1_uc001kkl.2_Missense_Mutation_p.S489F|SORBS1_uc001kkn.2_Missense_Mutation_p.S652F|SORBS1_uc001kkm.2_Missense_Mutation_p.S687F|SORBS1_uc001kko.2_Missense_Mutation_p.S909F|SORBS1_uc001kkq.2_Missense_Mutation_p.S738F|SORBS1_uc001kkr.2_Missense_Mutation_p.S593F|SORBS1_uc001kks.2_Missense_Mutation_p.S537F|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Missense_Mutation_p.S634F|SORBS1_uc001kkv.2_Missense_Mutation_p.S669F|SORBS1_uc001kkw.2_Missense_Mutation_p.S841F|SORBS1_uc010qoe.1_Missense_Mutation_p.S602F	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	887	SH3 2.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTTTCTGAAGGACATTTCTAC	0.468													0	0	0	0.001168	0	6	98										A	97101052	G	A	97101052	3	1	87	1	0	0	0	0	1	0	0	0	14927	1174	41	1	1306	1	SORBS1	10	97101052	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4389	97101052	38433695	294	25962										
C10orf12	26148	broad.mit.edu	37	chr10	98742417	98742417	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaagcatcagtgctgaggttGagtctggagacacccaggag	14	8	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:98742417G>C	uc001kmv.2	+	1	1377	c.1270G>C	c.(1270-1272)GAG>CAG	p.E424Q	C10orf12_uc009xvg.1_Missense_Mutation_p.E734Q	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	424										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGCTGAGGTTGAGTCTGGAGA	0.512													0	0	0	0.008291	0	10	150										C	98742417	G	C	98742417	3	2	87	1	0	0	0	0	1	0	0	0	1589	1291	45	1	1272	1	C10orf12	10	98742417	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1641365	98742417	36792330	295	25963										
FAM178A	55719	broad.mit.edu	37	chr10	102689105	102689105	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcagaagcaactacaagaaGacataaggcaaggccgaggc	12	9	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102689105G>T	uc001krt.3	+	7	2616	c.2074G>T	c.(2074-2076)GAC>TAC	p.D692Y	FAM178A_uc001krs.2_Missense_Mutation_p.D692Y	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	692											0						ACTACAAGAAGACATAAGGCA	0.363													1	0	1.5739e-10	0.004007	1.67292e-10	16	10										T	102689105	G	T	102689105	3	4	87	1	0	0	0	0	1	0	0	0	5503	942	33	3	2100	3	FAM178A	10	102689105	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3946688	102689105	32845642	296	25964										
SEMA4G	57715	broad.mit.edu	37	chr10	102740934	102740934	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttctgtcccaggacagcactGatacaggacatagagagagg	12	9	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102740934G>C	uc001krw.1	+	13	2037	c.1653G>C	c.(1651-1653)CTG>CTC	p.L551L	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Silent_p.L551L|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	546	Extracellular (Potential).|PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		GGACAGCACTGATACAGGACA	0.473													0	0	0	0.000602	0	5	35										C	102740934	G	C	102740934	2	2	87	1	0	0	0	0	0	0	0	1	14036	1277	45	1		1	SEMA4G	10	102740934	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	51829	102740934	32793813	297	25965										
SFXN4	119559	broad.mit.edu	37	chr10	120923669	120923669	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatgaacacatttgtaggatCtaataattctgtccattgaa	6	6	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:120923669C>G	uc001leb.2	-	2	196	c.151G>C	c.(151-153)GAT>CAT	p.D51H	SFXN4_uc001ldz.2_5'UTR|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	51					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		TTTGTAGGATCTAATAATTCT	0.318													0	0	0	0.01441	0	49	30										G	120923669	C	G	120923669	3	3	87	1	0	0	0	0	1	0	0	0	14197	913	32	1	914	1	SFXN4	10	120923669	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	18182735	120923669	14611078	298	25966										
PSMA1	5682	broad.mit.edu	37	chr11	14529258	14529258	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggaatggagacacatcatCatcatcatagattgtaaact	7	8	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:14529258C>T	uc001mlk.2	-	9	825	c.679G>A	c.(679-681)GAT>AAT	p.D227N	PSMA1_uc001mll.2_Missense_Mutation_p.D233N|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.D202N	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	227					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						GACACATCATCATCATCATAG	0.353													0	0	0	0.007291	0	26	21										T	14529258	C	T	14529258	3	4	87	1	0	0	0	0	1	0	0	0	12666	826	29	1	120	1	PSMA1	11	14529258	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		14529258	120477258	299	25967										
INSC	387755	broad.mit.edu	37	chr11	15199878	15199878	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcttctcttcaggtgccttcAggttgagaatgagcatgtcc	10	10	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:15199878A>C	uc001mly.2	+	5	651	c.605A>C	c.(604-606)CAG>CCG	p.Q202P	INSC_uc001mlz.2_Missense_Mutation_p.Q155P|INSC_uc001mma.2_Missense_Mutation_p.Q155P|INSC_uc010rcs.1_Missense_Mutation_p.Q155P|INSC_uc001mmb.2_Missense_Mutation_p.Q155P|INSC_uc001mmc.2_Missense_Mutation_p.Q155P	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	202					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						AGGTGCCTTCAGGTTGAGAAT	0.572													0	0	0	0.012213	0	31	15										C	15199878	A	C	15199878	3	2	87	1	0	0	0	0	1	0	0	0	7764	188	7	5	623	5	INSC	11	15199878	Missense_Mutation	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	670620	15199878	119806638	300	25968										
SPTY2D1	144108	broad.mit.edu	37	chr11	18636604	18636604	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgattgatcgctcaggtcctGagctggagctgccattctgg	13	10	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:18636604G>C	uc001moy.2	-	3	1433	c.1217C>G	c.(1216-1218)TCA>TGA	p.S406*	SPTY2D1_uc010rdi.1_Nonsense_Mutation_p.S406*	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	406	Ser-rich.									breast(1)	1						CTCAGGTCCTGAGCTGGAGCT	0.592													0	0	0	0.008291	0	11	70										C	18636604	G	C	18636604	4	2	87	1	0	0	0	0	0	1	0	0	15125	1294	45	1	856	1	SPTY2D1	11	18636604	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3436726	18636604	116369912	301	25969										
SLC17A6	57084	broad.mit.edu	37	chr11	22360119	22360119	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggattttggccccaggaaaaGaggggctaaagaattttgct	13	6	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:22360119G>A	uc001mqk.2	+	1	453	c.40G>A	c.(40-42)GAG>AAG	p.E14K		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	14	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						CCCAGGAAAAGAGGGGCTAAA	0.438													0	0	0	0.00499	0	14	24										A	22360119	G	A	22360119	3	1	87	1	0	0	0	0	1	0	0	0	14421	943	33	1	42	1	SLC17A6	11	22360119	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3723515	22360119	112646397	302	25970										
LUZP2	338645	broad.mit.edu	37	chr11	24759813	24759813	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccctgcaaaatcagcttaagGagacatcagagaaagcagaa	9	9	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:24759813G>A	uc001mqs.2	+	4	532	c.298G>A	c.(298-300)GAG>AAG	p.E100K	LUZP2_uc009yif.2_Missense_Mutation_p.E14K|LUZP2_uc009yig.2_Missense_Mutation_p.E100K	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	100	Potential.					extracellular region				ovary(1)|skin(1)	2						TCAGCTTAAGGAGACATCAGA	0.363													0	0	0	0.00308	0	6	20										A	24759813	G	A	24759813	3	1	87	1	0	0	0	0	1	0	0	0	9087	1175	41	1	312	1	LUZP2	11	24759813	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2399694	24759813	110246703	303	25971										
COMMD9	29099	broad.mit.edu	37	chr11	36302292	36302292	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcctcctgggtcacagacaaGctggaacatgtaacatccaa	8	12	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:36302292G>A	uc001mwn.3	-	2	184	c.147C>T	c.(145-147)AGC>AGT	p.S49S	COMMD9_uc009ykj.2_Intron|COMMD9_uc010rfb.1_Silent_p.S49S	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	49										ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				TCACAGACAAGCTGGAACATG	0.468													0	0	0	0.001168	0	6	68										A	36302292	G	A	36302292	2	1	87	1	0	0	0	0	0	0	0	1	3723	962	34	2		2	COMMD9	11	36302292	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11542479	36302292	98704224	304	25972										
ACCS	84680	broad.mit.edu	37	chr11	44098828	44098828	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcgcccactcctgcccccaGaggctttcctgatccccacc	6	22	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:44098828G>A	uc009yks.1	+	7	701	c.557_splice	c.e7-1	p.E186_splice	EXT2_uc010rfo.1_Intron|ACCS_uc010rfm.1_Intron|ACCS_uc010rfn.1_Splice_Site|ACCS_uc001mxx.2_Splice_Site_p.E186_splice	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase								1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						CCTGCCCCCAGAGGCTTTCCT	0.577													0	0	0	0.012319	0	21	91										A	44098828	G	A	44098828	5	1	87	1	0	0	0	0	0	0	1	0	133	956	33	1	578	1	ACCS	11	44098828	Splice_Site	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7796536	44098828	90907688	305	25973										
OR5T1	390155	broad.mit.edu	37	chr11	56043601	56043601	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcatcactgcttcctatgttGctagcattttacatgctact	5	11	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:56043601G>A	uc001nio.1	+	1	487	c.487G>A	c.(487-489)GCT>ACT	p.A163T		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	163	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTCCTATGTTGCTAGCATTTT	0.428													0	0	0	0.01441	0	101	170										A	56043601	G	A	56043601	3	1	87	1	0	0	0	0	1	0	0	0	11181	1319	46	2	489	2	OR5T1	11	56043601	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11944773	56043601	78962915	306	25974										
PCNXL3	399909	broad.mit.edu	37	chr11	65393495	65393495	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtcacagcccgtgctgaagCcgctggagtacagccagtat	12	12	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:65393495C>T	uc001oey.2	+	20	3349	c.3349C>T	c.(3349-3351)CCG>TCG	p.P1117S	PCNXL3_uc009yqn.2_Missense_Mutation_p.P77S|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1117						integral to membrane					0						CGTGCTGAAGCCGCTGGAGTA	0.647											OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	13										T	65393495	C	T	65393495	3	4	87	1	0	0	0	0	1	0	0	0	11593	739	26	2	3427	2	PCNXL3	11	65393495	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9349894	65393495	69613021	307	25975										
SIPA1	6494	broad.mit.edu	37	chr11	65412521	65412521	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggaggcgggaccggccttCatgcagtttctcaccttgct	12	13	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:65412521C>T	uc001ofb.2	+	5	1247	c.1080C>T	c.(1078-1080)TTC>TTT	p.F360F	SIPA1_uc010rom.1_Silent_p.F360F|SIPA1_uc001ofd.2_Silent_p.F360F	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	360	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GACCGGCCTTCATGCAGTTTC	0.622													0	0	0	0.003954	0	25	107										T	65412521	C	T	65412521	2	4	87	1	0	0	0	0	0	0	0	1	14328	825	29	1		1	SIPA1	11	65412521	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	19026	65412521	69593995	308	25976										
CCDC87	55231	broad.mit.edu	37	chr11	66360334	66360334	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agcgacgccaccgtcagcttCgccagagggaaggactgcag	14	13	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66360334C>T	uc001oiq.3	-	1	221	c.153G>A	c.(151-153)GCG>GCA	p.A51A	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	51										ovary(1)|skin(1)	2						CCGTCAGCTTCGCCAGAGGGA	0.677											OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	49										T	66360334	C	T	66360334	2	4	87	1	0	0	0	0	0	0	0	1	2862	871	31	1		1	CCDC87	11	66360334	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	947813	66360334	68646182	309	25977										
SPTBN2	6712	broad.mit.edu	37	chr11	66456633	66456633	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctggcgccgtgcctgcagctGagacagcttctctgagatct	12	13	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66456633G>A	uc001ojd.2	-	29	6040	c.5968C>T	c.(5968-5970)CAG>TAG	p.Q1990*	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1990	Spectrin 16.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCCTGCAGCTGAGACAGCTTC	0.632													0	0	0	0.009096	0	3	14										A	66456633	G	A	66456633	4	1	87	1	0	0	0	0	0	1	0	0	15119	1299	45	1	1240	1	SPTBN2	11	66456633	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	96299	66456633	68549883	310	25978										
SSH3	54961	broad.mit.edu	37	chr11	67075889	67075889	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccctctctcccagggctcaGagtggaacgcagcaaacctg	10	15	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:67075889G>C	uc001okj.2	+	10	1199	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Missense_Mutation_p.E195Q	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	341	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCAGGGCTCAGAGTGGAACGC	0.657													0	0	0	0.00308	0	7	23										C	67075889	G	C	67075889	3	2	87	1	0	0	0	0	1	0	0	0	15185	943	33	1	1059	1	SSH3	11	67075889	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	619256	67075889	67930627	311	25979										
MRGPRF	116535	broad.mit.edu	37	chr11	68773711	68773711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctgtagagttccggggcctCgctcaggccagggcacatct	14	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:68773711C>T	uc001ooo.3	-	3	434	c.67G>A	c.(67-69)GAG>AAG	p.E23K	MRGPRF_uc001oop.3_Missense_Mutation_p.E23K	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	23	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCCGGGGCCTCGCTCAGGCCA	0.667													0	0	0	0.004007	0	16	36										T	68773711	C	T	68773711	3	4	87	1	0	0	0	0	1	0	0	0	9765	893	31	1	968	1	MRGPRF	11	68773711	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1697822	68773711	66232805	312	25980										
TPCN2	219931	broad.mit.edu	37	chr11	68838873	68838873	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gccatcatctacagtcagttCcggggctacctgatggtgag	12	11	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:68838873C>T	uc001oos.2	+	10	1061	c.945C>T	c.(943-945)TTC>TTT	p.F315F	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Silent_p.F230F|TPCN2_uc010rqg.1_Silent_p.F315F|TPCN2_uc001oot.2_5'Flank	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	315	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACAGTCAGTTCCGGGGCTACC	0.597													0	0	0	0.009096	0	3	11										T	68838873	C	T	68838873	2	4	87	1	0	0	0	0	0	0	0	1	16393	854	30	1		1	TPCN2	11	68838873	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	65162	68838873	66167643	313	25981										
PPFIA1	8500	broad.mit.edu	37	chr11	70200458	70200458	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acaagacaaccataaagtgtGaaacctccccgccttcctcc	5	16	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:70200458G>A	uc001opo.2	+	17	2413	c.2215G>A	c.(2215-2217)GAA>AAA	p.E739K	PPFIA1_uc001opn.1_Missense_Mutation_p.E739K|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	739					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CATAAAGTGTGAAACCTCCCC	0.532													0	0	0	0.000602	0	5	50										A	70200458	G	A	70200458	3	1	87	1	0	0	0	0	1	0	0	0	12309	1291	45	1	2277	1	PPFIA1	11	70200458	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1361585	70200458	64806058	314	25982										
C2CD3	26005	broad.mit.edu	37	chr11	73825601	73825601	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtcatcgtttgggcatcttCtggagtttctgagagcatct	11	8	5	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:73825601C>T	uc001ouu.2	-	10	1785	c.1558G>A	c.(1558-1560)GAA>AAA	p.E520K	C2CD3_uc001ouv.2_Missense_Mutation_p.E520K	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	520						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TGGGCATCTTCTGGAGTTTCT	0.443													0	0	0	0.010504	0	19	83										T	73825601	C	T	73825601	3	4	87	1	0	0	0	0	1	0	0	0	2154	922	32	1	4421	1	C2CD3	11	73825601	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3625143	73825601	61180915	315	25983										
MYO7A	4647	broad.mit.edu	37	chr11	76892492	76892492	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggagaaggaggccgctcggCggaagaaggagctcctggag	19	8	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:76892492C>T	uc001oyb.2	+	23	3033	c.2761C>T	c.(2761-2763)CGG>TGG	p.R921W	MYO7A_uc010rsl.1_Missense_Mutation_p.R921W|MYO7A_uc010rsm.1_Missense_Mutation_p.R910W|MYO7A_uc001oyc.2_Missense_Mutation_p.R921W|MYO7A_uc001oyd.2_Missense_Mutation_p.R261W|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.R132W	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	921	Potential.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GGCCGCTCGGCGGAAGAAGGA	0.617													0	0	0	0.001168	0	6	10										T	76892492	C	T	76892492	3	4	87	1	0	0	0	0	1	0	0	0	10082	759	27	2	2847	2	MYO7A	11	76892492	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3066891	76892492	58114024	316	25984										
C11orf82	220042	broad.mit.edu	37	chr11	82643638	82643638	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggatgatctgccattctctGaaagcctgaacaagtttctg	10	9	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:82643638G>A	uc001ozt.2	+	6	1502	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	C11orf82_uc010rsr.1_Missense_Mutation_p.E119K|C11orf82_uc010rss.1_Missense_Mutation_p.E119K|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	420					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						GCCATTCTCTGAAAGCCTGAA	0.443													0	0	0	0.004007	0	17	144										A	82643638	G	A	82643638	3	1	87	1	0	0	0	0	1	0	0	0	1665	1291	45	1	1272	1	C11orf82	11	82643638	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5751146	82643638	52362878	317	25985										
CREBZF	58487	broad.mit.edu	37	chr11	85374910	85374910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acgccgagcagaactccaccGacaccttatccttgtccaca	6	17	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85374910G>A	uc001pas.2	-	1	1273	c.1010C>T	c.(1009-1011)TCG>TTG	p.S337L	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	337					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GAACTCCACCGACACCTTATC	0.562											OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	21	122										A	85374910	G	A	85374910	3	1	87	1	0	0	0	0	1	0	0	0	3863	1059	37	1	58	1	CREBZF	11	85374910	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2731272	85374910	49631606	318	25986										
SYTL2	54843	broad.mit.edu	37	chr11	85438975	85438975	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agaactgccacctggcacctGagatggctcaggctcaacac	10	14	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85438975G>C	uc010rth.1	-	7	1699	c.1423C>G	c.(1423-1425)CAG>GAG	p.Q475E	SYTL2_uc010rtg.1_Missense_Mutation_p.Q476E|SYTL2_uc010rti.1_Missense_Mutation_p.Q475E|SYTL2_uc010rtj.1_Missense_Mutation_p.Q427E|SYTL2_uc009yvj.2_5'Flank|SYTL2_uc001pbd.2_5'Flank|SYTL2_uc001pbb.2_5'Flank|SYTL2_uc001pbc.2_5'Flank|SYTL2_uc010rtf.1_Missense_Mutation_p.Q333E	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	475					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCTGGCACCTGAGATGGCTCA	0.453													0	0	0	0.00499	0	14	27										C	85438975	G	C	85438975	3	2	87	1	0	0	0	0	1	0	0	0	15480	1299	45	1	3910	1	SYTL2	11	85438975	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	64065	85438975	49567541	319	25987										
SYTL2	54843	broad.mit.edu	37	chr11	85445719	85445719	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggcctggcaaagtctgctttGatttctctaacttttggatt	9	8	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85445719G>A	uc010rth.1	-	6	926	c.650C>T	c.(649-651)TCA>TTA	p.S217L	SYTL2_uc010rtg.1_Missense_Mutation_p.S218L|SYTL2_uc010rti.1_Missense_Mutation_p.S217L|SYTL2_uc010rtj.1_Missense_Mutation_p.S169L|SYTL2_uc001pbf.3_Missense_Mutation_p.S217L|SYTL2_uc010rtf.1_Missense_Mutation_p.S75L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	217					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AGTCTGCTTTGATTTCTCTAA	0.368													0	0	0	0.004878	0	35	66										A	85445719	G	A	85445719	3	1	87	1	0	0	0	0	1	0	0	0	15480	1294	45	1	4687	1	SYTL2	11	85445719	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6744	85445719	49560797	320	25988										
GRM5	2915	broad.mit.edu	37	chr11	88583124	88583124	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccaggcgcctcatggccatCagcagacctctcaccgtcat	8	18	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:88583124C>T	uc001pcq.2	-	2	1061	c.861G>A	c.(859-861)CTG>CTA	p.L287L	GRM5_uc009yvm.2_Silent_p.L287L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	287	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TCATGGCCATCAGCAGACCTC	0.517													0	0	0	0.012213	0	35	50										T	88583124	C	T	88583124	2	4	87	1	0	0	0	0	0	0	0	1	6800	813	29	1		1	GRM5	11	88583124	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3137405	88583124	46423392	321	25989										
HEPHL1	341208	broad.mit.edu	37	chr11	93821974	93821974	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acctctcgagaggcatgggtCagatctatgaggtcagcagc	13	10	4	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:93821974C>G	uc001pep.2	+	12	2291	c.2134C>G	c.(2134-2136)CAG>GAG	p.Q712E	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	712	Plastocyanin-like 4.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGGCATGGGTCAGATCTATGA	0.502													0	0	0	0.004007	0	17	35										G	93821974	C	G	93821974	3	3	87	1	0	0	0	0	1	0	0	0	7055	827	29	1	2180	1	HEPHL1	11	93821974	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5238850	93821974	41184542	322	25990										
PCSK7	9159	broad.mit.edu	37	chr11	117094889	117094889	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggctaccacaaagatgctcCcaaagccctggcgaccagca	9	15	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:117094889C>G	uc001pqr.2	-	8	1160	c.959G>C	c.(958-960)GGG>GCG	p.G320A		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	320	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		AAAGATGCTCCCAAAGCCCTG	0.547			T	IGH@	MLCLS								0	0	0	0.00245	0	13	27										G	117094889	C	G	117094889	3	3	87	1	0	0	0	0	1	0	0	0	11605	623	22	4	1438	4	PCSK7	11	117094889	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	23272915	117094889	17911627	323	25991										
ZNF202	7753	broad.mit.edu	37	chr11	123597577	123597577	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagtctacctggattgtcctCaaagactatttcccaatctg	6	11	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:123597577C>T	uc001pzd.1	-	9	1475	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	ZNF202_uc001pzc.1_Missense_Mutation_p.E135K|ZNF202_uc001pze.1_Missense_Mutation_p.E359K|ZNF202_uc001pzf.1_Missense_Mutation_p.E359K	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	359					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GGATTGTCCTCAAAGACTATT	0.433													0	0	0	0.01441	0	79	134										T	123597577	C	T	123597577	3	4	87	1	0	0	0	0	1	0	0	0	17760	835	29	1	875	1	ZNF202	11	123597577	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6502688	123597577	11408939	324	25992										
OR8B12	219858	broad.mit.edu	37	chr11	124412979	124412979	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccaccagctcattcatgtaaGagctgttgcaggagagctca	10	11	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:124412979G>A	uc010sam.1	-	1	572	c.572C>T	c.(571-573)TCT>TTT	p.S191F		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		ATTCATGTAAGAGCTGTTGCA	0.458													0	0	0	0.013726	0	33	51										A	124412979	G	A	124412979	3	1	87	1	0	0	0	0	1	0	0	0	11226	942	33	1	362	1	OR8B12	11	124412979	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	815402	124412979	10593537	325	25993										
ADAMTS15	170689	broad.mit.edu	37	chr11	130319039	130319039	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagggactcatttttcagatCacagcatttcaggaggactt	9	9	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:130319039C>T	uc010scd.1	+	1	171	c.171C>T	c.(169-171)ATC>ATT	p.I57I		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	57					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TTTTTCAGATCACAGCATTTC	0.602													0	0	0	0.008291	0	11	76										T	130319039	C	T	130319039	2	4	87	1	0	0	0	0	0	0	0	1	260	816	29	1		1	ADAMTS15	11	130319039	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5906060	130319039	4687477	326	25994										
A2M	2	broad.mit.edu	37	chr12	9229990	9229990	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcgatggtgatataggcggaGagggtcacttcatcttctac	13	8	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:9229990G>A	uc001qvk.1	-	27	3416	c.3303C>T	c.(3301-3303)CTC>CTT	p.L1101L	A2M_uc001qvj.1_Silent_p.L143L|A2M_uc009zgk.1_Silent_p.L951L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1101					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TATAGGCGGAGAGGGTCACTT	0.453													0	0	0	0.001984	0	5	10										A	9229990	G	A	9229990	2	1	87	1	0	0	0	0	0	0	0	1	4	929	33	1		1	A2M	12	9229990	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		9229990	124621905	327	25995										
PRB1	5542	broad.mit.edu	37	chr12	11506649	11506649	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcctggaggtgggggaccttGaggtctgttgcctccttgtg	16	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:11506649G>A	uc001qzw.1	-	3	425	c.388C>T	c.(388-390)CAA>TAA	p.Q130*	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	191	7.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGGGACCTTGAGGTCTGTTG	0.617													0	0	0	0.01441	0	46	693										A	11506649	G	A	11506649	4	1	87	1	0	0	0	0	0	1	0	0	12442	1299	45	1	611	1	PRB1	12	11506649	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2276659	11506649	122345246	328	25996										
SLCO1C1	53919	broad.mit.edu	37	chr12	20903661	20903661	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgattgatacttcatgcctCaaatggggatttaaaagatg	9	5	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:20903661C>T	uc001rej.3	+	15	2206	c.1851C>T	c.(1849-1851)CTC>CTT	p.L617L	SLCO1C1_uc010sii.1_Silent_p.L617L|SLCO1C1_uc010sij.1_Silent_p.L568L|SLCO1C1_uc009zip.2_Silent_p.L451L|SLCO1C1_uc001rei.2_Silent_p.L617L|SLCO1C1_uc010sik.1_Silent_p.L499L	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	617	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CTTCATGCCTCAAATGGGGAT	0.363													0	0	0	0.006122	0	17	70										T	20903661	C	T	20903661	2	4	87	1	0	0	0	0	0	0	0	1	14725	813	29	1		1	SLCO1C1	12	20903661	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9397012	20903661	112948234	329	25997										
ADAMTS20	80070	broad.mit.edu	37	chr12	43825236	43825236	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acagaagccatcactcaagtGatctacattcagctgacacc	6	13	4	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:43825236G>A	uc010skx.1	-	22	3160	c.3160C>T	c.(3160-3162)CAC>TAC	p.H1054Y	ADAMTS20_uc001rno.1_Missense_Mutation_p.H208Y|ADAMTS20_uc001rnp.1_Missense_Mutation_p.H208Y	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1054	TSP type-1 5.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCACTCAAGTGATCTACATTC	0.428													0	0	0	0.01441	0	63	40										A	43825236	G	A	43825236	3	1	87	1	0	0	0	0	1	0	0	0	266	1290	45	1	2643	1	ADAMTS20	12	43825236	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	22921575	43825236	90026659	330	25998										
ADAMTS20	80070	broad.mit.edu	37	chr12	43944794	43944794	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agaagcagtggcgcaggtccGagggccctgcgtcgctctcc	15	14	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:43944794G>A	uc010skx.1	-	2	371	c.371C>T	c.(370-372)TCG>TTG	p.S124L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	124						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCGCAGGTCCGAGGGCCCTGC	0.667													0	0	0	0.010729	0	10	5										A	43944794	G	A	43944794	3	1	87	1	0	0	0	0	1	0	0	0	266	1059	37	1	5512	1	ADAMTS20	12	43944794	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	119558	43944794	89907101	331	25999										
SFRS2IP	9169	broad.mit.edu	37	chr12	46320089	46320089	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tatctgctggtgtatcaaatGagaactcctgttcacttttt	7	8	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:46320089G>A	uc001rox.2	-	11	3682	c.3395C>T	c.(3394-3396)TCA>TTA	p.S1132L	SFRS2IP_uc001row.2_Missense_Mutation_p.S817L|SFRS2IP_uc001roy.1_Missense_Mutation_p.S1206L	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1132					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TGTATCAAATGAGAACTCCTG	0.443													0	0	0	0.005443	0	27	83										A	46320089	G	A	46320089	3	1	87	1	0	0	0	0	1	0	0	0	14177	1294	45	1	1016	1	SFRS2IP	12	46320089	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2375295	46320089	87531806	332	26000										
KRT4	3851	broad.mit.edu	37	chr12	53207850	53207850	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtctggcaatcatggctgcaGagagcgagctgggagctatc	15	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53207850G>C	uc001saz.2	-	1	486	c.215C>G	c.(214-216)TCT>TGT	p.S72C		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	Error:Variant_position_missing_in_B4DRS2_after_alignment						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						CATGGCTGCAGAGAGCGAGCT	0.627													0	0	0	0.006122	0	17	33										C	53207850	G	C	53207850	3	2	87	1	0	0	0	0	1	0	0	0	8477	942	33	1	1605	1	KRT4	12	53207850	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6887761	53207850	80644045	333	26001										
KRT78	196374	broad.mit.edu	37	chr12	53242451	53242451	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggggtcagcagattctggttGatggtcacttcttggatgcc	14	8	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53242451G>A	uc001sbc.1	-	1	328	c.264C>T	c.(262-264)ATC>ATT	p.I88I		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	88	Head.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GATTCTGGTTGATGGTCACTT	0.622													0	0	0	0.003163	0	11	29										A	53242451	G	A	53242451	2	1	87	1	0	0	0	0	0	0	0	1	8491	1280	45	1		1	KRT78	12	53242451	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	34601	53242451	80609444	334	26002										
RARG	5916	broad.mit.edu	37	chr12	53607319	53607319	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggcgctgagcagccctgtctCggtgtcatccatctccaggg	13	14	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53607319C>T	uc001sce.2	-	8	1464	c.979G>A	c.(979-981)GAG>AAG	p.E327K	RARG_uc001scd.2_Missense_Mutation_p.E316K|RARG_uc010sob.1_Missense_Mutation_p.E305K|RARG_uc001scf.2_Missense_Mutation_p.E327K|RARG_uc001scg.2_Missense_Mutation_p.E255K|RARG_uc010soc.1_Missense_Mutation_p.E206K|RARG_uc010sod.1_Missense_Mutation_p.E364K	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	327	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AGCCCTGTCTCGGTGTCATCC	0.647											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	25	17										T	53607319	C	T	53607319	3	4	87	1	0	0	0	0	1	0	0	0	13054	893	31	1	397	1	RARG	12	53607319	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	364868	53607319	80244576	335	26003										
TRHDE	29953	broad.mit.edu	37	chr12	72956777	72956777	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccaacagcattttatctatGatatcagtgctaaaactaaa	4	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:72956777G>C	uc001sxa.2	+	9	1894	c.1864G>C	c.(1864-1866)GAT>CAT	p.D622H		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	622	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTTATCTATGATATCAGTGC	0.323													0	0	0	0.01441	0	58	41										C	72956777	G	C	72956777	3	2	87	1	0	0	0	0	1	0	0	0	16476	1290	45	1	1898	1	TRHDE	12	72956777	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	19349458	72956777	60895118	336	26004										
C12orf63	374467	broad.mit.edu	37	chr12	97157932	97157932	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atttgccatatttttagcctCctctcagaagaagtagttct	6	9	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:97157932C>T	uc001tet.1	+	26	3397	c.3319C>T	c.(3319-3321)CCT>TCT	p.P1107S		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1107										skin(6)|ovary(1)	7						TTTTTAGCCTCCTCTCAGAAG	0.308													0	0	0	0.001168	0	6	23										T	97157932	C	T	97157932	3	4	87	1	0	0	0	0	1	0	0	0	1706	855	30	1	3417	1	C12orf63	12	97157932	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	24201155	97157932	36693963	337	26005										
ATP2A2	488	broad.mit.edu	37	chr12	110778732	110778732	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaacgcccgctgttttgctcGagttgaaccctcccacaagt	9	14	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:110778732G>C	uc001tqk.3	+	14	2593	c.2030G>C	c.(2029-2031)CGA>CCA	p.R677P	ATP2A2_uc001tql.3_Missense_Mutation_p.R677P|ATP2A2_uc010sxy.1_Missense_Mutation_p.R650P	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	677	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TGTTTTGCTCGAGTTGAACCC	0.498													0	0	0	0.006214	0	9	24										C	110778732	G	C	110778732	3	2	87	1	0	0	0	0	1	0	0	0	1137	1058	37	1	2084	1	ATP2A2	12	110778732	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	13620800	110778732	23073163	338	26006										
ARPC3	10094	broad.mit.edu	37	chr12	110874486	110874486	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcaccttggcttttggaattGcactggaaaaaaaaatatat	7	6	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:110874486G>A	uc001tqq.2	-	5	348	c.255C>T	c.(253-255)TGC>TGT	p.C85C		NM_005719	NP_005710	O15145	ARPC3_HUMAN	actin related protein 2/3 complex subunit 3	85					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			ovary(1)	1						TTTTGGAATTGCACTGGaaaa	0.254													0	0	0	0.00308	0	7	27										A	110874486	G	A	110874486	2	1	87	1	0	0	0	0	0	0	0	1	972	1311	46	2		2	ARPC3	12	110874486	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	95754	110874486	22977409	339	26007										
DDX54	79039	broad.mit.edu	37	chr12	113599123	113599123	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcgctctgggcctcgccggtCagatgccccttcttcgtccg	11	17	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:113599123C>A	uc001tup.2	-	19	2393	c.2365G>T	c.(2365-2367)GAC>TAC	p.D789Y	DDX54_uc001tuq.3_Missense_Mutation_p.D789Y	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	789					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						CCTCGCCGGTCAGATGCCCCT	0.577													1	0	9.16793e-09	0.00499	9.64887e-09	15	37										A	113599123	C	A	113599123	3	1	87	1	0	0	0	0	1	0	0	0	4372	826	29	3	291	3	DDX54	12	113599123	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2724637	113599123	20252772	340	26008										
HIP1R	9026	broad.mit.edu	37	chr12	123345546	123345546	+	Frame_Shift_Del	DEL	G	G	-													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagagggctgccaatgtggtGgcctccaccaagtcaggcca							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:123345546delG	uc001udj.1	+	29	2909	c.2850delG	c.(2848-2850)GTGfs	p.V950fs	HIP1R_uc001udk.1_Frame_Shift_Del_p.V215fs	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	950	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCAATGTGGTGGCCTCCACCA	0.637																		20	18	---	---								-	123345546	G	-	123345546	7	5	87	1	0	1	0	1	0	0	0	0	7115	1335	47	0	2964	0	HIP1R	12	123345546	Frame_Shift_Del	DEL	G	TCGA-FD-A3SS-01A-12D-A22Z-08	9746423	123345546	10506349	341	26009										
EP400	57634	broad.mit.edu	37	chr12	132445298	132445298	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgcagctcccttcgctccctCagcaagcccgtcggcacccc	8	22	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:132445298C>T	uc001ujn.2	+	1	169	c.134C>T	c.(133-135)TCA>TTA	p.S45L	EP400_uc001ujl.2_Missense_Mutation_p.S45L|EP400_uc001ujm.2_Missense_Mutation_p.S45L|EP400_uc001ujj.1_Missense_Mutation_p.S45L|EP400_uc001ujk.2_Missense_Mutation_p.S45L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	45					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTCGCTCCCTCAGCAAGCCCG	0.652													0	0	0	0.004007	0	16	12										T	132445298	C	T	132445298	3	4	87	1	0	0	0	0	1	0	0	0	5149	838	29	1	136	1	EP400	12	132445298	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9099752	132445298	1406597	342	26010										
ZNF10	7556	broad.mit.edu	37	chr12	133732614	133732614	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tatatcaaagggcatacataGagagaaaccctatgaatgta	8	6	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:133732614G>C	uc009zzb.2	+	5	1229	c.782G>C	c.(781-783)AGA>ACA	p.R261T	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.R261T	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	261				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GGCATACATAGAGAGAAACCC	0.393													0	0	0	0.013537	0	12	51										C	133732614	G	C	133732614	3	2	87	1	0	0	0	0	1	0	0	0	17709	942	33	1	796	1	ZNF10	12	133732614	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1287316	133732614	119281	343	26011										
TPTE2	93492	broad.mit.edu	37	chr13	20039688	20039688	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aataataagtcgtagaagtcGaactaaatgtgtccatctaa	7	6	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:20039688G>A	uc001umd.2	-	9	740	c.529C>T	c.(529-531)CGA>TGA	p.R177*	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Nonsense_Mutation_p.R66*|TPTE2_uc001ume.2_Nonsense_Mutation_p.R100*|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTAGAAGTCGAACTAAATGT	0.289													0	0	0	0.00499	0	17	22										A	20039688	G	A	20039688	4	1	87	1	0	0	0	0	0	1	0	0	16428	1066	37	1	1091	1	TPTE2	13	20039688	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		20039688	95130190	344	26012										
SACS	26278	broad.mit.edu	37	chr13	23915245	23915246	+	In_Frame_Ins	INS	-	-	TTC													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgcgcttgaatattgccaaINSttcttgaataattcttttct							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:23915245_23915246insTTC	uc001uon.2	-	10	3358_3359	c.2769_2770insGAA	c.(2767-2772)insGAA	p.923_924insE	SACS_uc001uoo.2_In_Frame_Ins_p.776_777insE|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	923_924					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATATTGCCAATTCTTGAATAA	0.376																		41	98	---	---								TTC	23915246	-	TTC	23915245	7	5	87	1	0	1	1	0	0	0	0	0	13804	98	4	0	10973	0	SACS	13	23915245	In_Frame_Ins	INS	-	TCGA-FD-A3SS-01A-12D-A22Z-08	3875557	23915245	91254633	345	26013										
ATP12A	479	broad.mit.edu	37	chr13	25283562	25283562	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acatcatgaacaggaagcctCgccacaagaataaggacagg	10	10	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:25283562C>T	uc001upp.2	+	18	2741	c.2554C>T	c.(2554-2556)CGC>TGC	p.R852C	ATP12A_uc010aaa.2_Missense_Mutation_p.R858C	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	852	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CAGGAAGCCTCGCCACAAGAA	0.557													0	0	0	0.001855	0	12	58										T	25283562	C	T	25283562	3	4	87	1	0	0	0	0	1	0	0	0	1122	884	31	1	2642	1	ATP12A	13	25283562	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1368317	25283562	89886316	346	26014										
BRCA2	675	broad.mit.edu	37	chr13	32915264	32915264	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	attctctttttacatgtcccGaaaatgaggaaatggttttg	8	6	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:32915264G>A	uc001uub.1	+	11	6999	c.6772G>A	c.(6772-6774)GAA>AAA	p.E2258K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2258					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TACATGTCCCGAAAATGAGGA	0.378			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00499	0	18	179										A	32915264	G	A	32915264	3	1	87	1	0	0	0	0	1	0	0	0	1499	1059	37	1	6810	1	BRCA2	13	32915264	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	7631702	32915264	82254614	347	26015										
COG3	83548	broad.mit.edu	37	chr13	46103990	46103990	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acaaagctgcctgtgacattGagaagtatgtccttgtacct	9	9	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:46103990G>A	uc001vak.2	+	21	2396	c.2295G>A	c.(2293-2295)TTG>TTA	p.L765L	COG3_uc010tfv.1_Silent_p.L602L|COG3_uc010aci.2_Silent_p.L541L	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	765					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CTGTGACATTGAGAAGTATGT	0.388													0	0	0	0.006999	0	38	25										A	46103990	G	A	46103990	2	1	87	1	0	0	0	0	0	0	0	1	3659	1281	45	1		1	COG3	13	46103990	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	13188726	46103990	69065888	348	26016										
UTP14C	9724	broad.mit.edu	37	chr13	52605165	52605165	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtgggctaccagtcttcctCaaggtcagacctgcctgtca	10	13	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:52605165C>T	uc001vgb.2	+	2	2760	c.2225C>T	c.(2224-2226)TCA>TTA	p.S742L	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	742					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CAGTCTTCCTCAAGGTCAGAC	0.478													0	0	0	0.004007	0	15	143										T	52605165	C	T	52605165	3	4	87	1	0	0	0	0	1	0	0	0	17093	838	29	1	2227	1	UTP14C	13	52605165	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6501175	52605165	62564713	349	26017										
KLF5	688	broad.mit.edu	37	chr13	73649905	73649905	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggaggttcgcgcgatcggatGagctgacccgccactaccgg	15	13	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:73649905G>A	uc001vje.2	+	4	1579	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K	KLF5_uc001vjd.2_Missense_Mutation_p.E328K	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	419	C2H2-type 2.				transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GCGATCGGATGAGCTGACCCG	0.592													0	0	0	0.00308	0	7	54										A	73649905	G	A	73649905	3	1	87	1	0	0	0	0	1	0	0	0	8349	1291	45	1	1269	1	KLF5	13	73649905	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	21044740	73649905	41519973	350	26018										
GRTP1	79774	broad.mit.edu	37	chr13	114009747	114009747	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gccccactcagcaccatccaGacgcgggcacggtgctccag	11	18	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114009747G>T	uc001vtn.2	-	3	328	c.231C>A	c.(229-231)GTC>GTA	p.V77V	GRTP1_uc010tkb.1_Translation_Start_Site|GRTP1_uc010tkc.1_Silent_p.V77V|GRTP1_uc010agv.1_RNA	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	77	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GCACCATCCAGACGCGGGCAC	0.662													1	0	4.96729e-08	0.008871	5.19381e-08	21	27										T	114009747	G	T	114009747	2	4	87	1	0	0	0	0	0	0	0	1	6810	929	33	3		3	GRTP1	13	114009747	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	40359842	114009747	1160131	351	26019										
ADPRHL1	113622	broad.mit.edu	37	chr13	114077230	114077230	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tggtacaagcctttgggaacGaggtccaggccgtacagcaa	13	10	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114077230G>A	uc001vtq.1	-	7	1059	c.972C>T	c.(970-972)CTC>CTT	p.L324L	ADPRHL1_uc001vtp.1_Silent_p.L242L	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	324					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTTTGGGAACGAGGTCCAGGC	0.617													0	0	0	0.001984	0	6	83										A	114077230	G	A	114077230	2	1	87	1	0	0	0	0	0	0	0	1	332	1045	37	1		1	ADPRHL1	13	114077230	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	67483	114077230	1092648	352	26020										
TMCO3	55002	broad.mit.edu	37	chr13	114150069	114150069	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggacagctgcaggaagctctCagggcttctccgccagaaga	13	12	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114150069C>T	uc001vtu.3	+	2	534	c.173C>T	c.(172-174)TCA>TTA	p.S58L	TMCO3_uc001vtt.3_Missense_Mutation_p.S58L	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	58						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			AGGAAGCTCTCAGGGCTTCTC	0.582													0	0	0	0.010729	0	12	18										T	114150069	C	T	114150069	3	4	87	1	0	0	0	0	1	0	0	0	15994	838	29	1	175	1	TMCO3	13	114150069	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	72839	114150069	1019809	353	26021										
ZNF828	283489	broad.mit.edu	37	chr13	115090645	115090645	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccagagctcagaaaaccctCagggtcaccagatctttgga	9	12	4	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:115090645C>T	uc010ahb.2	+	3	1657	c.1328C>T	c.(1327-1329)TCA>TTA	p.S443L	ZNF828_uc001vuv.2_Missense_Mutation_p.S443L|ZNF828_uc010tko.1_Missense_Mutation_p.S443L	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	443	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		AGAAAACCCTCAGGGTCACCA	0.537													0	0	0	0.01441	0	72	151										T	115090645	C	T	115090645	3	4	87	1	0	0	0	0	1	0	0	0	18178	838	29	1	1330	1	ZNF828	13	115090645	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	940576	115090645	79233	354	26022										
JUB	84962	broad.mit.edu	37	chr14	23445703	23445703	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	accacagacacagcatttctCagctgcctcctgaaaccctg	6	16	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23445703C>G	uc001whz.2	-	4	1577	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q	JUB_uc001why.2_5'UTR	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	401	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CAGCATTTCTCAGCTGCCTCC	0.478													0	0	0	0.01441	0	49	188										G	23445703	C	G	23445703	3	3	87	1	0	0	0	0	1	0	0	0	7968	835	29	1	435	1	JUB	14	23445703	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		23445703	83903837	355	26023										
C14orf93	60686	broad.mit.edu	37	chr14	23456450	23456450	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atccttttccaccttgatttCaatgaatgagttcaagtcag	6	9	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23456450C>G	uc001wib.1	-	7	1901	c.1591G>C	c.(1591-1593)GAA>CAA	p.E531Q	C14orf93_uc001wic.1_Missense_Mutation_p.E351Q|C14orf93_uc001wid.1_Missense_Mutation_p.E531Q|C14orf93_uc001wig.2_Missense_Mutation_p.E531Q|C14orf93_uc001wih.2_Missense_Mutation_p.E531Q|C14orf93_uc001wie.2_Missense_Mutation_p.E531Q|C14orf93_uc001wia.3_Missense_Mutation_p.E491Q|C14orf93_uc001wif.2_Missense_Mutation_p.E351Q	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	531						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		ACCTTGATTTCAATGAATGAG	0.483											OREG0022593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	35										G	23456450	C	G	23456450	3	3	87	1	0	0	0	0	1	0	0	0	1782	835	29	1	29	1	C14orf93	14	23456450	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10747	23456450	83893090	356	26024										
PABPN1	8106	broad.mit.edu	37	chr14	23792641	23792641	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcactttcatggctgtggttCagtcaaccgtgttaccatac	8	11	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23792641C>T	uc001wjk.2	+	4	1872	c.590C>T	c.(589-591)TCA>TTA	p.S197L	PABPN1_uc001wjh.3_Missense_Mutation_p.S224L|PABPN1_uc001wjj.2_Missense_Mutation_p.S197L	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	197	Necessary for homooligomerization.|RRM.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GGCTGTGGTTCAGTCAACCGT	0.428													0	0	0	0.010729	0	9	78										T	23792641	C	T	23792641	3	4	87	1	0	0	0	0	1	0	0	0	11368	838	29	1	604	1	PABPN1	14	23792641	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	336191	23792641	83556899	357	26025										
ADCY4	196883	broad.mit.edu	37	chr14	24799114	24799114	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tagccagtgtgacatcatgtGaccaaacgtcgtactgccac	9	12	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:24799114G>A	uc001wov.2	-	8	1175	c.1169C>T	c.(1168-1170)TCA>TTA	p.S390L	ADCY4_uc001wow.2_Missense_Mutation_p.S390L|ADCY4_uc010toh.1_Missense_Mutation_p.S76L|ADCY4_uc001wox.2_Missense_Mutation_p.S390L|ADCY4_uc001woy.2_Missense_Mutation_p.S390L	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	390	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GACATCATGTGACCAAACGTC	0.597													0	0	0	0.010504	0	20	112										A	24799114	G	A	24799114	3	1	87	1	0	0	0	0	1	0	0	0	296	1294	45	1	2136	1	ADCY4	14	24799114	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1006473	24799114	82550426	358	26026										
G2E3	55632	broad.mit.edu	37	chr14	31074728	31074728	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	taggcaaggcagcaaatttaGaagaaatgtatcaacactat	8	6	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:31074728G>C	uc001wqk.2	+	11	1182	c.1028G>C	c.(1027-1029)AGA>ACA	p.R343T	G2E3_uc010tpe.1_Intron|G2E3_uc010tpf.1_Missense_Mutation_p.R297T	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	343					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGCAAATTTAGAAGAAATGTA	0.269													0	0	0	0.00308	0	8	28										C	31074728	G	C	31074728	3	2	87	1	0	0	0	0	1	0	0	0	6140	942	33	1	1066	1	G2E3	14	31074728	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6275614	31074728	76274812	359	26027										
NID2	22795	broad.mit.edu	37	chr14	52520475	52520475	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggtagggctggatgcttccGttttcggggtacggtggtgg	20	6	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:52520475G>T	uc001wzo.2	-	5	1485	c.1251C>A	c.(1249-1251)AAC>AAA	p.N417K	NID2_uc010tqs.1_Missense_Mutation_p.N417K|NID2_uc010tqt.1_Missense_Mutation_p.N417K|NID2_uc001wzp.2_Missense_Mutation_p.N417K	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	417						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GGATGCTTCCGTTTTCGGGGT	0.557													1	0	1.5548e-18	0.005443	1.69471e-18	26	83										T	52520475	G	T	52520475	3	4	87	1	0	0	0	0	1	0	0	0	10415	1136	40	4	2948	4	NID2	14	52520475	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	21445747	52520475	54829065	360	26028										
SAMD4A	23034	broad.mit.edu	37	chr14	55169071	55169071	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagctttggtggccagaaccGaggccgctcagactctgtgg	14	12	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:55169071G>A	uc001xbb.2	+	2	486	c.485G>A	c.(484-486)CGA>CAA	p.R162Q	SAMD4A_uc001xba.2_Missense_Mutation_p.R162Q|SAMD4A_uc001xbc.2_Missense_Mutation_p.R162Q|SAMD4A_uc001xbf.1_RNA|SAMD4A_uc001xbe.2_Missense_Mutation_p.R62Q	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	163					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						GGCCAGAACCGAGGCCGCTCA	0.512													0	0	0	0.00632	0	27	61										A	55169071	G	A	55169071	3	1	87	1	0	0	0	0	1	0	0	0	13821	1058	37	1	491	1	SAMD4A	14	55169071	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2648596	55169071	52180469	361	26029										
DLGAP5	9787	broad.mit.edu	37	chr14	55618550	55618550	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttccacaacatctgaaattCcttcttttttgttagtatta	3	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:55618550C>G	uc001xbs.2	-	17	2448	c.2231G>C	c.(2230-2232)GGA>GCA	p.G744A	DLGAP5_uc001xbt.2_Missense_Mutation_p.G744A	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	744					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						ATCTGAAATTCCTTCTTTTTT	0.368													0	0	0	0.003163	0	16	67										G	55618550	C	G	55618550	3	3	87	1	0	0	0	0	1	0	0	0	4563	855	30	1	416	1	DLGAP5	14	55618550	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	449479	55618550	51730990	362	26030										
C14orf37	145407	broad.mit.edu	37	chr14	58604778	58604778	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acagaaacagtggtttctaaGaaaaacagggcatcgttttc	9	7	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:58604778G>C	uc001xdc.2	-	2	1410	c.1299C>G	c.(1297-1299)TTC>TTG	p.F433L	C14orf37_uc010tro.1_Missense_Mutation_p.F471L|C14orf37_uc001xdd.2_Missense_Mutation_p.F433L|C14orf37_uc001xde.2_Missense_Mutation_p.F433L	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	433	Extracellular (Potential).					integral to membrane	binding				0						TGGTTTCTAAGAAAAACAGGG	0.398													0	0	0	0.00245	0	13	93										C	58604778	G	C	58604778	3	2	87	1	0	0	0	0	1	0	0	0	1771	933	33	1	1053	1	C14orf37	14	58604778	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2986228	58604778	48744762	363	26031										
C14orf37	145407	broad.mit.edu	37	chr14	58604814	58604814	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttttccttggtggattccgtGaagtctcccgtactttggag	11	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:58604814G>A	uc001xdc.2	-	2	1374	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	C14orf37_uc010tro.1_Silent_p.F459F|C14orf37_uc001xdd.2_Silent_p.F421F|C14orf37_uc001xde.2_Silent_p.F421F	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	421	Extracellular (Potential).					integral to membrane	binding				0						TGGATTCCGTGAAGTCTCCCG	0.438													0	0	0	0.013537	0	12	75										A	58604814	G	A	58604814	2	1	87	1	0	0	0	0	0	0	0	1	1771	1281	45	1		1	C14orf37	14	58604814	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	36	58604814	48744726	364	26032										
PLEKHG3	26030	broad.mit.edu	37	chr14	65198192	65198192	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgcaatgaaaggacctttttCctctttgacaaaacactgct	6	11	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:65198192C>T	uc001xho.1	+	8	1232	c.963C>T	c.(961-963)TTC>TTT	p.F321F	PLEKHG3_uc001xhn.1_Silent_p.F265F|PLEKHG3_uc001xhp.2_Silent_p.F321F|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	321	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGACCTTTTTCCTCTTTGACA	0.567													0	0	0	0.005443	0	26	55										T	65198192	C	T	65198192	2	4	87	1	0	0	0	0	0	0	0	1	12070	854	30	1		1	PLEKHG3	14	65198192	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6593378	65198192	42151348	365	26033										
VIPAR	63894	broad.mit.edu	37	chr14	77916080	77916080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagaaagggactggaaacttCcaggtctagttctacctaaa	9	9	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:77916080C>T	uc001xtt.1	-	6	697	c.359G>A	c.(358-360)GGA>GAA	p.G120E	VIPAR_uc001xtu.1_Missense_Mutation_p.G120E|VIPAR_uc010tvj.1_Missense_Mutation_p.G71E|VIPAR_uc001xtv.1_Missense_Mutation_p.G120E	NM_022067	NP_071350	Q9H9C1	VIPAR_HUMAN	hypothetical protein LOC63894	120					endosome to lysosome transport|intracellular protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	early endosome|late endosome|recycling endosome	protein binding			central_nervous_system(1)	1						CTGGAAACTTCCAGGTCTAGT	0.443													0	0	0	0.010771	0	44	72										T	77916080	C	T	77916080	3	4	87	1	0	0	0	0	1	0	0	0	17165	855	30	1	1186	1	VIPAR	14	77916080	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	12717888	77916080	29433460	366	26034										
NRXN3	9369	broad.mit.edu	37	chr14	79269994	79269994	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgagctatgatggtagcatGtacatgaagatcatcatgcc	10	8	2	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:79269994G>C	uc001xun.2	+	6	1448	c.957G>C	c.(955-957)ATG>ATC	p.M319I	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.M453I	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	692	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ATGGTAGCATGTACATGAAGA	0.498													0	0	0	0.01441	0	49	75										C	79269994	G	C	79269994	3	2	87	1	0	0	0	0	1	0	0	0	10667	1377	48	4	971	4	NRXN3	14	79269994	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1353914	79269994	28079546	367	26035										
GALC	2581	broad.mit.edu	37	chr14	88450815	88450815	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gacataataggcagtcagctGaagattgacataaggccagt	11	7	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:88450815G>A	uc001xvt.2	-	5	904	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	GALC_uc010tvx.1_Nonsense_Mutation_p.Q143*|GALC_uc010tvy.1_Nonsense_Mutation_p.Q146*|GALC_uc010tvz.1_Nonsense_Mutation_p.Q113*|GALC_uc001xvu.1_Nonsense_Mutation_p.Q169*	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	169					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						GCAGTCAGCTGAAGATTGACA	0.453													0	0	0	0.008871	0	18	32										A	88450815	G	A	88450815	4	1	87	1	0	0	0	0	0	1	0	0	6201	1299	45	1	1667	1	GALC	14	88450815	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	9180821	88450815	18898725	368	26036										
ZC3H14	79882	broad.mit.edu	37	chr14	89034385	89034385	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acctttccttttaaatagatGaagaacttcctgattacatt	4	8	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:89034385G>A	uc001xww.2	+	3	307	c.82G>A	c.(82-84)GAA>AAA	p.E28K	ZC3H14_uc010twd.1_Missense_Mutation_p.E28K|ZC3H14_uc010twe.1_Missense_Mutation_p.E28K|ZC3H14_uc001xwx.2_Missense_Mutation_p.E28K|ZC3H14_uc010twf.1_5'UTR|ZC3H14_uc001xwy.2_5'UTR	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	28						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTAAATAGATGAAGAACTTCC	0.363													0	0	0	0.00308	0	8	36										A	89034385	G	A	89034385	3	1	87	1	0	0	0	0	1	0	0	0	17563	1291	45	1	92	1	ZC3H14	14	89034385	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	583570	89034385	18315155	369	26037										
C14orf143	90141	broad.mit.edu	37	chr14	90416473	90416473	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gatttattgaagacatcacaGaatccacttctatctagaaa	5	8	3	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:90416473G>A	uc001xxt.2	-	3	270	c.185C>T	c.(184-186)TCT>TTT	p.S62F	C14orf143_uc001xxs.2_Missense_Mutation_p.S38F|C14orf143_uc001xxv.1_RNA|C14orf143_uc001xxw.1_Missense_Mutation_p.S38F|C14orf143_uc001xxx.1_Missense_Mutation_p.S62F	NM_145231	NP_660274	Q9BUY7	EFC11_HUMAN	hypothetical protein LOC90141	62							calcium ion binding				0		all_cancers(154;0.136)		Epithelial(152;0.194)		AGACATCACAGAATCCACTTC	0.254													0	0	0	0.00308	0	6	14										A	90416473	G	A	90416473	3	1	87	1	0	0	0	0	1	0	0	0	1748	942	33	1	322	1	C14orf143	14	90416473	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1382088	90416473	16933067	370	26038										
PSMC1	5700	broad.mit.edu	37	chr14	90735763	90735763	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgactccaattctggtggtGagagagaaattcagcgaaca	11	7	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:90735763G>C	uc001xyf.2	+	9	952	c.904G>C	c.(904-906)GAG>CAG	p.E302Q	PSMC1_uc001xyg.2_Missense_Mutation_p.E229Q|PSMC1_uc001xyh.2_Missense_Mutation_p.E229Q	NM_002802	NP_002793	P62191	PRS4_HUMAN	proteasome 26S ATPase subunit 1	302					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		TTCTGGTGGTGAGAGAGAAAT	0.418													0	0	0	0.001855	0	13	77										C	90735763	G	C	90735763	3	2	87	1	0	0	0	0	1	0	0	0	12685	1291	45	1	938	1	PSMC1	14	90735763	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	319290	90735763	16613777	371	26039										
RAGE	5891	broad.mit.edu	37	chr14	102749865	102749865	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcatagtagtttccatctctCaggctttgcatcttcataac	6	11	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102749865C>G	uc001ylm.2	-	2	298	c.72G>C	c.(70-72)CTG>CTC	p.L24L	RAGE_uc010txv.1_Silent_p.L24L|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	24	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TTCCATCTCTCAGGCTTTGCA	0.358													0	0	0	0.009535	0	28	42										G	102749865	C	G	102749865	2	3	87	1	0	0	0	0	0	0	0	1	13006	813	29	1		1	RAGE	14	102749865	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	12014102	102749865	4599675	372	26040										
CINP	51550	broad.mit.edu	37	chr14	102822155	102822155	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acacagcttctccagttcctCgttatattccagacacacct	4	15	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102822155C>T	uc001ylv.1	-	3	321	c.256G>A	c.(256-258)GAG>AAG	p.E86K	CINP_uc001ylu.1_RNA	NM_032630	NP_116019	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2-interacting protein	86	Potential.				cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(1)	1						TCCAGTTCCTCGTTATATTCC	0.443													0	0	0	0.004007	0	16	74										T	102822155	C	T	102822155	3	4	87	1	0	0	0	0	1	0	0	0	3431	893	31	1	394	1	CINP	14	102822155	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	72290	102822155	4527385	373	26041										
AKT1	207	broad.mit.edu	37	chr14	105243078	105243078	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gatgatgaaggtgttgggccGgggccgctccgtcttcatca	15	10	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105243078G>T	uc001ypk.2	-	4	759	c.205C>A	c.(205-207)CGG>AGG	p.R69R	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.R69R|AKT1_uc010axa.2_Silent_p.R69R|AKT1_uc001ypm.2_Silent_p.R69R|AKT1_uc001ypn.2_Silent_p.R69R|AKT1_uc010tyk.1_Silent_p.R7R	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	69	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	GTGTTGGGCCGGGGCCGCTCC	0.672		1	Mis		breast|colorectal|ovarian|NSCLC								1	0	6.72482e-11	0.003163	7.17166e-11	14	35										T	105243078	G	T	105243078	2	4	87	1	0	0	0	0	0	0	0	1	478	1115	39	4		4	AKT1	14	105243078	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2420923	105243078	2106462	374	26042										
AHNAK2	113146	broad.mit.edu	37	chr14	105406884	105406884	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acctttggccctgtttccttCttcggggaccacctaaatga	8	13	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105406884C>T	uc010axc.1	-	7	15024	c.14904G>A	c.(14902-14904)AAG>AAA	p.K4968K	AHNAK2_uc001ypx.2_Silent_p.K4868K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4968						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGTTTCCTTCTTCGGGGACC	0.532													0	0	0	0.00245	0	13	23										T	105406884	C	T	105406884	2	4	87	1	0	0	0	0	0	0	0	1	415	912	32	1		1	AHNAK2	14	105406884	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	163806	105406884	1942656	375	26043										
AHNAK2	113146	broad.mit.edu	37	chr14	105413428	105413428	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcgcaccatccagctttgctCtcggggcctggacgtccacc	11	17	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105413428C>G	uc010axc.1	-	7	8480	c.8360G>C	c.(8359-8361)AGA>ACA	p.R2787T	AHNAK2_uc001ypx.2_Missense_Mutation_p.R2687T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2787						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGCTTTGCTCTCGGGGCCTG	0.602													0	0	0	0.01441	0	119	221										G	105413428	C	G	105413428	3	3	87	1	0	0	0	0	1	0	0	0	415	913	32	1	9031	1	AHNAK2	14	105413428	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6544	105413428	1936112	376	26044										
GABRB3	2562	broad.mit.edu	37	chr15	26793038	26793038	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tatggcattcacatcggttaGatcaggtattttaattttga	8	5	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:26793038G>C	uc001zaz.2	-	9	1466	c.1324C>G	c.(1324-1326)CTA>GTA	p.L442V	GABRB3_uc010uae.1_Missense_Mutation_p.L357V|GABRB3_uc001zba.2_Missense_Mutation_p.L442V|GABRB3_uc001zbb.2_Missense_Mutation_p.L498V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	442	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACATCGGTTAGATCAGGTATT	0.458													0	0	0	0.003271	0	33	38										C	26793038	G	C	26793038	3	2	87	1	0	0	0	0	1	0	0	0	6168	933	33	1	101	1	GABRB3	15	26793038	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		26793038	75738354	377	26045										
GABRA5	2558	broad.mit.edu	37	chr15	27193135	27193135	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acgcttttacaactgggaagAtgtctcaccccccaaacatt	6	13	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:27193135A>G	uc001zbd.1	+	12	1483	c.1144A>G	c.(1144-1146)ATG>GTG	p.M382V	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	382	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACTGGGAAGATGTCTCACCC	0.433													0	0	0	0.000602	0	4	5										G	27193135	A	G	27193135	3	3	87	1	0	0	0	0	1	0	0	0	6164	333	12	5	1178	5	GABRA5	15	27193135	Missense_Mutation	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	400097	27193135	75338257	378	26046										
AVEN	57099	broad.mit.edu	37	chr15	34159807	34159807	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcatctaaattaagcaacaGatctagttcttcttccaaat	4	9	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:34159807G>A	uc001zhj.2	-	5	918	c.862C>T	c.(862-864)CTG>TTG	p.L288L		NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	288					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		TTAAGCAACAGATCTAGTTCT	0.488													0	0	0	0.010818	0	32	147										A	34159807	G	A	34159807	2	1	87	1	0	0	0	0	0	0	0	1	1226	933	33	1		1	AVEN	15	34159807	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6966672	34159807	68371585	379	26047										
DLL4	54567	broad.mit.edu	37	chr15	41228778	41228778	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccagcttcccctgggtggcCgtctcgctgggtgtggggct	16	14	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:41228778C>T	uc001zng.1	+	9	1913	c.1593C>T	c.(1591-1593)GCC>GCT	p.A531A		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	531	Helical; (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CCTGGGTGGCCGTCTCGCTGG	0.672													0	0	0	0.00308	0	8	10										T	41228778	C	T	41228778	2	4	87	1	0	0	0	0	0	0	0	1	4568	639	23	2		2	DLL4	15	41228778	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	7068971	41228778	61302614	380	26048										
TTBK2	146057	broad.mit.edu	37	chr15	43044650	43044650	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaaggatgacctaaccatatCcttccgggttggggcaccat	10	11	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:43044650C>T	uc001zqo.2	-	14	3233	c.2794G>A	c.(2794-2796)GAT>AAT	p.D932N	TTBK2_uc010bcy.2_Missense_Mutation_p.D863N	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	932					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTAACCATATCCTTCCGGGTT	0.428													0	0	0	0.003271	0	34	79										T	43044650	C	T	43044650	3	4	87	1	0	0	0	0	1	0	0	0	16674	855	30	1	948	1	TTBK2	15	43044650	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1815872	43044650	59486742	381	26049										
ALDH1A2	8854	broad.mit.edu	37	chr15	58256149	58256149	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgcctcttggcccgctccacGcttcttctcacaaactcctc	5	20	3	0	rs114347273	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:58256149G>A	uc002aex.2	-	9	1078	c.1020C>T	c.(1018-1020)AGC>AGT	p.S340S	ALDH1A2_uc002aey.2_Silent_p.S302S|ALDH1A2_uc010ugv.1_Silent_p.S319S|ALDH1A2_uc010ugw.1_Silent_p.S311S|ALDH1A2_uc002aew.2_Silent_p.S244S	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	340					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CCCGCTCCACGCTTCTTCTCA	0.542													0	0	0	0.00632	0	26	84										A	58256149	G	A	58256149	2	1	87	1	0	0	0	0	0	0	0	1	491	1078	38	2		2	ALDH1A2	15	58256149	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	15211499	58256149	44275243	382	26050										
CELF6	60677	broad.mit.edu	37	chr15	72581516	72581516	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccgttattgtagagcgtgtcGgagcccggctggccattggt	15	10	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:72581516G>A	uc002auh.2	-	8	1303	c.993C>T	c.(991-993)TCC>TCT	p.S331S	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010biw.2_Silent_p.S218S|CELF6_uc010ukl.1_Silent_p.S215S|CELF6_uc010ukm.1_Silent_p.S331S|CELF6_uc002aui.2_Silent_p.S437S|CELF6_uc002auj.2_Silent_p.S218S	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	331					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						AGAGCGTGTCGGAGCCCGGCT	0.692													0	0	0	0.004672	0	3	5										A	72581516	G	A	72581516	2	1	87	1	0	0	0	0	0	0	0	1	3220	1103	39	2		2	CELF6	15	72581516	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	14325367	72581516	29949876	383	26051										
LOXL1	4016	broad.mit.edu	37	chr15	74240184	74240184	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctatgacacctacaatgcgGacatcgactgccagtggatc	10	12	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:74240184G>A	uc002awc.1	+	5	1879	c.1543G>A	c.(1543-1545)GAC>AAC	p.D515N	LOXL1_uc002awd.1_RNA	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	515	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						CTACAATGCGGACATCGACTG	0.597													0	0	0	0.013537	0	10	96										A	74240184	G	A	74240184	3	1	87	1	0	0	0	0	1	0	0	0	8899	1174	41	1	1561	1	LOXL1	15	74240184	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1658668	74240184	28291208	384	26052										
SCAPER	49855	broad.mit.edu	37	chr15	76673758	76673758	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agagctgcaaagctgttgaaGaaacgtaaactctgaatggc	11	7	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:76673758G>T	uc002bby.2	-	27	3725	c.3666C>A	c.(3664-3666)TTC>TTA	p.F1222L	SCAPER_uc010bkr.2_Missense_Mutation_p.F530L|SCAPER_uc002bbx.2_Missense_Mutation_p.F976L|SCAPER_uc002bbz.1_Missense_Mutation_p.F1093L	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1221						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AGCTGTTGAAGAAACGTAAAC	0.428													1	0	2.17888e-05	0.006214	2.24894e-05	8	34										T	76673758	G	T	76673758	3	4	87	1	0	0	0	0	1	0	0	0	13878	933	33	3	556	3	SCAPER	15	76673758	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2433574	76673758	25857634	385	26053										
SCAPER	49855	broad.mit.edu	37	chr15	76673922	76673922	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agcagctgtcagccctgtggGatcctggcgattattgtcaa	12	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:76673922G>A	uc002bby.2	-	27	3561	c.3502C>T	c.(3502-3504)CCC>TCC	p.P1168S	SCAPER_uc010bkr.2_Missense_Mutation_p.P476S|SCAPER_uc002bbx.2_Missense_Mutation_p.P922S|SCAPER_uc002bbz.1_Missense_Mutation_p.P1039S	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1167						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AGCCCTGTGGGATCCTGGCGA	0.453													0	0	0	0.009096	0	4	13										A	76673922	G	A	76673922	3	1	87	1	0	0	0	0	1	0	0	0	13878	1174	41	1	720	1	SCAPER	15	76673922	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	164	76673922	25857470	386	26054										
CPEB1	64506	broad.mit.edu	37	chr15	83295967	83295967	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcaaatgatcatgaattcctCggtttataggtgtagtgcag	11	6	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:83295967C>T	uc002bit.2	-	2	484	c.347G>A	c.(346-348)CGA>CAA	p.R116Q	CPEB1_uc002biu.2_Missense_Mutation_p.R83Q|CPEB1_uc010uof.1_5'UTR|CPEB1_uc002biv.2_Missense_Mutation_p.R56Q	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	56					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			ATGAATTCCTCGGTTTATAGG	0.403													0	0	0	0.004656	0	25	76										T	83295967	C	T	83295967	3	4	87	1	0	0	0	0	1	0	0	0	3800	884	31	1	1577	1	CPEB1	15	83295967	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6622045	83295967	19235425	387	26055										
SV2B	9899	broad.mit.edu	37	chr15	91809817	91809817	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atttttacttttcaggtttcCaacatcaaaactcccaagca	3	11	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:91809817C>G	uc002bqv.2	+	6	1405	c.1014C>G	c.(1012-1014)TCC>TCG	p.S338S	SV2B_uc002bqt.2_Silent_p.S338S|SV2B_uc010uqv.1_Silent_p.S187S|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	338	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTCAGGTTTCCAACATCAAAA	0.368													0	0	0	0.003163	0	14	41										G	91809817	C	G	91809817	2	3	87	1	0	0	0	0	0	0	0	1	15415	581	21	4		4	SV2B	15	91809817	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	8513850	91809817	10721575	388	26056										
LUC7L	55692	broad.mit.edu	37	chr16	270656	270656	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aataaaacttacatctaattCaaaaaacaggtctctttctt	2	8	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:270656C>G	uc002cgc.1	-	3	358	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	LUC7L_uc002cga.1_Missense_Mutation_p.E83Q|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Missense_Mutation_p.E83Q	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	83							metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				ACATCTAATTCAAAAAACAGG	0.308													0	0	0	0.01441	0	60	98										G	270656	C	G	270656	3	3	87	1	0	0	0	0	1	0	0	0	9082	835	29	1	904	1	LUC7L	16	270656	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		270656	90084097	389	26057										
NARFL	64428	broad.mit.edu	37	chr16	783368	783368	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagtcgggtctggaggcttcCagctttttgtcatagcaggg	14	8	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:783368C>A	uc002cjr.2	-	7	765	c.753G>T	c.(751-753)CTG>CTT	p.L251L	NARFL_uc002cjp.2_Silent_p.L149L|NARFL_uc002cjq.2_Silent_p.L149L|NARFL_uc002cjs.2_Silent_p.L33L|NARFL_uc010uuq.1_5'Flank	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	251					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				TGGAGGCTTCCAGCTTTTTGT	0.557													1	0	0.00024832	0.009096	0.000253452	4	51										A	783368	C	A	783368	2	1	87	1	0	0	0	0	0	0	0	1	10168	581	21	4		4	NARFL	16	783368	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	512712	783368	89571385	390	26058										
IFT140	9742	broad.mit.edu	37	chr16	1618267	1618267	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgctgctgctgcaccgcagaGaagcgatgccccccacccca	10	19	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:1618267G>A	uc002cmb.2	-	15	2083	c.1721C>T	c.(1720-1722)TCT>TTT	p.S574F	IFT140_uc002clz.2_Missense_Mutation_p.S225F	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	574										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GCACCGCAGAGAAGCGATGCC	0.672													0	0	0	0.00308	0	6	18										A	1618267	G	A	1618267	3	1	87	1	0	0	0	0	1	0	0	0	7556	942	33	1	2735	1	IFT140	16	1618267	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	834899	1618267	88736486	391	26059										
SRRM2	23524	broad.mit.edu	37	chr16	2817596	2817596	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtgaatattgccggctccaGaaccgccgcagccttggccc	11	15	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:2817596G>A	uc002crk.2	+	11	7616	c.7067G>A	c.(7066-7068)AGA>AAA	p.R2356K	SRRM2_uc002crj.1_Missense_Mutation_p.R2260K|SRRM2_uc002crl.1_Missense_Mutation_p.R2356K|SRRM2_uc010bsu.1_Missense_Mutation_p.R2260K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2356	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCCGGCTCCAGAACCGCCGCA	0.627													0	0	0	0.007413	0	18	155										A	2817596	G	A	2817596	3	1	87	1	0	0	0	0	1	0	0	0	15168	942	33	1	7105	1	SRRM2	16	2817596	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1199329	2817596	87537157	392	26060										
BTBD12	84464	broad.mit.edu	37	chr16	3640791	3640791	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggaatggccaagcgcctcctCtggcgcctcctgctcagggg	14	15	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:3640791C>G	uc002cvp.2	-	12	3475	c.2848G>C	c.(2848-2850)GAG>CAG	p.E950Q		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	950	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						AGCGCCTCCTCTGGCGCCTCC	0.657								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.013537	0	13	54										G	3640791	C	G	3640791	3	3	87	1	0	0	0	0	1	0	0	0	1540	922	32	1	2672	1	BTBD12	16	3640791	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	823195	3640791	86713962	393	26061										
C16orf71	146562	broad.mit.edu	37	chr16	4797521	4797521	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagctctgtgccaaggggcaGagcgcccaggctcgactccc	13	15	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:4797521G>A	uc002cxn.2	+	9	1920	c.1458G>A	c.(1456-1458)CAG>CAA	p.Q486Q		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	486										central_nervous_system(1)	1						CCAAGGGGCAGAGCGCCCAGG	0.667													0	0	0	0.00308	0	7	20										A	4797521	G	A	4797521	2	1	87	1	0	0	0	0	0	0	0	1	1830	933	33	1		1	C16orf71	16	4797521	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1156730	4797521	85557232	394	26062										
NOMO1	23420	broad.mit.edu	37	chr16	14989478	14989478	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gatgcaaagagacaagccaaGaaacagaagacaaggcggac	12	8	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:14989478G>C	uc002dcv.2	+	31	3711	c.3645G>C	c.(3643-3645)AAG>AAC	p.K1215N		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1215	Cytoplasmic (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						GACAAGCCAAGAAACAGAAGA	0.607													0	0	0	0.01441	0	87	515										C	14989478	G	C	14989478	3	2	87	1	0	0	0	0	1	0	0	0	10531	933	33	1	3767	1	NOMO1	16	14989478	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10191957	14989478	75365275	395	26063										
ABCC1	4363	broad.mit.edu	37	chr16	16180768	16180768	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acatttacctcttcgatgatCccctctcagcagtggatgcc	7	14	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:16180768C>T	uc010bvi.2	+	18	2555	c.2380C>T	c.(2380-2382)CCC>TCC	p.P794S	ABCC1_uc010bvj.2_Missense_Mutation_p.P735S|ABCC1_uc010bvk.2_Intron|ABCC1_uc010bvl.2_Missense_Mutation_p.P794S|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_Missense_Mutation_p.P678S	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	794	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CTTCGATGATCCCCTCTCAGC	0.592													0	0	0	0.004482	0	8	75										T	16180768	C	T	16180768	3	4	87	1	0	0	0	0	1	0	0	0	49	855	30	1	2450	1	ABCC1	16	16180768	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1191290	16180768	74173985	396	26064										
DNAH3	55567	broad.mit.edu	37	chr16	21078642	21078642	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttcttctccaagtaatcattCagccctttctggatgtcctc	5	13	5	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:21078642C>T	uc010vbe.1	-	24	3480	c.3480G>A	c.(3478-3480)CTG>CTA	p.L1160L		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1160	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGTAATCATTCAGCCCTTTCT	0.443													0	0	0	0.00245	0	15	60										T	21078642	C	T	21078642	2	4	87	1	0	0	0	0	0	0	0	1	4603	813	29	1		1	DNAH3	16	21078642	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4897874	21078642	69276111	397	26065										
PRKCB	5579	broad.mit.edu	37	chr16	24231400	24231400	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaatgaatttgctggcttctCttatactaacccagagtttg	7	8	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:24231400C>G	uc002dmd.2	+	17	2179	c.1982C>G	c.(1981-1983)TCT>TGT	p.S661C	PRKCB_uc002dme.2_3'UTR	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	661	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	GCTGGCTTCTCTTATACTAAC	0.433													0	0	0	0.00278	0	22	54										G	24231400	C	G	24231400	3	3	87	1	0	0	0	0	1	0	0	0	12508	913	32	1	2211	1	PRKCB	16	24231400	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3152758	24231400	66123353	398	26066										
GDPD3	79153	broad.mit.edu	37	chr16	30123483	30123483	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catttcttcatgaccgagctCttctccgaggcccagatggt	9	13	4	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123483C>A	uc002dwp.2	-	6	622	c.543G>T	c.(541-543)AAG>AAT	p.K181N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.K119N|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	181	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						TGACCGAGCTCTTCTCCGAGG	0.617											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.04858e-14	0.006214	1.13522e-14	9	71										A	30123483	C	A	30123483	3	1	87	1	0	0	0	0	1	0	0	0	6325	912	32	3	433	3	GDPD3	16	30123483	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5892083	30123483	60231270	399	26067			2	117		4	4	4747	C		8.315639e-05
GDPD3	79153	broad.mit.edu	37	chr16	30123690	30123690	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgggtgtccttggaaacctCtggaacaggtcctccagacg	12	11	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123690C>A	uc002dwp.2	-	5	499	c.420G>T	c.(418-420)CAG>CAT	p.Q140H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.Q78H|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	140	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						TTGGAAACCTCTGGAACAGGT	0.622											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.58986e-06	0.008291	1.64628e-06	10	88										A	30123690	C	A	30123690	3	1	87	1	0	0	0	0	1	0	0	0	6325	912	32	3	560	3	GDPD3	16	30123690	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	207	30123690	60231063	400	26068			2	117		4	4	4747	C		8.315639e-05
GDPD3	79153	broad.mit.edu	37	chr16	30123730	30123730	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaaccatgcgccggtctgacCcgtgagcaaagtggcctggg	15	12	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123730C>A	uc002dwp.2	-	5	459	c.380G>T	c.(379-381)GGG>GTG	p.G127V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.G65V|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	127	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						CCGGTCTGACCCGTGAGCAAA	0.602											OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.33987e-11	0.008291	1.43846e-11	9	93										A	30123730	C	A	30123730	3	1	87	1	0	0	0	0	1	0	0	0	6325	623	22	4	600	4	GDPD3	16	30123730	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	40	30123730	60231023	401	26069			2	117		4	4	4747	C		8.315639e-05
MAPK3	5595	broad.mit.edu	37	chr16	30128229	30128229	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcccacctcatccgtcgggtCatagtactgctccaggtagg	11	14	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30128229C>T	uc002dws.2	-	7	1103	c.1003G>A	c.(1003-1005)GAC>AAC	p.D335N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_Missense_Mutation_p.D221N|MAPK3_uc002dwv.3_Missense_Mutation_p.D291N|MAPK3_uc002dwt.2_Missense_Mutation_p.D335N|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_Intron	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	335					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	TCCGTCGGGTCATAGTACTGC	0.627													0	0	0	0.004007	0	16	135										T	30128229	C	T	30128229	3	4	87	1	0	0	0	0	1	0	0	0	9279	826	29	1	201	1	MAPK3	16	30128229	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4499	30128229	60226524	402	26070			2	117		4	4	4747	C		8.315639e-05
CES3	23491	broad.mit.edu	37	chr16	66998585	66998585	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atcacacagagtggggtcatCaccaccccagggatcatcga	10	13	4	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:66998585C>T	uc002eqt.2	+	6	847	c.774C>T	c.(772-774)ATC>ATT	p.I258I	CES3_uc010cdz.2_Silent_p.I258I|CES3_uc010cea.2_RNA|CES3_uc010viw.1_5'Flank	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	258						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GTGGGGTCATCACCACCCCAG	0.587													0	0	0	0.012213	0	32	23										T	66998585	C	T	66998585	2	4	87	1	0	0	0	0	0	0	0	1	3271	816	29	1		1	CES3	16	66998585	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	36870356	66998585	23356168	403	26071										
LRRC36	55282	broad.mit.edu	37	chr16	67404900	67404900	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgctgtacttgtcaatgtaGagcaacaattatctaccagc	7	10	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:67404900G>C	uc002esv.2	+	9	1268	c.1249G>C	c.(1249-1251)GAG>CAG	p.E417Q	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Missense_Mutation_p.E149Q|LRRC36_uc002esx.2_Missense_Mutation_p.E296Q|LRRC36_uc010vjk.1_Missense_Mutation_p.E296Q|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	417											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TGTCAATGTAGAGCAACAATT	0.433													0	0	0	0.001984	0	7	96										C	67404900	G	C	67404900	3	2	87	1	0	0	0	0	1	0	0	0	8990	943	33	1	1311	1	LRRC36	16	67404900	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	406315	67404900	22949853	404	26072										
WWP2	11060	broad.mit.edu	37	chr16	69964146	69964146	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cacctttaaggatcctcgccCggggtttgagtcggggtaag	14	10	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:69964146C>T	uc002exu.1	+	14	1519	c.1430C>T	c.(1429-1431)CCG>CTG	p.P477L	WWP2_uc002exv.1_Missense_Mutation_p.P477L|WWP2_uc010vlm.1_Missense_Mutation_p.P361L|WWP2_uc010vln.1_Missense_Mutation_p.P95L|WWP2_uc002exw.1_Missense_Mutation_p.P38L|uc002exx.1_5'Flank|MIR140_hsa-mir-140|MI0000456_5'Flank	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	477	WW 4.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						GATCCTCGCCCGGGGTTTGAG	0.597											OREG0023910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	32	10										T	69964146	C	T	69964146	3	4	87	1	0	0	0	0	1	0	0	0	17413	652	23	2	1480	2	WWP2	16	69964146	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2559246	69964146	20390607	405	26073										
AP1G1	164	broad.mit.edu	37	chr16	71799484	71799484	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatacgaactaattggggcaCaagctgcagagaagaaagat	11	6	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:71799484C>G	uc010cgg.2	-	7	960	c.646G>C	c.(646-648)GTG>CTG	p.V216L	AP1G1_uc002fba.2_Missense_Mutation_p.V219L|AP1G1_uc002fbb.2_Missense_Mutation_p.V239L|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	216					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				AATTGGGGCACAAGCTGCAGA	0.408													0	0	0	0.001855	0	12	32										G	71799484	C	G	71799484	3	3	87	1	0	0	0	0	1	0	0	0	732	478	17	4	1890	4	AP1G1	16	71799484	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1835338	71799484	18555269	406	26074										
LRRC50	123872	broad.mit.edu	37	chr16	84199455	84199455	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaggagagacagcagtgggaGagcagggagcggaagaagat	20	4	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:84199455G>A	uc002fhl.3	+	7	1111	c.930G>A	c.(928-930)GAG>GAA	p.E310E	LRRC50_uc010vnw.1_Silent_p.E58E	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	310					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						AGCAGTGGGAGAGCAGGGAGC	0.522									Kartagener_syndrome				0	0	0	0.008291	0	9	91										A	84199455	G	A	84199455	2	1	87	1	0	0	0	0	0	0	0	1	9009	933	33	1		1	LRRC50	16	84199455	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	12399971	84199455	6155298	407	26075										
ZNF276	92822	broad.mit.edu	37	chr16	89800365	89800365	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	accacgaggaggtccgggagCggccctgcccccaccctggc	14	18	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:89800365C>T	uc002fos.3	+	9	1490	c.1393C>T	c.(1393-1395)CGG>TGG	p.R465W	ZNF276_uc010ciq.2_Missense_Mutation_p.R251W|ZNF276_uc002fop.2_Missense_Mutation_p.R373W|ZNF276_uc002foq.3_Missense_Mutation_p.R390W|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Missense_Mutation_p.R251W|ZNF276_uc010cis.2_Missense_Mutation_p.R224W|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Missense_Mutation_p.R303W|ZNF276_uc010cit.1_Missense_Mutation_p.R224W	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	465	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGTCCGGGAGCGGCCCTGCCC	0.627													0	0	0	0.013537	0	13	19										T	89800365	C	T	89800365	3	4	87	1	0	0	0	0	1	0	0	0	17808	759	27	2	1427	2	ZNF276	16	89800365	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5600910	89800365	554388	408	26076										
ZNF276	92822	broad.mit.edu	37	chr16	89800436	89800436	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgcagcgccacgtgaagctCatccacacaggtacgcctat	9	15	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:89800436C>T	uc002fos.3	+	9	1561	c.1464C>T	c.(1462-1464)CTC>CTT	p.L488L	ZNF276_uc010ciq.2_Silent_p.L274L|ZNF276_uc002fop.2_Silent_p.L396L|ZNF276_uc002foq.3_Silent_p.L413L|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Silent_p.L274L|ZNF276_uc010cis.2_Silent_p.L247L|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Silent_p.L326L|ZNF276_uc010cit.1_Silent_p.L247L	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	488	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		ACGTGAAGCTCATCCACACAG	0.637													0	0	0	0.010729	0	10	19										T	89800436	C	T	89800436	2	4	87	1	0	0	0	0	0	0	0	1	17808	813	29	1		1	ZNF276	16	89800436	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	71	89800436	554317	409	26077										
DEF8	54849	broad.mit.edu	37	chr16	90016035	90016035	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggtcacgccgcgggcaggacGcgggaggccaggtccgtgca	19	13	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:90016035G>A	uc002fpn.1	+	2	251	c.162G>A	c.(160-162)ACG>ACA	p.T54T	DEF8_uc002fpl.2_Intron|DEF8_uc002fpm.2_Intron|DEF8_uc002fpo.1_Intron|DEF8_uc002fpp.1_Intron|DEF8_uc010vpq.1_Intron|DEF8_uc010vpr.1_Intron	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	54					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CGGGCAGGACGCGGGAGGCCA	0.677													0	0	0	0.009096	0	4	19										A	90016035	G	A	90016035	2	1	87	1	0	0	0	0	0	0	0	1	4387	1074	38	2		2	DEF8	16	90016035	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	215599	90016035	338718	410	26078										
GSG2	83903	broad.mit.edu	37	chr17	3628001	3628001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggaacccctgaggattctGagtttcgggcagatgggaag	15	8	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:3628001G>C	uc002fwp.2	+	1	805	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	258					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						TGAGGATTCTGAGTTTCGGGC	0.542													0	0	0	0.001855	0	14	70										C	3628001	G	C	3628001	3	2	87	1	0	0	0	0	1	0	0	0	6822	1291	45	1	774	1	GSG2	17	3628001	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		3628001	77567209	411	26079										
MYBBP1A	10514	broad.mit.edu	37	chr17	4455916	4455916	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atctcctgcaatgtggccttCgagacctaaggatggaggga	13	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:4455916C>T	uc002fyb.3	-	6	629	c.567G>A	c.(565-567)TCG>TCA	p.S189S	MYBBP1A_uc002fxz.3_Silent_p.S189S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	189	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						ATGTGGCCTTCGAGACCTAAG	0.572													0	0	0	0.008291	0	8	33										T	4455916	C	T	4455916	2	4	87	1	0	0	0	0	0	0	0	1	10008	871	31	1		1	MYBBP1A	17	4455916	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	827915	4455916	76739294	412	26080										
BCL6B	255877	broad.mit.edu	37	chr17	6927018	6927018	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccccgccgccccggagggaGcgctgggctacgtccgcgag	16	18	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:6927018G>C	uc002geg.2	+	2	85	c.28G>C	c.(28-30)GCG>CCG	p.A10P	BCL6B_uc010clt.1_Missense_Mutation_p.A10P	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	10						nucleus	zinc ion binding			skin(1)	1						CCCGGAGGGAGCGCTGGGCTA	0.662													0	0	0	0.003163	0	16	23										C	6927018	G	C	6927018	3	2	87	1	0	0	0	0	1	0	0	0	1377	971	34	4	30	4	BCL6B	17	6927018	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2471102	6927018	74268192	413	26081										
ATP1B2	482	broad.mit.edu	37	chr17	7557505	7557505	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gacccagctgggcaactgctCcggcattggggactccaccc	12	16	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:7557505C>G	uc002gif.1	+	4	1065	c.482C>G	c.(481-483)TCC>TGC	p.S161C		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	161	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GGCAACTGCTCCGGCATTGGG	0.562													0	0	0	0.013114	0	45	214										G	7557505	C	G	7557505	3	3	87	1	0	0	0	0	1	0	0	0	1133	855	30	1	496	1	ATP1B2	17	7557505	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	630487	7557505	73637705	414	26082										
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	48	15										T	7578406	C	T	7578406	3	4	87	1	0	0	0	0	1	0	0	0	16378	768	27	2	774	2	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	20901	7578406	73616804	415	26083										
ARHGEF15	22899	broad.mit.edu	37	chr17	8222159	8222159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggggggcgtgctctttgcctCgcgcccccgcttcacccctc	12	19	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:8222159C>T	uc002glc.2	+	12	2085	c.1964C>T	c.(1963-1965)TCG>TTG	p.S655L	ARHGEF15_uc002gld.2_Missense_Mutation_p.S655L|ARHGEF15_uc010vuw.1_Missense_Mutation_p.S544L	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	655					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CTCTTTGCCTCGCGCCCCCGC	0.642													0	0	0	0.003755	0	33	293										T	8222159	C	T	8222159	3	4	87	1	0	0	0	0	1	0	0	0	898	893	31	1	2006	1	ARHGEF15	17	8222159	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	643753	8222159	72973051	416	26084										
MYH10	4628	broad.mit.edu	37	chr17	8424198	8424198	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtaaaagttagcaatacctCtgtctgaattcctggaaaac	7	8	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:8424198C>G	uc002gll.2	-	17	2274	c.2178G>C	c.(2176-2178)CAG>CAC	p.Q726H	MYH10_uc002glm.2_Missense_Mutation_p.Q757H|MYH10_uc010cnx.2_Missense_Mutation_p.Q735H	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	726	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AGCAATACCTCTGTCTGAATT	0.398													0	0	0	0.000602	0	5	43										G	8424198	C	G	8424198	3	3	87	1	0	0	0	0	1	0	0	0	10030	912	32	1	3852	1	MYH10	17	8424198	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	202039	8424198	72771012	417	26085										
FAM18B2	201158	broad.mit.edu	37	chr17	15406428	15406428	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctacctgatgaaacttcctcGagggatggcccgggcagcgg	14	12	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:15406428G>A	uc002goq.2	-	6	764	c.581C>T	c.(580-582)TCG>TTG	p.S194L	CDRT4_uc010vvw.1_Missense_Mutation_p.S151L|FAM18B2_uc010vvx.1_Intron	NM_145301	NP_660344	Q96ET8	F18B2_HUMAN	hypothetical protein LOC201158 isoform 1	194						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0872)|BRCA - Breast invasive adenocarcinoma(8;0.0581)|READ - Rectum adenocarcinoma(1115;0.0967)		AAACTTCCTCGAGGGATggcc	0.264													0	0	0	0.004672	0	3	20										A	15406428	G	A	15406428	3	1	87	1	0	0	0	0	1	0	0	0	5520	1059	37	1	253	1	FAM18B2	17	15406428	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6982230	15406428	65788782	418	26086										
TRIM16	10626	broad.mit.edu	37	chr17	15532172	15532172	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggccagctttgagtggggtCtccatgtcactgtaccaggc	14	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:15532172C>T	uc002gox.2	-	9	2009	c.1452G>A	c.(1450-1452)GAG>GAA	p.E484E	TRIM16_uc002gor.1_Intron|TRIM16_uc002gow.2_Silent_p.E268E|TRIM16_uc002goy.2_Silent_p.E354E	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	484	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		TGAGTGGGGTCTCCATGTCAC	0.552													0	0	0	0.010504	0	21	80										T	15532172	C	T	15532172	2	4	87	1	0	0	0	0	0	0	0	1	16488	912	32	1		1	TRIM16	17	15532172	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	125744	15532172	65663038	419	26087										
TOP3A	7156	broad.mit.edu	37	chr17	18188586	18188586	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttccagttcagcccggaggtCaggcttagacatttcatagc	10	11	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:18188586C>T	uc002gsx.1	-	15	1976	c.1747G>A	c.(1747-1749)GAC>AAC	p.D583N	TOP3A_uc010cpz.1_Missense_Mutation_p.D35N|TOP3A_uc010vxr.1_Missense_Mutation_p.D113N|TOP3A_uc002gsw.1_Missense_Mutation_p.D35N|TOP3A_uc010vxs.1_Missense_Mutation_p.D481N	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	583					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GCCCGGAGGTCAGGCTTAGAC	0.517													0	0	0	0.004007	0	17	61										T	18188586	C	T	18188586	3	4	87	1	0	0	0	0	1	0	0	0	16364	826	29	1	1278	1	TOP3A	17	18188586	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2656414	18188586	63006624	420	26088										
RPL23A	6147	broad.mit.edu	37	chr17	27047838	27047838	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccgcacgtcacccaccttcCggcggccgaagacactgcga	10	18	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:27047838C>T	uc002hci.2	+	2	163	c.139C>T	c.(139-141)CGG>TGG	p.R47W	RAB34_uc002hce.2_5'Flank|RAB34_uc002hcg.2_5'Flank|RAB34_uc002hcf.2_5'Flank|RAB34_uc010was.1_5'Flank|RAB34_uc010wat.1_5'Flank|RAB34_uc002hch.2_5'Flank|RAB34_uc010wau.1_5'Flank|RAB34_uc010wav.1_5'Flank|RPL23A_uc002hck.1_RNA|SNORD4A_uc002hcl.2_5'Flank|SNORD42A_uc002hcm.1_5'Flank|SNORD4B_uc002hcn.1_5'Flank	NM_000984	NP_000975	P62750	RL23A_HUMAN	ribosomal protein L23a	47					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			ovary(1)	1	Lung NSC(42;0.00431)					ACCCACCTTCCGGCGGCCGAA	0.537											OREG0024282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	19	49										T	27047838	C	T	27047838	3	4	87	1	0	0	0	0	1	0	0	0	13571	643	23	2	145	2	RPL23A	17	27047838	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	8859252	27047838	54147372	421	26089										
CPD	1362	broad.mit.edu	37	chr17	28747979	28747979	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgggagaacaatcgtgagtCtttgatcacattgattgaaa	10	5	2	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:28747979C>T	uc002hfb.1	+	3	1130	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F	CPD_uc010wbo.1_Missense_Mutation_p.S125F|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	372	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AATCGTGAGTCTTTGATCACA	0.398													0	0	0	0.001168	0	5	61										T	28747979	C	T	28747979	3	4	87	1	0	0	0	0	1	0	0	0	3798	913	32	1	1125	1	CPD	17	28747979	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1700141	28747979	52447231	422	26090										
CPD	1362	broad.mit.edu	37	chr17	28749808	28749808	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgacacgacagaggctgtatCaactgctagcacagttgcta	10	10	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:28749808C>G	uc002hfb.1	+	5	1439	c.1424C>G	c.(1423-1425)TCA>TGA	p.S475*	CPD_uc010wbo.1_Nonsense_Mutation_p.S228*|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	475	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						GAGGCTGTATCAACTGCTAGC	0.448													0	0	0	0.001984	0	7	117										G	28749808	C	G	28749808	4	3	87	1	0	0	0	0	0	1	0	0	3798	838	29	1	1442	1	CPD	17	28749808	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1829	28749808	52445402	423	26091										
ATAD5	79915	broad.mit.edu	37	chr17	29184080	29184080	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aatgtggtattgctcttggtGaattttcaacattgaattca	8	5	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:29184080G>A	uc002hfs.1	+	8	3089	c.2743G>A	c.(2743-2745)GAA>AAA	p.E915K	ATAD5_uc002hft.1_Missense_Mutation_p.E812K	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	915					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGCTCTTGGTGAATTTTCAAC	0.353													0	0	0	0.006122	0	19	43										A	29184080	G	A	29184080	3	1	87	1	0	0	0	0	1	0	0	0	1076	1291	45	1	2773	1	ATAD5	17	29184080	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	434272	29184080	52011130	424	26092										
ATAD5	79915	broad.mit.edu	37	chr17	29221167	29221167	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcagtcagcagctaatttaGagtaagtcttacttccttta	7	8	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:29221167G>C	uc002hfs.1	+	21	5642	c.5296G>C	c.(5296-5298)GAC>CAC	p.D1766H		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1766					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCTAATTTAGAGTAAGTCTT	0.294													0	0	0	0.009096	0	4	31										C	29221167	G	C	29221167	3	2	87	1	0	0	0	0	1	0	0	0	1076	956	33	1	5378	1	ATAD5	17	29221167	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	37087	29221167	51974043	425	26093										
RHOT1	55288	broad.mit.edu	37	chr17	30525994	30525994	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tacctcctgattgcactactGaattaaatcatcatgcatat	4	10	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:30525994G>A	uc002hgz.2	+	12	1137	c.898G>A	c.(898-900)GAA>AAA	p.E300K	RHOT1_uc002hgw.2_Missense_Mutation_p.E300K|RHOT1_uc002hgy.2_Missense_Mutation_p.E300K|RHOT1_uc002hha.2_Missense_Mutation_p.E173K|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_Missense_Mutation_p.E173K|RHOT1_uc010wby.1_Missense_Mutation_p.E300K|RHOT1_uc002hhb.2_Missense_Mutation_p.E279K|RHOT1_uc002hgv.2_Missense_Mutation_p.E300K	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	300	Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				TTGCACTACTGAATTAAATCA	0.239													0	0	0	0.005443	0	26	82										A	30525994	G	A	30525994	3	1	87	1	0	0	0	0	1	0	0	0	13343	1291	45	1	944	1	RHOT1	17	30525994	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1304827	30525994	50669216	426	26094										
RDM1	201299	broad.mit.edu	37	chr17	34251717	34251717	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aagaacttcaggctttgcttCggaagtggcaccatgctatc	10	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:34251717C>T	uc002hkh.2	-	4	508	c.459G>A	c.(457-459)CCG>CCA	p.P153P	RDM1_uc010cty.2_Intron|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Silent_p.P130P|RDM1_uc002hkg.3_Silent_p.P130P|RDM1_uc010cub.2_Intron|RDM1_uc010cud.2_Silent_p.P153P|RDM1_uc010cuf.2_Intron|RDM1_uc010cue.2_Intron|RDM1_uc010cug.2_Intron|RDM1_uc010cuc.2_Intron|RDM1_uc010wco.1_Intron|RDM1_uc010wcp.1_Silent_p.P130P|RDM1_uc002hki.2_Silent_p.P153P	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	153					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGCTTTGCTTCGGAAGTGGCA	0.468								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.008361	0	32	82										T	34251717	C	T	34251717	2	4	87	1	0	0	0	0	0	0	0	1	13197	871	31	1		1	RDM1	17	34251717	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3725723	34251717	46943493	427	26095										
MRM1	79922	broad.mit.edu	37	chr17	34964210	34964210	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgagttgcttggagttcctCtgggaacggcctactctcct	11	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:34964210C>T	uc002hne.2	+	3	956	c.741C>T	c.(739-741)CTC>CTT	p.L247L	MRM1_uc002hnf.2_Silent_p.L52L	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	247					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGGAGTTCCTCTGGGAACGGC	0.612													0	0	0	0.003163	0	15	87										T	34964210	C	T	34964210	2	4	87	1	0	0	0	0	0	0	0	1	9771	900	32	1		1	MRM1	17	34964210	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	712493	34964210	46231000	428	26096										
ACACA	31	broad.mit.edu	37	chr17	35614676	35614676	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaaagcagtgaccaaactgaGaatcagcaaattcatgaagt	8	7	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:35614676G>C	uc002hnm.2	-	14	1855	c.1664C>G	c.(1663-1665)TCT>TGT	p.S555C	ACACA_uc002hnk.2_Missense_Mutation_p.S477C|ACACA_uc002hnl.2_Missense_Mutation_p.S497C|ACACA_uc002hnn.2_Missense_Mutation_p.S555C|ACACA_uc002hno.2_Missense_Mutation_p.S592C|ACACA_uc010cuz.2_Missense_Mutation_p.S555C	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	555	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ACCAAACTGAGAATCAGCAAA	0.393													0	0	0	0.008291	0	11	63										C	35614676	G	C	35614676	3	2	87	1	0	0	0	0	1	0	0	0	106	942	33	1	5548	1	ACACA	17	35614676	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	650466	35614676	45580534	429	26097										
ZPBP2	124626	broad.mit.edu	37	chr17	38027018	38027018	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	attttaagctttctaaaaaaGaaatagtggaccccacctac	5	9	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:38027018G>T	uc002hte.2	+	3	343	c.190G>T	c.(190-192)GAA>TAA	p.E64*	ZPBP2_uc002htf.2_Nonsense_Mutation_p.E42*	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	64					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			TTCTAAAAAAGAAATAGTGGA	0.284													1	0	3.59834e-05	0.001168	3.69621e-05	5	58										T	38027018	G	T	38027018	4	4	87	1	0	0	0	0	0	1	0	0	18217	943	33	3	200	3	ZPBP2	17	38027018	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2412342	38027018	43168192	430	26098										
ZPBP2	124626	broad.mit.edu	37	chr17	38027764	38027764	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctggacagctgatggtgaaaGattttttggagcctttgtct	12	6	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:38027764G>C	uc002hte.2	+	4	445	c.292G>C	c.(292-294)GAT>CAT	p.D98H	ZPBP2_uc002htf.2_Missense_Mutation_p.D76H	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	98					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATGGTGAAAGATTTTTTGGA	0.284													0	0	0	0.006122	0	17	131										C	38027764	G	C	38027764	3	2	87	1	0	0	0	0	1	0	0	0	18217	942	33	1	306	1	ZPBP2	17	38027764	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	746	38027764	43167446	431	26099										
ACLY	47	broad.mit.edu	37	chr17	40028327	40028327	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aggctggagaccaggtctttCccagctcgcgcacaaatgat	11	12	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:40028327C>T	uc002hyg.2	-	24	2914	c.2751G>A	c.(2749-2751)GGG>GGA	p.G917G	ACLY_uc002hyh.2_Silent_p.G907G|ACLY_uc002hyi.2_Silent_p.G971G|ACLY_uc010wfx.1_Silent_p.G961G|ACLY_uc010wfy.1_Silent_p.G646G	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	917				AGKD -> TAVE (in Ref. 1; CAA45614).	ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCAGGTCTTTCCCAGCTCGCG	0.567													0	0	0	0.009096	0	4	37										T	40028327	C	T	40028327	2	4	87	1	0	0	0	0	0	0	0	1	143	842	30	1		1	ACLY	17	40028327	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2000563	40028327	41166883	432	26100										
ACLY	47	broad.mit.edu	37	chr17	40039486	40039486	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tattcctcagtgcccccaatCtgccaaggaatggggaatga	10	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:40039486C>A	uc002hyg.2	-	20	2318	c.2155_splice	c.e20-1	p.I719_splice	ACLY_uc002hyh.2_Splice_Site_p.I709_splice|ACLY_uc002hyi.2_Splice_Site_p.I773_splice|ACLY_uc010wfx.1_Splice_Site_p.I763_splice|ACLY_uc010wfy.1_Splice_Site_p.I448_splice	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1						ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TGCCCCCAATCTGCCAAGGAA	0.517													1	0	1.33986e-20	0.004656	1.4679e-20	26	37										A	40039486	C	A	40039486	5	1	87	1	0	0	0	0	0	0	1	0	143	927	32	3	1191	3	ACLY	17	40039486	Splice_Site	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11159	40039486	41155724	433	26101										
PLEKHM1	9842	broad.mit.edu	37	chr17	43515225	43515225	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cggggtcagcagatgggcatCaggcgaaaatgttctgttcc	14	9	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:43515225C>T	uc002ija.2	-	12	3340	c.3170G>A	c.(3169-3171)TGA>TAA	p.*1057*	PLEKHM1_uc010wjm.1_Silent_p.*1029*|PLEKHM1_uc002ijb.2_Silent_p.*532*	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	1057					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					AGATGGGCATCAGGCGAAAAT	0.627													0	0	0	0.000602	0	5	42										T	43515225	C	T	43515225	2	4	87	1	0	0	0	0	0	0	0	1	12080	837	29	1		1	PLEKHM1	17	43515225	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3475739	43515225	37679985	434	26102										
OSBPL7	114881	broad.mit.edu	37	chr17	45897373	45897373	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agaggccacttcctcttcttGagcaggtgaccttcctgcct	9	14	2	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45897373G>A	uc002ilx.1	-	3	368	c.165C>T	c.(163-165)CTC>CTT	p.L55L		NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	55	PH.				lipid transport		lipid binding				0						TCCTCTTCTTGAGCAGGTGAC	0.652													0	0	0	0.004672	0	3	24										A	45897373	G	A	45897373	2	1	87	1	0	0	0	0	0	0	0	1	11282	1277	45	1		1	OSBPL7	17	45897373	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2382148	45897373	35297837	435	26103										
OSBPL7	114881	broad.mit.edu	37	chr17	45897592	45897592	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctgagcactgctgggctttGaggactgagcgctctcaggc	15	11	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45897592G>C	uc002ilx.1	-	2	256	c.53C>G	c.(52-54)TCA>TGA	p.S18*		NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	18					lipid transport		lipid binding				0						GCTGGGCTTTGAGGACTGAGC	0.637													0	0	0	0.009096	0	4	24										C	45897592	G	C	45897592	4	2	87	1	0	0	0	0	0	1	0	0	11282	1294	45	1	2563	1	OSBPL7	17	45897592	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	219	45897592	35297618	436	26104										
ABCC3	8714	broad.mit.edu	37	chr17	48735563	48735563	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttttctccgcaaagaatgtcGaccctgtgagtttcccatgg	9	11	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:48735563G>A	uc002isl.2	+	5	687	c.607G>A	c.(607-609)GAC>AAC	p.D203N	ABCC3_uc002isk.3_Missense_Mutation_p.D203N	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	203	Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AAAGAATGTCGACCCTGTGAG	0.567													0	0	0	0.00499	0	15	74										A	48735563	G	A	48735563	3	1	87	1	0	0	0	0	1	0	0	0	54	1058	37	1	625	1	ABCC3	17	48735563	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2837971	48735563	32459647	437	26105										
TRIM25	7706	broad.mit.edu	37	chr17	54991173	54991173	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttcttgtgcagctgcggtcgCgcctggtagacggcgcggca	16	12	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:54991173C>T	uc002iut.2	-	1	237	c.177G>A	c.(175-177)GCG>GCA	p.A59A	TRIM25_uc010dcj.2_5'UTR	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	59					innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GCTGCGGTCGCGCCTGGTAGA	0.692													0	0	0	0.004672	0	3	7										T	54991173	C	T	54991173	2	4	87	1	0	0	0	0	0	0	0	1	16496	755	27	2		2	TRIM25	17	54991173	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6255610	54991173	26204037	438	26106										
BZRAP1	9256	broad.mit.edu	37	chr17	56405156	56405156	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctgccggaggagtatcagcGatgcttggggctgcactgct	16	10	1	0	rs148586326		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:56405156G>A	uc002ivx.3	-	1	997	c.126C>T	c.(124-126)ATC>ATT	p.I42I	BZRAP1_uc010dcs.2_Silent_p.I42I|BZRAP1_uc010wnt.1_Silent_p.I42I|uc010dct.1_5'Flank|uc010dcu.1_5'Flank	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	42						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGTATCAGCGATGCTTGGGG	0.637													0	0	0	0.009096	0	4	31										A	56405156	G	A	56405156	2	1	87	1	0	0	0	0	0	0	0	1	1577	1048	37	1		1	BZRAP1	17	56405156	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1413983	56405156	24790054	439	26107										
INTS2	57508	broad.mit.edu	37	chr17	59949655	59949655	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagtaatgcatttttcaattCttccctggtaacttccggag	7	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:59949655C>T	uc002izn.2	-	20	2849	c.2773G>A	c.(2773-2775)GAA>AAA	p.E925K	INTS2_uc002izm.2_Missense_Mutation_p.E917K	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	925					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TTTTTCAATTCTTCCCTGGTA	0.388													0	0	0	0.00245	0	14	28										T	59949655	C	T	59949655	3	4	87	1	0	0	0	0	1	0	0	0	7778	922	32	1	865	1	INTS2	17	59949655	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3544499	59949655	21245555	440	26108										
SCN4A	6329	broad.mit.edu	37	chr17	62018968	62018968	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgacactggtgcccgggttCtccaggttggggtcacagtc	14	11	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:62018968C>T	uc002jds.1	-	24	4751	c.4674G>A	c.(4672-4674)GAG>GAA	p.E1558E		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1558	IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TGCCCGGGTTCTCCAGGTTGG	0.602													0	0	0	0.001855	0	13	28										T	62018968	C	T	62018968	2	4	87	1	0	0	0	0	0	0	0	1	13920	912	32	1		1	SCN4A	17	62018968	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2069313	62018968	19176242	441	26109										
CACNG1	786	broad.mit.edu	37	chr17	65052309	65052309	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcctctttctcggcggtctCgccctcctgctgttctccct	7	19	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:65052309C>T	uc002jfu.2	+	4	662	c.591C>T	c.(589-591)CTC>CTT	p.L197L		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	197	Helical; (Potential).				muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	TCGGCGGTCTCGCCCTCCTGC	0.612													0	0	0	0.010729	0	11	63										T	65052309	C	T	65052309	2	4	87	1	0	0	0	0	0	0	0	1	2556	871	31	1		1	CACNG1	17	65052309	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3033341	65052309	16142901	442	26110										
MAP2K6	5608	broad.mit.edu	37	chr17	67519677	67519677	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtcaagccttctaatgtactCatcaatgctctcggtcaagt	7	11	6	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:67519677C>T	uc002jij.2	+	8	846	c.558C>T	c.(556-558)CTC>CTT	p.L186L		NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	186	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					CTAATGTACTCATCAATGCTC	0.448													0	0	0	0.01441	0	75	136										T	67519677	C	T	67519677	2	4	87	1	0	0	0	0	0	0	0	1	9241	813	29	1		1	MAP2K6	17	67519677	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2467368	67519677	13675533	443	26111										
DNAI2	64446	broad.mit.edu	37	chr17	72297244	72297244	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaagttgtgatcttggacatCaccaagaaggaacagttgga	12	6	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:72297244C>T	uc002jkf.2	+	8	1023	c.924C>T	c.(922-924)ATC>ATT	p.I308I	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	308					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						TCTTGGACATCACCAAGAAGG	0.547									Kartagener_syndrome				0	0	0	0.01441	0	61	78										T	72297244	C	T	72297244	2	4	87	1	0	0	0	0	0	0	0	1	4610	816	29	1		1	DNAI2	17	72297244	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4777567	72297244	8897966	444	26112										
TMEM104	54868	broad.mit.edu	37	chr17	72832682	72832682	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	taccactgccgcagggacacCcagctggcctttggctgtgg	13	14	0	0	rs147463051	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:72832682C>T	uc002jls.3	+	10	1509	c.1347C>T	c.(1345-1347)ACC>ACT	p.T449T	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Silent_p.T449T	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	449	Cytoplasmic (Potential).					integral to membrane					0	all_lung(278;0.23)					GCAGGGACACCCAGCTGGCCT	0.642													0	0	0	0.009096	0	4	48										T	72832682	C	T	72832682	2	4	87	1	0	0	0	0	0	0	0	1	16015	610	22	2		2	TMEM104	17	72832682	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	535438	72832682	8362528	445	26113										
ACOX1	51	broad.mit.edu	37	chr17	73945836	73945836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atatgcttcggttaggctttCggggctgttgatatccacca	11	9	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:73945836C>T	uc002jqf.2	-	10	1731	c.1441G>A	c.(1441-1443)GAA>AAA	p.E481K	ACOX1_uc010wsq.1_Missense_Mutation_p.E443K|ACOX1_uc002jqe.2_Missense_Mutation_p.E481K|ACOX1_uc010wsr.1_Missense_Mutation_p.E413K	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	481					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						GTTAGGCTTTCGGGGCTGTTG	0.572													0	0	0	0.00308	0	7	55										T	73945836	C	T	73945836	3	4	87	1	0	0	0	0	1	0	0	0	158	893	31	1	561	1	ACOX1	17	73945836	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1113154	73945836	7249374	446	26114										
GATA6	2627	broad.mit.edu	37	chr18	19762943	19762943	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catgactccaacttccacctCttctaactcagatgattgca	4	14	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:19762943C>G	uc002ktt.1	+	6	1824	c.1559C>G	c.(1558-1560)TCT>TGT	p.S520C	GATA6_uc002ktu.1_Missense_Mutation_p.S520C	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	520					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			ACTTCCACCTCTTCTAACTCA	0.393													0	0	0	0.01441	0	76	51										G	19762943	C	G	19762943	3	3	87	1	0	0	0	0	1	0	0	0	6258	913	32	1	1577	1	GATA6	18	19762943	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		19762943	58314305	447	26115										
NPC1	4864	broad.mit.edu	37	chr18	21121061	21121061	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tctcatccagtcctttagcaGaagtggagaataggagtttt	10	7	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:21121061G>C	uc002kum.3	-	16	2759	c.2485C>G	c.(2485-2487)CTG>GTG	p.L829V	NPC1_uc010xaz.1_Missense_Mutation_p.L562V|NPC1_uc010xba.1_Missense_Mutation_p.L674V	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	829					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TCCTTTAGCAGAAGTGGAGAA	0.443													0	0	0	0.007413	0	18	186										C	21121061	G	C	21121061	3	2	87	1	0	0	0	0	1	0	0	0	10570	933	33	1	1391	1	NPC1	18	21121061	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1358118	21121061	56956187	448	26116										
NPC1	4864	broad.mit.edu	37	chr18	21123451	21123451	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctacagtctcagaaaaggatGacaggaacatactgggagcc	11	9	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:21123451G>A	uc002kum.3	-	14	2487	c.2213C>T	c.(2212-2214)TCA>TTA	p.S738L	NPC1_uc010xaz.1_Missense_Mutation_p.S471L|NPC1_uc010xba.1_Missense_Mutation_p.S583L	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	738	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAAAAGGATGACAGGAACAT	0.453													0	0	0	0.001855	0	11	151										A	21123451	G	A	21123451	3	1	87	1	0	0	0	0	1	0	0	0	10570	1294	45	1	1671	1	NPC1	18	21123451	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2390	21123451	56953797	449	26117										
ASXL3	80816	broad.mit.edu	37	chr18	31323636	31323636	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagtgcaaacactacaatttCtgcttgtaatataagcatgt	6	8	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:31323636C>T	uc010dmg.1	+	12	3879	c.3824C>T	c.(3823-3825)TCT>TTT	p.S1275F	ASXL3_uc002kxq.2_Missense_Mutation_p.S982F	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1275	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACTACAATTTCTGCTTGTAAT	0.393													0	0	0	0.001168	0	5	77										T	31323636	C	T	31323636	3	4	87	1	0	0	0	0	1	0	0	0	1068	913	32	1	3870	1	ASXL3	18	31323636	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	10200185	31323636	46753612	450	26118										
MYO5B	4645	broad.mit.edu	37	chr18	47500910	47500910	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggtggtgaccagcttgcgatGacacagccagtgctccatct	12	12	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:47500910G>A	uc002leb.2	-	10	1420	c.1132C>T	c.(1132-1134)CAT>TAT	p.H378Y	MYO5B_uc002lec.1_Missense_Mutation_p.H377Y	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	378	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGCTTGCGATGACACAGCCAG	0.577													0	0	0	0.01441	0	49	37										A	47500910	G	A	47500910	3	1	87	1	0	0	0	0	1	0	0	0	10079	1290	45	1	4538	1	MYO5B	18	47500910	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	16177274	47500910	30576338	451	26119										
C18orf54	162681	broad.mit.edu	37	chr18	51898905	51898905	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aacaaatgttatttaaccttCaagcagtacaagaacgtttt	5	7	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:51898905C>T	uc002lfn.3	+	6	1029	c.913C>T	c.(913-915)CAA>TAA	p.Q305*	C18orf54_uc002lfo.3_Nonsense_Mutation_p.Q466*	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	305						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		ATTTAACCTTCAAGCAGTACA	0.338													0	0	0	0.00333	0	25	64										T	51898905	C	T	51898905	4	4	87	1	0	0	0	0	0	1	0	0	1904	827	29	1	931	1	C18orf54	18	51898905	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4397995	51898905	26178343	452	26120										
CCDC102B	79839	broad.mit.edu	37	chr18	66564576	66564576	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccaggtgaaagaaatggaaGagcttttggataagaaaaat	11	3	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:66564576G>A	uc002lkk.2	+	8	1397	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K	CCDC102B_uc002lki.2_Missense_Mutation_p.E392K|CCDC102B_uc002lkj.1_Missense_Mutation_p.E392K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	392	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGAAATGGAAGAGCTTTTGGA	0.393													0	0	0	0.010729	0	12	83										A	66564576	G	A	66564576	3	1	87	1	0	0	0	0	1	0	0	0	2737	943	33	1	1192	1	CCDC102B	18	66564576	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	14665671	66564576	11512672	453	26121										
CNDP2	55748	broad.mit.edu	37	chr18	72186206	72186206	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tttggtgttgagccagacttGaccagggaaggcggcagtat	15	7	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:72186206G>C	uc002llm.1	+	11	1395	c.1233G>C	c.(1231-1233)TTG>TTC	p.L411F	CNDP2_uc002lln.1_Missense_Mutation_p.L327F|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	411						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AGCCAGACTTGACCAGGGAAG	0.557													0	0	0	0.005524	0	36	32										C	72186206	G	C	72186206	3	2	87	1	0	0	0	0	1	0	0	0	3594	1281	45	1	1271	1	CNDP2	18	72186206	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5621630	72186206	5891042	454	26122										
CSNK1G2	1455	broad.mit.edu	37	chr19	1969891	1969891	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggaccagctcgggggtcctGatggtgggccccaacttccg	16	13	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:1969891G>A	uc002lul.3	+	3	643	c.120G>A	c.(118-120)CTG>CTA	p.L40L	CSNK1G2_uc010dsu.2_5'UTR	NM_001319	NP_001310	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	40					sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			stomach(1)	1		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGGTCCTGATGGTGGGCC	0.706													0	0	0	0.008291	0	8	4										A	1969891	G	A	1969891	2	1	87	1	0	0	0	0	0	0	0	1	3955	1277	45	1		1	CSNK1G2	19	1969891	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		1969891	57159092	455	26123										
NCLN	56926	broad.mit.edu	37	chr19	3186161	3186161	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgccgccgacgccgcgcacGagttcaccgtgtaccgcatg	12	17	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:3186161G>C	uc002lxi.2	+	1	287	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	NCLN_uc002lxh.1_RNA	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	45	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCGCGCACGAGTTCACCGT	0.721													0	0	0	0.00308	0	7	8										C	3186161	G	C	3186161	3	2	87	1	0	0	0	0	1	0	0	0	10227	1059	37	1	135	1	NCLN	19	3186161	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1216270	3186161	55942822	456	26124										
ZNF799	90576	broad.mit.edu	37	chr19	12502718	12502718	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tacaattatatggtttctttCcagtgtgaagcctctcatgt	7	8	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:12502718C>G	uc010dyt.2	-	4	644	c.494G>C	c.(493-495)GGA>GCA	p.G165A	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TGGTTTCTTTCCAGTGTGAAG	0.428													0	0	0	0.001168	0	6	100										G	12502718	C	G	12502718	3	3	87	1	0	0	0	0	1	0	0	0	18163	855	30	1	1441	1	ZNF799	19	12502718	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	9316557	12502718	46626265	457	26125										
GIPC1	10755	broad.mit.edu	37	chr19	14591576	14591576	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccactttgtgggtgttcagGgtgcagaacatcacctgcag	12	10	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:14591576G>A	uc002myt.2	-	5	573	c.303C>T	c.(301-303)ACC>ACT	p.T101T	GIPC1_uc002myu.2_Silent_p.T101T|GIPC1_uc002myv.2_Silent_p.T4T|GIPC1_uc002myw.2_Silent_p.T4T|GIPC1_uc002myx.2_Silent_p.T101T|GIPC1_uc002myy.2_Silent_p.T4T	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	101					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						GGGTGTTCAGGGTGCAGAACA	0.612											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	6	39										A	14591576	G	A	14591576	2	1	87	1	0	0	0	0	0	0	0	1	6392	1219	43	2		2	GIPC1	19	14591576	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2088858	14591576	44537407	458	26126										
ARMC6	93436	broad.mit.edu	37	chr19	19168416	19168416	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgagagctgtggacaggccaGaggggcaacctggcgccatg	17	11	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:19168416G>C	uc002nld.2	+	9	1833	c.1485G>C	c.(1483-1485)CAG>CAC	p.Q495H	ARMC6_uc002nlc.2_Missense_Mutation_p.Q470H|ARMC6_uc010xql.1_Missense_Mutation_p.Q402H|ARMC6_uc002nle.2_Missense_Mutation_p.Q470H|ARMC6_uc010xqm.1_Missense_Mutation_p.Q495H	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	495							protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GGACAGGCCAGAGGGGCAACC	0.652													0	0	0	0.001168	0	5	29										C	19168416	G	C	19168416	3	2	87	1	0	0	0	0	1	0	0	0	955	933	33	1	1436	1	ARMC6	19	19168416	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4576840	19168416	39960567	459	26127										
GMIP	51291	broad.mit.edu	37	chr19	19745863	19745863	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagggcacggtgttctatctCagccgtgcacttcgtgacca	11	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:19745863C>T	uc002nnd.2	-	16	1837	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K	GMIP_uc010xrb.1_Missense_Mutation_p.E548K|GMIP_uc010xrc.1_Missense_Mutation_p.E545K	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	574	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						TGTTCTATCTCAGCCGTGCAC	0.597													0	0	0	0.00499	0	17	92										T	19745863	C	T	19745863	3	4	87	1	0	0	0	0	1	0	0	0	6491	835	29	1	1216	1	GMIP	19	19745863	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	577447	19745863	39383120	460	26128										
ZNF208	7757	broad.mit.edu	37	chr19	22156691	22156691	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcttatgataactaagggttGagggccacttataggctttg	11	6	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:22156691G>C	uc002nqp.2	-	4	1294	c.1145C>G	c.(1144-1146)TCA>TGA	p.S382*	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTAAGGGTTGAGGGCCACTT	0.368													0	0	0	0.003163	0	12	60										C	22156691	G	C	22156691	4	2	87	1	0	0	0	0	0	1	0	0	17763	1294	45	1	2701	1	ZNF208	19	22156691	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2410828	22156691	36972292	461	26129										
SLC7A9	11136	broad.mit.edu	37	chr19	33334854	33334854	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcccggcccgccacgtaaatGagtctggaaaataacgacac	9	13	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:33334854G>A	uc002ntv.3	-	10	1098	c.981C>T	c.(979-981)CTC>CTT	p.L327L	SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Silent_p.L327L|SLC7A9_uc002ntw.3_Silent_p.L118L	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	327	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CCACGTAAATGAGTCTGGAAA	0.577													0	0	0	0.000602	0	5	37										A	33334854	G	A	33334854	2	1	87	1	0	0	0	0	0	0	0	1	14705	1277	45	1		1	SLC7A9	19	33334854	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	11178163	33334854	25794129	462	26130										
ZNF585B	92285	broad.mit.edu	37	chr19	37676275	37676275	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctaaaggccttcccacactCagcacacacgtaaggcttct	7	15	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:37676275C>T	uc002ofq.2	-	5	2418	c.2164G>A	c.(2164-2166)GAG>AAG	p.E722K	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.E536K	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	722	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCCCACACTCAGCACACACG	0.463													0	0	0	0.007413	0	18	121										T	37676275	C	T	37676275	3	4	87	1	0	0	0	0	1	0	0	0	18015	835	29	1	149	1	ZNF585B	19	37676275	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4341421	37676275	21452708	463	26131										
HIPK4	147746	broad.mit.edu	37	chr19	40886303	40886303	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggatggccagtggctcagcaGaggccccgagatgctctcct	14	13	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:40886303G>A	uc002onp.2	-	3	1880	c.1595C>T	c.(1594-1596)TCT>TTT	p.S532F		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	532						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TGGCTCAGCAGAGGCCCCGAG	0.607													0	0	0	0.001984	0	7	68										A	40886303	G	A	40886303	3	1	87	1	0	0	0	0	1	0	0	0	7119	942	33	1	263	1	HIPK4	19	40886303	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3210028	40886303	18242680	464	26132										
LIPE	3991	broad.mit.edu	37	chr19	42906092	42906092	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctctgcggcctggcgcgtctCgcggcacagcgccgctaggg	16	16	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:42906092C>G	uc002otr.2	-	10	3380	c.3103G>C	c.(3103-3105)GAG>CAG	p.E1035Q	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	1035					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TGGCGCGTCTCGCGGCACAGC	0.756													0	0	0	0.004672	0	2	3										G	42906092	C	G	42906092	3	3	87	1	0	0	0	0	1	0	0	0	8821	893	31	1	131	1	LIPE	19	42906092	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2019789	42906092	16222891	465	26133										
PSG1	5669	broad.mit.edu	37	chr19	43382132	43382132	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tctccctttatgatgtgtaaGgtgtaggatcctgcgtcctc	10	10	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43382132G>A	uc002ovb.2	-	2	501	c.363C>T	c.(361-363)ACC>ACT	p.T121T	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.T121T|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.T121T|PSG1_uc010eio.1_Silent_p.T121T|PSG1_uc002oux.1_Silent_p.T50T|PSG1_uc002ouy.1_Silent_p.T121T|PSG1_uc002ouz.1_Silent_p.T121T|PSG1_uc002ova.1_Silent_p.T121T|PSG1_uc002ovc.2_Silent_p.T121T|PSG1_uc002ovd.1_Silent_p.T121T	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	121	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGATGTGTAAGGTGTAGGATC	0.478													0	0	0	0.01441	0	31	280										A	43382132	G	A	43382132	2	1	87	1	0	0	0	0	0	0	0	1	12653	987	35	2		2	PSG1	19	43382132	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	476040	43382132	15746851	466	26134										
PSG7	5676	broad.mit.edu	37	chr19	43430668	43430668	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acattgatagggtcctgtttCatttctcgtgacactgggta	10	8	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43430668C>T	uc002ovl.3	-	5	1012	c.910G>A	c.(910-912)GAA>AAA	p.E304K	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.E182K	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	304	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGTCCTGTTTCATTTCTCGTG	0.498													0	0	0	0.01441	0	49	276										T	43430668	C	T	43430668	3	4	87	1	0	0	0	0	1	0	0	0	12660	835	29	1	361	1	PSG7	19	43430668	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	48536	43430668	15698315	467	26135										
PSG7	5676	broad.mit.edu	37	chr19	43439684	43439684	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gcagggatgcattggaatatActgtttctcatccactgtat	9	8	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43439684A>G	uc002ovl.3	-	3	404	c.302T>C	c.(301-303)GTA>GCA	p.V101A	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	101	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				ATTGGAATATACTGTTTCTCA	0.418													0	0	0	0.003755	0	30	585										G	43439684	A	G	43439684	3	3	87	1	0	0	0	0	1	0	0	0	12660	391	14	5	977	5	PSG7	19	43439684	Missense_Mutation	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	9016	43439684	15689299	468	26136										
ZNF230	7773	broad.mit.edu	37	chr19	44514752	44514752	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcagctcttcgtattcaccaGagagttcacttgagagagaa	9	9	4	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:44514752G>C	uc002oyb.1	+	5	812	c.561G>C	c.(559-561)CAG>CAC	p.Q187H		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	187	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GTATTCACCAGAGAGTTCACT	0.458													0	0	0	0.01441	0	53	125										C	44514752	G	C	44514752	3	2	87	1	0	0	0	0	1	0	0	0	17781	933	33	1	575	1	ZNF230	19	44514752	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1075068	44514752	14614231	469	26137										
ZC3H4	23211	broad.mit.edu	37	chr19	47569810	47569810	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggctggggtggggcaccctCggggggtggggtggcggtgg	27	7	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:47569810C>T	uc002pga.3	-	15	3753	c.3715G>A	c.(3715-3717)GAG>AAG	p.E1239K	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1239							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGGGCACCCTCGGGGGGTGGG	0.701													0	0	0	0.009096	0	4	7										T	47569810	C	T	47569810	3	4	87	1	0	0	0	0	1	0	0	0	17567	893	31	1	200	1	ZC3H4	19	47569810	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3055058	47569810	11559173	470	26138										
RRAS	6237	broad.mit.edu	37	chr19	50138855	50138855	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acaggaggacgcaggggcagCccccgcccttcttcctgggg	15	15	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:50138855C>T	uc002pop.1	-	6	680	c.635G>A	c.(634-636)GGC>GAC	p.G212D		NM_006270	NP_006261	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	212					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		GCAGGGGCAGCCCCCGCCCTT	0.547													0	0	0	0.01441	0	50	72										T	50138855	C	T	50138855	3	4	87	1	0	0	0	0	1	0	0	0	13676	739	26	2	25	2	RRAS	19	50138855	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2569045	50138855	8990128	471	26139										
NAPSA	9476	broad.mit.edu	37	chr19	50864260	50864260	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgctccaccagtacatccatCgggggccgaactccttccac	8	17	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:50864260C>T	uc002prx.2	-	5	659	c.606G>A	c.(604-606)CCG>CCA	p.P202P	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	202					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		GTACATCCATCGGGGGCCGAA	0.532													0	0	0	0.00623	0	38	77										T	50864260	C	T	50864260	2	4	87	1	0	0	0	0	0	0	0	1	10166	871	31	1		1	NAPSA	19	50864260	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	725405	50864260	8264723	472	26140										
SHANK1	50944	broad.mit.edu	37	chr19	51219704	51219704	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctgctgcttggccgtccagAtggtggcatcggggttgaag	16	10	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:51219704A>G	uc002psx.1	-	2	306	c.287T>C	c.(286-288)ATC>ACC	p.I96T		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	96					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGCCGTCCAGATGGTGGCATC	0.637													0	0	0	0.010504	0	20	45										G	51219704	A	G	51219704	3	3	87	1	0	0	0	0	1	0	0	0	14264	333	12	5	6286	5	SHANK1	19	51219704	Missense_Mutation	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	355444	51219704	7909279	473	26141										
LIM2	3982	broad.mit.edu	37	chr19	51890572	51890572	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgcccaggcagtaccgccaCaggccctggtgggcgaagga	15	13	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:51890572C>T	uc002pwm.2	-	2	170	c.126G>A	c.(124-126)CTG>CTA	p.L42L	LIM2_uc002pwl.2_Silent_p.L42L	NM_001161748	NP_001155220	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa isoform	42	Extracellular (Potential).				cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens				0		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		AGTACCGCCACAGGCCCTGGT	0.667													0	0	0	0.00333	0	23	85										T	51890572	C	T	51890572	2	4	87	1	0	0	0	0	0	0	0	1	8795	465	17	2		2	LIM2	19	51890572	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	670868	51890572	7238411	474	26142										
DPRX	503834	broad.mit.edu	37	chr19	54139969	54139969	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtctccaccagtgtcggcctGagaaatgcagacacactacc	9	14	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54139969G>C	uc002qcf.1	+	3	354	c.303G>C	c.(301-303)CTG>CTC	p.L101L		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	101						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		GTGTCGGCCTGAGAAATGCAG	0.527													0	0	0	0.006999	0	43	85										C	54139969	G	C	54139969	2	2	87	1	0	0	0	0	0	0	0	1	4738	1277	45	1		1	DPRX	19	54139969	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	2249397	54139969	4989014	475	26143			3	118		3	3	231	N	G_C	7.641243e-06
DPRX	503834	broad.mit.edu	37	chr19	54139992	54139992	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaatgcagacacactacccaGattgcccaacgctgctcacc	6	16	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54139992G>C	uc002qcf.1	+	3	377	c.326G>C	c.(325-327)AGA>ACA	p.R109T		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	109						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		ACACTACCCAGATTGCCCAAC	0.542													0	0	0	0.00874	0	44	81										C	54139992	G	C	54139992	3	2	87	1	0	0	0	0	1	0	0	0	4738	942	33	1	336	1	DPRX	19	54139992	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	23	54139992	4988991	476	26144			3	118		3	3	231	N	G_C	7.641243e-06
DPRX	503834	broad.mit.edu	37	chr19	54140199	54140199	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgcgctccaagcttccattCtggctctcctgcctgttcat	7	15	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54140199C>G	uc002qcf.1	+	3	584	c.533C>G	c.(532-534)TCT>TGT	p.S178C		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	178						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		AGCTTCCATTCTGGCTCTCCT	0.388													0	0	0	0.008291	0	9	176										G	54140199	C	G	54140199	3	3	87	1	0	0	0	0	1	0	0	0	4738	913	32	1	543	1	DPRX	19	54140199	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	207	54140199	4988784	477	26145			3	118		3	3	231	N	G_C	7.641243e-06
VSTM1	284415	broad.mit.edu	37	chr19	54545425	54545425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gctatgccaagcatctacctCttggtggattcctcagatga	9	11	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54545425C>G	uc002qcw.3	-	6	689	c.513G>C	c.(511-513)AAG>AAC	p.K171N	VSTM1_uc010erb.2_Intron|VSTM1_uc002qcx.3_Missense_Mutation_p.K140N	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	171						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GCATCTACCTCTTGGTGGATT	0.507													0	0	0	0.012213	0	31	146										G	54545425	C	G	54545425	3	3	87	1	0	0	0	0	1	0	0	0	17225	912	32	1	213	1	VSTM1	19	54545425	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	405226	54545425	4583558	478	26146										
ZNF587	84914	broad.mit.edu	37	chr19	58370965	58370965	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tttggtcaaaagggcaacctCgttcaccatcagcgaggtca	10	11	4	0	rs146642070		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:58370965C>T	uc002qql.2	+	3	1323	c.1185C>T	c.(1183-1185)CTC>CTT	p.L395L	ZNF587_uc002qqb.2_Silent_p.L352L|ZNF587_uc010yhh.1_Silent_p.L352L|ZNF587_uc002qqi.1_Silent_p.L352L|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Silent_p.L394L	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	395	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		AGGGCAACCTCGTTCACCATC	0.468													0	0	0	0.01441	0	103	129										T	58370965	C	T	58370965	2	4	87	1	0	0	0	0	0	0	0	1	18017	871	31	1		1	ZNF587	19	58370965	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	3825540	58370965	758018	479	26147										
CHMP2A	27243	broad.mit.edu	37	chr19	59063424	59063424	+	Silent	SNP	C	C	T													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	catccagtttccccatacctCtcctcttcatcttcctcatc							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:59063424C>T	uc002qti.2	-	3	903	c.477G>A	c.(475-477)GAG>GAA	p.E159E	CHMP2A_uc002qtj.2_Silent_p.E159E|CHMP2A_uc002qtk.2_Silent_p.E159E	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	159	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCCATACCTCTCCTCTTCAT	0.517													0	0	0	0.010729	0	11	193										T	59063424	C	T	59063424	2	4	87	1	0	0	0	0	0	0	0	1	3354	912	32	1		1	CHMP2A	19	59063424	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	692459	59063424	65559	480	26148	128	2								
CHMP2A	27243	broad.mit.edu	37	chr19	59063429	59063429	+	Missense_Mutation	SNP	C	C	T													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agtttccccatacctctcctCttcatcttcctcatcaccca							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:59063429C>T	uc002qti.2	-	3	898	c.472G>A	c.(472-474)GAG>AAG	p.E158K	CHMP2A_uc002qtj.2_Missense_Mutation_p.E158K|CHMP2A_uc002qtk.2_Missense_Mutation_p.E158K	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	158	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TACCTCTCCTCTTCATCTTCC	0.512													0	0	0	0.001855	0	12	204										T	59063429	C	T	59063429	3	4	87	1	0	0	0	0	1	0	0	0	3354	922	32	1	208	1	CHMP2A	19	59063429	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5	59063429	65554	481	26149	128	2								
MAVS	57506	broad.mit.edu	37	chr20	3838392	3838392	+	Silent	SNP	G	G	A													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gagtacttcattgcggcactGaggggctgtgagctagttga							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3838392G>A	uc002wjw.3	+	3	397	c.228G>A	c.(226-228)CTG>CTA	p.L76L	MAVS_uc002wjv.2_Silent_p.L76L|MAVS_uc010zqn.1_Silent_p.L76L|MAVS_uc002wjx.3_Intron|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	76	Cytoplasmic (Probable).|Required for interaction with NLRX1.|CARD.				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						TTGCGGCACTGAGGGGCTGTG	0.637													0	0	0	0.013537	0	13	112										A	3838392	G	A	3838392	2	1	87	1	0	0	0	0	0	0	0	1	9338	1277	45	1		1	MAVS	20	3838392	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		3838392	59187128	482	26150	129	2								
MAVS	57506	broad.mit.edu	37	chr20	3838402	3838402	+	Missense_Mutation	SNP	G	G	A													0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttgcggcactgaggggctgtGagctagttgatctcgcggac							TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3838402G>A	uc002wjw.3	+	3	407	c.238G>A	c.(238-240)GAG>AAG	p.E80K	MAVS_uc002wjv.2_Missense_Mutation_p.E80K|MAVS_uc010zqn.1_Missense_Mutation_p.E80K|MAVS_uc002wjx.3_Intron|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	80	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GAGGGGCTGTGAGCTAGTTGA	0.632													0	0	0	0.001855	0	13	109										A	3838402	G	A	3838402	3	1	87	1	0	0	0	0	1	0	0	0	9338	1291	45	1	244	1	MAVS	20	3838402	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	10	3838402	59187118	483	26151	129	2								
MAVS	57506	broad.mit.edu	37	chr20	3842053	3842053	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ggccagggccccccacacctGctgcggcccacagcatcccc	10	22	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3842053G>A	uc002wjw.3	+	4	536	c.367G>A	c.(367-369)GCT>ACT	p.A123T	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_5'UTR|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	123	Pro-rich.|Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CCCCACACCTGCTGCGGCCCA	0.627													0	0	0	0.013537	0	12	100										A	3842053	G	A	3842053	3	1	87	1	0	0	0	0	1	0	0	0	9338	1319	46	2	377	2	MAVS	20	3842053	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3651	3842053	59183467	484	26152										
MAVS	57506	broad.mit.edu	37	chr20	3842137	3842137	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tccaggagacccaggcgccaGagtccccaggagaggtctgt	14	13	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3842137G>C	uc002wjw.3	+	4	620	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_Missense_Mutation_p.E10Q|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	151	Pro-rich.|Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CCAGGCGCCAGAGTCCCCAGG	0.592													0	0	0	0.001984	0	6	65										C	3842137	G	C	3842137	3	2	87	1	0	0	0	0	1	0	0	0	9338	943	33	1	461	1	MAVS	20	3842137	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	84	3842137	59183383	485	26153										
PANK2	80025	broad.mit.edu	37	chr20	3869936	3869936	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cctcctcgagttagggagccGactggacgcgaggcctttgg	15	12	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3869936G>A	uc002wkc.2	+	1	195	c.189G>A	c.(187-189)CCG>CCA	p.P63P	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	63					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TTAGGGAGCCGACTGGACGCG	0.692													0	0	0	0.004672	0	3	5										A	3869936	G	A	3869936	2	1	87	1	0	0	0	0	0	0	0	1	11417	1045	37	1		1	PANK2	20	3869936	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	27799	3869936	59155584	486	26154										
PLCB4	5332	broad.mit.edu	37	chr20	9459591	9459591	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggagatgcagcagatggtGaaattggaagccgagatgga	16	4	0	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:9459591G>A	uc002wnf.2	+	37	3619	c.3483G>A	c.(3481-3483)GTG>GTA	p.V1161V	PLCB4_uc010gbx.2_Silent_p.V1173V|PLCB4_uc002wne.2_Missense_Mutation_p.E1174K|PLCB4_uc002wnh.2_Silent_p.V1008V	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	1161					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AGCAGATGGTGAAATTGGAAG	0.458													0	0	0	0.00308	0	8	36										A	9459591	G	A	9459591	2	1	87	1	0	0	0	0	0	0	0	1	12030	1291	45	1		1	PLCB4	20	9459591	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5589655	9459591	53565929	487	26155										
SNAP25	6616	broad.mit.edu	37	chr20	10279959	10279959	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgaaatggatgaaaacctaGagcaggtgagcggcatcatc	12	7	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:10279959G>C	uc002wnq.1	+	7	663	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	SNAP25_uc002wnr.1_Missense_Mutation_p.E151Q|SNAP25_uc002wns.1_Missense_Mutation_p.E88Q|SNAP25_uc010gca.1_Missense_Mutation_p.E151Q|SNAP25_uc010gcb.1_Missense_Mutation_p.E88Q|SNAP25_uc010gcc.1_Missense_Mutation_p.E45Q	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	151	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	TGAAAACCTAGAGCAGGTGAG	0.468													0	0	0	0.01441	0	51	167										C	10279959	G	C	10279959	3	2	87	1	0	0	0	0	1	0	0	0	14830	943	33	1	595	1	SNAP25	20	10279959	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	820368	10279959	52745561	488	26156										
TASP1	55617	broad.mit.edu	37	chr20	13514765	13514765	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acaaccacagcgcctaccgtGtccaaagtgcctgagtcatt	8	14	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:13514765G>A	uc002woi.2	-	9	816	c.699C>T	c.(697-699)GAC>GAT	p.D233D	TASP1_uc010zri.1_Intron|TASP1_uc002woh.2_Silent_p.D210D|TASP1_uc010zrj.1_RNA	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	233				D->A: 0.1% enzymatic activity; no intramolecular processing.	asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						CGCCTACCGTGTCCAAAGTGC	0.512													0	0	0	0.003755	0	35	109										A	13514765	G	A	13514765	2	1	87	1	0	0	0	0	0	0	0	1	15586	1368	48	2		2	TASP1	20	13514765	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3234806	13514765	49510755	489	26157										
ZNF133	7692	broad.mit.edu	37	chr20	18297183	18297183	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	actgggctttggcaataagtCagctctaattacacacaagc	8	10	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:18297183C>G	uc010gcq.2	+	5	1993	c.1688C>G	c.(1687-1689)TCA>TGA	p.S563*	ZNF133_uc010zrv.1_Nonsense_Mutation_p.S566*|ZNF133_uc010zrw.1_Nonsense_Mutation_p.S500*|ZNF133_uc010gcr.2_Nonsense_Mutation_p.S563*|ZNF133_uc010zrx.1_Nonsense_Mutation_p.S468*|ZNF133_uc002wql.3_Nonsense_Mutation_p.S562*|ZNF133_uc010gcs.2_Nonsense_Mutation_p.S562*|ZNF133_uc010zry.1_Nonsense_Mutation_p.S468*|ZNF133_uc002wqm.2_Nonsense_Mutation_p.S563*	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	563	C2H2-type 13.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GGCAATAAGTCAGCTCTAATT	0.542													0	0	0	0.00278	0	23	51										G	18297183	C	G	18297183	4	3	87	1	0	0	0	0	0	1	0	0	17720	838	29	1	1695	1	ZNF133	20	18297183	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4782418	18297183	44728337	490	26158										
MYLK2	85366	broad.mit.edu	37	chr20	30409372	30409372	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aaggaaagaacatcctggcaGagagccagaaggaagtggga	15	6	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:30409372G>A	uc002wwq.2	+	4	706	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	202					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CATCCTGGCAGAGAGCCAGAA	0.597													0	0	0	0.00333	0	26	63										A	30409372	G	A	30409372	3	1	87	1	0	0	0	0	1	0	0	0	10057	943	33	1	614	1	MYLK2	20	30409372	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	12112189	30409372	32616148	491	26159										
TGM2	7052	broad.mit.edu	37	chr20	36793594	36793594	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtgactctgatactcaccctCggccatggtcgggcgggggc	15	13	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:36793594C>T	uc002xhr.2	-	1	107	c.7G>A	c.(7-9)GAG>AAG	p.E3K	TGM2_uc010zvx.1_Missense_Mutation_p.E3K|TGM2_uc010zvy.1_Missense_Mutation_p.E3K|TGM2_uc002xhs.1_Missense_Mutation_p.E3K|TGM2_uc002xht.2_Missense_Mutation_p.E3K|TGM2_uc002xhu.3_Missense_Mutation_p.E3K	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	3					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TACTCACCCTCGGCCATGGTC	0.687													0	0	0	0.010504	0	18	24										T	36793594	C	T	36793594	3	4	87	1	0	0	0	0	1	0	0	0	15827	893	31	1	2140	1	TGM2	20	36793594	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6384222	36793594	26231926	492	26160										
L3MBTL	26013	broad.mit.edu	37	chr20	42144735	42144735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caggcttgccttctacaggaGaagcaagaagaaggaaagga	13	7	1	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:42144735G>C	uc010zwh.1	+	7	760	c.714G>C	c.(712-714)GAG>GAC	p.E238D	L3MBTL_uc010ggk.1_Missense_Mutation_p.E170D|L3MBTL_uc002xkl.2_Missense_Mutation_p.E170D|L3MBTL_uc002xkm.2_Missense_Mutation_p.E170D|L3MBTL_uc010ggl.2_Missense_Mutation_p.E170D	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	170					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TTCTACAGGAGAAGCAAGAAG	0.577													0	0	0	0.001984	0	6	33										C	42144735	G	C	42144735	3	2	87	1	0	0	0	0	1	0	0	0	8591	933	33	1	524	1	L3MBTL	20	42144735	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	5351141	42144735	20880785	493	26161										
WFDC10A	140832	broad.mit.edu	37	chr20	44258532	44258532	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gggaggataccgtgacaagaAgaggatgcagagtaggtgat	17	4	0	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:44258532A>T	uc002xoz.2	+	1	148	c.80A>T	c.(79-81)AAG>ATG	p.K27M	WFDC9_uc002xoy.2_Intron	NM_080753	NP_542791	Q9H1F0	WF10A_HUMAN	WAP four-disulfide core domain 10A precursor	27						extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CGTGACAAGAAGAGGATGCAG	0.587											OREG0025983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	4	40										T	44258532	A	T	44258532	3	4	87	1	0	0	0	0	1	0	0	0	17344	72	3	5	82	5	WFDC10A	20	44258532	Missense_Mutation	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	2113797	44258532	18766988	494	26162										
SLC2A10	81031	broad.mit.edu	37	chr20	45354112	45354112	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgaggcaggcatcaccgtggGcatcctgctctcctatgccc	11	15	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:45354112G>A	uc002xsl.2	+	2	534	c.437G>A	c.(436-438)GGC>GAC	p.G146D		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	146	Helical; Name=5; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				ATCACCGTGGGCATCCTGCTC	0.622													0	0	0	0.010504	0	20	99										A	45354112	G	A	45354112	3	1	87	1	0	0	0	0	1	0	0	0	14539	1203	42	2	443	2	SLC2A10	20	45354112	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1095580	45354112	17671408	495	26163										
MOCS3	27304	broad.mit.edu	37	chr20	49576560	49576560	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	actcttaaaagaagcaatctGggaagagaagcagggcacac	11	8	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:49576560G>A	uc002xvy.1	+	1	1198	c.1181G>A	c.(1180-1182)TGG>TAG	p.W394*	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	394	Rhodanese.				enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GAAGCAATCTGGGAAGAGAAG	0.498													0	0	0	0.01441	0	91	135										A	49576560	G	A	49576560	4	1	87	1	0	0	0	0	0	1	0	0	9692	1357	47	2	1183	2	MOCS3	20	49576560	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4222448	49576560	13448960	496	26164										
GATA5	140628	broad.mit.edu	37	chr20	61040029	61040029	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtggccgggggcaagagagtCatcctcctggccagaggcct	16	12	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:61040029C>A	uc002ycx.1	-	7	1119	c.1057G>T	c.(1057-1059)GAC>TAC	p.D353Y		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	353					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GCAAGAGAGTCATCCTCCTGG	0.672													1	0	6.72482e-11	0.003163	7.17166e-11	14	24										A	61040029	C	A	61040029	3	1	87	1	0	0	0	0	1	0	0	0	6257	826	29	3	140	3	GATA5	20	61040029	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	11463469	61040029	1985491	497	26165										
PRIC285	85441	broad.mit.edu	37	chr20	62194088	62194088	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcaacattcaggccagggccGaggctgctgggcccagggcg	16	13	2	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:62194088G>A	uc002yfm.2	-	9	6979	c.6087C>T	c.(6085-6087)CTC>CTT	p.L2029L	PRIC285_uc002yfl.1_Silent_p.L1460L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2029					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGCCAGGGCCGAGGCTGCTGG	0.697													0	0	0	0.000602	0	5	6										A	62194088	G	A	62194088	2	1	87	1	0	0	0	0	0	0	0	1	12485	1045	37	1		1	PRIC285	20	62194088	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1154059	62194088	831432	498	26166										
ATP5J	522	broad.mit.edu	37	chr21	27101968	27101968	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttagatttgtattctctaatCttgtccacaaagagtttctg	6	7	3	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:27101968C>A	uc002yls.2	-	2	811	c.138G>T	c.(136-138)AAG>AAT	p.K46N	ATP5J_uc002ylt.2_Missense_Mutation_p.K46N|ATP5J_uc002ylu.2_Missense_Mutation_p.K46N|ATP5J_uc002ylv.2_Missense_Mutation_p.K54N|ATP5J_uc002ylw.2_Missense_Mutation_p.K46N	NM_001685	NP_001676	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	46					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity				0						ATTCTCTAATCTTGTCCACAA	0.348													1	0	0.00024832	0.009096	0.000253452	4	25										A	27101968	C	A	27101968	3	1	87	1	0	0	0	0	1	0	0	0	1158	912	32	3	200	3	ATP5J	21	27101968	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		27101968	21027927	499	26167										
SFRS15	57466	broad.mit.edu	37	chr21	33069036	33069036	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttccacagcttctggctcatCatcatagtcaaatctatcaa	4	12	7	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:33069036C>T	uc002ypd.2	-	8	1231	c.805G>A	c.(805-807)GAT>AAT	p.D269N	SFRS15_uc002ype.2_Missense_Mutation_p.D269N|SFRS15_uc010glu.2_Missense_Mutation_p.D254N|SFRS15_uc002ypf.1_5'UTR	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	269						nucleus	nucleotide binding|RNA binding				0						TCTGGCTCATCATCATAGTCA	0.423													0	0	0	0.006122	0	17	95										T	33069036	C	T	33069036	3	4	87	1	0	0	0	0	1	0	0	0	14171	826	29	1	2690	1	SFRS15	21	33069036	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	5967068	33069036	15060859	500	26168										
GCFC1	94104	broad.mit.edu	37	chr21	34134491	34134491	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcatcgtcatcttcatcatCactggcatcattctcatctt	3	14	9	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:34134491C>T	uc002yqn.2	-	4	977	c.787G>A	c.(787-789)GAT>AAT	p.D263N	GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D263N|GCFC1_uc002yqr.2_Missense_Mutation_p.D263N	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	263						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TCTTCATCATCACTGGCATCA	0.403													0	0	0	0.006214	0	8	105										T	34134491	C	T	34134491	3	4	87	1	0	0	0	0	1	0	0	0	6289	826	29	1	2144	1	GCFC1	21	34134491	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1065455	34134491	13995404	501	26169										
MX2	4600	broad.mit.edu	37	chr21	42762521	42762521	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctcatcaagaagtacatccaGaggcagcagacgatcaactt	8	11	3	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:42762521G>A	uc002yzf.1	+	6	866	c.762G>A	c.(760-762)CAG>CAA	p.Q254Q	MX2_uc011aer.1_Intron|MX2_uc002yzg.1_5'UTR	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	254					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGTACATCCAGAGGCAGCAGA	0.557													0	0	0	0.006999	0	38	111										A	42762521	G	A	42762521	2	1	87	1	0	0	0	0	0	0	0	1	9998	933	33	1		1	MX2	21	42762521	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	8628030	42762521	5367374	502	26170										
DGCR2	9993	broad.mit.edu	37	chr22	19044633	19044633	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgtcgttctcagacatggccGaggcaaagatggggtctggg	16	8	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:19044633G>A	uc002zoq.1	-	6	916	c.668C>T	c.(667-669)TCG>TTG	p.S223L	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Missense_Mutation_p.S179L	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	223	Extracellular (Potential).|C-type lectin.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					AGACATGGCCGAGGCAAAGAT	0.592													0	0	0	0.009096	0	4	13										A	19044633	G	A	19044633	3	1	87	1	0	0	0	0	1	0	0	0	4461	1059	37	1	1004	1	DGCR2	22	19044633	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08		19044633	32259933	503	26171										
CDC45	8318	broad.mit.edu	37	chr22	19470241	19470241	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ttttattctcataaactgtgGagctaatgtagacctattgg	8	6	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:19470241G>C	uc002zpr.2	+	4	309	c.233G>C	c.(232-234)GGA>GCA	p.G78A	CDC45_uc011agz.1_Missense_Mutation_p.G73A|CDC45_uc011aha.1_Missense_Mutation_p.G78A|CDC45_uc002zps.2_Missense_Mutation_p.G78A|CDC45_uc002zpt.2_Intron	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	78					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						ATAAACTGTGGAGCTAATGTA	0.373													0	0	0	0.004482	0	8	132										C	19470241	G	C	19470241	3	2	87	1	0	0	0	0	1	0	0	0	3081	1174	41	1	247	1	CDC45	22	19470241	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	425608	19470241	31834325	504	26172										
ZNF280A	129025	broad.mit.edu	37	chr22	22869392	22869392	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagctaaagaaggtacccctGggattccatccctgagttta	9	11	0	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:22869392G>A	uc002zwe.2	-	2	816	c.563C>T	c.(562-564)CCA>CTA	p.P188L	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGGTACCCCTGGGATTCCATC	0.448													0	0	0	0.00245	0	13	141										A	22869392	G	A	22869392	3	1	87	1	0	0	0	0	1	0	0	0	17811	1348	47	2	1069	2	ZNF280A	22	22869392	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3399151	22869392	28435174	505	26173										
SMARCB1	6598	broad.mit.edu	37	chr22	24129380	24129380	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgatgatggcgctgagcaaGaccttcgggcagaagcccgt	14	10	0	5			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:24129380G>C	uc002zyb.2	+	1	231	c.24G>C	c.(22-24)AAG>AAC	p.K8N	SMARCB1_uc002zyg.2_Missense_Mutation_p.K8N|SMARCB1_uc011ajb.1_Missense_Mutation_p.K8N|SMARCB1_uc002zya.2_Missense_Mutation_p.K8N|SMARCB1_uc002zyc.2_Missense_Mutation_p.K8N|SMARCB1_uc002zyd.2_Missense_Mutation_p.K8N	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	8					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				CGCTGAGCAAGACCTTCGGGC	0.682			D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				0	0	0	0.008291	0	11	38										C	24129380	G	C	24129380	3	2	87	1	0	0	0	0	1	0	0	0	14774	933	33	1	26	1	SMARCB1	22	24129380	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	1259988	24129380	27175186	506	26174										
GGT5	2687	broad.mit.edu	37	chr22	24622208	24622208	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cggatgagctgggccagggtCtcccccagcaggtcccggga	16	14	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:24622208C>T	uc002zzo.3	-	8	1482	c.1065G>A	c.(1063-1065)GAG>GAA	p.E355E	GGT5_uc002zzp.3_Silent_p.E355E|GGT5_uc002zzr.3_Silent_p.E323E|GGT5_uc002zzq.3_Silent_p.E323E|GGT5_uc011ajm.1_Silent_p.E278E|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	355	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						GGGCCAGGGTCTCCCCCAGCA	0.677													0	0	0	0.001168	0	6	27										T	24622208	C	T	24622208	2	4	87	1	0	0	0	0	0	0	0	1	6362	912	32	1		1	GGT5	22	24622208	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	492828	24622208	26682358	507	26175										
SF3A1	10291	broad.mit.edu	37	chr22	30735229	30735229	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caactgcttcaagctgctctCaatatccagacctgtacagt	6	13	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:30735229C>G	uc003ahl.2	-	10	1519	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	463					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						AAGCTGCTCTCAATATCCAGA	0.493													0	0	0	0.008291	0	9	132										G	30735229	C	G	30735229	3	3	87	1	0	0	0	0	1	0	0	0	14146	835	29	1	1022	1	SF3A1	22	30735229	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6113021	30735229	20569337	508	26176										
DRG1	4733	broad.mit.edu	37	chr22	31796663	31796663	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	acttagggctgcttaaggctCgtcttgctaagcttcgtcga	11	10	1	0	rs28369552		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:31796663C>T	uc003aku.2	+	2	231	c.100C>T	c.(100-102)CGT>TGT	p.R34C		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	34					multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1						GCTTAAGGCTCGTCTTGCTAA	0.458													0	0	0	0.003755	0	33	50										T	31796663	C	T	31796663	3	4	87	1	0	0	0	0	1	0	0	0	4761	884	31	1	106	1	DRG1	22	31796663	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1061434	31796663	19507903	509	26177										
APOL1	8542	broad.mit.edu	37	chr22	36661254	36661254	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttgcaagacaaatgatcatGaaagacaaaaactggcacga	8	8	1	4			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:36661254G>A	uc003apf.2	+	6	540	c.372G>A	c.(370-372)ATG>ATA	p.M124I	APOL1_uc011amn.1_Missense_Mutation_p.M1I|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.M140I|APOL1_uc011amo.1_Missense_Mutation_p.M1I|APOL1_uc011amp.1_Missense_Mutation_p.M124I|APOL1_uc011amq.1_Missense_Mutation_p.M106I|APOL1_uc010gwx.2_Missense_Mutation_p.M1I	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	124					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						AAATGATCATGAAAGACAAAA	0.413													0	0	0	0.012319	0	21	68										A	36661254	G	A	36661254	3	1	87	1	0	0	0	0	1	0	0	0	805	1290	45	1	442	1	APOL1	22	36661254	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	4864591	36661254	14643312	510	26178										
MYH9	4627	broad.mit.edu	37	chr22	36696992	36696992	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctctaggtcatggcagatctCttctaattcctgcttcttgg	8	11	5	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:36696992C>T	uc003apg.2	-	22	2974	c.2743G>A	c.(2743-2745)GAG>AAG	p.E915K	MYH9_uc003aph.1_Missense_Mutation_p.E779K	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	915	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGCAGATCTCTTCTAATTCC	0.607			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.01441	0	54	76										T	36696992	C	T	36696992	3	4	87	1	0	0	0	0	1	0	0	0	10042	922	32	1	3219	1	MYH9	22	36696992	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	35738	36696992	14607574	511	26179										
DMC1	11144	broad.mit.edu	37	chr22	38916075	38916075	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agttattgcgaaggtggcttCattttcaggcatctcaggac	11	8	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:38916075C>T	uc003avz.1	-	14	1148	c.973G>A	c.(973-975)GAA>AAA	p.E325K	DMC1_uc011anv.1_Missense_Mutation_p.E270K	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	325					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					AAGGTGGCTTCATTTTCAGGC	0.393								Homologous_recombination					0	0	0	0.003954	0	21	73										T	38916075	C	T	38916075	3	4	87	1	0	0	0	0	1	0	0	0	4579	835	29	1	53	1	DMC1	22	38916075	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2219083	38916075	12388491	512	26180										
ENTHD1	150350	broad.mit.edu	37	chr22	40139834	40139834	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tcttcatgtaatctagcgatCgcacgttttacctcccttaa	5	12	3	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:40139834C>T	uc003ayg.2	-	7	1925	c.1674G>A	c.(1672-1674)GCG>GCA	p.A558A		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	558	Potential.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					ATCTAGCGATCGCACGTTTTA	0.413													0	0	0	0.00308	0	7	60										T	40139834	C	T	40139834	2	4	87	1	0	0	0	0	0	0	0	1	5137	871	31	1		1	ENTHD1	22	40139834	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1223759	40139834	11164732	513	26181										
CELSR1	9620	broad.mit.edu	37	chr22	46930167	46930167	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccccgatccacagccagagcCcaaaggttgtacacggccac	9	17	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:46930167C>A	uc003bhw.1	-	1	2901	c.2901G>T	c.(2899-2901)TGG>TGT	p.W967C		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	967	Extracellular (Potential).|Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CAGCCAGAGCCCAAAGGTTGT	0.597													1	0	5.26018e-13	0.012319	5.66616e-13	20	19										A	46930167	C	A	46930167	3	1	87	1	0	0	0	0	1	0	0	0	3221	624	22	4	6283	4	CELSR1	22	46930167	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	6790333	46930167	4374399	514	26182										
BMX	660	broad.mit.edu	37	chrX	15540529	15540529	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	caccatcttcaagtaccactCtagcccaatatgacaacgaa	4	14	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:15540529C>T	uc004cww.2	+	7	759	c.571C>T	c.(571-573)CTA>TTA	p.L191L	BMX_uc004cwx.3_Silent_p.L191L|BMX_uc004cwy.3_Silent_p.L191L	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	191					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AAGTACCACTCTAGCCCAATA	0.428													0	0	0	0.01441	0	82	24										T	15540529	C	T	15540529	2	4	87	1	0	0	0	0	0	0	0	1	1473	912	32	1		1	BMX	23	15540529	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08		15540529	139730031	515	26183										
PORCN	64840	broad.mit.edu	37	chrX	48372644	48372644	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ccaggtggctgcgagcctacGagagtgctgtctccttccac	12	14	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:48372644G>A	uc010nie.1	+	9	894	c.736G>A	c.(736-738)GAG>AAG	p.E246K	PORCN_uc004djr.1_Missense_Mutation_p.E241K|PORCN_uc004djs.1_Missense_Mutation_p.E235K|PORCN_uc004djt.1_Missense_Mutation_p.E164K|PORCN_uc011mlx.1_Missense_Mutation_p.E164K|PORCN_uc004dju.1_Missense_Mutation_p.E104K|PORCN_uc004djv.1_Missense_Mutation_p.E246K|PORCN_uc004djw.1_Missense_Mutation_p.E240K	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	246	Extracellular (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						GCGAGCCTACGAGAGTGCTGT	0.597													0	0	0	0.012319	0	19	44										A	48372644	G	A	48372644	3	1	87	1	0	0	0	0	1	0	0	0	12258	1059	37	1	766	1	PORCN	23	48372644	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	32832115	48372644	106897916	516	26184										
GPR173	54328	broad.mit.edu	37	chrX	53106308	53106308	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgggcacctacaagtttattCgggaggaggaccagtgcatc	13	9	0	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:53106308C>T	uc004dru.2	+	2	763	c.505C>T	c.(505-507)CGG>TGG	p.R169W		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	169	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CAAGTTTATTCGGGAGGAGGA	0.562													0	0	0	0.001984	0	6	12										T	53106308	C	T	53106308	3	4	87	1	0	0	0	0	1	0	0	0	6671	875	31	1	507	1	GPR173	23	53106308	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	4733664	53106308	102164252	517	26185										
MAGEH1	28986	broad.mit.edu	37	chrX	55479335	55479335	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gaatcgagcaaactgaaagtCatgcattttgtggcaagggt	12	6	1	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:55479335C>T	uc004dum.2	+	1	798	c.528C>T	c.(526-528)GTC>GTT	p.V176V		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	176	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AACTGAAAGTCATGCATTTTG	0.512													0	0	0	0.009718	0	43	15										T	55479335	C	T	55479335	2	4	87	1	0	0	0	0	0	0	0	1	9188	813	29	1		1	MAGEH1	23	55479335	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	2373027	55479335	99791225	518	26186										
SPIN2A	54466	broad.mit.edu	37	chrX	57162619	57162619	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cttagaaccatgctctccctCaaacatgtgttccactgctt	5	14	2	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:57162619C>G	uc004dvb.2	-	2	783	c.412G>C	c.(412-414)GAG>CAG	p.E138Q		NM_019003	NP_061876	Q99865	SPI2A_HUMAN	spindlin family, member 2	138					cell cycle|gamete generation						0						TGCTCTCCCTCAAACATGTGT	0.418													0	0	0	0.00623	0	38	103										G	57162619	C	G	57162619	3	3	87	1	0	0	0	0	1	0	0	0	15052	835	29	1	368	1	SPIN2A	23	57162619	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1683284	57162619	98107941	519	26187										
MTMR8	55613	broad.mit.edu	37	chrX	63488550	63488550	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cagagatgccagtggcctcaGagatgtccatggccccacag	12	13	1	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:63488550G>A	uc004dvs.2	-	14	2050	c.1982C>T	c.(1981-1983)TCT>TTT	p.S661F	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	661						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AGTGGCCTCAGAGATGTCCAT	0.567													0	0	0	0.009096	0	4	32										A	63488550	G	A	63488550	3	1	87	1	0	0	0	0	1	0	0	0	9949	942	33	1	136	1	MTMR8	23	63488550	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6325931	63488550	91782010	520	26188										
TAF7L	54457	broad.mit.edu	37	chrX	100542501	100542501	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tataaactggttctcaacttCatcaggaacttcatcctggc	6	11	4	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:100542501C>T	uc004ehb.2	-	2	301	c.289G>A	c.(289-291)GAA>AAA	p.E97K	TAF7L_uc004eha.2_Missense_Mutation_p.E11K|TAF7L_uc004ehc.1_Missense_Mutation_p.E11K	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	97					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						TTCTCAACTTCATCAGGAACT	0.348													0	0	0	0.009096	0	4	31										T	100542501	C	T	100542501	3	4	87	1	0	0	0	0	1	0	0	0	15530	835	29	1	1147	1	TAF7L	23	100542501	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	37053951	100542501	54728059	521	26189										
BHLHB9	80823	broad.mit.edu	37	chrX	102004757	102004757	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cgctcatgctcacagcctatCcctgagtgtcgttttgattc	8	13	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:102004757C>T	uc010nog.2	+	4	1405	c.834C>T	c.(832-834)ATC>ATT	p.I278I	BHLHB9_uc011mrq.1_Silent_p.I278I|BHLHB9_uc011mrr.1_Silent_p.I278I|BHLHB9_uc011mrs.1_Silent_p.I278I|BHLHB9_uc011mrt.1_Silent_p.I278I|BHLHB9_uc004ejo.2_Silent_p.I278I|BHLHB9_uc011mru.1_Silent_p.I278I|BHLHB9_uc011mrv.1_Silent_p.I278I	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	278						cytoplasm|nucleus	binding			ovary(2)	2						CACAGCCTATCCCTGAGTGTC	0.483													0	0	0	0.014323	0	20	53										T	102004757	C	T	102004757	2	4	87	1	0	0	0	0	0	0	0	1	1420	845	30	1		1	BHLHB9	23	102004757	Silent	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	1462256	102004757	53265803	522	26190										
SERPINA7	6906	broad.mit.edu	37	chrX	105281031	105281031	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	cccaagtaccaagagaaccaGatacaggaatggtgacattt	9	9	0	3			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:105281031G>A	uc004eme.1	-	1	35	c.19C>T	c.(19-21)CTG>TTG	p.L7L	SERPINA7_uc010npd.2_Silent_p.L7L|SERPINA7_uc010npe.1_Silent_p.L7L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	7					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	AAGAGAACCAGATACAGGAAT	0.458													0	0	0	0.00308	0	7	59										A	105281031	G	A	105281031	2	1	87	1	0	0	0	0	0	0	0	1	14094	933	33	1		1	SERPINA7	23	105281031	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	3276274	105281031	49989529	523	26191										
TBC1D8B	54885	broad.mit.edu	37	chrX	106066677	106066677	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	atgacccagtcctttataatCctctacagatcaccaaaagg	5	12	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:106066677C>G	uc004emo.2	+	5	973	c.808C>G	c.(808-810)CCT>GCT	p.P270A	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emm.2_Missense_Mutation_p.P270A|TBC1D8B_uc004emn.2_Missense_Mutation_p.P270A	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	270						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCTTTATAATCCTCTACAGAT	0.313													0	0	0	0.01441	0	55	21										G	106066677	C	G	106066677	3	3	87	1	0	0	0	0	1	0	0	0	15623	855	30	1	826	1	TBC1D8B	23	106066677	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	785646	106066677	49203883	524	26192										
VSIG1	340547	broad.mit.edu	37	chrX	107319443	107319443	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	aattctaagaccatcgcggaActtgagtaagccttcatttt	7	9	2	2			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:107319443A>G	uc004eno.2	+	6	986	c.825A>G	c.(823-825)GAA>GAG	p.E275E	VSIG1_uc011msk.1_Silent_p.E311E	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	275	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCATCGCGGAACTTGAGTAAG	0.403													0	0	0	0.01441	0	47	18										G	107319443	A	G	107319443	2	3	87	1	0	0	0	0	0	0	0	1	17219	40	2	5		5	VSIG1	23	107319443	Silent	SNP	A	TCGA-FD-A3SS-01A-12D-A22Z-08	1252766	107319443	47951117	525	26193										
GLUD2	2747	broad.mit.edu	37	chrX	120181908	120181908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	gtctctccttccccatccggCgcgacgacggctcctgggag	12	17	1	0			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:120181908C>T	uc004eto.2	+	1	447	c.370C>T	c.(370-372)CGC>TGC	p.R124C		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	124					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCCCATCCGGCGCGACGACGG	0.642													0	0	0	0.00499	0	18	24										T	120181908	C	T	120181908	3	4	87	1	0	0	0	0	1	0	0	0	6477	768	27	2	372	2	GLUD2	23	120181908	Missense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	12862465	120181908	35088652	526	26194										
SMARCA1	6594	broad.mit.edu	37	chrX	128599886	128599886	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tgcttctccacgttcaatttGagccataattttctcaatgt	5	10	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:128599886G>C	uc004eun.3	-	22	2865	c.2752C>G	c.(2752-2754)CAA>GAA	p.Q918E	SMARCA1_uc004eup.3_Missense_Mutation_p.Q906E|SMARCA1_uc011muk.1_Missense_Mutation_p.Q918E|SMARCA1_uc011mul.1_Missense_Mutation_p.Q906E	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	918					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						CGTTCAATTTGAGCCATAATT	0.328													0	0	0	0.004007	0	16	58										C	128599886	G	C	128599886	3	2	87	1	0	0	0	0	1	0	0	0	14768	1299	45	1	424	1	SMARCA1	23	128599886	Missense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	8417978	128599886	26670674	527	26195										
HTATSF1	27336	broad.mit.edu	37	chrX	135593696	135593696	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	agttagaagaaaatgactctGaaaactccgaatttgaagat	8	5	1	6			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:135593696G>T	uc004ezw.2	+	10	2214	c.1792G>T	c.(1792-1794)GAA>TAA	p.E598*	HTATSF1_uc004ezx.2_Nonsense_Mutation_p.E598*	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	598	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAATGACTCTGAAAACTCCGA	0.388													1	0	8.58068e-18	0.007291	9.33695e-18	29	50										T	135593696	G	T	135593696	4	4	87	1	0	0	0	0	0	1	0	0	7433	1291	45	3	1826	3	HTATSF1	23	135593696	Nonsense_Mutation	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	6993810	135593696	19676864	528	26196										
L1CAM	3897	broad.mit.edu	37	chrX	153135920	153135920	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	ctgctggagttggtggggaaGagcaggcgcggcttcctgtc	18	9	0	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153135920G>A	uc004fjb.2	-	7	837	c.729C>T	c.(727-729)CTC>CTT	p.L243L	L1CAM_uc004fjc.2_Silent_p.L243L|L1CAM_uc010nuo.2_Silent_p.L238L|L1CAM_uc004fjd.1_Silent_p.L57L|L1CAM_uc004fje.1_Silent_p.L238L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	243	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGTGGGGAAGAGCAGGCGCG	0.602													0	0	0	0.009096	0	4	20										A	153135920	G	A	153135920	2	1	87	1	0	0	0	0	0	0	0	1	8588	929	33	1		1	L1CAM	23	153135920	Silent	SNP	G	TCGA-FD-A3SS-01A-12D-A22Z-08	17542224	153135920	2134640	529	26197										
TKTL1	8277	broad.mit.edu	37	chrX	153557916	153557916	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.568181818181818	300	1.94404994076488e-118	4.20844265367316	5.23554662885948	3.77365630834889	9.82892557078228e-10	1.41973369355744e-08	229	tctccatggatcctgacattCaggttcattcgctggcagtg	10	11	3	1			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153557916C>T	uc004fkg.2	+	13	1855	c.1669C>T	c.(1669-1671)CAG>TAG	p.Q557*	TKTL1_uc011mzl.1_Nonsense_Mutation_p.Q551*|TKTL1_uc011mzm.1_Nonsense_Mutation_p.Q353*|TKTL1_uc004fkh.2_Nonsense_Mutation_p.Q501*	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	557					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCTGACATTCAGGTTCATTC	0.542													0	0	0	0.00308	0	8	75										T	153557916	C	T	153557916	4	4	87	1	0	0	0	0	0	1	0	0	15932	827	29	1	1719	1	TKTL1	23	153557916	Nonsense_Mutation	SNP	C	TCGA-FD-A3SS-01A-12D-A22Z-08	421996	153557916	1712644	530	26198										
NADK	65220	broad.mit.edu	37	chr1	1685647	1685647	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcggggtggacacgatcactCctgacagggacaggcgcagg	16	11	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:1685647C>T	uc009vkw.2	-	10	1065	c.944G>A	c.(943-945)GGA>GAA	p.G315E	NADK_uc001aic.2_Missense_Mutation_p.G315E|NADK_uc001aid.3_Missense_Mutation_p.G315E|NADK_uc001aie.2_Missense_Mutation_p.G460E|NADK_uc010nyv.1_Missense_Mutation_p.G283E|NADK_uc009vkx.1_3'UTR	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	315					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		CACGATCACTCCTGACAGGGA	0.701													0	0	0	0.027356	0	25	37										T	1685647	C	T	1685647	3	4	88	1	0	0	0	0	1	0	0	0	10137	869	30	1	408	1	NADK	1	1685647	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		1685647	247564974	1	26199										
NPHP4	261734	broad.mit.edu	37	chr1	5926434	5926434	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccaaagcctgtgcacttacgAgtaaatgatgacaaagaagt	9	8	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:5926434A>G	uc001alq.1	-	26	3909	c.3643T>C	c.(3643-3645)TCG>CCG	p.S1215P	NPHP4_uc001alr.1_Missense_Mutation_p.S157P	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	1215					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TGCACTTACGAGTAAATGATG	0.597													0	0	0	0.014758	0	4	21										G	5926434	A	G	5926434	3	3	88	1	0	0	0	0	1	0	0	0	10581	318	11	5	657	5	NPHP4	1	5926434	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	4240787	5926434	243324187	2	26200										
USP48	84196	broad.mit.edu	37	chr1	22033020	22033020	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aacaaatttgggagagaagtCttttgctcgtttgcaatcat	9	6	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:22033020C>G	uc001bfb.2	-	17	2389	c.2151G>C	c.(2149-2151)AAG>AAC	p.K717N	USP48_uc001bfa.2_Missense_Mutation_p.K255N|USP48_uc010odq.1_Missense_Mutation_p.K729N|USP48_uc009vqc.2_Missense_Mutation_p.K651N|USP48_uc001bfc.2_Missense_Mutation_p.K717N|USP48_uc001bfd.1_5'Flank	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	717	DUSP 3.				ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GGAGAGAAGTCTTTTGCTCGT	0.388													0	0	0	0.01441	0	71	143										G	22033020	C	G	22033020	3	3	88	1	0	0	0	0	1	0	0	0	17076	912	32	1	1000	1	USP48	1	22033020	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	16106586	22033020	227217601	3	26201										
HSPG2	3339	broad.mit.edu	37	chr1	22191497	22191497	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggcccggatcaggagctcatCcaggtcggccagtgccatca	13	14	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:22191497C>G	uc001bfj.2	-	36	4505	c.4465G>C	c.(4465-4467)GAT>CAT	p.D1489H	HSPG2_uc009vqd.2_Missense_Mutation_p.D1490H	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1489	Laminin IV type A 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGGAGCTCATCCAGGTCGGCC	0.711													0	0	0	0.014758	0	4	4										G	22191497	C	G	22191497	3	3	88	1	0	0	0	0	1	0	0	0	7430	855	30	1	8958	1	HSPG2	1	22191497	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	158477	22191497	227059124	4	26202										
EPHB2	2048	broad.mit.edu	37	chr1	23111208	23111208	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gacgagagcttctcccaggtGgacctgggtggccgcgtcat	15	12	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:23111208G>A	uc009vqj.1	+	3	595	c.450G>A	c.(448-450)GTG>GTA	p.V150V	EPHB2_uc001bge.2_Silent_p.V150V|EPHB2_uc001bgf.2_Silent_p.V150V|EPHB2_uc010odu.1_Silent_p.V150V	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	150	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TCTCCCAGGTGGACCTGGGTG	0.597									Hereditary_Prostate_Cancer				0	0	0	0.001984	0	6	47										A	23111208	G	A	23111208	2	1	88	1	0	0	0	0	0	0	0	1	5175	1335	47	2		2	EPHB2	1	23111208	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	919711	23111208	226139413	5	26203										
KDM1A	23028	broad.mit.edu	37	chr1	23380296	23380296	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caaagattcagctgacatttGaggctactctccaacaatta	6	10	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:23380296G>A	uc001bgi.2	+	4	843	c.694G>A	c.(694-696)GAG>AAG	p.E232K	KDM1A_uc001bgj.2_Missense_Mutation_p.E252K	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	232	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						GCTGACATTTGAGGCTACTCT	0.333													0	0	0	0.024245	0	13	62										A	23380296	G	A	23380296	3	1	88	1	0	0	0	0	1	0	0	0	8122	1291	45	1	772	1	KDM1A	1	23380296	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	269088	23380296	225870325	6	26204										
RCAN3	11123	broad.mit.edu	37	chr1	24857725	24857725	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	taggaaagatttgaagcactCttcaccatctatgatgacca	7	9	3	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:24857725C>G	uc001bjj.2	+	3	526	c.213C>G	c.(211-213)CTC>CTG	p.L71L	RCAN3_uc009vrd.2_Silent_p.L71L|RCAN3_uc009vre.2_Intron|RCAN3_uc009vrf.2_Silent_p.L71L|RCAN3_uc009vrg.2_Intron	NM_013441	NP_038469	Q9UKA8	RCAN3_HUMAN	Down syndrome critical region gene 1-like 2	71					anatomical structure morphogenesis|calcium-mediated signaling		nucleotide binding|RNA binding|troponin I binding				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00473)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0427)|OV - Ovarian serous cystadenocarcinoma(117;1.13e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;0.000923)|BRCA - Breast invasive adenocarcinoma(304;0.0018)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.00493)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.14)		TTGAAGCACTCTTCACCATCT	0.388													0	0	0	0.024245	0	14	171										G	24857725	C	G	24857725	2	3	88	1	0	0	0	0	0	0	0	1	13170	900	32	1		1	RCAN3	1	24857725	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1477429	24857725	224392896	7	26205										
RHCE	6006	broad.mit.edu	37	chr1	25729100	25729100	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gactcacgttgaagatattaCtgatgaccatcctcagggtg	10	9	2	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:25729100C>T	uc001bkf.2	-	3	559	c.473G>A	c.(472-474)AGT>AAT	p.S158N	RHCE_uc001bkg.2_Missense_Mutation_p.S158N|RHCE_uc001bkh.2_Missense_Mutation_p.S158N|RHCE_uc001bki.2_Missense_Mutation_p.S158N|RHCE_uc001bkj.2_Missense_Mutation_p.S142N	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	158						integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGATATTACTGATGACCAT	0.532													0	0	0	0.021022	0	35	178										T	25729100	C	T	25729100	3	4	88	1	0	0	0	0	1	0	0	0	13325	565	20	2	812	2	RHCE	1	25729100	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	871375	25729100	223521521	8	26206										
MAN1C1	57134	broad.mit.edu	37	chr1	26073233	26073233	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agctgaaggaggagttccagGaggccaaggcctgggtggga	19	7	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:26073233G>T	uc001bkm.2	+	3	1042	c.712G>T	c.(712-714)GAG>TAG	p.E238*	MAN1C1_uc009vry.1_Nonsense_Mutation_p.E58*	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	238	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GGAGTTCCAGGAGGCCAAGGC	0.642													1	0	2.44723e-14	0.024334	2.63928e-14	23	35										T	26073233	G	T	26073233	4	4	88	1	0	0	0	0	0	1	0	0	9213	1175	41	3	722	3	MAN1C1	1	26073233	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	344133	26073233	223177388	9	26207										
ZBTB8A	653121	broad.mit.edu	37	chr1	33058581	33058581	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcctgcagcaactgaacgagCagcgcaggcaagatgtattt	11	10	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:33058581C>T	uc001bvn.2	+	3	534	c.49C>T	c.(49-51)CAG>TAG	p.Q17*	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Nonsense_Mutation_p.Q17*	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGAACGAGCAGCGCAGGCA	0.418													0	0	0	0.021523	0	25	36										T	33058581	C	T	33058581	4	4	88	1	0	0	0	0	0	1	0	0	17553	711	25	2	51	2	ZBTB8A	1	33058581	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6985348	33058581	216192040	10	26208										
YARS	8565	broad.mit.edu	37	chr1	33272134	33272134	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaagggtgctccacctgcttTaccacctcagctccagcctt	7	16	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:33272134T>A	uc001bvy.1	-	4	1247	c.459A>T	c.(457-459)GTA>GTT	p.V153V		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	153			Missing (in CMTDIC).		apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	CCACCTGCTTTACCACCTCAG	0.542													0	0	0	0.009535	0	29	141										A	33272134	T	A	33272134	2	1	88	1	0	0	0	0	0	0	0	1	17464	1741	61	5		5	YARS	1	33272134	Silent	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	213553	33272134	215978487	11	26209										
NT5C1A	84618	broad.mit.edu	37	chr1	40131908	40131908	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gactgcattctgaggcttggGctgcagaggtatgggagaag	17	6	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:40131908G>A	uc001cdq.1	-	2	136	c.136C>T	c.(136-138)CCC>TCC	p.P46S		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	46					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TGAGGCTTGGGCTGCAGAGGT	0.582													0	0	0	0.014758	0	5	93										A	40131908	G	A	40131908	3	1	88	1	0	0	0	0	1	0	0	0	10685	1217	42	2	990	2	NT5C1A	1	40131908	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6859774	40131908	209118713	12	26210										
STIL	6491	broad.mit.edu	37	chr1	47716863	47716863	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catctaagaaggtgcctactGaattcatgctattcatctgc	7	10	4	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:47716863G>A	uc001crc.1	-	17	3964	c.3809C>T	c.(3808-3810)TCA>TTA	p.S1270L	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.S1224L|STIL_uc010omo.1_Missense_Mutation_p.S1253L|STIL_uc001crd.1_Missense_Mutation_p.S1271L|STIL_uc001cre.1_Missense_Mutation_p.S1270L	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1270					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GGTGCCTACTGAATTCATGCT	0.383													0	0	0	0.01441	0	82	70										A	47716863	G	A	47716863	3	1	88	1	0	0	0	0	1	0	0	0	15281	1294	45	1	58	1	STIL	1	47716863	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7584955	47716863	201533758	13	26211										
ZNHIT6	54680	broad.mit.edu	37	chr1	86172186	86172186	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttcttctgtaccacaagtctCacacctacaaaagcccacat	3	15	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:86172186C>G	uc001dlh.2	-	2	795	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	ZNHIT6_uc010osc.1_Missense_Mutation_p.E182Q	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	221	HIT-type.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						CCACAAGTCTCACACCTACAA	0.318													0	0	0	0.01441	0	64	115										G	86172186	C	G	86172186	3	3	88	1	0	0	0	0	1	0	0	0	18206	835	29	1	787	1	ZNHIT6	1	86172186	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	38455323	86172186	163078435	14	26212										
BRDT	676	broad.mit.edu	37	chr1	92441909	92441909	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tatttaagcagcaagaaattCcttctgtatttcctaagaca	5	8	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:92441909C>A	uc001dok.3	+	5	881	c.532C>A	c.(532-534)CCT>ACT	p.P178T	BRDT_uc001dol.3_Missense_Mutation_p.P178T|BRDT_uc010osz.1_Missense_Mutation_p.P182T|BRDT_uc009wdf.2_Missense_Mutation_p.P105T|BRDT_uc010ota.1_Missense_Mutation_p.P132T|BRDT_uc010otb.1_Missense_Mutation_p.P132T|BRDT_uc001dom.3_Missense_Mutation_p.P178T	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GCAAGAAATTCCTTCTGTATT	0.403													1	0	4.36969e-10	0.016723	4.60926e-10	12	83										A	92441909	C	A	92441909	3	1	88	1	0	0	0	0	1	0	0	0	1508	855	30	3	546	3	BRDT	1	92441909	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6269723	92441909	156808712	15	26213										
BCAR3	8412	broad.mit.edu	37	chr1	94027918	94027918	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcacctttgctgccccatagCaatcgcatttgaaattcagt	7	12	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:94027918C>G	uc001dpz.2	-	12	2633	c.2358G>C	c.(2356-2358)TTG>TTC	p.L786F	BCAR3_uc001dqa.2_Missense_Mutation_p.L786F|BCAR3_uc001dqb.2_Missense_Mutation_p.L786F|BCAR3_uc001dpx.3_Missense_Mutation_p.L462F|BCAR3_uc001dpy.2_Missense_Mutation_p.L695F	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	786	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		TGCCCCATAGCAATCGCATTT	0.388													0	0	0	0.01441	0	74	72										G	94027918	C	G	94027918	3	3	88	1	0	0	0	0	1	0	0	0	1349	709	25	4	123	4	BCAR3	1	94027918	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1586009	94027918	155222703	16	26214										
CSF1	1435	broad.mit.edu	37	chr1	110456967	110456967	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcggagtactgtagccacatGattgggagtggacacctgca	13	9	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:110456967G>A	uc001dyu.2	+	2	539	c.126G>A	c.(124-126)ATG>ATA	p.M42I	CSF1_uc001dyt.2_Missense_Mutation_p.M42I|CSF1_uc001dyv.3_Missense_Mutation_p.M42I|CSF1_uc001dyw.3_Missense_Mutation_p.M42I	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	42	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		GTAGCCACATGATTGGGAGTG	0.582													0	0	0	0.013537	0	13	54										A	110456967	G	A	110456967	3	1	88	1	0	0	0	0	1	0	0	0	3931	1290	45	1	132	1	CSF1	1	110456967	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	16429049	110456967	138793654	17	26215										
RAP1A	5906	broad.mit.edu	37	chr1	112246033	112246033	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tagtatattctattacagctCagtccacgtttaacgactta	5	9	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:112246033C>A	uc001ebi.2	+	5	363	c.259C>A	c.(259-261)CAG>AAG	p.Q87K	RAP1A_uc001ebk.2_Missense_Mutation_p.Q87K|RAP1A_uc001ebl.2_Missense_Mutation_p.Q87K|RAP1A_uc001ebm.2_RNA	NM_002884	NP_002875	P62834	RAP1A_HUMAN	RAP1A, member of RAS oncogene family precursor	87					activation of MAPKK activity|blood coagulation|energy reserve metabolic process|nerve growth factor receptor signaling pathway|regulation of insulin secretion	cytosol|plasma membrane	GTP binding|GTPase activity				0		all_cancers(81;6.79e-06)|all_epithelial(167;2.42e-05)|all_lung(203;0.000105)|Lung NSC(277;0.00021)		Lung(183;0.0183)|Colorectal(144;0.0418)|LUSC - Lung squamous cell carcinoma(189;0.0966)|all cancers(265;0.098)|Epithelial(280;0.0981)|COAD - Colon adenocarcinoma(174;0.141)		TATTACAGCTCAGTCCACGTT	0.358													1	0	8.24728e-16	0.024334	8.95473e-16	23	93										A	112246033	C	A	112246033	3	1	88	1	0	0	0	0	1	0	0	0	13035	827	29	3	273	3	RAP1A	1	112246033	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1789066	112246033	137004588	18	26216										
FCGR1B	2210	broad.mit.edu	37	chr1	120930097	120930097	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cgatgctttcccatgcctgaGcaatggtaggtgccattgtg	12	10	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:120930097G>A	uc001eip.2	-	4	554	c.504C>T	c.(502-504)TGC>TGT	p.C168C	FCGR1B_uc001eiq.2_Silent_p.C76C|FCGR1B_uc010oxl.1_RNA|FCGR1B_uc009whr.2_Silent_p.C168C|FCGR1B_uc009whs.2_Silent_p.C169C	NM_001017986	NP_001017986	Q92637	FCGRB_HUMAN	Fc fragment of IgG, high affinity Ib, receptor	168	Extracellular (Potential).|Ig-like C2-type 2.				interferon-gamma-mediated signaling pathway	integral to membrane|plasma membrane	IgG binding|immunoglobulin receptor activity				0	all_neural(166;0.181)	all_lung(203;7.27e-05)|Lung NSC(69;0.000389)|all_epithelial(167;0.068)		Lung(183;0.0327)|LUSC - Lung squamous cell carcinoma(189;0.19)		CCATGCCTGAGCAATGGTAGG	0.408													0	0	0	0.01441	0	37	230										A	120930097	G	A	120930097	2	1	88	1	0	0	0	0	0	0	0	1	5780	963	34	2		2	FCGR1B	1	120930097	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	8684064	120930097	128320524	19	26217										
HORMAD1	84072	broad.mit.edu	37	chr1	150676596	150676596	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaactatcaagtttatacctGagaatgagaaatagaaagat	7	4	1	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:150676596G>A	uc001evk.1	-	12	1052	c.946C>T	c.(946-948)CAG>TAG	p.Q316*	HORMAD1_uc001evl.1_Nonsense_Mutation_p.Q309*|HORMAD1_uc001evm.1_Nonsense_Mutation_p.Q236*	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	316					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GTTTATACCTGAGAATGAGAA	0.299													0	0	0	0.021553	0	5	77										A	150676596	G	A	150676596	4	1	88	1	0	0	0	0	0	1	0	0	7286	1299	45	1	254	1	HORMAD1	1	150676596	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	29746499	150676596	98574025	20	26218										
IVL	3713	broad.mit.edu	37	chr1	152882824	152882824	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcagcaggaggggcagctggAgctcccagagcagcaggagg	19	10	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:152882824A>T	uc001fau.2	+	2	597	c.551A>T	c.(550-552)GAG>GTG	p.E184V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	184	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].|4.				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			gggcagctggagctcccagag	0.055													0	0	0	0.004672	0	3	7										T	152882824	A	T	152882824	3	4	88	1	0	0	0	0	1	0	0	0	7929	304	11	5	553	5	IVL	1	152882824	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	2206228	152882824	96367797	21	26219										
INTS3	65123	broad.mit.edu	37	chr1	153744827	153744827	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cctgcacagcctgaggagctCtagcagcaagctggcccagc	12	15	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153744827C>G	uc009wom.2	+	28	2953	c.2732C>G	c.(2731-2733)TCT>TGT	p.S911C	INTS3_uc001fct.2_Missense_Mutation_p.S911C|INTS3_uc001fcu.2_Missense_Mutation_p.S603C|INTS3_uc001fcv.2_Missense_Mutation_p.S705C|INTS3_uc010peb.1_Missense_Mutation_p.S705C|INTS3_uc001fcw.2_Missense_Mutation_p.S424C|INTS3_uc010pec.1_Missense_Mutation_p.S424C|INTS3_uc001fcy.2_Missense_Mutation_p.S208C|INTS3_uc001fcx.2_Missense_Mutation_p.S208C	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	912					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGAGGAGCTCTAGCAGCAAG	0.592											OREG0013827	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.020292	0	13	101										G	153744827	C	G	153744827	3	3	88	1	0	0	0	0	1	0	0	0	7779	913	32	1	2838	1	INTS3	1	153744827	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	862003	153744827	95505794	22	26220										
DENND4B	9909	broad.mit.edu	37	chr1	153906649	153906649	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccacagtgggctgtgcccctCgggcactgcccaggctacca	12	17	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153906649C>T	uc001fdd.1	-	19	3304	c.2903G>A	c.(2902-2904)CGA>CAA	p.R968Q	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	968										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGTGCCCCTCGGGCACTGCC	0.642													0	0	0	0.009096	0	4	10										T	153906649	C	T	153906649	3	4	88	1	0	0	0	0	1	0	0	0	4434	884	31	1	1627	1	DENND4B	1	153906649	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	161822	153906649	95343972	23	26221										
DENND4B	9909	broad.mit.edu	37	chr1	153910053	153910053	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aggttgctcttgaagagactCaaacaactcagcccgtagct	9	11	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153910053C>G	uc001fdd.1	-	15	2544	c.2143G>C	c.(2143-2145)GAG>CAG	p.E715Q		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	715										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGAAGAGACTCAAACAACTCA	0.607													0	0	0	0.001984	0	7	32										G	153910053	C	G	153910053	3	3	88	1	0	0	0	0	1	0	0	0	4434	835	29	1	2403	1	DENND4B	1	153910053	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3404	153910053	95340568	24	26222										
DENND4B	9909	broad.mit.edu	37	chr1	153910278	153910278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	taaagacagtgagctcacttCctgacagctcctctagctcc	7	14	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:153910278C>T	uc001fdd.1	-	14	2428	c.2027G>A	c.(2026-2028)GGA>GAA	p.G676E		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	676										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAGCTCACTTCCTGACAGCTC	0.542													0	0	0	0.027356	0	28	177										T	153910278	C	T	153910278	3	4	88	1	0	0	0	0	1	0	0	0	4434	855	30	1	2523	1	DENND4B	1	153910278	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	225	153910278	95340343	25	26223										
MEX3A	92312	broad.mit.edu	37	chr1	156047421	156047421	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	actggttcctcgcccctcacCggtgtcttgatgtaggtgtt	11	12	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:156047421C>T	uc001fnd.3	-	2	507	c.507G>A	c.(505-507)CCG>CCA	p.P169P		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	169	KH 1.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					CGCCCCTCACCGGTGTCTTGA	0.587													0	0	0	0.008291	0	10	16										T	156047421	C	T	156047421	2	4	88	1	0	0	0	0	0	0	0	1	9509	639	23	2		2	MEX3A	1	156047421	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2137143	156047421	93203200	26	26224										
IQGAP3	128239	broad.mit.edu	37	chr1	156521553	156521553	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atggtaccgaggggcgacagGgaggctgacatcatctaggc	16	9	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:156521553G>A	uc001fpf.2	-	15	1753	c.1678C>T	c.(1678-1680)CCT>TCT	p.P560S	IQGAP3_uc009wsb.1_Missense_Mutation_p.P517S	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	560					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGCGACAGGGAGGCTGACA	0.572													0	0	0	0.027356	0	25	49										A	156521553	G	A	156521553	3	1	88	1	0	0	0	0	1	0	0	0	7816	1232	43	2	3313	2	IQGAP3	1	156521553	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	474132	156521553	92729068	27	26225										
BAT2L2	23215	broad.mit.edu	37	chr1	171506532	171506532	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctttctgagcctcgtatgctGtgggggtcagatccctatcc	11	12	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:171506532G>A	uc010pmg.1	+	15	2684	c.2418G>A	c.(2416-2418)CTG>CTA	p.L806L	BAT2L2_uc010pmh.1_5'Flank	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	806							protein C-terminus binding				0						CTCGTATGCTGTGGGGGTCAG	0.458													0	0	0	0.014758	0	5	31										A	171506532	G	A	171506532	2	1	88	1	0	0	0	0	0	0	0	1	1321	1364	48	2		2	BAT2L2	1	171506532	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	14984979	171506532	77744089	28	26226										
PIGC	5279	broad.mit.edu	37	chr1	172410895	172410895	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaggaacctggacaagtcttCcttgatttcagcttcatccc	8	12	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:172410895C>T	uc001gil.2	-	2	1149	c.868G>A	c.(868-870)GAA>AAA	p.E290K	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Missense_Mutation_p.E290K|PIGC_uc001gio.2_Missense_Mutation_p.E290K	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	290					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						GACAAGTCTTCCTTGATTTCA	0.388													0	0	0	0.01441	0	49	543										T	172410895	C	T	172410895	3	4	88	1	0	0	0	0	1	0	0	0	11886	864	30	1	29	1	PIGC	1	172410895	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	904363	172410895	76839726	29	26227										
RABGAP1L	9910	broad.mit.edu	37	chr1	174247872	174247872	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatgagcgattttggtatttCagcagaaagactttcacaga	9	6	2	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:174247872C>G	uc001gjx.2	+	10	1473	c.1278C>G	c.(1276-1278)TTC>TTG	p.F426L	RABGAP1L_uc009wwq.1_Missense_Mutation_p.F438L|RABGAP1L_uc001gjw.2_Missense_Mutation_p.F389L|RABGAP1L_uc001gjy.2_Missense_Mutation_p.F94L|RABGAP1L_uc001gjz.2_Missense_Mutation_p.F73L	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	426					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						TTTGGTATTTCAGCAGAAAGA	0.423													0	0	0	0.01441	0	148	320										G	174247872	C	G	174247872	3	3	88	1	0	0	0	0	1	0	0	0	12965	825	29	1	1312	1	RABGAP1L	1	174247872	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1836977	174247872	75002749	30	26228										
FAM129A	116496	broad.mit.edu	37	chr1	184792404	184792404	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agagctctgcattcctccttCaaggcacttaatccttctga	6	13	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:184792404C>G	uc001gra.2	-	8	1076	c.882G>C	c.(880-882)TTG>TTC	p.L294F	FAM129A_uc001grb.1_Missense_Mutation_p.L57F|FAM129A_uc009wyh.1_Missense_Mutation_p.L122F|FAM129A_uc009wyi.1_Missense_Mutation_p.L92F	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	294					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						ATTCCTCCTTCAAGGCACTTA	0.458													0	0	0	0.020292	0	15	242										G	184792404	C	G	184792404	3	3	88	1	0	0	0	0	1	0	0	0	5436	825	29	1	1932	1	FAM129A	1	184792404	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10544532	184792404	64458217	31	26229										
ADORA1	134	broad.mit.edu	37	chr1	203134960	203134960	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccttccttaagatttggaatGaccatttccgctgccagcct	7	13	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:203134960G>A	uc001gze.1	+	4	1346	c.913G>A	c.(913-915)GAC>AAC	p.D305N	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.D305N|ADORA1_uc010pqg.1_Missense_Mutation_p.D237N|ADORA1_uc009xak.1_3'UTR|ADORA1_uc010pqh.1_Missense_Mutation_p.D338N	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	305	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GATTTGGAATGACCATTTCCG	0.572													0	0	0	0.004007	0	16	38										A	203134960	G	A	203134960	3	1	88	1	0	0	0	0	1	0	0	0	326	1290	45	1	919	1	ADORA1	1	203134960	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	18342556	203134960	46115661	32	26230										
PIK3C2B	5287	broad.mit.edu	37	chr1	204412694	204412697	+	Frame_Shift_Del	DEL	ACTG	ACTG	-													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atactggtagcggatgctgaActgagagtccttgaggccgt							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:204412694_204412697delACTG	uc001haw.2	-	20	3375_3378	c.2896_2899delCAGT	c.(2896-2901)CAGTTCfs	p.Q966fs	PIK3C2B_uc010pqv.1_Frame_Shift_Del_p.Q938fs	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	966_967					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CGGATGCTGAACTGAGAGTCCTTG	0.569																		37	254	---	---								-	204412697	ACTG	-	204412694	7	5	88	1	0	1	0	1	0	0	0	0	11910	43	2	0	2065	0	PIK3C2B	1	204412694	Frame_Shift_Del	DEL	ACTG	TCGA-FJ-A3Z7-01A-12D-A23M-08	1277734	204412694	44837927	33	26231										
PLXNA2	5362	broad.mit.edu	37	chr1	208227794	208227794	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgtactgctgatgggacttcGtcatgaactctggcttacac	10	10	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:208227794G>C	uc001hgz.2	-	14	3586	c.2828C>G	c.(2827-2829)ACG>AGG	p.T943R		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	943	Extracellular (Potential).|IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ATGGGACTTCGTCATGAACTC	0.592													0	0	0	0.00499	0	18	55										C	208227794	G	C	208227794	3	2	88	1	0	0	0	0	1	0	0	0	12120	1145	40	4	2932	4	PLXNA2	1	208227794	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3815100	208227794	41022827	34	26232										
USH2A	7399	broad.mit.edu	37	chr1	216348659	216348659	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatacccatttcctatgaaaCggattcctttcatcatcgtg	5	11	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:216348659C>T	uc001hku.1	-	21	4949	c.4562G>A	c.(4561-4563)CGT>CAT	p.R1521H	USH2A_uc001hkv.2_Missense_Mutation_p.R1521H	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1521	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCCTATGAAACGGATTCCTTT	0.428										HNSCC(13;0.011)			0	0	0	0.00499	0	17	48										T	216348659	C	T	216348659	3	4	88	1	0	0	0	0	1	0	0	0	17033	536	19	2	11268	2	USH2A	1	216348659	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	8120865	216348659	32901962	35	26233										
HHIPL2	79802	broad.mit.edu	37	chr1	222696178	222696178	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aagctaaggttgcactggaaGattttctagcagctttctct	9	8	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:222696178G>A	uc001hnh.1	-	9	1998	c.1940C>T	c.(1939-1941)TCT>TTT	p.S647F		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	647					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		TGCACTGGAAGATTTTCTAGC	0.433													0	0	0	0.014323	0	22	150										A	222696178	G	A	222696178	3	1	88	1	0	0	0	0	1	0	0	0	7094	942	33	1	238	1	HHIPL2	1	222696178	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6347519	222696178	26554443	36	26234										
OBSCN	84033	broad.mit.edu	37	chr1	228464926	228464926	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagggcgcctgcaggagcctCaccatttaccggtgcgagtt	13	13	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:228464926C>T	uc009xez.1	+	24	6710	c.6666C>T	c.(6664-6666)CTC>CTT	p.L2222L	OBSCN_uc001hsn.2_Silent_p.L2222L|OBSCN_uc001hsp.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2222	Ig-like 22.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCAGGAGCCTCACCATTTACC	0.637													0	0	0	0.001984	0	6	7										T	228464926	C	T	228464926	2	4	88	1	0	0	0	0	0	0	0	1	10812	813	29	1		1	OBSCN	1	228464926	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5768748	228464926	20785695	37	26235										
OR2C3	81472	broad.mit.edu	37	chr1	247694861	247694861	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	actggagtctctaaatttgcGccagcttgcctgcagagcca	10	12	1	1	rs147306837		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr1:247694861G>A	uc009xgy.2	-	2	1315	c.953C>T	c.(952-954)GCG>GTG	p.A318V	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	318	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CTAAATTTGCGCCAGCTTGCC	0.512													0	0	0	0.004007	0	16	42										A	247694861	G	A	247694861	3	1	88	1	0	0	0	0	1	0	0	0	10993	1087	38	2	13	2	OR2C3	1	247694861	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	19229935	247694861	1555760	38	26236										
NOL10	79954	broad.mit.edu	37	chr2	10799346	10799346	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtcaaggcaccattaaatttCaaagcagagattgttggtaa	9	6	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:10799346C>G	uc002raq.2	-	10	833	c.708G>C	c.(706-708)TTG>TTC	p.L236F	NOL10_uc010yje.1_Missense_Mutation_p.L210F|NOL10_uc010yjf.1_Missense_Mutation_p.L186F|NOL10_uc002rap.2_Missense_Mutation_p.L236F|NOL10_uc002rar.2_Missense_Mutation_p.L86F	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	236	WD 3.					nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		CATTAAATTTCAAAGCAGAGA	0.373													0	0	0	0.001984	0	5	17										G	10799346	C	G	10799346	3	3	88	1	0	0	0	0	1	0	0	0	10520	825	29	1	1406	1	NOL10	2	10799346	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		10799346	232400027	39	26237										
MYCN	4613	broad.mit.edu	37	chr2	16082556	16082556	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggagcggcttctccgcccgcGagaagctggagcgcgccgtg	17	14	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:16082556G>A	uc002rci.2	+	2	670	c.370G>A	c.(370-372)GAG>AAG	p.E124K	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Missense_Mutation_p.E116K	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	124					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CTCCGCCCGCGAGAAGCTGGA	0.642			A		neuroblastoma								0	0	0	0.006122	0	14	14										A	16082556	G	A	16082556	3	1	88	1	0	0	0	0	1	0	0	0	10021	1059	37	1	372	1	MYCN	2	16082556	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5283210	16082556	227116817	40	26238										
HADHA	3030	broad.mit.edu	37	chr2	26437925	26437925	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttaacaatgatactcactttCcaccaatcccttgtctctct	2	14	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:26437925C>G	uc002rgy.2	-	8	926	c.796G>C	c.(796-798)GAA>CAA	p.E266Q	HADHA_uc010yks.1_Missense_Mutation_p.E179Q|HADHA_uc010ykt.1_Missense_Mutation_p.E179Q	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	266					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TACTCACTTTCCACCAATCCC	0.358													0	0	0	0.01441	0	74	146										G	26437925	C	G	26437925	3	3	88	1	0	0	0	0	1	0	0	0	6943	864	30	1	1547	1	HADHA	2	26437925	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10355369	26437925	216761448	41	26239										
TMEM214	54867	broad.mit.edu	37	chr2	27258520	27258520	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atcatccgagggctgctggcGaaggcagcagggtctctgga	16	10	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:27258520G>A	uc002ria.3	+	4	671	c.561G>A	c.(559-561)GCG>GCA	p.A187A	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Intron	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	187						integral to membrane	protein binding				0						GGCTGCTGGCGAAGGCAGCAG	0.562													0	0	0	0.013114	0	48	98										A	27258520	G	A	27258520	2	1	88	1	0	0	0	0	0	0	0	1	16134	1045	37	1		1	TMEM214	2	27258520	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	820595	27258520	215940853	42	26240										
CAD	790	broad.mit.edu	37	chr2	27447627	27447627	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttttaggcaattaaggccctGaaggaggaaaacatccagac	10	8	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:27447627G>A	uc002rji.2	+	10	1431	c.1269G>A	c.(1267-1269)CTG>CTA	p.L423L	CAD_uc010eyw.2_Silent_p.L423L	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	423	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TTAAGGCCCTGAAGGAGGAAA	0.483													0	0	0	0.009718	0	43	212										A	27447627	G	A	27447627	2	1	88	1	0	0	0	0	0	0	0	1	2565	1277	45	1		1	CAD	2	27447627	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	189107	27447627	215751746	43	26241										
C2orf71	388939	broad.mit.edu	37	chr2	29297062	29297062	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cgaattgctttgggctttttCaagaactgaatgccactctt	8	9	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:29297062C>G	uc002rmt.1	-	1	66	c.66G>C	c.(64-66)TTG>TTC	p.L22F		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	22					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						TGGGCTTTTTCAAGAACTGAA	0.493													0	0	0	0.024245	0	15	100										G	29297062	C	G	29297062	3	3	88	1	0	0	0	0	1	0	0	0	2191	825	29	1	3808	1	C2orf71	2	29297062	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1849435	29297062	213902311	44	26242										
CLIP4	79745	broad.mit.edu	37	chr2	29366627	29366627	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tccagacccagtagatatgcCgttagagatggctgacgccg	12	11	0	4	rs138901368	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:29366627C>G	uc002rmv.2	+	7	940	c.701C>G	c.(700-702)CCG>CGG	p.P234R	CLIP4_uc002rmu.2_Missense_Mutation_p.P234R|CLIP4_uc010ezm.1_Missense_Mutation_p.P234R|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Missense_Mutation_p.P216R	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	234										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTAGATATGCCGTTAGAGATG	0.453													0	0	0	0.009535	0	30	145										G	29366627	C	G	29366627	3	3	88	1	0	0	0	0	1	0	0	0	3535	652	23	4	723	4	CLIP4	2	29366627	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	69565	29366627	213832746	45	26243										
CEBPZ	10153	broad.mit.edu	37	chr2	37450318	37450318	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agttgtaaaatataccggatGatcatctagttggcttctta	8	6	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:37450318G>A	uc002rpz.2	-	3	1906	c.1876C>T	c.(1876-1878)CAT>TAT	p.H626Y		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	626					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				TATACCGGATGATCATCTAGT	0.343													0	0	0	0.01441	0	55	65										A	37450318	G	A	37450318	3	1	88	1	0	0	0	0	1	0	0	0	3204	1290	45	1	1344	1	CEBPZ	2	37450318	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	8083691	37450318	205749055	46	26244										
PLEK	5341	broad.mit.edu	37	chr2	68607517	68607517	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tattgttagaagatggaattGaattctataagaagaaaagt	9	1	1	5			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:68607517G>C	uc002sen.3	+	2	262	c.100G>C	c.(100-102)GAA>CAA	p.E34Q	PLEK_uc010fde.2_Missense_Mutation_p.E34Q	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	34	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AGATGGAATTGAATTCTATAA	0.453													0	0	0	0.01441	0	53	47										C	68607517	G	C	68607517	3	2	88	1	0	0	0	0	1	0	0	0	12053	1291	45	1	106	1	PLEK	2	68607517	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	31157199	68607517	174591856	47	26245										
C2orf65	130951	broad.mit.edu	37	chr2	74834257	74834257	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctttgtgacctcaacgacctGaaacctcctgactctggcta	7	14	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:74834257G>A	uc002smy.2	-	4	637	c.520C>T	c.(520-522)CAG>TAG	p.Q174*	C2orf65_uc010ysa.1_Nonsense_Mutation_p.Q174*|C2orf65_uc002smz.2_Nonsense_Mutation_p.Q174*	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	174					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						TCAACGACCTGAAACCTCCTG	0.443													0	0	0	0.01892	0	24	135										A	74834257	G	A	74834257	4	1	88	1	0	0	0	0	0	1	0	0	2184	1299	45	1	1104	1	C2orf65	2	74834257	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6226740	74834257	168365116	48	26246										
C2orf89	129293	broad.mit.edu	37	chr2	85066332	85066332	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cctccaaaagggccttcaccCgcttccctattctctcattc	4	18	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:85066332C>G	uc010ysl.1	-	4	1021	c.932G>C	c.(931-933)CGG>CCG	p.R311P	C2orf89_uc002sou.3_Missense_Mutation_p.R262P|C2orf89_uc002sov.2_RNA|C2orf89_uc010fgc.1_Missense_Mutation_p.R311P	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	311	Extracellular (Potential).					integral to membrane				ovary(1)	1						GGCCTTCACCCGCTTCCCTAT	0.527													0	0	0	0.012319	0	20	52										G	85066332	C	G	85066332	3	3	88	1	0	0	0	0	1	0	0	0	2203	652	23	4	601	4	C2orf89	2	85066332	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10232075	85066332	158133041	49	26247										
ZNF514	84874	broad.mit.edu	37	chr2	95815563	95815563	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttctccagtgtgacatcgctGatggcgcctaagttctgact	10	11	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:95815563G>A	uc002sue.1	-	5	1041	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	ZNF514_uc002sud.1_Nonsense_Mutation_p.Q296*	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	223	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGACATCGCTGATGGCGCCTA	0.438													0	0	0	0.01441	0	48	178										A	95815563	G	A	95815563	4	1	88	1	0	0	0	0	0	1	0	0	17956	1299	45	1	539	1	ZNF514	2	95815563	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	10749231	95815563	147383810	50	26248										
NPAS2	4862	broad.mit.edu	37	chr2	101584864	101584864	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggaactccaagcccgagttCatcgtgtgcacacactcggt	10	13	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:101584864C>T	uc002tap.1	+	11	1315	c.1029C>T	c.(1027-1029)TTC>TTT	p.F343F	NPAS2_uc010yvt.1_Silent_p.F408F	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	343	PAC.				central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						AGCCCGAGTTCATCGTGTGCA	0.612													0	0	0	0.012319	0	19	79										T	101584864	C	T	101584864	2	4	88	1	0	0	0	0	0	0	0	1	10563	825	29	1		1	NPAS2	2	101584864	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5769301	101584864	141614509	51	26249										
IL18RAP	8807	broad.mit.edu	37	chr2	103059778	103059778	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaagtctcagtacctgaggcGaaaaggtaagaaaaaaactc	10	7	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:103059778G>A	uc002tbx.2	+	8	1399	c.915G>A	c.(913-915)GCG>GCA	p.A305A	IL18RAP_uc010fiz.2_Silent_p.A163A	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	305	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						TACCTGAGGCGAAAAGGTAAG	0.408													0	0	0	0.010729	0	9	53										A	103059778	G	A	103059778	2	1	88	1	0	0	0	0	0	0	0	1	7648	1045	37	1		1	IL18RAP	2	103059778	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1474914	103059778	140139595	52	26250										
EPB41L5	57669	broad.mit.edu	37	chr2	120833065	120833065	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttcttaggtatttatttgttCttcagttaaaacaagatatt	5	4	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:120833065C>G	uc002tmg.2	+	6	547	c.421C>G	c.(421-423)CTT>GTT	p.L141V	EPB41L5_uc010flk.2_Missense_Mutation_p.L141V|EPB41L5_uc010fll.2_Missense_Mutation_p.L141V|EPB41L5_uc002tmh.3_Missense_Mutation_p.L141V|EPB41L5_uc010flm.2_5'Flank	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	141	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						TTTATTTGTTCTTCAGTTAAA	0.284													0	0	0	0.020292	0	14	24										G	120833065	C	G	120833065	3	3	88	1	0	0	0	0	1	0	0	0	5157	913	32	1	439	1	EPB41L5	2	120833065	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	17773287	120833065	122366308	53	26251										
WDR33	55339	broad.mit.edu	37	chr2	128520696	128520696	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gattctaacagtgccgtcatCagagcatgtagcaaatttat	8	8	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:128520696C>G	uc002tpg.1	-	7	847	c.664G>C	c.(664-666)GAT>CAT	p.D222H	WDR33_uc002tph.1_Missense_Mutation_p.D222H	NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	222	WD 3.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GTGCCGTCATCAGAGCATGTA	0.408													0	0	0	0.024334	0	25	105										G	128520696	C	G	128520696	3	3	88	1	0	0	0	0	1	0	0	0	17284	826	29	1	3464	1	WDR33	2	128520696	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	7687631	128520696	114678677	54	26252										
NEB	4703	broad.mit.edu	37	chr2	152394433	152394433	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtggtggaaatgctctggacGatcaggaatggacctccaga	14	8	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:152394433G>A	uc010fnx.2	-	112	16143	c.15952C>T	c.(15952-15954)CGT>TGT	p.R5318C	NEB_uc002txr.2_Missense_Mutation_p.R1741C	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5318	Nebulin 145.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGCTCTGGACGATCAGGAATG	0.403													0	0	0	0.008291	0	9	42										A	152394433	G	A	152394433	3	1	88	1	0	0	0	0	1	0	0	0	10302	1058	37	1	4803	1	NEB	2	152394433	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	23873737	152394433	90804940	55	26253										
ACVR1C	130399	broad.mit.edu	37	chr2	158397605	158397605	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tatttccaaaattttacctcCgactgaacacctccgggcta	5	13	0	1	rs149435555		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:158397605C>G	uc002tzk.3	-	7	1465	c.1222G>C	c.(1222-1224)GGA>CGA	p.G408R	ACVR1C_uc002tzl.3_Missense_Mutation_p.G328R|ACVR1C_uc010fof.2_Missense_Mutation_p.G251R|ACVR1C_uc010foe.2_Missense_Mutation_p.G358R	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	408	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						ATTTTACCTCCGACTGAACAC	0.373													0	0	0	0.021022	0	33	181										G	158397605	C	G	158397605	3	3	88	1	0	0	0	0	1	0	0	0	222	661	23	4	271	4	ACVR1C	2	158397605	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6003172	158397605	84801768	56	26254										
C2orf77	129881	broad.mit.edu	37	chr2	170502386	170502386	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tagccttctctttgacttttGaaaattatattttggtccct	5	8	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:170502386G>A	uc002ufe.2	-	9	1718	c.1624C>T	c.(1624-1626)CAA>TAA	p.Q542*		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	542											0						TTTGACTTTTGAAAATTATAT	0.348													0	0	0	0.006122	0	19	58										A	170502386	G	A	170502386	4	1	88	1	0	0	0	0	0	1	0	0	2194	1299	45	1	38	1	C2orf77	2	170502386	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	12104781	170502386	72696987	57	26255										
TTN	7273	broad.mit.edu	37	chr2	179471896	179471896	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcagtctctattggttgtctCcaagtatgcatcttggcatc	8	10	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:179471896C>T	uc010zfg.1	-	227	45953	c.45729G>A	c.(45727-45729)TGG>TGA	p.W15243*	uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.W8938*|TTN_uc010zfi.1_Nonsense_Mutation_p.W8871*|TTN_uc010zfj.1_Nonsense_Mutation_p.W8746*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16170							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGTTGTCTCCAAGTATGCA	0.393													0	0	0	0.012213	0	32	175										T	179471896	C	T	179471896	4	4	88	1	0	0	0	0	0	1	0	0	16732	856	30	1	54600	1	TTN	2	179471896	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	8969510	179471896	63727477	58	26256										
TTN	7273	broad.mit.edu	37	chr2	179639030	179639030	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atccttgaccgtgaggttctGacgtccacgacgagatgtaa	11	10	1	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:179639030G>C	uc010zfg.1	-	30	7185	c.6961C>G	c.(6961-6963)CAG>GAG	p.Q2321E	TTN_uc010zfh.1_Missense_Mutation_p.Q2275E|TTN_uc010zfi.1_Missense_Mutation_p.Q2275E|TTN_uc010zfj.1_Missense_Mutation_p.Q2275E|TTN_uc002unb.2_Missense_Mutation_p.Q2321E|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2321							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGAGGTTCTGACGTCCACGA	0.403													0	0	0	0.021523	0	24	121										C	179639030	G	C	179639030	3	2	88	1	0	0	0	0	1	0	0	0	16732	1299	45	1	104359	1	TTN	2	179639030	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	167134	179639030	63560343	59	26257										
ITGAV	3685	broad.mit.edu	37	chr2	187514604	187514604	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tttggtgtagatcgagctatCttatacaggtgagcattttc	10	6	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:187514604C>G	uc002upq.2	+	14	1665	c.1389C>G	c.(1387-1389)ATC>ATG	p.I463M	ITGAV_uc010frs.2_Missense_Mutation_p.I427M|ITGAV_uc010zfv.1_Missense_Mutation_p.I417M	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	463	FG-GAP 7.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ATCGAGCTATCTTATACAGGT	0.289													0	0	0	0.001984	0	6	49										G	187514604	C	G	187514604	3	3	88	1	0	0	0	0	1	0	0	0	7888	903	32	1	1494	1	ITGAV	2	187514604	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	7875574	187514604	55684769	60	26258										
ALS2CR8	79800	broad.mit.edu	37	chr2	203825996	203825996	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accgtggctactgtgtaagtGagactgaattagaaagtgtc	12	6	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:203825996G>C	uc002uzo.2	+	8	959	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	ALS2CR8_uc002uzn.2_Missense_Mutation_p.E125Q|ALS2CR8_uc002uzm.2_Missense_Mutation_p.E227Q|ALS2CR8_uc010zhy.1_Intron|ALS2CR8_uc010zhz.1_Intron|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.E151Q|ALS2CR8_uc010zib.1_Missense_Mutation_p.E151Q|ALS2CR8_uc010zic.1_Missense_Mutation_p.E139Q|ALS2CR8_uc002uzp.2_Missense_Mutation_p.E227Q	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	227										large_intestine(1)|ovary(1)	2						CTGTGTAAGTGAGACTGAATT	0.413													0	0	0	0.016522	0	22	41										C	203825996	G	C	203825996	3	2	88	1	0	0	0	0	1	0	0	0	555	1291	45	1	701	1	ALS2CR8	2	203825996	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	16311392	203825996	39373377	61	26259										
ALS2CR8	79800	broad.mit.edu	37	chr2	203826043	203826043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tttcacaagcagcaaacacaGagtgtttgggggacccgtca	11	10	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:203826043G>A	uc002uzo.2	+	8	1006	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	ALS2CR8_uc002uzn.2_Silent_p.Q140Q|ALS2CR8_uc002uzm.2_Silent_p.Q242Q|ALS2CR8_uc010zhy.1_Intron|ALS2CR8_uc010zhz.1_Intron|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Silent_p.Q166Q|ALS2CR8_uc010zib.1_Silent_p.Q166Q|ALS2CR8_uc010zic.1_Silent_p.Q154Q|ALS2CR8_uc002uzp.2_Silent_p.Q242Q	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	242										large_intestine(1)|ovary(1)	2						AGCAAACACAGAGTGTTTGGG	0.448													0	0	0	0.010504	0	20	41										A	203826043	G	A	203826043	2	1	88	1	0	0	0	0	0	0	0	1	555	933	33	1		1	ALS2CR8	2	203826043	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	47	203826043	39373330	62	26260										
NDUFS1	4719	broad.mit.edu	37	chr2	207009731	207009731	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acttccaaccgcatccattaCatcaatggattctgtctttc	4	13	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:207009731C>T	uc002vbe.2	-	9	884	c.757G>A	c.(757-759)GTA>ATA	p.V253I	NDUFS1_uc010ziq.1_Missense_Mutation_p.V267I|NDUFS1_uc010zir.1_Missense_Mutation_p.V217I|NDUFS1_uc010zis.1_Missense_Mutation_p.V196I|NDUFS1_uc010zit.1_Missense_Mutation_p.V142I|NDUFS1_uc010ziu.1_Missense_Mutation_p.V137I	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	253					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	GCATCCATTACATCAATGGAT	0.378													0	0	0	0.020292	0	14	73										T	207009731	C	T	207009731	3	4	88	1	0	0	0	0	1	0	0	0	10291	478	17	2	1470	2	NDUFS1	2	207009731	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3183688	207009731	36189642	63	26261										
AAMP	14	broad.mit.edu	37	chr2	219129789	219129789	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agccgtgtggccccggtagtCagtaagcaggcggccggtcc	16	13	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219129789C>G	uc002vhk.2	-	10	1267	c.1183G>C	c.(1183-1185)GAC>CAC	p.D395H	AAMP_uc002vhj.2_Missense_Mutation_p.D376H|AAMP_uc010fvo.2_Missense_Mutation_p.D395H|AAMP_uc002vhl.2_Missense_Mutation_p.D396H	NM_001087	NP_001078	Q13685	AAMP_HUMAN	angio-associated, migratory cell protein	395	WD 7.				angiogenesis|cell differentiation|positive regulation of endothelial cell migration|smooth muscle cell migration	cell surface|cytoplasm|plasma membrane	heparin binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCGGTAGTCAGTAAGCAGG	0.607													0	0	0	0.010818	0	33	156										G	219129789	C	G	219129789	3	3	88	1	0	0	0	0	1	0	0	0	17	826	29	1	129	1	AAMP	2	219129789	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	12120058	219129789	24069584	64	26262										
PNKD	25953	broad.mit.edu	37	chr2	219209680	219209680	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctggaagagctccgccggctGaaggatatgcacaagagcaa	13	10	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219209680G>A	uc002vhn.2	+	10	1278	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	PNKD_uc002vhq.2_Silent_p.L354L	NM_015488	NP_056303	Q8N490	PNKD_HUMAN	myofibrillogenesis regulator 1 isoform 1	378	Substrate (By similarity).					membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCGCCGGCTGAAGGATATGC	0.682													0	0	0	0.020292	0	14	42										A	219209680	G	A	219209680	2	1	88	1	0	0	0	0	0	0	0	1	12146	1277	45	1		1	PNKD	2	219209680	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	79891	219209680	23989693	65	26263										
STK36	27148	broad.mit.edu	37	chr2	219544683	219544683	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caaggtggctcctggcacagCccctctgcccagactcgggg	13	16	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219544683C>A	uc002viu.2	+	9	1282	c.1016C>A	c.(1015-1017)GCC>GAC	p.A339D	STK36_uc002viv.2_Missense_Mutation_p.A339D	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	339					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CCTGGCACAGCCCCTCTGCCC	0.577													1	0	3.99206e-14	0.007413	4.2957e-14	20	103										A	219544683	C	A	219544683	3	1	88	1	0	0	0	0	1	0	0	0	15301	739	26	4	1046	4	STK36	2	219544683	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	335003	219544683	23654690	66	26264										
CYP27A1	1593	broad.mit.edu	37	chr2	219679343	219679343	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcctgaaagcttccagcccCaccgctggctgagaaacagc	10	15	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:219679343C>T	uc002viz.3	+	8	1773	c.1339C>T	c.(1339-1341)CAC>TAC	p.H447Y		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	447					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	CTTCCAGCCCCACCGCTGGCT	0.607													0	0	0	0.010729	0	10	65										T	219679343	C	T	219679343	3	4	88	1	0	0	0	0	1	0	0	0	4158	594	21	2	1369	2	CYP27A1	2	219679343	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	134660	219679343	23520030	67	26265										
SCG2	7857	broad.mit.edu	37	chr2	224463499	224463499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggaattctcttcatacatagGagggaattgcatgtgcttaa	10	6	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:224463499G>A	uc002vnm.2	-	2	635	c.502C>T	c.(502-504)CCT>TCT	p.P168S		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	168					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCATACATAGGAGGGAATTGC	0.403													0	0	0	0.017118	0	36	165										A	224463499	G	A	224463499	3	1	88	1	0	0	0	0	1	0	0	0	13891	1174	41	1	1355	1	SCG2	2	224463499	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4784156	224463499	18735874	68	26266										
TRIP12	9320	broad.mit.edu	37	chr2	230656630	230656630	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagctctgcctagaggattgCtctcatcatctgtggattct	9	11	5	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:230656630C>A	uc002vpw.1	-	28	4251	c.4142G>T	c.(4141-4143)AGC>ATC	p.S1381I	TRIP12_uc002vpx.1_Missense_Mutation_p.S1429I|TRIP12_uc002vpy.1_Missense_Mutation_p.S1111I	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1381					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TAGAGGATTGCTCTCATCATC	0.383													1	0	6.21074e-16	0.011902	6.75875e-16	39	218										A	230656630	C	A	230656630	3	1	88	1	0	0	0	0	1	0	0	0	16553	797	28	4	1892	4	TRIP12	2	230656630	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6193131	230656630	12542743	69	26267										
NCL	4691	broad.mit.edu	37	chr2	232326368	232326368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggttcaatttcatcttcatCctcatcctcgtcctcgtcat	4	14	6	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:232326368C>T	uc002vru.2	-	3	637	c.496G>A	c.(496-498)GAT>AAT	p.D166N	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	nucleolin	166	Asp/Glu-rich (acidic).				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		tcatcttcatcctcatcctcg	0.239													0	0	0	0.007413	0	20	24										T	232326368	C	T	232326368	3	4	88	1	0	0	0	0	1	0	0	0	10226	855	30	1	1684	1	NCL	2	232326368	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1669738	232326368	10873005	70	26268										
IQCA1	79781	broad.mit.edu	37	chr2	237396819	237396819	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcctcatcgaaagggatacTctttacagggtatttctgca	9	9	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:237396819T>C	uc002vvz.1	-	4	654	c.472A>G	c.(472-474)AGT>GGT	p.S158G	IQCA1_uc002vwb.2_Missense_Mutation_p.S165G|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.S158G	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	158							ATP binding			ovary(1)	1						AAAGGGATACTCTTTACAGGG	0.398													0	0	0	0.014758	0	5	20										C	237396819	T	C	237396819	3	2	88	1	0	0	0	0	1	0	0	0	7802	1551	54	5	2060	5	IQCA1	2	237396819	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	5070451	237396819	5802554	71	26269										
RBM44	375316	broad.mit.edu	37	chr2	238726129	238726129	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gactcacagcaggaatatcaCagtgcagaagaacaagaata	9	8	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:238726129C>T	uc002vxi.3	+	3	702	c.570C>T	c.(568-570)CAC>CAT	p.H190H		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	189							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGGAATATCACAGTGCAGAAG	0.333													0	0	0	0.004482	0	8	26										T	238726129	C	T	238726129	2	4	88	1	0	0	0	0	0	0	0	1	13138	477	17	2		2	RBM44	2	238726129	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1329310	238726129	4473244	72	26270										
PER2	8864	broad.mit.edu	37	chr2	239167208	239167208	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gttcttgcaggccaactcctCggggaagctgacccccaggc	12	15	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr2:239167208C>T	uc002vyc.2	-	15	1942	c.1705G>A	c.(1705-1707)GAG>AAG	p.E569K	PER2_uc010znv.1_Missense_Mutation_p.E569K	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	569	CSNK1E binding domain (By similarity).				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GCCAACTCCTCGGGGAAGCTG	0.552													0	0	0	0.008291	0	11	47										T	239167208	C	T	239167208	3	4	88	1	0	0	0	0	1	0	0	0	11730	893	31	1	2098	1	PER2	2	239167208	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	441079	239167208	4032165	73	26271										
KCNH8	131096	broad.mit.edu	37	chr3	19479720	19479720	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggcaacaataccttggggggCccgtcgatccgaagtgccta	13	12	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:19479720C>T	uc003cbk.1	+	8	1437	c.1242C>T	c.(1240-1242)GGC>GGT	p.G414G	KCNH8_uc011awe.1_Silent_p.G414G|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_Silent_p.G45G	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	414	Extracellular (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						CCTTGGGGGGCCCGTCGATCC	0.488													0	0	0	0.01441	0	55	486										T	19479720	C	T	19479720	2	4	88	1	0	0	0	0	0	0	0	1	8038	726	26	2		2	KCNH8	3	19479720	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		19479720	178542710	74	26272										
GPD1L	23171	broad.mit.edu	37	chr3	32188164	32188164	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcaaagaacttctgcagactCcaaattttcgaattaccgtg	6	10	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:32188164C>G	uc003cew.2	+	5	616	c.556C>G	c.(556-558)CCA>GCA	p.P186A		NM_015141	NP_055956	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	186					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity				0						TCTGCAGACTCCAAATTTTCG	0.433													0	0	0	0.01441	0	99	306										G	32188164	C	G	32188164	3	3	88	1	0	0	0	0	1	0	0	0	6605	855	30	1	574	1	GPD1L	3	32188164	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	12708444	32188164	165834266	75	26273										
SCN5A	6331	broad.mit.edu	37	chr3	38601887	38601887	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aggaggacgttcatgatggaCgggatggcgcccaccagggc	17	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:38601887C>T	uc003cio.2	-	23	4190	c.3996G>A	c.(3994-3996)CCG>CCA	p.P1332P	SCN5A_uc003cin.2_Silent_p.P1331P|SCN5A_uc003cil.3_Silent_p.P1332P|SCN5A_uc010hhi.2_Silent_p.P1332P|SCN5A_uc010hhk.2_Silent_p.P1331P|SCN5A_uc011ayr.1_Silent_p.P1278P|SCN5A_uc010hhj.1_Silent_p.P942P	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1332			P -> L (in LQT3).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCATGATGGACGGGATGGCGC	0.582													0	0	0	0.012319	0	17	44										T	38601887	C	T	38601887	2	4	88	1	0	0	0	0	0	0	0	1	13922	523	19	2		2	SCN5A	3	38601887	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6413723	38601887	159420543	76	26274										
SCN5A	6331	broad.mit.edu	37	chr3	38616877	38616877	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtagcaggtcttgcgcaaccGccaccagaccttccctgggg	12	15	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:38616877G>A	uc003cio.2	-	20	3771	c.3577C>T	c.(3577-3579)CGG>TGG	p.R1193W	SCN5A_uc003cin.2_Missense_Mutation_p.R1192W|SCN5A_uc003cil.3_Missense_Mutation_p.R1193W|SCN5A_uc010hhi.2_Missense_Mutation_p.R1193W|SCN5A_uc010hhk.2_Missense_Mutation_p.R1192W|SCN5A_uc011ayr.1_Missense_Mutation_p.R1139W|SCN5A_uc010hhj.1_Missense_Mutation_p.R803W	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1193					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.R1193W(1)		ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TTGCGCAACCGCCACCAGACC	0.612													0	0	0	0.001984	0	7	7										A	38616877	G	A	38616877	3	1	88	1	0	0	0	0	1	0	0	0	13922	1086	38	2	2509	2	SCN5A	3	38616877	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	14990	38616877	159405553	77	26275										
ZBTB47	92999	broad.mit.edu	37	chr3	42702987	42702987	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tattctgcagtgtgtgacatGtggcaaagctttcaagaagc	11	7	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:42702987G>A	uc003clu.1	+	2	458	c.356G>A	c.(355-357)TGT>TAT	p.C119Y		NM_145166	NP_660149	Q9UFB7	ZBT47_HUMAN	zinc finger protein 651	119	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.216)		TGTGTGACATGTGGCAAAGCT	0.413													0	0	0	0.021022	0	31	49										A	42702987	G	A	42702987	3	1	88	1	0	0	0	0	1	0	0	0	17545	1377	48	2	1490	2	ZBTB47	3	42702987	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4086110	42702987	155319443	78	26276										
DHX30	22907	broad.mit.edu	37	chr3	47887699	47887699	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gccccagaactccggctgcaGagtgatgacatcttgccctt	10	14	1	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:47887699G>C	uc003cru.2	+	11	1563	c.1137G>C	c.(1135-1137)CAG>CAC	p.Q379H	DHX30_uc003crt.2_Missense_Mutation_p.Q340H	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	379						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TCCGGCTGCAGAGTGATGACA	0.542													0	0	0	0.01441	0	63	122										C	47887699	G	C	47887699	3	2	88	1	0	0	0	0	1	0	0	0	4504	933	33	1	1182	1	DHX30	3	47887699	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5184712	47887699	150134731	79	26277										
MAP4	4134	broad.mit.edu	37	chr3	47956392	47956392	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aacacagaatcctcctcggcCggcaagctgcactttttccc	7	16	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:47956392C>G	uc003csb.2	-	8	2440	c.1914G>C	c.(1912-1914)CCG>CCC	p.P638P	MAP4_uc003csc.3_Silent_p.P638P|MAP4_uc011bbf.1_Silent_p.P615P|MAP4_uc003csf.3_Silent_p.P655P	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	638					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		CCTCCTCGGCCGGCAAGCTGC	0.443													0	0	0	0.01441	0	71	135										G	47956392	C	G	47956392	2	3	88	1	0	0	0	0	0	0	0	1	9258	639	23	4		4	MAP4	3	47956392	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	68693	47956392	150066038	80	26278										
RNF123	63891	broad.mit.edu	37	chr3	49742439	49742439	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccccatgcaggccctggctgTtggggggccactgcccctgc	14	17	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:49742439T>C	uc003cxh.2	+	23	2068	c.1982T>C	c.(1981-1983)GTT>GCT	p.V661A	RNF123_uc010hky.1_Missense_Mutation_p.V323A|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	661						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GCCCTGGCTGTTGGGGGGCCA	0.677													0	0	0	0.004482	0	7	5										C	49742439	T	C	49742439	3	2	88	1	0	0	0	0	1	0	0	0	13433	1725	60	5	2068	5	RNF123	3	49742439	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	1786047	49742439	148279991	81	26279										
BAP1	8314	broad.mit.edu	37	chr3	52436887	52436887	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cttcagcagtgccagcagctCctgccaaaacccagcattgc	8	16	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:52436887C>G	uc003ddx.2	-	15	2006	c.1891G>C	c.(1891-1893)GAG>CAG	p.E631Q	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_Intron	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	631	Potential.|Interaction with BRCA1.				monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.E631_A634del(1)|p.E631fs*3(1)		pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		GCCAGCAGCTCCTGCCAAAAC	0.567			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.006122	0	18	84										G	52436887	C	G	52436887	3	3	88	1	0	0	0	0	1	0	0	0	1311	869	30	1	310	1	BAP1	3	52436887	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2694448	52436887	145585543	82	26280										
SFMBT1	51460	broad.mit.edu	37	chr3	52939153	52939153	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctcactttggttgtccttctCagttggcaaactgctcataa	7	11	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:52939153C>G	uc003dgf.2	-	22	3169	c.2600G>C	c.(2599-2601)TGA>TCA	p.*867S	SFMBT1_uc010hmr.2_Nonstop_Mutation_p.*771S|SFMBT1_uc003dgg.2_Nonstop_Mutation_p.*867S|SFMBT1_uc003dgh.2_Nonstop_Mutation_p.*867S	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	867					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		TTGTCCTTCTCAGTTGGCAAA	0.453													0	0	0	0.01441	0	59	39										G	52939153	C	G	52939153	4	3	88	1	0	0	0	0	0	0	0	0	14157	837	29	1	4	1	SFMBT1	3	52939153	Nonstop_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	502266	52939153	145083277	83	26281										
EPHA6	285220	broad.mit.edu	37	chr3	96706766	96706766	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	actgtattgtggagctgatgGagattggctggttcctcttg	14	6	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:96706766G>A	uc010how.1	+	3	1086	c.1043G>A	c.(1042-1044)GGA>GAA	p.G348E	EPHA6_uc003drp.1_Missense_Mutation_p.G348E	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	253	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GGAGCTGATGGAGATTGGCTG	0.428													0	0	0	0.01441	0	75	69										A	96706766	G	A	96706766	3	1	88	1	0	0	0	0	1	0	0	0	5171	1174	41	1	1053	1	EPHA6	3	96706766	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	43767613	96706766	101315664	84	26282										
MORC1	27136	broad.mit.edu	37	chr3	108782032	108782032	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttcttctgcctttttaacttCatctttaaatgctcctttaa	2	10	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:108782032C>T	uc003dxl.2	-	10	949	c.862G>A	c.(862-864)GAA>AAA	p.E288K	MORC1_uc011bhn.1_Missense_Mutation_p.E288K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	288	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TTTTTAACTTCATCTTTAAAT	0.254													0	0	0	0.007413	0	16	109										T	108782032	C	T	108782032	3	4	88	1	0	0	0	0	1	0	0	0	9701	835	29	1	2168	1	MORC1	3	108782032	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	12075266	108782032	89240398	85	26283										
GSK3B	2932	broad.mit.edu	37	chr3	119562103	119562103	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agacttagaacgttcttaccTgacgctgctgtggcatttgt	10	9	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:119562103T>A	uc003edo.2	-	10	2177	c.1194A>T	c.(1192-1194)TCA>TCT	p.S398S	GSK3B_uc003edn.2_Silent_p.S411S|GSK3B_uc003edm.2_Intron	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2	398					axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	CGTTCTTACCTGACGCTGCTG	0.318													0	0	0	0.008361	0	29	63										A	119562103	T	A	119562103	2	1	88	1	0	0	0	0	0	0	0	1	6824	1594	55	5		5	GSK3B	3	119562103	Silent	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	10780071	119562103	78460327	86	26284										
EEFSEC	60678	broad.mit.edu	37	chr3	127981020	127981020	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cggccaagccggggggaccaGaggcccccgaaactgaagct	15	14	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:127981020G>A	uc003eki.2	+	3	612	c.574G>A	c.(574-576)GAG>AAG	p.E192K	EEFSEC_uc003ekj.2_Missense_Mutation_p.E192K	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	192						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGGGGGACCAGAGGCCCCCGA	0.557													0	0	0	0.012319	0	20	162										A	127981020	G	A	127981020	3	1	88	1	0	0	0	0	1	0	0	0	4931	943	33	1	584	1	EEFSEC	3	127981020	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	8418917	127981020	70041410	87	26285										
H1FX	8971	broad.mit.edu	37	chr3	129034635	129034635	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggttcttcttcttgctattCttcctcttcttagatgggga	8	9	6	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:129034635C>G	uc003elx.2	-	1	486	c.111G>C	c.(109-111)AAG>AAC	p.K37N	C3orf47_uc011bkv.1_5'Flank	NM_006026	NP_006017	Q92522	H1X_HUMAN	H1 histone family, member X	37					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCTTGCTATTCTTCCTCTTCT	0.622													0	0	0	0.004672	0	3	9										G	129034635	C	G	129034635	3	3	88	1	0	0	0	0	1	0	0	0	6923	912	32	1	534	1	H1FX	3	129034635	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1053615	129034635	68987795	88	26286										
ARMC8	25852	broad.mit.edu	37	chr3	137964026	137964026	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atgaagacatccggaagaagGtgagtctgggagaggggcgt	18	5	1	5			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:137964026G>A	uc003esa.1	+	13	1459	c.1092_splice	c.e13+1	p.K364_splice	ARMC8_uc003erw.2_Missense_Mutation_p.V365M|ARMC8_uc003erx.2_Missense_Mutation_p.V365M|ARMC8_uc003ery.2_Missense_Mutation_p.V337M|ARMC8_uc003erz.2_Missense_Mutation_p.V337M|ARMC8_uc011bmf.1_Splice_Site_p.K347_splice|ARMC8_uc011bmg.1_Splice_Site_p.K311_splice|ARMC8_uc011bmh.1_Splice_Site_p.K305_splice|ARMC8_uc003esb.1_Splice_Site_p.K336_splice|ARMC8_uc003esc.1_Splice_Site_p.K136_splice	NM_015396	NP_056211	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8 isoform 2								binding				0						CCGGAAGAAGGTGAGTCTGGG	0.517													0	0	0	0.021523	0	23	74										A	137964026	G	A	137964026	5	1	88	1	0	0	0	0	0	0	1	0	957	1275	44	2	1139	2	ARMC8	3	137964026	Splice_Site	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	8929391	137964026	60058404	89	26287										
MED12L	116931	broad.mit.edu	37	chr3	151112625	151112625	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagcagcaacagcgacttctCaggcaagcccagactcggcc	10	16	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:151112625C>T	uc003eyp.2	+	37	5723	c.5685C>T	c.(5683-5685)CTC>CTT	p.L1895L	MED12L_uc011bnz.1_Silent_p.L1755L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1895	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCGACTTCTCAGGCAAGCCC	0.522													0	0	0	0.01441	0	50	62										T	151112625	C	T	151112625	2	4	88	1	0	0	0	0	0	0	0	1	9429	813	29	1		1	MED12L	3	151112625	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	13148599	151112625	46909805	90	26288										
SMC4	10051	broad.mit.edu	37	chr3	160141236	160141236	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gctgtatgggcgaaaaagatGaccgaaattcaaactcctga	10	8	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:160141236G>A	uc003fdh.2	+	14	2156	c.2043G>A	c.(2041-2043)ATG>ATA	p.M681I	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.M445I|SMC4_uc003fdi.2_Missense_Mutation_p.M656I|SMC4_uc003fdj.2_Missense_Mutation_p.M681I|SMC4_uc010hwd.2_Missense_Mutation_p.M681I|SMC4_uc003fdl.2_Missense_Mutation_p.M384I	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	681	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CGAAAAAGATGACCGAAATTC	0.269													0	0	0	0.01441	0	73	116										A	160141236	G	A	160141236	3	1	88	1	0	0	0	0	1	0	0	0	14785	1290	45	1	2093	1	SMC4	3	160141236	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	9028611	160141236	37881194	91	26289										
MUC4	4585	broad.mit.edu	37	chr3	195518308	195518308	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctagtgtcgctgttgttgagCctgttgaggtgactggggca	16	7	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:195518308C>G	uc011bto.1	-	2	603	c.143G>C	c.(142-144)GGC>GCC	p.G48A	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_5'Flank	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	48					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTTGTTGAGCCTGTTGAGGT	0.403													0	0	0	0.01441	0	49	258										G	195518308	C	G	195518308	3	3	88	1	0	0	0	0	1	0	0	0	9978	739	26	4		4	MUC4	3	195518308	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	35377072	195518308	2504122	92	26290										
SENP5	205564	broad.mit.edu	37	chr3	196613274	196613274	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atcagacaagttctgtcagtGatgacagagtaaaactgtca	9	7	4	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr3:196613274G>A	uc003fwz.3	+	2	1471	c.1222G>A	c.(1222-1224)GAT>AAT	p.D408N	SENP5_uc011bty.1_Missense_Mutation_p.D408N	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	408					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		TTCTGTCAGTGATGACAGAGT	0.423													0	0	0	0.00632	0	27	107										A	196613274	G	A	196613274	3	1	88	1	0	0	0	0	1	0	0	0	14049	1290	45	1	1224	1	SENP5	3	196613274	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1094966	196613274	1409156	93	26291										
WHSC1	7468	broad.mit.edu	37	chr4	1902964	1902964	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttgtgtctaagatctcaagtCcttcagataaaaaggtattt	7	6	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:1902964C>G	uc003gdz.3	+	2	759	c.583C>G	c.(583-585)CCT>GCT	p.P195A	WHSC1_uc003geb.3_Missense_Mutation_p.P195A|WHSC1_uc003gec.3_Missense_Mutation_p.P195A|WHSC1_uc003ged.3_Missense_Mutation_p.P195A|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.P195A|WHSC1_uc003gdy.1_Missense_Mutation_p.P195A|WHSC1_uc010icd.1_Missense_Mutation_p.P195A|WHSC1_uc003gea.1_Missense_Mutation_p.P195A|WHSC1_uc010ice.1_Missense_Mutation_p.P195A|WHSC1_uc003geg.1_Missense_Mutation_p.P195A|WHSC1_uc003geh.1_Missense_Mutation_p.P195A	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	195					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GATCTCAAGTCCTTCAGATAA	0.493			T	IGH@	MM								0	0	0	0.006214	0	8	62										G	1902964	C	G	1902964	3	3	88	1	0	0	0	0	1	0	0	0	17359	855	30	1	585	1	WHSC1	4	1902964	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		1902964	189251312	94	26292										
MXD4	10608	broad.mit.edu	37	chr4	2254191	2254191	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cgtggtgtggcgggtgctgtCggggcccaggggcaccagtt	20	10	0	0	rs141784187	by1000genomes	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:2254191C>T	uc003geu.1	-	4	285	c.253G>A	c.(253-255)GAC>AAC	p.D85N		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	85	Helix-loop-helix motif.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						CGGGTGCTGTCGGGGCCCAGG	0.632													0	0	0	0.006214	0	9	40										T	2254191	C	T	2254191	3	4	88	1	0	0	0	0	1	0	0	0	10001	884	31	1	388	1	MXD4	4	2254191	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	351227	2254191	188900085	95	26293										
HTT	3064	broad.mit.edu	37	chr4	3237489	3237489	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcggctctgggcctgatgctCacctgcatgtacacaggtga	13	12	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:3237489C>T	uc011bvq.1	+	64	8920	c.8775C>T	c.(8773-8775)CTC>CTT	p.L2925L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2923					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GCCTGATGCTCACCTGCATGT	0.607													0	0	0	0.001984	0	7	22										T	3237489	C	T	3237489	2	4	88	1	0	0	0	0	0	0	0	1	7457	813	29	1		1	HTT	4	3237489	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	983298	3237489	187916787	96	26294										
D4S234E	27065	broad.mit.edu	37	chr4	4419001	4419001	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaggcttggagagctactacGcggagcaagactccagtgcc	13	11	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:4419001G>A	uc011bvz.1	+	8	1678	c.397G>A	c.(397-399)GCG>ACG	p.A133T	D4S234E_uc011bwa.1_Missense_Mutation_p.A94T|D4S234E_uc003ghz.2_Missense_Mutation_p.A133T|D4S234E_uc003gia.2_Missense_Mutation_p.A133T|D4S234E_uc003gib.2_Missense_Mutation_p.A133T	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	133	Lumenal (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		GAGCTACTACGCGGAGCAAGA	0.567													0	0	0	0.007413	0	20	108										A	4419001	G	A	4419001	3	1	88	1	0	0	0	0	1	0	0	0	4214	1087	38	2	411	2	D4S234E	4	4419001	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1181512	4419001	186735275	97	26295										
TBC1D1	23216	broad.mit.edu	37	chr4	37903928	37903928	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccggctttgcgtttcaccctCtggactgagatgtgaacctg	11	12	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:37903928C>T	uc003gtb.2	+	2	555	c.212C>T	c.(211-213)TCT>TTT	p.S71F	TBC1D1_uc011byd.1_Missense_Mutation_p.S71F|TBC1D1_uc010ifd.2_Missense_Mutation_p.S71F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	71						nucleus	Rab GTPase activator activity			ovary(1)	1						GTTTCACCCTCTGGACTGAGA	0.547													0	0	0	0.01892	0	24	128										T	37903928	C	T	37903928	3	4	88	1	0	0	0	0	1	0	0	0	15594	913	32	1	214	1	TBC1D1	4	37903928	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	33484927	37903928	153250348	98	26296										
N4BP2	55728	broad.mit.edu	37	chr4	40123292	40123292	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catgggattggtattagtaaCgctgactcacagtctacttg	10	8	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:40123292C>T	uc003guy.3	+	9	3899	c.3561C>T	c.(3559-3561)AAC>AAT	p.N1187N	N4BP2_uc010ifq.2_Silent_p.N1107N|N4BP2_uc010ifr.2_Silent_p.N1107N	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1187						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GTATTAGTAACGCTGACTCAC	0.413													0	0	0	0.01441	0	61	101										T	40123292	C	T	40123292	2	4	88	1	0	0	0	0	0	0	0	1	10110	535	19	2		2	N4BP2	4	40123292	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2219364	40123292	151030984	99	26297										
TMPRSS11B	132724	broad.mit.edu	37	chr4	69101948	69101948	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tatcattgtatgtgactccaGaaatatgaaaatcaccttga	6	7	2	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:69101948G>A	uc003hdw.3	-	3	297	c.161C>T	c.(160-162)TCT>TTT	p.S54F		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	54	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGTGACTCCAGAAATATGAAA	0.303													0	0	0	0.001984	0	6	27										A	69101948	G	A	69101948	3	1	88	1	0	0	0	0	1	0	0	0	16237	942	33	1	1121	1	TMPRSS11B	4	69101948	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	28978656	69101948	122052328	100	26298										
DCK	1633	broad.mit.edu	37	chr4	71888182	71888182	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttccaaacatatgcctgtctCagtcgaataagagctcagct	7	11	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:71888182C>T	uc003hfx.2	+	3	594	c.306C>T	c.(304-306)CTC>CTT	p.L102L	DCK_uc011cbb.1_Silent_p.L30L	NM_000788	NP_000779	P27707	DCK_HUMAN	deoxycytidine kinase	102					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	ATGCCTGTCTCAGTCGAATAA	0.403													0	0	0	0.016522	0	24	102										T	71888182	C	T	71888182	2	4	88	1	0	0	0	0	0	0	0	1	4290	813	29	1		1	DCK	4	71888182	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2786234	71888182	119266094	101	26299										
WDFY3	23001	broad.mit.edu	37	chr4	85742700	85742700	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcctggacgtttctcacactGtgacctagaacagaaaagaa	9	10	1	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:85742700G>A	uc003hpd.2	-	11	1536	c.1128C>T	c.(1126-1128)CAC>CAT	p.H376H	WDFY3_uc003hpf.2_Silent_p.H376H	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	376						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding	p.H376Y(1)		ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCTCACACTGTGACCTAGAA	0.338													0	0	0	0.01892	0	24	101										A	85742700	G	A	85742700	2	1	88	1	0	0	0	0	0	0	0	1	17267	1368	48	2		2	WDFY3	4	85742700	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	13854518	85742700	105411576	102	26300										
IBSP	3381	broad.mit.edu	37	chr4	88732815	88732815	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctctccaaatggtgggtttgAacctacaaccccaccacaag	7	14	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:88732815A>C	uc003hqx.3	+	7	805	c.707A>C	c.(706-708)GAA>GCA	p.E236A		NM_004967	NP_004958	P21815	SIAL_HUMAN	integrin-binding sialoprotein precursor	236					biomineral tissue development|cell adhesion|ossification						0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		GGTGGGTTTGAACCTACAACC	0.527													0	0	0	0.006214	0	9	41										C	88732815	A	C	88732815	3	2	88	1	0	0	0	0	1	0	0	0	7475	246	9	5	729	5	IBSP	4	88732815	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	2990115	88732815	102421461	103	26301										
ADH6	130	broad.mit.edu	37	chr4	100130048	100130048	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caacagacaagccgactcctCccaggccaaacacagcacag	7	17	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:100130048C>G	uc003hup.3	-	6	699	c.605G>C	c.(604-606)GGA>GCA	p.G202A	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.G202A|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Missense_Mutation_p.G202A	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	202	NAD (By similarity).				ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GCCGACTCCTCCCAGGCCAAA	0.458													0	0	0	0.01441	0	53	253										G	100130048	C	G	100130048	3	3	88	1	0	0	0	0	1	0	0	0	312	855	30	1	542	1	ADH6	4	100130048	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	11397233	100130048	91024228	104	26302										
TET2	54790	broad.mit.edu	37	chr4	106155204	106155204	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cctctggctacaaagctccaGaatggaagcccactgcctga	9	14	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:106155204G>A	uc003hxk.2	+	3	491	c.105G>A	c.(103-105)CAG>CAA	p.Q35Q	TET2_uc011cez.1_Silent_p.Q56Q|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.Q35Q|TET2_uc003hxi.1_Silent_p.Q35Q	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	35					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CAAAGCTCCAGAATGGAAGCC	0.463			Mis N|F		MDS								0	0	0	0.020292	0	15	43										A	106155204	G	A	106155204	2	1	88	1	0	0	0	0	0	0	0	1	15767	933	33	1		1	TET2	4	106155204	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6025156	106155204	84999072	105	26303										
TIGD4	201798	broad.mit.edu	37	chr4	153690793	153690793	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atccatcatcatcctcttcaTcagaagtgtaaaatccagtt	4	11	5	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:153690793T>C	uc003imy.2	-	2	2146	c.1364A>G	c.(1363-1365)GAT>GGT	p.D455G		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	455					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					ATCCTCTTCATCAGAAGTGTA	0.398													0	0	0	0.007413	0	19	52										C	153690793	T	C	153690793	3	2	88	1	0	0	0	0	1	0	0	0	15895	1435	50	5	178	5	TIGD4	4	153690793	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	47535589	153690793	37463483	106	26304										
WDR17	116966	broad.mit.edu	37	chr4	177058703	177058703	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtattgctgggggaacttccCgaaatggtgcttttatttgg	13	6	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:177058703C>T	uc003iuj.2	+	10	1528	c.1372C>T	c.(1372-1374)CGA>TGA	p.R458*	WDR17_uc003iuk.2_Nonsense_Mutation_p.R434*|WDR17_uc003ium.3_Nonsense_Mutation_p.R434*|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	458	WD 7.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GGGAACTTCCCGAAATGGTGC	0.274													0	0	0	0.006122	0	13	42										T	177058703	C	T	177058703	4	4	88	1	0	0	0	0	0	1	0	0	17274	644	23	2	1406	2	WDR17	4	177058703	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	23367910	177058703	14095573	107	26305										
NEIL3	55247	broad.mit.edu	37	chr4	178256885	178256885	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcatcatgattaatccacttGagtataaatataaaaatgga	5	5	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:178256885G>C	uc003iut.2	+	3	439	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	NEIL3_uc010irs.2_Missense_Mutation_p.E11Q	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	108					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		TAATCCACTTGAGTATAAATA	0.328								BER_DNA_glycosylases					0	0	0	0.00632	0	28	51										C	178256885	G	C	178256885	3	2	88	1	0	0	0	0	1	0	0	0	10320	1291	45	1	332	1	NEIL3	4	178256885	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1198182	178256885	12897391	108	26306										
ODZ3	55714	broad.mit.edu	37	chr4	183603124	183603124	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tatcttcaagaaagtggctcCtgcacgtgtgaccctaactg	9	11	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr4:183603124C>T	uc003ivd.1	+	10	2029	c.1992C>T	c.(1990-1992)TCC>TCT	p.S664S	ODZ3_uc003ive.1_Silent_p.S70S	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	664	EGF-like 5.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AAAGTGGCTCCTGCACGTGTG	0.488													0	0	0	0.007413	0	18	49										T	183603124	C	T	183603124	2	4	88	1	0	0	0	0	0	0	0	1	10836	668	24	2		2	ODZ3	4	183603124	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5346239	183603124	7551152	109	26307										
DNAH5	1767	broad.mit.edu	37	chr5	13885116	13885116	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accccggaagttaattgtgtGagaggaatgaatacgtttgc	12	6	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:13885116G>A	uc003jfd.2	-	19	3007	c.2965C>T	c.(2965-2967)CAC>TAC	p.H989Y		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	989	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTAATTGTGTGAGAGGAATGA	0.368									Kartagener_syndrome				0	0	0	0.008361	0	31	132										A	13885116	G	A	13885116	3	1	88	1	0	0	0	0	1	0	0	0	4604	1290	45	1	11153	1	DNAH5	5	13885116	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		13885116	167030144	110	26308										
NPR3	4883	broad.mit.edu	37	chr5	32712404	32712404	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gactctgagtactcgcacctCacgcgcgtggcgcccgccta	11	17	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:32712404C>G	uc003jhv.2	+	1	740	c.522C>G	c.(520-522)CTC>CTG	p.L174L	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Silent_p.L174L	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	174	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	ACTCGCACCTCACGCGCGTGG	0.682													0	0	0	0.008291	0	10	112										G	32712404	C	G	32712404	2	3	88	1	0	0	0	0	0	0	0	1	10596	813	29	1		1	NPR3	5	32712404	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	18827288	32712404	148202856	111	26309										
IL7R	3575	broad.mit.edu	37	chr5	35867471	35867471	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caagagatatatttcatcgaGacaaagaaattcttactgat	6	6	2	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:35867471G>C	uc003jjs.2	+	3	374	c.285G>C	c.(283-285)GAG>GAC	p.E95D	IL7R_uc011coo.1_Missense_Mutation_p.E95D|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	95	Extracellular (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ATTTCATCGAGACAAAGAAAT	0.383													0	0	0	0.024334	0	26	216										C	35867471	G	C	35867471	3	2	88	1	0	0	0	0	1	0	0	0	7705	933	33	1	295	1	IL7R	5	35867471	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3155067	35867471	145047789	112	26310										
OXCT1	5019	broad.mit.edu	37	chr5	41840601	41840601	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cacattggcaagttgaaattCcttgcacttttcctacaggg	8	10	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:41840601C>T	uc003jmn.2	-	7	1015	c.684G>A	c.(682-684)AGG>AGA	p.R228R		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	228					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	AGTTGAAATTCCTTGCACTTT	0.373													0	0	0	0.025465	0	34	177										T	41840601	C	T	41840601	2	4	88	1	0	0	0	0	0	0	0	1	11329	854	30	1		1	OXCT1	5	41840601	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5973130	41840601	139074659	113	26311										
CENPK	64105	broad.mit.edu	37	chr5	64814433	64814433	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tttgacatatggatcatgtgGaacatcaaataatctattta	6	5	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:64814433G>A	uc003jts.2	-	11	891	c.679C>T	c.(679-681)CCA>TCA	p.P227S	CENPK_uc003jtt.2_Missense_Mutation_p.P197S|CENPK_uc003jtu.2_Missense_Mutation_p.P227S	NM_022145	NP_071428	Q9BS16	CENPK_HUMAN	SoxLZ/Sox6 leucine zipper binding protein	227					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		GGATCATGTGGAACATCAAAT	0.333													0	0	0	0.016723	0	13	57										A	64814433	G	A	64814433	3	1	88	1	0	0	0	0	1	0	0	0	3235	1174	41	1	134	1	CENPK	5	64814433	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	22973832	64814433	116100827	114	26312										
ERBB2IP	55914	broad.mit.edu	37	chr5	65349677	65349677	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accacatgacagtgattgttCtgttgacttaggtatttcca	8	8	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:65349677C>T	uc003juk.1	+	21	2839	c.2531C>T	c.(2530-2532)TCT>TTT	p.S844F	ERBB2IP_uc003jui.1_Missense_Mutation_p.S844F|ERBB2IP_uc003juj.1_Missense_Mutation_p.S844F|ERBB2IP_uc011cqx.1_Missense_Mutation_p.S844F|ERBB2IP_uc011cqy.1_Missense_Mutation_p.S844F|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.S840F|ERBB2IP_uc003jul.1_Missense_Mutation_p.S840F	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	844					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGTGATTGTTCTGTTGACTTA	0.393													0	0	0	0.020292	0	15	36										T	65349677	C	T	65349677	3	4	88	1	0	0	0	0	1	0	0	0	5207	913	32	1	2605	1	ERBB2IP	5	65349677	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	535244	65349677	115565583	115	26313										
ERBB2IP	55914	broad.mit.edu	37	chr5	65349986	65349987	+	Frame_Shift_Ins	INS	-	-	T													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaggcaattttcaagtttgaINSttcaaatcataatcccgaag							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:65349986_65349987insT	uc003juk.1	+	21	3148_3149	c.2840_2841insT	c.(2839-2841)GATfs	p.D947fs	ERBB2IP_uc003jui.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc003juj.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc011cqx.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc011cqy.1_Frame_Shift_Ins_p.D947fs|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Frame_Shift_Ins_p.D943fs|ERBB2IP_uc003jul.1_Frame_Shift_Ins_p.D943fs	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	947					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TTCAAGTTTGATTCAAATCATA	0.386																		13	69	---	---								T	65349987	-	T	65349986	7	5	88	1	0	1	1	0	0	0	0	0	5207	333	12	0	2914	0	ERBB2IP	5	65349986	Frame_Shift_Ins	INS	-	TCGA-FJ-A3Z7-01A-12D-A23M-08	309	65349986	115565274	116	26314	130	2								
ERBB2IP	55914	broad.mit.edu	37	chr5	65349994	65349994	+	Missense_Mutation	SNP	C	C	G													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttttcaagtttgattcaaatCataatcccgaagagccaaat							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:65349994C>G	uc003juk.1	+	21	3156	c.2848C>G	c.(2848-2850)CAT>GAT	p.H950D	ERBB2IP_uc003jui.1_Missense_Mutation_p.H950D|ERBB2IP_uc003juj.1_Missense_Mutation_p.H950D|ERBB2IP_uc011cqx.1_Missense_Mutation_p.H950D|ERBB2IP_uc011cqy.1_Missense_Mutation_p.H950D|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.H946D|ERBB2IP_uc003jul.1_Missense_Mutation_p.H946D	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	950					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TGATTCAAATCATAATCCCGA	0.383													0	0	0	0.020292	0	13	63										G	65349994	C	G	65349994	3	3	88	1	0	0	0	0	1	0	0	0	5207	826	29	1	2922	1	ERBB2IP	5	65349994	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	8	65349994	115565266	117	26315	130	2								
HSD17B4	3295	broad.mit.edu	37	chr5	118788291	118788291	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atgggctcaccgctgaggttCgacgggcgggtggtactggt	18	9	1	1	rs143278360		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:118788291C>G	uc003ksj.2	+	1	144	c.21C>G	c.(19-21)TTC>TTG	p.F7L	HSD17B4_uc011cwg.1_5'UTR|HSD17B4_uc011cwh.1_Missense_Mutation_p.F7L|HSD17B4_uc011cwi.1_5'UTR|HSD17B4_uc003ksk.3_5'UTR	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	7	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	CGCTGAGGTTCGACGGGCGGG	0.667													0	0	0	0.006122	0	15	42										G	118788291	C	G	118788291	3	3	88	1	0	0	0	0	1	0	0	0	7386	883	31	1	23	1	HSD17B4	5	118788291	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	53438297	118788291	62126969	118	26316										
PCDHA7	56141	broad.mit.edu	37	chr5	140215764	140215764	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaaggtacgtgcagttgacgCtgactcaggctacaacgcgt	13	10	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:140215764C>T	uc003lhq.2	+	1	1796	c.1796C>T	c.(1795-1797)GCT>GTT	p.A599V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A599V	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	599	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGTTGACGCTGACTCAGGC	0.657													0	0	0	0.010504	0	21	79										T	140215764	C	T	140215764	3	4	88	1	0	0	0	0	1	0	0	0	11529	797	28	2	1798	2	PCDHA7	5	140215764	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	21427473	140215764	40699496	119	26317										
DCTN4	51164	broad.mit.edu	37	chr5	150097924	150097924	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gttctcaactggatttgtaaGagtcaggaggacctggctct	12	8	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:150097924G>C	uc003lsv.2	-	11	1087	c.985C>G	c.(985-987)CTT>GTT	p.L329V	DCTN4_uc003lsu.2_Missense_Mutation_p.L272V|DCTN4_uc010jhi.2_Missense_Mutation_p.L336V	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	329						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGATTTGTAAGAGTCAGGAGG	0.468													0	0	0	0.027356	0	26	19										C	150097924	G	C	150097924	3	2	88	1	0	0	0	0	1	0	0	0	4309	942	33	1	409	1	DCTN4	5	150097924	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	9882160	150097924	30817336	120	26318										
ODZ2	57451	broad.mit.edu	37	chr5	167517748	167517748	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgatggaaaagacaaagagaTggtttccttcaatactgttg	10	5	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:167517748T>A	uc010jjd.2	+	8	1685	c.1685T>A	c.(1684-1686)ATG>AAG	p.M562K	ODZ2_uc003lzq.2_Missense_Mutation_p.M441K|ODZ2_uc003lzr.3_Missense_Mutation_p.M330K|uc003lzs.1_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GACAAAGAGATGGTTTCCTTC	0.483													0	0	0	0.01441	0	41	147										A	167517748	T	A	167517748	3	1	88	1	0	0	0	0	1	0	0	0	10835	1464	51	5	1715	5	ODZ2	5	167517748	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	17419824	167517748	13397512	121	26319										
ODZ2	57451	broad.mit.edu	37	chr5	167631486	167631486	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcatttcctgtcccagctgCaacggccttgctgaaggcaa	10	13	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:167631486C>G	uc010jjd.2	+	19	3657	c.3657C>G	c.(3655-3657)TGC>TGG	p.C1219W	ODZ2_uc003lzr.3_Missense_Mutation_p.C996W|ODZ2_uc003lzt.3_Missense_Mutation_p.C592W|ODZ2_uc010jje.2_Missense_Mutation_p.C490W	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		GTCCCAGCTGCAACGGCCTTG	0.577													0	0	0	0.013537	0	11	50										G	167631486	C	G	167631486	3	3	88	1	0	0	0	0	1	0	0	0	10835	718	25	4	3731	4	ODZ2	5	167631486	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	113738	167631486	13283774	122	26320										
DOCK2	1794	broad.mit.edu	37	chr5	169122827	169122827	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gatcttggaaacaaagacctCaacagggataaaatttactt	7	7	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr5:169122827C>G	uc003maf.2	+	10	944	c.864C>G	c.(862-864)CTC>CTG	p.L288L	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	288					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACAAAGACCTCAACAGGGATA	0.433													0	0	0	0.008871	0	18	83										G	169122827	C	G	169122827	2	3	88	1	0	0	0	0	0	0	0	1	4687	813	29	1		1	DOCK2	5	169122827	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1491341	169122827	11792433	123	26321										
PRPF4B	8899	broad.mit.edu	37	chr6	4056655	4056655	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcttgtcagtagattttatcGtgctcctgaaatcagtaagt	8	7	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:4056655G>C	uc003mvv.2	+	12	2658	c.2567G>C	c.(2566-2568)CGT>CCT	p.R856P	PRPF4B_uc003mvw.2_RNA|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	856	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				AGATTTTATCGTGCTCCTGAA	0.383													0	0	0	0.012213	0	30	123										C	4056655	G	C	4056655	3	2	88	1	0	0	0	0	1	0	0	0	12573	1145	40	4	2613	4	PRPF4B	6	4056655	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		4056655	167058412	124	26322										
NEDD9	4739	broad.mit.edu	37	chr6	11185604	11185604	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatgtcctgggcagtcacctGccgtgtcagcgtgtctccaa	11	13	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:11185604G>A	uc003mzv.2	-	7	2463	c.2296C>T	c.(2296-2298)CAG>TAG	p.Q766*	NEDD9_uc010joz.2_Nonsense_Mutation_p.Q766*|NEDD9_uc003mzw.3_Nonsense_Mutation_p.Q620*	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	766					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCAGTCACCTGCCGTGTCAGC	0.557													0	0	0	0.012213	0	30	329										A	11185604	G	A	11185604	4	1	88	1	0	0	0	0	0	1	0	0	10313	1328	46	2	212	2	NEDD9	6	11185604	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7128949	11185604	159929463	125	26323										
DTNBP1	84062	broad.mit.edu	37	chr6	15663055	15663055	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtatacccacccggaggtgaAatcctgctgcacgctcagca	10	14	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:15663055A>T	uc003nbm.2	-	1	217	c.46T>A	c.(46-48)TTC>ATC	p.F16I	DTNBP1_uc003nbl.2_5'UTR|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA|DTNBP1_uc003nbp.2_Missense_Mutation_p.F16I|DTNBP1_uc010jph.2_5'UTR	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	16					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			CCGGAGGTGAAATCCTGCTGC	0.716									Hermansky-Pudlak_syndrome				0	0	0	0.024334	0	25	166										T	15663055	A	T	15663055	3	4	88	1	0	0	0	0	1	0	0	0	4790	14	1	5	1150	5	DTNBP1	6	15663055	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	4477451	15663055	155452012	126	26324										
HIST1H3E	8353	broad.mit.edu	37	chr6	26225674	26225674	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggcgctgcaggaggcctgcGaggcctacttggtggggctt	18	10	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:26225674G>A	uc003nhb.2	+	2	652	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST1H3E_uc003nhc.3_Missense_Mutation_p.E98K	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0223)|Acute lymphoblastic leukemia(11;0.0351)				GGAGGCCTGCGAGGCCTACTT	0.592											OREG0017240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	71	88										A	26225674	G	A	26225674	3	1	88	1	0	0	0	0	1	0	0	0	7159	1059	37	1	294	1	HIST1H3E	6	26225674	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	10562619	26225674	144889393	127	26325										
HIST1H1D	3007	broad.mit.edu	37	chr6	26234919	26234919	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aagctcttgaggccaagcttGatacggctgttgtttttttc	10	8	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:26234919G>C	uc003nhd.2	-	1	298	c.243C>G	c.(241-243)ATC>ATG	p.I81M		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	81	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GGCCAAGCTTGATACGGCTGT	0.542													0	0	0	0.01441	0	64	134										C	26234919	G	C	26234919	3	2	88	1	0	0	0	0	1	0	0	0	7125	1280	45	1	426	1	HIST1H1D	6	26234919	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	9245	26234919	144880148	128	26326										
SCAND3	114821	broad.mit.edu	37	chr6	28540437	28540437	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttgcagaaacactaagagttCatttcgtatttcaaacattc	5	8	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:28540437C>T	uc003nlo.2	-	4	3847	c.3229G>A	c.(3229-3231)GAA>AAA	p.E1077K		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1077					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						actaagagttcatttcgtatt	0													0	0	0	0.008361	0	30	104										T	28540437	C	T	28540437	3	4	88	1	0	0	0	0	1	0	0	0	13876	835	29	1	752	1	SCAND3	6	28540437	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2305518	28540437	142574630	129	26327										
HLA-A	3105	broad.mit.edu	37	chr6	29913231	29913231	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatatttttttctatagtgtGagacagctgccttgtgtggg	11	5	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:29913231G>C	uc003nol.2	+	8	1097	c.1097G>C	c.(1096-1098)TGA>TCA	p.*366S	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_5'Flank|HLA-A_uc003non.2_Nonstop_Mutation_p.*372S|HLA-A_uc003noo.2_Missense_Mutation_p.E367Q|HLA-A_uc010jrr.2_Nonstop_Mutation_p.*300S|HLA-A_uc003nom.2_Missense_Mutation_p.E244Q|HLA-A_uc011dmc.1_Nonstop_Mutation_p.*245S|HLA-A_uc011dmd.1_3'UTR	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	366					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCTATAGTGTGAGACAGCTGC	0.448									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			0	0	0	0.012319	0	19	65										C	29913231	G	C	29913231	4	2	88	1	0	0	0	0	0	0	0	0	7195	1285	45	1	1127	1	HLA-A	6	29913231	Nonstop_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1372794	29913231	141201836	130	26328										
BAT1	7919	broad.mit.edu	37	chr6	31500659	31500659	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aacccatgcagcgtcaacttCgtctcatcatccacgaagat	6	14	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:31500659C>T	uc003ntt.2	-	7	1396	c.765G>A	c.(763-765)ACG>ACA	p.T255T	BAT1_uc003ntq.2_5'Flank|BAT1_uc003ntr.2_Silent_p.T62T|BAT1_uc003nts.2_Silent_p.T255T|BAT1_uc011dnn.1_Silent_p.T177T|BAT1_uc003ntu.2_Silent_p.T255T|BAT1_uc003ntv.2_Silent_p.T255T	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	255					intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						GCGTCAACTTCGTCTCATCAT	0.388													0	0	0	0.007413	0	18	51										T	31500659	C	T	31500659	2	4	88	1	0	0	0	0	0	0	0	1	1318	871	31	1		1	BAT1	6	31500659	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1587428	31500659	139614408	131	26329										
BAT1	7919	broad.mit.edu	37	chr6	31503186	31503186	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	actggacggatctctttgctCaaggtagcactgaacatcat	9	10	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:31503186C>G	uc003ntt.2	-	6	1324	c.693G>C	c.(691-693)TTG>TTC	p.L231F	BAT1_uc003ntr.2_5'Flank|BAT1_uc003nts.2_Missense_Mutation_p.L231F|BAT1_uc011dnn.1_Missense_Mutation_p.L153F|BAT1_uc003ntu.2_Missense_Mutation_p.L231F|BAT1_uc003ntv.2_Missense_Mutation_p.L231F|BAT1_uc003ntw.2_Missense_Mutation_p.L231F|BAT1_uc003ntx.2_Missense_Mutation_p.L231F|BAT1_uc011dno.1_Missense_Mutation_p.L184F|BAT1_uc011dnp.1_Missense_Mutation_p.L153F	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	231	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						TCTCTTTGCTCAAGGTAGCAC	0.343													0	0	0	0.027356	0	24	110										G	31503186	C	G	31503186	3	3	88	1	0	0	0	0	1	0	0	0	1318	825	29	1	617	1	BAT1	6	31503186	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2527	31503186	139611881	132	26330										
TNXB	7148	broad.mit.edu	37	chr6	32053791	32053791	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caccctcaactctcccagctCctgggggcgctgctgcagga	11	17	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:32053791C>T	uc003nzl.2	-	7	3086	c.2884G>A	c.(2884-2886)GAG>AAG	p.E962K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1049	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCCCAGCTCCTGGGGGCGC	0.662													0	0	0	0.013537	0	13	18										T	32053791	C	T	32053791	3	4	88	1	0	0	0	0	1	0	0	0	16343	864	30	1	11981	1	TNXB	6	32053791	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	550605	32053791	139061276	133	26331										
PFDN6	10471	broad.mit.edu	37	chr6	33258524	33258524	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatcccagcttcgggatcttGagcggcagtcagagcaacag	12	11	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:33258524G>C	uc003odt.1	+	5	407	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	WDR46_uc003ods.2_5'Flank|WDR46_uc011dra.1_5'Flank|WDR46_uc010juo.1_5'Flank|PFDN6_uc010jup.1_Missense_Mutation_p.E98Q	NM_014260	NP_055075	O15212	PFD6_HUMAN	HLA class II region expressed gene KE2	98					'de novo' posttranslational protein folding|chaperone-mediated protein complex assembly	prefoldin complex	chaperone binding|unfolded protein binding				0						TCGGGATCTTGAGCGGCAGTC	0.562													0	0	0	0.00308	0	8	27										C	33258524	G	C	33258524	3	2	88	1	0	0	0	0	1	0	0	0	11759	1291	45	1	306	1	PFDN6	6	33258524	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1204733	33258524	137856543	134	26332										
HMGCLL1	54511	broad.mit.edu	37	chr6	55406532	55406532	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgtgggtttacatacctgtgGtacccatctggaagacacaa	10	9	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:55406532G>T	uc003pcn.2	-	4	541	c.382C>A	c.(382-384)CCA>ACA	p.P128T	HMGCLL1_uc003pco.2_Missense_Mutation_p.P98T|HMGCLL1_uc010jzx.2_5'UTR|HMGCLL1_uc011dxc.1_Missense_Mutation_p.P98T|HMGCLL1_uc011dxd.1_Missense_Mutation_p.P98T|HMGCLL1_uc011dxe.1_Missense_Mutation_p.P98T|HMGCLL1_uc003pcp.2_Missense_Mutation_p.P98T	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	128							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CATACCTGTGGTACCCATCTG	0.308													1	0	1.75199e-13	0.007291	1.87685e-13	28	125										T	55406532	G	T	55406532	3	4	88	1	0	0	0	0	1	0	0	0	7230	1261	44	4	758	4	HMGCLL1	6	55406532	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	22148008	55406532	115708535	135	26333										
NT5E	4907	broad.mit.edu	37	chr6	86200279	86200279	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgccctttggaggcacatttGacctagtccagttaaaaggt	10	9	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:86200279G>A	uc003pko.3	+	7	1820	c.1264G>A	c.(1264-1266)GAC>AAC	p.D422N	NT5E_uc010kbr.2_Intron	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	422					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	AGGCACATTTGACCTAGTCCA	0.517													0	0	0	0.014323	0	23	59										A	86200279	G	A	86200279	3	1	88	1	0	0	0	0	1	0	0	0	10693	1290	45	1	1290	1	NT5E	6	86200279	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	30793747	86200279	84914788	136	26334										
ORC3L	23595	broad.mit.edu	37	chr6	88321837	88321837	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catgaatttccactaatactCatttttggaatagccacatc	4	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:88321837C>G	uc003pmh.2	+	8	788	c.744C>G	c.(742-744)CTC>CTG	p.L248L	ORC3L_uc011dzl.1_Silent_p.L248L|ORC3L_uc011dzm.1_Silent_p.L248L|ORC3L_uc011dzn.1_RNA|ORC3L_uc003pmg.2_Silent_p.L248L|ORC3L_uc003pmi.2_Silent_p.L248L|ORC3L_uc011dzo.1_Silent_p.L105L|ORC3L_uc011dzp.1_Silent_p.L105L	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	248					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		CACTAATACTCATTTTTGGAA	0.328													0	0	0	0.012319	0	20	58										G	88321837	C	G	88321837	2	3	88	1	0	0	0	0	0	0	0	1	11263	813	29	1		1	ORC3L	6	88321837	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2121558	88321837	82793230	137	26335										
UBE2J1	51465	broad.mit.edu	37	chr6	90045107	90045107	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttttaaaggcaacaggacatCcttcatggcagagccacatc	8	11	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:90045107C>G	uc010kcb.2	-	7	645	c.472G>C	c.(472-474)GAT>CAT	p.D158H	UBE2J1_uc003pnc.2_Missense_Mutation_p.D158H	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	158	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		AACAGGACATCCTTCATGGCA	0.358													0	0	0	0.012319	0	21	54										G	90045107	C	G	90045107	3	3	88	1	0	0	0	0	1	0	0	0	16857	855	30	1	496	1	UBE2J1	6	90045107	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1723270	90045107	81069960	138	26336										
PRDM1	639	broad.mit.edu	37	chr6	106552838	106552838	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caaaggaaaggacctctaccGttctaacatttcacccctca	5	14	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:106552838G>A	uc003prd.2	+	5	1037	c.803G>A	c.(802-804)CGT>CAT	p.R268H	PRDM1_uc003pre.2_Missense_Mutation_p.R134H	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	268					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GACCTCTACCGTTCTAACATT	0.478			D|N|Mis|F|S		DLBCL								0	0	0	0.01441	0	83	734										A	106552838	G	A	106552838	3	1	88	1	0	0	0	0	1	0	0	0	12450	1145	40	2	834	2	PRDM1	6	106552838	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	16507731	106552838	64562229	139	26337										
PDSS2	57107	broad.mit.edu	37	chr6	107780282	107780282	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctcgtcgctcagcaggcagcGaaggctcatgaaggacgtgg	15	11	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:107780282G>T	uc003prt.2	-	1	498	c.208C>A	c.(208-210)CGC>AGC	p.R70S	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Missense_Mutation_p.R70S|PDSS2_uc003pru.2_Missense_Mutation_p.R70S|PDSS2_uc003prv.2_Missense_Mutation_p.R70S	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	70					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		AGCAGGCAGCGAAGGCTCATG	0.622											OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.86212e-05	0.008291	3.93576e-05	10	56										T	107780282	G	T	107780282	3	4	88	1	0	0	0	0	1	0	0	0	11694	1058	37	3	1023	3	PDSS2	6	107780282	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1227444	107780282	63334785	140	26338										
PDSS2	57107	broad.mit.edu	37	chr6	107780434	107780434	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accaccacaggcgacgcgggGaacccgaggctccaagataa	12	14	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:107780434G>A	uc003prt.2	-	1	346	c.56C>T	c.(55-57)TCC>TTC	p.S19F	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Missense_Mutation_p.S19F|PDSS2_uc003pru.2_Missense_Mutation_p.S19F|PDSS2_uc003prv.2_Missense_Mutation_p.S19F	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	19					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		GCGACGCGGGGAACCCGAGGC	0.617											OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	17	115										A	107780434	G	A	107780434	3	1	88	1	0	0	0	0	1	0	0	0	11694	1174	41	1	1175	1	PDSS2	6	107780434	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	152	107780434	63334633	141	26339										
REV3L	5980	broad.mit.edu	37	chr6	111628632	111628632	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaggatgactgcaacatgctGaggttggctccgacatttac	12	9	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:111628632G>A	uc003puy.3	-	31	9507	c.9184C>T	c.(9184-9186)CAG>TAG	p.Q3062*	REV3L_uc003pux.3_Nonsense_Mutation_p.Q2984*|REV3L_uc003puz.3_Nonsense_Mutation_p.Q2984*|REV3L_uc003puw.3_Nonsense_Mutation_p.Q129*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	3062					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCAACATGCTGAGGTTGGCTC	0.458								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.012213	0	28	98										A	111628632	G	A	111628632	4	1	88	1	0	0	0	0	0	1	0	0	13240	1299	45	1	216	1	REV3L	6	111628632	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3848198	111628632	59486435	142	26340										
RWDD1	51389	broad.mit.edu	37	chr6	116914146	116914146	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttggttgccttttgcagctgGaaacaacgtggaggtagatg	14	6	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:116914146G>C	uc003pxd.2	+	7	777	c.614G>C	c.(613-615)GGA>GCA	p.G205A	RWDD1_uc003pxb.2_Missense_Mutation_p.G109A|RWDD1_uc003pxc.2_Missense_Mutation_p.G109A	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	205							protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TTTGCAGCTGGAAACAACGTG	0.393													0	0	0	0.004482	0	7	44										C	116914146	G	C	116914146	3	2	88	1	0	0	0	0	1	0	0	0	13754	1174	41	1	640	1	RWDD1	6	116914146	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5285514	116914146	54200921	143	26341										
PTPRK	5796	broad.mit.edu	37	chr6	128291416	128291416	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agctacatcatagcagaaacGgtattgctcctgaaagatgt	9	8	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:128291416G>A	uc003qbk.2	-	30	4643	c.4276C>T	c.(4276-4278)CGT>TGT	p.R1426C	PTPRK_uc003qbj.2_Missense_Mutation_p.R1427C|PTPRK_uc010kfc.2_Missense_Mutation_p.R1433C|PTPRK_uc011ebu.1_Missense_Mutation_p.R1449C	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1426	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TAGCAGAAACGGTATTGCTCC	0.373													0	0	0	0.008871	0	19	59										A	128291416	G	A	128291416	3	1	88	1	0	0	0	0	1	0	0	0	12805	1116	39	2	47	2	PTPRK	6	128291416	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	11377270	128291416	42823651	144	26342										
PERP	64065	broad.mit.edu	37	chr6	138413346	138413346	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gacagcagggttggcatgaaGggtgaaggtctgggtgtact	18	5	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:138413346G>C	uc003qht.2	-	3	598	c.415C>G	c.(415-417)CTT>GTT	p.L139V		NM_022121	NP_071404	Q96FX8	PERP_HUMAN	PERP, TP53 apoptosis effector	139					apoptosis|cell adhesion	desmosome|Golgi apparatus|integral to membrane|nucleus					0	Breast(32;0.0799)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000878)|OV - Ovarian serous cystadenocarcinoma(155;0.000997)		TTGGCATGAAGGGTGAAGGTC	0.488													0	0	0	0.027356	0	26	102										C	138413346	G	C	138413346	3	2	88	1	0	0	0	0	1	0	0	0	11732	1000	35	4	170	4	PERP	6	138413346	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	10121930	138413346	32701721	145	26343										
FAM120B	84498	broad.mit.edu	37	chr6	170697422	170697423	+	Frame_Shift_Ins	INS	-	-	CG													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agctgggctcccttctcgtcINScgcggcctcaccactctggt							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr6:170697422_170697423insCG	uc003qxp.2	+	7	2439_2440	c.2331_2332insCG	c.(2329-2334)GTCCGCfs	p.V777fs	FAM120B_uc003qxo.1_Frame_Shift_Ins_p.V777fs|FAM120B_uc011ehd.1_Frame_Shift_Ins_p.V109fs|FAM120B_uc010kla.1_RNA	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	777_778					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)		CCCTTCTCGTCCGCGGCCTCAC	0.525																		17	53	---	---								CG	170697423	-	CG	170697422	7	5	88	1	0	1	1	0	0	0	0	0	5417	842	30	0	2353	0	FAM120B	6	170697422	Frame_Shift_Ins	INS	-	TCGA-FJ-A3Z7-01A-12D-A23M-08	32284076	170697422	417645	146	26344										
C7orf27	221927	broad.mit.edu	37	chr7	2583404	2583404	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgaccttgggggtggccgcgGagcacaaggactcttcaacg	15	11	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:2583404G>A	uc003smi.2	-	5	665	c.623C>T	c.(622-624)TCC>TTC	p.S208F	C7orf27_uc003smh.3_5'Flank|C7orf27_uc003smj.1_Missense_Mutation_p.S208F	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	208					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		GGTGGCCGCGGAGCACAAGGA	0.677													0	0	0	0.01441	0	44	149										A	2583404	G	A	2583404	3	1	88	1	0	0	0	0	1	0	0	0	2382	1174	41	1	1882	1	C7orf27	7	2583404	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		2583404	156555259	147	26345										
TNRC18	84629	broad.mit.edu	37	chr7	5353241	5353241	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cgtgtggcaggcatggtgatGaggggtgctggggccaggga	22	6	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:5353241G>C	uc003soi.3	-	27	7630	c.7281C>G	c.(7279-7281)CTC>CTG	p.L2427L		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2427	Pro-rich.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCATGGTGATGAGGGGTGCTG	0.721													0	0	0	0.024245	0	13	13										C	5353241	G	C	5353241	2	2	88	1	0	0	0	0	0	0	0	1	16336	1277	45	1		1	TNRC18	7	5353241	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2769837	5353241	153785422	148	26346										
PMS2	5395	broad.mit.edu	37	chr7	6043619	6043621	+	In_Frame_Del	DEL	TTC	TTC	-													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttacttaagccttcgaagttTtcttcttctaccccacatcc							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:6043619_6043621delTTC	uc003spl.2	-	3	319_321	c.232_234delGAA	c.(232-234)GAAdel	p.E78del	PMS2_uc003spj.2_In_Frame_Del_p.R6del|PMS2_uc003spk.2_5'UTR|PMS2_uc011jwl.1_5'UTR|PMS2_uc010ktg.2_5'UTR|PMS2_uc010kte.2_In_Frame_Del_p.E78del|PMS2_uc010ktf.1_In_Frame_Del_p.E78del	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	78					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTTCGAAGTTTTCTTCTTCTACC	0.31			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome									29	301	---	---								-	6043621	TTC	-	6043619	7	5	88	1	0	1	0	1	0	0	0	0	12143	1838	64	0	2406	0	PMS2	7	6043619	In_Frame_Del	DEL	TTC	TCGA-FJ-A3Z7-01A-12D-A23M-08	690378	6043619	153095044	149	26347										
RPA3	6119	broad.mit.edu	37	chr7	7676707	7676707	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcacagcttcattgtaaagtCcaagatctgaaagaaacatt	6	8	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:7676707C>G	uc003sri.2	-	8	1462	c.290G>C	c.(289-291)GGA>GCA	p.G97A	RPA3_uc003srh.2_Missense_Mutation_p.G58A	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	97					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		ATTGTAAAGTCCAAGATCTGA	0.303								Direct_reversal_of_damage|NER					0	0	0	0.00632	0	29	211										G	7676707	C	G	7676707	3	3	88	1	0	0	0	0	1	0	0	0	13538	855	30	1	79	1	RPA3	7	7676707	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1633088	7676707	151461956	150	26348										
DNAH11	8701	broad.mit.edu	37	chr7	21599258	21599258	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggataatacttcatgcaattGaatctgtggttattgaatgg	10	4	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:21599258G>T	uc003svc.2	+	4	761	c.730G>T	c.(730-732)GAA>TAA	p.E244*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	244	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCATGCAATTGAATCTGTGGT	0.338									Kartagener_syndrome				1	0	6.32553e-13	0.024334	6.7463e-13	25	34										T	21599258	G	T	21599258	4	4	88	1	0	0	0	0	0	1	0	0	4599	1291	45	3	744	3	DNAH11	7	21599258	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	13922551	21599258	137539405	151	26349										
CCDC129	223075	broad.mit.edu	37	chr7	31611746	31611746	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagttttcagaaactcccatCctatccagagggaccagttt	7	12	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:31611746C>T	uc003tcj.1	+	6	1332	c.339C>T	c.(337-339)ATC>ATT	p.I113I	CCDC129_uc011kad.1_Silent_p.I123I|CCDC129_uc003tci.1_Silent_p.I112I|CCDC129_uc011kae.1_Silent_p.I139I|CCDC129_uc003tck.1_Silent_p.I21I	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	113											0						AAACTCCCATCCTATCCAGAG	0.398													0	0	0	0.016723	0	10	82										T	31611746	C	T	31611746	2	4	88	1	0	0	0	0	0	0	0	1	2764	845	30	1		1	CCDC129	7	31611746	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10012488	31611746	127526917	152	26350										
BBS9	27241	broad.mit.edu	37	chr7	33545228	33545228	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctattctggaagcggcatttCtgccgctacaagaagacact	9	11	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:33545228C>G	uc003tdn.1	+	20	2782	c.2269C>G	c.(2269-2271)CTG>GTG	p.L757V	BBS9_uc003tdo.1_Missense_Mutation_p.L722V|BBS9_uc003tdp.1_Missense_Mutation_p.L752V|BBS9_uc003tdq.1_Missense_Mutation_p.L717V|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.L281V|BBS9_uc003tds.1_Missense_Mutation_p.L180V|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	757					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			AGCGGCATTTCTGCCGCTACA	0.488									Bardet-Biedl_syndrome				0	0	0	0.004007	0	17	136										G	33545228	C	G	33545228	3	3	88	1	0	0	0	0	1	0	0	0	1342	912	32	1	2343	1	BBS9	7	33545228	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1933482	33545228	125593435	153	26351										
GLI3	2737	broad.mit.edu	37	chr7	42005585	42005585	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccatcgccggggggttgcagCtgctgaggctgctgaagcgc	17	12	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:42005585C>T	uc011kbh.1	-	15	3177	c.3086G>A	c.(3085-3087)AGC>AAC	p.S1029N	GLI3_uc011kbg.1_Missense_Mutation_p.S970N	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1029					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GGGGTTGCAGCTGCTGAGGCT	0.711									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.021553	0	5	25										T	42005585	C	T	42005585	3	4	88	1	0	0	0	0	1	0	0	0	6439	797	28	2	1660	2	GLI3	7	42005585	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	8460357	42005585	117133078	154	26352										
GLI3	2737	broad.mit.edu	37	chr7	42005604	42005604	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gctgctgaggctgctgaagcGcggcacacgaggcagggcca	17	12	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:42005604G>A	uc011kbh.1	-	15	3158	c.3067C>T	c.(3067-3069)CGC>TGC	p.R1023C	GLI3_uc011kbg.1_Missense_Mutation_p.R964C	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1023					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGCTGAAGCGCGGCACACGA	0.731									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.014758	0	4	22										A	42005604	G	A	42005604	3	1	88	1	0	0	0	0	1	0	0	0	6439	1087	38	2	1679	2	GLI3	7	42005604	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	19	42005604	117133059	155	26353										
ABCA13	154664	broad.mit.edu	37	chr7	48266924	48266924	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctccatcagcagcctcatatCtgggattttctacttttact	5	12	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:48266924C>G	uc003toq.2	+	6	559	c.534C>G	c.(532-534)ATC>ATG	p.I178M	ABCA13_uc003top.2_Missense_Mutation_p.I178M|ABCA13_uc010kyr.2_Translation_Start_Site	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	178					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AGCCTCATATCTGGGATTTTC	0.428													0	0	0	0.013726	0	32	135										G	48266924	C	G	48266924	3	3	88	1	0	0	0	0	1	0	0	0	31	903	32	1	385	1	ABCA13	7	48266924	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6261320	48266924	110871739	156	26354										
ABCA13	154664	broad.mit.edu	37	chr7	48349571	48349571	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcagtgccctcaccgtagctCtgtctggaaagtgtgatcag	11	11	5	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:48349571C>T	uc003toq.2	+	24	9374	c.9349C>T	c.(9349-9351)CTG>TTG	p.L3117L	ABCA13_uc010kys.1_Silent_p.L191L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3117					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CACCGTAGCTCTGTCTGGAAA	0.502													0	0	0	0.010504	0	21	105										T	48349571	C	T	48349571	2	4	88	1	0	0	0	0	0	0	0	1	31	912	32	1		1	ABCA13	7	48349571	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	82647	48349571	110789092	157	26355										
AUTS2	26053	broad.mit.edu	37	chr7	70249966	70249966	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggaccccttttgggccacctCctcatcacagcaacttcctc	6	18	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:70249966C>G	uc003tvw.3	+	16	2928	c.2185C>G	c.(2185-2187)CCT>GCT	p.P729A	AUTS2_uc003tvx.3_Missense_Mutation_p.P705A|AUTS2_uc011keg.1_Missense_Mutation_p.P181A	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	729										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TGGGCCACCTCCTCATCACAG	0.507													0	0	0	0.00499	0	14	62										G	70249966	C	G	70249966	3	3	88	1	0	0	0	0	1	0	0	0	1225	855	30	1	2392	1	AUTS2	7	70249966	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	21900395	70249966	88888697	158	26356										
GTF2IRD1	9569	broad.mit.edu	37	chr7	73933956	73933956	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gagagctcaagcaggaagcaCcttcctgcccccttgccccc	9	18	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:73933956C>G	uc003uaq.2	+	6	1216	c.823C>G	c.(823-825)CCT>GCT	p.P275A	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.P307A|GTF2IRD1_uc003uap.2_Missense_Mutation_p.P275A|GTF2IRD1_uc003uar.1_Missense_Mutation_p.P275A	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	275						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						GCAGGAAGCACCTTCCTGCCC	0.657													0	0	0	0.013537	0	13	55										G	73933956	C	G	73933956	3	3	88	1	0	0	0	0	1	0	0	0	6868	507	18	4	841	4	GTF2IRD1	7	73933956	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3683990	73933956	85204707	159	26357										
ABCB4	5244	broad.mit.edu	37	chr7	87072646	87072646	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cccacttactgtgccctcatCagggtcatagagcctctgta	8	14	4	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:87072646C>T	uc003uiv.1	-	12	1421	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	ABCB4_uc003uiw.1_Missense_Mutation_p.D449N|ABCB4_uc003uix.1_Missense_Mutation_p.D449N	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	449	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GTGCCCTCATCAGGGTCATAG	0.507													0	0	0	0.01441	0	83	268										T	87072646	C	T	87072646	3	4	88	1	0	0	0	0	1	0	0	0	43	826	29	1	2583	1	ABCB4	7	87072646	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	13138690	87072646	72066017	160	26358										
STAG3	10734	broad.mit.edu	37	chr7	99783835	99783835	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttccctagtctttggtagatGagtggctggatagctacaag	12	7	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:99783835G>C	uc003utx.1	+	5	504	c.349G>C	c.(349-351)GAG>CAG	p.E117Q	STAG3_uc010lgs.1_5'UTR|STAG3_uc011kjk.1_Intron	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	117					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTTGGTAGATGAGTGGCTGGA	0.284													0	0	0	0.017118	0	30	197										C	99783835	G	C	99783835	3	2	88	1	0	0	0	0	1	0	0	0	15243	1291	45	1	363	1	STAG3	7	99783835	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	12711189	99783835	59354828	161	26359										
CDHR3	222256	broad.mit.edu	37	chr7	105672957	105672957	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggagctgccccacgcagagtCactgctggggaagggatggg	18	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:105672957C>T	uc003vdl.3	+	19	2580	c.2472C>T	c.(2470-2472)GTC>GTT	p.V824V	CDHR3_uc003vdk.2_3'UTR|CDHR3_uc003vdm.3_Silent_p.V811V|CDHR3_uc011klt.1_Silent_p.V736V|CDHR3_uc003vdn.2_3'UTR	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	824	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CACGCAGAGTCACTGCTGGGG	0.532													0	0	0	0.006122	0	16	22										T	105672957	C	T	105672957	2	4	88	1	0	0	0	0	0	0	0	1	3120	813	29	1		1	CDHR3	7	105672957	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5889122	105672957	53465706	162	26360										
SLC26A4	5172	broad.mit.edu	37	chr7	107315425	107315425	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttgcagattggattcatagtGaggtacttggcagatccttt	11	6	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:107315425G>A	uc003vep.2	+	6	860	c.636G>A	c.(634-636)GTG>GTA	p.V212V		NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	212	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						GATTCATAGTGAGGTACTTGG	0.413									Pendred_syndrome				0	0	0	0.01441	0	57	181										A	107315425	G	A	107315425	2	1	88	1	0	0	0	0	0	0	0	1	14519	1277	45	1		1	SLC26A4	7	107315425	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1642468	107315425	51823238	163	26361										
PPP1R3A	5506	broad.mit.edu	37	chr7	113518587	113518587	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgaagttgctttttgatattCtgtaatgacccatgaggatt	9	5	1	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:113518587C>T	uc010ljy.1	-	4	2591	c.2560G>A	c.(2560-2562)GAA>AAA	p.E854K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	854					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TTTTGATATTCTGTAATGACC	0.378													0	0	0	0.025465	0	38	150										T	113518587	C	T	113518587	3	4	88	1	0	0	0	0	1	0	0	0	12371	922	32	1	812	1	PPP1R3A	7	113518587	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6203162	113518587	45620076	164	26362										
ZNF777	27153	broad.mit.edu	37	chr7	149152502	149152502	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccttccagggtcagtagcctCatggcctgggcctccagctt	11	15	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:149152502C>T	uc003wfv.2	-	2	775	c.612G>A	c.(610-612)ATG>ATA	p.M204I		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCAGTAGCCTCATGGCCTGGG	0.602													0	0	0	0.024334	0	27	102										T	149152502	C	T	149152502	3	4	88	1	0	0	0	0	1	0	0	0	18147	826	29	1	1903	1	ZNF777	7	149152502	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	35633915	149152502	9986161	165	26363										
PTPRN2	5799	broad.mit.edu	37	chr7	157926662	157926662	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gacttcttcctctccatgtcGaggggccttgcaaaggggag	13	11	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:157926662G>C	uc003wno.2	-	9	1384	c.1263C>G	c.(1261-1263)CTC>CTG	p.L421L	PTPRN2_uc003wnp.2_Silent_p.L404L|PTPRN2_uc003wnq.2_Silent_p.L421L|PTPRN2_uc003wnr.2_Silent_p.L383L|PTPRN2_uc011kwa.1_Silent_p.L444L	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	421	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TCTCCATGTCGAGGGGCCTTG	0.592													0	0	0	0.010818	0	31	81										C	157926662	G	C	157926662	2	2	88	1	0	0	0	0	0	0	0	1	12808	1045	37	1		1	PTPRN2	7	157926662	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	8774160	157926662	1212001	166	26364										
WDR60	55112	broad.mit.edu	37	chr7	158718985	158718985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgctttcacccttttctactCaagaaggtacgtgattcttc	6	11	4	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr7:158718985C>G	uc003woe.3	+	18	2523	c.2365C>G	c.(2365-2367)CAA>GAA	p.Q789E	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_Missense_Mutation_p.Q421E	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	789	WD 2.									ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		CTTTTCTACTCAAGAAGGTAC	0.393													0	0	0	0.004672	0	3	18										G	158718985	C	G	158718985	3	3	88	1	0	0	0	0	1	0	0	0	17308	827	29	1	2435	1	WDR60	7	158718985	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	792323	158718985	419678	167	26365										
MYOM2	9172	broad.mit.edu	37	chr8	2057272	2057272	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aggctgagcacttatcaccaGatgccagctaccgatttatt	8	11	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:2057272G>A	uc003wpx.3	+	25	3268	c.3130G>A	c.(3130-3132)GAT>AAT	p.D1044N	MYOM2_uc011kwi.1_Missense_Mutation_p.D469N	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1044					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTTATCACCAGATGCCAGCTA	0.463													0	0	0	0.021022	0	37	45										A	2057272	G	A	2057272	3	1	88	1	0	0	0	0	1	0	0	0	10092	942	33	1	3224	1	MYOM2	8	2057272	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		2057272	144306750	168	26366										
SPAG11B	10407	broad.mit.edu	37	chr8	7308402	7308402	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catatggcagatggtatttcTaattcccggtggaacatccc	9	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:7308402T>C	uc003wrk.2	-	4	478	c.311A>G	c.(310-312)TAG>TGG	p.*104W	SPAG11B_uc003wrg.1_Missense_Mutation_p.R79G|SPAG11B_uc003wrh.1_Intron|SPAG11B_uc003wri.2_Nonstop_Mutation_p.*51W|SPAG11B_uc003wrj.2_Missense_Mutation_p.R26G|SPAG11B_uc003wrl.2_Missense_Mutation_p.R79G	NM_016512	NP_057596	Q08648	SG11B_HUMAN	sperm associated antigen 11B isoform A	104					spermatogenesis	extracellular region					0				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		ATGGTATTTCTAATTCCCGGT	0.458													0	0	0	0.014323	0	22	64										C	7308402	T	C	7308402	4	2	88	1	0	0	0	0	0	0	0	0	14977	1535	53	5	209	5	SPAG11B	8	7308402	Nonstop_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	5251130	7308402	139055620	169	26367										
SGK223	157285	broad.mit.edu	37	chr8	8197120	8197120	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctggctcactttttccaaatCagagctgctcttgttcattt	6	11	4	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:8197120C>G	uc003wsh.3	-	3	2188	c.2188G>C	c.(2188-2190)GAT>CAT	p.D730H		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	730							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TTTTCCAAATCAGAGCTGCTC	0.498													0	0	0	0.015359	0	32	56										G	8197120	C	G	8197120	3	3	88	1	0	0	0	0	1	0	0	0	14210	826	29	1	2032	1	SGK223	8	8197120	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	888718	8197120	138166902	170	26368										
PRKDC	5591	broad.mit.edu	37	chr8	48805803	48805803	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catagcgtggcctgcaggctGaatggcccccgaagtacaag	13	12	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:48805803G>A	uc003xqi.2	-	32	3801	c.3744C>T	c.(3742-3744)TTC>TTT	p.F1248F	PRKDC_uc003xqj.2_Silent_p.F1248F|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1248					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCTGCAGGCTGAATGGCCCCC	0.617								NHEJ					0	0	0	0.014758	0	5	26										A	48805803	G	A	48805803	2	1	88	1	0	0	0	0	0	0	0	1	12521	1294	45	1		1	PRKDC	8	48805803	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	40608683	48805803	97558219	171	26369										
PXDNL	137902	broad.mit.edu	37	chr8	52339252	52339252	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gttctccttgagcatgacatGaaatgtttatattctttcca	6	8	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:52339252G>A	uc003xqu.3	-	13	1693	c.1592C>T	c.(1591-1593)TCA>TTA	p.S531L		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	531	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGCATGACATGAAATGTTTAT	0.358													0	0	0	0.021553	0	5	31										A	52339252	G	A	52339252	3	1	88	1	0	0	0	0	1	0	0	0	12848	1294	45	1	2843	1	PXDNL	8	52339252	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3533449	52339252	94024770	172	26370										
CLVS1	157807	broad.mit.edu	37	chr8	62371083	62371083	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaatctggagagagaatgctCacccaagctgatgaaaaggt	12	7	2	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:62371083C>T	uc003xuh.2	+	5	1283	c.959C>T	c.(958-960)TCA>TTA	p.S320L	CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Intron	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	320					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						AGAGAATGCTCACCCAAGCTG	0.443													0	0	0	0.004007	0	14	32										T	62371083	C	T	62371083	3	4	88	1	0	0	0	0	1	0	0	0	3571	838	29	1	973	1	CLVS1	8	62371083	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10031831	62371083	83992939	173	26371										
TRIM55	84675	broad.mit.edu	37	chr8	67047319	67047319	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcgaagtacccacctgctctCtgtgcaaggtgtttggtgca	12	11	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:67047319C>T	uc003xvv.2	+	3	662	c.436C>T	c.(436-438)CTG>TTG	p.L146L	TRIM55_uc003xvu.2_Silent_p.L146L|TRIM55_uc003xvw.2_Silent_p.L146L|TRIM55_uc003xvx.2_Silent_p.L146L	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	146						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CACCTGCTCTCTGTGCAAGGT	0.547													0	0	0	0.00499	0	17	126										T	67047319	C	T	67047319	2	4	88	1	0	0	0	0	0	0	0	1	16526	912	32	1		1	TRIM55	8	67047319	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4676236	67047319	79316703	174	26372										
NCOA2	10499	broad.mit.edu	37	chr8	71053436	71053436	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tacctatattcatgacctgaGactgaagcgtctgtctttgg	9	9	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:71053436G>C	uc003xyn.1	-	14	3173	c.3011C>G	c.(3010-3012)TCT>TGT	p.S1004C	NCOA2_uc011lfb.1_Missense_Mutation_p.S92C	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1004					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			CATGACCTGAGACTGAAGCGT	0.498			T	RUNXBP2	AML								0	0	0	0.021553	0	6	55										C	71053436	G	C	71053436	3	2	88	1	0	0	0	0	1	0	0	0	10229	942	33	1	1423	1	NCOA2	8	71053436	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4006117	71053436	75310586	175	26373										
ZFHX4	79776	broad.mit.edu	37	chr8	77766597	77766597	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccactgcaaatttccatgacGtctctccagaacagtctacc	5	15	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:77766597G>A	uc003yav.2	+	10	7692	c.7305G>A	c.(7303-7305)ACG>ACA	p.T2435T	ZFHX4_uc003yau.1_Silent_p.T2480T|ZFHX4_uc003yaw.1_Silent_p.T2435T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2435						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTTCCATGACGTCTCTCCAGA	0.458										HNSCC(33;0.089)			0	0	0	0.01441	0	117	22										A	77766597	G	A	77766597	2	1	88	1	0	0	0	0	0	0	0	1	17632	1132	40	2		2	ZFHX4	8	77766597	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6713161	77766597	68597425	176	26374										
CSMD3	114788	broad.mit.edu	37	chr8	113318315	113318315	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtagtgagttctttggatgaCaatcgatatccatcattaca	8	7	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr8:113318315C>A	uc003ynu.2	-	51	8151	c.7992G>T	c.(7990-7992)TTG>TTT	p.L2664F	CSMD3_uc003yns.2_Missense_Mutation_p.L1866F|CSMD3_uc003ynt.2_Missense_Mutation_p.L2624F|CSMD3_uc011lhx.1_Missense_Mutation_p.L2560F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2664	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTTGGATGACAATCGATATC	0.418										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	5.8336e-16	0.015359	6.36273e-16	33	106										A	113318315	C	A	113318315	3	1	88	1	0	0	0	0	1	0	0	0	3946	477	17	4	3215	4	CSMD3	8	113318315	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	35551718	113318315	33045707	177	26375										
TTC39B	158219	broad.mit.edu	37	chr9	15188001	15188001	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	actctctttgcaaagcagatCtgaatagtaatatgcctgca	7	9	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:15188001C>G	uc003zlr.1	-	14	1286	c.1165G>C	c.(1165-1167)GAT>CAT	p.D389H	TTC39B_uc003zlq.1_Missense_Mutation_p.D358H|TTC39B_uc011lmp.1_Missense_Mutation_p.D290H|TTC39B_uc010mie.1_Missense_Mutation_p.D387H|TTC39B_uc011lmq.1_Missense_Mutation_p.D376H|TTC39B_uc011lmr.1_Missense_Mutation_p.D320H|TTC39B_uc010mif.1_Missense_Mutation_p.D389H|TTC39B_uc003zls.1_Missense_Mutation_p.D290H|TTC39B_uc010mig.1_Missense_Mutation_p.D358H|TTC39B_uc003zlp.1_5'UTR	NM_152574	NP_689787	Q5VTQ0	TT39B_HUMAN	tetratricopeptide repeat domain 39B	389							binding			ovary(1)	1						CAAAGCAGATCTGAATAGTAA	0.373													0	0	0	0.008361	0	25	100										G	15188001	C	G	15188001	3	3	88	1	0	0	0	0	1	0	0	0	16705	913	32	1	713	1	TTC39B	9	15188001	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		15188001	126025430	178	26376										
BNC2	54796	broad.mit.edu	37	chr9	16437085	16437085	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	taaggtgtgggagaaacttcGgattcgctgctctcattata	11	7	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:16437085G>A	uc003zml.2	-	6	1247	c.1107C>T	c.(1105-1107)TCC>TCT	p.S369S	BNC2_uc011lmw.1_Silent_p.S274S|BNC2_uc003zmm.2_Silent_p.S327S|BNC2_uc003zmq.1_Silent_p.S383S|BNC2_uc003zmr.1_Silent_p.S406S|BNC2_uc003zmp.1_Silent_p.S397S|BNC2_uc010mij.1_Silent_p.S291S|BNC2_uc011lmv.1_Silent_p.S195S|BNC2_uc003zmo.1_Silent_p.S291S|BNC2_uc003zmj.2_Silent_p.S134S|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.S134S|BNC2_uc003zmn.1_Silent_p.S134S	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GAGAAACTTCGGATTCGCTGC	0.483													0	0	0	0.024245	0	14	138										A	16437085	G	A	16437085	2	1	88	1	0	0	0	0	0	0	0	1	1475	1103	39	2		2	BNC2	9	16437085	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1249084	16437085	124776346	179	26377										
MLLT3	4300	broad.mit.edu	37	chr9	20414109	20414109	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gccatcttaggaactattttCtcttctttcagtggtttatt	6	8	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:20414109C>G	uc003zoe.2	-	5	994	c.735G>C	c.(733-735)GAG>GAC	p.E245D	MLLT3_uc011lne.1_Missense_Mutation_p.E213D|MLLT3_uc011lnf.1_Missense_Mutation_p.E242D|MLLT3_uc003zof.2_Missense_Mutation_p.E46D	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		GAACTATTTTCTCTTCTTTCA	0.388			T	MLL	ALL								0	0	0	0.01441	0	65	210										G	20414109	C	G	20414109	3	3	88	1	0	0	0	0	1	0	0	0	9628	912	32	1	999	1	MLLT3	9	20414109	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3977024	20414109	120799322	180	26378										
MSMP	692094	broad.mit.edu	37	chr9	35754000	35754000	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcttcaccccactttaccttGagcttggaagtagcacttgc	8	13	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:35754000G>C	uc003zyb.1	-	1	273	c.127C>G	c.(127-129)CAA>GAA	p.Q43E		NM_001044264	NP_001037729	Q1L6U9	MSMP_HUMAN	PC3-secreted microprotein precursor	43						extracellular region					0						ACTTTACCTTGAGCTTGGAAG	0.552													0	0	0	0.01441	0	428	245										C	35754000	G	C	35754000	3	2	88	1	0	0	0	0	1	0	0	0	9884	1299	45	1	304	1	MSMP	9	35754000	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	15339891	35754000	105459431	181	26379										
FLJ46321	389763	broad.mit.edu	37	chr9	84607086	84607086	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctacccttgcctcaaaccctGccccaaggtcagtccccaca	5	20	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:84607086G>A	uc004amn.2	+	4	1748	c.1701G>A	c.(1699-1701)CTG>CTA	p.L567L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	567						integral to membrane					0						CTCAAACCCTGCCCCAAGGTC	0.517													0	0	0	0.024334	0	25	122										A	84607086	G	A	84607086	2	1	88	1	0	0	0	0	0	0	0	1	5932	1306	46	2		2	FLJ46321	9	84607086	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	48853086	84607086	56606345	182	26380										
SPIN1	10927	broad.mit.edu	37	chr9	91090081	91090081	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tatgccaaagaagatggctcGaaaaggactggcatggtcat	12	7	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:91090081G>A	uc010mqj.2	+	6	1178	c.678G>A	c.(676-678)TCG>TCA	p.S226S	SPIN1_uc004apy.2_Silent_p.S226S|SPIN1_uc004apz.2_Silent_p.S226S|SPIN1_uc010mqk.2_Silent_p.S226S	NM_006717	NP_006708	Q9Y657	SPIN1_HUMAN	spindlin	226					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0						AAGATGGCTCGAAAAGGACTG	0.418													0	0	0	0.012319	0	21	103										A	91090081	G	A	91090081	2	1	88	1	0	0	0	0	0	0	0	1	15051	1045	37	1		1	SPIN1	9	91090081	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6482995	91090081	50123350	183	26381										
WNK2	65268	broad.mit.edu	37	chr9	96015214	96015214	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tctaccgtgtactcagactcGcagagcagccagcagagcgt	11	13	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:96015214G>A	uc004ati.1	+	8	1884	c.1884G>A	c.(1882-1884)TCG>TCA	p.S628S	WNK2_uc011lud.1_Silent_p.S628S|WNK2_uc004atj.2_Silent_p.S628S|WNK2_uc004atk.2_Silent_p.S265S|WNK2_uc010mrc.1_Silent_p.S628S	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	628					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						ACTCAGACTCGCAGAGCAGCC	0.642													0	0	0	0.009096	0	4	3										A	96015214	G	A	96015214	2	1	88	1	0	0	0	0	0	0	0	1	17375	1074	38	2		2	WNK2	9	96015214	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4925133	96015214	45198217	184	26382										
KIAA1529	57653	broad.mit.edu	37	chr9	100079409	100079409	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagctgtttgtcaacctgatGgagtccaccctgcagcagga	11	12	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:100079409G>A	uc011lut.1	+	21	2180	c.1407G>A	c.(1405-1407)ATG>ATA	p.M469I	KIAA1529_uc004axe.1_Missense_Mutation_p.M469I|KIAA1529_uc004axg.1_Missense_Mutation_p.M330I|KIAA1529_uc011lus.1_Missense_Mutation_p.M287I|KIAA1529_uc010msm.1_RNA|KIAA1529_uc004axf.2_Missense_Mutation_p.M330I|KIAA1529_uc011luv.1_Missense_Mutation_p.M327I	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				TCAACCTGATGGAGTCCACCC	0.612													0	0	0	0.008361	0	30	125										A	100079409	G	A	100079409	3	1	88	1	0	0	0	0	1	0	0	0	8240	1348	47	2	1453	2	KIAA1529	9	100079409	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4064195	100079409	41134022	185	26383										
MURC	347273	broad.mit.edu	37	chr9	103348232	103348232	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaggagcacattgataatatCaagaaggcattttccaaaga	8	6	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:103348232C>T	uc004bba.2	+	2	684	c.594C>T	c.(592-594)ATC>ATT	p.I198I		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	198					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				TTGATAATATCAAGAAGGCAT	0.423													0	0	0	0.01441	0	72	39										T	103348232	C	T	103348232	2	4	88	1	0	0	0	0	0	0	0	1	9987	816	29	1		1	MURC	9	103348232	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3268823	103348232	37865199	186	26384										
ZNF189	7743	broad.mit.edu	37	chr9	104171809	104171809	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcgcagtcttgtcaaccatCagaagatccatgcagaggtg	11	10	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:104171809C>T	uc004bbh.1	+	3	2035	c.1759C>T	c.(1759-1761)CAG>TAG	p.Q587*	ZNF189_uc004bbg.1_Nonsense_Mutation_p.Q545*|ZNF189_uc004bbi.1_Nonsense_Mutation_p.Q573*|ZNF189_uc011lvk.1_Nonsense_Mutation_p.Q572*	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	587	C2H2-type 15.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				TGTCAACCATCAGAAGATCCA	0.423													0	0	0	0.01892	0	25	55										T	104171809	C	T	104171809	4	4	88	1	0	0	0	0	0	1	0	0	17751	827	29	1	1769	1	ZNF189	9	104171809	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	823577	104171809	37041622	187	26385										
C9orf5	23731	broad.mit.edu	37	chr9	111812856	111812856	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctatgtggacgtaccagagaGagtacaaaattgagaagggc	13	6	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:111812856G>C	uc004bdt.3	-	13	2003	c.1971C>G	c.(1969-1971)CTC>CTG	p.L657L	C9orf5_uc004bds.3_RNA|C9orf5_uc004bdr.3_Silent_p.L649L	NM_032012	NP_114401	Q9H330	CI005_HUMAN	hypothetical protein LOC23731	657	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1		Myeloproliferative disorder(63;0.204)		OV - Ovarian serous cystadenocarcinoma(323;3.08e-05)|STAD - Stomach adenocarcinoma(157;0.0823)		GTACCAGAGAGAGTACAAAAT	0.443													0	0	0	0.00499	0	15	76										C	111812856	G	C	111812856	2	2	88	1	0	0	0	0	0	0	0	1	2486	929	33	1		1	C9orf5	9	111812856	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7641047	111812856	29400575	188	26386										
SUSD1	64420	broad.mit.edu	37	chr9	114904756	114904756	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gatatagccatctggaacctCaggaggggtaccacagtcta	11	10	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:114904756C>T	uc004bfu.2	-	5	591	c.550G>A	c.(550-552)GAG>AAG	p.E184K	SUSD1_uc010mui.2_Missense_Mutation_p.E184K|SUSD1_uc010muj.2_Missense_Mutation_p.E184K	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	184	Sushi 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						TCTGGAACCTCAGGAGGGGTA	0.398													0	0	0	0.01441	0	111	82										T	114904756	C	T	114904756	3	4	88	1	0	0	0	0	1	0	0	0	15404	835	29	1	1745	1	SUSD1	9	114904756	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3091900	114904756	26308675	189	26387										
TLR4	7099	broad.mit.edu	37	chr9	120475327	120475327	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	attgacttatttaattgtttGacaaatgtttcttcattttc	4	5	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:120475327G>C	uc004bjz.2	+	3	1212	c.921G>C	c.(919-921)TTG>TTC	p.L307F	TLR4_uc004bka.2_Missense_Mutation_p.L267F|TLR4_uc004bkb.2_Missense_Mutation_p.L107F	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	307	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTAATTGTTTGACAAATGTTT	0.338													0	0	0	0.008361	0	30	106										C	120475327	G	C	120475327	3	2	88	1	0	0	0	0	1	0	0	0	15950	1281	45	1	931	1	TLR4	9	120475327	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5570571	120475327	20738104	190	26388										
WDR38	401551	broad.mit.edu	37	chr9	127617983	127617983	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcctcctgtgactgcactgtCcgcctgtgggatgtggcaag	14	12	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:127617983C>T	uc004box.2	+	3	317	c.261C>T	c.(259-261)GTC>GTT	p.V87V	WDR38_uc011lzn.1_Silent_p.V76V|WDR38_uc011lzo.1_Silent_p.V87V|WDR38_uc011lzp.1_Intron	NM_001045476	NP_001038941	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	87	WD 2.										0						ACTGCACTGTCCGCCTGTGGG	0.642											OREG0019485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	77										T	127617983	C	T	127617983	2	4	88	1	0	0	0	0	0	0	0	1	17289	842	30	1		1	WDR38	9	127617983	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	7142656	127617983	13595448	191	26389										
PTGES2	80142	broad.mit.edu	37	chr9	130887585	130887585	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtaggaggagaacttgatctCagccctgcgcacagggttca	13	10	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:130887585C>G	uc004bti.2	-	2	893	c.415G>C	c.(415-417)GAG>CAG	p.E139Q	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_5'UTR|PTGES2_uc004btl.2_5'UTR|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	139	Glutaredoxin.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						AACTTGATCTCAGCCCTGCGC	0.602													0	0	0	0.006122	0	18	8										G	130887585	C	G	130887585	3	3	88	1	0	0	0	0	1	0	0	0	12747	835	29	1	742	1	PTGES2	9	130887585	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3269602	130887585	10325846	192	26390										
PTGES2	80142	broad.mit.edu	37	chr9	130887694	130887694	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtcttgtactggtacagggtCagctgcaggcggctggacag	16	9	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:130887694C>T	uc004bti.2	-	2	784	c.306G>A	c.(304-306)CTG>CTA	p.L102L	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_5'UTR|PTGES2_uc004btl.2_5'UTR|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	102	Glutaredoxin.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						GGTACAGGGTCAGCTGCAGGC	0.637													0	0	0	0.023175	0	35	23										T	130887694	C	T	130887694	2	4	88	1	0	0	0	0	0	0	0	1	12747	813	29	1		1	PTGES2	9	130887694	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	109	130887694	10325737	193	26391										
MED27	9442	broad.mit.edu	37	chr9	134889766	134889766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgggctgagcctttggtctaCgtttggcagatactcccatc	11	11	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr9:134889766C>T	uc004cbe.1	-	3	459	c.437G>A	c.(436-438)CGT>CAT	p.R146H	MED27_uc004cbf.1_Missense_Mutation_p.R146H|MED27_uc011mco.1_Missense_Mutation_p.R146H|MED27_uc004cbg.3_Missense_Mutation_p.R146H	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	mediator complex subunit 27	146					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity			skin(1)	1		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		CTTTGGTCTACGTTTGGCAGA	0.428													0	0	0	0.024334	0	24	73										T	134889766	C	T	134889766	3	4	88	1	0	0	0	0	1	0	0	0	9445	536	19	2	522	2	MED27	9	134889766	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4002072	134889766	6323665	194	26392										
AKR1E2	83592	broad.mit.edu	37	chr10	4889679	4889679	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atttgtttttctgtttttcaGaactaaaaatcacaaagact	4	6	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:4889679G>A	uc001ihi.2	+	10	1036	c.921_splice	c.e10-1	p.I307_splice	AKR1E2_uc001ihl.1_Intron|AKR1E2_uc009xhw.2_Splice_Site_p.I209_splice|AKR1E2_uc001ihj.2_Splice_Site|AKR1E2_uc001ihk.2_Splice_Site_p.I250_splice	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2							cytoplasm	1,5-anhydro-D-fructose reductase activity				0						CTGTTTTTCAGAACTAAAAAT	0.343													0	0	0	0.024245	0	14	106										A	4889679	G	A	4889679	5	1	88	1	0	0	0	0	0	0	1	0	474	956	33	1	958	1	AKR1E2	10	4889679	Splice_Site	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		4889679	130645068	195	26393										
PFKFB3	5209	broad.mit.edu	37	chr10	6262698	6262698	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcaggaccacatccagagccGcatcgtgtactacctgatga	10	13	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:6262698G>T	uc001ije.2	+	8	1085	c.701G>T	c.(700-702)CGC>CTC	p.R234L	PFKFB3_uc001ijd.2_Missense_Mutation_p.R214L|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Missense_Mutation_p.R248L|PFKFB3_uc001ijf.2_Missense_Mutation_p.R234L	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	234	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						ATCCAGAGCCGCATCGTGTAC	0.622													1	0	2.35188e-11	0.006122	2.49175e-11	16	115										T	6262698	G	T	6262698	3	4	88	1	0	0	0	0	1	0	0	0	11762	1087	38	4	751	4	PFKFB3	10	6262698	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1373019	6262698	129272049	196	26394										
FAM171A1	221061	broad.mit.edu	37	chr10	15325988	15325988	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaacttgataaaggcgacgcCatcagtccccgaggtgccag	12	12	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:15325988C>T	uc001iob.2	-	2	221	c.214G>A	c.(214-216)GGC>AGC	p.G72S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	72	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						AAGGCGACGCCATCAGTCCCC	0.577													0	0	0	0.027356	0	29	21										T	15325988	C	T	15325988	3	4	88	1	0	0	0	0	1	0	0	0	5490	594	21	2	2486	2	FAM171A1	10	15325988	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	9063290	15325988	120208759	197	26395										
ZNF33B	7582	broad.mit.edu	37	chr10	43088814	43088815	+	Missense_Mutation	DNP	AT	AT	TA													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagaaggttttcccacattcAtaacattcataaggtttcaa					rs149558146	by1000genomes	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:43088814_43088815AT>TA	uc001jaf.1	-	5	1698_1699	c.1583_1584AT>TA	c.(1582-1584)TAT>TTA	p.Y528L	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.Y416L|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	528	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCCCACATTCATAACATTCATA	0.411													0	0	0	0.004672	0	49	104										TA	43088815	AT	TA	43088814	3	4	88	1	0	0	0	0	1	0	0	0	17852	224	8	5	756	5	ZNF33B	10	43088814	Missense_Mutation	DNP	AT	TCGA-FJ-A3Z7-01A-12D-A23M-08	27762826	43088814	92445933	198	26396										
PPA1	5464	broad.mit.edu	37	chr10	71978536	71978536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttacctccatttttgcattaGaccagcgtggtacttcaact	6	11	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:71978536G>C	uc001jqv.1	-	3	268	c.161C>G	c.(160-162)TCT>TGT	p.S54C		NM_021129	NP_066952	Q15181	IPYR_HUMAN	pyrophosphatase 1	54					diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(1)	1						TTTTGCATTAGACCAGCGTGG	0.403													0	0	0	0.016723	0	12	16										C	71978536	G	C	71978536	3	2	88	1	0	0	0	0	1	0	0	0	12286	942	33	1	744	1	PPA1	10	71978536	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	28889722	71978536	63556211	199	26397										
OIT3	170392	broad.mit.edu	37	chr10	74692170	74692170	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gttggacgagcgttcccgctGtgcccagggttgccaccggc	15	14	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:74692170G>T	uc001jte.1	+	9	1744	c.1526G>T	c.(1525-1527)TGT>TTT	p.C509F	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	509	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					CGTTCCCGCTGTGCCCAGGGT	0.567													1	0	3.38236e-24	0.027894	3.73145e-24	38	93										T	74692170	G	T	74692170	3	4	88	1	0	0	0	0	1	0	0	0	10849	1377	48	4	1560	4	OIT3	10	74692170	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2713634	74692170	60842577	200	26398										
ZMIZ1	57178	broad.mit.edu	37	chr10	81050724	81050724	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctctgcccacaggtccttggGaaccctatggccaatgccaa	9	15	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:81050724G>A	uc001kaf.2	+	10	1121	c.549G>A	c.(547-549)GGG>GGA	p.G183G	ZMIZ1_uc001kag.2_Silent_p.G59G|ZMIZ1_uc001kah.1_Silent_p.G59G	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	183					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGGTCCTTGGGAACCCTATGG	0.567													0	0	0	0.020292	0	15	39										A	81050724	G	A	81050724	2	1	88	1	0	0	0	0	0	0	0	1	17693	1161	41	1		1	ZMIZ1	10	81050724	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6358554	81050724	54484023	201	26399										
RNLS	55328	broad.mit.edu	37	chr10	90342026	90342026	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acccaagtcagctgtgcactGaggattatgaggactgcagg	13	9	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:90342026G>T	uc001kfe.2	-	2	292	c.157C>A	c.(157-159)CAG>AAG	p.Q53K	RNLS_uc010qms.1_Intron|RNLS_uc001kfd.2_Missense_Mutation_p.Q53K	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	renalase isoform 1	53						extracellular region	oxidoreductase activity			ovary(1)	1						GCTGTGCACTGAGGATTATGA	0.433													1	0	2.80697e-09	0.010729	2.94794e-09	11	18										T	90342026	G	T	90342026	3	4	88	1	0	0	0	0	1	0	0	0	13505	1299	45	3	971	3	RNLS	10	90342026	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	9291302	90342026	45192721	202	26400										
NPM3	10360	broad.mit.edu	37	chr10	103542092	103542092	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttacaggtggttggagctggAagtcatccagactgagctgg	15	7	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:103542092A>C	uc001ktt.2	-	4	364	c.341T>G	c.(340-342)TTC>TGC	p.F114C		NM_006993	NP_008924	O75607	NPM3_HUMAN	nucleophosmin/nucleoplasmin 3	114							nucleic acid binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		TTGGAGCTGGAAGTCATCCAG	0.592													0	0	0	0.004672	0	3	10										C	103542092	A	C	103542092	3	2	88	1	0	0	0	0	1	0	0	0	10589	246	9	5	203	5	NPM3	10	103542092	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	13200066	103542092	31992655	203	26401										
C10orf79	80217	broad.mit.edu	37	chr10	105942272	105942272	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctaggtgtcctccaaatcgcCtatattaataaaaaagaaaa	5	8	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:105942272C>T	uc001kxw.2	-	17	2258	c.2142_splice	c.e17-1	p.K714_splice	C10orf79_uc009xxq.2_Splice_Site_p.K22_splice|C10orf79_uc001kxx.3_Splice_Site_p.K715_splice	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217												0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCCAAATCGCCTATATTAATA	0.323													0	0	0	0.008291	0	10	37										T	105942272	C	T	105942272	5	4	88	1	0	0	0	0	0	0	1	0	1618	695	24	2	2944	2	C10orf79	10	105942272	Splice_Site	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2400180	105942272	29592475	204	26402										
RAB11FIP2	22841	broad.mit.edu	37	chr10	119799755	119799755	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gataaatcagacattgaatgCgctgacgagagtcgctgagg	13	7	1	5	rs138355819		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:119799755C>A	uc001ldj.1	-	2	1115	c.675G>T	c.(673-675)GCG>GCT	p.A225A	RAB11FIP2_uc009xyz.1_Silent_p.A225A	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	225					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		ACATTGAATGCGCTGACGAGA	0.443													1	0	4.34086e-07	0.023175	4.50962e-07	36	134										A	119799755	C	A	119799755	2	1	88	1	0	0	0	0	0	0	0	1	12894	755	27	4		4	RAB11FIP2	10	119799755	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	13857483	119799755	15734992	205	26403										
DMBT1	1755	broad.mit.edu	37	chr10	124339407	124339407	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catagtgaagacgctggtgtCatctgctcaggtgggccttc	13	10	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:124339407C>T	uc001lgk.1	+	10	1099	c.993C>T	c.(991-993)GTC>GTT	p.V331V	DMBT1_uc001lgl.1_Silent_p.V331V|DMBT1_uc001lgm.1_Silent_p.V331V|DMBT1_uc009xzz.1_Silent_p.V331V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.V183V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	331	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ACGCTGGTGTCATCTGCTCAG	0.527													0	0	0	0.020292	0	14	60										T	124339407	C	T	124339407	2	4	88	1	0	0	0	0	0	0	0	1	4577	813	29	1		1	DMBT1	10	124339407	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4539652	124339407	11195340	206	26404										
C10orf137	26098	broad.mit.edu	37	chr10	127414265	127414265	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggccagtatcaatggtgatgGagccgctcagcctgtctcat	12	11	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr10:127414265G>T	uc001liq.1	+	6	943	c.650G>T	c.(649-651)GGA>GTA	p.G217V	C10orf137_uc001lin.2_Missense_Mutation_p.G217V|C10orf137_uc001lio.1_Missense_Mutation_p.G217V|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AATGGTGATGGAGCCGCTCAG	0.453													1	0	9.31168e-06	0.016723	9.61141e-06	12	38										T	127414265	G	T	127414265	3	4	88	1	0	0	0	0	1	0	0	0	1594	1174	41	3	672	3	C10orf137	10	127414265	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3074858	127414265	8120482	207	26405										
ANO9	338440	broad.mit.edu	37	chr11	433382	433382	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcaggcccctcaggctccagGaggaaagtgcggtacaggcc	15	13	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:433382G>A	uc001lpi.2	-	4	367	c.282C>T	c.(280-282)CTC>CTT	p.L94L	ANO9_uc010qvv.1_5'UTR	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	94	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CAGGCTCCAGGAGGAAAGTGC	0.647													0	0	0	0.007413	0	19	75										A	433382	G	A	433382	2	1	88	1	0	0	0	0	0	0	0	1	704	1161	41	1		1	ANO9	11	433382	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		433382	134573134	208	26406										
CTSD	1509	broad.mit.edu	37	chr11	1782618	1782618	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gggagtactttgagacggggCctttggcaatcaggtcctcc	14	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:1782618C>T	uc001luc.1	-	2	282	c.149G>A	c.(148-150)GGC>GAC	p.G50D	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	50					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAGACGGGGCCTTTGGCAAT	0.622													0	0	0	0.024245	0	15	43										T	1782618	C	T	1782618	3	4	88	1	0	0	0	0	1	0	0	0	4032	739	26	2	1121	2	CTSD	11	1782618	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1349236	1782618	133223898	209	26407										
OSBPL5	114879	broad.mit.edu	37	chr11	3111839	3111839	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgagagctctgggcaggactCaggcgtggatccgctgctct	15	11	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:3111839C>G	uc001lxk.2	-	20	2505	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q	OSBPL5_uc010qxq.1_Missense_Mutation_p.E694Q|OSBPL5_uc009ydw.2_Missense_Mutation_p.E715Q|OSBPL5_uc001lxl.2_Missense_Mutation_p.E715Q|OSBPL5_uc001lxj.2_Missense_Mutation_p.E237Q	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	783					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGGCAGGACTCAGGCGTGGAT	0.667													0	0	0	0.009096	0	4	34										G	3111839	C	G	3111839	3	3	88	1	0	0	0	0	1	0	0	0	11280	835	29	1	304	1	OSBPL5	11	3111839	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1329221	3111839	131894677	210	26408										
RRM1	6240	broad.mit.edu	37	chr11	4127384	4127384	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccttgactactaagcaccctGactatgctatcctggcagcc	7	15	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:4127384G>C	uc001lyw.3	+	3	536	c.217G>C	c.(217-219)GAC>CAC	p.D73H	RRM1_uc009yeh.1_Intron|RRM1_uc009yei.2_Missense_Mutation_p.D33H|RRM1_uc010qyc.1_Intron	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	73	ATP-cone.				deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	TAAGCACCCTGACTATGCTAT	0.448													0	0	0	0.008871	0	18	41										C	4127384	G	C	4127384	3	2	88	1	0	0	0	0	1	0	0	0	13681	1290	45	1	227	1	RRM1	11	4127384	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1015545	4127384	130879132	211	26409										
DNHD1	144132	broad.mit.edu	37	chr11	6588563	6588563	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtgcattgggcgctttggctCtgctgcaagcaacagggaaa	14	9	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:6588563C>G	uc001mdw.3	+	36	12388	c.11824C>G	c.(11824-11826)CTG>GTG	p.L3942V	DNHD1_uc001mea.3_Missense_Mutation_p.L211V|DNHD1_uc001meb.2_Missense_Mutation_p.L210V|DNHD1_uc001mec.2_Missense_Mutation_p.L210V|DNHD1_uc010rao.1_Missense_Mutation_p.L200V|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3942					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CGCTTTGGCTCTGCTGCAAGC	0.597													0	0	0	0.00499	0	17	47										G	6588563	C	G	6588563	3	3	88	1	0	0	0	0	1	0	0	0	4668	912	32	1	11967	1	DNHD1	11	6588563	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2461179	6588563	128417953	212	26410										
ABCC8	6833	broad.mit.edu	37	chr11	17464306	17464306	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggcaaaggccctgaggctggTcatctccttcctgcgggtcg	14	13	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:17464306T>A	uc001mnc.2	-	10	1717	c.1591A>T	c.(1591-1593)ACC>TCC	p.T531S	ABCC8_uc010rcy.1_Missense_Mutation_p.T530S	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	531	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CTGAGGCTGGTCATCTCCTTC	0.607													0	0	0	0.013537	0	13	65										A	17464306	T	A	17464306	3	1	88	1	0	0	0	0	1	0	0	0	58	1667	58	5	3274	5	ABCC8	11	17464306	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	10875743	17464306	117542210	213	26411										
KIF18A	81930	broad.mit.edu	37	chr11	28057955	28057955	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcactgtttatgtttgagctGatagcctgaaaacttgtagt	9	6	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:28057955G>A	uc001msc.2	-	14	2387	c.2205C>T	c.(2203-2205)ATC>ATT	p.I735I		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	735					blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TGTTTGAGCTGATAGCCTGAA	0.353													0	0	0	0.01441	0	56	153										A	28057955	G	A	28057955	2	1	88	1	0	0	0	0	0	0	0	1	8280	1280	45	1		1	KIF18A	11	28057955	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	10593649	28057955	106948561	214	26412										
EXT2	2132	broad.mit.edu	37	chr11	44129413	44129413	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agttttggccccattctatcGagtcctcaaatgactggaat	8	10	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:44129413G>T	uc001mxz.2	+	2	485	c.151G>T	c.(151-153)GAG>TAG	p.E51*	EXT2_uc010rfo.1_Nonsense_Mutation_p.E79*|EXT2_uc001mxy.2_Nonsense_Mutation_p.E64*|EXT2_uc009ykt.2_Nonsense_Mutation_p.E51*|EXT2_uc001mya.2_Nonsense_Mutation_p.E84*	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	51	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						CCATTCTATCGAGTCCTCAAA	0.532			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				1	0	3.07112e-06	0.010729	3.17679e-06	12	207										T	44129413	G	T	44129413	4	4	88	1	0	0	0	0	0	1	0	0	5324	1059	37	3	256	3	EXT2	11	44129413	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	16071458	44129413	90877103	215	26413										
MAPK8IP1	9479	broad.mit.edu	37	chr11	45924345	45924345	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcgactgcctgtcgtccccaGagcgggctgagcccccaggc	13	17	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:45924345G>C	uc001nbr.2	+	5	1197	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	343					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		GTCGTCCCCAGAGCGGGCTGA	0.721													0	0	0	0.009096	0	4	12										C	45924345	G	C	45924345	3	2	88	1	0	0	0	0	1	0	0	0	9284	943	33	1	1045	1	MAPK8IP1	11	45924345	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1794932	45924345	89082171	216	26414										
ACP2	53	broad.mit.edu	37	chr11	47267305	47267305	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttcgggttgaagcgctgcatCccgttgggagggaagagtcc	16	9	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:47267305C>T	uc001nei.2	-	4	495	c.378G>A	c.(376-378)GGG>GGA	p.G126G	ACP2_uc010rhe.1_Silent_p.G98G|ACP2_uc009ylj.2_Silent_p.G54G|ACP2_uc010rhf.1_Silent_p.G94G|ACP2_uc010rhg.1_Silent_p.G126G|ACP2_uc010rhh.1_5'UTR|ACP2_uc010rhi.1_5'UTR|ACP2_uc009ylk.2_Silent_p.G126G|ACP2_uc010rhj.1_Silent_p.G126G|NR1H3_uc009yll.1_5'Flank|NR1H3_uc010rhk.1_5'Flank	NM_001610	NP_001601	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal isoform 1	126	Lumenal (Potential).					integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			ovary(1)	1						AGCGCTGCATCCCGTTGGGAG	0.572													0	0	0	0.007413	0	16	127										T	47267305	C	T	47267305	2	4	88	1	0	0	0	0	0	0	0	1	163	842	30	1		1	ACP2	11	47267305	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1342960	47267305	87739211	217	26415										
OR4A5	81318	broad.mit.edu	37	chr11	51411989	51411989	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acagaaggaagcaaacctgtCgattcatgatggtcaaatag	10	7	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:51411989C>T	uc001nhi.1	-	1	407	c.407G>A	c.(406-408)CGA>CAA	p.R136Q		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GCAAACCTGTCGATTCATGAT	0.478													0	0	0	0.016723	0	13	89										T	51411989	C	T	51411989	3	4	88	1	0	0	0	0	1	0	0	0	11043	884	31	1	544	1	OR4A5	11	51411989	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4144684	51411989	83594527	218	26416										
OR8H3	390152	broad.mit.edu	37	chr11	55889867	55889867	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acatgatgggtagaaggaatGacacaaatgtggctgacttc	12	6	0	4	rs148197076		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:55889867G>A	uc001nii.1	+	1	19	c.19G>A	c.(19-21)GAC>AAC	p.D7N		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TAGAAGGAATGACACAAATGT	0.323													0	0	0	0.01441	0	45	187										A	55889867	G	A	55889867	3	1	88	1	0	0	0	0	1	0	0	0	11239	1290	45	1	21	1	OR8H3	11	55889867	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4477878	55889867	79116649	219	26417										
OR4D9	390199	broad.mit.edu	37	chr11	59283252	59283252	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatcctataatttacacgctGaggaatcaggaaatgaagtt	8	6	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:59283252G>T	uc010rkv.1	+	1	867	c.867G>T	c.(865-867)CTG>CTT	p.L289L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTACACGCTGAGGAATCAGG	0.453													1	0	6.32553e-13	0.024334	6.7463e-13	27	188										T	59283252	G	T	59283252	2	4	88	1	0	0	0	0	0	0	0	1	11059	1277	45	3		3	OR4D9	11	59283252	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3393385	59283252	75723264	220	26418										
OR4D9	390199	broad.mit.edu	37	chr11	59283288	59283288	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aagttggccatgaggaaactGaagagacggctaggacaatc	13	7	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:59283288G>A	uc010rkv.1	+	1	903	c.903G>A	c.(901-903)CTG>CTA	p.L301L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGAGGAAACTGAAGAGACGGC	0.388													0	0	0	0.010504	0	21	132										A	59283288	G	A	59283288	2	1	88	1	0	0	0	0	0	0	0	1	11059	1277	45	1		1	OR4D9	11	59283288	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	36	59283288	75723228	221	26419										
VPS37C	55048	broad.mit.edu	37	chr11	60901556	60901556	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctccacgagcttccggagctCctggtatctatccgagaggt	11	13	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:60901556C>G	uc001nqv.1	-	3	277	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	VPS37C_uc001nqw.1_Missense_Mutation_p.E73Q	NM_017966	NP_060436	A5D8V6	VP37C_HUMAN	vacuolar protein sorting 37C	73					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0						TTCCGGAGCTCCTGGTATCTA	0.617													0	0	0	0.013114	0	43	120										G	60901556	C	G	60901556	3	3	88	1	0	0	0	0	1	0	0	0	17204	864	30	1	862	1	VPS37C	11	60901556	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1618268	60901556	74104960	222	26420										
TRPT1	83707	broad.mit.edu	37	chr11	63991404	63991404	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cttggggctactctgacactCtgtctcttcatcaccagcca	7	15	5	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:63991404C>G	uc001nyo.2	-	8	920	c.706G>C	c.(706-708)GAG>CAG	p.E236Q	TRPT1_uc010rnc.1_Missense_Mutation_p.E237Q|TRPT1_uc010rnd.1_Missense_Mutation_p.E238Q|TRPT1_uc001nyn.2_Missense_Mutation_p.E187Q|TRPT1_uc010rne.1_Missense_Mutation_p.E199Q|TRPT1_uc010rnf.1_Missense_Mutation_p.E236Q|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_001033678	NP_001028850	Q86TN4	TRPT1_HUMAN	tRNA phosphotransferase 1 isoform 1	236							tRNA 2'-phosphotransferase activity				0						CTCTGACACTCTGTCTCTTCA	0.398													0	0	0	0.016723	0	13	116										G	63991404	C	G	63991404	3	3	88	1	0	0	0	0	1	0	0	0	16591	922	32	1	59	1	TRPT1	11	63991404	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3089848	63991404	71015112	223	26421										
FKBP2	2286	broad.mit.edu	37	chr11	64010754	64010754	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcccttggcacaggccaggtCatcaagggctgggaccaggg	15	12	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64010754C>T	uc001nyy.2	+	3	451	c.255C>T	c.(253-255)GTC>GTT	p.V85V	FKBP2_uc010rnh.1_Silent_p.V85V|FKBP2_uc001nyz.2_Silent_p.V85V	NM_004470	NP_004461	P26885	FKBP2_HUMAN	FK506 binding protein 2, 13kDa precursor	85	PPIase FKBP-type.				protein folding	endoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding				0						CAGGCCAGGTCATCAAGGGCT	0.622													0	0	0	0.004007	0	17	57										T	64010754	C	T	64010754	2	4	88	1	0	0	0	0	0	0	0	1	5908	813	29	1		1	FKBP2	11	64010754	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	19350	64010754	70995762	224	26422										
PLCB3	5331	broad.mit.edu	37	chr11	64033975	64033975	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gctcccgtgcagggaactgaCggagattaaccgtcggcaca	13	12	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64033975C>G	uc001nzb.2	+	29	3365	c.3365C>G	c.(3364-3366)ACG>AGG	p.T1122R	PLCB3_uc009ypg.1_Missense_Mutation_p.T1122R|PLCB3_uc009yph.1_Missense_Mutation_p.T1055R|PLCB3_uc009ypi.2_Missense_Mutation_p.T1122R	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1122					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						AGGGAACTGACGGAGATTAAC	0.652													0	0	0	0.008291	0	9	66										G	64033975	C	G	64033975	3	3	88	1	0	0	0	0	1	0	0	0	12029	536	19	4	3479	4	PLCB3	11	64033975	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	23221	64033975	70972541	225	26423										
SLC22A12	116085	broad.mit.edu	37	chr11	64360326	64360326	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggctgggattctggtgggaGctgctgcgtgcggccctgcc	18	11	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64360326G>A	uc001oam.1	+	2	1225	c.478G>A	c.(478-480)GCT>ACT	p.A160T	SLC22A12_uc009ypr.1_Missense_Mutation_p.A160T|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.A160T|SLC22A12_uc001oan.1_Missense_Mutation_p.A160T|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	160	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						TCTGGTGGGAGCTGCTGCGTG	0.632													0	0	0	0.014323	0	21	105										A	64360326	G	A	64360326	3	1	88	1	0	0	0	0	1	0	0	0	14443	971	34	2	484	2	SLC22A12	11	64360326	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	326351	64360326	70646190	226	26424										
ATG2A	23130	broad.mit.edu	37	chr11	64665359	64665359	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gggaggggctgtgtccacctCctggggcctcctgcgaacca	15	14	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64665359C>T	uc001obx.2	-	35	5061	c.4946G>A	c.(4945-4947)GGA>GAA	p.G1649E	ATG2A_uc001obw.2_Missense_Mutation_p.G414E	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1649							protein binding			ovary(1)|central_nervous_system(1)	2						GTGTCCACCTCCTGGGGCCTC	0.697													0	0	0	0.004482	0	7	49										T	64665359	C	T	64665359	3	4	88	1	0	0	0	0	1	0	0	0	1093	855	30	1	898	1	ATG2A	11	64665359	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	305033	64665359	70341157	227	26425										
PPP2R5B	5526	broad.mit.edu	37	chr11	64699064	64699064	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgctcaaatactggccaaaaAcctgcacccagaaggaggta	9	11	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:64699064A>G	uc001oby.2	+	10	1564	c.979A>G	c.(979-981)ACC>GCC	p.T327A	PPP2R5B_uc001obz.2_Missense_Mutation_p.T327A	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	327					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CTGGCCAAAAACCTGCACCCA	0.587													0	0	0	0.004672	0	3	16										G	64699064	A	G	64699064	3	3	88	1	0	0	0	0	1	0	0	0	12393	43	2	5	1013	5	PPP2R5B	11	64699064	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	33705	64699064	70307452	228	26426										
PPFIA1	8500	broad.mit.edu	37	chr11	70201868	70201868	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	attggccgcttgtttggcaaGaaagaaaagggccgacctgg	14	8	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:70201868G>A	uc001opo.2	+	18	2637	c.2439G>A	c.(2437-2439)AAG>AAA	p.K813K	PPFIA1_uc001opn.1_Silent_p.K813K|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	813					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGTTTGGCAAGAAAGAAAAGG	0.547													0	0	0	0.007291	0	27	62										A	70201868	G	A	70201868	2	1	88	1	0	0	0	0	0	0	0	1	12309	933	33	1		1	PPFIA1	11	70201868	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5502804	70201868	64804648	229	26427										
RNF121	55298	broad.mit.edu	37	chr11	71668300	71668300	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgtcagatctctctccagaaGagcaatggaggtaagtgtgg	13	7	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:71668300G>C	uc001ora.2	+	2	431	c.91G>C	c.(91-93)GAG>CAG	p.E31Q	RNF121_uc001ord.2_Intron|RNF121_uc001orb.2_Intron|RNF121_uc009yst.2_Intron	NM_018320	NP_060790	Q9H920	RN121_HUMAN	ring finger protein 121	31						integral to membrane	zinc ion binding				0						CTCTCCAGAAGAGCAATGGAG	0.443													0	0	0	0.024334	0	21	103										C	71668300	G	C	71668300	3	2	88	1	0	0	0	0	1	0	0	0	13431	943	33	1	97	1	RNF121	11	71668300	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1466432	71668300	63338216	230	26428										
KDM4D	55693	broad.mit.edu	37	chr11	94731431	94731431	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccatcaattttgccactccgCgatggattgattatggcaaa	8	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:94731431C>T	uc001pfe.2	+	3	1727	c.895C>T	c.(895-897)CGA>TGA	p.R299*		NM_018039	NP_060509	Q6B0I6	KDM4D_HUMAN	jumonji domain containing 2D	299	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGCCACTCCGCGATGGATTGA	0.537													0	0	0	0.007413	0	19	81										T	94731431	C	T	94731431	4	4	88	1	0	0	0	0	0	1	0	0	8131	760	27	2	897	2	KDM4D	11	94731431	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	23063131	94731431	40275085	231	26429										
MMP10	4319	broad.mit.edu	37	chr11	102645984	102645984	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catccaaatatgatggaagaGagggccaaaatgcagaaatc	10	7	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:102645984G>C	uc001phg.1	-	7	1023	c.1001C>G	c.(1000-1002)TCT>TGT	p.S334C		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	334	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		TGATGGAAGAGAGGGCCAAAA	0.353													0	0	0	0.004007	0	15	74										C	102645984	G	C	102645984	3	2	88	1	0	0	0	0	1	0	0	0	9649	942	33	1	445	1	MMP10	11	102645984	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7914553	102645984	32360532	232	26430										
ARHGAP20	57569	broad.mit.edu	37	chr11	110582896	110582896	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gccgagacactcctgtcaggGaagaggagcgccccggctgt	15	13	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:110582896G>C	uc001pkz.1	-	2	344	c.59C>G	c.(58-60)TCC>TGC	p.S20C	ARHGAP20_uc001pky.1_5'Flank|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	20					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCTGTCAGGGAAGAGGAGCG	0.483													0	0	0	0.001984	0	6	6										C	110582896	G	C	110582896	3	2	88	1	0	0	0	0	1	0	0	0	870	1174	41	1	3576	1	ARHGAP20	11	110582896	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7936912	110582896	24423620	233	26431										
TTC36	143941	broad.mit.edu	37	chr11	118399370	118399370	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tccaaggccctggagctgcaGggggtgatggcagcagaggc	18	10	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:118399370G>C	uc001ptg.1	+	2	171	c.171G>C	c.(169-171)CAG>CAC	p.Q57H	TTC36_uc010ryb.1_RNA|TTC36_uc010ryc.1_5'UTR|TMEM25_uc010ryd.1_5'Flank|TMEM25_uc001ptk.3_5'Flank|TMEM25_uc010rye.1_5'Flank|TMEM25_uc001pth.2_5'Flank|TMEM25_uc009zad.2_5'Flank|TMEM25_uc001pti.2_5'Flank|TMEM25_uc010ryf.1_5'Flank|TMEM25_uc001ptl.2_5'Flank|TMEM25_uc001ptm.2_5'Flank	NM_001080441	NP_001073910	A6NLP5	TTC36_HUMAN	tetratricopeptide repeat domain 36	57	TPR 1.						binding				0						TGGAGCTGCAGGGGGTGATGG	0.607													0	0	0	0.020292	0	14	77										C	118399370	G	C	118399370	3	2	88	1	0	0	0	0	1	0	0	0	16701	991	35	4	177	4	TTC36	11	118399370	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7816474	118399370	16607146	234	26432										
OR8D1	283159	broad.mit.edu	37	chr11	124180599	124180599	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaagaggggcagctggagctCtgcttgctgtgttaaaccat	14	8	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:124180599C>T	uc010sag.1	-	1	64	c.64G>A	c.(64-66)GAG>AAG	p.E22K		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AGCTGGAGCTCTGCTTGCTGT	0.453													0	0	0	0.01441	0	61	132										T	124180599	C	T	124180599	3	4	88	1	0	0	0	0	1	0	0	0	11231	922	32	1	865	1	OR8D1	11	124180599	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5781229	124180599	10825917	235	26433										
HYLS1	219844	broad.mit.edu	37	chr11	125769668	125769668	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgggacttaagacaaaggctGatgaatgtacagttccagga	12	6	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:125769668G>A	uc009zbv.2	+	4	939	c.405G>A	c.(403-405)CTG>CTA	p.L135L	HYLS1_uc001qcx.3_Silent_p.L135L|PUS3_uc001qcy.2_Intron	NM_145014	NP_659451	Q96M11	HYLS1_HUMAN	hydrolethalus syndrome 1	135						centrosome|nucleus				upper_aerodigestive_tract(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		GACAAAGGCTGATGAATGTAC	0.383													0	0	0	0.01441	0	52	118										A	125769668	G	A	125769668	2	1	88	1	0	0	0	0	0	0	0	1	7469	1277	45	1		1	HYLS1	11	125769668	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1589069	125769668	9236848	236	26434										
NTM	50863	broad.mit.edu	37	chr11	132016342	132016342	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggatgtgtatgacgagggcCcttacacctgctcggtgcag	14	10	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr11:132016342C>A	uc001qgp.2	+	2	998	c.334C>A	c.(334-336)CCT>ACT	p.P112T	NTM_uc001qgm.2_Missense_Mutation_p.P112T|NTM_uc010sch.1_Missense_Mutation_p.P103T|NTM_uc010sci.1_Missense_Mutation_p.P112T|NTM_uc010scj.1_Missense_Mutation_p.P71T|NTM_uc001qgo.2_Missense_Mutation_p.P112T|NTM_uc001qgq.2_Missense_Mutation_p.P112T	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	112	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane		p.P112H(1)		ovary(4)|central_nervous_system(1)|skin(1)	6						TGACGAGGGCCCTTACACCTG	0.577													1	0	1.49906e-05	0.020292	1.544e-05	12	88										A	132016342	C	A	132016342	3	1	88	1	0	0	0	0	1	0	0	0	10699	623	22	4	426	4	NTM	11	132016342	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6246674	132016342	2990174	237	26435										
KLRB1	3820	broad.mit.edu	37	chr12	9752379	9752379	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttacctgttgttttattcctGctctgttgaatgtccacact	6	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:9752379G>T	uc010sgt.1	-	3	305	c.243C>A	c.(241-243)AGC>AGA	p.S81R		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B,	81	Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						TTTTATTCCTGCTCTGTTGAA	0.264													1	0	5.73435e-26	0.01441	6.34074e-26	42	127										T	9752379	G	T	9752379	3	4	88	1	0	0	0	0	1	0	0	0	8414	1310	46	4	449	4	KLRB1	12	9752379	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		9752379	124099516	238	26436										
WBP11	51729	broad.mit.edu	37	chr12	14949871	14949871	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaatacgttcaaaggtttcaCgcagctttttacgcttgtct	8	9	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:14949871C>T	uc001rci.2	-	5	418	c.257G>A	c.(256-258)CGT>CAT	p.R86H		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	86	Potential.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						AAAGGTTTCACGCAGCTTTTT	0.338													0	0	0	0.01892	0	24	98										T	14949871	C	T	14949871	3	4	88	1	0	0	0	0	1	0	0	0	17255	536	19	2	1700	2	WBP11	12	14949871	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5197492	14949871	118902024	239	26437										
RECQL	5965	broad.mit.edu	37	chr12	21624414	21624414	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aatcttctccagatcttcacGaggaagtgtgggagccacaa	10	10	4	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:21624414G>C	uc001rex.2	-	14	1963	c.1615C>G	c.(1615-1617)CGT>GGT	p.R539G	RECQL_uc001rey.2_Missense_Mutation_p.R539G	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	539					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						AGATCTTCACGAGGAAGTGTG	0.388								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.007291	0	26	133										C	21624414	G	C	21624414	3	2	88	1	0	0	0	0	1	0	0	0	13201	1058	37	1	346	1	RECQL	12	21624414	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6674543	21624414	112227481	240	26438										
ITPR2	3709	broad.mit.edu	37	chr12	26709193	26709193	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgaaagcgccacatcttattCttgcatcgcttccctcaggg	8	13	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:26709193C>A	uc001rhg.2	-	36	5354	c.4937G>T	c.(4936-4938)AGA>ATA	p.R1646I		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1646	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ACATCTTATTCTTGCATCGCT	0.458													1	0	1.14856e-27	0.01441	1.27295e-27	59	134										A	26709193	C	A	26709193	3	1	88	1	0	0	0	0	1	0	0	0	7921	913	32	3	3256	3	ITPR2	12	26709193	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5084779	26709193	107142702	241	26439										
ITPR2	3709	broad.mit.edu	37	chr12	26709224	26709224	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tccctcagggaacagcagttCtggactgtacaatacatcaa	8	11	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:26709224C>T	uc001rhg.2	-	36	5323	c.4906G>A	c.(4906-4908)GAA>AAA	p.E1636K		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1636	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AACAGCAGTTCTGGACTGTAC	0.473													0	0	0	0.01441	0	46	111										T	26709224	C	T	26709224	3	4	88	1	0	0	0	0	1	0	0	0	7921	922	32	1	3287	1	ITPR2	12	26709224	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	31	26709224	107142671	242	26440										
OVCH1	341350	broad.mit.edu	37	chr12	29598224	29598224	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aacatacctaggactttcaaGacaatatagcttataccaaa	4	9	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:29598224G>C	uc001rix.1	-	23	2868	c.2868C>G	c.(2866-2868)GTC>GTG	p.V956V		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	956	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GGACTTTCAAGACAATATAGC	0.353													0	0	0	0.007835	0	40	97										C	29598224	G	C	29598224	2	2	88	1	0	0	0	0	0	0	0	1	11323	929	33	1		1	OVCH1	12	29598224	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2889000	29598224	104253671	243	26441										
C12orf35	55196	broad.mit.edu	37	chr12	32133998	32133998	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accaaattaccacaacatctCagagttctttcagctatcct	3	13	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:32133998C>G	uc001rks.2	+	4	523	c.109C>G	c.(109-111)CAG>GAG	p.Q37E		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	37										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CACAACATCTCAGAGTTCTTT	0.393													0	0	0	0.012319	0	23	120										G	32133998	C	G	32133998	3	3	88	1	0	0	0	0	1	0	0	0	1682	827	29	1	111	1	C12orf35	12	32133998	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2535774	32133998	101717897	244	26442										
C12orf44	60673	broad.mit.edu	37	chr12	52470629	52470629	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atgtccttggagttctaccaGaagaagaagtctcgctggcc	11	10	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:52470629G>A	uc001rzu.3	+	4	787	c.312G>A	c.(310-312)CAG>CAA	p.Q104Q	C12orf44_uc009zmd.2_Silent_p.Q104Q|uc009zme.1_5'Flank	NM_021934	NP_068753	Q9BSB4	ATGA1_HUMAN	Atg13-interacting protein	104					autophagic vacuole assembly	pre-autophagosomal structure	identical protein binding|protein complex binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0978)		AGTTCTACCAGAAGAAGAAGT	0.592													0	0	0	0.00632	0	28	53										A	52470629	G	A	52470629	2	1	88	1	0	0	0	0	0	0	0	1	1690	933	33	1		1	C12orf44	12	52470629	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	20336631	52470629	81381266	245	26443										
KRT79	338785	broad.mit.edu	37	chr12	53216964	53216964	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcttcttctgagcatccttGagtgccagctccccacgctg	9	15	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:53216964G>C	uc001sbb.2	-	7	1236	c.1203C>G	c.(1201-1203)CTC>CTG	p.L401L	KRT79_uc001sba.2_Silent_p.L172L	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	401	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						GAGCATCCTTGAGTGCCAGCT	0.617													0	0	0	0.016522	0	24	43										C	53216964	G	C	53216964	2	2	88	1	0	0	0	0	0	0	0	1	8492	1277	45	1		1	KRT79	12	53216964	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	746335	53216964	80634931	246	26444										
MFSD5	84975	broad.mit.edu	37	chr12	53646663	53646663	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttttgtaggcctcctggcctCctgcctggggctggaactgt	13	12	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:53646663C>A	uc001sci.1	+	2	235	c.44C>A	c.(43-45)TCC>TAC	p.S15Y	MFSD5_uc001sch.1_Missense_Mutation_p.S122Y	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	15	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						CTCCTGGCCTCCTGCCTGGGG	0.592													1	0	8.16277e-20	0.027894	8.96414e-20	42	65										A	53646663	C	A	53646663	3	1	88	1	0	0	0	0	1	0	0	0	9534	855	30	3	371	3	MFSD5	12	53646663	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	429699	53646663	80205232	247	26445										
NCKAP1L	3071	broad.mit.edu	37	chr12	54902260	54902260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttctgtcacggattgaagatCggcggatactcattggcatg	12	8	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:54902260C>T	uc001sgc.3	+	5	530	c.451C>T	c.(451-453)CGG>TGG	p.R151W	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.R101W	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	151					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GATTGAAGATCGGCGGATACT	0.423													0	0	0	0.01441	0	136	259										T	54902260	C	T	54902260	3	4	88	1	0	0	0	0	1	0	0	0	10222	875	31	1	469	1	NCKAP1L	12	54902260	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1255597	54902260	78949635	248	26446										
SMARCC2	6601	broad.mit.edu	37	chr12	56559126	56559127	+	Frame_Shift_Ins	INS	-	-	G													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggtccaggggggggaaccccINStggtgggactgccccaggct							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:56559126_56559127insG	uc001skb.2	-	26	3220_3221	c.3114_3115insC	c.(3112-3117)CCAGGGfs	p.P1038fs	SMARCC2_uc001skd.2_Frame_Shift_Ins_p.P1069fs|SMARCC2_uc001ska.2_Frame_Shift_Ins_p.P1069fs|SMARCC2_uc001skc.2_Frame_Shift_Ins_p.P1068fs|SMARCC2_uc010sqf.1_Frame_Shift_Ins_p.P958fs	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	1038_1039	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GGGGGAACCCCTGGTGGGACTG	0.584																		8	168	---	---								G	56559127	-	G	56559126	7	5	88	1	0	1	1	0	0	0	0	0	14776	681	24	0	541	0	SMARCC2	12	56559126	Frame_Shift_Ins	INS	-	TCGA-FJ-A3Z7-01A-12D-A23M-08	1656866	56559126	77292769	249	26447										
PTPRB	5787	broad.mit.edu	37	chr12	70963557	70963557	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagtctgtggaacgtgtgctCaaagacgtgcttgggaatag	14	7	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:70963557C>G	uc001swb.3	-	12	2908	c.2878G>C	c.(2878-2880)GAG>CAG	p.E960Q	PTPRB_uc010sto.1_Missense_Mutation_p.E960Q|PTPRB_uc010stp.1_Missense_Mutation_p.E870Q|PTPRB_uc001swc.3_Missense_Mutation_p.E1178Q|PTPRB_uc001swa.3_Missense_Mutation_p.E1090Q|PTPRB_uc001swd.3_Missense_Mutation_p.E1177Q|PTPRB_uc009zrr.1_Missense_Mutation_p.E1057Q	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	960	Fibronectin type-III 11.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AACGTGTGCTCAAAGACGTGC	0.542													0	0	0	0.012319	0	19	58										G	70963557	C	G	70963557	3	3	88	1	0	0	0	0	1	0	0	0	12796	835	29	1	3199	1	PTPRB	12	70963557	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	14404431	70963557	62888338	250	26448										
PPP1R12A	4659	broad.mit.edu	37	chr12	80200075	80200075	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atgtggtgcttggaacactaGaactaatcaaatcatcttgt	8	7	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:80200075G>C	uc001syz.2	-	13	1961	c.1694C>G	c.(1693-1695)TCT>TGT	p.S565C	PPP1R12A_uc010suc.1_Missense_Mutation_p.S478C|PPP1R12A_uc001sza.2_Intron|PPP1R12A_uc010sud.1_Missense_Mutation_p.S565C|PPP1R12A_uc001szb.2_Missense_Mutation_p.S565C|PPP1R12A_uc001szc.2_Missense_Mutation_p.S565C	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	565	Ser/Thr-rich.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						TGGAACACTAGAACTAATCAA	0.388													0	0	0	0.01441	0	50	281										C	80200075	G	C	80200075	3	2	88	1	0	0	0	0	1	0	0	0	12354	942	33	1	1450	1	PPP1R12A	12	80200075	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	9236518	80200075	53651820	251	26449										
PPFIA2	8499	broad.mit.edu	37	chr12	81746948	81746948	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcctgaagcatcatggctagCgtctgggcatcggaatgacc	12	11	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:81746948C>G	uc001szo.1	-	17	2105	c.1944G>C	c.(1942-1944)ACG>ACC	p.T648T	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	574										ovary(3)|lung(2)|pancreas(1)	6						TCATGGCTAGCGTCTGGGCAT	0.383													0	0	0	0.019004	0	33	112										G	81746948	C	G	81746948	2	3	88	1	0	0	0	0	0	0	0	1	12310	755	27	4		4	PPFIA2	12	81746948	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1546873	81746948	52104947	252	26450										
IKBIP	121457	broad.mit.edu	37	chr12	99028127	99028127	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttgttggaattcattggtttCtagtttcagtaactggtatt	9	4	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:99028127C>G	uc001tfv.2	-	2	354	c.244G>C	c.(244-246)GAA>CAA	p.E82Q	IKBIP_uc001tfw.2_Intron|IKBIP_uc001tfx.2_Missense_Mutation_p.E82Q	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	82					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TCATTGGTTTCTAGTTTCAGT	0.328													0	0	0	0.004482	0	9	55										G	99028127	C	G	99028127	3	3	88	1	0	0	0	0	1	0	0	0	7609	922	32	1	1657	1	IKBIP	12	99028127	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	17281179	99028127	34823768	253	26451										
MMAB	326625	broad.mit.edu	37	chr12	110002954	110002954	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcttcggcaaatgtatggccCttttctgtgactaattccag	8	10	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:110002954C>T	uc001tou.2	-	4	391	c.318G>A	c.(316-318)AAG>AAA	p.K106K	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Silent_p.K15K|MMAB_uc001tox.2_Silent_p.K54K	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	106					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGTATGGCCCTTTTCTGTGA	0.463													0	0	0	0.027894	0	38	120										T	110002954	C	T	110002954	2	4	88	1	0	0	0	0	0	0	0	1	9640	680	24	2		2	MMAB	12	110002954	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10974827	110002954	23848941	254	26452										
TBX5	6910	broad.mit.edu	37	chr12	114793706	114793706	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cttggccacgtgttgcagctGatgtcctctaggctgggcac	13	12	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:114793706G>A	uc001tvo.2	-	9	1683	c.1188C>T	c.(1186-1188)ATC>ATT	p.I396I	TBX5_uc001tvp.2_Silent_p.I396I|TBX5_uc001tvq.2_Silent_p.I346I	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	396					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TGTTGCAGCTGATGTCCTCTA	0.632													0	0	0	0.00499	0	15	72										A	114793706	G	A	114793706	2	1	88	1	0	0	0	0	0	0	0	1	15658	1280	45	1		1	TBX5	12	114793706	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	4790752	114793706	19058189	255	26453										
C12orf49	79794	broad.mit.edu	37	chr12	117175649	117175649	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gacagcccgaagaccagggcGagcacccacctcttccgcag	11	17	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:117175649G>A	uc001tvz.1	-	1	195	c.57C>T	c.(55-57)CTC>CTT	p.L19L	RNFT2_uc009zwn.2_5'Flank|RNFT2_uc001twb.3_5'Flank|RNFT2_uc001twa.3_5'Flank|C12orf49_uc009zwm.1_Missense_Mutation_p.R42C	NM_024738	NP_079014	Q9H741	CL049_HUMAN	hypothetical protein LOC79794 precursor	19						extracellular region				ovary(1)	1	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		AGACCAGGGCGAGCACCCACC	0.542													0	0	0	0.004482	0	7	30										A	117175649	G	A	117175649	2	1	88	1	0	0	0	0	0	0	0	1	1693	1045	37	1		1	C12orf49	12	117175649	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2381943	117175649	16676246	256	26454										
SBNO1	55206	broad.mit.edu	37	chr12	123830066	123830066	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aattgtagatcccaagggtgGaagatgatttatttgattca	10	4	1	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:123830066G>T	uc010tap.1	-	3	289	c.289C>A	c.(289-291)CCA>ACA	p.P97T	SBNO1_uc010tao.1_Missense_Mutation_p.P96T|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.P97T|SBNO1_uc001ueu.2_Missense_Mutation_p.P96T|SBNO1_uc001uev.2_Missense_Mutation_p.P95T|SBNO1_uc009zxy.1_Missense_Mutation_p.P62T	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	97							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CCCAAGGGTGGAAGATGATTT	0.378													1	0	1.05317e-09	0.020292	1.10848e-09	14	69										T	123830066	G	T	123830066	3	4	88	1	0	0	0	0	1	0	0	0	13862	1174	41	3	4008	3	SBNO1	12	123830066	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6654417	123830066	10021829	257	26455										
CHFR	55743	broad.mit.edu	37	chr12	133420656	133420656	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttctgccgatactgataggtCagctcacggaagctgcgcag	12	11	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr12:133420656C>A	uc001ulf.2	-	16	1920	c.1836G>T	c.(1834-1836)CTG>CTT	p.L612L	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Silent_p.L600L|CHFR_uc010tbs.1_Silent_p.L611L|CHFR_uc001uld.2_Silent_p.L571L|CHFR_uc010tbt.1_Silent_p.L520L	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	612					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		ACTGATAGGTCAGCTCACGGA	0.542													1	0	1.80694e-10	0.009535	1.9102e-10	28	31										A	133420656	C	A	133420656	2	1	88	1	0	0	0	0	0	0	0	1	3337	813	29	3		3	CHFR	12	133420656	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	9590590	133420656	431239	258	26456										
FAM123A	219287	broad.mit.edu	37	chr13	25744470	25744470	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tagataggtgtcgtccacctCgtccgggctggccatctctt	11	13	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:25744470C>G	uc001uqb.2	-	1	1388	c.1288G>C	c.(1288-1290)GAG>CAG	p.E430Q	FAM123A_uc001uqa.2_Missense_Mutation_p.E311Q|FAM123A_uc001uqc.2_Missense_Mutation_p.E311Q	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	430										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCGTCCACCTCGTCCGGGCTG	0.652													0	0	0	0.006214	0	9	22										G	25744470	C	G	25744470	3	3	88	1	0	0	0	0	1	0	0	0	5422	893	31	1	731	1	FAM123A	13	25744470	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		25744470	89425408	259	26457										
WASF3	10810	broad.mit.edu	37	chr13	27216530	27216530	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gccgctatcatacgccagctGagcagtctgagtaagccatc	10	13	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:27216530G>A	uc001uqv.2	+	3	348	c.123G>A	c.(121-123)CTG>CTA	p.L41L	WASF3_uc001uqw.2_Silent_p.L41L	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	41					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TACGCCAGCTGAGCAGTCTGA	0.418													0	0	0	0.01441	0	69	140										A	27216530	G	A	27216530	2	1	88	1	0	0	0	0	0	0	0	1	17251	1277	45	1		1	WASF3	13	27216530	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1472060	27216530	87953348	260	26458										
FLT1	2321	broad.mit.edu	37	chr13	28880827	28880827	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	attcttactcaatcttgagcGaggccttgggtttgctgtca	10	9	4	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:28880827G>A	uc001usb.3	-	29	4088	c.3803C>T	c.(3802-3804)TCG>TTG	p.S1268L	FLT1_uc010aap.2_Missense_Mutation_p.S273L|FLT1_uc010aaq.2_Missense_Mutation_p.S393L|FLT1_uc001usa.3_Missense_Mutation_p.S486L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1268	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	AATCTTGAGCGAGGCCTTGGG	0.532													0	0	0	0.012319	0	22	45										A	28880827	G	A	28880827	3	1	88	1	0	0	0	0	1	0	0	0	5941	1059	37	1	221	1	FLT1	13	28880827	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1664297	28880827	86289051	261	26459										
DCLK1	9201	broad.mit.edu	37	chr13	36445432	36445432	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggtggtgctcctgcgggatGatgaagctattttggtgtaa	15	5	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:36445432G>A	uc001uvf.2	-	5	1102	c.869C>T	c.(868-870)TCA>TTA	p.S290L	uc001uvi.1_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	290	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CCTGCGGGATGATGAAGCTAT	0.507													0	0	0	0.01441	0	75	106										A	36445432	G	A	36445432	3	1	88	1	0	0	0	0	1	0	0	0	4291	1294	45	1	1376	1	DCLK1	13	36445432	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7564605	36445432	78724446	262	26460										
ENOX1	55068	broad.mit.edu	37	chr13	43872592	43872592	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttgtttcagcagctccacctCattcctgtaggcatccagct	7	14	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:43872592C>T	uc001uza.3	-	12	1636	c.1336G>A	c.(1336-1338)GAG>AAG	p.E446K	ENOX1_uc001uzb.3_Missense_Mutation_p.E446K|ENOX1_uc001uzc.3_Missense_Mutation_p.E446K|ENOX1_uc001uyz.3_Missense_Mutation_p.E55K	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	446	Potential.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		AGCTCCACCTCATTCCTGTAG	0.522													0	0	0	0.016723	0	13	151										T	43872592	C	T	43872592	3	4	88	1	0	0	0	0	1	0	0	0	5126	835	29	1	619	1	ENOX1	13	43872592	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	7427160	43872592	71297286	263	26461										
ZC3H13	23091	broad.mit.edu	37	chr13	46543642	46543642	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttcatcagaaatatcagaatCacctttggattttttacgtt	5	7	4	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:46543642C>T	uc010tfw.1	-	13	3043	c.3037G>A	c.(3037-3039)GAT>AAT	p.D1013N	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.D1013N|ZC3H13_uc001vat.1_Missense_Mutation_p.D1013N	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1013	Lys-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		ATATCAGAATCACCTTTGGAT	0.373													0	0	0	0.008291	0	10	64										T	46543642	C	T	46543642	3	4	88	1	0	0	0	0	1	0	0	0	17562	826	29	1	1673	1	ZC3H13	13	46543642	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2671050	46543642	68626236	264	26462										
UCHL3	7347	broad.mit.edu	37	chr13	76124114	76124114	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tctctgtttcgttttcaggtCaccaaccaggtgagtgaggt	11	9	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:76124114C>T	uc001vjq.2	+	2	75	c.45C>T	c.(43-45)GTC>GTT	p.V15V		NM_006002	NP_005993	P15374	UCHL3_HUMAN	ubiquitin carboxyl-terminal esterase L3	15					ubiquitin-dependent protein catabolic process	cytoplasm	cysteine-type peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity				0				GBM - Glioblastoma multiforme(99;0.0125)		GTTTTCAGGTCACCAACCAGG	0.622											OREG0022446	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	84	119										T	76124114	C	T	76124114	2	4	88	1	0	0	0	0	0	0	0	1	16918	813	29	1		1	UCHL3	13	76124114	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	29580472	76124114	39045764	265	26463										
SLITRK1	114798	broad.mit.edu	37	chr13	84453946	84453946	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agaggagcatgaaatcctttCtaaagaagttcaccggcgtc	10	9	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:84453946C>T	uc001vlk.2	-	1	2583	c.1697G>A	c.(1696-1698)AGA>AAA	p.R566K		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	566	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAAATCCTTTCTAAAGAAGTT	0.517													0	0	0	0.004482	0	8	41										T	84453946	C	T	84453946	3	4	88	1	0	0	0	0	1	0	0	0	14742	913	32	1	397	1	SLITRK1	13	84453946	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	8329832	84453946	30715932	266	26464										
MYO16	23026	broad.mit.edu	37	chr13	109777464	109777464	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gatccttctataaaagttatCagaggatttttagcacgcca	7	8	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:109777464C>G	uc001vqt.1	+	30	3600	c.3474C>G	c.(3472-3474)ATC>ATG	p.I1158M	MYO16_uc010agk.1_Missense_Mutation_p.I1180M|MYO16_uc010tjh.1_Missense_Mutation_p.I670M	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1158	IQ.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TAAAAGTTATCAGAGGATTTT	0.383													0	0	0	0.007413	0	17	45										G	109777464	C	G	109777464	3	3	88	1	0	0	0	0	1	0	0	0	10064	816	29	1	3588	1	MYO16	13	109777464	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	25323518	109777464	5392414	267	26465										
MCF2L	23263	broad.mit.edu	37	chr13	113718683	113718683	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aagtcgcagctgaccgaggaCctgggtgggaccctggacta	15	11	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr13:113718683C>A	uc001vsu.2	+	6	748	c.726C>A	c.(724-726)GAC>GAA	p.D242E	MCF2L_uc001vsq.2_Missense_Mutation_p.D242E|MCF2L_uc010tjr.1_Missense_Mutation_p.D185E|MCF2L_uc001vsr.2_Missense_Mutation_p.D189E|MCF2L_uc001vss.3_Missense_Mutation_p.D183E|MCF2L_uc010tjs.1_Missense_Mutation_p.D183E|MCF2L_uc001vst.1_Missense_Mutation_p.D147E	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	215	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TGACCGAGGACCTGGGTGGGA	0.612													1	0	0.00621372	0.006214	0.00627899	9	73										A	113718683	C	A	113718683	3	1	88	1	0	0	0	0	1	0	0	0	9379	506	18	4	843	4	MCF2L	13	113718683	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3941219	113718683	1451195	268	26466										
CMTM5	116173	broad.mit.edu	37	chr14	23846484	23846484	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctcagtgctcgagatcgccgGgaccggcaccctgaggaggg	16	13	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:23846484G>A	uc010akm.2	+	1	468	c.24G>A	c.(22-24)CGG>CGA	p.R8R	CMTM5_uc001wjs.2_Silent_p.R8R|CMTM5_uc001wjt.2_Silent_p.R8R|CMTM5_uc010akn.2_Silent_p.R8R|CMTM5_uc001wju.2_Silent_p.R8R|CMTM5_uc010ako.2_RNA	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	8					chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GAGATCGCCGGGACCGGCACC	0.612													0	0	0	0.008291	0	9	54										A	23846484	G	A	23846484	2	1	88	1	0	0	0	0	0	0	0	1	3586	1219	43	2		2	CMTM5	14	23846484	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		23846484	83503056	269	26467										
IRF9	10379	broad.mit.edu	37	chr14	24635333	24635333	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccatctcttccaatacagatGgagcaggcctttgcccgata	8	13	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:24635333G>A	uc001wmq.2	+	9	1237	c.1110G>A	c.(1108-1110)ATG>ATA	p.M370I	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_Missense_Mutation_p.M154I	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	370					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		CAATACAGATGGAGCAGGCCT	0.592													0	0	0	0.020292	0	13	23										A	24635333	G	A	24635333	3	1	88	1	0	0	0	0	1	0	0	0	7837	1348	47	2	1140	2	IRF9	14	24635333	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	788849	24635333	82714207	270	26468										
NYNRIN	57523	broad.mit.edu	37	chr14	24878489	24878489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aggctggaggtgagccggggGatcaagggagtatgcagtta	19	5	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:24878489G>A	uc001wpf.3	+	4	1807	c.1489G>A	c.(1489-1491)GAT>AAT	p.D497N		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	497					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						TGAGCCGGGGGATCAAGGGAG	0.572													0	0	0	0.008291	0	9	37										A	24878489	G	A	24878489	3	1	88	1	0	0	0	0	1	0	0	0	10796	1174	41	1	1499	1	NYNRIN	14	24878489	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	243156	24878489	82471051	271	26469										
PCNX	22990	broad.mit.edu	37	chr14	71374675	71374675	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ttcgtgaacgcgctgcacctCtacctgtggctctttctgct	9	14	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:71374675C>G	uc001xmo.2	+	1	554	c.108C>G	c.(106-108)CTC>CTG	p.L36L	PCNX_uc001xmn.3_Silent_p.L36L|PCNX_uc010are.1_Silent_p.L36L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	36	Helical; (Potential).					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		CGCTGCACCTCTACCTGTGGC	0.687													0	0	0	0.004482	0	6	12										G	71374675	C	G	71374675	2	3	88	1	0	0	0	0	0	0	0	1	11591	900	32	1		1	PCNX	14	71374675	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	46496186	71374675	35974865	272	26470										
HEATR4	399671	broad.mit.edu	37	chr14	73967257	73967257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atgtttccctgactcaccatCttgtcgcggatctgcagggc	10	13	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:73967257C>G	uc010tub.1	-	12	2605	c.2283G>C	c.(2281-2283)AAG>AAC	p.K761N	HEATR4_uc010tua.1_Missense_Mutation_p.K714N	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		GACTCACCATCTTGTCGCGGA	0.532													0	0	0	0.013114	0	41	35										G	73967257	C	G	73967257	3	3	88	1	0	0	0	0	1	0	0	0	7030	912	32	1	825	1	HEATR4	14	73967257	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2592582	73967257	33382283	273	26471										
C14orf45	80127	broad.mit.edu	37	chr14	74523874	74523874	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agtaagcttcaagataaaatCttcatcacccagcaaattgc	5	10	4	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:74523874C>T	uc010tup.1	+	11	1614	c.1491C>T	c.(1489-1491)ATC>ATT	p.I497I	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	497											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		AAGATAAAATCTTCATCACCC	0.398													0	0	0	0.007291	0	22	77										T	74523874	C	T	74523874	2	4	88	1	0	0	0	0	0	0	0	1	1775	903	32	1		1	C14orf45	14	74523874	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	556617	74523874	32825666	274	26472										
DICER1	23405	broad.mit.edu	37	chr14	95569761	95569761	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agatatgtggtgatggcatgCtttaaaaaggagtcgccaag	13	5	0	2	rs45562437	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr14:95569761C>T	uc001ydw.2	-	22	4154	c.3972G>A	c.(3970-3972)AAG>AAA	p.K1324K	DICER1_uc010avh.1_Silent_p.K222K|DICER1_uc001ydv.2_Silent_p.K1314K|DICER1_uc001ydx.2_Silent_p.K1324K|DICER1_uc001ydy.1_Silent_p.K176K	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1324	RNase III 1.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGATGGCATGCTTTAAAAAGG	0.428			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.014758	0	4	63										T	95569761	C	T	95569761	2	4	88	1	0	0	0	0	0	0	0	1	4521	796	28	2		2	DICER1	14	95569761	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	21045887	95569761	11779779	275	26473										
UBE3A	7337	broad.mit.edu	37	chr15	25585264	25585264	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gggccatttttggctataatCatctttaattttcctagtcc	6	9	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:25585264C>T	uc001zaq.2	-	10	2475	c.2475G>A	c.(2473-2475)ATG>ATA	p.M825I	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.M802I|UBE3A_uc001zas.2_Missense_Mutation_p.M822I|UBE3A_uc001zat.2_Missense_Mutation_p.M802I	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	825	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TGGCTATAATCATCTTTAATT	0.393													0	0	0	0.014323	0	22	88										T	25585264	C	T	25585264	3	4	88	1	0	0	0	0	1	0	0	0	16876	826	29	1	160	1	UBE3A	15	25585264	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		25585264	76946128	276	26474										
HERC2	8924	broad.mit.edu	37	chr15	28511100	28511101	+	Frame_Shift_Ins	INS	-	-	C													0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tccagagaaggcggagatcaINSccttaggctcctccaaaggc							TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:28511100_28511101insC	uc001zbj.2	-	13	1724_1725	c.1618_1619insG	c.(1618-1620)GTGfs	p.V540fs	HERC2_uc001zbl.1_Frame_Shift_Ins_p.V235fs	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	540	RCC1 1.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGCGGAGATCACCTTAGGCTCC	0.51																		7	54	---	---								C	28511101	-	C	28511100	7	5	88	1	0	1	1	0	0	0	0	0	7058	159	6	0	13209	0	HERC2	15	28511100	Frame_Shift_Ins	INS	-	TCGA-FJ-A3Z7-01A-12D-A23M-08	2925836	28511100	74020292	277	26475										
RYR3	6263	broad.mit.edu	37	chr15	33927868	33927868	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agatccgatttttccgggtaGagcgatcttatgcagtgaga	12	7	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:33927868G>A	uc001zhi.2	+	26	3299	c.3229G>A	c.(3229-3231)GAG>AAG	p.E1077K	RYR3_uc010bar.2_Missense_Mutation_p.E1077K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1077	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTTCCGGGTAGAGCGATCTTA	0.522													0	0	0	0.004007	0	14	31										A	33927868	G	A	33927868	3	1	88	1	0	0	0	0	1	0	0	0	13770	943	33	1	3331	1	RYR3	15	33927868	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5416768	33927868	68603524	278	26476										
ITPKA	3706	broad.mit.edu	37	chr15	41793928	41793928	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggctgatggctgacgcgctgCgcggctgcgtgcctgccttc	16	14	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:41793928C>T	uc001znz.2	+	3	693	c.682C>T	c.(682-684)CGC>TGC	p.R228C		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	228					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TGACGCGCTGCGCGGCTGCGT	0.682													0	0	0	0.014758	0	5	13										T	41793928	C	T	41793928	3	4	88	1	0	0	0	0	1	0	0	0	7917	768	27	2	692	2	ITPKA	15	41793928	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	7866060	41793928	60737464	279	26477										
SPTBN5	51332	broad.mit.edu	37	chr15	42143103	42143103	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctcagcctgctcttcggacgGtgctgcaaacaggatctctg	11	13	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:42143103G>A	uc001zos.2	-	66	11098	c.10765C>T	c.(10765-10767)CCG>TCG	p.P3589S		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3624	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCTTCGGACGGTGCTGCAAAC	0.682													0	0	0	0.004482	0	7	7										A	42143103	G	A	42143103	3	1	88	1	0	0	0	0	1	0	0	0	15121	1261	44	2	166	2	SPTBN5	15	42143103	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	349175	42143103	60388289	280	26478										
TP53BP1	7158	broad.mit.edu	37	chr15	43784619	43784619	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caggcaaggagtatcttgctGagagaaatctgaatccaact	10	8	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:43784619G>A	uc001zrs.2	-	2	188	c.40C>T	c.(40-42)CAG>TAG	p.Q14*	TP53BP1_uc010udp.1_Nonsense_Mutation_p.Q14*|TP53BP1_uc001zrq.3_Nonsense_Mutation_p.Q19*|TP53BP1_uc001zrr.3_Nonsense_Mutation_p.Q19*|TP53BP1_uc010udq.1_Nonsense_Mutation_p.Q19*	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	14					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTATCTTGCTGAGAGAAATCT	0.453								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.009718	0	43	153										A	43784619	G	A	43784619	4	1	88	1	0	0	0	0	0	1	0	0	16380	1299	45	1	5986	1	TP53BP1	15	43784619	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1641516	43784619	58746773	281	26479										
MAP1A	4130	broad.mit.edu	37	chr15	43816516	43816516	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aggaggagacagcaaacgtaGagatgtctgagaaactttgc	13	6	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:43816516G>C	uc001zrt.2	+	4	3312	c.2845G>C	c.(2845-2847)GAG>CAG	p.E949Q		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	949						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGCAAACGTAGAGATGTCTGA	0.517													0	0	0	0.007413	0	19	115										C	43816516	G	C	43816516	3	2	88	1	0	0	0	0	1	0	0	0	9227	943	33	1	2847	1	MAP1A	15	43816516	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	31897	43816516	58714876	282	26480										
UNC13C	440279	broad.mit.edu	37	chr15	54308011	54308011	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agccaaagagaattcgtcctTctttcaaagaagcagcttta	7	9	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:54308011T>A	uc002ack.2	+	1	2911	c.2911T>A	c.(2911-2913)TCT>ACT	p.S971T		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	971	Potential.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATTCGTCCTTCTTTCAAAGA	0.388													0	0	0	0.001984	0	5	13										A	54308011	T	A	54308011	3	1	88	1	0	0	0	0	1	0	0	0	16983	1783	62	5	2913	5	UNC13C	15	54308011	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	10491495	54308011	48223381	283	26481										
CELF6	60677	broad.mit.edu	37	chr15	72608198	72608198	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggacttacccctggcagggtCttctgctcgtgcagtgcact	12	13	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:72608198C>T	uc002auh.2	-	2	643	c.333G>A	c.(331-333)AAG>AAA	p.K111K	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Silent_p.K111K|CELF6_uc002aui.2_Missense_Mutation_p.D234N|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	111	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						CTGGCAGGGTCTTCTGCTCGT	0.637													0	0	0	0.004672	0	3	7										T	72608198	C	T	72608198	2	4	88	1	0	0	0	0	0	0	0	1	3220	912	32	1		1	CELF6	15	72608198	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	18300187	72608198	29923194	284	26482										
FURIN	5045	broad.mit.edu	37	chr15	91423194	91423194	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccccagcggaagtgcatcatCgacatcctcaccgagcccaa	8	17	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr15:91423194C>T	uc002bpu.1	+	12	1572	c.1356C>T	c.(1354-1356)ATC>ATT	p.I452I		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	452					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGTGCATCATCGACATCCTCA	0.667													0	0	0	0.001984	0	7	24										T	91423194	C	T	91423194	2	4	88	1	0	0	0	0	0	0	0	1	6099	874	31	1		1	FURIN	15	91423194	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	18814996	91423194	11108198	285	26483										
MSLNL	401827	broad.mit.edu	37	chr16	824500	824500	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctccagtgtccaggagccagGgggccttgtgcacagaatgg	15	11	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:824500G>A	uc002cjz.1	-	8	1741	c.1741C>T	c.(1741-1743)CCT>TCT	p.P581S		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	230	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CAGGAGCCAGGGGGCCTTGTG	0.716													0	0	0	0.006214	0	7	3										A	824500	G	A	824500	3	1	88	1	0	0	0	0	1	0	0	0	9882	1232	43	2	1456	2	MSLNL	16	824500	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		824500	89530253	286	26484										
ZSCAN10	84891	broad.mit.edu	37	chr16	3140353	3140353	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcagctggtgcgccttcaggCgagacagctgcgggaagctc	16	12	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:3140353C>T	uc002ctv.1	-	5	1005	c.917G>A	c.(916-918)CGC>CAC	p.R306H	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R224H|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R234H	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	306	C2H2-type 1.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGCCTTCAGGCGAGACAGCTG	0.642													0	0	0	0.007413	0	19	60										T	3140353	C	T	3140353	3	4	88	1	0	0	0	0	1	0	0	0	18224	768	27	2	1264	2	ZSCAN10	16	3140353	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2315853	3140353	87214400	287	26485										
ZNF263	10127	broad.mit.edu	37	chr16	3333838	3333838	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gatggcgtcgggcccgggctCccaggaacgggaagggctcc	18	13	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:3333838C>T	uc002cuq.2	+	1	352	c.20C>T	c.(19-21)TCC>TTC	p.S7F	ZNF263_uc010uww.1_Intron|ZNF263_uc002cup.2_Missense_Mutation_p.S7F	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	7					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						GGCCCGGGCTCCCAGGAACGG	0.682													0	0	0	0.004482	0	8	24										T	3333838	C	T	3333838	3	4	88	1	0	0	0	0	1	0	0	0	17800	855	30	1	22	1	ZNF263	16	3333838	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	193485	3333838	87020915	288	26486										
GRIN2A	2903	broad.mit.edu	37	chr16	9857275	9857275	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcatctcccaataaccaagcGttggtcatccctgtgggagt	10	12	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:9857275G>A	uc002czo.3	-	13	4674	c.4126C>T	c.(4126-4128)CGC>TGC	p.R1376C	GRIN2A_uc010uym.1_Missense_Mutation_p.R1376C|GRIN2A_uc010uyn.1_Silent_p.N1104N|GRIN2A_uc002czr.3_Silent_p.N1261N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1376	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATAACCAAGCGTTGGTCATCC	0.562													0	0	0	0.016723	0	13	80										A	9857275	G	A	9857275	3	1	88	1	0	0	0	0	1	0	0	0	6779	1145	40	2	272	2	GRIN2A	16	9857275	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	6523437	9857275	80497478	289	26487										
SMG1	23049	broad.mit.edu	37	chr16	18823360	18823360	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggtgcttggtggagtatcagCtgatgtagcaagattttttt	13	4	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:18823360C>G	uc002dfm.2	-	61	11074	c.10711G>C	c.(10711-10713)GCT>CCT	p.A3571P	SMG1_uc010bwb.2_Missense_Mutation_p.A3431P|SMG1_uc010bwa.2_Missense_Mutation_p.A2302P	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3571					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GGAGTATCAGCTGATGTAGCA	0.453													0	0	0	0.010729	0	10	66										G	18823360	C	G	18823360	3	3	88	1	0	0	0	0	1	0	0	0	14795	797	28	4	286	4	SMG1	16	18823360	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	8966085	18823360	71531393	290	26488										
CLN3	1201	broad.mit.edu	37	chr16	28489120	28489120	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcccaggagcccctcatacaGaatgatcaggaagacgaggt	11	11	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:28489120G>C	uc002dpo.2	-	14	1458	c.1135C>G	c.(1135-1137)CTG>GTG	p.L379V	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.L301V|CLN3_uc010vcu.1_Missense_Mutation_p.L279V|CLN3_uc002dpn.2_Missense_Mutation_p.L280V|CLN3_uc002dpm.2_Missense_Mutation_p.L325V|CLN3_uc010vcv.1_Missense_Mutation_p.L355V|CLN3_uc010byd.2_Intron|CLN3_uc002dpp.2_Missense_Mutation_p.L379V|CLN3_uc002dpt.1_Missense_Mutation_p.L279V|CLN3_uc002dpq.1_Missense_Mutation_p.L331V|CLN3_uc010bye.1_Missense_Mutation_p.L362V|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.L252V|CLN3_uc002dpu.1_Missense_Mutation_p.L277V	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	379					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						CCCTCATACAGAATGATCAGG	0.602													0	0	0	0.007413	0	19	76										C	28489120	G	C	28489120	3	2	88	1	0	0	0	0	1	0	0	0	3543	933	33	1	189	1	CLN3	16	28489120	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	9665760	28489120	61865633	291	26489										
APOB48R	55911	broad.mit.edu	37	chr16	28507766	28507766	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caggtagacctgcgtggtaaGgaggctgagatgaggcagga	18	6	0	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:28507766G>C	uc002dqb.1	+	3	1387	c.1377G>C	c.(1375-1377)AAG>AAC	p.K459N	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	459	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						TGCGTGGTAAGGAGGCTGAGA	0.642													0	0	0	0.004672	0	3	23										C	28507766	G	C	28507766	3	2	88	1	0	0	0	0	1	0	0	0	786	991	35	4	1387	4	APOB48R	16	28507766	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	18646	28507766	61846987	292	26490										
SALL1	6299	broad.mit.edu	37	chr16	51173970	51173970	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgtgtcctgtagtgcattttCaaggcgctctggcagctgag	13	9	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:51173970C>T	uc010vgs.1	-	2	2194	c.2163G>A	c.(2161-2163)TTG>TTA	p.L721L	SALL1_uc010vgr.1_Silent_p.L624L|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	721	C2H2-type 3.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			AGTGCATTTTCAAGGCGCTCT	0.517													0	0	0	0.013537	0	13	61										T	51173970	C	T	51173970	2	4	88	1	0	0	0	0	0	0	0	1	13810	825	29	1		1	SALL1	16	51173970	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	22666204	51173970	39180783	293	26491										
SALL1	6299	broad.mit.edu	37	chr16	51174338	51174338	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	taggtttcttgtggctgactCagggcccccggagtcacttt	12	11	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:51174338C>T	uc010vgs.1	-	2	1826	c.1795G>A	c.(1795-1797)GAG>AAG	p.E599K	SALL1_uc010vgr.1_Missense_Mutation_p.E502K|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	599					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTGGCTGACTCAGGGCCCCCG	0.602													0	0	0	0.006214	0	10	50										T	51174338	C	T	51174338	3	4	88	1	0	0	0	0	1	0	0	0	13810	835	29	1	2187	1	SALL1	16	51174338	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	368	51174338	39180415	294	26492										
CNGB1	1258	broad.mit.edu	37	chr16	58001085	58001085	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	attcggttctggttccacctCcgcctccatctctggctctg	8	16	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:58001085C>G	uc002emt.2	-	2	171	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	CNGB1_uc010cdh.2_Missense_Mutation_p.E36Q|CNGB1_uc002emu.2_Missense_Mutation_p.E36Q	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	36	Glu-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGTTCCACCTCCGCCTCCATC	0.652													0	0	0	0.020292	0	14	47										G	58001085	C	G	58001085	3	3	88	1	0	0	0	0	1	0	0	0	3600	864	30	1	3807	1	CNGB1	16	58001085	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	6826747	58001085	32353668	295	26493										
VAC14	55697	broad.mit.edu	37	chr16	70796903	70796903	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctgcacgatcccgtcgaggtGaagggtcactggggctcttt	14	11	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:70796903G>A	uc002ezm.2	-	11	1444	c.1186C>T	c.(1186-1188)CAC>TAC	p.H396Y	VAC14_uc010cfw.2_Missense_Mutation_p.H162Y|VAC14_uc002ezn.2_Intron|uc002ezp.1_Intron	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	396					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				CCGTCGAGGTGAAGGGTCACT	0.577													0	0	0	0.001984	0	6	30										A	70796903	G	A	70796903	3	1	88	1	0	0	0	0	1	0	0	0	17108	1290	45	1	1198	1	VAC14	16	70796903	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	12795818	70796903	19557850	296	26494										
FANCA	2175	broad.mit.edu	37	chr16	89809308	89809308	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagcagctgagagccagtccGggttgggtgctggggaggca	19	9	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:89809308G>A	uc002fou.1	-	37	3707	c.3665C>T	c.(3664-3666)CCG>CTG	p.P1222L	FANCA_uc010vpn.1_Missense_Mutation_p.P1222L|FANCA_uc010vpo.1_Missense_Mutation_p.P308L	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1222					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GAGCCAGTCCGGGTTGGGTGC	0.552			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.020292	0	14	31										A	89809308	G	A	89809308	3	1	88	1	0	0	0	0	1	0	0	0	5662	1116	39	2	730	2	FANCA	16	89809308	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	19012405	89809308	545445	297	26495										
DBNDD1	79007	broad.mit.edu	37	chr16	90075252	90075252	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcaaagacctcggccagctCctggtccgacatgtcggtga	12	13	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr16:90075252C>G	uc002fqf.1	-	3	447	c.259G>C	c.(259-261)GAG>CAG	p.E87Q	DBNDD1_uc002fqe.1_Missense_Mutation_p.E107Q|DBNDD1_uc002fqg.1_RNA	NM_001042610	NP_001036075	Q9H9R9	DBND1_HUMAN	dysbindin (dystrobrevin binding protein 1)	87						cytoplasm					0		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0275)		TCGGCCAGCTCCTGGTCCGAC	0.642													0	0	0	0.004672	0	3	14										G	90075252	C	G	90075252	3	3	88	1	0	0	0	0	1	0	0	0	4253	864	30	1	225	1	DBNDD1	16	90075252	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	265944	90075252	279501	298	26496										
P2RX1	5023	broad.mit.edu	37	chr17	3819557	3819557	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcagaactgagccccctgcaCggcctctgctctcagggtga	11	15	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:3819557C>T	uc002fww.2	-	1	404	c.-37G>A	c.(-39--35)CCGTG>CCATG		P2RX1_uc010ckm.1_Translation_Start_Site	NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1						platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		GCCCCCTGCACGGCCTCTGCT	0.677													0	0	0	0.010729	0	12	70										T	3819557	C	T	3819557	1	4	88	1	0	0	0	0	0	0	0	0	11339	551	19	2		2	P2RX1	17	3819557	Translation_Start_Site	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		3819557	77375653	299	26497										
KIF1C	10749	broad.mit.edu	37	chr17	4905823	4905823	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaaccccaagagtcggggttCtctgcgggtccgggagcacc	15	13	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:4905823C>G	uc002gan.1	+	7	820	c.494C>G	c.(493-495)TCT>TGT	p.S165C		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	165	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						AGTCGGGGTTCTCTGCGGGTC	0.547													0	0	0	0.01441	0	146	64										G	4905823	C	G	4905823	3	3	88	1	0	0	0	0	1	0	0	0	8285	913	32	1	512	1	KIF1C	17	4905823	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1086266	4905823	76289387	300	26498										
TP53	7157	broad.mit.edu	37	chr17	7574021	7574021	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcggaacatctcgaagcgctCacgcccacggatctgcagca	10	15	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:7574021C>A	uc002gim.2	-	10	1200	c.1006G>T	c.(1006-1008)GAG>TAG	p.E336*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.E204*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.E336*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	336	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.E336*(5)|p.I332fs*5(1)|p.E336fs*12(1)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGAAGCGCTCACGCCCACGG	0.438		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	5.61819e-17	0.027356	6.1417e-17	26	12										A	7574021	C	A	7574021	4	1	88	1	0	0	0	0	0	1	0	0	16378	835	29	3	183	3	TP53	17	7574021	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2668198	7574021	73621189	301	26499										
PIPOX	51268	broad.mit.edu	37	chr17	27370279	27370279	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gatctctgggacgccattgtGattggggcggggatccaggg	18	8	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:27370279G>A	uc002hdr.1	+	1	362	c.36G>A	c.(34-36)GTG>GTA	p.V12V		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	12	FAD (Potential).				tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	ACGCCATTGTGATTGGGGCGG	0.597													0	0	0	0.024245	0	15	60										A	27370279	G	A	27370279	2	1	88	1	0	0	0	0	0	0	0	1	11943	1277	45	1		1	PIPOX	17	27370279	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	19796258	27370279	53824931	302	26500										
TMEM132E	124842	broad.mit.edu	37	chr17	32955650	32955650	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggccagtggcatgtgacctCggagctgctgactggggcaa	16	10	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:32955650C>T	uc002hif.2	+	4	1125	c.797C>T	c.(796-798)TCG>TTG	p.S266L		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	266	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CATGTGACCTCGGAGCTGCTG	0.612													0	0	0	0.00308	0	7	38										T	32955650	C	T	32955650	3	4	88	1	0	0	0	0	1	0	0	0	16045	893	31	1	811	1	TMEM132E	17	32955650	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	5585371	32955650	48239560	303	26501										
GPR179	440435	broad.mit.edu	37	chr17	36484690	36484690	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gggacagatttctgttttggCaggtgttgcttcctgtgcct	13	8	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:36484690C>T	uc002hpz.2	-	11	4783	c.4762G>A	c.(4762-4764)GCC>ACC	p.A1588T		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1588	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TCTGTTTTGGCAGGTGTTGCT	0.502													0	0	0	0.01441	0	123	274										T	36484690	C	T	36484690	3	4	88	1	0	0	0	0	1	0	0	0	6674	710	25	2	2345	2	GPR179	17	36484690	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3529040	36484690	44710520	304	26502										
EIF1	10209	broad.mit.edu	37	chr17	39846394	39846394	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cggaatatggagaagtaattCagctacagggtgaccaacgc	12	8	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:39846394C>T	uc002hxj.2	+	3	414	c.250C>T	c.(250-252)CAG>TAG	p.Q84*	JUP_uc010wfs.1_Intron|EIF1_uc002hxk.2_RNA	NM_005801	NP_005792	P41567	EIF1_HUMAN	eukaryotic translation initiation factor 1	84					regulation of translational initiation|response to stress	cytoplasm	translation initiation factor activity				0		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			AGAAGTAATTCAGCTACAGGG	0.458													0	0	0	0.007413	0	15	108										T	39846394	C	T	39846394	4	4	88	1	0	0	0	0	0	1	0	0	4990	827	29	1	260	1	EIF1	17	39846394	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3361704	39846394	41348816	305	26503										
HAP1	9001	broad.mit.edu	37	chr17	39883363	39883363	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tagagacgttctgagctcctCagccagcgtctcctggaaac	10	13	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:39883363C>A	uc002hxm.1	-	10	1477	c.1465G>T	c.(1465-1467)GAG>TAG	p.E489*	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Nonsense_Mutation_p.E437*|HAP1_uc002hxo.1_Nonsense_Mutation_p.E420*|HAP1_uc002hxp.1_Nonsense_Mutation_p.E412*	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	489	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			CTGAGCTCCTCAGCCAGCGTC	0.577													1	0	0.004672	0.004672	0.004741	3	10										A	39883363	C	A	39883363	4	1	88	1	0	0	0	0	0	1	0	0	6953	835	29	3	562	3	HAP1	17	39883363	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	36969	39883363	41311847	306	26504										
GPATCH8	23131	broad.mit.edu	37	chr17	42475934	42475934	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgtctctgactgttcttgctCttcccccctttccaagccag	6	16	3	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:42475934C>T	uc002igw.1	-	8	3575	c.3511G>A	c.(3511-3513)GAG>AAG	p.E1171K	GPATCH8_uc002igv.1_Missense_Mutation_p.E1093K|GPATCH8_uc010wiz.1_Missense_Mutation_p.E1093K	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1171						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGTTCTTGCTCTTCCCCCCTT	0.517													0	0	0	0.023175	0	37	194										T	42475934	C	T	42475934	3	4	88	1	0	0	0	0	1	0	0	0	6594	922	32	1	1001	1	GPATCH8	17	42475934	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2592571	42475934	38719276	307	26505										
SP2	6668	broad.mit.edu	37	chr17	45993797	45993797	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atccagaatcccaccatgatCaacaaagggacccgatcaaa	6	13	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:45993797C>T	uc002imk.2	+	3	497	c.360C>T	c.(358-360)ATC>ATT	p.I120I	SP2_uc002iml.2_Silent_p.I113I|uc002imm.2_Intron	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	120					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0						CCACCATGATCAACAAAGGGA	0.507													0	0	0	0.012213	0	31	99										T	45993797	C	T	45993797	2	4	88	1	0	0	0	0	0	0	0	1	14964	816	29	1		1	SP2	17	45993797	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3517863	45993797	35201413	308	26506										
TTLL6	284076	broad.mit.edu	37	chr17	46865191	46865191	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accgggcatactcctcccgaGccctggaagcaacagtattc	9	15	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:46865191G>T	uc010wlo.1	-	12	1606	c.1571C>A	c.(1570-1572)GCT>GAT	p.A524D	TTLL6_uc002iob.2_Missense_Mutation_p.A217D|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.A277D|TTLL6_uc002iod.2_Missense_Mutation_p.A371D	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	476						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						CTCCTCCCGAGCCCTGGAAGC	0.532													1	0	1.50039e-11	0.012319	1.59665e-11	20	144										T	46865191	G	T	46865191	3	4	88	1	0	0	0	0	1	0	0	0	16728	971	34	4	1124	4	TTLL6	17	46865191	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	871394	46865191	34330019	309	26507										
ANKFN1	162282	broad.mit.edu	37	chr17	54450093	54450093	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtgaactgtctgcccaggtgGagaatgaaggattcactctg	13	8	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:54450093G>C	uc002iun.1	+	6	732	c.697G>C	c.(697-699)GAG>CAG	p.E233Q		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	233	Potential.									large_intestine(1)|ovary(1)	2						TGCCCAGGTGGAGAATGAAGG	0.512													0	0	0	0.008361	0	32	130										C	54450093	G	C	54450093	3	2	88	1	0	0	0	0	1	0	0	0	625	1175	41	1	719	1	ANKFN1	17	54450093	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	7584902	54450093	26745117	310	26508										
PRR11	55771	broad.mit.edu	37	chr17	57262920	57262920	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgcaagctccaggaagcactGaaggttggtattgtcaaata	11	7	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:57262920G>A	uc002ixf.1	+	4	478	c.399G>A	c.(397-399)CTG>CTA	p.L133L	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	133										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AGGAAGCACTGAAGGTTGGTA	0.224													0	0	0	0.020292	0	14	65										A	57262920	G	A	57262920	2	1	88	1	0	0	0	0	0	0	0	1	12583	1277	45	1		1	PRR11	17	57262920	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2812827	57262920	23932290	311	26509										
DHX40	79665	broad.mit.edu	37	chr17	57684430	57684430	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cgtcttaaagaaaatgcaaaGaagaaatgatgacaaatcca	7	6	1	5			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:57684430G>C	uc002ixn.1	+	18	2384	c.2237G>C	c.(2236-2238)AGA>ACA	p.R746T	DHX40_uc010woe.1_Missense_Mutation_p.R669T|DHX40_uc010wof.1_Missense_Mutation_p.R261T	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	746							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AAAATGCAAAGAAGAAATGAT	0.388													0	0	0	0.007413	0	19	79										C	57684430	G	C	57684430	3	2	88	1	0	0	0	0	1	0	0	0	4512	942	33	1	2307	1	DHX40	17	57684430	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	421510	57684430	23510780	312	26510										
KCNH6	81033	broad.mit.edu	37	chr17	61615899	61615899	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cgcgcgctagccgtcaagttCaagaccacccacgcgccgcc	10	19	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:61615899C>G	uc002jay.2	+	8	1910	c.1830C>G	c.(1828-1830)TTC>TTG	p.F610L	KCNH6_uc010wpl.1_Missense_Mutation_p.F487L|KCNH6_uc010wpm.1_Missense_Mutation_p.F610L|KCNH6_uc002jaz.1_Missense_Mutation_p.F557L	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	610	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CCGTCAAGTTCAAGACCACCC	0.677													0	0	0	0.006214	0	10	9										G	61615899	C	G	61615899	3	3	88	1	0	0	0	0	1	0	0	0	8036	825	29	1	1860	1	KCNH6	17	61615899	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3931469	61615899	19579311	313	26511										
STRADA	92335	broad.mit.edu	37	chr17	61784042	61784042	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gacatggccgttggccagttCacaggctgtgattcccacac	11	13	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:61784042C>T	uc002jbm.2	-	10	970	c.811G>A	c.(811-813)GAA>AAA	p.E271K	STRADA_uc002jbn.2_Missense_Mutation_p.E213K|STRADA_uc002jbo.2_Missense_Mutation_p.E234K|STRADA_uc002jbp.2_Missense_Mutation_p.E234K|STRADA_uc002jbq.2_Missense_Mutation_p.E213K|STRADA_uc010wpq.1_Missense_Mutation_p.E227K|STRADA_uc010wpr.1_Missense_Mutation_p.E242K|STRADA_uc010ddw.2_Missense_Mutation_p.E242K|STRADA_uc002jbr.2_Missense_Mutation_p.E210K	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	271	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						TTGGCCAGTTCACAGGCTGTG	0.488													0	0	0	0.00874	0	39	203										T	61784042	C	T	61784042	3	4	88	1	0	0	0	0	1	0	0	0	15323	835	29	1	558	1	STRADA	17	61784042	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	168143	61784042	19411168	314	26512										
CACNG4	27092	broad.mit.edu	37	chr17	64961111	64961111	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcgctcatggccatcgccatCggcaccgactactggctgta	10	15	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:64961111C>T	uc002jft.1	+	1	99	c.84C>T	c.(82-84)ATC>ATT	p.I28I		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	28	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			CCATCGCCATCGGCACCGACT	0.552													0	0	0	0.006214	0	8	21										T	64961111	C	T	64961111	2	4	88	1	0	0	0	0	0	0	0	1	2559	874	31	1		1	CACNG4	17	64961111	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3177069	64961111	16234099	315	26513										
NOL11	25926	broad.mit.edu	37	chr17	65733721	65733721	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cattggggacacagtaacagGacttctggaaaggtgtaaag	13	6	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:65733721G>T	uc002jgd.1	+	12	1319	c.1316G>T	c.(1315-1317)GGA>GTA	p.G439V	NOL11_uc010wql.1_Missense_Mutation_p.G257V|NOL11_uc010deu.1_Missense_Mutation_p.G34V	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	439						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			ACAGTAACAGGACTTCTGGAA	0.423													1	0	1.3466e-33	0.01441	1.49588e-33	85	175										T	65733721	G	T	65733721	3	4	88	1	0	0	0	0	1	0	0	0	10521	1174	41	3	1362	3	NOL11	17	65733721	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	772610	65733721	15461489	316	26514										
BPTF	2186	broad.mit.edu	37	chr17	65908180	65908180	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaaagaataatgaaaatcgaGagtctgaaaagaaaggacag	10	3	1	5			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr17:65908180G>C	uc002jgf.2	+	11	4241	c.4180G>C	c.(4180-4182)GAG>CAG	p.E1394Q	BPTF_uc002jge.2_Missense_Mutation_p.E1520Q	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1520					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGAAAATCGAGAGTCTGAAAA	0.299													0	0	0	0.014323	0	23	71										C	65908180	G	C	65908180	3	2	88	1	0	0	0	0	1	0	0	0	1495	943	33	1	4608	1	BPTF	17	65908180	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	174459	65908180	15287030	317	26515										
METTL4	64863	broad.mit.edu	37	chr18	2544739	2544739	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gagaatctaatgggaacacaAattctcctgaattggttatc	8	7	2	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:2544739A>C	uc002klh.3	-	7	1874	c.1094T>G	c.(1093-1095)TTT>TGT	p.F365C	METTL4_uc010dkj.2_Intron	NM_022840	NP_073751	Q8N3J2	METL4_HUMAN	methyltransferase like 4	365					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			kidney(1)|skin(1)	2						TGGGAACACAAATTCTCCTGA	0.403													0	0	0	0.021523	0	22	82										C	2544739	A	C	2544739	3	2	88	1	0	0	0	0	1	0	0	0	9502	14	1	5	336	5	METTL4	18	2544739	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08		2544739	75532509	318	26516										
LAMA3	3909	broad.mit.edu	37	chr18	21485566	21485566	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctgttaaatgaagccaagatGacacaaaagaagctaaagca	8	7	0	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:21485566G>A	uc002kuq.2	+	52	6782	c.6696G>A	c.(6694-6696)ATG>ATA	p.M2232I	LAMA3_uc002kur.2_Missense_Mutation_p.M2176I|LAMA3_uc002kus.3_Missense_Mutation_p.M623I|LAMA3_uc002kut.3_Missense_Mutation_p.M567I	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2232	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGCCAAGATGACACAAAAGA	0.448													0	0	0	0.010771	0	44	98										A	21485566	G	A	21485566	3	1	88	1	0	0	0	0	1	0	0	0	8607	1290	45	1	7077	1	LAMA3	18	21485566	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	18940827	21485566	56591682	319	26517										
CDH2	1000	broad.mit.edu	37	chr18	25593832	25593832	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atctgcaggctcactgctctCatattgtacttttctttttc	5	11	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:25593832C>G	uc002kwg.2	-	3	673	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	CDH2_uc010xbn.1_Missense_Mutation_p.E41Q	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	72					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						TCACTGCTCTCATATTGTACT	0.368													0	0	0	0.00632	0	29	69										G	25593832	C	G	25593832	3	3	88	1	0	0	0	0	1	0	0	0	3105	835	29	1	2562	1	CDH2	18	25593832	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4108266	25593832	52483416	320	26518										
PIK3C3	5289	broad.mit.edu	37	chr18	39584503	39584503	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggttgcgacaggccgatgatGaggtgcattattatttatta	12	5	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:39584503G>A	uc002lap.2	+	10	1226	c.1168G>A	c.(1168-1170)GAG>AAG	p.E390K	PIK3C3_uc010xcl.1_Missense_Mutation_p.E327K	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	390					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						GGCCGATGATGAGGTGCATTA	0.443										TSP Lung(28;0.18)			0	0	0	0.001984	0	7	32										A	39584503	G	A	39584503	3	1	88	1	0	0	0	0	1	0	0	0	11912	1291	45	1	1206	1	PIK3C3	18	39584503	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	13990671	39584503	38492745	321	26519										
RNF165	494470	broad.mit.edu	37	chr18	44030341	44030341	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaatcccagcagacacacctCcgccgtacgggagagctatg	10	14	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:44030341C>T	uc002lcb.1	+	5	749	c.698C>T	c.(697-699)TCC>TTC	p.S233F	RNF165_uc002lby.1_Missense_Mutation_p.S166F|RNF165_uc010dnn.1_Missense_Mutation_p.S29F	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	233							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		AGACACACCTCCGCCGTACGG	0.517													0	0	0	0.008871	0	18	87										T	44030341	C	T	44030341	3	4	88	1	0	0	0	0	1	0	0	0	13456	855	30	1	716	1	RNF165	18	44030341	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4445838	44030341	34046907	322	26520										
WDR7	23335	broad.mit.edu	37	chr18	54688024	54688024	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctgcagtggcttttgctcctGatggaagatatcttgccacc	10	11	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:54688024G>A	uc002lgk.1	+	27	4424	c.4213G>A	c.(4213-4215)GAT>AAT	p.D1405N	WDR7_uc002lgl.1_Missense_Mutation_p.D1372N	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1405	WD 9.									ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TTTTGCTCCTGATGGAAGATA	0.408													0	0	0	0.023175	0	34	143										A	54688024	G	A	54688024	3	1	88	1	0	0	0	0	1	0	0	0	17317	1290	45	1	4315	1	WDR7	18	54688024	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	10657683	54688024	23389224	323	26521										
KCNG2	26251	broad.mit.edu	37	chr18	77659691	77659691	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agcagcgcgcggccagccccGagccggccctgcaggaggac	16	17	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr18:77659691G>A	uc010xfl.1	+	2	1276	c.1276G>A	c.(1276-1278)GAG>AAG	p.E426K		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	426	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		GGCCAGCCCCGAGCCGGCCCT	0.706													0	0	0	0.016723	0	10	13										A	77659691	G	A	77659691	3	1	88	1	0	0	0	0	1	0	0	0	8028	1059	37	1	1282	1	KCNG2	18	77659691	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	22971667	77659691	417557	324	26522										
SEMA6B	10501	broad.mit.edu	37	chr19	4548448	4548448	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acgtccacagccactcgagtCagctggtgcctgggggacag	14	13	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:4548448C>G	uc010duc.1	-	12	1319	c.1281G>C	c.(1279-1281)CTG>CTC	p.L427L	SEMA6B_uc010dud.2_Silent_p.L427L|SEMA6B_uc010xih.1_Silent_p.L427L	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	427	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACTCGAGTCAGCTGGTGCC	0.652													0	0	0	0.008871	0	19	22										G	4548448	C	G	4548448	2	3	88	1	0	0	0	0	0	0	0	1	14040	813	29	1		1	SEMA6B	19	4548448	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		4548448	54580535	325	26523										
C3	718	broad.mit.edu	37	chr19	6707129	6707129	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggcccgcgcgtgctgccgccGcagctctgtgatgtagttgc	15	14	1	1	rs117793540	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:6707129G>A	uc002mfm.2	-	17	2265	c.2203C>T	c.(2203-2205)CGG>TGG	p.R735W		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	735			R -> W (in AHUS5).		complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGCTGCCGCCGCAGCTCTGTG	0.687													0	0	0	0.016723	0	13	33										A	6707129	G	A	6707129	3	1	88	1	0	0	0	0	1	0	0	0	2204	1086	38	2	2888	2	C3	19	6707129	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2158681	6707129	52421854	326	26524										
GPR108	56927	broad.mit.edu	37	chr19	6731089	6731089	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaacttgtagcccgtgagcaCgaagaaggccagggtggagc	16	9	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:6731089C>T	uc002mfp.2	-	17	1514	c.1468G>A	c.(1468-1470)GTG>ATG	p.V490M	GPR108_uc010duv.2_Missense_Mutation_p.V41M|GPR108_uc002mfn.2_Missense_Mutation_p.V145M|GPR108_uc002mfo.3_Missense_Mutation_p.V248M|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	490	Helical; Name=7; (Potential).					integral to membrane					0						CCCGTGAGCACGAAGAAGGCC	0.677													0	0	0	0.001984	0	7	27										T	6731089	C	T	6731089	3	4	88	1	0	0	0	0	1	0	0	0	6624	536	19	2	171	2	GPR108	19	6731089	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	23960	6731089	52397894	327	26525										
KRI1	65095	broad.mit.edu	37	chr19	10670351	10670351	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcgctcatccttacggcgcaCggaggacgcgatgctgcgtg	15	13	1	0	rs45518133	byFrequency	TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:10670351C>T	uc002moy.1	-	11	988	c.979G>A	c.(979-981)GTG>ATG	p.V327M	KRI1_uc002mow.1_Translation_Start_Site|KRI1_uc002mox.1_Missense_Mutation_p.V323M	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	327	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			TTACGGCGCACGGAGGACGCG	0.622													0	0	0	0.016522	0	24	82										T	10670351	C	T	10670351	3	4	88	1	0	0	0	0	1	0	0	0	8444	536	19	2	1186	2	KRI1	19	10670351	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	3939262	10670351	48458632	328	26526										
DHPS	1725	broad.mit.edu	37	chr19	12792434	12792434	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcttggaagccggtggtgccGaaggcctccagcagtgcgcg	17	12	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:12792434G>T	uc002muh.1	-	1	244	c.147C>A	c.(145-147)TTC>TTA	p.F49L	DHPS_uc002muf.1_5'Flank|DHPS_uc002mug.1_5'Flank|DHPS_uc002mui.1_Missense_Mutation_p.F49L|DHPS_uc002muj.1_Missense_Mutation_p.F49L|DHPS_uc002muk.1_RNA|DHPS_uc010xmn.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	49					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	CGGTGGTGCCGAAGGCCTCCA	0.632													1	0	6.31663e-08	0.024245	6.5764e-08	14	44										T	12792434	G	T	12792434	3	4	88	1	0	0	0	0	1	0	0	0	4485	1049	37	3	998	3	DHPS	19	12792434	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2122083	12792434	46336549	329	26527										
ASNA1	439	broad.mit.edu	37	chr19	12856314	12856314	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catttcccggcatcgatgagGccatgagctatgccgaggtc	12	12	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:12856314G>T	uc002muv.2	+	3	447	c.433G>T	c.(433-435)GCC>TCC	p.A145S	ASNA1_uc002muw.2_Missense_Mutation_p.A144S	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	145					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			ovary(2)	2					Adenosine triphosphate(DB00171)	CATCGATGAGGCCATGAGCTA	0.627													1	0	8.28177e-16	0.007413	8.97192e-16	20	55										T	12856314	G	T	12856314	3	4	88	1	0	0	0	0	1	0	0	0	1047	1203	42	4	443	4	ASNA1	19	12856314	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	63880	12856314	46272669	330	26528										
BEST2	54831	broad.mit.edu	37	chr19	12863496	12863496	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggcgtgggagcatctacaaActcctgtggcgagagctgct	14	10	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:12863496A>T	uc002mux.2	+	1	90	c.90A>T	c.(88-90)AAA>AAT	p.K30N		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	30	Helical; (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						GCATCTACAAACTCCTGTGGC	0.527													0	0	0	0.007413	0	18	31										T	12863496	A	T	12863496	3	4	88	1	0	0	0	0	1	0	0	0	1405	40	2	5	92	5	BEST2	19	12863496	Missense_Mutation	SNP	A	TCGA-FJ-A3Z7-01A-12D-A23M-08	7182	12863496	46265487	331	26529										
C19orf57	79173	broad.mit.edu	37	chr19	14000730	14000730	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctacccatcctgctgggggtCtgctgggggtcaggggagcc	17	12	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:14000730C>G	uc002mxl.1	-	6	998	c.939G>C	c.(937-939)CAG>CAC	p.Q313H	C19orf57_uc002mxk.1_Missense_Mutation_p.Q195H|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	313					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGCTGGGGGTCTGCTGGGGGT	0.657													0	0	0	0.024245	0	15	21										G	14000730	C	G	14000730	3	3	88	1	0	0	0	0	1	0	0	0	1939	912	32	1	986	1	C19orf57	19	14000730	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1137234	14000730	45128253	332	26530										
EPHX3	79852	broad.mit.edu	37	chr19	15338451	15338451	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	caatgtgggtgtggtcagctCctggggttccagggggaagt	18	7	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:15338451C>G	uc002nap.2	-	7	1089	c.880G>C	c.(880-882)GAG>CAG	p.E294Q	EPHX3_uc002naq.2_Missense_Mutation_p.E294Q	NM_024794	NP_079070	Q9H6B9	EPHX3_HUMAN	abhydrolase domain containing 9 precursor	294						extracellular region	hydrolase activity				0						GTGGTCAGCTCCTGGGGTTCC	0.532													0	0	0	0.001984	0	7	39										G	15338451	C	G	15338451	3	3	88	1	0	0	0	0	1	0	0	0	5181	864	30	1	206	1	EPHX3	19	15338451	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1337721	15338451	43790532	333	26531										
IL12RB1	3594	broad.mit.edu	37	chr19	18174691	18174691	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	accccctccactcaccgatgCtgaagcgctggggctggctc	11	17	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:18174691C>G	uc002nhw.1	-	13	1677	c.1613G>C	c.(1612-1614)AGC>ACC	p.S538T	IL12RB1_uc010xqb.1_Missense_Mutation_p.S538T|IL12RB1_uc002nhx.1_Missense_Mutation_p.S578T	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	538	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CTCACCGATGCTGAAGCGCTG	0.617													0	0	0	0.009096	0	3	29										G	18174691	C	G	18174691	3	3	88	1	0	0	0	0	1	0	0	0	7626	797	28	4	395	4	IL12RB1	19	18174691	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2836240	18174691	40954292	334	26532										
LSM14A	26065	broad.mit.edu	37	chr19	34685411	34685411	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tttggtacagaagacagaccGacagatcgtccaataccacc	8	12	0	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:34685411G>A	uc002nvb.3	+	2	346	c.150G>A	c.(148-150)CCG>CCA	p.P50P	LSM14A_uc002nva.3_Silent_p.P50P|LSM14A_uc010xru.1_Silent_p.P50P	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	LSM14 homolog A isoform a	50					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)					AAGACAGACCGACAGATCGTC	0.423													0	0	0	0.023175	0	35	197										A	34685411	G	A	34685411	2	1	88	1	0	0	0	0	0	0	0	1	9054	1045	37	1		1	LSM14A	19	34685411	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	16510720	34685411	24443572	335	26533										
MLL4	9757	broad.mit.edu	37	chr19	36212267	36212267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tactcctcctcctcttggggCtcctgaagcccctgagccag	9	17	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:36212267C>T	uc010eei.2	+	3	2018	c.2018C>T	c.(2017-2019)GCT>GTT	p.A673V		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	673	Pro-rich.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTCTTGGGGCTCCTGAAGCC	0.622													0	0	0	0.014758	0	5	6										T	36212267	C	T	36212267	3	4	88	1	0	0	0	0	1	0	0	0	9623	797	28	2	2028	2	MLL4	19	36212267	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1526856	36212267	22916716	336	26534										
ZNF146	7705	broad.mit.edu	37	chr19	36727428	36727428	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaaagtcttcagccacaaatCaaacctcactgagcatgagc	6	12	4	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:36727428C>G	uc002odq.3	+	4	1609	c.86C>G	c.(85-87)TCA>TGA	p.S29*	ZNF146_uc010eet.2_Nonsense_Mutation_p.S29*|ZNF146_uc010eeu.2_Nonsense_Mutation_p.S29*	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	29	C2H2-type 1.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					AGCCACAAATCAAACCTCACT	0.423													0	0	0	0.016522	0	23	76										G	36727428	C	G	36727428	4	3	88	1	0	0	0	0	0	1	0	0	17730	838	29	1	88	1	ZNF146	19	36727428	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	515161	36727428	22401555	337	26535										
ZNF146	7705	broad.mit.edu	37	chr19	36728021	36728021	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccttctctcagagctcatctCtcactgtgcatgtgagaagc	8	13	5	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:36728021C>G	uc002odq.3	+	4	2202	c.679C>G	c.(679-681)CTC>GTC	p.L227V	ZNF146_uc010eet.2_Missense_Mutation_p.L227V|ZNF146_uc010eeu.2_Missense_Mutation_p.L227V	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	227	Interaction with TERF2IP.|C2H2-type 8.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GAGCTCATCTCTCACTGTGCA	0.443													0	0	0	0.014323	0	21	154										G	36728021	C	G	36728021	3	3	88	1	0	0	0	0	1	0	0	0	17730	913	32	1	681	1	ZNF146	19	36728021	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	593	36728021	22400962	338	26536										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41770565	41770565	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gggagctcgacgccgacgacGaaccggggcgacccgggcac	17	15	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:41770565G>C	uc002oqb.3	+	1	446	c.157G>C	c.(157-159)GAA>CAA	p.E53Q	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Intron|HNRNPUL1_uc002oqa.3_Intron|HNRNPUL1_uc010ehm.2_Missense_Mutation_p.E53Q|HNRNPUL1_uc002oqc.3_Intron|HNRNPUL1_uc002oqe.3_Missense_Mutation_p.E53Q|HNRNPUL1_uc002oqd.3_5'UTR|HNRNPUL1_uc010ehn.2_5'Flank|HNRNPUL1_uc010eho.2_5'Flank|HNRNPUL1_uc010xvy.1_5'Flank|HNRNPUL1_uc010ehl.1_Intron	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	53	Necessary for interaction with HRMT1L1.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CGCCGACGACGAACCGGGGCG	0.736													0	0	0	0.004482	0	6	19										C	41770565	G	C	41770565	3	2	88	1	0	0	0	0	1	0	0	0	7274	1059	37	1	159	1	HNRNPUL1	19	41770565	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5042544	41770565	17358418	339	26537										
LIPE	3991	broad.mit.edu	37	chr19	42930623	42930623	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctcagaatctgtgacccactCagaaagtgccttccactcta	6	14	4	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:42930623C>T	uc002otr.2	-	1	956	c.679G>A	c.(679-681)GAG>AAG	p.E227K	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	227					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GTGACCCACTCAGAAAGTGCC	0.493													0	0	0	0.01441	0	90	71										T	42930623	C	T	42930623	3	4	88	1	0	0	0	0	1	0	0	0	8821	835	29	1	2591	1	LIPE	19	42930623	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1160058	42930623	16198360	340	26538										
NLRP4	147945	broad.mit.edu	37	chr19	56382202	56382202	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgtccccataggttggctttCtgccacctcagcgagcagtg	11	13	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr19:56382202C>T	uc002qmd.3	+	7	2786	c.2364C>T	c.(2362-2364)TTC>TTT	p.F788F	NLRP4_uc002qmf.2_Silent_p.F713F|NLRP4_uc010etf.2_Silent_p.F563F	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	788							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GGTTGGCTTTCTGCCACCTCA	0.483													0	0	0	0.01441	0	59	48										T	56382202	C	T	56382202	2	4	88	1	0	0	0	0	0	0	0	1	10479	912	32	1		1	NLRP4	19	56382202	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	13451579	56382202	2746781	341	26539										
TGM3	7053	broad.mit.edu	37	chr20	2320505	2320505	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccctctcccccataggtgctGaacgaggctcgtgtgcggaa	12	14	1	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:2320505G>A	uc002wfx.3	+	12	1903	c.1806G>A	c.(1804-1806)CTG>CTA	p.L602L		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	602					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	CATAGGTGCTGAACGAGGCTC	0.637													0	0	0	0.00308	0	6	17										A	2320505	G	A	2320505	2	1	88	1	0	0	0	0	0	0	0	1	15828	1277	45	1		1	TGM3	20	2320505	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		2320505	60705015	342	26540										
FAM113A	64773	broad.mit.edu	37	chr20	2819730	2819730	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gttcaaagctcagctcccccTacccaccccccccaccctac	3	24	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:2819730T>C	uc002wgz.1	-	4	702	c.205_splice	c.e4-1	p.G69_splice	FAM113A_uc002whb.1_Intron|FAM113A_uc002wha.1_Splice_Site|FAM113A_uc010zqa.1_5'UTR|FAM113A_uc002whc.1_Intron|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773								hydrolase activity|protein binding			ovary(2)	2						CAGCTCCCCCTACCCACCCCC	0.652													0	0	0	0.009096	0	3	19										C	2819730	T	C	2819730	5	2	88	1	0	0	0	0	0	0	1	0	5401	1536	53	5	1181	5	FAM113A	20	2819730	Splice_Site	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	499225	2819730	60205790	343	26541										
TRMT6	51605	broad.mit.edu	37	chr20	5923084	5923084	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcatccttacataatcttttTtgcttcctctctctttaggc	4	12	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:5923084T>C	uc002wmh.1	-	7	1138	c.1016A>G	c.(1015-1017)AAA>AGA	p.K339R	TRMT6_uc010zra.1_Missense_Mutation_p.K169R|TRMT6_uc010gbn.1_Missense_Mutation_p.K169R|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	339					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						ATAATCTTTTTTGCTTCCTCT	0.453													0	0	0	0.01441	0	78	50										C	5923084	T	C	5923084	3	2	88	1	0	0	0	0	1	0	0	0	16565	1841	64	5	497	5	TRMT6	20	5923084	Missense_Mutation	SNP	T	TCGA-FJ-A3Z7-01A-12D-A23M-08	3103354	5923084	57102436	344	26542										
RRBP1	6238	broad.mit.edu	37	chr20	17599273	17599273	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	atcgctctgtttctgggcttCgctcttggcggcatcgagct	12	12	3	0	rs149077359		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:17599273C>T	uc002wpv.1	-	21	2782	c.2428G>A	c.(2428-2430)GAA>AAA	p.E810K	RRBP1_uc010zrp.1_5'UTR|RRBP1_uc002wpt.1_Missense_Mutation_p.E180K|RRBP1_uc002wpu.2_Missense_Mutation_p.E584K|RRBP1_uc002wpw.1_Missense_Mutation_p.E810K|RRBP1_uc010gcl.1_Missense_Mutation_p.E584K	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1243	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						TTCTGGGCTTCGCTCTTGGCG	0.552													0	0	0	0.016522	0	22	50										T	17599273	C	T	17599273	3	4	88	1	0	0	0	0	1	0	0	0	13678	893	31	1	529	1	RRBP1	20	17599273	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	11676189	17599273	45426247	345	26543										
SLC24A3	57419	broad.mit.edu	37	chr20	19566112	19566112	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	catcaccaaaggcgatgtggGagttggcaccatcgtgggct	14	10	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:19566112G>C	uc002wrl.2	+	6	733	c.536G>C	c.(535-537)GGA>GCA	p.G179A		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	179	Extracellular (Potential).|Alpha-1.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						GGCGATGTGGGAGTTGGCACC	0.547													0	0	0	0.011902	0	42	154										C	19566112	G	C	19566112	3	2	88	1	0	0	0	0	1	0	0	0	14467	1174	41	1	558	1	SLC24A3	20	19566112	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1966839	19566112	43459408	346	26544										
C20orf185	359710	broad.mit.edu	37	chr20	31654681	31654681	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acctggcagctttgctccctGaggtgagtgacgctctcatg	12	12	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:31654681G>A	uc002wym.1	+	9	976	c.976G>A	c.(976-978)GAG>AAG	p.E326K		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	326					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						TTTGCTCCCTGAGGTGAGTGA	0.358													0	0	0	0.008361	0	29	93										A	31654681	G	A	31654681	3	1	88	1	0	0	0	0	1	0	0	0	2097	1291	45	1	1010	1	C20orf185	20	31654681	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	12088569	31654681	31370839	347	26545										
TOP1	7150	broad.mit.edu	37	chr20	39741425	39741425	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggtttgggtctttacagggtGagaaggactggcagaaatac	15	5	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:39741425G>A	uc002xjl.2	+	14	1558	c.1312G>A	c.(1312-1314)GAG>AAG	p.E438K	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	438					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TTTACAGGGTGAGAAGGACTG	0.373			T	NUP98	AML*								0	0	0	0.00308	0	8	53										A	39741425	G	A	39741425	3	1	88	1	0	0	0	0	1	0	0	0	16360	1291	45	1	1366	1	TOP1	20	39741425	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	8086744	39741425	23284095	348	26546										
NCOA5	57727	broad.mit.edu	37	chr20	44692158	44692158	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcccccacgcactccctcctCagggcctcctctctctcttt	5	22	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:44692158C>T	uc002xrd.2	-	6	1519	c.991G>A	c.(991-993)GAG>AAG	p.E331K	NCOA5_uc002xrc.2_Missense_Mutation_p.E219K|NCOA5_uc002xre.2_Missense_Mutation_p.E331K	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				ACTCCCTCCTCAGGGCCTCCT	0.577													0	0	0	0.001984	0	7	63										T	44692158	C	T	44692158	3	4	88	1	0	0	0	0	1	0	0	0	10232	835	29	1	756	1	NCOA5	20	44692158	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4950733	44692158	18333362	349	26547										
ZNFX1	57169	broad.mit.edu	37	chr20	47887564	47887564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcatggaagtttcctgcacaGagctggcagggaagacactt	13	9	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:47887564G>C	uc002xui.2	-	3	1032	c.785C>G	c.(784-786)TCT>TGT	p.S262C		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	262							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTCCTGCACAGAGCTGGCAGG	0.507													0	0	0	0.021523	0	26	107										C	47887564	G	C	47887564	3	2	88	1	0	0	0	0	1	0	0	0	18202	942	33	1	5019	1	ZNFX1	20	47887564	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	3195406	47887564	15137956	350	26548										
ZNF831	128611	broad.mit.edu	37	chr20	57828035	57828035	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtgcctctccccttgcaggtCtgaatctgcaagaggagcca	11	13	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:57828035C>G	uc002yan.2	+	4	4030	c.4030C>G	c.(4030-4032)CTG>GTG	p.L1344V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1344						intracellular	nucleic acid binding|zinc ion binding	p.L1344L(1)		skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCTTGCAGGTCTGAATCTGCA	0.458													0	0	0	0.01892	0	25	57										G	57828035	C	G	57828035	3	3	88	1	0	0	0	0	1	0	0	0	18182	912	32	1	4044	1	ZNF831	20	57828035	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	9940471	57828035	5197485	351	26549										
ZNF831	128611	broad.mit.edu	37	chr20	57829687	57829687	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cccatagaaattcctgaagcCccttctaaatccctcaagaa	4	14	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:57829687C>T	uc002yan.2	+	5	4923	c.4923C>T	c.(4921-4923)GCC>GCT	p.A1641A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1641						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TTCCTGAAGCCCCTTCTAAAT	0.463													0	0	0	0.01441	0	48	88										T	57829687	C	T	57829687	2	4	88	1	0	0	0	0	0	0	0	1	18182	610	22	2		2	ZNF831	20	57829687	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1652	57829687	5195833	352	26550										
LSM14B	149986	broad.mit.edu	37	chr20	60704841	60704841	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tcctcccctcctcaattcagGagctggttttccatccatcc	5	17	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:60704841G>A	uc010gjy.1	+	4	634	c.428G>A	c.(427-429)GGA>GAA	p.G143E	LSM14B_uc010gjx.1_Missense_Mutation_p.G169E|LSM14B_uc002ybv.2_Missense_Mutation_p.G143E|LSM14B_uc010gjz.1_Missense_Mutation_p.G99E|LSM14B_uc010zzz.1_Missense_Mutation_p.G63E	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	143					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CTCAATTCAGGAGCTGGTTTT	0.498													0	0	0	0.014758	0	5	6										A	60704841	G	A	60704841	3	1	88	1	0	0	0	0	1	0	0	0	9055	1188	41	1	442	1	LSM14B	20	60704841	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	2875154	60704841	2320679	353	26551										
LAMA5	3911	broad.mit.edu	37	chr20	60908513	60908513	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gagcgccgcctcgtagtatgCgctaggcagcagaaccacgt	13	13	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr20:60908513C>T	uc002ycq.2	-	25	3113	c.3046G>A	c.(3046-3048)GCA>ACA	p.A1016T		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1016	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGTAGTATGCGCTAGGCAGC	0.682													0	0	0	0.014758	0	5	29										T	60908513	C	T	60908513	3	4	88	1	0	0	0	0	1	0	0	0	8609	768	27	2	8265	2	LAMA5	20	60908513	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	203672	60908513	2117007	354	26552										
TIAM1	7074	broad.mit.edu	37	chr21	32559388	32559388	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gaataccatcttcttccacaGaagaaagtgaaaaccctgtg	7	10	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:32559388G>A	uc002yow.1	-	15	3063	c.2591C>T	c.(2590-2592)TCT>TTT	p.S864F	TIAM1_uc011adk.1_Missense_Mutation_p.S864F|TIAM1_uc011adl.1_Missense_Mutation_p.S804F	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	864	PDZ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TTCTTCCACAGAAGAAAGTGA	0.458													0	0	0	0.01441	0	44	334										A	32559388	G	A	32559388	3	1	88	1	0	0	0	0	1	0	0	0	15887	942	33	1	2244	1	TIAM1	21	32559388	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		32559388	15570507	355	26553										
HUNK	30811	broad.mit.edu	37	chr21	33296930	33296930	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aaacggaaaacagctactacCtggtcatggagctgtgccct	10	11	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:33296930C>T	uc002yph.2	+	2	772	c.412C>T	c.(412-414)CTG>TTG	p.L138L		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	138	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CAGCTACTACCTGGTCATGGA	0.532													0	0	0	0.011902	0	42	150										T	33296930	C	T	33296930	2	4	88	1	0	0	0	0	0	0	0	1	7458	680	24	2		2	HUNK	21	33296930	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	737542	33296930	14832965	356	26554										
MORC3	23515	broad.mit.edu	37	chr21	37741729	37741729	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccaggaaaccaccgataaatCtgcagatgatgcaggctgcc	10	12	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:37741729C>T	uc002yvi.2	+	15	2139	c.2063C>T	c.(2062-2064)TCT>TTT	p.S688F		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	688	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						ACCGATAAATCTGCAGATGAT	0.413													0	0	0	0.01441	0	48	37										T	37741729	C	T	37741729	3	4	88	1	0	0	0	0	1	0	0	0	9703	913	32	1	2121	1	MORC3	21	37741729	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4444799	37741729	10388166	357	26555										
TTC3	7267	broad.mit.edu	37	chr21	38461129	38461129	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcttctgagataaatttgaaGaaactacaacatcttgagtt	7	6	2	4			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:38461129G>T	uc002yvz.2	+	5	474	c.369G>T	c.(367-369)AAG>AAT	p.K123N	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Missense_Mutation_p.K123N|TTC3_uc002ywb.2_Missense_Mutation_p.K123N|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Missense_Mutation_p.K123N	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	123					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TAAATTTGAAGAAACTACAAC	0.323													1	0	3.45872e-05	0.004007	3.53215e-05	15	62										T	38461129	G	T	38461129	3	4	88	1	0	0	0	0	1	0	0	0	16694	933	33	3	383	3	TTC3	21	38461129	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	719400	38461129	9668766	358	26556										
RIPK4	54101	broad.mit.edu	37	chr21	43161677	43161677	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcaggctcacgtccacgcctCggcgcagcaggatgcgcacg	14	16	1	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:43161677C>T	uc002yzn.1	-	8	1724	c.1676G>A	c.(1675-1677)CGA>CAA	p.R559Q		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	559						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GTCCACGCCTCGGCGCAGCAG	0.662													0	0	0	0.006214	0	10	95										T	43161677	C	T	43161677	3	4	88	1	0	0	0	0	1	0	0	0	13383	884	31	1	682	1	RIPK4	21	43161677	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	4700548	43161677	4968218	359	26557										
TRPM2	7226	broad.mit.edu	37	chr21	45837924	45837924	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccgccccccttcatcctcctCagccacctgcagctcttcat	4	22	4	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:45837924C>T	uc002zet.1	+	22	3474	c.3261C>T	c.(3259-3261)CTC>CTT	p.L1087L	TRPM2_uc002zeu.1_Silent_p.L1087L|TRPM2_uc002zew.1_Silent_p.L1087L|TRPM2_uc010gpt.1_Silent_p.L1087L|TRPM2_uc002zex.1_Silent_p.L873L|TRPM2_uc002zey.1_Silent_p.L600L|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1087	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCATCCTCCTCAGCCACCTGC	0.502													0	0	0	0.01892	0	22	234										T	45837924	C	T	45837924	2	4	88	1	0	0	0	0	0	0	0	1	16583	813	29	1		1	TRPM2	21	45837924	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	2676247	45837924	2291971	360	26558										
TRPM2	7226	broad.mit.edu	37	chr21	45837945	45837945	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agccacctgcagctcttcatCaagagggtggtcctgaagac	11	12	3	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:45837945C>G	uc002zet.1	+	22	3495	c.3282C>G	c.(3280-3282)ATC>ATG	p.I1094M	TRPM2_uc002zeu.1_Missense_Mutation_p.I1094M|TRPM2_uc002zew.1_Missense_Mutation_p.I1094M|TRPM2_uc010gpt.1_Missense_Mutation_p.I1094M|TRPM2_uc002zex.1_Missense_Mutation_p.I880M|TRPM2_uc002zey.1_Missense_Mutation_p.I607M|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1094	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGCTCTTCATCAAGAGGGTGG	0.512													0	0	0	0.024334	0	23	226										G	45837945	C	G	45837945	3	3	88	1	0	0	0	0	1	0	0	0	16583	816	29	1	3364	1	TRPM2	21	45837945	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	21	45837945	2291950	361	26559										
COL18A1	80781	broad.mit.edu	37	chr21	46911162	46911162	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gatccagggaaggacggagtCgggcagccgggcctccctgg	18	12	0	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr21:46911162C>T	uc011afs.1	+	21	3357	c.3336C>T	c.(3334-3336)GTC>GTT	p.V1112V	COL18A1_uc002zhg.2_Silent_p.V697V|COL18A1_uc002zhi.2_Silent_p.V877V	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1112	Triple-helical region 4 (COL4).			V -> L (in Ref. 5; AAA51864).	cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGACGGAGTCGGGCAGCCGG	0.682													0	0	0	0.001984	0	5	87										T	46911162	C	T	46911162	2	4	88	1	0	0	0	0	0	0	0	1	3675	871	31	1		1	COL18A1	21	46911162	Silent	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1073217	46911162	1218733	362	26560										
CHEK2	11200	broad.mit.edu	37	chr22	29091828	29091828	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggttctcatgagagaggtctCtcccaaaatcttggagtgcc	11	10	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29091828C>T	uc003adu.1	-	11	1201	c.1129G>A	c.(1129-1131)GAG>AAG	p.E377K	CHEK2_uc003ads.1_Missense_Mutation_p.E156K|CHEK2_uc010gvh.1_Missense_Mutation_p.E286K|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.E420K|CHEK2_uc003adv.1_Missense_Mutation_p.E348K|CHEK2_uc003adw.1_Missense_Mutation_p.E377K|CHEK2_uc003adx.1_Missense_Mutation_p.E156K|CHEK2_uc003ady.1_Missense_Mutation_p.E377K|CHEK2_uc003adz.1_Missense_Mutation_p.E181K	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	377	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AGAGAGGTCTCTCCCAAAATC	0.423			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.016522	0	22	74										T	29091828	C	T	29091828	3	4	88	1	0	0	0	0	1	0	0	0	3335	922	32	1	522	1	CHEK2	22	29091828	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08		29091828	22212738	363	26561			1	119		3	3	1142	N	G_C	9.658117e-05
CHEK2	11200	broad.mit.edu	37	chr22	29092917	29092917	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gacagtcctcttcttgagatGacagtaaaacattctctggc	8	10	3	2	rs121908703		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29092917G>T	uc003adu.1	-	10	1139	c.1067C>A	c.(1066-1068)TCA>TAA	p.S356*	CHEK2_uc003ads.1_Nonsense_Mutation_p.S135*|CHEK2_uc010gvh.1_Nonsense_Mutation_p.S265*|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Nonsense_Mutation_p.S399*|CHEK2_uc003adv.1_Intron|CHEK2_uc003adw.1_Nonsense_Mutation_p.S356*|CHEK2_uc003adx.1_Nonsense_Mutation_p.S135*|CHEK2_uc003ady.1_Nonsense_Mutation_p.S356*|CHEK2_uc003adz.1_Nonsense_Mutation_p.S160*	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	356	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TTCTTGAGATGACAGTAAAAC	0.378			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				1	0	1.36491e-13	0.016723	1.46545e-13	14	38										T	29092917	G	T	29092917	4	4	88	1	0	0	0	0	0	1	0	0	3335	1294	45	3	588	3	CHEK2	22	29092917	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1089	29092917	22211649	364	26562			1	119		3	3	1142	N	G_C	9.658117e-05
CHEK2	11200	broad.mit.edu	37	chr22	29092969	29092969	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtgtataataccgttttcatGaaggtactacacagaaaggc	9	7	1	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29092969G>A	uc003adu.1	-	10	1087	c.1015C>T	c.(1015-1017)CAT>TAT	p.H339Y	CHEK2_uc003ads.1_Missense_Mutation_p.H118Y|CHEK2_uc010gvh.1_Missense_Mutation_p.H248Y|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.H382Y|CHEK2_uc003adv.1_Intron|CHEK2_uc003adw.1_Missense_Mutation_p.H339Y|CHEK2_uc003adx.1_Missense_Mutation_p.H118Y|CHEK2_uc003ady.1_Missense_Mutation_p.H339Y|CHEK2_uc003adz.1_Missense_Mutation_p.H143Y	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	339	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCGTTTTCATGAAGGTACTAC	0.398			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.024245	0	12	33										A	29092969	G	A	29092969	3	1	88	1	0	0	0	0	1	0	0	0	3335	1290	45	1	640	1	CHEK2	22	29092969	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	52	29092969	22211597	365	26563			1	119		3	3	1142	N	G_C	9.658117e-05
THOC5	8563	broad.mit.edu	37	chr22	29940524	29940524	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agctcctggcaggtgtacttGtataactcatagtctctgcc	9	11	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:29940524G>C	uc003afr.2	-	4	500	c.165C>G	c.(163-165)TAC>TAG	p.Y55*	THOC5_uc003afs.2_Nonsense_Mutation_p.Y55*|THOC5_uc003aft.2_Nonsense_Mutation_p.Y55*|THOC5_uc003afu.2_Nonsense_Mutation_p.Y55*|THOC5_uc010gvo.2_5'UTR|THOC5_uc003afv.1_Nonsense_Mutation_p.Y55*|THOC5_uc003afw.1_5'Flank	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	55	Interaction with THOC7.|Interaction with CSF1R (By similarity).				intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						AGGTGTACTTGTATAACTCAT	0.542													0	0	0	0.027356	0	29	113										C	29940524	G	C	29940524	4	2	88	1	0	0	0	0	0	1	0	0	15865	1372	48	4	1958	4	THOC5	22	29940524	Nonsense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	847555	29940524	21364042	366	26564										
GAL3ST1	9514	broad.mit.edu	37	chr22	30951254	30951254	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gcgctcccgcccgaaggcctCcaccttgcgccagaagctgg	12	18	0	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:30951254C>G	uc003aig.1	-	4	1098	c.958G>C	c.(958-960)GAG>CAG	p.E320Q	GAL3ST1_uc003aih.1_Missense_Mutation_p.E320Q|GAL3ST1_uc003aii.1_Missense_Mutation_p.E320Q|GAL3ST1_uc010gvz.1_Missense_Mutation_p.E320Q	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	320	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						CCGAAGGCCTCCACCTTGCGC	0.711													0	0	0	0.00308	0	8	13										G	30951254	C	G	30951254	3	3	88	1	0	0	0	0	1	0	0	0	6197	864	30	1	317	1	GAL3ST1	22	30951254	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	1010730	30951254	20353312	367	26565										
MYH9	4627	broad.mit.edu	37	chr22	36695011	36695011	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgcttgttcttgagcttggcGaggctcttagatttctcctc	10	10	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:36695011G>A	uc003apg.2	-	24	3285	c.3054C>T	c.(3052-3054)CTC>CTT	p.L1018L		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1018	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGAGCTTGGCGAGGCTCTTAG	0.562			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.012319	0	22	57										A	36695011	G	A	36695011	2	1	88	1	0	0	0	0	0	0	0	1	10042	1045	37	1		1	MYH9	22	36695011	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	5743757	36695011	14609555	368	26566										
MFNG	4242	broad.mit.edu	37	chr22	37868558	37868558	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccctcaaagacaccgtagctGagggtgacctgggcagggag	15	11	1	3	rs11548403		TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chr22:37868558G>A	uc003ass.1	-	7	992	c.822C>T	c.(820-822)CTC>CTT	p.L274L	MFNG_uc011ani.1_Silent_p.L152L|MFNG_uc011anj.1_Silent_p.L260L|MFNG_uc003asr.1_RNA	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	274	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)					CACCGTAGCTGAGGGTGACCT	0.602											OREG0026538	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	119										A	37868558	G	A	37868558	2	1	88	1	0	0	0	0	0	0	0	1	9525	1277	45	1		1	MFNG	22	37868558	Silent	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08	1173547	37868558	13436008	369	26567										
MXRA5	25878	broad.mit.edu	37	chrX	3238916	3238916	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ggcagggactctggttagttGatgagaagcatgaactcttc	13	7	2	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:3238916G>C	uc004crg.3	-	5	4967	c.4810C>G	c.(4810-4812)CAA>GAA	p.Q1604E		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1604						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGGTTAGTTGATGAGAAGCA	0.483													0	0	0	0.025465	0	42	82										C	3238916	G	C	3238916	3	2	88	1	0	0	0	0	1	0	0	0	10003	1299	45	1	3688	1	MXRA5	23	3238916	Missense_Mutation	SNP	G	TCGA-FJ-A3Z7-01A-12D-A23M-08		3238916	152031644	370	26568										
OFD1	8481	broad.mit.edu	37	chrX	13780470	13780470	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ccttccaatctagtctttatCgaagacaaactgaacttcaa	4	11	3	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:13780470C>G	uc004cvp.3	+	18	2754	c.2395C>G	c.(2395-2397)CGA>GGA	p.R799G	OFD1_uc004cvr.3_Missense_Mutation_p.R366G|OFD1_uc011mil.1_Missense_Mutation_p.R366G|OFD1_uc004cvq.3_Missense_Mutation_p.R659G|OFD1_uc010nen.2_Missense_Mutation_p.R798G|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.R758G|OFD1_uc004cvv.3_Missense_Mutation_p.R758G	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	799	Mediates the interaction with SDCCAG8.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						TAGTCTTTATCGAAGACAAAC	0.343													0	0	0	0.027356	0	24	64										G	13780470	C	G	13780470	3	3	88	1	0	0	0	0	1	0	0	0	10838	876	31	1	2465	1	OFD1	23	13780470	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	10541554	13780470	141490090	371	26569										
FAM47B	170062	broad.mit.edu	37	chrX	34961687	34961687	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	cagagactcgcgcatctcatCtccgcgtggatcctcccgag	10	16	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:34961687C>G	uc004ddi.1	+	1	757	c.739C>G	c.(739-741)CTC>GTC	p.L247V		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	247	Pro-rich.									ovary(3)|breast(1)	4						CGCATCTCATCTCCGCGTGGA	0.627													0	0	0	0.024334	0	25	63										G	34961687	C	G	34961687	3	3	88	1	0	0	0	0	1	0	0	0	5570	913	32	1	741	1	FAM47B	23	34961687	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	21181217	34961687	120308873	372	26570										
CDK16	5127	broad.mit.edu	37	chrX	47083838	47083838	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tggggagagtgaccaggcttCagccacgtcctcggatgagg	16	10	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:47083838C>T	uc004dho.2	+	3	653	c.257C>T	c.(256-258)TCA>TTA	p.S86L	CDK16_uc011mli.1_Missense_Mutation_p.S92L|CDK16_uc011mlj.1_Missense_Mutation_p.S86L|CDK16_uc011mlk.1_Missense_Mutation_p.S86L|CDK16_uc011mll.1_Missense_Mutation_p.S160L	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	86							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						GACCAGGCTTCAGCCACGTCC	0.607													0	0	0	0.020292	0	15	23										T	47083838	C	T	47083838	3	4	88	1	0	0	0	0	1	0	0	0	3132	838	29	1	505	1	CDK16	23	47083838	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	12122151	47083838	108186722	373	26571										
ARHGEF9	23229	broad.mit.edu	37	chrX	62885870	62885870	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	ctccccagtgtagatcagctCcgagctcctgtctaggatgt	10	13	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:62885870C>G	uc004dvl.2	-	7	1791	c.952G>C	c.(952-954)GAG>CAG	p.E318Q	ARHGEF9_uc004dvj.1_Missense_Mutation_p.E207Q|ARHGEF9_uc004dvk.1_Intron|ARHGEF9_uc011mos.1_Missense_Mutation_p.E297Q|ARHGEF9_uc004dvm.1_Missense_Mutation_p.E297Q|ARHGEF9_uc011mot.1_Missense_Mutation_p.E265Q|ARHGEF9_uc004dvn.2_Missense_Mutation_p.E325Q	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	318	PH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						TAGATCAGCTCCGAGCTCCTG	0.592													0	0	0	0.004007	0	16	31										G	62885870	C	G	62885870	3	3	88	1	0	0	0	0	1	0	0	0	912	864	30	1	614	1	ARHGEF9	23	62885870	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	15802032	62885870	92384690	374	26572										
FAM123B	139285	broad.mit.edu	37	chrX	63411969	63411969	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	taagtcatcatcttcttcctCctccttaacctcctcttctt	1	16	6	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:63411969C>A	uc004dvo.2	-	2	1471	c.1198G>T	c.(1198-1200)GAG>TAG	p.E400*		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	400	Glu-rich.				Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						tcttcttcctcctccttaacc	0.343													1	0	2.35188e-11	0.006122	2.49175e-11	18	42										A	63411969	C	A	63411969	4	1	88	1	0	0	0	0	0	1	0	0	5423	864	30	3	2213	3	FAM123B	23	63411969	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	526099	63411969	91858591	375	26573			2	120		3	3	607	C		2.734165e-05
FAM123B	139285	broad.mit.edu	37	chrX	63412290	63412290	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	gtttacctctcctgctactaCcttctcccctgtttctgggc	6	16	3	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:63412290C>T	uc004dvo.2	-	2	1150	c.877G>A	c.(877-879)GTA>ATA	p.V293I		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	293					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CCTGCTACTACCTTCTCCCCT	0.557													0	0	0	0.011902	0	46	103										T	63412290	C	T	63412290	3	4	88	1	0	0	0	0	1	0	0	0	5423	507	18	2	2534	2	FAM123B	23	63412290	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	321	63412290	91858270	376	26574			2	120		3	3	607	C		2.734165e-05
FAM123B	139285	broad.mit.edu	37	chrX	63412575	63412575	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	aggcctggctctgaccctctCaggccccttggcccctggct	11	18	2	1			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:63412575C>G	uc004dvo.2	-	2	865	c.592G>C	c.(592-594)GAG>CAG	p.E198Q		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	198					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTGACCCTCTCAGGCCCCTTG	0.577													0	0	0	0.004007	0	16	35										G	63412575	C	G	63412575	3	3	88	1	0	0	0	0	1	0	0	0	5423	835	29	1	2819	1	FAM123B	23	63412575	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	285	63412575	91857985	377	26575			2	120		3	3	607	C		2.734165e-05
MAGEE1	57692	broad.mit.edu	37	chrX	75649248	75649248	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	agggcctgagcacctccgtgCagcccactgctggtgaggga	15	13	0	2			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:75649248C>T	uc004ecm.1	+	1	1132	c.925C>T	c.(925-927)CAG>TAG	p.Q309*		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	309	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CACCTCCGTGCAGCCCACTGC	0.692													0	0	0	0.004672	0	3	22										T	75649248	C	T	75649248	4	4	88	1	0	0	0	0	0	1	0	0	9185	711	25	2	927	2	MAGEE1	23	75649248	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	12236673	75649248	79621312	378	26576										
DIAPH2	1730	broad.mit.edu	37	chrX	96854279	96854279	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	acgagtacctttggaaaggtCacgctctcgccacaatggag	11	11	2	0			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:96854279C>G	uc004efu.3	+	27	3665	c.3269C>G	c.(3268-3270)TCA>TGA	p.S1090*		NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	1090					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						TTGGAAAGGTCACGCTCTCGC	0.353													0	0	0	0.00308	0	7	3										G	96854279	C	G	96854279	4	3	88	1	0	0	0	0	0	1	0	0	4519	838	29	1	3429	1	DIAPH2	23	96854279	Nonsense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	21205031	96854279	58416281	379	26577										
AVPR2	554	broad.mit.edu	37	chrX	153171751	153171751	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448548812664908	170	1.92429987628997e-54	3.63900853311662	4.40908695652174	3.17926022063595	0.11316228856724	0.233509484345098	123	tgagggagcccacgtgtcagCagctgtggccaagactgtga	15	10	1	3			TCGA-FJ-A3Z7-01A-12D-A23M-08	TCGA-FJ-A3Z7-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	298ad91c-8d67-4240-9937-85e5769d460f	0eb62be9-ac9f-4a73-9453-6a5c109c19c1	g.chrX:153171751C>T	uc004fjh.3	+	2	862	c.791C>T	c.(790-792)GCA>GTA	p.A264V	AVPR2_uc004fjg.3_Missense_Mutation_p.A53V|AVPR2_uc004fji.2_Missense_Mutation_p.A264V	NM_000054	NP_000045	P30518	V2R_HUMAN	arginine vasopressin receptor 2 isoform 1	264	Cytoplasmic (Potential).				activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	CACGTGTCAGCAGCTGTGGCC	0.657													0	0	0	0.007413	0	19	18										T	153171751	C	T	153171751	3	4	88	1	0	0	0	0	1	0	0	0	1233	710	25	2	797	2	AVPR2	23	153171751	Missense_Mutation	SNP	C	TCGA-FJ-A3Z7-01A-12D-A23M-08	56317472	153171751	2098809	380	26578										
CPSF3L	54973	broad.mit.edu	37	chr1	1248252	1248252	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acgctctccggctctgcctgGcccaccagctgcatgatgcc	10	18	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:1248252G>A	uc001aee.1	-	12	1267	c.1209C>T	c.(1207-1209)GGC>GGT	p.G403G	CPSF3L_uc009vjy.1_RNA|CPSF3L_uc001aef.1_Silent_p.G409G|CPSF3L_uc009vjz.1_Silent_p.G381G|CPSF3L_uc010nyj.1_Silent_p.G374G|CPSF3L_uc001aeg.1_Silent_p.G279G|CPSF3L_uc001aeh.1_Silent_p.G302G|CPSF3L_uc001aei.1_Silent_p.G305G|CPSF3L_uc001aej.1_Silent_p.G230G|CPSF3L_uc001aek.1_Silent_p.G145G	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	403						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		GCTCTGCCTGGCCCACCAGCT	0.632													0	0	0	0.01441	0	59	5										A	1248252	G	A	1248252	2	1	89	1	0	0	0	0	0	0	0	1	3827	1190	42	2		2	CPSF3L	1	1248252	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		1248252	248002369	1	26579										
KIAA0562	9731	broad.mit.edu	37	chr1	3742336	3742336	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cctgacctgtttgcagtggtCacatcttgtcagcatgagac	10	11	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:3742336C>A	uc001aky.2	-	18	2709	c.2350G>T	c.(2350-2352)GAC>TAC	p.D784Y	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	784						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TTGCAGTGGTCACATCTTGTC	0.507													1	0	1.61004e-24	0.01441	2.02165e-24	45	32										A	3742336	C	A	3742336	3	1	89	1	0	0	0	0	1	0	0	0	8184	826	29	3	447	3	KIAA0562	1	3742336	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2494084	3742336	245508285	2	26580										
MFN2	9927	broad.mit.edu	37	chr1	12057360	12057360	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcctctgccatcagactgtgAaccagctggcccatgccctc	8	17	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:12057360A>G	uc001atn.3	+	6	934	c.481A>G	c.(481-483)AAC>GAC	p.N161D	MFN2_uc009vni.2_Missense_Mutation_p.N161D	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	161	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCAGACTGTGAACCAGCTGGC	0.572													0	0	0	0.01441	0	50	4										G	12057360	A	G	12057360	3	3	89	1	0	0	0	0	1	0	0	0	9524	246	9	5	495	5	MFN2	1	12057360	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	8315024	12057360	237193261	3	26581										
TNFRSF1B	7133	broad.mit.edu	37	chr1	12251959	12251959	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgctgcgcaagtgccgcccgGgcttcggcgtggccagacca	15	16	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:12251959G>T	uc001att.2	+	4	525	c.436G>T	c.(436-438)GGC>TGC	p.G146C	TNFRSF1B_uc001atu.2_5'UTR|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	146	TNFR-Cys 3.|Extracellular (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GTGCCGCCCGGGCTTCGGCGT	0.682													1	0	6.75472e-32	0.01441	9.01171e-32	58	5										T	12251959	G	T	12251959	3	4	89	1	0	0	0	0	1	0	0	0	16291	1232	43	4	450	4	TNFRSF1B	1	12251959	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	194599	12251959	236998662	4	26582										
UBR4	23352	broad.mit.edu	37	chr1	19404471	19404471	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cctctgacagcctccttaccTtaaacatgttgtaaatgaga	6	11	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:19404471T>G	uc001bbi.2	-	104	15327	c.15323A>C	c.(15322-15324)AAG>ACG	p.K5108T	UBR4_uc001bbe.1_5'Flank|UBR4_uc001bbf.2_Missense_Mutation_p.K3T|UBR4_uc010ocv.1_Missense_Mutation_p.K631T|UBR4_uc009vph.2_Missense_Mutation_p.K742T|UBR4_uc010ocw.1_Missense_Mutation_p.K772T|UBR4_uc001bbg.2_Missense_Mutation_p.K819T|UBR4_uc001bbh.2_Missense_Mutation_p.K817T	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	5108					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCTCCTTACCTTAAACATGTT	0.507													0	0	0	0.01441	0	43	2										G	19404471	T	G	19404471	3	3	89	1	0	0	0	0	1	0	0	0	16901	1623	56	5	240	5	UBR4	1	19404471	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	7152512	19404471	229846150	5	26583										
FAM43B	163933	broad.mit.edu	37	chr1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcagcatccaggaggaggacGaggaggaggaggaggacgac							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:20880268_20880270delGAG	uc001bdj.2	+	1	1337_1339	c.802_804delGAG	c.(802-804)GAGdel	p.E272del		NM_207334	NP_997217	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272											0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.567																		2	4	---	---								-	20880270	GAG	-	20880268	7	5	89	1	0	1	0	1	0	0	0	0	5563	1059	37	0	804	0	FAM43B	1	20880268	In_Frame_Del	DEL	GAG	TCGA-FJ-A3ZE-01A-11D-A23M-08	1475797	20880268	228370353	6	26584										
PTPRU	10076	broad.mit.edu	37	chr1	29638200	29638200	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggactcagacacctacgggGacatcaagattatgctggtg	12	9	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:29638200G>C	uc001bru.2	+	22	3141	c.3031G>C	c.(3031-3033)GAC>CAC	p.D1011H	PTPRU_uc001brv.2_Missense_Mutation_p.D1007H|PTPRU_uc001brw.2_Missense_Mutation_p.D1001H|PTPRU_uc009vtq.2_Missense_Mutation_p.D1007H|PTPRU_uc009vtr.2_Missense_Mutation_p.D998H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1011	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CACCTACGGGGACATCAAGAT	0.607													0	0	0	0.013114	0	45	88										C	29638200	G	C	29638200	3	2	89	1	0	0	0	0	1	0	0	0	12813	1174	41	1	3139	1	PTPRU	1	29638200	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8757932	29638200	219612421	7	26585										
UROD	7389	broad.mit.edu	37	chr1	45480182	45480182	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aacaagtttgcactgccttaCatccgtgatgtggccaagca	9	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:45480182C>T	uc001cna.1	+	7	816	c.708C>T	c.(706-708)TAC>TAT	p.Y236Y	UROD_uc001cnb.1_Silent_p.Y201Y|UROD_uc010olj.1_3'UTR|UROD_uc001cnc.1_Silent_p.Y141Y	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	236						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					CACTGCCTTACATCCGTGATG	0.542									Porphyria_Cutanea_Tarda_Type_II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	67	3										T	45480182	C	T	45480182	2	4	89	1	0	0	0	0	0	0	0	1	17026	489	17	2		2	UROD	1	45480182	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	15841982	45480182	203770439	8	26586										
USP24	23358	broad.mit.edu	37	chr1	55549036	55549036	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatctccagccctaattcctTgctgtcacaagatattgaga	7	11	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:55549036T>G	uc001cyg.3	-	55	6404	c.6404A>C	c.(6403-6405)CAA>CCA	p.Q2135P		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	2295					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						CCTAATTCCTTGCTGTCACAA	0.393													0	0	0	0.021523	0	26	6										G	55549036	T	G	55549036	3	3	89	1	0	0	0	0	1	0	0	0	17052	1826	63	5	1022	5	USP24	1	55549036	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	10068854	55549036	193701585	9	26587										
INADL	10207	broad.mit.edu	37	chr1	62240939	62240939	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggctctggactaggttttgGaatagttggaggaaaaacaa	13	4	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:62240939G>T	uc001dab.2	+	7	896	c.782G>T	c.(781-783)GGA>GTA	p.G261V	INADL_uc009waf.1_Missense_Mutation_p.G261V|INADL_uc001daa.2_Missense_Mutation_p.G261V|INADL_uc001dad.3_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	261	PDZ 2.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CTAGGTTTTGGAATAGTTGGA	0.413													1	0	6.70656e-16	0.01441	7.80323e-16	61	96										T	62240939	G	T	62240939	3	4	89	1	0	0	0	0	1	0	0	0	7731	1174	41	3	804	3	INADL	1	62240939	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	6691903	62240939	187009682	10	26588										
KANK4	163782	broad.mit.edu	37	chr1	62739459	62739459	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccccagctttcagactccatGctgcctagaaggttgacttc	8	14	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:62739459G>A	uc001dah.3	-	3	1694	c.1317C>T	c.(1315-1317)AGC>AGT	p.S439S	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	439										ovary(3)|skin(2)|lung(1)	6						CAGACTCCATGCTGCCTAGAA	0.562													0	0	0	0.01441	0	116	105										A	62739459	G	A	62739459	2	1	89	1	0	0	0	0	0	0	0	1	7979	1310	46	2		2	KANK4	1	62739459	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	498520	62739459	186511162	11	26589										
SGIP1	84251	broad.mit.edu	37	chr1	67147961	67147961	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gattttgggttgggacaaagAgcaactccacctcccccacc	9	14	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:67147961A>T	uc001dcr.2	+	15	1441	c.1224A>T	c.(1222-1224)AGA>AGT	p.R408S	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.R175S	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	408	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TGGGACAAAGAGCAACTCCAC	0.512													0	0	0	0.004656	0	26	179										T	67147961	A	T	67147961	3	4	89	1	0	0	0	0	1	0	0	0	14206	301	11	5	1282	5	SGIP1	1	67147961	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	4408502	67147961	182102660	12	26590										
MIER1	57708	broad.mit.edu	37	chr1	67436628	67436628	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcctgaaggatctcacataAaagacaatgaacaggtctgt	8	8	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:67436628A>G	uc001dde.2	+	9	1044	c.910A>G	c.(910-912)AAA>GAA	p.K304E	MIER1_uc010opf.1_Missense_Mutation_p.K268E|MIER1_uc009way.2_Missense_Mutation_p.K268E|MIER1_uc001ddc.2_Missense_Mutation_p.K304E|MIER1_uc001ddh.2_Missense_Mutation_p.K188E|MIER1_uc001ddf.2_Missense_Mutation_p.K268E|MIER1_uc001ddg.2_Missense_Mutation_p.K224E|MIER1_uc010opg.1_Missense_Mutation_p.K268E|MIER1_uc001ddj.1_Missense_Mutation_p.K251E|MIER1_uc001ddi.2_Missense_Mutation_p.K251E	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	275	ELM2.|Interaction with HDAC1.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						ATCTCACATAAAAGACAATGA	0.353													0	0	0	0.01892	0	19	42										G	67436628	A	G	67436628	3	3	89	1	0	0	0	0	1	0	0	0	9580	15	1	5	1021	5	MIER1	1	67436628	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	288667	67436628	181813993	13	26591										
FPGT	8790	broad.mit.edu	37	chr1	74670542	74670542	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actctgactatgtctacacaGatagcctattttatatggat	6	8	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:74670542G>C	uc001dgb.1	+	4	848	c.811G>C	c.(811-813)GAT>CAT	p.D271H	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	271					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TGTCTACACAGATAGCCTATT	0.368													0	0	0	0.021523	0	25	21										C	74670542	G	C	74670542	3	2	89	1	0	0	0	0	1	0	0	0	6037	942	33	1	825	1	FPGT	1	74670542	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7233914	74670542	174580079	14	26592										
BARHL2	343472	broad.mit.edu	37	chr1	91178154	91178154	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcggccagcaactccaggccCaccgctgtctgccgcttcca	9	19	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:91178154C>A	uc001dns.2	-	3	921	c.879G>T	c.(877-879)GTG>GTT	p.V293V		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	293						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		ACTCCAGGCCCACCGCTGTCT	0.617													1	0	9.16793e-09	0.00499	9.76622e-09	17	19										A	91178154	C	A	91178154	2	1	89	1	0	0	0	0	0	0	0	1	1314	581	21	4		4	BARHL2	1	91178154	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	16507612	91178154	158072467	15	26593										
CCDC18	343099	broad.mit.edu	37	chr1	93667528	93667528	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aacaatataaaaaaaaagtgGctgaaaaactggaaaaggta	8	3	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:93667528G>A	uc001dpq.2	+	7	1300	c.1132G>A	c.(1132-1134)GCT>ACT	p.A378T		NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	260	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAAAAAAGTGGCTGAAAAACT	0.308													0	0	0	0.00499	0	17	17										A	93667528	G	A	93667528	3	1	89	1	0	0	0	0	1	0	0	0	2794	1203	42	2	1158	2	CCDC18	1	93667528	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2489374	93667528	155583093	16	26594										
ANKRD35	148741	broad.mit.edu	37	chr1	145561389	145561389	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agagcttcaggaaagcaaggCtctagtctccggcctggagg	14	10	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:145561389C>T	uc001eob.1	+	10	1185	c.1077C>T	c.(1075-1077)GGC>GGT	p.G359G	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Silent_p.G202G	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	359										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAAAGCAAGGCTCTAGTCTCC	0.582													0	0	0	0.010504	0	22	30										T	145561389	C	T	145561389	2	4	89	1	0	0	0	0	0	0	0	1	664	784	28	2		2	ANKRD35	1	145561389	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	51893861	145561389	103689232	17	26595										
HIST2H3D	653604	broad.mit.edu	37	chr1	149785176	149785176	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcgggccgctttggtagccaGctgcttcctcggggccttgc	15	14	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:149785176G>A	uc010pbl.1	-	1	61	c.61C>T	c.(61-63)CTG>TTG	p.L21L	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	21					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						TTGGTAGCCAGCTGCTTCCTC	0.667													0	0	0	0.012213	0	21	75										A	149785176	G	A	149785176	2	1	89	1	0	0	0	0	0	0	0	1	7181	962	34	2		2	HIST2H3D	1	149785176	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4223787	149785176	99465445	18	26596										
SNX27	81609	broad.mit.edu	37	chr1	151611551	151611551	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcaagcagtgcccatatcgGtccccagatacaaacatgtg	9	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:151611551G>A	uc001eyn.1	+	2	515	c.499G>A	c.(499-501)GTC>ATC	p.V167I	SNX27_uc001eyo.2_Missense_Mutation_p.V74I|SNX27_uc001eyp.2_5'UTR	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	167	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCCATATCGGTCCCCAGATA	0.463													0	0	0	0.01441	0	49	73										A	151611551	G	A	151611551	3	1	89	1	0	0	0	0	1	0	0	0	14897	1261	44	2	505	2	SNX27	1	151611551	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1826375	151611551	97639070	19	26597										
EFNA1	1942	broad.mit.edu	37	chr1	155104034	155104034	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagcatggcccggagaagctGtctgagaagttccagcgctt	13	10	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:155104034G>A	uc001fhh.2	+	2	417	c.312G>A	c.(310-312)CTG>CTA	p.L104L	EFNA1_uc001fhi.2_Silent_p.L104L|EFNA1_uc009wpd.1_5'Flank	NM_004428	NP_004419	P20827	EFNA1_HUMAN	ephrin A1 isoform a precursor	104					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGGAGAAGCTGTCTGAGAAGT	0.582													0	0	0	0.012319	0	22	41										A	155104034	G	A	155104034	2	1	89	1	0	0	0	0	0	0	0	1	4950	1364	48	2		2	EFNA1	1	155104034	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3492483	155104034	94146587	20	26598										
CCT3	7203	broad.mit.edu	37	chr1	156294831	156294831	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcactgatcaccactgttggGtgcatctgctgctccaggaa	11	12	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:156294831G>C	uc001fol.1	-	6	574	c.354C>G	c.(352-354)CAC>CAG	p.H118Q	CCT3_uc001fom.1_Missense_Mutation_p.H117Q|CCT3_uc001fon.1_Missense_Mutation_p.H80Q|CCT3_uc010phj.1_Missense_Mutation_p.H72Q|CCT3_uc010phk.1_Missense_Mutation_p.H72Q|CCT3_uc010phl.1_Missense_Mutation_p.H72Q	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	118					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCACTGTTGGGTGCATCTGCT	0.433													0	0	0	0.021022	0	37	90										C	156294831	G	C	156294831	3	2	89	1	0	0	0	0	1	0	0	0	2954	1252	44	4	1319	4	CCT3	1	156294831	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1190797	156294831	92955790	21	26599										
FCRL4	83417	broad.mit.edu	37	chr1	157557731	157557731	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccaatgcatcgataattgccAttgttatttgaacttgcttg	7	8	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:157557731A>G	uc001fqw.2	-	4	622	c.486T>C	c.(484-486)AAT>AAC	p.N162N	FCRL4_uc010phy.1_Intron	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	162	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GATAATTGCCATTGTTATTTG	0.308													0	0	0	0.016723	0	13	14										G	157557731	A	G	157557731	2	3	89	1	0	0	0	0	0	0	0	1	5797	214	8	5		5	FCRL4	1	157557731	Silent	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1262900	157557731	91692890	22	26600										
SPTA1	6708	broad.mit.edu	37	chr1	158590242	158590242	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gccttatgtgcaaattccacGaacaggtcctcagcctgcag	9	13	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:158590242G>A	uc001fst.1	-	44	6334	c.6135C>T	c.(6133-6135)TTC>TTT	p.F2045F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2045	Spectrin 20.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAAATTCCACGAACAGGTCCT	0.368													0	0	0	0.007413	0	19	50										A	158590242	G	A	158590242	2	1	89	1	0	0	0	0	0	0	0	1	15115	1049	37	1		1	SPTA1	1	158590242	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1032511	158590242	90660379	23	26601										
SPTA1	6708	broad.mit.edu	37	chr1	158641934	158641934	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actgctcatactgacgatgaCgctcgtcccacagttccagc	8	15	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:158641934C>A	uc001fst.1	-	11	1602	c.1403G>T	c.(1402-1404)CGT>CTT	p.R468L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	468	Spectrin 5.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTGACGATGACGCTCGTCCCA	0.438													1	0	7.73544e-29	0.01441	1.01254e-28	64	52										A	158641934	C	A	158641934	3	1	89	1	0	0	0	0	1	0	0	0	15115	536	19	4	6024	4	SPTA1	1	158641934	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	51692	158641934	90608687	24	26602										
SLAMF8	56833	broad.mit.edu	37	chr1	159802972	159802972	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tagctgtcatcatgaggcagGtatgctaagggccagcagtc	13	9	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:159802972G>A	uc001fue.3	+	3	883	c.673_splice	c.e3+1	p.A225_splice		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor							integral to membrane					0	all_hematologic(112;0.0597)					CATGAGGCAGGTATGCTAAGG	0.562													0	0	0	0.01441	0	105	62										A	159802972	G	A	159802972	5	1	89	1	0	0	0	0	0	0	1	0	14370	1275	44	2	684	2	SLAMF8	1	159802972	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1161038	159802972	89447649	25	26603										
DCAF8	50717	broad.mit.edu	37	chr1	160209813	160209813	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccagtcctctagggcccgctCatcatctgatgagtcctggt	10	14	4	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:160209813C>A	uc001fvo.2	-	4	709	c.397G>T	c.(397-399)GAG>TAG	p.E133*	DCAF8_uc001fvn.2_Nonsense_Mutation_p.E133*|DCAF8_uc009wth.2_Nonsense_Mutation_p.E133*|DCAF8_uc010pjb.1_Nonsense_Mutation_p.E133*|DCAF8_uc010pjc.1_Nonsense_Mutation_p.E287*|DCAF8_uc001fvq.3_Nonsense_Mutation_p.E133*|DCAF8_uc001fvp.3_Nonsense_Mutation_p.E133*|uc010pjd.1_3'UTR	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	133						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						AGGGCCCGCTCATCATCTGAT	0.512													1	0	3.21987e-24	0.01441	4.03392e-24	46	80										A	160209813	C	A	160209813	4	1	89	1	0	0	0	0	0	1	0	0	4276	835	29	3	1440	3	DCAF8	1	160209813	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	406841	160209813	89040808	26	26604										
UCK2	7371	broad.mit.edu	37	chr1	165860506	165860506	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcaaaacactcaaagaaatCactgaagggaaaacagtcca	6	10	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:165860506C>T	uc001gdp.2	+	3	484	c.303C>T	c.(301-303)ATC>ATT	p.I101I	UCK2_uc010plb.1_Missense_Mutation_p.S11L	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	101					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCAAAGAAATCACTGAAGGGA	0.413													0	0	0	0.005524	0	37	94										T	165860506	C	T	165860506	2	4	89	1	0	0	0	0	0	0	0	1	16921	816	29	1		1	UCK2	1	165860506	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5650693	165860506	83390115	27	26605										
DUSP27	92235	broad.mit.edu	37	chr1	167096802	167096802	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgagctcacccgcggaaagtTgcagaagcaaagtgaggggg	16	8	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:167096802T>G	uc001geb.1	+	5	2434	c.2434T>G	c.(2434-2436)TGC>GGC	p.C812G		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	812					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CGCGGAAAGTTGCAGAAGCAA	0.562													0	0	0	0.01441	0	88	51										G	167096802	T	G	167096802	3	3	89	1	0	0	0	0	1	0	0	0	4824	1812	63	5	2452	5	DUSP27	1	167096802	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1236296	167096802	82153819	28	26606										
RCSD1	92241	broad.mit.edu	37	chr1	167653169	167653169	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagaccaatgccaatgtggaCaactcggcgtccccctcggt	11	14	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:167653169C>A	uc001gem.2	+	2	226	c.39C>A	c.(37-39)GAC>GAA	p.D13E	RCSD1_uc010pli.1_Missense_Mutation_p.D13E	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	13										ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					CCAATGTGGACAACTCGGCGT	0.587													1	0	2.4537e-52	0.01441	3.45635e-52	120	313										A	167653169	C	A	167653169	3	1	89	1	0	0	0	0	1	0	0	0	13185	477	17	4	45	4	RCSD1	1	167653169	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	556367	167653169	81597452	29	26607										
ASTN1	460	broad.mit.edu	37	chr1	176863873	176863873	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctccagccgccatgtgcttgGtgccggagtctgacaagctg	13	13	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:176863873G>A	uc001glc.2	-	17	2977	c.2765C>T	c.(2764-2766)ACC>ATC	p.T922I	ASTN1_uc001glb.1_Missense_Mutation_p.T922I|ASTN1_uc001gld.1_Missense_Mutation_p.T922I	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	930					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CATGTGCTTGGTGCCGGAGTC	0.597													0	0	0	0.01441	0	36	142										A	176863873	G	A	176863873	3	1	89	1	0	0	0	0	1	0	0	0	1064	1261	44	2	1151	2	ASTN1	1	176863873	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	9210704	176863873	72386748	30	26608										
C1orf49	84066	broad.mit.edu	37	chr1	178483197	178483197	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcagtttgcctggaattgaaGccagagccgaccaaagtaag	12	9	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:178483197G>A	uc001glt.1	+	2	187	c.75G>A	c.(73-75)AAG>AAA	p.K25K	C1orf49_uc001glu.1_Silent_p.K25K|C1orf49_uc001glv.1_RNA|C1orf49_uc001glw.1_Silent_p.K33K	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	25						microtubule cytoskeleton					0						TGGAATTGAAGCCAGAGCCGA	0.507													0	0	0	0.015359	0	35	78										A	178483197	G	A	178483197	2	1	89	1	0	0	0	0	0	0	0	1	2041	962	34	2		2	C1orf49	1	178483197	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1619324	178483197	70767424	31	26609										
QSOX1	5768	broad.mit.edu	37	chr1	180165664	180165664	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagccggaattcaactctggAccctgggaagcctgagatga	12	10	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:180165664A>G	uc001gnz.2	+	12	1811	c.1736A>G	c.(1735-1737)GAC>GGC	p.D579G	QSOX1_uc001gny.2_Missense_Mutation_p.D579G|QSOX1_uc001goa.2_Missense_Mutation_p.D579G|QSOX1_uc001goc.2_Missense_Mutation_p.D121G|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	579					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						TCAACTCTGGACCCTGGGAAG	0.642													0	0	0	0.01441	0	74	143										G	180165664	A	G	180165664	3	3	89	1	0	0	0	0	1	0	0	0	12883	275	10	5	1782	5	QSOX1	1	180165664	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1682467	180165664	69084957	32	26610										
GLT25D2	23127	broad.mit.edu	37	chr1	183933111	183933111	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggggcttcagggggatgggCaggtagccatagtgctctct	17	8	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:183933111C>A	uc001gqr.2	-	6	1248	c.876G>T	c.(874-876)CTG>CTT	p.L292L	GLT25D2_uc010poj.1_Silent_p.L292L|GLT25D2_uc001gqq.2_Silent_p.L29L|GLT25D2_uc001gqs.2_Silent_p.L172L	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	292					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						GGGGGATGGGCAGGTAGCCAT	0.522													1	0	4.7796e-09	0.004656	5.11114e-09	24	59										A	183933111	C	A	183933111	2	1	89	1	0	0	0	0	0	0	0	1	6467	697	25	4		4	GLT25D2	1	183933111	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3767447	183933111	65317510	33	26611										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185278644	185278644	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atttttccttataaatttggCtagatgatgaaaagaaagct	7	4	0	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:185278644C>A	uc001grl.2	-	3	606	c.-17_splice	c.e3-1		IVNS1ABP_uc009wyj.2_Splice_Site|IVNS1ABP_uc009wyk.2_Splice_Site	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein						interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ATAAATTTGGCTAGATGATGA	0.299													1	0	1.40151e-16	0.010504	1.64796e-16	22	39										A	185278644	C	A	185278644	5	1	89	1	0	0	0	0	0	0	1	0	7930	811	28	4		4	IVNS1ABP	1	185278644	Splice_Site	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1345533	185278644	63971977	34	26612										
PTPRC	5788	broad.mit.edu	37	chr1	198713182	198713182	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatttgttcttgaaattgtaGgcccagtacatcttgatcca	7	8	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:198713182G>T	uc001gur.1	+	26	2872	c.2692_splice	c.e26-1	p.A898_splice	PTPRC_uc001gus.1_Splice_Site_p.A850_splice|PTPRC_uc001gut.1_Splice_Site_p.A737_splice	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C						axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGAAATTGTAGGCCCAGTACA	0.328													1	0	3.76114e-14	0.019004	4.29512e-14	32	24										T	198713182	G	T	198713182	5	4	89	1	0	0	0	0	0	0	1	0	12797	1014	35	4	2800	4	PTPRC	1	198713182	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	13434538	198713182	50537439	35	26613										
CACNA1S	779	broad.mit.edu	37	chr1	201016656	201016656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccaaagtagcacctacctcCtattggagggatgacctggt	10	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:201016656C>T	uc001gvv.2	-	37	4767	c.4540G>A	c.(4540-4542)GGA>AGA	p.G1514R		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1514	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CACCTACCTCCTATTGGAGGG	0.547													0	0	0	0.007413	0	18	46										T	201016656	C	T	201016656	3	4	89	1	0	0	0	0	1	0	0	0	2547	690	24	2	1113	2	CACNA1S	1	201016656	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2303474	201016656	48233965	36	26614										
LMOD1	25802	broad.mit.edu	37	chr1	201868633	201868633	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttggggagcccttagccacgGccccggccttgggtacctcc	13	16	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:201868633G>A	uc001gxb.2	-	2	1756	c.1508C>T	c.(1507-1509)GCC>GTC	p.A503V	LMOD1_uc010ppu.1_Missense_Mutation_p.A452V	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	503					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						CTTAGCCACGGCCCCGGCCTT	0.582													0	0	0	0.005443	0	23	30										A	201868633	G	A	201868633	3	1	89	1	0	0	0	0	1	0	0	0	8856	1203	42	2	302	2	LMOD1	1	201868633	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	851977	201868633	47381988	37	26615										
RCOR3	55758	broad.mit.edu	37	chr1	211462527	211462527	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttattctcttagggtaataCtgaacaacctgtccaaacta	5	9	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:211462527C>T	uc001hig.2	+	7	723	c.554C>T	c.(553-555)ACT>ATT	p.T185I	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.T243I|RCOR3_uc010psw.1_Missense_Mutation_p.T243I|RCOR3_uc001hif.2_Missense_Mutation_p.T243I	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		TAGGGTAATACTGAACAACCT	0.378													0	0	0	0.013114	0	47	71										T	211462527	C	T	211462527	3	4	89	1	0	0	0	0	1	0	0	0	13184	565	20	2	758	2	RCOR3	1	211462527	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	9593894	211462527	37788094	38	26616										
LPGAT1	9926	broad.mit.edu	37	chr1	212002548	212002548	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatgtaggatggaatagcaaCcaggttgttgacgaccatga	13	6	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:212002548C>A	uc001hiu.2	-	2	904	c.91G>T	c.(91-93)GTT>TTT	p.V31F	LPGAT1_uc001hiv.2_Missense_Mutation_p.V31F	NM_014873	NP_055688	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	31	Helical; (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		GGAATAGCAACCAGGTTGTTG	0.463													1	0	2.66069e-56	0.01441	3.77668e-56	108	141										A	212002548	C	A	212002548	3	1	89	1	0	0	0	0	1	0	0	0	8914	507	18	4	1049	4	LPGAT1	1	212002548	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	540021	212002548	37248073	39	26617										
RPS6KC1	26750	broad.mit.edu	37	chr1	213224846	213224846	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acacagtatataaggtcaccGcccgggtgagtgccggtgtc	13	11	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:213224846G>T	uc010ptr.1	+	1	259	c.100G>T	c.(100-102)GCC>TCC	p.A34S	RPS6KC1_uc001hkd.2_Missense_Mutation_p.A34S|RPS6KC1_uc010pts.1_5'UTR|RPS6KC1_uc010ptt.1_5'UTR|RPS6KC1_uc010ptu.1_5'UTR|RPS6KC1_uc010ptv.1_5'UTR|RPS6KC1_uc009xdh.2_RNA	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	34	PX.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TAAGGTCACCGCCCGGGTGAG	0.627													1	0	0.00136819	0.013537	0.0013882	12	24										T	213224846	G	T	213224846	3	4	89	1	0	0	0	0	1	0	0	0	13658	1087	38	4	102	4	RPS6KC1	1	213224846	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1222298	213224846	36025775	40	26618										
KIAA1383	54627	broad.mit.edu	37	chr1	232942439	232942439	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atatgaccaacctgtgacaaGtcctgctcatatacatcctc	5	13	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:232942439G>T	uc001hvh.2	+	1	1802	c.1670G>T	c.(1669-1671)AGT>ATT	p.S557I		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	415										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				CCTGTGACAAGTCCTGCTCAT	0.413													1	0	3.62473e-10	0.012319	3.94456e-10	21	62										T	232942439	G	T	232942439	3	4	89	1	0	0	0	0	1	0	0	0	8228	1029	36	4	1672	4	KIAA1383	1	232942439	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	19717593	232942439	16308182	41	26619										
GNG4	2786	broad.mit.edu	37	chr1	235747123	235747123	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctagtggtgctgttattagAcatgccctctttcattctac	8	10	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:235747123A>G	uc001hxe.3	-	3	470	c.16T>C	c.(16-18)TCT>CCT	p.S6P	GNG4_uc009xfz.2_Missense_Mutation_p.S6P|GNG4_uc001hxh.3_Missense_Mutation_p.S6P	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	6					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			CTGTTATTAGACATGCCCTCT	0.507													0	0	0	0.01441	0	70	156										G	235747123	A	G	235747123	3	3	89	1	0	0	0	0	1	0	0	0	6529	275	10	5	219	5	GNG4	1	235747123	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	2804684	235747123	13503498	42	26620										
ACTN2	88	broad.mit.edu	37	chr1	236925893	236925893	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	attacgctgcgttctcttccGcactctacggggagagcgat	11	12	2	1	rs148972050		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:236925893G>A	uc001hyf.2	+	21	2863	c.2659G>A	c.(2659-2661)GCA>ACA	p.A887T	ACTN2_uc001hyg.2_Missense_Mutation_p.A679T|ACTN2_uc009xgi.1_Missense_Mutation_p.A887T|ACTN2_uc010pxu.1_Missense_Mutation_p.A576T|ACTN2_uc001hyh.2_Missense_Mutation_p.A575T	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	887					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GTTCTCTTCCGCACTCTACGG	0.552													0	0	0	0.00308	0	8	92										A	236925893	G	A	236925893	3	1	89	1	0	0	0	0	1	0	0	0	205	1087	38	2	2741	2	ACTN2	1	236925893	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1178770	236925893	12324728	43	26621										
RYR2	6262	broad.mit.edu	37	chr1	237753123	237753123	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgtgtgtagccttggagtggCtcaagtgggtaggatgaact	16	5	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:237753123C>A	uc001hyl.1	+	30	3749	c.3629C>A	c.(3628-3630)GCT>GAT	p.A1210D		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1210	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTGGAGTGGCTCAAGTGGGT	0.383													1	0	1.64293e-13	0.01892	1.8685e-13	23	39										A	237753123	C	A	237753123	3	1	89	1	0	0	0	0	1	0	0	0	13769	797	28	4	3747	4	RYR2	1	237753123	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	827230	237753123	11497498	44	26622										
FMN2	56776	broad.mit.edu	37	chr1	240374392	240374392	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcttttgcttaattttagaGactccagtacttcacttatt	4	8	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:240374392G>C	uc010pyd.1	+	6	4147	c.3922G>C	c.(3922-3924)GAC>CAC	p.D1308H	FMN2_uc010pye.1_Missense_Mutation_p.D1312H	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1308	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TAATTTTAGAGACTCCAGTAC	0.269													0	0	0	0.013114	0	45	37										C	240374392	G	C	240374392	3	2	89	1	0	0	0	0	1	0	0	0	5950	956	33	1	3944	1	FMN2	1	240374392	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2621269	240374392	8876229	45	26623										
OR2C3	81472	broad.mit.edu	37	chr1	247695441	247695441	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagtggcctgcagatggcagCgtagcggtcataggacatgg	17	8	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:247695441C>T	uc009xgy.2	-	2	735	c.373G>A	c.(373-375)GCT>ACT	p.A125T	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CAGATGGCAGCGTAGCGGTCA	0.562													0	0	0	0.004656	0	25	63										T	247695441	C	T	247695441	3	4	89	1	0	0	0	0	1	0	0	0	10993	768	27	2	593	2	OR2C3	1	247695441	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7321049	247695441	1555180	46	26624										
SNTG2	54221	broad.mit.edu	37	chr2	1168818	1168818	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaccacagcagtggggcctcCtctcccctctttgacagcgg	11	16	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:1168818C>T	uc002qwq.2	+	8	668	c.540C>T	c.(538-540)TCC>TCT	p.S180S	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	180					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTGGGGCCTCCTCTCCCCTCT	0.473													0	0	0	0.01441	0	113	18										T	1168818	C	T	1168818	2	4	89	1	0	0	0	0	0	0	0	1	14875	668	24	2		2	SNTG2	2	1168818	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		1168818	242030555	47	26625										
PXDN	7837	broad.mit.edu	37	chr2	1652481	1652481	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggtgatgtgctggatctccGcacccacgatcttcctggtc	11	13	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:1652481G>T	uc002qxa.2	-	17	3135	c.3071C>A	c.(3070-3072)GCG>GAG	p.A1024E		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1024					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CTGGATCTCCGCACCCACGAT	0.622													1	0	3.86212e-05	0.008291	3.94747e-05	11	0										T	1652481	G	T	1652481	3	4	89	1	0	0	0	0	1	0	0	0	12847	1087	38	4	1396	4	PXDN	2	1652481	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	483663	1652481	241546892	48	26626										
GEN1	348654	broad.mit.edu	37	chr2	17962140	17962140	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctaagacctttggctatacAgcaaattaaagctgtcagta	7	8	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:17962140A>C	uc002rct.2	+	14	1734	c.1661A>C	c.(1660-1662)CAG>CCG	p.Q554P	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.Q554P|GEN1_uc002rcu.2_Missense_Mutation_p.Q554P	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	554					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTGGCTATACAGCAAATTAAA	0.363								Homologous_recombination					0	0	0	0.010818	0	33	2										C	17962140	A	C	17962140	3	2	89	1	0	0	0	0	1	0	0	0	6335	188	7	5	1711	5	GEN1	2	17962140	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	16309659	17962140	225237233	49	26627										
BIRC6	57448	broad.mit.edu	37	chr2	32715215	32715215	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcatgacaaacatgcagcttAattgtaagttcataaattta	5	6	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:32715215A>C	uc010ezu.2	+	43	8337	c.8203A>C	c.(8203-8205)AAT>CAT	p.N2735H		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2735					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CATGCAGCTTAATTGTAAGTT	0.358													0	0	0	0.01441	0	67	7										C	32715215	A	C	32715215	3	2	89	1	0	0	0	0	1	0	0	0	1438	362	13	5	8373	5	BIRC6	2	32715215	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	14753075	32715215	210484158	50	26628										
OXER1	165140	broad.mit.edu	37	chr2	42990186	42990186	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagctctcgtcgctcactggGccctgccggccccgcgtgag	14	17	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:42990186G>A	uc002rss.2	-	1	1216	c.1134C>T	c.(1132-1134)GGC>GGT	p.G378G		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	378	Cytoplasmic (Potential).				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						CGCTCACTGGGCCCTGCCGGC	0.662													0	0	0	0.01441	0	51	2										A	42990186	G	A	42990186	2	1	89	1	0	0	0	0	0	0	0	1	11331	1190	42	2		2	OXER1	2	42990186	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	10274971	42990186	200209187	51	26629										
MSH2	4436	broad.mit.edu	37	chr2	47702220	47702220	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tagctcagctagatgctgttGtcagctttgctcacgtgtca	10	10	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:47702220G>T	uc002rvy.1	+	12	1884	c.1816G>T	c.(1816-1818)GTC>TTC	p.V606F	MSH2_uc010yoh.1_Missense_Mutation_p.V540F|MSH2_uc002rvz.2_Missense_Mutation_p.V606F|MSH2_uc010fbg.2_Missense_Mutation_p.V416F|MSH2_uc010fbi.1_RNA	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	606	Interaction with EXO1.				B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(2)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGATGCTGTTGTCAGCTTTGC	0.393			D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				1	0	3.4345e-17	0.011902	4.07296e-17	44	7										T	47702220	G	T	47702220	3	4	89	1	0	0	0	0	1	0	0	0	9870	1377	48	4	1862	4	MSH2	2	47702220	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4712034	47702220	195497153	52	26630										
FAM161A	84140	broad.mit.edu	37	chr2	62081096	62081096	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcttcgcgttcgtactgggcGacccgcgctccagtgatggg	14	13	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:62081096G>A	uc010ypo.1	-	1	183	c.81C>T	c.(79-81)GTC>GTT	p.V27V	FAM161A_uc002sbm.3_Silent_p.V27V|FAM161A_uc002sbn.3_5'UTR|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_5'UTR	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	27					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						CGTACTGGGCGACCCGCGCTC	0.667													0	0	0	0.006122	0	18	6										A	62081096	G	A	62081096	2	1	89	1	0	0	0	0	0	0	0	1	5472	1045	37	1		1	FAM161A	2	62081096	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	14378876	62081096	181118277	53	26631										
ASTL	431705	broad.mit.edu	37	chr2	96798412	96798412	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttctggagacacgtgggcgcCagggagaccacctgcatccc	13	14	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:96798412C>A	uc010yui.1	-	6	504	c.504G>T	c.(502-504)CTG>CTT	p.L168L		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	168					proteolysis		metalloendopeptidase activity|zinc ion binding				0						ACGTGGGCGCCAGGGAGACCA	0.652													1	0	5.34276e-22	0.01441	6.63362e-22	46	88										A	96798412	C	A	96798412	2	1	89	1	0	0	0	0	0	0	0	1	1063	581	21	4		4	ASTL	2	96798412	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	34717316	96798412	146400961	54	26632										
TMEM131	23505	broad.mit.edu	37	chr2	98422040	98422040	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttttttcctggctccaagtCttccttattgccccgtaatc	5	13	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:98422040C>T	uc002syh.3	-	20	2411	c.2182G>A	c.(2182-2184)GAC>AAC	p.D728N		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	728						integral to membrane				ovary(4)|central_nervous_system(2)	6						GGCTCCAAGTCTTCCTTATTG	0.343													0	0	0	0.01441	0	75	102										T	98422040	C	T	98422040	3	4	89	1	0	0	0	0	1	0	0	0	16041	913	32	1	3557	1	TMEM131	2	98422040	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1623628	98422040	144777333	55	26633										
SLC9A4	389015	broad.mit.edu	37	chr2	103120009	103120009	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccgattcatcgttgtggggCttggaggggtattgtttggc	16	7	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:103120009C>A	uc002tbz.3	+	3	1280	c.823C>A	c.(823-825)CTT>ATT	p.L275I		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	275	Helical; Name=H/M6; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CGTTGTGGGGCTTGGAGGGGT	0.388													1	0	5.35047e-06	0.01892	5.52982e-06	22	32										A	103120009	C	A	103120009	3	1	89	1	0	0	0	0	1	0	0	0	14716	797	28	4	833	4	SLC9A4	2	103120009	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4697969	103120009	140079364	56	26634										
PSD4	23550	broad.mit.edu	37	chr2	113941042	113941042	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctgctgggcctcagtggctGccgctgagggggctcctgca	16	13	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:113941042G>C	uc002tjc.2	+	2	1192	c.1009G>C	c.(1009-1011)GCC>CCC	p.A337P	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.A336P|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	337					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CTCAGTGGCTGCCGCTGAGGG	0.617													0	0	0	0.009535	0	29	32										C	113941042	G	C	113941042	3	2	89	1	0	0	0	0	1	0	0	0	12649	1319	46	4	1011	4	PSD4	2	113941042	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	10821033	113941042	129258331	57	26635										
INHBB	3625	broad.mit.edu	37	chr2	121107164	121107164	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acagttcttcattgacttccGcctcatcggctggaacgact	8	13	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:121107164G>C	uc002tmn.2	+	2	984	c.938G>C	c.(937-939)CGC>CCC	p.R313P		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	313					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				ATTGACTTCCGCCTCATCGGC	0.632													0	0	0	0.01441	0	71	91										C	121107164	G	C	121107164	3	2	89	1	0	0	0	0	1	0	0	0	7742	1087	38	4	944	4	INHBB	2	121107164	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7166122	121107164	122092209	58	26636										
BIN1	274	broad.mit.edu	37	chr2	127821519	127821519	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgggcctcacctgttccacaGggacggcagctcctcctgca	11	16	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:127821519G>A	uc002tns.1	-	8	1033	c.688C>T	c.(688-690)CTG>TTG	p.L230L	BIN1_uc010yzf.1_Silent_p.L175L|BIN1_uc010yzg.1_Silent_p.L230L|BIN1_uc002tnu.1_Silent_p.L199L|BIN1_uc002toa.1_Silent_p.L199L|BIN1_uc002tnt.1_Silent_p.L199L|BIN1_uc002tnv.1_Silent_p.L230L|BIN1_uc002tnw.1_Silent_p.L199L|BIN1_uc002tnx.1_Silent_p.L199L|BIN1_uc002tny.1_Silent_p.L230L|BIN1_uc002tnz.1_Silent_p.L199L|BIN1_uc002tob.1_Silent_p.L199L|BIN1_uc002toc.1_Silent_p.L199L	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	230	BAR.|Potential.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTGTTCCACAGGGACGGCAGC	0.652													0	0	0	0.01441	0	51	48										A	127821519	G	A	127821519	2	1	89	1	0	0	0	0	0	0	0	1	1432	991	35	2		2	BIN1	2	127821519	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	6714355	127821519	115377854	59	26637										
IMP4	92856	broad.mit.edu	37	chr2	131103212	131103212	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagtgggggcactggtgcgaGcctgcaaagccaacggcgtc	16	11	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:131103212G>T	uc002tra.1	+	5	396	c.379G>T	c.(379-381)GCC>TCC	p.A127S		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	127	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					ACTGGTGCGAGCCTGCAAAGC	0.647													1	0	1.26454e-06	0.005443	1.31674e-06	27	34										T	131103212	G	T	131103212	3	4	89	1	0	0	0	0	1	0	0	0	7720	971	34	4	397	4	IMP4	2	131103212	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3281693	131103212	112096161	60	26638										
FAM123C	205147	broad.mit.edu	37	chr2	131521341	131521341	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttgctcagcacccagcaggCaggagctgtgggcacacccg	13	14	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:131521341C>G	uc002trw.2	+	2	1886	c.1696C>G	c.(1696-1698)CAG>GAG	p.Q566E	FAM123C_uc010fmv.2_Missense_Mutation_p.Q566E|FAM123C_uc010fms.1_Missense_Mutation_p.Q566E|FAM123C_uc010fmt.1_Missense_Mutation_p.Q566E|FAM123C_uc010fmu.1_Missense_Mutation_p.Q566E	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	566										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		ACCCAGCAGGCAGGAGCTGTG	0.692													0	0	0	0.010504	0	19	26										G	131521341	C	G	131521341	3	3	89	1	0	0	0	0	1	0	0	0	5424	711	25	4	1698	4	FAM123C	2	131521341	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	418129	131521341	111678032	61	26639										
TUBA3D	113457	broad.mit.edu	37	chr2	132235813	132235813	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgggaactgtactgccttgAacatggaattcagcccgatg	11	10	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:132235813A>G	uc002tsu.3	+	2	187	c.80A>G	c.(79-81)GAA>GGA	p.E27G		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	27					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TACTGCCTTGAACATGGAATT	0.532													0	0	0	0.01441	0	53	97										G	132235813	A	G	132235813	3	3	89	1	0	0	0	0	1	0	0	0	16744	246	9	5	86	5	TUBA3D	2	132235813	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	714472	132235813	110963560	62	26640										
THSD7B	80731	broad.mit.edu	37	chr2	138414682	138414682	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagcaagtctttggaacaatAacgaacgaactgtatggtgc	10	7	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:138414682A>T	uc002tva.1	+	23	4240	c.4240A>T	c.(4240-4242)AAC>TAC	p.N1414Y	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGGAACAATAACGAACGAAC	0.418													0	0	0	0.013726	0	30	36										T	138414682	A	T	138414682	3	4	89	1	0	0	0	0	1	0	0	0	15877	362	13	5	4329	5	THSD7B	2	138414682	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	6178869	138414682	104784691	63	26641										
ARHGAP15	55843	broad.mit.edu	37	chr2	143959730	143959730	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gacacagaaggaatcattcaCagcatatcttgaaagatgtc	8	8	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:143959730C>T	uc002tvm.3	+	3	344	c.193C>T	c.(193-195)CAG>TAG	p.Q65*	ARHGAP15_uc010zbl.1_Nonsense_Mutation_p.Q65*	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	65					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GAATCATTCACAGCATATCTT	0.244													0	0	0	0.009535	0	25	53										T	143959730	C	T	143959730	4	4	89	1	0	0	0	0	0	1	0	0	866	479	17	2	199	2	ARHGAP15	2	143959730	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5545048	143959730	99239643	64	26642										
DPP4	1803	broad.mit.edu	37	chr2	162865119	162865119	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccacggctattccacacttgAacacgccacttcccgatccc	5	19	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:162865119A>G	uc002ubz.2	-	22	2501	c.1940T>C	c.(1939-1941)TTC>TCC	p.F647S	DPP4_uc010fpb.2_Missense_Mutation_p.F323S	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	647	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	TCCACACTTGAACACGCCACT	0.463													0	0	0	0.01441	0	45	51										G	162865119	A	G	162865119	3	3	89	1	0	0	0	0	1	0	0	0	4729	246	9	5	380	5	DPP4	2	162865119	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	18905389	162865119	80334254	65	26643										
SCN1A	6323	broad.mit.edu	37	chr2	166901824	166901824	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggaatgttctgaggcagttGccgttgctgcctgctatatt	12	8	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:166901824G>A	uc010zcz.1	-	10	1409	c.1391C>T	c.(1390-1392)GCA>GTA	p.A464V	SCN1A_uc002udo.3_Missense_Mutation_p.A333V|SCN1A_uc010fpk.2_Missense_Mutation_p.A333V	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	464						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGAGGCAGTTGCCGTTGCTGC	0.448													0	0	0	0.01441	0	53	91										A	166901824	G	A	166901824	3	1	89	1	0	0	0	0	1	0	0	0	13914	1319	46	2	4706	2	SCN1A	2	166901824	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4036705	166901824	76297549	66	26644										
SCN1A	6323	broad.mit.edu	37	chr2	166903446	166903446	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcccaagaaaatgaccaatAcaaaaaatatcatgtacgtt	5	8	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:166903446A>G	uc010zcz.1	-	9	1229	c.1211T>C	c.(1210-1212)GTA>GCA	p.V404A	SCN1A_uc002udo.3_Missense_Mutation_p.V273A|SCN1A_uc010fpk.2_Missense_Mutation_p.V273A	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	404	Helical; Name=S6 of repeat I; (By similarity).|I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATGACCAATACAAAAAATAT	0.398													0	0	0	0.01441	0	60	44										G	166903446	A	G	166903446	3	3	89	1	0	0	0	0	1	0	0	0	13914	391	14	5	4890	5	SCN1A	2	166903446	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1622	166903446	76295927	67	26645										
TTN	7273	broad.mit.edu	37	chr2	179403929	179403929	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	caggacaagctaacagaactCttggttacatcgagtacttc	8	10	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:179403929C>T	uc010zfg.1	-	302	91253	c.91029G>A	c.(91027-91029)AAG>AAA	p.K30343K	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K24038K|TTN_uc010zfi.1_Silent_p.K23971K|TTN_uc010zfj.1_Silent_p.K23846K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31270							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACAGAACTCTTGGTTACAT	0.458													0	0	0	0.010729	0	11	35										T	179403929	C	T	179403929	2	4	89	1	0	0	0	0	0	0	0	1	16732	912	32	1		1	TTN	2	179403929	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	12500483	179403929	63795444	68	26646										
TTN	7273	broad.mit.edu	37	chr2	179593726	179593726	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acttctgatttgaagtgtggCcacactgtccacaaatgaaa	8	9	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:179593726C>A	uc010zfg.1	-	62	15531	c.15307G>T	c.(15307-15309)GCC>TCC	p.A5103S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A1764S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6030							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGTGTGGCCACACTGTCC	0.413													1	0	1.02788e-11	0.00499	1.15248e-11	17	15										A	179593726	C	A	179593726	3	1	89	1	0	0	0	0	1	0	0	0	16732	739	26	4	85682	4	TTN	2	179593726	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	189797	179593726	63605647	69	26647										
CERKL	375298	broad.mit.edu	37	chr2	182403985	182403985	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtaagtctcaacaaatggaaAattgaactaaaaataaatac	5	5	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:182403985A>T	uc002unx.2	-	13	1551	c.1450T>A	c.(1450-1452)TTT>ATT	p.F484I	CERKL_uc002uny.2_Missense_Mutation_p.F458I|CERKL_uc010zfm.1_Missense_Mutation_p.F440I|CERKL_uc002unz.2_Missense_Mutation_p.F206I|CERKL_uc002uoa.2_Missense_Mutation_p.F389I|CERKL_uc002uob.2_Missense_Mutation_p.F206I|CERKL_uc002uoc.2_Missense_Mutation_p.F345I|CERKL_uc010frk.2_RNA|CERKL_uc002unw.2_Missense_Mutation_p.F54I	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	484					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ACAAATGGAAAATTGAACTAA	0.353													0	0	0	0.005443	0	26	29										T	182403985	A	T	182403985	3	4	89	1	0	0	0	0	1	0	0	0	3268	14	1	5	234	5	CERKL	2	182403985	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	2810259	182403985	60795388	70	26648										
SLC40A1	30061	broad.mit.edu	37	chr2	190428407	190428407	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acaatattagcagaattagaCccattagacatgtatatttc	5	7	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:190428407C>A	uc002uqp.3	-	7	1656	c.1305G>T	c.(1303-1305)GGG>GGT	p.G435G		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	435					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CAGAATTAGACCCATTAGACA	0.408													1	0	1.67305e-13	0.00623	1.89886e-13	41	49										A	190428407	C	A	190428407	2	1	89	1	0	0	0	0	0	0	0	1	14628	494	18	4		4	SLC40A1	2	190428407	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	8024422	190428407	52770966	71	26649										
MYO1B	4430	broad.mit.edu	37	chr2	192255219	192255219	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cattggaaaggaccagccagGtaagaaattcagtgaccata	10	8	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:192255219G>C	uc010fsg.2	+	18	2237	c.1982_splice	c.e18+1	p.R661_splice	MYO1B_uc002usq.2_Splice_Site_p.R661_splice|MYO1B_uc002usr.2_Splice_Site_p.R661_splice|MYO1B_uc002usu.2_5'Flank	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1							myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GACCAGCCAGGTAAGAAATTC	0.378													0	0	0	0.004007	0	16	20										C	192255219	G	C	192255219	5	2	89	1	0	0	0	0	0	0	1	0	10069	1275	44	4	2049	4	MYO1B	2	192255219	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1826812	192255219	50944154	72	26650										
NRP2	8828	broad.mit.edu	37	chr2	206631519	206631519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttttcagaacccatctcggCttttgcaggtgagaatttta	8	8	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:206631519C>T	uc002vaw.2	+	15	3208	c.2417C>T	c.(2416-2418)GCT>GTT	p.A806V	NRP2_uc002vau.2_Missense_Mutation_p.A806V|NRP2_uc002vav.2_Missense_Mutation_p.A806V|NRP2_uc002vax.2_Missense_Mutation_p.A806V|NRP2_uc002vay.2_Missense_Mutation_p.A806V	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	806	Extracellular (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CCCATCTCGGCTTTTGCAGGT	0.343											OREG0015156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	24	24										T	206631519	C	T	206631519	3	4	89	1	0	0	0	0	1	0	0	0	10661	797	28	2	2502	2	NRP2	2	206631519	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	14376300	206631519	36567854	73	26651										
ZDBF2	57683	broad.mit.edu	37	chr2	207170202	207170202	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaataaaactgacatgccttCtaataaaggaatctttgaag	7	6	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:207170202C>T	uc002vbp.2	+	5	1200	c.950C>T	c.(949-951)TCT>TTT	p.S317F		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	317							nucleic acid binding|zinc ion binding			ovary(3)	3						GACATGCCTTCTAATAAAGGA	0.368													0	0	0	0.004482	0	8	15										T	207170202	C	T	207170202	3	4	89	1	0	0	0	0	1	0	0	0	17596	913	32	1	960	1	ZDBF2	2	207170202	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	538683	207170202	36029171	74	26652										
FN1	2335	broad.mit.edu	37	chr2	216240428	216240428	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggtagatcttgtagtcagtGcctggttgtaaacctgggat	13	6	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:216240428G>A	uc002vfa.2	-	37	6167	c.5901C>T	c.(5899-5901)GGC>GGT	p.G1967G	FN1_uc002vfb.2_Silent_p.G1786G|FN1_uc002vfc.2_Silent_p.G1786G|FN1_uc002vfd.2_Silent_p.G1967G|FN1_uc002vfe.2_Silent_p.G1876G|FN1_uc002vff.2_Silent_p.G1876G|FN1_uc002vfg.2_Silent_p.G1786G|FN1_uc002vfh.2_Silent_p.G1786G|FN1_uc002vfi.2_Silent_p.G1967G|FN1_uc002vfj.2_Silent_p.G1877G|FN1_uc002vez.2_Silent_p.G161G|FN1_uc010zjp.1_Silent_p.G504G|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_RNA|FN1_uc010fvb.1_RNA|FN1_uc010fvc.1_Silent_p.G329G|FN1_uc010fvd.1_Intron	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1966	Binds to FBLN1.|Heparin-binding 2.|Fibronectin type-III 15.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTAGTCAGTGCCTGGTTGTA	0.438													0	0	0	0.004007	0	14	28										A	216240428	G	A	216240428	2	1	89	1	0	0	0	0	0	0	0	1	5962	1306	46	2		2	FN1	2	216240428	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	9070226	216240428	26958945	75	26653										
KCNJ13	3769	broad.mit.edu	37	chr2	233635823	233635823	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atcatgatctagttccagatCaccattcatctcagccagaa	5	12	5	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:233635823C>T	uc002vto.2	-	1	293	c.250G>A	c.(250-252)GAT>AAT	p.D84N	GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vti.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron|KCNJ13_uc002vtn.2_Intron|KCNJ13_uc002vtp.2_Missense_Mutation_p.D84N	NM_002242	NP_002233	O60928	IRK13_HUMAN	potassium inwardly-rectifying channel J13	84	Extracellular (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity				0		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		AGTTCCAGATCACCATTCATC	0.473													0	0	0	0.01441	0	57	42										T	233635823	C	T	233635823	3	4	89	1	0	0	0	0	1	0	0	0	8047	826	29	1	840	1	KCNJ13	2	233635823	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	17395395	233635823	9563550	76	26654										
COL6A3	1293	broad.mit.edu	37	chr2	238275417	238275417	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgctcgctcagttcggacaGctcctggacgttgcccacgc	11	15	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:238275417G>C	uc002vwl.2	-	11	5698	c.5413C>G	c.(5413-5415)CTG>GTG	p.L1805V	COL6A3_uc002vwo.2_Missense_Mutation_p.L1599V|COL6A3_uc010znj.1_Missense_Mutation_p.L1198V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1805	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGTTCGGACAGCTCCTGGACG	0.517													0	0	0	0.01441	0	69	88										C	238275417	G	C	238275417	3	2	89	1	0	0	0	0	1	0	0	0	3701	962	34	4	4256	4	COL6A3	2	238275417	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4639594	238275417	4923956	77	26655										
CNTN4	152330	broad.mit.edu	37	chr3	2908487	2908487	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccttcctatcaggataatcGccgctttgtttctcaagaga	7	12	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:2908487G>A	uc003bpc.2	+	7	727	c.506G>A	c.(505-507)CGC>CAC	p.R169H	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.R169H	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	169	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAGGATAATCGCCGCTTTGTT	0.388													0	0	0	0.01441	0	63	123										A	2908487	G	A	2908487	3	1	89	1	0	0	0	0	1	0	0	0	3643	1087	38	2	524	2	CNTN4	3	2908487	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		2908487	195113943	78	26656										
VGLL4	9686	broad.mit.edu	37	chr3	11600188	11600188	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagagctttggcaaagtggtCgtccacggagcccgtgatgg	15	10	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:11600188C>G	uc003bwf.2	-	6	1081	c.715G>C	c.(715-717)GAC>CAC	p.D239H	VGLL4_uc010hdx.1_Missense_Mutation_p.D245H|VGLL4_uc003bwg.2_Missense_Mutation_p.D244H|VGLL4_uc010hdv.1_Missense_Mutation_p.D155H|VGLL4_uc010hdw.1_Missense_Mutation_p.D159H|VGLL4_uc011aun.1_Missense_Mutation_p.D180H	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		GCAAAGTGGTCGTCCACGGAG	0.642													0	0	0	0.01441	0	123	146										G	11600188	C	G	11600188	3	3	89	1	0	0	0	0	1	0	0	0	17158	884	31	1	161	1	VGLL4	3	11600188	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	8691701	11600188	186422242	79	26657										
PPARG	5468	broad.mit.edu	37	chr3	12422901	12422902	+	Frame_Shift_Ins	INS	-	-	C													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taagcctcatgaagagccttINSccaactccctcatggcaatt							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:12422901_12422902insC	uc003bwx.2	+	3	482_483	c.391_392insC	c.(391-393)TCCfs	p.S131fs	PPARG_uc003bwr.2_Frame_Shift_Ins_p.S103fs|PPARG_uc003bws.2_Frame_Shift_Ins_p.S103fs|PPARG_uc003bwu.2_Frame_Shift_Ins_p.S103fs|PPARG_uc003bwv.2_Frame_Shift_Ins_p.S103fs|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Frame_Shift_Ins_p.S103fs|PPARG_uc003bwt.1_Frame_Shift_Ins_p.S103fs|PPARG_uc003bww.1_Frame_Shift_Ins_p.S131fs	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	131					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TGAAGAGCCTTCCAACTCCCTC	0.426			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension											15	72	---	---								C	12422902	-	C	12422901	7	5	89	1	0	1	1	0	0	0	0	0	12299	1783	62	0	401	0	PPARG	3	12422901	Frame_Shift_Ins	INS	-	TCGA-FJ-A3ZE-01A-11D-A23M-08	822713	12422901	185599529	80	26658										
KCNH8	131096	broad.mit.edu	37	chr3	19389402	19389402	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	attggcaatgacgacctgtcCacaactcggagcacaaccgt	9	13	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:19389402C>A	uc003cbk.1	+	5	951	c.756C>A	c.(754-756)TCC>TCA	p.S252S	KCNH8_uc011awe.1_Silent_p.S252S|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	252	Extracellular (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						ACGACCTGTCCACAACTCGGA	0.418													1	0	1.47544e-110	0.01441	2.12142e-110	239	113										A	19389402	C	A	19389402	2	1	89	1	0	0	0	0	0	0	0	1	8038	581	21	4		4	KCNH8	3	19389402	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6966501	19389402	178633028	81	26659										
EFHB	151651	broad.mit.edu	37	chr3	19925991	19925991	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggtctcagaagtgtccggaGagtcttttctgtgcttcctg	12	9	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:19925991G>C	uc003cbl.3	-	11	2246	c.2050C>G	c.(2050-2052)CTC>GTC	p.L684V	EFHB_uc003cbm.2_Missense_Mutation_p.L554V	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						AGTGTCCGGAGAGTCTTTTCT	0.393													0	0	0	0.011902	0	46	124										C	19925991	G	C	19925991	3	2	89	1	0	0	0	0	1	0	0	0	4945	942	33	1	463	1	EFHB	3	19925991	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	536589	19925991	178096439	82	26660										
NEK10	152110	broad.mit.edu	37	chr3	27326389	27326389	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggtgatgtttttccttcaaaGaactgaaatgctctccaagc	8	9	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:27326389G>T	uc003cdt.1	-	22	2127	c.1853C>A	c.(1852-1854)TCT>TAT	p.S618Y	NEK10_uc003cds.1_Missense_Mutation_p.S15Y	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	618	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTCCTTCAAAGAACTGAAATG	0.313													1	0	4.22769e-11	0.00632	4.67404e-11	25	131										T	27326389	G	T	27326389	3	4	89	1	0	0	0	0	1	0	0	0	10322	942	33	3	301	3	NEK10	3	27326389	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7400398	27326389	170696041	83	26661										
SCN5A	6331	broad.mit.edu	37	chr3	38649641	38649641	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggggtggtaggtgccacataCccagcgtcagagctgttccc	14	12	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:38649641C>T	uc003cio.2	-	8	1192	c.998_splice	c.e8+1	p.G333_splice	SCN5A_uc003cin.2_Splice_Site_p.G333_splice|SCN5A_uc003cil.3_Splice_Site_p.G333_splice|SCN5A_uc010hhi.2_Splice_Site_p.G333_splice|SCN5A_uc010hhk.2_Splice_Site_p.G333_splice|SCN5A_uc011ayr.1_Splice_Site_p.G333_splice|SCN5A_uc010hhj.1_5'Flank	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha						blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGCCACATACCCAGCGTCAG	0.522													0	0	0	0.01441	0	228	129										T	38649641	C	T	38649641	5	4	89	1	0	0	0	0	0	0	1	0	13922	521	18	2	5135	2	SCN5A	3	38649641	Splice_Site	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	11323252	38649641	159372789	84	26662										
CELSR3	1951	broad.mit.edu	37	chr3	48684347	48684347	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggtggagttttctatgctgcTgcttgtgggcagaactgcca	14	8	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:48684347T>C	uc003cul.2	-	21	7425	c.7144A>G	c.(7144-7146)AGC>GGC	p.S2382G	CELSR3_uc003cuf.1_Missense_Mutation_p.S2452G|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.S365G	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2382	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTATGCTGCTGCTTGTGGGC	0.572													0	0	0	0.004482	0	9	2										C	48684347	T	C	48684347	3	2	89	1	0	0	0	0	1	0	0	0	3223	1580	55	5	2854	5	CELSR3	3	48684347	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	10034706	48684347	149338083	85	26663										
HTR1F	3355	broad.mit.edu	37	chr3	88039908	88039908	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaaacaaagaaaatggatttCttaaattcatctgatcaaaa	4	5	4	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:88039908C>A	uc003dqr.2	+	2	167	c.9C>A	c.(7-9)TTC>TTA	p.F3L		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	3	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	AAATGGATTTCTTAAATTCAT	0.368													1	0	6.97489e-18	0.021022	8.34281e-18	38	65										A	88039908	C	A	88039908	3	1	89	1	0	0	0	0	1	0	0	0	7440	912	32	3	11	3	HTR1F	3	88039908	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	39355561	88039908	109982522	86	26664										
SIDT1	54847	broad.mit.edu	37	chr3	113286403	113286403	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcagataccagaggagctacAactatcaagaagtgagccgc	10	10	2	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:113286403A>G	uc003eak.2	+	3	1012	c.361A>G	c.(361-363)AAC>GAC	p.N121D	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.N121D|SIDT1_uc011big.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	121	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						GAGGAGCTACAACTATCAAGA	0.468													0	0	0	0.01441	0	59	101										G	113286403	A	G	113286403	3	3	89	1	0	0	0	0	1	0	0	0	14302	130	5	5	371	5	SIDT1	3	113286403	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	25246495	113286403	84736027	87	26665										
LSAMP	4045	broad.mit.edu	37	chr3	115805390	115805390	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggccacctttgagttcttgtCttctacaacgcacctgacag	8	13	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:115805390C>A	uc003ebt.2	-	2	669	c.169G>T	c.(169-171)GAC>TAC	p.D57Y	LSAMP_uc011bis.1_Missense_Mutation_p.D57Y	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	57	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GAGTTCTTGTCTTCTACAACG	0.458													1	0	1.76056e-25	0.011902	2.23595e-25	40	27										A	115805390	C	A	115805390	3	1	89	1	0	0	0	0	1	0	0	0	9048	913	32	3	871	3	LSAMP	3	115805390	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2518987	115805390	82217040	88	26666										
ARHGAP31	57514	broad.mit.edu	37	chr3	119128361	119128361	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcttctgtacctaagaaggCaggtcttgaggatgccaagg	13	8	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:119128361C>A	uc003ecj.3	+	11	2196	c.1664C>A	c.(1663-1665)GCA>GAA	p.A555E		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	555					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						CCTAAGAAGGCAGGTCTTGAG	0.517													1	0	1.05317e-09	0.020292	1.13718e-09	14	29										A	119128361	C	A	119128361	3	1	89	1	0	0	0	0	1	0	0	0	880	710	25	4	1706	4	ARHGAP31	3	119128361	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3322971	119128361	78894069	89	26667										
KALRN	8997	broad.mit.edu	37	chr3	124048787	124048787	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatgcaagacctagagctggCaatccaccaccaccagacct	8	15	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:124048787C>G	uc003ehg.2	+	8	1485	c.1358C>G	c.(1357-1359)GCA>GGA	p.A453G	KALRN_uc010hrv.1_Missense_Mutation_p.A453G|KALRN_uc003ehf.1_Missense_Mutation_p.A453G|KALRN_uc011bjy.1_Missense_Mutation_p.A453G	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	453					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTAGAGCTGGCAATCCACCAC	0.562													0	0	0	0.01441	0	71	71										G	124048787	C	G	124048787	3	3	89	1	0	0	0	0	1	0	0	0	7975	710	25	4	1388	4	KALRN	3	124048787	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4920426	124048787	73973643	90	26668										
PLXND1	23129	broad.mit.edu	37	chr3	129284333	129284333	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcatgatgctggtgtagtaCtccagcttgccgtgcagcgc	12	11	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:129284333C>A	uc003emx.2	-	25	4471	c.4371G>T	c.(4369-4371)GAG>GAT	p.E1457D	PLXND1_uc011blb.1_Missense_Mutation_p.E125D	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1457	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGTGTAGTACTCCAGCTTGC	0.632													1	0	2.69673e-31	0.01441	3.58059e-31	67	54										A	129284333	C	A	129284333	3	1	89	1	0	0	0	0	1	0	0	0	12127	564	20	4	1454	4	PLXND1	3	129284333	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5235546	129284333	68738097	91	26669										
MRPL3	11222	broad.mit.edu	37	chr3	131208827	131208827	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccccaacctcaaattacctGgtttaattgcagcattatct	4	12	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:131208827G>T	uc003eoh.2	-	5	730	c.566C>A	c.(565-567)CCA>CAA	p.P189Q	MRPL3_uc011blo.1_Missense_Mutation_p.P84Q|MRPL3_uc011blp.1_Missense_Mutation_p.P216Q	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	189					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						CAAATTACCTGGTTTAATTGC	0.363													1	0	1.61879e-10	0.013537	1.76509e-10	11	17										T	131208827	G	T	131208827	3	4	89	1	0	0	0	0	1	0	0	0	9793	1348	47	4	504	4	MRPL3	3	131208827	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1924494	131208827	66813603	92	26670										
P2RY14	9934	broad.mit.edu	37	chr3	150931787	150931787	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccaaagaacacaatgctgacGtacatgttgacgtagaagag	10	8	0	5			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:150931787G>A	uc003eyr.1	-	3	796	c.318C>T	c.(316-318)TAC>TAT	p.Y106Y	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Silent_p.Y106Y	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	106	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAATGCTGACGTACATGTTGA	0.458													0	0	0	0.019004	0	38	33										A	150931787	G	A	150931787	2	1	89	1	0	0	0	0	0	0	0	1	11351	1140	40	2		2	P2RY14	3	150931787	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	19722960	150931787	47090643	93	26671										
GMPS	8833	broad.mit.edu	37	chr3	155615800	155615800	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcaatattcactattggcaaGcctgttcttggaatttgcta	8	8	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:155615800G>T	uc003faq.2	+	3	629	c.294G>T	c.(292-294)AAG>AAT	p.K98N	GMPS_uc011bom.1_Intron	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	98	Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTATTGGCAAGCCTGTTCTTG	0.368			T	MLL	AML								1	0	1.09856e-86	0.01441	1.57546e-86	152	156										T	155615800	G	T	155615800	3	4	89	1	0	0	0	0	1	0	0	0	6498	962	34	4	304	4	GMPS	3	155615800	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4684013	155615800	42406630	94	26672										
TRIM59	286827	broad.mit.edu	37	chr3	160156689	160156689	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtaatgttcagggcaggtgaCaatatctggatggtcttctt	12	6	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:160156689C>A	uc003fdm.2	-	3	478	c.283G>T	c.(283-285)GTC>TTC	p.V95F	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	95	B box-type.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGGCAGGTGACAATATCTGGA	0.363													1	0	1.47244e-24	0.00623	1.85729e-24	39	58										A	160156689	C	A	160156689	3	1	89	1	0	0	0	0	1	0	0	0	16529	478	17	4	932	4	TRIM59	3	160156689	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4540889	160156689	37865741	95	26673										
SLITRK3	22865	broad.mit.edu	37	chr3	164907895	164907895	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttccagccaactcttcagttGtacaatttcacatgtacagt	5	11	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:164907895G>T	uc003fej.3	-	2	1168	c.724C>A	c.(724-726)CAA>AAA	p.Q242K	SLITRK3_uc003fek.2_Missense_Mutation_p.Q242K	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	242	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTCTTCAGTTGTACAATTTCA	0.463										HNSCC(40;0.11)			1	0	1.23713e-20	0.01441	1.51569e-20	47	93										T	164907895	G	T	164907895	3	4	89	1	0	0	0	0	1	0	0	0	14744	1386	48	4	2213	4	SLITRK3	3	164907895	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4751206	164907895	33114535	96	26674										
MAP3K13	9175	broad.mit.edu	37	chr3	185198111	185198111	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagaagagggaaataccagtGaccactcaaacagtcctgat	10	9	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:185198111G>A	uc010hyf.2	+	14	2859	c.2593G>A	c.(2593-2595)GAC>AAC	p.D865N	MAP3K13_uc011brt.1_Missense_Mutation_p.D658N|MAP3K13_uc011bru.1_Missense_Mutation_p.D721N|MAP3K13_uc003fpi.2_Missense_Mutation_p.D865N|MAP3K13_uc010hyg.2_Missense_Mutation_p.D555N	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	865					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAATACCAGTGACCACTCAAA	0.488													0	0	0	0.01441	0	86	77										A	185198111	G	A	185198111	3	1	89	1	0	0	0	0	1	0	0	0	9247	1290	45	1	2639	1	MAP3K13	3	185198111	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	20290216	185198111	12824319	97	26675										
CCDC50	152137	broad.mit.edu	37	chr3	191074896	191074896	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtatgccgagattttgctgtCctggaggaccacaccctggc	12	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:191074896C>T	uc003fsw.2	+	2	659	c.69C>T	c.(67-69)GTC>GTT	p.V23V	CCDC50_uc003fsv.2_Silent_p.V23V	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	23						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		ATTTTGCTGTCCTGGAGGACC	0.398													0	0	0	0.008361	0	28	51										T	191074896	C	T	191074896	2	4	89	1	0	0	0	0	0	0	0	1	2820	842	30	1		1	CCDC50	3	191074896	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5876785	191074896	6947534	98	26676										
PCYT1A	5130	broad.mit.edu	37	chr3	195968895	195968895	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcgcatacacatcataatccCgcacaattcgggtgatgatg	8	11	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:195968895C>T	uc003fwg.2	-	8	805	c.632G>A	c.(631-633)CGG>CAG	p.R211Q	PCYT1A_uc003fwh.2_Missense_Mutation_p.R211Q	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	211	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	ATCATAATCCCGCACAATTCG	0.488													0	0	0	0.01441	0	54	97										T	195968895	C	T	195968895	3	4	89	1	0	0	0	0	1	0	0	0	11610	652	23	2	483	2	PCYT1A	3	195968895	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4893999	195968895	2053535	99	26677										
ZNF141	7700	broad.mit.edu	37	chr4	367619	367619	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagcctttaaacggttctcaCacctgaataaacataagaaa	5	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:367619C>A	uc003gaa.2	+	5	1571	c.1393C>A	c.(1393-1395)CAC>AAC	p.H465N	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	465	C2H2-type 11.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						ACGGTTCTCACACCTGAATAA	0.333													1	0	1.47857e-17	0.01441	1.76475e-17	49	50										A	367619	C	A	367619	3	1	89	1	0	0	0	0	1	0	0	0	17727	478	17	4	1407	4	ZNF141	4	367619	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		367619	190786657	100	26678										
FAM53A	152877	broad.mit.edu	37	chr4	1656734	1656734	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttcaggaagtccaaggatgGgcgtgtccacctggcgtcct	13	11	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1656734G>A	uc011bve.1	-	4	1051	c.853C>T	c.(853-855)CCA>TCA	p.P285S	FAM53A_uc010ibw.2_Missense_Mutation_p.P285S	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	285						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			TCCAAGGATGGGCGTGTCCAC	0.647													0	0	0	0.007291	0	27	54										A	1656734	G	A	1656734	3	1	89	1	0	0	0	0	1	0	0	0	5579	1232	43	2	351	2	FAM53A	4	1656734	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1289115	1656734	189497542	101	26679										
FGFR3	2261	broad.mit.edu	37	chr4	1803564	1803564	+	Missense_Mutation	SNP	C	C	T													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgtcatctgcccccacagagCgctccccgcaccggcccatc					rs121913482		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1803564C>T	uc003gdr.3	+	7	998	c.742C>T	c.(742-744)CGC>TGC	p.R248C	FGFR3_uc003gdu.2_Missense_Mutation_p.R248C|FGFR3_uc003gds.3_Missense_Mutation_p.R248C|FGFR3_uc003gdq.3_Missense_Mutation_p.R248C|FGFR3_uc010icb.1_Missense_Mutation_p.R90C|FGFR3_uc003gdt.1_Missense_Mutation_p.R90C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	248	Extracellular (Potential).		R -> C (in KERSEB, bladder cancer, keratinocytic non-epidermolytic nevus and TD1; severe and lethal; also found as somatic mutation in one patient with multiple myeloma).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.R248C(291)|p.R248_S249insC(2)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCCCACAGAGCGCTCCCCGCA	0.567		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00308	0	6	37										T	1803564	C	T	1803564	3	4	89	1	0	0	0	0	1	0	0	0	5867	768	27	2	764	2	FGFR3	4	1803564	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	146830	1803564	189350712	102	26680	131	2								
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atctgcccccacagagcgctCcccgcaccggcccatcctgc					rs121913483		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.006214	0	7	37										G	1803568	C	G	1803568	3	3	89	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4	1803568	189350708	103	26681	131	2								
NOP14	8602	broad.mit.edu	37	chr4	2941321	2941327	+	Frame_Shift_Del	DEL	GGCAGAG	GGCAGAG	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cttctcacaggtcagcggccGgcagagctgcttctggcttt					rs138901812	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:2941321_2941327delGGCAGAG	uc003ggj.1	-	16	2317_2323	c.2245_2251delCTCTGCC	c.(2245-2253)CTCTGCCGGfs	p.L749fs	C4orf10_uc003ggd.1_Intron|C4orf10_uc003gge.1_Intron|C4orf10_uc003ggg.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Intron|NOP14_uc003ggk.3_Frame_Shift_Del_p.L749fs|NOP14_uc003ggl.2_Frame_Shift_Del_p.L749fs	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	749_751					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						GTCAGCGGCCGGCAGAGCTGCTTCTGG	0.589																		17	49	---	---								-	2941327	GGCAGAG	-	2941321	7	5	89	1	0	1	0	1	0	0	0	0	10536	1115	39	0	334	0	NOP14	4	2941321	Frame_Shift_Del	DEL	GGCAGAG	TCGA-FJ-A3ZE-01A-11D-A23M-08	1137753	2941321	188212955	104	26682										
STX18	53407	broad.mit.edu	37	chr4	4459161	4459161	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgaaatacttttcaagtaaTcttcaatgaaatccaaaaca	3	7	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:4459161T>A	uc003gic.2	-	4	503	c.419A>T	c.(418-420)GAT>GTT	p.D140V		NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	140	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		TTTCAAGTAATCTTCAATGAA	0.378													0	0	0	0.010818	0	32	21										A	4459161	T	A	4459161	3	1	89	1	0	0	0	0	1	0	0	0	15340	1435	50	5	620	5	STX18	4	4459161	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1517840	4459161	186695115	105	26683										
ACOX3	8310	broad.mit.edu	37	chr4	8383332	8383332	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccacttgtatgctgccagggCgacttcggaatgacaaacag	11	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:8383332C>T	uc010idk.2	-	14	1685	c.1540G>A	c.(1540-1542)GCC>ACC	p.A514T	ACOX3_uc003glc.3_Missense_Mutation_p.A514T|ACOX3_uc003gld.3_Missense_Mutation_p.A514T|ACOX3_uc003gle.1_Missense_Mutation_p.A419T	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	514					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						GCTGCCAGGGCGACTTCGGAA	0.398													0	0	0	0.004656	0	27	44										T	8383332	C	T	8383332	3	4	89	1	0	0	0	0	1	0	0	0	160	768	27	2	582	2	ACOX3	4	8383332	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3924171	8383332	182770944	106	26684										
WDR1	9948	broad.mit.edu	37	chr4	10084738	10084738	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcatccacggtcatcctggaCacctggttcgtgtggccttt	10	13	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:10084738C>A	uc003gmf.2	-	10	1387	c.1104G>T	c.(1102-1104)GTG>GTT	p.V368V	WDR1_uc003gmg.2_Silent_p.V228V|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	368	WD 7.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TCATCCTGGACACCTGGTTCG	0.602													1	0	5.03518e-11	0.007413	5.5447e-11	18	26										A	10084738	C	A	10084738	2	1	89	1	0	0	0	0	0	0	0	1	17269	465	17	4		4	WDR1	4	10084738	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1701406	10084738	181069538	107	26685										
WDR1	9948	broad.mit.edu	37	chr4	10100674	10100674	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtcttcagtccaagcaatgtCtttgatcttcccagcgaaag	8	11	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:10100674C>A	uc003gmf.2	-	4	602	c.319G>T	c.(319-321)GAC>TAC	p.D107Y	WDR1_uc003gmg.2_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	107	WD 2.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CAAGCAATGTCTTTGATCTTC	0.557													1	0	2.0833e-19	0.01441	2.51355e-19	50	79										A	10100674	C	A	10100674	3	1	89	1	0	0	0	0	1	0	0	0	17269	913	32	3	1549	3	WDR1	4	10100674	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	15936	10100674	181053602	108	26686										
AMBN	258	broad.mit.edu	37	chr4	71472154	71472154	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agctagaacctgctccccacGcagggctccttgctctccct	8	18	1	1	rs141401324		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:71472154G>A	uc003hfl.2	+	13	1126	c.1051G>A	c.(1051-1053)GCA>ACA	p.A351T		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	351					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TGCTCCCCACGCAGGGCTCCT	0.587													0	0	0	0.008291	0	11	40										A	71472154	G	A	71472154	3	1	89	1	0	0	0	0	1	0	0	0	563	1087	38	2	1101	2	AMBN	4	71472154	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	61371480	71472154	119682122	109	26687										
NPFFR2	10886	broad.mit.edu	37	chr4	73013158	73013158	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggactctaatgatgctctcaGactacgctgacctttctcca	7	13	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:73013158G>A	uc003hgg.2	+	4	1296	c.1198G>A	c.(1198-1200)GAC>AAC	p.D400N	NPFFR2_uc010iig.1_Missense_Mutation_p.D182N|NPFFR2_uc003hgi.2_Missense_Mutation_p.D301N|NPFFR2_uc003hgh.2_Missense_Mutation_p.D298N|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	400	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GATGCTCTCAGACTACGCTGA	0.478													0	0	0	0.01441	0	49	49										A	73013158	G	A	73013158	3	1	89	1	0	0	0	0	1	0	0	0	10578	942	33	1	1218	1	NPFFR2	4	73013158	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1541004	73013158	118141118	110	26688										
PARM1	25849	broad.mit.edu	37	chr4	75937717	75937717	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtaccaccgaccaccatctgGactagctctccacaaaacac	5	17	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:75937717G>T	uc003hih.1	+	2	366	c.126G>T	c.(124-126)TGG>TGT	p.W42C		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	prostatic androgen-repressed message-1	42	Extracellular (Potential).				positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1						CCACCATCTGGACTAGCTCTC	0.522													1	0	2.80507e-11	0.012213	3.11363e-11	32	56										T	75937717	G	T	75937717	3	4	89	1	0	0	0	0	1	0	0	0	11452	1183	41	3	132	3	PARM1	4	75937717	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2924559	75937717	115216559	111	26689										
WDFY3	23001	broad.mit.edu	37	chr4	85598394	85598394	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agttcctgcaatggtgtcgtCtttctgtgagtgaaaacctc	10	9	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:85598394C>G	uc003hpd.2	-	67	10823	c.10415G>C	c.(10414-10416)AGA>ACA	p.R3472T	WDFY3_uc003hpc.2_Missense_Mutation_p.R227T	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3472	FYVE-type.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATGGTGTCGTCTTTCTGTGAG	0.468													0	0	0	0.005524	0	35	71										G	85598394	C	G	85598394	3	3	89	1	0	0	0	0	1	0	0	0	17267	913	32	1	173	1	WDFY3	4	85598394	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	9660677	85598394	105555882	112	26690										
MMRN1	22915	broad.mit.edu	37	chr4	90856744	90856744	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatggacaaaatgagtgagcAactaaatgatttgacttatg	10	4	0	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:90856744A>G	uc003hst.2	+	6	1984	c.1913A>G	c.(1912-1914)CAA>CGA	p.Q638R	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.Q380R	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	638	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATGAGTGAGCAACTAAATGAT	0.378													0	0	0	0.005524	0	38	66										G	90856744	A	G	90856744	3	3	89	1	0	0	0	0	1	0	0	0	9670	130	5	5	1935	5	MMRN1	4	90856744	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	5258350	90856744	100297532	113	26691										
GRID2	2895	broad.mit.edu	37	chr4	94343960	94343960	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtctctgaaaatgtcttgggTaagccgaagaaataccaggg	12	7	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:94343960T>A	uc011cdt.1	+	10	1644	c.1386T>A	c.(1384-1386)GGT>GGA	p.G462G	GRID2_uc011cdu.1_Silent_p.G367G	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	462	Extracellular (Potential).			G -> C (in Ref. 1; AAC39579).	glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATGTCTTGGGTAAGCCGAAGA	0.383													0	0	0	0.013726	0	33	33										A	94343960	T	A	94343960	2	1	89	1	0	0	0	0	0	0	0	1	6772	1625	57	5		5	GRID2	4	94343960	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	3487216	94343960	96810316	114	26692										
UNC5C	8633	broad.mit.edu	37	chr4	96222783	96222783	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgcgcacatacgccttccggCtctttgtggtacccgcggag	12	14	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:96222783C>T	uc003htp.1	-	3	618	c.464G>A	c.(463-465)AGC>AAC	p.S155N	UNC5C_uc010ilc.1_Missense_Mutation_p.S155N|UNC5C_uc003htq.2_Missense_Mutation_p.S155N	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	155	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CGCCTTCCGGCTCTTTGTGGT	0.498													0	0	0	0.01441	0	49	40										T	96222783	C	T	96222783	3	4	89	1	0	0	0	0	1	0	0	0	16990	797	28	2	2387	2	UNC5C	4	96222783	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1878823	96222783	94931493	115	26693										
NPNT	255743	broad.mit.edu	37	chr4	106858277	106858277	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatgctcatgccggatggttCctgctcaagtatgtcaagaa	10	9	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:106858277C>T	uc003hya.2	+	4	582	c.377C>T	c.(376-378)TCC>TTC	p.S126F	NPNT_uc011cfc.1_Missense_Mutation_p.S143F|NPNT_uc011cfd.1_Missense_Mutation_p.S156F|NPNT_uc011cfe.1_Missense_Mutation_p.S156F|NPNT_uc010ilt.1_Missense_Mutation_p.S126F|NPNT_uc011cff.1_Missense_Mutation_p.S126F|NPNT_uc010ilu.1_Missense_Mutation_p.S22F	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	126	EGF-like 2; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CCGGATGGTTCCTGCTCAAGT	0.488													0	0	0	0.019004	0	35	95										T	106858277	C	T	106858277	3	4	89	1	0	0	0	0	1	0	0	0	10590	855	30	1	540	1	NPNT	4	106858277	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	10635494	106858277	84295999	116	26694										
ANK2	287	broad.mit.edu	37	chr4	114276414	114276414	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgagggggtagccggctctCcgtgtggcagcctgatggag	18	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:114276414C>A	uc003ibe.3	+	38	6740	c.6640C>A	c.(6640-6642)CCG>ACG	p.P2214T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.P2229T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2181					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCGGCTCTCCGTGTGGCAG	0.517													1	0	1.07234e-20	0.01441	1.31671e-20	50	74										A	114276414	C	A	114276414	3	1	89	1	0	0	0	0	1	0	0	0	621	855	30	3	6855	3	ANK2	4	114276414	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7418137	114276414	76877862	117	26695										
C4orf31	79625	broad.mit.edu	37	chr4	121958321	121958321	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttttggagaaggctttgcctGgaaactgcgttctttacctg	11	8	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:121958321G>A	uc003idq.1	-	4	1332	c.805C>T	c.(805-807)CAG>TAG	p.Q269*		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	269	Fibronectin type-III 1.										0						GGCTTTGCCTGGAAACTGCGT	0.463													0	0	0	0.01892	0	24	41										A	121958321	G	A	121958321	4	1	89	1	0	0	0	0	0	1	0	0	2261	1357	47	2	905	2	C4orf31	4	121958321	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7681907	121958321	69195955	118	26696										
FAT4	79633	broad.mit.edu	37	chr4	126336381	126336381	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaacagctatattgagtacaCtctgctgaaccctttgggaa	8	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:126336381C>T	uc003ifj.3	+	5	6263	c.6263C>T	c.(6262-6264)ACT>ATT	p.T2088I	FAT4_uc011cgp.1_Missense_Mutation_p.T386I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2088	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATTGAGTACACTCTGCTGAAC	0.403													0	0	0	0.01441	0	97	91										T	126336381	C	T	126336381	3	4	89	1	0	0	0	0	1	0	0	0	5692	565	20	2	6281	2	FAT4	4	126336381	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4378060	126336381	64817895	119	26697										
ZNF827	152485	broad.mit.edu	37	chr4	146807045	146807045	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agacgccagcccctccctggCtagtcctctctggagtgtta	10	15	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:146807045C>A	uc003ikn.2	-	4	1580	c.1532G>T	c.(1531-1533)AGC>ATC	p.S511I	ZNF827_uc003ikm.2_Missense_Mutation_p.S511I|ZNF827_uc010iox.2_Missense_Mutation_p.S161I	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					CCCTCCCTGGCTAGTCCTCTC	0.602													1	0	4.96213e-28	0.01441	6.41954e-28	57	47										A	146807045	C	A	146807045	3	1	89	1	0	0	0	0	1	0	0	0	18177	797	28	4	1741	4	ZNF827	4	146807045	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	20470664	146807045	44347231	120	26698										
DCHS2	54798	broad.mit.edu	37	chr4	155158070	155158070	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acatatgtgttttcacgggtCcagtcatggtcgatgtttga	11	7	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:155158070C>A	uc003inw.2	-	25	6369	c.6369G>T	c.(6367-6369)TGG>TGT	p.W2123C		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2123	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTTCACGGGTCCAGTCATGGT	0.378													1	0	6.3091e-27	0.01441	8.06809e-27	58	70										A	155158070	C	A	155158070	3	1	89	1	0	0	0	0	1	0	0	0	4288	856	30	3	2385	3	DCHS2	4	155158070	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	8351025	155158070	35996206	121	26699										
FSTL5	56884	broad.mit.edu	37	chr4	162463736	162463736	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtaatatcaattccattcttCaaccagccaagctgaggctt	6	11	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:162463736C>T	uc003iqh.2	-	9	1561	c.1125G>A	c.(1123-1125)TTG>TTA	p.L375L	FSTL5_uc003iqi.2_Silent_p.L374L|FSTL5_uc010iqv.2_Silent_p.L374L	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	375	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCCATTCTTCAACCAGCCAA	0.443													0	0	0	0.009718	0	42	59										T	162463736	C	T	162463736	2	4	89	1	0	0	0	0	0	0	0	1	6080	825	29	1		1	FSTL5	4	162463736	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7305666	162463736	28690540	122	26700										
WDR17	116966	broad.mit.edu	37	chr4	177098267	177098267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaattgaatatctttctgagGaattggatgcatggagagct	11	4	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:177098267G>A	uc003iuj.2	+	29	3781	c.3625G>A	c.(3625-3627)GAA>AAA	p.E1209K	WDR17_uc003iuk.2_Missense_Mutation_p.E1185K|WDR17_uc003ium.3_Missense_Mutation_p.E1170K|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.E420K	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1209										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TCTTTCTGAGGAATTGGATGC	0.363													0	0	0	0.021523	0	21	48										A	177098267	G	A	177098267	3	1	89	1	0	0	0	0	1	0	0	0	17274	1175	41	1	3735	1	WDR17	4	177098267	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	14634531	177098267	14056009	123	26701										
SNX25	83891	broad.mit.edu	37	chr4	186188167	186188167	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgagtaatccagattacattAaccaaatgctgcttgcccag	7	10	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:186188167A>G	uc003ixh.2	+	5	646	c.457A>G	c.(457-459)AAC>GAC	p.N153D		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	153	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AGATTACATTAACCAAATGCT	0.453													0	0	0	0.006999	0	37	65										G	186188167	A	G	186188167	3	3	89	1	0	0	0	0	1	0	0	0	14896	362	13	5	471	5	SNX25	4	186188167	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	9089900	186188167	4966109	124	26702										
TRIML1	339976	broad.mit.edu	37	chr4	189068457	189068457	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gccctcaggcctatcttttcCccctgcctcccaaatgaggg	8	17	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:189068457C>A	uc003izm.1	+	6	1453	c.1338C>A	c.(1336-1338)TCC>TCA	p.S446S	TRIML1_uc003izn.1_Silent_p.S170S	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	446	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CTATCTTTTCCCCCTGCCTCC	0.562													1	0	8.69298e-16	0.006999	1.00933e-15	40	90										A	189068457	C	A	189068457	2	1	89	1	0	0	0	0	0	0	0	1	16547	610	22	4		4	TRIML1	4	189068457	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2880290	189068457	2085819	125	26703										
SLC12A7	10723	broad.mit.edu	37	chr5	1064299	1064299	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gccgaagcgctcctggttttGcggaaacgagtcgacgttct	13	11	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:1064299G>T	uc003jbu.2	-	19	2572	c.2506C>A	c.(2506-2508)CAA>AAA	p.Q836K		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	836					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TCCTGGTTTTGCGGAAACGAG	0.672													1	0	2.23348e-06	0.004007	2.31698e-06	15	29										T	1064299	G	T	1064299	3	4	89	1	0	0	0	0	1	0	0	0	14388	1328	46	4	769	4	SLC12A7	5	1064299	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		1064299	179850961	126	26704										
SLC6A3	6531	broad.mit.edu	37	chr5	1441523	1441523	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccagcggccccttccctgttGaactggccgagggccagctc	12	17	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:1441523G>T	uc003jck.2	-	3	490	c.369C>A	c.(367-369)TTC>TTA	p.F123L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	123					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CTTCCCTGTTGAACTGGCCGA	0.587													1	0	6.50621e-10	0.013726	7.05263e-10	33	23										T	1441523	G	T	1441523	3	4	89	1	0	0	0	0	1	0	0	0	14685	1281	45	3	1545	3	SLC6A3	5	1441523	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	377224	1441523	179473737	127	26705										
CCT5	22948	broad.mit.edu	37	chr5	10254301	10254301	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtagcaaatacaatgagaacAtcacttggaccaaatggtaa	8	7	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:10254301A>C	uc003jeq.2	+	2	321	c.150A>C	c.(148-150)ACA>ACC	p.T50T	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Silent_p.T50T|CCT5_uc010its.2_Silent_p.T50T|CCT5_uc011cmr.1_Silent_p.T50T|CCT5_uc011cms.1_Silent_p.T12T|CCT5_uc011cmt.1_Silent_p.T12T	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	50					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						CAATGAGAACATCACTTGGAC	0.328													0	0	0	0.01892	0	22	33										C	10254301	A	C	10254301	2	2	89	1	0	0	0	0	0	0	0	1	2956	204	8	5		5	CCT5	5	10254301	Silent	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	8812778	10254301	170660959	128	26706										
CTNND2	1501	broad.mit.edu	37	chr5	11199772	11199772	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggatgcctccttgtctccttAtctgaaagagcaaaggacac	9	11	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:11199772A>C	uc003jfa.1	-	11	1908	c.1763T>G	c.(1762-1764)ATA>AGA	p.I588R	CTNND2_uc010itt.2_Missense_Mutation_p.I497R|CTNND2_uc011cmy.1_Missense_Mutation_p.I251R|CTNND2_uc011cmz.1_Missense_Mutation_p.I155R|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.I155R	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	588	ARM 3.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TTGTCTCCTTATCTGAAAGAG	0.448													0	0	0	0.007413	0	20	30										C	11199772	A	C	11199772	3	2	89	1	0	0	0	0	1	0	0	0	4020	463	16	5	1962	5	CTNND2	5	11199772	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	945471	11199772	169715488	129	26707										
FBXL7	23194	broad.mit.edu	37	chr5	15928355	15928355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggactatccgcctgacgggcGagaccatcaacgtggaccgc	13	14	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:15928355G>A	uc003jfn.1	+	3	965	c.484G>A	c.(484-486)GAG>AAG	p.E162K		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	162					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CCTGACGGGCGAGACCATCAA	0.662													0	0	0	0.001168	0	6	13										A	15928355	G	A	15928355	3	1	89	1	0	0	0	0	1	0	0	0	5724	1059	37	1	494	1	FBXL7	5	15928355	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4728583	15928355	164986905	130	26708										
ADAMTS12	81792	broad.mit.edu	37	chr5	33576746	33576746	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agggttgcgggaagatgacaAgccagaaccacttgttgttg	14	7	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:33576746A>T	uc003jia.1	-	19	3548	c.3385T>A	c.(3385-3387)TTG>ATG	p.L1129M	ADAMTS12_uc010iuq.1_Missense_Mutation_p.L1044M	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1129	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GAAGATGACAAGCCAGAACCA	0.483										HNSCC(64;0.19)			0	0	0	0.007291	0	30	68										T	33576746	A	T	33576746	3	4	89	1	0	0	0	0	1	0	0	0	257	69	3	5	1423	5	ADAMTS12	5	33576746	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	17648391	33576746	147338514	131	26709										
SPEF2	79925	broad.mit.edu	37	chr5	35700720	35700720	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cacagaagtggaaagaaaaaAagcacaaaaatccacattgg	8	7	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:35700720A>C	uc003jjo.2	+	16	2375	c.2264A>C	c.(2263-2265)AAA>ACA	p.K755T	SPEF2_uc003jjq.3_Missense_Mutation_p.K750T|SPEF2_uc003jjp.1_Missense_Mutation_p.K241T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	755	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAAAGAAAAAAAGCACAAAAA	0.383													0	0	0	0.016723	0	12	38										C	35700720	A	C	35700720	3	2	89	1	0	0	0	0	1	0	0	0	15034	14	1	5	2347	5	SPEF2	5	35700720	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	2123974	35700720	145214540	132	26710										
ITGA1	3672	broad.mit.edu	37	chr5	52183724	52183724	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tattgtgacagatggagagtCtcatgacaatcatcgactga	10	7	2	5			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:52183724C>G	uc003jou.2	+	8	903	c.851C>G	c.(850-852)TCT>TGT	p.S284C	ITGA1_uc003jov.2_RNA	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	284	Extracellular (Potential).|VWFA.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GATGGAGAGTCTCATGACAAT	0.423													0	0	0	0.013537	0	11	49										G	52183724	C	G	52183724	3	3	89	1	0	0	0	0	1	0	0	0	7872	913	32	1	881	1	ITGA1	5	52183724	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	16483004	52183724	128731536	133	26711										
DMXL1	1657	broad.mit.edu	37	chr5	118485427	118485427	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaagaaaactgcattcgatcCttcagtggatatggaagatt	9	6	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:118485427C>A	uc003ksd.2	+	18	4086	c.3905C>A	c.(3904-3906)CCT>CAT	p.P1302H	DMXL1_uc010jcl.1_Missense_Mutation_p.P1302H	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1302										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GCATTCGATCCTTCAGTGGAT	0.438													1	0	2.76378e-25	0.01441	3.50206e-25	51	20										A	118485427	C	A	118485427	3	1	89	1	0	0	0	0	1	0	0	0	4594	681	24	4	3975	4	DMXL1	5	118485427	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	66301703	118485427	62429833	134	26712										
MEGF10	84466	broad.mit.edu	37	chr5	126754869	126754869	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgggataaactgttcctctCgctgtggctgtaaaaatgat	10	7	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:126754869C>T	uc003kuh.3	+	12	1725	c.1363C>T	c.(1363-1365)CGC>TGC	p.R455C	MEGF10_uc010jdc.1_Missense_Mutation_p.R455C|MEGF10_uc010jdd.1_Missense_Mutation_p.R455C|MEGF10_uc003kui.3_Missense_Mutation_p.R455C	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	455	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 8.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CTGTTCCTCTCGCTGTGGCTG	0.458													0	0	0	0.021523	0	23	107										T	126754869	C	T	126754869	3	4	89	1	0	0	0	0	1	0	0	0	9460	884	31	1	1401	1	MEGF10	5	126754869	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	8269442	126754869	54160391	135	26713										
C5orf56	441108	broad.mit.edu	37	chr5	131821922	131821922	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagacagtcaagcaggcaggCcaggccccaggagcaccaac	12	15	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:131821922C>A	uc010jds.1	+	4	258	c.83C>A	c.(82-84)GCC>GAC	p.A28D	IRF1_uc003kxd.2_Intron|IRF1_uc003kxa.2_Intron|IRF1_uc003kxb.2_Intron|IRF1_uc010jdt.1_Intron			Q8N8D9	CE056_HUMAN	Homo sapiens full length insert cDNA clone ZA99C08.	Error:Variant_position_missing_in_Q8N8D9_after_alignment											0						AGCAGGCAGGCCAGGCCCCAG	0.557													1	0	2.32078e-09	0.003163	2.49619e-09	14	70										A	131821922	C	A	131821922	3	1	89	1	0	0	0	0	1	0	0	0	2312	754	26	4		4	C5orf56	5	131821922	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5067053	131821922	49093338	136	26714										
PCDHA1	56147	broad.mit.edu	37	chr5	140167598	140167598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcgagtgggtggcactattGgtgcagtcagtgagctggtg	17	7	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140167598G>A	uc003lhb.2	+	1	1723	c.1723G>A	c.(1723-1725)GGT>AGT	p.G575S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.G575S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	575	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACTATTGGTGCAGTCAG	0.672													0	0	0	0.01441	0	91	44										A	140167598	G	A	140167598	3	1	89	1	0	0	0	0	1	0	0	0	11519	1348	47	2	1725	2	PCDHA1	5	140167598	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8345676	140167598	40747662	137	26715										
PCDHA6	56142	broad.mit.edu	37	chr5	140209725	140209725	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaggcgtcatcacgggcgtcGgtgggcgccgcgggcccaga	18	13	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140209725G>A	uc003lho.2	+	1	2076	c.2049G>A	c.(2047-2049)TCG>TCA	p.S683S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S683S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	683	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGGCGTCGGTGGGCGCCG	0.667													0	0	0	0.01441	0	80	30										A	140209725	G	A	140209725	2	1	89	1	0	0	0	0	0	0	0	1	11528	1103	39	2		2	PCDHA6	5	140209725	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	42127	140209725	40705535	138	26716										
PCDHGA6	56109	broad.mit.edu	37	chr5	140755960	140755960	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgtaagagtcatctgattttCccccagcccaactatgccga	7	14	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140755960C>A	uc003ljy.1	+	1	2310	c.2310C>A	c.(2308-2310)TTC>TTA	p.F770L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.F770L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	770	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGATTTTCCCCCAGCCCA	0.517													1	0	3.89792e-41	0.01441	5.3416e-41	80	30										A	140755960	C	A	140755960	3	1	89	1	0	0	0	0	1	0	0	0	11558	854	30	3	2312	3	PCDHGA6	5	140755960	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	546235	140755960	40159300	139	26717										
FAT2	2196	broad.mit.edu	37	chr5	150925116	150925116	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atctctgacatgaatgatgaCttgggcaggtctgggtgcaa	13	7	2	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:150925116C>G	uc003lue.3	-	9	5585	c.5572G>C	c.(5572-5574)GTC>CTC	p.V1858L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1858	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAATGATGACTTGGGCAGGT	0.463													0	0	0	0.00499	0	17	66										G	150925116	C	G	150925116	3	3	89	1	0	0	0	0	1	0	0	0	5690	565	20	4	7537	4	FAT2	5	150925116	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	10169156	150925116	29990144	140	26718										
FAT2	2196	broad.mit.edu	37	chr5	150945387	150945387	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgcacctggccctggtgcaCgaaggaggcaaagtggggag	17	10	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:150945387C>A	uc003lue.3	-	1	3119	c.3106G>T	c.(3106-3108)GTG>TTG	p.V1036L	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.V1036L	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1036	Cadherin 9.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCTGGTGCACGAAGGAGGCA	0.602													1	0	2.17888e-05	0.006214	2.23526e-05	9	44										A	150945387	C	A	150945387	3	1	89	1	0	0	0	0	1	0	0	0	5690	536	19	4	10035	4	FAT2	5	150945387	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	20271	150945387	29969873	141	26719										
KIF4B	285643	broad.mit.edu	37	chr5	154393911	154393911	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaagctcaaataaatatacgGgaggatcctaaggaaggcat	10	6	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:154393911G>T	uc010jih.1	+	1	652	c.492G>T	c.(490-492)CGG>CGT	p.R164R		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	164	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAAATATACGGGAGGATCCTA	0.388													1	0	2.89027e-11	0.014323	3.20179e-11	19	124										T	154393911	G	T	154393911	2	4	89	1	0	0	0	0	0	0	0	1	8304	1219	43	4		4	KIF4B	5	154393911	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3448524	154393911	26521349	142	26720										
DOCK2	1794	broad.mit.edu	37	chr5	169101351	169101351	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagtccatgatgtacgatctGatggagtggaggtcccagct	13	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:169101351G>C	uc003maf.2	+	6	452	c.372G>C	c.(370-372)CTG>CTC	p.L124L	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	124					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTACGATCTGATGGAGTGGA	0.478													0	0	0	0.01441	0	50	23										C	169101351	G	C	169101351	2	2	89	1	0	0	0	0	0	0	0	1	4687	1277	45	1		1	DOCK2	5	169101351	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	14707440	169101351	11813909	143	26721										
SLC34A1	6569	broad.mit.edu	37	chr5	176815166	176815166	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgctcaagatcatcacagaGcccttcacgaagctcatcat	6	14	6	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:176815166G>T	uc003mgk.3	+	7	917	c.816G>T	c.(814-816)GAG>GAT	p.E272D		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	272	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCATCACAGAGCCCTTCACGA	0.597													1	0	7.63091e-17	0.007835	9.01097e-17	41	13										T	176815166	G	T	176815166	3	4	89	1	0	0	0	0	1	0	0	0	14567	962	34	4	838	4	SLC34A1	5	176815166	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7713815	176815166	4100094	144	26722										
GRM6	2916	broad.mit.edu	37	chr5	178410002	178410002	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggtgaagccgatgggcttgGcctcgttgaaggtctcgggc	17	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:178410002G>A	uc003mjr.2	-	9	2524	c.2345C>T	c.(2344-2346)GCC>GTC	p.A782V	GRM6_uc003mjq.2_Missense_Mutation_p.A185V	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	782	Cytoplasmic (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GATGGGCTTGGCCTCGTTGAA	0.587													0	0	0	0.01441	0	78	26										A	178410002	G	A	178410002	3	1	89	1	0	0	0	0	1	0	0	0	6801	1203	42	2	296	2	GRM6	5	178410002	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1594836	178410002	2505258	145	26723										
HUS1B	135458	broad.mit.edu	37	chr6	656803	656803	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagcctggcctcgtggaggcCgccggaacccgcggggccga	17	16	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:656803C>G	uc003mtg.2	-	1	162	c.142G>C	c.(142-144)GGC>CGC	p.G48R	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	48											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		TCGTGGAGGCCGCCGGAACCC	0.667													0	0	0	0.020292	0	14	7										G	656803	C	G	656803	3	3	89	1	0	0	0	0	1	0	0	0	7460	652	23	4	698	4	HUS1B	6	656803	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		656803	170458264	146	26724										
TUBB2A	7280	broad.mit.edu	37	chr6	3154784	3154784	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccccgtaggtgggggtggtCagcttcagggtgcggaagca	18	9	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:3154784C>G	uc003mvc.2	-	4	737	c.651G>C	c.(649-651)CTG>CTC	p.L217L	TUBB2A_uc003mvb.2_Silent_p.L210L|TUBB2A_uc003mvd.2_Silent_p.L180L	NM_001069	NP_001060	Q13885	TBB2A_HUMAN	tubulin, beta 2	217					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			skin(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGGGGGTGGTCAGCTTCAGGG	0.612													0	0	0	0.01441	0	49	71										G	3154784	C	G	3154784	2	3	89	1	0	0	0	0	0	0	0	1	16751	813	29	1		1	TUBB2A	6	3154784	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2497981	3154784	167960283	147	26725										
RANBP9	10048	broad.mit.edu	37	chr6	13644837	13644837	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taggaaatcgatctatctgtGcctggattttggttctccac	9	9	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:13644837G>A	uc003nbb.2	-	6	1111	c.1052C>T	c.(1051-1053)GCA>GTA	p.A351V	RANBP9_uc003nba.2_Missense_Mutation_p.A10V	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	351					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATCTATCTGTGCCTGGATTTT	0.413													0	0	0	0.01441	0	73	90										A	13644837	G	A	13644837	3	1	89	1	0	0	0	0	1	0	0	0	13032	1319	46	2	1173	2	RANBP9	6	13644837	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	10490053	13644837	157470230	148	26726										
C6orf62	81688	broad.mit.edu	37	chr6	24716501	24716501	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatattttcttcataattatTtgtcatgactggtataacct	5	6	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:24716501T>G	uc003nel.2	-	2	688	c.181A>C	c.(181-183)AAT>CAT	p.N61H		NM_030939	NP_112201	Q9GZU0	CF062_HUMAN	hypothetical protein LOC81688	61						intracellular					0						TCATAATTATTTGTCATGACT	0.398													0	0	0	0.013726	0	34	34										G	24716501	T	G	24716501	3	3	89	1	0	0	0	0	1	0	0	0	2368	1841	64	5	524	5	C6orf62	6	24716501	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	11071664	24716501	146398566	149	26727										
HIST1H2BB	3018	broad.mit.edu	37	chr6	26043564	26043564	+	Frame_Shift_Del	DEL	C	C	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcggacacagcatgcttagCcagctccccaggcagcagca							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:26043564delC	uc003nfu.2	-	1	322	c.322delG	c.(322-324)GCTfs	p.A108fs	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	108					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCATGCTTAGCCAGCTCCCCA	0.552																		49	53	---	---								-	26043564	C	-	26043564	7	5	89	1	0	1	0	1	0	0	0	0	7141	739	26	0	62	0	HIST1H2BB	6	26043564	Frame_Shift_Del	DEL	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1327063	26043564	145071503	150	26728										
PPP1R10	5514	broad.mit.edu	37	chr6	30571979	30571979	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcaaatgcatgtcggtctgaCagtatctctcgcttagccgc	9	12	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:30571979C>A	uc003nqn.1	-	14	1866	c.1314G>T	c.(1312-1314)CTG>CTT	p.L438L	PPP1R10_uc010jsc.1_Silent_p.L92L	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	438	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GTCGGTCTGACAGTATCTCTC	0.542													1	0	9.04393e-38	0.01441	1.23024e-37	68	72										A	30571979	C	A	30571979	2	1	89	1	0	0	0	0	0	0	0	1	12352	465	17	4		4	PPP1R10	6	30571979	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4528415	30571979	140543088	151	26729										
TNXB	7148	broad.mit.edu	37	chr6	31978813	31978813	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cacctgcacactctgaggctCccctgaaaacgttggggatc	10	14	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:31978813C>T	uc011dpc.1	-	4	1585	c.676G>A	c.(676-678)GAG>AAG	p.E226K	STK19_uc003nza.2_5'Flank|STK19_uc003nzb.2_5'Flank	NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	3842	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTCTGAGGCTCCCCTGAAAAC	0.637													0	0	0	0.01441	0	51	48										T	31978813	C	T	31978813	3	4	89	1	0	0	0	0	1	0	0	0	16343	864	30	1	1296	1	TNXB	6	31978813	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1406834	31978813	139136254	152	26730										
RGL2	5863	broad.mit.edu	37	chr6	33262770	33262771	+	Frame_Shift_Ins	INS	-	-	A													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	caccccaccccgggagccagINSacctcggggccttcttggag							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:33262770_33262771insA	uc003odv.2	-	10	1394_1395	c.1261_1262insT	c.(1261-1263)TCTfs	p.S421fs	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Frame_Shift_Ins_p.S339fs|RGL2_uc011drb.1_Frame_Shift_Ins_p.S339fs	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	421	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CCGGGAGCCAGACCTCGGGGCC	0.589																		8	5	---	---								A	33262771	-	A	33262770	7	5	89	1	0	1	1	0	0	0	0	0	13277	942	33	0	1107	0	RGL2	6	33262770	Frame_Shift_Ins	INS	-	TCGA-FJ-A3ZE-01A-11D-A23M-08	1283957	33262770	137852297	153	26731										
MDFI	4188	broad.mit.edu	37	chr6	41621214	41621214	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagtgtgccgactgcgacctGccctgcgacctggactgcgg	15	14	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:41621214G>T	uc003oqp.3	+	6	971	c.642G>T	c.(640-642)CTG>CTT	p.L214L	MDFI_uc003oqq.3_Silent_p.L214L|MDFI_uc010jxn.2_Silent_p.L214L	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	214	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTGCGACCTGCCCTGCGACC	0.657													1	0	3.46703e-50	0.01441	4.8714e-50	97	112										T	41621214	G	T	41621214	2	4	89	1	0	0	0	0	0	0	0	1	9404	1306	46	4		4	MDFI	6	41621214	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8358444	41621214	129493853	154	26732										
PRPH2	5961	broad.mit.edu	37	chr6	42689673	42689673	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtacttcatgccgttcttgaGcccttggcccagggtgttct	11	12	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:42689673G>T	uc003osk.2	-	1	686	c.400C>A	c.(400-402)CTC>ATC	p.L134I		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	134	Lumenal (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CCGTTCTTGAGCCCTTGGCCC	0.542													1	0	1.30293e-26	0.015359	1.66236e-26	33	43										T	42689673	G	T	42689673	3	4	89	1	0	0	0	0	1	0	0	0	12577	971	34	4	652	4	PRPH2	6	42689673	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1068459	42689673	128425394	155	26733										
COL19A1	1310	broad.mit.edu	37	chr6	70890380	70890380	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaggacctgttggagatataGgtttccctggaccagaagga	14	7	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:70890380G>T	uc003pfc.1	+	44	2857	c.2740G>T	c.(2740-2742)GGT>TGT	p.G914C		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	914	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TGGAGATATAGGTTTCCCTGG	0.398													1	0	2.56662e-36	0.013114	3.47432e-36	40	46										T	70890380	G	T	70890380	3	4	89	1	0	0	0	0	1	0	0	0	3676	1000	35	4	2910	4	COL19A1	6	70890380	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	28200707	70890380	100224687	156	26734										
IMPG1	3617	broad.mit.edu	37	chr6	76751757	76751757	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctcatagttgacattttgtAcattttttcagtactttcag	5	7	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:76751757A>G	uc003pik.1	-	2	284	c.154T>C	c.(154-156)TAC>CAC	p.Y52H		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	52					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GACATTTTGTACATTTTTTCA	0.358													0	0	0	0.01441	0	59	55										G	76751757	A	G	76751757	3	3	89	1	0	0	0	0	1	0	0	0	7728	391	14	5	2303	5	IMPG1	6	76751757	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	5861377	76751757	94363310	157	26735										
SNX14	57231	broad.mit.edu	37	chr6	86227735	86227735	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagttactcacctctttcatTagttttccaggaacagattt	5	10	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:86227735T>C	uc003pkr.2	-	22	2332	c.2139A>G	c.(2137-2139)CTA>CTG	p.L713L	SNX14_uc003pkp.2_Silent_p.L576L|SNX14_uc003pkq.2_Silent_p.L319L|SNX14_uc011dzg.1_Silent_p.L661L|SNX14_uc003pks.2_Silent_p.L660L|SNX14_uc003pkt.2_Silent_p.L704L	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	713					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CCTCTTTCATTAGTTTTCCAG	0.254													0	0	0	0.01441	0	45	55										C	86227735	T	C	86227735	2	2	89	1	0	0	0	0	0	0	0	1	14885	1741	61	5		5	SNX14	6	86227735	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	9475978	86227735	84887332	158	26736										
SFRS13B	135295	broad.mit.edu	37	chr6	89808433	89808433	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggatcttgctattgagtcaGaatgtcttccatgtgatctt	10	7	4	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:89808433G>A	uc003pmy.3	-	5	844	c.650C>T	c.(649-651)TCT>TTT	p.S217F		NM_080743	NP_542781	Q8WXF0	SRS12_HUMAN	serine-arginine repressor protein	217	Arg/Ser-rich (RS domain).				assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding				0						TATTGAGTCAGAATGTCTTCC	0.398													0	0	0	0.01441	0	76	80										A	89808433	G	A	89808433	3	1	89	1	0	0	0	0	1	0	0	0	14169	942	33	1	139	1	SFRS13B	6	89808433	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3580698	89808433	81306634	159	26737										
GABRR1	2569	broad.mit.edu	37	chr6	89910940	89910940	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcagaagctgttctgactttGtcagaggcgatttggtgatg	13	6	3	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:89910940G>T	uc003pna.2	-	3	673	c.218C>A	c.(217-219)ACA>AAA	p.T73K	GABRR1_uc011dzv.1_Missense_Mutation_p.T50K	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	73	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TTCTGACTTTGTCAGAGGCGA	0.473													1	0	2.25582e-47	0.01441	3.12214e-47	73	105										T	89910940	G	T	89910940	3	4	89	1	0	0	0	0	1	0	0	0	6176	1377	48	4	1253	4	GABRR1	6	89910940	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	102507	89910940	81204127	160	26738										
BACH2	60468	broad.mit.edu	37	chr6	90661238	90661238	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccttctctgctacggggatgGcggcggcctcaaagctgatg	14	12	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:90661238G>T	uc011eab.1	-	7	1396	c.587C>A	c.(586-588)GCC>GAC	p.A196D	BACH2_uc003pnw.2_Missense_Mutation_p.A196D|BACH2_uc010kch.2_Missense_Mutation_p.A196D	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	196						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TACGGGGATGGCGGCGGCCTC	0.602													1	0	1.86277e-20	0.01441	2.26719e-20	53	57										T	90661238	G	T	90661238	3	4	89	1	0	0	0	0	1	0	0	0	1284	1203	42	4	1950	4	BACH2	6	90661238	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	750298	90661238	80453829	161	26739										
GRIK2	2898	broad.mit.edu	37	chr6	102372594	102372594	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttggagctctcatgcagcaaGgtatacgattcagcctgcta	10	10	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:102372594G>A	uc003pqp.3	+	12	2116	c.1867G>A	c.(1867-1869)GGT>AGT	p.G623S	GRIK2_uc003pqo.3_Missense_Mutation_p.G623S|GRIK2_uc010kcw.2_Missense_Mutation_p.G623S	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	623	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CATGCAGCAAGGTATACGATT	0.498													0	0	0	0.004007	0	14	46										A	102372594	G	A	102372594	3	1	89	1	0	0	0	0	1	0	0	0	6774	1014	35	2	1913	2	GRIK2	6	102372594	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11711356	102372594	68742473	162	26740										
LAMA2	3908	broad.mit.edu	37	chr6	129636975	129636975	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgggaagaaacaggtttctcTacatataatcctcaagtgat	8	8	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:129636975T>C	uc003qbn.2	+	26	3909	c.3804T>C	c.(3802-3804)TCT>TCC	p.S1268S	LAMA2_uc003qbo.2_Silent_p.S1268S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1268	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAGGTTTCTCTACATATAATC	0.438													0	0	0	0.01441	0	62	58										C	129636975	T	C	129636975	2	2	89	1	0	0	0	0	0	0	0	1	8606	1509	53	5		5	LAMA2	6	129636975	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	27264381	129636975	41478092	163	26741										
PEX3	8504	broad.mit.edu	37	chr6	143784110	143784110	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcagcaactgaattccgagaGcctcacagctctgctaaaaa	8	12	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:143784110G>A	uc003qjl.2	+	3	525	c.263G>A	c.(262-264)AGC>AAC	p.S88N	PEX3_uc011edx.1_Missense_Mutation_p.S88N	NM_003630	NP_003621	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	88	Peroxisomal (Potential).				protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		AATTCCGAGAGCCTCACAGCT	0.358													0	0	0	0.00874	0	38	33										A	143784110	G	A	143784110	3	1	89	1	0	0	0	0	1	0	0	0	11747	971	34	2	273	2	PEX3	6	143784110	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	14147135	143784110	27330957	164	26742										
PSMB1	5689	broad.mit.edu	37	chr6	170862291	170862291	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtgcggttccatccccaagtCtctgccaggagccgaataca	10	14	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:170862291C>G	uc011ehe.1	-	1	127	c.40G>C	c.(40-42)GAC>CAC	p.D14H	PSMB1_uc003qxq.2_RNA|PSMB1_uc003qxr.2_5'Flank|TBP_uc003qxt.2_5'Flank|TBP_uc003qxu.2_5'Flank|TBP_uc011ehf.1_5'Flank	NM_002793	NP_002784	P20618	PSB1_HUMAN	proteasome beta 1 subunit precursor	14					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	ATCCCCAAGTCTCTGCCAGGA	0.597													0	0	0	0.006214	0	7	19										G	170862291	C	G	170862291	3	3	89	1	0	0	0	0	1	0	0	0	12674	913	32	1	709	1	PSMB1	6	170862291	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	27078181	170862291	252776	165	26743										
EIF3B	8662	broad.mit.edu	37	chr7	2404033	2404033	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acagagacgtatgtgcgttgGtctcctaagggcacctacct	11	11	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:2404033G>A	uc003slx.2	+	6	1109	c.1026G>A	c.(1024-1026)TGG>TGA	p.W342*	EIF3B_uc003sly.2_Nonsense_Mutation_p.W342*|EIF3B_uc003slz.1_Nonsense_Mutation_p.W303*|EIF3B_uc003sma.2_Nonsense_Mutation_p.W70*	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	342	Sufficient for interaction with EIF3E.|WD 1.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		ATGTGCGTTGGTCTCCTAAGG	0.463													0	0	0	0.01441	0	97	95										A	2404033	G	A	2404033	4	1	89	1	0	0	0	0	0	1	0	0	5013	1270	44	2	1048	2	EIF3B	7	2404033	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		2404033	156734630	166	26744										
SDK1	221935	broad.mit.edu	37	chr7	4153858	4153858	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgcaggccttcaacgccgtcGgggctgggccgtggagcgag	18	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:4153858G>T	uc003smx.2	+	25	3914	c.3775G>T	c.(3775-3777)GGG>TGG	p.G1259W	SDK1_uc010kso.2_Missense_Mutation_p.G535W	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1259	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAACGCCGTCGGGGCTGGGCC	0.642													1	0	2.44723e-14	0.004656	2.81204e-14	26	21										T	4153858	G	T	4153858	3	4	89	1	0	0	0	0	1	0	0	0	13968	1116	39	4	3873	4	SDK1	7	4153858	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1749825	4153858	154984805	167	26745										
RBAK	57786	broad.mit.edu	37	chr7	5103373	5103373	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agagaatccaagaaaacgaaGacaaacattcaaggcaagct	8	8	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:5103373G>A	uc010kss.1	+	6	610	c.286G>A	c.(286-288)GAC>AAC	p.D96N	LOC389458_uc003snr.2_Missense_Mutation_p.D96N|RBAK_uc003sns.1_Missense_Mutation_p.D96N	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	96					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AGAAAACGAAGACAAACATTC	0.363													0	0	0	0.012319	0	19	28										A	5103373	G	A	5103373	3	1	89	1	0	0	0	0	1	0	0	0	13100	942	33	1	300	1	RBAK	7	5103373	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	949515	5103373	154035290	168	26746										
MIOS	54468	broad.mit.edu	37	chr7	7636000	7636000	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagtggctcaccaacgaaatCtaaagtcacaagttgtcctg	9	10	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:7636000C>A	uc003srf.2	+	11	2617	c.2309C>A	c.(2308-2310)TCT>TAT	p.S770Y	MIOS_uc003srg.2_Missense_Mutation_p.S305Y|MIOS_uc010ktq.2_Missense_Mutation_p.S165Y	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	770											0						CCAACGAAATCTAAAGTCACA	0.468													1	0	1.52009e-12	0.003163	1.70779e-12	16	134										A	7636000	C	A	7636000	3	1	89	1	0	0	0	0	1	0	0	0	9589	913	32	3	2339	3	MIOS	7	7636000	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2532627	7636000	151502663	169	26747										
AHR	196	broad.mit.edu	37	chr7	17379440	17379440	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccaattcgtgcctttcaattGtccacagcaagacccacaac	5	15	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:17379440G>T	uc011jxz.1	+	10	2604	c.1991G>T	c.(1990-1992)TGT>TTT	p.C664F	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	664					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CCTTTCAATTGTCCACAGCAA	0.408													1	0	6.71967e-41	0.01441	9.18575e-41	81	78										T	17379440	G	T	17379440	3	4	89	1	0	0	0	0	1	0	0	0	416	1377	48	4	2029	4	AHR	7	17379440	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	9743440	17379440	141759223	170	26748										
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26236509	26236509	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccagactgcctatcagtaatTatctcaatggtatcaatttt	5	9	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:26236509T>C	uc003sxr.3	-	5	645	c.429A>G	c.(427-429)ATA>ATG	p.I143M	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.I131M	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	143	RRM 2.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TATCAGTAATTATCTCAATGG	0.368			T	ETV1	prostate								0	0	0	0.01441	0	108	94										C	26236509	T	C	26236509	3	2	89	1	0	0	0	0	1	0	0	0	7259	1744	61	5	660	5	HNRNPA2B1	7	26236509	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	8857069	26236509	132902154	171	26749										
HECW1	23072	broad.mit.edu	37	chr7	43503285	43503285	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaacattcagcgaaccattgCaacagagaggtccgaagaag	10	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:43503285C>G	uc003tid.1	+	14	3283	c.2678C>G	c.(2677-2679)GCA>GGA	p.A893G	HECW1_uc011kbi.1_Missense_Mutation_p.A859G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	893	Potential.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CGAACCATTGCAACAGAGAGG	0.498													0	0	0	0.01441	0	51	73										G	43503285	C	G	43503285	3	3	89	1	0	0	0	0	1	0	0	0	7042	710	25	4	2724	4	HECW1	7	43503285	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	17266776	43503285	115635378	172	26750										
ADCY1	107	broad.mit.edu	37	chr7	45725689	45725689	+	Frame_Shift_Del	DEL	C	C	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	caccatgccctgctctgctgCctggtgggcaccctcccgct							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:45725689delC	uc003tne.3	+	13	2220	c.2202delC	c.(2200-2202)TGCfs	p.C734fs		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	734	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGCTCTGCTGCCTGGTGGGCA	0.622																		37	56	---	---								-	45725689	C	-	45725689	7	5	89	1	0	1	0	1	0	0	0	0	292	747	26	0	2252	0	ADCY1	7	45725689	Frame_Shift_Del	DEL	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2222404	45725689	113412974	173	26751										
WBSCR22	114049	broad.mit.edu	37	chr7	73101013	73101013	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatggctgggcgagcattggAgcttctttatctgccagaga	14	8	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:73101013A>G	uc003tyt.2	+	3	192	c.134A>G	c.(133-135)GAG>GGG	p.E45G	WBSCR22_uc010lbi.1_RNA|WBSCR22_uc003tyu.2_Missense_Mutation_p.E45G|WBSCR22_uc003tyv.2_Missense_Mutation_p.E7G|WBSCR22_uc003tyw.1_5'UTR	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	45						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CGAGCATTGGAGCTTCTTTAT	0.483													0	0	0	0.01441	0	86	113										G	73101013	A	G	73101013	3	3	89	1	0	0	0	0	1	0	0	0	17262	304	11	5	144	5	WBSCR22	7	73101013	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	27375324	73101013	86037650	174	26752										
SEMA3D	223117	broad.mit.edu	37	chr7	84628764	84628764	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttaagtagaaaactacgtggCtacagctctagggagctcat	10	8	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:84628764C>T	uc003uic.2	-	17	2366	c.2326G>A	c.(2326-2328)GCC>ACC	p.A776T	SEMA3D_uc010led.2_Missense_Mutation_p.A776T|SEMA3D_uc003uib.2_Missense_Mutation_p.A415T	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	776					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						AACTACGTGGCTACAGCTCTA	0.393													0	0	0	0.021523	0	26	43										T	84628764	C	T	84628764	3	4	89	1	0	0	0	0	1	0	0	0	14027	797	28	2	11	2	SEMA3D	7	84628764	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	11527751	84628764	74509899	175	26753										
ABCB1	5243	broad.mit.edu	37	chr7	87179515	87179515	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgtggggtcatagagcctcTgcatcagctggactgttgtg	14	9	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:87179515T>C	uc003uiz.1	-	13	1740	c.1322A>G	c.(1321-1323)CAG>CGG	p.Q441R	ABCB1_uc011khc.1_Missense_Mutation_p.Q377R	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	441	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATAGAGCCTCTGCATCAGCTG	0.552													0	0	0	0.009535	0	31	47										C	87179515	T	C	87179515	3	2	89	1	0	0	0	0	1	0	0	0	40	1580	55	5	2588	5	ABCB1	7	87179515	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	2550751	87179515	71959148	176	26754										
TRRAP	8295	broad.mit.edu	37	chr7	98487961	98487961	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatttttgcacaattagaatGtcacgtcatctcctcagtat	5	9	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:98487961G>A	uc003upp.2	+	4	363	c.154G>A	c.(154-156)GTC>ATC	p.V52I	TRRAP_uc011kis.1_Missense_Mutation_p.V52I	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	52					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CAATTAGAATGTCACGTCATC	0.328													0	0	0	0.016522	0	22	24										A	98487961	G	A	98487961	3	1	89	1	0	0	0	0	1	0	0	0	16598	1377	48	2	164	2	TRRAP	7	98487961	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11308446	98487961	60650702	177	26755										
SH2B2	10603	broad.mit.edu	37	chr7	101944428	101944428	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtggacattcaacgcgagggGgcgctgcgcttcatggtggc	17	10	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:101944428G>C	uc011kko.1	+	2	768	c.723G>C	c.(721-723)GGG>GGC	p.G241G		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	198	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						AACGCGAGGGGGCGCTGCGCT	0.746													0	0	0	0.00308	0	7	5										C	101944428	G	C	101944428	2	2	89	1	0	0	0	0	0	0	0	1	14228	1219	43	4		4	SH2B2	7	101944428	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3456467	101944428	57194235	178	26756										
RINT1	60561	broad.mit.edu	37	chr7	105190500	105190500	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aactattttcctccttccttAgccagaatggtacttggctc	6	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:105190500A>G	uc003vda.1	+	8	1228	c.997_splice	c.e8-2	p.P333_splice	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1						cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						CTCCTTCCTTAGCCAGAATGG	0.328													0	0	0	0.016522	0	23	30										G	105190500	A	G	105190500	5	3	89	1	0	0	0	0	0	0	1	0	13376	434	15	5	1025	5	RINT1	7	105190500	Splice_Site	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	3246072	105190500	53948163	179	26757										
CTTNBP2	83992	broad.mit.edu	37	chr7	117424464	117424464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggcctgccagccaggggggCaggaccaccactcattagca	14	14	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:117424464C>T	uc003vjf.2	-	5	2205	c.2113G>A	c.(2113-2115)GCC>ACC	p.A705T		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	705										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GCCAGGGGGGCAGGACCACCA	0.507													0	0	0	0.01441	0	79	66										T	117424464	C	T	117424464	3	4	89	1	0	0	0	0	1	0	0	0	4045	710	25	2	2954	2	CTTNBP2	7	117424464	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	12233964	117424464	41714199	180	26758										
SMO	6608	broad.mit.edu	37	chr7	128850354	128850354	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcacctgggtctggaccaaGgccacgctgctcatctggag	13	13	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:128850354G>A	uc003vor.2	+	9	1897	c.1617G>A	c.(1615-1617)AAG>AAA	p.K539K	SMO_uc003vos.2_Silent_p.K214K	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	539	Helical; Name=7; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						TCTGGACCAAGGCCACGCTGC	0.607			Mis		skin basal cell 						OREG0018305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	47	71										A	128850354	G	A	128850354	2	1	89	1	0	0	0	0	0	0	0	1	14800	991	35	2		2	SMO	7	128850354	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11425890	128850354	30288309	181	26759										
SLC13A4	26266	broad.mit.edu	37	chr7	135376027	135376027	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atggtcttctggaagtccttCcacgtgatgatgggctcggt	13	9	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:135376027C>G	uc003vta.2	-	13	2054	c.1365G>C	c.(1363-1365)TGG>TGC	p.W455C	SLC13A4_uc003vtb.2_Missense_Mutation_p.W456C|PL-5283_uc003vsz.3_Intron	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	455						integral to plasma membrane	sodium:sulfate symporter activity				0						GGAAGTCCTTCCACGTGATGA	0.498													0	0	0	0.013726	0	34	46										G	135376027	C	G	135376027	3	3	89	1	0	0	0	0	1	0	0	0	14394	856	30	1	531	1	SLC13A4	7	135376027	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6525673	135376027	23762636	182	26760										
MGAM	8972	broad.mit.edu	37	chr7	141747614	141747614	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccctcttggtcttatcattgCcctagatgagaacaaagaag	8	10	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:141747614C>A	uc003vwy.2	+	22	2582	c.2528C>A	c.(2527-2529)GCC>GAC	p.A843D		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	843	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTTATCATTGCCCTAGATGAG	0.438													1	0	3.27435e-08	0.020292	3.45488e-08	10	16										A	141747614	C	A	141747614	3	1	89	1	0	0	0	0	1	0	0	0	9541	739	26	4	2610	4	MGAM	7	141747614	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6371587	141747614	17391049	183	26761										
SSPO	23145	broad.mit.edu	37	chr7	149482090	149482090	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atggctgtgtctgtccaccaGgcacggtgctgctggtgagt	15	10	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:149482090G>A	uc010lpk.2	+	20	2878	c.2878G>A	c.(2878-2880)GGC>AGC	p.G960S	SSPO_uc010lpl.1_Silent_p.Q295Q	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	960					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGTCCACCAGGCACGGTGCT	0.627													0	0	0	0.012319	0	22	17										A	149482090	G	A	149482090	3	1	89	1	0	0	0	0	1	0	0	0	15188	991	35	2	2952	2	SSPO	7	149482090	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7734476	149482090	9656573	184	26762										
ASB10	136371	broad.mit.edu	37	chr7	150878038	150878038	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccccataccttggggagggcCcctggccagacacggacggc	14	16	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:150878038C>G	uc003wjm.1	-	3	1353	c.1227G>C	c.(1225-1227)GGG>GGC	p.G409G	ASB10_uc003wjl.1_Silent_p.G409G|ASB10_uc003wjn.1_Silent_p.G349G	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	364					intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGAGGGCCCCTGGCCAGA	0.682													0	0	0	0.003163	0	15	15										G	150878038	C	G	150878038	2	3	89	1	0	0	0	0	0	0	0	1	1014	610	22	4		4	ASB10	7	150878038	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1395948	150878038	8260625	185	26763										
PTPRN2	5799	broad.mit.edu	37	chr7	157874068	157874068	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggtcactgctggtccgagaaCcctggaagggataatttaaa	12	8	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:157874068C>A	uc003wno.2	-	11	1766	c.1645G>T	c.(1645-1647)GTT>TTT	p.V549F	PTPRN2_uc003wnp.2_Missense_Mutation_p.V532F|PTPRN2_uc003wnq.2_Missense_Mutation_p.V520F|PTPRN2_uc003wnr.2_Missense_Mutation_p.V511F|PTPRN2_uc011kwa.1_Missense_Mutation_p.V572F	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	549	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGTCCGAGAACCCTGGAAGGG	0.448													1	0	1.05386e-31	0.01441	1.40262e-31	49	44										A	157874068	C	A	157874068	3	1	89	1	0	0	0	0	1	0	0	0	12808	521	18	4	1454	4	PTPRN2	7	157874068	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6996030	157874068	1264595	186	26764										
VIPR2	7434	broad.mit.edu	37	chr7	158824638	158824638	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgcacacctacctggaacgaCccgaggcacagctcaaacag	9	16	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:158824638C>T	uc003woh.2	-	11	1278	c.1092G>A	c.(1090-1092)GGG>GGA	p.G364G	VIPR2_uc010lqx.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	364	Helical; Name=7; (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CCTGGAACGACCCGAGGCACA	0.607													0	0	0	0.01441	0	64	67										T	158824638	C	T	158824638	2	4	89	1	0	0	0	0	0	0	0	1	17167	494	18	2		2	VIPR2	7	158824638	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	950570	158824638	314025	187	26765										
DLGAP2	9228	broad.mit.edu	37	chr8	1497669	1497669	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagagcaacaacgacgtcaaGtgctcggcctgtgaggggtt	14	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:1497669G>C	uc003wpl.2	+	2	907	c.810G>C	c.(808-810)AAG>AAC	p.K270N	DLGAP2_uc003wpm.2_Missense_Mutation_p.K270N	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	349					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACGACGTCAAGTGCTCGGCCT	0.672													0	0	0	0.01441	0	65	7										C	1497669	G	C	1497669	3	2	89	1	0	0	0	0	1	0	0	0	4560	1020	36	4	812	4	DLGAP2	8	1497669	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		1497669	144866353	188	26766										
CSMD1	64478	broad.mit.edu	37	chr8	2944710	2944710	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggccgaccattcggtatccAggcttgcaaaaataatgcac	9	11	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:2944710A>T	uc011kwk.1	-	49	7776	c.7386T>A	c.(7384-7386)CCT>CCA	p.P2462P	CSMD1_uc011kwj.1_Silent_p.P1791P|CSMD1_uc010lrg.2_Silent_p.P530P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2462	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCGGTATCCAGGCTTGCAAA	0.522													0	0	0	0.01441	0	56	3										T	2944710	A	T	2944710	2	4	89	1	0	0	0	0	0	0	0	1	3944	175	7	5		5	CSMD1	8	2944710	Silent	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1447041	2944710	143419312	189	26767										
PTK2B	2185	broad.mit.edu	37	chr8	27297834	27297834	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggatgtcatcggggtgctgGagaaaggagaccggctgccc	17	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:27297834G>C	uc003xfn.1	+	26	2723	c.1915G>C	c.(1915-1917)GAG>CAG	p.E639Q	PTK2B_uc003xfo.1_Missense_Mutation_p.E639Q|PTK2B_uc003xfp.1_Missense_Mutation_p.E639Q|PTK2B_uc003xfq.1_Missense_Mutation_p.E639Q|PTK2B_uc003xfr.1_Missense_Mutation_p.E385Q	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	639	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CGGGGTGCTGGAGAAAGGAGA	0.607													0	0	0	0.008361	0	28	31										C	27297834	G	C	27297834	3	2	89	1	0	0	0	0	1	0	0	0	12763	1175	41	1	1993	1	PTK2B	8	27297834	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	24353124	27297834	119066188	190	26768										
CHRNA2	1135	broad.mit.edu	37	chr8	27327365	27327365	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggcgcgcccagcggttgtaGccccggaagaggtgtttgaa	17	10	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:27327365G>A	uc010lur.2	-	3	816	c.207C>T	c.(205-207)GGC>GGT	p.G69G	CHRNA2_uc011lal.1_Silent_p.G69G|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	69	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AGCGGTTGTAGCCCCGGAAGA	0.622													0	0	0	0.01441	0	77	9										A	27327365	G	A	27327365	2	1	89	1	0	0	0	0	0	0	0	1	3383	958	34	2		2	CHRNA2	8	27327365	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	29531	27327365	119036657	191	26769										
GPR124	25960	broad.mit.edu	37	chr8	37698748	37698748	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccaaggcgggcaacagcagGgcctccctggaggcagggga	17	13	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:37698748G>T	uc003xkj.2	+	19	3255	c.2892G>T	c.(2890-2892)AGG>AGT	p.R964S	GPR124_uc010lvy.2_Missense_Mutation_p.R747S	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	964	Cytoplasmic (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCAACAGCAGGGCCTCCCTGG	0.637													1	0	2.75727e-19	0.021022	3.30515e-19	38	155										T	37698748	G	T	37698748	3	4	89	1	0	0	0	0	1	0	0	0	6638	1223	43	4	2945	4	GPR124	8	37698748	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	10371383	37698748	108665274	192	26770										
BRF2	55290	broad.mit.edu	37	chr8	37702487	37702487	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgcaggcgggaggacgccgGgtagggcaggtccacatttg	18	10	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:37702487G>A	uc003xkk.2	-	4	891	c.781C>T	c.(781-783)CCG>TCG	p.P261S		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	261					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			GAGGACGCCGGGTAGGGCAGG	0.587													0	0	0	0.01441	0	141	30										A	37702487	G	A	37702487	3	1	89	1	0	0	0	0	1	0	0	0	1511	1232	43	2	482	2	BRF2	8	37702487	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3739	37702487	108661535	193	26771										
ADAM32	203102	broad.mit.edu	37	chr8	39103645	39103645	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agaatcaaggataattaaggCttcagcacatgtttgttcac	8	7	3	1	rs142346085	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:39103645C>T	uc003xmt.3	+	17	2107	c.1862C>T	c.(1861-1863)GCT>GTT	p.A621V	ADAM32_uc011lch.1_Missense_Mutation_p.A522V|ADAM32_uc003xmu.3_Missense_Mutation_p.A515V|ADAM32_uc003xmv.2_Missense_Mutation_p.A45V	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	621	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			ATAATTAAGGCTTCAGCACAT	0.368													0	0	0	0.013726	0	29	168										T	39103645	C	T	39103645	3	4	89	1	0	0	0	0	1	0	0	0	249	797	28	2	1928	2	ADAM32	8	39103645	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1401158	39103645	107260377	194	26772										
OPRK1	4986	broad.mit.edu	37	chr8	54142079	54142079	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagtaatagctggagagagcAgctgtgctgtgggaggtgct	17	5	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:54142079A>G	uc003xrh.1	-	3	1296	c.921T>C	c.(919-921)GCT>GCC	p.A307A	OPRK1_uc003xri.1_Silent_p.A307A|OPRK1_uc010lyc.1_Silent_p.A218A	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	307	Extracellular (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	TGGAGAGAGCAGCTGTGCTGT	0.527													0	0	0	0.004656	0	27	28										G	54142079	A	G	54142079	2	3	89	1	0	0	0	0	0	0	0	1	10885	175	7	5		5	OPRK1	8	54142079	Silent	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	15038434	54142079	92221943	195	26773										
TGS1	96764	broad.mit.edu	37	chr8	56717578	56717578	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggaaataccattcagtttgCcttaacaggaatgagaggta	10	6	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:56717578C>T	uc003xsj.3	+	10	2513	c.2126C>T	c.(2125-2127)GCC>GTC	p.A709V	TGS1_uc010lyh.2_Missense_Mutation_p.A613V	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	709	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ATTCAGTTTGCCTTAACAGGA	0.398													0	0	0	0.010771	0	42	56										T	56717578	C	T	56717578	3	4	89	1	0	0	0	0	1	0	0	0	15834	739	26	2	2164	2	TGS1	8	56717578	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2575499	56717578	89646444	196	26774										
CYP7A1	1581	broad.mit.edu	37	chr8	59409268	59409268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctccagatcatcaaaggtgGacaaagtgtcattgagaaac	9	8	4	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:59409268G>A	uc003xtm.3	-	3	866	c.803C>T	c.(802-804)TCC>TTC	p.S268F		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	268					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ATCAAAGGTGGACAAAGTGTC	0.498									Neonatal_Giant_Cell_Hepatitis				0	0	0	0.01441	0	101	132										A	59409268	G	A	59409268	3	1	89	1	0	0	0	0	1	0	0	0	4196	1174	41	1	727	1	CYP7A1	8	59409268	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2691690	59409268	86954754	197	26775										
EYA1	2138	broad.mit.edu	37	chr8	72211327	72211327	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctggtgatgccagatggcgGttcttgaagctggtaagtgg	17	6	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:72211327G>C	uc003xys.3	-	8	1068	c.781C>G	c.(781-783)CCG>GCG	p.P261A	EYA1_uc003xyr.3_Missense_Mutation_p.P256A|EYA1_uc003xyt.3_Missense_Mutation_p.P228A|EYA1_uc010lzf.2_Missense_Mutation_p.P188A|EYA1_uc003xyu.2_Missense_Mutation_p.P261A|EYA1_uc011lfe.1_Missense_Mutation_p.P255A|EYA1_uc003xyv.2_Missense_Mutation_p.P139A	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	261					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCAGATGGCGGTTCTTGAAGC	0.453													0	0	0	0.01441	0	51	78										C	72211327	G	C	72211327	3	2	89	1	0	0	0	0	1	0	0	0	5328	1261	44	4	1037	4	EYA1	8	72211327	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	12802059	72211327	74152695	198	26776										
CPNE3	8895	broad.mit.edu	37	chr8	87568404	87568404	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	accagacaagctatagttaaTgcctccaggctgcctatgtc	8	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:87568404T>G	uc003ydv.2	+	16	1491	c.1329T>G	c.(1327-1329)AAT>AAG	p.N443K	CPNE3_uc003ydw.1_Missense_Mutation_p.N159K	NM_003909	NP_003900	O75131	CPNE3_HUMAN	copine III	443	VWFA.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			ovary(1)|skin(1)	2						CTATAGTTAATGCCTCCAGGC	0.458													0	0	0	0.01441	0	62	63										G	87568404	T	G	87568404	3	3	89	1	0	0	0	0	1	0	0	0	3813	1461	51	5	1383	5	CPNE3	8	87568404	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	15357077	87568404	58795618	199	26777										
KCNS2	3788	broad.mit.edu	37	chr8	99441294	99441294	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agggcctggccaccatccctGcctgctggtggtgggctacc	14	15	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:99441294G>T	uc003yin.2	+	2	1437	c.1087G>T	c.(1087-1089)GCC>TCC	p.A363S		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	363						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CACCATCCCTGCCTGCTGGTG	0.602													1	0	4.88482e-21	0.01441	6.01126e-21	52	51										T	99441294	G	T	99441294	3	4	89	1	0	0	0	0	1	0	0	0	8089	1319	46	4	1089	4	KCNS2	8	99441294	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11872890	99441294	46922728	200	26778										
PKHD1L1	93035	broad.mit.edu	37	chr8	110489565	110489565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgttgtattctccaggattGctttcctgtacatccgccat	7	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:110489565G>A	uc003yne.2	+	53	9133	c.9029G>A	c.(9028-9030)TGC>TAC	p.C3010Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3010	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTCCAGGATTGCTTTCCTGTA	0.413										HNSCC(38;0.096)			0	0	0	0.008361	0	31	25										A	110489565	G	A	110489565	3	1	89	1	0	0	0	0	1	0	0	0	11972	1319	46	2	9239	2	PKHD1L1	8	110489565	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11048271	110489565	35874457	201	26779										
COL14A1	7373	broad.mit.edu	37	chr8	121279123	121279123	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cattccaccagcaaaagaagGtaaaagaataatagaataat	6	6	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:121279123G>A	uc003yox.2	+	25	3338	c.3073_splice	c.e25+1	p.V1025_splice	COL14A1_uc003yoy.2_Missense_Mutation_p.G703D	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCAAAAGAAGGTAAAAGAATA	0.353													0	0	0	0.01441	0	76	88										A	121279123	G	A	121279123	5	1	89	1	0	0	0	0	0	0	1	0	3671	1275	44	2	3168	2	COL14A1	8	121279123	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	10789558	121279123	25084899	202	26780										
SMARCA2	6595	broad.mit.edu	37	chr9	2115870	2115870	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcatcgggcagcagaacgagGtccgggtactgaggctctgt	16	10	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:2115870G>T	uc003zhc.2	+	25	3604	c.3505G>T	c.(3505-3507)GTC>TTC	p.V1169F	SMARCA2_uc003zhd.2_Missense_Mutation_p.V1169F|SMARCA2_uc010mha.2_Missense_Mutation_p.V1102F	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1169	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCAGAACGAGGTCCGGGTACT	0.572													1	0	6.94344e-10	0.006122	7.51191e-10	18	3										T	2115870	G	T	2115870	3	4	89	1	0	0	0	0	1	0	0	0	14769	1261	44	4	3599	4	SMARCA2	9	2115870	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		2115870	139097561	203	26781										
INSL4	3641	broad.mit.edu	37	chr9	5233806	5233806	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccgcaaaaagagaagtggaCgtcacagatttgatccattc	9	10	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:5233806C>A	uc003ziy.2	+	2	454	c.349C>A	c.(349-351)CGT>AGT	p.R117S		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	117					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GAGAAGTGGACGTCACAGATT	0.383													1	0	5.60225e-13	0.009535	6.31961e-13	29	5										A	5233806	C	A	5233806	3	1	89	1	0	0	0	0	1	0	0	0	7768	536	19	4	355	4	INSL4	9	5233806	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3117936	5233806	135979625	204	26782										
IFNA4	3441	broad.mit.edu	37	chr9	21187497	21187497	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggatttgtagctgagcaccaGcacggccatcagtaaagaaa	11	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:21187497G>A	uc003zon.2	-	1	102	c.34C>T	c.(34-36)CTG>TTG	p.L12L		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	12					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTGAGCACCAGCACGGCCATC	0.502													0	0	0	0.01441	0	36	9										A	21187497	G	A	21187497	2	1	89	1	0	0	0	0	0	0	0	1	7539	962	34	2		2	IFNA4	9	21187497	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	15953691	21187497	120025934	205	26783										
B4GALT1	2683	broad.mit.edu	37	chr9	33166812	33166812	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acagtgcggtggtgtggggcActgggaccgaggtcaagttg	19	7	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:33166812A>T	uc003zsg.2	-	1	545	c.356T>A	c.(355-357)GTG>GAG	p.V119E		NM_001497	NP_001488	P15291	B4GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	119	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	basolateral plasma membrane|brush border membrane|desmosome|external side of plasma membrane|extracellular region|glycocalyx|Golgi cisterna membrane|Golgi trans cisterna|integral to membrane	alpha-tubulin binding|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-tubulin binding|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity|protein binding|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(29;0.0084)	GBM - Glioblastoma multiforme(74;0.121)	N-Acetyl-D-glucosamine(DB00141)	GGTGTGGGGCACTGGGACCGA	0.711													0	0	0	0.014323	0	21	33										T	33166812	A	T	33166812	3	4	89	1	0	0	0	0	1	0	0	0	1270	159	6	5	864	5	B4GALT1	9	33166812	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	11979315	33166812	108046619	206	26784										
NOL6	65083	broad.mit.edu	37	chr9	33468850	33468850	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	accagcatggagacaaggaaCccagtaaacccaccctggcc	9	15	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:33468850C>A	uc003zsz.2	-	8	1148	c.1047G>T	c.(1045-1047)GGG>GGT	p.G349G	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zta.2_Silent_p.G349G|NOL6_uc010mjv.2_Silent_p.G349G|NOL6_uc011lob.1_Silent_p.G289G|NOL6_uc003ztb.1_Silent_p.G349G	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	349					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGACAAGGAACCCAGTAAACC	0.572													1	0	1.1777e-47	0.01441	1.64227e-47	95	138										A	33468850	C	A	33468850	2	1	89	1	0	0	0	0	0	0	0	1	10525	494	18	4		4	NOL6	9	33468850	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	302038	33468850	107744581	207	26785										
FLJ46321	389763	broad.mit.edu	37	chr9	84607839	84607839	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgtcagggaatgactcaggGgtgagactaggtcagaaaca	14	7	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:84607839G>T	uc004amn.2	+	4	2501	c.2454G>T	c.(2452-2454)GGG>GGT	p.G818G		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	818						integral to membrane					0						ATGACTCAGGGGTGAGACTAG	0.458													1	0	1.47244e-24	0.00623	1.85729e-24	37	60										T	84607839	G	T	84607839	2	4	89	1	0	0	0	0	0	0	0	1	5932	1219	43	4		4	FLJ46321	9	84607839	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	51138989	84607839	56605592	208	26786										
ZCCHC6	79670	broad.mit.edu	37	chr9	88961372	88961372	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agtcttccgtggcttcctagGtctggacctctgcttcttgt	10	12	4	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:88961372G>T	uc004aoq.2	-	3	759	c.544C>A	c.(544-546)CCT>ACT	p.P182T	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.P182T|ZCCHC6_uc004aou.2_Missense_Mutation_p.P182T|ZCCHC6_uc004aov.2_Missense_Mutation_p.P182T|ZCCHC6_uc004aow.2_Missense_Mutation_p.P182T	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	182					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						GGCTTCCTAGGTCTGGACCTC	0.428													1	0	7.50695e-29	0.01441	9.84955e-29	55	85										T	88961372	G	T	88961372	3	4	89	1	0	0	0	0	1	0	0	0	17589	1261	44	4	4043	4	ZCCHC6	9	88961372	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4353533	88961372	52252059	209	26787										
KIAA1529	57653	broad.mit.edu	37	chr9	100124558	100124558	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggcgcatgggcctgtgggtCtcggggcagcagtgaggcag	20	9	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:100124558C>A	uc011lut.1	+	40	5059	c.4286C>A	c.(4285-4287)TCT>TAT	p.S1429Y	KIAA1529_uc004axe.1_Intron|KIAA1529_uc004axg.1_Missense_Mutation_p.S1290Y|KIAA1529_uc004axh.1_Intron|KIAA1529_uc011luw.1_Intron	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GCCTGTGGGTCTCGGGGCAGC	0.587													1	0	2.33925e-33	0.01441	3.12839e-33	91	100										A	100124558	C	A	100124558	3	1	89	1	0	0	0	0	1	0	0	0	8240	928	32	3		3	KIAA1529	9	100124558	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	11163186	100124558	41088873	210	26788										
GABBR2	9568	broad.mit.edu	37	chr9	101148053	101148053	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggactcgacatctttatgaGcctgacaagagaaagagaca	10	8	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:101148053G>A	uc004ays.2	-	11	1687	c.1531C>T	c.(1531-1533)CTC>TTC	p.L511F		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	511	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	ATCTTTATGAGCCTGACAAGA	0.378													0	0	0	0.010818	0	29	45										A	101148053	G	A	101148053	3	1	89	1	0	0	0	0	1	0	0	0	6156	985	34	2	1330	2	GABBR2	9	101148053	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1023495	101148053	40065378	211	26789										
ACTL7B	10880	broad.mit.edu	37	chr9	111618174	111618174	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctctccagggtcaccctgagCcgtgcccaggggcatggggc	15	15	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:111618174C>A	uc004bdi.2	-	1	102	c.37G>T	c.(37-39)GCT>TCT	p.A13S		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	13						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TCACCCTGAGCCGTGCCCAGG	0.652													1	0	3.09899e-07	0.004482	3.24516e-07	7	94										A	111618174	C	A	111618174	3	1	89	1	0	0	0	0	1	0	0	0	201	739	26	4	1214	4	ACTL7B	9	111618174	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	10470121	111618174	29595257	212	26790										
ACTL7A	10881	broad.mit.edu	37	chr9	111624682	111624682	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggcccccctgcagacacaggCcctccagactgcctctttaa	8	18	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:111624682C>T	uc004bdj.1	+	1	80	c.80C>T	c.(79-81)GCC>GTC	p.A27V		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	27						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0						CAGACACAGGCCCTCCAGACT	0.617													0	0	0	0.01441	0	50	63										T	111624682	C	T	111624682	3	4	89	1	0	0	0	0	1	0	0	0	200	739	26	2	82	2	ACTL7A	9	111624682	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6508	111624682	29588749	213	26791										
KIAA0368	23392	broad.mit.edu	37	chr9	114204677	114204677	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cactggtaggcgaggatagcCcattttaacataaattatag	9	7	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:114204677C>A	uc004bfe.1	-	6	832	c.832G>T	c.(832-834)GGC>TGC	p.G278C	KIAA0368_uc010muc.1_Missense_Mutation_p.G100C	NM_001080398	NP_001073867			KIAA0368 protein												0						CGAGGATAGCCCATTTTAACA	0.378													1	0	0.00198382	0.001984	0.00200185	7	14										A	114204677	C	A	114204677	3	1	89	1	0	0	0	0	1	0	0	0	8171	623	22	4	5405	4	KIAA0368	9	114204677	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2579995	114204677	27008754	214	26792										
RNF183	138065	broad.mit.edu	37	chr9	116060181	116060181	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccttgaggcacagctgatggCcttccaggatgacatggtgg	14	10	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:116060181C>A	uc004bgz.2	-	2	402	c.284G>T	c.(283-285)GGC>GTC	p.G95V	RNF183_uc004bha.2_Missense_Mutation_p.G95V	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	95						integral to membrane	zinc ion binding				0						CAGCTGATGGCCTTCCAGGAT	0.657													1	0	3.19069e-20	0.01441	3.8749e-20	52	40										A	116060181	C	A	116060181	3	1	89	1	0	0	0	0	1	0	0	0	13467	739	26	4	298	4	RNF183	9	116060181	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1855504	116060181	25153250	215	26793										
PTGES2	80142	broad.mit.edu	37	chr9	130886051	130886051	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catgagccagtacttattgcCgaactcggtcacctccttgc	8	14	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:130886051C>T	uc004bti.2	-	4	1094	c.616G>A	c.(616-618)GGC>AGC	p.G206S	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.G15S|PTGES2_uc004btl.2_Missense_Mutation_p.G15S|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	206	Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						TACTTATTGCCGAACTCGGTC	0.592													0	0	0	0.01441	0	45	50										T	130886051	C	T	130886051	3	4	89	1	0	0	0	0	1	0	0	0	12747	652	23	2	533	2	PTGES2	9	130886051	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	14825870	130886051	10327380	216	26794										
ZER1	10444	broad.mit.edu	37	chr9	131516169	131516169	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtgaggcgggtgctgcggggGtccgaaaagaggctgaagaa	20	6	0	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:131516169G>C	uc004bwa.1	-	3	661	c.228C>G	c.(226-228)GAC>GAG	p.D76E		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	76					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TGCTGCGGGGGTCCGAAAAGA	0.627													0	0	0	0.014758	0	5	10										C	131516169	G	C	131516169	3	2	89	1	0	0	0	0	1	0	0	0	17622	1252	44	4	2128	4	ZER1	9	131516169	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	630118	131516169	9697262	217	26795										
GTF3C4	9329	broad.mit.edu	37	chr9	135553561	135553561	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggtgcctcttggcagcactGaccatggacaatcgcctgac	11	13	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:135553561G>C	uc010mzv.2	+	2	813	c.555G>C	c.(553-555)CTG>CTC	p.L185L	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	185					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TGGCAGCACTGACCATGGACA	0.527													0	0	0	0.01441	0	56	51										C	135553561	G	C	135553561	2	2	89	1	0	0	0	0	0	0	0	1	6875	1277	45	1		1	GTF3C4	9	135553561	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4037392	135553561	5659870	218	26796										
ADAMTS13	11093	broad.mit.edu	37	chr9	136323081	136323081	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggtgaaatcgtgagcccctcGctgagtccagccacgagtaa	12	12	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:136323081G>A	uc004cdv.3	+	28	4386	c.3942G>A	c.(3940-3942)TCG>TCA	p.S1314S	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Silent_p.S1258S|ADAMTS13_uc004cdu.1_Silent_p.S1227S|ADAMTS13_uc004cdw.3_Silent_p.S1258S|ADAMTS13_uc004cdx.3_Silent_p.S1227S|ADAMTS13_uc004cdz.3_Silent_p.S984S|ADAMTS13_uc004cea.1_3'UTR|ADAMTS13_uc004ceb.3_Silent_p.S110S|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1314	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TGAGCCCCTCGCTGAGTCCAG	0.607													0	0	0	0.01441	0	61	54										A	136323081	G	A	136323081	2	1	89	1	0	0	0	0	0	0	0	1	258	1074	38	2		2	ADAMTS13	9	136323081	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	769520	136323081	4890350	219	26797										
COL5A1	1289	broad.mit.edu	37	chr9	137701072	137701072	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agctggccgagacggtctccAggggcctgtggggctcccgg	18	13	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:137701072A>T	uc004cfe.2	+	43	3792	c.3410A>T	c.(3409-3411)CAG>CTG	p.Q1137L		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1137	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GACGGTCTCCAGGGGCCTGTG	0.627													0	0	0	0.016723	0	14	11										T	137701072	A	T	137701072	3	4	89	1	0	0	0	0	1	0	0	0	3696	188	7	5	3580	5	COL5A1	9	137701072	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1377991	137701072	3512359	220	26798										
CAMSAP1	157922	broad.mit.edu	37	chr9	138719397	138719397	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgttggagatcggtacaggaGgccggctgctcttctggtgt	16	9	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:138719397G>C	uc004cgr.3	-	8	1079	c.1079C>G	c.(1078-1080)CCT>CGT	p.P360R	CAMSAP1_uc004cgq.3_Missense_Mutation_p.P250R|CAMSAP1_uc010nbg.2_Missense_Mutation_p.P82R	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	360						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CGGTACAGGAGGCCGGCTGCT	0.562													0	0	0	0.008871	0	19	32										C	138719397	G	C	138719397	3	2	89	1	0	0	0	0	1	0	0	0	2611	1000	35	4	3769	4	CAMSAP1	9	138719397	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1018325	138719397	2494034	221	26799										
NOTCH1	4851	broad.mit.edu	37	chr9	139418227	139418227	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcgtgagcaggtcgcaggtGcccccgttgcggcaggggtt	18	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:139418227G>A	uc004chz.2	-	3	345	c.345C>T	c.(343-345)GGC>GGT	p.G115G		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	115	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCGCAGGTGCCCCCGTTGC	0.687			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.014323	0	19	15										A	139418227	G	A	139418227	2	1	89	1	0	0	0	0	0	0	0	1	10547	1306	46	2		2	NOTCH1	9	139418227	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	698830	139418227	1795204	222	26800										
MAMDC4	158056	broad.mit.edu	37	chr9	139751262	139751262	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agccgcggccctgaccacgaCcacaccacaggccaaggtag	11	17	0	1	rs142680518		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:139751262C>A	uc004cjs.2	+	15	1871	c.1821C>A	c.(1819-1821)GAC>GAA	p.D607E	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	686	MAM 4.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTGACCACGACCACACCACAG	0.647													1	0	4.36969e-10	0.016723	4.74595e-10	12	16										A	139751262	C	A	139751262	3	1	89	1	0	0	0	0	1	0	0	0	9204	506	18	4	1879	4	MAMDC4	9	139751262	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	333035	139751262	1462169	223	26801										
ENTPD8	377841	broad.mit.edu	37	chr9	140330634	140330634	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggctcagcgggggcgtggcgTggacacagggtgactcatac	18	10	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:140330634T>G	uc004cmw.2	-	7	1065	c.881A>C	c.(880-882)CAC>CCC	p.H294P	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.H294P	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	294	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGGCGTGGCGTGGACACAGGG	0.657													0	0	0	0.015359	0	35	49										G	140330634	T	G	140330634	3	3	89	1	0	0	0	0	1	0	0	0	5145	1696	59	5	622	5	ENTPD8	9	140330634	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	579372	140330634	882797	224	26802										
ACBD7	414149	broad.mit.edu	37	chr10	15120593	15120593	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggcactcgtcgcatcttccGtcgacaaccctagaaagata	8	13	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:15120593G>A	uc001inv.2	-	4	251	c.203C>T	c.(202-204)ACG>ATG	p.T68M	ACBD7_uc010qby.1_Intron	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	68	ACB.						fatty-acyl-CoA binding				0						CGCATCTTCCGTCGACAACCC	0.363													0	0	0	0.004007	0	14	48										A	15120593	G	A	15120593	3	1	89	1	0	0	0	0	1	0	0	0	127	1145	40	2	67	2	ACBD7	10	15120593	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		15120593	120414154	225	26803										
CUBN	8029	broad.mit.edu	37	chr10	16883004	16883004	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggtactgtggaaccacaaaAcgttccagccaagttcgcat	9	11	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:16883004A>G	uc001ioo.2	-	61	9758	c.9706T>C	c.(9706-9708)TTT>CTT	p.F3236L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3236	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAACCACAAAACGTTCCAGCC	0.368													0	0	0	0.007413	0	20	21										G	16883004	A	G	16883004	3	3	89	1	0	0	0	0	1	0	0	0	4051	43	2	5	1193	5	CUBN	10	16883004	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1762411	16883004	118651743	226	26804										
VIM	7431	broad.mit.edu	37	chr10	17277194	17277194	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccctggaacgccagatgcgTgaaatggaagagaactttgc	12	9	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:17277194T>C	uc001iou.2	+	7	1448	c.1035T>C	c.(1033-1035)CGT>CGC	p.R345R	VIM_uc001iov.1_Silent_p.R345R|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.R345R|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.R303R|VIM_uc001ipc.1_Silent_p.R345R	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	345	Rod.|Coil 2.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GCCAGATGCGTGAAATGGAAG	0.483													0	0	0	0.006122	0	17	43										C	17277194	T	C	17277194	2	2	89	1	0	0	0	0	0	0	0	1	17163	1683	59	5		5	VIM	10	17277194	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	394190	17277194	118257553	227	26805										
KIAA1217	56243	broad.mit.edu	37	chr10	24669846	24669846	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcaaccacccagtctgggtGacccggtcgagcatttatca	9	14	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:24669846G>C	uc001iru.3	+	3	806	c.403G>C	c.(403-405)GAC>CAC	p.D135H	KIAA1217_uc001irs.2_Missense_Mutation_p.D55H|KIAA1217_uc001irt.3_Missense_Mutation_p.D135H|KIAA1217_uc010qcy.1_Missense_Mutation_p.D135H|KIAA1217_uc010qcz.1_Missense_Mutation_p.D135H|KIAA1217_uc001irv.1_5'UTR|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	135					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CAGTCTGGGTGACCCGGTCGA	0.502													0	0	0	0.016723	0	13	46										C	24669846	G	C	24669846	3	2	89	1	0	0	0	0	1	0	0	0	8216	1290	45	1	413	1	KIAA1217	10	24669846	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7392652	24669846	110864901	228	26806										
ARHGAP21	57584	broad.mit.edu	37	chr10	24910248	24910248	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggttcaggtatattgcgggcAttgccgctataagcttcgtt	12	8	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:24910248A>C	uc001isb.2	-	9	1063	c.576T>G	c.(574-576)AAT>AAG	p.N192K	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.N192K|ARHGAP21_uc010qdc.1_Missense_Mutation_p.N27K|ARHGAP21_uc001isc.1_Missense_Mutation_p.N182K	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	191					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TATTGCGGGCATTGCCGCTAT	0.463													0	0	0	0.001168	0	6	7										C	24910248	A	C	24910248	3	2	89	1	0	0	0	0	1	0	0	0	871	214	8	5	5372	5	ARHGAP21	10	24910248	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	240402	24910248	110624499	229	26807										
SVIL	6840	broad.mit.edu	37	chr10	29760165	29760165	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggggctcctttccctggagaAcctggaccttccgatttaaa	10	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:29760165A>T	uc001iut.1	-	31	6290	c.5537T>A	c.(5536-5538)GTT>GAT	p.V1846D	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.V760D|SVIL_uc001iuu.1_Missense_Mutation_p.V1420D	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1846	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TCCCTGGAGAACCTGGACCTT	0.498													0	0	0	0.013537	0	12	10										T	29760165	A	T	29760165	3	4	89	1	0	0	0	0	1	0	0	0	15418	43	2	5	1139	5	SVIL	10	29760165	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	4849917	29760165	105774582	230	26808										
ZNF485	220992	broad.mit.edu	37	chr10	44111919	44111919	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaaagtcttcaaatacaattCgtcctttattagccaccaga	5	10	2	1	rs138982373		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:44111919C>T	uc010qfc.1	+	5	622	c.428C>T	c.(427-429)TCG>TTG	p.S143L	ZNF485_uc010qfd.1_Missense_Mutation_p.S52L	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	143	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAATACAATTCGTCCTTTATT	0.413													0	0	0	0.00499	0	15	53										T	44111919	C	T	44111919	3	4	89	1	0	0	0	0	1	0	0	0	17935	893	31	1	442	1	ZNF485	10	44111919	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	14351754	44111919	91422828	231	26809										
NRBF2	29982	broad.mit.edu	37	chr10	64913495	64913495	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccttccacagagaaatgcctGcctgagattcaggggatctt	10	11	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:64913495G>T	uc001jmj.3	+	4	605	c.381G>T	c.(379-381)CTG>CTT	p.L127L	NRBF2_uc010qip.1_Silent_p.L117L	NM_030759	NP_110386	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	127					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding				0	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGAAATGCCTGCCTGAGATTC	0.507													1	0	1.61879e-10	0.013537	1.76509e-10	12	25										T	64913495	G	T	64913495	2	4	89	1	0	0	0	0	0	0	0	1	10641	1306	46	4		4	NRBF2	10	64913495	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	20801576	64913495	70621252	232	26810										
NODAL	4838	broad.mit.edu	37	chr10	72195635	72195635	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcagtggggaggtccacagGgctggacagctgcagccgga	17	11	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:72195635G>C	uc001jrc.2	-	2	340	c.298C>G	c.(298-300)CCT>GCT	p.P100A		NM_018055	NP_060525	Q96S42	NODAL_HUMAN	nodal precursor	100					growth	extracellular space	cytokine activity|growth factor activity			large_intestine(1)|kidney(1)	2						AGGTCCACAGGGCTGGACAGC	0.572													0	0	0	0.010504	0	19	52										C	72195635	G	C	72195635	3	2	89	1	0	0	0	0	1	0	0	0	10518	1232	43	4	753	4	NODAL	10	72195635	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7282140	72195635	63339112	233	26811										
KIAA1274	27143	broad.mit.edu	37	chr10	72293777	72293777	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcaggaccaacctgggcatgGtcctgggcaccctcatcctg	12	15	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:72293777G>T	uc001jrd.3	+	8	1251	c.970G>T	c.(970-972)GTC>TTC	p.V324F		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	324										ovary(2)|central_nervous_system(1)	3						CCTGGGCATGGTCCTGGGCAC	0.701													1	0	6.72482e-11	0.003163	7.37604e-11	15	12										T	72293777	G	T	72293777	3	4	89	1	0	0	0	0	1	0	0	0	8220	1261	44	4	996	4	KIAA1274	10	72293777	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	98142	72293777	63240970	234	26812										
SEC24C	9632	broad.mit.edu	37	chr10	75523669	75523669	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tataatatcccttgcacatcTgacatggctaagcaggctca	7	11	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:75523669T>A	uc001juw.2	+	9	1334	c.1155T>A	c.(1153-1155)TCT>TCA	p.S385S	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Silent_p.S243S|SEC24C_uc001jux.2_Silent_p.S385S|SEC24C_uc010qko.1_Silent_p.S266S|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	385					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					CTTGCACATCTGACATGGCTA	0.542													0	0	0	0.00499	0	17	9										A	75523669	T	A	75523669	2	1	89	1	0	0	0	0	0	0	0	1	13996	1567	55	5		5	SEC24C	10	75523669	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	3229892	75523669	60011078	235	26813										
DUSP13	51207	broad.mit.edu	37	chr10	76867962	76867962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctcaaagcggttgtttgccGtggccctggggagggcagga	18	9	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:76867962G>A	uc001jws.2	-	2	210	c.155C>T	c.(154-156)ACG>ATG	p.T52M	DUSP13_uc001jwu.2_Intron|DUSP13_uc001jww.2_Intron|DUSP13_uc009xrs.2_Translation_Start_Site|DUSP13_uc001jwt.2_Translation_Start_Site|DUSP13_uc001jwv.2_Intron	NM_001007271	NP_001007272	Q6B8I1	MDSP_HUMAN	muscle-restricted dual specificity phosphatase	52	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GTTGTTTGCCGTGGCCCTGGG	0.662													0	0	0	0.021523	0	21	39										A	76867962	G	A	76867962	3	1	89	1	0	0	0	0	1	0	0	0	4813	1145	40	2	1315	2	DUSP13	10	76867962	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1344293	76867962	58666785	236	26814										
DLG5	9231	broad.mit.edu	37	chr10	79571722	79571722	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gagctggtgcacgtgggggtTgtactgggccaggatggtga	20	6	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:79571722T>A	uc001jzk.2	-	22	4352	c.4282A>T	c.(4282-4284)AAC>TAC	p.N1428Y	DLG5_uc001jzi.2_Missense_Mutation_p.N183Y|DLG5_uc001jzj.2_Missense_Mutation_p.N843Y|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1428	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACGTGGGGGTTGTACTGGGCC	0.667													0	0	0	0.013726	0	31	19										A	79571722	T	A	79571722	3	1	89	1	0	0	0	0	1	0	0	0	4558	1812	63	5	1521	5	DLG5	10	79571722	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	2703760	79571722	55963025	237	26815										
PAPSS2	9060	broad.mit.edu	37	chr10	89472929	89472929	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccctggatggggacaatgtCcgtcatggccttaacagaaa	11	10	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:89472929C>G	uc001kex.2	+	3	506	c.243C>G	c.(241-243)GTC>GTG	p.V81V	PAPSS2_uc001kew.2_Silent_p.V81V|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	81	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		GGGACAATGTCCGTCATGGCC	0.517													0	0	0	0.01441	0	77	51										G	89472929	C	G	89472929	2	3	89	1	0	0	0	0	0	0	0	1	11435	842	30	1		1	PAPSS2	10	89472929	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	9901207	89472929	46061818	238	26816										
SORBS1	10580	broad.mit.edu	37	chr10	97096652	97096652	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagctgcaagaagctatcttGgtggatgcctgaagatggcg	14	8	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:97096652G>T	uc001kkp.2	-	28	3310	c.3265C>A	c.(3265-3267)CAA>AAA	p.Q1089K	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.Q1043K|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1089					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AAGCTATCTTGGTGGATGCCT	0.562													1	0	2.00842e-17	0.010771	2.392e-17	39	19										T	97096652	G	T	97096652	3	4	89	1	0	0	0	0	1	0	0	0	14927	1357	47	4	693	4	SORBS1	10	97096652	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7623723	97096652	38438095	239	26817										
SLIT1	6585	broad.mit.edu	37	chr10	98807755	98807755	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgaagtactgctctttggcTgggaagagaagcagaaatac	12	6	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:98807755T>C	uc001kmw.2	-	15	1718	c.1466_splice	c.e15-1	p.A489_splice	SLIT1_uc009xvh.1_Splice_Site_p.A499_splice	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor						axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCTCTTTGGCTGGGAAGAGAA	0.597													0	0	0	0.010771	0	42	119										C	98807755	T	C	98807755	5	2	89	1	0	0	0	0	0	0	1	0	14739	1594	55	5	3232	5	SLIT1	10	98807755	Splice_Site	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1711103	98807755	36726992	240	26818										
HPS1	3257	broad.mit.edu	37	chr10	100185614	100185614	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgatgccctgccacaggggCaggcagtacatggtgtgggg	17	9	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:100185614C>T	uc010qpf.1	-	12	1362	c.1116G>A	c.(1114-1116)CTG>CTA	p.L372L	HPS1_uc001kpi.1_Silent_p.L372L|HPS1_uc001kpj.1_Silent_p.L279L|HPS1_uc001kpk.1_Intron|HPS1_uc010qpg.1_Silent_p.L4L|HPS1_uc009xwb.2_RNA	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	372					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GCCACAGGGGCAGGCAGTACA	0.627									Hermansky-Pudlak_syndrome		OREG0020430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	22	85										T	100185614	C	T	100185614	2	4	89	1	0	0	0	0	0	0	0	1	7339	697	25	2		2	HPS1	10	100185614	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1377859	100185614	35349133	241	26819										
SH3PXD2A	9644	broad.mit.edu	37	chr10	105495534	105495534	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagtctcttcacagctacgtCccggatgtggcttctgcgga	11	13	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:105495534C>A	uc001kxj.1	-	4	402	c.262G>T	c.(262-264)GAC>TAC	p.D88Y	SH3PXD2A_uc010qqu.1_Missense_Mutation_p.D18Y	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	88	PX.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ACAGCTACGTCCCGGATGTGG	0.572													1	0	4.37601e-64	0.01441	6.2595e-64	107	63										A	105495534	C	A	105495534	3	1	89	1	0	0	0	0	1	0	0	0	14256	855	30	3	3099	3	SH3PXD2A	10	105495534	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5309920	105495534	30039213	242	26820										
DCLRE1A	9937	broad.mit.edu	37	chr10	115596934	115596934	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaatctgattgtatttcccaCcacacttcttcaaatgactc	3	12	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:115596934C>G	uc001law.2	-	8	3767	c.2849G>C	c.(2848-2850)GGT>GCT	p.G950A		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	950					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTATTTCCCACCACACTTCTT	0.373								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.01441	0	43	43										G	115596934	C	G	115596934	3	3	89	1	0	0	0	0	1	0	0	0	4294	507	18	4	281	4	DCLRE1A	10	115596934	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	10101400	115596934	19937813	243	26821										
ATRNL1	26033	broad.mit.edu	37	chr10	116975551	116975551	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgaaataacaaagtccatttAtgttcatggagggtataaag	9	4	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:116975551A>T	uc001lcg.2	+	9	1831	c.1445A>T	c.(1444-1446)TAT>TTT	p.Y482F		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	482	Kelch 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAGTCCATTTATGTTCATGGA	0.363													0	0	0	0.001984	0	7	27										T	116975551	A	T	116975551	3	4	89	1	0	0	0	0	1	0	0	0	1207	449	16	5	1479	5	ATRNL1	10	116975551	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1378617	116975551	18559196	244	26822										
PNLIPRP3	119548	broad.mit.edu	37	chr10	118228771	118228771	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatagatttcacttcaaaaaTatgaagactaatggatcaca	6	6	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:118228771T>C	uc001lcl.3	+	9	1103	c.1002T>C	c.(1000-1002)AAT>AAC	p.N334N		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	334					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		ACTTCAAAAATATGAAGACTA	0.353													0	0	0	0.008361	0	29	16										C	118228771	T	C	118228771	2	2	89	1	0	0	0	0	0	0	0	1	12152	1403	49	5		5	PNLIPRP3	10	118228771	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1253220	118228771	17305976	245	26823										
C10orf84	63877	broad.mit.edu	37	chr10	120095128	120095128	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgtgcttttctgttcagaaTgttttttatgcaattcttga	7	5	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:120095128T>C	uc001ldo.2	-	4	527	c.260A>G	c.(259-261)CAT>CGT	p.H87R	C10orf84_uc010qss.1_Missense_Mutation_p.H87R	NM_022063	NP_071346	Q9H8W3	F204A_HUMAN	hypothetical protein LOC63877	87											0		Colorectal(252;0.101)		all cancers(201;0.0244)		CTGTTCAGAATGTTTTTTATG	0.303													0	0	0	0.001984	0	5	36										C	120095128	T	C	120095128	3	2	89	1	0	0	0	0	1	0	0	0	1621	1464	51	5	465	5	C10orf84	10	120095128	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1866357	120095128	15439619	246	26824										
FAM175B	23172	broad.mit.edu	37	chr10	126519948	126519948	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagatgttgaaaagagtgagCgagttgttgaatcttgtcag	13	4	2	5			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:126519948C>T	uc001lib.3	+	8	739	c.694C>T	c.(694-696)CGA>TGA	p.R232*		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	232	Potential.					BRISC complex	polyubiquitin binding				0						AAAGAGTGAGCGAGTTGTTGA	0.378													0	0	0	0.001168	0	6	44										T	126519948	C	T	126519948	4	4	89	1	0	0	0	0	0	1	0	0	5498	760	27	2	724	2	FAM175B	10	126519948	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6424820	126519948	9014799	247	26825										
CTBP2	1488	broad.mit.edu	37	chr10	126683152	126683152	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agggtgtagaccctctgcacGcccagggaccgctcgatccc	12	16	1	1	rs78653489		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:126683152G>A	uc009yak.2	-	7	953	c.666C>T	c.(664-666)GGC>GGT	p.G222G	CTBP2_uc009yal.2_Silent_p.G222G|CTBP2_uc001lif.3_Silent_p.G222G|CTBP2_uc001lih.3_Silent_p.G222G|CTBP2_uc001lid.3_Silent_p.G290G|CTBP2_uc001lie.3_Silent_p.G762G	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	222					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCCTCTGCACGCCCAGGGACC	0.552													0	0	0	0.020292	0	14	94										A	126683152	G	A	126683152	2	1	89	1	0	0	0	0	0	0	0	1	3998	1074	38	2		2	CTBP2	10	126683152	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	163204	126683152	8851595	248	26826										
MKI67	4288	broad.mit.edu	37	chr10	129906934	129906934	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcttgccatctcctgctggcTctctgtgcgtgtgcgtggtc	12	13	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:129906934T>G	uc001lke.2	-	13	3365	c.3170A>C	c.(3169-3171)GAG>GCG	p.E1057A	MKI67_uc001lkf.2_Missense_Mutation_p.E697A|MKI67_uc009yav.1_Missense_Mutation_p.E632A|MKI67_uc009yaw.1_Missense_Mutation_p.E207A	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1057	16 X 122 AA approximate repeats.|1.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCTGCTGGCTCTCTGTGCGT	0.547													0	0	0	0.01441	0	172	115										G	129906934	T	G	129906934	3	3	89	1	0	0	0	0	1	0	0	0	9598	1551	54	5	6612	5	MKI67	10	129906934	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	3223782	129906934	5627813	249	26827										
VENTX	27287	broad.mit.edu	37	chr10	135053570	135053570	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcttctggccttgccaatggCctgcagctgctgtgcccttg	11	14	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:135053570C>T	uc010quy.1	+	3	548	c.537C>T	c.(535-537)GGC>GGT	p.G179G		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	179					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		TTGCCAATGGCCTGCAGCTGC	0.647													0	0	0	0.01892	0	22	53										T	135053570	C	T	135053570	2	4	89	1	0	0	0	0	0	0	0	1	17150	726	26	2		2	VENTX	10	135053570	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5146636	135053570	481177	250	26828										
EPS8L2	64787	broad.mit.edu	37	chr11	722404	722404	+	Frame_Shift_Del	DEL	G	G	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acctcactgtgccccagatcGtcaacacctgcagtggccca							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:722404delG	uc001lqt.2	+	13	1310	c.1063delG	c.(1063-1065)GTCfs	p.V355fs	EPS8L2_uc001lqu.2_Frame_Shift_Del_p.V355fs|EPS8L2_uc010qwk.1_Frame_Shift_Del_p.V371fs|EPS8L2_uc001lqv.2_Frame_Shift_Del_p.V310fs|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'UTR|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	355						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCCCAGATCGTCAACACCTG	0.657																		47	6	---	---								-	722404	G	-	722404	7	5	89	1	0	1	0	1	0	0	0	0	5196	1145	40	0	1109	0	EPS8L2	11	722404	Frame_Shift_Del	DEL	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		722404	134284112	251	26829										
LRDD	55367	broad.mit.edu	37	chr11	800619	800619	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atctccaccgtgtcagagggCtcggggccccggtaccgctc	13	16	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:800619C>A	uc001lro.1	-	12	2107	c.1965G>T	c.(1963-1965)GAG>GAT	p.E655D	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.E655D|LRDD_uc001lrl.1_Missense_Mutation_p.E498D|LRDD_uc001lrm.1_Missense_Mutation_p.E342D|LRDD_uc001lrn.1_Missense_Mutation_p.E498D|LRDD_uc001lrp.1_Missense_Mutation_p.E317D	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	655					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGTCAGAGGGCTCGGGGCCCC	0.677													1	0	4.75885e-15	0.00499	5.49098e-15	17	1										A	800619	C	A	800619	3	1	89	1	0	0	0	0	1	0	0	0	8936	796	28	4	787	4	LRDD	11	800619	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	78215	800619	134205897	252	26830										
MUC6	4588	broad.mit.edu	37	chr11	1018244	1018244	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgtagcgaggtaggtgttttGtttgtgctgaatgagctgtg	16	3	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:1018244G>C	uc001lsw.2	-	31	4608	c.4557C>G	c.(4555-4557)AAC>AAG	p.N1519K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1519	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TAGGTGTTTTGTTTGTGCTGA	0.547													0	0	0	0.01441	0	121	11										C	1018244	G	C	1018244	3	2	89	1	0	0	0	0	1	0	0	0	9980	1368	48	4	2774	4	MUC6	11	1018244	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	217625	1018244	133988272	253	26831										
OR52N4	390072	broad.mit.edu	37	chr11	5775984	5775984	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acttatcatgctaacactgaAtaaaacagacctaataccag	4	10	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:5775984A>C	uc001mbu.2	+	1	62	c.14A>C	c.(13-15)AAT>ACT	p.N5T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTAACACTGAATAAAACAGAC	0.358													0	0	0	0.00632	0	29	1										C	5775984	A	C	5775984	3	2	89	1	0	0	0	0	1	0	0	0	11129	101	4	5	16	5	OR52N4	11	5775984	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	4757740	5775984	129230532	254	26832										
OR56A1	120796	broad.mit.edu	37	chr11	6048854	6048854	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agccagtgctgccaactctgGaagttggggaagcagatgag	15	8	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:6048854G>T	uc010qzw.1	-	1	81	c.81C>A	c.(79-81)TTC>TTA	p.F27L		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCAACTCTGGAAGTTGGGGA	0.572													1	0	7.75977e-34	0.01441	1.04026e-33	64	5										T	6048854	G	T	6048854	3	4	89	1	0	0	0	0	1	0	0	0	11133	1165	41	3	879	3	OR56A1	11	6048854	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	272870	6048854	128957662	255	26833										
OR10A6	390093	broad.mit.edu	37	chr11	7949365	7949365	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taagcagattcagcagtggtGtcagaagtgagtaagacaat	12	5	2	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:7949365G>T	uc010rbh.1	-	1	845	c.845C>A	c.(844-846)ACA>AAA	p.T282K		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGCAGTGGTGTCAGAAGTGA	0.423													1	0	4.25531e-23	0.01441	5.30719e-23	49	8										T	7949365	G	T	7949365	3	4	89	1	0	0	0	0	1	0	0	0	10894	1377	48	4	102	4	OR10A6	11	7949365	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1900511	7949365	127057151	256	26834										
ZNF143	7702	broad.mit.edu	37	chr11	9522678	9522678	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccttcgaaggctgcggtcgGtcctttacaacatcaaatat	8	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:9522678G>T	uc001mhr.2	+	11	1126	c.1008G>T	c.(1006-1008)CGG>CGT	p.R336R	ZNF143_uc009yfu.2_Silent_p.R335R|ZNF143_uc010rby.1_Silent_p.R305R	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	336	C2H2-type 4.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GCTGCGGTCGGTCCTTTACAA	0.423													1	0	8.27458e-37	0.01441	1.12283e-36	71	10										T	9522678	G	T	9522678	2	4	89	1	0	0	0	0	0	0	0	1	17729	1248	44	4		4	ZNF143	11	9522678	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1573313	9522678	125483838	257	26835										
C11orf58	10944	broad.mit.edu	37	chr11	16776487	16776487	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acgatgatgattcacctgatCctgaaagtccagatgattct	8	9	2	6			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:16776487C>A	uc001mmk.2	+	5	566	c.388C>A	c.(388-390)CCT>ACT	p.P130T	C11orf58_uc010rct.1_Missense_Mutation_p.P86T	NM_014267	NP_055082	O00193	SMAP_HUMAN	small acidic protein isoform a	130	Asp-rich.										0						tTCACCTGATCCTGAAAGTCC	0.393													1	0	1.2476e-16	0.00632	1.4701e-16	29	3										A	16776487	C	A	16776487	3	1	89	1	0	0	0	0	1	0	0	0	1651	855	30	3	406	3	C11orf58	11	16776487	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7253809	16776487	118230029	258	26836										
OR8K5	219453	broad.mit.edu	37	chr11	55927213	55927213	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtatgctcaacaattctattTcctgtgcatttgagcaaagc	7	9	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:55927213T>G	uc010rja.1	-	1	581	c.581A>C	c.(580-582)GAA>GCA	p.E194A		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CAATTCTATTTCCTGTGCATT	0.333													0	0	0	0.001984	0	7	61										G	55927213	T	G	55927213	3	3	89	1	0	0	0	0	1	0	0	0	11245	1783	62	5	345	5	OR8K5	11	55927213	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	39150726	55927213	79079303	259	26837										
OR5T1	390155	broad.mit.edu	37	chr11	56043760	56043760	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttctattcttctactttgtgGgctctattgagatagtcact	7	8	5	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:56043760G>T	uc001nio.1	+	1	646	c.646G>T	c.(646-648)GGC>TGC	p.G216C		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					CTACTTTGTGGGCTCTATTGA	0.408													1	0	1.14856e-27	0.01441	1.48245e-27	76	113										T	56043760	G	T	56043760	3	4	89	1	0	0	0	0	1	0	0	0	11181	1232	43	4	648	4	OR5T1	11	56043760	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	116547	56043760	78962756	260	26838										
FAM111B	374393	broad.mit.edu	37	chr11	58893494	58893494	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acacacacacgcttagttatGatacttgtttctctgatggg	8	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:58893494G>C	uc001nnl.2	+	4	2167	c.1924G>C	c.(1924-1926)GAT>CAT	p.D642H	FAM111B_uc001nnm.2_Missense_Mutation_p.D612H|FAM111B_uc010rko.1_Missense_Mutation_p.D612H	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	642							catalytic activity			ovary(2)	2						GCTTAGTTATGATACTTGTTT	0.413													0	0	0	0.006999	0	35	41										C	58893494	G	C	58893494	3	2	89	1	0	0	0	0	1	0	0	0	5400	1290	45	1	1930	1	FAM111B	11	58893494	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2849734	58893494	76113022	261	26839										
ZP1	22917	broad.mit.edu	37	chr11	60635046	60635046	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggcgtctcatggcaggaggCtcagccacgacctggggtta	15	11	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:60635046C>G	uc001nqd.2	+	1	32	c.12C>G	c.(10-12)GGC>GGG	p.G4G	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	4					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						TGGCAGGAGGCTCAGCCACGA	0.667													0	0	0	0.015359	0	32	31										G	60635046	C	G	60635046	2	3	89	1	0	0	0	0	0	0	0	1	18212	784	28	4		4	ZP1	11	60635046	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1741552	60635046	74371470	262	26840										
MTA2	9219	broad.mit.edu	37	chr11	62363785	62363785	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gacctgtttcagtttgctgtCtgcttcagcagctttcaacc	8	12	4	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:62363785C>G	uc001ntq.1	-	11	1363	c.982G>C	c.(982-984)GAC>CAC	p.D328H	MTA2_uc010rlx.1_Missense_Mutation_p.D155H	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	328					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGTTTGCTGTCTGCTTCAGCA	0.468													0	0	0	0.01892	0	21	23										G	62363785	C	G	62363785	3	3	89	1	0	0	0	0	1	0	0	0	9909	913	32	1	1056	1	MTA2	11	62363785	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1728739	62363785	72642731	263	26841										
SIPA1	6494	broad.mit.edu	37	chr11	65417137	65417137	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctgacagtgagacacccctGacccaggtgagcagaaacca	11	13	0	5			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:65417137G>C	uc001ofb.2	+	11	2798	c.2631G>C	c.(2629-2631)CTG>CTC	p.L877L	SIPA1_uc010rom.1_Silent_p.L775L|SIPA1_uc001ofd.2_Silent_p.L877L	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	877					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						AGACACCCCTGACCCAGGTGA	0.607													0	0	0	0.01441	0	68	65										C	65417137	G	C	65417137	2	2	89	1	0	0	0	0	0	0	0	1	14328	1277	45	1		1	SIPA1	11	65417137	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3053352	65417137	69589379	264	26842										
PAAF1	80227	broad.mit.edu	37	chr11	73625498	73625498	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaggccaaaatgctgctcttGgcccgggaagataagaaact	12	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:73625498G>C	uc001ouk.1	+	8	802	c.768G>C	c.(766-768)TTG>TTC	p.L256F	PAAF1_uc001oul.1_Missense_Mutation_p.L239F|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.L239F	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	256					interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					TGCTGCTCTTGGCCCGGGAAG	0.498													0	0	0	0.013726	0	28	46										C	73625498	G	C	73625498	3	2	89	1	0	0	0	0	1	0	0	0	11362	1339	47	4	798	4	PAAF1	11	73625498	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8208361	73625498	61381018	265	26843										
C11orf30	56946	broad.mit.edu	37	chr11	76255837	76255837	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agagccaaatgtcgctcccaGcttcttcagagaaacagacg	9	12	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:76255837G>A	uc001oxl.2	+	19	3387	c.3244G>A	c.(3244-3246)GCT>ACT	p.A1082T	C11orf30_uc001oxm.2_Missense_Mutation_p.A984T|C11orf30_uc010rsb.1_Missense_Mutation_p.A1097T|C11orf30_uc010rsc.1_Missense_Mutation_p.A1083T|C11orf30_uc001oxn.2_Missense_Mutation_p.A1083T|C11orf30_uc010rsd.1_Missense_Mutation_p.A991T|C11orf30_uc001oxo.1_Missense_Mutation_p.A436T|C11orf30_uc010rse.1_Missense_Mutation_p.A329T|C11orf30_uc001oxp.2_Missense_Mutation_p.A182T	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1082	Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GTCGCTCCCAGCTTCTTCAGA	0.478													0	0	0	0.01441	0	49	55										A	76255837	G	A	76255837	3	1	89	1	0	0	0	0	1	0	0	0	1636	971	34	2	3314	2	C11orf30	11	76255837	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2630339	76255837	58750679	266	26844										
MTNR1B	4544	broad.mit.edu	37	chr11	92715238	92715238	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aacccccaagaaatggctccCcagatccctgaggggctatt	9	14	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:92715238C>G	uc001pdk.1	+	2	952	c.849C>G	c.(847-849)CCC>CCG	p.P283P		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	283	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AAATGGCTCCCCAGATCCCTG	0.498													0	0	0	0.01441	0	116	172										G	92715238	C	G	92715238	2	3	89	1	0	0	0	0	0	0	0	1	9952	610	22	4		4	MTNR1B	11	92715238	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	16459401	92715238	42291278	267	26845										
MAML2	84441	broad.mit.edu	37	chr11	95712374	95712374	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgatgcccgtcctcgactgaTtcaaccctgttcctgactga	8	14	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:95712374T>C	uc001pfw.1	-	5	4494	c.3209A>G	c.(3208-3210)AAT>AGT	p.N1070S		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	1070					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCTCGACTGATTCAACCCTGT	0.512			T	MECT1|CRTC3	salivary gland mucoepidermoid								0	0	0	0.007291	0	27	29										C	95712374	T	C	95712374	3	2	89	1	0	0	0	0	1	0	0	0	9206	1493	52	5	265	5	MAML2	11	95712374	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	2997136	95712374	39294142	268	26846										
MMP20	9313	broad.mit.edu	37	chr11	102477386	102477386	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catggggcagagtgggcttcCccaggaatactttccgaggt	14	10	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:102477386C>T	uc001phc.2	-	6	846	c.833G>A	c.(832-834)GGG>GAG	p.G278E		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	278					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AGTGGGCTTCCCCAGGAATAC	0.537													0	0	0	0.012213	0	6	50										T	102477386	C	T	102477386	3	4	89	1	0	0	0	0	1	0	0	0	9659	623	22	2	638	2	MMP20	11	102477386	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6765012	102477386	32529130	269	26847										
MMP10	4319	broad.mit.edu	37	chr11	102647046	102647046	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agatattctcccctcagagtGctgatggcatcgaaggacaa	10	10	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:102647046G>T	uc001phg.1	-	6	919	c.897C>A	c.(895-897)AGC>AGA	p.S299R		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	299	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CCCTCAGAGTGCTGATGGCAT	0.438													1	0	2.47316e-13	0.015359	2.80123e-13	30	51										T	102647046	G	T	102647046	3	4	89	1	0	0	0	0	1	0	0	0	9649	1310	46	4	553	4	MMP10	11	102647046	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	169660	102647046	32359470	270	26848										
KIAA1826	84437	broad.mit.edu	37	chr11	105880543	105880543	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aatctgcagccgctccttctCtagctgaagccgctcatgtt	8	14	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:105880543C>G	uc001piy.2	-	3	930	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	KIAA1826_uc001piz.2_Missense_Mutation_p.E253Q	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	253	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		CGCTCCTTCTCTAGCTGAAGC	0.463													0	0	0	0.01441	0	63	67										G	105880543	C	G	105880543	3	3	89	1	0	0	0	0	1	0	0	0	8260	922	32	1	284	1	KIAA1826	11	105880543	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3233497	105880543	29125973	271	26849										
ATM	472	broad.mit.edu	37	chr11	108206598	108206598	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatgacctgagacaagatgcTgtcatgcaacaggtcttcca	10	10	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:108206598T>A	uc001pkb.1	+	56	8563	c.8178T>A	c.(8176-8178)GCT>GCA	p.A2726A	ATM_uc009yxr.1_Silent_p.A2726A|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.A1378A	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2726	PI3K/PI4K.		A -> V (in AT).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GACAAGATGCTGTCATGCAAC	0.348			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.010504	0	20	21										A	108206598	T	A	108206598	2	1	89	1	0	0	0	0	0	0	0	1	1109	1567	55	5		5	ATM	11	108206598	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	2326055	108206598	26799918	272	26850										
APOA4	337	broad.mit.edu	37	chr11	116692251	116692251	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggcctcagcgaggcctgcaGgctgtcggcgttctcccgca	15	15	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:116692251G>C	uc001pps.1	-	3	627	c.523C>G	c.(523-525)CTG>GTG	p.L175V		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GAGGCCTGCAGGCTGTCGGCG	0.672													0	0	0	0.01441	0	119	122										C	116692251	G	C	116692251	3	2	89	1	0	0	0	0	1	0	0	0	783	991	35	4	671	4	APOA4	11	116692251	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8485653	116692251	18314265	273	26851										
DSCAML1	57453	broad.mit.edu	37	chr11	117301499	117301499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccccggtccgcatcctggggCttgggtggtgaggcggtaaa	17	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:117301499C>A	uc001prh.1	-	32	5807	c.5805G>T	c.(5803-5805)AAG>AAT	p.K1935N		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1875	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CATCCTGGGGCTTGGGTGGTG	0.637													1	0	1.59228e-47	0.01441	2.20929e-47	93	126										A	117301499	C	A	117301499	3	1	89	1	0	0	0	0	1	0	0	0	4769	796	28	4	544	4	DSCAML1	11	117301499	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	609248	117301499	17705017	274	26852										
ROBO3	64221	broad.mit.edu	37	chr11	124738754	124738754	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcgtggagcagccgccagatCtgctggtctcccgaggcgag	15	13	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:124738754C>A	uc001qbc.2	+	2	409	c.217C>A	c.(217-219)CTG>ATG	p.L73M		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	73	Ig-like C2-type 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GCCGCCAGATCTGCTGGTCTC	0.667													1	0	2.17888e-05	0.006214	2.23526e-05	9	19										A	124738754	C	A	124738754	3	1	89	1	0	0	0	0	1	0	0	0	13515	912	32	3	223	3	ROBO3	11	124738754	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7437255	124738754	10267762	275	26853										
PKNOX2	63876	broad.mit.edu	37	chr11	125221258	125221258	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgatggccacgcagaatgtCccgcccccaccctaccagga	9	17	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:125221258C>A	uc001qbu.2	+	4	371	c.57C>A	c.(55-57)GTC>GTA	p.V19V	PKNOX2_uc010saz.1_Intron|PKNOX2_uc010sba.1_Intron|PKNOX2_uc010sbb.1_Missense_Mutation_p.S2Y	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	19						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CGCAGAATGTCCCGCCCCCAC	0.657													1	0	1.08611e-07	0.010729	1.14381e-07	11	14										A	125221258	C	A	125221258	2	1	89	1	0	0	0	0	0	0	0	1	11983	842	30	3		3	PKNOX2	11	125221258	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	482504	125221258	9785258	276	26854										
PUS3	83480	broad.mit.edu	37	chr11	125765537	125765537	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggttctacaggggcccaggCcaatatacggatgtctggag	14	9	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:125765537C>A	uc001qcy.2	-	3	624	c.526G>T	c.(526-528)GCC>TCC	p.A176S	HYLS1_uc009zbv.2_Intron|HYLS1_uc001qcx.3_Intron	NM_031307	NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	176						nucleus	RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		GGGGCCCAGGCCAATATACGG	0.478													1	0	2.26627e-22	0.007835	2.82014e-22	44	37										A	125765537	C	A	125765537	3	1	89	1	0	0	0	0	1	0	0	0	12832	739	26	4	927	4	PUS3	11	125765537	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	544279	125765537	9240979	277	26855										
LRTM2	654429	broad.mit.edu	37	chr12	1940231	1940231	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	accacggtgcccccagacgtGcccgcagccacccgaaccct	9	21	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:1940231G>A	uc001qjt.2	+	4	1004	c.198G>A	c.(196-198)GTG>GTA	p.V66V	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Silent_p.V66V|LRTM2_uc010sdx.1_Silent_p.V66V|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	66	LRRNT.|Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCCCAGACGTGCCCGCAGCCA	0.642													0	0	0	0.01441	0	94	79										A	1940231	G	A	1940231	2	1	89	1	0	0	0	0	0	0	0	1	9045	1306	46	2		2	LRTM2	12	1940231	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		1940231	131911664	278	26856										
TAS2R9	50835	broad.mit.edu	37	chr12	10962143	10962143	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gttcagggttaactgtttgaAagtacctggaattttactca	9	6	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:10962143A>T	uc001qyx.2	-	1	625	c.532T>A	c.(532-534)TTC>ATC	p.F178I	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	178	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						AACTGTTTGAAAGTACCTGGA	0.378													0	0	0	0.00632	0	26	54										T	10962143	A	T	10962143	3	4	89	1	0	0	0	0	1	0	0	0	15585	14	1	5	410	5	TAS2R9	12	10962143	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	9021912	10962143	122889752	279	26857										
SLCO1B3	28234	broad.mit.edu	37	chr12	21007999	21007999	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtcattcagctatattgctaAagcactaggtggaatcatta	8	7	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:21007999A>T	uc001rek.2	+	3	248	c.122A>T	c.(121-123)AAA>ATA	p.K41I	SLCO1B3_uc001rel.2_Missense_Mutation_p.K41I|SLCO1B3_uc010sil.1_Missense_Mutation_p.K41I|LST-3TM12_uc010sim.1_Missense_Mutation_p.K41I	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	41	Helical; Name=1; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TATATTGCTAAAGCACTAGGT	0.318													0	0	0	0.004007	0	15	20										T	21007999	A	T	21007999	3	4	89	1	0	0	0	0	1	0	0	0	14724	14	1	5	128	5	SLCO1B3	12	21007999	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	10045856	21007999	112843896	280	26858										
CAPRIN2	65981	broad.mit.edu	37	chr12	30863342	30863342	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtctccttgtccagagtcacCactgttaaaggtttcgttgt	9	10	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:30863342C>A	uc001rji.1	-	18	3629	c.2878G>T	c.(2878-2880)GGT>TGT	p.G960C	CAPRIN2_uc001rjf.1_3'UTR|CAPRIN2_uc001rjg.1_Missense_Mutation_p.G627C|CAPRIN2_uc001rjh.1_Missense_Mutation_p.G910C|CAPRIN2_uc001rjj.1_Missense_Mutation_p.G626C|CAPRIN2_uc001rjk.3_3'UTR|CAPRIN2_uc001rjl.3_3'UTR	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	960					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CCAGAGTCACCACTGTTAAAG	0.502													1	0	7.93641e-56	0.01441	1.12365e-55	153	149										A	30863342	C	A	30863342	3	1	89	1	0	0	0	0	1	0	0	0	2636	594	21	4	509	4	CAPRIN2	12	30863342	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	9855343	30863342	102988553	281	26859										
CPNE8	144402	broad.mit.edu	37	chr12	39071345	39071345	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actgggagccatcctttacaGaagaagcatatctgaaaggc	10	9	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:39071345G>A	uc001rls.1	-	17	1367	c.1283C>T	c.(1282-1284)TCT>TTT	p.S428F	CPNE8_uc001rlr.1_Missense_Mutation_p.S87F	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	428	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				ATCCTTTACAGAAGAAGCATA	0.363													0	0	0	0.020292	0	15	29										A	39071345	G	A	39071345	3	1	89	1	0	0	0	0	1	0	0	0	3818	942	33	1	427	1	CPNE8	12	39071345	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8208003	39071345	94780550	282	26860										
TMBIM6	7009	broad.mit.edu	37	chr12	50152022	50152022	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttttctaggagttggcctggGccctgccctggagttttgta	13	9	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:50152022G>A	uc001rux.2	+	5	431	c.299G>A	c.(298-300)GGC>GAC	p.G100D	TMBIM6_uc010sml.1_Missense_Mutation_p.G100D|TMBIM6_uc001ruy.2_Missense_Mutation_p.G158D|TMBIM6_uc001ruz.2_Missense_Mutation_p.G100D	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	100	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						GTTGGCCTGGGCCCTGCCCTG	0.408													0	0	0	0.01441	0	66	94										A	50152022	G	A	50152022	3	1	89	1	0	0	0	0	1	0	0	0	15980	1203	42	2	491	2	TMBIM6	12	50152022	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11080677	50152022	83699873	283	26861										
KRT83	3889	broad.mit.edu	37	chr12	52709714	52709714	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagcaggcgcctgtaggtggCgatctcgatatccaggccta	13	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:52709714C>A	uc001saf.2	-	7	1288	c.1225G>T	c.(1225-1227)GCC>TCC	p.A409S		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	409	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CTGTAGGTGGCGATCTCGATA	0.597													1	0	1.98135e-44	0.01441	2.72866e-44	62	68										A	52709714	C	A	52709714	3	1	89	1	0	0	0	0	1	0	0	0	8497	768	27	4	268	4	KRT83	12	52709714	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2557692	52709714	81142181	284	26862										
KRT2	3849	broad.mit.edu	37	chr12	53039197	53039197	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccttggatgccacatttgatGaaatggtgctgcttgtcaca	10	9	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:53039197G>A	uc001sat.2	-	9	1559	c.1526C>T	c.(1525-1527)TCA>TTA	p.S509L		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	509	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		CACATTTGATGAAATGGTGCT	0.537													0	0	0	0.01441	0	68	68										A	53039197	G	A	53039197	3	1	89	1	0	0	0	0	1	0	0	0	8457	1294	45	1	397	1	KRT2	12	53039197	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	329483	53039197	80812698	285	26863										
ITGA5	3678	broad.mit.edu	37	chr12	54799117	54799117	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaggccgcccgtcaggggtcCgatccatgagcaggggtgcc	17	13	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:54799117C>T	uc001sga.2	-	12	1126	c.1058G>A	c.(1057-1059)CGG>CAG	p.R353Q	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	353	Extracellular (Potential).|FG-GAP 5.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						GTCAGGGGTCCGATCCATGAG	0.652													0	0	0	0.00632	0	25	12										T	54799117	C	T	54799117	3	4	89	1	0	0	0	0	1	0	0	0	7879	652	23	2	2167	2	ITGA5	12	54799117	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1759920	54799117	79052778	286	26864										
NCKAP1L	3071	broad.mit.edu	37	chr12	54911366	54911366	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cattcgtgatgaggtcacctGgctggttcgccacacagaga	12	11	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:54911366G>T	uc001sgc.3	+	12	1224	c.1145G>T	c.(1144-1146)TGG>TTG	p.W382L	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.W332L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	382					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GAGGTCACCTGGCTGGTTCGC	0.448													1	0	3.86236e-30	0.01441	5.11602e-30	42	43										T	54911366	G	T	54911366	3	4	89	1	0	0	0	0	1	0	0	0	10222	1357	47	4	1191	4	NCKAP1L	12	54911366	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	112249	54911366	78940529	287	26865										
KIAA0748	9840	broad.mit.edu	37	chr12	55357674	55357674	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgtgatcctcttggccaaaGcccagactgaagaggacatc	10	11	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:55357674G>T	uc001sgn.3	-	8	617	c.507C>A	c.(505-507)GGC>GGA	p.G169G	KIAA0748_uc001sgl.3_Silent_p.G31G|KIAA0748_uc001sgm.3_5'UTR|KIAA0748_uc010spb.1_5'UTR|KIAA0748_uc010spc.1_Silent_p.G31G|KIAA0748_uc010spd.1_Silent_p.G169G|KIAA0748_uc001sgo.3_Intron	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	169										ovary(1)|central_nervous_system(1)	2						CTTGGCCAAAGCCCAGACTGA	0.478													1	0	7.07328e-35	0.01441	9.50526e-35	68	64										T	55357674	G	T	55357674	2	4	89	1	0	0	0	0	0	0	0	1	8190	958	34	4		4	KIAA0748	12	55357674	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	446308	55357674	78494221	288	26866										
SILV	6490	broad.mit.edu	37	chr12	56349451	56349451	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccatgcaggcttccttgggcAgcctggaagaagtgtcagca	13	11	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:56349451A>C	uc001sip.2	-	9	1590	c.1559T>G	c.(1558-1560)CTG>CGG	p.L520R	SILV_uc001siq.2_Missense_Mutation_p.L520R|SILV_uc010spx.1_Missense_Mutation_p.L434R|SILV_uc001sir.2_Missense_Mutation_p.L520R	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	520	Lumenal (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						TTCCTTGGGCAGCCTGGAAGA	0.577													0	0	0	0.012213	0	30	42										C	56349451	A	C	56349451	3	2	89	1	0	0	0	0	1	0	0	0	14322	188	7	5	438	5	SILV	12	56349451	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	991777	56349451	77502444	289	26867										
IL23A	51561	broad.mit.edu	37	chr12	56733306	56733306	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaggactcagggacaacagtCaggtaccactgggatgtggc	14	9	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:56733306C>T	uc001sla.2	+	2	425	c.259C>T	c.(259-261)CAG>TAG	p.Q87*		NM_016584	NP_057668	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19 precursor	87					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity				0						GGACAACAGTCAGGTACCACT	0.493													0	0	0	0.004656	0	25	28										T	56733306	C	T	56733306	4	4	89	1	0	0	0	0	0	1	0	0	7675	827	29	1	265	1	IL23A	12	56733306	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	383855	56733306	77118589	290	26868										
PIP4K2C	79837	broad.mit.edu	37	chr12	57989742	57989742	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttccttatctcctacgatcgGactctggtcatcaaagaagt	7	11	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:57989742G>C	uc001sou.2	+	4	572	c.441G>C	c.(439-441)CGG>CGC	p.R147R	PIP4K2C_uc001sot.2_Silent_p.R147R|PIP4K2C_uc010srs.1_Silent_p.R129R|PIP4K2C_uc010srt.1_Intron	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	147	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					CCTACGATCGGACTCTGGTCA	0.522													0	0	0	0.01441	0	52	85										C	57989742	G	C	57989742	2	2	89	1	0	0	0	0	0	0	0	1	11938	1161	41	1		1	PIP4K2C	12	57989742	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1256436	57989742	75862153	291	26869										
BEST3	144453	broad.mit.edu	37	chr12	70070774	70070774	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccaagtcatgccctgcgtaGcctttggtgggatccaaaaa	10	11	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:70070774G>A	uc001svg.2	-	7	1016	c.789C>T	c.(787-789)GGC>GGT	p.G263G	BEST3_uc001svd.1_Silent_p.G263G|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Intron|BEST3_uc010stm.1_Silent_p.G157G|BEST3_uc001svh.2_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	263	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GCCCTGCGTAGCCTTTGGTGG	0.502													0	0	0	0.01441	0	59	49										A	70070774	G	A	70070774	2	1	89	1	0	0	0	0	0	0	0	1	1406	958	34	2		2	BEST3	12	70070774	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	12081032	70070774	63781121	292	26870										
PPFIA2	8499	broad.mit.edu	37	chr12	81688795	81688795	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggcaggctgccacgtaccacGcaggcattcccaaccaaagc	10	16	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:81688795G>A	uc001szo.1	-	24	2905	c.2744C>T	c.(2743-2745)GCG>GTG	p.A915V	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	841										ovary(3)|lung(2)|pancreas(1)	6						CACGTACCACGCAGGCATTCC	0.348													0	0	0	0.004482	0	8	28										A	81688795	G	A	81688795	3	1	89	1	0	0	0	0	1	0	0	0	12310	1087	38	2	1065	2	PPFIA2	12	81688795	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	11618021	81688795	52163100	293	26871										
CEP290	80184	broad.mit.edu	37	chr12	88530508	88530508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctaattgtttttcaagttggCaaatttcattacgtaaaaac	5	6	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:88530508C>T	uc001tar.2	-	6	697	c.353G>A	c.(352-354)TGC>TAC	p.C118Y	CEP290_uc009zsl.1_RNA	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	118	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TTCAAGTTGGCAAATTTCATT	0.338													0	0	0	0.007413	0	20	38										T	88530508	C	T	88530508	3	4	89	1	0	0	0	0	1	0	0	0	3253	710	25	2	7282	2	CEP290	12	88530508	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6841713	88530508	45321387	294	26872										
FGD6	55785	broad.mit.edu	37	chr12	95485582	95485582	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agacgaacaagcttggcataCaatctgaaaacacattggaa	8	8	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:95485582C>T	uc001tdp.3	-	17	3975	c.3751G>A	c.(3751-3753)GTA>ATA	p.V1251I	FGD6_uc009zsx.2_Missense_Mutation_p.V384I|FGD6_uc001tdq.1_Missense_Mutation_p.V287I	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1251	FYVE-type.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						GCTTGGCATACAATCTGAAAA	0.328													0	0	0	0.004482	0	9	25										T	95485582	C	T	95485582	3	4	89	1	0	0	0	0	1	0	0	0	5837	478	17	2	561	2	FGD6	12	95485582	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6955074	95485582	38366313	295	26873										
PAH	5053	broad.mit.edu	37	chr12	103288653	103288653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catactcatctttctttaaaCgagaaggtctagattcaatg	6	8	5	2	rs62508695		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:103288653C>T	uc001tjq.1	-	4	684	c.212G>A	c.(211-213)CGT>CAT	p.R71H	PAH_uc010swc.1_Missense_Mutation_p.R71H	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	71	ACT.				catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TTTCTTTAAACGAGAAGGTCT	0.443													0	0	0	0.016522	0	23	89										T	103288653	C	T	103288653	3	4	89	1	0	0	0	0	1	0	0	0	11394	536	19	2	1190	2	PAH	12	103288653	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7803071	103288653	30563242	296	26874										
HSP90B1	7184	broad.mit.edu	37	chr12	104327817	104327817	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttggttaaaaaccttggtacCatagccaaatctgggacaag	9	8	1	0	rs144387251	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:104327817C>T	uc001tkb.1	+	5	600	c.495C>T	c.(493-495)ACC>ACT	p.T165T	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Silent_p.T165T	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	165					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	ACCTTGGTACCATAGCCAAAT	0.438													0	0	0	0.012213	0	31	50										T	104327817	C	T	104327817	2	4	89	1	0	0	0	0	0	0	0	1	7403	581	21	2		2	HSP90B1	12	104327817	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1039164	104327817	29524078	297	26875										
ALDH1L2	160428	broad.mit.edu	37	chr12	105459055	105459055	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taaaacatacctgtccatttAtctctgtccaagctccaggg	6	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:105459055A>T	uc001tlc.2	-	6	903	c.776T>A	c.(775-777)ATA>AAA	p.I259K	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	259					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						CTGTCCATTTATCTCTGTCCA	0.458													0	0	0	0.012213	0	32	51										T	105459055	A	T	105459055	3	4	89	1	0	0	0	0	1	0	0	0	495	449	16	5	2067	5	ALDH1L2	12	105459055	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	1131238	105459055	28392840	298	26876										
PITPNM2	57605	broad.mit.edu	37	chr12	123481053	123481053	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgctgctctgactctcagaCaccggctggttactgtagca	10	13	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:123481053C>A	uc001uej.1	-	12	1873	c.1734G>T	c.(1732-1734)GTG>GTT	p.V578V	PITPNM2_uc001uek.1_Silent_p.V578V	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	578					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GACTCTCAGACACCGGCTGGT	0.652													1	0	1.1804e-14	0.021523	1.35917e-14	23	48										A	123481053	C	A	123481053	2	1	89	1	0	0	0	0	0	0	0	1	11951	465	17	4		4	PITPNM2	12	123481053	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	18021998	123481053	10370842	299	26877										
XPO4	64328	broad.mit.edu	37	chr13	21374421	21374421	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agccaattatccactgagaaCcctctgtatctgctccgaac	6	14	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:21374421C>T	uc001unq.3	-	15	2057	c.2021G>A	c.(2020-2022)GGT>GAT	p.G674D		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	674					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CCACTGAGAACCCTCTGTATC	0.413													0	0	0	0.010771	0	40	45										T	21374421	C	T	21374421	3	4	89	1	0	0	0	0	1	0	0	0	17443	507	18	2	1470	2	XPO4	13	21374421	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		21374421	93795457	300	26878										
KL	9365	broad.mit.edu	37	chr13	33591101	33591101	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggggctgcgctactaccggCgcctgctggagcggctgcgg	18	13	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:33591101C>G	uc001uus.2	+	1	531	c.523C>G	c.(523-525)CGC>GGC	p.R175G	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	175	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CTACTACCGGCGCCTGCTGGA	0.726													0	0	0	0.013537	0	11	16										G	33591101	C	G	33591101	3	3	89	1	0	0	0	0	1	0	0	0	8331	768	27	4	525	4	KL	13	33591101	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	12216680	33591101	81578777	301	26879										
LRCH1	23143	broad.mit.edu	37	chr13	47243194	47243194	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctgtccgccctgcctgcctGcctgtgtggtctgcctctca	11	17	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:47243194G>C	uc001vbj.2	+	3	718	c.482G>C	c.(481-483)TGC>TCC	p.C161S	LRCH1_uc010acp.2_Missense_Mutation_p.C161S|LRCH1_uc001vbk.2_Missense_Mutation_p.C161S|LRCH1_uc001vbl.3_Missense_Mutation_p.C161S	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	161	LRR 3.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CTGCCTGCCTGCCTGTGTGGT	0.443													0	0	0	0.01441	0	82	107										C	47243194	G	C	47243194	3	2	89	1	0	0	0	0	1	0	0	0	8932	1319	46	4	492	4	LRCH1	13	47243194	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	13652093	47243194	67926684	302	26880										
NEK5	341676	broad.mit.edu	37	chr13	52663442	52663442	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aaattttctctgaaggtactCagcaggccttagaaaataag	8	7	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:52663442C>T	uc001vge.2	-	14	1356	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	406							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGAAGGTACTCAGCAGGCCTT	0.333													0	0	0	0.00308	0	8	14										T	52663442	C	T	52663442	3	4	89	1	0	0	0	0	1	0	0	0	10327	835	29	1	946	1	NEK5	13	52663442	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5420248	52663442	62506436	303	26881										
DIAPH3	81624	broad.mit.edu	37	chr13	60686272	60686272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cttcaggttgggaagtggagGtctctctttcttgctccctg	12	10	4	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:60686272G>A	uc001vht.2	-	3	481	c.262C>T	c.(262-264)CCT>TCT	p.P88S	DIAPH3_uc001vhw.1_Missense_Mutation_p.P77S|DIAPH3_uc010aed.1_Missense_Mutation_p.P77S|DIAPH3_uc010aee.1_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	88					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGAAGTGGAGGTCTCTCTTTC	0.438													0	0	0	0.01441	0	97	129										A	60686272	G	A	60686272	3	1	89	1	0	0	0	0	1	0	0	0	4520	1261	44	2	3443	2	DIAPH3	13	60686272	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	8022830	60686272	54483606	304	26882										
DZIP1	22873	broad.mit.edu	37	chr13	96277135	96277135	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcttcttctttccacctgtCaaataacttcaaaaagtctt	2	11	6	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:96277135C>G	uc001vmk.2	-	8	1711	c.859G>C	c.(859-861)GAC>CAC	p.D287H	DZIP1_uc001vml.2_Missense_Mutation_p.D287H	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	287	Potential.				germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TTCCACCTGTCAAATAACTTC	0.294													0	0	0	0.009096	0	4	15										G	96277135	C	G	96277135	3	3	89	1	0	0	0	0	1	0	0	0	4863	826	29	1	1808	1	DZIP1	13	96277135	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	35590863	96277135	18892743	305	26883										
DOCK9	23348	broad.mit.edu	37	chr13	99532221	99532221	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acatcaaagaaaaaccatgaGtactaaaagaaaaaagaaca	5	6	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:99532221G>T	uc001vnt.2	-	27	2932	c.2877C>A	c.(2875-2877)TAC>TAA	p.Y959*	DOCK9_uc001vnw.2_Nonsense_Mutation_p.Y958*|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Nonsense_Mutation_p.Y959*|DOCK9_uc010tis.1_Nonsense_Mutation_p.Y958*|DOCK9_uc010tit.1_Nonsense_Mutation_p.Y959*|DOCK9_uc010afu.1_Nonsense_Mutation_p.Y805*	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	959					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AAAACCATGAGTACTAAAAGA	0.239													1	0	2.35188e-11	0.006122	2.61582e-11	18	21										T	99532221	G	T	99532221	4	4	89	1	0	0	0	0	0	1	0	0	4694	1024	36	4	3513	4	DOCK9	13	99532221	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3255086	99532221	15637657	306	26884										
NALCN	259232	broad.mit.edu	37	chr13	102029296	102029296	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atttgtaattctggtccttgGcagttcaaatcggaaataaa	8	6	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:102029296G>T	uc001vox.1	-	5	676	c.487C>A	c.(487-489)CCA>ACA	p.P163T	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.P163T|NALCN_uc001vpa.2_Missense_Mutation_p.P163T	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	163	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGGTCCTTGGCAGTTCAAAT	0.378													1	0	2.41591e-17	0.004656	2.87116e-17	27	36										T	102029296	G	T	102029296	3	4	89	1	0	0	0	0	1	0	0	0	10148	1203	42	4	4889	4	NALCN	13	102029296	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2497075	102029296	13140582	307	26885										
ERCC5	2073	broad.mit.edu	37	chr13	103510737	103510737	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatgaaagagttcaccaagcGcagaagaacattatttgaag	9	6	1	5	rs146833751	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:103510737G>A	uc001vpw.2	+	6	1084	c.641G>A	c.(640-642)CGC>CAC	p.R214H	ERCC5_uc001vpu.1_Missense_Mutation_p.R668H|ERCC5_uc010tjb.1_Missense_Mutation_p.R214H|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.R46H	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	214					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTCACCAAGCGCAGAAGAACA	0.383			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.010504	0	20	104										A	103510737	G	A	103510737	3	1	89	1	0	0	0	0	1	0	0	0	5216	1087	38	2	663	2	ERCC5	13	103510737	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1481441	103510737	11659141	308	26886										
F10	2159	broad.mit.edu	37	chr13	113803477	113803477	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggcgcacccacgagaagggCcggcagtccaccaggctcaa	14	15	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:113803477C>A	uc001vsx.2	+	8	1170	c.1113C>A	c.(1111-1113)GGC>GGA	p.G371G	F10_uc001vsy.2_3'UTR|F10_uc001vsz.2_3'UTR	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	371	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACGAGAAGGGCCGGCAGTCCA	0.637													1	0	1.06801e-11	0.009535	1.19505e-11	31	37										A	113803477	C	A	113803477	2	1	89	1	0	0	0	0	0	0	0	1	5336	726	26	4		4	F10	13	113803477	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	10292740	113803477	1366401	309	26887										
OR4K17	390436	broad.mit.edu	37	chr14	20586121	20586121	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catggctcttgggtctccttCactcagggtttcagatacca	9	12	5	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:20586121C>G	uc001vwo.1	+	1	556	c.556C>G	c.(556-558)CAC>GAC	p.H186D		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GGGTCTCCTTCACTCAGGGTT	0.453													0	0	0	0.01441	0	60	94										G	20586121	C	G	20586121	3	3	89	1	0	0	0	0	1	0	0	0	11071	826	29	1	558	1	OR4K17	14	20586121	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		20586121	86763419	310	26888										
TEP1	7011	broad.mit.edu	37	chr14	20876347	20876347	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atggtcttcaggtcagaaagTgtggccaggcactggttctc	13	9	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:20876347T>A	uc001vxe.2	-	2	292	c.252A>T	c.(250-252)ACA>ACT	p.T84T	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.T84T	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	84	TEP1 N-terminal 3.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGTCAGAAAGTGTGGCCAGGC	0.552													0	0	0	0.01441	0	75	69										A	20876347	T	A	20876347	2	1	89	1	0	0	0	0	0	0	0	1	15756	1683	59	5		5	TEP1	14	20876347	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	290226	20876347	86473193	311	26889										
RNASE9	390443	broad.mit.edu	37	chr14	21024720	21024720	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtttttgcatttcattttgcCatgaacaagtgataaggacg	9	6	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:21024720C>T	uc010aho.2	-	4	668	c.509G>A	c.(508-510)TGG>TAG	p.W170*	RNASE9_uc001vxq.3_Nonsense_Mutation_p.W175*|RNASE9_uc010ahp.2_Nonsense_Mutation_p.W175*|RNASE9_uc010ahq.2_Nonsense_Mutation_p.W175*|RNASE9_uc010ahr.2_Nonsense_Mutation_p.W175*|RNASE9_uc010ahs.2_Nonsense_Mutation_p.W170*|RNASE9_uc010aht.2_Nonsense_Mutation_p.W170*|RNASE9_uc010ahu.2_Nonsense_Mutation_p.W170*	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	170						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TTCATTTTGCCATGAACAAGT	0.383													0	0	0	0.003163	0	14	17										T	21024720	C	T	21024720	4	4	89	1	0	0	0	0	0	1	0	0	13410	595	21	2	112	2	RNASE9	14	21024720	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	148373	21024720	86324820	312	26890										
TGM1	7051	broad.mit.edu	37	chr14	24723917	24723917	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acggaaggtgtgctgcttggCcagcacctgcccgctctcct	12	15	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:24723917C>A	uc001wod.2	-	13	2165	c.2041G>T	c.(2041-2043)GCC>TCC	p.A681S	TGM1_uc010tog.1_Missense_Mutation_p.A239S	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	681					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGCTGCTTGGCCAGCACCTGC	0.627													1	0	1.7104e-27	0.01441	2.20248e-27	62	77										A	24723917	C	A	24723917	3	1	89	1	0	0	0	0	1	0	0	0	15826	739	26	4	424	4	TGM1	14	24723917	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3699197	24723917	82625623	313	26891										
SCFD1	23256	broad.mit.edu	37	chr14	31119826	31119826	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgcaagaaacagtctttttaCaggtgatacacttggagctg	10	7	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:31119826C>T	uc001wqm.1	+	9	749	c.725C>T	c.(724-726)ACA>ATA	p.T242I	SCFD1_uc001wqn.1_Missense_Mutation_p.T175I|SCFD1_uc010tpg.1_Missense_Mutation_p.T183I|SCFD1_uc010tph.1_Missense_Mutation_p.T57I|SCFD1_uc010amf.1_Missense_Mutation_p.T57I|SCFD1_uc010tpi.1_Missense_Mutation_p.T150I|SCFD1_uc010amd.1_Missense_Mutation_p.T74I|SCFD1_uc010ame.1_Missense_Mutation_p.T175I	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	242					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AGTCTTTTTACAGGTGATACA	0.289													0	0	0	0.007291	0	23	40										T	31119826	C	T	31119826	3	4	89	1	0	0	0	0	1	0	0	0	13889	478	17	2	759	2	SCFD1	14	31119826	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6395909	31119826	76229714	314	26892										
MIPOL1	145282	broad.mit.edu	37	chr14	37777260	37777260	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttctgtgtcccttttttctaGgctagaaaatattaaccctg	6	9	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:37777260G>C	uc001wuc.2	+	9	1127	c.624_splice	c.e9-1	p.V208_splice	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Splice_Site_p.V177_splice|MIPOL1_uc001wud.2_Splice_Site_p.V208_splice|MIPOL1_uc010ams.2_Splice_Site_p.V208_splice|MIPOL1_uc001wue.2_Splice_Site_p.V177_splice|MIPOL1_uc010amt.2_Splice_Site_p.V27_splice	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		CTTTTTTCTAGGCTAGAAAAT	0.358													0	0	0	0.006999	0	38	56										C	37777260	G	C	37777260	5	2	89	1	0	0	0	0	0	0	1	0	9593	1014	35	4	645	4	MIPOL1	14	37777260	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	6657434	37777260	69572280	315	26893										
CLEC14A	161198	broad.mit.edu	37	chr14	38723983	38723983	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgacaagccccagtactgtCatggtcaagatcaccaacac	7	13	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:38723983C>G	uc001wum.1	-	1	1592	c.1245G>C	c.(1243-1245)ATG>ATC	p.M415I		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	415	Helical; (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCAGTACTGTCATGGTCAAGA	0.557													0	0	0	0.013726	0	33	29										G	38723983	C	G	38723983	3	3	89	1	0	0	0	0	1	0	0	0	3499	826	29	1	231	1	CLEC14A	14	38723983	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	946723	38723983	68625557	316	26894										
EXOC5	10640	broad.mit.edu	37	chr14	57689135	57689135	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aagtcagaaggatcagagagCttaaaaacaaaaatcaaaca	7	6	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:57689135C>A	uc001xct.2	-	13	1548	c.1297_splice	c.e13-1	p.L433_splice	EXOC5_uc001xcs.2_Splice_Site_p.L112_splice|EXOC5_uc010trg.1_Splice_Site_p.L378_splice|EXOC5_uc010trh.1_Splice_Site_p.L368_splice	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein						exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						GATCAGAGAGCTTAAAAACAA	0.308													1	0	1.96895e-08	0.016522	2.08543e-08	22	31										A	57689135	C	A	57689135	5	1	89	1	0	0	0	0	0	0	1	0	5307	811	28	4	854	4	EXOC5	14	57689135	Splice_Site	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	18965152	57689135	49660405	317	26895										
C14orf115	55237	broad.mit.edu	37	chr14	74824202	74824202	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccgccaccagtactttgcccCtgtggtggggctggaagagg	15	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:74824202C>A	uc001xpw.3	+	2	907	c.716C>A	c.(715-717)CCT>CAT	p.P239H		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	239					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		TACTTTGCCCCTGTGGTGGGG	0.687													1	0	3.28156e-27	0.01441	4.20615e-27	46	76										A	74824202	C	A	74824202	3	1	89	1	0	0	0	0	1	0	0	0	1740	681	24	4	718	4	C14orf115	14	74824202	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	17135067	74824202	32525338	318	26896										
FLVCR2	55640	broad.mit.edu	37	chr14	76107313	76107313	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcagcttctttatgactggCtatctcccactgggatttga	8	10	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:76107313C>A	uc001xrs.2	+	7	1627	c.1251C>A	c.(1249-1251)GGC>GGA	p.G417G	FLVCR2_uc010tvd.1_Silent_p.G212G	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	417	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTATGACTGGCTATCTCCCAC	0.532													1	0	1.57351e-24	0.017118	1.98027e-24	35	58										A	76107313	C	A	76107313	2	1	89	1	0	0	0	0	0	0	0	1	5946	784	28	4		4	FLVCR2	14	76107313	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1283111	76107313	31242227	319	26897										
EML5	161436	broad.mit.edu	37	chr14	89148328	89148328	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cttacagtagcacagatgggCagataagggtgtgtagctaa	13	6	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:89148328C>T	uc001xxg.2	-	22	3216	c.3030G>A	c.(3028-3030)CTG>CTA	p.L1010L	EML5_uc001xxh.1_Silent_p.L149L	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1010	WD 16.					cytoplasm|microtubule				ovary(3)	3						CACAGATGGGCAGATAAGGGT	0.408													0	0	0	0.011902	0	44	54										T	89148328	C	T	89148328	2	4	89	1	0	0	0	0	0	0	0	1	5100	697	25	2		2	EML5	14	89148328	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	13041015	89148328	18201212	320	26898										
ATXN3	4287	broad.mit.edu	37	chr14	92555107	92555107	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgagccaagaaaagtgcaaGatatgtatctgatattaatt	8	4	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:92555107G>C	uc001yac.3	-	6	511	c.442C>G	c.(442-444)CTT>GTT	p.L148V	ATXN3_uc010aug.2_Missense_Mutation_p.L133V|ATXN3_uc001yad.3_Missense_Mutation_p.L93V|ATXN3_uc010auh.2_Missense_Mutation_p.L82V|ATXN3_uc001yae.3_Missense_Mutation_p.L50V|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	148	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		AAAAGTGCAAGATATGTATCT	0.323													0	0	0	0.01441	0	127	144										C	92555107	G	C	92555107	3	2	89	1	0	0	0	0	1	0	0	0	1213	942	33	1	667	1	ATXN3	14	92555107	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3406779	92555107	14794433	321	26899										
DYNC1H1	1778	broad.mit.edu	37	chr14	102498707	102498707	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggagtccatctgcctgctgCtgggggaaagcaccacagac	13	12	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:102498707C>A	uc001yks.2	+	52	10146	c.9982C>A	c.(9982-9984)CTG>ATG	p.L3328M		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3328	Stalk (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CTGCCTGCTGCTGGGGGAAAG	0.577													1	0	4.99412e-61	0.01441	7.12528e-61	186	115										A	102498707	C	A	102498707	3	1	89	1	0	0	0	0	1	0	0	0	4841	796	28	4	10188	4	DYNC1H1	14	102498707	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	9943600	102498707	4850833	322	26900										
ZNF839	55778	broad.mit.edu	37	chr14	102792535	102792535	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cacagtcctgcttcctaagtGacttatgccaacctcctgct	6	15	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:102792535G>C	uc001ylo.2	+	2	504	c.154G>C	c.(154-156)GAC>CAC	p.D52H	ZNF839_uc010awk.1_Missense_Mutation_p.D168H|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Missense_Mutation_p.D52H|ZNF839_uc001ylr.2_Missense_Mutation_p.D52H	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	52						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CTTCCTAAGTGACTTATGCCA	0.607													0	0	0	0.006999	0	38	17										C	102792535	G	C	102792535	3	2	89	1	0	0	0	0	1	0	0	0	18185	1290	45	1	508	1	ZNF839	14	102792535	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	293828	102792535	4557005	323	26901										
C14orf73	91828	broad.mit.edu	37	chr14	103566640	103566640	+	Frame_Shift_Del	DEL	C	C	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccacagactccagctcagggCtcccggcgaacaagcagcag							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:103566640delC	uc001ymk.2	+	1	160	c.84delC	c.(82-84)GGCfs	p.G28fs		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	28											0		Melanoma(154;0.155)	Epithelial(46;0.221)			CAGCTCAGGGCTCCCGGCGAA	0.657																		7	15	---	---								-	103566640	C	-	103566640	7	5	89	1	0	1	0	1	0	0	0	0	1779	784	28	0	86	0	C14orf73	14	103566640	Frame_Shift_Del	DEL	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	774105	103566640	3782900	324	26902										
KIF26A	26153	broad.mit.edu	37	chr14	104642734	104642734	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcgcggtgggcatccgcagcCcagaccatccactccagcct	10	18	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:104642734C>G	uc001yos.3	+	12	3609	c.3609C>G	c.(3607-3609)GCC>GCG	p.A1203A		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1203					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CATCCGCAGCCCAGACCATCC	0.736													0	0	0	0.00499	0	16	20										G	104642734	C	G	104642734	2	3	89	1	0	0	0	0	0	0	0	1	8294	610	22	4		4	KIF26A	14	104642734	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1076094	104642734	2706806	325	26903										
INF2	64423	broad.mit.edu	37	chr14	105174812	105174812	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtccctgagcagccccgacgCcgaggctgtggagcccgact	14	16	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:105174812C>A	uc001ypb.2	+	9	1918	c.1775C>A	c.(1774-1776)GCC>GAC	p.A592D	INF2_uc010tyi.1_Missense_Mutation_p.A592D|INF2_uc001ypc.2_Missense_Mutation_p.A592D|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	592	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		AGCCCCGACGCCGAGGCTGTG	0.682											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.34159e-35	0.01441	1.80724e-35	61	62										A	105174812	C	A	105174812	3	1	89	1	0	0	0	0	1	0	0	0	7734	739	26	4	1809	4	INF2	14	105174812	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	532078	105174812	2174728	326	26904										
KIAA0284	283638	broad.mit.edu	37	chr14	105354104	105354104	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctggccatgccccggaagcgGgccggctccttcacagggac	14	16	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:105354104G>C	uc010axb.2	+	12	3752	c.3528G>C	c.(3526-3528)CGG>CGC	p.R1176R	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Silent_p.R1106R|KIAA0284_uc001yps.2_Silent_p.R1082R|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1176						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CCCGGAAGCGGGCCGGCTCCT	0.697													0	0	0	0.008291	0	10	6										C	105354104	G	C	105354104	2	2	89	1	0	0	0	0	0	0	0	1	8166	1219	43	4		4	KIAA0284	14	105354104	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	179292	105354104	1995436	327	26905										
OTUD7A	161725	broad.mit.edu	37	chr15	31776332	31776332	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agccgatcatctcctcgtggAactggtgccggtggctggtg	15	11	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:31776332A>G	uc001zfq.2	-	11	2039	c.1946T>C	c.(1945-1947)TTC>TCC	p.F649S	OTUD7A_uc001zfr.2_Missense_Mutation_p.F656S	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	649						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CTCCTCGTGGAACTGGTGCCG	0.592													0	0	0	0.012319	0	17	32										G	31776332	A	G	31776332	3	3	89	1	0	0	0	0	1	0	0	0	11318	246	9	5	838	5	OTUD7A	15	31776332	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08		31776332	70755060	328	26906										
EIF3J	8669	broad.mit.edu	37	chr15	44829435	44829435	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgggggactcggactcctggGgtgaggagaagttgctgggg	21	7	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:44829435G>C	uc001ztv.2	+	1	170	c.43G>C	c.(43-45)GAC>CAC	p.D15H	uc001ztu.2_5'Flank|EIF3J_uc010ueg.1_Missense_Mutation_p.D15H|EIF3J_uc001ztw.2_Missense_Mutation_p.D15H	NM_003758	NP_003749	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3,	15	Sufficient for interaction with EIF3B.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		GGACTCCTGGGGTGAGGAGAA	0.483													0	0	0	0.004482	0	8	10										C	44829435	G	C	44829435	3	2	89	1	0	0	0	0	1	0	0	0	5020	1246	43	4	45	4	EIF3J	15	44829435	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	13053103	44829435	57701957	329	26907										
SLC12A1	6557	broad.mit.edu	37	chr15	48561931	48561931	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctggaggaaagctcccttgaCagagattgagaactacgtgg	13	8	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:48561931C>A	uc001zwn.3	+	19	2588	c.2372C>A	c.(2371-2373)ACA>AAA	p.T791K	SLC12A1_uc010uew.1_Missense_Mutation_p.T597K|SLC12A1_uc010bem.2_Missense_Mutation_p.T791K|SLC12A1_uc001zwq.3_Missense_Mutation_p.T562K|SLC12A1_uc001zwr.3_Missense_Mutation_p.T518K	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	791					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCTCCCTTGACAGAGATTGAG	0.408													1	0	4.3838e-07	0.016723	4.58194e-07	13	16										A	48561931	C	A	48561931	3	1	89	1	0	0	0	0	1	0	0	0	14382	478	17	4	2542	4	SLC12A1	15	48561931	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3732496	48561931	53969461	330	26908										
ATP8B4	79895	broad.mit.edu	37	chr15	50211048	50211048	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	caagttaccttgtttgtctcCtgttaggacccagatcttaa	7	10	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:50211048C>A	uc001zxu.2	-	19	2165	c.2023G>T	c.(2023-2025)GGA>TGA	p.G675*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.G548*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.G485*|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	675	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGTTTGTCTCCTGTTAGGACC	0.343													1	0	1.90571e-15	0.019004	2.20808e-15	33	45										A	50211048	C	A	50211048	4	1	89	1	0	0	0	0	0	1	0	0	1197	690	24	4	1595	4	ATP8B4	15	50211048	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1649117	50211048	52320344	331	26909										
UNC13C	440279	broad.mit.edu	37	chr15	54803976	54803976	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatcttgatgaacaatattcAacaattgcgggtccagctgg	9	8	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:54803976A>G	uc002ack.2	+	22	5405	c.5405A>G	c.(5404-5406)CAA>CGA	p.Q1802R		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1802					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AACAATATTCAACAATTGCGG	0.313													0	0	0	0.010729	0	11	5										G	54803976	A	G	54803976	3	3	89	1	0	0	0	0	1	0	0	0	16983	130	5	5	5491	5	UNC13C	15	54803976	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	4592928	54803976	47727416	332	26910										
NEDD4	4734	broad.mit.edu	37	chr15	56152722	56152722	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gacggtggaggtgatgggaaGgcctggttgctatacatggt	18	5	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:56152722G>T	uc002adj.2	-	7	2400	c.2100C>A	c.(2098-2100)GCC>GCA	p.A700A	NEDD4_uc002adl.2_Silent_p.A281A|NEDD4_uc002adi.2_Silent_p.A628A|NEDD4_uc010ugj.1_Silent_p.A684A|NEDD4_uc010bfm.2_Silent_p.A683A|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	700	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GTGATGGGAAGGCCTGGTTGC	0.423													1	0	5.50884e-06	0.013537	5.68291e-06	11	66										T	56152722	G	T	56152722	2	4	89	1	0	0	0	0	0	0	0	1	10310	987	35	4		4	NEDD4	15	56152722	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1348746	56152722	46378670	333	26911										
VPS13C	54832	broad.mit.edu	37	chr15	62146695	62146695	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgagaagtctcactgatgaCtgcttcatcaatttttgctg	8	9	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:62146695C>A	uc002agz.2	-	85	11297	c.11223G>T	c.(11221-11223)CAG>CAT	p.Q3741H	VPS13C_uc002aha.2_Missense_Mutation_p.Q3698H	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3741					protein localization					ovary(2)	2						TCACTGATGACTGCTTCATCA	0.398													1	0	1.37143e-49	0.01441	1.92209e-49	112	135										A	62146695	C	A	62146695	3	1	89	1	0	0	0	0	1	0	0	0	17188	564	20	4	42	4	VPS13C	15	62146695	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5993973	62146695	40384697	334	26912										
CSPG4	1464	broad.mit.edu	37	chr15	75981330	75981330	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acgctcacatcctgccccacGgcattggtctccaccgacag	8	18	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:75981330G>A	uc002baw.2	-	3	2169	c.2076C>T	c.(2074-2076)GCC>GCT	p.A692A		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	692	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCTGCCCCACGGCATTGGTCT	0.662													0	0	0	0.01441	0	57	84										A	75981330	G	A	75981330	2	1	89	1	0	0	0	0	0	0	0	1	3960	1103	39	2		2	CSPG4	15	75981330	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	13834635	75981330	26550062	335	26913										
ZNF774	342132	broad.mit.edu	37	chr15	90897897	90897897	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgatgacgcttgataatgtGgctggggacttcagggaaga	15	6	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:90897897G>C	uc002bpk.3	+	2	191	c.5G>C	c.(4-6)TGG>TCG	p.W2S		NM_001004309	NP_001004309	Q6NX45	ZN774_HUMAN	zinc finger protein 774	2	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TTGATAATGTGGCTGGGGACT	0.483													0	0	0	0.008291	0	10	11										C	90897897	G	C	90897897	3	2	89	1	0	0	0	0	1	0	0	0	18144	1357	47	4	7	4	ZNF774	15	90897897	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	14916567	90897897	11633495	336	26914										
RCCD1	91433	broad.mit.edu	37	chr15	91500713	91500713	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctggacgctgctggccaggtGttctcctggggcgggggcag	19	11	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:91500713G>A	uc002bqj.2	+	4	817	c.537G>A	c.(535-537)GTG>GTA	p.V179V	RCCD1_uc002bqk.2_Silent_p.V179V|RCCD1_uc002bql.2_Silent_p.V179V|RCCD1_uc010bob.2_Intron	NM_033544	NP_291022	A6NED2	RCCD1_HUMAN	RCC1 domain containing 1	179	RCC1 2.			RLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLL DAAGQVFSWGGGR -> GGAAGGLVRLRFLRLRAGAGLRTR APGAQPQSAAGGRRHLPRERELELHRFRDP (in Ref. 3; AAI13827).							0	Lung NSC(78;0.0987)|all_lung(78;0.175)		Lung(145;0.189)			CTGGCCAGGTGTTCTCCTGGG	0.706													0	0	0	0.009096	0	3	5										A	91500713	G	A	91500713	2	1	89	1	0	0	0	0	0	0	0	1	13175	1364	48	2		2	RCCD1	15	91500713	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	602816	91500713	11030679	337	26915										
NR2F2	7026	broad.mit.edu	37	chr15	96877679	96877679	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcgccccgctcctggccgccGccggcctgcatgcttcgccc	11	22	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:96877679G>T	uc010uri.1	+	2	2041	c.817G>T	c.(817-819)GCC>TCC	p.A273S	NR2F2_uc002btp.2_Missense_Mutation_p.A140S|NR2F2_uc010urj.1_Missense_Mutation_p.A120S|NR2F2_uc010urk.1_Missense_Mutation_p.A120S	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	273	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			CCTGGCCGCCGCCGGCCTGCA	0.652													1	0	4.65686e-17	0.017118	5.51079e-17	36	50										T	96877679	G	T	96877679	3	4	89	1	0	0	0	0	1	0	0	0	10628	1087	38	4	870	4	NR2F2	15	96877679	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	5376966	96877679	5653713	338	26916										
SOX8	30812	broad.mit.edu	37	chr16	1034810	1034810	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgccggccggtggacagcggGcgccagaacatcgacttcag	15	14	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:1034810G>T	uc002ckn.2	+	3	880	c.765G>T	c.(763-765)GGG>GGT	p.G255G		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	255					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				TGGACAGCGGGCGCCAGAACA	0.682													1	0	3.65163e-15	0.00632	4.2222e-15	28	21										T	1034810	G	T	1034810	2	4	89	1	0	0	0	0	0	0	0	1	14957	1190	42	4		4	SOX8	16	1034810	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		1034810	89319943	339	26917										
PKD1	5310	broad.mit.edu	37	chr16	2168842	2168842	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcaaacgggttcccactcaGgtttctgcagggcaggggca	13	12	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:2168842G>A	uc002cos.1	-	4	573	c.364C>T	c.(364-366)CTG>TTG	p.L122L	PKD1_uc002cot.1_Silent_p.L122L	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	122	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TTCCCACTCAGGTTTCTGCAG	0.682													0	0	0	0.006214	0	8	38										A	2168842	G	A	2168842	2	1	89	1	0	0	0	0	0	0	0	1	11963	991	35	2		2	PKD1	16	2168842	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1134032	2168842	88185911	340	26918										
ZSCAN10	84891	broad.mit.edu	37	chr16	3140433	3140433	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggctcggggacgccctcagcCactttgacctccaaaatttc	9	15	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:3140433C>A	uc002ctv.1	-	5	925	c.837G>T	c.(835-837)GTG>GTT	p.V279V	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Silent_p.V197V|ZSCAN10_uc002ctx.1_Silent_p.V207V	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	279					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGCCCTCAGCCACTTTGACCT	0.652													1	0	1.70349e-48	0.01441	2.38145e-48	95	135										A	3140433	C	A	3140433	2	1	89	1	0	0	0	0	0	0	0	1	18224	581	21	4		4	ZSCAN10	16	3140433	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	971591	3140433	87214320	341	26919										
NLRC3	197358	broad.mit.edu	37	chr16	3613643	3613643	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggaagcagctgcacggggcgCcctgcagcagagcgaggtct	17	12	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:3613643C>A	uc010btn.2	-	5	1706	c.1295G>T	c.(1294-1296)GGC>GTC	p.G432V		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	432	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCACGGGGCGCCCTGCAGCAG	0.587													1	0	1.01871e-10	0.008871	1.11516e-10	19	19										A	3613643	C	A	3613643	3	1	89	1	0	0	0	0	1	0	0	0	10468	739	26	4	1967	4	NLRC3	16	3613643	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	473210	3613643	86741110	342	26920										
USP7	7874	broad.mit.edu	37	chr16	9014215	9014215	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cctgattaaagaaaaacttaCgcaactccatggggagcatc	8	10	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:9014215C>T	uc002czl.2	-	5	810	c.611_splice	c.e5+1	p.A204_splice	USP7_uc010uyk.1_Splice_Site_p.A105_splice|USP7_uc010uyj.1_Splice_Site_p.A105_splice|USP7_uc002czk.2_Splice_Site_p.A188_splice|USP7_uc010uyl.1_Splice_Site	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7						interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						GAAAAACTTACGCAACTCCAT	0.378													0	0	0	0.005524	0	37	51										T	9014215	C	T	9014215	5	4	89	1	0	0	0	0	0	0	1	0	17085	550	19	2	2804	2	USP7	16	9014215	Splice_Site	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5400572	9014215	81340538	343	26921										
NTAN1	123803	broad.mit.edu	37	chr16	15133844	15133844	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actggtcctcctgctaaagtTcgcgcagcacgaagctgctc	10	14	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:15133844T>A	uc002ddd.2	-	8	626	c.621A>T	c.(619-621)CGA>CGT	p.R207R	PDXDC1_uc002ddc.2_Intron|NTAN1_uc010uzo.1_Silent_p.R102R	NM_173474	NP_775745	Q96AB6	NTAN1_HUMAN	N-terminal Asn amidase	207						cytoplasm					0						CTGCTAAAGTTCGCGCAGCAC	0.443													0	0	0	0.01441	0	129	154										A	15133844	T	A	15133844	2	1	89	1	0	0	0	0	0	0	0	1	10695	1770	62	5		5	NTAN1	16	15133844	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	6119629	15133844	75220909	344	26922										
ABCC1	4363	broad.mit.edu	37	chr16	16130386	16130386	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agtgacctctggtccttaaaCaaggaggacacgtcggaaca	11	10	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:16130386C>T	uc010bvi.2	+	7	910	c.735C>T	c.(733-735)AAC>AAT	p.N245N	ABCC1_uc010bvj.2_Silent_p.N245N|ABCC1_uc010bvk.2_Silent_p.N245N|ABCC1_uc010bvl.2_Silent_p.N245N|ABCC1_uc010bvm.2_Silent_p.N245N|ABCC1_uc002del.3_Silent_p.N129N|ABCC1_uc010bvn.2_Silent_p.N108N	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	245	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTCCTTAAACAAGGAGGACA	0.532													0	0	0	0.01441	0	66	74										T	16130386	C	T	16130386	2	4	89	1	0	0	0	0	0	0	0	1	49	477	17	2		2	ABCC1	16	16130386	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	996542	16130386	74224367	345	26923										
GPR139	124274	broad.mit.edu	37	chr16	20084882	20084882	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cccaagccgcaggccgagccGggggaccaccaagacagcga	14	16	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:20084882G>T	uc002dgu.1	-	1	219	c.57C>A	c.(55-57)CCC>CCA	p.P19P	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	19	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)	2						AGGCCGAGCCGGGGGACCACC	0.697													1	0	1.2644e-06	0.010504	1.31674e-06	15	5										T	20084882	G	T	20084882	2	4	89	1	0	0	0	0	0	0	0	1	6648	1103	39	4		4	GPR139	16	20084882	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3954496	20084882	70269871	346	26924										
SCNN1B	6338	broad.mit.edu	37	chr16	23388689	23388689	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	accatctccatggctgactgGccttctgaggcctccgaggt	11	14	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:23388689G>A	uc002dln.2	+	10	1562	c.1386G>A	c.(1384-1386)TGG>TGA	p.W462*		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	462	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TGGCTGACTGGCCTTCTGAGG	0.587													0	0	0	0.00623	0	34	55										A	23388689	G	A	23388689	4	1	89	1	0	0	0	0	0	1	0	0	13928	1212	42	2	1420	2	SCNN1B	16	23388689	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3303807	23388689	66966064	347	26925										
GTF3C1	2975	broad.mit.edu	37	chr16	27475764	27475764	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tcccgctgcagcggtgtcttCaagagctgggggtggagatg	17	9	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:27475764C>T	uc002dov.1	-	34	5789	c.5749G>A	c.(5749-5751)GAA>AAA	p.E1917K	GTF3C1_uc002dou.2_Missense_Mutation_p.E1917K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1917						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCGGTGTCTTCAAGAGCTGGG	0.652													0	0	0	0.01441	0	107	104										T	27475764	C	T	27475764	3	4	89	1	0	0	0	0	1	0	0	0	6872	835	29	1	596	1	GTF3C1	16	27475764	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4087075	27475764	62878989	348	26926										
GTF3C1	2975	broad.mit.edu	37	chr16	27556790	27556790	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggtagacatcctccaaagcCaccgggtccctcctagactc	9	16	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:27556790C>G	uc002dov.1	-	2	316	c.276G>C	c.(274-276)GTG>GTC	p.V92V	GTF3C1_uc002dou.2_Silent_p.V92V	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	92						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCTCCAAAGCCACCGGGTCCC	0.423													0	0	0	0.021022	0	37	39										G	27556790	C	G	27556790	2	3	89	1	0	0	0	0	0	0	0	1	6872	581	21	4		4	GTF3C1	16	27556790	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	81026	27556790	62797963	349	26927										
CLN3	1201	broad.mit.edu	37	chr16	28493802	28493802	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcacccctcacttacaagtCcctggttaatgaaatactcg	6	13	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:28493802C>A	uc002dpo.2	-	11	1225	c.902G>T	c.(901-903)GGA>GTA	p.G301V	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.G223V|CLN3_uc010vcu.1_Missense_Mutation_p.G201V|CLN3_uc002dpn.2_Missense_Mutation_p.G202V|CLN3_uc002dpm.2_Missense_Mutation_p.G247V|CLN3_uc010vcv.1_Missense_Mutation_p.G277V|CLN3_uc010byd.2_Missense_Mutation_p.G301V|CLN3_uc002dpp.2_Missense_Mutation_p.G301V|CLN3_uc002dpt.1_Missense_Mutation_p.G201V|CLN3_uc002dpq.1_Missense_Mutation_p.G253V|CLN3_uc010bye.1_Intron|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.G174V|CLN3_uc002dpu.1_Missense_Mutation_p.G199V|CLN3_uc002dpw.1_Missense_Mutation_p.G148V|CLN3_uc010vcw.1_Missense_Mutation_p.G247V|CLN3_uc002dqa.2_3'UTR|CLN3_uc010vcx.1_3'UTR|CLN3_uc002dpx.1_Missense_Mutation_p.G178V|CLN3_uc002dpy.1_Missense_Mutation_p.G145V	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	301					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						ACTTACAAGTCCCTGGTTAAT	0.542													1	0	9.16793e-09	0.00499	9.76622e-09	15	102										A	28493802	C	A	28493802	3	1	89	1	0	0	0	0	1	0	0	0	3543	855	30	3	434	3	CLN3	16	28493802	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	937012	28493802	61860951	350	26928										
RABEP2	79874	broad.mit.edu	37	chr16	28925724	28925724	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagggaggagctgctgccgaCcccaccgccaagggagaagg	16	13	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:28925724C>A	uc002drq.2	-	5	775	c.727G>T	c.(727-729)GTC>TTC	p.V243F	uc010vct.1_Intron|RABEP2_uc010vdf.1_Missense_Mutation_p.V172F|RABEP2_uc010byn.2_Missense_Mutation_p.V243F|RABEP2_uc002drr.2_Missense_Mutation_p.V243F	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	243					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CTGCTGCCGACCCCACCGCCA	0.672													1	0	3.76114e-14	0.019004	4.29512e-14	37	32										A	28925724	C	A	28925724	3	1	89	1	0	0	0	0	1	0	0	0	12962	507	18	4	1018	4	RABEP2	16	28925724	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	431922	28925724	61429029	351	26929										
SEPT1	1731	broad.mit.edu	37	chr16	30392504	30392504	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcatccgctttgccaatgaCtgggatgatgttgactttct	10	9	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:30392504C>A	uc002dxy.2	-	7	689	c.502G>T	c.(502-504)GTC>TTC	p.V168F	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_5'UTR|SEPT1_uc010veq.1_3'UTR	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	168					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TTGCCAATGACTGGGATGATG	0.582													1	0	4.96213e-28	0.01441	6.41954e-28	56	92										A	30392504	C	A	30392504	3	1	89	1	0	0	0	0	1	0	0	0	14059	565	20	4	625	4	SEPT1	16	30392504	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1466780	30392504	59962249	352	26930										
ZNF668	79759	broad.mit.edu	37	chr16	31073488	31073488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agcccttgccgcaggccgggCagcggtagggcttctgtgcc	16	14	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:31073488C>T	uc010caf.2	-	3	1118	c.761G>A	c.(760-762)TGC>TAC	p.C254Y	ZNF668_uc002eao.2_Missense_Mutation_p.C254Y	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	254	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GCAGGCCGGGCAGCGGTAGGG	0.697													0	0	0	0.021022	0	35	39										T	31073488	C	T	31073488	3	4	89	1	0	0	0	0	1	0	0	0	18072	710	25	2	1102	2	ZNF668	16	31073488	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	680984	31073488	59281265	353	26931										
ZNF646	9726	broad.mit.edu	37	chr16	31088322	31088322	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaacttcacagggggccaggAgcccacccagtcccctcctg	11	17	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:31088322A>G	uc002eap.2	+	2	966	c.677A>G	c.(676-678)GAG>GGG	p.E226G	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						GGGGGCCAGGAGCCCACCCAG	0.602													0	0	0	0.006999	0	39	42										G	31088322	A	G	31088322	3	3	89	1	0	0	0	0	1	0	0	0	18059	304	11	5	679	5	ZNF646	16	31088322	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	14834	31088322	59266431	354	26932										
MYLK3	91807	broad.mit.edu	37	chr16	46764580	46764580	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgacgctcactacccggtgtTcaaaaggagctggtggggcc	14	11	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:46764580T>C	uc002eei.3	-	5	1609	c.1493A>G	c.(1492-1494)GAA>GGA	p.E498G	MYLK3_uc010vge.1_Missense_Mutation_p.E157G|MYLK3_uc002eej.1_Missense_Mutation_p.E157G	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	498					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TACCCGGTGTTCAAAAGGAGC	0.602													0	0	0	0.01441	0	46	92										C	46764580	T	C	46764580	3	2	89	1	0	0	0	0	1	0	0	0	10058	1783	62	5	1002	5	MYLK3	16	46764580	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	15676258	46764580	43590173	355	26933										
ABCC11	85320	broad.mit.edu	37	chr16	48248887	48248887	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaacaaggttatacttgtcaGgctctggacaagcccgcact	10	11	2	0	rs142830864		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:48248887G>C	uc002eff.1	-	8	1503	c.1153C>G	c.(1153-1155)CTG>GTG	p.L385V	ABCC11_uc002efg.1_Missense_Mutation_p.L385V|ABCC11_uc002efh.1_Missense_Mutation_p.L385V|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	385	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATACTTGTCAGGCTCTGGACA	0.448									Cerumen_Type				0	0	0	0.008361	0	31	30										C	48248887	G	C	48248887	3	2	89	1	0	0	0	0	1	0	0	0	51	991	35	4	3083	4	ABCC11	16	48248887	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1484307	48248887	42105866	356	26934										
C16orf78	123970	broad.mit.edu	37	chr16	49407936	49407936	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgctgaagataggcgcatgtCtgacctcacctgtgtgctgg	13	10	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:49407936C>A	uc002efr.2	+	1	129	c.86C>A	c.(85-87)TCT>TAT	p.S29Y		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	29										central_nervous_system(1)	1						AGGCGCATGTCTGACCTCACC	0.468													1	0	3.94839e-29	0.01441	5.20512e-29	63	55										A	49407936	C	A	49407936	3	1	89	1	0	0	0	0	1	0	0	0	1835	913	32	3	88	3	C16orf78	16	49407936	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1159049	49407936	40946817	357	26935										
MMP2	4313	broad.mit.edu	37	chr16	55523725	55523725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgaccgcaagtggggcttctGccctgaccaaggtacgaggc	14	12	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:55523725G>A	uc002ehz.3	+	7	1480	c.1169G>A	c.(1168-1170)TGC>TAC	p.C390Y	MMP2_uc010vhd.1_Missense_Mutation_p.C314Y|MMP2_uc010ccc.2_Missense_Mutation_p.C340Y	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	390	Fibronectin type-II 3.|Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TGGGGCTTCTGCCCTGACCAA	0.572													0	0	0	0.021523	0	25	37										A	55523725	G	A	55523725	3	1	89	1	0	0	0	0	1	0	0	0	9658	1319	46	2	1202	2	MMP2	16	55523725	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	6115789	55523725	34831028	358	26936										
PRSS54	221191	broad.mit.edu	37	chr16	58314503	58314503	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agtgaggacaggggagggccGgccctctcagccttggatgt	17	10	1	1	rs151211769		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:58314503G>A	uc002enf.2	-	7	1208	c.813C>T	c.(811-813)GCC>GCT	p.A271A	PRSS54_uc002eng.2_Silent_p.A271A|PRSS54_uc010vie.1_Silent_p.A172A|CCDC113_uc002ene.2_3'UTR|CCDC113_uc010vid.1_3'UTR	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	271					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGGGAGGGCCGGCCCTCTCAG	0.527													0	0	0	0.013726	0	33	29										A	58314503	G	A	58314503	2	1	89	1	0	0	0	0	0	0	0	1	12633	1103	39	2		2	PRSS54	16	58314503	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2790778	58314503	32040250	359	26937										
CDH5	1003	broad.mit.edu	37	chr16	66436895	66436895	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggcgacggccccccctacgaCacgctgcacatctacggcta	10	18	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:66436895C>A	uc002eom.3	+	12	2334	c.2178C>A	c.(2176-2178)GAC>GAA	p.D726E		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	726	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CCCCCTACGACACGCTGCACA	0.667													1	0	3.5997e-14	0.014323	4.12775e-14	23	23										A	66436895	C	A	66436895	3	1	89	1	0	0	0	0	1	0	0	0	3113	477	17	4	2220	4	CDH5	16	66436895	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	8122392	66436895	23917858	360	26938										
SF3B3	23450	broad.mit.edu	37	chr16	70605036	70605036	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catgtggaaatgcacctgcgGtctgaacatccccctctctg	9	14	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:70605036G>T	uc002ezf.2	+	25	3658	c.3447G>T	c.(3445-3447)CGG>CGT	p.R1149R		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1149					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TGCACCTGCGGTCTGAACATC	0.498													1	0	8.74965e-44	0.01441	1.20199e-43	109	113										T	70605036	G	T	70605036	2	4	89	1	0	0	0	0	0	0	0	1	14152	1248	44	4		4	SF3B3	16	70605036	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4168141	70605036	19749717	361	26939										
MARVELD3	91862	broad.mit.edu	37	chr16	71668682	71668682	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gttaggaagctaaaagagaaGccagcagaaatgtttgaatt	11	4	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:71668682G>T	uc002fat.2	+	3	1245	c.1182G>T	c.(1180-1182)AAG>AAT	p.K394N	MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 2	394	Cytoplasmic (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				TAAAAGAGAAGCCAGCAGAAA	0.493													1	0	1.07637e-12	0.021022	1.21173e-12	37	43										T	71668682	G	T	71668682	3	4	89	1	0	0	0	0	1	0	0	0	9319	962	34	4	1192	4	MARVELD3	16	71668682	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1063646	71668682	18686071	362	26940										
CLEC18B	497190	broad.mit.edu	37	chr16	74452026	74452026	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggctgtaccgctgcccctcTgcaaaccacaggctgaccac	9	17	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:74452026T>A	uc002fct.2	-	3	587	c.387A>T	c.(385-387)GCA>GCT	p.A129A	CLEC18B_uc002fcu.2_Silent_p.A129A|CLEC18B_uc010vmu.1_Intron|CLEC18B_uc010vmw.1_Silent_p.A129A	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	129	SCP.					extracellular region	sugar binding				0						GCTGCCCCTCTGCAAACCACA	0.662													0	0	0	0.007291	0	29	36										A	74452026	T	A	74452026	2	1	89	1	0	0	0	0	0	0	0	1	3503	1567	55	5		5	CLEC18B	16	74452026	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	2783344	74452026	15902727	363	26941										
PKD1L2	114780	broad.mit.edu	37	chr16	81232364	81232364	+	Frame_Shift_Del	DEL	C	C	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agtccagccacctcaaaggtCagctcttccggggtgccctg							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:81232364delC	uc002fgh.1	-	7	1446	c.1446delG	c.(1444-1446)CTGfs	p.L482fs	PKD1L2_uc002fgj.2_Frame_Shift_Del_p.L482fs	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	482	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCTCAAAGGTCAGCTCTTCCG	0.562																		65	61	---	---								-	81232364	C	-	81232364	7	5	89	1	0	1	0	1	0	0	0	0	11965	813	29	0	6150	0	PKD1L2	16	81232364	Frame_Shift_Del	DEL	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6780338	81232364	9122389	364	26942										
TP53	7157	broad.mit.edu	37	chr17	7578455	7578455	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgcttgtagatggccatggCgcggacgcgggtgccgggcg	19	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:7578455C>G	uc002gim.2	-	5	669	c.475G>C	c.(475-477)GCC>CCC	p.A159P	TP53_uc002gig.1_Missense_Mutation_p.A159P|TP53_uc002gih.2_Missense_Mutation_p.A159P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27P|TP53_uc010cng.1_Missense_Mutation_p.A27P|TP53_uc002gii.1_Missense_Mutation_p.A27P|TP53_uc010cnh.1_Missense_Mutation_p.A159P|TP53_uc010cni.1_Missense_Mutation_p.A159P|TP53_uc002gij.2_Missense_Mutation_p.A159P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66P|TP53_uc002gio.2_Missense_Mutation_p.A27P|TP53_uc010vug.1_Missense_Mutation_p.A120P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R158fs*11(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCCATGGCGCGGACGCGG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	52	9										G	7578455	C	G	7578455	3	3	89	1	0	0	0	0	1	0	0	0	16378	768	27	4	823	4	TP53	17	7578455	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		7578455	73616755	365	26943										
MYH4	4622	broad.mit.edu	37	chr17	10353854	10353854	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	caacctcactgttggccttgGacattcccctctgcagctca	7	16	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:10353854G>C	uc002gmn.2	-	30	4208	c.4097C>G	c.(4096-4098)TCC>TGC	p.S1366C	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1366	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTGGCCTTGGACATTCCCCT	0.602													0	0	0	0.01441	0	102	9										C	10353854	G	C	10353854	3	2	89	1	0	0	0	0	1	0	0	0	10037	1174	41	1	1766	1	MYH4	17	10353854	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2775399	10353854	70841356	366	26944										
SREBF1	6720	broad.mit.edu	37	chr17	17719174	17719174	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggaaggggtaagagagcacCtgggttcccggccaagctgt	17	9	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:17719174C>G	uc002gru.1	-	12	2577	c.2383G>C	c.(2383-2385)GTG>CTG	p.V795L	SREBF1_uc002grp.1_Missense_Mutation_p.V414L|SREBF1_uc002grq.1_Missense_Mutation_p.V314L|SREBF1_uc002grr.1_Missense_Mutation_p.V541L|SREBF1_uc002grs.1_Missense_Mutation_p.V771L|SREBF1_uc002grt.1_Missense_Mutation_p.V825L|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	795	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						AAGAGAGCACCTGGGTTCCCG	0.627													0	0	0	0.00308	0	8	21										G	17719174	C	G	17719174	3	3	89	1	0	0	0	0	1	0	0	0	15140	695	24	4	1092	4	SREBF1	17	17719174	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7365320	17719174	63476036	367	26945										
TOP3A	7156	broad.mit.edu	37	chr17	18181198	18181198	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggatccctgggcctggtgggCatcccagggaggcgcccagg	18	13	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:18181198C>A	uc002gsx.1	-	18	2847	c.2618G>T	c.(2617-2619)TGC>TTC	p.C873F	TOP3A_uc010cpz.1_Missense_Mutation_p.C325F|TOP3A_uc010vxr.1_Missense_Mutation_p.C403F|TOP3A_uc002gsw.1_Missense_Mutation_p.C325F|TOP3A_uc010vxs.1_Missense_Mutation_p.C771F	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	873	2 X 27 AA approximate repeats.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GCCTGGTGGGCATCCCAGGGA	0.642													1	0	2.14255e-21	0.01441	2.64836e-21	57	55										A	18181198	C	A	18181198	3	1	89	1	0	0	0	0	1	0	0	0	16364	710	25	4	395	4	TOP3A	17	18181198	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	462024	18181198	63014012	368	26946										
RNF112	7732	broad.mit.edu	37	chr17	19319264	19319264	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggggtgctgtgggggccgggCtcatgggcctggcagggggc	24	9	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:19319264C>T	uc010vyw.1	+	14	1871	c.1672C>T	c.(1672-1674)CTC>TTC	p.L558F	RNF112_uc010vyv.1_Missense_Mutation_p.L559F	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	558							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						GGGGGCCGGGCTCATGGGCCT	0.692													0	0	0	0.00308	0	8	11										T	19319264	C	T	19319264	3	4	89	1	0	0	0	0	1	0	0	0	13426	797	28	2	1436	2	RNF112	17	19319264	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1138066	19319264	61875946	369	26947										
RDM1	201299	broad.mit.edu	37	chr17	34251642	34251642	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccataggctcctccaccaaGccaatgccaggactcctgca	7	17	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:34251642G>A	uc002hkh.2	-	4	583	c.534C>T	c.(532-534)GGC>GGT	p.G178G	RDM1_uc010cty.2_Intron|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Silent_p.G155G|RDM1_uc002hkg.3_Silent_p.G155G|RDM1_uc010cub.2_Intron|RDM1_uc010cud.2_Silent_p.G178G|RDM1_uc010cuf.2_Intron|RDM1_uc010cue.2_Intron|RDM1_uc010cug.2_Intron|RDM1_uc010cuc.2_Intron|RDM1_uc010wco.1_Intron|RDM1_uc010wcp.1_Silent_p.G155G|RDM1_uc002hki.2_Silent_p.G178G	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	178					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CCTCCACCAAGCCAATGCCAG	0.483								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.01441	0	113	10										A	34251642	G	A	34251642	2	1	89	1	0	0	0	0	0	0	0	1	13197	958	34	2		2	RDM1	17	34251642	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	14932378	34251642	46943568	370	26948										
HSD17B1	3292	broad.mit.edu	37	chr17	40704977	40704977	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccgcaccgtggtgctcatcaCcggctgttcctcgggcatcg	12	16	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:40704977C>G	uc002hzw.2	+	1	994	c.26C>G	c.(25-27)ACC>AGC	p.T9S	HSD17B1_uc002hzx.2_Missense_Mutation_p.T9S|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_Missense_Mutation_p.V202L|HSD17B1_uc010cyi.2_Missense_Mutation_p.T9S	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	9					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	GTGCTCATCACCGGCTGTTCC	0.647													0	0	0	0.01441	0	55	4										G	40704977	C	G	40704977	3	3	89	1	0	0	0	0	1	0	0	0	7378	507	18	4	28	4	HSD17B1	17	40704977	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	6453335	40704977	40490233	371	26949										
ACBD4	79777	broad.mit.edu	37	chr17	43220992	43220992	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actatcttgctgtgccctgaGccttcctagggtttagaaga	10	10	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:43220992G>A	uc010wjj.1	+	12	1479	c.1010G>A	c.(1009-1011)AGC>AAC	p.S337N	ACBD4_uc002iie.2_Missense_Mutation_p.S337N|ACBD4_uc002iif.2_3'UTR|ACBD4_uc002iic.2_3'UTR|ACBD4_uc010dae.2_Missense_Mutation_p.S259N	NM_001135704	NP_001129176	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	Error:Variant_position_missing_in_Q8NC06_after_alignment							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						TGTGCCCTGAGCCTTCCTAGG	0.542													0	0	0	0.01441	0	66	0										A	43220992	G	A	43220992	3	1	89	1	0	0	0	0	1	0	0	0	124	971	34	2	1076	2	ACBD4	17	43220992	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2516015	43220992	37974218	372	26950										
CBX1	10951	broad.mit.edu	37	chr17	46152410	46152410	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctccactggagtctgtagctCcaataatccgctccggctcc	8	16	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:46152410C>G	uc002ind.3	-	4	852	c.371G>C	c.(370-372)GGA>GCA	p.G124A	CBX1_uc002ine.3_Missense_Mutation_p.G124A	NM_006807	NP_006798	P83916	CBX1_HUMAN	heterochromatin protein 1-beta	124	Chromo 2; shadow subtype.					nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding				0						GTCTGTAGCTCCAATAATCCG	0.453													0	0	0	0.01441	0	87	87										G	46152410	C	G	46152410	3	3	89	1	0	0	0	0	1	0	0	0	2717	855	30	1	194	1	CBX1	17	46152410	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2931418	46152410	35042800	373	26951										
SAMD14	201191	broad.mit.edu	37	chr17	48195665	48195665	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taaactgctgtccagtctggCcgtctctggcacagccaagt	10	13	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:48195665C>T	uc002iqg.2	-	3	369	c.70G>A	c.(70-72)GCC>ACC	p.A24T	SAMD14_uc002iqd.2_5'Flank|SAMD14_uc002iqe.2_5'UTR|SAMD14_uc002iqf.2_Missense_Mutation_p.A24T	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	24											0						TCCAGTCTGGCCGTCTCTGGC	0.662													0	0	0	0.01441	0	95	83										T	48195665	C	T	48195665	3	4	89	1	0	0	0	0	1	0	0	0	13819	739	26	2	1303	2	SAMD14	17	48195665	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2043255	48195665	32999545	374	26952										
COL1A1	1277	broad.mit.edu	37	chr17	48269225	48269225	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggggaccttgcacaccacgcTcgccagggaaacctctctcg	11	16	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:48269225T>C	uc002iqm.2	-	31	2177	c.2051A>G	c.(2050-2052)GAG>GGG	p.E684G		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	684	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	CACACCACGCTCGCCAGGGAA	0.642			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						0	0	0	0.012319	0	19	23										C	48269225	T	C	48269225	3	2	89	1	0	0	0	0	1	0	0	0	3677	1551	54	5	2427	5	COL1A1	17	48269225	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	73560	48269225	32925985	375	26953										
OR4D1	26689	broad.mit.edu	37	chr17	56232574	56232574	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcttagggttttcacagacCcaagagctccagaaattcct	7	12	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:56232574C>G	uc010wno.1	+	1	60	c.60C>G	c.(58-60)ACC>ACG	p.T20T	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCACAGACCCAAGAGCTCC	0.453													0	0	0	0.01441	0	113	97										G	56232574	C	G	56232574	2	3	89	1	0	0	0	0	0	0	0	1	11053	610	22	4		4	OR4D1	17	56232574	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7963349	56232574	24962636	376	26954										
TANC2	26115	broad.mit.edu	37	chr17	61278265	61278265	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgccaaggactgcagctatgGggctgttactagtccaacct	11	11	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:61278265G>A	uc002jal.3	+	5	517	c.494G>A	c.(493-495)GGG>GAG	p.G165E	TANC2_uc010wpe.1_Missense_Mutation_p.G75E	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	165							binding			ovary(2)	2						TGCAGCTATGGGGCTGTTACT	0.468													0	0	0	0.01441	0	127	78										A	61278265	G	A	61278265	3	1	89	1	0	0	0	0	1	0	0	0	15542	1232	43	2	512	2	TANC2	17	61278265	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	5045691	61278265	19916945	377	26955										
RGS9	8787	broad.mit.edu	37	chr17	63221386	63221386	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctgtcaccgagagcagcgaGgcctccctcgacacctcctg	10	17	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:63221386G>A	uc002jfe.2	+	18	1784	c.1674G>A	c.(1672-1674)GAG>GAA	p.E558E	RGS9_uc010dem.2_Silent_p.E555E|RGS9_uc002jfd.2_Silent_p.E555E|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Silent_p.E329E	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	558					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						AGAGCAGCGAGGCCTCCCTCG	0.672													0	0	0	0.01441	0	104	165										A	63221386	G	A	63221386	2	1	89	1	0	0	0	0	0	0	0	1	13313	991	35	2		2	RGS9	17	63221386	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1943121	63221386	17973824	378	26956										
SDK2	54549	broad.mit.edu	37	chr17	71426748	71426748	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggggcttggtgatgcgggtCcgagctgaaagatacagcgg	19	7	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:71426748C>T	uc010dfm.2	-	12	1485	c.1485G>A	c.(1483-1485)CGG>CGA	p.R495R	SDK2_uc010dfn.2_Silent_p.R174R	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	495	Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TGATGCGGGTCCGAGCTGAAA	0.587													0	0	0	0.004672	0	3	21										T	71426748	C	T	71426748	2	4	89	1	0	0	0	0	0	0	0	1	13969	842	30	1		1	SDK2	17	71426748	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	8205362	71426748	9768462	379	26957										
NAT9	26151	broad.mit.edu	37	chr17	72769175	72769175	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catccagcacaatgaaggtaCactctgaggaggaggtgaca	12	9	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:72769175C>A	uc002jlq.2	-	4	268	c.194G>T	c.(193-195)TGT>TTT	p.C65F	NAT9_uc002jlr.2_Missense_Mutation_p.C64F	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9	65	N-acetyltransferase.					protein complex	N-acetyltransferase activity				0						AATGAAGGTACACTCTGAGGA	0.567													1	0	1.99505e-19	0.012213	2.41232e-19	29	15										A	72769175	C	A	72769175	3	1	89	1	0	0	0	0	1	0	0	0	10182	478	17	4	445	4	NAT9	17	72769175	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1342427	72769175	8426035	380	26958										
FBF1	85302	broad.mit.edu	37	chr17	73914079	73914079	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaggtggtgaggtgcgaggcCtccacgcgggaggacaactc	18	10	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:73914079C>A	uc002jqc.2	-	21	2548	c.2274G>T	c.(2272-2274)GAG>GAT	p.E758D	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E749D|FBF1_uc002jqd.1_Missense_Mutation_p.E759D|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_Missense_Mutation_p.E69D	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	758											0						GGTGCGAGGCCTCCACGCGGG	0.657													1	0	1.42536e-11	0.004656	1.5885e-11	24	43										A	73914079	C	A	73914079	3	1	89	1	0	0	0	0	1	0	0	0	5695	680	24	4	1163	4	FBF1	17	73914079	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1144904	73914079	7281131	381	26959										
C17orf56	146705	broad.mit.edu	37	chr17	79207838	79207838	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccgtgcagaggatctgggggCcctgcaaaagctgcagaaca	14	11	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:79207838C>G	uc002jzu.1	-	5	340	c.318G>C	c.(316-318)GGG>GGC	p.G106G	C17orf56_uc002jzr.1_5'Flank|C17orf56_uc002jzs.1_5'UTR|C17orf56_uc002jzt.1_5'UTR|C17orf56_uc002jzv.1_5'UTR	NM_144679	NP_653280	Q96N21	CQ056_HUMAN	hypothetical protein LOC146705	106						integral to membrane					0	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GATCTGGGGGCCCTGCAAAAG	0.677													0	0	0	0.00623	0	32	29										G	79207838	C	G	79207838	2	3	89	1	0	0	0	0	0	0	0	1	1864	726	26	4		4	C17orf56	17	79207838	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5293759	79207838	1987372	382	26960										
P4HB	5034	broad.mit.edu	37	chr17	79801895	79801895	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctggctttgcgtattacagtTcatctttcacagctttctga	7	10	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:79801895T>C	uc002kbn.1	-	11	1717	c.1520A>G	c.(1519-1521)GAA>GGA	p.E507G	P4HB_uc002kbl.1_Missense_Mutation_p.E184G|P4HB_uc002kbm.1_Missense_Mutation_p.E184G	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	507	Prevents secretion from ER.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GTATTACAGTTCATCTTTCAC	0.612													0	0	0	0.01441	0	193	130										C	79801895	T	C	79801895	3	2	89	1	0	0	0	0	1	0	0	0	11359	1783	62	5	10	5	P4HB	17	79801895	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	594057	79801895	1393315	383	26961										
DSC2	1824	broad.mit.edu	37	chr18	28669557	28669557	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgggccgtgtcagattgaaCctagaaagtagatattatat	10	5	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:28669557C>G	uc002kwl.3	-	5	929	c.475G>C	c.(475-477)GTT>CTT	p.V159L	DSC2_uc002kwk.3_Missense_Mutation_p.V159L	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	159	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCAGATTGAACCTAGAAAGTA	0.328													0	0	0	0.004007	0	15	20										G	28669557	C	G	28669557	3	3	89	1	0	0	0	0	1	0	0	0	4766	521	18	4	2318	4	DSC2	18	28669557	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		28669557	49407691	384	26962										
DSC1	1823	broad.mit.edu	37	chr18	28720107	28720107	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctgaataactttcactggaGggtggcattcagggccctca	11	10	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:28720107G>A	uc002kwn.2	-	10	1680	c.1418C>T	c.(1417-1419)CCT>CTT	p.P473L	DSC1_uc002kwm.2_Missense_Mutation_p.P473L	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	473	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTTCACTGGAGGGTGGCATTC	0.473													0	0	0	0.01441	0	52	61										A	28720107	G	A	28720107	3	1	89	1	0	0	0	0	1	0	0	0	4765	1000	35	2	1334	2	DSC1	18	28720107	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	50550	28720107	49357141	385	26963										
KLHL14	57565	broad.mit.edu	37	chr18	30350069	30350069	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acctgggggatgtgcaggatCttgctgaccgacagcacctc	13	12	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:30350069C>A	uc002kxm.1	-	2	874	c.486G>T	c.(484-486)AAG>AAT	p.K162N		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	162						cytosol|endoplasmic reticulum membrane				ovary(1)	1						TGTGCAGGATCTTGCTGACCG	0.622													1	0	2.73361e-28	0.01441	3.55306e-28	65	74										A	30350069	C	A	30350069	3	1	89	1	0	0	0	0	1	0	0	0	8370	912	32	3	1432	3	KLHL14	18	30350069	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1629962	30350069	47727179	386	26964										
KLHL14	57565	broad.mit.edu	37	chr18	30350105	30350105	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acctcctccaccgtgtccagGgacagggtcacgttggccgt	12	15	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:30350105G>A	uc002kxm.1	-	2	838	c.450C>T	c.(448-450)TCC>TCT	p.S150S		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	150	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						CCGTGTCCAGGGACAGGGTCA	0.642													0	0	0	0.01441	0	70	102										A	30350105	G	A	30350105	2	1	89	1	0	0	0	0	0	0	0	1	8370	1219	43	2		2	KLHL14	18	30350105	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	36	30350105	47727143	387	26965										
CELF4	56853	broad.mit.edu	37	chr18	34852990	34852990	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccagctcacctgaggttgggGtcataggtgcggccgccagg	16	12	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:34852990G>T	uc002lae.2	-	7	1334	c.938C>A	c.(937-939)ACC>AAC	p.T313N	CELF4_uc010dnd.1_Missense_Mutation_p.T311N|CELF4_uc002lag.2_Missense_Mutation_p.T303N|CELF4_uc002laf.2_Missense_Mutation_p.T308N|CELF4_uc002lai.2_Missense_Mutation_p.T298N|CELF4_uc002lah.1_Missense_Mutation_p.T38N|CELF4_uc002laj.1_Missense_Mutation_p.D148E	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	313					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGAGGTTGGGGTCATAGGTGC	0.662													1	0	6.21074e-16	0.011902	7.24152e-16	40	36										T	34852990	G	T	34852990	3	4	89	1	0	0	0	0	1	0	0	0	3218	1261	44	4	546	4	CELF4	18	34852990	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4502885	34852990	43224258	388	26966										
ST8SIA3	51046	broad.mit.edu	37	chr18	55024154	55024154	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttattttaggcaagaaattCttcagcatgtcgatgtaata	7	5	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:55024154C>A	uc002lgn.2	+	3	670	c.313C>A	c.(313-315)CTT>ATT	p.L105I		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	105	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GCAAGAAATTCTTCAGCATGT	0.318													1	0	5.35047e-06	0.01892	5.52982e-06	24	21										A	55024154	C	A	55024154	3	1	89	1	0	0	0	0	1	0	0	0	15232	913	32	3	323	3	ST8SIA3	18	55024154	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	20171164	55024154	23053094	389	26967										
SHD	56961	broad.mit.edu	37	chr19	4280064	4280064	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggtgacaggcgcccaaatgGccaagtggctacgggactac	15	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:4280064G>A	uc002lzw.2	+	1	1467	c.4G>A	c.(4-6)GCC>ACC	p.A2T	SHD_uc010dtu.2_Missense_Mutation_p.A2T	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	2											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCCAAATGGCCAAGTGGCT	0.607													0	0	0	0.004482	0	8	1										A	4280064	G	A	4280064	3	1	89	1	0	0	0	0	1	0	0	0	14275	1203	42	2	6	2	SHD	19	4280064	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		4280064	54848919	390	26968										
LONP1	9361	broad.mit.edu	37	chr19	5693378	5693379	+	Missense_Mutation	DNP	GG	GG	TC													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agggagacttcgccagtcatGgccagattctgccggacagg							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5693378_5693379GG>TC	uc002mcx.2	-	17	2666_2667	c.2633_2634CC>GA	c.(2632-2634)GCC>GGA	p.A878G	LONP1_uc002mcy.2_Missense_Mutation_p.A814G|LONP1_uc010duh.2_Missense_Mutation_p.A619G|LONP1_uc010dui.2_Missense_Mutation_p.A862G|LONP1_uc002mcz.2_Missense_Mutation_p.A682G	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	878					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						CGCCAGTCATGGCCAGATTCTG	0.649													0	0	0	0.004672	0	61	11										TC	5693379	GG	TC	5693378	3	4	89	1	0	0	0	0	1	0	0	0	8892	1335	47	4	253	4	LONP1	19	5693378	Missense_Mutation	DNP	GG	TCGA-FJ-A3ZE-01A-11D-A23M-08	1413314	5693378	53435605	391	26969										
FUT5	2527	broad.mit.edu	37	chr19	5866680	5866680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgctgcagcttccagcaggCcttgcagaaagccagtgccc	11	15	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5866680C>T	uc002mdo.3	-	2	1145	c.1057G>A	c.(1057-1059)GCC>ACC	p.A353T	FUT5_uc010duo.2_Missense_Mutation_p.A353T	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	353	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TTCCAGCAGGCCTTGCAGAAA	0.652													0	0	0	0.010771	0	39	7										T	5866680	C	T	5866680	3	4	89	1	0	0	0	0	1	0	0	0	6107	739	26	2	71	2	FUT5	19	5866680	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	173302	5866680	53262303	392	26970										
C3	718	broad.mit.edu	37	chr19	6696452	6696452	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggtcactgaggtctgcaggtGggatgtcctctttctgcact	13	10	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:6696452G>T	uc002mfm.2	-	23	2950	c.2888C>A	c.(2887-2889)CCA>CAA	p.P963Q		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	963					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GTCTGCAGGTGGGATGTCCTC	0.572													1	0	4.4194e-11	0.013726	4.87628e-11	36	22										T	6696452	G	T	6696452	3	4	89	1	0	0	0	0	1	0	0	0	2204	1348	47	4	2179	4	C3	19	6696452	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	829772	6696452	52432531	393	26971										
VAV1	7409	broad.mit.edu	37	chr19	6828657	6828657	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggctcagtgcgtgaacgagGtcaagcgagacaacgagaca	14	9	2	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:6828657G>T	uc002mfu.1	+	12	1214	c.1117G>T	c.(1117-1119)GTC>TTC	p.V373F	VAV1_uc010xjh.1_Missense_Mutation_p.V341F|VAV1_uc010dva.1_Missense_Mutation_p.V373F|VAV1_uc002mfv.1_Missense_Mutation_p.V318F	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	373	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CGTGAACGAGGTCAAGCGAGA	0.632													1	0	1.36615e-20	0.013726	1.67007e-20	33	520										T	6828657	G	T	6828657	3	4	89	1	0	0	0	0	1	0	0	0	17128	1261	44	4	1163	4	VAV1	19	6828657	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	132205	6828657	52300326	394	26972										
FBN3	84467	broad.mit.edu	37	chr19	8176067	8176067	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctcggcacattcatccctgTctgaggggccccaagattcg	10	14	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:8176067T>C	uc002mjf.2	-	32	4106	c.4085A>G	c.(4084-4086)GAC>GGC	p.D1362G		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1362	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TTCATCCCTGTCTGAGGGGCC	0.637													0	0	0	0.005524	0	35	197										C	8176067	T	C	8176067	3	2	89	1	0	0	0	0	1	0	0	0	5704	1681	58	5	4472	5	FBN3	19	8176067	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1347410	8176067	50952916	395	26973										
MYO1F	4542	broad.mit.edu	37	chr19	8609325	8609325	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtggcgcacacgtcgtccaaGacgctcatgatgcctggggg	15	12	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:8609325G>A	uc002mkg.2	-	14	1494	c.1380C>T	c.(1378-1380)GTC>GTT	p.V460V		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	460	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CGTCGTCCAAGACGCTCATGA	0.657													0	0	0	0.019004	0	35	115										A	8609325	G	A	8609325	2	1	89	1	0	0	0	0	0	0	0	1	10073	929	33	1		1	MYO1F	19	8609325	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	433258	8609325	50519658	396	26974										
MUC16	94025	broad.mit.edu	37	chr19	9001859	9001859	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccagacagggaggctggagtTctcgaggttgccaggtgcat	16	9	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9001859T>C	uc002mkp.2	-	53	40593	c.40389A>G	c.(40387-40389)AGA>AGG	p.R13463R	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.R280R|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGCTGGAGTTCTCGAGGTTG	0.478													0	0	0	0.013537	0	8	39										C	9001859	T	C	9001859	2	2	89	1	0	0	0	0	0	0	0	1	9973	1780	62	5		5	MUC16	19	9001859	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	392534	9001859	50127124	397	26975										
MUC16	94025	broad.mit.edu	37	chr19	9016999	9016999	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actgctgctggtgggcacagGgatccaatgggtgaaacctg	15	9	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9016999G>A	uc002mkp.2	-	27	38200	c.37996C>T	c.(37996-37998)CCT>TCT	p.P12666S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12668	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGGCACAGGGATCCAATGG	0.537													0	0	0	0.005443	0	25	141										A	9016999	G	A	9016999	3	1	89	1	0	0	0	0	1	0	0	0	9973	1232	43	2	5759	2	MUC16	19	9016999	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	15140	9016999	50111984	398	26976										
MUC16	94025	broad.mit.edu	37	chr19	9057120	9057120	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gttcatgtccagaactggtgGttcccacattggtcactgcc	10	12	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9057120G>T	uc002mkp.2	-	3	30530	c.30326C>A	c.(30325-30327)ACC>AAC	p.T10109N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10111	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAACTGGTGGTTCCCACATT	0.488													1	0	2.87052e-16	0.005524	3.36816e-16	38	186										T	9057120	G	T	9057120	3	4	89	1	0	0	0	0	1	0	0	0	9973	1261	44	4	13525	4	MUC16	19	9057120	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	40121	9057120	50071863	399	26977										
MUC16	94025	broad.mit.edu	37	chr19	9058002	9058002	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aactggaggtcctcactttgGccaccgctgtgtttgaggaa	12	10	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9058002G>T	uc002mkp.2	-	3	29648	c.29444C>A	c.(29443-29445)GCC>GAC	p.A9815D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9817	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTCACTTTGGCCACCGCTGT	0.458													1	0	1.08321e-29	0.01441	1.43138e-29	73	138										T	9058002	G	T	9058002	3	4	89	1	0	0	0	0	1	0	0	0	9973	1203	42	4	14407	4	MUC16	19	9058002	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	882	9058002	50070981	400	26978										
MUC16	94025	broad.mit.edu	37	chr19	9068085	9068085	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taagggtaccctgtgatgtcGccctatgaggacctgtttgg	13	9	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9068085G>A	uc002mkp.2	-	3	19565	c.19361C>T	c.(19360-19362)GCG>GTG	p.A6454V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6456	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGATGTCGCCCTATGAGG	0.498													0	0	0	0.01441	0	91	433										A	9068085	G	A	9068085	3	1	89	1	0	0	0	0	1	0	0	0	9973	1087	38	2	24490	2	MUC16	19	9068085	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	10083	9068085	50060898	401	26979										
MUC16	94025	broad.mit.edu	37	chr19	9086125	9086125	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cttcactcttctctgtgtaaGtcatggaagtgtgagtgctg	11	8	4	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9086125G>T	uc002mkp.2	-	1	5894	c.5690C>A	c.(5689-5691)ACT>AAT	p.T1897N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1897	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCTGTGTAAGTCATGGAAGT	0.488													1	0	2.27525e-19	0.021523	2.73919e-19	25	109										T	9086125	G	T	9086125	3	4	89	1	0	0	0	0	1	0	0	0	9973	1029	36	4	38169	4	MUC16	19	9086125	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	18040	9086125	50042858	402	26980										
MUC16	94025	broad.mit.edu	37	chr19	9090068	9090068	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgtgtctgcagatgtttcttCaagccaaatcccttttgtgg	9	9	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9090068C>G	uc002mkp.2	-	1	1951	c.1747G>C	c.(1747-1749)GAA>CAA	p.E583Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	583	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGTTTCTTCAAGCCAAATC	0.532													0	0	0	0.01441	0	104	28										G	9090068	C	G	9090068	3	3	89	1	0	0	0	0	1	0	0	0	9973	835	29	1	42112	1	MUC16	19	9090068	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3943	9090068	50038915	403	26981										
ZNF846	162993	broad.mit.edu	37	chr19	9868990	9868990	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttaccacattctttacagaCatagggcttctctccactgt	5	12	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9868990C>T	uc002mmb.1	-	6	1294	c.763G>A	c.(763-765)GTC>ATC	p.V255I	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Missense_Mutation_p.V126I|ZNF846_uc002mmc.1_Missense_Mutation_p.V126I	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	255	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTTTACAGACATAGGGCTTC	0.393													0	0	0	0.01441	0	47	107										T	9868990	C	T	9868990	3	4	89	1	0	0	0	0	1	0	0	0	18189	478	17	2	842	2	ZNF846	19	9868990	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	778922	9868990	49259993	404	26982										
OLFM2	93145	broad.mit.edu	37	chr19	9968097	9968097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtacaatggtccgcgtgtctGccttgtactgctccaggacc	11	13	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9968097G>A	uc002mmp.2	-	4	450	c.422C>T	c.(421-423)GCA>GTA	p.A141V	OLFM2_uc002mmo.2_Missense_Mutation_p.A63V	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	141	Potential.					extracellular region				large_intestine(1)|skin(1)	2						CCGCGTGTCTGCCTTGTACTG	0.597													0	0	0	0.01441	0	40	146										A	9968097	G	A	9968097	3	1	89	1	0	0	0	0	1	0	0	0	10853	1319	46	2	954	2	OLFM2	19	9968097	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	99107	9968097	49160886	405	26983										
QTRT1	81890	broad.mit.edu	37	chr19	10822952	10822953	+	Frame_Shift_Ins	INS	-	-	C													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcggctgccgaaggacaagINSccccgatatctgatgggggt							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:10822952_10822953insC	uc002mpr.2	+	6	787_788	c.762_763insC	c.(760-765)AAGCCCfs	p.K254fs	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	254_255					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CGAAGGACAAGCCCCGATATCT	0.639																		39	318	---	---								C	10822953	-	C	10822952	7	5	89	1	0	1	1	0	0	0	0	0	12885	962	34	0	784	0	QTRT1	19	10822952	Frame_Shift_Ins	INS	-	TCGA-FJ-A3ZE-01A-11D-A23M-08	854855	10822952	48306031	406	26984										
C19orf52	90580	broad.mit.edu	37	chr19	11040151	11040151	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgcgcgactgcgacatcaacGacgacgaattcctgcacctg	10	14	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11040151G>T	uc002mqd.1	+	2	631	c.556G>T	c.(556-558)GAC>TAC	p.D186Y	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	186											0						CGACATCAACGACGACGAATT	0.672													1	0	3.45148e-53	0.01441	4.87423e-53	100	40										T	11040151	G	T	11040151	3	4	89	1	0	0	0	0	1	0	0	0	1934	1058	37	3	562	3	C19orf52	19	11040151	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	217199	11040151	48088832	407	26985										
SMARCA4	6597	broad.mit.edu	37	chr19	11143966	11143966	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	actggcacctcttcccccagGacctgcaagcgcaggaccga	10	17	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11143966G>C	uc002mqf.3	+	26	3831	c.3547G>C	c.(3547-3549)GAC>CAC	p.D1183H	SMARCA4_uc010dxp.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxo.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxq.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxr.2_Missense_Mutation_p.D1183H|SMARCA4_uc002mqj.3_Missense_Mutation_p.D1183H|SMARCA4_uc010dxs.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxt.1_Missense_Mutation_p.D403H|SMARCA4_uc002mqh.3_Missense_Mutation_p.D306H|SMARCA4_uc002mqi.1_Missense_Mutation_p.D386H	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1183	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTTCCCCCAGGACCTGCAAGC	0.627			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.01441	0	107	48										C	11143966	G	C	11143966	3	2	89	1	0	0	0	0	1	0	0	0	14770	1188	41	1	3645	1	SMARCA4	19	11143966	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	103815	11143966	47985017	408	26986										
ZNF653	115950	broad.mit.edu	37	chr19	11609127	11609127	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttacttttcttccgctttggCtttttggggacctgctccca	8	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11609127C>T	uc002mrz.1	-	2	380	c.327G>A	c.(325-327)AAG>AAA	p.K109K		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	109	Nuclear localization signal (Potential).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCGCTTTGGCTTTTTGGGGA	0.498													0	0	0	0.01441	0	138	514										T	11609127	C	T	11609127	2	4	89	1	0	0	0	0	0	0	0	1	18063	796	28	2		2	ZNF653	19	11609127	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	465161	11609127	47519856	409	26987										
ZNF878	729747	broad.mit.edu	37	chr19	12167103	12167103	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctctgaaaggtacaaccccaGataggacagaacccccgagc	9	14	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:12167103G>C	uc002mta.1	-	1	25	c.25C>G	c.(25-27)CTG>GTG	p.L9V		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	Error:Variant_position_missing_in_C9JN71_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TACAACCCCAGATAGGACAGA	0.562													0	0	0	0.014758	0	4	4										C	12167103	G	C	12167103	3	2	89	1	0	0	0	0	1	0	0	0	18193	933	33	1	1731	1	ZNF878	19	12167103	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	557976	12167103	46961880	410	26988										
NANOS3	342977	broad.mit.edu	37	chr19	13988397	13988397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catcctgcgggactacgtgtGtccccagtgcggcgccacac	12	16	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:13988397G>A	uc002mxj.3	+	1	448	c.335G>A	c.(334-336)TGT>TAT	p.C112Y		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	93	C2HC 2.|Nanos-type.				anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GACTACGTGTGTCCCCAGTGC	0.647													0	0	0	0.008361	0	30	27										A	13988397	G	A	13988397	3	1	89	1	0	0	0	0	1	0	0	0	10153	1377	48	2	337	2	NANOS3	19	13988397	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1821294	13988397	45140586	411	26989										
CCDC105	126402	broad.mit.edu	37	chr19	15121757	15121757	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	attctgaccgatcgctgcggGcaggaggcggtgaccatgtg	16	10	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:15121757G>A	uc002nae.2	+	1	219	c.120G>A	c.(118-120)GGG>GGA	p.G40G	SLC1A6_uc010xod.1_5'Flank	NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	40					microtubule cytoskeleton organization	microtubule				ovary(1)	1						ATCGCTGCGGGCAGGAGGCGG	0.711													0	0	0	0.001984	0	5	12										A	15121757	G	A	15121757	2	1	89	1	0	0	0	0	0	0	0	1	2740	1190	42	2		2	CCDC105	19	15121757	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1133360	15121757	44007226	412	26990										
AKAP8L	26993	broad.mit.edu	37	chr19	15491178	15491178	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgcgccccctcgtccagggCaccgccctcagcctcctcct	8	23	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:15491178C>G	uc002naw.1	-	14	1795	c.1696G>C	c.(1696-1698)GCC>CCC	p.A566P	AKAP8_uc002nav.2_5'Flank|AKAP8_uc010xog.1_5'Flank|AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.A505P	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	566				EEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPE PA -> RRRRSRRRLRAVPWTRGRRAKRQGFRRAQRACRRS LPCPQSQP (in Ref. 3; AAF86048).		cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						TCGTCCAGGGCACCGCCCTCA	0.741													0	0	0	0.001984	0	7	7										G	15491178	C	G	15491178	3	3	89	1	0	0	0	0	1	0	0	0	458	710	25	4	248	4	AKAP8L	19	15491178	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	369421	15491178	43637805	413	26991										
PIK3R2	5296	broad.mit.edu	37	chr19	18273235	18273235	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagggaggaggtgaacgagaAactccgggacactcccgatg	15	10	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:18273235A>G	uc002nia.1	+	9	1540	c.1028A>G	c.(1027-1029)AAA>AGA	p.K343R	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	343	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						GTGAACGAGAAACTCCGGGAC	0.627													0	0	0	0.007413	0	17	38										G	18273235	A	G	18273235	3	3	89	1	0	0	0	0	1	0	0	0	11919	14	1	5	1058	5	PIK3R2	19	18273235	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	2782057	18273235	40855748	414	26992										
CILP2	148113	broad.mit.edu	37	chr19	19650559	19650559	+	Frame_Shift_Del	DEL	C	C	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggtccgtgtacaccggccagCcctcaccagccctggaggac							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:19650559delC	uc002nmv.3	+	2	221	c.136delC	c.(136-138)CCCfs	p.P46fs	CILP2_uc002nmw.3_Frame_Shift_Del_p.P46fs	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	46						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CACCGGCCAGCCCTCACCAGC	0.667																		72	104	---	---								-	19650559	C	-	19650559	7	5	89	1	0	1	0	1	0	0	0	0	3430	739	26	0	142	0	CILP2	19	19650559	Frame_Shift_Del	DEL	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1377324	19650559	39478424	415	26993										
ZNF682	91120	broad.mit.edu	37	chr19	20117916	20117916	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgacaaacattggttaagtCcattataaatttctttttga	5	5	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:20117916C>A	uc002noq.2	-	4	518	c.395G>T	c.(394-396)GGA>GTA	p.G132V	ZNF682_uc002noo.2_Missense_Mutation_p.G100V|ZNF682_uc002nop.2_Missense_Mutation_p.G100V|ZNF682_uc010eck.2_Missense_Mutation_p.G56V	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TTGGTTAAGTCCATTATAAAT	0.323													1	0	2.4375e-19	0.007291	2.92816e-19	28	43										A	20117916	C	A	20117916	3	1	89	1	0	0	0	0	1	0	0	0	18086	855	30	3	1105	3	ZNF682	19	20117916	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	467357	20117916	39011067	416	26994										
KIAA0355	9710	broad.mit.edu	37	chr19	34832392	34832392	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgtgattttggcaaccaggCtgacctgccttctggaaatg	11	10	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:34832392C>A	uc002nvd.3	+	10	2412	c.1553C>A	c.(1552-1554)GCT>GAT	p.A518D		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	518										ovary(1)	1	Esophageal squamous(110;0.162)					GGCAACCAGGCTGACCTGCCT	0.428													1	0	1.27862e-28	0.01441	1.66973e-28	55	57										A	34832392	C	A	34832392	3	1	89	1	0	0	0	0	1	0	0	0	8170	797	28	4	1587	4	KIAA0355	19	34832392	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	14714476	34832392	24296591	417	26995										
PRODH2	58510	broad.mit.edu	37	chr19	36303753	36303753	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagggaaggttctctggaggCagcaagttcaccaactgccc	12	12	2	0	rs142806923	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:36303753C>G	uc002obx.1	-	2	201	c.183G>C	c.(181-183)CTG>CTC	p.L61L		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	61					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCTGGAGGCAGCAAGTTCA	0.587													0	0	0	0.006122	0	19	20										G	36303753	C	G	36303753	2	3	89	1	0	0	0	0	0	0	0	1	12549	697	25	4		4	PRODH2	19	36303753	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1471361	36303753	22825230	418	26996										
APLP1	333	broad.mit.edu	37	chr19	36365745	36365745	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgtggccgccgtggatcccGagaaggcacagcagatgcgc	15	12	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:36365745G>A	uc002oce.2	+	10	1456	c.1318G>A	c.(1318-1320)GAG>AAG	p.E440K	APLP1_uc010xsz.1_Missense_Mutation_p.E401K|APLP1_uc002ocf.2_Missense_Mutation_p.E440K|APLP1_uc002ocg.2_Missense_Mutation_p.E343K|APLP1_uc010xta.1_Missense_Mutation_p.E434K	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	440	Extracellular (Potential).|Heparin-binding (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTGGATCCCGAGAAGGCACA	0.642													0	0	0	0.005443	0	25	26										A	36365745	G	A	36365745	3	1	89	1	0	0	0	0	1	0	0	0	778	1059	37	1	1356	1	APLP1	19	36365745	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	61992	36365745	22763238	419	26997										
FAM98C	147965	broad.mit.edu	37	chr19	38896273	38896273	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccactggagtgaccgggcaGaggtgtggtgggcaggggac	20	8	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:38896273G>C	uc002oin.1	+	6	767	c.748G>C	c.(748-750)GAG>CAG	p.E250Q	FAM98C_uc002oio.1_Missense_Mutation_p.E224Q|FAM98C_uc010xtz.1_Intron	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	250										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGACCGGGCAGAGGTGTGGTG	0.607													0	0	0	0.004656	0	23	36										C	38896273	G	C	38896273	3	2	89	1	0	0	0	0	1	0	0	0	5658	943	33	1	770	1	FAM98C	19	38896273	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2530528	38896273	20232710	420	26998										
LRFN1	57622	broad.mit.edu	37	chr19	39804639	39804639	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgcgtattccgggcacaggCctctgggctggccagcggat	15	12	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:39804639C>A	uc002okw.2	-	1	1338	c.1338G>T	c.(1336-1338)AGG>AGT	p.R446S		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	446	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGGGCACAGGCCTCTGGGCTG	0.647													1	0	2.32078e-09	0.003163	2.49619e-09	16	39										A	39804639	C	A	39804639	3	1	89	1	0	0	0	0	1	0	0	0	8937	738	26	4	985	4	LRFN1	19	39804639	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	908366	39804639	19324344	421	26999										
CEACAM4	1089	broad.mit.edu	37	chr19	42132180	42132180	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcaatgagagggctcccttcTgccgttttccccttgtgcca	10	14	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:42132180T>A	uc002orh.1	-	2	330	c.219A>T	c.(217-219)GCA>GCT	p.A73A	CEACAM4_uc010xwd.1_Silent_p.A73A	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	73	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction					0						GGCTCCCTTCTGCCGTTTTCC	0.493													0	0	0	0.01441	0	87	54										A	42132180	T	A	42132180	2	1	89	1	0	0	0	0	0	0	0	1	3194	1567	55	5		5	CEACAM4	19	42132180	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	2327541	42132180	16996803	422	27000										
ZNF225	7768	broad.mit.edu	37	chr19	44636769	44636769	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttgtgcacagttcatgccttAaagaccaacaaagagaccaa	7	10	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:44636769A>T	uc002oyj.1	+	5	2245	c.2002A>T	c.(2002-2004)AAA>TAA	p.K668*	ZNF225_uc010eje.1_Nonsense_Mutation_p.K585*|ZNF225_uc010ejf.1_Nonsense_Mutation_p.K668*	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	668	C2H2-type 18; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TTCATGCCTTAAAGACCAACA	0.443													0	0	0	0.016522	0	23	9										T	44636769	A	T	44636769	4	4	89	1	0	0	0	0	0	1	0	0	17776	363	13	5	2016	5	ZNF225	19	44636769	Nonsense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	2504589	44636769	14492214	423	27001										
ERCC2	2068	broad.mit.edu	37	chr19	45860917	45860917	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aggatggggttggcaatggtCggggttctgtcgtcaaaggg	19	5	2	0	rs148469762	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:45860917C>G	uc002pbj.2	-	13	1325	c.1278G>C	c.(1276-1278)CCG>CCC	p.P426P	ERCC2_uc002pbh.2_5'UTR|ERCC2_uc002pbi.2_Silent_p.P119P|ERCC2_uc010ejz.2_Silent_p.P348P|ERCC2_uc002pbk.2_Silent_p.P402P	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	426					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGCAATGGTCGGGGTTCTGT	0.642			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.013537	0	12	52										G	45860917	C	G	45860917	2	3	89	1	0	0	0	0	0	0	0	1	5213	871	31	1		1	ERCC2	19	45860917	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1224148	45860917	13268066	424	27002										
TPRX1	284355	broad.mit.edu	37	chr19	48305975	48305975	+	Frame_Shift_Del	DEL	G	G	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgggattggggcagggatcGggccagggcctggactcagg							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48305975delG	uc002php.1	-	2	364	c.293delC	c.(292-294)CCGfs	p.P98fs		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	98	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		ggcagggATCGGGCCAGGGCC	0.368																		4	4	---	---								-	48305975	G	-	48305975	7	5	89	1	0	1	0	1	0	0	0	0	16419	1116	39	0	946	0	TPRX1	19	48305975	Frame_Shift_Del	DEL	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2445058	48305975	10823008	425	27003										
TMEM143	55260	broad.mit.edu	37	chr19	48845927	48845927	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cagcatgaggttgagcagggCgcgctgcagggtgggcgtgc	20	9	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48845927C>G	uc002pix.1	-	6	844	c.835G>C	c.(835-837)GCC>CCC	p.A279P	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.A244P|TMEM143_uc010xzn.1_Missense_Mutation_p.A214P|TMEM143_uc010elw.1_Missense_Mutation_p.A179P|TMEM143_uc010xzo.1_Missense_Mutation_p.A69P	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	279						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		TTGAGCAGGGCGCGCTGCAGG	0.642													0	0	0	0.005524	0	35	24										G	48845927	C	G	48845927	3	3	89	1	0	0	0	0	1	0	0	0	16054	768	27	4	556	4	TMEM143	19	48845927	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	539952	48845927	10283056	426	27004										
TMEM143	55260	broad.mit.edu	37	chr19	48846055	48846055	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gggctgccaggaccacccgcTtaaagtatctcctgagggac	12	13	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48846055T>G	uc002pix.1	-	6	716	c.707A>C	c.(706-708)AAG>ACG	p.K236T	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.K201T|TMEM143_uc010xzn.1_Missense_Mutation_p.K171T|TMEM143_uc010elw.1_Missense_Mutation_p.K136T|TMEM143_uc010xzo.1_Missense_Mutation_p.K26T|TMEM143_uc010xzp.1_3'UTR|TMEM143_uc010xzq.1_3'UTR	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	236						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GACCACCCGCTTAAAGTATCT	0.627													0	0	0	0.009535	0	26	16										G	48846055	T	G	48846055	3	3	89	1	0	0	0	0	1	0	0	0	16054	1609	56	5	684	5	TMEM143	19	48846055	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	128	48846055	10282928	427	27005										
KCNJ14	3770	broad.mit.edu	37	chr19	48965180	48965180	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	acgtgcgtttcgtaaacctgGgtggccagggcgcgcgctac	15	12	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48965180G>A	uc002pje.1	+	2	604	c.199G>A	c.(199-201)GGT>AGT	p.G67S	KCNJ14_uc002pjf.1_Missense_Mutation_p.G67S	NM_013348	NP_037480	Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel J14	67	Cytoplasmic (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		CGTAAACCTGGGTGGCCAGGG	0.677													0	0	0	0.00499	0	17	11										A	48965180	G	A	48965180	3	1	89	1	0	0	0	0	1	0	0	0	8048	1232	43	2	201	2	KCNJ14	19	48965180	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	119125	48965180	10163803	428	27006										
TULP2	7288	broad.mit.edu	37	chr19	49385331	49385331	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gaagttcttcaccgaagcccGagtgactcgaccatggaaat	10	11	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49385331G>A	uc002pkz.2	-	12	1556	c.1405C>T	c.(1405-1407)CGG>TGG	p.R469W		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	469					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ACCGAAGCCCGAGTGACTCGA	0.547													0	0	0	0.006122	0	16	81										A	49385331	G	A	49385331	3	1	89	1	0	0	0	0	1	0	0	0	16771	1057	37	1	165	1	TULP2	19	49385331	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	420151	49385331	9743652	429	27007										
PPFIA3	8541	broad.mit.edu	37	chr19	49649253	49649253	+	Frame_Shift_Del	DEL	G	G	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atggagtcccttacggccacGaccaagcccgtgagtgcccc							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49649253delG	uc002pmr.2	+	22	3131	c.2799delG	c.(2797-2799)ACGfs	p.T933fs	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Frame_Shift_Del_p.T801fs|PPFIA3_uc002pmt.2_Frame_Shift_Del_p.T81fs|PPFIA3_uc002pmu.1_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	933						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TTACGGCCACGACCAAGCCCG	0.642											OREG0025618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						50	54	---	---								-	49649253	G	-	49649253	7	5	89	1	0	1	0	1	0	0	0	0	12311	1045	37	0	2881	0	PPFIA3	19	49649253	Frame_Shift_Del	DEL	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	263922	49649253	9479730	430	27008										
TEAD2	8463	broad.mit.edu	37	chr19	49863219	49863219	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cacaccccctctgcatccggGcccccgtcacccccagcccc	6	26	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49863219G>T	uc002pnj.2	-	2	205	c.114C>A	c.(112-114)GGC>GGA	p.G38G	TEAD2_uc002png.2_Silent_p.G38G|TEAD2_uc002pnh.2_Silent_p.G38G|TEAD2_uc002pni.2_Silent_p.G38G|TEAD2_uc010yao.1_Intron|TEAD2_uc010emw.2_Silent_p.G38G	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	38					hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		CTGCATCCGGGCCCCCGTCAC	0.677													1	0	1.1397e-45	0.01441	1.57347e-45	74	32										T	49863219	G	T	49863219	2	4	89	1	0	0	0	0	0	0	0	1	15736	1190	42	4		4	TEAD2	19	49863219	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	213966	49863219	9265764	431	27009										
C19orf41	126123	broad.mit.edu	37	chr19	50657922	50657922	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atgaggatgcccaacagcgcCtggttcctcgggtatttgct	12	11	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:50657922C>T	uc002prp.1	-	6	645	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	186	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CCAACAGCGCCTGGTTCCTCG	0.622													0	0	0	0.016522	0	21	78										T	50657922	C	T	50657922	2	4	89	1	0	0	0	0	0	0	0	1	1924	680	24	2		2	C19orf41	19	50657922	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	794703	50657922	8471061	432	27010										
KLK15	55554	broad.mit.edu	37	chr19	51329189	51329189	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gatgcccccacagaccagggGtcccccagagtcaccctgtg	11	17	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:51329189G>A	uc002ptl.2	-	5	665	c.634C>T	c.(634-636)CCC>TCC	p.P212S	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Missense_Mutation_p.P127S|KLK15_uc002ptn.2_3'UTR|KLK15_uc002pto.2_Missense_Mutation_p.P211S|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_3'UTR|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	212	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CAGACCAGGGGTCCCCCAGAG	0.542													0	0	0	0.017118	0	33	19										A	51329189	G	A	51329189	3	1	89	1	0	0	0	0	1	0	0	0	8403	1261	44	2	140	2	KLK15	19	51329189	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	671267	51329189	7799794	433	27011										
UBE2S	27338	broad.mit.edu	37	chr19	55915730	55915730	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gacgcagatctcgccattggCgcccacgttcgggtggaaga	14	12	1	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:55915730C>A	uc002qkx.1	-	3	636	c.268G>T	c.(268-270)GCC>TCC	p.A90S		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	90					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCGCCATTGGCGCCCACGTTC	0.617													1	0	2.37825e-27	0.010771	3.05539e-27	32	22										A	55915730	C	A	55915730	3	1	89	1	0	0	0	0	1	0	0	0	16869	768	27	4	408	4	UBE2S	19	55915730	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4586541	55915730	3213253	434	27012										
ZNF773	374928	broad.mit.edu	37	chr19	58018245	58018245	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atcctttagccgtaatgctgAcctcattcaacaccagagag	7	12	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:58018245A>G	uc002qox.2	+	4	922	c.782A>G	c.(781-783)GAC>GGC	p.D261G	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Missense_Mutation_p.D260G|ZNF773_uc002qoz.2_Intron	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	261	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		CGTAATGCTGACCTCATTCAA	0.418													0	0	0	0.01892	0	24	71										G	58018245	A	G	58018245	3	3	89	1	0	0	0	0	1	0	0	0	18143	275	10	5	796	5	ZNF773	19	58018245	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	2102515	58018245	1110738	435	27013										
TRIB3	57761	broad.mit.edu	37	chr20	377174	377174	+	Frame_Shift_Del	DEL	C	C	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gccagctgaacggctcacagCcacaggcatcctcctgcacc							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:377174delC	uc002wdm.2	+	4	1423	c.917delC	c.(916-918)GCCfs	p.A306fs	TRIB3_uc002wdn.2_Frame_Shift_Del_p.A333fs	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	306	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CGGCTCACAGCCACAGGCATC	0.687																		45	197	---	---								-	377174	C	-	377174	7	5	89	1	0	1	0	1	0	0	0	0	16481	739	26	0	927	0	TRIB3	20	377174	Frame_Shift_Del	DEL	C	TCGA-FJ-A3ZE-01A-11D-A23M-08		377174	62648346	436	27014										
ANGPT4	51378	broad.mit.edu	37	chr20	869075	869075	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catccattcttgatgtctggTtcaggagctgccccagcaag	10	12	3	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:869075T>A	uc002wei.2	-	3	576	c.473A>T	c.(472-474)AAC>ATC	p.N158I	ANGPT4_uc010zpn.1_Missense_Mutation_p.N152I	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	158	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						TGATGTCTGGTTCAGGAGCTG	0.602													0	0	0	0.007413	0	16	100										A	869075	T	A	869075	3	1	89	1	0	0	0	0	1	0	0	0	612	1725	60	5	1066	5	ANGPT4	20	869075	Missense_Mutation	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	491901	869075	62156445	437	27015										
TMC2	117532	broad.mit.edu	37	chr20	2596782	2596782	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctccctccctccctctctaGccttcatatgctgagtttga	6	16	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:2596782G>T	uc002wgf.1	+	15	1888	c.1873_splice	c.e15-1	p.P625_splice	TMC2_uc002wgg.1_Splice_Site_p.P609_splice	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2							integral to membrane				ovary(3)	3						tccctctctAGCCTTCATATG	0.368													1	0	2.70662e-09	0.009535	2.90556e-09	32	43										T	2596782	G	T	2596782	5	4	89	1	0	0	0	0	0	0	1	0	15982	985	34	4	1930	4	TMC2	20	2596782	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1727707	2596782	60428738	438	27016										
MAVS	57506	broad.mit.edu	37	chr20	3845324	3845324	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	aatccagcaccatccaaattGcccatcaactcaacccgtgc	4	17	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:3845324G>T	uc002wjw.3	+	6	1216	c.1047G>T	c.(1045-1047)TTG>TTT	p.L349F	MAVS_uc002wjx.3_Missense_Mutation_p.L208F|MAVS_uc002wjy.3_Missense_Mutation_p.L47F	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	349	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CATCCAAATTGCCCATCAACT	0.567													1	0	1.4374e-25	0.01441	1.82972e-25	54	156										T	3845324	G	T	3845324	3	4	89	1	0	0	0	0	1	0	0	0	9338	1310	46	4	1065	4	MAVS	20	3845324	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1248542	3845324	59180196	439	27017										
TMX4	56255	broad.mit.edu	37	chr20	7980425	7980425	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agtcagaggctcgactgattGccatttcttctctaagatat	8	9	3	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:7980425G>C	uc002wmx.1	-	4	554	c.421C>G	c.(421-423)CAA>GAA	p.Q141E		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	141					cell redox homeostasis|electron transport chain|transport	integral to membrane					0						TCGACTGATTGCCATTTCTTC	0.403													0	0	0	0.006122	0	18	54										C	7980425	G	C	7980425	3	2	89	1	0	0	0	0	1	0	0	0	16266	1328	46	4	648	4	TMX4	20	7980425	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	4135101	7980425	55045095	440	27018										
SPTLC3	55304	broad.mit.edu	37	chr20	13134777	13134777	+	Frame_Shift_Del	DEL	T	T	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctgcttctttatatgcctggTaaagtagcgtaagtatccaa							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:13134777delT	uc002wod.1	+	10	1696	c.1407delT	c.(1405-1407)GGTfs	p.G469fs		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	469					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	ATATGCCTGGTAAAGTAGCGT	0.408																		32	87	---	---								-	13134777	T	-	13134777	7	5	89	1	0	1	0	1	0	0	0	0	15124	1625	57	0	1445	0	SPTLC3	20	13134777	Frame_Shift_Del	DEL	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	5154352	13134777	49890743	441	27019										
FLRT3	23767	broad.mit.edu	37	chr20	14307612	14307612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatgcgattatcatccaagcGtagttcttctatagtcctgg	8	9	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:14307612G>A	uc002wov.1	-	3	1008	c.541C>T	c.(541-543)CGC>TGC	p.R181C	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R181C	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	181	Extracellular (Potential).|LRR 6.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCATCCAAGCGTAGTTCTTCT	0.458													0	0	0	0.01892	0	23	145										A	14307612	G	A	14307612	3	1	89	1	0	0	0	0	1	0	0	0	5940	1145	40	2	1412	2	FLRT3	20	14307612	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	1172835	14307612	48717908	442	27020										
RRBP1	6238	broad.mit.edu	37	chr20	17639309	17639309	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cttgctttggtgcctctgggCtctgggccacatctgtattt	11	11	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:17639309C>A	uc002wpv.1	-	4	908	c.554G>T	c.(553-555)AGC>ATC	p.S185I	RRBP1_uc002wpu.2_5'UTR|RRBP1_uc002wpw.1_Missense_Mutation_p.S185I|RRBP1_uc010gcl.1_Intron	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	615	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						TGCCTCTGGGCTCTGGGCCAC	0.493													1	0	1.38909e-20	0.01441	1.69439e-20	51	98										A	17639309	C	A	17639309	3	1	89	1	0	0	0	0	1	0	0	0	13678	797	28	4	2471	4	RRBP1	20	17639309	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3331697	17639309	45386211	443	27021										
HCK	3055	broad.mit.edu	37	chr20	30672193	30672193	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgaccagggactctgttccaGaggggaacgacgggctctgc	15	11	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:30672193G>C	uc002wxh.2	+	8	854	c.683_splice	c.e8-1	p.K228_splice	HCK_uc010gdy.2_Splice_Site_p.K207_splice|HCK_uc002wxi.2_Splice_Site_p.K206_splice	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK						interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTCTGTTCCAGAGGGGAACGA	0.597													0	0	0	0.010729	0	12	26										C	30672193	G	C	30672193	5	2	89	1	0	0	0	0	0	0	1	0	6994	956	33	1	718	1	HCK	20	30672193	Splice_Site	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	13032884	30672193	32353327	444	27022										
HCK	3055	broad.mit.edu	37	chr20	30672279	30672279	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgggagaaagatgcctgggaGatccctcgggaatccctcaa	13	10	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:30672279G>A	uc002wxh.2	+	8	939	c.768G>A	c.(766-768)GAG>GAA	p.E256E	HCK_uc010gdy.2_Silent_p.E235E|HCK_uc002wxi.2_Silent_p.E234E	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	256					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATGCCTGGGAGATCCCTCGGG	0.602													0	0	0	0.009535	0	30	84										A	30672279	G	A	30672279	2	1	89	1	0	0	0	0	0	0	0	1	6994	933	33	1		1	HCK	20	30672279	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	86	30672279	32353241	445	27023										
CEP250	11190	broad.mit.edu	37	chr20	34085680	34085680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cctccttgtgggcccaggaaGccaaggcagcccaactacag	11	15	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:34085680G>A	uc002xcm.2	+	27	4110	c.3439G>A	c.(3439-3441)GCC>ACC	p.A1147T	CEP250_uc010zve.1_Missense_Mutation_p.A515T	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1147	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGCCCAGGAAGCCAAGGCAGC	0.662													0	0	0	0.016723	0	14	10										A	34085680	G	A	34085680	3	1	89	1	0	0	0	0	1	0	0	0	3252	971	34	2	3529	2	CEP250	20	34085680	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	3413401	34085680	28939840	446	27024										
CHD6	84181	broad.mit.edu	37	chr20	40033665	40033665	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcacatcatggctactcggCttgtcttccgcagtcttttc	7	13	4	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:40033665C>G	uc002xka.1	-	37	7894	c.7716G>C	c.(7714-7716)AAG>AAC	p.K2572N	CHD6_uc002xjz.1_Missense_Mutation_p.K109N	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2572					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GGCTACTCGGCTTGTCTTCCG	0.502													0	0	0	0.01441	0	75	189										G	40033665	C	G	40033665	3	3	89	1	0	0	0	0	1	0	0	0	3329	796	28	4	435	4	CHD6	20	40033665	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5947985	40033665	22991855	447	27025										
MATN4	8785	broad.mit.edu	37	chr20	43933116	43933116	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gcacgcgctcctctggcggtCgcgcgccctcggccacactg	13	19	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:43933116C>T	uc002xnn.2	-	3	582	c.395G>A	c.(394-396)CGA>CAA	p.R132Q	MATN4_uc002xno.2_Missense_Mutation_p.R132Q|MATN4_uc002xnp.2_Missense_Mutation_p.R132Q|MATN4_uc010zwr.1_Missense_Mutation_p.R80Q|MATN4_uc002xnr.1_Missense_Mutation_p.R132Q|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	132	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CTCTGGCGGTCGCGCGCCCTC	0.731													0	0	0	0.001168	0	6	19										T	43933116	C	T	43933116	3	4	89	1	0	0	0	0	1	0	0	0	9336	884	31	1	1382	1	MATN4	20	43933116	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	3899451	43933116	19092404	448	27026										
ZMYND8	23613	broad.mit.edu	37	chr20	45912357	45912357	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tctcgtttttggcaagcagcTagataacattctggacatac	8	9	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:45912357T>C	uc002xta.1	-	9	1034	c.780A>G	c.(778-780)CTA>CTG	p.L260L	ZMYND8_uc010ghr.1_Silent_p.L235L|ZMYND8_uc002xst.1_Silent_p.L235L|ZMYND8_uc002xsu.1_Silent_p.L260L|ZMYND8_uc002xsv.1_Silent_p.L235L|ZMYND8_uc002xsw.1_Silent_p.L12L|ZMYND8_uc002xsx.1_Silent_p.L12L|ZMYND8_uc002xsy.1_Silent_p.L235L|ZMYND8_uc002xsz.1_Silent_p.L197L|ZMYND8_uc010zxy.1_Silent_p.L287L|ZMYND8_uc002xtb.1_Silent_p.L280L|ZMYND8_uc002xss.2_Silent_p.L260L|ZMYND8_uc010zxz.1_Silent_p.L255L|ZMYND8_uc002xtc.1_Silent_p.L280L|ZMYND8_uc002xtd.1_Silent_p.L255L|ZMYND8_uc002xte.1_Silent_p.L260L|ZMYND8_uc010zya.1_Silent_p.L260L|ZMYND8_uc002xtf.1_Silent_p.L280L|ZMYND8_uc002xtg.2_Silent_p.L254L|ZMYND8_uc010ghs.1_Silent_p.L254L	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	260							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGCAAGCAGCTAGATAACATT	0.393													0	0	0	0.016723	0	14	75										C	45912357	T	C	45912357	2	2	89	1	0	0	0	0	0	0	0	1	17708	1509	53	5		5	ZMYND8	20	45912357	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	1979241	45912357	17113163	449	27027										
ZMYND8	23613	broad.mit.edu	37	chr20	45927519	45927519	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cctctggttccgatgtcagtCtcagacacttagcgtgataa	9	11	3	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:45927519C>A	uc002xta.1	-	4	601	c.347G>T	c.(346-348)AGA>ATA	p.R116I	ZMYND8_uc010ghr.1_Missense_Mutation_p.R91I|ZMYND8_uc002xst.1_Missense_Mutation_p.R91I|ZMYND8_uc002xsu.1_Missense_Mutation_p.R116I|ZMYND8_uc002xsv.1_Missense_Mutation_p.R91I|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.R91I|ZMYND8_uc002xsz.1_Missense_Mutation_p.R91I|ZMYND8_uc010zxy.1_Missense_Mutation_p.R143I|ZMYND8_uc002xtb.1_Missense_Mutation_p.R136I|ZMYND8_uc002xss.2_Missense_Mutation_p.R116I|ZMYND8_uc010zxz.1_Missense_Mutation_p.R111I|ZMYND8_uc002xtc.1_Missense_Mutation_p.R136I|ZMYND8_uc002xtd.1_Missense_Mutation_p.R111I|ZMYND8_uc002xte.1_Missense_Mutation_p.R116I|ZMYND8_uc010zya.1_Missense_Mutation_p.R116I|ZMYND8_uc002xtf.1_Missense_Mutation_p.R136I|ZMYND8_uc002xtg.2_Missense_Mutation_p.R110I|ZMYND8_uc010ghs.1_Missense_Mutation_p.R110I|ZMYND8_uc002xth.2_Missense_Mutation_p.R136I	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	116	PHD-type.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CGATGTCAGTCTCAGACACTT	0.502													1	0	9.17885e-22	0.015359	1.13711e-21	36	24										A	45927519	C	A	45927519	3	1	89	1	0	0	0	0	1	0	0	0	17708	913	32	3	3239	3	ZMYND8	20	45927519	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	15162	45927519	17098001	450	27028										
ZNFX1	57169	broad.mit.edu	37	chr20	47864087	47864088	+	In_Frame_Ins	INS	-	-	GGC													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcttcctctgagatgcccaINSggccagagcagggaagggtg							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:47864087_47864088insGGC	uc002xui.2	-	14	5720_5721	c.5473_5474insGCC	c.(5473-5475)CTG>CGCCTG	p.1824_1825insR		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1824_1825							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGAGATGCCCAGGCCAGAGCAG	0.495																		42	147	---	---								GGC	47864088	-	GGC	47864087	7	5	89	1	0	1	1	0	0	0	0	0	18202	188	7	0	286	0	ZNFX1	20	47864087	In_Frame_Ins	INS	-	TCGA-FJ-A3ZE-01A-11D-A23M-08	1936568	47864087	15161433	451	27029										
NFATC2	4773	broad.mit.edu	37	chr20	50048713	50048713	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccgtttttggcggctctttgGctcgtggcattctgctgctg	13	11	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:50048713G>A	uc002xwd.2	-	9	2833	c.2613C>T	c.(2611-2613)AGC>AGT	p.S871S	NFATC2_uc002xwc.2_Silent_p.S871S|NFATC2_uc010zyv.1_Silent_p.S652S|NFATC2_uc010zyw.1_Silent_p.S652S|NFATC2_uc010zyx.1_Silent_p.S851S|NFATC2_uc010zyy.1_Silent_p.S652S|NFATC2_uc010zyz.1_Silent_p.S652S|NFATC2_uc002xwe.2_Silent_p.S851S	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	871					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGGCTCTTTGGCTCGTGGCAT	0.592													0	0	0	0.01441	0	51	117										A	50048713	G	A	50048713	2	1	89	1	0	0	0	0	0	0	0	1	10362	1194	42	2		2	NFATC2	20	50048713	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	2184626	50048713	12976807	452	27030										
GATA5	140628	broad.mit.edu	37	chr20	61050567	61050567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggctcgcggccagcgccaggCtctggtacatcctcccaggc	13	17	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:61050567C>T	uc002ycx.1	-	2	73	c.11G>A	c.(10-12)AGC>AAC	p.S4N		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	4					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CAGCGCCAGGCTCTGGTACAT	0.716													0	0	0	0.00308	0	5	13										T	61050567	C	T	61050567	3	4	89	1	0	0	0	0	1	0	0	0	6257	797	28	2	1206	2	GATA5	20	61050567	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	11001854	61050567	1974953	453	27031										
PTK6	5753	broad.mit.edu	37	chr20	62162261	62162261	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccagcagctccgaaacgggCaggactttctcatcagagtc	10	13	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62162261C>T	uc002yfg.2	-	6	892	c.852G>A	c.(850-852)CTG>CTA	p.L284L	PTK6_uc011aay.1_Silent_p.L183L|PTK6_uc011aaz.1_Silent_p.L46L	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	284	Protein kinase.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CCGAAACGGGCAGGACTTTCT	0.622													0	0	0	0.010818	0	32	15										T	62162261	C	T	62162261	2	4	89	1	0	0	0	0	0	0	0	1	12764	697	25	2		2	PTK6	20	62162261	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1111694	62162261	863259	454	27032										
ARFRP1	10139	broad.mit.edu	37	chr20	62337724	62337724	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cttaccttgtcccacaaagaCtgcagctcttcctgccctcc	5	18	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62337724C>T	uc002yga.2	-	3	816	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q	ARFRP1_uc002ygc.2_Silent_p.Q83Q|ARFRP1_uc002ygh.3_Silent_p.Q83Q|ARFRP1_uc011abf.1_Silent_p.Q83Q|ARFRP1_uc011abg.1_Silent_p.Q83Q|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Silent_p.Q83Q|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	83					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CCCACAAAGACTGCAGCTCTT	0.597													0	0	0	0.01441	0	86	218										T	62337724	C	T	62337724	2	4	89	1	0	0	0	0	0	0	0	1	856	564	20	2		2	ARFRP1	20	62337724	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	175463	62337724	687796	455	27033										
RGS19	10287	broad.mit.edu	37	chr20	62705211	62705211	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gctgctgggggcggcctaggCctcggaggaggactgtgatg	20	9	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62705211C>A	uc002yhy.2	-	6	916	c.649G>T	c.(649-651)GCC>TCC	p.A217S	RGS19_uc002yhz.2_Missense_Mutation_p.A195S|RGS19_uc002yia.2_Missense_Mutation_p.A217S|RGS19_uc002yib.2_Missense_Mutation_p.A217S	NM_005873	NP_005864	P49795	RGS19_HUMAN	G protein signalling regulator 19	217	Interaction with GIPC.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			skin(1)	1	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GCGGCCTAGGCCTCGGAGGAG	0.667													1	0	9.21137e-24	0.01441	1.15142e-23	68	33										A	62705211	C	A	62705211	3	1	89	1	0	0	0	0	1	0	0	0	13301	739	26	4	8	4	RGS19	20	62705211	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	367487	62705211	320309	456	27034										
ADAMTS5	11096	broad.mit.edu	37	chr21	28296648	28296649	+	Missense_Mutation	DNP	GG	GG	TT													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cggacatctaatggtttagtGgggtctgttgcaagaatctg							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:28296648_28296649GG>TT	uc002ymg.2	-	8	3245_3246	c.2516_2517CC>AA	c.(2515-2517)CCC>CAA	p.P839Q		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	839	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						ATGGTTTAGTGGGGTCTGTTGC	0.45													0	0	0	0.004672	0	55	99										TT	28296649	GG	TT	28296648	3	4	89	1	0	0	0	0	1	0	0	0	269	1335	47	4	279	4	ADAMTS5	21	28296648	Missense_Mutation	DNP	GG	TCGA-FJ-A3ZE-01A-11D-A23M-08		28296648	19833247	457	27035										
HUNK	30811	broad.mit.edu	37	chr21	33297057	33297057	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgtagagcacctgcaccgggCcggggtggtccacaggtaag	16	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:33297057C>T	uc002yph.2	+	2	899	c.539C>T	c.(538-540)GCC>GTC	p.A180V		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	180	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CTGCACCGGGCCGGGGTGGTC	0.612													0	0	0	0.01441	0	59	66										T	33297057	C	T	33297057	3	4	89	1	0	0	0	0	1	0	0	0	7458	739	26	2	545	2	HUNK	21	33297057	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5000409	33297057	14832838	458	27036										
MORC3	23515	broad.mit.edu	37	chr21	37721694	37721694	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	taaacaagatttcgactataCtaatgagtacaggtatgtta	7	5	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:37721694C>A	uc002yvi.2	+	9	1167	c.1091C>A	c.(1090-1092)ACT>AAT	p.T364N		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	364					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						TTCGACTATACTAATGAGTAC	0.328													1	0	1.99824e-07	0.00499	2.09645e-07	17	20										A	37721694	C	A	37721694	3	1	89	1	0	0	0	0	1	0	0	0	9703	565	20	4	1125	4	MORC3	21	37721694	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	4424637	37721694	10408201	459	27037										
LCA5L	150082	broad.mit.edu	37	chr21	40795035	40795035	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	agatatctttagtcttcagtAactggctgtcagtttctcta	7	8	5	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:40795035A>G	uc002yxu.2	-	5	1017	c.704T>C	c.(703-705)TTA>TCA	p.L235S	LCA5L_uc002yxv.2_Missense_Mutation_p.L235S|LCA5L_uc002yxw.1_Missense_Mutation_p.L235S|LCA5L_uc002yxx.1_Missense_Mutation_p.L97S|LCA5L_uc002yxy.2_RNA	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	235	Potential.										0		Prostate(19;1.2e-06)				AGTCTTCAGTAACTGGCTGTC	0.353													0	0	0	0.007835	0	39	55										G	40795035	A	G	40795035	3	3	89	1	0	0	0	0	1	0	0	0	8657	372	13	5	1332	5	LCA5L	21	40795035	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	3073341	40795035	7334860	460	27038										
TMPRSS2	7113	broad.mit.edu	37	chr21	42845396	42845396	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	cgcccacaatcctgctctggCggcttgagttcaagttgacc	10	14	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:42845396C>A	uc002yzj.2	-	9	889	c.755G>T	c.(754-756)CGC>CTC	p.R252L	TMPRSS2_uc010gor.2_Missense_Mutation_p.R289L|TMPRSS2_uc010gos.1_Missense_Mutation_p.R252L	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	252	Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CCTGCTCTGGCGGCTTGAGTT	0.687			T	ERG|ETV1|ETV4|ETV5	prostate 								1	0	3.45872e-05	0.004007	3.54168e-05	5	12										A	42845396	C	A	42845396	3	1	89	1	0	0	0	0	1	0	0	0	16244	768	27	4	747	4	TMPRSS2	21	42845396	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	2050361	42845396	5284499	461	27039										
ARVCF	421	broad.mit.edu	37	chr22	19965049	19965049	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctggtacctgtcggccccggGcacctccttgtgcacgtggt	13	15	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:19965049G>T	uc002zqz.2	-	9	2030	c.1759C>A	c.(1759-1761)CCC>ACC	p.P587T	ARVCF_uc002zqy.2_Missense_Mutation_p.P109T	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	587	ARM 6.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TCGGCCCCGGGCACCTCCTTG	0.677													1	0	2.17656e-39	0.01441	2.96803e-39	62	67										T	19965049	G	T	19965049	3	4	89	1	0	0	0	0	1	0	0	0	1003	1203	42	4	1173	4	ARVCF	22	19965049	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		19965049	31339517	462	27040										
RAB36	9609	broad.mit.edu	37	chr22	23495282	23495282	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tggggtggactttgaaattgAgcgctttgagattgctggga	16	4	0	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23495282A>G	uc002zwv.1	+	5	528	c.488A>G	c.(487-489)GAG>GGG	p.E163G	RAB36_uc010gtw.1_Missense_Mutation_p.E141G	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	163					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		TTTGAAATTGAGCGCTTTGAG	0.507													0	0	0	0.01441	0	69	98										G	23495282	A	G	23495282	3	3	89	1	0	0	0	0	1	0	0	0	12926	304	11	5	506	5	RAB36	22	23495282	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	3530233	23495282	27809284	463	27041										
BCR	613	broad.mit.edu	37	chr22	23626223	23626223	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gtggagggggcccgcaagctGcgccacgtcttcctgttcac	14	14	2	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23626223G>C	uc002zww.2	+	9	2771	c.2175G>C	c.(2173-2175)CTG>CTC	p.L725L	BCR_uc002zwx.2_Silent_p.L725L|BCR_uc011aiy.1_Silent_p.L314L|BCR_uc010gtx.1_Silent_p.L192L|BCR_uc002zwy.1_Silent_p.L11L	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	725	PH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						CCCGCAAGCTGCGCCACGTCT	0.657			T	ABL1| FGFR1|JAK2 	CML|ALL|AML								0	0	0	0.009096	0	4	10										C	23626223	G	C	23626223	2	2	89	1	0	0	0	0	0	0	0	1	1388	1306	46	4		4	BCR	22	23626223	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	130941	23626223	27678343	464	27042										
MTMR3	8897	broad.mit.edu	37	chr22	30416019	30416019	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggggagaggattccctggagGtccctgtggagcagtttcga	17	8	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:30416019G>T	uc003agv.3	+	17	2699	c.2371G>T	c.(2371-2373)GTC>TTC	p.V791F	MTMR3_uc003agu.3_Missense_Mutation_p.V791F|MTMR3_uc003agw.3_Missense_Mutation_p.V791F	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	791					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TTCCCTGGAGGTCCCTGTGGA	0.537													1	0	6.4771e-29	0.010771	8.51846e-29	45	64										T	30416019	G	T	30416019	3	4	89	1	0	0	0	0	1	0	0	0	9945	1261	44	4	2429	4	MTMR3	22	30416019	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	6789796	30416019	20888547	465	27043										
RNF215	200312	broad.mit.edu	37	chr22	30780398	30780398	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	catagccatccttggagaggCcacaggtggtccacaaggtc	12	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:30780398C>T	uc003ahp.2	-	5	674	c.674G>A	c.(673-675)GGC>GAC	p.G225D	RNF215_uc011akw.1_Missense_Mutation_p.G130D	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	225	Extracellular (Potential).					integral to membrane	zinc ion binding			central_nervous_system(1)	1						CTTGGAGAGGCCACAGGTGGT	0.602													0	0	0	0.009718	0	42	45										T	30780398	C	T	30780398	3	4	89	1	0	0	0	0	1	0	0	0	13479	739	26	2	479	2	RNF215	22	30780398	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	364379	30780398	20524168	466	27044										
SMTN	6525	broad.mit.edu	37	chr22	31491427	31491427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgactattgaggatgaaggaGtcttggacaagatggtatag	14	3	1	4			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:31491427G>A	uc003ajl.1	+	12	1989	c.1771G>A	c.(1771-1773)GTC>ATC	p.V591I	SMTN_uc003ajk.1_Missense_Mutation_p.V591I|SMTN_uc003ajm.1_Missense_Mutation_p.V591I|SMTN_uc011ale.1_Missense_Mutation_p.V676I|SMTN_uc011alf.1_Missense_Mutation_p.V647I|SMTN_uc003ajn.1_Missense_Mutation_p.V614I|SMTN_uc011alg.1_Missense_Mutation_p.V47I|SMTN_uc003ajo.1_Missense_Mutation_p.V190I|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Missense_Mutation_p.V47I	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	591					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						GGATGAAGGAGTCTTGGACAA	0.582													0	0	0	0.004656	0	24	26										A	31491427	G	A	31491427	3	1	89	1	0	0	0	0	1	0	0	0	14814	1029	36	2	1813	2	SMTN	22	31491427	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	711029	31491427	19813139	467	27045										
NCF4	4689	broad.mit.edu	37	chr22	37266564	37266564	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccccaggcactccgccggctCcgcccgcgcacccggaaagt	11	21	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:37266564C>G	uc003apy.3	+	5	634	c.450C>G	c.(448-450)CTC>CTG	p.L150L	NCF4_uc003apz.3_Silent_p.L150L	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	150					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						TCCGCCGGCTCCGCCCGCGCA	0.617													0	0	0	0.006999	0	33	54										G	37266564	C	G	37266564	2	3	89	1	0	0	0	0	0	0	0	1	10218	842	30	1		1	NCF4	22	37266564	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5775137	37266564	14038002	468	27046										
PNPLA3	80339	broad.mit.edu	37	chr22	44332964	44332964	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	gccccagccaggcctgaagtCatcctcagaagggatggatc	12	13	2	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:44332964C>T	uc003bei.1	+	6	964	c.791C>T	c.(790-792)TCA>TTA	p.S264L	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	264	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				GGCCTGAAGTCATCCTCAGAA	0.602													0	0	0	0.016522	0	23	36										T	44332964	C	T	44332964	3	4	89	1	0	0	0	0	1	0	0	0	12166	838	29	1	813	1	PNPLA3	22	44332964	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	7066400	44332964	6971602	469	27047										
C22orf9	23313	broad.mit.edu	37	chr22	45601541	45601541	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ttcttatggatgtgaatgtcCccgccgtcagcacgtgtgca	11	11	2	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:45601541C>T	uc003bfx.1	-	4	450	c.384G>A	c.(382-384)GGG>GGA	p.G128G	C22orf9_uc010gzw.1_Intron|C22orf9_uc003bfv.1_Silent_p.G137G|C22orf9_uc003bfw.1_Silent_p.G133G|C22orf9_uc010gzx.2_Silent_p.G110G	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	128							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		TGTGAATGTCCCCGCCGTCAG	0.612													0	0	0	0.009535	0	29	43										T	45601541	C	T	45601541	2	4	89	1	0	0	0	0	0	0	0	1	2151	610	22	2		2	C22orf9	22	45601541	Silent	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	1268577	45601541	5703025	470	27048										
TUBGCP6	85378	broad.mit.edu	37	chr22	50658876	50658876	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tgtgctcccaggctgagcgcTgactgggacgtgtggccagg	17	11	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:50658876T>C	uc003bkb.1	-	16	4424	c.3912A>G	c.(3910-3912)TCA>TCG	p.S1304S	TUBGCP6_uc003bka.1_Silent_p.S391S|TUBGCP6_uc010har.1_Silent_p.S1296S|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1304					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GGCTGAGCGCTGACTGGGACG	0.682													0	0	0	0.004007	0	15	26										C	50658876	T	C	50658876	2	2	89	1	0	0	0	0	0	0	0	1	16767	1567	55	5		5	TUBGCP6	22	50658876	Silent	SNP	T	TCGA-FJ-A3ZE-01A-11D-A23M-08	5057335	50658876	645690	471	27049										
MAPK12	6300	broad.mit.edu	37	chr22	50694610	50694610	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ctcactgtctgcctgcctggCcaggccgaagtccaggatct	11	15	3	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:50694610C>G	uc003bkm.1	-	7	674	c.523G>C	c.(523-525)GCC>CCC	p.A175P	MAPK12_uc003bkn.2_5'UTR|MAPK12_uc003bko.2_Missense_Mutation_p.A85P|MAPK12_uc003bkl.1_Missense_Mutation_p.A165P|MAPK12_uc003bkp.2_5'Flank|MAPK12_uc003bkq.2_5'UTR	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	175	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCTGCCTGGCCAGGCCGAAG	0.637													0	0	0	0.005443	0	27	46										G	50694610	C	G	50694610	3	3	89	1	0	0	0	0	1	0	0	0	9274	739	26	4	604	4	MAPK12	22	50694610	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	35734	50694610	609956	472	27050										
MAPK8IP2	23542	broad.mit.edu	37	chr22	51044009	51044009	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggttcatcccgcggcatccaGacgagctggagctggatgtg	15	11	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:51044009G>T	uc003bmx.2	+	8	1978	c.1861G>T	c.(1861-1863)GAC>TAC	p.D621Y	MAPK8IP2_uc003bmy.2_Missense_Mutation_p.D594Y|MAPK8IP2_uc011asc.1_5'UTR	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	621	SH3.				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCGGCATCCAGACGAGCTGGA	0.652													1	0	0.00198382	0.001984	0.00200185	7	9										T	51044009	G	T	51044009	3	4	89	1	0	0	0	0	1	0	0	0	9285	942	33	3	1976	3	MAPK8IP2	22	51044009	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	349399	51044009	260557	473	27051										
TLR8	51311	broad.mit.edu	37	chrX	12939700	12939700	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	atggttatgttggctgccctGgctcaccatttgttttactg	10	9	1	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:12939700G>C	uc004cve.2	+	2	2609	c.2541G>C	c.(2539-2541)CTG>CTC	p.L847L	TLR8_uc004cvd.2_Silent_p.L865L	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	847	Helical; (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TGGCTGCCCTGGCTCACCATT	0.393													0	0	0	0.01441	0	67	9										C	12939700	G	C	12939700	2	2	89	1	0	0	0	0	0	0	0	1	15954	1335	47	4		4	TLR8	23	12939700	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08		12939700	142330860	474	27052										
CDKL5	6792	broad.mit.edu	37	chrX	18622501	18622501	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tccctcctacaggaccaaggCcaaaagccatggggcactga	10	14	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:18622501C>A	uc004cym.2	+	12	1710	c.1457C>A	c.(1456-1458)GCC>GAC	p.A486D	CDKL5_uc004cyn.2_Missense_Mutation_p.A486D	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	486					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					AGGACCAAGGCCAAAAGCCAT	0.532													1	0	3.8688e-20	0.01441	4.68818e-20	65	11										A	18622501	C	A	18622501	3	1	89	1	0	0	0	0	1	0	0	0	3157	739	26	4	1499	4	CDKL5	23	18622501	Missense_Mutation	SNP	C	TCGA-FJ-A3ZE-01A-11D-A23M-08	5682801	18622501	136648059	475	27053										
CDKL5	6792	broad.mit.edu	37	chrX	18622521	18622521	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ccaaaagccatggggcactgAgtgactccaagtctgtgagc	12	11	1	3			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:18622521A>G	uc004cym.2	+	12	1730	c.1477A>G	c.(1477-1479)AGT>GGT	p.S493G	CDKL5_uc004cyn.2_Missense_Mutation_p.S493G	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	493					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					TGGGGCACTGAGTGACTCCAA	0.517													0	0	0	0.01441	0	60	11										G	18622521	A	G	18622521	3	3	89	1	0	0	0	0	1	0	0	0	3157	304	11	5	1519	5	CDKL5	23	18622521	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	20	18622521	136648039	476	27054										
MAGEB18	286514	broad.mit.edu	37	chrX	26157994	26157994	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tacatgataccgtccctagtGccttcccatcctgctatgaa	6	14	0	2			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:26157994G>T	uc004dbq.1	+	2	1079	c.892G>T	c.(892-894)GCC>TCC	p.A298S		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	298	MAGE.						protein binding			central_nervous_system(1)	1						CGTCCCTAGTGCCTTCCCATC	0.522													1	0	5.16669e-11	0.010729	5.67824e-11	12	1										T	26157994	G	T	26157994	3	4	89	1	0	0	0	0	1	0	0	0	9175	1319	46	4	894	4	MAGEB18	23	26157994	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	7535473	26157994	129112566	477	27055										
KDM6A	7403	broad.mit.edu	37	chrX	44918557	44918558	+	Frame_Shift_Ins	INS	-	-	G													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tatatttgtgctgtacaattINSggaccatggccatgctgcag							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:44918557_44918558insG	uc004dge.3	+	12	1415_1416	c.1040_1041insG	c.(1039-1041)TTGfs	p.L347fs	KDM6A_uc010nhk.2_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mkz.1_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mla.1_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mlb.1_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mlc.1_Frame_Shift_Ins_p.L96fs|KDM6A_uc011mld.1_Frame_Shift_Ins_p.L13fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	347	TPR 7.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GCTGTACAATTGGACCATGGCC	0.431			D|N|F|S		renal|oesophageal SCC|MM													39	9	---	---								G	44918558	-	G	44918557	7	5	89	1	0	1	1	0	0	0	0	0	8137	1821	63	0	1086	0	KDM6A	23	44918557	Frame_Shift_Ins	INS	-	TCGA-FJ-A3ZE-01A-11D-A23M-08	18760563	44918557	110352003	478	27056										
ZXDA	7789	broad.mit.edu	37	chrX	57936038	57936038	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggcgaaggtttgcccgcacaGcgcctcggggcacaggtaca	15	13	0	0			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:57936038G>A	uc004dve.2	-	1	1030	c.817C>T	c.(817-819)CTG>TTG	p.L273L		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	273	C2H2-type 1.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGCCCGCACAGCGCCTCGGGG	0.711													0	0	0	0.006214	0	7	2										A	57936038	G	A	57936038	2	1	89	1	0	0	0	0	0	0	0	1	18247	962	34	2		2	ZXDA	23	57936038	Silent	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	13017481	57936038	97334522	479	27057										
OTUD6A	139562	broad.mit.edu	37	chrX	69282757	69282757	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggccggcttcaagcgcgaggAggaggagaagctcgccgcca	17	12	1	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:69282757A>T	uc004dxu.1	+	1	417	c.383A>T	c.(382-384)GAG>GTG	p.E128V		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	128										lung(1)|skin(1)	2						AAGCGCGAGGAGGAGGAGAAG	0.627													0	0	0	0.001168	0	6	1										T	69282757	A	T	69282757	3	4	89	1	0	0	0	0	1	0	0	0	11316	304	11	5	385	5	OTUD6A	23	69282757	Missense_Mutation	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	11346719	69282757	85987803	480	27058										
ATP7A	538	broad.mit.edu	37	chrX	77271359	77271359	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	attgaaggacattctatggtAgatgagtccctcatcacagg	10	8	3	3	rs61053012	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:77271359A>G	uc004ecx.3	+	12	2767	c.2607A>G	c.(2605-2607)GTA>GTG	p.V869V		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	869	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						ATTCTATGGTAGATGAGTCCC	0.378													0	0	0	0.01441	0	60	1										G	77271359	A	G	77271359	2	3	89	1	0	0	0	0	0	0	0	1	1190	407	15	5		5	ATP7A	23	77271359	Silent	SNP	A	TCGA-FJ-A3ZE-01A-11D-A23M-08	7988602	77271359	77999201	481	27059										
STAG2	10735	broad.mit.edu	37	chrX	123184129	123184130	+	Frame_Shift_Del	DEL	AA	AA	-													0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	tttcttaatgacagttatttAaaatatgttggttggactat							TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			AA	-	AA	AA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:123184129_123184130delAA	uc004etz.3	+	10	1326_1327	c.987_988delAA	c.(985-990)TTAAAAfs	p.L329fs	STAG2_uc004eua.2_Frame_Shift_Del_p.L329fs|STAG2_uc004eub.2_Frame_Shift_Del_p.L329fs|STAG2_uc004euc.2_Frame_Shift_Del_p.L329fs|STAG2_uc004eud.2_Frame_Shift_Del_p.L329fs|STAG2_uc004eue.2_Frame_Shift_Del_p.L329fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	329_330	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						ACAGTTATTTAAAATATGTTGG	0.401																		141	18	---	---								-	123184130	AA	-	123184129	7	5	89	1	0	1	0	1	0	0	0	0	15242	359	13	0	1021	0	STAG2	23	123184129	Frame_Shift_Del	DEL	AA	TCGA-FJ-A3ZE-01A-11D-A23M-08	45912770	123184129	32086431	482	27060										
PLXNB3	5365	broad.mit.edu	37	chrX	153037013	153037013	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0850622406639004	41	0.0189071777300011	1.40434106955846	2.30431818181818	0.936820491761203	0.432891340023628	0.656703672938893	12	ggccaacaggagcctgggctGcctgtggtgtgctgacggcc	17	12	0	1			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:153037013G>A	uc004fii.2	+	14	2594	c.2420G>A	c.(2419-2421)TGC>TAC	p.C807Y	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Missense_Mutation_p.C489Y|PLXNB3_uc010nuk.2_Missense_Mutation_p.C830Y|PLXNB3_uc011mzd.1_Missense_Mutation_p.C446Y|PLXNB3_uc004fij.1_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	807	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCCTGGGCTGCCTGTGGTGT	0.672													0	0	0	0.008361	0	29	0										A	153037013	G	A	153037013	3	1	89	1	0	0	0	0	1	0	0	0	12125	1319	46	2	2588	2	PLXNB3	23	153037013	Missense_Mutation	SNP	G	TCGA-FJ-A3ZE-01A-11D-A23M-08	29852884	153037013	2233547	483	27061										
ACAP3	116983	broad.mit.edu	37	chr1	1233212	1233212	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agggccacacctcgctatagCaactgtcagggctctcgcgg	12	14	2	0	rs146361230		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:1233212C>G	uc001aeb.2	-	14	1192	c.1118G>C	c.(1117-1119)TGC>TCC	p.C373S	ACAP3_uc001ady.2_Missense_Mutation_p.C103S|ACAP3_uc001aea.2_Missense_Mutation_p.C331S	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	373					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						CTCGCTATAGCAACTGTCAGG	0.682													0	0	0	0.013726	0	34	18										G	1233212	C	G	1233212	3	3	90	1	0	0	0	0	1	0	0	0	120	710	25	4	1430	4	ACAP3	1	1233212	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		1233212	248017409	1	27062										
SSU72	29101	broad.mit.edu	37	chr1	1479272	1479272	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctggcagagctcacagatgaGaaacgcccccagggtggcct	13	13	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:1479272G>A	uc001agd.2	-	4	785	c.460C>T	c.(460-462)CTC>TTC	p.L154F	SSU72_uc009vkg.1_Missense_Mutation_p.L154F	NM_014188	NP_054907	Q9NP77	SSU72_HUMAN	Ssu72 RNA polymerase II CTD phosphatase homolog	154					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity				0	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TCACAGATGAGAAACGCCCCC	0.517													0	0	0	0.003755	0	36	101										A	1479272	G	A	1479272	3	1	90	1	0	0	0	0	1	0	0	0	15201	942	33	1	132	1	SSU72	1	1479272	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	246060	1479272	247771349	2	27063										
MMEL1	79258	broad.mit.edu	37	chr1	2529730	2529730	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aggcgccagaccaggtagttCtgtatggtcctgggggcaga	16	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:2529730C>T	uc001ajy.2	-	13	1402	c.1188G>A	c.(1186-1188)CAG>CAA	p.Q396Q	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	396	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CCAGGTAGTTCTGTATGGTCC	0.582													0	0	0	0.008871	0	20	56										T	2529730	C	T	2529730	2	4	90	1	0	0	0	0	0	0	0	1	9646	912	32	1		1	MMEL1	1	2529730	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1050458	2529730	246720891	3	27064										
MMEL1	79258	broad.mit.edu	37	chr1	2530149	2530149	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgcaggtaggggatgccataGaccaccacttcctcatctgg	11	12	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:2530149G>C	uc001ajy.2	-	12	1336	c.1122C>G	c.(1120-1122)GTC>GTG	p.V374V	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	374	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GGATGCCATAGACCACCACTT	0.517													0	0	0	0.012319	0	21	72										C	2530149	G	C	2530149	2	2	90	1	0	0	0	0	0	0	0	1	9646	929	33	1		1	MMEL1	1	2530149	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	419	2530149	246720472	4	27065										
PINK1	65018	broad.mit.edu	37	chr1	20972086	20972086	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgcgccagtacctttgtgtGaacacacccagcccccgcct	8	18	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:20972086G>A	uc001bdm.2	+	5	1087	c.993G>A	c.(991-993)GTG>GTA	p.V331V	PINK1_uc001bdn.2_Silent_p.V24V	NM_032409	NP_115785	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1 precursor	331	Protein kinase.|Cytoplasmic (Potential).				cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			ovary(2)|central_nervous_system(1)	3		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACCTTTGTGTGAACACACCCA	0.577													0	0	0	0.003954	0	24	54										A	20972086	G	A	20972086	2	1	90	1	0	0	0	0	0	0	0	1	11932	1277	45	1		1	PINK1	1	20972086	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	18441937	20972086	228278535	5	27066										
ARID1A	8289	broad.mit.edu	37	chr1	27106421	27106421	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccagggctgctgctcatccTgggcaagctgatcctgctgc	12	15	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:27106421T>G	uc001bmv.1	+	20	6405	c.6032T>G	c.(6031-6033)CTG>CGG	p.L2011R	ARID1A_uc001bmu.1_Missense_Mutation_p.L1794R|ARID1A_uc001bmx.1_Missense_Mutation_p.L857R|ARID1A_uc009vsm.1_Missense_Mutation_p.L339R|ARID1A_uc009vsn.1_Missense_Mutation_p.L253R	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2011					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTGCTCATCCTGGGCAAGCTG	0.547			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.003755	0	35	77										G	27106421	T	G	27106421	3	3	90	1	0	0	0	0	1	0	0	0	913	1580	55	5	6110	5	ARID1A	1	27106421	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	6134335	27106421	222144200	6	27067										
MAP3K6	9064	broad.mit.edu	37	chr1	27683085	27683085	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttccaaggggctttaccgatCagtctctgccctcaagaggc	10	13	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:27683085C>G	uc001bny.1	-	25	3769	c.3520G>C	c.(3520-3522)GAT>CAT	p.D1174H	MAP3K6_uc009vsw.1_Missense_Mutation_p.D1166H	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1174	Potential.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTTTACCGATCAGTCTCTGCC	0.647													0	0	0	0.004482	0	9	53										G	27683085	C	G	27683085	3	3	90	1	0	0	0	0	1	0	0	0	9254	826	29	1	366	1	MAP3K6	1	27683085	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	576664	27683085	221567536	7	27068										
KIAA1522	57648	broad.mit.edu	37	chr1	33236326	33236326	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agcggggcttagcagtgcctGatgggccattagggttgccc	16	10	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:33236326G>C	uc001bvv.2	+	6	1505	c.1369G>C	c.(1369-1371)GAT>CAT	p.D457H	KIAA1522_uc001bvu.1_Missense_Mutation_p.D516H|KIAA1522_uc010ohm.1_Missense_Mutation_p.D468H|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	457	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGCAGTGCCTGATGGGCCATT	0.682													0	0	0	0.010729	0	12	27										C	33236326	G	C	33236326	3	2	90	1	0	0	0	0	1	0	0	0	8238	1290	45	1	1568	1	KIAA1522	1	33236326	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5553241	33236326	216014295	8	27069										
STIL	6491	broad.mit.edu	37	chr1	47753284	47753284	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgtttctgcattttggctttCagcgctcagttcacaacgga	9	10	4	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:47753284C>T	uc001crc.1	-	10	1227	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.E311K|STIL_uc010omo.1_Missense_Mutation_p.E358K|STIL_uc001crd.1_Missense_Mutation_p.E358K|STIL_uc001cre.1_Missense_Mutation_p.E358K|STIL_uc001crg.1_Missense_Mutation_p.E311K	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	358					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTTTGGCTTTCAGCGCTCAGT	0.333													0	0	0	0.00632	0	25	26										T	47753284	C	T	47753284	3	4	90	1	0	0	0	0	1	0	0	0	15281	835	29	1	2826	1	STIL	1	47753284	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	14516958	47753284	201497337	9	27070										
MAGOH	4116	broad.mit.edu	37	chr1	53699227	53699227	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aacacacctgccggcccactCggtcaggaggaggccacaat	11	15	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:53699227C>T	uc001cvf.1	-	3	333	c.245G>A	c.(244-246)CGA>CAA	p.R82Q	MAGOH_uc010ont.1_Intron	NM_002370	NP_002361	P61326	MGN_HUMAN	mago-nashi homolog	82					mRNA 3'-end processing|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|exon-exon junction complex|nuclear speck	protein binding|RNA binding				0						CCGGCCCACTCGGTCAGGAGG	0.453													0	0	0	0.01441	0	88	85										T	53699227	C	T	53699227	3	4	90	1	0	0	0	0	1	0	0	0	9194	884	31	1	207	1	MAGOH	1	53699227	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	5945943	53699227	195551394	10	27071										
PTPN22	26191	broad.mit.edu	37	chr1	114380326	114380326	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgtagaggatgttggcaacaGagaagaaggaaaaacagttc	13	4	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:114380326G>A	uc001eds.2	-	13	1826	c.1696C>T	c.(1696-1698)CTG>TTG	p.L566L	PTPN22_uc009wgq.2_Silent_p.L511L|PTPN22_uc010owo.1_Silent_p.L322L|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Silent_p.L566L|PTPN22_uc009wgs.2_Silent_p.L439L|PTPN22_uc001edu.2_Silent_p.L566L	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	566					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTGGCAACAGAGAAGAAGGA	0.383													0	0	0	0.01441	0	77	45										A	114380326	G	A	114380326	2	1	90	1	0	0	0	0	0	0	0	1	12787	933	33	1		1	PTPN22	1	114380326	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	60681099	114380326	134870295	11	27072										
HSD3B1	3283	broad.mit.edu	37	chr1	120056930	120056930	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atatctcagatgacacgcctCaccaaagctatgataacctt	5	12	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:120056930C>T	uc001ehv.1	+	4	929	c.784C>T	c.(784-786)CAC>TAC	p.H262Y	HSD3B1_uc001ehw.2_Missense_Mutation_p.H264Y	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	262					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	TGACACGCCTCACCAAAGCTA	0.522													0	0	0	0.01441	0	136	64										T	120056930	C	T	120056930	3	4	90	1	0	0	0	0	1	0	0	0	7390	826	29	1	794	1	HSD3B1	1	120056930	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	5676604	120056930	129193691	12	27073										
TARS2	80222	broad.mit.edu	37	chr1	150479406	150479406	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgcagtggttggccagaaaGagcaaagtaagagaacagtg	14	6	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:150479406G>A	uc001euq.2	+	18	2030	c.2023G>A	c.(2023-2025)GAG>AAG	p.E675K	TARS2_uc001eur.2_Missense_Mutation_p.E593K|TARS2_uc009wlt.2_Missense_Mutation_p.E301K|TARS2_uc009wls.2_Missense_Mutation_p.E545K|ECM1_uc010pce.1_5'Flank|ECM1_uc010pcf.1_5'Flank|ECM1_uc001eus.2_5'Flank|ECM1_uc001eut.2_5'Flank|ECM1_uc001euu.2_5'Flank|ECM1_uc001euv.2_5'Flank|ECM1_uc009wlu.2_5'Flank	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	675					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TGGCCAGAAAGAGCAAAGTAA	0.507													0	0	0	0.010818	0	29	188										A	150479406	G	A	150479406	3	1	90	1	0	0	0	0	1	0	0	0	15557	943	33	1	2093	1	TARS2	1	150479406	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	30422476	150479406	98771215	13	27074										
TARS2	80222	broad.mit.edu	37	chr1	150479442	150479442	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cagtgaacattcggactcgaGataatcgtcgccttggggag	13	9	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:150479442G>A	uc001euq.2	+	18	2066	c.2059G>A	c.(2059-2061)GAT>AAT	p.D687N	TARS2_uc001eur.2_Missense_Mutation_p.D605N|TARS2_uc009wlt.2_Missense_Mutation_p.D313N|TARS2_uc009wls.2_Missense_Mutation_p.D557N|ECM1_uc010pce.1_5'Flank|ECM1_uc010pcf.1_5'Flank|ECM1_uc001eus.2_5'Flank|ECM1_uc001eut.2_5'Flank|ECM1_uc001euu.2_5'Flank|ECM1_uc001euv.2_5'Flank|ECM1_uc009wlu.2_5'Flank	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	687					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TCGGACTCGAGATAATCGTCG	0.522													0	0	0	0.012213	0	35	186										A	150479442	G	A	150479442	3	1	90	1	0	0	0	0	1	0	0	0	15557	942	33	1	2129	1	TARS2	1	150479442	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	36	150479442	98771179	14	27075										
CKS1B	1163	broad.mit.edu	37	chr1	154951211	154951211	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	actctttcagaacctcacatCttgctgttccggcgcccact	6	16	4	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:154951211C>T	uc001fgb.2	+	3	302	c.198C>T	c.(196-198)ATC>ATT	p.I66I	CKS1B_uc001fga.2_RNA	NM_001826	NP_001817	P61024	CKS1_HUMAN	CDC28 protein kinase 1B	66					cell division|cell proliferation|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	nucleoplasm	cyclin-dependent protein kinase regulator activity|protein binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AACCTCACATCTTGCTGTTCC	0.458													0	0	0	0.01441	0	48	3										T	154951211	C	T	154951211	2	4	90	1	0	0	0	0	0	0	0	1	3452	903	32	1		1	CKS1B	1	154951211	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	4471769	154951211	94299410	15	27076										
DCST2	127579	broad.mit.edu	37	chr1	154995910	154995910	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcaggtattgtccaggaggcGgaagcaagtgaggcagtaga	17	6	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:154995910G>A	uc001fgm.2	-	13	1974	c.1894C>T	c.(1894-1896)CGC>TGC	p.R632C	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	632	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCCAGGAGGCGGAAGCAAGTG	0.612													0	0	0	0.006214	0	8	25										A	154995910	G	A	154995910	3	1	90	1	0	0	0	0	1	0	0	0	4303	1116	39	2	439	2	DCST2	1	154995910	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	44699	154995910	94254711	16	27077										
DCST2	127579	broad.mit.edu	37	chr1	154998788	154998788	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gacccctcacctgctcccggGatgggtagtaggaggcacag	14	13	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:154998788G>A	uc001fgm.2	-	10	1681	c.1601C>T	c.(1600-1602)TCC>TTC	p.S534F	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	534	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGCTCCCGGGATGGGTAGTA	0.617													0	0	0	0.009535	0	26	120										A	154998788	G	A	154998788	3	1	90	1	0	0	0	0	1	0	0	0	4303	1174	41	1	744	1	DCST2	1	154998788	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	2878	154998788	94251833	17	27078										
CD5L	922	broad.mit.edu	37	chr1	157803224	157803224	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agttgtcatcacagacagagCcccatacgcccttgtgcagc	9	14	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:157803224C>G	uc001frk.3	-	5	940	c.797G>C	c.(796-798)GGC>GCC	p.G266A		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	266	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACAGACAGAGCCCCATACGCC	0.567													0	0	0	0.01441	0	47	129										G	157803224	C	G	157803224	3	3	90	1	0	0	0	0	1	0	0	0	3027	739	26	4	254	4	CD5L	1	157803224	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2804436	157803224	91447397	18	27079										
ATP1A2	477	broad.mit.edu	37	chr1	160094202	160094202	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cctgctgacctccggatcatCtcttctcatggctgtaaggt	9	13	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:160094202C>G	uc001fvc.2	+	6	744	c.612C>G	c.(610-612)ATC>ATG	p.I204M	ATP1A2_uc001fvb.2_Missense_Mutation_p.I204M|ATP1A2_uc010piz.1_Missense_Mutation_p.I49M	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	204	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCCGGATCATCTCTTCTCATG	0.567													0	0	0	0.004482	0	9	38										G	160094202	C	G	160094202	3	3	90	1	0	0	0	0	1	0	0	0	1129	903	32	1	634	1	ATP1A2	1	160094202	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2290978	160094202	89156419	19	27080										
XPR1	9213	broad.mit.edu	37	chr1	180804041	180804041	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tacagcccccttccataaggTaggctttgctgatttctggc	9	12	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:180804041T>G	uc001goi.2	+	10	1358	c.1166T>G	c.(1165-1167)GTA>GGA	p.V389G	XPR1_uc009wxm.2_Missense_Mutation_p.V389G|XPR1_uc009wxn.2_Missense_Mutation_p.V389G	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	389	Helical; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						TTCCATAAGGTAGGCTTTGCT	0.403													0	0	0	0.00499	0	17	98										G	180804041	T	G	180804041	3	3	90	1	0	0	0	0	1	0	0	0	17448	1638	57	5	1204	5	XPR1	1	180804041	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	20709839	180804041	68446580	20	27081										
PRG4	10216	broad.mit.edu	37	chr1	186270750	186270750	+	Missense_Mutation	SNP	G	G	A													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cctgtaaaggccgctgctttGagtccttcgagagagggagg							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:186270750G>A	uc001gru.3	+	4	277	c.226G>A	c.(226-228)GAG>AAG	p.E76K	PRG4_uc001grt.3_Missense_Mutation_p.E35K|PRG4_uc009wyl.2_Missense_Mutation_p.E76K|PRG4_uc009wym.2_Missense_Mutation_p.E35K|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	76	SMB 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCGCTGCTTTGAGTCCTTCGA	0.448													0	0	0	0.01441	0	114	0										A	186270750	G	A	186270750	3	1	90	1	0	0	0	0	1	0	0	0	12481	1291	45	1	236	1	PRG4	1	186270750	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5466709	186270750	62979871	21	27082	132	2								
PRG4	10216	broad.mit.edu	37	chr1	186270756	186270756	+	Missense_Mutation	SNP	T	T	A													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aaggccgctgctttgagtccTtcgagagagggagggagtgt							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:186270756T>A	uc001gru.3	+	4	283	c.232T>A	c.(232-234)TTC>ATC	p.F78I	PRG4_uc001grt.3_Missense_Mutation_p.F37I|PRG4_uc009wyl.2_Missense_Mutation_p.F78I|PRG4_uc009wym.2_Missense_Mutation_p.F37I|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	78	SMB 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTTTGAGTCCTTCGAGAGAGG	0.463													0	0	0	0.01441	0	115	0										A	186270756	T	A	186270756	3	1	90	1	0	0	0	0	1	0	0	0	12481	1609	56	5	242	5	PRG4	1	186270756	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	6	186270756	62979865	22	27083	132	2								
KCNT2	343450	broad.mit.edu	37	chr1	196250089	196250089	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	taaagtctggcataagttctGatccataagtcatctgcagt	8	8	4	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:196250089G>A	uc001gtd.1	-	25	2871	c.2811C>T	c.(2809-2811)ATC>ATT	p.I937I	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.I863I|KCNT2_uc001gtf.1_Silent_p.I913I|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.I913I|KCNT2_uc001gth.1_Silent_p.I434I	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	937	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CATAAGTTCTGATCCATAAGT	0.343													0	0	0	0.01441	0	91	2										A	196250089	G	A	196250089	2	1	90	1	0	0	0	0	0	0	0	1	8092	1280	45	1		1	KCNT2	1	196250089	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	9979333	196250089	53000532	23	27084										
ELF3	1999	broad.mit.edu	37	chr1	201984345	201984345	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctcttcacccaggtactactAcaaacgggagatcctggaac	8	13	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:201984345A>G	uc001gxg.3	+	8	4202	c.1010A>G	c.(1009-1011)TAC>TGC	p.Y337C	ELF3_uc001gxi.3_Missense_Mutation_p.Y337C|ELF3_uc001gxh.3_Missense_Mutation_p.Y337C	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	337	ETS.			RYYY->AAAA: Partially abrogates repressive effect on the KRT4 promoter.	epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						AGGTACTACTACAAACGGGAG	0.597													0	0	0	0.01441	0	100	2										G	201984345	A	G	201984345	3	3	90	1	0	0	0	0	1	0	0	0	5055	391	14	5	1040	5	ELF3	1	201984345	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	5734256	201984345	47266276	24	27085										
AVPR1B	553	broad.mit.edu	37	chr1	206225298	206225298	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtgaagatgacctttgtcatCgtgctggcctacatcgcttg	11	10	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:206225298C>T	uc001hds.2	+	1	1016	c.858C>T	c.(856-858)ATC>ATT	p.I286I		NM_000707	NP_000698	P47901	V1BR_HUMAN	arginine vasopressin receptor 1B	286	Helical; Name=6; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			ovary(2)|large_intestine(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.0312)		Desmopressin(DB00035)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCTTTGTCATCGTGCTGGCCT	0.572													0	0	0	0.01441	0	72	54										T	206225298	C	T	206225298	2	4	90	1	0	0	0	0	0	0	0	1	1232	874	31	1		1	AVPR1B	1	206225298	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	4240953	206225298	43025323	25	27086										
PCNXL2	80003	broad.mit.edu	37	chr1	233134081	233134081	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgcgctgctctcctggctgcCaccactcggggcattgttgc	12	15	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:233134081C>G	uc001hvl.2	-	32	5942	c.5707G>C	c.(5707-5709)GGC>CGC	p.G1903R	PCNXL2_uc001hvk.1_Missense_Mutation_p.G555R|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1903						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TCCTGGCTGCCACCACTCGGG	0.637													0	0	0	0.00333	0	21	45										G	233134081	C	G	233134081	3	3	90	1	0	0	0	0	1	0	0	0	11592	594	21	4	718	4	PCNXL2	1	233134081	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	26908783	233134081	16116540	26	27087										
OR2T4	127074	broad.mit.edu	37	chr1	248525926	248525926	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcctttcaaaaagctatggaGtagaccattttgagagtaat	9	6	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr1:248525926G>A	uc001ieh.1	+	1	1044	c.1044G>A	c.(1042-1044)GAG>GAA	p.E348E		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	348	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAGCTATGGAGTAGACCATTT	0.403													0	0	0	0.01441	0	158	6										A	248525926	G	A	248525926	2	1	90	1	0	0	0	0	0	0	0	1	11027	1020	36	2		2	OR2T4	1	248525926	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	15391845	248525926	724695	27	27088										
ROCK2	9475	broad.mit.edu	37	chr2	11338883	11338883	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcaacatcactagttagtgtCctattagtttcctcaagcta	6	10	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:11338883C>T	uc002rbd.1	-	24	3377	c.2928G>A	c.(2926-2928)AGG>AGA	p.R976R		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	976	Potential.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TAGTTAGTGTCCTATTAGTTT	0.279													0	0	0	0.00245	0	11	33										T	11338883	C	T	11338883	2	4	90	1	0	0	0	0	0	0	0	1	13518	854	30	1		1	ROCK2	2	11338883	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		11338883	231860490	28	27089										
RHOB	388	broad.mit.edu	37	chr2	20647365	20647365	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agaactatgtggccgacattGaggtggacggcaagcaggtg	16	7	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:20647365G>A	uc002rdv.2	+	1	531	c.139G>A	c.(139-141)GAG>AAG	p.E47K		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	47					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GGCCGACATTGAGGTGGACGG	0.647													0	0	0	0.005443	0	28	101										A	20647365	G	A	20647365	3	1	90	1	0	0	0	0	1	0	0	0	13332	1291	45	1	141	1	RHOB	2	20647365	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	9308482	20647365	222552008	29	27090										
ZNF512	84450	broad.mit.edu	37	chr2	27825413	27825413	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctaaagagactgggaaagctCaggtgcatgcgtgaggtaag	15	6	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:27825413C>G	uc002rla.2	+	8	840	c.753C>G	c.(751-753)CTC>CTG	p.L251L	ZNF512_uc010ylv.1_Silent_p.L172L|ZNF512_uc010ylw.1_Silent_p.L222L|ZNF512_uc002rlb.2_Silent_p.L172L|ZNF512_uc010ylx.1_Silent_p.L172L|ZNF512_uc002rlc.2_Silent_p.L172L|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_Silent_p.L144L	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TGGGAAAGCTCAGGTGCATGC	0.463													0	0	0	0.004482	0	7	54										G	27825413	C	G	27825413	2	3	90	1	0	0	0	0	0	0	0	1	17953	813	29	1		1	ZNF512	2	27825413	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	7178048	27825413	215373960	30	27091										
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48874166	48874166	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atagaggaacccagcaacatAcctgtatcagagaaggtata	9	8	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:48874166A>G	uc010yol.1	+	5	2981	c.2934A>G	c.(2932-2934)ATA>ATG	p.I978M	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.I1025M|GTF2A1L_uc002rws.1_Missense_Mutation_p.I321M|GTF2A1L_uc010yom.1_Missense_Mutation_p.I287M|GTF2A1L_uc002rwt.2_Missense_Mutation_p.I321M	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	978					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCAGCAACATACCTGTATCAG	0.393													0	0	0	0.00278	0	23	53										G	48874166	A	G	48874166	3	3	90	1	0	0	0	0	1	0	0	0	15316	381	14	5	3101	5	STON1-GTF2A1L	2	48874166	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	21048753	48874166	194325207	31	27092										
NRXN1	9378	broad.mit.edu	37	chr2	50733754	50733754	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aaaagagtctcgggacctttGcctgtagaatatgccaaaca	9	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:50733754G>T	uc010fbq.2	-	13	3973	c.2496C>A	c.(2494-2496)AGC>AGA	p.S832R	NRXN1_uc002rxb.3_Missense_Mutation_p.S464R|NRXN1_uc002rxe.3_Missense_Mutation_p.S792R|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGGGACCTTTGCCTGTAGAAT	0.358													1	0	2.0095e-06	0.001984	2.08764e-06	7	66										T	50733754	G	T	50733754	3	4	90	1	0	0	0	0	1	0	0	0	10665	1333	46	4	2454	4	NRXN1	2	50733754	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1859588	50733754	192465619	32	27093										
EFEMP1	2202	broad.mit.edu	37	chr2	56144828	56144828	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acgttgtgttcactttgctcGtagcctgctgcacactggat	10	11	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:56144828G>C	uc002rzh.2	-	4	819	c.489C>G	c.(487-489)TAC>TAG	p.Y163*	EFEMP1_uc002rzi.2_Nonsense_Mutation_p.Y163*|EFEMP1_uc002rzj.2_Nonsense_Mutation_p.Y163*|EFEMP1_uc010ypc.1_Nonsense_Mutation_p.Y105*	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	163					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CACTTTGCTCGTAGCCTGCTG	0.507													0	0	0	0.01441	0	58	225										C	56144828	G	C	56144828	4	2	90	1	0	0	0	0	0	1	0	0	4941	1140	40	4	1024	4	EFEMP1	2	56144828	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5411074	56144828	187054545	33	27094										
FAM161A	84140	broad.mit.edu	37	chr2	62067209	62067209	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcttctttgcttttctccttCagagaccttctccgttcttc	5	14	5	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:62067209C>T	uc010ypo.1	-	3	1032	c.930G>A	c.(928-930)CTG>CTA	p.L310L	FAM161A_uc002sbm.3_Silent_p.L310L|FAM161A_uc002sbn.3_Silent_p.L120L|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Silent_p.L201L	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	310	Potential.				response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						TTTTCTCCTTCAGAGACCTTC	0.443													0	0	0	0.01441	0	62	268										T	62067209	C	T	62067209	2	4	90	1	0	0	0	0	0	0	0	1	5472	813	29	1		1	FAM161A	2	62067209	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	5922381	62067209	181132164	34	27095										
STAMBP	10617	broad.mit.edu	37	chr2	74074811	74074811	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttcagactgtcacacaactGtaaggccagctaagccacct	7	14	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:74074811G>T	uc002sjs.2	+	5	723	c.673G>T	c.(673-675)GTA>TTA	p.V225L	STAMBP_uc002sjt.2_Missense_Mutation_p.V225L|STAMBP_uc002sju.2_Missense_Mutation_p.V225L|STAMBP_uc002sjv.2_Missense_Mutation_p.V225L	NM_201647	NP_964010	O95630	STABP_HUMAN	STAM binding protein	225					JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			ovary(1)|lung(1)|breast(1)|pancreas(1)	4						TCACACAACTGTAAGGCCAGC	0.517													1	0	3.5997e-14	0.014323	3.891e-14	23	153										T	74074811	G	T	74074811	3	4	90	1	0	0	0	0	1	0	0	0	15249	1377	48	4	687	4	STAMBP	2	74074811	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	12007602	74074811	169124562	35	27096										
LRRTM1	347730	broad.mit.edu	37	chr2	80529551	80529551	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tttgcttcctgcgctgcgtgAcaaagcactgtctgagctgc	11	12	1	2	rs148119501	byFrequency	TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:80529551A>C	uc002sok.1	-	2	1664	c.1394T>G	c.(1393-1395)GTC>GGC	p.V465G	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	465	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCGCTGCGTGACAAAGCACTG	0.532										HNSCC(69;0.2)			0	0	0	0.014323	0	20	126										C	80529551	A	C	80529551	3	2	90	1	0	0	0	0	1	0	0	0	9039	275	10	5	178	5	LRRTM1	2	80529551	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	6454740	80529551	162669822	36	27097										
C2orf29	55571	broad.mit.edu	37	chr2	101869621	101869621	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggcaggatgagcttgaccccGaaggagctctcgagcctgct	14	12	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:101869621G>A	uc002taw.3	+	1	277	c.195G>A	c.(193-195)CCG>CCA	p.P65P		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	65					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GCTTGACCCCGAAGGAGCTCT	0.527													0	0	0	0.00308	0	7	25										A	101869621	G	A	101869621	2	1	90	1	0	0	0	0	0	0	0	1	2161	1045	37	1		1	C2orf29	2	101869621	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	21340070	101869621	141329752	37	27098										
IL18RAP	8807	broad.mit.edu	37	chr2	103063657	103063657	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acctaccagagcaaggatcaGacgcttgggggtaagtttac	12	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:103063657G>C	uc002tbx.2	+	10	1684	c.1200G>C	c.(1198-1200)CAG>CAC	p.Q400H	IL18RAP_uc010fiz.2_Missense_Mutation_p.Q258H	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	400	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						GCAAGGATCAGACGCTTGGGG	0.557													0	0	0	0.01441	0	225	180										C	103063657	G	C	103063657	3	2	90	1	0	0	0	0	1	0	0	0	7648	933	33	1	1230	1	IL18RAP	2	103063657	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1194036	103063657	140135716	38	27099										
CNTNAP5	129684	broad.mit.edu	37	chr2	125192129	125192129	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcaatcagaagttgatgagtActctcaaagatgtgatctcc	8	8	4	5			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:125192129A>T	uc002tno.2	+	5	962	c.598A>T	c.(598-600)ACT>TCT	p.T200S	CNTNAP5_uc010flu.2_Missense_Mutation_p.T200S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	200	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GTTGATGAGTACTCTCAAAGA	0.468													0	0	0	0.014323	0	22	77										T	125192129	A	T	125192129	3	4	90	1	0	0	0	0	1	0	0	0	3650	391	14	5	616	5	CNTNAP5	2	125192129	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	22128472	125192129	118007244	39	27100										
ACVR2A	92	broad.mit.edu	37	chr2	148676128	148676128	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acatgaggatatacctggccTaaaagatggccacaaacctg	9	10	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:148676128T>A	uc002twg.2	+	8	1198	c.929T>A	c.(928-930)CTA>CAA	p.L310Q	ACVR2A_uc010zbn.1_Missense_Mutation_p.L202Q|ACVR2A_uc002twh.2_Missense_Mutation_p.L310Q	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	310	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		ATACCTGGCCTAAAAGATGGC	0.378													0	0	0	0.001855	0	5	43										A	148676128	T	A	148676128	3	1	90	1	0	0	0	0	1	0	0	0	223	1522	53	5	955	5	ACVR2A	2	148676128	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	23483999	148676128	94523245	40	27101										
NEB	4703	broad.mit.edu	37	chr2	152468823	152468823	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctcaggatttctccagctctCttcactttctcgacctctac	4	16	6	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:152468823C>G	uc010fnx.2	-	74	11144	c.10953G>C	c.(10951-10953)AAG>AAC	p.K3651N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3651	Nebulin 100.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTCCAGCTCTCTTCACTTTCT	0.458													0	0	0	0.00623	0	37	21										G	152468823	C	G	152468823	3	3	90	1	0	0	0	0	1	0	0	0	10302	912	32	1	14424	1	NEB	2	152468823	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3792695	152468823	90730550	41	27102										
NR4A2	4929	broad.mit.edu	37	chr2	157182439	157182439	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccccattgttgaaagtcacGtggtctttgagacaatttac	8	10	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:157182439G>A	uc002tyz.3	-	8	2036	c.1614C>T	c.(1612-1614)CAC>CAT	p.H538H	NR4A2_uc002tyx.3_Silent_p.H475H|NR4A2_uc010zcf.1_Silent_p.H538H	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	538					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						TGAAAGTCACGTGGTCTTTGA	0.463													0	0	0	0.00632	0	28	60										A	157182439	G	A	157182439	2	1	90	1	0	0	0	0	0	0	0	1	10633	1136	40	2		2	NR4A2	2	157182439	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	4713616	157182439	86016934	42	27103										
ACVR1C	130399	broad.mit.edu	37	chr2	158406900	158406900	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtcctttgaaccaacagaggTagacctaaccaaagaaaaga	8	9	0	5			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:158406900T>C	uc002tzk.3	-	4	792	c.549A>G	c.(547-549)CTA>CTG	p.L183L	ACVR1C_uc002tzl.3_Silent_p.L103L|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Silent_p.L133L	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	183	Cytoplasmic (Potential).|GS.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						CCAACAGAGGTAGACCTAACC	0.368													0	0	0	0.01441	0	61	32										C	158406900	T	C	158406900	2	2	90	1	0	0	0	0	0	0	0	1	222	1625	57	5		5	ACVR1C	2	158406900	Silent	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	1224461	158406900	84792473	43	27104										
TANK	10010	broad.mit.edu	37	chr2	162088031	162088031	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	accttttccctcactcgattCcccgggaaaagcaatccgag	7	15	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:162088031C>A	uc002ubr.1	+	7	1228	c.1070C>A	c.(1069-1071)TCC>TAC	p.S357Y	TANK_uc002ubs.2_Missense_Mutation_p.S357Y	NM_004180	NP_004171	Q92844	TANK_HUMAN	TRAF interacting protein TANK isoform a	357						cytosol	metal ion binding|protein binding			ovary(1)	1						TCACTCGATTCCCCGGGAAAA	0.428													1	0	7.22619e-39	0.01441	8.29016e-39	55	65										A	162088031	C	A	162088031	3	1	90	1	0	0	0	0	1	0	0	0	15543	855	30	3	1125	3	TANK	2	162088031	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3681131	162088031	81111342	44	27105										
KCNH7	90134	broad.mit.edu	37	chr2	163256815	163256815	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgtctcctggaggtgcatggGtggttttgaacttcattgcc	13	8	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:163256815G>T	uc002uch.1	-	10	2503	c.2291C>A	c.(2290-2292)ACC>AAC	p.T764N		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	764	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	AGGTGCATGGGTGGTTTTGAA	0.458													1	0	5.32379e-58	0.01441	6.18353e-58	136	110										T	163256815	G	T	163256815	3	4	90	1	0	0	0	0	1	0	0	0	8037	1261	44	4	1327	4	KCNH7	2	163256815	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1168784	163256815	79942558	45	27106										
SCN1A	6323	broad.mit.edu	37	chr2	166850696	166850696	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	accacaaaatcaaaaatattCcatccaatggtaaaataata	2	8	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:166850696C>T	uc010zcz.1	-	25	4797	c.4779G>A	c.(4777-4779)TGG>TGA	p.W1593*		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1604	IV.|Helical; Name=S3 of repeat IV; (By similarity).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAAAAATATTCCATCCAATGG	0.323													0	0	0	0.001855	0	13	34										T	166850696	C	T	166850696	4	4	90	1	0	0	0	0	0	1	0	0	13914	856	30	1	1225	1	SCN1A	2	166850696	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3593881	166850696	76348677	46	27107										
LRP2	4036	broad.mit.edu	37	chr2	170063662	170063662	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aacaatatgcctaggcatgtCcactgtgactttaagaagaa	8	8	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:170063662C>G	uc002ues.2	-	39	6781	c.6568G>C	c.(6568-6570)GAC>CAC	p.D2190H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2190	LDL-receptor class B 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTAGGCATGTCCACTGTGACT	0.428													0	0	0	0.01441	0	106	95										G	170063662	C	G	170063662	3	3	90	1	0	0	0	0	1	0	0	0	8956	855	30	1	7563	1	LRP2	2	170063662	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3212966	170063662	73135711	47	27108										
MYO3B	140469	broad.mit.edu	37	chr2	171259362	171259362	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttctctctcatgcagtagtGcaggaggtggaatgaatgtg	13	7	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:171259362G>T	uc002ufy.2	+	19	2277	c.2134G>T	c.(2134-2136)GCA>TCA	p.A712S	MYO3B_uc002ufv.2_Missense_Mutation_p.A699S|MYO3B_uc010fqb.1_Missense_Mutation_p.A699S|MYO3B_uc002ufz.2_Missense_Mutation_p.A712S|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	712	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						ATGCAGTAGTGCAGGAGGTGG	0.428													1	0	4.54149e-19	0.014323	4.96642e-19	21	107										T	171259362	G	T	171259362	3	4	90	1	0	0	0	0	1	0	0	0	10077	1319	46	4	2208	4	MYO3B	2	171259362	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1195700	171259362	71940011	48	27109										
FKBP7	51661	broad.mit.edu	37	chr2	179343041	179343041	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gagccgtctttagccaggtaGccgtcataatgggcatttag	12	9	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:179343041G>T	uc002umk.2	-	1	315	c.186C>A	c.(184-186)GGC>GGA	p.G62G	FKBP7_uc002umm.2_Silent_p.G62G|FKBP7_uc002uml.2_RNA|FKBP7_uc010zff.1_Silent_p.G58G|PLEKHA3_uc002umn.2_5'Flank	NM_181342	NP_851939	Q9Y680	FKBP7_HUMAN	FK506 binding protein 7 isoform a precursor	62	PPIase FKBP-type.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TAGCCAGGTAGCCGTCATAAT	0.498													1	0	1.99505e-19	0.012213	2.18812e-19	33	108										T	179343041	G	T	179343041	2	4	90	1	0	0	0	0	0	0	0	1	5913	958	34	4		4	FKBP7	2	179343041	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	8083679	179343041	63856332	49	27110										
TTN	7273	broad.mit.edu	37	chr2	179617850	179617850	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcacatccattataacaataCctttcatttccatctcaatc	0	13	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:179617850C>A	uc010zfg.1	-	45	10584	c.10360_splice	c.e45+1	p.A3454_splice	TTN_uc010zfh.1_Splice_Site_p.E3600_splice|TTN_uc010zfi.1_Splice_Site_p.E3533_splice|TTN_uc010zfj.1_Splice_Site_p.E3408_splice|TTN_uc002umz.1_Splice_Site_p.A115_splice|TTN_uc002unb.2_Splice_Site_p.E3454_splice	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATAACAATACCTTTCATTTC	0.294													1	0	1.23904e-05	0.000602	1.28011e-05	5	12										A	179617850	C	A	179617850	5	1	90	1	0	0	0	0	0	0	1	0	16732	521	18	4	99940	4	TTN	2	179617850	Splice_Site	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	274809	179617850	63581523	50	27111										
BMPR2	659	broad.mit.edu	37	chr2	203420682	203420682	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcctttgaacaccaaaaattCaacaaaagagccccggctaa	6	12	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:203420682C>T	uc002uzf.3	+	12	3442	c.2294C>T	c.(2293-2295)TCA>TTA	p.S765L	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	765	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						ACCAAAAATTCAACAAAAGAG	0.428													0	0	0	0.00278	0	23	80										T	203420682	C	T	203420682	3	4	90	1	0	0	0	0	1	0	0	0	1471	838	29	1	2340	1	BMPR2	2	203420682	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	23802832	203420682	39778691	51	27112										
ZDBF2	57683	broad.mit.edu	37	chr2	207172029	207172029	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttataatatcatttttcattCagtgactggacgttctgaag	7	6	4	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:207172029C>T	uc002vbp.2	+	5	3027	c.2777C>T	c.(2776-2778)TCA>TTA	p.S926L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	926							nucleic acid binding|zinc ion binding			ovary(3)	3						ATTTTTCATTCAGTGACTGGA	0.318													0	0	0	0.00499	0	18	40										T	207172029	C	T	207172029	3	4	90	1	0	0	0	0	1	0	0	0	17596	838	29	1	2787	1	ZDBF2	2	207172029	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3751347	207172029	36027344	52	27113										
ERBB4	2066	broad.mit.edu	37	chr2	212285209	212285209	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tggaagtatagatgggaggtGggatgttgaaagcctgaggg	19	2	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:212285209G>A	uc002veg.1	-	25	3190	c.3092C>T	c.(3091-3093)CCA>CTA	p.P1031L	ERBB4_uc002veh.1_Missense_Mutation_p.P1031L|ERBB4_uc010zji.1_Missense_Mutation_p.P1021L|ERBB4_uc010zjj.1_Missense_Mutation_p.P1021L	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1031	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GATGGGAGGTGGGATGTTGAA	0.373										TSP Lung(8;0.080)			0	0	0	0.009096	0	4	70										A	212285209	G	A	212285209	3	1	90	1	0	0	0	0	1	0	0	0	5209	1348	47	2	850	2	ERBB4	2	212285209	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5113180	212285209	30914164	53	27114										
ATG9A	79065	broad.mit.edu	37	chr2	220089301	220089301	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gccttgaggctccattcattGagaaacagagagccaggtcc	11	11	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:220089301G>C	uc002vke.1	-	8	978	c.792C>G	c.(790-792)CTC>CTG	p.L264L	ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Silent_p.L264L	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	264	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCATTCATTGAGAAACAGAG	0.582													0	0	0	0.00499	0	15	42										C	220089301	G	C	220089301	2	2	90	1	0	0	0	0	0	0	0	1	1102	1277	45	1		1	ATG9A	2	220089301	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	7804092	220089301	23110072	54	27115										
DNPEP	23549	broad.mit.edu	37	chr2	220251131	220251131	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgcggcgagaccgacgtttCacctgagtgtaaagatggag	14	9	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:220251131C>T	uc010zlg.1	-	5	442	c.360G>A	c.(358-360)GTG>GTA	p.V120V	DNPEP_uc010zlf.1_5'Flank|DNPEP_uc002vle.2_Silent_p.V112V|DNPEP_uc002vlf.1_Silent_p.V98V|DNPEP_uc002vlh.2_Silent_p.V59V|DNPEP_uc002vli.1_Silent_p.V59V|DNPEP_uc002vlj.2_Silent_p.V102V|uc002vlk.1_5'Flank	NM_012100	NP_036232	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	102					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	ACCGACGTTTCACCTGAGTGT	0.517													0	0	0	0.00333	0	23	80										T	220251131	C	T	220251131	2	4	90	1	0	0	0	0	0	0	0	1	4679	813	29	1		1	DNPEP	2	220251131	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	161830	220251131	22948242	55	27116										
DNER	92737	broad.mit.edu	37	chr2	230377518	230377518	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccaggaaggcaaacacaggtGaaattgctcccatcttgctt	9	11	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:230377518G>A	uc002vpv.2	-	6	1275	c.1128C>T	c.(1126-1128)TTC>TTT	p.F376F	DNER_uc010zly.1_Silent_p.F104F	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	376	Extracellular (Potential).|EGF-like 4.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AAACACAGGTGAAATTGCTCC	0.398													0	0	0	0.01441	0	89	72										A	230377518	G	A	230377518	2	1	90	1	0	0	0	0	0	0	0	1	4667	1281	45	1		1	DNER	2	230377518	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10126387	230377518	12821855	56	27117										
SNED1	25992	broad.mit.edu	37	chr2	242027796	242027796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcaggaaacaaagtaagagtCagacactggagaaatcttaa	9	6	3	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr2:242027796C>G	uc002wah.1	+	31	4222	c.4222C>G	c.(4222-4224)CAG>GAG	p.Q1408E	SNED1_uc002waj.1_Missense_Mutation_p.Q434E	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	1408					cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		AAGTAAGAGTCAGACACTGGA	0.512													0	0	0	0.001168	0	5	92										G	242027796	C	G	242027796	3	3	90	1	0	0	0	0	1	0	0	0	14845	827	29	1	4344	1	SNED1	2	242027796	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	11650278	242027796	1171577	57	27118										
TTLL3	26140	broad.mit.edu	37	chr3	9862298	9862298	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cagagtttgtggatgaagctCtgtgtgcgtgcgaggagtac	16	6	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:9862298C>G	uc003btg.2	+	7	814	c.598C>G	c.(598-600)CTG>GTG	p.L200V	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Missense_Mutation_p.L167V|TTLL3_uc003btf.3_5'UTR|TTLL3_uc010hco.1_Missense_Mutation_p.L136V|TTLL3_uc003bth.3_5'UTR|TTLL3_uc011atj.1_Missense_Mutation_p.L136V|TTLL3_uc003btj.3_5'UTR|TTLL3_uc003bti.3_5'UTR	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	200	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GGATGAAGCTCTGTGTGCGTG	0.582													0	0	0	0.01441	0	66	202										G	9862298	C	G	9862298	3	3	90	1	0	0	0	0	1	0	0	0	16725	912	32	1	620	1	TTLL3	3	9862298	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		9862298	188160132	58	27119										
PPARG	5468	broad.mit.edu	37	chr3	12447409	12447409	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tttgggcggatgccacaggcCgagaaggagaagctgttggc	17	8	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:12447409C>A	uc003bwx.2	+	5	739	c.648C>A	c.(646-648)GCC>GCA	p.A216A	PPARG_uc003bwr.2_Silent_p.A188A|PPARG_uc003bws.2_Silent_p.A188A|PPARG_uc003bwu.2_Silent_p.A188A|PPARG_uc003bwv.2_Silent_p.A188A|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Silent_p.A188A|PPARG_uc003bwt.1_Silent_p.A188A|PPARG_uc003bww.1_Silent_p.A216A	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	216	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TGCCACAGGCCGAGAAGGAGA	0.517			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						1	0	2.98393e-07	0.00278	3.11729e-07	22	120										A	12447409	C	A	12447409	2	1	90	1	0	0	0	0	0	0	0	1	12299	639	23	4		4	PPARG	3	12447409	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2585111	12447409	185575021	59	27120										
FBLN2	2199	broad.mit.edu	37	chr3	13660497	13660497	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caccatcccgctgccactgcCgcagcccaatacctgcaaag	7	19	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:13660497C>T	uc011avb.1	+	7	2158	c.2033C>T	c.(2032-2034)CCG>CTG	p.P678L	FBLN2_uc011auz.1_Missense_Mutation_p.P704L|FBLN2_uc011ava.1_Missense_Mutation_p.P678L|FBLN2_uc011avc.1_Missense_Mutation_p.P678L	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	678						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			CTGCCACTGCCGCAGCCCAAT	0.622													0	0	0	0.001984	0	7	19										T	13660497	C	T	13660497	3	4	90	1	0	0	0	0	1	0	0	0	5699	652	23	2	745	2	FBLN2	3	13660497	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1213088	13660497	184361933	60	27121										
ZNF385D	79750	broad.mit.edu	37	chr3	21552450	21552450	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acagatttctgcttatttttCatggcttccagtgctttgag	8	8	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:21552450C>T	uc003cce.2	-	4	750	c.342G>A	c.(340-342)ATG>ATA	p.M114I	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	114						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GCTTATTTTTCATGGCTTCCA	0.463													0	0	0	0.01441	0	72	75										T	21552450	C	T	21552450	3	4	90	1	0	0	0	0	1	0	0	0	17875	826	29	1	865	1	ZNF385D	3	21552450	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	7891953	21552450	176469980	61	27122										
XYLB	9942	broad.mit.edu	37	chr3	38401846	38401846	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcaggactcagggtggtgttCatgtgcacaaggatgggctg	17	7	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:38401846C>G	uc003cic.2	+	3	266	c.157C>G	c.(157-159)CAT>GAT	p.H53D	XYLB_uc011ayp.1_Intron|XYLB_uc003cid.1_5'UTR	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	53					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		GGGTGGTGTTCATGTGCACAA	0.532													0	0	0	0.01441	0	93	96										G	38401846	C	G	38401846	3	3	90	1	0	0	0	0	1	0	0	0	17459	826	29	1	167	1	XYLB	3	38401846	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	16849396	38401846	159620584	62	27123										
ZNF662	389114	broad.mit.edu	37	chr3	42954704	42954704	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccctggcaggatatccatttCtaaagcctgctgggatttcc	9	12	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:42954704C>G	uc003cmi.2	+	4	515	c.163C>G	c.(163-165)CTA>GTA	p.L55V	ZNF662_uc003cmk.2_Intron|ZNF662_uc003cmj.2_Intron	NM_207404	NP_997287	Q6ZS27	ZN662_HUMAN	zinc finger protein 662 isoform 1	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.217)		ATATCCATTTCTAAAGCCTGC	0.498													0	0	0	0.004007	0	16	56										G	42954704	C	G	42954704	3	3	90	1	0	0	0	0	1	0	0	0	18068	912	32	1	360	1	ZNF662	3	42954704	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	4552858	42954704	155067726	63	27124										
CCR5	1234	broad.mit.edu	37	chr3	46415295	46415295	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	catcatctatgcctttgtcgGggagaagttcagaaactacc	9	10	3	2	rs1800943		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:46415295G>A	uc003cpo.3	+	3	1024	c.902G>A	c.(901-903)GGG>GAG	p.G301E	CCR5_uc010hjd.2_Missense_Mutation_p.G301E	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	301	Helical; Name=7; (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GCCTTTGTCGGGGAGAAGTTC	0.483													0	0	0	0.01441	0	293	290										A	46415295	G	A	46415295	3	1	90	1	0	0	0	0	1	0	0	0	2944	1232	43	2	904	2	CCR5	3	46415295	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	3460591	46415295	151607135	64	27125										
NBEAL2	23218	broad.mit.edu	37	chr3	47040469	47040469	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcggtgggtgcgctggacctGctgctggccctgctgcacgg	18	13	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:47040469G>A	uc003cqp.2	+	24	3584	c.3405G>A	c.(3403-3405)CTG>CTA	p.L1135L	NBEAL2_uc010hjm.1_Intron|NBEAL2_uc010hjn.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1135	Leu-rich.						binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CGCTGGACCTGCTGCTGGCCC	0.667											OREG0015546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	16										A	47040469	G	A	47040469	2	1	90	1	0	0	0	0	0	0	0	1	10189	1306	46	2		2	NBEAL2	3	47040469	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	625174	47040469	150981961	65	27126										
BSN	8927	broad.mit.edu	37	chr3	49692495	49692495	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcaagccaggcccagtgccaGagccaggtgccgagccccac	12	17	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:49692495G>T	uc003cxe.3	+	5	5620	c.5506G>T	c.(5506-5508)GAG>TAG	p.E1836*		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1836					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCCAGTGCCAGAGCCAGGTGC	0.622													1	0	7.11191e-15	0.013726	7.70972e-15	33	114										T	49692495	G	T	49692495	4	4	90	1	0	0	0	0	0	1	0	0	1530	943	33	3	5524	3	BSN	3	49692495	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	2652026	49692495	148329935	66	27127										
DOCK3	1795	broad.mit.edu	37	chr3	51264853	51264853	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gttccggggctcccacctgcGctttgagttcagacattgtt	11	12	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:51264853G>A	uc011bds.1	+	16	1540	c.1517G>A	c.(1516-1518)CGC>CAC	p.R506H		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	506	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCCCACCTGCGCTTTGAGTTC	0.468													0	0	0	0.01441	0	82	103										A	51264853	G	A	51264853	3	1	90	1	0	0	0	0	1	0	0	0	4688	1087	38	2	1579	2	DOCK3	3	51264853	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1572358	51264853	146757577	67	27128										
RAD54L2	23132	broad.mit.edu	37	chr3	51673632	51673632	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aatagcaagttcctacagggCgttggcttcaaccctttcca	8	12	1	0	rs139263625	byFrequency	TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:51673632C>T	uc011bdt.1	+	12	2183	c.2058C>T	c.(2056-2058)GGC>GGT	p.G686G	RAD54L2_uc003dbh.2_Silent_p.G277G|RAD54L2_uc011bdu.1_Silent_p.G380G|RAD54L2_uc003dbj.2_Silent_p.G12G	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	686						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		TCCTACAGGGCGTTGGCTTCA	0.517													0	0	0	0.006214	0	8	41										T	51673632	C	T	51673632	2	4	90	1	0	0	0	0	0	0	0	1	12994	755	27	2		2	RAD54L2	3	51673632	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	408779	51673632	146348798	68	27129										
FLNB	2317	broad.mit.edu	37	chr3	58095302	58095302	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccttctccatgtcttctctaGgtcaacatcgggcaaggtag	9	12	4	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:58095302G>A	uc003djj.2	+	15	2365	c.2200_splice	c.e15-1	p.V734_splice	FLNB_uc010hne.2_Splice_Site_p.V734_splice|FLNB_uc003djk.2_Splice_Site_p.V734_splice|FLNB_uc010hnf.2_Splice_Site_p.V734_splice|FLNB_uc003djl.2_Splice_Site_p.V565_splice|FLNB_uc003djm.2_Splice_Site_p.V565_splice	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2						actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GTCTTCTCTAGGTCAACATCG	0.458													0	0	0	0.01441	0	74	90										A	58095302	G	A	58095302	5	1	90	1	0	0	0	0	0	0	1	0	5934	1014	35	2	2257	2	FLNB	3	58095302	Splice_Site	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	6421670	58095302	139927128	69	27130										
ROBO2	6092	broad.mit.edu	37	chr3	77637928	77637928	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcaatgaagttgtcattactGaaaacaataacagcataact	6	7	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:77637928G>C	uc003dpy.3	+	17	3170	c.2527G>C	c.(2527-2529)GAA>CAA	p.E843Q	ROBO2_uc003dpz.2_Missense_Mutation_p.E847Q|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.E847Q|ROBO2_uc003dqa.2_5'UTR	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	843	Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGTCATTACTGAAAACAATAA	0.373													0	0	0	0.009718	0	45	57										C	77637928	G	C	77637928	3	2	90	1	0	0	0	0	1	0	0	0	13514	1291	45	1	2595	1	ROBO2	3	77637928	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	19542626	77637928	120384502	70	27131										
IMPG2	50939	broad.mit.edu	37	chr3	100962599	100962599	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cataactaccaaccttgccaTtttgctcttggacttgctca	5	13	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:100962599T>C	uc003duq.1	-	13	2779	c.2576A>G	c.(2575-2577)AAT>AGT	p.N859S	IMPG2_uc011bhe.1_Missense_Mutation_p.N722S	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	859	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AACCTTGCCATTTTGCTCTTG	0.448													0	0	0	0.01441	0	51	90										C	100962599	T	C	100962599	3	2	90	1	0	0	0	0	1	0	0	0	7729	1493	52	5	1177	5	IMPG2	3	100962599	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	23324671	100962599	97059831	71	27132										
BBX	56987	broad.mit.edu	37	chr3	107435578	107435578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	attttgcaaacgccatcgctCtcttgtacgtcaggaacacc	7	13	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:107435578C>T	uc010hpr.2	+	5	614	c.287C>T	c.(286-288)TCT>TTT	p.S96F	BBX_uc003dwk.3_Missense_Mutation_p.S96F|BBX_uc003dwl.3_Missense_Mutation_p.S96F|BBX_uc010hps.1_Missense_Mutation_p.S117F|BBX_uc003dwm.3_Missense_Mutation_p.S96F	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	96	HMG box.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			CGCCATCGCTCTCTTGTACGT	0.463													0	0	0	0.01441	0	111	68										T	107435578	C	T	107435578	3	4	90	1	0	0	0	0	1	0	0	0	1343	913	32	1	293	1	BBX	3	107435578	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	6472979	107435578	90586852	72	27133										
PHLDB2	90102	broad.mit.edu	37	chr3	111664202	111664202	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttaaccccaatactttaaaaGaggtaagctatgattttaca	5	7	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:111664202G>C	uc010hqa.2	+	9	2896	c.2485G>C	c.(2485-2487)GAG>CAG	p.E829Q	PHLDB2_uc003dyc.2_Missense_Mutation_p.E813Q|PHLDB2_uc003dyd.2_Missense_Mutation_p.E786Q|PHLDB2_uc003dyg.2_Missense_Mutation_p.E829Q|PHLDB2_uc003dyh.2_Missense_Mutation_p.E786Q|PHLDB2_uc003dyi.2_Missense_Mutation_p.E415Q	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	829						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TACTTTAAAAGAGGTAAGCTA	0.348													0	0	0	0.007291	0	27	20										C	111664202	G	C	111664202	3	2	90	1	0	0	0	0	1	0	0	0	11852	943	33	1	2600	1	PHLDB2	3	111664202	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	4228624	111664202	86358228	73	27134										
GTPBP8	29083	broad.mit.edu	37	chr3	112710056	112710056	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caagaccttcacctgcgtatCtttgacccaagcccggagga	9	14	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:112710056C>T	uc003dzn.2	+	1	257	c.210C>T	c.(208-210)ATC>ATT	p.I70I	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Silent_p.I70I	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	70					barrier septum formation		GTP binding				0						ACCTGCGTATCTTTGACCCAA	0.622													0	0	0	0.004656	0	25	48										T	112710056	C	T	112710056	2	4	90	1	0	0	0	0	0	0	0	1	6884	903	32	1		1	GTPBP8	3	112710056	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1045854	112710056	85312374	74	27135										
PLA1A	51365	broad.mit.edu	37	chr3	119344030	119344030	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gaaacaaggacaccaacatcGaggttaccttccttagcagt	8	11	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:119344030G>A	uc003ecu.2	+	9	1111	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	PLA1A_uc003ecv.2_Missense_Mutation_p.E342K|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Missense_Mutation_p.E185K	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	358					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CACCAACATCGAGGTTACCTT	0.448													0	0	0	0.01441	0	51	27										A	119344030	G	A	119344030	3	1	90	1	0	0	0	0	1	0	0	0	11988	1059	37	1	1106	1	PLA1A	3	119344030	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	6633974	119344030	78678400	75	27136										
C3orf15	89876	broad.mit.edu	37	chr3	119456222	119456222	+	Missense_Mutation	SNP	G	G	C													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cattatttcaggcactgttgGataagaagaataaagttctt							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:119456222G>C	uc003ede.3	+	11	1431	c.1354G>C	c.(1354-1356)GAT>CAT	p.D452H	C3orf15_uc010hqy.1_Missense_Mutation_p.D452H|C3orf15_uc010hqz.2_Missense_Mutation_p.D390H|C3orf15_uc011bjd.1_Missense_Mutation_p.D326H|C3orf15_uc011bje.1_Missense_Mutation_p.D432H|C3orf15_uc010hra.1_Missense_Mutation_p.D213H	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	Error:Variant_position_missing_in_Q7Z4T9_after_alignment						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GGCACTGTTGGATAAGAAGAA	0.279													0	0	0	0.010504	0	21	68										C	119456222	G	C	119456222	3	2	90	1	0	0	0	0	1	0	0	0	2209	1174	41	1	1396	1	C3orf15	3	119456222	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	112192	119456222	78566208	76	27137	133	2								
C3orf15	89876	broad.mit.edu	37	chr3	119456227	119456227	+	Silent	SNP	G	G	A													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tttcaggcactgttggataaGaagaataaagttcttgaagt							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:119456227G>A	uc003ede.3	+	11	1436	c.1359G>A	c.(1357-1359)AAG>AAA	p.K453K	C3orf15_uc010hqy.1_Silent_p.K453K|C3orf15_uc010hqz.2_Silent_p.K391K|C3orf15_uc011bjd.1_Silent_p.K327K|C3orf15_uc011bje.1_Silent_p.K433K|C3orf15_uc010hra.1_Silent_p.K214K	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	Error:Variant_position_missing_in_Q7Z4T9_after_alignment						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		TGTTGGATAAGAAGAATAAAG	0.294													0	0	0	0.008871	0	20	69										A	119456227	G	A	119456227	2	1	90	1	0	0	0	0	0	0	0	1	2209	933	33	1		1	C3orf15	3	119456227	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5	119456227	78566203	77	27138	133	2								
IQCJ	654502	broad.mit.edu	37	chr3	158983102	158983102	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggaaggaaggtgattcttctCtaccttgaccagcttgccag	11	10	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:158983102C>T	uc003fcp.1	+	5	495	c.390C>T	c.(388-390)CTC>CTT	p.L130L	SCHIP1_uc003fcq.1_Intron|SCHIP1_uc003fcr.1_Intron|IQCJ_uc010hvy.1_Silent_p.L103L	NM_001042705	NP_001036170	Q1A5X6	IQCJ_HUMAN	IQ motif containing J isoform CaMBPv1	130											0			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			TGATTCTTCTCTACCTTGACC	0.512													0	0	0	0.01441	0	74	58										T	158983102	C	T	158983102	2	4	90	1	0	0	0	0	0	0	0	1	7812	900	32	1		1	IQCJ	3	158983102	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	39526875	158983102	39039328	78	27139										
IL1RAP	3556	broad.mit.edu	37	chr3	190366273	190366273	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cctctcggggcaacatcaacGtcattttagtacagtacaaa	7	11	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:190366273G>C	uc003fsm.1	+	12	1698	c.1492G>C	c.(1492-1494)GTC>CTC	p.V498L	IL1RAP_uc010hzg.1_Missense_Mutation_p.V498L|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Missense_Mutation_p.V498L|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Intron	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	498	Cytoplasmic (Potential).|TIR.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		CAACATCAACGTCATTTTAGT	0.502													0	0	0	0.01441	0	59	139										C	190366273	G	C	190366273	3	2	90	1	0	0	0	0	1	0	0	0	7660	1145	40	4	1550	4	IL1RAP	3	190366273	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	31383171	190366273	7656157	79	27140										
MFI2	4241	broad.mit.edu	37	chr3	196753550	196753550	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccttgatcgtacacttcgccCaccaccggcttcaggccgtg	9	17	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr3:196753550C>T	uc003fxk.3	-	3	398	c.285G>A	c.(283-285)GTG>GTA	p.V95V	MFI2_uc003fxl.3_Silent_p.V95V|MFI2_uc011bua.1_Silent_p.V95V	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	95	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		ACACTTCGCCCACCACCGGCT	0.622													0	0	0	0.004007	0	16	77										T	196753550	C	T	196753550	2	4	90	1	0	0	0	0	0	0	0	1	9522	581	21	2		2	MFI2	3	196753550	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	6387277	196753550	1268880	80	27141										
ZNF721	170960	broad.mit.edu	37	chr4	436965	436965	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tttcttatattcattcaggtTtgtggacaatccaaaggctc	7	8	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:436965T>C	uc003gag.2	-	3	1982	c.1291A>G	c.(1291-1293)AAC>GAC	p.N431D	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.N463D|ZNF721_uc010ibe.2_Missense_Mutation_p.N419D	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	431						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TCATTCAGGTTTGTGGACAAT	0.373													0	0	0	0.001984	0	6	44										C	436965	T	C	436965	3	2	90	1	0	0	0	0	1	0	0	0	18119	1841	64	5	1484	5	ZNF721	4	436965	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08		436965	190717311	81	27142										
FGFR3	2261	broad.mit.edu	37	chr4	1803738	1803738	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcccggacggcacaccctacGttaccgtgctcaaggtgggc	13	15	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:1803738G>A	uc003gdr.3	+	7	1172	c.916G>A	c.(916-918)GTT>ATT	p.V306I	FGFR3_uc003gdu.2_Missense_Mutation_p.V306I|FGFR3_uc003gds.3_Missense_Mutation_p.V306I|FGFR3_uc003gdq.3_Missense_Mutation_p.V306I|FGFR3_uc010icb.1_Intron|FGFR3_uc003gdt.1_Intron	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	306	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CACACCCTACGTTACCGTGCT	0.667		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.000602	0	5	10										A	1803738	G	A	1803738	3	1	90	1	0	0	0	0	1	0	0	0	5867	1145	40	2	938	2	FGFR3	4	1803738	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1366773	1803738	189350538	82	27143										
ATP10D	57205	broad.mit.edu	37	chr4	47538788	47538788	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcaaagtgatgtggatttctAcaatgaaaaaatggattcta	8	4	3	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:47538788A>G	uc003gxk.1	+	9	1393	c.1229A>G	c.(1228-1230)TAC>TGC	p.Y410C	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Missense_Mutation_p.Y395C	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	410	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GTGGATTTCTACAATGAAAAA	0.398													0	0	0	0.00245	0	14	16										G	47538788	A	G	47538788	3	3	90	1	0	0	0	0	1	0	0	0	1118	391	14	5	1259	5	ATP10D	4	47538788	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	45735050	47538788	143615488	83	27144										
ATP10D	57205	broad.mit.edu	37	chr4	47574247	47574247	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcaggtcaagaaggcatgcaGgtgagtggatattgtgcacc	14	7	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:47574247G>A	uc003gxk.1	+	17	3404	c.3240G>A	c.(3238-3240)CAG>CAA	p.Q1080Q	ATP10D_uc003gxl.1_Silent_p.Q328Q	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1080	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						AAGGCATGCAGGTGAGTGGAT	0.498													0	0	0	0.008361	0	29	34										A	47574247	G	A	47574247	2	1	90	1	0	0	0	0	0	0	0	1	1118	1014	35	2		2	ATP10D	4	47574247	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	35459	47574247	143580029	84	27145										
GSX2	170825	broad.mit.edu	37	chr4	54968033	54968033	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	actacgcgcgctccgaggatGaggactccctgtcgccggcc	13	16	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:54968033G>A	uc010igp.1	+	2	1123	c.859G>A	c.(859-861)GAG>AAG	p.E287K	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	287						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			CTCCGAGGATGAGGACTCCCT	0.647													0	0	0	0.00632	0	29	20										A	54968033	G	A	54968033	3	1	90	1	0	0	0	0	1	0	0	0	6850	1291	45	1	865	1	GSX2	4	54968033	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	7393786	54968033	136186243	85	27146										
REST	5978	broad.mit.edu	37	chr4	57777573	57777573	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtatcatttgcacatacacaAcagtgagcgagtatcactgg	9	9	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:57777573A>G	uc003hch.2	+	2	1116	c.769A>G	c.(769-771)ACA>GCA	p.T257A	REST_uc003hci.2_Missense_Mutation_p.T257A|REST_uc003hcj.1_Missense_Mutation_p.T257A|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	257	C2H2-type 3.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					CACATACACAACAGTGAGCGA	0.383													0	0	0	0.010771	0	45	40										G	57777573	A	G	57777573	3	3	90	1	0	0	0	0	1	0	0	0	13234	43	2	5	771	5	REST	4	57777573	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	2809540	57777573	133376703	86	27147										
LPHN3	23284	broad.mit.edu	37	chr4	62800707	62800707	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctggctgataaccttttgaaGactgacattgtcagggagaa	11	7	1	5			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:62800707G>A	uc010ihh.2	+	11	2231	c.2058G>A	c.(2056-2058)AAG>AAA	p.K686K	LPHN3_uc003hcq.3_Silent_p.K686K|LPHN3_uc003hct.2_Silent_p.K79K|LPHN3_uc003hcs.1_Silent_p.K502K	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	673	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ACCTTTTGAAGACTGACATTG	0.438													0	0	0	0.00499	0	15	24										A	62800707	G	A	62800707	2	1	90	1	0	0	0	0	0	0	0	1	8917	933	33	1		1	LPHN3	4	62800707	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5023134	62800707	128353569	87	27148										
EPHA5	2044	broad.mit.edu	37	chr4	66356360	66356360	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttccaccagtgtcagcaggCggaatccattccagaaagac	9	13	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:66356360C>A	uc003hcy.2	-	5	1330	c.1137G>T	c.(1135-1137)CCG>CCT	p.P379P	EPHA5_uc003hcx.2_Silent_p.P310P|EPHA5_uc003hcz.2_Silent_p.P379P|EPHA5_uc011cah.1_Silent_p.P379P|EPHA5_uc011cai.1_Silent_p.P379P|EPHA5_uc003hda.2_Silent_p.P379P	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	379	Fibronectin type-III 1.|Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TGTCAGCAGGCGGAATCCATT	0.458										TSP Lung(17;0.13)			1	0	0.000274275	0.004482	0.00028027	9	47										A	66356360	C	A	66356360	2	1	90	1	0	0	0	0	0	0	0	1	5170	755	27	4		4	EPHA5	4	66356360	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3555653	66356360	124797916	88	27149										
USO1	8615	broad.mit.edu	37	chr4	76721825	76721825	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggcaaagagaatttcatagaGaaactaggatttattagcaa	9	4	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:76721825G>C	uc003hiu.2	+	15	1912	c.1737G>C	c.(1735-1737)GAG>GAC	p.E579D	USO1_uc003hiv.2_Missense_Mutation_p.E421D|USO1_uc003hiw.2_Missense_Mutation_p.E414D	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	579	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATTTCATAGAGAAACTAGGAT	0.348													0	0	0	0.005524	0	38	25										C	76721825	G	C	76721825	3	2	90	1	0	0	0	0	1	0	0	0	17036	933	33	1	1640	1	USO1	4	76721825	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10365465	76721825	114432451	89	27150										
ANKRD56	345079	broad.mit.edu	37	chr4	77817830	77817830	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acaaagtcatccagatcttgGagggacagctgacaacgaat	10	9	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:77817830G>T	uc003hki.2	-	1	1173	c.1173C>A	c.(1171-1173)CTC>CTA	p.L391L		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	391											0						CCAGATCTTGGAGGGACAGCT	0.577													1	0	9.78306e-22	0.009535	1.08572e-21	30	113										T	77817830	G	T	77817830	2	4	90	1	0	0	0	0	0	0	0	1	682	1161	41	3		3	ANKRD56	4	77817830	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1096005	77817830	113336446	90	27151										
DSPP	1834	broad.mit.edu	37	chr4	88533799	88533799	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agccacaaacagaagcaacaCtaatggaaatactgataaga	7	8	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:88533799C>G	uc003hqu.2	+	4	581	c.461C>G	c.(460-462)ACT>AGT	p.T154S		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	154					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AGAAGCAACACTAATGGAAAT	0.438													0	0	0	0.010504	0	22	31										G	88533799	C	G	88533799	3	3	90	1	0	0	0	0	1	0	0	0	4782	565	20	4	471	4	DSPP	4	88533799	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	10715969	88533799	102620477	91	27152										
CENPE	1062	broad.mit.edu	37	chr4	104044225	104044225	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agcacttctttcctcaaactCtgttgattcattcattatgg	5	10	5	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:104044225C>G	uc003hxb.1	-	43	7036	c.6946G>C	c.(6946-6948)GAG>CAG	p.E2316Q	CENPE_uc003hxc.1_Missense_Mutation_p.E2195Q	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	2316	Kinetochore-binding domain.|Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TCCTCAAACTCTGTTGATTCA	0.264													0	0	0	0.00623	0	38	36										G	104044225	C	G	104044225	3	3	90	1	0	0	0	0	1	0	0	0	3230	922	32	1	1187	1	CENPE	4	104044225	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	15510426	104044225	87110051	92	27153										
PDE5A	8654	broad.mit.edu	37	chr4	120517758	120517758	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttggtcaacttctgcattgaAccgaggatcctagtatggaa	10	8	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:120517758A>C	uc003idh.2	-	3	906	c.751T>G	c.(751-753)TTC>GTC	p.F251V	PDE5A_uc003idf.2_Missense_Mutation_p.F209V|PDE5A_uc003idg.2_Missense_Mutation_p.F199V	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	251	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	TCTGCATTGAACCGAGGATCC	0.328													0	0	0	0.00245	0	14	29										C	120517758	A	C	120517758	3	2	90	1	0	0	0	0	1	0	0	0	11644	43	2	5	1952	5	PDE5A	4	120517758	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	16473533	120517758	70636518	93	27154										
OTUD4	54726	broad.mit.edu	37	chr4	146058794	146058794	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttcctgcttccataagtttGattatagaactgcttggatc	7	9	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:146058794G>A	uc003ika.3	-	21	3076	c.2938C>T	c.(2938-2940)CAA>TAA	p.Q980*	OTUD4_uc003ijz.3_Nonsense_Mutation_p.Q979*	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	1044							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CCATAAGTTTGATTATAGAAC	0.408													0	0	0	0.01441	0	73	131										A	146058794	G	A	146058794	4	1	90	1	0	0	0	0	0	1	0	0	11314	1299	45	1	215	1	OTUD4	4	146058794	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	25541036	146058794	45095482	94	27155										
ETFDH	2110	broad.mit.edu	37	chr4	159627494	159627494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttttactggatattgagagGaatggagccgtggactctga	13	6	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:159627494G>A	uc003iqb.2	+	11	1771	c.1439G>A	c.(1438-1440)GGA>GAA	p.G480E	ETFDH_uc011cjg.1_Missense_Mutation_p.G433E|ETFDH_uc010iqr.2_Missense_Mutation_p.G77E|ETFDH_uc011cjh.1_Missense_Mutation_p.G419E|ETFDH_uc010iqs.2_Missense_Mutation_p.G402E	NM_004453	NP_004444	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	480					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		ATATTGAGAGGAATGGAGCCG	0.378													0	0	0	0.014323	0	22	30										A	159627494	G	A	159627494	3	1	90	1	0	0	0	0	1	0	0	0	5271	1174	41	1	1481	1	ETFDH	4	159627494	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	13568700	159627494	31526782	95	27156										
GLRA3	8001	broad.mit.edu	37	chr4	175749928	175749928	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttcccagaagtaaaatcccGaaactaatgtccgaaagtgt	7	10	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr4:175749928G>A	uc003ity.1	-	1	538	c.35C>T	c.(34-36)TCG>TTG	p.S12L	GLRA3_uc003itz.1_Missense_Mutation_p.S12L|uc003iua.1_5'Flank|uc003iub.1_5'Flank	NM_006529	NP_006520	O75311	GLRA3_HUMAN	glycine receptor, alpha 3 isoform a	12					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(3)	3		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GTAAAATCCCGAAACTAATGT	0.458													0	0	0	0.010504	0	21	29										A	175749928	G	A	175749928	3	1	90	1	0	0	0	0	1	0	0	0	6456	1059	37	1	1399	1	GLRA3	4	175749928	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	16122434	175749928	15404348	96	27157										
C5orf42	65250	broad.mit.edu	37	chr5	37183592	37183592	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccctggaataaggtaggtctCtttcaagaatgtaactcaaa	8	8	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:37183592C>G	uc011cpa.1	-	26	4922	c.4691G>C	c.(4690-4692)AGA>ACA	p.R1564T	C5orf42_uc011coy.1_Missense_Mutation_p.R65T|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.R639T|C5orf42_uc011cpb.1_Missense_Mutation_p.R445T	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1564										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AGGTAGGTCTCTTTCAAGAAT	0.323													0	0	0	0.008871	0	20	54										G	37183592	C	G	37183592	3	3	90	1	0	0	0	0	1	0	0	0	2301	913	32	1	5010	1	C5orf42	5	37183592	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		37183592	143731668	97	27158										
SNX18	112574	broad.mit.edu	37	chr5	53815261	53815261	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtgggcctgaaccaggctatCgccttcaccggagatgccta	12	13	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:53815261C>T	uc003jpj.3	+	1	1669	c.1479C>T	c.(1477-1479)ATC>ATT	p.I493I	SNX18_uc011cqg.1_Silent_p.I493I|SNX18_uc003jpi.3_Silent_p.I493I	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	493	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				ACCAGGCTATCGCCTTCACCG	0.607													0	0	0	0.013726	0	34	56										T	53815261	C	T	53815261	2	4	90	1	0	0	0	0	0	0	0	1	14889	874	31	1		1	SNX18	5	53815261	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	16631669	53815261	127099999	98	27159										
ADAMTS6	11174	broad.mit.edu	37	chr5	64629868	64629868	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aaaaaaccaaaaaaaacttaCccagtgttccacagggctta	5	10	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:64629868C>A	uc003jtp.2	-	8	1931	c.1117_splice	c.e8+1	p.G373_splice	ADAMTS6_uc003jto.2_Splice_Site|ADAMTS6_uc003jtq.2_Splice_Site|ADAMTS6_uc003jtr.1_Splice_Site	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		aaaaaaCTTACCCAGTGTTCC	0.244													1	0	0.00198382	0.001984	0.00202166	6	12										A	64629868	C	A	64629868	5	1	90	1	0	0	0	0	0	0	1	0	270	521	18	4	2307	4	ADAMTS6	5	64629868	Splice_Site	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	10814607	64629868	116285392	99	27160										
C5orf44	80006	broad.mit.edu	37	chr5	64954221	64954221	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gaagtatttctggaagcccaGattcagaatatgacaacctc	8	9	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:64954221G>C	uc003jtz.3	+	9	921	c.591G>C	c.(589-591)CAG>CAC	p.Q197H	C5orf44_uc003jua.3_Missense_Mutation_p.Q197H|C5orf44_uc003juc.3_Missense_Mutation_p.Q191H|C5orf44_uc010iwv.2_Missense_Mutation_p.Q191H	NM_024941	NP_079217	A5PLN9	CE044_HUMAN	hypothetical protein LOC80006 isoform 2	197										ovary(1)	1						TGGAAGCCCAGATTCAGAATA	0.353													0	0	0	0.001984	0	7	4										C	64954221	G	C	64954221	3	2	90	1	0	0	0	0	1	0	0	0	2303	933	33	1	625	1	C5orf44	5	64954221	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	324353	64954221	115961039	100	27161										
TNPO1	3842	broad.mit.edu	37	chr5	72192882	72192882	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tctttttgggatgatctctaGgtatagagatgcagccttat	10	6	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:72192882G>C	uc003kck.3	+	20	2390	c.2243_splice	c.e20-1	p.G748_splice	TNPO1_uc011csj.1_Splice_Site_p.G698_splice|TNPO1_uc003kch.2_Splice_Site_p.G740_splice|TNPO1_uc003kci.3_Splice_Site_p.G740_splice|TNPO1_uc003kcg.3_Splice_Site_p.G740_splice	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1						interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		ATGATCTCTAGGTATAGAGAT	0.343													0	0	0	0.00333	0	25	23										C	72192882	G	C	72192882	5	2	90	1	0	0	0	0	0	0	1	0	16332	1014	35	4	2320	4	TNPO1	5	72192882	Splice_Site	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	7238661	72192882	108722378	101	27162										
GPR98	84059	broad.mit.edu	37	chr5	90055402	90055402	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtatttggatttgaagaaaaGactgtaagttaaacatatca	8	3	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:90055402G>A	uc003kju.2	+	58	12213	c.12117G>A	c.(12115-12117)AAG>AAA	p.K4039K	GPR98_uc003kjt.2_Silent_p.K1745K|GPR98_uc003kjv.2_Silent_p.K1639K	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4039	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGAAGAAAAGACTGTAAGTT	0.373													0	0	0	0.009096	0	4	8										A	90055402	G	A	90055402	2	1	90	1	0	0	0	0	0	0	0	1	6721	933	33	1		1	GPR98	5	90055402	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	17862520	90055402	90859858	102	27163										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139889343	139889343	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttcctcaagagatactgcttTaacaatagcagcagacaaag	7	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:139889343T>C	uc003lfs.1	+	21	4011	c.3887T>C	c.(3886-3888)TTA>TCA	p.L1296S	ANKHD1_uc003lfq.1_Missense_Mutation_p.L1315S|ANKHD1_uc003lfr.2_Missense_Mutation_p.L1296S|ANKHD1_uc003lft.1_Missense_Mutation_p.L507S|ANKHD1_uc003lfu.1_Missense_Mutation_p.L776S|ANKHD1_uc003lfv.1_Missense_Mutation_p.L373S|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.L35S|ANKHD1_uc003lfw.2_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1296						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATACTGCTTTAACAATAGCA	0.408													0	0	0	0.005443	0	27	26										C	139889343	T	C	139889343	3	2	90	1	0	0	0	0	1	0	0	0	629	1764	61	5	3969	5	ANKHD1-EIF4EBP3	5	139889343	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	49833941	139889343	41025917	103	27164										
PCDHB3	56132	broad.mit.edu	37	chr5	140481673	140481673	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agcgccacagacagagactcAggcaccaacgcccaggtaac	10	15	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:140481673A>G	uc003lio.2	+	1	1440	c.1440A>G	c.(1438-1440)TCA>TCG	p.S480S	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	480	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGAGACTCAGGCACCAACG	0.647													0	0	0	0.01441	0	69	105										G	140481673	A	G	140481673	2	3	90	1	0	0	0	0	0	0	0	1	11543	175	7	5		5	PCDHB3	5	140481673	Silent	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	592330	140481673	40433587	104	27165										
PCDHB5	26167	broad.mit.edu	37	chr5	140516673	140516673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgcgcgtgctggtgctggacGccaacgacaactcgcccttc	12	15	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:140516673G>A	uc003liq.2	+	1	1874	c.1657G>A	c.(1657-1659)GCC>ACC	p.A553T		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	553	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGCTGGACGCCAACGACAA	0.716													0	0	0	0.00278	0	23	56										A	140516673	G	A	140516673	3	1	90	1	0	0	0	0	1	0	0	0	11545	1087	38	2	1659	2	PCDHB5	5	140516673	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	35000	140516673	40398587	105	27166										
KIAA0141	9812	broad.mit.edu	37	chr5	141309811	141309811	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	attcagcagctcttccagctCagtgtttccatcgctttcaa	6	13	4	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:141309811C>T	uc003lls.2	+	7	848	c.726C>T	c.(724-726)CTC>CTT	p.L242L	KIAA0141_uc003llt.2_Silent_p.L242L	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor	242	TPR 1.				apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCCAGCTCAGTGTTTCCA	0.473													0	0	0	0.001855	0	11	24										T	141309811	C	T	141309811	2	4	90	1	0	0	0	0	0	0	0	1	8156	813	29	1		1	KIAA0141	5	141309811	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	793138	141309811	39605449	106	27167										
ADRB2	154	broad.mit.edu	37	chr5	148207103	148207103	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tccagaagattgacaaatctGagggccgcttccatgtccag	10	11	1	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:148207103G>C	uc003lpr.1	+	1	948	c.709G>C	c.(709-711)GAG>CAG	p.E237Q	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	237	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	TGACAAATCTGAGGGCCGCTT	0.547													0	0	0	0.001168	0	6	100										C	148207103	G	C	148207103	3	2	90	1	0	0	0	0	1	0	0	0	341	1291	45	1	711	1	ADRB2	5	148207103	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	6897292	148207103	32708157	107	27168										
GABRG2	2566	broad.mit.edu	37	chr5	161580368	161580368	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tattgggtctcctacctctaCctgtgaggaggtatgggttt	12	8	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:161580368C>A	uc003lyz.3	+	9	1756	c.1398C>A	c.(1396-1398)TAC>TAA	p.Y466*	GABRG2_uc010jjc.2_Nonsense_Mutation_p.Y514*|GABRG2_uc003lyy.3_Nonsense_Mutation_p.Y474*|GABRG2_uc011dej.1_Nonsense_Mutation_p.Y371*	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	466	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCTACCTCTACCTGTGAGGAG	0.443													1	0	1.07363e-35	0.01441	1.2242e-35	74	114										A	161580368	C	A	161580368	4	1	90	1	0	0	0	0	0	1	0	0	6172	518	18	4	1584	4	GABRG2	5	161580368	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	13373265	161580368	19334892	108	27169										
CLK4	57396	broad.mit.edu	37	chr5	178050303	178050303	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tggtttacaatgcctgttctCttgtgtgctactatgagatc	9	8	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr5:178050303C>T	uc003mjf.1	-	2	223	c.115G>A	c.(115-117)GAG>AAG	p.E39K	CLK4_uc003mjg.1_5'UTR|CLK4_uc010jku.1_5'UTR|CLK4_uc003mjh.1_5'UTR|CLK4_uc010jkv.1_RNA|CLK4_uc011dgg.1_Missense_Mutation_p.E39K|CLK4_uc011dgh.1_5'UTR|CLK4_uc011dgi.1_Missense_Mutation_p.E39K|CLK4_uc011dgj.1_Missense_Mutation_p.E39K|CLK4_uc003mji.2_Missense_Mutation_p.E39K|CLK4_uc010jkw.1_Missense_Mutation_p.E39K	NM_020666	NP_065717	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	39						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		TGCCTGTTCTCTTGTGTGCTA	0.388													0	0	0	0.01441	0	55	53										T	178050303	C	T	178050303	3	4	90	1	0	0	0	0	1	0	0	0	3539	922	32	1	1378	1	CLK4	5	178050303	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	16469935	178050303	2864957	109	27170										
GMDS	2762	broad.mit.edu	37	chr6	1624454	1624454	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cacgtcggcgtgcaccatctCcctcaccagctcctgcaaca	7	19	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:1624454C>T	uc003mtq.2	-	11	1259	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	357					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TGCACCATCTCCCTCACCAGC	0.677													0	0	0	0.007413	0	17	15										T	1624454	C	T	1624454	3	4	90	1	0	0	0	0	1	0	0	0	6486	864	30	1	53	1	GMDS	6	1624454	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		1624454	169490613	110	27171										
HIST1H2BI	8346	broad.mit.edu	37	chr6	26273579	26273579	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcaccaagtacaccagctccAagtaaactagttacctgggt	7	12	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:26273579A>T	uc003nhk.2	+	1	376	c.376A>T	c.(376-378)AAG>TAG	p.K126*	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	126					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CACCAGCTCCAAGTAAACTAG	0.537													0	0	0	0.004656	0	27	31										T	26273579	A	T	26273579	4	4	90	1	0	0	0	0	0	1	0	0	7148	131	5	5	378	5	HIST1H2BI	6	26273579	Nonsense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	24649125	26273579	144841488	111	27172										
LY6G6F	259215	broad.mit.edu	37	chr6	31675751	31675751	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tctgtgacctggcaggaaggGaagggtcccgtgaggggccg	19	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:31675751G>A	uc003nwa.1	+	3	486	c.486G>A	c.(484-486)GGG>GGA	p.G162G	BAT5_uc011dnz.1_Intron|LY6G6F_uc003nwb.1_Silent_p.G162G	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	162	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						GGCAGGAAGGGAAGGGTCCCG	0.627													0	0	0	0.01441	0	51	79										A	31675751	G	A	31675751	2	1	90	1	0	0	0	0	0	0	0	1	9096	1161	41	1		1	LY6G6F	6	31675751	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5402172	31675751	139439316	112	27173										
PSMB8	5696	broad.mit.edu	37	chr6	32809989	32809989	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cacatcatgttggacagcagCttggaggctgccgacactga	12	11	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:32809989C>A	uc003oce.2	-	4	502	c.459G>T	c.(457-459)AAG>AAT	p.K153N	PSMB8_uc003ocf.2_Missense_Mutation_p.K149N|PSMB8_uc011dqh.1_3'UTR	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	153					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						TGGACAGCAGCTTGGAGGCTG	0.522													1	0	2.56175e-15	0.01441	2.78515e-15	48	47										A	32809989	C	A	32809989	3	1	90	1	0	0	0	0	1	0	0	0	12683	796	28	4	383	4	PSMB8	6	32809989	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1134238	32809989	138305078	113	27174										
ZBTB9	221504	broad.mit.edu	37	chr6	33424237	33424237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tccgagtccatgcctgttttCtccgccaccgggacctatgc	9	16	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:33424237C>G	uc003oeq.2	+	2	1628	c.1360C>G	c.(1360-1362)CTC>GTC	p.L454V		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	454	C2H2-type 2; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCCTGTTTTCTCCGCCACCG	0.572													0	0	0	0.01441	0	65	54										G	33424237	C	G	33424237	3	3	90	1	0	0	0	0	1	0	0	0	17555	913	32	1	1362	1	ZBTB9	6	33424237	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	614248	33424237	137690830	114	27175										
DAAM2	23500	broad.mit.edu	37	chr6	39847178	39847178	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gacccctaccccagcagtgaCgtcccactcaggaaaaagcg	9	16	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:39847178C>T	uc003oow.2	+	14	1926	c.1770C>T	c.(1768-1770)GAC>GAT	p.D590D	DAAM2_uc010jxc.2_Silent_p.D590D|DAAM2_uc003oox.2_Silent_p.D590D	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	590	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CCAGCAGTGACGTCCCACTCA	0.597													0	0	0	0.010818	0	32	39										T	39847178	C	T	39847178	2	4	90	1	0	0	0	0	0	0	0	1	4216	535	19	2		2	DAAM2	6	39847178	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	6422941	39847178	131267889	115	27176										
LRFN2	57497	broad.mit.edu	37	chr6	40400554	40400557	+	Frame_Shift_Del	DEL	TCGA	TCGA	-													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gatgcagggagcggaggctcTcgaggtccagaaaggaaaag							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:40400554_40400557delTCGA	uc003oph.1	-	2	761_764	c.296_299delTCGA	c.(295-300)CTCGAGfs	p.L99fs		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	99_100	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCGGAGGCTCTCGAGGTCCAGAAA	0.603																		14	37	---	---								-	40400557	TCGA	-	40400554	7	5	90	1	0	1	0	1	0	0	0	0	8938	1551	54	0	2078	0	LRFN2	6	40400554	Frame_Shift_Del	DEL	TCGA	TCGA-FJ-A3ZF-01A-11D-A23M-08	553376	40400554	130714513	116	27177										
GNMT	27232	broad.mit.edu	37	chr6	42930028	42930028	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gacaagatgctgaagtatgcActtaaggagcgctggaaccg	13	8	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:42930028A>G	uc003otd.2	+	2	291	c.285A>G	c.(283-285)GCA>GCG	p.A95A	uc003ote.1_5'Flank	NM_018960	NP_061833	Q14749	GNMT_HUMAN	glycine N-methyltransferase	95					protein homotetramerization|protein modification process|S-adenosylmethionine metabolic process		folic acid binding|glycine binding|glycine N-methyltransferase activity				0	Colorectal(47;0.196)		all cancers(41;0.00196)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0461)		Glycine(DB00145)|S-Adenosylmethionine(DB00118)	TGAAGTATGCACTTAAGGAGC	0.592													0	0	0	0.00632	0	29	50										G	42930028	A	G	42930028	2	3	90	1	0	0	0	0	0	0	0	1	6540	146	6	5		5	GNMT	6	42930028	Silent	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	2529474	42930028	128185039	117	27178										
PKHD1	5314	broad.mit.edu	37	chr6	51887631	51887631	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gaaccaagcagctgaaggcaGacactgtagcattagccagg	12	10	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:51887631G>A	uc003pah.1	-	33	5624	c.5348C>T	c.(5347-5349)TCT>TTT	p.S1783F	PKHD1_uc003pai.2_Missense_Mutation_p.S1783F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1783	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GCTGAAGGCAGACACTGTAGC	0.473													0	0	0	0.005524	0	38	40										A	51887631	G	A	51887631	3	1	90	1	0	0	0	0	1	0	0	0	11971	942	33	1	7055	1	PKHD1	6	51887631	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	8957603	51887631	119227436	118	27179										
KHDC1	80759	broad.mit.edu	37	chr6	73951907	73951907	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgtgaaccaactctccagctGaataagggtgtggctgtgca	12	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:73951907G>A	uc003pgo.2	-	4	886	c.385C>T	c.(385-387)CAG>TAG	p.Q129*	KHDC1_uc011dyl.1_RNA|KHDC1_uc003pgn.3_Nonsense_Mutation_p.Q56*	NM_030568	NP_085045	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	129	KH; atypical.					integral to membrane	RNA binding			skin(1)	1						CTCTCCAGCTGAATAAGGGTG	0.547													0	0	0	0.010729	0	11	58										A	73951907	G	A	73951907	4	1	90	1	0	0	0	0	0	1	0	0	8144	1299	45	1	336	1	KHDC1	6	73951907	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	22064276	73951907	97163160	119	27180										
BACH2	60468	broad.mit.edu	37	chr6	90642597	90642597	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cctctctgacaacagtttctCtttctcacacacctggacag	5	15	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:90642597C>G	uc011eab.1	-	9	2865	c.2056G>C	c.(2056-2058)GAG>CAG	p.E686Q	BACH2_uc003pnw.2_Missense_Mutation_p.E686Q	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	686	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		AACAGTTTCTCTTTCTCACAC	0.473													0	0	0	0.00874	0	43	33										G	90642597	C	G	90642597	3	3	90	1	0	0	0	0	1	0	0	0	1284	922	32	1	473	1	BACH2	6	90642597	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	16690690	90642597	80472470	120	27181										
RTN4IP1	84816	broad.mit.edu	37	chr6	107040127	107040127	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttccttacaagttcactggCatcttgggagcaaactgctg	9	11	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:107040127C>A	uc003prj.2	-	6	1195	c.718G>T	c.(718-720)GCC>TCC	p.A240S	RTN4IP1_uc010kdd.2_Intron|RTN4IP1_uc003prk.2_Missense_Mutation_p.A140S	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	240						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		AGTTCACTGGCATCTTGGGAG	0.398													1	0	1.86277e-20	0.01441	2.04905e-20	56	47										A	107040127	C	A	107040127	3	1	90	1	0	0	0	0	1	0	0	0	13729	710	25	4	488	4	RTN4IP1	6	107040127	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	16397530	107040127	64074940	121	27182										
ROS1	6098	broad.mit.edu	37	chr6	117683989	117683989	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgttgcagcattttccacttGgtaatataaatattctgggg	9	6	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:117683989G>C	uc003pxp.1	-	21	3357	c.3158C>G	c.(3157-3159)CCA>CGA	p.P1053R	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1053	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTTTCCACTTGGTAATATAAA	0.348			T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.013537	0	13	55										C	117683989	G	C	117683989	3	2	90	1	0	0	0	0	1	0	0	0	13531	1348	47	4	3977	4	ROS1	6	117683989	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10643862	117683989	53431078	122	27183										
C6orf174	387104	broad.mit.edu	37	chr6	127796661	127796661	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcgcctcggtgatgatggtgCtcgtgtcggcgatgagccgg	18	10	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:127796661C>G	uc003qbd.2	-	6	3375	c.2510G>C	c.(2509-2511)AGC>ACC	p.S837T	C6orf174_uc003qbc.2_5'UTR	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	837						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		GATGATGGTGCTCGTGTCGGC	0.662													0	0	0	0.01441	0	55	148										G	127796661	C	G	127796661	3	3	90	1	0	0	0	0	1	0	0	0	2345	797	28	4	341	4	C6orf174	6	127796661	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	10112672	127796661	43318406	123	27184										
SAMD3	154075	broad.mit.edu	37	chr6	130535635	130535635	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gttgctgaaccatccgatcaTtaagtgcaagaagagcggcc	11	10	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:130535635T>C	uc003qbv.2	-	5	442	c.116A>G	c.(115-117)AAT>AGT	p.N39S	SAMD3_uc003qbx.2_Missense_Mutation_p.N39S|SAMD3_uc003qbw.2_Missense_Mutation_p.N39S|SAMD3_uc010kfg.1_Missense_Mutation_p.N39S|SAMD3_uc003qby.2_Missense_Mutation_p.N39S|SAMD3_uc003qbz.1_5'UTR	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	39	SAM.									ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CATCCGATCATTAAGTGCAAG	0.408													0	0	0	0.01441	0	60	58										C	130535635	T	C	130535635	3	2	90	1	0	0	0	0	1	0	0	0	13820	1493	52	5	1498	5	SAMD3	6	130535635	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	2738974	130535635	40579432	124	27185										
SMOC2	64094	broad.mit.edu	37	chr6	169064760	169064760	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttttttcctgctagcccccaGaggtcatgctgaaagtacgt	9	11	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr6:169064760G>A	uc003qws.1	+	12	1312	c.1292G>A	c.(1291-1293)AGA>AAA	p.R431K	SMOC2_uc003qwr.1_Missense_Mutation_p.R442K|SMOC2_uc011egu.1_Missense_Mutation_p.R108K	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	431					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CTAGCCCCCAGAGGTCATGCT	0.299													0	0	0	0.010729	0	10	73										A	169064760	G	A	169064760	3	1	90	1	0	0	0	0	1	0	0	0	14802	942	33	1	1371	1	SMOC2	6	169064760	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	38529125	169064760	2050307	125	27186										
INTS1	26173	broad.mit.edu	37	chr7	1524940	1524940	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cctcacctgctgcagggccaGggctgtggtgctcctgacgc	14	15	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:1524940G>C	uc003skn.2	-	23	3243	c.3142C>G	c.(3142-3144)CTG>GTG	p.L1048V	INTS1_uc003skp.1_Missense_Mutation_p.L395V	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1048					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		TGCAGGGCCAGGGCTGTGGTG	0.687													0	0	0	0.00245	0	14	89										C	1524940	G	C	1524940	3	2	90	1	0	0	0	0	1	0	0	0	7775	991	35	4	3534	4	INTS1	7	1524940	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		1524940	157613723	126	27187										
NXPH1	30010	broad.mit.edu	37	chr7	8791209	8791209	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caaggctaccaagaacacacTctgcaactatgacccttcaa	5	14	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:8791209T>C	uc003srv.2	+	3	1537	c.626T>C	c.(625-627)CTC>CCC	p.L209P	NXPH1_uc011jxh.1_Missense_Mutation_p.L92P	NM_152745	NP_689958	P58417	NXPH1_HUMAN	neurexophilin 1 precursor	209	V (Cys-rich).					extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		AAGAACACACTCTGCAACTAT	0.413													0	0	0	0.008291	0	10	72										C	8791209	T	C	8791209	3	2	90	1	0	0	0	0	1	0	0	0	10790	1551	54	5	632	5	NXPH1	7	8791209	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	7266269	8791209	150347454	127	27188										
FAM126A	84668	broad.mit.edu	37	chr7	23004031	23004040	+	Splice_Site	DEL	TACAAGGCAA	TACAAGGCAA	-													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttcgcatatgatgagatactTacaaggcaaaataaatccct							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:23004031_23004040delTACAAGGCAA	uc003svm.3	-	8	998	c.743_splice	c.e8+1	p.F248_splice	FAM126A_uc003svn.3_Splice_Site_p.F104_splice	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A							cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						ATGAGATACTTACAAGGCAAAATAAATCCC	0.3																		32	34	---	---								-	23004040	TACAAGGCAA	-	23004031	8	5	90	1	0	1	0	1	0	0	1	0	5429	1769	61	0		0	FAM126A	7	23004031	Splice_Site	DEL	TACAAGGCAA	TCGA-FJ-A3ZF-01A-11D-A23M-08	14212822	23004031	136134632	128	27189										
HECW1	23072	broad.mit.edu	37	chr7	43484767	43484767	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	actccagccccaggcaaggcGgggaccacagttgcgagggc	15	14	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:43484767G>A	uc003tid.1	+	11	2601	c.1996G>A	c.(1996-1998)GGG>AGG	p.G666R	HECW1_uc011kbi.1_Missense_Mutation_p.G666R	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	666					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGGCAAGGCGGGGACCACAG	0.692													0	0	0	0.001855	0	10	78										A	43484767	G	A	43484767	3	1	90	1	0	0	0	0	1	0	0	0	7042	1116	39	2	2030	2	HECW1	7	43484767	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	20480736	43484767	115653896	129	27190										
SEMA3E	9723	broad.mit.edu	37	chr7	83035312	83035312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cattcctggtactgagcaaaCgagtctcgcttttaggaaag	10	9	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:83035312C>T	uc003uhy.1	-	8	1343	c.877G>A	c.(877-879)GTT>ATT	p.V293I		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	293	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				ACTGAGCAAACGAGTCTCGCT	0.348													0	0	0	0.01441	0	63	78										T	83035312	C	T	83035312	3	4	90	1	0	0	0	0	1	0	0	0	14028	536	19	2	1490	2	SEMA3E	7	83035312	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	39550545	83035312	76103351	130	27191										
ZNF804B	219578	broad.mit.edu	37	chr7	88963539	88963539	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agaacagagaaaaatctttaGataaaacagaaagagttagc	8	4	1	5			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:88963539G>C	uc011khi.1	+	4	1781	c.1243G>C	c.(1243-1245)GAT>CAT	p.D415H		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	415						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAAATCTTTAGATAAAACAGA	0.368										HNSCC(36;0.09)			0	0	0	0.004482	0	9	94										C	88963539	G	C	88963539	3	2	90	1	0	0	0	0	1	0	0	0	18168	942	33	1	1257	1	ZNF804B	7	88963539	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5928227	88963539	70175124	131	27192										
GAL3ST4	79690	broad.mit.edu	37	chr7	99758558	99758560	+	In_Frame_Del	DEL	TGT	TGT	-													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gacaatggaaaaaaagaagcTgtcagaaggcatgacctgaa							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:99758558_99758560delTGT	uc003utt.2	-	3	1469_1471	c.452_454delACA	c.(451-456)GACAGC>GGC	p.151_152DS>G	C7orf43_uc003utr.2_5'Flank|C7orf43_uc003uts.2_5'Flank|GAL3ST4_uc003utu.2_In_Frame_Del_p.151_152DS>G|GAL3ST4_uc010lgq.2_In_Frame_Del_p.89_90DS>G	NM_024637	NP_078913	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	151_152	Lumenal (Potential).				cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(3)	3	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AAAAAGAAGCTGTCAGAAGGCAT	0.512																		37	64	---	---								-	99758560	TGT	-	99758558	7	5	90	1	0	1	0	1	0	0	0	0	6200	1580	55	0	1010	0	GAL3ST4	7	99758558	In_Frame_Del	DEL	TGT	TCGA-FJ-A3ZF-01A-11D-A23M-08	10795019	99758558	59380105	132	27193										
SRRT	51593	broad.mit.edu	37	chr7	100485476	100485476	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcccagccacctggccccgcCcagagtaagatacgatccat	9	17	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:100485476C>T	uc003uwy.2	+	18	2590	c.2322C>T	c.(2320-2322)GCC>GCT	p.A774A	SRRT_uc010lhl.1_Silent_p.A773A|SRRT_uc003uxa.2_Silent_p.A773A|SRRT_uc003uwz.2_Silent_p.A774A	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	774	Pro-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						CTGGCCCCGCCCAGAGTAAGA	0.532													0	0	0	0.000602	0	5	150										T	100485476	C	T	100485476	2	4	90	1	0	0	0	0	0	0	0	1	15171	610	22	2		2	SRRT	7	100485476	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	726918	100485476	58653187	133	27194										
WNT2	7472	broad.mit.edu	37	chr7	116960744	116960744	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cacgccctggctaatggcacGcatcacatctggatgtcggt	11	13	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:116960744G>A	uc003viz.2	-	2	487	c.187C>T	c.(187-189)CGT>TGT	p.R63C	WNT2_uc003vja.2_5'UTR	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	63					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CTAATGGCACGCATCACATCT	0.607													0	0	0	0.013726	0	35	6										A	116960744	G	A	116960744	3	1	90	1	0	0	0	0	1	0	0	0	17383	1087	38	2	911	2	WNT2	7	116960744	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	16475268	116960744	42177919	134	27195										
OPN1SW	611	broad.mit.edu	37	chr7	128415628	128415628	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tccgaaggacacgttgaccaGaatgtagttgaggggctgcc	14	9	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:128415628G>C	uc003vnt.3	-	1	217	c.217C>G	c.(217-219)CTG>GTG	p.L73V		NM_001708	NP_001699	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	73	Helical; Name=2; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0						ACGTTGACCAGAATGTAGTTG	0.537													0	0	0	0.01441	0	174	41										C	128415628	G	C	128415628	3	2	90	1	0	0	0	0	1	0	0	0	10880	933	33	1	849	1	OPN1SW	7	128415628	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	11454884	128415628	30723035	135	27196										
FLNC	2318	broad.mit.edu	37	chr7	128481267	128481267	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caagccaagatcgaatgtgaCgacaagggggatggctcctg	14	9	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:128481267C>A	uc003vnz.3	+	12	2066	c.1857C>A	c.(1855-1857)GAC>GAA	p.D619E	FLNC_uc003voa.3_Missense_Mutation_p.D619E	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	619	Filamin 4.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCGAATGTGACGACAAGGGGG	0.627													1	0	2.48551e-13	0.00499	2.66355e-13	15	191										A	128481267	C	A	128481267	3	1	90	1	0	0	0	0	1	0	0	0	5935	535	19	4	1903	4	FLNC	7	128481267	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	65639	128481267	30657396	136	27197										
C7orf33	202865	broad.mit.edu	37	chr7	148288208	148288208	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atttaacttgtcatatgccaCgggaagacataaggtaagtt	9	6	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr7:148288208C>A	uc003wew.2	+	1	552	c.191C>A	c.(190-192)ACG>AAG	p.T64K		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	64										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TCATATGCCACGGGAAGACAT	0.473													1	0	5.77035e-48	0.01441	6.66083e-48	101	27										A	148288208	C	A	148288208	3	1	90	1	0	0	0	0	1	0	0	0	2388	536	19	4	193	4	C7orf33	7	148288208	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	19806941	148288208	10850455	137	27198										
MSR1	4481	broad.mit.edu	37	chr8	15978045	15978045	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caaattgtaccccactggccGctgtggagtatctccaccct	8	15	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:15978045G>T	uc003wwz.2	-	9	1302	c.1104C>A	c.(1102-1104)AGC>AGA	p.S368R	MSR1_uc010lsu.2_Missense_Mutation_p.S386R|MSR1_uc003wxa.2_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	368	SRCR.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCCACTGGCCGCTGTGGAGTA	0.517													1	0	1.61004e-24	0.01441	1.79213e-24	49	10										T	15978045	G	T	15978045	3	4	90	1	0	0	0	0	1	0	0	0	9886	1078	38	4	259	4	MSR1	8	15978045	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		15978045	130385977	138	27199										
KCNU1	157855	broad.mit.edu	37	chr8	36693884	36693884	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tactgcaatcccataacaagGtatagtaacattctagcata	5	9	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:36693884G>A	uc010lvw.2	+	13	1452	c.1365_splice	c.e13+1	p.K455_splice	KCNU1_uc003xjw.2_Splice_Site	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1							voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCATAACAAGGTATAGTAACA	0.333													0	0	0	0.004672	0	3	21										A	36693884	G	A	36693884	5	1	90	1	0	0	0	0	0	0	1	0	8093	1275	44	2	1416	2	KCNU1	8	36693884	Splice_Site	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	20715839	36693884	109670138	139	27200										
ZFHX4	79776	broad.mit.edu	37	chr8	77763532	77763532	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtgaagctgaacttcaacagCtatatgcctccttgcccgtg	9	12	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:77763532C>T	uc003yav.2	+	10	4627	c.4240C>T	c.(4240-4242)CTA>TTA	p.L1414L	ZFHX4_uc003yau.1_Silent_p.L1459L|ZFHX4_uc003yaw.1_Silent_p.L1414L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1414						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTCAACAGCTATATGCCTC	0.493										HNSCC(33;0.089)			0	0	0	0.001855	0	13	38										T	77763532	C	T	77763532	2	4	90	1	0	0	0	0	0	0	0	1	17632	796	28	2		2	ZFHX4	8	77763532	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	41069648	77763532	68600490	140	27201										
VPS13B	157680	broad.mit.edu	37	chr8	100443874	100443874	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggaattgtttggaatgcagtGaagcatctcacactacaggt	11	7	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:100443874G>A	uc003yiv.2	+	22	3303	c.3192G>A	c.(3190-3192)GTG>GTA	p.V1064V	VPS13B_uc003yiw.2_Silent_p.V1064V|VPS13B_uc003yiu.1_Silent_p.V1064V|VPS13B_uc003yix.1_Silent_p.V534V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1064					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GGAATGCAGTGAAGCATCTCA	0.308													0	0	0	0.00499	0	18	54										A	100443874	G	A	100443874	2	1	90	1	0	0	0	0	0	0	0	1	17187	1277	45	1		1	VPS13B	8	100443874	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	22680342	100443874	45920148	141	27202										
PKHD1L1	93035	broad.mit.edu	37	chr8	110457235	110457235	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	attatacggccattgaatgtGaaacatcccctgctgcccaa	7	12	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:110457235G>A	uc003yne.2	+	38	5241	c.5137G>A	c.(5137-5139)GAA>AAA	p.E1713K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1713	IPT/TIG 9.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATTGAATGTGAAACATCCCC	0.443										HNSCC(38;0.096)			0	0	0	0.006214	0	9	283										A	110457235	G	A	110457235	3	1	90	1	0	0	0	0	1	0	0	0	11972	1291	45	1	5287	1	PKHD1L1	8	110457235	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10013361	110457235	35906787	142	27203										
CSMD3	114788	broad.mit.edu	37	chr8	114327003	114327003	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttaagtccttttaaagttccAccacatgtataaataaatcc	3	9	0	0	rs148820468		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:114327003A>T	uc003ynu.2	-	2	357	c.198T>A	c.(196-198)GGT>GGA	p.G66G	CSMD3_uc003ynt.2_Silent_p.G26G|CSMD3_uc011lhx.1_Silent_p.G66G|CSMD3_uc010mcx.1_Silent_p.G66G|CSMD3_uc003ynx.3_Silent_p.G66G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	66	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTAAAGTTCCACCACATGTAT	0.313										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.00632	0	29	63										T	114327003	A	T	114327003	2	4	90	1	0	0	0	0	0	0	0	1	3946	146	6	5		5	CSMD3	8	114327003	Silent	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	3869768	114327003	32037019	143	27204										
FAM84B	157638	broad.mit.edu	37	chr8	127569335	127569335	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	taggtactcagcgccgccgaGcccggcgcgaagctcttctg	13	15	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:127569335G>C	uc003yrz.1	-	2	584	c.300C>G	c.(298-300)GGC>GGG	p.G100G		NM_174911	NP_777571	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	100						cytoplasm|plasma membrane	protein binding				0	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			GCGCCGCCGAGCCCGGCGCGA	0.657													0	0	0	0.01441	0	48	21										C	127569335	G	C	127569335	2	2	90	1	0	0	0	0	0	0	0	1	5642	958	34	4		4	FAM84B	8	127569335	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	13242332	127569335	18794687	144	27205										
PLEC	5339	broad.mit.edu	37	chr8	144992886	144992886	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tggtagatgctcagtgtctgCctggaaccgggcaggtagac	15	9	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:144992886C>G	uc003zaf.1	-	32	11684	c.11514G>C	c.(11512-11514)AGG>AGC	p.R3838S	PLEC_uc003zab.1_Missense_Mutation_p.R3701S|PLEC_uc003zac.1_Missense_Mutation_p.R3705S|PLEC_uc003zad.2_Missense_Mutation_p.R3701S|PLEC_uc003zae.1_Missense_Mutation_p.R3669S|PLEC_uc003zag.1_Missense_Mutation_p.R3679S|PLEC_uc003zah.2_Missense_Mutation_p.R3687S|PLEC_uc003zaj.2_Missense_Mutation_p.R3728S	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3838	Globular 2.|Plectin 17.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCAGTGTCTGCCTGGAACCGG	0.662													0	0	0	0.014323	0	22	88										G	144992886	C	G	144992886	3	3	90	1	0	0	0	0	1	0	0	0	12052	738	26	4	2544	4	PLEC	8	144992886	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	17423551	144992886	1371136	145	27206										
GPT	2875	broad.mit.edu	37	chr8	145731256	145731256	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtgcagacccgcgagtgcatCgaggccgtgatccgcttcgc	14	14	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr8:145731256C>T	uc011lli.1	+	7	922	c.765C>T	c.(763-765)ATC>ATT	p.I255I	GPT_uc011llj.1_Silent_p.I255I|GPT_uc003zdh.3_Silent_p.I255I	NM_005309	NP_005300	P24298	ALAT1_HUMAN	glutamic pyruvate transaminase	255					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|central_nervous_system(1)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GCGAGTGCATCGAGGCCGTGA	0.736													0	0	0	0.001168	0	5	12										T	145731256	C	T	145731256	2	4	90	1	0	0	0	0	0	0	0	1	6737	874	31	1		1	GPT	8	145731256	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	738370	145731256	632766	146	27207										
DMRT2	10655	broad.mit.edu	37	chr9	1056399	1056399	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agctgctgctctgtttctgcCcaaccgcatggtgcctggac	11	14	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:1056399C>G	uc003zha.2	+	4	1012	c.812C>G	c.(811-813)CCC>CGC	p.P271R	DMRT2_uc003zgx.3_Missense_Mutation_p.P38R|DMRT2_uc010mgz.2_Missense_Mutation_p.P38R|DMRT2_uc003zgy.3_Missense_Mutation_p.P115R|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.P271R	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	271					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		CTGTTTCTGCCCAACCGCATG	0.473													0	0	0	0.010504	0	21	154										G	1056399	C	G	1056399	3	3	90	1	0	0	0	0	1	0	0	0	4586	623	22	4	879	4	DMRT2	9	1056399	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		1056399	140157032	147	27208										
SMARCA2	6595	broad.mit.edu	37	chr9	2104016	2104016	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggttcagggctgaactgtatCgggcctcagggaagtttgag	16	7	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:2104016C>T	uc003zhc.2	+	23	3238	c.3139C>T	c.(3139-3141)CGG>TGG	p.R1047W	SMARCA2_uc003zhd.2_Missense_Mutation_p.R1047W|SMARCA2_uc010mha.2_Missense_Mutation_p.R980W	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1047					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TGAACTGTATCGGGCCTCAGG	0.408													0	0	0	0.01441	0	120	93										T	2104016	C	T	2104016	3	4	90	1	0	0	0	0	1	0	0	0	14769	875	31	1	3225	1	SMARCA2	9	2104016	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1047617	2104016	139109415	148	27209										
C9orf123	90871	broad.mit.edu	37	chr9	7798477	7798477	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tagtgatgtctgtccatgtaCaagtgtctgtccagaacacc	9	10	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:7798477C>T	uc003zki.2	-	2	393	c.349G>A	c.(349-351)GTA>ATA	p.V117I	C9orf123_uc003zkj.2_3'UTR			Q96GE9	CI123_HUMAN	Homo sapiens cDNA FLJ46908 fis, clone FEBRA2004867.	Error:Variant_position_missing_in_Q96GE9_after_alignment						integral to membrane					0		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)		TGTCCATGTACAAGTGTCTGT	0.443													0	0	0	0.00245	0	15	29										T	7798477	C	T	7798477	3	4	90	1	0	0	0	0	1	0	0	0	2453	493	17	2		2	C9orf123	9	7798477	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	5694461	7798477	133414954	149	27210										
TAF1L	138474	broad.mit.edu	37	chr9	32634258	32634258	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggttttgtccctttgtgtttGatatcctccccatcccagat	7	12	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:32634258G>C	uc003zrg.1	-	1	1410	c.1320C>G	c.(1318-1320)ATC>ATG	p.I440M	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	440					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTTTGTGTTTGATATCCTCCC	0.468													0	0	0	0.01441	0	213	143										C	32634258	G	C	32634258	3	2	90	1	0	0	0	0	1	0	0	0	15520	1280	45	1	4164	1	TAF1L	9	32634258	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	24835781	32634258	108579173	150	27211										
ANKS6	203286	broad.mit.edu	37	chr9	101536318	101536318	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aatggggggatgactgctttCagcttgtcactcgggagtct	14	8	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:101536318C>T	uc004ayu.2	-	9	1683	c.1662G>A	c.(1660-1662)CTG>CTA	p.L554L	ANKS6_uc004ayt.2_Silent_p.L253L|ANKS6_uc004ayv.1_Silent_p.L16L|ANKS6_uc004ayw.1_Silent_p.L136L|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	554										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				TGACTGCTTTCAGCTTGTCAC	0.582													0	0	0	0.007413	0	15	45										T	101536318	C	T	101536318	2	4	90	1	0	0	0	0	0	0	0	1	692	813	29	1		1	ANKS6	9	101536318	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	68902060	101536318	39677113	151	27212										
NEK6	10783	broad.mit.edu	37	chr9	127113225	127113225	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	catctggatgtccagcacctGagcgtggatgcaccgtgcct	12	13	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:127113225G>A	uc004bog.2	+	10	1090	c.941G>A	c.(940-942)TGA>TAA	p.*314*	NEK6_uc004bof.2_Silent_p.*332*|NEK6_uc004boh.2_Silent_p.*348*|NEK6_uc010mwj.2_Silent_p.*267*|NEK6_uc010mwk.2_Silent_p.*314*|NEK6_uc004boi.2_Silent_p.*314*|LOC100129034_uc010mwl.2_5'Flank	NM_014397	NP_055212	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6 isoform 2	314					apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|kidney(1)	3						TCCAGCACCTGAGCGTGGATG	0.562													0	0	0	0.003954	0	25	41										A	127113225	G	A	127113225	2	1	90	1	0	0	0	0	0	0	0	1	10328	1285	45	1		1	NEK6	9	127113225	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	25576907	127113225	14100206	152	27213										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:137328351C>A	uc004cfb.2	+	10	1442	c.1280C>A	c.(1279-1281)TCC>TAC	p.S427Y	RXRA_uc004cfc.1_Missense_Mutation_p.S330Y	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													1	0	5.05997e-48	0.01441	5.85891e-48	73	47										A	137328351	C	A	137328351	3	1	90	1	0	0	0	0	1	0	0	0	13763	855	30	3	1318	3	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	10215126	137328351	3885080	153	27214										
COL5A1	1289	broad.mit.edu	37	chr9	137704337	137704337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agaagggtgagacaggagacGtgggccagatggtaagtgtg	19	4	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr9:137704337G>A	uc004cfe.2	+	47	4115	c.3733G>A	c.(3733-3735)GTG>ATG	p.V1245M		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1245	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GACAGGAGACGTGGGCCAGAT	0.537													0	0	0	0.01441	0	45	35										A	137704337	G	A	137704337	3	1	90	1	0	0	0	0	1	0	0	0	3696	1145	40	2	3919	2	COL5A1	9	137704337	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	375986	137704337	3509094	154	27215										
ITGA8	8516	broad.mit.edu	37	chr10	15701026	15701026	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccgtgaaattctgaataaacGtcatatccgtagagttaatg	8	7	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:15701026G>A	uc001ioc.1	-	10	920	c.920C>T	c.(919-921)ACG>ATG	p.T307M	ITGA8_uc010qcb.1_Missense_Mutation_p.T292M	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	307	Extracellular (Potential).|FG-GAP 4.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CTGAATAAACGTCATATCCGT	0.318													0	0	0	0.001855	0	12	31										A	15701026	G	A	15701026	3	1	90	1	0	0	0	0	1	0	0	0	7882	1145	40	2	2355	2	ITGA8	10	15701026	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		15701026	119833721	155	27216										
WAC	51322	broad.mit.edu	37	chr10	28884845	28884845	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	taccccaagcactgttccttCtagtccatttacgctacagt	5	14	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:28884845C>G	uc001iuf.2	+	7	879	c.794C>G	c.(793-795)TCT>TGT	p.S265C	WAC_uc001iud.2_Missense_Mutation_p.S220C|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Missense_Mutation_p.S220C|WAC_uc001iug.2_Intron|WAC_uc001iuh.2_Missense_Mutation_p.S220C	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	265					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						ACTGTTCCTTCTAGTCCATTT	0.463													0	0	0	0.01441	0	49	127										G	28884845	C	G	28884845	3	3	90	1	0	0	0	0	1	0	0	0	17244	913	32	1	820	1	WAC	10	28884845	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	13183819	28884845	106649902	156	27217										
WAC	51322	broad.mit.edu	37	chr10	28906604	28906604	+	Missense_Mutation	SNP	G	G	C													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aggcatcaagattacgcgaaGaagcgcataacatgggaact							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:28906604G>C	uc001iuf.2	+	13	1850	c.1765G>C	c.(1765-1767)GAA>CAA	p.E589Q	WAC_uc001iud.2_Missense_Mutation_p.E544Q|WAC_uc001iue.2_Missense_Mutation_p.E279Q|WAC_uc001iug.2_Missense_Mutation_p.E486Q|WAC_uc001iuh.2_Missense_Mutation_p.E540Q	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	589					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						ATTACGCGAAGAAGCGCATAA	0.289													0	0	0	0.001855	0	14	29										C	28906604	G	C	28906604	3	2	90	1	0	0	0	0	1	0	0	0	17244	943	33	1	1815	1	WAC	10	28906604	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	21759	28906604	106628143	157	27218	134	2								
WAC	51322	broad.mit.edu	37	chr10	28906611	28906611	+	Missense_Mutation	SNP	A	A	G													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aagattacgcgaagaagcgcAtaacatgggaactattcaca							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:28906611A>G	uc001iuf.2	+	13	1857	c.1772A>G	c.(1771-1773)CAT>CGT	p.H591R	WAC_uc001iud.2_Missense_Mutation_p.H546R|WAC_uc001iue.2_Missense_Mutation_p.H281R|WAC_uc001iug.2_Missense_Mutation_p.H488R|WAC_uc001iuh.2_Missense_Mutation_p.H542R	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	591					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						GAAGAAGCGCATAACATGGGA	0.299													0	0	0	0.006122	0	17	29										G	28906611	A	G	28906611	3	3	90	1	0	0	0	0	1	0	0	0	17244	217	8	5	1822	5	WAC	10	28906611	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	7	28906611	106628136	158	27219	134	2								
A1CF	29974	broad.mit.edu	37	chr10	52601629	52601629	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aggcggagcttacctaatttCataattattaagttgcttga	8	6	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:52601629C>T	uc001jjj.2	-	5	546	c.358G>A	c.(358-360)GAA>AAA	p.E120K	A1CF_uc010qhn.1_Missense_Mutation_p.E128K|A1CF_uc001jji.2_Missense_Mutation_p.E120K|A1CF_uc001jjh.2_Missense_Mutation_p.E128K|A1CF_uc010qho.1_Missense_Mutation_p.E128K|A1CF_uc009xov.2_Missense_Mutation_p.E120K|A1CF_uc001jjk.1_Missense_Mutation_p.E120K	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	120	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TACCTAATTTCATAATTATTA	0.318													0	0	0	0.004007	0	13	36										T	52601629	C	T	52601629	3	4	90	1	0	0	0	0	1	0	0	0	2	835	29	1	1462	1	A1CF	10	52601629	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	23695018	52601629	82933118	159	27220										
ANK3	288	broad.mit.edu	37	chr10	61830970	61830970	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cgctcaactgctgtttcctcCactgtagtctgcttaaggga	9	12	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:61830970C>T	uc001jky.2	-	37	9861	c.9669G>A	c.(9667-9669)GTG>GTA	p.V3223V	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3223					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CTGTTTCCTCCACTGTAGTCT	0.473													0	0	0	0.001168	0	6	202										T	61830970	C	T	61830970	2	4	90	1	0	0	0	0	0	0	0	1	622	581	21	2		2	ANK3	10	61830970	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	9229341	61830970	73703777	160	27221										
ANK3	288	broad.mit.edu	37	chr10	61836204	61836204	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgttgctcctgtactccgttCaactgtttcttaaattttaa	5	9	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:61836204C>T	uc001jky.2	-	37	4627	c.4435G>A	c.(4435-4437)GAA>AAA	p.E1479K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron|ANK3_uc009xpc.1_RNA	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1479					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTACTCCGTTCAACTGTTTCT	0.378													0	0	0	0.007291	0	30	10										T	61836204	C	T	61836204	3	4	90	1	0	0	0	0	1	0	0	0	622	835	29	1	9039	1	ANK3	10	61836204	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	5234	61836204	73698543	161	27222										
JMJD1C	221037	broad.mit.edu	37	chr10	64960429	64960429	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atctttcaatactgaacgagGaatgccagctgtaaaatcag	8	8	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:64960429G>A	uc001jmn.2	-	11	5383	c.5083C>T	c.(5083-5085)CCT>TCT	p.P1695S	JMJD1C_uc001jml.2_Missense_Mutation_p.P1476S|JMJD1C_uc001jmm.2_Missense_Mutation_p.P1407S|JMJD1C_uc010qiq.1_Missense_Mutation_p.P1513S|JMJD1C_uc009xpi.2_Missense_Mutation_p.P1513S|JMJD1C_uc009xpj.1_Intron|JMJD1C_uc009xpk.1_Intron	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1695					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					ACTGAACGAGGAATGCCAGCT	0.373													0	0	0	0.00308	0	8	29										A	64960429	G	A	64960429	3	1	90	1	0	0	0	0	1	0	0	0	7950	1174	41	1	2603	1	JMJD1C	10	64960429	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	3124225	64960429	70574318	162	27223										
PPRC1	23082	broad.mit.edu	37	chr10	103906993	103906993	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgcaggtcagccagcccctCaagccagggctggcagggcc	14	16	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:103906993C>T	uc001kum.2	+	9	4283	c.4244C>T	c.(4243-4245)TCA>TTA	p.S1415L	PPRC1_uc001kun.2_Missense_Mutation_p.S1295L|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1415	Arg-rich.|Necessary for interaction with CREB1 and NRF1.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCCAGCCCCTCAAGCCAGGGC	0.612													0	0	0	0.01441	0	68	35										T	103906993	C	T	103906993	3	4	90	1	0	0	0	0	1	0	0	0	12410	838	29	1	4278	1	PPRC1	10	103906993	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	38946564	103906993	31627754	163	27224										
PDCD11	22984	broad.mit.edu	37	chr10	105202183	105202183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agatcgagaaggcccgtgccGtggctgagagggcccttaag	16	10	0	3	rs140495953		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:105202183G>A	uc001kwy.1	+	32	5008	c.4921G>A	c.(4921-4923)GTG>ATG	p.V1641M		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1641					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GGCCCGTGCCGTGGCTGAGAG	0.587													0	0	0	0.01441	0	80	43										A	105202183	G	A	105202183	3	1	90	1	0	0	0	0	1	0	0	0	11617	1145	40	2	5043	2	PDCD11	10	105202183	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1295190	105202183	30332564	164	27225										
ACADSB	36	broad.mit.edu	37	chr10	124813245	124813245	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggagcttccaacatccagttGaacaccattgcaaagcatat	7	11	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:124813245G>A	uc001lhb.2	+	11	1380	c.1263G>A	c.(1261-1263)TTG>TTA	p.L421L	ACADSB_uc010qub.1_Silent_p.L319L	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	421					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	ACATCCAGTTGAACACCATTG	0.398													0	0	0	0.005443	0	23	93										A	124813245	G	A	124813245	2	1	90	1	0	0	0	0	0	0	0	1	115	1281	45	1		1	ACADSB	10	124813245	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	19611062	124813245	10721502	165	27226										
CHST15	51363	broad.mit.edu	37	chr10	125801927	125801927	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccagataatcttccacgggaTagcggtctcgcagcccatct	9	14	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:125801927T>G	uc001lhl.2	-	3	1436	c.923A>C	c.(922-924)TAT>TCT	p.Y308S	CHST15_uc001lhm.2_Missense_Mutation_p.Y308S|CHST15_uc001lhn.2_Missense_Mutation_p.Y308S|CHST15_uc010que.1_Missense_Mutation_p.Y308S|CHST15_uc001lho.2_Missense_Mutation_p.Y308S	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	308	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						TTCCACGGGATAGCGGTCTCG	0.537													0	0	0	0.005524	0	41	32										G	125801927	T	G	125801927	3	3	90	1	0	0	0	0	1	0	0	0	3403	1406	49	5	782	5	CHST15	10	125801927	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	988682	125801927	9732820	166	27227										
FANK1	92565	broad.mit.edu	37	chr10	127697960	127697960	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agagtgtagtctccttattaGaagaaaggaaaaaaaagcag	10	4	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr10:127697960G>C	uc001ljh.3	+	11	1095	c.991G>C	c.(991-993)GAA>CAA	p.E331Q	FANK1_uc009yan.2_Missense_Mutation_p.E357Q|FANK1_uc001lji.2_3'UTR	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	331						cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				CTCCTTATTAGAAGAAAGGAA	0.413													0	0	0	0.006122	0	19	51										C	127697960	G	C	127697960	3	2	90	1	0	0	0	0	1	0	0	0	5672	943	33	1	1033	1	FANK1	10	127697960	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1896033	127697960	7836787	167	27228										
IGF2	3481	broad.mit.edu	37	chr11	2154863	2154863	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcactcctcaacgatgccacGgctgcgacggctcacacggc	11	17	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:2154863G>A	uc009yde.2	-	3	293	c.190C>T	c.(190-192)CGT>TGT	p.R64C	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Missense_Mutation_p.R64C|IGF2_uc009ydf.2_Missense_Mutation_p.R120C|IGF2_uc001lvh.2_Missense_Mutation_p.R64C|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	64	C.				glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		ACGATGCCACGGCTGCGACGG	0.662													0	0	0	0.010729	0	11	35										A	2154863	G	A	2154863	3	1	90	1	0	0	0	0	1	0	0	0	7572	1116	39	2	360	2	IGF2	11	2154863	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		2154863	132851653	168	27229										
DNHD1	144132	broad.mit.edu	37	chr11	6590023	6590023	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccccacccaggcactacctCtgctcctcctccatggcctc	5	23	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:6590023C>G	uc001mdw.3	+	39	13354	c.12790C>G	c.(12790-12792)CTG>GTG	p.L4264V	DNHD1_uc001mea.3_Missense_Mutation_p.L533V|DNHD1_uc001meb.2_Missense_Mutation_p.L532V|DNHD1_uc001mec.2_Missense_Mutation_p.L532V|DNHD1_uc010rao.1_Missense_Mutation_p.L522V|DNHD1_uc009yfg.2_5'UTR	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4264					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GGCACTACCTCTGCTCCTCCT	0.602													0	0	0	0.00499	0	17	14										G	6590023	C	G	6590023	3	3	90	1	0	0	0	0	1	0	0	0	4668	912	32	1	12945	1	DNHD1	11	6590023	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	4435160	6590023	128416493	169	27230										
RBMXL2	27288	broad.mit.edu	37	chr11	7111126	7111126	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtcccttgagaggctacagcGaccgagacggctacggaggt	15	11	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:7111126G>A	uc001mfc.2	+	1	962	c.775G>A	c.(775-777)GAC>AAC	p.D259N		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	259	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGCTACAGCGACCGAGACGG	0.662													0	0	0	0.014323	0	19	46										A	7111126	G	A	7111126	3	1	90	1	0	0	0	0	1	0	0	0	13154	1058	37	1	777	1	RBMXL2	11	7111126	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	521103	7111126	127895390	170	27231										
PIK3C2A	5286	broad.mit.edu	37	chr11	17113138	17113138	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gatgaaaagagtaccatttcGgtaagagatggataatttca	10	4	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:17113138G>A	uc001mmq.3	-	30	4774	c.4708C>T	c.(4708-4710)CGA>TGA	p.R1570*	PIK3C2A_uc009ygu.1_Nonsense_Mutation_p.R173*|PIK3C2A_uc010rcw.1_Nonsense_Mutation_p.R1190*|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1570	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GTACCATTTCGGTAAGAGATG	0.388													0	0	0	0.009718	0	42	33										A	17113138	G	A	17113138	4	1	90	1	0	0	0	0	0	1	0	0	11909	1124	39	2	364	2	PIK3C2A	11	17113138	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10002012	17113138	117893378	171	27232										
TCP11L1	55346	broad.mit.edu	37	chr11	33078731	33078731	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgagtgtgcagctaagtgaaGatcccccagcatatgaccat	10	10	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:33078731G>T	uc001mud.2	+	4	767	c.367G>T	c.(367-369)GAT>TAT	p.D123Y	TCP11L1_uc009yju.2_5'UTR|TCP11L1_uc010rei.1_Missense_Mutation_p.D123Y|TCP11L1_uc001mue.2_Missense_Mutation_p.D123Y|TCP11L1_uc001muf.1_5'Flank	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	123											0						GCTAAGTGAAGATCCCCCAGC	0.433													1	0	3.94896e-32	0.01441	4.44853e-32	70	181										T	33078731	G	T	33078731	3	4	90	1	0	0	0	0	1	0	0	0	15711	942	33	3	377	3	TCP11L1	11	33078731	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	15965593	33078731	101927785	172	27233										
HIPK3	10114	broad.mit.edu	37	chr11	33369461	33369461	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cagcctcttctgaccaatcaGataactttatctgcccctca	4	15	5	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:33369461G>A	uc001mul.1	+	11	2478	c.2208G>A	c.(2206-2208)CAG>CAA	p.Q736Q	HIPK3_uc001mum.1_Silent_p.Q736Q|HIPK3_uc009yjv.1_Silent_p.Q736Q	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	736					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TGACCAATCAGATAACTTTAT	0.438													0	0	0	0.004878	0	39	90										A	33369461	G	A	33369461	2	1	90	1	0	0	0	0	0	0	0	1	7118	933	33	1		1	HIPK3	11	33369461	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	290730	33369461	101637055	173	27234										
MTCH2	23788	broad.mit.edu	37	chr11	47653256	47653256	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cagaacgagcgatcatctctCgagttgtctagaaacaatca	8	10	4	2	rs144753500	byFrequency	TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:47653256C>G	uc010rho.1	-	6	566	c.377G>C	c.(376-378)CGA>CCA	p.R126P	MTCH2_uc001nge.2_5'UTR|MTCH2_uc010rhp.1_Intron	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	126	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane					0						GATCATCTCTCGAGTTGTCTA	0.423													0	0	0	0.010504	0	22	71										G	47653256	C	G	47653256	3	3	90	1	0	0	0	0	1	0	0	0	9914	884	31	1	566	1	MTCH2	11	47653256	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	14283795	47653256	87353260	174	27235										
ARAP1	116985	broad.mit.edu	37	chr11	72423574	72423574	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctcgctcagcagactggccaCgcgcacggcccgtgggactc	13	17	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:72423574C>A	uc001osu.2	-	6	976	c.787G>T	c.(787-789)GTG>TTG	p.V263L	ARAP1_uc001osv.2_Missense_Mutation_p.V263L|ARAP1_uc001osr.2_Missense_Mutation_p.V23L|ARAP1_uc001oss.2_Missense_Mutation_p.V18L|ARAP1_uc009yth.2_Missense_Mutation_p.V18L|ARAP1_uc010rre.1_Missense_Mutation_p.V18L	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	263					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						AGACTGGCCACGCGCACGGCC	0.657													1	0	3.73298e-82	0.01441	4.3766e-82	138	80										A	72423574	C	A	72423574	3	1	90	1	0	0	0	0	1	0	0	0	838	536	19	4	3685	4	ARAP1	11	72423574	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	24770318	72423574	62582942	175	27236										
XRRA1	143570	broad.mit.edu	37	chr11	74641373	74641373	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agcaggttttctgaggcattGatataaatcacagaatgaaa	9	5	2	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:74641373G>C	uc009yub.2	-	6	704	c.372C>G	c.(370-372)ATC>ATG	p.I124M	XRRA1_uc001ovm.2_RNA|XRRA1_uc001ovo.2_Translation_Start_Site|XRRA1_uc001ovq.3_Missense_Mutation_p.I124M|XRRA1_uc001ovp.3_Translation_Start_Site|XRRA1_uc001ovr.2_Translation_Start_Site	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	124	LRR 1.				response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						CTGAGGCATTGATATAAATCA	0.393													0	0	0	0.004672	0	2	5										C	74641373	G	C	74641373	3	2	90	1	0	0	0	0	1	0	0	0	17458	1280	45	1	2062	1	XRRA1	11	74641373	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	2217799	74641373	60365143	176	27237										
MOGAT2	80168	broad.mit.edu	37	chr11	75439964	75439964	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atgggcatctccctcccactCtttcatggccgtggtgtctt	9	14	4	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:75439964C>G	uc010rru.1	+	5	780	c.780C>G	c.(778-780)CTC>CTG	p.L260L	MOGAT2_uc001oww.1_3'UTR|MOGAT2_uc010rrv.1_Silent_p.L178L	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	260					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					CCCTCCCACTCTTTCATGGCC	0.537													0	0	0	0.01441	0	82	46										G	75439964	C	G	75439964	2	3	90	1	0	0	0	0	0	0	0	1	9695	900	32	1		1	MOGAT2	11	75439964	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	798591	75439964	59566552	177	27238										
NOX4	50507	broad.mit.edu	37	chr11	89184974	89184974	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttctgtgatcctcggaggtaAgccaagagtgttcggcacat	12	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:89184974A>G	uc001pct.2	-	3	482	c.243T>C	c.(241-243)GCT>GCC	p.A81A	NOX4_uc009yvr.2_Silent_p.A56A|NOX4_uc001pcu.2_Silent_p.A7A|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Silent_p.A81A|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Silent_p.A81A|NOX4_uc010rtv.1_Silent_p.A57A|NOX4_uc009yvq.2_Silent_p.A57A|NOX4_uc009yvs.1_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	81	Ferric oxidoreductase.|Helical; (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CTCGGAGGTAAGCCAAGAGTG	0.408													0	0	0	0.013537	0	13	90										G	89184974	A	G	89184974	2	3	90	1	0	0	0	0	0	0	0	1	10558	59	3	5		5	NOX4	11	89184974	Silent	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	13745010	89184974	45821542	178	27239										
CASP1	834	broad.mit.edu	37	chr11	104897665	104897665	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gagcccattgtgggatgtctCcaagaaacattatctatgga	10	8	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:104897665C>T	uc010rve.1	-	8	1037	c.1020G>A	c.(1018-1020)TGG>TGA	p.W340*	CASP1_uc001pig.2_Nonsense_Mutation_p.W247*|CASP1_uc001pik.2_Nonsense_Mutation_p.W303*|CASP1_uc010rvf.1_Nonsense_Mutation_p.W247*|CASP1_uc010rvg.1_Nonsense_Mutation_p.W319*|CASP1_uc010rvh.1_Nonsense_Mutation_p.W199*|CASP1_uc010rvi.1_Nonsense_Mutation_p.W24*|CASP1_uc001pim.3_Nonsense_Mutation_p.W340*|CASP1_uc009yxi.2_Nonsense_Mutation_p.W319*|CASP1_uc010rvj.1_Nonsense_Mutation_p.W340*|CASP1_uc009yxj.2_Nonsense_Mutation_p.W185*|CASP1_uc010rvk.1_3'UTR	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	340					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TGGGATGTCTCCAAGAAACAT	0.403													0	0	0	0.013114	0	46	29										T	104897665	C	T	104897665	4	4	90	1	0	0	0	0	0	1	0	0	2668	856	30	1	202	1	CASP1	11	104897665	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	15712691	104897665	30108851	179	27240										
BCO2	83875	broad.mit.edu	37	chr11	112050172	112050172	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caatggctctctacttcgaaTtggacctgggaaattcgagt	10	9	1	0	rs112483486	byFrequency	TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:112050172T>C	uc001pnf.2	+	2	377	c.260T>C	c.(259-261)ATT>ACT	p.I87T	BCO2_uc001pne.1_Intron|BCO2_uc001png.2_Missense_Mutation_p.I87T|BCO2_uc001pnh.2_Missense_Mutation_p.I53T|BCO2_uc010rwt.1_Intron|BCO2_uc009yyn.2_Missense_Mutation_p.I53T|BCO2_uc001pni.2_Missense_Mutation_p.I53T	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	87					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTACTTCGAATTGGACCTGGG	0.493													0	0	0	0.009096	0	4	97										C	112050172	T	C	112050172	3	2	90	1	0	0	0	0	1	0	0	0	1385	1493	52	5	266	5	BCO2	11	112050172	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	7152507	112050172	22956344	180	27241										
SPA17	53340	broad.mit.edu	37	chr11	124561605	124561605	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgtccaggagcaagaaccacCtgagaaaagtgatcctaaac	9	10	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:124561605C>A	uc001qap.2	+	4	375	c.239C>A	c.(238-240)CCT>CAT	p.P80H		NM_017425	NP_059121	Q15506	SP17_HUMAN	sperm autoantigenic protein 17	80					binding of sperm to zona pellucida|ciliary or flagellar motility|signal transduction|spermatogenesis	cytoplasm|flagellum|membrane|motile cilium|primary cilium	cAMP-dependent protein kinase regulator activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0223)		CAAGAACCACCTGAGAAAAGT	0.378													1	0	9.52127e-25	0.01441	1.06297e-24	49	32										A	124561605	C	A	124561605	3	1	90	1	0	0	0	0	1	0	0	0	14971	681	24	4	249	4	SPA17	11	124561605	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	12511433	124561605	10444911	181	27242										
SRPR	6734	broad.mit.edu	37	chr11	126135303	126135303	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cagaatctgcaccagggactCctgtagggcttgctttactg	11	11	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr11:126135303C>G	uc001qdh.2	-	10	1222	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	SRPR_uc010sbm.1_Missense_Mutation_p.E363Q	NM_003139	NP_003130	P08240	SRPR_HUMAN	signal recognition particle receptor	391					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding				0	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		ACCAGGGACTCCTGTAGGGCT	0.557													0	0	0	0.01441	0	49	31										G	126135303	C	G	126135303	3	3	90	1	0	0	0	0	1	0	0	0	15161	864	30	1	765	1	SRPR	11	126135303	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1573698	126135303	8871213	182	27243										
PDE3A	5139	broad.mit.edu	37	chr12	20786637	20786637	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tattttttagctgtggcagaCcatattcccaagggaatcct	8	9	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:20786637C>A	uc001reh.1	+	7	1793	c.1771C>A	c.(1771-1773)CCA>ACA	p.P591T		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	591					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTGTGGCAGACCATATTCCCA	0.418													1	0	2.48551e-13	0.00499	2.66355e-13	18	27										A	20786637	C	A	20786637	3	1	90	1	0	0	0	0	1	0	0	0	11637	507	18	4	1797	4	PDE3A	12	20786637	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		20786637	113065258	183	27244										
C12orf11	55726	broad.mit.edu	37	chr12	27068949	27068949	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcttactgtaatccggtagtCtgtaactcttcctccacatc	5	13	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:27068949C>T	uc001rhk.3	-	11	1771	c.1234G>A	c.(1234-1236)GAC>AAC	p.D412N	C12orf11_uc001rhj.3_Missense_Mutation_p.D37N|C12orf11_uc010sjk.1_Missense_Mutation_p.D311N	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	412					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					ATCCGGTAGTCTGTAACTCTT	0.299													0	0	0	0.012213	0	32	29										T	27068949	C	T	27068949	3	4	90	1	0	0	0	0	1	0	0	0	1675	913	32	1	914	1	C12orf11	12	27068949	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	6282312	27068949	106782946	184	27245										
PTHLH	5744	broad.mit.edu	37	chr12	28116576	28116576	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttggagttaggggacacctCcgaggtagctctgatttcag	13	9	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:28116576C>G	uc001rik.2	-	3	532	c.229G>C	c.(229-231)GAG>CAG	p.E77Q	PTHLH_uc001ril.2_Missense_Mutation_p.E77Q|PTHLH_uc001rim.2_Missense_Mutation_p.E77Q|PTHLH_uc001rin.2_Missense_Mutation_p.E77Q	NM_198966	NP_945317	P12272	PTHR_HUMAN	parathyroid hormone-like hormone isoform 1	77					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)	1	Lung SC(9;0.184)					GGGGACACCTCCGAGGTAGCT	0.507													0	0	0	0.004289	0	34	299										G	28116576	C	G	28116576	3	3	90	1	0	0	0	0	1	0	0	0	12761	864	30	1	316	1	PTHLH	12	28116576	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1047627	28116576	105735319	185	27246										
DENND5B	160518	broad.mit.edu	37	chr12	31568364	31568364	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctcctgagtcagattttcttCtttctggtccgagggcaact	9	11	4	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:31568364C>T	uc001rki.1	-	12	2675	c.2489G>A	c.(2488-2490)AGA>AAA	p.R830K	DENND5B_uc001rkh.1_Missense_Mutation_p.R865K|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	830	RUN 1.					integral to membrane				ovary(1)|central_nervous_system(1)	2						AGATTTTCTTCTTTCTGGTCC	0.333													0	0	0	0.000602	0	4	23										T	31568364	C	T	31568364	3	4	90	1	0	0	0	0	1	0	0	0	4437	913	32	1	1375	1	DENND5B	12	31568364	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3451788	31568364	102283531	186	27247										
C12orf35	55196	broad.mit.edu	37	chr12	32140179	32140179	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gaatatttaaatagtttcagGaataaaaagtacaaaagaag	7	2	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:32140179G>C	uc001rks.2	+	5	5423	c.5009G>C	c.(5008-5010)GGA>GCA	p.G1670A	C12orf35_uc001rkt.2_RNA	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1670										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			ATAGTTTCAGGAATAAAAAGT	0.289													0	0	0	0.006214	0	10	35										C	32140179	G	C	32140179	3	2	90	1	0	0	0	0	1	0	0	0	1682	1174	41	1	5015	1	C12orf35	12	32140179	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	571815	32140179	101711716	187	27248										
PDZRN4	29951	broad.mit.edu	37	chr12	41966494	41966494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggagctcaaatgcaagattcGaaatcatggagagtatgacc	11	7	2	3	rs138042494	byFrequency	TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:41966494G>A	uc010skn.1	+	10	1384	c.1316G>A	c.(1315-1317)CGA>CAA	p.R439Q	PDZRN4_uc001rmq.3_Missense_Mutation_p.R380Q|PDZRN4_uc009zjz.2_Missense_Mutation_p.R378Q|PDZRN4_uc001rmr.2_Missense_Mutation_p.R265Q	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	638							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGCAAGATTCGAAATCATGGA	0.453													0	0	0	0.01441	0	64	32										A	41966494	G	A	41966494	3	1	90	1	0	0	0	0	1	0	0	0	11710	1058	37	1	2024	1	PDZRN4	12	41966494	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	9826315	41966494	91885401	188	27249										
TUBA1C	84790	broad.mit.edu	37	chr12	49666750	49666750	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	accagcctcccactgtggtgCctggcggagacctggccaag	13	15	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:49666750C>A	uc001rtt.1	+	4	1190	c.1090C>A	c.(1090-1092)CCT>ACT	p.P364T	TUBA1C_uc001rts.2_Missense_Mutation_p.P329T|TUBA1C_uc010smh.1_Missense_Mutation_p.P434T|uc010smi.1_5'UTR	NM_032704	NP_116093	Q9BQE3	TBA1C_HUMAN	tubulin alpha 6	364					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0						CACTGTGGTGCCTGGCGGAGA	0.562													1	0	1.15062e-32	0.01441	1.30009e-32	74	48										A	49666750	C	A	49666750	3	1	90	1	0	0	0	0	1	0	0	0	16742	739	26	4	1104	4	TUBA1C	12	49666750	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	7700256	49666750	84185145	189	27250										
PRPH	5630	broad.mit.edu	37	chr12	49691240	49691240	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcggctcgaggaggagctgcGacagctaaaagaggagatgg	18	7	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:49691240G>C	uc001rtu.2	+	6	1172	c.1097G>C	c.(1096-1098)CGA>CCA	p.R366P		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	366	Coil 2.|Rod.						structural molecule activity				0						GAGGAGCTGCGACAGCTAAAA	0.652											OREG0021790	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	10	16										C	49691240	G	C	49691240	3	2	90	1	0	0	0	0	1	0	0	0	12576	1058	37	1	1119	1	PRPH	12	49691240	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	24490	49691240	84160655	190	27251										
AQP2	359	broad.mit.edu	37	chr12	50344837	50344837	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccctgccgtgactgtggcctGcctggtgggctgccacgtct	14	15	1	1	rs144443773		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:50344837G>T	uc001rvn.2	+	1	314	c.224G>T	c.(223-225)TGC>TTC	p.C75F		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	75	Cytoplasmic (Potential).				cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						ACTGTGGCCTGCCTGGTGGGC	0.647													1	0	3.07112e-06	0.010729	3.18171e-06	11	40										T	50344837	G	T	50344837	3	4	90	1	0	0	0	0	1	0	0	0	826	1319	46	4	226	4	AQP2	12	50344837	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	653597	50344837	83507058	191	27252										
KRT83	3889	broad.mit.edu	37	chr12	52713085	52713085	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caggttactctggcagcactCgcggttttggtagaactgca	12	10	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:52713085C>G	uc001saf.2	-	2	511	c.448G>C	c.(448-450)GAG>CAG	p.E150Q		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	150	Rod.|Linker 1.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGCAGCACTCGCGGTTTTGG	0.607													0	0	0	0.01441	0	111	62										G	52713085	C	G	52713085	3	3	90	1	0	0	0	0	1	0	0	0	8497	893	31	1	1065	1	KRT83	12	52713085	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2368248	52713085	81138810	192	27253										
KRT85	3891	broad.mit.edu	37	chr12	52758102	52758102	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccctcaccttctttagaacGacaaactcattctctgctgt	4	15	4	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:52758102G>A	uc001sag.2	-	3	798	c.678C>T	c.(676-678)GTC>GTT	p.V226V		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	226	Rod.|Coil 1B.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTTTAGAACGACAAACTCAT	0.572													0	0	0	0.01441	0	55	42										A	52758102	G	A	52758102	2	1	90	1	0	0	0	0	0	0	0	1	8499	1045	37	1		1	KRT85	12	52758102	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	45017	52758102	81093793	193	27254										
KRT82	3888	broad.mit.edu	37	chr12	52788848	52788848	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gctcagtagcccctggggctCgcaggggacatagagttcac	14	12	2	1	rs140708995		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:52788848C>T	uc001sai.1	-	9	1568	c.1453G>A	c.(1453-1455)GAG>AAG	p.E485K		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	485	Tail.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		CCCTGGGGCTCGCAGGGGACA	0.642													0	0	0	0.009535	0	29	73										T	52788848	C	T	52788848	3	4	90	1	0	0	0	0	1	0	0	0	8496	893	31	1	92	1	KRT82	12	52788848	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	30746	52788848	81063047	194	27255										
ERBB3	2065	broad.mit.edu	37	chr12	56478854	56478854	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	taccattgcccaacctccgcGtggtgcgagggacccaggtc	12	15	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:56478854G>T	uc001sjh.2	+	3	503	c.310G>T	c.(310-312)GTG>TTG	p.V104L	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45L|ERBB3_uc001sjg.2_Missense_Mutation_p.V104L	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517													1	0	1.00155e-58	0.01441	1.16692e-58	94	70										T	56478854	G	T	56478854	3	4	90	1	0	0	0	0	1	0	0	0	5208	1145	40	4	320	4	ERBB3	12	56478854	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	3690006	56478854	77373041	195	27256										
ZC3H10	84872	broad.mit.edu	37	chr12	56515127	56515127	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	taaagaagcaggtcagcaacCtgctggccaccaatgaggta	11	10	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:56515127C>T	uc001sjp.1	+	3	970	c.781C>T	c.(781-783)CTG>TTG	p.L261L		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	261	Potential.						nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			GGTCAGCAACCTGCTGGCCAC	0.552													0	0	0	0.004878	0	36	78										T	56515127	C	T	56515127	2	4	90	1	0	0	0	0	0	0	0	1	17556	680	24	2		2	ZC3H10	12	56515127	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	36273	56515127	77336768	196	27257										
TIMELESS	8914	broad.mit.edu	37	chr12	56818910	56818910	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tggtctaggaccttcttcttCttcttccttctcttcttttg	5	12	7	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:56818910C>T	uc001slf.2	-	14	1773	c.1605G>A	c.(1603-1605)AAG>AAA	p.K535K		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	535					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						Ccttcttcttcttcttccttc	0.418													0	0	0	0.01441	0	67	36										T	56818910	C	T	56818910	2	4	90	1	0	0	0	0	0	0	0	1	15901	912	32	1		1	TIMELESS	12	56818910	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	303783	56818910	77032985	197	27258										
GLI1	2735	broad.mit.edu	37	chr12	57864227	57864227	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcctctcctttcccccctggCtccccaccagagaatggagc	8	19	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:57864227C>T	uc001snx.2	+	12	1782	c.1704C>T	c.(1702-1704)GGC>GGT	p.G568G	GLI1_uc009zpq.2_Silent_p.G440G	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	568					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TCCCCCCTGGCTCCCCACCAG	0.622													0	0	0	0.003954	0	23	100										T	57864227	C	T	57864227	2	4	90	1	0	0	0	0	0	0	0	1	6437	784	28	2		2	GLI1	12	57864227	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1045317	57864227	75987668	198	27259										
CDK4	1019	broad.mit.edu	37	chr12	58143281	58143281	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcttcagagtttccacagaaGagaggcctaaggtgagaagg	14	7	1	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:58143281G>A	uc001spv.2	-	6	866	c.639C>T	c.(637-639)CTC>CTT	p.L213L	CDK4_uc010ssb.1_Silent_p.L93L|CDK4_uc001spw.2_RNA|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	213	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TTCCACAGAAGAGAGGCCTAA	0.408			Mis			melanoma 			Hereditary_Melanoma				0	0	0	0.00245	0	13	39										A	58143281	G	A	58143281	2	1	90	1	0	0	0	0	0	0	0	1	3141	929	33	1		1	CDK4	12	58143281	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	279054	58143281	75708614	199	27260										
C12orf66	144577	broad.mit.edu	37	chr12	64588164	64588164	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtaaaagctaaacttggcaaGaagcatgtttttgagtttca	9	5	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:64588164G>A	uc001srw.3	-	3	855	c.796C>T	c.(796-798)CTT>TTT	p.L266F	C12orf66_uc009zql.2_Missense_Mutation_p.L213F	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	266										ovary(1)	1						AACTTGGCAAGAAGCATGTTT	0.463													0	0	0	0.01441	0	43	109										A	64588164	G	A	64588164	3	1	90	1	0	0	0	0	1	0	0	0	1709	942	33	1	545	1	C12orf66	12	64588164	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	6444883	64588164	69263731	200	27261										
C12orf56	115749	broad.mit.edu	37	chr12	64679744	64679744	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tagtacttacaccagctcatCaaccctttggctttgatttt	5	11	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:64679744C>T	uc001ssa.3	-	5	730	c.730G>A	c.(730-732)GAT>AAT	p.D244N	uc001srx.2_Intron|C12orf56_uc001sry.2_5'UTR|C12orf56_uc001srz.2_5'UTR	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	407											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		ACCAGCTCATCAACCCTTTGG	0.363													0	0	0	0.00308	0	8	13										T	64679744	C	T	64679744	3	4	90	1	0	0	0	0	1	0	0	0	1700	826	29	1	686	1	C12orf56	12	64679744	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	91580	64679744	69172151	201	27262										
PRKAB1	5564	broad.mit.edu	37	chr12	120106160	120106160	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggggacaggcccaagatcctGatggacagccccgaagacgc	14	13	0	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:120106160G>A	uc009zwu.2	+	2	214	c.111G>A	c.(109-111)CTG>CTA	p.L37L	PRKAB1_uc001txg.2_Silent_p.L37L	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	37					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	CCAAGATCCTGATGGACAGCC	0.647													0	0	0	0.007291	0	27	15										A	120106160	G	A	120106160	2	1	90	1	0	0	0	0	0	0	0	1	12495	1277	45	1		1	PRKAB1	12	120106160	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	55426416	120106160	13745735	202	27263										
CIT	11113	broad.mit.edu	37	chr12	120214582	120214582	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gatcactccgtcttcttgctGagacaagatcctcttccaac	6	14	4	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:120214582G>A	uc001txi.1	-	14	1783	c.1730C>T	c.(1729-1731)TCA>TTA	p.S577L	CIT_uc001txh.1_Missense_Mutation_p.S111L|CIT_uc001txj.1_Missense_Mutation_p.S577L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	577	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTTCTTGCTGAGACAAGATC	0.448													0	0	0	0.01441	0	118	54										A	120214582	G	A	120214582	3	1	90	1	0	0	0	0	1	0	0	0	3438	1294	45	1	4489	1	CIT	12	120214582	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	108422	120214582	13637313	203	27264										
TMEM132B	114795	broad.mit.edu	37	chr12	126138414	126138414	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtagtgatgagcaccaaggaGgcagcaatgatattgagggc	15	6	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:126138414G>A	uc001uhe.1	+	9	2403	c.2395G>A	c.(2395-2397)GGC>AGC	p.G799S	TMEM132B_uc001uhf.1_Missense_Mutation_p.G311S	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	799	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCACCAAGGAGGCAGCAATGA	0.458													0	0	0	0.010818	0	31	73										A	126138414	G	A	126138414	3	1	90	1	0	0	0	0	1	0	0	0	16043	1000	35	2	2429	2	TMEM132B	12	126138414	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5923832	126138414	7713481	204	27265										
RIMBP2	23504	broad.mit.edu	37	chr12	130923033	130923033	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggggtcaccccagcctggacGgtaacatcttgtgggggtgc	16	11	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr12:130923033G>A	uc001uil.2	-	9	1646	c.1482C>T	c.(1480-1482)ACC>ACT	p.T494T	RIMBP2_uc001uim.2_Silent_p.T402T|RIMBP2_uc001uin.1_Silent_p.T153T	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	494	Fibronectin type-III 3.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CAGCCTGGACGGTAACATCTT	0.672													0	0	0	0.00245	0	15	9										A	130923033	G	A	130923033	2	1	90	1	0	0	0	0	0	0	0	1	13363	1103	39	2		2	RIMBP2	12	130923033	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	4784619	130923033	2928862	205	27266										
SACS	26278	broad.mit.edu	37	chr13	23929191	23929191	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gacaaggggaaatcagagctCttttccatctccagacgttt	9	10	3	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr13:23929191C>G	uc001uon.2	-	8	2149	c.1560G>C	c.(1558-1560)AAG>AAC	p.K520N	SACS_uc001uoo.2_Missense_Mutation_p.K373N|SACS_uc001uop.1_Missense_Mutation_p.K307N|SACS_uc001uoq.1_Missense_Mutation_p.K373N	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	520					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATCAGAGCTCTTTTCCATCT	0.453													0	0	0	0.01441	0	63	112										G	23929191	C	G	23929191	3	3	90	1	0	0	0	0	1	0	0	0	13804	912	32	1	12191	1	SACS	13	23929191	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		23929191	91240687	206	27267										
FREM2	341640	broad.mit.edu	37	chr13	39261881	39261881	+	Frame_Shift_Del	DEL	G	G	-													0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcccgtgcgactttggccctGgcgaggtgcgctactctcac							TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr13:39261881delG	uc001uwv.2	+	1	709	c.400delG	c.(400-402)GGCfs	p.G134fs		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	134	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTTTGGCCCTGGCGAGGTGCG	0.716																		9	17	---	---								-	39261881	G	-	39261881	7	5	90	1	0	1	0	1	0	0	0	0	6045	1348	47	0	402	0	FREM2	13	39261881	Frame_Shift_Del	DEL	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	15332690	39261881	75907997	207	27268										
LAMP1	3916	broad.mit.edu	37	chr13	113975875	113975875	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctctgtgtgtgttgcagaccCtgcctttaaagctgccaacg	10	12	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr13:113975875C>T	uc001vtm.1	+	8	1228	c.947C>T	c.(946-948)CCT>CTT	p.P316L	LAMP1_uc010tka.1_Missense_Mutation_p.P263L	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	316	Lumenal (Potential).|Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GTTGCAGACCCTGCCTTTAAA	0.522													0	0	0	0.01441	0	90	50										T	113975875	C	T	113975875	3	4	90	1	0	0	0	0	1	0	0	0	8617	681	24	2	977	2	LAMP1	13	113975875	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	74713994	113975875	1194003	208	27269										
OSGEP	55644	broad.mit.edu	37	chr14	20916071	20916071	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aataatacatacaccccactCctcccacaatgagggcctcc	4	17	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr14:20916071C>A	uc001vxf.2	-	8	1141	c.785G>T	c.(784-786)GGA>GTA	p.G262V		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	262					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		ACACCCCACTCCTCCCACAAT	0.473													1	0	5.07675e-46	0.01441	5.84216e-46	103	59										A	20916071	C	A	20916071	3	1	90	1	0	0	0	0	1	0	0	0	11287	855	30	3	238	3	OSGEP	14	20916071	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		20916071	86433469	209	27270										
ACIN1	22985	broad.mit.edu	37	chr14	23548812	23548812	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acgtgaccttgatctggactCtgatgttgatctggagccca	11	10	3	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr14:23548812C>G	uc001wit.3	-	6	2234	c.1906G>C	c.(1906-1908)GAG>CAG	p.E636Q	ACIN1_uc001wis.3_Missense_Mutation_p.E318Q|ACIN1_uc010akg.2_Missense_Mutation_p.E636Q|ACIN1_uc010tnj.1_Missense_Mutation_p.E596Q	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	636	Ser-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GATCTGGACTCTGATGTTGAT	0.488													0	0	0	0.01441	0	95	106										G	23548812	C	G	23548812	3	3	90	1	0	0	0	0	1	0	0	0	142	922	32	1	2322	1	ACIN1	14	23548812	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2632741	23548812	83800728	210	27271										
IRF9	10379	broad.mit.edu	37	chr14	24631433	24631433	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggagagtgggcagtttcccgGagtgtgctgggatgatacag	18	6	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr14:24631433G>A	uc001wmq.2	+	2	207	c.80G>A	c.(79-81)GGA>GAA	p.G27E	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_5'Flank	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	27	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		CAGTTTCCCGGAGTGTGCTGG	0.577													0	0	0	0.01441	0	63	76										A	24631433	G	A	24631433	3	1	90	1	0	0	0	0	1	0	0	0	7837	1174	41	1	82	1	IRF9	14	24631433	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1082621	24631433	82718107	211	27272										
AKAP6	9472	broad.mit.edu	37	chr14	33291368	33291368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aaacagtattaccaaacataCccctgactgtttgggagaag	8	9	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr14:33291368C>T	uc001wrq.2	+	13	4519	c.4349C>T	c.(4348-4350)ACC>ATC	p.T1450I		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1450					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ACCAAACATACCCCTGACTGT	0.373													0	0	0	0.007291	0	30	28										T	33291368	C	T	33291368	3	4	90	1	0	0	0	0	1	0	0	0	455	507	18	2	4395	2	AKAP6	14	33291368	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	8659935	33291368	74058172	212	27273										
MAP4K5	11183	broad.mit.edu	37	chr14	50910669	50910669	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atacctacagggaagtctcgTttgtccttttttcgtggtaa	9	8	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr14:50910669T>G	uc001wya.2	-	19	1745	c.1425A>C	c.(1423-1425)AAA>AAC	p.K475N	MAP4K5_uc001wyb.2_Missense_Mutation_p.K475N|MAP4K5_uc010anv.1_Missense_Mutation_p.K475N|MAP4K5_uc001wyc.1_Missense_Mutation_p.K149N	NM_006575	NP_006566	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase	475					activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)					GGAAGTCTCGTTTGTCCTTTT	0.353													0	0	0	0.001168	0	6	7										G	50910669	T	G	50910669	3	3	90	1	0	0	0	0	1	0	0	0	9263	1722	60	5	1171	5	MAP4K5	14	50910669	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	17619301	50910669	56438871	213	27274										
TRIP11	9321	broad.mit.edu	37	chr14	92506013	92506013	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccaatccggagccgaggcccCcaagccaggacgacatcgcg	12	17	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr14:92506013C>G	uc001xzy.2	-	1	805	c.17G>C	c.(16-18)GGG>GCG	p.G6A	TRIP11_uc001xzz.3_RNA	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	6					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GCCGAGGCCCCCAAGCCAGGA	0.577			T	PDGFRB	AML								0	0	0	0.009096	0	4	9										G	92506013	C	G	92506013	3	3	90	1	0	0	0	0	1	0	0	0	16552	623	22	4	6006	4	TRIP11	14	92506013	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	41595344	92506013	14843527	214	27275										
ATP10A	57194	broad.mit.edu	37	chr15	25958905	25958905	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctcatcggtaagcgggtgccGgatcaccactgacatcctct	10	14	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:25958905G>A	uc010ayu.2	-	10	2366	c.2260C>T	c.(2260-2262)CGG>TGG	p.R754W		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	754	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AGCGGGTGCCGGATCACCACT	0.607													0	0	0	0.007291	0	31	65										A	25958905	G	A	25958905	3	1	90	1	0	0	0	0	1	0	0	0	1116	1115	39	2	2287	2	ATP10A	15	25958905	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		25958905	76572487	215	27276										
HERC2	8924	broad.mit.edu	37	chr15	28375401	28375401	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggacctgccgaggccttcgaAcatggtcatctgatccatgg	12	12	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:28375401A>G	uc001zbj.2	-	83	12816	c.12710T>C	c.(12709-12711)GTT>GCT	p.V4237A		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4237	RCC1 18.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGGCCTTCGAACATGGTCATC	0.552													0	0	0	0.01441	0	80	187										G	28375401	A	G	28375401	3	3	90	1	0	0	0	0	1	0	0	0	7058	43	2	5	1838	5	HERC2	15	28375401	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	2416496	28375401	74155991	216	27277										
CASC5	57082	broad.mit.edu	37	chr15	40939188	40939188	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	taatcttttgtatttagaatGagagggagaaacttcaaata	8	3	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:40939188G>A	uc010bbs.1	+	18	6249	c.6088G>A	c.(6088-6090)GAG>AAG	p.E2030K	CASC5_uc010bbt.1_Missense_Mutation_p.E2004K	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	2030	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.|Potential.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TATTTAGAATGAGAGGGAGAA	0.303													0	0	0	0.012319	0	22	27										A	40939188	G	A	40939188	3	1	90	1	0	0	0	0	1	0	0	0	2663	1291	45	1	6154	1	CASC5	15	40939188	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	12563787	40939188	61592204	217	27278										
MAP1A	4130	broad.mit.edu	37	chr15	43815124	43815124	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccaaggtccctggaagagtcAaaatagacaggagccgtgct	12	10	1	2	rs2584715		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:43815124A>C	uc001zrt.2	+	4	1920	c.1453A>C	c.(1453-1455)AAA>CAA	p.K485Q		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	485	Lys-rich (basic).|9 X 3 AA repeats of K-K-[DE].					cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGGAAGAGTCAAAATAGACAG	0.527													0	0	0	0.00308	0	8	33										C	43815124	A	C	43815124	3	2	90	1	0	0	0	0	1	0	0	0	9227	131	5	5	1455	5	MAP1A	15	43815124	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	2875936	43815124	58716268	218	27279			1	121		4	4	1828	N	G_C_A	8.755494e-07
MAP1A	4130	broad.mit.edu	37	chr15	43815610	43815610	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccagagaggaaagtgaacctGaagtaaaggaggatgtgata	14	4	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:43815610G>A	uc001zrt.2	+	4	2406	c.1939G>A	c.(1939-1941)GAA>AAA	p.E647K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	647						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGTGAACCTGAAGTAAAGGA	0.488													0	0	0	0.004007	0	15	27										A	43815610	G	A	43815610	3	1	90	1	0	0	0	0	1	0	0	0	9227	1291	45	1	1941	1	MAP1A	15	43815610	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	486	43815610	58715782	219	27280			1	121		4	4	1828	N	G_C_A	8.755494e-07
MAP1A	4130	broad.mit.edu	37	chr15	43815622	43815622	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtgaacctgaagtaaaggagGatgtgatagaaaaggctgag	15	3	0	5			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:43815622G>A	uc001zrt.2	+	4	2418	c.1951G>A	c.(1951-1953)GAT>AAT	p.D651N		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	651						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGTAAAGGAGGATGTGATAGA	0.473													0	0	0	0.004007	0	15	26										A	43815622	G	A	43815622	3	1	90	1	0	0	0	0	1	0	0	0	9227	1174	41	1	1953	1	MAP1A	15	43815622	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	12	43815622	58715770	220	27281			1	121		4	4	1828	N	G_C_A	8.755494e-07
MAP1A	4130	broad.mit.edu	37	chr15	43816951	43816951	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccattcaactgttgccagcaCaggataaagcaatagtcttt	7	10	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:43816951C>T	uc001zrt.2	+	4	3747	c.3280C>T	c.(3280-3282)CAG>TAG	p.Q1094*		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1094						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GTTGCCAGCACAGGATAAAGC	0.542													0	0	0	0.001168	0	6	161										T	43816951	C	T	43816951	4	4	90	1	0	0	0	0	0	1	0	0	9227	479	17	2	3282	2	MAP1A	15	43816951	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1329	43816951	58714441	221	27282			1	121		4	4	1828	N	G_C_A	8.755494e-07
DUOXA2	405753	broad.mit.edu	37	chr15	45408927	45408927	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctacgcctcggccacgctatGgtaagtgctggagggaaggc	15	11	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:45408927G>A	uc001zuo.2	+	4	834	c.554G>A	c.(553-555)TGG>TAG	p.W185*	DUOX2_uc010bea.2_5'Flank|DUOX2_uc001zun.2_5'Flank|DUOXA2_uc010beb.2_RNA	NM_207581	NP_997464	Q1HG44	DOXA2_HUMAN	dual oxidase activator 2	185	Helical; (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane					0		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		GCCACGCTATGGTAAGTGCTG	0.642													0	0	0	0.010504	0	19	25										A	45408927	G	A	45408927	4	1	90	1	0	0	0	0	0	1	0	0	4803	1362	47	2	568	2	DUOXA2	15	45408927	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1591976	45408927	57122465	222	27283										
LACTB	114294	broad.mit.edu	37	chr15	63433729	63433729	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cagagatgtcttgggataaaGagggtaaatatgcaatggcg	14	4	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:63433729G>A	uc002alw.2	+	6	1408	c.1369G>A	c.(1369-1371)GAG>AAG	p.E457K		NM_032857	NP_116246	P83111	LACTB_HUMAN	lactamase, beta isoform a	457						mitochondrion	hydrolase activity				0						TTGGGATAAAGAGGGTAAATA	0.433													0	0	0	0.007291	0	30	70										A	63433729	G	A	63433729	3	1	90	1	0	0	0	0	1	0	0	0	8597	943	33	1	1395	1	LACTB	15	63433729	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	18024802	63433729	39097663	223	27284										
SCAPER	49855	broad.mit.edu	37	chr15	76958034	76958034	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tatctttttggcttttttttTatttttttgccgctcttctc	4	8	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:76958034T>A	uc002bby.2	-	20	2664	c.2605A>T	c.(2605-2607)AAA>TAA	p.K869*	SCAPER_uc010bkr.2_Nonsense_Mutation_p.K177*|SCAPER_uc002bbx.2_Nonsense_Mutation_p.K623*|SCAPER_uc002bbz.1_Nonsense_Mutation_p.K740*|SCAPER_uc002bca.1_Nonsense_Mutation_p.K734*	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	868						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						GCTTTTTTTTTATTTTTTTGC	0.348													0	0	0	0.009096	0	3	2										A	76958034	T	A	76958034	4	1	90	1	0	0	0	0	0	1	0	0	13878	1763	61	5	1645	5	SCAPER	15	76958034	Nonsense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	13524305	76958034	25573358	224	27285										
ZNF710	374655	broad.mit.edu	37	chr15	90617419	90617419	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgcacgccggcagcaagccCttcaagtgcccctactgctc	9	18	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:90617419C>T	uc002bov.1	+	4	1845	c.1722C>T	c.(1720-1722)CCC>CCT	p.P574P		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	574					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GCAGCAAGCCCTTCAAGTGCC	0.587													0	0	0	0.01441	0	49	29										T	90617419	C	T	90617419	2	4	90	1	0	0	0	0	0	0	0	1	18112	668	24	2		2	ZNF710	15	90617419	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	13659385	90617419	11913973	225	27286										
FES	2242	broad.mit.edu	37	chr15	91428341	91428341	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgcagcaaatgcaggaggcCgagcttcgtctactggaggg	15	10	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:91428341C>T	uc002bpv.2	+	2	162	c.66C>T	c.(64-66)GCC>GCT	p.A22A	FES_uc010uqj.1_Silent_p.A22A|FES_uc010uqk.1_Silent_p.A22A|FES_uc002bpw.2_RNA|FES_uc010bny.2_Silent_p.A22A|FES_uc002bpx.2_Silent_p.A22A|FES_uc002bpy.2_Silent_p.A22A	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	22	FCH.|Important for interaction with membranes containing phosphoinositides.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TGCAGGAGGCCGAGCTTCGTC	0.602													0	0	0	0.01441	0	78	125										T	91428341	C	T	91428341	2	4	90	1	0	0	0	0	0	0	0	1	5820	639	23	2		2	FES	15	91428341	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	810922	91428341	11103051	226	27287										
TTC23	64927	broad.mit.edu	37	chr15	99696485	99696485	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttggcttccagggactctctCaggatcgaggttgctctctg	12	11	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:99696485C>T	uc002bur.2	-	11	1542	c.1011G>A	c.(1009-1011)CTG>CTA	p.L337L	TTC23_uc002bus.2_Silent_p.L337L|TTC23_uc002but.2_Silent_p.L337L|TTC23_uc002buu.2_Silent_p.L337L|TTC23_uc002buv.2_Silent_p.L337L|TTC23_uc002bux.2_Silent_p.L337L|TTC23_uc002buw.2_Silent_p.L337L|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Silent_p.L337L|TTC23_uc010bor.2_Silent_p.L337L|TTC23_uc002buz.2_Silent_p.L337L	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	337							binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			GGGACTCTCTCAGGATCGAGG	0.502													0	0	0	0.01441	0	58	36										T	99696485	C	T	99696485	2	4	90	1	0	0	0	0	0	0	0	1	16687	813	29	1		1	TTC23	15	99696485	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	8268144	99696485	2834907	227	27288										
PCSK6	5046	broad.mit.edu	37	chr15	101938609	101938609	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtagccctggttactcacacCtttttaatgccatactcgaa	6	12	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr15:101938609C>T	uc002bwy.2	-	8	1310	c.996G>A	c.(994-996)AAG>AAA	p.K332K	PCSK6_uc010bpd.2_Silent_p.K202K|PCSK6_uc010bpe.2_Silent_p.K332K|PCSK6_uc002bxa.2_Silent_p.K332K|PCSK6_uc002bxb.2_Silent_p.K332K|PCSK6_uc002bxc.1_Silent_p.K332K|PCSK6_uc002bxd.1_Silent_p.K332K|PCSK6_uc002bxe.2_Silent_p.K332K|PCSK6_uc002bxg.1_Silent_p.K332K	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	332	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTACTCACACCTTTTTAATGC	0.557													0	0	0	0.01441	0	57	147										T	101938609	C	T	101938609	2	4	90	1	0	0	0	0	0	0	0	1	11604	695	24	2		2	PCSK6	15	101938609	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2242124	101938609	592783	228	27289										
SMG1	23049	broad.mit.edu	37	chr16	18856889	18856889	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtttctgcaggagccgctgtGatactcctcacatgctccaa	9	13	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr16:18856889G>A	uc002dfm.2	-	39	6444	c.6081C>T	c.(6079-6081)ATC>ATT	p.I2027I	SMG1_uc010bwb.2_Silent_p.I1887I|SMG1_uc010bwa.2_Silent_p.I758I|SMG1_uc002dfo.3_Silent_p.I325I	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2027					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GAGCCGCTGTGATACTCCTCA	0.433													0	0	0	0.01441	0	85	54										A	18856889	G	A	18856889	2	1	90	1	0	0	0	0	0	0	0	1	14795	1280	45	1		1	SMG1	16	18856889	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		18856889	71497864	229	27290										
TNRC6A	27327	broad.mit.edu	37	chr16	24803020	24803020	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aaatacaactacaaaaatgtGaacatgtggaacaaaaacgt	6	6	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr16:24803020G>A	uc002dmm.2	+	6	3171	c.3057G>A	c.(3055-3057)GTG>GTA	p.V1019V	TNRC6A_uc010bxs.2_Silent_p.V766V|TNRC6A_uc010vcc.1_Silent_p.V766V|TNRC6A_uc002dmn.2_Silent_p.V766V|TNRC6A_uc002dmo.2_Silent_p.V766V	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1019	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ACAAAAATGTGAACATGTGGA	0.468													0	0	0	0.010729	0	11	93										A	24803020	G	A	24803020	2	1	90	1	0	0	0	0	0	0	0	1	16337	1277	45	1		1	TNRC6A	16	24803020	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5946131	24803020	65551733	230	27291										
TGFB1I1	7041	broad.mit.edu	37	chr16	31485480	31485480	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctcctctctccagatgaaatCatgtctcagttcccatctag	5	14	4	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr16:31485480C>A	uc002ecd.1	+	5	359	c.333C>A	c.(331-333)ATC>ATA	p.I111I	TGFB1I1_uc002ece.1_Silent_p.I94I|TGFB1I1_uc010caq.1_Intron	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	111	Transcription activation (By similarity).|Interaction with PTK2 (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						CAGATGAAATCATGTCTCAGT	0.512													1	0	4.74835e-14	0.010818	5.11782e-14	29	24										A	31485480	C	A	31485480	2	1	90	1	0	0	0	0	0	0	0	1	15814	816	29	3		3	TGFB1I1	16	31485480	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	6682460	31485480	58869273	231	27292										
AMFR	267	broad.mit.edu	37	chr16	56436917	56436917	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctggcctccatgtttccaacCacacgtagatagttcttgtg	8	12	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr16:56436917C>T	uc002eiy.2	-	7	1159	c.954G>A	c.(952-954)GTG>GTA	p.V318V	AMFR_uc002eix.2_Nonsense_Mutation_p.W16*	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	318					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						TGTTTCCAACCACACGTAGAT	0.443													0	0	0	0.01441	0	69	99										T	56436917	C	T	56436917	2	4	90	1	0	0	0	0	0	0	0	1	571	581	21	2		2	AMFR	16	56436917	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	24951437	56436917	33917836	232	27293										
CDH8	1006	broad.mit.edu	37	chr16	61747750	61747750	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agctaatatatttaccttcaTttttcttgatggtgaaattc	5	6	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr16:61747750T>C	uc002eog.1	-	10	1901	c.1649A>G	c.(1648-1650)AAT>AGT	p.N550S		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	550	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTTACCTTCATTTTTCTTGAT	0.308													0	0	0	0.00308	0	8	18										C	61747750	T	C	61747750	3	2	90	1	0	0	0	0	1	0	0	0	3116	1493	52	5	762	5	CDH8	16	61747750	Missense_Mutation	SNP	T	TCGA-FJ-A3ZF-01A-11D-A23M-08	5310833	61747750	28607003	233	27294										
ZCCHC14	23174	broad.mit.edu	37	chr16	87493735	87493735	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggggcctcagttcttggagtGatctgagggaacagaaacag	15	7	3	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr16:87493735G>A	uc002fjz.1	-	2	189	c.162C>T	c.(160-162)ATC>ATT	p.I54I	ZCCHC14_uc002fka.1_RNA	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	54					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TTCTTGGAGTGATCTGAGGGA	0.443													0	0	0	0.004482	0	8	153										A	87493735	G	A	87493735	2	1	90	1	0	0	0	0	0	0	0	1	17580	1280	45	1		1	ZCCHC14	16	87493735	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	25745985	87493735	2861018	234	27295										
TP53	7157	broad.mit.edu	37	chr17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttgcggagattctcttcctCtgtgcgccggtctctcccag	10	15	3	1	rs112431538		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	73	2										T	7577085	C	T	7577085	3	4	90	1	0	0	0	0	1	0	0	0	16378	922	32	1	433	1	TP53	17	7577085	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		7577085	73618125	235	27296										
KIAA0100	9703	broad.mit.edu	37	chr17	26958634	26958634	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	catcaggtgaacggtcacctGacttaggtcactcaccatct	8	13	5	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:26958634G>A	uc002hbu.2	-	23	4261	c.4162C>T	c.(4162-4164)CAG>TAG	p.Q1388*		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1388						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					ACGGTCACCTGACTTAGGTCA	0.527													0	0	0	0.00333	0	25	83										A	26958634	G	A	26958634	4	1	90	1	0	0	0	0	0	1	0	0	8154	1299	45	1	2613	1	KIAA0100	17	26958634	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	19381549	26958634	54236576	236	27297										
ATAD5	79915	broad.mit.edu	37	chr17	29161248	29161248	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atcaccactagggaagactaGagacagggtttttgctccac	10	10	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:29161248G>C	uc002hfs.1	+	2	495	c.149G>C	c.(148-150)AGA>ACA	p.R50T	ATAD5_uc002hft.1_5'UTR	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	50					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GGGAAGACTAGAGACAGGGTT	0.368													0	0	0	0.009535	0	31	89										C	29161248	G	C	29161248	3	2	90	1	0	0	0	0	1	0	0	0	1076	942	33	1	155	1	ATAD5	17	29161248	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	2202614	29161248	52033962	237	27298										
MYO1D	4642	broad.mit.edu	37	chr17	31203816	31203816	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctgagcctgaggttggccatGaactcgggcatggagacggt	16	9	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:31203816G>A	uc002hho.1	-	1	87	c.75C>T	c.(73-75)TTC>TTT	p.F25F	MYO1D_uc002hhp.1_Silent_p.F25F|MYO1D_uc010wcb.1_Silent_p.F25F	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	25	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GGTTGGCCATGAACTCGGGCA	0.721													0	0	0	0.004672	0	3	3										A	31203816	G	A	31203816	2	1	90	1	0	0	0	0	0	0	0	1	10071	1281	45	1		1	MYO1D	17	31203816	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	2042568	31203816	49991394	238	27299										
MPP2	4355	broad.mit.edu	37	chr17	41957217	41957217	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccggatggagtcaatacgtGtgccatacaggttgccctcg	12	12	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:41957217G>A	uc010wip.1	-	11	1478	c.1421C>T	c.(1420-1422)ACA>ATA	p.T474I	MPP2_uc002ien.1_Missense_Mutation_p.T446I|MPP2_uc010wim.1_Missense_Mutation_p.T418I|MPP2_uc002ieo.1_Missense_Mutation_p.T429I|MPP2_uc010win.1_Missense_Mutation_p.T290I|MPP2_uc010wio.1_Missense_Mutation_p.T418I	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	453	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GTCAATACGTGTGCCATACAG	0.627											OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	37	78										A	41957217	G	A	41957217	3	1	90	1	0	0	0	0	1	0	0	0	9734	1377	48	2	384	2	MPP2	17	41957217	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10753401	41957217	39237993	239	27300										
COIL	8161	broad.mit.edu	37	chr17	55027348	55027348	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acaggaaacaggatgccctcGtcctcgacctctcccccgca	8	18	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:55027348G>A	uc002iuu.2	-	2	1286	c.1255C>T	c.(1255-1257)CGA>TGA	p.R419*		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	419	3-4.|4 X 2 AA tandem repeats of R-G.|2 X 4 AA repeats of S-L-P-A.					Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					GGATGCCCTCGTCCTCGACCT	0.478													0	0	0	0.01441	0	54	111										A	55027348	G	A	55027348	4	1	90	1	0	0	0	0	0	1	0	0	3665	1153	40	2	499	2	COIL	17	55027348	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	13070131	55027348	26167862	240	27301										
ABCA6	23460	broad.mit.edu	37	chr17	67075206	67075206	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttcctgttctttagaaagctCtaagaatacctaattaggag	7	7	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:67075206C>G	uc002jhw.1	-	39	4937	c.4762G>C	c.(4762-4764)GAG>CAG	p.E1588Q		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1588					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TTAGAAAGCTCTAAGAATACC	0.353													0	0	0	0.010504	0	22	26										G	67075206	C	G	67075206	3	3	90	1	0	0	0	0	1	0	0	0	36	922	32	1	95	1	ABCA6	17	67075206	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	12047858	67075206	14120004	241	27302										
TBC1D16	125058	broad.mit.edu	37	chr17	77922709	77922709	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ggattgtcttccccccggaaGaactggttgttccgatctgt	11	11	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr17:77922709G>T	uc002jxj.2	-	8	1619	c.1503C>A	c.(1501-1503)TTC>TTA	p.F501L	TBC1D16_uc002jxh.2_Missense_Mutation_p.F139L|TBC1D16_uc002jxi.2_Missense_Mutation_p.F126L|TBC1D16_uc002jxk.1_Missense_Mutation_p.F139L	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	501	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			CCCCCCGGAAGAACTGGTTGT	0.572													1	0	4.24508e-63	0.01441	4.96144e-63	102	148										T	77922709	G	T	77922709	3	4	90	1	0	0	0	0	1	0	0	0	15602	933	33	3	820	3	TBC1D16	17	77922709	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10847503	77922709	3272501	242	27303										
PPP4R1	9989	broad.mit.edu	37	chr18	9553378	9553378	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atctgtcaccaaaaactcctGaagttgataaagatattctc	5	9	3	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:9553378G>A	uc002koe.1	-	16	2351	c.2233C>T	c.(2233-2235)CAG>TAG	p.Q745*	PPP4R1_uc002kof.2_Nonsense_Mutation_p.Q162*|PPP4R1_uc010wzo.1_Nonsense_Mutation_p.Q591*|PPP4R1_uc002kod.1_Nonsense_Mutation_p.Q728*	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	745					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						AAAAACTCCTGAAGTTGATAA	0.328													0	0	0	0.012213	0	30	37										A	9553378	G	A	9553378	4	1	90	1	0	0	0	0	0	1	0	0	12403	1299	45	1	639	1	PPP4R1	18	9553378	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		9553378	68523870	243	27304										
PSMA8	143471	broad.mit.edu	37	chr18	23731808	23731808	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tgtggtttttgtgaagttttGacaatttttataggacttac	9	3	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:23731808G>C	uc002kvq.2	+	3	348	c.234G>C	c.(232-234)TTG>TTC	p.L78F	PSMA8_uc002kvo.2_Intron|PSMA8_uc002kvp.2_Intron|PSMA8_uc002kvr.2_Intron	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	78					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			GTGAAGTTTTGACAATTTTTA	0.358													0	0	0	0.01441	0	77	28										C	23731808	G	C	23731808	3	2	90	1	0	0	0	0	1	0	0	0	12673	1281	45	1	244	1	PSMA8	18	23731808	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	14178430	23731808	54345440	244	27305										
ELP2	55250	broad.mit.edu	37	chr18	33744590	33744590	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtttccagagatcgaacctgGtcattgtggaaaaagcagga	12	7	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:33744590G>A	uc002kzk.1	+	18	1924	c.1914G>A	c.(1912-1914)TGG>TGA	p.W638*	ELP2_uc010xcg.1_Nonsense_Mutation_p.W703*|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Nonsense_Mutation_p.W612*|ELP2_uc010xch.1_Nonsense_Mutation_p.W633*|ELP2_uc002kzn.1_Nonsense_Mutation_p.W568*|ELP2_uc002kzo.1_Nonsense_Mutation_p.W568*	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	638	WD 11.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						ATCGAACCTGGTCATTGTGGA	0.398													0	0	0	0.008361	0	29	32										A	33744590	G	A	33744590	4	1	90	1	0	0	0	0	0	1	0	0	5080	1270	44	2	1984	2	ELP2	18	33744590	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	10012782	33744590	44332658	245	27306										
POLI	11201	broad.mit.edu	37	chr18	51804150	51804150	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tggatctaacagaaatggttGagaagagactacagcagctg	12	6	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:51804150G>C	uc002lfj.3	+	4	552	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	POLI_uc010xds.1_Missense_Mutation_p.E162Q|POLI_uc002lfk.3_Missense_Mutation_p.E59Q|POLI_uc002lfl.1_Missense_Mutation_p.E94Q	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	162	UmuC.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		AGAAATGGTTGAGAAGAGACT	0.373								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00245	0	14	17										C	51804150	G	C	51804150	3	2	90	1	0	0	0	0	1	0	0	0	12203	1291	45	1	498	1	POLI	18	51804150	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	18059560	51804150	26273098	246	27307										
ZNF532	55205	broad.mit.edu	37	chr18	56601746	56601746	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gaatccatcagcacaaatctCcctacacctgccctgagtgt	6	15	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:56601746C>A	uc002lho.2	+	5	2975	c.2428C>A	c.(2428-2430)CCC>ACC	p.P810T	ZNF532_uc002lhp.2_Missense_Mutation_p.P808T|ZNF532_uc010xeg.1_Missense_Mutation_p.P808T|ZNF532_uc002lhr.2_Missense_Mutation_p.P808T|ZNF532_uc002lhs.2_Missense_Mutation_p.P808T	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	810					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCACAAATCTCCCTACACCTG	0.522													1	0	1.4709e-25	0.01441	1.64706e-25	59	91										A	56601746	C	A	56601746	3	1	90	1	0	0	0	0	1	0	0	0	17969	855	30	3	2434	3	ZNF532	18	56601746	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	4797596	56601746	21475502	247	27308										
ZNF516	9658	broad.mit.edu	37	chr18	74154543	74154543	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gacccctctgcccccttcttGctgctccgcagcaggactct	8	19	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:74154543G>T	uc010dqx.1	-	2	703	c.468C>A	c.(466-468)AGC>AGA	p.S156R	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CCCCCTTCTTGCTGCTCCGCA	0.701													1	0	0.00024832	0.009096	0.000255142	4	4										T	74154543	G	T	74154543	3	4	90	1	0	0	0	0	1	0	0	0	17957	1310	46	4	3044	4	ZNF516	18	74154543	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	17552797	74154543	3922705	248	27309										
NFATC1	4772	broad.mit.edu	37	chr18	77171093	77171093	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gaagtacagcctcaacggccGgcagccgccctactcacccc	9	19	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr18:77171093G>T	uc010xfg.1	+	2	1271	c.818G>T	c.(817-819)CGG>CTG	p.R273L	NFATC1_uc002lnc.1_Missense_Mutation_p.R273L|NFATC1_uc010xff.1_Missense_Mutation_p.R273L|NFATC1_uc002lnd.2_Missense_Mutation_p.R273L|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.R273L|NFATC1_uc010xfi.1_Missense_Mutation_p.R260L|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.R260L|NFATC1_uc002lng.2_Missense_Mutation_p.R260L|NFATC1_uc010xfk.1_Missense_Mutation_p.R260L	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	273	3 X SP repeats.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CTCAACGGCCGGCAGCCGCCC	0.706													1	0	2.27111e-07	0.013537	2.37926e-07	13	40										T	77171093	G	T	77171093	3	4	90	1	0	0	0	0	1	0	0	0	10361	1116	39	4	916	4	NFATC1	18	77171093	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	3016550	77171093	906155	249	27310										
SEMA6B	10501	broad.mit.edu	37	chr19	4550226	4550226	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cttgacaaagttgaggatgtCatccggcaaggcgctggagg	15	8	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:4550226C>T	uc010duc.1	-	11	1218	c.1180G>A	c.(1180-1182)GAC>AAC	p.D394N	SEMA6B_uc010dud.2_Missense_Mutation_p.D394N|SEMA6B_uc010xih.1_Missense_Mutation_p.D394N	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	394	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGAGGATGTCATCCGGCAAG	0.642													0	0	0	0.007835	0	37	31										T	4550226	C	T	4550226	3	4	90	1	0	0	0	0	1	0	0	0	14040	826	29	1	1510	1	SEMA6B	19	4550226	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		4550226	54578757	250	27311										
ZNF560	147741	broad.mit.edu	37	chr19	9578205	9578205	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttctatcttcaataacacctGaggatgtaccaaaggccttc	6	11	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:9578205G>A	uc002mlp.1	-	10	1628	c.1418C>T	c.(1417-1419)TCA>TTA	p.S473L	ZNF560_uc010dwr.1_Missense_Mutation_p.S367L	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						AATAACACCTGAGGATGTACC	0.393													0	0	0	0.013114	0	45	181										A	9578205	G	A	9578205	3	1	90	1	0	0	0	0	1	0	0	0	17988	1294	45	1	958	1	ZNF560	19	9578205	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5027979	9578205	49550778	251	27312										
ICAM5	7087	broad.mit.edu	37	chr19	10405105	10405105	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gagatggatgaatctacctgCccaagtcaccagacgtggct	11	11	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:10405105C>A	uc002mnu.3	+	9	2084	c.2019C>A	c.(2017-2019)TGC>TGA	p.C673*	ICAM5_uc002mnv.3_Nonsense_Mutation_p.C548*	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	673	Extracellular (Potential).|Ig-like C2-type 8.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			AATCTACCTGCCCAAGTCACC	0.692													1	0	2.14255e-21	0.01441	2.37075e-21	61	34										A	10405105	C	A	10405105	4	1	90	1	0	0	0	0	0	1	0	0	7483	747	26	4	2053	4	ICAM5	19	10405105	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	826900	10405105	48723878	252	27313										
SMARCA4	6597	broad.mit.edu	37	chr19	11152120	11152120	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	agccgcgacaaggacgacgaGagcaagaagcagaagaagcg	15	9	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:11152120G>C	uc002mqf.3	+	30	4592	c.4308G>C	c.(4306-4308)GAG>GAC	p.E1436D	SMARCA4_uc010dxp.2_Missense_Mutation_p.E1436D|SMARCA4_uc010dxo.2_Missense_Mutation_p.E1468D|SMARCA4_uc010dxq.2_Missense_Mutation_p.E1403D|SMARCA4_uc010dxr.2_Missense_Mutation_p.E1403D|SMARCA4_uc002mqj.3_Missense_Mutation_p.E1406D|SMARCA4_uc010dxs.2_Missense_Mutation_p.E1406D|SMARCA4_uc002mqh.3_Missense_Mutation_p.E526D	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1436					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				AGGACGACGAGAGCAAGAAGC	0.617			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.014323	0	22	11										C	11152120	G	C	11152120	3	2	90	1	0	0	0	0	1	0	0	0	14770	933	33	1	4531	1	SMARCA4	19	11152120	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	747015	11152120	47976863	253	27314										
ZNF653	115950	broad.mit.edu	37	chr19	11597944	11597944	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tactggctcctccttctcctCcttctttagcaagcacaggt	6	15	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:11597944C>T	uc002mrz.1	-	5	1254	c.1201G>A	c.(1201-1203)GAG>AAG	p.E401K		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCTTCTCCTCCTTCTTTAGC	0.647													0	0	0	0.01441	0	51	84										T	11597944	C	T	11597944	3	4	90	1	0	0	0	0	1	0	0	0	18063	864	30	1	666	1	ZNF653	19	11597944	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	445824	11597944	47531039	254	27315										
ZNF878	729747	broad.mit.edu	37	chr19	12154731	12154731	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtatgaatcctttcatggtaGagaaaagagttggaagaaat	11	3	1	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:12154731G>A	uc002mta.1	-	5	1626	c.1626C>T	c.(1624-1626)CTC>CTT	p.L542L		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	495	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TTTCATGGTAGAGAAAAGAGT	0.393													0	0	0	0.010504	0	21	39										A	12154731	G	A	12154731	2	1	90	1	0	0	0	0	0	0	0	1	18193	929	33	1		1	ZNF878	19	12154731	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	556787	12154731	46974252	255	27316										
JUNB	3726	broad.mit.edu	37	chr19	12902839	12902839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtctctcaagctcgcctcttCggagctggaacgcctgattg	11	13	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:12902839C>T	uc002mvc.2	+	1	530	c.254C>T	c.(253-255)TCG>TTG	p.S85L	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	85						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						CTCGCCTCTTCGGAGCTGGAA	0.687													0	0	0	0.000602	0	4	21										T	12902839	C	T	12902839	3	4	90	1	0	0	0	0	1	0	0	0	7970	893	31	1	256	1	JUNB	19	12902839	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	748108	12902839	46226144	256	27317										
SYCE2	256126	broad.mit.edu	37	chr19	13015434	13015434	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcttgagtccagagaggagaAgtagagtcccgacttccctt	12	10	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:13015434A>C	uc002mvr.2	-	3	193	c.178T>G	c.(178-180)TTC>GTC	p.F60V		NM_001105578	NP_001099048	Q6PIF2	SYCE2_HUMAN	synaptonemal complex central element protein 2	60					cell division	central element					0						AGAGAGGAGAAGTAGAGTCCC	0.537													0	0	0	0.00308	0	8	196										C	13015434	A	C	13015434	3	2	90	1	0	0	0	0	1	0	0	0	15426	72	3	5	494	5	SYCE2	19	13015434	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	112595	13015434	46113549	257	27318										
TMEM38A	79041	broad.mit.edu	37	chr19	16790904	16790904	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctccttggggagccactgatCgattacttcagcaacaactc	8	13	1	1	rs144587502		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:16790904C>T	uc002nes.2	+	2	325	c.234C>T	c.(232-234)ATC>ATT	p.I78I		NM_024074	NP_076979	Q9H6F2	TM38A_HUMAN	transmembrane protein 38A	78	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			central_nervous_system(2)|ovary(1)	3						AGCCACTGATCGATTACTTCA	0.602													0	0	0	0.013114	0	45	74										T	16790904	C	T	16790904	2	4	90	1	0	0	0	0	0	0	0	1	16156	874	31	1		1	TMEM38A	19	16790904	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3775470	16790904	42338079	258	27319										
PLVAP	83483	broad.mit.edu	37	chr19	17487748	17487748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccggtcaccctggcactggCggaagctggcattgatgcgg	15	13	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:17487748C>T	uc002ngk.1	-	1	400	c.350G>A	c.(349-351)CGC>CAC	p.R117H		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	117	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTGGCACTGGCGGAAGCTGGC	0.428													0	0	0	0.010504	0	19	37										T	17487748	C	T	17487748	3	4	90	1	0	0	0	0	1	0	0	0	12116	768	27	2	1002	2	PLVAP	19	17487748	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	696844	17487748	41641235	259	27320										
SLC27A1	376497	broad.mit.edu	37	chr19	17611152	17611152	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccatccggctggtgaaggtCaatgaggacacaatggagct	13	10	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:17611152C>A	uc002ngu.1	+	8	1322	c.1272C>A	c.(1270-1272)GTC>GTA	p.V424V	SLC27A1_uc010xpp.1_Silent_p.V245V|SLC27A1_uc002ngv.1_Silent_p.V26V	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	424	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						TGGTGAAGGTCAATGAGGACA	0.662													1	0	4.22769e-11	0.00632	4.4792e-11	29	127										A	17611152	C	A	17611152	2	1	90	1	0	0	0	0	0	0	0	1	14525	813	29	3		3	SLC27A1	19	17611152	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	123404	17611152	41517831	260	27321										
SLC27A1	376497	broad.mit.edu	37	chr19	17611371	17611371	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cgccgcttcgatggctatgtCagcgagagcgccaccagcaa	12	14	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:17611371C>G	uc002ngu.1	+	9	1451	c.1401C>G	c.(1399-1401)GTC>GTG	p.V467V	SLC27A1_uc010xpp.1_Silent_p.V288V|SLC27A1_uc002ngv.1_Silent_p.V69V	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	467	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						ATGGCTATGTCAGCGAGAGCG	0.642													0	0	0	0.003163	0	16	37										G	17611371	C	G	17611371	2	3	90	1	0	0	0	0	0	0	0	1	14525	813	29	1		1	SLC27A1	19	17611371	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	219	17611371	41517612	261	27322										
TSHZ3	57616	broad.mit.edu	37	chr19	31768032	31768032	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gactggcggcccttcctcttCtgggcgggcgtcgactcctc	13	16	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:31768032C>T	uc002nsy.3	-	2	2732	c.2667G>A	c.(2665-2667)CAG>CAA	p.Q889Q		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	889					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CCTTCCTCTTCTGGGCGGGCG	0.612													0	0	0	0.01441	0	51	50										T	31768032	C	T	31768032	2	4	90	1	0	0	0	0	0	0	0	1	16622	912	32	1		1	TSHZ3	19	31768032	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	14156661	31768032	27360951	262	27323										
GPI	2821	broad.mit.edu	37	chr19	34884660	34884660	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	caacttcgagcagctgctctCgggggctcactggatggtga	14	11	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:34884660C>T	uc002nvg.1	+	11	996	c.893C>T	c.(892-894)TCG>TTG	p.S298L	GPI_uc002nvf.2_Missense_Mutation_p.S337L|GPI_uc010xrv.1_Missense_Mutation_p.S309L|GPI_uc010xrw.1_Missense_Mutation_p.S270L|GPI_uc010edl.1_Missense_Mutation_p.S298L|GPI_uc002nvi.1_5'UTR	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	298					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					CAGCTGCTCTCGGGGGCTCAC	0.602													0	0	0	0.01441	0	74	92										T	34884660	C	T	34884660	3	4	90	1	0	0	0	0	1	0	0	0	6611	893	31	1	1056	1	GPI	19	34884660	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	3116628	34884660	24244323	263	27324										
C19orf55	148137	broad.mit.edu	37	chr19	36256029	36256029	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atggcctctctcccttctcgGagaccttcatccctgactcc	6	18	3	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:36256029G>A	uc002obq.1	+	7	794	c.721G>A	c.(721-723)GAG>AAG	p.E241K		NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137	241	Ser-rich.									ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCCTTCTCGGAGACCTTCAT	0.478													0	0	0	0.004007	0	16	222										A	36256029	G	A	36256029	3	1	90	1	0	0	0	0	1	0	0	0	1937	1175	41	1	747	1	C19orf55	19	36256029	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1371369	36256029	22872954	264	27325										
RYR1	6261	broad.mit.edu	37	chr19	38945908	38945908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tggtcctgaattgcatagacCgcctaaatgtctacaccact	7	12	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:38945908C>T	uc002oit.2	+	14	1604	c.1474C>T	c.(1474-1476)CGC>TGC	p.R492C	RYR1_uc002oiu.2_Missense_Mutation_p.R492C	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	492	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTGCATAGACCGCCTAAATGT	0.507													0	0	0	0.01441	0	65	105										T	38945908	C	T	38945908	3	4	90	1	0	0	0	0	1	0	0	0	13768	652	23	2	1528	2	RYR1	19	38945908	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2689879	38945908	20183075	265	27326										
PRX	57716	broad.mit.edu	37	chr19	40901226	40901226	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cccttgaacttgaggtcggcCcctgccacctctaccttgcc	8	18	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:40901226C>T	uc002onr.2	-	7	3302	c.3033G>A	c.(3031-3033)GGG>GGA	p.G1011G	PRX_uc002onq.2_Silent_p.G872G|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1011					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAGGTCGGCCCCTGCCACCT	0.647													0	0	0	0.01441	0	72	80										T	40901226	C	T	40901226	2	4	90	1	0	0	0	0	0	0	0	1	12642	610	22	2		2	PRX	19	40901226	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1955318	40901226	18227757	266	27327										
RTN2	6253	broad.mit.edu	37	chr19	45996515	45996515	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acccggaggacaggagtaggGggggtggggcccctttggac	20	9	0	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:45996515G>T	uc002pcb.2	-	5	1164	c.936C>A	c.(934-936)CCC>CCA	p.P312P	RTN2_uc002pcc.2_Intron|RTN2_uc002pcd.2_Intron	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	312						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		CAGGAGTAGGGGGGGTGGGGC	0.562													1	0	5.61819e-17	0.005443	6.12595e-17	28	234										T	45996515	G	T	45996515	2	4	90	1	0	0	0	0	0	0	0	1	13726	1219	43	4		4	RTN2	19	45996515	Silent	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	5095289	45996515	13132468	267	27328										
GRIN2D	2906	broad.mit.edu	37	chr19	48919324	48919324	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aacgaggagcgctccgagatCgtggacttctccgtcccctt	11	14	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:48919324C>T	uc002pjc.3	+	7	1735	c.1647C>T	c.(1645-1647)ATC>ATT	p.I549I		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	549	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GCTCCGAGATCGTGGACTTCT	0.662													0	0	0	0.004289	0	36	118										T	48919324	C	T	48919324	2	4	90	1	0	0	0	0	0	0	0	1	6782	874	31	1		1	GRIN2D	19	48919324	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2922809	48919324	10209659	268	27329										
PPP1R15A	23645	broad.mit.edu	37	chr19	49377076	49377076	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccgtggaggaggaggacgatGaagaagctgtaaagaaagaa	16	4	0	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:49377076G>A	uc002pky.3	+	2	855	c.586G>A	c.(586-588)GAA>AAA	p.E196K		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	196	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GGAGGACGATGAAGAAGCTGT	0.532													0	0	0	0.004482	0	7	129										A	49377076	G	A	49377076	3	1	90	1	0	0	0	0	1	0	0	0	12363	1291	45	1	588	1	PPP1R15A	19	49377076	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	457752	49377076	9751907	269	27330										
NTF4	4909	broad.mit.edu	37	chr19	49564969	49564969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gccactgactgcatcgcacaCagccagctcaccccgacgac	8	19	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:49564969C>T	uc002pmf.3	-	2	427	c.286G>A	c.(286-288)GTG>ATG	p.V96M	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	96					adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GCATCGCACACAGCCAGCTCA	0.701													0	0	0	0.005524	0	38	34										T	49564969	C	T	49564969	3	4	90	1	0	0	0	0	1	0	0	0	10697	478	17	2	350	2	NTF4	19	49564969	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	187893	49564969	9564014	270	27331										
PPFIA3	8541	broad.mit.edu	37	chr19	49643309	49643309	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttggcaagaaagagaagggaCgaatgggacccccaggccgg	16	9	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:49643309C>T	uc002pmr.2	+	18	2664	c.2332C>T	c.(2332-2334)CGA>TGA	p.R778*	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Nonsense_Mutation_p.R646*|PPFIA3_uc002pmt.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	778						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		AGAGAAGGGACGAATGGGACC	0.428													0	0	0	0.01441	0	47	78										T	49643309	C	T	49643309	4	4	90	1	0	0	0	0	0	1	0	0	12311	528	19	2	2398	2	PPFIA3	19	49643309	Nonsense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	78340	49643309	9485674	271	27332										
POLD1	5424	broad.mit.edu	37	chr19	50905324	50905324	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccatcagccgggacagtcgcGgggggagggagctgactggg	20	10	1	1	rs140707092		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:50905324G>T	uc002psb.3	+	5	588	c.532G>T	c.(532-534)GGG>TGG	p.G178W	POLD1_uc002psc.3_Missense_Mutation_p.G178W|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.G178W	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	178					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GGACAGTCGCGGGGGGAGGGA	0.672								DNA_polymerases_(catalytic_subunits)					1	0	8.72198e-27	0.01441	9.79586e-27	49	53										T	50905324	G	T	50905324	3	4	90	1	0	0	0	0	1	0	0	0	12190	1116	39	4	546	4	POLD1	19	50905324	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1262015	50905324	8223659	272	27333										
POLD1	5424	broad.mit.edu	37	chr19	50918133	50918133	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gggcctgctcttctcctcccGgcccgacgcccacgaccgca	10	21	2	0	rs142017093		TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:50918133G>A	uc002psb.3	+	20	2506	c.2450G>A	c.(2449-2451)CGG>CAG	p.R817Q	POLD1_uc002psc.3_Missense_Mutation_p.R817Q|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.R843Q	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	817					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TTCTCCTCCCGGCCCGACGCC	0.667								DNA_polymerases_(catalytic_subunits)			OREG0025635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013114	0	46	49										A	50918133	G	A	50918133	3	1	90	1	0	0	0	0	1	0	0	0	12190	1116	39	2	2524	2	POLD1	19	50918133	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	12809	50918133	8210850	273	27334										
KLK15	55554	broad.mit.edu	37	chr19	51330209	51330209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gccagacaccacacaggcctCccccgggtgggggcaacgcg	14	17	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:51330209C>T	uc002ptl.2	-	3	437	c.406G>A	c.(406-408)GAG>AAG	p.E136K	KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Missense_Mutation_p.E136K|KLK15_uc002pto.2_Missense_Mutation_p.E135K|KLK15_uc010ych.1_Intron|KLK15_uc010yci.1_Missense_Mutation_p.E135K|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	136	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		ACACAGGCCTCCCCCGGGTGG	0.692													0	0	0	0.003163	0	16	97										T	51330209	C	T	51330209	3	4	90	1	0	0	0	0	1	0	0	0	8403	864	30	1	376	1	KLK15	19	51330209	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	412076	51330209	7798774	274	27335										
KLK15	55554	broad.mit.edu	37	chr19	51330397	51330397	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gcttgcgcaggttgtgctctCccaggcgcactctcatgaag	12	13	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:51330397C>T	uc002ptl.2	-	3	249	c.218G>A	c.(217-219)GGA>GAA	p.G73E	KLK15_uc002ptm.2_Missense_Mutation_p.G73E|KLK15_uc002ptn.2_Missense_Mutation_p.G73E|KLK15_uc002pto.2_Missense_Mutation_p.G72E|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Missense_Mutation_p.G72E|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	73	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GTTGTGCTCTCCCAGGCGCAC	0.622													0	0	0	0.008871	0	20	120										T	51330397	C	T	51330397	3	4	90	1	0	0	0	0	1	0	0	0	8403	855	30	1	564	1	KLK15	19	51330397	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	188	51330397	7798586	275	27336										
ZNF614	80110	broad.mit.edu	37	chr19	52519431	52519431	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctttcctgtatgacatctctCatgttgtatgaggcatattt	7	8	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:52519431C>T	uc002pyj.2	-	5	1822	c.1420G>A	c.(1420-1422)GAG>AAG	p.E474K	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Missense_Mutation_p.E177K	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	474	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TGACATCTCTCATGTTGTATG	0.408													0	0	0	0.005443	0	27	291										T	52519431	C	T	52519431	3	4	90	1	0	0	0	0	1	0	0	0	18036	835	29	1	341	1	ZNF614	19	52519431	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	1189034	52519431	6609552	276	27337										
ZNF761	388561	broad.mit.edu	37	chr19	53958557	53958557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gccatcgtagatgtcacactGgtgagaatccttacaagtgt	10	9	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:53958557G>A	uc010eqp.2	+	7	1254	c.796G>A	c.(796-798)GGT>AGT	p.G266S	ZNF761_uc010ydy.1_Missense_Mutation_p.G212S|ZNF761_uc002qbt.1_Missense_Mutation_p.G212S	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ATGTCACACTGGTGAGAATCC	0.413													0	0	0	0.01441	0	146	234										A	53958557	G	A	53958557	3	1	90	1	0	0	0	0	1	0	0	0	18133	1348	47	2	807	2	ZNF761	19	53958557	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1439126	53958557	5170426	277	27338										
NLRP5	126206	broad.mit.edu	37	chr19	56538965	56538965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atcagaagacacaagggttgCgtgcgatcatgaacaaccgt	11	9	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr19:56538965C>T	uc002qmj.2	+	7	1366	c.1366C>T	c.(1366-1368)CGT>TGT	p.R456C	NLRP5_uc002qmi.2_Missense_Mutation_p.R437C	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	456	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ACAAGGGTTGCGTGCGATCAT	0.592													0	0	0	0.00333	0	25	36										T	56538965	C	T	56538965	3	4	90	1	0	0	0	0	1	0	0	0	10480	768	27	2	1392	2	NLRP5	19	56538965	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2580408	56538965	2590018	278	27339										
ISM1	140862	broad.mit.edu	37	chr20	13251266	13251266	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccaacccttccccagaccgcGattccgacaagagacggggc	10	17	0	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:13251266G>T	uc010gce.1	+	2	260	c.254G>T	c.(253-255)CGA>CTA	p.R85L	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	85						extracellular region					0						CCCAGACCGCGATTCCGACAA	0.507													1	0	0.004672	0.004672	0.00474817	3	50										T	13251266	G	T	13251266	3	4	90	1	0	0	0	0	1	0	0	0	7860	1058	37	3	260	3	ISM1	20	13251266	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08		13251266	49774254	279	27340										
KIF16B	55614	broad.mit.edu	37	chr20	16359942	16359942	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gctggcgttctttatattgcAgcctgtactccactggcttt	9	11	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:16359942A>C	uc002wpg.1	-	19	2863	c.2705T>G	c.(2704-2706)CTG>CGG	p.L902R	KIF16B_uc002wpe.1_Missense_Mutation_p.L284R|KIF16B_uc002wpf.1_Missense_Mutation_p.L284R|KIF16B_uc010gch.1_Missense_Mutation_p.L902R|KIF16B_uc010gci.1_Missense_Mutation_p.L902R|KIF16B_uc010gcj.1_Missense_Mutation_p.L913R	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	902	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TTTATATTGCAGCCTGTACTC	0.433													0	0	0	0.01441	0	83	70										C	16359942	A	C	16359942	3	2	90	1	0	0	0	0	1	0	0	0	8278	188	7	5	1280	5	KIF16B	20	16359942	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	3108676	16359942	46665578	280	27341										
CSRP2BP	57325	broad.mit.edu	37	chr20	18142726	18142726	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtgattgacttttcctccttGagctcctctgaccgcacccc	7	16	1	4			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:18142726G>C	uc002wqj.2	+	6	1567	c.945G>C	c.(943-945)TTG>TTC	p.L315F	CSRP2BP_uc002wqk.2_Missense_Mutation_p.L187F|CSRP2BP_uc010zru.1_Missense_Mutation_p.L186F	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	315					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						TTTCCTCCTTGAGCTCCTCTG	0.527													0	0	0	0.01441	0	101	230										C	18142726	G	C	18142726	3	2	90	1	0	0	0	0	1	0	0	0	3968	1281	45	1	963	1	CSRP2BP	20	18142726	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	1782784	18142726	44882794	281	27342										
ITCH	83737	broad.mit.edu	37	chr20	33067581	33067581	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atattttcgttttattggcaGatttattgccatggtaagtg	9	4	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:33067581G>A	uc010geu.1	+	19	2120	c.1928G>A	c.(1927-1929)AGA>AAA	p.R643K	ITCH_uc002xak.2_Missense_Mutation_p.R602K|ITCH_uc010zuj.1_Missense_Mutation_p.R492K	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	643	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TTTATTGGCAGATTTATTGCC	0.368													0	0	0	0.005524	0	38	30										A	33067581	G	A	33067581	3	1	90	1	0	0	0	0	1	0	0	0	7868	942	33	1	1867	1	ITCH	20	33067581	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	14924855	33067581	29957939	282	27343										
CEBPB	1051	broad.mit.edu	37	chr20	48808576	48808576	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	acttgttcaagcagctgcccGagcccctgctcgcctcctcc	8	19	1	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:48808576G>T	uc002xvi.1	+	1	1201	c.1006G>T	c.(1006-1008)GAG>TAG	p.E336*	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	336					acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			GCAGCTGCCCGAGCCCCTGCT	0.488													1	0	3.59834e-05	0.001168	3.70738e-05	6	8										T	48808576	G	T	48808576	4	4	90	1	0	0	0	0	0	1	0	0	3200	1059	37	3	1008	3	CEBPB	20	48808576	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	15740995	48808576	14216944	283	27344										
ZNF217	7764	broad.mit.edu	37	chr20	52199284	52199284	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	catctccatcggactgccaaGagagctgccaatcacttctg	8	14	3	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:52199284G>C	uc002xwq.3	-	1	353	c.82C>G	c.(82-84)CTT>GTT	p.L28V	ZNF217_uc010gij.1_Missense_Mutation_p.L20V	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	28					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GGACTGCCAAGAGAGCTGCCA	0.458													0	0	0	0.00874	0	41	55										C	52199284	G	C	52199284	3	2	90	1	0	0	0	0	1	0	0	0	17769	942	33	1	3080	1	ZNF217	20	52199284	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	3390708	52199284	10826236	284	27345										
C20orf106	200232	broad.mit.edu	37	chr20	55101119	55101119	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aatatggggagaagaaagctCtagctgaatggatttgtgtg	14	3	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr20:55101119C>G	uc002xxx.2	+	2	589	c.509C>G	c.(508-510)TCT>TGT	p.S170C	GCNT7_uc010zzg.1_5'Flank|C20orf107_uc010zzh.1_Intron	NM_001012971	NP_001012989	Q5JX71	CT106_HUMAN	hypothetical protein LOC200232 precursor	170	Cytoplasmic (Potential).					integral to membrane					0			Colorectal(105;0.202)			GAAGAAAGCTCTAGCTGAATG	0.408													0	0	0	0.004656	0	25	50										G	55101119	C	G	55101119	3	3	90	1	0	0	0	0	1	0	0	0	2076	913	32	1	515	1	C20orf106	20	55101119	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	2901835	55101119	7924401	285	27346										
TPTE	7179	broad.mit.edu	37	chr21	10942758	10942758	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	atccatcccttgtgtatcgcCttttgttttctgaaacctga	6	11	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr21:10942758C>T	uc002yip.1	-	13	1051	c.683G>A	c.(682-684)AGG>AAG	p.R228K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.R210K|TPTE_uc002yir.1_Missense_Mutation_p.R190K|TPTE_uc010gkv.1_Missense_Mutation_p.R90K	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	228	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.I228V(1)		ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGTGTATCGCCTTTTGTTTTC	0.328													0	0	0	0.01441	0	90	510										T	10942758	C	T	10942758	3	4	90	1	0	0	0	0	1	0	0	0	16427	681	24	2	1020	2	TPTE	21	10942758	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		10942758	37187137	286	27347										
UBASH3A	53347	broad.mit.edu	37	chr21	43867194	43867194	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccctgggcatgtgcttctgtGaagaaaataaagaggaagga	13	6	1	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr21:43867194G>T	uc002zbe.2	+	15	1912	c.1876G>T	c.(1876-1878)GAA>TAA	p.E626*	UBASH3A_uc002zbf.2_Nonsense_Mutation_p.E588*|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.V515V	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	626	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						GTGCTTCTGTGAAGAAAATAA	0.463													1	0	1.02487e-32	0.01441	1.16152e-32	69	167										T	43867194	G	T	43867194	4	4	90	1	0	0	0	0	0	1	0	0	16836	1291	45	3	1934	3	UBASH3A	21	43867194	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	32924436	43867194	4262701	287	27348										
PRAME	23532	broad.mit.edu	37	chr22	22892514	22892514	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tctttcgcttcactttctcaAtgaggtaggagaacaattca	7	9	4	2	rs140739353	byFrequency	TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr22:22892514A>G	uc002zwf.2	-	4	743	c.587T>C	c.(586-588)ATT>ACT	p.I196T	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.I180T|PRAME_uc010gtr.2_Missense_Mutation_p.I196T|PRAME_uc002zwg.2_Missense_Mutation_p.I196T|PRAME_uc002zwh.2_Missense_Mutation_p.I196T|PRAME_uc002zwi.2_Missense_Mutation_p.I196T|PRAME_uc002zwj.2_Missense_Mutation_p.I196T|PRAME_uc002zwk.2_Missense_Mutation_p.I196T	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	196					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CACTTTCTCAATGAGGTAGGA	0.458													0	0	0	0.01441	0	57	85										G	22892514	A	G	22892514	3	3	90	1	0	0	0	0	1	0	0	0	12424	101	4	5	950	5	PRAME	22	22892514	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08		22892514	28412052	288	27349										
EP300	2033	broad.mit.edu	37	chr22	41553350	41553350	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	aatactgctccaagctctctGaggtctttgaacaagaaatt	7	9	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chr22:41553350G>T	uc003azl.3	+	18	3834	c.3439G>T	c.(3439-3441)GAG>TAG	p.E1147*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1147					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CAAGCTCTCTGAGGTCTTTGA	0.403			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				1	0	1.23713e-20	0.01441	1.36486e-20	48	53										T	41553350	G	T	41553350	4	4	90	1	0	0	0	0	0	1	0	0	5148	1291	45	3	3509	3	EP300	22	41553350	Nonsense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	18660836	41553350	9751216	289	27350										
DHRSX	207063	broad.mit.edu	37	chrX	2209621	2209621	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccggatggaagtcatggaagCcaagtcacagtataaaaatt	10	7	2	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:2209621C>T	uc004cqf.3	-	4	359	c.310G>A	c.(310-312)GCT>ACT	p.A104T		NM_145177	NP_660160	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	104							binding|oxidoreductase activity				0		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GTCATGGAAGCCAAGTCACAG	0.398													0	0	0	0.01441	0	186	150										T	2209621	C	T	2209621	3	4	90	1	0	0	0	0	1	0	0	0	4499	739	26	2	698	2	DHRSX	23	2209621	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		2209621	153060939	290	27351										
STS	412	broad.mit.edu	37	chrX	7175544	7175544	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cgcactggagttttcctcttCacagcctcttcgggaggact	10	13	3	0			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:7175544C>T	uc004cry.3	+	4	557	c.312C>T	c.(310-312)TTC>TTT	p.F104F		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	104	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	TTTTCCTCTTCACAGCCTCTT	0.498									Ichthyosis				0	0	0	0.009096	0	4	69										T	7175544	C	T	7175544	2	4	90	1	0	0	0	0	0	0	0	1	15331	825	29	1		1	STS	23	7175544	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	4965923	7175544	148095016	291	27352										
MOSPD2	158747	broad.mit.edu	37	chrX	14932633	14932633	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtcactccctagcccagcagAagaactgtactttggaagta	9	11	1	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:14932633A>C	uc004cwi.2	+	11	1089	c.1001A>C	c.(1000-1002)GAA>GCA	p.E334A	MOSPD2_uc004cwj.2_Missense_Mutation_p.E271A	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	334	MSP.					integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					AGCCCAGCAGAAGAACTGTAC	0.299													0	0	0	0.013726	0	31	2										C	14932633	A	C	14932633	3	2	90	1	0	0	0	0	1	0	0	0	9716	246	9	5	1043	5	MOSPD2	23	14932633	Missense_Mutation	SNP	A	TCGA-FJ-A3ZF-01A-11D-A23M-08	7757089	14932633	140337927	292	27353										
RNF128	79589	broad.mit.edu	37	chrX	106038818	106038818	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ttctttttaaagatgaaagtCtacagctggtaaaccatgaa	7	6	2	3			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:106038818C>G	uc004eml.2	+	7	1412	c.1162C>G	c.(1162-1164)CTA>GTA	p.L388V	RNF128_uc004emk.2_Missense_Mutation_p.L362V	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	388						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGATGAAAGTCTACAGCTGGT	0.358													0	0	0	0.01441	0	48	54										G	106038818	C	G	106038818	3	3	90	1	0	0	0	0	1	0	0	0	13436	912	32	1	1598	1	RNF128	23	106038818	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	91106185	106038818	49231742	293	27354										
ARHGEF6	9459	broad.mit.edu	37	chrX	135761777	135761777	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ccacggttttataatttgagGaggctccaagggtcctcggg	13	9	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:135761777G>A	uc004fab.2	-	16	2209	c.1747C>T	c.(1747-1749)CCT>TCT	p.P583S	ARHGEF6_uc011mwd.1_Missense_Mutation_p.P456S|ARHGEF6_uc011mwe.1_Missense_Mutation_p.P429S	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	583					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					ATAATTTGAGGAGGCTCCAAG	0.473													0	0	0	0.004482	0	7	143										A	135761777	G	A	135761777	3	1	90	1	0	0	0	0	1	0	0	0	910	1174	41	1	611	1	ARHGEF6	23	135761777	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	29722959	135761777	19508783	294	27355										
SLC6A8	6535	broad.mit.edu	37	chrX	152959662	152959662	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tacttccgtttccaaagggaGatctctgtggccctctgttg	10	11	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:152959662G>T	uc004fib.3	+	9	1610	c.1332G>T	c.(1330-1332)GAG>GAT	p.E444D	SLC6A8_uc004fic.3_Missense_Mutation_p.E434D|SLC6A8_uc011myx.1_Missense_Mutation_p.E329D|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	444	Cytoplasmic (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	TCCAAAGGGAGATCTCTGTGG	0.607													1	0	2.9551e-36	0.01441	3.37984e-36	100	5										T	152959662	G	T	152959662	3	4	90	1	0	0	0	0	1	0	0	0	14690	933	33	3	1366	3	SLC6A8	23	152959662	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	17197885	152959662	2310898	295	27356										
HCFC1	3054	broad.mit.edu	37	chrX	153236183	153236183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	ctccttgatggccacggcgcGgtggccgtggcggggccgtg	19	13	0	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:153236183G>A	uc004fjp.2	-	1	637	c.109C>T	c.(109-111)CGC>TGC	p.R37C	TMEM187_uc004fjq.2_5'Flank	NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	37					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.R37C(1)		ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCACGGCGCGGTGGCCGTGG	0.682													0	0	0	0.004007	0	13	4										A	153236183	G	A	153236183	3	1	90	1	0	0	0	0	1	0	0	0	6991	1116	39	2	6102	2	HCFC1	23	153236183	Missense_Mutation	SNP	G	TCGA-FJ-A3ZF-01A-11D-A23M-08	276521	153236183	2034377	296	27357										
FLNA	2316	broad.mit.edu	37	chrX	153588566	153588566	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	tcggccggaagccccgcctcCgagcagatctcaatggtcag	12	15	2	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:153588566C>T	uc004fkk.2	-	22	3846	c.3597G>A	c.(3595-3597)TCG>TCA	p.S1199S	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Silent_p.S1199S	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1199	Filamin 10.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCCGCCTCCGAGCAGATCT	0.677													0	0	0	0.004007	0	14	40										T	153588566	C	T	153588566	2	4	90	1	0	0	0	0	0	0	0	1	5933	639	23	2		2	FLNA	23	153588566	Silent	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	352383	153588566	1681994	297	27358										
GAB3	139716	broad.mit.edu	37	chrX	153944442	153944442	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	cacgaaattattctgaaattCcttccgaacaaagctggggc	8	10	1	1			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrX:153944442C>G	uc004fmj.1	-	2	283	c.235G>C	c.(235-237)GAA>CAA	p.E79Q	GAB3_uc004fmk.1_Missense_Mutation_p.E79Q|GAB3_uc010nve.1_Missense_Mutation_p.E79Q|GAB3_uc004fml.1_5'UTR	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	79	PH.									ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTCTGAAATTCCTTCCGAACA	0.502													0	0	0	0.01441	0	89	62										G	153944442	C	G	153944442	3	3	90	1	0	0	0	0	1	0	0	0	6150	864	30	1	1564	1	GAB3	23	153944442	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08	355876	153944442	1326118	298	27359										
KDM5D	8284	broad.mit.edu	37	chrY	21878276	21878276	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.361486486486487	107	2.39402152705636e-33	3.54303861122043	4.69369834710744	3.05855030137327	0.0035408128964496	0.0143845523918265	77	gtctctgggaaggcagccatCttgcagatgagctcctcgtg	13	11	2	2			TCGA-FJ-A3ZF-01A-11D-A23M-08	TCGA-FJ-A3ZF-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	55331efe-b1a3-410f-822f-d2512e1768a5	35abd07a-1ed0-4bf2-835d-043a633fcb80	g.chrY:21878276C>G	uc004fug.2	-	15	2208	c.1920G>C	c.(1918-1920)AAG>AAC	p.K640N	KDM5D_uc011naz.1_Missense_Mutation_p.K671N|KDM5D_uc010nwy.2_Missense_Mutation_p.K583N|KDM5D_uc011nba.1_Missense_Mutation_p.K640N|KDM5D_uc004fuf.2_5'Flank	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	640					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	AGGCAGCCATCTTGCAGATGA	0.552													0	0	0	0.01441	0	48	4										G	21878276	C	G	21878276	3	3	90	1	0	0	0	0	1	0	0	0	8136	912	32	1	2751	1	KDM5D	24	21878276	Missense_Mutation	SNP	C	TCGA-FJ-A3ZF-01A-11D-A23M-08		21878276	37495290	299	27360										
AGRN	375790	broad.mit.edu	37	chr1	957650	957650	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gcctgctggacggcggcaacAaggtggtgatcagcggcttt	16	10	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:957650A>G	uc001ack.1	+	2	321	c.271A>G	c.(271-273)AAG>GAG	p.K91E		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	91	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CGGCGGCAACAAGGTGGTGAT	0.602													0	0	0	0.235728	0	37	78										G	957650	A	G	957650	3	3	91	1	0	0	0	0	1	0	0	0	397	131	5	5	277	5	AGRN	1	957650	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08		957650	248292971	1	27361										
GJB4	127534	broad.mit.edu	37	chr1	35227230	35227230	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aacctgagcaagaagcggggCggactgtggtggacgtactt	16	8	0	2	rs147830069		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:35227230C>T	uc001bxv.1	+	2	745	c.375C>T	c.(373-375)GGC>GGT	p.G125G	GJB4_uc001bxw.3_Silent_p.G125G	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	125	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				AGAAGCGGGGCGGACTGTGGT	0.592													0	0	0	0.132662	0	14	28										T	35227230	C	T	35227230	2	4	91	1	0	0	0	0	0	0	0	1	6410	755	27	2		2	GJB4	1	35227230	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	34269580	35227230	214023391	2	27362										
OXCT2	64064	broad.mit.edu	37	chr1	40236123	40236123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gtatttctgcccctttatcaCgcgatctacataaatgttag	6	10	3	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:40236123C>T	uc001ceb.1	-	1	898	c.805G>A	c.(805-807)GTG>ATG	p.V269M	BMP8B_uc001cdz.1_Intron|BMP8B_uc001cea.1_Intron|OXCT2_uc009vvu.1_Missense_Mutation_p.V263M	NM_022120	NP_071403	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2 precursor	269					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			pancreas(1)	1	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	CCCTTTATCACGCGATCTACA	0.532											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.234183	0	22	107										T	40236123	C	T	40236123	3	4	91	1	0	0	0	0	1	0	0	0	11330	536	19	2	752	2	OXCT2	1	40236123	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	5008893	40236123	209014498	3	27363										
PRPF38B	55119	broad.mit.edu	37	chr1	109242068	109242068	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aagggacagggatcgagaaaGagagaaagaaaatgagagag	16	2	0	6			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:109242068G>A	uc001dvv.3	+	6	1349	c.1067G>A	c.(1066-1068)AGA>AAA	p.R356K	PRPF38B_uc001dvw.3_Missense_Mutation_p.R245K|PRPF38B_uc010ouz.1_Missense_Mutation_p.R159K	NM_018061	NP_060531	Q5VTL8	PR38B_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	356	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex					0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		gatcgagaaagagagaaagaa	0.219													0	0	0	0.038147	0	8	26										A	109242068	G	A	109242068	3	1	91	1	0	0	0	0	1	0	0	0	12568	942	33	1	1089	1	PRPF38B	1	109242068	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	69005945	109242068	140008553	4	27364										
RSBN1	54665	broad.mit.edu	37	chr1	114340631	114340631	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agacaaaatcatcggctctcTgggttttaccattttcatct	6	10	4	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:114340631T>C	uc001edq.2	-	2	767	c.731A>G	c.(730-732)CAG>CGG	p.Q244R	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	244						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCGGCTCTCTGGGTTTTACC	0.358													0	0	0	0.11126	0	44	71										C	114340631	T	C	114340631	3	2	91	1	0	0	0	0	1	0	0	0	13696	1580	55	5	1701	5	RSBN1	1	114340631	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	5098563	114340631	134909990	5	27365										
ADAM30	11085	broad.mit.edu	37	chr1	120438648	120438648	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ttgcagtcctttggtatgtaAggatgatcctccagcagttc	10	9	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:120438648A>T	uc001eij.2	-	1	466	c.312T>A	c.(310-312)CCT>CCA	p.P104P		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	104					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.P104L(1)		ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TTGGTATGTAAGGATGATCCT	0.502													0	0	0	0.153744	0	33	35										T	120438648	A	T	120438648	2	4	91	1	0	0	0	0	0	0	0	1	248	59	3	5		5	ADAM30	1	120438648	Silent	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	6098017	120438648	128811973	6	27366										
PDE4DIP	9659	broad.mit.edu	37	chr1	144922560	144922560	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agtttccttgaggttctgaaTtgtaccatcttgcttttgag	9	7	2	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:144922560T>C	uc001elw.3	-	7	1138	c.847A>G	c.(847-849)ATT>GTT	p.I283V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.I349V|PDE4DIP_uc001emc.1_Missense_Mutation_p.I283V|PDE4DIP_uc001emd.1_Missense_Mutation_p.I283V|PDE4DIP_uc001emb.1_Missense_Mutation_p.I446V|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.I70V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	283	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGGTTCTGAATTGTACCATCT	0.388			T	PDGFRB	MPD								0	0	0	0.139131	0	48	383										C	144922560	T	C	144922560	3	2	91	1	0	0	0	0	1	0	0	0	11643	1493	52	5	6355	5	PDE4DIP	1	144922560	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	24483912	144922560	104328061	7	27367										
S100A5	6276	broad.mit.edu	37	chr1	153509783	153509783	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cagccctggtcacttgttgtCctctagaaagaagtcgttgt	10	10	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:153509783C>T	uc001fbx.2	-	4	550	c.322G>A	c.(322-324)GAC>AAC	p.D108N	S100A6_uc001fbw.1_5'Flank	NM_002962	NP_002953	P33763	S10A5_HUMAN	S100 calcium binding protein A5	90						nucleus	calcium ion binding|copper ion binding|protein homodimerization activity|zinc ion binding				0	all_lung(78;5.98e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACTTGTTGTCCTCTAGAAAG	0.582													0	0	0	0.134883	0	31	33										T	153509783	C	T	153509783	3	4	91	1	0	0	0	0	1	0	0	0	13781	855	30	1	14	1	S100A5	1	153509783	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	8587223	153509783	95740838	8	27368										
ATF6	22926	broad.mit.edu	37	chr1	161771931	161771931	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agccagtccttgctgttgctGggggagtcacacagctccct	12	13	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:161771931G>A	uc001gbr.2	+	7	845	c.778G>A	c.(778-780)GGG>AGG	p.G260R	ATF6_uc001gbq.1_Missense_Mutation_p.G260R	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	260	Cytoplasmic (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TGCTGTTGCTGGGGGAGTCAC	0.532													0	0	0	0.108266	0	23	71										A	161771931	G	A	161771931	3	1	91	1	0	0	0	0	1	0	0	0	1084	1348	47	2	804	2	ATF6	1	161771931	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	8262148	161771931	87478690	9	27369										
VAMP4	8674	broad.mit.edu	37	chr1	171707494	171707494	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agattccgaacttaccctttCacttttcacagaacctgtga	5	12	2	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:171707494C>T	uc001ghx.1	-	2	275	c.61G>A	c.(61-63)GAA>AAA	p.E21K	VAMP4_uc001ghw.1_RNA|VAMP4_uc001ghy.1_Missense_Mutation_p.E21K	NM_003762	NP_003753	O75379	VAMP4_HUMAN	vesicle-associated membrane protein 4	21	Cytoplasmic (Potential).				vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome					0	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTTACCCTTTCACTTTTCACA	0.318													0	0	0	0.038147	0	6	27										T	171707494	C	T	171707494	3	4	91	1	0	0	0	0	1	0	0	0	17112	835	29	1	392	1	VAMP4	1	171707494	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	9935563	171707494	77543127	10	27370										
LOC642587	642587	broad.mit.edu	37	chr1	209602671	209602671	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tttcattaaagagagaaatcAactattcaggaccggccccc	7	11	3	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:209602671A>T	uc009xcn.2	+	2	412	c.29A>T	c.(28-30)CAA>CTA	p.Q10L	LOC642587_uc010psk.1_5'Flank|MIR205_hsa-mir-205|MI0000285_5'Flank	NM_001104548	NP_001098018			hypothetical protein LOC642587												0				OV - Ovarian serous cystadenocarcinoma(81;0.0422)		GAGAGAAATCAACTATTCAGG	0.284													0	0	0	0.115264	0	2	4										T	209602671	A	T	209602671	3	4	91	1	0	0	0	0	1	0	0	0	8882	130	5	5	31	5	LOC642587	1	209602671	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	37895177	209602671	39647950	11	27371										
DISP1	84976	broad.mit.edu	37	chr1	223116445	223116445	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	accatcaccctttgactagcCatagcagtcaccaagagtgc	7	14	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:223116445C>T	uc001hnu.1	+	2	427	c.280C>T	c.(280-282)CAT>TAT	p.H94Y		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	94					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		TTTGACTAGCCATAGCAGTCA	0.532													0	0	0	0.144211	0	29	94										T	223116445	C	T	223116445	3	4	91	1	0	0	0	0	1	0	0	0	4539	594	21	2	282	2	DISP1	1	223116445	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	13513774	223116445	26134176	12	27372										
LYST	1130	broad.mit.edu	37	chr1	235884187	235884187	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gttatttgtgagtatattgtGgtatacatcatcacgaacct	8	6	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:235884187G>C	uc001hxj.2	-	40	9509	c.9334C>G	c.(9334-9336)CAC>GAC	p.H3112D	LYST_uc001hxi.2_Missense_Mutation_p.H336D	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3112					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AGTATATTGTGGTATACATCA	0.338									Chediak-Higashi_syndrome				0	0	0	0.219247	0	21	91										C	235884187	G	C	235884187	3	2	91	1	0	0	0	0	1	0	0	0	9128	1348	47	4	2127	4	LYST	1	235884187	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	12767742	235884187	13366434	13	27373										
AHCTF1	25909	broad.mit.edu	37	chr1	247025300	247025300	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggacatcttcttccacaaaTgaaattctagtttctttaag	5	8	4	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr1:247025300T>A	uc001ibu.1	-	27	3703	c.3696A>T	c.(3694-3696)TCA>TCT	p.S1232S	AHCTF1_uc001ibv.1_Silent_p.S1241S|AHCTF1_uc009xgs.1_Silent_p.S93S|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1232	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTTCCACAAATGAAATTCTAG	0.398													0	0	0	0.234183	0	21	21										A	247025300	T	A	247025300	2	1	91	1	0	0	0	0	0	0	0	1	408	1451	51	5		5	AHCTF1	1	247025300	Silent	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	11141113	247025300	2225321	14	27374										
ALLC	55821	broad.mit.edu	37	chr2	3750104	3750104	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	catctgcctcctgaggccccGggagaagcccatgttgaagt	12	13	1	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:3750104G>A	uc010ewt.2	+	12	1288	c.1127G>A	c.(1126-1128)CGG>CAG	p.R376Q	ALLC_uc002qyf.2_Missense_Mutation_p.R147Q	NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	395							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		CTGAGGCCCCGGGAGAAGCCC	0.597										HNSCC(21;0.051)			0	0	0	0.09319	0	12	27										A	3750104	G	A	3750104	3	1	91	1	0	0	0	0	1	0	0	0	534	1116	39	2	1169	2	ALLC	2	3750104	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		3750104	239449269	15	27375										
C2orf39	92749	broad.mit.edu	37	chr2	26624885	26624885	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgccggggtccctagaggccCtggacccgaacgtggacgag	16	14	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:26624885C>T	uc002rhg.2	+	1	102	c.28C>T	c.(28-30)CTG>TTG	p.L10L	C2orf39_uc010eym.1_RNA	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	10											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTAGAGGCCCTGGACCCGAA	0.657													0	0	0	0.038147	0	7	19										T	26624885	C	T	26624885	2	4	91	1	0	0	0	0	0	0	0	1	2164	680	24	2		2	C2orf39	2	26624885	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	22874781	26624885	216574488	16	27376										
VIT	5212	broad.mit.edu	37	chr2	37032673	37032673	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggtggtggtgatggtggatGgctggcccacggacaaagtg	19	6	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:37032673G>T	uc002rpl.2	+	14	1476	c.1255G>T	c.(1255-1257)GGC>TGC	p.G419C	VIT_uc002rpm.2_Missense_Mutation_p.G397C|VIT_uc010ezv.2_Missense_Mutation_p.G375C|VIT_uc010ezw.2_Missense_Mutation_p.G376C	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	404	VWFA 1.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				GATGGTGGATGGCTGGCCCAC	0.502													1	0	2.39556e-15	0.26419	2.6494e-15	23	106										T	37032673	G	T	37032673	3	4	91	1	0	0	0	0	1	0	0	0	17168	1348	47	4	1430	4	VIT	2	37032673	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	10407788	37032673	206166700	17	27377										
MPHOSPH10	10199	broad.mit.edu	37	chr2	71368431	71368431	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aatataaaaagcgtttaaccTtagaccatgagaagagtaaa	7	5	0	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:71368431T>A	uc002sht.1	+	7	1730	c.1378T>A	c.(1378-1380)TTA>ATA	p.L460I		NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	460					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GCGTTTAACCTTAGACCATGA	0.378													0	0	0	0.139131	0	89	180										A	71368431	T	A	71368431	3	1	91	1	0	0	0	0	1	0	0	0	9725	1606	56	5	1404	5	MPHOSPH10	2	71368431	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	34335758	71368431	171830942	18	27378										
FAHD2A	51011	broad.mit.edu	37	chr2	96072867	96072867	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agtttgccagctccatcgtgGggccctatgatgaggtggtc	14	10	0	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:96072867G>C	uc002sur.2	+	3	603	c.424G>C	c.(424-426)GGG>CGG	p.G142R	FAHD2A_uc002sus.2_Missense_Mutation_p.G142R	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	142							hydrolase activity|metal ion binding			ovary(1)	1						CTCCATCGTGGGGCCCTATGA	0.577													0	0	0	0.153744	0	32	45										C	96072867	G	C	96072867	3	2	91	1	0	0	0	0	1	0	0	0	5373	1232	43	4	430	4	FAHD2A	2	96072867	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	24704436	96072867	147126506	19	27379										
GLI2	2736	broad.mit.edu	37	chr2	121747297	121747297	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ctcaaccagttcccccaatcCtgcagcaacatgccagccaa	5	18	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:121747297C>T	uc010flp.2	+	13	3837	c.3807C>T	c.(3805-3807)TCC>TCT	p.S1269S	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.S941S|GLI2_uc002tmu.3_Silent_p.S924S	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1269					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				TCCCCCAATCCTGCAGCAACA	0.622													0	0	0	0.083992	0	24	15										T	121747297	C	T	121747297	2	4	91	1	0	0	0	0	0	0	0	1	6438	668	24	2		2	GLI2	2	121747297	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	25674430	121747297	121452076	20	27380										
CCDC74B	91409	broad.mit.edu	37	chr2	130897506	130897506	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggagaccttggggaaatgcGtggcttcttggtccctgggt	16	8	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:130897506G>A	uc002tqm.1	-	7	1027	c.965C>T	c.(964-966)ACG>ATG	p.T322M	CCDC74B_uc010yzw.1_Missense_Mutation_p.T424M|CCDC74B_uc002tqn.1_Missense_Mutation_p.T256M	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	322											0	Colorectal(110;0.1)					GGGGAAATGCGTGGCTTCTTG	0.627													0	0	0	0.249174	0	20	42										A	130897506	G	A	130897506	3	1	91	1	0	0	0	0	1	0	0	0	2848	1145	40	2	185	2	CCDC74B	2	130897506	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	9150209	130897506	112301867	21	27381										
ZDBF2	57683	broad.mit.edu	37	chr2	207169788	207169789	+	Frame_Shift_Ins	INS	-	-	C													0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aatagaagcaacttggtacgINSccccccagtgatttgtaatg							TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:207169788_207169789insC	uc002vbp.2	+	5	786_787	c.536_537insC	c.(535-537)CGCfs	p.R179fs		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	179							nucleic acid binding|zinc ion binding			ovary(3)	3						AACTTGGTACGCCCCCCAGTGA	0.426																		18	24	---	---								C	207169789	-	C	207169788	7	5	91	1	0	1	1	0	0	0	0	0	17596	1087	38	0	546	0	ZDBF2	2	207169788	Frame_Shift_Ins	INS	-	TCGA-FT-A3EE-01A-11D-A202-08	76272282	207169788	36029585	22	27382										
RHBDD1	84236	broad.mit.edu	37	chr2	227779059	227779059	+	Frame_Shift_Del	DEL	G	G	-													0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agcattacaagccagcctctGggaccgaggtaggagtcttg							TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:227779059delG	uc002voi.2	+	6	969	c.848delG	c.(847-849)TGGfs	p.W283fs	RHBDD1_uc010fxc.2_Frame_Shift_Del_p.W283fs|RHBDD1_uc002voj.2_Frame_Shift_Del_p.W114fs	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	283						integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		GCCAGCCTCTGGGACCGAGGT	0.443																		21	24	---	---								-	227779059	G	-	227779059	7	5	91	1	0	1	0	1	0	0	0	0	13316	1357	47	0	866	0	RHBDD1	2	227779059	Frame_Shift_Del	DEL	G	TCGA-FT-A3EE-01A-11D-A202-08	20609271	227779059	15420314	23	27383										
RBM44	375316	broad.mit.edu	37	chr2	238726589	238726589	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	atgaaggtaaagatttttgtGgaaataaaattgttgagaac	10	1	0	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr2:238726589G>A	uc002vxi.3	+	3	1162	c.1030G>A	c.(1030-1032)GGA>AGA	p.G344R		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	343							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		AGATTTTTGTGGAAATAAAAT	0.308													0	0	0	0.116897	0	28	20										A	238726589	G	A	238726589	3	1	91	1	0	0	0	0	1	0	0	0	13138	1349	47	2	1036	2	RBM44	2	238726589	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	10947530	238726589	4472784	24	27384										
LRRN1	57633	broad.mit.edu	37	chr3	3886952	3886952	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gtgattggaattctggatatGaacttcaaacccctcgcaaa	8	9	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:3886952G>A	uc003bpt.3	+	2	1388	c.627G>A	c.(625-627)ATG>ATA	p.M209I	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	209	Extracellular (Potential).|LRR 6.					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTCTGGATATGAACTTCAAAC	0.413													0	0	0	0.139131	0	89	158										A	3886952	G	A	3886952	3	1	91	1	0	0	0	0	1	0	0	0	9034	1290	45	1	629	1	LRRN1	3	3886952	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		3886952	194135478	25	27385										
DCLK3	85443	broad.mit.edu	37	chr3	36779198	36779198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gctccttttctagctttgcaGgttggtcatctctgagagtc	10	10	3	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:36779198G>A	uc003cgi.2	-	2	1444	c.953C>T	c.(952-954)CCT>CTT	p.P318L		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	318						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						TAGCTTTGCAGGTTGGTCATC	0.567													0	0	0	0.139131	0	53	131										A	36779198	G	A	36779198	3	1	91	1	0	0	0	0	1	0	0	0	4293	1000	35	2	1009	2	DCLK3	3	36779198	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	32892246	36779198	161243232	26	27386										
ZNF502	91392	broad.mit.edu	37	chr3	44762896	44762896	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gaaagcctttagtcgtagttCattccttgttcaacatcaaa	6	9	3	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:44762896C>T	uc011baa.1	+	4	842	c.587C>T	c.(586-588)TCA>TTA	p.S196L	ZNF502_uc003cns.2_Missense_Mutation_p.S196L|ZNF502_uc011bab.1_Missense_Mutation_p.S196L|ZNF502_uc003cnt.2_Missense_Mutation_p.S196L	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	196	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGTCGTAGTTCATTCCTTGTT	0.428													0	0	0	0.139131	0	70	159										T	44762896	C	T	44762896	3	4	91	1	0	0	0	0	1	0	0	0	17947	838	29	1	593	1	ZNF502	3	44762896	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	7983698	44762896	153259534	27	27387										
CDC25A	993	broad.mit.edu	37	chr3	48224431	48224431	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	acactcacattttccttgttCtcatctgggtcgatgagctg	8	11	3	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:48224431C>A	uc003csh.1	-	5	781	c.417G>T	c.(415-417)GAG>GAT	p.E139D	CDC25A_uc003csi.1_Missense_Mutation_p.E139D	NM_001789	NP_001780	P30304	MPIP1_HUMAN	cell division cycle 25A isoform a	139					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|kidney(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TTTCCTTGTTCTCATCTGGGT	0.483													1	0	3.73148e-12	0.125774	4.09971e-12	29	61										A	48224431	C	A	48224431	3	1	91	1	0	0	0	0	1	0	0	0	3062	912	32	3	1201	3	CDC25A	3	48224431	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	3461535	48224431	149797999	28	27388										
CELSR3	1951	broad.mit.edu	37	chr3	48682555	48682555	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gcgtggctcaacctgcatgcGgtagaggtgcagcccctgca	14	13	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:48682555G>A	uc003cul.2	-	25	8166	c.7885C>T	c.(7885-7887)CGC>TGC	p.R2629C	CELSR3_uc003cuf.1_Missense_Mutation_p.R2726C|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.R612C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2629	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACCTGCATGCGGTAGAGGTGC	0.657													0	0	0	0.146539	0	14	22										A	48682555	G	A	48682555	3	1	91	1	0	0	0	0	1	0	0	0	3223	1116	39	2	2097	2	CELSR3	3	48682555	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	458124	48682555	149339875	29	27389										
C3orf63	23272	broad.mit.edu	37	chr3	56662575	56662575	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	taataatcaatagtttatctAattttgatcttctttccaaa	2	6	4	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:56662575A>G	uc003did.3	-	18	3733	c.3632T>C	c.(3631-3633)TTA>TCA	p.L1211S	C3orf63_uc003dib.3_Missense_Mutation_p.L330S|C3orf63_uc003dic.3_Missense_Mutation_p.L835S|C3orf63_uc003die.3_Missense_Mutation_p.L1272S	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1272										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		TAGTTTATCTAATTTTGATCT	0.274													0	0	0	0.132662	0	16	41										G	56662575	A	G	56662575	3	3	91	1	0	0	0	0	1	0	0	0	2239	372	13	5	1281	5	C3orf63	3	56662575	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	7980020	56662575	141359855	30	27390										
ATP13A3	79572	broad.mit.edu	37	chr3	194174455	194174455	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cttcatttactctacaaactGaaactcttacggtactatga	4	10	3	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:194174455G>A	uc003fty.3	-	9	1220	c.818C>T	c.(817-819)TCA>TTA	p.S273L	ATP13A3_uc003ftz.1_5'Flank	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	273					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TCTACAAACTGAAACTCTTAC	0.348													0	0	0	0.204396	0	19	24										A	194174455	G	A	194174455	3	1	91	1	0	0	0	0	1	0	0	0	1125	1294	45	1	2958	1	ATP13A3	3	194174455	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	137511880	194174455	3847975	31	27391										
TNK2	10188	broad.mit.edu	37	chr3	195599181	195599181	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgggaagccccagcagtggcGggggtcactgtcgccatgcc	16	14	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:195599181G>C	uc003fvu.1	-	10	1960	c.1417C>G	c.(1417-1419)CGC>GGC	p.R473G	TNK2_uc003fvq.1_5'Flank|TNK2_uc003fvr.1_5'UTR|TNK2_uc003fvs.1_Missense_Mutation_p.R505G|TNK2_uc003fvt.1_Missense_Mutation_p.R536G|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Missense_Mutation_p.R303G	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	473				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CAGCAGTGGCGGGGGTCACTG	0.677													0	0	0	0.038147	0	8	18										C	195599181	G	C	195599181	3	2	91	1	0	0	0	0	1	0	0	0	16315	1116	39	4	1772	4	TNK2	3	195599181	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	1424726	195599181	2423249	32	27392										
PAK2	5062	broad.mit.edu	37	chr3	196530009	196530009	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgactccaacacagtgaagcAgaaatatctgagctttactc	7	11	1	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:196530009A>C	uc003fwy.3	+	4	732	c.410A>C	c.(409-411)CAG>CCG	p.Q137P		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	137	Autoregulatory region (By similarity).				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		ACAGTGAAGCAGAAATATCTG	0.428													0	0	0	0.203993	0	36	19										C	196530009	A	C	196530009	3	2	91	1	0	0	0	0	1	0	0	0	11401	188	7	5	420	5	PAK2	3	196530009	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	930828	196530009	1492421	33	27393										
LMLN	89782	broad.mit.edu	37	chr3	197712742	197712742	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cttcaagatttgcagatggcCtcccaccttttaattatagg	7	10	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr3:197712742C>T	uc011buo.1	+	8	932	c.910C>T	c.(910-912)CTC>TTC	p.L304F	LMLN_uc003fyt.2_Missense_Mutation_p.L252F|LMLN_uc010iar.2_Missense_Mutation_p.L304F|LMLN_uc010ias.2_Missense_Mutation_p.L252F|LMLN_uc003fyu.2_Missense_Mutation_p.L64F	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	304					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		TGCAGATGGCCTCCCACCTTT	0.378													0	0	0	0.189662	0	17	10										T	197712742	C	T	197712742	3	4	91	1	0	0	0	0	1	0	0	0	8847	681	24	2	940	2	LMLN	3	197712742	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	1182733	197712742	309688	34	27394										
ACOX3	8310	broad.mit.edu	37	chr4	8412072	8412072	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cttcgaaatcaggggaatgtAtgatgaattcctgcacaagg	11	7	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:8412072A>G	uc010idk.2	-	6	699	c.554T>C	c.(553-555)ATA>ACA	p.I185T	ACOX3_uc003glc.3_Missense_Mutation_p.I185T|ACOX3_uc003gld.3_Missense_Mutation_p.I185T|ACOX3_uc003gle.1_Missense_Mutation_p.I90T	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	185					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AGGGGAATGTATGATGAATTC	0.438													0	0	0	0.116897	0	27	16										G	8412072	A	G	8412072	3	3	91	1	0	0	0	0	1	0	0	0	160	449	16	5	1600	5	ACOX3	4	8412072	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08		8412072	182742204	35	27395										
C4orf14	84273	broad.mit.edu	37	chr4	57842668	57842668	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gcccttggcagtgcagtaatCggactccaggagcgtgttaa	13	10	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:57842668C>T	uc003hck.2	-	1	1159	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	362							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					GTGCAGTAATCGGACTCCAGG	0.607													0	0	0	0.105934	0	14	14										T	57842668	C	T	57842668	3	4	91	1	0	0	0	0	1	0	0	0	2251	884	31	1	1040	1	C4orf14	4	57842668	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	49430596	57842668	133311608	36	27396										
HSD17B11	51170	broad.mit.edu	37	chr4	88312220	88312220	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aggatgtccagaagaaatttCatcccttttgtggctgcgag	11	8	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr4:88312220C>T	uc003hqp.2	-	1	236	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	1					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		GAAGAAATTTCATCCCTTTTG	0.428													0	0	0	0.09319	0	13	9										T	88312220	C	T	88312220	3	4	91	1	0	0	0	0	1	0	0	0	7380	826	29	1	927	1	HSD17B11	4	88312220	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	30469552	88312220	102842056	37	27397										
SDHA	6389	broad.mit.edu	37	chr5	236602	236602	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ggcctgtacgcctgtggggaGgccgcctgtgcctcggtaca	16	13	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:236602G>A	uc003jao.3	+	10	1435	c.1320G>A	c.(1318-1320)GAG>GAA	p.E440E	SDHA_uc011clv.1_Silent_p.E440E|SDHA_uc011clw.1_Silent_p.E392E|SDHA_uc003jap.3_Silent_p.E440E|SDHA_uc003jaq.3_Silent_p.E215E|SDHA_uc003jar.3_Silent_p.E34E	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	440		FAD (By similarity).			nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCTGTGGGGAGGCCGCCTGTG	0.592									Familial_Paragangliomas				0	0	0	0.189662	0	20	47										A	236602	G	A	236602	2	1	91	1	0	0	0	0	0	0	0	1	13963	991	35	2		2	SDHA	5	236602	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		236602	180678658	38	27398										
SLC6A3	6531	broad.mit.edu	37	chr5	1406324	1406324	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aggagaaagcaggggctgacCagcttccagcacagccgcca	13	13	0	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:1406324C>A	uc003jck.2	-	12	1699	c.1578G>T	c.(1576-1578)CTG>CTT	p.L526L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	526	Helical; Name=11; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGGGGCTGACCAGCTTCCAGC	0.672													1	0	2.42023e-17	0.183431	2.73094e-17	36	52										A	1406324	C	A	1406324	2	1	91	1	0	0	0	0	0	0	0	1	14685	581	21	4		4	SLC6A3	5	1406324	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	1169722	1406324	179508936	39	27399										
GDNF	2668	broad.mit.edu	37	chr5	37834771	37834771	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cactgctcagcgcgaagggcGcgcggcggcggccgagggag	20	13	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:37834771G>A	uc011cpi.1	-	2	328	c.128C>T	c.(127-129)GCG>GTG	p.A43V	GDNF_uc011cpc.1_Intron|GDNF_uc011cpd.1_Intron|GDNF_uc011cpe.1_Intron|GDNF_uc011cpf.1_Intron|GDNF_uc011cpg.1_Missense_Mutation_p.A60V|GDNF_uc011cph.1_Intron	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	43					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					CGCGAAGGGCGCGCGGCGGCG	0.657													0	0	0	0.115264	0	3	16										A	37834771	G	A	37834771	3	1	91	1	0	0	0	0	1	0	0	0	6322	1087	38	2	514	2	GDNF	5	37834771	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	36428447	37834771	143080489	40	27400										
GPR98	84059	broad.mit.edu	37	chr5	89990019	89990019	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aattcagacttctggacctaCaggaaaaacatgaccagggt	9	9	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:89990019C>A	uc003kju.2	+	33	7542	c.7446C>A	c.(7444-7446)TAC>TAA	p.Y2482*	GPR98_uc003kjt.2_Nonsense_Mutation_p.Y188*|GPR98_uc003kjv.2_Nonsense_Mutation_p.Y82*	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2482	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTGGACCTACAGGAAAAACA	0.493													1	0	0.000157383	0.038147	0.000160262	8	47										A	89990019	C	A	89990019	4	1	91	1	0	0	0	0	0	1	0	0	6721	489	17	4	7576	4	GPR98	5	89990019	Nonsense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	52155248	89990019	90925241	41	27401										
REEP5	7905	broad.mit.edu	37	chr5	112257852	112257852	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	atgcagttcttctcgtgcagGaaccggtcgaacctctccct	9	14	3	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:112257852G>A	uc003kqe.1	-	1	180	c.36C>T	c.(34-36)TTC>TTT	p.F12F	REEP5_uc011cvw.1_5'Flank|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Silent_p.F12F|REEP5_uc011cvz.1_RNA	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	12						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		TCTCGTGCAGGAACCGGTCGA	0.647													0	0	0	0.184627	0	5	21										A	112257852	G	A	112257852	2	1	91	1	0	0	0	0	0	0	0	1	13208	1165	41	1		1	REEP5	5	112257852	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	22267833	112257852	68657408	42	27402										
PSD2	84249	broad.mit.edu	37	chr5	139193876	139193876	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agggggtcagtgaagctgctCatcggctggcacgccgtctc	15	12	3	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:139193876C>G	uc003leu.1	+	4	1148	c.943C>G	c.(943-945)CAT>GAT	p.H315D		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	315	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAAGCTGCTCATCGGCTGGC	0.647													0	0	0	0.219247	0	22	38										G	139193876	C	G	139193876	3	3	91	1	0	0	0	0	1	0	0	0	12647	826	29	1	953	1	PSD2	5	139193876	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	26936024	139193876	41721384	43	27403										
PCDHA2	56146	broad.mit.edu	37	chr5	140176494	140176494	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cccctcgacaccgcctactcGtgctggtgaaggaccacggc	11	17	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140176494G>A	uc003lhd.2	+	1	2051	c.1945G>A	c.(1945-1947)GTG>ATG	p.V649M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.V649M|PCDHA2_uc011czy.1_Missense_Mutation_p.V649M	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	649	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCCTACTCGTGCTGGTGAA	0.652													0	0	0	0.11911	0	15	68										A	140176494	G	A	140176494	3	1	91	1	0	0	0	0	1	0	0	0	11524	1145	40	2	1947	2	PCDHA2	5	140176494	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	982618	140176494	40738766	44	27404										
PCDHB1	29930	broad.mit.edu	37	chr5	140431567	140431567	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	taacggtctccagaactacaCcctgagtgccaatgggtatt	9	11	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140431567C>A	uc003lik.1	+	1	589	c.512C>A	c.(511-513)ACC>AAC	p.T171N		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	171	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAACTACACCCTGAGTGCC	0.567													1	0	7.93312e-07	0.11911	8.33227e-07	12	75										A	140431567	C	A	140431567	3	1	91	1	0	0	0	0	1	0	0	0	11534	507	18	4	514	4	PCDHB1	5	140431567	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	255073	140431567	40483693	45	27405										
PCDHGA12	26025	broad.mit.edu	37	chr5	140811312	140811312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ggataatgcaggatattctgCgcgagccaaagtcctgatca	11	9	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:140811312C>T	uc003lkt.1	+	1	1155	c.986C>T	c.(985-987)GCG>GTG	p.A329V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.A329V	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	329	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATATTCTGCGCGAGCCAAA	0.507													0	0	0	0.139131	0	50	71										T	140811312	C	T	140811312	3	4	91	1	0	0	0	0	1	0	0	0	11553	768	27	2	988	2	PCDHGA12	5	140811312	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	379745	140811312	40103948	46	27406										
FBXO38	81545	broad.mit.edu	37	chr5	147781970	147781974	+	Frame_Shift_Del	DEL	TCATA	TCATA	-													0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggacatatatgccccatgtTcatattttggggaaatttcg							TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:147781970_147781974delTCATA	uc003lpf.1	+	5	606_610	c.486_490delTCATA	c.(484-492)GTTCATATTfs	p.V162fs	FBXO38_uc003lpg.1_Frame_Shift_Del_p.V162fs|FBXO38_uc003lph.2_Frame_Shift_Del_p.V162fs	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	162_164						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCCCATGTTCATATTTTGGGGAA	0.346																		25	67	---	---								-	147781974	TCATA	-	147781970	7	5	91	1	0	1	0	1	0	0	0	0	5746	1770	62	0	500	0	FBXO38	5	147781970	Frame_Shift_Del	DEL	TCATA	TCGA-FT-A3EE-01A-11D-A202-08	6970658	147781970	33133290	47	27407										
PWWP2A	114825	broad.mit.edu	37	chr5	159520621	159520621	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ttttttatcttcatatttagAagagtcagttgcactactac	5	7	3	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:159520621A>G	uc011ded.1	-	2	1093	c.1036T>C	c.(1036-1038)TCT>CCT	p.S346P	PWWP2A_uc003lxv.3_Missense_Mutation_p.S346P|PWWP2A_uc011dec.1_Missense_Mutation_p.S346P	NM_001130864	NP_001124336	Q96N64	PWP2A_HUMAN	PWWP domain containing 2A isoform b	346											0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATATTTAGAAGAGTCAGTT	0.328													0	0	0	0.047766	0	9	32										G	159520621	A	G	159520621	3	3	91	1	0	0	0	0	1	0	0	0	12845	246	9	5	1377	5	PWWP2A	5	159520621	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	11738651	159520621	21394639	48	27408										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171773245	171773245	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggggcgggatgggcggcttCggcaggttgaggcctcgagg	22	8	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:171773245C>T	uc003mbr.2	-	12	1254	c.1083G>A	c.(1081-1083)CCG>CCA	p.P361P		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	361					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGCGGCTTCGGCAGGTTGA	0.597													0	0	0	0.26419	0	25	105										T	171773245	C	T	171773245	2	4	91	1	0	0	0	0	0	0	0	1	14257	871	31	1		1	SH3PXD2B	5	171773245	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	12252624	171773245	9142015	49	27409										
SQSTM1	8878	broad.mit.edu	37	chr5	179263587	179263587	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tattcaaagcatcccccgccGttgtgaccacttttgcccac	6	16	1	1	rs11548636		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:179263587G>A	uc003mkw.3	+	8	1412	c.1317G>A	c.(1315-1317)CCG>CCA	p.P439P	SQSTM1_uc011dgr.1_Silent_p.P355P|SQSTM1_uc011dgs.1_Silent_p.P355P|SQSTM1_uc003mkv.3_Missense_Mutation_p.R356H|SQSTM1_uc003mkx.2_Silent_p.P355P	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	439	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATCCCCCGCCGTTGTGACCAC	0.542									Paget_Disease_of_Bone				0	0	0	0.139131	0	48	56										A	179263587	G	A	179263587	2	1	91	1	0	0	0	0	0	0	0	1	15129	1132	40	2		2	SQSTM1	5	179263587	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	7490342	179263587	1651673	50	27410										
BTNL9	153579	broad.mit.edu	37	chr5	180486555	180486555	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ctgcgagtacttcgtcctggCcccgcaccgcgtcgcgctca	11	18	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr5:180486555C>T	uc003mmt.2	+	11	1532	c.1301C>T	c.(1300-1302)GCC>GTC	p.A434V		NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	434	Cytoplasmic (Potential).|B30.2/SPRY.					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCGTCCTGGCCCCGCACCGC	0.741													0	0	0	0.146539	0	16	17										T	180486555	C	T	180486555	3	4	91	1	0	0	0	0	1	0	0	0	1568	739	26	2	1339	2	BTNL9	5	180486555	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	1222968	180486555	428705	51	27411										
RANBP9	10048	broad.mit.edu	37	chr6	13639851	13639851	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aattgtggatattcattccaTggctggggctcatacttgga	11	7	2	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:13639851T>C	uc003nbb.2	-	9	1528	c.1469A>G	c.(1468-1470)CAT>CGT	p.H490R	RANBP9_uc003nba.2_Missense_Mutation_p.H149R	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	490					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATTCATTCCATGGCTGGGGCT	0.403													0	0	0	0.173368	0	33	45										C	13639851	T	C	13639851	3	2	91	1	0	0	0	0	1	0	0	0	13032	1464	51	5	744	5	RANBP9	6	13639851	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08		13639851	157475216	52	27412										
MICB	4277	broad.mit.edu	37	chr6	31477644	31477644	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cagctgggatttcagcctctGatgtcagctactgggtccac	11	12	3	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:31477644G>C	uc003ntn.3	+	6	1226	c.1110G>C	c.(1108-1110)CTG>CTC	p.L370L	MICB_uc011dnm.1_Silent_p.L338L|MICB_uc003nto.3_Silent_p.L327L	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	370	Cytoplasmic (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						TTCAGCCTCTGATGTCAGCTA	0.577													0	0	0	0.203993	0	39	54										C	31477644	G	C	31477644	2	2	91	1	0	0	0	0	0	0	0	1	9575	1277	45	1		1	MICB	6	31477644	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	17837793	31477644	139637423	53	27413										
FTSJD2	23070	broad.mit.edu	37	chr6	37429339	37429339	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tttcagggtttctcggtggaGgggcaggagaacctgcagga	17	7	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:37429339G>A	uc003ons.2	+	11	1363	c.1110G>A	c.(1108-1110)GAG>GAA	p.E370E	FTSJD2_uc010jwu.2_Silent_p.E314E	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	370					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding	p.E370D(1)		ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TCTCGGTGGAGGGGCAGGAGA	0.512													0	0	0	0.184627	0	5	31										A	37429339	G	A	37429339	2	1	91	1	0	0	0	0	0	0	0	1	6091	991	35	2		2	FTSJD2	6	37429339	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	5951695	37429339	133685728	54	27414										
MRPS10	55173	broad.mit.edu	37	chr6	42179605	42179605	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gccttatcgtgacctttcacCaaaaccgagaggcgcttata	8	12	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr6:42179605C>G	uc003osa.3	-	4	283	c.237G>C	c.(235-237)TTG>TTC	p.L79F	MRPS10_uc011dup.1_Missense_Mutation_p.L38F	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	79					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			GACCTTTCACCAAAACCGAGA	0.363													0	0	0	0.108266	0	28	48										G	42179605	C	G	42179605	3	3	91	1	0	0	0	0	1	0	0	0	9821	593	21	4	384	4	MRPS10	6	42179605	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	4750266	42179605	128935462	55	27415										
HNRNPA2B1	3181	broad.mit.edu	37	chr7	26237281	26237281	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ccccattgttcgtagtagttCctcaaactttcttctgtggt	7	11	3	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:26237281C>T	uc003sxr.3	-	3	330	c.114G>A	c.(112-114)AGG>AGA	p.R38R	HNRNPA2B1_uc003sxs.3_Silent_p.R26R	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	38	RRM 1.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGTAGTAGTTCCTCAAACTTT	0.353			T	ETV1	prostate								0	0	0	0.160694	0	15	54										T	26237281	C	T	26237281	2	4	91	1	0	0	0	0	0	0	0	1	7259	854	30	1		1	HNRNPA2B1	7	26237281	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08		26237281	132901382	56	27416										
GLI3	2737	broad.mit.edu	37	chr7	42005031	42005031	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gctgttctccccgagggtctGatagcccccagcaggcccgc	12	17	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:42005031G>A	uc011kbh.1	-	15	3731	c.3640C>T	c.(3640-3642)CAG>TAG	p.Q1214*	GLI3_uc011kbg.1_Nonsense_Mutation_p.Q1155*	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1214					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CCGAGGGTCTGATAGCCCCCA	0.652									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.124865	0	47	69										A	42005031	G	A	42005031	4	1	91	1	0	0	0	0	0	1	0	0	6439	1299	45	1	1106	1	GLI3	7	42005031	Nonsense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	15767750	42005031	117133632	57	27417										
CCM2	83605	broad.mit.edu	37	chr7	45108111	45108111	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cagaggcctcagtgcaggctCcctgtcggagagtgcagttg	15	11	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:45108111C>A	uc003tmo.2	+	5	688	c.542C>A	c.(541-543)TCC>TAC	p.S181Y	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Missense_Mutation_p.S123Y|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Intron|CCM2_uc011kcb.1_Missense_Mutation_p.S144Y|CCM2_uc011kcc.1_Intron|CCM2_uc003tms.2_Missense_Mutation_p.S202Y	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	181	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						AGTGCAGGCTCCCTGTCGGAG	0.592									Familial_Cerebral_Cavernous_Angioma				1	0	6.1207e-33	0.131918	7.00107e-33	46	62										A	45108111	C	A	45108111	3	1	91	1	0	0	0	0	1	0	0	0	2908	855	30	3	657	3	CCM2	7	45108111	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	3103080	45108111	114030552	58	27418										
POM121L12	285877	broad.mit.edu	37	chr7	53103824	53103824	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aggagagcccctggagatccCctggacagagagcccgcccc	13	16	0	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:53103824C>T	uc003tpz.2	+	1	476	c.460C>T	c.(460-462)CCT>TCT	p.P154S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	154											0						CTGGAGATCCCCTGGACAGAG	0.592													0	0	0	0.09319	0	13	27										T	53103824	C	T	53103824	3	4	91	1	0	0	0	0	1	0	0	0	12241	623	22	2	462	2	POM121L12	7	53103824	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	7995713	53103824	106034839	59	27419										
MAGI2	9863	broad.mit.edu	37	chr7	78130897	78130897	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aaatgtgtgaaactcactcaAtgaagtagacttcgcccttc	7	10	2	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:78130897A>G	uc003ugx.2	-	5	1216	c.962T>C	c.(961-963)ATT>ACT	p.I321T	MAGI2_uc003ugy.2_Missense_Mutation_p.I321T|MAGI2_uc011kgr.1_Missense_Mutation_p.I153T|MAGI2_uc011kgs.1_Missense_Mutation_p.I158T	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	321	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AACTCACTCAATGAAGTAGAC	0.388													0	0	0	0.146539	0	17	67										G	78130897	A	G	78130897	3	3	91	1	0	0	0	0	1	0	0	0	9191	101	4	5	3477	5	MAGI2	7	78130897	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	25027073	78130897	81007766	60	27420										
PCLO	27445	broad.mit.edu	37	chr7	82580339	82580339	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	caccacttcaggaaacacttCggatgctgtggttaaagtgg	11	9	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:82580339C>T	uc003uhx.2	-	6	9854	c.9565G>A	c.(9565-9567)GAA>AAA	p.E3189K	PCLO_uc003uhv.2_Missense_Mutation_p.E3189K|PCLO_uc010lec.2_Missense_Mutation_p.E154K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3120					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAAACACTTCGGATGCTGTG	0.443													0	0	0	0.080935	0	12	18										T	82580339	C	T	82580339	3	4	91	1	0	0	0	0	1	0	0	0	11583	893	31	1	5960	1	PCLO	7	82580339	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	4449442	82580339	76558324	61	27421										
ADAM22	53616	broad.mit.edu	37	chr7	87762258	87762258	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgttgctgaaaggaggaggcGtgaatgaagtaggtgtgaac	17	4	0	4			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:87762258G>A	uc003ujn.2	+	12	1148	c.1069G>A	c.(1069-1071)GTG>ATG	p.V357M	ADAM22_uc003ujk.1_Missense_Mutation_p.V357M|ADAM22_uc003ujl.1_Missense_Mutation_p.V357M|ADAM22_uc003ujm.2_Missense_Mutation_p.V357M|ADAM22_uc003ujo.2_Missense_Mutation_p.V357M|ADAM22_uc003ujp.1_Missense_Mutation_p.V409M	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	357	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGGAGGCGTGAATGAAGT	0.398													0	0	0	0.248553	0	5	70										A	87762258	G	A	87762258	3	1	91	1	0	0	0	0	1	0	0	0	244	1145	40	2	1115	2	ADAM22	7	87762258	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	5181919	87762258	71376405	62	27422										
ACTL6B	51412	broad.mit.edu	37	chr7	100244899	100244899	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	acggaggcctggaagtcctgGatcacctcctgaaatcccag	11	13	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:100244899G>A	uc003uvy.2	-	9	875	c.768C>T	c.(766-768)ATC>ATT	p.I256I	ACTL6B_uc003uvx.1_Silent_p.I47I|ACTL6B_uc003uvz.2_RNA	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	256					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGAAGTCCTGGATCACCTCCT	0.672													0	0	0	0.249174	0	22	23										A	100244899	G	A	100244899	2	1	91	1	0	0	0	0	0	0	0	1	199	1164	41	1		1	ACTL6B	7	100244899	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	12482641	100244899	58893764	63	27423										
GPR37	2861	broad.mit.edu	37	chr7	124386891	124386891	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	taggcagtaacaatgttgcaGatattttcaggaataatgca	9	5	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:124386891G>C	uc003vli.2	-	2	2181	c.1530C>G	c.(1528-1530)ATC>ATG	p.I510M		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	510	Helical; Name=6; (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CAATGTTGCAGATATTTTCAG	0.418													0	0	0	0.234183	0	22	72										C	124386891	G	C	124386891	3	2	91	1	0	0	0	0	1	0	0	0	6691	932	33	1	315	1	GPR37	7	124386891	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	24141992	124386891	34751772	64	27424										
ZNF862	643641	broad.mit.edu	37	chr7	149558351	149558351	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ggggacggatggctcagccaTgttgagctgcagaggaggcc	18	9	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:149558351T>C	uc010lpn.2	+	7	2294	c.2102T>C	c.(2101-2103)ATG>ACG	p.M701T	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	701					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						GGCTCAGCCATGTTGAGCTGC	0.632													0	0	0	0.115264	0	3	11										C	149558351	T	C	149558351	3	2	91	1	0	0	0	0	1	0	0	0	18192	1464	51	5	2128	5	ZNF862	7	149558351	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	25171460	149558351	9580312	65	27425										
NUB1	51667	broad.mit.edu	37	chr7	151042482	151042482	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aaaattgacccagtttttaaGggaagacaggattcaacttt	8	6	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr7:151042482G>T	uc003wjx.2	+	2	124	c.119G>T	c.(118-120)AGG>ATG	p.R40M	NUB1_uc011kvi.1_Missense_Mutation_p.R40M|NUB1_uc003wjv.2_RNA|NUB1_uc003wjw.2_Missense_Mutation_p.R16M|NUB1_uc010lqb.2_RNA|NUB1_uc003wjy.2_RNA	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	16					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CAGTTTTTAAGGGAAGACAGG	0.303													1	0	2.17888e-05	0.058154	2.24613e-05	9	21										T	151042482	G	T	151042482	3	4	91	1	0	0	0	0	1	0	0	0	10714	1000	35	4	49	4	NUB1	7	151042482	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	1484131	151042482	8096181	66	27426										
SGK223	157285	broad.mit.edu	37	chr8	8235550	8235550	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	acgggggcatcctcctgcttCgggagggggagcttgccagg	18	11	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:8235550C>T	uc003wsh.3	-	2	369	c.369G>A	c.(367-369)CCG>CCA	p.P123P		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	123							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CCTCCTGCTTCGGGAGGGGGA	0.552													0	0	0	0.203993	0	36	19										T	8235550	C	T	8235550	2	4	91	1	0	0	0	0	0	0	0	1	14210	871	31	1		1	SGK223	8	8235550	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08		8235550	138128472	67	27427										
TEX15	56154	broad.mit.edu	37	chr8	30702216	30702216	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agaggagccttttacattatCttttaaaagcagagaactat	7	6	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:30702216C>A	uc003xil.2	-	1	4318	c.4318G>T	c.(4318-4320)GAT>TAT	p.D1440Y		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1440										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTTACATTATCTTTTAAAAGC	0.348													1	0	0.000157383	0.038147	0.000160262	8	28										A	30702216	C	A	30702216	3	1	91	1	0	0	0	0	1	0	0	0	15776	913	32	3	4067	3	TEX15	8	30702216	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	22466666	30702216	115661806	68	27428										
PRKDC	5591	broad.mit.edu	37	chr8	48690396	48690396	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	catcagattgataaactggcGagttagccgaaaaggcatca	10	8	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr8:48690396G>A	uc003xqi.2	-	85	11950	c.11893C>T	c.(11893-11895)CGC>TGC	p.R3965C	PRKDC_uc003xqj.2_Missense_Mutation_p.R3934C|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3965	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATAAACTGGCGAGTTAGCCGA	0.483								NHEJ					0	0	0	0.105934	0	14	73										A	48690396	G	A	48690396	3	1	91	1	0	0	0	0	1	0	0	0	12521	1058	37	1	505	1	PRKDC	8	48690396	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	17988180	48690396	97673626	69	27429										
SHB	6461	broad.mit.edu	37	chr9	37955959	37955959	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agggctcccatgtttgatagGcttaaagccccctccagggg	12	12	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:37955959G>C	uc004aax.2	-	4	1715	c.1147C>G	c.(1147-1149)CCT>GCT	p.P383A		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	383	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TGTTTGATAGGCTTAAAGCCC	0.597													0	0	0	0.184627	0	5	2										C	37955959	G	C	37955959	3	2	91	1	0	0	0	0	1	0	0	0	14268	1203	42	4	394	4	SHB	9	37955959	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		37955959	103257472	70	27430										
KIAA0368	23392	broad.mit.edu	37	chr9	114151916	114151916	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gttgggatcaaactggtaacGataaagtcgaggaactagct	12	6	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:114151916G>T	uc004bfe.1	-	32	3901	c.3901C>A	c.(3901-3903)CGT>AGT	p.R1301S		NM_001080398	NP_001073867			KIAA0368 protein												0						AACTGGTAACGATAAAGTCGA	0.453													1	0	2.23348e-06	0.146539	2.31672e-06	17	23										T	114151916	G	T	114151916	3	4	91	1	0	0	0	0	1	0	0	0	8171	1058	37	3	2232	3	KIAA0368	9	114151916	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	76195957	114151916	27061515	71	27431										
SLC46A2	57864	broad.mit.edu	37	chr9	115652599	115652599	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agcaccttgagcagcagcccGaggcgggagagcaggaagcc	16	12	0	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr9:115652599G>A	uc004bgk.2	-	1	595	c.363C>T	c.(361-363)CTC>CTT	p.L121L		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	121	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						GCAGCAGCCCGAGGCGGGAGA	0.677													0	0	0	0.099896	0	28	12										A	115652599	G	A	115652599	2	1	91	1	0	0	0	0	0	0	0	1	14645	1045	37	1		1	SLC46A2	9	115652599	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	1500683	115652599	25560832	72	27432										
ARMC3	219681	broad.mit.edu	37	chr10	23326230	23326230	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tagaattggcattggttgctCcctagttcgcggagagtacg	13	8	0	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:23326230C>G	uc001irm.3	+	19	2524	c.2441C>G	c.(2440-2442)TCC>TGC	p.S814C	ARMC3_uc010qcv.1_Missense_Mutation_p.S807C|ARMC3_uc010qcw.1_Missense_Mutation_p.S551C	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	814							binding				0						ATTGGTTGCTCCCTAGTTCGC	0.532													0	0	0	0.116897	0	26	59										G	23326230	C	G	23326230	3	3	91	1	0	0	0	0	1	0	0	0	952	855	30	1	2511	1	ARMC3	10	23326230	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08		23326230	112208517	73	27433										
BAMBI	25805	broad.mit.edu	37	chr10	28970934	28970934	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	caaggaaacaggtatcagcaTgatggtagcagaaaccttat	10	7	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:28970934T>A	uc001iuj.1	+	3	790	c.387T>A	c.(385-387)CAT>CAA	p.H129Q	BAMBI_uc001iui.2_3'UTR	NM_012342	NP_036474	Q13145	BAMBI_HUMAN	BMP and activin membrane-bound inhibitor	129	Extracellular (Potential).				cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|positive regulation of protein binding|positive regulation of transcription, DNA-dependent|regulation of cell shape	cytoplasm|integral to membrane|plasma membrane	frizzled binding|type II transforming growth factor beta receptor binding			central_nervous_system(4)	4						GGTATCAGCATGATGGTAGCA	0.453													0	0	0	0.214465	0	38	67										A	28970934	T	A	28970934	3	1	91	1	0	0	0	0	1	0	0	0	1306	1461	51	5	397	5	BAMBI	10	28970934	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	5644704	28970934	106563813	74	27434										
ZNF37A	7587	broad.mit.edu	37	chr10	38407014	38407014	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gaagaccttctataagaattCagacctcattaaacatcaaa	4	9	4	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:38407014C>G	uc001izk.2	+	8	1754	c.935C>G	c.(934-936)TCA>TGA	p.S312*	ZNF37A_uc001izl.2_Nonsense_Mutation_p.S312*|ZNF37A_uc001izm.2_Nonsense_Mutation_p.S312*	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	312	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						TATAAGAATTCAGACCTCATT	0.423													0	0	0	0.193644	0	36	76										G	38407014	C	G	38407014	4	3	91	1	0	0	0	0	0	1	0	0	17869	838	29	1	949	1	ZNF37A	10	38407014	Nonsense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	9436080	38407014	97127733	75	27435										
MYOZ1	58529	broad.mit.edu	37	chr10	75391746	75391746	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tatccacgttgtagtctacaGgctccccagagctcagccag	9	14	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:75391746G>A	uc001jur.2	-	6	1207	c.842C>T	c.(841-843)CCT>CTT	p.P281L		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	281					myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					GTAGTCTACAGGCTCCCCAGA	0.532													0	0	0	0.204396	0	21	32										A	75391746	G	A	75391746	3	1	91	1	0	0	0	0	1	0	0	0	10095	1000	35	2	61	2	MYOZ1	10	75391746	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	36984732	75391746	60143001	76	27436										
RNLS	55328	broad.mit.edu	37	chr10	90034726	90034726	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	atttccaggaagtcagatggGaaatccaatcgccatcatcc	8	11	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:90034726G>A	uc001kfd.2	-	7	1075	c.940C>T	c.(940-942)CCC>TCC	p.P314S	RNLS_uc010qms.1_Missense_Mutation_p.P231S	NM_018363	NP_060833	Q5VYX0	RNLS_HUMAN	renalase isoform 2	Error:Variant_position_missing_in_Q5VYX0_after_alignment						extracellular region	oxidoreductase activity			ovary(1)	1						AGTCAGATGGGAAATCCAATC	0.348													0	0	0	0.069234	0	10	40										A	90034726	G	A	90034726	3	1	91	1	0	0	0	0	1	0	0	0	13505	1174	41	1	11	1	RNLS	10	90034726	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	14642980	90034726	45500021	77	27437										
SORBS1	10580	broad.mit.edu	37	chr10	97141472	97141472	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ttggtcagaacggaagacttGccaggctgatattcgtaaat	11	7	1	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:97141472G>T	uc001kkp.2	-	16	1668	c.1623C>A	c.(1621-1623)GGC>GGA	p.G541G	SORBS1_uc001kkk.2_Silent_p.G119G|SORBS1_uc001kkl.2_Silent_p.G143G|SORBS1_uc001kkn.2_Silent_p.G328G|SORBS1_uc001kkm.2_Silent_p.G397G|SORBS1_uc001kko.2_Silent_p.G563G|SORBS1_uc001kkq.2_Silent_p.G426G|SORBS1_uc001kkr.2_Silent_p.G331G|SORBS1_uc001kks.2_Silent_p.G331G|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Silent_p.G372G|SORBS1_uc001kkv.2_Silent_p.G463G|SORBS1_uc001kkw.2_Silent_p.G495G|SORBS1_uc010qoe.1_Silent_p.G340G|SORBS1_uc010qof.1_Silent_p.G693G	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	541					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CGGAAGACTTGCCAGGCTGAT	0.403													1	0	2.32078e-09	0.132662	2.50046e-09	14	79										T	97141472	G	T	97141472	2	4	91	1	0	0	0	0	0	0	0	1	14927	1306	46	4		4	SORBS1	10	97141472	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	7106746	97141472	38393275	78	27438										
PPRC1	23082	broad.mit.edu	37	chr10	103907098	103907098	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	atcctcatcatcgtcttcctCatcccgatctcggtccaggt	6	16	5	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr10:103907098C>T	uc001kum.2	+	9	4388	c.4349C>T	c.(4348-4350)TCA>TTA	p.S1450L	PPRC1_uc001kun.2_Missense_Mutation_p.S1330L|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1450	Arg-rich.|Necessary for interaction with CREB1 and NRF1.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TCGTCTTCCTCATCCCGATCT	0.597													0	0	0	0.193644	0	34	22										T	103907098	C	T	103907098	3	4	91	1	0	0	0	0	1	0	0	0	12410	838	29	1	4383	1	PPRC1	10	103907098	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	6765626	103907098	31627649	79	27439										
HRAS	3265	broad.mit.edu	37	chr11	533875	533875	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	catggcgctgtactcctcctGgccggcggtatccaggatgt	13	13	0	0	rs28933406		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:533875G>T	uc001lpv.2	-	3	369	c.181C>A	c.(181-183)CAG>AAG	p.Q61K	HRAS_uc010qvw.1_Missense_Mutation_p.Q61K|HRAS_uc010qvx.1_Missense_Mutation_p.Q61K|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	61	GTP.		Q -> L (in melanoma; strongly reduced GTP hydrolysis in the presence of RAF1; increases transformation of cultured cell lines).	Q->V: Strongly increased transformation of cultured cell lines.|Q->I: Moderately increased transformation of cultured cell lines.	activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.Q61R(112)|p.Q61L(91)|p.Q61K(39)|p.Q61H(20)|p.Q61P(3)|p.Q61Q(1)|p.Q61E(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TACTCCTCCTGGCCGGCGGTA	0.597		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			1	0	5.20837e-25	0.268233	5.91699e-25	41	42										T	533875	G	T	533875	3	4	91	1	0	0	0	0	1	0	0	0	7348	1357	47	4	467	4	HRAS	11	533875	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		533875	134472641	80	27440										
BRSK2	9024	broad.mit.edu	37	chr11	1463777	1463777	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gagaagaacaacatccgcatCgcagactttggcatggcgtc	11	11	0	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:1463777C>T	uc001lti.2	+	5	857	c.471C>T	c.(469-471)ATC>ATT	p.I157I	BRSK2_uc009ycv.1_Silent_p.I157I|BRSK2_uc001lth.1_Silent_p.I157I|BRSK2_uc001ltj.2_Silent_p.I157I|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Silent_p.I157I|BRSK2_uc001ltm.2_Silent_p.I203I|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	157	Protein kinase.				establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		ACATCCGCATCGCAGACTTTG	0.622													0	0	0	0.204396	0	19	9										T	1463777	C	T	1463777	2	4	91	1	0	0	0	0	0	0	0	1	1524	874	31	1		1	BRSK2	11	1463777	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	929902	1463777	133542739	81	27441										
OR56B4	196335	broad.mit.edu	37	chr11	6129922	6129922	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	caggatgcacaaactcagacTgggctttcagagactgcttg	11	10	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:6129922T>A	uc010qzx.1	+	1	914	c.914T>A	c.(913-915)CTG>CAG	p.L305Q		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAACTCAGACTGGGCTTTCAG	0.488													0	0	0	0.139131	0	57	51										A	6129922	T	A	6129922	3	1	91	1	0	0	0	0	1	0	0	0	11138	1580	55	5	916	5	OR56B4	11	6129922	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	4666145	6129922	128876594	82	27442										
PC	5091	broad.mit.edu	37	chr11	66636412	66636412	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ctgtccaccaggaactccacGgtgcctgcgttctcgtagcc	10	16	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:66636412G>C	uc001ojn.1	-	8	976	c.927C>G	c.(925-927)ACC>ACG	p.T309T	PC_uc001ojo.1_Silent_p.T309T|PC_uc001ojp.1_Silent_p.T309T	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	309	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GGAACTCCACGGTGCCTGCGT	0.637													0	0	0	0.219247	0	17	49										C	66636412	G	C	66636412	2	2	91	1	0	0	0	0	0	0	0	1	11497	1103	39	4		4	PC	11	66636412	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	60506490	66636412	68370104	83	27443										
KBTBD3	143879	broad.mit.edu	37	chr11	105923955	105923955	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ccaaactctgctactagttcAgaccactgatcagttgtagc	7	12	3	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:105923955A>G	uc001pja.2	-	4	2101	c.1461T>C	c.(1459-1461)TCT>TCC	p.S487S	KBTBD3_uc001pjb.2_Silent_p.S487S|KBTBD3_uc009yxm.2_Silent_p.S408S	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	483	Kelch 4.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		CTACTAGTTCAGACCACTGAT	0.348													0	0	0	0.204396	0	21	8										G	105923955	A	G	105923955	2	3	91	1	0	0	0	0	0	0	0	1	7994	175	7	5		5	KBTBD3	11	105923955	Silent	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	39287543	105923955	29082561	84	27444										
ATM	472	broad.mit.edu	37	chr11	108115703	108115703	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agtcattattgaattatttcAactgcaaatttatatccatc	3	7	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:108115703A>C	uc001pkb.1	+	7	1236	c.851A>C	c.(850-852)CAA>CCA	p.Q284P	ATM_uc009yxr.1_Missense_Mutation_p.Q284P	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	284					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAATTATTTCAACTGCAAATT	0.308			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.234183	0	22	20										C	108115703	A	C	108115703	3	2	91	1	0	0	0	0	1	0	0	0	1109	130	5	5	873	5	ATM	11	108115703	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	2191748	108115703	26890813	85	27445										
SIDT2	51092	broad.mit.edu	37	chr11	117064644	117064645	+	In_Frame_Ins	INS	-	-	TCT													0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgtggtctggggcttcgcgcINStcttcttcttcttccaggga							TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr11:117064644_117064645insTCT	uc001pqh.1	+	24	2328_2329	c.2287_2288insTCT	c.(2287-2289)CTC>CTCTTC	p.767_768insF	SIDT2_uc010rxe.1_In_Frame_Ins_p.767_768insF|SIDT2_uc001pqg.2_In_Frame_Ins_p.788_789insF|SIDT2_uc001pqi.1_In_Frame_Ins_p.764_765insF|SIDT2_uc001pqj.1_In_Frame_Ins_p.79_80insF	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	767_768	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		GGGCTTCGCGCTCTTCTTCTTC	0.604																		20	26	---	---								TCT	117064645	-	TCT	117064644	7	5	91	1	0	1	1	0	0	0	0	0	14303	797	28	0	2381	0	SIDT2	11	117064644	In_Frame_Ins	INS	-	TCGA-FT-A3EE-01A-11D-A202-08	8948941	117064644	17941872	86	27446										
LRTM2	654429	broad.mit.edu	37	chr12	1940432	1940432	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agcatcaggaccctggacagGgacctgctgcggcactcgcc	13	15	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:1940432G>A	uc001qjt.2	+	4	1205	c.399G>A	c.(397-399)AGG>AGA	p.R133R	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Silent_p.R133R|LRTM2_uc010sdx.1_Silent_p.R133R|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	133	Extracellular (Potential).|LRR 3.					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCCTGGACAGGGACCTGCTGC	0.637											OREG0005740	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=CACNA2D4|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	0	0	0	0.09319	0	12	61										A	1940432	G	A	1940432	2	1	91	1	0	0	0	0	0	0	0	1	9045	1223	43	2		2	LRTM2	12	1940432	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		1940432	131911463	87	27447										
KCNA1	3736	broad.mit.edu	37	chr12	5020962	5020962	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	acgagggcttcatcaaggagGaggagcgccctctgcccgag	15	12	3	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:5020962G>T	uc001qnh.2	+	2	1523	c.418G>T	c.(418-420)GAG>TAG	p.E140*		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	140					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATCAAGGAGGAGGAGCGCCC	0.627													1	0	7.05477e-17	0.160694	7.90702e-17	18	45										T	5020962	G	T	5020962	4	4	91	1	0	0	0	0	0	1	0	0	8001	1175	41	3	420	3	KCNA1	12	5020962	Nonsense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	3080530	5020962	128830933	88	27448										
PIK3C2G	5288	broad.mit.edu	37	chr12	18644430	18644430	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gactagaagagttctttcaaGatgtaaatacttgtcatctt	7	6	4	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:18644430G>A	uc001rdt.2	+	19	2724	c.2608G>A	c.(2608-2610)GAT>AAT	p.D870N	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.D911N|PIK3C2G_uc010sic.1_Missense_Mutation_p.D689N	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	870					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTTCTTTCAAGATGTAAATAC	0.333													0	0	0	0.11911	0	12	59										A	18644430	G	A	18644430	3	1	91	1	0	0	0	0	1	0	0	0	11911	942	33	1	2678	1	PIK3C2G	12	18644430	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	13623468	18644430	115207465	89	27449										
COL2A1	1280	broad.mit.edu	37	chr12	48375154	48375154	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cacgagcaccagcacttcctGcaggaccaggaggtccaact	10	15	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:48375154G>A	uc001rqu.2	-	37	2616	c.2435C>T	c.(2434-2436)GCA>GTA	p.A812V	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.A743V	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	812	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGCACTTCCTGCAGGACCAGG	0.637													0	0	0	0.184627	0	4	9										A	48375154	G	A	48375154	3	1	91	1	0	0	0	0	1	0	0	0	3687	1319	46	2	2100	2	COL2A1	12	48375154	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	29730724	48375154	85476741	90	27450										
RARG	5916	broad.mit.edu	37	chr12	53607337	53607337	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ctcggtgtcatccatctccaGgggcaggagctgcccagcaa	12	14	2	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:53607337G>C	uc001sce.2	-	8	1446	c.961C>G	c.(961-963)CTG>GTG	p.L321V	RARG_uc001scd.2_Missense_Mutation_p.L310V|RARG_uc010sob.1_Missense_Mutation_p.L299V|RARG_uc001scf.2_Missense_Mutation_p.L321V|RARG_uc001scg.2_Missense_Mutation_p.L249V|RARG_uc010soc.1_Missense_Mutation_p.L200V|RARG_uc010sod.1_Missense_Mutation_p.L358V	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	321	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	TCCATCTCCAGGGGCAGGAGC	0.652											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.09319	0	13	29										C	53607337	G	C	53607337	3	2	91	1	0	0	0	0	1	0	0	0	13054	991	35	4	415	4	RARG	12	53607337	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	5232183	53607337	80244558	91	27451										
LTA4H	4048	broad.mit.edu	37	chr12	96394858	96394858	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aggttcggacagcttgatcaTgggatttgtcaaaggcagca	13	7	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:96394858T>C	uc001ten.1	-	19	1813	c.1745A>G	c.(1744-1746)CAT>CGT	p.H582R	LTA4H_uc010suy.1_Missense_Mutation_p.H544R|LTA4H_uc010suz.1_3'UTR	NM_000895	NP_000886	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	582					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)	1						AGCTTGATCATGGGATTTGTC	0.363													0	0	0	0.058154	0	9	50										C	96394858	T	C	96394858	3	2	91	1	0	0	0	0	1	0	0	0	9069	1464	51	5	94	5	LTA4H	12	96394858	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	42787521	96394858	37457037	92	27452										
B3GNT4	79369	broad.mit.edu	37	chr12	122689184	122689184	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tcatgcttcctccccagcctTccgcagcccaccagggaagg	9	18	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:122689184T>G	uc001ubx.2	+	2	237	c.19T>G	c.(19-21)TCC>GCC	p.S7A	B3GNT4_uc001uby.2_Intron	NM_030765	NP_110392	Q9C0J1	B3GN4_HUMAN	UDP-GlcNAc:betaGal	7	Cytoplasmic (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000297)|Epithelial(86;0.000497)|BRCA - Breast invasive adenocarcinoma(302;0.222)		TCCCCAGCCTTCCGCAGCCCA	0.537													0	0	0	0.038147	0	7	26										G	122689184	T	G	122689184	3	3	91	1	0	0	0	0	1	0	0	0	1259	1783	62	5	21	5	B3GNT4	12	122689184	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	26294326	122689184	11162711	93	27453										
GPR133	283383	broad.mit.edu	37	chr12	131476886	131476886	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tacctccaaaatgtatccctCagcttacccagtaagtccct	4	15	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr12:131476886C>T	uc001uit.3	+	8	1474	c.915C>T	c.(913-915)CTC>CTT	p.L305L	GPR133_uc010tbm.1_Silent_p.L337L	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	305	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ATGTATCCCTCAGCTTACCCA	0.502													0	0	0	0.116897	0	30	86										T	131476886	C	T	131476886	2	4	91	1	0	0	0	0	0	0	0	1	6643	813	29	1		1	GPR133	12	131476886	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	8787702	131476886	2375009	94	27454										
MIPEP	4285	broad.mit.edu	37	chr13	24304530	24304530	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tttcgaagtccagatccaagTcggaaacgagggcacttacg	11	10	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:24304530T>C	uc001uox.3	-	19	2199	c.2099A>G	c.(2098-2100)GAC>GGC	p.D700G		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	700					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CAGATCCAAGTCGGAAACGAG	0.413													0	0	0	0.219247	0	21	11										C	24304530	T	C	24304530	3	2	91	1	0	0	0	0	1	0	0	0	9592	1667	58	5	46	5	MIPEP	13	24304530	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08		24304530	90865348	95	27455										
BRCA2	675	broad.mit.edu	37	chr13	32900694	32900694	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agctgaggtggatcctgataTgtcttggtcaagttctttag	12	6	3	2	rs80358805		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:32900694T>C	uc001uub.1	+	7	802	c.575T>C	c.(574-576)ATG>ACG	p.M192T	BRCA2_uc001uua.1_Missense_Mutation_p.M69T	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	192			M -> T (in one patient with pancreatic cancer).		cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GATCCTGATATGTCTTGGTCA	0.393			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.139131	0	45	37										C	32900694	T	C	32900694	3	2	91	1	0	0	0	0	1	0	0	0	1499	1464	51	5	597	5	BRCA2	13	32900694	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	8596164	32900694	82269184	96	27456										
LPAR6	10161	broad.mit.edu	37	chr13	48985612	48985612	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tctgcaccatgaacttcagaGaatctgaagtcacttctcct	6	12	5	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:48985612G>A	uc010acu.2	-	1	2042	c.948C>T	c.(946-948)TTC>TTT	p.F316F	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Silent_p.F316F|LPAR6_uc001vcf.2_Silent_p.F316F	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GAACTTCAGAGAATCTGAAGT	0.338													0	0	0	0.26419	0	24	87										A	48985612	G	A	48985612	2	1	91	1	0	0	0	0	0	0	0	1	8909	933	33	1		1	LPAR6	13	48985612	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	16084918	48985612	66184266	97	27457										
MLNR	2862	broad.mit.edu	37	chr13	49795318	49795318	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gagcagccggcggccgctgcGaggcccggccgcctcggggc	19	17	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:49795318G>A	uc010tgj.1	+	1	845	c.845G>A	c.(844-846)CGA>CAA	p.R282Q		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	282	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CGGCCGCTGCGAGGCCCGGCC	0.701													0	0	0	0.204396	0	20	4										A	49795318	G	A	49795318	3	1	91	1	0	0	0	0	1	0	0	0	9632	1058	37	1	847	1	MLNR	13	49795318	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	809706	49795318	65374560	98	27458										
MYCBP2	23077	broad.mit.edu	37	chr13	77750673	77750673	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aagtctgatctcagctatatCactgggtgagtcatccgttg	10	9	4	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:77750673C>T	uc001vkf.2	-	37	5408	c.5317G>A	c.(5317-5319)GAT>AAT	p.D1773N	MYCBP2_uc010aev.2_Missense_Mutation_p.D1177N	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TCAGCTATATCACTGGGTGAG	0.363													0	0	0	0.248553	0	6	24										T	77750673	C	T	77750673	3	4	91	1	0	0	0	0	1	0	0	0	10018	826	29	1	8797	1	MYCBP2	13	77750673	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	27955355	77750673	37419205	99	27459										
FAM70B	348013	broad.mit.edu	37	chr13	114514838	114514838	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgtgctacgcacccacctacTttcccccgggggagaagcca	10	17	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr13:114514838T>C	uc001vuh.2	+	9	970	c.943T>C	c.(943-945)TTT>CTT	p.F315L		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	315	Pro-rich.					integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			ACCCACCTACTTTCCCCCGGG	0.567													0	0	0	0.204396	0	18	75										C	114514838	T	C	114514838	3	2	91	1	0	0	0	0	1	0	0	0	5606	1609	56	5	977	5	FAM70B	13	114514838	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	36764165	114514838	655040	100	27460										
TC2N	123036	broad.mit.edu	37	chr14	92278710	92278710	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tgtcctgggttgaatgtaagAtaacttaaacttgggcacca	10	7	0	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:92278710A>G	uc001xzu.3	-	3	438	c.247T>C	c.(247-249)TCT>CCT	p.S83P	TC2N_uc001xzt.3_Missense_Mutation_p.S83P|TC2N_uc010auc.2_Missense_Mutation_p.S83P|TC2N_uc001xzv.3_Missense_Mutation_p.S83P	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	83						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		TGAATGTAAGATAACTTAAAC	0.363													0	0	0	0.11911	0	14	19										G	92278710	A	G	92278710	3	3	91	1	0	0	0	0	1	0	0	0	15662	333	12	5	1265	5	TC2N	14	92278710	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08		92278710	15070830	101	27461										
CDC42BPB	9578	broad.mit.edu	37	chr14	103440459	103440459	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ggcgaagcgccactgtgtccTcaagctgtcgctcgagcctg	13	14	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:103440459T>G	uc001ymi.1	-	12	1767	c.1535A>C	c.(1534-1536)GAG>GCG	p.E512A		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	512	Potential.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CACTGTGTCCTCAAGCTGTCG	0.532													0	0	0	0.09319	0	12	36										G	103440459	T	G	103440459	3	3	91	1	0	0	0	0	1	0	0	0	3073	1551	54	5	3704	5	CDC42BPB	14	103440459	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	11161749	103440459	3909081	102	27462										
TDRD9	122402	broad.mit.edu	37	chr14	104471727	104471727	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agtgacattgagcgcaccatCcttctactaaaggaggtagg	11	9	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr14:104471727C>T	uc001yom.3	+	15	1728	c.1698C>T	c.(1696-1698)ATC>ATT	p.I566I	TDRD9_uc001yon.3_Silent_p.I304I	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	566					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				AGCGCACCATCCTTCTACTAA	0.532													0	0	0	0.105934	0	14	26										T	104471727	C	T	104471727	2	4	91	1	0	0	0	0	0	0	0	1	15733	845	30	1		1	TDRD9	14	104471727	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	1031268	104471727	2877813	103	27463										
MESDC2	23184	broad.mit.edu	37	chr15	81282111	81282111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aagcaggaccacggccttgcGcgcccacctggaagccgcca	12	17	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr15:81282111G>A	uc002bfy.1	-	1	95	c.22C>T	c.(22-24)CGC>TGC	p.R8C	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	8	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						ACGGCCTTGCGCGCCCACCTG	0.647													0	0	0	0.09319	0	13	3										A	81282111	G	A	81282111	3	1	91	1	0	0	0	0	1	0	0	0	9481	1087	38	2	694	2	MESDC2	15	81282111	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		81282111	21249281	104	27464										
KIAA0430	9665	broad.mit.edu	37	chr16	15705592	15705592	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ttggagcccattccaagaatCtgcaaagcaaatagtttatt	7	8	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:15705592C>T	uc002ddr.2	-	18	3668	c.3475_splice	c.e18-1	p.I1159_splice	KIAA0430_uc002ddq.2_Splice_Site_p.I993_splice|KIAA0430_uc010uzv.1_Splice_Site_p.I1155_splice|KIAA0430_uc010uzw.1_Splice_Site_p.I1158_splice	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1							peroxisome	nucleotide binding|RNA binding				0						TTCCAAGAATCTGCAAAGCAA	0.488													0	0	0	0.26419	0	24	26										T	15705592	C	T	15705592	5	4	91	1	0	0	0	0	0	0	1	0	8177	927	32	1	1794	1	KIAA0430	16	15705592	Splice_Site	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08		15705592	74649161	105	27465										
SCNN1G	6340	broad.mit.edu	37	chr16	23224042	23224042	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cgagcctttgtccaggaagaGctgggctgccagtctgtgtg	15	10	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:23224042G>T	uc002dlm.1	+	9	1477	c.1338G>T	c.(1336-1338)GAG>GAT	p.E446D		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	446	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TCCAGGAAGAGCTGGGCTGCC	0.587													1	0	4.96729e-08	0.204396	5.25024e-08	18	71										T	23224042	G	T	23224042	3	4	91	1	0	0	0	0	1	0	0	0	13930	962	34	4	1368	4	SCNN1G	16	23224042	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	7518450	23224042	67130711	106	27466										
ERN2	10595	broad.mit.edu	37	chr16	23718361	23718361	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cccatcagagctgcggcaggGagaggcatgaaccagctcag	14	12	2	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:23718361G>T	uc002dma.3	-	5	659	c.490C>A	c.(490-492)CCC>ACC	p.P164T	ERN2_uc010bxp.2_Missense_Mutation_p.P164T|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	116	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CTGCGGCAGGGAGAGGCATGA	0.552													1	0	1.05317e-09	0.11911	1.14207e-09	13	27										T	23718361	G	T	23718361	3	4	91	1	0	0	0	0	1	0	0	0	5238	1174	41	3	2506	3	ERN2	16	23718361	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	494319	23718361	66636392	107	27467										
TMEM208	29100	broad.mit.edu	37	chr16	67262275	67262275	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	caggccatttactgccttgtGacgttggtcttcttttactc	8	11	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:67262275G>A	uc002esi.2	+	3	226	c.120G>A	c.(118-120)GTG>GTA	p.V40V	LRRC29_uc002ese.2_5'Flank|LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|TMEM208_uc002esj.2_RNA	NM_014187	NP_054906	Q9BTX3	TM208_HUMAN	HSPC171 protein	40	Helical; (Potential).					integral to membrane					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		ACTGCCTTGTGACGTTGGTCT	0.512													0	0	0	0.219247	0	20	54										A	67262275	G	A	67262275	2	1	91	1	0	0	0	0	0	0	0	1	16130	1277	45	1		1	TMEM208	16	67262275	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	43543914	67262275	23092478	108	27468										
ZC3H18	124245	broad.mit.edu	37	chr16	88666210	88666211	+	Frame_Shift_Ins	INS	-	-	GC													0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aatggtaggttttaaaaaaaINSgcaactattcgaaaagaaca							TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr16:88666210_88666211insGC	uc002fky.2	+	6	1142_1143	c.942_943insGC	c.(940-945)AAAGCAfs	p.K314fs	ZC3H18_uc010voy.1_Frame_Shift_Ins_p.K197fs|ZC3H18_uc010voz.1_Frame_Shift_Ins_p.K338fs	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	314_315						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TTTTAAAAAAAGCAACTATTCG	0.431																		38	121	---	---								GC	88666211	-	GC	88666210	7	5	91	1	0	1	1	0	0	0	0	0	17565	69	3	0	960	0	ZC3H18	16	88666210	Frame_Shift_Ins	INS	-	TCGA-FT-A3EE-01A-11D-A202-08	21403935	88666210	1688543	109	27469										
ZZEF1	23140	broad.mit.edu	37	chr17	3936218	3936218	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggtctgtgaaggtggcaatGacatcacgccacagtggggc	15	9	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:3936218G>A	uc002fxe.2	-	41	6727	c.6663C>T	c.(6661-6663)GTC>GTT	p.V2221V	ZZEF1_uc002fxh.2_Silent_p.V535V|ZZEF1_uc002fxi.2_Silent_p.V456V	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2221							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGGTGGCAATGACATCACGCC	0.587													0	0	0	0.248553	0	7	14										A	3936218	G	A	3936218	2	1	91	1	0	0	0	0	0	0	0	1	18252	1277	45	1		1	ZZEF1	17	3936218	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		3936218	77258992	110	27470										
ENO3	2027	broad.mit.edu	37	chr17	4859385	4859385	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gttgagaagaaggcctgcaaCtgtctgctgctgaaggtcaa	13	8	2	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:4859385C>A	uc002gab.3	+	9	1108	c.1014C>A	c.(1012-1014)AAC>AAA	p.N338K	ENO3_uc002gac.3_Missense_Mutation_p.N338K|ENO3_uc010vss.1_Missense_Mutation_p.N295K|ENO3_uc010vst.1_Missense_Mutation_p.N165K	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	338					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						AGGCCTGCAACTGTCTGCTGC	0.597													1	0	2.4624e-09	0.204396	2.63603e-09	21	54										A	4859385	C	A	4859385	3	1	91	1	0	0	0	0	1	0	0	0	5123	564	20	4	1044	4	ENO3	17	4859385	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	923167	4859385	76335825	111	27471										
DNAH2	146754	broad.mit.edu	37	chr17	7734577	7734577	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cctctttgatactttgctttCcttgcaacctcagattacac	4	13	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:7734577C>T	uc002giu.1	+	79	12418	c.12404C>T	c.(12403-12405)TCC>TTC	p.S4135F	DNAH2_uc010cnm.1_Missense_Mutation_p.S1073F	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	4135	TPR 5.				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACTTTGCTTTCCTTGCAACCT	0.572													0	0	0	0.144211	0	32	158										T	7734577	C	T	7734577	3	4	91	1	0	0	0	0	1	0	0	0	4602	855	30	1	12718	1	DNAH2	17	7734577	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	2875192	7734577	73460633	112	27472										
MYH10	4628	broad.mit.edu	37	chr17	8417200	8417200	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gcacttagttgctgctgcttCttggcaaaggccctgaagaa	11	10	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:8417200C>T	uc002gll.2	-	20	2520	c.2424G>A	c.(2422-2424)AAG>AAA	p.K808K	MYH10_uc002glm.2_Silent_p.K839K|MYH10_uc010cnx.2_Silent_p.K817K	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	808	IQ.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GCTGCTGCTTCTTGGCAAAGG	0.458													0	0	0	0.219247	0	22	16										T	8417200	C	T	8417200	2	4	91	1	0	0	0	0	0	0	0	1	10030	912	32	1		1	MYH10	17	8417200	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	682623	8417200	72778010	113	27473										
MYH8	4626	broad.mit.edu	37	chr17	10298707	10298707	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aacttcagacttgacttggtTtaactcaagctggatacgca	8	9	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:10298707T>A	uc002gmm.2	-	34	4800	c.4705A>T	c.(4705-4707)AAC>TAC	p.N1569Y	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1569	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTGACTTGGTTTAACTCAAGC	0.393									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				0	0	0	0.234183	0	21	64										A	10298707	T	A	10298707	3	1	91	1	0	0	0	0	1	0	0	0	10041	1841	64	5	1136	5	MYH8	17	10298707	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	1881507	10298707	70896503	114	27474										
ITGA2B	3674	broad.mit.edu	37	chr17	42462976	42462976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cccgcgacagggggagtactCggcgcggcggccgctctctg	17	15	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:42462976C>T	uc002igt.1	-	4	549	c.517G>A	c.(517-519)GAG>AAG	p.E173K		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	173	Extracellular (Potential).|FG-GAP 2.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGGAGTACTCGGCGCGGCGG	0.617													0	0	0	0.217242	0	5	5										T	42462976	C	T	42462976	3	4	91	1	0	0	0	0	1	0	0	0	7876	893	31	1	2710	1	ITGA2B	17	42462976	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	32164269	42462976	38732234	115	27475										
DDX5	1655	broad.mit.edu	37	chr17	62496243	62496243	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gtataccagcagacacaaaaTtacttccaaagctcccattg	5	12	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:62496243T>C	uc002jek.2	-	13	1890	c.1643A>G	c.(1642-1644)AAT>AGT	p.N548S	DDX5_uc010deh.2_Missense_Mutation_p.N548S|DDX5_uc002jej.2_Missense_Mutation_p.N443S|DDX5_uc010wqa.1_Missense_Mutation_p.N469S	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	548					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGACACAAAATTACTTCCAAA	0.413			T	ETV4	prostate								0	0	0	0.139131	0	59	60										C	62496243	T	C	62496243	3	2	91	1	0	0	0	0	1	0	0	0	4367	1493	52	5	205	5	DDX5	17	62496243	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	20033267	62496243	18698967	116	27476										
RAB37	326624	broad.mit.edu	37	chr17	72741012	72741012	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gacccatttgggcttgacagGcggatatgagcagcgaaaga	14	8	0	3			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr17:72741012G>T	uc002jlk.2	+	7	489	c.433G>T	c.(433-435)GCG>TCG	p.A145S	RAB37_uc002jlc.2_3'UTR|RAB37_uc010dfu.2_Missense_Mutation_p.A138S|RAB37_uc002jld.2_Missense_Mutation_p.A138S|RAB37_uc010wrb.1_Missense_Mutation_p.A113S|RAB37_uc010wrc.1_Missense_Mutation_p.A150S|RAB37_uc010wrd.1_Missense_Mutation_p.A113S|RAB37_uc010wre.1_Missense_Mutation_p.A108S|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	145	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						GGCTTGACAGGCGGATATGAG	0.617											OREG0024716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.28177e-16	0.189662	9.22037e-16	20	32										T	72741012	G	T	72741012	3	4	91	1	0	0	0	0	1	0	0	0	12927	1217	42	4	762	4	RAB37	17	72741012	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	10244769	72741012	8454198	117	27477										
DSC1	1823	broad.mit.edu	37	chr18	28737511	28737511	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ctggaccggattaggctggcCgacttgagacactcctccag	12	13	0	1	rs147816863		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr18:28737511C>G	uc002kwn.2	-	3	436	c.174G>C	c.(172-174)TCG>TCC	p.S58S	DSC1_uc002kwm.2_Silent_p.S58S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	58					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTAGGCTGGCCGACTTGAGAC	0.448													0	0	0	0.11911	0	14	43										G	28737511	C	G	28737511	2	3	91	1	0	0	0	0	0	0	0	1	4765	639	23	4		4	DSC1	18	28737511	Silent	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08		28737511	49339737	118	27478										
LINGO3	645191	broad.mit.edu	37	chr19	2290209	2290209	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	caccaggatggtggtgaggtCgagcggcgcgcgcagggccg	20	11	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:2290209C>T	uc010dsx.1	-	2	1695	c.1567G>A	c.(1567-1569)GAC>AAC	p.D523N	SPPL2B_uc010dsw.1_Intron|uc002lvo.1_5'UTR	NM_001101391	NP_001094861	P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	523	Extracellular (Potential).					integral to membrane					0						GTGGTGAGGTCGAGCGGCGCG	0.716													0	0	0	0.11911	0	14	11										T	2290209	C	T	2290209	3	4	91	1	0	0	0	0	1	0	0	0	8816	884	31	1	215	1	LINGO3	19	2290209	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08		2290209	56838774	119	27479										
KHSRP	8570	broad.mit.edu	37	chr19	6418059	6418059	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agccgccttggtcacgttccCggaggatgtccatcaccatc	10	15	2	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:6418059C>T	uc002mer.3	-	10	1021	c.911G>A	c.(910-912)CGG>CAG	p.R304Q		NM_003685	NP_003676	Q92945	FUBP2_HUMAN	KH-type splicing regulatory protein	304	Gly-rich.				mRNA processing|mRNA transport|regulation of transcription, DNA-dependent|RNA splicing, via transesterification reactions|transcription, DNA-dependent	cytosol|nucleus	DNA binding|protein binding|RNA binding			skin(1)	1						GTCACGTTCCCGGAGGATGTC	0.642											OREG0025200	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.184627	0	5	21										T	6418059	C	T	6418059	3	4	91	1	0	0	0	0	1	0	0	0	8151	652	23	2	1268	2	KHSRP	19	6418059	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	4127850	6418059	52710924	120	27480										
COL5A3	50509	broad.mit.edu	37	chr19	10099815	10099815	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cctaccttcactccccgaggTccaggatagcccggagggcc	11	17	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:10099815T>C	uc002mmq.1	-	27	2216	c.2130A>G	c.(2128-2130)GGA>GGG	p.G710G		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	710	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTCCCCGAGGTCCAGGATAGC	0.542													0	0	0	0.125774	0	28	50										C	10099815	T	C	10099815	2	2	91	1	0	0	0	0	0	0	0	1	3698	1654	58	5		5	COL5A3	19	10099815	Silent	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	3681756	10099815	49029168	121	27481										
TSPAN16	26526	broad.mit.edu	37	chr19	11417292	11417292	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ctctatagctaaagtgctgtGgggtgaataactacacagat	10	7	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:11417292G>T	uc002mqv.1	+	5	613	c.463G>T	c.(463-465)GGG>TGG	p.G155W	TSPAN16_uc002mqu.1_RNA|uc002mqw.1_Intron	NM_012466	NP_036598	Q9UKR8	TSN16_HUMAN	transmembrane 4 superfamily member 16	155	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AAAGTGCTGTGGGGTGAATAA	0.438													1	0	9.04412e-07	0.099896	9.4398e-07	25	40										T	11417292	G	T	11417292	3	4	91	1	0	0	0	0	1	0	0	0	16637	1348	47	4	481	4	TSPAN16	19	11417292	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	1317477	11417292	47711691	122	27482										
NDUFA13	51079	broad.mit.edu	37	chr19	19646428	19646428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aggtcgggggcccctgcaccCgcgcgctggccacgctcaag	15	17	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:19646428C>T	uc010xqy.1	+	7	1139	c.880C>T	c.(880-882)CGC>TGC	p.R294C	YJEFN3_uc002nmt.1_Missense_Mutation_p.R212C|YJEFN3_uc010ecf.1_Missense_Mutation_p.R162C|YJEFN3_uc002nmu.1_RNA|CILP2_uc002nmv.3_5'Flank|CILP2_uc002nmw.3_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CCCCTGCACCCGCGCGCTGGC	0.706													0	0	0	0.115264	0	3	9										T	19646428	C	T	19646428	3	4	91	1	0	0	0	0	1	0	0	0	10263	652	23	2		2	NDUFA13	19	19646428	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	8229136	19646428	39482555	123	27483										
TSHZ3	57616	broad.mit.edu	37	chr19	31768141	31768141	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	acgtgtggctctctgtcaagTtcttcagcatatcggatata	9	9	4	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:31768141T>A	uc002nsy.3	-	2	2623	c.2558A>T	c.(2557-2559)AAC>ATC	p.N853I		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	853					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CTCTGTCAAGTTCTTCAGCAT	0.527													0	0	0	0.249174	0	22	91										A	31768141	T	A	31768141	3	1	91	1	0	0	0	0	1	0	0	0	16622	1725	60	5	691	5	TSHZ3	19	31768141	Missense_Mutation	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	12121713	31768141	27360842	124	27484										
MLL4	9757	broad.mit.edu	37	chr19	36229445	36229445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tggcgccaagcgctgccgtcGgttccttaactgaggccgtg	14	13	0	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:36229445G>A	uc010eei.2	+	38	8135	c.8135G>A	c.(8134-8136)CGG>CAG	p.R2712Q		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2712	Post-SET.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGCTGCCGTCGGTTCCTTAAC	0.652													0	0	0	0.248553	0	6	8										A	36229445	G	A	36229445	3	1	91	1	0	0	0	0	1	0	0	0	9623	1116	39	2	8281	2	MLL4	19	36229445	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	4461304	36229445	22899538	125	27485										
DPF1	8193	broad.mit.edu	37	chr19	38709576	38709576	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cagaggtgggcccacctgacAgtccataatggtctcctcct	10	14	1	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:38709576A>G	uc002ohl.2	-	4	529	c.502T>C	c.(502-504)TGT>CGT	p.C168R	DPF1_uc002ohm.2_Missense_Mutation_p.C168R|DPF1_uc002ohn.2_Missense_Mutation_p.C86R|DPF1_uc010xtu.1_Missense_Mutation_p.C142R|DPF1_uc010xtv.1_Missense_Mutation_p.C142R|DPF1_uc010xtw.1_Missense_Mutation_p.C142R	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	168					induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCCACCTGACAGTCCATAATG	0.657													0	0	0	0.268233	0	44	61										G	38709576	A	G	38709576	3	3	91	1	0	0	0	0	1	0	0	0	4716	188	7	5	808	5	DPF1	19	38709576	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	2480131	38709576	20419407	126	27486										
ERCC2	2068	broad.mit.edu	37	chr19	45872380	45872380	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	atactgtcttcccggtgcctGagggcatctccaggactcca	10	14	2	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:45872380G>A	uc002pbj.2	-	3	178	c.131C>T	c.(130-132)TCA>TTA	p.S44L	ERCC2_uc010ejz.2_Missense_Mutation_p.S44L|ERCC2_uc002pbk.2_Missense_Mutation_p.S20L|ERCC2_uc002pbl.3_Missense_Mutation_p.S20L|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	44	ATP (By similarity).|Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCCGGTGCCTGAGGGCATCTC	0.587			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.204396	0	18	77										A	45872380	G	A	45872380	3	1	91	1	0	0	0	0	1	0	0	0	5213	1294	45	1	2292	1	ERCC2	19	45872380	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	7162804	45872380	13256603	127	27487										
ZNF671	79891	broad.mit.edu	37	chr19	58232719	58232719	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gctgaaaagtctctcctaccTttcccacatgtgagggtctt	8	12	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr19:58232719T>C	uc002qpz.3	-	4	834	c.735A>G	c.(733-735)AAA>AAG	p.K245K	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Silent_p.K168K|ZNF671_uc010yhf.1_Silent_p.K147K	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTCTCCTACCTTTCCCACATG	0.527													0	0	0	0.132662	0	16	44										C	58232719	T	C	58232719	2	2	91	1	0	0	0	0	0	0	0	1	18075	1606	56	5		5	ZNF671	19	58232719	Silent	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	12360339	58232719	896264	128	27488										
CHGB	1114	broad.mit.edu	37	chr20	5904525	5904525	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	agaaaaagcccttctctgagGatgtgaactgggggtatgag	14	6	1	4			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:5904525G>T	uc002wmg.2	+	4	2041	c.1735G>T	c.(1735-1737)GAT>TAT	p.D579Y	CHGB_uc010zqz.1_Missense_Mutation_p.D262Y	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	579						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						CTTCTCTGAGGATGTGAACTG	0.502													1	0	4.14922e-12	0.146539	4.52888e-12	15	52										T	5904525	G	T	5904525	3	4	91	1	0	0	0	0	1	0	0	0	3339	1174	41	3	1749	3	CHGB	20	5904525	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		5904525	57120995	129	27489										
SAMHD1	25939	broad.mit.edu	37	chr20	35579911	35579911	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ggagcacacctgctccggacCccatgtcttgtagtcgggat	12	13	1	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:35579911C>T	uc002xgh.1	-	1	266	c.136G>A	c.(136-138)GGT>AGT	p.G46S		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	46	SAM.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TGCTCCGGACCCCATGTCTTG	0.652													0	0	0	0.153744	0	32	148										T	35579911	C	T	35579911	3	4	91	1	0	0	0	0	1	0	0	0	13828	623	22	2	1808	2	SAMHD1	20	35579911	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	29675386	35579911	27445609	130	27490										
PSMA7	5688	broad.mit.edu	37	chr20	60714933	60714933	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cactccacccgggccctgttGatgactatccttgcatcggc	9	16	0	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:60714933G>A	uc002ybx.1	-	3	367	c.252C>T	c.(250-252)ATC>ATT	p.I84I	PSMA7_uc002yby.1_RNA	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	84					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GGGCCCTGTTGATGACTATCC	0.597													0	0	0	0.11911	0	15	21										A	60714933	G	A	60714933	2	1	91	1	0	0	0	0	0	0	0	1	12672	1280	45	1		1	PSMA7	20	60714933	Silent	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	25135022	60714933	2310587	131	27491										
DIDO1	11083	broad.mit.edu	37	chr20	61527666	61527666	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tctgtaacttgaaacaagttAaacatctccttctcaatatg	4	9	3	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr20:61527666A>T	uc002ydr.1	-	8	2397	c.2133T>A	c.(2131-2133)TTT>TTA	p.F711L	DIDO1_uc002yds.1_Missense_Mutation_p.F711L|DIDO1_uc002ydt.1_Missense_Mutation_p.F711L|DIDO1_uc002ydu.1_Missense_Mutation_p.F711L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	711	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAAACAAGTTAAACATCTCCT	0.388													0	0	0	0.234183	0	23	56										T	61527666	A	T	61527666	3	4	91	1	0	0	0	0	1	0	0	0	4522	359	13	5	4654	5	DIDO1	20	61527666	Missense_Mutation	SNP	A	TCGA-FT-A3EE-01A-11D-A202-08	812733	61527666	1497854	132	27492										
BRWD1	54014	broad.mit.edu	37	chr21	40569194	40569194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	gcttgatcttattggcagccGtagctgcacatcttcgagta	10	10	2	1	rs145664878		TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr21:40569194G>A	uc002yxk.1	-	41	5940	c.5801C>T	c.(5800-5802)ACG>ATG	p.T1934M	BRWD1_uc010goc.1_Missense_Mutation_p.T577M|BRWD1_uc002yxl.2_Missense_Mutation_p.T1934M	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				ATTGGCAGCCGTAGCTGCACA	0.423													0	0	0	0.139131	0	56	29										A	40569194	G	A	40569194	3	1	91	1	0	0	0	0	1	0	0	0	1525	1145	40	2	1408	2	BRWD1	21	40569194	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		40569194	7560701	133	27493										
SLC35E4	339665	broad.mit.edu	37	chr22	31032724	31032724	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ggcagccctggcatgccaccGgggggcacggcgccccatgc	16	17	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chr22:31032724G>A	uc003ais.1	+	1	932	c.287G>A	c.(286-288)CGG>CAG	p.R96Q	SLC35E4_uc003ait.2_Missense_Mutation_p.R84Q	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	96						integral to membrane					0						GCATGCCACCGGGGGGCACGG	0.662													0	0	0	0.080935	0	12	3										A	31032724	G	A	31032724	3	1	91	1	0	0	0	0	1	0	0	0	14587	1116	39	2	289	2	SLC35E4	22	31032724	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		31032724	20271842	134	27494										
ARHGAP6	395	broad.mit.edu	37	chrX	11206894	11206894	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ccggggtgtttggggacgttGactcattcggtgtttctgag	16	7	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:11206894G>A	uc004cup.1	-	4	1904	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.S344L|ARHGAP6_uc004cum.1_Missense_Mutation_p.S141L|ARHGAP6_uc004cun.1_Missense_Mutation_p.S164L|ARHGAP6_uc010neb.1_Missense_Mutation_p.S166L|ARHGAP6_uc011mif.1_Missense_Mutation_p.S141L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	344	SH3-binding.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						TGGGGACGTTGACTCATTCGG	0.498													0	0	0	0.204396	0	19	40										A	11206894	G	A	11206894	3	1	91	1	0	0	0	0	1	0	0	0	887	1294	45	1	2055	1	ARHGAP6	23	11206894	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08		11206894	144063666	135	27495										
FAM47B	170062	broad.mit.edu	37	chrX	34960988	34960988	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	aggaccggccaaggtcccaaGgcatggactccaagccctgg	13	14	0	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:34960988G>A	uc004ddi.1	+	1	58	c.40G>A	c.(40-42)GGC>AGC	p.G14S		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	14										ovary(3)|breast(1)	4						AAGGTCCCAAGGCATGGACTC	0.622													0	0	0	0.184627	0	5	20										A	34960988	G	A	34960988	3	1	91	1	0	0	0	0	1	0	0	0	5570	1000	35	2	42	2	FAM47B	23	34960988	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	23754094	34960988	120309572	136	27496										
SPIN4	139886	broad.mit.edu	37	chrX	62570455	62570455	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	ttctagtccatacacactatCtttgccatcatatttaatga	3	10	3	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:62570455C>G	uc004dvf.2	-	1	764	c.244G>C	c.(244-246)GAT>CAT	p.D82H		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	82					gamete generation					ovary(1)|lung(1)	2						TACACACTATCTTTGCCATCA	0.498													0	0	0	0.150653	0	4	17										G	62570455	C	G	62570455	3	3	91	1	0	0	0	0	1	0	0	0	15055	913	32	1	509	1	SPIN4	23	62570455	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	27609467	62570455	92700105	137	27497										
MED12	9968	broad.mit.edu	37	chrX	70349240	70349240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	cccagaaccgcatcgtggatGgagccgtgtttgctgttctc	12	12	1	1			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:70349240G>A	uc004dyy.2	+	26	3851	c.3652G>A	c.(3652-3654)GGA>AGA	p.G1218R	MED12_uc011mpq.1_Missense_Mutation_p.G1218R|MED12_uc004dyz.2_Missense_Mutation_p.G1218R|MED12_uc004dza.2_Missense_Mutation_p.G1065R|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1218					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCGTGGATGGAGCCGTGTT	0.577											OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.248553	0	7	20										A	70349240	G	A	70349240	3	1	91	1	0	0	0	0	1	0	0	0	9428	1349	47	2	3754	2	MED12	23	70349240	Missense_Mutation	SNP	G	TCGA-FT-A3EE-01A-11D-A202-08	7778785	70349240	84921320	138	27498										
SMARCA1	6594	broad.mit.edu	37	chrX	128638781	128638781	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	caaaccaagaatcaaagtccTgtagaggggtggaaattctc	10	8	2	2			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:128638781T>C	uc004eun.3	-	9	1212	c.1099_splice	c.e9-1	p.D367_splice	SMARCA1_uc004eup.3_Splice_Site_p.D367_splice|SMARCA1_uc011muk.1_Splice_Site_p.D367_splice|SMARCA1_uc011mul.1_Splice_Site_p.D367_splice	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated						ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						ATCAAAGTCCTGTAGAGGGGT	0.343													0	0	0	0.083992	0	26	36										C	128638781	T	C	128638781	5	2	91	1	0	0	0	0	0	0	1	0	14768	1594	55	5	2131	5	SMARCA1	23	128638781	Splice_Site	SNP	T	TCGA-FT-A3EE-01A-11D-A202-08	58289541	128638781	26631779	139	27499										
CETN2	1069	broad.mit.edu	37	chrX	151997114	151997114	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.171428571428571	24	0.000144234949655975	2.24403998974622	2.77165653495441	2.13698735738514	0.000219932592144955	0.00114364947915377	13	tcagtcaggttctcacccaaCtccttggccacgcgtttcag	8	15	4	0			TCGA-FT-A3EE-01A-11D-A202-08	TCGA-FT-A3EE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ffdd4feb-aca3-4104-b1e8-954d705a6450	db3bb39b-a1a6-49af-aae3-7cb489a724e4	g.chrX:151997114C>A	uc004fgq.2	-	4	443	c.396G>T	c.(394-396)GAG>GAT	p.E132D	CETN2_uc004fgr.2_Missense_Mutation_p.E61D|NSDHL_uc004fgt.1_5'Flank|NSDHL_uc004fgs.1_5'Flank	NM_004344	NP_004335	P41208	CETN2_HUMAN	caltractin	132	EF-hand 3.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCACCCAACTCCTTGGCCA	0.418								Direct_reversal_of_damage|NER					1	0	1.68575e-08	0.125774	1.79313e-08	28	35										A	151997114	C	A	151997114	3	1	91	1	0	0	0	0	1	0	0	0	3275	564	20	4	130	4	CETN2	23	151997114	Missense_Mutation	SNP	C	TCGA-FT-A3EE-01A-11D-A202-08	23358333	151997114	3273446	140	27500										
ACAP3	116983	broad.mit.edu	37	chr1	1233261	1233261	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggcgatgctggcctgcacagCctggacccaggcttgccgca	14	15	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:1233261C>T	uc001aeb.2	-	14	1143	c.1069G>A	c.(1069-1071)GCT>ACT	p.A357T	ACAP3_uc001ady.2_Missense_Mutation_p.A87T|ACAP3_uc001aea.2_Missense_Mutation_p.A315T	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	357	PH.				filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						GCCTGCACAGCCTGGACCCAG	0.687													0	0	0	0.007413	0	18	22										T	1233261	C	T	1233261	3	4	92	1	0	0	0	0	1	0	0	0	120	739	26	2	1479	2	ACAP3	1	1233261	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		1233261	248017360	1	27501										
RER1	11079	broad.mit.edu	37	chr1	2327262	2327262	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gacagtgtgggagaatccgtCcatgggaaaccttcggtggt	15	8	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:2327262C>T	uc001aje.1	+	2	224	c.33C>T	c.(31-33)GTC>GTT	p.V11V	RER1_uc001ajf.1_Silent_p.V11V	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	11					retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		GAGAATCCGTCCATGGGAAAC	0.418													0	0	0	0.004482	0	8	37										T	2327262	C	T	2327262	2	4	92	1	0	0	0	0	0	0	0	1	13230	842	30	1		1	RER1	1	2327262	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1094001	2327262	246923359	2	27502										
MTHFR	4524	broad.mit.edu	37	chr1	11854051	11854051	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	atgttgggctgtgagttgatGgtgaggatgccctggcggtt	18	5	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:11854051G>A	uc001atc.1	-	9	1627	c.1443C>T	c.(1441-1443)ACC>ACT	p.T481T	MTHFR_uc001atb.1_Silent_p.T504T	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	481					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	GTGAGTTGATGGTGAGGATGC	0.652													0	0	0	0.007291	0	26	61										A	11854051	G	A	11854051	2	1	92	1	0	0	0	0	0	0	0	1	9931	1335	47	2		2	MTHFR	1	11854051	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	9526789	11854051	237396570	3	27503										
WDTC1	23038	broad.mit.edu	37	chr1	27623546	27623546	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tatctcctgccagaagtccaGaatggcaagatgtccaccaa	8	12	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:27623546G>C	uc009vst.2	+	11	1492	c.957G>C	c.(955-957)CAG>CAC	p.Q319H	WDTC1_uc001bno.2_Missense_Mutation_p.Q318H|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_5'UTR	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	319							protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CAGAAGTCCAGAATGGCAAGA	0.463											OREG0013279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	45										C	27623546	G	C	27623546	3	2	92	1	0	0	0	0	1	0	0	0	17339	933	33	1	992	1	WDTC1	1	27623546	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	15769495	27623546	221627075	4	27504										
USP24	23358	broad.mit.edu	37	chr1	55638085	55638085	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caggagaccagtgggaattgGatcttgttttattctctctg	11	7	3	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:55638085G>C	uc001cyg.3	-	3	331	c.331C>G	c.(331-333)CCA>GCA	p.P111A		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	223					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GTGGGAATTGGATCTTGTTTT	0.358													0	0	0	0.014758	0	4	13										C	55638085	G	C	55638085	3	2	92	1	0	0	0	0	1	0	0	0	17052	1174	41	1	7455	1	USP24	1	55638085	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	28014539	55638085	193612536	5	27505										
C8A	731	broad.mit.edu	37	chr1	57351743	57351743	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tatggcatgtatgccaagttCatcaatgactatggcaccca	8	10	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:57351743C>T	uc001cyo.2	+	7	1131	c.999C>T	c.(997-999)TTC>TTT	p.F333F		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	333	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						ATGCCAAGTTCATCAATGACT	0.398													0	0	0	0.014323	0	24	38										T	57351743	C	T	57351743	2	4	92	1	0	0	0	0	0	0	0	1	2416	825	29	1		1	C8A	1	57351743	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1713658	57351743	191898878	6	27506										
ATXN7L2	127002	broad.mit.edu	37	chr1	110029160	110029160	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcgggcactgccctgcccatGatgacttctacttggttgtg	11	12	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:110029160G>A	uc001dxr.2	+	3	241	c.226G>A	c.(226-228)GAT>AAT	p.D76N	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	76										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCCTGCCCATGATGACTTCTA	0.542													0	0	0	0.016723	0	13	24										A	110029160	G	A	110029160	3	1	92	1	0	0	0	0	1	0	0	0	1217	1290	45	1	236	1	ATXN7L2	1	110029160	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	52677417	110029160	139221461	7	27507										
ATXN7L2	127002	broad.mit.edu	37	chr1	110029717	110029717	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tctcagaaatgccatgtagtGaatgggcagggcccagcttg	13	9	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:110029717G>C	uc001dxr.2	+	4	402	c.387G>C	c.(385-387)GTG>GTC	p.V129V	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	129										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GCCATGTAGTGAATGGGCAGG	0.637													0	0	0	0.00308	0	8	7										C	110029717	G	C	110029717	2	2	92	1	0	0	0	0	0	0	0	1	1217	1277	45	1		1	ATXN7L2	1	110029717	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	557	110029717	139220904	8	27508										
NOTCH2	4853	broad.mit.edu	37	chr1	120510124	120510124	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catcattctggcaggggtctGaatggcactcattgatgtcc	11	10	4	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:120510124G>C	uc001eik.2	-	8	1641	c.1385C>G	c.(1384-1386)TCA>TGA	p.S462*	NOTCH2_uc001eil.2_Nonsense_Mutation_p.S462*|NOTCH2_uc001eim.3_Nonsense_Mutation_p.S379*	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	462	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGGGGTCTGAATGGCACTC	0.507			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.016723	0	14	72										C	120510124	G	C	120510124	4	2	92	1	0	0	0	0	0	1	0	0	10548	1294	45	1	6138	1	NOTCH2	1	120510124	Nonsense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	10480407	120510124	128740497	9	27509										
TXNIP	10628	broad.mit.edu	37	chr1	145438899	145438900	+	Frame_Shift_Ins	INS	-	-	T													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggtggctggccgggtgatagINStggaggtgtgtgaagttact							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:145438899_145438900insT	uc001enn.3	+	1	438_439	c.97_98insT	c.(97-99)GTGfs	p.V33fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_5'Flank	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	33					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCGGGTGATAGTGGAGGTGTGT	0.515																		7	31	---	---								T	145438900	-	T	145438899	7	5	92	1	0	1	1	0	0	0	0	0	16800	1029	36	0	99	0	TXNIP	1	145438899	Frame_Shift_Ins	INS	-	TCGA-G2-A2EC-01A-11D-A17V-08	24928775	145438899	103811722	10	27510										
C1orf104	284618	broad.mit.edu	37	chr1	155290718	155290718	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcccctcccgctctgtgcccCgccgggcggggaccgtggga	15	18	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:155290718C>T	uc001fki.2	-	2	839	c.562G>A	c.(562-564)GGG>AGG	p.G188R	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'UTR|RUSC1_uc001fkk.2_5'UTR|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	188											0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CTCTGTGCCCCGCCGGGCGGG	0.726													0	0	0	0.004672	0	3	11										T	155290718	C	T	155290718	3	4	92	1	0	0	0	0	1	0	0	0	1978	652	23	2	152	2	C1orf104	1	155290718	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	9851819	155290718	93959903	11	27511										
VSIG8	391123	broad.mit.edu	37	chr1	159825827	159825827	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caggcagcccagcgcgagcaGagagcccaggacgatgccga	15	14	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:159825827G>A	uc001fuh.2	-	6	953	c.817C>T	c.(817-819)CTG>TTG	p.L273L	C1orf204_uc001fuf.1_5'Flank|C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	273	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					AGCGCGAGCAGAGAGCCCAGG	0.468													0	0	0	0.006214	0	8	8										A	159825827	G	A	159825827	2	1	92	1	0	0	0	0	0	0	0	1	17223	933	33	1		1	VSIG8	1	159825827	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	4535109	159825827	89424794	12	27512										
PRG4	10216	broad.mit.edu	37	chr1	186276451	186276451	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccaagtctgcacccaccactAccaaggagcctgcacccacc	6	20	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:186276451A>C	uc001gru.3	+	7	1651	c.1600A>C	c.(1600-1602)ACC>CCC	p.T534P	PRG4_uc001grt.3_Missense_Mutation_p.T493P|PRG4_uc009wyl.2_Missense_Mutation_p.T441P|PRG4_uc009wym.2_Missense_Mutation_p.T400P|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	534	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|24; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACCCACCACTACCAAGGAGCC	0.632													0	0	0	0.013537	0	7	51										C	186276451	A	C	186276451	3	2	92	1	0	0	0	0	1	0	0	0	12481	391	14	5	1622	5	PRG4	1	186276451	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	26450624	186276451	62974170	13	27513										
CFH	3075	broad.mit.edu	37	chr1	196697596	196697596	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagatgtagaggaaaagaagGatggatacacacagtctgca	12	6	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:196697596G>T	uc001gtj.3	+	15	2597	c.2357G>T	c.(2356-2358)GGA>GTA	p.G786V		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	786	Sushi 13.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGAAAAGAAGGATGGATACAC	0.318													1	0	0.000442599	0.006214	0.000452892	9	25										T	196697596	G	T	196697596	3	4	92	1	0	0	0	0	1	0	0	0	3283	1174	41	3	2433	3	CFH	1	196697596	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	10421145	196697596	52553025	14	27514										
CR1L	1379	broad.mit.edu	37	chr1	207850763	207850763	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	atgtcccggaatggcttccaTttgccaggcctaccaaccta	8	14	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:207850763T>A	uc001hga.3	+	2	248	c.127T>A	c.(127-129)TTT>ATT	p.F43I	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	43	Sushi 1.					cytoplasm|extracellular region|membrane					0						ATGGCTTCCATTTGCCAGGCC	0.413													0	0	0	0.004482	0	8	61										A	207850763	T	A	207850763	3	1	92	1	0	0	0	0	1	0	0	0	3841	1493	52	5	133	5	CR1L	1	207850763	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	11153167	207850763	41399858	15	27515										
KCNH1	3756	broad.mit.edu	37	chr1	211192470	211192470	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gggaccaagatggctgtataGaaggtcaagatcaagatgat	13	5	2	5			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:211192470G>A	uc001hib.2	-	6	857	c.687C>T	c.(685-687)TTC>TTT	p.F229F	KCNH1_uc001hic.2_Silent_p.F229F	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	229	Helical; Name=Segment S1; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TGGCTGTATAGAAGGTCAAGA	0.438													0	0	0	0.006122	0	18	33										A	211192470	G	A	211192470	2	1	92	1	0	0	0	0	0	0	0	1	8031	933	33	1		1	KCNH1	1	211192470	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	3341707	211192470	38058151	16	27516										
CAPN9	10753	broad.mit.edu	37	chr1	230903408	230903408	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccgagaacttctatgagattCtagagaaggctttgaagaga	11	6	2	5	rs147002278		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr1:230903408C>T	uc001htz.1	+	5	771	c.658C>T	c.(658-660)CTA>TTA	p.L220L	CAPN9_uc009xfg.1_Silent_p.L157L|CAPN9_uc001hua.1_Silent_p.L220L	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	220	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CTATGAGATTCTAGAGAAGGC	0.547													0	0	0	0.004007	0	15	65										T	230903408	C	T	230903408	2	4	92	1	0	0	0	0	0	0	0	1	2632	912	32	1		1	CAPN9	1	230903408	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	19710938	230903408	18347213	17	27517										
C2orf43	60526	broad.mit.edu	37	chr2	20901362	20901362	+	Missense_Mutation	SNP	C	C	T													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctcctttatggtttcgtcatCtctcttcaccacctccatca							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:20901362C>T	uc002rec.2	-	6	787	c.754G>A	c.(754-756)GAT>AAT	p.D252N	C2orf43_uc002rea.1_Missense_Mutation_p.D252N|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_3'UTR|C2orf43_uc010ykb.1_Missense_Mutation_p.D122N|C2orf43_uc010ykc.1_Missense_Mutation_p.D204N|C2orf43_uc010ykd.1_3'UTR|C2orf43_uc010yke.1_Missense_Mutation_p.D210N|C2orf43_uc010ykf.1_Missense_Mutation_p.D122N	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	252											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTTCGTCATCTCTCTTCACC	0.383													0	0	0	0.013114	0	40	125										T	20901362	C	T	20901362	3	4	92	1	0	0	0	0	1	0	0	0	2167	913	32	1	231	1	C2orf43	2	20901362	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		20901362	222298011	18	27518	135	2								
C2orf43	60526	broad.mit.edu	37	chr2	20901369	20901369	+	Silent	SNP	C	C	T													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	atggtttcgtcatctctcttCaccacctccatcatttcttg							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:20901369C>T	uc002rec.2	-	6	780	c.747G>A	c.(745-747)GTG>GTA	p.V249V	C2orf43_uc002rea.1_Silent_p.V249V|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_3'UTR|C2orf43_uc010ykb.1_Silent_p.V119V|C2orf43_uc010ykc.1_Silent_p.V201V|C2orf43_uc010ykd.1_3'UTR|C2orf43_uc010yke.1_Silent_p.V207V|C2orf43_uc010ykf.1_Silent_p.V119V	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	249											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATCTCTCTTCACCACCTCCA	0.373													0	0	0	0.011902	0	41	127										T	20901369	C	T	20901369	2	4	92	1	0	0	0	0	0	0	0	1	2167	813	29	1		1	C2orf43	2	20901369	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	7	20901369	222298004	19	27519	135	2								
NCOA1	8648	broad.mit.edu	37	chr2	24930108	24930108	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agataacaaagagattgcctCaattttaaatgaaatgattc	6	5	1	4			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:24930108C>G	uc002rfk.2	+	11	2027	c.1769C>G	c.(1768-1770)TCA>TGA	p.S590*	NCOA1_uc010eye.2_Nonsense_Mutation_p.S590*|NCOA1_uc002rfi.2_Nonsense_Mutation_p.S439*|NCOA1_uc002rfj.2_Nonsense_Mutation_p.S590*|NCOA1_uc002rfl.2_Nonsense_Mutation_p.S590*	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	590	Ser-rich.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGATTGCCTCAATTTTAAAT	0.408			T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.00308	0	7	46										G	24930108	C	G	24930108	4	3	92	1	0	0	0	0	0	1	0	0	10228	838	29	1	1803	1	NCOA1	2	24930108	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	4028739	24930108	218269265	20	27520										
B3GNT2	10678	broad.mit.edu	37	chr2	62449660	62449673	+	Frame_Shift_Del	DEL	TCACGTCGGTGGTT	TCACGTCGGTGGTT	-													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctgcgaacctgacctgagggTcacgtcggtggttacgggtt					rs72893877	byFrequency	TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:62449660_62449673delTCACGTCGGTGGTT	uc002sbs.2	+	2	543_556	c.305_318delTCACGTCGGTGGTT	c.(304-318)GTCACGTCGGTGGTTfs	p.V102fs		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	102_106	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GACCTGAGGGTCACGTCGGTGGTTACGGGTTTTA	0.5																		21	332	---	---								-	62449673	TCACGTCGGTGGTT	-	62449660	7	5	92	1	0	1	0	1	0	0	0	0	1257	1667	58	0	307	0	B3GNT2	2	62449660	Frame_Shift_Del	DEL	TCACGTCGGTGGTT	TCGA-G2-A2EC-01A-11D-A17V-08	37519552	62449660	180749713	21	27521										
FAHD2B	151313	broad.mit.edu	37	chr2	97757424	97757424	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcagagctgtgagtaatcttCttctaccagacaccagcatc	8	12	3	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:97757424C>T	uc002sxm.2	-	2	171	c.20G>A	c.(19-21)AGA>AAA	p.R7K		NM_199336	NP_955368	Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing	7							hydrolase activity|metal ion binding				0						GAGTAATCTTCTTCTACCAGA	0.547													0	0	0	0.007413	0	20	50										T	97757424	C	T	97757424	3	4	92	1	0	0	0	0	1	0	0	0	5374	913	32	1	952	1	FAHD2B	2	97757424	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	35307764	97757424	145441949	22	27522										
MYO7B	4648	broad.mit.edu	37	chr2	128393891	128393891	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccttcggatccgccttcttcGaggtgaaggtaaaccttgcc	10	13	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:128393891G>C	uc002top.2	+	44	6090	c.6037G>C	c.(6037-6039)GAG>CAG	p.E2013Q	MYO7B_uc002tos.1_Missense_Mutation_p.E123Q|MYO7B_uc002tot.2_Missense_Mutation_p.E123Q	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2013	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGCCTTCTTCGAGGTGAAGGT	0.612													0	0	0	0.008291	0	11	26										C	128393891	G	C	128393891	3	2	92	1	0	0	0	0	1	0	0	0	10083	1059	37	1	6207	1	MYO7B	2	128393891	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	30636467	128393891	114805482	23	27523										
LRP1B	53353	broad.mit.edu	37	chr2	141283479	141283479	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtcgcatatccaggttggcaGaacacacagtgaggtagaat	12	8	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:141283479G>T	uc002tvj.1	-	49	8932	c.7960C>A	c.(7960-7962)CTG>ATG	p.L2654M		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2654	Extracellular (Potential).|LDL-receptor class A 14.			LP -> CQ (in Ref. 2; AAL38108).	protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGGTTGGCAGAACACACAGT	0.403										TSP Lung(27;0.18)			1	0	3.07112e-06	0.010729	3.19203e-06	12	37										T	141283479	G	T	141283479	3	4	92	1	0	0	0	0	1	0	0	0	8955	933	33	3	6011	3	LRP1B	2	141283479	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	12889588	141283479	101915894	24	27524										
TTN	7273	broad.mit.edu	37	chr2	179415741	179415741	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagaagactgtgagggcgggCttatagttccaacagcattt	12	8	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:179415741C>A	uc010zfg.1	-	285	84037	c.83813G>T	c.(83812-83814)AGC>ATC	p.S27938I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S21633I|TTN_uc010zfi.1_Missense_Mutation_p.S21566I|TTN_uc010zfj.1_Missense_Mutation_p.S21441I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28865							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGGGCGGGCTTATAGTTCC	0.388													1	0	0.000602214	0.014758	0.00061384	5	20										A	179415741	C	A	179415741	3	1	92	1	0	0	0	0	1	0	0	0	16732	797	28	4	16570	4	TTN	2	179415741	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	38132262	179415741	63783632	25	27525										
TTN	7273	broad.mit.edu	37	chr2	179464145	179464145	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctgaaacagattcaaattttAtgggtcccactggagggcca	10	9	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:179464145A>T	uc010zfg.1	-	239	48895	c.48671T>A	c.(48670-48672)ATA>AAA	p.I16224K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I9919K|TTN_uc010zfi.1_Missense_Mutation_p.I9852K|TTN_uc010zfj.1_Missense_Mutation_p.I9727K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17151							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAAATTTTATGGGTCCCAC	0.363													0	0	0	0.013537	0	13	35										T	179464145	A	T	179464145	3	4	92	1	0	0	0	0	1	0	0	0	16732	449	16	5	51610	5	TTN	2	179464145	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	48404	179464145	63735228	26	27526										
ZSWIM2	151112	broad.mit.edu	37	chr2	187713754	187713754	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agccagtggggcccatctctCgtaggaggtagatgctgcta	14	10	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:187713754C>G	uc002upu.1	-	1	144	c.104G>C	c.(103-105)CGA>CCA	p.R35P		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	35					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GCCCATCTCTCGTAGGAGGTA	0.597													0	0	0	0.006214	0	10	25										G	187713754	C	G	187713754	3	3	92	1	0	0	0	0	1	0	0	0	18238	884	31	1	1833	1	ZSWIM2	2	187713754	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	8249609	187713754	55485619	27	27527										
ICA1L	130026	broad.mit.edu	37	chr2	203653802	203653802	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caatgaatctacaggtagatCttttgcaactattgagtgta	8	6	2	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:203653802C>G	uc002uzh.1	-	12	1158	c.994G>C	c.(994-996)GAT>CAT	p.D332H	ICA1L_uc002uzi.1_Missense_Mutation_p.D332H	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	332											0						ACAGGTAGATCTTTTGCAACT	0.323													0	0	0	0.003163	0	14	39										G	203653802	C	G	203653802	3	3	92	1	0	0	0	0	1	0	0	0	7478	913	32	1	466	1	ICA1L	2	203653802	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	15940048	203653802	39545571	28	27528										
SGPP2	130367	broad.mit.edu	37	chr2	223423425	223423425	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtgggaattgtgttgatcctCttggttcgtcagcttgtaca	12	7	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:223423425C>G	uc010zlo.1	+	5	1008	c.1008C>G	c.(1006-1008)CTC>CTG	p.L336L	SGPP2_uc010zlp.1_Silent_p.L208L	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	336	Helical; (Potential).				sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TGTTGATCCTCTTGGTTCGTC	0.473													0	0	0	0.020292	0	14	52										G	223423425	C	G	223423425	2	3	92	1	0	0	0	0	0	0	0	1	14220	900	32	1		1	SGPP2	2	223423425	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	19769623	223423425	19775948	29	27529										
SCG2	7857	broad.mit.edu	37	chr2	224463700	224463700	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttcactcagtgaatccctctCgggcaagtggctttcatcgc	9	13	4	1	rs137998511		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr2:224463700C>G	uc002vnm.2	-	2	434	c.301G>C	c.(301-303)GAG>CAG	p.E101Q		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	101					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GAATCCCTCTCGGGCAAGTGG	0.453													0	0	0	0.021523	0	26	51										G	224463700	C	G	224463700	3	3	92	1	0	0	0	0	1	0	0	0	13891	893	31	1	1556	1	SCG2	2	224463700	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1040275	224463700	18735673	30	27530										
SRGAP3	9901	broad.mit.edu	37	chr3	9146379	9146379	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cctacctttttgaagagtctGatgacatcctcactgatctg	7	11	3	5			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:9146379G>A	uc003brf.1	-	3	1084	c.408C>T	c.(406-408)ATC>ATT	p.I136I	SRGAP3_uc003brg.1_Silent_p.I136I|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brk.2_Silent_p.I136I	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	136					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TGAAGAGTCTGATGACATCCT	0.552			T	RAF1	pilocytic astrocytoma								0	0	0	0.00632	0	28	65										A	9146379	G	A	9146379	2	1	92	1	0	0	0	0	0	0	0	1	15146	1280	45	1		1	SRGAP3	3	9146379	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		9146379	188876051	31	27531										
GALNTL2	117248	broad.mit.edu	37	chr3	16254202	16254202	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggaacagggttcgcattgctGagacctggctggggtcattc	15	9	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:16254202G>A	uc003car.3	+	6	1799	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	GALNTL2_uc003caq.3_Missense_Mutation_p.E175K	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	442	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						TCGCATTGCTGAGACCTGGCT	0.547													0	0	0	0.003163	0	13	52										A	16254202	G	A	16254202	3	1	92	1	0	0	0	0	1	0	0	0	6222	1291	45	1	1346	1	GALNTL2	3	16254202	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	7107823	16254202	181768228	32	27532										
EPM2AIP1	9852	broad.mit.edu	37	chr3	37033451	37033451	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cacaaagccattgtttgtctGagaagtggactgttgttgcc	11	8	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:37033451G>C	uc003cgk.2	-	1	1345	c.1118C>G	c.(1117-1119)TCA>TGA	p.S373*	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	373						endoplasmic reticulum					0						TTGTTTGTCTGAGAAGTGGAC	0.398													0	0	0	0.01441	0	54	124										C	37033451	G	C	37033451	4	2	92	1	0	0	0	0	0	1	0	0	5184	1294	45	1	709	1	EPM2AIP1	3	37033451	Nonsense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	20779249	37033451	160988979	33	27533										
NKTR	4820	broad.mit.edu	37	chr3	42680225	42680225	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaagcataaggctccaaaacGaaagcaagcatttcactggc	8	10	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:42680225G>A	uc003clo.2	+	13	3176	c.3029G>A	c.(3028-3030)CGA>CAA	p.R1010Q	NKTR_uc003clm.1_Missense_Mutation_p.R757Q|NKTR_uc003clp.2_Missense_Mutation_p.R757Q|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R900Q|NKTR_uc003clr.1_Missense_Mutation_p.R757Q|NKTR_uc003cls.2_Missense_Mutation_p.R710Q	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1010	Arg/Lys-rich (basic).				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GCTCCAAAACGAAAGCAAGCA	0.383													0	0	0	0.010729	0	10	42										A	42680225	G	A	42680225	3	1	92	1	0	0	0	0	1	0	0	0	10448	1058	37	1	3075	1	NKTR	3	42680225	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	5646774	42680225	155342205	34	27534										
ZNF445	353274	broad.mit.edu	37	chr3	44497015	44497015	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gactgggcctgagctggataGgcagcatgccacctgcctgg	15	12	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:44497015G>T	uc003cnf.2	-	3	375	c.27C>A	c.(25-27)GCC>GCA	p.A9A	ZNF445_uc011azv.1_Silent_p.A9A|ZNF445_uc011azw.1_Silent_p.A9A	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	9					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GAGCTGGATAGGCAGCATGCC	0.557													1	0	2.17888e-05	0.006214	2.24697e-05	10	47										T	44497015	G	T	44497015	2	4	92	1	0	0	0	0	0	0	0	1	17915	987	35	4		4	ZNF445	3	44497015	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1816790	44497015	153525415	35	27535										
C3orf62	375341	broad.mit.edu	37	chr3	49308828	49308828	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catgtggttcaattcgttttCaaattctatttttccagcca	5	9	3	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:49308828C>G	uc003cwn.2	-	3	792	c.589G>C	c.(589-591)GAA>CAA	p.E197Q	C3orf62_uc003cwm.2_Missense_Mutation_p.E46Q|hsa-mir-4271|MI0015879_5'Flank	NM_198562	NP_940964	Q6ZUJ4	CC062_HUMAN	hypothetical protein LOC375341	197											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AATTCGTTTTCAAATTCTATT	0.423													0	0	0	0.008291	0	11	55										G	49308828	C	G	49308828	3	3	92	1	0	0	0	0	1	0	0	0	2238	835	29	1	218	1	C3orf62	3	49308828	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	4811813	49308828	148713602	36	27536										
AMIGO3	386724	broad.mit.edu	37	chr3	49756821	49756821	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttgtggagcgcacggggcggGaaaccctcggagtccggggt	19	10	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:49756821G>T	uc003cxj.2	-	1	418	c.78C>A	c.(76-78)TTC>TTA	p.F26L	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	26	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CACGGGGCGGGAAACCCTCGG	0.642											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	9.31168e-06	0.016723	9.64033e-06	13	37										T	49756821	G	T	49756821	3	4	92	1	0	0	0	0	1	0	0	0	577	1165	41	3	1440	3	AMIGO3	3	49756821	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	447993	49756821	148265609	37	27537										
DOCK3	1795	broad.mit.edu	37	chr3	51317569	51317569	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcctgccttctctcactgctCcgccagatgtgtgacaccca	7	17	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:51317569C>T	uc011bds.1	+	27	2879	c.2856C>T	c.(2854-2856)CTC>CTT	p.L952L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	952						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTCACTGCTCCGCCAGATGT	0.517													0	0	0	0.009096	0	3	25										T	51317569	C	T	51317569	2	4	92	1	0	0	0	0	0	0	0	1	4688	842	30	1		1	DOCK3	3	51317569	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1560748	51317569	146704861	38	27538										
DNAH1	25981	broad.mit.edu	37	chr3	52398976	52398976	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggaggaggacacggactacgGcatcctggatgaggccatcc	15	11	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:52398976G>A	uc011bef.1	+	34	5720	c.5459G>A	c.(5458-5460)GGC>GAC	p.G1820D		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1820					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACGGACTACGGCATCCTGGAT	0.607													0	0	0	0.004007	0	14	63										A	52398976	G	A	52398976	3	1	92	1	0	0	0	0	1	0	0	0	4597	1203	42	2	5589	2	DNAH1	3	52398976	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1081407	52398976	145623454	39	27539										
TFG	10342	broad.mit.edu	37	chr3	100467340	100467340	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtaaccgtcctccctttggtCagggctatacccaacctgga	9	14	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:100467340C>T	uc003due.2	+	8	1617	c.1168C>T	c.(1168-1170)CAG>TAG	p.Q390*	TFG_uc003duf.2_Nonsense_Mutation_p.Q390*|TFG_uc003dug.2_Nonsense_Mutation_p.Q386*|TFG_uc003duh.2_Nonsense_Mutation_p.Q386*|TFG_uc003dui.2_Nonsense_Mutation_p.Q390*	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	390					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						TCCCTTTGGTCAGGGCTATAC	0.498			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	0.013537	0	11	48										T	100467340	C	T	100467340	4	4	92	1	0	0	0	0	0	1	0	0	15803	827	29	1	1194	1	TFG	3	100467340	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	48068364	100467340	97555090	40	27540										
CBLB	868	broad.mit.edu	37	chr3	105459361	105459361	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccttccctgctgccatcaatCagggcttgaaataagggctt	9	12	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:105459361C>G	uc003dwc.2	-	7	1282	c.960G>C	c.(958-960)CTG>CTC	p.L320L	CBLB_uc011bhi.1_Silent_p.L342L|CBLB_uc003dwd.1_Silent_p.L320L|CBLB_uc003dwe.1_Silent_p.L320L|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	320	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGCCATCAATCAGGGCTTGAA	0.418			Mis S		AML								0	0	0	0.012319	0	20	50										G	105459361	C	G	105459361	2	3	92	1	0	0	0	0	0	0	0	1	2701	813	29	1		1	CBLB	3	105459361	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	4992021	105459361	92563069	41	27541										
DPPA4	55211	broad.mit.edu	37	chr3	109056349	109056349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctccatacttgtagaagaagCggagcctcgcaacatgcttc	9	12	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:109056349C>T	uc003dxq.3	-	1	71	c.16G>A	c.(16-18)GCT>ACT	p.A6T	DPPA4_uc011bho.1_Missense_Mutation_p.A6T|DPPA4_uc011bhp.1_Missense_Mutation_p.A6T	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	6						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GTAGAAGAAGCGGAGCCTCGC	0.493													0	0	0	0.004482	0	9	32										T	109056349	C	T	109056349	3	4	92	1	0	0	0	0	1	0	0	0	4736	768	27	2	926	2	DPPA4	3	109056349	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3596988	109056349	88966081	42	27542										
POLQ	10721	broad.mit.edu	37	chr3	121228970	121228970	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggcctcaatcgctccaagctGaacagactcttgatttctct	7	13	3	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:121228970G>A	uc003eee.3	-	11	1861	c.1732C>T	c.(1732-1734)CAG>TAG	p.Q578*		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	578					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		GCTCCAAGCTGAACAGACTCT	0.428								DNA_polymerases_(catalytic_subunits)					0	0	0	0.012319	0	23	62										A	121228970	G	A	121228970	4	1	92	1	0	0	0	0	0	1	0	0	12208	1299	45	1	6120	1	POLQ	3	121228970	Nonsense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	12172621	121228970	76793460	43	27543										
PLCH1	23007	broad.mit.edu	37	chr3	155199036	155199036	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctggggtttggaactttctgCttgttggcttcctgtttctc	11	9	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:155199036C>T	uc011bok.1	-	23	5080	c.4803G>A	c.(4801-4803)AAG>AAA	p.K1601K	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Silent_p.K1563K	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1601					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAACTTTCTGCTTGTTGGCTT	0.547													0	0	0	0.004656	0	28	52										T	155199036	C	T	155199036	2	4	92	1	0	0	0	0	0	0	0	1	12037	796	28	2		2	PLCH1	3	155199036	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	33970066	155199036	42823394	44	27544										
PLCH1	23007	broad.mit.edu	37	chr3	155199541	155199541	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caccctgataggctagataaGaaatactttgagttttgaca	8	7	0	5			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:155199541G>C	uc011bok.1	-	23	4575	c.4298C>G	c.(4297-4299)TCT>TGT	p.S1433C	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.S1395C	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1433					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGCTAGATAAGAAATACTTTG	0.413													0	0	0	0.004656	0	28	46										C	155199541	G	C	155199541	3	2	92	1	0	0	0	0	1	0	0	0	12037	942	33	1	787	1	PLCH1	3	155199541	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	505	155199541	42822889	45	27545										
ACTL6A	86	broad.mit.edu	37	chr3	179294032	179294032	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aatggtcgttctactgggctGattttggacagtggagccac	13	8	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:179294032G>A	uc003fjw.2	+	6	677	c.504G>A	c.(502-504)CTG>CTA	p.L168L	ACTL6A_uc003fjx.2_Silent_p.L126L|ACTL6A_uc003fjy.2_Silent_p.L126L	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	168					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			CTACTGGGCTGATTTTGGACA	0.398													0	0	0	0.004007	0	13	26										A	179294032	G	A	179294032	2	1	92	1	0	0	0	0	0	0	0	1	198	1277	45	1		1	ACTL6A	3	179294032	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	24094491	179294032	18728398	46	27546										
ACTL6A	86	broad.mit.edu	37	chr3	179294656	179294656	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcaaactggaaaagaaaagaGaagttgcctcaggttacgag	12	6	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:179294656G>C	uc003fjw.2	+	8	896	c.723G>C	c.(721-723)GAG>GAC	p.E241D	ACTL6A_uc003fjx.2_Missense_Mutation_p.E199D|ACTL6A_uc003fjy.2_Missense_Mutation_p.E199D	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	241					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			AAAGAAAAGAGAAGTTGCCTC	0.418													0	0	0	0.00632	0	28	54										C	179294656	G	C	179294656	3	2	92	1	0	0	0	0	1	0	0	0	198	933	33	1	753	1	ACTL6A	3	179294656	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	624	179294656	18727774	47	27547										
RTP1	132112	broad.mit.edu	37	chr3	186917517	186917517	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcatgctggaggagaacatcGagggcctggtggacaacctc	15	10	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr3:186917517G>A	uc003frg.2	+	2	481	c.451G>A	c.(451-453)GAG>AAG	p.E151K		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	151	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GGAGAACATCGAGGGCCTGGT	0.682													0	0	0	0.014758	0	5	31										A	186917517	G	A	186917517	3	1	92	1	0	0	0	0	1	0	0	0	13733	1059	37	1	457	1	RTP1	3	186917517	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	7622861	186917517	11104913	48	27548										
SH3TC1	54436	broad.mit.edu	37	chr4	8214432	8214432	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccgtctgcccctccagacctGaccctgcagctgctggctgt	10	18	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:8214432G>C	uc003gkv.3	+	4	353	c.252G>C	c.(250-252)CTG>CTC	p.L84L	SH3TC1_uc003gkw.3_Silent_p.L8L|SH3TC1_uc003gkx.3_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	84							binding			large_intestine(2)|pancreas(1)	3						CTCCAGACCTGACCCTGCAGC	0.662													0	0	0	0.001984	0	7	23										C	8214432	G	C	8214432	2	2	92	1	0	0	0	0	0	0	0	1	14261	1277	45	1		1	SH3TC1	4	8214432	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		8214432	182939844	49	27549										
CENPC1	1060	broad.mit.edu	37	chr4	68358626	68358627	+	Frame_Shift_Ins	INS	-	-	T													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagatccttttcttattagaINSttttttgttgacttttccaa							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:68358626_68358627insT	uc003hdd.1	-	15	2562_2563	c.2379_2380insA	c.(2377-2382)AAATCTfs	p.K793fs	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihl.2_5'UTR	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	793_794	Nuclear localization signal (Potential).				mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						TTCTTATTAGATTTTTTGTTGA	0.297																		2	4	---	---								T	68358627	-	T	68358626	7	5	92	1	0	1	1	0	0	0	0	0	3229	333	12	0	471	0	CENPC1	4	68358626	Frame_Shift_Ins	INS	-	TCGA-G2-A2EC-01A-11D-A17V-08	60144194	68358626	122795650	50	27550										
LIN54	132660	broad.mit.edu	37	chr4	83858433	83858433	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggctttcggggccgactggcCgactctgatgggattatgct	15	10	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:83858433C>G	uc003hnx.3	-	9	1929	c.1551G>C	c.(1549-1551)TCG>TCC	p.S517S	LIN54_uc003hnz.3_Silent_p.S296S|LIN54_uc003hny.3_Silent_p.S116S|LIN54_uc010ijt.2_Silent_p.S428S|LIN54_uc010iju.2_Silent_p.S116S|LIN54_uc010ijv.2_Silent_p.S296S	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	517					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				GCCGACTGGCCGACTCTGATG	0.303													0	0	0	0.006214	0	10	69										G	83858433	C	G	83858433	2	3	92	1	0	0	0	0	0	0	0	1	8809	639	23	4		4	LIN54	4	83858433	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	15499807	83858433	107295843	51	27551										
GPRIN3	285513	broad.mit.edu	37	chr4	90170794	90170794	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tttgaggttctctgtgatctCatcagggaatcttcaggcat	10	8	5	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:90170794C>T	uc003hsm.1	-	2	987	c.468G>A	c.(466-468)ATG>ATA	p.M156I		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	156										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TCTGTGATCTCATCAGGGAAT	0.517													0	0	0	0.004656	0	28	63										T	90170794	C	T	90170794	3	4	92	1	0	0	0	0	1	0	0	0	6731	826	29	1	1866	1	GPRIN3	4	90170794	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	6312361	90170794	100983482	52	27552										
LEF1	51176	broad.mit.edu	37	chr4	108999479	108999479	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ataacataaaagcattcagaGgcttcttaatgtgaggtctt	8	6	3	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:108999479G>A	uc003hyt.1	-	8	1560	c.905C>T	c.(904-906)CCT>CTT	p.P302L	LEF1_uc011cfj.1_Missense_Mutation_p.P159L|LEF1_uc011cfk.1_Missense_Mutation_p.P206L|LEF1_uc003hyu.1_Missense_Mutation_p.P274L|LEF1_uc003hyv.1_Missense_Mutation_p.P274L|LEF1_uc010imb.1_RNA|LEF1_uc010ima.1_5'UTR|LEF1_uc003hyw.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	302	HMG box.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		AGCATTCAGAGGCTTCTTAAT	0.443													0	0	0	0.01441	0	72	166										A	108999479	G	A	108999479	3	1	92	1	0	0	0	0	1	0	0	0	8714	1000	35	2	394	2	LEF1	4	108999479	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	18828685	108999479	82154797	53	27553										
LEF1	51176	broad.mit.edu	37	chr4	109084785	109084785	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	atgggtcgttattcatatttGgcatcattatgtacccggaa	9	7	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:109084785G>C	uc003hyt.1	-	3	1008	c.353C>G	c.(352-354)CCA>CGA	p.P118R	LEF1_uc011cfj.1_Missense_Mutation_p.P3R|LEF1_uc011cfk.1_Missense_Mutation_p.P50R|LEF1_uc003hyu.1_Missense_Mutation_p.P118R|LEF1_uc003hyv.1_Missense_Mutation_p.P118R|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	118	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		ATTCATATTTGGCATCATTAT	0.428													0	0	0	0.012319	0	22	70										C	109084785	G	C	109084785	3	2	92	1	0	0	0	0	1	0	0	0	8714	1348	47	4	966	4	LEF1	4	109084785	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	85306	109084785	82069491	54	27554										
ANP32C	23520	broad.mit.edu	37	chr4	165118848	165118848	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccgcagctctgaatgaatccGtctgcccatctccatctctc	6	17	4	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr4:165118848G>A	uc011cjk.1	-	1	16	c.16C>T	c.(16-18)CGG>TGG	p.R6W	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	6											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GAATGAATCCGTCTGCCCATC	0.552													0	0	0	0.006999	0	38	87										A	165118848	G	A	165118848	3	1	92	1	0	0	0	0	1	0	0	0	707	1144	40	2	691	2	ANP32C	4	165118848	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	56034063	165118848	26035428	55	27555										
SLC6A19	340024	broad.mit.edu	37	chr5	1219057	1219057	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tggccttcatcgtcttcaccGaggccatcaccaagatgccg	9	15	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:1219057G>A	uc003jbw.3	+	9	1269	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	405	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGTCTTCACCGAGGCCATCAC	0.607													0	0	0	0.008871	0	19	36										A	1219057	G	A	1219057	3	1	92	1	0	0	0	0	1	0	0	0	14682	1059	37	1	1247	1	SLC6A19	5	1219057	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		1219057	179696203	56	27556										
CTNND2	1501	broad.mit.edu	37	chr5	11117566	11117566	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgccagcacaaccaaccttgCtatcgatctcactgctcccc	5	18	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:11117566C>A	uc003jfa.1	-	13	2418	c.2273G>T	c.(2272-2274)AGC>ATC	p.S758I	CTNND2_uc010itt.2_Missense_Mutation_p.S667I|CTNND2_uc011cmy.1_Missense_Mutation_p.S421I|CTNND2_uc011cmz.1_Missense_Mutation_p.S325I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S325I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	758	ARM 6.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ACCAACCTTGCTATCGATCTC	0.512													1	0	2.12542e-12	0.00632	2.29963e-12	29	87										A	11117566	C	A	11117566	3	1	92	1	0	0	0	0	1	0	0	0	4020	797	28	4	1444	4	CTNND2	5	11117566	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	9898509	11117566	169797694	57	27557										
ADAMTS12	81792	broad.mit.edu	37	chr5	33588796	33588796	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cttcagcaggtgctggcagtCtgtgggcgggagagcctgct	17	10	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:33588796C>T	uc003jia.1	-	18	2936	c.2773G>A	c.(2773-2775)GAC>AAC	p.D925N	ADAMTS12_uc010iuq.1_Missense_Mutation_p.D840N	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	925	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGCTGGCAGTCTGTGGGCGGG	0.627										HNSCC(64;0.19)			0	0	0	0.00632	0	29	77										T	33588796	C	T	33588796	3	4	92	1	0	0	0	0	1	0	0	0	257	913	32	1	2039	1	ADAMTS12	5	33588796	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	22471230	33588796	147326464	58	27558										
RICTOR	253260	broad.mit.edu	37	chr5	38955780	38955780	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcattgagttgttcctcaatCaagtcaacatatttggagtt	7	7	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:38955780C>T	uc003jlp.2	-	26	2550	c.2526G>A	c.(2524-2526)TTG>TTA	p.L842L	RICTOR_uc003jlo.2_Silent_p.L842L|RICTOR_uc010ivf.2_Silent_p.L557L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	842					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GTTCCTCAATCAAGTCAACAT	0.358													0	0	0	0.013537	0	12	54										T	38955780	C	T	38955780	2	4	92	1	0	0	0	0	0	0	0	1	13358	825	29	1		1	RICTOR	5	38955780	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	5366984	38955780	141959480	59	27559										
PDE4D	5144	broad.mit.edu	37	chr5	58270810	58270810	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgctctggtaccattcacgaTtgtcctccaaagtgtccaaa	7	12	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:58270810T>C	uc003jsa.2	-	15	2283	c.2111A>G	c.(2110-2112)AAT>AGT	p.N704S	PDE4D_uc003jrx.2_Missense_Mutation_p.N568S|PDE4D_uc003jry.2_Missense_Mutation_p.N402S|PDE4D_uc003jrz.2_Missense_Mutation_p.N640S|PDE4D_uc003jsb.2_Missense_Mutation_p.N643S|PDE4D_uc003jrt.2_Missense_Mutation_p.N402S|PDE4D_uc003jru.2_Missense_Mutation_p.N480S|PDE4D_uc003jrv.2_Missense_Mutation_p.N574S|PDE4D_uc003jrw.2_Missense_Mutation_p.N582S|PDE4D_uc003jrs.2_Missense_Mutation_p.N413S	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	704					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CCATTCACGATTGTCCTCCAA	0.532													0	0	0	0.00308	0	8	27										C	58270810	T	C	58270810	3	2	92	1	0	0	0	0	1	0	0	0	11642	1493	52	5	322	5	PDE4D	5	58270810	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	19315030	58270810	122644450	60	27560										
FER	2241	broad.mit.edu	37	chr5	108290634	108290634	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttatcatacaatatgttgatGtacgtttccagtttagttca	6	6	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:108290634G>A	uc003kop.1	+	12	1917	c.1533_splice	c.e12+1	p.D511_splice	FER_uc011cvf.1_Intron|FER_uc011cvg.1_Splice_Site_p.D336_splice	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase						intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ATATGTTGATGTACGTTTCCA	0.343													0	0	0	0.021523	0	24	48										A	108290634	G	A	108290634	5	1	92	1	0	0	0	0	0	0	1	0	5813	1391	48	2	1572	2	FER	5	108290634	Splice_Site	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	50019824	108290634	72624626	61	27561										
PCDHB1	29930	broad.mit.edu	37	chr5	140432632	140432632	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catggattatgaggccattcAagattttcaatttgtggtaa	9	5	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:140432632A>G	uc003lik.1	+	1	1654	c.1577A>G	c.(1576-1578)CAA>CGA	p.Q526R		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	526	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGCCATTCAAGATTTTCAA	0.438													0	0	0	0.010729	0	12	39										G	140432632	A	G	140432632	3	3	92	1	0	0	0	0	1	0	0	0	11534	130	5	5	1579	5	PCDHB1	5	140432632	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	32141998	140432632	40482628	62	27562										
PCDHGA11	56105	broad.mit.edu	37	chr5	140801665	140801665	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	acatggaaagcaaggcttctGaaatattccaattggattca	8	7	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:140801665G>A	uc003lkq.1	+	1	1129	c.871G>A	c.(871-873)GAA>AAA	p.E291K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.E291K|PCDHGA11_uc003lkp.1_Missense_Mutation_p.E291K	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	291	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGGCTTCTGAAATATTCCA	0.428													0	0	0	0.010771	0	38	92										A	140801665	G	A	140801665	3	1	92	1	0	0	0	0	1	0	0	0	11552	1291	45	1	873	1	PCDHGA11	5	140801665	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	369033	140801665	40113595	63	27563										
DIAPH1	1729	broad.mit.edu	37	chr5	140960344	140960344	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcggtagaatacaaagagcaGaaagcagcttagctgcatca	11	8	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:140960344G>C	uc003llb.3	-	8	932	c.791C>G	c.(790-792)TCT>TGT	p.S264C	DIAPH1_uc003llc.3_Missense_Mutation_p.S255C	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	264	GBD/FH3.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAAGAGCAGAAAGCAGCTT	0.418													0	0	0	0.003163	0	15	55										C	140960344	G	C	140960344	3	2	92	1	0	0	0	0	1	0	0	0	4518	942	33	1	3111	1	DIAPH1	5	140960344	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	158679	140960344	39954916	64	27564										
RARS	5917	broad.mit.edu	37	chr5	167933745	167933745	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agtctgtgcacttccagacaAtatttgctgctgctcaaatg	8	10	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:167933745A>G	uc003lzx.2	+	11	1296	c.1255A>G	c.(1255-1257)ATA>GTA	p.I419V	RARS_uc011deo.1_Missense_Mutation_p.I213V	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	419					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		CTTCCAGACAATATTTGCTGC	0.398													0	0	0	0.01892	0	24	30										G	167933745	A	G	167933745	3	3	92	1	0	0	0	0	1	0	0	0	13058	101	4	5	1297	5	RARS	5	167933745	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	26973401	167933745	12981515	65	27565										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171773245	171773245	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tggggcgggatgggcggcttCggcaggttgaggcctcgagg	22	8	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:171773245C>T	uc003mbr.2	-	12	1254	c.1083G>A	c.(1081-1083)CCG>CCA	p.P361P		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	361					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGGCGGCTTCGGCAGGTTGA	0.597													0	0	0	0.019004	0	34	68										T	171773245	C	T	171773245	2	4	92	1	0	0	0	0	0	0	0	1	14257	871	31	1		1	SH3PXD2B	5	171773245	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3839500	171773245	9142015	66	27566										
C5orf45	51149	broad.mit.edu	37	chr5	179264671	179264700	+	In_Frame_Del	DEL	TGAAGAGACCTTGGCTGCTCACTGTCCACA	TGAAGAGACCTTGGCTGCTCACTGTCCACA	-													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagctggcctggggtccctcTgaagagaccttggctgctca					rs61742526	byFrequency	TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr5:179264671_179264700delTGAAGAGACCTTGGCTGCTCACTGTCCACA	uc003mla.2	-	7	767_796	c.723_752delTGTGGACAGTGAGCAGCCAAGGTCTCTTCA	c.(721-753)CATGTGGACAGTGAGCAGCCAAGGTCTCTTCAG>CAG	p.HVDSEQPRSL241del	SQSTM1_uc011dgr.1_3'UTR|SQSTM1_uc011dgs.1_3'UTR|SQSTM1_uc003mkw.3_3'UTR|SQSTM1_uc003mkx.2_3'UTR|C5orf45_uc003mky.2_Intron|C5orf45_uc011dgt.1_Intron|C5orf45_uc011dgu.1_Intron|C5orf45_uc003mlc.2_In_Frame_Del_p.HVDSEQPRSL186del|C5orf45_uc003mlb.2_In_Frame_Del_p.HVDSEQPRSL107del	NM_016175	NP_057259	Q6NTE8	CE045_HUMAN	hypothetical protein LOC51149 isoform 1	241_250											0						GGGGTCCCTCTGAAGAGACCTTGGCTGCTCACTGTCCACATGTGAACTTT	0.587																		7	28	---	---								-	179264700	TGAAGAGACCTTGGCTGCTCACTGTCCACA	-	179264671	7	5	92	1	0	1	0	1	0	0	0	0	2304	1580	55	0	283	0	C5orf45	5	179264671	In_Frame_Del	DEL	TGAAGAGACCTTGGCTGCTCACTGTCCACA	TCGA-G2-A2EC-01A-11D-A17V-08	7491426	179264671	1650589	67	27567										
NHLRC1	378884	broad.mit.edu	37	chr6	18122075	18122075	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagatgagcttgcaacctttCagttctccgaaggacccctt	8	13	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:18122075C>T	uc003ncl.1	-	1	777	c.763G>A	c.(763-765)GAA>AAA	p.E255K		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	255	NHL 4.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			TGCAACCTTTCAGTTCTCCGA	0.632													0	0	0	0.006214	0	9	23										T	18122075	C	T	18122075	3	4	92	1	0	0	0	0	1	0	0	0	10405	835	29	1	428	1	NHLRC1	6	18122075	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		18122075	152992992	68	27568										
SCAND3	114821	broad.mit.edu	37	chr6	28542657	28542657	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	actattaacacctgtgcattCtttttcacaaactacacagg	4	11	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:28542657C>G	uc003nlo.2	-	3	2443	c.1825G>C	c.(1825-1827)GAA>CAA	p.E609Q		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	609					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCTGTGCATTCTTTTTCACAA	0.413													0	0	0	0.006214	0	10	18										G	28542657	C	G	28542657	3	3	92	1	0	0	0	0	1	0	0	0	13876	922	32	1	2160	1	SCAND3	6	28542657	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	10420582	28542657	142572410	69	27569										
TNXB	7148	broad.mit.edu	37	chr6	32014154	32014155	+	Nonsense_Mutation	DNP	GG	GG	TT													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gggccctgggctaccgtccaGgacaggcgcagagagctgga							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:32014154_32014155GG>TT	uc003nzl.2	-	31	10599_10600	c.10397_10398CC>AA	c.(10396-10398)TCC>TAA	p.S3466*	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_Translation_Start_Site	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3513	Fibronectin type-III 27.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTACCGTCCAGGACAGGCGCAG	0.663													0	0	0	0.004672	0	16	23										TT	32014155	GG	TT	32014154	4	4	92	1	0	0	0	0	0	1	0	0	16343	987	35	4	4371	4	TNXB	6	32014154	Nonsense_Mutation	DNP	GG	TCGA-G2-A2EC-01A-11D-A17V-08	3471497	32014154	139100913	70	27570										
FKBP5	2289	broad.mit.edu	37	chr6	35543683	35543683	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tttttcattagtgaccccttCtgaagtcttcttgcccattg	6	11	4	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:35543683C>A	uc011dte.1	-	11	1506	c.1303G>T	c.(1303-1305)GAA>TAA	p.E435*	FKBP5_uc003okx.2_Nonsense_Mutation_p.E435*|FKBP5_uc011dtf.1_Nonsense_Mutation_p.E256*|FKBP5_uc003oky.2_Nonsense_Mutation_p.E435*	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	435					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GTGACCCCTTCTGAAGTCTTC	0.448													1	0	1.86633e-21	0.01441	2.036e-21	48	160										A	35543683	C	A	35543683	4	1	92	1	0	0	0	0	0	1	0	0	5911	922	32	3	74	3	FKBP5	6	35543683	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3529529	35543683	135571384	71	27571										
LRFN2	57497	broad.mit.edu	37	chr6	40360393	40360393	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagaccttgtagcgcaccatGaggatgacgatgaagaccag	12	10	0	5			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:40360393G>A	uc003oph.1	-	3	2124	c.1659C>T	c.(1657-1659)CTC>CTT	p.L553L		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	553	Helical; (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCGCACCATGAGGATGACGA	0.632													0	0	0	0.008291	0	11	22										A	40360393	G	A	40360393	2	1	92	1	0	0	0	0	0	0	0	1	8938	1277	45	1		1	LRFN2	6	40360393	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	4816710	40360393	130754674	72	27572										
TRERF1	55809	broad.mit.edu	37	chr6	42224510	42224510	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagagagtgcaaagcaaattCagaattggtccctccacctg	9	11	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:42224510C>T	uc003osd.2	-	12	3099	c.2536G>A	c.(2536-2538)GAA>AAA	p.E846K	TRERF1_uc011duq.1_Missense_Mutation_p.E763K|TRERF1_uc003osb.2_Missense_Mutation_p.E602K|TRERF1_uc003osc.2_Missense_Mutation_p.E602K|TRERF1_uc003ose.2_Missense_Mutation_p.E866K	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	846	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AAAGCAAATTCAGAATTGGTC	0.438													0	0	0	0.00499	0	15	43										T	42224510	C	T	42224510	3	4	92	1	0	0	0	0	1	0	0	0	16472	835	29	1	1094	1	TRERF1	6	42224510	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1864117	42224510	128890557	73	27573										
PKHD1	5314	broad.mit.edu	37	chr6	51768474	51768474	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tggagagtccctcggcaccaGaaacctggatgatcacgttg	12	11	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:51768474G>A	uc003pah.1	-	43	7193	c.6917C>T	c.(6916-6918)TCT>TTT	p.S2306F	PKHD1_uc010jzn.1_Missense_Mutation_p.S289F|PKHD1_uc003pai.2_Missense_Mutation_p.S2306F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2306	PbH1 3.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTCGGCACCAGAAACCTGGAT	0.413													0	0	0	0.016522	0	23	67										A	51768474	G	A	51768474	3	1	92	1	0	0	0	0	1	0	0	0	11971	942	33	1	5446	1	PKHD1	6	51768474	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	9543964	51768474	119346593	74	27574										
BACH2	60468	broad.mit.edu	37	chr6	90642373	90642373	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggcacgttttcccccactgcGcattgggaggccgcaatgtt	12	13	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:90642373G>A	uc011eab.1	-	9	3089	c.2280C>T	c.(2278-2280)TGC>TGT	p.C760C	BACH2_uc003pnw.2_Silent_p.C760C	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	760						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CCCCCACTGCGCATTGGGAGG	0.637													0	0	0	0.013537	0	11	34										A	90642373	G	A	90642373	2	1	92	1	0	0	0	0	0	0	0	1	1284	1079	38	2		2	BACH2	6	90642373	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	38873899	90642373	80472694	75	27575										
RBM16	22828	broad.mit.edu	37	chr6	155153375	155153375	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gacttgtaggagtacagccaCcaaatgttccaaatactcct	7	11	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:155153375C>G	uc003qqa.2	+	21	2894	c.2662C>G	c.(2662-2664)CCA>GCA	p.P888A	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.P954A|RBM16_uc011efk.1_Missense_Mutation_p.P933A|RBM16_uc003qpz.2_Missense_Mutation_p.P888A|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	888	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		AGTACAGCCACCAAATGTTCC	0.458													0	0	0	0.010818	0	33	42										G	155153375	C	G	155153375	3	3	92	1	0	0	0	0	1	0	0	0	13118	507	18	4	2740	4	RBM16	6	155153375	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	64511002	155153375	15961692	76	27576										
RBM16	22828	broad.mit.edu	37	chr6	155153393	155153393	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caccaaatgttccaaatactCctggacttctgggaacacag	7	12	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr6:155153393C>G	uc003qqa.2	+	21	2912	c.2680C>G	c.(2680-2682)CCT>GCT	p.P894A	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.P960A|RBM16_uc011efk.1_Missense_Mutation_p.P939A|RBM16_uc003qpz.2_Missense_Mutation_p.P894A|RBM16_uc010kji.2_Intron	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	894	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TCCAAATACTCCTGGACTTCT	0.453													0	0	0	0.013726	0	34	47										G	155153393	C	G	155153393	3	3	92	1	0	0	0	0	1	0	0	0	13118	855	30	1	2758	1	RBM16	6	155153393	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	18	155153393	15961674	77	27577										
MIOS	54468	broad.mit.edu	37	chr7	7612191	7612191	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	actcagaactaagtctttatCatgtggaatctactgtgaat	7	7	4	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:7612191C>G	uc003srf.2	+	4	393	c.85C>G	c.(85-87)CAT>GAT	p.H29D	MIOS_uc010ktp.1_Missense_Mutation_p.H29D	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	29											0						AAGTCTTTATCATGTGGAATC	0.383													0	0	0	0.004482	0	9	28										G	7612191	C	G	7612191	3	3	92	1	0	0	0	0	1	0	0	0	9589	826	29	1	87	1	MIOS	7	7612191	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		7612191	151526472	78	27578										
GLI3	2737	broad.mit.edu	37	chr7	42005908	42005908	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cggtactgctgggcgggcgtGaggctgagcaggctgggcag	21	9	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:42005908G>A	uc011kbh.1	-	15	2854	c.2763C>T	c.(2761-2763)CTC>CTT	p.L921L	GLI3_uc011kbg.1_Silent_p.L862L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	921					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GGGCGGGCGTGAGGCTGAGCA	0.701									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.006214	0	9	23										A	42005908	G	A	42005908	2	1	92	1	0	0	0	0	0	0	0	1	6439	1277	45	1		1	GLI3	7	42005908	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	34393717	42005908	117132755	79	27579										
ASL	435	broad.mit.edu	37	chr7	65553815	65553815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cgagttcctgttctgggcttCgctgtgcatgacccatctca	10	13	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:65553815C>T	uc003tuo.2	+	11	851	c.740C>T	c.(739-741)TCG>TTG	p.S247L	ASL_uc003tup.2_Missense_Mutation_p.S247L|ASL_uc003tur.2_Missense_Mutation_p.S221L|ASL_uc003tuq.2_Missense_Mutation_p.S247L	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	247					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	TTCTGGGCTTCGCTGTGCATG	0.587													0	0	0	0.004482	0	8	34										T	65553815	C	T	65553815	3	4	92	1	0	0	0	0	1	0	0	0	1044	893	31	1	778	1	ASL	7	65553815	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	23547907	65553815	93584848	80	27580										
FZD9	8326	broad.mit.edu	37	chr7	72849364	72849364	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcacctggttcctggctgccGggaagaaatggggccacgag	15	11	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:72849364G>A	uc003tyb.2	+	1	1256	c.1027G>A	c.(1027-1029)GGG>AGG	p.G343R		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	343	Cytoplasmic (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CCTGGCTGCCGGGAAGAAATG	0.637													0	0	0	0.006214	0	10	47										A	72849364	G	A	72849364	3	1	92	1	0	0	0	0	1	0	0	0	6137	1116	39	2	1029	2	FZD9	7	72849364	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	7295549	72849364	86289299	81	27581										
CLIP2	7461	broad.mit.edu	37	chr7	73771712	73771712	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	acattgagcagctgctggctGaacgagacctggaacgggct	14	10	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:73771712G>A	uc003uam.2	+	6	1447	c.1120G>A	c.(1120-1122)GAA>AAA	p.E374K	CLIP2_uc003uan.2_Missense_Mutation_p.E374K	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	374	Potential.					microtubule associated complex				skin(3)	3						GCTGCTGGCTGAACGAGACCT	0.612													0	0	0	0.001984	0	6	9										A	73771712	G	A	73771712	3	1	92	1	0	0	0	0	1	0	0	0	3533	1291	45	1	1138	1	CLIP2	7	73771712	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	922348	73771712	85366951	82	27582										
CLIP2	7461	broad.mit.edu	37	chr7	73811473	73811473	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccagggccggagagggacctGagccgtgaggtacacaaggc	17	11	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:73811473G>C	uc003uam.2	+	14	3117	c.2790G>C	c.(2788-2790)CTG>CTC	p.L930L	CLIP2_uc003uan.2_Silent_p.L895L	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	930	Potential.					microtubule associated complex				skin(3)	3						AGAGGGACCTGAGCCGTGAGG	0.627													0	0	0	0.010729	0	11	28										C	73811473	G	C	73811473	2	2	92	1	0	0	0	0	0	0	0	1	3533	1277	45	1		1	CLIP2	7	73811473	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	39761	73811473	85327190	83	27583										
ZC3HAV1L	92092	broad.mit.edu	37	chr7	138711457	138711457	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccccctttaaggtttacctgGgcagggcttcttggccgact	11	13	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:138711457G>A	uc003vum.1	-	4	895	c.883C>T	c.(883-885)CCA>TCA	p.P295S		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	295											0						GGTTTACCTGGGCAGGGCTTC	0.502													0	0	0	0.014758	0	5	93										A	138711457	G	A	138711457	3	1	92	1	0	0	0	0	1	0	0	0	17573	1232	43	2	27	2	ZC3HAV1L	7	138711457	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	64899984	138711457	20427206	84	27584										
CUL1	8454	broad.mit.edu	37	chr7	148487405	148487405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gctgtccttttatctagttgGaacgtagttatcagcgattc	9	8	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr7:148487405G>A	uc010lpg.2	+	16	2204	c.1678G>A	c.(1678-1680)GAA>AAA	p.E560K	CUL1_uc003wey.2_Missense_Mutation_p.E560K|CUL1_uc003wez.2_Missense_Mutation_p.E450K|CUL1_uc003wfa.2_Missense_Mutation_p.E221K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	560					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TATCTAGTTGGAACGTAGTTA	0.428													0	0	0	0.007413	0	14	35										A	148487405	G	A	148487405	3	1	92	1	0	0	0	0	1	0	0	0	4054	1175	41	1	1736	1	CUL1	7	148487405	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	9775948	148487405	10651258	85	27585										
CSMD1	64478	broad.mit.edu	37	chr8	3000065	3000065	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gagggtttcatgcgttgtgcTcagcagggccgcggggagat	18	8	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:3000065T>C	uc011kwk.1	-	41	6556	c.6166A>G	c.(6166-6168)AGC>GGC	p.S2056G	CSMD1_uc011kwj.1_Missense_Mutation_p.S1448G|CSMD1_uc010lrg.2_Missense_Mutation_p.S124G	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2056	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCGTTGTGCTCAGCAGGGCC	0.478													0	0	0	0.001168	0	6	36										C	3000065	T	C	3000065	3	2	92	1	0	0	0	0	1	0	0	0	3944	1551	54	5	4651	5	CSMD1	8	3000065	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08		3000065	143363957	86	27586										
SCARA3	51435	broad.mit.edu	37	chr8	27507313	27507313	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccgaccttcccatgcacccaGaagggtaaggactctggggc	12	14	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:27507313G>C	uc003xga.1	+	2	243	c.102G>C	c.(100-102)CAG>CAC	p.Q34H	SCARA3_uc003xgb.1_Missense_Mutation_p.Q34H	NM_016240	NP_057324	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3 isoform 1	34	Cytoplasmic (Potential).				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			skin(2)|ovary(1)|breast(1)	4		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		CATGCACCCAGAAGGGTAAGG	0.592													0	0	0	0.00308	0	8	17										C	27507313	G	C	27507313	3	2	92	1	0	0	0	0	1	0	0	0	13879	933	33	1	108	1	SCARA3	8	27507313	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	24507248	27507313	118856709	87	27587										
PURG	29942	broad.mit.edu	37	chr8	30890034	30890034	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcctctccctatccagacttCggctatctttaggaagcggc	9	14	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:30890034C>T	uc003xin.2	-	1	284	c.265G>A	c.(265-267)GAA>AAA	p.E89K	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.E89K	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	89	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		ATCCAGACTTCGGCTATCTTT	0.542													0	0	0	0.003163	0	16	27										T	30890034	C	T	30890034	3	4	92	1	0	0	0	0	1	0	0	0	12829	893	31	1	891	1	PURG	8	30890034	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3382721	30890034	115473988	88	27588										
GOT1L1	137362	broad.mit.edu	37	chr8	37791899	37791899	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggacagcctcattgatgcccTcagtgatgtaatttatgttg	10	8	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:37791899T>A	uc011lbj.1	-	9	1278	c.1178A>T	c.(1177-1179)GAG>GTG	p.E393V		NM_152413	NP_689626	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	393					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			ovary(1)	1	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			ATTGATGCCCTCAGTGATGTA	0.408													0	0	0	0.009718	0	42	86										A	37791899	T	A	37791899	3	1	92	1	0	0	0	0	1	0	0	0	6580	1551	54	5	91	5	GOT1L1	8	37791899	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	6901865	37791899	108572123	89	27589										
POTEA	340441	broad.mit.edu	37	chr8	43197470	43197470	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caactcaaaatggattttaaCggtaggaccattgcataagt	8	7	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:43197470C>T	uc003xpz.1	+	11	1402	c.1359C>T	c.(1357-1359)AAC>AAT	p.N453N	POTEA_uc003xqa.1_Silent_p.N407N	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	453										ovary(1)	1						TGGATTTTAACGGTAGGACCA	0.373													0	0	0	0.004656	0	21	35										T	43197470	C	T	43197470	2	4	92	1	0	0	0	0	0	0	0	1	12261	550	19	2		2	POTEA	8	43197470	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	5405571	43197470	103166552	90	27590										
NPBWR1	2831	broad.mit.edu	37	chr8	53853373	53853373	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agctacgccaacagctgcctCaaccccttcctctacgcctt	5	19	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:53853373C>T	uc011ldu.1	+	1	906	c.906C>T	c.(904-906)CTC>CTT	p.L302L		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	302	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				ACAGCTGCCTCAACCCCTTCC	0.652													0	0	0	0.016723	0	11	24										T	53853373	C	T	53853373	2	4	92	1	0	0	0	0	0	0	0	1	10568	813	29	1		1	NPBWR1	8	53853373	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	10655903	53853373	92510649	91	27591										
ANKRD46	157567	broad.mit.edu	37	chr8	101540176	101540176	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttccagcaatcggatgacatCtttatttactcctctgcgct	6	12	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:101540176C>G	uc003yjm.2	-	4	571	c.367G>C	c.(367-369)GAT>CAT	p.D123H	ANKRD46_uc003yjn.1_Missense_Mutation_p.D123H|ANKRD46_uc003yjo.1_Missense_Mutation_p.D123H|ANKRD46_uc003yjp.1_Missense_Mutation_p.D123H	NM_198401	NP_940683	Q86W74	ANR46_HUMAN	ankyrin repeat domain 46	123	ANK 4.					integral to membrane					0	all_cancers(14;5.07e-05)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000353)|all_lung(17;0.000998)		Epithelial(11;2.61e-11)|all cancers(13;5.03e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.49e-06)|STAD - Stomach adenocarcinoma(118;0.0957)			CGGATGACATCTTTATTTACT	0.383													0	0	0	0.01892	0	22	67										G	101540176	C	G	101540176	3	3	92	1	0	0	0	0	1	0	0	0	674	913	32	1	327	1	ANKRD46	8	101540176	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	47686803	101540176	44823846	92	27592										
CSMD3	114788	broad.mit.edu	37	chr8	113358422	113358422	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gatcacaccactgaagtctgAcatagcaccaccacactgag	7	14	2	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr8:113358422A>G	uc003ynu.2	-	41	6505	c.6346T>C	c.(6346-6348)TCA>CCA	p.S2116P	CSMD3_uc003yns.2_Missense_Mutation_p.S1318P|CSMD3_uc003ynt.2_Missense_Mutation_p.S2076P|CSMD3_uc011lhx.1_Missense_Mutation_p.S2012P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2116	Extracellular (Potential).|CUB 12.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGAAGTCTGACATAGCACCA	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004007	0	15	43										G	113358422	A	G	113358422	3	3	92	1	0	0	0	0	1	0	0	0	3946	275	10	5	4901	5	CSMD3	8	113358422	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	11818246	113358422	33005600	93	27593										
C9orf23	138716	broad.mit.edu	37	chr9	34611268	34611268	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaggcgctgggagctctacaGagccagctttccggtagtgc	14	11	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:34611268G>A	uc003zuu.2	-	2	307	c.26C>T	c.(25-27)TCT>TTT	p.S9F	C9orf23_uc003zuv.2_Missense_Mutation_p.S9F	NM_148179	NP_680545	Q8N5L8	CI023_HUMAN	hypothetical protein LOC138716	9							nucleic acid binding				0	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0385)		GAGCTCTACAGAGCCAGCTTT	0.577													0	0	0	0.001168	0	5	14										A	34611268	G	A	34611268	3	1	92	1	0	0	0	0	1	0	0	0	2474	942	33	1	469	1	C9orf23	9	34611268	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		34611268	106602163	94	27594										
OR1N2	138882	broad.mit.edu	37	chr9	125316096	125316096	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catgtaaacgagctgatgatCatcaccatgggcttgctgtt	10	9	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:125316096C>A	uc011lyx.1	+	1	648	c.648C>A	c.(646-648)ATC>ATA	p.I216I		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						AGCTGATGATCATCACCATGG	0.502													1	0	4.67007e-22	0.00874	5.11576e-22	32	63										A	125316096	C	A	125316096	2	1	92	1	0	0	0	0	0	0	0	1	10970	816	29	3		3	OR1N2	9	125316096	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	90704828	125316096	15897335	95	27595										
RABEPK	10244	broad.mit.edu	37	chr9	127996161	127996161	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gccacagtggtgactcacatGaggaaagccagactgctaca	11	11	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:127996161G>A	uc004bpi.2	+	9	1194	c.1021G>A	c.(1021-1023)GAG>AAG	p.E341K	RABEPK_uc004bpj.2_Missense_Mutation_p.E290K|RABEPK_uc004bpk.2_Missense_Mutation_p.E341K|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.E341K	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	341					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TGACTCACATGAGGAAAGCCA	0.438													0	0	0	0.009535	0	32	65										A	127996161	G	A	127996161	3	1	92	1	0	0	0	0	1	0	0	0	12963	1291	45	1	1047	1	RABEPK	9	127996161	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	2680065	127996161	13217270	96	27596										
RABEPK	10244	broad.mit.edu	37	chr9	127996208	127996208	+	Missense_Mutation	SNP	G	G	A													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgtttggtgtttggtgggatGaatacagaaggggaaatcta							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:127996208G>A	uc004bpi.2	+	9	1241	c.1068G>A	c.(1066-1068)ATG>ATA	p.M356I	RABEPK_uc004bpj.2_Missense_Mutation_p.M305I|RABEPK_uc004bpk.2_Missense_Mutation_p.M356I|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.M356I	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	356					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						TTGGTGGGATGAATACAGAAG	0.408													0	0	0	0.007835	0	37	85										A	127996208	G	A	127996208	3	1	92	1	0	0	0	0	1	0	0	0	12963	1290	45	1	1094	1	RABEPK	9	127996208	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	47	127996208	13217223	97	27597	136	2								
RABEPK	10244	broad.mit.edu	37	chr9	127996215	127996215	+	Missense_Mutation	SNP	G	G	A													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgtttggtgggatgaatacaGaaggggaaatctatgacgat							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:127996215G>A	uc004bpi.2	+	9	1248	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	RABEPK_uc004bpj.2_Missense_Mutation_p.E308K|RABEPK_uc004bpk.2_Missense_Mutation_p.E359K|RABEPK_uc004bpl.1_3'UTR|RABEPK_uc004bpm.2_Missense_Mutation_p.E359K	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	359					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						GATGAATACAGAAGGGGAAAT	0.398													0	0	0	0.007835	0	36	86										A	127996215	G	A	127996215	3	1	92	1	0	0	0	0	1	0	0	0	12963	943	33	1	1101	1	RABEPK	9	127996215	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	7	127996215	13217216	98	27598	136	2								
SPTAN1	6709	broad.mit.edu	37	chr9	131367428	131367429	+	Frame_Shift_Del	DEL	GA	GA	-													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aacgcaagcatgagggcttcGagagggaccttgcggctctc							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:131367428_131367429delGA	uc004bvl.3	+	30	3948_3949	c.3835_3836delGA	c.(3835-3837)GAGfs	p.E1279fs	SPTAN1_uc011mbh.1_Frame_Shift_Del_p.E1291fs|SPTAN1_uc004bvm.3_Frame_Shift_Del_p.E1279fs|SPTAN1_uc004bvn.3_Frame_Shift_Del_p.E1259fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1279	Spectrin 14.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAGGGCTTCGAGAGGGACCTT	0.5																		11	22	---	---								-	131367429	GA	-	131367428	7	5	92	1	0	1	0	1	0	0	0	0	15116	1059	37	0	3949	0	SPTAN1	9	131367428	Frame_Shift_Del	DEL	GA	TCGA-G2-A2EC-01A-11D-A17V-08	3371213	131367428	9846003	99	27599										
CRAT	1384	broad.mit.edu	37	chr9	131870096	131870096	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aggatgccctcactcacccaGttctccgtcttcctggcccg	8	18	4	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:131870096G>C	uc004bxh.2	-	2	570	c.288C>G	c.(286-288)AAC>AAG	p.N96K	CRAT_uc004bxg.2_Missense_Mutation_p.N75K|CRAT_uc004bxk.3_Missense_Mutation_p.N75K|CRAT_uc004bxj.2_Missense_Mutation_p.N97K	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	96					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	CACTCACCCAGTTCTCCGTCT	0.637													0	0	0	0.008291	0	9	13										C	131870096	G	C	131870096	3	2	92	1	0	0	0	0	1	0	0	0	3847	1020	36	4	1644	4	CRAT	9	131870096	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	502668	131870096	9343335	100	27600										
ABL1	25	broad.mit.edu	37	chr9	133589745	133589745	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaagtacttggggaccaaagAaggccaagcttgcctgccct	11	11	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr9:133589745A>G	uc004bzv.2	+	1	478	c.39A>G	c.(37-39)AGA>AGG	p.R13R		NM_007313	NP_009297	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	Error:Variant_position_missing_in_P00519_after_alignment					actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GGGACCAAAGAAGGCCAAGCT	0.498			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.010504	0	21	21										G	133589745	A	G	133589745	2	3	92	1	0	0	0	0	0	0	0	1	92	243	9	5		5	ABL1	9	133589745	Silent	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	1719649	133589745	7623686	101	27601										
TUBAL3	79861	broad.mit.edu	37	chr10	5437320	5437320	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtcctctccagcacaaggtcGatgacctccgaccccacaga	8	17	1	2	rs144348755		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:5437320G>A	uc001ihy.2	-	3	406	c.366C>T	c.(364-366)ATC>ATT	p.I122I	TUBAL3_uc001ihz.2_Silent_p.I82I	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	122					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						GCACAAGGTCGATGACCTCCG	0.622													0	0	0	0.009718	0	42	67										A	5437320	G	A	5437320	2	1	92	1	0	0	0	0	0	0	0	1	16748	1048	37	1		1	TUBAL3	10	5437320	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		5437320	130097427	102	27602										
NRP1	8829	broad.mit.edu	37	chr10	33469270	33469270	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gttcttgtcaccttctccttCaccttcgtatcctggcgtgc	7	15	4	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:33469270C>T	uc001iwx.3	-	17	3029	c.2506G>A	c.(2506-2508)GAA>AAA	p.E836K	NRP1_uc001iwv.3_Missense_Mutation_p.E819K|NRP1_uc009xlz.2_Missense_Mutation_p.E830K|NRP1_uc001iww.3_Missense_Mutation_p.E648K|NRP1_uc001iwy.3_Missense_Mutation_p.E829K	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	836	Extracellular (Potential).				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	CCTTCTCCTTCACCTTCGTAT	0.488													0	0	0	0.01441	0	50	73										T	33469270	C	T	33469270	3	4	92	1	0	0	0	0	1	0	0	0	10660	835	29	1	269	1	NRP1	10	33469270	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	28031950	33469270	102065477	103	27603										
RBP3	5949	broad.mit.edu	37	chr10	48388414	48388414	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctggggcaaggtccacacctCcgtgacttttgaggtggccc	13	13	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:48388414C>T	uc001jez.2	-	1	2578	c.2464G>A	c.(2464-2466)GAG>AAG	p.E822K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	822	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GTCCACACCTCCGTGACTTTT	0.617													0	0	0	0.014758	0	4	33										T	48388414	C	T	48388414	3	4	92	1	0	0	0	0	1	0	0	0	13157	864	30	1	1295	1	RBP3	10	48388414	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	14919144	48388414	87146333	104	27604										
ADAMTS14	140766	broad.mit.edu	37	chr10	72496495	72496495	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catcctgacaacccgtacttCtgcaagaccaagaaggggcc	9	14	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:72496495C>T	uc001jrh.2	+	10	1545	c.1545C>T	c.(1543-1545)TTC>TTT	p.F515F	ADAMTS14_uc001jrg.2_Silent_p.F518F|ADAMTS14_uc001jri.1_Silent_p.F38F	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	515	Disintegrin.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACCCGTACTTCTGCAAGACCA	0.622													0	0	0	0.016522	0	21	26										T	72496495	C	T	72496495	2	4	92	1	0	0	0	0	0	0	0	1	259	912	32	1		1	ADAMTS14	10	72496495	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	24108081	72496495	63038252	105	27605										
ANKRD1	27063	broad.mit.edu	37	chr10	92672725	92672725	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agcaccagatccatcggcgtCttcccagcctaatcaaatga	7	14	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:92672725C>A	uc001khe.1	-	9	1106	c.858G>T	c.(856-858)AAG>AAT	p.K286N		NM_014391	NP_055206	Q15327	ANKR1_HUMAN	cardiac ankyrin repeat protein	286	ANK 5.				cellular lipid metabolic process|defense response|signal transduction		DNA binding				0		Colorectal(252;0.0475)				CCATCGGCGTCTTCCCAGCCT	0.448													1	0	7.11191e-15	0.013726	7.72652e-15	34	49										A	92672725	C	A	92672725	3	1	92	1	0	0	0	0	1	0	0	0	637	912	32	3	105	3	ANKRD1	10	92672725	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	20176230	92672725	42862022	106	27606										
NFKB2	4791	broad.mit.edu	37	chr10	104156527	104156527	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtgaaggcccctcccatggaGgactgcccggtgcctccagt	13	15	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr10:104156527G>A	uc001kvb.2	+	5	455	c.190G>A	c.(190-192)GGA>AGA	p.G64R	NFKB2_uc001kva.2_Missense_Mutation_p.G64R|NFKB2_uc010qqk.1_Missense_Mutation_p.G64R|NFKB2_uc001kvd.2_Missense_Mutation_p.G64R|NFKB2_uc009xxc.2_Missense_Mutation_p.G64R	NM_001077494	NP_001070962	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene	64	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(3)	3		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		CTCCCATGGAGGACTGCCCGG	0.592			T	IGH@	B-NHL								0	0	0	0.001984	0	6	76										A	104156527	G	A	104156527	3	1	92	1	0	0	0	0	1	0	0	0	10376	1001	35	2	204	2	NFKB2	10	104156527	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	11483802	104156527	31378220	107	27607										
NAP1L4	4676	broad.mit.edu	37	chr11	2975819	2975819	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agcccgcgggactatccgctCacggaaaaagtgtccaattt	10	12	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:2975819C>T	uc001lxc.2	-	12	1114	c.973G>A	c.(973-975)GAG>AAG	p.E325K	NAP1L4_uc001lxb.2_5'Flank|NAP1L4_uc009ydt.2_RNA|NAP1L4_uc010qxm.1_Missense_Mutation_p.E325K|NAP1L4_uc010qxn.1_Missense_Mutation_p.E325K	NM_005969	NP_005960	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	325					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			ovary(1)	1		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		ACTATCCGCTCACGGAAAAAG	0.483													0	0	0	0.010729	0	11	30										T	2975819	C	T	2975819	3	4	92	1	0	0	0	0	1	0	0	0	10159	835	29	1	170	1	NAP1L4	11	2975819	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		2975819	132030697	108	27608										
C11orf40	143501	broad.mit.edu	37	chr11	4593489	4593489	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gggctgagatccaggaaataGagattccactggaaacacgt	12	8	0	2	rs141444146		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:4593489G>C	uc010qyg.1	-	3	344	c.344C>G	c.(343-345)TCT>TGT	p.S115C		NM_144663	NP_653264	Q8WZ69	CK040_HUMAN	hypothetical protein LOC143501	115										ovary(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCAGGAAATAGAGATTCCACT	0.458													0	0	0	0.013537	0	11	27										C	4593489	G	C	4593489	3	2	92	1	0	0	0	0	1	0	0	0	1639	942	33	1	316	1	C11orf40	11	4593489	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1617670	4593489	130413027	109	27609										
FOLH1	2346	broad.mit.edu	37	chr11	49175904	49175904	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaagggagcactatggaattGgctagctcaaacaccatccc	9	11	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:49175904G>T	uc001ngy.2	-	16	2025	c.1764C>A	c.(1762-1764)GCC>GCA	p.A588A	FOLH1_uc001ngx.2_Silent_p.A20A|FOLH1_uc001ngz.2_Silent_p.A588A|FOLH1_uc009yly.2_Silent_p.A573A|FOLH1_uc009ylz.2_Silent_p.A573A|FOLH1_uc009yma.2_Silent_p.A280A	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	588	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CTATGGAATTGGCTAGCTCAA	0.383													1	0	2.27111e-07	0.013537	2.40792e-07	7	42										T	49175904	G	T	49175904	2	4	92	1	0	0	0	0	0	0	0	1	5979	1335	47	4		4	FOLH1	11	49175904	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	44582415	49175904	85830612	110	27610										
OR5D18	219438	broad.mit.edu	37	chr11	55587651	55587651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aatcacttcttctgtgagttCtcctcactactctccctttc	3	15	6	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:55587651C>G	uc010rin.1	+	1	546	c.546C>G	c.(544-546)TTC>TTG	p.F182L		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCTGTGAGTTCTCCTCACTAC	0.428													0	0	0	0.008361	0	29	76										G	55587651	C	G	55587651	3	3	92	1	0	0	0	0	1	0	0	0	11157	912	32	1	548	1	OR5D18	11	55587651	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	6411747	55587651	79418865	111	27611										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57080172	57080172	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cctacacaagtcttgagcctCtgtcctggcttgggtggtct	11	12	3	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:57080172C>G	uc001njr.2	-	4	2302	c.1990G>C	c.(1990-1992)GAG>CAG	p.E664Q	TNKS1BP1_uc001njs.2_Missense_Mutation_p.E664Q|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.E115Q	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	664	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				TCTTGAGCCTCTGTCCTGGCT	0.642													0	0	0	0.016723	0	13	29										G	57080172	C	G	57080172	3	3	92	1	0	0	0	0	1	0	0	0	16317	922	32	1	3227	1	TNKS1BP1	11	57080172	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1492521	57080172	77926344	112	27612										
UBE2L6	9246	broad.mit.edu	37	chr11	57327878	57327878	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caggttccgcaggtatggggGaggcttcttctgaagatcct	14	9	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:57327878G>T	uc001nkn.1	-	2	151	c.55C>A	c.(55-57)CCC>ACC	p.P19T	UBE2L6_uc001nko.1_5'UTR	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	19					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						AGGTATGGGGGAGGCTTCTTC	0.592													1	0	1.3612e-06	0.003163	1.42602e-06	16	64										T	57327878	G	T	57327878	3	4	92	1	0	0	0	0	1	0	0	0	16861	1174	41	3	418	3	UBE2L6	11	57327878	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	247706	57327878	77678638	113	27613										
RAB3IL1	5866	broad.mit.edu	37	chr11	61675683	61675683	+	Frame_Shift_Del	DEL	G	G	-													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aggtctccaccagggctcctGgggactccctgtggccttgg							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:61675683delG	uc001nso.2	-	2	265	c.107delC	c.(106-108)CCAfs	p.P36fs	RAB3IL1_uc001nsp.2_Frame_Shift_Del_p.P83fs	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	36							protein binding			skin(2)|central_nervous_system(1)	3						CAGGGCTCCTGGGGACTCCCT	0.721																		2	4	---	---								-	61675683	G	-	61675683	7	5	92	1	0	1	0	1	0	0	0	0	12937	1348	47	0	1077	0	RAB3IL1	11	61675683	Frame_Shift_Del	DEL	G	TCGA-G2-A2EC-01A-11D-A17V-08	4347805	61675683	73330833	114	27614										
STIP1	10963	broad.mit.edu	37	chr11	63970354	63970354	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttgcttcattctaggactgtGaggaatgtatccagctggag	12	7	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:63970354G>A	uc001nyk.1	+	11	1399	c.1252G>A	c.(1252-1254)GAG>AAG	p.E418K	STIP1_uc010rnb.1_Missense_Mutation_p.E394K	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	418	TPR 8.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						CTAGGACTGTGAGGAATGTAT	0.483													0	0	0	0.01892	0	23	68										A	63970354	G	A	63970354	3	1	92	1	0	0	0	0	1	0	0	0	15284	1291	45	1	1294	1	STIP1	11	63970354	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	2294671	63970354	71036162	115	27615										
PLCB3	5331	broad.mit.edu	37	chr11	64022383	64022383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tactcaggaccccaagatccGggaagttctgggctttgggg	14	10	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:64022383G>A	uc001nzb.2	+	4	260	c.260G>A	c.(259-261)CGG>CAG	p.R87Q	PLCB3_uc009ypg.1_Missense_Mutation_p.R87Q|PLCB3_uc009yph.1_Intron|PLCB3_uc009ypi.2_Missense_Mutation_p.R87Q	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	87					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCCAAGATCCGGGAAGTTCTG	0.607													0	0	0	0.004672	0	3	29										A	64022383	G	A	64022383	3	1	92	1	0	0	0	0	1	0	0	0	12029	1116	39	2	274	2	PLCB3	11	64022383	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	52029	64022383	70984133	116	27616										
AIP	9049	broad.mit.edu	37	chr11	67257650	67257650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aggctgctgccaagtactacGatgccattgcctgcctcaag	10	13	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:67257650G>A	uc001olv.2	+	4	735	c.610G>A	c.(610-612)GAT>AAT	p.D204N		NM_003977	NP_003968	O00170	AIP_HUMAN	aryl hydrocarbon receptor interacting protein	204	TPR 1.				protein maturation by protein folding|protein targeting to mitochondrion	nucleus	signal transducer activity|transcription coactivator activity|transcription factor binding|unfolded protein binding				0						CAAGTACTACGATGCCATTGC	0.607									Familial_Isolated_Pituitary_Adenoma_				0	0	0	0.013537	0	10	23										A	67257650	G	A	67257650	3	1	92	1	0	0	0	0	1	0	0	0	435	1058	37	1	624	1	AIP	11	67257650	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	3235267	67257650	67748866	117	27617										
SHANK2	22941	broad.mit.edu	37	chr11	70319408	70319408	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gaccacagggcttggggcacGtcttgttcctgaggtcctgc	14	12	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:70319408G>A	uc001oqc.2	-	22	5194	c.5116C>T	c.(5116-5118)CGT>TGT	p.R1706C	SHANK2_uc010rqn.1_Missense_Mutation_p.R1118C|SHANK2_uc001opz.2_Missense_Mutation_p.R1111C|uc009ysn.1_Intron|SHANK2_uc001opy.2_Missense_Mutation_p.R42C	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1327					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CTTGGGGCACGTCTTGTTCCT	0.642													0	0	0	0.014758	0	5	46										A	70319408	G	A	70319408	3	1	92	1	0	0	0	0	1	0	0	0	14265	1145	40	2	437	2	SHANK2	11	70319408	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	3061758	70319408	64687108	118	27618										
MOGAT2	80168	broad.mit.edu	37	chr11	75442218	75442218	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agaagacgctgcatccctcgGaggaggaggtgaaccagctg	15	10	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:75442218G>A	uc010rru.1	+	6	892	c.892G>A	c.(892-894)GAG>AAG	p.E298K	MOGAT2_uc010rrv.1_Missense_Mutation_p.E216K	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	298					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					GCATCCCTCGGAGGAGGAGGT	0.567													0	0	0	0.00499	0	18	39										A	75442218	G	A	75442218	3	1	92	1	0	0	0	0	1	0	0	0	9695	1175	41	1	914	1	MOGAT2	11	75442218	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	5122810	75442218	59564298	119	27619										
PANX1	24145	broad.mit.edu	37	chr11	93911662	93911662	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggaagaacttgacaaagtttAcaaccgtgcaattaaggctg	10	7	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:93911662A>G	uc001per.2	+	3	834	c.449A>G	c.(448-450)TAC>TGC	p.Y150C	PANX1_uc001peq.2_Missense_Mutation_p.Y150C	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	150	Cytoplasmic (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GACAAAGTTTACAACCGTGCA	0.498													0	0	0	0.013537	0	13	47										G	93911662	A	G	93911662	3	3	92	1	0	0	0	0	1	0	0	0	11420	391	14	5	459	5	PANX1	11	93911662	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	18469444	93911662	41094854	120	27620										
PHLDB1	23187	broad.mit.edu	37	chr11	118516477	118516477	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agtggtctggacatggggaaGatcgaggagatggagaagat	18	3	1	4			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:118516477G>C	uc001ptr.1	+	18	3794	c.3441G>C	c.(3439-3441)AAG>AAC	p.K1147N	PHLDB1_uc001pts.2_Missense_Mutation_p.K1147N|PHLDB1_uc001ptt.2_Missense_Mutation_p.K1100N|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Missense_Mutation_p.K962N|PHLDB1_uc001ptw.1_Missense_Mutation_p.K502N|PHLDB1_uc009zai.1_Missense_Mutation_p.K183N|PHLDB1_uc001ptx.1_Missense_Mutation_p.K183N|PHLDB1_uc010ryi.1_3'UTR	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	1147	Potential.										0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACATGGGGAAGATCGAGGAGA	0.612													0	0	0	0.012319	0	21	46										C	118516477	G	C	118516477	3	2	92	1	0	0	0	0	1	0	0	0	11851	933	33	1	3503	1	PHLDB1	11	118516477	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	24604815	118516477	16490039	121	27621										
PANX3	116337	broad.mit.edu	37	chr11	124482880	124482880	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgtgttcctgttgcagggtcTccgatcagctgcttctctcc	10	13	3	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr11:124482880T>C	uc001qah.2	+	2	186	c.186T>C	c.(184-186)TCT>TCC	p.S62S		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	62	Extracellular (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		TTGCAGGGTCTCCGATCAGCT	0.572													0	0	0	0.003163	0	15	41										C	124482880	T	C	124482880	2	2	92	1	0	0	0	0	0	0	0	1	11422	1538	54	5		5	PANX3	11	124482880	Silent	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	5966403	124482880	10523636	122	27622										
CHD4	1108	broad.mit.edu	37	chr12	6691413	6691413	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agccccatctgcccccggctCacataaatgccgcatgaaaa	7	16	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:6691413C>G	uc001qpo.2	-	30	4569	c.4405G>C	c.(4405-4407)GAG>CAG	p.E1469Q	CHD4_uc001qpn.2_Missense_Mutation_p.E1462Q|CHD4_uc001qpp.2_Missense_Mutation_p.E1494Q|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1469					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCCCCGGCTCACATAAATGC	0.473													0	0	0	0.008291	0	10	54										G	6691413	C	G	6691413	3	3	92	1	0	0	0	0	1	0	0	0	3327	835	29	1	1377	1	CHD4	12	6691413	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		6691413	127160482	123	27623										
PDE6H	5149	broad.mit.edu	37	chr12	15131027	15131027	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaaggccctcccaagttcaaGcagaggcagactcgccaatt	9	13	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:15131027G>T	uc001rcr.2	+	2	165	c.81G>T	c.(79-81)AAG>AAT	p.K27N		NM_006205	NP_006196	Q13956	CNCG_HUMAN	phosphodiesterase 6H	27	Arg/Lys-rich (basic).				visual perception		3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			ovary(1)|skin(1)	2						CCAAGTTCAAGCAGAGGCAGA	0.483													1	0	2.0095e-06	0.001984	2.09687e-06	7	21										T	15131027	G	T	15131027	3	4	92	1	0	0	0	0	1	0	0	0	11650	962	34	4	83	4	PDE6H	12	15131027	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	8439614	15131027	118720868	124	27624										
SLCO1B1	10599	broad.mit.edu	37	chr12	21391927	21391927	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctacagaagggtctacttggGcttgtcttcaatgttaagag	11	7	3	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:21391927G>T	uc001req.3	+	15	1984	c.1880G>T	c.(1879-1881)GGC>GTC	p.G627V		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	627	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GTCTACTTGGGCTTGTCTTCA	0.279													1	0	0.00307968	0.00308	0.00312706	8	31										T	21391927	G	T	21391927	3	4	92	1	0	0	0	0	1	0	0	0	14723	1203	42	4	1934	4	SLCO1B1	12	21391927	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	6260900	21391927	112459968	125	27625										
CASC1	55259	broad.mit.edu	37	chr12	25302597	25302597	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgtggctacaccgaatttaaGatgaaggagctcctgcagtt	11	8	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:25302597G>C	uc001rgl.2	-	6	614	c.532C>G	c.(532-534)CTT>GTT	p.L178V	CASC1_uc001rgk.2_Missense_Mutation_p.L184V|CASC1_uc001rgm.3_Missense_Mutation_p.L242V|CASC1_uc001rgj.2_Missense_Mutation_p.L138V|CASC1_uc010sje.1_Missense_Mutation_p.L119V|CASC1_uc010sjf.1_Missense_Mutation_p.L66V|CASC1_uc010sjg.1_Missense_Mutation_p.L178V	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	178										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			CCGAATTTAAGATGAAGGAGC	0.284													0	0	0	0.008291	0	10	34										C	25302597	G	C	25302597	3	2	92	1	0	0	0	0	1	0	0	0	2660	942	33	1	1658	1	CASC1	12	25302597	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	3910670	25302597	108549298	126	27626										
PAN2	9924	broad.mit.edu	37	chr12	56720730	56720730	+	Frame_Shift_Del	DEL	G	G	-													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gccaggcctgtgggttcacaGaattggcactgccctacaaa							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:56720730delG	uc001skx.2	-	7	1306	c.933delC	c.(931-933)TTCfs	p.F311fs	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Frame_Shift_Del_p.F311fs|PAN2_uc001sky.2_Frame_Shift_Del_p.F311fs	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	311					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGGGTTCACAGAATTGGCACT	0.512																		17	44	---	---								-	56720730	G	-	56720730	7	5	92	1	0	1	0	1	0	0	0	0	11414	933	33	0	2755	0	PAN2	12	56720730	Frame_Shift_Del	DEL	G	TCGA-G2-A2EC-01A-11D-A17V-08	31418133	56720730	77131165	127	27627										
KITLG	4254	broad.mit.edu	37	chr12	88900821	88900821	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttaccttccagtataaggctCcaaaagcaaagccaattata	5	10	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:88900821C>G	uc001tav.2	-	7	881	c.698G>C	c.(697-699)GGA>GCA	p.G233A	KITLG_uc009zsn.2_Intron|KITLG_uc001taw.2_Missense_Mutation_p.G205A|KITLG_uc009zso.1_RNA	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	233	Helical; (Potential).				cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1						GTATAAGGCTCCAAAAGCAAA	0.378									Testicular_Cancer_Familial_Clustering_of				0	0	0	0.001168	0	5	40										G	88900821	C	G	88900821	3	3	92	1	0	0	0	0	1	0	0	0	8330	855	30	1	135	1	KITLG	12	88900821	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	32180091	88900821	44951074	128	27628										
ANO4	121601	broad.mit.edu	37	chr12	101510519	101510519	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aatttctgactttgagaaccGatctgagcctgaatctgatg	9	8	3	5			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:101510519G>C	uc010svm.1	+	25	3085	c.2513G>C	c.(2512-2514)CGA>CCA	p.R838P	ANO4_uc001thw.2_Missense_Mutation_p.R803P|ANO4_uc001thx.2_Missense_Mutation_p.R838P|ANO4_uc001thy.2_Missense_Mutation_p.R358P	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	838	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TTTGAGAACCGATCTGAGCCT	0.507										HNSCC(74;0.22)			0	0	0	0.007291	0	29	87										C	101510519	G	C	101510519	3	2	92	1	0	0	0	0	1	0	0	0	699	1058	37	1	2498	1	ANO4	12	101510519	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	12609698	101510519	32341376	129	27629										
MYBPC1	4604	broad.mit.edu	37	chr12	102060550	102060550	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcaaaacagtctgatgaaaaTggggaggctgcctatgatct	12	7	2	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:102060550T>C	uc001tii.2	+	21	2412	c.2310T>C	c.(2308-2310)AAT>AAC	p.N770N	MYBPC1_uc001tig.2_Intron|MYBPC1_uc010svq.1_Intron|MYBPC1_uc001tih.2_Intron|MYBPC1_uc001tij.2_Intron|MYBPC1_uc010svr.1_Intron|MYBPC1_uc010svs.1_Silent_p.N770N|MYBPC1_uc010svt.1_Intron|MYBPC1_uc010svu.1_Intron|MYBPC1_uc001tik.2_Intron|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	770	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CTGATGAAAATGGGGAGGCTG	0.368													0	0	0	0.013537	0	12	59										C	102060550	T	C	102060550	2	2	92	1	0	0	0	0	0	0	0	1	10011	1461	51	5		5	MYBPC1	12	102060550	Silent	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	550031	102060550	31791345	130	27630										
ANAPC7	51434	broad.mit.edu	37	chr12	110825668	110825668	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cattgtcatggatgccacctCtgccccttttacagaaaggg	9	12	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:110825668C>G	uc001tqo.2	-	5	653	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	ANAPC7_uc001tqp.3_Missense_Mutation_p.E218Q	NM_016238	NP_057322	Q9UJX3	APC7_HUMAN	anaphase-promoting complex subunit 7 isoform a	218					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding				0						GATGCCACCTCTGCCCCTTTT	0.473													0	0	0	0.006214	0	9	14										G	110825668	C	G	110825668	3	3	92	1	0	0	0	0	1	0	0	0	606	922	32	1	1179	1	ANAPC7	12	110825668	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	8765118	110825668	23026227	131	27631										
DNAH10	196385	broad.mit.edu	37	chr12	124345622	124345622	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtgagtgtcatagaactctaCggcatcctggacccaaccac	9	13	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr12:124345622C>T	uc001uft.3	+	38	6484	c.6459C>T	c.(6457-6459)TAC>TAT	p.Y2153Y		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2153	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAGAACTCTACGGCATCCTGG	0.493													0	0	0	0.010729	0	11	46										T	124345622	C	T	124345622	2	4	92	1	0	0	0	0	0	0	0	1	4598	547	19	2		2	DNAH10	12	124345622	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	13519954	124345622	9506273	132	27632										
GTF3A	2971	broad.mit.edu	37	chr13	28006890	28006890	+	Frame_Shift_Del	DEL	A	A	-													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtacccaggaaggatgtgggAaacactttgcatcacccagc							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr13:28006890delA	uc001ure.2	+	5	705	c.511delA	c.(511-513)AAAfs	p.K171fs	GTF3A_uc001urf.2_Intron|GTF3A_uc001urg.2_RNA	NM_002097	NP_002088	Q92664	TF3A_HUMAN	transcription factor IIIA	171	C2H2-type 5.				regulation of transcription, DNA-dependent|rRNA transcription|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding|RNA binding|zinc ion binding				0		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.11)|OV - Ovarian serous cystadenocarcinoma(117;0.158)		AGGATGTGGGAAACACTTTGC	0.532																		3	5	---	---								-	28006890	A	-	28006890	7	5	92	1	0	1	0	1	0	0	0	0	6871	247	9	0	529	0	GTF3A	13	28006890	Frame_Shift_Del	DEL	A	TCGA-G2-A2EC-01A-11D-A17V-08		28006890	87162988	133	27633										
FREM2	341640	broad.mit.edu	37	chr13	39263186	39263186	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttctcaatgccaacacggggCtgacactggcagagggtgaa	13	10	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr13:39263186C>A	uc001uwv.2	+	1	2014	c.1705C>A	c.(1705-1707)CTG>ATG	p.L569M		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	569	CSPG 3.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAACACGGGGCTGACACTGGC	0.547													1	0	3.09899e-07	0.004482	3.27253e-07	9	24										A	39263186	C	A	39263186	3	1	92	1	0	0	0	0	1	0	0	0	6045	796	28	4	1707	4	FREM2	13	39263186	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	11256296	39263186	75906692	134	27634										
HAUS4	54930	broad.mit.edu	37	chr14	23419580	23419580	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tttctttttgagctgctcctCtacttcttgctgtagccgag	8	11	3	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:23419580C>G	uc001whp.2	-	5	536	c.505G>C	c.(505-507)GAG>CAG	p.E169Q	HAUS4_uc001who.2_RNA|HAUS4_uc001whq.2_Intron|HAUS4_uc001whr.2_Missense_Mutation_p.E169Q|HAUS4_uc001whs.2_Missense_Mutation_p.E124Q|HAUS4_uc001wht.2_Missense_Mutation_p.E169Q|HAUS4_uc001whu.2_Missense_Mutation_p.E124Q|HAUS4_uc001whv.2_Missense_Mutation_p.E45Q|HAUS4_uc001whw.2_Missense_Mutation_p.E169Q|HAUS4_uc001whx.2_Missense_Mutation_p.E124Q	NM_017815	NP_060285	Q9H6D7	HAUS4_HUMAN	HAUS augmin-like complex, subunit 4	169					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				ovary(1)	1						AGCTGCTCCTCTACTTCTTGC	0.358													0	0	0	0.00308	0	8	26										G	23419580	C	G	23419580	3	3	92	1	0	0	0	0	1	0	0	0	6968	922	32	1	606	1	HAUS4	14	23419580	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		23419580	83929960	135	27635										
KIAA0391	9692	broad.mit.edu	37	chr14	35592881	35592881	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agaccagtttcgaaagttggAtcatttcacagatggctggc	11	8	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:35592881A>G	uc001wsy.1	+	2	790	c.430A>G	c.(430-432)ATC>GTC	p.I144V	KIAA0391_uc010tps.1_Missense_Mutation_p.I49V|KIAA0391_uc001wsz.1_Missense_Mutation_p.I144V|KIAA0391_uc001wta.2_RNA|KIAA0391_uc001wtb.1_Missense_Mutation_p.I144V|KIAA0391_uc001wtc.1_Intron|PPP2R3C_uc001wss.2_5'Flank|PPP2R3C_uc001wst.2_5'Flank|PPP2R3C_uc010tpr.1_5'Flank|PPP2R3C_uc001wsu.2_5'Flank|PPP2R3C_uc010amn.1_5'Flank|PPP2R3C_uc001wsw.2_5'Flank|PPP2R3C_uc001wsx.1_5'Flank	NM_014672	NP_055487	O15091	MRRP3_HUMAN	mitochondrial RNase P protein 3 precursor	144					tRNA processing	mitochondrion					0	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;2.93e-05)|LUAD - Lung adenocarcinoma(48;3.86e-05)|Epithelial(34;0.0114)|all cancers(34;0.0277)	GBM - Glioblastoma multiforme(112;0.0593)		CGAAAGTTGGATCATTTCACA	0.398													0	0	0	0.004482	0	9	64										G	35592881	A	G	35592881	3	3	92	1	0	0	0	0	1	0	0	0	8172	333	12	5	432	5	KIAA0391	14	35592881	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	12173301	35592881	71756659	136	27636										
SYNE2	23224	broad.mit.edu	37	chr14	64625483	64625483	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cctgtggtgttatcattggaGaccttgagatgccaggtgga	14	7	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:64625483G>A	uc001xgm.2	+	86	16163	c.15933G>A	c.(15931-15933)GAG>GAA	p.E5311E	SYNE2_uc001xgl.2_Silent_p.E5311E|SYNE2_uc010apy.2_Silent_p.E1696E|SYNE2_uc001xgn.2_Silent_p.E273E|SYNE2_uc001xgo.2_RNA|SYNE2_uc001xgp.2_Silent_p.E40E	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5311	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATCATTGGAGACCTTGAGAT	0.433													0	0	0	0.016723	0	12	25										A	64625483	G	A	64625483	2	1	92	1	0	0	0	0	0	0	0	1	15443	933	33	1		1	SYNE2	14	64625483	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	29032602	64625483	42724057	137	27637										
STON2	85439	broad.mit.edu	37	chr14	81744349	81744349	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggacatgatgtttttcttctCagggatcctcaacatcattg	8	9	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:81744349C>T	uc010tvu.1	-	4	1507	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	STON2_uc001xvk.1_Missense_Mutation_p.E436K|STON2_uc010tvt.1_Missense_Mutation_p.E233K	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	436	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TTTTTCTTCTCAGGGATCCTC	0.527													0	0	0	0.01441	0	50	110										T	81744349	C	T	81744349	3	4	92	1	0	0	0	0	1	0	0	0	15317	835	29	1	1417	1	STON2	14	81744349	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	17118866	81744349	25605191	138	27638										
TECPR2	9895	broad.mit.edu	37	chr14	102898165	102898165	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tggagatgtctggatgctcaGagcgtgtccacgtgcagcaa	14	9	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:102898165G>C	uc001ylw.1	+	8	1265	c.1117G>C	c.(1117-1119)GAG>CAG	p.E373Q	TECPR2_uc010awl.2_Missense_Mutation_p.E373Q|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	373							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						TGGATGCTCAGAGCGTGTCCA	0.557													0	0	0	0.01892	0	25	70										C	102898165	G	C	102898165	3	2	92	1	0	0	0	0	1	0	0	0	15741	943	33	1	1143	1	TECPR2	14	102898165	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	21153816	102898165	4451375	139	27639										
XRCC3	7517	broad.mit.edu	37	chr14	104177481	104177481	+	Translation_Start_Site	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccaggaaagacagaacaatgGatgcaaattctgaggcactc	10	9	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr14:104177481G>C	uc001yny.3	-	4	324	c.-56C>G	c.(-58--54)ATCCA>ATGCA		XRCC3_uc001ynx.3_Translation_Start_Site|XRCC3_uc001ynz.3_Translation_Start_Site|XRCC3_uc001yoa.3_Translation_Start_Site|XRCC3_uc001yob.1_RNA	NM_005432	NP_005423	O43542	XRCC3_HUMAN	X-ray repair cross complementing protein 3						DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		CAGAACAATGGATGCAAATTC	0.527								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.014758	0	5	9										C	104177481	G	C	104177481	1	2	92	1	0	0	0	0	0	0	0	0	17451	1189	41	1		1	XRCC3	14	104177481	Translation_Start_Site	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1279316	104177481	3172059	140	27640										
FMN1	342184	broad.mit.edu	37	chr15	33192230	33192230	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aatttctaagctatatccatCggcttgtccccgagtcctat	6	12	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:33192230C>T	uc001zhf.3	-	10	2935	c.2935G>A	c.(2935-2937)GAT>AAT	p.D979N		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1202	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		CTATATCCATCGGCTTGTCCC	0.393													0	0	0	0.009718	0	42	112										T	33192230	C	T	33192230	3	4	92	1	0	0	0	0	1	0	0	0	5949	884	31	1	687	1	FMN1	15	33192230	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		33192230	69339162	141	27641										
EIF2AK4	440275	broad.mit.edu	37	chr15	40235658	40235658	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tttgttaaaatctcgcctagAagaactggccaagaaacact	7	9	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:40235658A>G	uc001zkm.1	+	3	382	c.332A>G	c.(331-333)GAA>GGA	p.E111G	EIF2AK4_uc001zkl.2_Missense_Mutation_p.E111G	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	111	RWD.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCTCGCCTAGAAGAACTGGCC	0.338													0	0	0	0.004007	0	15	42										G	40235658	A	G	40235658	3	3	92	1	0	0	0	0	1	0	0	0	4999	246	9	5	342	5	EIF2AK4	15	40235658	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	7043428	40235658	62295734	142	27642										
BMF	90427	broad.mit.edu	37	chr15	40396430	40396430	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctgcaatgcactgaagctttCgggcaatctgtacctctgct	9	12	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:40396430C>T	uc001zkv.2	-	3	490	c.404G>A	c.(403-405)CGA>CAA	p.R135Q	BMF_uc001zkt.2_Intron|BMF_uc001zku.2_Intron|BMF_uc001zkw.2_Missense_Mutation_p.R135Q	NM_033503	NP_277038	Q96LC9	BMF_HUMAN	Bcl2 modifying factor isoform bmf-1	135	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			ovary(1)	1		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		CTGAAGCTTTCGGGCAATCTG	0.597													0	0	0	0.005443	0	28	93										T	40396430	C	T	40396430	3	4	92	1	0	0	0	0	1	0	0	0	1454	884	31	1	158	1	BMF	15	40396430	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	160772	40396430	62134962	143	27643										
MGA	23269	broad.mit.edu	37	chr15	42042440	42042440	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaagacatgtcaggaaaattCagatgtgtttcagcaagaac	9	6	3	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:42042440C>G	uc010ucy.1	+	17	6816	c.6635C>G	c.(6634-6636)TCA>TGA	p.S2212*	MGA_uc010ucz.1_Nonsense_Mutation_p.S2003*|MGA_uc010uda.1_Nonsense_Mutation_p.S828*|MGA_uc001zoi.2_Nonsense_Mutation_p.S426*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2173	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CAGGAAAATTCAGATGTGTTT	0.398													0	0	0	0.013726	0	31	66										G	42042440	C	G	42042440	4	3	92	1	0	0	0	0	0	1	0	0	9540	838	29	1	6697	1	MGA	15	42042440	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1646010	42042440	60488952	144	27644										
STRC	161497	broad.mit.edu	37	chr15	43896298	43896298	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtccaactctgctctgctccCagctctgctgcttttctaga	7	15	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:43896298C>T	uc001zsf.2	-	22	4349	c.4271G>A	c.(4270-4272)TGG>TAG	p.W1424*	STRC_uc010bdl.2_Nonsense_Mutation_p.W651*|STRC_uc001zse.2_5'UTR	NM_153700	NP_714544	Q7RTU9	STRC_HUMAN	stereocilin precursor	1424					sensory perception of sound	cell surface					0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCTCTGCTCCCAGCTCTGCTG	0.582													0	0	0	0.008291	0	8	27										T	43896298	C	T	43896298	4	4	92	1	0	0	0	0	0	1	0	0	15327	595	21	2	1088	2	STRC	15	43896298	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1853858	43896298	58635094	145	27645										
DUOX2	50506	broad.mit.edu	37	chr15	45396470	45396470	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcccagggactcggcaaactCggccctgctcagctcgcagg	13	16	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:45396470C>T	uc010bea.2	-	19	2631	c.2428G>A	c.(2428-2430)GAG>AAG	p.E810K	DUOX2_uc001zun.2_Missense_Mutation_p.E810K	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	810	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		TCGGCAAACTCGGCCCTGCTC	0.627													0	0	0	0.016723	0	12	14										T	45396470	C	T	45396470	3	4	92	1	0	0	0	0	1	0	0	0	4801	893	31	1	2282	1	DUOX2	15	45396470	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1500172	45396470	57134922	146	27646										
TMC3	342125	broad.mit.edu	37	chr15	81625286	81625286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggacccgggatgcatattgtCgcacgttcctggggtacagc	14	11	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr15:81625286C>T	uc002bgo.1	-	22	2777	c.2777G>A	c.(2776-2778)CGA>CAA	p.R926Q	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	926	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TGCATATTGTCGCACGTTCCT	0.512													0	0	0	0.006122	0	17	36										T	81625286	C	T	81625286	3	4	92	1	0	0	0	0	1	0	0	0	15983	884	31	1	529	1	TMC3	15	81625286	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	36228816	81625286	20906106	147	27647										
WDR90	197335	broad.mit.edu	37	chr16	708543	708543	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agctgcccggtgtccaccctGagccctgcccctccttgacg	10	19	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:708543G>A	uc002cii.1	+	23	2839	c.2785G>A	c.(2785-2787)GAG>AAG	p.E929K	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Missense_Mutation_p.E456K|WDR90_uc002cil.1_RNA|WDR90_uc002cim.1_Missense_Mutation_p.E103K|WDR90_uc002cin.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	929	WD 10.									ovary(1)	1		Hepatocellular(780;0.0218)				TGTCCACCCTGAGCCCTGCCC	0.662													0	0	0	0.009535	0	29	67										A	708543	G	A	708543	3	1	92	1	0	0	0	0	1	0	0	0	17334	1291	45	1	2875	1	WDR90	16	708543	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		708543	89646210	148	27648										
RBBP6	5930	broad.mit.edu	37	chr16	24578570	24578570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttccaccacctcctttgtatCcgcctcctccccatacactt	2	20	0	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:24578570C>T	uc002dmh.2	+	15	2736	c.1696C>T	c.(1696-1698)CCG>TCG	p.P566S	RBBP6_uc010vcb.1_Missense_Mutation_p.P433S|RBBP6_uc002dmi.2_Missense_Mutation_p.P566S|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.P433S	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	566					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		tcctttgtatccgcctcctcc	0.299													0	0	0	0.008871	0	21	84										T	24578570	C	T	24578570	3	4	92	1	0	0	0	0	1	0	0	0	13103	855	30	1	1808	1	RBBP6	16	24578570	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	23870027	24578570	65776183	149	27649										
NSMCE1	197370	broad.mit.edu	37	chr16	27246536	27246536	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcccatcatcttccgtgactCctctctttatctcaatatac	2	15	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:27246536C>T	uc002doi.1	-	3	319	c.221G>A	c.(220-222)GGA>GAA	p.G74E	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	74					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						TTCCGTGACTCCTCTCTTTAT	0.493											OREG0023693	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	34										T	27246536	C	T	27246536	3	4	92	1	0	0	0	0	1	0	0	0	10675	855	30	1	603	1	NSMCE1	16	27246536	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	2667966	27246536	63108217	150	27650										
TAOK2	9344	broad.mit.edu	37	chr16	29998793	29998793	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggtggctatggcagcgggggGcagatgggtgcggcagcagg	23	7	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:29998793G>A	uc002dva.1	+	16	3983	c.3200G>A	c.(3199-3201)GGC>GAC	p.G1067D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.G1074D|TAOK2_uc002dvd.1_Missense_Mutation_p.G894D	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	1067					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCAGCGGGGGGCAGATGGGTG	0.692													0	0	0	0.00308	0	6	31										A	29998793	G	A	29998793	3	1	92	1	0	0	0	0	1	0	0	0	15545	1203	42	2	3258	2	TAOK2	16	29998793	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	2752257	29998793	60355960	151	27651										
HSD3B7	80270	broad.mit.edu	37	chr16	30997087	30997087	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctgcagcgggagccccggctCggggagctgcgggtctttga	18	12	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:30997087C>T	uc002eaf.2	+	2	214	c.108C>T	c.(106-108)CTC>CTT	p.L36L	HSD3B7_uc010cac.2_Silent_p.L36L|HSD3B7_uc002eag.2_Silent_p.L36L|HSD3B7_uc002eah.2_Silent_p.L36L	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	36					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						AGCCCCGGCTCGGGGAGCTGC	0.642													0	0	0	0.014758	0	5	6										T	30997087	C	T	30997087	2	4	92	1	0	0	0	0	0	0	0	1	7392	871	31	1		1	HSD3B7	16	30997087	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	998294	30997087	59357666	152	27652										
SLC12A3	6559	broad.mit.edu	37	chr16	56901090	56901090	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccagcagcgagaagaaccccGaggagccagtgcgcttcggc	14	14	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:56901090G>A	uc010ccm.2	+	2	420	c.391G>A	c.(391-393)GAG>AAG	p.E131K	SLC12A3_uc002ekd.3_Missense_Mutation_p.E131K|SLC12A3_uc010ccn.2_Missense_Mutation_p.E130K	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	131	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GAAGAACCCCGAGGAGCCAGT	0.652													0	0	0	0.004672	0	3	8										A	56901090	G	A	56901090	3	1	92	1	0	0	0	0	1	0	0	0	14384	1059	37	1	397	1	SLC12A3	16	56901090	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	25904003	56901090	33453663	153	27653										
GINS3	64785	broad.mit.edu	37	chr16	58438619	58438619	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	acaagaagagaaaattcactGatatggaagactgaaagccg	10	6	1	5	rs144642422		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:58438619G>C	uc002enh.3	+	3	845	c.637G>C	c.(637-639)GAT>CAT	p.D213H	GINS3_uc010cdj.2_Missense_Mutation_p.D252H|GINS3_uc002enj.3_Missense_Mutation_p.D135H|GINS3_uc002eni.3_3'UTR	NM_022770	NP_073607	Q9BRX5	PSF3_HUMAN	GINS complex subunit 3 isoform b	213					DNA replication	nucleus					0						AAAATTCACTGATATGGAAGA	0.478													0	0	0	0.001984	0	7	19										C	58438619	G	C	58438619	3	2	92	1	0	0	0	0	1	0	0	0	6389	1290	45	1	768	1	GINS3	16	58438619	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1537529	58438619	31916134	154	27654										
PARD6A	50855	broad.mit.edu	37	chr16	67696467	67696467	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	atcctggtacccgcagctctCtgccctccctggatgaccag	9	17	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:67696467C>T	uc002ett.2	+	3	1049	c.958C>T	c.(958-960)CTG>TTG	p.L320L	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Silent_p.L319L|PARD6A_uc002etu.2_Silent_p.L144L	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	320					cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCGCAGCTCTCTGCCCTCCCT	0.637													0	0	0	0.010729	0	9	19										T	67696467	C	T	67696467	2	4	92	1	0	0	0	0	0	0	0	1	11445	912	32	1		1	PARD6A	16	67696467	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	9257848	67696467	22658286	155	27655										
ESRP2	80004	broad.mit.edu	37	chr16	68264333	68264333	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gagcagatccttcataccagCcgtgtatgggacaccctgca	10	13	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr16:68264333C>G	uc010cfa.1	-	14	2241	c.2053G>C	c.(2053-2055)GCT>CCT	p.A685P	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Missense_Mutation_p.A675P	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	685					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						TTCATACCAGCCGTGTATGGG	0.617													0	0	0	0.014323	0	24	55										G	68264333	C	G	68264333	3	3	92	1	0	0	0	0	1	0	0	0	5259	739	26	4	138	4	ESRP2	16	68264333	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	567866	68264333	22090420	156	27656										
SGK494	124923	broad.mit.edu	37	chr17	26940312	26940312	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tacagctttctgggtgcaatCtagcaccttgaggacagttc	10	10	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26940312C>G	uc002hbr.1	-	3	408	c.376G>C	c.(376-378)GAT>CAT	p.D126H	SGK494_uc010waq.1_Missense_Mutation_p.D126H|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						TGGGTGCAATCTAGCACCTTG	0.458											OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.021523	0	23	39										G	26940312	C	G	26940312	3	3	92	1	0	0	0	0	1	0	0	0	14213	913	32	1	896	1	SGK494	17	26940312	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08		26940312	54254898	157	27657			1	122		6	5	5516	N	C	8.064228e-08
SGK494	124923	broad.mit.edu	37	chr17	26940461	26940461	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggattccactgacttaccttCagctgctgctgccccctaat	7	15	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26940461C>T	uc002hbr.1	-	2	353	c.321G>A	c.(319-321)CTG>CTA	p.L107L	SGK494_uc010waq.1_Silent_p.L107L|SGK494_uc010war.1_RNA|uc010crq.1_5'Flank|uc002hbs.1_Intron	NM_144610	NP_653211			uncharacterized serine/threonine-protein kinase												0						GACTTACCTTCAGCTGCTGCT	0.502											OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	20	41										T	26940461	C	T	26940461	2	4	92	1	0	0	0	0	0	0	0	1	14213	813	29	1		1	SGK494	17	26940461	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	149	26940461	54254749	158	27658			1	122		6	5	5516	N	C	8.064228e-08
KIAA0100	9703	broad.mit.edu	37	chr17	26942708	26942708	+	Missense_Mutation	SNP	C	C	A													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaccagggctttgcggctgtCccttttgacagccatggcaa							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26942708C>A	uc002hbu.2	-	38	6598	c.6499G>T	c.(6499-6501)GAC>TAC	p.D2167Y	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.D496Y	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2167						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTGCGGCTGTCCCTTTTGACA	0.557													1	0	6.40141e-05	0.010729	6.57577e-05	11	39										A	26942708	C	A	26942708	3	1	92	1	0	0	0	0	1	0	0	0	8154	855	30	3	216	3	KIAA0100	17	26942708	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	2247	26942708	54252502	159	27659	137	2	1	122		6	5	5516	N	C	8.064228e-08
KIAA0100	9703	broad.mit.edu	37	chr17	26942717	26942717	+	Missense_Mutation	SNP	C	C	T													0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tttgcggctgtcccttttgaCagccatggcaaagtctagcc							TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26942717C>T	uc002hbu.2	-	38	6589	c.6490G>A	c.(6490-6492)GTC>ATC	p.V2164I	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.V493I	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2164						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TCCCTTTTGACAGCCATGGCA	0.567													0	0	0	0.013537	0	13	34										T	26942717	C	T	26942717	3	4	92	1	0	0	0	0	1	0	0	0	8154	478	17	2	225	2	KIAA0100	17	26942717	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	9	26942717	54252493	160	27660	137	2	1	122		6	5	5516	N	C	8.064228e-08
KIAA0100	9703	broad.mit.edu	37	chr17	26943203	26943203	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctctttcatcttgtcaatgtCatccacagggtgctaagaaa	7	10	5	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26943203C>T	uc002hbu.2	-	37	6400	c.6301G>A	c.(6301-6303)GAC>AAC	p.D2101N	SGK494_uc010waq.1_5'Flank|SGK494_uc010war.1_5'Flank|SGK494_uc002hbr.1_5'Flank|uc002hbs.1_Intron|KIAA0100_uc002hbt.2_Missense_Mutation_p.D430N	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	2101						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TTGTCAATGTCATCCACAGGG	0.478													0	0	0	0.008291	0	11	28										T	26943203	C	T	26943203	3	4	92	1	0	0	0	0	1	0	0	0	8154	826	29	1	418	1	KIAA0100	17	26943203	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	486	26943203	54252007	161	27661			1	122		6	5	5516	N	C	8.064228e-08
KIAA0100	9703	broad.mit.edu	37	chr17	26945827	26945827	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	accttgctgtagaggaacctCtgcagttctaattcagcaat	8	10	3	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:26945827C>G	uc002hbu.2	-	32	5904	c.5805G>C	c.(5803-5805)CAG>CAC	p.Q1935H	KIAA0100_uc002hbt.2_Missense_Mutation_p.Q264H	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1935						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGAGGAACCTCTGCAGTTCTA	0.478													0	0	0	0.005443	0	24	56										G	26945827	C	G	26945827	3	3	92	1	0	0	0	0	1	0	0	0	8154	912	32	1	934	1	KIAA0100	17	26945827	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	2624	26945827	54249383	162	27662			1	122		6	5	5516	N	C	8.064228e-08
SUPT6H	6830	broad.mit.edu	37	chr17	27008291	27008291	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caggctcaaggatgtccaatCaatggatgagctgaaagatg	12	7	2	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:27008291C>G	uc002hby.2	+	12	1457	c.1367C>G	c.(1366-1368)TCA>TGA	p.S456*	SUPT6H_uc010crt.2_Nonsense_Mutation_p.S456*	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	456					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GATGTCCAATCAATGGATGAG	0.443													0	0	0	0.010504	0	20	41										G	27008291	C	G	27008291	4	3	92	1	0	0	0	0	0	1	0	0	15397	838	29	1	1409	1	SUPT6H	17	27008291	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	62464	27008291	54186919	163	27663										
TP53I13	90313	broad.mit.edu	37	chr17	27895814	27895814	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ttcgccccaactgcttctccTggcagccctcgcgaggctcc	9	19	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:27895814T>C	uc002hee.2	+	1	76	c.38T>C	c.(37-39)CTG>CCG	p.L13P	ABHD15_uc002hed.1_5'Flank	NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	13						cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		CTGCTTCTCCTGGCAGCCCTC	0.468													0	0	0	0.020292	0	13	18										C	27895814	T	C	27895814	3	2	92	1	0	0	0	0	1	0	0	0	16383	1580	55	5	40	5	TP53I13	17	27895814	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	887523	27895814	53299396	164	27664										
AP2B1	163	broad.mit.edu	37	chr17	33966732	33966732	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaagaattgacaatgcagatGagttactagaaagcttcctg	9	6	0	5			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:33966732G>A	uc002hjr.2	+	11	1579	c.1390G>A	c.(1390-1392)GAG>AAG	p.E464K	AP2B1_uc002hjq.2_Missense_Mutation_p.E464K|AP2B1_uc010wci.1_Missense_Mutation_p.E426K|AP2B1_uc002hjs.2_Missense_Mutation_p.E407K|AP2B1_uc002hjt.2_Missense_Mutation_p.E464K|AP2B1_uc010ctv.2_Missense_Mutation_p.E464K|AP2B1_uc010wcj.1_Missense_Mutation_p.E201K	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	464					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CAATGCAGATGAGTTACTAGA	0.438													0	0	0	0.004007	0	16	50										A	33966732	G	A	33966732	3	1	92	1	0	0	0	0	1	0	0	0	741	1291	45	1	1428	1	AP2B1	17	33966732	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	6070918	33966732	47228478	165	27665										
AATF	26574	broad.mit.edu	37	chr17	35310257	35310257	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgggtctggaggaatatgatGaggacgacctgggtgctgct	17	6	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:35310257G>A	uc002hni.2	+	3	606	c.355G>A	c.(355-357)GAG>AAG	p.E119K	AATF_uc002hnj.2_RNA	NM_012138	NP_036270	Q9NY61	AATF_HUMAN	apoptosis antagonizing transcription factor	119	Glu-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)				GGAATATGATGAGGACGACCT	0.498													0	0	0	0.013537	0	12	49										A	35310257	G	A	35310257	3	1	92	1	0	0	0	0	1	0	0	0	25	1291	45	1	365	1	AATF	17	35310257	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1343525	35310257	45884953	166	27666										
CACNB1	782	broad.mit.edu	37	chr17	37343111	37343111	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cgaaggctgtccagtttgacGgggctgggaatgaagccaac	15	9	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:37343111G>A	uc002hrm.1	-	5	639	c.486C>T	c.(484-486)CCC>CCT	p.P162P	CACNB1_uc002hrl.1_5'UTR|CACNB1_uc002hrn.2_Silent_p.P162P|CACNB1_uc002hro.2_Silent_p.P162P|CACNB1_uc002hrp.1_Silent_p.P162P|CACNB1_uc010web.1_Silent_p.P115P	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	162					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCAGTTTGACGGGGCTGGGAA	0.592													0	0	0	0.014323	0	22	40										A	37343111	G	A	37343111	2	1	92	1	0	0	0	0	0	0	0	1	2552	1103	39	2		2	CACNB1	17	37343111	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	2032854	37343111	43852099	167	27667										
FBXL20	84961	broad.mit.edu	37	chr17	37431242	37431242	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cctaagccgtgggcagttctGacctagagcattcaggatgg	13	10	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:37431242G>C	uc010wed.1	-	10	1029	c.808C>G	c.(808-810)CAG>GAG	p.Q270E	FBXL20_uc002hrt.2_Missense_Mutation_p.Q270E|FBXL20_uc010cvu.2_Missense_Mutation_p.Q238E	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	270	LRR 8.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			GGGCAGTTCTGACCTAGAGCA	0.418													0	0	0	0.010729	0	11	48										C	37431242	G	C	37431242	3	2	92	1	0	0	0	0	1	0	0	0	5717	1299	45	1	526	1	FBXL20	17	37431242	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	88131	37431242	43763968	168	27668										
CDK12	51755	broad.mit.edu	37	chr17	37618889	37618889	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agaagaccaggaaagaacggGagctgaagtctgggcacaaa	14	7	1	4			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:37618889G>A	uc010cvv.2	+	1	1151	c.565G>A	c.(565-567)GAG>AAG	p.E189K	CDK12_uc010wef.1_Missense_Mutation_p.E189K|CDK12_uc002hrw.3_Missense_Mutation_p.E189K	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	189					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GAAAGAACGGGAGCTGAAGTC	0.502										TCGA Ovarian(9;0.13)			0	0	0	0.004482	0	8	28										A	37618889	G	A	37618889	3	1	92	1	0	0	0	0	1	0	0	0	3128	1175	41	1	567	1	CDK12	17	37618889	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	187647	37618889	43576321	169	27669										
COASY	80347	broad.mit.edu	37	chr17	40717318	40717318	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccgagaggagatggatcgggCtgtggctgagggtgagtggg	22	5	0	4			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:40717318C>G	uc002hzz.2	+	7	1533	c.1376C>G	c.(1375-1377)GCT>GGT	p.A459G	COASY_uc010cyj.2_Missense_Mutation_p.A488G|COASY_uc002iab.2_Missense_Mutation_p.A164G|COASY_uc002iad.2_Missense_Mutation_p.A459G|COASY_uc002iac.2_Missense_Mutation_p.A459G|COASY_uc002iae.2_Missense_Mutation_p.A254G|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	459	DPCK.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		ATGGATCGGGCTGTGGCTGAG	0.577													0	0	0	0.014758	0	5	94										G	40717318	C	G	40717318	3	3	92	1	0	0	0	0	1	0	0	0	3652	797	28	4	1489	4	COASY	17	40717318	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3098429	40717318	40477892	170	27670										
ITGA2B	3674	broad.mit.edu	37	chr17	42463435	42463435	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggccctccaggggcacaggaAcacgccgcccgtctcctcct	11	19	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:42463435A>G	uc002igt.1	-	2	285	c.253T>C	c.(253-255)TTC>CTC	p.F85L		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	85	Extracellular (Potential).|FG-GAP 1.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGCACAGGAACACGCCGCCC	0.697													0	0	0	0.004672	0	3	10										G	42463435	A	G	42463435	3	3	92	1	0	0	0	0	1	0	0	0	7876	43	2	5	2982	5	ITGA2B	17	42463435	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	1746117	42463435	38731775	171	27671										
ITGB3	3690	broad.mit.edu	37	chr17	45387520	45387520	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cacaggccaacaacccactgTataaagaggccacgtctacc	7	15	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:45387520T>C	uc002ilj.2	+	15	2337	c.2317T>C	c.(2317-2319)TAT>CAT	p.Y773H	ITGB3_uc010wkr.1_Intron	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	773	Cytoplasmic (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	CAACCCACTGTATAAAGAGGC	0.448													0	0	0	0.00499	0	14	35										C	45387520	T	C	45387520	3	2	92	1	0	0	0	0	1	0	0	0	7895	1638	57	5	2375	5	ITGB3	17	45387520	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	2924085	45387520	35807690	172	27672										
KPNB1	3837	broad.mit.edu	37	chr17	45727754	45727754	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccactttcctccccctagatCggctggagctggaagcggcg	12	15	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:45727754C>G	uc002ilt.1	+	2	379	c.43C>G	c.(43-45)CGG>GGG	p.R15G	KPNB1_uc010wkw.1_5'Flank	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	15					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CCCCCTAGATCGGCTGGAGCT	0.721													0	0	0	0.009096	0	4	12										G	45727754	C	G	45727754	3	3	92	1	0	0	0	0	1	0	0	0	8435	875	31	1	49	1	KPNB1	17	45727754	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	340234	45727754	35467456	173	27673										
MRPL10	124995	broad.mit.edu	37	chr17	45901691	45901691	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agctggaggggctggtgctgGagcagggagtgggtctgggc	23	6	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:45901691G>C	uc002ilz.2	-	5	692	c.666C>G	c.(664-666)CTC>CTG	p.L222L	OSBPL7_uc002ilx.1_5'Flank|MRPL10_uc010wky.1_Silent_p.L183L|MRPL10_uc002ily.2_Silent_p.L232L	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	222					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						GCTGGTGCTGGAGCAGGGAGT	0.607													0	0	0	0.020292	0	13	42										C	45901691	G	C	45901691	2	2	92	1	0	0	0	0	0	0	0	1	9775	1161	41	1		1	MRPL10	17	45901691	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	173937	45901691	35293519	174	27674										
ANKFN1	162282	broad.mit.edu	37	chr17	54526504	54526504	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	agtgaagttttggaaggtctGctgcagcaggtccgagccct	14	9	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:54526504G>A	uc002iun.1	+	10	1208	c.1173G>A	c.(1171-1173)CTG>CTA	p.L391L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	391										large_intestine(1)|ovary(1)	2						TGGAAGGTCTGCTGCAGCAGG	0.468													0	0	0	0.008871	0	17	47										A	54526504	G	A	54526504	2	1	92	1	0	0	0	0	0	0	0	1	625	1306	46	2		2	ANKFN1	17	54526504	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	8624813	54526504	26668706	175	27675										
BCAS3	54828	broad.mit.edu	37	chr17	59067473	59067473	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caccacgagtagtgaatcgcAtgagccgtttccagaaaagt	10	10	0	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:59067473A>G	uc002iyv.3	+	15	1472	c.1363A>G	c.(1363-1365)ATG>GTG	p.M455V	BCAS3_uc010wow.1_Missense_Mutation_p.M242V|BCAS3_uc002iyu.3_Missense_Mutation_p.M455V|BCAS3_uc002iyw.3_Missense_Mutation_p.M451V|BCAS3_uc002iyx.1_Missense_Mutation_p.M270V|BCAS3_uc002iyy.3_Missense_Mutation_p.M226V|BCAS3_uc002iyz.3_Missense_Mutation_p.M9V|BCAS3_uc002iza.3_Missense_Mutation_p.M9V	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	455						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGTGAATCGCATGAGCCGTTT	0.512													0	0	0	0.004007	0	17	38										G	59067473	A	G	59067473	3	3	92	1	0	0	0	0	1	0	0	0	1352	217	8	5	1417	5	BCAS3	17	59067473	Missense_Mutation	SNP	A	TCGA-G2-A2EC-01A-11D-A17V-08	4540969	59067473	22127737	176	27676										
LRRC37A3	374819	broad.mit.edu	37	chr17	62864655	62864655	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctagcgttgttcccatgtctCtgaagaagaaagccgaaaca	9	10	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:62864655C>G	uc002jey.2	-	9	3510	c.2979_splice	c.e9-1	p.L993_splice	LRRC37A3_uc010wqg.1_Splice_Site_p.L111_splice|LRRC37A3_uc010wqf.1_Splice_Site_p.L31_splice|LRRC37A3_uc010dek.1_Splice_Site	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3							integral to membrane					0						TCCCATGTCTCTGAAGAAGAA	0.353													0	0	0	0.005443	0	21	69										G	62864655	C	G	62864655	5	3	92	1	0	0	0	0	0	0	1	0	8993	927	32	1	1950	1	LRRC37A3	17	62864655	Splice_Site	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3797182	62864655	18330555	177	27677										
NUP85	79902	broad.mit.edu	37	chr17	73231679	73231679	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tctctgctttgcaggatgatGacatagagaccaccaaggtg	11	9	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr17:73231679G>A	uc002jng.1	+	19	2136	c.1876G>A	c.(1876-1878)GAC>AAC	p.D626N	NUP85_uc010dgd.1_Missense_Mutation_p.D581N|NUP85_uc010wrv.1_Missense_Mutation_p.D580N|NUP85_uc002jnh.1_Missense_Mutation_p.D229N	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	626					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GCAGGATGATGACATAGAGAC	0.502													0	0	0	0.014323	0	19	31										A	73231679	G	A	73231679	3	1	92	1	0	0	0	0	1	0	0	0	10770	1290	45	1	1950	1	NUP85	17	73231679	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	10367024	73231679	7963531	178	27678										
COLEC12	81035	broad.mit.edu	37	chr18	346369	346369	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tcatttcttccataatcactGataagttggctacttcagtg	6	9	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:346369G>A	uc002kkm.2	-	5	1468	c.1253C>T	c.(1252-1254)TCA>TTA	p.S418L		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	418	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CATAATCACTGATAAGTTGGC	0.378													0	0	0	0.001984	0	7	53										A	346369	G	A	346369	3	1	92	1	0	0	0	0	1	0	0	0	3712	1294	45	1	999	1	COLEC12	18	346369	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		346369	77730879	179	27679										
MYOM1	8736	broad.mit.edu	37	chr18	3119940	3119940	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggcgcgcccagcccagccatGttcatggctgccacttggaa	12	15	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:3119940G>A	uc002klp.2	-	20	3379	c.3045C>T	c.(3043-3045)AAC>AAT	p.N1015N	MYOM1_uc002klq.2_Silent_p.N919N	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1015	Fibronectin type-III 4.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GCCCAGCCATGTTCATGGCTG	0.502													0	0	0	0.014758	0	3	4										A	3119940	G	A	3119940	2	1	92	1	0	0	0	0	0	0	0	1	10091	1368	48	2		2	MYOM1	18	3119940	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	2773571	3119940	74957308	180	27680										
LAMA3	3909	broad.mit.edu	37	chr18	21395492	21395492	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	attcctgcgacacctgtgaaGatggatattttgctttggaa	10	7	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:21395492G>C	uc002kuq.2	+	17	2088	c.2002G>C	c.(2002-2004)GAT>CAT	p.D668H	LAMA3_uc002kur.2_Missense_Mutation_p.D668H	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	668	Domain V.|Laminin EGF-like 7.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTGTGAAGATGGATATTT	0.453													0	0	0	0.004482	0	9	36										C	21395492	G	C	21395492	3	2	92	1	0	0	0	0	1	0	0	0	8607	942	33	1	2068	1	LAMA3	18	21395492	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	18275552	21395492	56681756	181	27681										
LAMA3	3909	broad.mit.edu	37	chr18	21396406	21396406	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catgtgcagtgggccctcggGagtgtgccagtgccgagagc	17	11	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:21396406G>T	uc002kuq.2	+	18	2188	c.2102G>T	c.(2101-2103)GGA>GTA	p.G701V	LAMA3_uc002kur.2_Missense_Mutation_p.G701V	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	701	Domain V.|Laminin EGF-like 8.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGCCCTCGGGAGTGTGCCAG	0.552													1	0	2.68362e-12	0.013537	2.89174e-12	10	28										T	21396406	G	T	21396406	3	4	92	1	0	0	0	0	1	0	0	0	8607	1174	41	3	2172	3	LAMA3	18	21396406	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	914	21396406	56680842	182	27682										
SLC14A2	8170	broad.mit.edu	37	chr18	43205653	43205653	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggtttctcctaaaaggatctCcggtcttccaatgaagacag	9	10	3	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr18:43205653C>G	uc010dnj.2	+	4	477	c.156C>G	c.(154-156)CTC>CTG	p.L52L	SLC14A2_uc002lbb.2_Silent_p.L52L|SLC14A2_uc002lbe.2_Silent_p.L52L	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	52						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						AAAAGGATCTCCGGTCTTCCA	0.468													0	0	0	0.010729	0	10	20										G	43205653	C	G	43205653	2	3	92	1	0	0	0	0	0	0	0	1	14397	842	30	1		1	SLC14A2	18	43205653	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	21809247	43205653	34871595	183	27683										
ZNF266	10781	broad.mit.edu	37	chr19	9528554	9528554	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	actcttcttgttccagccaaGagatcagactgggtttgaag	10	9	3	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:9528554G>A	uc002mll.2	-	2	331	c.65C>T	c.(64-66)TCT>TTT	p.S22F	ZNF266_uc002mlm.2_Missense_Mutation_p.S22F|ZNF266_uc002mln.2_Missense_Mutation_p.S22F|ZNF266_uc002mlo.2_Missense_Mutation_p.S22F|ZNF266_uc010dwp.2_Missense_Mutation_p.S22F|ZNF266_uc010dwq.2_Missense_Mutation_p.S22F	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	22	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCCAGCCAAGAGATCAGACT	0.433													0	0	0	0.011902	0	44	89										A	9528554	G	A	9528554	3	1	92	1	0	0	0	0	1	0	0	0	17802	942	33	1	1596	1	ZNF266	19	9528554	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		9528554	49600429	184	27684										
ZNF121	7675	broad.mit.edu	37	chr19	9676748	9676748	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgtgaagaagcacggaaggtTttcccacattccttacatat	8	9	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:9676748T>A	uc010xkp.1	-	4	1273	c.1041A>T	c.(1039-1041)AAA>AAT	p.K347N	ZNF121_uc010dwt.2_Missense_Mutation_p.K347N|ZNF121_uc010xkq.1_Missense_Mutation_p.K347N	NM_001008727	NP_001008727	P58317	ZN121_HUMAN	zinc finger protein 121	347	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CACGGAAGGTTTTCCCACATT	0.388													0	0	0	0.004007	0	16	36										A	9676748	T	A	9676748	3	1	92	1	0	0	0	0	1	0	0	0	17716	1838	64	5	135	5	ZNF121	19	9676748	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	148194	9676748	49452235	185	27685										
ANGPTL6	83854	broad.mit.edu	37	chr19	10204373	10204373	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcccacctgtgcccaccttaTagtgctgccaggtagtgaag	11	13	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:10204373T>C	uc002mmx.1	-	4	1065	c.947A>G	c.(946-948)TAT>TGT	p.Y316C	ANGPTL6_uc002mmy.1_Missense_Mutation_p.Y316C	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	316	Fibrinogen C-terminal.				angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GCCCACCTTATAGTGCTGCCA	0.607													0	0	0	0.010729	0	12	57										C	10204373	T	C	10204373	3	2	92	1	0	0	0	0	1	0	0	0	618	1406	49	5	477	5	ANGPTL6	19	10204373	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	527625	10204373	48924610	186	27686										
ICAM1	3383	broad.mit.edu	37	chr19	10395527	10395527	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cagaaaattcccagcagactCcaatgtgccaggcttggggg	12	11	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:10395527C>G	uc002mnq.2	+	6	1568	c.1249C>G	c.(1249-1251)CCA>GCA	p.P417A	ICAM1_uc010xle.1_Missense_Mutation_p.P195A|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	417	Extracellular (Potential).|Ig-like C2-type 5.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	CCAGCAGACTCCAATGTGCCA	0.557													0	0	0	0.003163	0	15	34										G	10395527	C	G	10395527	3	3	92	1	0	0	0	0	1	0	0	0	7479	855	30	1	1271	1	ICAM1	19	10395527	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	191154	10395527	48733456	187	27687										
ICAM1	3383	broad.mit.edu	37	chr19	10395565	10395565	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gggaacccattgcccgagctCaagtgtctaaaggatggcac	12	11	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:10395565C>G	uc002mnq.2	+	6	1606	c.1287C>G	c.(1285-1287)CTC>CTG	p.L429L	ICAM1_uc010xle.1_Silent_p.L207L|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	429	Extracellular (Potential).|Ig-like C2-type 5.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	TGCCCGAGCTCAAGTGTCTAA	0.582													0	0	0	0.016723	0	13	25										G	10395565	C	G	10395565	2	3	92	1	0	0	0	0	0	0	0	1	7479	813	29	1		1	ICAM1	19	10395565	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	38	10395565	48733418	188	27688										
EPOR	2057	broad.mit.edu	37	chr19	11488763	11488763	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cggataagcccccttgggctCcctgggagtcccctgagctg	13	15	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:11488763C>T	uc002mrj.1	-	8	1560	c.1424G>A	c.(1423-1425)GGA>GAA	p.G475E	EPOR_uc002mrh.2_Missense_Mutation_p.G134E|EPOR_uc002mri.2_Missense_Mutation_p.G302E|EPOR_uc002mrk.1_Missense_Mutation_p.G302E|EPOR_uc002mrl.1_RNA|EPOR_uc010xlx.1_RNA|EPOR_uc010xly.1_Missense_Mutation_p.G302E	NM_000121	NP_000112	P19235	EPOR_HUMAN	erythropoietin receptor precursor	475	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CCCTTGGGCTCCCTGGGAGTC	0.592											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	32	85										T	11488763	C	T	11488763	3	4	92	1	0	0	0	0	1	0	0	0	5189	855	30	1	106	1	EPOR	19	11488763	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1093198	11488763	47640220	189	27689										
C19orf44	84167	broad.mit.edu	37	chr19	16614092	16614092	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccttttcaaactcagtgtctTtaaagatggggcatgtcaag	9	8	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:16614092T>G	uc002neh.1	+	3	1049	c.976T>G	c.(976-978)TTA>GTA	p.L326V	MED26_uc002nee.2_Intron|C19orf44_uc002nef.1_Missense_Mutation_p.L326V|C19orf44_uc002neg.2_Missense_Mutation_p.L326V|C19orf44_uc010eai.1_RNA	NM_032207	NP_115583	Q9H6X5	CS044_HUMAN	hypothetical protein LOC84167	326											0						CTCAGTGTCTTTAAAGATGGG	0.562													0	0	0	0.010504	0	21	54										G	16614092	T	G	16614092	3	3	92	1	0	0	0	0	1	0	0	0	1927	1838	64	5	982	5	C19orf44	19	16614092	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	5125329	16614092	42514891	190	27690										
PLVAP	83483	broad.mit.edu	37	chr19	17476312	17476312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccttctccaccttctgtttcGcctcctgactggcccgcagg	8	18	2	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:17476312G>A	uc002ngk.1	-	3	1012	c.962C>T	c.(961-963)GCG>GTG	p.A321V		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTTCTGTTTCGCCTCCTGACT	0.667													0	0	0	0.009096	0	4	33										A	17476312	G	A	17476312	3	1	92	1	0	0	0	0	1	0	0	0	12116	1087	38	2	382	2	PLVAP	19	17476312	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	862220	17476312	41652671	191	27691										
ZNF208	7757	broad.mit.edu	37	chr19	22154750	22154750	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tgtcacattcttcacatttgTagggtgtctctccagtgtga	9	9	4	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:22154750T>C	uc002nqp.2	-	6	2851	c.2702A>G	c.(2701-2703)TAC>TGC	p.Y901C	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTCACATTTGTAGGGTGTCTC	0.418													0	0	0	0.01892	0	24	47										C	22154750	T	C	22154750	3	2	92	1	0	0	0	0	1	0	0	0	17763	1638	57	5	760	5	ZNF208	19	22154750	Missense_Mutation	SNP	T	TCGA-G2-A2EC-01A-11D-A17V-08	4678438	22154750	36974233	192	27692										
MAP4K1	11184	broad.mit.edu	37	chr19	39106878	39106878	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccagccccacagaattccatGcagatccagagtttctgcaa	7	14	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:39106878G>A	uc002oix.1	-	4	378	c.270C>T	c.(268-270)TGC>TGT	p.C90C	MAP4K1_uc002oiy.1_Silent_p.C90C|MAP4K1_uc010xug.1_5'Flank|EIF3K_uc010xuh.1_5'Flank|EIF3K_uc002oiz.1_5'Flank|EIF3K_uc010xui.1_5'Flank	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	90	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGAATTCCATGCAGATCCAGA	0.488													0	0	0	0.008291	0	10	24										A	39106878	G	A	39106878	2	1	92	1	0	0	0	0	0	0	0	1	9259	1311	46	2		2	MAP4K1	19	39106878	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	16952128	39106878	20022105	193	27693										
ZC3H4	23211	broad.mit.edu	37	chr19	47572355	47572355	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gggcggacacgtgccttcctCattctcccggtcctgcttgc	11	16	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:47572355C>T	uc002pga.3	-	14	2430	c.2392G>A	c.(2392-2394)GAG>AAG	p.E798K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	798	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GTGCCTTCCTCATTCTCCCGG	0.677													0	0	0	0.00623	0	38	95										T	47572355	C	T	47572355	3	4	92	1	0	0	0	0	1	0	0	0	17567	835	29	1	1527	1	ZC3H4	19	47572355	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	8465477	47572355	11556628	194	27694										
ZNF667	63934	broad.mit.edu	37	chr19	56953098	56953098	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	tttgcagttccagaaaacatCttcccacattccttacactc	3	14	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:56953098C>T	uc002qnd.2	-	5	1428	c.1266G>A	c.(1264-1266)AAG>AAA	p.K422K	ZNF667_uc010etl.2_Silent_p.K204K|ZNF667_uc002qne.2_Silent_p.K422K|ZNF667_uc010etm.2_Silent_p.K365K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	422	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		CAGAAAACATCTTCCCACATT	0.343													0	0	0	0.006214	0	10	19										T	56953098	C	T	56953098	2	4	92	1	0	0	0	0	0	0	0	1	18071	912	32	1		1	ZNF667	19	56953098	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	9380743	56953098	2175885	195	27695										
ZSCAN1	284312	broad.mit.edu	37	chr19	58564970	58564970	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggaacactgaccagagcggcCgccaccagccatccctcaag	10	17	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr19:58564970C>T	uc002qrc.1	+	6	1025	c.778C>T	c.(778-780)CGC>TGC	p.R260C		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	260					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCAGAGCGGCCGCCACCAGCC	0.627													0	0	0	0.001168	0	6	39										T	58564970	C	T	58564970	3	4	92	1	0	0	0	0	1	0	0	0	18223	652	23	2	792	2	ZSCAN1	19	58564970	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	1611872	58564970	564013	196	27696										
UBOX5	22888	broad.mit.edu	37	chr20	3102035	3102035	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aggatgctgaattacctgtcGagcagtccatatgtgtcagg	12	8	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:3102035G>A	uc002whw.2	-	3	1420	c.1250C>T	c.(1249-1251)TCG>TTG	p.S417L	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.S417L|UBOX5_uc002why.1_Missense_Mutation_p.S417L	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	417						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						ATTACCTGTCGAGCAGTCCAT	0.527													0	0	0	0.001168	0	6	43										A	3102035	G	A	3102035	3	1	92	1	0	0	0	0	1	0	0	0	16891	1059	37	1	387	1	UBOX5	20	3102035	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		3102035	59923485	197	27697										
POFUT1	23509	broad.mit.edu	37	chr20	30804435	30804435	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggaaacccctttggcccattCtgggatcagtttcatgtgag	11	10	3	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:30804435C>T	uc002wxp.2	+	4	502	c.453C>T	c.(451-453)TTC>TTT	p.F151F	POFUT1_uc002wxo.2_Silent_p.F151F|POFUT1_uc010ztt.1_Silent_p.F43F|POFUT1_uc010ztu.1_Intron	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	151					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGGCCCATTCTGGGATCAGT	0.507													0	0	0	0.010504	0	18	71										T	30804435	C	T	30804435	2	4	92	1	0	0	0	0	0	0	0	1	12183	912	32	1		1	POFUT1	20	30804435	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	27702400	30804435	32221085	198	27698										
EMILIN3	90187	broad.mit.edu	37	chr20	39990047	39990047	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catggctccacaggccctctCtgggcctcagtggctcagtg	12	15	3	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:39990047C>A	uc002xjy.1	-	4	2386	c.2162G>T	c.(2161-2163)AGA>ATA	p.R721I		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	721						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CAGGCCCTCTCTGGGCCTCAG	0.672													1	0	4.3838e-07	0.016723	4.61085e-07	14	15										A	39990047	C	A	39990047	3	1	92	1	0	0	0	0	1	0	0	0	5095	913	32	3	142	3	EMILIN3	20	39990047	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	9185612	39990047	23035473	199	27699										
PKIG	11142	broad.mit.edu	37	chr20	43246949	43246949	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gacaggtggagggaagcgccCcagacaaggaagctggcaac	16	10	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:43246949C>G	uc002xmg.2	+	6	704	c.175C>G	c.(175-177)CCA>GCA	p.P59A	PKIG_uc002xmh.2_Missense_Mutation_p.P59A|PKIG_uc002xmi.2_Missense_Mutation_p.P59A	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	59							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			GGGAAGCGCCCCAGACAAGGA	0.547													0	0	0	0.007291	0	29	152										G	43246949	C	G	43246949	3	3	92	1	0	0	0	0	1	0	0	0	11975	623	22	4	181	4	PKIG	20	43246949	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	3256902	43246949	19778571	200	27700										
SNX21	90203	broad.mit.edu	37	chr20	44469809	44469809	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ctttgctggcaccctttctgGaggcccatgtccggctctcc	10	16	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:44469809G>C	uc002xpv.1	+	4	1068	c.979G>C	c.(979-981)GAG>CAG	p.E327Q	SNX21_uc002xps.1_Intron|SNX21_uc002xpt.1_3'UTR|SNX21_uc002xpu.1_3'UTR|SNX21_uc002xpw.1_Missense_Mutation_p.E138Q|SNX21_uc002xpx.2_Missense_Mutation_p.E317Q|SNX21_uc010zxd.1_3'UTR|SNX21_uc002xpy.1_Missense_Mutation_p.E138Q|SNX21_uc002xpz.1_Missense_Mutation_p.E138Q	NM_033421	NP_219489	Q969T3	SNX21_HUMAN	sorting nexin 21 isoform a	327					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			breast(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				ACCCTTTCTGGAGGCCCATGT	0.657													0	0	0	0.010818	0	32	46										C	44469809	G	C	44469809	3	2	92	1	0	0	0	0	1	0	0	0	14893	1175	41	1	1008	1	SNX21	20	44469809	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	1222860	44469809	18555711	201	27701										
SPATA2	9825	broad.mit.edu	37	chr20	48522407	48522407	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cgggaggcggtcgaggccctGagtctggcctgggtacttct	17	11	2	1	rs145093250		TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:48522407G>A	uc010gie.2	-	3	1662	c.1312C>T	c.(1312-1314)CAG>TAG	p.Q438*	SPATA2_uc002xuw.2_Nonsense_Mutation_p.Q438*|SPATA2_uc010zyn.1_Nonsense_Mutation_p.Q301*	NM_001135773	NP_001129245	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	438					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCGAGGCCCTGAGTCTGGCCT	0.662													0	0	0	0.016723	0	14	52										A	48522407	G	A	48522407	4	1	92	1	0	0	0	0	0	1	0	0	15004	1299	45	1	254	1	SPATA2	20	48522407	Nonsense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	4052598	48522407	14503113	202	27702										
DIDO1	11083	broad.mit.edu	37	chr20	61511415	61511415	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cctctggtcttcgaactgctGaggctgaatgcccctgggac	12	13	2	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61511415G>A	uc002ydr.1	-	16	6157	c.5893C>T	c.(5893-5895)CAG>TAG	p.Q1965*	DIDO1_uc002yds.1_Nonsense_Mutation_p.Q1965*	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1965	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCGAACTGCTGAGGCTGAATG	0.577													0	0	0	0.01441	0	46	198										A	61511415	G	A	61511415	4	1	92	1	0	0	0	0	0	1	0	0	4522	1299	45	1	833	1	DIDO1	20	61511415	Nonsense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	12989008	61511415	1514105	203	27703			2	123		4	4	1564	G		1.995306e-07
DIDO1	11083	broad.mit.edu	37	chr20	61511882	61511882	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	catgttgccccgagaataagGaagggatgggccccttctgg	14	10	1	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61511882G>T	uc002ydr.1	-	16	5690	c.5426C>A	c.(5425-5427)TCC>TAC	p.S1809Y	DIDO1_uc002yds.1_Missense_Mutation_p.S1809Y	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1809	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGAGAATAAGGAAGGGATGGG	0.607													1	0	1.22574e-08	0.014323	1.31543e-08	20	97										T	61511882	G	T	61511882	3	4	92	1	0	0	0	0	1	0	0	0	4522	1174	41	3	1300	3	DIDO1	20	61511882	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	467	61511882	1513638	204	27704			2	123		4	4	1564	G		1.995306e-07
DIDO1	11083	broad.mit.edu	37	chr20	61512446	61512446	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccgctgggggcttttcgcccGaagcccagggggaagaggct	17	12	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61512446G>A	uc002ydr.1	-	16	5126	c.4862C>T	c.(4861-4863)TCG>TTG	p.S1621L	DIDO1_uc002yds.1_Missense_Mutation_p.S1621L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1621					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTTTCGCCCGAAGCCCAGGG	0.711													0	0	0	0.001984	0	7	8										A	61512446	G	A	61512446	3	1	92	1	0	0	0	0	1	0	0	0	4522	1059	37	1	1864	1	DIDO1	20	61512446	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	564	61512446	1513074	205	27705			2	123		4	4	1564	G		1.995306e-07
DIDO1	11083	broad.mit.edu	37	chr20	61512978	61512978	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggcacacatcctgttgggcaGgtcatcaacagtcactttcg	10	12	3	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr20:61512978G>A	uc002ydr.1	-	16	4594	c.4330C>T	c.(4330-4332)CTG>TTG	p.L1444L	DIDO1_uc002yds.1_Silent_p.L1444L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1444					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTGTTGGGCAGGTCATCAACA	0.617													0	0	0	0.009535	0	30	109										A	61512978	G	A	61512978	2	1	92	1	0	0	0	0	0	0	0	1	4522	991	35	2		2	DIDO1	20	61512978	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	532	61512978	1512542	206	27706			2	123		4	4	1564	G		1.995306e-07
DEPDC5	9681	broad.mit.edu	37	chr22	32174116	32174116	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gtgaactgtgggttaagaatGagaaggtcatgtgtggctac	15	4	1	3			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr22:32174116G>A	uc003als.2	+	8	587	c.445G>A	c.(445-447)GAG>AAG	p.E149K	DEPDC5_uc011als.1_Missense_Mutation_p.E149K|DEPDC5_uc011alu.1_Missense_Mutation_p.E149K|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.E149K|DEPDC5_uc003alr.1_Missense_Mutation_p.E149K|DEPDC5_uc011alt.1_Missense_Mutation_p.E121K	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	149					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GGTTAAGAATGAGAAGGTCAT	0.333													0	0	0	0.010818	0	30	65										A	32174116	G	A	32174116	3	1	92	1	0	0	0	0	1	0	0	0	4442	1291	45	1	471	1	DEPDC5	22	32174116	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		32174116	19130450	207	27707										
MGAT3	4248	broad.mit.edu	37	chr22	39883792	39883792	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	caacggctcctcggcccggcGgccaccccggtacctcctga	11	20	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chr22:39883792G>A	uc003axv.3	+	2	679	c.440G>A	c.(439-441)CGG>CAG	p.R147Q	MGAT3_uc010gxy.2_Missense_Mutation_p.R147Q	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	147	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					TCGGCCCGGCGGCCACCCCGG	0.766													0	0	0	0.004672	0	3	0										A	39883792	G	A	39883792	3	1	92	1	0	0	0	0	1	0	0	0	9544	1116	39	2	442	2	MGAT3	22	39883792	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	7709676	39883792	11420774	208	27708										
PTCHD1	139411	broad.mit.edu	37	chrX	23398359	23398359	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ccttcctgggagtccctttcGtcatgctaggtaattactac	8	12	1	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:23398359G>A	uc004dal.3	+	2	1011	c.1003G>A	c.(1003-1005)GTC>ATC	p.V335I	PTCHD1_uc010nfu.1_Missense_Mutation_p.V335I	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	335	Helical; (Potential).|SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						AGTCCCTTTCGTCATGCTAGG	0.483													0	0	0	0.013537	0	10	83										A	23398359	G	A	23398359	3	1	92	1	0	0	0	0	1	0	0	0	12732	1145	40	2	1009	2	PTCHD1	23	23398359	Missense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08		23398359	131872201	209	27709										
RBM10	8241	broad.mit.edu	37	chrX	47044531	47044531	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	aaaaatagcttccagcctatCagctccctgcgagatgacga	8	12	1	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:47044531C>A	uc004dhf.2	+	18	2407	c.2028C>A	c.(2026-2028)ATC>ATA	p.I676I	RBM10_uc004dhg.2_Silent_p.I598I|RBM10_uc004dhh.2_Silent_p.I675I|RBM10_uc010nhq.2_Silent_p.I599I|RBM10_uc004dhi.2_Silent_p.I741I	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	676					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						TCCAGCCTATCAGCTCCCTGC	0.567													1	0	3.27435e-08	0.020292	3.49971e-08	13	26										A	47044531	C	A	47044531	2	1	92	1	0	0	0	0	0	0	0	1	13111	816	29	3		3	RBM10	23	47044531	Silent	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	23646172	47044531	108226029	210	27710										
CFP	5199	broad.mit.edu	37	chrX	47485822	47485822	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	ggcccctgcaggtcctcccgCgtgactgctggcccgggatt	14	16	0	1			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:47485822C>T	uc004dig.3	-	7	1163	c.1037G>A	c.(1036-1038)CGC>CAC	p.R346H	CFP_uc004dih.2_Missense_Mutation_p.R346H|CFP_uc004dii.1_Missense_Mutation_p.R282H|CFP_uc010nhu.2_Missense_Mutation_p.R346H	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	346	TSP type-1 5.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3						GGTCCTCCCGCGTGACTGCTG	0.622													0	0	0	0.020292	0	12	23										T	47485822	C	T	47485822	3	4	92	1	0	0	0	0	1	0	0	0	3293	768	27	2	384	2	CFP	23	47485822	Missense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	441291	47485822	107784738	211	27711										
SMC1A	8243	broad.mit.edu	37	chrX	53436094	53436094	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	gcgggcatcccctagctgctCcatcacctggttcagctcct	9	17	2	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:53436094C>A	uc004dsg.2	-	9	1513	c.1444G>T	c.(1444-1446)GAG>TAG	p.E482*	SMC1A_uc011moe.1_Nonsense_Mutation_p.E460*|SMC1A_uc011mof.1_Nonsense_Mutation_p.E248*	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	482	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						CCTAGCTGCTCCATCACCTGG	0.562													1	0	2.27111e-07	0.013537	2.40792e-07	13	37										A	53436094	C	A	53436094	4	1	92	1	0	0	0	0	0	1	0	0	14781	864	30	3	2325	3	SMC1A	23	53436094	Nonsense_Mutation	SNP	C	TCGA-G2-A2EC-01A-11D-A17V-08	5950272	53436094	101834466	212	27712										
PHF8	23133	broad.mit.edu	37	chrX	54022189	54022189	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	acggttcgcactgtctccggGatctcatcctcatggtctgg	11	13	4	0			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:54022189G>A	uc004dsu.2	-	12	1441	c.1368C>T	c.(1366-1368)ATC>ATT	p.I456I	PHF8_uc004dst.2_Silent_p.I420I|PHF8_uc004dsv.2_Silent_p.I286I|PHF8_uc004dsw.2_Silent_p.I420I|PHF8_uc004dsx.2_Silent_p.I184I|PHF8_uc004dsy.2_Silent_p.I420I	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	456					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						CTGTCTCCGGGATCTCATCCT	0.393													0	0	0	0.001984	0	7	20										A	54022189	G	A	54022189	2	1	92	1	0	0	0	0	0	0	0	1	11840	1164	41	1		1	PHF8	23	54022189	Silent	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	586095	54022189	101248371	213	27713										
ZMYM3	9203	broad.mit.edu	37	chrX	70470474	70470474	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.388625592417062	82	2.23826589548687e-28	3.80966654177595	4.73477812177503	3.28235294117647	0.290150832083051	0.483584720138418	60	cggccctttgtgacacacttGagcgtagggacatgcgagga	14	10	0	2			TCGA-G2-A2EC-01A-11D-A17V-08	TCGA-G2-A2EC-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1376c881-cea5-4470-8dc1-63c69f201570	f76ab1a8-ac91-4fd9-9fd1-219ead6195ce	g.chrX:70470474G>C	uc004dzh.1	-	5	968	c.881C>G	c.(880-882)TCA>TGA	p.S294*	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Nonsense_Mutation_p.S294*|ZMYM3_uc004dzj.1_Nonsense_Mutation_p.S294*|ZMYM3_uc011mpu.1_Nonsense_Mutation_p.S25*|ZMYM3_uc004dzk.3_Nonsense_Mutation_p.S294*|ZMYM3_uc004dzl.3_Nonsense_Mutation_p.S294*|ZMYM3_uc004dzm.3_Nonsense_Mutation_p.S294*	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	294					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TGACACACTTGAGCGTAGGGA	0.587													0	0	0	0.014758	0	5	15										C	70470474	G	C	70470474	4	2	92	1	0	0	0	0	0	1	0	0	17698	1294	45	1	3333	1	ZMYM3	23	70470474	Nonsense_Mutation	SNP	G	TCGA-G2-A2EC-01A-11D-A17V-08	16448285	70470474	84800086	214	27714										
NOC2L	26155	broad.mit.edu	37	chr1	892328	892328	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acggtcacaggaacagaattCttcttccccttcagccctct	6	15	5	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:892328C>G	uc001abz.3	-	4	491	c.432G>C	c.(430-432)AAG>AAC	p.K144N	NOC2L_uc001aby.3_5'UTR|NOC2L_uc009vjq.2_Missense_Mutation_p.K144N	NM_015658	NP_056473	Q9Y3T9	NOC2L_HUMAN	nucleolar complex associated 2 homolog	144						nucleolus	protein binding			ovary(1)|skin(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.86e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.08e-23)|Colorectal(212;0.000161)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(365;0.000475)|Kidney(185;0.00231)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		GAACAGAATTCTTCTTCCCCT	0.592													0	0	0	0.01441	0	72	124										G	892328	C	G	892328	3	3	93	1	0	0	0	0	1	0	0	0	10513	912	32	1	1881	1	NOC2L	1	892328	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		892328	248358293	1	27715										
PLEKHN1	84069	broad.mit.edu	37	chr1	906303	906303	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgctctgccccagccgggccGagctggaccgctggctttac	13	16	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:906303G>C	uc001ace.2	+	5	684	c.649G>C	c.(649-651)GAG>CAG	p.E217Q	PLEKHN1_uc001acd.2_Missense_Mutation_p.E177Q|PLEKHN1_uc001acf.2_Missense_Mutation_p.E177Q	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	217	PH 1.										0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CAGCCGGGCCGAGCTGGACCG	0.726													0	0	0	0.006122	0	17	11										C	906303	G	C	906303	3	2	93	1	0	0	0	0	1	0	0	0	12083	1059	37	1	551	1	PLEKHN1	1	906303	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	13975	906303	248344318	2	27716										
TTLL10	254173	broad.mit.edu	37	chr1	1117193	1117193	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccaggatacctcaggccacaGaggtagactcagcccagctg	11	14	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:1117193G>T	uc001acy.2	+	9	979	c.828G>T	c.(826-828)CAG>CAT	p.Q276H	uc001acx.1_5'Flank|TTLL10_uc010nyg.1_Missense_Mutation_p.Q276H|TTLL10_uc001acz.1_Missense_Mutation_p.Q203H	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	276	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCAGGCCACAGAGGTAGACTC	0.637													1	0	2.52707e-12	0.006214	2.69921e-12	10	13										T	1117193	G	T	1117193	3	4	93	1	0	0	0	0	1	0	0	0	16720	933	33	3	850	3	TTLL10	1	1117193	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	210890	1117193	248133428	3	27717										
CELA2B	51032	broad.mit.edu	37	chr1	15809801	15809801	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctggctaaccccgtctccctCaccgacaagatccagctggc	8	18	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:15809801C>T	uc001awl.2	+	5	424	c.399C>T	c.(397-399)CTC>CTT	p.L133L		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	133	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						CCGTCTCCCTCACCGACAAGA	0.602													0	0	0	0.004878	0	32	42										T	15809801	C	T	15809801	2	4	93	1	0	0	0	0	0	0	0	1	3212	813	29	1		1	CELA2B	1	15809801	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	14692608	15809801	233440820	4	27718										
CASP9	842	broad.mit.edu	37	chr1	15821948	15821948	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aaacccatggtctttctgctCtgcaggaagcagaaacaaac	8	11	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:15821948C>G	uc001awn.2	-	7	964	c.869_splice	c.e7-1	p.E290_splice	CASP9_uc001awm.1_Splice_Site_p.E290_splice|CASP9_uc001awo.2_Splice_Site_p.E140_splice|CASP9_uc001awp.2_Splice_Site_p.E134_splice|CASP9_uc009voi.2_Splice_Site_p.E134_splice|CASP9_uc010obm.1_Splice_Site_p.E207_splice|CASP9_uc001awq.2_Splice_Site_p.E207_splice	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein						activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		TCTTTCTGCTCTGCAGGAAGC	0.388													0	0	0	0.001168	0	5	14										G	15821948	C	G	15821948	5	3	93	1	0	0	0	0	0	0	1	0	2679	927	32	1	394	1	CASP9	1	15821948	Splice_Site	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	12147	15821948	233428673	5	27719										
SPEN	23013	broad.mit.edu	37	chr1	16258553	16258553	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gattggagcgagagcttcagGaggctgcagcggttcccacc	15	11	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:16258553G>A	uc001axk.1	+	11	6022	c.5818G>A	c.(5818-5820)GAG>AAG	p.E1940K	SPEN_uc010obp.1_Missense_Mutation_p.E1899K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1940	Potential.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGAGCTTCAGGAGGCTGCAGC	0.587													0	0	0	0.010504	0	18	73										A	16258553	G	A	16258553	3	1	93	1	0	0	0	0	1	0	0	0	15037	1175	41	1	5860	1	SPEN	1	16258553	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	436605	16258553	232992068	6	27720										
NBPF1	55672	broad.mit.edu	37	chr1	16891403	16891403	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cttttcttccccttccccttCttttcaatttctgcaataaa	1	14	4	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:16891403C>G	uc009vos.1	-	29	4188	c.3300G>C	c.(3298-3300)AAG>AAC	p.K1100N	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1100	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ccttccccttcttTTCAATTT	0.259													0	0	0	0.00245	0	5	600										G	16891403	C	G	16891403	3	3	93	1	0	0	0	0	1	0	0	0	10192	912	32	1	352	1	NBPF1	1	16891403	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	632850	16891403	232359218	7	27721										
EIF4G3	8672	broad.mit.edu	37	chr1	21268770	21268770	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cttctctccactgaggactaGcctaaggactggggaaggag	13	10	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:21268770G>A	uc001bec.2	-	9	965	c.709C>T	c.(709-711)CTA>TTA	p.L237L	EIF4G3_uc010odi.1_5'UTR|EIF4G3_uc010odj.1_Silent_p.L236L|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Silent_p.L237L|EIF4G3_uc001bef.2_Silent_p.L236L|EIF4G3_uc001bee.2_Silent_p.L243L|EIF4G3_uc001beg.2_Silent_p.L236L|EIF4G3_uc010odk.1_Silent_p.L237L|EIF4G3_uc001beh.2_Silent_p.L248L	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	237					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTGAGGACTAGCCTAAGGACT	0.438													0	0	0	0.00632	0	27	108										A	21268770	G	A	21268770	2	1	93	1	0	0	0	0	0	0	0	1	5038	962	34	2		2	EIF4G3	1	21268770	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4377367	21268770	227981851	8	27722										
HSPG2	3339	broad.mit.edu	37	chr1	22178283	22178283	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagcctggtggccccactcaCggtaggctaagttggccccc	12	16	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:22178283C>T	uc001bfj.2	-	54	7046	c.7006_splice	c.e54+1	p.P2336_splice	HSPG2_uc009vqd.2_Splice_Site_p.P2337_splice	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor						angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCCCACTCACGGTAGGCTAA	0.637													0	0	0	0.003755	0	33	39										T	22178283	C	T	22178283	5	4	93	1	0	0	0	0	0	0	1	0	7430	550	19	2	6344	2	HSPG2	1	22178283	Splice_Site	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	909513	22178283	227072338	9	27723										
C1QB	713	broad.mit.edu	37	chr1	22987517	22987517	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	caagaaccatcaacgtccccCtgcgccgggaccagaccatc	8	18	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:22987517C>T	uc001bgd.2	+	3	532	c.400C>T	c.(400-402)CTG>TTG	p.L134L		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	134	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAACGTCCCCCTGCGCCGGGA	0.602													0	0	0	0.014323	0	23	84										T	22987517	C	T	22987517	2	4	93	1	0	0	0	0	0	0	0	1	1955	680	24	2		2	C1QB	1	22987517	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	809234	22987517	226263104	10	27724										
YTHDF2	51441	broad.mit.edu	37	chr1	29069930	29069930	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tggttctggatctactccttCagaaccccacccagtgttgg	9	13	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:29069930C>T	uc001brc.2	+	4	1645	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	YTHDF2_uc001brd.2_Missense_Mutation_p.S380L|YTHDF2_uc010ofx.1_Missense_Mutation_p.S333L|YTHDF2_uc001bre.2_Missense_Mutation_p.S333L	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	383					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		TCTACTCCTTCAGAACCCCAC	0.498													0	0	0	0.012319	0	22	73										T	29069930	C	T	29069930	3	4	93	1	0	0	0	0	1	0	0	0	17496	838	29	1	1162	1	YTHDF2	1	29069930	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6082413	29069930	220180691	11	27725										
BAI2	576	broad.mit.edu	37	chr1	32205546	32205546	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctagattatctgtgacaatCagagagctctggaaggcctt	10	9	3	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:32205546C>T	uc001btn.2	-	14	2502	c.2148G>A	c.(2146-2148)CTG>CTA	p.L716L	BAI2_uc010ogo.1_Silent_p.L358L|BAI2_uc010ogp.1_Silent_p.L649L|BAI2_uc010ogq.1_Silent_p.L716L|BAI2_uc001bto.2_Silent_p.L716L|BAI2_uc001btq.1_Silent_p.L649L|BAI2_uc010ogr.1_Missense_Mutation_p.D526N	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	716	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CTGTGACAATCAGAGAGCTCT	0.552													0	0	0	0.010729	0	11	48										T	32205546	C	T	32205546	2	4	93	1	0	0	0	0	0	0	0	1	1299	813	29	1		1	BAI2	1	32205546	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3135616	32205546	217045075	12	27726										
SYNC	81493	broad.mit.edu	37	chr1	33149906	33149906	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctgagccttagctgttccatCtctttgttcttctgttgctg	8	11	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33149906C>G	uc001bvt.2	-	3	1411	c.1311G>C	c.(1309-1311)GAG>GAC	p.E437D	SYNC_uc010ohl.1_Missense_Mutation_p.E437D|RBBP4_uc001bvr.2_3'UTR|RBBP4_uc001bvs.2_3'UTR|RBBP4_uc010ohj.1_3'UTR|RBBP4_uc010ohk.1_3'UTR	NM_030786	NP_110413	Q9H7C4	SYNCI_HUMAN	syncoilin, intermediate filament 1 isoform 1	437	Coil 2.					intermediate filament|perinuclear region of cytoplasm	structural molecule activity			ovary(1)	1						GCTGTTCCATCTCTTTGTTCT	0.463													0	0	0	0.01441	0	59	152										G	33149906	C	G	33149906	3	3	93	1	0	0	0	0	1	0	0	0	15440	912	32	1	211	1	SYNC	1	33149906	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	944360	33149906	216100715	13	27727										
SYNC	81493	broad.mit.edu	37	chr1	33149943	33149943	+	Frame_Shift_Del	DEL	C	C	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctggagttgcaccccatttCttaactgcctctggcgttct							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33149943delC	uc001bvt.2	-	3	1374	c.1274delG	c.(1273-1275)AGAfs	p.R425fs	SYNC_uc010ohl.1_Frame_Shift_Del_p.R425fs|RBBP4_uc001bvr.2_3'UTR|RBBP4_uc001bvs.2_3'UTR|RBBP4_uc010ohj.1_3'UTR|RBBP4_uc010ohk.1_3'UTR	NM_030786	NP_110413	Q9H7C4	SYNCI_HUMAN	syncoilin, intermediate filament 1 isoform 1	425	Coil 2.					intermediate filament|perinuclear region of cytoplasm	structural molecule activity			ovary(1)	1						CACCCCATTTCTTAACTGCCT	0.443																		33	112	---	---								-	33149943	C	-	33149943	7	5	93	1	0	1	0	1	0	0	0	0	15440	913	32	0	248	0	SYNC	1	33149943	Frame_Shift_Del	DEL	C	TCGA-G2-A2EF-01A-12D-A18F-08	37	33149943	216100678	14	27728										
KIAA1522	57648	broad.mit.edu	37	chr1	33236757	33236757	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cccctgggtgacaggtttgtCatacctcctcaccccaaggt	9	15	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33236757C>T	uc001bvv.2	+	6	1936	c.1800C>T	c.(1798-1800)GTC>GTT	p.V600V	KIAA1522_uc001bvu.1_Silent_p.V659V|KIAA1522_uc010ohm.1_Silent_p.V611V|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	600	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACAGGTTTGTCATACCTCCTC	0.632													0	0	0	0.01441	0	68	77										T	33236757	C	T	33236757	2	4	93	1	0	0	0	0	0	0	0	1	8238	813	29	1		1	KIAA1522	1	33236757	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	86814	33236757	216013864	15	27729										
CSMD2	114784	broad.mit.edu	37	chr1	33992844	33992844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggcagtgttgatgggtctccCactgggccggacctctgctg	15	12	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:33992844C>T	uc001bxn.1	-	64	9783	c.9754G>A	c.(9754-9756)GGG>AGG	p.G3252R	CSMD2_uc001bxm.1_Missense_Mutation_p.G3396R	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3252	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATGGGTCTCCCACTGGGCCGG	0.502													0	0	0	0.004482	0	7	61										T	33992844	C	T	33992844	3	4	93	1	0	0	0	0	1	0	0	0	3945	594	21	2	733	2	CSMD2	1	33992844	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	756087	33992844	215257777	16	27730										
CAP1	10487	broad.mit.edu	37	chr1	40537148	40537148	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttcccagttcctgagcagttCaagaccctatggaacgggca	10	12	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:40537148C>G	uc001cfa.3	+	13	1600	c.1371C>G	c.(1369-1371)TTC>TTG	p.F457L	CAP1_uc001cey.3_Missense_Mutation_p.F457L|CAP1_uc001cez.3_Missense_Mutation_p.F457L|CAP1_uc009vvz.2_Missense_Mutation_p.F457L|CAP1_uc010oje.1_Missense_Mutation_p.F374L	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	457					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGAGCAGTTCAAGACCCTAT	0.473													0	0	0	0.007413	0	18	11										G	40537148	C	G	40537148	3	3	93	1	0	0	0	0	1	0	0	0	2619	825	29	1	1417	1	CAP1	1	40537148	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6544304	40537148	208713473	17	27731										
C1orf175	374977	broad.mit.edu	37	chr1	55118945	55118945	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccaaggatgtctcaaggcctGactcacaggggcgcctctgt	12	13	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:55118945G>A	uc010ooe.1	+	3	670	c.346G>A	c.(346-348)GAC>AAC	p.D116N	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxo.2_Missense_Mutation_p.D116N|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Intron|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.D116N|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	116						integral to membrane	binding				0						CTCAAGGCCTGACTCACAGGG	0.403													0	0	0	0.01441	0	72	81										A	55118945	G	A	55118945	3	1	93	1	0	0	0	0	1	0	0	0	2016	1290	45	1	348	1	C1orf175	1	55118945	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	14581797	55118945	194131676	18	27732										
PRKAA2	5563	broad.mit.edu	37	chr1	57171852	57171852	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcttacaactttacctggttGataacaggagctatcttttg	8	8	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:57171852G>A	uc001cyk.3	+	8	1452	c.1381G>A	c.(1381-1383)GAT>AAT	p.D461N		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	461					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding	p.D461N(1)		breast(4)|ovary(1)|stomach(1)	6						TTACCTGGTTGATAACAGGAG	0.378													0	0	0	0.009535	0	30	38										A	57171852	G	A	57171852	3	1	93	1	0	0	0	0	1	0	0	0	12494	1290	45	1	1411	1	PRKAA2	1	57171852	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2052907	57171852	192078769	19	27733										
PKN2	5586	broad.mit.edu	37	chr1	89236127	89236127	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagattcttcaggcagtccaGactaatgaattggcttttga	9	8	2	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:89236127G>T	uc001dmn.2	+	4	939	c.597G>T	c.(595-597)CAG>CAT	p.Q199H	PKN2_uc001dmm.1_Missense_Mutation_p.Q199H|PKN2_uc010osp.1_Missense_Mutation_p.Q199H|PKN2_uc010osq.1_Missense_Mutation_p.Q42H|PKN2_uc009wcv.2_Missense_Mutation_p.Q199H	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	199	REM 2.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		AGGCAGTCCAGACTAATGAAT	0.408													1	0	7.01153e-11	0.007291	7.40841e-11	27	38										T	89236127	G	T	89236127	3	4	93	1	0	0	0	0	1	0	0	0	11980	933	33	3	611	3	PKN2	1	89236127	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	32064275	89236127	160014494	20	27734										
AGL	178	broad.mit.edu	37	chr1	100387187	100387187	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtcaattgctactattcttGagacactttatgatttatag	7	6	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:100387187G>C	uc001dsi.1	+	34	4979	c.4579G>C	c.(4579-4581)GAG>CAG	p.E1527Q	AGL_uc001dsj.1_Missense_Mutation_p.E1527Q|AGL_uc001dsk.1_Missense_Mutation_p.E1527Q|AGL_uc001dsl.1_Missense_Mutation_p.E1527Q|AGL_uc001dsm.1_Missense_Mutation_p.E1511Q|AGL_uc001dsn.1_Missense_Mutation_p.E1510Q	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1527	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TACTATTCTTGAGACACTTTA	0.378													0	0	0	0.006214	0	9	42										C	100387187	G	C	100387187	3	2	93	1	0	0	0	0	1	0	0	0	384	1291	45	1	4778	1	AGL	1	100387187	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	11151060	100387187	148863434	21	27735										
NRAS	4893	broad.mit.edu	37	chr1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcatggcactgtactcttctTgtccagctgtatccagtatg	8	11	3	0	rs11554290		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:115256529T>C	uc009wgu.2	-	3	436	c.182A>G	c.(181-183)CAA>CGA	p.Q61R		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458	Q61L(HEPG2_LIVER)|Q61R(SKMEL2_SKIN)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MHHES1_BONE)|Q61R(HT1197_URINARY_TRACT)|Q61L(MELJUSO_SKIN)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(KU1919_URINARY_TRACT)|Q61L(C3A_LIVER)|Q61R(TT2609C02_THYROID)|Q61R(NCIH2347_LUNG)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(SW1271_LUNG)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			0	0	0	0.013726	0	34	137										C	115256529	T	C	115256529	3	2	93	1	0	0	0	0	1	0	0	0	10640	1812	63	5	399	5	NRAS	1	115256529	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	14869342	115256529	133994092	22	27736										
PDE4DIP	9659	broad.mit.edu	37	chr1	144874708	144874708	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	actgggagaagctttcttctCttcatagtgtgtgtactcgc	10	9	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:144874708C>G	uc001elw.3	-	30	5191	c.4900G>C	c.(4900-4902)GAG>CAG	p.E1634Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E1590Q|PDE4DIP_uc001elv.3_Missense_Mutation_p.E641Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1634	NBPF.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTTTCTTCTCTTCATAGTGT	0.517			T	PDGFRB	MPD								0	0	0	0.005524	0	36	314										G	144874708	C	G	144874708	3	3	93	1	0	0	0	0	1	0	0	0	11643	922	32	1	2200	1	PDE4DIP	1	144874708	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	29618179	144874708	104375913	23	27737										
NOTCH2NL	388677	broad.mit.edu	37	chr1	145282020	145282020	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tctggaatggaaaagaacacGatgagaattagacactggaa	11	5	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:145282020G>A	uc001emn.3	+	5	1070	c.700G>A	c.(700-702)GAT>AAT	p.D234N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NOTCH2NL_uc001emm.3_Missense_Mutation_p.D234N|NOTCH2NL_uc001emo.2_Intron|NOTCH2NL_uc010oyh.1_Intron	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	234					cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						AAAAGAACACGATGAGAATTA	0.378													0	0	0	0.010729	0	10	71										A	145282020	G	A	145282020	3	1	93	1	0	0	0	0	1	0	0	0	10549	1058	37	1	714	1	NOTCH2NL	1	145282020	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	407312	145282020	103968601	24	27738										
NBPF10	100132406	broad.mit.edu	37	chr1	145367724	145367724	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tttattgcagaaattgaaaaGaaggggaaggggaaaaaaag	13	1	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:145367724G>C	uc001end.3	+	85	10580	c.10545G>C	c.(10543-10545)AAG>AAC	p.K3515N	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3440											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AAATTGAAaagaaggggaagg	0.259													0	0	0	0.00499	0	14	125										C	145367724	G	C	145367724	3	2	93	1	0	0	0	0	1	0	0	0	10193	933	33	1	10650	1	NBPF10	1	145367724	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	85704	145367724	103882897	25	27739										
GOLPH3L	55204	broad.mit.edu	37	chr1	150620960	150620960	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agacattctctagcacatcaGaggagtgggctagcaccagg	12	10	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:150620960G>C	uc001evj.2	-	5	912	c.695C>G	c.(694-696)TCT>TGT	p.S232C	GOLPH3L_uc010pci.1_Missense_Mutation_p.S188C	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	232						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TAGCACATCAGAGGAGTGGGC	0.473													0	0	0	0.003954	0	23	77										C	150620960	G	C	150620960	3	2	93	1	0	0	0	0	1	0	0	0	6569	942	33	1	166	1	GOLPH3L	1	150620960	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5253236	150620960	98629661	26	27740										
GOLPH3L	55204	broad.mit.edu	37	chr1	150621093	150621093	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgttgtattggtcactggatGagtagtcatgtcaaatagca	11	5	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:150621093G>T	uc001evj.2	-	5	779	c.562C>A	c.(562-564)CAT>AAT	p.H188N	GOLPH3L_uc010pci.1_Missense_Mutation_p.H144N	NM_018178	NP_060648	Q9H4A5	GLP3L_HUMAN	Golgi phosphoprotein 3-like	188						Golgi cisterna membrane				ovary(1)	1	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			GTCACTGGATGAGTAGTCATG	0.443													1	0	5.68852e-11	0.004482	6.02676e-11	9	39										T	150621093	G	T	150621093	3	4	93	1	0	0	0	0	1	0	0	0	6569	1290	45	3	299	3	GOLPH3L	1	150621093	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	133	150621093	98629528	27	27741										
LYSMD1	388695	broad.mit.edu	37	chr1	151137595	151137595	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctagtccagccagggtgtctCcgggctccaactgatgctcc	11	15	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:151137595C>T	uc001ewy.2	-	1	776	c.140G>A	c.(139-141)GGA>GAA	p.G47E	LYSMD1_uc010pcr.1_Intron|SCNM1_uc010pcs.1_5'Flank|SCNM1_uc001ewz.2_5'Flank|SCNM1_uc009wmn.2_5'Flank	NM_212551	NP_997716	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain	47	LysM.				cell wall macromolecule catabolic process						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGGGTGTCTCCGGGCTCCAA	0.562													0	0	0	0.004656	0	26	27										T	151137595	C	T	151137595	3	4	93	1	0	0	0	0	1	0	0	0	9124	855	30	1	555	1	LYSMD1	1	151137595	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	516502	151137595	98113026	28	27742										
FLG	2312	broad.mit.edu	37	chr1	152281835	152281835	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctgggacgtggtgtggctgtGatgagaccctgagtgtccag	17	8	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:152281835G>C	uc001ezu.1	-	3	5563	c.5527C>G	c.(5527-5529)CAC>GAC	p.H1843D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1843	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTGGCTGTGATGAGACCCT	0.532									Ichthyosis				0	0	0	0.01441	0	200	227										C	152281835	G	C	152281835	3	2	93	1	0	0	0	0	1	0	0	0	5922	1290	45	1	6662	1	FLG	1	152281835	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1144240	152281835	96968786	29	27743										
DENND4B	9909	broad.mit.edu	37	chr1	153902811	153902811	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tccaaaacattttcggcagtCaatggccttgggagtgggca	12	9	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:153902811C>T	uc001fdd.1	-	28	4854	c.4453G>A	c.(4453-4455)GAC>AAC	p.D1485N	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1485										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTTCGGCAGTCAATGGCCTTG	0.547													0	0	0	0.013537	0	12	34										T	153902811	C	T	153902811	3	4	93	1	0	0	0	0	1	0	0	0	4434	826	29	1	41	1	DENND4B	1	153902811	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1620976	153902811	95347810	30	27744										
KCNN3	3782	broad.mit.edu	37	chr1	154705586	154705586	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gatgagccacatggcacccaGaaagttactagttacgtcct	9	11	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:154705586G>A	uc001ffp.2	-	4	1797	c.1483C>T	c.(1483-1485)CTG>TTG	p.L495L	KCNN3_uc001ffo.2_Silent_p.L190L	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	500						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ATGGCACCCAGAAAGTTACTA	0.517													0	0	0	0.003163	0	15	53										A	154705586	G	A	154705586	2	1	93	1	0	0	0	0	0	0	0	1	8080	933	33	1		1	KCNN3	1	154705586	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	802775	154705586	94545035	31	27745										
HCN3	57657	broad.mit.edu	37	chr1	155257083	155257083	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttgaggagttccccatgatgCgccgggcctttgagactgtg	14	10	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:155257083C>T	uc001fjz.1	+	7	1605	c.1597C>T	c.(1597-1599)CGC>TGC	p.R533C	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Missense_Mutation_p.R228C	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	533	Cytoplasmic (Potential).|cAMP.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCCCATGATGCGCCGGGCCTT	0.617													0	0	0	0.012319	0	18	63										T	155257083	C	T	155257083	3	4	93	1	0	0	0	0	1	0	0	0	6998	768	27	2	1623	2	HCN3	1	155257083	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	551497	155257083	93993538	32	27746										
CD1A	909	broad.mit.edu	37	chr1	158227240	158227240	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gttccgtgggcttcatcatcTtggcggtgatagtgccttta	12	9	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:158227240T>G	uc001frt.2	+	5	1446	c.913T>G	c.(913-915)TTG>GTG	p.L305V		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	305	Helical; (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CTTCATCATCTTGGCGGTGAT	0.413													0	0	0	0.01441	0	72	243										G	158227240	T	G	158227240	3	3	93	1	0	0	0	0	1	0	0	0	2974	1606	56	5	931	5	CD1A	1	158227240	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	2970157	158227240	91023381	33	27747										
OR6K6	128371	broad.mit.edu	37	chr1	158725183	158725183	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgagattgcatggatttccaCcttgcctttctgtggctcca	9	11	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:158725183C>T	uc001fsw.1	+	1	578	c.578C>T	c.(577-579)ACC>ATC	p.T193I		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					TGGATTTCCACCTTGCCTTTC	0.478													0	0	0	0.00623	0	41	45										T	158725183	C	T	158725183	3	4	93	1	0	0	0	0	1	0	0	0	11204	507	18	2	580	2	OR6K6	1	158725183	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	497943	158725183	90525438	34	27748										
IGSF9	57549	broad.mit.edu	37	chr1	159906269	159906269	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtagaccccagagctgcctCgctctacccggcggatccgc	11	17	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:159906269C>T	uc001fur.2	-	6	791	c.593G>A	c.(592-594)CGA>CAA	p.R198Q	IGSF9_uc001fuq.2_Missense_Mutation_p.R198Q	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	198	Ig-like 2.|Extracellular (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AGAGCTGCCTCGCTCTACCCG	0.657											OREG0013921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	20	50										T	159906269	C	T	159906269	3	4	93	1	0	0	0	0	1	0	0	0	7605	884	31	1	3010	1	IGSF9	1	159906269	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1181086	159906269	89344352	35	27749										
CD84	8832	broad.mit.edu	37	chr1	160523264	160523264	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctcagcaacccggtgtggtGagtacggaagcccattgcga	14	11	1	1	rs145496946		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:160523264G>C	uc001fwh.3	-	4	688	c.664C>G	c.(664-666)CAC>GAC	p.H222D	CD84_uc001fwf.3_Missense_Mutation_p.H222D|CD84_uc001fwg.3_Missense_Mutation_p.H222D|CD84_uc009wtn.2_Missense_Mutation_p.H222D|CD84_uc001fwi.3_Missense_Mutation_p.H108D|CD84_uc001fwj.2_Missense_Mutation_p.H222D	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	222	Extracellular (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCGGTGTGGTGAGTACGGAAG	0.488													0	0	0	0.014323	0	21	46										C	160523264	G	C	160523264	3	2	93	1	0	0	0	0	1	0	0	0	3042	1290	45	1	393	1	CD84	1	160523264	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	616995	160523264	88727357	36	27750										
PAPPA2	60676	broad.mit.edu	37	chr1	176564329	176564329	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtgatacgctaccaggtggTgaacatctgtgatgatgagg	15	6	1	5			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:176564329T>C	uc001gkz.2	+	3	2753	c.1589T>C	c.(1588-1590)GTG>GCG	p.V530A	PAPPA2_uc001gky.1_Missense_Mutation_p.V530A|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	530	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TACCAGGTGGTGAACATCTGT	0.527													0	0	0	0.007413	0	19	28										C	176564329	T	C	176564329	3	2	93	1	0	0	0	0	1	0	0	0	11433	1696	59	5	1595	5	PAPPA2	1	176564329	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	16041065	176564329	72686292	37	27751										
SOAT1	6646	broad.mit.edu	37	chr1	179320465	179320465	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tttttagtggctttcaacttCattgtcaatgatagtcggaa	8	6	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:179320465C>G	uc001gml.2	+	15	1527	c.1464C>G	c.(1462-1464)TTC>TTG	p.F488L	SOAT1_uc010pni.1_Missense_Mutation_p.F423L|SOAT1_uc001gmm.2_Missense_Mutation_p.F430L|SOAT1_uc010pnj.1_Missense_Mutation_p.F224L|SOAT1_uc010pnk.1_Missense_Mutation_p.F423L	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	488	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	CTTTCAACTTCATTGTCAATG	0.274													0	0	0	0.00874	0	39	97										G	179320465	C	G	179320465	3	3	93	1	0	0	0	0	1	0	0	0	14910	825	29	1	1518	1	SOAT1	1	179320465	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2756136	179320465	69930156	38	27752										
HMCN1	83872	broad.mit.edu	37	chr1	186007984	186007984	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttacatggtacaaagataatCgtctactctcaggttccacc	6	11	2	1	rs149920975		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:186007984C>T	uc001grq.1	+	38	6104	c.5875C>T	c.(5875-5877)CGT>TGT	p.R1959C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1959	Ig-like C2-type 17.			R -> C (in Ref. 1).	response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAAAGATAATCGTCTACTCTC	0.348													0	0	0	0.004007	0	13	96										T	186007984	C	T	186007984	3	4	93	1	0	0	0	0	1	0	0	0	7220	884	31	1	6025	1	HMCN1	1	186007984	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6687519	186007984	63242637	39	27753										
ASPM	259266	broad.mit.edu	37	chr1	197070512	197070512	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ataatggcagcctggtgctgTtcctgaatctgtttttttat	9	7	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:197070512T>G	uc001gtu.2	-	18	8126	c.7869A>C	c.(7867-7869)GAA>GAC	p.E2623D	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.E471D	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2623					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CCTGGTGCTGTTCCTGAATCT	0.343													0	0	0	0.001855	0	13	12										G	197070512	T	G	197070512	3	3	93	1	0	0	0	0	1	0	0	0	1056	1722	60	5	2608	5	ASPM	1	197070512	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	11062528	197070512	52180109	40	27754										
TNNI1	7135	broad.mit.edu	37	chr1	201380568	201380568	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cttggagcccagcagggcccGgagcatggcgtcagccgaga	16	13	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:201380568G>A	uc010ppq.1	-	7	466	c.373C>T	c.(373-375)CGG>TGG	p.R125W	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_Missense_Mutation_p.R104W	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	125					muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						AGCAGGGCCCGGAGCATGGCG	0.597													0	0	0	0.004007	0	17	20										A	201380568	G	A	201380568	3	1	93	1	0	0	0	0	1	0	0	0	16323	1115	39	2	198	2	TNNI1	1	201380568	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4310056	201380568	47870053	41	27755										
OBSCN	84033	broad.mit.edu	37	chr1	228509288	228509288	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cacaggtgggggatgccctgCggctggagtgtgtcgtggcc	19	10	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:228509288C>T	uc009xez.1	+	55	14790	c.14746C>T	c.(14746-14748)CGG>TGG	p.R4916W	OBSCN_uc001hsn.2_Missense_Mutation_p.R4916W	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4916	Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGATGCCCTGCGGCTGGAGTG	0.617													0	0	0	0.008871	0	17	21										T	228509288	C	T	228509288	3	4	93	1	0	0	0	0	1	0	0	0	10812	759	27	2	14960	2	OBSCN	1	228509288	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	27128720	228509288	20741333	42	27756										
ACTN2	88	broad.mit.edu	37	chr1	236908062	236908062	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtggagcagatcgcagccatCgcgcaggagctcaagtatgt	14	10	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:236908062C>T	uc001hyf.2	+	12	1596	c.1392C>T	c.(1390-1392)ATC>ATT	p.I464I	ACTN2_uc001hyg.2_Silent_p.I256I|ACTN2_uc009xgi.1_Silent_p.I464I|ACTN2_uc010pxu.1_Silent_p.I153I|ACTN2_uc001hyh.2_Silent_p.I152I	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	464	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TCGCAGCCATCGCGCAGGAGC	0.657													0	0	0	0.00499	0	16	37										T	236908062	C	T	236908062	2	4	93	1	0	0	0	0	0	0	0	1	205	874	31	1		1	ACTN2	1	236908062	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	8398774	236908062	12342559	43	27757										
ZP4	57829	broad.mit.edu	37	chr1	238053789	238053789	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	attagtacaggaggagacgtTgcctcctggttgaggtttac	13	7	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:238053789T>C	uc001hym.2	-	1	147	c.147A>G	c.(145-147)GCA>GCG	p.A49A	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	49	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GAGGAGACGTTGCCTCCTGGT	0.498													0	0	0	0.000602	0	4	34										C	238053789	T	C	238053789	2	2	93	1	0	0	0	0	0	0	0	1	18215	1799	63	5		5	ZP4	1	238053789	Silent	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	1145727	238053789	11196832	44	27758										
CHRM3	1131	broad.mit.edu	37	chr1	240071762	240071762	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cacagcagcagtgacagttgGaacaacaatgatgctgctgc	11	10	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:240071762G>C	uc001hyp.2	+	5	1790	c.1011G>C	c.(1009-1011)TGG>TGC	p.W337C		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	337	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GTGACAGTTGGAACAACAATG	0.572													0	0	0	0.001984	0	7	13										C	240071762	G	C	240071762	3	2	93	1	0	0	0	0	1	0	0	0	3378	1183	41	1	1013	1	CHRM3	1	240071762	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2017973	240071762	9178859	45	27759										
CHRM3	1131	broad.mit.edu	37	chr1	240071792	240071792	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gatgctgctgcctccctggaGaactccgcctcctccgacga	10	17	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:240071792G>A	uc001hyp.2	+	5	1820	c.1041G>A	c.(1039-1041)GAG>GAA	p.E347E		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	347	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CCTCCCTGGAGAACTCCGCCT	0.572													0	0	0	0.001168	0	5	9										A	240071792	G	A	240071792	2	1	93	1	0	0	0	0	0	0	0	1	3378	933	33	1		1	CHRM3	1	240071792	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	30	240071792	9178829	46	27760										
NLRP3	114548	broad.mit.edu	37	chr1	247588705	247588705	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tggactatttccccaagattGagatcaatctctccaccaga	6	12	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr1:247588705G>A	uc001icr.2	+	5	2098	c.1960G>A	c.(1960-1962)GAG>AAG	p.E654K	NLRP3_uc001ics.2_Missense_Mutation_p.E654K|NLRP3_uc001icu.2_Missense_Mutation_p.E654K|NLRP3_uc001icw.2_Missense_Mutation_p.E654K|NLRP3_uc001icv.2_Missense_Mutation_p.E654K|NLRP3_uc010pyw.1_Missense_Mutation_p.E652K|NLRP3_uc001ict.1_Missense_Mutation_p.E652K	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	654					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCCCAAGATTGAGATCAATCT	0.498													0	0	0	0.008291	0	11	36										A	247588705	G	A	247588705	3	1	93	1	0	0	0	0	1	0	0	0	10478	1291	45	1	1970	1	NLRP3	1	247588705	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	7516913	247588705	1661916	47	27761										
TPO	7173	broad.mit.edu	37	chr2	1459852	1459852	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtctcttcctacccaggtccGggaggtgacaagacatgtca	11	12	2	2	rs144088710		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:1459852G>T	uc002qww.2	+	7	708	c.617G>T	c.(616-618)CGG>CTG	p.R206L	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.R206L|TPO_uc002qwr.2_Missense_Mutation_p.R206L|TPO_uc002qwx.2_Missense_Mutation_p.R206L|TPO_uc010yio.1_Missense_Mutation_p.R206L|TPO_uc010yip.1_Missense_Mutation_p.R206L	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	206	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACCCAGGTCCGGGAGGTGACA	0.502													1	0	0.000602214	0.000602	0.000627841	4	19										T	1459852	G	T	1459852	3	4	93	1	0	0	0	0	1	0	0	0	16407	1116	39	4	639	4	TPO	2	1459852	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		1459852	241739521	48	27762										
BIRC6	57448	broad.mit.edu	37	chr2	32626615	32626615	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagacccaagctcaggagttGattcaaggagaccaactttg	11	9	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:32626615G>A	uc010ezu.2	+	8	1476	c.1342G>A	c.(1342-1344)GAT>AAT	p.D448N		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	448					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCAGGAGTTGATTCAAGGAG	0.398													0	0	0	0.00623	0	42	51										A	32626615	G	A	32626615	3	1	93	1	0	0	0	0	1	0	0	0	1438	1290	45	1	1372	1	BIRC6	2	32626615	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	31166763	32626615	210572758	49	27763										
CYP1B1	1545	broad.mit.edu	37	chr2	38301609	38301609	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gccgcgcgccaccaccgtgcGagtccccggccgccttcttt	11	20	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:38301609G>A	uc002rqo.2	-	3	1326	c.923C>T	c.(922-924)TCG>TTG	p.S308L		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	308					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	ACCACCGTGCGAGTCCCCGGC	0.542													0	0	0	0.010504	0	20	27										A	38301609	G	A	38301609	3	1	93	1	0	0	0	0	1	0	0	0	4151	1059	37	1	716	1	CYP1B1	2	38301609	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5674994	38301609	204897764	50	27764										
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48906488	48906488	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctccagattcatcgaagcaaGaacaaatggaaattctattt	6	8	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:48906488G>A	uc010yol.1	+	8	3362	c.3315G>A	c.(3313-3315)AAG>AAA	p.K1105K	STON1-GTF2A1L_uc002rwp.1_Silent_p.K1152K|GTF2A1L_uc002rws.1_Silent_p.K448K|GTF2A1L_uc010yom.1_Silent_p.K414K|GTF2A1L_uc002rwt.2_Intron	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	1105					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATCGAAGCAAGAACAAATGGA	0.353													0	0	0	0.005443	0	29	35										A	48906488	G	A	48906488	2	1	93	1	0	0	0	0	0	0	0	1	15316	933	33	1		1	STON1-GTF2A1L	2	48906488	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	10604879	48906488	194292885	51	27765										
NRXN1	9378	broad.mit.edu	37	chr2	50318575	50318575	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	attaatgattgcattggattCttcaatggcgatgtcatctg	9	6	4	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:50318575C>G	uc010fbp.2	-	3	1306	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	NRXN1_uc002rxb.3_Missense_Mutation_p.E874Q|NRXN1_uc010fbq.2_Missense_Mutation_p.E1242Q|NRXN1_uc002rxe.3_Missense_Mutation_p.E1202Q	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	167	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCATTGGATTCTTCAATGGCG	0.438													0	0	0	0.004656	0	27	126										G	50318575	C	G	50318575	3	3	93	1	0	0	0	0	1	0	0	0	10665	922	32	1	939	1	NRXN1	2	50318575	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1412087	50318575	192880798	52	27766										
MTIF2	4528	broad.mit.edu	37	chr2	55464514	55464514	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tctgcagccagccacaggaaCttttttcttcccttctgtta	6	13	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:55464514C>A	uc002ryn.2	-	16	2658	c.1921G>T	c.(1921-1923)GTT>TTT	p.V641F	MTIF2_uc010yox.1_Missense_Mutation_p.V310F|MTIF2_uc002ryo.2_Missense_Mutation_p.V641F	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	641					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						GCCACAGGAACTTTTTTCTTC	0.373													1	0	1.08611e-07	0.010729	1.13838e-07	11	49										A	55464514	C	A	55464514	3	1	93	1	0	0	0	0	1	0	0	0	9934	565	20	4	270	4	MTIF2	2	55464514	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	5145939	55464514	187734859	53	27767										
IMMT	10989	broad.mit.edu	37	chr2	86389141	86389141	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagcttcatctactgcctttCtgcgttccttcaatgcaccc	5	16	4	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:86389141C>T	uc002sqz.3	-	8	1242	c.854G>A	c.(853-855)AGA>AAA	p.R285K	IMMT_uc002sqy.3_Missense_Mutation_p.R26K|IMMT_uc002srb.3_Missense_Mutation_p.R274K|IMMT_uc002sra.3_Missense_Mutation_p.R284K|IMMT_uc010ytd.1_Missense_Mutation_p.R273K|IMMT_uc010yte.1_Missense_Mutation_p.R238K|IMMT_uc002src.1_Missense_Mutation_p.R26K|IMMT_uc002srd.2_Missense_Mutation_p.R285K|IMMT_uc002sre.3_Missense_Mutation_p.R273K|IMMT_uc010ytf.1_Missense_Mutation_p.R207K|IMMT_uc010fgs.1_Missense_Mutation_p.R282K	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	285	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						TACTGCCTTTCTGCGTTCCTT	0.428													0	0	0	0.003163	0	12	9										T	86389141	C	T	86389141	3	4	93	1	0	0	0	0	1	0	0	0	7718	913	32	1	1454	1	IMMT	2	86389141	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	30924627	86389141	156810232	54	27768										
GCC2	9648	broad.mit.edu	37	chr2	109086467	109086467	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atatcattgaggctaattctCagcattaccaaaaaaatatt	4	7	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:109086467C>T	uc002tec.2	+	6	836	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	GCC2_uc002ted.2_Nonsense_Mutation_p.Q127*	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	228	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						GGCTAATTCTCAGCATTACCA	0.358													0	0	0	0.011902	0	48	62										T	109086467	C	T	109086467	4	4	93	1	0	0	0	0	0	1	0	0	6286	827	29	1	704	1	GCC2	2	109086467	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	22697326	109086467	134112906	55	27769										
POLR1B	84172	broad.mit.edu	37	chr2	113315529	113315529	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtctattaaaatagcttttGataagaaggctcagaagacc	8	6	2	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:113315529G>C	uc002thw.2	+	8	1781	c.1201G>C	c.(1201-1203)GAT>CAT	p.D401H	POLR1B_uc010fkn.2_Missense_Mutation_p.D345H|POLR1B_uc002thx.2_Missense_Mutation_p.D262H|POLR1B_uc010fko.2_Intron|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Missense_Mutation_p.D439H|POLR1B_uc002thy.2_Missense_Mutation_p.D262H|POLR1B_uc010yxo.1_Missense_Mutation_p.D178H	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	401					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1						AATAGCTTTTGATAAGAAGGC	0.284													0	0	0	0.000602	0	5	12										C	113315529	G	C	113315529	3	2	93	1	0	0	0	0	1	0	0	0	12210	1290	45	1	1231	1	POLR1B	2	113315529	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4229062	113315529	129883844	56	27770										
LRP1B	53353	broad.mit.edu	37	chr2	140995786	140995786	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gttgtgatcatgatctacctCatacatgttataagatggat	8	6	3	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:140995786C>T	uc002tvj.1	-	89	14467	c.13495G>A	c.(13495-13497)GAG>AAG	p.E4499K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4499	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGATCTACCTCATACATGTTA	0.338										TSP Lung(27;0.18)			0	0	0	0.008291	0	11	54										T	140995786	C	T	140995786	3	4	93	1	0	0	0	0	1	0	0	0	8955	835	29	1	316	1	LRP1B	2	140995786	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	27680257	140995786	102203587	57	27771										
OLA1	29789	broad.mit.edu	37	chr2	175006600	175006600	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcctctcacagccaccttttCtagtttatctataatgggcc	5	13	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:175006600C>G	uc002uih.2	-	5	688	c.502G>C	c.(502-504)GAA>CAA	p.E168Q	OLA1_uc002uii.2_Missense_Mutation_p.E10Q|OLA1_uc010fqq.2_Missense_Mutation_p.E168Q|OLA1_uc002uij.2_Missense_Mutation_p.E10Q|OLA1_uc002uik.2_Missense_Mutation_p.E138Q|OLA1_uc010fqr.2_Missense_Mutation_p.E168Q	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	168			E -> Q (in a breast cancer sample; somatic mutation).		ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding	p.E168Q(1)		ovary(1)|breast(1)	2						GCCACCTTTTCTAGTTTATCT	0.328													0	0	0	0.010504	0	18	48										G	175006600	C	G	175006600	3	3	93	1	0	0	0	0	1	0	0	0	10850	922	32	1	716	1	OLA1	2	175006600	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	34010814	175006600	68192773	58	27772										
CIR1	9541	broad.mit.edu	37	chr2	175213677	175213677	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agaatcactgttgttatgccCtgaacacttgtttttctttc	6	9	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:175213677C>T	uc002uim.2	-	10	994	c.901G>A	c.(901-903)GGG>AGG	p.G301R	CIR1_uc002uin.2_Missense_Mutation_p.G175R|CIR1_uc002uio.2_Missense_Mutation_p.G128R|CIR1_uc002uip.2_Missense_Mutation_p.G190R	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	301	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						TTGTTATGCCCTGAACACttg	0.313													0	0	0	0.010818	0	33	66										T	175213677	C	T	175213677	3	4	93	1	0	0	0	0	1	0	0	0	3432	681	24	2	455	2	CIR1	2	175213677	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	207077	175213677	67985696	59	27773										
TTN	7273	broad.mit.edu	37	chr2	179424596	179424596	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctcatttcactgtcaatatCaaataaaggttcttcttctc	3	11	7	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:179424596C>T	uc010zfg.1	-	275	78783	c.78559G>A	c.(78559-78561)GAT>AAT	p.D26187N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D19882N|TTN_uc010zfi.1_Missense_Mutation_p.D19815N|TTN_uc010zfj.1_Missense_Mutation_p.D19690N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27114							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTCAATATCAAATAAAGGT	0.433													0	0	0	0.012213	0	32	63										T	179424596	C	T	179424596	3	4	93	1	0	0	0	0	1	0	0	0	16732	826	29	1	21864	1	TTN	2	179424596	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	4210919	179424596	63774777	60	27774										
CERKL	375298	broad.mit.edu	37	chr2	182438553	182438553	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	taataaacctgggtagcttcTtttttgtgactttgggggtt	11	5	1	1	rs149505471		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:182438553T>A	uc002unx.2	-	3	641	c.540A>T	c.(538-540)AAA>AAT	p.K180N	CERKL_uc002uny.2_Missense_Mutation_p.K180N|CERKL_uc010zfm.1_Intron|CERKL_uc002unz.2_Translation_Start_Site|CERKL_uc002uoa.2_Missense_Mutation_p.K180N|CERKL_uc002uob.2_Intron|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_Intron|CERKL_uc002uod.1_Translation_Start_Site|CERKL_uc002uoe.2_Missense_Mutation_p.K180N	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	180	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GGGTAGCTTCTTTTTTGTGAC	0.333													0	0	0	0.012319	0	19	34										A	182438553	T	A	182438553	3	1	93	1	0	0	0	0	1	0	0	0	3268	1606	56	5	1184	5	CERKL	2	182438553	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	3013957	182438553	60760820	61	27775										
STAT4	6775	broad.mit.edu	37	chr2	191897696	191897696	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aacctaaccttcgcaaggctGagagctgtagtgtttaccga	10	10	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:191897696G>C	uc002usm.1	-	21	2286	c.2032C>G	c.(2032-2034)CAG>GAG	p.Q678E	STAT4_uc002usn.1_Missense_Mutation_p.Q678E|STAT4_uc010zgk.1_Missense_Mutation_p.Q523E|STAT4_uc002uso.2_Missense_Mutation_p.Q678E	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	678					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TCGCAAGGCTGAGAGCTGTAG	0.368													0	0	0	0.010729	0	11	37										C	191897696	G	C	191897696	3	2	93	1	0	0	0	0	1	0	0	0	15266	1299	45	1	230	1	STAT4	2	191897696	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	9459143	191897696	51301677	62	27776										
FZD7	8324	broad.mit.edu	37	chr2	202900750	202900750	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atgaaacacgacggcaccaaGaccgagaagctggagaagct	12	10	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:202900750G>C	uc002uyw.1	+	1	1441	c.1380G>C	c.(1378-1380)AAG>AAC	p.K460N		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	460	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						ACGGCACCAAGACCGAGAAGC	0.592											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	16	35										C	202900750	G	C	202900750	3	2	93	1	0	0	0	0	1	0	0	0	6135	933	33	1	1382	1	FZD7	2	202900750	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	11003054	202900750	40298623	63	27777										
SPHKAP	80309	broad.mit.edu	37	chr2	228882308	228882308	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctggcctcggagtcttcctCaggaatgctttcgcagctgg	12	13	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr2:228882308C>G	uc002vpq.2	-	7	3309	c.3262G>C	c.(3262-3264)GAG>CAG	p.E1088Q	SPHKAP_uc002vpp.2_Missense_Mutation_p.E1088Q|SPHKAP_uc010zlx.1_Missense_Mutation_p.E1088Q	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1088						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAGTCTTCCTCAGGAATGCTT	0.632													0	0	0	0.013537	0	10	34										G	228882308	C	G	228882308	3	3	93	1	0	0	0	0	1	0	0	0	15047	835	29	1	1864	1	SPHKAP	2	228882308	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	25981558	228882308	14317065	64	27778										
HRH1	3269	broad.mit.edu	37	chr3	11301783	11301783	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagaggatcagatgttaggtGatagccaatccttctctcga	10	9	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:11301783G>A	uc010hdr.2	+	2	1402	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N	HRH1_uc010hds.2_Missense_Mutation_p.D354N|HRH1_uc010hdt.2_Missense_Mutation_p.D354N|HRH1_uc003bwb.3_Missense_Mutation_p.D354N	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	354	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GATGTTAGGTGATAGCCAATC	0.527													0	0	0	0.013726	0	35	49										A	11301783	G	A	11301783	3	1	93	1	0	0	0	0	1	0	0	0	7355	1290	45	1	1062	1	HRH1	3	11301783	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		11301783	186720647	65	27779										
FGD5	152273	broad.mit.edu	37	chr3	14922086	14922086	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tttcctcccacaggtggaagGacagtccagagcccttgtca	10	13	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:14922086G>A	uc003bzc.2	+	3	2776	c.2666G>A	c.(2665-2667)GGA>GAA	p.G889E	FGD5_uc011avk.1_Missense_Mutation_p.G889E|FGD5_uc003bzd.2_5'Flank	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	889					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CAGGTGGAAGGACAGTCCAGA	0.527													0	0	0	0.003163	0	16	22										A	14922086	G	A	14922086	3	1	93	1	0	0	0	0	1	0	0	0	5836	1174	41	1	2676	1	FGD5	3	14922086	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3620303	14922086	183100344	66	27780										
FGD5	152273	broad.mit.edu	37	chr3	14964612	14964612	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aagtacctgaaggacaggatGgccaaggtctgcgacggctg	15	9	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:14964612G>A	uc003bzc.2	+	16	3977	c.3867G>A	c.(3865-3867)ATG>ATA	p.M1289I	FGD5_uc011avk.1_Missense_Mutation_p.M1289I|FGD5_uc003bzd.2_Missense_Mutation_p.M367I	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1289	FYVE-type.			M -> T (in Ref. 5; CAE45896).	actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						AGGACAGGATGGCCAAGGTCT	0.607													0	0	0	0.009535	0	31	50										A	14964612	G	A	14964612	3	1	93	1	0	0	0	0	1	0	0	0	5836	1348	47	2	3929	2	FGD5	3	14964612	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	42526	14964612	183057818	67	27781										
SACM1L	22908	broad.mit.edu	37	chr3	45773624	45773624	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttttattggatcaggtagcaGaaatgcaagatgaattaagg	11	3	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:45773624G>C	uc003cos.2	+	13	1285	c.1081G>C	c.(1081-1083)GAA>CAA	p.E361Q	SACM1L_uc011bag.1_Missense_Mutation_p.E258Q|SACM1L_uc011bah.1_Missense_Mutation_p.E295Q|SACM1L_uc003cot.2_5'Flank	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	361	SAC.					Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		TCAGGTAGCAGAAATGCAAGA	0.333													0	0	0	0.00632	0	29	63										C	45773624	G	C	45773624	3	2	93	1	0	0	0	0	1	0	0	0	13803	943	33	1	1131	1	SACM1L	3	45773624	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	30809012	45773624	152248806	68	27782										
TCTA	6988	broad.mit.edu	37	chr3	49452277	49452277	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atggcagcaaacgaacctctCaaaacccacagagaataagg	8	11	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:49452277C>G	uc003cwv.3	+	3	515	c.294C>G	c.(292-294)CTC>CTG	p.L98L	RHOA_uc010hku.2_5'Flank|RHOA_uc003cwu.2_5'Flank	NM_022171	NP_071503	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	98	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACGAACCTCTCAAAACCCACA	0.522													0	0	0	0.001984	0	5	23										G	49452277	C	G	49452277	2	3	93	1	0	0	0	0	0	0	0	1	15713	813	29	1		1	TCTA	3	49452277	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3678653	49452277	148570153	69	27783										
MST1	4485	broad.mit.edu	37	chr3	49722087	49722087	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cacgctggttcagggtcacaGatctttagcaagaatggggg	14	8	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:49722087G>T	uc003cxg.2	-	16	1844	c.1772C>A	c.(1771-1773)TCT>TAT	p.S591Y		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	577	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CAGGGTCACAGATCTTTAGCA	0.602													1	0	2.32078e-09	0.003163	2.44556e-09	15	53										T	49722087	G	T	49722087	3	4	93	1	0	0	0	0	1	0	0	0	9890	942	33	3	417	3	MST1	3	49722087	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	269810	49722087	148300343	70	27784										
CACNA2D2	9254	broad.mit.edu	37	chr3	50403560	50403560	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tattgtagagtgccagcatcAggttggcatccacctcactg	10	11	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:50403560A>G	uc003daq.2	-	33	2803	c.2765T>C	c.(2764-2766)CTG>CCG	p.L922P	CACNA2D2_uc003dap.2_Missense_Mutation_p.L915P|CACNA2D2_uc003dao.2_5'Flank	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	922	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TGCCAGCATCAGGTTGGCATC	0.567													0	0	0	0.004672	0	3	92										G	50403560	A	G	50403560	3	3	93	1	0	0	0	0	1	0	0	0	2549	188	7	5	721	5	CACNA2D2	3	50403560	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	681473	50403560	147618870	71	27785										
STAB1	23166	broad.mit.edu	37	chr3	52547747	52547747	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttccagagggtctgggtgcaGaatgccagcgtggatgtggc	17	8	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:52547747G>C	uc003dej.2	+	31	3359	c.3285G>C	c.(3283-3285)CAG>CAC	p.Q1095H		NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1095	FAS1 3.|Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TCTGGGTGCAGAATGCCAGCG	0.597													0	0	0	0.001168	0	6	17										C	52547747	G	C	52547747	3	2	93	1	0	0	0	0	1	0	0	0	15236	933	33	1	3407	1	STAB1	3	52547747	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2144187	52547747	145474683	72	27786										
NT5DC2	64943	broad.mit.edu	37	chr3	52558714	52558714	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aaggtgcggaagatgctgccGaactgcgcattgaacagggc	15	9	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:52558714G>A	uc003deo.2	-	14	1759	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	NT5DC2_uc003dem.2_Silent_p.F315F|NT5DC2_uc003den.2_Silent_p.F482F|NT5DC2_uc010hmi.2_Silent_p.F457F|NT5DC2_uc010hmj.2_Silent_p.F261F	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	445							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		AGATGCTGCCGAACTGCGCAT	0.627													0	0	0	0.003163	0	15	38										A	52558714	G	A	52558714	2	1	93	1	0	0	0	0	0	0	0	1	10691	1049	37	1		1	NT5DC2	3	52558714	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	10967	52558714	145463716	73	27787										
CGGBP1	8545	broad.mit.edu	37	chr3	88104763	88104763	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agcacggactgctgggtgatCagccttctcaagtgggatgt	14	9	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:88104763C>T	uc003dqs.2	-	4	876	c.364G>A	c.(364-366)GAT>AAT	p.D122N	CGGBP1_uc003dqt.2_Missense_Mutation_p.D122N|CGGBP1_uc003dqu.2_Missense_Mutation_p.D122N	NM_001008390	NP_001008391	Q9UFW8	CGBP1_HUMAN	CGG triplet repeat binding protein 1	122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding				0		Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00359)|Lung(72;0.00677)		GCTGGGTGATCAGCCTTCTCA	0.488													0	0	0	0.010504	0	22	54										T	88104763	C	T	88104763	3	4	93	1	0	0	0	0	1	0	0	0	3302	826	29	1	143	1	CGGBP1	3	88104763	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	35546049	88104763	109917667	74	27788										
KIAA1524	57650	broad.mit.edu	37	chr3	108271090	108271090	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagattcttaccttaatgctCaactcttttcttatctgttc	3	11	5	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:108271090C>G	uc003dxb.3	-	20	2807	c.2538G>C	c.(2536-2538)TTG>TTC	p.L846F		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	846	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						CCTTAATGCTCAACTCTTTTC	0.313													0	0	0	0.013537	0	12	26										G	108271090	C	G	108271090	3	3	93	1	0	0	0	0	1	0	0	0	8239	825	29	1	187	1	KIAA1524	3	108271090	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	20166327	108271090	89751340	75	27789										
BOC	91653	broad.mit.edu	37	chr3	112998700	112998700	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acaagtttcgagtccgggctCtgaacatgctgggggagagc	15	9	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:112998700C>G	uc003dzx.2	+	13	2671	c.2050C>G	c.(2050-2052)CTG>GTG	p.L684V	BOC_uc003dzy.2_Missense_Mutation_p.L684V|BOC_uc003dzz.2_Missense_Mutation_p.L685V|BOC_uc003eab.2_Missense_Mutation_p.L385V|BOC_uc003eac.2_5'UTR	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	684	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			AGTCCGGGCTCTGAACATGCT	0.612													0	0	0	0.01441	0	55	118										G	112998700	C	G	112998700	3	3	93	1	0	0	0	0	1	0	0	0	1481	912	32	1	2092	1	BOC	3	112998700	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	4727610	112998700	85023730	76	27790										
PLXND1	23129	broad.mit.edu	37	chr3	129289674	129289674	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcgcccagggactcgttgacCgagcagtggatgattctgtc	14	11	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:129289674C>T	uc003emx.2	-	19	3805	c.3705G>A	c.(3703-3705)TCG>TCA	p.S1235S		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1235	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						ACTCGTTGACCGAGCAGTGGA	0.622													0	0	0	0.01441	0	115	159										T	129289674	C	T	129289674	2	4	93	1	0	0	0	0	0	0	0	1	12127	639	23	2		2	PLXND1	3	129289674	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	16290974	129289674	68732756	77	27791										
CEP70	80321	broad.mit.edu	37	chr3	138219388	138219388	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aacaatagcttgcaaagtttGaaagtgtggcatattgctgt	10	5	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:138219388G>A	uc003esl.2	-	15	1588	c.1390C>T	c.(1390-1392)CAA>TAA	p.Q464*	CEP70_uc011bmk.1_Nonsense_Mutation_p.Q444*|CEP70_uc011bml.1_Nonsense_Mutation_p.Q446*|CEP70_uc011bmm.1_Nonsense_Mutation_p.Q312*|CEP70_uc003esm.2_Nonsense_Mutation_p.Q464*	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	464					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TGCAAAGTTTGAAAGTGTGGC	0.323													0	0	0	0.01441	0	116	255										A	138219388	G	A	138219388	4	1	93	1	0	0	0	0	0	1	0	0	3259	1299	45	1	419	1	CEP70	3	138219388	Nonsense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	8929714	138219388	59803042	78	27792										
RBP1	5947	broad.mit.edu	37	chr3	139258320	139258320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	accgagggcgcgcaggtactCctcgaaattctcgttgacca	11	13	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:139258320C>T	uc003eti.2	-	1	352	c.241G>A	c.(241-243)GAG>AAG	p.E81K	RBP1_uc011bmx.1_Missense_Mutation_p.E81K|RBP1_uc010huj.2_RNA|RBP1_uc011bmy.1_Missense_Mutation_p.E81K	NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	19						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CGCAGGTACTCCTCGAAATTC	0.677													0	0	0	0.013537	0	11	8										T	139258320	C	T	139258320	3	4	93	1	0	0	0	0	1	0	0	0	13155	864	30	1	436	1	RBP1	3	139258320	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1038932	139258320	58764110	79	27793										
TNIK	23043	broad.mit.edu	37	chr3	170945999	170945999	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctgcaagctggcccgttttGacatgacgaccctgtgaaga	12	11	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:170945999G>C	uc003fhh.2	-	3	480	c.135C>G	c.(133-135)GTC>GTG	p.V45V	TNIK_uc003fhi.2_Silent_p.V45V|TNIK_uc003fhj.2_Silent_p.V45V|TNIK_uc003fhk.2_Silent_p.V45V|TNIK_uc003fhl.2_Silent_p.V45V|TNIK_uc003fhm.2_Silent_p.V45V|TNIK_uc003fhn.2_Silent_p.V45V|TNIK_uc003fho.2_Silent_p.V45V	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	45	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GGCCCGTTTTGACATGACGAC	0.338													0	0	0	0.01441	0	81	42										C	170945999	G	C	170945999	2	2	93	1	0	0	0	0	0	0	0	1	16310	1277	45	1		1	TNIK	3	170945999	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	31687679	170945999	27076431	80	27794										
MCF2L2	23101	broad.mit.edu	37	chr3	183014889	183014889	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggcgatatcaaccccttctcGagactggcacttgtctacag	9	13	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:183014889G>C	uc003fli.1	-	12	1462	c.1372C>G	c.(1372-1374)CGA>GGA	p.R458G	MCF2L2_uc003flj.1_Missense_Mutation_p.R458G|MCF2L2_uc011bqr.1_Intron|uc003fln.1_RNA|uc003flo.2_5'Flank	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	458					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCCCTTCTCGAGACTGGCAC	0.517													0	0	0	0.006214	0	8	90										C	183014889	G	C	183014889	3	2	93	1	0	0	0	0	1	0	0	0	9380	1066	37	1	2048	1	MCF2L2	3	183014889	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	12068890	183014889	15007541	81	27795										
EIF2B5	8893	broad.mit.edu	37	chr3	183858320	183858320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcatccgccgatgggtctacCctctcaccccagaggcgaac	9	17	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:183858320C>T	uc003fmp.2	+	7	1322	c.958C>T	c.(958-960)CCT>TCT	p.P320S	EIF2B5_uc003fmq.2_Missense_Mutation_p.P41S|EIF2B5_uc003fmr.2_5'Flank	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	320					astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATGGGTCTACCCTCTCACCCC	0.577													0	0	0	0.01441	0	93	129										T	183858320	C	T	183858320	3	4	93	1	0	0	0	0	1	0	0	0	5004	623	22	2	984	2	EIF2B5	3	183858320	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	843431	183858320	14164110	82	27796										
LSG1	55341	broad.mit.edu	37	chr3	194392818	194392818	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agtcagtgtgacgatggcttCggctccgctgagtctgatgg	15	9	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr3:194392818C>T	uc003fui.2	-	1	389	c.74G>A	c.(73-75)CGA>CAA	p.R25Q		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	25					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		ACGATGGCTTCGGCTCCGCTG	0.567													0	0	0	0.007291	0	27	47										T	194392818	C	T	194392818	3	4	93	1	0	0	0	0	1	0	0	0	9049	884	31	1	1958	1	LSG1	3	194392818	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	10534498	194392818	3629612	83	27797										
SEPSECS	51091	broad.mit.edu	37	chr4	25160685	25160685	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	attgcaagttcatgtaaaaaGagttcaagtgtactttcatc	7	6	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:25160685G>C	uc003grg.2	-	2	372	c.159C>G	c.(157-159)CTC>CTG	p.L53L	uc003grj.2_5'Flank|PI4K2B_uc011bxs.1_5'Flank|SEPSECS_uc003gri.2_Silent_p.L52L|SEPSECS_uc003grh.2_Intron	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)	53					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	CATGTAAAAAGAGTTCAAGTG	0.383													0	0	0	0.007291	0	27	64										C	25160685	G	C	25160685	2	2	93	1	0	0	0	0	0	0	0	1	14058	929	33	1		1	SEPSECS	4	25160685	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		25160685	165993591	84	27798										
FRAS1	80144	broad.mit.edu	37	chr4	79360104	79360104	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	catctggttactgatagcttCtatttctctgtctctgacat	6	10	4	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:79360104C>G	uc003hlb.2	+	40	5855	c.5415C>G	c.(5413-5415)TTC>TTG	p.F1805L	FRAS1_uc003hkw.2_Missense_Mutation_p.F1805L|FRAS1_uc010ijj.1_Missense_Mutation_p.F225L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1804	CSPG 6.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTGATAGCTTCTATTTCTCTG	0.388													0	0	0	0.00278	0	23	91										G	79360104	C	G	79360104	3	3	93	1	0	0	0	0	1	0	0	0	6042	912	32	1	5573	1	FRAS1	4	79360104	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	54199419	79360104	111794172	85	27799										
HERC5	51191	broad.mit.edu	37	chr4	89415386	89415386	+	Frame_Shift_Del	DEL	T	T	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttccctgttcaattgcaatgTtgccaaccttcctttcccac							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:89415386delT	uc003hrt.2	+	18	2501	c.2348delT	c.(2347-2349)GTTfs	p.V783fs	HERC5_uc011cdm.1_Frame_Shift_Del_p.V421fs	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	783	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		AATTGCAATGTTGCCAACCTT	0.368																		12	37	---	---								-	89415386	T	-	89415386	7	5	93	1	0	1	0	1	0	0	0	0	7061	1725	60	0	2418	0	HERC5	4	89415386	Frame_Shift_Del	DEL	T	TCGA-G2-A2EF-01A-12D-A18F-08	10055282	89415386	101738890	86	27800										
PPP3CA	5530	broad.mit.edu	37	chr4	101984485	101984485	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gttgaattgcctgatattcaTaacattgttctcatacttca	5	8	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:101984485T>C	uc011cen.1	-	9	1660	c.985A>G	c.(985-987)ATG>GTG	p.M329V	PPP3CA_uc003hvu.2_Missense_Mutation_p.M329V|PPP3CA_uc010ilj.2_Intron|PPP3CA_uc003hvt.2_Missense_Mutation_p.M316V|PPP3CA_uc003hvs.2_Missense_Mutation_p.M262V|PPP3CA_uc010ilk.2_Missense_Mutation_p.M97V	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	329					protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		CTGATATTCATAACATTGTTC	0.363													0	0	0	0.006214	0	10	10										C	101984485	T	C	101984485	3	2	93	1	0	0	0	0	1	0	0	0	12397	1406	49	5	604	5	PPP3CA	4	101984485	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	12569099	101984485	89169791	87	27801										
FAT4	79633	broad.mit.edu	37	chr4	126241535	126241535	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aaatcaacactctttgttgaTgttttggaaaacatgagaat	7	5	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:126241535T>A	uc003ifj.3	+	1	3969	c.3969T>A	c.(3967-3969)GAT>GAA	p.D1323E		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1323	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTTTGTTGATGTTTTGGAAA	0.368													0	0	0	0.007413	0	19	41										A	126241535	T	A	126241535	3	1	93	1	0	0	0	0	1	0	0	0	5692	1461	51	5	3971	5	FAT4	4	126241535	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	24257050	126241535	64912741	88	27802										
PCDH10	57575	broad.mit.edu	37	chr4	134072451	134072451	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttttcagcgtgactgaccgcGactcagaggagaatgggcag	14	9	2	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:134072451G>C	uc003iha.2	+	1	1982	c.1156G>C	c.(1156-1158)GAC>CAC	p.D386H	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.D386H	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	386	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GACTGACCGCGACTCAGAGGA	0.587													0	0	0	0.00632	0	29	70										C	134072451	G	C	134072451	3	2	93	1	0	0	0	0	1	0	0	0	11507	1058	37	1	1158	1	PCDH10	4	134072451	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	7830916	134072451	57081825	89	27803										
MAML3	55534	broad.mit.edu	37	chr4	140651796	140651796	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	actgcatggggcctgtggttCggggaagtccaactggatgc	16	9	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:140651796C>T	uc003ihz.1	-	4	2845	c.2093G>A	c.(2092-2094)CGA>CAA	p.R698Q	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.R165Q	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	698	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					GCCTGTGGTTCGGGGAAGTCC	0.632													0	0	0	0.000602	0	4	12										T	140651796	C	T	140651796	3	4	93	1	0	0	0	0	1	0	0	0	9207	884	31	1	1323	1	MAML3	4	140651796	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6579345	140651796	50502480	90	27804										
RAPGEF2	9693	broad.mit.edu	37	chr4	160244690	160244690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agcagaaatactgtgcatggGaaatagttttggtgtctctc	11	6	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr4:160244690G>A	uc003iqg.3	+	5	897	c.587G>A	c.(586-588)GGA>GAA	p.G196E		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	196	cNMP.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CTGTGCATGGGAAATAGTTTT	0.378													0	0	0	0.013537	0	12	30										A	160244690	G	A	160244690	3	1	93	1	0	0	0	0	1	0	0	0	13044	1174	41	1	605	1	RAPGEF2	4	160244690	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	19592894	160244690	30909586	91	27805										
CCT5	22948	broad.mit.edu	37	chr5	10254942	10254942	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aattggagatggaaccacagGagtggttggtaagaaaagac	14	4	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:10254942G>A	uc003jeq.2	+	3	494	c.323G>A	c.(322-324)GGA>GAA	p.G108E	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Missense_Mutation_p.G108E|CCT5_uc010its.2_Missense_Mutation_p.G108E|CCT5_uc011cmr.1_Intron|CCT5_uc011cms.1_Missense_Mutation_p.G70E|CCT5_uc011cmt.1_Intron	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	108					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GGAACCACAGGAGTGGTTGGT	0.418													0	0	0	0.010818	0	31	29										A	10254942	G	A	10254942	3	1	93	1	0	0	0	0	1	0	0	0	2956	1174	41	1	333	1	CCT5	5	10254942	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		10254942	170660318	92	27806										
TRIO	7204	broad.mit.edu	37	chr5	14497101	14497101	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttatcggaagtcacgggaagGactcagcaacaaggtatctg	12	8	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:14497101G>A	uc003jff.2	+	50	8000	c.7994G>A	c.(7993-7995)GGA>GAA	p.G2665E	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2665					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCACGGGAAGGACTCAGCAAC	0.493													0	0	0	0.008291	0	11	45										A	14497101	G	A	14497101	3	1	93	1	0	0	0	0	1	0	0	0	16549	1174	41	1	8192	1	TRIO	5	14497101	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4242159	14497101	166418159	93	27807										
CDH6	1004	broad.mit.edu	37	chr5	31317518	31317518	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atgctgttgacaaggatgacCcttatagtggacaccaattt	9	8	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:31317518C>G	uc003jhe.1	+	10	1875	c.1549C>G	c.(1549-1551)CCT>GCT	p.P517A	CDH6_uc003jhd.1_Missense_Mutation_p.P517A	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	517	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CAAGGATGACCCTTATAGTGG	0.398													0	0	0	0.009096	0	4	110										G	31317518	C	G	31317518	3	3	93	1	0	0	0	0	1	0	0	0	3114	623	22	4	1583	4	CDH6	5	31317518	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	16820417	31317518	149597742	94	27808										
RPL37	6167	broad.mit.edu	37	chr5	40834293	40834293	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	caaactgtacctgaatctgcGgtatacaatttttaggtgcc	8	9	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:40834293G>A	uc003jme.1	-	3	314	c.214C>T	c.(214-216)CGC>TGC	p.R72C	SNORD72_uc003jmf.1_5'Flank	NM_000997	NP_000988	P61927	RL37_HUMAN	ribosomal protein L37	72					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	metal ion binding|protein binding|rRNA binding|structural constituent of ribosome				0		Breast(839;0.238)				CTGAATCTGCGGTATACAATT	0.398													0	0	0	0.013537	0	12	71										A	40834293	G	A	40834293	3	1	93	1	0	0	0	0	1	0	0	0	13589	1116	39	2	87	2	RPL37	5	40834293	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	9516775	40834293	140080967	95	27809										
HEATR7B2	133558	broad.mit.edu	37	chr5	41057463	41057463	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtcagtatttgttttaggctCtaaagtggaaactcccacag	9	8	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:41057463C>G	uc003jmj.3	-	8	1247	c.757_splice	c.e8-1	p.S253_splice	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2								binding			ovary(6)|central_nervous_system(2)	8						GTTTTAGGCTCTAAAGTGGAA	0.433													0	0	0	0.000602	0	5	1										G	41057463	C	G	41057463	5	3	93	1	0	0	0	0	0	0	1	0	7035	927	32	1	4141	1	HEATR7B2	5	41057463	Splice_Site	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	223170	41057463	139857797	96	27810										
MAST4	375449	broad.mit.edu	37	chr5	66449324	66449324	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccggcatgccaggcaggactGaaggctggagatcttatcac	13	11	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:66449324G>A	uc003jut.1	+	25	3065	c.2997G>A	c.(2995-2997)CTG>CTA	p.L999L	MAST4_uc003juw.2_Silent_p.L927L	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1191	PDZ.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGGCAGGACTGAAGGCTGGAG	0.428													0	0	0	0.001168	0	5	8										A	66449324	G	A	66449324	2	1	93	1	0	0	0	0	0	0	0	1	9327	1277	45	1		1	MAST4	5	66449324	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	25391861	66449324	114465936	97	27811										
PIK3R1	5295	broad.mit.edu	37	chr5	67576548	67576548	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccctatgcttttcagattctCagcagccaggtaagtgaaag	9	10	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:67576548C>G	uc003jva.2	+	6	1387	c.827C>G	c.(826-828)TCA>TGA	p.S276*	PIK3R1_uc003jvb.2_Nonsense_Mutation_p.S276*	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	276	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	TTCAGATTCTCAGCAGCCAGG	0.383			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			0	0	0	0.008291	0	11	31										G	67576548	C	G	67576548	4	3	93	1	0	0	0	0	0	1	0	0	11918	838	29	1	845	1	PIK3R1	5	67576548	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1127224	67576548	113338712	98	27812										
GPR98	84059	broad.mit.edu	37	chr5	90074805	90074805	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagcaggggagctcctctttGaagcaggggagatgaggaaa	16	7	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:90074805G>C	uc003kju.2	+	64	13069	c.12973G>C	c.(12973-12975)GAA>CAA	p.E4325Q	GPR98_uc003kjt.2_Missense_Mutation_p.E2031Q|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4325	Extracellular (Potential).|Calx-beta 29.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCTCCTCTTTGAAGCAGGGGA	0.488													0	0	0	0.005443	0	28	61										C	90074805	G	C	90074805	3	2	93	1	0	0	0	0	1	0	0	0	6721	1291	45	1	13227	1	GPR98	5	90074805	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	22498257	90074805	90840455	99	27813										
VDAC1	7416	broad.mit.edu	37	chr5	133326753	133326753	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtattccatttctctgtaaaCgtcaggccgtactcagtcca	7	12	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:133326753C>T	uc003kyp.1	-	4	309	c.210G>A	c.(208-210)ACG>ACA	p.T70T	VDAC1_uc003kyq.1_Silent_p.T70T|VDAC1_uc003kyr.1_Silent_p.T70T	NM_003374	NP_003365	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	70	Beta stranded.				apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	TCTCTGTAAACGTCAGGCCGT	0.458													0	0	0	0.010729	0	12	80										T	133326753	C	T	133326753	2	4	93	1	0	0	0	0	0	0	0	1	17143	523	19	2		2	VDAC1	5	133326753	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	43251948	133326753	47588507	100	27814										
CXCL14	9547	broad.mit.edu	37	chr5	134910273	134910273	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggggcgtacctgcgcttctcGttccaggcgttgtaccactt	12	13	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:134910273G>A	uc003lay.2	-	3	774	c.309C>T	c.(307-309)AAC>AAT	p.N103N		NM_004887	NP_004878	O95715	CXL14_HUMAN	small inducible cytokine B14 precursor	103					cell-cell signaling|chemotaxis|immune response|signal transduction	extracellular space|Golgi apparatus	chemokine activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGCGCTTCTCGTTCCAGGCGT	0.493													0	0	0	0.006214	0	9	20										A	134910273	G	A	134910273	2	1	93	1	0	0	0	0	0	0	0	1	4082	1136	40	2		2	CXCL14	5	134910273	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1583520	134910273	46004987	101	27815										
PCDHGA2	56113	broad.mit.edu	37	chr5	140718701	140718701	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcgccaaggacttgggtttgGagcccctggcactggcagag	15	11	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:140718701G>C	uc003ljk.1	+	1	348	c.163G>C	c.(163-165)GAG>CAG	p.E55Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E55Q	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	55	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTGGGTTTGGAGCCCCTGGC	0.617											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	19	42										C	140718701	G	C	140718701	3	2	93	1	0	0	0	0	1	0	0	0	11554	1175	41	1	165	1	PCDHGA2	5	140718701	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5808428	140718701	40196559	102	27816										
PCDHGA8	9708	broad.mit.edu	37	chr5	140774463	140774463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gccttacactctatctcgtgGtggcagtggctgccatctcc	10	14	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:140774463G>A	uc003lkd.1	+	1	2981	c.2083G>A	c.(2083-2085)GTG>ATG	p.V695M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.V695M	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	695	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATCTCGTGGTGGCAGTGGC	0.607													0	0	0	0.006214	0	7	22										A	140774463	G	A	140774463	3	1	93	1	0	0	0	0	1	0	0	0	11560	1261	44	2	2085	2	PCDHGA8	5	140774463	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	55762	140774463	40140797	103	27817										
PCDH12	51294	broad.mit.edu	37	chr5	141336156	141336156	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtatatttgggccactgctCtctgtccagtgtggcattgg	13	9	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:141336156C>T	uc003llx.2	-	1	2472	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	421	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCACTGCTCTCTGTCCAGT	0.498													0	0	0	0.005524	0	38	78										T	141336156	C	T	141336156	3	4	93	1	0	0	0	0	1	0	0	0	11510	922	32	1	2309	1	PCDH12	5	141336156	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	561693	141336156	39579104	104	27818										
TIMD4	91937	broad.mit.edu	37	chr5	156381553	156381553	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtcaaggagacatcacctctCgggatagtcccctgaagtct	10	12	4	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:156381553C>T	uc003lwh.2	-	2	330	c.273G>A	c.(271-273)CCG>CCA	p.P91P	TIMD4_uc010jii.2_Silent_p.P91P	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	91	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATCACCTCTCGGGATAGTCC	0.517													0	0	0	0.008871	0	20	39										T	156381553	C	T	156381553	2	4	93	1	0	0	0	0	0	0	0	1	15900	871	31	1		1	TIMD4	5	156381553	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	15045397	156381553	24533707	105	27819										
CYFIP2	26999	broad.mit.edu	37	chr5	156788517	156788517	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	accagctgaaggacatcattGagtacgcagagctcaaaaca	9	10	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:156788517G>A	uc003lwq.2	+	28	3088	c.2950G>A	c.(2950-2952)GAG>AAG	p.E984K	CYFIP2_uc011ddn.1_Missense_Mutation_p.E958K|CYFIP2_uc011ddo.1_Missense_Mutation_p.E788K|CYFIP2_uc003lwr.2_Missense_Mutation_p.E984K|CYFIP2_uc003lws.2_Missense_Mutation_p.E984K|CYFIP2_uc003lwt.2_Missense_Mutation_p.E887K|CYFIP2_uc011ddp.1_Missense_Mutation_p.E718K	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1009					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGACATCATTGAGTACGCAGA	0.542													0	0	0	0.013537	0	11	19										A	156788517	G	A	156788517	3	1	93	1	0	0	0	0	1	0	0	0	4138	1291	45	1	3048	1	CYFIP2	5	156788517	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	406964	156788517	24126743	106	27820										
EIF4E1B	253314	broad.mit.edu	37	chr5	176070159	176070159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggcagcagagaggacgcccaCaggagaaaagtctccaaact	12	11	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:176070159C>T	uc010jkf.1	+	4	676	c.92C>T	c.(91-93)ACA>ATA	p.T31I		NM_001099408	NP_001092878	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E	31					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGACGCCCACAGGAGAAAAG	0.498													0	0	0	0.008871	0	19	26										T	176070159	C	T	176070159	3	4	93	1	0	0	0	0	1	0	0	0	5029	478	17	2	98	2	EIF4E1B	5	176070159	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	19281642	176070159	4845101	107	27821										
CNOT6	57472	broad.mit.edu	37	chr5	180000991	180000991	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tttctgttgtttttcagggtAtaatagactacattttctat	6	5	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr5:180000991A>C	uc003mlx.2	+	12	1814	c.1465A>C	c.(1465-1467)ATA>CTA	p.I489L	CNOT6_uc010jld.2_Missense_Mutation_p.I489L|CNOT6_uc010jle.2_Missense_Mutation_p.I484L	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	489					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		TTTTCAGGGTATAATAGACTA	0.418													0	0	0	0.003163	0	15	33										C	180000991	A	C	180000991	3	2	93	1	0	0	0	0	1	0	0	0	3622	449	16	5	1507	5	CNOT6	5	180000991	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	3930832	180000991	914269	108	27822										
FOXQ1	94234	broad.mit.edu	37	chr6	1313255	1313256	+	Frame_Shift_Ins	INS	-	-	GC													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cgcgggcggcgcggggagcgINSgcgagggtgcacgcagcaag							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:1313255_1313256insGC	uc003mtl.3	+	1	581_582	c.316_317insGC	c.(316-318)GGCfs	p.G106fs		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	106					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		cgcggggagcggcgagggtgCA	0.322																		7	11	---	---								GC	1313256	-	GC	1313255	7	5	93	1	0	1	1	0	0	0	0	0	6030	1116	39	0	318	0	FOXQ1	6	1313255	Frame_Shift_Ins	INS	-	TCGA-G2-A2EF-01A-12D-A18F-08		1313255	169801812	109	27823										
GMDS	2762	broad.mit.edu	37	chr6	1726704	1726704	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtcacgtgaactttgccggtCtctttacatctgcccacttc	7	14	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:1726704C>G	uc003mtq.2	-	9	1123	c.933G>C	c.(931-933)GAG>GAC	p.E311D		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	311					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTTTGCCGGTCTCTTTACATC	0.493													0	0	0	0.014323	0	19	95										G	1726704	C	G	1726704	3	3	93	1	0	0	0	0	1	0	0	0	6486	912	32	1	197	1	GMDS	6	1726704	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	413449	1726704	169388363	110	27824										
GMDS	2762	broad.mit.edu	37	chr6	1726724	1726724	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctctttacatctgcccacttCattttcattctttccttccc	1	16	5	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:1726724C>T	uc003mtq.2	-	9	1103	c.913G>A	c.(913-915)GAA>AAA	p.E305K		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	305					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		CTGCCCACTTCATTTTCATTC	0.493													0	0	0	0.006122	0	18	90										T	1726724	C	T	1726724	3	4	93	1	0	0	0	0	1	0	0	0	6486	835	29	1	217	1	GMDS	6	1726724	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	20	1726724	169388343	111	27825										
DSP	1832	broad.mit.edu	37	chr6	7584100	7584100	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tactggtctgctcttgctttCagtacagaagagaagcatgt	10	8	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:7584100C>T	uc003mxp.1	+	24	6884	c.6605C>T	c.(6604-6606)TCA>TTA	p.S2202L	DSP_uc003mxq.1_Missense_Mutation_p.S1603L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2202	Plectin 6.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTCTTGCTTTCAGTACAGAAG	0.458													0	0	0	0.006999	0	38	52										T	7584100	C	T	7584100	3	4	93	1	0	0	0	0	1	0	0	0	4781	838	29	1	6699	1	DSP	6	7584100	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	5857376	7584100	163530967	112	27826										
HIST1H3B	8358	broad.mit.edu	37	chr6	26031997	26031997	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagccctaccaagtaggcctCacaagcctcctgcagcgcca	9	17	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:26031997C>T	uc003nfs.1	-	1	292	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						AAGTAGGCCTCACAAGCCTCC	0.567													0	0	0	0.008871	0	21	65										T	26031997	C	T	26031997	3	4	93	1	0	0	0	0	1	0	0	0	7156	835	29	1	122	1	HIST1H3B	6	26031997	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	18447897	26031997	145083070	113	27827										
HIST1H1C	3006	broad.mit.edu	37	chr6	26056393	26056393	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgcaccagagtgcccttgctCaccaggctcttgagaccaag	10	14	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:26056393C>T	uc003nfw.2	-	1	307	c.264G>A	c.(262-264)GTG>GTA	p.V88V		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	88	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TGCCCTTGCTCACCAGGCTCT	0.532													0	0	0	0.013726	0	34	129										T	26056393	C	T	26056393	2	4	93	1	0	0	0	0	0	0	0	1	7124	813	29	1		1	HIST1H1C	6	26056393	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	24396	26056393	145058674	114	27828										
BTN1A1	696	broad.mit.edu	37	chr6	26501534	26501534	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gatggcagttttcccaagctCcggtctccccagatgtctgc	10	14	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:26501534C>G	uc003nif.3	+	1	40	c.20C>G	c.(19-21)TCC>TGC	p.S7C		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	7						extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						TTCCCAAGCTCCGGTCTCCCC	0.522													0	0	0	0.010771	0	40	55										G	26501534	C	G	26501534	3	3	93	1	0	0	0	0	1	0	0	0	1559	855	30	1	22	1	BTN1A1	6	26501534	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	445141	26501534	144613533	115	27829										
HSPA1A	3303	broad.mit.edu	37	chr6	31783561	31783561	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aagccgcggcgatcggcatcGacctgggcaccacctactcc	11	17	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:31783561G>A	uc003nxj.2	+	1	271	c.28G>A	c.(28-30)GAC>AAC	p.D10N	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc011doj.1_Missense_Mutation_p.D10N|HSPA1A_uc003nxi.1_Missense_Mutation_p.D10N|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	10					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						GATCGGCATCGACCTGGGCAC	0.647													0	0	0	0.01441	0	40	34										A	31783561	G	A	31783561	3	1	93	1	0	0	0	0	1	0	0	0	7408	1058	37	1	30	1	HSPA1A	6	31783561	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5282027	31783561	139331506	116	27830										
HLA-DQA1	3117	broad.mit.edu	37	chr6	32609935	32609935	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagtgatcattccttcttcaAgatcagttacctcaccttcc	5	13	5	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:32609935A>G	uc003obr.2	+	3	571	c.518A>G	c.(517-519)AAG>AGG	p.K173R	HLA-DQA1_uc003obs.2_RNA|HLA-DQA1_uc003obt.1_Missense_Mutation_p.K173R|HLA-DQA1_uc003obu.2_5'Flank	NM_002122	NP_002113	P01909	DQA1_HUMAN	major histocompatibility complex, class II, DQ	172	Ig-like C1-type.|Alpha-2.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						TCCTTCTTCAAGATCAGTTAC	0.512													0	0	0	0.012319	0	18	67										G	32609935	A	G	32609935	3	3	93	1	0	0	0	0	1	0	0	0	7204	72	3	5	528	5	HLA-DQA1	6	32609935	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	826374	32609935	138505132	117	27831										
HLA-DQA2	3118	broad.mit.edu	37	chr6	32713754	32713754	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagtgatcattccttcttcaAgatcagttacctcaccttcc	5	13	5	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:32713754A>G	uc003obx.2	+	3	576	c.518A>G	c.(517-519)AAG>AGG	p.K173R		NM_020056	NP_064440	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ	173	Alpha-2.|Extracellular (Potential).|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCTTCTTCAAGATCAGTTAC	0.517													0	0	0	0.007291	0	26	182										G	32713754	A	G	32713754	3	3	93	1	0	0	0	0	1	0	0	0	7205	72	3	5	528	5	HLA-DQA2	6	32713754	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	103819	32713754	138401313	118	27832										
ZBTB9	221504	broad.mit.edu	37	chr6	33423781	33423781	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agatatcaggaagcggaactCagcctggaggagcaaaggag	15	7	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:33423781C>T	uc003oeq.2	+	2	1172	c.904C>T	c.(904-906)CAG>TAG	p.Q302*		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	302	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGCGGAACTCAGCCTGGAGG	0.547													0	0	0	0.003954	0	26	61										T	33423781	C	T	33423781	4	4	93	1	0	0	0	0	0	1	0	0	17555	827	29	1	906	1	ZBTB9	6	33423781	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	710027	33423781	137691286	119	27833										
CCND3	896	broad.mit.edu	37	chr6	41908144	41908144	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagacagcgtggtcggtgtaGatgcacagtttttcgatggt	15	6	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:41908144G>C	uc003orn.2	-	2	543	c.378C>G	c.(376-378)ATC>ATG	p.I126M	CCND3_uc003orp.2_Missense_Mutation_p.I45M|CCND3_uc011duk.1_Intron|CCND3_uc011dum.1_Missense_Mutation_p.I45M|CCND3_uc003orm.2_Missense_Mutation_p.I76M|CCND3_uc003oro.2_Intron|CCND3_uc011dul.1_Intron	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	126	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGTCGGTGTAGATGCACAGTT	0.617			T	IGH@	MM								0	0	0	0.00632	0	27	78										C	41908144	G	C	41908144	3	2	93	1	0	0	0	0	1	0	0	0	2918	932	33	1	516	1	CCND3	6	41908144	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	8484363	41908144	129206923	120	27834										
BEND6	221336	broad.mit.edu	37	chr6	56880031	56880031	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acatctgcatccaccctctgGagagcaacaaacaactcctc	5	16	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:56880031G>A	uc010kab.2	+	4	985	c.399G>A	c.(397-399)TGG>TGA	p.W133*	BEND6_uc003pdi.3_Nonsense_Mutation_p.W35*	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	133											0						CCACCCTCTGGAGAGCAACAA	0.478													0	0	0	0.007291	0	31	49										A	56880031	G	A	56880031	4	1	93	1	0	0	0	0	0	1	0	0	1402	1183	41	1	409	1	BEND6	6	56880031	Nonsense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	14971887	56880031	114235036	121	27835										
OGFRL1	79627	broad.mit.edu	37	chr6	72011597	72011597	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagagaaggacagtaatgctGagaacatgaattctcaacct	9	8	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:72011597G>C	uc003pfx.1	+	7	1364	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	401						membrane	receptor activity				0						CAGTAATGCTGAGAACATGAA	0.458													0	0	0	0.007291	0	28	42										C	72011597	G	C	72011597	3	2	93	1	0	0	0	0	1	0	0	0	10844	1291	45	1	1227	1	OGFRL1	6	72011597	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	15131566	72011597	99103470	122	27836										
HACE1	57531	broad.mit.edu	37	chr6	105198288	105198288	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aagccctgtaaaaaagcattGatctgaggctgaatggctct	10	8	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:105198288G>C	uc003pqu.1	-	20	2548	c.2271C>G	c.(2269-2271)ATC>ATG	p.I757M	HACE1_uc010kcy.1_Missense_Mutation_p.I239M|HACE1_uc010kcz.1_Missense_Mutation_p.I542M|HACE1_uc010kcx.1_Missense_Mutation_p.I166M|HACE1_uc003pqt.1_Missense_Mutation_p.I410M	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	757	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		AAAAAGCATTGATCTGAGGCT	0.383													0	0	0	0.000602	0	4	18										C	105198288	G	C	105198288	3	2	93	1	0	0	0	0	1	0	0	0	6940	1280	45	1	478	1	HACE1	6	105198288	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	33186691	105198288	65916779	123	27837										
UTRN	7402	broad.mit.edu	37	chr6	144860468	144860468	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gaagtacatgctgaaaaactCaaatggctgaatagaactga	9	6	1	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:144860468C>G	uc003qkt.2	+	44	6500	c.6408C>G	c.(6406-6408)CTC>CTG	p.L2136L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2136					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTGAAAAACTCAAATGGCTGA	0.348													0	0	0	0.013537	0	13	32										G	144860468	C	G	144860468	2	3	93	1	0	0	0	0	0	0	0	1	17100	813	29	1		1	UTRN	6	144860468	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	39662180	144860468	26254599	124	27838										
KATNA1	11104	broad.mit.edu	37	chr6	149959681	149959681	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcactaatcataagaagactCatgttcaactgtaagctaaa	5	8	4	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:149959681C>G	uc003qmr.1	-	1	48	c.3G>C	c.(1-3)ATG>ATC	p.M1I	KATNA1_uc003qms.2_Missense_Mutation_p.M1I|KATNA1_uc003qmt.2_Missense_Mutation_p.M1I|KATNA1_uc011eed.1_Missense_Mutation_p.M1I	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	1	Interaction with microtubule.|Interaction with KATNB1.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		TAAGAAGACTCATGTTCAACT	0.333													0	0	0	0.005443	0	27	124										G	149959681	C	G	149959681	3	3	93	1	0	0	0	0	1	0	0	0	7984	826	29	1	1512	1	KATNA1	6	149959681	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	5099213	149959681	21155386	125	27839										
NUP43	348995	broad.mit.edu	37	chr6	150048189	150048189	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctaaaacatccaaagtgttCacagacagagacctactggg	8	11	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr6:150048189C>T	uc003qmz.2	-	8	1116	c.1059G>A	c.(1057-1059)GTG>GTA	p.V353V	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Silent_p.V257V	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	353					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		CCAAAGTGTTCACAGACAGAG	0.398													0	0	0	0.00333	0	23	21										T	150048189	C	T	150048189	2	4	93	1	0	0	0	0	0	0	0	1	10765	813	29	1		1	NUP43	6	150048189	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	88508	150048189	21066878	126	27840										
C7orf28B	221960	broad.mit.edu	37	chr7	6840699	6840699	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cacaatgatctcctcatcttCatccactctgcaagacgagg	6	14	5	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:6840699C>T	uc003sqx.1	-	14	1306	c.1273G>A	c.(1273-1275)GAA>AAA	p.E425K	C7orf28B_uc011jxd.1_Missense_Mutation_p.E282K	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960	425						lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		TCCTCATCTTCATCCACTCTG	0.438													0	0	0	0.004878	0	20	82										T	6840699	C	T	6840699	3	4	93	1	0	0	0	0	1	0	0	0	2384	835	29	1	183	1	C7orf28B	7	6840699	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		6840699	152297964	127	27841										
RPA3	6119	broad.mit.edu	37	chr7	7678736	7678736	+	Missense_Mutation	SNP	C	C	T													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gatggttccattttttccttCtccatctgaaagaataaaca							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:7678736C>T	uc003sri.2	-	6	1311	c.139G>A	c.(139-141)GAA>AAA	p.E47K	RPA3_uc003srh.2_Missense_Mutation_p.E8K	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	47					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		TTTTTTCCTTCTCCATCTGAA	0.299								Direct_reversal_of_damage|NER					0	0	0	0.004482	0	7	39										T	7678736	C	T	7678736	3	4	93	1	0	0	0	0	1	0	0	0	13538	922	32	1	238	1	RPA3	7	7678736	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	838037	7678736	151459927	128	27842	138	2								
RPA3	6119	broad.mit.edu	37	chr7	7678739	7678739	+	Nonsense_Mutation	SNP	C	C	A													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggttccattttttccttctcCatctgaaagaataaacattt							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:7678739C>A	uc003sri.2	-	6	1308	c.136G>T	c.(136-138)GGA>TGA	p.G46*	RPA3_uc003srh.2_Nonsense_Mutation_p.G7*	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	46					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		TTTCCTTCTCCATCTGAAAGA	0.299								Direct_reversal_of_damage|NER					1	0	1.06961e-07	0.00308	1.1241e-07	6	39										A	7678739	C	A	7678739	4	1	93	1	0	0	0	0	0	1	0	0	13538	603	21	4	241	4	RPA3	7	7678739	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3	7678739	151459924	129	27843	138	2								
C7orf30	115416	broad.mit.edu	37	chr7	23347497	23347497	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctttttgcagtacaaacaccTgaaatgtaaacgtgaccctc	6	11	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:23347497T>C	uc003swd.1	+	3	478	c.446T>C	c.(445-447)CTG>CCG	p.L149P	C7orf30_uc003swe.2_5'Flank	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	149						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			TACAAACACCTGAAATGTAAA	0.418													0	0	0	0.004672	0	3	79										C	23347497	T	C	23347497	3	2	93	1	0	0	0	0	1	0	0	0	2386	1580	55	5	456	5	C7orf30	7	23347497	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	15668758	23347497	135791166	130	27844										
HOXA3	3200	broad.mit.edu	37	chr7	27148001	27148005	+	Frame_Shift_Del	DEL	ACGGG	ACGGG	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cgggggcgactggggctcatAcgggacgctgttgaccagcg							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:27148001_27148005delACGGG	uc011jzl.1	-	3	1061_1065	c.861_865delCCCGT	c.(859-867)GTCCCGTATfs	p.V287fs	HOXA3_uc011jzk.1_Frame_Shift_Del_p.V129fs|HOXA3_uc003syk.2_Frame_Shift_Del_p.V287fs	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	287_289					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						TGGGGCTCATACGGGACGCTGTTGA	0.693																		27	57	---	---								-	27148005	ACGGG	-	27148001	7	5	93	1	0	1	0	1	0	0	0	0	7293	391	14	0	470	0	HOXA3	7	27148001	Frame_Shift_Del	DEL	ACGGG	TCGA-G2-A2EF-01A-12D-A18F-08	3800504	27148001	131990662	131	27845										
AVL9	23080	broad.mit.edu	37	chr7	32598734	32598734	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	catggagaagatgctgccatGaagactgaggagcctttgtt	13	7	0	5			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:32598734G>A	uc003tcv.1	+	10	1019	c.873G>A	c.(871-873)ATG>ATA	p.M291I	AVL9_uc011kai.1_Missense_Mutation_p.M291I|AVL9_uc010kwj.1_Missense_Mutation_p.M132I	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	291						integral to membrane					0						ATGCTGCCATGAAGACTGAGG	0.463													0	0	0	0.010729	0	10	18										A	32598734	G	A	32598734	3	1	93	1	0	0	0	0	1	0	0	0	1228	1290	45	1	911	1	AVL9	7	32598734	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5450733	32598734	126539929	132	27846										
RP9	6100	broad.mit.edu	37	chr7	33136118	33136118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acctcaccttacgtccttttCatgtcgtttattgtctcgta	5	12	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:33136118C>G	uc003tdm.2	-	5	472	c.454G>C	c.(454-456)GAA>CAA	p.E152Q		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9	152	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)			ACGTCCTTTTCATGTCGTTTA	0.383													0	0	0	0.013537	0	11	41										G	33136118	C	G	33136118	3	3	93	1	0	0	0	0	1	0	0	0	13535	835	29	1	219	1	RP9	7	33136118	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	537384	33136118	126002545	133	27847										
ABCA13	154664	broad.mit.edu	37	chr7	48318168	48318168	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctaacggatttgcttttcttTataaataattcattccctct	3	9	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:48318168T>C	uc003toq.2	+	18	7402	c.7377T>C	c.(7375-7377)TTT>TTC	p.F2459F	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2459					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGCTTTTCTTTATAAATAATT	0.343													0	0	0	0.01441	0	48	79										C	48318168	T	C	48318168	2	2	93	1	0	0	0	0	0	0	0	1	31	1751	61	5		5	ABCA13	7	48318168	Silent	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	15182050	48318168	110820495	134	27848										
POM121L12	285877	broad.mit.edu	37	chr7	53103750	53103750	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggggctgtgtcgtgcctggaAcccaggacggacctggagcc	17	12	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:53103750A>G	uc003tpz.2	+	1	402	c.386A>G	c.(385-387)AAC>AGC	p.N129S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	129											0						CGTGCCTGGAACCCAGGACGG	0.642													0	0	0	0.00333	0	20	33										G	53103750	A	G	53103750	3	3	93	1	0	0	0	0	1	0	0	0	12241	43	2	5	388	5	POM121L12	7	53103750	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	4785582	53103750	106034913	135	27849										
ZNF479	90827	broad.mit.edu	37	chr7	57188660	57188660	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttatgagtctgaaatattttGttttgggtagttgacaaaca	9	3	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:57188660G>A	uc010kzo.2	-	5	733	c.462C>T	c.(460-462)AAC>AAT	p.N154N		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			GAAATATTTTGTTTTGGGTAG	0.289													0	0	0	0.003954	0	21	49										A	57188660	G	A	57188660	2	1	93	1	0	0	0	0	0	0	0	1	17930	1368	48	2		2	ZNF479	7	57188660	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4084910	57188660	101950003	136	27850										
WBSCR28	135886	broad.mit.edu	37	chr7	73275587	73275587	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctgttgcaggttacgaggctCtcagtgctggtgagtggggg	18	7	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:73275587C>G	uc003tzk.2	+	1	99	c.63C>G	c.(61-63)CTC>CTG	p.L21L	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	21						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				TTACGAGGCTCTCAGTGCTGG	0.642													0	0	0	0.010729	0	12	20										G	73275587	C	G	73275587	2	3	93	1	0	0	0	0	0	0	0	1	17264	900	32	1		1	WBSCR28	7	73275587	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	16086927	73275587	85863076	137	27851										
HGF	3082	broad.mit.edu	37	chr7	81355231	81355231	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccatgtgacatatcacagttTggaatttgggagcagtagcc	11	8	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:81355231T>C	uc003uhl.2	-	9	1308	c.1143A>G	c.(1141-1143)CCA>CCG	p.P381P	HGF_uc003uhm.2_Silent_p.P376P	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	381	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TATCACAGTTTGGAATTTGGG	0.448													0	0	0	0.00245	0	14	79										C	81355231	T	C	81355231	2	2	93	1	0	0	0	0	0	0	0	1	7085	1799	63	5		5	HGF	7	81355231	Silent	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	8079644	81355231	77783432	138	27852										
CROT	54677	broad.mit.edu	37	chr7	86988563	86988563	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aagaatataagaaaactgaaGaaatagttcaaaaatttcaa	5	3	2	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:86988563G>A	uc003uit.2	+	4	402	c.157G>A	c.(157-159)GAA>AAA	p.E53K	CROT_uc003uis.3_Missense_Mutation_p.E53K|CROT_uc003uiu.2_Missense_Mutation_p.E81K	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	53					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	GAAAACTGAAGAAATAGTTCA	0.308													0	0	0	0.00308	0	8	41										A	86988563	G	A	86988563	3	1	93	1	0	0	0	0	1	0	0	0	3894	943	33	1	251	1	CROT	7	86988563	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5633332	86988563	72150100	139	27853										
AKAP9	10142	broad.mit.edu	37	chr7	91631551	91631551	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aagaaaaatttgcacaacttGaagcagagaatagcattctt	7	6	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:91631551G>A	uc003ulg.2	+	8	2545	c.2320G>A	c.(2320-2322)GAA>AAA	p.E774K	AKAP9_uc003ule.2_Missense_Mutation_p.E786K|AKAP9_uc003ulf.2_Missense_Mutation_p.E774K|AKAP9_uc003uli.2_Missense_Mutation_p.E399K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	786	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGCACAACTTGAAGCAGAGAA	0.303			T	BRAF	papillary thyroid								0	0	0	0.013537	0	12	68										A	91631551	G	A	91631551	3	1	93	1	0	0	0	0	1	0	0	0	459	1291	45	1	2350	1	AKAP9	7	91631551	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4642988	91631551	67507112	140	27854										
CYP3A7	1551	broad.mit.edu	37	chr7	99312307	99312307	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtaaggaatggaaagacttcTgtagaaaaaaaaaaccaaca	8	5	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:99312307T>C	uc003uru.2	-	8	776	c.671_splice	c.e8-1	p.K224_splice	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GAAAGACTTCTGTAGAAAAAA	0.303													0	0	0	0.003954	0	25	54										C	99312307	T	C	99312307	5	2	93	1	0	0	0	0	0	0	1	0	4181	1594	55	5	866	5	CYP3A7	7	99312307	Splice_Site	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	7680756	99312307	59826356	141	27855										
GIGYF1	64599	broad.mit.edu	37	chr7	100285422	100285422	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cggtcccacctgttcctcctCagtcagcggctccagagcca	9	18	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:100285422C>T	uc003uwg.1	-	3	1259	c.250G>A	c.(250-252)GAG>AAG	p.E84K		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	84										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGTTCCTCCTCAGTCAGCGGC	0.687													0	0	0	0.005443	0	23	62										T	100285422	C	T	100285422	3	4	93	1	0	0	0	0	1	0	0	0	6377	835	29	1	2945	1	GIGYF1	7	100285422	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	973115	100285422	58853241	142	27856										
RELN	5649	broad.mit.edu	37	chr7	103194142	103194142	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gaatatggacaataaagaccGatgttaccaccaggatagaa	9	7	0	2	rs141509094		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:103194142G>C	uc003vca.2	-	39	6094	c.5934C>G	c.(5932-5934)ATC>ATG	p.I1978M	RELN_uc010liz.2_Missense_Mutation_p.I1978M	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1978					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AATAAAGACCGATGTTACCAC	0.363													0	0	0	0.003163	0	14	24										C	103194142	G	C	103194142	3	2	93	1	0	0	0	0	1	0	0	0	13220	1048	37	1	4556	1	RELN	7	103194142	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2908720	103194142	55944521	143	27857										
PTN	5764	broad.mit.edu	37	chr7	136935980	136935980	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	taatggcaaggacttaccttGaggtttgggcttggtcagtt	13	6	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:136935980G>A	uc003vtq.2	-	4	811	c.448C>T	c.(448-450)CAA>TAA	p.Q150*	PTN_uc010lmx.2_Nonsense_Mutation_p.Q150*|PTN_uc003vtr.1_Nonsense_Mutation_p.Q150*	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	150					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2						GACTTACCTTGAGGTTTGGGC	0.458													0	0	0	0.01441	0	45	125										A	136935980	G	A	136935980	4	1	93	1	0	0	0	0	0	1	0	0	12768	1299	45	1	66	1	PTN	7	136935980	Nonsense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	33741838	136935980	22202683	144	27858										
DENND2A	27147	broad.mit.edu	37	chr7	140301532	140301532	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggggtgggctccctgccttcCaggtccgaggggtggaccct	17	13	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:140301532C>T	uc010lnj.2	-	1	811	c.666G>A	c.(664-666)CTG>CTA	p.L222L	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.L222L|DENND2A_uc003vvw.2_Silent_p.L222L|DENND2A_uc003vvx.2_Silent_p.L222L	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	222										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CCCTGCCTTCCAGGTCCGAGG	0.637													0	0	0	0.01441	0	50	130										T	140301532	C	T	140301532	2	4	93	1	0	0	0	0	0	0	0	1	4429	581	21	2		2	DENND2A	7	140301532	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3365552	140301532	18837131	145	27859										
SSPO	23145	broad.mit.edu	37	chr7	149476138	149476138	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgacttcatggagccaggcgGagggctggccatgttagcag	16	9	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr7:149476138G>C	uc010lpk.2	+	8	1016	c.1016G>C	c.(1015-1017)GGA>GCA	p.G339A	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	339	VWFD 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GAGCCAGGCGGAGGGCTGGCC	0.637													0	0	0	0.013537	0	12	23										C	149476138	G	C	149476138	3	2	93	1	0	0	0	0	1	0	0	0	15188	1174	41	1	1046	1	SSPO	7	149476138	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	9174606	149476138	9662525	146	27860										
RP1L1	94137	broad.mit.edu	37	chr8	10466760	10466760	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtccgctcagagaaggccgaGaggtttcgcaggccccggag	16	12	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:10466760G>A	uc003wtc.2	-	4	5077	c.4848C>T	c.(4846-4848)CTC>CTT	p.L1616L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1616					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGAAGGCCGAGAGGTTTCGCA	0.706													0	0	0	0.001855	0	13	12										A	10466760	G	A	10466760	2	1	93	1	0	0	0	0	0	0	0	1	13533	929	33	1		1	RP1L1	8	10466760	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		10466760	135897262	147	27861										
PCM1	5108	broad.mit.edu	37	chr8	17813004	17813004	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccacaaaggagtgtcgatcaGagaagtacttcagctccctc	9	12	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:17813004G>C	uc003wyi.3	+	10	1736	c.1314G>C	c.(1312-1314)CAG>CAC	p.Q438H	PCM1_uc011kyh.1_Missense_Mutation_p.Q438H|PCM1_uc003wyj.3_Missense_Mutation_p.Q438H|PCM1_uc003wyh.2_Missense_Mutation_p.Q477H|PCM1_uc010lta.1_Missense_Mutation_p.Q477H	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	438					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		GTGTCGATCAGAGAAGTACTT	0.433			T	RET|JAK2	papillary thyroid|CML|MPD								0	0	0	0.001168	0	6	6										C	17813004	G	C	17813004	3	2	93	1	0	0	0	0	1	0	0	0	11584	933	33	1	1344	1	PCM1	8	17813004	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	7346244	17813004	128551018	148	27862										
SULF1	23213	broad.mit.edu	37	chr8	70536366	70536366	+	Frame_Shift_Del	DEL	G	G	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggcttccagtggtggcaacaGgggcaggatgctggcagata							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:70536366delG	uc010lza.1	+	15	2501	c.1784delG	c.(1783-1785)AGGfs	p.R595fs	SULF1_uc003xyd.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xye.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xyf.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xyg.2_Frame_Shift_Del_p.R595fs|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	595					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GGTGGCAACAGGGGCAGGATG	0.512																		9	20	---	---								-	70536366	G	-	70536366	7	5	93	1	0	1	0	1	0	0	0	0	15369	1000	35	0	1826	0	SULF1	8	70536366	Frame_Shift_Del	DEL	G	TCGA-G2-A2EF-01A-12D-A18F-08	52723362	70536366	75827656	149	27863										
TRPA1	8989	broad.mit.edu	37	chr8	72987642	72987642	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atcttcctcaggctgcgcttCattgaccccaccccggacgc	8	18	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:72987642C>T	uc003xza.2	-	1	178	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	1	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GGCTGCGCTTCATTGACCCCA	0.657													0	0	0	0.01441	0	49	54										T	72987642	C	T	72987642	3	4	93	1	0	0	0	0	1	0	0	0	16574	826	29	1	3464	1	TRPA1	8	72987642	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2451276	72987642	73376380	150	27864										
COL14A1	7373	broad.mit.edu	37	chr8	121170472	121170472	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtggttacaaacttcttgtGactccaacttcaggtaaaaa	8	8	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:121170472G>A	uc003yox.2	+	3	457	c.192G>A	c.(190-192)GTG>GTA	p.V64V		NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	64	Fibronectin type-III 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			AACTTCTTGTGACTCCAACTT	0.368													0	0	0	0.004482	0	8	42										A	121170472	G	A	121170472	2	1	93	1	0	0	0	0	0	0	0	1	3671	1277	45	1		1	COL14A1	8	121170472	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	48182830	121170472	25193550	151	27865										
FER1L6	654463	broad.mit.edu	37	chr8	125035748	125035748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	caacaggagagtggcctatgCccgcatcgcctccaaagacc	10	15	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:125035748C>T	uc003yqw.2	+	18	2404	c.2198C>T	c.(2197-2199)GCC>GTC	p.A733V	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	733	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTGGCCTATGCCCGCATCGCC	0.527													0	0	0	0.001168	0	4	100										T	125035748	C	T	125035748	3	4	93	1	0	0	0	0	1	0	0	0	5815	739	26	2	2264	2	FER1L6	8	125035748	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3865276	125035748	21328274	152	27866										
TG	7038	broad.mit.edu	37	chr8	134145801	134145801	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtaccccgtgctggtggagaGaactacaaggagttcagtga	14	8	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:134145801G>C	uc003ytw.2	+	47	8126	c.8085G>C	c.(8083-8085)GAG>GAC	p.E2695D	TG_uc010mdw.2_Missense_Mutation_p.E1454D|TG_uc011ljb.1_Missense_Mutation_p.E1064D|TG_uc011ljc.1_Missense_Mutation_p.E828D	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2695					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGGTGGAGAGAACTACAAGG	0.522													0	0	0	0.003755	0	37	54										C	134145801	G	C	134145801	3	2	93	1	0	0	0	0	1	0	0	0	15810	933	33	1	8271	1	TG	8	134145801	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	9110053	134145801	12218221	153	27867										
SLC45A4	57210	broad.mit.edu	37	chr8	142228412	142228412	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gatcagcaccacggcgttggCgcgccggtagcggtagcagt	16	12	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:142228412C>T	uc003ywd.1	-	4	1482	c.1174G>A	c.(1174-1176)GCC>ACC	p.A392T	SLC45A4_uc003ywc.1_Missense_Mutation_p.A392T|SLC45A4_uc010meq.1_Missense_Mutation_p.A390T	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	443					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			ACGGCGTTGGCGCGCCGGTAG	0.692													0	0	0	0.000602	0	5	68										T	142228412	C	T	142228412	3	4	93	1	0	0	0	0	1	0	0	0	14643	768	27	2	1242	2	SLC45A4	8	142228412	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	8082611	142228412	4135610	154	27868										
BAI1	575	broad.mit.edu	37	chr8	143603352	143603352	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgcacgctggtggccgccttCctgcacttcttcttcctgtc	9	16	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:143603352C>T	uc003ywm.2	+	20	3234	c.3051C>T	c.(3049-3051)TTC>TTT	p.F1017F		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1017	Helical; Name=3; (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGGCCGCCTTCCTGCACTTCT	0.687													0	0	0	0.004672	0	3	14										T	143603352	C	T	143603352	2	4	93	1	0	0	0	0	0	0	0	1	1298	854	30	1		1	BAI1	8	143603352	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1374940	143603352	2760670	155	27869										
ZNF251	90987	broad.mit.edu	37	chr8	145947781	145947781	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtgtgaatccttacgtgttCagtaagatgagagttaaaac	10	5	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr8:145947781C>T	uc003zdv.3	-	5	1520	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	422	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CTTACGTGTTCAGTAAGATGA	0.448													0	0	0	0.01441	0	58	68										T	145947781	C	T	145947781	3	4	93	1	0	0	0	0	1	0	0	0	17793	835	29	1	755	1	ZNF251	8	145947781	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2344429	145947781	416241	156	27870										
RANBP6	26953	broad.mit.edu	37	chr9	6015339	6015339	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	catctctctgaacatcagcaGgcagatttggataaacctcc	7	12	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:6015339G>C	uc003zjr.2	-	1	280	c.269C>G	c.(268-270)CCT>CGT	p.P90R	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	90					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		AACATCAGCAGGCAGATTTGG	0.433													0	0	0	0.00874	0	41	97										C	6015339	G	C	6015339	3	2	93	1	0	0	0	0	1	0	0	0	13031	1000	35	4	3052	4	RANBP6	9	6015339	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		6015339	135198092	157	27871										
DENND4C	55667	broad.mit.edu	37	chr9	19324474	19324474	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtaagtgataaagatactgGattagcattttttgatgact	9	3	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:19324474G>A	uc003znq.2	+	9	1247	c.1214G>A	c.(1213-1215)GGA>GAA	p.G405E	DENND4C_uc011lnc.1_Intron	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	405						integral to membrane				ovary(1)|skin(1)	2						AAAGATACTGGATTAGCATTT	0.303													0	0	0	0.01441	0	83	251										A	19324474	G	A	19324474	3	1	93	1	0	0	0	0	1	0	0	0	4435	1174	41	1	1248	1	DENND4C	9	19324474	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	13309135	19324474	121888957	158	27872										
FOXB2	442425	broad.mit.edu	37	chr9	79634833	79634833	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tggcaagggtagcttctgggCgctgcaccccgactgcgggg	17	12	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:79634833C>T	uc004ako.1	+	1	263	c.263C>T	c.(262-264)GCG>GTG	p.A88V		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	88	Fork-head.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						AGCTTCTGGGCGCTGCACCCC	0.642													0	0	0	0.01441	0	55	14										T	79634833	C	T	79634833	3	4	93	1	0	0	0	0	1	0	0	0	5993	768	27	2	265	2	FOXB2	9	79634833	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	60310359	79634833	61578598	159	27873										
PTCH1	5727	broad.mit.edu	37	chr9	98229643	98229643	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccgtaaggtccagcccgtctCtcactcgggtggtgccataa	11	14	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:98229643C>T	uc004avk.3	-	15	2503	c.2315G>A	c.(2314-2316)AGA>AAA	p.R772K	PTCH1_uc010mro.2_Missense_Mutation_p.R621K|PTCH1_uc010mrp.2_Missense_Mutation_p.R621K|PTCH1_uc010mrq.2_Missense_Mutation_p.R621K|PTCH1_uc004avl.3_Missense_Mutation_p.R621K|PTCH1_uc010mrr.2_Missense_Mutation_p.R706K|PTCH1_uc004avm.3_Missense_Mutation_p.R771K	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	772	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CAGCCCGTCTCTCACTCGGGT	0.478									Basal_Cell_Nevus_syndrome				0	0	0	0.011902	0	43	16										T	98229643	C	T	98229643	3	4	93	1	0	0	0	0	1	0	0	0	12730	913	32	1	2064	1	PTCH1	9	98229643	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	18594810	98229643	42983788	160	27874										
RXRA	6256	broad.mit.edu	37	chr9	137293649	137293649	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	catgggcccgcctttctcggTcatcagctcccccatgggcc	10	18	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr9:137293649T>C	uc004cfb.2	+	2	362	c.200T>C	c.(199-201)GTC>GCC	p.V67A	RXRA_uc004cfa.1_Silent_p.G117G	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	67	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCTTTCTCGGTCATCAGCTCC	0.642													0	0	0	0.004672	0	3	117										C	137293649	T	C	137293649	3	2	93	1	0	0	0	0	1	0	0	0	13763	1667	58	5	206	5	RXRA	9	137293649	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	39064006	137293649	3919782	161	27875										
FBXO18	84893	broad.mit.edu	37	chr10	5955750	5955750	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	attgcctatatcttcaggagAattcctgcactcaggccaca	7	12	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:5955750A>T	uc001iis.2	+	7	1347	c.1252A>T	c.(1252-1254)AAT>TAT	p.N418Y	FBXO18_uc001iir.2_Missense_Mutation_p.N344Y|FBXO18_uc009xig.2_Missense_Mutation_p.N344Y|FBXO18_uc001iit.2_Missense_Mutation_p.N469Y	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	418					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TCTTCAGGAGAATTCCTGCAC	0.398													0	0	0	0.001168	0	5	69										T	5955750	A	T	5955750	3	4	93	1	0	0	0	0	1	0	0	0	5731	246	9	5	1440	5	FBXO18	10	5955750	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08		5955750	129578997	162	27876										
PFKFB3	5209	broad.mit.edu	37	chr10	6258137	6258137	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcaaaagctacctggcgaaaGaagggggacaaattgcggta	13	7	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:6258137G>T	uc001ije.2	+	4	733	c.349G>T	c.(349-351)GAA>TAA	p.E117*	PFKFB3_uc001ijd.2_Nonsense_Mutation_p.E97*|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Nonsense_Mutation_p.E131*|PFKFB3_uc001ijf.2_Nonsense_Mutation_p.E117*	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	117	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						CCTGGCGAAAGAAGGGGGACA	0.587													1	0	8.20599e-20	0.011902	8.81301e-20	41	51										T	6258137	G	T	6258137	4	4	93	1	0	0	0	0	0	1	0	0	11762	943	33	3	383	3	PFKFB3	10	6258137	Nonsense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	302387	6258137	129276610	163	27877										
SUV39H2	79723	broad.mit.edu	37	chr10	14939477	14939477	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtgtaaagacccttgtgaaGattaaaagaatgagttttgt	11	3	0	5			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:14939477G>A	uc001inh.2	+	2	686	c.630G>A	c.(628-630)AAG>AAA	p.K210K	SUV39H2_uc001ing.2_Intron|SUV39H2_uc001ini.2_Silent_p.K210K|SUV39H2_uc001inj.2_Silent_p.K210K	NM_024670	NP_078946	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2	270	SET.				cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|ovary(1)	3						CCCTTGTGAAGATTAAAAGAA	0.388													0	0	0	0.001855	0	12	37										A	14939477	G	A	14939477	2	1	93	1	0	0	0	0	0	0	0	1	15410	933	33	1		1	SUV39H2	10	14939477	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	8681340	14939477	120595270	164	27878										
NMT2	9397	broad.mit.edu	37	chr10	15174885	15174885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gttttttatttgaagacactCtgaccccacagtgccactgc	7	12	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:15174885C>G	uc001inz.1	-	6	734	c.650G>C	c.(649-651)AGA>ACA	p.R217T	NMT2_uc001ioa.1_Missense_Mutation_p.R204T|NMT2_uc009xjo.1_Missense_Mutation_p.R217T|NMT2_uc010qbz.1_Missense_Mutation_p.R29T	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	217					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						TGAAGACACTCTGACCCCACA	0.493													0	0	0	0.003163	0	16	55										G	15174885	C	G	15174885	3	3	93	1	0	0	0	0	1	0	0	0	10504	913	32	1	874	1	NMT2	10	15174885	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	235408	15174885	120359862	165	27879										
LRRTM3	347731	broad.mit.edu	37	chr10	68686706	68686706	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtaattaggctactgagcgGatcagctgtagcactggtta	12	7	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:68686706G>A	uc001jmz.1	+	2	582	c.32G>A	c.(31-33)GGA>GAA	p.G11E	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Missense_Mutation_p.G11E	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	11						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CTACTGAGCGGATCAGCTGTA	0.418													0	0	0	0.004007	0	13	29										A	68686706	G	A	68686706	3	1	93	1	0	0	0	0	1	0	0	0	9041	1174	41	1	38	1	LRRTM3	10	68686706	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	53511821	68686706	66848041	166	27880										
POLR3A	11128	broad.mit.edu	37	chr10	79740028	79740028	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctagtgatgcccaggacttCaccctgcgtcaagggagaaa	11	12	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:79740028C>A	uc001jzn.2	-	30	3989	c.3895G>T	c.(3895-3897)GAA>TAA	p.E1299*		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1299					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CCCAGGACTTCACCCTGCGTC	0.517													1	0	1.15088e-07	0.004007	1.20305e-07	16	22										A	79740028	C	A	79740028	4	1	93	1	0	0	0	0	0	1	0	0	12228	835	29	3	285	3	POLR3A	10	79740028	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	11053322	79740028	55794719	167	27881										
POLR3A	11128	broad.mit.edu	37	chr10	79741314	79741314	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctcgatgcccagagttttctCcacctacagagagccagtaa	8	13	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:79741314C>T	uc001jzn.2	-	29	3857	c.3763G>A	c.(3763-3765)GAG>AAG	p.E1255K		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	1255					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AGAGTTTTCTCCACCTACAGA	0.542													0	0	0	0.01441	0	127	162										T	79741314	C	T	79741314	3	4	93	1	0	0	0	0	1	0	0	0	12228	864	30	1	421	1	POLR3A	10	79741314	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1286	79741314	55793433	168	27882										
SEC31B	25956	broad.mit.edu	37	chr10	102249108	102249108	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtagctcaggggtgaggctCataactggagcagtaattgg	15	6	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:102249108C>T	uc001krc.1	-	23	3174	c.3072G>A	c.(3070-3072)ATG>ATA	p.M1024I	SEC31B_uc010qpo.1_Missense_Mutation_p.M1023I|SEC31B_uc001krd.1_Missense_Mutation_p.M561I|SEC31B_uc001krf.1_Missense_Mutation_p.M456I|SEC31B_uc001kre.1_Missense_Mutation_p.M456I	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	1024	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GGGTGAGGCTCATAACTGGAG	0.537													0	0	0	0.014323	0	22	37										T	102249108	C	T	102249108	3	4	93	1	0	0	0	0	1	0	0	0	13999	826	29	1	483	1	SEC31B	10	102249108	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	22507794	102249108	33285639	169	27883										
BTBD16	118663	broad.mit.edu	37	chr10	124036305	124036305	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctttctttgattaccaagcaGcacaaagctcggctggaacg	9	11	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:124036305G>A	uc001lgc.1	+	3	270	c.19_splice	c.e3-1	p.H7_splice	BTBD16_uc001lgd.1_Silent_p.Q5Q	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16											skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTACCAAGCAGCACAAAGCTC	0.448													0	0	0	0.004672	0	3	97										A	124036305	G	A	124036305	5	1	93	1	0	0	0	0	0	0	1	0	1541	985	34	2	24	2	BTBD16	10	124036305	Splice_Site	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	21787197	124036305	11498442	170	27884										
MMP21	118856	broad.mit.edu	37	chr10	127464241	127464241	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctcctacctgagcagcgtgGaggtcggcaatgggcttggc	15	12	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:127464241G>C	uc001liu.2	-	1	150	c.150C>G	c.(148-150)CTC>CTG	p.L50L		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	50					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GAGCAGCGTGGAGGTCGGCAA	0.682													0	0	0	0.008361	0	28	28										C	127464241	G	C	127464241	2	2	93	1	0	0	0	0	0	0	0	1	9660	1161	41	1		1	MMP21	10	127464241	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3427936	127464241	8070506	171	27885										
DOCK1	1793	broad.mit.edu	37	chr10	129224163	129224163	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttttctggccgaagggatcaGaatccatggagacaaagtca	11	8	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:129224163G>A	uc001ljt.2	+	47	4803	c.4739G>A	c.(4738-4740)AGA>AAA	p.R1580K	DOCK1_uc010qun.1_Missense_Mutation_p.R1601K|DOCK1_uc009yaq.2_Missense_Mutation_p.R575K	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1580	DHR-2.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GAAGGGATCAGAATCCATGGA	0.493													0	0	0	0.005524	0	39	191										A	129224163	G	A	129224163	3	1	93	1	0	0	0	0	1	0	0	0	4684	942	33	1	4925	1	DOCK1	10	129224163	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1759922	129224163	6310584	172	27886										
BNIP3	664	broad.mit.edu	37	chr10	133786615	133786615	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atcttgtggtgtctgcgagcGaggtgggcttggcgatgtga	18	6	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr10:133786615G>A	uc001lkv.1	-	3	331	c.205C>T	c.(205-207)CGC>TGC	p.R69C	BNIP3_uc001lku.1_5'Flank|BNIP3_uc010qut.1_Missense_Mutation_p.R69C	NM_004052	NP_004043	Q12983	BNIP3_HUMAN	BCL2/adenovirus E1B 19kD-interacting protein 3	69					cellular response to cobalt ion|cellular response to hypoxia|cellular response to mechanical stimulus|chromatin remodeling|defense response to virus|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis|interspecies interaction between organisms|mitochondrial fragmentation involved in apoptosis|negative regulation of membrane potential|negative regulation of mitochondrial fusion|negative regulation of survival gene product expression|neuron apoptosis|positive regulation of mitochondrial fission|positive regulation of protein complex disassembly|positive regulation of release of cytochrome c from mitochondria|reactive oxygen species metabolic process|regulation of mitochondrial membrane permeability	dendrite|integral to mitochondrial outer membrane|nuclear envelope|nucleoplasm	GTPase binding|protein heterodimerization activity|protein homodimerization activity			lung(1)|skin(1)	2		all_cancers(35;4e-11)|all_epithelial(44;5.07e-08)|Ovarian(717;2.61e-05)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Breast(234;0.023)|all_neural(114;0.0299)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)		Epithelial(32;1.59e-12)|all cancers(32;3.75e-11)|OV - Ovarian serous cystadenocarcinoma(35;2.57e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GTCTGCGAGCGAGGTGGGCTT	0.468													0	0	0	0.006999	0	39	118										A	133786615	G	A	133786615	3	1	93	1	0	0	0	0	1	0	0	0	1478	1058	37	1	395	1	BNIP3	10	133786615	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4562452	133786615	1748132	173	27887										
MRGPRE	116534	broad.mit.edu	37	chr11	3249790	3249790	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccttgcagcaagtcggggacGatggccaccatgtggcagcc	14	13	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:3249790G>A	uc001lxq.3	-	2	547	c.237C>T	c.(235-237)ATC>ATT	p.I79I		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	79	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCGGGGACGATGGCCACCA	0.622													0	0	0	0.01441	0	62	31										A	3249790	G	A	3249790	2	1	93	1	0	0	0	0	0	0	0	1	9764	1048	37	1		1	MRGPRE	11	3249790	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		3249790	131756726	174	27888										
CHRNA10	57053	broad.mit.edu	37	chr11	3687403	3687403	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagaagaagatggccaggaaGaagcggtccatcacacgggc	15	9	1	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:3687403G>A	uc001lyf.2	-	5	1359	c.1287C>T	c.(1285-1287)TTC>TTT	p.F429F	CHRNA10_uc010qxt.1_Silent_p.F223F|CHRNA10_uc010qxu.1_Silent_p.F223F	NM_020402	NP_065135	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10	429	Helical; (Potential).				elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			ovary(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	TGGCCAGGAAGAAGCGGTCCA	0.627													0	0	0	0.01441	0	49	20										A	3687403	G	A	3687403	2	1	93	1	0	0	0	0	0	0	0	1	3382	933	33	1		1	CHRNA10	11	3687403	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	437613	3687403	131319113	175	27889										
OR52B4	143496	broad.mit.edu	37	chr11	4388815	4388815	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccaaatgtgttgagagctttGtggcaagcatctggagaagg	14	6	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:4388815G>C	uc010qye.1	-	1	711	c.711C>G	c.(709-711)CAC>CAG	p.H237Q		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGAGCTTTGTGGCAAGCAT	0.443													0	0	0	0.00308	0	8	81										C	4388815	G	C	4388815	3	2	93	1	0	0	0	0	1	0	0	0	11112	1368	48	4	237	4	OR52B4	11	4388815	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	701412	4388815	130617701	176	27890										
OR51B6	390058	broad.mit.edu	37	chr11	5373369	5373369	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtcttgttggactttctcaTcatctttttctcctacattt	5	10	5	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:5373369T>A	uc010qzb.1	+	1	632	c.632T>A	c.(631-633)ATC>AAC	p.I211N	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GACTTTCTCATCATCTTTTTC	0.443													0	0	0	0.01441	0	44	28										A	5373369	T	A	5373369	3	1	93	1	0	0	0	0	1	0	0	0	11092	1435	50	5	634	5	OR51B6	11	5373369	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	984554	5373369	129633147	177	27891										
DBX1	120237	broad.mit.edu	37	chr11	20181520	20181520	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttacctgttctgggccccgaGgagaggatggcgttcactcc	13	12	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:20181520G>A	uc001mpw.1	-	1	351	c.351C>T	c.(349-351)TCC>TCT	p.S117S		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	117					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGGCCCCGAGGAGAGGATGG	0.642													0	0	0	0.009096	0	4	20										A	20181520	G	A	20181520	2	1	93	1	0	0	0	0	0	0	0	1	4259	987	35	2		2	DBX1	11	20181520	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	14808151	20181520	114824996	178	27892										
GAS2	2620	broad.mit.edu	37	chr11	22759311	22759311	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agagcttggccggattgcagCcaggtaggtcaaaccactgc	13	11	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:22759311C>G	uc009yie.2	+	5	776	c.470C>G	c.(469-471)GCC>GGC	p.A157G	GAS2_uc001mqm.2_Missense_Mutation_p.A157G|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.A157G	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	157					cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						CGGATTGCAGCCAGGTAGGTC	0.468													0	0	0	0.013537	0	12	52										G	22759311	C	G	22759311	3	3	93	1	0	0	0	0	1	0	0	0	6245	739	26	4	484	4	GAS2	11	22759311	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2577791	22759311	112247205	179	27893										
C11orf49	79096	broad.mit.edu	37	chr11	47183188	47183188	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gacagacgagtcggagacttGaggagtccaaagggtcctgc	15	9	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:47183188G>A	uc001ndp.2	+	9	1101	c.995G>A	c.(994-996)TGA>TAA	p.*332*	C11orf49_uc001nds.2_Intron|C11orf49_uc001ndq.2_3'UTR|C11orf49_uc001ndr.2_Silent_p.*338*|C11orf49_uc010rgx.1_Silent_p.*235*|C11orf49_uc010rgy.1_Silent_p.*323*|C11orf49_uc010rgz.1_Silent_p.*248*	NM_024113	NP_077018	Q9H6J7	CK049_HUMAN	hypothetical protein LOC79096 isoform 3	332											0						TCGGAGACTTGAGGAGTCCAA	0.622											OREG0020950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	28	10										A	47183188	G	A	47183188	2	1	93	1	0	0	0	0	0	0	0	1	1645	1285	45	1		1	C11orf49	11	47183188	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	24423877	47183188	87823328	180	27894										
OR5L1	219437	broad.mit.edu	37	chr11	55579623	55579623	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	attctcaccaccatcctgaaGatgggctctgcagagggcag	11	12	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:55579623G>A	uc001nhw.1	+	1	681	c.681G>A	c.(679-681)AAG>AAA	p.K227K		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CCATCCTGAAGATGGGCTCTG	0.498													0	0	0	0.00278	0	24	73										A	55579623	G	A	55579623	2	1	93	1	0	0	0	0	0	0	0	1	11170	933	33	1		1	OR5L1	11	55579623	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	8396435	55579623	79426893	181	27895										
SPRYD5	84767	broad.mit.edu	37	chr11	55658689	55658689	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gaagcatgaatgttggatgtGaccctcaagatgatcccgat	11	8	1	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:55658689G>C	uc010rip.1	+	7	1032	c.940G>C	c.(940-942)GAC>CAC	p.D314H	SPRYD5_uc010riq.1_Missense_Mutation_p.D171H	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	314	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TGTTGGATGTGACCCTCAAGA	0.388													0	0	0	0.01441	0	80	46										C	55658689	G	C	55658689	3	2	93	1	0	0	0	0	1	0	0	0	15110	1290	45	1	962	1	SPRYD5	11	55658689	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	79066	55658689	79347827	182	27896										
PC	5091	broad.mit.edu	37	chr11	66618514	66618514	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acaagtggcccaggcaccttGatgcacaggatgtgggtgcc	14	11	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:66618514G>C	uc001ojn.1	-	15	2269	c.2220C>G	c.(2218-2220)ATC>ATG	p.I740M	PC_uc001ojo.1_Missense_Mutation_p.I740M|PC_uc001ojp.1_Missense_Mutation_p.I740M|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	740	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CAGGCACCTTGATGCACAGGA	0.647													0	0	0	0.003755	0	37	12										C	66618514	G	C	66618514	3	2	93	1	0	0	0	0	1	0	0	0	11497	1280	45	1	1344	1	PC	11	66618514	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	10959825	66618514	68388002	183	27897										
SAPS3	55291	broad.mit.edu	37	chr11	68363617	68363617	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	actctgaagaagaagatggaGcaaagcaagacttgtttgaa	11	5	1	6			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:68363617G>A	uc001onw.2	+	19	2236	c.1969G>A	c.(1969-1971)GCA>ACA	p.A657T	SAPS3_uc001onv.2_Missense_Mutation_p.A657T|SAPS3_uc001ony.3_Missense_Mutation_p.A628T|SAPS3_uc001onx.2_Missense_Mutation_p.A651T|SAPS3_uc009ysh.2_Missense_Mutation_p.A577T|SAPS3_uc001onu.2_Missense_Mutation_p.A577T|SAPS3_uc010rqc.1_Missense_Mutation_p.A425T|SAPS3_uc010rqd.1_Missense_Mutation_p.A340T|SAPS3_uc001onz.2_5'UTR|SAPS3_uc001ooa.2_Missense_Mutation_p.A107T	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	657					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			AGAAGATGGAGCAAAGCAAGA	0.463													0	0	0	0.004672	0	3	75										A	68363617	G	A	68363617	3	1	93	1	0	0	0	0	1	0	0	0	13838	971	34	2	2035	2	SAPS3	11	68363617	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1745103	68363617	66642899	184	27898										
USP35	57558	broad.mit.edu	37	chr11	77921098	77921098	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aggctgagcaggaaaaggaaGaagacagcctgggagcgggg	19	6	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:77921098G>A	uc009yva.1	+	10	2443	c.2197G>A	c.(2197-2199)GAA>AAA	p.E733K	USP35_uc001oze.2_Missense_Mutation_p.E489K|USP35_uc001ozc.2_Missense_Mutation_p.E301K|USP35_uc010rsp.1_Missense_Mutation_p.E165K|USP35_uc001ozd.2_Missense_Mutation_p.E344K|USP35_uc001ozf.2_Missense_Mutation_p.E464K	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	733					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			ggaaaaggaagaagaCAGCCT	0.333													0	0	0	0.013726	0	34	20										A	77921098	G	A	77921098	3	1	93	1	0	0	0	0	1	0	0	0	17063	943	33	1	2231	1	USP35	11	77921098	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	9557481	77921098	57085418	185	27899										
NOX4	50507	broad.mit.edu	37	chr11	89106617	89106617	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tacctgtccagtctcctactAttttaagatgaaccccaaat	4	12	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:89106617A>G	uc001pct.2	-	12	1357	c.1118T>C	c.(1117-1119)ATA>ACA	p.I373T	NOX4_uc009yvr.2_Missense_Mutation_p.I348T|NOX4_uc001pcu.2_Missense_Mutation_p.I299T|NOX4_uc001pcw.2_Missense_Mutation_p.I66T|NOX4_uc001pcx.2_Missense_Mutation_p.I66T|NOX4_uc001pcv.2_Missense_Mutation_p.I373T|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.I207T|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Missense_Mutation_p.I349T|NOX4_uc009yvq.2_Missense_Mutation_p.I349T	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	373	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GTCTCCTACTATTTTAAGATG	0.264													0	0	0	0.01441	0	104	48										G	89106617	A	G	89106617	3	3	93	1	0	0	0	0	1	0	0	0	10558	449	16	5	646	5	NOX4	11	89106617	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	11185519	89106617	45899899	186	27900										
FAT3	120114	broad.mit.edu	37	chr11	92539552	92539552	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	catatacagcattacttcctGaagacattccatcaaataaa	3	10	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:92539552G>A	uc001pdj.3	+	11	9135	c.9118G>A	c.(9118-9120)GAA>AAA	p.E3040K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3040	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTACTTCCTGAAGACATTCC	0.358										TCGA Ovarian(4;0.039)			0	0	0	0.008291	0	11	5										A	92539552	G	A	92539552	3	1	93	1	0	0	0	0	1	0	0	0	5691	1291	45	1	9160	1	FAT3	11	92539552	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3432935	92539552	42466964	187	27901										
VPS11	55823	broad.mit.edu	37	chr11	118948238	118948238	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtgagagtgaagtccactttGatgtggagacagccatcaag	13	7	1	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:118948238G>A	uc010ryx.1	+	10	1495	c.1453G>A	c.(1453-1455)GAT>AAT	p.D485N	VPS11_uc010ryy.1_Missense_Mutation_p.D331N	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	485	Clathrin.				protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		AGTCCACTTTGATGTGGAGAC	0.507													0	0	0	0.005524	0	33	12										A	118948238	G	A	118948238	3	1	93	1	0	0	0	0	1	0	0	0	17185	1290	45	1	1486	1	VPS11	11	118948238	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	26408686	118948238	16058278	188	27902										
OR10S1	219873	broad.mit.edu	37	chr11	123848240	123848240	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aggaggatgaggagattcccAgccacagtgatgctgtagat	14	7	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr11:123848240A>C	uc001pzm.1	-	1	159	c.159T>G	c.(157-159)GCT>GCG	p.A53A		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	53	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGAGATTCCCAGCCACAGTGA	0.532													0	0	0	0.00245	0	14	17										C	123848240	A	C	123848240	2	2	93	1	0	0	0	0	0	0	0	1	10918	175	7	5		5	OR10S1	11	123848240	Silent	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	4900002	123848240	11158276	189	27903										
SLC6A13	6540	broad.mit.edu	37	chr12	344379	344379	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aggtaaggaaatgtggccgtGaagtacaccacctggtcatg	13	8	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:344379G>A	uc001qic.1	-	7	761	c.708C>T	c.(706-708)TTC>TTT	p.F236F	SLC6A13_uc009zdj.1_Silent_p.F236F|SLC6A13_uc010sdl.1_Silent_p.F144F|SLC6A13_uc010sdm.1_Silent_p.F117F	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	236	Helical; Name=5; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			ATGTGGCCGTGAAGTACACCA	0.433													0	0	0	0.001984	0	5	20										A	344379	G	A	344379	2	1	93	1	0	0	0	0	0	0	0	1	14676	1281	45	1		1	SLC6A13	12	344379	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		344379	133507516	190	27904										
LRTM2	654429	broad.mit.edu	37	chr12	1940449	1940449	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagggacctgctgcggcactCgccgctgctccgccacctgg	13	18	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:1940449C>T	uc001qjt.2	+	4	1222	c.416C>T	c.(415-417)TCG>TTG	p.S139L	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Missense_Mutation_p.S139L|LRTM2_uc010sdx.1_Missense_Mutation_p.S139L|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	139	Extracellular (Potential).|LRR 3.					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CTGCGGCACTCGCCGCTGCTC	0.652													0	0	0	0.010504	0	20	58										T	1940449	C	T	1940449	3	4	93	1	0	0	0	0	1	0	0	0	9045	893	31	1	422	1	LRTM2	12	1940449	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1596070	1940449	131911446	191	27905										
PZP	5858	broad.mit.edu	37	chr12	9346775	9346775	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagtaataattggcgtcattCacagagatgaagaagagttt	11	4	2	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:9346775C>G	uc001qvl.2	-	11	1181	c.1152G>C	c.(1150-1152)GTG>GTC	p.V384V	PZP_uc009zgl.2_Silent_p.V253V	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TGGCGTCATTCACAGAGATGA	0.408													0	0	0	0.010504	0	20	38										G	9346775	C	G	9346775	2	3	93	1	0	0	0	0	0	0	0	1	12869	813	29	1		1	PZP	12	9346775	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	7406326	9346775	124505120	192	27906										
SFRS2IP	9169	broad.mit.edu	37	chr12	46342235	46342235	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctaaccttatacagcttttaGaattttcatgacaggagacc	6	9	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:46342235G>C	uc001rox.2	-	5	670	c.383C>G	c.(382-384)TCT>TGT	p.S128C	SFRS2IP_uc001roy.1_Missense_Mutation_p.S202C	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	128					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		ACAGCTTTTAGAATTTTCATG	0.313													0	0	0	0.001855	0	14	46										C	46342235	G	C	46342235	3	2	93	1	0	0	0	0	1	0	0	0	14177	942	33	1	4052	1	SFRS2IP	12	46342235	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	36995460	46342235	87509660	193	27907										
MLL2	8085	broad.mit.edu	37	chr12	49445896	49445896	+	Frame_Shift_Del	DEL	C	C	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aggagatgggggtgactcttCcggtggagacaagggcgact							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:49445896delC	uc001rta.3	-	10	1570	c.1570delG	c.(1570-1572)GAAfs	p.E524fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	524	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.|6.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGTGACTCTTCCGGTGGAGAC	0.597			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								17	55	---	---								-	49445896	C	-	49445896	7	5	93	1	0	1	0	1	0	0	0	0	9621	864	30	0	15223	0	MLL2	12	49445896	Frame_Shift_Del	DEL	C	TCGA-G2-A2EF-01A-12D-A18F-08	3103661	49445896	84405999	194	27908										
SUOX	6821	broad.mit.edu	37	chr12	56397462	56397462	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgagttcccacaccagccctGagactgggatctgggtgact	12	12	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:56397462G>C	uc001six.2	+	6	615	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	SUOX_uc001siy.2_Missense_Mutation_p.E97Q|SUOX_uc001siz.2_Missense_Mutation_p.E97Q|SUOX_uc001sja.2_Missense_Mutation_p.E97Q	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	97	Cytochrome b5 heme-binding.					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			CACCAGCCCTGAGACTGGGAT	0.512													0	0	0	0.007413	0	19	86										C	56397462	G	C	56397462	3	2	93	1	0	0	0	0	1	0	0	0	15392	1291	45	1	299	1	SUOX	12	56397462	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	6951566	56397462	77454433	195	27909										
ERBB3	2065	broad.mit.edu	37	chr12	56486584	56486584	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agagaagctcaatgtcttccGgacagtacgggagatcacag	12	9	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:56486584G>A	uc001sjh.2	+	10	1356	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.R329Q|ERBB3_uc009zok.2_5'Flank|ERBB3_uc001sjj.1_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	388	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AATGTCTTCCGGACAGTACGG	0.448													0	0	0	0.00245	0	12	123										A	56486584	G	A	56486584	3	1	93	1	0	0	0	0	1	0	0	0	5208	1116	39	2	1332	2	ERBB3	12	56486584	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	89122	56486584	77365311	196	27910										
LRP1	4035	broad.mit.edu	37	chr12	57579595	57579595	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	actaccgggcaggcacctctCcgggcacccccaatcgcatc	9	19	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:57579595C>T	uc001snd.2	+	41	7211	c.6745C>T	c.(6745-6747)CCG>TCG	p.P2249S		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2249	Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGGCACCTCTCCGGGCACCCC	0.577													0	0	0	0.01441	0	47	44										T	57579595	C	T	57579595	3	4	93	1	0	0	0	0	1	0	0	0	8951	855	30	1	6907	1	LRP1	12	57579595	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1093011	57579595	76272300	197	27911										
USP15	9958	broad.mit.edu	37	chr12	62790135	62790135	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggtccttgccgctataatctGattgctgtttccaaccacta	7	12	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:62790135G>C	uc001src.1	+	20	2640	c.2631G>C	c.(2629-2631)CTG>CTC	p.L877L	USP15_uc001srb.1_Silent_p.L848L	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	877					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GCTATAATCTGATTGCTGTTT	0.393													0	0	0	0.013537	0	12	54										C	62790135	G	C	62790135	2	2	93	1	0	0	0	0	0	0	0	1	17043	1277	45	1		1	USP15	12	62790135	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5210540	62790135	71061760	198	27912										
CAPS2	84698	broad.mit.edu	37	chr12	75676043	75676043	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ataattacctgaaattacttGagaatgcttctttgcacagt	6	7	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:75676043G>A	uc001sxk.3	-	17	1854	c.1657C>T	c.(1657-1659)CAA>TAA	p.Q553*	CAPS2_uc001sxm.3_Nonsense_Mutation_p.Q321*|CAPS2_uc009zsa.2_Nonsense_Mutation_p.Q143*|CAPS2_uc001sxi.3_Nonsense_Mutation_p.Q289*|CAPS2_uc001sxj.3_Nonsense_Mutation_p.Q464*|CAPS2_uc001sxl.3_Nonsense_Mutation_p.Q534*	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	553							calcium ion binding			ovary(2)	2						GAAATTACTTGAGAATGCTTC	0.284													0	0	0	0.010504	0	21	106										A	75676043	G	A	75676043	4	1	93	1	0	0	0	0	0	1	0	0	2638	1299	45	1	24	1	CAPS2	12	75676043	Nonsense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	12885908	75676043	58175852	199	27913										
MYF5	4617	broad.mit.edu	37	chr12	81111211	81111211	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aggctgcccaaggtggagatCctcaggaatgccatccgcta	12	12	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:81111211C>T	uc001szg.2	+	1	504	c.369C>T	c.(367-369)ATC>ATT	p.I123I		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	123	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						AGGTGGAGATCCTCAGGAATG	0.597													0	0	0	0.00278	0	22	134										T	81111211	C	T	81111211	2	4	93	1	0	0	0	0	0	0	0	1	10027	845	30	1		1	MYF5	12	81111211	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	5435168	81111211	52740684	200	27914										
CCDC38	120935	broad.mit.edu	37	chr12	96312708	96312708	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agaaagagatctctgaaaaaGatcttataaggcctgtcctc	8	8	2	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:96312708G>C	uc001tek.1	-	3	318	c.84C>G	c.(82-84)ATC>ATG	p.I28M		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	28										skin(1)	1						CTCTGAAAAAGATCTTATAAG	0.338													0	0	0	0.001855	0	12	86										C	96312708	G	C	96312708	3	2	93	1	0	0	0	0	1	0	0	0	2810	932	33	1	1663	1	CCDC38	12	96312708	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	15201497	96312708	37539187	201	27915										
GAS2L3	283431	broad.mit.edu	37	chr12	101017394	101017394	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtggaggctgggatactcttCaaggatttttgcttaaatat	11	5	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:101017394C>T	uc001thu.2	+	10	1037	c.811C>T	c.(811-813)CAA>TAA	p.Q271*	GAS2L3_uc009zty.2_Nonsense_Mutation_p.Q271*|GAS2L3_uc001thv.2_Nonsense_Mutation_p.Q167*	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	271	GAR.				cell cycle arrest					skin(1)	1						GGATACTCTTCAAGGATTTTT	0.378													0	0	0	0.01441	0	74	59										T	101017394	C	T	101017394	4	4	93	1	0	0	0	0	0	1	0	0	6248	827	29	1	841	1	GAS2L3	12	101017394	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	4704686	101017394	32834501	202	27916										
APPL2	55198	broad.mit.edu	37	chr12	105570747	105570747	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atgacaaaaccaaccagtctCttgttttcttgatgagcagc	7	10	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:105570747C>G	uc001tlf.1	-	19	1937	c.1719G>C	c.(1717-1719)AAG>AAC	p.K573N	APPL2_uc010swt.1_Missense_Mutation_p.K530N|APPL2_uc001tlg.1_Missense_Mutation_p.K327N|APPL2_uc010swu.1_Missense_Mutation_p.K579N	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	573	PID.				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CAACCAGTCTCTTGTTTTCTT	0.398													0	0	0	0.007291	0	30	34										G	105570747	C	G	105570747	3	3	93	1	0	0	0	0	1	0	0	0	818	912	32	1	287	1	APPL2	12	105570747	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	4553353	105570747	28281148	203	27917										
MVK	4598	broad.mit.edu	37	chr12	110024578	110024578	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggaggagccctccgataccaTcaagggaagatttcatcctt	10	11	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:110024578T>C	uc001toy.3	+	7	835	c.651T>C	c.(649-651)CAT>CAC	p.H217H	MVK_uc009zvk.2_Silent_p.H217H|MVK_uc010sxr.1_Silent_p.H165H|MVK_uc001toz.3_Silent_p.H23H|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	217					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						TCCGATACCATCAAGGGAAGA	0.507													0	0	0	0.00308	0	7	124										C	110024578	T	C	110024578	2	2	93	1	0	0	0	0	0	0	0	1	9995	1432	50	5		5	MVK	12	110024578	Silent	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	4453831	110024578	23827317	204	27918										
C12orf43	64897	broad.mit.edu	37	chr12	121454205	121454205	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cattgccgcctcgcggcaccGctccagctcctccgcatcgc	9	21	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:121454205G>C	uc001tzh.1	-	1	96	c.73C>G	c.(73-75)CGG>GGG	p.R25G	C12orf43_uc009zxa.1_Missense_Mutation_p.R25G|C12orf43_uc010szo.1_5'UTR|C12orf43_uc010szp.1_Missense_Mutation_p.R25G|C12orf43_uc001tzi.1_Missense_Mutation_p.R25G	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	25											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCGCGGCACCGCTCCAGCTCC	0.622													0	0	0	0.001168	0	5	74										C	121454205	G	C	121454205	3	2	93	1	0	0	0	0	1	0	0	0	1689	1086	38	4	739	4	C12orf43	12	121454205	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	11429627	121454205	12397690	205	27919										
RNF34	80196	broad.mit.edu	37	chr12	121867872	121867872	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gccgccttagaaatggtccaGaaagcagtgcagttacgatt	11	9	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:121867872G>C	uc001uam.1	+	7	1213	c.1099G>C	c.(1099-1101)GAA>CAA	p.E367Q	KDM2B_uc001uaq.2_3'UTR|KDM2B_uc010szy.1_3'UTR|KDM2B_uc001uar.2_3'UTR|KDM2B_uc001uas.2_3'UTR|KDM2B_uc001uat.2_3'UTR|KDM2B_uc001uau.2_3'UTR|KDM2B_uc001uao.2_3'UTR|KDM2B_uc010szx.1_3'UTR|KDM2B_uc001uap.2_RNA	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		AAATGGTCCAGAAAGCAGTGC	0.483													0	0	0	0.001855	0	12	59										C	121867872	G	C	121867872	3	2	93	1	0	0	0	0	1	0	0	0	13489	957	33	1		1	RNF34	12	121867872	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	413667	121867872	11984023	206	27920										
ULK1	8408	broad.mit.edu	37	chr12	132403850	132403850	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccctgaagggcagcgccagtGaggcggcggggggccctgag	20	12	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:132403850G>A	uc001uje.2	+	24	2873	c.2605G>A	c.(2605-2607)GAG>AAG	p.E869K		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	869					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CAGCGCCAGTGAGGCGGCGGG	0.682													0	0	0	0.003163	0	14	33										A	132403850	G	A	132403850	3	1	93	1	0	0	0	0	1	0	0	0	16972	1291	45	1	2699	1	ULK1	12	132403850	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	10535978	132403850	1448045	207	27921										
PUS1	80324	broad.mit.edu	37	chr12	132426135	132426135	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagggcctggagtttgcggtGatcagggtgaagggccagag	20	6	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:132426135G>C	uc001ujf.2	+	5	1322	c.843G>C	c.(841-843)GTG>GTC	p.V281V	PUS1_uc001ujg.2_Silent_p.V253V|PUS1_uc001ujh.2_Silent_p.V253V|PUS1_uc001uji.2_Silent_p.V228V	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	281						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		AGTTTGCGGTGATCAGGGTGA	0.607													0	0	0	0.01441	0	60	56										C	132426135	G	C	132426135	2	2	93	1	0	0	0	0	0	0	0	1	12830	1277	45	1		1	PUS1	12	132426135	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	22285	132426135	1425760	208	27922										
PUS1	80324	broad.mit.edu	37	chr12	132426465	132426465	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cgctccatggcccagtggctGagcaccttgcccatccacaa	9	17	0	1	rs142637371		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr12:132426465G>C	uc001ujf.2	+	5	1652	c.1173G>C	c.(1171-1173)CTG>CTC	p.L391L	PUS1_uc001ujg.2_Silent_p.L363L|PUS1_uc001ujh.2_Silent_p.L363L|PUS1_uc001uji.2_Silent_p.L338L	NM_025215	NP_079491	Q9Y606	TRUA_HUMAN	pseudouridine synthase 1 isoform 1	391						mitochondrion	pseudouridine synthase activity|pseudouridylate synthase activity|RNA binding			breast(1)|central_nervous_system(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.05e-08)|Epithelial(86;2.51e-07)|all cancers(50;2.94e-07)		CCCAGTGGCTGAGCACCTTGC	0.637													0	0	0	0.012213	0	33	24										C	132426465	G	C	132426465	2	2	93	1	0	0	0	0	0	0	0	1	12830	1277	45	1		1	PUS1	12	132426465	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	330	132426465	1425430	209	27923										
SKA3	221150	broad.mit.edu	37	chr13	21736001	21736001	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	attgagcctggattctgtatCtatggcctcctcactggtgt	10	10	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:21736001C>T	uc001unt.2	-	5	851	c.757G>A	c.(757-759)GAT>AAT	p.D253N	SKA3_uc001unv.2_Missense_Mutation_p.D171N|SKA3_uc001unu.2_Missense_Mutation_p.D253N	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	253					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						GATTCTGTATCTATGGCCTCC	0.363													0	0	0	0.001984	0	6	15										T	21736001	C	T	21736001	3	4	93	1	0	0	0	0	1	0	0	0	14354	913	32	1	548	1	SKA3	13	21736001	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		21736001	93433877	210	27924										
FAM48A	55578	broad.mit.edu	37	chr13	37584737	37584737	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcagaggagagctggaatctCtgctgaggaaggctttgctc	15	8	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:37584737C>T	uc001uwg.2	-	25	2402	c.2154G>A	c.(2152-2154)CAG>CAA	p.Q718Q	FAM48A_uc010abt.2_Intron|FAM48A_uc001uwh.2_Intron|FAM48A_uc001uwi.2_Intron|FAM48A_uc001uwj.2_Intron|FAM48A_uc001uwk.2_Intron|FAM48A_uc001uwd.2_Intron|FAM48A_uc001uwe.2_Silent_p.Q202Q|FAM48A_uc001uwf.2_Silent_p.Q284Q	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	718	Gln-rich.				autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		GCTGGAATCTCTGCTGAGGAA	0.463													0	0	0	0.00278	0	21	56										T	37584737	C	T	37584737	2	4	93	1	0	0	0	0	0	0	0	1	5572	912	32	1		1	FAM48A	13	37584737	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	15848736	37584737	77585141	211	27925										
DIS3	22894	broad.mit.edu	37	chr13	73334716	73334716	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tctgatgttgaagattagatGagtctaacatgattttcact	8	5	3	6			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:73334716G>A	uc001vix.3	-	20	3118	c.2744C>T	c.(2743-2745)TCA>TTA	p.S915L	DIS3_uc001viy.3_Missense_Mutation_p.S885L|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	915					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AAGATTAGATGAGTCTAACAT	0.328										Multiple Myeloma(4;0.011)			0	0	0	0.01441	0	53	36										A	73334716	G	A	73334716	3	1	93	1	0	0	0	0	1	0	0	0	4535	1294	45	1	140	1	DIS3	13	73334716	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	35749979	73334716	41835162	212	27926										
TPP2	7174	broad.mit.edu	37	chr13	103301811	103301811	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgcaggatccttaacattgtCaaagactgaactaggaaaga	9	7	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:103301811C>G	uc001vpi.3	+	23	3030	c.2927C>G	c.(2926-2928)TCA>TGA	p.S976*		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	976					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTAACATTGTCAAAGACTGAA	0.303													0	0	0	0.004007	0	12	72										G	103301811	C	G	103301811	4	3	93	1	0	0	0	0	0	1	0	0	16409	838	29	1	3017	1	TPP2	13	103301811	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	29967095	103301811	11868067	213	27927										
ARHGEF7	8874	broad.mit.edu	37	chr13	111932947	111932947	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aggatctgcaggaatgggtgGagcacctacagaagcaaacg	14	8	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr13:111932947G>C	uc001vrs.2	+	16	1961	c.1711G>C	c.(1711-1713)GAG>CAG	p.E571Q	ARHGEF7_uc001vrr.2_Missense_Mutation_p.E550Q|ARHGEF7_uc001vrt.2_Missense_Mutation_p.E521Q|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Missense_Mutation_p.E393Q|ARHGEF7_uc001vrv.3_Missense_Mutation_p.E393Q|ARHGEF7_uc001vrw.3_Missense_Mutation_p.E393Q|ARHGEF7_uc001vrx.3_Missense_Mutation_p.E393Q|ARHGEF7_uc010tjo.1_Missense_Mutation_p.E468Q|ARHGEF7_uc010tjp.1_Missense_Mutation_p.E315Q|ARHGEF7_uc001vry.1_5'Flank	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	571	PH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			GGAATGGGTGGAGCACCTACA	0.498													0	0	0	0.01441	0	75	78										C	111932947	G	C	111932947	3	2	93	1	0	0	0	0	1	0	0	0	911	1175	41	1	1773	1	ARHGEF7	13	111932947	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	8631136	111932947	3236931	214	27928										
OR10G2	26534	broad.mit.edu	37	chr14	22102290	22102290	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gaaggcccggcgcctcccatCagcggtgcgtatcttcagga	13	14	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:22102290C>A	uc010tmc.1	-	1	709	c.709G>T	c.(709-711)GAT>TAT	p.D237Y		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CGCCTCCCATCAGCGGTGCGT	0.542													1	0	7.45023e-12	0.010504	7.9146e-12	21	24										A	22102290	C	A	22102290	3	1	93	1	0	0	0	0	1	0	0	0	10899	826	29	3	226	3	OR10G2	14	22102290	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		22102290	85247250	215	27929										
OR10G2	26534	broad.mit.edu	37	chr14	22102306	22102306	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccatcagcggtgcgtatcttCaggatggcatggactatgtt	12	9	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:22102306C>T	uc010tmc.1	-	1	693	c.693G>A	c.(691-693)CTG>CTA	p.L231L		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TGCGTATCTTCAGGATGGCAT	0.532													0	0	0	0.006122	0	18	24										T	22102306	C	T	22102306	2	4	93	1	0	0	0	0	0	0	0	1	10899	813	29	1		1	OR10G2	14	22102306	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	16	22102306	85247234	216	27930										
PSMB5	5693	broad.mit.edu	37	chr14	23502856	23502856	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acccgctgtagccctggagtCagctgcaactatgactccat	9	14	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:23502856C>G	uc001wii.2	-	2	490	c.226G>C	c.(226-228)GAC>CAC	p.D76H	PSMB5_uc001wij.2_Missense_Mutation_p.D76H|PSMB5_uc010tni.1_5'UTR	NM_002797	NP_002788	P28074	PSB5_HUMAN	proteasome beta 5 subunit isoform 1	76					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	GCCCTGGAGTCAGCTGCAACT	0.507													0	0	0	0.003163	0	14	27										G	23502856	C	G	23502856	3	3	93	1	0	0	0	0	1	0	0	0	12680	826	29	1	662	1	PSMB5	14	23502856	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1400550	23502856	83846684	217	27931										
INSM2	84684	broad.mit.edu	37	chr14	36005008	36005008	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtcgggccctagcgggccatCtgacgggagtgcccagcaaa	15	13	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:36005008C>G	uc001wth.1	+	1	1761	c.1550C>G	c.(1549-1551)TCT>TGT	p.S517C		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		AGCGGGCCATCTGACGGGAGT	0.627													0	0	0	0.010729	0	12	22										G	36005008	C	G	36005008	3	3	93	1	0	0	0	0	1	0	0	0	7772	913	32	1	1552	1	INSM2	14	36005008	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	12502152	36005008	71344532	218	27932										
HIF1A	3091	broad.mit.edu	37	chr14	62207727	62207727	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atggaagacattaaaatattGattgcatctccatctcctac	5	9	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:62207727G>A	uc001xfq.2	+	12	2318	c.1914G>A	c.(1912-1914)TTG>TTA	p.L638L	HIF1A_uc001xfr.2_Silent_p.L638L|HIF1A_uc001xfs.2_Silent_p.L639L	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	638	ID.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		TTAAAATATTGATTGCATCTC	0.408													0	0	0	0.005443	0	27	28										A	62207727	G	A	62207727	2	1	93	1	0	0	0	0	0	0	0	1	7103	1281	45	1		1	HIF1A	14	62207727	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	26202719	62207727	45141813	219	27933										
CYP46A1	10858	broad.mit.edu	37	chr14	100157465	100157465	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttggaaaaaggatgaggttgGtggccgtgtgctccaagatg	16	5	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr14:100157465G>A	uc001ygo.2	+	2	167	c.167G>A	c.(166-168)GGT>GAT	p.G56D	CYP46A1_uc001ygn.1_Missense_Mutation_p.V4M	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	56					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GATGAGGTTGGTGGCCGTGTG	0.493													0	0	0	0.010771	0	38	66										A	100157465	G	A	100157465	3	1	93	1	0	0	0	0	1	0	0	0	4182	1261	44	2	173	2	CYP46A1	14	100157465	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	37949738	100157465	7192075	220	27934										
GCHFR	2644	broad.mit.edu	37	chr15	41056393	41056393	+	Silent	SNP	C	C	T													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgcaccatgccctacctgctCatcagcacccagatccgcat							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:41056393C>T	uc001zmr.1	+	1	109	c.15C>T	c.(13-15)CTC>CTT	p.L5L	GCHFR_uc010ucr.1_Silent_p.L5L	NM_005258	NP_005249	P30047	GFRP_HUMAN	GTP cyclohydrolase I feedback regulatory	5					negative regulation of biosynthetic process|neurotransmitter metabolic process|nitric oxide biosynthetic process	cytosol|dendrite|melanosome|nuclear membrane				ovary(1)	1		all_cancers(109;3.3e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CCTACCTGCTCATCAGCACCC	0.701													0	0	0	0.009096	0	4	1										T	41056393	C	T	41056393	2	4	93	1	0	0	0	0	0	0	0	1	6292	813	29	1		1	GCHFR	15	41056393	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		41056393	61474999	221	27935	139	2								
GCHFR	2644	broad.mit.edu	37	chr15	41056396	41056396	+	Silent	SNP	C	C	T													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	accatgccctacctgctcatCagcacccagatccgcatggt							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:41056396C>T	uc001zmr.1	+	1	112	c.18C>T	c.(16-18)ATC>ATT	p.I6I	GCHFR_uc010ucr.1_Silent_p.I6I	NM_005258	NP_005249	P30047	GFRP_HUMAN	GTP cyclohydrolase I feedback regulatory	6					negative regulation of biosynthetic process|neurotransmitter metabolic process|nitric oxide biosynthetic process	cytosol|dendrite|melanosome|nuclear membrane				ovary(1)	1		all_cancers(109;3.3e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		ACCTGCTCATCAGCACCCAGA	0.701													0	0	0	0.000602	0	5	1										T	41056396	C	T	41056396	2	4	93	1	0	0	0	0	0	0	0	1	6292	816	29	1		1	GCHFR	15	41056396	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3	41056396	61474996	222	27936	139	2								
UNC13C	440279	broad.mit.edu	37	chr15	54630580	54630580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttctggagctgcaaagccccCcaaaagcgagcatggtggtg	13	11	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:54630580C>T	uc002ack.2	+	15	4606	c.4606C>T	c.(4606-4608)CCA>TCA	p.P1536S	UNC13C_uc002acl.2_Missense_Mutation_p.P366S	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1536					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GCAAAGCCCCCCAAAAGCGAG	0.403													0	0	0	0.01441	0	53	35										T	54630580	C	T	54630580	3	4	93	1	0	0	0	0	1	0	0	0	16983	623	22	2	4664	2	UNC13C	15	54630580	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	13574184	54630580	47900812	223	27937										
RNF111	54778	broad.mit.edu	37	chr15	59350651	59350651	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atctacctctgagcaggcctCtgatactgcttcagctgtca	8	13	5	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:59350651C>T	uc002afv.2	+	5	1547	c.1268C>T	c.(1267-1269)TCT>TTT	p.S423F	RNF111_uc002afs.2_Missense_Mutation_p.S423F|RNF111_uc002aft.2_Missense_Mutation_p.S423F|RNF111_uc002afu.2_Missense_Mutation_p.S423F|RNF111_uc002afw.2_Missense_Mutation_p.S423F	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	423	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		GAGCAGGCCTCTGATACTGCT	0.458													0	0	0	0.01441	0	154	113										T	59350651	C	T	59350651	3	4	93	1	0	0	0	0	1	0	0	0	13425	913	32	1	1282	1	RNF111	15	59350651	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	4720071	59350651	43180741	224	27938			1	124		3	3	91	C		4.039764e-07
RNF111	54778	broad.mit.edu	37	chr15	59350705	59350705	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttccacagtgtcagagacttCagctactcttacaagcaata	6	11	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:59350705C>T	uc002afv.2	+	5	1601	c.1322C>T	c.(1321-1323)TCA>TTA	p.S441L	RNF111_uc002afs.2_Missense_Mutation_p.S441L|RNF111_uc002aft.2_Missense_Mutation_p.S441L|RNF111_uc002afu.2_Missense_Mutation_p.S441L|RNF111_uc002afw.2_Missense_Mutation_p.S441L	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	441	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		TCAGAGACTTCAGCTACTCTT	0.448													0	0	0	0.01441	0	129	112										T	59350705	C	T	59350705	3	4	93	1	0	0	0	0	1	0	0	0	13425	838	29	1	1336	1	RNF111	15	59350705	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	54	59350705	43180687	225	27939			1	124		3	3	91	C		4.039764e-07
RNF111	54778	broad.mit.edu	37	chr15	59350741	59350741	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	caatagtaccactggcacttCtataggaggtatgtaaaaaa	8	7	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:59350741C>G	uc002afv.2	+	5	1637	c.1358C>G	c.(1357-1359)TCT>TGT	p.S453C	RNF111_uc002afs.2_Missense_Mutation_p.S453C|RNF111_uc002aft.2_Missense_Mutation_p.S453C|RNF111_uc002afu.2_Missense_Mutation_p.S453C|RNF111_uc002afw.2_Missense_Mutation_p.S453C	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	453	Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		ACTGGCACTTCTATAGGAGGT	0.413													0	0	0	0.01441	0	118	78										G	59350741	C	G	59350741	3	3	93	1	0	0	0	0	1	0	0	0	13425	913	32	1	1372	1	RNF111	15	59350741	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	36	59350741	43180651	226	27940			1	124		3	3	91	C		4.039764e-07
AGBL1	123624	broad.mit.edu	37	chr15	86790936	86790936	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agagcagtgaaccgaggctaCgtcaccagcctgctcgggct	13	13	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr15:86790936C>T	uc002blz.1	+	6	503	c.423C>T	c.(421-423)TAC>TAT	p.Y141Y		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	141					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						ACCGAGGCTACGTCACCAGCC	0.592													0	0	0	0.006214	0	10	8										T	86790936	C	T	86790936	2	4	93	1	0	0	0	0	0	0	0	1	375	547	19	2		2	AGBL1	15	86790936	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	27440195	86790936	15740456	227	27941										
UBN1	29855	broad.mit.edu	37	chr16	4908646	4908646	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tatgatgaatccgactccttCatcgataactctgaggcggt	9	10	2	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:4908646C>T	uc002cyb.2	+	4	753	c.414C>T	c.(412-414)TTC>TTT	p.F138F	UBN1_uc010uxw.1_Silent_p.F138F|UBN1_uc002cyc.2_Silent_p.F138F	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	138	Sufficient for interaction with HIRA.			F->E: Strongly diminishes interaction with HIRA; when associated with E-139 and L-140.	chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CCGACTCCTTCATCGATAACT	0.463													0	0	0	0.006214	0	10	16										T	4908646	C	T	4908646	2	4	93	1	0	0	0	0	0	0	0	1	16889	825	29	1		1	UBN1	16	4908646	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		4908646	85446107	228	27942										
INO80E	283899	broad.mit.edu	37	chr16	30007659	30007659	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggccggcggacggcgaagtgGactacaaaaaaaaataccgg	14	9	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:30007659G>C	uc002dvg.1	+	1	129	c.28G>C	c.(28-30)GAC>CAC	p.D10H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvh.1_RNA|INO80E_uc002dvi.1_Missense_Mutation_p.D10H|INO80E_uc002dvj.1_RNA|INO80E_uc002dvk.1_Missense_Mutation_p.D10H|HIRIP3_uc002dve.2_5'Flank|HIRIP3_uc002dvf.2_5'Flank	NM_173618	NP_775889	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	10	Potential.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				skin(1)	1						CGGCGAAGTGGACTACAAAAA	0.652													0	0	0	0.001168	0	5	10										C	30007659	G	C	30007659	3	2	93	1	0	0	0	0	1	0	0	0	7750	1174	41	1	30	1	INO80E	16	30007659	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	25099013	30007659	60347094	229	27943										
RBL2	5934	broad.mit.edu	37	chr16	53488655	53488655	+	Frame_Shift_Del	DEL	G	G	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cttggagaggatgctgaggaGgaaattgggactctctcaag							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:53488655delG	uc002ehi.3	+	8	1198	c.1080delG	c.(1078-1080)GAGfs	p.E360fs	RBL2_uc010vgv.1_Frame_Shift_Del_p.E286fs|RBL2_uc002ehj.2_Frame_Shift_Del_p.E70fs|RBL2_uc010vgw.1_Frame_Shift_Del_p.E144fs	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	360					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ATGCTGAGGAGGAAATTGGGA	0.428																		29	31	---	---								-	53488655	G	-	53488655	7	5	93	1	0	1	0	1	0	0	0	0	13110	991	35	0	1110	0	RBL2	16	53488655	Frame_Shift_Del	DEL	G	TCGA-G2-A2EF-01A-12D-A18F-08	23480996	53488655	36866098	230	27944										
TPPP3	51673	broad.mit.edu	37	chr16	67424463	67424463	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcctccttgctcttccccttGaatctcttggtcgccagctc	6	17	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:67424463G>C	uc002esz.2	-	2	1096	c.261C>G	c.(259-261)TTC>TTG	p.F87L	TPPP3_uc002eta.2_Missense_Mutation_p.F87L|TPPP3_uc002etb.2_Missense_Mutation_p.F87L	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family	87					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		TCTTCCCCTTGAATCTCTTGG	0.582													0	0	0	0.01441	0	158	88										C	67424463	G	C	67424463	3	2	93	1	0	0	0	0	1	0	0	0	16412	1281	45	1	277	1	TPPP3	16	67424463	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	13935808	67424463	22930290	231	27945										
SLC12A4	6560	broad.mit.edu	37	chr16	67986272	67986272	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	atattgttcaaagtggcattCgacgtgtcatgagcacccga	10	9	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:67986272C>A	uc002euz.2	-	7	873	c.732G>T	c.(730-732)TCG>TCT	p.S244S	SLC12A4_uc010ceu.2_Silent_p.S238S|SLC12A4_uc010vkh.1_Silent_p.S213S|SLC12A4_uc010vki.1_Silent_p.S244S|SLC12A4_uc010vkj.1_Silent_p.S246S|SLC12A4_uc002eva.2_Silent_p.S244S|SLC12A4_uc002evb.2_RNA|SLC12A4_uc010cew.1_Missense_Mutation_p.R166L	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	244					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAGTGGCATTCGACGTGTCAT	0.453													1	0	1.32136e-16	0.00874	1.41522e-16	44	16										A	67986272	C	A	67986272	2	1	93	1	0	0	0	0	0	0	0	1	14385	871	31	3		3	SLC12A4	16	67986272	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	561809	67986272	22368481	232	27946										
COG8	84342	broad.mit.edu	37	chr16	69373430	69373430	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctgctgtggccgtggctaccGatgggatagtcgccgcggtc	16	12	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:69373430G>A	uc002ewy.2	-	1	97	c.26C>T	c.(25-27)TCG>TTG	p.S9L	COG8_uc002ewz.3_Missense_Mutation_p.S9L|NIP7_uc002exa.2_5'Flank|NIP7_uc002exb.2_5'Flank	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	9					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						CGTGGCTACCGATGGGATAGT	0.652											OREG0023907	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	19	4										A	69373430	G	A	69373430	3	1	93	1	0	0	0	0	1	0	0	0	3664	1059	37	1	1832	1	COG8	16	69373430	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1387158	69373430	20981323	233	27947										
ZC3H18	124245	broad.mit.edu	37	chr16	88677707	88677707	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggagcgagagagagagaacaGacagcgcgagcgcgagcggg	20	8	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:88677707G>A	uc002fky.2	+	8	1438	c.1238G>A	c.(1237-1239)AGA>AAA	p.R413K	ZC3H18_uc010voy.1_Missense_Mutation_p.R296K|ZC3H18_uc010voz.1_Missense_Mutation_p.R437K|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	413	Potential.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		agagagaacagacagcgcgag	0													0	0	0	0.010504	0	22	6										A	88677707	G	A	88677707	3	1	93	1	0	0	0	0	1	0	0	0	17565	942	33	1	1264	1	ZC3H18	16	88677707	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	19304277	88677707	1677046	234	27948										
TUBB3	10381	broad.mit.edu	37	chr16	90001896	90001896	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctacttcgtggagtggatccCcaacaacgtgaaggtggccg	13	11	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr16:90001896C>T	uc002fph.1	+	4	1102	c.1037C>T	c.(1036-1038)CCC>CTC	p.P346L	TUBB3_uc002fpf.2_Missense_Mutation_p.P693L|TUBB3_uc010ciz.1_Missense_Mutation_p.P274L|TUBB3_uc002fpg.1_Missense_Mutation_p.P200L|TUBB3_uc002fpi.1_Missense_Mutation_p.P274L|TUBB3_uc002fpj.1_Missense_Mutation_p.P274L|TUBB3_uc010cjb.1_Missense_Mutation_p.P200L|TUBB3_uc002fpk.1_Missense_Mutation_p.P200L	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	346					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GAGTGGATCCCCAACAACGTG	0.612													0	0	0	0.01441	0	139	60										T	90001896	C	T	90001896	3	4	93	1	0	0	0	0	1	0	0	0	16754	623	22	2	1051	2	TUBB3	16	90001896	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1324189	90001896	352857	235	27949										
SMYD4	114826	broad.mit.edu	37	chr17	1703353	1703353	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctgcacagtgcagaaacacaGagagcacagaggaatttgtg	12	8	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:1703353G>C	uc002ftm.3	-	5	1503	c.1335C>G	c.(1333-1335)CTC>CTG	p.L445L	SMYD4_uc002ftn.1_Silent_p.L300L	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	445							zinc ion binding			skin(3)|kidney(2)	5						CAGAAACACAGAGAGCACAGA	0.453													0	0	0	0.004289	0	38	33										C	1703353	G	C	1703353	2	2	93	1	0	0	0	0	0	0	0	1	14824	929	33	1		1	SMYD4	17	1703353	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		1703353	79491857	236	27950										
SMYD4	114826	broad.mit.edu	37	chr17	1704320	1704321	+	Splice_Site	INS	-	-	C													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aatgtctttaagacacgtctINSgaaaacagaaagaaaatccc							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:1704320_1704321insC	uc002ftm.3	-	5	538	c.370_splice	c.e5-1	p.T124_splice	SMYD4_uc002ftn.1_Splice_Site	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4								zinc ion binding			skin(3)|kidney(2)	5						AAGACACGTCTGAAAACAGAAA	0.381																		36	67	---	---								C	1704321	-	C	1704320	8	5	93	1	0	1	1	0	0	0	1	0	14824	1594	55	0	2074	0	SMYD4	17	1704320	Splice_Site	INS	-	TCGA-G2-A2EF-01A-12D-A18F-08	967	1704320	79490890	237	27951										
ATP1B2	482	broad.mit.edu	37	chr17	7554879	7554879	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agagctgcgggcaggtggttGaggagtggaaggagttcgtg	21	4	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:7554879G>C	uc002gif.1	+	1	626	c.43G>C	c.(43-45)GAG>CAG	p.E15Q		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	15	Cytoplasmic (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GCAGGTGGTTGAGGAGTGGAA	0.697													0	0	0	0.004672	0	2	6										C	7554879	G	C	7554879	3	2	93	1	0	0	0	0	1	0	0	0	1133	1291	45	1	45	1	ATP1B2	17	7554879	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5850559	7554879	73640331	238	27952										
ALOXE3	59344	broad.mit.edu	37	chr17	8018956	8018956	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttgtcgggcccggagctcccGtgtcctgtgatccaggagga	15	12	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:8018956G>A	uc010cnr.2	-	4	773	c.403C>T	c.(403-405)CGG>TGG	p.R135W	ALOXE3_uc002gka.2_Missense_Mutation_p.R291W|ALOXE3_uc010vuo.1_Missense_Mutation_p.R267W|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	135	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CGGAGCTCCCGTGTCCTGTGA	0.473													0	0	0	0.007835	0	36	26										A	8018956	G	A	8018956	3	1	93	1	0	0	0	0	1	0	0	0	542	1144	40	2	1784	2	ALOXE3	17	8018956	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	464077	8018956	73176254	239	27953										
NTN1	9423	broad.mit.edu	37	chr17	8926345	8926345	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cgctctcgggcggcctcatcGccttcagcacgctggacggg	14	16	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:8926345G>A	uc002glw.3	+	2	762	c.655G>A	c.(655-657)GCC>ACC	p.A219T		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	219	Laminin N-terminal.				apoptosis|axon guidance		protein binding				0						CGGCCTCATCGCCTTCAGCAC	0.701													0	0	0	0.000602	0	5	8										A	8926345	G	A	8926345	3	1	93	1	0	0	0	0	1	0	0	0	10700	1087	38	2	657	2	NTN1	17	8926345	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	907389	8926345	72268865	240	27954										
TRPV2	51393	broad.mit.edu	37	chr17	16327060	16327060	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctcacgcctctgaagctggcCgccaaggagggcaagatcga	13	13	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:16327060C>T	uc002gpy.2	+	5	1270	c.903C>T	c.(901-903)GCC>GCT	p.A301A	TRPV2_uc002gpz.2_Intron	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	301	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 6.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGAAGCTGGCCGCCAAGGAGG	0.597													0	0	0	0.00499	0	16	17										T	16327060	C	T	16327060	2	4	93	1	0	0	0	0	0	0	0	1	16593	639	23	2		2	TRPV2	17	16327060	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	7400715	16327060	64868150	241	27955										
PLD6	201164	broad.mit.edu	37	chr17	17109483	17109483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agacgggaagaacagcgcctCgcgccgcggccgccgccgcc	15	18	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:17109483C>T	uc002gqz.2	-	1	150	c.118G>A	c.(118-120)GAG>AAG	p.E40K	PLD6_uc010cpn.2_Intron	NM_178836	NP_849158	Q8N2A8	PLD6_HUMAN	phospholipase D6	40	Cytoplasmic (Potential).				DNA methylation involved in gamete generation|lipid catabolic process|meiosis|mitochondrial fusion|P granule organization|piRNA metabolic process|spermatid development	integral to membrane|mitochondrial outer membrane	cardiolipin hydrolase activity|protein homodimerization activity				0						AACAGCGCCTcgcgccgcggc	0.667													0	0	0	0.000602	0	5	3										T	17109483	C	T	17109483	3	4	93	1	0	0	0	0	1	0	0	0	12050	893	31	1	648	1	PLD6	17	17109483	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	782423	17109483	64085727	242	27956										
MLLT6	4302	broad.mit.edu	37	chr17	36863784	36863784	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	acggggcattgaagaggactGataatggaggtgaggcgggc	19	5	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:36863784G>A	uc002hqi.3	+	3	248	c.235G>A	c.(235-237)GAT>AAT	p.D79N	MLLT6_uc010wdr.1_Missense_Mutation_p.D79N|MLLT6_uc010cvm.1_Missense_Mutation_p.D79N	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	79					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GAAGAGGACTGATAATGGAGG	0.612			T	MLL	AL								0	0	0	0.010504	0	19	90										A	36863784	G	A	36863784	3	1	93	1	0	0	0	0	1	0	0	0	9630	1290	45	1	245	1	MLLT6	17	36863784	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	19754301	36863784	44331426	243	27957										
CACNB1	782	broad.mit.edu	37	chr17	37331640	37331640	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gggcgtgccgccccctgcagGgtctccaagccctggcccct	13	19	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:37331640G>A	uc002hrm.1	-	14	1756	c.1603C>T	c.(1603-1605)CCT>TCT	p.P535S	CACNB1_uc002hrl.1_Missense_Mutation_p.P307S	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	535					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	CCCCCTGCAGGGTCTCCAAGC	0.657											OREG0024371	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	66	357										A	37331640	G	A	37331640	3	1	93	1	0	0	0	0	1	0	0	0	2552	1232	43	2	197	2	CACNB1	17	37331640	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	467856	37331640	43863570	244	27958										
MED1	5469	broad.mit.edu	37	chr17	37564338	37564338	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tccccacattttttgactctGaggtcttcttagaagaatcc	6	11	3	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:37564338G>A	uc002hrv.3	-	17	4348	c.4136C>T	c.(4135-4137)TCA>TTA	p.S1379L	MED1_uc010wee.1_Missense_Mutation_p.S1207L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1379	Ser-rich.|Interaction with TP53.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTTTGACTCTGAGGTCTTCTT	0.443										HNSCC(31;0.082)			0	0	0	0.01441	0	52	76										A	37564338	G	A	37564338	3	1	93	1	0	0	0	0	1	0	0	0	9425	1294	45	1	613	1	MED1	17	37564338	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	232698	37564338	43630872	245	27959										
MED1	5469	broad.mit.edu	37	chr17	37564821	37564821	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	taggggacttggctttagagGatggaggagttccaggaaca	16	5	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:37564821G>C	uc002hrv.3	-	17	3865	c.3653C>G	c.(3652-3654)TCC>TGC	p.S1218C	MED1_uc010wee.1_Missense_Mutation_p.S1046C|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1218	Ser-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GGCTTTAGAGGATGGAGGAGT	0.478										HNSCC(31;0.082)			0	0	0	0.005524	0	38	30										C	37564821	G	C	37564821	3	2	93	1	0	0	0	0	1	0	0	0	9425	1174	41	1	1096	1	MED1	17	37564821	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	483	37564821	43630389	246	27960										
DCAKD	79877	broad.mit.edu	37	chr17	43112207	43112207	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctggaacacctggatcactGagctcttgcctgaggcaatg	12	11	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:43112207G>A	uc002ihx.2	-	1	303	c.47C>T	c.(46-48)TCA>TTA	p.S16L	DCAKD_uc010daa.1_Missense_Mutation_p.S16L|DCAKD_uc010dab.1_Missense_Mutation_p.S16L|DCAKD_uc002ihy.2_Missense_Mutation_p.S16L	NM_024819	NP_079095	Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	16	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity				0		Prostate(33;0.155)				CTGGATCACTGAGCTCTTGCC	0.612													0	0	0	0.004482	0	8	46										A	43112207	G	A	43112207	3	1	93	1	0	0	0	0	1	0	0	0	4279	1294	45	1	664	1	DCAKD	17	43112207	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	5547386	43112207	38083003	247	27961										
CDC27	996	broad.mit.edu	37	chr17	45199920	45199920	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gatctaaatccatagcccaaGagaaattcatcagggcgagg	10	9	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:45199920G>A	uc002ild.3	-	18	2409	c.2282C>T	c.(2281-2283)TCT>TTT	p.S761F	CDC27_uc002ile.3_Missense_Mutation_p.S767F|CDC27_uc002ilf.3_Missense_Mutation_p.S760F|CDC27_uc010wkp.1_Missense_Mutation_p.S700F|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	761	TPR 9.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						CATAGCCCAAGAGAAATTCAT	0.383													0	0	0	0.012213	0	34	38										A	45199920	G	A	45199920	3	1	93	1	0	0	0	0	1	0	0	0	3066	942	33	1	200	1	CDC27	17	45199920	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2087713	45199920	35995290	248	27962										
DLX3	1747	broad.mit.edu	37	chr17	48068882	48068882	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtgcaggccagatgggtgctCagtacacagccccagggttg	15	11	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:48068882C>T	uc002ipy.2	-	3	1089	c.863G>A	c.(862-864)TGA>TAA	p.*288*		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	288						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GATGGGTGCTCAGTACACAGC	0.642													0	0	0	0.000602	0	5	26										T	48068882	C	T	48068882	2	4	93	1	0	0	0	0	0	0	0	1	4572	837	29	1		1	DLX3	17	48068882	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2868962	48068882	33126328	249	27963										
TOB1	10140	broad.mit.edu	37	chr17	48940478	48940478	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aaaggcattactgtactggaGaggactgaggttaagggggc	16	5	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:48940478G>A	uc002isw.2	-	1	936	c.901C>T	c.(901-903)CTC>TTC	p.L301F	TOB1_uc010wmy.1_Missense_Mutation_p.L301F|TOB1_uc010wmz.1_Missense_Mutation_p.L301F	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	301					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGTACTGGAGAGGACTGAGG	0.413													0	0	0	0.01441	0	43	47										A	48940478	G	A	48940478	3	1	93	1	0	0	0	0	1	0	0	0	16344	942	33	1	140	1	TOB1	17	48940478	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	871596	48940478	32254732	250	27964										
NME1-NME2	654364	broad.mit.edu	37	chr17	49231768	49231768	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctactttagggatcgtctttCaaggcgaggggcctcctatc	11	11	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:49231768C>T	uc002itk.2	+	2	287	c.34C>T	c.(34-36)CAA>TAA	p.Q12*	NME1_uc010dbx.1_Nonsense_Mutation_p.Q12*|NME1_uc002ith.1_Nonsense_Mutation_p.Q12*|NME1_uc002iti.1_Intron|NME1-NME2_uc002itj.2_Intron	NM_002512	NP_002503	P22392	NDKB_HUMAN	nucleoside diphosphate kinase B	Error:Variant_position_missing_in_P22392_after_alignment					cell adhesion|CTP biosynthetic process|GTP biosynthetic process|negative regulation of apoptosis|nucleobase, nucleoside and nucleotide interconversion|positive regulation of epithelial cell proliferation|positive regulation of keratinocyte differentiation|UTP biosynthetic process	cytosol|lamellipodium|nucleus|ruffle	ATP binding|DNA binding|metal ion binding|nucleoside diphosphate kinase activity|protein binding|protein histidine kinase activity|sequence-specific DNA binding transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			GATCGTCTTTCAAGGCGAGGG	0.308													0	0	0	0.003755	0	31	99										T	49231768	C	T	49231768	4	4	93	1	0	0	0	0	0	1	0	0	10490	827	29	1		1	NME1-NME2	17	49231768	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	291290	49231768	31963442	251	27965										
VEZF1	7716	broad.mit.edu	37	chr17	56060115	56060115	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gggtttggtgatgcctccttCatgagacctcacatggtaag	12	9	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:56060115C>T	uc002ivf.1	-	2	816	c.673G>A	c.(673-675)GAA>AAA	p.E225K	VEZF1_uc010dcn.1_Missense_Mutation_p.E69K	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	225					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ATGCCTCCTTCATGAGACCTC	0.408													0	0	0	0.004007	0	16	100										T	56060115	C	T	56060115	3	4	93	1	0	0	0	0	1	0	0	0	17152	835	29	1	912	1	VEZF1	17	56060115	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6828347	56060115	25135095	252	27966										
TBX2	6909	broad.mit.edu	37	chr17	59482604	59482604	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cggacagcgacccggagcctGagcggttgagcgaggagcgt	18	11	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:59482604G>C	uc010wox.1	+	6	1374	c.1093G>C	c.(1093-1095)GAG>CAG	p.E365Q	TBX2_uc002ize.2_3'UTR|TBX2_uc002izg.2_Missense_Mutation_p.E211Q	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	365					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						CCCGGAGCCTGAGCGGTTGAG	0.741													0	0	0	0.000602	0	5	9										C	59482604	G	C	59482604	3	2	93	1	0	0	0	0	1	0	0	0	15652	1291	45	1	1115	1	TBX2	17	59482604	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3422489	59482604	21712606	253	27967										
DDX42	11325	broad.mit.edu	37	chr17	61895626	61895626	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcttttaatcgtgagagcaaGatggagcccaagatggaacc	12	8	0	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:61895626G>C	uc002jbu.2	+	19	2942	c.2685G>C	c.(2683-2685)AAG>AAC	p.K895N	DDX42_uc002jbv.2_Missense_Mutation_p.K895N|DDX42_uc002jbx.2_Missense_Mutation_p.K631N|DDX42_uc002jby.2_Missense_Mutation_p.K441N|DDX42_uc010wps.1_Missense_Mutation_p.K263N	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	895					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						GTGAGAGCAAGATGGAGCCCA	0.547													0	0	0	0.006999	0	43	63										C	61895626	G	C	61895626	3	2	93	1	0	0	0	0	1	0	0	0	4362	933	33	1	2751	1	DDX42	17	61895626	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2413022	61895626	19299584	254	27968										
GPRC5C	55890	broad.mit.edu	37	chr17	72436224	72436224	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	accctgggcctcttctgcctCgtgtttgcctgtgtggtgaa	12	12	2	1	rs148101331		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:72436224C>T	uc002jks.2	+	1	348	c.309C>T	c.(307-309)CTC>CTT	p.L103L	GPRC5C_uc002jkp.2_Silent_p.L148L|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Silent_p.L115L|GPRC5C_uc002jkt.2_Silent_p.L103L|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	103	Helical; Name=2; (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						TCTTCTGCCTCGTGTTTGCCT	0.607													0	0	0	0.00623	0	38	69										T	72436224	C	T	72436224	2	4	93	1	0	0	0	0	0	0	0	1	6726	871	31	1		1	GPRC5C	17	72436224	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	10540598	72436224	8758986	255	27969										
CASKIN2	57513	broad.mit.edu	37	chr17	73503147	73503147	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cattgacagccgcagaggcgCgcagcagcagcctcacaggc	13	15	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:73503147C>T	uc002joc.2	-	5	858	c.308G>A	c.(307-309)CGC>CAC	p.R103H	CASKIN2_uc010wsc.1_Missense_Mutation_p.R21H|CASKIN2_uc002jod.2_Missense_Mutation_p.R103H	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	103	ANK 2.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGCAGAGGCGCGCAGCAGCAG	0.662													0	0	0	0.00308	0	8	20										T	73503147	C	T	73503147	3	4	93	1	0	0	0	0	1	0	0	0	2667	768	27	2	3364	2	CASKIN2	17	73503147	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1066923	73503147	7692063	256	27970										
UBE2O	63893	broad.mit.edu	37	chr17	74388108	74388108	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgggggggcacggctgggtaGatgttggggagctggatgtc	22	5	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:74388108G>A	uc002jrm.3	-	16	3098	c.3033C>T	c.(3031-3033)ATC>ATT	p.I1011I	UBE2O_uc002jrl.3_Silent_p.I615I	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1011							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						CGGCTGGGTAGATGTTGGGGA	0.592													0	0	0	0.00278	0	21	25										A	74388108	G	A	74388108	2	1	93	1	0	0	0	0	0	0	0	1	16865	932	33	1		1	UBE2O	17	74388108	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	884961	74388108	6807102	257	27971										
CBX4	8535	broad.mit.edu	37	chr17	77808594	77808594	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agcctccccctctgccacctCgccggacttgatcttcaccg	7	20	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr17:77808594C>A	uc002jxe.2	-	5	1010	c.847G>T	c.(847-849)GAG>TAG	p.E283*		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	283	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TCTGCCACCTCGCCGGACTTG	0.592											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.25985e-27	0.01441	3.53978e-27	75	103										A	77808594	C	A	77808594	4	1	93	1	0	0	0	0	0	1	0	0	2720	893	31	3	839	3	CBX4	17	77808594	Nonsense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3420486	77808594	3386616	258	27972										
LPIN2	9663	broad.mit.edu	37	chr18	2925292	2925292	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cgtggctcaggggctctgtgGggatggggtccactgtgatg	19	8	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr18:2925292G>A	uc002klo.2	-	14	2107	c.1868C>T	c.(1867-1869)CCC>CTC	p.P623L		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	623					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GGGCTCTGTGGGGATGGGGTC	0.547													0	0	0	0.003755	0	35	111										A	2925292	G	A	2925292	3	1	93	1	0	0	0	0	1	0	0	0	8919	1232	43	2	850	2	LPIN2	18	2925292	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		2925292	75151956	259	27973										
MYO5B	4645	broad.mit.edu	37	chr18	47500848	47500848	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gccagggcgttgcgcgcattGatcacctgctgcagggacat	14	12	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr18:47500848G>C	uc002leb.2	-	10	1482	c.1194C>G	c.(1192-1194)ATC>ATG	p.I398M	MYO5B_uc002lec.1_Missense_Mutation_p.I397M	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	398	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TGCGCGCATTGATCACCTGCT	0.582													0	0	0	0.004656	0	27	29										C	47500848	G	C	47500848	3	2	93	1	0	0	0	0	1	0	0	0	10079	1280	45	1	4476	1	MYO5B	18	47500848	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	44575556	47500848	30576400	260	27974										
ZNF407	55628	broad.mit.edu	37	chr18	72347227	72347227	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctacacgaattcgctgtgatGattgtggcttcttagcagat	10	8	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr18:72347227G>C	uc002llw.2	+	1	4309	c.4252G>C	c.(4252-4254)GAT>CAT	p.D1418H	ZNF407_uc010xfc.1_Missense_Mutation_p.D1418H|ZNF407_uc010dqu.1_Missense_Mutation_p.D1418H|ZNF407_uc002llu.2_Missense_Mutation_p.D1417H	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TCGCTGTGATGATTGTGGCTT	0.438													0	0	0	0.004482	0	9	31										C	72347227	G	C	72347227	3	2	93	1	0	0	0	0	1	0	0	0	17884	1290	45	1	4254	1	ZNF407	18	72347227	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	24846379	72347227	5730021	261	27975										
SH3GL1	6455	broad.mit.edu	37	chr19	4363857	4363857	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aaagtccaggcggcggccctCcagtttcttcaggtggtgct	13	12	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:4363857C>T	uc002maj.2	-	6	590	c.484G>A	c.(484-486)GAG>AAG	p.E162K	SH3GL1_uc002mak.2_Missense_Mutation_p.E98K|SH3GL1_uc010xig.1_Missense_Mutation_p.E114K	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	162	Potential.|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		CGGCGGCCCTCCAGTTTCTTC	0.627			T	MLL	AL								0	0	0	0.003271	0	32	26										T	4363857	C	T	4363857	3	4	93	1	0	0	0	0	1	0	0	0	14250	864	30	1	642	1	SH3GL1	19	4363857	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		4363857	54765126	262	27976										
SH3GL1	6455	broad.mit.edu	37	chr19	4364106	4364106	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tggatctccttcaggtctttCtcgcacaggttctggagggg	13	10	5	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:4364106C>T	uc002maj.2	-	5	550	c.444G>A	c.(442-444)GAG>GAA	p.E148E	SH3GL1_uc002mak.2_Silent_p.E84E|SH3GL1_uc010xig.1_Silent_p.E100E	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	148	Potential.|BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		TCAGGTCTTTCTCGCACAGGT	0.632			T	MLL	AL								0	0	0	0.00333	0	23	15										T	4364106	C	T	4364106	2	4	93	1	0	0	0	0	0	0	0	1	14250	912	32	1		1	SH3GL1	19	4364106	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	249	4364106	54764877	263	27977										
C19orf45	374877	broad.mit.edu	37	chr19	7565879	7565879	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctgccacccgggagccgccGagcctgcagccgccgcccgc	14	21	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:7565879G>T	uc002mgm.2	+	2	312	c.171G>T	c.(169-171)CCG>CCT	p.P57P		NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	57											0						GGGAGCCGCCGAGCCTGCAGC	0.736													1	0	0.00198382	0.001984	0.00206275	7	7										T	7565879	G	T	7565879	2	4	93	1	0	0	0	0	0	0	0	1	1928	1045	37	3		3	C19orf45	19	7565879	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3201773	7565879	51563104	264	27978										
EVI5L	115704	broad.mit.edu	37	chr19	7928478	7928478	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tgtatcctctgtccccgcgcGatgcgcgcttcttccgccgt	10	17	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:7928478G>A	uc002min.2	+	19	2429	c.2275G>A	c.(2275-2277)GAT>AAT	p.D759N	EVI5L_uc010xjz.1_Missense_Mutation_p.D770N	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	759						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GTCCCCGCGCGATGCGCGCTT	0.687													0	0	0	0.010729	0	9	16										A	7928478	G	A	7928478	3	1	93	1	0	0	0	0	1	0	0	0	5290	1058	37	1	2382	1	EVI5L	19	7928478	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	362599	7928478	51200505	265	27979										
ADAMTS10	81794	broad.mit.edu	37	chr19	8654126	8654126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gggaagctggagactctcacCggccccaggtgaggctgggc	17	12	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:8654126C>T	uc002mkj.1	-	18	2432	c.2158G>A	c.(2158-2160)GGG>AGG	p.G720R	ADAMTS10_uc002mki.1_Missense_Mutation_p.G207R|ADAMTS10_uc002mkk.1_Missense_Mutation_p.G352R	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	720	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						AGACTCTCACCGGCCCCAGGT	0.637													0	0	0	0.011902	0	40	38										T	8654126	C	T	8654126	3	4	93	1	0	0	0	0	1	0	0	0	256	666	23	2	1189	2	ADAMTS10	19	8654126	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	725648	8654126	50474857	266	27980										
ADAMTS10	81794	broad.mit.edu	37	chr19	8654344	8654344	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agtcccctccaccttgcattCgccactgacgcaaatgtcca	6	17	0	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:8654344C>T	uc002mkj.1	-	17	2300	c.2026G>A	c.(2026-2028)GAA>AAA	p.E676K	ADAMTS10_uc002mki.1_Missense_Mutation_p.E163K|ADAMTS10_uc002mkk.1_Missense_Mutation_p.E308K	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	676	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						ACCTTGCATTCGCCACTGACG	0.657													0	0	0	0.01441	0	95	84										T	8654344	C	T	8654344	3	4	93	1	0	0	0	0	1	0	0	0	256	893	31	1	1325	1	ADAMTS10	19	8654344	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	218	8654344	50474639	267	27981										
MUC16	94025	broad.mit.edu	37	chr19	9060229	9060229	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	aatggtcatttctgtagattCtgtcttgatgggggaggtag	14	4	4	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:9060229C>T	uc002mkp.2	-	3	27421	c.27217G>A	c.(27217-27219)GAA>AAA	p.E9073K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9075	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGTAGATTCTGTCTTGATG	0.488													0	0	0	0.01441	0	98	74										T	9060229	C	T	9060229	3	4	93	1	0	0	0	0	1	0	0	0	9973	922	32	1	16634	1	MUC16	19	9060229	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	405885	9060229	50068754	268	27982										
ZNF846	162993	broad.mit.edu	37	chr19	9868197	9868197	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ttagatgtttagcaagtgctGaagattgagtgaagtttttc	11	3	0	5			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:9868197G>C	uc002mmb.1	-	6	2087	c.1556C>G	c.(1555-1557)TCA>TGA	p.S519*	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Nonsense_Mutation_p.S390*	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	519	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCAAGTGCTGAAGATTGAGT	0.368													0	0	0	0.010771	0	43	122										C	9868197	G	C	9868197	4	2	93	1	0	0	0	0	0	1	0	0	18189	1294	45	1	49	1	ZNF846	19	9868197	Nonsense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	807968	9868197	49260786	269	27983										
PDE4A	5141	broad.mit.edu	37	chr19	10561309	10561309	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctgggcggccccacccctgtCtgcaaggccacgctgtcagg	13	17	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:10561309C>T	uc002moj.2	+	5	759	c.651C>T	c.(649-651)GTC>GTT	p.V217V	PDE4A_uc002mok.2_Silent_p.V191V|PDE4A_uc002mol.2_Silent_p.V156V|PDE4A_uc002mom.2_5'Flank|PDE4A_uc002mon.2_5'Flank	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	217					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CCACCCCTGTCTGCAAGGCCA	0.672													0	0	0	0.013537	0	10	18										T	10561309	C	T	10561309	2	4	93	1	0	0	0	0	0	0	0	1	11639	900	32	1		1	PDE4A	19	10561309	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	693112	10561309	48567674	270	27984										
SMARCA4	6597	broad.mit.edu	37	chr19	11151989	11151989	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tattgaccctgaaggccatcGaggagggcacgctggaggag	16	9	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:11151989G>A	uc002mqf.3	+	30	4461	c.4177G>A	c.(4177-4179)GAG>AAG	p.E1393K	SMARCA4_uc010dxp.2_Missense_Mutation_p.E1393K|SMARCA4_uc010dxo.2_Missense_Mutation_p.E1425K|SMARCA4_uc010dxq.2_Missense_Mutation_p.E1360K|SMARCA4_uc010dxr.2_Missense_Mutation_p.E1360K|SMARCA4_uc002mqj.3_Missense_Mutation_p.E1363K|SMARCA4_uc010dxs.2_Missense_Mutation_p.E1363K|SMARCA4_uc002mqh.3_Missense_Mutation_p.E483K	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1393					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GAAGGCCATCGAGGAGGGCAC	0.627			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.01441	0	48	48										A	11151989	G	A	11151989	3	1	93	1	0	0	0	0	1	0	0	0	14770	1059	37	1	4400	1	SMARCA4	19	11151989	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	590680	11151989	47976994	271	27985										
ZNF799	90576	broad.mit.edu	37	chr19	12501795	12501795	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cttacactcatatggcttctCtccagcatgagttgttttgt	7	10	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:12501795C>G	uc010dyt.2	-	4	1567	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	473					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TATGGCTTCTCTCCAGCATGA	0.383													0	0	0	0.01441	0	49	95										G	12501795	C	G	12501795	3	3	93	1	0	0	0	0	1	0	0	0	18163	922	32	1	518	1	ZNF799	19	12501795	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1349806	12501795	46627188	272	27986										
AP1M1	8907	broad.mit.edu	37	chr19	16337279	16337279	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agcgagatcgtgggctccatCaagatgcgagtcttcctctc	11	12	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:16337279C>T	uc002ndu.2	+	6	767	c.594C>T	c.(592-594)ATC>ATT	p.I198I	AP1M1_uc002ndv.2_Silent_p.I210I|AP1M1_uc010xpd.1_Silent_p.I198I	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	198	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						TGGGCTCCATCAAGATGCGAG	0.652													0	0	0	0.004482	0	9	4										T	16337279	C	T	16337279	2	4	93	1	0	0	0	0	0	0	0	1	734	816	29	1		1	AP1M1	19	16337279	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	3835484	16337279	42791704	273	27987										
ZNF254	9534	broad.mit.edu	37	chr19	24309978	24309978	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcttttaagcaactctcaacTcttactacacataaaataat	2	10	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:24309978T>C	uc002nru.2	+	4	1310	c.1176T>C	c.(1174-1176)ACT>ACC	p.T392T	ZNF254_uc010xrk.1_Silent_p.T307T	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	392	C2H2-type 7.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AACTCTCAACTCTTACTACAC	0.353													0	0	0	0.001855	0	5	49										C	24309978	T	C	24309978	2	2	93	1	0	0	0	0	0	0	0	1	17795	1538	54	5		5	ZNF254	19	24309978	Silent	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	7972699	24309978	34819005	274	27988										
ZNF536	9745	broad.mit.edu	37	chr19	31039401	31039401	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tggatggtggtgaggagaaaCccagtggcaagtcctcccag	15	9	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:31039401C>G	uc002nsu.1	+	4	3013	c.2875C>G	c.(2875-2877)CCC>GCC	p.P959A	ZNF536_uc010edd.1_Missense_Mutation_p.P959A	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	959					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGAGGAGAAACCCAGTGGCAA	0.577													0	0	0	0.004482	0	9	185										G	31039401	C	G	31039401	3	3	93	1	0	0	0	0	1	0	0	0	17971	507	18	4	2885	4	ZNF536	19	31039401	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6729423	31039401	28089582	275	27989										
ARHGAP33	115703	broad.mit.edu	37	chr19	36279303	36279303	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcccagctggtccctccactCtgagggccagacccgaagct	10	17	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:36279303C>T	uc002obs.1	+	21	3438	c.3353C>T	c.(3352-3354)TCT>TTT	p.S1118F	ARHGAP33_uc002obt.1_Missense_Mutation_p.S1115F|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.S867F	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1279					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						TCCCTCCACTCTGAGGGCCAG	0.632													0	0	0	0.001168	0	6	7										T	36279303	C	T	36279303	3	4	93	1	0	0	0	0	1	0	0	0	882	913	32	1	3918	1	ARHGAP33	19	36279303	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	5239902	36279303	22849680	276	27990										
RYR1	6261	broad.mit.edu	37	chr19	38973699	38973699	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	actaagctatttcctgccgtCttcgtcctgcccacccacca	5	18	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:38973699C>T	uc002oit.2	+	32	4783	c.4653C>T	c.(4651-4653)GTC>GTT	p.V1551V	RYR1_uc002oiu.2_Silent_p.V1551V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1551	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTCCTGCCGTCTTCGTCCTGC	0.587													0	0	0	0.01441	0	81	76										T	38973699	C	T	38973699	2	4	93	1	0	0	0	0	0	0	0	1	13768	900	32	1		1	RYR1	19	38973699	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2694396	38973699	20155284	277	27991										
SAMD4B	55095	broad.mit.edu	37	chr19	39866385	39866385	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtgagtggccgagtccagagGagcttggggcccgggctgct	19	10	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:39866385G>C	uc002olb.2	+	7	1798	c.763G>C	c.(763-765)GAG>CAG	p.E255Q	SAMD4B_uc002ola.2_Missense_Mutation_p.E255Q	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	255							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GAGTCCAGAGGAGCTTGGGGC	0.652													0	0	0	0.01441	0	166	173										C	39866385	G	C	39866385	3	2	93	1	0	0	0	0	1	0	0	0	13822	1175	41	1	773	1	SAMD4B	19	39866385	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	892686	39866385	19262598	278	27992										
SAMD4B	55095	broad.mit.edu	37	chr19	39868175	39868175	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctctgcaggagctgcagcaGatcatcatcactcccatcaa	8	14	5	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:39868175G>C	uc002olb.2	+	10	2190	c.1155G>C	c.(1153-1155)CAG>CAC	p.Q385H	SAMD4B_uc002ola.2_Missense_Mutation_p.Q385H	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	385							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			AGCTGCAGCAGATCATCATCA	0.627													0	0	0	0.01441	0	49	72										C	39868175	G	C	39868175	3	2	93	1	0	0	0	0	1	0	0	0	13822	933	33	1	1177	1	SAMD4B	19	39868175	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1790	39868175	19260808	279	27993										
TMEM145	284339	broad.mit.edu	37	chr19	42827851	42827851	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	caatccgctgacaaggccttCccgcagcacgtctatgggaa	10	14	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:42827851C>T	uc002otk.1	+	14	1363	c.1311C>T	c.(1309-1311)TTC>TTT	p.F437F	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	437						integral to membrane					0		Prostate(69;0.00682)				ACAAGGCCTTCCCGCAGCACG	0.642													0	0	0	0.01441	0	56	75										T	42827851	C	T	42827851	2	4	93	1	0	0	0	0	0	0	0	1	16056	854	30	1		1	TMEM145	19	42827851	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2959676	42827851	16301132	280	27994										
CEACAM8	1088	broad.mit.edu	37	chr19	43097978	43097978	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tagaagaacctccttcccctCtgcagcattggatggcacag	9	13	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:43097978C>T	uc002oud.2	-	2	241	c.139G>A	c.(139-141)GAG>AAG	p.E47K	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	47	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				TCCTTCCCCTCTGCAGCATTG	0.537													0	0	0	0.01441	0	115	126										T	43097978	C	T	43097978	3	4	93	1	0	0	0	0	1	0	0	0	3198	922	32	1	926	1	CEACAM8	19	43097978	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	270127	43097978	16031005	281	27995										
PRKD2	25865	broad.mit.edu	37	chr19	47219391	47219391	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggagcctgcgccctcaccttCtggtccacgatggaacaggc	12	15	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:47219391C>T	uc002pfh.2	-	2	579	c.237G>A	c.(235-237)CAG>CAA	p.Q79Q	PRKD2_uc002pfg.2_5'Flank|PRKD2_uc002pfi.2_Silent_p.Q79Q|PRKD2_uc002pfj.2_Silent_p.Q79Q|PRKD2_uc010xye.1_Silent_p.Q79Q|PRKD2_uc002pfk.2_5'UTR	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	79					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CCCTCACCTTCTGGTCCACGA	0.657													0	0	0	0.01441	0	50	43										T	47219391	C	T	47219391	2	4	93	1	0	0	0	0	0	0	0	1	12519	912	32	1		1	PRKD2	19	47219391	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	4121413	47219391	11909592	282	27996										
SCAF1	58506	broad.mit.edu	37	chr19	50155955	50155955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ccgggagaaggggtctcgtcGgaaggcgctggacgggggtg	22	8	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:50155955G>A	uc002poq.2	+	7	2433	c.2309G>A	c.(2308-2310)CGG>CAG	p.R770Q		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	770	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GGGTCTCGTCGGAAGGCGCTG	0.577													0	0	0	0.009096	0	4	5										A	50155955	G	A	50155955	3	1	93	1	0	0	0	0	1	0	0	0	13868	1116	39	2	2331	2	SCAF1	19	50155955	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	2936564	50155955	8973028	283	27997										
LAIR1	3903	broad.mit.edu	37	chr19	54872615	54872615	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcccggcatttccttcacttActgagtcaatgcggaatctg	9	12	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:54872615A>G	uc002qfk.1	-	3	582	c.272T>C	c.(271-273)GTA>GCA	p.V91A	LAIR1_uc002qfl.1_Missense_Mutation_p.V91A|LAIR1_uc002qfm.1_Missense_Mutation_p.V90A|LAIR1_uc002qfn.1_Missense_Mutation_p.V90A|LAIR1_uc010yex.1_Missense_Mutation_p.V84A|LAIR1_uc002qfo.2_Missense_Mutation_p.V73A	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	91	Extracellular (Potential).|Ig-like C2-type.					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		TCCTTCACTTACTGAGTCAAT	0.498													0	0	0	0.008291	0	9	276										G	54872615	A	G	54872615	3	3	93	1	0	0	0	0	1	0	0	0	8602	391	14	5	623	5	LAIR1	19	54872615	Missense_Mutation	SNP	A	TCGA-G2-A2EF-01A-12D-A18F-08	4716660	54872615	4256368	284	27998										
EPS8L1	54869	broad.mit.edu	37	chr19	55594761	55594761	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cgcaggctggagctgtccccGgaggagggacccccatacag	15	14	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:55594761G>A	uc002qis.3	+	13	1334	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P	EPS8L1_uc010ess.1_Silent_p.P392P|EPS8L1_uc010est.1_Silent_p.P410P|EPS8L1_uc010yfr.1_Silent_p.P346P|EPS8L1_uc010esu.1_RNA|EPS8L1_uc002qiu.2_Silent_p.P283P|EPS8L1_uc002qiv.2_Silent_p.P56P|EPS8L1_uc002qiw.2_Silent_p.P157P	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	410						cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AGCTGTCCCCGGAGGAGGGAC	0.627													0	0	0	0.00623	0	35	32										A	55594761	G	A	55594761	2	1	93	1	0	0	0	0	0	0	0	1	5195	1103	39	2		2	EPS8L1	19	55594761	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	722146	55594761	3534222	285	27999										
TMEM150B	284417	broad.mit.edu	37	chr19	55824272	55824272	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggggaggccggcggggggctGaggctgggccacggctgaac	23	10	0	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:55824272G>A	uc010esw.1	-	8	830	c.657C>T	c.(655-657)CTC>CTT	p.L219L	TMEM150B_uc010yfu.1_Silent_p.L219L|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	219	Cytoplasmic (Potential).					integral to membrane					0						GCGGGGGGCTGAGGCTGGGCC	0.672													0	0	0	0.004482	0	7	13										A	55824272	G	A	55824272	2	1	93	1	0	0	0	0	0	0	0	1	16065	1277	45	1		1	TMEM150B	19	55824272	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	229511	55824272	3304711	286	28000										
ZNF784	147808	broad.mit.edu	37	chr19	56133794	56133794	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cacgtggcaccggctcgggtCcccaccctgcccgcctccct	10	22	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:56133794C>G	uc002qll.1	-	2	309	c.295G>C	c.(295-297)GAC>CAC	p.D99H	ZNF784_uc010etb.1_RNA	NM_203374	NP_976308	Q8NCA9	ZN784_HUMAN	zinc finger protein 784	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGCTCGGGTCCCCACCCTGC	0.726													0	0	0	0.009096	0	4	19										G	56133794	C	G	56133794	3	3	93	1	0	0	0	0	1	0	0	0	18153	855	30	1	680	1	ZNF784	19	56133794	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	309522	56133794	2995189	287	28001										
ZNF548	147694	broad.mit.edu	37	chr19	57908503	57908503	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ctcagagattgctgtaccgtGatgtgatgctggagaatttg	13	6	1	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr19:57908503G>A	uc002qom.2	+	2	353	c.103G>A	c.(103-105)GAT>AAT	p.D35N	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.D38N	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GCTGTACCGTGATGTGATGCT	0.532													0	0	0	0.01441	0	169	425										A	57908503	G	A	57908503	3	1	93	1	0	0	0	0	1	0	0	0	17977	1290	45	1	149	1	ZNF548	19	57908503	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1774709	57908503	1220480	288	28002										
FAM110A	83541	broad.mit.edu	37	chr20	825768	825768	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagctggacctggacatcctCagcagcctcatcgacttgtg	10	14	2	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:825768C>T	uc002wef.1	+	2	657	c.321C>T	c.(319-321)CTC>CTT	p.L107L	FAM110A_uc002weg.1_Silent_p.L107L|FAM110A_uc002weh.1_Silent_p.L107L|FAM110A_uc010fzz.2_RNA	NM_001042353	NP_001035812	Q9BQ89	F110A_HUMAN	hypothetical protein LOC83541	107						microtubule organizing center|spindle pole	protein binding				0						TGGACATCCTCAGCAGCCTCA	0.721													0	0	0	0.010729	0	9	9										T	825768	C	T	825768	2	4	93	1	0	0	0	0	0	0	0	1	5396	813	29	1		1	FAM110A	20	825768	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		825768	62199752	289	28003										
SIRPB2	284759	broad.mit.edu	37	chr20	1456880	1456880	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcctgtggtcttgacatcttCttgcccagggctcctccgag	11	14	3	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:1456880C>T	uc002wfg.2	-	5	1189	c.961G>A	c.(961-963)GAA>AAA	p.E321K	SIRPB2_uc002wfh.3_Missense_Mutation_p.E223K	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	321	Cytoplasmic (Potential).					integral to membrane					0						TTGACATCTTCTTGCCCAGGG	0.597													0	0	0	0.01441	0	65	139										T	1456880	C	T	1456880	3	4	93	1	0	0	0	0	1	0	0	0	14334	922	32	1	71	1	SIRPB2	20	1456880	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	631112	1456880	61568640	290	28004										
NOP56	10528	broad.mit.edu	37	chr20	2635071	2635071	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcccctgaggggttgttcatGaggacctccgcctgctcttg	12	13	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:2635071G>C	uc002wgh.2	+	4	273	c.220G>C	c.(220-222)GAG>CAG	p.E74Q	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'UTR|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	74					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						GGTTGTTCATGAGGACCTCCG	0.542													0	0	0	0.010818	0	31	53										C	2635071	G	C	2635071	3	2	93	1	0	0	0	0	1	0	0	0	10539	1291	45	1	234	1	NOP56	20	2635071	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	1178191	2635071	60390449	291	28005			2	125		3	3	447	N	G	9.985804e-06
NOP56	10528	broad.mit.edu	37	chr20	2635118	2635118	+	Frame_Shift_Del	DEL	G	G	-													0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cacctgccgtccaaaaagaaGaaagtactcttgggagttgg							TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:2635118delG	uc002wgh.2	+	4	320	c.267delG	c.(265-267)AAGfs	p.K89fs	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'UTR|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	89					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						CCAAAAAGAAGAAAGTACTCT	0.537																		45	72	---	---								-	2635118	G	-	2635118	7	5	93	1	0	1	0	1	0	0	0	0	10539	933	33	0	281	0	NOP56	20	2635118	Frame_Shift_Del	DEL	G	TCGA-G2-A2EF-01A-12D-A18F-08	47	2635118	60390402	292	28006			2	125		3	3	447	N	G	9.985804e-06
NOP56	10528	broad.mit.edu	37	chr20	2635517	2635517	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agtttaatgtgaaccgggtgGacaatatgatcatccagtcc	10	8	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:2635517G>C	uc002wgh.2	+	5	546	c.493G>C	c.(493-495)GAC>CAC	p.D165H	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_5'UTR|SNORA51_uc002wgk.1_5'Flank|NOP56_uc002wgm.1_5'Flank|SNORD86_uc010gaq.1_5'Flank|SNORD56_uc010gar.2_5'Flank|SNORD57_uc002wgo.1_5'Flank	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	165					rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						GAACCGGGTGGACAATATGAT	0.502													0	0	0	0.01441	0	132	120										C	2635517	G	C	2635517	3	2	93	1	0	0	0	0	1	0	0	0	10539	1174	41	1	511	1	NOP56	20	2635517	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	399	2635517	60390003	293	28007			2	125		3	3	447	N	G	9.985804e-06
TMX4	56255	broad.mit.edu	37	chr20	7963265	7963265	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cctcctctgatctccgattcTgctctatggagggaagaaag	10	11	4	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:7963265T>A	uc002wmx.1	-	8	816	c.683A>T	c.(682-684)CAG>CTG	p.Q228L		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	228	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane					0						TCTCCGATTCTGCTCTATGGA	0.308													0	0	0	0.00632	0	27	57										A	7963265	T	A	7963265	3	1	93	1	0	0	0	0	1	0	0	0	16266	1580	55	5	370	5	TMX4	20	7963265	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	5327748	7963265	55062255	294	28008										
FLRT3	23767	broad.mit.edu	37	chr20	14307164	14307164	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gggcttggcacatgagcccaCgcacgttgaccttcacaggt	12	13	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:14307164C>T	uc002wov.1	-	3	1456	c.989G>A	c.(988-990)CGT>CAT	p.R330H	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R330H	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	330	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CATGAGCCCACGCACGTTGAC	0.473													0	0	0	0.007835	0	40	124										T	14307164	C	T	14307164	3	4	93	1	0	0	0	0	1	0	0	0	5940	536	19	2	964	2	FLRT3	20	14307164	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	6343899	14307164	48718356	295	28009										
CST9L	128821	broad.mit.edu	37	chr20	23549013	23549013	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tggaaatgccaggcatagatCagcaggatctgggagcctaa	13	8	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:23549013C>T	uc002wtk.3	-	1	374	c.75G>A	c.(73-75)CTG>CTA	p.L25L		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	25						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGGCATAGATCAGCAGGATCT	0.567													0	0	0	0.012213	0	33	21										T	23549013	C	T	23549013	2	4	93	1	0	0	0	0	0	0	0	1	3980	813	29	1		1	CST9L	20	23549013	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	9241849	23549013	39476507	296	28010										
SNTA1	6640	broad.mit.edu	37	chr20	32000163	32000163	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggcctcgcgggtctcggggaGagacaagtagaggagcagtt	18	8	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:32000163G>C	uc002wzd.1	-	5	1251	c.979C>G	c.(979-981)CTC>GTC	p.L327V	SNTA1_uc010zuf.1_Intron	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	327	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GTCTCGGGGAGAGACAAGTAG	0.632													0	0	0	0.004007	0	13	35										C	32000163	G	C	32000163	3	2	93	1	0	0	0	0	1	0	0	0	14871	942	33	1	554	1	SNTA1	20	32000163	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	8451150	32000163	31025357	297	28011										
ITCH	83737	broad.mit.edu	37	chr20	33026353	33026353	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagagtcagtgggaataattCtccatcactctcaaatggtg	10	8	4	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:33026353C>G	uc010geu.1	+	9	911	c.719C>G	c.(718-720)TCT>TGT	p.S240C	ITCH_uc002xak.2_Missense_Mutation_p.S199C|ITCH_uc010zuj.1_Missense_Mutation_p.S89C	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	240					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						GGGAATAATTCTCCATCACTC	0.483													0	0	0	0.01441	0	72	56										G	33026353	C	G	33026353	3	3	93	1	0	0	0	0	1	0	0	0	7868	913	32	1	618	1	ITCH	20	33026353	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1026190	33026353	29999167	298	28012										
RPRD1B	58490	broad.mit.edu	37	chr20	36662412	36662412	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gagctgagcaactctcagcaGagcgtgcagaccctgtccct	11	14	1	3	rs17853182		TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:36662412G>A	uc002xho.3	+	1	465	c.63G>A	c.(61-63)CAG>CAA	p.Q21Q	KIAA0406_uc002xhl.2_5'Flank|KIAA0406_uc002xhm.2_5'Flank	NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	21	CID.			Q -> H (in Ref. 5; AAH33629).						pancreas(1)	1						ACTCTCAGCAGAGCGTGCAGA	0.642													0	0	0	0.01441	0	58	91										A	36662412	G	A	36662412	2	1	93	1	0	0	0	0	0	0	0	1	13616	933	33	1		1	RPRD1B	20	36662412	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3636059	36662412	26363108	299	28013										
ELMO2	63916	broad.mit.edu	37	chr20	45002118	45002118	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcagattccaaagagctcttCaaaggctcggtcatgggtaa	11	9	3	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:45002118C>G	uc002xrt.1	-	16	1546	c.1336G>C	c.(1336-1338)GAA>CAA	p.E446Q	ELMO2_uc010zxq.1_Missense_Mutation_p.E178Q|ELMO2_uc002xrs.1_Missense_Mutation_p.E193Q|ELMO2_uc002xru.1_Missense_Mutation_p.E446Q|ELMO2_uc010zxr.1_Missense_Mutation_p.E458Q|ELMO2_uc010zxs.1_Missense_Mutation_p.E263Q|ELMO2_uc002xrv.1_Missense_Mutation_p.E165Q|ELMO2_uc002xrw.2_Missense_Mutation_p.E263Q	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	446	ELMO.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				AAGAGCTCTTCAAAGGCTCGG	0.502													0	0	0	0.004289	0	39	51										G	45002118	C	G	45002118	3	3	93	1	0	0	0	0	1	0	0	0	5066	835	29	1	854	1	ELMO2	20	45002118	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	8339706	45002118	18023402	300	28014										
SULF2	55959	broad.mit.edu	37	chr20	46313304	46313304	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cagtgtttgtccgggttgggCgcgtagttgtagctcggcgt	17	8	0	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:46313304C>T	uc002xto.2	-	6	1089	c.759G>A	c.(757-759)GCG>GCA	p.A253A	SULF2_uc002xtr.2_Silent_p.A253A|SULF2_uc002xtq.2_Silent_p.A253A	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	253					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCGGGTTGGGCGCGTAGTTGT	0.632													0	0	0	0.00308	0	8	46										T	46313304	C	T	46313304	2	4	93	1	0	0	0	0	0	0	0	1	15370	755	27	2		2	SULF2	20	46313304	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1311186	46313304	16712216	301	28015										
SNAI1	6615	broad.mit.edu	37	chr20	48604577	48604577	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gcaccaagagtccggctgctCaggatgtccccgctgaccct	11	16	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr20:48604577C>T	uc002xuz.2	+	3	849	c.779C>T	c.(778-780)TCA>TTA	p.S260L		NM_005985	NP_005976	O95863	SNAI1_HUMAN	snail 1 homolog	260					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCCGGCTGCTCAGGATGTCCC	0.617													0	0	0	0.005524	0	37	33										T	48604577	C	T	48604577	3	4	93	1	0	0	0	0	1	0	0	0	14826	838	29	1	789	1	SNAI1	20	48604577	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	2291273	48604577	14420943	302	28016										
ADAMTS5	11096	broad.mit.edu	37	chr21	28296403	28296403	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	tcaacaagcattgcttaaacGcagaaggcctttgggagaga	11	8	1	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr21:28296403G>C	uc002ymg.2	-	8	3491	c.2762C>G	c.(2761-2763)GCG>GGG	p.A921G		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	921	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TTGCTTAAACGCAGAAGGCCT	0.483													0	0	0	0.004007	0	15	51										C	28296403	G	C	28296403	3	2	93	1	0	0	0	0	1	0	0	0	269	1087	38	4	34	4	ADAMTS5	21	28296403	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		28296403	19833492	303	28017										
GNB1L	54584	broad.mit.edu	37	chr22	19794230	19794230	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cccagcttggcatctgccttCggcttcagggcgcacactga	11	15	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:19794230C>T	uc002zqe.1	-	5	862	c.468G>A	c.(466-468)CCG>CCA	p.P156P	GNB1L_uc002zqd.1_Silent_p.P12P|GNB1L_uc002zqf.1_Silent_p.P156P	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	156					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					CATCTGCCTTCGGCTTCAGGG	0.622													0	0	0	0.003755	0	29	35										T	19794230	C	T	19794230	2	4	93	1	0	0	0	0	0	0	0	1	6516	871	31	1		1	GNB1L	22	19794230	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08		19794230	31510336	304	28018										
RTDR1	27156	broad.mit.edu	37	chr22	23404081	23404081	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	agatggaccaggatggggatGacgtcaaaatgacacacctg	13	8	1	3			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:23404081G>A	uc002zwt.2	-	6	854	c.696C>T	c.(694-696)GTC>GTT	p.V232V		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	232							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		GGATGGGGATGACGTCAAAAT	0.562													0	0	0	0.007835	0	40	29										A	23404081	G	A	23404081	2	1	93	1	0	0	0	0	0	0	0	1	13719	1277	45	1		1	RTDR1	22	23404081	Silent	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	3609851	23404081	27900485	305	28019										
CABIN1	23523	broad.mit.edu	37	chr22	24472152	24472152	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	cccatgctcccatcctccctCatgctgctgaacacagccca	5	20	1	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:24472152C>A	uc002zzi.1	+	19	2794	c.2667C>A	c.(2665-2667)CTC>CTA	p.L889L	CABIN1_uc002zzj.1_Silent_p.L839L|CABIN1_uc002zzl.1_Silent_p.L889L	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	889					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CATCCTCCCTCATGCTGCTGA	0.587													1	0	6.38683e-12	0.008361	6.80336e-12	26	96										A	24472152	C	A	24472152	2	1	93	1	0	0	0	0	0	0	0	1	2528	813	29	3		3	CABIN1	22	24472152	Silent	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	1068071	24472152	26832414	306	28020										
HSCB	150274	broad.mit.edu	37	chr22	29153094	29153094	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gaagaagccaaggaaattttGacaaagatgagatacttttc	9	5	0	4			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:29153094G>C	uc003aea.2	+	6	686	c.645G>C	c.(643-645)TTG>TTC	p.L215F		NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	215					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						AGGAAATTTTGACAAAGATGA	0.318													0	0	0	0.01441	0	44	98										C	29153094	G	C	29153094	3	2	93	1	0	0	0	0	1	0	0	0	7374	1281	45	1	667	1	HSCB	22	29153094	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	4680942	29153094	22151472	307	28021										
APOL5	80831	broad.mit.edu	37	chr22	36122831	36122831	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtgtgtaaaagctatccaggGcatcaaggatcttcatgcct	10	9	3	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:36122831G>A	uc003aof.2	+	3	716	c.716G>A	c.(715-717)GGC>GAC	p.G239D		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	239					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						GCTATCCAGGGCATCAAGGAT	0.468													0	0	0	0.009096	0	4	178										A	36122831	G	A	36122831	3	1	93	1	0	0	0	0	1	0	0	0	809	1203	42	2	726	2	APOL5	22	36122831	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	6969737	36122831	15181735	308	28022										
TTLL8	164714	broad.mit.edu	37	chr22	50471761	50471761	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtcgaacttggtgtcacagaTgagcagcggcgtctcgatgt	14	9	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chr22:50471761T>G	uc011ark.1	-	10	1153	c.1153A>C	c.(1153-1155)ATC>CTC	p.I385L		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GTGTCACAGATGAGCAGCGGC	0.562													0	0	0	0.004482	0	9	5										G	50471761	T	G	50471761	3	3	93	1	0	0	0	0	1	0	0	0	16730	1464	51	5	1370	5	TTLL8	22	50471761	Missense_Mutation	SNP	T	TCGA-G2-A2EF-01A-12D-A18F-08	14348930	50471761	832805	309	28023										
STS	412	broad.mit.edu	37	chrX	7268123	7268123	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	catccgagccccggttttatGaaatcctcaaagtcatgcag	8	12	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:7268123G>A	uc004cry.3	+	10	1818	c.1573G>A	c.(1573-1575)GAA>AAA	p.E525K		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	525	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CCGGTTTTATGAAATCCTCAA	0.498									Ichthyosis				0	0	0	0.003163	0	15	10										A	7268123	G	A	7268123	3	1	93	1	0	0	0	0	1	0	0	0	15331	1291	45	1	1611	1	STS	23	7268123	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08		7268123	148002437	310	28024										
TAB3	257397	broad.mit.edu	37	chrX	30873150	30873150	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gtggaagaatttgtaaagctCttggtacagtctgtccagaa	11	6	2	2			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:30873150C>G	uc004dcj.2	-	6	1295	c.632G>C	c.(631-633)AGA>ACA	p.R211T	TAB3_uc004dck.2_Missense_Mutation_p.R211T|TAB3_uc010ngl.2_Missense_Mutation_p.R211T	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	211	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						TTGTAAAGCTCTTGGTACAGT	0.423													0	0	0	0.006122	0	18	13										G	30873150	C	G	30873150	3	3	93	1	0	0	0	0	1	0	0	0	15494	913	32	1	1530	1	TAB3	23	30873150	Missense_Mutation	SNP	C	TCGA-G2-A2EF-01A-12D-A18F-08	23605027	30873150	124397410	311	28025										
ZMYM3	9203	broad.mit.edu	37	chrX	70472591	70472591	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	gctcctcctcctgcccagggGagccccttcttgcagtagct	10	17	1	0			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:70472591G>A	uc004dzh.1	-	2	602	c.515C>T	c.(514-516)TCC>TTC	p.S172F	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.S172F|ZMYM3_uc004dzj.1_Missense_Mutation_p.S172F|ZMYM3_uc011mpu.1_5'Flank|ZMYM3_uc004dzk.3_Missense_Mutation_p.S172F|ZMYM3_uc004dzl.3_Missense_Mutation_p.S172F|ZMYM3_uc004dzm.3_Missense_Mutation_p.S172F	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	172					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CTGCCCAGGGGAGCCCCTTCT	0.577													0	0	0	0.00632	0	25	7										A	70472591	G	A	70472591	3	1	93	1	0	0	0	0	1	0	0	0	17698	1174	41	1	3711	1	ZMYM3	23	70472591	Missense_Mutation	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	39599441	70472591	84797969	312	28026										
NONO	4841	broad.mit.edu	37	chrX	70514379	70514379	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.508038585209003	158	7.26527088451636e-61	4.14796523434327	5.21106834258723	3.55593775490202	0.0991292991176406	0.217754357439058	120	ggctccttcctgctaaccacGtaagtgagggtcattttcag	10	11	2	1			TCGA-G2-A2EF-01A-12D-A18F-08	TCGA-G2-A2EF-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5917bd-2cb1-438c-a46c-5d8ca5b2fd0e	f2ba42d5-03bd-4c43-8480-401ab04f73ac	g.chrX:70514379G>A	uc004dzo.2	+	6	1360	c.650_splice	c.e6+1	p.T217_splice	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Splice_Site_p.T217_splice|NONO_uc004dzp.2_Splice_Site_p.T217_splice|NONO_uc011mpv.1_Splice_Site_p.T128_splice|NONO_uc004dzq.2_Splice_Site_p.T86_splice	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding						DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					TGCTAACCACGTAAGTGAGGG	0.473			T	TFE3	papillary renal cancer								0	0	0	0.004482	0	9	1										A	70514379	G	A	70514379	5	1	93	1	0	0	0	0	0	0	1	0	10534	1159	40	2	661	2	NONO	23	70514379	Splice_Site	SNP	G	TCGA-G2-A2EF-01A-12D-A18F-08	41788	70514379	84756181	313	28027										
TTLL10	254173	broad.mit.edu	37	chr1	1120466	1120466	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggcccggggcctcgccaagGactgggtcttcaccaccctc	12	17	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:1120466G>C	uc001acy.2	+	13	1529	c.1378G>C	c.(1378-1380)GAC>CAC	p.D460H	TTLL10_uc010nyg.1_Missense_Mutation_p.D460H|TTLL10_uc001acz.1_Missense_Mutation_p.D387H	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	460	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTCGCCAAGGACTGGGTCTT	0.632													0	0	0	0.000978	0	10	20										C	1120466	G	C	1120466	3	2	94	1	0	0	0	0	1	0	0	0	16720	1174	41	1	1416	1	TTLL10	1	1120466	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		1120466	248130155	1	28028										
CHD5	26038	broad.mit.edu	37	chr1	6206323	6206323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	actctggcttgatgccatagCggtagaagcgctcctccatc	10	13	1	2	rs141210110		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:6206323C>T	uc001amb.1	-	11	1851	c.1751G>A	c.(1750-1752)CGC>CAC	p.R584H	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	584					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GATGCCATAGCGGTAGAAGCG	0.607													0	0	0	0.003954	0	22	66										T	6206323	C	T	6206323	3	4	94	1	0	0	0	0	1	0	0	0	3328	768	27	2	4237	2	CHD5	1	6206323	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5085857	6206323	243044298	2	28029										
SPEN	23013	broad.mit.edu	37	chr1	16255003	16255003	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gattctgagaggaggctttaCagccgatcctcagaccggag	13	10	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:16255003C>G	uc001axk.1	+	11	2472	c.2268C>G	c.(2266-2268)TAC>TAG	p.Y756*	SPEN_uc010obp.1_Nonsense_Mutation_p.Y715*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	756	Arg-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GGAGGCTTTACAGCCGATCCT	0.512													0	0	0	0.004656	0	27	65										G	16255003	C	G	16255003	4	3	94	1	0	0	0	0	0	1	0	0	15037	489	17	4	2310	4	SPEN	1	16255003	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	10048680	16255003	232995618	3	28030										
ZBTB8A	653121	broad.mit.edu	37	chr1	33059171	33059171	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	attaaaaagaccaaacatttGagattgtcacagccttctga	6	8	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:33059171G>C	uc001bvn.2	+	3	1124	c.639G>C	c.(637-639)TTG>TTC	p.L213F	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Missense_Mutation_p.L213F	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCAAACATTTGAGATTGTCAC	0.403													0	0	0	0.000978	0	12	38										C	33059171	G	C	33059171	3	2	94	1	0	0	0	0	1	0	0	0	17553	1281	45	1	641	1	ZBTB8A	1	33059171	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	16804168	33059171	216191450	4	28031										
ZSCAN20	7579	broad.mit.edu	37	chr1	33957212	33957212	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gggatcctgaagaaatggcaGaagactgtaacggtgctggc	15	7	0	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:33957212G>A	uc001bxj.3	+	6	1521	c.1354G>A	c.(1354-1356)GAA>AAA	p.E452K	ZSCAN20_uc001bxk.2_Missense_Mutation_p.E398K|ZSCAN20_uc009vui.2_Missense_Mutation_p.E452K	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	452					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGAAATGGCAGAAGACTGTAA	0.577													0	0	0	0.002445	0	32	55										A	33957212	G	A	33957212	3	1	94	1	0	0	0	0	1	0	0	0	18229	943	33	1	1372	1	ZSCAN20	1	33957212	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	898041	33957212	215293409	5	28032										
C1orf94	84970	broad.mit.edu	37	chr1	34663406	34663406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cccgacctcctcctgcacgtCctgacaagctccctgagctc	7	20	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:34663406C>T	uc001bxs.3	+	2	730	c.331C>T	c.(331-333)CCT>TCT	p.P111S	C1orf94_uc001bxt.2_Missense_Mutation_p.P301S	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	111							protein binding				0		Myeloproliferative disorder(586;0.0393)				TCCTGCACGTCCTGACAAGCT	0.612													0	0	0	0.007413	0	18	40										T	34663406	C	T	34663406	3	4	94	1	0	0	0	0	1	0	0	0	2071	855	30	1	907	1	C1orf94	1	34663406	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	706194	34663406	214587215	6	28033										
ARTN	9048	broad.mit.edu	37	chr1	44402240	44402240	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctgcagcggctcctgccgcCgcgcgcgctctccacacgac	11	20	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:44402240C>T	uc001cks.2	+	5	1248	c.466C>T	c.(466-468)CGC>TGC	p.R156C	ARTN_uc001ckv.2_Missense_Mutation_p.R164C|ARTN_uc001ckt.2_Missense_Mutation_p.R164C|ARTN_uc001cku.2_Missense_Mutation_p.R156C|ARTN_uc001ckw.2_Missense_Mutation_p.R173C	NM_057091	NP_476432	Q5T4W7	ARTN_HUMAN	neurotrophic factor artemin isoform 1 precursor	156					axon guidance|neuroblast proliferation|signal transduction	extracellular region	growth factor activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CTCCTGCCGCCGCGCGCGCTC	0.776													0	0	0	0.000248	0	4	4										T	44402240	C	T	44402240	3	4	94	1	0	0	0	0	1	0	0	0	1001	652	23	2	587	2	ARTN	1	44402240	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	9738834	44402240	204848381	7	28034										
PLK3	1263	broad.mit.edu	37	chr1	45269884	45269884	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtagtggagtcagccctttgTgctctgagaaattgtatagc	12	7	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:45269884T>G	uc001cmn.2	+	11	1408	c.1308T>G	c.(1306-1308)TGT>TGG	p.C436W	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	436						membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					CAGCCCTTTGTGCTCTGAGAA	0.552													0	0	0	0.006122	0	19	35										G	45269884	T	G	45269884	3	3	94	1	0	0	0	0	1	0	0	0	12097	1702	59	5	1350	5	PLK3	1	45269884	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	867644	45269884	203980737	8	28035										
DNAJC6	9829	broad.mit.edu	37	chr1	65874363	65874363	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgattttgaagacctactctCtggtcaaggtttcaatgctc	8	9	3	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:65874363C>G	uc001dcd.1	+	17	2524	c.2360C>G	c.(2359-2361)TCT>TGT	p.S787C	DNAJC6_uc010opc.1_Missense_Mutation_p.S774C|DNAJC6_uc001dce.1_Missense_Mutation_p.S844C	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	787					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						GACCTACTCTCTGGTCAAGGT	0.368													0	0	0	0.001882	0	21	56										G	65874363	C	G	65874363	3	3	94	1	0	0	0	0	1	0	0	0	4653	913	32	1	2426	1	DNAJC6	1	65874363	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	20604479	65874363	183376258	9	28036										
DDAH1	23576	broad.mit.edu	37	chr1	85816110	85816110	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtatttaccttaagggccttCtgtgcagattcactagaccc	8	11	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:85816110C>G	uc001dlb.2	-	4	746	c.585G>C	c.(583-585)CAG>CAC	p.Q195H	DDAH1_uc001dlc.2_Missense_Mutation_p.Q92H|uc001dla.1_Intron|DDAH1_uc010osb.1_Missense_Mutation_p.Q95H|DDAH1_uc009wco.2_Missense_Mutation_p.Q92H	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	195					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	TAAGGGCCTTCTGTGCAGATT	0.502													0	0	0	0.00361	0	49	95										G	85816110	C	G	85816110	3	3	94	1	0	0	0	0	1	0	0	0	4321	912	32	1	284	1	DDAH1	1	85816110	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	19941747	85816110	163434511	10	28037										
RBM15	64783	broad.mit.edu	37	chr1	110882243	110882243	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcccgcggtgagcggagcaaGaagttagggggctctggtgg	19	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:110882243G>A	uc001dzl.1	+	1	299	c.216G>A	c.(214-216)AAG>AAA	p.K72K	RBM15_uc001dzm.1_Silent_p.K72K|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	72	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGCGGAGCAAGAAGTTAGGGG	0.632			T	MKL1	acute megakaryocytic leukemia								0	0	0	0.006122	0	17	26										A	110882243	G	A	110882243	2	1	94	1	0	0	0	0	0	0	0	1	13116	933	33	1		1	RBM15	1	110882243	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	25066133	110882243	138368378	11	28038										
NOTCH2NL	388677	broad.mit.edu	37	chr1	145281697	145281697	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttcacttttgagtgcaactgCcttccaggtaaggagctccc	9	12	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:145281697C>T	uc001emn.3	+	4	997	c.627C>T	c.(625-627)TGC>TGT	p.C209C	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Silent_p.C209C|NOTCH2NL_uc001emo.2_Silent_p.C209C|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	209	EGF-like 6.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						AGTGCAACTGCCTTCCAGGTA	0.542													0	0	0	0.006214	0	9	127										T	145281697	C	T	145281697	2	4	94	1	0	0	0	0	0	0	0	1	10549	747	26	2		2	NOTCH2NL	1	145281697	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	34399454	145281697	103968924	12	28039										
FMO5	2330	broad.mit.edu	37	chr1	146672821	146672821	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aatcaagcctatgattgcaaGagttggcctttccaggttag	10	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:146672821G>C	uc001epi.2	-	7	1485	c.1096C>G	c.(1096-1098)CTT>GTT	p.L366V	FMO5_uc001eph.3_Missense_Mutation_p.L366V|FMO5_uc001epj.2_Intron	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	366						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					ATGATTGCAAGAGTTGGCCTT	0.453													0	0	0	0.00245	0	14	33										C	146672821	G	C	146672821	3	2	94	1	0	0	0	0	1	0	0	0	5958	942	33	1	660	1	FMO5	1	146672821	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1391124	146672821	102577800	13	28040										
FMO5	2330	broad.mit.edu	37	chr1	146672902	146672902	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cactttgacggaatcttccaGaaacggaaagtcaaagctat	8	9	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:146672902G>C	uc001epi.2	-	7	1404	c.1015C>G	c.(1015-1017)CTG>GTG	p.L339V	FMO5_uc001eph.3_Missense_Mutation_p.L339V|FMO5_uc001epj.2_Intron	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	339						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					GAATCTTCCAGAAACGGAAAG	0.448													0	0	0	0.007413	0	18	51										C	146672902	G	C	146672902	3	2	94	1	0	0	0	0	1	0	0	0	5958	933	33	1	741	1	FMO5	1	146672902	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	81	146672902	102577719	14	28041										
ACP6	51205	broad.mit.edu	37	chr1	147124335	147124335	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aatctcttcagcatggggcaGcttgggaggttgtgtgcctg	15	8	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:147124335G>A	uc001epr.2	-	7	1262	c.798C>T	c.(796-798)AGC>AGT	p.S266S	ACP6_uc009wjj.1_3'UTR	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	266					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					GCATGGGGCAGCTTGGGAGGT	0.493													0	0	0	0.003954	0	23	49										A	147124335	G	A	147124335	2	1	94	1	0	0	0	0	0	0	0	1	165	962	34	2		2	ACP6	1	147124335	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	451433	147124335	102126286	15	28042										
MCL1	4170	broad.mit.edu	37	chr1	150551448	150551448	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggcgccggtggcctgctcccGaaggtaccgagagataatct	14	12	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:150551448G>A	uc001euz.2	-	1	689	c.559C>T	c.(559-561)CGG>TGG	p.R187W	MCL1_uc010pch.1_Missense_Mutation_p.R77W|MCL1_uc001eva.2_Missense_Mutation_p.R187W	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	187					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCCTGCTCCCGAAGGTACCGA	0.647													0	0	0	0.003954	0	24	50										A	150551448	G	A	150551448	3	1	94	1	0	0	0	0	1	0	0	0	9384	1057	37	1	516	1	MCL1	1	150551448	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3427113	150551448	98699173	16	28043										
TNFAIP8L2	79626	broad.mit.edu	37	chr1	151131260	151131260	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtcgctctgtggctcatctCttcatagatgagacaagcag	11	10	4	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:151131260C>G	uc001ewx.2	+	2	213	c.87C>G	c.(85-87)CTC>CTG	p.L29L		NM_024575	NP_078851	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein	29					innate immune response						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGGCTCATCTCTTCATAGATG	0.567													0	0	0	0.004656	0	24	34										G	151131260	C	G	151131260	2	3	94	1	0	0	0	0	0	0	0	1	16275	900	32	1		1	TNFAIP8L2	1	151131260	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	579812	151131260	98119361	17	28044										
HRNR	388697	broad.mit.edu	37	chr1	152188523	152188523	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	actgacctgagccagacccaTgtcggccactgctggaagac	11	14	0	4	rs140946102		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:152188523T>C	uc001ezt.1	-	3	5658	c.5582A>G	c.(5581-5583)CAT>CGT	p.H1861R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1861	20.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGACCCATGTCGGCCACT	0.592													0	0	0	0.00361	0	46	519										C	152188523	T	C	152188523	3	2	94	1	0	0	0	0	1	0	0	0	7359	1464	51	5	2974	5	HRNR	1	152188523	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	1057263	152188523	97062098	18	28045										
IVL	3713	broad.mit.edu	37	chr1	152882414	152882414	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctcccccatgccagaaggtGcctgtcgagctcccagtgga	11	16	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:152882414G>A	uc001fau.2	+	2	187	c.141G>A	c.(139-141)GTG>GTA	p.V47V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	47					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCAGAAGGTGCCTGTCGAGC	0.502													0	0	0	0.004482	0	7	44										A	152882414	G	A	152882414	2	1	94	1	0	0	0	0	0	0	0	1	7929	1306	46	2		2	IVL	1	152882414	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	693891	152882414	96368207	19	28046										
YY1AP1	55249	broad.mit.edu	37	chr1	155649255	155649255	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctcagccacacgctcctcctCttctgggccatcatcttcca	5	19	5	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:155649255C>T	uc001fln.2	-	4	292	c.268G>A	c.(268-270)GAG>AAG	p.E90K	YY1AP1_uc010pgg.1_5'Flank|YY1AP1_uc010pgh.1_Missense_Mutation_p.E13K|YY1AP1_uc010pgi.1_Missense_Mutation_p.E162K|YY1AP1_uc001flh.2_Missense_Mutation_p.E162K|YY1AP1_uc009wqt.2_Missense_Mutation_p.E13K|YY1AP1_uc001flk.2_Missense_Mutation_p.E13K|YY1AP1_uc001fll.2_Missense_Mutation_p.E24K|YY1AP1_uc009wqv.2_5'UTR|YY1AP1_uc001flm.2_Missense_Mutation_p.E13K|YY1AP1_uc001fli.2_Missense_Mutation_p.E24K|YY1AP1_uc009wqu.2_5'UTR|YY1AP1_uc001flj.2_Missense_Mutation_p.E24K|YY1AP1_uc009wqw.2_Missense_Mutation_p.E13K|YY1AP1_uc001flo.2_5'UTR|YY1AP1_uc001flp.2_Missense_Mutation_p.E24K|YY1AP1_uc010pgj.1_Missense_Mutation_p.E90K|YY1AP1_uc009wqx.2_Missense_Mutation_p.E162K|YY1AP1_uc010pgk.1_Missense_Mutation_p.E162K	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	90					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CGCTCCTCCTCTTCTGGGCCA	0.483													0	0	0	0.003163	0	16	52										T	155649255	C	T	155649255	3	4	94	1	0	0	0	0	1	0	0	0	17505	922	32	1	2214	1	YY1AP1	1	155649255	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2766841	155649255	93601366	20	28047										
RGL1	23179	broad.mit.edu	37	chr1	183853949	183853949	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaacatttggctcctacgatCcgtgccaccatctctcagtt	6	14	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:183853949C>T	uc001gqo.2	+	7	985	c.828C>T	c.(826-828)ATC>ATT	p.I276I	RGL1_uc010pof.1_Silent_p.I81I|RGL1_uc001gqm.2_Silent_p.I311I|RGL1_uc010pog.1_Silent_p.I274I|RGL1_uc010poh.1_Silent_p.I274I|RGL1_uc010poi.1_Silent_p.I276I	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	276	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CTCCTACGATCCGTGCCACCA	0.478													0	0	0	0.007413	0	19	39										T	183853949	C	T	183853949	2	4	94	1	0	0	0	0	0	0	0	1	13276	845	30	1		1	RGL1	1	183853949	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	28204694	183853949	65396672	21	28048										
PRG4	10216	broad.mit.edu	37	chr1	186280724	186280724	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaatctgtgtattttttcaaGagaggtatgtgttacataat	9	3	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:186280724G>C	uc001gru.3	+	10	3840	c.3789G>C	c.(3787-3789)AAG>AAC	p.K1263N	PRG4_uc001grt.3_Missense_Mutation_p.K1222N|PRG4_uc009wyl.2_Missense_Mutation_p.K1170N|PRG4_uc009wym.2_Missense_Mutation_p.K1129N|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1263					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ATTTTTTCAAGAGAGGTATGT	0.313													0	0	0	0.003954	0	23	44										C	186280724	G	C	186280724	3	2	94	1	0	0	0	0	1	0	0	0	12481	933	33	1	3823	1	PRG4	1	186280724	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2426775	186280724	62969897	22	28049										
PTPRC	5788	broad.mit.edu	37	chr1	198668734	198668734	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctcaccttcccacgcacgcaGactcgcagacgccctctgct	7	20	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:198668734G>A	uc001gur.1	+	5	514	c.334G>A	c.(334-336)GAC>AAC	p.D112N	PTPRC_uc001gus.1_Missense_Mutation_p.D112N|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.D48N|PTPRC_uc009wzf.1_Missense_Mutation_p.D48N|PTPRC_uc010ppg.1_Missense_Mutation_p.D48N|PTPRC_uc001guu.1_Missense_Mutation_p.D155N|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	112	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CACGCACGCAGACTCGCAGAC	0.527											OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00623	0	40	97										A	198668734	G	A	198668734	3	1	94	1	0	0	0	0	1	0	0	0	12797	942	33	1	359	1	PTPRC	1	198668734	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	12388010	198668734	50581887	23	28050										
KIF14	9928	broad.mit.edu	37	chr1	200550392	200550392	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggcttcctgaatcatcattGagagtttcatagagctccaa	8	9	3	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:200550392G>A	uc010ppk.1	-	20	3711	c.3272C>T	c.(3271-3273)TCA>TTA	p.S1091L	KIF14_uc010ppj.1_Missense_Mutation_p.S600L	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1091	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						AATCATCATTGAGAGTTTCAT	0.328													0	0	0	0.00361	0	45	79										A	200550392	G	A	200550392	3	1	94	1	0	0	0	0	1	0	0	0	8276	1294	45	1	1718	1	KIF14	1	200550392	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1881658	200550392	48700229	24	28051										
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200709041	200709062	+	Frame_Shift_Del	DEL	GGGCCAAAATCGCCTGCAATCT	GGGCCAAAATCGCCTGCAATCT	-													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgaccactatgatttctccaGggccaaaatcgcctgcaatc							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:200709041_200709062delGGGCCAAAATCGCCTGCAATCT	uc001gvl.2	+	1	356_377	c.86_107delGGGCCAAAATCGCCTGCAATCT	c.(85-108)AGGGCCAAAATCGCCTGCAATCTGfs	p.R29fs	CAMSAP1L1_uc001gvk.2_Frame_Shift_Del_p.R29fs|CAMSAP1L1_uc001gvm.2_Frame_Shift_Del_p.R29fs	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	29_36						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GATTTCTCCAGGGCCAAAATCGCCTGCAATCTGGCCTGGCTG	0.55																		8	71	---	---								-	200709062	GGGCCAAAATCGCCTGCAATCT	-	200709041	7	5	94	1	0	1	0	1	0	0	0	0	2612	1000	35	0	88	0	CAMSAP1L1	1	200709041	Frame_Shift_Del	DEL	GGGCCAAAATCGCCTGCAATCT	TCGA-G2-A2EJ-01A-11D-A17V-08	158649	200709041	48541580	25	28052										
PHLDA3	23612	broad.mit.edu	37	chr1	201437713	201437713	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgtgaagtagatgtggcgccCggtgctctccacgcactcca	12	14	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:201437713C>A	uc001gwq.2	-	1	587	c.202G>T	c.(202-204)GGG>TGG	p.G68W	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	68	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						ATGTGGCGCCCGGTGCTCTCC	0.687													1	0	0.00307968	0.00308	0.00528666	7	80										A	201437713	C	A	201437713	3	1	94	1	0	0	0	0	1	0	0	0	11850	652	23	4	185	4	PHLDA3	1	201437713	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	728672	201437713	47812908	26	28053										
PPFIA4	8497	broad.mit.edu	37	chr1	203015064	203015064	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcaacatccatccatgacctCaatgacaagctggagaatga	8	11	1	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:203015064C>G	uc009xaj.2	+	12	1395	c.1395C>G	c.(1393-1395)CTC>CTG	p.L465L	PPFIA4_uc010pqf.1_Silent_p.L25L			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TCCATGACCTCAATGACAAGC	0.587													0	0	0	0.004289	0	37	103										G	203015064	C	G	203015064	2	3	94	1	0	0	0	0	0	0	0	1	12312	841	29	1		1	PPFIA4	1	203015064	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1577351	203015064	46235557	27	28054										
PPP2R5A	5525	broad.mit.edu	37	chr1	212530372	212530372	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaaattgaagagccacttttCaagcagatatccaagtgtgt	8	7	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:212530372C>G	uc001hjb.2	+	10	1633	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	PPP2R5A_uc010ptd.1_Missense_Mutation_p.F294L	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	353					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		AGCCACTTTTCAAGCAGATAT	0.308													0	0	0	0.00333	0	24	46										G	212530372	C	G	212530372	3	3	94	1	0	0	0	0	1	0	0	0	12392	825	29	1	1097	1	PPP2R5A	1	212530372	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	9515308	212530372	36720249	28	28055										
TTC13	79573	broad.mit.edu	37	chr1	231051946	231051946	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaagcgcacatacttgtctcCtgtaatcgtgattgtgaatc	9	9	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:231051946C>T	uc001huf.3	-	18	2117	c.2086G>A	c.(2086-2088)GGA>AGA	p.G696R	TTC13_uc009xfi.2_Missense_Mutation_p.G643R|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.G642R|TTC13_uc009xfk.1_Missense_Mutation_p.G585R	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	696							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TACTTGTCTCCTGTAATCGTG	0.428													0	0	0	0.00623	0	39	103										T	231051946	C	T	231051946	3	4	94	1	0	0	0	0	1	0	0	0	16677	690	24	2	520	2	TTC13	1	231051946	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	18521574	231051946	18198675	29	28056										
RYR2	6262	broad.mit.edu	37	chr1	237838043	237838043	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcttccagaggatttaaggaCctggaactggacacgccttc	10	11	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:237838043C>G	uc001hyl.1	+	60	8847	c.8727C>G	c.(8725-8727)GAC>GAG	p.D2909E	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2909	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATTTAAGGACCTGGAACTGG	0.378													0	0	0	0.000602	0	5	19										G	237838043	C	G	237838043	3	3	94	1	0	0	0	0	1	0	0	0	13769	506	18	4	8965	4	RYR2	1	237838043	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	6786097	237838043	11412578	30	28057										
CHRM3	1131	broad.mit.edu	37	chr1	240072502	240072502	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtcggtcatttttcacaagcGcgcacccgagcaggccttgt	11	13	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:240072502G>A	uc001hyp.2	+	5	2530	c.1751G>A	c.(1750-1752)CGC>CAC	p.R584H		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	584	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TTTCACAAGCGCGCACCCGAG	0.522													0	0	0	0.001368	0	12	47										A	240072502	G	A	240072502	3	1	94	1	0	0	0	0	1	0	0	0	3378	1087	38	2	1753	2	CHRM3	1	240072502	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2234459	240072502	9178119	31	28058										
ADAM17	6868	broad.mit.edu	37	chr2	9642368	9642368	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcacttcttctgggcagtctCaaactgacagtttttacagc	8	11	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:9642368C>T	uc002qzu.2	-	13	1765	c.1582G>A	c.(1582-1584)GAG>AAG	p.E528K	ADAM17_uc010ewy.2_Missense_Mutation_p.E528K|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	528	Disintegrin.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TGGGCAGTCTCAAACTGACAG	0.468													0	0	0	0.00361	0	57	123										T	9642368	C	T	9642368	3	4	94	1	0	0	0	0	1	0	0	0	238	835	29	1	920	1	ADAM17	2	9642368	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		9642368	233557005	32	28059										
NOL10	79954	broad.mit.edu	37	chr2	10712233	10712233	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctcttttgtgtcttgacttCaggtgtccggccgaacgacg	11	12	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:10712233C>T	uc002raq.2	-	21	2156	c.2031G>A	c.(2029-2031)CTG>CTA	p.L677L	NOL10_uc010yje.1_Silent_p.L651L|NOL10_uc010yjf.1_Silent_p.L627L|NOL10_uc002rap.2_Silent_p.L627L	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	677						nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		GTCTTGACTTCAGGTGTCCGG	0.478													0	0	0	0.00361	0	88	203										T	10712233	C	T	10712233	2	4	94	1	0	0	0	0	0	0	0	1	10520	813	29	1		1	NOL10	2	10712233	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1069865	10712233	232487140	33	28060										
APOB	338	broad.mit.edu	37	chr2	21228217	21228217	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcgatcttgttggctactgcAtttagatccaaagcagcaat	9	9	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:21228217A>G	uc002red.2	-	26	11651	c.11523T>C	c.(11521-11523)AAT>AAC	p.N3841N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3841					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGCTACTGCATTTAGATCCA	0.458													0	0	0	0.003271	0	32	71										G	21228217	A	G	21228217	2	3	94	1	0	0	0	0	0	0	0	1	785	214	8	5		5	APOB	2	21228217	Silent	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	10515984	21228217	221971156	34	28061										
CIB4	130106	broad.mit.edu	37	chr2	26806690	26806690	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tccatcaggaggtcctcagaCatgtcatcactgttcagcag	9	12	5	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:26806690C>A	uc002rhm.2	-	5	434	c.405G>T	c.(403-405)ATG>ATT	p.M135I		NM_001029881	NP_001025052	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	135							calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTCCTCAGACATGTCATCAC	0.567													1	0	7.41945e-09	0.005443	1.34283e-08	22	69										A	26806690	C	A	26806690	3	1	94	1	0	0	0	0	1	0	0	0	3423	478	17	4	164	4	CIB4	2	26806690	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5578473	26806690	216392683	35	28062										
DPYSL5	56896	broad.mit.edu	37	chr2	27162914	27162914	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cccagtgacactctgaacatCgtggcatcagatcaccggcc	9	15	3	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:27162914C>T	uc002rhu.3	+	9	1121	c.963C>T	c.(961-963)ATC>ATT	p.I321I	DPYSL5_uc002rhv.3_Silent_p.I321I	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	321					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCTGAACATCGTGGCATCAG	0.527													0	0	0	0.007835	0	36	87										T	27162914	C	T	27162914	2	4	94	1	0	0	0	0	0	0	0	1	4750	874	31	1		1	DPYSL5	2	27162914	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	356224	27162914	216036459	36	28063										
SLC30A6	55676	broad.mit.edu	37	chr2	32419022	32419022	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgttcacgatgctttctattCggaataaaccttttgcttat	6	8	2	0	rs148435831		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:32419022C>G	uc002roe.1	+	8	503	c.466C>G	c.(466-468)CGG>GGG	p.R156G	SLC30A6_uc002rof.1_Missense_Mutation_p.R196G|SLC30A6_uc010ymw.1_Missense_Mutation_p.R127G|SLC30A6_uc010ezr.1_Missense_Mutation_p.R156G|SLC30A6_uc002rog.1_5'UTR|SLC30A6_uc010ezs.1_Missense_Mutation_p.R82G|SLC30A6_uc002roh.1_5'UTR	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	156	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GCTTTCTATTCGGAATAAACC	0.303													0	0	0	0.002836	0	29	87										G	32419022	C	G	32419022	3	3	94	1	0	0	0	0	1	0	0	0	14559	875	31	1	496	1	SLC30A6	2	32419022	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5256108	32419022	210780351	37	28064										
CEBPZ	10153	broad.mit.edu	37	chr2	37441016	37441016	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaacaaattaccaatcagctCttcaaattcttcatcatcca	1	12	6	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:37441016C>G	uc002rpz.2	-	10	2566	c.2536G>C	c.(2536-2538)GAG>CAG	p.E846Q		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	846					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				CCAATCAGCTCTTCAAATTCT	0.318													0	0	0	0.000978	0	12	16										G	37441016	C	G	37441016	3	3	94	1	0	0	0	0	1	0	0	0	3204	922	32	1	656	1	CEBPZ	2	37441016	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5021994	37441016	205758357	38	28065										
EPAS1	2034	broad.mit.edu	37	chr2	46583348	46583348	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagatggacaacttgtacctGaaagccttggagggtttcat	11	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:46583348G>A	uc002ruv.2	+	3	764	c.276G>A	c.(274-276)CTG>CTA	p.L92L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	92	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACTTGTACCTGAAAGCCTTGG	0.517													0	0	0	0.00278	0	22	57										A	46583348	G	A	46583348	2	1	94	1	0	0	0	0	0	0	0	1	5150	1277	45	1		1	EPAS1	2	46583348	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9142332	46583348	196616025	39	28066										
EPAS1	2034	broad.mit.edu	37	chr2	46583934	46583934	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaggagattcgtgagaacctGagtctcaaaaatggtatcct	11	7	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:46583934G>C	uc002ruv.2	+	4	929	c.441G>C	c.(439-441)CTG>CTC	p.L147L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	147	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GTGAGAACCTGAGTCTCAAAA	0.458													0	0	0	0.00499	0	16	33										C	46583934	G	C	46583934	2	2	94	1	0	0	0	0	0	0	0	1	5150	1277	45	1		1	EPAS1	2	46583934	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	586	46583934	196615439	40	28067										
GPR75	10936	broad.mit.edu	37	chr2	54080793	54080793	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaagggtttaatcctgacttGaaaaatataagagtaaatcc	7	5	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:54080793G>A	uc002rxo.3	-	2	1372	c.1101C>T	c.(1099-1101)TTC>TTT	p.F367F	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	367	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATCCTGACTTGAAAAATATAA	0.428													0	0	0	0.001855	0	14	57										A	54080793	G	A	54080793	2	1	94	1	0	0	0	0	0	0	0	1	6708	1281	45	1		1	GPR75	2	54080793	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7496859	54080793	189118580	41	28068										
EHBP1	23301	broad.mit.edu	37	chr2	63175857	63175857	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agaagtctcagcagagctctGgaaggacttcaggatctgat	12	8	4	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:63175857G>A	uc002sby.2	+	14	2463	c.1981G>A	c.(1981-1983)GGA>AGA	p.G661R	EHBP1_uc010fcp.2_Missense_Mutation_p.G626R|EHBP1_uc002sbz.2_Missense_Mutation_p.G626R|EHBP1_uc002scb.2_Missense_Mutation_p.G626R	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	661						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GCAGAGCTCTGGAAGGACTTC	0.468									Hereditary_Prostate_Cancer				0	0	0	0.004007	0	17	24										A	63175857	G	A	63175857	3	1	94	1	0	0	0	0	1	0	0	0	4975	1349	47	2	2031	2	EHBP1	2	63175857	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9095064	63175857	180023516	42	28069										
SFTPB	6439	broad.mit.edu	37	chr2	85890579	85890579	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggacatgcagaggtggcactCagagtctcgcggcagccatt	14	11	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:85890579C>T	uc002sqh.2	-	8	898	c.892G>A	c.(892-894)GAG>AAG	p.E298K	SFTPB_uc002sqi.2_Missense_Mutation_p.E306K|SFTPB_uc002sqj.2_Missense_Mutation_p.E298K|SFTPB_uc010ysw.1_5'Flank	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	298	Saposin B-type 3.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						AGGTGGCACTCAGAGTCTCGC	0.612													0	0	0	0.004007	0	14	28										T	85890579	C	T	85890579	3	4	94	1	0	0	0	0	1	0	0	0	14191	835	29	1	265	1	SFTPB	2	85890579	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	22714722	85890579	157308794	43	28070										
ANKRD36	375248	broad.mit.edu	37	chr2	97875579	97875580	+	Frame_Shift_Ins	INS	-	-	A													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgttttgtatatagccagagINSaaaaaaaggatggagaaaaa							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:97875579_97875580insA	uc010yva.1	+	56	3581_3582	c.3337_3338insA	c.(3337-3339)GAAfs	p.E1113fs		NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1113											0						TATAGCCAGAGAAAAAAAGGAT	0.317																		4	6	---	---								A	97875580	-	A	97875579	7	5	94	1	0	1	1	0	0	0	0	0	665	943	33	0	3559	0	ANKRD36	2	97875579	Frame_Shift_Ins	INS	-	TCGA-G2-A2EJ-01A-11D-A17V-08	11985000	97875579	145323794	44	28071										
AFF3	3899	broad.mit.edu	37	chr2	100170988	100170988	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagacatgggggatggggttCcagtgctcctggaaggggag	20	6	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:100170988C>T	uc002tag.2	-	23	3580	c.3344G>A	c.(3343-3345)GGA>GAA	p.G1115E	AFF3_uc002taf.2_Missense_Mutation_p.G1140E	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1115					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGATGGGGTTCCAGTGCTCCT	0.652													0	0	0	0.000248	0	4	7										T	100170988	C	T	100170988	3	4	94	1	0	0	0	0	1	0	0	0	358	855	30	1	344	1	AFF3	2	100170988	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2295409	100170988	143028385	45	28072										
CCDC138	165055	broad.mit.edu	37	chr2	109411023	109411023	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gccaactaatacgacctcatCgagacctcggactgagtgtt	9	12	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:109411023C>G	uc002ten.1	+	5	482	c.422C>G	c.(421-423)TCG>TGG	p.S141W	CCDC138_uc002teo.1_Missense_Mutation_p.S141W|CCDC138_uc002tep.1_Translation_Start_Site|CCDC138_uc010fjm.1_Translation_Start_Site	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	141											0						ACGACCTCATCGAGACCTCGG	0.383													0	0	0	0.004289	0	32	58										G	109411023	C	G	109411023	3	3	94	1	0	0	0	0	1	0	0	0	2772	893	31	1	440	1	CCDC138	2	109411023	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	9240035	109411023	133788350	46	28073										
MERTK	10461	broad.mit.edu	37	chr2	112705072	112705072	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcccgcctgagcccgtcaacAttttctgggttcaaaacagt	9	13	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:112705072A>G	uc002thk.1	+	4	807	c.685A>G	c.(685-687)ATT>GTT	p.I229V	MERTK_uc002thl.1_Missense_Mutation_p.I53V	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	229	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GCCCGTCAACATTTTCTGGGT	0.507													0	0	0	0.007413	0	19	56										G	112705072	A	G	112705072	3	3	94	1	0	0	0	0	1	0	0	0	9479	217	8	5	699	5	MERTK	2	112705072	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	3294049	112705072	130494301	47	28074										
IWS1	55677	broad.mit.edu	37	chr2	128255777	128255777	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgcttcttttacctgtgtttCacctttttcttcttccagat	4	11	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:128255777C>A	uc002ton.2	-	6	1807	c.1504G>T	c.(1504-1506)GAA>TAA	p.E502*	IWS1_uc010yzl.1_Intron	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	502	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		ACCTGTGTTTCACCTTTTTCT	0.299													1	0	2.39556e-15	0.00278	4.50243e-15	23	61										A	128255777	C	A	128255777	4	1	94	1	0	0	0	0	0	1	0	0	7931	835	29	3	991	3	IWS1	2	128255777	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	15550705	128255777	114943596	48	28075										
SCN9A	6335	broad.mit.edu	37	chr2	167168028	167168028	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctttttgtctgcatagtagGggtccaagtcctccaggggc	12	11	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:167168028G>A	uc010fpl.2	-	2	580	c.239C>T	c.(238-240)CCC>CTC	p.P80L		NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	80						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCATAGTAGGGGTCCAAGTC	0.448													0	0	0	0.005524	0	38	28										A	167168028	G	A	167168028	3	1	94	1	0	0	0	0	1	0	0	0	13925	1232	43	2	5798	2	SCN9A	2	167168028	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	38912251	167168028	76031345	49	28076										
TTN	7273	broad.mit.edu	37	chr2	179431057	179431057	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caccagctcttacaacaattCcttttcttaattcggagtca	4	12	3	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:179431057C>A	uc010zfg.1	-	275	72322	c.72098G>T	c.(72097-72099)GGA>GTA	p.G24033V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G17728V|TTN_uc010zfi.1_Missense_Mutation_p.G17661V|TTN_uc010zfj.1_Missense_Mutation_p.G17536V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24960							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAACAATTCCTTTTCTTAA	0.438													1	0	2.73381e-35	0.00361	5.25953e-35	55	127										A	179431057	C	A	179431057	3	1	94	1	0	0	0	0	1	0	0	0	16732	855	30	3	28325	3	TTN	2	179431057	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	12263029	179431057	63768316	50	28077										
TTN	7273	broad.mit.edu	37	chr2	179622543	179622543	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgaggcttgacagaggctgGatgaagctgggcttttggcc	16	8	0	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:179622543G>T	uc010zfi.1	-	44	10490	c.10266C>A	c.(10264-10266)ATC>ATA	p.I3422I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133432	NP_597676	Q8WZ42	TITIN_HUMAN	titin isoform novex-1	3506							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGAGGCTGGATGAAGCTGG	0.458													1	0	1.21457e-23	0.00361	2.30643e-23	86	62										T	179622543	G	T	179622543	2	4	94	1	0	0	0	0	0	0	0	1	16732	1164	41	3		3	TTN	2	179622543	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	191486	179622543	63576830	51	28078										
DNAH7	56171	broad.mit.edu	37	chr2	196698996	196698996	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggttcactaagtttaatcaCataaagactattggcttttt	6	6	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:196698996C>A	uc002utj.3	-	48	9135	c.9034G>T	c.(9034-9036)GTG>TTG	p.V3012L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3012	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGTTTAATCACATAAAGACTA	0.383													1	0	3.11337e-16	0.002836	5.86659e-16	35	14										A	196698996	C	A	196698996	3	1	94	1	0	0	0	0	1	0	0	0	4606	478	17	4	3112	4	DNAH7	2	196698996	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	17076453	196698996	46500377	52	28079										
ABCA12	26154	broad.mit.edu	37	chr2	215875186	215875186	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtctttataaagggagaagcAaaatggtgctggaaggaaaa	13	3	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:215875186A>G	uc002vew.2	-	18	2561	c.2341T>C	c.(2341-2343)TGC>CGC	p.C781R	ABCA12_uc002vev.2_Missense_Mutation_p.C463R|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	781					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGGGAGAAGCAAAATGGTGCT	0.368													0	0	0	0.00245	0	14	11										G	215875186	A	G	215875186	3	3	94	1	0	0	0	0	1	0	0	0	30	130	5	5	5590	5	ABCA12	2	215875186	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	19176190	215875186	27324187	53	28080										
HDLBP	3069	broad.mit.edu	37	chr2	242186257	242186257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atggtctctgaattgctattCtctgctggaaggtcgatttt	10	7	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:242186257C>G	uc002waz.2	-	16	2088	c.1860G>C	c.(1858-1860)GAG>GAC	p.E620D	HDLBP_uc002wba.2_Missense_Mutation_p.E620D|HDLBP_uc002wbb.2_Missense_Mutation_p.E572D	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	620	KH 7.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AATTGCTATTCTCTGCTGGAA	0.488													0	0	0	0.00361	0	61	144										G	242186257	C	G	242186257	3	3	94	1	0	0	0	0	1	0	0	0	7025	912	32	1	1998	1	HDLBP	2	242186257	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	26311071	242186257	1013116	54	28081										
CCR3	1232	broad.mit.edu	37	chr3	46306696	46306696	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gacctttggtaccacatcctActatgatgacgtgggcctgc	10	12	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:46306696A>G	uc003cpg.1	+	4	590	c.47A>G	c.(46-48)TAC>TGC	p.Y16C	CCR3_uc003cpi.1_Missense_Mutation_p.Y16C|CCR3_uc003cpj.1_Missense_Mutation_p.Y16C|CCR3_uc003cpk.1_Missense_Mutation_p.Y37C|CCR3_uc010hjb.1_Missense_Mutation_p.Y34C|CCR3_uc003cpl.1_Missense_Mutation_p.Y49C	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	16	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		ACCACATCCTACTATGATGAC	0.478													0	0	0	0.002299	0	19	21										G	46306696	A	G	46306696	3	3	94	1	0	0	0	0	1	0	0	0	2942	391	14	5	116	5	CCR3	3	46306696	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08		46306696	151715734	55	28082										
CCR5	1234	broad.mit.edu	37	chr3	46414985	46414985	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agaatttccagacattaaagAtagtcatcttggggctggtc	10	7	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:46414985A>G	uc003cpo.3	+	3	714	c.592A>G	c.(592-594)ATA>GTA	p.I198V	CCR5_uc010hjd.2_Missense_Mutation_p.I198V	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	198	Extracellular (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GACATTAAAGATAGTCATCTT	0.438													0	0	0	0.00361	0	110	127										G	46414985	A	G	46414985	3	3	94	1	0	0	0	0	1	0	0	0	2944	333	12	5	594	5	CCR5	3	46414985	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	108289	46414985	151607445	56	28083										
FLNB	2317	broad.mit.edu	37	chr3	58120443	58120443	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgcctgccagtctacctgtgGactttgcaattgatgcccga	10	12	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:58120443G>T	uc003djj.2	+	27	4780	c.4615G>T	c.(4615-4617)GAC>TAC	p.D1539Y	FLNB_uc010hne.2_Missense_Mutation_p.D1570Y|FLNB_uc003djk.2_Missense_Mutation_p.D1539Y|FLNB_uc010hnf.2_Missense_Mutation_p.D1539Y|FLNB_uc003djl.2_Missense_Mutation_p.D1370Y|FLNB_uc003djm.2_Missense_Mutation_p.D1370Y	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1539	Filamin 14.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TCTACCTGTGGACTTTGCAAT	0.507													1	0	4.17463e-26	0.00361	7.98956e-26	52	70										T	58120443	G	T	58120443	3	4	94	1	0	0	0	0	1	0	0	0	5934	1174	41	3	4818	3	FLNB	3	58120443	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	11705458	58120443	139901987	57	28084										
IQCB1	9657	broad.mit.edu	37	chr3	121507259	121507259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgatttctcttccatttcccGatagtgtttctccacctgac	5	13	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:121507259G>A	uc010hre.1	-	12	1365	c.1150C>T	c.(1150-1152)CGG>TGG	p.R384W	IQCB1_uc003eek.2_Missense_Mutation_p.R251W|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	384					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TCCATTTCCCGATAGTGTTTC	0.388													0	0	0	0.00361	0	50	211										A	121507259	G	A	121507259	3	1	94	1	0	0	0	0	1	0	0	0	7803	1057	37	1	662	1	IQCB1	3	121507259	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	63386816	121507259	76515171	58	28085										
SEMA5B	54437	broad.mit.edu	37	chr3	122646791	122646791	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gctgtggagttgtggcgtggGtcataggggcagcgggccac	20	8	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:122646791G>C	uc003efz.1	-	8	1000	c.696C>G	c.(694-696)GAC>GAG	p.D232E	SEMA5B_uc011bju.1_Missense_Mutation_p.D174E|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.D232E|SEMA5B_uc010hro.1_Missense_Mutation_p.D174E|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	232	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGTGGCGTGGGTCATAGGGGC	0.612													0	0	0	0.001855	0	13	87										C	122646791	G	C	122646791	3	2	94	1	0	0	0	0	1	0	0	0	14038	1252	44	4	2823	4	SEMA5B	3	122646791	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1139532	122646791	75375639	59	28086										
DNAJC13	23317	broad.mit.edu	37	chr3	132185188	132185188	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaagctcagatctcgtacctGagaaggatgctgatcggatg	12	8	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:132185188G>C	uc003eor.2	+	19	2079	c.2014G>C	c.(2014-2016)GAG>CAG	p.E672Q	DNAJC13_uc010htq.1_Missense_Mutation_p.E672Q	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	672							heat shock protein binding			ovary(1)|breast(1)	2						TCTCGTACCTGAGAAGGATGC	0.393													0	0	0	0.007413	0	17	63										C	132185188	G	C	132185188	3	2	94	1	0	0	0	0	1	0	0	0	4632	1291	45	1	2084	1	DNAJC13	3	132185188	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9538397	132185188	65837242	60	28087										
XRN1	54464	broad.mit.edu	37	chr3	142151723	142151723	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	catatccaggtacaagttgtCaaattcaggaatctgaaaaa	7	7	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:142151723C>G	uc003eus.2	-	2	155	c.88G>C	c.(88-90)GAC>CAC	p.D30H	XRN1_uc003eut.2_Missense_Mutation_p.D30H|XRN1_uc003euu.2_Missense_Mutation_p.D30H|XRN1_uc003euw.2_Missense_Mutation_p.D30H|XRN1_uc011bnh.1_5'UTR	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	30					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TACAAGTTGTCAAATTCAGGA	0.308													0	0	0	0.006214	0	10	45										G	142151723	C	G	142151723	3	3	94	1	0	0	0	0	1	0	0	0	17456	826	29	1	5196	1	XRN1	3	142151723	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	9966535	142151723	55870707	61	28088										
CCNL1	57018	broad.mit.edu	37	chr3	156877198	156877198	+	Frame_Shift_Del	DEL	A	A	-													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctccgctgtgcttacctcgAaactgtgtttgacgaaagat							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:156877198delA	uc003fbf.2	-	2	973	c.374delT	c.(373-375)TTCfs	p.F125fs	CCNL1_uc003fbd.1_Frame_Shift_Del_p.F125fs|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA|CCNL1_uc003fbi.1_5'UTR	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	125	Cyclin-like 1.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			GCTTACCTCGAAACTGTGTTT	0.517																		17	50	---	---								-	156877198	A	-	156877198	7	5	94	1	0	1	0	1	0	0	0	0	2931	246	9	0	1246	0	CCNL1	3	156877198	Frame_Shift_Del	DEL	A	TCGA-G2-A2EJ-01A-11D-A17V-08	14725475	156877198	41145232	62	28089										
GFM1	85476	broad.mit.edu	37	chr3	158363446	158363446	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaaggcctgccgatggtcttCatcaggggtgattcctaatg	13	9	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:158363446C>T	uc003fce.2	+	2	217	c.110C>T	c.(109-111)TCA>TTA	p.S37L	GFM1_uc003fcd.2_Missense_Mutation_p.S37L|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_5'Flank	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	37					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CGATGGTCTTCATCAGGGGTG	0.368													0	0	0	0.002299	0	22	65										T	158363446	C	T	158363446	3	4	94	1	0	0	0	0	1	0	0	0	6341	838	29	1	116	1	GFM1	3	158363446	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1486248	158363446	39658984	63	28090										
SLC7A14	57709	broad.mit.edu	37	chr3	170216488	170216488	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtggggcaagaactggccctCcgcccagtatttcccattga	11	13	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:170216488C>T	uc003fgz.2	-	4	1043	c.727G>A	c.(727-729)GAG>AAG	p.E243K	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	243						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AACTGGCCCTCCGCCCAGTAT	0.517													0	0	0	0.003163	0	15	44										T	170216488	C	T	170216488	3	4	94	1	0	0	0	0	1	0	0	0	14696	864	30	1	1608	1	SLC7A14	3	170216488	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	11853042	170216488	27805942	64	28091										
PIK3CA	5290	broad.mit.edu	37	chr3	178928074	178928074	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctttggccagtacctcatgGattagaagatttgctgaacc	9	9	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:178928074G>T	uc003fjk.2	+	8	1509	c.1352G>T	c.(1351-1353)GGA>GTA	p.G451V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	451	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G451_L456>V(1)|p.P449_L455del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTACCTCATGGATTAGAAGAT	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			1	0	9.65021e-13	0.002096	1.78626e-12	30	102										T	178928074	G	T	178928074	3	4	94	1	0	0	0	0	1	0	0	0	11913	1174	41	3	1378	3	PIK3CA	3	178928074	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8711586	178928074	19094356	65	28092										
ECE2	9718	broad.mit.edu	37	chr3	184001650	184001650	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cccacctccacgagggagcaGatgcagcaggtgctggagtt	14	12	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:184001650G>C	uc003fni.3	+	8	1286	c.1248G>C	c.(1246-1248)CAG>CAC	p.Q416H	ECE2_uc011brh.1_Missense_Mutation_p.Q269H|ECE2_uc003fnl.3_Missense_Mutation_p.Q344H|ECE2_uc003fnm.3_Missense_Mutation_p.Q298H|ECE2_uc003fnk.3_Missense_Mutation_p.Q269H|ECE2_uc011bri.1_Missense_Mutation_p.Q331H|ECE2_uc010hxv.2_Missense_Mutation_p.Q60H	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	416	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CGAGGGAGCAGATGCAGCAGG	0.597													0	0	0	0.001984	0	7	27										C	184001650	G	C	184001650	3	2	94	1	0	0	0	0	1	0	0	0	4890	933	33	1	1842	1	ECE2	3	184001650	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5073576	184001650	14020780	66	28093										
C3orf59	151963	broad.mit.edu	37	chr3	192516720	192516720	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gatgatggctttgcaggcctGataggcctgcatgaggctgc	15	9	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557													0	0	0	0.000978	0	11	44										C	192516720	G	C	192516720	3	2	94	1	0	0	0	0	1	0	0	0	2237	1299	45	1	548	1	C3orf59	3	192516720	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8515070	192516720	5505710	67	28094										
ZDHHC19	131540	broad.mit.edu	37	chr3	195925257	195925257	+	Frame_Shift_Del	DEL	A	A	-													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agggggacattggagggtgcAgattcggcatggatgtccag							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:195925257delA	uc003fwc.2	-	7	953	c.839delT	c.(838-840)CTGfs	p.L280fs	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_Intron	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	280						integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		TGGAGGGTGCAGATTCGGCAT	0.652																		12	58	---	---								-	195925257	A	-	195925257	7	5	94	1	0	1	0	1	0	0	0	0	17606	188	7	0	94	0	ZDHHC19	3	195925257	Frame_Shift_Del	DEL	A	TCGA-G2-A2EJ-01A-11D-A17V-08	3408537	195925257	2097173	68	28095										
ATP10D	57205	broad.mit.edu	37	chr4	47538490	47538491	+	Frame_Shift_Ins	INS	-	-	T													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcaggtatgaaaagatgcaINSttttttcaatgttcccgagc							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:47538490_47538491insT	uc003gxk.1	+	8	1216_1217	c.1052_1053insT	c.(1051-1053)CATfs	p.H351fs	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Frame_Shift_Ins_p.H351fs	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	351	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GAAAAGATGCATTTTTTCAATG	0.342																		112	80	---	---								T	47538491	-	T	47538490	7	5	94	1	0	1	1	0	0	0	0	0	1118	217	8	0	1078	0	ATP10D	4	47538490	Frame_Shift_Ins	INS	-	TCGA-G2-A2EJ-01A-11D-A17V-08		47538490	143615786	69	28096										
SMR3B	10879	broad.mit.edu	37	chr4	71255498	71255498	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tccaccctatggtccagggaGaatcccacctcctcctcccg	7	19	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:71255498G>C	uc011cas.1	+	3	254	c.173G>C	c.(172-174)AGA>ACA	p.R58T	SMR3B_uc003hfh.2_Missense_Mutation_p.R58T	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	58	Pro-rich.					extracellular space		p.R58K(1)		skin(1)	1		all_hematologic(202;0.196)				GGTCCAGGGAGAATCCCACCT	0.602													0	0	0	0.003755	0	33	47										C	71255498	G	C	71255498	3	2	94	1	0	0	0	0	1	0	0	0	14812	942	33	1	179	1	SMR3B	4	71255498	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	23717008	71255498	119898778	70	28097										
PDLIM5	10611	broad.mit.edu	37	chr4	95561504	95561504	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccaactcagctttgggacaaAcccagccaagtgaccaggac	9	14	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:95561504A>C	uc003hti.2	+	9	1337	c.1186A>C	c.(1186-1188)ACC>CCC	p.T396P	PDLIM5_uc011cdx.1_Missense_Mutation_p.T293P|PDLIM5_uc003hth.2_Missense_Mutation_p.T287P|PDLIM5_uc003htj.2_Missense_Mutation_p.T71P|PDLIM5_uc003htk.2_Missense_Mutation_p.T425P|PDLIM5_uc011cdy.1_Missense_Mutation_p.T274P|PDLIM5_uc003htl.2_Missense_Mutation_p.T71P	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	396					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		TTTGGGACAAACCCAGCCAAG	0.493													0	0	0	0.002445	0	33	42										C	95561504	A	C	95561504	3	2	94	1	0	0	0	0	1	0	0	0	11683	43	2	5	1376	5	PDLIM5	4	95561504	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	24306006	95561504	95592772	71	28098										
CENPE	1062	broad.mit.edu	37	chr4	104082504	104082504	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atacttaccattttctccttCagctccagattttcacttct	2	13	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:104082504C>G	uc003hxb.1	-	19	2043	c.1953G>C	c.(1951-1953)CTG>CTC	p.L651L	CENPE_uc003hxc.1_Silent_p.L626L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	651	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTTCTCCTTCAGCTCCAGAT	0.333													0	0	0	0.000248	0	4	43										G	104082504	C	G	104082504	2	3	94	1	0	0	0	0	0	0	0	1	3230	813	29	1		1	CENPE	4	104082504	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	8521000	104082504	87071772	72	28099										
TET2	54790	broad.mit.edu	37	chr4	106157172	106157172	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caaagagcagattcccaaacTgaaaaacttatgtccccagt	6	11	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:106157172T>G	uc003hxk.2	+	3	2459	c.2073T>G	c.(2071-2073)ACT>ACG	p.T691T	TET2_uc011cez.1_Silent_p.T712T|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.T691T|TET2_uc003hxi.1_Silent_p.T691T	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	691	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ATTCCCAAACTGAAAAACTTA	0.418			Mis N|F		MDS								0	0	0	0.00245	0	13	69										G	106157172	T	G	106157172	2	3	94	1	0	0	0	0	0	0	0	1	15767	1567	55	5		5	TET2	4	106157172	Silent	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	2074668	106157172	84997104	73	28100										
CAMK2D	817	broad.mit.edu	37	chr4	114434999	114434999	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttcttacctttagttttcttCtagcattaaatttcttcaag	3	8	5	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:114434999C>G	uc003ibi.2	-	11	1749	c.890G>C	c.(889-891)AGA>ACA	p.R297T	CAMK2D_uc003ibj.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibk.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibo.3_Missense_Mutation_p.R297T|CAMK2D_uc003ibm.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibn.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibl.2_Missense_Mutation_p.R297T	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	297	Calmodulin-binding (By similarity).				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TAGTTTTCTTCTAGCATTAAA	0.353													0	0	0	0.000248	0	4	33										G	114434999	C	G	114434999	3	3	94	1	0	0	0	0	1	0	0	0	2601	913	32	1	736	1	CAMK2D	4	114434999	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	8277827	114434999	76719277	74	28101										
INPP4B	8821	broad.mit.edu	37	chr4	142949964	142949964	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcttttccataagtcccctCtggaggtctgtagtacttgg	10	10	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:142949964C>G	uc003iix.3	-	27	3341	c.2746G>C	c.(2746-2748)GAG>CAG	p.E916Q	INPP4B_uc003iiw.3_Missense_Mutation_p.E916Q|INPP4B_uc011chm.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	916					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TAAGTCCCCTCTGGAGGTCTG	0.393													0	0	0	0.002522	0	40	17										G	142949964	C	G	142949964	3	3	94	1	0	0	0	0	1	0	0	0	7753	922	32	1	32	1	INPP4B	4	142949964	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	28514965	142949964	48204312	75	28102										
DCLK2	166614	broad.mit.edu	37	chr4	151153948	151153948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atctccatggcctcagcatcGtgcacagagacatcaaacca	7	14	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:151153948G>A	uc003ilm.3	+	10	1634	c.1534G>A	c.(1534-1536)GTG>ATG	p.V512M	DCLK2_uc003iln.3_Missense_Mutation_p.V511M|DCLK2_uc003ilo.3_Missense_Mutation_p.V529M|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	512	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					CCTCAGCATCGTGCACAGAGA	0.458													0	0	0	0.00361	0	93	67										A	151153948	G	A	151153948	3	1	94	1	0	0	0	0	1	0	0	0	4292	1145	40	2	1572	2	DCLK2	4	151153948	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8203984	151153948	40000328	76	28103										
DCHS2	54798	broad.mit.edu	37	chr4	155226351	155226351	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taattcaaatgaagcacctgGcatgatttcaaactgaagct	7	8	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:155226351G>A	uc003inw.2	-	16	3928	c.3928C>T	c.(3928-3930)CCA>TCA	p.P1310S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1310	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAAGCACCTGGCATGATTTCA	0.343													0	0	0	0.006122	0	17	15										A	155226351	G	A	155226351	3	1	94	1	0	0	0	0	1	0	0	0	4288	1203	42	2	4862	2	DCHS2	4	155226351	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4072403	155226351	35927925	77	28104										
C4orf27	54969	broad.mit.edu	37	chr4	170674911	170674911	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agaaagcttataatgattttCtacttcttttcgaaggtcac	6	7	3	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:170674911C>T	uc003isl.3	-	2	189	c.124G>A	c.(124-126)GAA>AAA	p.E42K		NM_017867	NP_060337	Q9NWY4	CD027_HUMAN	hypothetical protein LOC54969	42						nucleus				ovary(1)|pancreas(1)	2		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)		TAATGATTTTCTACTTCTTTT	0.368													0	0	0	0.008871	0	21	12										T	170674911	C	T	170674911	3	4	94	1	0	0	0	0	1	0	0	0	2258	922	32	1	944	1	C4orf27	4	170674911	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	15448560	170674911	20479365	78	28105										
FAT1	2195	broad.mit.edu	37	chr4	187525001	187525001	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcttcccaatgacgccacctGagtattcttctccagaagag	7	13	3	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:187525001G>C	uc003izf.2	-	19	10867	c.10679C>G	c.(10678-10680)TCA>TGA	p.S3560*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3560	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GACGCCACCTGAGTATTCTTC	0.473										HNSCC(5;0.00058)			0	0	0	0.008361	0	29	19										C	187525001	G	C	187525001	4	2	94	1	0	0	0	0	0	1	0	0	5689	1294	45	1	3123	1	FAT1	4	187525001	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	16850090	187525001	3629275	79	28106										
ADAMTS16	170690	broad.mit.edu	37	chr5	5182156	5182156	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctttccttttattttttccaGtcaggcatgatacgaacaga	6	9	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:5182156G>T	uc003jdl.2	+	4	640	c.502_splice	c.e4-1	p.S168_splice	ADAMTS16_uc003jdk.1_Splice_Site_p.S168_splice|ADAMTS16_uc003jdj.1_Splice_Site_p.S168_splice	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATTTTTTCCAGTCAGGCATGA	0.448													1	0	1.01871e-10	0.008871	1.87147e-10	19	69										T	5182156	G	T	5182156	5	4	94	1	0	0	0	0	0	0	1	0	261	1043	36	4	515	4	ADAMTS16	5	5182156	Splice_Site	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		5182156	175733104	80	28107										
DNAH5	1767	broad.mit.edu	37	chr5	13916475	13916475	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	acctttacaaacagagatgtGatcttctcagaggtattata	7	7	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:13916475G>C	uc003jfd.2	-	9	1221	c.1179C>G	c.(1177-1179)ATC>ATG	p.I393M	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	393	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACAGAGATGTGATCTTCTCAG	0.303									Kartagener_syndrome				0	0	0	0.00308	0	7	36										C	13916475	G	C	13916475	3	2	94	1	0	0	0	0	1	0	0	0	4604	1280	45	1	12979	1	DNAH5	5	13916475	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8734319	13916475	166998785	81	28108										
ANKH	56172	broad.mit.edu	37	chr5	14746024	14746024	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cggatttccgtcaaccagccGtatggcatgtgacccacagg	11	13	1	1	rs111688928		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:14746024G>A	uc003jfm.3	-	7	1201	c.870C>T	c.(868-870)TAC>TAT	p.Y290Y	ANKH_uc003jfl.3_Silent_p.Y3Y	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	290	Cytoplasmic (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						TCAACCAGCCGTATGGCATGT	0.522													0	0	0	0.008871	0	18	31										A	14746024	G	A	14746024	2	1	94	1	0	0	0	0	0	0	0	1	627	1140	40	2		2	ANKH	5	14746024	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	829549	14746024	166169236	82	28109										
C5orf22	55322	broad.mit.edu	37	chr5	31535946	31535946	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cacatgggctcagcagatcaGagagggcagacaccactttt	11	11	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:31535946G>C	uc003jhj.3	+	3	450	c.323G>C	c.(322-324)AGA>ACA	p.R108T	C5orf22_uc011cnw.1_RNA|C5orf22_uc003jhk.3_5'UTR	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	108										ovary(2)	2						CAGCAGATCAGAGAGGGCAGA	0.383													0	0	0	0.001855	0	13	37										C	31535946	G	C	31535946	3	2	94	1	0	0	0	0	1	0	0	0	2285	942	33	1	333	1	C5orf22	5	31535946	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	16789922	31535946	149379314	83	28110										
UGT3A1	133688	broad.mit.edu	37	chr5	35954391	35954391	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agccacatagtgcccagagtGagccccagcagaaacacaaa	9	13	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:35954391G>A	uc003jjv.1	-	7	1642	c.1485C>T	c.(1483-1485)CTC>CTT	p.L495L	UGT3A1_uc003jjw.1_RNA	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	495	Helical; (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGCCCAGAGTGAGCCCCAGCA	0.587													0	0	0	0.001168	0	5	27										A	35954391	G	A	35954391	2	1	94	1	0	0	0	0	0	0	0	1	16960	1277	45	1		1	UGT3A1	5	35954391	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4418445	35954391	144960869	84	28111										
SLC1A3	6507	broad.mit.edu	37	chr5	36671303	36671303	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaaggcaaaattgtacgagtGacagctgcagatgccttcct	11	9	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:36671303G>A	uc003jkj.3	+	4	968	c.492G>A	c.(490-492)GTG>GTA	p.V164V	SLC1A3_uc011cox.1_Silent_p.V57V|SLC1A3_uc010iuy.2_Silent_p.V164V	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	164	Extracellular (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTGTACGAGTGACAGCTGCAG	0.473													0	0	0	0.006214	0	9	23										A	36671303	G	A	36671303	2	1	94	1	0	0	0	0	0	0	0	1	14433	1277	45	1		1	SLC1A3	5	36671303	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	716912	36671303	144243957	85	28112										
C9	735	broad.mit.edu	37	chr5	39306727	39306727	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cacgtttcttactttttgacTaatgagaacaggagcatcat	7	8	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:39306727T>C	uc003jlv.3	-	9	1497	c.1408A>G	c.(1408-1410)AGT>GGT	p.S470G		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	470	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ACTTTTTGACTAATGAGAACA	0.363													0	0	0	0.007413	0	15	41										C	39306727	T	C	39306727	3	2	94	1	0	0	0	0	1	0	0	0	2443	1522	53	5	283	5	C9	5	39306727	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	2635424	39306727	141608533	86	28113										
SSBP2	23635	broad.mit.edu	37	chr5	80911377	80911377	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agtagagatcccaaaatacaCtaaaaaagtaatcatggtaa	6	6	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:80911377C>G	uc003kho.2	-	4	409	c.198_splice	c.e4-1	p.C66_splice	SSBP2_uc003khn.2_Splice_Site|SSBP2_uc003khp.2_Splice_Site_p.C66_splice|SSBP2_uc011ctp.1_Splice_Site_p.C66_splice|SSBP2_uc011ctq.1_Splice_Site_p.C66_splice|SSBP2_uc011ctr.1_Splice_Site_p.C66_splice	NM_012446	NP_036578	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2						regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	haematopoietic_and_lymphoid_tissue(4)|skin(1)	5		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		CCAAAATACACTAAAAAAGTA	0.328													0	0	0	0.001882	0	23	25										G	80911377	C	G	80911377	5	3	94	1	0	0	0	0	0	0	1	0	15179	579	20	4	944	4	SSBP2	5	80911377	Splice_Site	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	41604650	80911377	100003883	87	28114										
GPR98	84059	broad.mit.edu	37	chr5	90049511	90049511	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtatcaccacagaaggggttGaggactcatacaaaggtgct	12	8	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:90049511G>C	uc003kju.2	+	54	11338	c.11242G>C	c.(11242-11244)GAG>CAG	p.E3748Q	GPR98_uc003kjt.2_Missense_Mutation_p.E1454Q|GPR98_uc003kjv.2_Missense_Mutation_p.E1348Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3748	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAAGGGGTTGAGGACTCATA	0.448													0	0	0	0.001984	0	7	32										C	90049511	G	C	90049511	3	2	94	1	0	0	0	0	1	0	0	0	6721	1291	45	1	11456	1	GPR98	5	90049511	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9138134	90049511	90865749	88	28115										
SLCO4C1	353189	broad.mit.edu	37	chr5	101596009	101596009	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgggaagtttttccagcttGaatttctgctgtacctaaaa	8	8	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:101596009G>C	uc003knm.2	-	6	1323	c.1036C>G	c.(1036-1038)CAA>GAA	p.Q346E		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	346	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TTTCCAGCTTGAATTTCTGCT	0.209													0	0	0	0.00308	0	8	6										C	101596009	G	C	101596009	3	2	94	1	0	0	0	0	1	0	0	0	14730	1299	45	1	1170	1	SLCO4C1	5	101596009	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	11546498	101596009	79319251	89	28116										
FBXL17	64839	broad.mit.edu	37	chr5	107216802	107216802	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctgtgcaatcagggtggctCcttggtctgtgatttcttta	11	8	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:107216802C>T	uc011cvc.1	-	8	2308	c.1901G>A	c.(1900-1902)GGA>GAA	p.G634E	FBXL17_uc003kon.3_Missense_Mutation_p.G236E	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	634											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		CAGGGTGGCTCCTTGGTCTGT	0.453													0	0	0	0.001786	0	30	103										T	107216802	C	T	107216802	3	4	94	1	0	0	0	0	1	0	0	0	5713	855	30	1	212	1	FBXL17	5	107216802	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5620793	107216802	73698458	90	28117										
FER	2241	broad.mit.edu	37	chr5	108516519	108516519	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagtgactttggaatgtctcGtcaagaggatggtggagtgt	15	5	2	2	rs151332661		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:108516519G>A	uc003kop.1	+	18	2504	c.2120G>A	c.(2119-2121)CGT>CAT	p.R707H	FER_uc011cvg.1_Missense_Mutation_p.R532H	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	707	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GGAATGTCTCGTCAAGAGGAT	0.423													0	0	0	0.002299	0	23	62										A	108516519	G	A	108516519	3	1	94	1	0	0	0	0	1	0	0	0	5813	1145	40	2	2182	2	FER	5	108516519	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1299717	108516519	72398741	91	28118										
IRF1	3659	broad.mit.edu	37	chr5	131819667	131819667	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtgcacagggaatggcctgGatggagggcaaccggactgg	19	8	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:131819667G>C	uc003kxa.2	-	10	1188	c.954C>G	c.(952-954)ATC>ATG	p.I318M	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.I318M	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	318					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		GAATGGCCTGGATGGAGGGCA	0.587													0	0	0	0.008291	0	10	25										C	131819667	G	C	131819667	3	2	94	1	0	0	0	0	1	0	0	0	7827	1164	41	1	27	1	IRF1	5	131819667	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	23303148	131819667	49095593	92	28119										
PCDHGA6	56109	broad.mit.edu	37	chr5	140755384	140755384	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tccactggcgtggagctggcGccccgctccgcagagcccgg	15	17	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:140755384G>C	uc003ljy.1	+	1	1734	c.1734G>C	c.(1732-1734)GCG>GCC	p.A578A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.A578A	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	578	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGCTGGCGCCCCGCTCCG	0.657													0	0	0	0.00361	0	46	108										C	140755384	G	C	140755384	2	2	94	1	0	0	0	0	0	0	0	1	11558	1074	38	4		4	PCDHGA6	5	140755384	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8935717	140755384	40159876	93	28120										
PCDHGC5	56097	broad.mit.edu	37	chr5	140890566	140890566	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtgccggcaccatgggattGagcgcccgctacggacccca	14	15	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:140890566G>C	uc003lla.1	+	4	2661	c.2661G>C	c.(2659-2661)TTG>TTC	p.L887F	PCDHGA1_uc003lji.1_Missense_Mutation_p.L874F|PCDHGA2_uc003ljk.1_Missense_Mutation_p.L875F|PCDHGA3_uc003ljm.1_Missense_Mutation_p.L875F|PCDHGA3_uc010jfx.1_Missense_Mutation_p.L635F|PCDHGB1_uc003ljo.1_Missense_Mutation_p.L870F|PCDHGA4_uc003ljq.1_Missense_Mutation_p.L874F|PCDHGB2_uc003ljs.1_Missense_Mutation_p.L874F|PCDHGA5_uc003lju.1_Missense_Mutation_p.L874F|PCDHGB3_uc003ljw.1_Missense_Mutation_p.L872F|PCDHGA6_uc003ljy.1_Missense_Mutation_p.L875F|PCDHGA7_uc003lka.1_Missense_Mutation_p.L875F|PCDHGB4_uc003lkc.1_Missense_Mutation_p.L866F|PCDHGA8_uc003lkd.1_Missense_Mutation_p.L875F|PCDHGB5_uc003lkf.1_Missense_Mutation_p.L866F|PCDHGA9_uc003lkh.1_Missense_Mutation_p.L875F|PCDHGB6_uc003lkj.1_Missense_Mutation_p.L873F|PCDHGA10_uc003lkl.1_Missense_Mutation_p.L879F|PCDHGB7_uc003lkn.1_Missense_Mutation_p.L872F|PCDHGA11_uc003lkp.1_Missense_Mutation_p.L693F|PCDHGA11_uc003lkq.1_Missense_Mutation_p.L878F|PCDHGA12_uc003lkt.1_Missense_Mutation_p.L875F|PCDHGC3_uc003lkv.1_Missense_Mutation_p.L877F|PCDHGC3_uc003lkw.1_Missense_Mutation_p.L77F|PCDHGC4_uc003lky.1_Missense_Mutation_p.L881F	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	887	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGGATTGAGCGCCCGCT	0.612													0	0	0	0.00623	0	37	129										C	140890566	G	C	140890566	3	2	94	1	0	0	0	0	1	0	0	0	11571	1281	45	1	2850	1	PCDHGC5	5	140890566	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	135182	140890566	40024694	94	28121										
AFAP1L1	134265	broad.mit.edu	37	chr5	148709287	148709287	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaggatgcccggaggtacttGgtagaaaaagagaagctgga	16	5	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:148709287G>T	uc003lqh.2	+	16	2000	c.1869G>T	c.(1867-1869)TTG>TTT	p.L623F	AFAP1L1_uc010jgy.2_Missense_Mutation_p.L623F|AFAP1L1_uc003lqi.1_Missense_Mutation_p.L238F	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	623	Potential.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGGTACTTGGTAGAAAAAG	0.498													1	0	7.03913e-09	0.001368	1.27715e-08	10	23										T	148709287	G	T	148709287	3	4	94	1	0	0	0	0	1	0	0	0	354	1339	47	4	1931	4	AFAP1L1	5	148709287	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7818721	148709287	32205973	95	28122										
JARID2	3720	broad.mit.edu	37	chr6	15496706	15496706	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggcaggttgaacccaaagtCatgcactaaggaggtggggg	16	7	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:15496706C>T	uc003nbj.2	+	7	1494	c.1250C>T	c.(1249-1251)TCA>TTA	p.S417L	JARID2_uc011diu.1_Missense_Mutation_p.S281L|JARID2_uc011div.1_Missense_Mutation_p.S245L|JARID2_uc011diw.1_Missense_Mutation_p.S379L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	417					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AACCCAAAGTCATGCACTAAG	0.652													0	0	0	0.00499	0	16	47										T	15496706	C	T	15496706	3	4	94	1	0	0	0	0	1	0	0	0	7945	838	29	1	1276	1	JARID2	6	15496706	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		15496706	155618361	96	28123										
LY6G6F	259215	broad.mit.edu	37	chr6	31685471	31685471	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagcccacagggactgctacCtgggagacctgtgcaacagc	12	14	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:31685471C>G	uc003nwb.1	+	6	1039	c.1039C>G	c.(1039-1041)CTG>GTG	p.L347V	LY6G6D_uc003nwf.1_Missense_Mutation_p.L98V|LY6G6D_uc003nwg.1_Missense_Mutation_p.L77V	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	Error:Variant_position_missing_in_Q5SQ64_after_alignment						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						GGACTGCTACCTGGGAGACCT	0.597													0	0	0	0.005524	0	39	109										G	31685471	C	G	31685471	3	3	94	1	0	0	0	0	1	0	0	0	9096	680	24	4		4	LY6G6F	6	31685471	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	16188765	31685471	139429596	97	28124										
RPS18	6222	broad.mit.edu	37	chr6	33243622	33243622	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgttgaggaaagcagacattGacctcaccaagagggcggga	14	8	1	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:33243622G>A	uc003odp.1	+	3	196	c.151G>A	c.(151-153)GAC>AAC	p.D51N	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	51					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						AGCAGACATTGACCTCACCAA	0.512													0	0	0	0.006999	0	36	82										A	33243622	G	A	33243622	3	1	94	1	0	0	0	0	1	0	0	0	13628	1290	45	1	161	1	RPS18	6	33243622	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1558151	33243622	137871445	98	28125										
FTSJD2	23070	broad.mit.edu	37	chr6	37414099	37414099	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttcagggaaggtgaaggattGggtaaatacagccagggtcg	16	5	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:37414099G>T	uc003ons.2	+	4	571	c.318G>T	c.(316-318)TTG>TTT	p.L106F	FTSJD2_uc010jwu.2_Missense_Mutation_p.L106F	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	106	G-patch.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GTGAAGGATTGGGTAAATACA	0.433													1	0	0.000673444	0.008291	0.00116149	10	161										T	37414099	G	T	37414099	3	4	94	1	0	0	0	0	1	0	0	0	6091	1339	47	4	328	4	FTSJD2	6	37414099	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4170477	37414099	133700968	99	28126										
UBE2J1	51465	broad.mit.edu	37	chr6	90039588	90039588	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctgactctgctgctgggccCggcgctgtcgagggctcatg	15	13	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:90039588C>T	uc010kcb.2	-	9	940	c.767G>A	c.(766-768)CGG>CAG	p.R256Q	UBE2J1_uc003pnc.2_Missense_Mutation_p.R256Q	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	256	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CTGCTGGGCCCGGCGCTGTCG	0.517													0	0	0	0.003163	0	15	40										T	90039588	C	T	90039588	3	4	94	1	0	0	0	0	1	0	0	0	16857	652	23	2	193	2	UBE2J1	6	90039588	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	52625489	90039588	81075479	100	28127										
MDN1	23195	broad.mit.edu	37	chr6	90394614	90394614	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctttaagttctttttctaggGgggaacgaagttccacaatt	9	7	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:90394614G>A	uc003pnn.1	-	71	11926	c.11810C>T	c.(11809-11811)CCC>CTC	p.P3937L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3937					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTTCTAGGGGGGAACGAAG	0.388													0	0	0	0.00245	0	13	30										A	90394614	G	A	90394614	3	1	94	1	0	0	0	0	1	0	0	0	9415	1232	43	2	5108	2	MDN1	6	90394614	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	355026	90394614	80720453	101	28128										
C6orf167	253714	broad.mit.edu	37	chr6	97634396	97634396	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagctgcatccgcaagttgtGagaaaggcactacctgtgac	11	11	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:97634396G>A	uc003ppb.2	-	15	2476	c.2210C>T	c.(2209-2211)TCA>TTA	p.S737L	C6orf167_uc011eaf.1_Missense_Mutation_p.S697L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	737					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CGCAAGTTGTGAGAAAGGCAC	0.403													0	0	0	0.006214	0	9	21										A	97634396	G	A	97634396	3	1	94	1	0	0	0	0	1	0	0	0	2342	1294	45	1	1565	1	C6orf167	6	97634396	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7239782	97634396	73480671	102	28129										
FYN	2534	broad.mit.edu	37	chr6	112035566	112035566	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttacgagctgttcaatatttGaaatttttctcctttgtgaa	6	6	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:112035566G>C	uc003pvj.2	-	4	668	c.328C>G	c.(328-330)CAA>GAA	p.Q110E	FYN_uc003pvi.2_Missense_Mutation_p.Q110E|FYN_uc003pvk.2_Missense_Mutation_p.Q110E|FYN_uc003pvh.2_Missense_Mutation_p.Q110E	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	110	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAATATTTGAAATTTTTCT	0.438													0	0	0	0.004482	0	6	33										C	112035566	G	C	112035566	3	2	94	1	0	0	0	0	1	0	0	0	6126	1299	45	1	1485	1	FYN	6	112035566	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	14401170	112035566	59079501	103	28130										
ROS1	6098	broad.mit.edu	37	chr6	117662723	117662723	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taggtccatttggcttgtgaGattctctccaagatataatg	9	7	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:117662723G>C	uc003pxp.1	-	29	4941	c.4742C>G	c.(4741-4743)TCT>TGT	p.S1581C	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1581	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGCTTGTGAGATTCTCTCCA	0.423			T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.00308	0	8	31										C	117662723	G	C	117662723	3	2	94	1	0	0	0	0	1	0	0	0	13531	942	33	1	2361	1	ROS1	6	117662723	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5627157	117662723	53452344	104	28131										
EYA4	2070	broad.mit.edu	37	chr6	133783839	133783839	+	Frame_Shift_Del	DEL	A	A	-													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cattacagagtggctgcctcAgttacagcccagggttctct							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:133783839delA	uc003qec.3	+	9	1119	c.661delA	c.(661-663)AGTfs	p.S221fs	EYA4_uc011ecq.1_Frame_Shift_Del_p.S167fs|EYA4_uc011ecr.1_Frame_Shift_Del_p.S167fs|EYA4_uc003qed.3_Frame_Shift_Del_p.S221fs|EYA4_uc003qee.3_Frame_Shift_Del_p.S198fs|EYA4_uc011ecs.1_Frame_Shift_Del_p.S221fs|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	221					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGGCTGCCTCAGTTACAGCCC	0.473																		23	37	---	---								-	133783839	A	-	133783839	7	5	94	1	0	1	0	1	0	0	0	0	5331	188	7	0	691	0	EYA4	6	133783839	Frame_Shift_Del	DEL	A	TCGA-G2-A2EJ-01A-11D-A17V-08	16121116	133783839	37331228	105	28132										
GRM1	2911	broad.mit.edu	37	chr6	146708053	146708053	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggaaaggagaagtgagctgcTgctggatttgcacggcctgc	16	8	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:146708053T>A	uc010khw.1	+	7	2100	c.1630T>A	c.(1630-1632)TGC>AGC	p.C544S	GRM1_uc010khv.1_Missense_Mutation_p.C544S|GRM1_uc003qll.2_Missense_Mutation_p.C544S|GRM1_uc011edz.1_Missense_Mutation_p.C544S|GRM1_uc011eea.1_Missense_Mutation_p.C544S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	544	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGTGAGCTGCTGCTGGATTTG	0.408													0	0	0	0.001984	0	6	21										A	146708053	T	A	146708053	3	1	94	1	0	0	0	0	1	0	0	0	6796	1580	55	5	1652	5	GRM1	6	146708053	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	12924214	146708053	24407014	106	28133										
MTHFD1L	25902	broad.mit.edu	37	chr6	151203955	151203955	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagtacatggccttgcccttCagatctctgagaacttgttt	9	10	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:151203955C>T	uc003qob.2	+	5	743	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Nonsense_Mutation_p.Q159*|MTHFD1L_uc003qoc.2_Nonsense_Mutation_p.Q106*|MTHFD1L_uc003qoa.1_Nonsense_Mutation_p.Q159*|MTHFD1L_uc010kil.1_RNA	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	159	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		CCTTGCCCTTCAGATCTCTGA	0.308													0	0	0	0.000978	0	11	36										T	151203955	C	T	151203955	4	4	94	1	0	0	0	0	0	1	0	0	9928	827	29	1	493	1	MTHFD1L	6	151203955	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4495902	151203955	19911112	107	28134										
ZBTB2	57621	broad.mit.edu	37	chr6	151687786	151687786	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggcttgtctcaactgatgatCtgcaatctgaatgccataca	8	10	3	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:151687786C>T	uc003qoh.2	-	3	550	c.415G>A	c.(415-417)GAT>AAT	p.D139N		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		AACTGATGATCTGCAATCTGA	0.547													0	0	0	0.008361	0	32	67										T	151687786	C	T	151687786	3	4	94	1	0	0	0	0	1	0	0	0	17525	913	32	1	1133	1	ZBTB2	6	151687786	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	483831	151687786	19427281	108	28135										
ZDHHC14	79683	broad.mit.edu	37	chr6	158074650	158074650	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tacggggccacgcagtcacaGagtgacatggtaggagtggg	17	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:158074650G>A	uc003qqt.2	+	8	1556	c.1059G>A	c.(1057-1059)CAG>CAA	p.Q353Q	ZDHHC14_uc003qqs.2_Silent_p.Q353Q|ZDHHC14_uc010kjn.2_Silent_p.Q8Q	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	353						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CGCAGTCACAGAGTGACATGG	0.607													0	0	0	0.001368	0	12	30										A	158074650	G	A	158074650	2	1	94	1	0	0	0	0	0	0	0	1	17601	933	33	1		1	ZDHHC14	6	158074650	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	6386864	158074650	13040417	109	28136										
SYTL3	94120	broad.mit.edu	37	chr6	159166530	159166530	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agggaagtttaattagcattGacagcacctgtacagagatg	11	6	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:159166530G>C	uc003qrp.2	+	11	1118	c.874G>C	c.(874-876)GAC>CAC	p.D292H	SYTL3_uc011efp.1_Missense_Mutation_p.D292H|SYTL3_uc003qro.2_Missense_Mutation_p.D224H|SYTL3_uc003qrq.2_Missense_Mutation_p.D224H|SYTL3_uc003qrr.2_Missense_Mutation_p.D292H|SYTL3_uc003qrs.2_Missense_Mutation_p.D224H|SYTL3_uc011efq.1_Missense_Mutation_p.D18H	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	292					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		AATTAGCATTGACAGCACCTG	0.323													0	0	0	0.00308	0	7	21										C	159166530	G	C	159166530	3	2	94	1	0	0	0	0	1	0	0	0	15481	1290	45	1	696	1	SYTL3	6	159166530	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1091880	159166530	11948537	110	28137										
SYTL3	94120	broad.mit.edu	37	chr6	159166673	159166673	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cttgcctatggagaagaaaaGaagaaaaagtgcaatccgta	10	6	0	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:159166673G>C	uc003qrp.2	+	11	1261	c.1017G>C	c.(1015-1017)AAG>AAC	p.K339N	SYTL3_uc011efp.1_Missense_Mutation_p.K339N|SYTL3_uc003qro.2_Missense_Mutation_p.K271N|SYTL3_uc003qrq.2_Missense_Mutation_p.K271N|SYTL3_uc003qrr.2_Missense_Mutation_p.K339N|SYTL3_uc003qrs.2_Missense_Mutation_p.K271N|SYTL3_uc011efq.1_Missense_Mutation_p.K65N	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	339	C2 1.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		GAGAAGAAAAGAAGAAAAAGT	0.244													0	0	0	0.004482	0	7	31										C	159166673	G	C	159166673	3	2	94	1	0	0	0	0	1	0	0	0	15481	933	33	1	839	1	SYTL3	6	159166673	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	143	159166673	11948394	111	28138										
WTAP	9589	broad.mit.edu	37	chr6	160169273	160169273	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagccgagcgttgcccaactGagatcaacaatggtagaccc	10	13	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:160169273G>C	uc003qsl.2	+	6	546	c.324G>C	c.(322-324)CTG>CTC	p.L108L	WTAP_uc010kjx.2_Silent_p.L108L|WTAP_uc003qsk.2_Silent_p.L108L|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Silent_p.L108L	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	108					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TTGCCCAACTGAGATCAACAA	0.418													0	0	0	0.00245	0	12	39										C	160169273	G	C	160169273	2	2	94	1	0	0	0	0	0	0	0	1	17406	1277	45	1		1	WTAP	6	160169273	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1002600	160169273	10945794	112	28139										
MACC1	346389	broad.mit.edu	37	chr7	20199869	20199869	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caagtctgggtcctggcattCttgttatttaaggaaagaca	10	7	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:20199869C>T	uc003sus.3	-	5	425	c.116_splice	c.e5-1	p.E39_splice	MACC1_uc010kug.2_Splice_Site_p.E39_splice	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5						positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TCCTGGCATTCTTGTTATTTA	0.388													0	0	0	0.001368	0	13	29										T	20199869	C	T	20199869	5	4	94	1	0	0	0	0	0	0	1	0	9143	927	32	1	2455	1	MACC1	7	20199869	Splice_Site	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		20199869	138938794	113	28140										
TRA2A	29896	broad.mit.edu	37	chr7	23571441	23571441	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttgttttcctccacatcactCatgtcgacgaggcgctcccc	7	16	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:23571441C>T	uc003swi.2	-	1	217	c.3G>A	c.(1-3)ATG>ATA	p.M1I	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_5'UTR|TRA2A_uc011jzd.1_5'UTR|TRA2A_uc010kuo.1_RNA	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	1					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						CCACATCACTCATGTCGACGA	0.582													0	0	0	0.001882	0	19	40										T	23571441	C	T	23571441	3	4	94	1	0	0	0	0	1	0	0	0	16430	826	29	1	877	1	TRA2A	7	23571441	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3371572	23571441	135567222	114	28141										
NEUROD6	63974	broad.mit.edu	37	chr7	31378699	31378699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttcctcttccctgtcttcctCctcttcttctttctcggttt	3	16	6	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:31378699C>T	uc003tch.2	-	2	537	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	62	Poly-Glu.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						ctgtcttcctcctcttcttct	0.323													0	0	0	0.00361	0	54	83										T	31378699	C	T	31378699	3	4	94	1	0	0	0	0	1	0	0	0	10351	864	30	1	833	1	NEUROD6	7	31378699	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	7807258	31378699	127759964	115	28142										
NEUROD6	63974	broad.mit.edu	37	chr7	31378712	31378712	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcttcctcctcttcttctttCtcggtttcttctccaggggc	6	15	7	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:31378712C>T	uc003tch.2	-	2	524	c.171G>A	c.(169-171)GAG>GAA	p.E57E		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	57	Poly-Glu.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						cttcttctttctcggtttctt	0.323													0	0	0	0.00361	0	58	80										T	31378712	C	T	31378712	2	4	94	1	0	0	0	0	0	0	0	1	10351	912	32	1		1	NEUROD6	7	31378712	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	13	31378712	127759951	116	28143										
AMPH	273	broad.mit.edu	37	chr7	38431490	38431490	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtagccagctccggtgtctcGctggtggggcccggaggagc	18	12	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:38431490G>A	uc003tgu.2	-	19	1806	c.1737C>T	c.(1735-1737)AGC>AGT	p.S579S	AMPH_uc003tgv.2_Silent_p.S537S|AMPH_uc003tgt.2_Silent_p.S464S|AMPH_uc003tgw.1_Silent_p.S602S|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	579					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CCGGTGTCTCGCTGGTGGGGC	0.612													0	0	0	0.001855	0	13	25										A	38431490	G	A	38431490	2	1	94	1	0	0	0	0	0	0	0	1	588	1078	38	2		2	AMPH	7	38431490	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7052778	38431490	120707173	117	28144										
ZNF479	90827	broad.mit.edu	37	chr7	57193755	57193755	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggctaccatctcatttctctTtatattctgggactctttat	5	10	4	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:57193755T>A	uc010kzo.2	-	4	503	c.232A>T	c.(232-234)AAG>TAG	p.K78*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCATTTCTCTTTATATTCTGG	0.408													0	0	0	0.003755	0	29	90										A	57193755	T	A	57193755	4	1	94	1	0	0	0	0	0	1	0	0	17930	1850	64	5	1350	5	ZNF479	7	57193755	Nonsense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	18762265	57193755	101944908	118	28145										
HIP1	3092	broad.mit.edu	37	chr7	75190635	75190635	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcagatccaagttatacctCagtcttcatgttttctagct	6	10	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:75190635C>G	uc003uds.1	-	13	1230	c.1189G>C	c.(1189-1191)GAG>CAG	p.E397Q	HIP1_uc011kfz.1_Missense_Mutation_p.E274Q	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	397	Potential.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						AGTTATACCTCAGTCTTCATG	0.378			T	PDGFRB	CMML								0	0	0	0.006999	0	39	125										G	75190635	C	G	75190635	3	3	94	1	0	0	0	0	1	0	0	0	7114	835	29	1	2000	1	HIP1	7	75190635	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	17996880	75190635	83948028	119	28146										
PION	54103	broad.mit.edu	37	chr7	76982908	76982908	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccaattataaattcctgaatGaggtcaaatgaatggcaggc	9	7	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:76982908G>T	uc003ugf.2	-	17	1468	c.1389C>A	c.(1387-1389)CTC>CTA	p.L463L	PION_uc003ugg.1_Silent_p.L248L	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	463					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ATTCCTGAATGAGGTCAAATG	0.373													1	0	6.72482e-11	0.003163	1.23852e-10	15	41										T	76982908	G	T	76982908	2	4	94	1	0	0	0	0	0	0	0	1	11934	1277	45	3		3	PION	7	76982908	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1792273	76982908	82155755	120	28147										
PCLO	27445	broad.mit.edu	37	chr7	82390090	82390090	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atattcatcacatatattttCacatataaatctgaaaataa	1	6	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:82390090C>G	uc003uhx.2	-	24	15442	c.15153G>C	c.(15151-15153)GTG>GTC	p.V5051V		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4974	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CATATATTTTCACATATAAAT	0.284													0	0	0	0.000248	0	4	9										G	82390090	C	G	82390090	2	3	94	1	0	0	0	0	0	0	0	1	11583	813	29	1		1	PCLO	7	82390090	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5407182	82390090	76748573	121	28148										
KIAA1324L	222223	broad.mit.edu	37	chr7	86548627	86548627	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atctccagccacctcccaacCtagaagtaataaaagtcatt	4	13	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:86548627C>T	uc011kha.1	-	11	1585	c.1400_splice	c.e11-1	p.G467_splice	KIAA1324L_uc003uif.1_Splice_Site_p.G227_splice|KIAA1324L_uc011kgz.1_Splice_Site_p.G353_splice|KIAA1324L_uc003uie.2_Splice_Site_p.G300_splice	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1							integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					ACCTCCCAACCTAGAAGTAAT	0.333													0	0	0	0.000978	0	11	15										T	86548627	C	T	86548627	5	4	94	1	0	0	0	0	0	0	1	0	8224	695	24	2	1738	2	KIAA1324L	7	86548627	Splice_Site	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4158537	86548627	72590036	122	28149										
C7orf63	79846	broad.mit.edu	37	chr7	89887468	89887468	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaactggtacagtgttatcaGaatggacttgtatcctttac	8	7	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:89887468G>A	uc010lep.2	+	3	488	c.237G>A	c.(235-237)CAG>CAA	p.Q79Q	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Silent_p.Q79Q|C7orf63_uc010leo.2_Silent_p.Q79Q	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	79							binding			ovary(1)	1						AGTGTTATCAGAATGGACTTG	0.244													0	0	0	0.008291	0	11	25										A	89887468	G	A	89887468	2	1	94	1	0	0	0	0	0	0	0	1	2409	933	33	1		1	C7orf63	7	89887468	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3338841	89887468	69251195	123	28150										
CASD1	64921	broad.mit.edu	37	chr7	94175012	94175012	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ataatccaaaaaaaagcaaaCggtaaatatactttcttact	3	7	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:94175012C>T	uc003uni.3	+	12	1859	c.1632C>T	c.(1630-1632)AAC>AAT	p.N544N	CASD1_uc003unj.3_Silent_p.N544N	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	544						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAAAGCAAACGGTAAATATA	0.284													0	0	0	0.006214	0	10	16										T	94175012	C	T	94175012	2	4	94	1	0	0	0	0	0	0	0	1	2664	550	19	2		2	CASD1	7	94175012	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4287544	94175012	64963651	124	28151										
LMTK2	22853	broad.mit.edu	37	chr7	97821646	97821646	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcttaccaggggacttacaCgtgaccagtggccccgagag	13	12	0	2	rs141759251		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:97821646C>T	uc003upd.1	+	11	2162	c.1869C>T	c.(1867-1869)CAC>CAT	p.H623H		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	623					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GGGACTTACACGTGACCAGTG	0.468													0	0	0	0.00499	0	17	48										T	97821646	C	T	97821646	2	4	94	1	0	0	0	0	0	0	0	1	8859	535	19	2		2	LMTK2	7	97821646	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3646634	97821646	61317017	125	28152										
ZNF655	79027	broad.mit.edu	37	chr7	99158255	99158255	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agtctttggagacccagtctGagtgtctgtccccagagcct	11	12	3	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:99158255G>C	uc003urh.2	+	2	466	c.73G>C	c.(73-75)GAG>CAG	p.E25Q	FAM200A_uc003urb.2_5'Flank|ZNF655_uc003urf.2_RNA|ZNF655_uc003urc.2_Missense_Mutation_p.E25Q|ZNF655_uc010lfz.2_Missense_Mutation_p.E25Q|ZNF655_uc003ure.2_RNA|ZNF655_uc010lga.2_Missense_Mutation_p.E25Q|ZNF655_uc010lgb.2_Missense_Mutation_p.E25Q|ZNF655_uc003uri.2_Missense_Mutation_p.E25Q|ZNF655_uc010lgc.2_Missense_Mutation_p.E25Q|ZNF655_uc003urj.2_Missense_Mutation_p.E25Q	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	25					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GACCCAGTCTGAGTGTCTGTC	0.562													0	0	0	0.00333	0	22	49										C	99158255	G	C	99158255	3	2	94	1	0	0	0	0	1	0	0	0	18065	1291	45	1	75	1	ZNF655	7	99158255	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1336609	99158255	59980408	126	28153										
CTTNBP2	83992	broad.mit.edu	37	chr7	117431626	117431626	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttttggagggataggaggagGatttcctctgtcaactcgtg	14	6	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:117431626G>A	uc003vjf.2	-	4	1716	c.1624C>T	c.(1624-1626)CCT>TCT	p.P542S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	542	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ATAGGAGGAGGATTTCCTCTG	0.547													0	0	0	0.005524	0	38	104										A	117431626	G	A	117431626	3	1	94	1	0	0	0	0	1	0	0	0	4045	1174	41	1	3447	1	CTTNBP2	7	117431626	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	18273371	117431626	41707037	127	28154										
CTTNBP2	83992	broad.mit.edu	37	chr7	117450981	117450981	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tagtctctctggagtgccagGaacgggtcatttagattaaa	11	7	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:117450981G>C	uc003vjf.2	-	3	344	c.252C>G	c.(250-252)TTC>TTG	p.F84L		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	84										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGAGTGCCAGGAACGGGTCAT	0.458													0	0	0	0.007413	0	19	57										C	117450981	G	C	117450981	3	2	94	1	0	0	0	0	1	0	0	0	4045	1165	41	1	4823	1	CTTNBP2	7	117450981	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	19355	117450981	41687682	128	28155										
FLNC	2318	broad.mit.edu	37	chr7	128489029	128489029	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggggatgccagcaagtgcctCgtcacaggtgggtgcccacc	15	13	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:128489029C>T	uc003vnz.3	+	28	5129	c.4920C>T	c.(4918-4920)CTC>CTT	p.L1640L	FLNC_uc003voa.3_Silent_p.L1640L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1640	Filamin 15.			L -> T (in Ref. 9; CAA49689).	cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GCAAGTGCCTCGTCACAGGTG	0.657													0	0	0	0.002096	0	28	54										T	128489029	C	T	128489029	2	4	94	1	0	0	0	0	0	0	0	1	5935	871	31	1		1	FLNC	7	128489029	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	11038048	128489029	30649634	129	28156										
TNPO3	23534	broad.mit.edu	37	chr7	128614995	128614995	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	attctgctgttctaggagctGaaaggtggggatgcacagtg	15	6	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:128614995G>C	uc003vol.1	-	18	2574	c.2200C>G	c.(2200-2202)CAG>GAG	p.Q734E	TNPO3_uc010llx.1_Missense_Mutation_p.Q145E|TNPO3_uc003vom.1_Missense_Mutation_p.Q668E|TNPO3_uc010lly.1_Missense_Mutation_p.Q768E|TNPO3_uc010llz.1_Missense_Mutation_p.Q670E	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	734					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TCTAGGAGCTGAAAGGTGGGG	0.428													0	0	0	0.002299	0	21	50										C	128614995	G	C	128614995	3	2	94	1	0	0	0	0	1	0	0	0	16334	1299	45	1	591	1	TNPO3	7	128614995	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	125966	128614995	30523668	130	28157										
TSGA14	95681	broad.mit.edu	37	chr7	130038848	130038848	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggcaccaggcaccttggactCtcttccggaggagttagctt	12	12	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:130038848C>G	uc003vpz.2	-	11	1053	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	TSGA14_uc003vpy.2_Missense_Mutation_p.E98Q|TSGA14_uc010lmf.2_Missense_Mutation_p.E133Q|TSGA14_uc003vqa.2_Missense_Mutation_p.E264Q|TSGA14_uc011kpg.1_Missense_Mutation_p.E248Q	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	336					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					ACCTTGGACTCTCTTCCGGAG	0.587													0	0	0	0.00361	0	53	128										G	130038848	C	G	130038848	3	3	94	1	0	0	0	0	1	0	0	0	16617	922	32	1	119	1	TSGA14	7	130038848	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1423853	130038848	29099815	131	28158										
MLL3	58508	broad.mit.edu	37	chr7	151846037	151846037	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttcagcttgactgtcaccttCagctcatctggcttggcctc	8	14	5	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:151846037C>T	uc003wla.2	-	52	13194	c.12975G>A	c.(12973-12975)CTG>CTA	p.L4325L	MLL3_uc003wkz.2_Silent_p.L3443L|MLL3_uc003wkx.2_Silent_p.L483L|MLL3_uc003wky.2_Silent_p.L1889L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4325					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTGTCACCTTCAGCTCATCTG	0.542			N		medulloblastoma								0	0	0	0.000602	0	5	25										T	151846037	C	T	151846037	2	4	94	1	0	0	0	0	0	0	0	1	9622	813	29	1		1	MLL3	7	151846037	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	21807189	151846037	7292626	132	28159										
ST18	9705	broad.mit.edu	37	chr8	53084872	53084872	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcagaggagcagaagggtggCtgagaatcatcaatcttgtc	13	7	4	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:53084872C>T	uc003xqz.2	-	5	705	c.549G>A	c.(547-549)CAG>CAA	p.Q183Q	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.Q148Q|ST18_uc011lds.1_Silent_p.Q88Q|ST18_uc003xra.2_Silent_p.Q183Q|ST18_uc003xrb.2_Silent_p.Q183Q	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	183						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGAAGGGTGGCTGAGAATCAT	0.448													0	0	0	0.007291	0	31	74										T	53084872	C	T	53084872	2	4	94	1	0	0	0	0	0	0	0	1	15211	796	28	2		2	ST18	8	53084872	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		53084872	93279150	133	28160										
ARFGEF1	10565	broad.mit.edu	37	chr8	68112663	68112663	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tatctttagaactttagttaGaaacaaaagcagtaagttag	7	4	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:68112663G>A	uc003xxo.1	-	38	5743	c.5353C>T	c.(5353-5355)CTA>TTA	p.L1785L	ARFGEF1_uc003xxl.1_Silent_p.L1239L|ARFGEF1_uc003xxm.1_Silent_p.L188L|ARFGEF1_uc003xxn.1_Silent_p.L730L|ARFGEF1_uc003xxp.1_Silent_p.L47L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1785					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ACTTTAGTTAGAAACAAAAGC	0.433													0	0	0	0.003163	0	15	47										A	68112663	G	A	68112663	2	1	94	1	0	0	0	0	0	0	0	1	852	933	33	1		1	ARFGEF1	8	68112663	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	15027791	68112663	78251359	134	28161										
PREX2	80243	broad.mit.edu	37	chr8	69030845	69030845	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcatctgcagcagccagtgCagctcgtatttccacagtga	10	12	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:69030845C>T	uc003xxv.1	+	27	3414	c.3387C>T	c.(3385-3387)TGC>TGT	p.C1129C		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1129					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GCAGCCAGTGCAGCTCGTATT	0.448													0	0	0	0.002445	0	31	71										T	69030845	C	T	69030845	2	4	94	1	0	0	0	0	0	0	0	1	12477	718	25	2		2	PREX2	8	69030845	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	918182	69030845	77333177	135	28162										
LRRCC1	85444	broad.mit.edu	37	chr8	86041588	86041588	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cattagaaaaaatggagagaCaaaaaaggcagcagcaggca	11	6	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:86041588C>A	uc003ycw.2	+	10	1754	c.1600C>A	c.(1600-1602)CAA>AAA	p.Q534K	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Missense_Mutation_p.Q235K|LRRCC1_uc003ycx.2_Missense_Mutation_p.Q441K|LRRCC1_uc003ycy.2_Missense_Mutation_p.Q514K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	534	Potential.				cell division|mitosis	centriole|nucleus					0						AATGGAGAGACAAAAAAGGCA	0.328													1	0	3.69857e-22	0.008361	7.00529e-22	28	84										A	86041588	C	A	86041588	3	1	94	1	0	0	0	0	1	0	0	0	9026	479	17	4	1638	4	LRRCC1	8	86041588	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	17010743	86041588	60322434	136	28163										
KCNQ3	3786	broad.mit.edu	37	chr8	133153445	133153445	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaaacgctctttattgtttaAgccaacaggctttggttctt	8	8	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:133153445A>C	uc003ytj.2	-	10	1621	c.1396T>G	c.(1396-1398)TTA>GTA	p.L466V	KCNQ3_uc010mdt.2_Missense_Mutation_p.L466V	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	466					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTATTGTTTAAGCCAACAGGC	0.443													0	0	0	0.002836	0	30	78										C	133153445	A	C	133153445	3	2	94	1	0	0	0	0	1	0	0	0	8084	69	3	5	1246	5	KCNQ3	8	133153445	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	47111857	133153445	13210577	137	28164										
PTP4A3	11156	broad.mit.edu	37	chr8	142437047	142437047	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttccctccgtaggactggccGtttgacgatggggcgccccc	13	15	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:142437047G>A	uc003ywg.1	+	3	541	c.207G>A	c.(205-207)CCG>CCA	p.P69P	PTP4A3_uc003ywh.1_Silent_p.P69P|PTP4A3_uc010met.1_Intron	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	69						early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			AGGACTGGCCGTTTGACGATG	0.672													0	0	0	0.00361	0	61	100										A	142437047	G	A	142437047	2	1	94	1	0	0	0	0	0	0	0	1	12772	1132	40	2		2	PTP4A3	8	142437047	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9283602	142437047	3926975	138	28165										
FAM83H	286077	broad.mit.edu	37	chr8	144808670	144808670	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccgttctcctgcggcactggGaagccaccctcatcctccat	8	18	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:144808670G>A	uc003yzk.2	-	5	3030	c.2961C>T	c.(2959-2961)TTC>TTT	p.F987F	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	987					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCGGCACTGGGAAGCCACCCT	0.697													0	0	0	0.000602	0	4	20										A	144808670	G	A	144808670	2	1	94	1	0	0	0	0	0	0	0	1	5640	1165	41	1		1	FAM83H	8	144808670	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2371623	144808670	1555352	139	28166										
PLEC	5339	broad.mit.edu	37	chr8	144991585	144991585	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccactcggcgcttgcgcacgGaggacttggaggacgtcttc	14	13	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:144991585G>T	uc003zaf.1	-	32	12985	c.12815C>A	c.(12814-12816)TCC>TAC	p.S4272Y	PLEC_uc003zab.1_Missense_Mutation_p.S4135Y|PLEC_uc003zac.1_Missense_Mutation_p.S4139Y|PLEC_uc003zad.2_Missense_Mutation_p.S4135Y|PLEC_uc003zae.1_Missense_Mutation_p.S4103Y|PLEC_uc003zag.1_Missense_Mutation_p.S4113Y|PLEC_uc003zah.2_Missense_Mutation_p.S4121Y|PLEC_uc003zaj.2_Missense_Mutation_p.S4162Y	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4272	Binding to intermediate filaments (By similarity).|Globular 2.|Plectin 27.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTTGCGCACGGAGGACTTGGA	0.617													1	0	1.15088e-07	0.004007	2.06763e-07	16	34										T	144991585	G	T	144991585	3	4	94	1	0	0	0	0	1	0	0	0	12052	1174	41	3	1243	3	PLEC	8	144991585	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	182915	144991585	1372437	140	28167										
PLEC	5339	broad.mit.edu	37	chr8	145002057	145002057	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtggcctcgagctccgggaGggtggccggcacggcctggg	21	12	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:145002057G>C	uc003zaf.1	-	26	3945	c.3775C>G	c.(3775-3777)CTC>GTC	p.L1259V	PLEC_uc003zab.1_Missense_Mutation_p.L1122V|PLEC_uc003zac.1_Missense_Mutation_p.L1126V|PLEC_uc003zad.2_Missense_Mutation_p.L1122V|PLEC_uc003zae.1_Missense_Mutation_p.L1090V|PLEC_uc003zag.1_Missense_Mutation_p.L1100V|PLEC_uc003zah.2_Missense_Mutation_p.L1108V|PLEC_uc003zaj.2_Missense_Mutation_p.L1149V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1259	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCTCCGGGAGGGTGGCCGGC	0.692													0	0	0	0.000602	0	4	5										C	145002057	G	C	145002057	3	2	94	1	0	0	0	0	1	0	0	0	12052	1000	35	4	10307	4	PLEC	8	145002057	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	10472	145002057	1361965	141	28168										
DOCK8	81704	broad.mit.edu	37	chr9	328082	328082	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcaaaggatttctgcgagctCacacgccttcagtggccgca	10	13	4	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:328082C>T	uc003zgf.2	+	9	1067	c.955C>T	c.(955-957)CAC>TAC	p.H319Y	DOCK8_uc011lls.1_Missense_Mutation_p.H319Y|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Missense_Mutation_p.H251Y|DOCK8_uc003zgg.2_Missense_Mutation_p.H251Y|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	319					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TCTGCGAGCTCACACGCCTTC	0.458													0	0	0	0.000978	0	12	71										T	328082	C	T	328082	3	4	94	1	0	0	0	0	1	0	0	0	4693	826	29	1	989	1	DOCK8	9	328082	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		328082	140885349	142	28169										
GLIS3	169792	broad.mit.edu	37	chr9	4117765	4117766	+	Splice_Site	INS	-	-	A													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cccttgcgcttcggaaactcINSaccgtacacttgttgggctt							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:4117765_4117766insA	uc003zhw.1	-	3	1439	c.1245_splice	c.e3+1	p.T415_splice	GLIS3_uc003zhx.1_Splice_Site_p.T570_splice|GLIS3_uc003zhy.1_Intron|GLIS3_uc003zhz.1_Intron	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TTCGGAAACTCACCGTACACTT	0.559																		70	76	---	---								A	4117766	-	A	4117765	8	5	94	1	0	1	1	0	0	0	1	0	6447	841	29	0		0	GLIS3	9	4117765	Splice_Site	INS	-	TCGA-G2-A2EJ-01A-11D-A17V-08	3789683	4117765	137095666	143	28170										
RRAGA	10670	broad.mit.edu	37	chr9	19050318	19050318	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tttcccactaccagtgcaaaGagcagcgcgacgtccaccgg	10	15	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:19050318G>C	uc003znj.2	+	1	947	c.661G>C	c.(661-663)GAG>CAG	p.E221Q		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	221					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						CCAGTGCAAAGAGCAGCGCGA	0.478													0	0	0	0.006999	0	36	117										C	19050318	G	C	19050318	3	2	94	1	0	0	0	0	1	0	0	0	13672	943	33	1	663	1	RRAGA	9	19050318	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	14932553	19050318	122163113	144	28171										
RUSC2	9853	broad.mit.edu	37	chr9	35561306	35561306	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgcagccgtggccccgactCtggcctggtgcccctggcct	13	18	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:35561306C>T	uc003zww.2	+	12	4733	c.4478C>T	c.(4477-4479)TCT>TTT	p.S1493F	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.S1493F	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1493	SH3.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGCCCCGACTCTGGCCTGGTG	0.647													0	0	0	0.007291	0	25	87										T	35561306	C	T	35561306	3	4	94	1	0	0	0	0	1	0	0	0	13751	913	32	1	4520	1	RUSC2	9	35561306	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	16510988	35561306	105652125	145	28172										
RECK	8434	broad.mit.edu	37	chr9	36110040	36110040	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctacccgcctttgcctcagtGagcacagttcagaagatgac	9	13	2	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:36110040G>A	uc003zyv.2	+	15	1938	c.1852G>A	c.(1852-1854)GAG>AAG	p.E618K	RECK_uc003zyw.2_Missense_Mutation_p.E490K|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	618						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TTGCCTCAGTGAGCACAGTTC	0.478													0	0	0	0.002096	0	34	122										A	36110040	G	A	36110040	3	1	94	1	0	0	0	0	1	0	0	0	13200	1291	45	1	1910	1	RECK	9	36110040	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	548734	36110040	105103391	146	28173										
CEP78	84131	broad.mit.edu	37	chr9	80881596	80881596	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtccagaaatagcagatcttCttcagagaaaaagaccaaaa	7	8	3	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:80881596C>G	uc004akx.2	+	15	2312	c.2036C>G	c.(2035-2037)TCT>TGT	p.S679C	CEP78_uc004aky.3_Missense_Mutation_p.S696C|CEP78_uc010mpp.2_Missense_Mutation_p.S680C|CEP78_uc004akz.1_Missense_Mutation_p.S167C	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	679					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						AGCAGATCTTCTTCAGAGAAA	0.418													0	0	0	0.001984	0	5	19										G	80881596	C	G	80881596	3	3	94	1	0	0	0	0	1	0	0	0	3262	913	32	1	2149	1	CEP78	9	80881596	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	44771556	80881596	60331835	147	28174										
TLE4	7091	broad.mit.edu	37	chr9	82335206	82335206	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgcacaaccagaccttggtGaggtaggttagcaggatctg	13	9	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:82335206G>A	uc004ald.2	+	17	2760	c.1911G>A	c.(1909-1911)GTG>GTA	p.V637V	TLE4_uc004alc.2_Silent_p.V612V|TLE4_uc010mpr.2_Silent_p.V491V|TLE4_uc004ale.2_Silent_p.V249V|TLE4_uc011lsq.1_Silent_p.V580V|TLE4_uc010mps.2_Silent_p.V536V|TLE4_uc004alf.2_Silent_p.V551V	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						AGACCTTGGTGAGGTAGGTTA	0.458													0	0	0	0.000978	0	12	40										A	82335206	G	A	82335206	2	1	94	1	0	0	0	0	0	0	0	1	15938	1277	45	1		1	TLE4	9	82335206	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1453610	82335206	58878225	148	28175										
BICD2	23299	broad.mit.edu	37	chr9	95482616	95482616	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcttcagcttctggatctcaGagatgttgagctcactgagt	11	9	4	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:95482616G>C	uc004aso.1	-	4	1085	c.1028C>G	c.(1027-1029)TCT>TGT	p.S343C	BICD2_uc004asp.1_Missense_Mutation_p.S343C	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	343	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						CTGGATCTCAGAGATGTTGAG	0.632													0	0	0	0.007291	0	29	38										C	95482616	G	C	95482616	3	2	94	1	0	0	0	0	1	0	0	0	1429	942	33	1	1565	1	BICD2	9	95482616	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	13147410	95482616	45730815	149	28176										
BICD2	23299	broad.mit.edu	37	chr9	95482948	95482948	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgccgctctgagatctccttGaggcggatggcatcctccag	12	13	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:95482948G>T	uc004aso.1	-	4	753	c.696C>A	c.(694-696)CTC>CTA	p.L232L	BICD2_uc004asp.1_Silent_p.L232L	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	232	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						AGATCTCCTTGAGGCGGATGG	0.587													1	0	1.06522e-23	0.003214	2.02807e-23	44	63										T	95482948	G	T	95482948	2	4	94	1	0	0	0	0	0	0	0	1	1429	1277	45	3		3	BICD2	9	95482948	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	332	95482948	45730483	150	28177										
GABBR2	9568	broad.mit.edu	37	chr9	101125057	101125057	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	acagcctgccagcagatcagGatacacaggtcgatcagcag	11	12	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:101125057G>C	uc004ays.2	-	13	1989	c.1833C>G	c.(1831-1833)ATC>ATG	p.I611M		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	611	Helical; Name=4; (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	AGCAGATCAGGATACACAGGT	0.592													0	0	0	0.00308	0	8	34										C	101125057	G	C	101125057	3	2	94	1	0	0	0	0	1	0	0	0	6156	1164	41	1	1020	1	GABBR2	9	101125057	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5642109	101125057	40088374	151	28178										
TEX10	54881	broad.mit.edu	37	chr9	103092428	103092428	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agagatgatctatgttattgGagagaactgtgcaatgcttg	12	4	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:103092428G>C	uc004bas.2	-	6	1489	c.1274C>G	c.(1273-1275)TCC>TGC	p.S425C	TEX10_uc011lvf.1_Missense_Mutation_p.S264C|TEX10_uc011lvg.1_Missense_Mutation_p.S428C|TEX10_uc011lvh.1_Missense_Mutation_p.S360C	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	425						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TATGTTATTGGAGAGAACTGT	0.373													0	0	0	0.002522	0	38	95										C	103092428	G	C	103092428	3	2	94	1	0	0	0	0	1	0	0	0	15769	1174	41	1	1555	1	TEX10	9	103092428	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1967371	103092428	38121003	152	28179										
OR13C3	138803	broad.mit.edu	37	chr9	107298443	107298443	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagggatatatcagcacaggCcagcttgaggacagctaata	12	8	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:107298443C>A	uc004bcb.1	-	1	652	c.652G>T	c.(652-654)GCC>TCC	p.A218S		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	218	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCAGCACAGGCCAGCTTGAGG	0.383													1	0	2.44723e-14	0.004656	4.56443e-14	26	76										A	107298443	C	A	107298443	3	1	94	1	0	0	0	0	1	0	0	0	10935	739	26	4	395	4	OR13C3	9	107298443	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4206015	107298443	33914988	153	28180										
SNX30	401548	broad.mit.edu	37	chr9	115567234	115567234	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggagacttacatcacctataGgatcaccaccaaagtaggtc	8	11	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:115567234G>C	uc004bgj.3	+	2	483	c.335G>C	c.(334-336)AGG>ACG	p.R112T		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	112	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						ATCACCTATAGGATCACCACC	0.458													0	0	0	0.004878	0	31	84										C	115567234	G	C	115567234	3	2	94	1	0	0	0	0	1	0	0	0	14900	1000	35	4	341	4	SNX30	9	115567234	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8268791	115567234	25646197	154	28181										
SLC46A2	57864	broad.mit.edu	37	chr9	115652749	115652749	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tagaaattggagatggctctCtgctgttggtcctctagagc	12	8	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:115652749C>G	uc004bgk.2	-	1	445	c.213G>C	c.(211-213)CAG>CAC	p.Q71H		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	71	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						AGATGGCTCTCTGCTGTTGGT	0.632													0	0	0	0.00361	0	79	99										G	115652749	C	G	115652749	3	3	94	1	0	0	0	0	1	0	0	0	14645	912	32	1	1230	1	SLC46A2	9	115652749	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	85515	115652749	25560682	155	28182										
AKNA	80709	broad.mit.edu	37	chr9	117122258	117122258	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggggtcctgtggcctgtcctCcacctcactgttgccagagc	12	15	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:117122258C>G	uc004biq.3	-	9	2344	c.2209G>C	c.(2209-2211)GAG>CAG	p.E737Q	AKNA_uc004bin.3_5'UTR|AKNA_uc004bio.3_Missense_Mutation_p.E197Q|AKNA_uc004bip.3_Missense_Mutation_p.E656Q|AKNA_uc004bir.3_Missense_Mutation_p.E737Q|AKNA_uc004bis.3_Missense_Mutation_p.E737Q|AKNA_uc010mve.2_Missense_Mutation_p.E618Q|AKNA_uc004biu.1_Missense_Mutation_p.E478Q|AKNA_uc004biv.1_Missense_Mutation_p.E737Q	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						GGCCTGTCCTCCACCTCACTG	0.622													0	0	0	0.000978	0	12	53										G	117122258	C	G	117122258	3	3	94	1	0	0	0	0	1	0	0	0	463	864	30	1	2162	1	AKNA	9	117122258	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1469509	117122258	24091173	156	28183										
MEGF9	1955	broad.mit.edu	37	chr9	123476225	123476225	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgcgggtctggtcggcgcctGagaggtggtcgaagtgcgtt	19	9	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:123476225G>C	uc004bkj.1	-	1	388	c.388C>G	c.(388-390)CAG>GAG	p.Q130E	MEGF9_uc011lyb.1_Missense_Mutation_p.Q130E|MEGF9_uc004bkk.3_Missense_Mutation_p.Q130E	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	138	Extracellular (Potential).|Pro-rich.					integral to membrane	calcium ion binding				0						GTCGGCGCCTGAGAGGTGGTC	0.721													0	0	0	0.008871	0	18	30										C	123476225	G	C	123476225	3	2	94	1	0	0	0	0	1	0	0	0	9464	1299	45	1	1563	1	MEGF9	9	123476225	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	6353967	123476225	17737206	157	28184										
CRB2	286204	broad.mit.edu	37	chr9	126128232	126128232	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggaggtggacgagtgcgcctCagcgccctgcctgcacgggg	18	13	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:126128232C>T	uc004bnx.1	+	3	547	c.455C>T	c.(454-456)TCA>TTA	p.S152L	CRB2_uc004bnw.1_Missense_Mutation_p.S152L	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	152	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GAGTGCGCCTCAGCGCCCTGC	0.706													0	0	0	0.004007	0	11	22										T	126128232	C	T	126128232	3	4	94	1	0	0	0	0	1	0	0	0	3849	838	29	1	465	1	CRB2	9	126128232	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2652007	126128232	15085199	158	28185										
DNM1	1759	broad.mit.edu	37	chr9	130984548	130984548	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agagccagctactgtccattGagaaggaggtggaggaatac	14	7	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:130984548G>C	uc011mau.1	+	7	1009	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	DNM1_uc010mxr.2_Missense_Mutation_p.E308Q|DNM1_uc011mat.1_Missense_Mutation_p.E308Q	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	308					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						ACTGTCCATTGAGAAGGAGGT	0.582													0	0	0	0.001523	0	19	66										C	130984548	G	C	130984548	3	2	94	1	0	0	0	0	1	0	0	0	4670	1291	45	1	948	1	DNM1	9	130984548	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4856316	130984548	10228883	159	28186										
SLC27A4	10999	broad.mit.edu	37	chr9	131115460	131115460	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tccacataccccaggtggctGagttctacggggccacagag	12	13	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:131115460G>C	uc004but.2	+	8	1428	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	SLC27A4_uc004buu.2_Intron	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	382					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						CCAGGTGGCTGAGTTCTACGG	0.622													0	0	0	0.003163	0	15	42										C	131115460	G	C	131115460	3	2	94	1	0	0	0	0	1	0	0	0	14528	1291	45	1	1170	1	SLC27A4	9	131115460	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	130912	131115460	10097971	160	28187										
ZER1	10444	broad.mit.edu	37	chr9	131504959	131504959	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggagctcgttgacccggcgGtactggaattccagctcctc	12	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:131504959G>A	uc004bwa.1	-	9	1858	c.1425C>T	c.(1423-1425)TAC>TAT	p.Y475Y		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	475					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TGACCCGGCGGTACTGGAATT	0.632													0	0	0	0.001855	0	12	18										A	131504959	G	A	131504959	2	1	94	1	0	0	0	0	0	0	0	1	17622	1256	44	2		2	ZER1	9	131504959	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	389499	131504959	9708472	161	28188										
PFKFB3	5209	broad.mit.edu	37	chr10	6258109	6258109	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caatgtgccttagctgccttGagagatgtcaaaagctacct	9	10	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:6258109G>C	uc001ije.2	+	4	705	c.321G>C	c.(319-321)TTG>TTC	p.L107F	PFKFB3_uc001ijd.2_Missense_Mutation_p.L87F|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Missense_Mutation_p.L121F|PFKFB3_uc001ijf.2_Missense_Mutation_p.L107F	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	107	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						TAGCTGCCTTGAGAGATGTCA	0.592													0	0	0	0.005524	0	35	63										C	6258109	G	C	6258109	3	2	94	1	0	0	0	0	1	0	0	0	11762	1281	45	1	355	1	PFKFB3	10	6258109	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		6258109	129276638	162	28189										
APBB1IP	54518	broad.mit.edu	37	chr10	26800746	26800746	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggatgagcggcagctggcccGagatgttctggacaaccttt	14	10	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:26800746G>C	uc001iss.2	+	7	923	c.602G>C	c.(601-603)CGA>CCA	p.R201P	APBB1IP_uc009xks.1_Missense_Mutation_p.R201P	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	201	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CAGCTGGCCCGAGATGTTCTG	0.473													0	0	0	0.00278	0	22	64										C	26800746	G	C	26800746	3	2	94	1	0	0	0	0	1	0	0	0	760	1058	37	1	620	1	APBB1IP	10	26800746	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	20542637	26800746	108734001	163	28190										
WAC	51322	broad.mit.edu	37	chr10	28906704	28906704	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgaaattcaagcaactttgcGagagcaaaggtaagtctttc	9	7	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:28906704G>A	uc001iuf.2	+	13	1950	c.1865G>A	c.(1864-1866)CGA>CAA	p.R622Q	WAC_uc001iud.2_Missense_Mutation_p.R577Q|WAC_uc001iue.2_Missense_Mutation_p.R312Q|WAC_uc001iug.2_Missense_Mutation_p.R519Q|WAC_uc001iuh.2_Missense_Mutation_p.R573Q	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	622	Potential.				cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						GCAACTTTGCGAGAGCAAAGG	0.299													0	0	0	0.00308	0	6	22										A	28906704	G	A	28906704	3	1	94	1	0	0	0	0	1	0	0	0	17244	1058	37	1	1915	1	WAC	10	28906704	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2105958	28906704	106628043	164	28191										
ANK3	288	broad.mit.edu	37	chr10	61829613	61829613	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggttccactgtaggtgtctCtacatttctctctagattgg	9	9	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:61829613C>G	uc001jky.2	-	37	11218	c.11026G>C	c.(11026-11028)GAG>CAG	p.E3676Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3676					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTAGGTGTCTCTACATTTCTC	0.552													0	0	0	0.00245	0	15	52										G	61829613	C	G	61829613	3	3	94	1	0	0	0	0	1	0	0	0	622	922	32	1	2448	1	ANK3	10	61829613	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	32922909	61829613	73705134	165	28192										
ANK3	288	broad.mit.edu	37	chr10	61959942	61959942	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccagataccgcacaacttcaGcttggccggagcgagctgcc	11	15	1	1	rs138255802		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:61959942G>T	uc001jky.2	-	13	1628	c.1436C>A	c.(1435-1437)GCT>GAT	p.A479D	ANK3_uc010qih.1_Missense_Mutation_p.A462D|ANK3_uc001jkz.3_Missense_Mutation_p.A473D|ANK3_uc001jlb.1_Missense_Mutation_p.A8D|ANK3_uc001jlc.1_Missense_Mutation_p.A140D	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	479	ANK 13.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CACAACTTCAGCTTGGCCGGA	0.463													1	0	8.00594e-06	0.007413	1.42436e-05	16	40										T	61959942	G	T	61959942	3	4	94	1	0	0	0	0	1	0	0	0	622	971	34	4	12154	4	ANK3	10	61959942	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	130329	61959942	73574805	166	28193										
SYNPO2L	79933	broad.mit.edu	37	chr10	75407393	75407393	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaggctcagagcatcttcttCaggaccagattctgcacccc	9	14	5	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:75407393C>T	uc001jut.3	-	4	2169	c.2017G>A	c.(2017-2019)GAA>AAA	p.E673K	SYNPO2L_uc001jus.3_Missense_Mutation_p.E449K	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	673	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					GCATCTTCTTCAGGACCAGAT	0.592													0	0	0	0.00361	0	44	120										T	75407393	C	T	75407393	3	4	94	1	0	0	0	0	1	0	0	0	15455	835	29	1	920	1	SYNPO2L	10	75407393	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	13447451	75407393	60127354	167	28194										
KIAA0913	23053	broad.mit.edu	37	chr10	75555297	75555297	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taaggtcctctttctcgcagGcatgaagacaacagtgagcg	11	10	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:75555297G>A	uc009xrl.2	+	15	2926	c.2894G>A	c.(2893-2895)GGC>GAC	p.G965D	KIAA0913_uc001jve.2_Missense_Mutation_p.G970D|KIAA0913_uc001jvf.2_Missense_Mutation_p.G965D|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.G393D|KIAA0913_uc010qkr.1_Missense_Mutation_p.G388D|KIAA0913_uc001jvj.2_Missense_Mutation_p.G388D	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	965							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					TTTCTCGCAGGCATGAAGACA	0.488													0	0	0	0.00361	0	42	107										A	75555297	G	A	75555297	3	1	94	1	0	0	0	0	1	0	0	0	8200	1217	42	2	2967	2	KIAA0913	10	75555297	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	147904	75555297	59979450	168	28195										
AP3M1	26985	broad.mit.edu	37	chr10	75886013	75886013	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aattccttcaatagttttccCcatattctgctttggtccaa	4	11	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:75886013C>G	uc001jwf.2	-	7	1334	c.904G>C	c.(904-906)GGG>CGG	p.G302R	AP3M1_uc001jwg.2_Missense_Mutation_p.G302R|AP3M1_uc001jwh.2_Missense_Mutation_p.G302R|AP3M1_uc010qla.1_Missense_Mutation_p.G248R	NM_207012	NP_996895	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	302	MHD.				protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding				0	Prostate(51;0.0112)					ATAGTTTTCCCCATATTCTGC	0.403													0	0	0	0.001882	0	21	73										G	75886013	C	G	75886013	3	3	94	1	0	0	0	0	1	0	0	0	747	623	22	4	364	4	AP3M1	10	75886013	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	330716	75886013	59648734	169	28196										
KCNMA1	3778	broad.mit.edu	37	chr10	78649235	78649235	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtgcactgactgggggtgctGaggtgagcatctctcagccg	16	10	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:78649235G>A	uc001jxn.2	-	27	3612	c.3435C>T	c.(3433-3435)CTC>CTT	p.L1145L	KCNMA1_uc001jxj.2_Silent_p.L1091L|KCNMA1_uc001jxk.1_Silent_p.L763L|KCNMA1_uc009xrt.1_Silent_p.L936L|KCNMA1_uc001jxl.1_Silent_p.L770L|KCNMA1_uc001jxo.2_Silent_p.L1128L|KCNMA1_uc001jxm.2_Silent_p.L1087L|KCNMA1_uc001jxq.2_Silent_p.L1117L|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1145	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGGGGGTGCTGAGGTGAGCAT	0.443													0	0	0	0.008871	0	18	54										A	78649235	G	A	78649235	2	1	94	1	0	0	0	0	0	0	0	1	8073	1277	45	1		1	KCNMA1	10	78649235	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2763222	78649235	56885512	170	28197										
CYP26C1	340665	broad.mit.edu	37	chr10	94824180	94824180	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgcatcggcacctggaggggGccatttctgagaagcttcac	13	11	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:94824180G>T	uc010qns.1	+	4	748	c.748G>T	c.(748-750)GCC>TCC	p.A250S	CYP26C1_uc009xud.2_Intron	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	250					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				CCTGGAGGGGGCCATTTCTGA	0.612													1	0	5.4927e-09	0.004482	9.99045e-09	8	25										T	94824180	G	T	94824180	3	4	94	1	0	0	0	0	1	0	0	0	4157	1203	42	4	762	4	CYP26C1	10	94824180	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	16174945	94824180	40710567	171	28198										
HIF1AN	55662	broad.mit.edu	37	chr10	102295784	102295784	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgggaggaggctggagccctCggccccgcctgggatgaatc	17	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:102295784C>T	uc001krj.3	+	1	144	c.69C>T	c.(67-69)CTC>CTT	p.L23L		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	23	Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		CTGGAGCCCTCGGCCCCGCCT	0.537											OREG0020442	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	4										T	102295784	C	T	102295784	2	4	94	1	0	0	0	0	0	0	0	1	7104	871	31	1		1	HIF1AN	10	102295784	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	7471604	102295784	33238963	172	28199										
SORCS3	22986	broad.mit.edu	37	chr10	106970924	106970924	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtatgagagacatggggagaGccagtgtgtcccagctttct	14	8	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:106970924G>T	uc001kyi.1	+	17	2518	c.2291G>T	c.(2290-2292)AGC>ATC	p.S764I	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	764	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity	p.S764N(1)		ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CATGGGGAGAGCCAGTGTGTC	0.443													1	0	2.61681e-11	0.00245	4.83155e-11	12	22										T	106970924	G	T	106970924	3	4	94	1	0	0	0	0	1	0	0	0	14932	971	34	4	2357	4	SORCS3	10	106970924	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4675140	106970924	28563823	173	28200										
NRAP	4892	broad.mit.edu	37	chr10	115349525	115349525	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaggggtccagccaacacctCtggtcaggttcaagtctgat	12	11	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:115349525C>G	uc001laj.2	-	41	5152	c.4988G>C	c.(4987-4989)AGA>ACA	p.R1663T	NRAP_uc009xyb.2_Missense_Mutation_p.R416T|NRAP_uc001lak.2_Missense_Mutation_p.R1628T|NRAP_uc001lal.3_Missense_Mutation_p.R1663T	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1663	Nebulin 44.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GCCAACACCTCTGGTCAGGTT	0.542													0	0	0	0.001786	0	30	58										G	115349525	C	G	115349525	3	3	94	1	0	0	0	0	1	0	0	0	10638	913	32	1	212	1	NRAP	10	115349525	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	8378601	115349525	20185222	174	28201										
DMBT1	1755	broad.mit.edu	37	chr10	124392811	124392811	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccaagtgtgtgtgggacattGaggtgcaaaacaactaccgt	12	8	0	1	rs112645522		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:124392811G>C	uc001lgk.1	+	49	6221	c.6115G>C	c.(6115-6117)GAG>CAG	p.E2039Q	DMBT1_uc001lgl.1_Missense_Mutation_p.E2029Q|DMBT1_uc001lgm.1_Missense_Mutation_p.E1411Q|DMBT1_uc009xzz.1_Missense_Mutation_p.E2038Q|DMBT1_uc010qtx.1_Missense_Mutation_p.E759Q|DMBT1_uc009yab.1_Missense_Mutation_p.E742Q|DMBT1_uc009yac.1_Missense_Mutation_p.E333Q	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2039	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGGGACATTGAGGTGCAAAA	0.512													0	0	0	0.005443	0	25	55										C	124392811	G	C	124392811	3	2	94	1	0	0	0	0	1	0	0	0	4577	1291	45	1	6309	1	DMBT1	10	124392811	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9043286	124392811	11141936	175	28202										
DOCK1	1793	broad.mit.edu	37	chr10	128798508	128798508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttgttcgcgtgggtcgcatgGagctgagggacaacaacacc	14	10	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:128798508G>A	uc001ljt.2	+	10	986	c.922G>A	c.(922-924)GAG>AAG	p.E308K	DOCK1_uc010qun.1_Missense_Mutation_p.E308K	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	308					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GGGTCGCATGGAGCTGAGGGA	0.453													0	0	0	0.000978	0	11	37										A	128798508	G	A	128798508	3	1	94	1	0	0	0	0	1	0	0	0	4684	1175	41	1	960	1	DOCK1	10	128798508	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4405697	128798508	6736239	176	28203										
ZNF511	118472	broad.mit.edu	37	chr10	135125328	135125328	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctgcaccggcaggtgagagGcggatctacagacataggtc	14	11	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:135125328G>T	uc001lml.1	+	5	688	c.663G>T	c.(661-663)AGG>AGT	p.R221S	TUBGCP2_uc001lmg.1_5'Flank|TUBGCP2_uc010qvc.1_5'Flank|TUBGCP2_uc009ybk.1_5'Flank|TUBGCP2_uc010qvd.1_5'Flank|TUBGCP2_uc001lmh.1_RNA|ZNF511_uc001lmj.1_Missense_Mutation_p.R221S|ZNF511_uc001lmk.1_3'UTR|ZNF511_uc001lmm.1_RNA			Q8NB15	ZN511_HUMAN	SubName: Full=cDNA FLJ78327; SubName: Full=Zinc finger protein 511, isoform CRA_d;	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		CAGGTGAGAGGCGGATCTACA	0.602													1	0	0.000132079	0.008871	0.000230509	19	72										T	135125328	G	T	135125328	3	4	94	1	0	0	0	0	1	0	0	0	17952	1194	42	4	681	4	ZNF511	10	135125328	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	6326820	135125328	409419	177	28204										
HRAS	3265	broad.mit.edu	37	chr11	534288	534288	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcgcactcttgcccacaccgCcggcgcccaccaccaccagc	8	23	1	0	rs104894230		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:534288C>T	uc001lpv.2	-	2	223	c.35G>A	c.(34-36)GGC>GAC	p.G12D	HRAS_uc010qvw.1_Missense_Mutation_p.G12D|HRAS_uc010qvx.1_Missense_Mutation_p.G12D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.006214	0	8	30										T	534288	C	T	534288	3	4	94	1	0	0	0	0	1	0	0	0	7348	739	26	2	617	2	HRAS	11	534288	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		534288	134472228	178	28205										
LRDD	55367	broad.mit.edu	37	chr11	802583	802583	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaacagtctgggcatttctgGaatgagggctgccactgtgc	14	9	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:802583G>T	uc001lro.1	-	5	1076	c.934C>A	c.(934-936)CCA>ACA	p.P312T	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.P312T|LRDD_uc001lrl.1_Missense_Mutation_p.P166T|LRDD_uc001lrm.1_5'UTR|LRDD_uc001lrn.1_Missense_Mutation_p.P166T|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	312					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGCATTTCTGGAATGAGGGCT	0.587													1	0	2.56e-06	0.000248	4.56564e-06	4	11										T	802583	G	T	802583	3	4	94	1	0	0	0	0	1	0	0	0	8936	1174	41	3	1846	3	LRDD	11	802583	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	268295	802583	134203933	179	28206										
TRIM21	6737	broad.mit.edu	37	chr11	4411526	4411526	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttcccaacctgagagatgcaTtcctggcagaagctgtggcc	11	12	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:4411526T>A	uc001lyy.1	-	2	227	c.114A>T	c.(112-114)GAA>GAT	p.E38D		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	38	RING-type.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		GAGAGATGCATTCCTGGCAGA	0.587													0	0	0	0.00623	0	37	66										A	4411526	T	A	4411526	3	1	94	1	0	0	0	0	1	0	0	0	16492	1490	52	5	1337	5	TRIM21	11	4411526	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	3608943	4411526	130594990	180	28207										
OR52L1	338751	broad.mit.edu	37	chr11	6008147	6008147	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggagaggaaagagaaaaaaGaaaccaaagtcatgatttct	10	4	2	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:6008147G>C	uc001mcd.2	-	1	69	c.14C>G	c.(13-15)TCT>TGT	p.S5C		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGAAAAAAGAAACCAAAGT	0.423													0	0	0	0.00499	0	16	41										C	6008147	G	C	6008147	3	2	94	1	0	0	0	0	1	0	0	0	11125	942	33	1	979	1	OR52L1	11	6008147	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1596621	6008147	128998369	181	28208										
OR2D3	120775	broad.mit.edu	37	chr11	6943194	6943194	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggggctctcaggaaactagTtgggagaaagtgcttctctc	13	8	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:6943194T>C	uc010rav.1	+	1	962	c.962T>C	c.(961-963)GTT>GCT	p.V321A		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	321	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGGAAACTAGTTGGGAGAAAG	0.398													0	0	0	0.001855	0	14	30										C	6943194	T	C	6943194	3	2	94	1	0	0	0	0	1	0	0	0	10995	1725	60	5	964	5	OR2D3	11	6943194	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	935047	6943194	128063322	182	28209										
E2F8	79733	broad.mit.edu	37	chr11	19256582	19256582	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctctaggacgttcacgatatCgtaaatgcgtcgacgttcaa	9	10	3	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:19256582C>T	uc001mpm.2	-	5	997	c.475G>A	c.(475-477)GAT>AAT	p.D159N	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.D159N	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	159	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TTCACGATATCGTAAATGCGT	0.423													0	0	0	0.008291	0	9	21										T	19256582	C	T	19256582	3	4	94	1	0	0	0	0	1	0	0	0	4873	884	31	1	2164	1	E2F8	11	19256582	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	12313388	19256582	115749934	183	28210										
COMMD9	29099	broad.mit.edu	37	chr11	36297787	36297787	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gatcgaccaggcgtggcagaGagactgtggaaggaacagct	16	8	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:36297787G>C	uc001mwn.3	-	5	393	c.356C>G	c.(355-357)TCT>TGT	p.S119C	COMMD9_uc009ykj.2_Missense_Mutation_p.S77C|COMMD9_uc009yki.1_5'Flank	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	119										ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				GCGTGGCAGAGAGACTGTGGA	0.557													0	0	0	0.001855	0	12	32										C	36297787	G	C	36297787	3	2	94	1	0	0	0	0	1	0	0	0	3723	942	33	1	248	1	COMMD9	11	36297787	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	17041205	36297787	98708729	184	28211										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57075938	57075938	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtgtggctccaaggaagacGaggagtaatcttcaccctgg	14	9	2	1	rs141792675	byFrequency	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:57075938G>T	uc001njr.2	-	5	4559	c.4247C>A	c.(4246-4248)TCG>TAG	p.S1416*	TNKS1BP1_uc001njs.2_Nonsense_Mutation_p.S1416*|TNKS1BP1_uc009ymd.1_Nonsense_Mutation_p.S867*	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1416	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CAAGGAAGACGAGGAGTAATC	0.607													1	0	3.1745e-13	0.008361	5.90585e-13	32	219										T	57075938	G	T	57075938	4	4	94	1	0	0	0	0	0	1	0	0	16317	1059	37	3	966	3	TNKS1BP1	11	57075938	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	20778151	57075938	77930578	185	28212										
OR5A1	219982	broad.mit.edu	37	chr11	59211229	59211229	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgtcttgctctgacaccttCctcagtcaagtggtgaattt	8	11	4	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:59211229C>T	uc001nnx.1	+	1	588	c.588C>T	c.(586-588)TTC>TTT	p.F196F		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTGACACCTTCCTCAGTCAAG	0.512													0	0	0	0.00361	0	66	142										T	59211229	C	T	59211229	2	4	94	1	0	0	0	0	0	0	0	1	11139	854	30	1		1	OR5A1	11	59211229	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2135291	59211229	75795287	186	28213										
OR5A1	219982	broad.mit.edu	37	chr11	59211279	59211279	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtcactgtcggaggaacatCgttcctccaactccttatct	8	13	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:59211279C>A	uc001nnx.1	+	1	638	c.638C>A	c.(637-639)TCG>TAG	p.S213*		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GGAGGAACATCGTTCCTCCAA	0.542													1	0	4.00472e-15	0.00361	7.50757e-15	47	98										A	59211279	C	A	59211279	4	1	94	1	0	0	0	0	0	1	0	0	11139	893	31	3	640	3	OR5A1	11	59211279	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	50	59211279	75795237	187	28214										
GANAB	23193	broad.mit.edu	37	chr11	62396347	62396347	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcggattatatcattgtgctGagatggtaacagccatggct	11	7	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:62396347G>A	uc001nub.2	-	17	2107	c.2074C>T	c.(2074-2076)CAG>TAG	p.Q692*	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Nonsense_Mutation_p.Q714*|GANAB_uc001nuc.2_Nonsense_Mutation_p.Q595*|GANAB_uc010rma.1_Nonsense_Mutation_p.Q600*|GANAB_uc010rmb.1_Nonsense_Mutation_p.Q578*	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	692					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TCATTGTGCTGAGATGGTAAC	0.547													0	0	0	0.006999	0	40	101										A	62396347	G	A	62396347	4	1	94	1	0	0	0	0	0	1	0	0	6233	1299	45	1	792	1	GANAB	11	62396347	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3185068	62396347	72610169	188	28215										
NPAS4	266743	broad.mit.edu	37	chr11	66192075	66192075	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agggatgcagttttctctatGagaagttgcccccaagtcct	10	10	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:66192075G>A	uc001ohx.1	+	7	1890	c.1714G>A	c.(1714-1716)GAG>AAG	p.E572K	NPAS4_uc010rpc.1_Missense_Mutation_p.E362K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	572					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TTTTCTCTATGAGAAGTTGCC	0.602													0	0	0	0.005524	0	35	115										A	66192075	G	A	66192075	3	1	94	1	0	0	0	0	1	0	0	0	10565	1291	45	1	1740	1	NPAS4	11	66192075	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3795728	66192075	68814441	189	28216										
RBM14	10432	broad.mit.edu	37	chr11	66384516	66384516	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcggacgcgtcatcgagtgtGacgtggtgaaaggtaacgcg	17	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:66384516G>C	uc001oit.2	+	1	464	c.325G>C	c.(325-327)GAC>CAC	p.D109H	RBM14_uc009yrh.2_Missense_Mutation_p.D109H|RBM14_uc009yri.2_Missense_Mutation_p.D109H|RBM4_uc009yrj.2_5'UTR|RBM4_uc009yrk.2_Missense_Mutation_p.D109H	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	109	RRM 2.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CATCGAGTGTGACGTGGTGAA	0.652													0	0	0	0.006122	0	16	43										C	66384516	G	C	66384516	3	2	94	1	0	0	0	0	1	0	0	0	13115	1290	45	1	327	1	RBM14	11	66384516	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	192441	66384516	68622000	190	28217										
TBC1D10C	374403	broad.mit.edu	37	chr11	67173129	67173129	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttggcagggacctgcaccgtCaattccctctgcacgagatg	11	13	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:67173129C>G	uc001ola.2	+	5	453	c.424C>G	c.(424-426)CAA>GAA	p.Q142E	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Missense_Mutation_p.Q142E|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	142	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCTGCACCGTCAATTCCCTCT	0.647													0	0	0	0.00499	0	16	41										G	67173129	C	G	67173129	3	3	94	1	0	0	0	0	1	0	0	0	15597	827	29	1	438	1	TBC1D10C	11	67173129	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	788613	67173129	67833387	191	28218										
GSTP1	2950	broad.mit.edu	37	chr11	67353675	67353675	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggcaagaccttcattgtggGagaccaggtgagcatctggc	14	9	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:67353675G>T	uc001omf.2	+	6	686	c.437G>T	c.(436-438)GGA>GTA	p.G146V	GSTP1_uc001omg.1_Missense_Mutation_p.G127V	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	146	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TTCATTGTGGGAGACCAGGTG	0.567													1	0	2.17888e-05	0.006214	3.83922e-05	9	16										T	67353675	G	T	67353675	3	4	94	1	0	0	0	0	1	0	0	0	6844	1174	41	3	459	3	GSTP1	11	67353675	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	180546	67353675	67652841	192	28219										
SERPINH1	871	broad.mit.edu	37	chr11	75277666	75277666	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cggcaaggcgaccacggcgtCgcaggccaaggcagtgctga	16	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:75277666C>T	uc001owr.2	+	2	501	c.272C>T	c.(271-273)TCG>TTG	p.S91L	SERPINH1_uc009yuf.2_Missense_Mutation_p.S91L|SERPINH1_uc009yug.2_Missense_Mutation_p.S91L|SERPINH1_uc001ows.2_Missense_Mutation_p.S91L|SERPINH1_uc001owt.2_5'Flank	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	91					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					ACCACGGCGTCGCAGGCCAAG	0.701													0	0	0	0.001168	0	6	19										T	75277666	C	T	75277666	3	4	94	1	0	0	0	0	1	0	0	0	14117	893	31	1	274	1	SERPINH1	11	75277666	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	7923991	75277666	59728850	193	28220										
DLG2	1740	broad.mit.edu	37	chr11	83641425	83641425	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtagtgggaatagggagctGagaggaggaagcttttgtca	18	3	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:83641425G>C	uc001paj.2	-	10	1430	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Nonsense_Mutation_p.S343*|DLG2_uc010rsz.1_Nonsense_Mutation_p.S376*|DLG2_uc010rta.1_Nonsense_Mutation_p.S376*|DLG2_uc001pak.2_Nonsense_Mutation_p.S481*|DLG2_uc010rtb.1_Nonsense_Mutation_p.S343*|DLG2_uc001pal.1_Nonsense_Mutation_p.S376*|DLG2_uc001pam.1_Nonsense_Mutation_p.S415*	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	376						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				ATAGGGAGCTGAGAGGAGGAA	0.512													0	0	0	0.001882	0	19	51										C	83641425	G	C	83641425	4	2	94	1	0	0	0	0	0	1	0	0	4555	1294	45	1	1591	1	DLG2	11	83641425	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	8363759	83641425	51365091	194	28221										
TYR	7299	broad.mit.edu	37	chr11	89028453	89028453	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcttgctgtgtcgtcacaaGagaaagcagcttcctgaaga	11	9	1	3	rs138750983	byFrequency	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:89028453G>A	uc001pcs.2	+	5	1591	c.1509G>A	c.(1507-1509)AAG>AAA	p.K503K		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	503	Cytoplasmic (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GTCGTCACAAGAGAAAGCAGC	0.532									Oculocutaneous_Albinism				0	0	0	0.004482	0	8	26										A	89028453	G	A	89028453	2	1	94	1	0	0	0	0	0	0	0	1	16810	933	33	1		1	TYR	11	89028453	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5387028	89028453	45978063	195	28222										
DYNC2H1	79659	broad.mit.edu	37	chr11	103041631	103041631	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taagggcatcgatgtgaagtCaatgggacgaatatttgttg	13	4	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:103041631C>T	uc001pho.2	+	34	5312	c.5168C>T	c.(5167-5169)TCA>TTA	p.S1723L	DYNC2H1_uc001phn.1_Missense_Mutation_p.S1723L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1723	AAA 1 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GATGTGAAGTCAATGGGACGA	0.299													0	0	0	0.001984	0	7	20										T	103041631	C	T	103041631	3	4	94	1	0	0	0	0	1	0	0	0	4846	838	29	1	5302	1	DYNC2H1	11	103041631	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	14013178	103041631	31964885	196	28223										
DDI1	414301	broad.mit.edu	37	chr11	103908506	103908506	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tttcttacagtgctctttctCcatacttgaggatcaaccca	5	12	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:103908506C>G	uc001phr.2	+	1	1199	c.956C>G	c.(955-957)TCC>TGC	p.S319C	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	319					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGCTCTTTCTCCATACTTGAG	0.453													0	0	0	0.002836	0	33	86										G	103908506	C	G	103908506	3	3	94	1	0	0	0	0	1	0	0	0	4328	855	30	1	958	1	DDI1	11	103908506	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	866875	103908506	31098010	197	28224										
CADM1	23705	broad.mit.edu	37	chr11	115085457	115085457	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cccagacagtacggcgtgttGaggcatttcatcatcgactc	10	12	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:115085457G>C	uc001ppi.3	-	7	994	c.865C>G	c.(865-867)CAA>GAA	p.Q289E	CADM1_uc001ppf.3_Missense_Mutation_p.Q289E|CADM1_uc001ppk.3_Missense_Mutation_p.Q289E|CADM1_uc001ppj.3_Missense_Mutation_p.Q289E|CADM1_uc001ppl.2_Missense_Mutation_p.Q289E|CADM1_uc001pph.3_Missense_Mutation_p.Q41E	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	289	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ACGGCGTGTTGAGGCATTTCA	0.473													0	0	0	0.002836	0	28	71										C	115085457	G	C	115085457	3	2	94	1	0	0	0	0	1	0	0	0	2566	1299	45	1	479	1	CADM1	11	115085457	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	11176951	115085457	19921059	198	28225										
CD3E	916	broad.mit.edu	37	chr11	118185207	118185207	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgttcccaacccagactatGaggtaacgtgggatagaaat	10	9	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:118185207G>C	uc001psq.3	+	8	821	c.565G>C	c.(565-567)GAG>CAG	p.E189Q		NM_000733	NP_000724	P07766	CD3E_HUMAN	CD3E antigen, epsilon polypeptide precursor	189	Cytoplasmic (Potential).|ITAM.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	CCCAGACTATGAGGTAACGTG	0.557													0	0	0	0.004482	0	9	14										C	118185207	G	C	118185207	3	2	94	1	0	0	0	0	1	0	0	0	3011	1291	45	1	591	1	CD3E	11	118185207	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3099750	118185207	16821309	199	28226										
ABCG4	64137	broad.mit.edu	37	chr11	119029009	119029009	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	acacagttctgcatcctcttCaagaggaccttcctgtccat	6	14	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:119029009C>G	uc001pvs.2	+	10	1470	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	ABCG4_uc009zar.2_Missense_Mutation_p.F378L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	378	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCATCCTCTTCAAGAGGACCT	0.577													0	0	0	0.00361	0	94	183										G	119029009	C	G	119029009	3	3	94	1	0	0	0	0	1	0	0	0	70	825	29	1	1168	1	ABCG4	11	119029009	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	843802	119029009	15977507	200	28227										
TECTA	7007	broad.mit.edu	37	chr11	120980049	120980049	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgcacaatggaattcgaggcGagatctattacagagagacc	11	8	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:120980049G>C	uc010rzo.1	+	3	328	c.328G>C	c.(328-330)GAG>CAG	p.E110Q		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	110	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AATTCGAGGCGAGATCTATTA	0.512													0	0	0	0.001786	0	28	58										C	120980049	G	C	120980049	3	2	94	1	0	0	0	0	1	0	0	0	15744	1059	37	1	338	1	TECTA	11	120980049	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1951040	120980049	14026467	201	28228										
OR8B4	283162	broad.mit.edu	37	chr11	124294715	124294715	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gctggagctctggctgttctGataatcccacaaggataaac	10	10	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:124294715G>A	uc010sak.1	-	1	53	c.53C>T	c.(52-54)TCA>TTA	p.S18L		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGCTGTTCTGATAATCCCAC	0.478													0	0	0	0.00499	0	17	36										A	124294715	G	A	124294715	3	1	94	1	0	0	0	0	1	0	0	0	11229	1294	45	1	878	1	OR8B4	11	124294715	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3314666	124294715	10711801	202	28229										
SIAE	54414	broad.mit.edu	37	chr11	124524628	124524628	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgcttgaatgggagagacaGagaggatgcggacagactga	16	6	0	5			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:124524628G>A	uc001qan.2	-	4	580	c.467C>T	c.(466-468)TCT>TTT	p.S156F		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	156						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		GGGAGAGACAGAGAGGATGCG	0.488													0	0	0	0.00361	0	50	114										A	124524628	G	A	124524628	3	1	94	1	0	0	0	0	1	0	0	0	14298	942	33	1	1132	1	SIAE	11	124524628	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	229913	124524628	10481888	203	28230										
ROBO4	54538	broad.mit.edu	37	chr11	124766183	124766183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcccttcgtcactcttctctGctcttgccatcagcagggac	7	16	5	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:124766183G>A	uc001qbg.2	-	4	730	c.590C>T	c.(589-591)GCA>GTA	p.A197V	ROBO4_uc010sas.1_Missense_Mutation_p.A52V|ROBO4_uc001qbh.2_Missense_Mutation_p.A87V|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	197	Ig-like C2-type 2.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACTCTTCTCTGCTCTTGCCAT	0.617													0	0	0	0.002299	0	21	52										A	124766183	G	A	124766183	3	1	94	1	0	0	0	0	1	0	0	0	13516	1319	46	2	2493	2	ROBO4	11	124766183	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	241555	124766183	10240333	204	28231										
NTM	50863	broad.mit.edu	37	chr11	132082042	132082042	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagacacatctctcccaaagGtaagagaacagtttgttgca	9	9	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:132082042G>A	uc001qgp.2	+	3	1190	c.526_splice	c.e3+1	p.A176_splice	NTM_uc001qgm.2_Splice_Site_p.A176_splice|NTM_uc010sch.1_Splice_Site_p.A167_splice|NTM_uc010sci.1_Splice_Site_p.A176_splice|NTM_uc010scj.1_Splice_Site_p.A135_splice|NTM_uc001qgo.2_Splice_Site_p.A176_splice|NTM_uc001qgq.2_Splice_Site_p.A176_splice|NTM_uc001qgr.2_Splice_Site	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1						cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						TCTCCCAAAGGTAAGAGAACA	0.453													0	0	0	0.005524	0	35	89										A	132082042	G	A	132082042	5	1	94	1	0	0	0	0	0	0	1	0	10699	1275	44	2	623	2	NTM	11	132082042	Splice_Site	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7315859	132082042	2924474	205	28232										
KCNA1	3736	broad.mit.edu	37	chr12	5021124	5021124	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agacgctccccgagctgaagGatgacaaggacttcacgggc	13	12	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:5021124G>A	uc001qnh.2	+	2	1685	c.580G>A	c.(580-582)GAT>AAT	p.D194N		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	194					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGAGCTGAAGGATGACAAGGA	0.572													0	0	0	0.00499	0	18	30										A	5021124	G	A	5021124	3	1	94	1	0	0	0	0	1	0	0	0	8001	1174	41	1	582	1	KCNA1	12	5021124	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		5021124	128830771	206	28233										
CHD4	1108	broad.mit.edu	37	chr12	6690875	6690875	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccctggagtggagggtgtagGagtttttggggagggtgacc	20	5	0	1	rs143753094		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:6690875G>C	uc001qpo.2	-	31	4785	c.4621C>G	c.(4621-4623)CCT>GCT	p.P1541A	CHD4_uc001qpn.2_Missense_Mutation_p.P1534A|CHD4_uc001qpp.2_Missense_Mutation_p.P1566A|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1541					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GAGGGTGTAGGAGTTTTTGGG	0.547													0	0	0	0.008871	0	19	66										C	6690875	G	C	6690875	3	2	94	1	0	0	0	0	1	0	0	0	3327	1174	41	1	1157	1	CHD4	12	6690875	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1669751	6690875	127161020	207	28234										
CHD4	1108	broad.mit.edu	37	chr12	6692427	6692427	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gattctttttcctttgcccaGatttcgggctagatcttctt	7	10	3	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:6692427G>C	uc001qpo.2	-	26	4161	c.3997C>G	c.(3997-3999)CTG>GTG	p.L1333V	CHD4_uc001qpn.2_Missense_Mutation_p.L1326V|CHD4_uc001qpp.2_Missense_Mutation_p.L1330V|uc001qpq.1_3'UTR|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1333					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CCTTTGCCCAGATTTCGGGCT	0.537													0	0	0	0.00361	0	89	171										C	6692427	G	C	6692427	3	2	94	1	0	0	0	0	1	0	0	0	3327	933	33	1	1801	1	CHD4	12	6692427	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1552	6692427	127159468	208	28235										
KIAA1467	57613	broad.mit.edu	37	chr12	13219676	13219676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggaatctgattggtcctcagGtttacatcaccacaaatggg	10	9	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:13219676G>A	uc001rbi.2	+	6	978	c.955G>A	c.(955-957)GTT>ATT	p.V319I	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	319						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TGGTCCTCAGGTTTACATCAC	0.502													0	0	0	0.001368	0	12	42										A	13219676	G	A	13219676	3	1	94	1	0	0	0	0	1	0	0	0	8235	1261	44	2	977	2	KIAA1467	12	13219676	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	6527249	13219676	120632219	209	28236										
GUCY2C	2984	broad.mit.edu	37	chr12	14840914	14840914	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctgagtaggtcgaggccttCacaggtgctactccggcagt	13	12	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:14840914C>T	uc001rcd.2	-	2	438	c.301G>A	c.(301-303)GAA>AAA	p.E101K	GUCY2C_uc009zhz.2_Missense_Mutation_p.E101K	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	101	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TCGAGGCCTTCACAGGTGCTA	0.488													0	0	0	0.00632	0	25	76										T	14840914	C	T	14840914	3	4	94	1	0	0	0	0	1	0	0	0	6896	835	29	1	3024	1	GUCY2C	12	14840914	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1621238	14840914	119010981	210	28237										
C12orf72	254013	broad.mit.edu	37	chr12	31819050	31819050	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggataatcctgatgttgtcaGaggaaaatctgtattagatc	10	5	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:31819050G>A	uc009zjr.2	+	3	553	c.344G>A	c.(343-345)AGA>AAA	p.R115K	C12orf72_uc001rkl.2_Missense_Mutation_p.R115K|C12orf72_uc001rkm.2_Missense_Mutation_p.R115K	NM_001135864	NP_001129336	Q8IXQ9	MET20_HUMAN	hypothetical protein LOC254013	115						cytoplasm	protein methyltransferase activity				0						GATGTTGTCAGAGGAAAATCT	0.353													0	0	0	0.001855	0	14	31										A	31819050	G	A	31819050	3	1	94	1	0	0	0	0	1	0	0	0	1713	942	33	1	350	1	C12orf72	12	31819050	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	16978136	31819050	102032845	211	28238										
LRRK2	120892	broad.mit.edu	37	chr12	40716180	40716180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctctcatggaagaatggtttCctgggttgctggagattgat	13	6	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:40716180C>T	uc001rmg.3	+	37	5498	c.5377C>T	c.(5377-5379)CCT>TCT	p.P1793S	LRRK2_uc009zjw.2_Missense_Mutation_p.P631S|LRRK2_uc001rmi.2_Missense_Mutation_p.P626S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1793					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGAATGGTTTCCTGGGTTGCT	0.383													0	0	0	0.002222	0	40	109										T	40716180	C	T	40716180	3	4	94	1	0	0	0	0	1	0	0	0	9033	855	30	1	5523	1	LRRK2	12	40716180	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	8897130	40716180	93135715	212	28239										
ADAMTS20	80070	broad.mit.edu	37	chr12	43925874	43925874	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	acttcagagtctgcagaaaaGagttatttaagtcttgtctg	9	6	4	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:43925874G>A	uc010skx.1	-	3	578	c.578C>T	c.(577-579)TCT>TTT	p.S193F		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	193						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGCAGAAAAGAGTTATTTAA	0.328													0	0	0	0.001855	0	14	23										A	43925874	G	A	43925874	3	1	94	1	0	0	0	0	1	0	0	0	266	942	33	1	5301	1	ADAMTS20	12	43925874	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3209694	43925874	89926021	213	28240										
KRT8	3856	broad.mit.edu	37	chr12	53298670	53298670	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagaagctcgaggagctgatGcgggaaccgggcccactcgt	16	11	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:53298670G>A	uc001sbd.2	-	1	199	c.96C>T	c.(94-96)CGC>CGT	p.R32R	KRT8_uc009zmj.2_Silent_p.R32R|KRT8_uc009zmk.1_Silent_p.R60R|KRT8_uc009zml.1_Silent_p.R32R|KRT8_uc009zmm.1_Silent_p.R32R	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	32	Head.|Ser-rich.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAGCTGATGCGGGAACCGG	0.667													0	0	0	0.008291	0	11	13										A	53298670	G	A	53298670	2	1	94	1	0	0	0	0	0	0	0	1	8493	1306	46	2		2	KRT8	12	53298670	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9372796	53298670	80553225	214	28241										
TMEM194A	23306	broad.mit.edu	37	chr12	57453736	57453736	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctcctcagaggatgcttcctCatagatttcatcctgggcaa	8	12	3	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57453736C>T	uc001smy.2	-	9	1307	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K	TMEM194A_uc001smx.2_Missense_Mutation_p.E348K|TMEM194A_uc010sra.1_Missense_Mutation_p.E162K	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	421						integral to membrane					0						GATGCTTCCTCATAGATTTCA	0.463													0	0	0	0.001368	0	13	33										T	57453736	C	T	57453736	3	4	94	1	0	0	0	0	1	0	0	0	16113	835	29	1	77	1	TMEM194A	12	57453736	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4155066	57453736	76398159	215	28242										
TMEM194A	23306	broad.mit.edu	37	chr12	57453784	57453784	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccctaatccatactcctgctCatggacagaaacttcatttg	5	13	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57453784C>T	uc001smy.2	-	9	1259	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	TMEM194A_uc001smx.2_Missense_Mutation_p.E332K|TMEM194A_uc010sra.1_Missense_Mutation_p.E146K	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	405						integral to membrane					0						TACTCCTGCTCATGGACAGAA	0.448													0	0	0	0.003163	0	15	46										T	57453784	C	T	57453784	3	4	94	1	0	0	0	0	1	0	0	0	16113	835	29	1	125	1	TMEM194A	12	57453784	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	48	57453784	76398111	216	28243										
GLI1	2735	broad.mit.edu	37	chr12	57865455	57865455	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atgaaaattttgtagtggggGcaaatagggcttcacatagg	13	4	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57865455G>C	uc001snx.2	+	12	3010	c.2932G>C	c.(2932-2934)GCA>CCA	p.A978P	GLI1_uc009zpq.2_Missense_Mutation_p.A850P	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	978					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TGTAGTGGGGGCAAATAGGGC	0.537													0	0	0	0.003271	0	34	62										C	57865455	G	C	57865455	3	2	94	1	0	0	0	0	1	0	0	0	6437	1203	42	4	2974	4	GLI1	12	57865455	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	411671	57865455	75986440	217	28244										
ARHGAP9	64333	broad.mit.edu	37	chr12	57871349	57871349	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caggtgctgctcccaggcatCcagcctctgcagcagggggc	14	15	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57871349C>G	uc001sod.2	-	7	1055	c.862G>C	c.(862-864)GAT>CAT	p.D288H	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.D33H|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Missense_Mutation_p.D217H|ARHGAP9_uc001soc.2_Missense_Mutation_p.D217H|ARHGAP9_uc001soe.1_Missense_Mutation_p.D296H|ARHGAP9_uc010sro.1_Missense_Mutation_p.D217H	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	217	WW.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TCCCAGGCATCCAGCCTCTGC	0.642													0	0	0	0.001882	0	20	52										G	57871349	C	G	57871349	3	3	94	1	0	0	0	0	1	0	0	0	889	855	30	1	1606	1	ARHGAP9	12	57871349	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5894	57871349	75980546	218	28245										
LRRIQ1	84125	broad.mit.edu	37	chr12	85438530	85438530	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcagtttctaataatcatatGcatttaagaacaggactatc	6	7	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:85438530G>A	uc001tac.2	+	4	390	c.279G>A	c.(277-279)ATG>ATA	p.M93I	LRRIQ1_uc001tab.1_Missense_Mutation_p.M93I|LRRIQ1_uc001taa.1_Missense_Mutation_p.M93I|LRRIQ1_uc001tad.2_Missense_Mutation_p.M1I	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	93										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATAATCATATGCATTTAAGAA	0.259													0	0	0	0.008291	0	9	30										A	85438530	G	A	85438530	3	1	94	1	0	0	0	0	1	0	0	0	9029	1319	46	2	289	2	LRRIQ1	12	85438530	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	27567181	85438530	48413365	219	28246										
UBE3B	89910	broad.mit.edu	37	chr12	109927779	109927779	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcaaatataatgggacatctCaaccagcatggattttattc	7	8	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109927779C>G	uc001top.2	+	8	1203	c.600C>G	c.(598-600)CTC>CTG	p.L200L	UBE3B_uc001toq.2_Silent_p.L200L|UBE3B_uc001tol.1_Silent_p.L200L|UBE3B_uc001tom.2_Silent_p.L200L|UBE3B_uc001ton.2_Silent_p.L200L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L200L|UBE3B_uc001tor.2_Silent_p.L200L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	200					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TGGGACATCTCAACCAGCATG	0.428													0	0	0	0.001786	0	27	79										G	109927779	C	G	109927779	2	3	94	1	0	0	0	0	0	0	0	1	16877	813	29	1		1	UBE3B	12	109927779	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	24489249	109927779	23924116	220	28247										
UBE3B	89910	broad.mit.edu	37	chr12	109928922	109928922	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctttaacagcagctttttctCtagcgttacggtgagtaaga	9	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109928922C>G	uc001top.2	+	9	1306	c.703C>G	c.(703-705)CTA>GTA	p.L235V	UBE3B_uc001toq.2_Missense_Mutation_p.L235V|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.L235V	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	235					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						AGCTTTTTCTCTAGCGTTACG	0.428													0	0	0	0.004656	0	19	35										G	109928922	C	G	109928922	3	3	94	1	0	0	0	0	1	0	0	0	16877	912	32	1	729	1	UBE3B	12	109928922	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1143	109928922	23922973	221	28248										
UBE3B	89910	broad.mit.edu	37	chr12	109937445	109937445	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctctctctgtaggcaacctCctacacttgggctccctcag	7	16	3	0	rs150323950	by1000genomes	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109937445C>G	uc001top.2	+	12	1551	c.948C>G	c.(946-948)CTC>CTG	p.L316L	UBE3B_uc001toq.2_Silent_p.L316L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L316L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	316					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TAGGCAACCTCCTACACTTGG	0.582													0	0	0	0.001168	0	6	12										G	109937445	C	G	109937445	2	3	94	1	0	0	0	0	0	0	0	1	16877	842	30	1		1	UBE3B	12	109937445	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	8523	109937445	23914450	222	28249										
UBE3B	89910	broad.mit.edu	37	chr12	109939251	109939251	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctctgatccggatcttcttCtgtgacatcctgagcaagaa	8	12	4	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109939251C>A	uc001top.2	+	13	1797	c.1194C>A	c.(1192-1194)TTC>TTA	p.F398L	UBE3B_uc001toq.2_Missense_Mutation_p.F398L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.F398L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	398					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GGATCTTCTTCTGTGACATCC	0.562													1	0	2.91434e-09	0.004878	5.31395e-09	37	88										A	109939251	C	A	109939251	3	1	94	1	0	0	0	0	1	0	0	0	16877	912	32	3	1236	3	UBE3B	12	109939251	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1806	109939251	23912644	223	28250										
UBE3B	89910	broad.mit.edu	37	chr12	109961811	109961811	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtggacgtgccatttgcatCcttcttcctgagccaactgc	10	13	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109961811C>G	uc001top.2	+	22	2996	c.2393C>G	c.(2392-2394)TCC>TGC	p.S798C	UBE3B_uc001toq.2_Missense_Mutation_p.S798C|UBE3B_uc001tos.2_Missense_Mutation_p.S225C|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.S798C	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	798	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CCATTTGCATCCTTCTTCCTG	0.532													0	0	0	0.008361	0	28	101										G	109961811	C	G	109961811	3	3	94	1	0	0	0	0	1	0	0	0	16877	855	30	1	2471	1	UBE3B	12	109961811	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	22560	109961811	23890084	224	28251										
DYNLL1	8655	broad.mit.edu	37	chr12	120935923	120935923	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggcattgcatcgtggggagGaacttcggtagttatgtgac	15	6	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:120935923G>C	uc001tyj.2	+	3	434	c.180G>C	c.(178-180)AGG>AGC	p.R60S	uc001tyk.1_5'Flank|DYNLL1_uc001tyl.2_Missense_Mutation_p.R60S|DYNLL1_uc001tym.2_Missense_Mutation_p.R60S	NM_001037494	NP_001032583	P63167	DYL1_HUMAN	dynein light chain 1	60					actin cytoskeleton organization|activation of pro-apoptotic gene products|anatomical structure morphogenesis|female gamete generation|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|microtubule-based process|negative regulation of phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	centrosome|cytoplasmic dynein complex|cytosol|microtubule|mitochondrion|nucleus|plasma membrane	motor activity|protein binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCGTGGGGAGGAACTTCGGTA	0.418													0	0	0	0.006214	0	8	29										C	120935923	G	C	120935923	3	2	94	1	0	0	0	0	1	0	0	0	4848	1165	41	1	186	1	DYNLL1	12	120935923	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	10974112	120935923	12915972	225	28252										
ZNF664	144348	broad.mit.edu	37	chr12	124496822	124496822	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taagggtttctttcatatatCagaacttcatattcattgga	6	6	5	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:124496822C>T	uc001ufz.2	+	6	1961	c.131C>T	c.(130-132)TCA>TTA	p.S44L	ZNF664_uc001uga.2_Missense_Mutation_p.S44L|ZNF664_uc001ugb.2_Missense_Mutation_p.S44L	NM_152437	NP_689650	Q8N3J9	ZN664_HUMAN	zinc finger protein 664	44	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		TTTCATATATCAGAACTTCAT	0.353													0	0	0	0.00278	0	22	86										T	124496822	C	T	124496822	3	4	94	1	0	0	0	0	1	0	0	0	18069	838	29	1	133	1	ZNF664	12	124496822	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3560899	124496822	9355073	226	28253										
TMEM132B	114795	broad.mit.edu	37	chr12	125834167	125834167	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcccgggtggagccattcttCatctaccgagccaggacacc	11	15	3	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:125834167C>T	uc001uhe.1	+	2	230	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	74	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCCATTCTTCATCTACCGAG	0.512													0	0	0	0.00361	0	48	97										T	125834167	C	T	125834167	2	4	94	1	0	0	0	0	0	0	0	1	16043	825	29	1		1	TMEM132B	12	125834167	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1337345	125834167	8017728	227	28254										
IFT88	8100	broad.mit.edu	37	chr13	21175890	21175890	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttacatttattcaggctggtCagtattcagatgctattaat	7	6	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:21175890C>T	uc001unh.2	+	14	1282	c.886C>T	c.(886-888)CAG>TAG	p.Q296*	IFT88_uc001uni.2_Nonsense_Mutation_p.Q287*|IFT88_uc001unj.2_Nonsense_Mutation_p.Q286*|IFT88_uc010tcq.1_Nonsense_Mutation_p.Q267*|IFT88_uc001unk.2_Intron	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	296	TPR 3.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TCAGGCTGGTCAGTATTCAGA	0.338													0	0	0	0.001855	0	13	52										T	21175890	C	T	21175890	4	4	94	1	0	0	0	0	0	1	0	0	7566	827	29	1	932	1	IFT88	13	21175890	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		21175890	93993988	228	28255										
MTUS2	23281	broad.mit.edu	37	chr13	29599309	29599309	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gctgaaattccccggcatgtTcccaaggataaactggcaaa	9	11	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:29599309T>C	uc001usl.3	+	1	562	c.504T>C	c.(502-504)GTT>GTC	p.V168V		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	158						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CCCGGCATGTTCCCAAGGATA	0.507													0	0	0	0.005443	0	26	59										C	29599309	T	C	29599309	2	2	94	1	0	0	0	0	0	0	0	1	9966	1770	62	5		5	MTUS2	13	29599309	Silent	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	8423419	29599309	85570569	229	28256										
NHLRC3	387921	broad.mit.edu	37	chr13	39621205	39621205	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgctgaccgaggaaataaaaGaatccaagtatttgataaag	9	5	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:39621205G>C	uc001uxc.2	+	6	1029	c.707G>C	c.(706-708)AGA>ACA	p.R236T	NHLRC3_uc001uxd.2_Missense_Mutation_p.R169T|NHLRC3_uc001uxe.2_Missense_Mutation_p.R39T	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	236	NHL 3.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		GGAAATAAAAGAATCCAAGTA	0.358													0	0	0	0.001523	0	20	40										C	39621205	G	C	39621205	3	2	94	1	0	0	0	0	1	0	0	0	10407	942	33	1	729	1	NHLRC3	13	39621205	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	10021896	39621205	75548673	230	28257										
PCDH8	5100	broad.mit.edu	37	chr13	53422431	53422431	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgcaggtcctcggccagggtCccgatgaccgtgccgggggc	17	14	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:53422431C>T	uc001vhi.2	-	1	344	c.141G>A	c.(139-141)GGG>GGA	p.G47G	PCDH8_uc001vhj.2_Silent_p.G47G	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	47	Extracellular (Potential).|Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGGCCAGGGTCCCGATGACCG	0.602													0	0	0	0.00333	0	24	85										T	53422431	C	T	53422431	2	4	94	1	0	0	0	0	0	0	0	1	11517	842	30	1		1	PCDH8	13	53422431	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	13801226	53422431	61747447	231	28258										
GPC5	2262	broad.mit.edu	37	chr13	92560309	92560309	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ataaactgaagcatgttgttCaggtaagtcctgatcctata	8	7	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:92560309C>T	uc010tif.1	+	6	1765	c.1399C>T	c.(1399-1401)CAG>TAG	p.Q467*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	467						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCATGTTGTTCAGGTAAGTCC	0.313													0	0	0	0.00308	0	7	14										T	92560309	C	T	92560309	4	4	94	1	0	0	0	0	0	1	0	0	6601	827	29	1	1421	1	GPC5	13	92560309	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	39137878	92560309	22609569	232	28259										
GPC6	10082	broad.mit.edu	37	chr13	93879779	93879779	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctccctccccgccggggcgGatgtgaaggctcggagctgc	15	15	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:93879779G>A	uc001vlt.2	+	1	702	c.70G>A	c.(70-72)GAT>AAT	p.D24N	GPC6_uc010tig.1_Missense_Mutation_p.D24N	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	24						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CGCCGGGGCGGATGTGAAGGC	0.632											OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	12	41										A	93879779	G	A	93879779	3	1	94	1	0	0	0	0	1	0	0	0	6602	1174	41	1	72	1	GPC6	13	93879779	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1319470	93879779	21290099	233	28260										
UGGT2	55757	broad.mit.edu	37	chr13	96506627	96506627	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtatcctgttttccagaaacGatatccatccatttccctgc	5	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:96506627G>T	uc001vmt.2	-	35	4281	c.4111C>A	c.(4111-4113)CGT>AGT	p.R1371S	UGGT2_uc001vms.2_Missense_Mutation_p.R91S	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1371	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TTCCAGAAACGATATCCATCC	0.393													1	0	0.000442599	0.006214	0.000766963	9	31										T	96506627	G	T	96506627	3	4	94	1	0	0	0	0	1	0	0	0	16939	1058	37	3	459	3	UGGT2	13	96506627	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2626848	96506627	18663251	234	28261										
ZNF828	283489	broad.mit.edu	37	chr13	115090045	115090045	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	attggggccaccttcagcctCatctccagagtcaccagttc	8	15	4	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:115090045C>T	uc010ahb.2	+	3	1057	c.728C>T	c.(727-729)TCA>TTA	p.S243L	ZNF828_uc001vuv.2_Missense_Mutation_p.S243L|ZNF828_uc010tko.1_Missense_Mutation_p.S243L	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	243	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		CCTTCAGCCTCATCTCCAGAG	0.552													0	0	0	0.00623	0	40	67										T	115090045	C	T	115090045	3	4	94	1	0	0	0	0	1	0	0	0	18178	838	29	1	730	1	ZNF828	13	115090045	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	18583418	115090045	79833	235	28262										
OR4M1	441670	broad.mit.edu	37	chr14	20248955	20248955	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggcttcattcattctataatAcaggtggctctcattgttcg	8	9	4	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:20248955A>T	uc010tku.1	+	1	474	c.474A>T	c.(472-474)ATA>ATT	p.I158I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTCTATAATACAGGTGGCTC	0.502													0	0	0	0.006999	0	38	292										T	20248955	A	T	20248955	2	4	94	1	0	0	0	0	0	0	0	1	11075	381	14	5		5	OR4M1	14	20248955	Silent	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08		20248955	87100585	236	28263										
TGM1	7051	broad.mit.edu	37	chr14	24729739	24729739	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccccagcgtctgattgtgtgCggactgtgaactgaaacttg	12	10	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:24729739C>A	uc001wod.2	-	4	798	c.674G>T	c.(673-675)CGC>CTC	p.R225L	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	225			R -> P (in ARCI-TGM1).|R -> H (in ARCI-TGM1).		cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGATTGTGTGCGGACTGTGAA	0.587													1	0	1.2644e-06	0.001523	2.26604e-06	20	64										A	24729739	C	A	24729739	3	1	94	1	0	0	0	0	1	0	0	0	15826	768	27	4	1827	4	TGM1	14	24729739	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4480784	24729739	82619801	237	28264										
FANCM	57697	broad.mit.edu	37	chr14	45642298	45642298	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aattcatcaactctctctctCtgaatggagactgtggcaag	8	10	5	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:45642298C>G	uc001wwd.3	+	13	2300	c.2201C>G	c.(2200-2202)TCT>TGT	p.S734C	FANCM_uc010anf.2_Missense_Mutation_p.S708C|FANCM_uc001wwe.3_Missense_Mutation_p.S270C|FANCM_uc010ang.2_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	734					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						CTCTCTCTCTCTGAATGGAGA	0.363								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.002299	0	22	42										G	45642298	C	G	45642298	3	3	94	1	0	0	0	0	1	0	0	0	5671	913	32	1	2251	1	FANCM	14	45642298	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	20912559	45642298	61707242	238	28265										
PYGL	5836	broad.mit.edu	37	chr14	51378884	51378884	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gctgactcacggttgtacatCgtgatcacatgcagacagtt	10	10	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:51378884C>T	uc001wyu.2	-	14	1885	c.1758G>A	c.(1756-1758)ACG>ACA	p.T586T	PYGL_uc010tqq.1_Silent_p.T552T|PYGL_uc001wyv.2_Silent_p.T260T	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	586					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GGTTGTACATCGTGATCACAT	0.512													0	0	0	0.001786	0	32	95										T	51378884	C	T	51378884	2	4	94	1	0	0	0	0	0	0	0	1	12861	871	31	1		1	PYGL	14	51378884	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5736586	51378884	55970656	239	28266										
KCNH5	27133	broad.mit.edu	37	chr14	63447854	63447854	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggaaccataatggcggtgtaGaaggtaagaattaaaatcac	11	5	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:63447854G>C	uc001xfx.2	-	6	729	c.678C>G	c.(676-678)TTC>TTG	p.F226L	KCNH5_uc001xfy.2_Missense_Mutation_p.F226L|KCNH5_uc001xfz.1_Missense_Mutation_p.F168L|KCNH5_uc001xga.2_Missense_Mutation_p.F168L	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	226	Helical; Name=Segment S1; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGGCGGTGTAGAAGGTAAGAA	0.388													0	0	0	0.007291	0	26	29										C	63447854	G	C	63447854	3	2	94	1	0	0	0	0	1	0	0	0	8035	933	33	1	2346	1	KCNH5	14	63447854	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	12068970	63447854	43901686	240	28267										
SYNE2	23224	broad.mit.edu	37	chr14	64588835	64588835	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aacatgataacgatacaactCaggaatcatctgcaaggtaa	7	8	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:64588835C>G	uc001xgm.2	+	69	13494	c.13264C>G	c.(13264-13266)CAG>GAG	p.Q4422E	SYNE2_uc001xgl.2_Missense_Mutation_p.Q4422E|SYNE2_uc010apy.2_Missense_Mutation_p.Q807E|SYNE2_uc010apz.1_Missense_Mutation_p.Q314E	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4422	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CGATACAACTCAGGAATCATC	0.328													0	0	0	0.006999	0	39	56										G	64588835	C	G	64588835	3	3	94	1	0	0	0	0	1	0	0	0	15443	827	29	1	13534	1	SYNE2	14	64588835	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1140981	64588835	42760705	241	28268										
ACTN1	87	broad.mit.edu	37	chr14	69387726	69387726	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccagaggtaggccttaccttCggctccgatggacaccagtt	11	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:69387726C>T	uc001xkl.2	-	3	647	c.337G>A	c.(337-339)GAA>AAA	p.E113K	ACTN1_uc010ttb.1_Missense_Mutation_p.E48K|ACTN1_uc001xkm.2_Missense_Mutation_p.E113K|ACTN1_uc001xkn.2_Missense_Mutation_p.E113K|ACTN1_uc001xko.1_Missense_Mutation_p.E48K|ACTN1_uc010ttd.1_Missense_Mutation_p.E92K	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	113	CH 1.|Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GCCTTACCTTCGGCTCCGATG	0.557													0	0	0	0.008361	0	28	99										T	69387726	C	T	69387726	3	4	94	1	0	0	0	0	1	0	0	0	204	893	31	1	2487	1	ACTN1	14	69387726	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4798891	69387726	37961814	242	28269										
ANGEL1	23357	broad.mit.edu	37	chr14	77273020	77273020	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgtcccaggccttctgggacGagtggttgcagtagcaacac	13	11	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:77273020G>A	uc001xsv.2	-	5	1232	c.1119C>T	c.(1117-1119)CTC>CTT	p.L373L	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	373										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CTTCTGGGACGAGTGGTTGCA	0.577													0	0	0	0.00361	0	62	72										A	77273020	G	A	77273020	2	1	94	1	0	0	0	0	0	0	0	1	608	1045	37	1		1	ANGEL1	14	77273020	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7885294	77273020	30076520	243	28270										
SERPINA4	5267	broad.mit.edu	37	chr14	95033521	95033521	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aaccaaggcaaaatgagggaGattgaagaggttctgactcc	12	7	1	5			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:95033521G>C	uc001ydk.2	+	3	930	c.864G>C	c.(862-864)GAG>GAC	p.E288D	SERPINA4_uc010avd.2_Missense_Mutation_p.E325D|SERPINA4_uc001ydl.2_Missense_Mutation_p.E288D	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	288					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		AAATGAGGGAGATTGAAGAGG	0.468													0	0	0	0.003163	0	15	27										C	95033521	G	C	95033521	3	2	94	1	0	0	0	0	1	0	0	0	14091	933	33	1	870	1	SERPINA4	14	95033521	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	17760501	95033521	12316019	244	28271										
CLMN	79789	broad.mit.edu	37	chr14	95669499	95669499	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggggaacctcatagtgtggGaaatagaagaggtcgtgggg	18	4	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:95669499G>A	uc001yef.2	-	9	2303	c.2187C>T	c.(2185-2187)TTC>TTT	p.F729F		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	729						integral to membrane	actin binding				0				Epithelial(152;0.193)		CATAGTGTGGGAAATAGAAGA	0.522													0	0	0	0.006122	0	18	42										A	95669499	G	A	95669499	2	1	94	1	0	0	0	0	0	0	0	1	3542	1165	41	1		1	CLMN	14	95669499	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	635978	95669499	11680041	245	28272										
CTDSPL2	51496	broad.mit.edu	37	chr15	44788618	44788618	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggttattcatcagcccacgcGgaggccacctatgaagaaga	11	11	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:44788618G>A	uc001ztr.2	+	6	1148	c.732G>A	c.(730-732)GCG>GCA	p.A244A	CTDSPL2_uc001zts.2_Silent_p.A244A|CTDSPL2_uc001ztt.2_Silent_p.A244A|CTDSPL2_uc010bdv.2_Silent_p.A172A	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	244							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		CAGCCCACGCGGAGGCCACCT	0.363													0	0	0	0.003163	0	14	34										A	44788618	G	A	44788618	2	1	94	1	0	0	0	0	0	0	0	1	4006	1103	39	2		2	CTDSPL2	15	44788618	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		44788618	57742774	246	28273										
ATP8B4	79895	broad.mit.edu	37	chr15	50152596	50152596	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aagcatagccagaccttcttGagcttgacctgcgggtccga	11	12	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:50152596G>C	uc001zxu.2	-	28	3516	c.3374C>G	c.(3373-3375)TCA>TGA	p.S1125*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.S998*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.S935*|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Nonsense_Mutation_p.S128*	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1125	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AGACCTTCTTGAGCTTGACCT	0.522													0	0	0	0.001523	0	21	55										C	50152596	G	C	50152596	4	2	94	1	0	0	0	0	0	1	0	0	1197	1294	45	1	208	1	ATP8B4	15	50152596	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5363978	50152596	52378796	247	28274										
ATP8B4	79895	broad.mit.edu	37	chr15	50189570	50189570	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttatagaagaaatagcataaGaatttgcacattcggaaata	7	4	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:50189570G>C	uc001zxu.2	-	23	2758	c.2616C>G	c.(2614-2616)TTC>TTG	p.F872L	ATP8B4_uc010ber.2_Missense_Mutation_p.F745L|ATP8B4_uc010ufd.1_Missense_Mutation_p.F682L|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Missense_Mutation_p.F170L	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	872	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AATAGCATAAGAATTTGCACA	0.378													0	0	0	0.00361	0	68	140										C	50189570	G	C	50189570	3	2	94	1	0	0	0	0	1	0	0	0	1197	933	33	1	986	1	ATP8B4	15	50189570	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	36974	50189570	52341822	248	28275										
HDC	3067	broad.mit.edu	37	chr15	50535004	50535004	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caacccgagggctgggttggGaagtacagtgctgactcagg	16	9	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:50535004G>A	uc001zxz.2	-	12	1548	c.1442C>T	c.(1441-1443)TCC>TTC	p.S481F	HDC_uc001zxy.2_Missense_Mutation_p.S224F|HDC_uc010uff.1_Missense_Mutation_p.S448F	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	481					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	GCTGGGTTGGGAAGTACAGTG	0.552													0	0	0	0.001368	0	13	31										A	50535004	G	A	50535004	3	1	94	1	0	0	0	0	1	0	0	0	7015	1174	41	1	550	1	HDC	15	50535004	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	345434	50535004	51996388	249	28276										
IGDCC3	9543	broad.mit.edu	37	chr15	65667594	65667594	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caaggtggagtgggtactctCtggcagctctaccccattct	11	12	3	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:65667594C>A	uc002aos.2	-	2	502	c.250G>T	c.(250-252)GAG>TAG	p.E84*		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	84	Extracellular (Potential).|Ig-like C2-type 1.									ovary(3)	3						TGGGTACTCTCTGGCAGCTCT	0.602													1	0	1.04858e-14	0.006214	1.96073e-14	9	23										A	65667594	C	A	65667594	4	1	94	1	0	0	0	0	0	1	0	0	7568	922	32	3	2246	3	IGDCC3	15	65667594	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	15132590	65667594	36863798	250	28277										
KIF23	9493	broad.mit.edu	37	chr15	69728485	69728485	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tttgtgttttagcaagtcatGagatttgcggaagtgactca	11	5	2	2	rs149564859		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:69728485G>A	uc002asb.2	+	13	1398	c.1281G>A	c.(1279-1281)ATG>ATA	p.M427I	KIF23_uc002asc.2_Missense_Mutation_p.M427I|KIF23_uc010bii.2_Missense_Mutation_p.M317I|KIF23_uc010ukc.1_Missense_Mutation_p.M244I|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	427					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						AGCAAGTCATGAGATTTGCGG	0.368													0	0	0	0.00499	0	15	44										A	69728485	G	A	69728485	3	1	94	1	0	0	0	0	1	0	0	0	8291	1290	45	1	1331	1	KIF23	15	69728485	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	4060891	69728485	32802907	251	28278										
THSD4	79875	broad.mit.edu	37	chr15	72039333	72039333	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctgagaccaccagcacctgCcaactcaagatctgcagcga	8	16	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:72039333C>G	uc002atb.1	+	12	2272	c.2193C>G	c.(2191-2193)TGC>TGG	p.C731W	THSD4_uc002ate.2_Missense_Mutation_p.C371W	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	731	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CCAGCACCTGCCAACTCAAGA	0.657													0	0	0	0.006214	0	7	12										G	72039333	C	G	72039333	3	3	94	1	0	0	0	0	1	0	0	0	15875	747	26	4	2239	4	THSD4	15	72039333	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2310848	72039333	30492059	252	28279										
ISLR2	57611	broad.mit.edu	37	chr15	74425108	74425108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagccgcgatgttcccccttCgggccctgtggttggtctgg	15	13	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:74425108C>T	uc002axd.2	+	4	782	c.13C>T	c.(13-15)CGG>TGG	p.R5W	ISLR2_uc002axe.2_Missense_Mutation_p.R5W|ISLR2_uc010bjg.2_Missense_Mutation_p.R5W|ISLR2_uc010bjf.2_Missense_Mutation_p.R5W	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	5					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GTTCCCCCTTCGGGCCCTGTG	0.622													0	0	0	0.001855	0	12	24										T	74425108	C	T	74425108	3	4	94	1	0	0	0	0	1	0	0	0	7859	875	31	1	15	1	ISLR2	15	74425108	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2385775	74425108	28106284	253	28280										
DNAJA4	55466	broad.mit.edu	37	chr15	78566699	78566699	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgcatcaaccccaaggaccgCtgcgagagctgcagcggggc	14	15	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:78566699C>T	uc002bdj.1	+	4	696	c.579C>T	c.(577-579)CGC>CGT	p.R193R	DNAJA4_uc002bdi.2_Silent_p.R222R|DNAJA4_uc002bdk.2_Silent_p.R166R|DNAJA4_uc002bdl.2_Silent_p.R108R|DNAJA4_uc002bdm.1_5'Flank	NM_001130182	NP_001123654	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	193	CR-type.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			skin(1)	1						CCAAGGACCGCTGCGAGAGCT	0.597													0	0	0	0.006122	0	18	36										T	78566699	C	T	78566699	2	4	94	1	0	0	0	0	0	0	0	1	4614	784	28	2		2	DNAJA4	15	78566699	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4141591	78566699	23964693	254	28281										
FSD2	123722	broad.mit.edu	37	chr15	83447543	83447543	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atggtgttaatggagcccatCagctgctccacatcagagaa	10	10	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:83447543C>T	uc002bjd.2	-	6	1253	c.1086G>A	c.(1084-1086)CTG>CTA	p.L362L	FSD2_uc010uol.1_Silent_p.L362L|FSD2_uc010uom.1_Silent_p.L362L	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	362										central_nervous_system(1)	1						TGGAGCCCATCAGCTGCTCCA	0.423													0	0	0	0.004482	0	9	17										T	83447543	C	T	83447543	2	4	94	1	0	0	0	0	0	0	0	1	6071	813	29	1		1	FSD2	15	83447543	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4880844	83447543	19083849	255	28282										
ACAN	176	broad.mit.edu	37	chr15	89402347	89402347	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tccaccaccaccagtgatgtGgggacagaggcaccaggctt	12	13	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:89402347G>A	uc010upo.1	+	12	6905	c.6531G>A	c.(6529-6531)GTG>GTA	p.V2177V	ACAN_uc010upp.1_Silent_p.V2177V|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2177					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCAGTGATGTGGGGACAGAGG	0.607													0	0	0	0.007413	0	19	60										A	89402347	G	A	89402347	2	1	94	1	0	0	0	0	0	0	0	1	117	1335	47	2		2	ACAN	15	89402347	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5954804	89402347	13129045	256	28283										
PDIA2	64714	broad.mit.edu	37	chr16	335191	335191	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atgcgcctggtcacggagttCaacagccaggtgcgtaggct	14	11	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:335191C>G	uc002cgn.1	+	10	1894	c.786C>G	c.(784-786)TTC>TTG	p.F262L	PDIA2_uc010bqt.1_Missense_Mutation_p.F107L|PDIA2_uc002cgo.1_Missense_Mutation_p.F262L	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	262					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				TCACGGAGTTCAACAGCCAGG	0.662													0	0	0	0.001984	0	7	29										G	335191	C	G	335191	3	3	94	1	0	0	0	0	1	0	0	0	11668	825	29	1	804	1	PDIA2	16	335191	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		335191	90019562	257	28284										
CHTF18	63922	broad.mit.edu	37	chr16	844108	844108	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gacacactcctgctgggtgaCggggacgcgggctccctcac	14	15	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:844108C>T	uc002cke.3	+	15	1920	c.1857C>T	c.(1855-1857)GAC>GAT	p.D619D	CHTF18_uc002ckf.3_Silent_p.D647D|CHTF18_uc010brf.2_Silent_p.D201D|CHTF18_uc002ckg.3_Silent_p.D137D	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	619					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				TGCTGGGTGACGGGGACGCGG	0.662													0	0	0	0.001855	0	13	56										T	844108	C	T	844108	2	4	94	1	0	0	0	0	0	0	0	1	3414	535	19	2		2	CHTF18	16	844108	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	508917	844108	89510645	258	28285										
TBC1D24	57465	broad.mit.edu	37	chr16	2546212	2546212	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atggacgctgccatccaggaCctggggcccaaggagctgag	15	12	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:2546212C>T	uc002cql.2	+	2	203	c.63C>T	c.(61-63)GAC>GAT	p.D21D	TBC1D24_uc002cqk.2_Silent_p.D21D|TBC1D24_uc002cqm.2_Silent_p.D21D|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	21					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CCATCCAGGACCTGGGGCCCA	0.637													0	0	0	0.008871	0	20	36										T	2546212	C	T	2546212	2	4	94	1	0	0	0	0	0	0	0	1	15611	506	18	2		2	TBC1D24	16	2546212	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1702104	2546212	87808541	259	28286										
TBC1D24	57465	broad.mit.edu	37	chr16	2546956	2546956	+	Missense_Mutation	SNP	C	C	G													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gacagcgtgaagcaggacatCcgcacgttcgtcagagacat							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:2546956C>G	uc002cql.2	+	2	947	c.807C>G	c.(805-807)ATC>ATG	p.I269M	TBC1D24_uc002cqk.2_Missense_Mutation_p.I269M|TBC1D24_uc002cqm.2_Missense_Mutation_p.I269M|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	269					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						AGCAGGACATCCGCACGTTCG	0.622													0	0	0	0.006122	0	14	54										G	2546956	C	G	2546956	3	3	94	1	0	0	0	0	1	0	0	0	15611	845	30	1	809	1	TBC1D24	16	2546956	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	744	2546956	87807797	260	28287	140	2								
TBC1D24	57465	broad.mit.edu	37	chr16	2546965	2546965	+	Silent	SNP	C	C	T													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aagcaggacatccgcacgttCgtcagagacatcgcgaagac							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:2546965C>T	uc002cql.2	+	2	956	c.816C>T	c.(814-816)TTC>TTT	p.F272F	TBC1D24_uc002cqk.2_Silent_p.F272F|TBC1D24_uc002cqm.2_Silent_p.F272F|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	272					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						TCCGCACGTTCGTCAGAGACA	0.622													0	0	0	0.004007	0	14	50										T	2546965	C	T	2546965	2	4	94	1	0	0	0	0	0	0	0	1	15611	883	31	1		1	TBC1D24	16	2546965	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	9	2546965	87807788	261	28288	140	2								
TNRC6A	27327	broad.mit.edu	37	chr16	24816470	24816470	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctcctccattactctcccctCaggtaaataagctttcctta	3	15	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:24816470C>T	uc002dmm.2	+	14	4234	c.4120C>T	c.(4120-4122)CAG>TAG	p.Q1374*	TNRC6A_uc010bxs.2_Nonsense_Mutation_p.Q1121*|TNRC6A_uc002dmn.2_Nonsense_Mutation_p.Q1072*|TNRC6A_uc002dmo.2_Nonsense_Mutation_p.Q1013*|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_Nonsense_Mutation_p.Q41*	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1374					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ACTCTCCCCTCAGGTAAATAA	0.438													0	0	0	0.007291	0	27	76										T	24816470	C	T	24816470	4	4	94	1	0	0	0	0	0	1	0	0	16337	827	29	1	4174	1	TNRC6A	16	24816470	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	22269505	24816470	65538283	262	28289										
GTF3C1	2975	broad.mit.edu	37	chr16	27475748	27475748	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtcttcctgtgctgctcccGctgcagcggtgtcttcaaga	12	13	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:27475748G>A	uc002dov.1	-	34	5805	c.5765C>T	c.(5764-5766)GCG>GTG	p.A1922V	GTF3C1_uc002dou.2_Missense_Mutation_p.A1922V	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1922						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TGCTGCTCCCGCTGCAGCGGT	0.642													0	0	0	0.00361	0	46	120										A	27475748	G	A	27475748	3	1	94	1	0	0	0	0	1	0	0	0	6872	1087	38	2	580	2	GTF3C1	16	27475748	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2659278	27475748	62879005	263	28290										
SH2B1	25970	broad.mit.edu	37	chr16	28878727	28878727	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccacagccctggagatgcctGaccgggagaacacgtttgtg	13	12	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:28878727G>C	uc002dri.2	+	5	1454	c.1015G>C	c.(1015-1017)GAC>CAC	p.D339H	uc010vct.1_Intron|SH2B1_uc010vdc.1_Missense_Mutation_p.D29H|SH2B1_uc002drj.2_Missense_Mutation_p.D339H|SH2B1_uc002drk.2_Missense_Mutation_p.D339H|SH2B1_uc002drl.2_Missense_Mutation_p.D339H|SH2B1_uc010vdd.1_Missense_Mutation_p.D3H|SH2B1_uc010vde.1_Missense_Mutation_p.D339H|SH2B1_uc002drm.2_Missense_Mutation_p.D339H	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	339	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|PH.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGAGATGCCTGACCGGGAGAA	0.547													0	0	0	0.00361	0	53	145										C	28878727	G	C	28878727	3	2	94	1	0	0	0	0	1	0	0	0	14227	1290	45	1	1021	1	SH2B1	16	28878727	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1402979	28878727	61476026	264	28291										
MVP	9961	broad.mit.edu	37	chr16	29852959	29852959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cctacatgctgacccaggacGaagtcctgtgggagaaagag	13	10	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:29852959G>A	uc002dui.2	+	9	1318	c.1234G>A	c.(1234-1236)GAA>AAA	p.E412K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.E412K|MVP_uc010vea.1_Missense_Mutation_p.E6K	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	412	MVP 8.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GACCCAGGACGAAGTCCTGTG	0.617													0	0	0	0.001368	0	12	20										A	29852959	G	A	29852959	3	1	94	1	0	0	0	0	1	0	0	0	9996	1059	37	1	1264	1	MVP	16	29852959	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	974232	29852959	60501794	265	28292										
ZNF768	79724	broad.mit.edu	37	chr16	30535908	30535908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctgggagaaggcctttccgCagtcatcgcacttgtaaggc	12	11	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:30535908C>T	uc002dyk.3	-	2	1729	c.1553G>A	c.(1552-1554)TGC>TAC	p.C518Y	ZNF768_uc010vex.1_Missense_Mutation_p.C487Y|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.C487Y	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	518	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GGCCTTTCCGCAGTCATCGCA	0.692													0	0	0	0.001368	0	11	32										T	30535908	C	T	30535908	3	4	94	1	0	0	0	0	1	0	0	0	18138	710	25	2	73	2	ZNF768	16	30535908	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	682949	30535908	59818845	266	28293										
OGFOD1	55239	broad.mit.edu	37	chr16	56509430	56509430	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcttgtaaggctgggagccaGaatatggcggttttacttct	12	7	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:56509430G>A	uc002ejb.2	+	12	1521	c.1420G>A	c.(1420-1422)GAA>AAA	p.E474K	OGFOD1_uc002ejc.2_Missense_Mutation_p.E334K	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	474							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	CTGGGAGCCAGAATATGGCGG	0.383													0	0	0	0.00361	0	41	63										A	56509430	G	A	56509430	3	1	94	1	0	0	0	0	1	0	0	0	10841	943	33	1	1466	1	OGFOD1	16	56509430	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	25973522	56509430	33845323	267	28294										
SLC9A5	6553	broad.mit.edu	37	chr16	67298323	67298323	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cggcaggacaaggaggtcttCcagcagaacatgaagcggcg	15	10	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:67298323C>T	uc002esm.2	+	13	1974	c.1911C>T	c.(1909-1911)TTC>TTT	p.F637F	SLC9A5_uc010cee.2_Silent_p.F342F|SLC9A5_uc010vji.1_Silent_p.F141F	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	637					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		AGGAGGTCTTCCAGCAGAACA	0.587													0	0	0	0.006214	0	8	20										T	67298323	C	T	67298323	2	4	94	1	0	0	0	0	0	0	0	1	14717	854	30	1		1	SLC9A5	16	67298323	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	10788893	67298323	23056430	268	28295										
CTCF	10664	broad.mit.edu	37	chr16	67654676	67654676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagtttgtgcagttatgccaGcagggacacatacaagctga	11	9	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:67654676G>A	uc002etl.2	+	6	1453	c.1163G>A	c.(1162-1164)AGC>AAC	p.S388N	CTCF_uc010cek.2_Missense_Mutation_p.S60N	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	388	C2H2-type 5.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGTTATGCCAGCAGGGACACA	0.443													0	0	0	0.001523	0	22	52										A	67654676	G	A	67654676	3	1	94	1	0	0	0	0	1	0	0	0	4000	971	34	2	1177	2	CTCF	16	67654676	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	356353	67654676	22700077	269	28296										
ACD	65057	broad.mit.edu	37	chr16	67692069	67692069	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gagagactgggagtgcagctCtggagtggggagctgggggt	22	5	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:67692069C>T	uc002etq.3	-	10	1621	c.1284G>A	c.(1282-1284)CAG>CAA	p.Q428Q	ACD_uc002etp.3_Silent_p.Q425Q|ACD_uc002etr.3_Silent_p.Q425Q|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	428	Ser-rich.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GAGTGCAGCTCTGGAGTGGGG	0.642													0	0	0	0.00499	0	13	29										T	67692069	C	T	67692069	2	4	94	1	0	0	0	0	0	0	0	1	135	912	32	1		1	ACD	16	67692069	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	37393	67692069	22662684	270	28297										
SPIRE2	84501	broad.mit.edu	37	chr16	89895104	89895104	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgtgtgcttccagggctgccGcgggctgcggggctcgccgg	19	14	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:89895104G>A	uc002foz.1	+	1	198	c.146G>A	c.(145-147)CGC>CAC	p.R49H	SPIRE2_uc010civ.1_5'UTR|SPIRE2_uc010ciw.1_Missense_Mutation_p.R49H	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	49	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CAGGGCTGCCGCGGGCTGCGG	0.552													0	0	0	0.000602	0	4	8										A	89895104	G	A	89895104	3	1	94	1	0	0	0	0	1	0	0	0	15071	1087	38	2	148	2	SPIRE2	16	89895104	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	22203035	89895104	459649	271	28298										
ITGAE	3682	broad.mit.edu	37	chr17	3661136	3661136	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttctcctggagccgtggcttGaggtgaagatgctgtctcta	13	9	2	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:3661136G>C	uc002fwo.3	-	9	983	c.884C>G	c.(883-885)TCA>TGA	p.S295*		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	295	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GCCGTGGCTTGAGGTGAAGAT	0.522													0	0	0	0.002522	0	44	56										C	3661136	G	C	3661136	4	2	94	1	0	0	0	0	0	1	0	0	7885	1294	45	1	2747	1	ITGAE	17	3661136	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		3661136	77534074	272	28299										
TP53	7157	broad.mit.edu	37	chr17	7577548	7577548	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gatgggcctccggttcatgcCgcccatgcaggaactgttac	12	13	1	0	rs28934575		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.007291	0	25	23										T	7577548	C	T	7577548	3	4	94	1	0	0	0	0	1	0	0	0	16378	652	23	2	557	2	TP53	17	7577548	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3916412	7577548	73617662	273	28300										
MAP2K3	5606	broad.mit.edu	37	chr17	21204234	21204234	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agcagaagcggctgctcatgGacctggacatcaacatgcgc	12	12	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:21204234G>A	uc002gys.2	+	5	593	c.328G>A	c.(328-330)GAC>AAC	p.D110N	MAP2K3_uc002gyt.2_Missense_Mutation_p.D81N|MAP2K3_uc002gyu.2_Missense_Mutation_p.D81N	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	110	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GCTGCTCATGGACCTGGACAT	0.587													0	0	0	0.008291	0	11	80										A	21204234	G	A	21204234	3	1	94	1	0	0	0	0	1	0	0	0	9238	1174	41	1	346	1	MAP2K3	17	21204234	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	13626686	21204234	59990976	274	28301										
CSF3	1440	broad.mit.edu	37	chr17	38173107	38173107	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cagggtgccatgccggccttCgcctctgctttccagcgccg	12	17	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:38173107C>T	uc002htp.2	+	5	559	c.519C>T	c.(517-519)TTC>TTT	p.F173F	CSF3_uc002hto.2_Silent_p.F170F|CSF3_uc002htq.2_Silent_p.F166F|CSF3_uc010wep.1_Silent_p.F130F	NM_000759	NP_000750	P09919	CSF3_HUMAN	colony stimulating factor 3 isoform a precursor	173					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			ovary(1)	1	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGCCGGCCTTCGCCTCTGCTT	0.647													0	0	0	0.004656	0	25	45										T	38173107	C	T	38173107	2	4	94	1	0	0	0	0	0	0	0	1	3936	883	31	1		1	CSF3	17	38173107	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	16968873	38173107	43022103	275	28302										
NR1D1	9572	broad.mit.edu	37	chr17	38253437	38253437	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggatgacgacgaggaagatGaggaagaaggggagccgtca	18	5	1	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:38253437G>C	uc002htz.1	-	2	877	c.251C>G	c.(250-252)TCA>TGA	p.S84*	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_5'Flank	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	84	Poly-Ser.				cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					cgaggaagatgaggaagaagg	0.478													0	0	0	0.00245	0	15	38										C	38253437	G	C	38253437	4	2	94	1	0	0	0	0	0	1	0	0	10615	1294	45	1	1621	1	NR1D1	17	38253437	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	80330	38253437	42941773	276	28303										
TNS4	84951	broad.mit.edu	37	chr17	38645050	38645050	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gccccctgccctggttcccaGagaagatgaggctctcactg	11	15	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:38645050G>C	uc010cxb.2	-	3	775	c.611C>G	c.(610-612)TCT>TGT	p.S204C		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	204	Ser-rich.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CTGGTTCCCAGAGAAGATGAG	0.647													0	0	0	0.00278	0	22	44										C	38645050	G	C	38645050	3	2	94	1	0	0	0	0	1	0	0	0	16342	942	33	1	1580	1	TNS4	17	38645050	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	391613	38645050	42550160	277	28304										
KRTAP9-8	83901	broad.mit.edu	37	chr17	39394660	39394660	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgcctggttgcctaaaccaGagctgtggctccaactgctg	11	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:39394660G>C	uc002hwh.3	+	1	391	c.357G>C	c.(355-357)CAG>CAC	p.Q119H	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	119	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCCTAAACCAGAGCTGTGGCT	0.622													0	0	0	0.005524	0	30	66										C	39394660	G	C	39394660	3	2	94	1	0	0	0	0	1	0	0	0	8576	933	33	1	359	1	KRTAP9-8	17	39394660	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	749610	39394660	41800550	278	28305										
BRIP1	83990	broad.mit.edu	37	chr17	59763374	59763374	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtactttaaagaggtcacttCaagtgtagactcattgtcct	8	8	3	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:59763374C>G	uc002izk.1	-	19	2869	c.2728G>C	c.(2728-2730)GAA>CAA	p.E910Q	BRIP1_uc002izl.1_Missense_Mutation_p.E291Q	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	910	Interaction with BRCA1.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						GAGGTCACTTCAAGTGTAGAC	0.368			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00361	0	83	101										G	59763374	C	G	59763374	3	3	94	1	0	0	0	0	1	0	0	0	1514	835	29	1	1029	1	BRIP1	17	59763374	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	20368714	59763374	21431836	279	28306										
MED13	9969	broad.mit.edu	37	chr17	60111268	60111268	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgtttccattcaccaattaAtttttttgtagctgaatcag	5	8	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:60111268A>T	uc002izo.2	-	5	771	c.694T>A	c.(694-696)TTA>ATA	p.L232I		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	232					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCACCAATTAATTTTTTTGTA	0.383													0	0	0	0.00499	0	17	49										T	60111268	A	T	60111268	3	4	94	1	0	0	0	0	1	0	0	0	9430	98	4	5	5934	5	MED13	17	60111268	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	347894	60111268	21083942	280	28307										
ABCA9	10350	broad.mit.edu	37	chr17	66988371	66988371	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcagttcatttctaggcatcGcagaatgaaaagaaaaatga	9	6	2	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:66988371G>A	uc002jhu.2	-	28	3804	c.3661C>T	c.(3661-3663)CGA>TGA	p.R1221*	ABCA9_uc010dez.2_Nonsense_Mutation_p.R1183*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1221					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCTAGGCATCGCAGAATGAAA	0.318													0	0	0	0.001168	0	6	20										A	66988371	G	A	66988371	4	1	94	1	0	0	0	0	0	1	0	0	39	1095	38	2	1261	2	ABCA9	17	66988371	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	6877103	66988371	14206839	281	28308										
OTOP3	347741	broad.mit.edu	37	chr17	72937560	72937560	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agccccggagaaggagaaccGagtggatgtgggggccgagg	20	8	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:72937560G>A	uc010wrr.1	+	2	146	c.146G>A	c.(145-147)CGA>CAA	p.R49Q	OTOP3_uc010wrq.1_Missense_Mutation_p.R31Q	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	49						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					AAGGAGAACCGAGTGGATGTG	0.552													0	0	0	0.000602	0	4	14										A	72937560	G	A	72937560	3	1	94	1	0	0	0	0	1	0	0	0	11307	1058	37	1	152	1	OTOP3	17	72937560	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	5949189	72937560	8257650	282	28309										
MIF4GD	57409	broad.mit.edu	37	chr17	73263627	73263627	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggggccacccacctcctcctCcttgctcaaactgtctggct	8	18	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:73263627C>G	uc002jnr.2	-	5	562	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	MIF4GD_uc002jno.2_Missense_Mutation_p.E186Q|MIF4GD_uc002jnp.2_Missense_Mutation_p.E179Q|MIF4GD_uc002jnq.2_Missense_Mutation_p.E186Q			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	145	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			ACCTCCTCCTCCTTGCTCAAA	0.612													0	0	0	0.008871	0	19	62										G	73263627	C	G	73263627	3	3	94	1	0	0	0	0	1	0	0	0	9584	864	30	1	243	1	MIF4GD	17	73263627	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	326067	73263627	7931583	283	28310										
TRIM65	201292	broad.mit.edu	37	chr17	73887139	73887139	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggctgtcctcctggacgcaGagcccccaggagcagggtcc	14	15	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:73887139G>C	uc002jpx.2	-	6	1311	c.1275C>G	c.(1273-1275)CTC>CTG	p.L425L		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	425	B30.2/SPRY.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTGGACGCAGAGCCCCCAGG	0.687													0	0	0	0.004482	0	9	19										C	73887139	G	C	73887139	2	2	94	1	0	0	0	0	0	0	0	1	16536	929	33	1		1	TRIM65	17	73887139	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	623512	73887139	7308071	284	28311										
TMC6	11322	broad.mit.edu	37	chr17	76113638	76113638	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caggagaccctggggcctgcCgcctccaggtggcgcaccca	14	17	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:76113638C>T	uc002juj.1	-	16	2235	c.2109G>A	c.(2107-2109)GCG>GCA	p.A703A	TMC6_uc002jui.1_Silent_p.A282A|TMC6_uc010dhf.1_Silent_p.A536A|TMC6_uc002juk.2_Silent_p.A703A|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Silent_p.A703A	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	703	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGGGGCCTGCCGCCTCCAGGT	0.667									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.000602	0	4	9										T	76113638	C	T	76113638	2	4	94	1	0	0	0	0	0	0	0	1	15986	639	23	2		2	TMC6	17	76113638	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2226499	76113638	5081572	285	28312										
ACTG1	71	broad.mit.edu	37	chr17	79479123	79479123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gccacgcttgctctgggcctCgtcgcccacgtaggagtcct	12	16	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:79479123C>T	uc002kaj.1	-	2	194	c.169G>A	c.(169-171)GAG>AAG	p.E57K	ACTG1_uc002kah.1_5'Flank|ACTG1_uc002kai.1_Missense_Mutation_p.E14K|ACTG1_uc002kak.1_Missense_Mutation_p.E57K|ACTG1_uc010wun.1_Missense_Mutation_p.E57K|ACTG1_uc002kal.1_Missense_Mutation_p.E57K|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	57					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CTCTGGGCCTCGTCGCCCACG	0.642													0	0	0	0.00361	0	50	27										T	79479123	C	T	79479123	3	4	94	1	0	0	0	0	1	0	0	0	196	893	31	1	974	1	ACTG1	17	79479123	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3365485	79479123	1716087	286	28313										
ZNF750	79755	broad.mit.edu	37	chr17	80788479	80788479	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggttctgcagctcgtggtcGaccggggaaggcaggcctcg	17	11	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:80788479G>A	uc002kga.2	-	3	2022	c.1711C>T	c.(1711-1713)CGA>TGA	p.R571*	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	571						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTCGTGGTCGACCGGGGAAG	0.622													0	0	0	0.008361	0	23	36										A	80788479	G	A	80788479	4	1	94	1	0	0	0	0	0	1	0	0	18129	1066	37	1	464	1	ZNF750	17	80788479	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1309356	80788479	406731	287	28314										
LAMA3	3909	broad.mit.edu	37	chr18	21508633	21508633	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agaggaggacaattgagtttCactgatttgggcttaccacc	11	8	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr18:21508633C>T	uc002kuq.2	+	64	8426	c.8340C>T	c.(8338-8340)TTC>TTT	p.F2780F	LAMA3_uc002kur.2_Silent_p.F2724F|LAMA3_uc002kus.3_Silent_p.F1171F|LAMA3_uc002kut.3_Silent_p.F1115F	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2780	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGAGTTTCACTGATTTGG	0.423													0	0	0	0.00361	0	50	72										T	21508633	C	T	21508633	2	4	94	1	0	0	0	0	0	0	0	1	8607	825	29	1		1	LAMA3	18	21508633	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		21508633	56568615	288	28315										
CD226	10666	broad.mit.edu	37	chr18	67563226	67563226	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgacaagtgagtgtgacattCtttccaggttccgaaacaat	9	8	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr18:67563226C>G	uc010dqo.2	-	3	885	c.438G>C	c.(436-438)AAG>AAC	p.K146N	CD226_uc002lkm.3_Missense_Mutation_p.K146N	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	146	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				GTGTGACATTCTTTCCAGGTT	0.458													0	0	0	0.001882	0	18	32										G	67563226	C	G	67563226	3	3	94	1	0	0	0	0	1	0	0	0	2986	912	32	1	588	1	CD226	18	67563226	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	46054593	67563226	10514022	289	28316										
ADNP2	22850	broad.mit.edu	37	chr18	77894028	77894028	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gacatacacagagatttggaGaataagcttagatctgtgat	10	5	1	4			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr18:77894028G>A	uc002lnw.2	+	4	1187	c.732G>A	c.(730-732)GAG>GAA	p.E244E		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	244					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GAGATTTGGAGAATAAGCTTA	0.423													0	0	0	0.001855	0	14	40										A	77894028	G	A	77894028	2	1	94	1	0	0	0	0	0	0	0	1	324	933	33	1		1	ADNP2	18	77894028	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	10330802	77894028	183220	290	28317										
APC2	10297	broad.mit.edu	37	chr19	1456894	1456894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgtccatgttggcgacgcgcGaccaggaggatacagcgcgc	15	12	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:1456894G>A	uc002lsr.1	+	9	1067	c.859G>A	c.(859-861)GAC>AAC	p.D287N	APC2_uc002lss.1_5'UTR|APC2_uc002lst.1_Missense_Mutation_p.D287N|APC2_uc002lsu.1_Missense_Mutation_p.D286N	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	287					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGACGCGCGACCAGGAGGA	0.677													0	0	0	0.000602	0	5	1										A	1456894	G	A	1456894	3	1	94	1	0	0	0	0	1	0	0	0	764	1058	37	1	889	1	APC2	19	1456894	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		1456894	57672089	291	28318										
C19orf36	113177	broad.mit.edu	37	chr19	2097472	2097472	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttccgggagcaggtgcacctCatccagaacgccatcatcga	10	14	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:2097472C>T	uc002luw.1	+	3	425	c.348C>T	c.(346-348)CTC>CTT	p.L116L	C19orf36_uc002lux.1_Silent_p.L116L|C19orf36_uc010xgw.1_Silent_p.L116L	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	116						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGCACCTCATCCAGAACG	0.607											OREG0025135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	15	42										T	2097472	C	T	2097472	2	4	94	1	0	0	0	0	0	0	0	1	1921	813	29	1		1	C19orf36	19	2097472	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	640578	2097472	57031511	292	28319										
UHRF1	29128	broad.mit.edu	37	chr19	4941939	4941939	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcagtgttcccagcgaggacGagtggtgagtgcggccctgc	17	11	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:4941939G>C	uc002mbo.2	+	7	1237	c.1069G>C	c.(1069-1071)GAG>CAG	p.E357Q	UHRF1_uc010xik.1_RNA|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.E370Q	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	357	PHD-type.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CAGCGAGGACGAGTGGTGAGT	0.612													0	0	0	0.004672	0	2	4										C	4941939	G	C	4941939	3	2	94	1	0	0	0	0	1	0	0	0	16964	1059	37	1	1130	1	UHRF1	19	4941939	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2844467	4941939	54187044	293	28320										
HNRNPM	4670	broad.mit.edu	37	chr19	8533687	8533687	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gccttaccaaaaggagatttCttccctcctgagcgtccaca	7	14	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:8533687C>T	uc010dwe.2	+	9	944	c.864C>T	c.(862-864)TTC>TTT	p.F288F	HNRNPM_uc010dwc.1_Silent_p.F288F|HNRNPM_uc010xke.1_Silent_p.F249F|HNRNPM_uc010dwd.2_Silent_p.F249F|HNRNPM_uc002mka.2_Silent_p.F168F	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	288					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						AAGGAGATTTCTTCCCTCCTG	0.323													0	0	0	0.00632	0	24	47										T	8533687	C	T	8533687	2	4	94	1	0	0	0	0	0	0	0	1	7271	912	32	1		1	HNRNPM	19	8533687	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3591748	8533687	50595296	294	28321										
COL5A3	50509	broad.mit.edu	37	chr19	10116382	10116382	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	catctatgctgacggccacaCggtgccacctgcaaggggac	12	14	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:10116382C>G	uc002mmq.1	-	4	532	c.446G>C	c.(445-447)CGT>CCT	p.R149P		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	149	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GACGGCCACACGGTGCCACCT	0.627													0	0	0	0.001984	0	7	23										G	10116382	C	G	10116382	3	3	94	1	0	0	0	0	1	0	0	0	3698	536	19	4	5047	4	COL5A3	19	10116382	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1582695	10116382	49012601	295	28322										
KEAP1	9817	broad.mit.edu	37	chr19	10602630	10602630	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttgggcgcccggcagggcatCacctgcgtgggcttgtgcag	17	12	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:10602630C>T	uc002moq.1	-	3	1104	c.948G>A	c.(946-948)GTG>GTA	p.V316V	KEAP1_uc002mop.1_Silent_p.V34V|KEAP1_uc002mor.1_Silent_p.V316V	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGCAGGGCATCACCTGCGTGG	0.637													0	0	0	0.008291	0	10	36										T	10602630	C	T	10602630	2	4	94	1	0	0	0	0	0	0	0	1	8141	813	29	1		1	KEAP1	19	10602630	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	486248	10602630	48526353	296	28323										
KEAP1	9817	broad.mit.edu	37	chr19	10602926	10602926	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggacaggttgaagaactcctCttgcttggccacctgcagag	12	11	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:10602926C>G	uc002moq.1	-	3	808	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.E218Q	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	218	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.E218Q(1)		lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AAGAACTCCTCTTGCTTGGCC	0.557													0	0	0	0.000602	0	4	16										G	10602926	C	G	10602926	3	3	94	1	0	0	0	0	1	0	0	0	8141	922	32	1	1238	1	KEAP1	19	10602926	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	296	10602926	48526057	297	28324										
ZNF439	90594	broad.mit.edu	37	chr19	11978815	11978815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaaaagcattcatgtgtcccCgttatgttcgtagacatgaa	9	8	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:11978815C>T	uc002mss.2	+	3	1059	c.931C>T	c.(931-933)CGT>TGT	p.R311C	ZNF439_uc002msr.2_Missense_Mutation_p.R175C	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	311	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CATGTGTCCCCGTTATGTTCG	0.413													0	0	0	0.008871	0	17	66										T	11978815	C	T	11978815	3	4	94	1	0	0	0	0	1	0	0	0	17908	652	23	2	941	2	ZNF439	19	11978815	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1375889	11978815	47150168	298	28325										
CRLF1	9244	broad.mit.edu	37	chr19	18705144	18705144	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttggagcagtacgcgtgcttCttgagccagcccaggaactg	13	11	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:18705144C>T	uc010ebt.1	-	7	1319	c.1125G>A	c.(1123-1125)AAG>AAA	p.K375K		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	375					negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						ACGCGTGCTTCTTGAGCCAGC	0.577													0	0	0	0.00308	0	8	22										T	18705144	C	T	18705144	2	4	94	1	0	0	0	0	0	0	0	1	3886	912	32	1		1	CRLF1	19	18705144	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	6726329	18705144	40423839	299	28326										
SF4	57794	broad.mit.edu	37	chr19	19407889	19407889	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcttcaggcccccaccggctCttccgcttcctcttcacggt	7	19	5	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:19407889C>G	uc002nmh.2	-	8	1154	c.1152G>C	c.(1150-1152)AAG>AAC	p.K384N	SF4_uc002nmf.2_5'UTR|SF4_uc002nmg.2_5'UTR|SF4_uc002nmi.2_Missense_Mutation_p.K174N|SF4_uc002nmj.2_Missense_Mutation_p.K174N|SF4_uc010xqr.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	384	Nuclear localization signal (Potential).				nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						CCCACCGGCTCTTCCGCTTCC	0.667													0	0	0	0.007413	0	17	27										G	19407889	C	G	19407889	3	3	94	1	0	0	0	0	1	0	0	0	14155	912	32	1	813	1	SF4	19	19407889	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	702745	19407889	39721094	300	28327										
NPHS1	4868	broad.mit.edu	37	chr19	36322242	36322242	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcctgtccactggctctcctCatattcgttcctgactcggt	7	15	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:36322242C>T	uc002oby.2	-	26	3343	c.3343G>A	c.(3343-3345)GAG>AAG	p.E1115K	NPHS1_uc010eem.1_RNA	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1115	Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGCTCTCCTCATATTCGTTC	0.627													0	0	0	0.002445	0	32	52										T	36322242	C	T	36322242	3	4	94	1	0	0	0	0	1	0	0	0	10582	835	29	1	398	1	NPHS1	19	36322242	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	16914353	36322242	22806741	301	28328										
CATSPERG	57828	broad.mit.edu	37	chr19	38851428	38851428	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcaagaggctcgtgcccgtgGagcagcttctgatgtatcaa	12	10	3	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:38851428G>A	uc002oih.3	+	16	1912	c.1825G>A	c.(1825-1827)GAG>AAG	p.E609K	CATSPERG_uc002oig.3_Missense_Mutation_p.E569K|CATSPERG_uc002oif.3_Missense_Mutation_p.E249K|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	609	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CGTGCCCGTGGAGCAGCTTCT	0.577													0	0	0	0.001168	0	4	11										A	38851428	G	A	38851428	3	1	94	1	0	0	0	0	1	0	0	0	2692	1175	41	1	1883	1	CATSPERG	19	38851428	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2529186	38851428	20277555	302	28329										
RYR1	6261	broad.mit.edu	37	chr19	39071143	39071143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaagtgtgatgacatgatgaCggtgagcccctcccctagca	12	11	0	5			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:39071143C>T	uc002oit.2	+	101	14775	c.14645C>T	c.(14644-14646)ACG>ATG	p.T4882M	RYR1_uc002oiu.2_Missense_Mutation_p.T4877M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4882	Helical; Name=M9; (Potential).				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GACATGATGACGGTGAGCCCC	0.313													0	0	0	0.002299	0	23	34										T	39071143	C	T	39071143	3	4	94	1	0	0	0	0	1	0	0	0	13768	550	19	2	15047	2	RYR1	19	39071143	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	219715	39071143	20057840	303	28330										
DLL3	10683	broad.mit.edu	37	chr19	39995950	39995950	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgagcggggtgacatgtgcaGatggaccctgcttcaacggc	15	10	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:39995950G>C	uc002olx.2	+	6	1010	c.952G>C	c.(952-954)GAT>CAT	p.D318H	DLL3_uc010egq.2_Missense_Mutation_p.D318H|DLL3_uc002olw.2_Missense_Mutation_p.D318H	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	318	EGF-like 3.|Extracellular (Potential).				Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GACATGTGCAGATGGACCCTG	0.617													0	0	0	0.006999	0	35	61										C	39995950	G	C	39995950	3	2	94	1	0	0	0	0	1	0	0	0	4567	942	33	1	974	1	DLL3	19	39995950	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	924807	39995950	19133033	304	28331										
CYP2B6	1555	broad.mit.edu	37	chr19	41522600	41522600	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcccgtgcggaattgttcctCttcttcaccaccatcctcca	6	17	3	0	rs138937514		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:41522600C>A	uc002opr.1	+	9	1351	c.1344C>A	c.(1342-1344)CTC>CTA	p.L448L	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.L248L	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	448					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AATTGTTCCTCTTCTTCACCA	0.572													1	0	4.68919e-08	0.008291	8.46595e-08	11	15										A	41522600	C	A	41522600	2	1	94	1	0	0	0	0	0	0	0	1	4164	900	32	3		3	CYP2B6	19	41522600	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1526650	41522600	17606383	305	28332										
CEACAM8	1088	broad.mit.edu	37	chr19	43097693	43097693	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtcatggggaatcactcacGatgtacgctgaactggccag	13	10	3	1	rs146875157	byFrequency	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:43097693G>A	uc002oud.2	-	2	526	c.424C>T	c.(424-426)CCG>TCG	p.P142S	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	142	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				AATCACTCACGATGTACGCTG	0.498													0	0	0	0.002096	0	33	64										A	43097693	G	A	43097693	3	1	94	1	0	0	0	0	1	0	0	0	3198	1072	37	1	641	1	CEACAM8	19	43097693	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1575093	43097693	16031290	306	28333										
RTN2	6253	broad.mit.edu	37	chr19	45998201	45998201	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgcgacgtggtctcctcctCgtcctcctctgagaattccc	8	17	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:45998201C>A	uc002pcb.2	-	3	370	c.142G>T	c.(142-144)GAG>TAG	p.E48*	RTN2_uc002pcc.2_Nonsense_Mutation_p.E48*|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	48						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		GTCTCCTCCTCGTCCTCCTCT	0.617													1	0	4.72057e-08	0.003954	8.50167e-08	25	31										A	45998201	C	A	45998201	4	1	94	1	0	0	0	0	0	1	0	0	13726	893	31	3	1531	3	RTN2	19	45998201	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2900508	45998201	13130782	307	28334										
GPR4	2828	broad.mit.edu	37	chr19	46094676	46094676	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgtcatggaacaggggcgccGagttggcgcccagctccgtg	16	13	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:46094676G>C	uc002pcm.2	-	2	1394	c.449C>G	c.(448-450)TCG>TGG	p.S150W	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	150	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		CAGGGGCGCCGAGTTGGCGCC	0.667													0	0	0	0.00333	0	23	65										C	46094676	G	C	46094676	3	2	94	1	0	0	0	0	1	0	0	0	6694	1059	37	1	643	1	GPR4	19	46094676	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	96475	46094676	13034307	308	28335										
IRF2BP1	26145	broad.mit.edu	37	chr19	46388452	46388452	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcttctctttctcgaaatcgGagccgaagaggggacgggca	14	10	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:46388452G>C	uc002pds.1	-	1	925	c.581C>G	c.(580-582)TCC>TGC	p.S194C		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CTCGAAATCGGAGCCGAAGAG	0.647													0	0	0	0.002096	0	29	85										C	46388452	G	C	46388452	3	2	94	1	0	0	0	0	1	0	0	0	7829	1174	41	1	1177	1	IRF2BP1	19	46388452	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	293776	46388452	12740531	309	28336										
PRRG2	5639	broad.mit.edu	37	chr19	50086939	50086939	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aagagaggtgttcctgggaaGaggccagggagtattttgag	17	4	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:50086939G>A	uc002pon.3	+	3	391	c.226G>A	c.(226-228)GAG>AAG	p.E76K	PRRG2_uc010yaz.1_Missense_Mutation_p.E53K	NM_000951	NP_000942	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	76	Gla.|Extracellular (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		TTCCTGGGAAGAGGCCAGGGA	0.577													0	0	0	0.005443	0	26	60										A	50086939	G	A	50086939	3	1	94	1	0	0	0	0	1	0	0	0	12606	943	33	1	232	1	PRRG2	19	50086939	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3698487	50086939	9042044	310	28337										
GPR32	2854	broad.mit.edu	37	chr19	51274256	51274256	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gccagtaactgcctccttgtCttcatctctgtggaccgttg	9	13	3	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:51274256C>G	uc010ycf.1	+	1	399	c.399C>G	c.(397-399)GTC>GTG	p.V133V		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	133	Helical; Name=3; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCCTCCTTGTCTTCATCTCTG	0.577													0	0	0	0.003214	0	42	106										G	51274256	C	G	51274256	2	3	94	1	0	0	0	0	0	0	0	1	6688	900	32	1		1	GPR32	19	51274256	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1187317	51274256	7854727	311	28338										
KLK6	5653	broad.mit.edu	37	chr19	51470546	51470546	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agatgtcttgtcgcagggtcCgccatgcaccaacttattct	9	12	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:51470546C>T	uc002pui.2	-	4	336	c.76G>A	c.(76-78)GGA>AGA	p.G26R	KLK6_uc010eoj.2_Missense_Mutation_p.G26R|KLK6_uc002puh.2_Missense_Mutation_p.G35R|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Missense_Mutation_p.G26R|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	26	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TCGCAGGGTCCGCCATGCACC	0.572													0	0	0	0.003271	0	34	16										T	51470546	C	T	51470546	3	4	94	1	0	0	0	0	1	0	0	0	8408	661	23	2	674	2	KLK6	19	51470546	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	196290	51470546	7658437	312	28339										
SIGLEC6	946	broad.mit.edu	37	chr19	52023405	52023405	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcctgaggttgcaccttgtgGaagtgtaggacagcgtagtg	15	7	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:52023405G>T	uc002pwy.2	-	8	1455	c.1293C>A	c.(1291-1293)TTC>TTA	p.F431L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.F415L|SIGLEC6_uc002pxa.2_3'UTR|SIGLEC6_uc010ydb.1_Missense_Mutation_p.F368L|SIGLEC6_uc010ydc.1_3'UTR|SIGLEC6_uc010eoz.1_3'UTR	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	431	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GCACCTTGTGGAAGTGTAGGA	0.502													1	0	9.84934e-19	0.002522	1.86071e-18	42	141										T	52023405	G	T	52023405	3	4	94	1	0	0	0	0	1	0	0	0	14312	1165	41	3	72	3	SIGLEC6	19	52023405	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	552859	52023405	7105578	313	28340										
ZNF175	7728	broad.mit.edu	37	chr19	52090205	52090205	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tttacagaaagtttgaagctGaacctagaagtgaacggtca	10	6	1	5			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:52090205G>A	uc002pxb.2	+	5	999	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	207					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GTTTGAAGCTGAACCTAGAAG	0.443													0	0	0	0.008871	0	18	61										A	52090205	G	A	52090205	2	1	94	1	0	0	0	0	0	0	0	1	17742	1277	45	1		1	ZNF175	19	52090205	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	66800	52090205	7038778	314	28341										
LILRA2	11027	broad.mit.edu	37	chr19	55086014	55086014	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctacagccacaatcactcatCagagtacagtgaccccctgg	7	15	3	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:55086014C>G	uc002qgg.3	+	3	406	c.317C>G	c.(316-318)TCA>TGA	p.S106*	LILRA2_uc010ern.2_Nonsense_Mutation_p.S106*|LILRA2_uc002qgf.2_Nonsense_Mutation_p.S106*|LILRA2_uc010yfe.1_Nonsense_Mutation_p.S106*|LILRA2_uc010yff.1_Nonsense_Mutation_p.S94*|LILRA2_uc010ero.2_Nonsense_Mutation_p.S94*|LILRA2_uc010yfg.1_Nonsense_Mutation_p.S106*	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	106	Extracellular (Potential).|Ig-like C2-type 1.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		AATCACTCATCAGAGTACAGT	0.592													0	0	0	0.00245	0	15	30										G	55086014	C	G	55086014	4	3	94	1	0	0	0	0	0	1	0	0	8785	838	29	1	327	1	LILRA2	19	55086014	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2995809	55086014	4042969	315	28342										
PPP1R12C	54776	broad.mit.edu	37	chr19	55607503	55607503	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcgctccttggacaagtcctGgagggaaatcttctcgcgac	12	12	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:55607503G>A	uc002qix.2	-	8	1085	c.1069C>T	c.(1069-1071)CAG>TAG	p.Q357*	PPP1R12C_uc010yfs.1_Nonsense_Mutation_p.Q283*|PPP1R12C_uc002qiy.2_Nonsense_Mutation_p.Q357*	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	357						cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GACAAGTCCTGGAGGGAAATC	0.672													0	0	0	0.008871	0	19	40										A	55607503	G	A	55607503	4	1	94	1	0	0	0	0	0	1	0	0	12356	1357	47	2	1339	2	PPP1R12C	19	55607503	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	521489	55607503	3521480	316	28343										
TGM6	343641	broad.mit.edu	37	chr20	2377244	2377244	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaggcgtggagaagcacataCgagcccagggctggaactac	15	10	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:2377244C>T	uc002wfy.1	+	4	578	c.517C>T	c.(517-519)CGA>TGA	p.R173*	TGM6_uc010gal.1_Nonsense_Mutation_p.R173*	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	173					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GAAGCACATACGAGCCCAGGG	0.612													0	0	0	0.001984	0	7	39										T	2377244	C	T	2377244	4	4	94	1	0	0	0	0	0	1	0	0	15831	528	19	2	531	2	TGM6	20	2377244	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		2377244	60648276	317	28344										
CDS2	8760	broad.mit.edu	37	chr20	5170443	5170443	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgctttgactgccagtatctGatggccacctttgtcaatgt	9	11	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:5170443G>C	uc002wls.2	+	12	1421	c.1164G>C	c.(1162-1164)CTG>CTC	p.L388L	CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Nonstop_Mutation_p.*340S|CDS2_uc010zqu.1_Silent_p.L268L|CDS2_uc002wlv.2_Silent_p.L290L|CDS2_uc010zqv.1_Silent_p.L158L	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	388					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						GCCAGTATCTGATGGCCACCT	0.468													0	0	0	0.003214	0	45	157										C	5170443	G	C	5170443	2	2	94	1	0	0	0	0	0	0	0	1	3178	1277	45	1		1	CDS2	20	5170443	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2793199	5170443	57855077	318	28345										
HAO1	54363	broad.mit.edu	37	chr20	7866353	7866353	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcatttctttgtccagttacCtggaaagctaagccccaaac	6	12	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:7866353C>G	uc002wmw.1	-	6	996	c.972G>C	c.(970-972)CAG>CAC	p.Q324H	HAO1_uc010gbu.2_Missense_Mutation_p.Q324H	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	324	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GTCCAGTTACCTGGAAAGCTA	0.428													0	0	0	0.00361	0	77	98										G	7866353	C	G	7866353	3	3	94	1	0	0	0	0	1	0	0	0	6951	695	24	4	152	4	HAO1	20	7866353	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2695910	7866353	55159167	319	28346										
PAK7	57144	broad.mit.edu	37	chr20	9561234	9561234	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	atttcaaaggcttcacctcaGaatagtaggcctccccgtgc	8	13	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:9561234G>C	uc002wnl.2	-	5	1093	c.548C>G	c.(547-549)TCT>TGT	p.S183C	PAK7_uc002wnk.2_Missense_Mutation_p.S183C|PAK7_uc002wnj.2_Missense_Mutation_p.S183C|PAK7_uc010gby.1_Missense_Mutation_p.S183C	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	183	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CTTCACCTCAGAATAGTAGGC	0.458													0	0	0	0.00361	0	70	102										C	9561234	G	C	9561234	3	2	94	1	0	0	0	0	1	0	0	0	11405	942	33	1	1639	1	PAK7	20	9561234	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1694881	9561234	53464286	320	28347										
FLRT3	23767	broad.mit.edu	37	chr20	14307438	14307438	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggaaggtttactggtgcagCagtcagggaattccgcacca	13	9	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:14307438C>T	uc002wov.1	-	3	1182	c.715G>A	c.(715-717)GCT>ACT	p.A239T	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.A239T	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	239	Extracellular (Potential).|LRR 8.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		ACTGGTGCAGCAGTCAGGGAA	0.438													0	0	0	0.007413	0	18	36										T	14307438	C	T	14307438	3	4	94	1	0	0	0	0	1	0	0	0	5940	710	25	2	1238	2	FLRT3	20	14307438	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	4746204	14307438	48718082	321	28348										
PLAGL2	5326	broad.mit.edu	37	chr20	30784504	30784504	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agaaagcccagtaggtgggaGaagtccacattagcagcgca	13	9	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:30784504G>T	uc002wxn.2	-	3	1459	c.1242C>A	c.(1240-1242)TTC>TTA	p.F414L		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	414						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTAGGTGGGAGAAGTCCACAT	0.642													1	0	0.000151284	0.001855	0.0002634	14	16										T	30784504	G	T	30784504	3	4	94	1	0	0	0	0	1	0	0	0	12020	933	33	3	252	3	PLAGL2	20	30784504	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	16477066	30784504	32241016	322	28349										
SAMHD1	25939	broad.mit.edu	37	chr20	35533895	35533896	+	Frame_Shift_Ins	INS	-	-	A													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtagagtataaaatctccagINSaaaaatgttatctgccaatt							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:35533895_35533896insA	uc002xgh.1	-	12	1411_1412	c.1281_1282insT	c.(1279-1284)TTTCTGfs	p.F427fs	SAMHD1_uc010gft.1_RNA	NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	427_428					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				AAAATCTCCAGAAAAATGTTAT	0.292																		41	63	---	---								A	35533896	-	A	35533895	7	5	94	1	0	1	1	0	0	0	0	0	13828	933	33	0	618	0	SAMHD1	20	35533895	Frame_Shift_Ins	INS	-	TCGA-G2-A2EJ-01A-11D-A17V-08	4749391	35533895	27491625	323	28350										
KCNQ2	3785	broad.mit.edu	37	chr20	62065242	62065242	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgcgagaggttggtggcgtaGaatctccaggccgactgcgg	17	10	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:62065242G>C	uc002yey.1	-	8	1215	c.1038C>G	c.(1036-1038)TTC>TTG	p.F346L	KCNQ2_uc002yez.1_Missense_Mutation_p.F346L|KCNQ2_uc002yfa.1_Missense_Mutation_p.F346L|KCNQ2_uc002yfb.1_Missense_Mutation_p.F346L|KCNQ2_uc011aax.1_Missense_Mutation_p.F346L|KCNQ2_uc002yfc.1_Missense_Mutation_p.F346L	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	346	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TGGTGGCGTAGAATCTCCAGG	0.692													0	0	0	0.006214	0	10	51										C	62065242	G	C	62065242	3	2	94	1	0	0	0	0	1	0	0	0	8083	933	33	1	1684	1	KCNQ2	20	62065242	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	26531347	62065242	960278	324	28351										
IFNAR1	3454	broad.mit.edu	37	chr21	34721714	34721714	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gctttcctacttcctccagtCtttaacattagatcccttag	4	13	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr21:34721714C>G	uc002yrn.2	+	8	1155	c.1008C>G	c.(1006-1008)GTC>GTG	p.V336V	IFNAR1_uc011adv.1_Silent_p.V267V	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	336	Fibronectin type-III 3.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TTCCTCCAGTCTTTAACATTA	0.343													0	0	0	0.000978	0	12	20										G	34721714	C	G	34721714	2	3	94	1	0	0	0	0	0	0	0	1	7544	900	32	1		1	IFNAR1	21	34721714	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08		34721714	13408181	325	28352										
ITSN1	6453	broad.mit.edu	37	chr21	35144562	35144562	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggaactggagaagcaactgGaaaagcagcgggagctagaa	15	6	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr21:35144562G>C	uc002yta.1	+	12	1508	c.1240G>C	c.(1240-1242)GAA>CAA	p.E414Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E414Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E377Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E414Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E377Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E298Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E414Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E377Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E414Q|ITSN1_uc002ytc.1_Missense_Mutation_p.E414Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E377Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E414Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E348Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	414	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						gaagcaactggaaaagcagcg	0.383													0	0	0	0.001168	0	6	1										C	35144562	G	C	35144562	3	2	94	1	0	0	0	0	1	0	0	0	7926	1175	41	1	1282	1	ITSN1	21	35144562	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	422848	35144562	12985333	326	28353										
PFKL	5211	broad.mit.edu	37	chr21	45726580	45726580	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	acaggcatgaacgctgctgtCcgggctgtgacgcgcatggg	16	11	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr21:45726580C>G	uc002zel.2	+	2	161	c.102C>G	c.(100-102)GTC>GTG	p.V34V	PFKL_uc002zek.2_Silent_p.V81V|PFKL_uc011afd.1_Silent_p.V81V	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	34					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		ACGCTGCTGTCCGGGCTGTGA	0.602													0	0	0	0.00308	0	7	8										G	45726580	C	G	45726580	2	3	94	1	0	0	0	0	0	0	0	1	11764	842	30	1		1	PFKL	21	45726580	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	10582018	45726580	2403315	327	28354										
GNB1L	54584	broad.mit.edu	37	chr22	19799811	19799811	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggcaggctggctctcacctcGtcgctgcccctccctggcac	11	19	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:19799811G>A	uc002zqe.1	-	4	808	c.414C>T	c.(412-414)GAC>GAT	p.D138D	GNB1L_uc002zqd.1_Translation_Start_Site|GNB1L_uc002zqf.1_Silent_p.D138D	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	138					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					CTCTCACCTCGTCGCTGCCCC	0.647													0	0	0	0.001368	0	10	15										A	19799811	G	A	19799811	2	1	94	1	0	0	0	0	0	0	0	1	6516	1136	40	2		2	GNB1L	22	19799811	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		19799811	31504755	328	28355										
PPM1F	9647	broad.mit.edu	37	chr22	22280017	22280017	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cacaaagccacccaatgcttCaatgcgcgccttctcatcct	5	17	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:22280017C>T	uc002zvp.1	-	7	1024	c.910G>A	c.(910-912)GAA>AAA	p.E304K	PPM1F_uc011aik.1_Missense_Mutation_p.E200K|PPM1F_uc002zvq.2_Missense_Mutation_p.E304K	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	304					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		CCCAATGCTTCAATGCGCGCC	0.622													0	0	0	0.00499	0	14	22										T	22280017	C	T	22280017	3	4	94	1	0	0	0	0	1	0	0	0	12339	835	29	1	462	1	PPM1F	22	22280017	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	2480206	22280017	29024549	329	28356										
GAS2L1	10634	broad.mit.edu	37	chr22	29708459	29708459	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gccctgcactcagtcaccccGagggctgagccagattcctg	11	16	2	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:29708459G>A	uc003afa.1	+	7	2218	c.2019G>A	c.(2017-2019)CCG>CCA	p.P673P	GAS2L1_uc010gvm.1_Silent_p.P446P|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Silent_p.P673P|GAS2L1_uc003afd.1_3'UTR|GAS2L1_uc003afe.1_3'UTR	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	673					cell cycle arrest	cytoplasm|cytoskeleton					0						CAGTCACCCCGAGGGCTGAGC	0.637													0	0	0	0.000602	0	5	18										A	29708459	G	A	29708459	2	1	94	1	0	0	0	0	0	0	0	1	6246	1058	37	1		1	GAS2L1	22	29708459	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7428442	29708459	21596107	330	28357										
EIF4ENIF1	56478	broad.mit.edu	37	chr22	31838041	31838041	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctgtaatgctgacagtttgGaatttgtagtgggagaagag	14	3	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:31838041G>T	uc003akz.1	-	17	2434	c.2270C>A	c.(2269-2271)TCC>TAC	p.S757Y	EIF4ENIF1_uc003akx.1_Missense_Mutation_p.S412Y|EIF4ENIF1_uc003aky.1_Missense_Mutation_p.S437Y|EIF4ENIF1_uc003ala.1_Missense_Mutation_p.S757Y|EIF4ENIF1_uc003alb.1_Missense_Mutation_p.S583Y|EIF4ENIF1_uc003akw.1_Missense_Mutation_p.S247Y	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	757						nucleus	protein binding|protein transporter activity			ovary(1)	1						TGACAGTTTGGAATTTGTAGT	0.468													1	0	5.48756e-27	0.002852	1.05298e-26	42	113										T	31838041	G	T	31838041	3	4	94	1	0	0	0	0	1	0	0	0	5035	1174	41	3	699	3	EIF4ENIF1	22	31838041	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2129582	31838041	19466525	331	28358										
FOXRED2	80020	broad.mit.edu	37	chr22	36892254	36892254	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtactcaaaggccgtggaatTcctgggagaacagcaacgcg	13	10	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:36892254T>G	uc003apn.3	-	6	1492	c.1384A>C	c.(1384-1386)AAT>CAT	p.N462H	FOXRED2_uc003apm.3_Missense_Mutation_p.N14H|FOXRED2_uc003apo.3_Missense_Mutation_p.N462H|FOXRED2_uc003app.3_Missense_Mutation_p.N462H	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	462					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GCCGTGGAATTCCTGGGAGAA	0.617													0	0	0	0.00245	0	14	49										G	36892254	T	G	36892254	3	3	94	1	0	0	0	0	1	0	0	0	6034	1797	62	5	682	5	FOXRED2	22	36892254	Missense_Mutation	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	5054213	36892254	14412312	332	28359										
EP300	2033	broad.mit.edu	37	chr22	41545045	41545045	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ttttttttttttttcagcctAtgggctatgggcctcgtatg	9	7	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:41545045A>G	uc003azl.3	+	13	2640	c.2245A>G	c.(2245-2247)ATG>GTG	p.M749V		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	749					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTTTCAGCCTATGGGCTATGG	0.393			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.003163	0	15	34										G	41545045	A	G	41545045	3	3	94	1	0	0	0	0	1	0	0	0	5148	449	16	5	2295	5	EP300	22	41545045	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	4652791	41545045	9759521	333	28360										
CCDC134	79879	broad.mit.edu	37	chr22	42209302	42209302	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gtggagaacacggccttcttCggcgatgtggtgctgcgctt	15	10	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:42209302C>T	uc003bbh.1	+	5	454	c.345C>T	c.(343-345)TTC>TTT	p.F115F	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|CCDC134_uc011apg.1_Intron	NM_024821	NP_079097	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134 precursor	115						extracellular region				ovary(2)	2						CGGCCTTCTTCGGCGATGTGG	0.592													0	0	0	0.002445	0	28	83										T	42209302	C	T	42209302	2	4	94	1	0	0	0	0	0	0	0	1	2768	883	31	1		1	CCDC134	22	42209302	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	664257	42209302	9095264	334	28361										
ARSD	414	broad.mit.edu	37	chrX	2836237	2836237	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggtggcagtgatccccgcgGgatgcacaattcacaccctg	12	13	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:2836237G>A	uc004cqy.2	-	5	547	c.471C>T	c.(469-471)TCC>TCT	p.S157S	ARSD_uc004cqz.1_Intron|ARSD_uc004cra.1_Silent_p.S157S	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	157						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GATCCCCGCGGGATGCACAAT	0.557													0	0	0	0.004672	0	3	6										A	2836237	G	A	2836237	2	1	94	1	0	0	0	0	0	0	0	1	989	1219	43	2		2	ARSD	23	2836237	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08		2836237	152434323	335	28362										
APOO	79135	broad.mit.edu	37	chrX	23898967	23898967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgaacaacatgttacctcatCaaccttcacggaatttttgg	6	10	3	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:23898967C>T	uc004dax.2	-	2	343	c.112G>A	c.(112-114)GAT>AAT	p.D38N	APOO_uc004daw.2_RNA|APOO_uc004day.3_RNA	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	apolipoprotein O precursor	38					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0						GTTACCTCATCAACCTTCACG	0.413													0	0	0	0.006214	0	10	35										T	23898967	C	T	23898967	3	4	94	1	0	0	0	0	1	0	0	0	813	826	29	1	512	1	APOO	23	23898967	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	21062730	23898967	131371593	336	28363										
DCAF8L2	347442	broad.mit.edu	37	chrX	27766328	27766328	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cgatggcacagagctgctagCcagctacaatgatgacgata	11	10	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:27766328C>G	uc011mjy.1	+	1	1403	c.1316C>G	c.(1315-1317)GCC>GGC	p.A439G		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						GAGCTGCTAGCCAGCTACAAT	0.443													0	0	0	0.001882	0	21	37										G	27766328	C	G	27766328	3	3	94	1	0	0	0	0	1	0	0	0	4278	739	26	4	1318	4	DCAF8L2	23	27766328	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3867361	27766328	127504232	337	28364										
FAM47A	158724	broad.mit.edu	37	chrX	34149301	34149301	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ccccgacgagtcttgggaggCgctaggcggagacgggacac	17	12	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:34149301C>T	uc004ddg.2	-	1	1128	c.1095G>A	c.(1093-1095)GCG>GCA	p.A365A		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	365										ovary(4)|central_nervous_system(1)	5						TCTTGGGAGGCGCTAGGCGGA	0.632													0	0	0	0.00245	0	15	26										T	34149301	C	T	34149301	2	4	94	1	0	0	0	0	0	0	0	1	5569	755	27	2		2	FAM47A	23	34149301	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	6382973	34149301	121121259	338	28365										
FAM47B	170062	broad.mit.edu	37	chrX	34962542	34962542	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taaaatactgggacaggagaCgccgggcggcaccgcattct	13	11	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:34962542C>T	uc004ddi.1	+	1	1612	c.1594C>T	c.(1594-1596)CGC>TGC	p.R532C		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	532										ovary(3)|breast(1)	4						GGACAGGAGACGCCGGGCGGC	0.498													0	0	0	0.002445	0	32	74										T	34962542	C	T	34962542	3	4	94	1	0	0	0	0	1	0	0	0	5570	536	19	2	1596	2	FAM47B	23	34962542	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	813241	34962542	120308018	339	28366										
CXorf22	170063	broad.mit.edu	37	chrX	35974113	35974113	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aagtggaattagcactgacaGgcacaggacttcctgtttta	10	8	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:35974113G>A	uc004ddj.2	+	8	1269	c.1210G>A	c.(1210-1212)GGC>AGC	p.G404S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	404										large_intestine(1)|lung(1)|ovary(1)	3						AGCACTGACAGGCACAGGACT	0.363													0	0	0	0.00333	0	21	69										A	35974113	G	A	35974113	3	1	94	1	0	0	0	0	1	0	0	0	4102	1000	35	2	1240	2	CXorf22	23	35974113	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	1011571	35974113	119296447	340	28367										
SHROOM4	57477	broad.mit.edu	37	chrX	50339780	50339780	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgatcttctcctccagctctCgctgttcaatgatgagagca	8	12	4	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:50339780C>G	uc004dpe.2	-	9	4423	c.4397G>C	c.(4396-4398)CGA>CCA	p.R1466P	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1466	Potential.|ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CTCCAGCTCTCGCTGTTCAAT	0.502													0	0	0	0.005443	0	26	33										G	50339780	C	G	50339780	3	3	94	1	0	0	0	0	1	0	0	0	14296	884	31	1	88	1	SHROOM4	23	50339780	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	14365667	50339780	104930780	341	28368										
SPANXN5	494197	broad.mit.edu	37	chrX	52825556	52825556	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggtcattctccagttgatttGaatgtattttcttagtcttc	7	7	4	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:52825556G>C	uc004drc.1	-	2	191	c.191C>G	c.(190-192)TCA>TGA	p.S64*		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	64											0	Ovarian(276;0.236)					CAGTTGATTTGAATGTATTTT	0.423													0	0	0	0.00623	0	37	95										C	52825556	G	C	52825556	4	2	94	1	0	0	0	0	0	1	0	0	14993	1294	45	1	31	1	SPANXN5	23	52825556	Nonsense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2485776	52825556	102445004	342	28369										
ITIH5L	347365	broad.mit.edu	37	chrX	54777522	54777522	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gttgcagggtactgggatgcCtgtagcggtgtcggaggact	18	7	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:54777522C>A	uc004dtj.2	-	12	3674	c.3644G>T	c.(3643-3645)AGG>ATG	p.R1215M		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1215					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						ACTGGGATGCCTGTAGCGGTG	0.627													1	0	3.59834e-05	0.001168	6.32513e-05	6	12										A	54777522	C	A	54777522	3	1	94	1	0	0	0	0	1	0	0	0	7908	681	24	4	305	4	ITIH5L	23	54777522	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	1951966	54777522	100493038	343	28370										
FAM123B	139285	broad.mit.edu	37	chrX	63412575	63412575	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggcctggctctgaccctctCaggccccttggcccctggct	11	18	2	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:63412575C>T	uc004dvo.2	-	2	865	c.592G>A	c.(592-594)GAG>AAG	p.E198K		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	198					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTGACCCTCTCAGGCCCCTTG	0.577													0	0	0	0.006122	0	18	71										T	63412575	C	T	63412575	3	4	94	1	0	0	0	0	1	0	0	0	5423	835	29	1	2819	1	FAM123B	23	63412575	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	8635053	63412575	91857985	344	28371										
MTMR8	55613	broad.mit.edu	37	chrX	63488786	63488786	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gatagggtgccattctccatCagggtattcaggtctccatt	10	10	4	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:63488786C>G	uc004dvs.2	-	14	1814	c.1746G>C	c.(1744-1746)CTG>CTC	p.L582L	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	582						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CATTCTCCATCAGGGTATTCA	0.483													0	0	0	0.00278	0	22	28										G	63488786	C	G	63488786	2	3	94	1	0	0	0	0	0	0	0	1	9949	813	29	1		1	MTMR8	23	63488786	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	76211	63488786	91781774	345	28372										
ZMYM3	9203	broad.mit.edu	37	chrX	70471043	70471043	+	Missense_Mutation	SNP	C	C	G													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cttactgctctcagtggaatCtacaacctcaggttttggag							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:70471043C>G	uc004dzh.1	-	4	850	c.763G>C	c.(763-765)GAT>CAT	p.D255H	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.D255H|ZMYM3_uc004dzj.1_Missense_Mutation_p.D255H|ZMYM3_uc011mpu.1_5'UTR|ZMYM3_uc004dzk.3_Missense_Mutation_p.D255H|ZMYM3_uc004dzl.3_Missense_Mutation_p.D255H|ZMYM3_uc004dzm.3_Missense_Mutation_p.D255H	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	255					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCAGTGGAATCTACAACCTCA	0.537													0	0	0	0.006122	0	14	61										G	70471043	C	G	70471043	3	3	94	1	0	0	0	0	1	0	0	0	17698	913	32	1	3455	1	ZMYM3	23	70471043	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	6982257	70471043	84799517	346	28373	141	2								
ZMYM3	9203	broad.mit.edu	37	chrX	70471052	70471052	+	Missense_Mutation	SNP	C	C	T													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctcagtggaatctacaacctCaggttttggaggttctgctc							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:70471052C>T	uc004dzh.1	-	4	841	c.754G>A	c.(754-756)GAG>AAG	p.E252K	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.E252K|ZMYM3_uc004dzj.1_Missense_Mutation_p.E252K|ZMYM3_uc011mpu.1_5'UTR|ZMYM3_uc004dzk.3_Missense_Mutation_p.E252K|ZMYM3_uc004dzl.3_Missense_Mutation_p.E252K|ZMYM3_uc004dzm.3_Missense_Mutation_p.E252K	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	252					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCTACAACCTCAGGTTTTGGA	0.532													0	0	0	0.008871	0	14	59										T	70471052	C	T	70471052	3	4	94	1	0	0	0	0	1	0	0	0	17698	835	29	1	3464	1	ZMYM3	23	70471052	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	9	70471052	84799508	347	28374	141	2								
OGT	8473	broad.mit.edu	37	chrX	70787373	70787373	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ctgaagcgtgttcccaatagTgtactctggctgttgcgttt	11	9	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:70787373T>C	uc004eaa.1	+	20	2830	c.2613T>C	c.(2611-2613)AGT>AGC	p.S871S	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.S861S|OGT_uc004eac.2_Silent_p.S732S|OGT_uc004ead.2_Silent_p.S490S	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	871					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TTCCCAATAGTGTACTCTGGC	0.398													0	0	0	0.001523	0	19	43										C	70787373	T	C	70787373	2	2	94	1	0	0	0	0	0	0	0	1	10847	1693	59	5		5	OGT	23	70787373	Silent	SNP	T	TCGA-G2-A2EJ-01A-11D-A17V-08	316321	70787373	84483187	348	28375										
P2RY10	27334	broad.mit.edu	37	chrX	78216602	78216602	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caaatgaatgcagttgcgttGgtcgggatgattacagttgc	13	6	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:78216602G>T	uc004ede.2	+	4	954	c.585G>T	c.(583-585)TTG>TTT	p.L195F	P2RY10_uc004edf.2_Missense_Mutation_p.L195F	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	195	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CAGTTGCGTTGGTCGGGATGA	0.458													1	0	1.64113e-05	0.001523	2.89868e-05	22	61										T	78216602	G	T	78216602	3	4	94	1	0	0	0	0	1	0	0	0	11347	1339	47	4	587	4	P2RY10	23	78216602	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7429229	78216602	77053958	349	28376										
CPXCR1	53336	broad.mit.edu	37	chrX	88008581	88008581	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	taaacagggagccaggcacaGcaacctcccaggaagatgtt	11	11	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:88008581G>T	uc004efd.3	+	3	425	c.166G>T	c.(166-168)GCA>TCA	p.A56S	CPXCR1_uc004efc.3_Missense_Mutation_p.A56S	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	56						intracellular	zinc ion binding			ovary(3)	3						GCCAGGCACAGCAACCTCCCA	0.453													1	0	8.12818e-05	0.001984	0.000142535	7	28										T	88008581	G	T	88008581	3	4	94	1	0	0	0	0	1	0	0	0	3836	971	34	4	168	4	CPXCR1	23	88008581	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	9791979	88008581	67261979	350	28377										
PCDH11X	27328	broad.mit.edu	37	chrX	91873589	91873589	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tagtgcaggctactgcacttCaccacagcccaccatcagca	7	16	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:91873589C>T	uc004efk.1	+	7	4539	c.3694C>T	c.(3694-3696)CAC>TAC	p.H1232Y	PCDH11X_uc004efl.1_Missense_Mutation_p.H1222Y|PCDH11X_uc004efo.1_Missense_Mutation_p.H1195Y|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.H1224Y|PCDH11X_uc004efn.1_Missense_Mutation_p.H1214Y	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1232	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TACTGCACTTCACCACAGCCC	0.587													0	0	0	0.00623	0	39	94										T	91873589	C	T	91873589	3	4	94	1	0	0	0	0	1	0	0	0	11508	826	29	1	3842	1	PCDH11X	23	91873589	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	3865008	91873589	63396971	351	28378										
PCDH19	57526	broad.mit.edu	37	chrX	99663576	99663576	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tggccagcagcagcagcaccGgcagcaggagcgactccatg	14	14	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:99663576G>A	uc010nmz.2	-	1	1696	c.20C>T	c.(19-21)CCG>CTG	p.P7L	PCDH19_uc004efw.3_Missense_Mutation_p.P7L|PCDH19_uc004efx.3_Missense_Mutation_p.P7L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	7					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CAGCAGCACCGGCAGCAGGAG	0.682													0	0	0	0.000248	0	3	5										A	99663576	G	A	99663576	3	1	94	1	0	0	0	0	1	0	0	0	11514	1116	39	2	3450	2	PCDH19	23	99663576	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	7789987	99663576	55606984	352	28379										
TCEAL2	140597	broad.mit.edu	37	chrX	101382355	101382355	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aggataaaaggagaaaaagcAaacagaaattgggggcgttt	13	3	0	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:101382355A>G	uc004eip.2	+	3	772	c.553A>G	c.(553-555)AAA>GAA	p.K185E		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GAGAAAAAGCAAACAGAAATT	0.453													0	0	0	0.00361	0	49	143										G	101382355	A	G	101382355	3	3	94	1	0	0	0	0	1	0	0	0	15668	131	5	5	555	5	TCEAL2	23	101382355	Missense_Mutation	SNP	A	TCGA-G2-A2EJ-01A-11D-A17V-08	1718779	101382355	53888205	353	28380										
IRS4	8471	broad.mit.edu	37	chrX	107975913	107975913	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tctccgggggtcttggcaccCggcgactgcgaggtggtggt	18	11	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:107975913C>T	uc004eoc.2	-	1	3695	c.3662G>A	c.(3661-3663)CGG>CAG	p.R1221Q		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	1221						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TCTTGGCACCCGGCGACTGCG	0.592													0	0	0	0.00361	0	75	185										T	107975913	C	T	107975913	3	4	94	1	0	0	0	0	1	0	0	0	7842	652	23	2	115	2	IRS4	23	107975913	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	6593558	107975913	47294647	354	28381										
NKAP	79576	broad.mit.edu	37	chrX	119077327	119077327	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	ggggcgcagagggccgctctCtagaacgcgaccgcgagcgt	17	13	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:119077327C>G	uc004esh.2	-	1	409	c.242G>C	c.(241-243)AGA>ACA	p.R81T		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	81	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						GGGCCGCTCTCTAGAACGCGA	0.662													0	0	0	0.004007	0	15	25										G	119077327	C	G	119077327	3	3	94	1	0	0	0	0	1	0	0	0	10439	913	32	1	1041	1	NKAP	23	119077327	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	11101414	119077327	36193233	355	28382										
GLUD2	2747	broad.mit.edu	37	chrX	120182413	120182413	+	Frame_Shift_Del	DEL	T	T	-													0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgaagcttcttacatgagcaTtttaggaatgacaccagggt							TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:120182413delT	uc004eto.2	+	1	952	c.875delT	c.(874-876)ATTfs	p.I292fs		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	292					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TACATGAGCATTTTAGGAATG	0.438																		36	108	---	---								-	120182413	T	-	120182413	7	5	94	1	0	1	0	1	0	0	0	0	6477	1493	52	0	877	0	GLUD2	23	120182413	Frame_Shift_Del	DEL	T	TCGA-G2-A2EJ-01A-11D-A17V-08	1105086	120182413	35088147	356	28383										
GLUD2	2747	broad.mit.edu	37	chrX	120182792	120182792	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gaagctgataagatcttcctGgagagaaacattttggttat	10	5	1	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:120182792G>T	uc004eto.2	+	1	1331	c.1254G>T	c.(1252-1254)CTG>CTT	p.L418L		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	418					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	AGATCTTCCTGGAGAGAAACA	0.438													1	0	7.89702e-26	0.00361	1.50743e-25	57	187										T	120182792	G	T	120182792	2	4	94	1	0	0	0	0	0	0	0	1	6477	1335	47	4		4	GLUD2	23	120182792	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	379	120182792	35087768	357	28384										
DCAF12L1	139170	broad.mit.edu	37	chrX	125685766	125685766	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	caaggacaccgctcccagttCctggttcttgccgccgcagg	11	16	1	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:125685766C>A	uc004eul.2	-	1	1077	c.826G>T	c.(826-828)GAA>TAA	p.E276*		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	276	WD 3.									skin(3)|ovary(1)	4						GCTCCCAGTTCCTGGTTCTTG	0.637													1	0	0.00010058	0.001368	0.000175955	11	30										A	125685766	C	A	125685766	4	1	94	1	0	0	0	0	0	1	0	0	4264	864	30	3	569	3	DCAF12L1	23	125685766	Nonsense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	5502974	125685766	29584794	358	28385										
BCORL1	63035	broad.mit.edu	37	chrX	129148662	129148662	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	aagcttccattgccgaaccaGcgcaagacaccccccatgcc	7	18	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:129148662G>A	uc004evb.1	+	4	2028	c.1914G>A	c.(1912-1914)CAG>CAA	p.Q638Q	BCORL1_uc010nrd.1_Silent_p.Q540Q	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	638	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGCCGAACCAGCGCAAGACAC	0.612													0	0	0	0.00632	0	28	65										A	129148662	G	A	129148662	2	1	94	1	0	0	0	0	0	0	0	1	1387	962	34	2		2	BCORL1	23	129148662	Silent	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	3462896	129148662	26121898	359	28386										
ZNF280C	55609	broad.mit.edu	37	chrX	129370577	129370577	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cactgtttactttagaagtaGaaggatgtttcaacacatat	7	6	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:129370577G>C	uc004evm.2	-	7	684	c.530C>G	c.(529-531)TCT>TGT	p.S177C	ZNF280C_uc010nrf.1_Missense_Mutation_p.S177C	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	177	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						TTTAGAAGTAGAAGGATGTTT	0.318													0	0	0	0.007413	0	19	52										C	129370577	G	C	129370577	3	2	94	1	0	0	0	0	1	0	0	0	17813	942	33	1	1735	1	ZNF280C	23	129370577	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	221915	129370577	25899983	360	28387										
BRS3	680	broad.mit.edu	37	chrX	135572431	135572431	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tttcaaatgtatacacttttCgagatcccaataaaaatatg	4	7	1	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:135572431C>G	uc004ezv.1	+	2	723	c.574C>G	c.(574-576)CGA>GGA	p.R192G		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	192	Extracellular (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ATACACTTTTCGAGATCCCAA	0.383													0	0	0	0.003755	0	37	54										G	135572431	C	G	135572431	3	3	94	1	0	0	0	0	1	0	0	0	1522	876	31	1	580	1	BRS3	23	135572431	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	6201854	135572431	19698129	361	28388										
GPR50	9248	broad.mit.edu	37	chrX	150349467	150349467	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tgttcatttcaagcctgcttCcagcaaccccaagcccatca	5	16	3	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:150349467C>G	uc010ntg.1	+	2	1547	c.1412C>G	c.(1411-1413)TCC>TGC	p.S471C		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	471	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCCTGCTTCCAGCAACCCC	0.552													0	0	0	0.00361	0	138	288										G	150349467	C	G	150349467	3	3	94	1	0	0	0	0	1	0	0	0	6697	855	30	1	1418	1	GPR50	23	150349467	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	14777036	150349467	4921093	362	28389										
GPR50	9248	broad.mit.edu	37	chrX	150349531	150349531	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agccactccaagtctgccttCagtgctgccaccagccaccc	7	19	2	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:150349531C>A	uc010ntg.1	+	2	1611	c.1476C>A	c.(1474-1476)TTC>TTA	p.F492L		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	492	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCTGCCTTCAGTGCTGCCA	0.572													1	0	4.92795e-40	0.00361	9.50575e-40	87	196										A	150349531	C	A	150349531	3	1	94	1	0	0	0	0	1	0	0	0	6697	825	29	3	1482	3	GPR50	23	150349531	Missense_Mutation	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	64	150349531	4921029	363	28390										
ATP2B3	492	broad.mit.edu	37	chrX	152818716	152818716	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	tcgtgggcattgaggaccctGtgcggcccgaggtagccacc	15	13	0	1			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:152818716G>T	uc004fht.1	+	11	2173	c.2047G>T	c.(2047-2049)GTG>TTG	p.V683L	ATP2B3_uc004fhs.1_Missense_Mutation_p.V683L	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	683	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGACCCTGTGCGGCCCGA	0.632													1	0	0.000219431	0.00245	0.000381145	13	27										T	152818716	G	T	152818716	3	4	94	1	0	0	0	0	1	0	0	0	1141	1377	48	4	2089	4	ATP2B3	23	152818716	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	2469185	152818716	2451844	364	28391										
SRPK3	26576	broad.mit.edu	37	chrX	153048313	153048313	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	agggcctgcccgtgccctgcGtgaagagcatcgtgaggcag	16	12	0	3			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:153048313G>A	uc004fil.2	+	6	594	c.562G>A	c.(562-564)GTG>ATG	p.V188M	SRPK3_uc004fik.2_Missense_Mutation_p.V254M|SRPK3_uc010nul.2_Missense_Mutation_p.V146M|SRPK3_uc004fin.2_Missense_Mutation_p.V188M|SRPK3_uc004fim.2_Missense_Mutation_p.V188M	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	188	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CGTGCCCTGCGTGAAGAGCAT	0.642													0	0	0	0.00245	0	14	20										A	153048313	G	A	153048313	3	1	94	1	0	0	0	0	1	0	0	0	15160	1145	40	2	584	2	SRPK3	23	153048313	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	229597	153048313	2222247	365	28392										
FLNA	2316	broad.mit.edu	37	chrX	153578566	153578566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	cccgagggatgaagcgcacaGcatacttatctgaggagcag	13	10	1	2			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:153578566G>A	uc004fkk.2	-	45	7415	c.7166C>T	c.(7165-7167)GCT>GTT	p.A2389V	FLNA_uc004fki.2_Missense_Mutation_p.A432V|FLNA_uc011mzn.1_Missense_Mutation_p.A522V|FLNA_uc010nuu.1_Missense_Mutation_p.A2381V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2389	Filamin 22.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GAAGCGCACAGCATACTTATC	0.582													0	0	0	0.003954	0	23	58										A	153578566	G	A	153578566	3	1	94	1	0	0	0	0	1	0	0	0	5933	971	34	2	793	2	FLNA	23	153578566	Missense_Mutation	SNP	G	TCGA-G2-A2EJ-01A-11D-A17V-08	530253	153578566	1691994	366	28393										
CTAG2	30848	broad.mit.edu	37	chrX	153880854	153880854	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.421917808219178	154	1.85371702945925e-50	3.70053834099985	4.84479880513091	2.83200328991242	0.0343795661843672	0.0931113250826612	112	gcggcatcccgggacaggatCctgcggaccagctccgcttc	13	16	0	0			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:153880854C>T	uc004fmi.1	-	2	374	c.321G>A	c.(319-321)AGG>AGA	p.R107R	CTAG2_uc004fmh.1_Silent_p.R107R	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	107						centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACAGGATCCTGCGGACCA	0.622													0	0	0	0.001523	0	18	35										T	153880854	C	T	153880854	2	4	94	1	0	0	0	0	0	0	0	1	3991	854	30	1		1	CTAG2	23	153880854	Silent	SNP	C	TCGA-G2-A2EJ-01A-11D-A17V-08	302288	153880854	1389706	367	28394										
PQLC2	54896	broad.mit.edu	37	chr1	19653755	19653755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	cacccaggggatctcctactCtctgttcgcgctggtgatgc	11	14	2	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:19653755C>G	uc001bby.2	+	8	1005	c.653C>G	c.(652-654)TCT>TGT	p.S218C	PQLC2_uc001bbz.2_Missense_Mutation_p.S153C|PQLC2_uc001bca.2_Missense_Mutation_p.S218C|PQLC2_uc001bcb.2_Missense_Mutation_p.S107C|PQLC2_uc001bcc.2_Missense_Mutation_p.S107C	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	218	PQ-loop 2.|Helical; (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTCCTACTCTCTGTTCGCG	0.527													0	0	0	0.080935	0	9	81										G	19653755	C	G	19653755	3	3	95	1	0	0	0	0	1	0	0	0	12419	913	32	1	675	1	PQLC2	1	19653755	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		19653755	229596866	1	28395										
ARID1A	8289	broad.mit.edu	37	chr1	27100151	27100152	+	Frame_Shift_Ins	INS	-	-	G													0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	atgccttccaacccagactcINSggggatgtattctcctagcc							TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:27100151_27100152insG	uc001bmv.1	+	16	4320_4321	c.3947_3948insG	c.(3946-3948)TCGfs	p.S1316fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.S1315fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.S1316fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.S933fs|ARID1A_uc001bmx.1_Frame_Shift_Ins_p.S162fs|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1316					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.M1318fs*163(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AACCCAGACTCGGGGATGTATT	0.51			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													28	79	---	---								G	27100152	-	G	27100151	7	5	95	1	0	1	1	0	0	0	0	0	913	893	31	0	4009	0	ARID1A	1	27100151	Frame_Shift_Ins	INS	-	TCGA-G2-A2EK-01A-22D-A18F-08	7446396	27100151	222150470	2	28396										
HDAC1	3065	broad.mit.edu	37	chr1	32797278	32797278	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tctctcccattggccacagaCagcgactgtttgagaacctt	8	13	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:32797278C>T	uc001bvb.1	+	11	1153	c.1090C>T	c.(1090-1092)CAG>TAG	p.Q364*	HDAC1_uc010ohf.1_Nonsense_Mutation_p.Q335*|HDAC1_uc001bvc.1_Nonsense_Mutation_p.Q120*	NM_004964	NP_004955	Q13547	HDAC1_HUMAN	histone deacetylase 1	364					anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)	3		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	TGGCCACAGACAGCGACTGTT	0.552													0	0	0	0.125774	0	26	89										T	32797278	C	T	32797278	4	4	95	1	0	0	0	0	0	1	0	0	7004	492	17	2	1132	2	HDAC1	1	32797278	Nonsense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	5697127	32797278	216453343	3	28397										
CYP4Z1	199974	broad.mit.edu	37	chr1	47583503	47583503	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	agtggcattaactctgctccGcttcaagctggctccagacc	9	14	2	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:47583503G>T	uc001cqu.1	+	12	1418	c.1415G>T	c.(1414-1416)CGC>CTC	p.R472L		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	472	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						ACTCTGCTCCGCTTCAAGCTG	0.468													1	0	9.7654e-05	0.043863	0.000105708	19	35										T	47583503	G	T	47583503	3	4	95	1	0	0	0	0	1	0	0	0	4194	1087	38	4	1461	4	CYP4Z1	1	47583503	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	14786225	47583503	201667118	4	28398										
SEC22B	9554	broad.mit.edu	37	chr1	145103956	145103956	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gtcaggctaagtaactctttCgaaagttgaatgaacagtcc	9	8	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:145103956C>T	uc001eml.1	+	4	264	c.124C>T	c.(124-126)CGA>TGA	p.R42*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	42	Longin.|Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						GTAACTCTTTCGAAAGTTGAA	0.388													0	0	0	0.014758	0	3	20										T	145103956	C	T	145103956	4	4	95	1	0	0	0	0	0	1	0	0	13989	876	31	1	130	1	SEC22B	1	145103956	Nonsense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	97520453	145103956	104146665	5	28399										
SNX27	81609	broad.mit.edu	37	chr1	151655862	151655862	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	atgtgaagaaaggttacatcAaagcagaagaaaagtcctat	9	5	1	4			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:151655862A>G	uc001eyn.1	+	8	1196	c.1180A>G	c.(1180-1182)AAA>GAA	p.K394E	SNX27_uc001eyo.2_Missense_Mutation_p.K301E|SNX27_uc001eyp.2_Missense_Mutation_p.K208E	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	394					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGTTACATCAAAGCAGAAGA	0.358													0	0	0	0.058154	0	8	23										G	151655862	A	G	151655862	3	3	95	1	0	0	0	0	1	0	0	0	14897	131	5	5	1210	5	SNX27	1	151655862	Missense_Mutation	SNP	A	TCGA-G2-A2EK-01A-22D-A18F-08	6551906	151655862	97594759	6	28400										
RGS5	8490	broad.mit.edu	37	chr1	163117208	163117208	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tttccatcagggcatggattCttttctgggccatgtcaaag	10	9	4	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:163117208C>G	uc001gcn.2	-	5	717	c.470G>C	c.(469-471)AGA>ACA	p.R157T	RGS5_uc009wvb.2_RNA	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	157	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			GGCATGGATTCTTTTCTGGGC	0.453													0	0	0	0.049695	0	20	46										G	163117208	C	G	163117208	3	3	95	1	0	0	0	0	1	0	0	0	13308	913	32	1	79	1	RGS5	1	163117208	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	11461346	163117208	86133413	7	28401										
HMCN1	83872	broad.mit.edu	37	chr1	186024541	186024541	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tcagttagaccaaccataacCaacagtggcagccaccctac	6	15	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:186024541C>T	uc001grq.1	+	45	7108	c.6879C>T	c.(6877-6879)ACC>ACT	p.T2293T		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2293	Ig-like C2-type 21.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CAACCATAACCAACAGTGGCA	0.443													0	0	0	0.062417	0	19	37										T	186024541	C	T	186024541	2	4	95	1	0	0	0	0	0	0	0	1	7220	581	21	2		2	HMCN1	1	186024541	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	22907333	186024541	63226080	8	28402										
SIPA1L2	57568	broad.mit.edu	37	chr1	232601037	232601037	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	acttttctgatttatgggctGcattttctgcattgattact	7	7	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:232601037G>A	uc001hvg.2	-	7	2527	c.2369C>T	c.(2368-2370)GCA>GTA	p.A790V	SIPA1L2_uc001hvf.2_5'Flank	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	790	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTTATGGGCTGCATTTTCTGC	0.488													0	0	0	0.014758	0	4	138										A	232601037	G	A	232601037	3	1	95	1	0	0	0	0	1	0	0	0	14330	1319	46	2	2859	2	SIPA1L2	1	232601037	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	46576496	232601037	16649584	9	28403										
LYST	1130	broad.mit.edu	37	chr1	235952067	235952067	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tcaacgctttggatcccagtGaaattatatgaatacatcct	6	9	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:235952067G>A	uc001hxj.2	-	13	4797	c.4622C>T	c.(4621-4623)TCA>TTA	p.S1541L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1541					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGATCCCAGTGAAATTATATG	0.408									Chediak-Higashi_syndrome				0	0	0	0.069234	0	11	20										A	235952067	G	A	235952067	3	1	95	1	0	0	0	0	1	0	0	0	9128	1294	45	1	6947	1	LYST	1	235952067	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	3351030	235952067	13298554	10	28404										
HEATR1	55127	broad.mit.edu	37	chr1	236716940	236716940	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gttcagtggtttccaaagagAgtcatccgccatggccaccg	11	12	2	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:236716940A>G	uc001hyd.1	-	43	6303	c.6178T>C	c.(6178-6180)TCT>CCT	p.S2060P	HEATR1_uc009xgh.1_Missense_Mutation_p.S1222P	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	2060					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTCCAAAGAGAGTCATCCGCC	0.493													0	0	0	0.050027	0	16	55										G	236716940	A	G	236716940	3	3	95	1	0	0	0	0	1	0	0	0	7027	304	11	5	268	5	HEATR1	1	236716940	Missense_Mutation	SNP	A	TCGA-G2-A2EK-01A-22D-A18F-08	764873	236716940	12533681	11	28405			1	126		2	2	25	A		6.357058e-05
HEATR1	55127	broad.mit.edu	37	chr1	236716964	236716964	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	atccgccatggccaccgaaaActgtgcgatgcatggtatca	10	12	1	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:236716964A>G	uc001hyd.1	-	43	6279	c.6154T>C	c.(6154-6156)TTT>CTT	p.F2052L	HEATR1_uc009xgh.1_Missense_Mutation_p.F1214L	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	2052					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GCCACCGAAAACTGTGCGATG	0.493													0	0	0	0.080422	0	19	58										G	236716964	A	G	236716964	3	3	95	1	0	0	0	0	1	0	0	0	7027	43	2	5	292	5	HEATR1	1	236716964	Missense_Mutation	SNP	A	TCGA-G2-A2EK-01A-22D-A18F-08	24	236716964	12533657	12	28406			1	126		2	2	25	A		6.357058e-05
OR2T33	391195	broad.mit.edu	37	chr1	248436878	248436878	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ttccggtcaagtagtcagccGccattttgggcacagtggtg	13	10	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:248436878G>A	uc010pzi.1	-	1	239	c.239C>T	c.(238-240)GCG>GTG	p.A80V		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTAGTCAGCCGCCATTTTGGG	0.567													0	0	0	0.139131	0	51	163										A	248436878	G	A	248436878	3	1	95	1	0	0	0	0	1	0	0	0	11024	1087	38	2	726	2	OR2T33	1	248436878	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	11719914	248436878	813743	13	28407										
POLR1A	25885	broad.mit.edu	37	chr2	86258591	86258591	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gtgggtttccggggctgcgtCaggagggcgggaagggacgg	23	7	1	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:86258591C>G	uc002sqs.2	-	30	4819	c.4440G>C	c.(4438-4440)CTG>CTC	p.L1480L	POLR1A_uc010ytb.1_Silent_p.L846L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1480					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGGGCTGCGTCAGGAGGGCGG	0.632													0	0	0	0.086207	0	36	111										G	86258591	C	G	86258591	2	3	95	1	0	0	0	0	0	0	0	1	12209	813	29	1		1	POLR1A	2	86258591	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		86258591	156940782	14	28408			2	127		3	3	153	C		8.049925e-08
POLR1A	25885	broad.mit.edu	37	chr2	86258707	86258707	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ttcctcctgcatgtcttcatCgtcgttctcctcgccctccc	5	19	3	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:86258707C>T	uc002sqs.2	-	30	4703	c.4324G>A	c.(4324-4326)GAT>AAT	p.D1442N	POLR1A_uc010ytb.1_Missense_Mutation_p.D808N	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1442					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						atgtcttcatcgtcgttctcc	0.393													0	0	0	0.038395	0	17	53										T	86258707	C	T	86258707	3	4	95	1	0	0	0	0	1	0	0	0	12209	884	31	1	858	1	POLR1A	2	86258707	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	116	86258707	156940666	15	28409			2	127		3	3	153	C		8.049925e-08
POLR1A	25885	broad.mit.edu	37	chr2	86258743	86258743	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ctccctctcctcctcttcctCactctcataatcaacctggc	2	20	5	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:86258743C>A	uc002sqs.2	-	30	4667	c.4288G>T	c.(4288-4290)GAG>TAG	p.E1430*	POLR1A_uc010ytb.1_Nonsense_Mutation_p.E796*	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1430					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						tcctcttcctcACTCTCATAA	0.383													1	0	1.67942e-08	0.038395	1.8562e-08	18	56										A	86258743	C	A	86258743	4	1	95	1	0	0	0	0	0	1	0	0	12209	835	29	3	894	3	POLR1A	2	86258743	Nonsense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	36	86258743	156940630	16	28410			2	127		3	3	153	C		8.049925e-08
FGD5	152273	broad.mit.edu	37	chr3	14862507	14862507	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ctgatcgagagcgactccccGgacaagtacaagaagaagaa	11	10	0	5			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:14862507G>A	uc003bzc.2	+	1	2039	c.1929G>A	c.(1927-1929)CCG>CCA	p.P643P	FGD5_uc011avk.1_Silent_p.P643P	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	643					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GCGACTCCCCGGACAAGTACA	0.507													0	0	0	0.062417	0	21	45										A	14862507	G	A	14862507	2	1	95	1	0	0	0	0	0	0	0	1	5836	1103	39	2		2	FGD5	3	14862507	Silent	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		14862507	183159923	17	28411										
RHOA	387	broad.mit.edu	37	chr3	49397710	49397710	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	agcagctctcgtagccatttCaaaaacctctctcactccat	4	15	4	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:49397710C>T	uc003cwu.2	-	5	790	c.514G>A	c.(514-516)GAA>AAA	p.E172K	RHOA_uc010hku.2_Missense_Mutation_p.E91K|GPX1_uc011bcl.1_5'Flank|GPX1_uc011bcm.1_5'Flank	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	172					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GTAGCCATTTCAAAAACCTCT	0.483													0	0	0	0.055883	0	20	91										T	49397710	C	T	49397710	3	4	95	1	0	0	0	0	1	0	0	0	13331	835	29	1	71	1	RHOA	3	49397710	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	34535203	49397710	148624720	18	28412										
ADPRH	141	broad.mit.edu	37	chr3	119305346	119305346	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	cacccaacaggctacctgggGgcccttgcgtctgctctttt	10	15	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:119305346G>A	uc003ecs.2	+	4	811	c.513G>A	c.(511-513)GGG>GGA	p.G171G	ADPRH_uc010hqv.2_Silent_p.G171G|ADPRH_uc011bjb.1_Silent_p.G64G|ADPRH_uc003ect.2_Silent_p.G171G	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	171					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		GCTACCTGGGGGCCCTTGCGT	0.542													0	0	0	0.069456	0	38	115										A	119305346	G	A	119305346	2	1	95	1	0	0	0	0	0	0	0	1	331	1219	43	2		2	ADPRH	3	119305346	Silent	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	69907636	119305346	78717084	19	28413										
PLSCR1	5359	broad.mit.edu	37	chr3	146251317	146251317	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tggcaagtttgtttccgggtGagaagcattcatctgtgagt	13	6	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:146251317G>T	uc003evx.3	-	3	422	c.34C>A	c.(34-36)CAC>AAC	p.H12N	PLSCR1_uc003evy.3_Missense_Mutation_p.H5N|PLSCR1_uc011bnn.1_Silent_p.L3L|PLSCR1_uc003evz.3_RNA|PLSCR1_uc003ewa.2_Missense_Mutation_p.H12N	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	12	Cytoplasmic.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						GTTTCCGGGTGAGAAGCATTC	0.348													1	0	3.62473e-10	0.062417	4.0489e-10	22	82										T	146251317	G	T	146251317	3	4	95	1	0	0	0	0	1	0	0	0	12109	1290	45	3	950	3	PLSCR1	3	146251317	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	26945971	146251317	51771113	20	28414										
BOD1L	259282	broad.mit.edu	37	chr4	13601146	13601146	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	caacaatacattcttctcttCtgcatttatgaggtgtaaag	6	8	3	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:13601146C>A	uc003gmz.1	-	10	7495	c.7378G>T	c.(7378-7380)GAA>TAA	p.E2460*	BOD1L_uc010idr.1_Nonsense_Mutation_p.E1797*	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2460							DNA binding			ovary(5)|breast(1)	6						TTCTTCTCTTCTGCATTTATG	0.468											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.39187e-15	0.049695	2.7005e-15	19	60										A	13601146	C	A	13601146	4	1	95	1	0	0	0	0	0	1	0	0	1483	922	32	3	1845	3	BOD1L	4	13601146	Nonsense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		13601146	177553130	21	28415										
BOD1L	259282	broad.mit.edu	37	chr4	13601587	13601587	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tgtgatggtgagccgatcttCatcctggaggacagcaccaa	12	10	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:13601587C>T	uc003gmz.1	-	10	7054	c.6937G>A	c.(6937-6939)GAA>AAA	p.E2313K	BOD1L_uc010idr.1_Missense_Mutation_p.E1650K	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2313							DNA binding			ovary(5)|breast(1)	6						AGCCGATCTTCATCCTGGAGG	0.522													0	0	0	0.058154	0	10	6										T	13601587	C	T	13601587	3	4	95	1	0	0	0	0	1	0	0	0	1483	835	29	1	2286	1	BOD1L	4	13601587	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	441	13601587	177552689	22	28416										
PCDH18	54510	broad.mit.edu	37	chr4	138451062	138451062	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	taggatctagtgtctttcttCtcgcggttacacctagttgc	9	10	4	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:138451062C>G	uc003ihe.3	-	1	2568	c.2181G>C	c.(2179-2181)GAG>GAC	p.E727D	PCDH18_uc003ihf.3_Missense_Mutation_p.E720D|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E507D|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	727	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TGTCTTTCTTCTCGCGGTTAC	0.448													0	0	0	0.069288	0	23	43										G	138451062	C	G	138451062	3	3	95	1	0	0	0	0	1	0	0	0	11513	912	32	1	1242	1	PCDH18	4	138451062	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	124849475	138451062	52703214	23	28417										
SLC6A19	340024	broad.mit.edu	37	chr5	1214154	1214154	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ctggccttcgggggcctcatCtccttctccagctacaactc	8	17	3	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:1214154C>G	uc003jbw.3	+	6	917	c.861C>G	c.(859-861)ATC>ATG	p.I287M		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	287	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGGGCCTCATCTCCTTCTCCA	0.622													0	0	0	0.0918	0	24	85										G	1214154	C	G	1214154	3	3	95	1	0	0	0	0	1	0	0	0	14682	903	32	1	883	1	SLC6A19	5	1214154	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		1214154	179701106	24	28418										
IL6ST	3572	broad.mit.edu	37	chr5	55252048	55252048	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	caagatttttccattggcttCaaaaggaggcaatgtctgta	9	7	2	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:55252048C>G	uc003jqq.2	-	10	1327	c.1072G>C	c.(1072-1074)GAA>CAA	p.E358Q	IL6ST_uc010iwb.2_Missense_Mutation_p.E358Q|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.E69Q|IL6ST_uc003jqr.2_Nonstop_Mutation_p.*330S	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	358	Extracellular (Potential).|Fibronectin type-III 3.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				CCATTGGCTTCAAAAGGAGGC	0.279			O		hepatocellular ca								0	0	0	0.02938	0	7	35										G	55252048	C	G	55252048	3	3	95	1	0	0	0	0	1	0	0	0	7703	838	29	1	1716	1	IL6ST	5	55252048	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	54037894	55252048	125663212	25	28419										
PCDHA4	56144	broad.mit.edu	37	chr5	140188974	140188974	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	accgagggcgcgtgcgctccGggcaagcccacgctggtgtg	17	14	0	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140188974G>A	uc003lhi.2	+	1	2303	c.2202G>A	c.(2200-2202)CCG>CCA	p.P734P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.P734P|PCDHA4_uc011daa.1_Silent_p.P734P	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	734	Cytoplasmic (Potential).|PXXP 1.|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCGCTCCGGGCAAGCCCA	0.682													0	0	0	0.055883	0	22	50										A	140188974	G	A	140188974	2	1	95	1	0	0	0	0	0	0	0	1	11526	1103	39	2		2	PCDHA4	5	140188974	Silent	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	84936926	140188974	40726286	26	28420										
PCDHA9	9752	broad.mit.edu	37	chr5	140229486	140229486	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gttcgtgaaggagaacaaccCgccgggctgccacatcttca	11	13	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140229486C>T	uc003lhu.2	+	1	2130	c.1406C>T	c.(1405-1407)CCG>CTG	p.P469L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.P469L	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	469	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAACAACCCGCCGGGCTGC	0.672													0	0	0	0.09836	0	41	87										T	140229486	C	T	140229486	3	4	95	1	0	0	0	0	1	0	0	0	11531	652	23	2	1408	2	PCDHA9	5	140229486	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	40512	140229486	40685774	27	28421										
PCDHB2	56133	broad.mit.edu	37	chr5	140476332	140476332	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	caaggacaatggcgagcctcCgcgctcggccaccgccacgc	12	18	0	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140476332C>T	uc003lil.2	+	1	2096	c.1958C>T	c.(1957-1959)CCG>CTG	p.P653L	PCDHB2_uc003lim.1_Missense_Mutation_p.P314L	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	653	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGAGCCTCCGCGCTCGGCC	0.721													0	0	0	0.0918	0	24	68										T	140476332	C	T	140476332	3	4	95	1	0	0	0	0	1	0	0	0	11542	652	23	2	1960	2	PCDHB2	5	140476332	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	246846	140476332	40438928	28	28422										
PCDHB4	56131	broad.mit.edu	37	chr5	140503159	140503159	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	acgaggccctgcaggcgttcGagttccgcgtgggcgcctca	15	14	1	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140503159G>A	uc003lip.1	+	1	1579	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	527	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGCGTTCGAGTTCCGCGT	0.677													0	0	0	0.092188	0	42	85										A	140503159	G	A	140503159	3	1	95	1	0	0	0	0	1	0	0	0	11544	1059	37	1	1581	1	PCDHB4	5	140503159	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	26827	140503159	40412101	29	28423										
PCDHB15	56121	broad.mit.edu	37	chr5	140626734	140626734	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ccctgcaggctttcgagttcCgcgtgggcgccacagaccgc	13	16	0	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140626734C>T	uc003lje.2	+	1	1588	c.1588C>T	c.(1588-1590)CGC>TGC	p.R530C		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	530	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCGAGTTCCGCGTGGGCGC	0.662													0	0	0	0.045705	0	33	78										T	140626734	C	T	140626734	3	4	95	1	0	0	0	0	1	0	0	0	11540	652	23	2	1590	2	PCDHB15	5	140626734	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	123575	140626734	40288526	30	28424										
HIST1H1D	3007	broad.mit.edu	37	chr6	26234607	26234607	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ttagctggactcttggcagcTttttttggctgaggtgtttt	12	6	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:26234607T>C	uc003nhd.2	-	1	610	c.555A>G	c.(553-555)AAA>AAG	p.K185K		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	185					nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TCTTGGCAGCTTTTTTTGGCT	0.522													0	0	0	0.009096	0	3	131										C	26234607	T	C	26234607	2	2	95	1	0	0	0	0	0	0	0	1	7125	1606	56	5		5	HIST1H1D	6	26234607	Silent	SNP	T	TCGA-G2-A2EK-01A-22D-A18F-08		26234607	144880460	31	28425										
VARS	7407	broad.mit.edu	37	chr6	31760629	31760629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ggacacacgtgacaaaccagCgagtcacattattccagatc	8	12	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:31760629C>T	uc003nxe.2	-	4	989	c.566G>A	c.(565-567)CGC>CAC	p.R189H	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	189	GST C-terminal.				translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GACAAACCAGCGAGTCACATT	0.547													0	0	0	0.080935	0	12	46										T	31760629	C	T	31760629	3	4	95	1	0	0	0	0	1	0	0	0	17120	768	27	2	3336	2	VARS	6	31760629	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	5526022	31760629	139354438	32	28426										
GPR110	266977	broad.mit.edu	37	chr6	46969267	46969267	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gcagtgggttgaaaggctttGagaatttgggtttggcagat	16	3	0	3			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:46969267G>A	uc003oyt.2	-	14	2829	c.2630C>T	c.(2629-2631)TCA>TTA	p.S877L	GPR110_uc011dwl.1_Missense_Mutation_p.S565L	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	877	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						GAAAGGCTTTGAGAATTTGGG	0.313													0	0	0	0.080935	0	9	18										A	46969267	G	A	46969267	3	1	95	1	0	0	0	0	1	0	0	0	6627	1294	45	1	110	1	GPR110	6	46969267	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	15208638	46969267	124145800	33	28427										
CD164	8763	broad.mit.edu	37	chr6	109691643	109691643	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	taactgtcttggaagttgtaGaaggggagggctgaactgtg	16	4	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:109691643G>C	uc003pte.2	-	5	579	c.398C>G	c.(397-399)TCT>TGT	p.S133C	CD164_uc003ptd.2_Missense_Mutation_p.S133C|CD164_uc003ptf.2_Intron|CD164_uc011eap.1_Missense_Mutation_p.S133C|CD164_uc010kdn.2_Missense_Mutation_p.S120C	NM_006016	NP_006007	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin isoform 1	133	Thr-rich.|Extracellular (Potential).				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding				0		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		GGAAGTTGTAGAAGGGGAGGG	0.378													0	0	0	0.014758	0	4	21										C	109691643	G	C	109691643	3	2	95	1	0	0	0	0	1	0	0	0	2969	942	33	1	254	1	CD164	6	109691643	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	62722376	109691643	61423424	34	28428										
TNFAIP3	7128	broad.mit.edu	37	chr6	138198247	138198247	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ccacttgttaacagagaccgGggaagatttgaagacttaaa	10	7	0	4			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:138198247G>A	uc003qhr.2	+	6	906	c.840G>A	c.(838-840)CGG>CGA	p.R280R	TNFAIP3_uc003qhs.2_Silent_p.R280R	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	280	TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		ACAGAGACCGGGGAAGATTTG	0.358			D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								0	0	0	0.146539	0	13	47										A	138198247	G	A	138198247	2	1	95	1	0	0	0	0	0	0	0	1	16271	1219	43	2		2	TNFAIP3	6	138198247	Silent	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	28506604	138198247	32916820	35	28429										
KLHL7	55975	broad.mit.edu	37	chr7	23164704	23164704	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	acaatgttcagtctttgctgGatgcagcaaaccaatatcag	8	9	3	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:23164704G>A	uc003svs.3	+	4	648	c.355G>A	c.(355-357)GAT>AAT	p.D119N	KLHL7_uc003svr.3_Missense_Mutation_p.D97N|KLHL7_uc011jys.1_Missense_Mutation_p.D43N|KLHL7_uc011jyt.1_Intron|KLHL7_uc003svt.2_Missense_Mutation_p.D71N|KLHL7_uc003svp.2_Missense_Mutation_p.D97N|KLHL7_uc003svq.2_Missense_Mutation_p.D119N|KLHL7_uc011jyu.1_Missense_Mutation_p.D97N	NM_001031710	NP_001026880	Q8IXQ5	KLHL7_HUMAN	kelch-like 7 isoform 1	119						Golgi apparatus|nucleolus|plasma membrane					0						GTCTTTGCTGGATGCAGCAAA	0.318													0	0	0	0.146539	0	16	28										A	23164704	G	A	23164704	3	1	95	1	0	0	0	0	1	0	0	0	8394	1174	41	1	369	1	KLHL7	7	23164704	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		23164704	135973959	36	28430										
SEMA3D	223117	broad.mit.edu	37	chr7	84751133	84751133	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	agaaacaacatggtcatgctTagcatcatcaaagcaggaaa	8	8	3	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:84751133T>C	uc003uic.2	-	1	115	c.75A>G	c.(73-75)CTA>CTG	p.L25L	SEMA3D_uc010led.2_Silent_p.L25L|SEMA3D_uc010lee.1_Silent_p.L25L	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	25					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TGGTCATGCTTAGCATCATCA	0.333													0	0	0	0.049695	0	19	31										C	84751133	T	C	84751133	2	2	95	1	0	0	0	0	0	0	0	1	14027	1741	61	5		5	SEMA3D	7	84751133	Silent	SNP	T	TCGA-G2-A2EK-01A-22D-A18F-08	61586429	84751133	74387530	37	28431										
NAPEPLD	222236	broad.mit.edu	37	chr7	102760122	102760123	+	Frame_Shift_Ins	INS	-	-	A													0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	aataaccagtatctcctgcgINSaaaaaaaatcgattccaagg					rs147416689	by1000genomes	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:102760122_102760123insA	uc003vbc.2	-	3	1170_1171	c.842_843insT	c.(841-843)TTCfs	p.F281fs	NAPEPLD_uc003vbd.2_Frame_Shift_Ins_p.F281fs|NAPEPLD_uc011klj.1_Frame_Shift_Ins_p.F354fs|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	281				Missing (in Ref. 3; CAI56779).	phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						TATCTCCTGCGAAAAAAAATCG	0.46																		17	56	---	---								A	102760123	-	A	102760122	7	5	95	1	0	1	1	0	0	0	0	0	10163	1049	37	0	350	0	NAPEPLD	7	102760122	Frame_Shift_Ins	INS	-	TCGA-G2-A2EK-01A-22D-A18F-08	18008989	102760122	56378541	38	28432										
SVOPL	136306	broad.mit.edu	37	chr7	138310792	138310792	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	aagaggaagccaatcaggccGgcactagaaaacaggaagcg	13	9	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:138310792G>A	uc011kqh.1	-	12	1185	c.1185C>T	c.(1183-1185)GCC>GCT	p.A395A	SVOPL_uc003vue.2_Silent_p.A243A	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	395	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0						CAATCAGGCCGGCACTAGAAA	0.502													0	0	0	0.115264	0	3	38										A	138310792	G	A	138310792	2	1	95	1	0	0	0	0	0	0	0	1	15421	1103	39	2		2	SVOPL	7	138310792	Silent	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	35550670	138310792	20827871	39	28433										
CDKN2B	1030	broad.mit.edu	37	chr9	22006036	22006036	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tgcaacgtcgcggtggccccGctcctcggccaagtccacgg	13	17	0	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:22006036G>A	uc003zpo.2	-	2	727	c.367C>T	c.(367-369)CGG>TGG	p.R123W	MTAP_uc003zpi.1_Intron|CDKN2BAS_uc010miw.1_Intron|CDKN2BAS_uc010mix.1_Intron|CDKN2BAS_uc003zpm.2_Intron|CDKN2B_uc003zpn.2_3'UTR	NM_004936	NP_004927	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B isoform 1	123	ANK 4.				cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CGGTGGCCCCGCTCCTCGGCC	0.682									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				0	0	0	0.038147	0	6	14										A	22006036	G	A	22006036	3	1	95	1	0	0	0	0	1	0	0	0	3164	1086	38	2	53	2	CDKN2B	9	22006036	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		22006036	119207395	40	28434										
PTPN3	5774	broad.mit.edu	37	chr9	112145729	112145729	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gtttgtgaccagcatttctcGggacacataggcgatggtgc	13	9	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:112145729G>A	uc004bed.2	-	23	2468	c.2356C>T	c.(2356-2358)CGA>TGA	p.R786*	PTPN3_uc004beb.2_Nonsense_Mutation_p.R655*|PTPN3_uc004bec.2_Nonsense_Mutation_p.R610*|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Nonsense_Mutation_p.R741*|PTPN3_uc011lwh.1_Nonsense_Mutation_p.R632*|PTPN3_uc011lwd.1_Nonsense_Mutation_p.R254*|PTPN3_uc011lwe.1_Nonsense_Mutation_p.R499*|PTPN3_uc011lwf.1_Nonsense_Mutation_p.R454*	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	786	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AGCATTTCTCGGGACACATAG	0.602													0	0	0	0.117977	0	45	73										A	112145729	G	A	112145729	4	1	95	1	0	0	0	0	0	1	0	0	12789	1124	39	2	401	2	PTPN3	9	112145729	Nonsense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	90139693	112145729	29067702	41	28435										
TTF1	7270	broad.mit.edu	37	chr9	135263551	135263551	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	aataaggctgaccttggcccGcagggcattcatgccatagt	11	11	1	1	rs112758716		TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:135263551G>A	uc004cbl.2	-	8	2339	c.2287C>T	c.(2287-2289)CGG>TGG	p.R763W	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.R248W	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	763					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ACCTTGGCCCGCAGGGCATTC	0.363													0	0	0	0.115264	0	3	38										A	135263551	G	A	135263551	3	1	95	1	0	0	0	0	1	0	0	0	16715	1086	38	2	446	2	TTF1	9	135263551	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	23117822	135263551	5949880	42	28436										
GFI1B	8328	broad.mit.edu	37	chr9	135866388	135866388	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gtgcaccaaaggcttccagcGcaaggtggacctgcggcggc	15	13	0	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:135866388G>A	uc004ccg.2	+	7	1095	c.944G>A	c.(943-945)CGC>CAC	p.R315H	GFI1B_uc010mzy.2_Missense_Mutation_p.R269H	NM_004188	NP_004179	Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription	315	C2H2-type 6.|Mediates interaction with GATA1.|Interaction with ARIH2.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		GGCTTCCAGCGCAAGGTGGAC	0.647													0	0	0	0.009096	0	3	53										A	135866388	G	A	135866388	3	1	95	1	0	0	0	0	1	0	0	0	6340	1087	38	2	966	2	GFI1B	9	135866388	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	602837	135866388	5347043	43	28437										
CACNA1B	774	broad.mit.edu	37	chr9	140811877	140811877	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gagggctggactgacatcctCtataatgtgagtggcgtctt	13	8	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:140811877C>G	uc004cog.2	+	6	1105	c.960C>G	c.(958-960)CTC>CTG	p.L320L		NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	320	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTGACATCCTCTATAATGTGA	0.582													0	0	0	0.144211	0	27	41										G	140811877	C	G	140811877	2	3	95	1	0	0	0	0	0	0	0	1	2539	900	32	1		1	CACNA1B	9	140811877	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	4945489	140811877	401554	44	28438										
RPP38	10557	broad.mit.edu	37	chr10	15145354	15145354	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	accggggcggggatctctccGtaagacgagacctctggttg	15	11	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:15145354G>A	uc001iny.3	+	3	754	c.41G>A	c.(40-42)CGT>CAT	p.R14H	RPP38_uc009xjm.2_Missense_Mutation_p.R14H|RPP38_uc001inx.3_Missense_Mutation_p.R14H	NM_183005	NP_892117	P78345	RPP38_HUMAN	ribonuclease P/MRP 38 subunit	14					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			ovary(1)	1						GGATCTCTCCGTAAGACGAGA	0.498													0	0	0	0.099896	0	26	70										A	15145354	G	A	15145354	3	1	95	1	0	0	0	0	1	0	0	0	13613	1145	40	2	43	2	RPP38	10	15145354	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		15145354	120389393	45	28439										
NPFFR1	64106	broad.mit.edu	37	chr10	72026088	72026088	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gtttgtagccggggtggcctCagtgttagtcccattctgac	13	10	2	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:72026088C>T	uc010qjk.1	-	1	67	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_022146	NP_071429	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1	23	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide receptor activity				0						GGGGTGGCCTCAGTGTTAGTC	0.557													0	0	0	0.014758	0	5	27										T	72026088	C	T	72026088	3	4	95	1	0	0	0	0	1	0	0	0	10577	835	29	1	1236	1	NPFFR1	10	72026088	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	56880734	72026088	63508659	46	28440										
DNTT	1791	broad.mit.edu	37	chr10	98078110	98078110	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tctgtcttgcattttgcagtGattctgtcacccacatcgta	7	11	4	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:98078110G>A	uc001kmf.2	+	2	375	c.205G>A	c.(205-207)GAT>AAT	p.D69N	DNTT_uc001kmg.2_Missense_Mutation_p.D69N	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	69	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		ATTTTGCAGTGATTCTGTCAC	0.458													0	0	0	0.139131	0	55	83										A	98078110	G	A	98078110	3	1	95	1	0	0	0	0	1	0	0	0	4680	1304	45	1	211	1	DNTT	10	98078110	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	26052022	98078110	37456637	47	28441										
SORCS1	114815	broad.mit.edu	37	chr10	108380301	108380301	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tgacaaagggaagagacaggTgcacgtgctccaagggacct	14	9	0	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:108380301T>C	uc001kym.2	-	20	2689	c.2681A>G	c.(2680-2682)CAC>CGC	p.H894R	SORCS1_uc001kyl.2_Missense_Mutation_p.H894R|SORCS1_uc009xxs.2_Missense_Mutation_p.H894R|SORCS1_uc001kyn.1_Missense_Mutation_p.H894R|SORCS1_uc001kyo.2_Missense_Mutation_p.H894R	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	894	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAGAGACAGGTGCACGTGCTC	0.557													0	0	0	0.0333	0	17	30										C	108380301	T	C	108380301	3	2	95	1	0	0	0	0	1	0	0	0	14930	1696	59	5	1087	5	SORCS1	10	108380301	Missense_Mutation	SNP	T	TCGA-G2-A2EK-01A-22D-A18F-08	10302191	108380301	27154446	48	28442										
INPP5A	3632	broad.mit.edu	37	chr10	134563026	134563026	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gctgtctttctgcagacgctCtgcacaaaagccaccatgca	8	14	3	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:134563026C>G	uc001llp.2	+	10	986	c.738C>G	c.(736-738)CTC>CTG	p.L246L	INPP5A_uc001llo.1_Silent_p.L246L|INPP5A_uc001llq.2_Intron	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	246					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TGCAGACGCTCTGCACAAAAG	0.612													0	0	0	0.099896	0	23	47										G	134563026	C	G	134563026	2	3	95	1	0	0	0	0	0	0	0	1	7754	900	32	1		1	INPP5A	10	134563026	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	26182725	134563026	971721	49	28443										
QSER1	79832	broad.mit.edu	37	chr11	32994985	32994985	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	aactaacaataattactcgaGattctaaagcaaagagtgga	7	6	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr11:32994985G>A	uc001mty.2	+	11	5128	c.4861G>A	c.(4861-4863)GAT>AAT	p.D1621N	QSER1_uc001mtz.1_Missense_Mutation_p.D1382N|QSER1_uc001mua.2_Missense_Mutation_p.D1126N	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1621										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					AATTACTCGAGATTCTAAAGC	0.333													0	0	0	0.069288	0	23	30										A	32994985	G	A	32994985	3	1	95	1	0	0	0	0	1	0	0	0	12882	942	33	1	4895	1	QSER1	11	32994985	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		32994985	102011531	50	28444										
TYR	7299	broad.mit.edu	37	chr11	88911384	88911384	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ttccgtcttttataataggaCctgccagtgctctggcaact	8	11	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr11:88911384C>T	uc001pcs.2	+	1	345	c.263C>T	c.(262-264)ACC>ATC	p.T88I		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	88	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TATAATAGGACCTGCCAGTGC	0.502									Oculocutaneous_Albinism				0	0	0	0.047766	0	9	36										T	88911384	C	T	88911384	3	4	95	1	0	0	0	0	1	0	0	0	16810	507	18	2	265	2	TYR	11	88911384	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	55916399	88911384	46095132	51	28445										
KCNA6	3742	broad.mit.edu	37	chr12	4919301	4919301	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	cgggagacttcccggaggccGgcgggggcgggggctgctgt	22	11	0	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:4919301G>A	uc001qng.2	+	1	960	c.94G>A	c.(94-96)GGC>AGC	p.G32S		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	32						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CCCGGAGGCCGGCGGGGGCGG	0.662										HNSCC(72;0.22)			0	0	0	0.045705	0	27	56										A	4919301	G	A	4919301	3	1	95	1	0	0	0	0	1	0	0	0	8007	1116	39	2	96	2	KCNA6	12	4919301	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		4919301	128932594	52	28446										
SP1	6667	broad.mit.edu	37	chr12	53776442	53776442	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ctactccagcaggctgtcccCctccaaggcctggctaataa	8	16	0	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:53776442C>G	uc001scw.2	+	3	808	c.711C>G	c.(709-711)CCC>CCG	p.P237P	SP1_uc010sog.1_Silent_p.P230P	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	237	Transactivation domain A (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		AGGCTGTCCCCCTCCAAGGCC	0.488													0	0	0	0.069288	0	24	61										G	53776442	C	G	53776442	2	3	95	1	0	0	0	0	0	0	0	1	14959	610	22	4		4	SP1	12	53776442	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	48857141	53776442	80075453	53	28447										
C12orf45	121053	broad.mit.edu	37	chr12	105381948	105381948	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tgtgtctgtattttcaggtaTatgggacaggttgctcatca	11	6	4	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:105381948T>A	uc001tlb.2	+	2	152	c.119T>A	c.(118-120)ATA>AAA	p.I40K		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	40											0						TTTTCAGGTATATGGGACAGG	0.438													0	0	0	0.02938	0	7	10										A	105381948	T	A	105381948	3	1	95	1	0	0	0	0	1	0	0	0	1691	1406	49	5	125	5	C12orf45	12	105381948	Missense_Mutation	SNP	T	TCGA-G2-A2EK-01A-22D-A18F-08	51605506	105381948	28469947	54	28448										
NBEA	26960	broad.mit.edu	37	chr13	36026232	36026232	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	atttttgttgtgattaggcaCggaagaagatgtagtaaagt	12	2	0	3			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr13:36026232C>T	uc001uvb.2	+	40	6514	c.6308C>T	c.(6307-6309)ACG>ATG	p.T2103M	NBEA_uc010abi.2_Missense_Mutation_p.T759M	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2103						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGATTAGGCACGGAAGAAGAT	0.308													0	0	0	0.09319	0	9	12										T	36026232	C	T	36026232	3	4	95	1	0	0	0	0	1	0	0	0	10187	536	19	2	6466	2	NBEA	13	36026232	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		36026232	79143646	55	28449										
MIPOL1	145282	broad.mit.edu	37	chr14	37892073	37892073	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	cttttaggcaaagttgttatCtatgcaacaagccagagaaa	8	7	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:37892073C>T	uc001wuc.2	+	12	1453	c.950C>T	c.(949-951)TCT>TTT	p.S317F	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Missense_Mutation_p.S286F|MIPOL1_uc001wud.2_Missense_Mutation_p.S317F|MIPOL1_uc010ams.2_Missense_Mutation_p.S317F|MIPOL1_uc001wue.2_Missense_Mutation_p.S286F|MIPOL1_uc010amt.2_Missense_Mutation_p.S136F	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	317	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAGTTGTTATCTATGCAACAA	0.323													0	0	0	0.058154	0	7	14										T	37892073	C	T	37892073	3	4	95	1	0	0	0	0	1	0	0	0	9593	913	32	1	984	1	MIPOL1	14	37892073	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		37892073	69457467	56	28450										
KIAA0831	22863	broad.mit.edu	37	chr14	55836491	55836491	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gggaagggatatcacaaaacCggggactaggcaagttctcc	13	9	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:55836491C>T	uc001xbx.1	-	10	1361	c.1325G>A	c.(1324-1326)CGG>CAG	p.R442Q	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Missense_Mutation_p.R329Q	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	442					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						ATCACAAAACCGGGGACTAGG	0.587													0	0	0	0.132662	0	16	43										T	55836491	C	T	55836491	3	4	95	1	0	0	0	0	1	0	0	0	8195	652	23	2	157	2	KIAA0831	14	55836491	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	17944418	55836491	51513049	57	28451										
SPTB	6710	broad.mit.edu	37	chr14	65259855	65259855	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tccagggcttcctgcagcctCtgctgacgcaggtccgcctg	12	16	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:65259855C>T	uc001xht.2	-	13	2580	c.2526G>A	c.(2524-2526)CAG>CAA	p.Q842Q	SPTB_uc001xhr.2_Silent_p.Q842Q|SPTB_uc001xhs.2_Silent_p.Q842Q|SPTB_uc001xhu.2_Silent_p.Q842Q	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	842	Spectrin 6.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTGCAGCCTCTGCTGACGCA	0.627													0	0	0	0.105934	0	13	50										T	65259855	C	T	65259855	2	4	95	1	0	0	0	0	0	0	0	1	15117	912	32	1		1	SPTB	14	65259855	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	9423364	65259855	42089685	58	28452										
TTLL5	23093	broad.mit.edu	37	chr14	76186104	76186104	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	cgatccagaagtggaggattAtggaaacaaatggagcatga	13	5	0	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:76186104A>G	uc001xrx.2	+	11	1074	c.869A>G	c.(868-870)TAT>TGT	p.Y290C	TTLL5_uc010ask.1_Missense_Mutation_p.Y290C|TTLL5_uc001xry.1_Intron	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	290	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		GTGGAGGATTATGGAAACAAA	0.388													0	0	0	0.115264	0	2	23										G	76186104	A	G	76186104	3	3	95	1	0	0	0	0	1	0	0	0	16727	449	16	5	907	5	TTLL5	14	76186104	Missense_Mutation	SNP	A	TCGA-G2-A2EK-01A-22D-A18F-08	10926249	76186104	31163436	59	28453										
HERC2	8924	broad.mit.edu	37	chr15	28467317	28467317	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	aactgtggcagaagcaccttGagcagaagcattcatatctt	9	9	2	3			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:28467317G>C	uc001zbj.2	-	36	5615	c.5509C>G	c.(5509-5511)CAA>GAA	p.Q1837E		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1837					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GAAGCACCTTGAGCAGAAGCA	0.493													0	0	0	0.080935	0	8	26										C	28467317	G	C	28467317	3	2	95	1	0	0	0	0	1	0	0	0	7058	1299	45	1	9227	1	HERC2	15	28467317	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		28467317	74064075	60	28454										
CASC5	57082	broad.mit.edu	37	chr15	40914878	40914878	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gacagatagctgtaaaagttGaaaaatgtggtaaaagtccc	10	5	0	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:40914878G>C	uc010bbs.1	+	11	2655	c.2494G>C	c.(2494-2496)GAA>CAA	p.E832Q	CASC5_uc010ucq.1_Missense_Mutation_p.E656Q|CASC5_uc001zme.2_Missense_Mutation_p.E806Q|CASC5_uc010bbt.1_Missense_Mutation_p.E806Q	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	832					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGTAAAAGTTGAAAAATGTGG	0.358													0	0	0	0.02938	0	6	17										C	40914878	G	C	40914878	3	2	95	1	0	0	0	0	1	0	0	0	2663	1291	45	1	2532	1	CASC5	15	40914878	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	12447561	40914878	61616514	61	28455										
DENND4A	10260	broad.mit.edu	37	chr15	65988761	65988761	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	acttgtaccagtgaggcgaaCgatactggaagaattttgat	11	6	0	3			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:65988761C>T	uc002aph.2	-	21	3271	c.2893G>A	c.(2893-2895)GTT>ATT	p.V965I	DENND4A_uc002api.2_Missense_Mutation_p.V1008I|DENND4A_uc002apj.3_Missense_Mutation_p.V965I	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	965					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GTGAGGCGAACGATACTGGAA	0.383													0	0	0	0.021553	0	5	26										T	65988761	C	T	65988761	3	4	95	1	0	0	0	0	1	0	0	0	4433	536	19	2	2746	2	DENND4A	15	65988761	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	25073883	65988761	36542631	62	28456										
NOXO1	124056	broad.mit.edu	37	chr16	2029466	2029466	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gtctgacgtttccaacacgcGcacgcgcgcccccgcgggca	12	18	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:2029466G>T	uc002cnx.2	-	7	797	c.793C>A	c.(793-795)CGC>AGC	p.R265S	NOXO1_uc002cnz.2_Missense_Mutation_p.R259S|NOXO1_uc002coa.2_Missense_Mutation_p.R264S|NOXO1_uc002cny.2_Missense_Mutation_p.R260S	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	265	SH3 2.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						TCCAACACGCGCACGCGCGCC	0.706													1	0	2.0095e-06	0.02938	2.19789e-06	6	28										T	2029466	G	T	2029466	3	4	95	1	0	0	0	0	1	0	0	0	10561	1087	38	4	345	4	NOXO1	16	2029466	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		2029466	88325287	63	28457										
CD19	930	broad.mit.edu	37	chr16	28948412	28948412	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	atggaaacccgagcagcgacGtccaggcggatggagccttg	15	11	0	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:28948412G>A	uc002drs.2	+	8	1215	c.1153G>A	c.(1153-1155)GTC>ATC	p.V385I	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.V385I	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	385	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						GAGCAGCGACGTCCAGGCGGA	0.682													0	0	0	0.014758	0	4	17										A	28948412	G	A	28948412	3	1	95	1	0	0	0	0	1	0	0	0	2973	1145	40	2	1183	2	CD19	16	28948412	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	26918946	28948412	61406341	64	28458										
CX3CL1	6376	broad.mit.edu	37	chr16	57416628	57416628	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ctctgtggtccctgtctcctCagaagggacccccagcaggg	12	15	3	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:57416628C>T	uc002eli.2	+	3	945	c.878C>T	c.(877-879)TCA>TTA	p.S293L		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	293	Mucin-like stalk.|Extracellular (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						CCTGTCTCCTCAGAAGGGACC	0.672													0	0	0	0.043863	0	19	55										T	57416628	C	T	57416628	3	4	95	1	0	0	0	0	1	0	0	0	4074	838	29	1	888	1	CX3CL1	16	57416628	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	28468216	57416628	32938125	65	28459										
ADAMTS18	170692	broad.mit.edu	37	chr16	77465414	77465414	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tgcagggagcttctggcattCtgcgccgatcgctttttcct	11	12	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:77465414C>G	uc002ffc.3	-	3	692	c.273G>C	c.(271-273)CAG>CAC	p.Q91H	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	91					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TTCTGGCATTCTGCGCCGATC	0.478													0	0	0	0.139131	0	59	160										G	77465414	C	G	77465414	3	3	95	1	0	0	0	0	1	0	0	0	263	912	32	1	3476	1	ADAMTS18	16	77465414	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	20048786	77465414	12889339	66	28460										
SLFN13	146857	broad.mit.edu	37	chr17	33769076	33769076	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ccctctgcatcctgctccctGagaatggtgtagagaatggg	12	11	1	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:33769076G>C	uc002hjk.1	-	3	1758	c.1428C>G	c.(1426-1428)CTC>CTG	p.L476L	SLFN13_uc010wch.1_Silent_p.L476L|SLFN13_uc002hjl.2_Silent_p.L476L|SLFN13_uc010ctt.2_Silent_p.L158L|SLFN13_uc002hjm.2_Silent_p.L145L	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	476						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CCTGCTCCCTGAGAATGGTGT	0.557													0	0	0	0.132662	0	14	100										C	33769076	G	C	33769076	2	2	95	1	0	0	0	0	0	0	0	1	14736	1277	45	1		1	SLFN13	17	33769076	Silent	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08		33769076	47426134	67	28461										
UBTF	7343	broad.mit.edu	37	chr17	42286824	42286824	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gatgcgctgccagcgactgcCgatctccaccatgcgctcct	10	17	1	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:42286824C>T	uc002igb.2	-	16	1868	c.1801G>A	c.(1801-1803)GGC>AGC	p.G601S	UBTF_uc002igc.2_Missense_Mutation_p.G564S|UBTF_uc010czs.2_Missense_Mutation_p.G601S|UBTF_uc002igd.2_Missense_Mutation_p.G564S|UBTF_uc010czt.2_Missense_Mutation_p.G601S|UBTF_uc002ige.2_Missense_Mutation_p.G564S	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	601	HMG box 6.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CAGCGACTGCCGATCTCCACC	0.597													0	0	0	0.080935	0	11	46										T	42286824	C	T	42286824	3	4	95	1	0	0	0	0	1	0	0	0	16906	652	23	2	513	2	UBTF	17	42286824	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	8517748	42286824	38908386	68	28462										
CBX1	10951	broad.mit.edu	37	chr17	46154251	46154251	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	agaatcccttccactttaggAggtactccactttgcccttt	6	13	0	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:46154251A>G	uc002ind.3	-	2	597	c.116T>C	c.(115-117)CTC>CCC	p.L39P	CBX1_uc002ine.3_Missense_Mutation_p.L39P	NM_006807	NP_006798	P83916	CBX1_HUMAN	heterochromatin protein 1-beta	39	Chromo 1.					nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding				0						CCACTTTAGGAGGTACTCCAC	0.463													0	0	0	0.009096	0	3	146										G	46154251	A	G	46154251	3	3	95	1	0	0	0	0	1	0	0	0	2717	304	11	5	457	5	CBX1	17	46154251	Missense_Mutation	SNP	A	TCGA-G2-A2EK-01A-22D-A18F-08	3867427	46154251	35040959	69	28463										
CARD14	79092	broad.mit.edu	37	chr17	78166304	78166304	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ctggcctgtctttggcagctCaagcaggaagccaggaccag	13	12	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:78166304C>G	uc002jxw.1	+	9	1437	c.1242C>G	c.(1240-1242)CTC>CTG	p.L414L	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Silent_p.L414L|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Silent_p.L177L|CARD14_uc010dhu.1_Silent_p.L212L	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	414					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TTTGGCAGCTCAAGCAGGAAG	0.612													0	0	0	0.049695	0	19	59										G	78166304	C	G	78166304	2	3	95	1	0	0	0	0	0	0	0	1	2646	813	29	1		1	CARD14	17	78166304	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	32012053	78166304	3028906	70	28464										
MPND	84954	broad.mit.edu	37	chr19	4357557	4357557	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ccccgagtccaagatctcacCtttctgggtgatgcctcctc	8	16	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr19:4357557C>G	uc002mae.2	+	10	1278	c.1211C>G	c.(1210-1212)CCT>CGT	p.P404R	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Missense_Mutation_p.P354R|MPND_uc002maf.2_Missense_Mutation_p.P404R|MPND_uc002mah.2_Missense_Mutation_p.P292R|MPND_uc002mai.2_Missense_Mutation_p.P263R	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	404							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGATCTCACCTTTCTGGGTG	0.672													0	0	0	0.09319	0	7	26										G	4357557	C	G	4357557	3	3	95	1	0	0	0	0	1	0	0	0	9731	681	24	4	1249	4	MPND	19	4357557	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		4357557	54771426	71	28465										
KIAA1543	57662	broad.mit.edu	37	chr19	7675446	7675446	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tttctgtgcctctcgccttcCtcgtggctgccccctgtccc	8	19	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr19:7675446C>T	uc002mgv.3	+	6	946	c.845C>T	c.(844-846)CCT>CTT	p.P282L	KIAA1543_uc002mgu.3_Missense_Mutation_p.P309L	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	282	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						TCTCGCCTTCCTCGTGGCTGC	0.642													0	0	0	0.139131	0	63	164										T	7675446	C	T	7675446	3	4	95	1	0	0	0	0	1	0	0	0	8243	681	24	2	956	2	KIAA1543	19	7675446	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	3317889	7675446	51453537	72	28466										
ZNF91	7644	broad.mit.edu	37	chr19	23543307	23543307	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	cacattctttacatttgtagGgtttctctccagtatgaatt	6	8	2	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr19:23543307G>A	uc002nre.2	-	4	2587	c.2474C>T	c.(2473-2475)CCC>CTC	p.P825L	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.P793L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	825						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				ACATTTGTAGGGTTTCTCTCC	0.403													0	0	0	0.080935	0	11	52										A	23543307	G	A	23543307	3	1	95	1	0	0	0	0	1	0	0	0	18197	1232	43	2	1105	2	ZNF91	19	23543307	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	15867861	23543307	35585676	73	28467										
CDH26	60437	broad.mit.edu	37	chr20	58545166	58545166	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	taccagcctctacggcgatcCaagagaagatgggttatcac	10	11	2	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr20:58545166C>T	uc002ybe.2	+	3	456	c.156C>T	c.(154-156)TCC>TCT	p.S52S	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	52	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TACGGCGATCCAAGAGAAGAT	0.502													0	0	0	0.108266	0	24	112										T	58545166	C	T	58545166	2	4	95	1	0	0	0	0	0	0	0	1	3110	581	21	2		2	CDH26	20	58545166	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		58545166	4480354	74	28468										
LSM14B	149986	broad.mit.edu	37	chr20	60697745	60697745	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gagcggctcctcaggcacccCgtatctgggcagcaagatca	12	14	3	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr20:60697745C>T	uc010gjy.1	+	1	229	c.23C>T	c.(22-24)CCG>CTG	p.P8L	LSM14B_uc002ybt.2_Missense_Mutation_p.P8L|LSM14B_uc010gjx.1_Missense_Mutation_p.P8L|LSM14B_uc002ybv.2_Missense_Mutation_p.P8L|LSM14B_uc010gjz.1_5'Flank|LSM14B_uc010zzz.1_5'Flank	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	8					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			TCAGGCACCCCGTATCTGGGC	0.542													0	0	0	0.021553	0	6	33										T	60697745	C	T	60697745	3	4	95	1	0	0	0	0	1	0	0	0	9055	652	23	2	25	2	LSM14B	20	60697745	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	2152579	60697745	2327775	75	28469										
COL18A1	80781	broad.mit.edu	37	chr21	46914788	46914788	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tcttgcagggtccatacggaCggccggggtacaagggagag	17	9	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr21:46914788C>T	uc011afs.1	+	27	3658	c.3637C>T	c.(3637-3639)CGG>TGG	p.R1213W	COL18A1_uc002zhg.2_Missense_Mutation_p.R798W|COL18A1_uc002zhi.2_Missense_Mutation_p.R978W	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1213	Triple-helical region 6 (COL6).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TCCATACGGACGGCCGGGGTA	0.682													0	0	0	0.047766	0	7	22										T	46914788	C	T	46914788	3	4	95	1	0	0	0	0	1	0	0	0	3675	527	19	2	3857	2	COL18A1	21	46914788	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		46914788	1215107	76	28470										
GGT1	2678	broad.mit.edu	37	chr22	25011027	25011027	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ggaaaagctgaggtcatcaaCgcccgcgaggtggcccccag	14	13	2	1	rs112364951	by1000genomes	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:25011027C>T	uc003aan.1	+	7	802	c.315C>T	c.(313-315)AAC>AAT	p.N105N	GGT1_uc003aas.1_Silent_p.N105N|GGT1_uc003aat.1_Silent_p.N105N|GGT1_uc003aau.1_Silent_p.N105N|GGT1_uc003aav.1_Silent_p.N105N|GGT1_uc003aaw.1_Silent_p.N105N|GGT1_uc003aax.1_Silent_p.N105N	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	105	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	AGGTCATCAACGCCCGCGAGG	0.637													0	0	0	0.009096	0	4	60										T	25011027	C	T	25011027	2	4	95	1	0	0	0	0	0	0	0	1	6361	535	19	2		2	GGT1	22	25011027	Silent	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		25011027	26293539	77	28471										
LARGE	9215	broad.mit.edu	37	chr22	33780235	33780235	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	tccctctctgcggtcagcctCcacatctgctcccatttcat	5	18	4	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:33780235C>G	uc003and.3	-	9	1527	c.948G>C	c.(946-948)TGG>TGC	p.W316C	LARGE_uc011amd.1_Missense_Mutation_p.W115C|LARGE_uc003ane.3_Missense_Mutation_p.W316C|LARGE_uc010gwp.2_Missense_Mutation_p.W316C|LARGE_uc011ame.1_Missense_Mutation_p.W248C|LARGE_uc011amf.1_Missense_Mutation_p.W316C|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	316	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				CGGTCAGCCTCCACATCTGCT	0.488													0	0	0	0.059317	0	35	85										G	33780235	C	G	33780235	3	3	95	1	0	0	0	0	1	0	0	0	8627	856	30	1	1354	1	LARGE	22	33780235	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	8769208	33780235	17524331	78	28472										
CYTH4	27128	broad.mit.edu	37	chr22	37699360	37699360	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gcctccacaatcccaacgtcCgggacaggccgccttttgag	10	16	0	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:37699360C>T	uc003arf.2	+	8	729	c.613C>T	c.(613-615)CGG>TGG	p.R205W	CYTH4_uc003are.2_Missense_Mutation_p.R205W|CYTH4_uc011amw.1_Missense_Mutation_p.R148W|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	205	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCCAACGTCCGGGACAGGCC	0.612													0	0	0	0.058154	0	9	52										T	37699360	C	T	37699360	3	4	95	1	0	0	0	0	1	0	0	0	4206	643	23	2	643	2	CYTH4	22	37699360	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	3919125	37699360	13605206	79	28473										
PLXNB2	23654	broad.mit.edu	37	chr22	50718455	50718455	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	ttgaggtactggtacaggcaGatggacatccagttggacag	14	7	0	2			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:50718455G>C	uc003bkv.3	-	26	4327	c.4221C>G	c.(4219-4221)ATC>ATG	p.I1407M	PLXNB2_uc003bkt.1_Missense_Mutation_p.I199M|PLXNB2_uc003bku.1_Missense_Mutation_p.I392M	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1407	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTACAGGCAGATGGACATCC	0.607													0	0	0	0.058154	0	10	46										C	50718455	G	C	50718455	3	2	95	1	0	0	0	0	1	0	0	0	12124	932	33	1	1343	1	PLXNB2	22	50718455	Missense_Mutation	SNP	G	TCGA-G2-A2EK-01A-22D-A18F-08	13019095	50718455	586111	80	28474										
TYMP	1890	broad.mit.edu	37	chr22	50968116	50968116	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	gcgcgggtggggccccggttCccggggtcatcaaggctgcc	18	14	2	0			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:50968116C>T	uc003bmb.3	-	1	143	c.23G>A	c.(22-24)GGA>GAA	p.G8E	TYMP_uc003bmc.3_Missense_Mutation_p.G8E|TYMP_uc003bmd.3_Missense_Mutation_p.G8E|TYMP_uc010hbd.2_Missense_Mutation_p.G8E|TYMP_uc003bme.3_Missense_Mutation_p.G8E|TYMP_uc003bmf.3_Missense_Mutation_p.G8E|TYMP_uc011arz.1_Missense_Mutation_p.G8E	NM_001113756	NP_001107228	P19971	TYPH_HUMAN	endothelial cell growth factor 1	8					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			ovary(1)	1		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GGCCCCGGTTCCCGGGGTCAT	0.716													0	0	0	0.014758	0	4	25										T	50968116	C	T	50968116	3	4	95	1	0	0	0	0	1	0	0	0	16808	855	30	1	1461	1	TYMP	22	50968116	Missense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08	249661	50968116	336450	81	28475										
KDM6A	7403	broad.mit.edu	37	chrX	44870260	44870260	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.317073170731707	26	7.03682081505954e-08	3.21014799154334	6.7906976744186	1.86744186046512	0.428655833067358	0.656703672938893	18	acttccattataatgcatttCagtggtaagttgacataaaa	6	6	1	1			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chrX:44870260C>T	uc004dge.3	+	5	814	c.439C>T	c.(439-441)CAG>TAG	p.Q147*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q147*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q147*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q147*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q147*|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	147	TPR 2.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(2)|p.?(1)		kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAATGCATTTCAGTGGTAAGT	0.318			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.069234	0	10	4										T	44870260	C	T	44870260	4	4	95	1	0	0	0	0	0	1	0	0	8137	827	29	1	457	1	KDM6A	23	44870260	Nonsense_Mutation	SNP	C	TCGA-G2-A2EK-01A-22D-A18F-08		44870260	110400300	82	28476										
MIB2	142678	broad.mit.edu	37	chr1	1564037	1564037	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acgtggcgctgcagcgtcatCagctgctgcccctggtggct	14	14	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:1564037C>G	uc001agg.2	+	16	2438	c.2311C>G	c.(2311-2313)CAG>GAG	p.Q771E	MIB2_uc001agh.2_Missense_Mutation_p.Q757E|MIB2_uc001agi.2_Missense_Mutation_p.Q767E|MIB2_uc001agj.2_Missense_Mutation_p.Q612E|MIB2_uc001agk.2_Missense_Mutation_p.Q706E|MIB2_uc001agl.1_Missense_Mutation_p.Q727E|MIB2_uc001agm.2_Missense_Mutation_p.Q648E|MIB2_uc010nyq.1_Missense_Mutation_p.Q727E|MIB2_uc009vkh.2_Missense_Mutation_p.Q577E|MIB2_uc001agn.2_Missense_Mutation_p.Q403E|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	771	ANK 8.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCAGCGTCATCAGCTGCTGCC	0.701													0	0	0	0.000248	0	4	5										G	1564037	C	G	1564037	3	3	96	1	0	0	0	0	1	0	0	0	9567	827	29	1	2544	1	MIB2	1	1564037	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		1564037	247686584	1	28477										
MEGF6	1953	broad.mit.edu	37	chr1	3421837	3421837	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacactcgccgctcacggagTcacaggccacgcccactggg	11	18	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:3421837T>C	uc001akl.2	-	17	2350	c.2123A>G	c.(2122-2124)GAC>GGC	p.D708G	MEGF6_uc001akk.2_Missense_Mutation_p.D603G	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	708						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCTCACGGAGTCACAGGCCAC	0.692													0	0	0	0.001168	0	6	35										C	3421837	T	C	3421837	3	2	96	1	0	0	0	0	1	0	0	0	9462	1667	58	5	2586	5	MEGF6	1	3421837	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	1857800	3421837	245828784	2	28478										
NOL9	79707	broad.mit.edu	37	chr1	6589194	6589194	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatgggtaggggcgacatcaGagtgggtaatccggagtgcg	18	6	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:6589194G>C	uc001ans.2	-	10	1704	c.1685C>G	c.(1684-1686)TCT>TGT	p.S562C	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	562					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		GGCGACATCAGAGTGGGTAAT	0.468													0	0	0	0.001984	0	6	46										C	6589194	G	C	6589194	3	2	96	1	0	0	0	0	1	0	0	0	10528	942	33	1	435	1	NOL9	1	6589194	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3167357	6589194	242661427	3	28479										
RERE	473	broad.mit.edu	37	chr1	8424172	8424172	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccactgagcccatcatcctCttccttgacgggtttgaaca	7	15	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:8424172C>G	uc001ape.2	-	16	2494	c.1684G>C	c.(1684-1686)GAG>CAG	p.E562Q	RERE_uc001apf.2_Missense_Mutation_p.E562Q|RERE_uc010nzx.1_Missense_Mutation_p.E294Q|RERE_uc001apd.2_Missense_Mutation_p.E8Q	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	562					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CCATCATCCTCTTCCTTGACG	0.587													0	0	0	0.001855	0	13	77										G	8424172	C	G	8424172	3	3	96	1	0	0	0	0	1	0	0	0	13231	922	32	1	3052	1	RERE	1	8424172	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1834978	8424172	240826449	4	28480										
SLC25A33	84275	broad.mit.edu	37	chr1	9633411	9633411	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttttttttccagcttttatCacaaattccttaatgaatcc	2	9	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:9633411C>A	uc001apw.2	+	5	646	c.423C>A	c.(421-423)ATC>ATA	p.I141I	SLC25A33_uc001apx.2_Silent_p.I74I	NM_032315	NP_115691	Q9BSK2	S2533_HUMAN	mitochondrial carrier protein MGC4399	141	Solcar 2.|Helical; Name=3; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CAGCTTTTATCACAAATTCCT	0.294													1	0	0.00116845	0.001168	0.0013894	6	20										A	9633411	C	A	9633411	2	1	96	1	0	0	0	0	0	0	0	1	14497	816	29	3		3	SLC25A33	1	9633411	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1209239	9633411	239617210	5	28481										
SRM	6723	broad.mit.edu	37	chr1	11116794	11116794	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccatgcctggcaggaacttCttggagacttggatgacatc	12	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:11116794C>A	uc001arz.1	-	4	493	c.402G>T	c.(400-402)AAG>AAT	p.K134N	SRM_uc001ary.1_5'UTR	NM_003132	NP_003123	P19623	SPEE_HUMAN	spermidine synthase	134					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity				0	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	GCAGGAACTTCTTGGAGACTT	0.577													1	0	6.40141e-05	0.000978	7.64982e-05	11	48										A	11116794	C	A	11116794	3	1	96	1	0	0	0	0	1	0	0	0	15150	912	32	3	526	3	SRM	1	11116794	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1483383	11116794	238133827	6	28482										
VPS13D	55187	broad.mit.edu	37	chr1	12326961	12326961	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taaaacttctagcagagtctCttcctcgaagaaattcctcg	6	11	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:12326961C>G	uc001atv.2	+	14	1759	c.1618C>G	c.(1618-1620)CTT>GTT	p.L540V	VPS13D_uc001atw.2_Missense_Mutation_p.L540V	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	540					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGCAGAGTCTCTTCCTCGAAG	0.368													0	0	0	0.001882	0	22	42										G	12326961	C	G	12326961	3	3	96	1	0	0	0	0	1	0	0	0	17189	913	32	1	1668	1	VPS13D	1	12326961	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1210167	12326961	236923660	7	28483										
VPS13D	55187	broad.mit.edu	37	chr1	12336868	12336868	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgacaaaattcttaccaaaGagcaagagtcccttattaag	6	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:12336868G>C	uc001atv.2	+	19	3364	c.3223G>C	c.(3223-3225)GAG>CAG	p.E1075Q	VPS13D_uc001atw.2_Missense_Mutation_p.E1075Q|VPS13D_uc001atx.2_Missense_Mutation_p.E263Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1075					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TCTTACCAAAGAGCAAGAGTC	0.438											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.002836	0	32	80										C	12336868	G	C	12336868	3	2	96	1	0	0	0	0	1	0	0	0	17189	943	33	1	3293	1	VPS13D	1	12336868	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9907	12336868	236913753	8	28484										
ARHGEF19	128272	broad.mit.edu	37	chr1	16532692	16532692	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacctctcgctggtgctcttGacctcgggcagtttggaaaa	11	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:16532692G>C	uc001ayc.1	-	7	1418	c.1281C>G	c.(1279-1281)GTC>GTG	p.V427V	ARHGEF19_uc009voo.1_5'UTR|ARHGEF19_uc001ayb.1_5'UTR	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	427	DH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTGCTCTTGACCTCGGGCA	0.647													0	0	0	0.001984	0	5	14										C	16532692	G	C	16532692	2	2	96	1	0	0	0	0	0	0	0	1	902	1277	45	1		1	ARHGEF19	1	16532692	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4195824	16532692	232717929	9	28485										
KLHDC7A	127707	broad.mit.edu	37	chr1	18808555	18808555	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggccctccacccgaggcttCagccggaaggagagccttct	12	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:18808555C>T	uc001bax.2	+	1	1132	c.1080C>T	c.(1078-1080)TTC>TTT	p.F360F	KLHDC7A_uc009vpg.2_Silent_p.F142F	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	360	Kelch 1.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCCGAGGCTTCAGCCGGAAGG	0.692													0	0	0	0.00308	0	5	23										T	18808555	C	T	18808555	2	4	96	1	0	0	0	0	0	0	0	1	8360	825	29	1		1	KLHDC7A	1	18808555	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2275863	18808555	230442066	10	28486										
UBR4	23352	broad.mit.edu	37	chr1	19494588	19494588	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagggaagcagccaggggcaGactttggctacagagagtcc	15	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:19494588G>T	uc001bbi.2	-	28	3836	c.3832C>A	c.(3832-3834)CTG>ATG	p.L1278M	UBR4_uc001bbm.1_Missense_Mutation_p.L489M	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1278					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCCAGGGGCAGACTTTGGCTA	0.512													1	0	6.05902e-23	0.003755	7.72123e-23	36	78										T	19494588	G	T	19494588	3	4	96	1	0	0	0	0	1	0	0	0	16901	933	33	3	12035	3	UBR4	1	19494588	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	686033	19494588	229756033	11	28487										
CLIC4	25932	broad.mit.edu	37	chr1	25167380	25167380	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatacctgtcccagtgataaGgaggttgaaatagcatatag	10	6	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:25167380G>A	uc001bjo.2	+	6	999	c.714G>A	c.(712-714)AAG>AAA	p.K238K	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Silent_p.K218K	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	238	GST C-terminal.				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		CCAGTGATAAGGAGGTTGAAA	0.398													0	0	0	0.004878	0	34	78										A	25167380	G	A	25167380	2	1	96	1	0	0	0	0	0	0	0	1	3528	991	35	2		2	CLIC4	1	25167380	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5672792	25167380	224083241	12	28488										
FAM46B	115572	broad.mit.edu	37	chr1	27332842	27332842	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcggtgctgggccggggccGgaagccccgcaccaggaggt	18	13	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:27332842G>A	uc010ofj.1	-	2	1043	c.871C>T	c.(871-873)CGG>TGG	p.R291W		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	291										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		GGCCGGGGCCGGAAGCCCCGC	0.677													0	0	0	0.00308	0	7	33										A	27332842	G	A	27332842	3	1	96	1	0	0	0	0	1	0	0	0	5566	1115	39	2	410	2	FAM46B	1	27332842	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2165462	27332842	221917779	13	28489										
TAF12	6883	broad.mit.edu	37	chr1	28931934	28931934	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgtagggtcggatttcttCagagccaaatcctgggatcc	11	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:28931934C>T	uc001bqw.2	-	4	493	c.400G>A	c.(400-402)GAA>AAA	p.E134K	TAF12_uc001bqx.2_Missense_Mutation_p.E134K|TAF12_uc001bqy.2_Missense_Mutation_p.E134K|TAF12_uc009vti.2_Missense_Mutation_p.E134K	NM_005644	NP_005635	Q16514	TAF12_HUMAN	TAF12 RNA polymerase II, TATA box binding	134					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Renal(390;0.00121)|Breast(348;0.00502)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)		Colorectal(126;3.21e-08)|COAD - Colon adenocarcinoma(152;1.74e-06)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(1967;0.0109)|BRCA - Breast invasive adenocarcinoma(304;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CGGATTTCTTCAGAGCCAAAT	0.517													0	0	0	0.003271	0	35	88										T	28931934	C	T	28931934	3	4	96	1	0	0	0	0	1	0	0	0	15513	835	29	1	93	1	TAF12	1	28931934	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1599092	28931934	220318687	14	28490										
CCDC28B	79140	broad.mit.edu	37	chr1	32669900	32669900	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggaggacgatgaagaggaaGaggatggggtcactgagggg	21	3	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:32669900G>C	uc001bul.1	+	4	577	c.445G>C	c.(445-447)GAG>CAG	p.E149Q	CCDC28B_uc001buk.2_Missense_Mutation_p.E149Q|IQCC_uc001bum.2_5'Flank|IQCC_uc009vua.2_5'Flank|IQCC_uc010ogz.1_5'Flank	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	149											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TGAAGAGGAAGAGGATGGGGT	0.582													0	0	0	0.006214	0	9	55										C	32669900	G	C	32669900	3	2	96	1	0	0	0	0	1	0	0	0	2803	943	33	1	455	1	CCDC28B	1	32669900	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3737966	32669900	216580721	15	28491										
CSMD2	114784	broad.mit.edu	37	chr1	33985159	33985159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gctgactgtgaactccgcctCgctggccatgatgtctgtgg	13	12	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:33985159C>T	uc001bxn.1	-	69	10452	c.10423G>A	c.(10423-10425)GAG>AAG	p.E3475K	CSMD2_uc001bxm.1_Missense_Mutation_p.E3619K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3475	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AACTCCGCCTCGCTGGCCATG	0.612													0	0	0	0.002222	0	44	178										T	33985159	C	T	33985159	3	4	96	1	0	0	0	0	1	0	0	0	3945	893	31	1	44	1	CSMD2	1	33985159	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1315259	33985159	215265462	16	28492										
CLSPN	63967	broad.mit.edu	37	chr1	36202663	36202663	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctttgggctggtttagcagtGagcctgtcttcacctgagga	13	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:36202663G>C	uc001bzi.2	-	24	3841	c.3761C>G	c.(3760-3762)TCA>TGA	p.S1254*	CLSPN_uc009vux.2_Nonsense_Mutation_p.S1190*	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	1254					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTTAGCAGTGAGCCTGTCTT	0.463													0	0	0	0.001523	0	21	107										C	36202663	G	C	36202663	4	2	96	1	0	0	0	0	0	1	0	0	3560	1294	45	1	266	1	CLSPN	1	36202663	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2217504	36202663	213047958	17	28493										
MRPS15	64960	broad.mit.edu	37	chr1	36927747	36927747	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgtagagggaggtgggtcatCatccagcctagactgggctg	16	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:36927747C>T	uc001cas.2	-	3	357	c.193G>A	c.(193-195)GAT>AAT	p.D65N		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	65				GGGSAKFPFNQWGLQPRSLLLQAARGYVVRKPAQSRLDDDP PPSTLLKDYQNV -> AVGAPSFLSTSGACSLEVSSSRPRA DMSSGNQPSLGWMMTHLLLRCSKTTRMS (in Ref. 2; AAG44697).	translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGTGGGTCATCATCCAGCCTA	0.537													0	0	0	0.002096	0	31	39										T	36927747	C	T	36927747	3	4	96	1	0	0	0	0	1	0	0	0	9825	826	29	1	604	1	MRPS15	1	36927747	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	725084	36927747	212322874	18	28494										
EPHA10	284656	broad.mit.edu	37	chr1	38192827	38192827	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccaggacgaggagggccgaGatggtcactacggtgacgac	16	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:38192827G>A	uc009vvi.2	-	8	1805	c.1719C>T	c.(1717-1719)ATC>ATT	p.I573I	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	573	Helical; (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGAGGGCCGAGATGGTCACTA	0.637													0	0	0	0.001168	0	6	26										A	38192827	G	A	38192827	2	1	96	1	0	0	0	0	0	0	0	1	5166	932	33	1		1	EPHA10	1	38192827	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1265080	38192827	211057794	19	28495										
KIAA0754	643314	broad.mit.edu	37	chr1	39879406	39879406	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcccaccccagaggaatccGcctccgcagctgttgcagtg	11	16	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:39879406G>A	uc009vvt.1	+	1	4231	c.3469G>A	c.(3469-3471)GCC>ACC	p.A1157T	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	1021	Ala-rich.|12.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAGGAATCCGCCTCCGCAGC	0.682													0	0	0	0.001168	0	6	33										A	39879406	G	A	39879406	3	1	96	1	0	0	0	0	1	0	0	0	8192	1087	38	2	3471	2	KIAA0754	1	39879406	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1686579	39879406	209371215	20	28496										
NT5C1A	84618	broad.mit.edu	37	chr1	40131848	40131848	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgtgtagatctgctgctcctCgtccatgcgaaacaaggctc	10	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:40131848C>G	uc001cdq.1	-	2	196	c.196G>C	c.(196-198)GAG>CAG	p.E66Q		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	66					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TGCTGCTCCTCGTCCATGCGA	0.582													0	0	0	0.001855	0	13	60										G	40131848	C	G	40131848	3	3	96	1	0	0	0	0	1	0	0	0	10685	893	31	1	930	1	NT5C1A	1	40131848	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	252442	40131848	209118773	21	28497										
KIAA0467	23334	broad.mit.edu	37	chr1	43896036	43896036	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcagtgacctggagttttcaGaggctgagcttatgggagaa	14	6	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43896036G>C	uc001cjk.1	+	16	2221	c.1759G>C	c.(1759-1761)GAG>CAG	p.E587Q		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1486						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGAGTTTTCAGAGGCTGAGCT	0.522													0	0	0	0.008361	0	27	59										C	43896036	G	C	43896036	3	2	96	1	0	0	0	0	1	0	0	0	8178	943	33	1	1813	1	KIAA0467	1	43896036	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3764188	43896036	205354585	22	28498										
KIAA0467	23334	broad.mit.edu	37	chr1	43896196	43896196	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgcctgctgtgtggtcactGagagtgacccagagctagag	14	10	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43896196G>T	uc001cjk.1	+	17	2275	c.1813G>T	c.(1813-1815)GAG>TAG	p.E605*		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1504						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGTGGTCACTGAGAGTGACCC	0.562													1	0	4.22769e-11	0.00632	5.26178e-11	26	53										T	43896196	G	T	43896196	4	4	96	1	0	0	0	0	0	1	0	0	8178	1291	45	3	1871	3	KIAA0467	1	43896196	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	160	43896196	205354425	23	28499										
KIAA0467	23334	broad.mit.edu	37	chr1	43905590	43905590	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcttcgattggatgtgtggGaaaaggggaacattagtatt	15	3	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43905590G>C	uc001cjk.1	+	36	4846	c.4384G>C	c.(4384-4386)GAA>CAA	p.E1462Q		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2361						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGATGTGTGGGAAAAGGGGAA	0.577													0	0	0	0.007291	0	27	45										C	43905590	G	C	43905590	3	2	96	1	0	0	0	0	1	0	0	0	8178	1175	41	1	4518	1	KIAA0467	1	43905590	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9394	43905590	205345031	24	28500										
KIAA0467	23334	broad.mit.edu	37	chr1	43908143	43908143	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgacctacaactgggctccaGacctgggggcagcattgggc	14	12	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:43908143G>C	uc001cjk.1	+	43	5770	c.5308G>C	c.(5308-5310)GAC>CAC	p.D1770H		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2669						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGGGCTCCAGACCTGGGGGC	0.617													0	0	0	0.00333	0	24	55										C	43908143	G	C	43908143	3	2	96	1	0	0	0	0	1	0	0	0	8178	942	33	1	5470	1	KIAA0467	1	43908143	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2553	43908143	205342478	25	28501										
HECTD3	79654	broad.mit.edu	37	chr1	45472910	45472910	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctgtagtccaggggcttttCatatttgtcagagggcttga	12	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:45472910C>T	uc009vxk.2	-	11	1635	c.1537G>A	c.(1537-1539)GAA>AAA	p.E513K	HECTD3_uc001cmx.3_5'Flank|HECTD3_uc001cmy.3_Missense_Mutation_p.E123K|HECTD3_uc010olh.1_Missense_Mutation_p.E229K	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	513	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					AGGGGCTTTTCATATTTGTCA	0.413													0	0	0	0.00278	0	20	101										T	45472910	C	T	45472910	3	4	96	1	0	0	0	0	1	0	0	0	7041	835	29	1	1092	1	HECTD3	1	45472910	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1564767	45472910	203777711	26	28502										
ZSWIM5	57643	broad.mit.edu	37	chr1	45671765	45671765	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acgggctccgggatccgctcGaagcgctcctccacccgttc	11	18	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:45671765G>T	uc001cnd.2	-	1	486	c.258C>A	c.(256-258)TTC>TTA	p.F86L		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	86							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GGATCCGCTCGAAGCGCTCCT	0.627													1	0	5.16669e-11	0.000978	6.42489e-11	10	24										T	45671765	G	T	45671765	3	4	96	1	0	0	0	0	1	0	0	0	18241	1049	37	3	3355	3	ZSWIM5	1	45671765	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	198855	45671765	203578856	27	28503										
CYP4A11	1579	broad.mit.edu	37	chr1	47399996	47399996	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaacatgaacgtgtccacctCagcacggaggtccttgtctg	10	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:47399996C>T	uc001cqp.3	-	8	991	c.940G>A	c.(940-942)GAG>AAG	p.E314K	CYP4A11_uc001cqq.2_Missense_Mutation_p.E314K|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	314					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GTGTCCACCTCAGCACGGAGG	0.547													0	0	0	0.004656	0	16	24										T	47399996	C	T	47399996	3	4	96	1	0	0	0	0	1	0	0	0	4183	835	29	1	639	1	CYP4A11	1	47399996	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1728231	47399996	201850625	28	28504										
CYP4A22	284541	broad.mit.edu	37	chr1	47610264	47610264	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagacaaggacctccgtgctGaggtggacacgttcatgttt	12	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:47610264G>A	uc001cqv.1	+	8	991	c.940G>A	c.(940-942)GAG>AAG	p.E314K	CYP4A22_uc009vyo.2_Missense_Mutation_p.E314K|CYP4A22_uc009vyp.2_Intron	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	314						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						CCTCCGTGCTGAGGTGGACAC	0.552													0	0	0	0.003954	0	14	129										A	47610264	G	A	47610264	3	1	96	1	0	0	0	0	1	0	0	0	4184	1291	45	1	970	1	CYP4A22	1	47610264	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	210268	47610264	201640357	29	28505										
NRD1	4898	broad.mit.edu	37	chr1	52283797	52283797	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcagagcatgaatttttctGattggaacaactaaacaaaa	7	6	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:52283797G>C	uc001ctc.3	-	12	1828	c.1506C>G	c.(1504-1506)ATC>ATG	p.I502M	NRD1_uc009vzb.2_Missense_Mutation_p.I197M|NRD1_uc001ctd.3_Missense_Mutation_p.I434M|NRD1_uc001cte.2_Missense_Mutation_p.I370M|NRD1_uc001ctf.2_Missense_Mutation_p.I434M|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.I302M	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	433					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						GAATTTTTCTGATTGGAACAA	0.323													0	0	0	0.00308	0	6	31										C	52283797	G	C	52283797	3	2	96	1	0	0	0	0	1	0	0	0	10645	1280	45	1	2241	1	NRD1	1	52283797	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4673533	52283797	196966824	30	28506										
USP24	23358	broad.mit.edu	37	chr1	55595217	55595217	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcttctggccatgtcatcatCagctgttggcatgagtttgg	12	9	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:55595217C>T	uc001cyg.3	-	29	3088	c.3088G>A	c.(3088-3090)GAT>AAT	p.D1030N		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1190					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						ATGTCATCATCAGCTGTTGGC	0.398													0	0	0	0.004482	0	9	60										T	55595217	C	T	55595217	3	4	96	1	0	0	0	0	1	0	0	0	17052	826	29	1	4442	1	USP24	1	55595217	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3311420	55595217	193655404	31	28507										
RAVER2	55225	broad.mit.edu	37	chr1	65243754	65243754	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgcaaattttttccagtgtCcataaacctgtgttttgcca	6	9	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:65243754C>T	uc001dbs.1	+	3	843	c.765C>T	c.(763-765)GTC>GTT	p.V255V	RAVER2_uc001dbt.1_Silent_p.V134V|RAVER2_uc010opb.1_Silent_p.V134V	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	255	RRM 3.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						TTTCCAGTGTCCATAAACCTG	0.318													0	0	0	0.00333	0	22	49										T	65243754	C	T	65243754	2	4	96	1	0	0	0	0	0	0	0	1	13095	842	30	1		1	RAVER2	1	65243754	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9648537	65243754	184006867	32	28508										
MIER1	57708	broad.mit.edu	37	chr1	67436578	67436578	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttaaagatgcatctagaaGaacaggtgatgagaagggtg	13	4	2	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:67436578G>A	uc001dde.2	+	9	994	c.860G>A	c.(859-861)AGA>AAA	p.R287K	MIER1_uc010opf.1_Missense_Mutation_p.R251K|MIER1_uc009way.2_Missense_Mutation_p.R251K|MIER1_uc001ddc.2_Missense_Mutation_p.R287K|MIER1_uc001ddh.2_Missense_Mutation_p.R171K|MIER1_uc001ddf.2_Missense_Mutation_p.R251K|MIER1_uc001ddg.2_Missense_Mutation_p.R207K|MIER1_uc010opg.1_Missense_Mutation_p.R251K|MIER1_uc001ddj.1_Missense_Mutation_p.R234K|MIER1_uc001ddi.2_Missense_Mutation_p.R234K	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	258	ELM2.|Interaction with HDAC1.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						GCATCTAGAAGAACAGGTGAT	0.358													0	0	0	0.003163	0	16	61										A	67436578	G	A	67436578	3	1	96	1	0	0	0	0	1	0	0	0	9580	942	33	1	971	1	MIER1	1	67436578	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2192824	67436578	181814043	33	28509										
PIGK	10026	broad.mit.edu	37	chr1	77627290	77627290	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcacataccgagagtgaatCttctcccacttgactactag	7	12	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:77627290C>G	uc001dhk.2	-	7	736	c.691G>C	c.(691-693)GAT>CAT	p.D231H	PIGK_uc010orj.1_Missense_Mutation_p.D155H|PIGK_uc009wbx.2_Missense_Mutation_p.D137H|PIGK_uc001dhl.1_Missense_Mutation_p.D231H	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	231	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						GAGAGTGAATCTTCTCCCACT	0.368													0	0	0	0.00245	0	14	65										G	77627290	C	G	77627290	3	3	96	1	0	0	0	0	1	0	0	0	11890	913	32	1	516	1	PIGK	1	77627290	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10190712	77627290	171623331	34	28510										
LPHN2	23266	broad.mit.edu	37	chr1	82409390	82409390	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caagagataaccaactttacGtgtggaacaataacttcatt	6	8	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:82409390G>A	uc001dit.3	+	6	1316	c.1135G>A	c.(1135-1137)GTG>ATG	p.V379M	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.V379M|LPHN2_uc001div.2_Missense_Mutation_p.V379M|LPHN2_uc009wcd.2_Missense_Mutation_p.V379M	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	379	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CCAACTTTACGTGTGGAACAA	0.408													0	0	0	0.00278	0	24	91										A	82409390	G	A	82409390	3	1	96	1	0	0	0	0	1	0	0	0	8916	1145	40	2	1149	2	LPHN2	1	82409390	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4782100	82409390	166841231	35	28511										
RBMXL1	494115	broad.mit.edu	37	chr1	89449287	89449287	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caccttgatggcttttccatCtaatgactttccattcatgt	5	11	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:89449287C>A	uc009wcx.2	-	3	939	c.223G>T	c.(223-225)GAT>TAT	p.D75Y	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Missense_Mutation_p.D75Y	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	75	RRM.						nucleotide binding|RNA binding				0						GCTTTTCCATCTAATGACTTT	0.478											OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.48254e-18	0.00361	3.14135e-18	53	169										A	89449287	C	A	89449287	3	1	96	1	0	0	0	0	1	0	0	0	13153	913	32	3	953	3	RBMXL1	1	89449287	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7039897	89449287	159801334	36	28512										
GBP3	2635	broad.mit.edu	37	chr1	89486323	89486323	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatggcagacaggattttcaGagcttctggattcgccacca	10	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:89486323G>T	uc001dmt.2	-	2	287	c.82C>A	c.(82-84)CTG>ATG	p.L28M	GBP3_uc010oss.1_Translation_Start_Site|GBP3_uc001dmu.2_Translation_Start_Site|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	28	Helical; (Potential).					integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		AGGATTTTCAGAGCTTCTGGA	0.517													1	0	6.05902e-23	0.003755	7.72123e-23	37	106										T	89486323	G	T	89486323	3	4	96	1	0	0	0	0	1	0	0	0	6275	933	33	3	1745	3	GBP3	1	89486323	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	37036	89486323	159764298	37	28513										
TGFBR3	7049	broad.mit.edu	37	chr1	92184913	92184913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagggctgaccaccggggccGagtaccgcagccattcagag	14	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:92184913G>A	uc001doh.2	-	10	1988	c.1522C>T	c.(1522-1524)CGG>TGG	p.R508W	TGFBR3_uc009wde.2_Missense_Mutation_p.R285W|TGFBR3_uc010osy.1_Missense_Mutation_p.R466W|TGFBR3_uc001doi.2_Missense_Mutation_p.R507W|TGFBR3_uc001doj.2_Missense_Mutation_p.R507W	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	508	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		CACCGGGGCCGAGTACCGCAG	0.547													0	0	0	0.002836	0	35	62										A	92184913	G	A	92184913	3	1	96	1	0	0	0	0	1	0	0	0	15820	1057	37	1	1065	1	TGFBR3	1	92184913	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2698590	92184913	157065708	38	28514										
EVI5	7813	broad.mit.edu	37	chr1	93091443	93091443	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagtttcacagcaatgagttCttcctgaagccttgcaatat	7	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:93091443C>T	uc001dox.2	-	13	1538	c.1528G>A	c.(1528-1530)GAA>AAA	p.E510K	EVI5_uc010otf.1_Missense_Mutation_p.E521K|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	510	Targeting to the centrosomes.|Potential.|Dimerization.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GCAATGAGTTCTTCCTGAAGC	0.338													0	0	0	0.001786	0	31	46										T	93091443	C	T	93091443	3	4	96	1	0	0	0	0	1	0	0	0	5289	922	32	1	928	1	EVI5	1	93091443	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	906530	93091443	156159178	39	28515										
ARHGAP29	9411	broad.mit.edu	37	chr1	94655506	94655506	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caactttttcttcttcagttGaatttgtggccttgacaaat	6	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:94655506G>A	uc001dqj.3	-	13	1784	c.1415C>T	c.(1414-1416)TCA>TTA	p.S472L	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.S38L	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	472					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		TTCTTCAGTTGAATTTGTGGC	0.368													0	0	0	0.000978	0	12	60										A	94655506	G	A	94655506	3	1	96	1	0	0	0	0	1	0	0	0	878	1294	45	1	2414	1	ARHGAP29	1	94655506	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1564063	94655506	154595115	40	28516										
SLC30A7	148867	broad.mit.edu	37	chr1	101387384	101387384	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttcaattcttatagccattCttatagttgtaaggtaagtg	8	5	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:101387384C>G	uc001dtn.2	+	8	1016	c.829C>G	c.(829-831)CTT>GTT	p.L277V	SLC30A7_uc001dto.2_Missense_Mutation_p.L277V	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	277	Helical; (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		TATAGCCATTCTTATAGTTGT	0.303													0	0	0	0.001855	0	13	80										G	101387384	C	G	101387384	3	3	96	1	0	0	0	0	1	0	0	0	14560	913	32	1	859	1	SLC30A7	1	101387384	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6731878	101387384	147863237	41	28517										
COL11A1	1301	broad.mit.edu	37	chr1	103478004	103478004	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccagttagacccattgggcCaggtgggcctctcagagcaa	12	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:103478004C>T	uc001dul.2	-	14	1912	c.1594G>A	c.(1594-1596)GGC>AGC	p.G532S	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G544S|COL11A1_uc001dun.2_Missense_Mutation_p.G493S|COL11A1_uc009weh.2_Missense_Mutation_p.G416S	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	532	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCATTGGGCCAGGTGGGCCT	0.388													0	0	0	0.008291	0	9	24										T	103478004	C	T	103478004	3	4	96	1	0	0	0	0	1	0	0	0	3667	594	21	2	4042	2	COL11A1	1	103478004	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2090620	103478004	145772617	42	28518										
EPS8L3	79574	broad.mit.edu	37	chr1	110301959	110301959	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgtaggaacatgtgttgagCgccacattcatggcctggat	12	8	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:110301959C>T	uc001dyr.1	-	5	451	c.306G>A	c.(304-306)GCG>GCA	p.A102A	EPS8L3_uc001dys.1_Silent_p.A102A|EPS8L3_uc001dyq.1_Silent_p.A102A|EPS8L3_uc009wfm.1_Silent_p.A68A|EPS8L3_uc009wfn.1_Silent_p.A68A|EPS8L3_uc009wfo.1_Silent_p.A49A	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	102						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		ATGTGTTGAGCGCCACATTCA	0.607													0	0	0	0.00361	0	68	144										T	110301959	C	T	110301959	2	4	96	1	0	0	0	0	0	0	0	1	5197	755	27	2		2	EPS8L3	1	110301959	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6823955	110301959	138948662	43	28519										
CHIA	27159	broad.mit.edu	37	chr1	111854934	111854934	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acctgatctacgcctttgctGggaggcagaacaacgagatc	11	11	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:111854934G>A	uc001eas.2	+	4	281	c.178G>A	c.(178-180)GGG>AGG	p.G60R	CHIA_uc001ear.2_Intron|CHIA_uc001eaq.2_Intron|CHIA_uc009wgc.2_Intron|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_Intron|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	60					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		CGCCTTTGCTGGGAGGCAGAA	0.522													0	0	0	0.00245	0	14	119										A	111854934	G	A	111854934	3	1	96	1	0	0	0	0	1	0	0	0	3342	1348	47	2	188	2	CHIA	1	111854934	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1552975	111854934	137395687	44	28520										
DDX20	11218	broad.mit.edu	37	chr1	112309338	112309338	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtcatagggaaatacgtctGagtttttctgatacctatca	8	7	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:112309338G>C	uc001ebs.2	+	11	2649	c.2292G>C	c.(2290-2292)CTG>CTC	p.L764L	DDX20_uc010owf.1_Silent_p.L526L|DDX20_uc001ebt.2_Silent_p.L372L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	764					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATACGTCTGAGTTTTTCTG	0.453													0	0	0	0.001984	0	5	55										C	112309338	G	C	112309338	2	2	96	1	0	0	0	0	0	0	0	1	4348	1277	45	1		1	DDX20	1	112309338	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	454404	112309338	136941283	45	28521										
ST7L	54879	broad.mit.edu	37	chr1	113159453	113159453	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaaatattagtcctgatatCaatgaagaggtccctgtaag	8	7	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:113159453C>T	uc001ecd.2	-	2	575	c.270G>A	c.(268-270)TTG>TTA	p.L90L	ST7L_uc001ecc.2_5'UTR|ST7L_uc010owg.1_Silent_p.L90L|ST7L_uc010owh.1_Silent_p.L90L|ST7L_uc001ece.2_Silent_p.L90L|ST7L_uc001ecf.2_Silent_p.L73L|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Silent_p.L25L|ST7L_uc001ech.2_Silent_p.L73L|ST7L_uc001eci.2_Silent_p.L90L|ST7L_uc009wgi.1_Intron|ST7L_uc010owj.1_Silent_p.L73L|CAPZA1_uc001ecj.1_5'Flank	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	90	Helical; (Potential).				negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCCTGATATCAATGAAGAGG	0.264													0	0	0	0.000978	0	10	105										T	113159453	C	T	113159453	2	4	96	1	0	0	0	0	0	0	0	1	15229	825	29	1		1	ST7L	1	113159453	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	850115	113159453	136091168	46	28522										
AMPD1	270	broad.mit.edu	37	chr1	115236063	115236063	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatgcaatactcacgtttctCttcagctgtatgaagtaaaa	6	8	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:115236063C>A	uc001efe.1	-	2	112	c.28G>T	c.(28-30)GAG>TAG	p.E10*	AMPD1_uc001eff.1_Intron	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	10					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	TCACGTTTCTCTTCAGCTGTA	0.323													1	0	1.64293e-13	0.00333	2.05545e-13	22	75										A	115236063	C	A	115236063	4	1	96	1	0	0	0	0	0	1	0	0	585	922	32	3	2275	3	AMPD1	1	115236063	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2076610	115236063	134014558	47	28523										
ATP1A1	476	broad.mit.edu	37	chr1	116935566	116935566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggagatgagagaaagatacGccaaaatcgtcgagataccc	11	8	0	5	rs148719009		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:116935566G>A	uc001ege.2	+	11	1762	c.1423G>A	c.(1423-1425)GCC>ACC	p.A475T	ATP1A1_uc010owv.1_Missense_Mutation_p.A444T|ATP1A1_uc010oww.1_Missense_Mutation_p.A475T|ATP1A1_uc010owx.1_Missense_Mutation_p.A444T|C1orf203_uc009whb.2_RNA	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	475	Cytoplasmic (Potential).			A -> T (in Ref. 12; CAA27390).	ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	AGAAAGATACGCCAAAATCGT	0.537													0	0	0	0.003163	0	14	109										A	116935566	G	A	116935566	3	1	96	1	0	0	0	0	1	0	0	0	1128	1087	38	2	1481	2	ATP1A1	1	116935566	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1699503	116935566	132315055	48	28524										
NOTCH2	4853	broad.mit.edu	37	chr1	120461054	120461054	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcatccactgcattcacatcCgcttggcagttgatcagttc	7	13	3	1	rs149442704		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:120461054C>T	uc001eik.2	-	32	6160	c.5904G>A	c.(5902-5904)GCG>GCA	p.A1968A		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1968	Cytoplasmic (Potential).|ANK 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATTCACATCCGCTTGGCAGT	0.527			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.001368	0	11	104										T	120461054	C	T	120461054	2	4	96	1	0	0	0	0	0	0	0	1	10548	639	23	2		2	NOTCH2	1	120461054	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3525488	120461054	128789567	49	28525										
NBPF10	100132406	broad.mit.edu	37	chr1	145293519	145293519	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaacagcagttcagaaacctCaaagagaaatgttttctaac	6	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:145293519C>G	uc001end.3	+	1	149	c.114C>G	c.(112-114)CTC>CTG	p.L38L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Silent_p.L38L|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Silent_p.L38L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	38											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCAGAAACCTCAAAGAGAAAT	0.473													0	0	0	0.00361	0	49	568										G	145293519	C	G	145293519	2	3	96	1	0	0	0	0	0	0	0	1	10193	813	29	1		1	NBPF10	1	145293519	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	24832465	145293519	103957102	50	28526										
TXNIP	10628	broad.mit.edu	37	chr1	145440314	145440314	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctttgagaatacatgttcccGaattgtggtccccaaagctg	9	10	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:145440314G>T	uc001enn.3	+	5	961	c.620G>T	c.(619-621)CGA>CTA	p.R207L	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.R152L	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	207					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACATGTTCCCGAATTGTGGTC	0.453													1	0	1.43246e-33	0.007835	1.83193e-33	40	84										T	145440314	G	T	145440314	3	4	96	1	0	0	0	0	1	0	0	0	16800	1058	37	3	638	3	TXNIP	1	145440314	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	146795	145440314	103810307	51	28527										
ANKRD34A	284615	broad.mit.edu	37	chr1	145473774	145473774	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catcatcaccaccgatacctCgccctcaggcaccaagaaga	6	17	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:145473774C>T	uc001enq.1	+	4	1739	c.446C>T	c.(445-447)TCG>TTG	p.S149L	NBPF10_uc001emp.3_Intron	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	149											0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACCGATACCTCGCCCTCAGGC	0.652													0	0	0	0.008291	0	11	47										T	145473774	C	T	145473774	3	4	96	1	0	0	0	0	1	0	0	0	662	893	31	1	448	1	ANKRD34A	1	145473774	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	33460	145473774	103776847	52	28528										
BCL9	607	broad.mit.edu	37	chr1	147096327	147096327	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatgggcgaacaagcccccaGaatgggactagcattacctg	12	11	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:147096327G>A	uc001epq.2	+	10	4588	c.3848G>A	c.(3847-3849)AGA>AAA	p.R1283K	BCL9_uc010ozr.1_Missense_Mutation_p.R1197K	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1283	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CAAGCCCCCAGAATGGGACTA	0.587			T	IGH@|IGL@	B-ALL								0	0	0	0.004482	0	9	44										A	147096327	G	A	147096327	3	1	96	1	0	0	0	0	1	0	0	0	1381	942	33	1	3874	1	BCL9	1	147096327	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1622553	147096327	102154294	53	28529										
HIST2H2BE	8349	broad.mit.edu	37	chr1	149858021	149858021	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcatgatgcccatggccttgGacgagatgccggtgtcgggg	16	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:149858021G>A	uc001etc.2	-	1	212	c.170C>T	c.(169-171)TCC>TTC	p.S57F	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	57					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CATGGCCTTGGACGAGATGCC	0.587													0	0	0	0.00361	0	82	172										A	149858021	G	A	149858021	3	1	96	1	0	0	0	0	1	0	0	0	7179	1174	41	1	214	1	HIST2H2BE	1	149858021	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2761694	149858021	99392600	54	28530										
ANXA9	8416	broad.mit.edu	37	chr1	150960575	150960575	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacacacacaagtgtttgatCagtaccagcggagcactggg	11	10	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:150960575C>T	uc001ewa.2	+	11	1176	c.706C>T	c.(706-708)CAG>TAG	p.Q236*		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	236	Annexin 3.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTGTTTGATCAGTACCAGCG	0.557													0	0	0	0.00333	0	20	48										T	150960575	C	T	150960575	4	4	96	1	0	0	0	0	0	1	0	0	725	827	29	1	740	1	ANXA9	1	150960575	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1102554	150960575	98290046	55	28531										
ZNF687	57592	broad.mit.edu	37	chr1	151261860	151261860	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtcctcacttcaggctgatCtacaagtgcgccatgtgcga	10	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151261860C>T	uc001exq.2	+	5	2576	c.2478C>T	c.(2476-2478)ATC>ATT	p.I826I	ZNF687_uc009wmo.2_Silent_p.I826I|ZNF687_uc009wmp.2_Silent_p.I826I	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	826					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCAGGCTGATCTACAAGTGCG	0.622													0	0	0	0.002852	0	41	94										T	151261860	C	T	151261860	2	4	96	1	0	0	0	0	0	0	0	1	18089	903	32	1		1	ZNF687	1	151261860	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	301285	151261860	97988761	56	28532			1	128		6	4	1657	N	T_C	2.483233e-05
ZNF687	57592	broad.mit.edu	37	chr1	151262612	151262612	+	Missense_Mutation	SNP	C	C	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcctagtcagtgaaaaagttCccctgtcgcctgtgtgagcg							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262612C>A	uc001exq.2	+	7	3077	c.2979C>A	c.(2977-2979)TTC>TTA	p.F993L	ZNF687_uc009wmo.2_Missense_Mutation_p.F993L|ZNF687_uc009wmp.2_Missense_Mutation_p.F993L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	993	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGAAAAAGTTCCCCTGTCGCC	0.612													1	0	5.8336e-16	0.003271	7.33658e-16	14	95										A	151262612	C	A	151262612	3	1	96	1	0	0	0	0	1	0	0	0	18089	854	30	3	3001	3	ZNF687	1	151262612	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	752	151262612	97988009	57	28533	142	2	1	128		6	4	1657	N	T_C	2.483233e-05
ZNF687	57592	broad.mit.edu	37	chr1	151262619	151262619	+	Missense_Mutation	SNP	C	C	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtgaaaaagttcccctgtCgcctgtgtgagcgctccttc							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262619C>A	uc001exq.2	+	7	3084	c.2986C>A	c.(2986-2988)CGC>AGC	p.R996S	ZNF687_uc009wmo.2_Missense_Mutation_p.R996S|ZNF687_uc009wmp.2_Missense_Mutation_p.R996S	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	996	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTTCCCCTGTCGCCTGTGTGA	0.592													1	0	1.90571e-15	0.004289	2.39461e-15	13	94										A	151262619	C	A	151262619	3	1	96	1	0	0	0	0	1	0	0	0	18089	884	31	3	3008	3	ZNF687	1	151262619	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7	151262619	97988002	58	28534	142	2	1	128		6	4	1657	N	T_C	2.483233e-05
ZNF687	57592	broad.mit.edu	37	chr1	151262635	151262635	+	Missense_Mutation	SNP	C	C	T													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgtcgcctgtgtgagcgctCcttctgctccgcccccagcc							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262635C>T	uc001exq.2	+	7	3100	c.3002C>T	c.(3001-3003)TCC>TTC	p.S1001F	ZNF687_uc009wmo.2_Missense_Mutation_p.S1001F|ZNF687_uc009wmp.2_Missense_Mutation_p.S1001F	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1001	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGTGAGCGCTCCTTCTGCTCC	0.597													0	0	0	0.003271	0	13	95										T	151262635	C	T	151262635	3	4	96	1	0	0	0	0	1	0	0	0	18089	855	30	1	3024	1	ZNF687	1	151262635	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	16	151262635	97987986	59	28535	143	2	1	128		6	4	1657	N	T_C	2.483233e-05
ZNF687	57592	broad.mit.edu	37	chr1	151262637	151262637	+	Missense_Mutation	SNP	T	T	C													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcgcctgtgtgagcgctccTtctgctccgcccccagcctg							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151262637T>C	uc001exq.2	+	7	3102	c.3004T>C	c.(3004-3006)TTC>CTC	p.F1002L	ZNF687_uc009wmo.2_Missense_Mutation_p.F1002L|ZNF687_uc009wmp.2_Missense_Mutation_p.F1002L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1002	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGAGCGCTCCTTCTGCTCCGC	0.592													0	0	0	0.003755	0	13	96										C	151262637	T	C	151262637	3	2	96	1	0	0	0	0	1	0	0	0	18089	1609	56	5	3026	5	ZNF687	1	151262637	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	2	151262637	97987984	60	28536	143	2	1	128		6	4	1657	N	T_C	2.483233e-05
ZNF687	57592	broad.mit.edu	37	chr1	151263516	151263516	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaggaagaggcccctccatCaaggtctgaccccgatggtg	14	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:151263516C>G	uc001exq.2	+	9	3643	c.3545C>G	c.(3544-3546)TCA>TGA	p.S1182*	ZNF687_uc009wmo.2_Nonsense_Mutation_p.S1182*|ZNF687_uc009wmp.2_3'UTR	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	1182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCCCCTCCATCAAGGTCTGAC	0.617													0	0	0	0.003954	0	24	59										G	151263516	C	G	151263516	4	3	96	1	0	0	0	0	0	1	0	0	18089	838	29	1	3575	1	ZNF687	1	151263516	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	879	151263516	97987105	61	28537			1	128		6	4	1657	N	T_C	2.483233e-05
TCHHL1	126637	broad.mit.edu	37	chr1	152058710	152058710	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgctgcaggtgcgtttttgCtgttcacaaatgcttctgct	10	10	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:152058710C>T	uc001ezo.1	-	3	1513	c.1448G>A	c.(1447-1449)AGC>AAC	p.S483N		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	483							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGCGTTTTTGCTGTTCACAAA	0.483													0	0	0	0.00361	0	98	225										T	152058710	C	T	152058710	3	4	96	1	0	0	0	0	1	0	0	0	15698	797	28	2	1270	2	TCHHL1	1	152058710	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	795194	152058710	97191911	62	28538										
LCE2B	26239	broad.mit.edu	37	chr1	152659594	152659594	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaccagagccccgactgctGtgagagtgaaccttctgggg	14	12	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:152659594G>C	uc001fai.2	+	2	329	c.275G>C	c.(274-276)TGT>TCT	p.C92S		NM_014357	NP_055172	O14633	LCE2B_HUMAN	late cornified envelope 2B	92	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGACTGCTGTGAGAGTGAA	0.632													0	0	0	0.003271	0	35	108										C	152659594	G	C	152659594	3	2	96	1	0	0	0	0	1	0	0	0	8666	1377	48	4	277	4	LCE2B	1	152659594	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	600884	152659594	96591027	63	28539										
ADAR	103	broad.mit.edu	37	chr1	154574803	154574803	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaaggatgctggaaccctctCtggagcccctgacttctgag	12	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:154574803C>G	uc001ffh.2	-	2	515	c.315G>C	c.(313-315)CAG>CAC	p.Q105H	ADAR_uc001ffj.2_Missense_Mutation_p.Q105H|ADAR_uc001ffi.2_Missense_Mutation_p.Q105H|ADAR_uc001ffk.2_5'UTR|ADAR_uc001ffl.1_5'UTR|ADAR_uc001ffm.1_Intron|ADAR_uc001ffn.1_Intron	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	105					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GGAACCCTCTCTGGAGCCCCT	0.557													0	0	0	0.002836	0	34	61										G	154574803	C	G	154574803	3	3	96	1	0	0	0	0	1	0	0	0	281	912	32	1	3421	1	ADAR	1	154574803	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1915209	154574803	94675818	64	28540										
RAG1AP1	55974	broad.mit.edu	37	chr1	155109406	155109406	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accctgtatatcttggcataTctgcattactgccctcggaa	7	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:155109406T>C	uc001fhj.3	+	3	361	c.261T>C	c.(259-261)TAT>TAC	p.Y87Y	RAG1AP1_uc010pey.1_RNA|RAG1AP1_uc001fhk.3_Intron|RAG1AP1_uc001fhl.3_Silent_p.Y87Y	NM_018845	NP_061333	Q9BRV3	SWET1_HUMAN	recombination activating gene 1 activating	87	Helical; Name=3; (Potential).|MtN3/slv 1.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCTTGGCATATCTGCATTACT	0.562													0	0	0	0.000602	0	5	78										C	155109406	T	C	155109406	2	2	96	1	0	0	0	0	0	0	0	1	13004	1442	50	5		5	RAG1AP1	1	155109406	Silent	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	534603	155109406	94141215	65	28541										
ASH1L	55870	broad.mit.edu	37	chr1	155313492	155313492	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgacggaccgggtggccatCaggggtgcgccgactatccc	15	14	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:155313492C>T	uc009wqq.2	-	23	8518	c.8038G>A	c.(8038-8040)GAT>AAT	p.D2680N	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2675N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2680	BAH.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GGGTGGCCATCAGGGGTGCGC	0.438													0	0	0	0.001984	0	7	64										T	155313492	C	T	155313492	3	4	96	1	0	0	0	0	1	0	0	0	1041	826	29	1	895	1	ASH1L	1	155313492	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	204086	155313492	93937129	66	28542										
GON4L	54856	broad.mit.edu	37	chr1	155796774	155796774	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttttgcagattggctgcctGatggcagggaaggtatctcc	14	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:155796774G>A	uc001flz.2	-	3	648	c.551C>T	c.(550-552)TCA>TTA	p.S184L	GON4L_uc001fly.1_Missense_Mutation_p.S184L|GON4L_uc009wrh.1_Missense_Mutation_p.S184L|GON4L_uc001fma.1_Missense_Mutation_p.S184L|GON4L_uc001fmc.2_Missense_Mutation_p.S184L|GON4L_uc001fmd.3_Missense_Mutation_p.S184L|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.S12L	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	184					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTGGCTGCCTGATGGCAGGGA	0.473													0	0	0	0.001855	0	13	72										A	155796774	G	A	155796774	3	1	96	1	0	0	0	0	1	0	0	0	6572	1294	45	1	6408	1	GON4L	1	155796774	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	483282	155796774	93453847	67	28543										
SEMA4A	64218	broad.mit.edu	37	chr1	156126258	156126258	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaagggcctccaggattttGacactctgctcctgagtggt	12	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:156126258G>C	uc001fnl.2	+	3	297	c.193G>C	c.(193-195)GAC>CAC	p.D65H	SEMA4A_uc009wrq.2_Missense_Mutation_p.D65H|SEMA4A_uc001fnm.2_Missense_Mutation_p.D65H|SEMA4A_uc001fnn.2_5'UTR|SEMA4A_uc001fno.2_Missense_Mutation_p.D65H	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	65	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCAGGATTTTGACACTCTGCT	0.542													0	0	0	0.008361	0	28	60										C	156126258	G	C	156126258	3	2	96	1	0	0	0	0	1	0	0	0	14031	1290	45	1	199	1	SEMA4A	1	156126258	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	329484	156126258	93124363	68	28544										
BCAN	63827	broad.mit.edu	37	chr1	156617443	156617443	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgggggctatgagcaatgtGatgctggctggctgtcggat	17	6	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:156617443G>C	uc001fpp.2	+	4	946	c.610G>C	c.(610-612)GAT>CAT	p.D204H	BCAN_uc001fpo.2_Missense_Mutation_p.D204H	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	204	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGAGCAATGTGATGCTGGCTG	0.647													0	0	0	0.007413	0	17	122										C	156617443	G	C	156617443	3	2	96	1	0	0	0	0	1	0	0	0	1345	1290	45	1	620	1	BCAN	1	156617443	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	491185	156617443	92633178	69	28545										
ARHGEF11	9826	broad.mit.edu	37	chr1	156912573	156912573	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatgaagaaggcccgtttatCtgtgtgaggaaaggaaggta	15	4	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:156912573C>G	uc001fqo.2	-	32	4156	c.3116_splice	c.e32-1	p.D1039_splice	ARHGEF11_uc010phu.1_Splice_Site_p.D455_splice|ARHGEF11_uc001fqn.2_Splice_Site_p.D1079_splice	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11						actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCCGTTTATCTGTGTGAGGA	0.542													0	0	0	0.006999	0	38	54										G	156912573	C	G	156912573	5	3	96	1	0	0	0	0	0	0	1	0	896	927	32	1	1489	1	ARHGEF11	1	156912573	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	295130	156912573	92338048	70	28546										
FCRL5	83416	broad.mit.edu	37	chr1	157514314	157514314	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggctggaaggagctggctctCagcactggacgtgtaaatgg	16	8	1	0	rs112294248		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:157514314C>T	uc001fqu.2	-	5	740	c.582G>A	c.(580-582)CTG>CTA	p.L194L	FCRL5_uc009wsm.2_Silent_p.L194L|FCRL5_uc010phv.1_Silent_p.L194L|FCRL5_uc010phw.1_Silent_p.L109L|FCRL5_uc001fqv.1_Silent_p.L194L|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	194	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGCTGGCTCTCAGCACTGGAC	0.557													0	0	0	0.00623	0	35	71										T	157514314	C	T	157514314	2	4	96	1	0	0	0	0	0	0	0	1	5798	813	29	1		1	FCRL5	1	157514314	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	601741	157514314	91736307	71	28547										
OR10J3	441911	broad.mit.edu	37	chr1	159284102	159284102	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggtcatatcccatgactgtGagcaggaagcagttgttgat	12	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:159284102G>A	uc010piu.1	-	1	348	c.348C>T	c.(346-348)CTC>CTT	p.L116L		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					CCATGACTGTGAGCAGGAAGC	0.507													0	0	0	0.004007	0	15	79										A	159284102	G	A	159284102	2	1	96	1	0	0	0	0	0	0	0	1	10911	1277	45	1		1	OR10J3	1	159284102	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1769788	159284102	89966519	72	28548										
ATP1A4	480	broad.mit.edu	37	chr1	160136489	160136489	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtttgatatgaccgtgtatGaggccgacaccactgaagaa	12	8	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:160136489G>T	uc001fve.3	+	8	1698	c.1219G>T	c.(1219-1221)GAG>TAG	p.E407*	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_5'UTR	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	407	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GACCGTGTATGAGGCCGACAC	0.552													1	0	1.76689e-08	0.006214	2.15438e-08	10	71										T	160136489	G	T	160136489	4	4	96	1	0	0	0	0	0	1	0	0	1131	1291	45	3	1249	3	ATP1A4	1	160136489	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	852387	160136489	89114132	73	28549										
PVRL4	81607	broad.mit.edu	37	chr1	161046192	161046192	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcccttcactcaggcacttGagcatagctccttctctgcc	7	16	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:161046192G>C	uc001fxo.2	-	4	1103	c.804C>G	c.(802-804)CTC>CTG	p.L268L	PVRL4_uc010pjy.1_5'Flank|PVRL4_uc010pjz.1_Silent_p.L2L	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	268	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TCAGGCACTTGAGCATAGCTC	0.562													0	0	0	0.004482	0	9	49										C	161046192	G	C	161046192	2	2	96	1	0	0	0	0	0	0	0	1	12842	1277	45	1		1	PVRL4	1	161046192	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	909703	161046192	88204429	74	28550										
UHMK1	127933	broad.mit.edu	37	chr1	162468057	162468057	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgcagggtcacagaaacatCggtaattgccgctgtctcct	10	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:162468057C>T	uc001gcc.1	+	1	403	c.267C>T	c.(265-267)ATC>ATT	p.I89I	UHMK1_uc001gcb.1_Intron|UHMK1_uc009wuu.1_Silent_p.I89I	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin	89	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			ACAGAAACATCGGTAATTGCC	0.607													0	0	0	0.001168	0	4	22										T	162468057	C	T	162468057	2	4	96	1	0	0	0	0	0	0	0	1	16963	898	31	1		1	UHMK1	1	162468057	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1421865	162468057	86782564	75	28551										
FAM78B	149297	broad.mit.edu	37	chr1	166039523	166039523	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtggcccccgcttgggcctCcacatgaggacctgggcatc	14	15	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:166039523C>T	uc001gdr.2	-	3	1331	c.741G>A	c.(739-741)TGG>TGA	p.W247*	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	247										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					GCTTGGGCCTCCACATGAGGA	0.592													0	0	0	0.00333	0	24	106										T	166039523	C	T	166039523	4	4	96	1	0	0	0	0	0	1	0	0	5627	856	30	1	48	1	FAM78B	1	166039523	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3571466	166039523	83211098	76	28552										
TADA1	117143	broad.mit.edu	37	chr1	166845422	166845422	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacgttgtcccccagggcctCgcttaagttcttcttggccg	10	15	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:166845422C>A	uc001gdw.2	-	1	233	c.49G>T	c.(49-51)GAG>TAG	p.E17*	TADA1_uc009wve.2_Nonsense_Mutation_p.E17*	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	17					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1						CCCAGGGCCTCGCTTAAGTTC	0.667													1	0	2.74318e-10	0.006214	3.39654e-10	9	47										A	166845422	C	A	166845422	4	1	96	1	0	0	0	0	0	1	0	0	15506	893	31	3	990	3	TADA1	1	166845422	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	805899	166845422	82405199	77	28553										
ADCY10	55811	broad.mit.edu	37	chr1	167871010	167871010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taatgtttttcagctgctttCgctccaccctccacagggct	7	14	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:167871010C>T	uc001ger.2	-	5	624	c.326G>A	c.(325-327)CGA>CAA	p.R109Q	ADCY10_uc009wvk.2_Missense_Mutation_p.R17Q|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Missense_Mutation_p.R108Q|ADCY10_uc009wvm.2_Intron	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	109	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CAGCTGCTTTCGCTCCACCCT	0.493													0	0	0	0.004656	0	26	140										T	167871010	C	T	167871010	3	4	96	1	0	0	0	0	1	0	0	0	293	884	31	1	4622	1	ADCY10	1	167871010	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1025588	167871010	81379611	78	28554										
GPR161	23432	broad.mit.edu	37	chr1	168054780	168054780	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgaggccctcatctctgctCggcagctaaaacatctcctt	7	15	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:168054780C>T	uc001gfc.2	-	8	1893	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	GPR161_uc001gfb.2_Missense_Mutation_p.E395K|GPR161_uc010pll.1_Missense_Mutation_p.E437K|GPR161_uc010plm.1_Missense_Mutation_p.E413K|GPR161_uc009wvo.2_Missense_Mutation_p.E544K|GPR161_uc001gfd.2_Missense_Mutation_p.E527K|GPR161_uc010pln.1_Missense_Mutation_p.E547K	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	527	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					CATCTCTGCTCGGCAGCTAAA	0.667													0	0	0	0.004007	0	17	81										T	168054780	C	T	168054780	3	4	96	1	0	0	0	0	1	0	0	0	6665	893	31	1	14	1	GPR161	1	168054780	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	183770	168054780	81195841	79	28555										
FMO1	2326	broad.mit.edu	37	chr1	171251468	171251468	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggtgggctgttcgagtcctGaaaggtaagtataagaaata	13	5	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:171251468G>C	uc009wvz.2	+	7	1315	c.1179G>C	c.(1177-1179)CTG>CTC	p.L393L	FMO1_uc010pme.1_Silent_p.L330L|FMO1_uc001ghl.2_Silent_p.L393L|FMO1_uc001ghm.2_Silent_p.L393L|FMO1_uc001ghn.2_Silent_p.L393L	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	393					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCGAGTCCTGAAAGGTAAGT	0.448													0	0	0	0.001984	0	7	51										C	171251468	G	C	171251468	2	2	96	1	0	0	0	0	0	0	0	1	5954	1277	45	1		1	FMO1	1	171251468	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3196688	171251468	77999153	80	28556										
ACBD6	84320	broad.mit.edu	37	chr1	180283851	180283851	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgtagagctgtttggccttCattgtcctataaaagaaaca	8	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:180283851C>G	uc001gog.2	-	7	1291	c.670G>C	c.(670-672)GAA>CAA	p.E224Q		NM_032360	NP_115736	Q9BR61	ACBD6_HUMAN	acyl-coenzyme A binding domain containing 6	224	ANK 2.					cytoplasm|nucleus	fatty-acyl-CoA binding			ovary(1)	1						GTTTGGCCTTCATTGTCCTAT	0.239													0	0	0	0.000978	0	11	77										G	180283851	C	G	180283851	3	3	96	1	0	0	0	0	1	0	0	0	126	835	29	1	186	1	ACBD6	1	180283851	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9032383	180283851	68966770	81	28557										
C1orf14	81626	broad.mit.edu	37	chr1	182921966	182921966	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggggcaggggctgcgcctcCtcttcatcctcaggcactgg	15	14	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:182921966C>G	uc001gpu.2	-	1	588	c.303G>C	c.(301-303)GAG>GAC	p.E101D	C1orf14_uc001gpv.2_5'UTR|C1orf14_uc010pnz.1_5'UTR|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	173											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		GCTGCGCCTCCTCTTCATCCT	0.602													0	0	0	0.000978	0	9	22										G	182921966	C	G	182921966	3	3	96	1	0	0	0	0	1	0	0	0	2000	680	24	4	1698	4	C1orf14	1	182921966	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2638115	182921966	66328655	82	28558										
TPR	7175	broad.mit.edu	37	chr1	186322927	186322927	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagtttctgatttctctcatGaagtgatgttatttctcgac	8	7	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:186322927G>A	uc001grv.2	-	18	2524	c.2227C>T	c.(2227-2229)CAT>TAT	p.H743Y		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	743	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTCTCTCATGAAGTGATGTT	0.353			T	NTRK1	papillary thyroid								0	0	0	0.001368	0	13	98										A	186322927	G	A	186322927	3	1	96	1	0	0	0	0	1	0	0	0	16413	1290	45	1	5000	1	TPR	1	186322927	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3400961	186322927	62927694	83	28559										
KCNT2	343450	broad.mit.edu	37	chr1	196251455	196251455	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccagtcccaacagaagtctcGtgatagaaatcatataatcc	6	11	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:196251455G>C	uc001gtd.1	-	24	2789	c.2729C>G	c.(2728-2730)ACG>AGG	p.T910R	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.T836R|KCNT2_uc001gtf.1_Missense_Mutation_p.T886R|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.T886R|KCNT2_uc001gth.1_Missense_Mutation_p.T407R	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	910	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CAGAAGTCTCGTGATAGAAAT	0.303													0	0	0	0.00308	0	6	52										C	196251455	G	C	196251455	3	2	96	1	0	0	0	0	1	0	0	0	8092	1145	40	4	698	4	KCNT2	1	196251455	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9928528	196251455	52999166	84	28560										
CFHR1	3078	broad.mit.edu	37	chr1	196797272	196797272	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagatgagtaaatatccatCtggtgagagagtacgttatg	11	5	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:196797272C>T	uc001gtn.2	+	4	617	c.503C>T	c.(502-504)TCT>TTT	p.S168F	CFHR1_uc001gtm.2_Missense_Mutation_p.S72F	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	168	Sushi 3.				complement activation	extracellular space					0						AAATATCCATCTGGTGAGAGA	0.413													0	0	0	0.006122	0	17	26										T	196797272	C	T	196797272	3	4	96	1	0	0	0	0	1	0	0	0	3284	913	32	1	517	1	CFHR1	1	196797272	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	545817	196797272	52453349	85	28561										
DDX59	83479	broad.mit.edu	37	chr1	200617569	200617569	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acatataaagctccttacctGatggacatactcatccatac	4	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:200617569G>C	uc009wzk.2	-	7	1837	c.1594C>G	c.(1594-1596)CAG>GAG	p.Q532E	DDX59_uc010ppl.1_Missense_Mutation_p.Q532E	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	532	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CTCCTTACCTGATGGACATAC	0.398													0	0	0	0.00632	0	26	54										C	200617569	G	C	200617569	3	2	96	1	0	0	0	0	1	0	0	0	4376	1299	45	1	273	1	DDX59	1	200617569	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3820297	200617569	48633052	86	28562										
KIF21B	23046	broad.mit.edu	37	chr1	200967564	200967564	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtgtgtctcggatcttgttCtgcagcagaatcagcttttc	10	9	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:200967564C>G	uc001gvs.1	-	14	2342	c.2025G>C	c.(2023-2025)CAG>CAC	p.Q675H	KIF21B_uc001gvr.1_Missense_Mutation_p.Q675H|KIF21B_uc009wzl.1_Missense_Mutation_p.Q675H|KIF21B_uc010ppn.1_Missense_Mutation_p.Q675H	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	675	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGATCTTGTTCTGCAGCAGAA	0.582													0	0	0	0.001786	0	28	130										G	200967564	C	G	200967564	3	3	96	1	0	0	0	0	1	0	0	0	8289	912	32	1	2933	1	KIF21B	1	200967564	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	349995	200967564	48283057	87	28563										
ELF3	1999	broad.mit.edu	37	chr1	201981484	201981484	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttgtcagcttccagctcttCtgatgagctcagttggatca	9	11	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:201981484C>T	uc001gxg.3	+	3	3590	c.398C>T	c.(397-399)TCT>TTT	p.S133F	ELF3_uc001gxi.3_Missense_Mutation_p.S133F|ELF3_uc001gxh.3_Missense_Mutation_p.S133F	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	133					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						TCCAGCTCTTCTGATGAGCTC	0.582													0	0	0	0.004656	0	24	132										T	201981484	C	T	201981484	3	4	96	1	0	0	0	0	1	0	0	0	5055	913	32	1	408	1	ELF3	1	201981484	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1013920	201981484	47269137	88	28564										
ELF3	1999	broad.mit.edu	37	chr1	201981809	201981809	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggagctgctggacgacggtCagcaagccagcccctaccac	12	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:201981809C>T	uc001gxg.3	+	4	3712	c.520C>T	c.(520-522)CAG>TAG	p.Q174*	ELF3_uc001gxi.3_Nonsense_Mutation_p.Q174*|ELF3_uc001gxh.3_Nonsense_Mutation_p.Q174*	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	174					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GGACGACGGTCAGCAAGCCAG	0.667													0	0	0	0.004007	0	16	77										T	201981809	C	T	201981809	4	4	96	1	0	0	0	0	0	1	0	0	5055	827	29	1	534	1	ELF3	1	201981809	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	325	201981809	47268812	89	28565										
LAX1	54900	broad.mit.edu	37	chr1	203734754	203734754	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaccttggagtccagcactCtgcatgtgactccccgcagc	11	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:203734754C>G	uc001haa.2	+	1	471	c.61C>G	c.(61-63)CTG>GTG	p.L21V	LAX1_uc010pql.1_Intron	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	21	Extracellular (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTCCAGCACTCTGCATGTGAC	0.557													0	0	0	0.001984	0	6	36										G	203734754	C	G	203734754	3	3	96	1	0	0	0	0	1	0	0	0	8648	912	32	1	108	1	LAX1	1	203734754	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1752945	203734754	45515867	90	28566										
PIK3C2B	5287	broad.mit.edu	37	chr1	204438482	204438482	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggggatagtttcttgcaaGagccctctatgtcccctggt	12	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:204438482G>C	uc001haw.2	-	3	928	c.449C>G	c.(448-450)TCT>TGT	p.S150C	PIK3C2B_uc010pqv.1_Missense_Mutation_p.S150C|PIK3C2B_uc001hax.1_Missense_Mutation_p.S150C|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	150	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TTTCTTGCAAGAGCCCTCTAT	0.577													0	0	0	0.001168	0	6	68										C	204438482	G	C	204438482	3	2	96	1	0	0	0	0	1	0	0	0	11910	942	33	1	4583	1	PIK3C2B	1	204438482	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	703728	204438482	44812139	91	28567										
NFASC	23114	broad.mit.edu	37	chr1	204942505	204942505	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accagtgcaacacctccaacGagcatggctacctgctggcc	9	16	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:204942505G>A	uc001hbj.2	+	12	1565	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	NFASC_uc001hbh.2_Missense_Mutation_p.E413K|NFASC_uc010pqz.1_Missense_Mutation_p.E407K|NFASC_uc010pra.1_Missense_Mutation_p.E424K|NFASC_uc001hbi.2_Missense_Mutation_p.E424K|NFASC_uc009xbg.1_Missense_Mutation_p.E497K|NFASC_uc010prb.1_Missense_Mutation_p.E424K|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_Missense_Mutation_p.E234K	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	413	Extracellular (Potential).|Ig-like C2-type 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CACCTCCAACGAGCATGGCTA	0.607													0	0	0	0.004007	0	16	37										A	204942505	G	A	204942505	3	1	96	1	0	0	0	0	1	0	0	0	10359	1059	37	1	1330	1	NFASC	1	204942505	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	504023	204942505	44308116	92	28568										
ELK4	2005	broad.mit.edu	37	chr1	205589767	205589767	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtatgtagtcattgcggctaGaggtcttggcaccaggctga	14	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:205589767G>T	uc001hcy.1	-	3	1657	c.407C>A	c.(406-408)TCT>TAT	p.S136Y	ELK4_uc001hcz.2_Missense_Mutation_p.S136Y	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	136						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			ATTGCGGCTAGAGGTCTTGGC	0.418			T	SLC45A3	prostate								1	0	2.74318e-10	0.006214	3.39654e-10	10	107										T	205589767	G	T	205589767	3	4	96	1	0	0	0	0	1	0	0	0	5061	942	33	3	1038	3	ELK4	1	205589767	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	647262	205589767	43660854	93	28569										
SLC45A3	85414	broad.mit.edu	37	chr1	205628644	205628644	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcacaggcagaggccccgcaGagcgcgggtggaggtgggag	20	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:205628644G>C	uc001hda.1	-	5	1719	c.1380C>G	c.(1378-1380)CTC>CTG	p.L460L	SLC45A3_uc010prn.1_Intron|SLC45A3_uc010pro.1_Intron|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	460					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AGGCCCCGCAGAGCGCGGGTG	0.677			T	ETV1|ETV5|ELK4|ERG	prostate 						OREG0014161	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	24										C	205628644	G	C	205628644	2	2	96	1	0	0	0	0	0	0	0	1	14642	929	33	1		1	SLC45A3	1	205628644	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	38877	205628644	43621977	94	28570										
SLC26A9	115019	broad.mit.edu	37	chr1	205892252	205892252	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcctctgttgtgtgggcctCattctccgcttctcctgctt	8	15	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:205892252C>T	uc001hdq.2	-	16	1845	c.1731G>A	c.(1729-1731)ATG>ATA	p.M577I	SLC26A9_uc001hdo.2_Missense_Mutation_p.M245I|SLC26A9_uc001hdp.2_Missense_Mutation_p.M577I	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	577	STAS.					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GTGTGGGCCTCATTCTCCGCT	0.522													0	0	0	0.003954	0	23	101										T	205892252	C	T	205892252	3	4	96	1	0	0	0	0	1	0	0	0	14524	826	29	1	964	1	SLC26A9	1	205892252	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	263608	205892252	43358369	95	28571										
IKBKE	9641	broad.mit.edu	37	chr1	206652436	206652436	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaagcagccccctgaccctCttcagcacagccatccctaa	6	19	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:206652436C>G	uc001hdz.1	+	10	1511	c.1143C>G	c.(1141-1143)CTC>CTG	p.L381L	IKBKE_uc009xbv.1_Silent_p.L381L|IKBKE_uc001hea.1_Silent_p.L296L	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	381					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					CCCTGACCCTCTTCAGCACAG	0.607													0	0	0	0.004007	0	17	43										G	206652436	C	G	206652436	2	3	96	1	0	0	0	0	0	0	0	1	7612	900	32	1		1	IKBKE	1	206652436	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	760184	206652436	42598185	96	28572										
LGTN	1939	broad.mit.edu	37	chr1	206772966	206772966	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtatgacgaaagatgtaatCctaaaacccagcagaaggaa	10	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:206772966C>T	uc001heh.2	-	10	1262	c.1053G>A	c.(1051-1053)AGG>AGA	p.R351R	LGTN_uc009xbw.2_Silent_p.R227R	NM_006893	NP_008824	P41214	EIF2D_HUMAN	ligatin	351					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			AAGATGTAATCCTAAAACCCA	0.532													0	0	0	0.00245	0	13	76										T	206772966	C	T	206772966	2	4	96	1	0	0	0	0	0	0	0	1	8760	869	30	1		1	LGTN	1	206772966	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	120530	206772966	42477655	97	28573										
IRF6	3664	broad.mit.edu	37	chr1	209974644	209974644	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccgggtggcatgtttccaggGaatctggaagcgtttagagt	15	7	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:209974644G>C	uc001hhq.1	-	3	378	c.115C>G	c.(115-117)CCC>GCC	p.P39A	IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Missense_Mutation_p.P39A	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	39	IRF tryptophan pentad repeat.		P -> A (in VWS).		cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TGTTTCCAGGGAATCTGGAAG	0.512										HNSCC(57;0.16)			0	0	0	0.004007	0	15	120										C	209974644	G	C	209974644	3	2	96	1	0	0	0	0	1	0	0	0	7834	1174	41	1	1316	1	IRF6	1	209974644	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3201678	209974644	39275977	98	28574										
IRF6	3664	broad.mit.edu	37	chr1	209974759	209974759	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgcgggggtggagggccatGatctgggggggtcagaggga	23	6	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:209974759G>C	uc001hhq.1	-	3	263	c.0C>G	c.(-2-2)ATCAT>ATGAT		IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Translation_Start_Site	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6						cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		GGAGGGCCATGATCTGGGGGG	0.592										HNSCC(57;0.16)			0	0	0	0.008291	0	9	98										C	209974759	G	C	209974759	1	2	96	1	0	0	0	0	0	0	0	0	7834	1305	45	1		1	IRF6	1	209974759	Translation_Start_Site	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	115	209974759	39275862	99	28575										
SMYD2	56950	broad.mit.edu	37	chr1	214505378	214505378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caccccctagtgagctgctgGagatctgcgagctcagccag	12	14	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:214505378G>A	uc010ptx.1	+	10	988	c.955G>A	c.(955-957)GAG>AAG	p.E319K	SMYD2_uc009xdj.2_3'UTR|SMYD2_uc010ptw.1_RNA|SMYD2_uc009xdl.1_Intron	NM_020197	NP_064582	Q9NRG4	SMYD2_HUMAN	SET and MYND domain containing 2	319					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	cytosol|nucleus	histone methyltransferase activity (H3-K36 specific)|p53 binding|RNA polymerase II core binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0122)|all cancers(67;0.0209)|GBM - Glioblastoma multiforme(131;0.106)|Epithelial(68;0.144)		TGAGCTGCTGGAGATCTGCGA	0.562											OREG0012979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	38										A	214505378	G	A	214505378	3	1	96	1	0	0	0	0	1	0	0	0	14822	1175	41	1	993	1	SMYD2	1	214505378	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4530619	214505378	34745243	100	28576										
DUSP10	11221	broad.mit.edu	37	chr1	221876002	221876002	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggatgagaagccccttccCacactggtgagcttcctctg	11	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:221876002C>G	uc001hmy.1	-	4	1383	c.1201G>C	c.(1201-1203)GGG>CGG	p.G401R	DUSP10_uc001hmx.1_Missense_Mutation_p.G59R|DUSP10_uc001hmz.1_Missense_Mutation_p.G59R	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	401	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		AGCCCCTTCCCACACTGGTGA	0.522													0	0	0	0.003163	0	14	42										G	221876002	C	G	221876002	3	3	96	1	0	0	0	0	1	0	0	0	4810	594	21	4	251	4	DUSP10	1	221876002	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7370624	221876002	27374619	101	28577										
MIA3	375056	broad.mit.edu	37	chr1	222826446	222826446	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaaagatttggaagtagctCttactcacaaggatgataat	9	5	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:222826446C>T	uc001hnl.2	+	14	4192	c.4183C>T	c.(4183-4185)CTT>TTT	p.L1395F	MIA3_uc009xea.1_Missense_Mutation_p.L1172F|MIA3_uc001hnm.2_Missense_Mutation_p.L273F	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1395	Potential.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GGAAGTAGCTCTTACTCACAA	0.348													0	0	0	0.000248	0	4	48										T	222826446	C	T	222826446	3	4	96	1	0	0	0	0	1	0	0	0	9565	913	32	1	4237	1	MIA3	1	222826446	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	950444	222826446	26424175	102	28578										
CABC1	56997	broad.mit.edu	37	chr1	227149128	227149128	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accatcatggtggctaaaggCcttgtcaagctgacccaggc	11	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:227149128C>T	uc001hqm.1	+	7	3461	c.42C>T	c.(40-42)GGC>GGT	p.G14G	CABC1_uc010pvp.1_5'UTR|CABC1_uc001hqn.1_Silent_p.G14G|CABC1_uc009xeq.1_Intron|CABC1_uc010pvq.1_Intron	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	14					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				TGGCTAAAGGCCTTGTCAAGC	0.642													0	0	0	0.001168	0	6	92										T	227149128	C	T	227149128	2	4	96	1	0	0	0	0	0	0	0	1	2527	726	26	2		2	CABC1	1	227149128	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4322682	227149128	22101493	103	28579										
SNAP47	116841	broad.mit.edu	37	chr1	227923158	227923158	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcgcaggcgccgagcggccGaggcgccgcggtcggctctg	19	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:227923158G>A	uc001hrf.2	+	1	462	c.48G>A	c.(46-48)CCG>CCA	p.P16P	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Silent_p.P16P|SNAP47_uc001hre.2_5'UTR|JMJD4_uc001hrc.2_5'Flank|JMJD4_uc001hrb.2_5'Flank	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	16						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						CCGAGCGGCCGAGGCGCCGCG	0.761													0	0	0	0.004672	0	3	5										A	227923158	G	A	227923158	2	1	96	1	0	0	0	0	0	0	0	1	14832	1045	37	1		1	SNAP47	1	227923158	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	774030	227923158	21327463	104	28580										
C1orf35	79169	broad.mit.edu	37	chr1	228290054	228290054	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggcggcctccttgtcctctCgggacatcgccacgcggccc	12	18	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:228290054C>G	uc001hrx.2	-	5	498	c.404G>C	c.(403-405)CGA>CCA	p.R135P	C1orf35_uc009xew.2_RNA	NM_024319	NP_077295	Q9BU76	MMTA2_HUMAN	hypothetical protein LOC79169	135											0		Prostate(94;0.0488)				CTTGTCCTCTCGGGACATCGC	0.692													0	0	0	0.000602	0	4	18										G	228290054	C	G	228290054	3	3	96	1	0	0	0	0	1	0	0	0	2038	884	31	1	403	1	C1orf35	1	228290054	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	366896	228290054	20960567	105	28581										
PCNXL2	80003	broad.mit.edu	37	chr1	233314877	233314877	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agggcgaccaagaggccacaGaaggccgaaaacagtgccgg	15	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:233314877G>A	uc001hvl.2	-	16	3346	c.3111C>T	c.(3109-3111)TTC>TTT	p.F1037F	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1037	Helical; (Potential).					integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				AGAGGCCACAGAAGGCCGAAA	0.512													0	0	0	0.001368	0	10	57										A	233314877	G	A	233314877	2	1	96	1	0	0	0	0	0	0	0	1	11592	933	33	1		1	PCNXL2	1	233314877	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5024823	233314877	15935744	106	28582										
IRF2BP2	359948	broad.mit.edu	37	chr1	234744657	234744657	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggtgggcagcggcgtggccGagccgttcatgagcggcacc	18	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:234744657G>A	uc001hwg.2	-	1	615	c.584C>T	c.(583-585)TCG>TTG	p.S195L	IRF2BP2_uc009xfw.2_5'Flank|IRF2BP2_uc001hwf.2_Missense_Mutation_p.S195L	NM_182972	NP_892017	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	195	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			CGGCGTGGCCGAGCCGTTCAT	0.766													0	0	0	0.001984	0	7	15										A	234744657	G	A	234744657	3	1	96	1	0	0	0	0	1	0	0	0	7830	1059	37	1	1187	1	IRF2BP2	1	234744657	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1429780	234744657	14505964	107	28583										
RYR2	6262	broad.mit.edu	37	chr1	237819236	237819236	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatgatggaaaaacagtcatCaatggattctgaagggaact	10	5	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:237819236C>T	uc001hyl.1	+	53	8201	c.8081C>T	c.(8080-8082)TCA>TTA	p.S2694L		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2694	Modulator (Potential).|Cytoplasmic (By similarity).|3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAACAGTCATCAATGGATTCT	0.413													0	0	0	0.008291	0	10	23										T	237819236	C	T	237819236	3	4	96	1	0	0	0	0	1	0	0	0	13769	838	29	1	8291	1	RYR2	1	237819236	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3074579	237819236	11431385	108	28584										
CNST	163882	broad.mit.edu	37	chr1	246811273	246811273	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcatcctatagtctccaggaGaatctgccttctgatgagag	10	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:246811273G>A	uc001ibp.2	+	9	2148	c.1770G>A	c.(1768-1770)GAG>GAA	p.E590E	CNST_uc001ibo.3_Silent_p.E590E	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	590					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GTCTCCAGGAGAATCTGCCTT	0.403													0	0	0	0.001786	0	31	85										A	246811273	G	A	246811273	2	1	96	1	0	0	0	0	0	0	0	1	3634	933	33	1		1	CNST	1	246811273	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8992037	246811273	2439348	109	28585										
SCCPDH	51097	broad.mit.edu	37	chr1	246923504	246923504	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttctcctttggctatttttCaaaacaaggcccaacacaaa	4	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:246923504C>G	uc001ibr.2	+	9	1312	c.965C>G	c.(964-966)TCA>TGA	p.S322*		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	322						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		GGCTATTTTTCAAAACAAGGC	0.299													0	0	0	0.005443	0	23	38										G	246923504	C	G	246923504	4	3	96	1	0	0	0	0	0	1	0	0	13885	838	29	1	999	1	SCCPDH	1	246923504	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	112231	246923504	2327117	110	28586										
OR6F1	343169	broad.mit.edu	37	chr1	247875277	247875277	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcatctttgatagaggtgcGgacgtgaaggaaaactgtgg	16	5	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:247875277G>A	uc001idj.1	-	1	781	c.781C>T	c.(781-783)CGC>TGC	p.R261C		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			ATAGAGGTGCGGACGTGAAGG	0.522													0	0	0	0.00245	0	15	71										A	247875277	G	A	247875277	3	1	96	1	0	0	0	0	1	0	0	0	11201	1116	39	2	149	2	OR6F1	1	247875277	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	951773	247875277	1375344	111	28587										
OR2T12	127064	broad.mit.edu	37	chr1	248458107	248458107	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacctgtgggatttgggtctCatataggtaaaaatgccagc	12	7	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr1:248458107C>T	uc010pzj.1	-	1	774	c.774G>A	c.(772-774)ATG>ATA	p.M258I		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	258	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATTTGGGTCTCATATAGGTAA	0.483													0	0	0	0.003954	0	27	126										T	248458107	C	T	248458107	3	4	96	1	0	0	0	0	1	0	0	0	11019	826	29	1	191	1	OR2T12	1	248458107	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	582830	248458107	792514	112	28588										
TMEM18	129787	broad.mit.edu	37	chr2	675513	675513	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtgttgttttactcacctaGacacagaaagtgcccgatct	8	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:675513G>T	uc002qwl.2	-	2	269	c.175C>A	c.(175-177)CTA>ATA	p.L59I	TMEM18_uc002qwk.2_RNA|uc002qwm.1_5'Flank	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	59	Helical; (Potential).				cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		TACTCACCTAGACACAGAAAG	0.483													1	0	3.86212e-05	0.008291	4.61915e-05	9	113										T	675513	G	T	675513	3	4	96	1	0	0	0	0	1	0	0	0	16095	933	33	3	263	3	TMEM18	2	675513	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		675513	242523860	113	28589										
SNTG2	54221	broad.mit.edu	37	chr2	1263181	1263181	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcgagcagaaaggacctatCacctctgtgaggtgctattt	11	9	2	2	rs145354756	by1000genomes	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:1263181C>G	uc002qwq.2	+	13	1173	c.1045C>G	c.(1045-1047)CAC>GAC	p.H349D	SNTG2_uc010ewi.2_Missense_Mutation_p.H222D	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	349	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AAGGACCTATCACCTCTGTGA	0.413													0	0	0	0.003755	0	30	64										G	1263181	C	G	1263181	3	3	96	1	0	0	0	0	1	0	0	0	14875	826	29	1	1095	1	SNTG2	2	1263181	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	587668	1263181	241936192	114	28590										
COLEC11	78989	broad.mit.edu	37	chr2	3660949	3660949	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgcccccggacggcctggaaGagtcggccccacgggagaaa	15	15	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:3660949G>C	uc002qya.2	+	3	327	c.179G>C	c.(178-180)AGA>ACA	p.R60T	COLEC11_uc002qxz.2_Missense_Mutation_p.E31Q|COLEC11_uc002qyb.2_Intron|COLEC11_uc002qyc.2_Missense_Mutation_p.R60T|COLEC11_uc010ewo.2_Intron|COLEC11_uc010ewp.2_Missense_Mutation_p.R34T|COLEC11_uc010ewq.2_Intron|COLEC11_uc010ewr.2_Missense_Mutation_p.R34T|COLEC11_uc010ews.2_Intron	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	60						collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CGGCCTGGAAGAGTCGGCCCC	0.647													0	0	0	0.000602	0	4	17										C	3660949	G	C	3660949	3	2	96	1	0	0	0	0	1	0	0	0	3711	943	33	1	185	1	COLEC11	2	3660949	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2397768	3660949	239538424	115	28591										
KLF11	8462	broad.mit.edu	37	chr2	10187909	10187909	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgccgtagtggccagagctCtgagcgggggcgcggagagg	20	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:10187909C>G	uc002raf.1	+	3	607	c.445C>G	c.(445-447)CTG>GTG	p.L149V	KLF11_uc010yjc.1_Missense_Mutation_p.L132V	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	149				VVARALS -> QWPDSD (in Ref. 3).	apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GGCCAGAGCTCTGAGCGGGGG	0.612													0	0	0	0.00278	0	23	51										G	10187909	C	G	10187909	3	3	96	1	0	0	0	0	1	0	0	0	8339	912	32	1	455	1	KLF11	2	10187909	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6526960	10187909	233011464	116	28592										
RRM2	6241	broad.mit.edu	37	chr2	10269373	10269373	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttttcaggttttcagagtaGagaacccatttgactttatg	8	7	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:10269373G>C	uc002rah.2	+	10	1221	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	344					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		TTTCAGAGTAGAGAACCCATT	0.378													0	0	0	0.004482	0	9	53										C	10269373	G	C	10269373	3	2	96	1	0	0	0	0	1	0	0	0	13682	943	33	1	1248	1	RRM2	2	10269373	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	81464	10269373	232930000	117	28593										
GREB1	9687	broad.mit.edu	37	chr2	11756766	11756766	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttttggaacaggctctacctCggagaagagaagccccatga	11	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:11756766C>G	uc002rbk.1	+	21	3632	c.3332C>G	c.(3331-3333)TCG>TGG	p.S1111W	GREB1_uc002rbp.1_Missense_Mutation_p.S109W	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1111	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GGCTCTACCTCGGAGAAGAGA	0.413													0	0	0	0.00632	0	27	168										G	11756766	C	G	11756766	3	3	96	1	0	0	0	0	1	0	0	0	6760	893	31	1	3518	1	GREB1	2	11756766	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1487393	11756766	231442607	118	28594										
MYCN	4613	broad.mit.edu	37	chr2	16082244	16082244	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctgcaagaacccagacctcGagtttgactcgctacagccc	8	15	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:16082244G>C	uc002rci.2	+	2	358	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Missense_Mutation_p.E12Q	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	20					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			CCCAGACCTCGAGTTTGACTC	0.642			A		neuroblastoma								0	0	0	0.000602	0	5	41										C	16082244	G	C	16082244	3	2	96	1	0	0	0	0	1	0	0	0	10021	1059	37	1	60	1	MYCN	2	16082244	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4325478	16082244	227117129	119	28595										
HADHA	3030	broad.mit.edu	37	chr2	26414459	26414459	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgactgcctcattcacaaatCttgtcaccaggcggaactgg	9	12	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:26414459C>G	uc002rgy.2	-	19	2169	c.2039G>C	c.(2038-2040)AGA>ACA	p.R680T	HADHA_uc010yks.1_Missense_Mutation_p.R593T	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	680					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	ATTCACAAATCTTGTCACCAG	0.542													0	0	0	0.007835	0	38	61										G	26414459	C	G	26414459	3	3	96	1	0	0	0	0	1	0	0	0	6943	913	32	1	260	1	HADHA	2	26414459	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10332215	26414459	216784914	120	28596										
HADHB	3032	broad.mit.edu	37	chr2	26501592	26501592	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaatgagaaaactgatgcttGatctcaataaggccaaatct	7	7	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:26501592G>C	uc002rgz.2	+	8	804	c.553G>C	c.(553-555)GAT>CAT	p.D185H	HADHB_uc010ykv.1_Missense_Mutation_p.D163H|HADHB_uc010ykw.1_Missense_Mutation_p.D170H|HADHB_uc002rha.2_Intron|HADHB_uc010ykx.1_Missense_Mutation_p.D111H	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	185					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTGATGCTTGATCTCAATAA	0.453													0	0	0	0.000978	0	12	81										C	26501592	G	C	26501592	3	2	96	1	0	0	0	0	1	0	0	0	6944	1290	45	1	579	1	HADHB	2	26501592	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	87133	26501592	216697781	121	28597										
PPP1CB	5500	broad.mit.edu	37	chr2	29016810	29016810	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caaattactgtggcgagtttGataatgctggtggaatgatg	13	4	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:29016810G>C	uc002rmg.2	+	8	986	c.826G>C	c.(826-828)GAT>CAT	p.D276H	PPP1CB_uc010ymj.1_Missense_Mutation_p.D248H|PPP1CB_uc010yml.1_Missense_Mutation_p.D248H|PPP1CB_uc002rmh.2_Missense_Mutation_p.D276H|SPDYA_uc002rmi.2_5'UTR	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	276					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)					TGGCGAGTTTGATAATGCTGG	0.348													0	0	0	0.00333	0	25	53										C	29016810	G	C	29016810	3	2	96	1	0	0	0	0	1	0	0	0	12350	1290	45	1	852	1	PPP1CB	2	29016810	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2515218	29016810	214182563	122	28598										
ALK	238	broad.mit.edu	37	chr2	29519819	29519819	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcaagccttcataggcggcGacatgccagaccatcctgcc	9	16	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:29519819G>A	uc002rmy.2	-	9	2659	c.1752C>T	c.(1750-1752)GTC>GTT	p.V584V		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	584	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CATAGGCGGCGACATGCCAGA	0.557			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.001368	0	12	38										A	29519819	G	A	29519819	2	1	96	1	0	0	0	0	0	0	0	1	525	1045	37	1		1	ALK	2	29519819	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	503009	29519819	213679554	123	28599										
BIRC6	57448	broad.mit.edu	37	chr2	32678919	32678919	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagctgctgagggtagtttCacatctctcactggactttt	9	10	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:32678919C>T	uc010ezu.2	+	23	4796	c.4662C>T	c.(4660-4662)TTC>TTT	p.F1554F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1554					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AGGGTAGTTTCACATCTCTCA	0.383													0	0	0	0.00361	0	70	125										T	32678919	C	T	32678919	2	4	96	1	0	0	0	0	0	0	0	1	1438	825	29	1		1	BIRC6	2	32678919	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3159100	32678919	210520454	124	28600										
EIF2AK2	5610	broad.mit.edu	37	chr2	37374019	37374019	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttttccttattaagtatctCaacagctaatttggctgcgg	7	9	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:37374019C>G	uc010ynh.1	-	4	774	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	EIF2AK2_uc010fab.1_Missense_Mutation_p.E73Q|EIF2AK2_uc010yng.1_Missense_Mutation_p.E73Q|EIF2AK2_uc010fac.2_Missense_Mutation_p.E73Q|EIF2AK2_uc010fad.2_Missense_Mutation_p.E73Q	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	73	DRBM 1.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TTAAGTATCTCAACAGCTAAT	0.343													0	0	0	0.003954	0	26	64										G	37374019	C	G	37374019	3	3	96	1	0	0	0	0	1	0	0	0	4997	835	29	1	1494	1	EIF2AK2	2	37374019	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4695100	37374019	205825354	125	28601										
SOS1	6654	broad.mit.edu	37	chr2	39249913	39249913	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcattgttacatcaagcatCctttccagtgtactccggta	7	11	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39249913C>G	uc002rrk.3	-	10	1697	c.1656G>C	c.(1654-1656)AGG>AGC	p.R552S	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.R166S|SOS1_uc002rrl.2_Missense_Mutation_p.R284S	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	552			R -> G (in NS4; increases the basal level of active RAS; prolonges RAS activation after EGF stimulation and enhances ERK activation).|R -> S (in NS4).|R -> K (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				CATCAAGCATCCTTTCCAGTG	0.403									Noonan_syndrome				0	0	0	0.008361	0	29	83										G	39249913	C	G	39249913	3	3	96	1	0	0	0	0	1	0	0	0	14936	854	30	1	2401	1	SOS1	2	39249913	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1875894	39249913	203949460	126	28602										
SOS1	6654	broad.mit.edu	37	chr2	39250197	39250197	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaagagaaatatgtgtctctCatgtttggctcctacacgtg	9	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39250197C>T	uc002rrk.3	-	10	1413	c.1372G>A	c.(1372-1374)GAG>AAG	p.E458K	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_Missense_Mutation_p.E72K|SOS1_uc002rrl.2_Missense_Mutation_p.E190K	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	458	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				ATGTGTCTCTCATGTTTGGCT	0.388									Noonan_syndrome				0	0	0	0.004878	0	37	75										T	39250197	C	T	39250197	3	4	96	1	0	0	0	0	1	0	0	0	14936	835	29	1	2685	1	SOS1	2	39250197	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	284	39250197	203949176	127	28603										
MAP4K3	8491	broad.mit.edu	37	chr2	39477777	39477777	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcagtaactgttttcatgAcccgccaggatgtacaaatt	7	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39477777A>G	uc002rro.2	-	34	2758	c.2667T>C	c.(2665-2667)GGT>GGC	p.G889G	MAP4K3_uc002rrp.2_Silent_p.G868G|MAP4K3_uc010yns.1_Silent_p.G442G	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	889					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TGTTTTCATGACCCGCCAGGA	0.378													0	0	0	0.00308	0	7	35										G	39477777	A	G	39477777	2	3	96	1	0	0	0	0	0	0	0	1	9261	262	10	5		5	MAP4K3	2	39477777	Silent	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	227580	39477777	203721596	128	28604										
MAP4K3	8491	broad.mit.edu	37	chr2	39505625	39505625	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcaccaaatatcaagtactGatctgaaataaaagtaattc	6	7	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:39505625G>A	uc002rro.2	-	24	1808	c.1717C>T	c.(1717-1719)CAG>TAG	p.Q573*	MAP4K3_uc002rrp.2_Nonsense_Mutation_p.Q552*|MAP4K3_uc010yns.1_Nonsense_Mutation_p.Q126*	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	573	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				ATCAAGTACTGATCTGAAATA	0.254													0	0	0	0.001984	0	6	37										A	39505625	G	A	39505625	4	1	96	1	0	0	0	0	0	1	0	0	9261	1299	45	1	1011	1	MAP4K3	2	39505625	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	27848	39505625	203693748	129	28605										
PLEKHH2	130271	broad.mit.edu	37	chr2	43937240	43937240	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagctcccaaaaacttgctCatcttccagtgataatggga	8	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:43937240C>T	uc010yny.1	+	12	2161	c.2078C>T	c.(2077-2079)TCA>TTA	p.S693L	PLEKHH2_uc002rte.3_Missense_Mutation_p.S693L|PLEKHH2_uc002rtf.3_Missense_Mutation_p.S692L	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	693	Poly-Ser.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAAACTTGCTCATCTTCCAGT	0.398													0	0	0	0.008291	0	11	100										T	43937240	C	T	43937240	3	4	96	1	0	0	0	0	1	0	0	0	12077	838	29	1	2120	1	PLEKHH2	2	43937240	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4431615	43937240	199262133	130	28606										
PLEKHH2	130271	broad.mit.edu	37	chr2	43992600	43992600	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttacataaacaacttccatCagcaaaaggcagcatttcac	5	11	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:43992600C>T	uc010yny.1	+	30	4428	c.4345C>T	c.(4345-4347)CAG>TAG	p.Q1449*		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1449	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CAACTTCCATCAGCAAAAGGC	0.468													0	0	0	0.001786	0	27	53										T	43992600	C	T	43992600	4	4	96	1	0	0	0	0	0	1	0	0	12077	827	29	1	4459	1	PLEKHH2	2	43992600	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	55360	43992600	199206773	131	28607										
SIX3	6496	broad.mit.edu	37	chr2	45169727	45169727	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaagttcaccaaggagtctCacggcaagctgcaggccatg	11	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:45169727C>T	uc002run.1	+	1	691	c.484C>T	c.(484-486)CAC>TAC	p.H162Y		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	162					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAAGGAGTCTCACGGCAAGCT	0.662													0	0	0	0.001984	0	6	21										T	45169727	C	T	45169727	3	4	96	1	0	0	0	0	1	0	0	0	14348	826	29	1	486	1	SIX3	2	45169727	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1177127	45169727	198029646	132	28608										
GPR75	10936	broad.mit.edu	37	chr2	54080974	54080974	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtggagaggttgatggctGatacgagctggagtcggctt	17	6	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:54080974G>A	uc002rxo.3	-	2	1191	c.920C>T	c.(919-921)TCA>TTA	p.S307L	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	307	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTTGATGGCTGATACGAGCTG	0.532													0	0	0	0.008291	0	11	41										A	54080974	G	A	54080974	3	1	96	1	0	0	0	0	1	0	0	0	6708	1294	45	1	706	1	GPR75	2	54080974	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8911247	54080974	189118399	133	28609										
RAB11FIP5	26056	broad.mit.edu	37	chr2	73339501	73339501	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgctgggcgcggcctgcgccGaagacctcgtccagcgccac	14	17	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:73339501G>A	uc002siu.3	-	1	646	c.405C>T	c.(403-405)TTC>TTT	p.F135F		NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	135					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GGCCTGCGCCGAAGACCTCGT	0.711													0	0	0	0.008871	0	17	22										A	73339501	G	A	73339501	2	1	96	1	0	0	0	0	0	0	0	1	12897	1049	37	1		1	RAB11FIP5	2	73339501	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	19258527	73339501	169859872	134	28610										
RAB11FIP5	26056	broad.mit.edu	37	chr2	73339600	73339600	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accagctcgcaggcggcggcGgagctcgcggcccagggcgc	18	16	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:73339600G>A	uc002siu.3	-	1	547	c.306C>T	c.(304-306)TCC>TCT	p.S102S		NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	102	C2.				protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						AGGCGGCGGCGGAGCTCGCGG	0.751													0	0	0	0.001984	0	6	14										A	73339600	G	A	73339600	2	1	96	1	0	0	0	0	0	0	0	1	12897	1103	39	2		2	RAB11FIP5	2	73339600	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	99	73339600	169859773	135	28611										
NAT8B	51471	broad.mit.edu	37	chr2	73928087	73928087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tactgtgcccaccaccttctCttcagattcacccacccaga	4	18	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:73928087C>G	uc002sjk.1	-	2	381	c.346G>C	c.(346-348)GAG>CAG	p.E116Q		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	116	N-acetyltransferase.				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						ACCACCTTCTCTTCAGATTCA	0.537													0	0	0	0.003163	0	14	68										G	73928087	C	G	73928087	3	3	96	1	0	0	0	0	1	0	0	0	10180	922	32	1	341	1	NAT8B	2	73928087	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	588487	73928087	169271286	136	28612										
BOLA3	388962	broad.mit.edu	37	chr2	74372361	74372361	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtagctcgtggaaacttttCtttgagaatttgggtcactc	10	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:74372361C>G	uc002skc.1	-	2	162	c.124G>C	c.(124-126)GAA>CAA	p.E42Q	BOLA3_uc002skd.1_Missense_Mutation_p.E42Q|uc002ske.2_5'Flank|uc002skf.2_5'Flank|uc002skg.2_5'Flank	NM_212552	NP_997717	Q53S33	BOLA3_HUMAN	bolA-like 3 isoform 1	42						extracellular region					0						GGAAACTTTTCTTTGAGAATT	0.478													0	0	0	0.006214	0	10	74										G	74372361	C	G	74372361	3	3	96	1	0	0	0	0	1	0	0	0	1486	922	32	1	282	1	BOLA3	2	74372361	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	444274	74372361	168827012	137	28613										
DCTN1	1639	broad.mit.edu	37	chr2	74598163	74598163	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgctgctcctgcattttgctCttccattcctgcacctgctc	6	16	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:74598163C>G	uc002skx.2	-	9	1097	c.786G>C	c.(784-786)AAG>AAC	p.K262N	DCTN1_uc002skv.2_Missense_Mutation_p.K128N|DCTN1_uc002sku.2_Missense_Mutation_p.K128N|DCTN1_uc002skw.1_Missense_Mutation_p.K238N|DCTN1_uc010ffd.2_Missense_Mutation_p.K242N|DCTN1_uc002sky.2_Missense_Mutation_p.K225N	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	262	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GCATTTTGCTCTTCCATTCCT	0.552													0	0	0	0.00361	0	59	373										G	74598163	C	G	74598163	3	3	96	1	0	0	0	0	1	0	0	0	4306	912	32	1	3146	1	DCTN1	2	74598163	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	225802	74598163	168601210	138	28614										
LOXL3	84695	broad.mit.edu	37	chr2	74762786	74762786	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcctccagggtcccccagtCatccccacagatgaggcccc	10	19	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:74762786C>T	uc002smp.1	-	8	1417	c.1345G>A	c.(1345-1347)GAC>AAC	p.D449N	LOXL3_uc002smo.1_Missense_Mutation_p.D88N|LOXL3_uc010ffm.1_Intron|LOXL3_uc002smq.1_Missense_Mutation_p.D304N|LOXL3_uc010ffn.1_Missense_Mutation_p.D304N	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	449	SRCR 4.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						GTCCCCCAGTCATCCCCACAG	0.662													0	0	0	0.00333	0	23	114										T	74762786	C	T	74762786	3	4	96	1	0	0	0	0	1	0	0	0	8901	826	29	1	944	1	LOXL3	2	74762786	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	164623	74762786	168436587	139	28615										
C2orf3	6936	broad.mit.edu	37	chr2	75915007	75915007	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcagacaagacttttttatCtgaactactttccttctttg	5	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:75915007C>G	uc002sno.2	-	11	1766	c.1636G>C	c.(1636-1638)GAT>CAT	p.D546H	C2orf3_uc010ffs.2_Missense_Mutation_p.D108H|C2orf3_uc002snn.2_Missense_Mutation_p.D377H|C2orf3_uc010fft.2_Missense_Mutation_p.D221H	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	546					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						ACTTTTTTATCTGAACTACTT	0.348													0	0	0	0.004482	0	8	55										G	75915007	C	G	75915007	3	3	96	1	0	0	0	0	1	0	0	0	2162	913	32	1	737	1	C2orf3	2	75915007	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1152221	75915007	167284366	140	28616										
KCMF1	56888	broad.mit.edu	37	chr2	85262250	85262250	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttcaagaacatgttacttCtgaacatgcagaaacatcaa	5	9	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:85262250C>G	uc002sox.3	+	3	640	c.296C>G	c.(295-297)TCT>TGT	p.S99C		NM_020122	NP_064507	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1	99	C2H2-type.					intracellular	ligase activity|zinc ion binding			ovary(2)	2						CATGTTACTTCTGAACATGCA	0.378													0	0	0	0.00499	0	16	24										G	85262250	C	G	85262250	3	3	96	1	0	0	0	0	1	0	0	0	8000	913	32	1	306	1	KCMF1	2	85262250	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9347243	85262250	157937123	141	28617										
VAMP5	10791	broad.mit.edu	37	chr2	85820206	85820206	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgtgctgctggtcgtctttCtccctcagagcagtgacagc	11	12	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:85820206C>T	uc002spu.1	+	3	360	c.277C>T	c.(277-279)CTC>TTC	p.L93F	RNF181_uc002spv.1_5'Flank	NM_006634	NP_006625	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	93	Helical; Anchor for type IV membrane protein; (Potential).				cell differentiation|vesicle-mediated transport	endomembrane system					0						GGTCGTCTTTCTCCCTCAGAG	0.592													0	0	0	0.003163	0	15	65										T	85820206	C	T	85820206	3	4	96	1	0	0	0	0	1	0	0	0	17113	913	32	1	287	1	VAMP5	2	85820206	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	557956	85820206	157379167	142	28618										
SEMA4C	54910	broad.mit.edu	37	chr2	97529515	97529515	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggccccaggctcacagccttGagcagccagccgtctcctgg	12	17	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:97529515G>C	uc002sxh.3	-	12	1507	c.1347C>G	c.(1345-1347)CTC>CTG	p.L449L	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Silent_p.L502L	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	449	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						TCACAGCCTTGAGCAGCCAGC	0.617													0	0	0	0.000602	0	4	49										C	97529515	G	C	97529515	2	2	96	1	0	0	0	0	0	0	0	1	14033	1277	45	1		1	SEMA4C	2	97529515	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	11709309	97529515	145669858	143	28619										
TMEM131	23505	broad.mit.edu	37	chr2	98377308	98377308	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaaaagtggggttgccgttCttgcccgggagcgaggctgc	17	10	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:98377308C>G	uc002syh.3	-	37	5188	c.4959G>C	c.(4957-4959)AAG>AAC	p.K1653N	TMEM131_uc002syg.2_Missense_Mutation_p.K33N	NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1653						integral to membrane				ovary(4)|central_nervous_system(2)	6						GGTTGCCGTTCTTGCCCGGGA	0.537													0	0	0	0.003163	0	15	69										G	98377308	C	G	98377308	3	3	96	1	0	0	0	0	1	0	0	0	16041	912	32	1	712	1	TMEM131	2	98377308	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	847793	98377308	144822065	144	28620										
GPR45	11250	broad.mit.edu	37	chr2	105859262	105859262	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctgtggctcagttacctcaAgtccgtcttcaaccccatcg	7	16	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:105859262A>C	uc002tco.1	+	1	1063	c.947A>C	c.(946-948)AAG>ACG	p.K316T		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	316	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AGTTACCTCAAGTCCGTCTTC	0.547													0	0	0	0.007413	0	19	127										C	105859262	A	C	105859262	3	2	96	1	0	0	0	0	1	0	0	0	6696	72	3	5	949	5	GPR45	2	105859262	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	7481954	105859262	137340111	145	28621										
CBWD2	150472	broad.mit.edu	37	chr2	114220043	114220043	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagacttggttccagaagaaGatgtaaagaaattaagagcg	11	5	0	6			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:114220043G>A	uc002tju.2	+	8	812	c.634G>A	c.(634-636)GAT>AAT	p.D212N	CBWD2_uc010yxw.1_Missense_Mutation_p.D176N|CBWD2_uc002tjv.2_Missense_Mutation_p.D176N|CBWD2_uc010fkv.2_RNA	NM_172003	NP_742000	Q8IUF1	CBWD2_HUMAN	COBW domain-containing protein 2	212							ATP binding|protein binding				0						TCCAGAAGAAGATGTAAAGAA	0.323													0	0	0	0.002852	0	40	95										A	114220043	G	A	114220043	3	1	96	1	0	0	0	0	1	0	0	0	2713	942	33	1	664	1	CBWD2	2	114220043	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8360781	114220043	128979330	146	28622										
STEAP3	55240	broad.mit.edu	37	chr2	120003084	120003084	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccaccaaaatgccagaagaGatggacaagccactgatcag	10	11	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:120003084G>C	uc002tlp.2	+	3	169	c.12G>C	c.(10-12)GAG>GAC	p.E4D	STEAP3_uc002tlq.2_Missense_Mutation_p.E14D|STEAP3_uc002tlr.2_Missense_Mutation_p.E4D|STEAP3_uc010fle.2_Missense_Mutation_p.E4D	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	4	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						TGCCAGAAGAGATGGACAAGC	0.587													0	0	0	0.001168	0	5	55										C	120003084	G	C	120003084	3	2	96	1	0	0	0	0	1	0	0	0	15278	933	33	1	48	1	STEAP3	2	120003084	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5783041	120003084	123196289	147	28623										
MYO7B	4648	broad.mit.edu	37	chr2	128388376	128388376	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgcttgccatgtcaccagaGaagaggaagctggcggctca	13	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:128388376G>C	uc002top.2	+	35	4805	c.4752G>C	c.(4750-4752)GAG>GAC	p.E1584D	MYO7B_uc002tor.1_Missense_Mutation_p.E437D	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1584						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGTCACCAGAGAAGAGGAAGC	0.637													0	0	0	0.000602	0	5	45										C	128388376	G	C	128388376	3	2	96	1	0	0	0	0	1	0	0	0	10083	933	33	1	4886	1	MYO7B	2	128388376	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8385292	128388376	114810997	148	28624										
MCM6	4175	broad.mit.edu	37	chr2	136626327	136626327	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtctgacagtccaagcacaGaaaagttccgctcacaagct	8	12	2	2	rs34276971		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:136626327G>A	uc002tuw.2	-	4	545	c.469C>T	c.(469-471)CTG>TTG	p.L157L		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	157					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCCAAGCACAGAAAAGTTCCG	0.517													0	0	0	0.00623	0	41	99										A	136626327	G	A	136626327	2	1	96	1	0	0	0	0	0	0	0	1	9391	933	33	1		1	MCM6	2	136626327	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8237951	136626327	106573046	149	28625										
CXCR4	7852	broad.mit.edu	37	chr2	136872950	136872950	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaagcggtcacagatatatCtgtcatctgcctcactgacg	9	11	5	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:136872950C>T	uc002tuz.2	-	2	643	c.548G>A	c.(547-549)AGA>AAA	p.R183K	CXCR4_uc002tuy.2_Missense_Mutation_p.R187K|CXCR4_uc010fnk.2_Missense_Mutation_p.R168K	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	183	Extracellular.			R->A: Reduced coreceptor activity for several HIV-1 isolates.	activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	ACAGATATATCTGTCATCTGC	0.507													0	0	0	0.001368	0	13	84										T	136872950	C	T	136872950	3	4	96	1	0	0	0	0	1	0	0	0	4093	913	32	1	514	1	CXCR4	2	136872950	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	246623	136872950	106326423	150	28626										
THSD7B	80731	broad.mit.edu	37	chr2	137852590	137852590	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggatttaggagcaggagccgGaacgtgaagcacatggctat	15	7	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:137852590G>A	uc002tva.1	+	3	1005	c.1005G>A	c.(1003-1005)CGG>CGA	p.R335R	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Silent_p.R225R	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCAGGAGCCGGAACGTGAAGC	0.537													0	0	0	0.00308	0	7	47										A	137852590	G	A	137852590	2	1	96	1	0	0	0	0	0	0	0	1	15877	1161	41	1		1	THSD7B	2	137852590	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	979640	137852590	105346783	151	28627										
LRP1B	53353	broad.mit.edu	37	chr2	141762977	141762977	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acccggcctcctgggatagcCaagcaaagtgtactacagcc	10	14	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:141762977C>G	uc002tvj.1	-	15	3402	c.2430G>C	c.(2428-2430)TTG>TTC	p.L810F	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	810	Extracellular (Potential).|EGF-like 3.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGGATAGCCAAGCAAAGTG	0.433										TSP Lung(27;0.18)			0	0	0	0.006214	0	9	72										G	141762977	C	G	141762977	3	3	96	1	0	0	0	0	1	0	0	0	8955	593	21	4	11677	4	LRP1B	2	141762977	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3910387	141762977	101436396	152	28628										
ARHGAP15	55843	broad.mit.edu	37	chr2	144194515	144194515	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttgtccatcaagaaacctgGaattattcaaaatccaaaga	6	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:144194515G>C	uc002tvm.3	+	8	758	c.607G>C	c.(607-609)GAA>CAA	p.E203Q	ARHGAP15_uc010zbl.1_Missense_Mutation_p.E203Q|ARHGAP15_uc002tvn.2_5'UTR	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	203					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		AAGAAACCTGGAATTATTCAA	0.338													0	0	0	0.001368	0	11	38										C	144194515	G	C	144194515	3	2	96	1	0	0	0	0	1	0	0	0	866	1175	41	1	633	1	ARHGAP15	2	144194515	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2431538	144194515	99004858	153	28629										
ARHGAP15	55843	broad.mit.edu	37	chr2	144194548	144194548	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccaaagatcctctagcactGaattgctaagtcactacgac	6	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:144194548G>A	uc002tvm.3	+	8	791	c.640G>A	c.(640-642)GAA>AAA	p.E214K	ARHGAP15_uc010zbl.1_Missense_Mutation_p.E214K|ARHGAP15_uc002tvn.2_5'UTR	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	214					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		CTCTAGCACTGAATTGCTAAG	0.333													0	0	0	0.001984	0	6	39										A	144194548	G	A	144194548	3	1	96	1	0	0	0	0	1	0	0	0	866	1291	45	1	666	1	ARHGAP15	2	144194548	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	33	144194548	99004825	154	28630										
STAM2	10254	broad.mit.edu	37	chr2	153006744	153006744	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtactcattcgtggctttttCtataaaatatattggcatac	6	7	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:153006744C>T	uc002tyc.3	-	2	391	c.41_splice	c.e2-1	p.E14_splice	STAM2_uc010foa.1_Splice_Site_p.E14_splice|STAM2_uc002tyd.2_Splice_Site_p.E14_splice	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		GTGGCTTTTTCTATAAAATAT	0.353													0	0	0	0.000602	0	4	29										T	153006744	C	T	153006744	5	4	96	1	0	0	0	0	0	0	1	0	15248	927	32	1	1589	1	STAM2	2	153006744	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	8812196	153006744	90192629	155	28631										
BAZ2B	29994	broad.mit.edu	37	chr2	160182266	160182266	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagtgttttcctccatttttCttttcttgaggtctttgttt	6	7	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:160182266C>A	uc002uao.2	-	35	6459	c.6107G>T	c.(6106-6108)AGA>ATA	p.R2036I	BAZ2B_uc002uap.2_Missense_Mutation_p.R2000I	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	2036					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTCCATTTTTCTTTTCTTGAG	0.353													1	0	2.40579e-17	0.00623	3.03889e-17	39	84										A	160182266	C	A	160182266	3	1	96	1	0	0	0	0	1	0	0	0	1332	913	32	3	411	3	BAZ2B	2	160182266	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7175522	160182266	83017107	156	28632										
GRB14	2888	broad.mit.edu	37	chr2	165349549	165349549	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtcacttctggcttgtctaGagagcaatcctagcacaata	8	10	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:165349549G>C	uc002ucl.2	-	14	2161	c.1620C>G	c.(1618-1620)CTC>CTG	p.L540L	GRB14_uc010zcv.1_Silent_p.L453L|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	540					blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GGCTTGTCTAGAGAGCAATCC	0.353													0	0	0	0.006122	0	18	47										C	165349549	G	C	165349549	2	2	96	1	0	0	0	0	0	0	0	1	6757	929	33	1		1	GRB14	2	165349549	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5167283	165349549	77849824	157	28633										
SCN2A	6326	broad.mit.edu	37	chr2	166198839	166198839	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttcacagcagaaatgtttCtcaagataattgccatggat	7	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:166198839C>T	uc002udc.2	+	15	2712	c.2422C>T	c.(2422-2424)CTC>TTC	p.L808F	SCN2A_uc002udd.2_Missense_Mutation_p.L808F|SCN2A_uc002ude.2_Missense_Mutation_p.L808F	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	808	II.|Helical; Name=S2 of repeat II; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGAAATGTTTCTCAAGATAAT	0.343													0	0	0	0.004656	0	24	51										T	166198839	C	T	166198839	3	4	96	1	0	0	0	0	1	0	0	0	13916	913	32	1	2572	1	SCN2A	2	166198839	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	849290	166198839	77000534	158	28634										
SCN2A	6326	broad.mit.edu	37	chr2	166231393	166231393	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgagtgcaaagctctcattGagagcaatcaaactgccagg	11	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:166231393G>C	uc002udc.2	+	22	4461	c.4171G>C	c.(4171-4173)GAG>CAG	p.E1391Q	SCN2A_uc002udd.2_Missense_Mutation_p.E1391Q|SCN2A_uc002ude.2_Missense_Mutation_p.E1391Q	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1391	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AGCTCTCATTGAGAGCAATCA	0.378													0	0	0	0.002299	0	22	35										C	166231393	G	C	166231393	3	2	96	1	0	0	0	0	1	0	0	0	13916	1291	45	1	4349	1	SCN2A	2	166231393	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	32554	166231393	76967980	159	28635										
SCN1A	6323	broad.mit.edu	37	chr2	166898905	166898905	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggaaagaacttgaccttctCtttctcatttcagtttcagt	6	9	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:166898905C>G	uc010zcz.1	-	12	2058	c.2040G>C	c.(2038-2040)AAG>AAC	p.K680N	SCN1A_uc002udo.3_Missense_Mutation_p.K560N|SCN1A_uc010fpk.2_Missense_Mutation_p.K532N	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	691						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTGACCTTCTCTTTCTCATTT	0.368													0	0	0	0.00632	0	29	45										G	166898905	C	G	166898905	3	3	96	1	0	0	0	0	1	0	0	0	13914	912	32	1	4016	1	SCN1A	2	166898905	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	667512	166898905	76300468	160	28636										
ITGA6	3655	broad.mit.edu	37	chr2	173355768	173355768	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcaggagtctcacaactcaaGaaagaaacgggaaattactg	9	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:173355768G>A	uc002uhp.1	+	21	2899	c.2696G>A	c.(2695-2697)AGA>AAA	p.R899K	ITGA6_uc010zdy.1_Missense_Mutation_p.R780K|ITGA6_uc002uho.1_Missense_Mutation_p.R899K|ITGA6_uc010fqm.1_Missense_Mutation_p.R530K	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	integrin alpha chain, alpha 6 isoform a	938	Extracellular (Potential).				blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CACAACTCAAGAAAGAAACGG	0.308													0	0	0	0.003755	0	35	191										A	173355768	G	A	173355768	3	1	96	1	0	0	0	0	1	0	0	0	7880	942	33	1	2778	1	ITGA6	2	173355768	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6456863	173355768	69843605	161	28637										
CIR1	9541	broad.mit.edu	37	chr2	175213338	175213338	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcatttcttctgctttgctCttcaccaggatttcgctgtg	8	11	5	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:175213338C>T	uc002uim.2	-	10	1333	c.1240G>A	c.(1240-1242)GAG>AAG	p.E414K	CIR1_uc002uin.2_Missense_Mutation_p.E288K|CIR1_uc002uio.2_Missense_Mutation_p.E241K|CIR1_uc002uip.2_Missense_Mutation_p.E303K	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	414	Arg/Ser-rich (RS domain).				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						CTGCTTTGCTCTTCACCAGGA	0.507													0	0	0	0.007835	0	43	251										T	175213338	C	T	175213338	3	4	96	1	0	0	0	0	1	0	0	0	3432	922	32	1	116	1	CIR1	2	175213338	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1857570	175213338	67986035	162	28638										
WIPF1	7456	broad.mit.edu	37	chr2	175436406	175436406	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctccacgtcttgtcatacctGatcggcctggcgggtccctc	10	16	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:175436406G>C	uc002uiy.2	-	6	1459	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Nonsense_Mutation_p.S376*|WIPF1_uc010fqt.1_Nonsense_Mutation_p.S376*|WIPF1_uc002ujc.1_Nonsense_Mutation_p.S376*|WIPF1_uc002uiz.2_Nonsense_Mutation_p.S376*|WIPF1_uc002ujb.1_Nonsense_Mutation_p.S376*|WIPF1_uc010zep.1_Nonsense_Mutation_p.S376*	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	376	XRSGPXPPXP motif 2.|Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						TGTCATACCTGATCGGCCTGG	0.562													0	0	0	0.003954	0	22	135										C	175436406	G	C	175436406	4	2	96	1	0	0	0	0	0	1	0	0	17364	1294	45	1	400	1	WIPF1	2	175436406	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	223068	175436406	67762967	163	28639										
TTC30B	150737	broad.mit.edu	37	chr2	178417039	178417039	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atctggccatcggtctcattCtcgcccccactttcctctcc	5	19	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:178417039C>G	uc002uln.2	-	1	486	c.453G>C	c.(451-453)GAG>GAC	p.E151D	TTC30B_uc010zfc.1_5'UTR	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	151					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			CGGTCTCATTCTCGCCCCCAC	0.582													0	0	0	0.00361	0	51	327										G	178417039	C	G	178417039	3	3	96	1	0	0	0	0	1	0	0	0	16696	912	32	1	1548	1	TTC30B	2	178417039	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2980633	178417039	64782334	164	28640										
TTN	7273	broad.mit.edu	37	chr2	179455083	179455083	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttctgctagttctcttggctCaccctctcctacaatattag	5	13	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:179455083C>T	uc010zfg.1	-	253	53889	c.53665G>A	c.(53665-53667)GAG>AAG	p.E17889K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E11584K|TTN_uc010zfi.1_Missense_Mutation_p.E11517K|TTN_uc010zfj.1_Missense_Mutation_p.E11392K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18816							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCTTGGCTCACCCTCTCCT	0.408													0	0	0	0.001855	0	14	103										T	179455083	C	T	179455083	3	4	96	1	0	0	0	0	1	0	0	0	16732	835	29	1	46846	1	TTN	2	179455083	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1038044	179455083	63744290	165	28641										
TTN	7273	broad.mit.edu	37	chr2	179611886	179611886	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggtgtggaatatctctctaGagtctctcctgggggtgtgg	16	7	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:179611886G>C	uc002unb.2	-	46	15465	c.15241C>G	c.(15241-15243)CTA>GTA	p.L5081V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	1188							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTCTCTAGAGTCTCTCCT	0.552													0	0	0	0.008361	0	30	69										C	179611886	G	C	179611886	3	2	96	1	0	0	0	0	1	0	0	0	16732	933	33	1	95056	1	TTN	2	179611886	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	156803	179611886	63587487	166	28642										
DNAH7	56171	broad.mit.edu	37	chr2	196718190	196718190	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgtggctccatcgagttttCtcacctccaaggcctccaat	8	14	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:196718190C>T	uc002utj.3	-	46	8759	c.8658G>A	c.(8656-8658)GAG>GAA	p.E2886E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2886					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATCGAGTTTTCTCACCTCCAA	0.463													0	0	0	0.004482	0	9	54										T	196718190	C	T	196718190	2	4	96	1	0	0	0	0	0	0	0	1	4606	912	32	1		1	DNAH7	2	196718190	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	17106304	196718190	46481183	167	28643										
STK17B	9262	broad.mit.edu	37	chr2	197010766	197010766	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taaacacaggctgaaaatttCtccacctgcagcactaaaat	5	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:197010766C>T	uc002utk.2	-	4	673	c.349G>A	c.(349-351)GAA>AAA	p.E117K	STK17B_uc010fsh.2_Missense_Mutation_p.E117K	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	117	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)			CTGAAAATTTCTCCACCTGCA	0.313													0	0	0	0.001168	0	6	9										T	197010766	C	T	197010766	3	4	96	1	0	0	0	0	1	0	0	0	15290	922	32	1	789	1	STK17B	2	197010766	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	292576	197010766	46188607	168	28644										
SATB2	23314	broad.mit.edu	37	chr2	200213701	200213701	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttgtggactaagctggggaGaaagaagaccagggctcatg	16	6	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:200213701G>C	uc002uuy.1	-	7	1713	c.896C>G	c.(895-897)TCT>TGT	p.S299C	SATB2_uc010fsq.1_Missense_Mutation_p.S181C|SATB2_uc002uuz.1_Missense_Mutation_p.S299C|SATB2_uc002uva.1_Missense_Mutation_p.S299C|SATB2_uc002uvb.1_Missense_Mutation_p.S42C	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	299						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAGCTGGGGAGAAAGAAGACC	0.507													0	0	0	0.00333	0	23	124										C	200213701	G	C	200213701	3	2	96	1	0	0	0	0	1	0	0	0	13854	942	33	1	1325	1	SATB2	2	200213701	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3202935	200213701	42985672	169	28645										
C2orf60	129450	broad.mit.edu	37	chr2	200803731	200803731	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagaactgttcctctttgaaGaattctggaaacttaatatc	6	7	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:200803731G>C	uc002uvi.3	-	5	677	c.411C>G	c.(409-411)TTC>TTG	p.F137L	C2orf60_uc002uvj.3_5'UTR|C2orf60_uc002uvk.3_RNA|C2orf60_uc010fss.2_5'UTR	NM_001039693	NP_001034782	A2RUC4	TYW5_HUMAN	hypothetical protein LOC129450	137	JmjC.				wybutosine biosynthetic process		iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein homodimerization activity|tRNA binding				0						CCTCTTTGAAGAATTCTGGAA	0.308													0	0	0	0.000602	0	5	36										C	200803731	G	C	200803731	3	2	96	1	0	0	0	0	1	0	0	0	2179	933	33	1	552	1	C2orf60	2	200803731	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	590030	200803731	42395642	170	28646										
ALS2CR8	79800	broad.mit.edu	37	chr2	203839184	203839184	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaaatccttgagaaatggaGatacggtatataactcagag	10	5	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:203839184G>A	uc002uzo.2	+	12	1739	c.1459G>A	c.(1459-1461)GAT>AAT	p.D487N	ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.D411N|ALS2CR8_uc010zib.1_Missense_Mutation_p.D411N|ALS2CR8_uc010zic.1_Missense_Mutation_p.D399N|ALS2CR8_uc002uzp.2_Missense_Mutation_p.D487N	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	487										large_intestine(1)|ovary(1)	2						GAGAAATGGAGATACGGTATA	0.323													0	0	0	0.004007	0	15	37										A	203839184	G	A	203839184	3	1	96	1	0	0	0	0	1	0	0	0	555	942	33	1	1497	1	ALS2CR8	2	203839184	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3035453	203839184	39360189	171	28647										
ALS2CR8	79800	broad.mit.edu	37	chr2	203842024	203842024	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagacagtgggaatattctCaaagagaccatgacagttac	9	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:203842024C>G	uc002uzo.2	+	13	1807	c.1527C>G	c.(1525-1527)CTC>CTG	p.L509L	ALS2CR8_uc010zia.1_Silent_p.L433L|ALS2CR8_uc010zib.1_Silent_p.L433L|ALS2CR8_uc010zic.1_Silent_p.L421L|ALS2CR8_uc002uzp.2_Silent_p.L509L	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	509										large_intestine(1)|ovary(1)	2						GGAATATTCTCAAAGAGACCA	0.269													0	0	0	0.005443	0	26	118										G	203842024	C	G	203842024	2	3	96	1	0	0	0	0	0	0	0	1	555	813	29	1		1	ALS2CR8	2	203842024	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2840	203842024	39357349	172	28648										
DYTN	391475	broad.mit.edu	37	chr2	207530676	207530676	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtgaatccttgtttcaaatCgacaaattctttcttcctgg	6	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:207530676C>A	uc002vbr.1	-	10	1175	c.1058G>T	c.(1057-1059)CGA>CTA	p.R353L		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	353						plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TGTTTCAAATCGACAAATTCT	0.393													1	0	3.32936e-07	0.006122	4.03219e-07	17	80										A	207530676	C	A	207530676	3	1	96	1	0	0	0	0	1	0	0	0	4861	884	31	3	690	3	DYTN	2	207530676	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3688652	207530676	35668697	173	28649										
MDH1B	130752	broad.mit.edu	37	chr2	207615685	207615685	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaatcaagtttaaaacagggCgtgaataatgaagaggtccc	10	6	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:207615685C>T	uc002vbs.2	-	6	1080	c.1025G>A	c.(1024-1026)CGC>CAC	p.R342H	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Missense_Mutation_p.R342H|MDH1B_uc010fuj.2_Missense_Mutation_p.R244H|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	342					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TAAAACAGGGCGTGAATAATG	0.328													0	0	0	0.000978	0	12	46										T	207615685	C	T	207615685	3	4	96	1	0	0	0	0	1	0	0	0	9409	768	27	2	559	2	MDH1B	2	207615685	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	85009	207615685	35583688	174	28650										
C2orf67	151050	broad.mit.edu	37	chr2	210993855	210993855	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagtccatcggctgccaactCgtgctctgtctacaagccac	8	15	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:210993855C>G	uc002vds.2	-	3	1338	c.1130G>C	c.(1129-1131)CGA>CCA	p.R377P	C2orf67_uc002vdt.2_Missense_Mutation_p.R377P|C2orf67_uc002vdw.2_Missense_Mutation_p.R377P|C2orf67_uc002vdv.2_Missense_Mutation_p.R377P|C2orf67_uc002vdx.1_Missense_Mutation_p.R377P	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	377										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		GCTGCCAACTCGTGCTCTGTC	0.433													0	0	0	0.001855	0	14	114										G	210993855	C	G	210993855	3	3	96	1	0	0	0	0	1	0	0	0	2186	884	31	1	1885	1	C2orf67	2	210993855	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3378170	210993855	32205518	175	28651										
IKZF2	22807	broad.mit.edu	37	chr2	213872434	213872434	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggtcatcatggctgctttCtgagtcagtggaatccaggc	13	9	4	1	rs76325907		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:213872434C>G	uc002vem.2	-	8	1400	c.1231G>C	c.(1231-1233)GAA>CAA	p.E411Q	IKZF2_uc010fuu.2_Missense_Mutation_p.E266Q|IKZF2_uc002vej.2_Missense_Mutation_p.E358Q|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.E337Q|IKZF2_uc002vel.2_Missense_Mutation_p.E332Q|IKZF2_uc010fuw.2_Missense_Mutation_p.E185Q|IKZF2_uc010fux.2_Missense_Mutation_p.E185Q|IKZF2_uc010fuy.2_Missense_Mutation_p.E339Q|IKZF2_uc002ven.2_Missense_Mutation_p.E385Q|IKZF2_uc002vei.2_Missense_Mutation_p.E189Q	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TGGCTGCTTTCTGAGTCAGTG	0.507													0	0	0	0.00361	0	86	171										G	213872434	C	G	213872434	3	3	96	1	0	0	0	0	1	0	0	0	7615	922	32	1	353	1	IKZF2	2	213872434	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2878579	213872434	29326939	176	28652										
ATIC	471	broad.mit.edu	37	chr2	216213870	216213870	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaggaagtccctgagttactCactgaggcagagaagaagga	14	7	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:216213870C>T	uc002vex.3	+	15	1731	c.1557C>T	c.(1555-1557)CTC>CTT	p.L519L	ATIC_uc010zjo.1_Silent_p.L460L|ATIC_uc002vey.3_Silent_p.L518L	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	519					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CTGAGTTACTCACTGAGGCAG	0.448			T	ALK	ALCL								0	0	0	0.003755	0	34	87										T	216213870	C	T	216213870	2	4	96	1	0	0	0	0	0	0	0	1	1105	813	29	1		1	ATIC	2	216213870	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2341436	216213870	26985503	177	28653										
FN1	2335	broad.mit.edu	37	chr2	216273063	216273063	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatcaaactctgctccccatCctcagatatctgatagacat	5	13	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:216273063C>A	uc002vfa.2	-	16	2652	c.2386G>T	c.(2386-2388)GAT>TAT	p.D796Y	FN1_uc002vfb.2_Missense_Mutation_p.D796Y|FN1_uc002vfc.2_Missense_Mutation_p.D796Y|FN1_uc002vfd.2_Missense_Mutation_p.D796Y|FN1_uc002vfe.2_Missense_Mutation_p.D796Y|FN1_uc002vff.2_Missense_Mutation_p.D796Y|FN1_uc002vfg.2_Missense_Mutation_p.D796Y|FN1_uc002vfh.2_Missense_Mutation_p.D796Y|FN1_uc002vfi.2_Missense_Mutation_p.D796Y|FN1_uc002vfj.2_Missense_Mutation_p.D796Y	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	796	Fibronectin type-III 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCTCCCCATCCTCAGATATC	0.408													1	0	1.22574e-08	0.002299	1.49836e-08	24	67										A	216273063	C	A	216273063	3	1	96	1	0	0	0	0	1	0	0	0	5962	855	30	3	5171	3	FN1	2	216273063	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	59193	216273063	26926310	178	28654										
RNF25	64320	broad.mit.edu	37	chr2	219532976	219532976	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttcacctctgctgggacctGaagcaccagagtgaagcaga	11	12	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219532976G>A	uc002vit.2	-	3	293	c.205C>T	c.(205-207)CAG>TAG	p.Q69*	RNF25_uc010fvw.2_5'UTR	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	69	RWD.				positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGGGACCTGAAGCACCAGA	0.547													0	0	0	0.00333	0	26	56										A	219532976	G	A	219532976	4	1	96	1	0	0	0	0	0	1	0	0	13485	1299	45	1	1206	1	RNF25	2	219532976	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3259913	219532976	23666397	179	28655										
TTLL4	9654	broad.mit.edu	37	chr2	219603658	219603658	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttctgtaccaagcgtatcaGcattcacctccttgcctcac	5	16	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219603658G>A	uc002viy.2	+	3	1629	c.1259G>A	c.(1258-1260)AGC>AAC	p.S420N	TTLL4_uc010zkl.1_Missense_Mutation_p.S255N|TTLL4_uc010fvx.2_Missense_Mutation_p.S420N	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	420					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AAGCGTATCAGCATTCACCTC	0.532													0	0	0	0.007291	0	29	95										A	219603658	G	A	219603658	3	1	96	1	0	0	0	0	1	0	0	0	16726	971	34	2	1261	2	TTLL4	2	219603658	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	70682	219603658	23595715	180	28656										
WNT6	7475	broad.mit.edu	37	chr2	219738481	219738481	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggagagcgtgcagctcgaaGagaactgcctgtgccgcttc	14	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219738481G>C	uc002vjc.1	+	4	1227	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	338					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGCTCGAAGAGAACTGCCT	0.711													0	0	0	0.004672	0	3	14										C	219738481	G	C	219738481	3	2	96	1	0	0	0	0	1	0	0	0	17390	943	33	1	1026	1	WNT6	2	219738481	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	134823	219738481	23460892	181	28657										
IHH	3549	broad.mit.edu	37	chr2	219920403	219920403	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcgatgacctggaaggctctCagcctgtgaggctcgcggtc	14	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:219920403C>T	uc002vjo.1	-	3	762	c.762G>A	c.(760-762)CTG>CTA	p.L254L		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	254					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAGGCTCTCAGCCTGTGAG	0.652													0	0	0	0.007413	0	20	25										T	219920403	C	T	219920403	2	4	96	1	0	0	0	0	0	0	0	1	7607	813	29	1		1	IHH	2	219920403	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	181922	219920403	23278970	182	28658										
OBSL1	23363	broad.mit.edu	37	chr2	220435169	220435170	+	Frame_Shift_Ins	INS	-	-	TGCT													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgtagcagcggaacttggcgINStgcttgccctcgttcaccca							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:220435169_220435170insTGCT	uc010fwk.2	-	1	842_843	c.785_786insAGCA	c.(784-786)CACfs	p.H262fs	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Frame_Shift_Ins_p.H262fs|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	262	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GGAACTTGGCGTGCTTGCCCTC	0.723																		19	89	---	---								TGCT	220435170	-	TGCT	220435169	7	5	96	1	0	1	1	0	0	0	0	0	10813	1136	40	0	5140	0	OBSL1	2	220435169	Frame_Shift_Ins	INS	-	TCGA-G2-A2EO-01A-11D-A17V-08	514766	220435169	22764204	183	28659										
PAX3	5077	broad.mit.edu	37	chr2	223065952	223065952	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaacgtgttcaaaaggatttGaaaccaactattggaggaag	11	5	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:223065952G>C	uc002vmt.1	-	10	1825	c.1459C>G	c.(1459-1461)CAA>GAA	p.Q487E	PAX3_uc002vmy.1_3'UTR|PAX3_uc002vmv.1_3'UTR|PAX3_uc002vmw.1_Missense_Mutation_p.F404L|PAX3_uc002vmx.1_3'UTR	NM_181459	NP_852124	P23760	PAX3_HUMAN	paired box 3 isoform PAX3e	Error:Variant_position_missing_in_P23760_after_alignment					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAAAGGATTTGAAACCAACTA	0.408			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						0	0	0	0.000978	0	10	43										C	223065952	G	C	223065952	3	2	96	1	0	0	0	0	1	0	0	0	11480	1299	45	1	62	1	PAX3	2	223065952	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2630783	223065952	20133421	184	28660										
DOCK10	55619	broad.mit.edu	37	chr2	225642870	225642870	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctaccttgttggaatcctgGattatcttcacattgtctgc	7	10	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:225642870G>C	uc010fwz.1	-	51	6026	c.5787C>G	c.(5785-5787)ATC>ATG	p.I1929M	DOCK10_uc002vob.2_Missense_Mutation_p.I1923M|DOCK10_uc002voa.2_Missense_Mutation_p.I585M	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1929	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGGAATCCTGGATTATCTTCA	0.353													0	0	0	0.004482	0	8	30										C	225642870	G	C	225642870	3	2	96	1	0	0	0	0	1	0	0	0	4685	1164	41	1	797	1	DOCK10	2	225642870	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2576918	225642870	17556503	185	28661										
COL4A3	1285	broad.mit.edu	37	chr2	228174028	228174028	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctggaaaggattttcattCatcatggtgaggagaaaagg	12	5	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:228174028C>T	uc002vom.1	+	50	4911	c.4749C>T	c.(4747-4749)TTC>TTT	p.F1583F	COL4A3_uc002von.1_Silent_p.F1583F|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'UTR	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1583	Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GATTTTCATTCATCATGGTGA	0.473													0	0	0	0.001168	0	5	22										T	228174028	C	T	228174028	2	4	96	1	0	0	0	0	0	0	0	1	3691	825	29	1		1	COL4A3	2	228174028	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2531158	228174028	15025345	186	28662										
SPHKAP	80309	broad.mit.edu	37	chr2	228883230	228883230	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agattgttgatgacaagactCgtgttgtgtgaattgctaag	12	4	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:228883230C>T	uc002vpq.2	-	7	2387	c.2340G>A	c.(2338-2340)ACG>ACA	p.T780T	SPHKAP_uc002vpp.2_Silent_p.T780T|SPHKAP_uc010zlx.1_Silent_p.T780T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	780						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGACAAGACTCGTGTTGTGTG	0.502													0	0	0	0.00361	0	46	124										T	228883230	C	T	228883230	2	4	96	1	0	0	0	0	0	0	0	1	15047	871	31	1		1	SPHKAP	2	228883230	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	709202	228883230	14316143	187	28663										
GPR55	9290	broad.mit.edu	37	chr2	231775629	231775629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgtagggttttcatcagctCgttgacaccgtcaaacaggc	10	11	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:231775629C>T	uc002vrg.2	-	2	242	c.49G>A	c.(49-51)GAG>AAG	p.E17K	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.E17K	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	17	Extracellular (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		TTCATCAGCTCGTTGACACCG	0.527													0	0	0	0.004007	0	17	75										T	231775629	C	T	231775629	3	4	96	1	0	0	0	0	1	0	0	0	6699	893	31	1	914	1	GPR55	2	231775629	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2892399	231775629	11423744	188	28664										
DGKD	8527	broad.mit.edu	37	chr2	234343105	234343105	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttggattgcagcattaaagaCtgtgcagaacagggagcact	12	7	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:234343105C>T	uc002vui.1	+	4	440	c.428C>T	c.(427-429)ACT>ATT	p.T143I	DGKD_uc002vuj.1_Missense_Mutation_p.T99I|DGKD_uc010fyh.1_Missense_Mutation_p.T10I|DGKD_uc002vuk.1_Missense_Mutation_p.T10I	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	143	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCATTAAAGACTGTGCAGAAC	0.443													0	0	0	0.00245	0	15	93										T	234343105	C	T	234343105	3	4	96	1	0	0	0	0	1	0	0	0	4467	565	20	2	466	2	DGKD	2	234343105	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2567476	234343105	8856268	189	28665										
GPC1	2817	broad.mit.edu	37	chr2	241404929	241404929	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtgacggcctggccaaccaGatcaacaaccccgaggtgga	13	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:241404929G>C	uc002vyw.3	+	8	1529	c.1308G>C	c.(1306-1308)CAG>CAC	p.Q436H		NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	436					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		TGGCCAACCAGATCAACAACC	0.627													0	0	0	0.000248	0	4	42										C	241404929	G	C	241404929	3	2	96	1	0	0	0	0	1	0	0	0	6597	933	33	1	1338	1	GPC1	2	241404929	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7061824	241404929	1794444	190	28666										
SEPT2	4735	broad.mit.edu	37	chr2	242285646	242285646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgaaaacttccgttctgagaGactcaagagaggcggcaggt	13	8	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:242285646G>C	uc002wbc.2	+	11	1329	c.908G>C	c.(907-909)AGA>ACA	p.R303T	SEPT2_uc002wbd.2_Missense_Mutation_p.R303T|SEPT2_uc002wbf.2_Missense_Mutation_p.R303T|SEPT2_uc002wbg.2_Missense_Mutation_p.R303T|SEPT2_uc002wbh.2_Missense_Mutation_p.R313T|SEPT2_uc010zop.1_Missense_Mutation_p.R338T	NM_001008491	NP_001008491	Q15019	SEPT2_HUMAN	septin 2	303					cell division|mitosis	actin cytoskeleton|cleavage furrow|condensed chromosome kinetochore|midbody|nucleolus|septin complex|spindle	GTP binding			central_nervous_system(1)	1		all_cancers(19;7.62e-41)|all_epithelial(40;1.71e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.24e-34)|all cancers(36;7.15e-32)|OV - Ovarian serous cystadenocarcinoma(60;1.21e-15)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;3.16e-06)|Lung(119;7.81e-05)|LUSC - Lung squamous cell carcinoma(224;0.000742)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0889)		CGTTCTGAGAGACTCAAGAGA	0.517													0	0	0	0.008291	0	11	24										C	242285646	G	C	242285646	3	2	96	1	0	0	0	0	1	0	0	0	14064	942	33	1	942	1	SEPT2	2	242285646	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	880717	242285646	913727	191	28667										
PDCD1	5133	broad.mit.edu	37	chr2	242794494	242794494	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggggtgggctgtgggcacttCtgcccttctctctggaaggg	17	10	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr2:242794494C>T	uc002wcq.3	-	3	516	c.448G>A	c.(448-450)GAA>AAA	p.E150K	PDCD1_uc010fzs.2_Intron|PDCD1_uc010fzt.2_RNA	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	150	Extracellular (Potential).				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GTGGGCACTTCTGCCCTTCTC	0.677													0	0	0	0.00499	0	15	25										T	242794494	C	T	242794494	3	4	96	1	0	0	0	0	1	0	0	0	11615	922	32	1	430	1	PDCD1	2	242794494	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	508848	242794494	404879	192	28668										
EDEM1	9695	broad.mit.edu	37	chr3	5246762	5246762	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atttttgcaggcaatgtcgtGaacattcagacgggccactg	11	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:5246762G>C	uc003bqi.2	+	6	1185	c.1053G>C	c.(1051-1053)GTG>GTC	p.V351V	EDEM1_uc011asz.1_Silent_p.V129V|EDEM1_uc003bqh.2_Silent_p.V351V	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	351	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GCAATGTCGTGAACATTCAGA	0.517													0	0	0	0.00361	0	60	76										C	5246762	G	C	5246762	2	2	96	1	0	0	0	0	0	0	0	1	4911	1277	45	1		1	EDEM1	3	5246762	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		5246762	192775668	193	28669										
C3orf24	115795	broad.mit.edu	37	chr3	10146088	10146088	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taatgattttgcaaaaggctGacttgtctgaaactctgaaa	8	6	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:10146088G>A	uc003buz.2	-	2	596	c.371C>T	c.(370-372)TCA>TTA	p.S124L	C3orf24_uc003bva.1_Missense_Mutation_p.S124L	NM_173472	NP_775743	Q96PS1	CC024_HUMAN	hypothetical protein LOC115795	124											0				OV - Ovarian serous cystadenocarcinoma(96;0.196)		GCAAAAGGCTGACTTGTCTGA	0.522													0	0	0	0.00278	0	23	173										A	10146088	G	A	10146088	3	1	96	1	0	0	0	0	1	0	0	0	2217	1294	45	1	166	1	C3orf24	3	10146088	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4899326	10146088	187876342	194	28670										
PPARG	5468	broad.mit.edu	37	chr3	12458253	12458253	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgatgggagaagataaaatCaagttcaaacacatcacccc	7	9	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:12458253C>G	uc003bwx.2	+	6	961	c.870C>G	c.(868-870)ATC>ATG	p.I290M	PPARG_uc003bwr.2_Missense_Mutation_p.I262M|PPARG_uc003bws.2_Missense_Mutation_p.I262M|PPARG_uc003bwu.2_Missense_Mutation_p.I262M|PPARG_uc003bwv.2_Intron|PPARG_uc010hea.1_RNA	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	290					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	AAGATAAAATCAAGTTCAAAC	0.473			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						0	0	0	0.00499	0	17	27										G	12458253	C	G	12458253	3	3	96	1	0	0	0	0	1	0	0	0	12299	816	29	1	892	1	PPARG	3	12458253	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2312165	12458253	185564177	195	28671										
ANKRD28	23243	broad.mit.edu	37	chr3	15762601	15762601	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attatagcaggctacatgaaGaggtgtatttccataggcat	10	6	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:15762601G>C	uc003caj.1	-	8	870	c.727C>G	c.(727-729)CTT>GTT	p.L243V	ANKRD28_uc003cai.1_Missense_Mutation_p.L89V|ANKRD28_uc011avz.1_Missense_Mutation_p.L89V|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.L273V|ANKRD28_uc003cam.2_Missense_Mutation_p.L276V	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	243	ANK 7.					nucleoplasm	protein binding			breast(1)	1						GCTACATGAAGAGGTGTATTT	0.328													0	0	0	0.00361	0	59	471										C	15762601	G	C	15762601	3	2	96	1	0	0	0	0	1	0	0	0	656	942	33	1	2518	1	ANKRD28	3	15762601	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3304348	15762601	182259829	196	28672										
TRANK1	9881	broad.mit.edu	37	chr3	36899292	36899292	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgttccaggccaagagcaGagagtcgttcttcttaatcc	9	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:36899292G>A	uc003cgj.2	-	3	441	c.139C>T	c.(139-141)CTG>TTG	p.L47L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	597					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GCCAAGAGCAGAGAGTCGTTC	0.532													0	0	0	0.002836	0	34	213										A	36899292	G	A	36899292	2	1	96	1	0	0	0	0	0	0	0	1	16451	933	33	1		1	TRANK1	3	36899292	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	21136691	36899292	161123138	197	28673										
LRRFIP2	9209	broad.mit.edu	37	chr3	37151043	37151043	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggcacttctcagcagaccaGaatttgcagtaggagaggcc	12	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:37151043G>A	uc003cgp.2	-	12	1007	c.584C>T	c.(583-585)TCT>TTT	p.S195F	LRRFIP2_uc011ayf.1_Intron|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	195	DVL3-binding.|Ser-rich.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						CAGCAGACCAGAATTTGCAGT	0.438													0	0	0	0.00361	0	48	75										A	37151043	G	A	37151043	3	1	96	1	0	0	0	0	1	0	0	0	9028	942	33	1	1653	1	LRRFIP2	3	37151043	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	251751	37151043	160871387	198	28674										
SCN10A	6336	broad.mit.edu	37	chr3	38739903	38739903	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgttgaagagggcaggcaggGacatcatgagggcaaagagc	17	6	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:38739903G>T	uc003ciq.2	-	27	4808	c.4808C>A	c.(4807-4809)TCC>TAC	p.S1603Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1603	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCAGGCAGGGACATCATGAG	0.562													1	0	5.61819e-17	0.005443	7.09044e-17	27	124										T	38739903	G	T	38739903	3	4	96	1	0	0	0	0	1	0	0	0	13912	1174	41	3	1066	3	SCN10A	3	38739903	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1588860	38739903	159282527	199	28675										
SCN10A	6336	broad.mit.edu	37	chr3	38743465	38743465	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaactggttgattttgcccaGaattttcgtcttttcttcac	7	9	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:38743465G>C	uc003ciq.2	-	26	4522	c.4522C>G	c.(4522-4524)CTG>GTG	p.L1508V		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1508	IV.|Helical; Name=S2 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATTTTGCCCAGAATTTTCGTC	0.448													0	0	0	0.00245	0	14	94										C	38743465	G	C	38743465	3	2	96	1	0	0	0	0	1	0	0	0	13912	933	33	1	1356	1	SCN10A	3	38743465	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3562	38743465	159278965	200	28676										
SCN11A	11280	broad.mit.edu	37	chr3	38962667	38962667	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctaccagggcaaagatgctGaggcaaaagaaggtgaggat	14	7	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:38962667G>A	uc011ays.1	-	6	991	c.792C>T	c.(790-792)CTC>CTT	p.L264L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	264	Helical; Name=S5 of repeat I; (By similarity).|I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CAAAGATGCTGAGGCAAAAGA	0.498													0	0	0	0.002836	0	34	252										A	38962667	G	A	38962667	2	1	96	1	0	0	0	0	0	0	0	1	13913	1277	45	1		1	SCN11A	3	38962667	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	219202	38962667	159059763	201	28677										
ENTPD3	956	broad.mit.edu	37	chr3	40457535	40457535	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gctatggccggaatgaggctGagaagaagtttctggcaatg	15	6	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:40457535G>C	uc003ckd.3	+	7	894	c.802G>C	c.(802-804)GAG>CAG	p.E268Q	ENTPD3_uc010hhy.2_Missense_Mutation_p.E268Q|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	268	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GAATGAGGCTGAGAAGAAGTT	0.552													0	0	0	0.00499	0	18	36										C	40457535	G	C	40457535	3	2	96	1	0	0	0	0	1	0	0	0	5140	1291	45	1	824	1	ENTPD3	3	40457535	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1494868	40457535	157564895	202	28678										
CSPG5	10675	broad.mit.edu	37	chr3	47619161	47619161	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agctggaagggcctgggcatCgccgctgcccgcctctgcgg	16	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:47619161C>T	uc003crp.3	-	2	531	c.355G>A	c.(355-357)GAT>AAT	p.D119N	CSPG5_uc003crn.2_5'UTR|CSPG5_uc003cro.3_Missense_Mutation_p.D119N|CSPG5_uc011bbb.1_5'UTR	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	119	Extracellular (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCTGGGCATCGCCGCTGCCC	0.692													0	0	0	0.00499	0	16	82										T	47619161	C	T	47619161	3	4	96	1	0	0	0	0	1	0	0	0	3961	884	31	1	1280	1	CSPG5	3	47619161	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7161626	47619161	150403269	203	28679										
COL7A1	1294	broad.mit.edu	37	chr3	48612779	48612779	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccccagcctcaccctctctCctggccttcctgcctctccc	4	25	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48612779C>T	uc003ctz.2	-	73	6174	c.6173G>A	c.(6172-6174)GGA>GAA	p.G2058E		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2058	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CACCCTCTCTCCTGGCCTTCC	0.697													0	0	0	0.007291	0	26	30										T	48612779	C	T	48612779	3	4	96	1	0	0	0	0	1	0	0	0	3704	855	30	1	2845	1	COL7A1	3	48612779	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	993618	48612779	149409651	204	28680										
CELSR3	1951	broad.mit.edu	37	chr3	48697852	48697852	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtcacggtgacactggctGaggcagagagtgggggtgag	19	7	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48697852G>A	uc003cul.2	-	1	2497	c.2216C>T	c.(2215-2217)TCA>TTA	p.S739L	CELSR3_uc003cuf.1_Missense_Mutation_p.S809L	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	739	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GACACTGGCTGAGGCAGAGAG	0.567													0	0	0	0.007835	0	34	53										A	48697852	G	A	48697852	3	1	96	1	0	0	0	0	1	0	0	0	3223	1294	45	1	7862	1	CELSR3	3	48697852	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	85073	48697852	149324578	205	28681										
CELSR3	1951	broad.mit.edu	37	chr3	48698805	48698805	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcgttgcggtcggctactgtCacggccaccatcgtggtggc	14	13	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48698805C>G	uc003cul.2	-	1	1544	c.1263G>C	c.(1261-1263)GTG>GTC	p.V421V	CELSR3_uc003cuf.1_Silent_p.V491V	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	421	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGGCTACTGTCACGGCCACCA	0.662													0	0	0	0.004289	0	36	53										G	48698805	C	G	48698805	2	3	96	1	0	0	0	0	0	0	0	1	3223	813	29	1		1	CELSR3	3	48698805	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	953	48698805	149323625	206	28682										
PRKAR2A	5576	broad.mit.edu	37	chr3	48820513	48820513	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaacatggcatcgagaacttGagaaagctgttcctgcaggg	12	8	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:48820513G>T	uc010hki.1	-	5	689	c.448C>A	c.(448-450)CAA>AAA	p.Q150K	PRKAR2A_uc003cux.1_Missense_Mutation_p.Q150K|PRKAR2A_uc003cuy.1_Missense_Mutation_p.Q150K	NM_004157	NP_004148	P13861	KAP2_HUMAN	cAMP-dependent protein kinase, regulatory	150	cAMP 1.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		TCGAGAACTTGAGAAAGCTGT	0.383													1	0	4.68919e-08	0.008291	5.70789e-08	10	67										T	48820513	G	T	48820513	3	4	96	1	0	0	0	0	1	0	0	0	12505	1299	45	3	794	3	PRKAR2A	3	48820513	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	121708	48820513	149201917	207	28683										
WDR6	11180	broad.mit.edu	37	chr3	49049462	49049462	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accctctcttcagcctgcctGattggagacgcctggaagga	11	13	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:49049462G>A	uc003cvj.2	+	2	723	c.585G>A	c.(583-585)CTG>CTA	p.L195L	WDR6_uc011bbx.1_Silent_p.L66L|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Silent_p.L139L|WDR6_uc011bbz.1_Silent_p.L114L	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	165	WD 2.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CAGCCTGCCTGATTGGAGACG	0.567													0	0	0	0.001168	0	6	50										A	49049462	G	A	49049462	2	1	96	1	0	0	0	0	0	0	0	1	17307	1277	45	1		1	WDR6	3	49049462	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	228949	49049462	148972968	208	28684										
SEMA3F	6405	broad.mit.edu	37	chr3	50211515	50211515	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagcctccccacagcgcatcGaggaatgcgtgctctcaggc	11	16	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:50211515G>A	uc003cyj.2	+	4	502	c.304G>A	c.(304-306)GAG>AAG	p.E102K	SEMA3F_uc003cyk.2_Missense_Mutation_p.E102K	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	102	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		ACAGCGCATCGAGGAATGCGT	0.627													0	0	0	0.004878	0	38	37										A	50211515	G	A	50211515	3	1	96	1	0	0	0	0	1	0	0	0	14029	1059	37	1	314	1	SEMA3F	3	50211515	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1162053	50211515	147810915	209	28685										
HYAL2	8692	broad.mit.edu	37	chr3	50357236	50357236	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attgcgggccacctcaacatCagggcagcggcctgtgtagc	13	13	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:50357236C>T	uc003czu.2	-	2	905	c.685G>A	c.(685-687)GAT>AAT	p.D229N	HYAL2_uc003czx.2_Missense_Mutation_p.D229N|HYAL2_uc003czv.2_Missense_Mutation_p.D229N|HYAL2_uc003czw.2_Missense_Mutation_p.D229N|HYAL2_uc010hlj.2_Missense_Mutation_p.D229N	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor	229						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	ACCTCAACATCAGGGCAGCGG	0.612													0	0	0	0.004007	0	17	32										T	50357236	C	T	50357236	3	4	96	1	0	0	0	0	1	0	0	0	7464	826	29	1	748	1	HYAL2	3	50357236	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	145721	50357236	147665194	210	28686										
NT5DC2	64943	broad.mit.edu	37	chr3	52558487	52558487	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccagacaataaaggtgccctCagcggatgtgggccatgtca	12	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:52558487C>T	uc003deo.2	-	14	1986	c.1562G>A	c.(1561-1563)TGA>TAA	p.*521*	NT5DC2_uc003dem.2_Silent_p.*391*|NT5DC2_uc003den.2_Silent_p.*558*|NT5DC2_uc010hmi.2_Silent_p.*533*|NT5DC2_uc010hmj.2_Silent_p.*337*|STAB1_uc003dej.2_3'UTR|STAB1_uc003del.2_3'UTR	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	521							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		AAGGTGCCCTCAGCGGATGTG	0.612													0	0	0	0.00361	0	98	110										T	52558487	C	T	52558487	2	4	96	1	0	0	0	0	0	0	0	1	10691	837	29	1		1	NT5DC2	3	52558487	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2201251	52558487	145463943	211	28687										
PBRM1	55193	broad.mit.edu	37	chr3	52643561	52643561	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagattgtggataagctcttGaatcagcaaagtcacatttg	9	6	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:52643561G>C	uc003des.2	-	16	2347	c.2335C>G	c.(2335-2337)CAA>GAA	p.Q779E	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.Q779E|PBRM1_uc003der.2_Missense_Mutation_p.Q747E|PBRM1_uc003det.2_Missense_Mutation_p.Q794E|PBRM1_uc003deu.2_Missense_Mutation_p.Q794E|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.Q779E|PBRM1_uc010hmk.1_Missense_Mutation_p.Q779E|PBRM1_uc003dey.2_Missense_Mutation_p.Q779E|PBRM1_uc003dez.1_Missense_Mutation_p.Q779E|PBRM1_uc003dfb.1_Missense_Mutation_p.Q692E|PBRM1_uc003dfa.1_Missense_Mutation_p.Q125E|PBRM1_uc003dfc.2_Missense_Mutation_p.Q146E	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	779					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.Q779*(3)		kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATAAGCTCTTGAATCAGCAAA	0.448			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.003755	0	36	43										C	52643561	G	C	52643561	3	2	96	1	0	0	0	0	1	0	0	0	11491	1299	45	1	2625	1	PBRM1	3	52643561	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	85074	52643561	145378869	212	28688										
PBRM1	55193	broad.mit.edu	37	chr3	52696218	52696218	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcgtcatctgcttctcctttCtgaacaaactcatttcttgt	4	12	6	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:52696218C>T	uc003des.2	-	4	471	c.459G>A	c.(457-459)CAG>CAA	p.Q153Q	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Silent_p.Q153Q|PBRM1_uc003der.2_Silent_p.Q153Q|PBRM1_uc003det.2_Silent_p.Q153Q|PBRM1_uc003deu.2_Silent_p.Q153Q|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.Q153Q|PBRM1_uc010hmk.1_Silent_p.Q153Q|PBRM1_uc003dey.2_Silent_p.Q153Q|PBRM1_uc003dez.1_Silent_p.Q153Q|PBRM1_uc003dfb.1_Silent_p.Q51Q	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	153					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CTTCTCCTTTCTGAACAAACT	0.418			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.001786	0	32	217										T	52696218	C	T	52696218	2	4	96	1	0	0	0	0	0	0	0	1	11491	912	32	1		1	PBRM1	3	52696218	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	52657	52696218	145326212	213	28689										
CACNA1D	776	broad.mit.edu	37	chr3	53783406	53783406	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcatcattgtagctttcttCatgatgaacatctttgtggg	8	7	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:53783406C>T	uc003dgv.3	+	27	3589	c.3426C>T	c.(3424-3426)TTC>TTT	p.F1142F	CACNA1D_uc003dgu.3_Silent_p.F1162F|CACNA1D_uc003dgy.3_Silent_p.F1142F|CACNA1D_uc003dgw.3_Silent_p.F809F|CACNA1D_uc003dgx.1_Silent_p.F290F	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1142	Helical; Name=S6 of repeat III; (Potential).|Dihydropyridine binding (By similarity).|III.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TAGCTTTCTTCATGATGAACA	0.418													0	0	0	0.002096	0	33	44										T	53783406	C	T	53783406	2	4	96	1	0	0	0	0	0	0	0	1	2541	825	29	1		1	CACNA1D	3	53783406	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1087188	53783406	144239024	214	28690										
ERC2	26059	broad.mit.edu	37	chr3	55733504	55733504	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtaatggtgatggtcatcatCatagttgtctgccatcaact	9	8	5	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:55733504C>T	uc003dhr.1	-	16	3005	c.2749G>A	c.(2749-2751)GAT>AAT	p.D917N	ERC2_uc003dhq.1_RNA	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	917	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		tggtCATCATCATAGTTGTCT	0.383													0	0	0	0.00361	0	121	193										T	55733504	C	T	55733504	3	4	96	1	0	0	0	0	1	0	0	0	5211	826	29	1	132	1	ERC2	3	55733504	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1950098	55733504	142288926	215	28691										
MAGI1	9223	broad.mit.edu	37	chr3	65342307	65342307	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcgggggacctcctctgctCcaggagtctctccagagacc	11	16	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:65342307C>T	uc003dmn.2	-	23	4661	c.4135G>A	c.(4135-4137)GAG>AAG	p.E1379K	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1408					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTCCTCTGCTCCAGGAGTCTC	0.726													0	0	0	0.002299	0	22	58										T	65342307	C	T	65342307	3	4	96	1	0	0	0	0	1	0	0	0	9190	864	30	1	257	1	MAGI1	3	65342307	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9608803	65342307	132680123	216	28692										
LRIG1	26018	broad.mit.edu	37	chr3	66434683	66434683	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgtcgtggggcgttttggtGaatgatggcaacactggaaa	15	5	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:66434683G>A	uc003dmx.2	-	14	1817	c.1803C>T	c.(1801-1803)TTC>TTT	p.F601F	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Silent_p.F221F|LRIG1_uc003dmw.2_Silent_p.F267F|LRIG1_uc010hnz.2_Silent_p.F317F|LRIG1_uc010hoa.2_Silent_p.F625F	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	601	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCGTTTTGGTGAATGATGGCA	0.547													0	0	0	0.00361	0	56	283										A	66434683	G	A	66434683	2	1	96	1	0	0	0	0	0	0	0	1	8944	1281	45	1		1	LRIG1	3	66434683	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1092376	66434683	131587747	217	28693										
LRIG1	26018	broad.mit.edu	37	chr3	66502041	66502041	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggatggtaccgctgtcaactCattattattgaggtacctgt	10	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:66502041C>T	uc003dmx.2	-	3	321	c.307G>A	c.(307-309)GAG>AAG	p.E103K	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Missense_Mutation_p.E103K	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	103	Extracellular (Potential).|LRR 2.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCTGTCAACTCATTATTATTG	0.438													0	0	0	0.00361	0	51	68										T	66502041	C	T	66502041	3	4	96	1	0	0	0	0	1	0	0	0	8944	835	29	1	3042	1	LRIG1	3	66502041	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	67358	66502041	131520389	218	28694										
GXYLT2	727936	broad.mit.edu	37	chr3	73016856	73016856	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caacgttcagagcactctatGaagcaatacgggatgtaagt	10	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:73016856G>A	uc003dpg.2	+	6	1135	c.1135G>A	c.(1135-1137)GAA>AAA	p.E379K		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	379	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						AGCACTCTATGAAGCAATACG	0.493													0	0	0	0.008291	0	9	38										A	73016856	G	A	73016856	3	1	96	1	0	0	0	0	1	0	0	0	6904	1291	45	1	1157	1	GXYLT2	3	73016856	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6514815	73016856	125005574	219	28695										
CGGBP1	8545	broad.mit.edu	37	chr3	88104904	88104904	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctttctcacattctgctcttCaaattctgccttcctcttgg	4	14	6	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:88104904C>T	uc003dqs.2	-	4	735	c.223G>A	c.(223-225)GAA>AAA	p.E75K	CGGBP1_uc003dqt.2_Missense_Mutation_p.E75K|CGGBP1_uc003dqu.2_Missense_Mutation_p.E75K	NM_001008390	NP_001008391	Q9UFW8	CGBP1_HUMAN	CGG triplet repeat binding protein 1	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding				0		Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00359)|Lung(72;0.00677)		TTCTGCTCTTCAAATTCTGCC	0.453													0	0	0	0.003163	0	15	112										T	88104904	C	T	88104904	3	4	96	1	0	0	0	0	1	0	0	0	3302	835	29	1	284	1	CGGBP1	3	88104904	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	15088048	88104904	109917526	220	28696										
TMEM45A	55076	broad.mit.edu	37	chr3	100277340	100277340	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcgtctttctgacaggcctCgttgccttcctagagttcct	9	13	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:100277340C>T	uc003dtz.1	+	4	808	c.495C>T	c.(493-495)CTC>CTT	p.L165L	TMEM45A_uc003dua.1_Silent_p.L181L	NM_018004	NP_060474	Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	165	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						TGACAGGCCTCGTTGCCTTCC	0.502													0	0	0	0.008361	0	32	178										T	100277340	C	T	100277340	2	4	96	1	0	0	0	0	0	0	0	1	16166	871	31	1		1	TMEM45A	3	100277340	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	12172436	100277340	97745090	221	28697										
GPR128	84873	broad.mit.edu	37	chr3	100413798	100413798	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggaaacctctccgagtactGaggaaatcacactctctgaa	8	11	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:100413798G>A	uc003duc.2	+	16	2615	c.2347G>A	c.(2347-2349)GAG>AAG	p.E783K	GPR128_uc011bhc.1_Missense_Mutation_p.E484K|GPR128_uc003dud.2_Missense_Mutation_p.E306K	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	783	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TCCGAGTACTGAGGAAATCAC	0.433													0	0	0	0.00499	0	18	69										A	100413798	G	A	100413798	3	1	96	1	0	0	0	0	1	0	0	0	6641	1291	45	1	2409	1	GPR128	3	100413798	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	136458	100413798	97608632	222	28698										
IMPG2	50939	broad.mit.edu	37	chr3	100961751	100961751	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgactggagatagggaaccaGctacaatatacaaaagtggt	11	6	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:100961751G>A	uc003duq.1	-	14	3006	c.2803C>T	c.(2803-2805)CTG>TTG	p.L935L	IMPG2_uc011bhe.1_Silent_p.L798L	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	935	Extracellular (Potential).|SEA 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TAGGGAACCAGCTACAATATA	0.403													0	0	0	0.003954	0	25	69										A	100961751	G	A	100961751	2	1	96	1	0	0	0	0	0	0	0	1	7729	985	34	2		2	IMPG2	3	100961751	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	547953	100961751	97060679	223	28699										
PHLDB2	90102	broad.mit.edu	37	chr3	111667878	111667878	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgctgatgctgttgccactGagcctgccacagctgtgctg	12	12	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:111667878G>A	uc010hqa.2	+	10	2998	c.2587G>A	c.(2587-2589)GAG>AAG	p.E863K	PHLDB2_uc003dyc.2_Missense_Mutation_p.E847K|PHLDB2_uc003dyd.2_Missense_Mutation_p.E820K|PHLDB2_uc003dyg.2_Missense_Mutation_p.E863K|PHLDB2_uc003dyh.2_Missense_Mutation_p.E820K|PHLDB2_uc003dyi.2_Intron	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	863						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGTTGCCACTGAGCCTGCCAC	0.478													0	0	0	0.004007	0	16	39										A	111667878	G	A	111667878	3	1	96	1	0	0	0	0	1	0	0	0	11852	1291	45	1	2706	1	PHLDB2	3	111667878	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10706127	111667878	86354552	224	28700										
GCET2	257144	broad.mit.edu	37	chr3	111851948	111851948	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctagacttacctgttttctCtcagcagagaatttcccatc	5	12	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:111851948C>G	uc003dys.1	-	1	170	c.20G>C	c.(19-21)AGA>ACA	p.R7T	GCET2_uc003dyt.1_5'UTR	NM_152785	NP_689998	Q8N6F7	GCET2_HUMAN	germinal center expressed transcript 2 isoform	7						mitochondrion					0						CCTGTTTTCTCTCAGCAGAGA	0.502													0	0	0	0.002836	0	30	169										G	111851948	C	G	111851948	3	3	96	1	0	0	0	0	1	0	0	0	6288	913	32	1	546	1	GCET2	3	111851948	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	184070	111851948	86170482	225	28701										
BTLA	151888	broad.mit.edu	37	chr3	112185019	112185019	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttacatttcttgccagtcttGagttcggtccaatgacagaa	8	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:112185019G>C	uc003dza.3	-	5	1009	c.806C>G	c.(805-807)TCA>TGA	p.S269*	BTLA_uc003dzb.3_Nonsense_Mutation_p.S221*	NM_181780	NP_861445	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated isoform 1	269	Cytoplasmic (Potential).				T cell costimulation		receptor activity				0		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TGCCAGTCTTGAGTTCGGTCC	0.418													0	0	0	0.004289	0	35	90										C	112185019	G	C	112185019	4	2	96	1	0	0	0	0	0	1	0	0	1558	1294	45	1	67	1	BTLA	3	112185019	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	333071	112185019	85837411	226	28702										
KIAA2018	205717	broad.mit.edu	37	chr3	113378767	113378767	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaggagtggcaaaggattctGattagcagcctgtatgatta	13	5	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:113378767G>C	uc003eam.2	-	7	2173	c.1762C>G	c.(1762-1764)CAG>GAG	p.Q588E	KIAA2018_uc003eal.2_Missense_Mutation_p.Q532E	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	588					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AAAGGATTCTGATTAGCAGCC	0.478													0	0	0	0.008871	0	21	102										C	113378767	G	C	113378767	3	2	96	1	0	0	0	0	1	0	0	0	8268	1299	45	1	4979	1	KIAA2018	3	113378767	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1193748	113378767	84643663	227	28703										
RABL3	285282	broad.mit.edu	37	chr3	120461334	120461334	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcccaacaccagtaccttCacccgatccagggacgccat	6	18	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:120461334C>T	uc003edx.2	-	1	51	c.21G>A	c.(19-21)GTG>GTA	p.V7V	GTF2E1_uc003edy.2_5'Flank|GTF2E1_uc003edz.3_5'Flank	NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	7	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		CCAGTACCTTCACCCGATCCA	0.567													0	0	0	0.004482	0	9	76										T	120461334	C	T	120461334	2	4	96	1	0	0	0	0	0	0	0	1	12972	813	29	1		1	RABL3	3	120461334	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7082567	120461334	77561096	228	28704										
SLC15A2	6565	broad.mit.edu	37	chr3	121630438	121630438	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggacaatcatctatctctCcttggtgtatgtgcttggcc	9	11	3	0	rs138471341		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:121630438C>G	uc003eep.2	+	4	506	c.353C>G	c.(352-354)TCC>TGC	p.S118C	SLC15A2_uc011bjn.1_Intron	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	118	Helical; (Potential).				protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding	p.S118F(1)		skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	ATCTATCTCTCCTTGGTGTAT	0.418													0	0	0	0.00333	0	22	30										G	121630438	C	G	121630438	3	3	96	1	0	0	0	0	1	0	0	0	14399	855	30	1	367	1	SLC15A2	3	121630438	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1169104	121630438	76391992	229	28705										
SLC41A3	54946	broad.mit.edu	37	chr3	125735707	125735707	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaggcagaccagcggcgtcaGataccgactatctgaaagga	13	10	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:125735707G>C	uc003eij.2	-	7	983	c.757C>G	c.(757-759)CTG>GTG	p.L253V	SLC41A3_uc003eii.2_Missense_Mutation_p.L227V|SLC41A3_uc003eil.2_Missense_Mutation_p.L253V|SLC41A3_uc003eik.2_Missense_Mutation_p.L217V|SLC41A3_uc011bkh.1_Missense_Mutation_p.L136V|SLC41A3_uc010hsd.1_Missense_Mutation_p.L268V	NM_001008485	NP_001008485	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3 isoform 1	253	Helical; (Potential).					integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(114;0.167)		AGCGGCGTCAGATACCGACTA	0.582													0	0	0	0.004672	0	3	41										C	125735707	G	C	125735707	3	2	96	1	0	0	0	0	1	0	0	0	14631	933	33	1	888	1	SLC41A3	3	125735707	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4105269	125735707	72286723	230	28706										
ZXDC	79364	broad.mit.edu	37	chr3	126193905	126193905	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcggcgcacacctcgcacttGaacaggctctcctgctcgtg	10	16	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:126193905G>C	uc003eiv.2	-	1	858	c.804C>G	c.(802-804)TTC>TTG	p.F268L	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.F268L	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	268	C2H2-type 4.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		CCTCGCACTTGAACAGGCTCT	0.627													0	0	0	0.000248	0	3	13										C	126193905	G	C	126193905	3	2	96	1	0	0	0	0	1	0	0	0	18249	1281	45	1	1818	1	ZXDC	3	126193905	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	458198	126193905	71828525	231	28707										
IFT122	55764	broad.mit.edu	37	chr3	129214429	129214429	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttgaaatgtacaccgacctCtgcatgtttgagtatgccaa	8	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:129214429C>A	uc003emm.2	+	18	2393	c.2187C>A	c.(2185-2187)CTC>CTA	p.L729L	IFT122_uc003eml.2_Silent_p.L780L|IFT122_uc003emn.2_Silent_p.L670L|IFT122_uc003emo.2_Silent_p.L618L|IFT122_uc003emp.2_Silent_p.L579L|IFT122_uc010htc.2_Silent_p.L721L|IFT122_uc011bky.1_Silent_p.L520L|IFT122_uc003emq.2_Silent_p.L569L|IFT122_uc003emr.2_Silent_p.L481L|IFT122_uc011bla.1_Silent_p.L502L|IFT122_uc010hte.2_Intron|IFT122_uc003ems.2_Silent_p.L110L|IFT122_uc011bkx.1_Silent_p.L569L|IFT122_uc010htd.1_Silent_p.L208L	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	729					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						ACACCGACCTCTGCATGTTTG	0.527													1	0	2.27731e-05	0.001882	2.73277e-05	20	48										A	129214429	C	A	129214429	2	1	96	1	0	0	0	0	0	0	0	1	7555	900	32	3		3	IFT122	3	129214429	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3020524	129214429	68808001	232	28708										
IFT122	55764	broad.mit.edu	37	chr3	129231193	129231193	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catcgtcctgaaactcttttCaacatctccaggttcctgct	5	14	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:129231193C>G	uc003emm.2	+	24	3131	c.2925C>G	c.(2923-2925)TTC>TTG	p.F975L	IFT122_uc003eml.2_Missense_Mutation_p.F1026L|IFT122_uc003emn.2_Missense_Mutation_p.F916L|IFT122_uc003emo.2_Missense_Mutation_p.F865L|IFT122_uc003emp.2_Missense_Mutation_p.F825L|IFT122_uc010htc.2_Missense_Mutation_p.F968L|IFT122_uc011bky.1_Missense_Mutation_p.F766L|IFT122_uc003emq.2_Missense_Mutation_p.F815L|IFT122_uc003emr.2_Missense_Mutation_p.F728L|IFT122_uc011bla.1_Missense_Mutation_p.F749L|IFT122_uc010hte.2_Missense_Mutation_p.F301L|IFT122_uc003ems.2_Missense_Mutation_p.F357L|IFT122_uc011bkx.1_Missense_Mutation_p.F816L	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	975					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						AAACTCTTTTCAACATCTCCA	0.537													0	0	0	0.00361	0	45	201										G	129231193	C	G	129231193	3	3	96	1	0	0	0	0	1	0	0	0	7555	825	29	1	3179	1	IFT122	3	129231193	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	16764	129231193	68791237	233	28709										
PLXND1	23129	broad.mit.edu	37	chr3	129290635	129290635	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcgcacacacacaggcaccgGagccggcagggccccctcag	13	18	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:129290635G>C	uc003emx.2	-	16	3230	c.3130C>G	c.(3130-3132)CCG>GCG	p.P1044A		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1044	Extracellular (Potential).|IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						ACAGGCACCGGAGCCGGCAGG	0.662													0	0	0	0.000602	0	5	27										C	129290635	G	C	129290635	3	2	96	1	0	0	0	0	1	0	0	0	12127	1174	41	1	2731	1	PLXND1	3	129290635	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	59442	129290635	68731795	234	28710										
MSL2	55167	broad.mit.edu	37	chr3	135913868	135913868	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggcaagagcctgttaatctCagtaaacgccttggggtctc	11	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:135913868C>T	uc003eqx.1	-	1	821	c.88G>A	c.(88-90)GAG>AAG	p.E30K	MSL2_uc011bmb.1_5'Flank	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	30					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1						CTGTTAATCTCAGTAAACGCC	0.493													0	0	0	0.00361	0	99	160										T	135913868	C	T	135913868	3	4	96	1	0	0	0	0	1	0	0	0	9878	835	29	1	1653	1	MSL2	3	135913868	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6623233	135913868	62108562	235	28711										
ESYT3	83850	broad.mit.edu	37	chr3	138195290	138195290	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgtgattatttaggtactGattgacttatcaaaagaaga	8	3	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:138195290G>A	uc003esk.2	+	22	2806	c.2580G>A	c.(2578-2580)CTG>CTA	p.L860L		NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	860	C2 3.					integral to membrane|plasma membrane					0						TTTAGGTACTGATTGACTTAT	0.353													0	0	0	0.001168	0	4	55										A	138195290	G	A	138195290	2	1	96	1	0	0	0	0	0	0	0	1	5266	1277	45	1		1	ESYT3	3	138195290	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2281422	138195290	59827140	236	28712										
MRPS22	56945	broad.mit.edu	37	chr3	139063001	139063001	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaccgctaccttgctctttcGagatggggctgccacgccgc	11	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:139063001G>C	uc003etb.2	+	1	141	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.E45Q|MRPS22_uc003ete.2_5'Flank	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	45						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						TTGCTCTTTCGAGATGGGGCT	0.627													0	0	0	0.001168	0	6	23										C	139063001	G	C	139063001	3	2	96	1	0	0	0	0	1	0	0	0	9833	1059	37	1	135	1	MRPS22	3	139063001	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	867711	139063001	58959429	237	28713										
COPB2	9276	broad.mit.edu	37	chr3	139092111	139092111	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atttcacaactgcccatatcCtttactgccagtggcaatct	5	13	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:139092111C>T	uc003etf.3	-	9	1168	c.1038G>A	c.(1036-1038)AAG>AAA	p.K346K	COPB2_uc011bmv.1_Silent_p.K317K|COPB2_uc010hui.2_Silent_p.K317K	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	346					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TGCCCATATCCTTTACTGCCA	0.438													0	0	0	0.004482	0	7	104										T	139092111	C	T	139092111	2	4	96	1	0	0	0	0	0	0	0	1	3729	680	24	2		2	COPB2	3	139092111	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	29110	139092111	58930319	238	28714										
SPSB4	92369	broad.mit.edu	37	chr3	140785627	140785627	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagtcaccatgcgctacatCaacggccttgaccgtaagtt	9	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:140785627C>G	uc003ett.2	+	2	935	c.681C>G	c.(679-681)ATC>ATG	p.I227M	SPSB4_uc010hum.2_Missense_Mutation_p.I227M	NM_080862	NP_543138	Q96A44	SPSB4_HUMAN	splA/ryanodine receptor domain and SOCS box	227	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding				0						TGCGCTACATCAACGGCCTTG	0.637													0	0	0	0.008871	0	14	37										G	140785627	C	G	140785627	3	3	96	1	0	0	0	0	1	0	0	0	15114	816	29	1	683	1	SPSB4	3	140785627	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1693516	140785627	57236803	239	28715										
ATR	545	broad.mit.edu	37	chr3	142168301	142168301	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggagtccaaccaagatacatCtggcatagtaagttttcatc	8	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:142168301C>G	uc003eux.3	-	47	8027	c.7905G>C	c.(7903-7905)CAG>CAC	p.Q2635H	XRN1_uc003eus.2_5'Flank|XRN1_uc003eut.2_5'Flank|XRN1_uc003euu.2_5'Flank|XRN1_uc003euw.2_5'Flank|XRN1_uc011bnh.1_5'Flank|ATR_uc003euy.1_3'UTR	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2635	FATC.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CAAGATACATCTGGCATAGTA	0.333								Other_conserved_DNA_damage_response_genes					0	0	0	0.00245	0	12	72										G	142168301	C	G	142168301	3	3	96	1	0	0	0	0	1	0	0	0	1204	912	32	1	33	1	ATR	3	142168301	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1382674	142168301	55854129	240	28716										
P2RY13	53829	broad.mit.edu	37	chr3	151046539	151046539	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agggtgccaggtgtgagtcaGagaggattttgaaaggaagc	17	4	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:151046539G>C	uc003eyv.2	-	2	326	c.305C>G	c.(304-306)TCT>TGT	p.S102C	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	102	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			GTGTGAGTCAGAGAGGATTTT	0.468													0	0	0	0.001882	0	21	36										C	151046539	G	C	151046539	3	2	96	1	0	0	0	0	1	0	0	0	11350	942	33	1	763	1	P2RY13	3	151046539	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8878238	151046539	46975891	241	28717										
IGSF10	285313	broad.mit.edu	37	chr3	151154669	151154669	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtcaggcatctcccatgtGatttctggcttgggaactcc	11	11	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:151154669G>A	uc011bod.1	-	6	7680	c.7680C>T	c.(7678-7680)ATC>ATT	p.I2560I	IGSF10_uc011bob.1_Silent_p.I587I|IGSF10_uc011boc.1_Silent_p.I539I	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2560	Ig-like C2-type 12.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTCCCATGTGATTTCTGGCT	0.522													0	0	0	0.00245	0	15	57										A	151154669	G	A	151154669	2	1	96	1	0	0	0	0	0	0	0	1	7597	1280	45	1		1	IGSF10	3	151154669	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	108130	151154669	46867761	242	28718										
MME	4311	broad.mit.edu	37	chr3	154834674	154834674	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taggtgcttcttggacagctGaaaaagctattgcacaactg	10	8	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:154834674G>A	uc010hvr.1	+	7	764	c.553G>A	c.(553-555)GAA>AAA	p.E185K	MME_uc003fab.1_Missense_Mutation_p.E185K|MME_uc003fac.1_Missense_Mutation_p.E185K|MME_uc003fad.1_Missense_Mutation_p.E185K|MME_uc003fae.1_Missense_Mutation_p.E185K	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	185	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTGGACAGCTGAAAAAGCTAT	0.284													0	0	0	0.001368	0	12	35										A	154834674	G	A	154834674	3	1	96	1	0	0	0	0	1	0	0	0	9645	1291	45	1	575	1	MME	3	154834674	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3680005	154834674	43187756	243	28719										
GMPS	8833	broad.mit.edu	37	chr3	155633963	155633963	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacaatgacacagagctcatCagaaagttgagagaggaggt	12	7	2	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:155633963C>T	uc003faq.2	+	9	1529	c.1194C>T	c.(1192-1194)ATC>ATT	p.I398I	GMPS_uc011bom.1_Silent_p.I299I	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	398					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CAGAGCTCATCAGAAAGTTGA	0.393			T	MLL	AML								0	0	0	0.007835	0	36	84										T	155633963	C	T	155633963	2	4	96	1	0	0	0	0	0	0	0	1	6498	816	29	1		1	GMPS	3	155633963	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	799289	155633963	42388467	244	28720										
SI	6476	broad.mit.edu	37	chr3	164735823	164735823	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctcttccagagccatgtaaTagggatgaaatccataggaa	9	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:164735823T>C	uc003fei.2	-	29	3517	c.3455A>G	c.(3454-3456)TAT>TGT	p.Y1152C		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1152	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AGCCATGTAATAGGGATGAAA	0.313										HNSCC(35;0.089)			0	0	0	0.004482	0	7	64										C	164735823	T	C	164735823	3	2	96	1	0	0	0	0	1	0	0	0	14297	1406	49	5	2108	5	SI	3	164735823	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	9101860	164735823	33286607	245	28721										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.001523	0	20	57										A	178936091	G	A	178936091	3	1	96	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	14200268	178936091	19086339	246	28722										
MCCC1	56922	broad.mit.edu	37	chr3	182763328	182763328	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccataataaactccacagtcCctaaaaggtaaaaaacaatg	4	10	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:182763328C>T	uc003fle.2	-	10	1093	c.956G>A	c.(955-957)GGG>GAG	p.G319E	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.G202E|MCCC1_uc003flg.2_Missense_Mutation_p.G210E|MCCC1_uc011bqp.1_Missense_Mutation_p.G272E|MCCC1_uc011bqq.1_Missense_Mutation_p.G210E	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	319	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CTCCACAGTCCCTAAAAGGTA	0.363													0	0	0	0.001368	0	13	54										T	182763328	C	T	182763328	3	4	96	1	0	0	0	0	1	0	0	0	9374	637	22	2	1261	2	MCCC1	3	182763328	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3827237	182763328	15259102	247	28723										
MCF2L2	23101	broad.mit.edu	37	chr3	182923668	182923668	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcaggggtaacctacctttGatattattttgttgttccat	8	7	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:182923668G>C	uc003fli.1	-	25	2970	c.2880C>G	c.(2878-2880)ATC>ATG	p.I960M		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	960					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCTACCTTTGATATTATTTT	0.368													0	0	0	0.001368	0	10	21										C	182923668	G	C	182923668	3	2	96	1	0	0	0	0	1	0	0	0	9380	1280	45	1	488	1	MCF2L2	3	182923668	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	160340	182923668	15098762	248	28724										
KLHL6	89857	broad.mit.edu	37	chr3	183225916	183225916	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acctctgggcactgcctgatGagaggatctgcttccaccgt	11	13	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:183225916G>A	uc003flr.2	-	3	898	c.840C>T	c.(838-840)CTC>CTT	p.L280L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Silent_p.L278L	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	280										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			ACTGCCTGATGAGAGGATCTG	0.527													0	0	0	0.005443	0	28	66										A	183225916	G	A	183225916	2	1	96	1	0	0	0	0	0	0	0	1	8393	1277	45	1		1	KLHL6	3	183225916	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	302248	183225916	14796514	249	28725										
ECE2	9718	broad.mit.edu	37	chr3	183967544	183967544	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggagcggaactgcgggtaccGcgaagtcgagtactgggatc	17	9	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:183967544G>T	uc003fni.3	+	1	100	c.62G>T	c.(61-63)CGC>CTC	p.R21L	ALG3_uc003fne.2_5'Flank|ALG3_uc011brc.1_5'Flank|ALG3_uc011brd.1_5'Flank|ALG3_uc011bre.1_5'Flank|ALG3_uc003fnf.1_5'Flank|ALG3_uc011brf.1_5'Flank|ECE2_uc003fnh.3_Missense_Mutation_p.R21L	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	21	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCGGGTACCGCGAAGTCGAG	0.667											OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00307968	0.00308	0.00364399	8	56										T	183967544	G	T	183967544	3	4	96	1	0	0	0	0	1	0	0	0	4890	1087	38	4	64	4	ECE2	3	183967544	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	741628	183967544	14054886	250	28726										
C3orf70	285382	broad.mit.edu	37	chr3	184870595	184870595	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaccccgctccgacgccggcGaggccgccgcactcatttcc	10	20	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:184870595G>C	uc003fpd.2	-	1	208	c.17C>G	c.(16-18)TCG>TGG	p.S6W		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	6											0						CGACGCCGGCGAGGCCGCCGC	0.716													0	0	0	0.000248	0	3	14										C	184870595	G	C	184870595	3	2	96	1	0	0	0	0	1	0	0	0	2242	1059	37	1	743	1	C3orf70	3	184870595	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	903051	184870595	13151835	251	28727										
DGKG	1608	broad.mit.edu	37	chr3	185879433	185879433	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggttctccatccacttgcaTtggcagcagcttgtttgtcc	10	12	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:185879433T>C	uc003fqa.2	-	24	2773	c.2236A>G	c.(2236-2238)ATG>GTG	p.M746V	DGKG_uc003fqb.2_Missense_Mutation_p.M707V|DGKG_uc003fqc.2_Missense_Mutation_p.M721V|DGKG_uc011brx.1_Missense_Mutation_p.M687V	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	746					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCCACTTGCATTGGCAGCAGC	0.483													0	0	0	0.006214	0	8	65										C	185879433	T	C	185879433	3	2	96	1	0	0	0	0	1	0	0	0	4469	1493	52	5	147	5	DGKG	3	185879433	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	1008838	185879433	12142997	252	28728										
ACAP2	23527	broad.mit.edu	37	chr3	195102746	195102746	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcattgcaatacaaagtttCacaagctgaaaaagaaaaaa	5	6	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:195102746C>A	uc003fun.3	-	3	358	c.117G>T	c.(115-117)GTG>GTT	p.V39V	ACAP2_uc003fuo.2_Silent_p.V39V	NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	39	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TACAAAGTTTCACAAGCTGAA	0.338													1	0	1.15088e-07	0.004007	1.39853e-07	13	24										A	195102746	C	A	195102746	2	1	96	1	0	0	0	0	0	0	0	1	119	813	29	3		3	ACAP2	3	195102746	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9223313	195102746	2919684	253	28729										
IQCG	84223	broad.mit.edu	37	chr3	197652962	197652962	+	Missense_Mutation	SNP	C	C	T													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagtgatattatctgttttCttcctttttcctccctagaa							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:197652962C>T	uc003fyo.2	-	6	805	c.659G>A	c.(658-660)AGA>AAA	p.R220K	IQCG_uc003fyn.2_Missense_Mutation_p.R122K|IQCG_uc003fyp.2_Missense_Mutation_p.R220K|IQCG_uc003fyq.3_Missense_Mutation_p.R220K	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	220											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TATCTGTTTTCTTCCTTTTTC	0.244													0	0	0	0.002299	0	24	43										T	197652962	C	T	197652962	3	4	96	1	0	0	0	0	1	0	0	0	7810	913	32	1	696	1	IQCG	3	197652962	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2550216	197652962	369468	254	28730	144	2								
IQCG	84223	broad.mit.edu	37	chr3	197652965	197652965	+	Missense_Mutation	SNP	C	C	T													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgatattatctgttttcttCctttttcctccctagaagat							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr3:197652965C>T	uc003fyo.2	-	6	802	c.656G>A	c.(655-657)GGA>GAA	p.G219E	IQCG_uc003fyn.2_Missense_Mutation_p.G121E|IQCG_uc003fyp.2_Missense_Mutation_p.G219E|IQCG_uc003fyq.3_Missense_Mutation_p.G219E	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	219											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		CTGTTTTCTTCCTTTTTCCTC	0.234													0	0	0	0.008871	0	21	41										T	197652965	C	T	197652965	3	4	96	1	0	0	0	0	1	0	0	0	7810	855	30	1	699	1	IQCG	3	197652965	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3	197652965	369465	255	28731	144	2								
FGFR3	2261	broad.mit.edu	37	chr4	1806119	1806119	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgcaggcatcctcagctacGgggtgggcttcttcctgttc	12	12	2	0	rs28931614		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:1806119G>A	uc003gdr.3	+	9	1394	c.1138G>A	c.(1138-1140)GGG>AGG	p.G380R	FGFR3_uc003gdu.2_Missense_Mutation_p.G382R|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.G380R	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	380	Helical; (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.G380R(15)|p.G380E(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCTCAGCTACGGGGTGGGCTT	0.672		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00361	0	167	154										A	1806119	G	A	1806119	3	1	96	1	0	0	0	0	1	0	0	0	5867	1116	39	2	1323	2	FGFR3	4	1806119	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		1806119	189348157	256	28732										
ADRA2C	152	broad.mit.edu	37	chr4	3769370	3769370	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggggcccggtggccgcctgtCgcgcgccagctcgcgctccg	17	18	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:3769370C>G	uc003ghm.2	+	1	1075	c.1037C>G	c.(1036-1038)TCG>TGG	p.S346W	ADRA2C_uc010icx.2_Intron	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	346	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GGCCGCCTGTCGCGCGCCAGC	0.607													0	0	0	0.001168	0	5	2										G	3769370	C	G	3769370	3	3	96	1	0	0	0	0	1	0	0	0	339	893	31	1	1039	1	ADRA2C	4	3769370	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1963251	3769370	187384906	257	28733										
CLNK	116449	broad.mit.edu	37	chr4	10566338	10566338	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccaggtcggctgtccaatgGagatagaggtcctggtgtct	14	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:10566338G>A	uc003gmo.3	-	7	493	c.356C>T	c.(355-357)TCC>TTC	p.S119F	CLNK_uc003gmp.2_Missense_Mutation_p.S77F	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	119					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						CTGTCCAATGGAGATAGAGGT	0.453													0	0	0	0.002852	0	37	42										A	10566338	G	A	10566338	3	1	96	1	0	0	0	0	1	0	0	0	3547	1174	41	1	982	1	CLNK	4	10566338	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6796968	10566338	180587938	258	28734										
PGM2	55276	broad.mit.edu	37	chr4	37839181	37839181	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttgctgcaaccacatttatCagtcaggggattcctgtgta	9	10	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:37839181C>T	uc011byb.1	+	4	460	c.387C>T	c.(385-387)ATC>ATT	p.I129I	PGM2_uc011bya.1_5'UTR|PGM2_uc011byc.1_Intron	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	129					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						CCACATTTATCAGTCAGGGGA	0.458													0	0	0	0.00361	0	49	128										T	37839181	C	T	37839181	2	4	96	1	0	0	0	0	0	0	0	1	11798	816	29	1		1	PGM2	4	37839181	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	27272843	37839181	153315095	259	28735										
SGCB	6443	broad.mit.edu	37	chr4	52894145	52894145	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatactcaccgcctttaactCcatattaccacccatgtgaa	3	14	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:52894145C>G	uc003gzj.2	-	5	802	c.742G>C	c.(742-744)GAG>CAG	p.E248Q	SGCB_uc011bzp.1_Missense_Mutation_p.E178Q	NM_000232	NP_000223	Q16585	SGCB_HUMAN	sarcoglycan, beta	248	Extracellular (Potential).|Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma					0			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GCCTTTAACTCCATATTACCA	0.289													0	0	0	0.007413	0	18	90										G	52894145	C	G	52894145	3	3	96	1	0	0	0	0	1	0	0	0	14200	864	30	1	222	1	SGCB	4	52894145	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	15054964	52894145	138260131	260	28736										
SRD5A3	79644	broad.mit.edu	37	chr4	56236183	56236183	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggccctgtctgcctttctCagccaccaattctacaaaag	6	15	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:56236183C>T	uc003hau.2	+	5	977	c.882C>T	c.(880-882)CTC>CTT	p.L294L	uc003hav.1_Intron|uc003haw.1_Intron	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	294	Cytoplasmic (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			CTGCCTTTCTCAGCCACCAAT	0.423													0	0	0	0.004656	0	26	86										T	56236183	C	T	56236183	2	4	96	1	0	0	0	0	0	0	0	1	15139	813	29	1		1	SRD5A3	4	56236183	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3342038	56236183	134918093	261	28737										
LPHN3	23284	broad.mit.edu	37	chr4	62542622	62542622	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtccaggaacctataaataCcttgaagtgcagtatgaatg	9	7	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:62542622C>T	uc010ihh.2	+	3	521	c.348C>T	c.(346-348)TAC>TAT	p.Y116Y	LPHN3_uc003hcq.3_Silent_p.Y116Y|LPHN3_uc010ihg.1_Silent_p.Y184Y	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	116	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCTATAAATACCTTGAAGTGC	0.398													0	0	0	0.001368	0	12	274										T	62542622	C	T	62542622	2	4	96	1	0	0	0	0	0	0	0	1	8917	518	18	2		2	LPHN3	4	62542622	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6306439	62542622	128611654	262	28738										
SMR3A	26952	broad.mit.edu	37	chr4	71232530	71232530	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccaccctatggtccagggaGaatcccaccatcccctcctc	6	19	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:71232530G>A	uc003hfg.1	+	3	305	c.224G>A	c.(223-225)AGA>AAA	p.R75K	SMR3B_uc011cas.1_Intron	NM_012390	NP_036522	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3	75	Pro-rich.					extracellular region					0		all_hematologic(202;0.196)				GGTCCAGGGAGAATCCCACCA	0.537													0	0	0	0.007291	0	27	173										A	71232530	G	A	71232530	3	1	96	1	0	0	0	0	1	0	0	0	14811	942	33	1	230	1	SMR3A	4	71232530	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8689908	71232530	119921746	263	28739										
SHROOM3	57619	broad.mit.edu	37	chr4	77357273	77357273	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctaacacggccaccaaggGaaggtacatttatctggagg	11	10	2	0	rs142735873		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:77357273G>A	uc011cbx.1	+	1	1021	c.68G>A	c.(67-69)GGA>GAA	p.G23E		NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	23					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCCACCAAGGGAAGGTACATT	0.473													0	0	0	0.00361	0	54	143										A	77357273	G	A	77357273	3	1	96	1	0	0	0	0	1	0	0	0	14295	1174	41	1	70	1	SHROOM3	4	77357273	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6124743	77357273	113797003	264	28740										
SHROOM3	57619	broad.mit.edu	37	chr4	77651964	77651964	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtgtctccccaggcgcagtGagcctgcaggccgacctcac	12	16	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:77651964G>A	uc011cbx.1	+	4	1416	c.463G>A	c.(463-465)GAG>AAG	p.E155K	SHROOM3_uc011cbz.1_5'UTR|SHROOM3_uc003hkf.1_Missense_Mutation_p.E30K	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	155					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			CAGGCGCAGTGAGCCTGCAGG	0.562													0	0	0	0.00361	0	48	87										A	77651964	G	A	77651964	3	1	96	1	0	0	0	0	1	0	0	0	14295	1291	45	1	477	1	SHROOM3	4	77651964	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	294691	77651964	113502312	265	28741										
SPARCL1	8404	broad.mit.edu	37	chr4	88401595	88401595	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acatacatgtggtagtttttCttaaagtcccttaagagaag	8	6	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:88401595C>G	uc010ikm.2	-	10	2318	c.1746G>C	c.(1744-1746)AAG>AAC	p.K582N	SPARCL1_uc011cdc.1_Missense_Mutation_p.K457N|SPARCL1_uc003hqs.3_Missense_Mutation_p.K582N|SPARCL1_uc011cdd.1_Missense_Mutation_p.K457N	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	582					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		GGTAGTTTTTCTTAAAGTCCC	0.423													0	0	0	0.001786	0	27	81										G	88401595	C	G	88401595	3	3	96	1	0	0	0	0	1	0	0	0	14995	912	32	1	260	1	SPARCL1	4	88401595	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10749631	88401595	102752681	266	28742										
PKD2	5311	broad.mit.edu	37	chr4	88996667	88996667	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aacagatggaacggctagtaCgtgaagagttggaacgctgg	15	6	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:88996667C>A	uc003hre.2	+	15	2794	c.2728C>A	c.(2728-2730)CGT>AGT	p.R910S	PKD2_uc011cdf.1_Missense_Mutation_p.R328S|PKD2_uc011cdg.1_Missense_Mutation_p.R236S|PKD2_uc011cdh.1_Missense_Mutation_p.R133S	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	910	Potential.|C-terminal coiled coil domain.|Cytoplasmic (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ACGGCTAGTACGTGAAGAGTT	0.507													1	0	2.61193e-14	0.001786	3.27344e-14	33	256										A	88996667	C	A	88996667	3	1	96	1	0	0	0	0	1	0	0	0	11966	536	19	4	2786	4	PKD2	4	88996667	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	595072	88996667	102157609	267	28743										
FAM13A	10144	broad.mit.edu	37	chr4	89709016	89709016	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttctgagtcctctgaactttGacctccagagttattaacat	6	10	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:89709016G>T	uc003hse.1	-	10	1367	c.1159C>A	c.(1159-1161)CAA>AAA	p.Q387K	FAM13A_uc003hsb.1_Missense_Mutation_p.Q61K|FAM13A_uc003hsd.1_Missense_Mutation_p.Q61K|FAM13A_uc003hsc.1_Missense_Mutation_p.Q47K|FAM13A_uc011cdq.1_Missense_Mutation_p.Q33K|FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsg.1_5'UTR|FAM13A_uc003hsh.1_Missense_Mutation_p.Q201K|FAM13A_uc010ikr.1_5'UTR	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	387					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TCTGAACTTTGACCTCCAGAG	0.463													1	0	1.05317e-09	0.00245	1.29843e-09	13	94										T	89709016	G	T	89709016	3	4	96	1	0	0	0	0	1	0	0	0	5452	1299	45	3	1972	3	FAM13A	4	89709016	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	712349	89709016	101445260	268	28744										
TIGD2	166815	broad.mit.edu	37	chr4	90034378	90034378	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcttgatagagttatgataGagtggtttaaccaacagaaa	10	4	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:90034378G>C	uc003hsk.2	+	1	411	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	85	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		AGTTATGATAGAGTGGTTTAA	0.393													0	0	0	0.006122	0	15	65										C	90034378	G	C	90034378	3	2	96	1	0	0	0	0	1	0	0	0	15893	943	33	1	255	1	TIGD2	4	90034378	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	325362	90034378	101119898	269	28745										
MTTP	4547	broad.mit.edu	37	chr4	100503108	100503108	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatgaccggctgtacaagctCacgtactccactgaagttct	8	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:100503108C>G	uc003hvc.3	+	3	364	c.108C>G	c.(106-108)CTC>CTG	p.L36L	MTTP_uc011cej.1_Silent_p.L63L|MTTP_uc003hvb.2_Silent_p.L36L	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	36	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TGTACAAGCTCACGTACTCCA	0.458													0	0	0	0.00499	0	17	79										G	100503108	C	G	100503108	2	3	96	1	0	0	0	0	0	0	0	1	9964	813	29	1		1	MTTP	4	100503108	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10468730	100503108	90651168	270	28746										
CENPE	1062	broad.mit.edu	37	chr4	104079969	104079969	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctattttctaattgttccttCagctgttccatctcatttag	4	10	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:104079969C>T	uc003hxb.1	-	23	2766	c.2676G>A	c.(2674-2676)CTG>CTA	p.L892L	CENPE_uc003hxc.1_Silent_p.L867L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	892	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ATTGTTCCTTCAGCTGTTCCA	0.348													0	0	0	0.001882	0	22	49										T	104079969	C	T	104079969	2	4	96	1	0	0	0	0	0	0	0	1	3230	813	29	1		1	CENPE	4	104079969	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3576861	104079969	87074307	271	28747										
KIAA1109	84162	broad.mit.edu	37	chr4	123270446	123270446	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagtagttggagggaccataGatgtcaatgctttggagatg	15	4	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:123270446G>T	uc003ieh.2	+	76	13459	c.13414G>T	c.(13414-13416)GAT>TAT	p.D4472Y	KIAA1109_uc003iem.2_Missense_Mutation_p.D828Y	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4472					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGGGACCATAGATGTCAATGC	0.368													1	0	2.4624e-09	0.008871	3.02032e-09	19	27										T	123270446	G	T	123270446	3	4	96	1	0	0	0	0	1	0	0	0	8208	942	33	3	13716	3	KIAA1109	4	123270446	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	19190477	123270446	67883830	272	28748										
PGRMC2	10424	broad.mit.edu	37	chr4	129193566	129193566	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctccatttgtactgcattCaaatctgagagatcatcata	5	10	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:129193566C>G	uc003igg.2	-	2	530	c.525G>C	c.(523-525)TTG>TTC	p.L175F		NM_006320	NP_006311			progesterone receptor membrane component 2												0						GTACTGCATTCAAATCTGAGA	0.353													0	0	0	0.001984	0	5	39										G	129193566	C	G	129193566	3	3	96	1	0	0	0	0	1	0	0	0	11807	825	29	1	154	1	PGRMC2	4	129193566	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5923120	129193566	61960710	273	28749										
PGRMC2	10424	broad.mit.edu	37	chr4	129193594	129193594	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagatcatcatattcatctCtaagtgcatctttatctagg	6	8	6	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:129193594C>G	uc003igg.2	-	2	502	c.497G>C	c.(496-498)AGA>ACA	p.R166T		NM_006320	NP_006311			progesterone receptor membrane component 2												0						ATATTCATCTCTAAGTGCATC	0.373													0	0	0	0.001168	0	5	33										G	129193594	C	G	129193594	3	3	96	1	0	0	0	0	1	0	0	0	11807	913	32	1	182	1	PGRMC2	4	129193594	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	28	129193594	61960682	274	28750										
MAML3	55534	broad.mit.edu	37	chr4	140641044	140641044	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggactgttcccataaggctCtgcagccttggaggggcttg	14	10	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:140641044C>G	uc003ihz.1	-	7	3587	c.2835G>C	c.(2833-2835)CAG>CAC	p.Q945H	MGST2_uc010ioi.1_Intron|MAML3_uc011chd.1_Missense_Mutation_p.Q413H	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	946	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					CCATAAGGCTCTGCAGCCTTG	0.567													0	0	0	0.002522	0	42	96										G	140641044	C	G	140641044	3	3	96	1	0	0	0	0	1	0	0	0	9207	912	32	1	570	1	MAML3	4	140641044	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	11447450	140641044	50513232	275	28751										
TBC1D9	23158	broad.mit.edu	37	chr4	141555214	141555214	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttccacatgcccaaggaaaGagaagagcaaacattccctt	8	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:141555214G>C	uc010ioj.2	-	16	2906	c.2634C>G	c.(2632-2634)CTC>CTG	p.L878L		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	878						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				CCCAAGGAAAGAGAAGAGCAA	0.522													0	0	0	0.00308	0	8	32										C	141555214	G	C	141555214	2	2	96	1	0	0	0	0	0	0	0	1	15624	929	33	1		1	TBC1D9	4	141555214	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	914170	141555214	49599062	276	28752										
LRBA	987	broad.mit.edu	37	chr4	151511949	151511949	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatctcgttttctgagttctGatttcctaaagcctgactcc	7	11	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:151511949G>C	uc010ipj.2	-	40	6616	c.6142C>G	c.(6142-6144)CAG>GAG	p.Q2048E	LRBA_uc003ilt.3_Missense_Mutation_p.Q696E|LRBA_uc003ilu.3_Missense_Mutation_p.Q2037E	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2048						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TCTGAGTTCTGATTTCCTAAA	0.428													0	0	0	0.00874	0	40	45										C	151511949	G	C	151511949	3	2	96	1	0	0	0	0	1	0	0	0	8931	1299	45	1	2525	1	LRBA	4	151511949	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9956735	151511949	39642327	277	28753										
GUCY1A3	2982	broad.mit.edu	37	chr4	156632044	156632044	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcctccctgcttccataatGattgcagcgagtttgtgaat	9	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:156632044G>C	uc003iov.2	+	7	1263	c.727G>C	c.(727-729)GAT>CAT	p.D243H	GUCY1A3_uc003iou.2_Missense_Mutation_p.D243H|GUCY1A3_uc010iqc.2_Missense_Mutation_p.D243H|GUCY1A3_uc003iow.2_Missense_Mutation_p.D243H|GUCY1A3_uc010iqd.2_Missense_Mutation_p.D242H|GUCY1A3_uc003iox.2_Missense_Mutation_p.D243H|GUCY1A3_uc003ioz.2_Missense_Mutation_p.D8H|GUCY1A3_uc003ioy.2_Missense_Mutation_p.D243H|GUCY1A3_uc010iqe.2_Missense_Mutation_p.D8H|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.D243H	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	243					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTTCCATAATGATTGCAGCGA	0.502													0	0	0	0.002836	0	32	103										C	156632044	G	C	156632044	3	2	96	1	0	0	0	0	1	0	0	0	6894	1290	45	1	741	1	GUCY1A3	4	156632044	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5120095	156632044	34522232	278	28754										
RAPGEF2	9693	broad.mit.edu	37	chr4	160244633	160244633	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggactcctggtcagtgattcTcaatggatctgtggaagtga	13	7	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:160244633T>G	uc003iqg.3	+	5	840	c.530T>G	c.(529-531)CTC>CGC	p.L177R		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	177	cNMP.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TCAGTGATTCTCAATGGATCT	0.398													0	0	0	0.00333	0	22	46										G	160244633	T	G	160244633	3	3	96	1	0	0	0	0	1	0	0	0	13044	1551	54	5	548	5	RAPGEF2	4	160244633	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	3612589	160244633	30909643	279	28755										
SC4MOL	6307	broad.mit.edu	37	chr4	166254535	166254535	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgaaaaatggcaacaaatGaaagtgtcagcatctttagt	8	5	2	2	rs146748626	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:166254535G>A	uc003ire.2	+	2	143	c.13G>A	c.(13-15)GAA>AAA	p.E5K	SC4MOL_uc010irb.2_Missense_Mutation_p.E5K|SC4MOL_uc003irf.2_Intron	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	5					cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	GGCAACAAATGAAAGTGTCAG	0.323													0	0	0	0.00333	0	21	56										A	166254535	G	A	166254535	3	1	96	1	0	0	0	0	1	0	0	0	13865	1291	45	1	15	1	SC4MOL	4	166254535	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6009902	166254535	24899741	280	28756										
SC4MOL	6307	broad.mit.edu	37	chr4	166258996	166258996	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttcaaagttcttctctttaAtcacttctgtatccagctgc	4	11	5	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:166258996A>T	uc003ire.2	+	3	441	c.311A>T	c.(310-312)AAT>ATT	p.N104I	SC4MOL_uc010irb.2_Missense_Mutation_p.N104I|SC4MOL_uc003irf.2_5'UTR	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	104	Helical; (Potential).				cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	CTTCTCTTTAATCACTTCTGT	0.353													0	0	0	0.001523	0	21	48										T	166258996	A	T	166258996	3	4	96	1	0	0	0	0	1	0	0	0	13865	101	4	5	317	5	SC4MOL	4	166258996	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	4461	166258996	24895280	281	28757										
SNX25	83891	broad.mit.edu	37	chr4	186244769	186244769	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggaaaaatcactttacaaaGaaattcagcagtgtcttgta	7	6	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:186244769G>C	uc003ixh.2	+	9	1261	c.1072G>C	c.(1072-1074)GAA>CAA	p.E358Q	SNX25_uc010ish.2_Missense_Mutation_p.E129Q|SNX25_uc003ixi.2_5'UTR	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	358	RGS.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		ACTTTACAAAGAAATTCAGCA	0.328													0	0	0	0.008871	0	20	31										C	186244769	G	C	186244769	3	2	96	1	0	0	0	0	1	0	0	0	14896	943	33	1	1102	1	SNX25	4	186244769	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	19985773	186244769	4909507	282	28758										
CCDC110	256309	broad.mit.edu	37	chr4	186392204	186392204	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcttcccggtgctgcttttCtgtaacagaaccgtccgggg	11	13	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:186392204C>T	uc003ixu.3	-	2	87	c.11_splice	c.e2-1	p.E4_splice	CCDC110_uc003ixv.3_Splice_Site_p.E4_splice|CCDC110_uc011ckt.1_Splice_Site_p.E4_splice	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a							nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TGCTGCTTTTCTGTAACAGAA	0.458													0	0	0	0.002222	0	42	74										T	186392204	C	T	186392204	5	4	96	1	0	0	0	0	0	0	1	0	2747	927	32	1	2515	1	CCDC110	4	186392204	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	147435	186392204	4762072	283	28759										
KLKB1	3818	broad.mit.edu	37	chr4	187173013	187173013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgtaacactggggacaactCtggtgagtaacctcactttt	10	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187173013C>G	uc003iyy.2	+	10	1213	c.1142C>G	c.(1141-1143)TCT>TGT	p.S381C	KLKB1_uc011clc.1_Missense_Mutation_p.S179C|KLKB1_uc011cld.1_Missense_Mutation_p.S343C	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	381					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGGGACAACTCTGGTGAGTAA	0.423													0	0	0	0.001523	0	20	109										G	187173013	C	G	187173013	3	3	96	1	0	0	0	0	1	0	0	0	8412	913	32	1	1176	1	KLKB1	4	187173013	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	780809	187173013	3981263	284	28760										
FAT1	2195	broad.mit.edu	37	chr4	187510105	187510115	+	Frame_Shift_Del	DEL	CAGGCATGTCT	CAGGCATGTCT	-													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaacccaagctacccgcggCaggcatgtctctaggagggt							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187510105_187510115delCAGGCATGTCT	uc003izf.2	-	27	13586_13596	c.13398_13408delAGACATGCCTG	c.(13396-13410)AGAGACATGCCTGCCfs	p.R4466fs	FAT1_uc010isn.2_Frame_Shift_Del_p.R113fs|FAT1_uc003ize.2_Frame_Shift_Del_p.R357fs	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4466_4470	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CTACCCGCGGCAGGCATGTCTCTAGGAGGGT	0.502										HNSCC(5;0.00058)								16	295	---	---								-	187510115	CAGGCATGTCT	-	187510105	7	5	96	1	0	1	0	1	0	0	0	0	5689	710	25	0	362	0	FAT1	4	187510105	Frame_Shift_Del	DEL	CAGGCATGTCT	TCGA-G2-A2EO-01A-11D-A17V-08	337092	187510105	3644171	285	28761										
FAT1	2195	broad.mit.edu	37	chr4	187521209	187521209	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaagggagctcctgcccattCaaataaatggagtccataca	8	10	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187521209C>G	uc003izf.2	-	22	12134	c.11946G>C	c.(11944-11946)TTG>TTC	p.L3982F	FAT1_uc003ize.2_5'Flank	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3982	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCTGCCCATTCAAATAAATGG	0.498										HNSCC(5;0.00058)			0	0	0	0.00361	0	60	114										G	187521209	C	G	187521209	3	3	96	1	0	0	0	0	1	0	0	0	5689	825	29	1	1844	1	FAT1	4	187521209	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	11104	187521209	3633067	286	28762										
FAT1	2195	broad.mit.edu	37	chr4	187531098	187531098	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtgaaggcgtgcctccatCagtggcctctactgttaggt	12	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr4:187531098C>T	uc003izf.2	-	15	10113	c.9925G>A	c.(9925-9927)GAT>AAT	p.D3309N		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3309	Extracellular (Potential).|Cadherin 30.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGCCTCCATCAGTGGCCTCT	0.443										HNSCC(5;0.00058)			0	0	0	0.008291	0	10	43										T	187531098	C	T	187531098	3	4	96	1	0	0	0	0	1	0	0	0	5689	826	29	1	3893	1	FAT1	4	187531098	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9889	187531098	3623178	287	28763										
PLEKHG4B	153478	broad.mit.edu	37	chr5	174135	174135	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggacacctacattctccaaGcaagctcggcagaggtcaag	10	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:174135G>C	uc003jak.2	+	16	3306	c.3256G>C	c.(3256-3258)GCA>CCA	p.A1086P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1086	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CATTCTCCAAGCAAGCTCGGC	0.582													0	0	0	0.004482	0	9	11										C	174135	G	C	174135	3	2	96	1	0	0	0	0	1	0	0	0	12072	971	34	4	3318	4	PLEKHG4B	5	174135	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		174135	180741125	288	28764										
PLEKHG4B	153478	broad.mit.edu	37	chr5	174155	174155	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaagctcggcagaggtcaaGagtgcatggaccgatgtcat	14	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:174155G>C	uc003jak.2	+	16	3326	c.3276G>C	c.(3274-3276)AAG>AAC	p.K1092N		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	1092	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		CAGAGGTCAAGAGTGCATGGA	0.592													0	0	0	0.001168	0	6	7										C	174155	G	C	174155	3	2	96	1	0	0	0	0	1	0	0	0	12072	933	33	1	3338	1	PLEKHG4B	5	174155	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	20	174155	180741105	289	28765										
SLC6A3	6531	broad.mit.edu	37	chr5	1414876	1414876	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccaggaaggagaagacgacGaagccggaggagaagctcgt	16	9	0	3	rs28363072		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:1414876G>C	uc003jck.2	-	8	1207	c.1086C>G	c.(1084-1086)TTC>TTG	p.F362L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	362	Helical; Name=7; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGAAGACGACGAAGCCGGAGG	0.617													0	0	0	0.00499	0	14	62										C	1414876	G	C	1414876	3	2	96	1	0	0	0	0	1	0	0	0	14685	1049	37	1	808	1	SLC6A3	5	1414876	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1240721	1414876	179500384	290	28766										
KIAA0947	23379	broad.mit.edu	37	chr5	5464123	5464123	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taagaatcgatcaaagatttCaaacaaagatcagtcaaaca	5	7	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:5464123C>T	uc003jdm.3	+	13	4898	c.4676C>T	c.(4675-4677)TCA>TTA	p.S1559L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1559										ovary(1)|central_nervous_system(1)	2						TCAAAGATTTCAAACAAAGAT	0.373													0	0	0	0.00308	0	8	55										T	5464123	C	T	5464123	3	4	96	1	0	0	0	0	1	0	0	0	8202	838	29	1	4726	1	KIAA0947	5	5464123	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4049247	5464123	175451137	291	28767										
NSUN2	54888	broad.mit.edu	37	chr5	6620355	6620355	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gctgctcagcctcttggcttGatggacgagcaggtagcagc	14	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:6620355G>C	uc003jdu.2	-	7	744	c.679C>G	c.(679-681)CAA>GAA	p.Q227E	NSUN2_uc003jdt.2_Translation_Start_Site|NSUN2_uc011cmk.1_Missense_Mutation_p.Q192E|NSUN2_uc003jdv.2_Translation_Start_Site	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	227						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						CTCTTGGCTTGATGGACGAGC	0.522													0	0	0	0.00623	0	37	114										C	6620355	G	C	6620355	3	2	96	1	0	0	0	0	1	0	0	0	10678	1299	45	1	1676	1	NSUN2	5	6620355	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1156232	6620355	174294905	292	28768										
ADCY2	108	broad.mit.edu	37	chr5	7789838	7789838	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atagagaccatggagaacctGaaccgcgtgctgctggagaa	13	9	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:7789838G>A	uc003jdz.1	+	20	2620	c.2553G>A	c.(2551-2553)CTG>CTA	p.L851L	ADCY2_uc011cmo.1_Silent_p.L671L|ADCY2_uc010itm.1_Silent_p.L47L	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	851	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TGGAGAACCTGAACCGCGTGC	0.527													0	0	0	0.002096	0	33	83										A	7789838	G	A	7789838	2	1	96	1	0	0	0	0	0	0	0	1	294	1277	45	1		1	ADCY2	5	7789838	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1169483	7789838	173125422	293	28769										
FASTKD3	79072	broad.mit.edu	37	chr5	7861360	7861360	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaaaacctttttggaccatCaatacacagtgctatcctga	6	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:7861360C>G	uc003jeb.2	-	6	1923	c.1786G>C	c.(1786-1788)GAT>CAT	p.D596H	FASTKD3_uc011cmp.1_Missense_Mutation_p.D298H|FASTKD3_uc003jec.2_RNA	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	596	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TTTGGACCATCAATACACAGT	0.279													0	0	0	0.00278	0	22	87										G	7861360	C	G	7861360	3	3	96	1	0	0	0	0	1	0	0	0	5687	826	29	1	210	1	FASTKD3	5	7861360	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	71522	7861360	173053900	294	28770										
DNAH5	1767	broad.mit.edu	37	chr5	13862845	13862845	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctctctctttcaccgcactGatacagatgtcctatcaaaa	4	13	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:13862845G>A	uc003jfd.2	-	29	4650	c.4608C>T	c.(4606-4608)ATC>ATT	p.I1536I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1536	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCACCGCACTGATACAGATGT	0.413									Kartagener_syndrome				0	0	0	0.007291	0	26	96										A	13862845	G	A	13862845	2	1	96	1	0	0	0	0	0	0	0	1	4604	1280	45	1		1	DNAH5	5	13862845	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6001485	13862845	167052415	295	28771										
CDH10	1008	broad.mit.edu	37	chr5	24505321	24505321	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttcctgaatgaatgttaaaGattctgtcaaggtcagtatg	9	5	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:24505321G>C	uc003jgr.1	-	8	1625	c.1293C>G	c.(1291-1293)ATC>ATG	p.I431M	CDH10_uc011cnu.1_Intron	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	431	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GAATGTTAAAGATTCTGTCAA	0.363										HNSCC(23;0.051)			0	0	0	0.006214	0	10	34										C	24505321	G	C	24505321	3	2	96	1	0	0	0	0	1	0	0	0	3096	932	33	1	1093	1	CDH10	5	24505321	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10642476	24505321	156409939	296	28772										
PDZD2	23037	broad.mit.edu	37	chr5	32087406	32087406	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccaggtctccagtcaggctCccccatgagggcagcccctc	11	18	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:32087406C>T	uc003jhl.2	+	20	4240	c.3852C>T	c.(3850-3852)CTC>CTT	p.L1284L	PDZD2_uc003jhm.2_Silent_p.L1284L	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1284					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CAGTCAGGCTCCCCCATGAGG	0.622													0	0	0	0.004878	0	34	100										T	32087406	C	T	32087406	2	4	96	1	0	0	0	0	0	0	0	1	11701	842	30	1		1	PDZD2	5	32087406	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7582085	32087406	148827854	297	28773										
NIPBL	25836	broad.mit.edu	37	chr5	37064931	37064931	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctaacgagtgctaataagctGactaataaagttgttcagac	8	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:37064931G>A	uc003jkl.3	+	47	8851	c.8352G>A	c.(8350-8352)CTG>CTA	p.L2784L	NIPBL_uc003jkk.3_3'UTR|NIPBL_uc003jkn.2_3'UTR	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2784					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTAATAAGCTGACTAATAAAG	0.408													0	0	0	0.002299	0	23	61										A	37064931	G	A	37064931	2	1	96	1	0	0	0	0	0	0	0	1	10428	1277	45	1		1	NIPBL	5	37064931	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4977525	37064931	143850329	298	28774										
ITGA2	3673	broad.mit.edu	37	chr5	52371064	52371064	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctatagtgaaagccaagaaGaaaacaaggctgataatttg	9	5	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:52371064G>A	uc003joy.2	+	23	2898	c.2755G>A	c.(2755-2757)GAA>AAA	p.E919K	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.E843K|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	919	Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AAGCCAAGAAGAAAACAAGGC	0.348													0	0	0	0.003163	0	15	45										A	52371064	G	A	52371064	3	1	96	1	0	0	0	0	1	0	0	0	7875	943	33	1	2845	1	ITGA2	5	52371064	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	15306133	52371064	128544196	299	28775										
GZMA	3001	broad.mit.edu	37	chr5	54398580	54398580	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctcctgctaattcctgaaGgtaagactgattcttctcat	6	11	3	3	rs142297007	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54398580G>C	uc003jpm.2	+	1	107	c.70G>C	c.(70-72)GAT>CAT	p.D24H		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	24					cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				AATTCCTGAAGGTAAGACTGA	0.408													0	0	0	0.001523	0	21	81										C	54398580	G	C	54398580	3	2	96	1	0	0	0	0	1	0	0	0	6915	1014	35	4	72	4	GZMA	5	54398580	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2027516	54398580	126516680	300	28776										
DHX29	54505	broad.mit.edu	37	chr5	54567922	54567922	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatttaaacttacttattttCttttgttcttccagtatcaa	2	7	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54567922C>G	uc003jpx.2	-	18	2977	c.2857G>C	c.(2857-2859)GAA>CAA	p.E953Q	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	953	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TACTTATTTTCTTTTGTTCTT	0.318													0	0	0	0.002522	0	45	31										G	54567922	C	G	54567922	3	3	96	1	0	0	0	0	1	0	0	0	4503	922	32	1	1292	1	DHX29	5	54567922	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	169342	54567922	126347338	301	28777										
DHX29	54505	broad.mit.edu	37	chr5	54585110	54585110	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aattttacctttctcttcttCagtagcagctgcagattttt	5	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54585110C>T	uc003jpx.2	-	8	1174	c.1054G>A	c.(1054-1056)GAA>AAA	p.E352K	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	352							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTCTCTTCTTCAGTAGCAGCT	0.313													0	0	0	0.000978	0	11	86										T	54585110	C	T	54585110	3	4	96	1	0	0	0	0	1	0	0	0	4503	835	29	1	3135	1	DHX29	5	54585110	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	17188	54585110	126330150	302	28778										
SLC38A9	153129	broad.mit.edu	37	chr5	54922343	54922343	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacataaaaaactgaacaatCaggttagccacgcccaaaat	5	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:54922343C>G	uc003jqf.2	-	16	1866	c.1665G>C	c.(1663-1665)CTG>CTC	p.L555L	SLC38A9_uc003jqd.2_Silent_p.L492L|SLC38A9_uc010ivx.2_Silent_p.L492L|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.L426L	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	555	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				ACTGAACAATCAGGTTAGCCA	0.358													0	0	0	0.00361	0	85	90										G	54922343	C	G	54922343	2	3	96	1	0	0	0	0	0	0	0	1	14611	813	29	1		1	SLC38A9	5	54922343	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	337233	54922343	125992917	303	28779										
ERBB2IP	55914	broad.mit.edu	37	chr5	65349978	65349978	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcaggaacaaaggcaattttCaagtttgattcaaatcataa	6	6	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:65349978C>T	uc003juk.1	+	21	3140	c.2832C>T	c.(2830-2832)TTC>TTT	p.F944F	ERBB2IP_uc003jui.1_Silent_p.F944F|ERBB2IP_uc003juj.1_Silent_p.F944F|ERBB2IP_uc011cqx.1_Silent_p.F944F|ERBB2IP_uc011cqy.1_Silent_p.F944F|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Silent_p.F940F|ERBB2IP_uc003jul.1_Silent_p.F940F	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	944					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGGCAATTTTCAAGTTTGATT	0.403													0	0	0	0.008291	0	11	69										T	65349978	C	T	65349978	2	4	96	1	0	0	0	0	0	0	0	1	5207	825	29	1		1	ERBB2IP	5	65349978	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10427635	65349978	115565282	304	28780										
BDP1	55814	broad.mit.edu	37	chr5	70751838	70751838	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcctgccacggactctgcttCcaagcccgcggagcccacag	10	18	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:70751838C>T	uc003kbp.1	+	1	397	c.134C>T	c.(133-135)TCC>TTC	p.S45F	BDP1_uc003kbn.1_Missense_Mutation_p.S45F|BDP1_uc003kbo.2_Missense_Mutation_p.S45F	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	45	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GACTCTGCTTCCAAGCCCGCG	0.632													0	0	0	0.00245	0	12	34										T	70751838	C	T	70751838	3	4	96	1	0	0	0	0	1	0	0	0	1395	855	30	1	136	1	BDP1	5	70751838	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5401860	70751838	110163422	305	28781										
BDP1	55814	broad.mit.edu	37	chr5	70805391	70805391	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ataggaagaggaactggaagGagagaaatttcctcaaagga	13	4	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:70805391G>T	uc003kbp.1	+	17	2735	c.2472G>T	c.(2470-2472)AGG>AGT	p.R824S	BDP1_uc003kbn.1_Missense_Mutation_p.R824S|BDP1_uc003kbo.2_Missense_Mutation_p.R824S	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	824	9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.|1; approximate.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GAACTGGAAGGAGAGAAATTT	0.413													1	0	6.72482e-11	0.003163	8.35526e-11	14	106										T	70805391	G	T	70805391	3	4	96	1	0	0	0	0	1	0	0	0	1395	1165	41	3	2538	3	BDP1	5	70805391	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	53553	70805391	110109869	306	28782										
HEXB	3074	broad.mit.edu	37	chr5	73981280	73981280	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgccgctcttggtgaagatGaccccgaacctgctgcatct	10	14	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:73981280G>A	uc003kdf.3	+	1	312	c.195G>A	c.(193-195)ATG>ATA	p.M65I	HEXB_uc003kdd.2_Intron|HEXB_uc003kde.2_Missense_Mutation_p.M65I|HEXB_uc010izh.2_RNA	NM_000521	NP_000512	P07686	HEXB_HUMAN	hexosaminidase B preproprotein	65					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		TGGTGAAGATGACCCCGAACC	0.697													0	0	0	0.008291	0	10	20										A	73981280	G	A	73981280	3	1	96	1	0	0	0	0	1	0	0	0	7074	1290	45	1	197	1	HEXB	5	73981280	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3175889	73981280	106933980	307	28783										
SV2C	22987	broad.mit.edu	37	chr5	75621207	75621207	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agggcaacaggctttggcttCttaaatgcgctatgcaaggc	12	9	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:75621207C>G	uc003kei.1	+	13	2153	c.2019C>G	c.(2017-2019)TTC>TTG	p.F673L		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	673	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GCTTTGGCTTCTTAAATGCGC	0.463													0	0	0	0.00632	0	26	71										G	75621207	C	G	75621207	3	3	96	1	0	0	0	0	1	0	0	0	15416	912	32	1	2065	1	SV2C	5	75621207	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1639927	75621207	105294053	308	28784										
ZCCHC9	84240	broad.mit.edu	37	chr5	80604427	80604427	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catggaattgcagattgcccCgccgcccttgaaaatcaaga	9	12	1	3	rs149561750	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:80604427C>T	uc003khj.2	+	3	565	c.432C>T	c.(430-432)CCC>CCT	p.P144P	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Silent_p.P144P|ZCCHC9_uc003khi.2_Silent_p.P144P	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	144	CCHC-type 1.						nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		CAGATTGCCCCGCCGCCCTTG	0.473													0	0	0	0.001523	0	20	51										T	80604427	C	T	80604427	2	4	96	1	0	0	0	0	0	0	0	1	17592	639	23	2		2	ZCCHC9	5	80604427	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4983220	80604427	100310833	309	28785										
VCAN	1462	broad.mit.edu	37	chr5	82850806	82850806	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gattatcagtggataggcctCaatgacaagatgtttgagca	11	6	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:82850806C>T	uc003kii.3	+	12	10040	c.9684C>T	c.(9682-9684)CTC>CTT	p.L3228L	VCAN_uc003kij.3_Silent_p.L2241L|VCAN_uc010jau.2_Silent_p.L1474L|VCAN_uc003kik.3_Silent_p.L487L|VCAN_uc003kil.3_Silent_p.L1892L	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	3228	C-type lectin.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGATAGGCCTCAATGACAAGA	0.403													0	0	0	0.00333	0	23	62										T	82850806	C	T	82850806	2	4	96	1	0	0	0	0	0	0	0	1	17135	813	29	1		1	VCAN	5	82850806	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2246379	82850806	98064454	310	28786										
RASA1	5921	broad.mit.edu	37	chr5	86564633	86564633	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcaccaaactgcccacttCgttgcttgctgagactctcg	7	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:86564633C>T	uc003kiw.2	+	1	483	c.365C>T	c.(364-366)TCG>TTG	p.S122L	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_5'Flank|RASA1_uc011ctv.1_5'Flank|RASA1_uc011ctw.1_5'Flank|RASA1_uc010jaw.2_5'Flank|RASA1_uc011ctu.1_Missense_Mutation_p.S122L	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	122					cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CTGCCCACTTCGTTGCTTGCT	0.473													0	0	0	0.004482	0	6	27										T	86564633	C	T	86564633	3	4	96	1	0	0	0	0	1	0	0	0	13060	893	31	1	367	1	RASA1	5	86564633	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3713827	86564633	94350627	311	28787										
FBXL17	64839	broad.mit.edu	37	chr5	107521822	107521822	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgttacaatggttacctgtCatttatgatccagttcagac	7	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:107521822C>T	uc011cvc.1	-	6	2148	c.1741G>A	c.(1741-1743)GAC>AAC	p.D581N	FBXL17_uc003kon.3_Missense_Mutation_p.D183N	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	581											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		GGTTACCTGTCATTTATGATC	0.313													0	0	0	0.001984	0	6	45										T	107521822	C	T	107521822	3	4	96	1	0	0	0	0	1	0	0	0	5713	826	29	1	380	1	FBXL17	5	107521822	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	20957189	107521822	73393438	312	28788										
ZNF608	57507	broad.mit.edu	37	chr5	123983433	123983433	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtgtaaaccttatcggcctCagctttgatactggccatgc	9	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:123983433C>T	uc003ktq.1	-	4	2767	c.2644G>A	c.(2644-2646)GAG>AAG	p.E882K	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.E882K|ZNF608_uc003ktt.1_Missense_Mutation_p.E882K	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	882						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTATCGGCCTCAGCTTTGATA	0.527													0	0	0	0.00245	0	14	87										T	123983433	C	T	123983433	3	4	96	1	0	0	0	0	1	0	0	0	18031	835	29	1	1918	1	ZNF608	5	123983433	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	16461611	123983433	56931827	313	28789										
SLC12A2	6558	broad.mit.edu	37	chr5	127514329	127514330	+	Frame_Shift_Ins	INS	-	-	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagctagtacacagtttcagINSaaaaaacaaggaaagaatac							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:127514329_127514330insA	uc003kus.2	+	22	3212_3213	c.3048_3049insA	c.(3046-3051)CAGAAAfs	p.Q1016fs	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Frame_Shift_Ins_p.Q1000fs	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	1016_1017	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACAGTTTCAGAAAAAACAAGG	0.307																		8	77	---	---								A	127514330	-	A	127514329	7	5	96	1	0	1	1	0	0	0	0	0	14383	933	33	0	3134	0	SLC12A2	5	127514329	Frame_Shift_Ins	INS	-	TCGA-G2-A2EO-01A-11D-A17V-08	3530896	127514329	53400931	314	28790										
C5orf56	441108	broad.mit.edu	37	chr5	131796262	131796262	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctctcaaccagggaatcttCaaactcttcttctccactgg	5	14	7	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:131796262C>G	uc003kwy.1	+	4	228	c.97C>G	c.(97-99)CAA>GAA	p.Q33E	C5orf56_uc003kwz.1_Intron|C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron	NM_001013717	NP_001013739	Q8N8D9	CE056_HUMAN	hypothetical protein LOC441108	33											0						agggaatcttcaaactcttct	0.02													0	0	0	0.003755	0	33	254										G	131796262	C	G	131796262	3	3	96	1	0	0	0	0	1	0	0	0	2312	827	29	1	107	1	C5orf56	5	131796262	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4281933	131796262	49118998	315	28791										
SKP1	6500	broad.mit.edu	37	chr5	133502935	133502935	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcatcatccattcccaaatCtaagaaaaccagaagaaagt	4	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:133502935C>T	uc003kzc.3	-	3	277	c.98_splice	c.e3-1	p.D33_splice	SKP1_uc003kzd.3_Splice_Site_p.D33_splice|SKP1_uc010jdv.2_Splice_Site_p.D33_splice	NM_170679	NP_733779	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1 isoform b						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATTCCCAAATCTAAGAAAACC	0.299													0	0	0	0.000978	0	12	69										T	133502935	C	T	133502935	5	4	96	1	0	0	0	0	0	0	1	0	14361	927	32	1	437	1	SKP1	5	133502935	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1706673	133502935	47412325	316	28792										
HSPA9	3313	broad.mit.edu	37	chr5	137902369	137902369	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcagcagcttcccgtaccctCtgaagtgccatgttgtcttt	8	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:137902369C>G	uc003ldf.2	-	9	1026	c.918G>C	c.(916-918)CAG>CAC	p.Q306H	HSPA9_uc011cyw.1_Missense_Mutation_p.Q237H	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	306					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCCGTACCCTCTGAAGTGCCA	0.438													0	0	0	0.004656	0	22	185										G	137902369	C	G	137902369	3	3	96	1	0	0	0	0	1	0	0	0	7417	912	32	1	1157	1	HSPA9	5	137902369	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4399434	137902369	43012891	317	28793										
SLC35A4	113829	broad.mit.edu	37	chr5	139947635	139947635	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtggtcaacgccgtgctctCagcagtcctgctacggctgc	13	14	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:139947635C>T	uc003lgg.1	+	3	1609	c.881C>T	c.(880-882)TCA>TTA	p.S294L	SLC35A4_uc003lgh.1_Missense_Mutation_p.S294L	NM_080670	NP_542401	Q96G79	S35A4_HUMAN	solute carrier family 35, member A4	294	Leu-rich.|Helical; (Potential).					Golgi membrane|integral to membrane	sugar:hydrogen symporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTGCTCTCAGCAGTCCTG	0.592													0	0	0	0.007413	0	19	49										T	139947635	C	T	139947635	3	4	96	1	0	0	0	0	1	0	0	0	14573	838	29	1	883	1	SLC35A4	5	139947635	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2045266	139947635	40967625	318	28794										
PCDHA5	56143	broad.mit.edu	37	chr5	140202747	140202747	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agccccagtataccgtgttcGtgaaggagaacaacccgcca	10	13	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140202747G>A	uc003lhl.2	+	1	1387	c.1387G>A	c.(1387-1389)GTG>ATG	p.V463M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.V463M|PCDHA5_uc003lhj.1_Missense_Mutation_p.V463M	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	463	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACCGTGTTCGTGAAGGAGAA	0.662													0	0	0	0.00632	0	28	94										A	140202747	G	A	140202747	3	1	96	1	0	0	0	0	1	0	0	0	11527	1145	40	2	1389	2	PCDHA5	5	140202747	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	255112	140202747	40712513	319	28795										
PCDHA6	56142	broad.mit.edu	37	chr5	140209836	140209836	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acgctactgctgtacacagcGctgcggtgctcggcgccacc	12	16	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140209836G>A	uc003lho.2	+	1	2187	c.2160G>A	c.(2158-2160)GCG>GCA	p.A720A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.A720A	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	720	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACACAGCGCTGCGGTGCT	0.677													0	0	0	0.000978	0	12	79										A	140209836	G	A	140209836	2	1	96	1	0	0	0	0	0	0	0	1	11528	1074	38	2		2	PCDHA6	5	140209836	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7089	140209836	40705424	320	28796										
PCDHA8	56140	broad.mit.edu	37	chr5	140222611	140222611	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgccggcactgctggagcctCgggtgggtggcactggtggc	19	12	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140222611C>G	uc003lhs.2	+	1	1705	c.1705C>G	c.(1705-1707)CGG>GGG	p.R569G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R569G	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	569	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGAGCCTCGGGTGGGTGG	0.721													0	0	0	0.005524	0	36	76										G	140222611	C	G	140222611	3	3	96	1	0	0	0	0	1	0	0	0	11530	875	31	1	1707	1	PCDHA8	5	140222611	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	12775	140222611	40692649	321	28797										
PCDHA9	9752	broad.mit.edu	37	chr5	140228108	140228108	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actcaagtcgaggagatccaGagggtcagcctctactgctc	11	12	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140228108G>C	uc003lhu.2	+	1	752	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.E10Q	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	10					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGATCCAGAGGGTCAGCC	0.493													0	0	0	0.00361	0	50	113										C	140228108	G	C	140228108	3	2	96	1	0	0	0	0	1	0	0	0	11531	943	33	1	30	1	PCDHA9	5	140228108	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5497	140228108	40687152	322	28798										
PCDHA10	56139	broad.mit.edu	37	chr5	140236081	140236081	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatccagactgcttgactctCgatttccactagaaggcgca	8	12	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140236081C>G	uc003lhx.2	+	1	448	c.448C>G	c.(448-450)CGA>GGA	p.R150G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.R150G|PCDHA10_uc011dad.1_Missense_Mutation_p.R150G	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	150	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTGACTCTCGATTTCCACT	0.438													0	0	0	0.00361	0	66	130										G	140236081	C	G	140236081	3	3	96	1	0	0	0	0	1	0	0	0	11520	876	31	1	450	1	PCDHA10	5	140236081	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7973	140236081	40679179	323	28799										
PCDHB6	56130	broad.mit.edu	37	chr5	140530815	140530815	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacagatggtggaggcctatCaggaaaatgctctttagtcg	12	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140530815C>T	uc003lir.2	+	1	977	c.977C>T	c.(976-978)TCA>TTA	p.S326L	PCDHB6_uc011dah.1_Missense_Mutation_p.S190L	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	326	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGCCTATCAGGAAAATGC	0.468													0	0	0	0.004007	0	17	48										T	140530815	C	T	140530815	3	4	96	1	0	0	0	0	1	0	0	0	11546	838	29	1	979	1	PCDHB6	5	140530815	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	294734	140530815	40384445	324	28800										
PCDHB7	56129	broad.mit.edu	37	chr5	140554506	140554506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcgttggcctcggtgtcttCgctcttcctcctctcggtgc	12	15	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140554506C>T	uc003lit.2	+	1	2264	c.2090C>T	c.(2089-2091)TCG>TTG	p.S697L	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	697	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTGTCTTCGCTCTTCCTC	0.706													0	0	0	0.003755	0	35	375										T	140554506	C	T	140554506	3	4	96	1	0	0	0	0	1	0	0	0	11547	893	31	1	2092	1	PCDHB7	5	140554506	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	23691	140554506	40360754	325	28801										
PCDHB11	56125	broad.mit.edu	37	chr5	140580555	140580555	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agttgagaattactacacgtTggaaacagagagaccactgg	11	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140580555T>A	uc003liy.2	+	1	1208	c.1208T>A	c.(1207-1209)TTG>TAG	p.L403*	PCDHB11_uc011daj.1_Nonsense_Mutation_p.L38*	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	403	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACTACACGTTGGAAACAGAG	0.478													0	0	0	0.001882	0	20	114										A	140580555	T	A	140580555	4	1	96	1	0	0	0	0	0	1	0	0	11536	1821	63	5	1210	5	PCDHB11	5	140580555	Nonsense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	26049	140580555	40334705	326	28802										
PCDHB13	56123	broad.mit.edu	37	chr5	140596055	140596055	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaaagaaatacaaggaaattCtaccttccccaataactttg	5	9	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140596055C>G	uc003lja.1	+	1	2547	c.2360C>G	c.(2359-2361)TCT>TGT	p.S787C		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	787	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAGGAAATTCTACCTTCCCC	0.428													0	0	0	0.003163	0	14	76										G	140596055	C	G	140596055	3	3	96	1	0	0	0	0	1	0	0	0	11538	913	32	1	2362	1	PCDHB13	5	140596055	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	15500	140596055	40319205	327	28803										
PCDHGA3	56112	broad.mit.edu	37	chr5	140724723	140724723	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttatcgacgtgcatgaccgaGattctgggcagaatgggcag	14	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140724723G>C	uc003ljm.1	+	1	1123	c.1123G>C	c.(1123-1125)GAT>CAT	p.D375H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.D135H|PCDHGA3_uc011dap.1_Missense_Mutation_p.D375H	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	375	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATGACCGAGATTCTGGGCA	0.448													0	0	0	0.00333	0	23	99										C	140724723	G	C	140724723	3	2	96	1	0	0	0	0	1	0	0	0	11555	942	33	1	1125	1	PCDHGA3	5	140724723	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	128668	140724723	40190537	328	28804										
PCDHGB3	56102	broad.mit.edu	37	chr5	140750497	140750497	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagccctgatccgcacttctCtttgattcagaaggagaacc	8	13	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140750497C>G	uc003ljw.1	+	1	536	c.536C>G	c.(535-537)TCT>TGT	p.S179C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.S179C	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	179	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCACTTCTCTTTGATTCAG	0.542													0	0	0	0.00361	0	92	170										G	140750497	C	G	140750497	3	3	96	1	0	0	0	0	1	0	0	0	11564	913	32	1	538	1	PCDHGB3	5	140750497	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	25774	140750497	40164763	329	28805										
PCDHGB4	8641	broad.mit.edu	37	chr5	140769071	140769071	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaccagggctcgccagcgctCagcgcgaacgtgagcctgcg	15	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140769071C>G	uc003lkc.1	+	1	1620	c.1620C>G	c.(1618-1620)CTC>CTG	p.L540L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.L540L	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	540	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCAGCGCTCAGCGCGAACG	0.701													0	0	0	0.001984	0	7	50										G	140769071	C	G	140769071	2	3	96	1	0	0	0	0	0	0	0	1	11565	813	29	1		1	PCDHGB4	5	140769071	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	18574	140769071	40146189	330	28806										
PCDHGB6	56100	broad.mit.edu	37	chr5	140788139	140788139	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcatgtcattgtggtgattGaggatgttaatgaccacgcc	11	7	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:140788139G>A	uc003lkj.1	+	1	370	c.370G>A	c.(370-372)GAG>AAG	p.E124K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.E124K	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	124	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGGTGATTGAGGATGTTAA	0.398													0	0	0	0.00361	0	47	88										A	140788139	G	A	140788139	3	1	96	1	0	0	0	0	1	0	0	0	11567	1291	45	1	372	1	PCDHGB6	5	140788139	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	19068	140788139	40127121	331	28807										
ARAP3	64411	broad.mit.edu	37	chr5	141041670	141041670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacagggtcatcgagctcacGaaagaagcgtttgagtgtgt	13	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:141041670G>A	uc003llm.2	-	20	3031	c.2953C>T	c.(2953-2955)CGT>TGT	p.R985C	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Missense_Mutation_p.R647C|ARAP3_uc003lln.2_Intron	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	985	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TCGAGCTCACGAAAGAAGCGT	0.592													0	0	0	0.003954	0	22	103										A	141041670	G	A	141041670	3	1	96	1	0	0	0	0	1	0	0	0	840	1058	37	1	1737	1	ARAP3	5	141041670	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	253531	141041670	39873590	332	28808										
GRXCR2	643226	broad.mit.edu	37	chr5	145252372	145252372	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtttcaagagactcttgcaGaaaactgtgagggtattcct	10	7	2	3	rs150272088	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:145252372G>A	uc003lns.1	-	1	160	c.160C>T	c.(160-162)CTG>TTG	p.L54L		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	54											0						GACTCTTGCAGAAAACTGTGA	0.493													0	0	0	0.005524	0	40	92										A	145252372	G	A	145252372	2	1	96	1	0	0	0	0	0	0	0	1	6813	933	33	1		1	GRXCR2	5	145252372	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4210702	145252372	35662888	333	28809										
RBM27	54439	broad.mit.edu	37	chr5	145641356	145641356	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgctccttcaacagtgcacgGaggtatccagaaggtaatct	10	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:145641356G>A	uc003lnz.3	+	13	2343	c.2177G>A	c.(2176-2178)GGA>GAA	p.G726E	RBM27_uc003lny.2_Missense_Mutation_p.G671E	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	726					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACAGTGCACGGAGGTATCCAG	0.478													0	0	0	0.000978	0	11	39										A	145641356	G	A	145641356	3	1	96	1	0	0	0	0	1	0	0	0	13127	1174	41	1	2227	1	RBM27	5	145641356	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	388984	145641356	35273904	334	28810										
ARHGEF37	389337	broad.mit.edu	37	chr5	149006694	149006694	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcctgagcaggtatggccCtgggaagctgtaccaggtga	14	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:149006694C>G	uc003lra.1	+	11	1584	c.1520C>G	c.(1519-1521)CCT>CGT	p.P507R		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	507	SH3 1.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						AGGTATGGCCCTGGGAAGCTG	0.577													0	0	0	0.003954	0	25	146										G	149006694	C	G	149006694	3	3	96	1	0	0	0	0	1	0	0	0	906	681	24	4	1558	4	ARHGEF37	5	149006694	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3365338	149006694	31908566	335	28811										
TCOF1	6949	broad.mit.edu	37	chr5	149748414	149748414	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caaatactacgttggtctcaGaaactgaggaggagggcagc	13	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:149748414G>A	uc003lry.2	+	5	622	c.514G>A	c.(514-516)GAA>AAA	p.E172K	TCOF1_uc003lrw.2_Missense_Mutation_p.E172K|TCOF1_uc011dch.1_Missense_Mutation_p.E172K|TCOF1_uc003lrz.2_Missense_Mutation_p.E172K|TCOF1_uc003lrx.2_Missense_Mutation_p.E172K|TCOF1_uc003lsa.2_Missense_Mutation_p.E172K	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	172					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGGTCTCAGAAACTGAGGA	0.582													0	0	0	0.001882	0	21	54										A	149748414	G	A	149748414	3	1	96	1	0	0	0	0	1	0	0	0	15705	943	33	1	532	1	TCOF1	5	149748414	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	741720	149748414	31166846	336	28812										
LARP1	23367	broad.mit.edu	37	chr5	154173531	154173531	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggacgggggcgtggtcgcgGccggggacgcggccggggtg	25	10	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:154173531G>T	uc003lvp.2	+	6	1469	c.1040G>T	c.(1039-1041)GGC>GTC	p.G347V	LARP1_uc003lvo.2_Missense_Mutation_p.G270V|LARP1_uc010jie.1_Missense_Mutation_p.G142V	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	347							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CGTGGTCGCGGCCGGGGACGC	0.692													1	0	3.59834e-05	0.001168	4.30724e-05	6	80										T	154173531	G	T	154173531	3	4	96	1	0	0	0	0	1	0	0	0	8628	1203	42	4	831	4	LARP1	5	154173531	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4425117	154173531	26741729	337	28813										
KIF4B	285643	broad.mit.edu	37	chr5	154393975	154393975	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agactgttttagttgccttgGatactgtttcctgtttggag	11	6	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:154393975G>T	uc010jih.1	+	1	716	c.556G>T	c.(556-558)GAT>TAT	p.D186Y		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	186	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGTTGCCTTGGATACTGTTTC	0.468													1	0	0.00621372	0.006214	0.00734024	10	224										T	154393975	G	T	154393975	3	4	96	1	0	0	0	0	1	0	0	0	8304	1174	41	3	558	3	KIF4B	5	154393975	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	220444	154393975	26521285	338	28814										
TIMD4	91937	broad.mit.edu	37	chr5	156353320	156353320	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gctcaggaactgctgtatcaGatgctgggaaggaaaagaga	14	6	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:156353320G>C	uc003lwh.2	-	6	905	c.848C>G	c.(847-849)TCT>TGT	p.S283C	TIMD4_uc010jii.2_Missense_Mutation_p.S255C|TIMD4_uc003lwg.2_Translation_Start_Site	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	283	Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGCTGTATCAGATGCTGGGAA	0.358													0	0	0	0.008291	0	9	31										C	156353320	G	C	156353320	3	2	96	1	0	0	0	0	1	0	0	0	15900	942	33	1	304	1	TIMD4	5	156353320	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1959345	156353320	24561940	339	28815										
GABRA6	2559	broad.mit.edu	37	chr5	161116300	161116300	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcccatgaggctggttaacTttcctatggatgggcatgct	12	9	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:161116300T>G	uc003lyu.2	+	5	825	c.487T>G	c.(487-489)TTT>GTT	p.F163V	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	163	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCTGGTTAACTTTCCTATGGA	0.398										TCGA Ovarian(5;0.080)			0	0	0	0.004656	0	23	89										G	161116300	T	G	161116300	3	3	96	1	0	0	0	0	1	0	0	0	6165	1609	56	5	505	5	GABRA6	5	161116300	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	4762980	161116300	19798960	340	28816										
SLIT3	6586	broad.mit.edu	37	chr5	168119694	168119694	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagtggtcaatcacctcgtCgcatagctcacctggcacag	9	14	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:168119694C>T	uc003mab.2	-	29	3514	c.3094G>A	c.(3094-3096)GAC>AAC	p.D1032N	SLIT3_uc010jjg.2_Missense_Mutation_p.D1039N	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1032	EGF-like 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCACCTCGTCGCATAGCTCA	0.577													0	0	0	0.004007	0	15	36										T	168119694	C	T	168119694	3	4	96	1	0	0	0	0	1	0	0	0	14741	884	31	1	1509	1	SLIT3	5	168119694	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7003394	168119694	12795566	341	28817										
NSD1	64324	broad.mit.edu	37	chr5	176637917	176637917	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggatggtctaaaactactGaacaatatgcatgagaaaac	9	6	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:176637917G>A	uc003mfr.3	+	5	2655	c.2517G>A	c.(2515-2517)CTG>CTA	p.L839L	NSD1_uc003mft.3_Silent_p.L570L|NSD1_uc003mfs.1_Silent_p.L736L|NSD1_uc011dfx.1_Silent_p.L487L	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	839					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TAAAACTACTGAACAATATGC	0.408			T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.004007	0	16	52										A	176637917	G	A	176637917	2	1	96	1	0	0	0	0	0	0	0	1	10669	1277	45	1		1	NSD1	5	176637917	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8518223	176637917	4277343	342	28818										
PFN3	345456	broad.mit.edu	37	chr5	176827416	176827416	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcaggaaggtgtgcctgtcCggccccgtgagcacgcccac	14	15	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:176827416C>T	uc003mgl.2	-	1	222	c.162G>A	c.(160-162)CCG>CCA	p.P54P		NM_001029886	NP_001025057	P60673	PROF3_HUMAN	profilin 3	54					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTGCCTGTCCGGCCCCGTGA	0.746													0	0	0	0.000248	0	4	5										T	176827416	C	T	176827416	2	4	96	1	0	0	0	0	0	0	0	1	11769	639	23	2		2	PFN3	5	176827416	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	189499	176827416	4087844	343	28819										
COL23A1	91522	broad.mit.edu	37	chr5	177690292	177690292	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggaggtccagggggccccgGaggcccagcagctccatctt	15	14	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:177690292G>C	uc003mje.2	-	9	914	c.556C>G	c.(556-558)CCG>GCG	p.P186A	COL23A1_uc010jkt.2_Silent_p.L33L	NM_173465	NP_775736	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	186	Extracellular (Potential).|Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|skin(1)	2	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		GGGGGCCCCGGAGGCCCAGCA	0.672													0	0	0	0.001855	0	11	21										C	177690292	G	C	177690292	3	2	96	1	0	0	0	0	1	0	0	0	3682	1174	41	1	1150	1	COL23A1	5	177690292	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	862876	177690292	3224968	344	28820										
RNF130	55819	broad.mit.edu	37	chr5	179390562	179390562	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actggcaataataaaccattCttctgttgacaaaggaaagg	8	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:179390562C>T	uc003mll.1	-	8	1560	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	RNF130_uc003mlm.1_Intron	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	385	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATAAACCATTCTTCTGTTGAC	0.448													0	0	0	0.008291	0	8	11										T	179390562	C	T	179390562	3	4	96	1	0	0	0	0	1	0	0	0	13438	922	32	1	114	1	RNF130	5	179390562	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1700270	179390562	1524698	345	28821										
GFPT2	9945	broad.mit.edu	37	chr5	179745840	179745840	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaaggtctggatggctcgaGatgggtcatcactggccgag	16	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:179745840G>C	uc003mlw.1	-	10	1009	c.911C>G	c.(910-912)TCT>TGT	p.S304C		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	304					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	GATGGCTCGAGATGGGTCATC	0.607													0	0	0	0.00245	0	14	37										C	179745840	G	C	179745840	3	2	96	1	0	0	0	0	1	0	0	0	6346	942	33	1	1177	1	GFPT2	5	179745840	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	355278	179745840	1169420	346	28822										
FLT4	2324	broad.mit.edu	37	chr5	180041111	180041111	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcaccccaaaggaccacacGtcactctgcgtggtgtacac	9	15	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr5:180041111G>A	uc003mma.3	-	24	3367	c.3288C>T	c.(3286-3288)GAC>GAT	p.D1096D	FLT4_uc003mlz.3_Silent_p.D1096D	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1096	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGACCACACGTCACTCTGCG	0.622									Congenital_Hereditary_Lymphedema				0	0	0	0.003755	0	33	51										A	180041111	G	A	180041111	2	1	96	1	0	0	0	0	0	0	0	1	5944	1136	40	2		2	FLT4	5	180041111	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	295271	180041111	874149	347	28823										
RREB1	6239	broad.mit.edu	37	chr6	7229506	7229506	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggatgacaaccaggcaattCagctccagacactcaagtgt	9	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:7229506C>T	uc003mxc.2	+	10	1564	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*	RREB1_uc003mxb.2_Nonsense_Mutation_p.Q392*|RREB1_uc010jnx.2_Nonsense_Mutation_p.Q392*	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	392					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCAGGCAATTCAGCTCCAGAC	0.622													0	0	0	0.00308	0	8	38										T	7229506	C	T	7229506	4	4	96	1	0	0	0	0	0	1	0	0	13679	827	29	1	1200	1	RREB1	6	7229506	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		7229506	163885561	348	28824										
DSP	1832	broad.mit.edu	37	chr6	7583844	7583844	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccatcaagaaaaatttgattGatagagaaaccggaatgcgc	9	7	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:7583844G>C	uc003mxp.1	+	24	6628	c.6349G>C	c.(6349-6351)GAT>CAT	p.D2117H	DSP_uc003mxq.1_Missense_Mutation_p.D1518H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2117	Globular 2.|Plectin 3.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAATTTGATTGATAGAGAAAC	0.443													0	0	0	0.00632	0	27	109										C	7583844	G	C	7583844	3	2	96	1	0	0	0	0	1	0	0	0	4781	1290	45	1	6443	1	DSP	6	7583844	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	354338	7583844	163531223	349	28825										
NEDD9	4739	broad.mit.edu	37	chr6	11190647	11190647	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actcgttgcagctcccgcttCatcttgttgtggaggatgag	12	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:11190647C>T	uc003mzv.2	-	5	1622	c.1455G>A	c.(1453-1455)ATG>ATA	p.M485I	NEDD9_uc010joz.2_Missense_Mutation_p.M485I|NEDD9_uc003mzw.3_Missense_Mutation_p.M339I	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	485					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCTCCCGCTTCATCTTGTTGT	0.522													0	0	0	0.001368	0	12	38										T	11190647	C	T	11190647	3	4	96	1	0	0	0	0	1	0	0	0	10313	826	29	1	1061	1	NEDD9	6	11190647	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3606803	11190647	159924420	350	28826										
SIRT5	23408	broad.mit.edu	37	chr6	13592071	13592071	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgagtcgtggtcatcacccaGaacatcgatgagctgcaccg	11	13	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:13592071G>A	uc003nay.2	+	5	716	c.420G>A	c.(418-420)CAG>CAA	p.Q140Q	SIRT5_uc003naw.2_Silent_p.Q140Q|SIRT5_uc003nax.2_Silent_p.Q32Q|SIRT5_uc011dit.1_Silent_p.Q140Q	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	140	NAD.|Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	TCATCACCCAGAACATCGATG	0.617													0	0	0	0.001855	0	12	46										A	13592071	G	A	13592071	2	1	96	1	0	0	0	0	0	0	0	1	14341	933	33	1		1	SIRT5	6	13592071	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2401424	13592071	157522996	351	28827										
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184038	26184038	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatagcatgcctgagccagcGaaatccgctcccgccccgaa	10	16	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:26184038G>A	uc003ngt.2	+	1	15	c.15G>A	c.(13-15)GCG>GCA	p.A5A		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	5				A -> S (in Ref. 2; CAB02545).	defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CTGAGCCAGCGAAATCCGCTC	0.512													0	0	0	0.007291	0	29	73										A	26184038	G	A	26184038	2	1	96	1	0	0	0	0	0	0	0	1	7144	1045	37	1		1	HIST1H2BE	6	26184038	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	12591967	26184038	144931029	352	28828										
HIST1H2AG	8969	broad.mit.edu	37	chr6	27101075	27101075	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aacgcggcccgcgacaacaaGaagacccgcatcatcccgcg	10	17	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:27101075G>C	uc003niw.2	+	1	259	c.225G>C	c.(223-225)AAG>AAC	p.K75N	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	75					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GCGACAACAAGAAGACCCGCA	0.662													0	0	0	0.00499	0	16	91										C	27101075	G	C	27101075	3	2	96	1	0	0	0	0	1	0	0	0	7133	933	33	1	227	1	HIST1H2AG	6	27101075	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	917037	27101075	144013992	353	28829										
ZNF311	282890	broad.mit.edu	37	chr6	28966565	28966565	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggatcctgcacacaggggtCtacttctcgctccagatgag	11	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:28966565C>G	uc003nlu.2	-	6	874	c.361G>C	c.(361-363)GAC>CAC	p.D121H	ZNF311_uc011dlk.1_Missense_Mutation_p.D29H|ZNF311_uc003nlv.2_Missense_Mutation_p.D29H	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						ACACAGGGGTCTACTTCTCGC	0.448													0	0	0	0.000978	0	10	68										G	28966565	C	G	28966565	3	3	96	1	0	0	0	0	1	0	0	0	17831	913	32	1	1647	1	ZNF311	6	28966565	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1865490	28966565	142148502	354	28830										
OR11A1	26531	broad.mit.edu	37	chr6	29394644	29394644	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcagagggtgcaacataaaAgatcatgagcgttccataga	11	7	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:29394644A>G	uc003nmg.2	-	1	866	c.775T>C	c.(775-777)TTT>CTT	p.F259L		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCAACATAAAAGATCATGAGC	0.522													0	0	0	0.003163	0	15	89										G	29394644	A	G	29394644	3	3	96	1	0	0	0	0	1	0	0	0	10924	72	3	5	176	5	OR11A1	6	29394644	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	428079	29394644	141720423	355	28831										
HLA-F	3134	broad.mit.edu	37	chr6	29694183	29694183	+	Nonstop_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaatattttctctatagtgtGagacagcttccttgtgtggg	11	6	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:29694183G>T	uc010jrl.2	+	7	1164	c.1040G>T	c.(1039-1041)TGA>TTA	p.*347L	HLA-F_uc003nnm.3_Nonstop_Mutation_p.*255L|HLA-F_uc003nno.3_Intron|HLA-F_uc011dlx.1_Intron|HLA-F_uc011dly.1_Intron	NM_018950	NP_061823	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	347					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						TCTATAGTGTGAGACAGCTTC	0.353													1	0	9.70103e-10	0.008291	1.19807e-09	9	47										T	29694183	G	T	29694183	4	4	96	1	0	0	0	0	0	0	0	0	7211	1285	45	3	1066	3	HLA-F	6	29694183	Nonstop_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	299539	29694183	141420884	356	28832										
ABCF1	23	broad.mit.edu	37	chr6	30552094	30552094	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaggggatgacacagctgctGagaggctagagaaggtagag	17	5	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:30552094G>A	uc003nql.2	+	13	1323	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	ABCF1_uc003nqk.2_Missense_Mutation_p.E411K|ABCF1_uc003nqm.2_Missense_Mutation_p.E372K|ABCF1_uc010jsb.2_Intron|MIR877_hsa-mir-877|MI0005561_5'Flank	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	410	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						CACAGCTGCTGAGAGGCTAGA	0.597													0	0	0	0.001523	0	19	65										A	30552094	G	A	30552094	3	1	96	1	0	0	0	0	1	0	0	0	65	1291	45	1	1278	1	ABCF1	6	30552094	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	857911	30552094	140562973	357	28833										
BAT4	7918	broad.mit.edu	37	chr6	31631705	31631705	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagggaagccagcttcttcaGcgagctgagccgcatccctg	12	14	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:31631705G>A	uc003nvn.2	-	2	1196	c.551C>T	c.(550-552)GCT>GTT	p.A184V	BAT4_uc003nvo.3_Missense_Mutation_p.A184V|BAT4_uc003nvp.3_Missense_Mutation_p.A184V|BAT4_uc003nvq.2_Missense_Mutation_p.A184V|CSNK2B_uc010jsz.1_5'Flank|CSNK2B_uc010jta.1_5'Flank|CSNK2B_uc003nvr.1_5'Flank|CSNK2B_uc003nvs.1_5'Flank	NM_033177	NP_149417	O95872	GPAN1_HUMAN	HLA-B associated transcript 4	184						intracellular	nucleic acid binding				0						AGCTTCTTCAGCGAGCTGAGC	0.642													0	0	0	0.007413	0	19	40										A	31631705	G	A	31631705	3	1	96	1	0	0	0	0	1	0	0	0	1323	971	34	2	527	2	BAT4	6	31631705	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1079611	31631705	139483362	358	28834										
LY6G6F	259215	broad.mit.edu	37	chr6	31685395	31685395	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caccaacatccagcctgcgtCgcagcccatcattgcaatca	6	17	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:31685395C>G	uc003nwb.1	+	6	963	c.963C>G	c.(961-963)GTC>GTG	p.V321V	LY6G6D_uc003nwf.1_Silent_p.V72V|LY6G6D_uc003nwg.1_Silent_p.V51V	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	Error:Variant_position_missing_in_Q5SQ64_after_alignment						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						CAGCCTGCGTCGCAGCCCATC	0.577													0	0	0	0.00361	0	74	195										G	31685395	C	G	31685395	2	3	96	1	0	0	0	0	0	0	0	1	9096	871	31	1		1	LY6G6F	6	31685395	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	53690	31685395	139429672	359	28835										
MSH5	4439	broad.mit.edu	37	chr6	31711763	31711763	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actgccactgagaaaatcctCttcctctcttccattattcc	3	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:31711763C>G	uc003nwv.1	+	6	577	c.498C>G	c.(496-498)CTC>CTG	p.L166L	MSH5_uc003nwt.1_Silent_p.L166L|MSH5_uc003nwu.1_Silent_p.L166L|MSH5_uc003nww.1_Silent_p.L166L|MSH5_uc003nwx.1_Silent_p.L166L|MSH5_uc011dof.1_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	166					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						AGAAAATCCTCTTCCTCTCTT	0.517								Direct_reversal_of_damage|MMR					0	0	0	0.005524	0	37	228										G	31711763	C	G	31711763	2	3	96	1	0	0	0	0	0	0	0	1	9873	900	32	1		1	MSH5	6	31711763	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	26368	31711763	139403304	360	28836										
TNXB	7148	broad.mit.edu	37	chr6	32026081	32026081	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggatcctgtcactgtcagctCccccaggagaggctcctcgg	12	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:32026081C>T	uc003nzl.2	-	22	7781	c.7579G>A	c.(7579-7581)GAG>AAG	p.E2527K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2587	Fibronectin type-III 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACTGTCAGCTCCCCCAGGAGA	0.627													0	0	0	0.00308	0	8	32										T	32026081	C	T	32026081	3	4	96	1	0	0	0	0	1	0	0	0	16343	864	30	1	7226	1	TNXB	6	32026081	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	314318	32026081	139088986	361	28837										
PHF1	5252	broad.mit.edu	37	chr6	33380560	33380560	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggctggtcagctgtgagaaGtgtcgccatggtgagagggc	18	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33380560G>A	uc003oeh.2	+	4	563	c.327G>A	c.(325-327)AAG>AAA	p.K109K	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Silent_p.K109K|PHF1_uc010jux.2_Intron	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	109	PHD-type 1.				chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				GCTGTGAGAAGTGTCGCCATG	0.577													0	0	0	0.008871	0	19	50										A	33380560	G	A	33380560	2	1	96	1	0	0	0	0	0	0	0	1	11820	1020	36	2		2	PHF1	6	33380560	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1354479	33380560	137734507	362	28838										
PHF1	5252	broad.mit.edu	37	chr6	33383647	33383647	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctaaaagtgccccccactcGatgactgcctcatcttcctc	5	18	2	1	rs138734488		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33383647G>C	uc003oeh.2	+	15	1712	c.1476G>C	c.(1474-1476)TCG>TCC	p.S492S	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.R457P|PHF1_uc010jux.2_Silent_p.S292S	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	492					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CCCCCCACTCGATGACTGCCT	0.542													0	0	0	0.003755	0	32	105										C	33383647	G	C	33383647	2	2	96	1	0	0	0	0	0	0	0	1	11820	1058	37	1		1	PHF1	6	33383647	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3087	33383647	137731420	363	28839										
PHF1	5252	broad.mit.edu	37	chr6	33383743	33383743	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgccgtagtttgtctcctggGactgggggaggagtccgagg	18	8	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33383743G>A	uc003oeh.2	+	15	1808	c.1572G>A	c.(1570-1572)GGG>GGA	p.G524G	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_3'UTR|PHF1_uc010jux.2_Silent_p.G324G	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	524					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				TGTCTCCTGGGACTGGGGGAG	0.612													0	0	0	0.003755	0	36	101										A	33383743	G	A	33383743	2	1	96	1	0	0	0	0	0	0	0	1	11820	1161	41	1		1	PHF1	6	33383743	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	96	33383743	137731324	364	28840										
PHF1	5252	broad.mit.edu	37	chr6	33383754	33383754	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtctcctgggactgggggagGagtccgaggtggggttggtt	21	6	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:33383754G>C	uc003oeh.2	+	15	1819	c.1583G>C	c.(1582-1584)GGA>GCA	p.G528A	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_3'UTR|PHF1_uc010jux.2_Missense_Mutation_p.G328A	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	528					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				ACTGGGGGAGGAGTCCGAGGT	0.617													0	0	0	0.00278	0	22	123										C	33383754	G	C	33383754	3	2	96	1	0	0	0	0	1	0	0	0	11820	1174	41	1	1637	1	PHF1	6	33383754	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	11	33383754	137731313	365	28841										
USP49	25862	broad.mit.edu	37	chr6	41774070	41774070	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgaggcagccgggcccgcgtCgcggggcgtgtgcaggagca	20	13	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:41774070C>T	uc003ori.2	-	4	874	c.652G>A	c.(652-654)GAC>AAC	p.D218N		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	218					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			gggcccgcgtcgcggggcgTG	0.577													0	0	0	0.00308	0	8	12										T	41774070	C	T	41774070	3	4	96	1	0	0	0	0	1	0	0	0	17077	884	31	1	1286	1	USP49	6	41774070	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	8390316	41774070	129340997	366	28842										
UBR2	23304	broad.mit.edu	37	chr6	42655960	42655960	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttatcccttggaggtgcccGaaatcaggtggtgataagag	13	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:42655960G>A	uc011dur.1	+	45	4860	c.4860G>A	c.(4858-4860)CCG>CCA	p.P1620P	UBR2_uc011dus.1_Silent_p.P1265P|UBR2_uc003osh.2_RNA|UBR2_uc011dut.1_Silent_p.P208P|UBR2_uc011duu.1_Silent_p.P12P	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1620					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GGAGGTGCCCGAAATCAGGTG	0.428													0	0	0	0.004007	0	17	119										A	42655960	G	A	42655960	2	1	96	1	0	0	0	0	0	0	0	1	16899	1045	37	1		1	UBR2	6	42655960	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	881890	42655960	128459107	367	28843										
CUL9	23113	broad.mit.edu	37	chr6	43172787	43172787	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgggcctcgggcagccttCatgctggctctgcgcagtgg	15	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:43172787C>T	uc003ouk.2	+	23	4641	c.4566C>T	c.(4564-4566)TTC>TTT	p.F1522F	CUL9_uc003oul.2_Silent_p.F1522F|CUL9_uc010jyk.2_Silent_p.F674F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1522					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGGCAGCCTTCATGCTGGCTC	0.602													0	0	0	0.004656	0	26	59										T	43172787	C	T	43172787	2	4	96	1	0	0	0	0	0	0	0	1	4061	825	29	1		1	CUL9	6	43172787	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	516827	43172787	127942280	368	28844										
CAPN11	11131	broad.mit.edu	37	chr6	44148506	44148506	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaaggagataggggtgtatGagctccagaggctgctcaac	15	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:44148506G>A	uc003owt.1	+	17	1806	c.1768G>A	c.(1768-1770)GAG>AAG	p.E590K	CAPN11_uc011dvn.1_Missense_Mutation_p.E244K	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	590	Domain IV.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGGGGTGTATGAGCTCCAGAG	0.602													0	0	0	0.00245	0	12	46										A	44148506	G	A	44148506	3	1	96	1	0	0	0	0	1	0	0	0	2624	1291	45	1	1834	1	CAPN11	6	44148506	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	975719	44148506	126966561	369	28845										
HSP90AB1	3326	broad.mit.edu	37	chr6	44219877	44219877	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgatgggaagagcctggtctCagttaccaaggagggtctgg	16	7	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:44219877C>G	uc003oxa.1	+	10	1688	c.1604C>G	c.(1603-1605)TCA>TGA	p.S535*	HSP90AB1_uc011dvr.1_Nonsense_Mutation_p.S525*|HSP90AB1_uc003oxb.1_Nonsense_Mutation_p.S535*|HSP90AB1_uc011dvs.1_Nonsense_Mutation_p.S355*|HSP90AB1_uc003oxc.1_Nonsense_Mutation_p.S173*	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	535					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGCCTGGTCTCAGTTACCAAG	0.517													0	0	0	0.001984	0	7	38										G	44219877	C	G	44219877	4	3	96	1	0	0	0	0	0	1	0	0	7402	838	29	1	1638	1	HSP90AB1	6	44219877	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	71371	44219877	126895190	370	28846										
TDRD6	221400	broad.mit.edu	37	chr6	46660346	46660346	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttctacccaagtaattaaaaGtgccagttcaaagtctgtta	6	8	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46660346G>C	uc003oyj.2	+	1	4481	c.4481G>C	c.(4480-4482)AGT>ACT	p.S1494T	TDRD6_uc010jze.2_Missense_Mutation_p.S1488T	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1494					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTAATTAAAAGTGCCAGTTCA	0.348													0	0	0	0.008291	0	10	68										C	46660346	G	C	46660346	3	2	96	1	0	0	0	0	1	0	0	0	15731	1029	36	4	4483	4	TDRD6	6	46660346	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2440469	46660346	124454721	371	28847			2	129		5	5	5395	N	G_C	3.403872e-05
TDRD6	221400	broad.mit.edu	37	chr6	46660716	46660716	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtgtggacccaaaagcactCtgggccattccttctgaact	9	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46660716C>G	uc003oyj.2	+	1	4851	c.4851C>G	c.(4849-4851)CTC>CTG	p.L1617L	TDRD6_uc010jze.2_Silent_p.L1611L	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1617	Tudor 7.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CAAAAGCACTCTGGGCCATTC	0.423													0	0	0	0.001523	0	17	81										G	46660716	C	G	46660716	2	3	96	1	0	0	0	0	0	0	0	1	15731	900	32	1		1	TDRD6	6	46660716	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	370	46660716	124454351	372	28848			2	129		5	5	5395	N	G_C	3.403872e-05
TDRD6	221400	broad.mit.edu	37	chr6	46660747	46660747	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttctgaacttctgtcggttCccatgcaagcctttccatgt	7	13	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46660747C>G	uc003oyj.2	+	1	4882	c.4882C>G	c.(4882-4884)CCC>GCC	p.P1628A	TDRD6_uc010jze.2_Missense_Mutation_p.P1622A	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1628					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TCTGTCGGTTCCCATGCAAGC	0.413													0	0	0	0.001882	0	22	67										G	46660747	C	G	46660747	3	3	96	1	0	0	0	0	1	0	0	0	15731	855	30	1	4884	1	TDRD6	6	46660747	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	31	46660747	124454320	373	28849			2	129		5	5	5395	N	G_C	3.403872e-05
TDRD6	221400	broad.mit.edu	37	chr6	46661399	46661399	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gctttctcctgatgatgaatCaaaagaattcttagaactgg	8	7	3	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46661399C>G	uc003oyj.2	+	1	5534	c.5534C>G	c.(5533-5535)TCA>TGA	p.S1845*	TDRD6_uc010jze.2_Nonsense_Mutation_p.S1839*	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1845					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GATGATGAATCAAAAGAATTC	0.418													0	0	0	0.000978	0	11	71										G	46661399	C	G	46661399	4	3	96	1	0	0	0	0	0	1	0	0	15731	838	29	1	5536	1	TDRD6	6	46661399	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	652	46661399	124453668	374	28850			2	129		5	5	5395	N	G_C	3.403872e-05
TDRD6	221400	broad.mit.edu	37	chr6	46665740	46665740	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgttttctcctgtaggttttGaacctttcaaatggtatgga	9	6	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46665740G>C	uc003oyj.2	+	3	6177	c.6177G>C	c.(6175-6177)TTG>TTC	p.L2059F	TDRD6_uc010jze.2_Intron	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	2059	Tudor 8.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TGTAGGTTTTGAACCTTTCAA	0.308													0	0	0	0.002096	0	28	135										C	46665740	G	C	46665740	3	2	96	1	0	0	0	0	1	0	0	0	15731	1281	45	1	6187	1	TDRD6	6	46665740	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4341	46665740	124449327	375	28851			2	129		5	5	5395	N	G_C	3.403872e-05
GPR110	266977	broad.mit.edu	37	chr6	46996735	46996735	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tagcaccaactcacccccagGaagccaccgtggccgtcagt	9	17	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:46996735G>A	uc003oyt.2	-	2	262	c.63C>T	c.(61-63)TTC>TTT	p.F21F	GPR110_uc011dwl.1_5'UTR|GPR110_uc003oyu.1_Silent_p.F21F	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	21	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TCACCCCCAGGAAGCCACCGT	0.517													0	0	0	0.000978	0	9	51										A	46996735	G	A	46996735	2	1	96	1	0	0	0	0	0	0	0	1	6627	1165	41	1		1	GPR110	6	46996735	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	330995	46996735	124118332	376	28852										
PGK2	5232	broad.mit.edu	37	chr6	49754286	49754286	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtatagccagaaagggtctCactgggttttccaaggcttt	11	8	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:49754286C>T	uc003ozu.2	-	1	722	c.615G>A	c.(613-615)GTG>GTA	p.V205V		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	205					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GAAAGGGTCTCACTGGGTTTT	0.433													0	0	0	0.006122	0	19	80										T	49754286	C	T	49754286	2	4	96	1	0	0	0	0	0	0	0	1	11791	813	29	1		1	PGK2	6	49754286	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2757551	49754286	121360781	377	28853										
FAM83B	222584	broad.mit.edu	37	chr6	54805774	54805774	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcgaagtttcccgttatttGacaactcaaaagccaactta	7	10	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:54805774G>C	uc003pck.2	+	5	2121	c.2005G>C	c.(2005-2007)GAC>CAC	p.D669H		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	669										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CCCGTTATTTGACAACTCAAA	0.343													0	0	0	0.007413	0	17	65										C	54805774	G	C	54805774	3	2	96	1	0	0	0	0	1	0	0	0	5634	1290	45	1	2019	1	FAM83B	6	54805774	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5051488	54805774	116309293	378	28854										
KCNQ5	56479	broad.mit.edu	37	chr6	73751754	73751754	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaggatggcaaggaagactGaggtttgctcgaaagccctt	14	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:73751754G>A	uc003pgk.2	+	3	932	c.585G>A	c.(583-585)CTG>CTA	p.L195L	KCNQ5_uc003pgj.3_Silent_p.L195L|KCNQ5_uc011dyh.1_Silent_p.L195L|KCNQ5_uc011dyi.1_Silent_p.L195L|KCNQ5_uc010kat.2_Silent_p.L195L|KCNQ5_uc011dyj.1_Silent_p.L195L|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	195					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AAGGAAGACTGAGGTTTGCTC	0.438													0	0	0	0.007291	0	27	122										A	73751754	G	A	73751754	2	1	96	1	0	0	0	0	0	0	0	1	8086	1277	45	1		1	KCNQ5	6	73751754	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	18945980	73751754	97363313	379	28855										
KCNQ5	56479	broad.mit.edu	37	chr6	73904609	73904609	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccacctcctctcccagccatCaagcatctgcccaggccaga	6	20	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:73904609C>G	uc003pgk.2	+	14	2618	c.2271C>G	c.(2269-2271)ATC>ATG	p.I757M	KCNQ5_uc011dyh.1_Missense_Mutation_p.I776M|KCNQ5_uc011dyi.1_Missense_Mutation_p.I767M|KCNQ5_uc010kat.2_Missense_Mutation_p.I748M|KCNQ5_uc011dyj.1_Missense_Mutation_p.I647M|KCNQ5_uc011dyk.1_Missense_Mutation_p.I507M	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	757					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TCCCAGCCATCAAGCATCTGC	0.537													0	0	0	0.007413	0	17	34										G	73904609	C	G	73904609	3	3	96	1	0	0	0	0	1	0	0	0	8086	816	29	1	2386	1	KCNQ5	6	73904609	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	152855	73904609	97210458	380	28856										
C6orf150	115004	broad.mit.edu	37	chr6	74150012	74150012	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttgcttcctaacttttgctGaaagccagttttgaatgcgc	9	9	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:74150012G>T	uc003pgx.1	-	3	1173	c.1034C>A	c.(1033-1035)TCA>TAA	p.S345*		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	345											0						AACTTTTGCTGAAAGCCAGTT	0.393													1	0	1.2476e-16	0.00632	1.57315e-16	30	76										T	74150012	G	T	74150012	4	4	96	1	0	0	0	0	0	1	0	0	2337	1294	45	3	546	3	C6orf150	6	74150012	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	245403	74150012	96965055	381	28857										
CD109	135228	broad.mit.edu	37	chr6	74502507	74502507	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ataatttgaaagaaaaagctCtttcatttatgaggcaaggt	8	4	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:74502507C>T	uc003php.2	+	23	3285	c.2860C>T	c.(2860-2862)CTT>TTT	p.L954F	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.L954F|CD109_uc010kba.2_Missense_Mutation_p.L877F	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	954						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						AGAAAAAGCTCTTTCATTTAT	0.303													0	0	0	0.006214	0	10	35										T	74502507	C	T	74502507	3	4	96	1	0	0	0	0	1	0	0	0	2963	913	32	1	2950	1	CD109	6	74502507	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	352495	74502507	96612560	382	28858										
COL12A1	1303	broad.mit.edu	37	chr6	75831126	75831126	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctccaggaggcatcagtcaaGaacacaatatctgccttggc	9	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:75831126G>C	uc003phs.2	-	44	7144	c.6978C>G	c.(6976-6978)TTC>TTG	p.F2326L	COL12A1_uc003pht.2_Missense_Mutation_p.F1162L	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2326	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CATCAGTCAAGAACACAATAT	0.388													0	0	0	0.00632	0	25	79										C	75831126	G	C	75831126	3	2	96	1	0	0	0	0	1	0	0	0	3669	933	33	1	2305	1	COL12A1	6	75831126	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1328619	75831126	95283941	383	28859										
MDN1	23195	broad.mit.edu	37	chr6	90442463	90442463	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtgggtcagccagtcaatGaaatccagcatcacttcagg	11	10	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:90442463G>A	uc003pnn.1	-	34	4871	c.4755C>T	c.(4753-4755)TTC>TTT	p.F1585F		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1585					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCCAGTCAATGAAATCCAGCA	0.438													0	0	0	0.003163	0	14	88										A	90442463	G	A	90442463	2	1	96	1	0	0	0	0	0	0	0	1	9415	1281	45	1		1	MDN1	6	90442463	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	14611337	90442463	80672604	384	28860										
CASP8AP2	9994	broad.mit.edu	37	chr6	90577917	90577917	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttaaagatgcttcagataaGatgggtcatagtgatgaagt	11	4	2	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:90577917G>C	uc003pnr.2	+	8	5104	c.4908G>C	c.(4906-4908)AAG>AAC	p.K1636N	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.K1636N|CASP8AP2_uc011dzz.1_Missense_Mutation_p.K1636N	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1636					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTTCAGATAAGATGGGTCATA	0.368													0	0	0	0.003163	0	14	45										C	90577917	G	C	90577917	3	2	96	1	0	0	0	0	1	0	0	0	2678	933	33	1	4934	1	CASP8AP2	6	90577917	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	135454	90577917	80537150	385	28861										
GPR63	81491	broad.mit.edu	37	chr6	97247300	97247300	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctttttggtaaaccatgaggCaaacaaccaagttcccaaga	7	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:97247300C>A	uc010kcl.2	-	3	786	c.308G>T	c.(307-309)TGC>TTC	p.C103F	GPR63_uc003pou.2_Missense_Mutation_p.C103F	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	103	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AACCATGAGGCAAACAACCAA	0.443													1	0	3.45872e-05	0.004007	4.147e-05	16	44										A	97247300	C	A	97247300	3	1	96	1	0	0	0	0	1	0	0	0	6704	710	25	4	955	4	GPR63	6	97247300	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6669383	97247300	73867767	386	28862										
MICAL1	64780	broad.mit.edu	37	chr6	109769984	109769984	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcacacagagctagcccatCagcccaggaggaagacaaat	11	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:109769984C>T	uc003ptj.2	-	11	1869	c.1615G>A	c.(1615-1617)GAT>AAT	p.D539N	MICAL1_uc003ptk.2_Missense_Mutation_p.D539N|MICAL1_uc010kdr.2_Missense_Mutation_p.D453N|MICAL1_uc011eaq.1_Missense_Mutation_p.D558N	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	539	CH.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		GCTAGCCCATCAGCCCAGGAG	0.622													0	0	0	0.00361	0	56	122										T	109769984	C	T	109769984	3	4	96	1	0	0	0	0	1	0	0	0	9569	826	29	1	1644	1	MICAL1	6	109769984	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	12522684	109769984	61345083	387	28863										
RWDD1	51389	broad.mit.edu	37	chr6	116892761	116892761	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccacgatgacagattacggcGaggagcagcgcaacgagctg	14	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:116892761G>A	uc003pxd.2	+	1	179	c.16G>A	c.(16-18)GAG>AAG	p.E6K	RWDD1_uc003pxb.2_5'UTR|RWDD1_uc003pxc.2_5'UTR	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	6							protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		AGATTACGGCGAGGAGCAGCG	0.677													0	0	0	0.004482	0	7	36										A	116892761	G	A	116892761	3	1	96	1	0	0	0	0	1	0	0	0	13754	1059	37	1	18	1	RWDD1	6	116892761	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7122777	116892761	54222306	388	28864										
RWDD1	51389	broad.mit.edu	37	chr6	116914217	116914217	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agctggaggatgatgaagatGatccagactataatcctgct	11	7	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:116914217G>A	uc003pxd.2	+	7	848	c.685G>A	c.(685-687)GAT>AAT	p.D229N	RWDD1_uc003pxb.2_Missense_Mutation_p.D133N|RWDD1_uc003pxc.2_Missense_Mutation_p.D133N	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	229							protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TGATGAAGATGATCCAGACTA	0.468													0	0	0	0.000978	0	12	50										A	116914217	G	A	116914217	3	1	96	1	0	0	0	0	1	0	0	0	13754	1290	45	1	711	1	RWDD1	6	116914217	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	21456	116914217	54200850	389	28865										
RSPH4A	345895	broad.mit.edu	37	chr6	116938321	116938321	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aacagaaagagctgagatttGacgtttttcaggaggaagac	12	5	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:116938321G>A	uc003pxe.2	+	1	680	c.535G>A	c.(535-537)GAC>AAC	p.D179N	RSPH4A_uc010kee.2_Missense_Mutation_p.D179N	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	179					cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						GCTGAGATTTGACGTTTTTCA	0.502									Kartagener_syndrome				0	0	0	0.004656	0	26	155										A	116938321	G	A	116938321	3	1	96	1	0	0	0	0	1	0	0	0	13706	1290	45	1	537	1	RSPH4A	6	116938321	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	24104	116938321	54176746	390	28866										
GPRC6A	222545	broad.mit.edu	37	chr6	117127555	117127555	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccatggttgaaaggcgttgGggttctgacagtcacgagct	14	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:117127555G>A	uc003pxj.1	-	3	1335	c.1313C>T	c.(1312-1314)CCC>CTC	p.P438L	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.P438L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	438	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AAAGGCGTTGGGGTTCTGACA	0.448													0	0	0	0.000978	0	12	50										A	117127555	G	A	117127555	3	1	96	1	0	0	0	0	1	0	0	0	6728	1232	43	2	1483	2	GPRC6A	6	117127555	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	189234	117127555	53987512	391	28867										
HSF2	3298	broad.mit.edu	37	chr6	122743440	122743440	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggatgttatatctgatccctCcaagtaaggagtttgtgaga	11	6	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:122743440C>G	uc003pyu.2	+	8	1014	c.827C>G	c.(826-828)TCC>TGC	p.S276C	HSF2_uc003pyv.2_Missense_Mutation_p.S276C	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	276					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TCTGATCCCTCCAAGTAAGGA	0.274													0	0	0	0.00361	0	43	165										G	122743440	C	G	122743440	3	3	96	1	0	0	0	0	1	0	0	0	7396	855	30	1	857	1	HSF2	6	122743440	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5615885	122743440	48371627	392	28868										
CTGF	1490	broad.mit.edu	37	chr6	132271151	132271151	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcacaggcggctctgcttctCtagcctgcaggaggcgttgt	14	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:132271151C>G	uc003qcz.2	-	4	897	c.691G>C	c.(691-693)GAG>CAG	p.E231Q		NM_001901	NP_001892	P29279	CTGF_HUMAN	connective tissue growth factor precursor	231	TSP type-1.				cellular lipid metabolic process|DNA replication|epidermis development|regulation of cell growth|response to wounding	plasma membrane|proteinaceous extracellular matrix	heparin binding|insulin-like growth factor binding				0	Breast(56;0.0602)			GBM - Glioblastoma multiforme(226;0.015)|OV - Ovarian serous cystadenocarcinoma(155;0.0169)		CTCTGCTTCTCTAGCCTGCAG	0.537											OREG0017666	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	14	31										G	132271151	C	G	132271151	3	3	96	1	0	0	0	0	1	0	0	0	4008	922	32	1	366	1	CTGF	6	132271151	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9527711	132271151	38843916	393	28869										
AHI1	54806	broad.mit.edu	37	chr6	135679284	135679284	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttaccgttggtgctgtatCtacctgatggttacaaggct	10	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:135679284C>G	uc003qgi.2	-	24	3535	c.3151G>C	c.(3151-3153)GAT>CAT	p.D1051H	AHI1_uc003qgf.2_RNA|AHI1_uc003qgg.2_Missense_Mutation_p.D501H|AHI1_uc003qgh.2_Missense_Mutation_p.D1051H|AHI1_uc003qgj.2_Missense_Mutation_p.D1051H|AHI1_uc003qgk.3_RNA	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	1051	SH3.					adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		GGTGCTGTATCTACCTGATGG	0.353													0	0	0	0.00361	0	75	295										G	135679284	C	G	135679284	3	3	96	1	0	0	0	0	1	0	0	0	413	913	32	1	463	1	AHI1	6	135679284	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3408133	135679284	35435783	394	28870										
MAP7	9053	broad.mit.edu	37	chr6	136681163	136681163	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggttcttttcataatctcctCaagtcgctataggaaaggaa	8	8	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:136681163C>G	uc003qgz.2	-	14	2056	c.1810G>C	c.(1810-1812)GAG>CAG	p.E604Q	MAP7_uc011edf.1_Missense_Mutation_p.E589Q|MAP7_uc011edg.1_Missense_Mutation_p.E634Q|MAP7_uc010kgu.2_Missense_Mutation_p.E626Q|MAP7_uc011edh.1_Missense_Mutation_p.E589Q|MAP7_uc010kgv.2_Missense_Mutation_p.E626Q|MAP7_uc010kgs.2_Missense_Mutation_p.E458Q|MAP7_uc011edi.1_Missense_Mutation_p.E458Q|MAP7_uc010kgq.1_Missense_Mutation_p.E510Q|MAP7_uc003qha.1_Missense_Mutation_p.E567Q	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	604	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		ATAATCTCCTCAAGTCGCTAT	0.343													0	0	0	0.006122	0	18	51										G	136681163	C	G	136681163	3	3	96	1	0	0	0	0	1	0	0	0	9266	835	29	1	459	1	MAP7	6	136681163	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1001879	136681163	34433904	395	28871										
KIAA1244	57221	broad.mit.edu	37	chr6	138612877	138612877	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgctctttctagggtgtgtGaatacgtgggcaccctggag	15	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:138612877G>C	uc003qhu.2	+	19	3055	c.3055G>C	c.(3055-3057)GAA>CAA	p.E1019Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1019					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TAGGGTGTGTGAATACGTGGG	0.602													0	0	0	0.000248	0	4	13										C	138612877	G	C	138612877	3	2	96	1	0	0	0	0	1	0	0	0	8217	1291	45	1	3129	1	KIAA1244	6	138612877	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1931714	138612877	32502190	396	28872										
TAB2	23118	broad.mit.edu	37	chr6	149700238	149700238	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcagcgaatgctgccacagGagatgaacaggtcatgcgga	13	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:149700238G>C	uc003qmj.2	+	3	1365	c.1187G>C	c.(1186-1188)GGA>GCA	p.G396A	TAB2_uc011eec.1_Missense_Mutation_p.G364A|TAB2_uc010kia.1_Missense_Mutation_p.G396A|TAB2_uc010kib.1_Missense_Mutation_p.G396A|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	396					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						GCTGCCACAGGAGATGAACAG	0.512													0	0	0	0.008291	0	10	45										C	149700238	G	C	149700238	3	2	96	1	0	0	0	0	1	0	0	0	15493	1174	41	1	1193	1	TAB2	6	149700238	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	11087361	149700238	21414829	397	28873										
TAB2	23118	broad.mit.edu	37	chr6	149730837	149730837	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attcgctgtgaacagtgtgaGatgccaaggcatttctgagc	12	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:149730837G>C	uc003qmj.2	+	7	2242	c.2064G>C	c.(2062-2064)GAG>GAC	p.E688D	TAB2_uc011eec.1_Missense_Mutation_p.E656D|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	688	RanBP2-type.				activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						AACAGTGTGAGATGCCAAGGC	0.433													0	0	0	0.005524	0	36	100										C	149730837	G	C	149730837	3	2	96	1	0	0	0	0	1	0	0	0	15493	933	33	1	2086	1	TAB2	6	149730837	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	30599	149730837	21384230	398	28874										
SYNE1	23345	broad.mit.edu	37	chr6	152551728	152551728	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagaagcctgatctccaattCgatgctgttgttttagtctc	8	10	2	2	rs143639400		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:152551728C>G	uc010kiw.2	-	115	21751	c.21149G>C	c.(21148-21150)CGA>CCA	p.R7050P	SYNE1_uc010kiv.2_Missense_Mutation_p.R1574P|SYNE1_uc003qos.3_Missense_Mutation_p.R1574P|SYNE1_uc003qot.3_Missense_Mutation_p.R6979P|SYNE1_uc003qou.3_Missense_Mutation_p.R7050P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7050	Cytoplasmic (Potential).|Spectrin 22.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCTCCAATTCGATGCTGTTG	0.393										HNSCC(10;0.0054)			0	0	0	0.004656	0	25	131										G	152551728	C	G	152551728	3	3	96	1	0	0	0	0	1	0	0	0	15442	884	31	1	5445	1	SYNE1	6	152551728	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2820891	152551728	18563339	399	28875										
SYTL3	94120	broad.mit.edu	37	chr6	159181754	159181754	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggttctcccttcacggcccaGaaaactccaagaggctcaag	9	14	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:159181754G>A	uc003qrp.2	+	14	1635	c.1391G>A	c.(1390-1392)AGA>AAA	p.R464K	SYTL3_uc011efp.1_Missense_Mutation_p.R464K|SYTL3_uc003qro.2_Missense_Mutation_p.R396K|SYTL3_uc003qrq.2_Missense_Mutation_p.R396K|SYTL3_uc003qrr.2_Missense_Mutation_p.R464K|SYTL3_uc003qrs.2_Missense_Mutation_p.R396K|SYTL3_uc011efq.1_Missense_Mutation_p.R190K	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	464					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCACGGCCCAGAAAACTCCAA	0.567													0	0	0	0.006122	0	17	41										A	159181754	G	A	159181754	3	1	96	1	0	0	0	0	1	0	0	0	15481	942	33	1	1225	1	SYTL3	6	159181754	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6630026	159181754	11933313	400	28876										
SYTL3	94120	broad.mit.edu	37	chr6	159184504	159184504	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatcaggccctctttggaatGaacgaccgcttgcttggagg	13	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:159184504G>T	uc003qrp.2	+	16	1930	c.1686G>T	c.(1684-1686)ATG>ATT	p.M562I	SYTL3_uc011efp.1_Missense_Mutation_p.M562I|SYTL3_uc003qro.2_Missense_Mutation_p.M494I|SYTL3_uc003qrq.2_Missense_Mutation_p.M494I|SYTL3_uc003qrr.2_Missense_Mutation_p.M562I|SYTL3_uc003qrs.2_Missense_Mutation_p.M494I|SYTL3_uc011efq.1_Missense_Mutation_p.M288I	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	562	C2 2.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCTTTGGAATGAACGACCGCT	0.488													1	0	1.5842e-08	0.001855	1.93326e-08	13	85										T	159184504	G	T	159184504	3	4	96	1	0	0	0	0	1	0	0	0	15481	1290	45	3	1528	3	SYTL3	6	159184504	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2750	159184504	11930563	401	28877										
RPS6KA2	6196	broad.mit.edu	37	chr6	166844058	166844058	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggagctccccaccacgcatCagctccattaccaggtacac	7	17	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr6:166844058C>T	uc003qvb.1	-	16	1683	c.1464G>A	c.(1462-1464)CTG>CTA	p.L488L	RPS6KA2_uc011ego.1_Silent_p.L399L|RPS6KA2_uc010kkl.1_Silent_p.L399L|RPS6KA2_uc003qvc.1_Silent_p.L496L|RPS6KA2_uc003qvd.1_Silent_p.L513L	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	488	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CACCACGCATCAGCTCCATTA	0.577													0	0	0	0.00245	0	14	45										T	166844058	C	T	166844058	2	4	96	1	0	0	0	0	0	0	0	1	13651	813	29	1		1	RPS6KA2	6	166844058	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7659554	166844058	4271009	402	28878										
TTYH3	80727	broad.mit.edu	37	chr7	2701309	2701309	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtctccctccagtacacctCcagcatgagagccaaatacc	6	16	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:2701309C>G	uc003smp.2	+	14	1695	c.1508C>G	c.(1507-1509)TCC>TGC	p.S503C	TTYH3_uc010ksn.2_Missense_Mutation_p.S223C|TTYH3_uc003smq.2_Missense_Mutation_p.S332C	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	503	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CAGTACACCTCCAGCATGAGA	0.682													0	0	0	0.004482	0	8	15										G	2701309	C	G	2701309	3	3	96	1	0	0	0	0	1	0	0	0	16738	855	30	1	1562	1	TTYH3	7	2701309	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		2701309	156437354	403	28879										
CARD11	84433	broad.mit.edu	37	chr7	2957020	2957020	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttctggctgcagggtgttCtgaaatgaatttatcaatca	9	7	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:2957020C>G	uc003smv.2	-	20	3012	c.2608_splice	c.e20-1	p.N870_splice		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11						positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GCAGGGTGTTCTGAAATGAAT	0.562			Mis		DLBCL								0	0	0	0.007413	0	19	45										G	2957020	C	G	2957020	5	3	96	1	0	0	0	0	0	0	1	0	2645	927	32	1	881	1	CARD11	7	2957020	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	255711	2957020	156181643	404	28880										
MIOS	54468	broad.mit.edu	37	chr7	7622975	7622975	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attcgccgagcaatccaaatCctgaatgaaggggcatcttc	9	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:7622975C>G	uc003srf.2	+	6	1928	c.1620C>G	c.(1618-1620)ATC>ATG	p.I540M	MIOS_uc003srg.2_Missense_Mutation_p.I75M|MIOS_uc010ktq.2_5'Flank	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	540											0						CAATCCAAATCCTGAATGAAG	0.388													0	0	0	0.001855	0	12	52										G	7622975	C	G	7622975	3	3	96	1	0	0	0	0	1	0	0	0	9589	845	30	1	1630	1	MIOS	7	7622975	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4665955	7622975	151515688	405	28881										
THSD7A	221981	broad.mit.edu	37	chr7	11468661	11468661	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaacgaaccttcacaccactCccacaggacttgctgcagcg	8	16	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:11468661C>G	uc003ssf.3	-	14	3408	c.3156G>C	c.(3154-3156)GGG>GGC	p.G1052G		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1052	TSP type-1 11.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCACACCACTCCCACAGGACT	0.517										HNSCC(18;0.044)			0	0	0	0.00361	0	95	283										G	11468661	C	G	11468661	2	3	96	1	0	0	0	0	0	0	0	1	15876	842	30	1		1	THSD7A	7	11468661	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3845686	11468661	147670002	406	28882										
HOXA10	3206	broad.mit.edu	37	chr7	27211670	27211670	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taggcgccgctctcgagtaaGgtacatattgaacagaaact	10	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:27211670G>T	uc011jzm.1	-	2	1111	c.1081C>A	c.(1081-1083)CTT>ATT	p.L361I	MIR196B_hsa-mir-196b|MI0001150_5'Flank|HOXA10_uc003syw.3_Missense_Mutation_p.L45I	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	361	Homeobox.				spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTCGAGTAAGGTACATATTG	0.522													1	0	1.52378e-38	0.00361	1.95217e-38	75	696										T	27211670	G	T	27211670	3	4	96	1	0	0	0	0	1	0	0	0	7289	1000	35	4	155	4	HOXA10	7	27211670	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	15743009	27211670	131926993	407	28883										
KBTBD2	25948	broad.mit.edu	37	chr7	32909880	32909880	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accccctgctatgtagatatCattatcaggagttacaacgg	8	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:32909880C>G	uc003tdb.2	-	4	1608	c.949G>C	c.(949-951)GAT>CAT	p.D317H	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	317	Kelch 1.										0			GBM - Glioblastoma multiforme(11;0.0499)			ATGTAGATATCATTATCAGGA	0.413													0	0	0	0.00632	0	28	83										G	32909880	C	G	32909880	3	3	96	1	0	0	0	0	1	0	0	0	7993	826	29	1	926	1	KBTBD2	7	32909880	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5698210	32909880	126228783	408	28884										
C7orf25	79020	broad.mit.edu	37	chr7	42949965	42949965	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcccatttctttcagcttctCtgccatggggctggagacac	10	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:42949965C>G	uc003thw.2	-	2	999	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	C7orf25_uc010kxq.2_Missense_Mutation_p.E179Q|C7orf25_uc003thx.3_Missense_Mutation_p.E237Q|C7orf25_uc010kxr.2_Missense_Mutation_p.E237Q	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	179										skin(1)	1						TTCAGCTTCTCTGCCATGGGG	0.493													0	0	0	0.001368	0	13	88										G	42949965	C	G	42949965	3	3	96	1	0	0	0	0	1	0	0	0	2380	922	32	1	734	1	C7orf25	7	42949965	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10040085	42949965	116188698	409	28885										
GCK	2645	broad.mit.edu	37	chr7	44192943	44192943	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acgtaggtgggcagcatcttCacactggcctcttcatgggt	12	11	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:44192943C>T	uc003tkl.2	-	2	635	c.165G>A	c.(163-165)GTG>GTA	p.V55V	GCK_uc003tkj.1_Silent_p.V54V|GCK_uc003tkk.1_Silent_p.V56V	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	55					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GCAGCATCTTCACACTGGCCT	0.602													0	0	0	0.00361	0	65	131										T	44192943	C	T	44192943	2	4	96	1	0	0	0	0	0	0	0	1	6293	813	29	1		1	GCK	7	44192943	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1242978	44192943	114945720	410	28886										
GCK	2645	broad.mit.edu	37	chr7	44193018	44193018	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atccgtctcatcaccttcttCaggtcctcctcctgcagctg	6	17	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:44193018C>A	uc003tkl.2	-	2	560	c.90G>T	c.(88-90)CTG>CTT	p.L30L	GCK_uc003tkj.1_Silent_p.L29L|GCK_uc003tkk.1_Silent_p.L31L	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	30					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TCACCTTCTTCAGGTCCTCCT	0.632													1	0	9.47799e-51	0.00361	1.21751e-50	83	225										A	44193018	C	A	44193018	2	1	96	1	0	0	0	0	0	0	0	1	6293	813	29	3		3	GCK	7	44193018	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	75	44193018	114945645	411	28887										
YKT6	10652	broad.mit.edu	37	chr7	44250704	44250704	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgaggtgctgggaacacagtCtaaagccttctataaaactg	10	9	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:44250704C>G	uc003tkm.2	+	6	699	c.542C>G	c.(541-543)TCT>TGT	p.S181C	YKT6_uc011kbv.1_Intron	NM_006555	NP_006546	O15498	YKT6_HUMAN	YKT6 v-SNARE protein	181	v-SNARE coiled-coil homology.				ER to Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi|vesicle docking involved in exocytosis|vesicle targeting	cytoplasmic vesicle membrane|cytosol|endoplasmic reticulum|endosome|Golgi membrane|integral to plasma membrane|mitochondrion|SNARE complex	protein-cysteine S-palmitoleyltransferase activity|SNAP receptor activity				0						GGAACACAGTCTAAAGCCTTC	0.502													0	0	0	0.000978	0	12	41										G	44250704	C	G	44250704	3	3	96	1	0	0	0	0	1	0	0	0	17482	913	32	1	564	1	YKT6	7	44250704	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	57686	44250704	114887959	412	28888										
ABCA13	154664	broad.mit.edu	37	chr7	48319282	48319282	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctctggaggaaaggacttCtgtttaacaactctgaatgg	10	8	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:48319282C>T	uc003toq.2	+	18	8516	c.8491C>T	c.(8491-8493)CTG>TTG	p.L2831L	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2831				L -> R (in Ref. 1; AAP13576).	transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAAAGGACTTCTGTTTAACAA	0.348													0	0	0	0.00361	0	48	116										T	48319282	C	T	48319282	2	4	96	1	0	0	0	0	0	0	0	1	31	912	32	1		1	ABCA13	7	48319282	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4068578	48319282	110819381	413	28889										
ABCA13	154664	broad.mit.edu	37	chr7	48559842	48559842	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcctcgcagggcacagtacTtctcctcttgagggttctgc	12	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:48559842T>G	uc003toq.2	+	53	14028	c.14003T>G	c.(14002-14004)CTT>CGT	p.L4668R	ABCA13_uc010kys.1_Missense_Mutation_p.L1743R|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.L398R	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4668	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGCACAGTACTTCTCCTCTTG	0.527													0	0	0	0.000602	0	5	43										G	48559842	T	G	48559842	3	3	96	1	0	0	0	0	1	0	0	0	31	1609	56	5	14042	5	ABCA13	7	48559842	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	240560	48559842	110578821	414	28890										
POM121L12	285877	broad.mit.edu	37	chr7	53104099	53104099	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcctcggcccctggagcctCagtttttgtgatgatgcttg	12	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:53104099C>T	uc003tpz.2	+	1	751	c.735C>T	c.(733-735)CTC>CTT	p.L245L		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	245											0						CCTGGAGCCTCAGTTTTTGTG	0.647													0	0	0	0.004007	0	17	66										T	53104099	C	T	53104099	2	4	96	1	0	0	0	0	0	0	0	1	12241	813	29	1		1	POM121L12	7	53104099	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4544257	53104099	106034564	415	28891										
SEPT14	346288	broad.mit.edu	37	chr7	55873034	55873034	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caactcttcttcttccctctGacattgatcatagaactctt	3	13	6	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:55873034G>A	uc003tqz.2	-	9	1153	c.1036C>T	c.(1036-1038)CAG>TAG	p.Q346*		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	346	Potential.				cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCTTCCCTCTGACATTGATCA	0.303													0	0	0	0.000602	0	5	52										A	55873034	G	A	55873034	4	1	96	1	0	0	0	0	0	1	0	0	14063	1299	45	1	270	1	SEPT14	7	55873034	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2768935	55873034	103265629	416	28892										
AUTS2	26053	broad.mit.edu	37	chr7	70228261	70228261	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acctgtgcaggcccacccctCtgctcagagcctctcccagc	8	20	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:70228261C>G	uc003tvw.3	+	7	1891	c.1148C>G	c.(1147-1149)TCT>TGT	p.S383C	AUTS2_uc003tvx.3_Missense_Mutation_p.S383C|AUTS2_uc011keg.1_5'Flank	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	383	Ser-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCCCACCCCTCTGCTCAGAGC	0.607													0	0	0	0.001368	0	10	106										G	70228261	C	G	70228261	3	3	96	1	0	0	0	0	1	0	0	0	1225	913	32	1	1319	1	AUTS2	7	70228261	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	14355227	70228261	88910402	417	28893										
TYW1B	441250	broad.mit.edu	37	chr7	72081725	72081725	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatttcatattcggggatcaGatccaccagctcgcggacaa	9	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:72081725G>C	uc011kej.1	-	16	1876	c.1717C>G	c.(1717-1719)CTG>GTG	p.L573V	TYW1B_uc011keh.1_Missense_Mutation_p.L411V|TYW1B_uc011kei.1_Missense_Mutation_p.L199V	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	573					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						TCGGGGATCAGATCCACCAGC	0.473													0	0	0	0.00278	0	24	86										C	72081725	G	C	72081725	3	2	96	1	0	0	0	0	1	0	0	0	16816	933	33	1	418	1	TYW1B	7	72081725	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1853464	72081725	87056938	418	28894										
EIF4H	7458	broad.mit.edu	37	chr7	73588773	73588773	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcttcggcggcggcagaggGtgaggcgggcgtgcgcgggc	23	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:73588773G>A	uc003uad.1	+	1	67	c.59_splice	c.e1+1	p.G20_splice	RFC2_uc011kfa.1_Intron|EIF4H_uc011kfg.1_Splice_Site_p.G20_splice|EIF4H_uc010lbm.2_Splice_Site_p.G20_splice|EIF4H_uc003uae.1_Splice_Site_p.G20_splice|EIF4H_uc003uaf.1_Splice_Site	NM_022170	NP_071496	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H						interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity				0						GCGGCAGAGGGTGAGGCGGGC	0.667													0	0	0	0.000978	0	9	55										A	73588773	G	A	73588773	5	1	96	1	0	0	0	0	0	0	1	0	5039	1275	44	2	62	2	EIF4H	7	73588773	Splice_Site	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1507048	73588773	85549890	419	28895										
FGL2	10875	broad.mit.edu	37	chr7	76828608	76828608	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtcaacataattttctatgTtgttcatatttacaagattc	4	6	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:76828608T>G	uc003ugb.2	-	1	543	c.503A>C	c.(502-504)AAC>ACC	p.N168T	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	168					signal transduction	fibrinogen complex	receptor binding			skin(2)	2						ATTTTCTATGTTGTTCATATT	0.388													0	0	0	0.005443	0	28	88										G	76828608	T	G	76828608	3	3	96	1	0	0	0	0	1	0	0	0	5873	1725	60	5	824	5	FGL2	7	76828608	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	3239835	76828608	82310055	420	28896										
PION	54103	broad.mit.edu	37	chr7	76984619	76984619	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtctaagcaagtgttctgcaGaagctgtaataaagacgact	10	7	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:76984619G>A	uc003ugf.2	-	16	1328	c.1249C>T	c.(1249-1251)CTG>TTG	p.L417L	PION_uc003ugg.1_Silent_p.L202L	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	417					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						GTGTTCTGCAGAAGCTGTAAT	0.502													0	0	0	0.00623	0	42	122										A	76984619	G	A	76984619	2	1	96	1	0	0	0	0	0	0	0	1	11934	933	33	1		1	PION	7	76984619	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	156011	76984619	82154044	421	28897										
PTPN12	5782	broad.mit.edu	37	chr7	77256781	77256781	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccactcttcagaacacccctCagttttactaatccacttca	2	16	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:77256781C>T	uc003ugh.2	+	13	1876	c.1785C>T	c.(1783-1785)CTC>CTT	p.L595L	PTPN12_uc011kgp.1_Silent_p.L476L|PTPN12_uc011kgq.1_Silent_p.L465L|PTPN12_uc010lds.2_Silent_p.L327L	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	595						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						GAACACCCCTCAGTTTTACTA	0.403													0	0	0	0.002852	0	44	134										T	77256781	C	T	77256781	2	4	96	1	0	0	0	0	0	0	0	1	12781	813	29	1		1	PTPN12	7	77256781	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	272162	77256781	81881882	422	28898										
CACNA2D1	781	broad.mit.edu	37	chr7	81667445	81667445	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccttcttataatctgtaattCctttggctgtgatattattc	5	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:81667445C>T	uc003uhr.1	-	11	1242	c.986G>A	c.(985-987)GGA>GAA	p.G329E		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	329	Extracellular (Potential).|VWFA.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	atctgtaattcctttggctGT	0.294													0	0	0	0.002096	0	33	87										T	81667445	C	T	81667445	3	4	96	1	0	0	0	0	1	0	0	0	2548	855	30	1	2405	1	CACNA2D1	7	81667445	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4410664	81667445	77471218	423	28899										
ZNF804B	219578	broad.mit.edu	37	chr7	88966042	88966042	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttcagtcctatttcattttCgactctgactccaaccatta	3	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:88966042C>G	uc011khi.1	+	4	4284	c.3746C>G	c.(3745-3747)TCG>TGG	p.S1249W		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1249						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			ATTTCATTTTCGACTCTGACT	0.458										HNSCC(36;0.09)			0	0	0	0.001855	0	14	169										G	88966042	C	G	88966042	3	3	96	1	0	0	0	0	1	0	0	0	18168	893	31	1	3760	1	ZNF804B	7	88966042	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7298597	88966042	70172621	424	28900										
STEAP1	26872	broad.mit.edu	37	chr7	89789150	89789150	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caagaagaactttggaaaatGaagcctaggagaaatttaga	10	4	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:89789150G>A	uc003ujx.2	+	2	248	c.48G>A	c.(46-48)ATG>ATA	p.M16I	STEAP1_uc010lem.2_Missense_Mutation_p.M16I	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	16					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					TTTGGAAAATGAAGCCTAGGA	0.254													0	0	0	0.008291	0	10	105										A	89789150	G	A	89789150	3	1	96	1	0	0	0	0	1	0	0	0	15276	1290	45	1	50	1	STEAP1	7	89789150	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	823108	89789150	69349513	425	28901										
CDK14	5218	broad.mit.edu	37	chr7	90356077	90356077	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cattaactttaagacctcctCcactggcaaagagtcaccta	5	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:90356077C>G	uc003uky.2	+	3	542	c.320C>G	c.(319-321)TCC>TGC	p.S107C	CDK14_uc003ukt.1_Missense_Mutation_p.S61C|CDK14_uc003ukv.1_Missense_Mutation_p.S61C|CDK14_uc003uku.1_Missense_Mutation_p.S61C|CDK14_uc003ukx.1_Intron|CDK14_uc003ukz.1_Missense_Mutation_p.S89C|CDK14_uc010les.1_Missense_Mutation_p.S61C|CDK14_uc011khl.1_Missense_Mutation_p.P10A	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	107					cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						AAGACCTCCTCCACTGGCAAA	0.458													0	0	0	0.00308	0	8	83										G	90356077	C	G	90356077	3	3	96	1	0	0	0	0	1	0	0	0	3130	855	30	1	272	1	CDK14	7	90356077	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	566927	90356077	68782586	426	28902										
CYP51A1	1595	broad.mit.edu	37	chr7	91761093	91761093	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atttggaagacttaccttctCatatgcattttctagaaatt	5	7	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:91761093C>T	uc003ulm.3	-	2	448	c.286G>A	c.(286-288)GAG>AAG	p.E96K	CYP51A1_uc011khn.1_5'UTR|CYP51A1_uc003uln.3_Missense_Mutation_p.E33K|uc003ulo.1_5'Flank	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	90					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CTTACCTTCTCATATGCATTT	0.318													0	0	0	0.008291	0	10	29										T	91761093	C	T	91761093	3	4	96	1	0	0	0	0	1	0	0	0	4195	835	29	1	1279	1	CYP51A1	7	91761093	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1405016	91761093	67377570	427	28903										
CASD1	64921	broad.mit.edu	37	chr7	94166908	94166908	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcttgttttttcactttatCtattatcggatatttaattt	4	5	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:94166908C>G	uc003uni.3	+	9	1195	c.968C>G	c.(967-969)TCT>TGT	p.S323C	CASD1_uc003unh.2_3'UTR|CASD1_uc003unj.3_Missense_Mutation_p.S323C	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	323	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TTCACTTTATCTATTATCGGA	0.358													0	0	0	0.003954	0	27	92										G	94166908	C	G	94166908	3	3	96	1	0	0	0	0	1	0	0	0	2664	913	32	1	1002	1	CASD1	7	94166908	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2405815	94166908	64971755	428	28904										
TRRAP	8295	broad.mit.edu	37	chr7	98548583	98548583	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttgggacctcccaatccaGaaggagataacccagaaagc	9	12	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:98548583G>C	uc003upp.2	+	38	5607	c.5398G>C	c.(5398-5400)GAA>CAA	p.E1800Q	TRRAP_uc011kis.1_Missense_Mutation_p.E1782Q|TRRAP_uc003upr.2_Missense_Mutation_p.E1499Q	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1800					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCCAATCCAGAAGGAGATAA	0.448													0	0	0	0.00361	0	69	238										C	98548583	G	C	98548583	3	2	96	1	0	0	0	0	1	0	0	0	16598	943	33	1	5486	1	TRRAP	7	98548583	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4381675	98548583	60590080	429	28905										
SMURF1	57154	broad.mit.edu	37	chr7	98649052	98649052	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtaaacttggccctggactGttgttctttgttctacacaa	8	9	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:98649052G>C	uc003upu.1	-	8	1054	c.734C>G	c.(733-735)ACA>AGA	p.T245R	SMURF1_uc003upv.1_Missense_Mutation_p.T245R|SMURF1_uc003upt.2_Missense_Mutation_p.T245R	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	245	WW 1.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GCCCTGGACTGTTGTTCTTTG	0.473													0	0	0	0.00361	0	48	96										C	98649052	G	C	98649052	3	2	96	1	0	0	0	0	1	0	0	0	14819	1377	48	4	1587	4	SMURF1	7	98649052	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	100469	98649052	60489611	430	28906										
C7orf51	222950	broad.mit.edu	37	chr7	100087045	100087045	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccccctgcctatgagagcctCaaggctgggggggtgctgaa	15	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100087045C>G	uc003uvd.1	+	4	1860	c.1701C>G	c.(1699-1701)CTC>CTG	p.L567L	C7orf51_uc003uve.1_Silent_p.L349L	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	567										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATGAGAGCCTCAAGGCTGGGG	0.647													0	0	0	0.006122	0	18	42										G	100087045	C	G	100087045	2	3	96	1	0	0	0	0	0	0	0	1	2400	813	29	1		1	C7orf51	7	100087045	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1437993	100087045	59051618	431	28907										
GIGYF1	64599	broad.mit.edu	37	chr7	100283618	100283618	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcctcaggcccttcctcctCtagcccttcggaaggttcct	8	17	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100283618C>G	uc003uwg.1	-	9	2042	c.1033G>C	c.(1033-1035)GAG>CAG	p.E345Q		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	345										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCTTCCTCCTCTAGCCCTTCG	0.687													0	0	0	0.001855	0	12	32										G	100283618	C	G	100283618	3	3	96	1	0	0	0	0	1	0	0	0	6377	922	32	1	2138	1	GIGYF1	7	100283618	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	196573	100283618	58855045	432	28908										
GIGYF1	64599	broad.mit.edu	37	chr7	100283898	100283898	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagcccatccttgtcctcctCaaagccttcaggcgctcggc	9	17	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100283898C>G	uc003uwg.1	-	8	1862	c.853G>C	c.(853-855)GAG>CAG	p.E285Q		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	285										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTGTCCTCCTCAAAGCCTTCA	0.607													0	0	0	0.001786	0	27	101										G	100283898	C	G	100283898	3	3	96	1	0	0	0	0	1	0	0	0	6377	835	29	1	2322	1	GIGYF1	7	100283898	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	280	100283898	58854765	433	28909										
GIGYF1	64599	broad.mit.edu	37	chr7	100284421	100284421	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccttccttgggccagcccctCcctcctcaaagccacatcgt	6	20	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:100284421C>G	uc003uwg.1	-	7	1554	c.545G>C	c.(544-546)GGA>GCA	p.G182A		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	182										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GCCAGCCCCTCCCTCCTCAAA	0.557													0	0	0	0.007413	0	17	51										G	100284421	C	G	100284421	3	3	96	1	0	0	0	0	1	0	0	0	6377	855	30	1	2634	1	GIGYF1	7	100284421	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	523	100284421	58854242	434	28910										
PRKAR2B	5577	broad.mit.edu	37	chr7	106797459	106797459	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgattcttttttcattgtaGaatctggagaagtgaaaatt	8	4	3	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:106797459G>C	uc003vdx.2	+	9	1124	c.949G>C	c.(949-951)GAA>CAA	p.E317Q		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	317	cAMP 2.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						TTTCATTGTAGAATCTGGAGA	0.343													0	0	0	0.00361	0	44	136										C	106797459	G	C	106797459	3	2	96	1	0	0	0	0	1	0	0	0	12506	943	33	1	983	1	PRKAR2B	7	106797459	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6513038	106797459	52341204	435	28911										
GPR22	2845	broad.mit.edu	37	chr7	107115258	107115258	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agattttcaacagggcagaaGaagaaagcaagaaagaaaaa	10	4	1	6			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:107115258G>A	uc003vef.2	+	3	2099	c.753G>A	c.(751-753)AAG>AAA	p.K251K	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	251	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						CAGGGCAGAAGAAGAAAGCAA	0.363													0	0	0	0.004482	0	8	23										A	107115258	G	A	107115258	2	1	96	1	0	0	0	0	0	0	0	1	6682	933	33	1		1	GPR22	7	107115258	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	317799	107115258	52023405	436	28912										
SLC26A3	1811	broad.mit.edu	37	chr7	107430026	107430026	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcaactgaaaaatgaatttGagttgggaaaccaaaacatg	9	5	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:107430026G>C	uc003ver.2	-	6	889	c.678C>G	c.(676-678)CTC>CTG	p.L226L	SLC26A3_uc003ves.2_Silent_p.L191L	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	226					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						AAATGAATTTGAGTTGGGAAA	0.388													0	0	0	0.000248	0	3	34										C	107430026	G	C	107430026	2	2	96	1	0	0	0	0	0	0	0	1	14518	1277	45	1		1	SLC26A3	7	107430026	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	314768	107430026	51708637	437	28913										
FOXP2	93986	broad.mit.edu	37	chr7	114282626	114282626	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagcatcaccaccaataactCatcattccatagtgaatgga	5	11	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:114282626C>T	uc003vhb.2	+	7	1311	c.937C>T	c.(937-939)CAT>TAT	p.H313Y	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.H338Y|FOXP2_uc003vha.2_Missense_Mutation_p.H221Y|FOXP2_uc011kmu.1_Missense_Mutation_p.H330Y|FOXP2_uc011kmv.1_Missense_Mutation_p.H312Y|FOXP2_uc010ljz.1_Missense_Mutation_p.H221Y|FOXP2_uc003vgx.2_Missense_Mutation_p.H313Y|FOXP2_uc003vhd.2_Missense_Mutation_p.H313Y|FOXP2_uc003vhc.2_Missense_Mutation_p.H338Y	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	313					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						ACCAATAACTCATCATTCCAT	0.393													0	0	0	0.002299	0	20	61										T	114282626	C	T	114282626	3	4	96	1	0	0	0	0	1	0	0	0	6027	826	29	1	1093	1	FOXP2	7	114282626	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6852600	114282626	44856037	438	28914										
PTPRZ1	5803	broad.mit.edu	37	chr7	121652699	121652699	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttgcttaaaactgttcttcCagctgtgcccagtgatccaa	7	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:121652699C>T	uc003vjy.2	+	12	3994	c.3599C>T	c.(3598-3600)CCA>CTA	p.P1200L	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1200	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACTGTTCTTCCAGCTGTGCCC	0.378													0	0	0	0.00361	0	50	161										T	121652699	C	T	121652699	3	4	96	1	0	0	0	0	1	0	0	0	12814	594	21	2	3645	2	PTPRZ1	7	121652699	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7370073	121652699	37485964	439	28915										
FEZF1	389549	broad.mit.edu	37	chr7	121943827	121943827	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatgctgcagctgagcctggGacaggtctttgaaagctact	12	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:121943827G>C	uc003vkd.2	-	1	739	c.665C>G	c.(664-666)TCC>TGC	p.S222C	FEZF1_uc003vkc.2_Missense_Mutation_p.S172C|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	222					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						CTGAGCCTGGGACAGGTCTTT	0.512													0	0	0	0.005443	0	27	87										C	121943827	G	C	121943827	3	2	96	1	0	0	0	0	1	0	0	0	5825	1174	41	1	778	1	FEZF1	7	121943827	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	291128	121943827	37194836	440	28916										
GPR37	2861	broad.mit.edu	37	chr7	124386968	124386968	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttcatctgactctctagttGaatctgccgtttattccctc	6	12	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:124386968G>T	uc003vli.2	-	2	2104	c.1453C>A	c.(1453-1455)CAA>AAA	p.Q485K		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	485	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTCTCTAGTTGAATCTGCCGT	0.433													1	0	2.48779e-11	0.005443	3.09898e-11	26	102										T	124386968	G	T	124386968	3	4	96	1	0	0	0	0	1	0	0	0	6691	1299	45	3	392	3	GPR37	7	124386968	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2443141	124386968	34751695	441	28917										
METTL2B	55798	broad.mit.edu	37	chr7	128119545	128119545	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgatgagtttcctggatcctCagccacctaccgaatactgg	9	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:128119545C>T	uc003vnf.2	+	3	573	c.536C>T	c.(535-537)TCA>TTA	p.S179L	METTL2B_uc003vng.2_Missense_Mutation_p.S114L|METTL2B_uc011kop.1_Missense_Mutation_p.S43L	NM_018396	NP_060866	Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	179							methyltransferase activity			skin(1)	1						CCTGGATCCTCAGCCACCTAC	0.428													0	0	0	0.00278	0	22	81										T	128119545	C	T	128119545	3	4	96	1	0	0	0	0	1	0	0	0	9500	838	29	1	546	1	METTL2B	7	128119545	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3732577	128119545	31019118	442	28918										
ATP6V0A4	50617	broad.mit.edu	37	chr7	138447178	138447178	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catcagctaaattggtttccGtctgaaagtcaaagcactat	7	9	3	1	rs144802156	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:138447178G>A	uc003vuf.2	-	6	657	c.419C>T	c.(418-420)ACG>ATG	p.T140M	ATP6V0A4_uc003vug.2_Missense_Mutation_p.T140M|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.T140M	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	140	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						ATTGGTTTCCGTCTGAAAGTC	0.393													0	0	0	0.003163	0	15	43										A	138447178	G	A	138447178	3	1	96	1	0	0	0	0	1	0	0	0	1170	1159	40	2	2167	2	ATP6V0A4	7	138447178	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10327633	138447178	20691485	443	28919										
TRPV6	55503	broad.mit.edu	37	chr7	142571845	142571845	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttacctgaagcaaagcccagGatgaccacagccatcagcca	8	14	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:142571845G>A	uc003wbx.1	-	12	1719	c.1503C>T	c.(1501-1503)ATC>ATT	p.I501I	TRPV6_uc003wbw.1_Silent_p.I287I|TRPV6_uc010lou.1_Silent_p.I372I	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	501	Helical; (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CAAAGCCCAGGATGACCACAG	0.537													0	0	0	0.004482	0	6	24										A	142571845	G	A	142571845	2	1	96	1	0	0	0	0	0	0	0	1	16597	1164	41	1		1	TRPV6	7	142571845	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4124667	142571845	16566818	444	28920										
C7orf29	113763	broad.mit.edu	37	chr7	150028006	150028006	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agggagaagggcttgctggaGagcatggggctgctggcctc	19	8	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:150028006G>A	uc003wgy.2	+	1	1069	c.513G>A	c.(511-513)GAG>GAA	p.E171E	LRRC61_uc003wgv.2_Intron|LRRC61_uc003wgx.2_Intron|LRRC61_uc003wgw.2_Intron	NM_138434	NP_612443	Q96FA7	CG029_HUMAN	hypothetical protein LOC113763	171										ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.011)			GCTTGCTGGAGAGCATGGGGC	0.632													0	0	0	0.000602	0	5	27										A	150028006	G	A	150028006	2	1	96	1	0	0	0	0	0	0	0	1	2385	933	33	1		1	C7orf29	7	150028006	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7456161	150028006	9110657	445	28921										
ABCB8	11194	broad.mit.edu	37	chr7	150732745	150732745	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acacgcctcacgctgctgctGatggtggccacaccagccct	10	17	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:150732745G>A	uc003wil.3	+	7	987	c.894G>A	c.(892-894)CTG>CTA	p.L298L	ABCB8_uc003wii.2_Silent_p.L318L|ABCB8_uc003wij.3_Silent_p.L281L|ABCB8_uc010lpw.1_Silent_p.L100L|ABCB8_uc010lpx.2_Silent_p.L281L|ABCB8_uc011kvd.1_Silent_p.L193L|ABCB8_uc003wim.3_Silent_p.L76L|ABCB8_uc003wik.3_Silent_p.L281L	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	298	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCTGCTGCTGATGGTGGCCA	0.652													0	0	0	0.002836	0	35	76										A	150732745	G	A	150732745	2	1	96	1	0	0	0	0	0	0	0	1	47	1277	45	1		1	ABCB8	7	150732745	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	704739	150732745	8405918	446	28922										
GBX1	2636	broad.mit.edu	37	chr7	150864185	150864185	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccgggccggcagcagctcatCagcttccagcccaccctctg	10	19	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:150864185C>T	uc011kvg.1	-	1	683	c.451G>A	c.(451-453)GAT>AAT	p.D151N		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	151	Pro-rich.					nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAGCTCATCAGCTTCCAGC	0.542													0	0	0	0.00632	0	26	75										T	150864185	C	T	150864185	3	4	96	1	0	0	0	0	1	0	0	0	6280	826	29	1	647	1	GBX1	7	150864185	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	131440	150864185	8274478	447	28923										
PTPRN2	5799	broad.mit.edu	37	chr7	157387990	157387990	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggcgatgtacgcggggttCctcgggtcgtgatccatctg	16	10	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:157387990C>A	uc003wno.2	-	17	2557	c.2436G>T	c.(2434-2436)AGG>AGT	p.R812S	PTPRN2_uc003wnp.2_Missense_Mutation_p.R795S|PTPRN2_uc003wnq.2_Missense_Mutation_p.R783S|PTPRN2_uc003wnr.2_Missense_Mutation_p.R774S|PTPRN2_uc011kwa.1_Missense_Mutation_p.R835S	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	812	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACGCGGGGTTCCTCGGGTCGT	0.532													1	0	4.7796e-09	0.004656	5.85258e-09	24	72										A	157387990	C	A	157387990	3	1	96	1	0	0	0	0	1	0	0	0	12808	854	30	3	639	3	PTPRN2	7	157387990	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6523805	157387990	1750673	448	28924										
NCAPG2	54892	broad.mit.edu	37	chr7	158437065	158437065	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgcaacctccctcacttttGagcttttatgtttacctggg	7	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr7:158437065G>C	uc003wnv.1	-	27	3441	c.3296C>G	c.(3295-3297)TCA>TGA	p.S1099*	NCAPG2_uc010lqu.1_Nonsense_Mutation_p.S844*|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Nonsense_Mutation_p.S1099*|NCAPG2_uc011kwe.1_Nonsense_Mutation_p.S1099*|NCAPG2_uc011kwc.1_Nonsense_Mutation_p.S553*|NCAPG2_uc011kwd.1_Nonsense_Mutation_p.S542*	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	1099					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		CCTCACTTTTGAGCTTTTATG	0.358													0	0	0	0.002299	0	21	145										C	158437065	G	C	158437065	4	2	96	1	0	0	0	0	0	1	0	0	10208	1294	45	1	143	1	NCAPG2	7	158437065	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1049075	158437065	701598	449	28925										
FGL1	2267	broad.mit.edu	37	chr8	17739572	17739572	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcctttatcaaggaactgGacttcattctcctgcaaaag	6	11	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:17739572G>C	uc003wxx.2	-	4	504	c.180C>G	c.(178-180)GTC>GTG	p.V60V	FGL1_uc003wxy.2_Silent_p.V60V|FGL1_uc003wxz.2_Silent_p.V60V|FGL1_uc003wya.2_Silent_p.V60V|FGL1_uc003wyb.2_Silent_p.V60V|FGL1_uc003wyc.2_Silent_p.V60V|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Silent_p.V110V|FGL1_uc003wyf.2_Silent_p.V30V	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	60	Potential.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAAGGAACTGGACTTCATTCT	0.478													0	0	0	0.002836	0	36	83										C	17739572	G	C	17739572	2	2	96	1	0	0	0	0	0	0	0	1	5872	1161	41	1		1	FGL1	8	17739572	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		17739572	128624450	450	28926										
LGI3	203190	broad.mit.edu	37	chr8	22011497	22011497	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttacaagtcattcaggatgtCcaggggccggaagatgtctc	12	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:22011497C>G	uc003xav.2	-	5	767	c.478G>C	c.(478-480)GAC>CAC	p.D160H	LGI3_uc010ltu.2_Missense_Mutation_p.D136H	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	160					exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		TTCAGGATGTCCAGGGGCCGG	0.572													0	0	0	0.003163	0	12	81										G	22011497	C	G	22011497	3	3	96	1	0	0	0	0	1	0	0	0	8753	855	30	1	1184	1	LGI3	8	22011497	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4271925	22011497	124352525	451	28927										
C8orf58	541565	broad.mit.edu	37	chr8	22459311	22459311	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgtgcctggtgctggagcaGatggcaaggctccagcagct	15	11	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:22459311G>C	uc003xce.2	+	3	715	c.603G>C	c.(601-603)CAG>CAC	p.Q201H	C8orf58_uc011kzl.1_Missense_Mutation_p.Q201H|C8orf58_uc003xcf.2_Missense_Mutation_p.Q201H|KIAA1967_uc003xch.2_5'Flank	NM_001013842	NP_001013864	Q8NAV2	CH058_HUMAN	hypothetical protein LOC541565	201										skin(1)	1		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TGCTGGAGCAGATGGCAAGGC	0.662													0	0	0	0.002222	0	41	98										C	22459311	G	C	22459311	3	2	96	1	0	0	0	0	1	0	0	0	2433	933	33	1	613	1	C8orf58	8	22459311	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	447814	22459311	123904711	452	28928										
CDCA2	157313	broad.mit.edu	37	chr8	25343351	25343351	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcaatctctgagaccctttCaggtagtaacttgtttatct	6	9	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:25343351C>T	uc003xep.1	+	11	1921	c.1442C>T	c.(1441-1443)TCA>TTA	p.S481L	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Missense_Mutation_p.S481L|CDCA2_uc003xeq.1_Missense_Mutation_p.S466L|CDCA2_uc003xer.1_Missense_Mutation_p.S144L	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	481					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		GAGACCCTTTCAGGTAGTAAC	0.279													0	0	0	0.008291	0	11	30										T	25343351	C	T	25343351	3	4	96	1	0	0	0	0	1	0	0	0	3086	838	29	1	1480	1	CDCA2	8	25343351	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2884040	25343351	121020671	453	28929										
RAB11FIP1	80223	broad.mit.edu	37	chr8	37728859	37728859	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctggatgtgtctccgagggtGagacccaggcctggaggagt	17	9	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:37728859G>T	uc003xkm.1	-	4	3505	c.3461C>A	c.(3460-3462)TCA>TAA	p.S1154*	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Nonsense_Mutation_p.S483*|RAB11FIP1_uc003xko.1_Nonsense_Mutation_p.S483*|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	1154					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTCCGAGGGTGAGACCCAGGC	0.542											OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.62699e-14	0.003163	3.28945e-14	15	199										T	37728859	G	T	37728859	4	4	96	1	0	0	0	0	0	1	0	0	12893	1294	45	3	402	3	RAB11FIP1	8	37728859	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	12385508	37728859	108635163	454	28930										
IKBKB	3551	broad.mit.edu	37	chr8	42179979	42179979	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggctgcaggagaagcggcaGaaggagctctggaatctcct	15	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:42179979G>A	uc003xow.1	+	19	2130	c.1953G>A	c.(1951-1953)CAG>CAA	p.Q651Q	IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Silent_p.Q428Q|IKBKB_uc003xox.1_Silent_p.Q372Q|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.Q649Q|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Silent_p.Q592Q	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	651					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AGAAGCGGCAGAAGGAGCTCT	0.567													0	0	0	0.006122	0	18	121										A	42179979	G	A	42179979	2	1	96	1	0	0	0	0	0	0	0	1	7611	933	33	1		1	IKBKB	8	42179979	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4451120	42179979	104184043	455	28931										
POTEA	340441	broad.mit.edu	37	chr8	43197332	43197332	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtattatttatcttacaggtCaaaagccaaatacattcagt	5	7	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:43197332C>G	uc003xpz.1	+	11	1264	c.1221C>G	c.(1219-1221)GTC>GTG	p.V407V	POTEA_uc003xqa.1_Silent_p.V361V	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	407										ovary(1)	1						TCTTACAGGTCAAAAGCCAAA	0.318													0	0	0	0.001168	0	4	44										G	43197332	C	G	43197332	2	3	96	1	0	0	0	0	0	0	0	1	12261	813	29	1		1	POTEA	8	43197332	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1017353	43197332	103166690	456	28932										
PRKDC	5591	broad.mit.edu	37	chr8	48711931	48711931	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagaggtgctggaatgctctCtggtacagacccgcgatcac	13	11	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:48711931C>T	uc003xqi.2	-	73	10194	c.10137G>A	c.(10135-10137)CAG>CAA	p.Q3379Q	PRKDC_uc003xqj.2_Silent_p.Q3379Q|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3379	FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGAATGCTCTCTGGTACAGAC	0.552								NHEJ					0	0	0	0.00361	0	59	93										T	48711931	C	T	48711931	2	4	96	1	0	0	0	0	0	0	0	1	12521	912	32	1		1	PRKDC	8	48711931	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5514599	48711931	97652091	457	28933										
PRKDC	5591	broad.mit.edu	37	chr8	48801695	48801695	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagccataacctggacgtctCcgatgttgaaacctatgctt	9	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:48801695C>A	uc003xqi.2	-	34	4217	c.4160G>T	c.(4159-4161)GGA>GTA	p.G1387V	PRKDC_uc003xqj.2_Missense_Mutation_p.G1387V|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1387					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTGGACGTCTCCGATGTTGAA	0.463								NHEJ					1	0	2.4624e-09	0.008871	3.02032e-09	18	54										A	48801695	C	A	48801695	3	1	96	1	0	0	0	0	1	0	0	0	12521	855	30	3	8442	3	PRKDC	8	48801695	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	89764	48801695	97562327	458	28934										
MYBL1	4603	broad.mit.edu	37	chr8	67507965	67507965	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttcttcgcatagtagaattCcaatgatttttgatagaatt	6	5	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:67507965C>T	uc003xwj.2	-	6	947	c.540G>A	c.(538-540)TGG>TGA	p.W180*	MYBL1_uc003xwl.2_Nonsense_Mutation_p.W180*|MYBL1_uc003xwk.2_Nonsense_Mutation_p.W180*	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	180	HTH myb-type 3.|H-T-H motif (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			TAGTAGAATTCCAATGATTTT	0.333													0	0	0	0.000248	0	4	6										T	67507965	C	T	67507965	4	4	96	1	0	0	0	0	0	1	0	0	10009	856	30	1	1762	1	MYBL1	8	67507965	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	18706270	67507965	78856057	459	28935										
TRPA1	8989	broad.mit.edu	37	chr8	72975076	72975076	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccattgtccaggcacattttGatcatttccaagtcaccatt	5	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:72975076G>C	uc003xza.2	-	6	940	c.765C>G	c.(763-765)ATC>ATG	p.I255M		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	255	ANK 6.|Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GGCACATTTTGATCATTTCCA	0.388													0	0	0	0.001855	0	13	71										C	72975076	G	C	72975076	3	2	96	1	0	0	0	0	1	0	0	0	16574	1280	45	1	2682	1	TRPA1	8	72975076	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5467111	72975076	73388946	460	28936										
LRRCC1	85444	broad.mit.edu	37	chr8	86022358	86022358	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttttttttttaggacttgaaGaactaattaatctgactaga	6	4	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:86022358G>A	uc003ycw.2	+	3	473	c.319G>A	c.(319-321)GAA>AAA	p.E107K	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_5'UTR|LRRCC1_uc003ycx.2_Missense_Mutation_p.E14K|LRRCC1_uc003ycy.2_Missense_Mutation_p.E87K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	107	LRR 3.				cell division|mitosis	centriole|nucleus					0						aGGACTTGAAGAACTAATTAA	0.229													0	0	0	0.008291	0	9	52										A	86022358	G	A	86022358	3	1	96	1	0	0	0	0	1	0	0	0	9026	943	33	1	329	1	LRRCC1	8	86022358	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	13047282	86022358	60341664	461	28937										
RIPK2	8767	broad.mit.edu	37	chr8	90798902	90798902	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgccagctcctcaagacaatGattttttatctagtatgtag	7	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:90798902G>A	uc003yee.2	+	9	1425	c.1111G>A	c.(1111-1113)GAT>AAT	p.D371N	RIPK2_uc003yef.2_Missense_Mutation_p.D234N	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	371					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			TCAAGACAATGATTTTTTATC	0.338													0	0	0	0.001855	0	13	124										A	90798902	G	A	90798902	3	1	96	1	0	0	0	0	1	0	0	0	13381	1290	45	1	1145	1	RIPK2	8	90798902	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4776544	90798902	55565120	462	28938										
PGCP	10404	broad.mit.edu	37	chr8	98155285	98155285	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacttatacaagtatttcttCttccatcactcccacggaga	5	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:98155285C>T	uc003yhw.2	+	8	1459	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F		NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	431					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					AGTATTTCTTCTTCCATCACT	0.433													0	0	0	0.004007	0	16	37										T	98155285	C	T	98155285	2	4	96	1	0	0	0	0	0	0	0	1	11786	912	32	1		1	PGCP	8	98155285	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7356383	98155285	48208737	463	28939										
MTDH	92140	broad.mit.edu	37	chr8	98712020	98712020	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttctcagtctaccacttctGattatcagtgggatgttagc	8	9	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:98712020G>C	uc003yhz.2	+	7	1415	c.1087G>C	c.(1087-1089)GAT>CAT	p.D363H	MTDH_uc010mbf.2_Intron	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	363	Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TACCACTTCTGATTATCAGTG	0.333													0	0	0	0.008361	0	27	183										C	98712020	G	C	98712020	3	2	96	1	0	0	0	0	1	0	0	0	9917	1290	45	1	1113	1	MTDH	8	98712020	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	556735	98712020	47652002	464	28940										
NIPAL2	79815	broad.mit.edu	37	chr8	99234791	99234791	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttatatttggagcaaagttCaccagtaaatatgttcctgc	8	7	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:99234791C>A	uc003yil.1	-	5	730	c.474G>T	c.(472-474)GTG>GTT	p.V158V	NIPAL2_uc011lgw.1_5'UTR|NIPAL2_uc003yim.1_Silent_p.V158V	NM_024759	NP_079035	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	158	Helical; (Potential).					integral to membrane					0						GAGCAAAGTTCACCAGTAAAT	0.363													1	0	3.52763e-06	0.00499	4.258e-06	17	130										A	99234791	C	A	99234791	2	1	96	1	0	0	0	0	0	0	0	1	10425	813	29	3		3	NIPAL2	8	99234791	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	522771	99234791	47129231	465	28941										
FBXO43	286151	broad.mit.edu	37	chr8	101153700	101153700	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cactaaagtcatgtgtgataGagtctttaaaattattgccc	7	7	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:101153700G>C	uc003yjd.2	-	2	1495	c.782C>G	c.(781-783)TCT>TGT	p.S261C	FBXO43_uc003yje.2_Missense_Mutation_p.S227C|FBXO43_uc010mbp.1_Missense_Mutation_p.S261C	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	261					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			ATGTGTGATAGAGTCTTTAAA	0.378													0	0	0	0.002299	0	23	46										C	101153700	G	C	101153700	3	2	96	1	0	0	0	0	1	0	0	0	5752	942	33	1	1360	1	FBXO43	8	101153700	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1918909	101153700	45210322	466	28942										
ASAP1	50807	broad.mit.edu	37	chr8	131200403	131200403	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aacaaagaatccaaggtgaaGatcacattgtggctcaaacc	8	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:131200403G>A	uc003yta.1	-	5	460	c.432C>T	c.(430-432)ATC>ATT	p.I144I	ASAP1_uc011liw.1_Silent_p.I137I	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	144					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						CCAAGGTGAAGATCACATTGT	0.323													0	0	0	0.00361	0	44	265										A	131200403	G	A	131200403	2	1	96	1	0	0	0	0	0	0	0	1	1010	932	33	1		1	ASAP1	8	131200403	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	30046703	131200403	15163619	467	28943										
PTK2	5747	broad.mit.edu	37	chr8	141754781	141754781	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcttttgctctctagatatGcaagagctgtactaagctga	8	8	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:141754781G>A	uc003yvu.2	-	19	1834	c.1604C>T	c.(1603-1605)GCA>GTA	p.A535V	PTK2_uc003yvo.2_Missense_Mutation_p.A163V|PTK2_uc011ljq.1_Missense_Mutation_p.A230V|PTK2_uc003yvp.2_Missense_Mutation_p.A203V|PTK2_uc003yvq.2_Missense_Mutation_p.A61V|PTK2_uc003yvr.2_Missense_Mutation_p.A475V|PTK2_uc003yvs.2_Missense_Mutation_p.A535V|PTK2_uc003yvt.2_Missense_Mutation_p.A557V|PTK2_uc003yvv.2_Missense_Mutation_p.A435V|PTK2_uc011ljr.1_Missense_Mutation_p.A535V	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	535	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CTCTAGATATGCAAGAGCTGT	0.383													0	0	0	0.003271	0	30	110										A	141754781	G	A	141754781	3	1	96	1	0	0	0	0	1	0	0	0	12762	1319	46	2	1610	2	PTK2	8	141754781	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10554378	141754781	4609241	468	28944										
CYP11B2	1585	broad.mit.edu	37	chr8	143999073	143999073	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catctccaggtgcaggtgctCataaccctgctccctccaga	8	16	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:143999073C>T	uc003yxk.1	-	1	187	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	62					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TGCAGGTGCTCATAACCCTGC	0.637									Familial_Hyperaldosteronism_type_I				0	0	0	0.001168	0	6	55										T	143999073	C	T	143999073	3	4	96	1	0	0	0	0	1	0	0	0	4146	835	29	1	1363	1	CYP11B2	8	143999073	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2244292	143999073	2364949	469	28945										
TOP1MT	116447	broad.mit.edu	37	chr8	144411579	144411579	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctttgttgtgtattcatgatCtaacatcctcccataaaaag	5	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:144411579C>T	uc003yxz.2	-	3	320	c.301G>A	c.(301-303)GAT>AAT	p.D101N	TOP1MT_uc011lkd.1_Missense_Mutation_p.D3N|TOP1MT_uc011lke.1_Missense_Mutation_p.D3N|TOP1MT_uc010mfb.2_Missense_Mutation_p.D3N|TOP1MT_uc010mfd.1_5'UTR	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	101					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	TATTCATGATCTAACATCCTC	0.547													0	0	0	0.003163	0	15	121										T	144411579	C	T	144411579	3	4	96	1	0	0	0	0	1	0	0	0	16361	913	32	1	1552	1	TOP1MT	8	144411579	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	412506	144411579	1952443	470	28946										
RHPN1	114822	broad.mit.edu	37	chr8	144463988	144463988	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccccacaggcggctggcctGaaggagggcgactacattgt	14	12	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:144463988G>A	uc003yyb.2	+	14	1780	c.1647G>A	c.(1645-1647)CTG>CTA	p.L549L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	574	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CGGCTGGCCTGAAGGAGGGCG	0.677													0	0	0	0.00308	0	8	15										A	144463988	G	A	144463988	2	1	96	1	0	0	0	0	0	0	0	1	13350	1277	45	1		1	RHPN1	8	144463988	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	52409	144463988	1900034	471	28947										
ZNF16	7564	broad.mit.edu	37	chr8	146156262	146156262	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggaccgaacgctgactgaaGgctttcccacactcactgca	9	14	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr8:146156262G>A	uc003zet.2	-	4	2098	c.1911C>T	c.(1909-1911)GCC>GCT	p.A637A	ZNF16_uc003zeu.2_Silent_p.A637A	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	637	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GCTGACTGAAGGCTTTCCCAC	0.542													0	0	0	0.005443	0	28	77										A	146156262	G	A	146156262	2	1	96	1	0	0	0	0	0	0	0	1	17735	987	35	2		2	ZNF16	8	146156262	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1692274	146156262	207760	472	28948										
MPDZ	8777	broad.mit.edu	37	chr9	13224526	13224526	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtaggaatcacagctgggctGagatgaggaacgtgggcata	16	6	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:13224526G>A	uc010mia.1	-	3	297	c.240C>T	c.(238-240)CTC>CTT	p.L80L	MPDZ_uc010mhy.2_Silent_p.L80L|MPDZ_uc010mhz.2_Silent_p.L80L|MPDZ_uc011lmn.1_Silent_p.L80L|MPDZ_uc003zlb.3_Silent_p.L80L	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	80					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CAGCTGGGCTGAGATGAGGAA	0.378													0	0	0	0.004656	0	27	33										A	13224526	G	A	13224526	2	1	96	1	0	0	0	0	0	0	0	1	9722	1277	45	1		1	MPDZ	9	13224526	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		13224526	127988905	473	28949										
FREM1	158326	broad.mit.edu	37	chr9	14805073	14805073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtacaccgtgaactggtcggCagttggttctatcctcagat	11	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:14805073C>T	uc003zlm.2	-	19	3942	c.3352G>A	c.(3352-3354)GCC>ACC	p.A1118T	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1118	CSPG 7.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		AACTGGTCGGCAGTTGGTTCT	0.438													0	0	0	0.00361	0	50	60										T	14805073	C	T	14805073	3	4	96	1	0	0	0	0	1	0	0	0	6044	710	25	2	3313	2	FREM1	9	14805073	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1580547	14805073	126408358	474	28950										
FREM1	158326	broad.mit.edu	37	chr9	14805089	14805089	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcggcagttggttctatcctCagatgcctggactgcacata	10	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:14805089C>T	uc003zlm.2	-	19	3926	c.3336G>A	c.(3334-3336)CTG>CTA	p.L1112L	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1112	CSPG 7.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GTTCTATCCTCAGATGCCTGG	0.408													0	0	0	0.00361	0	52	64										T	14805089	C	T	14805089	2	4	96	1	0	0	0	0	0	0	0	1	6044	813	29	1		1	FREM1	9	14805089	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	16	14805089	126408342	475	28951										
RPS6	6194	broad.mit.edu	37	chr9	19376375	19376375	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaatttgttcctggcgcttCtccttagcctcctaaacaaa	6	13	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:19376375C>G	uc003znv.1	-	6	708	c.666G>C	c.(664-666)GAG>GAC	p.E222D	RPS6_uc003znu.1_Missense_Mutation_p.E191D	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	222					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		CCTGGCGCTTCTCCTTAGCCT	0.448													0	0	0	0.002096	0	32	52										G	19376375	C	G	19376375	3	3	96	1	0	0	0	0	1	0	0	0	13649	912	32	1	87	1	RPS6	9	19376375	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4571286	19376375	121837056	476	28952										
CDKN2A	1029	broad.mit.edu	37	chr9	21971003	21971003	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcgcgatggcccagctcctCagccaggtccacgggcagac	12	16	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:21971003C>T	uc003zpk.2	-	2	567	c.355G>A	c.(355-357)GAG>AAG	p.E119K	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Silent_p.*174*	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	119	ANK 4.		E -> Q (in a biliary tract tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.E119Q(2)|p.E119*(2)|p.A118fs*10(1)|p.A118fs*27(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCCAGCTCCTCAGCCAGGTCC	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.001855	0	14	21										T	21971003	C	T	21971003	3	4	96	1	0	0	0	0	1	0	0	0	3161	838	29	1	123	1	CDKN2A	9	21971003	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2594628	21971003	119242428	477	28953										
CDKN2A	1029	broad.mit.edu	37	chr9	21971036	21971036	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggcagacggccccaggcatCgcgcacgtccagccgcgccc	14	19	0	1	rs121913381		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:21971036C>T	uc003zpk.2	-	2	534	c.322G>A	c.(322-324)GAT>AAT	p.D108N	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.R163Q	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	108			D -> Y (in a head and neck tumor).|D -> H (in a bladder tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.D108Y(14)|p.?(13)|p.D108H(9)|p.D108N(5)|p.H83fs*2(2)|p.D105fs*8(1)|p.A68fs*3(1)|p.R107fs*33(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCCCAGGCATCGCGCACGTCC	0.741		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.000978	0	10	17										T	21971036	C	T	21971036	3	4	96	1	0	0	0	0	1	0	0	0	3161	884	31	1	156	1	CDKN2A	9	21971036	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	33	21971036	119242395	478	28954										
PLAA	9373	broad.mit.edu	37	chr9	26905860	26905860	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgggacatcagtgattccctCtgggacatcatgagtttttg	11	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:26905860C>G	uc003zqd.2	-	14	2462	c.2037G>C	c.(2035-2037)CAG>CAC	p.Q679H		NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	679	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		GTGATTCCCTCTGGGACATCA	0.443													0	0	0	0.001523	0	21	37										G	26905860	C	G	26905860	3	3	96	1	0	0	0	0	1	0	0	0	12011	912	32	1	354	1	PLAA	9	26905860	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4934824	26905860	114307571	479	28955										
NOL6	65083	broad.mit.edu	37	chr9	33467733	33467733	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agccagcaggttcagccgagCccccaggccctgctccagga	12	17	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:33467733C>T	uc003zsz.2	-	12	1659	c.1558G>A	c.(1558-1560)GCT>ACT	p.A520T	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Missense_Mutation_p.A520T|NOL6_uc010mjv.2_Missense_Mutation_p.A517T|NOL6_uc011lob.1_Missense_Mutation_p.A468T|NOL6_uc003ztb.1_Missense_Mutation_p.A520T	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	520					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		TTCAGCCGAGCCCCCAGGCCC	0.647													0	0	0	0.000602	0	4	37										T	33467733	C	T	33467733	3	4	96	1	0	0	0	0	1	0	0	0	10525	739	26	2	1942	2	NOL6	9	33467733	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6561873	33467733	107745698	480	28956										
DCAF12	25853	broad.mit.edu	37	chr9	34107359	34107359	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actactgggaaaacttacatCtcctacacacacaggatcca	5	13	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:34107359C>T	uc003ztt.2	-	3	880	c.538G>A	c.(538-540)GAT>AAT	p.D180N		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	180						centrosome|CUL4 RING ubiquitin ligase complex					0						AAACTTACATCTCCTACACAC	0.502													0	0	0	0.00632	0	29	73										T	34107359	C	T	34107359	3	4	96	1	0	0	0	0	1	0	0	0	4263	913	32	1	851	1	DCAF12	9	34107359	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	639626	34107359	107106072	481	28957										
RG9MTD3	158234	broad.mit.edu	37	chr9	37776350	37776350	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccaatccaggaatacatggtCagaaaccagaatgggaaaaa	9	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:37776350C>T	uc004aai.2	+	8	869	c.792C>T	c.(790-792)GTC>GTT	p.V264V	RG9MTD3_uc011lqo.1_Silent_p.V213V|RG9MTD3_uc011lqp.1_Silent_p.V186V|RG9MTD3_uc011lqq.1_Silent_p.V153V|RG9MTD3_uc004aaj.2_RNA|RG9MTD3_uc004aak.2_Silent_p.V169V	NM_144964	NP_659401	Q6PF06	RG9D3_HUMAN	RNA (guanine-9-) methyltransferase domain	264							methyltransferase activity				0				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)		AATACATGGTCAGAAACCAGA	0.428													0	0	0	0.008291	0	11	12										T	37776350	C	T	37776350	2	4	96	1	0	0	0	0	0	0	0	1	13273	813	29	1		1	RG9MTD3	9	37776350	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3668991	37776350	103437081	482	28958										
MAMDC2	256691	broad.mit.edu	37	chr9	72840940	72840940	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgaggacttaaatgaaattGagtattaagaaatgatctgc	9	4	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:72840940G>C	uc004ahm.2	+	14	2670	c.2053G>C	c.(2053-2055)GAG>CAG	p.E685Q	MAMDC2_uc004ahn.2_RNA|uc004ahq.1_Intron	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	685						endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						AAATGAAATTGAGTATTAAGA	0.299													0	0	0	0.004482	0	7	16										C	72840940	G	C	72840940	3	2	96	1	0	0	0	0	1	0	0	0	9203	1291	45	1	2107	1	MAMDC2	9	72840940	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	35064590	72840940	68372491	483	28959										
SMC5	23137	broad.mit.edu	37	chr9	72962046	72962046	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attaactgaagaaagatcaaGagcttcctgcttcacgggac	9	9	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:72962046G>C	uc004ahr.2	+	20	2750	c.2633G>C	c.(2632-2634)AGA>ACA	p.R878T	SMC5_uc011lry.1_Missense_Mutation_p.R23T	NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	878					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						GAAAGATCAAGAGCTTCCTGC	0.418													0	0	0	0.004482	0	7	23										C	72962046	G	C	72962046	3	2	96	1	0	0	0	0	1	0	0	0	14786	942	33	1	2711	1	SMC5	9	72962046	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	121106	72962046	68251385	484	28960										
C9orf95	54981	broad.mit.edu	37	chr9	77683978	77683978	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catgggccacacatggccatCaaagtatcccggagagtctg	11	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:77683978C>G	uc004aju.2	-	7	1028	c.430G>C	c.(430-432)GAT>CAT	p.D144H	C9orf95_uc004ajs.3_Missense_Mutation_p.D148H|C9orf95_uc004ajr.3_Missense_Mutation_p.D144H|C9orf95_uc004ajt.3_Missense_Mutation_p.D120H	NM_017881	NP_060351	Q9NWW6	NRK1_HUMAN	nicotinamide riboside kinase 1 isoform 1	144					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|ribosylnicotinamide kinase activity				0						ACATGGCCATCAAAGTATCCC	0.413													0	0	0	0.003163	0	15	70										G	77683978	C	G	77683978	3	3	96	1	0	0	0	0	1	0	0	0	2507	826	29	1	181	1	C9orf95	9	77683978	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4721932	77683978	63529453	485	28961										
GKAP1	80318	broad.mit.edu	37	chr9	86368211	86368211	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atttttcagcttctggatttCagcatctttcctttcaagct	5	10	5	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:86368211C>T	uc004amy.2	-	9	1298	c.802G>A	c.(802-804)GAA>AAA	p.E268K	GKAP1_uc004amz.2_Missense_Mutation_p.E217K	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	268	Potential.				signal transduction	Golgi apparatus					0						TTCTGGATTTCAGCATCTTTC	0.323													0	0	0	0.007413	0	19	55										T	86368211	C	T	86368211	3	4	96	1	0	0	0	0	1	0	0	0	6423	835	29	1	318	1	GKAP1	9	86368211	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	8684233	86368211	54845220	486	28962										
STX17	55014	broad.mit.edu	37	chr9	102722413	102722413	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attgaacttagccaactggtCactgacttctctctcctagt	6	12	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:102722413C>T	uc004bal.3	+	6	694	c.558C>T	c.(556-558)GTC>GTT	p.V186V	STX17_uc010msx.2_RNA|STX17_uc011lvd.1_RNA	NM_017919	NP_060389	P56962	STX17_HUMAN	syntaxin 17	186	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCCAACTGGTCACTGACTTCT	0.333													0	0	0	0.002445	0	29	71										T	102722413	C	T	102722413	2	4	96	1	0	0	0	0	0	0	0	1	15339	813	29	1		1	STX17	9	102722413	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	16354202	102722413	38491018	487	28963										
PTPN3	5774	broad.mit.edu	37	chr9	112144604	112144604	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcagtgaactaggacgggctCgctgtccactctcagagacc	12	13	1	2	rs147420952	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:112144604C>T	uc004bed.2	-	24	2618	c.2506G>A	c.(2506-2508)GAG>AAG	p.E836K	PTPN3_uc004beb.2_Missense_Mutation_p.E705K|PTPN3_uc004bec.2_Missense_Mutation_p.E660K|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.E791K|PTPN3_uc011lwh.1_Missense_Mutation_p.E682K|PTPN3_uc011lwd.1_Missense_Mutation_p.E304K|PTPN3_uc011lwe.1_Missense_Mutation_p.E549K|PTPN3_uc011lwf.1_Missense_Mutation_p.E504K	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	836	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						AGGACGGGCTCGCTGTCCACT	0.537													0	0	0	0.00308	0	8	26										T	112144604	C	T	112144604	3	4	96	1	0	0	0	0	1	0	0	0	12789	893	31	1	247	1	PTPN3	9	112144604	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9422191	112144604	29068827	488	28964										
PTPN3	5774	broad.mit.edu	37	chr9	112144707	112144707	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcgacgtactggagatgtgtCactgtgtgttcttccccggt	13	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:112144707C>T	uc004bed.2	-	24	2515	c.2403G>A	c.(2401-2403)GTG>GTA	p.V801V	PTPN3_uc004beb.2_Silent_p.V670V|PTPN3_uc004bec.2_Silent_p.V625V|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.V756V|PTPN3_uc011lwh.1_Silent_p.V647V|PTPN3_uc011lwd.1_Silent_p.V269V|PTPN3_uc011lwe.1_Silent_p.V514V|PTPN3_uc011lwf.1_Silent_p.V469V	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	801	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						GGAGATGTGTCACTGTGTGTT	0.572													0	0	0	0.00245	0	14	34										T	112144707	C	T	112144707	2	4	96	1	0	0	0	0	0	0	0	1	12789	813	29	1		1	PTPN3	9	112144707	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	103	112144707	29068724	489	28965										
SUSD1	64420	broad.mit.edu	37	chr9	114904620	114904620	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttggcaatgtaattttgggGactcccatgtgcccaggcct	11	11	0	0	rs113511367	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:114904620G>A	uc004bfu.2	-	5	727	c.686C>T	c.(685-687)TCC>TTC	p.S229F	SUSD1_uc010mui.2_Missense_Mutation_p.S229F|SUSD1_uc010muj.2_Missense_Mutation_p.S229F	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	229	Sushi 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						TAATTTTGGGGACTCCCATGT	0.418													0	0	0	0.00361	0	61	111										A	114904620	G	A	114904620	3	1	96	1	0	0	0	0	1	0	0	0	15404	1174	41	1	1609	1	SUSD1	9	114904620	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2759913	114904620	26308811	490	28966										
PRPF4	9128	broad.mit.edu	37	chr9	116053935	116053935	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccttcaagctgtggatggctGaatagatgacaatgggaaaa	12	6	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:116053935G>C	uc004bgx.2	+	14	1614	c.1564G>C	c.(1564-1566)GAA>CAA	p.E522Q	PRPF4_uc004bgy.2_Missense_Mutation_p.E521Q	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	522						Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						GTGGATGGCTGAATAGATGAC	0.453													0	0	0	0.007413	0	20	17										C	116053935	G	C	116053935	3	2	96	1	0	0	0	0	1	0	0	0	12570	1291	45	1	1618	1	PRPF4	9	116053935	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1149315	116053935	25159496	491	28967										
NR6A1	2649	broad.mit.edu	37	chr9	127289083	127289083	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttaggaagttaattgctttCatgcaagcatactcctcgtt	7	8	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:127289083C>T	uc004bor.1	-	8	1354	c.1176G>A	c.(1174-1176)ATG>ATA	p.M392I	NR6A1_uc004boq.1_Missense_Mutation_p.M387I|NR6A1_uc010mwq.1_Missense_Mutation_p.M388I	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	392					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						TAATTGCTTTCATGCAAGCAT	0.498													0	0	0	0.005524	0	35	99										T	127289083	C	T	127289083	3	4	96	1	0	0	0	0	1	0	0	0	10637	826	29	1	278	1	NR6A1	9	127289083	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	11235148	127289083	13924348	492	28968										
NR6A1	2649	broad.mit.edu	37	chr9	127289100	127289100	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttcatgcaagcatactcctCgttgctgacctttagctgat	7	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:127289100C>A	uc004bor.1	-	8	1337	c.1159G>T	c.(1159-1161)GAG>TAG	p.E387*	NR6A1_uc004boq.1_Nonsense_Mutation_p.E382*|NR6A1_uc010mwq.1_Nonsense_Mutation_p.E383*	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	387					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GCATACTCCTCGTTGCTGACC	0.498													1	0	1.07637e-12	0.004878	1.34313e-12	38	93										A	127289100	C	A	127289100	4	1	96	1	0	0	0	0	0	1	0	0	10637	893	31	3	295	3	NR6A1	9	127289100	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	17	127289100	13924331	493	28969										
MAPKAP1	79109	broad.mit.edu	37	chr9	128347847	128347847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggattacttgagcttcggctCccgtccttcgcttgtatact	9	12	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:128347847C>T	uc004bpv.2	-	5	991	c.658G>A	c.(658-660)GAG>AAG	p.E220K	MAPKAP1_uc011lzt.1_Missense_Mutation_p.E23K|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Missense_Mutation_p.E23K|MAPKAP1_uc011lzv.1_Missense_Mutation_p.E23K|MAPKAP1_uc004bpw.2_Missense_Mutation_p.E28K|MAPKAP1_uc004bpx.2_Missense_Mutation_p.E28K|MAPKAP1_uc004bpy.2_Missense_Mutation_p.E220K|MAPKAP1_uc004bpz.2_Missense_Mutation_p.E220K|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc010mxb.1_Missense_Mutation_p.E23K|MAPKAP1_uc004bqa.2_Missense_Mutation_p.E220K|MAPKAP1_uc010mxc.1_Missense_Mutation_p.E92K	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	220					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						AGCTTCGGCTCCCGTCCTTCG	0.542													0	0	0	0.001786	0	29	58										T	128347847	C	T	128347847	3	4	96	1	0	0	0	0	1	0	0	0	9288	864	30	1	960	1	MAPKAP1	9	128347847	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1058747	128347847	12865584	494	28970										
ENG	2022	broad.mit.edu	37	chr9	130580997	130580997	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacaggcatgccaggtacctGcacaaagctctgctgccccg	11	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:130580997G>A	uc004bsj.3	-	11	1839	c.1426C>T	c.(1426-1428)CAG>TAG	p.Q476*	ENG_uc011mam.1_Nonsense_Mutation_p.Q287*|ENG_uc004bsk.3_Nonsense_Mutation_p.Q476*|uc004bsl.1_Intron	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	476	Ser/Thr-rich.|Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						CCAGGTACCTGCACAAAGCTC	0.612									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.00361	0	52	79										A	130580997	G	A	130580997	4	1	96	1	0	0	0	0	0	1	0	0	5117	1328	46	2	596	2	ENG	9	130580997	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2233150	130580997	10632434	495	28971										
LCN2	3934	broad.mit.edu	37	chr9	130914210	130914210	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctggattaacgagttacctCgtccgagtggtgagcaccaa	11	11	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:130914210C>T	uc004bto.1	+	4	454	c.381C>T	c.(379-381)CTC>CTT	p.L127L	LCN2_uc011map.1_Silent_p.L127L	NM_005564	NP_005555	P80188	NGAL_HUMAN	lipocalin 2 precursor	127					apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity				0						CGAGTTACCTCGTCCGAGTGG	0.567													0	0	0	0.005443	0	27	57										T	130914210	C	T	130914210	2	4	96	1	0	0	0	0	0	0	0	1	8684	871	31	1		1	LCN2	9	130914210	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	333213	130914210	10299221	496	28972										
CERCAM	51148	broad.mit.edu	37	chr9	131190687	131190687	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcaacttcatccacctgatCttagaagcactaggtgaggg	10	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:131190687C>T	uc004buz.3	+	6	1271	c.873C>T	c.(871-873)ATC>ATT	p.I291I	CERCAM_uc004buy.1_Silent_p.I213I|CERCAM_uc010mxz.2_Silent_p.I213I|CERCAM_uc010mya.1_Silent_p.I132I	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	291					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						TCCACCTGATCTTAGAAGCAC	0.612													0	0	0	0.000602	0	5	26										T	131190687	C	T	131190687	2	4	96	1	0	0	0	0	0	0	0	1	3266	903	32	1		1	CERCAM	9	131190687	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	276477	131190687	10022744	497	28973										
SPTAN1	6709	broad.mit.edu	37	chr9	131369932	131369932	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggggttggtgtcctcagatGagctagccaaggatgtcacc	15	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:131369932G>T	uc004bvl.3	+	32	4209	c.4096G>T	c.(4096-4098)GAG>TAG	p.E1366*	SPTAN1_uc004bvm.3_Nonsense_Mutation_p.E1366*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.E1346*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1366	Spectrin 15.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GTCCTCAGATGAGCTAGCCAA	0.542													1	0	1.78839e-46	0.00361	2.29321e-46	73	94										T	131369932	G	T	131369932	4	4	96	1	0	0	0	0	0	1	0	0	15116	1291	45	3	4218	3	SPTAN1	9	131369932	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	179245	131369932	9843499	498	28974										
NUP188	23511	broad.mit.edu	37	chr9	131768878	131768878	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccgcagggcaagtccacctCtctctccaaagccagccctg	9	18	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:131768878C>G	uc004bws.1	+	44	5193	c.5171C>G	c.(5170-5172)TCT>TGT	p.S1724C		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1724					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						AAGTCCACCTCTCTCTCCAAA	0.637											OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003214	0	46	45										G	131768878	C	G	131768878	3	3	96	1	0	0	0	0	1	0	0	0	10758	913	32	1	5345	1	NUP188	9	131768878	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	398946	131768878	9444553	499	28975										
TSC1	7248	broad.mit.edu	37	chr9	135776115	135776115	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcatacctttgtggtatctGagtgcttgttctgcagttgt	12	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:135776115G>C	uc004cca.2	-	20	2846	c.2612C>G	c.(2611-2613)TCA>TGA	p.S871*	TSC1_uc004ccb.3_Nonsense_Mutation_p.S870*|TSC1_uc011mcq.1_Nonsense_Mutation_p.S820*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	871	Potential.				activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TGTGGTATCTGAGTGCTTGTT	0.527			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.00361	0	54	82										C	135776115	G	C	135776115	4	2	96	1	0	0	0	0	0	1	0	0	16602	1294	45	1	898	1	TSC1	9	135776115	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4007237	135776115	5437316	500	28976										
RALGDS	5900	broad.mit.edu	37	chr9	135979668	135979668	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accgtctccttcggccgtttCtgggctctcttggggttcat	11	13	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:135979668C>G	uc004cco.2	-	10	1673	c.1653G>C	c.(1651-1653)CAG>CAC	p.Q551H	RALGDS_uc004ccn.2_5'Flank|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.Q539H|RALGDS_uc004ccr.2_Missense_Mutation_p.Q550H|RALGDS_uc011mcv.1_Missense_Mutation_p.Q522H|RALGDS_uc004ccs.2_Missense_Mutation_p.Q496H|RALGDS_uc011mcw.1_Missense_Mutation_p.Q622H|RALGDS_uc004ccv.1_Missense_Mutation_p.Q320H|RALGDS_uc004ccu.1_Missense_Mutation_p.Q320H	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	551	Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TCGGCCGTTTCTGGGCTCTCT	0.662			T	CIITA	PMBL|Hodgkin Lymphona|								0	0	0	0.004007	0	16	34										G	135979668	C	G	135979668	3	3	96	1	0	0	0	0	1	0	0	0	13016	912	32	1	1127	1	RALGDS	9	135979668	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	203553	135979668	5233763	501	28977										
KCNT1	57582	broad.mit.edu	37	chr9	138657499	138657499	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggtcatcctgtgccccacGgagatggatgtccaggtgcg	15	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:138657499G>A	uc011mdq.1	+	13	1304	c.1230G>A	c.(1228-1230)ACG>ACA	p.T410T	KCNT1_uc011mdr.1_Silent_p.T237T|KCNT1_uc010nbf.2_Silent_p.T365T|KCNT1_uc004cgo.1_Silent_p.T159T	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	410						membrane	binding|calcium-activated potassium channel activity	p.T410M(1)		large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		TGTGCCCCACGGAGATGGATG	0.657													0	0	0	0.000602	0	5	10										A	138657499	G	A	138657499	2	1	96	1	0	0	0	0	0	0	0	1	8091	1103	39	2		2	KCNT1	9	138657499	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2677831	138657499	2555932	502	28978										
NOTCH1	4851	broad.mit.edu	37	chr9	139390629	139390629	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggaatgcggggacgagctgGaccactggtcaggggactca	17	9	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:139390629G>A	uc004chz.2	-	34	7562	c.7562C>T	c.(7561-7563)TCC>TTC	p.S2521F		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2521	Poly-Ser.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.W2521*(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGACGAGCTGGACCACTGGTC	0.662			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.000978	0	8	33										A	139390629	G	A	139390629	3	1	96	1	0	0	0	0	1	0	0	0	10547	1174	41	1	109	1	NOTCH1	9	139390629	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	733130	139390629	1822802	503	28979										
NPDC1	56654	broad.mit.edu	37	chr9	139937506	139937506	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcagggcacagtccaggctCccgggacaggcggctacatc	13	14	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr9:139937506C>T	uc004ckt.2	-	2	367	c.132G>A	c.(130-132)GGG>GGA	p.G44G	NPDC1_uc004ckr.2_Silent_p.G44G|NPDC1_uc004cks.2_Silent_p.G122G|NPDC1_uc004cku.2_Silent_p.G44G	NM_015392	NP_056207	Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and	44						integral to membrane					0	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		AGTCCAGGCTCCCGGGACAGG	0.697													0	0	0	0.001168	0	4	23										T	139937506	C	T	139937506	2	4	96	1	0	0	0	0	0	0	0	1	10573	842	30	1		1	NPDC1	9	139937506	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	546877	139937506	1275925	504	28980										
OPTN	10133	broad.mit.edu	37	chr10	13154581	13154581	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcgtgtctgaactgcagctCaagctgaactccagcggctc	10	13	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:13154581C>G	uc001ilu.1	+	6	936	c.498C>G	c.(496-498)CTC>CTG	p.L166L	OPTN_uc001ilv.1_Silent_p.L166L|OPTN_uc001ilw.1_Silent_p.L166L|OPTN_uc001ilx.1_Silent_p.L166L|OPTN_uc001ily.1_Silent_p.L166L|OPTN_uc010qbr.1_Silent_p.L109L|OPTN_uc001ilz.1_Silent_p.L166L	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	166	Interaction with Rab8.|Potential.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						AACTGCAGCTCAAGCTGAACT	0.498													0	0	0	0.002096	0	28	88										G	13154581	C	G	13154581	2	3	96	1	0	0	0	0	0	0	0	1	10889	813	29	1		1	OPTN	10	13154581	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		13154581	122380166	505	28981										
ACBD7	414149	broad.mit.edu	37	chr10	15121001	15121001	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccatcatctggtcttgctttCagcttcctcacatcttctgc	5	15	7	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:15121001C>T	uc001inv.2	-	2	99	c.51G>A	c.(49-51)CTG>CTA	p.L17L	ACBD7_uc010qby.1_5'UTR	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	17	ACB.						fatty-acyl-CoA binding				0						GTCTTGCTTTCAGCTTCCTCA	0.358													0	0	0	0.007835	0	33	93										T	15121001	C	T	15121001	2	4	96	1	0	0	0	0	0	0	0	1	127	813	29	1		1	ACBD7	10	15121001	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1966420	15121001	120413746	506	28982										
MLLT10	8028	broad.mit.edu	37	chr10	22002839	22002839	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtaggagcgctctctccctCagctgtgtcatctgcagccc	10	15	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:22002839C>T	uc001iqs.2	+	15	2234	c.1886C>T	c.(1885-1887)TCA>TTA	p.S629L	MLLT10_uc001iqt.2_Missense_Mutation_p.S613L|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.S613L|MLLT10_uc001ira.2_Missense_Mutation_p.S70L|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	629	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						CTCTCTCCCTCAGCTGTGTCA	0.473			T	MLL|PICALM|CDK6	AL								0	0	0	0.001523	0	20	78										T	22002839	C	T	22002839	3	4	96	1	0	0	0	0	1	0	0	0	9626	838	29	1	1940	1	MLLT10	10	22002839	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6881838	22002839	113531908	507	28983										
C10orf67	256815	broad.mit.edu	37	chr10	23611391	23611391	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagagactcaaagattcctCtttcagtcggtcctcaaact	7	11	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:23611391C>G	uc010qcx.1	-	3	472	c.406G>C	c.(406-408)GAG>CAG	p.E136Q		NM_153714	NP_714925	Q8IYJ2	CJ067_HUMAN	hypothetical protein LOC256815	136											0						AAAGATTCCTCTTTCAGTCGG	0.328													0	0	0	0.006122	0	16	103										G	23611391	C	G	23611391	3	3	96	1	0	0	0	0	1	0	0	0	1612	922	32	1	163	1	C10orf67	10	23611391	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1608552	23611391	111923356	508	28984										
SVIL	6840	broad.mit.edu	37	chr10	29820964	29820964	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcgttctgctgaagttataGgttgggttctaaatctctcg	10	7	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:29820964G>T	uc001iut.1	-	9	2729	c.1976C>A	c.(1975-1977)CCT>CAT	p.P659H	SVIL_uc001iuu.1_Intron	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	659					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TGAAGTTATAGGTTGGGTTCT	0.488													1	0	1.15919e-05	0.008871	1.39568e-05	18	139										T	29820964	G	T	29820964	3	4	96	1	0	0	0	0	1	0	0	0	15418	1000	35	4	4788	4	SVIL	10	29820964	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6209573	29820964	105713783	509	28985										
ZNF33A	7581	broad.mit.edu	37	chr10	38306269	38306269	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcaggctgcaacaaggagaaGagccatggaaacaggaggaa	14	7	1	2	rs582502		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:38306269G>A	uc001izh.2	+	4	383	c.205G>A	c.(205-207)GAG>AAG	p.E69K	ZNF33A_uc001izg.2_Missense_Mutation_p.E69K|ZNF33A_uc010qev.1_Missense_Mutation_p.E76K|ZNF33A_uc001izi.1_Missense_Mutation_p.E69K|ZNF33A_uc001izj.2_RNA	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	69	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						ACAAGGAGAAGAGCCATGGAA	0.433													0	0	0	0.00361	0	54	143										A	38306269	G	A	38306269	3	1	96	1	0	0	0	0	1	0	0	0	17851	943	33	1	215	1	ZNF33A	10	38306269	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8485305	38306269	97228478	510	28986										
ZNF33B	7582	broad.mit.edu	37	chr10	43089326	43089326	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttttccacattgattacattGaaagtgtttctctcctgtgt	6	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:43089326G>A	uc001jaf.1	-	5	1187	c.1072C>T	c.(1072-1074)CAA>TAA	p.Q358*	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Nonsense_Mutation_p.Q246*|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	358	C2H2-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGATTACATTGAAAGTGTTTC	0.418													0	0	0	0.007835	0	42	104										A	43089326	G	A	43089326	4	1	96	1	0	0	0	0	0	1	0	0	17852	1299	45	1	1268	1	ZNF33B	10	43089326	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4783057	43089326	92445421	511	28987										
RET	5979	broad.mit.edu	37	chr10	43601965	43601965	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggtggaacactggcccaacGagacctcggtccaggccaac	13	14	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:43601965G>A	uc001jal.2	+	5	1199	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	RET_uc001jak.1_Missense_Mutation_p.E337K|RET_uc010qez.1_Missense_Mutation_p.E83K	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	337	Extracellular (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CTGGCCCAACGAGACCTCGGT	0.652		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	0.008291	0	11	20										A	43601965	G	A	43601965	3	1	96	1	0	0	0	0	1	0	0	0	13235	1059	37	1	1027	1	RET	10	43601965	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	512639	43601965	91932782	512	28988										
ALOX5	240	broad.mit.edu	37	chr10	45877975	45877975	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacgaggaactgggcgagatCcagctggtcagaatcgagaa	15	8	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:45877975C>T	uc001jce.2	+	2	294	c.195C>T	c.(193-195)ATC>ATT	p.I65I	ALOX5_uc009xmt.2_Silent_p.I65I|ALOX5_uc010qfg.1_Silent_p.I65I	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	65	PLAT.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TGGGCGAGATCCAGCTGGTCA	0.547													0	0	0	0.007413	0	17	53										T	45877975	C	T	45877975	2	4	96	1	0	0	0	0	0	0	0	1	540	845	30	1		1	ALOX5	10	45877975	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2276010	45877975	89656772	513	28989										
ERCC6	2074	broad.mit.edu	37	chr10	50690842	50690842	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaagatgaagtcaaagagcGaccacagctctcggaggtta	13	8	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:50690842G>C	uc001jhs.3	-	10	2214	c.2060C>G	c.(2059-2061)TCG>TGG	p.S687W	ERCC6_uc010qgr.1_Missense_Mutation_p.S57W|ERCC6_uc001jhr.3_Missense_Mutation_p.S87W	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	687	Helicase ATP-binding.		S -> L (in CSB).		base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GTCAAAGAGCGACCACAGCTC	0.483								Direct_reversal_of_damage|NER					0	0	0	0.004878	0	35	64										C	50690842	G	C	50690842	3	2	96	1	0	0	0	0	1	0	0	0	5217	1059	37	1	2469	1	ERCC6	10	50690842	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4812867	50690842	84843905	514	28990										
TFAM	7019	broad.mit.edu	37	chr10	60145995	60145995	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtagttttgtgtatttaccGaggtggttttcatctgtctt	10	5	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:60145995G>A	uc001jkf.2	+	2	249	c.117G>A	c.(115-117)CCG>CCA	p.P39P	TFAM_uc001jkg.2_RNA|TFAM_uc001jkh.2_Silent_p.P39P	NM_003201	NP_003192	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial precursor	39					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TGTATTTACCGAGGTGGTTTT	0.338													0	0	0	0.007291	0	27	70										A	60145995	G	A	60145995	2	1	96	1	0	0	0	0	0	0	0	1	15783	1045	37	1		1	TFAM	10	60145995	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9455153	60145995	75388752	515	28991										
MYPN	84665	broad.mit.edu	37	chr10	69926110	69926110	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccaactctaccaccaacctgGcagctattgagccacagccc	6	18	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:69926110G>A	uc001jnm.3	+	11	1845	c.1660G>A	c.(1660-1662)GCA>ACA	p.A554T	MYPN_uc001jnl.1_Missense_Mutation_p.A554T|MYPN_uc001jnn.3_Missense_Mutation_p.A279T|MYPN_uc001jno.3_Missense_Mutation_p.A554T|MYPN_uc009xps.2_Missense_Mutation_p.A554T|MYPN_uc009xpt.2_Missense_Mutation_p.A554T|MYPN_uc010qit.1_Missense_Mutation_p.A260T|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	554						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CACCAACCTGGCAGCTATTGA	0.552													0	0	0	0.001855	0	11	56										A	69926110	G	A	69926110	3	1	96	1	0	0	0	0	1	0	0	0	10098	1203	42	2	1694	2	MYPN	10	69926110	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9780115	69926110	65608637	516	28992										
TET1	80312	broad.mit.edu	37	chr10	70412289	70412289	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaggaaacgcaataaggataGaaatagtagtgtacaccggt	11	5	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:70412289G>A	uc001jok.3	+	6	4904	c.4399G>A	c.(4399-4401)GAA>AAA	p.E1467K		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1467					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						AATAAGGATAGAAATAGTAGT	0.363													0	0	0	0.00278	0	19	46										A	70412289	G	A	70412289	3	1	96	1	0	0	0	0	1	0	0	0	15766	943	33	1	4417	1	TET1	10	70412289	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	486179	70412289	65122458	517	28993										
TET1	80312	broad.mit.edu	37	chr10	70412337	70412337	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaaaagctctcatgggtgtCcaattgctaagtgggtaagt	13	6	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:70412337C>G	uc001jok.3	+	6	4952	c.4447C>G	c.(4447-4449)CCA>GCA	p.P1483A		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1483					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCATGGGTGTCCAATTGCTAA	0.348													0	0	0	0.001855	0	12	46										G	70412337	C	G	70412337	3	3	96	1	0	0	0	0	1	0	0	0	15766	855	30	1	4465	1	TET1	10	70412337	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	48	70412337	65122410	518	28994										
DDX21	9188	broad.mit.edu	37	chr10	70719870	70719870	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatgctcctaagcccaagaaGatgaagaaagaaaaggaaat	10	6	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:70719870G>A	uc001jov.1	+	2	486	c.396G>A	c.(394-396)AAG>AAA	p.K132K	DDX21_uc001jow.1_Silent_p.K64K	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	132						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						AGCCCAAGAAGATGAAGAAAG	0.408													0	0	0	0.008291	0	11	42										A	70719870	G	A	70719870	2	1	96	1	0	0	0	0	0	0	0	1	4349	933	33	1		1	DDX21	10	70719870	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	307533	70719870	64814877	519	28995										
FUT11	170384	broad.mit.edu	37	chr10	75532615	75532615	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctccaccttcagtcgccactCggattacccgctgtcgctgc	8	18	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:75532615C>G	uc001jva.2	+	1	567	c.524C>G	c.(523-525)TCG>TGG	p.S175W	FUT11_uc001juy.1_Missense_Mutation_p.S175W|FUT11_uc001juz.1_Missense_Mutation_p.S175W	NM_173540	NP_775811	Q495W5	FUT11_HUMAN	fucosyltransferase 11 (alpha (1,3)	175	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	Prostate(51;0.0112)					AGTCGCCACTCGGATTACCCG	0.687													0	0	0	0.006122	0	16	36										G	75532615	C	G	75532615	3	3	96	1	0	0	0	0	1	0	0	0	6103	893	31	1	526	1	FUT11	10	75532615	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4812745	75532615	60002132	520	28996										
DUPD1	338599	broad.mit.edu	37	chr10	76803619	76803619	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tagaagaagacactgaggtcGaaggtgggcaggtcgtcggc	17	7	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:76803619G>C	uc001jwq.1	-	2	357	c.357C>G	c.(355-357)TTC>TTG	p.F119L		NM_001003892	NP_001003892	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase	119	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)	2	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CACTGAGGTCGAAGGTGGGCA	0.577													0	0	0	0.007413	0	18	68										C	76803619	G	C	76803619	3	2	96	1	0	0	0	0	1	0	0	0	4804	1049	37	1	313	1	DUPD1	10	76803619	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1271004	76803619	58731128	521	28997										
PAPSS2	9060	broad.mit.edu	37	chr10	89501082	89501082	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgggctggaccaataccgtCtgacacctctggagctcaaa	10	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:89501082C>T	uc001kex.2	+	9	1425	c.1162C>T	c.(1162-1164)CTG>TTG	p.L388L	PAPSS2_uc001kew.2_Silent_p.L393L	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	388	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CCAATACCGTCTGACACCTCT	0.378													0	0	0	0.006214	0	9	76										T	89501082	C	T	89501082	2	4	96	1	0	0	0	0	0	0	0	1	11435	912	32	1		1	PAPSS2	10	89501082	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	12697463	89501082	46033665	522	28998										
IFIT3	3437	broad.mit.edu	37	chr10	91099478	91099478	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ataaggaagtccctgatgctGaaaagcaacaatcccatcag	8	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:91099478G>A	uc001kgf.2	+	2	1295	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Missense_Mutation_p.E356K	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	356					type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1						CCCTGATGCTGAAAAGCAACA	0.453													0	0	0	0.003954	0	27	38										A	91099478	G	A	91099478	3	1	96	1	0	0	0	0	1	0	0	0	7524	1291	45	1	1081	1	IFIT3	10	91099478	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1598396	91099478	44435269	523	28999										
CPN1	1369	broad.mit.edu	37	chr10	101841262	101841262	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccgcgtgatgccggggcattCgttttgcaccttgtacagcg	13	12	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:101841262C>G	uc001kql.2	-	1	381	c.121G>C	c.(121-123)GAA>CAA	p.E41Q		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	41	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		CCGGGGCATTCGTTTTGCACC	0.597													0	0	0	0.001882	0	21	36										G	101841262	C	G	101841262	3	3	96	1	0	0	0	0	1	0	0	0	3809	893	31	1	1291	1	CPN1	10	101841262	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10741784	101841262	33693485	524	29000										
PKD2L1	9033	broad.mit.edu	37	chr10	102089772	102089772	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctcagcgtcccgtgtgggGaagggggaccactgtaggcg	17	11	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:102089772G>A	uc001kqx.1	-	1	472	c.89C>T	c.(88-90)TCC>TTC	p.S30F	PKD2L1_uc009xwm.1_5'UTR	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	30	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CCCGTGTGGGGAAGGGGGACC	0.622													0	0	0	0.002222	0	39	80										A	102089772	G	A	102089772	3	1	96	1	0	0	0	0	1	0	0	0	11967	1174	41	1	2392	1	PKD2L1	10	102089772	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	248510	102089772	33444975	525	29001										
CNNM2	54805	broad.mit.edu	37	chr10	104678701	104678701	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcgatgcggcatccgcacctCagacatcatcatcttgcccc	8	17	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:104678701C>G	uc001kwm.2	+	1	588	c.464C>G	c.(463-465)TCA>TGA	p.S155*	CNNM2_uc001kwn.2_Nonsense_Mutation_p.S155*|CNNM2_uc001kwl.2_Nonsense_Mutation_p.S155*	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	155					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATCCGCACCTCAGACATCATC	0.502													0	0	0	0.004656	0	28	196										G	104678701	C	G	104678701	4	3	96	1	0	0	0	0	0	1	0	0	3613	838	29	1	466	1	CNNM2	10	104678701	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2588929	104678701	30856046	526	29002										
CNNM2	54805	broad.mit.edu	37	chr10	104816644	104816644	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccaggaactgaaatatgatGagaagaacaagaaagccccc	9	9	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:104816644G>A	uc001kwm.2	+	4	2120	c.1996G>A	c.(1996-1998)GAG>AAG	p.E666K	CNNM2_uc001kwn.2_Missense_Mutation_p.E666K	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	666					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GAAATATGATGAGAAGAACAA	0.433													0	0	0	0.005524	0	35	98										A	104816644	G	A	104816644	3	1	96	1	0	0	0	0	1	0	0	0	3613	1291	45	1	2052	1	CNNM2	10	104816644	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	137943	104816644	30718103	527	29003										
ABLIM1	3983	broad.mit.edu	37	chr10	116307536	116307536	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttccgcagccggcacaatCtgaaaaagagcagccgccag	10	14	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:116307536C>G	uc010qsg.1	-	5	773	c.674_splice	c.e5-1	p.N225_splice	ABLIM1_uc010qsh.1_Splice_Site_p.N165_splice|ABLIM1_uc010qsi.1_Splice_Site_p.N165_splice|ABLIM1_uc010qsk.1_Splice_Site_p.N149_splice|ABLIM1_uc009xyp.2_Splice_Site_p.N159_splice|ABLIM1_uc009xyo.2_Splice_Site_p.N73_splice	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a						axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CCGGCACAATCTGAAAAAGAG	0.522													0	0	0	0.004482	0	8	32										G	116307536	C	G	116307536	5	3	96	1	0	0	0	0	0	0	1	0	94	927	32	1	1823	1	ABLIM1	10	116307536	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	11490892	116307536	19227211	528	29004										
INPP5F	22876	broad.mit.edu	37	chr10	121586615	121586615	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgggcagtcggtcccagtctCttagcagcacagatagtagc	12	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:121586615C>G	uc001leo.2	+	20	2888	c.2722C>G	c.(2722-2724)CTT>GTT	p.L908V	INPP5F_uc001lep.2_Missense_Mutation_p.L298V	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	908							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		GTCCCAGTCTCTTAGCAGCAC	0.488													0	0	0	0.001855	0	14	68										G	121586615	C	G	121586615	3	3	96	1	0	0	0	0	1	0	0	0	7758	913	32	1	2800	1	INPP5F	10	121586615	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5279079	121586615	13948132	529	29005										
TACC2	10579	broad.mit.edu	37	chr10	123844900	123844900	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtcagtcctcgagggtctCgcctccagcagcagatgtct	12	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:123844900C>G	uc001lfv.2	+	4	3245	c.2885C>G	c.(2884-2886)TCG>TGG	p.S962W	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.S962W|TACC2_uc010qtv.1_Missense_Mutation_p.S962W	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	962						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TCGAGGGTCTCGCCTCCAGCA	0.537													0	0	0	0.002836	0	34	78										G	123844900	C	G	123844900	3	3	96	1	0	0	0	0	1	0	0	0	15499	893	31	1	2895	1	TACC2	10	123844900	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2258285	123844900	11689847	530	29006										
DMBT1	1755	broad.mit.edu	37	chr10	124380654	124380654	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaggtcctgtatcgaggctCctggggaaccgtgtgtgatg	17	8	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:124380654C>T	uc001lgk.1	+	41	5085	c.4979C>T	c.(4978-4980)TCC>TTC	p.S1660F	DMBT1_uc001lgl.1_Missense_Mutation_p.S1650F|DMBT1_uc001lgm.1_Missense_Mutation_p.S1032F|DMBT1_uc009xzz.1_Missense_Mutation_p.S1660F|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Missense_Mutation_p.S363F|DMBT1_uc009yac.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1660	SRCR 13.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TATCGAGGCTCCTGGGGAACC	0.587													0	0	0	0.00361	0	101	231										T	124380654	C	T	124380654	3	4	96	1	0	0	0	0	1	0	0	0	4577	855	30	1	5141	1	DMBT1	10	124380654	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	535754	124380654	11154093	531	29007										
DMBT1	1755	broad.mit.edu	37	chr10	124390773	124390773	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccacaactgtaatcatcgtGaagatgctggtgtcatctgc	9	11	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:124390773G>A	uc001lgk.1	+	46	6041	c.5935G>A	c.(5935-5937)GAA>AAA	p.E1979K	DMBT1_uc001lgl.1_Missense_Mutation_p.E1969K|DMBT1_uc001lgm.1_Missense_Mutation_p.E1351K|DMBT1_uc009xzz.1_Missense_Mutation_p.E1979K|DMBT1_uc010qtx.1_Missense_Mutation_p.E699K|DMBT1_uc009yab.1_Missense_Mutation_p.E682K|DMBT1_uc009yac.1_Missense_Mutation_p.E273K	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1979	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TAATCATCGTGAAGATGCTGG	0.537													0	0	0	0.003271	0	30	139										A	124390773	G	A	124390773	3	1	96	1	0	0	0	0	1	0	0	0	4577	1291	45	1	6117	1	DMBT1	10	124390773	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10119	124390773	11143974	532	29008										
DHX32	55760	broad.mit.edu	37	chr10	127542652	127542652	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttggcatcttttttctgtttCatcgagtggcttgaacaatg	9	7	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:127542652C>T	uc001ljf.1	-	4	1461	c.970G>A	c.(970-972)GAA>AAA	p.E324K	DHX32_uc001lje.1_5'UTR|DHX32_uc001ljg.1_Missense_Mutation_p.E324K|DHX32_uc009yam.1_Intron	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	324						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTTTCTGTTTCATCGAGTGGC	0.388													0	0	0	0.00245	0	13	106										T	127542652	C	T	127542652	3	4	96	1	0	0	0	0	1	0	0	0	4505	835	29	1	1293	1	DHX32	10	127542652	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3151879	127542652	7992095	533	29009										
MKI67	4288	broad.mit.edu	37	chr10	129903899	129903899	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcttctagtgattgggcctCttccttaggtgttcttggcc	11	10	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:129903899C>G	uc001lke.2	-	13	6400	c.6205G>C	c.(6205-6207)GAG>CAG	p.E2069Q	MKI67_uc001lkf.2_Missense_Mutation_p.E1709Q|MKI67_uc009yav.1_Missense_Mutation_p.E1644Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1219Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2069	16 X 122 AA approximate repeats.|9.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GATTGGGCCTCTTCCTTAGGT	0.483													0	0	0	0.00361	0	64	320										G	129903899	C	G	129903899	3	3	96	1	0	0	0	0	1	0	0	0	9598	922	32	1	3577	1	MKI67	10	129903899	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2361247	129903899	5630848	534	29010										
MKI67	4288	broad.mit.edu	37	chr10	129904445	129904445	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaatgctaaaaattcttcctCtacgtctgctttcttgaggc	7	10	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr10:129904445C>G	uc001lke.2	-	13	5854	c.5659G>C	c.(5659-5661)GAG>CAG	p.E1887Q	MKI67_uc001lkf.2_Missense_Mutation_p.E1527Q|MKI67_uc009yav.1_Missense_Mutation_p.E1462Q|MKI67_uc009yaw.1_Missense_Mutation_p.E1037Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1887	16 X 122 AA approximate repeats.|8.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				AATTCTTCCTCTACGTCTGCT	0.458													0	0	0	0.00874	0	42	346										G	129904445	C	G	129904445	3	3	96	1	0	0	0	0	1	0	0	0	9598	922	32	1	4123	1	MKI67	10	129904445	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	546	129904445	5630302	535	29011										
CDHR5	53841	broad.mit.edu	37	chr11	618014	618014	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcttgtggacaaggacggcGaggccaaggagagccagcag	17	9	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:618014G>A	uc001lqj.2	-	14	2163	c.2058C>T	c.(2056-2058)CTC>CTT	p.L686L	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Silent_p.L492L|CDHR5_uc009ycc.2_Silent_p.L520L|CDHR5_uc009ycd.2_Silent_p.L680L|CDHR5_uc001lql.2_Silent_p.L686L	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	686	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CAAGGACGGCGAGGCCAAGGA	0.682													0	0	0	0.001984	0	7	27										A	618014	G	A	618014	2	1	96	1	0	0	0	0	0	0	0	1	3122	1045	37	1		1	CDHR5	11	618014	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		618014	134388502	536	29012										
MUC5B	727897	broad.mit.edu	37	chr11	1157932	1157932	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gactggcggggccctgacttCtgccgtgagtgtcccagccc	14	15	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:1157932C>G	uc009ycr.1	+	9	1125	c.999C>G	c.(997-999)TTC>TTG	p.F333L		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCCTGACTTCTGCCGTGAGT	0.687													0	0	0	0.006214	0	8	47										G	1157932	C	G	1157932	3	3	96	1	0	0	0	0	1	0	0	0	9979	928	32	1		1	MUC5B	11	1157932	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	539918	1157932	133848584	537	29013										
TRIM3	10612	broad.mit.edu	37	chr11	6470362	6470362	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgtggaccatacagtggttCtgcagatgtgttgatatagg	13	6	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:6470362C>T	uc001mdh.2	-	13	2518	c.2131G>A	c.(2131-2133)GAA>AAA	p.E711K	TRIM3_uc001mdi.2_Missense_Mutation_p.E711K|TRIM3_uc010raj.1_Missense_Mutation_p.E592K|TRIM3_uc009yfd.2_Missense_Mutation_p.E711K	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	711	NHL 6.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACAGTGGTTCTGCAGATGTG	0.547													0	0	0	0.008871	0	18	40										T	6470362	C	T	6470362	3	4	96	1	0	0	0	0	1	0	0	0	16501	922	32	1	107	1	TRIM3	11	6470362	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5312430	6470362	128536154	538	29014										
DNHD1	144132	broad.mit.edu	37	chr11	6592126	6592126	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atctgctgacccacgtgattCgccaagacgagtccgacgcc	10	15	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:6592126C>T	uc001mdw.3	+	42	13948	c.13384C>T	c.(13384-13386)CGC>TGC	p.R4462C	DNHD1_uc001mea.3_Missense_Mutation_p.R731C|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.R730C|DNHD1_uc010rao.1_Missense_Mutation_p.R720C|DNHD1_uc009yfg.2_Missense_Mutation_p.R87C	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4462					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCACGTGATTCGCCAAGACGA	0.627													0	0	0	0.00499	0	18	42										T	6592126	C	T	6592126	3	4	96	1	0	0	0	0	1	0	0	0	4668	884	31	1	13551	1	DNHD1	11	6592126	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	121764	6592126	128414390	539	29015										
IPO7	10527	broad.mit.edu	37	chr11	9435956	9435956	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agatcttctatgctcttgttCaggtaatatctgtgaagcag	9	7	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:9435956C>T	uc001mho.2	+	5	776	c.634C>T	c.(634-636)CAG>TAG	p.Q212*		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	212					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGCTCTTGTTCAGGTAATATC	0.343													0	0	0	0.006214	0	8	71										T	9435956	C	T	9435956	4	4	96	1	0	0	0	0	0	1	0	0	7797	827	29	1	652	1	IPO7	11	9435956	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2843830	9435956	125570560	540	29016										
SBF2	81846	broad.mit.edu	37	chr11	9838482	9838482	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttactgaaggaggccgagtGatccttgcctgccagccggg	15	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:9838482G>A	uc001mib.2	-	29	4021	c.3883C>T	c.(3883-3885)CAC>TAC	p.H1295Y	SBF2_uc001mid.2_5'UTR	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1295	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GAGGCCGAGTGATCCTTGCCT	0.507													0	0	0	0.001368	0	13	59										A	9838482	G	A	9838482	3	1	96	1	0	0	0	0	1	0	0	0	13859	1290	45	1	1714	1	SBF2	11	9838482	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	402526	9838482	125168034	541	29017										
SBF2	81846	broad.mit.edu	37	chr11	10014566	10014566	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgtattactggctctgcatGaattcttataagttgcaggc	9	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:10014566G>A	uc001mib.2	-	11	1276	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	SBF2_uc001mif.3_Missense_Mutation_p.H136Y	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	380	dDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GGCTCTGCATGAATTCTTATA	0.318													0	0	0	0.003271	0	32	81										A	10014566	G	A	10014566	3	1	96	1	0	0	0	0	1	0	0	0	13859	1290	45	1	4531	1	SBF2	11	10014566	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	176084	10014566	124991950	542	29018										
EIF4G2	1982	broad.mit.edu	37	chr11	10823639	10823640	+	Frame_Shift_Del	DEL	TG	TG	-													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccatctctccaaactgcgatTgtgtgggaggcatgatgtgt							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:10823639_10823640delTG	uc001mjc.2	-	13	1672_1673	c.1255_1256delCA	c.(1255-1257)CAAfs	p.Q419fs	EIF4G2_uc001mjb.2_Frame_Shift_Del_p.Q213fs|EIF4G2_uc009ygf.2_Frame_Shift_Del_p.Q213fs|EIF4G2_uc001mjd.2_Frame_Shift_Del_p.Q419fs|EIF4G2_uc001mjf.1_Frame_Shift_Del_p.Q213fs|SNORD97_uc009yge.2_5'Flank	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	419					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAACTGCGATTGTGTGGGAGGC	0.431																		15	109	---	---								-	10823640	TG	-	10823639	7	5	96	1	0	1	0	1	0	0	0	0	5037	1812	63	0	1507	0	EIF4G2	11	10823639	Frame_Shift_Del	DEL	TG	TCGA-G2-A2EO-01A-11D-A17V-08	809073	10823639	124182877	543	29019										
MICALCL	84953	broad.mit.edu	37	chr11	12341262	12341262	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gactccaagaactttcccctCagagcacaggtaacagaggc	9	13	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:12341262C>T	uc001mkg.1	+	4	1737	c.1446C>T	c.(1444-1446)CTC>CTT	p.L482L		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	482					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		ACTTTCCCCTCAGAGCACAGG	0.468													0	0	0	0.002445	0	32	111										T	12341262	C	T	12341262	2	4	96	1	0	0	0	0	0	0	0	1	9572	813	29	1		1	MICALCL	11	12341262	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1517623	12341262	122665254	544	29020										
BTBD10	84280	broad.mit.edu	37	chr11	13435141	13435141	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agatagtcacatgcttctctCagttcaggaatagatatgcc	8	9	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:13435141C>T	uc001mkz.2	-	6	1001	c.744G>A	c.(742-744)CTG>CTA	p.L248L	BTBD10_uc010rcl.1_Silent_p.L256L|BTBD10_uc001mla.2_Silent_p.L232L|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Silent_p.L200L|BTBD10_uc010rcn.1_Silent_p.L217L|BTBD10_uc009ygo.2_Silent_p.L200L	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	248						nucleus					0				Epithelial(150;0.0214)		ATGCTTCTCTCAGTTCAGGAA	0.328													0	0	0	0.00308	0	8	61										T	13435141	C	T	13435141	2	4	96	1	0	0	0	0	0	0	0	1	1538	813	29	1		1	BTBD10	11	13435141	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1093879	13435141	121571375	545	29021										
HPS5	11234	broad.mit.edu	37	chr11	18309162	18309162	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgatgatgacaaagttgtatGatatccgatggcaaaatgga	11	4	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:18309162G>A	uc001mod.1	-	18	2915	c.2637C>T	c.(2635-2637)ATC>ATT	p.I879I	HPS5_uc001moe.1_Silent_p.I765I|HPS5_uc001mof.1_Silent_p.I765I	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	879						cytosol				ovary(1)|pancreas(1)|skin(1)	3						AAAGTTGTATGATATCCGATG	0.393									Hermansky-Pudlak_syndrome				0	0	0	0.007413	0	20	50										A	18309162	G	A	18309162	2	1	96	1	0	0	0	0	0	0	0	1	7342	1280	45	1		1	HPS5	11	18309162	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4874021	18309162	116697354	546	29022										
MUC15	143662	broad.mit.edu	37	chr11	26584757	26584757	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccacaagagtaagcaatgaGacacccagaatagcacctaa	7	12	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:26584757G>C	uc001mqx.2	-	3	1016	c.750C>G	c.(748-750)GTC>GTG	p.V250V	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Silent_p.V277V|MUC15_uc001mqy.2_Intron	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	250	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TAAGCAATGAGACACCCAGAA	0.343													0	0	0	0.002096	0	26	63										C	26584757	G	C	26584757	2	2	96	1	0	0	0	0	0	0	0	1	9972	929	33	1		1	MUC15	11	26584757	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8275595	26584757	108421759	547	29023										
CCDC73	493860	broad.mit.edu	37	chr11	32636042	32636042	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcatgttctcgagtccctgGaagcaatctgaattgtttga	10	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:32636042G>T	uc001mtv.2	-	16	1866	c.1822C>A	c.(1822-1824)CCA>ACA	p.P608T		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	608										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					CGAGTCCCTGGAAGCAATCTG	0.333													1	0	8.12818e-05	0.001984	9.68923e-05	7	36										T	32636042	G	T	32636042	3	4	96	1	0	0	0	0	1	0	0	0	2846	1174	41	3	1429	3	CCDC73	11	32636042	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6051285	32636042	102370474	548	29024										
QSER1	79832	broad.mit.edu	37	chr11	32955538	32955538	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaagcaatggtgatcattctCagcagcaactccatcctcaa	6	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:32955538C>T	uc001mty.2	+	4	2614	c.2347C>T	c.(2347-2349)CAG>TAG	p.Q783*	QSER1_uc001mtz.1_Nonsense_Mutation_p.Q544*|QSER1_uc001mua.2_Nonsense_Mutation_p.Q288*	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	783	Gln-rich.							p.Q783Q(1)		ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TGATCATTCTCAGCAGCAACT	0.403													0	0	0	0.004007	0	16	104										T	32955538	C	T	32955538	4	4	96	1	0	0	0	0	0	1	0	0	12882	827	29	1	2353	1	QSER1	11	32955538	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	319496	32955538	102050978	549	29025										
CSTF3	1479	broad.mit.edu	37	chr11	33108639	33108639	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aacaggcactatagaaggagCtacaactgggtccggaatta	11	8	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:33108639C>A	uc001muh.2	-	18	1856	c.1690G>T	c.(1690-1692)GCT>TCT	p.A564S	TCP11L1_uc001muf.1_Intron	NM_001326	NP_001317	Q12996	CSTF3_HUMAN	cleavage stimulation factor subunit 3 isoform 1	564	Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0						ATAGAAGGAGCTACAACTGGG	0.433													1	0	1.5842e-08	0.001855	1.93326e-08	11	337										A	33108639	C	A	33108639	3	1	96	1	0	0	0	0	1	0	0	0	3986	797	28	4	479	4	CSTF3	11	33108639	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	153101	33108639	101897877	550	29026										
CRY2	1408	broad.mit.edu	37	chr11	45891150	45891150	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctaccaacaaccccaggtttGaccgcatggaggggaacccc	10	15	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:45891150G>C	uc010rgn.1	+	7	1061	c.1039G>C	c.(1039-1041)GAC>CAC	p.D347H	CRY2_uc009ykw.2_Missense_Mutation_p.D265H|CRY2_uc010rgo.1_Missense_Mutation_p.D69H	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	326	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						CCCCAGGTTTGACCGCATGGA	0.592													0	0	0	0.007835	0	42	100										C	45891150	G	C	45891150	3	2	96	1	0	0	0	0	1	0	0	0	3904	1290	45	1	1101	1	CRY2	11	45891150	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	12782511	45891150	89115366	551	29027										
DGKZ	8525	broad.mit.edu	37	chr11	46387826	46387826	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catggagactttctttaggaGacatttccgggggaaggtgc	14	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:46387826G>A	uc001ncn.1	+	2	145	c.20G>A	c.(19-21)AGA>AAA	p.R7K	DGKZ_uc001nch.1_Intron|DGKZ_uc010rgq.1_Intron|DGKZ_uc001ncj.1_Intron|DGKZ_uc010rgr.1_Intron|DGKZ_uc001nck.1_Intron|DGKZ_uc001ncl.2_Intron|DGKZ_uc001ncm.2_Intron|DGKZ_uc009yky.1_Intron|DGKZ_uc010rgs.1_Intron|DGKZ_uc001nci.1_Intron	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	7					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TTCTTTAGGAGACATTTCCGG	0.682													0	0	0	0.001984	0	7	19										A	46387826	G	A	46387826	3	1	96	1	0	0	0	0	1	0	0	0	4474	942	33	1	466	1	DGKZ	11	46387826	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	496676	46387826	88618690	552	29028										
DGKZ	8525	broad.mit.edu	37	chr11	46397143	46397143	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaccaggccaccatggtgcaGaaggccaagcggcggagcgc	15	13	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:46397143G>A	uc001ncn.1	+	21	2561	c.2436G>A	c.(2434-2436)CAG>CAA	p.Q812Q	DGKZ_uc001nch.1_Silent_p.Q640Q|DGKZ_uc010rgq.1_Silent_p.Q567Q|DGKZ_uc001ncj.1_Silent_p.Q590Q|DGKZ_uc010rgr.1_Silent_p.Q589Q|DGKZ_uc001nck.1_Silent_p.Q402Q|DGKZ_uc001ncl.2_Silent_p.Q624Q|DGKZ_uc001ncm.2_Silent_p.Q623Q|DGKZ_uc009yky.1_Silent_p.Q624Q|DGKZ_uc010rgs.1_Silent_p.Q601Q	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	812					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CCATGGTGCAGAAGGCCAAGC	0.507													0	0	0	0.004482	0	5	12										A	46397143	G	A	46397143	2	1	96	1	0	0	0	0	0	0	0	1	4474	933	33	1		1	DGKZ	11	46397143	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9317	46397143	88609373	553	29029										
ARFGAP2	84364	broad.mit.edu	37	chr11	47198344	47198344	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcacgcaccttgttggttgGaactgcgcgaagcctcttaa	10	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47198344G>C	uc001ndt.2	-	1	76	c.61C>G	c.(61-63)CCA>GCA	p.P21A	ARFGAP2_uc010rha.1_5'Flank|ARFGAP2_uc010rhb.1_Missense_Mutation_p.P21A|ARFGAP2_uc001ndu.2_Missense_Mutation_p.P21A|ARFGAP2_uc010rhc.1_5'UTR|ARFGAP2_uc010rhd.1_Missense_Mutation_p.P21A|ARFGAP2_uc001ndv.1_Missense_Mutation_p.P21A	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating	21	Arf-GAP.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TTGTTGGTTGGAACTGCGCGA	0.617													0	0	0	0.004482	0	8	44										C	47198344	G	C	47198344	3	2	96	1	0	0	0	0	1	0	0	0	850	1174	41	1	1568	1	ARFGAP2	11	47198344	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	801201	47198344	87808172	554	29030										
DDB2	1643	broad.mit.edu	37	chr11	47254407	47254407	+	Missense_Mutation	SNP	C	C	T													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgggctgaagtttaaccctCtcaataccaaccagttttac							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47254407C>T	uc001neb.2	+	4	694	c.499C>T	c.(499-501)CTC>TTC	p.L167F	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.L103F|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Missense_Mutation_p.L31F|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	167	WD 2.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						GTTTAACCCTCTCAATACCAA	0.498			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.000978	0	10	112										T	47254407	C	T	47254407	3	4	96	1	0	0	0	0	1	0	0	0	4324	913	32	1	513	1	DDB2	11	47254407	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	56063	47254407	87752109	555	29031	145	2								
DDB2	1643	broad.mit.edu	37	chr11	47254409	47254409	+	Silent	SNP	C	C	T													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggctgaagtttaaccctctCaataccaaccagttttacgc							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47254409C>T	uc001neb.2	+	4	696	c.501C>T	c.(499-501)CTC>CTT	p.L167L	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Silent_p.L103L|DDB2_uc001ned.2_Intron|DDB2_uc001nee.2_Intron|DDB2_uc001nef.2_Intron|DDB2_uc001neg.2_Silent_p.L31L|DDB2_uc001neh.2_RNA	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	167	WD 2.				nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TTAACCCTCTCAATACCAACC	0.498			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.000978	0	10	112										T	47254409	C	T	47254409	2	4	96	1	0	0	0	0	0	0	0	1	4324	813	29	1		1	DDB2	11	47254409	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2	47254409	87752107	556	29032	145	2								
FNBP4	23360	broad.mit.edu	37	chr11	47744605	47744605	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtggaggaggaggaggagGaggtggtggtggtggttcta	24	1	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:47744605G>C	uc009ylv.2	-	15	2881	c.2728C>G	c.(2728-2730)CCT>GCT	p.P910A	FNBP4_uc001ngi.2_Missense_Mutation_p.P224A|FNBP4_uc001ngj.2_Missense_Mutation_p.P817A	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	910	Pro-rich.									ovary(1)	1						ggaggaggaggaggtggtggt	0.353													0	0	0	0.001168	0	6	6										C	47744605	G	C	47744605	3	2	96	1	0	0	0	0	1	0	0	0	5967	1174	41	1	337	1	FNBP4	11	47744605	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	490196	47744605	87261911	557	29033										
PTPRJ	5795	broad.mit.edu	37	chr11	48152048	48152048	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacttccgagtgacagtggtCagcacgacggagatcggctt	14	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:48152048C>T	uc001ngp.3	+	8	1750	c.1395C>T	c.(1393-1395)GTC>GTT	p.V465V	PTPRJ_uc001ngo.3_Silent_p.V465V	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	465	Extracellular (Potential).|Fibronectin type-III 5.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						TGACAGTGGTCAGCACGACGG	0.468													0	0	0	0.004007	0	16	44										T	48152048	C	T	48152048	2	4	96	1	0	0	0	0	0	0	0	1	12804	813	29	1		1	PTPRJ	11	48152048	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	407443	48152048	86854468	558	29034										
OR5L2	26338	broad.mit.edu	37	chr11	55595152	55595152	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgctgctacttctgtgggaCggtgtgttctctgattcact	11	9	3	1	rs144590289	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:55595152C>T	uc001nhy.1	+	1	458	c.458C>T	c.(457-459)ACG>ATG	p.T153M		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				TTCTGTGGGACGGTGTGTTCT	0.488										HNSCC(27;0.073)			0	0	0	0.004878	0	35	127										T	55595152	C	T	55595152	3	4	96	1	0	0	0	0	1	0	0	0	11171	536	19	2	460	2	OR5L2	11	55595152	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7443104	55595152	79411364	559	29035										
OR5T3	390154	broad.mit.edu	37	chr11	56020545	56020545	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaattctcgtcagttatatGagaccaagttccagctatgc	7	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:56020545G>A	uc010rjd.1	+	1	870	c.870G>A	c.(868-870)ATG>ATA	p.M290I		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	290	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TCAGTTATATGAGACCAAGTT	0.403													0	0	0	0.000978	0	11	96										A	56020545	G	A	56020545	3	1	96	1	0	0	0	0	1	0	0	0	11183	1290	45	1	872	1	OR5T3	11	56020545	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	425393	56020545	78985971	560	29036										
OR5T1	390155	broad.mit.edu	37	chr11	56043552	56043552	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaccctctcctgtattcagtGagcatgtcacccagagtcta	7	13	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:56043552G>A	uc001nio.1	+	1	438	c.438G>A	c.(436-438)GTG>GTA	p.V146V		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	146	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TGTATTCAGTGAGCATGTCAC	0.438													0	0	0	0.00361	0	64	200										A	56043552	G	A	56043552	2	1	96	1	0	0	0	0	0	0	0	1	11181	1277	45	1		1	OR5T1	11	56043552	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	23007	56043552	78962964	561	29037										
OR8K1	390157	broad.mit.edu	37	chr11	56114212	56114212	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tattctagtggccattctcaGaatgaactcaaggaaaggga	10	7	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:56114212G>C	uc010rjg.1	+	1	698	c.698G>C	c.(697-699)AGA>ACA	p.R233T		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GCCATTCTCAGAATGAACTCA	0.378										HNSCC(65;0.19)			0	0	0	0.001368	0	13	53										C	56114212	G	C	56114212	3	2	96	1	0	0	0	0	1	0	0	0	11243	942	33	1	700	1	OR8K1	11	56114212	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	70660	56114212	78892304	562	29038										
OR5A2	219981	broad.mit.edu	37	chr11	59190117	59190117	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagccccatcccacagaagaCaaagtactgagtggcacagc	9	14	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:59190117C>A	uc010rkt.1	-	1	310	c.310G>T	c.(310-312)GTC>TTC	p.V104F		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCACAGAAGACAAAGTACTGA	0.507													1	0	2.37509e-13	0.001523	2.96629e-13	21	56										A	59190117	C	A	59190117	3	1	96	1	0	0	0	0	1	0	0	0	11140	478	17	4	666	4	OR5A2	11	59190117	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3075905	59190117	75816399	563	29039										
OR4D11	219986	broad.mit.edu	37	chr11	59271544	59271544	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agatctccctgttgctgcctCtccctttctgtggacccaat	7	15	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:59271544C>T	uc001noa.1	+	1	496	c.496C>T	c.(496-498)CTC>TTC	p.L166F		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTTGCTGCCTCTCCCTTTCTG	0.517													0	0	0	0.00361	0	54	172										T	59271544	C	T	59271544	3	4	96	1	0	0	0	0	1	0	0	0	11055	913	32	1	498	1	OR4D11	11	59271544	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	81427	59271544	75734972	564	29040										
OR4D11	219986	broad.mit.edu	37	chr11	59271963	59271963	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaagactgaagagaagactCgtgccttctgaaagggaata	12	6	1	6			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:59271963C>T	uc001noa.1	+	1	915	c.915C>T	c.(913-915)CTC>CTT	p.L305L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGAGAAGACTCGTGCCTTCTG	0.308													0	0	0	0.008291	0	11	53										T	59271963	C	T	59271963	2	4	96	1	0	0	0	0	0	0	0	1	11055	871	31	1		1	OR4D11	11	59271963	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	419	59271963	75734553	565	29041										
FTH1	2495	broad.mit.edu	37	chr11	61732243	61732243	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagggtgtgcttgtcaaagaGatattccgccaagccagatt	11	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:61732243G>C	uc001nsu.2	-	4	743	c.508C>G	c.(508-510)CTC>GTC	p.L170V		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	170					cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	TTGTCAAAGAGATATTCCGCC	0.522													0	0	0	0.003954	0	24	70										C	61732243	G	C	61732243	3	2	96	1	0	0	0	0	1	0	0	0	6082	942	33	1	47	1	FTH1	11	61732243	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2460280	61732243	73274273	566	29042										
FTH1	2495	broad.mit.edu	37	chr11	61732561	61732561	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccattgcattcagcccgctCtcccagtcatcacagtctgg	7	16	5	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:61732561C>G	uc001nsu.2	-	3	520	c.285G>C	c.(283-285)GAG>GAC	p.E95D		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	95	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	TCAGCCCGCTCTCCCAGTCAT	0.448													0	0	0	0.002836	0	33	221										G	61732561	C	G	61732561	3	3	96	1	0	0	0	0	1	0	0	0	6082	912	32	1	274	1	FTH1	11	61732561	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	318	61732561	73273955	567	29043										
FTH1	2495	broad.mit.edu	37	chr11	61732918	61732918	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcagcatgttccctctcctCatgagattggtgaagaaagt	9	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:61732918C>G	uc001nsu.2	-	2	419	c.184G>C	c.(184-186)GAG>CAG	p.E62Q		NM_002032	NP_002023	P02794	FRIH_HUMAN	ferritin, heavy polypeptide 1	62	Ferritin-like diiron.				cell proliferation|cellular membrane organization|immune response|intracellular sequestering of iron ion|iron ion transport|negative regulation of cell proliferation|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|ferroxidase activity|protein binding			ovary(1)	1					Iron Dextran(DB00893)	TCCCTCTCCTCATGAGATTGG	0.443													0	0	0	0.008361	0	30	212										G	61732918	C	G	61732918	3	3	96	1	0	0	0	0	1	0	0	0	6082	835	29	1	379	1	FTH1	11	61732918	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	357	61732918	73273598	568	29044										
AHNAK	79026	broad.mit.edu	37	chr11	62289440	62289440	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgccttccactttgggcagaGaaacgtccacgtcgcccttc	9	16	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62289440G>A	uc001ntl.2	-	5	12749	c.12449C>T	c.(12448-12450)TCT>TTT	p.S4150F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4150					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTTGGGCAGAGAAACGTCCAC	0.522													0	0	0	0.00874	0	45	132										A	62289440	G	A	62289440	3	1	96	1	0	0	0	0	1	0	0	0	414	942	33	1	5343	1	AHNAK	11	62289440	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	556522	62289440	72717076	569	29045										
INTS5	80789	broad.mit.edu	37	chr11	62414702	62414702	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcaagggcccatgctcccgGagaaaaccccagacactgag	12	14	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62414702G>C	uc001nud.2	-	2	2903	c.2850C>G	c.(2848-2850)CTC>CTG	p.L950L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	950	Helical; (Potential).				snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CATGCTCCCGGAGAAAACCCC	0.587													0	0	0	0.00361	0	49	198										C	62414702	G	C	62414702	2	2	96	1	0	0	0	0	0	0	0	1	7781	1161	41	1		1	INTS5	11	62414702	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	125262	62414702	72591814	570	29046										
INTS5	80789	broad.mit.edu	37	chr11	62415293	62415293	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggctttaagccacggccgatGactccagcatggaaaactga	11	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62415293G>A	uc001nud.2	-	2	2312	c.2259C>T	c.(2257-2259)GTC>GTT	p.V753V	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	753					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CACGGCCGATGACTCCAGCAT	0.547													0	0	0	0.006122	0	17	62										A	62415293	G	A	62415293	2	1	96	1	0	0	0	0	0	0	0	1	7781	1277	45	1		1	INTS5	11	62415293	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	591	62415293	72591223	571	29047										
HNRNPUL2	221092	broad.mit.edu	37	chr11	62494157	62494157	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcgtccccgctccgctcctCgggttcgtcttcctccctct	7	21	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:62494157C>G	uc001nuw.2	-	1	665	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	HNRNPUL2_uc001nuu.1_RNA|TTC9C_uc001nux.2_5'Flank|TTC9C_uc001nuy.2_5'Flank	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	158	Glu-rich.				cell killing	nucleus	ATP binding|nucleic acid binding				0						CTCCGCTCCTCGGGTTCGTCT	0.701													0	0	0	0.001368	0	13	26										G	62494157	C	G	62494157	3	3	96	1	0	0	0	0	1	0	0	0	7275	893	31	1	1827	1	HNRNPUL2	11	62494157	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	78864	62494157	72512359	572	29048										
NRXN2	9379	broad.mit.edu	37	chr11	64410027	64410027	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttaccgtggccgccgcgggtGaggaagggcatgcggttgat	18	9	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64410027G>A	uc001oap.2	-	2	760	c.249C>T	c.(247-249)CTC>CTT	p.L83L	NRXN2_uc001oar.2_Intron|NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_Intron	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	83	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CGCCGCGGGTGAGGAAGGGCA	0.731													0	0	0	0.00308	0	7	18										A	64410027	G	A	64410027	2	1	96	1	0	0	0	0	0	0	0	1	10666	1277	45	1		1	NRXN2	11	64410027	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1915870	64410027	70596489	573	29049										
PYGM	5837	broad.mit.edu	37	chr11	64520647	64520647	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttatgaggctccagctcataGaagtctttgaagctgcagga	11	8	2	3	rs142207594		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64520647G>C	uc001oax.3	-	12	2233	c.1416C>G	c.(1414-1416)TTC>TTG	p.F472L	PYGM_uc001oay.3_Missense_Mutation_p.F384L	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	472					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CCAGCTCATAGAAGTCTTTGA	0.577													0	0	0	0.00361	0	62	146										C	64520647	G	C	64520647	3	2	96	1	0	0	0	0	1	0	0	0	12862	933	33	1	1148	1	PYGM	11	64520647	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	110620	64520647	70485869	574	29050										
ATG2A	23130	broad.mit.edu	37	chr11	64665196	64665196	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atccagccagatggggacctCagacgtgaagcggaactctc	12	12	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64665196C>T	uc001obx.2	-	36	5129	c.5014G>A	c.(5014-5016)GAG>AAG	p.E1672K	ATG2A_uc001obw.2_Missense_Mutation_p.E437K	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1672							protein binding			ovary(1)|central_nervous_system(1)	2						ATGGGGACCTCAGACGTGAAG	0.647													0	0	0	0.001368	0	12	48										T	64665196	C	T	64665196	3	4	96	1	0	0	0	0	1	0	0	0	1093	835	29	1	826	1	ATG2A	11	64665196	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	144549	64665196	70341320	575	29051										
ZNHIT2	741	broad.mit.edu	37	chr11	64884581	64884581	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcaggcccccgggacatctCcaagaacccgctcggcggcc	12	18	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:64884581C>T	uc001ocw.2	-	1	590	c.545G>A	c.(544-546)GGA>GAA	p.G182E	uc009yqb.1_Missense_Mutation_p.S151F	NM_014205	NP_055020	Q9UHR6	ZNHI2_HUMAN	zinc finger, HIT domain containing 2	182							metal ion binding			breast(1)	1						CGGGACATCTCCAAGAACCCG	0.726													0	0	0	0.001984	0	5	14										T	64884581	C	T	64884581	3	4	96	1	0	0	0	0	1	0	0	0	18204	855	30	1	670	1	ZNHIT2	11	64884581	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	219385	64884581	70121935	576	29052										
RELA	5970	broad.mit.edu	37	chr11	65427190	65427190	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaggcggaggggcctgcctGatgggtcccgcactgtcacc	16	14	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:65427190G>C	uc001ofg.2	-	6	646	c.506C>G	c.(505-507)TCA>TGA	p.S169*	RELA_uc001ofh.2_Nonsense_Mutation_p.S166*|RELA_uc010ron.1_Nonsense_Mutation_p.S180*|RELA_uc009yqr.2_Nonsense_Mutation_p.S116*|RELA_uc001ofe.2_Nonsense_Mutation_p.S169*|RELA_uc001off.2_Nonsense_Mutation_p.S169*|RELA_uc009yqs.1_RNA	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	169	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4						GGGCCTGCCTGATGGGTCCCG	0.587													0	0	0	0.007291	0	26	74										C	65427190	G	C	65427190	4	2	96	1	0	0	0	0	0	1	0	0	13216	1294	45	1	1173	1	RELA	11	65427190	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	542609	65427190	69579326	577	29053										
BBS1	582	broad.mit.edu	37	chr11	66278173	66278173	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attccgacgcctgcggagctGagaggtgaaggcagggctcc	16	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:66278173G>A	uc001oij.1	+	1	55	c.43G>A	c.(43-45)GAG>AAG	p.E15K	BBS1_uc001oii.1_Intron|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Missense_Mutation_p.E15K|BBS1_uc001oik.1_5'UTR|BBS1_uc001oil.1_Missense_Mutation_p.E15K	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	15					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						CTGCGGAGCTGAGAGGTGAAG	0.662									Bardet-Biedl_syndrome				0	0	0	0.008291	0	9	32										A	66278173	G	A	66278173	3	1	96	1	0	0	0	0	1	0	0	0	1335	1291	45	1	45	1	BBS1	11	66278173	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	850983	66278173	68728343	578	29054										
KDM2A	22992	broad.mit.edu	37	chr11	67022406	67022406	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgcattgccaacgtcaccttGatcgaccttcgaggatgcaa	9	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:67022406G>A	uc001ojw.2	+	21	4233	c.3369G>A	c.(3367-3369)TTG>TTA	p.L1123L	KDM2A_uc001ojx.2_RNA|KDM2A_uc001ojy.2_Silent_p.L817L|KDM2A_uc001ojz.1_3'UTR|KDM2A_uc001oka.2_Silent_p.L247L	NM_012308	NP_036440	Q9Y2K7	KDM2A_HUMAN	F-box and leucine-rich repeat protein 11	1123	LRR 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9						ACGTCACCTTGATCGACCTTC	0.502													0	0	0	0.001984	0	6	19										A	67022406	G	A	67022406	2	1	96	1	0	0	0	0	0	0	0	1	8124	1281	45	1		1	KDM2A	11	67022406	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	744233	67022406	67984110	579	29055										
CHKA	1119	broad.mit.edu	37	chr11	67888317	67888317	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatgacactgatgtggaactCgtcctcgcggaggccccgcc	13	14	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:67888317C>T	uc001onj.2	-	1	542	c.328G>A	c.(328-330)GAG>AAG	p.E110K	CHKA_uc001onk.2_Missense_Mutation_p.E110K	NM_001277	NP_001268	P35790	CHKA_HUMAN	choline kinase alpha isoform a	110					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)	ATGTGGAACTCGTCCTCGCGG	0.577													0	0	0	0.004007	0	13	47										T	67888317	C	T	67888317	3	4	96	1	0	0	0	0	1	0	0	0	3347	893	31	1	1093	1	CHKA	11	67888317	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	865911	67888317	67118199	580	29056										
PPFIA1	8500	broad.mit.edu	37	chr11	70189871	70189871	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagtgatgctgacgtgtctGatggtgaagatgacagggac	16	5	1	7			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:70189871G>C	uc001opo.2	+	15	2002	c.1804G>C	c.(1804-1806)GAT>CAT	p.D602H	PPFIA1_uc001opn.1_Missense_Mutation_p.D602H|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	602					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGACGTGTCTGATGGTGAAGA	0.532													0	0	0	0.001984	0	7	58										C	70189871	G	C	70189871	3	2	96	1	0	0	0	0	1	0	0	0	12309	1290	45	1	1858	1	PPFIA1	11	70189871	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2301554	70189871	64816645	581	29057										
ARHGEF17	9828	broad.mit.edu	37	chr11	73078785	73078785	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagcagtgagactgtgggtcGagacgacagcacaaaccacc	12	12	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73078785G>A	uc001otu.2	+	21	6173	c.6152G>A	c.(6151-6153)CGA>CAA	p.R2051Q		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	2051					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						ACTGTGGGTCGAGACGACAGC	0.632													0	0	0	0.004007	0	13	82										A	73078785	G	A	73078785	3	1	96	1	0	0	0	0	1	0	0	0	900	1058	37	1	6234	1	ARHGEF17	11	73078785	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2888914	73078785	61927731	582	29058										
UCP3	7352	broad.mit.edu	37	chr11	73718076	73718076	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaggcacgtctgaaggcttCagtccaaccatagtcctgga	12	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73718076C>T	uc001our.2	-	2	367	c.12G>A	c.(10-12)CTG>CTA	p.L4L	UCP3_uc001ous.2_Silent_p.L4L	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	4					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					CTGAAGGCTTCAGTCCAACCA	0.602													0	0	0	0.000978	0	9	31										T	73718076	C	T	73718076	2	4	96	1	0	0	0	0	0	0	0	1	16929	813	29	1		1	UCP3	11	73718076	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	639291	73718076	61288440	583	29059										
C2CD3	26005	broad.mit.edu	37	chr11	73820130	73820130	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggaaagtgaggttggaattCcaccagtgctctatcattgg	12	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73820130C>A	uc001ouu.2	-	12	2138	c.1911G>T	c.(1909-1911)TGG>TGT	p.W637C		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	637						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GGTTGGAATTCCACCAGTGCT	0.433													1	0	7.07596e-05	0.006122	8.44891e-05	19	47										A	73820130	C	A	73820130	3	1	96	1	0	0	0	0	1	0	0	0	2154	856	30	3	4060	3	C2CD3	11	73820130	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	102054	73820130	61186386	584	29060										
C2CD3	26005	broad.mit.edu	37	chr11	73844510	73844510	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcttcattaataggaggatGaacttggtccaacaacatgc	8	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:73844510G>A	uc001ouu.2	-	6	1275	c.1048C>T	c.(1048-1050)CAT>TAT	p.H350Y	C2CD3_uc001ouv.2_Missense_Mutation_p.H350Y	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	350						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ATAGGAGGATGAACTTGGTCC	0.393													0	0	0	0.00245	0	13	20										A	73844510	G	A	73844510	3	1	96	1	0	0	0	0	1	0	0	0	2154	1290	45	1	4947	1	C2CD3	11	73844510	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	24380	73844510	61162006	585	29061										
MAP6	4135	broad.mit.edu	37	chr11	75298605	75298605	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccatggcactttcatccttCggatgctctgggaccatggg	12	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:75298605C>T	uc001owu.2	-	4	2006	c.1941G>A	c.(1939-1941)CCG>CCA	p.P647P		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	647	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TTTCATCCTTCGGATGCTCTG	0.512													0	0	0	0.00361	0	58	129										T	75298605	C	T	75298605	2	4	96	1	0	0	0	0	0	0	0	1	9264	871	31	1		1	MAP6	11	75298605	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1454095	75298605	59707911	586	29062										
C11orf30	56946	broad.mit.edu	37	chr11	76257029	76257029	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacattttgaaaatgtctttGatggaagctcagattgatac	9	5	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:76257029G>C	uc001oxl.2	+	20	3605	c.3462G>C	c.(3460-3462)TTG>TTC	p.L1154F	C11orf30_uc001oxm.2_Missense_Mutation_p.L1056F|C11orf30_uc010rsb.1_Missense_Mutation_p.L1169F|C11orf30_uc010rsc.1_Missense_Mutation_p.L1155F|C11orf30_uc001oxn.2_Missense_Mutation_p.L1155F|C11orf30_uc010rsd.1_Missense_Mutation_p.L1063F|C11orf30_uc010rse.1_Missense_Mutation_p.L401F|C11orf30_uc001oxp.2_Intron	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1154					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						AAATGTCTTTGATGGAAGCTC	0.448													0	0	0	0.00333	0	26	59										C	76257029	G	C	76257029	3	2	96	1	0	0	0	0	1	0	0	0	1636	1281	45	1	3536	1	C11orf30	11	76257029	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	958424	76257029	58749487	587	29063										
ODZ4	26011	broad.mit.edu	37	chr11	78369325	78369325	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacgcttggcgcacggctctCtgccgggccagctccaggac	13	17	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:78369325C>G	uc001ozl.3	-	34	8551	c.8088G>C	c.(8086-8088)CAG>CAC	p.Q2696H	ODZ4_uc001ozk.3_Missense_Mutation_p.Q921H|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2696	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GCACGGCTCTCTGCCGGGCCA	0.657													0	0	0	0.008291	0	10	21										G	78369325	C	G	78369325	3	3	96	1	0	0	0	0	1	0	0	0	10837	912	32	1	225	1	ODZ4	11	78369325	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2112296	78369325	56637191	588	29064										
CCDC81	60494	broad.mit.edu	37	chr11	86119250	86119250	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaaggaggagagagatagaaGatgagagactcatacagcag	14	4	1	6			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:86119250G>A	uc001pbx.1	+	9	1479	c.1051G>A	c.(1051-1053)GAT>AAT	p.D351N	CCDC81_uc001pbw.1_Missense_Mutation_p.D261N|CCDC81_uc010rtq.1_Missense_Mutation_p.D134N|CCDC81_uc001pby.1_Intron	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	351										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				AGAGATAGAAGATGAGAGACT	0.428													0	0	0	0.000978	0	11	35										A	86119250	G	A	86119250	3	1	96	1	0	0	0	0	1	0	0	0	2855	942	33	1	1085	1	CCDC81	11	86119250	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7749925	86119250	48887266	589	29065										
KBTBD3	143879	broad.mit.edu	37	chr11	105923824	105923824	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caaaagatccttcgcctttcCaaacacaagtgtctggacaa	6	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:105923824C>G	uc001pja.2	-	4	2232	c.1592G>C	c.(1591-1593)TGG>TCG	p.W531S	KBTBD3_uc001pjb.2_Missense_Mutation_p.W531S|KBTBD3_uc009yxm.2_Missense_Mutation_p.W452S	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	527										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TTCGCCTTTCCAAACACAAGT	0.358													0	0	0	0.000602	0	5	46										G	105923824	C	G	105923824	3	3	96	1	0	0	0	0	1	0	0	0	7994	595	21	4	250	4	KBTBD3	11	105923824	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	19804574	105923824	29082692	590	29066										
DDX10	1662	broad.mit.edu	37	chr11	108577549	108577549	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcttcttcagaagaaagtacCtgtgaaggaaatcaagtaag	10	6	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:108577549C>T	uc001pkm.2	+	10	1372	c.1307C>T	c.(1306-1308)CCT>CTT	p.P436L	DDX10_uc001pkl.1_Missense_Mutation_p.P436L	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	436	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AAGAAAGTACCTGTGAAGGAA	0.373			T	NUP98	AML*								0	0	0	0.005443	0	27	154										T	108577549	C	T	108577549	3	4	96	1	0	0	0	0	1	0	0	0	4342	681	24	2	1345	2	DDX10	11	108577549	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2653725	108577549	26428967	591	29067										
ZBTB16	7704	broad.mit.edu	37	chr11	113934854	113934854	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggttgaggaaagaggcaaaGaggggcctgggaccccgact	17	8	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:113934854G>C	uc001pop.2	+	2	1096	c.832G>C	c.(832-834)GAG>CAG	p.E278Q	ZBTB16_uc001poo.1_Missense_Mutation_p.E278Q|ZBTB16_uc001poq.2_Missense_Mutation_p.E278Q	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	278					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AAGAGGCAAAGAGGGGCCTGG	0.632													0	0	0	0.004482	0	8	41										C	113934854	G	C	113934854	3	2	96	1	0	0	0	0	1	0	0	0	17523	943	33	1	834	1	ZBTB16	11	113934854	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5357305	113934854	21071662	592	29068										
ABCG4	64137	broad.mit.edu	37	chr11	119027643	119027643	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgttgttcagggctgtgcaGaatgggctgtgcgctatggc	16	7	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:119027643G>C	uc001pvs.2	+	9	1323	c.987G>C	c.(985-987)CAG>CAC	p.Q329H	ABCG4_uc009zar.2_Missense_Mutation_p.Q329H	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	329	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGGCTGTGCAGAATGGGCTGT	0.582													0	0	0	0.00278	0	22	98										C	119027643	G	C	119027643	3	2	96	1	0	0	0	0	1	0	0	0	70	933	33	1	1017	1	ABCG4	11	119027643	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5092789	119027643	15978873	593	29069										
POU2F3	25833	broad.mit.edu	37	chr11	120169015	120169015	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gactccctgcagcagaccctCtcccatcggccatgccacct	7	20	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:120169015C>T	uc001pxc.2	+	4	276	c.174C>T	c.(172-174)CTC>CTT	p.L58L	POU2F3_uc010rzk.1_5'UTR|POU2F3_uc010rzl.1_5'UTR	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	58					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		AGCAGACCCTCTCCCATCGGC	0.532													0	0	0	0.002522	0	43	227										T	120169015	C	T	120169015	2	4	96	1	0	0	0	0	0	0	0	1	12273	900	32	1		1	POU2F3	11	120169015	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1141372	120169015	14837501	594	29070										
C11orf63	79864	broad.mit.edu	37	chr11	122805334	122805334	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggaaccagaataaccctccCaggcagcaacaaaaccaaaa	7	13	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:122805334C>T	uc001pym.2	+	5	1482	c.1185C>T	c.(1183-1185)CCC>CCT	p.P395P		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	395										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		ATAACCCTCCCAGGCAGCAAC	0.463													0	0	0	0.00308	0	8	32										T	122805334	C	T	122805334	2	4	96	1	0	0	0	0	0	0	0	1	1654	581	21	2		2	C11orf63	11	122805334	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2636319	122805334	12201182	595	29071										
ST14	6768	broad.mit.edu	37	chr11	130059777	130059777	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagtcctttgtggtcacctCagtggtggctttccgtgagt	13	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr11:130059777C>T	uc001qfw.2	+	5	777	c.584C>T	c.(583-585)TCA>TTA	p.S195L	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	195	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GTGGTCACCTCAGTGGTGGCT	0.701													0	0	0	0.008871	0	18	85										T	130059777	C	T	130059777	3	4	96	1	0	0	0	0	1	0	0	0	15210	838	29	1	602	1	ST14	11	130059777	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7254443	130059777	4946739	596	29072										
CACNA1C	775	broad.mit.edu	37	chr12	2690861	2690861	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcatcatcatcttctccctCctggggatgcagctctttgg	8	13	6	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:2690861C>A	uc009zdu.1	+	14	2314	c.2001C>A	c.(1999-2001)CTC>CTA	p.L667L	CACNA1C_uc009zdv.1_Silent_p.L664L|CACNA1C_uc001qkb.2_Silent_p.L667L|CACNA1C_uc001qkc.2_Silent_p.L667L|CACNA1C_uc001qke.2_Silent_p.L667L|CACNA1C_uc001qkf.2_Silent_p.L667L|CACNA1C_uc001qjz.2_Silent_p.L667L|CACNA1C_uc001qkd.2_Silent_p.L667L|CACNA1C_uc001qkg.2_Silent_p.L667L|CACNA1C_uc009zdw.1_Silent_p.L667L|CACNA1C_uc001qkh.2_Silent_p.L667L|CACNA1C_uc001qkl.2_Silent_p.L667L|CACNA1C_uc001qkn.2_Silent_p.L667L|CACNA1C_uc001qko.2_Silent_p.L667L|CACNA1C_uc001qkp.2_Silent_p.L667L|CACNA1C_uc001qkr.2_Silent_p.L667L|CACNA1C_uc001qku.2_Silent_p.L667L|CACNA1C_uc001qkq.2_Silent_p.L667L|CACNA1C_uc001qks.2_Silent_p.L667L|CACNA1C_uc001qkt.2_Silent_p.L667L|CACNA1C_uc001qka.1_Silent_p.L202L|CACNA1C_uc001qki.1_Silent_p.L403L|CACNA1C_uc001qkj.1_Silent_p.L403L|CACNA1C_uc001qkk.1_Silent_p.L403L|CACNA1C_uc001qkm.1_Silent_p.L403L|CACNA1C_uc001qkw.2_5'Flank	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	667	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tcttctccctcctGGGGATGC	0.423													1	0	5.50884e-06	0.001368	6.64382e-06	12	86										A	2690861	C	A	2690861	2	1	96	1	0	0	0	0	0	0	0	1	2540	842	30	3		3	CACNA1C	12	2690861	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		2690861	131161034	597	29073										
ITFG2	55846	broad.mit.edu	37	chr12	2933049	2933049	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcggatggagtctaccaatCtggtgaaactgctggagacc	13	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:2933049C>T	uc001qlb.1	+	11	1244	c.1180C>T	c.(1180-1182)CTG>TTG	p.L394L	ITFG2_uc010seb.1_Silent_p.L217L|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	394											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GTCTACCAATCTGGTGAAACT	0.582													0	0	0	0.00361	0	43	97										T	2933049	C	T	2933049	2	4	96	1	0	0	0	0	0	0	0	1	7870	912	32	1		1	ITFG2	12	2933049	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	242188	2933049	130918846	598	29074										
CD4	920	broad.mit.edu	37	chr12	6924060	6924060	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagggggggaagaccctctCcgtgtctcagctggagctcc	14	13	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:6924060C>T	uc001qqv.1	+	5	754	c.509C>T	c.(508-510)TCC>TTC	p.S170F	CD4_uc009zez.1_Missense_Mutation_p.S115F|CD4_uc009zfa.1_RNA|CD4_uc009zfb.1_RNA|CD4_uc010sfj.1_5'UTR|CD4_uc009zfc.1_5'UTR|CD4_uc010sfk.1_5'UTR|CD4_uc010sfl.1_5'UTR|CD4_uc010sfm.1_5'UTR	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	170	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				AAGACCCTCTCCGTGTCTCAG	0.552													0	0	0	0.001882	0	22	49										T	6924060	C	T	6924060	3	4	96	1	0	0	0	0	1	0	0	0	3014	855	30	1	523	1	CD4	12	6924060	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3991011	6924060	126927835	599	29075										
CLEC6A	93978	broad.mit.edu	37	chr12	8618181	8618181	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagtgagcagaactgtgttGagatgggagcacatttggtt	15	4	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:8618181G>A	uc001qum.1	+	4	442	c.325G>A	c.(325-327)GAG>AAG	p.E109K		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	109	Extracellular (Potential).|C-type lectin.				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					GAACTGTGTTGAGATGGGAGC	0.363													0	0	0	0.003755	0	30	77										A	8618181	G	A	8618181	3	1	96	1	0	0	0	0	1	0	0	0	3520	1291	45	1	339	1	CLEC6A	12	8618181	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1694121	8618181	125233714	600	29076										
CLEC12A	160364	broad.mit.edu	37	chr12	10124258	10124258	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccagtgagatggaaaaaatCccagaaattggcaaatttgg	10	6	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:10124258C>T	uc001qwr.3	+	1	251	c.63C>T	c.(61-63)ATC>ATT	p.I21I	CLEC12A_uc001qwq.2_Silent_p.I31I|CLEC12A_uc001qws.3_Silent_p.I21I|CLEC12A_uc001qwt.2_5'UTR	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	21	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						TGGAAAAAATCCCAGAAATTG	0.318													0	0	0	0.00499	0	18	73										T	10124258	C	T	10124258	2	4	96	1	0	0	0	0	0	0	0	1	3497	845	30	1		1	CLEC12A	12	10124258	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1506077	10124258	123727637	601	29077										
BCL2L14	79370	broad.mit.edu	37	chr12	12247765	12247765	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atagacgtcacggccaagctCacagctattgacaaccaccc	7	15	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:12247765C>G	uc001rac.2	+	5	1047	c.846C>G	c.(844-846)CTC>CTG	p.L282L	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_Intron|BCL2L14_uc001rad.2_Silent_p.L282L|BCL2L14_uc001rae.2_3'UTR	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	282					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CGGCCAAGCTCACAGCTATTG	0.552													0	0	0	0.007291	0	31	91										G	12247765	C	G	12247765	2	3	96	1	0	0	0	0	0	0	0	1	1372	813	29	1		1	BCL2L14	12	12247765	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2123507	12247765	121604130	602	29078										
PLCZ1	89869	broad.mit.edu	37	chr12	18876389	18876389	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaatatgtgttgaaaatctCaataatttcttctctgtgcg	7	6	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:18876389C>T	uc010sid.1	-	4	414	c.223G>A	c.(223-225)GAG>AAG	p.E75K	PLCZ1_uc001rdv.3_5'UTR|PLCZ1_uc001rdw.3_Intron	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	75					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TTGAAAATCTCAATAATTTCT	0.338													0	0	0	0.004007	0	16	65										T	18876389	C	T	18876389	3	4	96	1	0	0	0	0	1	0	0	0	12044	835	29	1	1651	1	PLCZ1	12	18876389	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6628624	18876389	114975506	603	29079										
PDE3A	5139	broad.mit.edu	37	chr12	20801786	20801786	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaattttggccactgacctGaagaaacactttgacttcgt	8	10	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:20801786G>A	uc001reh.1	+	13	2752	c.2730G>A	c.(2728-2730)CTG>CTA	p.L910L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	910	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCACTGACCTGAAGAAACACT	0.323													0	0	0	0.003271	0	31	64										A	20801786	G	A	20801786	2	1	96	1	0	0	0	0	0	0	0	1	11637	1277	45	1		1	PDE3A	12	20801786	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1925397	20801786	113050109	604	29080										
C12orf71	728858	broad.mit.edu	37	chr12	27235150	27235150	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgtccacgtcccaggccagGaagatgcttagtttgcaaaa	10	10	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:27235150G>T	uc001rhq.2	-	1	306	c.267C>A	c.(265-267)TTC>TTA	p.F89L		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	89											0						CCCAGGCCAGGAAGATGCTTA	0.483													1	0	0.00307968	0.00308	0.00364399	7	52										T	27235150	G	T	27235150	3	4	96	1	0	0	0	0	1	0	0	0	1712	1165	41	3	550	3	C12orf71	12	27235150	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6433364	27235150	106616745	605	29081										
IPO8	10526	broad.mit.edu	37	chr12	30833556	30833556	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tattataagaggttctctctCttctgctttcttatatctac	4	9	5	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:30833556C>T	uc001rjd.2	-	5	669	c.499G>A	c.(499-501)GAG>AAG	p.E167K		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	167					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GGTTCTCTCTCTTCTGCTTTC	0.318													0	0	0	0.007413	0	19	136										T	30833556	C	T	30833556	3	4	96	1	0	0	0	0	1	0	0	0	7798	922	32	1	2698	1	IPO8	12	30833556	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3598406	30833556	103018339	606	29082										
KIF21A	55605	broad.mit.edu	37	chr12	39703448	39703448	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaccttaatataagatgttGatacagtgaagaccaaactg	7	7	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:39703448G>C	uc001rly.2	-	33	4363	c.4217C>G	c.(4216-4218)TCA>TGA	p.S1406*	KIF21A_uc001rlv.2_Nonsense_Mutation_p.S351*|KIF21A_uc001rlw.2_Nonsense_Mutation_p.S676*|KIF21A_uc001rlx.2_Nonsense_Mutation_p.S1393*|KIF21A_uc001rlz.2_Nonsense_Mutation_p.S1353*|KIF21A_uc010skl.1_Nonsense_Mutation_p.S1369*|KIF21A_uc001rlt.2_Nonsense_Mutation_p.S26*|KIF21A_uc001rlu.2_Nonsense_Mutation_p.S26*	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1406	WD 2.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				ATAAGATGTTGATACAGTGAA	0.393													0	0	0	0.001855	0	12	49										C	39703448	G	C	39703448	4	2	96	1	0	0	0	0	0	1	0	0	8288	1294	45	1	831	1	KIF21A	12	39703448	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8869892	39703448	94148447	607	29083										
LRRK2	120892	broad.mit.edu	37	chr12	40629491	40629491	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgtcagtgattggactgaaGaccttagatctcctcctaac	8	10	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:40629491G>A	uc001rmg.3	+	4	532	c.411G>A	c.(409-411)AAG>AAA	p.K137K		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	137					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGGACTGAAGACCTTAGATC	0.303													0	0	0	0.001855	0	12	53										A	40629491	G	A	40629491	2	1	96	1	0	0	0	0	0	0	0	1	9033	933	33	1		1	LRRK2	12	40629491	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	926043	40629491	93222404	608	29084										
ARID2	196528	broad.mit.edu	37	chr12	46240637	46240638	+	Splice_Site	INS	-	-	GCTT													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctaatgtatttttttctttaINSgcttccagagcagttgtagc							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			-	GCTT	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:46240637_46240638insGCTT	uc001ros.1	+	12	1499	c.1499_splice	c.e12-1	p.A500_splice	ARID2_uc001ror.2_Splice_Site_p.A500_splice|ARID2_uc009zkg.1_Splice_Site|ARID2_uc009zkh.1_Splice_Site_p.A127_splice	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTTTTCTTTAGCTTCCAGAGC	0.351																		8	70	---	---								GCTT	46240638	-	GCTT	46240637	8	5	96	1	0	1	1	0	0	0	1	0	915	434	15	0	1543	0	ARID2	12	46240637	Splice_Site	INS	-	TCGA-G2-A2EO-01A-11D-A17V-08	5611146	46240637	87611258	609	29085										
LASS5	91012	broad.mit.edu	37	chr12	50536906	50536906	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggcttgtcctgattcctccGatggcgaaaccagcattgga	12	11	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:50536906G>A	uc001rwd.3	-	3	402	c.385C>T	c.(385-387)CGG>TGG	p.R129W	LASS5_uc001rwc.2_Missense_Mutation_p.R48W|LASS5_uc001rwe.3_Missense_Mutation_p.R70W|LASS5_uc001rwf.3_RNA|LASS5_uc010smq.1_5'UTR	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	129	Cytoplasmic (Potential).|Homeobox.				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						TGATTCCTCCGATGGCGAAAC	0.478													0	0	0	0.00361	0	124	307										A	50536906	G	A	50536906	3	1	96	1	0	0	0	0	1	0	0	0	8642	1057	37	1	825	1	LASS5	12	50536906	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4296269	50536906	83314989	610	29086										
METTL7A	25840	broad.mit.edu	37	chr12	51323733	51323733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcatggagcatgtggcagctGagtgttcgacttggaattac	13	7	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51323733G>C	uc001rxb.2	+	2	823	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	METTL7A_uc010smv.1_Nonstop_Mutation_p.*110S	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	179						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						TGTGGCAGCTGAGTGTTCGAC	0.428													0	0	0	0.00361	0	56	188										C	51323733	G	C	51323733	3	2	96	1	0	0	0	0	1	0	0	0	9505	1291	45	1	541	1	METTL7A	12	51323733	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	786827	51323733	82528162	611	29087										
METTL7A	25840	broad.mit.edu	37	chr12	51323817	51323817	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgggtgcaacctgaccagaGagagctggaaggccctggag	16	9	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51323817G>T	uc001rxb.2	+	2	907	c.619G>T	c.(619-621)GAG>TAG	p.E207*	METTL7A_uc010smv.1_3'UTR	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	207						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						CCTGACCAGAGAGAGCTGGAA	0.572													1	0	3.33393e-15	0.004878	4.18558e-15	38	127										T	51323817	G	T	51323817	4	4	96	1	0	0	0	0	0	1	0	0	9505	943	33	3	625	3	METTL7A	12	51323817	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	84	51323817	82528078	612	29088										
CSRNP2	81566	broad.mit.edu	37	chr12	51467852	51467852	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgcagctgcttctgccgcttCaggatggatgtggctgagaa	14	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51467852C>T	uc001rxu.1	-	3	463	c.165G>A	c.(163-165)CTG>CTA	p.L55L		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	55					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTGCCGCTTCAGGATGGATG	0.383													0	0	0	0.00333	0	25	78										T	51467852	C	T	51467852	2	4	96	1	0	0	0	0	0	0	0	1	3964	813	29	1		1	CSRNP2	12	51467852	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	144035	51467852	82384043	613	29089										
BIN2	51411	broad.mit.edu	37	chr12	51686023	51686023	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttgctgagacagattcactCtcactcttcaaggaaagtgt	9	9	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:51686023C>G	uc001ryg.2	-	10	919	c.867G>C	c.(865-867)GAG>GAC	p.E289D	BIN2_uc009zlz.2_Missense_Mutation_p.E257D|BIN2_uc001ryh.2_Missense_Mutation_p.E165D|BIN2_uc010sng.1_Missense_Mutation_p.E263D	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	289						cytoplasm	protein binding			ovary(1)	1						CAGATTCACTCTCACTCTTCA	0.488													0	0	0	0.004289	0	37	83										G	51686023	C	G	51686023	3	3	96	1	0	0	0	0	1	0	0	0	1433	912	32	1	846	1	BIN2	12	51686023	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	218171	51686023	82165872	614	29090										
KRT6B	3854	broad.mit.edu	37	chr12	52843380	52843380	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtccatggatagcaccacgGatgtgtctgagatgtgggtc	14	8	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:52843380G>T	uc001sak.2	-	5	998	c.950C>A	c.(949-951)TCC>TAC	p.S317Y		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	317	Rod.|Linker 12.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TAGCACCACGGATGTGTCTGA	0.527													1	0	2.75727e-19	0.004878	3.49206e-19	20	236										T	52843380	G	T	52843380	3	4	96	1	0	0	0	0	1	0	0	0	8481	1174	41	3	764	3	KRT6B	12	52843380	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1157357	52843380	81008515	615	29091										
HOXC11	3227	broad.mit.edu	37	chr12	54367563	54367563	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaagggcgaggccaaggggGagcccgaggcacccccggcc	18	15	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54367563G>T	uc001sem.2	+	1	654	c.538G>T	c.(538-540)GAG>TAG	p.E180*		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	180					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCCAAGGGGGAGCCCGAGGC	0.721			T	NUP98	AML								1	0	0.000157383	0.00308	0.000187454	8	33										T	54367563	G	T	54367563	4	4	96	1	0	0	0	0	0	1	0	0	7310	1175	41	3	540	3	HOXC11	12	54367563	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1524183	54367563	79484332	616	29092										
HOXC11	3227	broad.mit.edu	37	chr12	54367605	54367605	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgggactggcgtcccgggctGaggcgggtgccgaggcggag	22	11	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54367605G>A	uc001sem.2	+	1	696	c.580G>A	c.(580-582)GAG>AAG	p.E194K		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	194					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTCCCGGGCTGAGGCGGGTGC	0.756			T	NUP98	AML								0	0	0	0.001984	0	7	13										A	54367605	G	A	54367605	3	1	96	1	0	0	0	0	1	0	0	0	7310	1291	45	1	582	1	HOXC11	12	54367605	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	42	54367605	79484290	617	29093										
HNRNPA1	3178	broad.mit.edu	37	chr12	54675946	54675946	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcattaaagaagacactgaaGaacatcacctaagagattat	7	7	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54675946G>C	uc001sfl.2	+	4	456	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.E118Q|HNRNPA1_uc009zng.2_Missense_Mutation_p.E118Q|HNRNPA1_uc009znh.2_Missense_Mutation_p.E118Q|HNRNPA1_uc009zni.2_Missense_Mutation_p.E118Q|HNRNPA1_uc001sfn.2_Missense_Mutation_p.E118Q|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.E73Q|HNRNPA1_uc009znj.1_Missense_Mutation_p.E73Q	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	118	Globular B domain.|RRM 2.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						AGACACTGAAGAACATCACCT	0.383													0	0	0	0.00245	0	14	35										C	54675946	G	C	54675946	3	2	96	1	0	0	0	0	1	0	0	0	7257	943	33	1	366	1	HNRNPA1	12	54675946	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	308341	54675946	79175949	618	29094										
NFE2	4778	broad.mit.edu	37	chr12	54686808	54686808	+	Missense_Mutation	SNP	G	G	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctgtcccctccagctcaaGagattcagcatcgctatagt							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54686808G>A	uc009znk.2	-	2	982	c.472C>T	c.(472-474)CTT>TTT	p.L158F	NFE2_uc001sfq.2_Missense_Mutation_p.L158F|NFE2_uc001sfr.3_Missense_Mutation_p.L158F|NFE2_uc009znl.2_Missense_Mutation_p.L158F	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	158	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						TCCAGCTCAAGAGATTCAGCA	0.572													0	0	0	0.00361	0	48	133										A	54686808	G	A	54686808	3	1	96	1	0	0	0	0	1	0	0	0	10366	942	33	1	653	1	NFE2	12	54686808	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10862	54686808	79165087	619	29095	146	2								
NFE2	4778	broad.mit.edu	37	chr12	54686810	54686810	+	Missense_Mutation	SNP	G	G	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgtcccctccagctcaagaGattcagcatcgctatagttg							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54686810G>A	uc009znk.2	-	2	980	c.470C>T	c.(469-471)TCT>TTT	p.S157F	NFE2_uc001sfq.2_Missense_Mutation_p.S157F|NFE2_uc001sfr.3_Missense_Mutation_p.S157F|NFE2_uc009znl.2_Missense_Mutation_p.S157F	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	157	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						CAGCTCAAGAGATTCAGCATC	0.567													0	0	0	0.00361	0	50	133										A	54686810	G	A	54686810	3	1	96	1	0	0	0	0	1	0	0	0	10366	942	33	1	655	1	NFE2	12	54686810	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2	54686810	79165085	620	29096	146	2								
GPR84	53831	broad.mit.edu	37	chr12	54756605	54756605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccacccggggagcctggactCtggcatccagaatgttgagc	13	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:54756605C>G	uc001sfu.2	-	2	1121	c.1031G>C	c.(1030-1032)AGA>ACA	p.R344T		NM_020370	NP_065103	Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	344	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)	2						AGCCTGGACTCTGGCATCCAG	0.537													0	0	0	0.00361	0	66	150										G	54756605	C	G	54756605	3	3	96	1	0	0	0	0	1	0	0	0	6714	913	32	1	163	1	GPR84	12	54756605	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	69795	54756605	79095290	621	29097										
ERBB3	2065	broad.mit.edu	37	chr12	56481671	56481671	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgagtgtgccgggggctgcTcaggccctcaggacacagac	15	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:56481671T>C	uc001sjh.2	+	6	899	c.706T>C	c.(706-708)TCA>CCA	p.S236P	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.S177P|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	236	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CGGGGGCTGCTCAGGCCCTCA	0.547													0	0	0	0.00361	0	49	140										C	56481671	T	C	56481671	3	2	96	1	0	0	0	0	1	0	0	0	5208	1551	54	5	859	5	ERBB3	12	56481671	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	1725066	56481671	77370224	622	29098										
MYL6	4637	broad.mit.edu	37	chr12	56553863	56553863	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggattatgtcgaaggacttCgggtgtttgacaaggaagga	15	4	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:56553863C>T	uc001sjw.1	+	4	366	c.280C>T	c.(280-282)CGG>TGG	p.R94W	MYL6_uc001sjv.2_Missense_Mutation_p.R94W|MYL6_uc001sjx.1_Missense_Mutation_p.R94W|MYL6_uc010sqd.1_Missense_Mutation_p.R187W|MYL6_uc001sjz.2_Missense_Mutation_p.R59W|MYL6_uc010sqe.1_Missense_Mutation_p.R59W	NM_021019	NP_066299	P60660	MYL6_HUMAN	myosin, light chain 6, alkali, smooth muscle and	94	EF-hand 2.				axon guidance|muscle filament sliding|skeletal muscle tissue development	cytosol|unconventional myosin complex	actin-dependent ATPase activity|calcium ion binding|motor activity|structural constituent of muscle			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			CGAAGGACTTCGGGTGTTTGA	0.512													0	0	0	0.005443	0	27	63										T	56553863	C	T	56553863	3	4	96	1	0	0	0	0	1	0	0	0	10051	875	31	1	294	1	MYL6	12	56553863	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	72192	56553863	77298032	623	29099										
TIMELESS	8914	broad.mit.edu	37	chr12	56822358	56822358	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgatgcggctgctctccctCacagcctcatctggagatat	9	13	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:56822358C>A	uc001slf.2	-	12	1551	c.1383G>T	c.(1381-1383)GTG>GTT	p.V461V	TIMELESS_uc001slg.2_Silent_p.V460V	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	461					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						TGCTCTCCCTCACAGCCTCAT	0.562													1	0	0.00136819	0.001368	0.00162558	12	42										A	56822358	C	A	56822358	2	1	96	1	0	0	0	0	0	0	0	1	15901	813	29	3		3	TIMELESS	12	56822358	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	268495	56822358	77029537	624	29100										
LEMD3	23592	broad.mit.edu	37	chr12	65639552	65639552	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtagacaaaaattcacgtGaggtaaagtaacttttggta	9	5	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:65639552G>A	uc001ssl.1	+	11	2497	c.2491G>A	c.(2491-2493)GAG>AAG	p.E831K	LEMD3_uc009zqo.1_Missense_Mutation_p.E830K	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	831	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		AAATTCACGTGAGGTAAAGTA	0.313													0	0	0	0.002096	0	34	60										A	65639552	G	A	65639552	3	1	96	1	0	0	0	0	1	0	0	0	8721	1291	45	1	2533	1	LEMD3	12	65639552	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8817194	65639552	68212343	625	29101										
MDM1	56890	broad.mit.edu	37	chr12	68707440	68707440	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttaccaacagctggagtagtGagatcatgatgagtcctctg	11	8	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:68707440G>C	uc001stz.2	-	10	1729	c.1593C>G	c.(1591-1593)CTC>CTG	p.L531L	MDM1_uc010stc.1_Silent_p.L496L|MDM1_uc009zqv.1_Silent_p.L251L	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	531						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CTGGAGTAGTGAGATCATGAT	0.408													0	0	0	0.00278	0	24	158										C	68707440	G	C	68707440	2	2	96	1	0	0	0	0	0	0	0	1	9412	1277	45	1		1	MDM1	12	68707440	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3067888	68707440	65144455	626	29102										
TBC1D15	64786	broad.mit.edu	37	chr12	72316827	72316827	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgaagttacaacaccagattCagacgttggtgaagacgaaa	10	7	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:72316827C>T	uc001swu.2	+	18	1994	c.1985C>T	c.(1984-1986)TCA>TTA	p.S662L	TBC1D15_uc010stt.1_Missense_Mutation_p.S631L|TBC1D15_uc001swv.2_Missense_Mutation_p.S645L|TBC1D15_uc001sww.2_Missense_Mutation_p.S394L	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	640							protein binding|Rab GTPase activator activity				0						ACACCAGATTCAGACGTTGGT	0.428													0	0	0	0.006122	0	19	142										T	72316827	C	T	72316827	3	4	96	1	0	0	0	0	1	0	0	0	15601	838	29	1	2113	1	TBC1D15	12	72316827	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3609387	72316827	61535068	627	29103										
LRRIQ1	84125	broad.mit.edu	37	chr12	85466779	85466779	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacttatccctggcacaagtCtggattccaactggattatg	8	10	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:85466779C>T	uc001tac.2	+	11	2901	c.2790C>T	c.(2788-2790)GTC>GTT	p.V930V	LRRIQ1_uc001tab.1_Silent_p.V930V	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	930										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TGGCACAAGTCTGGATTCCAA	0.403													0	0	0	0.00499	0	17	76										T	85466779	C	T	85466779	2	4	96	1	0	0	0	0	0	0	0	1	9029	900	32	1		1	LRRIQ1	12	85466779	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	13149952	85466779	48385116	628	29104										
EEA1	8411	broad.mit.edu	37	chr12	93172980	93172980	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatctgctgatttctcttctCctgttcaacagctgccttca	5	13	5	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:93172980C>G	uc001tck.2	-	25	3830	c.3565G>C	c.(3565-3567)GAG>CAG	p.E1189Q		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	1189	Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TTTCTCTTCTCCTGTTCAACA	0.388													0	0	0	0.002445	0	34	100										G	93172980	C	G	93172980	3	3	96	1	0	0	0	0	1	0	0	0	4921	864	30	1	690	1	EEA1	12	93172980	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7706201	93172980	40678915	629	29105										
DEPDC4	120863	broad.mit.edu	37	chr12	100657378	100657378	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagactaatgttggaatcttCaaattctaattccttttctt	5	7	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:100657378C>G	uc001thi.2	-	2	454	c.451G>C	c.(451-453)GAA>CAA	p.E151Q	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.E84Q|DEPDC4_uc009ztv.1_Missense_Mutation_p.E151Q|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	151	DEP.				intracellular signal transduction						0						TTGGAATCTTCAAATTCTAAT	0.333													0	0	0	0.00499	0	18	39										G	100657378	C	G	100657378	3	3	96	1	0	0	0	0	1	0	0	0	4441	835	29	1	449	1	DEPDC4	12	100657378	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7484398	100657378	33194517	630	29106										
SLC17A8	246213	broad.mit.edu	37	chr12	100797851	100797851	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcagtcccacacatggttatGacaatcgttgtacctattgg	9	10	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:100797851G>A	uc010svi.1	+	9	1402	c.1089G>A	c.(1087-1089)ATG>ATA	p.M363I	SLC17A8_uc009ztx.2_Missense_Mutation_p.M313I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	363	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						ACATGGTTATGACAATCGTTG	0.428													0	0	0	0.001523	0	20	65										A	100797851	G	A	100797851	3	1	96	1	0	0	0	0	1	0	0	0	14423	1290	45	1	1123	1	SLC17A8	12	100797851	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	140473	100797851	33054044	631	29107										
ALDH1L2	160428	broad.mit.edu	37	chr12	105456731	105456731	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagaccaggcttcttggcacCtttaatttccagtggttctc	9	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:105456731C>G	uc001tlc.2	-	7	983	c.856G>C	c.(856-858)GGT>CGT	p.G286R	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	286					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						TTCTTGGCACCTTTAATTTCC	0.403													0	0	0	0.008871	0	19	55										G	105456731	C	G	105456731	3	3	96	1	0	0	0	0	1	0	0	0	495	681	24	4	1983	4	ALDH1L2	12	105456731	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4658880	105456731	28395164	632	29108										
SVOP	55530	broad.mit.edu	37	chr12	109306319	109306319	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccccatcggtcactattcctGagagccagagttcgacctgg	10	14	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:109306319G>C	uc010sxh.1	-	15	1811	c.1639C>G	c.(1639-1641)CAG>GAG	p.Q547E		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	547	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						CACTATTCCTGAGAGCCAGAG	0.632													0	0	0	0.00361	0	67	185										C	109306319	G	C	109306319	3	2	96	1	0	0	0	0	1	0	0	0	15420	1299	45	1	11	1	SVOP	12	109306319	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3849588	109306319	24545576	633	29109										
SVOP	55530	broad.mit.edu	37	chr12	109309593	109309593	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagtgatgagagcacccactCttgccatgccgctgcaggtg	13	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:109309593C>G	uc010sxh.1	-	14	1578	c.1406G>C	c.(1405-1407)AGA>ACA	p.R469T		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	469	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						AGCACCCACTCTTGCCATGCC	0.592													0	0	0	0.001168	0	4	11										G	109309593	C	G	109309593	3	3	96	1	0	0	0	0	1	0	0	0	15420	913	32	1	248	1	SVOP	12	109309593	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3274	109309593	24542302	634	29110										
ERP29	10961	broad.mit.edu	37	chr12	112460294	112460294	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacctgaagatcatggggaaGatcttagaccaaggggagga	14	6	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:112460294G>C	uc001ttk.1	+	3	742	c.624G>C	c.(622-624)AAG>AAC	p.K208N	ERP29_uc001ttl.1_3'UTR	NM_006817	NP_006808	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29 isoform 1	208					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity				0						TCATGGGGAAGATCTTAGACC	0.542													0	0	0	0.00499	0	17	48										C	112460294	G	C	112460294	3	2	96	1	0	0	0	0	1	0	0	0	5242	933	33	1	634	1	ERP29	12	112460294	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3150701	112460294	21391601	635	29111										
TRAFD1	10906	broad.mit.edu	37	chr12	112585913	112585913	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcacgtgccttaccttcactCaatactggcagctcttcccc	5	17	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:112585913C>T	uc001ttp.2	+	8	1049	c.963C>T	c.(961-963)CTC>CTT	p.L321L	TRAFD1_uc001tto.2_Silent_p.L321L|TRAFD1_uc010syj.1_RNA	NM_006700	NP_006691	O14545	TRAD1_HUMAN	TRAF-type zinc finger domain containing 1	321					negative regulation of innate immune response	intracellular	protein binding|zinc ion binding				0						TACCTTCACTCAATACTGGCA	0.423													0	0	0	0.003163	0	15	47										T	112585913	C	T	112585913	2	4	96	1	0	0	0	0	0	0	0	1	16444	813	29	1		1	TRAFD1	12	112585913	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	125619	112585913	21265982	636	29112										
OAS3	4940	broad.mit.edu	37	chr12	113376424	113376424	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggagttcgtagagaaggcgcGgcgcgctctgggcgccctgg	19	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:113376424G>A	uc001tug.2	+	1	176	c.89G>A	c.(88-90)CGG>CAG	p.R30Q	OAS3_uc001tue.2_Missense_Mutation_p.R30Q|OAS3_uc001tuf.2_Missense_Mutation_p.R30Q	NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	30	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GAGAAGGCGCGGCGCGCTCTG	0.721													0	0	0	0.001984	0	6	31										A	113376424	G	A	113376424	3	1	96	1	0	0	0	0	1	0	0	0	10801	1116	39	2	91	2	OAS3	12	113376424	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	790511	113376424	20475471	637	29113										
FBXW8	26259	broad.mit.edu	37	chr12	117402587	117402587	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatcagaggacgaggaggatGagcctggaatgcagccaaat	14	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:117402587G>A	uc001twg.1	+	5	845	c.763G>A	c.(763-765)GAG>AAG	p.E255K	FBXW8_uc001twf.1_Missense_Mutation_p.E189K|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	255	WD 2.						protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		CGAGGAGGATGAGCCTGGAAT	0.522													0	0	0	0.008871	0	19	176										A	117402587	G	A	117402587	3	1	96	1	0	0	0	0	1	0	0	0	5770	1291	45	1	781	1	FBXW8	12	117402587	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4026163	117402587	16449308	638	29114										
CIT	11113	broad.mit.edu	37	chr12	120288075	120288075	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccgctcttcctcaaaaaatGaaacctagggaaaaaagaaa	6	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:120288075G>A	uc001txi.1	-	5	472	c.419C>T	c.(418-420)TCA>TTA	p.S140L	CIT_uc001txj.1_Missense_Mutation_p.S140L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	140	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTCAAAAAATGAAACCTAGGG	0.393													0	0	0	0.00361	0	71	202										A	120288075	G	A	120288075	3	1	96	1	0	0	0	0	1	0	0	0	3438	1294	45	1	5836	1	CIT	12	120288075	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2885488	120288075	13563820	639	29115										
DDX55	57696	broad.mit.edu	37	chr12	124104529	124104529	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agggttctgatattgaagatGaggacatggaagaacttctt	12	4	2	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:124104529G>C	uc001ufi.2	+	14	1669	c.1645G>C	c.(1645-1647)GAG>CAG	p.E549Q	DDX55_uc001ufk.2_Missense_Mutation_p.E402Q|DDX55_uc001ufl.2_Missense_Mutation_p.E156Q	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	549	Lys-rich.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TATTGAAGATGAGGACATGGA	0.348													0	0	0	0.008871	0	19	73										C	124104529	G	C	124104529	3	2	96	1	0	0	0	0	1	0	0	0	4373	1291	45	1	1699	1	DDX55	12	124104529	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3816454	124104529	9747366	640	29116										
ATP6V0A2	23545	broad.mit.edu	37	chr12	124212437	124212437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctatgcagaactggatgaatCccttgaagaccctgaaacag	9	10	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:124212437C>T	uc001ufr.2	+	6	877	c.629C>T	c.(628-630)TCC>TTC	p.S210F	ATP6V0A2_uc001ufq.1_Missense_Mutation_p.S210F	NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	210	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		CTGGATGAATCCCTTGAAGAC	0.408													0	0	0	0.001168	0	6	64										T	124212437	C	T	124212437	3	4	96	1	0	0	0	0	1	0	0	0	1169	855	30	1	651	1	ATP6V0A2	12	124212437	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	107908	124212437	9639458	641	29117										
DNAH10	196385	broad.mit.edu	37	chr12	124398924	124398924	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caccggcgcgtgaagctgctGggggactgcctgctctgcgc	16	14	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:124398924G>A	uc001uft.3	+	60	10072	c.10047G>A	c.(10045-10047)CTG>CTA	p.L3349L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3349					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGAAGCTGCTGGGGGACTGCC	0.607													0	0	0	0.003954	0	23	74										A	124398924	G	A	124398924	2	1	96	1	0	0	0	0	0	0	0	1	4598	1335	47	2		2	DNAH10	12	124398924	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	186487	124398924	9452971	642	29118										
SFRS8	6433	broad.mit.edu	37	chr12	132198734	132198734	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tagaggccctgtgtgatgaaGagaggtatttagccttgcat	13	6	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:132198734G>C	uc001uja.1	+	2	477	c.337G>C	c.(337-339)GAG>CAG	p.E113Q	SFRS8_uc010tbn.1_Missense_Mutation_p.E113Q|SFRS8_uc001ujb.1_5'UTR|SFRS8_uc001uiz.1_Missense_Mutation_p.K2N	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	113					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GTGTGATGAAGAGAGGTATTT	0.453													0	0	0	0.000602	0	5	35										C	132198734	G	C	132198734	3	2	96	1	0	0	0	0	1	0	0	0	14183	943	33	1	343	1	SFRS8	12	132198734	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7799810	132198734	1653161	643	29119										
GOLGA3	2802	broad.mit.edu	37	chr12	133381374	133381374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagcctctggtactgctcctCggccacctgcaagtcgttgt	10	14	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr12:133381374C>T	uc001ukz.1	-	7	2084	c.1525G>A	c.(1525-1527)GAG>AAG	p.E509K	GOLGA3_uc001ula.1_Missense_Mutation_p.E509K|GOLGA3_uc001ulb.2_Missense_Mutation_p.E509K	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	509	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TACTGCTCCTCGGCCACCTGC	0.607													0	0	0	0.00632	0	28	66										T	133381374	C	T	133381374	3	4	96	1	0	0	0	0	1	0	0	0	6554	893	31	1	3181	1	GOLGA3	12	133381374	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1182640	133381374	470521	644	29120										
PARP4	143	broad.mit.edu	37	chr13	25008601	25008601	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgttgtatgcacactatttCatcctcttcttttacttcca	4	11	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:25008601C>T	uc001upl.2	-	31	4784	c.4678G>A	c.(4678-4680)GAA>AAA	p.E1560K		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1560					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		CACACTATTTCATCCTCTTCT	0.398													0	0	0	0.003163	0	16	96										T	25008601	C	T	25008601	3	4	96	1	0	0	0	0	1	0	0	0	11463	835	29	1	512	1	PARP4	13	25008601	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		25008601	90161277	645	29121										
MTMR6	9107	broad.mit.edu	37	chr13	25826037	25826037	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctccaaaactgtaaatctgtGagattcggaactgtagagag	10	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:25826037G>A	uc001uqf.3	-	12	1751	c.1432C>T	c.(1432-1434)CAC>TAC	p.H478Y	MTMR6_uc001uqe.1_Missense_Mutation_p.H478Y	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	478	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GTAAATCTGTGAGATTCGGAA	0.323													0	0	0	0.008361	0	29	204										A	25826037	G	A	25826037	3	1	96	1	0	0	0	0	1	0	0	0	9947	1290	45	1	445	1	MTMR6	13	25826037	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	817436	25826037	89343841	646	29122										
CDK8	1024	broad.mit.edu	37	chr13	26928010	26928010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgctaactgggtgttgcacaGagatttggtaagttgacctg	13	6	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:26928010G>C	uc001uqr.1	+	4	475	c.449G>C	c.(448-450)AGA>ACA	p.R150T	CDK8_uc001uqs.1_Missense_Mutation_p.R150T|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	150	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		GTGTTGCACAGAGATTTGGTA	0.408													0	0	0	0.004482	0	7	44										C	26928010	G	C	26928010	3	2	96	1	0	0	0	0	1	0	0	0	3150	942	33	1	463	1	CDK8	13	26928010	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1101973	26928010	88241868	647	29123										
USPL1	10208	broad.mit.edu	37	chr13	31232711	31232711	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtaagccaccagcaggccctCcatcgtctaatggcacagct	9	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:31232711C>T	uc001utc.2	+	9	2929	c.2497C>T	c.(2497-2499)CCA>TCA	p.P833S	USPL1_uc001utd.2_Missense_Mutation_p.P504S|USPL1_uc001ute.1_Missense_Mutation_p.P504S	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	833					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AGCAGGCCCTCCATCGTCTAA	0.502													0	0	0	0.00499	0	14	97										T	31232711	C	T	31232711	3	4	96	1	0	0	0	0	1	0	0	0	17089	855	30	1	2527	1	USPL1	13	31232711	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4304701	31232711	83937167	648	29124										
FRY	10129	broad.mit.edu	37	chr13	32811517	32811517	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatttatttttatacccagcTcttcctcaccagatttaagc	3	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:32811517T>G	uc001utx.2	+	44	6308	c.5812T>G	c.(5812-5814)TCT>GCT	p.S1938A	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1938					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TATACCCAGCTCTTCCTCACC	0.453													0	0	0	0.008291	0	10	42										G	32811517	T	G	32811517	3	3	96	1	0	0	0	0	1	0	0	0	6063	1565	54	5	5986	5	FRY	13	32811517	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	1578806	32811517	82358361	649	29125										
AKAP11	11215	broad.mit.edu	37	chr13	42874796	42874796	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtatgtaaagaagcagatAttcacaaacacagttgctag	8	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:42874796A>G	uc001uys.1	+	8	2089	c.1914A>G	c.(1912-1914)ATA>ATG	p.I638M		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	638					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		AGAAGCAGATATTCACAAACA	0.398													0	0	0	0.00308	0	8	72										G	42874796	A	G	42874796	3	3	96	1	0	0	0	0	1	0	0	0	447	439	16	5	1936	5	AKAP11	13	42874796	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	10063279	42874796	72295082	650	29126										
PCDH8	5100	broad.mit.edu	37	chr13	53421533	53421533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcgggtgcgttgtcattgaCgtctcggatgcgcacgatga	15	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:53421533C>T	uc001vhi.2	-	1	1242	c.1039G>A	c.(1039-1041)GTC>ATC	p.V347I	PCDH8_uc001vhj.2_Missense_Mutation_p.V347I	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	347	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTGTCATTGACGTCTCGGATG	0.726													0	0	0	0.006214	0	8	31										T	53421533	C	T	53421533	3	4	96	1	0	0	0	0	1	0	0	0	11517	536	19	2	2185	2	PCDH8	13	53421533	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10546737	53421533	61748345	651	29127										
PCDH9	5101	broad.mit.edu	37	chr13	67802023	67802023	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtccaaaaacactctgccCatttaacaattcataatgct	3	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:67802023C>A	uc001vik.2	-	2	1242	c.550G>T	c.(550-552)GGG>TGG	p.G184W	PCDH9_uc001vil.2_Missense_Mutation_p.G184W|PCDH9_uc010thl.1_Missense_Mutation_p.G184W|PCDH9_uc001vin.3_Missense_Mutation_p.G184W	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	184	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACACTCTGCCCATTTAACAAT	0.428													1	0	0.00198382	0.001984	0.00235119	7	141										A	67802023	C	A	67802023	3	1	96	1	0	0	0	0	1	0	0	0	11518	594	21	4	3179	4	PCDH9	13	67802023	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	14380490	67802023	47367855	652	29128										
ITGBL1	9358	broad.mit.edu	37	chr13	102235651	102235651	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catggggacacctgtgaatgTgatgagagggactgtagagc	16	6	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:102235651T>A	uc001vpb.2	+	6	1032	c.813T>A	c.(811-813)TGT>TGA	p.C271*	ITGBL1_uc010agb.2_Nonsense_Mutation_p.C222*|ITGBL1_uc001vpc.3_Nonsense_Mutation_p.C130*	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	271	V.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCTGTGAATGTGATGAGAGGG	0.443													0	0	0	0.002445	0	33	141										A	102235651	T	A	102235651	4	1	96	1	0	0	0	0	0	1	0	0	7902	1702	59	5	835	5	ITGBL1	13	102235651	Nonsense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	34433628	102235651	12934227	653	29129										
MYO16	23026	broad.mit.edu	37	chr13	109613989	109613989	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccgccttcgtttctgacctcCagctcctggaacaaggtcag	9	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:109613989C>T	uc001vqt.1	+	18	2200	c.2074C>T	c.(2074-2076)CAG>TAG	p.Q692*	MYO16_uc010agk.1_Nonsense_Mutation_p.Q714*|MYO16_uc001vqu.1_Nonsense_Mutation_p.Q492*|MYO16_uc010tjh.1_Nonsense_Mutation_p.Q204*	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	692	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCTGACCTCCAGCTCCTGGA	0.458													0	0	0	0.002222	0	40	68										T	109613989	C	T	109613989	4	4	96	1	0	0	0	0	0	1	0	0	10064	595	21	2	2140	2	MYO16	13	109613989	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7378338	109613989	5555889	654	29130										
MCF2L	23263	broad.mit.edu	37	chr13	113720402	113720402	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagaggggcacagtgtcctgGagagcctcagggagctgcag	17	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr13:113720402G>C	uc001vsu.2	+	8	992	c.970G>C	c.(970-972)GAG>CAG	p.E324Q	MCF2L_uc001vsq.2_Missense_Mutation_p.E324Q|MCF2L_uc010tjr.1_Missense_Mutation_p.E267Q|MCF2L_uc001vsr.2_Missense_Mutation_p.E271Q|MCF2L_uc001vss.3_Missense_Mutation_p.E265Q|MCF2L_uc010tjs.1_Missense_Mutation_p.E265Q|MCF2L_uc001vst.1_Missense_Mutation_p.E229Q	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	297					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				CAGTGTCCTGGAGAGCCTCAG	0.642													0	0	0	0.006214	0	9	19										C	113720402	G	C	113720402	3	2	96	1	0	0	0	0	1	0	0	0	9379	1175	41	1	1095	1	MCF2L	13	113720402	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4106413	113720402	1449476	655	29131										
PABPN1	8106	broad.mit.edu	37	chr14	23792231	23792231	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcccggtgatcatgtccattGaggagaagatggaggctgat	15	7	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:23792231G>A	uc001wjk.2	+	3	1772	c.490G>A	c.(490-492)GAG>AAG	p.E164K	PABPN1_uc001wjh.3_Missense_Mutation_p.E191K|PABPN1_uc001wjj.2_Missense_Mutation_p.E164K	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	164	Necessary for homooligomerization.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CATGTCCATTGAGGAGAAGAT	0.418													0	0	0	0.00361	0	62	132										A	23792231	G	A	23792231	3	1	96	1	0	0	0	0	1	0	0	0	11368	1291	45	1	500	1	PABPN1	14	23792231	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		23792231	83557309	656	29132										
REC8	9985	broad.mit.edu	37	chr14	24648862	24648862	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccgtggtgcctgaactccctGaggtgcccatggagatgcct	13	13	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:24648862G>C	uc001wmr.2	+	19	1808	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	REC8_uc001wms.2_Missense_Mutation_p.E461Q	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	461	Glu-rich.				mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		TGAACTCCCTGAGGTGCCCAT	0.627													0	0	0	0.003954	0	27	68										C	24648862	G	C	24648862	3	2	96	1	0	0	0	0	1	0	0	0	13199	1291	45	1	1444	1	REC8	14	24648862	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	856631	24648862	82700678	657	29133										
KHNYN	23351	broad.mit.edu	37	chr14	24901328	24901328	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgggagagagaagtggccctCaggccacagtcagtgggtgg	18	8	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:24901328C>G	uc001wph.3	+	3	1063	c.861C>G	c.(859-861)CTC>CTG	p.L287L	KHNYN_uc010tpc.1_Silent_p.L328L|KHNYN_uc010alw.2_Silent_p.L287L|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	287										ovary(2)|liver(1)	3						AAGTGGCCCTCAGGCCACAGT	0.627											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	8	46										G	24901328	C	G	24901328	2	3	96	1	0	0	0	0	0	0	0	1	8150	813	29	1		1	KHNYN	14	24901328	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	252466	24901328	82448212	658	29134										
RALGAPA1	253959	broad.mit.edu	37	chr14	36096603	36096603	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagctcatcaagaacatcttCttcatctcttattgtatccc	4	12	6	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:36096603C>G	uc001wti.2	-	33	5423	c.5032G>C	c.(5032-5034)GAA>CAA	p.E1678Q	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.E1678Q|RALGAPA1_uc010tpv.1_Missense_Mutation_p.E1691Q|RALGAPA1_uc010tpw.1_Missense_Mutation_p.E1725Q	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1678	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AGAACATCTTCTTCATCTCTT	0.368													0	0	0	0.000978	0	11	121										G	36096603	C	G	36096603	3	3	96	1	0	0	0	0	1	0	0	0	13013	922	32	1	1263	1	RALGAPA1	14	36096603	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	11195275	36096603	71252937	659	29135										
MGAT2	4247	broad.mit.edu	37	chr14	50088560	50088560	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctaacgagtttccaggtagtGaccctagagattgtcccaga	10	10	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:50088560G>A	uc001wwr.2	+	1	1072	c.574G>A	c.(574-576)GAC>AAC	p.D192N	SDCCAG1_uc010anj.1_Intron|RPL36AL_uc001wwq.1_5'Flank	NM_002408	NP_002399	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein	192	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TCCAGGTAGTGACCCTAGAGA	0.507													0	0	0	0.002222	0	45	121										A	50088560	G	A	50088560	3	1	96	1	0	0	0	0	1	0	0	0	9543	1290	45	1	576	1	MGAT2	14	50088560	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	13991957	50088560	57260980	660	29136										
KLHDC1	122773	broad.mit.edu	37	chr14	50175883	50175883	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttctgtatttttagtctattGaagacaatgaagtatatttg	7	3	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:50175883G>T	uc001www.2	+	2	131	c.103G>T	c.(103-105)GAA>TAA	p.E35*	SDCCAG1_uc010anj.1_Intron|KLHDC1_uc010tqg.1_5'UTR|KLHDC1_uc010tqh.1_5'UTR	NM_172193	NP_751943	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	35	Kelch 1.					cytoplasm				pancreas(1)	1	all_epithelial(31;0.00244)|Breast(41;0.00964)					TTAGTCTATTGAAGACAATGA	0.289													1	0	9.31168e-06	0.001855	1.12208e-05	13	74										T	50175883	G	T	50175883	4	4	96	1	0	0	0	0	0	1	0	0	8354	1291	45	3	109	3	KLHDC1	14	50175883	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	87323	50175883	57173657	661	29137										
GNPNAT1	64841	broad.mit.edu	37	chr14	53248520	53248520	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accttagcacaggaatggatGaatttatgttctataatcag	8	6	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:53248520G>A	uc001xab.2	-	4	582	c.327C>T	c.(325-327)TTC>TTT	p.F109F		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	109	Substrate binding.|N-acetyltransferase.				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					AGGAATGGATGAATTTATGTT	0.358													0	0	0	0.007291	0	30	106										A	53248520	G	A	53248520	2	1	96	1	0	0	0	0	0	0	0	1	6544	1281	45	1		1	GNPNAT1	14	53248520	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3072637	53248520	54101020	662	29138										
FBXO34	55030	broad.mit.edu	37	chr14	55817300	55817300	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcgaaagccatttgggatCctttctccaaatgttctgtg	8	10	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:55817300C>G	uc001xbu.2	+	2	437	c.192C>G	c.(190-192)ATC>ATG	p.I64M	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Missense_Mutation_p.I64M	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	64										ovary(2)|lung(2)|skin(1)	5						CATTTGGGATCCTTTCTCCAA	0.438													0	0	0	0.00361	0	54	109										G	55817300	C	G	55817300	3	3	96	1	0	0	0	0	1	0	0	0	5744	845	30	1	194	1	FBXO34	14	55817300	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2568780	55817300	51532240	663	29139										
FBXO34	55030	broad.mit.edu	37	chr14	55817474	55817474	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accaaggaaaaaattgcattCtttgcatcccaccagtgtag	7	10	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:55817474C>G	uc001xbu.2	+	2	611	c.366C>G	c.(364-366)TTC>TTG	p.F122L	FBXO34_uc001xbv.2_5'Flank|FBXO34_uc010aoo.2_Missense_Mutation_p.F122L	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	122										ovary(2)|lung(2)|skin(1)	5						AAATTGCATTCTTTGCATCCC	0.428													0	0	0	0.002299	0	23	34										G	55817474	C	G	55817474	3	3	96	1	0	0	0	0	1	0	0	0	5744	912	32	1	368	1	FBXO34	14	55817474	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	174	55817474	51532066	664	29140										
DAAM1	23002	broad.mit.edu	37	chr14	59819345	59819345	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gataggttcctttttgagatGagccggtgagtttgaaaatg	13	4	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:59819345G>A	uc001xdz.1	+	19	2417	c.2292G>A	c.(2290-2292)ATG>ATA	p.M764I	DAAM1_uc001xea.1_Missense_Mutation_p.M754I|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	764	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TTTTTGAGATGAGCCGGTGAG	0.398													0	0	0	0.000248	0	4	14										A	59819345	G	A	59819345	3	1	96	1	0	0	0	0	1	0	0	0	4215	1290	45	1	2362	1	DAAM1	14	59819345	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4001871	59819345	47530195	665	29141										
DAAM1	23002	broad.mit.edu	37	chr14	59834201	59834201	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctggcaaaatacaaccagatGagttctttggcatttttgat	8	7	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:59834201G>C	uc001xdz.1	+	25	3036	c.2911G>C	c.(2911-2913)GAG>CAG	p.E971Q	DAAM1_uc001xea.1_Missense_Mutation_p.E961Q|DAAM1_uc001xec.1_RNA	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	971	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ACAACCAGATGAGTTCTTTGG	0.378													0	0	0	0.003163	0	14	62										C	59834201	G	C	59834201	3	2	96	1	0	0	0	0	1	0	0	0	4215	1291	45	1	3005	1	DAAM1	14	59834201	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	14856	59834201	47515339	666	29142										
SIX1	6495	broad.mit.edu	37	chr14	61115580	61115580	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggaaattttcggcgcacccGatatttgcccacggcgccca	10	14	0	0	rs80356459		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:61115580G>A	uc001xfb.3	-	1	576	c.328C>T	c.(328-330)CGG>TGG	p.R110W		NM_005982	NP_005973	Q15475	SIX1_HUMAN	SIX homeobox 1	110			R -> Q (in BOS3).|R -> W (in BOS3; crucial for EYA1-SIX1 interaction).		branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CGGCGCACCCGATATTTGCCC	0.632													0	0	0	0.007835	0	43	76										A	61115580	G	A	61115580	3	1	96	1	0	0	0	0	1	0	0	0	14346	1057	37	1	534	1	SIX1	14	61115580	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1281379	61115580	46233960	667	29143										
GPHN	10243	broad.mit.edu	37	chr14	67291216	67291216	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccctgatagattggtgtgatGaaaaggaacttaatttgata	10	4	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:67291216G>A	uc001xiy.2	+	4	1347	c.226G>A	c.(226-228)GAA>AAA	p.E76K	GPHN_uc001xiw.2_Intron|GPHN_uc001xix.2_Missense_Mutation_p.E76K|GPHN_uc010tss.1_Missense_Mutation_p.E76K|GPHN_uc010tst.1_Intron|GPHN_uc010tsu.1_5'UTR	NM_001024218	NP_001019389	Q9NQX3	GEPH_HUMAN	gephyrin isoform 2	76	MPT Mo-transferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			ovary(2)	2		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		TTGGTGTGATGAAAAGGAACT	0.398			T	MLL	AL								0	0	0	0.001368	0	11	35										A	67291216	G	A	67291216	3	1	96	1	0	0	0	0	1	0	0	0	6610	1291	45	1	240	1	GPHN	14	67291216	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6175636	67291216	40058324	668	29144										
PCNX	22990	broad.mit.edu	37	chr14	71479708	71479708	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgactttcttttagctctctCtcccacagattcgattgaat	5	11	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:71479708C>G	uc001xmo.2	+	11	3231	c.2785C>G	c.(2785-2787)CTC>GTC	p.L929V	PCNX_uc010are.1_Intron|PCNX_uc010arf.1_5'Flank	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	929						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTAGCTCTCTCTCCCACAGAT	0.328													0	0	0	0.006214	0	9	62										G	71479708	C	G	71479708	3	3	96	1	0	0	0	0	1	0	0	0	11591	913	32	1	2827	1	PCNX	14	71479708	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4188492	71479708	35869832	669	29145										
DCAF4	26094	broad.mit.edu	37	chr14	73404761	73404761	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagaacccttggttcagactCcgtgattctgaagacaggca	10	11	2	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:73404761C>G	uc001xng.2	+	2	295	c.75C>G	c.(73-75)CTC>CTG	p.L25L	DCAF4_uc001xnj.2_Silent_p.L25L|DCAF4_uc010ttr.1_Missense_Mutation_p.S14C|DCAF4_uc001xnh.2_Intron|DCAF4_uc010tts.1_Silent_p.L25L|DCAF4_uc010ttt.1_5'UTR|DCAF4_uc001xni.2_Silent_p.L25L|DCAF4_uc001xnk.2_Silent_p.L25L	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1	25						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GGTTCAGACTCCGTGATTCTG	0.488													0	0	0	0.004878	0	35	102										G	73404761	C	G	73404761	2	3	96	1	0	0	0	0	0	0	0	1	4270	855	30	1		1	DCAF4	14	73404761	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1925053	73404761	33944779	670	29146										
RBM25	58517	broad.mit.edu	37	chr14	73576063	73576063	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttacagaggaagtgctcttCagaaaaggttgcgtgataga	12	5	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:73576063C>T	uc001xno.2	+	14	1763	c.1555C>T	c.(1555-1557)CAG>TAG	p.Q519*	RBM25_uc010ttu.1_Nonsense_Mutation_p.Q519*|RBM25_uc001xnp.2_Nonsense_Mutation_p.Q314*	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	519	Necessary for nuclear speckle localization.|Glu-rich.|Arg-rich.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		AAGTGCTCTTCAGAAAAGGTT	0.428													0	0	0	0.00874	0	37	118										T	73576063	C	T	73576063	4	4	96	1	0	0	0	0	0	1	0	0	13125	827	29	1	1605	1	RBM25	14	73576063	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	171302	73576063	33773477	671	29147										
FAM161B	145483	broad.mit.edu	37	chr14	74411204	74411204	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgaagggcttcaaagaagaGaggagcagttccttcctctt	11	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:74411204G>C	uc001xpd.1	-	3	865	c.759C>G	c.(757-759)CTC>CTG	p.L253L		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						TCAAAGAAGAGAGGAGCAGTT	0.567													0	0	0	0.004656	0	26	74										C	74411204	G	C	74411204	2	2	96	1	0	0	0	0	0	0	0	1	5473	929	33	1		1	FAM161B	14	74411204	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	835141	74411204	32938336	672	29148										
TMED8	283578	broad.mit.edu	37	chr14	77808143	77808143	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtagtagatgtggaagtagaGagtcttgttgcgcagcaggg	17	4	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:77808143G>C	uc001xto.1	-	6	949	c.949C>G	c.(949-951)CTC>GTC	p.L317V	TMED8_uc010ast.1_RNA|TMED8_uc001xtn.1_Missense_Mutation_p.L161V	NM_213601	NP_998766	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain	317	GOLD.				transport	integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		TGGAAGTAGAGAGTCTTGTTG	0.577													0	0	0	0.002522	0	38	86										C	77808143	G	C	77808143	3	2	96	1	0	0	0	0	1	0	0	0	16008	942	33	1	31	1	TMED8	14	77808143	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3396939	77808143	29541397	673	29149										
AHSA1	10598	broad.mit.edu	37	chr14	77934848	77934848	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaggtttaaatcttggccaGagggtaagtaaacatattta	11	4	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:77934848G>A	uc001xtw.2	+	8	1001	c.841G>A	c.(841-843)GAG>AAG	p.E281K	AHSA1_uc010tvk.1_Missense_Mutation_p.E281K	NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	281					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		ATCTTGGCCAGAGGGTAAGTA	0.279													0	0	0	0.008871	0	18	61										A	77934848	G	A	77934848	3	1	96	1	0	0	0	0	1	0	0	0	418	943	33	1	871	1	AHSA1	14	77934848	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	126705	77934848	29414692	674	29150										
EML5	161436	broad.mit.edu	37	chr14	89124543	89124543	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgacgtacccccatcttcttCagaatcaatgtcggattctt	6	12	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:89124543C>T	uc001xxg.2	-	27	4051	c.3865G>A	c.(3865-3867)GAA>AAA	p.E1289K	EML5_uc001xxf.2_Missense_Mutation_p.E84K|EML5_uc001xxh.1_Missense_Mutation_p.E428K	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1289						cytoplasm|microtubule				ovary(3)	3						CCATCTTCTTCAGAATCAATG	0.363													0	0	0	0.005443	0	27	77										T	89124543	C	T	89124543	3	4	96	1	0	0	0	0	1	0	0	0	5100	835	29	1	2140	1	EML5	14	89124543	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	11189695	89124543	18224997	675	29151										
DDX24	57062	broad.mit.edu	37	chr14	94528596	94528596	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttttagatttccagtctgctCtttatcaagattttcctcct	4	10	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:94528596C>G	uc001ycj.2	-	3	1189	c.1090G>C	c.(1090-1092)GAG>CAG	p.E364Q	DDX24_uc010twq.1_Missense_Mutation_p.E321Q|DDX24_uc010twr.1_Missense_Mutation_p.E114Q	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	364	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CCAGTCTGCTCTTTATCAAGA	0.483													0	0	0	0.002852	0	41	110										G	94528596	C	G	94528596	3	3	96	1	0	0	0	0	1	0	0	0	4351	922	32	1	1517	1	DDX24	14	94528596	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5404053	94528596	12820944	676	29152										
DYNC1H1	1778	broad.mit.edu	37	chr14	102493971	102493971	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccaggtgcctggtctctttGaaggagacgagtatgccacc	12	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:102493971G>C	uc001yks.2	+	47	9228	c.9064G>C	c.(9064-9066)GAA>CAA	p.E3022Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3022	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGGTCTCTTTGAAGGAGACGA	0.542													0	0	0	0.004007	0	17	44										C	102493971	G	C	102493971	3	2	96	1	0	0	0	0	1	0	0	0	4841	1291	45	1	9250	1	DYNC1H1	14	102493971	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7965375	102493971	4855569	677	29153										
DYNC1H1	1778	broad.mit.edu	37	chr14	102502930	102502930	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttcctggatgacgccttcaGaaagaacttagagagtgcac	10	10	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr14:102502930G>A	uc001yks.2	+	57	11023	c.10859G>A	c.(10858-10860)AGA>AAA	p.R3620K		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3620	AAA 5 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GACGCCTTCAGAAAGAACTTA	0.468													0	0	0	0.007835	0	40	118										A	102502930	G	A	102502930	3	1	96	1	0	0	0	0	1	0	0	0	4841	942	33	1	11085	1	DYNC1H1	14	102502930	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8959	102502930	4846610	678	29154										
OR4M2	390538	broad.mit.edu	37	chr15	22369079	22369079	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcattgttcgacttcctttCtgtgggcccaatgagttaga	9	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:22369079C>T	uc010tzu.1	+	1	504	c.504C>T	c.(502-504)TTC>TTT	p.F168F	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GACTTCCTTTCTGTGGGCCCA	0.493													0	0	0	0.00361	0	68	406										T	22369079	C	T	22369079	2	4	96	1	0	0	0	0	0	0	0	1	11076	912	32	1		1	OR4M2	15	22369079	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		22369079	80162313	679	29155										
MKRN3	7681	broad.mit.edu	37	chr15	23811021	23811021	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggagggtgtgtctgggccggAccttcccgtctgtgagccct	16	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:23811021A>G	uc001ywh.3	+	1	568	c.92A>G	c.(91-93)GAC>GGC	p.D31G	MKRN3_uc001ywi.2_Missense_Mutation_p.D31G|MKRN3_uc010ayi.1_Missense_Mutation_p.D31G	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	31						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TCTGGGCCGGACCTTCCCGTC	0.667													0	0	0	0.004672	0	3	40										G	23811021	A	G	23811021	3	3	96	1	0	0	0	0	1	0	0	0	9608	275	10	5	94	5	MKRN3	15	23811021	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	1441942	23811021	78720371	680	29156										
OCA2	4948	broad.mit.edu	37	chr15	28277301	28277301	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggacatctggggcaaagaaGagtgagacctgaaagagaca	14	6	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:28277301G>T	uc001zbh.3	-	3	346	c.236C>A	c.(235-237)TCT>TAT	p.S79Y	OCA2_uc010ayv.2_Missense_Mutation_p.S79Y	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	79	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		GGGCAAAGAAGAGTGAGACCT	0.443									Oculocutaneous_Albinism				1	0	1.75199e-13	0.007291	2.18998e-13	31	82										T	28277301	G	T	28277301	3	4	96	1	0	0	0	0	1	0	0	0	10815	942	33	3	2368	3	OCA2	15	28277301	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4466280	28277301	74254091	681	29157										
HERC2	8924	broad.mit.edu	37	chr15	28437183	28437183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgcctggttcacggaggacGacacattcaggctcttcacc	10	13	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:28437183G>A	uc001zbj.2	-	53	8481	c.8375C>T	c.(8374-8376)TCG>TTG	p.S2792L	HERC2_uc001zbk.1_Missense_Mutation_p.S327L	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2792	DOC.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CACGGAGGACGACACATTCAG	0.587											OREG0022997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	53	166										A	28437183	G	A	28437183	3	1	96	1	0	0	0	0	1	0	0	0	7058	1059	37	1	6293	1	HERC2	15	28437183	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	159882	28437183	74094209	682	29158										
ARHGAP11A	9824	broad.mit.edu	37	chr15	32929006	32929006	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagggacttttcaccccttCaaactcaaacatttaataga	5	10	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:32929006C>T	uc001zgy.1	+	12	2754	c.2032C>T	c.(2032-2034)CAA>TAA	p.Q678*	ARHGAP11A_uc010ubw.1_Nonsense_Mutation_p.Q489*|ARHGAP11A_uc010ubx.1_Nonsense_Mutation_p.Q489*	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	678					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TTCACCCCTTCAAACTCAAAC	0.308													0	0	0	0.001984	0	7	29										T	32929006	C	T	32929006	4	4	96	1	0	0	0	0	0	1	0	0	863	827	29	1	2101	1	ARHGAP11A	15	32929006	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4491823	32929006	69602386	683	29159										
SCG5	6447	broad.mit.edu	37	chr15	32988730	32988730	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcagagtgtcaatccatatCtacaaggacagagactggat	9	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:32988730C>G	uc001zha.2	+	6	676	c.559C>G	c.(559-561)CTA>GTA	p.L187V	SCG5_uc001zgz.2_Missense_Mutation_p.L186V	NM_001144757	NP_001138229	P05408	7B2_HUMAN	secretogranin V isoform 1	187					intracellular protein transport|neuropeptide signaling pathway|peptide hormone processing|regulation of hormone secretion	extracellular region|stored secretory granule	enzyme inhibitor activity|GTP binding|unfolded protein binding				0		all_lung(180;7.32e-08)		all cancers(64;6.48e-17)|Epithelial(43;1.23e-11)|GBM - Glioblastoma multiforme(186;1.39e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0212)		CAATCCATATCTACAAGGACA	0.373													0	0	0	0.00245	0	13	26										G	32988730	C	G	32988730	3	3	96	1	0	0	0	0	1	0	0	0	13893	912	32	1	577	1	SCG5	15	32988730	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	59724	32988730	69542662	684	29160										
FAM98B	283742	broad.mit.edu	37	chr15	38766480	38766480	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtgactgtacagtcctttgGatggtctgatagagcaaagg	13	6	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:38766480G>C	uc001zkb.1	+	6	745	c.710G>C	c.(709-711)GGA>GCA	p.G237A	FAM98B_uc001zkc.2_Missense_Mutation_p.G237A	NM_001042429	NP_001035894	Q52LJ0	FA98B_HUMAN	family with sequence similarity 98, member B	237						tRNA-splicing ligase complex	protein binding			ovary(1)	1		all_cancers(109;3.11e-17)|all_epithelial(112;2.64e-15)|Lung NSC(122;2.11e-11)|all_lung(180;5.61e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;9e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0209)		CAGTCCTTTGGATGGTCTGAT	0.428													0	0	0	0.007413	0	18	188										C	38766480	G	C	38766480	3	2	96	1	0	0	0	0	1	0	0	0	5657	1174	41	1	732	1	FAM98B	15	38766480	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5777750	38766480	63764912	685	29161										
C15orf23	90417	broad.mit.edu	37	chr15	40675092	40675092	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttccgtacaacatggctgtCtacagagtgcgattcccacc	8	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:40675092C>T	uc001zll.2	+	1	171	c.56C>T	c.(55-57)TCT>TTT	p.S19F	C15orf23_uc010ucp.1_Missense_Mutation_p.S19F|C15orf23_uc001zlo.2_Missense_Mutation_p.S19F|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	19						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		ACATGGCTGTCTACAGAGTGC	0.592													0	0	0	0.001168	0	6	44										T	40675092	C	T	40675092	3	4	96	1	0	0	0	0	1	0	0	0	1785	913	32	1	58	1	C15orf23	15	40675092	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1908612	40675092	61856300	686	29162										
NUSAP1	51203	broad.mit.edu	37	chr15	41648287	41648287	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaaagaaatctctctacacaGatgagtcatccaaacctgga	7	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:41648287G>T	uc001zns.3	+	5	729	c.499G>T	c.(499-501)GAT>TAT	p.D167Y	NUSAP1_uc001znq.3_5'UTR|NUSAP1_uc001znr.3_Missense_Mutation_p.D167Y|NUSAP1_uc010bce.2_Missense_Mutation_p.D167Y|NUSAP1_uc001znt.3_Missense_Mutation_p.D152Y|NUSAP1_uc001znv.3_Missense_Mutation_p.D166Y|NUSAP1_uc001znu.3_Missense_Mutation_p.D166Y|NUSAP1_uc010ucw.1_Missense_Mutation_p.D144Y|NUSAP1_uc001znw.3_5'UTR	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	167					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		TCTCTACACAGATGAGTCATC	0.358													1	0	0.00198382	0.001984	0.00235119	5	20										T	41648287	G	T	41648287	3	4	96	1	0	0	0	0	1	0	0	0	10778	942	33	3	517	3	NUSAP1	15	41648287	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	973195	41648287	60883105	687	29163										
MGA	23269	broad.mit.edu	37	chr15	42021428	42021428	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgatgacttgtgctcgagttCgagtatatgagcgaaaaaaa	11	5	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42021428C>T	uc010ucy.1	+	11	3905	c.3724C>T	c.(3724-3726)CGA>TGA	p.R1242*	MGA_uc010ucz.1_Nonsense_Mutation_p.R1242*	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1242						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.R1242P(1)		ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGCTCGAGTTCGAGTATATGA	0.413													0	0	0	0.001368	0	12	46										T	42021428	C	T	42021428	4	4	96	1	0	0	0	0	0	1	0	0	9540	876	31	1	3762	1	MGA	15	42021428	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	373141	42021428	60509964	688	29164										
MGA	23269	broad.mit.edu	37	chr15	42028655	42028655	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcttctcgtgtgaaaatctCtatgccatcatgtcaagacc	6	11	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42028655C>G	uc010ucy.1	+	13	4374	c.4193C>G	c.(4192-4194)TCT>TGT	p.S1398C	MGA_uc010ucz.1_Missense_Mutation_p.S1398C|MGA_uc010uda.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1398						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GTGAAAATCTCTATGCCATCA	0.468													0	0	0	0.00499	0	17	56										G	42028655	C	G	42028655	3	3	96	1	0	0	0	0	1	0	0	0	9540	913	32	1	4239	1	MGA	15	42028655	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7227	42028655	60502737	689	29165										
MGA	23269	broad.mit.edu	37	chr15	42028795	42028795	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attcagtgagggagagattaCatggaggcaaaggtctgcct	14	6	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42028795C>T	uc010ucy.1	+	13	4514	c.4333C>T	c.(4333-4335)CAT>TAT	p.H1445Y	MGA_uc010ucz.1_Missense_Mutation_p.H1445Y|MGA_uc010uda.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1445						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGAGAGATTACATGGAGGCAA	0.493													0	0	0	0.001855	0	13	47										T	42028795	C	T	42028795	3	4	96	1	0	0	0	0	1	0	0	0	9540	478	17	2	4379	2	MGA	15	42028795	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	140	42028795	60502597	690	29166										
MGA	23269	broad.mit.edu	37	chr15	42042799	42042799	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actaccagagtgaggaggttGatgatgtagaaaaggtggtg	16	3	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42042799G>C	uc010ucy.1	+	17	7175	c.6994G>C	c.(6994-6996)GAT>CAT	p.D2332H	MGA_uc010ucz.1_Missense_Mutation_p.D2123H|MGA_uc010uda.1_Missense_Mutation_p.D948H|MGA_uc001zoi.2_Missense_Mutation_p.D546H	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2293	Basic motif.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGAGGAGGTTGATGATGTAGA	0.348													0	0	0	0.001168	0	5	19										C	42042799	G	C	42042799	3	2	96	1	0	0	0	0	1	0	0	0	9540	1290	45	1	7056	1	MGA	15	42042799	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	14004	42042799	60488593	691	29167										
MAPKBP1	23005	broad.mit.edu	37	chr15	42092064	42092064	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aattacagtgtctggaggcaGaggacttgcctgtgaccccc	12	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42092064G>T	uc001zok.3	+	3	444	c.158G>T	c.(157-159)AGA>ATA	p.R53I	MAPKBP1_uc001zoj.3_Missense_Mutation_p.R53I|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.R53I|MAPKBP1_uc010udb.1_Intron|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	53										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCTGGAGGCAGAGGACTTGCC	0.498													1	0	4.79706e-38	0.00361	6.14024e-38	61	169										T	42092064	G	T	42092064	3	4	96	1	0	0	0	0	1	0	0	0	9292	942	33	3	164	3	MAPKBP1	15	42092064	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	49265	42092064	60439328	692	29168										
MAPKBP1	23005	broad.mit.edu	37	chr15	42092078	42092078	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaggcagaggacttgcctgtGacccccgatcaggtttagtt	13	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42092078G>A	uc001zok.3	+	3	458	c.172G>A	c.(172-174)GAC>AAC	p.D58N	MAPKBP1_uc001zoj.3_Missense_Mutation_p.D58N|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Missense_Mutation_p.D58N|MAPKBP1_uc010udb.1_Intron|MAPKBP1_uc010bck.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	58										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ACTTGCCTGTGACCCCCGATC	0.502													0	0	0	0.00361	0	57	162										A	42092078	G	A	42092078	3	1	96	1	0	0	0	0	1	0	0	0	9292	1290	45	1	178	1	MAPKBP1	15	42092078	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	14	42092078	60439314	693	29169										
GANC	2595	broad.mit.edu	37	chr15	42584941	42584941	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgttttctaggctgatttCatgctctggggacacaggca	11	8	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:42584941C>T	uc001zpi.2	+	5	652	c.338C>T	c.(337-339)TCA>TTA	p.S113L	GANC_uc001zph.2_Missense_Mutation_p.S113L|GANC_uc001zpj.1_5'UTR	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	113					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AGGCTGATTTCATGCTCTGGG	0.413													0	0	0	0.005443	0	29	70										T	42584941	C	T	42584941	3	4	96	1	0	0	0	0	1	0	0	0	6234	838	29	1	356	1	GANC	15	42584941	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	492863	42584941	59946451	694	29170										
UBR1	197131	broad.mit.edu	37	chr15	43281096	43281096	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctttcatcaggtggcactttCaatccaattctataaattgt	5	9	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:43281096C>G	uc001zqq.2	-	35	3984	c.3918G>C	c.(3916-3918)TTG>TTC	p.L1306F		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1306					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GTGGCACTTTCAATCCAATTC	0.373													0	0	0	0.003755	0	38	105										G	43281096	C	G	43281096	3	3	96	1	0	0	0	0	1	0	0	0	16898	825	29	1	1383	1	UBR1	15	43281096	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	696155	43281096	59250296	695	29171										
SQRDL	58472	broad.mit.edu	37	chr15	45965961	45965961	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgaagtgtgctggagcccctCagaagatcatgtacttatca	10	9	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:45965961C>T	uc001zvt.2	+	6	805	c.616C>T	c.(616-618)CAG>TAG	p.Q206*	SQRDL_uc001zvu.2_Nonsense_Mutation_p.Q206*|SQRDL_uc001zvv.2_Nonsense_Mutation_p.Q206*	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	206							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TGGAGCCCCTCAGAAGATCAT	0.478													0	0	0	0.003163	0	15	64										T	45965961	C	T	45965961	4	4	96	1	0	0	0	0	0	1	0	0	15128	827	29	1	630	1	SQRDL	15	45965961	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2684865	45965961	56565431	696	29172										
DMXL2	23312	broad.mit.edu	37	chr15	51772908	51772908	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcgtttggcctgcaatcttCttctttctatttgatggcgc	8	11	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51772908C>G	uc002abf.2	-	24	6620	c.6395G>C	c.(6394-6396)AGA>ACA	p.R2132T	DMXL2_uc002abd.2_Missense_Mutation_p.R202T|DMXL2_uc010ufy.1_Missense_Mutation_p.R2132T|DMXL2_uc010bfa.2_Missense_Mutation_p.R1496T	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2132	Potential.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CTGCAATCTTCTTCTTTCTAT	0.423													0	0	0	0.002836	0	33	136										G	51772908	C	G	51772908	3	3	96	1	0	0	0	0	1	0	0	0	4595	913	32	1	2798	1	DMXL2	15	51772908	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5806947	51772908	50758484	697	29173										
DMXL2	23312	broad.mit.edu	37	chr15	51772963	51772963	+	Missense_Mutation	SNP	C	C	T													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atctggtttgtctaccatttCttcctgatccagcagatcac							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51772963C>T	uc002abf.2	-	24	6565	c.6340G>A	c.(6340-6342)GAA>AAA	p.E2114K	DMXL2_uc002abd.2_Missense_Mutation_p.E184K|DMXL2_uc010ufy.1_Missense_Mutation_p.E2114K|DMXL2_uc010bfa.2_Missense_Mutation_p.E1478K	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2114						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCTACCATTTCTTCCTGATCC	0.398													0	0	0	0.004656	0	25	130										T	51772963	C	T	51772963	3	4	96	1	0	0	0	0	1	0	0	0	4595	922	32	1	2853	1	DMXL2	15	51772963	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	55	51772963	50758429	698	29174	147	2								
DMXL2	23312	broad.mit.edu	37	chr15	51772972	51772972	+	Missense_Mutation	SNP	C	C	G													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtctaccatttcttcctgatCcagcagatcactctctactt							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51772972C>G	uc002abf.2	-	24	6556	c.6331G>C	c.(6331-6333)GAT>CAT	p.D2111H	DMXL2_uc002abd.2_Missense_Mutation_p.D181H|DMXL2_uc010ufy.1_Missense_Mutation_p.D2111H|DMXL2_uc010bfa.2_Missense_Mutation_p.D1475H	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2111						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCTTCCTGATCCAGCAGATCA	0.393													0	0	0	0.00333	0	22	125										G	51772972	C	G	51772972	3	3	96	1	0	0	0	0	1	0	0	0	4595	855	30	1	2862	1	DMXL2	15	51772972	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9	51772972	50758420	699	29175	147	2								
DMXL2	23312	broad.mit.edu	37	chr15	51773374	51773374	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcgtgatcttcaccccaatCaagattaagaggttcctcat	7	11	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:51773374C>G	uc002abf.2	-	24	6154	c.5929G>C	c.(5929-5931)GAT>CAT	p.D1977H	DMXL2_uc002abd.2_Missense_Mutation_p.D47H|DMXL2_uc010ufy.1_Missense_Mutation_p.D1977H|DMXL2_uc010bfa.2_Missense_Mutation_p.D1341H	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1977						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCACCCCAATCAAGATTAAGA	0.408													0	0	0	0.00361	0	72	193										G	51773374	C	G	51773374	3	3	96	1	0	0	0	0	1	0	0	0	4595	826	29	1	3264	1	DMXL2	15	51773374	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	402	51773374	50758018	700	29176										
ONECUT1	3175	broad.mit.edu	37	chr15	53081206	53081206	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcgccacctctttggtattGatctcttccatctgccctga	7	14	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:53081206G>C	uc002aci.1	-	1	1004	c.876C>G	c.(874-876)ATC>ATG	p.I292M		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	292	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		CTTTGGTATTGATCTCTTCCA	0.627													0	0	0	0.003755	0	36	101										C	53081206	G	C	53081206	3	2	96	1	0	0	0	0	1	0	0	0	10868	1280	45	1	529	1	ONECUT1	15	53081206	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1307832	53081206	49450186	701	29177										
ALDH1A2	8854	broad.mit.edu	37	chr15	58285149	58285149	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccgtttctcttacctccttGatgagggctcccatgtagag	9	12	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:58285149G>A	uc002aex.2	-	6	736	c.678C>T	c.(676-678)ATC>ATT	p.I226I	ALDH1A2_uc002aey.2_Silent_p.I226I|ALDH1A2_uc010ugv.1_Silent_p.I205I|ALDH1A2_uc010ugw.1_Silent_p.I197I|ALDH1A2_uc002aew.2_Silent_p.I130I	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	226					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTACCTCCTTGATGAGGGCTC	0.473													0	0	0	0.00361	0	48	125										A	58285149	G	A	58285149	2	1	96	1	0	0	0	0	0	0	0	1	491	1280	45	1		1	ALDH1A2	15	58285149	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5203943	58285149	44246243	702	29178										
VPS13C	54832	broad.mit.edu	37	chr15	62283250	62283250	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcactataaccaatggcagtGaagagtttatctttttcctc	6	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:62283250G>T	uc002agz.2	-	18	1601	c.1527C>A	c.(1525-1527)TTC>TTA	p.F509L	VPS13C_uc002aha.2_Missense_Mutation_p.F466L|VPS13C_uc002ahb.1_Missense_Mutation_p.F509L|VPS13C_uc002ahc.1_Missense_Mutation_p.F466L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	509					protein localization					ovary(2)	2						CAATGGCAGTGAAGAGTTTAT	0.299													1	0	2.32416e-17	0.002299	2.93836e-17	21	97										T	62283250	G	T	62283250	3	4	96	1	0	0	0	0	1	0	0	0	17188	1281	45	3	10034	3	VPS13C	15	62283250	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3998101	62283250	40248142	703	29179										
ANKDD1A	348094	broad.mit.edu	37	chr15	65239700	65239700	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaaacacagcagctccgttCtgtgctgtggcggctggcct	14	12	1	0	rs145708523	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:65239700C>T	uc002aoa.2	+	13	1267	c.1238C>T	c.(1237-1239)TCT>TTT	p.S413F	ANKDD1A_uc002aoc.2_RNA|ANKDD1A_uc010bha.2_Missense_Mutation_p.S290F	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	413	Death.				signal transduction					ovary(1)	1						CAGCTCCGTTCTGTGCTGTGG	0.592													0	0	0	0.000978	0	9	20										T	65239700	C	T	65239700	3	4	96	1	0	0	0	0	1	0	0	0	624	913	32	1	1288	1	ANKDD1A	15	65239700	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2956450	65239700	37291692	704	29180										
NOX5	79400	broad.mit.edu	37	chr15	69325600	69325600	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcggccagtgcctcaacttcGactgcagcttcatcgcggta	11	14	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:69325600G>C	uc002ars.1	+	5	858	c.838G>C	c.(838-840)GAC>CAC	p.D280H	NOX5_uc002arp.1_Missense_Mutation_p.D262H|NOX5_uc002arq.1_Missense_Mutation_p.D234H|NOX5_uc010bid.1_Missense_Mutation_p.D245H|NOX5_uc002arr.1_Missense_Mutation_p.D252H|NOX5_uc010bie.1_Missense_Mutation_p.D80H|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	280	Helical; (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CCTCAACTTCGACTGCAGCTT	0.647													0	0	0	0.000978	0	10	40										C	69325600	G	C	69325600	3	2	96	1	0	0	0	0	1	0	0	0	10559	1058	37	1	889	1	NOX5	15	69325600	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4085900	69325600	33205792	705	29181										
LRRC49	54839	broad.mit.edu	37	chr15	71256227	71256227	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtacaaacacactgtccttCagaatatgatgcagctgcgc	9	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:71256227C>T	uc002asw.2	+	9	1124	c.877C>T	c.(877-879)CAG>TAG	p.Q293*	LRRC49_uc002asu.2_Nonsense_Mutation_p.Q283*|LRRC49_uc002asx.2_Nonsense_Mutation_p.Q249*|LRRC49_uc010ukf.1_Nonsense_Mutation_p.Q298*|LRRC49_uc002asy.2_5'UTR|LRRC49_uc002asz.2_Nonsense_Mutation_p.Q265*	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	293	LRRCT.					cytoplasm|microtubule				ovary(1)	1						CACTGTCCTTCAGAATATGAT	0.463													0	0	0	0.00361	0	59	140										T	71256227	C	T	71256227	4	4	96	1	0	0	0	0	0	1	0	0	9006	827	29	1	911	1	LRRC49	15	71256227	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1930627	71256227	31275165	706	29182										
ISLR2	57611	broad.mit.edu	37	chr15	74427127	74427127	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acgtgcagggggagggccttGatgaagacgcggagcaggga	20	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:74427127G>C	uc002axd.2	+	4	2801	c.2032G>C	c.(2032-2034)GAT>CAT	p.D678H	ISLR2_uc002axe.2_Missense_Mutation_p.D678H|ISLR2_uc010bjg.2_Missense_Mutation_p.D678H|ISLR2_uc010bjf.2_Missense_Mutation_p.D678H	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	678	Cytoplasmic (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GGAGGGCCTTGATGAAGACGC	0.667											OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.002299	0	23	52										C	74427127	G	C	74427127	3	2	96	1	0	0	0	0	1	0	0	0	7859	1290	45	1	2034	1	ISLR2	15	74427127	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3170900	74427127	28104265	707	29183										
CYP1A1	1543	broad.mit.edu	37	chr15	75014950	75014950	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggacctcagcctccttgctCacatgctcttccaggtagca	8	15	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:75014950C>T	uc002ayp.3	-	2	611	c.489G>A	c.(487-489)GTG>GTA	p.V163V	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Intron|CYP1A1_uc010bjx.2_Intron|CYP1A1_uc002ayq.3_Silent_p.V163V|CYP1A1_uc010bjy.2_Silent_p.V163V|CYP1A1_uc010bjz.1_Intron	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	163					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CCTCCTTGCTCACATGCTCTT	0.582									Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				0	0	0	0.002836	0	34	110										T	75014950	C	T	75014950	2	4	96	1	0	0	0	0	0	0	0	1	4149	813	29	1		1	CYP1A1	15	75014950	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	587823	75014950	27516442	708	29184										
CSPG4	1464	broad.mit.edu	37	chr15	75977247	75977247	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacgtagcggatcagctgctCttccacctaggggcaggccc	12	15	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:75977247C>T	uc002baw.2	-	5	4372	c.4279G>A	c.(4279-4281)GAG>AAG	p.E1427K		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1427	CSPG 9.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						ATCAGCTGCTCTTCCACCTAG	0.552													0	0	0	0.008871	0	18	62										T	75977247	C	T	75977247	3	4	96	1	0	0	0	0	1	0	0	0	3960	922	32	1	2713	1	CSPG4	15	75977247	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	962297	75977247	26554145	709	29185										
FANCI	55215	broad.mit.edu	37	chr15	89835963	89835963	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cattgtttggcctggtataaGaatacagtcatacccttaca	7	9	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:89835963G>C	uc010bnp.1	+	21	2127	c.2037G>C	c.(2035-2037)AAG>AAC	p.K679N	FANCI_uc002bnm.1_Missense_Mutation_p.K679N|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.K500N|FANCI_uc002bnq.1_Missense_Mutation_p.K92N	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	679					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CCTGGTATAAGAATACAGTCA	0.289								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00632	0	29	58										C	89835963	G	C	89835963	3	2	96	1	0	0	0	0	1	0	0	0	5669	933	33	1	2115	1	FANCI	15	89835963	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	13858716	89835963	12695429	710	29186										
FANCI	55215	broad.mit.edu	37	chr15	89836185	89836185	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttttaggataaatcagcaGatttttctcagagcaccagt	7	8	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:89836185G>C	uc010bnp.1	+	22	2272	c.2182G>C	c.(2182-2184)GAT>CAT	p.D728H	FANCI_uc002bnm.1_Missense_Mutation_p.D728H|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.D549H|FANCI_uc002bnq.1_Missense_Mutation_p.D141H	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	728					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TAAATCAGCAGATTTTTCTCA	0.328								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007291	0	29	88										C	89836185	G	C	89836185	3	2	96	1	0	0	0	0	1	0	0	0	5669	942	33	1	2264	1	FANCI	15	89836185	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	222	89836185	12695207	711	29187										
C15orf42	90381	broad.mit.edu	37	chr15	90168528	90168528	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccccctctccatttcaaacaGatggggttccttggacacca	7	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:90168528G>C	uc002boe.2	+	20	4987	c.4987G>C	c.(4987-4989)GAT>CAT	p.D1663H	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1663					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			ATTTCAAACAGATGGGGTTCC	0.592													0	0	0	0.006214	0	10	92										C	90168528	G	C	90168528	3	2	96	1	0	0	0	0	1	0	0	0	1796	942	33	1	5065	1	C15orf42	15	90168528	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	332343	90168528	12362864	712	29188										
TTLL13	440307	broad.mit.edu	37	chr15	90799463	90799463	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtcagggacgtggcatcttCattacccgaaatccccggga	11	12	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:90799463C>T	uc002bpd.1	+	6	927	c.639C>T	c.(637-639)TTC>TTT	p.F213F	TTLL13_uc002bpe.1_Intron	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	213	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GTGGCATCTTCATTACCCGAA	0.537													0	0	0	0.001855	0	10	126										T	90799463	C	T	90799463	2	4	96	1	0	0	0	0	0	0	0	1	16723	825	29	1		1	TTLL13	15	90799463	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	630935	90799463	11731929	713	29189										
NGRN	51335	broad.mit.edu	37	chr15	90808999	90808999	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcgtttgcgccgccgtcactCgctgtgggttcgcgacccgg	15	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:90808999C>T	uc002bpf.1	+	1	105	c.55C>T	c.(55-57)CGC>TGC	p.R19C	TTLL13_uc002bpe.1_Intron|NGRN_uc002bpg.1_5'UTR	NM_001033088	NP_001028260	Q9NPE2	NGRN_HUMAN	neugrin	19					neuron differentiation	extracellular region|nucleus				large_intestine(2)|ovary(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			CGCCGTCACTCGCTGTGGGTT	0.692													0	0	0	0.00245	0	12	36										T	90808999	C	T	90808999	3	4	96	1	0	0	0	0	1	0	0	0	10399	884	31	1	57	1	NGRN	15	90808999	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9536	90808999	11722393	714	29190										
MAN2A2	4122	broad.mit.edu	37	chr15	91456191	91456191	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgcgtactatgagcacattCaccaggcggtccggctttac	10	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:91456191C>A	uc010bnz.2	+	17	2669	c.2554C>A	c.(2554-2556)CAC>AAC	p.H852N	MAN2A2_uc002bqc.2_Missense_Mutation_p.H852N|MAN2A2_uc010uql.1_Missense_Mutation_p.H514N|MAN2A2_uc010uqm.1_Missense_Mutation_p.H431N|MAN2A2_uc010uqn.1_RNA	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	852					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TGAGCACATTCACCAGGCGGT	0.567													1	0	1.10923e-09	0.00278	1.36521e-09	23	65										A	91456191	C	A	91456191	3	1	96	1	0	0	0	0	1	0	0	0	9215	826	29	3	2616	3	MAN2A2	15	91456191	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	647192	91456191	11075201	715	29191										
LRRK1	79705	broad.mit.edu	37	chr15	101588736	101588736	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaatactaaaagcaggaacaGgaaagtcaccatttacagtt	8	7	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:101588736G>A	uc002bwr.2	+	22	3492	c.3173G>A	c.(3172-3174)AGG>AAG	p.R1058K	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_Intron	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1058					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGCAGGAACAGGAAAGTCACC	0.448													0	0	0	0.004656	0	26	108										A	101588736	G	A	101588736	3	1	96	1	0	0	0	0	1	0	0	0	9032	1000	35	2	3255	2	LRRK1	15	101588736	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10132545	101588736	942656	716	29192										
LRRK1	79705	broad.mit.edu	37	chr15	101601442	101601442	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggatgtgctgccctgggatGaaggtgagctgccagctcca	15	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:101601442G>A	uc002bwr.2	+	30	5065	c.4746G>A	c.(4744-4746)ATG>ATA	p.M1582I	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1582					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GCCCTGGGATGAAGGTGAGCT	0.612													0	0	0	0.00245	0	13	41										A	101601442	G	A	101601442	3	1	96	1	0	0	0	0	1	0	0	0	9032	1290	45	1	4860	1	LRRK1	15	101601442	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	12706	101601442	929950	717	29193										
CHSY1	22856	broad.mit.edu	37	chr15	101718818	101718818	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctgggcggagtccattcctCttcgagggggctggccgtca	15	12	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:101718818C>T	uc002bwt.1	-	4	1667	c.1184G>A	c.(1183-1185)AGA>AAA	p.R395K	CHSY1_uc010usd.1_Missense_Mutation_p.R123K	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	395	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTCCATTCCTCTTCGAGGGGG	0.542													0	0	0	0.004289	0	35	73										T	101718818	C	T	101718818	3	4	96	1	0	0	0	0	1	0	0	0	3412	913	32	1	1228	1	CHSY1	15	101718818	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	117376	101718818	812574	718	29194										
TARSL2	123283	broad.mit.edu	37	chr15	102255153	102255153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttggctattaccgtgctttCagccagttcctgactaagaa	8	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr15:102255153C>G	uc002bxm.2	-	4	635	c.580G>C	c.(580-582)GAA>CAA	p.E194Q	TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	194					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACCGTGCTTTCAGCCAGTTCC	0.403													0	0	0	0.001368	0	11	62										G	102255153	C	G	102255153	3	3	96	1	0	0	0	0	1	0	0	0	15558	835	29	1	1892	1	TARSL2	15	102255153	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	536335	102255153	276239	719	29195										
STUB1	10273	broad.mit.edu	37	chr16	731803	731803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caacccccagggagctggaaGagtgccagcgaaaccacgag	13	13	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:731803G>C	uc002cit.2	+	4	946	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	STUB1_uc002ciu.2_Missense_Mutation_p.E107Q|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	179					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				GGAGCTGGAAGAGTGCCAGCG	0.627													0	0	0	0.001882	0	21	55										C	731803	G	C	731803	3	2	96	1	0	0	0	0	1	0	0	0	15334	943	33	1	549	1	STUB1	16	731803	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		731803	89622950	720	29196										
HN1L	90861	broad.mit.edu	37	chr16	1741917	1741917	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacctgaacccacctggaggGaagaccagcgacatttttgg	11	12	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:1741917G>A	uc002cmg.2	+	3	303	c.267G>A	c.(265-267)GGG>GGA	p.G89G	HN1L_uc010uvi.1_Silent_p.G117G|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_Intron|HN1L_uc010uvj.1_Intron|HN1L_uc010uvk.1_Silent_p.G76G	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	89						cytoplasm|nucleus				upper_aerodigestive_tract(1)	1						CACCTGGAGGGAAGACCAGCG	0.542													0	0	0	0.007413	0	16	74										A	1741917	G	A	1741917	2	1	96	1	0	0	0	0	0	0	0	1	7250	1161	41	1		1	HN1L	16	1741917	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1010114	1741917	88612836	721	29197										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1810466	1810466	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggtgctgaggggcgagttgGaggctgctaagcaggccaaa	18	7	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:1810466G>C	uc002cmk.2	+	12	1507	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	MAPK8IP3_uc002cml.2_Missense_Mutation_p.E457Q|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.E464Q	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	463	Potential.				vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GGGCGAGTTGGAGGCTGCTAA	0.537													0	0	0	0.005524	0	37	89										C	1810466	G	C	1810466	3	2	96	1	0	0	0	0	1	0	0	0	9286	1175	41	1	1449	1	MAPK8IP3	16	1810466	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	68549	1810466	88544287	722	29198										
PDPK1	5170	broad.mit.edu	37	chr16	2647748	2647748	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcagcgataccagagccacCcggacgccgctgtgcagtga	14	14	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:2647748C>G	uc002cqs.2	+	14	1795	c.1651C>G	c.(1651-1653)CCG>GCG	p.P551A	PDPK1_uc002cqt.2_Missense_Mutation_p.P424A|PDPK1_uc010bsn.2_3'UTR|PDPK1_uc002cqu.2_Missense_Mutation_p.P524A	NM_002613	NP_002604	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	551					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|ovary(1)	3		Ovarian(90;0.17)			Celecoxib(DB00482)	CCAGAGCCACCCGGACGCCGC	0.662													0	0	0	0.00245	0	14	35										G	2647748	C	G	2647748	3	3	96	1	0	0	0	0	1	0	0	0	11687	623	22	4	1705	4	PDPK1	16	2647748	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	837282	2647748	87707005	723	29199										
THOC6	79228	broad.mit.edu	37	chr16	3077242	3077242	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccaccaccatcttccccatCcgggcgccacagaagcacgt	7	20	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:3077242C>T	uc002ctb.2	+	11	1067	c.771C>T	c.(769-771)ATC>ATT	p.I257I	HCFC1R1_uc002csx.1_5'Flank|HCFC1R1_uc002csy.1_5'Flank|HCFC1R1_uc002csz.1_5'Flank|THOC6_uc002ctd.2_Silent_p.I257I|THOC6_uc002ctc.2_Silent_p.I233I|THOC6_uc002cta.2_Silent_p.I233I	NM_024339	NP_077315	Q86W42	THOC6_HUMAN	WD repeat domain 58 isoform 1	257	WD 6.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			ovary(1)|central_nervous_system(1)	2						TCTTCCCCATCCGGGCGCCAC	0.637													0	0	0	0.004289	0	38	87										T	3077242	C	T	3077242	2	4	96	1	0	0	0	0	0	0	0	1	15866	845	30	1		1	THOC6	16	3077242	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	429494	3077242	87277511	724	29200										
CREBBP	1387	broad.mit.edu	37	chr16	3777746	3777746	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccctccacaaacttctctagCgtgtcccccgtggtgtcccc	7	19	1	0	rs144609433	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:3777746C>T	uc002cvv.2	-	31	7506	c.7302G>A	c.(7300-7302)ACG>ACA	p.T2434T	CREBBP_uc002cvw.2_Silent_p.T2396T	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	2434					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACTTCTCTAGCGTGTCCCCCG	0.552			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.00361	0	66	131										T	3777746	C	T	3777746	2	4	96	1	0	0	0	0	0	0	0	1	3861	755	27	2		2	CREBBP	16	3777746	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	700504	3777746	86577007	725	29201										
GSPT1	2935	broad.mit.edu	37	chr16	11980398	11980398	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcctgagcagggcataaagtGaatgtcctttttgggattga	12	6	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:11980398G>A	uc002dbr.2	-	7	796	c.769C>T	c.(769-771)CAC>TAC	p.H257Y	GSPT1_uc002dbu.2_Missense_Mutation_p.H394Y|GSPT1_uc002dbt.2_Missense_Mutation_p.H395Y|GSPT1_uc010bux.2_Missense_Mutation_p.H257Y	NM_001130007	NP_001123479	P15170	ERF3A_HUMAN	G1 to S phase transition 1 isoform 3	257					G1/S transition of mitotic cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation	intracellular	GTP binding|GTPase activity|protein binding|translation release factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GGCATAAAGTGAATGTCCTTT	0.348													0	0	0	0.002299	0	24	64										A	11980398	G	A	11980398	3	1	96	1	0	0	0	0	1	0	0	0	6826	1290	45	1	758	1	GSPT1	16	11980398	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	8202652	11980398	78374355	726	29202										
NOMO1	23420	broad.mit.edu	37	chr16	14951394	14951394	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgatggctcattccgccttGagaacataaccacagggaca	9	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:14951394G>C	uc002dcv.2	+	11	1168	c.1102G>C	c.(1102-1104)GAG>CAG	p.E368Q		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	368	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						ATTCCGCCTTGAGAACATAAC	0.428													0	0	0	0.006999	0	29	73										C	14951394	G	C	14951394	3	2	96	1	0	0	0	0	1	0	0	0	10531	1291	45	1	1144	1	NOMO1	16	14951394	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2970996	14951394	75403359	727	29203										
KIAA0430	9665	broad.mit.edu	37	chr16	15718772	15718772	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctggtaacacttcgggcactGaggttctcctttctaacaga	9	11	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:15718772G>C	uc002ddr.2	-	10	2317	c.2124C>G	c.(2122-2124)CTC>CTG	p.L708L	KIAA0430_uc002ddq.2_Silent_p.L564L|KIAA0430_uc010uzv.1_Silent_p.L704L|KIAA0430_uc010uzw.1_Silent_p.L706L	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	707						peroxisome	nucleotide binding|RNA binding				0						TTCGGGCACTGAGGTTCTCCT	0.408													0	0	0	0.002445	0	32	66										C	15718772	G	C	15718772	2	2	96	1	0	0	0	0	0	0	0	1	8177	1277	45	1		1	KIAA0430	16	15718772	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	767378	15718772	74635981	728	29204										
SMG1	23049	broad.mit.edu	37	chr16	18856931	18856931	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcaaatacgatgggcttcatCaaagctgtgtgcttctccct	9	11	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:18856931C>G	uc002dfm.2	-	39	6402	c.6039G>C	c.(6037-6039)TTG>TTC	p.L2013F	SMG1_uc010bwb.2_Missense_Mutation_p.L1873F|SMG1_uc010bwa.2_Missense_Mutation_p.L744F|SMG1_uc002dfo.3_Missense_Mutation_p.L311F	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2013					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGGGCTTCATCAAAGCTGTGT	0.388													0	0	0	0.003755	0	32	150										G	18856931	C	G	18856931	3	3	96	1	0	0	0	0	1	0	0	0	14795	825	29	1	5046	1	SMG1	16	18856931	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3138159	18856931	71497822	729	29205										
C16orf88	400506	broad.mit.edu	37	chr16	19726086	19726086	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgggtgacttctctgtccgtCtagcaggcagcgtggtctca	13	11	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:19726086C>G	uc002dgq.2	-	2	287	c.272G>C	c.(271-273)AGA>ACA	p.R91T	IQCK_uc002dgr.2_5'Flank|IQCK_uc002dgs.2_5'Flank|IQCK_uc010vat.1_5'Flank|IQCK_uc010bwc.2_5'Flank|IQCK_uc010vau.1_5'Flank	NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	91	Lys-rich.					nucleolus					0						CTCTGTCCGTCTAGCAGGCAG	0.473													0	0	0	0.006122	0	17	92										G	19726086	C	G	19726086	3	3	96	1	0	0	0	0	1	0	0	0	1841	913	32	1	1120	1	C16orf88	16	19726086	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	869155	19726086	70628667	730	29206										
DNAH3	55567	broad.mit.edu	37	chr16	21132097	21132097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agccgcgtgcatgctgggctCtcctggctcagctgctttca	12	14	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:21132097C>G	uc010vbe.1	-	11	1663	c.1663G>C	c.(1663-1665)GAG>CAG	p.E555Q	DNAH3_uc002die.2_Intron	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	555	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATGCTGGGCTCTCCTGGCTCA	0.507													0	0	0	0.004007	0	15	38										G	21132097	C	G	21132097	3	3	96	1	0	0	0	0	1	0	0	0	4603	922	32	1	10894	1	DNAH3	16	21132097	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1406011	21132097	69222656	731	29207										
VWA3A	146177	broad.mit.edu	37	chr16	22157565	22157565	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccttaacccagggagtggtGagacacatccagtggacgcc	13	12	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:22157565G>C	uc010vbq.1	+	27	2835	c.2739G>C	c.(2737-2739)GTG>GTC	p.V913V	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_5'UTR|VWA3A_uc010bxe.1_5'UTR	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	913						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		AGGGAGTGGTGAGACACATCC	0.532													0	0	0	0.008291	0	10	24										C	22157565	G	C	22157565	2	2	96	1	0	0	0	0	0	0	0	1	17237	1277	45	1		1	VWA3A	16	22157565	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1025468	22157565	68197188	732	29208										
USP31	57478	broad.mit.edu	37	chr16	23096215	23096215	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtacagttggaaacactggGataaagtgcaggtttgaggc	14	5	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:23096215G>A	uc002dll.2	-	11	1796	c.1796C>T	c.(1795-1797)TCC>TTC	p.S599F	USP31_uc010bxm.2_5'UTR	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	599					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		GAAACACTGGGATAAAGTGCA	0.488													0	0	0	0.00361	0	114	280										A	23096215	G	A	23096215	3	1	96	1	0	0	0	0	1	0	0	0	17059	1174	41	1	2286	1	USP31	16	23096215	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	938650	23096215	67258538	733	29209										
TNRC6A	27327	broad.mit.edu	37	chr16	24801938	24801938	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccacatctcagacaaatgagCaaagcagtgtgtgggccaaa	10	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:24801938C>G	uc002dmm.2	+	6	2089	c.1975C>G	c.(1975-1977)CAA>GAA	p.Q659E	TNRC6A_uc010bxs.2_Missense_Mutation_p.Q406E|TNRC6A_uc010vcc.1_Missense_Mutation_p.Q406E|TNRC6A_uc002dmn.2_Missense_Mutation_p.Q406E|TNRC6A_uc002dmo.2_Missense_Mutation_p.Q406E	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	659	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GACAAATGAGCAAAGCAGTGT	0.468													0	0	0	0.006122	0	19	52										G	24801938	C	G	24801938	3	3	96	1	0	0	0	0	1	0	0	0	16337	711	25	4	1997	4	TNRC6A	16	24801938	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1705723	24801938	65552815	734	29210										
TNRC6A	27327	broad.mit.edu	37	chr16	24802034	24802034	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaaaaggaactggggaaagtCagagtagagacagaagaaaa	13	3	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:24802034C>T	uc002dmm.2	+	6	2185	c.2071C>T	c.(2071-2073)CAG>TAG	p.Q691*	TNRC6A_uc010bxs.2_Nonsense_Mutation_p.Q438*|TNRC6A_uc010vcc.1_Nonsense_Mutation_p.Q438*|TNRC6A_uc002dmn.2_Nonsense_Mutation_p.Q438*|TNRC6A_uc002dmo.2_Nonsense_Mutation_p.Q438*	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	691	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGGGGAAAGTCAGAGTAGAGA	0.473													0	0	0	0.00278	0	23	55										T	24802034	C	T	24802034	4	4	96	1	0	0	0	0	0	1	0	0	16337	827	29	1	2093	1	TNRC6A	16	24802034	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	96	24802034	65552719	735	29211										
SULT1A2	6799	broad.mit.edu	37	chr16	28603594	28603594	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggcacctacctttcctcatGaagggggagatgctgtggtc	13	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:28603594G>A	uc002dqg.1	-	7	1116	c.765C>T	c.(763-765)TTC>TTT	p.F255F	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Silent_p.F255F	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	255					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						CTTTCCTCATGAAGGGGGAGA	0.602													0	0	0	0.00361	0	45	152										A	28603594	G	A	28603594	2	1	96	1	0	0	0	0	0	0	0	1	15372	1281	45	1		1	SULT1A2	16	28603594	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3801560	28603594	61751159	736	29212										
SRCAP	10847	broad.mit.edu	37	chr16	30723652	30723652	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcacattgggctagactggCtggttaccatgtatgagaag	13	7	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:30723652C>G	uc002dze.1	+	13	2270	c.1885C>G	c.(1885-1887)CTG>GTG	p.L629V	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.L486V|SRCAP_uc010bzz.1_Missense_Mutation_p.L199V	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	629					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCTAGACTGGCTGGTTACCAT	0.522													0	0	0	0.001168	0	6	155										G	30723652	C	G	30723652	3	3	96	1	0	0	0	0	1	0	0	0	15134	796	28	4	1927	4	SRCAP	16	30723652	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2120058	30723652	59631101	737	29213										
ZNF668	79759	broad.mit.edu	37	chr16	31075325	31075325	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtggatcttgagcttggaGagcgcgccataggccttcgg	16	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:31075325G>A	uc010caf.2	-	2	813	c.456C>T	c.(454-456)CTC>CTT	p.L152L	ZNF668_uc002eao.2_Silent_p.L152L|ZNF668_uc010cag.1_Silent_p.L152L	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	152	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						TGAGCTTGGAGAGCGCGCCAT	0.672													0	0	0	0.001368	0	11	16										A	31075325	G	A	31075325	2	1	96	1	0	0	0	0	0	0	0	1	18072	929	33	1		1	ZNF668	16	31075325	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	351673	31075325	59279428	738	29214										
SLC5A2	6524	broad.mit.edu	37	chr16	31500575	31500575	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctgcggcgtgcactacctCtacttcgccattgtgctgtt	9	14	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:31500575C>G	uc002ecf.3	+	12	1600	c.1581C>G	c.(1579-1581)CTC>CTG	p.L527L	SLC5A2_uc010car.2_RNA|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	527	Helical; (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						TGCACTACCTCTACTTCGCCA	0.642													0	0	0	0.001855	0	13	43										G	31500575	C	G	31500575	2	3	96	1	0	0	0	0	0	0	0	1	14665	900	32	1		1	SLC5A2	16	31500575	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	425250	31500575	58854178	739	29215										
ABCC11	85320	broad.mit.edu	37	chr16	48237196	48237196	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgattcagggagcagcagtgGagcacctggaggtatctgtg	16	8	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:48237196G>C	uc002eff.1	-	13	2171	c.1821C>G	c.(1819-1821)CTC>CTG	p.L607L	ABCC11_uc002efg.1_Silent_p.L607L|ABCC11_uc002efh.1_Silent_p.L607L|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	607	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AGCAGCAGTGGAGCACCTGGA	0.582									Cerumen_Type				0	0	0	0.006214	0	8	10										C	48237196	G	C	48237196	2	2	96	1	0	0	0	0	0	0	0	1	51	1161	41	1		1	ABCC11	16	48237196	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	16736621	48237196	42117557	740	29216										
LONP2	83752	broad.mit.edu	37	chr16	48329968	48329968	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ataacttcacagatcattatCtaaatgtggcctttgacctt	5	9	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:48329968C>T	uc002efi.1	+	9	1515	c.1426C>T	c.(1426-1428)CTA>TTA	p.L476L	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Silent_p.L432L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	476					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						AGATCATTATCTAAATGTGGC	0.393													0	0	0	0.00361	0	61	167										T	48329968	C	T	48329968	2	4	96	1	0	0	0	0	0	0	0	1	8893	912	32	1		1	LONP2	16	48329968	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	92772	48329968	42024785	741	29217										
N4BP1	9683	broad.mit.edu	37	chr16	48595368	48595368	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cactgtaccagctgaaaattCtctgtcttcttggaatcttt	6	10	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:48595368C>G	uc002efp.2	-	2	1423	c.1186G>C	c.(1186-1188)GAA>CAA	p.E396Q		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	396					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				GCTGAAAATTCTCTGTCTTCT	0.348													0	0	0	0.002299	0	23	47										G	48595368	C	G	48595368	3	3	96	1	0	0	0	0	1	0	0	0	10109	922	32	1	1528	1	N4BP1	16	48595368	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	265400	48595368	41759385	742	29218										
CHD9	80205	broad.mit.edu	37	chr16	53338321	53338321	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagaatctagttctgattctGactcagattctgagagatca	8	8	6	6			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:53338321G>C	uc002ehb.2	+	30	6567	c.6403G>C	c.(6403-6405)GAC>CAC	p.D2135H	CHD9_uc002egy.2_Missense_Mutation_p.D2135H|CHD9_uc002ehc.2_Missense_Mutation_p.D2135H|CHD9_uc002ehf.2_Missense_Mutation_p.D1249H|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_Missense_Mutation_p.D141H	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2135	Ser-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TTCTGATTCTGACTCAGATTC	0.438													0	0	0	0.001984	0	6	20										C	53338321	G	C	53338321	3	2	96	1	0	0	0	0	1	0	0	0	3332	1290	45	1	6521	1	CHD9	16	53338321	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4742953	53338321	37016432	743	29219										
CHD9	80205	broad.mit.edu	37	chr16	53352139	53352139	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttagagaatgcagcttcatGagggaagacccaaacaaaaa	9	7	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:53352139G>A	uc002ehb.2	+	36	7764	c.7600G>A	c.(7600-7602)GAG>AAG	p.E2534K	CHD9_uc002egy.2_Missense_Mutation_p.E2518K|CHD9_uc002ehc.2_Missense_Mutation_p.E2519K|CHD9_uc002ehf.2_Missense_Mutation_p.E1632K|CHD9_uc010cbw.2_Missense_Mutation_p.E600K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2534					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GCAGCTTCATGAGGGAAGACC	0.338													0	0	0	0.001368	0	12	33										A	53352139	G	A	53352139	3	1	96	1	0	0	0	0	1	0	0	0	3332	1291	45	1	7694	1	CHD9	16	53352139	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	13818	53352139	37002614	744	29220										
RBL2	5934	broad.mit.edu	37	chr16	53498194	53498194	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttggcctgctgccttgaggtCgtcactttttcttataagcc	9	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:53498194C>G	uc002ehi.3	+	12	1735	c.1617C>G	c.(1615-1617)GTC>GTG	p.V539V	RBL2_uc010vgv.1_Silent_p.V465V|RBL2_uc002ehj.2_Silent_p.V249V|RBL2_uc010vgw.1_Silent_p.V323V	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	539	Domain A.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GCCTTGAGGTCGTCACTTTTT	0.323													0	0	0	0.004672	0	3	54										G	53498194	C	G	53498194	2	3	96	1	0	0	0	0	0	0	0	1	13110	871	31	1		1	RBL2	16	53498194	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	146055	53498194	36856559	745	29221										
IRX5	10265	broad.mit.edu	37	chr16	54967645	54967645	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccacaaccggtccggggtctCatttcaatggattaaaccag	9	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:54967645C>T	uc002ehv.2	+	3	1312	c.1312C>T	c.(1312-1314)CAT>TAT	p.H438Y	IRX5_uc002ehw.2_Missense_Mutation_p.H372Y	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	438					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						TCCGGGGTCTCATTTCAATGG	0.592													0	0	0	0.008361	0	31	88										T	54967645	C	T	54967645	3	4	96	1	0	0	0	0	1	0	0	0	7847	826	29	1	1322	1	IRX5	16	54967645	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1469451	54967645	35387108	746	29222										
CCDC135	84229	broad.mit.edu	37	chr16	57732921	57732921	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcttcctgcaccccctgaaCgagtgtgaagtgcccgtaag	10	14	1	2	rs116591936	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:57732921C>T	uc002emi.2	+	3	452	c.363C>T	c.(361-363)AAC>AAT	p.N121N	CCDC135_uc002emj.2_Silent_p.N121N|CCDC135_uc002emk.2_Silent_p.N121N	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	121						cytoplasm				central_nervous_system(1)	1						ACCCCCTGAACGAGTGTGAAG	0.647													0	0	0	0.001786	0	29	219										T	57732921	C	T	57732921	2	4	96	1	0	0	0	0	0	0	0	1	2769	535	19	2		2	CCDC135	16	57732921	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2765276	57732921	32621832	747	29223										
CNGB1	1258	broad.mit.edu	37	chr16	57957231	57957231	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caaccactggggactctgctGgtgacaacgccttgagctct	11	13	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:57957231G>C	uc002emt.2	-	18	1654	c.1589C>G	c.(1588-1590)CCA>CGA	p.P530R	CNGB1_uc010cdh.2_Missense_Mutation_p.P524R	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	530	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						GGACTCTGCTGGTGACAACGC	0.582													0	0	0	0.001984	0	6	83										C	57957231	G	C	57957231	3	2	96	1	0	0	0	0	1	0	0	0	3600	1348	47	4	2230	4	CNGB1	16	57957231	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	224310	57957231	32397522	748	29224										
PRSS54	221191	broad.mit.edu	37	chr16	58319877	58319877	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catcctgacacccagcagttCtgcaagactggtggtgtatg	11	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:58319877C>T	uc002enf.2	-	5	881	c.486G>A	c.(484-486)CAG>CAA	p.Q162Q	PRSS54_uc002eng.2_Silent_p.Q162Q|PRSS54_uc010vie.1_Silent_p.Q63Q	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	162	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCCAGCAGTTCTGCAAGACTG	0.547													0	0	0	0.005443	0	28	77										T	58319877	C	T	58319877	2	4	96	1	0	0	0	0	0	0	0	1	12633	912	32	1		1	PRSS54	16	58319877	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	362646	58319877	32034876	749	29225										
CNOT1	23019	broad.mit.edu	37	chr16	58621270	58621270	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcttgtactttgcttaatttGagcactttactcagctgggc	8	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:58621270G>C	uc002env.2	-	5	650	c.357C>G	c.(355-357)CTC>CTG	p.L119L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L119L|CNOT1_uc002enx.2_Silent_p.L119L|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	119					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGCTTAATTTGAGCACTTTAC	0.323													0	0	0	0.006122	0	15	118										C	58621270	G	C	58621270	2	2	96	1	0	0	0	0	0	0	0	1	3617	1277	45	1		1	CNOT1	16	58621270	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	301393	58621270	31733483	750	29226										
CDH5	1003	broad.mit.edu	37	chr16	66426236	66426236	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaaaaccagaagaagcctctGattggcacagtgctggccat	11	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:66426236G>C	uc002eom.3	+	7	1323	c.1167G>C	c.(1165-1167)CTG>CTC	p.L389L	CDH5_uc002eon.1_Silent_p.L389L	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	389	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGAAGCCTCTGATTGGCACAG	0.537													0	0	0	0.006999	0	41	120										C	66426236	G	C	66426236	2	2	96	1	0	0	0	0	0	0	0	1	3113	1277	45	1		1	CDH5	16	66426236	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	7804966	66426236	23928517	751	29227										
GFOD2	81577	broad.mit.edu	37	chr16	67709505	67709505	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcatgttgaagttgagtgtCactgtgctacacacaccccc	10	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:67709505C>T	uc002eub.2	-	3	1006	c.711G>A	c.(709-711)GTG>GTA	p.V237V	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Silent_p.V132V	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	237						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		AGTTGAGTGTCACTGTGCTAC	0.587													0	0	0	0.001523	0	22	60										T	67709505	C	T	67709505	2	4	96	1	0	0	0	0	0	0	0	1	6344	813	29	1		1	GFOD2	16	67709505	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1283269	67709505	22645248	752	29228										
EDC4	23644	broad.mit.edu	37	chr16	67918030	67918030	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcctcatgctgcatggcctCgtgacccccagcctccctta	8	18	1	1	rs142793660	byFrequency	TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:67918030C>T	uc002eur.2	+	29	4351	c.4185C>T	c.(4183-4185)CTC>CTT	p.L1395L	EDC4_uc010cer.2_Silent_p.L1014L|EDC4_uc002eus.2_Silent_p.L1125L|EDC4_uc002eut.1_3'UTR|NRN1L_uc002euu.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	1395					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		TGCATGGCCTCGTGACCCCCA	0.627											OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	11	20										T	67918030	C	T	67918030	2	4	96	1	0	0	0	0	0	0	0	1	4908	871	31	1		1	EDC4	16	67918030	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	208525	67918030	22436723	753	29229										
PLA2G15	23659	broad.mit.edu	37	chr16	68293167	68293167	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtcacctgagaaggtgttCgtgcagacacccacaatcaa	10	11	2	2	rs142263893		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:68293167C>T	uc002evr.2	+	6	929	c.846C>T	c.(844-846)TTC>TTT	p.F282F	PLA2G15_uc010vld.1_3'UTR|PLA2G15_uc010vle.1_Silent_p.F188F|PLA2G15_uc010vlf.1_Silent_p.F82F|PLA2G15_uc002evs.2_Silent_p.F103F	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	282					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						AGAAGGTGTTCGTGCAGACAC	0.577													0	0	0	0.001523	0	21	64										T	68293167	C	T	68293167	2	4	96	1	0	0	0	0	0	0	0	1	11992	883	31	1		1	PLA2G15	16	68293167	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	375137	68293167	22061586	754	29230										
SF3B3	23450	broad.mit.edu	37	chr16	70589022	70589022	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagtggaagacccctggaaaGaaaacaattgtgaagtgtgc	13	6	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:70589022G>C	uc002ezf.2	+	13	1834	c.1623G>C	c.(1621-1623)AAG>AAC	p.K541N		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	541					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CCCCTGGAAAGAAAACAATTG	0.453													0	0	0	0.003214	0	46	93										C	70589022	G	C	70589022	3	2	96	1	0	0	0	0	1	0	0	0	14152	933	33	1	1669	1	SF3B3	16	70589022	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2295855	70589022	19765731	755	29231										
HYDIN	54768	broad.mit.edu	37	chr16	70843806	70843806	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaagtgctggcgtggctttCagatagagctcatattggta	14	6	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:70843806C>T	uc002ezr.2	-	85	14888	c.14760G>A	c.(14758-14760)CTG>CTA	p.L4920L	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4921										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GCGTGGCTTTCAGATAGAGCT	0.468													0	0	0	0.00361	0	196	479										T	70843806	C	T	70843806	2	4	96	1	0	0	0	0	0	0	0	1	7467	813	29	1		1	HYDIN	16	70843806	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	254784	70843806	19510947	756	29232										
CHST4	10164	broad.mit.edu	37	chr16	71571634	71571634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacttcagaaagcctgtggcGatgccatgaatttgctgggc	13	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:71571634G>A	uc002fan.2	+	2	1235	c.1054G>A	c.(1054-1056)GAT>AAT	p.D352N	CHST4_uc002fao.2_Missense_Mutation_p.D352N	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	352	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGCCTGTGGCGATGCCATGAA	0.512											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	14	77										A	71571634	G	A	71571634	3	1	96	1	0	0	0	0	1	0	0	0	3406	1058	37	1	1056	1	CHST4	16	71571634	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	727828	71571634	18783119	757	29233										
PMFBP1	83449	broad.mit.edu	37	chr16	72156877	72156877	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagctggtttcctagtttctCattggcgaccctgtaataaa	9	9	1	0	rs145484256		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:72156877C>T	uc002fcc.3	-	19	2891	c.2719G>A	c.(2719-2721)GAG>AAG	p.E907K	PMFBP1_uc002fcd.2_Missense_Mutation_p.E902K|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.E757K	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	907										ovary(2)	2		Ovarian(137;0.179)				CCTAGTTTCTCATTGGCGACC	0.532													0	0	0	0.004656	0	25	80										T	72156877	C	T	72156877	3	4	96	1	0	0	0	0	1	0	0	0	12134	835	29	1	391	1	PMFBP1	16	72156877	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	585243	72156877	18197876	758	29234										
MLKL	197259	broad.mit.edu	37	chr16	74706420	74706420	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cactacttagaaaaggtggaGagtttctttaagatttctgt	9	5	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:74706420G>C	uc002fdb.2	-	11	1839	c.1398C>G	c.(1396-1398)CTC>CTG	p.L466L	MLKL_uc002fdc.2_Silent_p.L258L	NM_152649	NP_689862	Q8NB16	MLKL_HUMAN	mixed lineage kinase domain-like isoform 1	466	Protein kinase.						ATP binding|protein binding|protein kinase activity			stomach(2)	2						AAAAGGTGGAGAGTTTCTTTA	0.408													0	0	0	0.00361	0	53	160										C	74706420	G	C	74706420	2	2	96	1	0	0	0	0	0	0	0	1	9619	929	33	1		1	MLKL	16	74706420	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2549543	74706420	15648333	759	29235										
WDR59	79726	broad.mit.edu	37	chr16	74920244	74920244	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actcccaaagcggagctcttCtggtgaggattctccccaag	10	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:74920244C>A	uc002fdh.1	-	24	2572	c.2470G>T	c.(2470-2472)GAA>TAA	p.E824*	WDR59_uc002fdf.1_Nonsense_Mutation_p.E269*|WDR59_uc002fdg.1_Nonsense_Mutation_p.E416*	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	824										ovary(1)|breast(1)	2						CGGAGCTCTTCTGGTGAGGAT	0.527													1	0	6.53348e-20	0.003755	8.28917e-20	35	86										A	74920244	C	A	74920244	4	1	96	1	0	0	0	0	0	1	0	0	17305	922	32	3	466	3	WDR59	16	74920244	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	213824	74920244	15434509	760	29236										
VAT1L	57687	broad.mit.edu	37	chr16	77822778	77822778	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaaggccatgcccgagcctCaggacggcgagctcaagatc	14	13	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:77822778C>G	uc002ffg.1	+	1	296	c.199C>G	c.(199-201)CAG>GAG	p.Q67E		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	67							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GCCCGAGCCTCAGGACGGCGA	0.672													0	0	0	0.001984	0	6	13										G	77822778	C	G	77822778	3	3	96	1	0	0	0	0	1	0	0	0	17127	827	29	1	201	1	VAT1L	16	77822778	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2902534	77822778	12531975	761	29237										
PLCG2	5336	broad.mit.edu	37	chr16	81960752	81960752	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caactacgtcgaggacatctCaactgcagacttcgaggagc	10	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:81960752C>G	uc002fgt.2	+	23	2635	c.2483C>G	c.(2482-2484)TCA>TGA	p.S828*		NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	828	SH3.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GAGGACATCTCAACTGCAGAC	0.527													0	0	0	0.00361	0	59	144										G	81960752	C	G	81960752	4	3	96	1	0	0	0	0	0	1	0	0	12036	838	29	1	2569	1	PLCG2	16	81960752	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4137974	81960752	8394001	762	29238										
MPHOSPH6	10200	broad.mit.edu	37	chr16	82197748	82197748	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcactaatgattttcttttCttcttcttctagttgtttct	3	8	7	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:82197748C>T	uc002fgw.2	-	2	152	c.103G>A	c.(103-105)GAA>AAA	p.E35K		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	35	Poly-Glu.				M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						ATTTTCTTTTCTTCTTCTTCT	0.353													0	0	0	0.00278	0	22	58										T	82197748	C	T	82197748	3	4	96	1	0	0	0	0	1	0	0	0	9726	922	32	1	395	1	MPHOSPH6	16	82197748	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	236996	82197748	8157005	763	29239										
KIAA0513	9764	broad.mit.edu	37	chr16	85120761	85120761	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagcaggctgtgattggcaAcctggatgaaggtgcgtctg	16	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:85120761A>G	uc002fiu.2	+	12	1395	c.1175A>G	c.(1174-1176)AAC>AGC	p.N392S	KIAA0513_uc010voj.1_Missense_Mutation_p.N382S	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	392						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		GTGATTGGCAACCTGGATGAA	0.602											OREG0023994	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	14	51										G	85120761	A	G	85120761	3	3	96	1	0	0	0	0	1	0	0	0	8181	43	2	5	1217	5	KIAA0513	16	85120761	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	2923013	85120761	5233992	764	29240										
IL17C	27189	broad.mit.edu	37	chr16	88706324	88706324	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggccgcgagacagctgcgctCaactccgtgcggctgctcca	13	16	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:88706324C>G	uc002fla.2	+	3	487	c.438C>G	c.(436-438)CTC>CTG	p.L146L		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	146					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		CAGCTGCGCTCAACTCCGTGC	0.687													0	0	0	0.000978	0	12	25										G	88706324	C	G	88706324	2	3	96	1	0	0	0	0	0	0	0	1	7636	813	29	1		1	IL17C	16	88706324	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3585563	88706324	1648429	765	29241										
IL17C	27189	broad.mit.edu	37	chr16	88706361	88706361	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccagagcctgctggtgctgCgccgccggccctgctcccgc	13	19	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:88706361C>T	uc002fla.2	+	3	524	c.475C>T	c.(475-477)CGC>TGC	p.R159C		NM_013278	NP_037410	Q9P0M4	IL17C_HUMAN	interleukin 17C precursor	159					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)		GCTGGTGCTGCGCCGCCGGCC	0.701													0	0	0	0.00499	0	17	38										T	88706361	C	T	88706361	3	4	96	1	0	0	0	0	1	0	0	0	7636	768	27	2	485	2	IL17C	16	88706361	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	37	88706361	1648392	766	29242										
SPG7	6687	broad.mit.edu	37	chr16	89611106	89611106	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggcgtccacgaaccgagctGacattttggacggtgctctg	13	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:89611106G>T	uc002fnj.2	+	10	1396	c.1375G>T	c.(1375-1377)GAC>TAC	p.D459Y	SPG7_uc002fnk.1_RNA	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	459	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GAACCGAGCTGACATTTTGGA	0.602													1	0	9.39024e-22	0.002222	1.19346e-21	44	87										T	89611106	G	T	89611106	3	4	96	1	0	0	0	0	1	0	0	0	15043	1290	45	3	1563	3	SPG7	16	89611106	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	904745	89611106	743647	767	29243										
SPIRE2	84501	broad.mit.edu	37	chr16	89929889	89929889	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaggccgtcccctaggagttCagccaccccgtggagagcct	13	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr16:89929889C>T	uc002foz.1	+	11	1633	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F	SPIRE2_uc010ciw.1_Silent_p.F527F|SPIRE2_uc002fpa.1_Silent_p.F479F|SPIRE2_uc010cix.1_Silent_p.F394F	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	527					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CCTAGGAGTTCAGCCACCCCG	0.597													0	0	0	0.001368	0	12	36										T	89929889	C	T	89929889	2	4	96	1	0	0	0	0	0	0	0	1	15071	825	29	1		1	SPIRE2	16	89929889	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	318783	89929889	424864	768	29244										
TUSC5	286753	broad.mit.edu	37	chr17	1183661	1183661	+	Frame_Shift_Del	DEL	C	C	-													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtctggcccctcaacctcatCcccctcatcatttccatcat							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:1183661delC	uc002fsi.1	+	1	705	c.366delC	c.(364-366)ATCfs	p.I122fs		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	122	Helical; (Potential).				response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCAACCTCATCCCCCTCATCA	0.617																		56	112	---	---								-	1183661	C	-	1183661	7	5	96	1	0	1	0	1	0	0	0	0	16776	845	30	0	368	0	TUSC5	17	1183661	Frame_Shift_Del	DEL	C	TCGA-G2-A2EO-01A-11D-A17V-08		1183661	80011549	769	29245										
SMG6	23293	broad.mit.edu	37	chr17	2202598	2202598	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcaccccaagatgtagggctGacttcatcatcagtgtccaa	8	12	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:2202598G>A	uc002fub.1	-	2	1504	c.1449C>T	c.(1447-1449)GTC>GTT	p.V483V	SMG6_uc002fud.1_Silent_p.V452V	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	483	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						ATGTAGGGCTGACTTCATCAT	0.512													0	0	0	0.00361	0	102	157										A	2202598	G	A	2202598	2	1	96	1	0	0	0	0	0	0	0	1	14797	1277	45	1		1	SMG6	17	2202598	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1018937	2202598	78992612	770	29246										
OR1G1	8390	broad.mit.edu	37	chr17	3030061	3030061	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggccgagtgggttgagggaGaactgaaatcaacacaaaaa	14	6	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:3030061G>C	uc002fvc.1	-	1	785	c.785C>G	c.(784-786)TCT>TGT	p.S262C		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGTTGAGGGAGAACTGAAATC	0.483													0	0	0	0.007413	0	19	35										C	3030061	G	C	3030061	3	2	96	1	0	0	0	0	1	0	0	0	10957	942	33	1	160	1	OR1G1	17	3030061	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	827463	3030061	78165149	771	29247										
CAMKK1	84254	broad.mit.edu	37	chr17	3779565	3779565	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaaatggcctcgggggccatGaatgctggggttcccgccgt	16	11	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:3779565G>A	uc002fwt.2	-	10	1042	c.948C>T	c.(946-948)TTC>TTT	p.F316F	CAMKK1_uc002fwu.2_Silent_p.F316F|CAMKK1_uc002fwv.2_Silent_p.F354F	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	316	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CGGGGGCCATGAATGCTGGGG	0.627													0	0	0	0.001882	0	21	37										A	3779565	G	A	3779565	2	1	96	1	0	0	0	0	0	0	0	1	2606	1281	45	1		1	CAMKK1	17	3779565	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	749504	3779565	77415645	772	29248										
MYBBP1A	10514	broad.mit.edu	37	chr17	4451467	4451467	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcctggcgctgctgcgcagtGaagggtgtcacggtggtcac	17	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:4451467G>A	uc002fyb.3	-	12	1757	c.1695C>T	c.(1693-1695)TTC>TTT	p.F565F	MYBBP1A_uc002fxz.3_Silent_p.F565F	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	565	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						GCTGCGCAGTGAAGGGTGTCA	0.662													0	0	0	0.002299	0	22	34										A	4451467	G	A	4451467	2	1	96	1	0	0	0	0	0	0	0	1	10008	1281	45	1		1	MYBBP1A	17	4451467	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	671902	4451467	76743743	773	29249										
EIF4A1	1973	broad.mit.edu	37	chr17	7480991	7480991	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggactggctcaccgagaaGatgcatgctcgagatttcac	12	10	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:7480991G>T	uc002gho.1	+	16	2198	c.873G>T	c.(871-873)AAG>AAT	p.K291N	EIF4A1_uc002ghr.1_Missense_Mutation_p.K291N|EIF4A1_uc002ghq.1_Missense_Mutation_p.K291N|EIF4A1_uc002ghp.1_Missense_Mutation_p.K291N|SNORA67_uc010cml.1_5'Flank|CD68_uc002ghv.2_5'Flank|CD68_uc002ghu.2_5'Flank	NM_001416	NP_001407	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A	291	Helicase C-terminal.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			ovary(1)	1						TCACCGAGAAGATGCATGCTC	0.547													1	0	2.98393e-07	0.00278	3.61689e-07	23	107										T	7480991	G	T	7480991	3	4	96	1	0	0	0	0	1	0	0	0	5024	933	33	3	903	3	EIF4A1	17	7480991	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3029524	7480991	73714219	774	29250										
TP53	7157	broad.mit.edu	37	chr17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttcctctgtgcgccggtctCtcccaggacaggcacaaaca	9	16	2	0	rs121912660		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.000978	0	12	20										G	7577099	C	G	7577099	3	3	96	1	0	0	0	0	1	0	0	0	16378	913	32	1	447	1	TP53	17	7577099	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	96108	7577099	73618111	775	29251										
CYB5D1	124637	broad.mit.edu	37	chr17	7761959	7761959	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatccgctgaccggctgcctGaggtactgcaccccgcgggg	15	15	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:7761959G>A	uc002gjb.3	+	3	662	c.273G>A	c.(271-273)CTG>CTA	p.L91L	LSMD1_uc002giz.2_5'Flank|LSMD1_uc002gja.2_5'Flank|CYB5D1_uc010cnn.1_Silent_p.L91L	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	91	Cytochrome b5 heme-binding.						heme binding			skin(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				CCGGCTGCCTGAGGTACTGCA	0.627											OREG0024147	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	54	77										A	7761959	G	A	7761959	2	1	96	1	0	0	0	0	0	0	0	1	4124	1277	45	1		1	CYB5D1	17	7761959	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	184860	7761959	73433251	776	29252										
PIK3R5	23533	broad.mit.edu	37	chr17	8794166	8794166	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcgagtgtccgggcgtactCagcttattggctacagcaag	14	10	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:8794166C>G	uc002glt.2	-	7	613	c.546G>C	c.(544-546)CTG>CTC	p.L182L	PIK3R5_uc010vuz.1_Silent_p.L182L|PIK3R5_uc002glu.3_Intron|PIK3R5_uc010coa.1_Silent_p.L182L|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	182					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CGGGCGTACTCAGCTTATTGG	0.647													0	0	0	0.004482	0	9	29										G	8794166	C	G	8794166	2	3	96	1	0	0	0	0	0	0	0	1	11922	813	29	1		1	PIK3R5	17	8794166	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1032207	8794166	72401044	777	29253										
MYH3	4621	broad.mit.edu	37	chr17	10543550	10543550	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatgagcgaatgttgtactgGatgcagaagatggactccct	12	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:10543550G>C	uc002gmq.1	-	21	2522	c.2445C>G	c.(2443-2445)ATC>ATG	p.I815M		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	815					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGTTGTACTGGATGCAGAAGA	0.478													0	0	0	0.006122	0	18	42										C	10543550	G	C	10543550	3	2	96	1	0	0	0	0	1	0	0	0	10036	1164	41	1	3457	1	MYH3	17	10543550	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1749384	10543550	70651660	778	29254										
ZNF624	57547	broad.mit.edu	37	chr17	16525625	16525625	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tattaactgagtttctctttGatgtattctttgatgtacag	7	5	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:16525625G>C	uc010cpi.1	-	6	2658	c.2575C>G	c.(2575-2577)CAA>GAA	p.Q859E		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	859					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GTTTCTCTTTGATGTATTCTT	0.323													0	0	0	0.00278	0	21	69										C	16525625	G	C	16525625	3	2	96	1	0	0	0	0	1	0	0	0	18045	1299	45	1	26	1	ZNF624	17	16525625	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5982075	16525625	64669585	779	29255										
CCDC144A	9720	broad.mit.edu	37	chr17	16612919	16612919	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagaagagttcctggctttGaagaaagaagatgttcaact	11	5	1	6			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:16612919G>C	uc002gqk.1	+	5	1624	c.1548G>C	c.(1546-1548)TTG>TTC	p.L516F	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	516	Potential.										0						TCCTGGCTTTGAAGAAAGAAG	0.353													0	0	0	0.00361	0	61	104										C	16612919	G	C	16612919	3	2	96	1	0	0	0	0	1	0	0	0	2777	1281	45	1	1566	1	CCDC144A	17	16612919	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	87294	16612919	64582291	780	29256										
SREBF1	6720	broad.mit.edu	37	chr17	17716007	17716007	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagtcgtgcagcagccggcGatcgccaagcttctcgagtg	13	13	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:17716007G>C	uc002gru.1	-	19	3567	c.3373C>G	c.(3373-3375)CGC>GGC	p.R1125G	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Missense_Mutation_p.R744G|SREBF1_uc002grq.1_Missense_Mutation_p.R644G|SREBF1_uc002grr.1_Missense_Mutation_p.R871G|SREBF1_uc002grs.1_Missense_Mutation_p.R1101G|SREBF1_uc002grt.1_Missense_Mutation_p.R1155G	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	1125	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						AGCAGCCGGCGATCGCCAAGC	0.706													0	0	0	0.004672	0	3	12										C	17716007	G	C	17716007	3	2	96	1	0	0	0	0	1	0	0	0	15140	1058	37	1	74	1	SREBF1	17	17716007	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1103088	17716007	63479203	781	29257										
ALDH3A1	218	broad.mit.edu	37	chr17	19642974	19642974	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gactgggggtccacgtccgtGaggatggtgggggctgaggc	21	8	0	2	rs151020632		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:19642974G>A	uc010cqu.2	-	7	1293	c.963C>T	c.(961-963)CTC>CTT	p.L321L	ALDH3A1_uc010vzd.1_Silent_p.L321L|ALDH3A1_uc002gwj.2_Silent_p.L321L|ALDH3A1_uc010cqv.2_Silent_p.L320L|ALDH3A1_uc002gwk.2_Silent_p.L438L|ALDH3A1_uc002gwl.1_Silent_p.L248L	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	321					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	CCACGTCCGTGAGGATGGTGG	0.642													0	0	0	0.004007	0	14	47										A	19642974	G	A	19642974	2	1	96	1	0	0	0	0	0	0	0	1	497	1277	45	1		1	ALDH3A1	17	19642974	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1926967	19642974	61552236	782	29258										
TMEM11	8834	broad.mit.edu	37	chr17	21102080	21102080	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcctgctccagctcgtactCaaactggtcttgggcattct	10	13	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:21102080C>G	uc002gyp.2	-	2	579	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	TMEM11_uc002gyq.2_3'UTR	NM_003876	NP_003867	P17152	TMM11_HUMAN	transmembrane protein 11	46					mitochondrion organization	integral to mitochondrial inner membrane|integral to plasma membrane	protein binding				0						AGCTCGTACTCAAACTGGTCT	0.557													0	0	0	0.00245	0	14	45										G	21102080	C	G	21102080	3	3	96	1	0	0	0	0	1	0	0	0	16023	835	29	1	446	1	TMEM11	17	21102080	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1459106	21102080	60093130	783	29259										
DHRS13	147015	broad.mit.edu	37	chr17	27228278	27228278	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatatggttcacccgaagcaGcaggttaaacgcctcacggg	12	11	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:27228278G>A	uc002hde.3	-	4	539	c.412C>T	c.(412-414)CTG>TTG	p.L138L	DHRS13_uc002hdd.3_Silent_p.L88L|DHRS13_uc010wba.1_Silent_p.L57L	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	138						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			ACCCGAAGCAGCAGGTTAAAC	0.602													0	0	0	0.000978	0	11	141										A	27228278	G	A	27228278	2	1	96	1	0	0	0	0	0	0	0	1	4489	962	34	2		2	DHRS13	17	27228278	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6126198	27228278	53966932	784	29260										
TAOK1	57551	broad.mit.edu	37	chr17	27861196	27861196	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgaagatgcagctgcagcagGaactggagctgttgaatgcg	15	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:27861196G>A	uc002hdz.1	+	19	2616	c.2422G>A	c.(2422-2424)GAA>AAA	p.E808K	TAOK1_uc010wbe.1_Missense_Mutation_p.E660K|TAOK1_uc010wbf.1_Missense_Mutation_p.E808K	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	808	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			GCTGCAGCAGGAACTGGAGCT	0.488													0	0	0	0.00361	0	58	43										A	27861196	G	A	27861196	3	1	96	1	0	0	0	0	1	0	0	0	15544	1175	41	1	2492	1	TAOK1	17	27861196	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	632918	27861196	53334014	785	29261										
EFCAB5	374786	broad.mit.edu	37	chr17	28380455	28380455	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagatcaacctaaacttaacGaacagagaacatcaacacca	4	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:28380455G>A	uc002het.2	+	10	1675	c.1483G>A	c.(1483-1485)GAA>AAA	p.E495K	EFCAB5_uc010wbi.1_Missense_Mutation_p.E238K|EFCAB5_uc010wbj.1_Missense_Mutation_p.E439K|EFCAB5_uc010wbk.1_Missense_Mutation_p.E152K|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Missense_Mutation_p.E374K|EFCAB5_uc010csf.2_Missense_Mutation_p.E374K	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	495							calcium ion binding			ovary(1)|skin(1)	2						TAAACTTAACGAACAGAGAAC	0.388													0	0	0	0.002836	0	33	216										A	28380455	G	A	28380455	3	1	96	1	0	0	0	0	1	0	0	0	4938	1059	37	1	1521	1	EFCAB5	17	28380455	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	519259	28380455	52814755	786	29262										
NF1	4763	broad.mit.edu	37	chr17	29552264	29552264	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagggaaaagggaactcctCtatggtcagcttcttctgta	11	8	4	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:29552264C>G	uc002hgg.2	+	17	2330	c.1997C>G	c.(1996-1998)TCT>TGT	p.S666C	NF1_uc002hgh.2_Missense_Mutation_p.S666C|NF1_uc010csn.1_Missense_Mutation_p.S526C|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	666					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGGAACTCCTCTATGGTCAGC	0.373			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.007413	0	16	111										G	29552264	C	G	29552264	3	3	96	1	0	0	0	0	1	0	0	0	10356	913	32	1	2124	1	NF1	17	29552264	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1171809	29552264	51642946	787	29263										
RHOT1	55288	broad.mit.edu	37	chr17	30519316	30519316	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgctgaactcaacttctttCaggtaatggtcctttatttc	6	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:30519316C>G	uc002hgz.2	+	9	876	c.637C>G	c.(637-639)CAG>GAG	p.Q213E	RHOT1_uc002hgw.2_Missense_Mutation_p.Q213E|RHOT1_uc002hgy.2_Missense_Mutation_p.Q213E|RHOT1_uc002hha.2_Missense_Mutation_p.Q86E|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_Missense_Mutation_p.Q86E|RHOT1_uc010wby.1_Missense_Mutation_p.Q213E|RHOT1_uc002hhb.2_Missense_Mutation_p.Q192E|RHOT1_uc002hgv.2_Missense_Mutation_p.Q213E	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	213	EF-hand 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				CAACTTCTTTCAGGTAATGGT	0.303													0	0	0	0.001368	0	13	59										G	30519316	C	G	30519316	3	3	96	1	0	0	0	0	1	0	0	0	13343	827	29	1	671	1	RHOT1	17	30519316	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	967052	30519316	50675894	788	29264										
PEX12	5193	broad.mit.edu	37	chr17	33903113	33903113	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagtcaaggaactgcaagaaGaatacacccacagaaaggcc	9	11	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:33903113G>C	uc002hjp.2	-	3	1384	c.768C>G	c.(766-768)TTC>TTG	p.F256L		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	256	Helical; (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACTGCAAGAAGAATACACCCA	0.468													0	0	0	0.007835	0	43	73										C	33903113	G	C	33903113	3	2	96	1	0	0	0	0	1	0	0	0	11740	933	33	1	315	1	PEX12	17	33903113	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3383797	33903113	47292097	789	29265										
AP2B1	163	broad.mit.edu	37	chr17	34036247	34036247	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gttgctttcctggcaggtggCtgtgaaaaacaatatcgatg	12	7	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:34036247C>T	uc002hjr.2	+	18	2606	c.2417C>T	c.(2416-2418)GCT>GTT	p.A806V	AP2B1_uc002hjq.2_Missense_Mutation_p.A820V|AP2B1_uc010wci.1_Missense_Mutation_p.A782V|AP2B1_uc002hjs.2_Missense_Mutation_p.A749V|AP2B1_uc002hjt.2_Missense_Mutation_p.A820V|AP2B1_uc010ctv.2_Missense_Mutation_p.A820V|AP2B1_uc010wcj.1_Missense_Mutation_p.A557V	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	806					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TGGCAGGTGGCTGTGAAAAAC	0.473													0	0	0	0.000978	0	12	67										T	34036247	C	T	34036247	3	4	96	1	0	0	0	0	1	0	0	0	741	797	28	2	2529	2	AP2B1	17	34036247	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	133134	34036247	47158963	790	29266										
GAS2L2	246176	broad.mit.edu	37	chr17	34073061	34073061	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggacagactctggctccctGaactggaagaacgcaccctt	10	14	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:34073061G>A	uc002hjv.1	-	6	1483	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	485					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGCTCCCTGAACTGGAAGA	0.642													0	0	0	0.00361	0	49	87										A	34073061	G	A	34073061	2	1	96	1	0	0	0	0	0	0	0	1	6247	1281	45	1		1	GAS2L2	17	34073061	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	36814	34073061	47122149	791	29267										
GAS2L2	246176	broad.mit.edu	37	chr17	34076186	34076186	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacttcccctcagacactttGaccatggagaactgcactgg	8	13	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:34076186G>C	uc002hjv.1	-	3	706	c.678C>G	c.(676-678)GTC>GTG	p.V226V		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	226	GAR.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAGACACTTTGACCATGGAGA	0.592													0	0	0	0.000602	0	5	29										C	34076186	G	C	34076186	2	2	96	1	0	0	0	0	0	0	0	1	6247	1277	45	1		1	GAS2L2	17	34076186	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3125	34076186	47119024	792	29268										
ACACA	31	broad.mit.edu	37	chr17	35631157	35631157	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaacatttaagatacgttttGaaaaatcattttcctgccag	6	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:35631157G>C	uc002hnm.2	-	9	1015	c.824C>G	c.(823-825)TCA>TGA	p.S275*	ACACA_uc002hnk.2_Nonsense_Mutation_p.S197*|ACACA_uc002hnl.2_Nonsense_Mutation_p.S217*|ACACA_uc002hnn.2_Nonsense_Mutation_p.S275*|ACACA_uc002hno.2_Nonsense_Mutation_p.S312*|ACACA_uc010cuz.2_Nonsense_Mutation_p.S275*|ACACA_uc002hnq.2_Nonsense_Mutation_p.S197*	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	275	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GATACGTTTTGAAAAATCATT	0.413													0	0	0	0.008871	0	17	61										C	35631157	G	C	35631157	4	2	96	1	0	0	0	0	0	1	0	0	106	1294	45	1	6408	1	ACACA	17	35631157	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1554971	35631157	45564053	793	29269										
SRCIN1	80725	broad.mit.edu	37	chr17	36715882	36715882	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggcgctgttctgcaggcctCgcaggtgaagctgcatctgc	14	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:36715882C>T	uc002hqd.2	-	10	2189	c.1964G>A	c.(1963-1965)CGA>CAA	p.R655Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.R527Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.R509Q|SRCIN1_uc002hqg.2_5'Flank	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	527	Potential.|Interaction with SNAP25 (By similarity).				exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						CTGCAGGCCTCGCAGGTGAAG	0.736													0	0	0	0.004482	0	8	25										T	36715882	C	T	36715882	3	4	96	1	0	0	0	0	1	0	0	0	15135	884	31	1	1627	1	SRCIN1	17	36715882	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1084725	36715882	44479328	794	29270										
TOP2A	7153	broad.mit.edu	37	chr17	38551779	38551779	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcttcttgagggcttccttCagtattttcattctaaaaga	6	8	5	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:38551779C>T	uc002huq.2	-	29	3859	c.3733G>A	c.(3733-3735)GAA>AAA	p.E1245K		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1245					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GGGCTTCCTTCAGTATTTTCA	0.289													0	0	0	0.004482	0	7	45										T	38551779	C	T	38551779	3	4	96	1	0	0	0	0	1	0	0	0	16362	835	29	1	890	1	TOP2A	17	38551779	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1835897	38551779	42643431	795	29271										
CCR7	1236	broad.mit.edu	37	chr17	38711414	38711414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgacaaggtaacagaagctCatggccagcagggggaccag	14	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:38711414C>T	uc002huw.2	-	3	780	c.717G>A	c.(715-717)ATG>ATA	p.M239I		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	239	Helical; Name=5; (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				AACAGAAGCTCATGGCCAGCA	0.557													0	0	0	0.008291	0	11	47										T	38711414	C	T	38711414	3	4	96	1	0	0	0	0	1	0	0	0	2946	826	29	1	423	1	CCR7	17	38711414	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	159635	38711414	42483796	796	29272										
KRT10	3858	broad.mit.edu	37	chr17	38978738	38978738	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgctgctagaaattcttaGggatgacactcctcctcctc	7	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:38978738G>A	uc002hvi.2	-	1	126	c.100C>T	c.(100-102)CTA>TTA	p.L34L	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	34	Head.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				GAAATTCTTAGGGATGACAct	0.423													0	0	0	0.00499	0	18	48										A	38978738	G	A	38978738	2	1	96	1	0	0	0	0	0	0	0	1	8448	991	35	2		2	KRT10	17	38978738	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	267324	38978738	42216472	797	29273										
KRT12	3859	broad.mit.edu	37	chr17	39022938	39022938	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctgtgaagcatctgcagtCccagttcctcgtgtttcata	8	12	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39022938C>T	uc002hvk.2	-	1	525	c.501G>A	c.(499-501)GGG>GGA	p.G167G		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	167	Rod.|Linker 1.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CATCTGCAGTCCCAGTTCCTC	0.413													0	0	0	0.003214	0	46	146										T	39022938	C	T	39022938	2	4	96	1	0	0	0	0	0	0	0	1	8449	842	30	1		1	KRT12	17	39022938	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	44200	39022938	42172272	798	29274										
KRT37	8688	broad.mit.edu	37	chr17	39580734	39580734	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttgctccaggagccatggtGcaacccagagggcatgagga	14	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39580734G>A	uc002hwp.1	-	1	89	c.42C>T	c.(40-42)TGC>TGT	p.C14C	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	14	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GAGCCATGGTGCAACCCAGAG	0.577													0	0	0	0.002445	0	30	101										A	39580734	G	A	39580734	2	1	96	1	0	0	0	0	0	0	0	1	8474	1311	46	2		2	KRT37	17	39580734	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	557796	39580734	41614476	799	29275										
KRT37	8688	broad.mit.edu	37	chr17	39580750	39580750	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtgcaacccagagggcatGaggaggtgctgtagaaggag	18	6	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:39580750G>A	uc002hwp.1	-	1	73	c.26C>T	c.(25-27)TCA>TTA	p.S9L	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	9	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CAGAGGGCATGAGGAGGTGCT	0.577													0	0	0	0.002096	0	28	94										A	39580750	G	A	39580750	3	1	96	1	0	0	0	0	1	0	0	0	8474	1294	45	1	1351	1	KRT37	17	39580750	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	16	39580750	41614460	800	29276										
ACLY	47	broad.mit.edu	37	chr17	40025364	40025364	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgagaccatctacattcagGataagatttggcttctggga	10	7	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:40025364G>C	uc002hyg.2	-	27	3229	c.3066C>G	c.(3064-3066)ATC>ATG	p.I1022M	ACLY_uc002hyh.2_Missense_Mutation_p.I1012M|ACLY_uc002hyi.2_Missense_Mutation_p.I1076M|ACLY_uc010wfx.1_Missense_Mutation_p.I1066M|ACLY_uc010wfy.1_Missense_Mutation_p.I751M	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	1022					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CTACATTCAGGATAAGATTTG	0.363													0	0	0	0.00245	0	13	294										C	40025364	G	C	40025364	3	2	96	1	0	0	0	0	1	0	0	0	143	1164	41	1	251	1	ACLY	17	40025364	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	444614	40025364	41169846	801	29277										
TTC25	83538	broad.mit.edu	37	chr17	40095357	40095357	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agctgcatagggaatgcccaGattgagctggggcagatgga	16	7	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:40095357G>C	uc002hyj.3	+	7	1079	c.990G>C	c.(988-990)CAG>CAC	p.Q330H	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Intron	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	330	TPR 5.					cytoplasm	protein binding	p.Q330Q(1)		ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				GGAATGCCCAGATTGAGCTGG	0.537													0	0	0	0.004482	0	9	35										C	40095357	G	C	40095357	3	2	96	1	0	0	0	0	1	0	0	0	16690	933	33	1	1016	1	TTC25	17	40095357	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	69993	40095357	41099853	802	29278										
PLEKHH3	79990	broad.mit.edu	37	chr17	40820225	40820225	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctggctgggaggggaggtgtCtggcaggtcttggcatggag	21	6	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:40820225C>A	uc002iau.2	-	13	2769	c.2302G>T	c.(2302-2304)GAC>TAC	p.D768Y	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Missense_Mutation_p.D129Y|PLEKHH3_uc002iaw.2_3'UTR	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	768					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GGGGAGGTGTCTGGCAGGTCT	0.647													1	0	1.10923e-09	0.00278	1.36521e-09	22	41										A	40820225	C	A	40820225	3	1	96	1	0	0	0	0	1	0	0	0	12078	913	32	3	83	3	PLEKHH3	17	40820225	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	724868	40820225	40374985	803	29279										
MPP3	4356	broad.mit.edu	37	chr17	41879119	41879119	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtgtccttgctcagcttctCtaagaccactttgagctggc	9	12	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:41879119C>G	uc002iei.3	-	20	1874	c.1708G>C	c.(1708-1710)GAG>CAG	p.E570Q	MPP3_uc002ieh.2_Missense_Mutation_p.E595Q|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	570	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CTCAGCTTCTCTAAGACCACT	0.423													0	0	0	0.00361	0	46	99										G	41879119	C	G	41879119	3	3	96	1	0	0	0	0	1	0	0	0	9735	922	32	1	53	1	MPP3	17	41879119	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1058894	41879119	39316091	804	29280										
GFAP	2670	broad.mit.edu	37	chr17	42987985	42987985	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggccctgctgtactgacctCgaatctgcaggttggagaag	13	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:42987985C>G	uc002ihq.2	-	7	1229	c.1169G>C	c.(1168-1170)CGA>CCA	p.R390P	GFAP_uc002ihr.2_Missense_Mutation_p.R390P	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	390	Tail.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				GTACTGACCTCGAATCTGCAG	0.622													0	0	0	0.000248	0	4	3										G	42987985	C	G	42987985	3	3	96	1	0	0	0	0	1	0	0	0	6337	884	31	1	270	1	GFAP	17	42987985	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1108866	42987985	38207225	805	29281										
C1QL1	10882	broad.mit.edu	37	chr17	43037561	43037561	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggagacgtggggagctcagtCggagtagatgatgaagccag	18	6	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:43037561C>A	uc002ihv.2	-	2	1000	c.772G>T	c.(772-774)GAC>TAC	p.D258Y		NM_006688	NP_006679	O75973	C1QRF_HUMAN	complement component 1, q subcomponent-like 1	258	C1q.				locomotory behavior	collagen					0		Prostate(33;0.155)				GGAGCTCAGTCGGAGTAGATG	0.657													1	0	9.39024e-22	0.002222	1.19346e-21	44	122										A	43037561	C	A	43037561	3	1	96	1	0	0	0	0	1	0	0	0	1958	884	31	3	8	3	C1QL1	17	43037561	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	49576	43037561	38157649	806	29282										
MAPT	4137	broad.mit.edu	37	chr17	44061213	44061213	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttgggagaggacacaaaagAggctgaccttccagagccct	12	10	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:44061213A>T	uc002ijr.3	+	6	1363	c.1043A>T	c.(1042-1044)GAG>GTG	p.E348V	MAPT_uc010dau.2_Missense_Mutation_p.E348V|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	348					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GACACAAAAGAGGCTGACCTT	0.637													0	0	0	0.005443	0	27	98										T	44061213	A	T	44061213	3	4	96	1	0	0	0	0	1	0	0	0	9297	304	11	5	1061	5	MAPT	17	44061213	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	1023652	44061213	37133997	807	29283										
STH	246744	broad.mit.edu	37	chr17	44076776	44076776	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggatgattcaggttgccaGagacagaaccctcagcttag	12	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:44076776G>C	uc002ijy.2	+	1	161	c.131G>C	c.(130-132)AGA>ACA	p.R44T	MAPT_uc010dau.2_Intron|MAPT_uc002ijr.3_Intron|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_001007532	NP_001007533	Q8IWL8	STH_HUMAN	saitohin	44						cytoplasm|nucleus					0						CAGGTTGCCAGAGACAGAACC	0.388													0	0	0	0.001368	0	12	48										C	44076776	G	C	44076776	3	2	96	1	0	0	0	0	1	0	0	0	15280	942	33	1	133	1	STH	17	44076776	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	15563	44076776	37118434	808	29284										
KIAA1267	284058	broad.mit.edu	37	chr17	44144094	44144094	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggtctgccaagacaggctGaagactatacaaggggaagg	15	7	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:44144094G>A	uc002ikb.2	-	5	1742	c.1657C>T	c.(1657-1659)CAG>TAG	p.Q553*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.Q553*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.Q553*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.Q553*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	553						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				AAGACAGGCTGAAGACTATAC	0.338													0	0	0	0.001368	0	12	35										A	44144094	G	A	44144094	4	1	96	1	0	0	0	0	0	1	0	0	8219	1299	45	1	1700	1	KIAA1267	17	44144094	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	67318	44144094	37051116	809	29285										
PNPO	55163	broad.mit.edu	37	chr17	46023278	46023278	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgaggaggaggctgagtgcTacttccactcccgccccaag	12	14	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:46023278T>C	uc002imo.2	+	5	622	c.469T>C	c.(469-471)TAC>CAC	p.Y157H	PNPO_uc010wkz.1_Missense_Mutation_p.Y139H|PNPO_uc010wla.1_Missense_Mutation_p.Y62H|PNPO_uc010wlb.1_Intron	NM_018129	NP_060599	Q9NVS9	PNPO_HUMAN	pyridoxine 5'-phosphate oxidase	157		Substrate.			pyridoxine biosynthetic process	cytosol	FMN binding|pyridoxamine-phosphate oxidase activity				0					Pyridoxal Phosphate(DB00114)	GGCTGAGTGCTACTTCCACTC	0.597													0	0	0	0.006122	0	19	42										C	46023278	T	C	46023278	3	2	96	1	0	0	0	0	1	0	0	0	12172	1522	53	5	487	5	PNPO	17	46023278	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	1879184	46023278	35171932	810	29286										
CACNA1G	8913	broad.mit.edu	37	chr17	48669297	48669297	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attcctgtcttctgcccgcaGatcctgacccaggaggactg	10	14	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:48669297G>T	uc002irk.1	+	13	3127	c.2755_splice	c.e13-1	p.I919_splice	CACNA1G_uc002iri.1_Splice_Site_p.I919_splice|CACNA1G_uc002irj.1_Splice_Site_p.I919_splice|CACNA1G_uc002irl.1_Splice_Site_p.I919_splice|CACNA1G_uc002irm.1_Splice_Site_p.I919_splice|CACNA1G_uc002irn.1_Splice_Site_p.I919_splice|CACNA1G_uc002iro.1_Splice_Site_p.I919_splice|CACNA1G_uc002irp.1_Splice_Site_p.I919_splice|CACNA1G_uc002irq.1_Splice_Site_p.I919_splice|CACNA1G_uc002irr.1_Splice_Site_p.I919_splice|CACNA1G_uc002irs.1_Splice_Site_p.I919_splice|CACNA1G_uc002irt.1_Splice_Site_p.I919_splice|CACNA1G_uc002irv.1_Splice_Site_p.I919_splice|CACNA1G_uc002irw.1_Splice_Site_p.I919_splice|CACNA1G_uc002iru.1_Splice_Site_p.I919_splice|CACNA1G_uc002irx.1_Splice_Site_p.I832_splice|CACNA1G_uc002iry.1_Splice_Site_p.I832_splice|CACNA1G_uc002irz.1_Splice_Site_p.I832_splice|CACNA1G_uc002isa.1_Splice_Site_p.I832_splice|CACNA1G_uc002isb.1_Splice_Site_p.I832_splice|CACNA1G_uc002isc.1_Splice_Site_p.I832_splice|CACNA1G_uc002isd.1_Splice_Site_p.I832_splice|CACNA1G_uc002ise.1_Splice_Site_p.I832_splice|CACNA1G_uc002isf.1_Splice_Site_p.I832_splice|CACNA1G_uc002isg.1_Splice_Site_p.I832_splice|CACNA1G_uc002ish.1_Splice_Site_p.I832_splice|CACNA1G_uc002isi.1_Splice_Site_p.I832_splice	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G						axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TCTGCCCGCAGATCCTGACCC	0.582													1	0	6.31663e-08	0.003163	7.68238e-08	15	12										T	48669297	G	T	48669297	5	4	96	1	0	0	0	0	0	0	1	0	2544	956	33	3	2804	3	CACNA1G	17	48669297	Splice_Site	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2646019	48669297	32525913	811	29287										
CACNA1G	8913	broad.mit.edu	37	chr17	48678510	48678510	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catcaccatcgccatggagcGccccaaaattgacccccaca	6	18	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:48678510G>A	uc002irk.1	+	19	4262	c.3890G>A	c.(3889-3891)CGC>CAC	p.R1297H	CACNA1G_uc002iri.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irj.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irl.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irm.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irn.1_Missense_Mutation_p.R1274H|CACNA1G_uc002iro.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irp.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irq.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irr.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irs.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irt.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irv.1_Missense_Mutation_p.R1297H|CACNA1G_uc002irw.1_Missense_Mutation_p.R1274H|CACNA1G_uc002iru.1_Missense_Mutation_p.R1274H|CACNA1G_uc002irx.1_Missense_Mutation_p.R1210H|CACNA1G_uc002iry.1_Missense_Mutation_p.R1210H|CACNA1G_uc002irz.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isa.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isb.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isc.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isd.1_Missense_Mutation_p.R1210H|CACNA1G_uc002ise.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isf.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isg.1_Missense_Mutation_p.R1210H|CACNA1G_uc002ish.1_Missense_Mutation_p.R1210H|CACNA1G_uc002isi.1_Missense_Mutation_p.R1187H|CACNA1G_uc002isj.2_Missense_Mutation_p.R21H	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1297	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCCATGGAGCGCCCCAAAATT	0.592													0	0	0	0.007291	0	31	35										A	48678510	G	A	48678510	3	1	96	1	0	0	0	0	1	0	0	0	2544	1087	38	2	3964	2	CACNA1G	17	48678510	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9213	48678510	32516700	812	29288										
C17orf67	339210	broad.mit.edu	37	chr17	54893199	54893199	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggttcctctgcctcttgctGagtgaatcctcccagactga	9	13	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:54893199G>A	uc010dci.2	-	1	52	c.45C>T	c.(43-45)CTC>CTT	p.L15L	C17orf67_uc002iuq.2_RNA	NM_001085430	NP_001078899	Q0P5P2	CQ067_HUMAN	hypothetical protein LOC339210 precursor	15						extracellular region					0	Breast(9;2.49e-06)					GCCTCTTGCTGAGTGAATCCT	0.517													0	0	0	0.006214	0	10	81										A	54893199	G	A	54893199	2	1	96	1	0	0	0	0	0	0	0	1	1875	1277	45	1		1	C17orf67	17	54893199	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6214689	54893199	26302011	813	29289										
CLTC	1213	broad.mit.edu	37	chr17	57743597	57743597	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatgaaccttatgcatgcgcCtcaagtatgtgttttaatgc	9	8	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:57743597C>G	uc002ixq.1	+	11	2221	c.1778C>G	c.(1777-1779)CCT>CGT	p.P593R	CLTC_uc002ixp.2_Missense_Mutation_p.P593R|CLTC_uc002ixr.1_Missense_Mutation_p.P597R	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	593	Heavy chain arm.|Distal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ATGCATGCGCCTCAAGTATGT	0.433			T	ALK|TFE3	ALCL|renal 								0	0	0	0.000978	0	10	100										G	57743597	C	G	57743597	3	3	96	1	0	0	0	0	1	0	0	0	3566	681	24	4	1820	4	CLTC	17	57743597	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2850398	57743597	23451613	814	29290										
CLTC	1213	broad.mit.edu	37	chr17	57754433	57754433	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ataacaacccggagagatttCttcgtgaaaatccctactat	6	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:57754433C>G	uc002ixq.1	+	17	3123	c.2680C>G	c.(2680-2682)CTT>GTT	p.L894V	CLTC_uc002ixp.2_Missense_Mutation_p.L894V|CLTC_uc002ixr.1_Missense_Mutation_p.L898V	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	894	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GGAGAGATTTCTTCGTGAAAA	0.458			T	ALK|TFE3	ALCL|renal 								0	0	0	0.002222	0	43	58										G	57754433	C	G	57754433	3	3	96	1	0	0	0	0	1	0	0	0	3566	913	32	1	2746	1	CLTC	17	57754433	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10836	57754433	23440777	815	29291										
MED13	9969	broad.mit.edu	37	chr17	60108955	60108955	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggagtaggaatgtctgactGagggactagaacaaagcatg	14	5	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:60108955G>A	uc002izo.2	-	6	936	c.859C>T	c.(859-861)CAG>TAG	p.Q287*	MED13_uc002izp.2_5'Flank	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	287					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						ATGTCTGACTGAGGGACTAGA	0.468													0	0	0	0.000978	0	11	51										A	60108955	G	A	60108955	4	1	96	1	0	0	0	0	0	1	0	0	9430	1299	45	1	5765	1	MED13	17	60108955	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2354522	60108955	21086255	816	29292										
MRC2	9902	broad.mit.edu	37	chr17	60743976	60743976	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atccacgagcagacctacatCaacggtgagccggggcctga	12	13	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:60743976C>G	uc002jad.2	+	4	1257	c.855C>G	c.(853-855)ATC>ATG	p.I285M	MRC2_uc002jac.2_Missense_Mutation_p.I285M	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	285	Extracellular (Potential).|C-type lectin 1.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						AGACCTACATCAACGGTGAGC	0.677													0	0	0	0.000248	0	4	18										G	60743976	C	G	60743976	3	3	96	1	0	0	0	0	1	0	0	0	9758	816	29	1	869	1	MRC2	17	60743976	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	635021	60743976	20451234	817	29293										
MRC2	9902	broad.mit.edu	37	chr17	60767311	60767311	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgaactacgtgggctggcaGgacggggagccgcagcagcc	17	12	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:60767311G>A	uc002jad.2	+	25	4032	c.3630G>A	c.(3628-3630)CAG>CAA	p.Q1210Q	MRC2_uc002jae.2_Silent_p.Q281Q|MRC2_uc002jaf.2_Silent_p.Q76Q	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1210	Extracellular (Potential).|C-type lectin 7.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGGGCTGGCAGGACGGGGAGC	0.677													0	0	0	0.000602	0	5	38										A	60767311	G	A	60767311	2	1	96	1	0	0	0	0	0	0	0	1	9758	991	35	2		2	MRC2	17	60767311	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	23335	60767311	20427899	818	29294										
GNA13	10672	broad.mit.edu	37	chr17	63052692	63052692	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acacggacagcacggaccgcGacggcaggaagtccgccatc	13	15	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:63052692G>A	uc002jfc.2	-	1	229	c.20C>T	c.(19-21)TCG>TTG	p.S7L	GNA13_uc010wqh.1_5'Flank	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	7					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						CACGGACCGCGACGGCAGGAA	0.587													0	0	0	0.00361	0	94	114										A	63052692	G	A	63052692	3	1	96	1	0	0	0	0	1	0	0	0	6501	1059	37	1	1129	1	GNA13	17	63052692	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2285381	63052692	18142518	819	29295										
FAM20A	54757	broad.mit.edu	37	chr17	66550954	66550954	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcccccagcaaggctttctCatcttgactgtaatctgcaa	7	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66550954C>T	uc002jho.2	-	3	892	c.604G>A	c.(604-606)GAG>AAG	p.E202K	FAM20A_uc010wqp.1_Missense_Mutation_p.E64K|FAM20A_uc002jhn.2_5'UTR	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	202						extracellular region					0	Breast(10;1.64e-13)					AAGGCTTTCTCATCTTGACTG	0.542													0	0	0	0.00874	0	39	39										T	66550954	C	T	66550954	3	4	96	1	0	0	0	0	1	0	0	0	5537	835	29	1	1057	1	FAM20A	17	66550954	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3498262	66550954	14644256	820	29296										
ABCA8	10351	broad.mit.edu	37	chr17	66899010	66899010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agggcaaaatccagccattaGaattaatagcctacacaaaa	6	9	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66899010G>C	uc002jhp.2	-	19	2667	c.2488C>G	c.(2488-2490)CTA>GTA	p.L830V	ABCA8_uc002jhq.2_Missense_Mutation_p.L870V|ABCA8_uc010wqq.1_Missense_Mutation_p.L870V|ABCA8_uc010wqr.1_Missense_Mutation_p.L809V|ABCA8_uc002jhr.2_Missense_Mutation_p.L870V	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	830	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CCAGCCATTAGAATTAATAGC	0.348													0	0	0	0.003954	0	20	106										C	66899010	G	C	66899010	3	2	96	1	0	0	0	0	1	0	0	0	38	933	33	1	2337	1	ABCA8	17	66899010	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	348056	66899010	14296200	821	29297										
ABCA8	10351	broad.mit.edu	37	chr17	66925208	66925208	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acctgggccattccaagcatGaaggcaaagggactaagcaa	11	10	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66925208G>A	uc002jhp.2	-	8	1286	c.1107C>T	c.(1105-1107)TTC>TTT	p.F369F	ABCA8_uc002jhq.2_Silent_p.F369F|ABCA8_uc010wqq.1_Silent_p.F369F|ABCA8_uc010wqr.1_Silent_p.F308F|ABCA8_uc002jhr.2_Silent_p.F369F	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	369	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TTCCAAGCATGAAGGCAAAGG	0.458													0	0	0	0.00632	0	24	76										A	66925208	G	A	66925208	2	1	96	1	0	0	0	0	0	0	0	1	38	1281	45	1		1	ABCA8	17	66925208	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	26198	66925208	14270002	822	29298										
ABCA9	10350	broad.mit.edu	37	chr17	66980209	66980209	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcactcacctcagccttcctGacaccatgatggccactcgg	8	17	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:66980209G>A	uc002jhu.2	-	35	4630	c.4487C>T	c.(4486-4488)TCA>TTA	p.S1496L	ABCA9_uc010dez.2_Missense_Mutation_p.S1458L	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1496	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CAGCCTTCCTGACACCATGAT	0.597													0	0	0	0.004656	0	24	110										A	66980209	G	A	66980209	3	1	96	1	0	0	0	0	1	0	0	0	39	1294	45	1	407	1	ABCA9	17	66980209	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	55001	66980209	14215001	823	29299										
KCTD2	23510	broad.mit.edu	37	chr17	73055613	73055613	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggtcattgcagggccccgtGaagcacgtgtacagagtcct	13	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:73055613G>A	uc002jmp.2	+	4	616	c.549G>A	c.(547-549)GTG>GTA	p.V183V	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	183						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					AGGGCCCCGTGAAGCACGTGT	0.527													0	0	0	0.003163	0	16	38										A	73055613	G	A	73055613	2	1	96	1	0	0	0	0	0	0	0	1	8107	1277	45	1		1	KCTD2	17	73055613	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6075404	73055613	8139597	824	29300										
SRP68	6730	broad.mit.edu	37	chr17	74056437	74056437	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgcccccagacctcaatctCatctgcatgagttcattgat	7	13	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74056437C>T	uc002jqk.1	-	7	824	c.789G>A	c.(787-789)ATG>ATA	p.M263I	SRP68_uc010wsu.1_Missense_Mutation_p.M162I|SRP68_uc002jql.1_Missense_Mutation_p.M225I	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	263					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						ACCTCAATCTCATCTGCATGA	0.428													0	0	0	0.003954	0	19	96										T	74056437	C	T	74056437	3	4	96	1	0	0	0	0	1	0	0	0	15155	826	29	1	1134	1	SRP68	17	74056437	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1000824	74056437	7138773	825	29301										
SRP68	6730	broad.mit.edu	37	chr17	74068563	74068563	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccgcctgggacctgcttctCagcagccatcttgcccctgc	10	18	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74068563C>T	uc002jqk.1	-	1	45	c.10G>A	c.(10-12)GAG>AAG	p.E4K	SRP68_uc010wsu.1_5'UTR|SRP68_uc002jql.1_Missense_Mutation_p.E4K|GALR2_uc002jqm.1_5'Flank	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	4					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						ACCTGCTTCTCAGCAGCCATC	0.463													0	0	0	0.00278	0	23	80										T	74068563	C	T	74068563	3	4	96	1	0	0	0	0	1	0	0	0	15155	835	29	1	1937	1	SRP68	17	74068563	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	12126	74068563	7126647	826	29302										
QRICH2	84074	broad.mit.edu	37	chr17	74283954	74283955	+	Frame_Shift_Del	DEL	CC	CC	-													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcttgattcccttccccttCcaggatcctctgcagccttt							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74283954_74283955delCC	uc002jrd.1	-	6	3504_3505	c.3324_3325delGG	c.(3322-3327)CTGGAAfs	p.L1108fs	QRICH2_uc010wsz.1_Frame_Shift_Del_p.L1034fs|QRICH2_uc010dgw.1_5'UTR	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1108_1109	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCTTCCCCTTCCAGGATCCTCT	0.559																		34	96	---	---								-	74283955	CC	-	74283954	7	5	96	1	0	1	0	1	0	0	0	0	12880	864	30	0	1722	0	QRICH2	17	74283954	Frame_Shift_Del	DEL	CC	TCGA-G2-A2EO-01A-11D-A17V-08	215391	74283954	6911256	827	29303										
UBE2O	63893	broad.mit.edu	37	chr17	74387651	74387651	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcaggcctcggtcactgtcGaagccggcttcgttgtagta	13	11	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74387651G>A	uc002jrm.3	-	18	3317	c.3252C>T	c.(3250-3252)TTC>TTT	p.F1084F	UBE2O_uc002jrl.3_Silent_p.F688F	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	1084							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						GGTCACTGTCGAAGCCGGCTT	0.577													0	0	0	0.00361	0	45	121										A	74387651	G	A	74387651	2	1	96	1	0	0	0	0	0	0	0	1	16865	1049	37	1		1	UBE2O	17	74387651	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	103697	74387651	6807559	828	29304										
SFRS2	6427	broad.mit.edu	37	chr17	74732523	74732523	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aacgactccgactccgggatCggctgcggcgacgccgccta	13	16	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:74732523C>A	uc002jsv.2	-	2	556	c.386G>T	c.(385-387)CGA>CTA	p.R129L	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R129L|SFRS2_uc010wtg.1_Missense_Mutation_p.R117L|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	129	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						ACTCCGGGATCGGCTGCGGCG	0.552													1	0	1.49906e-05	0.00245	1.80187e-05	13	66										A	74732523	C	A	74732523	3	1	96	1	0	0	0	0	1	0	0	0	14175	884	31	3	283	3	SFRS2	17	74732523	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	344872	74732523	6462687	829	29305										
DNAH17	8632	broad.mit.edu	37	chr17	76451810	76451810	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagtagcccacgtaggacacGaaggcagagatgagcaggac	14	9	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:76451810G>A	uc010dhp.1	-	8	1308	c.1086C>T	c.(1084-1086)TTC>TTT	p.F362F	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CGTAGGACACGAAGGCAGAGA	0.522													0	0	0	0.004482	0	9	21										A	76451810	G	A	76451810	2	1	96	1	0	0	0	0	0	0	0	1	4601	1049	37	1		1	DNAH17	17	76451810	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1719287	76451810	4743400	830	29306										
EIF4A3	9775	broad.mit.edu	37	chr17	78115614	78115614	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cactggaggactgagatactGaaggtggctgtttttcctgt	13	7	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:78115614G>A	uc010wuc.1	-	4	349	c.276C>T	c.(274-276)TTC>TTT	p.F92F	EIF4A3_uc002jxs.2_Silent_p.F92F	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	92	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			CTGAGATACTGAAGGTGGCTG	0.438													0	0	0	0.006122	0	17	42										A	78115614	G	A	78115614	2	1	96	1	0	0	0	0	0	0	0	1	5026	1281	45	1		1	EIF4A3	17	78115614	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1663804	78115614	3079596	831	29307										
EIF4A3	9775	broad.mit.edu	37	chr17	78115643	78115643	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtttttcctgtgccggactGagacctattcaaggaaacaa	9	9	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:78115643G>A	uc010wuc.1	-	4	320	c.247C>T	c.(247-249)CAG>TAG	p.Q83*	EIF4A3_uc002jxs.2_Nonsense_Mutation_p.Q83*	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	83	Helicase ATP-binding.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			GTGCCGGACTGAGACCTATTC	0.478													0	0	0	0.001368	0	12	42										A	78115643	G	A	78115643	4	1	96	1	0	0	0	0	0	1	0	0	5026	1299	45	1	1028	1	EIF4A3	17	78115643	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	29	78115643	3079567	832	29308										
RNF213	57674	broad.mit.edu	37	chr17	78359383	78359383	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggatcacagtctttctgtCcacatggaacaaactgagga	9	10	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:78359383C>G	uc002jyh.1	+	36	8943	c.8720C>G	c.(8719-8721)TCC>TGC	p.S2907C	uc002jyi.1_Intron|RNF213_uc010dhx.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	1200										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTCTTTCTGTCCACATGGAAC	0.498													0	0	0	0.001368	0	10	44										G	78359383	C	G	78359383	3	3	96	1	0	0	0	0	1	0	0	0	13477	855	30	1	15058	1	RNF213	17	78359383	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	243740	78359383	2835827	833	29309										
SLC38A10	124565	broad.mit.edu	37	chr17	79263557	79263557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caagaacatgcacgactggtGcgtcatccatgagcagaaga	11	10	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr17:79263557G>A	uc002jzz.1	-	2	526	c.151C>T	c.(151-153)CAC>TAC	p.H51Y	SLC38A10_uc002kab.2_Missense_Mutation_p.H51Y	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	51	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CACGACTGGTGCGTCATCCAT	0.632													0	0	0	0.004007	0	15	35										A	79263557	G	A	79263557	3	1	96	1	0	0	0	0	1	0	0	0	14602	1319	46	2	3546	2	SLC38A10	17	79263557	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	904174	79263557	1931653	834	29310										
EPB41L3	23136	broad.mit.edu	37	chr18	5398076	5398076	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatgaattctgttggttttcGcgcagactctaataaactga	8	7	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:5398076G>A	uc002kmt.1	-	17	2502	c.2416C>T	c.(2416-2418)CGA>TGA	p.R806*	EPB41L3_uc010wzh.1_Nonsense_Mutation_p.R637*|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Nonsense_Mutation_p.R111*|EPB41L3_uc010wzf.1_Nonsense_Mutation_p.R103*|EPB41L3_uc010wzg.1_Nonsense_Mutation_p.R78*|EPB41L3_uc010dkr.2_Nonsense_Mutation_p.R198*	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	806	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GTTGGTTTTCGCGCAGACTCT	0.453													0	0	0	0.00361	0	45	306										A	5398076	G	A	5398076	4	1	96	1	0	0	0	0	0	1	0	0	5154	1095	38	2	871	2	EPB41L3	18	5398076	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		5398076	72679172	835	29311										
ANKRD12	23253	broad.mit.edu	37	chr18	9255144	9255144	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caaatgccaaaataaaggatGaagatcatagtccaacattt	6	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:9255144G>A	uc002knv.2	+	9	2136	c.1879G>A	c.(1879-1881)GAA>AAA	p.E627K	ANKRD12_uc002knw.2_Missense_Mutation_p.E604K|ANKRD12_uc002knx.2_Missense_Mutation_p.E604K|ANKRD12_uc010dkx.1_Missense_Mutation_p.E334K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	627						nucleus				ovary(2)|central_nervous_system(1)	3						AATAAAGGATGAAGATCATAG	0.184													0	0	0	0.00278	0	25	82										A	9255144	G	A	9255144	3	1	96	1	0	0	0	0	1	0	0	0	640	1291	45	1	1909	1	ANKRD12	18	9255144	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3857068	9255144	68822104	836	29312										
PSMG2	56984	broad.mit.edu	37	chr18	12706694	12706694	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcgaccacagaaggaaattCaacagaacttagcataaatg	8	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:12706694C>G	uc002krk.2	+	2	246	c.203C>G	c.(202-204)TCA>TGA	p.S68*	PSMG2_uc002krg.2_Nonsense_Mutation_p.S37*|PSMG2_uc002krj.1_Nonsense_Mutation_p.S68*	NM_020232	NP_064617	Q969U7	PSMG2_HUMAN	proteasome (prosome, macropain) assembly	68					proteasome assembly	nucleus	protein binding				0						GAAGGAAATTCAACAGAACTT	0.323													0	0	0	0.002299	0	22	56										G	12706694	C	G	12706694	4	3	96	1	0	0	0	0	0	1	0	0	12712	838	29	1	209	1	PSMG2	18	12706694	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3451550	12706694	65370554	837	29313										
GATA6	2627	broad.mit.edu	37	chr18	19780746	19780746	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccggccgaagtcacgtcctCcgtgcgaccggattcctggt	13	15	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:19780746C>A	uc002ktt.1	+	7	2013	c.1748C>A	c.(1747-1749)TCC>TAC	p.S583Y	GATA6_uc002ktu.1_Missense_Mutation_p.S583Y	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	583					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			GTCACGTCCTCCGTGCGACCG	0.672													1	0	2.79863e-10	0.004656	3.46223e-10	27	253										A	19780746	C	A	19780746	3	1	96	1	0	0	0	0	1	0	0	0	6258	855	30	3	1770	3	GATA6	18	19780746	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7074052	19780746	58296502	838	29314										
RBBP8	5932	broad.mit.edu	37	chr18	20564853	20564853	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttttttctccccttagaaatGagaaaagtttccaagtcttc	5	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:20564853G>A	uc002ktw.2	+	8	940	c.609G>A	c.(607-609)ATG>ATA	p.M203I	RBBP8_uc002kty.2_Missense_Mutation_p.M203I|RBBP8_uc002ktz.2_Missense_Mutation_p.M203I|RBBP8_uc002kua.2_Missense_Mutation_p.M203I|RBBP8_uc002ktx.1_Missense_Mutation_p.M203I	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	203					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CCTTAGAAATGAGAAAAGTTT	0.274								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.006214	0	9	61										A	20564853	G	A	20564853	3	1	96	1	0	0	0	0	1	0	0	0	13105	1290	45	1	635	1	RBBP8	18	20564853	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	784107	20564853	57512395	839	29315										
LAMA3	3909	broad.mit.edu	37	chr18	21494446	21494446	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctacaacctgggggaccgtGaggctgaactccaagtggac	13	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:21494446G>C	uc002kuq.2	+	57	7488	c.7402G>C	c.(7402-7404)GAG>CAG	p.E2468Q	LAMA3_uc002kur.2_Missense_Mutation_p.E2412Q|LAMA3_uc002kus.3_Missense_Mutation_p.E859Q|LAMA3_uc002kut.3_Missense_Mutation_p.E803Q	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2468	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGGGACCGTGAGGCTGAACT	0.537													0	0	0	0.001168	0	5	72										C	21494446	G	C	21494446	3	2	96	1	0	0	0	0	1	0	0	0	8607	1291	45	1	7803	1	LAMA3	18	21494446	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	929593	21494446	56582802	840	29316										
DSC2	1824	broad.mit.edu	37	chr18	28673588	28673588	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtcacatttttgcaggcatCactggcaaatattaagatct	7	8	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:28673588C>G	uc002kwl.3	-	2	542	c.88G>C	c.(88-90)GAT>CAT	p.D30H	DSC2_uc002kwk.3_Missense_Mutation_p.D30H|DSC2_uc010xbo.1_Missense_Mutation_p.D30H	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	30					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TTGCAGGCATCACTGGCAAAT	0.259													0	0	0	0.00361	0	54	135										G	28673588	C	G	28673588	3	3	96	1	0	0	0	0	1	0	0	0	4766	826	29	1	2717	1	DSC2	18	28673588	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7179142	28673588	49403660	841	29317										
DSG2	1829	broad.mit.edu	37	chr18	29126602	29126602	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagctggagtccctggccctCtgccagattttggtttagag	13	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:29126602C>G	uc002kwu.3	+	15	3441	c.3253C>G	c.(3253-3255)CTG>GTG	p.L1085V	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	1085	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CCCTGGCCCTCTGCCAGATTT	0.478													0	0	0	0.003954	0	24	85										G	29126602	C	G	29126602	3	3	96	1	0	0	0	0	1	0	0	0	4777	912	32	1	3311	1	DSG2	18	29126602	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	453014	29126602	48950646	842	29318										
MCART2	147407	broad.mit.edu	37	chr18	29340499	29340499	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatgtgattgcgacgttgttGaaggctgcacagcagccaca	12	9	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:29340499G>T	uc002kxa.2	-	1	345	c.126C>A	c.(124-126)TTC>TTA	p.F42L		NM_001034172	NP_001029344	Q3SY17	MCAR2_HUMAN	mitochondrial carrier triple repeat 2	42	Solcar 1.|Helical; Name=1; (Potential).				transport	integral to membrane|mitochondrial inner membrane				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.0539)			CGACGTTGTTGAAGGCTGCAC	0.438													1	0	6.03219e-31	0.00361	7.7075e-31	49	126										T	29340499	G	T	29340499	3	4	96	1	0	0	0	0	1	0	0	0	9370	1281	45	3	771	3	MCART2	18	29340499	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	213897	29340499	48736749	843	29319										
FAM59A	64762	broad.mit.edu	37	chr18	29848662	29848662	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggtccacagaatcagttttCactcggttacatggatagca	9	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:29848662C>A	uc002kxl.2	-	6	1859	c.1803G>T	c.(1801-1803)GTG>GTT	p.V601V	FAM59A_uc002kxk.1_Silent_p.V600V	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	601										ovary(1)|skin(1)	2						AATCAGTTTTCACTCGGTTAC	0.458													1	0	1.05317e-09	0.00245	1.29843e-09	15	46										A	29848662	C	A	29848662	2	1	96	1	0	0	0	0	0	0	0	1	5592	813	29	3		3	FAM59A	18	29848662	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	508163	29848662	48228586	844	29320										
CELF4	56853	broad.mit.edu	37	chr18	34839145	34839145	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttcgaggagatgacattaccGaaagggaggaacatctgcat	12	7	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:34839145G>A	uc002lae.2	-	11	1728	c.1332C>T	c.(1330-1332)TTC>TTT	p.F444F	CELF4_uc010dnd.1_Silent_p.F442F|CELF4_uc002lag.2_Intron|CELF4_uc002laf.2_Silent_p.F438F|CELF4_uc002lai.2_Silent_p.F428F	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	444	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGACATTACCGAAAGGGAGGA	0.488													0	0	0	0.005443	0	24	61										A	34839145	G	A	34839145	2	1	96	1	0	0	0	0	0	0	0	1	3218	1072	37	1		1	CELF4	18	34839145	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4990483	34839145	43238103	845	29321										
SLC14A2	8170	broad.mit.edu	37	chr18	43221187	43221187	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccatagccctgtcagtggcCacacccttcgagaccatcta	7	17	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:43221187C>A	uc010dnj.2	+	9	1326	c.1005C>A	c.(1003-1005)GCC>GCA	p.A335A	SLC14A2_uc002lbb.2_Silent_p.A335A|SLC14A2_uc002lbe.2_Silent_p.A335A	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	335						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TGTCAGTGGCCACACCCTTCG	0.577													1	0	6.81908e-15	0.00245	8.55355e-15	14	136										A	43221187	C	A	43221187	2	1	96	1	0	0	0	0	0	0	0	1	14397	581	21	4		4	SLC14A2	18	43221187	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	8382042	43221187	34856061	846	29322										
SLC14A1	6563	broad.mit.edu	37	chr18	43310353	43310353	+	Frame_Shift_Del	DEL	C	C	-													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taggggtgaaaaccaggtttCgccatgtcaagggagaaggt							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:43310353delC	uc010xcn.1	+	4	387	c.68delC	c.(67-69)TCGfs	p.S23fs	SLC14A1_uc010dnk.2_Frame_Shift_Del_p.S79fs|SLC14A1_uc002lbf.3_Frame_Shift_Del_p.S23fs|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Intron|SLC14A1_uc002lbh.3_Intron|SLC14A1_uc002lbi.3_Intron|SLC14A1_uc002lbj.3_Frame_Shift_Del_p.S79fs|SLC14A1_uc002lbk.3_Frame_Shift_Del_p.S23fs	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	23						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						AACCAGGTTTCGCCATGTCAA	0.507																		35	77	---	---								-	43310353	C	-	43310353	7	5	96	1	0	1	0	1	0	0	0	0	14396	893	31	0	242	0	SLC14A1	18	43310353	Frame_Shift_Del	DEL	C	TCGA-G2-A2EO-01A-11D-A17V-08	89166	43310353	34766895	847	29323										
TCEB3B	51224	broad.mit.edu	37	chr18	44559892	44559892	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgattcctccgtaattcgtCtgtctctctaacgagtgcgt	8	11	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:44559892C>G	uc002lcr.1	-	1	2097	c.1744G>C	c.(1744-1746)GAC>CAC	p.D582H	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	582	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CGTAATTCGTCTGTCTCTCTA	0.517													0	0	0	0.004482	0	8	77										G	44559892	C	G	44559892	3	3	96	1	0	0	0	0	1	0	0	0	15679	913	32	1	521	1	TCEB3B	18	44559892	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1249539	44559892	33517356	848	29324										
IER3IP1	51124	broad.mit.edu	37	chr18	44702592	44702592	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgctcctcgtgcagcactgcGatggcgttgacgcagagcag	14	13	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:44702592G>T	uc002lcu.2	-	1	154	c.57C>A	c.(55-57)ATC>ATA	p.I19I		NM_016097	NP_057181	Q9Y5U9	IR3IP_HUMAN	immediate early response 3 interacting protein	19	Helical; (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane					0						GCAGCACTGCGATGGCGTTGA	0.468													1	0	3.59834e-05	0.001168	4.30724e-05	6	16										T	44702592	G	T	44702592	2	4	96	1	0	0	0	0	0	0	0	1	7507	1048	37	3		3	IER3IP1	18	44702592	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	142700	44702592	33374656	849	29325										
SKA1	220134	broad.mit.edu	37	chr18	47918545	47918545	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagaagtttcacgtgttactGaatattttacgacactgccg	8	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:47918545G>A	uc002let.2	+	7	880	c.696G>A	c.(694-696)CTG>CTA	p.L232L	SKA1_uc002leu.2_Silent_p.L232L|SKA1_uc010xdl.1_Silent_p.L186L	NM_145060	NP_659497	Q96BD8	SKA1_HUMAN	spindle and KT associated 1	232					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding				0						ACGTGTTACTGAATATTTTAC	0.393													0	0	0	0.003271	0	33	82										A	47918545	G	A	47918545	2	1	96	1	0	0	0	0	0	0	0	1	14352	1277	45	1		1	SKA1	18	47918545	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3215953	47918545	30158703	850	29326										
ATP8B1	5205	broad.mit.edu	37	chr18	55322535	55322535	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acatccttatgtaagaccatCggccatgcaccagcagtagc	8	13	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:55322535C>T	uc002lgw.2	-	22	2822	c.2822G>A	c.(2821-2823)CGA>CAA	p.R941Q	uc002lgu.1_Intron|uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	941	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GTAAGACCATCGGCCATGCAC	0.433									Byler_disease				0	0	0	0.007291	0	30	96										T	55322535	C	T	55322535	3	4	96	1	0	0	0	0	1	0	0	0	1194	884	31	1	957	1	ATP8B1	18	55322535	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	7403990	55322535	22754713	851	29327										
ZNF532	55205	broad.mit.edu	37	chr18	56585882	56585882	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctgcctctgaggtgacactGaaagactcgacattcagcca	9	13	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:56585882G>A	uc002lho.2	+	4	910	c.363G>A	c.(361-363)CTG>CTA	p.L121L	ZNF532_uc002lhp.2_Silent_p.L119L|ZNF532_uc010xeg.1_Silent_p.L119L|ZNF532_uc002lhr.2_Silent_p.L119L|ZNF532_uc002lhs.2_Silent_p.L119L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGGTGACACTGAAAGACTCGA	0.493													0	0	0	0.002299	0	21	97										A	56585882	G	A	56585882	2	1	96	1	0	0	0	0	0	0	0	1	17969	1277	45	1		1	ZNF532	18	56585882	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1263347	56585882	21491366	852	29328										
SERPINB8	5271	broad.mit.edu	37	chr18	61647057	61647057	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actttgtttatacaaagacgGagatattcaccgaggtttcc	8	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:61647057G>A	uc002ljv.2	+	3	360	c.191G>A	c.(190-192)GGA>GAA	p.G64E	SERPINB8_uc002ljs.1_Missense_Mutation_p.G64E|SERPINB8_uc002ljt.2_Missense_Mutation_p.G64E|SERPINB8_uc002lju.2_Missense_Mutation_p.G64E|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	64					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				TACAAAGACGGAGATATTCAC	0.433											OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	33	108										A	61647057	G	A	61647057	3	1	96	1	0	0	0	0	1	0	0	0	14107	1174	41	1	197	1	SERPINB8	18	61647057	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	5061175	61647057	16430191	853	29329										
PARD6G	84552	broad.mit.edu	37	chr18	77917935	77917935	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggggtggaagttctgcaggaCgcgcggggcggggggaccca	22	9	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr18:77917935C>T	uc002lny.2	-	3	1016	c.850G>A	c.(850-852)GTC>ATC	p.V284I	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	284					cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)		TTCTGCAGGACGCGCGGGGCG	0.731													0	0	0	0.000602	0	5	18										T	77917935	C	T	77917935	3	4	96	1	0	0	0	0	1	0	0	0	11447	536	19	2	284	2	PARD6G	18	77917935	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	16270878	77917935	159313	854	29330										
ABCA7	10347	broad.mit.edu	37	chr19	1043124	1043124	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccccctggagttgctgtcaGaggccctctgcagtgtcagg	14	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:1043124G>A	uc002lqw.3	+	8	895	c.664G>A	c.(664-666)GAG>AAG	p.E222K	ABCA7_uc010dsb.1_Missense_Mutation_p.E84K	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	222	Extracellular (By similarity).				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTGCTGTCAGAGGCCCTCTG	0.657													0	0	0	0.003163	0	15	68										A	1043124	G	A	1043124	3	1	96	1	0	0	0	0	1	0	0	0	37	943	33	1	690	1	ABCA7	19	1043124	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		1043124	58085859	855	29331										
HMHA1	23526	broad.mit.edu	37	chr19	1068607	1068607	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cggagccaccggagcccactGacagccgccagcccgggcga	14	18	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:1068607G>A	uc002lqz.1	+	2	516	c.285G>A	c.(283-285)CTG>CTA	p.L95L	HMHA1_uc010xgd.1_Silent_p.L111L|HMHA1_uc010xge.1_Intron|HMHA1_uc002lra.1_5'UTR|HMHA1_uc002lrb.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	95					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCCCACTGACAGCCGCCA	0.741													0	0	0	0.00308	0	8	30										A	1068607	G	A	1068607	2	1	96	1	0	0	0	0	0	0	0	1	7240	1277	45	1		1	HMHA1	19	1068607	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	25483	1068607	58060376	856	29332										
ZNF555	148254	broad.mit.edu	37	chr19	2853858	2853858	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ataagtgtaatgtaggacatCctcctgcaaatgaattcatg	8	7	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:2853858C>T	uc002lwo.2	+	4	1884	c.1795C>T	c.(1795-1797)CCT>TCT	p.P599S	ZNF555_uc002lwn.3_Missense_Mutation_p.P598S	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTAGGACATCCTCCTGCAAA	0.388													0	0	0	0.004007	0	15	87										T	2853858	C	T	2853858	3	4	96	1	0	0	0	0	1	0	0	0	17983	855	30	1	1809	1	ZNF555	19	2853858	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1785251	2853858	56275125	857	29333										
ZNF556	80032	broad.mit.edu	37	chr19	2873567	2873567	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttgctgaatcctgctcagaGaaaactctacagagatgtca	8	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:2873567G>C	uc002lwp.1	+	2	164	c.77G>C	c.(76-78)AGA>ACA	p.R26T	ZNF556_uc002lwq.2_Missense_Mutation_p.R26T	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCTCAGAGAAAACTCTAC	0.438													0	0	0	0.008361	0	30	93										C	2873567	G	C	2873567	3	2	96	1	0	0	0	0	1	0	0	0	17984	942	33	1	83	1	ZNF556	19	2873567	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	19709	2873567	56255416	858	29334										
CHAF1A	10036	broad.mit.edu	37	chr19	4408975	4408975	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcagacgatcagggtacttCtgtgcaaagtaaaagccccg	11	10	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:4408975C>T	uc002mal.2	+	3	279	c.179C>T	c.(178-180)TCT>TTT	p.S60F		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	60	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGGTACTTCTGTGCAAAGT	0.473								Chromatin_Structure					0	0	0	0.00361	0	69	145										T	4408975	C	T	4408975	3	4	96	1	0	0	0	0	1	0	0	0	3311	913	32	1	189	1	CHAF1A	19	4408975	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1535408	4408975	54720008	859	29335										
UBXN6	80700	broad.mit.edu	37	chr19	4453979	4453979	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccccaggcccgggactgcttCtgctccagccgggctagggc	14	17	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:4453979C>T	uc002man.1	-	2	291	c.195G>A	c.(193-195)CAG>CAA	p.Q65Q	UBXN6_uc010dty.1_Silent_p.Q12Q|UBXN6_uc002mam.1_Silent_p.Q12Q	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	65						microtubule organizing center|nucleus	protein binding				0						GGGACTGCTTCTGCTCCAGCC	0.672													0	0	0	0.00361	0	48	127										T	4453979	C	T	4453979	2	4	96	1	0	0	0	0	0	0	0	1	16914	912	32	1		1	UBXN6	19	4453979	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	45004	4453979	54675004	860	29336										
LONP1	9361	broad.mit.edu	37	chr19	5694465	5694465	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcatacatgcgctccacggtGaacacgggcttccccacgaa	9	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:5694465G>A	uc002mcx.2	-	15	2286	c.2253C>T	c.(2251-2253)TTC>TTT	p.F751F	LONP1_uc002mcy.2_Silent_p.F687F|LONP1_uc010duh.2_Silent_p.F492F|LONP1_uc010dui.2_Silent_p.F735F|LONP1_uc002mcz.2_Silent_p.F555F	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	751					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GCTCCACGGTGAACACGGGCT	0.642													0	0	0	0.001168	0	5	63										A	5694465	G	A	5694465	2	1	96	1	0	0	0	0	0	0	0	1	8892	1281	45	1		1	LONP1	19	5694465	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1240486	5694465	53434518	861	29337										
EMR1	2015	broad.mit.edu	37	chr19	6928195	6928195	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acagggttcatctggagtttCttggggccagtttgcacagt	13	8	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:6928195C>T	uc002mfw.2	+	17	2300	c.2262C>T	c.(2260-2262)TTC>TTT	p.F754F	EMR1_uc010dvc.2_Silent_p.F689F|EMR1_uc010dvb.2_Silent_p.F702F|EMR1_uc010xji.1_Silent_p.F613F|EMR1_uc010xjj.1_Silent_p.F577F	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	754	Helical; Name=5; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					TCTGGAGTTTCTTGGGGCCAG	0.498													0	0	0	0.00361	0	45	116										T	6928195	C	T	6928195	2	4	96	1	0	0	0	0	0	0	0	1	5104	912	32	1		1	EMR1	19	6928195	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1233730	6928195	52200788	862	29338										
C19orf45	374877	broad.mit.edu	37	chr19	7569023	7569023	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taagggggccccaacaccctCaagtgggactacacgagaca	11	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:7569023C>T	uc002mgm.2	+	3	735	c.594C>T	c.(592-594)CTC>CTT	p.L198L	C19orf45_uc010xjo.1_5'Flank	NM_198534	NP_940936	Q8NA69	CS045_HUMAN	hypothetical protein LOC374877	198											0						CCAACACCCTCAAGTGGGACT	0.547													0	0	0	0.00308	0	7	34										T	7569023	C	T	7569023	2	4	96	1	0	0	0	0	0	0	0	1	1928	813	29	1		1	C19orf45	19	7569023	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	640828	7569023	51559960	863	29339										
MAP2K7	5609	broad.mit.edu	37	chr19	7968919	7968919	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcccggcggaggatcgacctCaacctggatatcagccccca	11	16	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:7968919C>G	uc002mit.2	+	1	155	c.90C>G	c.(88-90)CTC>CTG	p.L30L	MAP2K7_uc002mis.1_Silent_p.L30L|MAP2K7_uc002miv.2_Silent_p.L30L|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Silent_p.L30L|MAP2K7_uc010dvv.2_5'UTR	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	30	Potential.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	GGATCGACCTCAACCTGGATA	0.398													0	0	0	0.004482	0	8	30										G	7968919	C	G	7968919	2	3	96	1	0	0	0	0	0	0	0	1	9242	813	29	1		1	MAP2K7	19	7968919	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	399896	7968919	51160064	864	29340										
ELAVL1	1994	broad.mit.edu	37	chr19	8032455	8032455	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccctcccgacccacctgaatCtctgcgcctggtggtgaacg	10	17	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:8032455C>G	uc002mjb.2	-	5	817	c.650G>C	c.(649-651)AGA>ACA	p.R217T		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	217					3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						CCACCTGAATCTCTGCGCCTG	0.622													0	0	0	0.004482	0	8	24										G	8032455	C	G	8032455	3	3	96	1	0	0	0	0	1	0	0	0	5049	913	32	1	338	1	ELAVL1	19	8032455	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	63536	8032455	51096528	865	29341										
MUC16	94025	broad.mit.edu	37	chr19	9084097	9084097	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tagttggggtctgtggtgaaGaatgaatggctttgctttca	14	4	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:9084097G>A	uc002mkp.2	-	1	7922	c.7718C>T	c.(7717-7719)TCT>TTT	p.S2573F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2573	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGGTGAAGAATGAATGGC	0.502													0	0	0	0.00632	0	28	102										A	9084097	G	A	9084097	3	1	96	1	0	0	0	0	1	0	0	0	9973	942	33	1	36141	1	MUC16	19	9084097	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1051642	9084097	50044886	866	29342										
MUC16	94025	broad.mit.edu	37	chr19	9086405	9086405	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttttcttttcctgtattttCagtgcttcccaaagctgtgg	7	9	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:9086405C>T	uc002mkp.2	-	1	5614	c.5410G>A	c.(5410-5412)GAA>AAA	p.E1804K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1804	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTGTATTTTCAGTGCTTCCC	0.463													0	0	0	0.004656	0	27	69										T	9086405	C	T	9086405	3	4	96	1	0	0	0	0	1	0	0	0	9973	835	29	1	38449	1	MUC16	19	9086405	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2308	9086405	50042578	867	29343										
MUC16	94025	broad.mit.edu	37	chr19	9090786	9090786	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagaggaaattgtgcttctGaccctttcggcacttgtttc	10	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:9090786G>C	uc002mkp.2	-	1	1233	c.1029C>G	c.(1027-1029)GTC>GTG	p.V343V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	343	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGTGCTTCTGACCCTTTCGG	0.507													0	0	0	0.003163	0	16	51										C	9090786	G	C	9090786	2	2	96	1	0	0	0	0	0	0	0	1	9973	1277	45	1		1	MUC16	19	9090786	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4381	9090786	50038197	868	29344										
DNMT1	1786	broad.mit.edu	37	chr19	10250949	10250949	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagccggggttgttcagccgGaacgcctgggccgcagggtc	18	12	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:10250949G>A	uc002mng.2	-	32	3711	c.3531C>T	c.(3529-3531)TTC>TTT	p.F1177F	DNMT1_uc002mne.2_RNA|DNMT1_uc002mnf.2_Silent_p.F101F|DNMT1_uc010xlc.1_Silent_p.F1193F|DNMT1_uc002mnh.2_Silent_p.F1072F|DNMT1_uc010xld.1_Silent_p.F1177F	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1177	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TGTTCAGCCGGAACGCCTGGG	0.612													0	0	0	0.00499	0	17	55										A	10250949	G	A	10250949	2	1	96	1	0	0	0	0	0	0	0	1	4675	1165	41	1		1	DNMT1	19	10250949	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1160163	10250949	48878034	869	29345										
S1PR2	9294	broad.mit.edu	37	chr19	10335096	10335096	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccaaggatgggcaggccaccGaggaccagcgagatgagcca	15	12	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:10335096G>A	uc002mnl.2	-	2	597	c.486C>T	c.(484-486)CTC>CTT	p.L162L		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	162	Helical; Name=4; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						GCAGGCCACCGAGGACCAGCG	0.627													0	0	0	0.002299	0	22	54										A	10335096	G	A	10335096	2	1	96	1	0	0	0	0	0	0	0	1	13794	1045	37	1		1	S1PR2	19	10335096	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	84147	10335096	48793887	870	29346										
TYK2	7297	broad.mit.edu	37	chr19	10461569	10461569	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttctcatggactgtcttcaGaatgggtatgaggttctcga	11	8	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:10461569G>A	uc002moc.3	-	25	3883	c.3505C>T	c.(3505-3507)CTG>TTG	p.L1169L	TYK2_uc010dxe.2_Silent_p.L984L	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	1169	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ACTGTCTTCAGAATGGGTATG	0.557													0	0	0	0.00278	0	23	80										A	10461569	G	A	10461569	2	1	96	1	0	0	0	0	0	0	0	1	16807	933	33	1		1	TYK2	19	10461569	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	126473	10461569	48667414	871	29347										
SMARCA4	6597	broad.mit.edu	37	chr19	11121153	11121153	+	Silent	SNP	G	G	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtggcccatgctgtcactgaGagagtggacaagcagtcagc							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11121153G>A	uc002mqf.3	+	15	2504	c.2220G>A	c.(2218-2220)GAG>GAA	p.E740E	SMARCA4_uc010dxp.2_Silent_p.E740E|SMARCA4_uc010dxo.2_Silent_p.E740E|SMARCA4_uc002mqg.1_Silent_p.E740E|SMARCA4_uc010dxq.2_Silent_p.E740E|SMARCA4_uc010dxr.2_Silent_p.E740E|SMARCA4_uc002mqj.3_Silent_p.E740E|SMARCA4_uc010dxs.2_Silent_p.E740E|SMARCA4_uc010dxt.1_5'Flank	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	740					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGTCACTGAGAGAGTGGACA	0.587			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.002445	0	32	76										A	11121153	G	A	11121153	2	1	96	1	0	0	0	0	0	0	0	1	14770	933	33	1		1	SMARCA4	19	11121153	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	659584	11121153	48007830	872	29348	148	2								
SMARCA4	6597	broad.mit.edu	37	chr19	11121155	11121155	+	Missense_Mutation	SNP	G	G	A													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcccatgctgtcactgagaGagtggacaagcagtcagcgc							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11121155G>A	uc002mqf.3	+	15	2506	c.2222G>A	c.(2221-2223)AGA>AAA	p.R741K	SMARCA4_uc010dxp.2_Missense_Mutation_p.R741K|SMARCA4_uc010dxo.2_Missense_Mutation_p.R741K|SMARCA4_uc002mqg.1_Missense_Mutation_p.R741K|SMARCA4_uc010dxq.2_Missense_Mutation_p.R741K|SMARCA4_uc010dxr.2_Missense_Mutation_p.R741K|SMARCA4_uc002mqj.3_Missense_Mutation_p.R741K|SMARCA4_uc010dxs.2_Missense_Mutation_p.R741K|SMARCA4_uc010dxt.1_5'Flank	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	741					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GTCACTGAGAGAGTGGACAAG	0.582			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.002836	0	33	77										A	11121155	G	A	11121155	3	1	96	1	0	0	0	0	1	0	0	0	14770	942	33	1	2276	1	SMARCA4	19	11121155	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2	11121155	48007828	873	29349	148	2								
KANK2	25959	broad.mit.edu	37	chr19	11277264	11277264	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccgaggatgatgtagggctCtcgtcatctgacattggggc	15	9	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11277264C>G	uc010dxv.2	-	15	3084	c.2526G>C	c.(2524-2526)GAG>GAC	p.E842D	KANK2_uc002mqm.2_Missense_Mutation_p.E850D|KANK2_uc002mqo.3_Missense_Mutation_p.E842D	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	842											0						ATGTAGGGCTCTCGTCATCTG	0.587													0	0	0	0.001368	0	11	71										G	11277264	C	G	11277264	3	3	96	1	0	0	0	0	1	0	0	0	7977	912	32	1	33	1	KANK2	19	11277264	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	156109	11277264	47851719	874	29350										
ZNF441	126068	broad.mit.edu	37	chr19	11892012	11892012	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgcggaaaagccttcaggtCttccaattacattcgagtac	8	10	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11892012C>G	uc010dyj.2	+	4	1567	c.1373C>G	c.(1372-1374)TCT>TGT	p.S458C	ZNF441_uc002msn.3_Missense_Mutation_p.S414C	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	458	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCCTTCAGGTCTTCCAATTAC	0.398													0	0	0	0.005443	0	28	43										G	11892012	C	G	11892012	3	3	96	1	0	0	0	0	1	0	0	0	17911	913	32	1	1387	1	ZNF441	19	11892012	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	614748	11892012	47236971	875	29351										
ZNF441	126068	broad.mit.edu	37	chr19	11892189	11892189	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagctttgattctcccagttCatttcgaagacatgaaagaa	7	8	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:11892189C>T	uc010dyj.2	+	4	1744	c.1550C>T	c.(1549-1551)TCA>TTA	p.S517L	ZNF441_uc002msn.3_Missense_Mutation_p.S473L	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	517	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTCCCAGTTCATTTCGAAGA	0.398													0	0	0	0.001786	0	32	61										T	11892189	C	T	11892189	3	4	96	1	0	0	0	0	1	0	0	0	17911	838	29	1	1564	1	ZNF441	19	11892189	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	177	11892189	47236794	876	29352										
ZNF433	163059	broad.mit.edu	37	chr19	12125889	12125889	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcgcgaggcacatccaaaaGacttcccacactgcttacat	7	14	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12125889G>C	uc002msy.1	-	4	1964	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	uc002msx.1_Intron|ZNF433_uc002msz.1_Missense_Mutation_p.S563C	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	598	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACATCCAAAAGACTTCCCACA	0.468													0	0	0	0.001786	0	30	125										C	12125889	G	C	12125889	3	2	96	1	0	0	0	0	1	0	0	0	17904	942	33	1	232	1	ZNF433	19	12125889	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	233700	12125889	47003094	877	29353										
ZNF433	163059	broad.mit.edu	37	chr19	12126042	12126042	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttccatgaatttgaagctgtGaggcagatctgaaggctttt	11	6	1	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12126042G>T	uc002msy.1	-	4	1811	c.1640C>A	c.(1639-1641)TCA>TAA	p.S547*	uc002msx.1_Intron|ZNF433_uc002msz.1_Nonsense_Mutation_p.S512*	NM_001080411	NP_001073880	Q8N7K0	ZN433_HUMAN	zinc finger protein 433	547	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGAAGCTGTGAGGCAGATCT	0.453													1	0	2.4375e-19	0.007291	3.08979e-19	30	112										T	12126042	G	T	12126042	4	4	96	1	0	0	0	0	0	1	0	0	17904	1294	45	3	385	3	ZNF433	19	12126042	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	153	12126042	47002941	878	29354										
ZNF791	163049	broad.mit.edu	37	chr19	12739289	12739289	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcagatgttccacctccattCaaattcatgaaagaattcat	4	10	4	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12739289C>G	uc002mua.2	+	4	1108	c.946C>G	c.(946-948)CAA>GAA	p.Q316E	ZNF791_uc010xml.1_Missense_Mutation_p.Q284E|ZNF791_uc010dyu.1_Missense_Mutation_p.Q207E|ZNF791_uc010xmm.1_Missense_Mutation_p.Q207E	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	316	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CACCTCCATTCAAATTCATGA	0.393													0	0	0	0.001855	0	11	54										G	12739289	C	G	12739289	3	3	96	1	0	0	0	0	1	0	0	0	18160	827	29	1	960	1	ZNF791	19	12739289	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	613247	12739289	46389694	879	29355										
JUNB	3726	broad.mit.edu	37	chr19	12903392	12903392	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atggaagaccaagagcgcatCaaagtggagcgcaagcggct	14	9	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:12903392C>G	uc002mvc.2	+	1	1083	c.807C>G	c.(805-807)ATC>ATG	p.I269M	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	269						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						AAGAGCGCATCAAAGTGGAGC	0.682													0	0	0	0.004672	0	2	8										G	12903392	C	G	12903392	3	3	96	1	0	0	0	0	1	0	0	0	7970	816	29	1	809	1	JUNB	19	12903392	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	164103	12903392	46225591	880	29356										
GCDH	2639	broad.mit.edu	37	chr19	13007200	13007200	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggacggtgtggaggtgccaGaggagaatgtgctccctggt	18	7	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:13007200G>C	uc002mvq.2	+	8	894	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	GCDH_uc010xms.1_Missense_Mutation_p.E240Q|GCDH_uc002mvp.2_Missense_Mutation_p.E273Q|GCDH_uc010xmt.1_Missense_Mutation_p.E107Q|GCDH_uc010xmu.1_Missense_Mutation_p.E229Q	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	273					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						GGAGGTGCCAGAGGAGAATGT	0.632													0	0	0	0.001984	0	5	35										C	13007200	G	C	13007200	3	2	96	1	0	0	0	0	1	0	0	0	6287	943	33	1	843	1	GCDH	19	13007200	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	103808	13007200	46121783	881	29357										
TRMT1	55621	broad.mit.edu	37	chr19	13218411	13218411	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggctccacactgagaatgcgGaacgctgggctagtctctga	13	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:13218411G>A	uc002mwj.2	-	13	1810	c.1560C>T	c.(1558-1560)TTC>TTT	p.F520F	TRMT1_uc010xmy.1_Silent_p.F124F|TRMT1_uc002mwk.2_Silent_p.F491F|TRMT1_uc002mwl.3_Silent_p.F520F|TRMT1_uc010xmz.1_Silent_p.F306F	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	520							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGAGAATGCGGAACGCTGGGC	0.582													0	0	0	0.006214	0	8	11										A	13218411	G	A	13218411	2	1	96	1	0	0	0	0	0	0	0	1	16558	1165	41	1		1	TRMT1	19	13218411	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	211211	13218411	45910572	882	29358										
BRD4	23476	broad.mit.edu	37	chr19	15349940	15349940	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgagccttcagggccttctCacgctcctctttctcccgag	8	17	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:15349940C>T	uc002nar.2	-	18	3934	c.3712G>A	c.(3712-3714)GAG>AAG	p.E1238K		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1238					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AGGGCCTTCTCACGCTCCTCT	0.662			T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.001368	0	12	11										T	15349940	C	T	15349940	3	4	96	1	0	0	0	0	1	0	0	0	1504	835	29	1	388	1	BRD4	19	15349940	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2131529	15349940	43779043	883	29359										
CYP4F3	4051	broad.mit.edu	37	chr19	15760750	15760750	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agtgaatatattgccgccatCttggagctcagtgcccttgt	10	10	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:15760750C>G	uc002nbj.2	+	7	725	c.675C>G	c.(673-675)ATC>ATG	p.I225M	CYP4F3_uc010xok.1_Missense_Mutation_p.I225M|CYP4F3_uc010xol.1_Missense_Mutation_p.I225M|CYP4F3_uc010xom.1_Missense_Mutation_p.I76M|CYP4F3_uc002nbk.2_Missense_Mutation_p.I225M|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	225					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TTGCCGCCATCTTGGAGCTCA	0.522													0	0	0	0.00361	0	63	221										G	15760750	C	G	15760750	3	3	96	1	0	0	0	0	1	0	0	0	4190	903	32	1	697	1	CYP4F3	19	15760750	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	410810	15760750	43368233	884	29360										
GTPBP3	84705	broad.mit.edu	37	chr19	17452360	17452360	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accacctccagggttgcctgGatgccctcggccactacaag	10	16	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:17452360G>A	uc010eas.2	+	9	1392	c.1327G>A	c.(1327-1329)GAT>AAT	p.D443N	GTPBP3_uc010xpo.1_Missense_Mutation_p.D465N|GTPBP3_uc002ngh.3_Missense_Mutation_p.D422N|GTPBP3_uc002ngg.3_Missense_Mutation_p.D475N|GTPBP3_uc002ngi.3_Missense_Mutation_p.D109N	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V	443					tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						GGGTTGCCTGGATGCCCTCGG	0.642													0	0	0	0.008291	0	11	72										A	17452360	G	A	17452360	3	1	96	1	0	0	0	0	1	0	0	0	6881	1174	41	1	1453	1	GTPBP3	19	17452360	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1691610	17452360	41676623	885	29361										
PGLS	25796	broad.mit.edu	37	chr19	17631815	17631815	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctggtccagccccacaccggGaaactgtgctggttcttgga	12	13	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:17631815G>A	uc002ngw.2	+	5	752	c.702G>A	c.(700-702)GGG>GGA	p.G234G	FAM129C_uc010xpq.1_5'Flank|FAM129C_uc010xpr.1_5'Flank	NM_012088	NP_036220	O95336	6PGL_HUMAN	6-phosphogluconolactonase	234						cytosol	6-phosphogluconolactonase activity				0						CCCACACCGGGAAACTGTGCT	0.652													0	0	0	0.000602	0	5	9										A	17631815	G	A	17631815	2	1	96	1	0	0	0	0	0	0	0	1	11792	1161	41	1		1	PGLS	19	17631815	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	179455	17631815	41497168	886	29362										
MAP1S	55201	broad.mit.edu	37	chr19	17838864	17838864	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccaaaaccaaggggcttgctGgtggggaccgtgccagccga	15	12	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:17838864G>A	uc002nhe.1	+	5	2680	c.2671G>A	c.(2671-2673)GGT>AGT	p.G891S	MAP1S_uc010eba.1_Intron|MAP1S_uc002nhf.1_Missense_Mutation_p.G139S|MAP1S_uc010xpv.1_Missense_Mutation_p.G865S	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	891	Necessary for interaction with RASSF1 isoform A and isoform C.|Necessary for association with microtubules.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GGGGCTTGCTGGTGGGGACCG	0.682													0	0	0	0.008291	0	10	26										A	17838864	G	A	17838864	3	1	96	1	0	0	0	0	1	0	0	0	9234	1348	47	2	2689	2	MAP1S	19	17838864	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	207049	17838864	41290119	887	29363										
UBA52	7311	broad.mit.edu	37	chr19	18684102	18684102	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgcctcccttcctcctgcaGacgcaaacatgcagatcttt	6	16	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:18684102G>A	uc002njr.2	+	2	107	c.-7_splice	c.e2-1		UBA52_uc002njs.2_Splice_Site|UBA52_uc002njt.2_Splice_Site	NM_001033930	NP_001029102	P62987	RL40_HUMAN	ubiquitin and ribosomal protein L40 precursor						activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome				0						TCCTCCTGCAGACGCAAACAT	0.517													0	0	0	0.001984	0	6	28										A	18684102	G	A	18684102	5	1	96	1	0	0	0	0	0	0	1	0	16828	956	33	1		1	UBA52	19	18684102	Splice_Site	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	845238	18684102	40444881	888	29364										
NCAN	1463	broad.mit.edu	37	chr19	19334931	19334931	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagccatcattgcagcccctCggcatctacaggctgccttt	8	16	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:19334931C>G	uc002nlz.2	+	4	676	c.577C>G	c.(577-579)CGG>GGG	p.R193G	NCAN_uc010ecc.1_5'Flank	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	193	Link 1.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TGCAGCCCCTCGGCATCTACA	0.602													0	0	0	0.008291	0	11	41										G	19334931	C	G	19334931	3	3	96	1	0	0	0	0	1	0	0	0	10204	875	31	1	587	1	NCAN	19	19334931	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	650829	19334931	39794052	889	29365										
ZNF99	7652	broad.mit.edu	37	chr19	22940381	22940381	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tatgaattatcttatgttttCtaagggctgagaaatgctta	8	4	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:22940381C>T	uc010xrh.1	-	5	2057	c.2057G>A	c.(2056-2058)AGA>AAA	p.R686K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CTTATGTTTTCTAAGGGCTGA	0.348													0	0	0	0.008291	0	11	77										T	22940381	C	T	22940381	3	4	96	1	0	0	0	0	1	0	0	0	18201	913	32	1	1067	1	ZNF99	19	22940381	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3605450	22940381	36188602	890	29366										
ZNF99	7652	broad.mit.edu	37	chr19	22940551	22940551	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgaattatctcatgttttctAagagttgaggactggctaaa	9	5	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:22940551A>C	uc010xrh.1	-	5	1887	c.1887T>G	c.(1885-1887)CTT>CTG	p.L629L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATGTTTTCTAAGAGTTGAGG	0.363													0	0	0	0.003163	0	15	64										C	22940551	A	C	22940551	2	2	96	1	0	0	0	0	0	0	0	1	18201	349	13	5		5	ZNF99	19	22940551	Silent	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	170	22940551	36188432	891	29367										
ZNF91	7644	broad.mit.edu	37	chr19	23578152	23578152	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctaggcttccaggggttcctGgcatcttagctgtggctctc	12	12	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:23578152G>A	uc002nre.2	-	1	118	c.5C>T	c.(4-6)CCA>CTA	p.P2L	ZNF91_uc010xrj.1_Missense_Mutation_p.P2L	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	2						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AGGGGTTCCTGGCATCTTAGC	0.612													0	0	0	0.004656	0	21	78										A	23578152	G	A	23578152	3	1	96	1	0	0	0	0	1	0	0	0	18197	1348	47	2	3586	2	ZNF91	19	23578152	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	637601	23578152	35550831	892	29368										
ZNF507	22847	broad.mit.edu	37	chr19	32873422	32873422	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atcctccttctttgaagtctCatatgtggaaacatgcaagt	7	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:32873422C>A	uc002nte.2	+	6	2682	c.2410C>A	c.(2410-2412)CAT>AAT	p.H804N	ZNF507_uc002ntd.2_Missense_Mutation_p.H804N	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	804	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					TTTGAAGTCTCATATGTGGAA	0.443													1	0	6.17869e-53	0.00361	7.94403e-53	108	338										A	32873422	C	A	32873422	3	1	96	1	0	0	0	0	1	0	0	0	17950	826	29	3	2424	3	ZNF507	19	32873422	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9295270	32873422	26255561	893	29369										
DPY19L3	147991	broad.mit.edu	37	chr19	32973094	32973094	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctacgtggcctacttcaccaGagtgttccagaacaaaacct	7	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:32973094G>C	uc002ntg.2	+	19	2275	c.2099G>C	c.(2098-2100)AGA>ACA	p.R700T	DPY19L3_uc002nth.1_Missense_Mutation_p.R700T|DPY19L3_uc002nti.1_RNA|DPY19L3_uc002ntj.1_Missense_Mutation_p.R122T	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	700						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TACTTCACCAGAGTGTTCCAG	0.478													0	0	0	0.00361	0	114	199										C	32973094	G	C	32973094	3	2	96	1	0	0	0	0	1	0	0	0	4742	942	33	1	2169	1	DPY19L3	19	32973094	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	99672	32973094	26155889	894	29370										
RHPN2	85415	broad.mit.edu	37	chr19	33490610	33490610	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccagatccgtgcctggcttCactgcaaagagaaccacagg	10	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:33490610C>T	uc002nuf.2	-	10	1173	c.1107G>A	c.(1105-1107)GTG>GTA	p.V369V	RHPN2_uc010xro.1_Silent_p.V218V|RHPN2_uc002nue.2_Silent_p.V99V	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	369	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					TGCCTGGCTTCACTGCAAAGA	0.542													0	0	0	0.002096	0	27	64										T	33490610	C	T	33490610	2	4	96	1	0	0	0	0	0	0	0	1	13351	840	29	1		1	RHPN2	19	33490610	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	517516	33490610	25638373	895	29371										
KIAA0355	9710	broad.mit.edu	37	chr19	34791501	34791501	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctgagctgggccgagcactGagtgctcccctggcatccac	12	16	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:34791501G>A	uc002nvd.3	+	2	982	c.123G>A	c.(121-123)CTG>CTA	p.L41L	KIAA0355_uc010edk.1_Silent_p.L31L	NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	41										ovary(1)	1	Esophageal squamous(110;0.162)					GCCGAGCACTGAGTGCTCCCC	0.637													0	0	0	0.002299	0	24	65										A	34791501	G	A	34791501	2	1	96	1	0	0	0	0	0	0	0	1	8170	1277	45	1		1	KIAA0355	19	34791501	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1300891	34791501	24337482	896	29372										
SCN1B	6324	broad.mit.edu	37	chr19	35523533	35523533	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctcctgcaagcgccgcagcGagaccaacgctgagaccttc	10	16	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:35523533G>C	uc002nxp.2	+	2	333	c.142G>C	c.(142-144)GAG>CAG	p.E48Q	SCN1B_uc002nxo.1_Missense_Mutation_p.E48Q|SCN1B_uc010xsg.1_Missense_Mutation_p.E48Q	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	48	Extracellular (Potential).|Ig-like C2-type.				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCGCCGCAGCGAGACCAACGC	0.627													0	0	0	0.00361	0	43	190										C	35523533	G	C	35523533	3	2	96	1	0	0	0	0	1	0	0	0	13915	1059	37	1	148	1	SCN1B	19	35523533	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	732032	35523533	23605450	897	29373										
LSR	51599	broad.mit.edu	37	chr19	35758329	35758329	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcagccgggacgacctctatGaccaagacgactcgagggac	13	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:35758329G>A	uc002nyl.2	+	9	1829	c.1606G>A	c.(1606-1608)GAC>AAC	p.D536N	LSR_uc002nym.2_Missense_Mutation_p.D517N|LSR_uc002nyn.2_Missense_Mutation_p.D468N|LSR_uc002nyo.2_Missense_Mutation_p.D516N|LSR_uc010xsr.1_Missense_Mutation_p.D428N|LSR_uc002nyp.2_Missense_Mutation_p.D478N|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	536	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CGACCTCTATGACCAAGACGA	0.687													0	0	0	0.004482	0	9	27										A	35758329	G	A	35758329	3	1	96	1	0	0	0	0	1	0	0	0	9064	1290	45	1	1640	1	LSR	19	35758329	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	234796	35758329	23370654	898	29374										
ATP4A	495	broad.mit.edu	37	chr19	36054367	36054367	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccttcttcttcttgctcatCttggcagccatgtccccgcc	7	17	5	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36054367C>T	uc002oal.1	-	2	104	c.75G>A	c.(73-75)AAG>AAA	p.K25K		NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	25	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TCTTGCTCATCTTGGCAGCCA	0.577													0	0	0	0.00361	0	75	280										T	36054367	C	T	36054367	2	4	96	1	0	0	0	0	0	0	0	1	1145	912	32	1		1	ATP4A	19	36054367	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	296038	36054367	23074616	899	29375										
MLL4	9757	broad.mit.edu	37	chr19	36211234	36211234	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gactcgaatcaggtcaaggtCaaggtcaacatgaggaaagt	12	7	4	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36211234C>T	uc010eei.2	+	3	985	c.985C>T	c.(985-987)CAA>TAA	p.Q329*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	329					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGTCAAGGTCAAGGTCAACA	0.512													0	0	0	0.000602	0	5	26										T	36211234	C	T	36211234	4	4	96	1	0	0	0	0	0	1	0	0	9623	827	29	1	995	1	MLL4	19	36211234	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	156867	36211234	22917749	900	29376										
TMEM149	79713	broad.mit.edu	37	chr19	36230880	36230880	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggcctgctgagggacaggcTcaggggtcctccaggcaatg	16	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36230880T>C	uc002obc.2	-	4	553	c.452A>G	c.(451-453)GAG>GGG	p.E151G	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Missense_Mutation_p.E151G|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.E231G	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	151	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGGACAGGCTCAGGGGTCCT	0.632													0	0	0	0.006999	0	40	51										C	36230880	T	C	36230880	3	2	96	1	0	0	0	0	1	0	0	0	16059	1551	54	5	623	5	TMEM149	19	36230880	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	19646	36230880	22898103	901	29377										
TMEM149	79713	broad.mit.edu	37	chr19	36230990	36230990	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccttggcagggaccggcctCtggggataaggggttggagt	18	9	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:36230990C>T	uc002obc.2	-	4	444	c.343_splice	c.e4-1	p.R115_splice	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Splice_Site_p.R115_splice|TMEM149_uc010xsy.1_Intron|TMEM149_uc010eej.2_Splice_Site_p.R195_splice	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor							integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGACCGGCCTCTGGGGATAAG	0.607													0	0	0	0.000602	0	4	46										T	36230990	C	T	36230990	5	4	96	1	0	0	0	0	0	0	1	0	16059	927	32	1	733	1	TMEM149	19	36230990	Splice_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	110	36230990	22897993	902	29378										
SPRED3	399473	broad.mit.edu	37	chr19	38882867	38882867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccaggctcactcaccccctCctcctcctcctcctcctcct	2	26	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:38882867C>T	uc002oim.2	+	3	366	c.362C>T	c.(361-363)TCC>TTC	p.S121F	SPRED3_uc002oil.1_Missense_Mutation_p.S121F	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	121	Ser-rich.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTCAccccctcctcctcctcc	0.537													0	0	0	0.00245	0	15	20										T	38882867	C	T	38882867	3	4	96	1	0	0	0	0	1	0	0	0	15093	855	30	1	372	1	SPRED3	19	38882867	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2651877	38882867	20246116	903	29379										
RYR1	6261	broad.mit.edu	37	chr19	39017663	39017663	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgaggaggtccgggaatttCtgcacaacaaccttcacctt	9	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39017663C>G	uc002oit.2	+	72	10787	c.10657C>G	c.(10657-10659)CTG>GTG	p.L3553V	RYR1_uc002oiu.2_Missense_Mutation_p.L3548V|RYR1_uc002oiv.1_Missense_Mutation_p.L468V|RYR1_uc010xuf.1_Missense_Mutation_p.L473V	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3553					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCGGGAATTTCTGCACAACAA	0.507													0	0	0	0.000978	0	11	88										G	39017663	C	G	39017663	3	3	96	1	0	0	0	0	1	0	0	0	13768	912	32	1	10943	1	RYR1	19	39017663	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	134796	39017663	20111320	904	29380										
RYR1	6261	broad.mit.edu	37	chr19	39034011	39034011	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccagaactacctacggacacAgacagggaacacgaccacta	8	14	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39034011A>C	uc002oit.2	+	85	11844	c.11714A>C	c.(11713-11715)CAG>CCG	p.Q3905P	RYR1_uc002oiu.2_Missense_Mutation_p.Q3900P|RYR1_uc002oiv.1_Missense_Mutation_p.Q814P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3905					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTACGGACACAGACAGGGAAC	0.488													0	0	0	0.007291	0	28	153										C	39034011	A	C	39034011	3	2	96	1	0	0	0	0	1	0	0	0	13768	188	7	5	12052	5	RYR1	19	39034011	Missense_Mutation	SNP	A	TCGA-G2-A2EO-01A-11D-A17V-08	16348	39034011	20094972	905	29381										
LRFN1	57622	broad.mit.edu	37	chr19	39804678	39804678	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgagcacggagttcgaggtGagctcggctgccacgagccg	16	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39804678G>C	uc002okw.2	-	1	1299	c.1299C>G	c.(1297-1299)CTC>CTG	p.L433L		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	433	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			AGTTCGAGGTGAGCTCGGCTG	0.652													0	0	0	0.00308	0	6	44										C	39804678	G	C	39804678	2	2	96	1	0	0	0	0	0	0	0	1	8937	1277	45	1		1	LRFN1	19	39804678	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	770667	39804678	19324305	906	29382										
LRFN1	57622	broad.mit.edu	37	chr19	39804803	39804803	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agccggcgggggtgccatcaGaggcagaggtaccacgcaca	16	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39804803G>C	uc002okw.2	-	1	1174	c.1174C>G	c.(1174-1176)CTG>GTG	p.L392V		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	392	Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGTGCCATCAGAGGCAGAGGT	0.672													0	0	0	0.001984	0	7	41										C	39804803	G	C	39804803	3	2	96	1	0	0	0	0	1	0	0	0	8937	933	33	1	1149	1	LRFN1	19	39804803	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	125	39804803	19324180	907	29383										
MED29	55588	broad.mit.edu	37	chr19	39882056	39882056	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcacttccggcggtctacgcGaggaagatggctgcatccca	13	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:39882056G>C	uc002olf.2	+	1	94	c.57G>C	c.(55-57)GCG>GCC	p.A19A	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Silent_p.A19A|MED29_uc010xux.1_RNA	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CGGTCTACGCGAGGAAGATGG	0.617													0	0	0	0.004482	0	9	33										C	39882056	G	C	39882056	2	2	96	1	0	0	0	0	0	0	0	1	9447	1045	37	1		1	MED29	19	39882056	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	77253	39882056	19246927	908	29384										
PRX	57716	broad.mit.edu	37	chr19	40902007	40902007	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttccggcagccgaatctctGacactttcggcagctgcacc	9	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:40902007G>C	uc002onr.2	-	7	2521	c.2252C>G	c.(2251-2253)TCA>TGA	p.S751*	PRX_uc002onq.2_Nonsense_Mutation_p.S612*|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	751	51.|55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCGAATCTCTGACACTTTCGG	0.592													0	0	0	0.00361	0	60	236										C	40902007	G	C	40902007	4	2	96	1	0	0	0	0	0	1	0	0	12642	1294	45	1	2137	1	PRX	19	40902007	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1019951	40902007	18226976	909	29385										
SPTBN4	57731	broad.mit.edu	37	chr19	41029487	41029487	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggctgcagagggcctgctGaggcagggcaacatctacgg	16	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:41029487G>C	uc002ony.2	+	17	3884	c.3798G>C	c.(3796-3798)CTG>CTC	p.L1266L	SPTBN4_uc002onx.2_Silent_p.L1266L|SPTBN4_uc002onz.2_Silent_p.L1266L|SPTBN4_uc010egx.2_5'UTR	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1266	Spectrin 10.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGGCCTGCTGAGGCAGGGCA	0.632													0	0	0	0.00333	0	23	74										C	41029487	G	C	41029487	2	2	96	1	0	0	0	0	0	0	0	1	15120	1277	45	1		1	SPTBN4	19	41029487	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	127480	41029487	18099496	910	29386										
CYP2A7	1549	broad.mit.edu	37	chr19	41384835	41384835	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	catcaccgaagagaacatctCatagagctggggttgcagag	12	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:41384835C>G	uc002opm.2	-	5	1203	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	CYP2A7_uc002opo.2_Missense_Mutation_p.E221Q|CYP2A7_uc002opn.2_Missense_Mutation_p.E170Q	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	221						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GAGAACATCTCATAGAGCTGG	0.527													0	0	0	0.006122	0	15	46										G	41384835	C	G	41384835	3	3	96	1	0	0	0	0	1	0	0	0	4163	835	29	1	843	1	CYP2A7	19	41384835	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	355348	41384835	17744148	911	29387										
CIC	23152	broad.mit.edu	37	chr19	42791575	42791575	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggaacgggactcatcttctGagaaggatggacgcagcccc	13	11	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:42791575G>C	uc002otf.1	+	4	596	c.556G>C	c.(556-558)GAG>CAG	p.E186Q		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CTCATCTTCTGAGAAGGATGG	0.597			T	DUX4	soft tissue sarcoma								0	0	0	0.00632	0	26	154										C	42791575	G	C	42791575	3	2	96	1	0	0	0	0	1	0	0	0	3424	1291	45	1	570	1	CIC	19	42791575	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1406740	42791575	16337408	912	29388										
BCL3	602	broad.mit.edu	37	chr19	45262794	45262794	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cttccttccccatctccaccCgccttcctgccctttgctgg	5	21	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:45262794C>T	uc010xxe.1	+	9	1357	c.1287C>T	c.(1285-1287)CCC>CCT	p.P429P		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	429	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CATCTCCACCCGCCTTCCTGC	0.682			T	IGH@	CLL 								0	0	0	0.001523	0	19	345										T	45262794	C	T	45262794	2	4	96	1	0	0	0	0	0	0	0	1	1375	639	23	2		2	BCL3	19	45262794	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2471219	45262794	13866189	913	29389										
FOSB	2354	broad.mit.edu	37	chr19	45976195	45976195	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgcccggaggtctccgcgttCgccggcgcccaacgcaccag	13	18	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:45976195C>T	uc002pbx.3	+	4	1534	c.942C>T	c.(940-942)TTC>TTT	p.F314F	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Silent_p.F239F|FOSB_uc002pby.3_Silent_p.F278F|FOSB_uc010eka.1_3'UTR|FOSB_uc010ekb.1_3'UTR|FOSB_uc010ekc.1_3'UTR|FOSB_uc010ekf.2_Silent_p.F275F|FOSB_uc010ekd.1_3'UTR|FOSB_uc010ekg.2_Silent_p.F171F|FOSB_uc002pca.3_Silent_p.F265F	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	314					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		TCTCCGCGTTCGCCGGCGCCC	0.577													0	0	0	0.00333	0	25	169										T	45976195	C	T	45976195	2	4	96	1	0	0	0	0	0	0	0	1	5986	883	31	1		1	FOSB	19	45976195	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	713401	45976195	13152788	914	29390										
FBXO46	23403	broad.mit.edu	37	chr19	46215530	46215530	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccgcggttctggagaaagaaGagctggcccggaggcggcgg	19	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:46215530G>T	uc002pcy.2	-	2	1349	c.1224C>A	c.(1222-1224)CTC>CTA	p.L408L	FBXO46_uc002pcz.2_Silent_p.L408L	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	408							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GGAGAAAGAAGAGCTGGCCCG	0.701													1	0	2.52707e-12	0.006214	3.15063e-12	8	62										T	46215530	G	T	46215530	2	4	96	1	0	0	0	0	0	0	0	1	5755	929	33	3		3	FBXO46	19	46215530	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	239335	46215530	12913453	915	29391										
NPAS1	4861	broad.mit.edu	37	chr19	47535945	47535945	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgaaccaggaaggaaaattCctctacatctcagagacagt	8	9	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47535945C>G	uc002pfw.2	+	5	673	c.477C>G	c.(475-477)TTC>TTG	p.F159L	NPAS1_uc002pfx.2_5'UTR|NPAS1_uc002pfy.2_Missense_Mutation_p.F159L|NPAS1_uc010xyj.1_5'Flank	NM_002517	NP_002508	Q99742	NPAS1_HUMAN	neuronal PAS domain protein 1	159	PAS 1.				central nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0		all_cancers(25;4.31e-08)|all_epithelial(76;2.96e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.102)		all cancers(93;6.02e-05)|OV - Ovarian serous cystadenocarcinoma(262;7.35e-05)|Epithelial(262;0.00389)|GBM - Glioblastoma multiforme(486;0.0252)		AAGGAAAATTCCTCTACATCT	0.577											OREG0025585	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	25	101										G	47535945	C	G	47535945	3	3	96	1	0	0	0	0	1	0	0	0	10562	854	30	1	491	1	NPAS1	19	47535945	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1320415	47535945	11593038	916	29392										
NPAS1	4861	broad.mit.edu	37	chr19	47535976	47535976	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagagacagtctccatctatCtgggtctctcacaggtaagg	10	11	5	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47535976C>T	uc002pfw.2	+	5	704	c.508C>T	c.(508-510)CTG>TTG	p.L170L	NPAS1_uc002pfx.2_5'UTR|NPAS1_uc002pfy.2_Silent_p.L170L|NPAS1_uc010xyj.1_5'Flank	NM_002517	NP_002508	Q99742	NPAS1_HUMAN	neuronal PAS domain protein 1	170	PAS 1.				central nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0		all_cancers(25;4.31e-08)|all_epithelial(76;2.96e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.102)		all cancers(93;6.02e-05)|OV - Ovarian serous cystadenocarcinoma(262;7.35e-05)|Epithelial(262;0.00389)|GBM - Glioblastoma multiforme(486;0.0252)		CTCCATCTATCTGGGTCTCTC	0.552											OREG0025585	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001523	0	20	75										T	47535976	C	T	47535976	2	4	96	1	0	0	0	0	0	0	0	1	10562	912	32	1		1	NPAS1	19	47535976	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	31	47535976	11593007	917	29393										
DHX34	9704	broad.mit.edu	37	chr19	47856631	47856631	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctgttcttggccctgccaCgcggggctctcagggactgg	14	14	3	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47856631C>T	uc010xyn.1	+	2	685	c.344C>T	c.(343-345)ACG>ATG	p.T115M	DHX34_uc010elc.1_Missense_Mutation_p.T115M	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	115						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GGCCCTGCCACGCGGGGCTCT	0.642													0	0	0	0.005443	0	27	161										T	47856631	C	T	47856631	3	4	96	1	0	0	0	0	1	0	0	0	4507	536	19	2	346	2	DHX34	19	47856631	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	320655	47856631	11272352	918	29394										
NAPA	8775	broad.mit.edu	37	chr19	47998837	47998837	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tagatctcgattgctcgcatCaaacagttaatggcctctgg	9	10	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:47998837C>G	uc002pha.1	-	4	612	c.312G>C	c.(310-312)TTG>TTC	p.L104F	uc002pgz.1_RNA|NAPA_uc002phb.1_Missense_Mutation_p.L65F|NAPA_uc002phc.1_5'UTR|NAPA_uc002phd.1_Missense_Mutation_p.L104F|NAPA_uc010elf.1_5'UTR	NM_003827	NP_003818	P54920	SNAA_HUMAN	N-ethylmaleimide-sensitive factor attachment	104					cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)		TTGCTCGCATCAAACAGTTAA	0.567													0	0	0	0.001523	0	19	216										G	47998837	C	G	47998837	3	3	96	1	0	0	0	0	1	0	0	0	10161	825	29	1	607	1	NAPA	19	47998837	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	142206	47998837	11130146	919	29395										
CCDC114	93233	broad.mit.edu	37	chr19	48801464	48801464	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggaaggcctgcactgtcagGagctccaccagccgcttctc	11	15	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:48801464G>T	uc002pir.2	-	11	1946	c.1263C>A	c.(1261-1263)CTC>CTA	p.L421L	CCDC114_uc002piq.2_Silent_p.L230L|CCDC114_uc002pio.2_Silent_p.L458L|CCDC114_uc002pis.1_Silent_p.L101L|CCDC114_uc002pit.1_Silent_p.L458L	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	421										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		GCACTGTCAGGAGCTCCACCA	0.652													1	0	3.27435e-08	0.00245	3.98906e-08	15	56										T	48801464	G	T	48801464	2	4	96	1	0	0	0	0	0	0	0	1	2751	1161	41	3		3	CCDC114	19	48801464	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	802627	48801464	10327519	920	29396										
RASIP1	54922	broad.mit.edu	37	chr19	49238679	49238679	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gccgcaaagacaagttttctGagcgctccttgcctccagac	9	14	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49238679G>A	uc002pki.2	-	4	1150	c.953C>T	c.(952-954)TCA>TTA	p.S318L		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	318					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CAAGTTTTCTGAGCGCTCCTT	0.701													0	0	0	0.004482	0	8	24										A	49238679	G	A	49238679	3	1	96	1	0	0	0	0	1	0	0	0	13078	1294	45	1	1974	1	RASIP1	19	49238679	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	437215	49238679	9890304	921	29397										
DHDH	27294	broad.mit.edu	37	chr19	49436972	49436972	+	Translation_Start_Site	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggtgccgagggctccgcatCgcaaccatggcgctgcgctg	15	14	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49436972C>G	uc002ple.1	+	1	34	c.-6C>G	c.(-8--4)ATCGC>ATGGC			NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase						carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		GGCTCCGCATCGCAACCATGG	0.682													0	0	0	0.008361	0	25	54										G	49436972	C	G	49436972	1	3	96	1	0	0	0	0	0	0	0	0	4479	899	31	1		1	DHDH	19	49436972	Translation_Start_Site	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	198293	49436972	9692011	922	29398										
TRPM4	54795	broad.mit.edu	37	chr19	49661463	49661463	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccccagagctggatccccaaGatcttcaagaagaagacctg	9	13	2	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49661463G>T	uc002pmw.2	+	2	111	c.39G>T	c.(37-39)AAG>AAT	p.K13N	TRPM4_uc010emu.2_Missense_Mutation_p.K13N|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Missense_Mutation_p.K13N|TRPM4_uc010yal.1_5'UTR|HRC_uc002pmv.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	13	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGATCCCCAAGATCTTCAAGA	0.602													1	0	3.19358e-47	0.00361	4.09871e-47	73	333										T	49661463	G	T	49661463	3	4	96	1	0	0	0	0	1	0	0	0	16585	933	33	3	45	3	TRPM4	19	49661463	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	224491	49661463	9467520	923	29399										
TRPM4	54795	broad.mit.edu	37	chr19	49661514	49661514	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atagttgactccacagatccGgggtgaggagttcgcccctg	13	11	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:49661514G>A	uc002pmw.2	+	2	162	c.90G>A	c.(88-90)CCG>CCA	p.P30P	TRPM4_uc010emu.2_Silent_p.P30P|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Silent_p.P30P|TRPM4_uc010yal.1_5'UTR|HRC_uc002pmv.2_5'Flank	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	30	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCACAGATCCGGGGTGAGGAG	0.627													0	0	0	0.00361	0	55	317										A	49661514	G	A	49661514	2	1	96	1	0	0	0	0	0	0	0	1	16585	1103	39	2		2	TRPM4	19	49661514	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	51	49661514	9467469	924	29400										
FCGRT	2217	broad.mit.edu	37	chr19	50029338	50029338	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggggaggcccaggatgctGatttgaaggatgtaaatgtg	16	5	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:50029338G>A	uc002poe.2	+	7	1546	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N	FCGRT_uc002pod.2_RNA|FCGRT_uc002pog.2_Missense_Mutation_p.D354N|FCGRT_uc002poi.2_RNA|RCN3_uc002poj.2_5'Flank	NM_001136019	NP_001129491	P55899	FCGRN_HUMAN	Fc fragment of IgG, receptor, transporter, alpha	354	Cytoplasmic (Potential).				antigen processing and presentation|female pregnancy|immune response	integral to membrane|MHC class I protein complex	IgG binding|receptor activity			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00291)|GBM - Glioblastoma multiforme(134;0.0156)		CCAGGATGCTGATTTGAAGGA	0.577													0	0	0	0.003755	0	33	311										A	50029338	G	A	50029338	3	1	96	1	0	0	0	0	1	0	0	0	5786	1290	45	1	1082	1	FCGRT	19	50029338	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	367824	50029338	9099645	925	29401										
SHANK1	50944	broad.mit.edu	37	chr19	51165245	51165245	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctctccaggaagaatttgaGagcccggtcgatgttcatgc	11	11	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:51165245G>A	uc002psx.1	-	23	6482	c.6463C>T	c.(6463-6465)CTC>TTC	p.L2155F	SHANK1_uc002psw.1_Missense_Mutation_p.L1539F	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2155	SAM.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AAGAATTTGAGAGCCCGGTCG	0.612													0	0	0	0.005443	0	26	89										A	51165245	G	A	51165245	3	1	96	1	0	0	0	0	1	0	0	0	14264	942	33	1	26	1	SHANK1	19	51165245	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1135907	51165245	7963738	926	29402										
ACPT	93650	broad.mit.edu	37	chr19	51293713	51293713	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggccaccctgctggacctctCctgctgctgctgctgctggt	12	16	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:51293713C>G	uc002pta.1	+	1	42	c.42C>G	c.(40-42)CTC>CTG	p.L14L		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	14						integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTGGACCTCTCctgctgctgc	0.627													0	0	0	0.000602	0	4	17										G	51293713	C	G	51293713	2	3	96	1	0	0	0	0	0	0	0	1	168	842	30	1		1	ACPT	19	51293713	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	128468	51293713	7835270	927	29403										
SIGLEC8	27181	broad.mit.edu	37	chr19	51958762	51958762	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggtgaattccccttcatcccTcacgtgcactcgaggcagct	9	15	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:51958762T>C	uc002pwt.2	-	4	1028	c.961A>G	c.(961-963)AGG>GGG	p.R321G	SIGLEC8_uc010yda.1_Missense_Mutation_p.R212G|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.R228G	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	321	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CCTTCATCCCTCACGTGCACT	0.642													0	0	0	0.001168	0	6	41										C	51958762	T	C	51958762	3	2	96	1	0	0	0	0	1	0	0	0	14314	1550	54	5	554	5	SIGLEC8	19	51958762	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	665049	51958762	7170221	928	29404										
FPR2	2358	broad.mit.edu	37	chr19	52272587	52272587	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tctgctatgggctcattgcaGccaagatccacaaaaagggc	10	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:52272587G>T	uc002pxr.2	+	2	721	c.676G>T	c.(676-678)GCC>TCC	p.A226S	FPR2_uc002pxs.3_Missense_Mutation_p.A226S|FPR2_uc010epf.2_Missense_Mutation_p.A226S	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	226	Helical; Name=5; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						GCTCATTGCAGCCAAGATCCA	0.498													1	0	4.67007e-22	0.00874	5.94597e-22	42	58										T	52272587	G	T	52272587	3	4	96	1	0	0	0	0	1	0	0	0	6039	971	34	4	678	4	FPR2	19	52272587	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	313825	52272587	6856396	929	29405										
PPP2R1A	5518	broad.mit.edu	37	chr19	52719275	52719275	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagttctgtgaaaacctctCagctgactgtcgggagaatg	12	8	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:52719275C>T	uc002pyp.2	+	8	1100	c.941C>T	c.(940-942)TCA>TTA	p.S314L	PPP2R1A_uc010ydk.1_Missense_Mutation_p.S259L|PPP2R1A_uc010epm.1_Missense_Mutation_p.S354L|PPP2R1A_uc002pyq.2_Missense_Mutation_p.S135L	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	314	PP2A subunit B binding.|HEAT 8.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GAAAACCTCTCAGCTGACTGT	0.547			Mis		clear cell ovarian carcinoma								0	0	0	0.002222	0	43	51										T	52719275	C	T	52719275	3	4	96	1	0	0	0	0	1	0	0	0	12382	838	29	1	971	1	PPP2R1A	19	52719275	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	446688	52719275	6409708	930	29406										
ZNF845	91664	broad.mit.edu	37	chr19	53856074	53856074	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaaggcaattcatactggaGagaaaccttacaagtgtaat	8	7	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:53856074G>C	uc010ydv.1	+	4	2263	c.2146G>C	c.(2146-2148)GAG>CAG	p.E716Q	ZNF845_uc010ydw.1_Missense_Mutation_p.E716Q	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	716				Missing (in Ref. 1; BAG58121).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATACTGGAGAGAAACCTTA	0.418													0	0	0	0.004289	0	37	118										C	53856074	G	C	53856074	3	2	96	1	0	0	0	0	1	0	0	0	18188	943	33	1	2156	1	ZNF845	19	53856074	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1136799	53856074	5272909	931	29407										
CACNG6	59285	broad.mit.edu	37	chr19	54496189	54496189	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggcggcggggggccgcgggcCggcggcgggcgcacgggcag	26	13	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:54496189C>T	uc002qct.2	+	1	648	c.58C>T	c.(58-60)CGG>TGG	p.R20W	CACNG6_uc002qcu.2_Missense_Mutation_p.R20W|CACNG6_uc002qcv.2_Missense_Mutation_p.R20W	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	20						voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		ggccgcgggccggcggcgggc	0.572													0	0	0	0.000248	0	4	31										T	54496189	C	T	54496189	3	4	96	1	0	0	0	0	1	0	0	0	2561	643	23	2	60	2	CACNG6	19	54496189	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	640115	54496189	4632794	932	29408										
TTYH1	57348	broad.mit.edu	37	chr19	54933464	54933464	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggagctggtggctgccgcccGaggggctcgacggcaggcgg	21	12	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:54933464G>C	uc002qfq.2	+	4	610	c.518G>C	c.(517-519)CGA>CCA	p.R173P	TTYH1_uc010yey.1_Missense_Mutation_p.R222P|TTYH1_uc002qfr.2_Missense_Mutation_p.R173P|TTYH1_uc002qft.2_Missense_Mutation_p.R173P|TTYH1_uc002qfu.1_Missense_Mutation_p.R85P	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	173	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GCTGCCGCCCGAGGGGCTCGA	0.711													0	0	0	0.000248	0	4	9										C	54933464	G	C	54933464	3	2	96	1	0	0	0	0	1	0	0	0	16736	1058	37	1	532	1	TTYH1	19	54933464	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	437275	54933464	4195519	933	29409										
NCR1	9437	broad.mit.edu	37	chr19	55420603	55420603	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tggccccaccttctctcataGaaatgtatgacacacccacc	5	16	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:55420603G>A	uc002qib.2	+	4	394	c.356_splice	c.e4-1	p.E119_splice	NCR1_uc002qic.2_Splice_Site_p.E119_splice|NCR1_uc002qie.2_Splice_Site_p.E119_splice|NCR1_uc002qid.2_Splice_Site_p.Q24_splice|NCR1_uc002qif.2_Splice_Site_p.Q24_splice|NCR1_uc010esj.2_Splice_Site_p.E12_splice	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1						cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		TTCTCTCATAGAAATGTATGA	0.408													0	0	0	0.001168	0	5	65										A	55420603	G	A	55420603	5	1	96	1	0	0	0	0	0	0	1	0	10237	956	33	1	369	1	NCR1	19	55420603	Splice_Site	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	487139	55420603	3708380	934	29410										
RDH13	112724	broad.mit.edu	37	chr19	55570559	55570559	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tccaaggcggtctgcttcccGatgcctgtgttggcacccgt	12	14	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:55570559G>A	uc002qio.3	-	2	335	c.150C>T	c.(148-150)ATC>ATT	p.I50I	RDH13_uc002qip.2_5'UTR|RDH13_uc010yfq.1_Intron	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	50	NAD or NADP (By similarity).						binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	TCTGCTTCCCGATGCCTGTGT	0.483													0	0	0	0.006214	0	10	8										A	55570559	G	A	55570559	2	1	96	1	0	0	0	0	0	0	0	1	13192	1048	37	1		1	RDH13	19	55570559	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	149956	55570559	3558424	935	29411										
ZNF471	57573	broad.mit.edu	37	chr19	57036421	57036421	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatgtggcaaagccttcagtGatggctcgtcttttgctcga	11	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:57036421G>A	uc002qnh.2	+	5	1118	c.985G>A	c.(985-987)GAT>AAT	p.D329N		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	329	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		AGCCTTCAGTGATGGCTCGTC	0.433													0	0	0	0.003954	0	21	91										A	57036421	G	A	57036421	3	1	96	1	0	0	0	0	1	0	0	0	17927	1290	45	1	999	1	ZNF471	19	57036421	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1465862	57036421	2092562	936	29412										
ZNF549	256051	broad.mit.edu	37	chr19	58049333	58049333	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gctccaaatactcacttgtgGaacaccagagaacccataat	6	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58049333G>A	uc002qpb.1	+	4	1210	c.961G>A	c.(961-963)GAA>AAA	p.E321K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.E308K	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	321	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCACTTGTGGAACACCAGAG	0.438													0	0	0	0.001523	0	21	90										A	58049333	G	A	58049333	3	1	96	1	0	0	0	0	1	0	0	0	17978	1175	41	1	932	1	ZNF549	19	58049333	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1012912	58049333	1079650	937	29413										
ZSCAN1	284312	broad.mit.edu	37	chr19	58551908	58551908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaggtcccagaaagaaccatCgcaggtgagcccggggcccc	13	14	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58551908C>T	uc002qrc.1	+	4	708	c.461C>T	c.(460-462)TCG>TTG	p.S154L		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	154					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AAAGAACCATCGCAGGTGAGC	0.627													0	0	0	0.006214	0	9	172										T	58551908	C	T	58551908	3	4	96	1	0	0	0	0	1	0	0	0	18223	893	31	1	467	1	ZSCAN1	19	58551908	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	502575	58551908	577075	938	29414										
ZSCAN22	342945	broad.mit.edu	37	chr19	58850581	58850581	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcctccctcattgagcaccaGaggatccacacgggagagaa	10	13	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58850581G>C	uc002qsc.2	+	3	1512	c.1365G>C	c.(1363-1365)CAG>CAC	p.Q455H	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	455	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		TTGAGCACCAGAGGATCCACA	0.542													0	0	0	0.001855	0	14	116										C	58850581	G	C	58850581	3	2	96	1	0	0	0	0	1	0	0	0	18231	933	33	1	1371	1	ZSCAN22	19	58850581	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	298673	58850581	278402	939	29415										
ZSCAN22	342945	broad.mit.edu	37	chr19	58850597	58850597	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	accagaggatccacacgggaGagaagccttataagtgcagc	12	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:58850597G>C	uc002qsc.2	+	3	1528	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	461					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		CCACACGGGAGAGAAGCCTTA	0.542													0	0	0	0.004482	0	8	110										C	58850597	G	C	58850597	3	2	96	1	0	0	0	0	1	0	0	0	18231	943	33	1	1387	1	ZSCAN22	19	58850597	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	16	58850597	278386	940	29416										
ZBTB45	84878	broad.mit.edu	37	chr19	59025544	59025544	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atgtgcacgttgagcgagctCttctgcgtgaagcgcttggc	14	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr19:59025544C>T	uc002qtd.2	-	3	1705	c.1413G>A	c.(1411-1413)AAG>AAA	p.K471K	SLC27A5_uc002qtc.2_5'Flank|ZBTB45_uc002qte.2_Silent_p.K471K|ZBTB45_uc002qtf.2_Silent_p.K471K	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	471	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		TGAGCGAGCTCTTCTGCGTGA	0.682													0	0	0	0.001984	0	6	30										T	59025544	C	T	59025544	2	4	96	1	0	0	0	0	0	0	0	1	17543	912	32	1		1	ZBTB45	19	59025544	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	174947	59025544	103439	941	29417										
ANGPT4	51378	broad.mit.edu	37	chr20	854974	854974	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agagacagtggtcgttgtctGagtcaagggtgctaaagctg	15	6	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:854974G>C	uc002wei.2	-	8	1407	c.1304C>G	c.(1303-1305)TCA>TGA	p.S435*	ANGPT4_uc010zpn.1_Intron	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	435	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GTCGTTGTCTGAGTCAAGGGT	0.612													0	0	0	0.005443	0	26	90										C	854974	G	C	854974	4	2	96	1	0	0	0	0	0	1	0	0	612	1294	45	1	215	1	ANGPT4	20	854974	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		854974	62170546	942	29418										
NSFL1C	55968	broad.mit.edu	37	chr20	1447415	1447415	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagcgggcccggtcctcctCggcgcccgtcaccgccacga	13	19	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:1447415C>A	uc002wfc.2	-	1	1003	c.55G>T	c.(55-57)GAG>TAG	p.E19*	NSFL1C_uc002wfd.2_5'UTR|NSFL1C_uc002wfe.2_Nonsense_Mutation_p.E19*|NSFL1C_uc002wff.2_RNA	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a	19						chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						CGGTCCTCCTCGGCGCCCGTC	0.746													1	0	0.00024832	0.000248	0.000295521	3	8										A	1447415	C	A	1447415	4	1	96	1	0	0	0	0	0	1	0	0	10672	893	31	3	1093	3	NSFL1C	20	1447415	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	592441	1447415	61578105	943	29419										
CPXM1	56265	broad.mit.edu	37	chr20	2776510	2776510	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaaaggggatccgcttcatCcacttgattactgcccgcgt	9	13	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:2776510C>A	uc002wgu.2	-	11	1519	c.1455G>T	c.(1453-1455)TGG>TGT	p.W485C	CPXM1_uc010gas.2_Missense_Mutation_p.W485C	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	485					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						TCCGCTTCATCCACTTGATTA	0.637													1	0	1.96292e-10	0.001523	2.43673e-10	21	70										A	2776510	C	A	2776510	3	1	96	1	0	0	0	0	1	0	0	0	3837	856	30	3	765	3	CPXM1	20	2776510	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1329095	2776510	60249010	944	29420										
ZNF133	7692	broad.mit.edu	37	chr20	18286394	18286394	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggaggctgctgagccctgctCaaaggactctgtacagagag	14	10	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:18286394C>T	uc010gcq.2	+	3	369	c.64C>T	c.(64-66)CAA>TAA	p.Q22*	ZNF133_uc010zrv.1_Nonsense_Mutation_p.Q25*|ZNF133_uc010zrw.1_5'UTR|ZNF133_uc010gcr.2_Nonsense_Mutation_p.Q22*|ZNF133_uc010zrx.1_Intron|ZNF133_uc002wql.3_Nonsense_Mutation_p.Q22*|ZNF133_uc010gcs.2_Nonsense_Mutation_p.Q22*|ZNF133_uc010zry.1_Intron|ZNF133_uc002wqm.2_Nonsense_Mutation_p.Q22*	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	22	KRAB.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GAGCCCTGCTCAAAGGACTCT	0.512													0	0	0	0.002096	0	30	69										T	18286394	C	T	18286394	4	4	96	1	0	0	0	0	0	1	0	0	17720	827	29	1	66	1	ZNF133	20	18286394	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	15509884	18286394	44739126	945	29421										
C20orf26	26074	broad.mit.edu	37	chr20	20177312	20177312	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacatgcatcactttgccctCaaccccattttccggcacta	4	17	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:20177312C>G	uc002wru.2	+	16	1765	c.1689C>G	c.(1687-1689)CTC>CTG	p.L563L	C20orf26_uc010zse.1_Silent_p.L543L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	563										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ACTTTGCCCTCAACCCCATTT	0.463													0	0	0	0.002836	0	34	97										G	20177312	C	G	20177312	2	3	96	1	0	0	0	0	0	0	0	1	2106	813	29	1		1	C20orf26	20	20177312	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1890918	20177312	42848208	946	29422										
THBD	7056	broad.mit.edu	37	chr20	23028421	23028421	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggacggaggccgctcagagtCtctgcggcgtccgctcggtc	16	14	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:23028421C>T	uc002wss.2	-	1	1881	c.1721G>A	c.(1720-1722)AGA>AAA	p.R574K	THBD_uc002wst.1_RNA	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	574	Cytoplasmic (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	CGCTCAGAGTCTCTGCGGCGT	0.647													0	0	0	0.001168	0	6	8										T	23028421	C	T	23028421	3	4	96	1	0	0	0	0	1	0	0	0	15849	913	32	1	10	1	THBD	20	23028421	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2851109	23028421	39997099	947	29423										
NCOA6	23054	broad.mit.edu	37	chr20	33370146	33370146	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtcttctaagtttggaaggtCatccaaaaccatggtgaata	9	7	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33370146C>G	uc002xav.2	-	4	2584	c.13G>C	c.(13-15)GAC>CAC	p.D5H	NCOA6_uc002xaw.2_Missense_Mutation_p.D5H|NCOA6_uc010gew.1_Missense_Mutation_p.D5H	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	5	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TTTGGAAGGTCATCCAAAACC	0.368													0	0	0	0.001855	0	14	47										G	33370146	C	G	33370146	3	3	96	1	0	0	0	0	1	0	0	0	10233	826	29	1	6230	1	NCOA6	20	33370146	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	10341725	33370146	29655374	948	29424										
PROCR	10544	broad.mit.edu	37	chr20	33762609	33762609	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacacctaacgcacgtgctgGaaggcccagacaccaacacc	9	16	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33762609G>A	uc002xbt.2	+	2	359	c.175G>A	c.(175-177)GAA>AAA	p.E59K	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Missense_Mutation_p.E96K	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	59	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	GCACGTGCTGGAAGGCCCAGA	0.617													0	0	0	0.005443	0	27	75										A	33762609	G	A	33762609	3	1	96	1	0	0	0	0	1	0	0	0	12547	1175	41	1	181	1	PROCR	20	33762609	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	392463	33762609	29262911	949	29425										
PROCR	10544	broad.mit.edu	37	chr20	33762683	33762683	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagagctgggcgcgcacgcaGagtggcctgcagtcctacct	15	13	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33762683G>C	uc002xbt.2	+	2	433	c.249G>C	c.(247-249)CAG>CAC	p.Q83H	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Missense_Mutation_p.Q120H	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	83	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	CGCGCACGCAGAGTGGCCTGC	0.637													0	0	0	0.004482	0	9	14										C	33762683	G	C	33762683	3	2	96	1	0	0	0	0	1	0	0	0	12547	933	33	1	255	1	PROCR	20	33762683	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	74	33762683	29262837	950	29426										
PROCR	10544	broad.mit.edu	37	chr20	33764071	33764071	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgaatgggagctcctttgtGagtttccggccggagagagc	16	8	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33764071G>A	uc002xbt.2	+	3	607	c.423G>A	c.(421-423)GTG>GTA	p.V141V	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Silent_p.V178V	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	141	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	GCTCCTTTGTGAGTTTCCGGC	0.602													0	0	0	0.00874	0	39	120										A	33764071	G	A	33764071	2	1	96	1	0	0	0	0	0	0	0	1	12547	1277	45	1		1	PROCR	20	33764071	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1388	33764071	29261449	951	29427										
UQCC	55245	broad.mit.edu	37	chr20	33891806	33891806	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctgaggattcttctccactaGagggcgccagctcacctccc	9	16	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:33891806G>A	uc002xcd.2	-	10	899	c.832C>T	c.(832-834)CTA>TTA	p.L278L	UQCC_uc010zuy.1_Silent_p.L179L|UQCC_uc010zuz.1_Silent_p.L123L|UQCC_uc010zva.1_Silent_p.L141L|UQCC_uc002xce.2_Silent_p.L251L|UQCC_uc002xcg.2_Silent_p.L144L|UQCC_uc010gfb.2_Silent_p.L252L|UQCC_uc010zvb.1_Silent_p.L210L|UQCC_uc002xcf.2_Silent_p.L166L|UQCC_uc002xch.2_RNA|UQCC_uc002xcc.2_Silent_p.L91L	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform	278						cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TTCTCCACTAGAGGGCGCCAG	0.607											OREG0025888	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	43	96										A	33891806	G	A	33891806	2	1	96	1	0	0	0	0	0	0	0	1	17012	933	33	1		1	UQCC	20	33891806	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	127735	33891806	29133714	952	29428										
CPNE1	8904	broad.mit.edu	37	chr20	34214245	34214245	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aaccctgggccctgaagtatGagaccagttgtgtgggcact	13	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:34214245G>A	uc002xdf.2	-	18	1895	c.1532C>T	c.(1531-1533)TCA>TTA	p.S511L	CPNE1_uc002xdc.2_Missense_Mutation_p.S173L|CPNE1_uc010zvj.1_Missense_Mutation_p.S516L|CPNE1_uc002xde.2_Missense_Mutation_p.S487L|CPNE1_uc002xdg.2_Missense_Mutation_p.S455L|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.S511L|CPNE1_uc002xdi.2_Missense_Mutation_p.S511L|CPNE1_uc002xdj.2_Missense_Mutation_p.S511L|CPNE1_uc002xdk.2_Missense_Mutation_p.S511L|CPNE1_uc002xdl.2_Missense_Mutation_p.S511L|CPNE1_uc002xdm.2_Missense_Mutation_p.S511L	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	511					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CCTGAAGTATGAGACCAGTTG	0.622													0	0	0	0.002852	0	43	141										A	34214245	G	A	34214245	3	1	96	1	0	0	0	0	1	0	0	0	3811	1294	45	1	85	1	CPNE1	20	34214245	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	322439	34214245	28811275	953	29429										
EPB41L1	2036	broad.mit.edu	37	chr20	34776319	34776319	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtttgtgccaatggcctgctCatctaccgggaccggctgag	13	12	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:34776319C>T	uc002xfb.2	+	9	1095	c.924C>T	c.(922-924)CTC>CTT	p.L308L	EPB41L1_uc002xeu.2_Silent_p.L246L|EPB41L1_uc010zvo.1_Silent_p.L308L|EPB41L1_uc002xev.2_Silent_p.L308L|EPB41L1_uc002xew.2_Silent_p.L211L|EPB41L1_uc002xex.2_Silent_p.L277L|EPB41L1_uc002xey.2_Silent_p.L235L|EPB41L1_uc002xez.2_Silent_p.L246L	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	308	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					ATGGCCTGCTCATCTACCGGG	0.562													0	0	0	0.005443	0	27	100										T	34776319	C	T	34776319	2	4	96	1	0	0	0	0	0	0	0	1	5152	813	29	1		1	EPB41L1	20	34776319	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	562074	34776319	28249201	954	29430										
CTNNBL1	56259	broad.mit.edu	37	chr20	36431360	36431360	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaactgccataagtttgttGacattcttggcttacgaacc	7	10	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:36431360G>C	uc010zvw.1	+	12	1214	c.1123G>C	c.(1123-1125)GAC>CAC	p.D375H	CTNNBL1_uc002xhh.2_Missense_Mutation_p.D188H|CTNNBL1_uc002xhi.2_RNA|CTNNBL1_uc002xhj.2_Missense_Mutation_p.D123H	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	375					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				TAAGTTTGTTGACATTCTTGG	0.483													0	0	0	0.003954	0	25	81										C	36431360	G	C	36431360	3	2	96	1	0	0	0	0	1	0	0	0	4018	1290	45	1	1165	1	CTNNBL1	20	36431360	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1655041	36431360	26594160	955	29431										
DHX35	60625	broad.mit.edu	37	chr20	37662928	37662928	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgaatcggcctggctgttgGagctggctccacacttttat	11	10	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:37662928G>C	uc002xjh.2	+	21	2046	c.2035G>C	c.(2035-2037)GAG>CAG	p.E679Q	DHX35_uc010zwa.1_Missense_Mutation_p.E524Q|DHX35_uc010zwb.1_Missense_Mutation_p.E524Q|DHX35_uc010zwc.1_Missense_Mutation_p.E648Q	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	679						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CTGGCTGTTGGAGCTGGCTCC	0.448													0	0	0	0.005524	0	33	78										C	37662928	G	C	37662928	3	2	96	1	0	0	0	0	1	0	0	0	4508	1175	41	1	2117	1	DHX35	20	37662928	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1231568	37662928	25362592	956	29432										
DHX35	60625	broad.mit.edu	37	chr20	37662949	37662949	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agctggctccacacttttatCaacaaggaacggtaggaatg	10	9	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:37662949C>G	uc002xjh.2	+	21	2067	c.2056C>G	c.(2056-2058)CAA>GAA	p.Q686E	DHX35_uc010zwa.1_Missense_Mutation_p.Q531E|DHX35_uc010zwb.1_Missense_Mutation_p.Q531E|DHX35_uc010zwc.1_Missense_Mutation_p.Q655E	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	686						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				ACACTTTTATCAACAAGGAAC	0.448													0	0	0	0.005443	0	25	74										G	37662949	C	G	37662949	3	3	96	1	0	0	0	0	1	0	0	0	4508	827	29	1	2138	1	DHX35	20	37662949	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	21	37662949	25362571	957	29433										
ZHX3	23051	broad.mit.edu	37	chr20	39832342	39832342	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cctggaagagcggcctggatGagatgctggacattgccagc	15	10	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:39832342G>A	uc002xjs.1	-	3	1593	c.1215C>T	c.(1213-1215)CTC>CTT	p.L405L	ZHX3_uc002xjq.1_Intron|ZHX3_uc002xjr.1_Silent_p.L405L|ZHX3_uc002xjt.1_Silent_p.L405L|ZHX3_uc002xju.1_Silent_p.L405L|ZHX3_uc002xjv.1_Silent_p.L405L|ZHX3_uc002xjw.1_Silent_p.L405L|ZHX3_uc010ggg.1_Silent_p.L405L	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	405	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				CGGCCTGGATGAGATGCTGGA	0.542													0	0	0	0.003954	0	24	100										A	39832342	G	A	39832342	2	1	96	1	0	0	0	0	0	0	0	1	17674	1277	45	1		1	ZHX3	20	39832342	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2169393	39832342	23193178	958	29434										
C20orf111	51526	broad.mit.edu	37	chr20	42825868	42825868	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cagcgactgagagtagtcctCaagtgtggatcttcgttctg	12	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:42825868C>G	uc002xlk.2	-	4	840	c.703G>C	c.(703-705)GAG>CAG	p.E235Q		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	235											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GAGTAGTCCTCAAGTGTGGAT	0.522													0	0	0	0.006214	0	10	60										G	42825868	C	G	42825868	3	3	96	1	0	0	0	0	1	0	0	0	2080	835	29	1	179	1	C20orf111	20	42825868	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2993526	42825868	20199652	959	29435										
MMP9	4318	broad.mit.edu	37	chr20	44642135	44642135	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgaacatcttcgacgccatCgcggagattgggaaccagct	12	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:44642135C>A	uc002xqz.2	+	9	1591	c.1572C>A	c.(1570-1572)ATC>ATA	p.I524I		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	524	Hemopexin-like 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TCGACGCCATCGCGGAGATTG	0.507											OREG0025990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	4.3838e-07	0.001855	5.30031e-07	12	19										A	44642135	C	A	44642135	2	1	96	1	0	0	0	0	0	0	0	1	9669	874	31	3		3	MMP9	20	44642135	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1816267	44642135	18383385	960	29436										
ZMYND8	23613	broad.mit.edu	37	chr20	45850058	45850058	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gattgtgtgctcgaggagctCccctgggaggacttatttag	14	8	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:45850058C>A	uc002xta.1	-	20	3518	c.3264G>T	c.(3262-3264)GGG>GGT	p.G1088G	ZMYND8_uc010ghq.1_Silent_p.G719G|ZMYND8_uc010ghr.1_Silent_p.G990G|ZMYND8_uc002xst.1_Silent_p.G970G|ZMYND8_uc002xsu.1_Silent_p.G961G|ZMYND8_uc002xsv.1_Silent_p.G1016G|ZMYND8_uc002xsw.1_Silent_p.G794G|ZMYND8_uc002xsx.1_Silent_p.G794G|ZMYND8_uc002xsy.1_Silent_p.G1017G|ZMYND8_uc002xsz.1_Silent_p.G979G|ZMYND8_uc010zxy.1_Silent_p.G1115G|ZMYND8_uc002xtb.1_Silent_p.G1062G|ZMYND8_uc002xss.2_Silent_p.G1088G|ZMYND8_uc010zxz.1_Silent_p.G956G|ZMYND8_uc002xtc.1_Silent_p.G1062G|ZMYND8_uc002xtd.1_Silent_p.G1037G|ZMYND8_uc002xte.1_Silent_p.G1042G|ZMYND8_uc010zya.1_Silent_p.G1088G|ZMYND8_uc002xtf.1_Silent_p.G1108G|ZMYND8_uc002xsr.1_Silent_p.G187G	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1088							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCGAGGAGCTCCCCTGGGAGG	0.547													1	0	3.6726e-16	0.003954	4.62286e-16	27	43										A	45850058	C	A	45850058	2	1	96	1	0	0	0	0	0	0	0	1	17708	842	30	3		3	ZMYND8	20	45850058	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1207923	45850058	17175462	961	29437										
NFATC2	4773	broad.mit.edu	37	chr20	50140246	50140246	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggggagaaggtgtcagaaatGaagctggcagaggagccgct	18	6	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:50140246G>T	uc002xwd.2	-	2	754	c.534C>A	c.(532-534)TTC>TTA	p.F178L	NFATC2_uc002xwc.2_Missense_Mutation_p.F178L|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Missense_Mutation_p.F158L|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Missense_Mutation_p.F158L	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	178	Trans-activation domain A (TAD-A).				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					TGTCAGAAATGAAGCTGGCAG	0.647													1	0	6.94344e-10	0.006122	8.58245e-10	18	57										T	50140246	G	T	50140246	3	4	96	1	0	0	0	0	1	0	0	0	10362	1281	45	3	2327	3	NFATC2	20	50140246	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4290188	50140246	12885274	962	29438										
C20orf85	128602	broad.mit.edu	37	chr20	56728648	56728648	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gcacggcagaactggccccaGaactgggggtttttaacaac	12	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:56728648G>C	uc002xyv.2	+	2	155	c.117G>C	c.(115-117)CAG>CAC	p.Q39H		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	39										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			ACTGGCCCCAGAACTGGGGGT	0.433													0	0	0	0.007291	0	28	91										C	56728648	G	C	56728648	3	2	96	1	0	0	0	0	1	0	0	0	2120	933	33	1	123	1	C20orf85	20	56728648	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6588402	56728648	6296872	963	29439										
NPEPL1	79716	broad.mit.edu	37	chr20	57268911	57268911	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gagccggcacaacagcccctCggccgcccacttcatcacgc	9	20	2	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:57268911C>T	uc010zzs.1	+	2	364	c.269C>T	c.(268-270)TCG>TTG	p.S90L	NPEPL1_uc010zzr.1_Missense_Mutation_p.S42L|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.S62L|NPEPL1_uc002xzp.2_5'UTR	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	90					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			AACAGCCCCTCGGCCGCCCAC	0.682													0	0	0	0.008291	0	10	47										T	57268911	C	T	57268911	3	4	96	1	0	0	0	0	1	0	0	0	10574	893	31	1	121	1	NPEPL1	20	57268911	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	540263	57268911	5756609	964	29440										
DIDO1	11083	broad.mit.edu	37	chr20	61526493	61526493	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tttcgccaaagagatttcctCacgcagaacacgatggaaga	9	10	1	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:61526493C>G	uc002ydr.1	-	9	2503	c.2239G>C	c.(2239-2241)GAG>CAG	p.E747Q	DIDO1_uc002yds.1_Missense_Mutation_p.E747Q|DIDO1_uc002ydt.1_Missense_Mutation_p.E747Q|DIDO1_uc002ydu.1_Missense_Mutation_p.E747Q	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	747	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GAGATTTCCTCACGCAGAACA	0.413													0	0	0	0.00361	0	66	191										G	61526493	C	G	61526493	3	3	96	1	0	0	0	0	1	0	0	0	4522	835	29	1	4544	1	DIDO1	20	61526493	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	4257582	61526493	1499027	965	29441										
PRIC285	85441	broad.mit.edu	37	chr20	62198551	62198551	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcctgctggtagcacaggaaGaggcggtgcagcagcgtgtg	17	9	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62198551G>C	uc002yfm.2	-	7	3052	c.2160C>G	c.(2158-2160)CTC>CTG	p.L720L	PRIC285_uc002yfl.1_Silent_p.L151L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	720					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			AGCACAGGAAGAGGCGGTGCA	0.677													0	0	0	0.001368	0	12	49										C	62198551	G	C	62198551	2	2	96	1	0	0	0	0	0	0	0	1	12485	929	33	1		1	PRIC285	20	62198551	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	672058	62198551	826969	966	29442			3	130		3	3	363	G		6.833203e-05
PRIC285	85441	broad.mit.edu	37	chr20	62198716	62198716	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	atctgggccgcctcatcgatGagaatgtgggagaagaagcc	14	9	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62198716G>C	uc002yfm.2	-	7	2887	c.1995C>G	c.(1993-1995)CTC>CTG	p.L665L	PRIC285_uc002yfl.1_Silent_p.L96L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	665					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCTCATCGATGAGAATGTGGG	0.706													0	0	0	0.004672	0	3	7										C	62198716	G	C	62198716	2	2	96	1	0	0	0	0	0	0	0	1	12485	1277	45	1		1	PRIC285	20	62198716	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	165	62198716	826804	967	29443			3	130		3	3	363	G		6.833203e-05
PRIC285	85441	broad.mit.edu	37	chr20	62198913	62198913	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cgtgtacatcacacggagagGagtggcctcggggtggccgc	17	11	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62198913G>C	uc002yfm.2	-	7	2690	c.1798C>G	c.(1798-1800)CCT>GCT	p.P600A	PRIC285_uc002yfl.1_Missense_Mutation_p.P31A	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	600					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			ACACGGAGAGGAGTGGCCTCG	0.667													0	0	0	0.000602	0	4	8										C	62198913	G	C	62198913	3	2	96	1	0	0	0	0	1	0	0	0	12485	1174	41	1	6207	1	PRIC285	20	62198913	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	197	62198913	826607	968	29444			3	130		3	3	363	G		6.833203e-05
TNFRSF6B	8771	broad.mit.edu	37	chr20	62329778	62329778	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ggccgcgcggccttgcagctGaagctgcgtcggcggctcac	16	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62329778G>A	uc002yfy.2	+	7	1199	c.765G>A	c.(763-765)CTG>CTA	p.L255L	RTEL1_uc002yfw.2_RNA|TNFRSF6B_uc002yfz.2_Silent_p.L255L	NM_032945	NP_116563	O95407	TNF6B_HUMAN	tumor necrosis factor receptor superfamily,	255					anti-apoptosis|apoptosis	extracellular region|soluble fraction	protein binding|receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.66e-12)|all_epithelial(29;2.56e-13)|Lung NSC(23;1.06e-08)|all_lung(23;3.34e-08)		Epithelial(9;1.78e-08)|all cancers(9;7.89e-08)|OV - Ovarian serous cystadenocarcinoma(5;0.00504)			CCTTGCAGCTGAAGCTGCGTC	0.746													0	0	0	0.006214	0	9	14										A	62329778	G	A	62329778	2	1	96	1	0	0	0	0	0	0	0	1	16295	1277	45	1		1	TNFRSF6B	20	62329778	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	130865	62329778	695742	969	29445										
ARFRP1	10139	broad.mit.edu	37	chr20	62331869	62331869	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caccatccactcgatgccctCgcgcacccctttgctgtgaa	7	18	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr20:62331869C>T	uc002yga.2	-	7	1099	c.532G>A	c.(532-534)GAG>AAG	p.E178K	ARFRP1_uc002ygc.2_Missense_Mutation_p.E178K|ARFRP1_uc002ygh.3_3'UTR|ARFRP1_uc011abf.1_3'UTR|ARFRP1_uc011abg.1_3'UTR|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.E178K|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	178					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			TCGATGCCCTCGCGCACCCCT	0.701													0	0	0	0.006122	0	18	55										T	62331869	C	T	62331869	3	4	96	1	0	0	0	0	1	0	0	0	856	893	31	1	77	1	ARFRP1	20	62331869	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2091	62331869	693651	970	29446										
NCAM2	4685	broad.mit.edu	37	chr21	22658708	22658708	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcagctggttgtatcataatGaggaagtcaccactatttcc	8	9	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:22658708G>A	uc002yld.1	+	4	706	c.457G>A	c.(457-459)GAG>AAG	p.E153K	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.E178K	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	153	Ig-like C2-type 2.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GTATCATAATGAGGAAGTCAC	0.388													0	0	0	0.000978	0	9	63										A	22658708	G	A	22658708	3	1	96	1	0	0	0	0	1	0	0	0	10203	1291	45	1	471	1	NCAM2	21	22658708	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08		22658708	25471187	971	29447										
GRIK1	2897	broad.mit.edu	37	chr21	30927614	30927614	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caatagtaattttatcccggTaaggagaacctggaagtaaa	9	6	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:30927614T>C	uc002yno.1	-	16	2830	c.2366A>G	c.(2365-2367)TAC>TGC	p.Y789C	GRIK1_uc002ynn.2_Missense_Mutation_p.Y774C|GRIK1_uc011acs.1_Missense_Mutation_p.Y789C|GRIK1_uc011act.1_Missense_Mutation_p.Y650C	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	789	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TTTATCCCGGTAAGGAGAACC	0.403													0	0	0	0.006122	0	18	93										C	30927614	T	C	30927614	3	2	96	1	0	0	0	0	1	0	0	0	6773	1638	57	5	558	5	GRIK1	21	30927614	Missense_Mutation	SNP	T	TCGA-G2-A2EO-01A-11D-A17V-08	8268906	30927614	17202281	972	29448										
TCP10L	140290	broad.mit.edu	37	chr21	33956596	33956596	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctctttggggtccctggcctCgagttgacctgccagcatcc	11	15	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:33956596C>G	uc002ypw.3	-	2	135	c.19G>C	c.(19-21)GAG>CAG	p.E7Q	C21orf59_uc002ypx.1_Intron|C21orf59_uc002ypy.1_Intron|C21orf59_uc002ypz.1_Intron	NM_144659	NP_653260	Q9NV44	CU077_HUMAN	T-complex 10A-2	Error:Variant_position_missing_in_Q9NV44_after_alignment											0						TCCCTGGCCTCGAGTTGACCT	0.647													0	0	0	0.00245	0	14	36										G	33956596	C	G	33956596	3	3	96	1	0	0	0	0	1	0	0	0	15708	893	31	1	644	1	TCP10L	21	33956596	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3028982	33956596	14173299	973	29449										
ITSN1	6453	broad.mit.edu	37	chr21	35183344	35183344	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttaaaaggaaagacagggtgGttccctgcaaactatgcaga	11	7	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:35183344G>A	uc002yta.1	+	21	2653	c.2385G>A	c.(2383-2385)TGG>TGA	p.W795*	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Nonsense_Mutation_p.W790*|ITSN1_uc010gmg.2_Nonsense_Mutation_p.W753*|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Nonsense_Mutation_p.W795*|ITSN1_uc010gmi.2_Nonsense_Mutation_p.W758*|ITSN1_uc010gmj.2_Nonsense_Mutation_p.W674*|ITSN1_uc002ysy.2_Nonsense_Mutation_p.W790*|ITSN1_uc002ysx.2_Nonsense_Mutation_p.W753*|ITSN1_uc002ytb.1_Nonsense_Mutation_p.W790*|ITSN1_uc002ytc.1_Nonsense_Mutation_p.W790*|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Nonsense_Mutation_p.W758*|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Nonsense_Mutation_p.W790*|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Nonsense_Mutation_p.W729*|ITSN1_uc002ytf.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	795	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGACAGGGTGGTTCCCTGCAA	0.483													0	0	0	0.008871	0	21	150										A	35183344	G	A	35183344	4	1	96	1	0	0	0	0	0	1	0	0	7926	1270	44	2	2463	2	ITSN1	21	35183344	Nonsense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1226748	35183344	12946551	974	29450										
CLDN14	23562	broad.mit.edu	37	chr21	37833718	37833718	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acggcgcaggcgcaggctatGcccgagagcaggcaggagat	17	11	0	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:37833718G>A	uc002yvk.1	-	2	418	c.276C>T	c.(274-276)GGC>GGT	p.G92G	CLDN14_uc002yvn.1_Silent_p.G92G|CLDN14_uc002yvo.1_Silent_p.G92G|CLDN14_uc002yvl.1_Silent_p.G92G|CLDN14_uc002yvm.1_Silent_p.G92G	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	92	Helical; (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CGCAGGCTATGCCCGAGAGCA	0.662													0	0	0	0.004656	0	26	36										A	37833718	G	A	37833718	2	1	96	1	0	0	0	0	0	0	0	1	3475	1306	46	2		2	CLDN14	21	37833718	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2650374	37833718	10296177	975	29451										
RIPK4	54101	broad.mit.edu	37	chr21	43171292	43171292	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttggtgtcgaagagccggctCttctccctgatgcgctctgg	13	12	3	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:43171292C>G	uc002yzn.1	-	3	636	c.588G>C	c.(586-588)AAG>AAC	p.K196N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	196						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						AGAGCCGGCTCTTCTCCCTGA	0.602													0	0	0	0.001984	0	7	79										G	43171292	C	G	43171292	3	3	96	1	0	0	0	0	1	0	0	0	13383	912	32	1	1790	1	RIPK4	21	43171292	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5337574	43171292	4958603	976	29452										
TRPM2	7226	broad.mit.edu	37	chr21	45838307	45838307	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgtccgcccaccctgacagaGaacaagctggagaagaacga	11	12	0	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr21:45838307G>C	uc002zet.1	+	23	3543	c.3330G>C	c.(3328-3330)AAG>AAC	p.K1110N	TRPM2_uc002zeu.1_Missense_Mutation_p.K1110N|TRPM2_uc002zew.1_Missense_Mutation_p.K1110N|TRPM2_uc010gpt.1_Missense_Mutation_p.K1110N|TRPM2_uc002zex.1_Missense_Mutation_p.K896N|TRPM2_uc002zey.1_Missense_Mutation_p.K623N|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1110	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCCTGACAGAGAACAAGCTGG	0.642													0	0	0	0.00308	0	7	57										C	45838307	G	C	45838307	3	2	96	1	0	0	0	0	1	0	0	0	16583	956	33	1	3416	1	TRPM2	21	45838307	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2667015	45838307	2291588	977	29453										
CECR5	27440	broad.mit.edu	37	chr22	17624010	17624010	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcaatgcgggggaagtcattCctcgggaggggctgcagaga	17	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:17624010C>T	uc002zmf.2	-	5	577	c.549G>A	c.(547-549)AGG>AGA	p.R183R	CECR5_uc002zmd.2_5'Flank|CECR5_uc002zme.2_Intron|CECR5_uc002zmg.2_Silent_p.R46R|CECR5_uc002zmh.2_Silent_p.R153R	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	183							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)				GGAAGTCATTCCTCGGGAGGG	0.567													0	0	0	0.004007	0	16	52										T	17624010	C	T	17624010	2	4	96	1	0	0	0	0	0	0	0	1	3207	854	30	1		1	CECR5	22	17624010	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		17624010	33680556	978	29454										
CDC45	8318	broad.mit.edu	37	chr22	19495340	19495340	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggccatggacatctccttGaaggagaatttgcgggaaat	12	8	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:19495340G>C	uc002zpr.2	+	12	1084	c.1008G>C	c.(1006-1008)TTG>TTC	p.L336F	CDC45_uc011agz.1_Missense_Mutation_p.L331F|CDC45_uc011aha.1_Missense_Mutation_p.L368F|CDC45_uc002zps.2_Missense_Mutation_p.L336F|CDC45_uc002zpt.2_Missense_Mutation_p.L290F	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	336					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						ACATCTCCTTGAAGGAGAATT	0.443													0	0	0	0.00361	0	50	95										C	19495340	G	C	19495340	3	2	96	1	0	0	0	0	1	0	0	0	3081	1281	45	1	1154	1	CDC45	22	19495340	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1871330	19495340	31809226	979	29455										
RTN4R	65078	broad.mit.edu	37	chr22	20229926	20229926	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acgcaggggggccagggcctCagtgggcagcgctgatagat	18	10	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:20229926C>T	uc002zrv.2	-	2	931	c.730G>A	c.(730-732)GAG>AAG	p.E244K	RTN4R_uc002zru.2_Missense_Mutation_p.E16K	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	244	LRR 8.				axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					GCCAGGGCCTCAGTGGGCAGC	0.642													0	0	0	0.008871	0	19	32										T	20229926	C	T	20229926	3	4	96	1	0	0	0	0	1	0	0	0	13730	835	29	1	695	1	RTN4R	22	20229926	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	734586	20229926	31074640	980	29456										
SERPIND1	3053	broad.mit.edu	37	chr22	21138315	21138315	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cacaaccacaacttccggctGaatgagagagaggtagttaa	10	9	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:21138315G>A	uc002ztb.1	+	3	1012	c.945G>A	c.(943-945)CTG>CTA	p.L315L	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Silent_p.L343L	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	315					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	ACTTCCGGCTGAATGAGAGAG	0.493											OREG0026325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	86	184										A	21138315	G	A	21138315	2	1	96	1	0	0	0	0	0	0	0	1	14110	1277	45	1		1	SERPIND1	22	21138315	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	908389	21138315	30166251	981	29457										
MTMR3	8897	broad.mit.edu	37	chr22	30394779	30394779	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	taacttcaaggtttaaaaacGaggtggagaggatgggtttt	13	3	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:30394779G>C	uc003agv.3	+	8	818	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	MTMR3_uc003agu.3_Missense_Mutation_p.E164Q|MTMR3_uc003agw.3_Missense_Mutation_p.E164Q	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	164	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			GTTTAAAAACGAGGTGGAGAG	0.408													0	0	0	0.001168	0	6	21										C	30394779	G	C	30394779	3	2	96	1	0	0	0	0	1	0	0	0	9945	1059	37	1	512	1	MTMR3	22	30394779	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	9256464	30394779	20909787	982	29458										
TCN2	6948	broad.mit.edu	37	chr22	31011378	31011378	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acggatcaccatggccatcaGaacagtgcgagaggagatct	12	10	3	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:31011378G>C	uc003aip.1	+	5	829	c.671G>C	c.(670-672)AGA>ACA	p.R224T	TCN2_uc003aiq.1_Missense_Mutation_p.R220T|TCN2_uc003air.1_Missense_Mutation_p.R197T	NM_000355	NP_000346	P20062	TCO2_HUMAN	transcobalamin II precursor	224					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGGCCATCAGAACAGTGCGA	0.562													0	0	0	0.003271	0	34	78										C	31011378	G	C	31011378	3	2	96	1	0	0	0	0	1	0	0	0	15704	942	33	1	689	1	TCN2	22	31011378	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	616599	31011378	20293188	983	29459										
DEPDC5	9681	broad.mit.edu	37	chr22	32188758	32188758	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tcctgaaataaaccgagcctCaattcgacaggatcacaagg	8	11	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:32188758C>G	uc003als.2	+	12	864	c.722C>G	c.(721-723)TCA>TGA	p.S241*	DEPDC5_uc011als.1_Nonsense_Mutation_p.S241*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.S241*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.S241*|DEPDC5_uc003alr.1_Nonsense_Mutation_p.S241*|DEPDC5_uc011alt.1_Nonsense_Mutation_p.S213*	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	241					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						AACCGAGCCTCAATTCGACAG	0.363													0	0	0	0.005443	0	24	63										G	32188758	C	G	32188758	4	3	96	1	0	0	0	0	0	1	0	0	4442	838	29	1	764	1	DEPDC5	22	32188758	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1177380	32188758	19115808	984	29460										
SLC5A4	6527	broad.mit.edu	37	chr22	32627028	32627028	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acatcaacgccacagtgtttCacgcattcagaaggtaccac	7	13	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:32627028C>G	uc003ami.2	-	10	1058	c.1056G>C	c.(1054-1056)GTG>GTC	p.V352V		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	352	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CACAGTGTTTCACGCATTCAG	0.493													0	0	0	0.00499	0	13	46										G	32627028	C	G	32627028	2	3	96	1	0	0	0	0	0	0	0	1	14667	813	29	1		1	SLC5A4	22	32627028	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	438270	32627028	18677538	985	29461										
MYH9	4627	broad.mit.edu	37	chr22	36745254	36745254	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gaagtttttatccacatagaGatacttatcggcagcttgct	8	8	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:36745254G>C	uc003apg.2	-	2	259	c.28C>G	c.(28-30)CTC>GTC	p.L10V	MYH9_uc003api.1_Missense_Mutation_p.L10V	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	10	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TCCACATAGAGATACTTATCG	0.517			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.001855	0	13	42										C	36745254	G	C	36745254	3	2	96	1	0	0	0	0	1	0	0	0	10042	942	33	1	6014	1	MYH9	22	36745254	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4118226	36745254	14559312	986	29462										
CARD10	29775	broad.mit.edu	37	chr22	37902202	37902202	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aatcttgacccgctcaccttGaggcaggtgccaccctgggc	11	15	2	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:37902202G>C	uc003asx.1	-	7	1383	c.1380C>G	c.(1378-1380)CTC>CTG	p.L460L	CARD10_uc003ast.1_RNA|CARD10_uc003asw.1_Silent_p.L174L|CARD10_uc003asy.1_Silent_p.L460L	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	460					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CGCTCACCTTGAGGCAGGTGC	0.672													0	0	0	0.007413	0	14	30										C	37902202	G	C	37902202	2	2	96	1	0	0	0	0	0	0	0	1	2644	1277	45	1		1	CARD10	22	37902202	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1156948	37902202	13402364	987	29463										
APOBEC3D	140564	broad.mit.edu	37	chr22	39378461	39378461	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtatctaagaggctgaacatGaatccacagatcaggtaccg	10	9	2	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:39378461G>C	uc011aoe.1	+	1	57	c.3G>C	c.(1-3)ATG>ATC	p.M1I	APOBEC3A_uc011aoc.1_Intron|APOBEC3B_uc003awo.1_Missense_Mutation_p.M1I|APOBEC3B_uc003awp.1_Missense_Mutation_p.M1I|APOBEC3B_uc003awq.1_RNA|APOBEC3D_uc011aod.1_Missense_Mutation_p.M1I|APOBEC3D_uc011aof.1_Missense_Mutation_p.M1I	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	1					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					GGCTGAACATGAATCCACAGA	0.597													0	0	0	0.002445	0	30	19										C	39378461	G	C	39378461	3	2	96	1	0	0	0	0	1	0	0	0	792	1290	45	1		1	APOBEC3D	22	39378461	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	1476259	39378461	11926105	988	29464										
APOBEC3G	60489	broad.mit.edu	37	chr22	39483104	39483104	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gatgagcacagccaagacctGagtgggaggctgcgggccat	16	10	0	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:39483104G>T	uc003awx.2	+	7	1455	c.1113G>T	c.(1111-1113)CTG>CTT	p.L371L	APOBEC3G_uc003awy.2_Silent_p.L304L	NM_021822	NP_068594	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	371					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2	Melanoma(58;0.04)					GCCAAGACCTGAGTGGGAGGC	0.483													1	0	6.07407e-21	0.007291	7.71311e-21	27	70										T	39483104	G	T	39483104	2	4	96	1	0	0	0	0	0	0	0	1	794	1277	45	3		3	APOBEC3G	22	39483104	Silent	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	104643	39483104	11821462	989	29465										
TNRC6B	23112	broad.mit.edu	37	chr22	40661277	40661277	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gacatccagggaacagcagtCaaagatggaaaatgcgggtg	14	7	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:40661277C>G	uc011aor.1	+	5	1254	c.1043C>G	c.(1042-1044)TCA>TGA	p.S348*	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.S348*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.S152*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	348					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GAACAGCAGTCAAAGATGGAA	0.428													0	0	0	0.003954	0	24	64										G	40661277	C	G	40661277	4	3	96	1	0	0	0	0	0	1	0	0	16338	838	29	1	1182	1	TNRC6B	22	40661277	Nonsense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	1178173	40661277	10643289	990	29466										
CELSR1	9620	broad.mit.edu	37	chr22	46759985	46759985	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cccggctccctcccagggctCttgactgtgatggcgcagtc	12	16	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:46759985C>T	uc003bhw.1	-	34	8943	c.8943G>A	c.(8941-8943)AAG>AAA	p.K2981K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2981	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCCCAGGGCTCTTGACTGTGA	0.687													0	0	0	0.002299	0	22	50										T	46759985	C	T	46759985	2	4	96	1	0	0	0	0	0	0	0	1	3221	912	32	1		1	CELSR1	22	46759985	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6098708	46759985	4544581	991	29467										
CELSR1	9620	broad.mit.edu	37	chr22	46859643	46859643	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ctcgcaggtgtagccgccctCgcggctgcggcagcggccgt	16	16	0	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:46859643C>T	uc003bhw.1	-	2	4144	c.4144G>A	c.(4144-4146)GAG>AAG	p.E1382K		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1382	Extracellular (Potential).|EGF-like 2; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TAGCCGCCCTCGCGGCTGCGG	0.687													0	0	0	0.001168	0	5	15										T	46859643	C	T	46859643	3	4	96	1	0	0	0	0	1	0	0	0	3221	893	31	1	5036	1	CELSR1	22	46859643	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	99658	46859643	4444923	992	29468										
MLC1	23209	broad.mit.edu	37	chr22	50523236	50523236	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agctgcaggtcgctcggcttCgcgtctggggcatagctggc	16	12	1	0			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:50523236C>T	uc003bjg.1	-	2	369	c.96G>A	c.(94-96)GCG>GCA	p.A32A	MLC1_uc011arl.1_Silent_p.A32A|MLC1_uc003bjh.1_Silent_p.A32A|MLC1_uc011arm.1_Silent_p.A32A|MLC1_uc011arn.1_Intron|MLC1_uc011aro.1_Silent_p.A32A	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	32						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CGCTCGGCTTCGCGTCTGGGG	0.637													0	0	0	0.001882	0	22	54										T	50523236	C	T	50523236	2	4	96	1	0	0	0	0	0	0	0	1	9612	871	31	1		1	MLC1	22	50523236	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	3663593	50523236	781330	993	29469										
TUBGCP6	85378	broad.mit.edu	37	chr22	50657502	50657502	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gtgtccggaggccaccttctCaaagagcaggtcgctgaggg	15	11	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chr22:50657502C>G	uc003bkb.1	-	20	5133	c.4621G>C	c.(4621-4623)GAG>CAG	p.E1541Q	TUBGCP6_uc003bka.1_Missense_Mutation_p.E628Q|TUBGCP6_uc010har.1_Missense_Mutation_p.E1533Q|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1541					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GCCACCTTCTCAAAGAGCAGG	0.657													0	0	0	0.000602	0	4	47										G	50657502	C	G	50657502	3	3	96	1	0	0	0	0	1	0	0	0	16767	835	29	1	862	1	TUBGCP6	22	50657502	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	134266	50657502	647064	994	29470										
TLR7	51284	broad.mit.edu	37	chrX	12903875	12903875	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	cataccagacatctccccagCgtcctttcacagactggacc	6	17	2	2	rs143823510		TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:12903875C>A	uc004cvc.2	+	3	387	c.248C>A	c.(247-249)GCG>GAG	p.A83E		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	83	Extracellular (Potential).|LRR 2.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity	p.A83A(1)		ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATCTCCCCAGCGTCCTTTCAC	0.483													1	0	1.46156e-29	0.00361	1.86582e-29	51	38										A	12903875	C	A	12903875	3	1	96	1	0	0	0	0	1	0	0	0	15953	768	27	4	254	4	TLR7	23	12903875	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08		12903875	142366685	995	29471										
REPS2	9185	broad.mit.edu	37	chrX	17040287	17040287	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tgatgtcaaagaatgatggtGagatacgatttgggaaccca	12	5	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:17040287G>A	uc004cxv.1	+	3	610	c.439G>A	c.(439-441)GAG>AAG	p.E147K	REPS2_uc004cxw.1_Missense_Mutation_p.E147K|REPS2_uc011miw.1_Missense_Mutation_p.E7K	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	147	EH 1.				epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					GAATGATGGTGAGATACGATT	0.388													0	0	0	0.00361	0	107	57										A	17040287	G	A	17040287	3	1	96	1	0	0	0	0	1	0	0	0	13229	1291	45	1	449	1	REPS2	23	17040287	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	4136412	17040287	138230273	996	29472										
NHS	4810	broad.mit.edu	37	chrX	17744900	17744900	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccagggaaatgaagctgcctCttgatttcgccaacacgcct	9	13	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:17744900C>G	uc004cxx.2	+	6	2949	c.2611C>G	c.(2611-2613)CTT>GTT	p.L871V	NHS_uc011mix.1_Missense_Mutation_p.L892V|NHS_uc004cxy.2_Missense_Mutation_p.L715V|NHS_uc004cxz.2_Missense_Mutation_p.L694V|NHS_uc004cya.2_Missense_Mutation_p.L594V	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	871						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GAAGCTGCCTCTTGATTTCGC	0.473													0	0	0	0.006122	0	19	53										G	17744900	C	G	17744900	3	3	96	1	0	0	0	0	1	0	0	0	10411	913	32	1	2738	1	NHS	23	17744900	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	704613	17744900	137525660	997	29473										
FAM48B2	170067	broad.mit.edu	37	chrX	24329257	24329257	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aagcagactcaacacagcagCctggggctggggctgcagac	14	12	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:24329257C>T	uc011mjw.1	-	1	2176	c.2176G>A	c.(2176-2178)GCT>ACT	p.A726T		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	726	Gln-rich.										0						AACACAGCAGCCTGGGGCTGG	0.607													0	0	0	0.000602	0	5	2										T	24329257	C	T	24329257	3	4	96	1	0	0	0	0	1	0	0	0	5574	739	26	2	280	2	FAM48B2	23	24329257	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	6584357	24329257	130941303	998	29474										
KDM6A	7403	broad.mit.edu	37	chrX	44942739	44942739	+	Frame_Shift_Del	DEL	C	C	-													0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacatgagctgactaaacttCctgcttttgtgcgtgtcgta							TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:44942739delC	uc004dge.3	+	23	3694	c.3319delC	c.(3319-3321)CCTfs	p.P1107fs	KDM6A_uc011mkz.1_Frame_Shift_Del_p.P1159fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.P1062fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.P1114fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.P811fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.P746fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1107	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GACTAAACTTCCTGCTTTTGT	0.403			D|N|F|S		renal|oesophageal SCC|MM													29	10	---	---								-	44942739	C	-	44942739	7	5	96	1	0	1	0	1	0	0	0	0	8137	855	30	0	3409	0	KDM6A	23	44942739	Frame_Shift_Del	DEL	C	TCGA-G2-A2EO-01A-11D-A17V-08	20613482	44942739	110327821	999	29475										
ZNF41	7592	broad.mit.edu	37	chrX	47307191	47307191	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agcacatatattgggcttctCacctgtgtggattttctgat	9	8	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:47307191C>T	uc004dhs.3	-	4	2171	c.2104G>A	c.(2104-2106)GAG>AAG	p.E702K	ZNF41_uc004dhu.3_Missense_Mutation_p.E694K|ZNF41_uc004dht.3_Missense_Mutation_p.E574K|ZNF41_uc004dhv.3_Missense_Mutation_p.E670K|ZNF41_uc004dhw.3_Missense_Mutation_p.E662K|ZNF41_uc004dhy.3_Missense_Mutation_p.E660K|ZNF41_uc004dhx.3_Missense_Mutation_p.E660K|ZNF41_uc011mlm.1_Missense_Mutation_p.E574K	NM_153380	NP_700359	P51814	ZNF41_HUMAN	zinc finger protein 41	702						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3		all_lung(315;0.000129)				TTGGGCTTCTCACCTGTGTGG	0.438													0	0	0	0.002836	0	33	42										T	47307191	C	T	47307191	3	4	96	1	0	0	0	0	1	0	0	0	17886	835	29	1	365	1	ZNF41	23	47307191	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	2364452	47307191	107963369	1000	29476										
GPR173	54328	broad.mit.edu	37	chrX	53106214	53106214	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	tacgccaagcgcatgacactCtggacatgcgcggctgtcat	11	13	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:53106214C>G	uc004dru.2	+	2	669	c.411C>G	c.(409-411)CTC>CTG	p.L137L		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	137	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GCATGACACTCTGGACATGCG	0.587													0	0	0	0.005443	0	28	14										G	53106214	C	G	53106214	2	3	96	1	0	0	0	0	0	0	0	1	6671	900	32	1		1	GPR173	23	53106214	Silent	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	5799023	53106214	102164346	1001	29477										
UBQLN2	29978	broad.mit.edu	37	chrX	56590553	56590553	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ttgccggaaaaatcttaaaaGatcaagataccttgatccag	7	8	2	3			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:56590553G>C	uc004dus.2	+	1	482	c.247G>C	c.(247-249)GAT>CAT	p.D83H	UBQLN2_uc011moq.1_Missense_Mutation_p.D83H	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	83	Ubiquitin-like.					cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						AATCTTAAAAGATCAAGATAC	0.483													0	0	0	0.008291	0	11	25										C	56590553	G	C	56590553	3	2	96	1	0	0	0	0	1	0	0	0	16894	942	33	1	249	1	UBQLN2	23	56590553	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	3484339	56590553	98680007	1002	29478										
MED12	9968	broad.mit.edu	37	chrX	70339888	70339888	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccattttcagtaagaaggaaGaggtgtttgggtacttagcc	12	6	1	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:70339888G>C	uc004dyy.2	+	4	620	c.421G>C	c.(421-423)GAG>CAG	p.E141Q	MED12_uc011mpq.1_Missense_Mutation_p.E141Q|MED12_uc004dyz.2_Missense_Mutation_p.E141Q|MED12_uc004dza.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	141					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TAAGAAGGAAGAGGTGTTTGG	0.468													0	0	0	0.004289	0	38	34										C	70339888	G	C	70339888	3	2	96	1	0	0	0	0	1	0	0	0	9428	943	33	1	435	1	MED12	23	70339888	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	13749335	70339888	84930672	1003	29479										
ATRX	546	broad.mit.edu	37	chrX	76888758	76888758	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	actcttcacattccttccttGagcaagatttctatacatct	3	12	4	2			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:76888758G>C	uc004ecp.3	-	19	5303	c.5071C>G	c.(5071-5073)CAA>GAA	p.Q1691E	ATRX_uc004ecq.3_Missense_Mutation_p.Q1653E|ATRX_uc004eco.3_Missense_Mutation_p.Q1476E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1691	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCCTTCCTTGAGCAAGATTT	0.393			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.00361	0	168	127										C	76888758	G	C	76888758	3	2	96	1	0	0	0	0	1	0	0	0	1208	1299	45	1	2475	1	ATRX	23	76888758	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6548870	76888758	78381802	1004	29480										
TGIF2LX	90316	broad.mit.edu	37	chrX	89177499	89177499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccacccacctgcagagcaccGaggcgtctgtgccggccaag	12	17	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:89177499G>A	uc004efe.2	+	2	464	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	139						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GCAGAGCACCGAGGCGTCTGT	0.582													0	0	0	0.001786	0	30	33										A	89177499	G	A	89177499	3	1	96	1	0	0	0	0	1	0	0	0	15824	1059	37	1	417	1	TGIF2LX	23	89177499	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	12288741	89177499	66093061	1005	29481										
NOX1	27035	broad.mit.edu	37	chrX	100118475	100118475	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	aggagtggttgggactcactGagcaggtgcccctcaggaag	16	9	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:100118475G>A	uc004egj.2	-	3	457	c.251C>T	c.(250-252)TCA>TTA	p.S84L	uc010nnf.2_Intron|NOX1_uc004egl.3_Missense_Mutation_p.S84L|NOX1_uc010nne.2_Intron	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	84	Cytoplasmic (Potential).|Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						GGGACTCACTGAGCAGGTGCC	0.532													0	0	0	0.00308	0	6	21										A	100118475	G	A	100118475	3	1	96	1	0	0	0	0	1	0	0	0	10556	1304	45	1	1487	1	NOX1	23	100118475	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	10940976	100118475	55152085	1006	29482										
TIMM8A	1678	broad.mit.edu	37	chrX	100603636	100603636	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	ccaaacccgccgcggaggaaGaggaggaggaatccatccca	13	13	0	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:100603636G>C	uc004ehd.2	-	1	322	c.17C>G	c.(16-18)TCT>TGT	p.S6C	TIMM8A_uc011mri.1_Missense_Mutation_p.S6C	NM_004085	NP_004076	O60220	TIM8A_HUMAN	translocase of inner mitochondrial membrane 8	6					nervous system development|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	protein binding				0						CGCGGAGGAAGAGGAGGAGGA	0.607													0	0	0	0.00333	0	21	29										C	100603636	G	C	100603636	3	2	96	1	0	0	0	0	1	0	0	0	15911	942	33	1	303	1	TIMM8A	23	100603636	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	485161	100603636	54666924	1007	29483										
RGAG1	57529	broad.mit.edu	37	chrX	109695911	109695911	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	acaaatgacagccacagtctCtggagggatgtccatgccac	10	12	1	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:109695911C>G	uc004eor.1	+	3	2312	c.2066C>G	c.(2065-2067)TCT>TGT	p.S689C	RGAG1_uc011msr.1_Missense_Mutation_p.S689C	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	689										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GCCACAGTCTCTGGAGGGATG	0.512													0	0	0	0.005443	0	26	21										G	109695911	C	G	109695911	3	3	96	1	0	0	0	0	1	0	0	0	13274	913	32	1	2068	1	RGAG1	23	109695911	Missense_Mutation	SNP	C	TCGA-G2-A2EO-01A-11D-A17V-08	9092275	109695911	45574649	1008	29484										
UTP14A	10813	broad.mit.edu	37	chrX	129058892	129058892	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	attccccaggtccagagagaGgaacctgccccagaagaaga	11	12	0	5			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:129058892G>C	uc004euz.2	+	12	1498	c.1470G>C	c.(1468-1470)GAG>GAC	p.E490D	UTP14A_uc011mup.1_Missense_Mutation_p.E438D|UTP14A_uc011muq.1_Missense_Mutation_p.E436D	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	490					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TCCAGAGAGAGGAACCTGCCC	0.478													0	0	0	0.005524	0	35	99										C	129058892	G	C	129058892	3	2	96	1	0	0	0	0	1	0	0	0	17092	991	35	4	1516	4	UTP14A	23	129058892	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	19362981	129058892	26211668	1009	29485										
HTATSF1	27336	broad.mit.edu	37	chrX	135593382	135593382	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	agaaggcaatcccgtaagagGatctgaagaggatagtccta	12	7	1	4			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:135593382G>T	uc004ezw.2	+	10	1900	c.1478G>T	c.(1477-1479)GGA>GTA	p.G493V	HTATSF1_uc004ezx.2_Missense_Mutation_p.G493V	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	493	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCCGTAAGAGGATCTGAAGAG	0.443													1	0	1.99824e-07	0.00499	2.42619e-07	18	23										T	135593382	G	T	135593382	3	4	96	1	0	0	0	0	1	0	0	0	7433	1174	41	3	1512	3	HTATSF1	23	135593382	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	6534490	135593382	19677178	1010	29486										
GABRE	2564	broad.mit.edu	37	chrX	151138714	151138714	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	caggatagtgttcaggatgcGagaggcttctggcagtttgc	15	7	2	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:151138714G>A	uc004ffi.2	-	2	271	c.217C>T	c.(217-219)CGC>TGC	p.R73C	GABRE_uc011myd.1_RNA|GABRE_uc011mye.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	73	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTCAGGATGCGAGAGGCTTCT	0.547													0	0	0	0.004656	0	24	101										A	151138714	G	A	151138714	3	1	96	1	0	0	0	0	1	0	0	0	6170	1058	37	1	1335	1	GABRE	23	151138714	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	15545332	151138714	4131846	1011	29487										
FLNA	2316	broad.mit.edu	37	chrX	153599343	153599343	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.608955223880597	612	8.82460861554233e-265	4.49217747440273	4.96307692307692	4.11661349693252	0.542978817408572	0.703427880543598	476	gggccgctggttgtgcttgcGgtgcatcttcttctggctga	15	10	3	1			TCGA-G2-A2EO-01A-11D-A17V-08	TCGA-G2-A2EO-11A-21D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebb5cdb6-df4a-436d-b4a6-1655d263e3dd	0b75e374-8428-4022-a2ec-06b625c6ab92	g.chrX:153599343G>C	uc004fkk.2	-	2	520	c.271C>G	c.(271-273)CGC>GGC	p.R91G	FLNA_uc010nuu.1_Missense_Mutation_p.R91G	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	91	CH 1.|Actin-binding.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTGTGCTTGCGGTGCATCTTC	0.607													0	0	0	0.003163	0	14	9										C	153599343	G	C	153599343	3	2	96	1	0	0	0	0	1	0	0	0	5933	1116	39	4	7860	4	FLNA	23	153599343	Missense_Mutation	SNP	G	TCGA-G2-A2EO-01A-11D-A17V-08	2460629	153599343	1671217	1012	29488										
GNB1	2782	broad.mit.edu	37	chr1	1721920	1721920	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccagagtttggctgaagcatCacaagcaccagagacgaaca	10	11	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:1721920C>T	uc001aif.2	-	9	945	c.613G>A	c.(613-615)GAT>AAT	p.D205N	GNB1_uc009vky.2_Missense_Mutation_p.D105N	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	205	WD 4.				cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GCTGAAGCATCACAAGCACCA	0.562													0	0	0	0.004656	0	24	48										T	1721920	C	T	1721920	3	4	97	1	0	0	0	0	1	0	0	0	6515	826	29	1	421	1	GNB1	1	1721920	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08		1721920	247528701	1	29489										
WDR8	49856	broad.mit.edu	37	chr1	3548889	3548889	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtctgtaaggagactgggacAgaggcgatctcatctagaac	13	8	3	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:3548889A>G	uc001ako.2	-	10	1044	c.936T>C	c.(934-936)TCT>TCC	p.S312S	WDR8_uc001akn.3_Silent_p.S312S|WDR8_uc010nzi.1_3'UTR	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	312						centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGACTGGGACAGAGGCGATCT	0.537													0	0	0	0.008361	0	26	86										G	3548889	A	G	3548889	2	3	97	1	0	0	0	0	0	0	0	1	17326	175	7	5		5	WDR8	1	3548889	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1826969	3548889	245701732	2	29490										
CAMTA1	23261	broad.mit.edu	37	chr1	7806147	7806147	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccagacagctttccggaaatAcaaggtaaactagaacagaa	8	9	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:7806147A>G	uc001aoi.2	+	18	4820	c.4613A>G	c.(4612-4614)TAC>TGC	p.Y1538C	CAMTA1_uc001aok.3_Missense_Mutation_p.Y581C|CAMTA1_uc001aoj.2_Missense_Mutation_p.Y494C|CAMTA1_uc009vmf.2_Missense_Mutation_p.Y128C	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1538					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TTCCGGAAATACAAGGTAAAC	0.413													0	0	0	0.002299	0	22	67										G	7806147	A	G	7806147	3	3	97	1	0	0	0	0	1	0	0	0	2613	391	14	5	4683	5	CAMTA1	1	7806147	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	4257258	7806147	241444474	3	29491										
UBE4B	10277	broad.mit.edu	37	chr1	10239490	10239490	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcagaccctctgatggacacCctcatgacagaccccgtgcg	10	16	2	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:10239490C>G	uc001aqs.3	+	27	4430	c.3717C>G	c.(3715-3717)ACC>ACG	p.T1239T	UBE4B_uc001aqr.3_Silent_p.T1110T|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.T694T|UBE4B_uc001aqu.2_Silent_p.T120T	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	1239	U-box.				apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		TGATGGACACCCTCATGACAG	0.572													0	0	0	0.001882	0	21	109										G	10239490	C	G	10239490	2	3	97	1	0	0	0	0	0	0	0	1	16880	610	22	4		4	UBE4B	1	10239490	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2433343	10239490	239011131	4	29492										
UBR4	23352	broad.mit.edu	37	chr1	19447716	19447716	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttctttttcttctttcttgcTctttttagtggaagacttgg	7	7	5	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:19447716T>C	uc001bbi.2	-	68	10112	c.10108A>G	c.(10108-10110)AGC>GGC	p.S3370G	UBR4_uc001bbk.1_Missense_Mutation_p.S1017G	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3370	Ser-rich.				interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCTTTCTTGCTCTTTTTAGTG	0.473													0	0	0	0.003755	0	28	96										C	19447716	T	C	19447716	3	2	97	1	0	0	0	0	1	0	0	0	16901	1551	54	5	5599	5	UBR4	1	19447716	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	9208226	19447716	229802905	5	29493										
NBPF3	84224	broad.mit.edu	37	chr1	21800042	21800042	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctctcattgactcatcctctCatgatgaatggttggatgct	8	10	3	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:21800042C>A	uc001ber.2	+	7	1254	c.904C>A	c.(904-906)CAT>AAT	p.H302N	NBPF3_uc001bes.2_Missense_Mutation_p.H246N|NBPF3_uc009vqb.2_Missense_Mutation_p.H302N|NBPF3_uc010odm.1_Missense_Mutation_p.H232N	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	302	NBPF 1.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTCATCCTCTCATGATGAATG	0.448													1	0	3.31034e-53	0.00361	4.5162e-53	81	255										A	21800042	C	A	21800042	3	1	97	1	0	0	0	0	1	0	0	0	10197	826	29	3	926	3	NBPF3	1	21800042	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2352326	21800042	227450579	6	29494										
USP48	84196	broad.mit.edu	37	chr1	22074634	22074634	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tatttgcacacatttacctgTcaaagacaaaacgcattagc	5	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:22074634T>A	uc001bfb.2	-	7	1143	c.905A>T	c.(904-906)GAC>GTC	p.D302V	USP48_uc010odq.1_Missense_Mutation_p.D302V|USP48_uc009vqc.2_Missense_Mutation_p.D302V|USP48_uc001bfc.2_Missense_Mutation_p.D302V|USP48_uc001bfe.1_Missense_Mutation_p.D302V|USP48_uc001bff.2_Missense_Mutation_p.D302V	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	302					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		CATTTACCTGTCAAAGACAAA	0.363													0	0	0	0.008871	0	20	40										A	22074634	T	A	22074634	3	1	97	1	0	0	0	0	1	0	0	0	17076	1667	58	5	2294	5	USP48	1	22074634	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	274592	22074634	227175987	7	29495										
HSPG2	3339	broad.mit.edu	37	chr1	22155497	22155497	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcacccgcaggctgccgtccTtgttgagacgctctgcagac	11	15	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:22155497T>A	uc001bfj.2	-	88	12108	c.12068A>T	c.(12067-12069)AAG>ATG	p.K4023M	HSPG2_uc001bfi.2_Missense_Mutation_p.K40M|HSPG2_uc009vqd.2_Missense_Mutation_p.K4024M	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	4023	Laminin G-like 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCTGCCGTCCTTGTTGAGACG	0.701													0	0	0	0.004672	0	3	6										A	22155497	T	A	22155497	3	1	97	1	0	0	0	0	1	0	0	0	7430	1609	56	5	1147	5	HSPG2	1	22155497	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	80863	22155497	227095124	8	29496										
HSPG2	3339	broad.mit.edu	37	chr1	22169324	22169324	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgacctgggcatgggcctgcCcgggcaccacacagttcaga	13	14	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:22169324C>A	uc001bfj.2	-	67	8889	c.8849G>T	c.(8848-8850)GGG>GTG	p.G2950V	HSPG2_uc009vqd.2_Missense_Mutation_p.G2951V	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2950	Ig-like C2-type 15.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	ATGGGCCTGCCCGGGCACCAC	0.657													1	0	1.13719e-10	0.008361	1.4475e-10	30	98										A	22169324	C	A	22169324	3	1	97	1	0	0	0	0	1	0	0	0	7430	623	22	4	4450	4	HSPG2	1	22169324	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	13827	22169324	227081297	9	29497										
MYOM3	127294	broad.mit.edu	37	chr1	24401849	24401849	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cttgaccctctgggggtccaGtgggcccttgtagtctttgg	14	11	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:24401849G>T	uc001bin.3	-	22	2981	c.2818C>A	c.(2818-2820)CTG>ATG	p.L940M	MYOM3_uc001bim.3_Missense_Mutation_p.L597M|MYOM3_uc001bio.2_Missense_Mutation_p.L940M	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	940										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGGGGGTCCAGTGGGCCCTTG	0.512													1	0	3.31993e-32	0.00361	4.48219e-32	53	146										T	24401849	G	T	24401849	3	4	97	1	0	0	0	0	1	0	0	0	10093	1020	36	4	1559	4	MYOM3	1	24401849	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2232525	24401849	224848772	10	29498										
TMEM57	55219	broad.mit.edu	37	chr1	25810726	25810726	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcgagggatccgctcagaaaTgggccagcttcggcaggaga	16	10	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:25810726T>G	uc001bkk.2	+	7	1476	c.1274T>G	c.(1273-1275)ATG>AGG	p.M425R	TMEM57_uc009vru.2_Missense_Mutation_p.M198R|TMEM57_uc009vrv.2_Missense_Mutation_p.M67R	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	425						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTCAGAAATGGGCCAGCTT	0.572													0	0	0	0.008871	0	21	94										G	25810726	T	G	25810726	3	3	97	1	0	0	0	0	1	0	0	0	16181	1464	51	5	1300	5	TMEM57	1	25810726	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1408877	25810726	223439895	11	29499										
DHDDS	79947	broad.mit.edu	37	chr1	26786621	26786621	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcctgcagttccagatgaacCatagcgtgcttcaggtaaga	10	10	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:26786621C>G	uc001bml.2	+	8	872	c.751C>G	c.(751-753)CAT>GAT	p.H251D	DHDDS_uc001bmk.2_Missense_Mutation_p.H251D|DHDDS_uc001bmm.2_Missense_Mutation_p.H158D|DHDDS_uc001bmn.2_Missense_Mutation_p.H212D|DHDDS_uc010ofd.1_Missense_Mutation_p.H217D	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b	251							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		CCAGATGAACCATAGCGTGCT	0.493													0	0	0	0.002222	0	42	134										G	26786621	C	G	26786621	3	3	97	1	0	0	0	0	1	0	0	0	4478	594	21	4	777	4	DHDDS	1	26786621	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	975895	26786621	222464000	12	29500										
RPS6KA1	6195	broad.mit.edu	37	chr1	26885394	26885394	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggaagacgacggcaagcctcGtgccccgcaggcacccctgc	13	17	0	1	rs147534995		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:26885394G>T	uc001bmr.1	+	14	1344	c.1181G>T	c.(1180-1182)CGT>CTT	p.R394L	RPS6KA1_uc010ofe.1_Missense_Mutation_p.R302L|RPS6KA1_uc010off.1_Missense_Mutation_p.R378L|RPS6KA1_uc001bms.1_Missense_Mutation_p.R403L|RPS6KA1_uc009vsl.1_Missense_Mutation_p.R237L	NM_002953	NP_002944	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	394					axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		GGCAAGCCTCGTGCCCCGCAG	0.637													1	0	4.47668e-21	0.003954	5.93084e-21	24	55										T	26885394	G	T	26885394	3	4	97	1	0	0	0	0	1	0	0	0	13650	1145	40	4	1374	4	RPS6KA1	1	26885394	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	98773	26885394	222365227	13	29501										
GRIK3	2899	broad.mit.edu	37	chr1	37267622	37267622	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aagggagaaacggatctcatCggccacggtgctgcagaagg	15	9	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:37267622C>T	uc001caz.2	-	16	2725	c.2590G>A	c.(2590-2592)GAT>AAT	p.D864N		NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	864	Cytoplasmic (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CGGATCTCATCGGCCACGGTG	0.582													0	0	0	0.001368	0	12	33										T	37267622	C	T	37267622	3	4	97	1	0	0	0	0	1	0	0	0	6775	884	31	1	173	1	GRIK3	1	37267622	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10382228	37267622	211982999	14	29502										
ZC3H12A	80149	broad.mit.edu	37	chr1	37941247	37941247	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcggccctggaactgcagatGaaggtggacttcttccggaa	13	10	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:37941247G>T	uc001cbb.3	+	2	300	c.150G>T	c.(148-150)ATG>ATT	p.M50I		NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	50					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AACTGCAGATGAAGGTGGACT	0.622													1	0	1.67942e-08	0.006122	2.09658e-08	17	64										T	37941247	G	T	37941247	3	4	97	1	0	0	0	0	1	0	0	0	17558	1290	45	3	152	3	ZC3H12A	1	37941247	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	673625	37941247	211309374	15	29503										
HEYL	26508	broad.mit.edu	37	chr1	40105218	40105218	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccccgcatcccggcccttacCtcagctggccctcttggccc	8	22	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:40105218C>G	uc001cdp.2	-	1	131	c.80G>C	c.(79-81)AGC>ACC	p.S27T		NM_014571	NP_055386	Q9NQ87	HEYL_HUMAN	hairy/enhancer-of-split related with YRPW	27					multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGGCCCTTACCTCAGCTGGCC	0.746													0	0	0	0.000602	0	5	13										G	40105218	C	G	40105218	3	3	97	1	0	0	0	0	1	0	0	0	7080	695	24	4	926	4	HEYL	1	40105218	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2163971	40105218	209145403	16	29504										
CAP1	10487	broad.mit.edu	37	chr1	40525127	40525127	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggtatgcagacagtccttcaAaaggtaagcagtccacagcc	10	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:40525127A>C	uc001cfa.3	+	2	338	c.109A>C	c.(109-111)AAA>CAA	p.K37Q	CAP1_uc010ojd.1_RNA|CAP1_uc001cey.3_Missense_Mutation_p.K37Q|CAP1_uc001cez.3_Missense_Mutation_p.K37Q|CAP1_uc009vvz.2_Missense_Mutation_p.K37Q|CAP1_uc010oje.1_Missense_Mutation_p.Q6H	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	37					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGTCCTTCAAAAGGTAAGCA	0.478													0	0	0	0.006122	0	19	52										C	40525127	A	C	40525127	3	2	97	1	0	0	0	0	1	0	0	0	2619	15	1	5	111	5	CAP1	1	40525127	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	419909	40525127	208725494	17	29505										
SCMH1	22955	broad.mit.edu	37	chr1	41493986	41493986	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcagcagggccttgccatcGatctcctggggggtggggag	18	10	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:41493986G>T	uc001cgo.2	-	16	2174	c.1863C>A	c.(1861-1863)ATC>ATA	p.I621I	SCMH1_uc010ojr.1_Silent_p.I441I|SCMH1_uc001cgp.2_Silent_p.I560I|SCMH1_uc001cgr.2_Silent_p.I538I|SCMH1_uc001cgs.2_Silent_p.I609I|SCMH1_uc001cgt.2_Silent_p.I538I|SCMH1_uc001cgq.2_Silent_p.I552I	NM_001031694	NP_001026864	Q96GD3	SCMH1_HUMAN	sex comb on midleg 1 isoform 1	621	SAM.				anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				CCTTGCCATCGATCTCCTGGG	0.597													1	0	1.10923e-09	0.00278	1.39145e-09	24	63										T	41493986	G	T	41493986	2	4	97	1	0	0	0	0	0	0	0	1	13908	1048	37	3		3	SCMH1	1	41493986	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	968859	41493986	207756635	18	29506										
EBNA1BP2	10969	broad.mit.edu	37	chr1	43636436	43636436	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctatttcttaccttctgcatCtgcagatcagatttggccat	6	11	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:43636436C>T	uc001cin.2	-	4	635	c.438G>A	c.(436-438)CAG>CAA	p.Q146Q	EBNA1BP2_uc001cio.2_Silent_p.Q201Q|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_Silent_p.Q41Q|EBNA1BP2_uc010ojx.1_Silent_p.Q201Q	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	146	Potential.				ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTTCTGCATCTGCAGATCAG	0.453													0	0	0	0.00361	0	48	180										T	43636436	C	T	43636436	2	4	97	1	0	0	0	0	0	0	0	1	4885	912	32	1		1	EBNA1BP2	1	43636436	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2142450	43636436	205614185	19	29507										
CCDC24	149473	broad.mit.edu	37	chr1	44461475	44461475	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaggaacagaagaaggccatGgagcaggagctgcaggcatc	15	8	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:44461475G>A	uc001clj.2	+	8	819	c.648G>A	c.(646-648)ATG>ATA	p.M216I	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|CCDC24_uc001clk.2_Missense_Mutation_p.M171I|CCDC24_uc009vxc.2_Missense_Mutation_p.M180I	NM_152499	NP_689712	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	216	Potential.										0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				AGAAGGCCATGGAGCAGGAGC	0.557													0	0	0	0.00361	0	45	153										A	44461475	G	A	44461475	3	1	97	1	0	0	0	0	1	0	0	0	2799	1348	47	2	674	2	CCDC24	1	44461475	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	825039	44461475	204789146	20	29508										
CCDC24	149473	broad.mit.edu	37	chr1	44461719	44461719	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcctctggagccctaccttCgacctcgaggccagtcggct	10	17	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:44461719C>T	uc001clj.2	+	9	982	c.811C>T	c.(811-813)CGA>TGA	p.R271*	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|CCDC24_uc001clk.2_Silent_p.F224F|CCDC24_uc009vxc.2_Nonsense_Mutation_p.R235*	NM_152499	NP_689712	Q8N4L8	CCD24_HUMAN	coiled-coil domain containing 24	271											0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCCCTACCTTCGACCTCGAGG	0.677													0	0	0	0.002222	0	44	84										T	44461719	C	T	44461719	4	4	97	1	0	0	0	0	0	1	0	0	2799	876	31	1	841	1	CCDC24	1	44461719	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	244	44461719	204788902	21	29509										
NASP	4678	broad.mit.edu	37	chr1	46072194	46072194	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaaacgccttggaaggtgtgCatgtggaagaggaagaagga	17	4	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:46072194C>A	uc001coi.1	+	5	442	c.340C>A	c.(340-342)CAT>AAT	p.H114N	NASP_uc010olq.1_Missense_Mutation_p.H77N|NASP_uc001coh.1_Missense_Mutation_p.H116N|NASP_uc001coj.1_Missense_Mutation_p.H114N|NASP_uc010olr.1_Missense_Mutation_p.H50N|NASP_uc001cok.1_5'UTR	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	114	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GGAAGGTGTGCATGTGGAAGA	0.393													1	0	1.36565e-18	0.00278	1.79399e-18	22	62										A	46072194	C	A	46072194	3	1	97	1	0	0	0	0	1	0	0	0	10172	710	25	4	435	4	NASP	1	46072194	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1610475	46072194	203178427	22	29510										
ELAVL4	1996	broad.mit.edu	37	chr1	50661283	50661283	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgataagaggattgaggcaGaagaagccatcaaagggctg	14	5	1	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:50661283G>A	uc001csb.2	+	5	827	c.559G>A	c.(559-561)GAA>AAA	p.E187K	ELAVL4_uc001cry.3_Missense_Mutation_p.E190K|ELAVL4_uc001crz.3_Missense_Mutation_p.E187K|ELAVL4_uc001csa.3_Missense_Mutation_p.E204K|ELAVL4_uc001csc.3_Missense_Mutation_p.E187K|ELAVL4_uc009vyu.2_Missense_Mutation_p.E192K|ELAVL4_uc010omz.1_Missense_Mutation_p.E192K	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	187	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GATTGAGGCAGAAGAAGCCAT	0.522													0	0	0	0.002222	0	41	108										A	50661283	G	A	50661283	3	1	97	1	0	0	0	0	1	0	0	0	5052	943	33	1	676	1	ELAVL4	1	50661283	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4589089	50661283	198589338	23	29511										
PRPF38A	84950	broad.mit.edu	37	chr1	52874277	52874277	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggggcactttacatgaggctGacaggcactgcaattgattg	13	8	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:52874277G>C	uc001ctv.3	+	3	530	c.327G>C	c.(325-327)CTG>CTC	p.L109L	PRPF38A_uc001ctw.3_Intron	NM_032864	NP_116253	Q8NAV1	PR38A_HUMAN	PRP38 pre-mRNA processing factor 38 (yeast)	109					mRNA processing|RNA splicing	spliceosomal complex					0						ACATGAGGCTGACAGGCACTG	0.453													0	0	0	0.001882	0	22	76										C	52874277	G	C	52874277	2	2	97	1	0	0	0	0	0	0	0	1	12567	1277	45	1		1	PRPF38A	1	52874277	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2212994	52874277	196376344	24	29512										
HOOK1	51361	broad.mit.edu	37	chr1	60309252	60309252	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acaattacaactagaacaatTacaggaagaaaacttcaggt	6	7	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:60309252T>C	uc009wad.2	+	10	872	c.770T>C	c.(769-771)TTA>TCA	p.L257S	HOOK1_uc001czo.2_Missense_Mutation_p.L257S|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Missense_Mutation_p.L215S	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	257	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					CTAGAACAATTACAGGAAGAA	0.323													0	0	0	0.00245	0	15	45										C	60309252	T	C	60309252	3	2	97	1	0	0	0	0	1	0	0	0	7282	1764	61	5	804	5	HOOK1	1	60309252	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	7434975	60309252	188941369	25	29513										
LRRC7	57554	broad.mit.edu	37	chr1	70504742	70504742	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcaatcctcaaggatcagtgGaagtgaaagccgaaaagagg	12	7	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:70504742G>A	uc001dep.2	+	19	3151	c.3121G>A	c.(3121-3123)GAA>AAA	p.E1041K	LRRC7_uc009wbg.2_Missense_Mutation_p.E325K|LRRC7_uc001deq.2_Missense_Mutation_p.E282K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1041						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AGGATCAGTGGAAGTGAAAGC	0.448													0	0	0	0.001368	0	13	48										A	70504742	G	A	70504742	3	1	97	1	0	0	0	0	1	0	0	0	9020	1175	41	1	3195	1	LRRC7	1	70504742	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	10195490	70504742	178745879	26	29514										
FPGT	8790	broad.mit.edu	37	chr1	74670826	74670826	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	attggaacaaccgaagaataTttgttttactttacctcaga	6	7	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:74670826T>C	uc001dgb.1	+	4	1132	c.1095T>C	c.(1093-1095)TAT>TAC	p.Y365Y	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	365					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						CCGAAGAATATTTGTTTTACT	0.328													0	0	0	0.002299	0	21	58										C	74670826	T	C	74670826	2	2	97	1	0	0	0	0	0	0	0	1	6037	1500	52	5		5	FPGT	1	74670826	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	4166084	74670826	174579795	27	29515										
ST6GALNAC5	81849	broad.mit.edu	37	chr1	77509952	77509952	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagggcatctgctgcacagtCggcaaggctcccagattgac	12	13	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:77509952C>G	uc001dhi.2	+	3	500	c.325C>G	c.(325-327)CGG>GGG	p.R109G	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	109	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						GCTGCACAGTCGGCAAGGCTC	0.617													0	0	0	0.00499	0	16	69										G	77509952	C	G	77509952	3	3	97	1	0	0	0	0	1	0	0	0	15226	875	31	1	335	1	ST6GALNAC5	1	77509952	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2839126	77509952	171740669	28	29516										
USP33	23032	broad.mit.edu	37	chr1	78177467	78177467	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caattcagtttttcttctttTttcaattttctccgcctcaa	2	11	6	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:78177467T>A	uc001dht.2	-	22	2811	c.2464A>T	c.(2464-2466)AAA>TAA	p.K822*	USP33_uc001dhs.2_Nonsense_Mutation_p.K543*|USP33_uc001dhu.2_Nonsense_Mutation_p.K791*|USP33_uc001dhv.2_Nonsense_Mutation_p.K627*|USP33_uc001dhw.2_Nonsense_Mutation_p.K814*	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	822	DUSP 2.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						TTTCTTCTTTTTTCAATTTTC	0.328													0	0	0	0.001882	0	22	59										A	78177467	T	A	78177467	4	1	97	1	0	0	0	0	0	1	0	0	17061	1850	64	5	392	5	USP33	1	78177467	Nonsense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	667515	78177467	171073154	29	29517										
OVGP1	5016	broad.mit.edu	37	chr1	111966296	111966296	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aactgaagcaataaacttttCacggttggcaaatgtggaca	9	7	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:111966296C>G	uc001eba.2	-	5	408	c.352G>C	c.(352-354)GAA>CAA	p.E118Q	OVGP1_uc001eaz.2_Missense_Mutation_p.E80Q|OVGP1_uc010owb.1_5'UTR|OVGP1_uc010owc.1_Missense_Mutation_p.E108Q	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	118					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		ATAAACTTTTCACGGTTGGCA	0.458													0	0	0	0.002299	0	20	72										G	111966296	C	G	111966296	3	3	97	1	0	0	0	0	1	0	0	0	11325	835	29	1	1712	1	OVGP1	1	111966296	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	33788829	111966296	137284325	30	29518										
MAGI3	260425	broad.mit.edu	37	chr1	114196636	114196636	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccaaaaacaaaccacctccAggaggtaagggctattgtat	8	10	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:114196636A>G	uc001edk.2	+	15	2806	c.2625A>G	c.(2623-2625)CCA>CCG	p.P875P	MAGI3_uc001edh.3_Silent_p.P900P|MAGI3_uc001edi.3_Silent_p.P875P|MAGI3_uc010owm.1_Silent_p.P900P|MAGI3_uc001edj.2_Silent_p.P596P	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	900	Interaction with LPAR2 and GRIN2B.|PDZ 5.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AACCACCTCCAGGAGGTAAGG	0.443													0	0	0	0.00361	0	71	185										G	114196636	A	G	114196636	2	3	97	1	0	0	0	0	0	0	0	1	9192	175	7	5		5	MAGI3	1	114196636	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2230340	114196636	135053985	31	29519										
CD101	9398	broad.mit.edu	37	chr1	117559992	117559992	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagatcaccttcactgccatCacagacagtggcacatatga	8	12	3	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:117559992C>G	uc010oxb.1	+	5	1567	c.1509C>G	c.(1507-1509)ATC>ATG	p.I503M	CD101_uc009whd.2_Missense_Mutation_p.I503M|CD101_uc010oxc.1_Missense_Mutation_p.I503M|CD101_uc010oxd.1_Missense_Mutation_p.I441M	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	503	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TCACTGCCATCACAGACAGTG	0.517													0	0	0	0.008361	0	30	88										G	117559992	C	G	117559992	3	3	97	1	0	0	0	0	1	0	0	0	2962	816	29	1	1527	1	CD101	1	117559992	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3363356	117559992	131690629	32	29520										
WDR3	10885	broad.mit.edu	37	chr1	118486119	118486119	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cactgaatccatccttgcctActcctcagcctgtcaggaca	6	16	2	1	rs141364091	byFrequency	TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:118486119A>G	uc010oxe.1	+	11	1264	c.1198A>G	c.(1198-1200)ACT>GCT	p.T400A	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	400						nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		ATCCTTGCCTACTCCTCAGCC	0.473													0	0	0	0.004672	0	3	100										G	118486119	A	G	118486119	3	3	97	1	0	0	0	0	1	0	0	0	17282	391	14	5	1236	5	WDR3	1	118486119	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	926127	118486119	130764502	33	29521										
SPAG17	200162	broad.mit.edu	37	chr1	118506543	118506543	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cttttggtcgtttatcataaTtgctgcttgttaaaacaggt	8	6	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:118506543T>C	uc001ehk.2	-	48	6619	c.6551A>G	c.(6550-6552)AAT>AGT	p.N2184S		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	2184						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTTATCATAATTGCTGCTTGT	0.333													0	0	0	0.00623	0	35	108										C	118506543	T	C	118506543	3	2	97	1	0	0	0	0	1	0	0	0	14979	1493	52	5	124	5	SPAG17	1	118506543	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	20424	118506543	130744078	34	29522										
NOTCH2	4853	broad.mit.edu	37	chr1	120462024	120462024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	attggcatctgcacctgcatCcaggagacgcttggcagcat	11	12	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:120462024C>T	uc001eik.2	-	31	5948	c.5692G>A	c.(5692-5694)GAT>AAT	p.D1898N		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1898	Cytoplasmic (Potential).|ANK 2.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCACCTGCATCCAGGAGACGC	0.617			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.003954	0	25	88										T	120462024	C	T	120462024	3	4	97	1	0	0	0	0	1	0	0	0	10548	855	30	1	1739	1	NOTCH2	1	120462024	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1955481	120462024	128788597	35	29523										
ITGA10	8515	broad.mit.edu	37	chr1	145541826	145541826	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcttggaggtggttcagaccCggcctatcctcatctccctg	10	14	4	1	rs140404631		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:145541826C>T	uc001eoa.2	+	29	3425	c.3349C>T	c.(3349-3351)CGG>TGG	p.R1117W	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Missense_Mutation_p.R986W|ITGA10_uc009wiw.2_Missense_Mutation_p.R974W|ITGA10_uc010oyw.1_Missense_Mutation_p.R1024W	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	1117	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGTTCAGACCCGGCCTATCCT	0.532													0	0	0	0.004878	0	34	111										T	145541826	C	T	145541826	3	4	97	1	0	0	0	0	1	0	0	0	7873	643	23	2	3463	2	ITGA10	1	145541826	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	25079802	145541826	103708795	36	29524										
FCGR1A	2209	broad.mit.edu	37	chr1	149762804	149762804	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgtttcaggcctccagttaCcaactcctgtctggtttcat	7	13	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:149762804C>T	uc001esp.3	+	6	906	c.856C>T	c.(856-858)CCA>TCA	p.P286S	HIST2H2BF_uc010pbj.1_Intron|FCGR1A_uc009wlg.2_RNA	NM_000566	NP_000557	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor	286	Extracellular (Potential).				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCTCCAGTTACCAACTCCTGT	0.423													0	0	0	0.003271	0	23	64										T	149762804	C	T	149762804	3	4	97	1	0	0	0	0	1	0	0	0	5779	507	18	2	878	2	FCGR1A	1	149762804	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4220978	149762804	99487817	37	29525										
HORMAD1	84072	broad.mit.edu	37	chr1	150679028	150679028	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	taactcttgaaatacacttaCacttgtataatgctcctgtt	4	9	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:150679028C>A	uc001evk.1	-	10	910	c.804_splice	c.e10+1	p.S268_splice	HORMAD1_uc001evl.1_Splice_Site_p.S261_splice|HORMAD1_uc001evm.1_Splice_Site_p.S188_splice	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1						blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			AATACACTTACACTTGTATAA	0.294													1	0	6.31663e-08	0.003163	7.82298e-08	13	106										A	150679028	C	A	150679028	5	1	97	1	0	0	0	0	0	0	1	0	7286	492	17	4	403	4	HORMAD1	1	150679028	Splice_Site	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	916224	150679028	98571593	38	29526										
PRUNE	58497	broad.mit.edu	37	chr1	150990968	150990968	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgaggctgaggaagtctttgTgccagttttaaatataaaac	10	5	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:150990968T>G	uc001ewh.1	+	3	294	c.158T>G	c.(157-159)GTG>GGG	p.V53G	PRUNE_uc001ewi.1_Intron|PRUNE_uc010pco.1_Intron|PRUNE_uc001ewj.1_Intron	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	53						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAAGTCTTTGTGCCAGTTTTA	0.383													0	0	0	0.00361	0	47	234										G	150990968	T	G	150990968	3	3	97	1	0	0	0	0	1	0	0	0	12640	1696	59	5	168	5	PRUNE	1	150990968	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	311940	150990968	98259653	39	29527										
C1orf56	54964	broad.mit.edu	37	chr1	151020344	151020344	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atggtccccgccgccggcgcGctgctgtgggtcctgctgct	15	16	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:151020344G>A	uc001ewn.2	+	1	86	c.21G>A	c.(19-21)GCG>GCA	p.A7A		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	7						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCGCCGGCGCGCTGCTGTGGG	0.687													0	0	0	0.00308	0	8	29										A	151020344	G	A	151020344	2	1	97	1	0	0	0	0	0	0	0	1	2048	1074	38	2		2	C1orf56	1	151020344	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	29376	151020344	98230277	40	29528										
KRTCAP2	200185	broad.mit.edu	37	chr1	155145217	155145217	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aactgcagggaggatacagtGagcgagaacacgaagagacc	14	8	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:155145217G>A	uc001fho.2	-	2	260	c.234C>T	c.(232-234)CTC>CTT	p.L78L	RAG1AP1_uc010pey.1_Intron|KRTCAP2_uc001fhp.1_Silent_p.L78L|TRIM46_uc009wpe.1_5'Flank|TRIM46_uc010pez.1_5'Flank|TRIM46_uc001fhq.2_5'Flank|TRIM46_uc001fhr.2_5'Flank|TRIM46_uc001fhs.1_5'Flank|TRIM46_uc001fht.1_5'Flank|TRIM46_uc010pfa.1_5'Flank|TRIM46_uc001fhu.1_5'Flank|TRIM46_uc009wpg.1_5'Flank|TRIM46_uc009wpf.2_5'Flank|TRIM46_uc001fhv.3_5'Flank|TRIM46_uc001fhw.1_5'Flank	NM_173852	NP_776251	Q8N6L1	KTAP2_HUMAN	keratinocyte associated protein 2	78	Helical; (Potential).					integral to membrane					0	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.18e-10)|all cancers(21;8.39e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGGATACAGTGAGCGAGAACA	0.617													0	0	0	0.00245	0	13	32										A	155145217	G	A	155145217	2	1	97	1	0	0	0	0	0	0	0	1	8578	1277	45	1		1	KRTCAP2	1	155145217	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4124873	155145217	94105404	41	29529										
HCN3	57657	broad.mit.edu	37	chr1	155247568	155247568	+	Missense_Mutation	SNP	C	C	T													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cggtcaacaagttctcccttCgggtgttcggcagccacaaa							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:155247568C>T	uc001fjz.1	+	1	195	c.187C>T	c.(187-189)CGG>TGG	p.R63W	RAG1AP1_uc010pey.1_Intron|CLK2_uc009wqm.2_5'Flank|HCN3_uc010pfz.1_5'UTR	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	63	Involved in subunit assembly (By similarity).|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GTTCTCCCTTCGGGTGTTCGG	0.622													0	0	0	0.001368	0	10	20										T	155247568	C	T	155247568	3	4	97	1	0	0	0	0	1	0	0	0	6998	875	31	1	189	1	HCN3	1	155247568	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	102351	155247568	94003053	42	29530	149	2								
HCN3	57657	broad.mit.edu	37	chr1	155247576	155247576	+	Silent	SNP	C	C	T													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aagttctcccttcgggtgttCggcagccacaaagcagtgga							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:155247576C>T	uc001fjz.1	+	1	203	c.195C>T	c.(193-195)TTC>TTT	p.F65F	RAG1AP1_uc010pey.1_Intron|CLK2_uc009wqm.2_5'Flank|HCN3_uc010pfz.1_5'UTR	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	65	Involved in subunit assembly (By similarity).|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TTCGGGTGTTCGGCAGCCACA	0.622													0	0	0	0.001368	0	11	18										T	155247576	C	T	155247576	2	4	97	1	0	0	0	0	0	0	0	1	6998	883	31	1		1	HCN3	1	155247576	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	8	155247576	94003045	43	29531	149	2								
ASH1L	55870	broad.mit.edu	37	chr1	155490915	155490915	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttgaaggacagtgttcattCttttcatccgtcatctttcc	6	10	5	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:155490915C>T	uc009wqq.2	-	2	876	c.396G>A	c.(394-396)AAG>AAA	p.K132K	ASH1L_uc001fkt.2_Silent_p.K132K|ASH1L_uc009wqr.1_Silent_p.K132K	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	132					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AGTGTTCATTCTTTTCATCCG	0.333													0	0	0	0.00361	0	78	271										T	155490915	C	T	155490915	2	4	97	1	0	0	0	0	0	0	0	1	1041	912	32	1		1	ASH1L	1	155490915	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	243339	155490915	93759706	44	29532										
SYT11	23208	broad.mit.edu	37	chr1	155838178	155838178	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccacctctccatcatctccaGaggaggatgtcatgctagga	9	13	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:155838178G>C	uc001fmg.2	+	2	720	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	153	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			ATCATCTCCAGAGGAGGATGT	0.517													0	0	0	0.00361	0	47	139										C	155838178	G	C	155838178	3	2	97	1	0	0	0	0	1	0	0	0	15464	943	33	1	463	1	SYT11	1	155838178	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	347263	155838178	93412443	45	29533										
SYT11	23208	broad.mit.edu	37	chr1	155838197	155838197	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agaggaggatgtcatgctagGatccctcaccttctcagtgg	12	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:155838197G>A	uc001fmg.2	+	2	739	c.476G>A	c.(475-477)GGA>GAA	p.G159E	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	159	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GTCATGCTAGGATCCCTCACC	0.537													0	0	0	0.00623	0	41	122										A	155838197	G	A	155838197	3	1	97	1	0	0	0	0	1	0	0	0	15464	1174	41	1	482	1	SYT11	1	155838197	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	19	155838197	93412424	46	29534										
SLC25A44	9673	broad.mit.edu	37	chr1	156180072	156180072	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atcctgaccttcagacagctGatggcagaagaagggccttg	12	10	1	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:156180072G>A	uc001fnp.2	+	4	1117	c.795G>A	c.(793-795)CTG>CTA	p.L265L	SLC25A44_uc010phc.1_Silent_p.L156L|SLC25A44_uc009wrr.2_Silent_p.L273L|SLC25A44_uc010phd.1_RNA|SLC25A44_uc010phe.1_RNA|PMF1_uc009wru.1_5'Flank|PMF1_uc001fnq.2_5'Flank|PMF1_uc001fnr.2_5'Flank|BGLAP_uc001fns.1_5'Flank	NM_014655	NP_055470	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	265	Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	Hepatocellular(266;0.158)					TCAGACAGCTGATGGCAGAAG	0.547													0	0	0	0.003271	0	34	69										A	156180072	G	A	156180072	2	1	97	1	0	0	0	0	0	0	0	1	14509	1277	45	1		1	SLC25A44	1	156180072	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	341875	156180072	93070549	47	29535										
APOA1BP	128240	broad.mit.edu	37	chr1	156561602	156561602	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgctctgcgagctggatgtcCaggctgcgggcgctgctggg	18	12	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:156561602C>T	uc001fph.2	+	1	45	c.6C>T	c.(4-6)TCC>TCT	p.S2S	APOA1BP_uc001fpg.2_Silent_p.S2S|APOA1BP_uc001fpi.2_Silent_p.S2S|APOA1BP_uc001fpj.2_5'UTR|APOA1BP_uc001fpk.2_5'UTR|APOA1BP_uc010php.1_5'UTR	NM_144772	NP_658985	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein precursor	2						extracellular region	protein binding			central_nervous_system(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCTGGATGTCCAGGCTGCGGG	0.612													0	0	0	0.004672	0	3	14										T	156561602	C	T	156561602	2	4	97	1	0	0	0	0	0	0	0	1	781	581	21	2		2	APOA1BP	1	156561602	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	381530	156561602	92689019	48	29536										
SH2D2A	9047	broad.mit.edu	37	chr1	156779017	156779017	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggcctcctgggacaggcctgGaccagctcttccgtaggaca	13	14	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:156779017G>T	uc001fqd.2	-	7	1120	c.980C>A	c.(979-981)TCC>TAC	p.S327Y	SH2D2A_uc001fqc.1_Missense_Mutation_p.S299Y|SH2D2A_uc009wsh.2_Missense_Mutation_p.S337Y|SH2D2A_uc001fqe.2_Missense_Mutation_p.S309Y|SH2D2A_uc010phs.1_Missense_Mutation_p.S327Y	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	327	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GACAGGCCTGGACCAGCTCTT	0.602													1	0	3.82633e-55	0.00361	5.22931e-55	95	240										T	156779017	G	T	156779017	3	4	97	1	0	0	0	0	1	0	0	0	14232	1174	41	3	197	3	SH2D2A	1	156779017	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	217415	156779017	92471604	49	29537										
CD1E	913	broad.mit.edu	37	chr1	158326312	158326312	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atattccatctttctcatccTgatctgtttgactgtgatag	6	9	3	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:158326312T>G	uc001fse.2	+	5	1168	c.929T>G	c.(928-930)CTG>CGG	p.L310R	CD1E_uc010pid.1_3'UTR|CD1E_uc010pie.1_3'UTR|CD1E_uc010pif.1_3'UTR|CD1E_uc001fsd.2_Silent_p.P275P|CD1E_uc001fsk.2_Missense_Mutation_p.L220R|CD1E_uc001fsj.2_Missense_Mutation_p.L165R|CD1E_uc001fsc.2_Missense_Mutation_p.L121R|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Missense_Mutation_p.L66R|CD1E_uc001fsf.2_Missense_Mutation_p.L310R|CD1E_uc001fry.2_Missense_Mutation_p.L255R|CD1E_uc001fsg.2_Silent_p.P86P|CD1E_uc001fsh.2_Missense_Mutation_p.L121R|CD1E_uc001fsi.2_Silent_p.P275P|CD1E_uc009wsv.2_Missense_Mutation_p.L211R|CD1E_uc001frz.2_Missense_Mutation_p.L220R|CD1E_uc009wsw.2_Intron	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	310	Helical; (Potential).				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TTTCTCATCCTGATCTGTTTG	0.393													0	0	0	0.000978	0	11	37										G	158326312	T	G	158326312	3	3	97	1	0	0	0	0	1	0	0	0	2978	1580	55	5	947	5	CD1E	1	158326312	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1547295	158326312	90924309	50	29538										
PPOX	5498	broad.mit.edu	37	chr1	161140930	161140930	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atagagagtgggcgccaggcAgcagtcagtgtcctgggcac	16	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:161140930A>C	uc001fyj.2	+	13	1688	c.1398A>C	c.(1396-1398)GCA>GCC	p.A466A	PPOX_uc001fyn.2_Silent_p.A174A|PPOX_uc001fyg.2_Silent_p.A466A|PPOX_uc001fyl.2_Silent_p.A432A|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Silent_p.A304A|PPOX_uc001fyh.2_Silent_p.A304A|PPOX_uc010pkg.1_Silent_p.A304A|PPOX_uc009wuc.1_Silent_p.A267A|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Intron	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	466					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GGCGCCAGGCAGCAGTCAGTG	0.512									Porphyria_Variegata				0	0	0	0.002852	0	40	174										C	161140930	A	C	161140930	2	2	97	1	0	0	0	0	0	0	0	1	12348	175	7	5		5	PPOX	1	161140930	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2814618	161140930	88109691	51	29539										
NR1I3	9970	broad.mit.edu	37	chr1	161201118	161201118	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	attgctctagcaccatctcaCcacgggctccatcttcaatt	5	15	4	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:161201118C>A	uc001fzx.2	-	6	897	c.694_splice	c.e6+1	p.V232_splice	TOMM40L_uc009wuf.1_Intron|NR1I3_uc001fzf.2_Splice_Site_p.V232_splice|NR1I3_uc001fzg.2_Splice_Site_p.V203_splice|NR1I3_uc001fzh.2_Splice_Site_p.V203_splice|NR1I3_uc001fzi.2_Splice_Site_p.V203_splice|NR1I3_uc001fzj.2_Splice_Site_p.V203_splice|NR1I3_uc001fzk.2_Splice_Site_p.D203_splice|NR1I3_uc001fzl.2_Splice_Site_p.D203_splice|NR1I3_uc001fzm.2_Splice_Site_p.V157_splice|NR1I3_uc001fzn.2_Splice_Site_p.D65_splice|NR1I3_uc009wug.2_Splice_Site_p.V65_splice|NR1I3_uc001fzp.2_Splice_Site_p.V232_splice|NR1I3_uc001fzo.2_Splice_Site_p.V65_splice|NR1I3_uc001fzq.2_Splice_Site_p.V128_splice|NR1I3_uc001fzr.2_Splice_Site_p.V128_splice|NR1I3_uc001fzs.2_Splice_Site_p.D65_splice|NR1I3_uc001fzt.2_Splice_Site_p.D65_splice|NR1I3_uc001fzu.2_Splice_Site_p.V99_splice|NR1I3_uc001fzv.2_Splice_Site_p.V99_splice|NR1I3_uc001fzw.2_Splice_Site_p.V232_splice|NR1I3_uc001fzy.2_Splice_Site_p.V232_splice|NR1I3_uc001fzz.2_Splice_Site_p.A232_splice|NR1I3_uc001gaa.2_Splice_Site_p.D232_splice|NR1I3_uc001gab.2_Splice_Site_p.D232_splice|NR1I3_uc001gac.2_Splice_Site_p.V203_splice|NR1I3_uc010pkm.1_Splice_Site_p.V203_splice|NR1I3_uc010pkn.1_Missense_Mutation_p.G232V	NM_001077480	NP_001070948	Q14994	NR1I3_HUMAN	constitutive androstane receptor isoform 2						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(1)|skin(1)	2	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CACCATCTCACCACGGGCTCC	0.507													1	0	6.32553e-13	0.004656	8.10459e-13	23	102										A	161201118	C	A	161201118	5	1	97	1	0	0	0	0	0	0	1	0	10621	521	18	4	489	4	NR1I3	1	161201118	Splice_Site	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	60188	161201118	88049503	52	29540										
C1orf9	51430	broad.mit.edu	37	chr1	172546905	172546905	+	Frame_Shift_Del	DEL	T	T	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgtgcttttattctttaggTtgagttgctatcacattttg							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:172546905delT	uc001giq.3	+	13	1602	c.1286delT	c.(1285-1287)GTTfs	p.V429fs	C1orf9_uc010pmm.1_Frame_Shift_Del_p.V429fs|C1orf9_uc009wwd.2_Frame_Shift_Del_p.V385fs|C1orf9_uc010pmn.1_Frame_Shift_Del_p.V392fs|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	429	SUN.				multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		ATTCTTTAGGTTGAGTTGCTA	0.289																		24	79	---	---								-	172546905	T	-	172546905	7	5	97	1	0	1	0	1	0	0	0	0	2067	1739	60	0	1336	0	C1orf9	1	172546905	Frame_Shift_Del	DEL	T	TCGA-G2-A2ES-01A-11D-A17V-08	11345787	172546905	76703716	53	29541										
TNN	63923	broad.mit.edu	37	chr1	175086247	175086247	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagcagagtagcactgtcctGacgggcctgaggccgggtgt	17	10	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:175086247G>A	uc001gkl.1	+	10	2405	c.2292G>A	c.(2290-2292)CTG>CTA	p.L764L		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	764	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCACTGTCCTGACGGGCCTGA	0.637													0	0	0	0.00632	0	27	95										A	175086247	G	A	175086247	2	1	97	1	0	0	0	0	0	0	0	1	16320	1277	45	1		1	TNN	1	175086247	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2539342	175086247	74164374	54	29542										
CEP350	9857	broad.mit.edu	37	chr1	179989993	179989993	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agaaatagttatgaacccatCaaagagtttcagaaagaagc	8	6	2	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:179989993C>A	uc001gnt.2	+	12	3467	c.3084C>A	c.(3082-3084)ATC>ATA	p.I1028I	CEP350_uc009wxl.2_Silent_p.I1027I|CEP350_uc001gnu.2_Silent_p.I862I	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1028						centrosome|nucleus|spindle				ovary(4)	4						ATGAACCCATCAAAGAGTTTC	0.403													1	0	1.33834e-09	0.007413	1.67615e-09	18	46										A	179989993	C	A	179989993	2	1	97	1	0	0	0	0	0	0	0	1	3254	816	29	3		3	CEP350	1	179989993	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4903746	179989993	69260628	55	29543										
DHX9	1660	broad.mit.edu	37	chr1	182845362	182845362	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctggctggaatctgatttatActatgcagaagcatttggaa	10	6	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:182845362A>G	uc001gpr.2	+	17	2156	c.1993A>G	c.(1993-1995)ACT>GCT	p.T665A	DHX9_uc001gps.2_Missense_Mutation_p.T451A	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	665	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TCTGATTTATACTATGCAGAA	0.373													0	0	0	0.002522	0	43	126										G	182845362	A	G	182845362	3	3	97	1	0	0	0	0	1	0	0	0	4516	391	14	5	2055	5	DHX9	1	182845362	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2855369	182845362	66405259	56	29544										
PTGS2	5743	broad.mit.edu	37	chr1	186648486	186648486	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttctccatagaatcctgtcCgggtacaatcgcacttatac	6	12	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:186648486C>A	uc001gsb.2	-	2	274	c.137G>T	c.(136-138)CGG>CTG	p.R46L	PTGS2_uc009wyo.2_5'UTR	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	46	EGF-like.				cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GAATCCTGTCCGGGTACAATC	0.438													1	0	4.4004e-07	0.00333	5.43251e-07	24	55										A	186648486	C	A	186648486	3	1	97	1	0	0	0	0	1	0	0	0	12756	652	23	4	1713	4	PTGS2	1	186648486	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3803124	186648486	62602135	57	29545										
CFH	3075	broad.mit.edu	37	chr1	196712595	196712595	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tattcagacacctcctgtgtGaatccgcccacagtacaaaa	6	13	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:196712595G>A	uc001gtj.3	+	20	3387	c.3147G>A	c.(3145-3147)GTG>GTA	p.V1049V		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	1049	Sushi 18.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CCTCCTGTGTGAATCCGCCCA	0.373													0	0	0	0.002299	0	22	115										A	196712595	G	A	196712595	2	1	97	1	0	0	0	0	0	0	0	1	3283	1277	45	1		1	CFH	1	196712595	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	10064109	196712595	52538026	58	29546										
BTG2	7832	broad.mit.edu	37	chr1	203276382	203276382	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctgcaccagctgctgcccaGcgagctgaccctgtgggtgg	15	14	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:203276382G>C	uc001gzq.2	+	2	364	c.293G>C	c.(292-294)AGC>ACC	p.S98T	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	98					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			CTGCTGCCCAGCGAGCTGACC	0.642													0	0	0	0.004007	0	17	80										C	203276382	G	C	203276382	3	2	97	1	0	0	0	0	1	0	0	0	1554	971	34	4	299	4	BTG2	1	203276382	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	6563787	203276382	45974239	59	29547										
KLHDC8A	55220	broad.mit.edu	37	chr1	205312535	205312535	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gccacccccgcccgggctgtGggcagccggggcaaggcggt	18	16	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:205312535G>C	uc001hcf.1	-	2	766	c.198C>G	c.(196-198)CCC>CCG	p.P66P	KLHDC8A_uc010prg.1_Intron|KLHDC8A_uc001hcg.1_Silent_p.P66P	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	66	Kelch 2.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CCCGGGCTGTGGGCAGCCGGG	0.677													0	0	0	0.006999	0	39	94										C	205312535	G	C	205312535	2	2	97	1	0	0	0	0	0	0	0	1	8362	1335	47	4		4	KLHDC8A	1	205312535	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2036153	205312535	43938086	60	29548										
SRGAP2	23380	broad.mit.edu	37	chr1	206628299	206628299	+	Silent	SNP	G	G	A													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagccacctgaagaaaaggtGacagccagagcgggggccag							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:206628299G>A	uc001hdy.2	+	18	2508	c.2175G>A	c.(2173-2175)GTG>GTA	p.V725V	SRGAP2_uc001hdx.2_Silent_p.V725V|SRGAP2_uc010pru.1_Silent_p.V648V	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	812					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					AAGAAAAGGTGACAGCCAGAG	0.552													0	0	0	0.003755	0	35	87										A	206628299	G	A	206628299	2	1	97	1	0	0	0	0	0	0	0	1	15145	1277	45	1		1	SRGAP2	1	206628299	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1315764	206628299	42622322	61	29549	150	2								
SRGAP2	23380	broad.mit.edu	37	chr1	206628307	206628307	+	Missense_Mutation	SNP	G	G	T													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgaagaaaaggtgacagccaGagcgggggccagctgtccca							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:206628307G>T	uc001hdy.2	+	18	2516	c.2183G>T	c.(2182-2184)AGA>ATA	p.R728I	SRGAP2_uc001hdx.2_Missense_Mutation_p.R728I|SRGAP2_uc010pru.1_Missense_Mutation_p.R651I	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	815					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					GTGACAGCCAGAGCGGGGGCC	0.537													1	0	1.58521e-26	0.005524	2.12543e-26	38	91										T	206628307	G	T	206628307	3	4	97	1	0	0	0	0	1	0	0	0	15145	942	33	3	2254	3	SRGAP2	1	206628307	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	8	206628307	42622314	62	29550	150	2								
TLR5	7100	broad.mit.edu	37	chr1	223285245	223285245	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caggaatttgaatgtttggtCttgaattattgcaatgtgat	10	3	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:223285245C>T	uc001hnv.1	-	4	1575	c.1129G>A	c.(1129-1131)GAC>AAC	p.D377N	TLR5_uc001hnw.1_Missense_Mutation_p.D377N	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	377	Extracellular (Potential).|LRR 8.				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		AATGTTTGGTCTTGAATTATT	0.368													0	0	0	0.00278	0	25	88										T	223285245	C	T	223285245	3	4	97	1	0	0	0	0	1	0	0	0	15951	913	32	1	1451	1	TLR5	1	223285245	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	16656938	223285245	25965376	63	29551										
C1orf69	200205	broad.mit.edu	37	chr1	228362831	228362831	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caatccctgcaggcgttcctGagggggtccgagacttgcct	13	13	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:228362831G>C	uc001hsl.3	+	3	777	c.688G>C	c.(688-690)GAG>CAG	p.E230Q	C1orf69_uc010pvw.1_Missense_Mutation_p.E37Q	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	230					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				AGGCGTTCCTGAGGGGGTCCG	0.627													0	0	0	0.007291	0	28	83										C	228362831	G	C	228362831	3	2	97	1	0	0	0	0	1	0	0	0	2057	1291	45	1	698	1	C1orf69	1	228362831	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5077586	228362831	20887790	64	29552										
TRIM67	440730	broad.mit.edu	37	chr1	231342533	231342533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgtcgtcctgcagacatccGatggtgagcatcgggatctc	12	12	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:231342533G>A	uc009xfn.1	+	7	1858	c.1816G>A	c.(1816-1818)GAT>AAT	p.D606N		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	606	B30.2/SPRY.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GCAGACATCCGATGGTGAGCA	0.502													0	0	0	0.00499	0	15	35										A	231342533	G	A	231342533	3	1	97	1	0	0	0	0	1	0	0	0	16537	1058	37	1	1842	1	TRIM67	1	231342533	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2979702	231342533	17908088	65	29553										
CNST	163882	broad.mit.edu	37	chr1	246810471	246810471	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgtctcggcacagagtcaaGtaaagaaagccaacatacag	9	9	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:246810471G>T	uc001ibp.2	+	9	1346	c.968G>T	c.(967-969)AGT>ATT	p.S323I	CNST_uc001ibo.3_Missense_Mutation_p.S323I	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	323					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						ACAGAGTCAAGTAAAGAAAGC	0.428											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.5548e-18	0.005443	2.03561e-18	24	85										T	246810471	G	T	246810471	3	4	97	1	0	0	0	0	1	0	0	0	3634	1029	36	4	998	4	CNST	1	246810471	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	15467938	246810471	2440150	66	29554										
OR2G2	81470	broad.mit.edu	37	chr1	247752379	247752379	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagctaccaggagacagaaaGcattcgggacctgcttctcc	10	13	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:247752379G>A	uc010pyy.1	+	1	718	c.718G>A	c.(718-720)GCA>ACA	p.A240T		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GAGACAGAAAGCATTCGGGAC	0.393													0	0	0	0.00632	0	28	93										A	247752379	G	A	247752379	3	1	97	1	0	0	0	0	1	0	0	0	10998	971	34	2	720	2	OR2G2	1	247752379	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	941908	247752379	1498242	67	29555										
OR2G3	81469	broad.mit.edu	37	chr1	247769738	247769738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctacaccatggtgacccccaCtttaaatcctatcatctata	3	14	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:247769738C>T	uc010pyz.1	+	1	851	c.851C>T	c.(850-852)ACT>ATT	p.T284I		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GTGACCCCCACTTTAAATCCT	0.433													0	0	0	0.005443	0	26	98										T	247769738	C	T	247769738	3	4	97	1	0	0	0	0	1	0	0	0	10999	565	20	2	853	2	OR2G3	1	247769738	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	17359	247769738	1480883	68	29556										
OR11L1	391189	broad.mit.edu	37	chr1	248004726	248004726	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggaaatcatcagggaaggcAgaaagcctgtgctgacccct	12	10	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:248004726A>T	uc001idn.1	-	1	473	c.473T>A	c.(472-474)CTG>CAG	p.L158Q		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CAGGGAAGGCAGAAAGCCTGT	0.577													0	0	0	0.002836	0	33	103										T	248004726	A	T	248004726	3	4	97	1	0	0	0	0	1	0	0	0	10930	188	7	5	499	5	OR11L1	1	248004726	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	234988	248004726	1245895	69	29557										
TRIM58	25893	broad.mit.edu	37	chr1	248020677	248020677	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcaggtgcatctccgagttCtgcgagaagtcggacggcgc	14	12	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr1:248020677C>T	uc001ido.2	+	1	177	c.129C>T	c.(127-129)TTC>TTT	p.F43F		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	43	RING-type.					intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TCTCCGAGTTCTGCGAGAAGT	0.711													0	0	0	0.00308	0	6	14										T	248020677	C	T	248020677	2	4	97	1	0	0	0	0	0	0	0	1	16528	912	32	1		1	TRIM58	1	248020677	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	15951	248020677	1229944	70	29558										
ZNF512	84450	broad.mit.edu	37	chr2	27821012	27821012	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gactccttaagtggttcatcGtctgcatcttcgtgtgaacc	9	11	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:27821012G>A	uc002rla.2	+	3	255	c.168G>A	c.(166-168)TCG>TCA	p.S56S	ZNF512_uc010ylv.1_5'UTR|ZNF512_uc010ylw.1_Silent_p.S55S|ZNF512_uc002rlb.2_5'UTR|ZNF512_uc010ylx.1_5'UTR|ZNF512_uc002rlc.2_5'UTR|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_5'UTR	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	56					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTGGTTCATCGTCTGCATCTT	0.408													0	0	0	0.003755	0	32	101										A	27821012	G	A	27821012	2	1	97	1	0	0	0	0	0	0	0	1	17953	1132	40	2		2	ZNF512	2	27821012	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		27821012	215378361	71	29559										
PLB1	151056	broad.mit.edu	37	chr2	28824168	28824168	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	catcacagtgctgatcggagGcagcgatttatgtgactact	11	9	1	2	rs146498076	byFrequency	TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:28824168G>T	uc002rmb.1	+	37	2576	c.2576G>T	c.(2575-2577)GGC>GTC	p.G859V	PLB1_uc010ezj.1_Missense_Mutation_p.G848V|PLB1_uc002rme.1_5'Flank	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	859	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|3.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CTGATCGGAGGCAGCGATTTA	0.453													1	0	6.21321e-17	0.00278	8.08029e-17	21	24										T	28824168	G	T	28824168	3	4	97	1	0	0	0	0	1	0	0	0	12024	1203	42	4	2755	4	PLB1	2	28824168	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1003156	28824168	214375205	72	29560										
BIRC6	57448	broad.mit.edu	37	chr2	32626450	32626450	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgggatgtttccaaacttatGaaggtatgtttgaattttga	10	3	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:32626450G>A	uc010ezu.2	+	7	1388	c.1254G>A	c.(1252-1254)ATG>ATA	p.M418I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	418					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CCAAACTTATGAAGGTATGTT	0.358													0	0	0	0.00361	0	148	133										A	32626450	G	A	32626450	3	1	97	1	0	0	0	0	1	0	0	0	1438	1290	45	1	1280	1	BIRC6	2	32626450	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3802282	32626450	210572923	73	29561										
BIRC6	57448	broad.mit.edu	37	chr2	32738069	32738069	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgaagagaagtggcaggatGaactacatgtgtcctaactc	11	7	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:32738069G>T	uc010ezu.2	+	54	10550	c.10416G>T	c.(10414-10416)ATG>ATT	p.M3472I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3472					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GTGGCAGGATGAACTACATGT	0.418													1	0	1.11015e-26	0.00361	1.49105e-26	54	45										T	32738069	G	T	32738069	3	4	97	1	0	0	0	0	1	0	0	0	1438	1290	45	3	10630	3	BIRC6	2	32738069	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	111619	32738069	210461304	74	29562										
BIRC6	57448	broad.mit.edu	37	chr2	32832589	32832589	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	taatgaaccgggatatgaacGgtctagaggcactcccagtg	12	9	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:32832589G>T	uc010ezu.2	+	72	14272	c.14138G>T	c.(14137-14139)CGG>CTG	p.R4713L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4713					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GGATATGAACGGTCTAGAGGC	0.423													1	0	6.93263e-47	0.00361	9.44146e-47	118	90										T	32832589	G	T	32832589	3	4	97	1	0	0	0	0	1	0	0	0	1438	1116	39	4	14424	4	BIRC6	2	32832589	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	94520	32832589	210366784	75	29563										
PLEKHH2	130271	broad.mit.edu	37	chr2	43989514	43989514	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaggatggtttaagcctcttAgaatacaactccatggtaag	10	7	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:43989514A>C	uc010yny.1	+	28	4226	c.4143A>C	c.(4141-4143)TTA>TTC	p.L1381F		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1381	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TAAGCCTCTTAGAATACAACT	0.368													0	0	0	0.00361	0	58	38										C	43989514	A	C	43989514	3	2	97	1	0	0	0	0	1	0	0	0	12077	417	15	5	4249	5	PLEKHH2	2	43989514	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	11156925	43989514	199209859	76	29564										
XPO1	7514	broad.mit.edu	37	chr2	61724137	61724137	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttcgaaacattggaacattCaggaactatttaaaaggggg	10	5	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:61724137C>T	uc002sbj.2	-	10	1493	c.765G>A	c.(763-765)CTG>CTA	p.L255L	XPO1_uc010fcl.2_Silent_p.L251L|XPO1_uc010ypn.1_Silent_p.L251L|XPO1_uc002sbk.2_5'UTR|XPO1_uc002sbh.2_5'Flank	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	255	Necessary for HTLV-1 Rex-mediated mRNA export.|HEAT 2.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding	p.L255L(1)		ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			TTGGAACATTCAGGAACTATT	0.348													0	0	0	0.00361	0	47	24										T	61724137	C	T	61724137	2	4	97	1	0	0	0	0	0	0	0	1	17442	813	29	1		1	XPO1	2	61724137	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	17734623	61724137	181475236	77	29565										
POLR1A	25885	broad.mit.edu	37	chr2	86325857	86325857	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcatgtggcagtttaaacaAgagccccgaagcagcaggta	12	9	0	1	rs36023304		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:86325857A>C	uc002sqs.2	-	3	688	c.309T>G	c.(307-309)TCT>TCG	p.S103S	POLR1A_uc002sqv.2_Silent_p.S103S	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	103					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGTTTAAACAAGAGCCCCGAA	0.498													0	0	0	0.00361	0	80	47										C	86325857	A	C	86325857	2	2	97	1	0	0	0	0	0	0	0	1	12209	59	3	5		5	POLR1A	2	86325857	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	24601720	86325857	156873516	78	29566										
CNNM3	26505	broad.mit.edu	37	chr2	97483118	97483118	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgctctacctcaaggacttGgccttcgtggatcccgaaga	10	12	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:97483118G>A	uc002swy.2	+	1	1128	c.1104G>A	c.(1102-1104)TTG>TTA	p.L368L	CNNM3_uc002swz.2_Silent_p.L368L	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	368	CBS 1.				ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						TCAAGGACTTGGCCTTCGTGG	0.602													0	0	0	0.00361	0	61	51										A	97483118	G	A	97483118	2	1	97	1	0	0	0	0	0	0	0	1	3614	1339	47	2		2	CNNM3	2	97483118	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	11157261	97483118	145716255	79	29567										
IL1F10	84639	broad.mit.edu	37	chr2	113832888	113832888	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcagccagtacagctcaccAaggagagtgagccctcagcc	11	14	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:113832888A>G	uc002tiu.2	+	5	481	c.406A>G	c.(406-408)AAG>GAG	p.K136E	IL1F10_uc002tiv.2_Missense_Mutation_p.K136E|IL1F10_uc002tiw.2_Missense_Mutation_p.K128E	NM_173161	NP_775184	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10	136						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			ovary(1)	1						ACAGCTCACCAAGGAGAGTGA	0.597													0	0	0	0.00361	0	93	68										G	113832888	A	G	113832888	3	3	97	1	0	0	0	0	1	0	0	0	7652	131	5	5	420	5	IL1F10	2	113832888	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	16349770	113832888	129366485	80	29568										
PTPN18	26469	broad.mit.edu	37	chr2	131127379	131127379	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaggacatcatgctcaggacCctcaaggtcacattccagaa	9	12	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:131127379C>T	uc002trc.2	+	7	626	c.525C>T	c.(523-525)ACC>ACT	p.T175T	PTPN18_uc002trd.2_Intron|PTPN18_uc002trb.2_Silent_p.T68T|PTPN18_uc002tre.2_5'Flank	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	175	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					TGCTCAGGACCCTCAAGGTCA	0.443													0	0	0	0.003755	0	33	27										T	131127379	C	T	131127379	2	4	97	1	0	0	0	0	0	0	0	1	12784	610	22	2		2	PTPN18	2	131127379	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	17294491	131127379	112071994	81	29569										
STAM2	10254	broad.mit.edu	37	chr2	152980445	152980445	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caccatgtgattgaactggaTatgtctattaatcagaaaga	8	6	2	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:152980445T>C	uc002tyc.3	-	13	1534	c.1184A>G	c.(1183-1185)TAT>TGT	p.Y395C		NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	395					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		TTGAACTGGATATGTCTATTA	0.358													0	0	0	0.00361	0	51	39										C	152980445	T	C	152980445	3	2	97	1	0	0	0	0	1	0	0	0	15248	1406	49	5	401	5	STAM2	2	152980445	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	21853066	152980445	90218928	82	29570										
KCNJ3	3760	broad.mit.edu	37	chr2	155555300	155555300	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttcgtattatgtctgcactcCgaaggaaatttggggacgat	11	7	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:155555300C>T	uc002tyv.1	+	1	208	c.13C>T	c.(13-15)CGA>TGA	p.R5*	KCNJ3_uc010zce.1_Nonsense_Mutation_p.R5*	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	5	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	GTCTGCACTCCGAAGGAAATT	0.602													0	0	0	0.00361	0	48	50										T	155555300	C	T	155555300	4	4	97	1	0	0	0	0	0	1	0	0	8052	644	23	2	15	2	KCNJ3	2	155555300	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2574855	155555300	87644073	83	29571										
BAZ2B	29994	broad.mit.edu	37	chr2	160245986	160245986	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cacgtttttcttgtttcaacCgctctttttccttaaaaaga	4	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:160245986C>A	uc002uao.2	-	21	3438	c.3086G>T	c.(3085-3087)CGG>CTG	p.R1029L	BAZ2B_uc002uap.2_Missense_Mutation_p.R993L	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1029	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTGTTTCAACCGCTCTTTTTC	0.294													1	0	0.00010058	0.001368	0.000122425	12	37										A	160245986	C	A	160245986	3	1	97	1	0	0	0	0	1	0	0	0	1332	652	23	4	3488	4	BAZ2B	2	160245986	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4690686	160245986	82953387	84	29572										
PDE11A	50940	broad.mit.edu	37	chr2	178936328	178936328	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atacctttgccccaggggacCtgcacctcatttgagttctc	8	14	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:178936328C>A	uc002ulq.2	-	1	1155	c.837G>T	c.(835-837)CAG>CAT	p.Q279H	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	279	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CCCAGGGGACCTGCACCTCAT	0.522									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				1	0	3.07327e-39	0.00361	4.16361e-39	91	81										A	178936328	C	A	178936328	3	1	97	1	0	0	0	0	1	0	0	0	11631	680	24	4	2044	4	PDE11A	2	178936328	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	18690342	178936328	64263045	85	29573										
TTN	7273	broad.mit.edu	37	chr2	179422610	179422610	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tacttaggtggctcccatttGagagtcacactttcttcagt	8	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:179422610G>T	uc010zfg.1	-	277	79991	c.79767C>A	c.(79765-79767)CTC>CTA	p.L26589L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L20284L|TTN_uc010zfi.1_Silent_p.L20217L|TTN_uc010zfj.1_Silent_p.L20092L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27516							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCCCATTTGAGAGTCACAC	0.428													1	0	7.99423e-63	0.00361	1.09446e-62	130	298										T	179422610	G	T	179422610	2	4	97	1	0	0	0	0	0	0	0	1	16732	1277	45	3		3	TTN	2	179422610	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	486282	179422610	63776763	86	29574										
RAPH1	65059	broad.mit.edu	37	chr2	204360028	204360028	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtcctgatcttccttgtcacTgtcttcttcagcaccatgat	6	13	5	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:204360028T>G	uc002vad.2	-	2	274	c.49A>C	c.(49-51)AGT>CGT	p.S17R	RAPH1_uc002vae.2_Missense_Mutation_p.S17R|RAPH1_uc002vaf.2_Missense_Mutation_p.S17R	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	17					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						TCCTTGTCACTGTCTTCTTCA	0.413													0	0	0	0.00361	0	73	64										G	204360028	T	G	204360028	3	3	97	1	0	0	0	0	1	0	0	0	13050	1580	55	5	3926	5	RAPH1	2	204360028	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	24937418	204360028	38839345	87	29575										
GPR1	2825	broad.mit.edu	37	chr2	207041473	207041473	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagggcaggaccgccaattaGagaagccaaaagccagatga	12	10	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:207041473G>C	uc002vbl.3	-	3	885	c.499C>G	c.(499-501)CTA>GTA	p.L167V	GPR1_uc010fue.2_Missense_Mutation_p.L167V|GPR1_uc010fuf.2_Missense_Mutation_p.L167V	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	167	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		CCGCCAATTAGAGAAGCCAAA	0.433													0	0	0	0.002096	0	33	35										C	207041473	G	C	207041473	3	2	97	1	0	0	0	0	1	0	0	0	6621	933	33	1	572	1	GPR1	2	207041473	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2681445	207041473	36157900	88	29576										
PRLH	51052	broad.mit.edu	37	chr2	238475309	238475309	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acccatcggcactccatggaGatccgcagtgagtgcctgga	12	13	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr2:238475309G>A	uc010znl.1	+	1	93	c.93G>A	c.(91-93)GAG>GAA	p.E31E		NM_015893	NP_056977	P81277	PRRP_HUMAN	prolactin releasing hormone precursor	31						extracellular region					0		Lung NSC(271;0.142)|all_lung(227;0.175)		Epithelial(121;8.28e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.03e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.19e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000329)|Lung(119;0.0106)|LUSC - Lung squamous cell carcinoma(224;0.0249)		ACTCCATGGAGATCCGCAGTG	0.652													0	0	0	0.004672	0	3	3										A	238475309	G	A	238475309	2	1	97	1	0	0	0	0	0	0	0	1	12529	933	33	1		1	PRLH	2	238475309	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	31433836	238475309	4724064	89	29577										
CHL1	10752	broad.mit.edu	37	chr3	367669	367669	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggttccaacaatcataaaacAgtcaaaagtccaagttgcct	6	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:367669A>T	uc003bou.2	+	4	390	c.119A>T	c.(118-120)CAG>CTG	p.Q40L	CHL1_uc003bot.2_Missense_Mutation_p.Q40L|CHL1_uc003bow.1_Missense_Mutation_p.Q40L|CHL1_uc011asi.1_Missense_Mutation_p.Q40L	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	40	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		ATCATAAAACAGTCAAAAGTC	0.338													0	0	0	0.000978	0	12	39										T	367669	A	T	367669	3	4	97	1	0	0	0	0	1	0	0	0	3349	188	7	5	125	5	CHL1	3	367669	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08		367669	197654761	90	29578										
LRRN1	57633	broad.mit.edu	37	chr3	3886380	3886380	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aattggtgctgggcctactaAtgacttcattaaccgagtct	9	9	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:3886380A>T	uc003bpt.3	+	2	816	c.55A>T	c.(55-57)ATG>TTG	p.M19L	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	19						integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		GGGCCTACTAATGACTTCATT	0.458													0	0	0	0.008361	0	31	63										T	3886380	A	T	3886380	3	4	97	1	0	0	0	0	1	0	0	0	9034	101	4	5	57	5	LRRN1	3	3886380	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	3518711	3886380	194136050	91	29579										
LRRN1	57633	broad.mit.edu	37	chr3	3886395	3886395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tactaatgacttcattaaccGagtcttccatacagaatagt	5	9	2	2	rs140162397		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:3886395G>A	uc003bpt.3	+	2	831	c.70G>A	c.(70-72)GAG>AAG	p.E24K	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	24						integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TTCATTAACCGAGTCTTCCAT	0.473													0	0	0	0.004289	0	37	69										A	3886395	G	A	3886395	3	1	97	1	0	0	0	0	1	0	0	0	9034	1059	37	1	72	1	LRRN1	3	3886395	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	15	3886395	194136035	92	29580										
NR1D2	9975	broad.mit.edu	37	chr3	24018855	24018855	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctaaagttgccagatcttcGatctttaaacaacatgcact	5	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:24018855G>T	uc003ccs.2	+	8	2004	c.1685G>T	c.(1684-1686)CGA>CTA	p.R562L	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.R487L	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	562					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						CCAGATCTTCGATCTTTAAAC	0.373													1	0	9.55421e-19	0.00361	1.25722e-18	47	108										T	24018855	G	T	24018855	3	4	97	1	0	0	0	0	1	0	0	0	10616	1058	37	3	1715	3	NR1D2	3	24018855	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	20132460	24018855	174003575	93	29581										
TGFBR2	7048	broad.mit.edu	37	chr3	30713456	30713457	+	Frame_Shift_Ins	INS	-	-	C													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctttgctgaggtctataaggINSccaagctgaagcagaacact							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:30713456_30713457insC	uc003ceo.2	+	4	1163_1164	c.781_782insC	c.(781-783)GCCfs	p.A261fs	TGFBR2_uc003cen.2_Frame_Shift_Ins_p.A286fs	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	261	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GGTCTATAAGGCCAAGCTGAAG	0.515																		50	62	---	---								C	30713457	-	C	30713456	7	5	97	1	0	1	1	0	0	0	0	0	15819	1203	42	0	874	0	TGFBR2	3	30713456	Frame_Shift_Ins	INS	-	TCGA-G2-A2ES-01A-11D-A17V-08	6694601	30713456	167308974	94	29582										
SCN11A	11280	broad.mit.edu	37	chr3	38962614	38962614	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tacagtccctcgagatgcatTtcaggttcagacttcccatg	8	12	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:38962614T>G	uc011ays.1	-	6	1044	c.845A>C	c.(844-846)AAA>ACA	p.K282T		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	282	I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CGAGATGCATTTCAGGTTCAG	0.443													0	0	0	0.00361	0	107	174										G	38962614	T	G	38962614	3	3	97	1	0	0	0	0	1	0	0	0	13913	1841	64	5	4614	5	SCN11A	3	38962614	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	8249158	38962614	159059816	95	29583										
COL7A1	1294	broad.mit.edu	37	chr3	48618755	48618755	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cccagggtctcccttctctcCaggaggccctgagtcaccct	9	18	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:48618755C>T	uc003ctz.2	-	51	4838	c.4837G>A	c.(4837-4839)GGA>AGA	p.G1613R	MIR711_hsa-mir-711|MI0012488_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1613	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCCTTCTCTCCAGGAGGCCCT	0.652													0	0	0	0.00499	0	16	31										T	48618755	C	T	48618755	3	4	97	1	0	0	0	0	1	0	0	0	3704	603	21	2	4269	2	COL7A1	3	48618755	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	9656141	48618755	149403675	96	29584										
DNAH1	25981	broad.mit.edu	37	chr3	52433606	52433607	+	Frame_Shift_Ins	INS	-	-	GGTGC													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aacacaaagaccccaagtagINSggtgctatatccatggatta							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:52433606_52433607insGGTGC	uc011bef.1	+	77	12748_12749	c.12487_12488insGGTGC	c.(12487-12489)GGGfs	p.G4163fs	DNAH1_uc003ddv.2_Intron	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	4228					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACCCCAAGTAGGGTGCTATATC	0.525																		7	39	---	---								GGTGC	52433607	-	GGTGC	52433606	7	5	97	1	0	1	1	0	0	0	0	0	4597	1000	35	0	12789	0	DNAH1	3	52433606	Frame_Shift_Ins	INS	-	TCGA-G2-A2ES-01A-11D-A17V-08	3814851	52433606	145588824	97	29585										
SPATA12	353324	broad.mit.edu	37	chr3	57107939	57107939	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccctcccagagctgacatttCagggggatgtgtgccaaagt	12	11	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:57107939C>T	uc003dij.1	+	2	892	c.217C>T	c.(217-219)CAG>TAG	p.Q73*	ARHGEF3_uc003dih.2_Intron	NM_181727	NP_859078	Q7Z6I5	SPT12_HUMAN	spermatogenesis associated 12	73											0				KIRC - Kidney renal clear cell carcinoma(284;0.0111)|Kidney(284;0.0129)		GCTGACATTTCAGGGGGATGT	0.532													0	0	0	0.001786	0	32	43										T	57107939	C	T	57107939	4	4	97	1	0	0	0	0	0	1	0	0	14998	827	29	1	219	1	SPATA12	3	57107939	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4674333	57107939	140914491	98	29586										
ABHD6	57406	broad.mit.edu	37	chr3	58255096	58255096	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcgtggacatgccaggacatGagggcaccacccgctcctcc	12	16	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:58255096G>A	uc003djs.3	+	4	735	c.325G>A	c.(325-327)GAG>AAG	p.E109K	ABHD6_uc003djr.2_Missense_Mutation_p.E109K|ABHD6_uc003djt.3_Missense_Mutation_p.E109K	NM_020676	NP_065727	Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	109	Cytoplasmic (Potential).					integral to membrane	acylglycerol lipase activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		GCCAGGACATGAGGGCACCAC	0.532													0	0	0	0.007413	0	13	31										A	58255096	G	A	58255096	3	1	97	1	0	0	0	0	1	0	0	0	86	1291	45	1	335	1	ABHD6	3	58255096	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1147157	58255096	139767334	99	29587										
C3orf67	200844	broad.mit.edu	37	chr3	58856020	58856020	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccgtgtaatacttgttcctCtgttaatgaactgatctgtt	7	8	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:58856020C>T	uc003dkt.1	-	8	765	c.356G>A	c.(355-357)AGA>AAA	p.R119K	C3orf67_uc003dks.1_5'Flank|uc003dku.1_Intron|C3orf67_uc003dkv.1_5'UTR|C3orf67_uc003dkw.2_Missense_Mutation_p.R27K	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	119											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		ACTTGTTCCTCTGTTAATGAA	0.378													0	0	0	0.008871	0	20	25										T	58856020	C	T	58856020	3	4	97	1	0	0	0	0	1	0	0	0	2241	913	32	1	1371	1	C3orf67	3	58856020	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	600924	58856020	139166410	100	29588										
OR5AC2	81050	broad.mit.edu	37	chr3	97806060	97806060	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gactcttgtgacagagtttgTtctcacaggacttacagatc	9	9	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:97806060T>G	uc011bgs.1	+	1	44	c.44T>G	c.(43-45)GTT>GGT	p.V15G		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACAGAGTTTGTTCTCACAGGA	0.403													0	0	0	0.00361	0	62	149										G	97806060	T	G	97806060	3	3	97	1	0	0	0	0	1	0	0	0	11141	1725	60	5	46	5	OR5AC2	3	97806060	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	38950040	97806060	100216370	101	29589										
TOMM70A	9868	broad.mit.edu	37	chr3	100103344	100103344	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttatatttttctttggctttCtcttttccaaggagtttaag	6	6	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:100103344C>T	uc003dtw.2	-	4	1146	c.714G>A	c.(712-714)GAG>GAA	p.E238E		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	238	Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						CTTTGGCTTTCTCTTTTCCAA	0.363													0	0	0	0.003271	0	33	86										T	100103344	C	T	100103344	2	4	97	1	0	0	0	0	0	0	0	1	16359	912	32	1		1	TOMM70A	3	100103344	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2297284	100103344	97919086	102	29590										
IMPG2	50939	broad.mit.edu	37	chr3	100961559	100961559	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cacatcaagagagtatttatCaatagccaagttcatggtat	7	7	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:100961559C>T	uc003duq.1	-	14	3198	c.2995G>A	c.(2995-2997)GAT>AAT	p.D999N	IMPG2_uc011bhe.1_Missense_Mutation_p.D862N	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	999	Extracellular (Potential).|SEA 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GAGTATTTATCAATAGCCAAG	0.398													0	0	0	0.002836	0	32	69										T	100961559	C	T	100961559	3	4	97	1	0	0	0	0	1	0	0	0	7729	826	29	1	754	1	IMPG2	3	100961559	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	858215	100961559	97060871	103	29591										
ABHD10	55347	broad.mit.edu	37	chr3	111697910	111697910	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcggggacaactacgaagaTggcggttgcgcgcttggcag	17	9	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:111697910T>G	uc003dyk.3	+	1	83	c.2T>G	c.(1-3)ATG>AGG	p.M1R	ABHD10_uc011bhq.1_5'UTR	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10 precursor	1						mitochondrion	serine-type peptidase activity				0						ACTACGAAGATGGCGGTTGCG	0.672													0	0	0	0.003163	0	12	49										G	111697910	T	G	111697910	3	3	97	1	0	0	0	0	1	0	0	0	74	1464	51	5	4	5	ABHD10	3	111697910	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	10736351	111697910	86324520	104	29592										
PARP14	54625	broad.mit.edu	37	chr3	122437771	122437771	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gccacagacacaaagggccaCagtttatctgttcagcgcct	9	13	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:122437771C>T	uc003efq.3	+	14	4832	c.4773C>T	c.(4771-4773)CAC>CAT	p.H1591H	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Silent_p.H1308H|PARP14_uc003efs.1_Silent_p.H1308H	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1591	WWE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CAAAGGGCCACAGTTTATCTG	0.393													0	0	0	0.00308	0	8	38										T	122437771	C	T	122437771	2	4	97	1	0	0	0	0	0	0	0	1	11458	477	17	2		2	PARP14	3	122437771	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10739861	122437771	75584659	105	29593										
MYLK	4638	broad.mit.edu	37	chr3	123367843	123367843	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	taatctctcctcaatgtcgtAgaagtcagatactttttgtt	6	8	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:123367843A>T	uc003ego.2	-	26	4672	c.4390T>A	c.(4390-4392)TAC>AAC	p.Y1464N	MYLK_uc010hrr.2_5'UTR|MYLK_uc011bjv.1_Missense_Mutation_p.Y264N|MYLK_uc011bjw.1_Missense_Mutation_p.Y1464N|MYLK_uc003egp.2_Missense_Mutation_p.Y1395N|MYLK_uc003egq.2_Missense_Mutation_p.Y1464N|MYLK_uc003egr.2_Missense_Mutation_p.Y1395N|MYLK_uc003egs.2_Missense_Mutation_p.Y1288N	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1464	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCAATGTCGTAGAAGTCAGAT	0.517													0	0	0	0.007291	0	28	114										T	123367843	A	T	123367843	3	4	97	1	0	0	0	0	1	0	0	0	10056	420	15	5	1390	5	MYLK	3	123367843	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	930072	123367843	74654587	106	29594										
PPP2R3A	5523	broad.mit.edu	37	chr3	135721464	135721464	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cattccaaacaactccacaaAttccttatataacttagagg	3	11	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:135721464A>T	uc003eqv.1	+	2	1689	c.1124A>T	c.(1123-1125)AAT>ATT	p.N375I	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	375					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						AACTCCACAAATTCCTTATAT	0.363													0	0	0	0.00333	0	25	67										T	135721464	A	T	135721464	3	4	97	1	0	0	0	0	1	0	0	0	12388	101	4	5	1126	5	PPP2R3A	3	135721464	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	12353621	135721464	62300966	107	29595										
TXNDC6	347736	broad.mit.edu	37	chr3	138024902	138024902	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcctctgtcatggttctctCttcatttgttagaatttcaa	6	9	6	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:138024902C>G	uc003esg.2	-	8	608	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Missense_Mutation_p.E109Q|TXNDC6_uc003ese.1_Missense_Mutation_p.E133Q	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	194	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						ATGGTTCTCTCTTCATTTGTT	0.373													0	0	0	0.002522	0	40	129										G	138024902	C	G	138024902	3	3	97	1	0	0	0	0	1	0	0	0	16797	922	32	1	410	1	TXNDC6	3	138024902	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2303438	138024902	59997528	108	29596										
TRIM42	287015	broad.mit.edu	37	chr3	140397361	140397361	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctatgagagccgctgctgccGcaataccatcatcactttcc	7	15	2	1	rs144112519		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:140397361G>A	uc003eto.1	+	1	481	c.290G>A	c.(289-291)CGC>CAC	p.R97H		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	97						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CGCTGCTGCCGCAATACCATC	0.542													0	0	0	0.00278	0	22	41										A	140397361	G	A	140397361	3	1	97	1	0	0	0	0	1	0	0	0	16514	1087	38	2	292	2	TRIM42	3	140397361	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2372459	140397361	57625069	109	29597										
XRN1	54464	broad.mit.edu	37	chr3	142140317	142140317	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caaaaatttctagttacttaCatctgatagtttcacaaggt	5	7	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:142140317C>T	uc003eus.2	-	9	1102	c.1035_splice	c.e9+1	p.D345_splice	XRN1_uc003eut.2_Splice_Site_p.D345_splice|XRN1_uc003euu.2_Splice_Site_p.D345_splice|XRN1_uc003euv.1_Splice_Site_p.D206_splice|XRN1_uc003euw.2_Splice_Site_p.D345_splice|XRN1_uc011bnh.1_Splice_Site_p.D135_splice	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TAGTTACTTACATCTGATAGT	0.318													0	0	0	0.001984	0	6	40										T	142140317	C	T	142140317	5	4	97	1	0	0	0	0	0	0	1	0	17456	492	17	2	4220	2	XRN1	3	142140317	Splice_Site	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1742956	142140317	55882113	110	29598										
PLOD2	5352	broad.mit.edu	37	chr3	145796998	145796998	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctctgatcggagtgtctttcCtttaattaagtacacattag	7	8	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:145796998C>T	uc003evs.1	-	13	1911	c.1405G>A	c.(1405-1407)GGA>AGA	p.G469R	PLOD2_uc003evq.1_Missense_Mutation_p.G129R|PLOD2_uc011bnm.1_Missense_Mutation_p.G414R|PLOD2_uc003evr.1_Missense_Mutation_p.G469R	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	469					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	AGTGTCTTTCCTTTAATTAAG	0.348													0	0	0	0.005443	0	29	53										T	145796998	C	T	145796998	3	4	97	1	0	0	0	0	1	0	0	0	12102	690	24	2	903	2	PLOD2	3	145796998	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3656681	145796998	52225432	111	29599										
HPS3	84343	broad.mit.edu	37	chr3	148863304	148863304	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aagtctcagcaggcagtactCacgccacaatttttgcacgt	8	12	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:148863304C>T	uc003ewu.1	+	5	1274	c.1134C>T	c.(1132-1134)CTC>CTT	p.L378L	HPS3_uc003ewt.1_Silent_p.L378L|HPS3_uc011bnq.1_Silent_p.L213L	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	378						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGGCAGTACTCACGCCACAAT	0.413									Hermansky-Pudlak_syndrome				0	0	0	0.00361	0	50	107										T	148863304	C	T	148863304	2	4	97	1	0	0	0	0	0	0	0	1	7340	813	29	1		1	HPS3	3	148863304	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3066306	148863304	49159126	112	29600										
MED12L	116931	broad.mit.edu	37	chr3	151102873	151102873	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caaagttcgacagttactacCtttgccgaaacagacatgtg	8	10	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:151102873C>T	uc003eyp.2	+	34	4915	c.4877C>T	c.(4876-4878)CCT>CTT	p.P1626L	MED12L_uc011bnz.1_Missense_Mutation_p.P1486L|P2RY12_uc011boa.1_5'Flank|P2RY12_uc003eyx.1_5'Flank|MED12L_uc003eyy.1_Missense_Mutation_p.P789L	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1626					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAGTTACTACCTTTGCCGAAA	0.388													0	0	0	0.00361	0	52	161										T	151102873	C	T	151102873	3	4	97	1	0	0	0	0	1	0	0	0	9429	681	24	2	5011	2	MED12L	3	151102873	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2239569	151102873	46919557	113	29601										
SGEF	26084	broad.mit.edu	37	chr3	153847391	153847391	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtcctgtatcaaaactacaaGgaaaaggcccttgacattga	8	9	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:153847391G>A	uc011bog.1	+	4	1363	c.1152G>A	c.(1150-1152)AAG>AAA	p.K384K	SGEF_uc011boh.1_Silent_p.K384K	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	384					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AAAACTACAAGGAAAAGGCCC	0.363													0	0	0	0.00308	0	7	16										A	153847391	G	A	153847391	2	1	97	1	0	0	0	0	0	0	0	1	14205	991	35	2		2	SGEF	3	153847391	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2744518	153847391	44175039	114	29602										
SLITRK3	22865	broad.mit.edu	37	chr3	164907052	164907052	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagggatgtgccagcaaaggCgtctgttggcagagtcctca	14	10	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:164907052C>G	uc003fej.3	-	2	2011	c.1567G>C	c.(1567-1569)GCC>CCC	p.A523P	SLITRK3_uc003fek.2_Missense_Mutation_p.A523P	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	523	LRR 11.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CCAGCAAAGGCGTCTGTTGGC	0.522										HNSCC(40;0.11)			0	0	0	0.007413	0	19	52										G	164907052	C	G	164907052	3	3	97	1	0	0	0	0	1	0	0	0	14744	768	27	4	1370	4	SLITRK3	3	164907052	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	11059661	164907052	33115378	115	29603										
CCDC39	339829	broad.mit.edu	37	chr3	180372711	180372711	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttaaccaaattttctttttCtctcgtttcctgctttatcc	2	11	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:180372711C>G	uc010hxe.2	-	7	884	c.769G>C	c.(769-771)GAA>CAA	p.E257Q	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	257	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTTTCTTTTTCTCTCGTTTCC	0.294													0	0	0	0.00308	0	8	30										G	180372711	C	G	180372711	3	3	97	1	0	0	0	0	1	0	0	0	2811	922	32	1	2112	1	CCDC39	3	180372711	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	15465659	180372711	17649719	116	29604										
CCDC39	339829	broad.mit.edu	37	chr3	180397161	180397161	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcagctcagccaggaattcgCtactcatgactgcaaacgga	10	12	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:180397161C>A	uc010hxe.2	-	1	123	c.8G>T	c.(7-9)AGC>ATC	p.S3I	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	3					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAGGAATTCGCTACTCATGAC	0.552													1	0	2.10328e-26	0.00361	2.81522e-26	73	194										A	180397161	C	A	180397161	3	1	97	1	0	0	0	0	1	0	0	0	2811	797	28	4	2897	4	CCDC39	3	180397161	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	24450	180397161	17625269	117	29605										
CCDC50	152137	broad.mit.edu	37	chr3	191098675	191098675	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttacaaaaaagccaaggagcGggagaaatcatctttggaca	10	7	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:191098675G>A	uc003fsw.2	+	8	1258	c.668G>A	c.(667-669)CGG>CAG	p.R223Q	CCDC50_uc003fsv.2_Missense_Mutation_p.R399Q	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	223	Lys-rich.					cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		GCCAAGGAGCGGGAGAAATCA	0.368													0	0	0	0.001855	0	12	20										A	191098675	G	A	191098675	3	1	97	1	0	0	0	0	1	0	0	0	2820	1116	39	2	1230	2	CCDC50	3	191098675	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	10701514	191098675	6923755	118	29606										
ZDHHC19	131540	broad.mit.edu	37	chr3	195935333	195935355	+	Frame_Shift_Del	DEL	GCCCGAGTAGAGGCACAGGGACA	GCCCGAGTAGAGGCACAGGGACA	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agacaggtgaccagcatggcGcccgagtagaggcacaggga					rs75505676	byFrequency	TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:195935333_195935355delGCCCGAGTAGAGGCACAGGGACA	uc003fwc.2	-	4	599_621	c.485_507delTGTCCCTGTGCCTCTACTCGGGC	c.(484-507)CTGTCCCTGTGCCTCTACTCGGGCfs	p.L162fs	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_RNA	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	162_169	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		CCAGCATGGCGCCCGAGTAGAGGCACAGGGACAGGACAAGCAG	0.583																		20	40	---	---								-	195935355	GCCCGAGTAGAGGCACAGGGACA	-	195935333	7	5	97	1	0	1	0	1	0	0	0	0	17606	1074	38	0	438	0	ZDHHC19	3	195935333	Frame_Shift_Del	DEL	GCCCGAGTAGAGGCACAGGGACA	TCGA-G2-A2ES-01A-11D-A17V-08	4836658	195935333	2087097	119	29607										
FYTTD1	84248	broad.mit.edu	37	chr3	197476889	197476889	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggagccacggcgacttcttCgccgccgccgaaggcccgca	14	17	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr3:197476889C>T	uc003fyi.2	+	1	266	c.47C>T	c.(46-48)TCG>TTG	p.S16L	KIAA0226_uc003fyd.3_5'Flank|KIAA0226_uc003fyf.2_5'Flank|FYTTD1_uc011bui.1_Intron|FYTTD1_uc011buj.1_RNA|FYTTD1_uc011buk.1_5'Flank	NM_032288	NP_115664	Q96QD9	UIF_HUMAN	forty-two-three domain containing 1 isoform 1	16					mRNA export from nucleus	nuclear speck	mRNA binding|protein binding				0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.175)		GCGACTTCTTCGCCGCCGCCG	0.652													0	0	0	0.004656	0	21	19										T	197476889	C	T	197476889	3	4	97	1	0	0	0	0	1	0	0	0	6127	893	31	1	49	1	FYTTD1	3	197476889	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1541556	197476889	545541	120	29608										
MFSD7	84179	broad.mit.edu	37	chr4	682809	682809	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttggagcagttgagcaggctGatcgcgagcaggaacaccca	14	10	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:682809G>A	uc003gay.2	-	1	165	c.108C>T	c.(106-108)ATC>ATT	p.I36I	MFSD7_uc003gax.2_Silent_p.I36I|MFSD7_uc003gaz.2_Silent_p.I36I|MFSD7_uc003gba.2_Silent_p.I36I|MFSD7_uc003gbb.1_5'Flank	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	36	Helical; (Potential).				transmembrane transport	integral to membrane					0						TGAGCAGGCTGATCGCGAGCA	0.721													0	0	0	0.00245	0	13	19										A	682809	G	A	682809	2	1	97	1	0	0	0	0	0	0	0	1	9537	1280	45	1		1	MFSD7	4	682809	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		682809	190471467	121	29609										
WHSC1	7468	broad.mit.edu	37	chr4	1957573	1957573	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgggtgaaacttgggaactAcaggtgtgagacatagaatc	13	5	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:1957573A>G	uc003gdz.3	+	14	2848	c.2672A>G	c.(2671-2673)TAC>TGC	p.Y891C	WHSC1_uc003geb.3_Missense_Mutation_p.Y891C|WHSC1_uc003gec.3_Missense_Mutation_p.Y891C|WHSC1_uc003ged.3_Missense_Mutation_p.Y891C|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.Y110C|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Missense_Mutation_p.Y239C	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	891	PWWP 2.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CTTGGGAACTACAGGTGTGAG	0.433			T	IGH@	MM								0	0	0	0.008361	0	30	47										G	1957573	A	G	1957573	3	3	97	1	0	0	0	0	1	0	0	0	17359	391	14	5	2798	5	WHSC1	4	1957573	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1274764	1957573	189196703	122	29610										
DOK7	285489	broad.mit.edu	37	chr4	3475151	3475151	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agactgcctgctgatgctggTctacaaggacaagtcggagc	13	10	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:3475151T>C	uc003ghd.2	+	3	189	c.119T>C	c.(118-120)GTC>GCC	p.V40A	DOK7_uc003ghe.2_5'UTR	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	40	PH.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CTGATGCTGGTCTACAAGGAC	0.687													0	0	0	0.004007	0	16	94										C	3475151	T	C	3475151	3	2	97	1	0	0	0	0	1	0	0	0	4702	1667	58	5	129	5	DOK7	4	3475151	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1517578	3475151	187679125	123	29611										
LDB2	9079	broad.mit.edu	37	chr4	16597444	16597444	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaatgtaatacaggtcggtcAcccctccttcaaacacagtg	8	12	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:16597444A>C	uc003goz.2	-	3	606	c.290T>G	c.(289-291)GTG>GGG	p.V97G	LDB2_uc003gpa.2_Missense_Mutation_p.V97G|LDB2_uc003gpb.2_Missense_Mutation_p.V97G|LDB2_uc011bxh.1_Missense_Mutation_p.V97G|LDB2_uc010iee.2_Missense_Mutation_p.V97G|LDB2_uc003goy.2_5'UTR|LDB2_uc011bxi.1_5'UTR	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	97							LIM domain binding|transcription cofactor activity				0						CAGGTCGGTCACCCCTCCTTC	0.493													0	0	0	0.004482	0	5	63										C	16597444	A	C	16597444	3	2	97	1	0	0	0	0	1	0	0	0	8696	159	6	5	964	5	LDB2	4	16597444	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	13122293	16597444	174556832	124	29612										
PDS5A	23244	broad.mit.edu	37	chr4	39850583	39850583	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagccacatcacatactgtaTacagtttctagggaggaaaa	9	8	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:39850583T>C	uc003guv.3	-	28	3767	c.3227A>G	c.(3226-3228)TAT>TGT	p.Y1076C	PDS5A_uc010ifo.2_Missense_Mutation_p.Y1036C	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1076					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						ACATACTGTATACAGTTTCTA	0.313													0	0	0	0.001168	0	6	25										C	39850583	T	C	39850583	3	2	97	1	0	0	0	0	1	0	0	0	11691	1406	49	5	810	5	PDS5A	4	39850583	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	23253139	39850583	151303693	125	29613										
GNPDA2	132789	broad.mit.edu	37	chr4	44709782	44709782	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgctcacctttaaagtatttCacagttttaactcttaattc	3	9	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:44709782C>T	uc003gwy.2	-	6	913	c.756G>A	c.(754-756)GTG>GTA	p.V252V	GNPDA2_uc010iga.2_Silent_p.V218V|GNPDA2_uc011bzb.1_Silent_p.V182V|GNPDA2_uc003gwz.1_Silent_p.V252V	NM_138335	NP_612208	Q8TDQ7	GNPI2_HUMAN	glucosamine-6-phosphate deaminase 2	252					N-acetylglucosamine metabolic process	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity			ovary(1)	1						TAAAGTATTTCACAGTTTTAA	0.388													0	0	0	0.001368	0	10	21										T	44709782	C	T	44709782	2	4	97	1	0	0	0	0	0	0	0	1	6543	813	29	1		1	GNPDA2	4	44709782	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4859199	44709782	146444494	126	29614										
FRYL	285527	broad.mit.edu	37	chr4	48578237	48578237	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctttcttagcattgatggggCtactaaggaaaaaaaaagaa	9	5	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:48578237C>T	uc003gyh.1	-	24	3136	c.2531G>A	c.(2530-2532)AGC>AAC	p.S844N	FRYL_uc003gyk.2_Missense_Mutation_p.S844N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	844					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						ATTGATGGGGCTACTAAGGAA	0.323													0	0	0	0.00278	0	20	65										T	48578237	C	T	48578237	3	4	97	1	0	0	0	0	1	0	0	0	6064	797	28	2	6674	2	FRYL	4	48578237	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3868455	48578237	142576039	127	29615										
AASDH	132949	broad.mit.edu	37	chr4	57215543	57215543	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtcaactgccttcattctatGagaatgggaaccaatgtaca	8	9	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:57215543G>T	uc003hbn.2	-	11	2527	c.2374C>A	c.(2374-2376)CAT>AAT	p.H792N	AASDH_uc010ihb.2_Missense_Mutation_p.H307N|AASDH_uc011caa.1_Missense_Mutation_p.H639N|AASDH_uc003hbo.2_Missense_Mutation_p.H692N|AASDH_uc011cab.1_Missense_Mutation_p.H307N|AASDH_uc010ihc.2_Missense_Mutation_p.H792N|AASDH_uc003hbp.2_Missense_Mutation_p.H792N	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	792					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TTCATTCTATGAGAATGGGAA	0.418													1	0	1.88708e-17	0.008361	2.45826e-17	31	112										T	57215543	G	T	57215543	3	4	97	1	0	0	0	0	1	0	0	0	22	1290	45	3	942	3	AASDH	4	57215543	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	8637306	57215543	133938733	128	29616										
C4orf14	84273	broad.mit.edu	37	chr4	57842717	57842743	+	In_Frame_Del	DEL	GCCCACTAAGTAGACGTCCCCACGGTA	GCCCACTAAGTAGACGTCCCCACGGTA	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gatttgccggcgttggtggcGcccactaagtagacgtcccc					rs145154138		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:57842717_57842743delGCCCACTAAGTAGACGTCCCCACGGTA	uc003hck.2	-	1	1084_1110	c.1009_1035delTACCGTGGGGACGTCTACTTAGTGGGC	c.(1009-1035)TACCGTGGGGACGTCTACTTAGTGGGCdel	p.YRGDVYLVG337del	POLR2B_uc003hcl.1_5'Flank|POLR2B_uc011cae.1_5'Flank|POLR2B_uc011caf.1_5'Flank	NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	337_345							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					CGTTGGTGGCGCCCACTAAGTAGACGTCCCCACGGTAGCGCCAGGAG	0.612																		9	87	---	---								-	57842743	GCCCACTAAGTAGACGTCCCCACGGTA	-	57842717	7	5	97	1	0	1	0	1	0	0	0	0	2251	1074	38	0	1089	0	C4orf14	4	57842717	In_Frame_Del	DEL	GCCCACTAAGTAGACGTCCCCACGGTA	TCGA-G2-A2ES-01A-11D-A17V-08	627174	57842717	133311559	129	29617										
YTHDC1	91746	broad.mit.edu	37	chr4	69196015	69196015	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcttctcatttacagggagcGtggaccatacaccctacata	7	12	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:69196015G>A	uc003hdx.2	-	8	1489	c.1136C>T	c.(1135-1137)ACG>ATG	p.T379M	YTHDC1_uc003hdy.2_Missense_Mutation_p.T361M	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	379	YTH.									upper_aerodigestive_tract(1)|ovary(1)	2						TACAGGGAGCGTGGACCATAC	0.318													0	0	0	0.003163	0	13	26										A	69196015	G	A	69196015	3	1	97	1	0	0	0	0	1	0	0	0	17493	1145	40	2	1087	2	YTHDC1	4	69196015	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	11353298	69196015	121958261	130	29618										
AMBN	258	broad.mit.edu	37	chr4	71459051	71459051	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aattatgttttagattccacTtttcaaaatgaaggacctga	6	6	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:71459051T>C	uc003hfl.2	+	2	98	c.23T>C	c.(22-24)CTT>CCT	p.L8P		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	8					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TAGATTCCACTTTTCAAAATG	0.353													0	0	0	0.001855	0	12	83										C	71459051	T	C	71459051	3	2	97	1	0	0	0	0	1	0	0	0	563	1609	56	5	29	5	AMBN	4	71459051	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	2263036	71459051	119695225	131	29619										
AMBN	258	broad.mit.edu	37	chr4	71459067	71459067	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccacttttcaaaatgaaggaCctgatactgatcctatgcct	6	11	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:71459067C>T	uc003hfl.2	+	2	114	c.39C>T	c.(37-39)GAC>GAT	p.D13D		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	13					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			AAATGAAGGACCTGATACTGA	0.343													0	0	0	0.001523	0	17	98										T	71459067	C	T	71459067	2	4	97	1	0	0	0	0	0	0	0	1	563	506	18	2		2	AMBN	4	71459067	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	16	71459067	119695209	132	29620										
FRAS1	80144	broad.mit.edu	37	chr4	79367924	79367924	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gatgaccttgcagcccctcaGagtgcagctgagctcgggag	14	12	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:79367924G>A	uc003hlb.2	+	43	6340	c.5900G>A	c.(5899-5901)AGA>AAA	p.R1967K		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1966	CSPG 8.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CAGCCCCTCAGAGTGCAGCTG	0.433													0	0	0	0.001855	0	13	25										A	79367924	G	A	79367924	3	1	97	1	0	0	0	0	1	0	0	0	6042	942	33	1	6145	1	FRAS1	4	79367924	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	7908857	79367924	111786352	133	29621										
PRDM8	56978	broad.mit.edu	37	chr4	81123531	81123531	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagctgagtcccgacggcatCgccacgggcggcggcaaagg	17	13	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:81123531C>T	uc010ijo.2	+	8	1754	c.915C>T	c.(913-915)ATC>ATT	p.I305I	PRDM8_uc003hmb.3_Silent_p.I305I|PRDM8_uc003hmc.3_Silent_p.I305I	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	305	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCGACGGCATCGCCACGGGCG	0.607											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	17										T	81123531	C	T	81123531	2	4	97	1	0	0	0	0	0	0	0	1	12462	874	31	1		1	PRDM8	4	81123531	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1755607	81123531	110030745	134	29622										
HNRNPD	3184	broad.mit.edu	37	chr4	83280703	83280703	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgataggatctaacttcagaGtgcagtctacaacttcacca	7	10	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:83280703G>A	uc003hmm.1	-	3	698	c.380C>T	c.(379-381)ACT>ATT	p.T127I	HNRNPD_uc003hml.1_RNA|HNRNPD_uc003hmn.1_Missense_Mutation_p.T108I|HNRNPD_uc003hmo.1_Missense_Mutation_p.T127I|HNRNPD_uc003hmp.1_Missense_Mutation_p.T108I|HNRNPD_uc010ijr.1_Missense_Mutation_p.T108I|HNRNPD_uc011cci.1_Intron	NM_031370	NP_112738	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D	127	RRM 1.				nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding				0						TAACTTCAGAGTGCAGTCTAC	0.408													0	0	0	0.00632	0	28	84										A	83280703	G	A	83280703	3	1	97	1	0	0	0	0	1	0	0	0	7264	1029	36	2	711	2	HNRNPD	4	83280703	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2157172	83280703	107873573	135	29623										
SEC31A	22872	broad.mit.edu	37	chr4	83778203	83778203	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caatataatggcatcggccaTgcggttatcatgtaaacaaa	8	8	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:83778203T>C	uc003hnf.2	-	16	1947	c.1783A>G	c.(1783-1785)ATG>GTG	p.M595V	SEC31A_uc003hne.2_Missense_Mutation_p.M328V|SEC31A_uc011ccl.1_Missense_Mutation_p.M556V|SEC31A_uc003hnl.2_Missense_Mutation_p.M556V|SEC31A_uc003hng.2_Missense_Mutation_p.M595V|SEC31A_uc003hnh.2_Missense_Mutation_p.M595V|SEC31A_uc003hni.2_Missense_Mutation_p.M595V|SEC31A_uc003hnj.2_Missense_Mutation_p.M556V|SEC31A_uc011ccm.1_Missense_Mutation_p.M590V|SEC31A_uc011ccn.1_Missense_Mutation_p.M595V|SEC31A_uc003hnk.2_Missense_Mutation_p.M556V|SEC31A_uc003hnm.2_Missense_Mutation_p.M595V|SEC31A_uc003hnn.1_Missense_Mutation_p.M595V	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	595					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GCATCGGCCATGCGGTTATCA	0.418													0	0	0	0.001882	0	23	61										C	83778203	T	C	83778203	3	2	97	1	0	0	0	0	1	0	0	0	13998	1464	51	5	1927	5	SEC31A	4	83778203	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	497500	83778203	107376073	136	29624										
HELQ	113510	broad.mit.edu	37	chr4	84364763	84364763	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcataccaataatttgagtCgtttctaaaacacaaacaaa	3	9	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:84364763C>T	uc003hom.2	-	6	1649	c.1470G>A	c.(1468-1470)ACG>ACA	p.T490T	HELQ_uc010ikb.2_Silent_p.T423T|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_Intron	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	490	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						TAATTTGAGTCGTTTCTAAAA	0.289								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.00245	0	15	30										T	84364763	C	T	84364763	2	4	97	1	0	0	0	0	0	0	0	1	7047	871	31	1		1	HELQ	4	84364763	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	586560	84364763	106789513	137	29625										
WDFY3	23001	broad.mit.edu	37	chr4	85687004	85687004	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tagttaagacagaatctgtcTgttcaagccatcctccacca	6	12	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:85687004T>A	uc003hpd.2	-	32	5555	c.5147A>T	c.(5146-5148)CAG>CTG	p.Q1716L		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1716						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGAATCTGTCTGTTCAAGCCA	0.378													0	0	0	0.002299	0	22	79										A	85687004	T	A	85687004	3	1	97	1	0	0	0	0	1	0	0	0	17267	1580	55	5	5581	5	WDFY3	4	85687004	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1322241	85687004	105467272	138	29626										
SLC10A6	345274	broad.mit.edu	37	chr4	87770173	87770173	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtggacaccactgtgaaaacGagctccaggtttccatgcac	10	12	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:87770173G>A	uc003hqd.2	-	1	244	c.96C>T	c.(94-96)CTC>CTT	p.L32L		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	32	Helical; (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		CTGTGAAAACGAGCTCCAGGT	0.562													0	0	0	0.00278	0	24	61										A	87770173	G	A	87770173	2	1	97	1	0	0	0	0	0	0	0	1	14378	1045	37	1		1	SLC10A6	4	87770173	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2083169	87770173	103384103	139	29627										
PPP3CA	5530	broad.mit.edu	37	chr4	102267947	102267947	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggatcaattgccttgggctCggacatctccagctgccgga	13	12	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:102267947C>T	uc011cen.1	-	1	682	c.7G>A	c.(7-9)GAG>AAG	p.E3K	PPP3CA_uc003hvu.2_Missense_Mutation_p.E3K|PPP3CA_uc010ilj.2_Missense_Mutation_p.E3K|PPP3CA_uc003hvt.2_5'UTR|PPP3CA_uc003hvs.2_Missense_Mutation_p.E3K|PPP3CA_uc010ilk.2_Missense_Mutation_p.E3K|uc003hvw.2_5'Flank	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	3	Catalytic.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		GCCTTGGGCTCGGACATCTCC	0.637													0	0	0	0.008291	0	10	33										T	102267947	C	T	102267947	3	4	97	1	0	0	0	0	1	0	0	0	12397	893	31	1	1614	1	PPP3CA	4	102267947	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	14497774	102267947	88886329	140	29628										
CENPE	1062	broad.mit.edu	37	chr4	104066984	104066984	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	catggtgaaagatgaaacctActttagctacaatttctttt	6	7	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:104066984A>T	uc003hxb.1	-	30	4503	c.4413_splice	c.e30+1	p.K1471_splice	CENPE_uc003hxc.1_Splice_Site_p.K1446_splice	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GATGAAACCTACTTTAGCTAC	0.308													0	0	0	0.006122	0	19	51										T	104066984	A	T	104066984	5	4	97	1	0	0	0	0	0	0	1	0	3230	405	14	5	3770	5	CENPE	4	104066984	Splice_Site	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1799037	104066984	87087292	141	29629										
PITX2	5308	broad.mit.edu	37	chr4	111539518	111539518	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttcaagttattcaggctgttGagactggagcccgggacgcc	13	10	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:111539518G>A	uc003iad.2	-	5	1299	c.717C>T	c.(715-717)CTC>CTT	p.L239L	PITX2_uc003iac.2_Silent_p.L246L|PITX2_uc003iae.2_Silent_p.L193L|PITX2_uc010iml.2_Silent_p.L110L|PITX2_uc003iaf.2_Silent_p.L239L	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	239					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		TCAGGCTGTTGAGACTGGAGC	0.582													0	0	0	0.00333	0	24	65										A	111539518	G	A	111539518	2	1	97	1	0	0	0	0	0	0	0	1	11955	1277	45	1		1	PITX2	4	111539518	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	7472534	111539518	79614758	142	29630										
PRDM5	11107	broad.mit.edu	37	chr4	121843681	121843681	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggtcacccacctttcgcactCtgcgggccgtgtagagcccc	11	17	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:121843681C>T	uc003idn.2	-	1	333	c.83G>A	c.(82-84)AGA>AAA	p.R28K	PRDM5_uc003ido.2_Missense_Mutation_p.R28K|PRDM5_uc010ine.2_Missense_Mutation_p.R28K|PRDM5_uc010inf.2_Missense_Mutation_p.R28K|PRDM5_uc003idp.1_Missense_Mutation_p.R28K	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	28	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						CTTTCGCACTCTGCGGGCCGT	0.672													0	0	0	0.003163	0	11	32										T	121843681	C	T	121843681	3	4	97	1	0	0	0	0	1	0	0	0	12460	913	32	1	1873	1	PRDM5	4	121843681	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10304163	121843681	69310595	143	29631										
QRFPR	84109	broad.mit.edu	37	chr4	122250851	122250851	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcttgattgtgacatcatcaTattccttttcaaaattacct	3	9	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:122250851T>A	uc010inj.1	-	6	1293	c.914A>T	c.(913-915)TAT>TTT	p.Y305F	QRFPR_uc010ink.1_RNA|QRFPR_uc003ids.2_3'UTR	NM_198179	NP_937822	Q96P65	QRFPR_HUMAN	G protein-coupled receptor 103	305	Extracellular (Potential).					plasma membrane	neuropeptide Y receptor activity				0						GACATCATCATATTCCTTTTC	0.289													0	0	0	0.00308	0	8	10										A	122250851	T	A	122250851	3	1	97	1	0	0	0	0	1	0	0	0	12878	1406	49	5	385	5	QRFPR	4	122250851	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	407170	122250851	68903425	144	29632										
FAT4	79633	broad.mit.edu	37	chr4	126370445	126370445	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctcagagtacttcagtaaaAgtcatgattaacattttaga	6	6	3	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:126370445A>C	uc003ifj.3	+	9	8274	c.8274A>C	c.(8272-8274)AAA>AAC	p.K2758N	FAT4_uc011cgp.1_Missense_Mutation_p.K1056N|FAT4_uc003ifi.1_Missense_Mutation_p.K236N	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2758	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTTCAGTAAAAGTCATGATTA	0.378													0	0	0	0.00632	0	29	109										C	126370445	A	C	126370445	3	2	97	1	0	0	0	0	1	0	0	0	5692	69	3	5	8308	5	FAT4	4	126370445	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	4119594	126370445	64783831	145	29633										
HSPA4L	22824	broad.mit.edu	37	chr4	128751844	128751844	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaatggaaaaggttgaaaaaTgtatcagtgatgccatgagt	11	3	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:128751844T>C	uc003ifm.2	+	18	2471	c.2218T>C	c.(2218-2220)TGT>CGT	p.C740R	HSPA4L_uc011cgr.1_Missense_Mutation_p.C707R	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	740					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GGTTGAAAAATGTATCAGTGA	0.343													0	0	0	0.007413	0	18	32										C	128751844	T	C	128751844	3	2	97	1	0	0	0	0	1	0	0	0	7413	1464	51	5	2288	5	HSPA4L	4	128751844	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	2381399	128751844	62402432	146	29634										
ABCE1	6059	broad.mit.edu	37	chr4	146046206	146046206	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgaaattacattcagaagaGatccaaacaactataggcca	6	8	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:146046206G>A	uc003ijx.2	+	17	2145	c.1705G>A	c.(1705-1707)GAT>AAT	p.D569N	ABCE1_uc003ijy.2_Missense_Mutation_p.D569N|ABCE1_uc010iot.2_RNA	NM_001040876	NP_001035809	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E, member 1	569					interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			skin(1)	1	all_hematologic(180;0.151)					ATTCAGAAGAGATCCAAACAA	0.294													0	0	0	0.001882	0	16	83										A	146046206	G	A	146046206	3	1	97	1	0	0	0	0	1	0	0	0	64	942	33	1	1767	1	ABCE1	4	146046206	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	17294362	146046206	45108070	147	29635										
LRBA	987	broad.mit.edu	37	chr4	151223937	151223937	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggccaaacaccacttggatCaatcttcctgtaatgcaaaa	6	11	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:151223937C>T	uc010ipj.2	-	54	8364	c.7890G>A	c.(7888-7890)TTG>TTA	p.L2630L	LRBA_uc010ipi.2_Silent_p.L152L|LRBA_uc003ils.3_Silent_p.L525L|LRBA_uc003ilt.3_Silent_p.L1278L|LRBA_uc003ilu.3_Silent_p.L2619L|LRBA_uc003ilr.3_Silent_p.L50L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2630	WD 2.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CCACTTGGATCAATCTTCCTG	0.363													0	0	0	0.007413	0	18	70										T	151223937	C	T	151223937	2	4	97	1	0	0	0	0	0	0	0	1	8931	825	29	1		1	LRBA	4	151223937	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5177731	151223937	39930339	148	29636										
FBXW7	55294	broad.mit.edu	37	chr4	153245449	153245450	+	Frame_Shift_Ins	INS	-	-	G													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cattccacttgttaacgactINSggtgccctgttaacgtgtga							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:153245449_153245450insG	uc003ims.2	-	11	1890_1891	c.1741_1742insC	c.(1741-1743)CAGfs	p.Q581fs	FBXW7_uc011cii.1_Frame_Shift_Ins_p.Q581fs|FBXW7_uc003imt.2_Frame_Shift_Ins_p.Q581fs|FBXW7_uc011cih.1_Frame_Shift_Ins_p.Q405fs|FBXW7_uc003imq.2_Frame_Shift_Ins_p.Q501fs|FBXW7_uc003imr.2_Frame_Shift_Ins_p.Q463fs	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	581	WD 6.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.G579_Q581>E(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGTTAACGACTGGTGCCCTGTT	0.416			Mis|N|D|F		colorectal|endometrial|T-ALL													12	56	---	---								G	153245450	-	G	153245449	7	5	97	1	0	1	1	0	0	0	0	0	5769	1580	55	0	389	0	FBXW7	4	153245449	Frame_Shift_Ins	INS	-	TCGA-G2-A2ES-01A-11D-A17V-08	2021512	153245449	37908827	149	29637										
FBXW7	55294	broad.mit.edu	37	chr4	153250906	153250906	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	taccacaaaactgtaagcatGtgatcacatgatcatcatgt	6	9	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:153250906G>T	uc003ims.2	-	8	1303	c.1154C>A	c.(1153-1155)ACA>AAA	p.T385K	FBXW7_uc011cii.1_Missense_Mutation_p.T385K|FBXW7_uc003imt.2_Missense_Mutation_p.T385K|FBXW7_uc011cih.1_Missense_Mutation_p.T209K|FBXW7_uc003imq.2_Missense_Mutation_p.T305K|FBXW7_uc003imr.2_Missense_Mutation_p.T267K	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	385	WD 1.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTGTAAGCATGTGATCACATG	0.343			Mis|N|D|F		colorectal|endometrial|T-ALL								1	0	2.37509e-13	0.001523	3.05818e-13	20	92										T	153250906	G	T	153250906	3	4	97	1	0	0	0	0	1	0	0	0	5769	1377	48	4	989	4	FBXW7	4	153250906	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5457	153250906	37903370	150	29638										
TRIM2	23321	broad.mit.edu	37	chr4	154243942	154243942	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agtcaccaggtttggtagccGaggaaatggggacaggcagt	16	7	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:154243942G>A	uc003ing.2	+	9	2045	c.1844G>A	c.(1843-1845)CGA>CAA	p.R615Q	TRIM2_uc003inh.2_Missense_Mutation_p.R642Q	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	615	NHL 4.					cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		TTTGGTAGCCGAGGAAATGGG	0.473													0	0	0	0.002299	0	22	47										A	154243942	G	A	154243942	3	1	97	1	0	0	0	0	1	0	0	0	16491	1058	37	1	1959	1	TRIM2	4	154243942	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	993036	154243942	36910334	151	29639										
TRIM2	23321	broad.mit.edu	37	chr4	154243969	154243969	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggggacaggcagtttgcagGtacactcgatggtaatatgt	14	6	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:154243969G>A	uc003ing.2	+	9	2071	c.1870_splice	c.e9+1	p.G624_splice	TRIM2_uc003inh.2_Splice_Site_p.G651_splice	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2							cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CAGTTTGCAGGTACACTCGAT	0.473													0	0	0	0.005443	0	25	35										A	154243969	G	A	154243969	5	1	97	1	0	0	0	0	0	0	1	0	16491	1275	44	2	1986	2	TRIM2	4	154243969	Splice_Site	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	27	154243969	36910307	152	29640										
RBM46	166863	broad.mit.edu	37	chr4	155749131	155749131	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaggccttattcttatccagGctatcctttgtcaccaacaa	5	12	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:155749131G>A	uc003ioo.2	+	5	1687	c.1514G>A	c.(1513-1515)GGC>GAC	p.G505D	RBM46_uc011cim.1_3'UTR|RBM46_uc003iop.1_3'UTR	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	505							nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				TCTTATCCAGGCTATCCTTTG	0.453													0	0	0	0.00361	0	59	176										A	155749131	G	A	155749131	3	1	97	1	0	0	0	0	1	0	0	0	13140	1203	42	2	1528	2	RBM46	4	155749131	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1505162	155749131	35405145	153	29641										
NPY5R	4889	broad.mit.edu	37	chr4	164272420	164272420	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atccagtaagttcataccagGggtccccacttgctttgaga	9	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:164272420G>A	uc003iqn.2	+	4	1177	c.995G>A	c.(994-996)GGG>GAG	p.G332E		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	332	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				TTCATACCAGGGGTCCCCACT	0.398													0	0	0	0.00245	0	12	58										A	164272420	G	A	164272420	3	1	97	1	0	0	0	0	1	0	0	0	10610	1232	43	2	997	2	NPY5R	4	164272420	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	8523289	164272420	26881856	154	29642										
PALLD	23022	broad.mit.edu	37	chr4	169819719	169819719	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tagaaaggtctcctgtggatGaatcaggtgatgaagttcag	13	5	3	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:169819719G>A	uc011cjx.1	+	14	2537	c.2326G>A	c.(2326-2328)GAA>AAA	p.E776K	CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Missense_Mutation_p.E759K|PALLD_uc003irv.2_Missense_Mutation_p.E377K|PALLD_uc003irw.2_Missense_Mutation_p.E261K|PALLD_uc003irx.2_5'UTR	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	983					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		TCCTGTGGATGAATCAGGTGA	0.408									Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.000978	0	12	57										A	169819719	G	A	169819719	3	1	97	1	0	0	0	0	1	0	0	0	11407	1291	45	1	2883	1	PALLD	4	169819719	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5547299	169819719	21334557	155	29643										
UFSP2	55325	broad.mit.edu	37	chr4	186324770	186324770	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgtgtgggccaaaactcctcCccctatagaagaaaaaatag	8	10	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr4:186324770C>T	uc003ixo.2	-	11	1318	c.1201G>A	c.(1201-1203)GGA>AGA	p.G401R	UFSP2_uc003ixn.2_Missense_Mutation_p.G276R|UFSP2_uc003ixq.2_Missense_Mutation_p.G291R|UFSP2_uc003ixp.2_RNA	NM_018359	NP_060829	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	401						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity				0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		AAAACTCCTCCCCCTATAGAA	0.338													0	0	0	0.007413	0	19	63										T	186324770	C	T	186324770	3	4	97	1	0	0	0	0	1	0	0	0	16935	632	22	2	216	2	UFSP2	4	186324770	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	16505051	186324770	4829506	156	29644										
FASTKD3	79072	broad.mit.edu	37	chr5	7867567	7867567	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgcgaacttccatgccaccTtttctgagacgattttggca	8	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:7867567T>C	uc003jeb.2	-	2	767	c.630A>G	c.(628-630)AAA>AAG	p.K210K	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	210					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						CCATGCCACCTTTTCTGAGAC	0.433													0	0	0	0.002522	0	45	96										C	7867567	T	C	7867567	2	2	97	1	0	0	0	0	0	0	0	1	5687	1606	56	5		5	FASTKD3	5	7867567	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08		7867567	173047693	157	29645										
CDH10	1008	broad.mit.edu	37	chr5	24492973	24492973	+	Frame_Shift_Del	DEL	A	A	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gattgacagcagctaaactgAaaaaaaatttctgtccacct							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:24492973delA	uc003jgr.1	-	10	1909	c.1577delT	c.(1576-1578)TTCfs	p.F526fs	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	526	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)								10	399	---	---								-	24492973	A	-	24492973	7	5	97	1	0	1	0	1	0	0	0	0	3096	246	9	0	801	0	CDH10	5	24492973	Frame_Shift_Del	DEL	A	TCGA-G2-A2ES-01A-11D-A17V-08	16625406	24492973	156422287	158	29646										
PDZD2	23037	broad.mit.edu	37	chr5	32059441	32059441	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccttgctccaggatcagtggCcaagatggagagcaacctga	12	11	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:32059441C>A	uc003jhl.2	+	13	2685	c.2297C>A	c.(2296-2298)GCC>GAC	p.A766D	PDZD2_uc003jhm.2_Missense_Mutation_p.A766D|PDZD2_uc011cnx.1_Missense_Mutation_p.A592D	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	766	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGATCAGTGGCCAAGATGGAG	0.448													1	0	6.49762e-13	0.006122	8.3114e-13	17	43										A	32059441	C	A	32059441	3	1	97	1	0	0	0	0	1	0	0	0	11701	739	26	4	2343	4	PDZD2	5	32059441	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	7566468	32059441	148855819	159	29647										
RAI14	26064	broad.mit.edu	37	chr5	34821857	34821857	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtgctgatagcttattggatAtaagttctgaagctgaccaa	10	6	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:34821857A>G	uc003jir.2	+	14	1211	c.1015A>G	c.(1015-1017)ATA>GTA	p.I339V	RAI14_uc010iur.2_Missense_Mutation_p.I310V|RAI14_uc011coj.1_Missense_Mutation_p.I339V|RAI14_uc010ius.1_Missense_Mutation_p.I268V|RAI14_uc003jis.2_Missense_Mutation_p.I342V|RAI14_uc003jit.2_Missense_Mutation_p.I339V|RAI14_uc011cok.1_Missense_Mutation_p.I331V	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	339						cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CTTATTGGATATAAGTTCTGA	0.348													0	0	0	0.00278	0	22	97										G	34821857	A	G	34821857	3	3	97	1	0	0	0	0	1	0	0	0	13008	449	16	5	1130	5	RAI14	5	34821857	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2762416	34821857	146093403	160	29648										
NIPBL	25836	broad.mit.edu	37	chr5	37059268	37059268	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctttgtggattttctgatagGtaaggttacataagcagtga	11	4	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:37059268G>A	uc003jkl.3	+	44	8184	c.7685_splice	c.e44+1	p.S2562_splice	NIPBL_uc003jkk.3_Splice_Site_p.S2562_splice|NIPBL_uc003jkn.2_Splice_Site_p.S255_splice	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTTCTGATAGGTAAGGTTACA	0.244													0	0	0	0.00499	0	18	77										A	37059268	G	A	37059268	5	1	97	1	0	0	0	0	0	0	1	0	10428	1275	44	2	7856	2	NIPBL	5	37059268	Splice_Site	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2237411	37059268	143855992	161	29649										
C9	735	broad.mit.edu	37	chr5	39341658	39341658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aattcaagcacaaagattacCtgtactgcattgaaagtcat	6	8	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:39341658C>T	uc003jlv.3	-	3	417	c.328G>A	c.(328-330)GGC>AGC	p.G110S		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	110	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CAAAGATTACCTGTACTGCAT	0.463													0	0	0	0.00278	0	20	86										T	39341658	C	T	39341658	3	4	97	1	0	0	0	0	1	0	0	0	2443	695	24	2	1387	2	C9	5	39341658	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2282390	39341658	141573602	162	29650										
HEATR7B2	133558	broad.mit.edu	37	chr5	41009477	41009477	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cccactggaggctggcttttCagccagcgccttccacaatg	10	15	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:41009477C>T	uc003jmj.3	-	32	3815	c.3325G>A	c.(3325-3327)GAA>AAA	p.E1109K	HEATR7B2_uc003jmi.3_Missense_Mutation_p.E664K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1109							binding			ovary(6)|central_nervous_system(2)	8						GCTGGCTTTTCAGCCAGCGCC	0.498													0	0	0	0.00361	0	49	121										T	41009477	C	T	41009477	3	4	97	1	0	0	0	0	1	0	0	0	7035	835	29	1	1476	1	HEATR7B2	5	41009477	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1667819	41009477	139905783	163	29651										
PARP8	79668	broad.mit.edu	37	chr5	50090057	50090057	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acagaatcatgcagacatttGttacacagcagtggaaacag	9	8	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:50090057G>A	uc003jon.3	+	12	936	c.754G>A	c.(754-756)GTT>ATT	p.V252I	PARP8_uc011cpz.1_Missense_Mutation_p.V144I|PARP8_uc003joo.2_Missense_Mutation_p.V252I|PARP8_uc003jop.2_Missense_Mutation_p.V252I	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	252						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GCAGACATTTGTTACACAGCA	0.343													0	0	0	0.001855	0	13	48										A	50090057	G	A	50090057	3	1	97	1	0	0	0	0	1	0	0	0	11465	1377	48	2	796	2	PARP8	5	50090057	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	9080580	50090057	130825203	164	29652										
CDC20B	166979	broad.mit.edu	37	chr5	54436170	54436170	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acacattcggattgctcacaGagctgcatttttccattagc	7	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:54436170G>C	uc003jpo.1	-	5	727	c.552C>G	c.(550-552)CTC>CTG	p.L184L	CDC20B_uc003jpn.1_Silent_p.L184L|CDC20B_uc010ivu.1_Silent_p.L184L|CDC20B_uc010ivv.1_Silent_p.L184L|CDC20B_uc003jpp.2_RNA	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	184											0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			ATTGCTCACAGAGCTGCATTT	0.408													0	0	0	0.008871	0	18	38										C	54436170	G	C	54436170	2	2	97	1	0	0	0	0	0	0	0	1	3060	929	33	1		1	CDC20B	5	54436170	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4346113	54436170	126479090	165	29653										
ARSB	411	broad.mit.edu	37	chr5	78280775	78280775	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgtacctggtagcggccagtGagcagctggctccgcgacgg	16	13	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:78280775G>A	uc003kfq.2	-	1	1583	c.297C>T	c.(295-297)CTC>CTT	p.L99L	ARSB_uc003kfr.3_Silent_p.L99L	NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	99					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		AGCGGCCAGTGAGCAGCTGGC	0.512													0	0	0	0.000602	0	5	10										A	78280775	G	A	78280775	2	1	97	1	0	0	0	0	0	0	0	1	988	1277	45	1		1	ARSB	5	78280775	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	23844605	78280775	102634485	166	29654										
ZFYVE16	9765	broad.mit.edu	37	chr5	79733327	79733327	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	catgtggattactaaaagatGttggcttagtaaaagaggaa	11	3	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:79733327G>T	uc003kgr.3	+	4	1125	c.823G>T	c.(823-825)GTT>TTT	p.V275F	ZFYVE16_uc010jak.1_Missense_Mutation_p.V275F|ZFYVE16_uc003kgp.2_Missense_Mutation_p.V275F|ZFYVE16_uc003kgq.3_Missense_Mutation_p.V275F|ZFYVE16_uc003kgs.3_Missense_Mutation_p.V275F	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	275					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		ACTAAAAGATGTTGGCTTAGT	0.418													1	0	6.00712e-18	0.002445	7.83844e-18	32	82										T	79733327	G	T	79733327	3	4	97	1	0	0	0	0	1	0	0	0	17661	1377	48	4	829	4	ZFYVE16	5	79733327	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1452552	79733327	101181933	167	29655										
GPR98	84059	broad.mit.edu	37	chr5	90086879	90086879	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agggaggagccgaactggatCtggagaagagtatcacatgg	16	6	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:90086879C>A	uc003kju.2	+	70	14329	c.14233C>A	c.(14233-14235)CTG>ATG	p.L4745M	GPR98_uc003kjt.2_Missense_Mutation_p.L2451M|GPR98_uc003kjw.2_Missense_Mutation_p.L406M	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4745	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CGAACTGGATCTGGAGAAGAG	0.443													1	0	3.08376e-08	0.00333	3.83134e-08	25	58										A	90086879	C	A	90086879	3	1	97	1	0	0	0	0	1	0	0	0	6721	912	32	3	14511	3	GPR98	5	90086879	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10353552	90086879	90828381	168	29656										
MCTP1	79772	broad.mit.edu	37	chr5	94245027	94245027	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcaatgactcctcctctttcTtcataaaggtgaaaatcaaa	4	10	5	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:94245027T>C	uc003kkx.2	-	10	1581	c.1581A>G	c.(1579-1581)GAA>GAG	p.E527E	MCTP1_uc003kkv.2_Silent_p.E306E|MCTP1_uc003kkw.2_Silent_p.E260E|MCTP1_uc003kkz.2_Silent_p.E188E|MCTP1_uc003kku.2_Silent_p.E43E	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	527	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CTCCTCTTTCTTCATAAAGGT	0.368													0	0	0	0.006122	0	19	70										C	94245027	T	C	94245027	2	2	97	1	0	0	0	0	0	0	0	1	9400	1606	56	5		5	MCTP1	5	94245027	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	4158148	94245027	86670233	169	29657										
CHD1	1105	broad.mit.edu	37	chr5	98240643	98240643	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggttttgcttgaactttgttTtctcgggaagtgtctgactc	11	7	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:98240643T>G	uc003knf.2	-	2	361	c.213A>C	c.(211-213)GAA>GAC	p.E71D		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	71					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GAACTTTGTTTTCTCGGGAAG	0.433													0	0	0	0.00361	0	65	98										G	98240643	T	G	98240643	3	3	97	1	0	0	0	0	1	0	0	0	3323	1838	64	5	5055	5	CHD1	5	98240643	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	3995616	98240643	82674617	170	29658										
SLC25A46	91137	broad.mit.edu	37	chr5	110097170	110097170	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgttggatgcttattttccAgaacttattgctaactttgc	7	7	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:110097170A>T	uc003koz.2	+	8	1012	c.945A>T	c.(943-945)CCA>CCT	p.P315P	SLC25A46_uc011cvi.1_Silent_p.P224P	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	315	Solcar 2.|Helical; Name=5; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		CTTATTTTCCAGAACTTATTG	0.413													0	0	0	0.00361	0	86	215										T	110097170	A	T	110097170	2	4	97	1	0	0	0	0	0	0	0	1	14511	175	7	5		5	SLC25A46	5	110097170	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	11856527	110097170	70818090	171	29659										
EPB41L4A	64097	broad.mit.edu	37	chr5	111506035	111506035	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aatctcttttaattgttcttCggacaatccggatggatcca	7	9	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:111506035C>T	uc003kpv.1	-	20	1976	c.1702G>A	c.(1702-1704)GAA>AAA	p.E568K	EPB41L4A_uc003kpp.1_Missense_Mutation_p.E195K|EPB41L4A_uc003kpu.1_5'Flank	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	568						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		AATTGTTCTTCGGACAATCCG	0.363													0	0	0	0.001855	0	11	37										T	111506035	C	T	111506035	3	4	97	1	0	0	0	0	1	0	0	0	5155	893	31	1	374	1	EPB41L4A	5	111506035	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1408865	111506035	69409225	172	29660										
YTHDC2	64848	broad.mit.edu	37	chr5	112903525	112903525	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gattggcaagtaatgctcttCaggaaccttcatcctttaga	8	9	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:112903525C>T	uc003kqn.2	+	23	3406	c.3223C>T	c.(3223-3225)CAG>TAG	p.Q1075*		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1075							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TAATGCTCTTCAGGAACCTTC	0.318													0	0	0	0.00361	0	40	79										T	112903525	C	T	112903525	4	4	97	1	0	0	0	0	0	1	0	0	17494	827	29	1	3313	1	YTHDC2	5	112903525	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1397490	112903525	68011735	173	29661										
ACSL6	23305	broad.mit.edu	37	chr5	131310491	131310491	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgtgtgctaaaggcaaatagGaaatgtgcacatccgcacaa	10	8	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:131310491G>T	uc010jdo.1	-	11	1036	c.953C>A	c.(952-954)TCC>TAC	p.S318Y	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.S343Y|ACSL6_uc003kvy.1_Intron|ACSL6_uc003kwb.2_Missense_Mutation_p.S308Y|ACSL6_uc003kvz.1_Intron|ACSL6_uc003kwa.1_Intron|ACSL6_uc003kvw.1_5'Flank|ACSL6_uc010jdn.1_Intron|ACSL6_uc010jdp.1_Intron	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	318	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGCAAATAGGAAATGTGCAC	0.542													1	0	0.00621372	0.006214	0.00750463	10	23										T	131310491	G	T	131310491	3	4	97	1	0	0	0	0	1	0	0	0	181	1174	41	3	1184	3	ACSL6	5	131310491	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	18406966	131310491	49604769	174	29662										
SLC22A4	6583	broad.mit.edu	37	chr5	131630518	131630518	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caacaacagtgtcccgctgcGgctgcgggacggccgcgagg	16	14	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:131630518G>A	uc003kwq.2	+	1	374	c.209G>A	c.(208-210)CGG>CAG	p.R70Q	uc003kwm.3_Intron|SLC22A4_uc010jdq.1_5'Flank	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	solute carrier family 22 member 4	70	Extracellular (Potential).				body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|carnitine transporter activity|cation:cation antiporter activity|PDZ domain binding|secondary active organic cation transmembrane transporter activity|symporter activity				0		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	GTCCCGCTGCGGCTGCGGGAC	0.726													0	0	0	0.001368	0	13	21										A	131630518	G	A	131630518	3	1	97	1	0	0	0	0	1	0	0	0	14456	1116	39	2	211	2	SLC22A4	5	131630518	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	320027	131630518	49284742	175	29663										
GDF9	2661	broad.mit.edu	37	chr5	132197956	132197956	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaatttatagacatgtgaatActtctcttgttggaggccac	8	7	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:132197956A>G	uc003kxz.1	-	2	942	c.690T>C	c.(688-690)AGT>AGC	p.S230S	GDF9_uc011cxj.1_Silent_p.S142S	NM_005260	NP_005251	O60383	GDF9_HUMAN	growth differentiation factor 9 precursor	230					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			skin(1)	1		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACATGTGAATACTTCTCTTGT	0.408													0	0	0	0.008361	0	31	62										G	132197956	A	G	132197956	2	3	97	1	0	0	0	0	0	0	0	1	6319	388	14	5		5	GDF9	5	132197956	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	567438	132197956	48717304	176	29664										
AFF4	27125	broad.mit.edu	37	chr5	132223808	132223808	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccaatgcatctgcattgtgcTttagcttttttgcttcttgt	7	9	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:132223808T>A	uc003kyd.2	-	15	3185	c.2777A>T	c.(2776-2778)AAG>ATG	p.K926M	AFF4_uc011cxk.1_Missense_Mutation_p.K604M	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	926					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCATTGTGCTTTAGCTTTTT	0.274													0	0	0	0.00245	0	14	36										A	132223808	T	A	132223808	3	1	97	1	0	0	0	0	1	0	0	0	359	1609	56	5	742	5	AFF4	5	132223808	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	25852	132223808	48691452	177	29665										
C5orf15	56951	broad.mit.edu	37	chr5	133295523	133295523	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcttcctcttgagacagagGagtaggcgagggatgaggga	17	6	1	3	rs11540542		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:133295523G>A	uc003kyo.2	-	2	459	c.328C>T	c.(328-330)CCT>TCT	p.P110S		NM_020199	NP_064584	Q8NC54	KCT2_HUMAN	keratinocytes associated transmembrane protein 2	110	Extracellular (Potential).					integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TGAGACAGAGGAGTAGGCGAG	0.493													0	0	0	0.006214	0	8	34										A	133295523	G	A	133295523	3	1	97	1	0	0	0	0	1	0	0	0	2283	1174	41	1	477	1	C5orf15	5	133295523	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1071715	133295523	47619737	178	29666										
CDC25C	995	broad.mit.edu	37	chr5	137622194	137622194	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttagacactcacattcggggGcccctctctgaggagaattc	10	12	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:137622194G>A	uc003lcp.1	-	12	1423	c.1152C>T	c.(1150-1152)GGC>GGT	p.G384G	CDC25C_uc003lcq.1_Silent_p.G311G|CDC25C_uc003lcr.1_Silent_p.G384G|CDC25C_uc011cyp.1_Silent_p.G401G|CDC25C_uc003lcs.1_Silent_p.G462G	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	384	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACATTCGGGGGCCCCTCTCTG	0.478													0	0	0	0.002222	0	43	97										A	137622194	G	A	137622194	2	1	97	1	0	0	0	0	0	0	0	1	3064	1190	42	2		2	CDC25C	5	137622194	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4326671	137622194	43293066	179	29667										
PCDHA6	56142	broad.mit.edu	37	chr5	140209996	140209996	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggatctcatggcctttagcCccagcctttcaccttgtcct	7	15	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:140209996C>T	uc003lho.2	+	1	2347	c.2320C>T	c.(2320-2322)CCC>TCC	p.P774S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.P774S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	774	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCTTTAGCCCCAGCCTTTC	0.517													0	0	0	0.006999	0	34	75										T	140209996	C	T	140209996	3	4	97	1	0	0	0	0	1	0	0	0	11528	623	22	2	2322	2	PCDHA6	5	140209996	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2587802	140209996	40705264	180	29668										
SLC36A2	153201	broad.mit.edu	37	chr5	150701700	150701700	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggcaaaggggatgatgatttCtgcagggacgtagaactgca	15	6	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:150701700C>T	uc003lty.2	-	9	1217	c.1087G>A	c.(1087-1089)GAA>AAA	p.E363K	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.E165K|SLC36A2_uc010jhv.2_Missense_Mutation_p.E363K	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	363	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGATGATTTCTGCAGGGACG	0.552													0	0	0	0.00333	0	25	63										T	150701700	C	T	150701700	3	4	97	1	0	0	0	0	1	0	0	0	14594	922	32	1	372	1	SLC36A2	5	150701700	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10491704	150701700	30213560	181	29669										
FAT2	2196	broad.mit.edu	37	chr5	150931089	150931089	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcaagttatagttcgaccttCtcctggtatcaagaggcctg	9	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:150931089C>T	uc003lue.3	-	6	4248	c.4235G>A	c.(4234-4236)AGA>AAA	p.R1412K	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1412	Extracellular (Potential).|Cadherin 12.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTCGACCTTCTCCTGGTATC	0.537													0	0	0	0.002096	0	33	64										T	150931089	C	T	150931089	3	4	97	1	0	0	0	0	1	0	0	0	5690	913	32	1	8886	1	FAT2	5	150931089	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	229389	150931089	29984171	182	29670										
PTTG1	9232	broad.mit.edu	37	chr5	159849713	159849715	+	Splice_Site	DEL	CAG	CAG	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttatggtaagactttttcttCagcaatcaaagccttagatg							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:159849713_159849715delCAG	uc003lyj.2	+	3	137	c.92_splice	c.e3-1	p.S31_splice	PTTG1_uc003lyk.2_Splice_Site_p.S31_splice	NM_004219	NP_004210	O95997	PTTG1_HUMAN	pituitary tumor-transforming protein 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)		ACTTTTTCTTCAGCAATCAAAGC	0.424																		20	94	---	---								-	159849715	CAG	-	159849713	8	5	97	1	0	1	0	1	0	0	1	0	12819	841	29	0		0	PTTG1	5	159849713	Splice_Site	DEL	CAG	TCGA-G2-A2ES-01A-11D-A17V-08	8918624	159849713	21065547	183	29671										
C5orf41	153222	broad.mit.edu	37	chr5	172518250	172518250	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actaaatgcagtcctgaagaAgatgaggaggacgaggagga	15	5	0	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:172518250A>T	uc003mch.2	+	4	1372	c.1068A>T	c.(1066-1068)GAA>GAT	p.E356D	C5orf41_uc003mcg.2_Missense_Mutation_p.E356D|C5orf41_uc003mcf.2_Missense_Mutation_p.E356D|C5orf41_uc011dfd.1_Missense_Mutation_p.E356D	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	356	Glu-rich.						protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GTCCtgaagaagatgaggagg	0.194													0	0	0	0.008291	0	9	24										T	172518250	A	T	172518250	3	4	97	1	0	0	0	0	1	0	0	0	2300	69	3	5	1078	5	C5orf41	5	172518250	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	12668537	172518250	8397010	184	29672										
C5orf25	375484	broad.mit.edu	37	chr5	175717546	175717546	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggcatgccacacttaccggGagatgtgttacattcacctg	11	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr5:175717546G>A	uc003mds.3	+	4	1369	c.962G>A	c.(961-963)GGA>GAA	p.G321E	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Missense_Mutation_p.G340E|uc003mdu.1_Missense_Mutation_p.G232E			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	321	Pro-rich.										0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		CACTTACCGGGAGATGTGTTA	0.547													0	0	0	0.001855	0	8	183										A	175717546	G	A	175717546	3	1	97	1	0	0	0	0	1	0	0	0	2288	1189	41	1		1	C5orf25	5	175717546	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3199296	175717546	5197714	185	29673										
OR2J3	442186	broad.mit.edu	37	chr6	29080151	29080151	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gttttaccaactcagcacttCattcctccttcaccttctgg	4	15	4	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:29080151C>A	uc011dll.1	+	1	484	c.484C>A	c.(484-486)CAT>AAT	p.H162N		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTCAGCACTTCATTCCTCCTT	0.488													1	0	2.40789e-81	0.00361	3.30237e-81	158	143										A	29080151	C	A	29080151	3	1	97	1	0	0	0	0	1	0	0	0	11004	826	29	3	486	3	OR2J3	6	29080151	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08		29080151	142034916	186	29674										
RPL10A	4736	broad.mit.edu	37	chr6	35438423	35438423	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgagcttgtgtataacattCacctggctgtcaacttcttg	8	9	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:35438423C>T	uc003okp.1	+	6	584	c.550C>T	c.(550-552)CAC>TAC	p.H184Y	RPL10A_uc003okq.1_Missense_Mutation_p.H100Y|RPL10A_uc003okr.1_Missense_Mutation_p.H100Y|RPL10A_uc003oks.1_Missense_Mutation_p.H100Y	NM_007104	NP_009035	P62906	RL10A_HUMAN	ribosomal protein L10a	184					anatomical structure morphogenesis|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	RNA binding|structural constituent of ribosome			ovary(1)	1						GTATAACATTCACCTGGCTGT	0.493													0	0	0	0.003214	0	45	50										T	35438423	C	T	35438423	3	4	97	1	0	0	0	0	1	0	0	0	13555	826	29	1	572	1	RPL10A	6	35438423	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	6358272	35438423	135676644	187	29675										
DNAH8	1769	broad.mit.edu	37	chr6	38942237	38942237	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaattaatcaagaccttctgGacatcagtaatttacccatg	6	9	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:38942237G>C	uc003ooe.1	+	83	12715	c.12115G>C	c.(12115-12117)GAC>CAC	p.D4039H	DNAH8_uc003oog.1_Missense_Mutation_p.D488H	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGACCTTCTGGACATCAGTAA	0.423													0	0	0	0.002445	0	32	78										C	38942237	G	C	38942237	3	2	97	1	0	0	0	0	1	0	0	0	4607	1174	41	1	12437	1	DNAH8	6	38942237	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3503814	38942237	132172830	188	29676										
KIF6	221458	broad.mit.edu	37	chr6	39507798	39507798	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cctattttcttgtggagcaaActggatcttttccccaaaat	6	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:39507798A>T	uc003oot.2	-	13	1721	c.1626T>A	c.(1624-1626)AGT>AGA	p.S542R	KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Missense_Mutation_p.S333R|KIF6_uc011dua.1_Missense_Mutation_p.S542R|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	542					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TGTGGAGCAAACTGGATCTTT	0.443													0	0	0	0.00361	0	123	117										T	39507798	A	T	39507798	3	4	97	1	0	0	0	0	1	0	0	0	8308	40	2	5	862	5	KIF6	6	39507798	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	565561	39507798	131607269	189	29677										
LMBRD1	55788	broad.mit.edu	37	chr6	70386122	70386122	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actccttcaataaccgatttCttccctttacaacaggatac	3	13	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:70386122C>T	uc003pfa.2	-	16	1666	c.1551G>A	c.(1549-1551)AAG>AAA	p.K517K	LMBRD1_uc003pey.2_Silent_p.K313K|LMBRD1_uc003pez.2_Silent_p.K444K|LMBRD1_uc010kal.2_Silent_p.K444K|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	517	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						TAACCGATTTCTTCCCTTTAC	0.313													0	0	0	0.001855	0	11	31										T	70386122	C	T	70386122	2	4	97	1	0	0	0	0	0	0	0	1	8842	912	32	1		1	LMBRD1	6	70386122	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	30878324	70386122	100728945	190	29678										
OR2A4	79541	broad.mit.edu	37	chr6	132021851	132021851	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaaggctttcctctgaacttCccttgattggatctgaagga	10	9	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:132021851C>T	uc011ecd.1	-	1	691	c.691G>A	c.(691-693)GAA>AAA	p.E231K	ENPP3_uc003qcu.3_Intron|ENPP3_uc010kfq.2_Intron|ENPP3_uc003qcv.2_Intron	NM_030908	NP_112170	O95047	OR2A4_HUMAN	olfactory receptor, family 2, subfamily A,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.018)|OV - Ovarian serous cystadenocarcinoma(155;0.041)		CTCTGAACTTCCCTTGATTGG	0.493													0	0	0	0.002522	0	35	82										T	132021851	C	T	132021851	3	4	97	1	0	0	0	0	1	0	0	0	10979	864	30	1	244	1	OR2A4	6	132021851	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	61635729	132021851	39093216	191	29679										
ECT2L	345930	broad.mit.edu	37	chr6	139164270	139164270	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggctgctgctacttatgggaCgctgaatgaacccaaaacag	11	10	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:139164270C>T	uc003qif.1	+	4	600	c.497C>T	c.(496-498)ACG>ATG	p.T166M	ECT2L_uc011edq.1_Missense_Mutation_p.T97M	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	166					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						ACTTATGGGACGCTGAATGAA	0.458													0	0	0	0.006999	0	40	52										T	139164270	C	T	139164270	3	4	97	1	0	0	0	0	1	0	0	0	4902	536	19	2	511	2	ECT2L	6	139164270	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	7142419	139164270	31950797	192	29680										
C6orf97	80129	broad.mit.edu	37	chr6	151857488	151857488	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctttcggaagtcccggtcacGcgggagcagttaaaccacta	11	12	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:151857488G>T	uc003qol.2	+	2	182	c.93G>T	c.(91-93)ACG>ACT	p.T31T		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	31	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		TCCCGGTCACGCGGGAGCAGT	0.428													1	0	7.92952e-12	0.003954	1.01098e-11	23	34										T	151857488	G	T	151857488	2	4	97	1	0	0	0	0	0	0	0	1	2374	1074	38	4		4	C6orf97	6	151857488	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	12693218	151857488	19257579	193	29681										
LPA	4018	broad.mit.edu	37	chr6	160953592	160953592	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtcagtgcctctggccaaatGctcagcacaaatatacttat	7	11	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr6:160953592G>C	uc003qtl.2	-	39	6052	c.5932C>G	c.(5932-5934)CAT>GAT	p.H1978D		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4486	Peptidase S1.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CTGGCCAAATGCTCAGCACAA	0.458													0	0	0	0.001523	0	22	43										C	160953592	G	C	160953592	3	2	97	1	0	0	0	0	1	0	0	0	8903	1319	46	4	198	4	LPA	6	160953592	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	9096104	160953592	10161475	194	29682										
TNRC18	84629	broad.mit.edu	37	chr7	5354756	5354756	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcgcttggcacttggcaccaGaagggccggggacggctcag	17	12	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:5354756G>C	uc003soi.3	-	26	7235	c.6886C>G	c.(6886-6888)CTG>GTG	p.L2296V		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2296							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CTTGGCACCAGAAGGGCCGGG	0.667													0	0	0	0.006214	0	8	19										C	5354756	G	C	5354756	3	2	97	1	0	0	0	0	1	0	0	0	16336	933	33	1	2040	1	TNRC18	7	5354756	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		5354756	153783907	195	29683										
ARL4A	10124	broad.mit.edu	37	chr7	12728009	12728009	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tatacaggctgcagttcaatGaatttgtaaataccgtacct	7	8	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:12728009G>C	uc003ssp.2	+	2	407	c.130G>C	c.(130-132)GAA>CAA	p.E44Q	ARL4A_uc003ssq.2_Missense_Mutation_p.E44Q|ARL4A_uc003ssr.2_Missense_Mutation_p.E44Q|ARL4A_uc003sss.2_Missense_Mutation_p.E44Q	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	44					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		GCAGTTCAATGAATTTGTAAA	0.393													0	0	0	0.008871	0	16	51										C	12728009	G	C	12728009	3	2	97	1	0	0	0	0	1	0	0	0	936	1291	45	1	132	1	ARL4A	7	12728009	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	7373253	12728009	146410654	196	29684										
FERD3L	222894	broad.mit.edu	37	chr7	19184952	19184952	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcgacgaagtccagcaccgTagtgtccacgcagctctccg	11	15	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:19184952T>C	uc003suo.1	-	1	93	c.34A>G	c.(34-36)ACG>GCG	p.T12A	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	12					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						TCCAGCACCGTAGTGTCCACG	0.672													0	0	0	0.00245	0	13	33										C	19184952	T	C	19184952	3	2	97	1	0	0	0	0	1	0	0	0	5816	1638	57	5	470	5	FERD3L	7	19184952	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	6456943	19184952	139953711	197	29685										
GPNMB	10457	broad.mit.edu	37	chr7	23296615	23296615	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gccatcataacgtcttccctGatgggaaaccttttcctcac	6	14	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:23296615G>A	uc003swc.2	+	4	633	c.472G>A	c.(472-474)GAT>AAT	p.D158N	GPNMB_uc003swa.2_Missense_Mutation_p.D158N|GPNMB_uc003swb.2_Missense_Mutation_p.D158N|GPNMB_uc011jyy.1_Intron|GPNMB_uc011jyz.1_Missense_Mutation_p.D59N	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	158	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			CGTCTTCCCTGATGGGAAACC	0.483													0	0	0	0.002836	0	33	123										A	23296615	G	A	23296615	3	1	97	1	0	0	0	0	1	0	0	0	6620	1290	45	1	486	1	GPNMB	7	23296615	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4111663	23296615	135842048	198	29686										
GPNMB	10457	broad.mit.edu	37	chr7	23313138	23313138	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgctcttgcttctgttttaAgacccagcctcgcctttaag	7	12	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:23313138A>G	uc003swc.2	+	10	1627	c.1466_splice	c.e10-2	p.D489_splice	GPNMB_uc003swb.2_Splice_Site_p.D477_splice|GPNMB_uc011jyy.1_Splice_Site_p.D431_splice|GPNMB_uc011jyz.1_Splice_Site_p.D378_splice	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a						negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			TTCTGTTTTAAGACCCAGCCT	0.463											OREG0017893	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.002222	0	41	86										G	23313138	A	G	23313138	5	3	97	1	0	0	0	0	0	0	1	0	6620	86	3	5	1502	5	GPNMB	7	23313138	Splice_Site	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	16523	23313138	135825525	199	29687										
TRA2A	29896	broad.mit.edu	37	chr7	23547040	23547040	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggaaacttgaactcttactGagttggtctgcccatgtaga	10	8	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:23547040G>A	uc003swi.2	-	5	854	c.640C>T	c.(640-642)CAT>TAT	p.H214Y	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_Missense_Mutation_p.H113Y|TRA2A_uc011jzd.1_Missense_Mutation_p.H113Y	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	214	Linker.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						AACTCTTACTGAGTTGGTCTG	0.378													0	0	0	0.00361	0	68	169										A	23547040	G	A	23547040	3	1	97	1	0	0	0	0	1	0	0	0	16430	1304	45	1	224	1	TRA2A	7	23547040	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	233902	23547040	135591623	200	29688										
HOXA11	3207	broad.mit.edu	37	chr7	27222475	27222475	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgttaatttttttttccttCattctcctgttctgaaacca	3	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:27222475C>T	uc003syx.2	-	2	954	c.882G>A	c.(880-882)ATG>ATA	p.M294I	HOXA10_uc003syw.3_5'Flank|HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	294	Homeobox.				branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						TTTTTTCCTTCATTCTCCTGT	0.458			T	NUP98	CML								0	0	0	0.002836	0	32	90										T	27222475	C	T	27222475	3	4	97	1	0	0	0	0	1	0	0	0	7290	826	29	1	63	1	HOXA11	7	27222475	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3675435	27222475	131916188	201	29689										
C7orf41	222166	broad.mit.edu	37	chr7	30197062	30197062	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctctccctgtagttactgggGcttccggatgcagatgacga	12	11	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:30197062G>A	uc011kab.1	+	3	495	c.294G>A	c.(292-294)GGG>GGA	p.G98G	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Silent_p.G98G	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	98											0						AGTTACTGGGGCTTCCGGATG	0.552													0	0	0	0.00361	0	70	216										A	30197062	G	A	30197062	2	1	97	1	0	0	0	0	0	0	0	1	2391	1190	42	2		2	C7orf41	7	30197062	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2974587	30197062	128941601	202	29690										
ELMO1	9844	broad.mit.edu	37	chr7	37272761	37272761	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgccatggtccatcagctcaAcgaaggccgtcagggtgaag	13	11	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:37272761A>T	uc003tfk.1	-	8	795	c.488T>A	c.(487-489)GTT>GAT	p.V163D	ELMO1_uc011kbc.1_Missense_Mutation_p.V67D|ELMO1_uc010kxg.1_Missense_Mutation_p.V163D	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	163					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						CATCAGCTCAACGAAGGCCGT	0.498													0	0	0	0.00333	0	22	46										T	37272761	A	T	37272761	3	4	97	1	0	0	0	0	1	0	0	0	5065	43	2	5	1755	5	ELMO1	7	37272761	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	7075699	37272761	121865902	203	29691										
PSMA2	5683	broad.mit.edu	37	chr7	42964312	42964312	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcatcacagaagctactctCtgtaccagctgagctgtagg	10	11	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:42964312C>T	uc003thy.2	-	4	384	c.336G>A	c.(334-336)CAG>CAA	p.Q112Q	C7orf25_uc010kxr.2_5'UTR|PSMA2_uc010kxt.2_Silent_p.Q34Q|PSMA2_uc003thz.1_Silent_p.Q34Q	NM_002787	NP_002778	P25787	PSA2_HUMAN	proteasome subunit alpha type 2	112					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			large_intestine(2)|ovary(1)	3						AAGCTACTCTCTGTACCAGCT	0.393													0	0	0	0.00623	0	39	95										T	42964312	C	T	42964312	2	4	97	1	0	0	0	0	0	0	0	1	12667	912	32	1		1	PSMA2	7	42964312	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5691551	42964312	116174351	204	29692										
WBSCR22	114049	broad.mit.edu	37	chr7	73112020	73112020	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggagcggcacaggcgccagGgcaggtgagtgccagcctgg	19	11	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:73112020G>A	uc003tyt.2	+	11	845	c.787G>A	c.(787-789)GGC>AGC	p.G263S	WBSCR22_uc003tyu.2_Missense_Mutation_p.G280S|WBSCR22_uc003tyv.2_Missense_Mutation_p.G225S|WBSCR22_uc003tyw.1_Missense_Mutation_p.G126S	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	263						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CAGGCGCCAGGGCAGGTGAGT	0.607													0	0	0	0.003163	0	16	39										A	73112020	G	A	73112020	3	1	97	1	0	0	0	0	1	0	0	0	17262	1232	43	2	829	2	WBSCR22	7	73112020	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	30147708	73112020	86026643	205	29693										
CLDN12	9069	broad.mit.edu	37	chr7	90042400	90042400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggttgccacctggtggctgGgctgctatttttcctggcag	14	10	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:90042400G>A	uc003ukp.2	+	5	1046	c.410G>A	c.(409-411)GGG>GAG	p.G137E	CLDN12_uc003ukq.2_Missense_Mutation_p.G137E|CLDN12_uc010leq.2_Missense_Mutation_p.G137E|CLDN12_uc003ukr.2_Missense_Mutation_p.G137E|CLDN12_uc003uks.2_Missense_Mutation_p.G137E	NM_012129	NP_036261	P56749	CLD12_HUMAN	claudin 12	137	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						CTGGTGGCTGGGCTGCTATTT	0.498													0	0	0	0.004878	0	38	129										A	90042400	G	A	90042400	3	1	97	1	0	0	0	0	1	0	0	0	3474	1232	43	2	412	2	CLDN12	7	90042400	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	16930380	90042400	69096263	206	29694										
FZD1	8321	broad.mit.edu	37	chr7	90895380	90895380	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggggcacgcactgtggcgcaGggcaccaagaaggagggctg	19	10	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:90895380G>A	uc003ula.2	+	1	1598	c.1185G>A	c.(1183-1185)CAG>CAA	p.Q395Q		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	395	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CTGTGGCGCAGGGCACCAAGA	0.612													0	0	0	0.002096	0	33	91										A	90895380	G	A	90895380	2	1	97	1	0	0	0	0	0	0	0	1	6128	991	35	2		2	FZD1	7	90895380	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	852980	90895380	68243283	207	29695										
AKAP9	10142	broad.mit.edu	37	chr7	91694694	91694694	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggtttatagagctggaacaaGaaaaaaatactgaactaatg	9	4	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:91694694G>C	uc003ulg.2	+	25	6352	c.6127G>C	c.(6127-6129)GAA>CAA	p.E2043Q	AKAP9_uc003ulf.2_Missense_Mutation_p.E2043Q|AKAP9_uc003uli.2_Missense_Mutation_p.E1666Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2055	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GCTGGAACAAGAAAAAAATAC	0.323			T	BRAF	papillary thyroid								0	0	0	0.00245	0	14	51										C	91694694	G	C	91694694	3	2	97	1	0	0	0	0	1	0	0	0	459	943	33	1	6225	1	AKAP9	7	91694694	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	799314	91694694	67443969	208	29696										
AKAP9	10142	broad.mit.edu	37	chr7	91695741	91695741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttattgtcattaaactttagGagcaagccattgacagagaa	8	6	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:91695741G>A	uc003ulg.2	+	26	6436	c.6211G>A	c.(6211-6213)GAG>AAG	p.E2071K	AKAP9_uc003ulf.2_Missense_Mutation_p.E2071K|AKAP9_uc003uli.2_Missense_Mutation_p.E1694K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2083	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TAAACTTTAGGAGCAAGCCAT	0.348			T	BRAF	papillary thyroid								0	0	0	0.006122	0	19	61										A	91695741	G	A	91695741	3	1	97	1	0	0	0	0	1	0	0	0	459	1188	41	1	6313	1	AKAP9	7	91695741	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1047	91695741	67442922	209	29697										
ANKIB1	54467	broad.mit.edu	37	chr7	91981884	91981884	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acaagggtcaaatacatctgGatctgatacactcagcttcc	7	11	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:91981884G>T	uc003ulw.2	+	9	1701	c.1325G>T	c.(1324-1326)GGA>GTA	p.G442V		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	442	IBR-type; degenerate.						protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AATACATCTGGATCTGATACA	0.443													1	0	3.1376e-36	0.00361	4.24339e-36	88	229										T	91981884	G	T	91981884	3	4	97	1	0	0	0	0	1	0	0	0	630	1174	41	3	1355	3	ANKIB1	7	91981884	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	286143	91981884	67156779	210	29698										
ANKIB1	54467	broad.mit.edu	37	chr7	92027739	92027739	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cattgagcagctctgagcttTtggaacttggtgacagcctc	11	10	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:92027739T>G	uc003ulw.2	+	20	3122	c.2746T>G	c.(2746-2748)TTG>GTG	p.L916V	ANKIB1_uc010lew.1_Missense_Mutation_p.L185V	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	916							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTCTGAGCTTTTGGAACTTGG	0.507													0	0	0	0.003163	0	16	23										G	92027739	T	G	92027739	3	3	97	1	0	0	0	0	1	0	0	0	630	1838	64	5	2820	5	ANKIB1	7	92027739	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	45855	92027739	67110924	211	29699										
PEX1	5189	broad.mit.edu	37	chr7	92143223	92143223	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	taggggtaacttccactggaGttatcctgactacggcatgc	11	10	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:92143223G>A	uc003uly.2	-	6	1394	c.1298C>T	c.(1297-1299)ACT>ATT	p.T433I	PEX1_uc011khr.1_Missense_Mutation_p.T225I|PEX1_uc010ley.2_Missense_Mutation_p.T433I|PEX1_uc011khs.1_Missense_Mutation_p.T111I|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	433					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTCCACTGGAGTTATCCTGAC	0.299													0	0	0	0.00361	0	52	122										A	92143223	G	A	92143223	3	1	97	1	0	0	0	0	1	0	0	0	11735	1029	36	2	2629	2	PEX1	7	92143223	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	115484	92143223	66995440	212	29700										
MUC17	140453	broad.mit.edu	37	chr7	100678716	100678716	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgaaggaagaactcctttaaCaagtatacctgtcaacacca	6	10	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:100678716C>G	uc003uxp.1	+	3	4072	c.4019C>G	c.(4018-4020)ACA>AGA	p.T1340R	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1340	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTCCTTTAACAAGTATACCT	0.463													0	0	0	0.00361	0	115	307										G	100678716	C	G	100678716	3	3	97	1	0	0	0	0	1	0	0	0	9974	478	17	4	4029	4	MUC17	7	100678716	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	8535493	100678716	58459947	213	29701										
RINT1	60561	broad.mit.edu	37	chr7	105189056	105189056	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaaaatactctcttcctgccTccccttctgtcatcctgccc	3	18	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:105189056T>A	uc003vda.1	+	7	1126	c.895T>A	c.(895-897)TCC>ACC	p.S299T	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	299	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TCTTCCTGCCTCCCCTTCTGT	0.433													0	0	0	0.00361	0	68	154										A	105189056	T	A	105189056	3	1	97	1	0	0	0	0	1	0	0	0	13376	1551	54	5	921	5	RINT1	7	105189056	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	4510340	105189056	53949607	214	29702										
PIK3CG	5294	broad.mit.edu	37	chr7	106508023	106508023	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggcatggagctggagaactAtaaacagcccgtggtgctga	15	8	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:106508023A>G	uc003vdv.3	+	2	102	c.17A>G	c.(16-18)TAT>TGT	p.Y6C	PIK3CG_uc003vdu.2_Missense_Mutation_p.Y6C|PIK3CG_uc003vdw.2_Missense_Mutation_p.Y6C	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	6					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CTGGAGAACTATAAACAGCCC	0.582													0	0	0	0.004656	0	24	72										G	106508023	A	G	106508023	3	3	97	1	0	0	0	0	1	0	0	0	11916	449	16	5	19	5	PIK3CG	7	106508023	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1318967	106508023	52630640	215	29703										
LRRN3	54674	broad.mit.edu	37	chr7	110763553	110763553	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggaaaacttagaaagcatctCtttttacgataacaggctta	7	7	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:110763553C>G	uc003vft.3	+	4	1771	c.725C>G	c.(724-726)TCT>TGT	p.S242C	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.S242C|LRRN3_uc003vfs.3_Missense_Mutation_p.S242C	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	242	Extracellular (Potential).|LRR 8.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GAAAGCATCTCTTTTTACGAT	0.343													0	0	0	0.007291	0	26	61										G	110763553	C	G	110763553	3	3	97	1	0	0	0	0	1	0	0	0	9036	913	32	1	727	1	LRRN3	7	110763553	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4255530	110763553	48375110	216	29704										
ING3	54556	broad.mit.edu	37	chr7	120610799	120610799	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcctcctcctcttcttccttAtcatcgtgttcttcatcatc	2	16	6	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:120610799A>T	uc003vjn.2	+	10	1100	c.966A>T	c.(964-966)TTA>TTT	p.L322F	ING3_uc003vjo.2_Missense_Mutation_p.L96F|ING3_uc003vjp.2_Missense_Mutation_p.L322F|ING3_uc011kns.1_Missense_Mutation_p.L307F	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	322	Poly-Ser.				histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					CTTCTTCCTTATCATCGTGTT	0.378													0	0	0	0.007413	0	17	45										T	120610799	A	T	120610799	3	4	97	1	0	0	0	0	1	0	0	0	7737	446	16	5	1020	5	ING3	7	120610799	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	9847246	120610799	38527864	217	29705										
SVOPL	136306	broad.mit.edu	37	chr7	138312175	138312175	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggctcagccgtcttcccagGaaattgatgcccagtatatt	9	11	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:138312175G>A	uc011kqh.1	-	11	1101	c.1101C>T	c.(1099-1101)TTC>TTT	p.F367F	SVOPL_uc003vue.2_Silent_p.F215F	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	367	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0						GTCTTCCCAGGAAATTGATGC	0.403													0	0	0	0.001984	0	6	23										A	138312175	G	A	138312175	2	1	97	1	0	0	0	0	0	0	0	1	15421	1165	41	1		1	SVOPL	7	138312175	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	17701376	138312175	20826488	218	29706										
WEE2	494551	broad.mit.edu	37	chr7	141427156	141427156	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttctgcagcagctctggccaGaaatacagttctccggcctt	9	13	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:141427156G>A	uc003vwn.2	+	10	1851	c.1445G>A	c.(1444-1446)AGA>AAA	p.R482K	FLJ40852_uc011krh.1_RNA|FLJ40852_uc010lnm.2_RNA|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	482	Protein kinase.				egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					GCTCTGGCCAGAAATACAGTT	0.458													0	0	0	0.00361	0	57	174										A	141427156	G	A	141427156	3	1	97	1	0	0	0	0	1	0	0	0	17342	942	33	1	1483	1	WEE2	7	141427156	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3114981	141427156	17711507	219	29707										
OR2A12	346525	broad.mit.edu	37	chr7	143793100	143793100	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcagaggtgaaaggggctctAaagagagtcctttggaaaca	14	6	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:143793100A>G	uc011kty.1	+	1	900	c.900A>G	c.(898-900)CTA>CTG	p.L300L		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AAGGGGCTCTAAAGAGAGTCC	0.453													0	0	0	0.00361	0	83	268										G	143793100	A	G	143793100	2	3	97	1	0	0	0	0	0	0	0	1	10975	349	13	5		5	OR2A12	7	143793100	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2365944	143793100	15345563	220	29708										
MLL3	58508	broad.mit.edu	37	chr7	151864230	151864230	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttttgcaaacctatttattaCctgttctagctgtttctgaa	5	8	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:151864230C>T	uc003wla.2	-	42	9969	c.9750_splice	c.e42+1	p.Q3250_splice	MLL3_uc003wkz.2_Splice_Site_p.Q2311_splice|MLL3_uc003wky.2_Splice_Site_p.Q759_splice	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTATTTATTACCTGTTCTAGC	0.368			N		medulloblastoma								0	0	0	0.00499	0	18	57										T	151864230	C	T	151864230	5	4	97	1	0	0	0	0	0	0	1	0	9622	521	18	2	5056	2	MLL3	7	151864230	Splice_Site	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	8071130	151864230	7274433	221	29709										
PAXIP1	22976	broad.mit.edu	37	chr7	154739621	154739621	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cttaaagtgtaccttaaagaGtggagaaacgtgtgcccgtt	11	7	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:154739621G>T	uc003wlp.2	-	17	2957	c.2914C>A	c.(2914-2916)CTC>ATC	p.L972I	LOC100132707_uc003wlo.2_RNA|PAXIP1_uc003wlq.1_Missense_Mutation_p.L938I|PAXIP1_uc011kvs.1_Missense_Mutation_p.L936I	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	972	Interaction with TP53BP1.|BRCT 6.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		ACCTTAAAGAGTGGAGAAACG	0.448													1	0	5.10508e-28	0.00361	6.88038e-28	61	194										T	154739621	G	T	154739621	3	4	97	1	0	0	0	0	1	0	0	0	11487	1029	36	4	315	4	PAXIP1	7	154739621	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2875391	154739621	4399042	222	29710										
NOM1	64434	broad.mit.edu	37	chr7	156745289	156745289	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acatgtaaaaggtctacttaAcaggtgaccttgtagtgttg	10	6	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr7:156745289A>G	uc003wmy.2	+	2	1124	c.1109A>G	c.(1108-1110)AAC>AGC	p.N370S		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	370	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GGTCTACTTAACAGGTGACCT	0.413													0	0	0	0.000978	0	12	34										G	156745289	A	G	156745289	3	3	97	1	0	0	0	0	1	0	0	0	10530	43	2	5	1115	5	NOM1	7	156745289	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2005668	156745289	2393374	223	29711										
DLC1	10395	broad.mit.edu	37	chr8	13357474	13357474	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgcctgcaagctgtcagctActagtccatgatgacatgct	9	11	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:13357474A>G	uc003wwm.2	-	2	551	c.107T>C	c.(106-108)GTA>GCA	p.V36A	DLC1_uc003wwn.2_Missense_Mutation_p.V36A|DLC1_uc011kxy.1_Missense_Mutation_p.V36A	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	36					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GCTGTCAGCTACTAGTCCATG	0.453													0	0	0	0.00361	0	97	164										G	13357474	A	G	13357474	3	3	97	1	0	0	0	0	1	0	0	0	4550	391	14	5	4632	5	DLC1	8	13357474	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08		13357474	133006548	224	29712										
PSD3	23362	broad.mit.edu	37	chr8	18662314	18662314	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttccacattgctgctggtacCattactgagattttctgggg	10	9	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:18662314C>A	uc003wza.2	-	5	1832	c.1729G>T	c.(1729-1731)GGT>TGT	p.G577C	PSD3_uc003wyy.2_Missense_Mutation_p.G43C|PSD3_uc003wyz.2_5'UTR	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	577	SEC7.				regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CTGCTGGTACCATTACTGAGA	0.448													1	0	1.77355e-41	0.00361	2.40697e-41	75	284										A	18662314	C	A	18662314	3	1	97	1	0	0	0	0	1	0	0	0	12648	594	21	4	1462	4	PSD3	8	18662314	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5304840	18662314	127701708	225	29713										
SH2D4A	63898	broad.mit.edu	37	chr8	19190582	19190582	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctgtaatgaaattattgctGagagggcccggctgaaagca	12	7	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:19190582G>A	uc003wzb.2	+	3	634	c.298G>A	c.(298-300)GAG>AAG	p.E100K	SH2D4A_uc011kym.1_Missense_Mutation_p.E55K|SH2D4A_uc003wzc.2_Missense_Mutation_p.E100K	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	100						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		AATTATTGCTGAGAGGGCCCG	0.458													0	0	0	0.001786	0	31	103										A	19190582	G	A	19190582	3	1	97	1	0	0	0	0	1	0	0	0	14235	1291	45	1	354	1	SH2D4A	8	19190582	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	528268	19190582	127173440	226	29714										
PDLIM2	64236	broad.mit.edu	37	chr8	22442884	22442884	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccccgctgctgaccgcctgtCctactcaggccgccctggaa	10	19	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:22442884C>G	uc003xby.2	+	6	912	c.512C>G	c.(511-513)TCC>TGC	p.S171C	PDLIM2_uc003xbx.1_Missense_Mutation_p.S171C|PDLIM2_uc003xbz.2_Missense_Mutation_p.S171C|PDLIM2_uc003xca.2_Missense_Mutation_p.S171C|PDLIM2_uc003xcb.2_Missense_Mutation_p.S171C|PDLIM2_uc003xcc.1_Missense_Mutation_p.S171C	NM_021630	NP_067643	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 isoform 2	171						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		GACCGCCTGTCCTACTCAGGC	0.672													0	0	0	0.001168	0	5	30										G	22442884	C	G	22442884	3	3	97	1	0	0	0	0	1	0	0	0	11680	855	30	1	530	1	PDLIM2	8	22442884	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3252302	22442884	123921138	227	29715										
TNFRSF10A	8797	broad.mit.edu	37	chr8	23056919	23056919	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcgttgtgagcattgtcctCagccccaggccctcgtagga	11	14	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:23056919C>T	uc003xda.2	-	8	939	c.874G>A	c.(874-876)GAG>AAG	p.E292K		NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	292	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		GCATTGTCCTCAGCCCCAGGC	0.587													0	0	0	0.007835	0	39	58										T	23056919	C	T	23056919	3	4	97	1	0	0	0	0	1	0	0	0	16277	835	29	1	544	1	TNFRSF10A	8	23056919	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	614035	23056919	123307103	228	29716										
CHMP7	91782	broad.mit.edu	37	chr8	23112797	23112797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtatcgtctgtatcagaactCgcccctctcctcccaccccg	6	19	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:23112797C>T	uc003xdc.2	+	4	1157	c.509C>T	c.(508-510)TCG>TTG	p.S170L	CHMP7_uc011kzs.1_RNA|CHMP7_uc003xdd.2_Missense_Mutation_p.S60L|CHMP7_uc003xde.2_Missense_Mutation_p.S28L	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	170					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TATCAGAACTCGCCCCTCTCC	0.592													0	0	0	0.004007	0	16	53										T	23112797	C	T	23112797	3	4	97	1	0	0	0	0	1	0	0	0	3361	893	31	1	519	1	CHMP7	8	23112797	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	55878	23112797	123251225	229	29717										
NEFM	4741	broad.mit.edu	37	chr8	24775841	24775841	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaaaaggcagtgggagggaaGaggagaaaggcgttgtcacc	17	5	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:24775841G>A	uc003xed.3	+	3	2506	c.2473G>A	c.(2473-2475)GAG>AAG	p.E825K	NEFM_uc011lac.1_Missense_Mutation_p.E607K|NEFM_uc010lue.2_Missense_Mutation_p.E449K	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	825	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		tgggagggaagaggagaaagG	0.229													0	0	0	0.002299	0	22	21										A	24775841	G	A	24775841	3	1	97	1	0	0	0	0	1	0	0	0	10316	943	33	1	2483	1	NEFM	8	24775841	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1663044	24775841	121588181	230	29718										
EPHX2	2053	broad.mit.edu	37	chr8	27361273	27361273	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caggcagctctcatgctcagGaagaaaggtaaggatctgat	12	8	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:27361273G>T	uc003xfu.2	+	3	420	c.339G>T	c.(337-339)AGG>AGT	p.R113S	EPHX2_uc010lut.1_Missense_Mutation_p.R113S|EPHX2_uc010luu.2_Missense_Mutation_p.R113S|EPHX2_uc010luv.2_Missense_Mutation_p.R47S|EPHX2_uc003xfv.2_Missense_Mutation_p.R60S|EPHX2_uc010luw.2_Missense_Mutation_p.R47S|EPHX2_uc011lam.1_5'Flank	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	113	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	TCATGCTCAGGAAGAAAGGTA	0.493													1	0	2.64397e-27	0.005443	3.55726e-27	23	97										T	27361273	G	T	27361273	3	4	97	1	0	0	0	0	1	0	0	0	5180	1165	41	3	349	3	EPHX2	8	27361273	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2585432	27361273	119002749	231	29719										
C8orf41	80185	broad.mit.edu	37	chr8	33370001	33370001	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgcatcttttacattgcctCgtcgtgcctccgggcgggca	11	14	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:33370001C>T	uc003xjl.3	-	1	656	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	C8orf41_uc003xjk.3_Missense_Mutation_p.R44Q|C8orf41_uc010lvv.2_Missense_Mutation_p.R44Q|C8orf41_uc003xjm.3_Missense_Mutation_p.R44Q|C8orf41_uc003xjn.1_Missense_Mutation_p.R44Q	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	44							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		TACATTGCCTCGTCGTGCCTC	0.507													0	0	0	0.004289	0	32	151										T	33370001	C	T	33370001	3	4	97	1	0	0	0	0	1	0	0	0	2427	884	31	1	1423	1	C8orf41	8	33370001	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	6008728	33370001	112994021	232	29720										
ADAM2	2515	broad.mit.edu	37	chr8	39645638	39645638	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cacatcatgaggacgtaaaaCaagataagatgttttccatc	7	8	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:39645638C>A	uc003xnj.2	-	9	850	c.775G>T	c.(775-777)GTT>TTT	p.V259F	ADAM2_uc003xnk.2_Missense_Mutation_p.V240F|ADAM2_uc011lck.1_Missense_Mutation_p.V259F|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	259	Extracellular (Potential).|Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		GGACGTAAAACAAGATAAGAT	0.308													1	0	1.96292e-10	0.001523	2.48637e-10	22	95										A	39645638	C	A	39645638	3	1	97	1	0	0	0	0	1	0	0	0	241	478	17	4	1480	4	ADAM2	8	39645638	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	6275637	39645638	106718384	233	29721										
RB1CC1	9821	broad.mit.edu	37	chr8	53568671	53568671	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tagggcagtctgaatagcttCatctttttcacaattaagct	7	8	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:53568671C>T	uc003xre.3	-	15	4276	c.3718G>A	c.(3718-3720)GAA>AAA	p.E1240K	RB1CC1_uc003xrf.3_Missense_Mutation_p.E1240K	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	1240	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TGAATAGCTTCATCTTTTTCA	0.343													0	0	0	0.00361	0	80	104										T	53568671	C	T	53568671	3	4	97	1	0	0	0	0	1	0	0	0	13099	835	29	1	1106	1	RB1CC1	8	53568671	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	13923033	53568671	92795351	234	29722										
PENK	5179	broad.mit.edu	37	chr8	57353869	57353869	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccgtatcttttttccatttCaggaacttctttggagtaac	6	9	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:57353869C>T	uc003xsz.2	-	2	847	c.766G>A	c.(766-768)GAA>AAA	p.E256K	PENK_uc003xta.3_Missense_Mutation_p.E256K	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	256					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTTTCCATTTCAGGAACTTCT	0.502													0	0	0	0.00361	0	105	175										T	57353869	C	T	57353869	3	4	97	1	0	0	0	0	1	0	0	0	11727	835	29	1	41	1	PENK	8	57353869	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3785198	57353869	89010153	235	29723										
TOX	9760	broad.mit.edu	37	chr8	59728257	59728257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agctgaggaggttgagatgtCttcacgtcaacaggttcact	12	8	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:59728257C>G	uc003xtw.1	-	7	1253	c.1032G>C	c.(1030-1032)AAG>AAC	p.K344N		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	344						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GTTGAGATGTCTTCACGTCAA	0.507													0	0	0	0.00632	0	27	74										G	59728257	C	G	59728257	3	3	97	1	0	0	0	0	1	0	0	0	16374	912	32	1	560	1	TOX	8	59728257	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2374388	59728257	86635765	236	29724										
ZFHX4	79776	broad.mit.edu	37	chr8	77618118	77618118	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctttaccccgagtactcctGgcacaccagggcctggagga	12	14	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:77618118G>T	uc003yav.2	+	2	2182	c.1795G>T	c.(1795-1797)GGC>TGC	p.G599C	ZFHX4_uc003yat.1_Missense_Mutation_p.G599C|ZFHX4_uc003yau.1_Missense_Mutation_p.G599C|ZFHX4_uc003yaw.1_Missense_Mutation_p.G599C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	599						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAGTACTCCTGGCACACCAGG	0.572										HNSCC(33;0.089)			1	0	1.4374e-25	0.00361	1.92064e-25	49	66										T	77618118	G	T	77618118	3	4	97	1	0	0	0	0	1	0	0	0	17632	1348	47	4	1797	4	ZFHX4	8	77618118	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	17889861	77618118	68745904	237	29725										
CHMP4C	92421	broad.mit.edu	37	chr8	82670747	82670747	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggcagaagaagaggatgatGatatcaaacaattggcagct	13	5	1	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:82670747G>A	uc003ycl.2	+	5	844	c.670G>A	c.(670-672)GAT>AAT	p.D224N		NM_152284	NP_689497	Q96CF2	CHM4C_HUMAN	chromatin modifying protein 4C	224	Intramolecular interaction with N- terminus (By similarity).				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(2)	2						AGAGGATGATGATATCAAACA	0.318													0	0	0	0.001882	0	20	98										A	82670747	G	A	82670747	3	1	97	1	0	0	0	0	1	0	0	0	3358	1290	45	1	688	1	CHMP4C	8	82670747	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5052629	82670747	63693275	238	29726										
NBN	4683	broad.mit.edu	37	chr8	90995014	90995014	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggctgatcgactgatcatttTcaatcagaatggcacagttt	9	8	3	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:90995014T>G	uc003yej.1	-	2	217	c.107A>C	c.(106-108)GAA>GCA	p.E36A	NBN_uc003yei.1_5'UTR|NBN_uc011lgb.1_Missense_Mutation_p.E36A	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	36	FHA.				cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			CTGATCATTTTCAATCAGAAT	0.343								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.003755	0	35	116										G	90995014	T	G	90995014	3	3	97	1	0	0	0	0	1	0	0	0	10191	1783	62	5	2217	5	NBN	8	90995014	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	8324267	90995014	55369008	239	29727										
RGS22	26166	broad.mit.edu	37	chr8	101076156	101076156	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaaggagtgtcttgtagagaTacagacacctcttcttcttc	9	9	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:101076156T>C	uc003yjb.1	-	8	1035	c.840A>G	c.(838-840)GTA>GTG	p.V280V	RGS22_uc003yja.1_Silent_p.V99V|RGS22_uc003yjc.1_Silent_p.V268V|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	280					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CTTGTAGAGATACAGACACCt	0.338													0	0	0	0.001855	0	14	248										C	101076156	T	C	101076156	2	2	97	1	0	0	0	0	0	0	0	1	13305	1393	49	5		5	RGS22	8	101076156	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	10081142	101076156	45287866	240	29728										
PKHD1L1	93035	broad.mit.edu	37	chr8	110460573	110460573	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggctcagccatgtccacagTtgtatttgagtacccgctta	9	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:110460573T>C	uc003yne.2	+	39	6082	c.5978T>C	c.(5977-5979)GTT>GCT	p.V1993A		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1993	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATGTCCACAGTTGTATTTGAG	0.408										HNSCC(38;0.096)			0	0	0	0.001984	0	7	46										C	110460573	T	C	110460573	3	2	97	1	0	0	0	0	1	0	0	0	11972	1725	60	5	6132	5	PKHD1L1	8	110460573	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	9384417	110460573	35903449	241	29729										
NDUFB9	4715	broad.mit.edu	37	chr8	125555358	125555358	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgatactttgcttgtttgatGagagcccggtttgaagaaca	11	7	0	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:125555358G>A	uc003yrg.3	+	2	217	c.132G>A	c.(130-132)ATG>ATA	p.M44I	NDUFB9_uc011lim.1_Missense_Mutation_p.M44I	NM_005005	NP_004996	Q9Y6M9	NDUB9_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	44					mitochondrial electron transport, NADH to ubiquinone|sensory perception of sound|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)|skin(1)	2	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)		NADH(DB00157)	CTTGTTTGATGAGAGCCCGGT	0.448													0	0	0	0.003163	0	14	80										A	125555358	G	A	125555358	3	1	97	1	0	0	0	0	1	0	0	0	10288	1290	45	1	138	1	NDUFB9	8	125555358	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	15094785	125555358	20808664	242	29730										
DENND3	22898	broad.mit.edu	37	chr8	142148141	142148141	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggggtgtgtgcgtggccactGaacctaaggaggattgcgtc	17	8	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:142148141G>A	uc003yvy.2	+	3	444	c.166G>A	c.(166-168)GAA>AAA	p.E56K	DENND3_uc003yvw.1_Missense_Mutation_p.E69K|DENND3_uc003yvx.2_Missense_Mutation_p.E136K|DENND3_uc010mep.2_Missense_Mutation_p.E69K	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	56	UDENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CGTGGCCACTGAACCTAAGGA	0.572													0	0	0	0.001168	0	5	19										A	142148141	G	A	142148141	3	1	97	1	0	0	0	0	1	0	0	0	4432	1291	45	1	172	1	DENND3	8	142148141	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	16592783	142148141	4215881	243	29731										
RHPN1	114822	broad.mit.edu	37	chr8	144462009	144462009	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccaccggcaggtggcagccgAgtacaggctagtgcaccgga	15	13	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:144462009A>G	uc003yyb.2	+	9	1089	c.956A>G	c.(955-957)GAG>GGG	p.E319G		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	319	BRO1.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GTGGCAGCCGAGTACAGGCTA	0.667													0	0	0	0.004482	0	8	27										G	144462009	A	G	144462009	3	3	97	1	0	0	0	0	1	0	0	0	13350	304	11	5	990	5	RHPN1	8	144462009	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2313868	144462009	1902013	244	29732										
EEF1D	1936	broad.mit.edu	37	chr8	144668447	144668447	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caatgtcacggaggatcacgCtggcgccgttctcctgcaga	12	13	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:144668447C>T	uc011lki.1	-	3	400	c.131G>A	c.(130-132)AGC>AAC	p.S44N	EEF1D_uc003yyp.1_Intron|EEF1D_uc003yyq.1_Missense_Mutation_p.S460N|EEF1D_uc011lkj.1_Missense_Mutation_p.S409N|EEF1D_uc003yyr.2_Missense_Mutation_p.S410N|EEF1D_uc003yyt.2_Missense_Mutation_p.S410N|EEF1D_uc011lkk.1_Missense_Mutation_p.S44N|EEF1D_uc003yys.2_Missense_Mutation_p.S44N|EEF1D_uc003yyv.2_Intron|EEF1D_uc003yyu.2_Missense_Mutation_p.S44N|EEF1D_uc011lkl.1_Missense_Mutation_p.S44N	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	44				S -> T (in Ref. 1; CAA79716).	positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GAGGATCACGCTGGCGCCGTT	0.493													0	0	0	0.00245	0	13	18										T	144668447	C	T	144668447	3	4	97	1	0	0	0	0	1	0	0	0	4926	797	28	2	738	2	EEF1D	8	144668447	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	206438	144668447	1695575	245	29733										
TIGD5	84948	broad.mit.edu	37	chr8	144680461	144680461	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agatcgaccgcgccgtgtacGcctggttcctggcgctgcgc	14	15	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:144680461G>A	uc003yyx.1	+	1	241	c.241G>A	c.(241-243)GCC>ACC	p.A81T	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	130					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CGCCGTGTACGCCTGGTTCCT	0.701													0	0	0	0.00499	0	14	19										A	144680461	G	A	144680461	3	1	97	1	0	0	0	0	1	0	0	0	15896	1087	38	2	390	2	TIGD5	8	144680461	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	12014	144680461	1683561	246	29734										
NFKBIL2	4796	broad.mit.edu	37	chr8	145660258	145660258	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggggcaggtcccacgaagtCacctcagccaacacctggaa	12	14	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:145660258C>T	uc011llg.1	-	20	3036	c.3021G>A	c.(3019-3021)GTG>GTA	p.V1007V	uc011llh.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1007					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCCACGAAGTCACCTCAGCCA	0.667													0	0	0	0.001368	0	12	60										T	145660258	C	T	145660258	2	4	97	1	0	0	0	0	0	0	0	1	10382	813	29	1		1	NFKBIL2	8	145660258	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	979797	145660258	703764	247	29735										
KIFC2	90990	broad.mit.edu	37	chr8	145697774	145697774	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctccagggcctcccgagcgCctggccgtgaggcagggccc	16	17	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:145697774C>T	uc003zcz.2	+	15	1703	c.1638C>T	c.(1636-1638)CGC>CGT	p.R546R	KIFC2_uc003zda.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	546	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTCCCGAGCGCCTGGCCGTGA	0.662													0	0	0	0.00499	0	18	42										T	145697774	C	T	145697774	2	4	97	1	0	0	0	0	0	0	0	1	8313	726	26	2		2	KIFC2	8	145697774	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	37516	145697774	666248	248	29736										
RECQL4	9401	broad.mit.edu	37	chr8	145738372	145738372	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggtacttgggcacaggcctCtccccacccacggccccttc	10	19	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr8:145738372C>T	uc003zdj.2	-	16	2645	c.2613G>A	c.(2611-2613)GAG>GAA	p.E871E		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	871					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCACAGGCCTCTCCCCACCCA	0.667			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				0	0	0	0.000602	0	5	7										T	145738372	C	T	145738372	2	4	97	1	0	0	0	0	0	0	0	1	13202	912	32	1		1	RECQL4	8	145738372	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	40598	145738372	625650	249	29737										
KIAA2026	158358	broad.mit.edu	37	chr9	6007547	6007547	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcccaggatgcggtagccctGctgtagctcgtaggtcagct	14	12	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:6007547G>A	uc003zjq.3	-	1	457	c.241C>T	c.(241-243)CAG>TAG	p.Q81*		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	81										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CGGTAGCCCTGCTGTAGCTCG	0.662													0	0	0	0.002222	0	41	28										A	6007547	G	A	6007547	4	1	97	1	0	0	0	0	0	1	0	0	8270	1328	46	2	6102	2	KIAA2026	9	6007547	Nonsense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		6007547	135205884	250	29738										
CDKN2A	1029	broad.mit.edu	37	chr9	21971209	21971209	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgctgcccatcatcatgaccTgccagagagaacagaatggt	10	12	2	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:21971209T>A	uc003zpk.2	-	2	363	c.151_splice	c.e2-1	p.V51_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site_p.G106_splice	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(19)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CATCATGACCTGCCAGAGAGA	0.667		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.00245	0	12	12										A	21971209	T	A	21971209	5	1	97	1	0	0	0	0	0	0	1	0	3161	1594	55	5	329	5	CDKN2A	9	21971209	Splice_Site	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	15963662	21971209	119242222	251	29739										
DCAF12	25853	broad.mit.edu	37	chr9	34125208	34125208	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgacttcccggttcttcaagTagtatactaaggatctcttc	7	10	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:34125208T>A	uc003ztt.2	-	2	488	c.146A>T	c.(145-147)TAC>TTC	p.Y49F		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	49						centrosome|CUL4 RING ubiquitin ligase complex					0						GTTCTTCAAGTAGTATACTAA	0.463													0	0	0	0.00361	0	49	47										A	34125208	T	A	34125208	3	1	97	1	0	0	0	0	1	0	0	0	4263	1638	57	5	1247	5	DCAF12	9	34125208	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	12153999	34125208	107088223	252	29740										
GNE	10020	broad.mit.edu	37	chr9	36276896	36276896	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttccgaattacttacatgagGtccttgaaagcatgactccc	7	11	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:36276896G>A	uc010mli.2	-	1	146	c.46C>T	c.(46-48)CCT>TCT	p.P16S	CLTA_uc003zzf.1_Intron|GNE_uc010mlj.2_Silent_p.D48D	NM_001128227	NP_001121699	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	Error:Variant_position_missing_in_Q9Y223_after_alignment					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CTTACATGAGGTCCTTGAAAG	0.408													0	0	0	0.00361	0	78	78										A	36276896	G	A	36276896	3	1	97	1	0	0	0	0	1	0	0	0	6522	1261	44	2	2263	2	GNE	9	36276896	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2151688	36276896	104936535	253	29741										
SHB	6461	broad.mit.edu	37	chr9	38016031	38016031	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcatgatcctctgtgcctcaTagggctccatgtagccagca	9	13	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:38016031T>C	uc004aax.2	-	2	1383	c.815A>G	c.(814-816)TAT>TGT	p.Y272C		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	272	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		CTGTGCCTCATAGGGCTCCAT	0.557													0	0	0	0.00361	0	164	143										C	38016031	T	C	38016031	3	2	97	1	0	0	0	0	1	0	0	0	14268	1406	49	5	734	5	SHB	9	38016031	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1739135	38016031	103197400	254	29742										
C9orf3	84909	broad.mit.edu	37	chr9	97522147	97522147	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tacttgtgaagcactatgtaCtggatttggatgtggatttt	11	4	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:97522147C>A	uc004ava.2	+	1	217	c.82C>A	c.(82-84)CTG>ATG	p.L28M	C9orf3_uc011lui.1_RNA|C9orf3_uc004aux.1_Missense_Mutation_p.L28M|C9orf3_uc004auy.2_Missense_Mutation_p.L28M|C9orf3_uc004auz.1_Missense_Mutation_p.L28M	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	28					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GCACTATGTACTGGATTTGGA	0.443													1	0	6.32553e-13	0.004656	8.10459e-13	28	62										A	97522147	C	A	97522147	3	1	97	1	0	0	0	0	1	0	0	0	2477	564	20	4	84	4	C9orf3	9	97522147	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	59506116	97522147	43691284	255	29743										
EPB41L4B	54566	broad.mit.edu	37	chr9	112018495	112018495	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccaagagaatattcacagcCatctcttccctacaaacaaa	3	13	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:112018495C>T	uc004bdz.1	-	9	1145	c.850G>A	c.(850-852)GGC>AGC	p.G284S	EPB41L4B_uc004bea.2_Missense_Mutation_p.G284S	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	284	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TATTCACAGCCATCTCTTCCC	0.393													0	0	0	0.00361	0	79	51										T	112018495	C	T	112018495	3	4	97	1	0	0	0	0	1	0	0	0	5156	594	21	2	2076	2	EPB41L4B	9	112018495	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	14496348	112018495	29194936	256	29744										
TLR4	7099	broad.mit.edu	37	chr9	120470999	120471017	+	Splice_Site	DEL	TTTATCCAGGTAATGAATC	TTTATCCAGGTAATGAATC	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccagaactgcaggtgctggaTttatccaggtaatgaatcca					rs148067660	by1000genomes	TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:120470999_120471017delTTTATCCAGGTAATGAATC	uc004bjz.2	+	2	551	c.260_splice	c.e2+1	p.R87_splice	TLR4_uc004bka.2_Splice_Site_p.R47_splice|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor						activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AGGTGCTGGATTTATCCAGGTAATGAATCCACTTTTACA	0.438																		43	132	---	---								-	120471017	TTTATCCAGGTAATGAATC	-	120470999	8	5	97	1	0	1	0	1	0	0	1	0	15950	1490	52	0	258	0	TLR4	9	120470999	Splice_Site	DEL	TTTATCCAGGTAATGAATC	TCGA-G2-A2ES-01A-11D-A17V-08	8452504	120470999	20742432	257	29745										
CEP110	11064	broad.mit.edu	37	chr9	123852674	123852674	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctttctaaagacggtggcaaGaaatttaaggtaggttacca	10	6	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:123852674G>A	uc004bkx.1	+	2	370	c.339G>A	c.(337-339)AAG>AAA	p.K113K	CEP110_uc004bkw.2_Silent_p.K113K	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	113					cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ACGGTGGCAAGAAATTTAAGG	0.313													0	0	0	0.00361	0	53	45										A	123852674	G	A	123852674	2	1	97	1	0	0	0	0	0	0	0	1	3245	933	33	1		1	CEP110	9	123852674	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3381675	123852674	17360757	258	29746										
C9orf96	169436	broad.mit.edu	37	chr9	136269137	136269137	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agccctgctggtgaacaatgCctaccggggactggccagcc	13	14	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr9:136269137C>T	uc004cdk.2	+	16	1758	c.1697C>T	c.(1696-1698)GCC>GTC	p.A566V	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	566							ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GTGAACAATGCCTACCGGGGA	0.612											OREG0019586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	46	38										T	136269137	C	T	136269137	3	4	97	1	0	0	0	0	1	0	0	0	2508	739	26	2	1759	2	C9orf96	9	136269137	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	12416463	136269137	4944294	259	29747										
VIM	7431	broad.mit.edu	37	chr10	17275816	17275816	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caggaacagcatgtccaaatCgatgtggatgtttccaagcc	10	10	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:17275816C>T	uc001iou.2	+	5	1181	c.768C>T	c.(766-768)ATC>ATT	p.I256I	VIM_uc001iov.1_Silent_p.I256I|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.I256I|VIM_uc001ioy.1_Silent_p.I256I|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.I256I|VIM_uc001ipc.1_Silent_p.I256I	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	256	Rod.|Linker 12.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						ATGTCCAAATCGATGTGGATG	0.537													0	0	0	0.00361	0	64	91										T	17275816	C	T	17275816	2	4	97	1	0	0	0	0	0	0	0	1	17163	874	31	1		1	VIM	10	17275816	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08		17275816	118258931	260	29748										
SLC39A12	221074	broad.mit.edu	37	chr10	18242459	18242459	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaacggaatgcaaggagattGcaatctggttagtgaaatag	12	4	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:18242459G>A	uc001ipo.2	+	2	527	c.254G>A	c.(253-255)TGC>TAC	p.C85Y	SLC39A12_uc001ipn.2_Missense_Mutation_p.C85Y|SLC39A12_uc001ipp.2_Missense_Mutation_p.C85Y|SLC39A12_uc010qck.1_Intron	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	85	Extracellular (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						CAAGGAGATTGCAATCTGGTT	0.453													0	0	0	0.00632	0	29	63										A	18242459	G	A	18242459	3	1	97	1	0	0	0	0	1	0	0	0	14615	1319	46	2	256	2	SLC39A12	10	18242459	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	966643	18242459	117292288	261	29749										
YME1L1	10730	broad.mit.edu	37	chr10	27415685	27415685	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atttttcaagaattcaacaaCttcctgtaattcttgtttag	4	7	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:27415685C>A	uc001iti.2	-	10	1242	c.1060G>T	c.(1060-1062)GTT>TTT	p.V354F	YME1L1_uc001itj.2_Missense_Mutation_p.V297F|YME1L1_uc010qdl.1_Missense_Mutation_p.V264F|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	354					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						AATTCAACAACTTCCTGTAAT	0.318													1	0	8.12818e-05	0.001984	9.90901e-05	7	45										A	27415685	C	A	27415685	3	1	97	1	0	0	0	0	1	0	0	0	17484	565	20	4	1305	4	YME1L1	10	27415685	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	9173226	27415685	108119062	262	29750										
ALOX5	240	broad.mit.edu	37	chr10	45920479	45920480	+	Frame_Shift_Ins	INS	-	-	G													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaatggctgcaaccctgtgtINStgatccggcgctgcacagag							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:45920479_45920480insG	uc001jce.2	+	6	832_833	c.733_734insG	c.(733-735)TTGfs	p.L245fs	ALOX5_uc009xmt.2_Frame_Shift_Ins_p.L245fs|ALOX5_uc010qfg.1_Frame_Shift_Ins_p.L245fs	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	245	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	CAACCCTGTGTTGATCCGGCGC	0.604																		55	142	---	---								G	45920480	-	G	45920479	7	5	97	1	0	1	1	0	0	0	0	0	540	1722	60	0	755	0	ALOX5	10	45920479	Frame_Shift_Ins	INS	-	TCGA-G2-A2ES-01A-11D-A17V-08	18504794	45920479	89614268	263	29751										
GPRIN2	9721	broad.mit.edu	37	chr10	46999257	46999257	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagccattcagacctggtccGtagcacccagatgcggggac	13	13	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:46999257G>A	uc001jec.2	+	3	512	c.377G>A	c.(376-378)CGT>CAT	p.R126H	GPRIN2_uc010qfq.1_5'Flank	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	126											0						GACCTGGTCCGTAGCACCCAG	0.642													0	0	0	0.00308	0	8	55										A	46999257	G	A	46999257	3	1	97	1	0	0	0	0	1	0	0	0	6730	1145	40	2	379	2	GPRIN2	10	46999257	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1078778	46999257	88535490	264	29752										
C10orf53	282966	broad.mit.edu	37	chr10	50916482	50916482	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcaccagcttagcagcccgtGtaggatgaaagtttctcctt	9	11	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:50916482G>C	uc001jid.1	+	3	353	c.293G>C	c.(292-294)TGT>TCT	p.C98S		NM_182554	NP_872360	Q8N6V4	CJ053_HUMAN	chromosome 10 open reading frame 53 isoform a	Error:Variant_position_missing_in_Q8N6V4_after_alignment											0		all_neural(218;0.107)				agcagcccgtgtaggatgaaa	0													0	0	0	0.00361	0	65	151										C	50916482	G	C	50916482	3	2	97	1	0	0	0	0	1	0	0	0	1606	1377	48	4	372	4	C10orf53	10	50916482	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3917225	50916482	84618265	265	29753										
HK1	3098	broad.mit.edu	37	chr10	71129055	71129055	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggcaccatgatgacctgtggCtatgacgaccagcactgtga	12	11	0	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:71129055C>T	uc001jpl.3	+	6	755	c.654C>T	c.(652-654)GGC>GGT	p.G218G	HK1_uc001jpg.3_Silent_p.G206G|HK1_uc001jph.3_Silent_p.G222G|HK1_uc001jpi.3_Silent_p.G222G|HK1_uc001jpj.3_Silent_p.G253G|HK1_uc001jpk.3_Silent_p.G217G|HK1_uc009xqd.2_Silent_p.G96G	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	218	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						TGACCTGTGGCTATGACGACC	0.537													0	0	0	0.002299	0	18	58										T	71129055	C	T	71129055	2	4	97	1	0	0	0	0	0	0	0	1	7190	784	28	2		2	HK1	10	71129055	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	20212573	71129055	64405692	266	29754										
CAMK2G	818	broad.mit.edu	37	chr10	75609037	75609037	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accttcaggtccctgtggacGatgtcatgctggtggatgtg	14	9	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:75609037G>A	uc001jvv.1	-	6	496	c.372C>T	c.(370-372)ATC>ATT	p.I124I	CAMK2G_uc001jvm.1_Silent_p.I132I|CAMK2G_uc001jvo.1_Silent_p.I132I|CAMK2G_uc001jvq.1_Silent_p.I132I|CAMK2G_uc001jvr.1_Silent_p.I132I|CAMK2G_uc001jvp.1_Silent_p.I132I|CAMK2G_uc001jvs.1_Silent_p.I132I|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Silent_p.I110I|CAMK2G_uc010qkv.1_Intron	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	132	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CCCTGTGGACGATGTCATGCT	0.522											OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	11	40										A	75609037	G	A	75609037	2	1	97	1	0	0	0	0	0	0	0	1	2602	1048	37	1		1	CAMK2G	10	75609037	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4479982	75609037	59925710	267	29755										
PIK3AP1	118788	broad.mit.edu	37	chr10	98380234	98380234	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctggagggtgataagctgccGctggcctggcgttttcattc	14	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:98380234G>A	uc001kmq.2	-	12	1944	c.1816C>T	c.(1816-1818)CGG>TGG	p.R606W	PIK3AP1_uc001kmo.2_Missense_Mutation_p.R205W|PIK3AP1_uc001kmp.2_Missense_Mutation_p.R428W	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	606						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		ATAAGCTGCCGCTGGCCTGGC	0.562													0	0	0	0.00361	0	54	77										A	98380234	G	A	98380234	3	1	97	1	0	0	0	0	1	0	0	0	11908	1086	38	2	625	2	PIK3AP1	10	98380234	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	22771197	98380234	37154513	268	29756										
CHUK	1147	broad.mit.edu	37	chr10	101953102	101953102	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agagaatgatcatgttctgcTgaagtcgggggcagccatgc	14	8	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:101953102T>G	uc001kqp.2	-	19	2116	c.2061A>C	c.(2059-2061)TCA>TCC	p.S687S		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	687				TS -> DL (in Ref. 7; AAC50713).	I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CATGTTCTGCTGAAGTCGGGG	0.473													0	0	0	0.00623	0	39	95										G	101953102	T	G	101953102	2	3	97	1	0	0	0	0	0	0	0	1	3416	1567	55	5		5	CHUK	10	101953102	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	3572868	101953102	33581645	269	29757										
MGEA5	10724	broad.mit.edu	37	chr10	103558904	103558904	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttcagctatgctctctttatCagtgtccattggtttcaatt	6	9	4	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:103558904C>T	uc001ktv.2	-	9	1947	c.1504G>A	c.(1504-1506)GAT>AAT	p.D502N	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.D449N|MGEA5_uc009xws.2_Missense_Mutation_p.D449N|MGEA5_uc001ktw.2_Missense_Mutation_p.D502N|MGEA5_uc009xwt.2_Missense_Mutation_p.D265N	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	502					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		CTCTCTTTATCAGTGTCCATT	0.398													0	0	0	0.00361	0	96	287										T	103558904	C	T	103558904	3	4	97	1	0	0	0	0	1	0	0	0	9555	826	29	1	1278	1	MGEA5	10	103558904	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1605802	103558904	31975843	270	29758										
NT5C2	22978	broad.mit.edu	37	chr10	104858711	104858711	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttgactacatacttctcaaGattttcaactgtcttttcct	3	10	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:104858711G>T	uc001kwo.2	-	10	850	c.664C>A	c.(664-666)CTT>ATT	p.L222I	NT5C2_uc010qqp.1_Missense_Mutation_p.L193I|NT5C2_uc001kwq.2_Missense_Mutation_p.L222I|NT5C2_uc001kwp.2_Missense_Mutation_p.L69I	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	222					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)	TACTTCTCAAGATTTTCAACT	0.294													1	0	9.70103e-10	0.008291	1.21889e-09	9	27										T	104858711	G	T	104858711	3	4	97	1	0	0	0	0	1	0	0	0	10687	942	33	3	1061	3	NT5C2	10	104858711	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1299807	104858711	30676036	271	29759										
PCGF6	84108	broad.mit.edu	37	chr10	105110683	105110683	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggagcccccgtctcagacagAggcgccggtccctcctcacc	11	19	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:105110683A>C	uc001kwt.2	-	1	209	c.141T>G	c.(139-141)CCT>CCG	p.P47P	PCGF6_uc001kwu.2_Silent_p.P47P|PCGF6_uc009xxk.2_RNA|PCGF6_uc009xxl.2_RNA|PCGF6_uc009xxm.2_RNA	NM_001011663	NP_001011663	Q9BYE7	PCGF6_HUMAN	polycomb group ring finger 6 isoform a	47	Pro-rich.				negative regulation of transcription, DNA-dependent	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)	1		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;2.57e-09)|all cancers(201;7.21e-08)|BRCA - Breast invasive adenocarcinoma(275;0.205)		TCTCAGACAGAGGCGCCGGTC	0.522													0	0	0	0.000602	0	5	9										C	105110683	A	C	105110683	2	2	97	1	0	0	0	0	0	0	0	1	11578	291	11	5		5	PCGF6	10	105110683	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	251972	105110683	30424064	272	29760										
SLK	9748	broad.mit.edu	37	chr10	105727602	105727619	+	In_Frame_Del	DEL	TTGGGAGATTATAGGAGA	TTGGGAGATTATAGGAGA	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gacctgaaccccgaagacttTtgggagattataggagaact					rs149480041		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:105727602_105727619delTTGGGAGATTATAGGAGA	uc001kxo.1	+	1	133_150	c.99_116delTTGGGAGATTATAGGAGA	c.(97-117)TTTTGGGAGATTATAGGAGAA>TTA	p.33_39FWEIIGE>L	SLK_uc001kxp.1_In_Frame_Del_p.33_39FWEIIGE>L	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	33_39	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CCGAAGACTTTTGGGAGATTATAGGAGAACTGGGCGAC	0.5																		11	99	---	---								-	105727619	TTGGGAGATTATAGGAGA	-	105727602	7	5	97	1	0	1	0	1	0	0	0	0	14748	1838	64	0	101	0	SLK	10	105727602	In_Frame_Del	DEL	TTGGGAGATTATAGGAGA	TCGA-G2-A2ES-01A-11D-A17V-08	616919	105727602	29807145	273	29761										
PNLIPRP3	119548	broad.mit.edu	37	chr10	118187433	118187433	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaacattgagttgcatcattGtgaggaaaaccacttagtat	8	6	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:118187433G>A	uc001lcl.3	+	1	10	c.-91G>A	c.(-93--89)TTGTG>TTATG			NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor						lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TTGCATCATTGTGAGGAAAAC	0.323													0	0	0	0.001984	0	6	31										A	118187433	G	A	118187433	1	1	97	1	0	0	0	0	0	0	0	0	12152	1392	48	2		2	PNLIPRP3	10	118187433	Translation_Start_Site	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	12459831	118187433	17347314	274	29762										
TACC2	10579	broad.mit.edu	37	chr10	123844863	123844863	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cactaggggagaagcggccaGagggagcatgcggtgatggt	19	7	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr10:123844863G>A	uc001lfv.2	+	4	3208	c.2848G>A	c.(2848-2850)GAG>AAG	p.E950K	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.E950K|TACC2_uc010qtv.1_Missense_Mutation_p.E950K	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	950						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GAAGCGGCCAGAGGGAGCATG	0.522													0	0	0	0.007835	0	39	109										A	123844863	G	A	123844863	3	1	97	1	0	0	0	0	1	0	0	0	15499	943	33	1	2858	1	TACC2	10	123844863	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5657430	123844863	11689884	275	29763										
C11orf35	256329	broad.mit.edu	37	chr11	556086	556086	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaggacgcgcgcagcggcttCttggcgctgcgggtcgcctc	17	14	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:556086C>T	uc001lpx.2	-	11	1350	c.1287G>A	c.(1285-1287)AAG>AAA	p.K429K	uc001lpy.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	429										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGCGGCTTCTTGGCGCTGC	0.587													0	0	0	0.006214	0	10	10										T	556086	C	T	556086	2	4	97	1	0	0	0	0	0	0	0	1	1638	912	32	1		1	C11orf35	11	556086	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08		556086	134450430	276	29764										
MUC15	143662	broad.mit.edu	37	chr11	26586972	26586972	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accaagtgaagttttctgaaGacagagcaggtgtagcattg	12	6	1	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:26586972G>A	uc001mqx.2	-	2	700	c.434C>T	c.(433-435)TCT>TTT	p.S145F	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.S172F|MUC15_uc001mqy.2_Missense_Mutation_p.S172F	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	145	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTTTCTGAAGACAGAGCAGG	0.428													0	0	0	0.004289	0	35	92										A	26586972	G	A	26586972	3	1	97	1	0	0	0	0	1	0	0	0	9972	942	33	1	582	1	MUC15	11	26586972	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	26030886	26586972	108419544	277	29765										
LIN7C	55327	broad.mit.edu	37	chr11	27523109	27523109	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagtctcatagacatgttcaTatacctgtaaaagccaaagt	6	9	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:27523109T>C	uc001mrl.2	-	3	188	c.161A>G	c.(160-162)TAT>TGT	p.Y54C	LIN7C_uc009yii.2_Intron	NM_018362	NP_060832	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C	54	L27.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction					0						GACATGTTCATATACCTGTAA	0.348													0	0	0	0.003271	0	33	56										C	27523109	T	C	27523109	3	2	97	1	0	0	0	0	1	0	0	0	8812	1406	49	5	444	5	LIN7C	11	27523109	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	936137	27523109	107483407	278	29766										
TCP11L1	55346	broad.mit.edu	37	chr11	33083105	33083105	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actttgtcacccagtggctgGaagaagcctcagaggacctt	11	11	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:33083105G>C	uc001mud.2	+	7	1205	c.805G>C	c.(805-807)GAA>CAA	p.E269Q	TCP11L1_uc009yju.2_Missense_Mutation_p.E84Q|TCP11L1_uc010rei.1_Missense_Mutation_p.E269Q|TCP11L1_uc001mue.2_Missense_Mutation_p.E269Q|TCP11L1_uc001muf.1_RNA	NM_018393	NP_060863	Q9NUJ3	T11L1_HUMAN	t-complex 11 (mouse) like 1	269											0						CCAGTGGCTGGAAGAAGCCTC	0.527													0	0	0	0.001523	0	21	38										C	33083105	G	C	33083105	3	2	97	1	0	0	0	0	1	0	0	0	15711	1175	41	1	827	1	TCP11L1	11	33083105	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5559996	33083105	101923411	279	29767										
CAPRIN1	4076	broad.mit.edu	37	chr11	34110948	34110948	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggtcacctttgcagttcattCtgaatctagacttgctcagc	8	11	5	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:34110948C>G	uc001mvh.1	+	12	1427	c.1238C>G	c.(1237-1239)TCT>TGT	p.S413C	CAPRIN1_uc001mvg.2_Missense_Mutation_p.S413C|CAPRIN1_uc001mvi.2_Missense_Mutation_p.S413C|CAPRIN1_uc001mvj.1_Missense_Mutation_p.S332C	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	413					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				GCAGTTCATTCTGAATCTAGA	0.313													0	0	0	0.007291	0	26	49										G	34110948	C	G	34110948	3	3	97	1	0	0	0	0	1	0	0	0	2635	913	32	1	1280	1	CAPRIN1	11	34110948	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1027843	34110948	100895568	280	29768										
ALX4	60529	broad.mit.edu	37	chr11	44331236	44331236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggggcgtcttgcaggcgcctCgctgcaagtaaagatgcggt	16	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:44331236C>T	uc001myb.2	-	1	481	c.377G>A	c.(376-378)CGA>CAA	p.R126Q		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	126					hair follicle development						0						GCAGGCGCCTCGCTGCAAGTA	0.473													0	0	0	0.000602	0	5	15										T	44331236	C	T	44331236	3	4	97	1	0	0	0	0	1	0	0	0	558	884	31	1	874	1	ALX4	11	44331236	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10220288	44331236	90675280	281	29769										
AMBRA1	55626	broad.mit.edu	37	chr11	46563668	46563677	+	Frame_Shift_Del	DEL	CTCCAGCCTG	CTCCAGCCTG	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggactagcagagctgctcaaCtccagcctgctggagctggg							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:46563668_46563677delCTCCAGCCTG	uc010rgu.1	-	7	2250_2259	c.1890_1899delCAGGCTGGAG	c.(1888-1899)AGCAGGCTGGAGfs	p.S630fs	AMBRA1_uc010rgt.1_Frame_Shift_Del_p.S196fs|AMBRA1_uc009ylc.1_Frame_Shift_Del_p.S630fs|AMBRA1_uc001ncu.1_Frame_Shift_Del_p.S540fs|AMBRA1_uc001ncv.2_Frame_Shift_Del_p.S540fs|AMBRA1_uc001ncw.2_Frame_Shift_Del_p.S540fs|AMBRA1_uc001ncx.2_Frame_Shift_Del_p.S630fs	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	630_633	Ser-rich.				autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AGCTGCTCAACTCCAGCCTGCTGGAGCTGG	0.595																		7	64	---	---								-	46563677	CTCCAGCCTG	-	46563668	7	5	97	1	0	1	0	1	0	0	0	0	565	564	20	0	2045	0	AMBRA1	11	46563668	Frame_Shift_Del	DEL	CTCCAGCCTG	TCGA-G2-A2ES-01A-11D-A17V-08	2232432	46563668	88442848	282	29770										
LRP4	4038	broad.mit.edu	37	chr11	46895138	46895138	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgttgctgccgttcaggtcTgctcgccttggggagagccc	14	12	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:46895138T>C	uc001ndn.3	-	29	4382	c.4236A>G	c.(4234-4236)GCA>GCG	p.A1412A	uc001ndl.2_RNA	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1412	Extracellular (Potential).|LDL-receptor class B 16.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CGTTCAGGTCTGCTCGCCTTG	0.532													0	0	0	0.002522	0	42	94										C	46895138	T	C	46895138	2	2	97	1	0	0	0	0	0	0	0	1	8959	1567	55	5		5	LRP4	11	46895138	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	331470	46895138	88111378	283	29771										
DDB2	1643	broad.mit.edu	37	chr11	47237917	47237917	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aagatgtgactcagactgccTctgggtggggctggctggcc	16	10	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:47237917T>C	uc001neb.2	+	2	353	c.158T>C	c.(157-159)CTC>CCC	p.L53P	DDB2_uc001nec.2_RNA|DDB2_uc009yli.1_Missense_Mutation_p.L53P|DDB2_uc001ned.2_RNA|DDB2_uc001nee.2_Missense_Mutation_p.L53P|DDB2_uc001nef.2_Missense_Mutation_p.L39P|DDB2_uc001neg.2_5'UTR|DDB2_uc001neh.2_5'Flank	NM_000107	NP_000098	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2	53					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			kidney(2)|ovary(1)	3						TCAGACTGCCTCTGGGTGGGG	0.557			Mis|N			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.00361	0	50	148										C	47237917	T	C	47237917	3	2	97	1	0	0	0	0	1	0	0	0	4324	1551	54	5	164	5	DDB2	11	47237917	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	342779	47237917	87768599	284	29772										
OR5AS1	219447	broad.mit.edu	37	chr11	55798060	55798060	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttaatattaattcaagccttCaaattcccatgtattatttt	2	7	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:55798060C>T	uc010riw.1	+	1	166	c.166C>T	c.(166-168)CAA>TAA	p.Q56*		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TTCAAGCCTTCAAATTCCCAT	0.343													0	0	0	0.004007	0	15	55										T	55798060	C	T	55798060	4	4	97	1	0	0	0	0	0	1	0	0	11146	827	29	1	168	1	OR5AS1	11	55798060	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	8560143	55798060	79208456	285	29773										
MS4A2	2206	broad.mit.edu	37	chr11	59863129	59863129	+	Nonstop_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctcctcccattgatttataAgaatcacgtgtccagaacac	5	12	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:59863129A>C	uc001nop.2	+	7	837	c.735A>C	c.(733-735)TAA>TAC	p.*245Y		NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	245					cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	TTGATTTATAAGAATCACGTG	0.428													0	0	0	0.008291	0	10	30										C	59863129	A	C	59863129	4	2	97	1	0	0	0	0	0	0	0	0	9860	79	3	5	812	5	MS4A2	11	59863129	Nonstop_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	4065069	59863129	75143387	286	29774										
ZP1	22917	broad.mit.edu	37	chr11	60636673	60636673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccatctgctaccactgggtCacctccaggccgcaggagcc	10	17	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:60636673C>T	uc001nqd.2	+	2	272	c.252C>T	c.(250-252)GTC>GTT	p.V84V	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	84	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						ACCACTGGGTCACCTCCAGGC	0.587													0	0	0	0.002299	0	20	41										T	60636673	C	T	60636673	2	4	97	1	0	0	0	0	0	0	0	1	18212	813	29	1		1	ZP1	11	60636673	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	773544	60636673	74369843	287	29775										
CD5	921	broad.mit.edu	37	chr11	60889102	60889102	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggtttccagcccaaggtgcaGagccgtctggtggggggcag	18	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:60889102G>A	uc009ynk.2	+	6	928	c.825G>A	c.(823-825)CAG>CAA	p.Q275Q		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	275	Extracellular (Potential).				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CCAAGGTGCAGAGCCGTCTGG	0.637													0	0	0	0.00499	0	17	73										A	60889102	G	A	60889102	2	1	97	1	0	0	0	0	0	0	0	1	3021	933	33	1		1	CD5	11	60889102	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	252429	60889102	74117414	288	29776										
CAPN1	823	broad.mit.edu	37	chr11	64977856	64977856	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcatcatcacccgctactcGgagcccgacctggcggtcga	10	17	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:64977856G>A	uc009yqd.1	+	20	2103	c.1992G>A	c.(1990-1992)TCG>TCA	p.S664S	CAPN1_uc001odf.1_Silent_p.S664S|CAPN1_uc001odg.1_Silent_p.S664S|CAPN1_uc010roa.1_Silent_p.S405S	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	664	Domain IV.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		CCCGCTACTCGGAGCCCGACC	0.592													0	0	0	0.001855	0	12	21										A	64977856	G	A	64977856	2	1	97	1	0	0	0	0	0	0	0	1	2622	1103	39	2		2	CAPN1	11	64977856	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4088754	64977856	70028660	289	29777										
LRP5	4041	broad.mit.edu	37	chr11	68115341	68115341	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgctcctgctatttgccaacCgccgggacgtacggctggtg	13	14	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:68115341C>T	uc001ont.2	+	2	193	c.118C>T	c.(118-120)CGC>TGC	p.R40C	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	40	Beta-propeller 1.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ATTTGCCAACCGCCGGGACGT	0.632													0	0	0	0.003954	0	23	190										T	68115341	C	T	68115341	3	4	97	1	0	0	0	0	1	0	0	0	8960	652	23	2	124	2	LRP5	11	68115341	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3137485	68115341	66891175	290	29778										
NUMA1	4926	broad.mit.edu	37	chr11	71724518	71724518	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgtgctcgagctgcagggtgGagagggcctgctctttctgg	17	9	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:71724518G>A	uc001orl.1	-	15	4203	c.4031C>T	c.(4030-4032)TCC>TTC	p.S1344F	NUMA1_uc009ysw.1_Missense_Mutation_p.S907F|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Missense_Mutation_p.S1344F|NUMA1_uc001orn.2_Missense_Mutation_p.S907F|NUMA1_uc009ysx.1_Missense_Mutation_p.S1344F|NUMA1_uc001oro.1_Missense_Mutation_p.S1344F	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1344	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTGCAGGGTGGAGAGGGCCTG	0.647			T	RARA	APL								0	0	0	0.001368	0	12	125										A	71724518	G	A	71724518	3	1	97	1	0	0	0	0	1	0	0	0	10750	1174	41	1	2368	1	NUMA1	11	71724518	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3609177	71724518	63281998	291	29779										
INPPL1	3636	broad.mit.edu	37	chr11	71943351	71943351	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttggctttgtgaattgtcaCctcacctcgggaaatgagaa	10	8	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:71943351C>T	uc001osf.2	+	14	1830	c.1683C>T	c.(1681-1683)CAC>CAT	p.H561H	INPPL1_uc001osg.2_Silent_p.H319H	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	561					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						TGAATTGTCACCTCACCTCGG	0.552													0	0	0	0.000602	0	5	9										T	71943351	C	T	71943351	2	4	97	1	0	0	0	0	0	0	0	1	7761	506	18	2		2	INPPL1	11	71943351	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	218833	71943351	63063165	292	29780										
RSF1	51773	broad.mit.edu	37	chr11	77378038	77378038	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	catcttcctcctcttctggtGctcctgcctcctgcccacca	5	20	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:77378038G>C	uc001oyn.2	-	16	4370	c.4250C>G	c.(4249-4251)GCA>GGA	p.A1417G	RSF1_uc001oym.2_Missense_Mutation_p.A1165G	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1417					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			CTCTTCTGGTGCTCCTGCCTC	0.478													0	0	0	0.00361	0	44	282										C	77378038	G	C	77378038	3	2	97	1	0	0	0	0	1	0	0	0	13699	1319	46	4	79	4	RSF1	11	77378038	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5434687	77378038	57628478	293	29781										
ODZ4	26011	broad.mit.edu	37	chr11	78369287	78369287	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cttcctccccttcccgcagtCtctgctgctcgcgggcccac	8	21	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:78369287C>G	uc001ozl.3	-	34	8589	c.8126G>C	c.(8125-8127)AGA>ACA	p.R2709T	ODZ4_uc001ozk.3_Missense_Mutation_p.R934T|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2709	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TTCCCGCAGTCTCTGCTGCTC	0.667													0	0	0	0.001523	0	19	65										G	78369287	C	G	78369287	3	3	97	1	0	0	0	0	1	0	0	0	10837	913	32	1	187	1	ODZ4	11	78369287	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	991249	78369287	56637229	294	29782										
MRE11A	4361	broad.mit.edu	37	chr11	94201031	94201031	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagaattacccagacgttccCgttcagcattttcaagcatt	7	11	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:94201031C>A	uc001peu.2	-	10	1235	c.1046G>T	c.(1045-1047)CGG>CTG	p.R349L	MRE11A_uc001pev.2_Missense_Mutation_p.R349L|MRE11A_uc009ywj.2_Missense_Mutation_p.R352L|MIR548L_hsa-mir-548l|MI0006361_5'Flank	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1	349					DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				CAGACGTTCCCGTTCAGCATT	0.333								Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				1	0	1.32181e-22	0.007291	1.75715e-22	27	26										A	94201031	C	A	94201031	3	1	97	1	0	0	0	0	1	0	0	0	9759	652	23	4	1124	4	MRE11A	11	94201031	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	15831744	94201031	40805485	295	29783										
EXPH5	23086	broad.mit.edu	37	chr11	108464258	108464258	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcaaacgccggaggaactttCgtcattttctttactgtgtg	9	9	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:108464258C>T	uc001pkk.2	-	1	117	c.6G>A	c.(4-6)ACG>ACA	p.T2T		NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	2					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GAGGAACTTTCGTCATTTTCT	0.458													0	0	0	0.00499	0	17	38										T	108464258	C	T	108464258	2	4	97	1	0	0	0	0	0	0	0	1	5322	871	31	1		1	EXPH5	11	108464258	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	14263227	108464258	26542258	296	29784										
HTR3B	9177	broad.mit.edu	37	chr11	113775663	113775663	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gatctgcccaggaatgttgtCaagtgtaatggctcccctgt	11	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:113775663C>G	uc001pok.2	+	1	75	c.8C>G	c.(7-9)TCA>TGA	p.S3*		NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	3					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GGAATGTTGTCAAGTGTAATG	0.458													0	0	0	0.00499	0	14	32										G	113775663	C	G	113775663	4	3	97	1	0	0	0	0	0	1	0	0	7445	838	29	1	10	1	HTR3B	11	113775663	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5311405	113775663	21230853	297	29785										
GRIK4	2900	broad.mit.edu	37	chr11	120690613	120690613	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcaccaccgcctgcctcatCtgtgccaaagcagaatgtaa	8	14	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:120690613C>T	uc001pxn.2	+	6	782	c.495C>T	c.(493-495)ATC>ATT	p.I165I	GRIK4_uc009zav.1_Silent_p.I165I|GRIK4_uc009zaw.1_Silent_p.I165I|GRIK4_uc009zax.1_Silent_p.I165I	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	165	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CCTGCCTCATCTGTGCCAAAG	0.557													0	0	0	0.00361	0	88	150										T	120690613	C	T	120690613	2	4	97	1	0	0	0	0	0	0	0	1	6776	903	32	1		1	GRIK4	11	120690613	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	6914950	120690613	14315903	298	29786										
HSPA8	3312	broad.mit.edu	37	chr11	122929535	122929535	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	catggcacgctcgccttcatAaaccttggtaggaaataaaa	8	10	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:122929535A>G	uc001pyo.2	-	7	1405	c.1327T>C	c.(1327-1329)TAT>CAT	p.Y443H	HSPA8_uc009zbc.2_Missense_Mutation_p.Y207H|HSPA8_uc001pyp.2_Missense_Mutation_p.Y443H|HSPA8_uc010rzu.1_Missense_Mutation_p.Y366H	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	443					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TCGCCTTCATAAACCTTGGTA	0.428													0	0	0	0.006122	0	18	34										G	122929535	A	G	122929535	3	3	97	1	0	0	0	0	1	0	0	0	7416	362	13	5	625	5	HSPA8	11	122929535	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2238922	122929535	12076981	299	29787										
OR6M1	390261	broad.mit.edu	37	chr11	123676311	123676311	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tacacaaagatgttgctcccGtgggcaatggagacaacagt	11	9	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr11:123676311G>A	uc010rzz.1	-	1	747	c.747C>T	c.(745-747)CAC>CAT	p.H249H		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		TGTTGCTCCCGTGGGCAATGG	0.507													0	0	0	0.001368	0	13	28										A	123676311	G	A	123676311	2	1	97	1	0	0	0	0	0	0	0	1	11205	1136	40	2		2	OR6M1	11	123676311	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	746776	123676311	11330205	300	29788										
IQSEC3	440073	broad.mit.edu	37	chr12	278230	278230	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actctccttcaagccctgcgGagcccagggggacccacagt	11	16	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:278230G>A	uc001qhw.1	+	9	2120	c.2114G>A	c.(2113-2115)GGA>GAA	p.G705E	IQSEC3_uc001qhu.1_Missense_Mutation_p.G705E	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1008					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		AAGCCCTGCGGAGCCCAGGGG	0.622													0	0	0	0.003214	0	44	104										A	278230	G	A	278230	3	1	97	1	0	0	0	0	1	0	0	0	7819	1174	41	1	3069	1	IQSEC3	12	278230	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		278230	133573665	301	29789										
RAD51AP1	10635	broad.mit.edu	37	chr12	4662181	4662181	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggatgattctgatttttgtGagagtgaggataatgacgaa	13	2	1	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:4662181G>A	uc001qmw.2	+	8	796	c.640G>A	c.(640-642)GAG>AAG	p.E214K	RAD51AP1_uc001qmu.2_Missense_Mutation_p.E197K|RAD51AP1_uc001qmv.2_Missense_Mutation_p.E160K|RAD51AP1_uc010sep.1_Missense_Mutation_p.E79K|RAD51AP1_uc010seq.1_Missense_Mutation_p.E79K|RAD51AP1_uc009zeg.2_RNA	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	214					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			TGATTTTTGTGAGAGTGAGGA	0.318													0	0	0	0.006122	0	17	53										A	4662181	G	A	4662181	3	1	97	1	0	0	0	0	1	0	0	0	12986	1291	45	1	670	1	RAD51AP1	12	4662181	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4383951	4662181	129189714	302	29790										
VWF	7450	broad.mit.edu	37	chr12	6128469	6128469	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggaggcttcagggcggtcgAtcttgctgaagatttggaac	16	7	2	2	rs61750070		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:6128469A>G	uc001qnn.1	-	28	4365	c.4115T>C	c.(4114-4116)ATC>ACC	p.I1372T	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1372	VWFA 1; binding site for platelet glycoprotein Ib.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	AGGGCGGTCGATCTTGCTGAA	0.612													0	0	0	0.003271	0	34	85										G	6128469	A	G	6128469	3	3	97	1	0	0	0	0	1	0	0	0	17243	333	12	5	4426	5	VWF	12	6128469	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1466288	6128469	127723426	303	29791										
PLEKHG6	55200	broad.mit.edu	37	chr12	6436472	6436472	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggtggtgacagaagacacaGatgaagatgctccccttgtg	13	8	0	6			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:6436472G>T	uc001qnr.2	+	15	1871	c.1723G>T	c.(1723-1725)GAT>TAT	p.D575Y	PLEKHG6_uc010sew.1_Missense_Mutation_p.D575Y|PLEKHG6_uc010sex.1_Missense_Mutation_p.D543Y	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	575					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						AGAAGACACAGATGAAGATGC	0.552											OREG0021622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.85841e-42	0.00361	5.24556e-42	54	159										T	6436472	G	T	6436472	3	4	97	1	0	0	0	0	1	0	0	0	12074	942	33	3	1823	3	PLEKHG6	12	6436472	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	308003	6436472	127415423	304	29792										
ARHGDIB	397	broad.mit.edu	37	chr12	15100819	15100819	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atacttactttgaagtgaatTttgactctatattcagaacc	5	7	2	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:15100819T>C	uc001rcq.1	-	4	434	c.330A>G	c.(328-330)AAA>AAG	p.K110K	ARHGDIB_uc001rcp.1_RNA	NM_001175	NP_001166	P52566	GDIR2_HUMAN	Rho GDP dissociation inhibitor (GDI) beta	110					actin cytoskeleton organization|cellular component movement|immune response|multicellular organismal development|negative regulation of cell adhesion|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoplasmic membrane-bounded vesicle|cytoskeleton|cytosol	GTPase activator activity|Rho GDP-dissociation inhibitor activity				0						TGAAGTGAATTTTGACTCTAT	0.343													0	0	0	0.008361	0	29	72										C	15100819	T	C	15100819	2	2	97	1	0	0	0	0	0	0	0	1	891	1838	64	5		5	ARHGDIB	12	15100819	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	8664347	15100819	118751076	305	29793										
ITPR2	3709	broad.mit.edu	37	chr12	26810951	26810951	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tatctgggcttacttagtttGaatgagaatgtctgcattgc	10	6	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:26810951G>A	uc001rhg.2	-	17	2416	c.1999C>T	c.(1999-2001)CAA>TAA	p.Q667*		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	667	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TACTTAGTTTGAATGAGAATG	0.348													0	0	0	0.00632	0	28	68										A	26810951	G	A	26810951	4	1	97	1	0	0	0	0	0	1	0	0	7921	1299	45	1	6270	1	ITPR2	12	26810951	Nonsense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	11710132	26810951	107040944	306	29794										
PUS7L	83448	broad.mit.edu	37	chr12	44148459	44148459	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tatattcaagatttggttttAcaacaatttcactgtttttt	4	5	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:44148459A>T	uc001rnq.3	-	2	1079	c.590T>A	c.(589-591)GTA>GAA	p.V197E	PUS7L_uc001rnr.3_Missense_Mutation_p.V197E|PUS7L_uc001rns.3_Missense_Mutation_p.V197E|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	197					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		ATTTGGTTTTACAACAATTTC	0.323													0	0	0	0.007291	0	30	73										T	44148459	A	T	44148459	3	4	97	1	0	0	0	0	1	0	0	0	12834	391	14	5	1547	5	PUS7L	12	44148459	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	17337508	44148459	89703436	307	29795										
DDN	23109	broad.mit.edu	37	chr12	49392962	49392962	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acaggaaatagtcttcacttCtatcaccaatagcttggact	6	10	4	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:49392962C>A	uc001rsv.1	-	1	127	c.109G>T	c.(109-111)GAA>TAA	p.E37*	uc001rsw.2_Intron	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	37						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						GTCTTCACTTCTATCACCAAT	0.607													1	0	4.7546e-09	0.004007	5.94516e-09	16	30										A	49392962	C	A	49392962	4	1	97	1	0	0	0	0	0	1	0	0	4333	922	32	3	2034	3	DDN	12	49392962	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5244503	49392962	84458933	308	29796										
KRT18	3875	broad.mit.edu	37	chr12	53345517	53345517	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actgtccccatcctgcagatTgaggagagcaccacagtggt	11	12	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:53345517T>G	uc001sbe.2	+	6	894	c.825T>G	c.(823-825)ATT>ATG	p.I275M	KRT18_uc009zmn.1_Missense_Mutation_p.I275M|KRT18_uc001sbf.1_Missense_Mutation_p.I102M|KRT18_uc001sbg.2_Missense_Mutation_p.I275M|KRT18_uc009zmo.2_Missense_Mutation_p.I275M|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	275	Interaction with DNAJB6.|Coil 2.|Rod.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						TCCTGCAGATTGAGGAGAGCA	0.607													0	0	0	0.00308	0	8	38										G	53345517	T	G	53345517	3	3	97	1	0	0	0	0	1	0	0	0	8455	1800	63	5	843	5	KRT18	12	53345517	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	3952555	53345517	80506378	309	29797										
PFDN5	5204	broad.mit.edu	37	chr12	53689715	53689715	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgtctgaacgtgctgaacaaGagcaacgagggtatggggta	15	6	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:53689715G>A	uc001scl.2	+	2	282	c.165G>A	c.(163-165)AAG>AAA	p.K55K	PFDN5_uc001scm.2_Intron|PFDN5_uc001scn.2_RNA|PFDN5_uc001sco.2_RNA	NM_002624	NP_002615	Q99471	PFD5_HUMAN	prefoldin subunit 5 isoform alpha	55					'de novo' posttranslational protein folding|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent	nucleus|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)	1						TGCTGAACAAGAGCAACGAGG	0.517													0	0	0	0.001882	0	18	32										A	53689715	G	A	53689715	2	1	97	1	0	0	0	0	0	0	0	1	11758	933	33	1		1	PFDN5	12	53689715	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	344198	53689715	80162180	310	29798										
ATP5B	506	broad.mit.edu	37	chr12	57037667	57037667	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctagcagatcgacaaccttGataccagtcaccagaatttc	7	12	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:57037667G>A	uc001slr.2	-	4	666	c.561C>T	c.(559-561)ATC>ATT	p.I187I	SNORD59B_uc001sls.1_5'Flank	NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	187					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						CGACAACCTTGATACCAGTCA	0.428													0	0	0	0.001882	0	21	73										A	57037667	G	A	57037667	2	1	97	1	0	0	0	0	0	0	0	1	1148	1280	45	1		1	ATP5B	12	57037667	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3347952	57037667	76814228	311	29799										
FAM119B	25895	broad.mit.edu	37	chr12	58174278	58174278	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caggccccatggcaccatctAtctggcctccaagatgagaa	9	14	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:58174278A>G	uc001sqg.2	+	3	655	c.530A>G	c.(529-531)TAT>TGT	p.Y177C	FAM119B_uc001sqf.2_3'UTR|FAM119B_uc009zqd.2_RNA|TSFM_uc001sqi.2_5'Flank|TSFM_uc010sse.1_5'Flank|TSFM_uc001sqh.2_5'Flank|TSFM_uc010ssf.1_5'Flank	NM_015433	NP_056248	Q96AZ1	MT21B_HUMAN	hypothetical protein LOC25895 isoform a	177						integral to membrane|intracellular	methyltransferase activity				0	all_cancers(7;9.07e-82)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					GGCACCATCTATCTGGCCTCC	0.582													0	0	0	0.00278	0	24	40										G	58174278	A	G	58174278	3	3	97	1	0	0	0	0	1	0	0	0	5414	449	16	5	683	5	FAM119B	12	58174278	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1136611	58174278	75677617	312	29800										
GNS	2799	broad.mit.edu	37	chr12	65116858	65116858	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctccttggtattccaccagGacatctgatcgccaggtcaa	8	13	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:65116858G>T	uc001ssg.3	-	11	1406	c.1236C>A	c.(1234-1236)GTC>GTA	p.V412V	GNS_uc001ssf.2_Silent_p.V356V|GNS_uc010ssq.1_Silent_p.V444V|GNS_uc010ssr.1_Silent_p.V392V	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	412						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		ATTCCACCAGGACATCTGATC	0.453													1	0	9.8876e-21	0.004878	1.30771e-20	33	82										T	65116858	G	T	65116858	2	4	97	1	0	0	0	0	0	0	0	1	6550	1161	41	3		3	GNS	12	65116858	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	6942580	65116858	68735037	313	29801										
PPP1R12A	4659	broad.mit.edu	37	chr12	80202350	80202350	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caagcctagttcctttactaTctttctcctacacaacaggg	5	13	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:80202350T>C	uc001syz.2	-	11	1730	c.1463A>G	c.(1462-1464)GAT>GGT	p.D488G	PPP1R12A_uc010suc.1_Missense_Mutation_p.D401G|PPP1R12A_uc001sza.2_Missense_Mutation_p.D488G|PPP1R12A_uc010sud.1_Missense_Mutation_p.D488G|PPP1R12A_uc001szb.2_Missense_Mutation_p.D488G|PPP1R12A_uc001szc.2_Missense_Mutation_p.D488G	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	488						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						TCCTTTACTATCTTTCTCCTA	0.323													0	0	0	0.002852	0	42	135										C	80202350	T	C	80202350	3	2	97	1	0	0	0	0	1	0	0	0	12354	1435	50	5	1689	5	PPP1R12A	12	80202350	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	15085492	80202350	53649545	314	29802										
APAF1	317	broad.mit.edu	37	chr12	99120994	99120994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcttcttcatttgtgtgctcCgctttcagaagaaggagctg	11	9	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:99120994C>T	uc001tfz.2	+	26	4077	c.3500C>T	c.(3499-3501)CCG>CTG	p.P1167L	APAF1_uc001tfy.2_Missense_Mutation_p.P1156L|APAF1_uc001tga.2_Missense_Mutation_p.P1113L|APAF1_uc001tgb.2_Missense_Mutation_p.P1124L|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Missense_Mutation_p.P491L	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	1167					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TTGTGTGCTCCGCTTTCAGAA	0.423													0	0	0	0.004656	0	28	138										T	99120994	C	T	99120994	3	4	97	1	0	0	0	0	1	0	0	0	755	652	23	2	3598	2	APAF1	12	99120994	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	18918644	99120994	34730901	315	29803										
ANKS1B	56899	broad.mit.edu	37	chr12	100377915	100377915	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acaggggcaggggtccggatCcaccgcccaggatccctcct	13	16	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:100377915C>T	uc001tge.1	-	1	518	c.101G>A	c.(100-102)GGA>GAA	p.G34E	ANKS1B_uc001tgf.1_5'UTR|ANKS1B_uc009ztt.1_Missense_Mutation_p.G34E	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	34						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GGGTCCGGATCCACCGCCCAG	0.582													0	0	0	0.00333	0	23	78										T	100377915	C	T	100377915	3	4	97	1	0	0	0	0	1	0	0	0	689	855	30	1	4037	1	ANKS1B	12	100377915	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1256921	100377915	33473980	316	29804										
ANKS1B	56899	broad.mit.edu	37	chr12	100378001	100378001	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgagcagcttccagcagctcCtggtccttccccatagtctc	8	17	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:100378001C>T	uc001tge.1	-	1	432	c.15G>A	c.(13-15)CAG>CAA	p.Q5Q	ANKS1B_uc001tgf.1_5'UTR|ANKS1B_uc009ztt.1_Silent_p.Q5Q	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	5	ANK 1.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CCAGCAGCTCCTGGTCCTTCC	0.642													0	0	0	0.00245	0	13	47										T	100378001	C	T	100378001	2	4	97	1	0	0	0	0	0	0	0	1	689	680	24	2		2	ANKS1B	12	100378001	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	86	100378001	33473894	317	29805										
C12orf48	55010	broad.mit.edu	37	chr12	102569339	102569339	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcagggatcctttttgcaaAgcaatagaggaagttgctca	11	7	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:102569339A>G	uc001tjf.2	+	7	1012	c.900A>G	c.(898-900)AAA>AAG	p.K300K	C12orf48_uc001tjg.2_Silent_p.K219K|C12orf48_uc010swa.1_Silent_p.K377K|C12orf48_uc001tjh.2_Silent_p.K219K|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Silent_p.K15K|C12orf48_uc001tjk.2_Intron|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	300					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						CTTTTTGCAAAGCAATAGAGG	0.388													0	0	0	0.00632	0	30	79										G	102569339	A	G	102569339	2	3	97	1	0	0	0	0	0	0	0	1	1692	69	3	5		5	C12orf48	12	102569339	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2191338	102569339	31282556	318	29806										
KIAA1033	23325	broad.mit.edu	37	chr12	105558026	105558026	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgtacagtcagccagtcaaGatgaaaaactcttacaaacc	6	10	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:105558026G>A	uc001tld.2	+	31	3382	c.3295G>A	c.(3295-3297)GAT>AAT	p.D1099N	KIAA1033_uc010swr.1_Missense_Mutation_p.D1100N|KIAA1033_uc010sws.1_Missense_Mutation_p.D911N	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	1099					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						AGCCAGTCAAGATGAAAAACT	0.428													0	0	0	0.002836	0	33	74										A	105558026	G	A	105558026	3	1	97	1	0	0	0	0	1	0	0	0	8206	942	33	1	3417	1	KIAA1033	12	105558026	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2988687	105558026	28293869	319	29807										
TCHP	84260	broad.mit.edu	37	chr12	110342545	110342545	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgtgttttcttgatagattGctgaacaacttttgtacgaa	8	5	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:110342545G>T	uc001tpn.2	+	4	556	c.403G>T	c.(403-405)GCT>TCT	p.A135S	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Missense_Mutation_p.A135S	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	135	Glu-rich.|Potential.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						TTGATAGATTGCTGAACAACT	0.373													1	0	2.94398e-08	0.007413	3.66352e-08	18	48										T	110342545	G	T	110342545	3	4	97	1	0	0	0	0	1	0	0	0	15699	1319	46	4	413	4	TCHP	12	110342545	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4784519	110342545	23509350	320	29808										
TCHP	84260	broad.mit.edu	37	chr12	110345365	110345365	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agagcaagagaacaaacggtAtgaaaatgaatatgaaaggg	12	3	0	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:110345365A>T	uc001tpn.2	+	6	713	c.560A>T	c.(559-561)TAT>TTT	p.Y187F	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Missense_Mutation_p.Y187F	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	187	Glu-rich.|Interaction with keratin proteins.|Potential.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						AACAAACGGTATGAAAATGAA	0.507													0	0	0	0.007291	0	28	83										T	110345365	A	T	110345365	3	4	97	1	0	0	0	0	1	0	0	0	15699	449	16	5	578	5	TCHP	12	110345365	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2820	110345365	23506530	321	29809										
IFT81	28981	broad.mit.edu	37	chr12	110643412	110643412	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctatttagaacctagaagttCaacttcgtcgtgctactgat	7	9	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:110643412C>G	uc001tqi.2	+	17	1859	c.1729C>G	c.(1729-1731)CAA>GAA	p.Q577E	IFT81_uc001tqh.2_Missense_Mutation_p.Q577E|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	577	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						CCTAGAAGTTCAACTTCGTCG	0.318													0	0	0	0.00361	0	64	192										G	110643412	C	G	110643412	3	3	97	1	0	0	0	0	1	0	0	0	7565	827	29	1	1903	1	IFT81	12	110643412	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	298047	110643412	23208483	322	29810										
C12orf24	29902	broad.mit.edu	37	chr12	110927913	110927913	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcaatcaatgtcaattgaaGaacagggagaacatctgatg	10	6	3	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:110927913G>A	uc001tqu.3	+	7	1242	c.793G>A	c.(793-795)GAA>AAA	p.E265K	C12orf24_uc001tqv.3_RNA|C12orf24_uc009zvp.2_RNA	NM_013300	NP_037432	Q8WUB2	CL024_HUMAN	hypothetical protein LOC29902	265											0						GTCAATTGAAGAACAGGGAGA	0.363													0	0	0	0.005524	0	36	105										A	110927913	G	A	110927913	3	1	97	1	0	0	0	0	1	0	0	0	1678	943	33	1	819	1	C12orf24	12	110927913	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	284501	110927913	22923982	323	29811										
BRAP	8315	broad.mit.edu	37	chr12	112097074	112097074	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atacgtgtgctgcgtttcctCaaagtgcttataagcatgtc	9	9	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:112097074C>T	uc001tsn.3	-	8	1242	c.1048G>A	c.(1048-1050)GAG>AAG	p.E350K	BRAP_uc010syh.1_Missense_Mutation_p.E171K|BRAP_uc009zvv.2_Missense_Mutation_p.E320K	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	350	UBP-type.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						TGCGTTTCCTCAAAGTGCTTA	0.443													0	0	0	0.003271	0	33	108										T	112097074	C	T	112097074	3	4	97	1	0	0	0	0	1	0	0	0	1497	835	29	1	750	1	BRAP	12	112097074	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1169161	112097074	21754821	324	29812										
RBM19	9904	broad.mit.edu	37	chr12	114358488	114358488	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aatccaaaccccatggaaagGagcactcctgagagagagag	11	10	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:114358488G>C	uc009zwi.2	-	19	2457	c.2313C>G	c.(2311-2313)CTC>CTG	p.L771L	RBM19_uc001tvn.3_Silent_p.L771L|RBM19_uc001tvm.2_Silent_p.L771L	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	771	RRM 5.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CCATGGAAAGGAGCACTCCTG	0.507													0	0	0	0.00361	0	110	249										C	114358488	G	C	114358488	2	2	97	1	0	0	0	0	0	0	0	1	13121	1161	41	1		1	RBM19	12	114358488	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2261414	114358488	19493407	325	29813										
EP400	57634	broad.mit.edu	37	chr12	132547111	132547111	+	Silent	SNP	G	G	A													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caacagcagcagcagcagcaGcagcagcagcagcagcagca							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:132547111G>A	uc001ujn.2	+	46	8234	c.8199G>A	c.(8197-8199)CAG>CAA	p.Q2733Q	EP400_uc001ujl.2_Silent_p.Q2732Q|EP400_uc001ujm.2_Silent_p.Q2652Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2769	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcagcagcagc	0.323													0	0	0	0.008291	0	10	72										A	132547111	G	A	132547111	2	1	97	1	0	0	0	0	0	0	0	1	5149	962	34	2		2	EP400	12	132547111	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	18188623	132547111	1304784	326	29814	151	3								
EP400	57634	broad.mit.edu	37	chr12	132547117	132547117	+	Silent	SNP	G	G	A													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcagcagcagcagcagcaGcagcagcagcagcagcagca					rs151326088		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:132547117G>A	uc001ujn.2	+	46	8240	c.8205G>A	c.(8203-8205)CAG>CAA	p.Q2735Q	EP400_uc001ujl.2_Silent_p.Q2734Q|EP400_uc001ujm.2_Silent_p.Q2654Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2771	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcagcagcagc	0.323													0	0	0	0.004482	0	9	64										A	132547117	G	A	132547117	2	1	97	1	0	0	0	0	0	0	0	1	5149	962	34	2		2	EP400	12	132547117	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	6	132547117	1304778	327	29815	151	3								
EP400	57634	broad.mit.edu	37	chr12	132547120	132547120	+	Silent	SNP	G	G	A													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcagcagcagcagcagcaGcagcagcagcagcagcaaca							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:132547120G>A	uc001ujn.2	+	46	8243	c.8208G>A	c.(8206-8208)CAG>CAA	p.Q2736Q	EP400_uc001ujl.2_Silent_p.Q2735Q|EP400_uc001ujm.2_Silent_p.Q2655Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2772	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcagcagcagc	0.318													0	0	0	0.008291	0	11	65										A	132547120	G	A	132547120	2	1	97	1	0	0	0	0	0	0	0	1	5149	962	34	2		2	EP400	12	132547120	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3	132547120	1304775	328	29816	151	3								
GOLGA3	2802	broad.mit.edu	37	chr12	133381318	133381318	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcacctgtgttgtccttgctGagcatgctcctctgcatgtc	9	13	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr12:133381318G>A	uc001ukz.1	-	7	2140	c.1581C>T	c.(1579-1581)CTC>CTT	p.L527L	GOLGA3_uc001ula.1_Silent_p.L527L|GOLGA3_uc001ulb.2_Silent_p.L527L	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	527	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TGTCCTTGCTGAGCATGCTCC	0.637													0	0	0	0.008361	0	28	68										A	133381318	G	A	133381318	2	1	97	1	0	0	0	0	0	0	0	1	6554	1277	45	1		1	GOLGA3	12	133381318	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	834198	133381318	470577	329	29817										
SMAD9	4093	broad.mit.edu	37	chr13	37422860	37422860	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggagagcccatctgagtcaGaactttgtccagccactgca	10	12	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr13:37422860G>C	uc001uvw.2	-	7	1700	c.1357C>G	c.(1357-1359)CTG>GTG	p.L453V	SMAD9_uc001uvx.2_Missense_Mutation_p.L416V|SMAD9_uc010tep.1_Missense_Mutation_p.L246V	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	453	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		ATCTGAGTCAGAACTTTGTCC	0.507													0	0	0	0.00361	0	97	188										C	37422860	G	C	37422860	3	2	97	1	0	0	0	0	1	0	0	0	14764	933	33	1	50	1	SMAD9	13	37422860	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		37422860	77747018	330	29818										
FREM2	341640	broad.mit.edu	37	chr13	39263139	39263139	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtttctgttccccatcacctTagtgcctgtggatgaccagc	9	13	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr13:39263139T>C	uc001uwv.2	+	1	1967	c.1658T>C	c.(1657-1659)TTA>TCA	p.L553S		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	553	CSPG 3.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CCCATCACCTTAGTGCCTGTG	0.582													0	0	0	0.001368	0	13	21										C	39263139	T	C	39263139	3	2	97	1	0	0	0	0	1	0	0	0	6045	1764	61	5	1660	5	FREM2	13	39263139	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1840279	39263139	75906739	331	29819										
DIAPH3	81624	broad.mit.edu	37	chr13	60240843	60240843	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	attacacgcttccttcttctCagctgccttgatcctcccag	5	16	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr13:60240843C>T	uc001vht.2	-	28	3676	c.3457G>A	c.(3457-3459)GAG>AAG	p.E1153K	DIAPH3_uc001vhs.2_RNA	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	1153					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TCCTTCTTCTCAGCTGCCTTG	0.413													0	0	0	0.002222	0	37	89										T	60240843	C	T	60240843	3	4	97	1	0	0	0	0	1	0	0	0	4520	835	29	1	128	1	DIAPH3	13	60240843	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	20977704	60240843	54929035	332	29820										
SLITRK6	84189	broad.mit.edu	37	chr13	86370509	86370509	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccttttgcttcacaatttatTagcattgtgccatctttttc	4	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr13:86370509T>G	uc001vll.1	-	2	594	c.135A>C	c.(133-135)CTA>CTC	p.L45L	SLITRK6_uc010afe.1_5'Flank	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	45	LRRNT 1.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CACAATTTATTAGCATTGTGC	0.408													0	0	0	0.002836	0	34	48										G	86370509	T	G	86370509	2	3	97	1	0	0	0	0	0	0	0	1	14747	1741	61	5		5	SLITRK6	13	86370509	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	26129666	86370509	28799369	333	29821										
NALCN	259232	broad.mit.edu	37	chr13	101759884	101759884	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccggcaaaagtttctgaaccTgtgttctcgcccgacaatga	9	12	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr13:101759884T>A	uc001vox.1	-	22	2722	c.2533A>T	c.(2533-2535)AGG>TGG	p.R845W		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	845	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTTCTGAACCTGTGTTCTCGC	0.502													0	0	0	0.005443	0	27	55										A	101759884	T	A	101759884	3	1	97	1	0	0	0	0	1	0	0	0	10148	1579	55	5	2775	5	NALCN	13	101759884	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	15389375	101759884	13409994	334	29822										
FAM155A	728215	broad.mit.edu	37	chr13	108518492	108518492	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agaaaaagagccttgccccgGtcgtctttgcctcggttgcc	11	13	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr13:108518492G>A	uc001vql.2	-	1	969	c.453C>T	c.(451-453)GAC>GAT	p.D151D		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	151						integral to membrane	binding			skin(1)	1						CCTTGCCCCGGTCGTCTTTGC	0.692													0	0	0	0.004007	0	16	26										A	108518492	G	A	108518492	2	1	97	1	0	0	0	0	0	0	0	1	5465	1252	44	2		2	FAM155A	13	108518492	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	6758608	108518492	6651386	335	29823										
OR4N2	390429	broad.mit.edu	37	chr14	20296468	20296468	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgttgaatcctgtcatttaTacccttcgcaaccaggaagt	7	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:20296468T>A	uc010tkv.1	+	1	861	c.861T>A	c.(859-861)TAT>TAA	p.Y287*		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGTCATTTATACCCTTCGCA	0.418													0	0	0	0.008871	0	21	70										A	20296468	T	A	20296468	4	1	97	1	0	0	0	0	0	1	0	0	11077	1413	49	5	863	5	OR4N2	14	20296468	Nonsense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08		20296468	87053072	336	29824										
OR4K17	390436	broad.mit.edu	37	chr14	20586496	20586496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgttttataccatcatcactCctatcttgaatccaattatc	2	11	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:20586496C>T	uc001vwo.1	+	1	931	c.931C>T	c.(931-933)CCT>TCT	p.P311S		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CATCATCACTCCTATCTTGAA	0.373													0	0	0	0.001855	0	12	38										T	20586496	C	T	20586496	3	4	97	1	0	0	0	0	1	0	0	0	11071	855	30	1	933	1	OR4K17	14	20586496	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	290028	20586496	86763044	337	29825										
TEP1	7011	broad.mit.edu	37	chr14	20848088	20848088	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcccctccttgattgtcataCctgccaagttctcaggtcca	7	15	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:20848088C>A	uc001vxe.2	-	35	5167	c.5127_splice	c.e35+1	p.Q1709_splice	TEP1_uc010ahk.2_Splice_Site_p.Q1052_splice|TEP1_uc010tlf.1_Splice_Site|TEP1_uc010tlg.1_Splice_Site_p.Q1601_splice|TEP1_uc010tlh.1_Splice_Site_p.Q47_splice	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GATTGTCATACCTGCCAAGTT	0.507													1	0	0.00400662	0.004007	0.00485406	16	56										A	20848088	C	A	20848088	5	1	97	1	0	0	0	0	0	0	1	0	15756	521	18	4	2839	4	TEP1	14	20848088	Splice_Site	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	261592	20848088	86501452	338	29826										
AP1G2	8906	broad.mit.edu	37	chr14	24034889	24034889	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgtcaccagagtccggaggaTgtgtaccagctggggtacca	14	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:24034889T>C	uc001wkl.2	-	7	1004	c.667A>G	c.(667-669)ATC>GTC	p.I223V	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_Missense_Mutation_p.I151V|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_RNA|AP1G2_uc001wkp.1_5'Flank|AP1G2_uc010tnp.1_Missense_Mutation_p.I223V|AP1G2_uc010aks.2_Missense_Mutation_p.I151V|AP1G2_uc010akt.2_Missense_Mutation_p.I151V|AP1G2_uc010tnq.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	223					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		GTCCGGAGGATGTGTACCAGC	0.557													0	0	0	0.00245	0	13	52										C	24034889	T	C	24034889	3	2	97	1	0	0	0	0	1	0	0	0	733	1464	51	5	1754	5	AP1G2	14	24034889	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	3186801	24034889	83314651	339	29827										
ZFP36L1	677	broad.mit.edu	37	chr14	69256333	69256333	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggagtctgagccactgtggcTgctgctggagctgctcaggt	16	10	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:69256333T>G	uc001xkh.1	-	2	1064	c.934A>C	c.(934-936)AGC>CGC	p.S312R	ZFP36L1_uc001xki.1_Missense_Mutation_p.S312R	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	312	Poly-Ser.				regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCACTGTGGCTGCTGCTGGAG	0.597											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	47	172										G	69256333	T	G	69256333	3	3	97	1	0	0	0	0	1	0	0	0	17643	1580	55	5	86	5	ZFP36L1	14	69256333	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	45221444	69256333	38093207	340	29828										
DCAF5	8816	broad.mit.edu	37	chr14	69521082	69521082	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgagcttcttggtttcaaaaGggtgctctacagagccgcta	11	9	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:69521082G>T	uc001xkp.2	-	9	2540	c.2321C>A	c.(2320-2322)CCT>CAT	p.P774H	DCAF5_uc001xkq.2_Missense_Mutation_p.P773H	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	774						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						GGTTTCAAAAGGGTGCTCTAC	0.597													1	0	2.47511e-08	0.008361	3.08497e-08	27	108										T	69521082	G	T	69521082	3	4	97	1	0	0	0	0	1	0	0	0	4273	1000	35	4	511	4	DCAF5	14	69521082	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	264749	69521082	37828458	341	29829										
SLC8A3	6547	broad.mit.edu	37	chr14	70512799	70512799	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcccctcccaggtgcggccgCcttcggtacaagagcacgct	11	17	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:70512799C>T	uc001xly.2	-	8	3403	c.2649G>A	c.(2647-2649)AGG>AGA	p.R883R	SLC8A3_uc001xlu.2_Silent_p.R240R|SLC8A3_uc001xlv.2_Silent_p.R254R|SLC8A3_uc001xlw.2_Silent_p.R880R|SLC8A3_uc001xlx.2_Silent_p.R881R|SLC8A3_uc001xlz.2_Silent_p.R877R|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_3'UTR	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	883	Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GGTGCGGCCGCCTTCGGTACA	0.602											OREG0022773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	9	35										T	70512799	C	T	70512799	2	4	97	1	0	0	0	0	0	0	0	1	14708	738	26	2		2	SLC8A3	14	70512799	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	991717	70512799	36836741	342	29830										
PSEN1	5663	broad.mit.edu	37	chr14	73659343	73659369	+	Splice_Site	DEL	TTTTTTCAGGGAAGTGTTTAAAACCTA	TTTTTTCAGGGAAGTGTTTAAAACCTA	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cttttaaaatctgtgtaattTtttttcagggaagtgtttaa					rs63750311		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:73659343_73659369delTTTTTTCAGGGAAGTGTTTAAAACCTA	uc001xnr.2	+	7	833	c.549_splice	c.e7-1	p.G183_splice	PSEN1_uc001xnv.2_Splice_Site_p.G179_splice|PSEN1_uc010ark.2_Splice_Site_p.G179_splice|PSEN1_uc001xnt.1_Splice_Site|PSEN1_uc001xnu.2_Splice_Site	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467						amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		CTGTGTAATTTTTTTTCAGGGAAGTGTTTAAAACCTATAACGTTGCT	0.308																		14	100	---	---								-	73659369	TTTTTTCAGGGAAGTGTTTAAAACCTA	-	73659343	8	5	97	1	0	1	0	1	0	0	1	0	12650	1856	64	0		0	PSEN1	14	73659343	Splice_Site	DEL	TTTTTTCAGGGAAGTGTTTAAAACCTA	TCGA-G2-A2ES-01A-11D-A17V-08	3146544	73659343	33690197	343	29831										
ENTPD5	957	broad.mit.edu	37	chr14	74438590	74438590	+	Frame_Shift_Del	DEL	A	A	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tttcaaaatcttcaacttttAaaataccccccttttcataa							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:74438590delA	uc010tuo.1	-	14	1360	c.1049delT	c.(1048-1050)TTAfs	p.L350fs	ENTPD5_uc001xpi.2_Frame_Shift_Del_p.L350fs	NM_001249	NP_001240	O75356	ENTP5_HUMAN	ectonucleoside triphosphate diphosphohydrolase 5	350					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00394)		TTCAACTTTTAAAATACCCCC	0.378																		64	215	---	---								-	74438590	A	-	74438590	7	5	97	1	0	1	0	1	0	0	0	0	5142	372	13	0	249	0	ENTPD5	14	74438590	Frame_Shift_Del	DEL	A	TCGA-G2-A2ES-01A-11D-A17V-08	779247	74438590	32910950	344	29832										
BATF	10538	broad.mit.edu	37	chr14	75989032	75989032	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggaagatttcagccatgcctCacagctccgacagcagtgac	10	13	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:75989032C>T	uc001xrr.2	+	1	249	c.7C>T	c.(7-9)CAC>TAC	p.H3Y		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	3						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)		AGCCATGCCTCACAGCTCCGA	0.592													0	0	0	0.002299	0	23	63										T	75989032	C	T	75989032	3	4	97	1	0	0	0	0	1	0	0	0	1325	826	29	1	9	1	BATF	14	75989032	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1550442	75989032	31360508	345	29833										
GALC	2581	broad.mit.edu	37	chr14	88459416	88459416	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gccagcagcgcacacagcagCaagggcaccgcggcgcggcc	15	17	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:88459416C>T	uc001xvt.2	-	1	492	c.93G>A	c.(91-93)TTG>TTA	p.L31L	GALC_uc010tvx.1_Intron|GALC_uc010tvy.1_Silent_p.L31L|GALC_uc010tvz.1_5'Flank|GALC_uc001xvu.1_Silent_p.L31L	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	31					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						CACACAGCAGCAAGGGCACCG	0.731													0	0	0	0.000602	0	4	9										T	88459416	C	T	88459416	2	4	97	1	0	0	0	0	0	0	0	1	6201	709	25	2		2	GALC	14	88459416	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	12470384	88459416	18890124	346	29834										
CCDC88C	440193	broad.mit.edu	37	chr14	91792370	91792370	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctccagcatggccttggtttCaattaaaatgatattatctt	6	8	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:91792370C>T	uc010aty.2	-	11	1180	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	361	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GCCTTGGTTTCAATTAAAATG	0.458													0	0	0	0.004482	0	8	23										T	91792370	C	T	91792370	3	4	97	1	0	0	0	0	1	0	0	0	2865	835	29	1	5085	1	CCDC88C	14	91792370	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3332954	91792370	15557170	347	29835										
ITPK1	3705	broad.mit.edu	37	chr14	93412799	93412799	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggagagctcccggatgacctCgtcgctcggccgctcgaaca	13	15	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:93412799C>T	uc001ybg.2	-	10	1067	c.778G>A	c.(778-780)GAG>AAG	p.E260K	ITPK1_uc001ybe.2_Missense_Mutation_p.E260K|ITPK1_uc001ybf.2_Missense_Mutation_p.E141K|ITPK1_uc001ybh.2_Missense_Mutation_p.E260K	NM_014216	NP_055031	Q13572	ITPK1_HUMAN	inositol 1,3,4-triphosphate 5/6 kinase isoform	260	ATP-grasp.				blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding				0		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		CGGATGACCTCGTCGCTCGGC	0.632													0	0	0	0.001882	0	20	67										T	93412799	C	T	93412799	3	4	97	1	0	0	0	0	1	0	0	0	7916	893	31	1	522	1	ITPK1	14	93412799	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1620429	93412799	13936741	348	29836										
DDX24	57062	broad.mit.edu	37	chr14	94526714	94526714	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgtgaggtcaatgaccttgGgcttgcccctcatgccaatt	10	11	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:94526714G>C	uc001ycj.2	-	5	1742	c.1643C>G	c.(1642-1644)CCC>CGC	p.P548R	DDX24_uc010twq.1_Missense_Mutation_p.P505R|DDX24_uc010twr.1_Missense_Mutation_p.P298R	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	548					RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		AATGACCTTGGGCTTGCCCCT	0.468													0	0	0	0.00361	0	52	138										C	94526714	G	C	94526714	3	2	97	1	0	0	0	0	1	0	0	0	4351	1232	43	4	956	4	DDX24	14	94526714	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1113915	94526714	12822826	349	29837										
PPP4R4	57718	broad.mit.edu	37	chr14	94674875	94674875	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcgacagaatcccactgagaCgcttcggagagtgttgccaa	12	11	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:94674875C>T	uc001ycs.1	+	3	420	c.266C>T	c.(265-267)ACG>ATG	p.T89M	PPP4R4_uc001ycr.2_Missense_Mutation_p.T89M	NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	89						cytoplasm|protein serine/threonine phosphatase complex	protein binding	p.T89M(1)		skin(3)|upper_aerodigestive_tract(1)	4						CCCACTGAGACGCTTCGGAGA	0.388													0	0	0	0.00499	0	16	46										T	94674875	C	T	94674875	3	4	97	1	0	0	0	0	1	0	0	0	12405	536	19	2	276	2	PPP4R4	14	94674875	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	148161	94674875	12674665	350	29838										
DYNC1H1	1778	broad.mit.edu	37	chr14	102452341	102452341	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggtttaatgcactgtttgtCaggcctcacatccgtggggc	12	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:102452341C>T	uc001yks.2	+	8	1943	c.1779C>T	c.(1777-1779)GTC>GTT	p.V593V		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	593	Interaction with DYNC1I2 (By similarity).|Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CACTGTTTGTCAGGCCTCACA	0.527													0	0	0	0.008361	0	30	55										T	102452341	C	T	102452341	2	4	97	1	0	0	0	0	0	0	0	1	4841	813	29	1		1	DYNC1H1	14	102452341	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	7777466	102452341	4897199	351	29839										
DYNC1H1	1778	broad.mit.edu	37	chr14	102493553	102493553	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cacttgcttctgattggtgtTagtggagcaggaaaaactac	11	7	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:102493553T>C	uc001yks.2	+	45	8978	c.8814T>C	c.(8812-8814)GTT>GTC	p.V2938V		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2938	AAA 4 (By similarity).|ATP (Potential).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGATTGGTGTTAGTGGAGCAG	0.463													0	0	0	0.00361	0	116	313										C	102493553	T	C	102493553	2	2	97	1	0	0	0	0	0	0	0	1	4841	1741	61	5		5	DYNC1H1	14	102493553	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	41212	102493553	4855987	352	29840										
AHNAK2	113146	broad.mit.edu	37	chr14	105419725	105419725	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccatggacttgcctggggctGacgccccgaacaatggcatc	12	14	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr14:105419725G>A	uc010axc.1	-	7	2183	c.2063C>T	c.(2062-2064)TCA>TTA	p.S688L	AHNAK2_uc001ypx.2_Missense_Mutation_p.S588L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	688						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCTGGGGCTGACGCCCCGAA	0.542													0	0	0	0.00361	0	78	232										A	105419725	G	A	105419725	3	1	97	1	0	0	0	0	1	0	0	0	415	1294	45	1	15328	1	AHNAK2	14	105419725	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2926172	105419725	1929815	353	29841										
NDN	4692	broad.mit.edu	37	chr15	23931699	23931699	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccgaaggtggagtgcttcttCcagggccgcagccccaggat	14	13	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:23931699C>T	uc001ywk.2	-	1	752	c.666G>A	c.(664-666)TGG>TGA	p.W222*		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	222	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		AGTGCTTCTTCCAGGGCCGCA	0.622									Prader-Willi_syndrome				0	0	0	0.004007	0	17	45										T	23931699	C	T	23931699	4	4	97	1	0	0	0	0	0	1	0	0	10247	856	30	1	303	1	NDN	15	23931699	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08		23931699	78599693	354	29842										
GABRG3	2567	broad.mit.edu	37	chr15	27765177	27765177	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaagaatgggatacttcaccAttcagacatacattccctgt	7	10	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:27765177A>T	uc001zbg.1	+	7	938	c.772A>T	c.(772-774)ATT>TTT	p.I258F		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	258	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ATACTTCACCATTCAGACATA	0.353													0	0	0	0.001168	0	6	9										T	27765177	A	T	27765177	3	4	97	1	0	0	0	0	1	0	0	0	6173	217	8	5	798	5	GABRG3	15	27765177	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	3833478	27765177	74766215	355	29843										
MTMR10	54893	broad.mit.edu	37	chr15	31239408	31239408	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagatccgggtgctgtcataCaacactgccaggtaggtttc	12	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:31239408C>T	uc001zfh.1	-	14	1571	c.1473G>A	c.(1471-1473)TTG>TTA	p.L491L	MTMR10_uc010ubk.1_5'UTR|MTMR10_uc001zfg.1_Silent_p.L72L|MTMR10_uc010azx.1_Silent_p.L243L|MTMR10_uc001zfi.1_Silent_p.L243L|MTMR10_uc001zfj.2_Silent_p.L409L|MTMR10_uc001zfk.2_Silent_p.L243L	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	491	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		TGCTGTCATACAACACTGCCA	0.507													0	0	0	0.007835	0	38	115										T	31239408	C	T	31239408	2	4	97	1	0	0	0	0	0	0	0	1	9939	477	17	2		2	MTMR10	15	31239408	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3474231	31239408	71291984	356	29844										
AQR	9716	broad.mit.edu	37	chr15	35212624	35212624	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggtatgatgccacctggtggAgtgtgtttgaactgcagaat	14	6	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:35212624A>C	uc001ziv.2	-	14	1311	c.1130T>G	c.(1129-1131)CTC>CGC	p.L377R		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	377						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		CACCTGGTGGAGTGTGTTTGA	0.318													0	0	0	0.000978	0	9	28										C	35212624	A	C	35212624	3	2	97	1	0	0	0	0	1	0	0	0	835	304	11	5	3415	5	AQR	15	35212624	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	3973216	35212624	67318768	357	29845										
C15orf52	388115	broad.mit.edu	37	chr15	40627555	40627555	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagggcaagtctgtacttccAgctcagcctggtgattgctc	11	12	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:40627555A>G	uc001zlh.3	-	11	1425	c.1409T>C	c.(1408-1410)CTG>CCG	p.L470P	C15orf52_uc010ucn.1_Missense_Mutation_p.L260P	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	470										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTGTACTTCCAGCTCAGCCTG	0.662													0	0	0	0.004289	0	32	67										G	40627555	A	G	40627555	3	3	97	1	0	0	0	0	1	0	0	0	1800	188	7	5	199	5	C15orf52	15	40627555	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	5414931	40627555	61903837	358	29846										
FAM82A2	55177	broad.mit.edu	37	chr15	41037420	41037420	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcactttctttgtcagagtCccgctcattgtcagactccg	7	14	5	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:41037420C>T	uc001zmo.1	-	5	706	c.562G>A	c.(562-564)GAC>AAC	p.D188N	FAM82A2_uc001zmp.1_Missense_Mutation_p.D188N|FAM82A2_uc001zmq.1_Missense_Mutation_p.D188N	NM_018145	NP_060615	Q96TC7	RMD3_HUMAN	family with sequence similarity 82, member A2	188					apoptosis|cell differentiation	integral to membrane|microtubule|mitochondrial membrane|nucleus|spindle pole	protein binding				0						TTGTCAGAGTCCCGCTCATTG	0.498													0	0	0	0.00361	0	85	106										T	41037420	C	T	41037420	3	4	97	1	0	0	0	0	1	0	0	0	5631	855	30	1	886	1	FAM82A2	15	41037420	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	409865	41037420	61493972	359	29847										
INO80	54617	broad.mit.edu	37	chr15	41280022	41280022	+	Missense_Mutation	SNP	T	T	G													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcttgtgcttacctcactctTctccttggctctttgcagaa							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:41280022T>G	uc001zni.2	-	30	3934	c.3721A>C	c.(3721-3723)AAG>CAG	p.K1241Q	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1241	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.|Helicase C-terminal.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						ACCTCACTCTTCTCCTTGGCT	0.468													0	0	0	0.00361	0	105	346										G	41280022	T	G	41280022	3	3	97	1	0	0	0	0	1	0	0	0	7746	1792	62	5	977	5	INO80	15	41280022	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	242602	41280022	61251370	360	29848	152	2								
INO80	54617	broad.mit.edu	37	chr15	41280032	41280032	+	Silent	SNP	T	T	C													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acctcactcttctccttggcTctttgcagaatgcgttcttc							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:41280032T>C	uc001zni.2	-	30	3924	c.3711A>G	c.(3709-3711)AGA>AGG	p.R1237R	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1237	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.|Helicase C-terminal.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TCTCCTTGGCTCTTTGCAGAA	0.478													0	0	0	0.00361	0	103	330										C	41280032	T	C	41280032	2	2	97	1	0	0	0	0	0	0	0	1	7746	1548	54	5		5	INO80	15	41280032	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	10	41280032	61251360	361	29849	152	2								
SPTBN5	51332	broad.mit.edu	37	chr15	42168429	42168429	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagggctcatgcgcagccatCagccccttctcttccatcca	8	17	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:42168429C>T	uc001zos.2	-	21	4233	c.3900G>A	c.(3898-3900)CTG>CTA	p.L1300L		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1335	Spectrin 10.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCGCAGCCATCAGCCCCTTCT	0.627													0	0	0	0.000978	0	11	25										T	42168429	C	T	42168429	2	4	97	1	0	0	0	0	0	0	0	1	15121	813	29	1		1	SPTBN5	15	42168429	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	888397	42168429	60362963	362	29850										
SPTBN5	51332	broad.mit.edu	37	chr15	42170747	42170747	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cccgttgggccacttgttccTgtacttgcttcagcagcccc	9	16	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:42170747T>A	uc001zos.2	-	17	3491	c.3158A>T	c.(3157-3159)CAG>CTG	p.Q1053L		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1088					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CACTTGTTCCTGTACTTGCTT	0.642													0	0	0	0.008291	0	10	33										A	42170747	T	A	42170747	3	1	97	1	0	0	0	0	1	0	0	0	15121	1580	55	5	7969	5	SPTBN5	15	42170747	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	2318	42170747	60360645	363	29851										
TGM5	9333	broad.mit.edu	37	chr15	43531079	43531079	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctctggatgctctttgtgctGataaaattgccaacagaact	8	9	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:43531079G>A	uc001zrd.1	-	9	1289	c.1281C>T	c.(1279-1281)ATC>ATT	p.I427I	TGM5_uc001zrc.1_Silent_p.I84I|TGM5_uc001zre.1_Silent_p.I345I	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	427					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TCTTTGTGCTGATAAAATTGC	0.507													0	0	0	0.00499	0	17	33										A	43531079	G	A	43531079	2	1	97	1	0	0	0	0	0	0	0	1	15830	1280	45	1		1	TGM5	15	43531079	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1360332	43531079	59000313	364	29852										
SLC12A1	6557	broad.mit.edu	37	chr15	48559784	48559784	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgcaaactgtgtgttaaggaGatgaacagtggcatggcgaa	14	6	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:48559784G>T	uc001zwn.3	+	18	2397	c.2181G>T	c.(2179-2181)GAG>GAT	p.E727D	SLC12A1_uc010uew.1_Missense_Mutation_p.E533D|SLC12A1_uc010bem.2_Missense_Mutation_p.E727D|SLC12A1_uc001zwq.3_Missense_Mutation_p.E498D|SLC12A1_uc001zwr.3_Missense_Mutation_p.E454D	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	727					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GTGTTAAGGAGATGAACAGTG	0.433													1	0	6.12954e-19	0.004656	8.07937e-19	26	64										T	48559784	G	T	48559784	3	4	97	1	0	0	0	0	1	0	0	0	14382	933	33	3	2347	3	SLC12A1	15	48559784	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5028705	48559784	53971608	365	29853										
APH1B	83464	broad.mit.edu	37	chr15	63579740	63579740	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttctcctcaattcttcctttAttcaggtatgtgtctcatag	5	10	5	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:63579740A>G	uc002ama.2	+	4	547	c.473A>G	c.(472-474)TAT>TGT	p.Y158C	APH1B_uc002amb.2_Intron|APH1B_uc010bgq.2_Missense_Mutation_p.Y104C|APH1B_uc010bgr.2_Missense_Mutation_p.Y104C	NM_031301	NP_112591	Q8WW43	APH1B_HUMAN	presenilin stabilization factor-like isoform 1	158	Helical; Name=5; (Potential).				apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	integral to membrane|plasma membrane|transport vesicle	peptidase activity|protein binding				0						TTCTTCCTTTATTCAGGTATG	0.423													0	0	0	0.00361	0	85	188										G	63579740	A	G	63579740	3	3	97	1	0	0	0	0	1	0	0	0	772	449	16	5	487	5	APH1B	15	63579740	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	15019956	63579740	38951652	366	29854										
CSNK1G1	53944	broad.mit.edu	37	chr15	64592686	64592686	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctttcatccttttccctacTaggatggtccatgatcctac	5	13	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:64592686T>C	uc002anf.2	-	2	493	c.13A>G	c.(13-15)AGT>GGT	p.S5G	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Missense_Mutation_p.S5G|CSNK1G1_uc002anh.1_Missense_Mutation_p.S5G|CSNK1G1_uc002anj.2_5'UTR|CSNK1G1_uc010uip.1_RNA	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	5					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						TTTTCCCTACTAGGATGGTCC	0.448													0	0	0	0.00361	0	51	148										C	64592686	T	C	64592686	3	2	97	1	0	0	0	0	1	0	0	0	3954	1522	53	5	1299	5	CSNK1G1	15	64592686	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1012946	64592686	37938706	367	29855										
THAP10	56906	broad.mit.edu	37	chr15	71174825	71174843	+	Frame_Shift_Del	DEL	TATAAGACAAATCACTCTG	TATAAGACAAATCACTCTG	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttctttcacctgtacagccaTataagacaaatcactctgtt							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:71174825_71174843delTATAAGACAAATCACTCTG	uc002asv.2	-	3	866_884	c.724_742delCAGAGTGATTTGTCTTATA	c.(724-744)CAGAGTGATTTGTCTTATATGfs	p.Q242fs	LRRC49_uc002asu.2_Intron	NM_020147	NP_064532	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	242_248							DNA binding|metal ion binding			ovary(1)|skin(1)	2						TGTACAGCCATATAAGACAAATCACTCTGTTCACTCTTG	0.356																		7	190	---	---								-	71174843	TATAAGACAAATCACTCTG	-	71174825	7	5	97	1	0	1	0	1	0	0	0	0	15839	1406	49	0	35	0	THAP10	15	71174825	Frame_Shift_Del	DEL	TATAAGACAAATCACTCTG	TCGA-G2-A2ES-01A-11D-A17V-08	6582139	71174825	31356567	368	29856										
HCN4	10021	broad.mit.edu	37	chr15	73616530	73616530	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgtccacgctcagcgagtaGaggcggcagtaggtgtcggc	16	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:73616530G>T	uc002avp.2	-	7	3037	c.2043C>A	c.(2041-2043)CTC>CTA	p.L681L		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	681	Cytoplasmic (Potential).|cAMP.				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		TCAGCGAGTAGAGGCGGCAGT	0.642													1	0	1.77063e-15	0.005443	2.29123e-15	27	65										T	73616530	G	T	73616530	2	4	97	1	0	0	0	0	0	0	0	1	6999	929	33	3		3	HCN4	15	73616530	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2441705	73616530	28914862	369	29857										
FBXO22	26263	broad.mit.edu	37	chr15	76222340	76222340	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actttcagtgatatgaatatCatcttggctggaggccaggt	11	7	3	2	rs143480986		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:76222340C>T	uc002bbk.2	+	6	849	c.744C>T	c.(742-744)ATC>ATT	p.I248I	FBXO22_uc002bbj.1_Silent_p.I248I|FBXO22_uc002bbl.2_Silent_p.I144I	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	248					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						ATATGAATATCATCTTGGCTG	0.438													0	0	0	0.002836	0	34	97										T	76222340	C	T	76222340	2	4	97	1	0	0	0	0	0	0	0	1	5734	816	29	1		1	FBXO22	15	76222340	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2605810	76222340	26309052	370	29858										
IREB2	3658	broad.mit.edu	37	chr15	78758655	78758655	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cctggaggtggtgacctgcaGaaagcaggaaagctctctcc	13	11	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:78758655G>A	uc002bdr.2	+	5	615	c.453G>A	c.(451-453)CAG>CAA	p.Q151Q	IREB2_uc010unb.1_5'UTR|IREB2_uc002bdq.2_Silent_p.Q151Q	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	151							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		GTGACCTGCAGAAAGCAGGAA	0.458													0	0	0	0.001523	0	21	35										A	78758655	G	A	78758655	2	1	97	1	0	0	0	0	0	0	0	1	7826	933	33	1		1	IREB2	15	78758655	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2536315	78758655	23772737	371	29859										
ADAMTS7	11173	broad.mit.edu	37	chr15	79090340	79090340	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aatcaccccgctgtgccagcCtctccggggcctgacgcttg	11	17	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:79090340C>G	uc002bej.3	-	3	783	c.572G>C	c.(571-573)AGG>ACG	p.R191T	ADAMTS7_uc010und.1_Missense_Mutation_p.R191T|ADAMTS7_uc002bek.1_Missense_Mutation_p.R191T	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	191					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CTGTGCCAGCCTCTCCGGGGC	0.647													0	0	0	0.001786	0	29	108										G	79090340	C	G	79090340	3	3	97	1	0	0	0	0	1	0	0	0	271	681	24	4	4576	4	ADAMTS7	15	79090340	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	331685	79090340	23441052	372	29860										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84651522	84651522	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgacctttatctggatgatGaccacattagtaaccagcct	7	10	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:84651522G>A	uc002bjz.3	+	21	3366	c.3142G>A	c.(3142-3144)GAC>AAC	p.D1048N	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.D1048N|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.D1048N	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1048						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTGGATGATGACCACATTAG	0.448													0	0	0	0.003954	0	23	77										A	84651522	G	A	84651522	3	1	97	1	0	0	0	0	1	0	0	0	276	1290	45	1	3220	1	ADAMTSL3	15	84651522	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	5561182	84651522	17879870	373	29861										
ALPK3	57538	broad.mit.edu	37	chr15	85401501	85401501	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggtcagagcagcaggagacGgggaggcaaccacacctgaa	15	10	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:85401501G>A	uc002ble.2	+	6	4305	c.4138G>A	c.(4138-4140)GGG>AGG	p.G1380R		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1380					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCAGGAGACGGGGAGGCAAC	0.652													0	0	0	0.000248	0	4	11										A	85401501	G	A	85401501	3	1	97	1	0	0	0	0	1	0	0	0	546	1116	39	2	4160	2	ALPK3	15	85401501	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	749979	85401501	17129891	374	29862										
AKAP13	11214	broad.mit.edu	37	chr15	86123759	86123759	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcaactcctgaactacatacAgctacagattatagagatgg	8	9	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:86123759A>T	uc002blv.1	+	7	2630	c.2460A>T	c.(2458-2460)ACA>ACT	p.T820T	AKAP13_uc002blt.1_Silent_p.T820T|AKAP13_uc002blu.1_Silent_p.T820T|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	820					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AACTACATACAGCTACAGATT	0.498													0	0	0	0.00361	0	76	184										T	86123759	A	T	86123759	2	4	97	1	0	0	0	0	0	0	0	1	449	175	7	5		5	AKAP13	15	86123759	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	722258	86123759	16407633	375	29863										
WDR93	56964	broad.mit.edu	37	chr15	90245001	90245001	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcattcccaagaggaagtcaGacccagaaaataaagcaccc	7	12	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:90245001G>C	uc002boj.2	+	2	125	c.24G>C	c.(22-24)CAG>CAC	p.Q8H	WDR93_uc002bok.3_Missense_Mutation_p.Q8H|WDR93_uc010bnr.2_Missense_Mutation_p.Q8H	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	8					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			GAGGAAGTCAGACCCAGAAAA	0.463													0	0	0	0.00361	0	47	136										C	90245001	G	C	90245001	3	2	97	1	0	0	0	0	1	0	0	0	17337	933	33	1	26	1	WDR93	15	90245001	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4121242	90245001	12286391	376	29864										
CRTC3	64784	broad.mit.edu	37	chr15	91172733	91172733	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcagacagctgtcttcaaCcagcccactggccccatatc	7	17	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:91172733C>A	uc002bpp.2	+	11	1341	c.1235C>A	c.(1234-1236)ACC>AAC	p.T412N	CRTC3_uc002bpo.2_Missense_Mutation_p.T412N	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	412					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CTGTCTTCAACCAGCCCACTG	0.567			T	MAML2	salivary gland mucoepidermoid								1	0	9.42957e-07	0.007835	1.16228e-06	44	116										A	91172733	C	A	91172733	3	1	97	1	0	0	0	0	1	0	0	0	3901	507	18	4	1277	4	CRTC3	15	91172733	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	927732	91172733	11358659	377	29865										
IGF1R	3480	broad.mit.edu	37	chr15	99459919	99459919	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agacaaaatccccatcaggaAgtatgccgacggcaccatcg	9	13	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:99459919A>C	uc002bul.2	+	10	2065	c.2015A>C	c.(2014-2016)AAG>ACG	p.K672T	IGF1R_uc010urq.1_Missense_Mutation_p.K672T|IGF1R_uc010bon.2_Missense_Mutation_p.K672T|IGF1R_uc010urr.1_Missense_Mutation_p.K122T	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	672	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CCCATCAGGAAGTATGCCGAC	0.488													0	0	0	0.001523	0	19	47										C	99459919	A	C	99459919	3	2	97	1	0	0	0	0	1	0	0	0	7571	72	3	5	2053	5	IGF1R	15	99459919	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	8287186	99459919	3071473	378	29866										
ADAMTS17	170691	broad.mit.edu	37	chr15	100821443	100821443	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccggactcaccatgttcatGacggtcaggatgaacctctg	10	12	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:100821443G>A	uc002bvv.1	-	4	859	c.780C>T	c.(778-780)GTC>GTT	p.V260V	ADAMTS17_uc002bvx.1_Silent_p.V17V	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	260	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CCATGTTCATGACGGTCAGGA	0.622													0	0	0	0.002096	0	31	119										A	100821443	G	A	100821443	2	1	97	1	0	0	0	0	0	0	0	1	262	1277	45	1		1	ADAMTS17	15	100821443	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1361524	100821443	1709949	379	29867										
PCSK6	5046	broad.mit.edu	37	chr15	101906500	101906500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcagtggacagtcatgaattCccagtttgtaaacccttcat	8	10	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr15:101906500C>T	uc002bwy.2	-	14	2073	c.1759G>A	c.(1759-1761)GAA>AAA	p.E587K	PCSK6_uc010bpd.2_Missense_Mutation_p.E383K|PCSK6_uc010bpe.2_Missense_Mutation_p.E587K|PCSK6_uc002bxa.2_Missense_Mutation_p.E587K|PCSK6_uc002bxb.2_Missense_Mutation_p.E587K|PCSK6_uc002bxc.1_Missense_Mutation_p.E587K|PCSK6_uc002bxd.1_Missense_Mutation_p.E587K|PCSK6_uc002bxe.2_Missense_Mutation_p.E587K|PCSK6_uc002bxf.1_Missense_Mutation_p.E87K	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	587	Homo B/P.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTCATGAATTCCCAGTTTGTA	0.542													0	0	0	0.001984	0	7	61										T	101906500	C	T	101906500	3	4	97	1	0	0	0	0	1	0	0	0	11604	864	30	1	1619	1	PCSK6	15	101906500	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1085057	101906500	624892	380	29868										
CCDC78	124093	broad.mit.edu	37	chr16	775278	775278	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcattctcggggttcatggTgttcttgggctgcacctgaa	12	10	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:775278T>C	uc002cjg.2	-	5	557	c.451A>G	c.(451-453)ACC>GCC	p.T151A	CCDC78_uc002cjf.2_5'UTR|CCDC78_uc002cji.3_Missense_Mutation_p.T225A|CCDC78_uc002cjj.3_Missense_Mutation_p.T95A|CCDC78_uc002cjh.2_5'UTR|CCDC78_uc010uuo.1_Missense_Mutation_p.T151A|CCDC78_uc002cjk.2_Missense_Mutation_p.T140A|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	151										central_nervous_system(1)	1		Hepatocellular(780;0.0218)				GGGTTCATGGTGTTCTTGGGC	0.632													0	0	0	0.00361	0	61	90										C	775278	T	C	775278	3	2	97	1	0	0	0	0	1	0	0	0	2852	1696	59	5	905	5	CCDC78	16	775278	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08		775278	89579475	381	29869										
RPUSD1	113000	broad.mit.edu	37	chr16	836923	836923	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaggcttggctttgggttctCacaacctggggcgcagaagg	16	9	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:836923C>T	uc002cka.2	-	4	649	c.415G>A	c.(415-417)GAG>AAG	p.E139K	RPUSD1_uc002ckb.2_Missense_Mutation_p.E139K|RPUSD1_uc002ckc.2_Missense_Mutation_p.E10K|RPUSD1_uc002ckd.2_Silent_p.V104V|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing	139					pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				TTTGGGTTCTCACAACCTGGG	0.647													0	0	0	0.002299	0	21	85										T	836923	C	T	836923	3	4	97	1	0	0	0	0	1	0	0	0	13666	835	29	1	531	1	RPUSD1	16	836923	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	61645	836923	89517830	382	29870										
BAIAP3	8938	broad.mit.edu	37	chr16	1395092	1395092	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcgcttctgggatagcatCcctggccggtgggtgccccg	15	14	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:1395092C>G	uc002clk.1	+	21	2037	c.2037C>G	c.(2035-2037)ATC>ATG	p.I679M	BAIAP3_uc002clj.2_Missense_Mutation_p.I661M|BAIAP3_uc010uuz.1_Missense_Mutation_p.I644M|BAIAP3_uc010uva.1_Missense_Mutation_p.I616M|BAIAP3_uc010uvc.1_Missense_Mutation_p.I608M	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	679	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				GGGATAGCATCCCTGGCCGGT	0.647													0	0	0	0.006999	0	41	111										G	1395092	C	G	1395092	3	3	97	1	0	0	0	0	1	0	0	0	1304	845	30	1	2119	1	BAIAP3	16	1395092	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	558169	1395092	88959661	383	29871										
SRRM2	23524	broad.mit.edu	37	chr16	2808993	2808993	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aatccatctttagcaggtcaGagagcagctctcctcgacgg	10	12	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:2808993G>A	uc002crk.2	+	6	1150	c.601G>A	c.(601-603)GAG>AAG	p.E201K	SRRM2_uc002crj.1_Missense_Mutation_p.E105K|SRRM2_uc002crl.1_Missense_Mutation_p.E201K|SRRM2_uc010bsu.1_Missense_Mutation_p.E105K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	201	Sufficient for RNA-binding.|Lys-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TAGCAGGTCAGAGAGCAGCTC	0.453													0	0	0	0.006122	0	18	35										A	2808993	G	A	2808993	3	1	97	1	0	0	0	0	1	0	0	0	15168	943	33	1	619	1	SRRM2	16	2808993	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1413901	2808993	87545760	384	29872										
OR1F1	4992	broad.mit.edu	37	chr16	3254779	3254779	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caatgccatcactcacttctTctgcgatgtgactcccctac	5	16	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:3254779T>C	uc010uwu.1	+	1	533	c.533T>C	c.(532-534)TTC>TCC	p.F178S		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTCACTTCTTCTGCGATGTG	0.507													0	0	0	0.006999	0	41	110										C	3254779	T	C	3254779	3	2	97	1	0	0	0	0	1	0	0	0	10956	1783	62	5	535	5	OR1F1	16	3254779	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	445786	3254779	87099974	385	29873										
NAGPA	51172	broad.mit.edu	37	chr16	5083318	5083318	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cggatcccgaactgcgcgttCtgcagccccccggagctgct	12	17	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:5083318C>T	uc002cyg.2	-	2	519	c.498G>A	c.(496-498)CAG>CAA	p.Q166Q	ALG1_uc002cyj.2_5'Flank|NAGPA_uc002cyf.2_Silent_p.Q24Q|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_Silent_p.Q24Q|NAGPA_uc010uxx.1_Intron	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	166	Lumenal (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	ACTGCGCGTTCTGCAGCCCCC	0.697													0	0	0	0.003163	0	14	22										T	5083318	C	T	5083318	2	4	97	1	0	0	0	0	0	0	0	1	10144	912	32	1		1	NAGPA	16	5083318	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1828539	5083318	85271435	386	29874										
ALG1	56052	broad.mit.edu	37	chr16	5123184	5123184	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agttttccagtacggagtcaAagttgtacttcaggctatgt	10	7	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:5123184A>T	uc002cym.2	+	3	358	c.317A>T	c.(316-318)AAA>ATA	p.K106I	ALG1_uc002cyj.2_5'UTR|ALG1_uc002cyn.2_Missense_Mutation_p.K106I|ALG1_uc010bue.2_5'UTR|ALG1_uc010uxy.1_5'UTR	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	106	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				TACGGAGTCAAAGTTGTACTT	0.507													0	0	0	0.00499	0	16	72										T	5123184	A	T	5123184	3	4	97	1	0	0	0	0	1	0	0	0	510	14	1	5	327	5	ALG1	16	5123184	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	39866	5123184	85231569	387	29875										
GRIN2A	2903	broad.mit.edu	37	chr16	9857968	9857968	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtaggggtccgggaagtccaCgttctcgggcagggtcacat	16	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:9857968C>T	uc002czo.3	-	13	3981	c.3433G>A	c.(3433-3435)GTG>ATG	p.V1145M	GRIN2A_uc010uym.1_Missense_Mutation_p.V1145M|GRIN2A_uc010uyn.1_Missense_Mutation_p.V988M|GRIN2A_uc002czr.3_Missense_Mutation_p.V1145M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1145	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGGAAGTCCACGTTCTCGGGC	0.537													0	0	0	0.00361	0	48	168										T	9857968	C	T	9857968	3	4	97	1	0	0	0	0	1	0	0	0	6779	536	19	2	965	2	GRIN2A	16	9857968	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4734784	9857968	80496785	388	29876										
SMG1	23049	broad.mit.edu	37	chr16	18864945	18864945	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgaggatactcttcttccatCgtattaacagatggcagttc	8	10	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:18864945C>T	uc002dfm.2	-	31	5091	c.4728G>A	c.(4726-4728)ACG>ACA	p.T1576T	SMG1_uc010bwb.2_Silent_p.T1436T|SMG1_uc010bwa.2_Silent_p.T307T	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1576	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CTTCTTCCATCGTATTAACAG	0.348													0	0	0	0.001984	0	7	25										T	18864945	C	T	18864945	2	4	97	1	0	0	0	0	0	0	0	1	14795	871	31	1		1	SMG1	16	18864945	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	9006977	18864945	71489808	389	29877										
CP110	9738	broad.mit.edu	37	chr16	19539318	19539318	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtatctcacttattcgctttCatggagtggctatcctttct	7	10	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:19539318C>T	uc002dgl.3	+	2	362	c.115C>T	c.(115-117)CAT>TAT	p.H39Y	CP110_uc002dgk.3_Missense_Mutation_p.H39Y			O43303	CP110_HUMAN	RecName: Full=Centrosomal protein of 110 kDa;          Short=Cep110;	39	CEP97 binding.				centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding				0						TATTCGCTTTCATGGAGTGGC	0.333													0	0	0	0.003755	0	30	78										T	19539318	C	T	19539318	3	4	97	1	0	0	0	0	1	0	0	0	3788	826	29	1	117	1	CP110	16	19539318	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	674373	19539318	70815435	390	29878										
C16orf62	57020	broad.mit.edu	37	chr16	19656273	19656273	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	taatggatttataaaaatggTaagtattagggaagaagttt	10	0	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:19656273T>C	uc002dgn.1	+	23	1941	c.1929_splice	c.e23+2	p.M643_splice	C16orf62_uc002dgo.1_Splice_Site_p.M576_splice|C16orf62_uc002dgp.1_Splice_Site_p.M392_splice	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020							integral to membrane				ovary(1)	1						ATAAAAATGGTAAGTATTAGG	0.338													0	0	0	0.006122	0	16	51										C	19656273	T	C	19656273	5	2	97	1	0	0	0	0	0	0	1	0	1825	1652	57	5	2021	5	C16orf62	16	19656273	Splice_Site	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	116955	19656273	70698480	391	29879										
PDILT	204474	broad.mit.edu	37	chr16	20410448	20410448	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caccatgaggaagcgggtctGgttcagcatctgggtcaggc	15	10	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:20410448G>T	uc002dhc.1	-	2	398	c.175C>A	c.(175-177)CAG>AAG	p.Q59K		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	59					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						AAGCGGGTCTGGTTCAGCATC	0.587													1	0	9.39395e-14	0.00632	1.21358e-13	27	77										T	20410448	G	T	20410448	3	4	97	1	0	0	0	0	1	0	0	0	11674	1357	47	4	1623	4	PDILT	16	20410448	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	754175	20410448	69944305	392	29880										
DNAH3	55567	broad.mit.edu	37	chr16	20975839	20975839	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gttttcaatcaagacaggggTgcctaactgcagcgcgtttt	11	9	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:20975839T>C	uc010vbe.1	-	53	9367	c.9367A>G	c.(9367-9369)ACC>GCC	p.T3123A	DNAH3_uc010vbd.1_Missense_Mutation_p.T558A	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3123	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AAGACAGGGGTGCCTAACTGC	0.438													0	0	0	0.00361	0	62	197										C	20975839	T	C	20975839	3	2	97	1	0	0	0	0	1	0	0	0	4603	1696	59	5	3022	5	DNAH3	16	20975839	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	565391	20975839	69378914	393	29881										
GTF3C1	2975	broad.mit.edu	37	chr16	27472877	27472877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccggatgcagccgagggactCcaggccctggagacaccaga	14	14	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:27472877C>T	uc002dov.1	-	37	6164	c.6124G>A	c.(6124-6126)GAG>AAG	p.E2042K	GTF3C1_uc002dou.2_Missense_Mutation_p.E2017K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	2042						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCGAGGGACTCCAGGCCCTGG	0.493													0	0	0	0.004656	0	23	55										T	27472877	C	T	27472877	3	4	97	1	0	0	0	0	1	0	0	0	6872	864	30	1	209	1	GTF3C1	16	27472877	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	6497038	27472877	62881876	394	29882										
SH2B1	25970	broad.mit.edu	37	chr16	28883959	28883959	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttccgggtgcaccccatcccTttggagtcgggaggctccag	13	14	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:28883959T>A	uc002dri.2	+	10	2269	c.1830T>A	c.(1828-1830)CCT>CCA	p.P610P	uc010vct.1_Intron|SH2B1_uc010vdc.1_Silent_p.P300P|SH2B1_uc002drj.2_Silent_p.P610P|SH2B1_uc002drk.2_Silent_p.P610P|SH2B1_uc002drl.2_Silent_p.P610P|SH2B1_uc010vdd.1_Silent_p.P274P|SH2B1_uc010vde.1_Silent_p.P610P|SH2B1_uc002drm.2_Silent_p.P610P	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	610	SH2.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						ACCCCATCCCTTTGGAGTCGG	0.602													0	0	0	0.002222	0	42	90										A	28883959	T	A	28883959	2	1	97	1	0	0	0	0	0	0	0	1	14227	1596	56	5		5	SH2B1	16	28883959	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	1411082	28883959	61470794	395	29883										
ATP2A1	487	broad.mit.edu	37	chr16	28914209	28914209	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgtccgtgctggtgaccatCgagatgtgcaatgcactgaa	12	10	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:28914209C>T	uc002dro.1	+	19	2905	c.2721C>T	c.(2719-2721)ATC>ATT	p.I907I	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.I907I|ATP2A1_uc002drp.1_Silent_p.I782I	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	907	Helical; Name=8; (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGTGACCATCGAGATGTGCA	0.637													0	0	0	0.003163	0	16	30										T	28914209	C	T	28914209	2	4	97	1	0	0	0	0	0	0	0	1	1136	874	31	1		1	ATP2A1	16	28914209	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	30250	28914209	61440544	396	29884										
NFATC2IP	84901	broad.mit.edu	37	chr16	28963486	28963486	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttcgccttatcccagatgatCtatccctcctgaaactctac	4	15	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:28963486C>G	uc002dru.2	+	2	436	c.421C>G	c.(421-423)CTA>GTA	p.L141V	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Translation_Start_Site|NFATC2IP_uc010vdg.1_Missense_Mutation_p.L141V	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	141						cytoplasm|nucleus				ovary(1)	1						CCCAGATGATCTATCCCTCCT	0.542													0	0	0	0.00361	0	48	106										G	28963486	C	G	28963486	3	3	97	1	0	0	0	0	1	0	0	0	10363	912	32	1	427	1	NFATC2IP	16	28963486	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	49277	28963486	61391267	397	29885										
TAOK2	9344	broad.mit.edu	37	chr16	29994162	29994162	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgcagtaccgcaagatgaaGaagatcctgttccaagaggc	11	10	0	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:29994162G>A	uc002dva.1	+	11	1722	c.939G>A	c.(937-939)AAG>AAA	p.K313K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Silent_p.K313K|TAOK2_uc002dvc.1_Silent_p.K313K|TAOK2_uc010bzm.1_Silent_p.K313K|TAOK2_uc002dvd.1_Silent_p.K140K	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	313					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCAAGATGAAGAAGATCCTGT	0.602													0	0	0	0.004289	0	36	97										A	29994162	G	A	29994162	2	1	97	1	0	0	0	0	0	0	0	1	15545	933	33	1		1	TAOK2	16	29994162	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1030676	29994162	60360591	398	29886										
PRSS36	146547	broad.mit.edu	37	chr16	31157215	31157215	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggctgtagagacattgacaGgtggcctcgcccagcagcct	13	12	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:31157215G>A	uc002ebd.2	-	6	674	c.615C>T	c.(613-615)ACC>ACT	p.T205T	PRSS36_uc010vff.1_5'UTR|PRSS36_uc010vfg.1_Silent_p.T205T|PRSS36_uc010vfh.1_Silent_p.T205T	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	205	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						GACATTGACAGGTGGCCTCGC	0.612													0	0	0	0.001855	0	14	41										A	31157215	G	A	31157215	2	1	97	1	0	0	0	0	0	0	0	1	12625	987	35	2		2	PRSS36	16	31157215	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1163053	31157215	59197538	399	29887										
ITGAM	3684	broad.mit.edu	37	chr16	31288291	31288291	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tatgactgggctggtggagtCtttctatatacatcaaagga	11	6	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:31288291C>G	uc002ebq.2	+	11	1232	c.1134C>G	c.(1132-1134)GTC>GTG	p.V378V	ITGAM_uc002ebr.2_Silent_p.V378V|ITGAM_uc010cam.1_Silent_p.V29V	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	378	FG-GAP 3.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						CTGGTGGAGTCTTTCTATATA	0.498													0	0	0	0.000978	0	12	18										G	31288291	C	G	31288291	2	3	97	1	0	0	0	0	0	0	0	1	7887	900	32	1		1	ITGAM	16	31288291	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	131076	31288291	59066462	400	29888										
COQ9	57017	broad.mit.edu	37	chr16	57492236	57492236	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcatggtggatgacatgtggCattacgctggggaccagtcc	15	9	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:57492236C>G	uc002elq.2	+	6	701	c.685C>G	c.(685-687)CAT>GAT	p.H229D	COQ9_uc002elr.2_Missense_Mutation_p.H194D|COQ9_uc002els.2_Missense_Mutation_p.H22D	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	229					ubiquinone biosynthetic process	mitochondrion				breast(1)	1						TGACATGTGGCATTACGCTGG	0.547													0	0	0	0.000602	0	4	7										G	57492236	C	G	57492236	3	3	97	1	0	0	0	0	1	0	0	0	3751	710	25	4	707	4	COQ9	16	57492236	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	26203945	57492236	32862517	401	29889										
POLR2C	5432	broad.mit.edu	37	chr16	57496641	57496641	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtggcccctgggcgagatgcCgtacgccaaccagcctaccg	13	16	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:57496641C>T	uc002elt.1	+	1	91	c.5C>T	c.(4-6)CCG>CTG	p.P2L	POLR2C_uc010vhq.1_Missense_Mutation_p.P2L	NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	2					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						GGCGAGATGCCGTACGCCAAC	0.652											OREG0023826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	14										T	57496641	C	T	57496641	3	4	97	1	0	0	0	0	1	0	0	0	12216	652	23	2	7	2	POLR2C	16	57496641	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4405	57496641	32858112	402	29890										
GPR114	221188	broad.mit.edu	37	chr16	57596033	57596033	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actgtggtgcccttttcctgTgcctgtgccttctgactttg	10	12	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:57596033T>C	uc002elx.3	+	2	113	c.28T>C	c.(28-30)TGC>CGC	p.C10R	GPR114_uc010vhr.1_Missense_Mutation_p.C10R|GPR114_uc002ely.2_Missense_Mutation_p.C10R	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	10					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CCTTTTCCTGTGCCTGTGCCT	0.552													0	0	0	0.004289	0	36	76										C	57596033	T	C	57596033	3	2	97	1	0	0	0	0	1	0	0	0	6631	1696	59	5	30	5	GPR114	16	57596033	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	99392	57596033	32758720	403	29891										
CNOT1	23019	broad.mit.edu	37	chr16	58621689	58621689	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aatagtaataccaaccttctGatagtgcaatggattatcaa	6	7	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:58621689G>A	uc002env.2	-	4	597	c.304C>T	c.(304-306)CAG>TAG	p.Q102*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.Q102*|CNOT1_uc002enx.2_Nonsense_Mutation_p.Q102*|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	102					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CCAACCTTCTGATAGTGCAAT	0.363													0	0	0	0.003954	0	24	57										A	58621689	G	A	58621689	4	1	97	1	0	0	0	0	0	1	0	0	3617	1299	45	1	7232	1	CNOT1	16	58621689	Nonsense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1025656	58621689	31733064	404	29892										
KCTD19	146212	broad.mit.edu	37	chr16	67323569	67323569	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcatcggccatatttcctgGcgaagggcagtgtaagctgg	14	9	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:67323569G>T	uc002esu.2	-	16	2735	c.2684C>A	c.(2683-2685)GCC>GAC	p.A895D	KCTD19_uc002est.2_Missense_Mutation_p.A667D|KCTD19_uc010vjj.1_Missense_Mutation_p.A638D	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	895						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		ATATTTCCTGGCGAAGGGCAG	0.542													1	0	0.000219431	0.00245	0.000266672	15	64										T	67323569	G	T	67323569	3	4	97	1	0	0	0	0	1	0	0	0	8106	1203	42	4	100	4	KCTD19	16	67323569	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	8701880	67323569	23031184	405	29893										
COG8	84342	broad.mit.edu	37	chr16	69370492	69370492	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcctcttcataataactgttCcggacacaggtgtccatgag	9	11	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:69370492C>G	uc002ewy.2	-	2	572	c.501G>C	c.(499-501)CGG>CGC	p.R167R	COG8_uc002ewz.3_Silent_p.R167R	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	167					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						AATAACTGTTCCGGACACAGG	0.522													0	0	0	0.005443	0	28	62										G	69370492	C	G	69370492	2	3	97	1	0	0	0	0	0	0	0	1	3664	842	30	1		1	COG8	16	69370492	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2046923	69370492	20984261	406	29894										
DDX19B	11269	broad.mit.edu	37	chr16	70367484	70367484	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gattgagaaaatagccaactGagaagctccaccagccactg	9	11	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:70367484G>A	uc002eyo.2	+	12	1568	c.1439G>A	c.(1438-1440)TGA>TAA	p.*480*	DDX19B_uc010vly.1_Intron|DDX19A_uc002eys.2_Intron|DDX19B_uc010vlv.1_Silent_p.*454*|DDX19B_uc010vlw.1_Silent_p.*371*|DDX19B_uc002eyp.2_Silent_p.*449*|DDX19B_uc002eyq.2_Silent_p.*371*|DDX19B_uc002eyr.2_Silent_p.*329*|DDX19B_uc010vlx.1_Silent_p.*329*|uc002eyt.2_Intron	NM_007242	NP_009173	Q9UMR2	DD19B_HUMAN	DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform	480					mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			kidney(1)	1		Ovarian(137;0.0694)				ATAGCCAACTGAGAAGCTCCA	0.537													0	0	0	0.00361	0	130	162										A	70367484	G	A	70367484	2	1	97	1	0	0	0	0	0	0	0	1	4347	1285	45	1		1	DDX19B	16	70367484	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	996992	70367484	19987269	407	29895										
FUK	197258	broad.mit.edu	37	chr16	70506488	70506488	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aacgtgccctggagtgaattCttcaagaggacaggtgttcg	13	8	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:70506488C>T	uc002eyy.2	+	14	1444	c.1386C>T	c.(1384-1386)TTC>TTT	p.F462F	FUK_uc010cft.2_Silent_p.F494F|FUK_uc002eyz.2_5'UTR	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	462						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GGAGTGAATTCTTCAAGAGGA	0.607													0	0	0	0.001984	0	6	17										T	70506488	C	T	70506488	2	4	97	1	0	0	0	0	0	0	0	1	6096	912	32	1		1	FUK	16	70506488	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	139004	70506488	19848265	408	29896										
COG4	25839	broad.mit.edu	37	chr16	70543163	70543163	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtagtccctttgcttgatgaActtgtctaccaccttctcca	6	13	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:70543163A>G	uc002ezc.2	-	7	984	c.973T>C	c.(973-975)TTC>CTC	p.F325L	COG4_uc002ezb.2_5'UTR|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.F325L|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	321					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TGCTTGATGAACTTGTCTACC	0.483													0	0	0	0.006214	0	9	298										G	70543163	A	G	70543163	3	3	97	1	0	0	0	0	1	0	0	0	3660	43	2	5	1448	5	COG4	16	70543163	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	36675	70543163	19811590	409	29897										
ATP2C2	9914	broad.mit.edu	37	chr16	84444355	84444355	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aagagctgaccaagatggttCctccagaatgtaactggtaa	10	8	0	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:84444355C>T	uc002fhx.2	+	6	588	c.499C>T	c.(499-501)CCT>TCT	p.P167S	ATP2C2_uc010chj.2_Missense_Mutation_p.P167S|ATP2C2_uc002fhy.2_Missense_Mutation_p.P184S|ATP2C2_uc002fhz.2_Intron	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	167	Cytoplasmic (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CAAGATGGTTCCTCCAGAATG	0.507													0	0	0	0.002299	0	23	73										T	84444355	C	T	84444355	3	4	97	1	0	0	0	0	1	0	0	0	1144	855	30	1	521	1	ATP2C2	16	84444355	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	13901192	84444355	5910398	410	29898										
TCF25	22980	broad.mit.edu	37	chr16	89962447	89962447	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttccaccccctgttcagtctCaccagtggggcctgccggct	10	17	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr16:89962447C>T	uc002fpb.2	+	9	1060	c.978C>T	c.(976-978)CTC>CTT	p.L326L	TCF25_uc002fpc.2_Silent_p.L91L	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	326					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TGTTCAGTCTCACCAGTGGGG	0.632													0	0	0	0.00245	0	10	35										T	89962447	C	T	89962447	2	4	97	1	0	0	0	0	0	0	0	1	15690	813	29	1		1	TCF25	16	89962447	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5518092	89962447	392306	411	29899										
SGSM2	9905	broad.mit.edu	37	chr17	2264993	2264993	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccgctggcttcctgcgcagtGacaagatggcagccctgttc	12	14	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:2264993G>C	uc002fun.3	+	3	371	c.196G>C	c.(196-198)GAC>CAC	p.D66H	SGSM2_uc002fum.3_Missense_Mutation_p.D66H|SGSM2_uc010vqw.1_Missense_Mutation_p.D66H	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	66	RUN.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CCTGCGCAGTGACAAGATGGC	0.607													0	0	0	0.00245	0	13	61										C	2264993	G	C	2264993	3	2	97	1	0	0	0	0	1	0	0	0	14223	1290	45	1	206	1	SGSM2	17	2264993	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		2264993	78930217	412	29900										
TP53	7157	broad.mit.edu	37	chr17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcgctcatggtgggggcagCgcctcacaacctccgtcatg	13	14	3	0	rs28934578		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	52	36										T	7578406	C	T	7578406	3	4	97	1	0	0	0	0	1	0	0	0	16378	768	27	2	774	2	TP53	17	7578406	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5313413	7578406	73616804	413	29901										
CYB5D1	124637	broad.mit.edu	37	chr17	7761743	7761743	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aacctgctgctgaaacccatCgtggaagttgcaggccagga	12	11	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:7761743C>T	uc002gjb.3	+	2	572	c.183C>T	c.(181-183)ATC>ATT	p.I61I	LSMD1_uc002giz.2_5'Flank|LSMD1_uc002gja.2_5'Flank|CYB5D1_uc010cnn.1_Silent_p.I61I	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	61	Cytochrome b5 heme-binding.						heme binding			skin(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				TGAAACCCATCGTGGAAGTTG	0.542											OREG0024147	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00632	0	28	31										T	7761743	C	T	7761743	2	4	97	1	0	0	0	0	0	0	0	1	4124	874	31	1		1	CYB5D1	17	7761743	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	183337	7761743	73433467	414	29902										
GAS7	8522	broad.mit.edu	37	chr17	10101629	10101629	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgcagcagcgtgatcagctCgcccgcggcgaagcgcagcc	14	16	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:10101629C>T	uc002gmg.1	-	1	240	c.79G>A	c.(79-81)GAG>AAG	p.E27K		NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	27	SH3.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2						GTGATCAGCTCGCCCGCGGCG	0.721			T	MLL	AML*								0	0	0	0.007413	0	18	56										T	10101629	C	T	10101629	3	4	97	1	0	0	0	0	1	0	0	0	6250	893	31	1	1465	1	GAS7	17	10101629	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2339886	10101629	71093581	415	29903										
TOP3A	7156	broad.mit.edu	37	chr17	18217940	18217940	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atgcgaccgtttgacagcagGtcggcgatccccttggccgc	13	14	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:18217940G>C	uc002gsx.1	-	1	382	c.153C>G	c.(151-153)GAC>GAG	p.D51E	SMCR8_uc002gsy.3_5'Flank|TOP3A_uc010vxs.1_5'UTR|TOP3A_uc010cqa.1_RNA	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	51	Toprim.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						TTGACAGCAGGTCGGCGATCC	0.652													0	0	0	0.00499	0	14	41										C	18217940	G	C	18217940	3	2	97	1	0	0	0	0	1	0	0	0	16364	1252	44	4	2928	4	TOP3A	17	18217940	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	8116311	18217940	62977270	416	29904										
CCDC144B	284047	broad.mit.edu	37	chr17	18513444	18513444	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagaagtacaactccagtgtCcattttttctcgttctgtta	7	9	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:18513444C>T	uc002gub.1	-	3	662	c.577G>A	c.(577-579)GAC>AAC	p.D193N	CCDC144B_uc002gua.3_RNA|CCDC144B_uc010vyc.1_RNA|CCDC144B_uc002guc.1_Missense_Mutation_p.D193N	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2						ACTCCAGTGTCCATTTTTTCT	0.418													0	0	0	0.00361	0	65	474										T	18513444	C	T	18513444	3	4	97	1	0	0	0	0	1	0	0	0	2778	855	30	1	1631	1	CCDC144B	17	18513444	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	295504	18513444	62681766	417	29905										
RNF112	7732	broad.mit.edu	37	chr17	19316617	19316617	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctggtgagggcggccggccaAgaggaggagaggcatccctg	19	10	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:19316617A>C	uc010vyw.1	+	5	812	c.613A>C	c.(613-615)AGA>CGA	p.R205R	RNF112_uc010vyu.1_3'UTR|RNF112_uc010vyv.1_Silent_p.R205R|RNF112_uc010vyx.1_Silent_p.R88R	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	205							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						CGGCCGGCCAAGAGGAGGAGA	0.637													0	0	0	0.002299	0	22	50										C	19316617	A	C	19316617	2	2	97	1	0	0	0	0	0	0	0	1	13426	64	3	5		5	RNF112	17	19316617	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	803173	19316617	61878593	418	29906										
SLC47A2	146802	broad.mit.edu	37	chr17	19618059	19618059	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acatcaaggtgtcacatgccGaagacaaaccaactcctaca	6	13	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:19618059G>A	uc002gwe.3	-	3	444	c.269C>T	c.(268-270)TCG>TTG	p.S90L	SLC47A2_uc002gwg.3_Missense_Mutation_p.S90L|SLC47A2_uc002gwf.3_Missense_Mutation_p.S90L|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA|SLC47A2_uc010cqt.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	90	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					GTCACATGCCGAAGACAAACC	0.567													0	0	0	0.00361	0	65	229										A	19618059	G	A	19618059	3	1	97	1	0	0	0	0	1	0	0	0	14648	1059	37	1	1599	1	SLC47A2	17	19618059	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	301442	19618059	61577151	419	29907										
CYTSB	92521	broad.mit.edu	37	chr17	20108350	20108350	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctttgtcgccagatgcttccGactttgagcacattacagca	8	12	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:20108350G>C	uc002gwq.2	+	4	1133	c.988G>C	c.(988-990)GAC>CAC	p.D330H	CYTSB_uc010cqx.2_Missense_Mutation_p.D330H|CYTSB_uc002gwr.2_Missense_Mutation_p.D330H|CYTSB_uc002gws.2_Missense_Mutation_p.D330H|CYTSB_uc002gwv.2_Missense_Mutation_p.D249H|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.D106H|CYTSB_uc002gwt.2_Missense_Mutation_p.D249H|CYTSB_uc002gwu.2_Missense_Mutation_p.D249H	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	330	Ser-rich.			D -> N (in Ref. 5; AAH50058).		nucleus					0						AGATGCTTCCGACTTTGAGCA	0.458													0	0	0	0.006214	0	7	239										C	20108350	G	C	20108350	3	2	97	1	0	0	0	0	1	0	0	0	4210	1058	37	1	1042	1	CYTSB	17	20108350	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	490291	20108350	61086860	420	29908										
SLC46A1	113235	broad.mit.edu	37	chr17	26732963	26732963	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccctttggcgggtgccattgTagccgaggtcggcgctgaag	16	11	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:26732963T>G	uc002hbf.1	-	1	266	c.170A>C	c.(169-171)TAC>TCC	p.Y57S	SLC46A1_uc002hbg.1_Missense_Mutation_p.Y57S|SLC46A1_uc010wak.1_Missense_Mutation_p.Y57S	NM_080669	NP_542400	Q96NT5	PCFT_HUMAN	proton-coupled folate transporter	57					cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	GGTGCCATTGTAGCCGAGGTC	0.692													0	0	0	0.000248	0	3	17										G	26732963	T	G	26732963	3	3	97	1	0	0	0	0	1	0	0	0	14644	1638	57	5	1230	5	SLC46A1	17	26732963	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	6624613	26732963	54462247	421	29909										
TRAF4	9618	broad.mit.edu	37	chr17	27076071	27076071	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aggagctgcaggagcttcggCgagagctggaggagctatca	17	8	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:27076071C>T	uc002hcs.2	+	7	997	c.889C>T	c.(889-891)CGA>TGA	p.R297*	TRAF4_uc002hcq.1_Intron	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	297	Potential.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			GGAGCTTCGGCGAGAGCTGGA	0.617													0	0	0	0.003271	0	34	63										T	27076071	C	T	27076071	4	4	97	1	0	0	0	0	0	1	0	0	16440	760	27	2	915	2	TRAF4	17	27076071	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	343108	27076071	54119139	422	29910										
CCDC55	84081	broad.mit.edu	37	chr17	28506137	28506137	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	attcacaacttgctaaaagcAgttgagatcagaaaaaagga	8	6	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:28506137A>G	uc002heu.2	+	5	358	c.330A>G	c.(328-330)GCA>GCG	p.A110A	CCDC55_uc002hev.2_Silent_p.A56A|CCDC55_uc010wbl.1_Silent_p.A56A|CCDC55_uc010wbm.1_Silent_p.A56A|CCDC55_uc002hex.2_Silent_p.A56A	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	110	Necessary for alternative splicing activity.|Potential.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						TGCTAAAAGCAGTTGAGATCA	0.274													0	0	0	0.006214	0	7	17										G	28506137	A	G	28506137	2	3	97	1	0	0	0	0	0	0	0	1	2825	175	7	5		5	CCDC55	17	28506137	Silent	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1430066	28506137	52689073	423	29911										
ATAD5	79915	broad.mit.edu	37	chr17	29220513	29220513	+	Frame_Shift_Del	DEL	G	G	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caaaaagtatgaattgtcttGctaggaaacactctgaaaga							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:29220513delG	uc002hfs.1	+	21	4988	c.4642delG	c.(4642-4644)GCTfs	p.A1548fs		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1548					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GAATTGTCTTGCTAGGAAACA	0.363																		32	91	---	---								-	29220513	G	-	29220513	7	5	97	1	0	1	0	1	0	0	0	0	1076	1319	46	0	4724	0	ATAD5	17	29220513	Frame_Shift_Del	DEL	G	TCGA-G2-A2ES-01A-11D-A17V-08	714376	29220513	51974697	424	29912										
RHBDL3	162494	broad.mit.edu	37	chr17	30632423	30632423	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggctcttctggaggggtgtAtgctctcgtctctgcccatc	13	12	4	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:30632423A>G	uc002hhe.1	+	7	859	c.845A>G	c.(844-846)TAT>TGT	p.Y282C	RHBDL3_uc010csw.1_Missense_Mutation_p.Y274C|RHBDL3_uc010csx.1_Intron|RHBDL3_uc010csy.1_Missense_Mutation_p.Y184C|RHBDL3_uc002hhf.1_Missense_Mutation_p.Y184C	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	282	Helical; (Potential).				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				GGAGGGGTGTATGCTCTCGTC	0.567													0	0	0	0.004878	0	37	97										G	30632423	A	G	30632423	3	3	97	1	0	0	0	0	1	0	0	0	13323	449	16	5	871	5	RHBDL3	17	30632423	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1411910	30632423	50562787	425	29913										
MMP28	79148	broad.mit.edu	37	chr17	34105915	34105915	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctttgcaaagcgtttcttaCgcctcattttggtccggtgt	10	10	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:34105915C>A	uc002hjy.1	-	3	615	c.356G>T	c.(355-357)CGT>CTT	p.R119L	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA|MMP28_uc002hka.2_Missense_Mutation_p.R119L	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	119					proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCGTTTCTTACGCCTCATTTT	0.507													1	0	4.90274e-10	0.00623	6.17001e-10	37	104										A	34105915	C	A	34105915	3	1	97	1	0	0	0	0	1	0	0	0	9665	536	19	4	1243	4	MMP28	17	34105915	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3473492	34105915	47089295	426	29914										
CCL14	6358	broad.mit.edu	37	chr17	34310878	34310878	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gatatagtcctggacccactTgtcactggggttggtacaga	12	9	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:34310878T>C	uc010wcr.1	-	3	320	c.241A>G	c.(241-243)AAG>GAG	p.K81E	CCL16_uc002hkl.2_5'Flank|CCL16_uc002hkm.2_5'Flank|CCL14_uc010wcq.1_Missense_Mutation_p.K97E|CCL14_uc002hkn.2_RNA|CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA|uc002hkq.2_5'Flank	NM_032963	NP_116739	Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14 isoform 1	81					cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGACCCACTTGTCACTGGGG	0.547													0	0	0	0.003271	0	32	102										C	34310878	T	C	34310878	3	2	97	1	0	0	0	0	1	0	0	0	2885	1821	63	5	44	5	CCL14	17	34310878	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	204963	34310878	46884332	427	29915										
CDC6	990	broad.mit.edu	37	chr17	38458227	38458227	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aagataaagctttaattggaAatatcttagctactggattg	8	4	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:38458227A>G	uc002huj.1	+	12	1867	c.1657A>G	c.(1657-1659)AAT>GAT	p.N553D		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	553					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						TTTAATTGGAAATATCTTAGC	0.363													0	0	0	0.00361	0	48	131										G	38458227	A	G	38458227	3	3	97	1	0	0	0	0	1	0	0	0	3083	14	1	5	1699	5	CDC6	17	38458227	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	4147349	38458227	42736983	428	29916										
TOP2A	7153	broad.mit.edu	37	chr17	38564250	38564251	+	Frame_Shift_Ins	INS	-	-	T													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcttctcgaacattgagtaINStttttcctctaagagggaaa							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:38564250_38564251insT	uc002huq.2	-	12	1594_1595	c.1468_1469insA	c.(1468-1470)ATAfs	p.I490fs	TOP2A_uc002hur.1_Frame_Shift_Ins_p.I131fs	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	490					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	AACATTGAGTATTTTTCCTCTA	0.371																		54	216	---	---								T	38564251	-	T	38564250	7	5	97	1	0	1	1	0	0	0	0	0	16362	449	16	0	3222	0	TOP2A	17	38564250	Frame_Shift_Ins	INS	-	TCGA-G2-A2ES-01A-11D-A17V-08	106023	38564250	42630960	429	29917										
TOP2A	7153	broad.mit.edu	37	chr17	38567656	38567656	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gttcttcttcttcacaacatCaacaagtttagtcacaatct	3	11	7	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:38567656C>T	uc002huq.2	-	9	1141	c.1015G>A	c.(1015-1017)GAT>AAT	p.D339N	TOP2A_uc002hur.1_5'UTR	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	339					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTCACAACATCAACAAGTTTA	0.358													0	0	0	0.00361	0	58	287										T	38567656	C	T	38567656	3	4	97	1	0	0	0	0	1	0	0	0	16362	826	29	1	3688	1	TOP2A	17	38567656	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3406	38567656	42627554	430	29918										
KRTAP1-5	83895	broad.mit.edu	37	chr17	39183134	39183134	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accaatgccacagccagttcCgcaggagctgatctggcagc	11	14	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:39183134C>T	uc002hvu.2	-	1	321	c.274G>A	c.(274-276)GGA>AGA	p.G92R		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	92	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGCCAGTTCCGCAGGAGCTG	0.627													0	0	0	0.001984	0	7	62										T	39183134	C	T	39183134	3	4	97	1	0	0	0	0	1	0	0	0	8504	661	23	2	254	2	KRTAP1-5	17	39183134	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	615478	39183134	42012076	431	29919										
JUP	3728	broad.mit.edu	37	chr17	39925391	39925391	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accagctggggcgagcccatCagggcccgccgcgacgcctc	14	18	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:39925391C>T	uc002hxq.2	-	4	814	c.537G>A	c.(535-537)CTG>CTA	p.L179L	JUP_uc010wfs.1_Silent_p.L179L|JUP_uc002hxr.2_Silent_p.L179L|JUP_uc002hxs.2_Silent_p.L179L	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	179					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCGAGCCCATCAGGGCCCGCC	0.657													0	0	0	0.004007	0	16	42										T	39925391	C	T	39925391	2	4	97	1	0	0	0	0	0	0	0	1	7972	813	29	1		1	JUP	17	39925391	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	742257	39925391	41269819	432	29920										
ACLY	47	broad.mit.edu	37	chr17	40025748	40025748	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttcgaggtggtaatcttctcTacttccagtgcataatcgag	9	9	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:40025748T>A	uc002hyg.2	-	26	3193	c.3030A>T	c.(3028-3030)GTA>GTT	p.V1010V	ACLY_uc002hyh.2_Silent_p.V1000V|ACLY_uc002hyi.2_Silent_p.V1064V|ACLY_uc010wfx.1_Silent_p.V1054V|ACLY_uc010wfy.1_Silent_p.V739V	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	1010					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TAATCTTCTCTACTTCCAGTG	0.438													0	0	0	0.00361	0	45	107										A	40025748	T	A	40025748	2	1	97	1	0	0	0	0	0	0	0	1	143	1509	53	5		5	ACLY	17	40025748	Silent	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	100357	40025748	41169462	433	29921										
WNK4	65266	broad.mit.edu	37	chr17	40947024	40947024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccacaccccaccagctctcCacttccattctcctccagca	2	22	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:40947024C>T	uc002ibj.2	+	14	2606	c.2585C>T	c.(2584-2586)CCA>CTA	p.P862L	WNK4_uc010wgx.1_Missense_Mutation_p.P526L|WNK4_uc002ibk.1_Missense_Mutation_p.P634L	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	862					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		ACCAGCTCTCCACTTCCATTC	0.582													0	0	0	0.00361	0	51	121										T	40947024	C	T	40947024	3	4	97	1	0	0	0	0	1	0	0	0	17377	594	21	2	2639	2	WNK4	17	40947024	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	921276	40947024	40248186	434	29922										
C17orf57	124989	broad.mit.edu	37	chr17	45455230	45455230	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caggaattaatttattagatGaagaattccagaagattgtg	9	3	0	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:45455230G>A	uc002iln.2	+	13	1882	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	C17orf57_uc002ilm.2_Missense_Mutation_p.E395K|C17orf57_uc010daz.1_Missense_Mutation_p.E443K	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	491	EF-hand 1.						calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TTTATTAGATGAAGAATTCCA	0.323													0	0	0	0.00278	0	22	71										A	45455230	G	A	45455230	3	1	97	1	0	0	0	0	1	0	0	0	1865	1291	45	1	1509	1	C17orf57	17	45455230	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4508206	45455230	35739980	435	29923										
SPATA20	64847	broad.mit.edu	37	chr17	48628506	48628506	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcttccaggcccggaagcatCggcccaagccgcacctggac	11	17	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:48628506C>T	uc002irf.2	+	11	1624	c.1483C>T	c.(1483-1485)CGG>TGG	p.R495W	SPATA20_uc002irc.2_Missense_Mutation_p.R162W|SPATA20_uc002ire.2_Missense_Mutation_p.R451W|SPATA20_uc002ird.2_Missense_Mutation_p.R511W|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	495					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CCGGAAGCATCGGCCCAAGCC	0.627											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	21										T	48628506	C	T	48628506	3	4	97	1	0	0	0	0	1	0	0	0	15005	875	31	1	1577	1	SPATA20	17	48628506	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	3173276	48628506	32566704	436	29924										
SFRS1	6426	broad.mit.edu	37	chr17	56082801	56082801	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagatctgctatgacggggaGaatagcgtggtgatcctctg	15	7	2	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:56082801G>A	uc002ivi.2	-	4	922	c.713C>T	c.(712-714)TCT>TTT	p.S238F	SFRS1_uc002ivj.2_3'UTR	NM_006924	NP_008855	Q07955	SRSF1_HUMAN	splicing factor, arginine/serine-rich 1 isoform	238	Arg/Ser-rich (RS domain).|Interacts with SAFB1.			Missing: In RS-C; loss of ability to activate splicing but retains splice site switching.|Missing: In MR-A; loss of ability to activate splicing.|Missing: In MR-B; strongly inhibits splicing.|Missing: In RS-B; retains both splice activation and splice site switching activity.	mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA 5'-splice site recognition|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytoplasm|nuclear speck	nucleotide binding|RNA binding				0		Colorectal(1115;0.0691)		LUAD - Lung adenocarcinoma(1115;0.247)		ATGACGGGGAGAATAGCGTGG	0.468													0	0	0	0.00361	0	57	178										A	56082801	G	A	56082801	3	1	97	1	0	0	0	0	1	0	0	0	14165	942	33	1	37	1	SFRS1	17	56082801	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	7454295	56082801	25112409	437	29925										
CLTC	1213	broad.mit.edu	37	chr17	57763022	57763022	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctgcagtggtttttgcaggaAgaaaaaagagagtgctttgg	14	4	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:57763022A>C	uc002ixq.1	+	30	5123	c.4680A>C	c.(4678-4680)GAA>GAC	p.E1560D	CLTC_uc002ixp.2_Missense_Mutation_p.E1560D|CLTC_uc002ixr.1_Missense_Mutation_p.E1564D	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	1560	Heavy chain arm.|Proximal segment.|Trimerization (By similarity).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TTTTGCAGGAAGAAAAAAGAG	0.398			T	ALK|TFE3	ALCL|renal 								0	0	0	0.007835	0	38	110										C	57763022	A	C	57763022	3	2	97	1	0	0	0	0	1	0	0	0	3566	69	3	5	4798	5	CLTC	17	57763022	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1680221	57763022	23432188	438	29926										
CSHL1	1444	broad.mit.edu	37	chr17	61987572	61987572	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtcctttaggaggtgatagtCatcgctgtccgaggtgtcat	13	8	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:61987572C>T	uc002jda.1	-	4	483	c.421G>A	c.(421-423)GAC>AAC	p.D141N	CSHL1_uc002jcz.1_Missense_Mutation_p.D118N|CSHL1_uc002jdb.1_Missense_Mutation_p.D47N|CSHL1_uc002jdc.1_Missense_Mutation_p.D58N|CSHL1_uc002jdd.1_Missense_Mutation_p.D79N|CSHL1_uc002jde.2_3'UTR|CSHL1_uc002jdf.2_Missense_Mutation_p.D58N|CSHL1_uc002jdg.2_3'UTR|CSHL1_uc002jdh.2_Missense_Mutation_p.D47N	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	141						extracellular region	hormone activity|metal ion binding				0						AGGTGATAGTCATCGCTGTCC	0.592													0	0	0	0.002222	0	38	84										T	61987572	C	T	61987572	3	4	97	1	0	0	0	0	1	0	0	0	3942	826	29	1	255	1	CSHL1	17	61987572	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4224550	61987572	19207638	439	29927										
RGS9	8787	broad.mit.edu	37	chr17	63156668	63156668	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttgcagacaccgtatttctgGcccacccagcagtggccagc	10	15	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:63156668G>A	uc002jfe.2	+	5	437	c.327G>A	c.(325-327)TGG>TGA	p.W109*	RGS9_uc010dem.2_Nonsense_Mutation_p.W109*|RGS9_uc002jfd.2_Nonsense_Mutation_p.W109*|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	109					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CGTATTTCTGGCCCACCCAGC	0.468													0	0	0	0.004007	0	17	45										A	63156668	G	A	63156668	4	1	97	1	0	0	0	0	0	1	0	0	13313	1212	42	2	345	2	RGS9	17	63156668	Nonsense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1169096	63156668	18038542	440	29928										
ABCA5	23461	broad.mit.edu	37	chr17	67257837	67257837	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ttttcttaaaggtgaaagaaGcaatataagtgaacagaata	8	3	1	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:67257837G>A	uc002jif.2	-	24	4586	c.3368C>T	c.(3367-3369)GCT>GTT	p.A1123V	ABCA5_uc002jib.2_Missense_Mutation_p.A89V|ABCA5_uc002jic.2_Missense_Mutation_p.A346V|ABCA5_uc002jid.2_Missense_Mutation_p.A40V|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.A1123V	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1123					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GGTGAAAGAAGCAATATAAGT	0.274													0	0	0	0.000978	0	9	25										A	67257837	G	A	67257837	3	1	97	1	0	0	0	0	1	0	0	0	35	971	34	2	1620	2	ABCA5	17	67257837	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4101169	67257837	13937373	441	29929										
TTYH2	94015	broad.mit.edu	37	chr17	72249233	72249233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gttctagaaacagagactacGatgacattgatgatgatgac	10	6	1	7			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:72249233G>A	uc002jkc.2	+	12	1304	c.1273G>A	c.(1273-1275)GAT>AAT	p.D425N	TTYH2_uc010wqw.1_Missense_Mutation_p.D404N|TTYH2_uc002jkd.2_Missense_Mutation_p.D104N	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	425	Cytoplasmic (Potential).|Poly-Asp.					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						CAGAGACTACGATGACATTGA	0.572													0	0	0	0.00361	0	72	172										A	72249233	G	A	72249233	3	1	97	1	0	0	0	0	1	0	0	0	16737	1058	37	1	1319	1	TTYH2	17	72249233	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4991396	72249233	8945977	442	29930										
DNAI2	64446	broad.mit.edu	37	chr17	72308171	72308171	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgtgagacccggcgagagaaGatcctggaggccaggcaccg	16	12	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:72308171G>C	uc002jkf.2	+	12	1623	c.1524G>C	c.(1522-1524)AAG>AAC	p.K508N	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_5'Flank|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	508					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						GGCGAGAGAAGATCCTGGAGG	0.657									Kartagener_syndrome				0	0	0	0.00632	0	24	44										C	72308171	G	C	72308171	3	2	97	1	0	0	0	0	1	0	0	0	4610	933	33	1	1566	1	DNAI2	17	72308171	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	58938	72308171	8887039	443	29931										
GRIN2C	2905	broad.mit.edu	37	chr17	72838777	72838777	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctggcacagggtggaaggtGaggacagacagccccccagc	16	12	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:72838777G>A	uc002jlt.1	-	13	3655	c.3499C>T	c.(3499-3501)CAC>TAC	p.H1167Y	GRIN2C_uc010wrh.1_RNA	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	1167	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GGTGGAAGGTGAGGACAGACA	0.711													0	0	0	0.001168	0	6	11										A	72838777	G	A	72838777	3	1	97	1	0	0	0	0	1	0	0	0	6781	1290	45	1	206	1	GRIN2C	17	72838777	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	530606	72838777	8356433	444	29932										
KIAA0195	9772	broad.mit.edu	37	chr17	73489996	73489996	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgcagcagctggagctctgaCggtacctcatgggtctgtcc	13	13	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:73489996C>T	uc002jnz.3	+	18	2681	c.2406C>T	c.(2404-2406)GAC>GAT	p.D802D	KIAA0195_uc010wsa.1_Silent_p.D812D|KIAA0195_uc010wsb.1_Silent_p.D442D|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	802					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGAGCTCTGACGGTACCTCAT	0.692													0	0	0	0.001368	0	7	29										T	73489996	C	T	73489996	2	4	97	1	0	0	0	0	0	0	0	1	8160	550	19	2		2	KIAA0195	17	73489996	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	651219	73489996	7705214	445	29933										
LLGL2	3993	broad.mit.edu	37	chr17	73559178	73559178	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cctcgagaccccaaccagatCctgatcggctacagccgagg	10	16	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:73559178C>T	uc002joh.2	+	7	766	c.612C>T	c.(610-612)ATC>ATT	p.I204I	LLGL2_uc002jog.1_Silent_p.I204I|LLGL2_uc010dgf.1_Silent_p.I204I|LLGL2_uc002joi.2_Silent_p.I204I|LLGL2_uc010dgg.1_Silent_p.I204I|LLGL2_uc002joj.2_Silent_p.I193I|LLGL2_uc010wsd.1_5'Flank|uc002jok.2_5'Flank	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	204	WD 4.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CCAACCAGATCCTGATCGGCT	0.657													0	0	0	0.00632	0	26	36										T	73559178	C	T	73559178	2	4	97	1	0	0	0	0	0	0	0	1	8834	845	30	1		1	LLGL2	17	73559178	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	69182	73559178	7636032	446	29934										
LLGL2	3993	broad.mit.edu	37	chr17	73559467	73559467	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cctgctcgtcagctgtcactCtgacggcagctactgccagt	10	15	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:73559467C>G	uc002joh.2	+	8	903	c.749C>G	c.(748-750)TCT>TGT	p.S250C	LLGL2_uc002jog.1_Missense_Mutation_p.S250C|LLGL2_uc010dgf.1_Missense_Mutation_p.S250C|LLGL2_uc002joi.2_Missense_Mutation_p.S250C|LLGL2_uc010dgg.1_Missense_Mutation_p.S250C|LLGL2_uc002joj.2_Missense_Mutation_p.S239C|LLGL2_uc010wsd.1_5'Flank|uc002jok.2_5'Flank	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	250	WD 5.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AGCTGTCACTCTGACGGCAGC	0.652													0	0	0	0.007413	0	17	61										G	73559467	C	G	73559467	3	3	97	1	0	0	0	0	1	0	0	0	8834	913	32	1	775	1	LLGL2	17	73559467	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	289	73559467	7635743	447	29935										
EVPL	2125	broad.mit.edu	37	chr17	74003727	74003727	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccagtagcttctgcccagtGatggggtccagcatgttctt	11	11	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:74003727G>A	uc002jqi.2	-	22	5787	c.5559C>T	c.(5557-5559)ATC>ATT	p.I1853I	EVPL_uc010wss.1_Silent_p.I1875I|EVPL_uc010wst.1_Silent_p.I1323I	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1853	Globular 2.|Plectin 3.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TCTGCCCAGTGATGGGGTCCA	0.612													0	0	0	0.00361	0	58	155										A	74003727	G	A	74003727	2	1	97	1	0	0	0	0	0	0	0	1	5292	1280	45	1		1	EVPL	17	74003727	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	444260	74003727	7191483	448	29936										
SRP68	6730	broad.mit.edu	37	chr17	74068493	74068493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cggcaccacgtccaccgccgCtaccgccgccgccactgcca	9	23	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:74068493C>T	uc002jqk.1	-	1	115	c.80G>A	c.(79-81)AGC>AAC	p.S27N	SRP68_uc010wsu.1_5'UTR|SRP68_uc002jql.1_Missense_Mutation_p.S27N|GALR2_uc002jqm.1_5'Flank	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	27				Missing (in Ref. 1).	response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						Tccaccgccgctaccgccgcc	0.378													0	0	0	0.008361	0	25	48										T	74068493	C	T	74068493	3	4	97	1	0	0	0	0	1	0	0	0	15155	797	28	2	1867	2	SRP68	17	74068493	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	64766	74068493	7126717	449	29937										
EXOC7	23265	broad.mit.edu	37	chr17	74085384	74085384	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtaggcatcggtctccacgtCcagcatgtcatctctccctg	9	15	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:74085384C>A	uc002jqs.2	-	9	1167	c.1072G>T	c.(1072-1074)GAC>TAC	p.D358Y	EXOC7_uc010dgv.1_Missense_Mutation_p.D254Y|EXOC7_uc002jqq.2_Missense_Mutation_p.D307Y|EXOC7_uc010wsw.1_Missense_Mutation_p.D330Y|EXOC7_uc010wsx.1_Missense_Mutation_p.D299Y|EXOC7_uc002jqr.2_Missense_Mutation_p.D276Y|EXOC7_uc010wsv.1_Missense_Mutation_p.D266Y	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	358					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			GTCTCCACGTCCAGCATGTCA	0.647													1	0	4.96729e-08	0.008871	6.16165e-08	20	32										A	74085384	C	A	74085384	3	1	97	1	0	0	0	0	1	0	0	0	5310	855	30	3	1183	3	EXOC7	17	74085384	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	16891	74085384	7109826	450	29938										
USP36	57602	broad.mit.edu	37	chr17	76817134	76817134	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccgagacgctcttgcacacgGagcacttcactgcaacagaa	9	14	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:76817134G>T	uc002jvz.1	-	8	1092	c.767C>A	c.(766-768)TCC>TAC	p.S256Y	USP36_uc002jwa.1_Missense_Mutation_p.S256Y|USP36_uc002jwc.1_5'UTR	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	256					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CTTGCACACGGAGCACTTCAC	0.607													1	0	2.0095e-06	0.001984	2.46908e-06	7	3										T	76817134	G	T	76817134	3	4	97	1	0	0	0	0	1	0	0	0	17064	1174	41	3	2656	3	USP36	17	76817134	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2731750	76817134	4378076	451	29939										
CARD14	79092	broad.mit.edu	37	chr17	78166356	78166356	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cacgggagaagcagcggctgGtgcggatgcatgccatctgc	16	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:78166356G>T	uc002jxw.1	+	9	1489	c.1294G>T	c.(1294-1296)GTG>TTG	p.V432L	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.V432L|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Missense_Mutation_p.V195L|CARD14_uc010dhu.1_Missense_Mutation_p.V230L	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	432					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCAGCGGCTGGTGCGGATGCA	0.637													1	0	1.64293e-13	0.00333	2.11895e-13	25	72										T	78166356	G	T	78166356	3	4	97	1	0	0	0	0	1	0	0	0	2646	1261	44	4	1324	4	CARD14	17	78166356	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1349222	78166356	3028854	452	29940										
CHMP6	79643	broad.mit.edu	37	chr17	78970862	78970862	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgagacgcaggaggccgtggAgtaccagcgggtaggtggca	19	9	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:78970862A>G	uc002jyw.3	+	5	482	c.404A>G	c.(403-405)GAG>GGG	p.E135G		NM_024591	NP_078867	Q96FZ7	CHMP6_HUMAN	chromatin modifying protein 6	135	Potential.				cellular membrane organization|endosome transport|protein transport	cytosol|endomembrane system|late endosome membrane	protein N-terminus binding			ovary(1)	1	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0175)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GAGGCCGTGGAGTACCAGCGG	0.632													0	0	0	0.00245	0	15	41										G	78970862	A	G	78970862	3	3	97	1	0	0	0	0	1	0	0	0	3360	304	11	5	422	5	CHMP6	17	78970862	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	804506	78970862	2224348	453	29941										
HGS	9146	broad.mit.edu	37	chr17	79668080	79668080	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtcttctcacaacagaatctCatgaccaccctcccaagcca	4	17	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:79668080C>T	uc002kbg.2	+	21	2219	c.2142C>T	c.(2140-2142)CTC>CTT	p.L714L	MRPL12_uc002kbh.1_5'Flank|SLC25A10_uc010wut.1_5'Flank	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	714	Interaction with NF2.|Gln-rich.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			AACAGAATCTCATGACCACCC	0.602													0	0	0	0.001523	0	20	71										T	79668080	C	T	79668080	2	4	97	1	0	0	0	0	0	0	0	1	7087	813	29	1		1	HGS	17	79668080	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	697218	79668080	1527130	454	29942										
NOTUM	147111	broad.mit.edu	37	chr17	79916822	79916822	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cccccttacaccatgtttgcGttccaccagtaggggttctc	8	15	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr17:79916822G>A	uc010wvg.1	-	4	794	c.522C>T	c.(520-522)AAC>AAT	p.N174N		NM_178493	NP_848588	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog precursor	174						extracellular region	hydrolase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CCATGTTTGCGTTCCACCAGT	0.602													0	0	0	0.007291	0	24	60										A	79916822	G	A	79916822	2	1	97	1	0	0	0	0	0	0	0	1	10552	1136	40	2		2	NOTUM	17	79916822	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	248742	79916822	1278388	455	29943										
MYL12A	10627	broad.mit.edu	37	chr18	3255845	3255845	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acagagaagcacctattgatAaaaaggggaatttcaattac	8	6	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:3255845A>T	uc002klr.2	+	4	840	c.445A>T	c.(445-447)AAA>TAA	p.K149*	MYL12A_uc002kls.2_Nonsense_Mutation_p.K155*	NM_006471	NP_006462	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory,	149	EF-hand 3.					myosin complex	calcium ion binding|protein binding				0						ACCTATTGATAAAAAGGGGAA	0.433													0	0	0	0.001368	0	13	30										T	3255845	A	T	3255845	4	4	97	1	0	0	0	0	0	1	0	0	10045	363	13	5	455	5	MYL12A	18	3255845	Nonsense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08		3255845	74821403	456	29944										
DLGAP1	9229	broad.mit.edu	37	chr18	3499238	3499238	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cgatgctctcggcgctctcgGtggccgagttctggcggacg	16	13	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:3499238G>A	uc002kmf.2	-	10	2946	c.2879C>T	c.(2878-2880)ACC>ATC	p.T960I	DLGAP1_uc002kme.1_Missense_Mutation_p.T658I|DLGAP1_uc010dkn.2_Missense_Mutation_p.T668I|DLGAP1_uc010wyw.1_Missense_Mutation_p.T666I|DLGAP1_uc010wyx.1_Missense_Mutation_p.T682I|DLGAP1_uc010wyy.1_Missense_Mutation_p.T644I	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	960					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GGCGCTCTCGGTGGCCGAGTT	0.731													0	0	0	0.001368	0	9	21										A	3499238	G	A	3499238	3	1	97	1	0	0	0	0	1	0	0	0	4559	1261	44	2	58	2	DLGAP1	18	3499238	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	243393	3499238	74578010	457	29945										
CEP192	55125	broad.mit.edu	37	chr18	13059227	13059227	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gttgcttcttggccatgttcGacagatgctgagaccatcgt	11	10	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:13059227G>C	uc010xac.1	+	21	4484	c.4404G>C	c.(4402-4404)TCG>TCC	p.S1468S	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.S993S|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_5'UTR|CEP192_uc002krs.1_Silent_p.S1209S	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1468										ovary(4)|pancreas(1)	5						GGCCATGTTCGACAGATGCTG	0.468													0	0	0	0.00361	0	47	112										C	13059227	G	C	13059227	2	2	97	1	0	0	0	0	0	0	0	1	3251	1045	37	1		1	CEP192	18	13059227	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	9559989	13059227	65018021	458	29946										
CEP192	55125	broad.mit.edu	37	chr18	13069784	13069784	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtggatccaaagaatctactCcttaaacctggagaagaaca	8	9	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:13069784C>T	uc010xac.1	+	27	5183	c.5103C>T	c.(5101-5103)CTC>CTT	p.L1701L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.L1226L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Silent_p.L123L|CEP192_uc002krw.2_5'UTR	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1701										ovary(4)|pancreas(1)	5						AGAATCTACTCCTTAAACCTG	0.343													0	0	0	0.001786	0	30	62										T	13069784	C	T	13069784	2	4	97	1	0	0	0	0	0	0	0	1	3251	842	30	1		1	CEP192	18	13069784	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	10557	13069784	65007464	459	29947										
DSG2	1829	broad.mit.edu	37	chr18	29102165	29102165	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctccagtgttctacctaaatAaagatacaggagagatttat	7	7	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:29102165A>C	uc002kwu.3	+	6	831	c.643A>C	c.(643-645)AAA>CAA	p.K215Q		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	215	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CTACCTAAATAAAGATACAGG	0.388													0	0	0	0.00278	0	22	44										C	29102165	A	C	29102165	3	2	97	1	0	0	0	0	1	0	0	0	4777	363	13	5	665	5	DSG2	18	29102165	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	16032381	29102165	48975083	460	29948										
MEP1B	4225	broad.mit.edu	37	chr18	29775413	29775413	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggagaaaagtatagatggcCtcataccattccatatgttc	8	8	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:29775413C>T	uc002kxj.3	+	5	262	c.215C>T	c.(214-216)CCT>CTT	p.P72L		NM_005925	NP_005916	Q16820	MEP1B_HUMAN	meprin A beta precursor	72	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2						TATAGATGGCCTCATACCATT	0.328													0	0	0	0.008871	0	16	39										T	29775413	C	T	29775413	3	4	97	1	0	0	0	0	1	0	0	0	9476	681	24	2	233	2	MEP1B	18	29775413	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	673248	29775413	48301835	461	29949										
KIAA1632	57724	broad.mit.edu	37	chr18	43487976	43487976	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aatatcataatgctttggtaGagaagggatataggtatctc	10	4	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:43487976G>A	uc002lbm.2	-	24	4376	c.4276C>T	c.(4276-4278)CTA>TTA	p.L1426L	KIAA1632_uc002lbo.1_Silent_p.L1426L|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Silent_p.L301L	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1426					autophagy						0						TGCTTTGGTAGAGAAGGGATA	0.308													0	0	0	0.00361	0	47	124										A	43487976	G	A	43487976	2	1	97	1	0	0	0	0	0	0	0	1	8249	933	33	1		1	KIAA1632	18	43487976	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	13712563	43487976	34589272	462	29950										
TCEB3C	162699	broad.mit.edu	37	chr18	44554662	44554662	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agcctgttttcgggttttgtCcgcgggcgccgcgtgccggt	16	12	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:44554662C>T	uc010xdb.1	-	1	1788	c.1552G>A	c.(1552-1554)GAC>AAC	p.D518N	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						CGGGTTTTGTccgcgggcgcc	0.358													0	0	0	0.008871	0	12	449										T	44554662	C	T	44554662	3	4	97	1	0	0	0	0	1	0	0	0	15680	855	30	1	1735	1	TCEB3C	18	44554662	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1066686	44554662	33522586	463	29951										
MBD1	4152	broad.mit.edu	37	chr18	47800609	47800626	+	In_Frame_Del	DEL	TGCCCCCGAATTTGGGCT	TGCCCCCGAATTTGGGCT	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cttctggcgcttctggttgcTgcccccgaatttgggcttgt							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:47800609_47800626delTGCCCCCGAATTTGGGCT	uc010dow.1	-	11	1513_1530	c.1076_1093delAGCCCAAATTCGGGGGCA	c.(1075-1095)AAGCCCAAATTCGGGGGCAGC>AGC	p.KPKFGG359del	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_In_Frame_Del_p.KPKFGG309del|MBD1_uc010xdi.1_In_Frame_Del_p.KPKFGG410del|MBD1_uc002leh.3_Intron|MBD1_uc002len.2_In_Frame_Del_p.KPKFGG359del|MBD1_uc002lei.3_In_Frame_Del_p.KPKFGG359del|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_In_Frame_Del_p.KPKFGG310del|MBD1_uc002lel.3_In_Frame_Del_p.KPKFGG336del|MBD1_uc002lem.3_In_Frame_Del_p.KPKFGG359del|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_In_Frame_Del_p.KPKFGG384del|MBD1_uc010dox.1_In_Frame_Del_p.KPKFGG336del|MBD1_uc002leo.2_In_Frame_Del_p.KPKFGG359del	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	359_364	CXXC-type 3.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTCTGGTTGCTGCCCCCGAATTTGGGCTTGTCGCAGCA	0.651																		24	137	---	---								-	47800626	TGCCCCCGAATTTGGGCT	-	47800609	7	5	97	1	0	1	0	1	0	0	0	0	9342	1580	55	0	942	0	MBD1	18	47800609	In_Frame_Del	DEL	TGCCCCCGAATTTGGGCT	TCGA-G2-A2ES-01A-11D-A17V-08	3245947	47800609	30276639	464	29952										
MAPK4	5596	broad.mit.edu	37	chr18	48190843	48190843	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gattggggatttcgggttggCaaggatcgttgatcagcatt	15	5	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:48190843C>T	uc002lev.2	+	2	1515	c.515C>T	c.(514-516)GCA>GTA	p.A172V	MAPK4_uc010xdm.1_Intron|MAPK4_uc010doz.2_Missense_Mutation_p.A172V	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	172	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		TTCGGGTTGGCAAGGATCGTT	0.532													0	0	0	0.00278	0	24	86										T	48190843	C	T	48190843	3	4	97	1	0	0	0	0	1	0	0	0	9280	710	25	2	517	2	MAPK4	18	48190843	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	390234	48190843	29886405	465	29953										
DSEL	92126	broad.mit.edu	37	chr18	65178545	65178545	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgtatttgctagccacaagtGagacaagagggacactgcat	11	8	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:65178545G>A	uc002lke.1	-	2	4555	c.3331C>T	c.(3331-3333)CAC>TAC	p.H1111Y		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1101						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AGCCACAAGTGAGACAAGAGG	0.388													0	0	0	0.004007	0	16	59										A	65178545	G	A	65178545	3	1	97	1	0	0	0	0	1	0	0	0	4775	1290	45	1	341	1	DSEL	18	65178545	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	16987702	65178545	12898703	466	29954										
ZADH2	284273	broad.mit.edu	37	chr18	72913707	72913707	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagataaaccctattactatCaagcgccctttcgtagccag	7	12	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:72913707C>T	uc002llx.2	-	2	1066	c.798G>A	c.(796-798)TTG>TTA	p.L266L	ZADH2_uc010dqv.2_Silent_p.L143L	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	266						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		CTATTACTATCAAGCGCCCTT	0.507													0	0	0	0.004656	0	26	71										T	72913707	C	T	72913707	2	4	97	1	0	0	0	0	0	0	0	1	17508	825	29	1		1	ZADH2	18	72913707	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	7735162	72913707	5163541	467	29955										
C18orf22	79863	broad.mit.edu	37	chr18	77794534	77794534	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggctgtggcgctcccgcgcGggtctccgggccctgttccg	17	16	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr18:77794534G>T	uc002lns.2	+	1	177	c.39G>T	c.(37-39)GCG>GCT	p.A13A	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Silent_p.A13A|C18orf22_uc010dri.1_RNA	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	13					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GCTCCCGCGCGGGTCTCCGGG	0.706													1	0	1.12685e-05	0.004482	1.37805e-05	9	40										T	77794534	G	T	77794534	2	4	97	1	0	0	0	0	0	0	0	1	1898	1103	39	4		4	C18orf22	18	77794534	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	4880827	77794534	282714	468	29956										
MED16	10025	broad.mit.edu	37	chr19	872058	872058	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gatgaccaccatcaattcccGaagcatgcccagcgaggtgc	10	14	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:872058G>T	uc002lqd.1	-	12	2117	c.1966C>A	c.(1966-1968)CGG>AGG	p.R656R	MED16_uc010drw.1_Intron|MED16_uc002lqe.2_Silent_p.R645R|MED16_uc002lqf.2_Silent_p.R645R	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	656	WD 4.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCAATTCCCGAAGCATGCCC	0.662													1	0	1.52009e-12	0.003163	1.94123e-12	14	52										T	872058	G	T	872058	2	4	97	1	0	0	0	0	0	0	0	1	9434	1057	37	3		3	MED16	19	872058	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		872058	58256925	469	29957										
HMHA1	23526	broad.mit.edu	37	chr19	1073267	1073267	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tggagacgctcaccgcagccGgcaccctcattgccaaggtc	11	16	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:1073267G>T	uc002lqz.1	+	3	772	c.541G>T	c.(541-543)GGC>TGC	p.G181C	HMHA1_uc010xgd.1_Missense_Mutation_p.G197C|HMHA1_uc010xge.1_Missense_Mutation_p.G21C|HMHA1_uc002lra.1_Missense_Mutation_p.G21C|HMHA1_uc002lrb.1_Missense_Mutation_p.G64C	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	181					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCGCAGCCGGCACCCTCAT	0.522													1	0	1.96292e-10	0.001523	2.48637e-10	21	57										T	1073267	G	T	1073267	3	4	97	1	0	0	0	0	1	0	0	0	7240	1116	39	4	551	4	HMHA1	19	1073267	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	201209	1073267	58055716	470	29958										
CIRBP	1153	broad.mit.edu	37	chr19	1270999	1270999	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acaccaatgagcagtcgctgGagcaggtcttctcaaagtac	10	11	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:1270999G>A	uc002lrr.3	+	2	216	c.67G>A	c.(67-69)GAG>AAG	p.E23K	C19orf23_uc010xgk.1_5'Flank|CIRBP_uc010dsg.1_Nonsense_Mutation_p.W5*|CIRBP_uc002lrt.2_Missense_Mutation_p.E23K|CIRBP_uc010xgl.1_Missense_Mutation_p.E23K|CIRBP_uc002lrv.3_Missense_Mutation_p.E23K|CIRBP_uc002lru.2_RNA	NM_001280	NP_001271	Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	23	RRM.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGTCGCTGGAGCAGGTCTT	0.388													0	0	0	0.00361	0	72	180										A	1270999	G	A	1270999	3	1	97	1	0	0	0	0	1	0	0	0	3433	1175	41	1	69	1	CIRBP	19	1270999	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	197732	1270999	57857984	471	29959										
CREB3L3	84699	broad.mit.edu	37	chr19	4159761	4159761	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtgaaagacctcctcctttcGggcagcagtggggacctggt	14	11	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:4159761G>A	uc002lzl.2	+	4	674	c.558G>A	c.(556-558)TCG>TCA	p.S186S	CREB3L3_uc002lzm.2_Silent_p.S176S|CREB3L3_uc010xib.1_Silent_p.S177S|CREB3L3_uc010xic.1_Silent_p.S177S	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	186	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCCTTTCGGGCAGCAGTG	0.428													0	0	0	0.002096	0	29	74										A	4159761	G	A	4159761	2	1	97	1	0	0	0	0	0	0	0	1	3858	1103	39	2		2	CREB3L3	19	4159761	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2888762	4159761	54969222	472	29960										
UBXN6	80700	broad.mit.edu	37	chr19	4453498	4453499	+	Missense_Mutation	DNP	TC	TC	GT													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggctcccgctgacggtggctTcggcttgaagttcctttctc							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:4453498_4453499TC>GT	uc002man.1	-	3	364_365	c.268_269GA>AC	c.(268-270)GAA>ACA	p.E90T	UBXN6_uc010dty.1_Missense_Mutation_p.E37T|UBXN6_uc002mam.1_Missense_Mutation_p.E37T	NM_025241	NP_079517	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	90						microtubule organizing center|nucleus	protein binding				0						GACGGTGGCTTCGGCTTGAAGT	0.629													0	0	0	0.004672	0	12	33										GT	4453499	TC	GT	4453498	3	3	97	1	0	0	0	0	1	0	0	0	16914	1783	62	5	1092	5	UBXN6	19	4453498	Missense_Mutation	DNP	TC	TCGA-G2-A2ES-01A-11D-A17V-08	293737	4453498	54675485	473	29961										
KIAA1543	57662	broad.mit.edu	37	chr19	7676817	7676817	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcctcccagatggggcggccGacggcagcttctacctccac	11	17	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:7676817G>A	uc002mgv.3	+	11	1539	c.1438G>A	c.(1438-1440)GAC>AAC	p.D480N	KIAA1543_uc002mgu.3_Missense_Mutation_p.D507N|KIAA1543_uc002mgw.2_5'Flank	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	480	Pro-rich.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						TGGGGCGGCCGACGGCAGCTT	0.692													0	0	0	0.007413	0	17	48										A	7676817	G	A	7676817	3	1	97	1	0	0	0	0	1	0	0	0	8243	1058	37	1	1569	1	KIAA1543	19	7676817	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3223319	7676817	51452166	474	29962										
MUC16	94025	broad.mit.edu	37	chr19	9064866	9064866	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	actgaattttcctagtgttaGataaggcaggagttaatgta	10	4	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:9064866G>T	uc002mkp.2	-	3	22784	c.22580C>A	c.(22579-22581)TCT>TAT	p.S7527Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7529	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTAGTGTTAGATAAGGCAGG	0.483													1	0	2.65835e-16	0.007291	3.44568e-16	29	66										T	9064866	G	T	9064866	3	4	97	1	0	0	0	0	1	0	0	0	9973	942	33	3	21271	3	MUC16	19	9064866	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1388049	9064866	50064117	475	29963										
OR7G2	390882	broad.mit.edu	37	chr19	9213259	9213259	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tctcaaaacacaggaggtgaTctgagtgtaagacaaaatga	10	6	2	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:9213259T>C	uc010xkk.1	-	1	724	c.724A>G	c.(724-726)ATC>GTC	p.I242V		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CAGGAGGTGATCTGAGTGTAA	0.448													0	0	0	0.007291	0	30	93										C	9213259	T	C	9213259	3	2	97	1	0	0	0	0	1	0	0	0	11223	1435	50	5	315	5	OR7G2	19	9213259	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	148393	9213259	49915724	476	29964										
SMARCA4	6597	broad.mit.edu	37	chr19	11094925	11094925	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	catgctgggccctagcccggGtccctcgccgggctccgccc	13	20	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:11094925G>A	uc002mqf.3	+	2	382	c.98G>A	c.(97-99)GGT>GAT	p.G33D	SMARCA4_uc010dxp.2_Missense_Mutation_p.G33D|SMARCA4_uc010dxo.2_Missense_Mutation_p.G33D|SMARCA4_uc002mqg.1_Missense_Mutation_p.G33D|SMARCA4_uc010dxq.2_Missense_Mutation_p.G33D|SMARCA4_uc010dxr.2_Missense_Mutation_p.G33D|SMARCA4_uc002mqj.3_Missense_Mutation_p.G33D|SMARCA4_uc010dxs.2_Missense_Mutation_p.G33D|SMARCA4_uc002mqe.2_Missense_Mutation_p.G33D	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	33	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCTAGCCCGGGTCCCTCGCCG	0.726			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.006214	0	10	46										A	11094925	G	A	11094925	3	1	97	1	0	0	0	0	1	0	0	0	14770	1261	44	2	100	2	SMARCA4	19	11094925	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1881666	11094925	48034058	477	29965										
NANOS3	342977	broad.mit.edu	37	chr19	13988429	13988429	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcgccacacgtgagcgcgccCacacccgacgcttctgccca	10	20	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:13988429C>T	uc002mxj.3	+	1	480	c.367C>T	c.(367-369)CAC>TAC	p.H123Y		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	104	C2HC 2.|Nanos-type.				anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGAGCGCGCCCACACCCGACG	0.652													0	0	0	0.000978	0	12	22										T	13988429	C	T	13988429	3	4	97	1	0	0	0	0	1	0	0	0	10153	594	21	2	369	2	NANOS3	19	13988429	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2893504	13988429	45140554	478	29966										
AKAP8	10270	broad.mit.edu	37	chr19	15466028	15466028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gctctctggagcgggcgctcCttccccatctacggccctca	10	18	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:15466028C>T	uc002nav.2	-	14	1838	c.1777G>A	c.(1777-1779)GGA>AGA	p.G593R	AKAP8_uc010dzy.2_Missense_Mutation_p.G142R	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	593					signal transduction	nuclear matrix				ovary(1)|breast(1)	2						GCGGGCGCTCCTTCCCCATCT	0.617													0	0	0	0.00874	0	39	92										T	15466028	C	T	15466028	3	4	97	1	0	0	0	0	1	0	0	0	457	690	24	2	305	2	AKAP8	19	15466028	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1477599	15466028	43662955	479	29967										
MAP1S	55201	broad.mit.edu	37	chr19	17837423	17837423	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggcgccgagcgcacgctggcCtctgtgtgcgccctgctggt	16	15	1	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:17837423C>T	uc002nhe.1	+	5	1239	c.1230C>T	c.(1228-1230)GCC>GCT	p.A410A	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Silent_p.A410A|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Silent_p.A384A	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	410	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GCACGCTGGCCTCTGTGTGCG	0.726													0	0	0	0.000248	0	4	7										T	17837423	C	T	17837423	2	4	97	1	0	0	0	0	0	0	0	1	9234	668	24	2		2	MAP1S	19	17837423	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	2371395	17837423	41291560	480	29968										
UPF1	5976	broad.mit.edu	37	chr19	18965703	18965703	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cacaggatgcagagcgcattGaaaacgtttgccgtggatga	13	8	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:18965703G>A	uc002nkg.2	+	10	1589	c.1314G>A	c.(1312-1314)TTG>TTA	p.L438L	UPF1_uc002nkf.2_Silent_p.L427L	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	438					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGAGCGCATTGAAAACGTTTG	0.587													0	0	0	0.00499	0	16	37										A	18965703	G	A	18965703	2	1	97	1	0	0	0	0	0	0	0	1	17000	1281	45	1		1	UPF1	19	18965703	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1128280	18965703	40163280	481	29969										
ZNF101	94039	broad.mit.edu	37	chr19	19790184	19790184	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agctcatgctggacacaaacGatctgagtgtggtggggaat	14	7	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:19790184G>T	uc002nni.1	+	4	496	c.386G>T	c.(385-387)CGA>CTA	p.R129L	ZNF101_uc010ecg.1_Missense_Mutation_p.R9L|ZNF101_uc002nnj.1_Missense_Mutation_p.R9L	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGACACAAACGATCTGAGTGT	0.522													1	0	1.5548e-18	0.005443	2.03561e-18	28	62										T	19790184	G	T	19790184	3	4	97	1	0	0	0	0	1	0	0	0	17711	1058	37	3	400	3	ZNF101	19	19790184	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	824481	19790184	39338799	482	29970										
ZNF708	7562	broad.mit.edu	37	chr19	21493399	21493399	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccactcctccagagagaattCtatggccacatccataaatg	6	13	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:21493399C>T	uc002npq.1	-	2	232	c.34G>A	c.(34-36)GAA>AAA	p.E12K	ZNF708_uc002npr.1_Intron|ZNF708_uc010ecs.1_Intron	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	12	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						AGAGAGAATTCTATGGCCACA	0.398													0	0	0	0.002836	0	33	109										T	21493399	C	T	21493399	3	4	97	1	0	0	0	0	1	0	0	0	18109	922	32	1	1669	1	ZNF708	19	21493399	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1703215	21493399	37635584	483	29971										
PDCD5	9141	broad.mit.edu	37	chr19	33072194	33072194	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gacgaggagcttgaggcgctGaggagacagaggctggccga	19	8	0	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:33072194G>A	uc002ntm.2	+	1	91	c.27G>A	c.(25-27)CTG>CTA	p.L9L	PDCD5_uc002ntl.2_Silent_p.L9L|PDCD5_uc010ede.2_RNA	NM_004708	NP_004699	O14737	PDCD5_HUMAN	programmed cell death 5	9					apoptosis|induction of apoptosis	cytoplasm|nucleus	DNA binding			ovary(1)|lung(1)	2	Esophageal squamous(110;0.137)					TTGAGGCGCTGAGGAGACAGA	0.736													0	0	0	0.004482	0	7	11										A	33072194	G	A	33072194	2	1	97	1	0	0	0	0	0	0	0	1	11622	1277	45	1		1	PDCD5	19	33072194	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	11578795	33072194	26056789	484	29972										
ANKRD27	84079	broad.mit.edu	37	chr19	33106574	33106574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaagccaaaccttctgagctGgggcacacttggggcactgg	13	11	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:33106574G>A	uc002ntn.1	-	22	2321	c.2165C>T	c.(2164-2166)CCA>CTA	p.P722L		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	722					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					CTTCTGAGCTGGGGCACACTT	0.438													0	0	0	0.008361	0	25	89										A	33106574	G	A	33106574	3	1	97	1	0	0	0	0	1	0	0	0	655	1348	47	2	1019	2	ANKRD27	19	33106574	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	34380	33106574	26022409	485	29973										
UBA2	10054	broad.mit.edu	37	chr19	34919421	34919421	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtggtgggggcgggcggcatCggctgcgagctcctcaagaa	19	10	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:34919421C>T	uc002nvk.2	+	1	154	c.84C>T	c.(82-84)ATC>ATT	p.I28I	UBA2_uc010xrx.1_5'UTR|UBA2_uc002nvl.2_5'Flank	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	28	ATP.				protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGGGCGGCATCGGCTGCGAGC	0.736													0	0	0	0.00245	0	12	29										T	34919421	C	T	34919421	2	4	97	1	0	0	0	0	0	0	0	1	16825	874	31	1		1	UBA2	19	34919421	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1812847	34919421	24209562	486	29974										
LSR	51599	broad.mit.edu	37	chr19	35758181	35758181	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcaggcgggggctggcgggcCaggcggccccgggcccgctc	21	16	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:35758181C>T	uc002nyl.2	+	9	1681	c.1458C>T	c.(1456-1458)GCC>GCT	p.A486A	LSR_uc002nym.2_Silent_p.A467A|LSR_uc002nyn.2_Silent_p.A418A|LSR_uc002nyo.2_Silent_p.A466A|LSR_uc010xsr.1_Silent_p.A378A|LSR_uc002nyp.2_Silent_p.A428A|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	486	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			gctggcgggccaggcggcccc	0.577													0	0	0	0.004672	0	3	6										T	35758181	C	T	35758181	2	4	97	1	0	0	0	0	0	0	0	1	9064	581	21	2		2	LSR	19	35758181	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	838760	35758181	23370802	487	29975										
CD22	933	broad.mit.edu	37	chr19	35823632	35823632	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agaacacctcgaagtttgatGggacaagactctatgaaagc	10	8	1	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:35823632G>A	uc010edt.2	+	3	294	c.217G>A	c.(217-219)GGG>AGG	p.G73R	CD22_uc010xst.1_5'UTR|CD22_uc010edu.2_Missense_Mutation_p.G73R|CD22_uc010edv.2_Missense_Mutation_p.G73R|CD22_uc002nzb.3_Missense_Mutation_p.G73R	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	73	Extracellular (Potential).|Ig-like V-type.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	GAAGTTTGATGGGACAAGACT	0.473													0	0	0	0.00623	0	39	99										A	35823632	G	A	35823632	3	1	97	1	0	0	0	0	1	0	0	0	2985	1348	47	2	223	2	CD22	19	35823632	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	65451	35823632	23305351	488	29976										
LGALS4	3960	broad.mit.edu	37	chr19	39292541	39292541	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaagcgatccaagccacagcGaatggacagctgcagggaga	14	10	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:39292541G>C	uc002ojg.2	-	10	1049	c.835C>G	c.(835-837)CGC>GGC	p.R279G		NM_006149	NP_006140	P56470	LEG4_HUMAN	galectin-4	279	Galectin 2.				cell adhesion	cytosol|plasma membrane	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;1.02e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			AAGCCACAGCGAATGGACAGC	0.562													0	0	0	0.00361	0	47	113										C	39292541	G	C	39292541	3	2	97	1	0	0	0	0	1	0	0	0	8745	1058	37	1	140	1	LGALS4	19	39292541	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3468909	39292541	19836442	489	29977										
EID2	163126	broad.mit.edu	37	chr19	40030040	40030040	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgataaacttatcgcaaccaAgttcttctatcagagggttg	8	8	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:40030040A>C	uc002oma.2	-	1	799	c.680T>G	c.(679-681)CTT>CGT	p.L227R		NM_153232	NP_694964	Q8N6I1	EID2_HUMAN	CREBBP/EP300 inhibitor 2	227					cell differentiation|muscle organ development|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|SMAD protein complex assembly|transcription, DNA-dependent|transforming growth factor beta receptor complex assembly	nucleus	SMAD binding				0	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;3.2e-25)|all cancers(26;8.83e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			ATCGCAACCAAGTTCTTCTAT	0.413													0	0	0	0.004656	0	25	80										C	40030040	A	C	40030040	3	2	97	1	0	0	0	0	1	0	0	0	4987	72	3	5	34	5	EID2	19	40030040	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	737499	40030040	19098943	490	29978										
PRX	57716	broad.mit.edu	37	chr19	40901699	40901699	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gtctagctccactgaaggcaGagtgagagaggggacaccca	14	10	1	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:40901699G>A	uc002onr.2	-	7	2829	c.2560C>T	c.(2560-2562)CTG>TTG	p.L854L	PRX_uc002onq.2_Silent_p.L715L|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	854					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTGAAGGCAGAGTGAGAGAG	0.632													0	0	0	0.004656	0	26	90										A	40901699	G	A	40901699	2	1	97	1	0	0	0	0	0	0	0	1	12642	933	33	1		1	PRX	19	40901699	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	871659	40901699	18227284	491	29979										
CIC	23152	broad.mit.edu	37	chr19	42797418	42797418	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaggagcggaccagcgccaaGggccctgagaccatggtgag	17	11	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:42797418G>A	uc002otf.1	+	15	3820	c.3780G>A	c.(3778-3780)AAG>AAA	p.K1260K		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	1260	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CCAGCGCCAAGGGCCCTGAGA	0.667			T	DUX4	soft tissue sarcoma								0	0	0	0.004672	0	3	9										A	42797418	G	A	42797418	2	1	97	1	0	0	0	0	0	0	0	1	3424	991	35	2		2	CIC	19	42797418	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1895719	42797418	16331565	492	29980										
ZNF225	7768	broad.mit.edu	37	chr19	44635316	44635316	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acatgtgatgaatgtggaaaGagtttctgttatagctcagc	11	5	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:44635316G>C	uc002oyj.1	+	5	792	c.549G>C	c.(547-549)AAG>AAC	p.K183N	ZNF225_uc010eje.1_Missense_Mutation_p.K100N|ZNF225_uc010ejf.1_Missense_Mutation_p.K183N	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	183	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AATGTGGAAAGAGTTTCTGTT	0.403													0	0	0	0.00278	0	25	91										C	44635316	G	C	44635316	3	2	97	1	0	0	0	0	1	0	0	0	17776	933	33	1	563	1	ZNF225	19	44635316	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1837898	44635316	14493667	493	29981										
ZNF180	7733	broad.mit.edu	37	chr19	44980836	44980836	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tatgagttctctgatgttgaGtaaggcatgaactctgtctg	11	6	3	4			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:44980836G>C	uc002ozf.3	-	5	2144	c.1862C>G	c.(1861-1863)ACT>AGT	p.T621S	ZNF180_uc002ozh.3_Missense_Mutation_p.T278S|ZNF180_uc002ozi.3_Missense_Mutation_p.T594S|ZNF180_uc002ozg.3_Missense_Mutation_p.T620S|ZNF180_uc010ejm.2_Missense_Mutation_p.T596S	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	621	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				CTGATGTTGAGTAAGGCATGA	0.398													0	0	0	0.006999	0	43	89										C	44980836	G	C	44980836	3	2	97	1	0	0	0	0	1	0	0	0	17745	1029	36	4	220	4	ZNF180	19	44980836	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	345520	44980836	14148147	494	29982										
ERCC2	2068	broad.mit.edu	37	chr19	45871992	45871992	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gttgagcaactttcgaagctCttcaatcacctactccaaag	6	12	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:45871992C>G	uc002pbj.2	-	5	303	c.256G>C	c.(256-258)GAG>CAG	p.E86Q	ERCC2_uc010ejz.2_Missense_Mutation_p.E86Q|ERCC2_uc002pbk.2_Missense_Mutation_p.E62Q|ERCC2_uc002pbl.3_Missense_Mutation_p.E62Q|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	86	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TTTCGAAGCTCTTCAATCACC	0.562			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001984	0	7	26										G	45871992	C	G	45871992	3	3	97	1	0	0	0	0	1	0	0	0	5213	922	32	1	2159	1	ERCC2	19	45871992	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	891156	45871992	13256991	495	29983										
IGFL4	444882	broad.mit.edu	37	chr19	46543538	46543538	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcagtgctggaagcagggCcagaaggtgcagctggagcc	17	10	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:46543538C>A	uc002pdy.1	-	3	261	c.207G>T	c.(205-207)TGG>TGT	p.W69C		NM_001002923	NP_001002923	Q6B9Z1	IGFL4_HUMAN	IGF-like family member 4 precursor	69						extracellular region					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		GGAAGCAGGGCCAGAAGGTGC	0.592													1	0	3.7963e-18	0.00333	4.96195e-18	26	57										A	46543538	C	A	46543538	3	1	97	1	0	0	0	0	1	0	0	0	7589	740	26	4	175	4	IGFL4	19	46543538	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	671546	46543538	12585445	496	29984										
DHX34	9704	broad.mit.edu	37	chr19	47865850	47865850	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggcgggccgcacgggccccgGagtctgcttccgcctctatg	15	16	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:47865850G>C	uc010xyn.1	+	6	1834	c.1493G>C	c.(1492-1494)GGA>GCA	p.G498A	DHX34_uc010elc.1_Missense_Mutation_p.G413A	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	498	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		ACGGGCCCCGGAGTCTGCTTC	0.657													0	0	0	0.001855	0	12	27										C	47865850	G	C	47865850	3	2	97	1	0	0	0	0	1	0	0	0	4507	1174	41	1	1511	1	DHX34	19	47865850	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1322312	47865850	11263133	497	29985										
PPFIA3	8541	broad.mit.edu	37	chr19	49652416	49652416	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcctgcagatccccacgcaGaatgcacaggtgagctgccg	11	15	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:49652416G>A	uc002pmr.2	+	26	3608	c.3276G>A	c.(3274-3276)CAG>CAA	p.Q1092Q	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Silent_p.Q951Q|PPFIA3_uc002pmt.2_Silent_p.Q231Q|PPFIA3_uc002pmu.1_Silent_p.Q141Q	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	1092	SAM 3.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TCCCCACGCAGAATGCACAGG	0.677													0	0	0	0.006122	0	16	38										A	49652416	G	A	49652416	2	1	97	1	0	0	0	0	0	0	0	1	12311	933	33	1		1	PPFIA3	19	49652416	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	1786566	49652416	9476567	498	29986										
RCN3	57333	broad.mit.edu	37	chr19	50031853	50031853	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accaggcggcccccctgagcGacgctccccatgatgacgcc	11	19	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:50031853G>A	uc002poj.2	+	2	571	c.124G>A	c.(124-126)GAC>AAC	p.D42N		NM_020650	NP_065701	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	42						endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		CCCCCTGAGCGACGCTCCCCA	0.652													0	0	0	0.00874	0	41	111										A	50031853	G	A	50031853	3	1	97	1	0	0	0	0	1	0	0	0	13181	1058	37	1	126	1	RCN3	19	50031853	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	379437	50031853	9097130	499	29987										
PNKP	11284	broad.mit.edu	37	chr19	50365522	50365522	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cggggaggcagagaggccctGagcgggagacagtcctctgc	18	11	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:50365522G>A	uc002pqh.2	-	11	1098	c.1046C>T	c.(1045-1047)TCA>TTA	p.S349L	PNKP_uc002pqg.2_Missense_Mutation_p.S130L|PNKP_uc002pqi.2_Missense_Mutation_p.S310L|PNKP_uc002pqj.2_Missense_Mutation_p.S349L|PNKP_uc010enm.2_Missense_Mutation_p.S318L|PNKP_uc002pqk.2_Missense_Mutation_p.S349L	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	349					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GAGAGGCCCTGAGCGGGAGAC	0.607								Other_BER_factors					0	0	0	0.00308	0	7	19										A	50365522	G	A	50365522	3	1	97	1	0	0	0	0	1	0	0	0	12147	1294	45	1	543	1	PNKP	19	50365522	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	333669	50365522	8763461	500	29988										
SHANK1	50944	broad.mit.edu	37	chr19	51169762	51169762	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caccggtgggacttctggctCtacagccaccggaccccccg	11	18	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:51169762C>G	uc002psx.1	-	22	5474	c.5455G>C	c.(5455-5457)GAG>CAG	p.E1819Q	SHANK1_uc002psw.1_Missense_Mutation_p.E1203Q	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1819					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACTTCTGGCTCTACAGCCACC	0.726													0	0	0	0.001984	0	7	14										G	51169762	C	G	51169762	3	3	97	1	0	0	0	0	1	0	0	0	14264	922	32	1	1038	1	SHANK1	19	51169762	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	804240	51169762	7959221	501	29989										
LENG9	94059	broad.mit.edu	37	chr19	54974069	54974069	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgcccagcgccctctcctggGccgcctccagctctccgggt	11	20	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:54974069G>A	uc010yez.1	-	1	826	c.707C>T	c.(706-708)GCC>GTC	p.A236V		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	236					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		CCTCTCCTGGGCCGCCTCCAG	0.682													0	0	0	0.001786	0	30	52										A	54974069	G	A	54974069	3	1	97	1	0	0	0	0	1	0	0	0	8725	1203	42	2	802	2	LENG9	19	54974069	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	3804307	54974069	4154914	502	29990										
EPS8L1	54869	broad.mit.edu	37	chr19	55593171	55593171	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accacgtgttcgacgacgtaGagagctttgtatcgaggctg	13	9	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:55593171G>C	uc002qis.3	+	9	909	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	EPS8L1_uc010ess.1_Missense_Mutation_p.E251Q|EPS8L1_uc010est.1_Missense_Mutation_p.E269Q|EPS8L1_uc010yfr.1_Missense_Mutation_p.E205Q|EPS8L1_uc010esu.1_RNA|EPS8L1_uc002qiu.2_Missense_Mutation_p.E142Q|EPS8L1_uc002qiv.2_5'UTR|EPS8L1_uc002qiw.2_5'Flank	NM_133180	NP_573441	Q8TE68	ES8L1_HUMAN	epidermal growth factor receptor pathway	269						cytoplasm					0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CGACGACGTAGAGAGCTTTGT	0.667													0	0	0	0.008871	0	19	48										C	55593171	G	C	55593171	3	2	97	1	0	0	0	0	1	0	0	0	5195	943	33	1	887	1	EPS8L1	19	55593171	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	619102	55593171	3535812	503	29991										
NLRP4	147945	broad.mit.edu	37	chr19	56388434	56388434	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ctcatcagcaatcaaaacctGaagattctgcaaattgggtg	8	9	4	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:56388434G>A	uc002qmd.3	+	8	3020	c.2598G>A	c.(2596-2598)CTG>CTA	p.L866L	NLRP4_uc002qmf.2_Silent_p.L791L|NLRP4_uc010etf.2_Silent_p.L641L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	866	LRR 6.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATCAAAACCTGAAGATTCTGC	0.478													0	0	0	0.00361	0	58	172										A	56388434	G	A	56388434	2	1	97	1	0	0	0	0	0	0	0	1	10479	1277	45	1		1	NLRP4	19	56388434	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	795263	56388434	2740549	504	29992										
ZNF583	147949	broad.mit.edu	37	chr19	56935524	56935524	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaatgtaatgtttgtgggaaAgcatttagctatagtggatc	12	3	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:56935524A>T	uc010ygl.1	+	5	1662	c.1497A>T	c.(1495-1497)AAA>AAT	p.K499N	ZNF583_uc002qnc.2_Missense_Mutation_p.K499N|ZNF583_uc010ygm.1_Missense_Mutation_p.K499N	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	499	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TTTGTGGGAAAGCATTTAGCT	0.393													0	0	0	0.006999	0	41	95										T	56935524	A	T	56935524	3	4	97	1	0	0	0	0	1	0	0	0	18012	69	3	5	1511	5	ZNF583	19	56935524	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	547090	56935524	2193459	505	29993										
ZNF264	9422	broad.mit.edu	37	chr19	57716855	57716855	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agacctctcccaagacacctGtccaggtaggagccaagatc	9	14	1	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr19:57716855G>A	uc002qob.2	+	3	664	c.251G>A	c.(250-252)TGT>TAT	p.C84Y		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	84	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CAAGACACCTGTCCAGGTAGG	0.552													0	0	0	0.00308	0	7	27										A	57716855	G	A	57716855	3	1	97	1	0	0	0	0	1	0	0	0	17801	1377	48	2	261	2	ZNF264	19	57716855	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	781331	57716855	1412128	506	29994										
ZCCHC3	85364	broad.mit.edu	37	chr20	279103	279103	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	aaagtgaccgacaggtttggGatctggaccggggagtacaa	15	7	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:279103G>T	uc002wdf.2	+	2	897	c.873G>T	c.(871-873)GGG>GGT	p.G291G	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	292							nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			ACAGGTTTGGGATCTGGACCG	0.647													1	0	2.48696e-23	0.003271	3.31169e-23	34	106										T	279103	G	T	279103	2	4	97	1	0	0	0	0	0	0	0	1	17586	1161	41	3		3	ZCCHC3	20	279103	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		279103	62746417	507	29995										
TBC1D20	128637	broad.mit.edu	37	chr20	419827	419827	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaacaaaaaggtctcctgctCtgctgatcagtgtctcatag	9	10	4	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:419827C>T	uc002wds.2	-	7	1019	c.881G>A	c.(880-882)AGA>AAA	p.R294K	TBC1D20_uc002wdv.2_Missense_Mutation_p.R117K|TBC1D20_uc002wdt.2_RNA|TBC1D20_uc002wdu.2_RNA	NM_144628	NP_653229	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	294					interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)	1		all_epithelial(17;0.228)|Breast(17;0.231)				GTCTCCTGCTCTGCTGATCAG	0.582													0	0	0	0.000978	0	12	43										T	419827	C	T	419827	3	4	97	1	0	0	0	0	1	0	0	0	15606	913	32	1	338	1	TBC1D20	20	419827	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	140724	419827	62605693	508	29996										
SNPH	9751	broad.mit.edu	37	chr20	1286301	1286301	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agggcccagagaccccaactCagcagtggtggtgacagtgg	15	11	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:1286301C>G	uc002wes.2	+	6	1324	c.1088C>G	c.(1087-1089)TCA>TGA	p.S363*	SNPH_uc002wet.2_Nonsense_Mutation_p.S407*	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	363					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						GACCCCAACTCAGCAGTGGTG	0.657													0	0	0	0.007413	0	20	71										G	1286301	C	G	1286301	4	3	97	1	0	0	0	0	0	1	0	0	14850	838	29	1	1102	1	SNPH	20	1286301	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	866474	1286301	61739219	509	29997										
TGM6	343641	broad.mit.edu	37	chr20	2413168	2413168	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ggagcctcaggagagggcctCagtccagtttgacatcaccc	12	13	3	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:2413168C>A	uc002wfy.1	+	13	2061	c.2000C>A	c.(1999-2001)TCA>TAA	p.S667*	TGM6_uc010gal.1_Silent_p.L622L	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	667					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GAGAGGGCCTCAGTCCAGTTT	0.587													1	0	1.36615e-20	0.002836	1.80378e-20	34	95										A	2413168	C	A	2413168	4	1	97	1	0	0	0	0	0	1	0	0	15831	838	29	3	2050	3	TGM6	20	2413168	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1126867	2413168	60612352	510	29998										
OXT	5020	broad.mit.edu	37	chr20	3052881	3052881	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tccggccagaaggcgtgcggGagcgggggccgctgcgcggt	21	12	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:3052881G>A	uc002wht.1	+	2	315	c.279G>A	c.(277-279)GGG>GGA	p.G93G		NM_000915	NP_000906	P01178	NEU1_HUMAN	oxytocin-neurophysin I preproprotein	93					signal transduction		neurohypophyseal hormone activity				0					Oxytocin(DB00107)	AGGCGTGCGGGAGCGGGGGCC	0.766													0	0	0	0.001855	0	13	28										A	3052881	G	A	3052881	2	1	97	1	0	0	0	0	0	0	0	1	11337	1161	41	1		1	OXT	20	3052881	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	639713	3052881	59972639	511	29999										
CENPB	1059	broad.mit.edu	37	chr20	3766484	3766484	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gggtggcttgacgcggccgtCcgtcgcctccgcacagcccc	14	18	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:3766484C>T	uc002wjk.2	-	1	854	c.647G>A	c.(646-648)GGA>GAA	p.G216E	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	216					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						ACGCGGCCGTCCGTCGCCTCC	0.706													0	0	0	0.003755	0	32	116										T	3766484	C	T	3766484	3	4	97	1	0	0	0	0	1	0	0	0	3227	855	30	1	1156	1	CENPB	20	3766484	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	713603	3766484	59259036	512	30000										
JAG1	182	broad.mit.edu	37	chr20	10639244	10639244	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agccaaagccatagtagtagTcatcacaggtcacgcggatc	10	11	3	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:10639244T>A	uc002wnw.2	-	4	1082	c.566A>T	c.(565-567)GAC>GTC	p.D189V		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	189	Extracellular (Potential).|DSL.				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						ATAGTAGTAGTCATCACAGGT	0.527									Alagille_Syndrome				0	0	0	0.005524	0	37	95										A	10639244	T	A	10639244	3	1	97	1	0	0	0	0	1	0	0	0	7934	1667	58	5	3182	5	JAG1	20	10639244	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08	6872760	10639244	52386276	513	30001										
C20orf160	140706	broad.mit.edu	37	chr20	30602794	30602794	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcgtgagccgccggcccctgCactcgatgcccctttatccc	10	19	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:30602794C>T	uc002wxf.2	+	2	131	c.118C>T	c.(118-120)CAC>TAC	p.H40Y		NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	40										central_nervous_system(3)|ovary(1)	4						CCGGCCCCTGCACTCGATGCC	0.637													0	0	0	0.00361	0	58	133										T	30602794	C	T	30602794	3	4	97	1	0	0	0	0	1	0	0	0	2093	710	25	2	124	2	C20orf160	20	30602794	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	19963550	30602794	32422726	514	30002										
KIF3B	9371	broad.mit.edu	37	chr20	30898454	30898483	+	In_Frame_Del	DEL	TATCGGGACTCAAAGCTTACCAGGCTCCTC	TATCGGGACTCAAAGCTTACCAGGCTCCTC	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcaaaagcactcacattccaTatcgggactcaaagcttacc							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:30898454_30898483delTATCGGGACTCAAAGCTTACCAGGCTCCTC	uc002wxq.2	+	2	1041_1070	c.874_903delTATCGGGACTCAAAGCTTACCAGGCTCCTC	c.(874-903)TATCGGGACTCAAAGCTTACCAGGCTCCTCdel	p.YRDSKLTRLL292del	KIF3B_uc010ztv.1_In_Frame_Del_p.YRDSKLTRLL292del|KIF3B_uc010ztw.1_In_Frame_Del_p.YRDSKLTRLL292del	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	292_301	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCACATTCCATATCGGGACTCAAAGCTTACCAGGCTCCTCCAAGATTCCC	0.509																		8	62	---	---								-	30898483	TATCGGGACTCAAAGCTTACCAGGCTCCTC	-	30898454	7	5	97	1	0	1	0	1	0	0	0	0	8301	1406	49	0	876	0	KIF3B	20	30898454	In_Frame_Del	DEL	TATCGGGACTCAAAGCTTACCAGGCTCCTC	TCGA-G2-A2ES-01A-11D-A17V-08	295660	30898454	32127066	515	30003										
ITCH	83737	broad.mit.edu	37	chr20	33057885	33057897	+	Frame_Shift_Del	DEL	ACTTCAAAGCAAA	ACTTCAAAGCAAA	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tcagatagcctatgttcgggActtcaaagcaaaggttcagt							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:33057885_33057897delACTTCAAAGCAAA	uc010geu.1	+	16	1772_1784	c.1580_1592delACTTCAAAGCAAA	c.(1579-1593)GACTTCAAAGCAAAGfs	p.D527fs	ITCH_uc002xak.2_Frame_Shift_Del_p.D486fs|ITCH_uc010zuj.1_Frame_Shift_Del_p.D376fs	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	527_531					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TATGTTCGGGACTTCAAAGCAAAGGTTCAGTAT	0.399																		49	308	---	---								-	33057897	ACTTCAAAGCAAA	-	33057885	7	5	97	1	0	1	0	1	0	0	0	0	7868	275	10	0	1507	0	ITCH	20	33057885	Frame_Shift_Del	DEL	ACTTCAAAGCAAA	TCGA-G2-A2ES-01A-11D-A17V-08	2159431	33057885	29967635	516	30004										
SLC2A10	81031	broad.mit.edu	37	chr20	45355551	45355551	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccctgtggagatacgaggaaGagccttcgccttctgcaaca	11	12	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:45355551G>A	uc002xsl.2	+	3	1434	c.1337G>A	c.(1336-1338)AGA>AAA	p.R446K		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	446	Helical; Name=11; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				ATACGAGGAAGAGCCTTCGCC	0.562													0	0	0	0.003214	0	48	137										A	45355551	G	A	45355551	3	1	97	1	0	0	0	0	1	0	0	0	14539	942	33	1	1347	1	SLC2A10	20	45355551	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	12297666	45355551	17669969	517	30005										
GNAS	2778	broad.mit.edu	37	chr20	57485061	57485061	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	acaagcaagatctgctcgctGagaaagtccttgctgggaaa	11	9	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:57485061G>A	uc002xzw.2	+	11	3109	c.2824G>A	c.(2824-2826)GAG>AAG	p.E942K	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.E240K|GNAS_uc002xzx.2_Missense_Mutation_p.E240K|GNAS_uc010gjr.2_Missense_Mutation_p.E190K|GNAS_uc002xzy.2_Missense_Mutation_p.E225K|GNAS_uc002yaa.2_Missense_Mutation_p.E285K|GNAS_uc010zzt.1_Missense_Mutation_p.E300K|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.E190K|GNAS_uc002yae.2_Missense_Mutation_p.E224K	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	299					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TCTGCTCGCTGAGAAAGTCCT	0.507			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	0.00361	0	67	162										A	57485061	G	A	57485061	3	1	97	1	0	0	0	0	1	0	0	0	6510	1291	45	1	3754	1	GNAS	20	57485061	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	12129510	57485061	5540459	518	30006										
C20orf195	79025	broad.mit.edu	37	chr20	62187700	62187708	+	In_Frame_Del	DEL	GTTCGTCAC	GTTCGTCAC	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gactgggcccggctgcgctgGttcgtcaccatccagccagc					rs150942473	by1000genomes	TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:62187700_62187708delGTTCGTCAC	uc002yfj.2	+	2	776_784	c.684_692delGTTCGTCAC	c.(682-693)TGGTTCGTCACC>TGC	p.228_231WFVT>C	C20orf195_uc002yfk.2_In_Frame_Del_p.228_231WFVT>C	NM_024059	NP_076964	Q9BVV2	CT195_HUMAN	hypothetical protein LOC79025	228_231											0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GGCTGCGCTGGTTCGTCACCATCCAGCCA	0.641																		53	200	---	---								-	62187708	GTTCGTCAC	-	62187700	7	5	97	1	0	1	0	1	0	0	0	0	2100	1270	44	0	686	0	C20orf195	20	62187700	In_Frame_Del	DEL	GTTCGTCAC	TCGA-G2-A2ES-01A-11D-A17V-08	4702639	62187700	837820	519	30007										
GMEB2	26205	broad.mit.edu	37	chr20	62229137	62229137	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgatgccgttcatgcggatgGctctcttccagtccttcagg	11	12	3	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr20:62229137G>A	uc002yfp.1	-	4	913	c.434C>T	c.(433-435)GCC>GTC	p.A145V	GMEB2_uc002yfo.1_Missense_Mutation_p.A67V|GMEB2_uc002yfq.1_Missense_Mutation_p.A145V	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	145	SAND.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			CATGCGGATGGCTCTCTTCCA	0.597													0	0	0	0.005443	0	24	48										A	62229137	G	A	62229137	3	1	97	1	0	0	0	0	1	0	0	0	6488	1203	42	2	1182	2	GMEB2	20	62229137	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	41437	62229137	796383	520	30008										
CLDN17	26285	broad.mit.edu	37	chr21	31538933	31538933	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atttgcaagggataaaatgcCattgcctttactttgaagac	8	7	0	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr21:31538933C>T	uc011acv.1	-	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	1	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						GATAAAATGCCATTGCCTTTA	0.468													0	0	0	0.00245	0	15	59										T	31538933	C	T	31538933	3	4	97	1	0	0	0	0	1	0	0	0	3478	594	21	2	675	2	CLDN17	21	31538933	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08		31538933	16590962	521	30009										
GCFC1	94104	broad.mit.edu	37	chr21	34131446	34131446	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accctcgcatttcttgcaaaAatttataccgttcaccaata	3	12	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr21:34131446A>C	uc002yqn.2	-	7	1518	c.1328T>G	c.(1327-1329)TTT>TGT	p.F443C	GCFC1_uc002yqm.2_5'Flank|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.F443C	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	443						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TTCTTGCAAAAATTTATACCG	0.408													0	0	0	0.00361	0	64	156										C	34131446	A	C	34131446	3	2	97	1	0	0	0	0	1	0	0	0	6289	14	1	5	1591	5	GCFC1	21	34131446	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	2592513	34131446	13998449	522	30010										
BRWD1	54014	broad.mit.edu	37	chr21	40574387	40574387	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tgggttccaagataagctgtCctacttgaggtagactgggt	13	7	0	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr21:40574387C>T	uc002yxk.1	-	38	4588	c.4449G>A	c.(4447-4449)AGG>AGA	p.R1483R	BRWD1_uc010goc.1_Silent_p.R126R|BRWD1_uc002yxl.2_Silent_p.R1483R|BRWD1_uc010god.1_Silent_p.R401R	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1483					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GATAAGCTGTCCTACTTGAGG	0.428													0	0	0	0.003954	0	25	50										T	40574387	C	T	40574387	2	4	97	1	0	0	0	0	0	0	0	1	1525	854	30	1		1	BRWD1	21	40574387	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	6442941	40574387	7555508	523	30011										
MX2	4600	broad.mit.edu	37	chr21	42780076	42780076	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagagtgagaccgctaccaaGagaagaatccttaaggagag	12	8	0	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr21:42780076G>A	uc002yzf.1	+	14	2168	c.2064G>A	c.(2062-2064)AAG>AAA	p.K688K	MX2_uc002yzg.1_Silent_p.K411K|MX2_uc010gop.1_Silent_p.K170K	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	688	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CCGCTACCAAGAGAAGAATCC	0.502													0	0	0	0.00361	0	54	65										A	42780076	G	A	42780076	2	1	97	1	0	0	0	0	0	0	0	1	9998	933	33	1		1	MX2	21	42780076	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	2205689	42780076	5349819	524	30012										
PCNT	5116	broad.mit.edu	37	chr21	47769713	47769713	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gagttcaagttcaaagagagCgagaaagaaaaacagctgga	12	5	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr21:47769713C>T	uc002zji.3	+	8	1430	c.1323C>T	c.(1321-1323)AGC>AGT	p.S441S	PCNT_uc002zjj.2_Silent_p.S323S|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	441	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TCAAAGAGAGCGAGAAAGAAA	0.433													0	0	0	0.007835	0	41	66										T	47769713	C	T	47769713	2	4	97	1	0	0	0	0	0	0	0	1	11590	767	27	2		2	PCNT	21	47769713	Silent	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	4989637	47769713	360182	525	30013										
CCT8L2	150160	broad.mit.edu	37	chr22	17072837	17072837	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcgcgcacaccccaacacGctcaggcttgaagctgccgt	10	17	1	1	rs142343817		TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:17072837G>T	uc002zlp.1	-	1	864	c.604C>A	c.(604-606)CGT>AGT	p.R202S		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	202					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACCCCAACACGCTCAGGCTTG	0.612													1	0	7.68411e-24	0.008361	1.02499e-23	29	122										T	17072837	G	T	17072837	3	4	97	1	0	0	0	0	1	0	0	0	2961	1087	38	4	1073	4	CCT8L2	22	17072837	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08		17072837	34231729	526	30014										
BCL2L13	23786	broad.mit.edu	37	chr22	18185037	18185037	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcctctggttttgctacgacAaatgcttttggaattgacaa	9	8	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:18185037A>C	uc002zmw.2	+	6	703	c.485A>C	c.(484-486)CAA>CCA	p.Q162P	BCL2L13_uc002zmu.2_Missense_Mutation_p.Q162P|BCL2L13_uc002zmv.2_Missense_Mutation_p.Q162P|BCL2L13_uc002zmx.2_5'UTR|BCL2L13_uc002zmy.2_Intron|BCL2L13_uc010gqy.2_5'UTR|BCL2L13_uc011agk.1_Missense_Mutation_p.Q38P|BCL2L13_uc010gqz.2_Intron|BCL2L13_uc002zmz.2_5'UTR	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	162					induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		TTGCTACGACAAATGCTTTTG	0.398													0	0	0	0.002222	0	38	162										C	18185037	A	C	18185037	3	2	97	1	0	0	0	0	1	0	0	0	1371	130	5	5	503	5	BCL2L13	22	18185037	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	1112200	18185037	33119529	527	30015										
TRMT2A	27037	broad.mit.edu	37	chr22	20103676	20103676	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cactcgtgttactggtggctCactctcaccctcctgtcgcc	8	17	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:20103676C>T	uc002zrk.1	-	3	699	c.484G>A	c.(484-486)GAG>AAG	p.E162K	TRMT2A_uc002zrl.1_Missense_Mutation_p.E162K|TRMT2A_uc002zrm.1_5'UTR|TRMT2A_uc002zrn.1_Missense_Mutation_p.E162K|TRMT2A_uc011ahk.1_Missense_Mutation_p.E162K|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	162					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						ACTGGTGGCTCACTCTCACCC	0.647													0	0	0	0.002522	0	46	51										T	20103676	C	T	20103676	3	4	97	1	0	0	0	0	1	0	0	0	16562	835	29	1	1437	1	TRMT2A	22	20103676	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1918639	20103676	31200890	528	30016										
ZNRF3	84133	broad.mit.edu	37	chr22	29445244	29445244	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gcaacctctcacgtggtcggCagcagagggtgaccctgccg	14	14	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:29445244C>G	uc003aeg.2	+	8	940	c.775C>G	c.(775-777)CAG>GAG	p.Q259E	ZNRF3_uc003aeh.1_Missense_Mutation_p.Q259E	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	359	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						ACGTGGTCGGCAGCAGAGGGT	0.612													0	0	0	0.004878	0	38	124										G	29445244	C	G	29445244	3	3	97	1	0	0	0	0	1	0	0	0	18210	711	25	4	801	4	ZNRF3	22	29445244	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	9341568	29445244	21859322	529	30017										
SLC35E4	339665	broad.mit.edu	37	chr22	31042720	31042720	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	accgcccactgctggcgactCtcgcctctgggcctgcatcc	10	19	2	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:31042720C>G	uc003ais.1	+	2	1400	c.755C>G	c.(754-756)TCT>TGT	p.S252C	SLC35E4_uc003ait.2_Intron	NM_001001479	NP_001001479	Q6ICL7	S35E4_HUMAN	solute carrier family 35, member E4	252	Leu-rich.					integral to membrane					0						GCTGGCGACTCTCGCCTCTGG	0.667													0	0	0	0.001368	0	12	47										G	31042720	C	G	31042720	3	3	97	1	0	0	0	0	1	0	0	0	14587	913	32	1	761	1	SLC35E4	22	31042720	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	1597476	31042720	20261846	530	30018										
PLA2G6	8398	broad.mit.edu	37	chr22	38536057	38536057	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cccatgatgttgcaccgagcAttgcacagcagcagcacgcg	11	14	0	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:38536057A>T	uc003auy.1	-	5	865	c.729T>A	c.(727-729)AAT>AAA	p.N243K	PLA2G6_uc003auz.1_Missense_Mutation_p.N243K|PLA2G6_uc003ava.1_Missense_Mutation_p.N243K|PLA2G6_uc003avb.2_Missense_Mutation_p.N243K|PLA2G6_uc010gxk.1_RNA|PLA2G6_uc011ano.1_Intron	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	243	ANK 3.				cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	TGCACCGAGCATTGCACAGCA	0.627													0	0	0	0.000978	0	11	46										T	38536057	A	T	38536057	3	4	97	1	0	0	0	0	1	0	0	0	12008	214	8	5	1743	5	PLA2G6	22	38536057	Missense_Mutation	SNP	A	TCGA-G2-A2ES-01A-11D-A17V-08	7493337	38536057	12768509	531	30019										
TTLL12	23170	broad.mit.edu	37	chr22	43570554	43570554	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	gaggatgtcggcgtccgcctCactctgggtgagggtgaagc	17	10	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chr22:43570554C>T	uc003bdq.2	-	7	1017	c.985G>A	c.(985-987)GAG>AAG	p.E329K	TTLL12_uc003bdr.1_Missense_Mutation_p.E329K	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	329	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				GCGTCCGCCTCACTCTGGGTG	0.657													0	0	0	0.003271	0	32	105										T	43570554	C	T	43570554	3	4	97	1	0	0	0	0	1	0	0	0	16722	835	29	1	981	1	TTLL12	22	43570554	Missense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	5034497	43570554	7734012	532	30020										
ACOT9	23597	broad.mit.edu	37	chrX	23748661	23748661	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	tacctcccaagctgtcaagaTcctcaagaatcctgccaaat	5	14	2	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:23748661T>A	uc004dap.2	-	5	502	c.356A>T	c.(355-357)GAT>GTT	p.D119V	ACOT9_uc004dao.2_Missense_Mutation_p.D128V|ACOT9_uc004daq.2_Missense_Mutation_p.D77V|ACOT9_uc004dar.2_Missense_Mutation_p.D59V|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Missense_Mutation_p.D59V|ACOT9_uc004dat.1_Missense_Mutation_p.D119V	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	119					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						GCTGTCAAGATCCTCAAGAAT	0.328													0	0	0	0.00361	0	55	42										A	23748661	T	A	23748661	3	1	97	1	0	0	0	0	1	0	0	0	157	1435	50	5	1007	5	ACOT9	23	23748661	Missense_Mutation	SNP	T	TCGA-G2-A2ES-01A-11D-A17V-08		23748661	131521899	533	30021										
KDM6A	7403	broad.mit.edu	37	chrX	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccagagtgcctagcgtctctCagcctggagtccgtcctgcc	11	16	2	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.004007	0	15	20										T	44922802	C	T	44922802	4	4	97	1	0	0	0	0	0	1	0	0	8137	827	29	1	1725	1	KDM6A	23	44922802	Nonsense_Mutation	SNP	C	TCGA-G2-A2ES-01A-11D-A17V-08	21174141	44922802	110347758	534	30022										
ATRX	546	broad.mit.edu	37	chrX	76919036	76919036	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atctgattcagaattgacttGattttttgcttctaaatgaa	6	5	3	5			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:76919036G>C	uc004ecp.3	-	12	4187	c.3955C>G	c.(3955-3957)CAA>GAA	p.Q1319E	ATRX_uc004ecq.3_Missense_Mutation_p.Q1281E|ATRX_uc004eco.3_Missense_Mutation_p.Q1104E|ATRX_uc004ecr.2_Missense_Mutation_p.Q1251E	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1319					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	GAATTGACTTGATTTTTTGCT	0.358			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.00245	0	14	11										C	76919036	G	C	76919036	3	2	97	1	0	0	0	0	1	0	0	0	1208	1299	45	1	3619	1	ATRX	23	76919036	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	31996234	76919036	78351524	535	30023										
MID2	11043	broad.mit.edu	37	chrX	107169341	107169341	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	caggccaaccctttaaattgGatcccaaaatgactcacaag	6	12	1	1			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:107169341G>A	uc004enl.2	+	9	2188	c.1615G>A	c.(1615-1617)GAT>AAT	p.D539N	MID2_uc004enk.2_Missense_Mutation_p.D509N	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	539	B30.2/SPRY.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						CTTTAAATTGGATCCCAAAAT	0.378													0	0	0	0.004289	0	37	34										A	107169341	G	A	107169341	3	1	97	1	0	0	0	0	1	0	0	0	9578	1174	41	1	1649	1	MID2	23	107169341	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	30250305	107169341	48101219	536	30024										
AMMECR1	9949	broad.mit.edu	37	chrX	109459809	109459823	+	In_Frame_Del	DEL	CCGTGGCAGCTCATC	CCGTGGCAGCTCATC	-													0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	agagacactgagcagaaaagCcgtggcagctcatcccttgt							TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:109459809_109459823delCCGTGGCAGCTCATC	uc004eoo.2	-	3	703_717	c.622_636delGATGAGCTGCCACGG	c.(622-636)GATGAGCTGCCACGGdel	p.DELPR208del	AMMECR1_uc004eop.2_In_Frame_Del_p.DELPR171del|AMMECR1_uc004eoq.2_In_Frame_Del_p.DELPR85del	NM_015365	NP_056180	Q9Y4X0	AMER1_HUMAN	AMMECR1 protein isoform 1	208_212	AMMECR1.										0						AGCAGAAAAGCCGTGGCAGCTCATCCCTTGTCATT	0.377																		23	61	---	---								-	109459823	CCGTGGCAGCTCATC	-	109459809	7	5	97	1	0	1	0	1	0	0	0	0	578	726	26	0	381	0	AMMECR1	23	109459809	In_Frame_Del	DEL	CCGTGGCAGCTCATC	TCGA-G2-A2ES-01A-11D-A17V-08	2290468	109459809	45810751	537	30025										
ZCCHC12	170261	broad.mit.edu	37	chrX	117959285	117959285	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	ccttgggcccattccatgctGaggtccctggggagaagtct	13	12	1	2			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:117959285G>A	uc004equ.2	+	4	551	c.78G>A	c.(76-78)CTG>CTA	p.L26L		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	26					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						ATTCCATGCTGAGGTCCCTGG	0.433													0	0	0	0.002222	0	45	28										A	117959285	G	A	117959285	2	1	97	1	0	0	0	0	0	0	0	1	17578	1277	45	1		1	ZCCHC12	23	117959285	Silent	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	8499476	117959285	37311275	538	30026										
PHF6	84295	broad.mit.edu	37	chrX	133511786	133511786	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	cagcgcaccataagtgcatgGtaagtataccggcagcaaca	10	11	0	0			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:133511786G>A	uc004exj.2	+	2	340	c.138_splice	c.e2+1	p.M46_splice	PHF6_uc004exk.2_Splice_Site_p.M46_splice|PHF6_uc011mvk.1_Splice_Site_p.M46_splice|PHF6_uc004exh.2_Splice_Site_p.M46_splice|PHF6_uc010nrr.2_Splice_Site_p.M46_splice|PHF6_uc004exi.2_Splice_Site_p.M46_splice	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TAAGTGCATGGTAAGTATACC	0.378													0	0	0	0.004878	0	36	30										A	133511786	G	A	133511786	5	1	97	1	0	0	0	0	0	0	1	0	11838	1275	44	2	141	2	PHF6	23	133511786	Splice_Site	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	15552501	133511786	21758774	539	30027										
ZNF185	7739	broad.mit.edu	37	chrX	152128422	152128422	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.269158878504673	144	2.19650370517762e-37	3.12366710013004	3.76487183443169	2.97872043605419	8.22950625957998e-20	2.13967162749079e-18	98	atctgagcaattcgtcagacGagagagctgcaccagcaggt	12	10	2	3			TCGA-G2-A2ES-01A-11D-A17V-08	TCGA-G2-A2ES-11A-31D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5c628df6-a848-4177-87b8-714788118980	d637d039-a319-4a5d-a99e-54e8f81096e7	g.chrX:152128422G>T	uc010ntv.1	+	17	1623	c.1586G>T	c.(1585-1587)CGA>CTA	p.R529L	ZNF185_uc011myg.1_Missense_Mutation_p.R561L|ZNF185_uc011myh.1_Missense_Mutation_p.R532L|ZNF185_uc011myi.1_Missense_Mutation_p.R500L|ZNF185_uc011myj.1_Missense_Mutation_p.R470L|ZNF185_uc011myk.1_Missense_Mutation_p.R530L|ZNF185_uc004fgw.3_Missense_Mutation_p.R308L|ZNF185_uc004fgu.2_Missense_Mutation_p.R158L|ZNF185_uc004fgv.2_Missense_Mutation_p.R226L|ZNF185_uc004fgx.2_Missense_Mutation_p.R167L	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	529						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTCGTCAGACGAGAGAGCTGC	0.582													1	0	1.6384e-10	0.001984	2.08208e-10	5	9										T	152128422	G	T	152128422	3	4	97	1	0	0	0	0	1	0	0	0	17749	1058	37	3	1896	3	ZNF185	23	152128422	Missense_Mutation	SNP	G	TCGA-G2-A2ES-01A-11D-A17V-08	18616636	152128422	3142138	540	30028										
HTR1D	3352	broad.mit.edu	37	chr1	23519904	23519904	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cgtggttgaaaaagagagggGagccagccgagtgcgagtgc	18	7	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:23519904G>A	uc001bgn.2	-	1	1319	c.809C>T	c.(808-810)TCC>TTC	p.S270F		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	270	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	AAAGAGAGGGGAGCCAGCCGA	0.572													0	0	0	0.021022	0	34	46										A	23519904	G	A	23519904	3	1	98	1	0	0	0	0	1	0	0	0	7438	1174	41	1	328	1	HTR1D	1	23519904	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		23519904	225730717	1	30029										
CYP4A22	284541	broad.mit.edu	37	chr1	47603170	47603170	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gctgcaccatgagtgtctctGtcctgagccccagcagacgc	11	15	1	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:47603170G>T	uc001cqv.1	+	1	64	c.13G>T	c.(13-15)GTC>TTC	p.V5F	CYP4A22_uc009vyo.2_Missense_Mutation_p.V5F|CYP4A22_uc009vyp.2_Missense_Mutation_p.V5F	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	5						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						GAGTGTCTCTGTCCTGAGCCC	0.587													1	0	3.10996e-30	0.01441	4.51249e-30	43	75										T	47603170	G	T	47603170	3	4	98	1	0	0	0	0	1	0	0	0	4184	1377	48	4	15	4	CYP4A22	1	47603170	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	24083266	47603170	201647451	2	30030										
ELAVL4	1996	broad.mit.edu	37	chr1	50610812	50610812	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cccaagaagaattcaggagtCtcttcgggagcattggtgaa	12	8	2	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:50610812C>T	uc001csb.2	+	2	461	c.193C>T	c.(193-195)CTC>TTC	p.L65F	ELAVL4_uc001cry.3_Missense_Mutation_p.L68F|ELAVL4_uc001crz.3_Missense_Mutation_p.L65F|ELAVL4_uc001csa.3_Missense_Mutation_p.L82F|ELAVL4_uc001csc.3_Missense_Mutation_p.L65F|ELAVL4_uc009vyu.2_Missense_Mutation_p.L70F|ELAVL4_uc010omz.1_Missense_Mutation_p.L70F	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	65	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						ATTCAGGAGTCTCTTCGGGAG	0.433													0	0	0	0.003163	0	13	78										T	50610812	C	T	50610812	3	4	98	1	0	0	0	0	1	0	0	0	5052	913	32	1	298	1	ELAVL4	1	50610812	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	3007642	50610812	198639809	3	30031										
COL11A1	1301	broad.mit.edu	37	chr1	103461428	103461428	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	attaaattttaccttttcacCtttagatcccttgagacctc	3	11	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:103461428C>A	uc001dul.2	-	28	2650	c.2332G>T	c.(2332-2334)GGT>TGT	p.G778C	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.G790C|COL11A1_uc001dun.2_Missense_Mutation_p.G739C|COL11A1_uc009weh.2_Missense_Mutation_p.G662C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	778	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCTTTTCACCTTTAGATCCC	0.269													1	0	8.52622e-23	0.01441	1.15769e-22	52	40										A	103461428	C	A	103461428	3	1	98	1	0	0	0	0	1	0	0	0	3667	681	24	4	3248	4	COL11A1	1	103461428	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	52850616	103461428	145789193	4	30032										
KCNC4	3749	broad.mit.edu	37	chr1	110754241	110754241	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gcgtcggagaagatcatcatCaacgtgggcggcacgcgaca	14	11	3	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:110754241C>T	uc001dzh.2	+	1	177	c.120C>T	c.(118-120)ATC>ATT	p.I40I	KCNC4_uc001dzf.2_Silent_p.I40I|KCNC4_uc009wfr.2_Silent_p.I40I|KCNC4_uc001dzg.2_Silent_p.I40I|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	40	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGATCATCATCAACGTGGGCG	0.677													0	0	0	0.004656	0	20	35										T	110754241	C	T	110754241	2	4	98	1	0	0	0	0	0	0	0	1	8017	816	29	1		1	KCNC4	1	110754241	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	7292813	110754241	138496380	5	30033										
SPAG17	200162	broad.mit.edu	37	chr1	118537064	118537064	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgtttcccatgaccttgaccGgagattaggagggacaattg	12	8	0	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:118537064G>T	uc001ehk.2	-	35	5211	c.5143C>A	c.(5143-5145)CGG>AGG	p.R1715R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1715						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GACCTTGACCGGAGATTAGGA	0.428													1	0	6.70999e-13	0.019004	7.88157e-13	27	49										T	118537064	G	T	118537064	2	4	98	1	0	0	0	0	0	0	0	1	14979	1115	39	4		4	SPAG17	1	118537064	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	7782823	118537064	130713557	6	30034										
OR6Y1	391112	broad.mit.edu	37	chr1	158517011	158517011	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	acttcatggttcctcagacaGtaaatgatggggttgaggag	13	6	2	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:158517011G>T	uc010pil.1	-	1	885	c.885C>A	c.(883-885)TAC>TAA	p.Y295*		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	295	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCTCAGACAGTAAATGATGG	0.458													1	0	1.81118e-26	0.01441	2.57745e-26	40	67										T	158517011	G	T	158517011	4	4	98	1	0	0	0	0	0	1	0	0	11213	1024	36	4	94	4	OR6Y1	1	158517011	Nonsense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	39979947	158517011	90733610	7	30035										
KIFAP3	22920	broad.mit.edu	37	chr1	169951164	169951164	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gccagatttggctagcaatgCagcacaagagtcatccatgg	11	10	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:169951164C>A	uc001ggv.2	-	15	2018	c.1747G>T	c.(1747-1749)GCA>TCA	p.A583S	KIFAP3_uc010plx.1_Missense_Mutation_p.A285S	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	583	ARM 4.				blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTAGCAATGCAGCACAAGAG	0.348													1	0	2.4375e-19	0.007291	3.13695e-19	23	31										A	169951164	C	A	169951164	3	1	98	1	0	0	0	0	1	0	0	0	8311	710	25	4	655	4	KIFAP3	1	169951164	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	11434153	169951164	79299457	8	30036										
LGR6	59352	broad.mit.edu	37	chr1	202205106	202205106	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	agaggcgctgtgggagctgcCgagcctgcagtcgctgtgag	18	10	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:202205106C>G	uc001gxu.2	+	4	413	c.413C>G	c.(412-414)CCG>CGG	p.P138R	LGR6_uc001gxv.2_Missense_Mutation_p.P86R|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.P95R|LGR6_uc009xac.1_5'Flank	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	138	Extracellular (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10						TGGGAGCTGCCGAGCCTGCAG	0.607													0	0	0	0.004672	0	3	56										G	202205106	C	G	202205106	3	3	98	1	0	0	0	0	1	0	0	0	8758	652	23	4	574	4	LGR6	1	202205106	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	32253942	202205106	47045515	9	30037										
CHRM3	1131	broad.mit.edu	37	chr1	240071577	240071577	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aagcctctgggacagaggcaGagacagaaaactttgtccac	11	10	1	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr1:240071577G>A	uc001hyp.2	+	5	1605	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	276	Basolateral sorting signal.|Cytoplasmic (By similarity).			E->D: Loss of basolateral sorting. No effect on basolateral sorting; when associated with L-280 and L-281.|E->A: Loss of basolateral sorting.	cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GACAGAGGCAGAGACAGAAAA	0.488													0	0	0	0.008871	0	17	26										A	240071577	G	A	240071577	3	1	98	1	0	0	0	0	1	0	0	0	3378	943	33	1	828	1	CHRM3	1	240071577	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	37866471	240071577	9179044	10	30038										
C2orf42	54980	broad.mit.edu	37	chr2	70392226	70392226	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atagaaataaactctcacctCtggggtatctaagatttgtt	7	7	3	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:70392226C>T	uc002sgh.2	-	8	1679	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	451											0						ACTCTCACCTCTGGGGTATCT	0.428													0	0	0	0.01441	0	44	55										T	70392226	C	T	70392226	3	4	98	1	0	0	0	0	1	0	0	0	2166	922	32	1	385	1	C2orf42	2	70392226	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		70392226	172807147	11	30039										
C2orf42	54980	broad.mit.edu	37	chr2	70392294	70392294	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aagtatacttggaaaaggttCccagtggcaaggcatctttc	10	8	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:70392294C>G	uc002sgh.2	-	8	1611	c.1283G>C	c.(1282-1284)GGA>GCA	p.G428A		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	428											0						GGAAAAGGTTCCCAGTGGCAA	0.353													0	0	0	0.009535	0	28	30										G	70392294	C	G	70392294	3	3	98	1	0	0	0	0	1	0	0	0	2166	855	30	1	453	1	C2orf42	2	70392294	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	68	70392294	172807079	12	30040										
ZNF638	27332	broad.mit.edu	37	chr2	71651159	71651159	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atcatgaaacgggatgacagCaacaataaggtgaggagggt	14	5	1	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:71651159C>A	uc002shx.2	+	22	4834	c.4515C>A	c.(4513-4515)AGC>AGA	p.S1505R	ZNF638_uc010yqw.1_Missense_Mutation_p.S1084R|ZNF638_uc002shy.2_Missense_Mutation_p.S1505R|ZNF638_uc002shz.2_Missense_Mutation_p.S1505R|ZNF638_uc002sia.2_Missense_Mutation_p.S1505R|ZNF638_uc002sib.1_Intron|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Missense_Mutation_p.S602R|ZNF638_uc002sid.2_Intron	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1505					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGGATGACAGCAACAATAAGG	0.433													1	0	8.28177e-16	0.007413	1.02142e-15	15	28										A	71651159	C	A	71651159	3	1	98	1	0	0	0	0	1	0	0	0	18052	709	25	4	4597	4	ZNF638	2	71651159	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	1258865	71651159	171548214	13	30041										
C2orf3	6936	broad.mit.edu	37	chr2	75915023	75915023	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ttatctgaactactttccttCtttgaatcttccacactgct	3	12	3	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:75915023C>T	uc002sno.2	-	11	1750	c.1620G>A	c.(1618-1620)AAG>AAA	p.K540K	C2orf3_uc010ffs.2_Silent_p.K102K|C2orf3_uc002snn.2_Silent_p.K371K|C2orf3_uc010fft.2_Silent_p.K215K	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	540					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TACTTTCCTTCTTTGAATCTT	0.338													0	0	0	0.00499	0	15	35										T	75915023	C	T	75915023	2	4	98	1	0	0	0	0	0	0	0	1	2162	912	32	1		1	C2orf3	2	75915023	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	4263864	75915023	167284350	14	30042										
CTNNA2	1496	broad.mit.edu	37	chr2	80101255	80101255	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gcagccgcccgaggggctctGaagaagaatgccacaatgct	13	12	1	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:80101255G>A	uc010ysh.1	+	5	644	c.639G>A	c.(637-639)CTG>CTA	p.L213L	CTNNA2_uc010yse.1_Silent_p.L213L|CTNNA2_uc010ysf.1_Silent_p.L213L|CTNNA2_uc010ysg.1_Silent_p.L213L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	213					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAGGGGCTCTGAAGAAGAATG	0.517													0	0	0	0.007291	0	26	23										A	80101255	G	A	80101255	2	1	98	1	0	0	0	0	0	0	0	1	4013	1277	45	1		1	CTNNA2	2	80101255	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	4186232	80101255	163098118	15	30043										
MFSD9	84804	broad.mit.edu	37	chr2	103353184	103353184	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cggcagcctccgcctcggttCctgtcttctgctcctgtttc	9	17	2	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:103353184C>T	uc002tcb.2	-	1	154	c.86G>A	c.(85-87)GGA>GAA	p.G29E	TMEM182_uc002tcc.3_5'Flank|TMEM182_uc002tcd.3_5'Flank|MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	29					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						CGCCTCGGTTCCTGTCTTCTG	0.677													0	0	0	0.012319	0	22	28										T	103353184	C	T	103353184	3	4	98	1	0	0	0	0	1	0	0	0	9539	855	30	1	1362	1	MFSD9	2	103353184	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	23251929	103353184	139846189	16	30044										
TFCP2L1	29842	broad.mit.edu	37	chr2	122038802	122038802	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cgggcctcgttctcgggggaCagctggggttcctcctgctt	15	13	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:122038802C>A	uc002tmx.2	-	2	201	c.108G>T	c.(106-108)CTG>CTT	p.L36L	TFCP2L1_uc010flr.2_Silent_p.L36L	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	36	Mediate transcriptional repression.				female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					TCTCGGGGGACAGCTGGGGTT	0.622													1	0	6.20995e-33	0.01441	9.09973e-33	63	115										A	122038802	C	A	122038802	2	1	98	1	0	0	0	0	0	0	0	1	15793	465	17	4		4	TFCP2L1	2	122038802	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	18685618	122038802	121160571	17	30045										
SCN1A	6323	broad.mit.edu	37	chr2	166848518	166848518	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ttccaacagatgggttcccaCagtctcccttaactgagctt	7	13	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:166848518C>A	uc010zcz.1	-	26	5252	c.5234G>T	c.(5233-5235)TGT>TTT	p.C1745F		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1756	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGGGTTCCCACAGTCTCCCTT	0.468													1	0	1.07363e-35	0.01441	1.60502e-35	60	105										A	166848518	C	A	166848518	3	1	98	1	0	0	0	0	1	0	0	0	13914	478	17	4	766	4	SCN1A	2	166848518	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	44809716	166848518	76350855	18	30046										
XIRP2	129446	broad.mit.edu	37	chr2	168105238	168105238	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atttttcccccaaagttgaaCtggcaacctccctgtcagat	6	13	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:168105238C>A	uc002udx.2	+	8	7354	c.7336C>A	c.(7336-7338)CTG>ATG	p.L2446M	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.L2271M|XIRP2_uc010fpq.2_Missense_Mutation_p.L2224M|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2271					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CAAAGTTGAACTGGCAACCTC	0.423													1	0	9.58827e-17	0.01441	1.19249e-16	41	59										A	168105238	C	A	168105238	3	1	98	1	0	0	0	0	1	0	0	0	17427	564	20	4	7366	4	XIRP2	2	168105238	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	1256720	168105238	75094135	19	30047										
NFE2L2	4780	broad.mit.edu	37	chr2	178098945	178098945	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	actgaagtcaaatacttctcGacttactccaagatctatat	4	10	3	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.007413	0	18	7										C	178098945	G	C	178098945	3	2	98	1	0	0	0	0	1	0	0	0	10368	1066	37	1	1733	1	NFE2L2	2	178098945	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	9993707	178098945	65100428	20	30048										
EEF1B2	1933	broad.mit.edu	37	chr2	207026135	207026135	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgtggaagacactacaggaaGtggagctacagatagtaaag	13	5	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr2:207026135G>C	uc002vbf.1	+	4	427	c.269G>C	c.(268-270)AGT>ACT	p.S90T	NDUFS1_uc010ziq.1_5'Flank|NDUFS1_uc002vbe.2_5'Flank|NDUFS1_uc010zir.1_5'Flank|NDUFS1_uc010zis.1_5'Flank|NDUFS1_uc010zit.1_5'Flank|NDUFS1_uc010ziu.1_5'Flank|EEF1B2_uc002vbg.1_Missense_Mutation_p.S90T|EEF1B2_uc002vbh.1_Missense_Mutation_p.S90T|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.2_5'Flank	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	90						cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						ACTACAGGAAGTGGAGCTACA	0.393													0	0	0	0.01441	0	58	80										C	207026135	G	C	207026135	3	2	98	1	0	0	0	0	1	0	0	0	4925	1029	36	4	279	4	EEF1B2	2	207026135	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	28927190	207026135	36173238	21	30049										
TGFBR2	7048	broad.mit.edu	37	chr3	30715617	30715617	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gtgggaactgcaagatacatGgctccagaagtcctagaatc	11	9	0	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:30715617G>T	uc003ceo.2	+	5	1657	c.1275G>T	c.(1273-1275)ATG>ATT	p.M425I	TGFBR2_uc003cen.2_Missense_Mutation_p.M450I	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	425	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						CAAGATACATGGCTCCAGAAG	0.453													1	0	6.53348e-20	0.017118	8.48206e-20	26	6										T	30715617	G	T	30715617	3	4	98	1	0	0	0	0	1	0	0	0	15819	1348	47	4	1372	4	TGFBR2	3	30715617	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		30715617	167306813	22	30050										
C3orf67	200844	broad.mit.edu	37	chr3	58849547	58849547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgggttgcaggagtcatcacCcagaagtagagactgtctgc	13	9	3	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:58849547C>T	uc003dkt.1	-	12	1364	c.955G>A	c.(955-957)GGT>AGT	p.G319S	C3orf67_uc003dks.1_Missense_Mutation_p.G134S|uc003dku.1_Intron|C3orf67_uc003dkv.1_Missense_Mutation_p.G134S|C3orf67_uc003dkw.2_Missense_Mutation_p.G214S	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	319											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		GAGTCATCACCCAGAAGTAGA	0.463													0	0	0	0.007835	0	39	3										T	58849547	C	T	58849547	3	4	98	1	0	0	0	0	1	0	0	0	2241	623	22	2	756	2	C3orf67	3	58849547	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	28133930	58849547	139172883	23	30051										
TOPBP1	11073	broad.mit.edu	37	chr3	133341937	133341937	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aaaaataaaatattttacctCctttagagtcattctttcca	2	8	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:133341937C>G	uc003eps.2	-	19	3308	c.3176G>C	c.(3175-3177)GGA>GCA	p.G1059A	TOPBP1_uc003ept.1_Missense_Mutation_p.G63A	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1059					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						tattttaCCTCCTTTAGAGTC	0.229								Other_conserved_DNA_damage_response_genes					0	0	0	0.008291	0	8	0										G	133341937	C	G	133341937	3	3	98	1	0	0	0	0	1	0	0	0	16366	855	30	1	1432	1	TOPBP1	3	133341937	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	74492390	133341937	64680493	24	30052										
HRG	3273	broad.mit.edu	37	chr3	186389456	186389456	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aagatagtccggtcctcataGatttctttgaggatactgag	10	7	2	4			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:186389456G>T	uc003fqq.2	+	4	459	c.436G>T	c.(436-438)GAT>TAT	p.D146Y		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	146	Cystatin 2.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GGTCCTCATAGATTTCTTTGA	0.453													1	0	1.06801e-11	0.009535	1.23489e-11	28	26										T	186389456	G	T	186389456	3	4	98	1	0	0	0	0	1	0	0	0	7354	942	33	3	450	3	HRG	3	186389456	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	53047519	186389456	11632974	25	30053										
PCYT1A	5130	broad.mit.edu	37	chr3	195975136	195975136	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gcttgcatcagagctcgggcGtgaccagagtgaaataagtc	13	9	1	4			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr3:195975136G>A	uc003fwg.2	-	5	449	c.276C>T	c.(274-276)CAC>CAT	p.H92H	PCYT1A_uc003fwh.2_Silent_p.H92H	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	92	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	GAGCTCGGGCGTGACCAGAGT	0.413													0	0	0	0.001168	0	4	107										A	195975136	G	A	195975136	2	1	98	1	0	0	0	0	0	0	0	1	11610	1136	40	2		2	PCYT1A	3	195975136	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	9585680	195975136	2047294	26	30054										
UGT2B4	7363	broad.mit.edu	37	chr4	70355258	70355258	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aaacaccacaacaccattttCtccagagctctggacaaact	4	14	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:70355258C>T	uc003hek.3	-	3	948	c.901G>A	c.(901-903)GAA>AAA	p.E301K	UGT2B4_uc011cap.1_Missense_Mutation_p.E165K|UGT2B4_uc003hel.3_Missense_Mutation_p.E301K	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	301					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ACACCATTTTCTCCAGAGCTC	0.403													0	0	0	0.01441	0	69	16										T	70355258	C	T	70355258	3	4	98	1	0	0	0	0	1	0	0	0	16958	922	32	1	701	1	UGT2B4	4	70355258	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		70355258	120799018	27	30055										
MAPK10	5602	broad.mit.edu	37	chr4	87022213	87022213	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aagcatccctaccgttctccTtgtagcccatccccaggatg	7	16	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:87022213T>G	uc003hpq.2	-	7	789	c.722A>C	c.(721-723)AAG>ACG	p.K241T	MAPK10_uc010ikg.2_Missense_Mutation_p.K203T|MAPK10_uc003hpr.2_Missense_Mutation_p.K203T|MAPK10_uc003hps.2_Missense_Mutation_p.K241T|MAPK10_uc003hpt.2_Missense_Mutation_p.K241T|MAPK10_uc003hpu.2_Missense_Mutation_p.K241T|MAPK10_uc003hpv.2_Missense_Mutation_p.K96T|MAPK10_uc003hpn.2_5'Flank|MAPK10_uc003hpo.2_Missense_Mutation_p.K96T|MAPK10_uc011ccw.1_Missense_Mutation_p.K127T|MAPK10_uc003hpp.2_Missense_Mutation_p.K96T	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	241	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		ACCGTTCTCCTTGTAGCCCAT	0.498													0	0	0	0.01441	0	39	11										G	87022213	T	G	87022213	3	3	98	1	0	0	0	0	1	0	0	0	9272	1609	56	5	705	5	MAPK10	4	87022213	Missense_Mutation	SNP	T	TCGA-G2-A3IB-01A-11D-A20D-08	16666955	87022213	104132063	28	30056										
EGF	1950	broad.mit.edu	37	chr4	110884383	110884383	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gctctgcgttcctcttagccCagtatcctgggaatgtgatt	10	11	2	1	rs150311153	byFrequency	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:110884383C>A	uc003hzy.3	+	9	1819	c.1367C>A	c.(1366-1368)CCA>CAA	p.P456Q	EGF_uc011cfu.1_Missense_Mutation_p.P414Q|EGF_uc011cfv.1_Missense_Mutation_p.P456Q	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	456	EGF-like 4.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	CCTCTTAGCCCAGTATCCTGG	0.448													1	0	8.84886e-50	0.01441	1.39323e-49	83	19										A	110884383	C	A	110884383	3	1	98	1	0	0	0	0	1	0	0	0	4962	594	21	4	1401	4	EGF	4	110884383	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	23862170	110884383	80269893	29	30057										
DCLK2	166614	broad.mit.edu	37	chr4	151023702	151023702	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	caaaaatattaatccaaactGgtctgtgaacatcaagggtg	8	7	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr4:151023702G>T	uc003ilm.3	+	2	594	c.494G>T	c.(493-495)TGG>TTG	p.W165L	DCLK2_uc003iln.3_Missense_Mutation_p.W165L|DCLK2_uc003ilo.3_Missense_Mutation_p.W165L|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	165					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					AATCCAAACTGGTCTGTGAAC	0.393													1	0	2.19489e-29	0.00623	3.15382e-29	29	4										T	151023702	G	T	151023702	3	4	98	1	0	0	0	0	1	0	0	0	4292	1357	47	4	500	4	DCLK2	4	151023702	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	40139319	151023702	40130574	30	30058										
SLC6A19	340024	broad.mit.edu	37	chr5	1219713	1219713	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gctggacagctatgccggctCcattcccctgctcatcatcg	9	16	2	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:1219713C>T	uc003jbw.3	+	10	1528	c.1472C>T	c.(1471-1473)TCC>TTC	p.S491F		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	491	Helical; Name=10; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TATGCCGGCTCCATTCCCCTG	0.592													0	0	0	0.010818	0	30	80										T	1219713	C	T	1219713	3	4	98	1	0	0	0	0	1	0	0	0	14682	855	30	1	1510	1	SLC6A19	5	1219713	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		1219713	179695547	31	30059										
ADAMTS12	81792	broad.mit.edu	37	chr5	33614431	33614431	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tcattgtcaaggccatctttCtggattgtgtactcatactt	7	9	5	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:33614431C>A	uc003jia.1	-	16	2602	c.2439G>T	c.(2437-2439)CAG>CAT	p.Q813H	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q728H	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	813	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGCCATCTTTCTGGATTGTGT	0.478										HNSCC(64;0.19)			1	0	3.1745e-13	0.008361	3.7586e-13	21	72										A	33614431	C	A	33614431	3	1	98	1	0	0	0	0	1	0	0	0	257	912	32	3	2381	3	ADAMTS12	5	33614431	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	32394718	33614431	147300829	32	30060										
CMYA5	202333	broad.mit.edu	37	chr5	79027444	79027444	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tctccagattctgcatttgtGtcagaattctcatttccacc	5	12	4	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:79027444G>T	uc003kgc.2	+	2	2928	c.2856G>T	c.(2854-2856)GTG>GTT	p.V952V		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	952						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTGCATTTGTGTCAGAATTCT	0.393													1	0	1.64293e-13	0.01892	1.96092e-13	20	2										T	79027444	G	T	79027444	2	4	98	1	0	0	0	0	0	0	0	1	3590	1364	48	4		4	CMYA5	5	79027444	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	45413013	79027444	101887816	33	30061										
EPB41L4A	64097	broad.mit.edu	37	chr5	111576460	111576460	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ctgcacttccagaggtgcttGcaagcagttttactccgagc	10	12	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr5:111576460G>T	uc003kpv.1	-	10	1117	c.843C>A	c.(841-843)TGC>TGA	p.C281*		NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	281	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		AGAGGTGCTTGCAAGCAGTTT	0.343													1	0	1.48458e-05	0.017118	1.61557e-05	24	6										T	111576460	G	T	111576460	4	4	98	1	0	0	0	0	0	1	0	0	5155	1311	46	4	1273	4	EPB41L4A	5	111576460	Nonsense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	32549016	111576460	69338800	34	30062										
TNXB	7148	broad.mit.edu	37	chr6	32029938	32029938	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cccatcgtccactcacctgtCaccccgatggcagacacggg	9	18	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr6:32029938C>A	uc003nzl.2	-	20	7366	c.7164G>T	c.(7162-7164)GTG>GTT	p.V2388V		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2450					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACTCACCTGTCACCCCGATGG	0.627													1	0	3.45872e-05	0.004007	3.73642e-05	14	16										A	32029938	C	A	32029938	2	1	98	1	0	0	0	0	0	0	0	1	16343	813	29	3		3	TNXB	6	32029938	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		32029938	139085129	35	30063										
CDKN1A	1026	broad.mit.edu	37	chr6	36652020	36652020	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gcatccaggaggcccgtgagCgatggaacttcgactttgtc	13	11	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr6:36652020C>T	uc003omm.3	+	2	264	c.142C>T	c.(142-144)CGA>TGA	p.R48*	CDKN1A_uc011dtq.1_Nonsense_Mutation_p.R82*|CDKN1A_uc003oml.2_Nonsense_Mutation_p.R48*|CDKN1A_uc003omn.2_Nonsense_Mutation_p.R48*	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	48					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GGCCCGTGAGCGATGGAACTT	0.662									Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.012213	0	29	58										T	36652020	C	T	36652020	4	4	98	1	0	0	0	0	0	1	0	0	3158	760	27	2	144	2	CDKN1A	6	36652020	Nonsense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	4622082	36652020	134463047	36	30064										
AMPH	273	broad.mit.edu	37	chr7	38500927	38500927	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ttctggaacaaagttgtcctCaaagaaactgatgatgttct	8	7	3	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:38500927C>T	uc003tgu.2	-	11	1042	c.973G>A	c.(973-975)GAG>AAG	p.E325K	AMPH_uc003tgv.2_Missense_Mutation_p.E325K|AMPH_uc003tgt.2_Missense_Mutation_p.E78K	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	325					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						AAGTTGTCCTCAAAGAAACTG	0.488													0	0	0	0.01441	0	54	79										T	38500927	C	T	38500927	3	4	98	1	0	0	0	0	1	0	0	0	588	835	29	1	1158	1	AMPH	7	38500927	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		38500927	120637736	37	30065										
ZNF735	730291	broad.mit.edu	37	chr7	63680313	63680313	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gagaattcatactggagagaGaccctacaaatgtgaagaat	10	6	1	5			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:63680313G>A	uc011kdn.1	+	4	884	c.884G>A	c.(883-885)AGA>AAA	p.R295K		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTGGAGAGAGACCCTACAAA	0.448													0	0	0	0.004672	0	3	77										A	63680313	G	A	63680313	3	1	98	1	0	0	0	0	1	0	0	0	18121	942	33	1	898	1	ZNF735	7	63680313	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	25179386	63680313	95458350	38	30066										
OR2A12	346525	broad.mit.edu	37	chr7	143793013	143793013	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cattctcaagaacggaggaaGatcctttccctgttttacag	8	10	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:143793013G>C	uc011kty.1	+	1	813	c.813G>C	c.(811-813)AAG>AAC	p.K271N		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					AACGGAGGAAGATCCTTTCCC	0.522													0	0	0	0.001984	0	6	262										C	143793013	G	C	143793013	3	2	98	1	0	0	0	0	1	0	0	0	10975	933	33	1	815	1	OR2A12	7	143793013	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	80112700	143793013	15345650	39	30067										
EZH2	2146	broad.mit.edu	37	chr7	148511213	148511213	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgtgctttgcagcggcatccCggaaagcggttttgaccttc	12	11	0	1	rs144723981		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:148511213C>A	uc003wfd.1	-	15	1840	c.1674G>T	c.(1672-1674)CCG>CCT	p.P558P	EZH2_uc011kug.1_Silent_p.P507P|EZH2_uc003wfb.1_Silent_p.P563P|EZH2_uc003wfc.1_Silent_p.P519P|EZH2_uc011kuh.1_Silent_p.P549P	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	558	Cys-rich.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			AGCGGCATCCCGGAAAGCGGT	0.473			Mis		DLBCL								1	0	2.43516e-34	0.01441	3.60404e-34	65	103										A	148511213	C	A	148511213	2	1	98	1	0	0	0	0	0	0	0	1	5334	639	23	4		4	EZH2	7	148511213	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	4718200	148511213	10627450	40	30068										
RBM33	155435	broad.mit.edu	37	chr7	155531073	155531074	+	Frame_Shift_Del	DEL	CA	CA	-													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ccaggacagccgtttctgccCacacacacacagcccaacct							TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr7:155531073_155531074delCA	uc010lqk.1	+	11	2081_2082	c.1713_1714delCA	c.(1711-1716)CCCACAfs	p.P571fs	RBM33_uc011kvv.1_Frame_Shift_Del_p.P380fs	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	571_572	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CGTTTCTGCCCACACACACACA	0.53																		7	113	---	---								-	155531074	CA	-	155531073	7	5	98	1	0	1	0	1	0	0	0	0	13130	581	21	0	1755	0	RBM33	7	155531073	Frame_Shift_Del	DEL	CA	TCGA-G2-A3IB-01A-11D-A20D-08	7019860	155531073	3607590	41	30069										
MYOM2	9172	broad.mit.edu	37	chr8	2040194	2040194	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ttgtcccttctgctccgggtCgggttcttgcttcccgaaac	10	14	2	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:2040194C>T	uc003wpx.3	+	16	1987	c.1849C>T	c.(1849-1851)CGG>TGG	p.R617W	MYOM2_uc011kwi.1_Missense_Mutation_p.R42W	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	617	Fibronectin type-III 3.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGCTCCGGGTCGGGTTCTTGC	0.547													0	0	0	0.01441	0	98	131										T	2040194	C	T	2040194	3	4	98	1	0	0	0	0	1	0	0	0	10092	875	31	1	1907	1	MYOM2	8	2040194	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		2040194	144323828	42	30070										
PCM1	5108	broad.mit.edu	37	chr8	17868136	17868137	+	Frame_Shift_Ins	INS	-	-	TC													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggctaaaaggattcttgaagINSatcatggctcacctgctgga							TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:17868136_17868137insTC	uc003wyi.3	+	32	5601_5602	c.5179_5180insTC	c.(5179-5181)GATfs	p.D1727fs	PCM1_uc011kyh.1_Frame_Shift_Ins_p.D1719fs|PCM1_uc003wyj.3_Frame_Shift_Ins_p.D1673fs|PCM1_uc011kyi.1_Frame_Shift_Ins_p.D526fs|PCM1_uc011kyj.1_Frame_Shift_Ins_p.D483fs|PCM1_uc003wyk.3_Frame_Shift_Ins_p.D409fs|PCM1_uc011kyk.1_Frame_Shift_Ins_p.D343fs	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	1727	Interaction with HAP1.				centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		GATTCTTGAAGATCATGGCTCA	0.218			T	RET|JAK2	papillary thyroid|CML|MPD													12	15	---	---								TC	17868137	-	TC	17868136	7	5	98	1	0	1	1	0	0	0	0	0	11584	942	33	0	5297	0	PCM1	8	17868136	Frame_Shift_Ins	INS	-	TCGA-G2-A3IB-01A-11D-A20D-08	15827942	17868136	128495886	43	30071										
RP1	6101	broad.mit.edu	37	chr8	55542115	55542115	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gctattaaaaaccaaccattGcctggcagtaatatgattca	6	9	1	1	rs139088785	byFrequency	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:55542115G>T	uc003xsd.1	+	4	5821	c.5673G>T	c.(5671-5673)TTG>TTT	p.L1891F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1891					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ACCAACCATTGCCTGGCAGTA	0.388													1	0	3.90053e-15	0.012213	4.73179e-15	30	50										T	55542115	G	T	55542115	3	4	98	1	0	0	0	0	1	0	0	0	13532	1310	46	4	5683	4	RP1	8	55542115	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	37673979	55542115	90821907	44	30072										
PRDM14	63978	broad.mit.edu	37	chr8	70970924	70970924	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gaagaatgtggatccgaagcCggtcccgcttctcaaaggat	12	10	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:70970924C>T	uc003xym.2	-	6	1539	c.1337G>A	c.(1336-1338)CGG>CAG	p.R446Q		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	446	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GATCCGAAGCCGGTCCCGCTT	0.507													0	0	0	0.015359	0	29	42										T	70970924	C	T	70970924	3	4	98	1	0	0	0	0	1	0	0	0	12455	652	23	2	390	2	PRDM14	8	70970924	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	15428809	70970924	75393098	45	30073										
FAM91A1	157769	broad.mit.edu	37	chr8	124787454	124787454	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aagtacagccgagatcatctCatgctgtacccttaccatct	6	13	3	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr8:124787454C>T	uc003yqv.2	+	3	286	c.225C>T	c.(223-225)CTC>CTT	p.L75L	FAM91A1_uc011lik.1_Silent_p.L75L|FAM91A1_uc011lil.1_5'UTR	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	75										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GAGATCATCTCATGCTGTACC	0.388													0	0	0	0.005524	0	35	39										T	124787454	C	T	124787454	2	4	98	1	0	0	0	0	0	0	0	1	5651	813	29	1		1	FAM91A1	8	124787454	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	53816530	124787454	21576568	46	30074										
MPDZ	8777	broad.mit.edu	37	chr9	13121876	13121876	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gcactctctgtggcgtctgtCtcaggacattgattgcttca	10	11	4	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:13121876C>G	uc010mia.1	-	37	5150	c.5093G>C	c.(5092-5094)AGA>ACA	p.R1698T	MPDZ_uc003zkx.3_5'Flank|MPDZ_uc003zky.3_Missense_Mutation_p.R232T|MPDZ_uc010mib.2_Missense_Mutation_p.R403T|MPDZ_uc010mhx.2_Missense_Mutation_p.R520T|MPDZ_uc011lmm.1_Missense_Mutation_p.R557T|MPDZ_uc003zkz.3_Missense_Mutation_p.R391T|MPDZ_uc010mhy.2_Missense_Mutation_p.R1698T|MPDZ_uc010mhz.2_Missense_Mutation_p.R1665T|MPDZ_uc011lmn.1_Missense_Mutation_p.R1665T|MPDZ_uc003zlb.3_Missense_Mutation_p.R1698T	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1698	PDZ 10.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TGGCGTCTGTCTCAGGACATT	0.473													0	0	0	0.010729	0	11	2										G	13121876	C	G	13121876	3	3	98	1	0	0	0	0	1	0	0	0	9722	913	32	1	1068	1	MPDZ	9	13121876	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		13121876	128091555	47	30075										
NTRK2	4915	broad.mit.edu	37	chr9	87366903	87366903	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ctcccttcctttctctaggtCtatgctgtggtggtgattgc	10	11	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:87366903C>A	uc004aoa.1	+	14	2237	c.1299C>A	c.(1297-1299)GTC>GTA	p.V433V	NTRK2_uc004anv.1_Silent_p.V420V|NTRK2_uc004any.1_Silent_p.V433V|NTRK2_uc004anz.1_Silent_p.V433V|NTRK2_uc011lsz.1_Silent_p.V433V|NTRK2_uc011lta.1_Silent_p.V433V|NTRK2_uc004aob.1_Silent_p.V433V|NTRK2_uc011ltb.1_Silent_p.V277V|NTRK2_uc004aoc.2_5'UTR	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	433	Helical; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TTCTCTAGGTCTATGCTGTGG	0.368										TSP Lung(25;0.17)			1	0	8.73648e-17	0.019004	1.09576e-16	29	35										A	87366903	C	A	87366903	2	1	98	1	0	0	0	0	0	0	0	1	10707	900	32	3		3	NTRK2	9	87366903	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	74245027	87366903	53846528	48	30076										
PTCH1	5727	broad.mit.edu	37	chr9	98209683	98209683	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gaccctgagtccaggtggggCtgctgtctcgggttcgaggg	18	10	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:98209683C>A	uc004avk.3	-	23	4043	c.3855G>T	c.(3853-3855)CAG>CAT	p.Q1285H	PTCH1_uc010mrn.2_Missense_Mutation_p.Q77H|PTCH1_uc010mro.2_Missense_Mutation_p.Q1134H|PTCH1_uc010mrp.2_Missense_Mutation_p.Q1134H|PTCH1_uc010mrq.2_Missense_Mutation_p.Q1134H|PTCH1_uc004avl.3_Missense_Mutation_p.Q1134H|PTCH1_uc010mrr.2_Missense_Mutation_p.Q1219H|PTCH1_uc004avm.3_Missense_Mutation_p.Q1284H	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1285	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CCAGGTGGGGCTGCTGTCTCG	0.677									Basal_Cell_Nevus_syndrome				1	0	1.49228e-48	0.01441	2.32482e-48	76	85										A	98209683	C	A	98209683	3	1	98	1	0	0	0	0	1	0	0	0	12730	796	28	4	492	4	PTCH1	9	98209683	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	10842780	98209683	43003748	49	30077										
OR1Q1	158131	broad.mit.edu	37	chr9	125377931	125377931	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggaggcttcatgaaatggatGagcagaatgcagactttttt	12	5	1	4	rs112809062		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:125377931G>A	uc011lyy.1	+	1	915	c.915G>A	c.(913-915)ATG>ATA	p.M305I		NM_012364	NP_036496	Q15612	OR1Q1_HUMAN	olfactory receptor, family 1, subfamily Q,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAAATGGATGAGCAGAATGC	0.443													0	0	0	0.021022	0	32	24										A	125377931	G	A	125377931	3	1	98	1	0	0	0	0	1	0	0	0	10971	1290	45	1	917	1	OR1Q1	9	125377931	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	27168248	125377931	15835500	50	30078										
ZBTB43	23099	broad.mit.edu	37	chr9	129595162	129595162	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atgcactgaagttttagaggGaaaccctacagtcctttgtc	9	9	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr9:129595162G>A	uc004bql.2	+	3	647	c.374G>A	c.(373-375)GGA>GAA	p.G125E	ZBTB43_uc010mxf.2_Missense_Mutation_p.G125E	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTTTTAGAGGGAAACCCTACA	0.483													0	0	0	0.00499	0	15	24										A	129595162	G	A	129595162	3	1	98	1	0	0	0	0	1	0	0	0	17541	1174	41	1	376	1	ZBTB43	9	129595162	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	4217231	129595162	11618269	51	30079										
ANKRD30A	91074	broad.mit.edu	37	chr10	37430754	37430754	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgatgaggctgcacccttggTggaaagaacacctgacacgg	13	10	0	4			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:37430754T>C	uc001iza.1	+	7	860	c.761T>C	c.(760-762)GTG>GCG	p.V254A		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	310						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GCACCCTTGGTGGAAAGAACA	0.502													0	0	0	0.004672	0	3	50										C	37430754	T	C	37430754	3	2	98	1	0	0	0	0	1	0	0	0	658	1696	59	5	787	5	ANKRD30A	10	37430754	Missense_Mutation	SNP	T	TCGA-G2-A3IB-01A-11D-A20D-08		37430754	98103993	52	30080										
GPRIN2	9721	broad.mit.edu	37	chr10	46999113	46999113	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	catgaagccagcacgggcctCtggccccaaggcgcgaccca	12	17	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:46999113C>T	uc001jec.2	+	3	368	c.233C>T	c.(232-234)TCT>TTT	p.S78F	GPRIN2_uc010qfq.1_5'Flank	NM_014696	NP_055511	O60269	GRIN2_HUMAN	G protein-regulated inducer of neurite outgrowth	78											0						GCACGGGCCTCTGGCCCCAAG	0.701													0	0	0	0.008291	0	7	48										T	46999113	C	T	46999113	3	4	98	1	0	0	0	0	1	0	0	0	6730	913	32	1	235	1	GPRIN2	10	46999113	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	9568359	46999113	88535634	53	30081										
MYST4	23522	broad.mit.edu	37	chr10	76603021	76603021	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tagagaagtatctcagaagtCaaagtgatctcacaagcacc	8	9	3	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:76603021C>G	uc001jwn.1	+	3	899	c.406C>G	c.(406-408)CAA>GAA	p.Q136E	MYST4_uc001jwm.1_Missense_Mutation_p.Q136E|MYST4_uc001jwo.1_Missense_Mutation_p.Q136E|MYST4_uc001jwp.1_Missense_Mutation_p.Q136E	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	136	H15.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					TCTCAGAAGTCAAAGTGATCT	0.498			T	CREBBP	AML								0	0	0	0.00632	0	29	22										G	76603021	C	G	76603021	3	3	98	1	0	0	0	0	1	0	0	0	10105	827	29	1	408	1	MYST4	10	76603021	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	29603908	76603021	58931726	54	30082										
BTAF1	9044	broad.mit.edu	37	chr10	93751881	93751881	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cttttttcttattaggatccAcctcagaaaaagatggaatg	7	7	2	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:93751881A>G	uc001khr.2	+	21	2958	c.2860A>G	c.(2860-2862)ACC>GCC	p.T954A	BTAF1_uc001kht.1_Missense_Mutation_p.T392A	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	954					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				ATTAGGATCCACCTCAGAAAA	0.358													0	0	0	0.020292	0	14	27										G	93751881	A	G	93751881	3	3	98	1	0	0	0	0	1	0	0	0	1536	159	6	5	2942	5	BTAF1	10	93751881	Missense_Mutation	SNP	A	TCGA-G2-A3IB-01A-11D-A20D-08	17148860	93751881	41782866	55	30083										
PNLIPRP3	119548	broad.mit.edu	37	chr10	118228730	118228730	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tttgttccaaagaaggttgcCcaacaatgggtcattttgct	9	8	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr10:118228730C>A	uc001lcl.3	+	9	1062	c.961C>A	c.(961-963)CCA>ACA	p.P321T		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	321					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AGAAGGTTGCCCAACAATGGG	0.358													1	0	1.22574e-08	0.014323	1.37431e-08	18	19										A	118228730	C	A	118228730	3	1	98	1	0	0	0	0	1	0	0	0	12152	623	22	4	995	4	PNLIPRP3	10	118228730	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	24476849	118228730	17306017	56	30084										
NLRP6	171389	broad.mit.edu	37	chr11	281667	281667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgtgccggttcccggagctgGcgctgcagcgagtgcgcttc	16	13	0	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:281667G>A	uc010qvs.1	+	4	1933	c.1933G>A	c.(1933-1935)GCG>ACG	p.A645T	NLRP6_uc010qvt.1_Missense_Mutation_p.A645T	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	645						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCCGGAGCTGGCGCTGCAGCG	0.647													0	0	0	0.01441	0	83	93										A	281667	G	A	281667	3	1	98	1	0	0	0	0	1	0	0	0	10481	1203	42	2	1947	2	NLRP6	11	281667	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		281667	134724849	57	30085										
NUP98	4928	broad.mit.edu	37	chr11	3744407	3744407	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ctgctgggtgcatatggtaaGaattattttctatttcttct	8	6	3	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:3744407G>C	uc001lyh.2	-	16	2417	c.2126C>G	c.(2125-2127)TCT>TGT	p.S709C	NUP98_uc001lyi.2_Missense_Mutation_p.S709C|NUP98_uc001lyj.1_Missense_Mutation_p.S709C|NUP98_uc001lyk.1_Missense_Mutation_p.S726C	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	726					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CATATGGTAAGAATTATTTTC	0.423			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.021022	0	32	50										C	3744407	G	C	3744407	3	2	98	1	0	0	0	0	1	0	0	0	10773	942	33	1	3369	1	NUP98	11	3744407	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	3462740	3744407	131262109	58	30086										
SBF2	81846	broad.mit.edu	37	chr11	9812207	9812207	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tccttttttggcatgcttttCtcctttatcatcaaataaag	4	9	3	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:9812207C>G	uc001mib.2	-	34	4732	c.4594G>C	c.(4594-4596)GAA>CAA	p.E1532Q	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.E176Q|SBF2_uc001mic.2_5'Flank|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1532	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		GCATGCTTTTCTCCTTTATCA	0.308													0	0	0	0.010771	0	33	54										G	9812207	C	G	9812207	3	3	98	1	0	0	0	0	1	0	0	0	13859	922	32	1	983	1	SBF2	11	9812207	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	6067800	9812207	125194309	59	30087										
OR4A5	81318	broad.mit.edu	37	chr11	51411647	51411647	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	taacatatatgaaaatacagGgtacaaaaaagaggacaaca	7	5	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:51411647G>T	uc001nhi.1	-	1	749	c.749C>A	c.(748-750)CCC>CAC	p.P250H		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GAAAATACAGGGTACAAAAAA	0.398													1	0	8.04996e-18	0.012319	1.02706e-17	19	31										T	51411647	G	T	51411647	3	4	98	1	0	0	0	0	1	0	0	0	11043	1232	43	4	202	4	OR4A5	11	51411647	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	41599440	51411647	83594869	60	30088										
OR4C15	81309	broad.mit.edu	37	chr11	55322491	55322491	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ttatgtgtgacttgtacccgTtactggagcttgcctgcact	10	10	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:55322491T>C	uc010rig.1	+	1	709	c.709T>C	c.(709-711)TTA>CTA	p.L237L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTGTACCCGTTACTGGAGCT	0.448										HNSCC(20;0.049)			0	0	0	0.020292	0	14	11										C	55322491	T	C	55322491	2	2	98	1	0	0	0	0	0	0	0	1	11048	1722	60	5		5	OR4C15	11	55322491	Silent	SNP	T	TCGA-G2-A3IB-01A-11D-A20D-08	3910844	55322491	79684025	61	30089										
OR10Q1	219960	broad.mit.edu	37	chr11	57996150	57996150	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aggaaagacaggttggacagGaagaaatacatcggggtgcg	16	5	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:57996150G>A	uc010rkd.1	-	1	198	c.198C>T	c.(196-198)TTC>TTT	p.F66F		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				GGTTGGACAGGAAGAAATACA	0.532													0	0	0	0.007835	0	33	67										A	57996150	G	A	57996150	2	1	98	1	0	0	0	0	0	0	0	1	10916	1165	41	1		1	OR10Q1	11	57996150	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	2673659	57996150	77010366	62	30090										
MS4A1	931	broad.mit.edu	37	chr11	60229778	60229778	+	Translation_Start_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atgcatgacacaaggtaagaCtgccaaaaatcttgttcttg	8	8	2	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr11:60229778C>A	uc001npp.2	+	3	347	c.-69C>A	c.(-71--67)GACTG>GAATG		MS4A1_uc009ymy.1_Intron|MS4A1_uc001npq.2_Intron|MS4A1_uc009yna.2_Translation_Start_Site|MS4A1_uc009ymz.2_Intron|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member						B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	CAAGGTAAGACTGCCAAAAAT	0.408													1	0	0.004672	0.004672	0.00483536	3	11										A	60229778	C	A	60229778	1	1	98	1	0	0	0	0	0	0	0	0	9854	580	20	4		4	MS4A1	11	60229778	Translation_Start_Site	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	2233628	60229778	74776738	63	30091										
A2M	2	broad.mit.edu	37	chr12	9262584	9262584	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gaaaattgcttgaggccaccCtctaactggaaactctgcca	8	12	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:9262584C>A	uc001qvk.1	-	6	665	c.552G>T	c.(550-552)GAG>GAT	p.E184D	A2M_uc009zgk.1_Missense_Mutation_p.E34D	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	184					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TGAGGCCACCCTCTAACTGGA	0.463													1	0	1.57945e-13	0.011902	1.90048e-13	37	54										A	9262584	C	A	9262584	3	1	98	1	0	0	0	0	1	0	0	0	4	680	24	4	3996	4	A2M	12	9262584	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		9262584	124589311	64	30092										
MLL2	8085	broad.mit.edu	37	chr12	49420342	49420343	+	Frame_Shift_Ins	INS	-	-	GC													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	acagggccccttgatcttatINSgcattggacacagcatggtc							TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			-	GC	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:49420342_49420343insGC	uc001rta.3	-	48	15406_15407	c.15406_15407insGC	c.(15406-15408)CATfs	p.H5136fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5136	RING-type 4; degenerate.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTTGATCTTATGCATTGGACAC	0.52			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								53	76	---	---								GC	49420343	-	GC	49420342	7	5	98	1	0	1	1	0	0	0	0	0	9621	1464	51	0	1234	0	MLL2	12	49420342	Frame_Shift_Ins	INS	-	TCGA-G2-A3IB-01A-11D-A20D-08	40157758	49420342	84431553	65	30093										
KRT84	3890	broad.mit.edu	37	chr12	52771821	52771822	+	Frame_Shift_Ins	INS	-	-	TA													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gtctggggctgggctctcagINStacttggtccggcaggaggt							TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:52771821_52771822insTA	uc001sah.1	-	9	1847_1848	c.1799_1800insTA	c.(1798-1800)TACfs	p.Y600fs		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	600	Tail.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGGCTCTCAGTACTTGGTCCG	0.688																		4	7	---	---								TA	52771822	-	TA	52771821	7	5	98	1	0	1	1	0	0	0	0	0	8498	1024	36	0	6	0	KRT84	12	52771821	Frame_Shift_Ins	INS	-	TCGA-G2-A3IB-01A-11D-A20D-08	3351479	52771821	81080074	66	30094										
LHX5	64211	broad.mit.edu	37	chr12	113906970	113906970	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aggctggatgagctcaggtaGtcgtctttgcacacgaactt	12	9	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr12:113906970G>T	uc001tvj.1	-	2	928	c.354C>A	c.(352-354)GAC>GAA	p.D118E		NM_022363	NP_071758	Q9H2C1	LHX5_HUMAN	LIM homeobox protein 5	118	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCTCAGGTAGTCGTCTTTGC	0.572													1	0	3.86212e-05	0.008291	4.14198e-05	11	13										T	113906970	G	T	113906970	3	4	98	1	0	0	0	0	1	0	0	0	8774	1020	36	4	870	4	LHX5	12	113906970	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	61135149	113906970	19944925	67	30095										
C1QTNF9	338872	broad.mit.edu	37	chr13	24895231	24895231	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aaggggcttgcagggcccatGggagagaagggcctccgagg	19	9	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr13:24895231G>T	uc001upj.2	+	4	388	c.327G>T	c.(325-327)ATG>ATT	p.M109I	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	109	Collagen-like 2.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		CAGGGCCCATGGGAGAGAAGG	0.582													1	0	3.51602e-12	0.008871	4.0974e-12	20	19										T	24895231	G	T	24895231	3	4	98	1	0	0	0	0	1	0	0	0	1970	1348	47	4	337	4	C1QTNF9	13	24895231	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		24895231	90274647	68	30096										
PCDH20	64881	broad.mit.edu	37	chr13	61986716	61986716	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	agagttccaagccaccacagCtacttcatagaactgctgta	7	12	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr13:61986716C>A	uc001vid.3	-	2	1880	c.1516G>T	c.(1516-1518)GCT>TCT	p.A506S	PCDH20_uc010thj.1_Missense_Mutation_p.A506S	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	479	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GCCACCACAGCTACTTCATAG	0.388													1	0	9.61239e-26	0.01441	1.35489e-25	63	78										A	61986716	C	A	61986716	3	1	98	1	0	0	0	0	1	0	0	0	11515	797	28	4	1343	4	PCDH20	13	61986716	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	37091485	61986716	53183162	69	30097										
COCH	1690	broad.mit.edu	37	chr14	31349663	31349663	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	catcttttatttcaggtaaaCgactaaagaaaacacccgag	6	9	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:31349663C>T	uc001wqr.2	+	7	522	c.442C>T	c.(442-444)CGA>TGA	p.R148*	COCH_uc001wqp.2_Nonsense_Mutation_p.R148*|COCH_uc001wqq.3_Nonsense_Mutation_p.R148*|uc001wqs.2_Intron|COCH_uc001wqt.1_Translation_Start_Site	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	148					sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TTCAGGTAAACGACTAAAGAA	0.413													0	0	0	0.010729	0	8	12										T	31349663	C	T	31349663	4	4	98	1	0	0	0	0	0	1	0	0	3656	528	19	2	464	2	COCH	14	31349663	Nonsense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		31349663	75999877	70	30098										
FAM71D	161142	broad.mit.edu	37	chr14	67671305	67671305	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gtgcatgatgcggagaacatGagcctgaaagtaaagctggt	14	6	0	4			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:67671305G>A	uc001xja.1	+	5	665	c.411G>A	c.(409-411)ATG>ATA	p.M137I	FAM71D_uc010aqn.1_RNA	NM_173526	NP_775797	Q8N9W8	FA71D_HUMAN	hypothetical protein LOC161142	137										ovary(1)	1		all_hematologic(31;0.0116)		all cancers(60;0.00107)|BRCA - Breast invasive adenocarcinoma(234;0.00993)|OV - Ovarian serous cystadenocarcinoma(108;0.012)		CGGAGAACATGAGCCTGAAAG	0.493													0	0	0	0.001168	0	4	15										A	67671305	G	A	67671305	3	1	98	1	0	0	0	0	1	0	0	0	5610	1290	45	1	421	1	FAM71D	14	67671305	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	36321642	67671305	39678235	71	30099										
ZFYVE1	53349	broad.mit.edu	37	chr14	73459948	73459948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gccgaagcccagaaaagtccGtgggagggttgtaagtcctc	14	10	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:73459948G>A	uc001xnm.2	-	4	1746	c.1106C>T	c.(1105-1107)ACG>ATG	p.T369M	ZFYVE1_uc010arj.2_Missense_Mutation_p.T369M	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	369						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		AGAAAAGTCCGTGGGAGGGTT	0.562													0	0	0	0.01441	0	47	50										A	73459948	G	A	73459948	3	1	98	1	0	0	0	0	1	0	0	0	17660	1145	40	2	1263	2	ZFYVE1	14	73459948	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	5788643	73459948	33889592	72	30100										
PTPN21	11099	broad.mit.edu	37	chr14	88983603	88983603	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	taccagaggctgaagtaagtGacctggaaagacagaaggtc	13	7	0	5			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:88983603G>A	uc001xwv.3	-	3	514	c.183C>T	c.(181-183)GTC>GTT	p.V61V	PTPN21_uc010twc.1_5'UTR|PTPN21_uc010atf.1_Silent_p.V61V	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	61	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TGAAGTAAGTGACCTGGAAAG	0.433													0	0	0	0.006122	0	14	52										A	88983603	G	A	88983603	2	1	98	1	0	0	0	0	0	0	0	1	12786	1277	45	1		1	PTPN21	14	88983603	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	15523655	88983603	18365937	73	30101										
DIO3	1735	broad.mit.edu	37	chr14	102028171	102028171	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ccgcctgtgcaccctggcgtCgctcaaggcggtgtggcatg	15	14	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:102028171C>T	uc010txq.1	+	1	484	c.260C>T	c.(259-261)TCG>TTG	p.S87L	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	87	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				ACCCTGGCGTCGCTCAAGGCG	0.662													0	0	0	0.001984	0	6	73										T	102028171	C	T	102028171	3	4	98	1	0	0	0	0	1	0	0	0	4526	893	31	1	340	1	DIO3	14	102028171	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	13044568	102028171	5321369	74	30102										
PPP1R13B	23368	broad.mit.edu	37	chr14	104206397	104206397	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	attggcatctgatgacggggCaggctcagcggggagtgggg	20	7	2	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr14:104206397C>A	uc001yof.1	-	12	2639	c.2356G>T	c.(2356-2358)GCC>TCC	p.A786S	PPP1R13B_uc010awv.1_RNA|PPP1R13B_uc001yog.1_Missense_Mutation_p.A653S	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	786	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GATGACGGGGCAGGCTCAGCG	0.602													1	0	1.4709e-25	0.01441	2.05371e-25	44	83										A	104206397	C	A	104206397	3	1	98	1	0	0	0	0	1	0	0	0	12357	710	25	4	940	4	PPP1R13B	14	104206397	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	2178226	104206397	3143143	75	30103										
VPS39	23339	broad.mit.edu	37	chr15	42454656	42454656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atgctggggggcgacaggtaCatccgaagcagggacagata	16	8	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:42454656C>T	uc001zpd.2	-	23	2383	c.2232G>A	c.(2230-2232)ATG>ATA	p.M744I	VPS39_uc001zpc.2_Missense_Mutation_p.M733I|VPS39_uc001zpb.2_Missense_Mutation_p.M79I	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	744					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		GCGACAGGTACATCCGAAGCA	0.592													0	0	0	0.016723	0	12	44										T	42454656	C	T	42454656	3	4	98	1	0	0	0	0	1	0	0	0	17206	478	17	2	444	2	VPS39	15	42454656	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		42454656	60076736	76	30104										
HDC	3067	broad.mit.edu	37	chr15	50557790	50557791	+	Frame_Shift_Del	DEL	CT	CT	-													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cagggatgcccgttgctcacCtctctctctgtactcctcag							TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:50557790_50557791delCT	uc001zxz.2	-	1	136_137	c.30_31delAG	c.(28-33)AGAGGGfs	p.R10fs	HDC_uc010uff.1_Frame_Shift_Del_p.R10fs|HDC_uc010bet.1_Frame_Shift_Del_p.R10fs|HDC_uc010beu.1_Frame_Shift_Del_p.R10fs	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	10_11					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CGTTGCTCACCTCTCTCTCTGT	0.599																		8	80	---	---								-	50557791	CT	-	50557790	7	5	98	1	0	1	0	1	0	0	0	0	7015	695	24	0	2005	0	HDC	15	50557790	Frame_Shift_Del	DEL	CT	TCGA-G2-A3IB-01A-11D-A20D-08	8103134	50557790	51973602	77	30105										
DMXL2	23312	broad.mit.edu	37	chr15	51741202	51741202	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tatagaatgtcaagaattctGttagggatgttaaaagcatt	9	3	2	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:51741202G>T	uc002abf.2	-	43	9315	c.9090C>A	c.(9088-9090)AAC>AAA	p.N3030K	DMXL2_uc002abd.2_Missense_Mutation_p.N1122K|DMXL2_uc010ufy.1_Missense_Mutation_p.N3031K|DMXL2_uc010bfa.2_Missense_Mutation_p.N2394K|DMXL2_uc002abc.2_RNA	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	3030	WD 16.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CAAGAATTCTGTTAGGGATGT	0.408													1	0	2.74318e-10	0.006214	3.123e-10	8	22										T	51741202	G	T	51741202	3	4	98	1	0	0	0	0	1	0	0	0	4595	1368	48	4	24	4	DMXL2	15	51741202	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	1183412	51741202	50790190	78	30106										
SLC24A1	9187	broad.mit.edu	37	chr15	65918083	65918083	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gagatcctcaacctcacctgGtggcccttattccgtgatgt	9	13	2	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:65918083G>T	uc010ujf.1	+	2	1952	c.1665G>T	c.(1663-1665)TGG>TGT	p.W555C	SLC24A1_uc010ujd.1_Missense_Mutation_p.W555C|SLC24A1_uc010uje.1_Missense_Mutation_p.W555C|SLC24A1_uc010ujg.1_Missense_Mutation_p.W555C|SLC24A1_uc010ujh.1_Missense_Mutation_p.W555C	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	555	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						ACCTCACCTGGTGGCCCTTAT	0.522													1	0	1.21353e-23	0.01441	1.66299e-23	47	65										T	65918083	G	T	65918083	3	4	98	1	0	0	0	0	1	0	0	0	14465	1270	44	4		4	SLC24A1	15	65918083	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	14176881	65918083	36613309	79	30107										
CHRNB4	1143	broad.mit.edu	37	chr15	78922018	78922018	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggtcttgtgggttcactgtcCttctccctgggagggccact	13	12	3	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr15:78922018C>A	uc002bed.1	-	5	741	c.629G>T	c.(628-630)AGG>ATG	p.R210M	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.R28M	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	210	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						GTTCACTGTCCTTCTCCCTGG	0.552													1	0	1.22047e-21	0.01441	1.62729e-21	67	100										A	78922018	C	A	78922018	3	1	98	1	0	0	0	0	1	0	0	0	3393	681	24	4	875	4	CHRNB4	15	78922018	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	13003935	78922018	23609374	80	30108										
ZNF598	90850	broad.mit.edu	37	chr16	2049881	2049883	+	In_Frame_Del	DEL	CGT	CGT	-													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ctcctgcagggccgggccgcCgtcctcctcctcctcctgtg					rs141374045	by1000genomes	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:2049881_2049883delCGT	uc002cof.1	-	11	1682_1684	c.1667_1669delACG	c.(1666-1671)GACGGC>GGC	p.D556del	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	556						intracellular	zinc ion binding			lung(1)|breast(1)	2						GCCGGGCCGCCGTCCTCCTCCTC	0.7																		2	4	---	---								-	2049883	CGT	-	2049881	7	5	98	1	0	1	0	1	0	0	0	0	18025	652	23	0	1061	0	ZNF598	16	2049881	In_Frame_Del	DEL	CGT	TCGA-G2-A3IB-01A-11D-A20D-08		2049881	88304872	81	30109										
GP2	2813	broad.mit.edu	37	chr16	20322574	20322574	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ccaagccaggaggacagtcaGgaggaccataggccaggcca	14	12	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:20322574G>T	uc002dgv.2	-	12	1668	c.1585C>A	c.(1585-1587)CTG>ATG	p.L529M	GP2_uc002dgw.2_Missense_Mutation_p.L526M|GP2_uc002dgx.2_Missense_Mutation_p.L382M|GP2_uc002dgy.2_Missense_Mutation_p.L379M	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	529						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						AGGACAGTCAGGAGGACCATA	0.522													1	0	8.30282e-39	0.01441	1.26682e-38	38	48										T	20322574	G	T	20322574	3	4	98	1	0	0	0	0	1	0	0	0	6582	991	35	4	32	4	GP2	16	20322574	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	18272693	20322574	70032179	82	30110										
ZNF267	10308	broad.mit.edu	37	chr16	31927534	31927534	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tacacatcagagaagtcataCtggagagagaccctacaaat	8	9	2	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:31927534C>G	uc002ecs.3	+	4	2173	c.1964C>G	c.(1963-1965)ACT>AGT	p.T655S		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	655					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AGAAGTCATACTGGAGAGAGA	0.453													0	0	0	0.004672	0	3	86										G	31927534	C	G	31927534	3	3	98	1	0	0	0	0	1	0	0	0	17803	565	20	4	1978	4	ZNF267	16	31927534	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	11604960	31927534	58427219	83	30111										
RPGRIP1L	23322	broad.mit.edu	37	chr16	53730066	53730066	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aagctttttatcataaccttTtaattttatcctcctgcttg	3	9	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:53730066T>A	uc002ehp.2	-	3	291	c.227A>T	c.(226-228)AAA>ATA	p.K76I	RPGRIP1L_uc002eho.3_Missense_Mutation_p.K76I|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.K76I|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.K76I|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.K76I|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.K76I|RPGRIP1L_uc010cby.1_Missense_Mutation_p.K76I	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	76	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TCATAACCTTTTAATTTTATC	0.323													0	0	0	0.021022	0	31	47										A	53730066	T	A	53730066	3	1	98	1	0	0	0	0	1	0	0	0	13550	1841	64	5	3820	5	RPGRIP1L	16	53730066	Missense_Mutation	SNP	T	TCGA-G2-A3IB-01A-11D-A20D-08	21802532	53730066	36624687	84	30112										
CDYL2	124359	broad.mit.edu	37	chr16	80646693	80646693	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cggcccattgatggccaccaCgataggcttcttaaactgga	10	12	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr16:80646693C>T	uc002ffs.2	-	5	1153	c.1048G>A	c.(1048-1050)GTG>ATG	p.V350M		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	350						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						ATGGCCACCACGATAGGCTTC	0.562													0	0	0	0.012213	0	27	55										T	80646693	C	T	80646693	3	4	98	1	0	0	0	0	1	0	0	0	3186	536	19	2	484	2	CDYL2	16	80646693	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	26916627	80646693	9708060	85	30113										
TP53	7157	broad.mit.edu	37	chr17	7576855	7576855	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggtcccaagacttagtacctGaagggtgaaatattctccat	9	9	1	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:7576855G>A	uc002gim.2	-	9	1185	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.Q331*|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Nonsense_Mutation_p.Q199*|TP53_uc010cng.1_Nonsense_Mutation_p.Q199*|TP53_uc002gii.1_Nonsense_Mutation_p.Q199*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q331*|TP53_uc010cni.1_Nonsense_Mutation_p.Q331*|TP53_uc002gij.2_Nonsense_Mutation_p.Q331*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	331	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		Q -> R (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q331*(14)|p.0?(7)|p.Q331P(3)|p.Q331fs*6(1)|p.?(1)|p.Q331Q(1)|p.Q331R(1)|p.Q331H(1)|p.Q331fs*14(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTAGTACCTGAAGGGTGAAA	0.448		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.008361	0	26	44										A	7576855	G	A	7576855	4	1	98	1	0	0	0	0	0	1	0	0	16378	1299	45	1	291	1	TP53	17	7576855	Nonsense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		7576855	73618355	86	30114										
TP53	7157	broad.mit.edu	37	chr17	7578403	7578403	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	agcagcgctcatggtgggggCagcgcctcacaacctccgtc	13	15	2	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:7578403C>A	uc002gim.2	-	5	721	c.527G>T	c.(526-528)TGC>TTC	p.C176F	TP53_uc002gig.1_Missense_Mutation_p.C176F|TP53_uc002gih.2_Missense_Mutation_p.C176F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C44F|TP53_uc010cng.1_Missense_Mutation_p.C44F|TP53_uc002gii.1_Missense_Mutation_p.C44F|TP53_uc010cnh.1_Missense_Mutation_p.C176F|TP53_uc010cni.1_Missense_Mutation_p.C176F|TP53_uc002gij.2_Missense_Mutation_p.C176F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C83F|TP53_uc002gio.2_Missense_Mutation_p.C44F|TP53_uc010vug.1_Missense_Mutation_p.C137F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	176	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	CP -> FS (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C176F(102)|p.C176Y(56)|p.C176S(19)|p.C176W(11)|p.C176R(8)|p.C176fs*71(7)|p.0?(7)|p.C176*(6)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.C176G(3)|p.C176fs*5(3)|p.R175_E180delRCPHHE(3)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.C44Y(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R42fs*24(1)|p.C83Y(1)|p.C176fs*72(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R174fs*70(1)|p.C176del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.C176fs*6(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGTGGGGGCAGCGCCTCAC	0.652		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	1.8453e-21	0.010771	2.43843e-21	31	32										A	7578403	C	A	7578403	3	1	98	1	0	0	0	0	1	0	0	0	16378	710	25	4	771	4	TP53	17	7578403	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	1548	7578403	73616807	87	30115										
DNAH9	1770	broad.mit.edu	37	chr17	11584169	11584169	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ccttcgatgcagaacagcagCaattctgggagcaattccac	9	12	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:11584169C>A	uc002gne.2	+	19	3774	c.3706C>A	c.(3706-3708)CAA>AAA	p.Q1236K	DNAH9_uc010coo.2_Missense_Mutation_p.Q530K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1236	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGAACAGCAGCAATTCTGGGA	0.527													1	0	0.000978159	0.010729	0.00101949	10	17										A	11584169	C	A	11584169	3	1	98	1	0	0	0	0	1	0	0	0	4608	711	25	4	3780	4	DNAH9	17	11584169	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	4005766	11584169	69611041	88	30116										
TOP2A	7153	broad.mit.edu	37	chr17	38564286	38564286	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggaaaaccccatatttgtctCtcccaaccacaccaaggcct	5	16	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:38564286C>G	uc002huq.2	-	12	1559	c.1433G>C	c.(1432-1434)AGA>ACA	p.R478T	TOP2A_uc002hur.1_Missense_Mutation_p.R119T	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	478					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	ATATTTGTCTCTCCCAACCAC	0.428													0	0	0	0.014323	0	19	37										G	38564286	C	G	38564286	3	3	98	1	0	0	0	0	1	0	0	0	16362	913	32	1	3258	1	TOP2A	17	38564286	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	26980117	38564286	42630924	89	30117										
EME1	146956	broad.mit.edu	37	chr17	48452831	48452831	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggttgctaagcagtgaaagtGaagatgaagaagaatttatt	12	2	0	6			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:48452831G>T	uc002iqs.1	+	2	335	c.262G>T	c.(262-264)GAA>TAA	p.E88*	MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_Nonsense_Mutation_p.E88*	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1	88					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			CAGTGAAAGTGAAGATGAAGA	0.463								Direct_reversal_of_damage|Homologous_recombination					1	0	8.86878e-18	0.01441	1.12186e-17	37	53										T	48452831	G	T	48452831	4	4	98	1	0	0	0	0	0	1	0	0	5088	1291	45	3	264	3	EME1	17	48452831	Nonsense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	9888545	48452831	32742379	90	30118										
USP32	84669	broad.mit.edu	37	chr17	58268030	58268030	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cttccccacaatcaattttaCagcctctgcaaaatctaaaa	2	13	3	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:58268030C>A	uc002iyo.1	-	29	3822	c.3536G>T	c.(3535-3537)TGT>TTT	p.C1179F	USP32_uc002iyn.1_Missense_Mutation_p.C849F	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1179					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ATCAATTTTACAGCCTCTGCA	0.393													1	0	2.77807e-22	0.013114	3.73777e-22	39	55										A	58268030	C	A	58268030	3	1	98	1	0	0	0	0	1	0	0	0	17060	478	17	4	1302	4	USP32	17	58268030	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	9815199	58268030	22927180	91	30119										
SDK2	54549	broad.mit.edu	37	chr17	71390398	71390398	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	agcctcggggacctcgctccAgcgcaccagcatgctgctgg	13	16	0	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:71390398A>G	uc010dfm.2	-	26	3658	c.3658T>C	c.(3658-3660)TGG>CGG	p.W1220R	SDK2_uc002jjt.3_Missense_Mutation_p.W379R|SDK2_uc010dfn.2_Missense_Mutation_p.W899R	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1220	Fibronectin type-III 7.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						ACCTCGCTCCAGCGCACCAGC	0.652													0	0	0	0.012319	0	16	16										G	71390398	A	G	71390398	3	3	98	1	0	0	0	0	1	0	0	0	13969	188	7	5	2940	5	SDK2	17	71390398	Missense_Mutation	SNP	A	TCGA-G2-A3IB-01A-11D-A20D-08	13122368	71390398	9804812	92	30120										
GRIN2C	2905	broad.mit.edu	37	chr17	72839417	72839418	+	Frame_Shift_Ins	INS	-	-	G													0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	agcccgtggggctcggctctINSgggggcgggtcgggggtggg							TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:72839417_72839418insG	uc002jlt.1	-	13	3014_3015	c.2858_2859insC	c.(2857-2859)CCAfs	p.P953fs	GRIN2C_uc010wrh.1_RNA	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	953	Cytoplasmic (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GGCTCGGCTCTGGGGGCGGGTC	0.663																		2	4	---	---								G	72839418	-	G	72839417	7	5	98	1	0	1	1	0	0	0	0	0	6781	1567	55	0	846	0	GRIN2C	17	72839417	Frame_Shift_Ins	INS	-	TCGA-G2-A3IB-01A-11D-A20D-08	1449019	72839417	8355793	93	30121										
ARHGDIA	396	broad.mit.edu	37	chr17	79826899	79826899	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tccacgggggtcaggaactcGtactcctcggcccggggccc	14	16	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr17:79826899G>A	uc002kbp.2	-	5	507	c.468C>T	c.(466-468)TAC>TAT	p.Y156Y	ARHGDIA_uc002kjk.1_Silent_p.Y31Y|ARHGDIA_uc002kbq.2_Silent_p.Y156Y|ARHGDIA_uc002kbr.2_Intron|ARHGDIA_uc002kbs.1_Intron|ARHGDIA_uc002kbt.1_Silent_p.Y156Y|ARHGDIA_uc010dig.1_RNA	NM_004309	NP_004300	P52565	GDIR1_HUMAN	Rho GDP dissociation inhibitor (GDI) alpha	156					anti-apoptosis|cellular component movement|negative regulation of axonogenesis|negative regulation of cell adhesion|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoskeleton|cytosol	GTPase activator activity|identical protein binding|Rho GDP-dissociation inhibitor activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TCAGGAACTCGTACTCCTCGG	0.652													0	0	0	0.021523	0	21	24										A	79826899	G	A	79826899	2	1	98	1	0	0	0	0	0	0	0	1	890	1140	40	2		2	ARHGDIA	17	79826899	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	6987482	79826899	1368311	94	30122										
NPC1	4864	broad.mit.edu	37	chr18	21119389	21119389	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gactgtggcttcacccagtcGaaataatcgtcgatccagga	10	11	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr18:21119389G>A	uc002kum.3	-	19	3115	c.2841C>T	c.(2839-2841)TTC>TTT	p.F947F	NPC1_uc010xaz.1_Silent_p.F680F	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	947					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TCACCCAGTCGAAATAATCGT	0.502													0	0	0	0.00632	0	21	31										A	21119389	G	A	21119389	2	1	98	1	0	0	0	0	0	0	0	1	10570	1049	37	1		1	NPC1	18	21119389	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		21119389	56957859	95	30123										
C19orf21	126353	broad.mit.edu	37	chr19	758421	758421	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	gaagccccctcggggatgccCgcaagccaacaggggtgtcg	15	14	0	0	rs112598403		TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:758421C>T	uc002lpo.2	+	2	1558	c.1475C>T	c.(1474-1476)CCG>CTG	p.P492L		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	492										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGATGCCCGCAAGCCAAC	0.632													0	0	0	0.013726	0	25	4										T	758421	C	T	758421	3	4	98	1	0	0	0	0	1	0	0	0	1913	652	23	2	1477	2	C19orf21	19	758421	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		758421	58370562	96	30124										
MUC16	94025	broad.mit.edu	37	chr19	9085867	9085867	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ctgcatgtagtggttgagtgGactgttcaattgtgcctgta	13	6	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:9085867G>A	uc002mkp.2	-	1	6152	c.5948C>T	c.(5947-5949)TCC>TTC	p.S1983F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1983	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTGAGTGGACTGTTCAAT	0.478													0	0	0	0.01441	0	58	34										A	9085867	G	A	9085867	3	1	98	1	0	0	0	0	1	0	0	0	9973	1174	41	1	37911	1	MUC16	19	9085867	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	8327446	9085867	50043116	97	30125										
ANGPTL6	83854	broad.mit.edu	37	chr19	10206748	10206748	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	acgagctgcgccagctcgcgGaacttgacgtccagctggtg	14	13	0	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:10206748G>A	uc002mmx.1	-	2	610	c.492C>T	c.(490-492)TTC>TTT	p.F164F	ANGPTL6_uc002mmy.1_Silent_p.F164F	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	164					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			CCAGCTCGCGGAACTTGACGT	0.741													0	0	0	0.008871	0	11	12										A	10206748	G	A	10206748	2	1	98	1	0	0	0	0	0	0	0	1	618	1165	41	1		1	ANGPTL6	19	10206748	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	1120881	10206748	48922235	98	30126										
RPL18A	6142	broad.mit.edu	37	chr19	17972200	17972200	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tttgcgcctaatcatgtcgtCgccaagtcccgcttctggta	9	13	2	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:17972200C>A	uc002nhp.1	+	2	152	c.117C>A	c.(115-117)GTC>GTA	p.V39V	SNORA68_uc002nhq.1_5'Flank	NM_000980	NP_000971	Q02543	RL18A_HUMAN	ribosomal protein L18a	39					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						ATCATGTCGTCGCCAAGTCCC	0.552													1	0	2.32078e-09	0.003163	2.62196e-09	11	9										A	17972200	C	A	17972200	2	1	98	1	0	0	0	0	0	0	0	1	13565	871	31	3		3	RPL18A	19	17972200	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	7765452	17972200	41156783	99	30127										
ZNF536	9745	broad.mit.edu	37	chr19	31040189	31040189	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tcccagcccgtccagggactGgtctcacctttatcccaagc	8	17	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:31040189G>T	uc002nsu.1	+	4	3801	c.3663G>T	c.(3661-3663)CTG>CTT	p.L1221L	ZNF536_uc010edd.1_Silent_p.L1221L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCCAGGGACTGGTCTCACCTT	0.647													1	0	4.62619e-21	0.019004	6.05908e-21	25	26										T	31040189	G	T	31040189	2	4	98	1	0	0	0	0	0	0	0	1	17971	1335	47	4		4	ZNF536	19	31040189	Silent	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	13067989	31040189	28088794	100	30128										
ZNF573	126231	broad.mit.edu	37	chr19	38262256	38262256	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atcacatccctgtataagtcCctctgattagggtccaggta	8	11	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:38262256C>T	uc002ohe.2	-	2	172	c.150G>A	c.(148-150)AGG>AGA	p.R50R	ZNF573_uc010efs.2_5'UTR|ZNF573_uc002ohd.2_Silent_p.R48R|ZNF573_uc002ohf.2_5'UTR|ZNF573_uc002ohg.2_5'UTR	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TGTATAAGTCCCTCTGATTAG	0.418													0	0	0	0.006122	0	16	24										T	38262256	C	T	38262256	2	4	98	1	0	0	0	0	0	0	0	1	18002	622	22	2		2	ZNF573	19	38262256	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	7222067	38262256	20866727	101	30129										
RYR1	6261	broad.mit.edu	37	chr19	38966040	38966040	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cccgactccctcacgacgtgGtgcctgcagacaaccgcgat	10	17	1	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:38966040G>A	uc002oit.2	+	29	4373	c.4243G>A	c.(4243-4245)GTG>ATG	p.V1415M	RYR1_uc002oiu.2_Missense_Mutation_p.V1415M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1415	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCACGACGTGGTGCCTGCAGA	0.607													0	0	0	0.016522	0	19	30										A	38966040	G	A	38966040	3	1	98	1	0	0	0	0	1	0	0	0	13768	1261	44	2	4357	2	RYR1	19	38966040	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	703784	38966040	20162943	102	30130										
GRIK5	2901	broad.mit.edu	37	chr19	42526200	42526200	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	aggaaggagaagtagccaggCttgcggccctgtggggagag	19	7	0	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:42526200C>A	uc002osj.1	-	13	1631	c.1596G>T	c.(1594-1596)AAG>AAT	p.K532N	GRIK5_uc002osi.1_Missense_Mutation_p.K104N|GRIK5_uc010eib.1_Missense_Mutation_p.K451N	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	532	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGTAGCCAGGCTTGCGGCCCT	0.652													1	0	6.31663e-08	0.003163	6.97657e-08	13	18										A	42526200	C	A	42526200	3	1	98	1	0	0	0	0	1	0	0	0	6777	796	28	4	1374	4	GRIK5	19	42526200	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	3560160	42526200	16602783	103	30131										
NOVA2	4858	broad.mit.edu	37	chr19	46443268	46443268	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cctggcaggaactcgcccttCttggagatctggatgcgagc	13	12	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:46443268C>T	uc002pdv.2	-	4	1380	c.1332G>A	c.(1330-1332)AAG>AAA	p.K444K		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	444	KH 3.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		ACTCGCCCTTCTTGGAGATCT	0.657													0	0	0	0.01441	0	68	118										T	46443268	C	T	46443268	2	4	98	1	0	0	0	0	0	0	0	1	10555	912	32	1		1	NOVA2	19	46443268	Silent	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	3917068	46443268	12685715	104	30132										
NLRP11	204801	broad.mit.edu	37	chr19	56297208	56297208	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	cagtcatcagcaactgctggGtttgtgtgttcaggccagtt	12	9	3	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr19:56297208G>T	uc010ygf.1	-	12	3596	c.2885C>A	c.(2884-2886)ACC>AAC	p.T962N	NLRP11_uc002qlz.2_Missense_Mutation_p.T809N|NLRP11_uc002qmb.2_Missense_Mutation_p.T863N|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	962							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CAACTGCTGGGTTTGTGTGTT	0.433													1	0	0.00074312	0.006122	0.000780013	18	28										T	56297208	G	T	56297208	3	4	98	1	0	0	0	0	1	0	0	0	10473	1261	44	4	220	4	NLRP11	19	56297208	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	9853940	56297208	2831775	105	30133										
PCNT	5116	broad.mit.edu	37	chr21	47769714	47769714	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	agttcaagttcaaagagagcGagaaagaaaaacagctggag	12	5	2	3			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr21:47769714G>A	uc002zji.3	+	8	1431	c.1324G>A	c.(1324-1326)GAG>AAG	p.E442K	PCNT_uc002zjj.2_Missense_Mutation_p.E324K|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	442	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					CAAAGAGAGCGAGAAAGAAAA	0.433													0	0	0	0.007291	0	21	35										A	47769714	G	A	47769714	3	1	98	1	0	0	0	0	1	0	0	0	11590	1059	37	1	1354	1	PCNT	21	47769714	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08		47769714	360181	106	30134										
HIRA	7290	broad.mit.edu	37	chr22	19393309	19393309	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	caacaggcagtcccactcacCgcctgaatgattccggagga	10	14	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:19393309C>T	uc002zpf.1	-	5	617	c.397G>A	c.(397-399)GAT>AAT	p.D133N	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.D133N|HIRA_uc010gro.1_Missense_Mutation_p.D89N|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	133	WD 3.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TCCCACTCACCGCCTGAATGA	0.607													0	0	0	0.01892	0	22	37										T	19393309	C	T	19393309	3	4	98	1	0	0	0	0	1	0	0	0	7120	666	23	2	2740	2	HIRA	22	19393309	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		19393309	31911257	107	30135										
PIWIL3	440822	broad.mit.edu	37	chr22	25131817	25131817	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgcattaagtaagggtaattCtcttatttctcttgaccagt	7	7	2	1			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:25131817C>T	uc003abd.1	-	13	1909	c.1492G>A	c.(1492-1494)GAA>AAA	p.E498K	PIWIL3_uc011ajx.1_Missense_Mutation_p.E389K|PIWIL3_uc011ajy.1_Missense_Mutation_p.E389K|PIWIL3_uc010gut.1_Missense_Mutation_p.E498K	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	498					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						AAGGGTAATTCTCTTATTTCT	0.373													0	0	0	0.01441	0	37	87										T	25131817	C	T	25131817	3	4	98	1	0	0	0	0	1	0	0	0	11959	922	32	1	1192	1	PIWIL3	22	25131817	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08	5738508	25131817	26172749	108	30136										
CCDC157	550631	broad.mit.edu	37	chr22	30772567	30772567	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	ggcagccctgcacatccccaTctcggcagccctgcagccag	10	19	1	0			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:30772567T>C	uc011aku.1	+	12	2752	c.2092T>C	c.(2092-2094)TCT>CCT	p.S698P	CCDC157_uc011akv.1_Missense_Mutation_p.S698P|uc003aho.1_5'Flank	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	698										central_nervous_system(1)	1						CACATCCCCATCTCGGCAGCC	0.667													0	0	0	0.010729	0	7	281										C	30772567	T	C	30772567	3	2	98	1	0	0	0	0	1	0	0	0	2789	1435	50	5	2130	5	CCDC157	22	30772567	Missense_Mutation	SNP	T	TCGA-G2-A3IB-01A-11D-A20D-08	5640750	30772567	20531999	109	30137										
ISX	91464	broad.mit.edu	37	chr22	35463109	35463109	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgaggtgggccctgctctctGcaggggtatggagagaaata	16	7	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:35463109G>A	uc003anj.2	+	1	980	c.29G>A	c.(28-30)TGC>TAC	p.C10Y	ISX_uc011amg.1_5'UTR	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	10						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						CCTGCTCTCTGCAGGGGTATG	0.602													0	0	0	0.00632	0	22	24										A	35463109	G	A	35463109	3	1	98	1	0	0	0	0	1	0	0	0	7865	1319	46	2	31	2	ISX	22	35463109	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	4690542	35463109	15841457	110	30138										
SH3BP1	23616	broad.mit.edu	37	chr22	38061710	38061710	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	atggtgggtgaccgcctggaGaccgacatcctctttggcca	13	12	1	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chr22:38061710G>T	uc003atj.1	+	17	2537	c.1650G>T	c.(1648-1650)GAG>GAT	p.E550D	PDXP_uc003atm.1_Missense_Mutation_p.E241D			Q9Y3L3	3BP1_HUMAN	SubName: Full=cDNA FLJ44925 fis, clone BRAMY3014613, highly similar to Homo sapiens SH3-domain binding protein 1 (SH3BP1);	Error:Variant_position_missing_in_Q9Y3L3_after_alignment					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					ACCGCCTGGAGACCGACATCC	0.647													1	0	2.16659e-41	0.01441	3.34016e-41	68	150										T	38061710	G	T	38061710	3	4	98	1	0	0	0	0	1	0	0	0	14244	933	33	3		3	SH3BP1	22	38061710	Missense_Mutation	SNP	G	TCGA-G2-A3IB-01A-11D-A20D-08	2598601	38061710	13242856	111	30139										
GUCY2F	2986	broad.mit.edu	37	chrX	108708376	108708376	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tgaatgtgtacttacttgatCgaactccagcttctcaggaa	8	9	1	2	rs149453194	byFrequency	TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chrX:108708376C>A	uc004eod.3	-	3	1303	c.1027G>T	c.(1027-1029)GAT>TAT	p.D343Y	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	343	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CTTACTTGATCGAACTCCAGC	0.433													1	0	8.40228e-50	0.01441	1.33714e-49	61	7										A	108708376	C	A	108708376	3	1	98	1	0	0	0	0	1	0	0	0	6898	884	31	3	2367	3	GUCY2F	23	108708376	Missense_Mutation	SNP	C	TCGA-G2-A3IB-01A-11D-A20D-08		108708376	46562184	112	30140										
AFF2	2334	broad.mit.edu	37	chrX	148055007	148055007	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.20353982300885	23	1.05107979510806e-06	2.95954399298451	3.53858520900322	2.79795109549091	0.00665384014060916	0.0227631373231366	15	tcttcctgtttcagttcgagAaatttggcaaagctgtgaat	9	7	2	2			TCGA-G2-A3IB-01A-11D-A20D-08	TCGA-G2-A3IB-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1325348c-64b8-4be6-a078-8fac1b3bb44f	bbfeacc2-2b94-4c15-aa40-aa9c17508834	g.chrX:148055007A>C	uc004fcp.2	+	16	3753	c.3274A>C	c.(3274-3276)AAA>CAA	p.K1092Q	AFF2_uc004fcq.2_Missense_Mutation_p.K1082Q|AFF2_uc004fcr.2_Missense_Mutation_p.K1053Q|AFF2_uc011mxb.1_Missense_Mutation_p.K1057Q|AFF2_uc004fcs.2_Missense_Mutation_p.K1057Q|AFF2_uc011mxc.1_Missense_Mutation_p.K733Q	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1092					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGTTCGAGAAATTTGGCAA	0.373													0	0	0	0.01441	0	76	6										C	148055007	A	C	148055007	3	2	98	1	0	0	0	0	1	0	0	0	357	247	9	5	3391	5	AFF2	23	148055007	Missense_Mutation	SNP	A	TCGA-G2-A3IB-01A-11D-A20D-08	39346631	148055007	7215553	113	30141										
PRKCZ	5590	broad.mit.edu	37	chr1	2105377	2105377	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgctgggagtcctcatgtttGagatgatggccgggcgctcc	15	11	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:2105377G>C	uc001aiq.2	+	14	1488	c.1327G>C	c.(1327-1329)GAG>CAG	p.E443Q	PRKCZ_uc001air.2_Missense_Mutation_p.E260Q|PRKCZ_uc010nyw.1_Missense_Mutation_p.E339Q|PRKCZ_uc001ais.2_Missense_Mutation_p.E260Q|PRKCZ_uc009vla.2_Missense_Mutation_p.E267Q|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc001ait.2_Missense_Mutation_p.E291Q	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	443	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CCTCATGTTTGAGATGATGGC	0.627											OREG0013007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	51	84										C	2105377	G	C	2105377	3	2	99	1	0	0	0	0	1	0	0	0	12517	1291	45	1	1381	1	PRKCZ	1	2105377	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		2105377	247145244	1	30142										
ACTRT2	140625	broad.mit.edu	37	chr1	2938571	2938571	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaacccagcgaccagcccctGcttgcaacggagccctccct	8	19	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:2938571G>A	uc001ajz.2	+	1	526	c.321G>A	c.(319-321)CTG>CTA	p.L107L		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	107						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACCAGCCCCTGCTTGCAACGG	0.597													0	0	0	0.010818	0	31	49										A	2938571	G	A	2938571	2	1	99	1	0	0	0	0	0	0	0	1	219	1306	46	2		2	ACTRT2	1	2938571	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	833194	2938571	246312050	2	30143										
THAP3	90326	broad.mit.edu	37	chr1	6688662	6688662	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcatctgctccgagcacttcCggccagagtgcttcagcgcc	10	16	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:6688662C>T	uc001aoc.2	+	3	337	c.178C>T	c.(178-180)CGG>TGG	p.R60W	THAP3_uc001aod.2_Missense_Mutation_p.R60W|THAP3_uc001aoe.1_Missense_Mutation_p.R60W			Q8WTV1	THAP3_HUMAN	RecName: Full=THAP domain-containing protein 3;	60	THAP-type.						DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CGAGCACTTCCGGCCAGAGTG	0.607													0	0	0	0.00333	0	19	24										T	6688662	C	T	6688662	3	4	99	1	0	0	0	0	1	0	0	0	15842	643	23	2	184	2	THAP3	1	6688662	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3750091	6688662	242561959	3	30144										
CAMTA1	23261	broad.mit.edu	37	chr1	7724825	7724825	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tccccatcctcccgggcaacGtggtgcagggactctacccc	10	18	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:7724825G>A	uc001aoi.2	+	9	2425	c.2218G>A	c.(2218-2220)GTG>ATG	p.V740M		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	740					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCCGGGCAACGTGGTGCAGGG	0.647													0	0	0	0.013114	0	36	56										A	7724825	G	A	7724825	3	1	99	1	0	0	0	0	1	0	0	0	2613	1145	40	2	2252	2	CAMTA1	1	7724825	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1036163	7724825	241525796	4	30145										
TARDBP	23435	broad.mit.edu	37	chr1	11078800	11078800	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcctttctaggtcaagaaagAtcttaagactggtcattcaa	7	8	5	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:11078800A>C	uc001art.2	+	4	547	c.413A>C	c.(412-414)GAT>GCT	p.D138A	TARDBP_uc010oap.1_Missense_Mutation_p.D22A	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	138	RRM 1.			Missing: Completely abolishes RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GTCAAGAAAGATCTTAAGACT	0.368													0	0	0	0.00308	0	6	137										C	11078800	A	C	11078800	3	2	99	1	0	0	0	0	1	0	0	0	15554	333	12	5	423	5	TARDBP	1	11078800	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	3353975	11078800	238171821	5	30146										
TNFRSF8	943	broad.mit.edu	37	chr1	12183421	12183421	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accccaccccagagaatggcGaggcgcctgccaggtgactc	12	16	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:12183421G>C	uc001atq.2	+	9	1249	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q	TNFRSF8_uc010obc.1_Missense_Mutation_p.E232Q|TNFRSF8_uc001atr.2_5'Flank|TNFRSF8_uc001ats.2_5'Flank	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	343	Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGAATGGCGAGGCGCCTGC	0.652													0	0	0	0.004482	0	7	14										C	12183421	G	C	12183421	3	2	99	1	0	0	0	0	1	0	0	0	16296	1059	37	1	1061	1	TNFRSF8	1	12183421	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1104621	12183421	237067200	6	30147										
KDM1A	23028	broad.mit.edu	37	chr1	23376901	23376901	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtggagggcgcagctttccAgagccgacttcctcatgacc	12	13	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:23376901A>G	uc001bgi.2	+	3	688	c.539A>G	c.(538-540)CAG>CGG	p.Q180R	KDM1A_uc001bgj.2_Missense_Mutation_p.Q200R	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	180	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						GCAGCTTTCCAGAGCCGACTT	0.448													0	0	0	0.010504	0	19	59										G	23376901	A	G	23376901	3	3	99	1	0	0	0	0	1	0	0	0	8122	188	7	5	613	5	KDM1A	1	23376901	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	11193480	23376901	225873720	7	30148										
NIPAL3	57185	broad.mit.edu	37	chr1	24768670	24768670	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtgttcgcctcctacgccttCgcgccgctgtcactcatcgt	9	17	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:24768670C>T	uc001bjh.2	+	4	695	c.288C>T	c.(286-288)TTC>TTT	p.F96F	NIPAL3_uc010oek.1_Silent_p.F96F|NIPAL3_uc001bjg.2_Silent_p.F96F|NIPAL3_uc009vrc.2_Silent_p.F14F	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	96	Helical; (Potential).					integral to membrane					0						CCTACGCCTTCGCGCCGCTGT	0.632													0	0	0	0.01441	0	50	93										T	24768670	C	T	24768670	2	4	99	1	0	0	0	0	0	0	0	1	10426	883	31	1		1	NIPAL3	1	24768670	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1391769	24768670	224481951	8	30149										
ADC	113451	broad.mit.edu	37	chr1	33562402	33562402	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggggcgctactacgtgacctCggccttcactgtggcagtca	13	13	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:33562402C>T	uc001bwr.2	+	9	1435	c.848C>T	c.(847-849)TCG>TTG	p.S283L	ADC_uc001bws.2_Missense_Mutation_p.S283L|ADC_uc009vue.2_Missense_Mutation_p.S283L|ADC_uc001bwt.1_Missense_Mutation_p.S188L|ADC_uc001bwu.2_Missense_Mutation_p.S188L|ADC_uc001bwv.2_Missense_Mutation_p.S188L|ADC_uc001bww.2_Missense_Mutation_p.S188L|ADC_uc001bwx.1_Missense_Mutation_p.S260L|ADC_uc001bwz.1_Missense_Mutation_p.S283L|ADC_uc009vuf.1_Missense_Mutation_p.S125L|ADC_uc001bwy.1_Missense_Mutation_p.S132L|ADC_uc009vug.2_Missense_Mutation_p.S283L	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	283					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	TACGTGACCTCGGCCTTCACT	0.587													0	0	0	0.001984	0	6	143										T	33562402	C	T	33562402	3	4	99	1	0	0	0	0	1	0	0	0	287	893	31	1	870	1	ADC	1	33562402	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	8793732	33562402	215688219	9	30150										
CSMD2	114784	broad.mit.edu	37	chr1	33987121	33987121	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgacagagccttggtagatGaaggtggctccggaggactc	15	8	0	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:33987121G>A	uc001bxn.1	-	67	10136	c.10107C>T	c.(10105-10107)TTC>TTT	p.F3369F	CSMD2_uc001bxm.1_Silent_p.F3513F	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3369	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTTGGTAGATGAAGGTGGCTC	0.577													0	0	0	0.005524	0	27	48										A	33987121	G	A	33987121	2	1	99	1	0	0	0	0	0	0	0	1	3945	1281	45	1		1	CSMD2	1	33987121	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	424719	33987121	215263500	10	30151										
ZMYM6	9204	broad.mit.edu	37	chr1	35452810	35452810	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttttttgttttgactcagtCaaagctgaaaaggcagcatc	8	7	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:35452810C>G	uc001byh.2	-	16	4101	c.3873G>C	c.(3871-3873)TTG>TTC	p.L1291F	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Missense_Mutation_p.L1194F	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1291					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TTGACTCAGTCAAAGCTGAAA	0.368													0	0	0	0.006122	0	14	32										G	35452810	C	G	35452810	3	3	99	1	0	0	0	0	1	0	0	0	17701	825	29	1	108	1	ZMYM6	1	35452810	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1465689	35452810	213797811	11	30152										
SNIP1	79753	broad.mit.edu	37	chr1	38003556	38003556	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgcctgagccaaggtcaatGatgtagggcttcactcttcg	11	10	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:38003556G>A	uc001cbi.2	-	4	1057	c.984C>T	c.(982-984)ATC>ATT	p.I328I	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	328	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				CAAGGTCAATGATGTAGGGCT	0.433													0	0	0	0.013726	0	30	52										A	38003556	G	A	38003556	2	1	99	1	0	0	0	0	0	0	0	1	14848	1280	45	1		1	SNIP1	1	38003556	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2550746	38003556	211247065	12	30153										
CCDC18	343099	broad.mit.edu	37	chr1	93692001	93692001	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aacagttaaagaagaaatctGaagaggtaaattaacattta	7	3	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:93692001G>A	uc001dpq.2	+	17	2809	c.2641G>A	c.(2641-2643)GAA>AAA	p.E881K	CCDC18_uc009wdl.1_Missense_Mutation_p.E398K	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	762	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GAAGAAATCTGAAGAGGTAAA	0.249													0	0	0	0.004007	0	12	26										A	93692001	G	A	93692001	3	1	99	1	0	0	0	0	1	0	0	0	2794	1291	45	1	2707	1	CCDC18	1	93692001	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	55688445	93692001	155558620	13	30154										
DPYD	1806	broad.mit.edu	37	chr1	97981460	97981460	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	taggagtgtaaaagaggggtAgttcaggcttggcagaaacg	16	4	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:97981460A>T	uc001drv.2	-	13	1699	c.1562T>A	c.(1561-1563)CTA>CAA	p.L521Q		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	521					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAAGAGGGGTAGTTCAGGCTT	0.388													0	0	0	0.010729	0	7	51										T	97981460	A	T	97981460	3	4	99	1	0	0	0	0	1	0	0	0	4745	420	15	5	1559	5	DPYD	1	97981460	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	4289459	97981460	151269161	14	30155										
DPYD	1806	broad.mit.edu	37	chr1	98039506	98039506	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aatggcagaaattcacacttTtcttccttagcaagttccat	5	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:98039506T>C	uc001drv.2	-	11	1286	c.1149A>G	c.(1147-1149)GAA>GAG	p.E383E		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	383					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ATTCACACTTTTCTTCCTTAG	0.368													0	0	0	0.007413	0	16	29										C	98039506	T	C	98039506	2	2	99	1	0	0	0	0	0	0	0	1	4745	1838	64	5		5	DPYD	1	98039506	Silent	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	58046	98039506	151211115	15	30156										
PALMD	54873	broad.mit.edu	37	chr1	100154591	100154591	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aatccccaacagagtatcatGagcctgtatatgccaatccc	6	13	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:100154591G>C	uc001dsg.2	+	7	1218	c.775G>C	c.(775-777)GAG>CAG	p.E259Q	PALMD_uc001dsf.2_Missense_Mutation_p.E259Q	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	259					regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		AGAGTATCATGAGCCTGTATA	0.453													0	0	0	0.013114	0	37	78										C	100154591	G	C	100154591	3	2	99	1	0	0	0	0	1	0	0	0	11411	1291	45	1	801	1	PALMD	1	100154591	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2115085	100154591	149096030	16	30157										
COL11A1	1301	broad.mit.edu	37	chr1	103487275	103487275	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctacttacaggctcaaccacTgctggttctcctttctgtcc	6	15	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:103487275T>C	uc001dul.2	-	9	1614	c.1296A>G	c.(1294-1296)GCA>GCG	p.A432A	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Silent_p.A444A|COL11A1_uc001dun.2_Silent_p.A393A|COL11A1_uc009weh.2_Silent_p.A316A	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	432	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTCAACCACTGCTGGTTCTC	0.353													0	0	0	0.004878	0	26	35										C	103487275	T	C	103487275	2	2	99	1	0	0	0	0	0	0	0	1	3667	1567	55	5		5	COL11A1	1	103487275	Silent	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	3332684	103487275	145763346	17	30158										
POLR3C	10623	broad.mit.edu	37	chr1	145609263	145609263	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggttcttatcagatggactCcaattttttctacaatctct	5	10	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:145609263C>G	uc001eoh.2	-	2	235	c.74G>C	c.(73-75)GGA>GCA	p.G25A	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Missense_Mutation_p.G38A|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Missense_Mutation_p.G25A	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	25					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CAGATGGACTCCAATTTTTTC	0.428													0	0	0	0.008871	0	16	72										G	145609263	C	G	145609263	3	3	99	1	0	0	0	0	1	0	0	0	12230	855	30	1	1586	1	POLR3C	1	145609263	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	42121988	145609263	103641358	18	30159										
SV2A	9900	broad.mit.edu	37	chr1	149884828	149884828	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttctcagcgctgggcagcaCgaagcccaccacaaagacct	9	15	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:149884828C>T	uc001etg.2	-	2	1056	c.565G>A	c.(565-567)GTG>ATG	p.V189M	SV2A_uc001eth.2_Missense_Mutation_p.V189M	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	189	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTGGGCAGCACGAAGCCCACC	0.582													0	0	0	0.01441	0	105	87										T	149884828	C	T	149884828	3	4	99	1	0	0	0	0	1	0	0	0	15414	536	19	2	1711	2	SV2A	1	149884828	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4275565	149884828	99365793	19	30160										
RPTN	126638	broad.mit.edu	37	chr1	152129435	152129435	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagtctctgggtcatttggtCtctgttaggagataaaacaa	10	7	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:152129435C>T	uc001ezs.1	-	3	205	c.140G>A	c.(139-141)AGA>AAA	p.R47K		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	47	S-100-like (By similarity).|EF-hand 1.					proteinaceous extracellular matrix	calcium ion binding				0						GTCATTTGGTCTCTGTTAGGA	0.433													0	0	0	0.010729	0	9	156										T	152129435	C	T	152129435	3	4	99	1	0	0	0	0	1	0	0	0	13664	927	32	1	2218	1	RPTN	1	152129435	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2244607	152129435	97121186	20	30161										
S100A9	6280	broad.mit.edu	37	chr1	153330787	153330787	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcaaaatgtcgcagctggaaCgcaacatagagaccatcatc	9	11	1	1	rs140601192	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:153330787C>T	uc001fbq.2	+	2	71	c.28C>T	c.(28-30)CGC>TGC	p.R10C		NM_002965	NP_002956	P06702	S10A9_HUMAN	S100 calcium-binding protein A9	10					cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGCTGGAACGCAACATAGA	0.478													0	0	0	0.01441	0	39	105										T	153330787	C	T	153330787	3	4	99	1	0	0	0	0	1	0	0	0	13787	536	19	2	30	2	S100A9	1	153330787	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1201352	153330787	95919834	21	30162										
DAP3	7818	broad.mit.edu	37	chr1	155698864	155698867	+	Frame_Shift_Del	DEL	AGAG	AGAG	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agagaagtatgtctggaataAgagagaaagcactgagaaag							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:155698864_155698867delAGAG	uc001flq.2	+	8	804_807	c.635_638delAGAG	c.(634-639)AAGAGAfs	p.K212fs	DAP3_uc001flr.2_Frame_Shift_Del_p.K212fs|DAP3_uc001fls.2_Frame_Shift_Del_p.K212fs|DAP3_uc010pgl.1_Frame_Shift_Del_p.K171fs|DAP3_uc001flt.2_Frame_Shift_Del_p.K178fs|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Frame_Shift_Del_p.K178fs	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	212_213					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GTCTGGAATAAGAGAGAAAGCACT	0.397																		9	61	---	---								-	155698867	AGAG	-	155698864	7	5	99	1	0	1	0	1	0	0	0	0	4234	72	3	0	661	0	DAP3	1	155698864	Frame_Shift_Del	DEL	AGAG	TCGA-G2-A3IE-01A-11D-A20D-08	2368077	155698864	93551757	22	30163										
MEX3A	92312	broad.mit.edu	37	chr1	156046708	156046708	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggaggaggaggaggaggcaGaggagaagagcacggaggtg	23	3	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:156046708G>C	uc001fnd.3	-	2	1220	c.1220C>G	c.(1219-1221)TCT>TGT	p.S407C		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	407	Poly-Ser.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					ggaggaggcagaggagaagAG	0.622													0	0	0	0.000602	0	4	5										C	156046708	G	C	156046708	3	2	99	1	0	0	0	0	1	0	0	0	9509	942	33	1	346	1	MEX3A	1	156046708	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	347844	156046708	93203913	23	30164										
OR10K1	391109	broad.mit.edu	37	chr1	158435644	158435644	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catttctttcctgggctgtgCcatccaaatgttttccttcc	6	13	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:158435644C>G	uc010pij.1	+	1	293	c.293C>G	c.(292-294)GCC>GGC	p.A98G		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTGGGCTGTGCCATCCAAATG	0.493													0	0	0	0.001168	0	4	123										G	158435644	C	G	158435644	3	3	99	1	0	0	0	0	1	0	0	0	10913	739	26	4	295	4	OR10K1	1	158435644	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2388936	158435644	90814977	24	30165										
OR10X1	128367	broad.mit.edu	37	chr1	158549434	158549434	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtcagcgtatagcaggtctCagagaaggagagtgcactaa	14	7	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:158549434C>T	uc010pin.1	-	1	256	c.256G>A	c.(256-258)GAG>AAG	p.E86K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	86	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TAGCAGGTCTCAGAGAAGGAG	0.498													0	0	0	0.008871	0	18	42										T	158549434	C	T	158549434	3	4	99	1	0	0	0	0	1	0	0	0	10922	835	29	1	719	1	OR10X1	1	158549434	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	113790	158549434	90701187	25	30166										
ASPM	259266	broad.mit.edu	37	chr1	197072567	197072567	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atatactccatacattgcttCcttcctgcagtccatgctct	4	14	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:197072567C>T	uc001gtu.2	-	18	6071	c.5814G>A	c.(5812-5814)AGG>AGA	p.R1938R	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1938					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TACATTGCTTCCTTCCTGCAG	0.423													0	0	0	0.01441	0	59	158										T	197072567	C	T	197072567	2	4	99	1	0	0	0	0	0	0	0	1	1056	854	30	1		1	ASPM	1	197072567	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	38523133	197072567	52178054	26	30167										
MDM4	4194	broad.mit.edu	37	chr1	204501325	204501325	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctctctttaacagccctctCtatgatatgctaagaaagaa	5	10	3	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:204501325C>G	uc001hba.2	+	5	456	c.294C>G	c.(292-294)CTC>CTG	p.L98L	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_5'UTR|MDM4_uc001hay.1_Silent_p.L98L|MDM4_uc001hbb.2_5'UTR|MDM4_uc010pqy.1_RNA|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	98	SWIB.				apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			ACAGCCCTCTCTATGATATGC	0.358			A		GBM|bladder|retinoblastoma								0	0	0	0.012319	0	16	38										G	204501325	C	G	204501325	2	3	99	1	0	0	0	0	0	0	0	1	9414	900	32	1		1	MDM4	1	204501325	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	7428758	204501325	44749296	27	30168										
SYT14	255928	broad.mit.edu	37	chr1	210187104	210187104	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgggtttccagatcttggttCagaatacagtacaaggaaga	11	7	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:210187104C>G	uc009xcv.2	+	3	260	c.188C>G	c.(187-189)TCA>TGA	p.S63*	SYT14_uc001hhs.3_Nonsense_Mutation_p.S108*|SYT14_uc001hht.3_Nonsense_Mutation_p.S63*|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Nonsense_Mutation_p.S108*|SYT14_uc010pso.1_Nonsense_Mutation_p.S25*	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	63	Cytoplasmic (Potential).					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		GATCTTGGTTCAGAATACAGT	0.328													0	0	0	0.004007	0	14	68										G	210187104	C	G	210187104	4	3	99	1	0	0	0	0	0	1	0	0	15467	838	29	1	337	1	SYT14	1	210187104	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5685779	210187104	39063517	28	30169										
MIA3	375056	broad.mit.edu	37	chr1	222833629	222833629	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctctctctgctactctcaatCgaagagatatgcctagaagt	7	11	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:222833629C>T	uc001hnl.2	+	24	5095	c.5086C>T	c.(5086-5088)CGA>TGA	p.R1696*	MIA3_uc001hnm.2_Nonsense_Mutation_p.R574*	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1696	Pro-rich.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TACTCTCAATCGAAGAGATAT	0.463													0	0	0	0.004656	0	19	54										T	222833629	C	T	222833629	4	4	99	1	0	0	0	0	0	1	0	0	9565	876	31	1	5180	1	MIA3	1	222833629	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	12646525	222833629	26416992	29	30170										
ITPKB	3707	broad.mit.edu	37	chr1	226827299	226827299	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agtgaactctctgaaggcctCggtgacctgctccctcgttt	10	13	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:226827299C>T	uc010pvo.1	-	6	2852	c.2512G>A	c.(2512-2514)GAG>AAG	p.E838K		NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	838							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				CTGAAGGCCTCGGTGACCTGC	0.567													0	0	0	0.003954	0	16	35										T	226827299	C	T	226827299	3	4	99	1	0	0	0	0	1	0	0	0	7918	893	31	1	340	1	ITPKB	1	226827299	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3993670	226827299	22423322	30	30171										
NID1	4811	broad.mit.edu	37	chr1	236205225	236205225	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cttaccaactcctgtttcctCaacttcatccacatctatga	2	15	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:236205225C>A	uc001hxo.2	-	4	1222	c.1120G>T	c.(1120-1122)GAG>TAG	p.E374*	NID1_uc009xgd.2_Nonsense_Mutation_p.E374*	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	374					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCTGTTTCCTCAACTTCATCC	0.512													1	0	4.39465e-27	0.013726	4.8072e-27	27	42										A	236205225	C	A	236205225	4	1	99	1	0	0	0	0	0	1	0	0	10414	835	29	3	2691	3	NID1	1	236205225	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9377926	236205225	13045396	31	30172										
OR2T6	254879	broad.mit.edu	37	chr1	248550938	248550938	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaacaatgaaaccttgaccaGaggctttaccctcatggggc	9	11	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:248550938G>C	uc001iei.1	+	1	29	c.29G>C	c.(28-30)AGA>ACA	p.R10T		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTTGACCAGAGGCTTTACC	0.408													0	0	0	0.010504	0	14	62										C	248550938	G	C	248550938	3	2	99	1	0	0	0	0	1	0	0	0	11029	942	33	1	31	1	OR2T6	1	248550938	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	12345713	248550938	699683	32	30173										
RRM2	6241	broad.mit.edu	37	chr2	10263127	10263127	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagccgccggccctgagcggGacccgcgtcctggccagcaa	14	18	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:10263127G>A	uc002rah.2	+	2	308	c.117G>A	c.(115-117)GGG>GGA	p.G39G		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	39					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCCTGAGCGGGACCCGCGTCC	0.751													0	0	0	0.009096	0	3	5										A	10263127	G	A	10263127	2	1	99	1	0	0	0	0	0	0	0	1	13682	1161	41	1		1	RRM2	2	10263127	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		10263127	232936246	33	30174										
KCNF1	3754	broad.mit.edu	37	chr2	11053189	11053189	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agctgcaggtgctggacgccGagggcaaccgcgtggagcac	17	12	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:11053189G>A	uc002rax.2	+	1	1127	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	213						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GCTGGACGCCGAGGGCAACCG	0.667													0	0	0	0.00278	0	18	22										A	11053189	G	A	11053189	3	1	99	1	0	0	0	0	1	0	0	0	8026	1059	37	1	639	1	KCNF1	2	11053189	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	790062	11053189	232146184	34	30175										
SMC6	79677	broad.mit.edu	37	chr2	17877556	17877556	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgaaaaaaatggtgaaaaacCtctagttctttctctttcat	5	7	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:17877556C>G	uc002rco.2	-	22	2828	c.2532G>C	c.(2530-2532)GAG>GAC	p.E844D	SMC6_uc010exo.2_Missense_Mutation_p.E844D|SMC6_uc002rcn.2_Missense_Mutation_p.E844D|SMC6_uc002rcp.1_Missense_Mutation_p.E870D	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	844	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGAAAAACCTCTAGTTCTT	0.303													0	0	0	0.006214	0	9	19										G	17877556	C	G	17877556	3	3	99	1	0	0	0	0	1	0	0	0	14787	695	24	4	771	4	SMC6	2	17877556	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	6824367	17877556	225321817	35	30176										
OTOF	9381	broad.mit.edu	37	chr2	26706333	26706333	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acctcataccccagtaccttCtggccagcaaagaagacttg	7	14	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:26706333C>T	uc002rhk.2	-	13	1516	c.1389G>A	c.(1387-1389)CAG>CAA	p.Q463Q		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	463	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGTACCTTCTGGCCAGCAA	0.567													0	0	0	0.00632	0	20	44										T	26706333	C	T	26706333	2	4	99	1	0	0	0	0	0	0	0	1	11303	912	32	1		1	OTOF	2	26706333	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	8828777	26706333	216493040	36	30177										
GCKR	2646	broad.mit.edu	37	chr2	27726416	27726416	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agactggagttcaacattccGacaagtagcagagcggatgc	12	9	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27726416G>A	uc002rky.2	+	9	746	c.680G>A	c.(679-681)CGA>CAA	p.R227Q	GCKR_uc010ezd.2_Missense_Mutation_p.R227Q|GCKR_uc010ylu.1_Missense_Mutation_p.R37Q	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	227	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					TCAACATTCCGACAAGTAGCA	0.488													0	0	0	0.000602	0	3	63										A	27726416	G	A	27726416	3	1	99	1	0	0	0	0	1	0	0	0	6294	1058	37	1	714	1	GCKR	2	27726416	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1020083	27726416	215472957	37	30178										
MRPL33	9553	broad.mit.edu	37	chr2	27997305	27997305	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcttagaaacattctggtgaGaatggtgagcgaagctggga	14	5	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27997305G>C	uc002rlm.1	+	3	117	c.56G>C	c.(55-57)AGA>ACA	p.R19T	MRPL33_uc002rln.1_Intron	NM_004891	NP_004882	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33 isoform a	19					translation	mitochondrion|ribosome	structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.155)					ATTCTGGTGAGAATGGTGAGC	0.423													0	0	0	0.01441	0	51	99										C	27997305	G	C	27997305	3	2	99	1	0	0	0	0	1	0	0	0	9796	942	33	1	66	1	MRPL33	2	27997305	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	270889	27997305	215202068	38	30179										
MRPL33	9553	broad.mit.edu	37	chr2	27997348	27997348	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtttctgcttcaacaccaaGagaaaccgactgcgggaaaa	10	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27997348G>A	uc002rlm.1	+	3	160	c.99G>A	c.(97-99)AAG>AAA	p.K33K	MRPL33_uc002rln.1_Intron	NM_004891	NP_004882	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33 isoform a	33					translation	mitochondrion|ribosome	structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.155)					TCAACACCAAGAGAAACCGAC	0.453													0	0	0	0.01441	0	51	88										A	27997348	G	A	27997348	2	1	99	1	0	0	0	0	0	0	0	1	9796	933	33	1		1	MRPL33	2	27997348	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	43	27997348	215202025	39	30180										
CLIP4	79745	broad.mit.edu	37	chr2	29386751	29386751	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggcaagaatgatggttcagTtggaggtgtgcagtatttta	14	3	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:29386751T>G	uc002rmv.2	+	13	1828	c.1589T>G	c.(1588-1590)GTT>GGT	p.V530G	CLIP4_uc002rmu.2_Missense_Mutation_p.V530G|CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	530	CAP-Gly 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GATGGTTCAGTTGGAGGTGTG	0.378													0	0	0	0.014323	0	19	109										G	29386751	T	G	29386751	3	3	99	1	0	0	0	0	1	0	0	0	3535	1725	60	5	1635	5	CLIP4	2	29386751	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	1389403	29386751	213812622	40	30181										
SRBD1	55133	broad.mit.edu	37	chr2	45616464	45616464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatactcataacacccgaatGaggtccagagtaatcctaga	8	10	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:45616464G>A	uc002rus.2	-	21	3049	c.2973C>T	c.(2971-2973)CTC>CTT	p.L991L	SRBD1_uc010yoc.1_Silent_p.L510L	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	991	S1 motif.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ACACCCGAATGAGGTCCAGAG	0.448													0	0	0	0.01441	0	37	69										A	45616464	G	A	45616464	2	1	99	1	0	0	0	0	0	0	0	1	15132	1277	45	1		1	SRBD1	2	45616464	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	16229713	45616464	197582909	41	30182										
TTC7A	57217	broad.mit.edu	37	chr2	47277133	47277133	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtgagggcctcaccatgaaGaagcagagtggcatgcacct	14	10	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:47277133G>T	uc002rvo.2	+	17	2333	c.1965G>T	c.(1963-1965)AAG>AAT	p.K655N	TTC7A_uc002rvm.2_Missense_Mutation_p.K621N|TTC7A_uc002rvn.1_Missense_Mutation_p.K497N|TTC7A_uc010fbb.2_Missense_Mutation_p.K679N|TTC7A_uc010fbc.2_Missense_Mutation_p.K301N|TTC7A_uc002rvp.2_Missense_Mutation_p.K536N|TTC7A_uc002rvq.2_Missense_Mutation_p.K395N|TTC7A_uc002rvr.2_Missense_Mutation_p.K104N	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	655							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TCACCATGAAGAAGCAGAGTG	0.572													1	0	3.41278e-10	0.00499	3.63668e-10	12	34										T	47277133	G	T	47277133	3	4	99	1	0	0	0	0	1	0	0	0	16709	933	33	3	2031	3	TTC7A	2	47277133	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1660669	47277133	195922240	42	30183										
FAM161A	84140	broad.mit.edu	37	chr2	62066591	62066591	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgtcctctggaagataccgtGggcacgggagggttgcagtt	16	9	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:62066591G>T	uc010ypo.1	-	3	1650	c.1548C>A	c.(1546-1548)CCC>CCA	p.P516P	FAM161A_uc002sbm.3_Silent_p.P516P|FAM161A_uc002sbn.3_Silent_p.P326P|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Silent_p.P407P	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	516					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						AAGATACCGTGGGCACGGGAG	0.498													1	0	1.57019e-19	0.007835	1.70715e-19	30	82										T	62066591	G	T	62066591	2	4	99	1	0	0	0	0	0	0	0	1	5472	1335	47	4		4	FAM161A	2	62066591	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	14789458	62066591	181132782	43	30184										
ARHGAP25	9938	broad.mit.edu	37	chr2	69002384	69002384	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agtgtgatgactggcgagcaGatggctgccttccatccatc	12	11	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:69002384G>A	uc002seu.2	+	2	457	c.93G>A	c.(91-93)CAG>CAA	p.Q31Q	ARHGAP25_uc010yqk.1_Silent_p.Q5Q|ARHGAP25_uc010fdg.2_Silent_p.Q31Q|ARHGAP25_uc010yql.1_Silent_p.Q31Q|ARHGAP25_uc002sev.2_Silent_p.Q24Q|ARHGAP25_uc002sew.2_Silent_p.Q24Q|ARHGAP25_uc002sex.2_Silent_p.Q24Q|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	31					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CTGGCGAGCAGATGGCTGCCT	0.597													0	0	0	0.01441	0	178	324										A	69002384	G	A	69002384	2	1	99	1	0	0	0	0	0	0	0	1	874	933	33	1		1	ARHGAP25	2	69002384	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	6935793	69002384	174196989	44	30185										
AUP1	550	broad.mit.edu	37	chr2	74754468	74754468	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaagcagattagtgatagtCaagtctacacagccagtctt	8	9	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:74754468C>G	uc010yrx.1	-	9	1281	c.1155G>C	c.(1153-1155)TTG>TTC	p.L385F	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_Missense_Mutation_p.L61F|AUP1_uc002smf.2_Missense_Mutation_p.L328F|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.L237F|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	394	Cytoplasmic (Potential).|CUE.					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						TAGTGATAGTCAAGTCTACAC	0.527													0	0	0	0.001855	0	11	27										G	74754468	C	G	74754468	3	3	99	1	0	0	0	0	1	0	0	0	1220	825	29	1	260	1	AUP1	2	74754468	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5752084	74754468	168444905	45	30186										
MRPL19	9801	broad.mit.edu	37	chr2	75879657	75879657	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgaatttgtaggaagtattCttcgtgttactacagctgac	9	6	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:75879657C>G	uc002snl.2	+	4	374	c.349C>G	c.(349-351)CTT>GTT	p.L117V	MRPL19_uc002snm.1_Missense_Mutation_p.L117V	NM_014763	NP_055578	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19 precursor	117					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome				0						AGGAAGTATTCTTCGTGTTAC	0.383													0	0	0	0.004289	0	32	72										G	75879657	C	G	75879657	3	3	99	1	0	0	0	0	1	0	0	0	9784	913	32	1	363	1	MRPL19	2	75879657	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1125189	75879657	167319716	46	30187										
THNSL2	55258	broad.mit.edu	37	chr2	88485580	88485580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acaactggatgctgatgcttCgggacaccattgaggacctt	11	10	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:88485580C>T	uc002ssz.3	+	9	1546	c.1393C>T	c.(1393-1395)CGG>TGG	p.R465W	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_3'UTR|THNSL2_uc002ssx.3_3'UTR|THNSL2_uc002sta.3_3'UTR|THNSL2_uc002ssy.3_Missense_Mutation_p.R465W|THNSL2_uc010fhe.2_3'UTR	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	465					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						GCTGATGCTTCGGGACACCAT	0.592													0	0	0	0.009096	0	3	7										T	88485580	C	T	88485580	3	4	99	1	0	0	0	0	1	0	0	0	15860	875	31	1	1423	1	THNSL2	2	88485580	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	12605923	88485580	154713793	47	30188										
TGFBRAP1	9392	broad.mit.edu	37	chr2	105924617	105924617	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctctcctccaacaggaagtGgtagacgaagcagtcgttgg	12	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:105924617G>A	uc002tcq.2	-	2	226	c.142C>T	c.(142-144)CAC>TAC	p.H48Y	TGFBRAP1_uc002tcr.3_Missense_Mutation_p.H48Y	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	48	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						AACAGGAAGTGGTAGACGAAG	0.612													0	0	0	0.000602	0	4	42										A	105924617	G	A	105924617	3	1	99	1	0	0	0	0	1	0	0	0	15821	1348	47	2	2484	2	TGFBRAP1	2	105924617	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	17439037	105924617	137274756	48	30189										
SULT1C4	27233	broad.mit.edu	37	chr2	108994856	108994856	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagcgcttaagtgtcaactaCgtgaagggaattcttcaacc	9	9	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:108994856C>T	uc002tea.1	+	1	436	c.63C>T	c.(61-63)TAC>TAT	p.Y21Y	SULT1C4_uc002tdz.2_Silent_p.Y21Y|SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Silent_p.Y21Y	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	21					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						GTGTCAACTACGTGAAGGGAA	0.438													0	0	0	0.01441	0	61	133										T	108994856	C	T	108994856	2	4	99	1	0	0	0	0	0	0	0	1	15376	547	19	2		2	SULT1C4	2	108994856	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3070239	108994856	134204517	49	30190										
NEB	4703	broad.mit.edu	37	chr2	152381062	152381062	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttggctgcctgtgtggccttCttgatgtctggtcgatcagc	13	10	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:152381062C>G	uc010fnx.2	-	124	17429	c.17238G>C	c.(17236-17238)AAG>AAC	p.K5746N	NEB_uc002txr.2_Missense_Mutation_p.K2169N|NEB_uc002txt.3_Missense_Mutation_p.K251N	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5746	Nebulin 157.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTGTGGCCTTCTTGATGTCTG	0.498													0	0	0	0.01441	0	73	124										G	152381062	C	G	152381062	3	3	99	1	0	0	0	0	1	0	0	0	10302	912	32	1	3360	1	NEB	2	152381062	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	43386206	152381062	90818311	50	30191										
XIRP2	129446	broad.mit.edu	37	chr2	168103798	168103798	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agcagaaaacagatattcatCaggttgctgtccagaggaac	10	8	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:168103798C>T	uc002udx.2	+	8	5914	c.5896C>T	c.(5896-5898)CAG>TAG	p.Q1966*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.Q1791*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.Q1744*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1791					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATATTCATCAGGTTGCTGT	0.448													0	0	0	0.006122	0	18	20										T	168103798	C	T	168103798	4	4	99	1	0	0	0	0	0	1	0	0	17427	827	29	1	5926	1	XIRP2	2	168103798	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	15722736	168103798	75095575	51	30192										
KBTBD10	10324	broad.mit.edu	37	chr2	170356086	170356086	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	attcacttcacaaagtctatTctgccagtcccatatttgga	5	11	4	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:170356086T>C	uc010zdh.1	+	9	830	c.772T>C	c.(772-774)TCT>CCT	p.S258P	BBS5_uc002uet.2_Missense_Mutation_p.S258P|BBS5_uc010fpw.2_Missense_Mutation_p.S237P	NM_152384	NP_689597	O60662	KBTBA_HUMAN	Bardet-Biedl syndrome 5	Error:Variant_position_missing_in_O60662_after_alignment					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						CAAAGTCTATTCTGCCAGTCC	0.333													0	0	0	0.000602	0	3	120										C	170356086	T	C	170356086	3	2	99	1	0	0	0	0	1	0	0	0	7990	1783	62	5		5	KBTBD10	2	170356086	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	2252288	170356086	72843287	52	30193										
MAP1D	254042	broad.mit.edu	37	chr2	172928567	172928567	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctggcccgccacgtcctcctCttggctgggaagagtttaaa	11	13	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:172928567C>G	uc002uhk.2	+	3	400	c.327C>G	c.(325-327)CTC>CTG	p.L109L	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	109					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			ACGTCCTCCTCTTGGCTGGGA	0.488													0	0	0	0.009535	0	23	32										G	172928567	C	G	172928567	2	3	99	1	0	0	0	0	0	0	0	1	9229	900	32	1		1	MAP1D	2	172928567	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2572481	172928567	70270806	53	30194										
ASNSD1	54529	broad.mit.edu	37	chr2	190531483	190531483	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttctagggagaatattattGaagaaaatgttaatagcctg	9	3	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:190531483G>A	uc002uqt.2	+	4	1059	c.625G>A	c.(625-627)GAA>AAA	p.E209K		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	209					asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GAATATTATTGAAGAAAATGT	0.338													0	0	0	0.004007	0	15	52										A	190531483	G	A	190531483	3	1	99	1	0	0	0	0	1	0	0	0	1049	1291	45	1	627	1	ASNSD1	2	190531483	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	17602916	190531483	52667890	54	30195										
STAT1	6772	broad.mit.edu	37	chr2	191841752	191841752	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaccgcatggaagtcaggttCtaaaaaggagaaaagctaag	11	6	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:191841752C>G	uc002usj.2	-	22	2262	c.1874_splice	c.e22-1	p.E625_splice	STAT1_uc010fse.1_Splice_Site_p.E625_splice|STAT1_uc002usk.2_Splice_Site_p.E625_splice|STAT1_uc002usl.2_Splice_Site_p.E627_splice	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AAGTCAGGTTCTAAAAAGGAG	0.403													0	0	0	0.004656	0	23	45										G	191841752	C	G	191841752	5	3	99	1	0	0	0	0	0	0	1	0	15263	927	32	1	399	1	STAT1	2	191841752	Splice_Site	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1310269	191841752	51357621	55	30196										
CFLAR	8837	broad.mit.edu	37	chr2	202025318	202025318	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtgagccgaggaggctcccaGagtgtgtatggtgtggatca	17	7	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:202025318G>A	uc002uxb.3	+	9	1409	c.957G>A	c.(955-957)CAG>CAA	p.Q319Q	CFLAR_uc010zhk.1_Silent_p.Q223Q|CFLAR_uc002uxc.3_Silent_p.Q284Q|CFLAR_uc010zhl.1_Silent_p.Q223Q|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Silent_p.Q319Q|CFLAR_uc002uxf.2_Silent_p.Q319Q|CFLAR_uc010fsy.2_Intron|CFLAR_uc010fsx.2_Intron|CFLAR_uc010zhm.1_Silent_p.Q223Q|CFLAR_uc010fsz.2_Silent_p.Q74Q|CFLAR_uc002uxg.2_Silent_p.Q74Q|uc002uxh.1_5'Flank	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	319	Interaction with caspase-3.|Interaction with TRAF1 and TRAF2.|Not proteolytically processed and involved in apoptosis inhibition.|Caspase.|Interaction with caspase-8 subunits p18 and p10.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						GAGGCTCCCAGAGTGTGTATG	0.537													0	0	0	0.01441	0	42	76										A	202025318	G	A	202025318	2	1	99	1	0	0	0	0	0	0	0	1	3292	933	33	1		1	CFLAR	2	202025318	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	10183566	202025318	41174055	56	30197										
NBEAL1	65065	broad.mit.edu	37	chr2	204016211	204016211	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acagaatccaattcactggaAgctagctaatgtagagaatt	8	7	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:204016211A>T	uc002uzt.3	+	34	5732	c.5399A>T	c.(5398-5400)AAG>ATG	p.K1800M	NBEAL1_uc002uzs.3_Missense_Mutation_p.K510M	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1800							binding			ovary(1)|skin(1)	2						ATTCACTGGAAGCTAGCTAAT	0.313													0	0	0	0.010729	0	8	41										T	204016211	A	T	204016211	3	4	99	1	0	0	0	0	1	0	0	0	10188	72	3	5	5529	5	NBEAL1	2	204016211	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	1990893	204016211	39183162	57	30198										
ACCN4	55515	broad.mit.edu	37	chr2	220400035	220400035	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggaagtacaaccgcaacgaGacctacatacggtatgtgtg	11	9	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:220400035G>C	uc002vma.2	+	5	1556	c.1542G>C	c.(1540-1542)GAG>GAC	p.E514D	ACCN4_uc002vlz.2_Missense_Mutation_p.E533D|ACCN4_uc002vmb.2_Missense_Mutation_p.E187D	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	514	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		ACCGCAACGAGACCTACATAC	0.393													0	0	0	0.004482	0	9	9										C	220400035	G	C	220400035	3	2	99	1	0	0	0	0	1	0	0	0	131	933	33	1	1621	1	ACCN4	2	220400035	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	16383824	220400035	22799338	58	30199										
SP140	11262	broad.mit.edu	37	chr2	231110622	231110622	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tagatgaaggagaatcagaaGaaatgcccaagttactgcct	10	7	1	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:231110622G>T	uc002vql.2	+	7	824	c.709G>T	c.(709-711)GAA>TAA	p.E237*	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Nonsense_Mutation_p.E237*|SP140_uc002vqn.2_Nonsense_Mutation_p.E234*|SP140_uc002vqm.2_Intron|SP140_uc010fxl.2_Nonsense_Mutation_p.E237*	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	237					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGAATCAGAAGAAATGCCCAA	0.373													1	0	2.94398e-08	0.007413	3.09407e-08	11	52										T	231110622	G	T	231110622	4	4	99	1	0	0	0	0	0	1	0	0	14962	943	33	3	852	3	SP140	2	231110622	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	10710587	231110622	12088751	59	30200										
JAGN1	84522	broad.mit.edu	37	chr3	9935060	9935060	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acaggagaagaagcataaatGaagcctctttggggtgaagc	13	6	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9935060G>A	uc003btt.3	+	2	687	c.551G>A	c.(550-552)TGA>TAA	p.*184*	CIDEC_uc003bto.2_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1	184						endoplasmic reticulum membrane|integral to membrane				ovary(1)	1	Medulloblastoma(99;0.227)					AAGCATAAATGAAGCCTCTTT	0.488													0	0	0	0.009096	0	4	10										A	9935060	G	A	9935060	2	1	99	1	0	0	0	0	0	0	0	1	7936	1285	45	1		1	JAGN1	3	9935060	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		9935060	188087370	60	30201										
IL17RE	132014	broad.mit.edu	37	chr3	9956431	9956431	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaccctactgggtgttgttCtggccctcacctgccggcgc	11	16	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9956431C>G	uc003btu.2	+	16	1534	c.1417C>G	c.(1417-1419)CTG>GTG	p.L473V	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_5'Flank|IL17RC_uc011ato.1_5'Flank|IL17RC_uc010hcs.2_5'Flank|IL17RC_uc003btz.2_5'Flank|IL17RC_uc011atp.1_5'Flank|IL17RC_uc003bud.2_5'Flank|IL17RC_uc003bua.2_5'Flank|IL17RC_uc003bub.2_5'Flank|IL17RC_uc010hct.2_5'Flank|IL17RC_uc010hcu.2_5'Flank|IL17RC_uc010hcv.2_5'Flank|IL17RC_uc011atq.1_5'Flank|IL17RC_uc003buc.2_5'Flank|IL17RE_uc003btw.2_Missense_Mutation_p.L473V|IL17RE_uc003btx.2_Missense_Mutation_p.L357V|IL17RE_uc010hcq.2_Missense_Mutation_p.S497C|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	473	Helical; (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GGGTGTTGTTCTGGCCCTCAC	0.617													0	0	0	0.01441	0	49	63										G	9956431	C	G	9956431	3	3	99	1	0	0	0	0	1	0	0	0	7643	912	32	1	1475	1	IL17RE	3	9956431	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	21371	9956431	188065999	61	30202										
IL17RC	84818	broad.mit.edu	37	chr3	9974358	9974360	+	In_Frame_Del	DEL	TCC	TCC	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgccgctgcgctttccctcaTcctccttctcaaaaaggatc							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9974358_9974360delTCC	uc003bua.2	+	17	1903_1905	c.1667_1669delTCC	c.(1666-1671)ATCCTC>ATC	p.L559del	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_In_Frame_Del_p.L488del|IL17RC_uc011atp.1_In_Frame_Del_p.L327del|IL17RC_uc003bud.2_In_Frame_Del_p.L29del|IL17RC_uc003bub.2_In_Frame_Del_p.L473del|IL17RC_uc010hct.2_In_Frame_Del_p.L488del|IL17RC_uc010hcu.2_In_Frame_Del_p.L471del|IL17RC_uc010hcv.2_In_Frame_Del_p.L456del|IL17RC_uc011atq.1_In_Frame_Del_p.L473del|IL17RC_uc003buc.2_In_Frame_Del_p.L29del|IL17RC_uc003bue.2_In_Frame_Del_p.L124del|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank|CRELD1_uc003buj.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	559	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						CTTTCCCTCATCCTCCTTCTCAA	0.591											OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						54	189	---	---								-	9974360	TCC	-	9974358	7	5	99	1	0	1	0	1	0	0	0	0	7641	1435	50	0	1733	0	IL17RC	3	9974358	In_Frame_Del	DEL	TCC	TCGA-G2-A3IE-01A-11D-A20D-08	17927	9974358	188048072	62	30203										
CAND2	23066	broad.mit.edu	37	chr3	12859276	12859276	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tccagcgctgcgagggtgctGaggagggcacccggggggtg	21	10	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:12859276G>A	uc003bxk.2	+	10	2894	c.2845G>A	c.(2845-2847)GAG>AAG	p.E949K	CAND2_uc003bxj.2_Missense_Mutation_p.E856K	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	949	HEAT 20.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CGAGGGTGCTGAGGAGGGCAC	0.672													0	0	0	0.01441	0	91	57										A	12859276	G	A	12859276	3	1	99	1	0	0	0	0	1	0	0	0	2616	1291	45	1	2883	1	CAND2	3	12859276	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2884918	12859276	185163154	63	30204										
SH3BP5	9467	broad.mit.edu	37	chr3	15297659	15297659	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccctttgagcactgtagggaGagctgcttcatccggttctc	11	12	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:15297659G>A	uc003bzp.1	-	9	1491	c.1302C>T	c.(1300-1302)CTC>CTT	p.L434L	SH3BP5_uc010hem.1_RNA|SH3BP5_uc003bzq.1_Silent_p.L277L|SH3BP5_uc003bzr.1_Silent_p.L277L|uc003bzo.1_RNA	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	434				L->A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436.	intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						ACTGTAGGGAGAGCTGCTTCA	0.378													0	0	0	0.01441	0	170	150										A	15297659	G	A	15297659	2	1	99	1	0	0	0	0	0	0	0	1	14247	929	33	1		1	SH3BP5	3	15297659	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2438383	15297659	182724771	64	30205										
DYNC1LI1	51143	broad.mit.edu	37	chr3	32582547	32582547	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acctttgtgcaaactactagTactggaatgcccaagttatg	8	9	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:32582547T>C	uc003cfb.3	-	5	808	c.720A>G	c.(718-720)GTA>GTG	p.V240V	DYNC1LI1_uc011axh.1_Silent_p.V124V	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	240					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						AAACTACTAGTACTGGAATGC	0.413													0	0	0	0.004878	0	26	440										C	32582547	T	C	32582547	2	2	99	1	0	0	0	0	0	0	0	1	4844	1625	57	5		5	DYNC1LI1	3	32582547	Silent	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	17284888	32582547	165439883	65	30206										
CNOT10	25904	broad.mit.edu	37	chr3	32814971	32814971	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aatactcagctggccttacaGatcatcaaaaggaatcagct	7	10	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:32814971G>C	uc003cfc.1	+	19	2358	c.2103G>C	c.(2101-2103)CAG>CAC	p.Q701H	CNOT10_uc003cfd.1_Missense_Mutation_p.Q700H|CNOT10_uc003cfe.1_Missense_Mutation_p.Q674H|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Missense_Mutation_p.Q761H|CNOT10_uc010hfw.1_Missense_Mutation_p.Q396H	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	701					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						TGGCCTTACAGATCATCAAAA	0.443													0	0	0	0.01441	0	116	315										C	32814971	G	C	32814971	3	2	99	1	0	0	0	0	1	0	0	0	3618	933	33	1	2177	1	CNOT10	3	32814971	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	232424	32814971	165207459	66	30207										
DLEC1	9940	broad.mit.edu	37	chr3	38080973	38080973	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcttcgtctgcgcccctcctCgctgcgcacccaagatatct	8	18	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:38080973C>T	uc003cho.1	+	1	278	c.257C>T	c.(256-258)TCG>TTG	p.S86L	DLEC1_uc003chp.1_Missense_Mutation_p.S86L|DLEC1_uc010hgv.1_Missense_Mutation_p.S86L	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	86					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CGCCCCTCCTCGCTGCGCACC	0.652													0	0	0	0.009535	0	26	64										T	38080973	C	T	38080973	3	4	99	1	0	0	0	0	1	0	0	0	4552	893	31	1	259	1	DLEC1	3	38080973	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5266002	38080973	159941457	67	30208										
XIRP1	165904	broad.mit.edu	37	chr3	39228574	39228574	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggcctccatgaggatgcctCcatggtgcaggatgccaggt	15	11	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:39228574C>T	uc003cjk.1	-	2	2584	c.2363G>A	c.(2362-2364)GGA>GAA	p.G788E	XIRP1_uc003cji.2_Missense_Mutation_p.G788E|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	788							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GAGGATGCCTCCATGGTGCAG	0.622													0	0	0	0.004878	0	35	35										T	39228574	C	T	39228574	3	4	99	1	0	0	0	0	1	0	0	0	17426	855	30	1	3172	1	XIRP1	3	39228574	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1147601	39228574	158793856	68	30209										
XIRP1	165904	broad.mit.edu	37	chr3	39228623	39228623	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagagtccgcagggtcccctCagctgcagtctcctggctct	11	16	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:39228623C>T	uc003cjk.1	-	2	2535	c.2314G>A	c.(2314-2316)GAG>AAG	p.E772K	XIRP1_uc003cji.2_Missense_Mutation_p.E772K|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	772							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGGGTCCCCTCAGCTGCAGTC	0.632													0	0	0	0.013726	0	27	35										T	39228623	C	T	39228623	3	4	99	1	0	0	0	0	1	0	0	0	17426	835	29	1	3221	1	XIRP1	3	39228623	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	49	39228623	158793807	69	30210										
ZNF502	91392	broad.mit.edu	37	chr3	44763165	44763165	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atacacaccttattcatcatCagagaattcacactggtgag	6	10	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:44763165C>T	uc011baa.1	+	4	1111	c.856C>T	c.(856-858)CAG>TAG	p.Q286*	ZNF502_uc003cns.2_Nonsense_Mutation_p.Q286*|ZNF502_uc011bab.1_Nonsense_Mutation_p.Q286*|ZNF502_uc003cnt.2_Nonsense_Mutation_p.Q286*	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	286	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TATTCATCATCAGAGAATTCA	0.403													0	0	0	0.01441	0	169	261										T	44763165	C	T	44763165	4	4	99	1	0	0	0	0	0	1	0	0	17947	827	29	1	862	1	ZNF502	3	44763165	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5534542	44763165	153259265	70	30211										
USP4	7375	broad.mit.edu	37	chr3	49372916	49372916	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctatacctgaaaatagcccaGagttgtctattgggccagga	10	9	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:49372916G>A	uc003cwq.2	-	2	294	c.215C>T	c.(214-216)TCT>TTT	p.S72F	USP4_uc003cwr.2_Missense_Mutation_p.S72F	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	72	DUSP.				negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AAATAGCCCAGAGTTGTCTAT	0.453													0	0	0	0.01441	0	45	59										A	49372916	G	A	49372916	3	1	99	1	0	0	0	0	1	0	0	0	17068	942	33	1	2760	1	USP4	3	49372916	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4609751	49372916	148649514	71	30212										
HYAL1	3373	broad.mit.edu	37	chr3	50340340	50340340	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctaaagccttgggccatatcGagtaaggtcaggaagagggc	14	8	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:50340340G>T	uc003czp.2	-	2	180	c.48C>A	c.(46-48)CTC>CTA	p.L16L	HYAL1_uc003czm.2_Intron|HYAL1_uc003czo.2_Intron|HYAL1_uc003czq.2_Silent_p.L16L|HYAL1_uc003czr.2_Silent_p.L16L|HYAL1_uc003czn.2_Intron|HYAL1_uc003czs.2_Silent_p.L16L|HYAL1_uc003czt.2_Silent_p.L16L	NM_033159	NP_149349	Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1 isoform 1	16						extracellular space|lysosome	hyalurononglucosaminidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	GGGCCATATCGAGTAAGGTCA	0.627													1	0	3.01185e-09	0.003954	3.18412e-09	21	45										T	50340340	G	T	50340340	2	4	99	1	0	0	0	0	0	0	0	1	7463	1045	37	3		3	HYAL1	3	50340340	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	967424	50340340	147682090	72	30213										
DNAH1	25981	broad.mit.edu	37	chr3	52417423	52417423	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaagaacgaatccttcctgGaagatatcaacaacgtccta	6	11	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:52417423G>A	uc011bef.1	+	51	8224	c.7963G>A	c.(7963-7965)GAA>AAA	p.E2655K	DNAH1_uc003ddv.2_5'Flank	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2655	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCCTTCCTGGAAGATATCAA	0.522													0	0	0	0.008361	0	27	46										A	52417423	G	A	52417423	3	1	99	1	0	0	0	0	1	0	0	0	4597	1175	41	1	8161	1	DNAH1	3	52417423	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2077083	52417423	145605007	73	30214										
NEK4	6787	broad.mit.edu	37	chr3	52775460	52775460	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccccatctgacttatcagttGaacttgtagaagaacttaac	6	10	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:52775460G>A	uc003dfq.3	-	13	2249	c.2060C>T	c.(2059-2061)TCA>TTA	p.S687L	NEK4_uc011bej.1_Missense_Mutation_p.S598L|NEK4_uc003dfr.2_Missense_Mutation_p.S641L	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	687					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		CTTATCAGTTGAACTTGTAGA	0.328													0	0	0	0.01441	0	52	94										A	52775460	G	A	52775460	3	1	99	1	0	0	0	0	1	0	0	0	10326	1294	45	1	481	1	NEK4	3	52775460	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	358037	52775460	145246970	74	30215										
ASB14	142686	broad.mit.edu	37	chr3	57312522	57312522	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tacccatagttcagcagcatCctgagcatgacttcatcttt	6	12	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:57312522C>T	uc003diq.2	-	8	1410	c.822G>A	c.(820-822)AGG>AGA	p.R274R	ASB14_uc003dip.1_Silent_p.R153R	NM_001142733	NP_001136205	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box-containing 14	438	ANK 11.				intracellular signal transduction						0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TCAGCAGCATCCTGAGCATGA	0.453													0	0	0	0.01441	0	108	152										T	57312522	C	T	57312522	2	4	99	1	0	0	0	0	0	0	0	1	1018	854	30	1		1	ASB14	3	57312522	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4537062	57312522	140709908	75	30216										
PTPRG	5793	broad.mit.edu	37	chr3	62189597	62189597	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcggggaccgattttctgaaGacagcagatttatcactgtt	11	8	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:62189597G>C	uc003dlb.2	+	12	2847	c.2128G>C	c.(2128-2130)GAC>CAC	p.D710H	PTPRG_uc003dlc.2_Missense_Mutation_p.D710H	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	710	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATTTTCTGAAGACAGCAGATT	0.512													0	0	0	0.00632	0	20	54										C	62189597	G	C	62189597	3	2	99	1	0	0	0	0	1	0	0	0	12802	942	33	1	2174	1	PTPRG	3	62189597	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4877075	62189597	135832833	76	30217										
SYNPR	132204	broad.mit.edu	37	chr3	63542282	63542282	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaacggcagaagctggcattGattggtgactcctcgtcttc	12	10	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:63542282G>C	uc003dlq.2	+	3	582	c.213G>C	c.(211-213)TTG>TTC	p.L71F	SYNPR_uc003dlp.2_Missense_Mutation_p.L91F|SYNPR_uc011bfk.1_RNA|SYNPR_uc011bfl.1_Intron|SYNPR_uc010hnt.2_Missense_Mutation_p.L80F|SYNPR_uc011bfm.1_Intron	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	71	MARVEL.|Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		AGCTGGCATTGATTGGTGACT	0.488													0	0	0	0.013537	0	12	21										C	63542282	G	C	63542282	3	2	99	1	0	0	0	0	1	0	0	0	15456	1281	45	1	315	1	SYNPR	3	63542282	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1352685	63542282	134480148	77	30218										
ROBO1	6091	broad.mit.edu	37	chr3	78649319	78649319	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcctccaagtacctgcatttCtgcaatatttcttcgaccta	4	13	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:78649319C>G	uc003dqe.2	-	30	5093	c.4885G>C	c.(4885-4887)GAA>CAA	p.E1629Q	ROBO1_uc003dqb.2_Missense_Mutation_p.E1590Q|ROBO1_uc003dqc.2_Missense_Mutation_p.E1529Q|ROBO1_uc003dqd.2_Missense_Mutation_p.E1584Q|ROBO1_uc010hoh.2_Missense_Mutation_p.E821Q	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1629	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACCTGCATTTCTGCAATATTT	0.378													0	0	0	0.013537	0	9	28										G	78649319	C	G	78649319	3	3	99	1	0	0	0	0	1	0	0	0	13513	922	32	1	78	1	ROBO1	3	78649319	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	15107037	78649319	119373111	78	30219										
VGLL3	389136	broad.mit.edu	37	chr3	87018080	87018080	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gactcagacacagcagggggAggggctgggccagtctgatg	18	9	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:87018080A>G	uc003dqn.2	-	3	961	c.597T>C	c.(595-597)CCT>CCC	p.P199P		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAGCAGGGGGAGGGGCTGGGC	0.587													0	0	0	0.004672	0	3	153										G	87018080	A	G	87018080	2	3	99	1	0	0	0	0	0	0	0	1	17157	291	11	5		5	VGLL3	3	87018080	Silent	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	8368761	87018080	111004350	79	30220										
KIAA2018	205717	broad.mit.edu	37	chr3	113378792	113378792	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcagcctgtatgattactatCtgttgacctactgtttggtt	9	8	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:113378792C>G	uc003eam.2	-	7	2148	c.1737G>C	c.(1735-1737)CAG>CAC	p.Q579H	KIAA2018_uc003eal.2_Missense_Mutation_p.Q523H	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	579					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TGATTACTATCTGTTGACCTA	0.468													0	0	0	0.013537	0	8	159										G	113378792	C	G	113378792	3	3	99	1	0	0	0	0	1	0	0	0	8268	912	32	1	5004	1	KIAA2018	3	113378792	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	26360712	113378792	84643638	80	30221										
DRD3	1814	broad.mit.edu	37	chr3	113847752	113847752	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagggcagccagcagacaatGaaggcccctaagttgccaaa	11	11	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:113847752G>A	uc003ebd.2	-	8	1437	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	DRD3_uc010hqn.1_Silent_p.F338F|DRD3_uc003ebb.1_Silent_p.F305F|DRD3_uc003ebc.1_Silent_p.F338F	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	338	Helical; Name=6.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AGCAGACAATGAAGGCCCCTA	0.453													0	0	0	0.005524	0	32	60										A	113847752	G	A	113847752	2	1	99	1	0	0	0	0	0	0	0	1	4758	1281	45	1		1	DRD3	3	113847752	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	468960	113847752	84174678	81	30222										
MYLK	4638	broad.mit.edu	37	chr3	123419015	123419015	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acatcttgcagcttctgcttGaaggctggggctgtcccctg	12	12	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:123419015G>C	uc003ego.2	-	18	3582	c.3300C>G	c.(3298-3300)TTC>TTG	p.F1100L	MYLK_uc011bjw.1_Missense_Mutation_p.F1100L|MYLK_uc003egp.2_Missense_Mutation_p.F1031L|MYLK_uc003egq.2_Missense_Mutation_p.F1100L|MYLK_uc003egr.2_Missense_Mutation_p.F1031L|MYLK_uc003egs.2_Missense_Mutation_p.F924L|MYLK_uc003egt.2_Missense_Mutation_p.F291L	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1100	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 7.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTTCTGCTTGAAGGCTGGGG	0.532													0	0	0	0.007835	0	36	62										C	123419015	G	C	123419015	3	2	99	1	0	0	0	0	1	0	0	0	10056	1281	45	1	2512	1	MYLK	3	123419015	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	9571263	123419015	74603415	82	30223										
KALRN	8997	broad.mit.edu	37	chr3	124413237	124413237	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgcttgcttggggacacagtGatactgcagtgcaaagtctg	13	8	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:124413237G>A	uc003ehg.2	+	53	7591	c.7464G>A	c.(7462-7464)GTG>GTA	p.V2488V	KALRN_uc003ehk.2_Silent_p.V791V	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2487	Ig-like C2-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GGGACACAGTGATACTGCAGT	0.493													0	0	0	0.01441	0	48	104										A	124413237	G	A	124413237	2	1	99	1	0	0	0	0	0	0	0	1	7975	1277	45	1		1	KALRN	3	124413237	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	994222	124413237	73609193	83	30224										
HEG1	57493	broad.mit.edu	37	chr3	124739800	124739800	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atgaagtcgtggcaattctgGagtccttggggaagccttct	13	8	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:124739800G>C	uc003ehs.3	-	4	1156	c.1088C>G	c.(1087-1089)TCC>TGC	p.S363C	HEG1_uc011bke.1_Missense_Mutation_p.S363C	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	363	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GGCAATTCTGGAGTCCTTGGG	0.527													0	0	0	0.001855	0	13	32										C	124739800	G	C	124739800	3	2	99	1	0	0	0	0	1	0	0	0	7044	1174	41	1	3113	1	HEG1	3	124739800	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	326563	124739800	73282630	84	30225										
ZXDC	79364	broad.mit.edu	37	chr3	126185066	126185066	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggaggtgaagagtctgttgCaggtagaaactgggcaacgg	17	5	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:126185066C>G	uc003eiv.2	-	5	1427	c.1373G>C	c.(1372-1374)TGC>TCC	p.C458S	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.C458S	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	458	C2H2-type 10.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		GAGTCTGTTGCAGGTAGAAAC	0.572													0	0	0	0.00632	0	20	43										G	126185066	C	G	126185066	3	3	99	1	0	0	0	0	1	0	0	0	18249	710	25	4	1233	4	ZXDC	3	126185066	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1445266	126185066	71837364	85	30226										
RUVBL1	8607	broad.mit.edu	37	chr3	127800229	127800229	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttttagcaagcaagttggccGgggtcagcagctgcactgag	14	9	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:127800229G>A	uc003ekh.2	-	11	1339	c.1235C>T	c.(1234-1236)CCG>CTG	p.P412L	RUVBL1_uc003eke.2_Intron|RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Silent_p.P381P	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	412					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CAAGTTGGCCGGGGTCAGCAG	0.537													0	0	0	0.009096	0	3	48										A	127800229	G	A	127800229	3	1	99	1	0	0	0	0	1	0	0	0	13752	1116	39	2	139	2	RUVBL1	3	127800229	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1615163	127800229	70222201	86	30227										
COL6A6	131873	broad.mit.edu	37	chr3	130282479	130282479	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggatgtaataaagtacaaggAgggagcagttgatgacatct	13	4	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:130282479A>G	uc010htl.2	+	2	663	c.632A>G	c.(631-633)GAG>GGG	p.E211G		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	211	Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAGTACAAGGAGGGAGCAGTT	0.403													0	0	0	0.001168	0	4	59										G	130282479	A	G	130282479	3	3	99	1	0	0	0	0	1	0	0	0	3703	304	11	5	638	5	COL6A6	3	130282479	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	2482250	130282479	67739951	87	30228										
DNAJC13	23317	broad.mit.edu	37	chr3	132213965	132213965	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagattaggaaagcttacttCagacttgcacaaaagtacca	7	8	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:132213965C>G	uc003eor.2	+	35	4040	c.3975C>G	c.(3973-3975)TTC>TTG	p.F1325L		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1325	J.						heat shock protein binding			ovary(1)|breast(1)	2						AAGCTTACTTCAGACTTGCAC	0.378													0	0	0	0.008871	0	16	36										G	132213965	C	G	132213965	3	3	99	1	0	0	0	0	1	0	0	0	4632	825	29	1	4109	1	DNAJC13	3	132213965	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1931486	132213965	65808465	88	30229										
NMD3	51068	broad.mit.edu	37	chr3	160968072	160968072	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagattttcttgaagatcttGaagaagatgaggcaattcga	10	4	2	7			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:160968072G>A	uc003feb.1	+	15	1458	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	NMD3_uc003fec.2_Missense_Mutation_p.E447K|NMD3_uc003fed.1_Missense_Mutation_p.E447K	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	447	Necessary for the nuclear export of the 60S ribosomal subunit.				protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TGAAGATCTTGAAGAAGATGA	0.279													0	0	0	0.003954	0	16	30										A	160968072	G	A	160968072	3	1	99	1	0	0	0	0	1	0	0	0	10488	1291	45	1	1393	1	NMD3	3	160968072	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	28754107	160968072	37054358	89	30230										
GHSR	2693	broad.mit.edu	37	chr3	172165775	172165775	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggagtgggaagcagatggcGaagtagcgctcgacgctcag	17	9	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:172165775G>A	uc003fib.1	-	1	429	c.429C>T	c.(427-429)TTC>TTT	p.F143F	GHSR_uc011bpv.1_Silent_p.F143F	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	143	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGCAGATGGCGAAGTAGCGCT	0.627													0	0	0	0.008291	0	10	29										A	172165775	G	A	172165775	2	1	99	1	0	0	0	0	0	0	0	1	6375	1049	37	1		1	GHSR	3	172165775	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	11197703	172165775	25856655	90	30231										
EHHADH	1962	broad.mit.edu	37	chr3	184922354	184922354	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caaaagatatagaaacagctCctcctccttcttgatgccca	5	13	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:184922354C>T	uc003fpf.2	-	6	787	c.760G>A	c.(760-762)GAG>AAG	p.E254K	EHHADH_uc011brs.1_Missense_Mutation_p.E158K	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	254	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	AGAAACAGCTCCTCCTCCTTC	0.537													0	0	0	0.01441	0	44	104										T	184922354	C	T	184922354	3	4	99	1	0	0	0	0	1	0	0	0	4982	864	30	1	1419	1	EHHADH	3	184922354	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	12756579	184922354	13100076	91	30232										
ATP13A3	79572	broad.mit.edu	37	chr3	194159590	194159590	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	taagtgatttctcaccatttCttggtttcctgcaggggtag	10	8	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:194159590C>G	uc003fty.3	-	16	2224	c.1822G>C	c.(1822-1824)GAA>CAA	p.E608Q	ATP13A3_uc003ftz.1_Missense_Mutation_p.E314Q	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	608					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CTCACCATTTCTTGGTTTCCT	0.318													0	0	0	0.01441	0	40	94										G	194159590	C	G	194159590	3	3	99	1	0	0	0	0	1	0	0	0	1125	922	32	1	1926	1	ATP13A3	3	194159590	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9237236	194159590	3862840	92	30233										
MUC20	200958	broad.mit.edu	37	chr3	195451911	195451911	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctttgacaccctttgcaccgAtgacagctctgaagaggcaa	9	12	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:195451911A>C	uc010hzo.2	+	2	563	c.437A>C	c.(436-438)GAT>GCT	p.D146A	MUC20_uc010hzp.2_Missense_Mutation_p.D111A|MUC20_uc011bte.1_5'Flank	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CTTTGCACCGATGACAGCTCT	0.557													0	0	0	0.01441	0	17	343										C	195451911	A	C	195451911	3	2	99	1	0	0	0	0	1	0	0	0	9976	333	12	5	443	5	MUC20	3	195451911	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	1292321	195451911	2570519	93	30234										
LMLN	89782	broad.mit.edu	37	chr3	197701923	197701923	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttattttcaggttgctccctGagaaaaagaatcttgtaaag	8	6	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:197701923G>A	uc011buo.1	+	3	350	c.328G>A	c.(328-330)GAG>AAG	p.E110K	LMLN_uc003fyt.2_Missense_Mutation_p.E58K|LMLN_uc010iar.2_Missense_Mutation_p.E110K|LMLN_uc010ias.2_Missense_Mutation_p.E58K|LMLN_uc003fyu.2_5'UTR	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	110					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GTTGCTCCCTGAGAAAAAGAA	0.164													0	0	0	0.004878	0	28	69										A	197701923	G	A	197701923	3	1	99	1	0	0	0	0	1	0	0	0	8847	1291	45	1	338	1	LMLN	3	197701923	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2250012	197701923	320507	94	30235										
MFSD7	84179	broad.mit.edu	37	chr4	675782	675782	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggggaggagaaggaggagtGagacccagccgggtcaataa	18	7	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:675782G>A	uc003gay.2	-	10	1705	c.1648C>T	c.(1648-1650)CAC>TAC	p.H550Y	MYL5_uc003gat.2_RNA|MYL5_uc003gau.2_RNA|MYL5_uc003gav.2_Silent_p.*174*|MFSD7_uc003gaw.2_Missense_Mutation_p.H292Y|MFSD7_uc003gax.2_Missense_Mutation_p.H549Y|MFSD7_uc003gaz.2_Missense_Mutation_p.H431Y|MFSD7_uc003gba.2_Missense_Mutation_p.H453Y|MFSD7_uc003gbb.1_3'UTR	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	550					transmembrane transport	integral to membrane					0						AAGGAGGAGTGAGACCCAGCC	0.657													0	0	0	0.00308	0	5	24										A	675782	G	A	675782	3	1	99	1	0	0	0	0	1	0	0	0	9537	1294	45	1	38	1	MFSD7	4	675782	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		675782	190478494	95	30236										
GSX2	170825	broad.mit.edu	37	chr4	54968002	54968002	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcgggctgcaagtgcgtcggGagccaggtgcactacgcgcg	18	12	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:54968002G>C	uc010igp.1	+	2	1092	c.828G>C	c.(826-828)GGG>GGC	p.G276G	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	276						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AGTGCGTCGGGAGCCAGGTGC	0.607													0	0	0	0.006214	0	10	25										C	54968002	G	C	54968002	2	2	99	1	0	0	0	0	0	0	0	1	6850	1161	41	1		1	GSX2	4	54968002	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	54292220	54968002	136186274	96	30237										
LPHN3	23284	broad.mit.edu	37	chr4	62758676	62758676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catgccctgcaggaactataGgtaagtctgtgctaaagcac	10	10	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:62758676G>A	uc010ihh.2	+	7	1752	c.1579G>A	c.(1579-1581)GGT>AGT	p.G527S	LPHN3_uc003hcq.3_Missense_Mutation_p.G527S|LPHN3_uc003hcs.1_Missense_Mutation_p.G356S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	527	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AGGAACTATAGGTAAGTCTGT	0.353													0	0	0	0.004672	0	2	5										A	62758676	G	A	62758676	3	1	99	1	0	0	0	0	1	0	0	0	8917	1014	35	2	1605	2	LPHN3	4	62758676	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7790674	62758676	128395600	97	30238										
ALB	213	broad.mit.edu	37	chr4	74279157	74279157	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcggaccttgccaagtatatCtgtgaaaatcaagattcgat	9	8	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:74279157C>T	uc003hgs.3	+	8	937	c.864C>T	c.(862-864)ATC>ATT	p.I288I	ALB_uc003hgw.3_Silent_p.I96I|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Silent_p.I288I|ALB_uc010iii.2_Silent_p.I173I|ALB_uc003hgu.3_Silent_p.I138I|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Silent_p.I178I|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	288	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CCAAGTATATCTGTGAAAATC	0.403													0	0	0	0.00623	0	31	44										T	74279157	C	T	74279157	2	4	99	1	0	0	0	0	0	0	0	1	486	903	32	1		1	ALB	4	74279157	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	11520481	74279157	116875119	98	30239										
SEPT11	55752	broad.mit.edu	37	chr4	77917662	77917662	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggtcaacaagtctacttctCaaggattctgtttcaacatc	6	10	5	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:77917662C>G	uc003hkj.2	+	2	274	c.112C>G	c.(112-114)CAA>GAA	p.Q38E	SEPT11_uc010ijh.1_Missense_Mutation_p.Q30E|SEPT11_uc011cca.1_Missense_Mutation_p.Q48E	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	38					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						GTCTACTTCTCAAGGATTCTG	0.438													0	0	0	0.004007	0	10	60										G	77917662	C	G	77917662	3	3	99	1	0	0	0	0	1	0	0	0	14061	827	29	1	118	1	SEPT11	4	77917662	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3638505	77917662	113236614	99	30240										
HNRPDL	9987	broad.mit.edu	37	chr4	83350483	83350483	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gctgtactcgttcatatcctCcatagtgacggagctgtcgg	11	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:83350483C>G	uc003hmr.2	-	1	896	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.E121Q	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	121					regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				TTCATATCCTCCATAGTGACG	0.587													0	0	0	0.01441	0	67	63										G	83350483	C	G	83350483	3	3	99	1	0	0	0	0	1	0	0	0	7276	864	30	1	929	1	HNRPDL	4	83350483	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5432821	83350483	107803793	100	30241										
AFF1	4299	broad.mit.edu	37	chr4	87967934	87967934	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agttccttagtactaagtctCacactcatcgcctggatgct	7	12	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:87967934C>T	uc003hqj.3	+	3	633	c.226C>T	c.(226-228)CAC>TAC	p.H76Y	AFF1_uc011ccx.1_Missense_Mutation_p.H17Y|AFF1_uc003hqh.1_Missense_Mutation_p.H83Y|AFF1_uc011ccy.1_Missense_Mutation_p.H83Y|AFF1_uc011ccz.1_Missense_Mutation_p.H83Y|AFF1_uc003hqk.3_Missense_Mutation_p.H76Y|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	76						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TACTAAGTCTCACACTCATCG	0.438													0	0	0	0.01441	0	70	275										T	87967934	C	T	87967934	3	4	99	1	0	0	0	0	1	0	0	0	356	826	29	1	278	1	AFF1	4	87967934	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4617451	87967934	103186342	101	30242										
AFF1	4299	broad.mit.edu	37	chr4	88036278	88036278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgctcagggacactcctcccCcacaaagcttgatggtgaag	10	14	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:88036278C>T	uc003hqj.3	+	11	2679	c.2272C>T	c.(2272-2274)CCA>TCA	p.P758S	AFF1_uc011ccz.1_Missense_Mutation_p.P765S|AFF1_uc003hqk.3_Missense_Mutation_p.P758S|AFF1_uc011cda.1_Missense_Mutation_p.P396S	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	758						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CACTCCTCCCCCACAAAGCTT	0.597													0	0	0	0.01441	0	50	90										T	88036278	C	T	88036278	3	4	99	1	0	0	0	0	1	0	0	0	356	623	22	2	2356	2	AFF1	4	88036278	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	68344	88036278	103117998	102	30243										
GLRB	2743	broad.mit.edu	37	chr4	158091590	158091590	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atatttattcttaggttggtGagaccagatgcaaaaaagtt	9	4	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:158091590G>A	uc003ipj.2	+	10	1406	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	402	Cytoplasmic (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TTAGGTTGGTGAGACCAGATG	0.308													0	0	0	0.012319	0	17	7										A	158091590	G	A	158091590	3	1	99	1	0	0	0	0	1	0	0	0	6458	1294	45	1	1238	1	GLRB	4	158091590	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	70055312	158091590	33062686	103	30244										
KIAA0947	23379	broad.mit.edu	37	chr5	5465303	5465303	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccgtaatgagagatcaagaGaaggaagttgtttatgaatt	11	4	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:5465303G>C	uc003jdm.3	+	13	6078	c.5856G>C	c.(5854-5856)GAG>GAC	p.E1952D		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1952										ovary(1)|central_nervous_system(1)	2						GAGATCAAGAGAAGGAAGTTG	0.368													0	0	0	0.004672	0	2	6										C	5465303	G	C	5465303	3	2	99	1	0	0	0	0	1	0	0	0	8202	933	33	1	5906	1	KIAA0947	5	5465303	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		5465303	175449957	104	30245										
PRDM9	56979	broad.mit.edu	37	chr5	23527167	23527167	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctcctcactcaccagaggaGacacacaggggagaagccct	10	15	2	3	rs112679149		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:23527167G>C	uc003jgo.2	+	11	2152	c.1970G>C	c.(1969-1971)AGA>ACA	p.R657T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	657	C2H2-type 6.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CACCAGAGGAGACACACAGGG	0.607										HNSCC(3;0.000094)			0	0	0	0.000602	0	3	109										C	23527167	G	C	23527167	3	2	99	1	0	0	0	0	1	0	0	0	12463	942	33	1	2008	1	PRDM9	5	23527167	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	18061864	23527167	157388093	105	30246										
C5orf42	65250	broad.mit.edu	37	chr5	37115115	37115115	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcttactgctgctttggctCcaccagcttttttctgtatg	7	11	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:37115115C>A	uc011cpa.1	-	50	9416	c.9185G>T	c.(9184-9186)GGA>GTA	p.G3062V	C5orf42_uc003jko.1_Missense_Mutation_p.G93V|C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Missense_Mutation_p.G1580V|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.G2155V	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	3062										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGCTTTGGCTCCACCAGCTTT	0.348													1	0	1.55795e-14	0.012319	1.67012e-14	19	14										A	37115115	C	A	37115115	3	1	99	1	0	0	0	0	1	0	0	0	2301	855	30	3	420	3	C5orf42	5	37115115	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	13587948	37115115	143800145	106	30247										
MRPS30	10884	broad.mit.edu	37	chr5	44809390	44809390	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgaccgctggtaccagtactTcaccaagaccgtgttcctgt	9	14	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:44809390T>A	uc003joh.2	+	1	364	c.326T>A	c.(325-327)TTC>TAC	p.F109Y	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	109					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TACCAGTACTTCACCAAGACC	0.498													0	0	0	0.00632	0	21	25										A	44809390	T	A	44809390	3	1	99	1	0	0	0	0	1	0	0	0	9840	1783	62	5	328	5	MRPS30	5	44809390	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	7694275	44809390	136105870	107	30248										
MSH3	4437	broad.mit.edu	37	chr5	79965995	79965995	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acagaaaactgcttccaaatCagctaacaaacggtccaaaa	5	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:79965995C>A	uc003kgz.2	+	4	912	c.659C>A	c.(658-660)TCA>TAA	p.S220*		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	220	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GCTTCCAAATCAGCTAACAAA	0.378								MMR					1	0	0.00010058	0.013537	0.000102687	13	13										A	79965995	C	A	79965995	4	1	99	1	0	0	0	0	0	1	0	0	9871	838	29	3	673	3	MSH3	5	79965995	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	35156605	79965995	100949265	108	30249										
GPR98	84059	broad.mit.edu	37	chr5	90124866	90124866	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agattaaaatcttagaaagtGatgaatctcaaagccttgtg	8	5	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90124866G>A	uc003kju.2	+	77	16570	c.16474G>A	c.(16474-16476)GAT>AAT	p.D5492N	GPR98_uc003kjt.2_Missense_Mutation_p.D3198N|GPR98_uc003kjw.2_Missense_Mutation_p.D1153N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5492	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTAGAAAGTGATGAATCTCA	0.433													0	0	0	0.00874	0	35	34										A	90124866	G	A	90124866	3	1	99	1	0	0	0	0	1	0	0	0	6721	1290	45	1	16780	1	GPR98	5	90124866	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	10158871	90124866	90790394	109	30250										
GPR98	84059	broad.mit.edu	37	chr5	90124959	90124959	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcagtctgcaggtggccagaGattctgggacaggactaatg	14	8	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90124959G>T	uc003kju.2	+	77	16663	c.16567G>T	c.(16567-16569)GAT>TAT	p.D5523Y	GPR98_uc003kjt.2_Missense_Mutation_p.D3229Y|GPR98_uc003kjw.2_Missense_Mutation_p.D1184Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5523	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGTGGCCAGAGATTCTGGGAC	0.418													1	0	5.10314e-47	0.01441	5.65142e-47	75	53										T	90124959	G	T	90124959	3	4	99	1	0	0	0	0	1	0	0	0	6721	942	33	3	16873	3	GPR98	5	90124959	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	93	90124959	90790301	110	30251										
ARRDC3	57561	broad.mit.edu	37	chr5	90678672	90678672	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtctttatggttgaaatactCtacttcttcagtgtaattct	6	7	5	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90678672C>G	uc003kjz.2	-	1	478	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	LOC100129716_uc003kka.3_Intron	NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	80					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		TTGAAATACTCTACTTCTTCA	0.378													0	0	0	0.01441	0	44	40										G	90678672	C	G	90678672	3	3	99	1	0	0	0	0	1	0	0	0	984	922	32	1	1038	1	ARRDC3	5	90678672	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	553713	90678672	90236588	111	30252										
SHROOM1	134549	broad.mit.edu	37	chr5	132160501	132160501	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tacatcaccgcagcctctttCtgaggcaagaacctggaggc	10	13	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:132160501C>G	uc003kxx.2	-	6	1852	c.1047G>C	c.(1045-1047)CAG>CAC	p.Q349H	SHROOM1_uc003kxy.1_Missense_Mutation_p.Q349H	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	349					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGCCTCTTTCTGAGGCAAGA	0.542													0	0	0	0.000602	0	4	22										G	132160501	C	G	132160501	3	3	99	1	0	0	0	0	1	0	0	0	14293	912	32	1	1531	1	SHROOM1	5	132160501	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	41481829	132160501	48754759	112	30253										
SEC24A	10802	broad.mit.edu	37	chr5	134044472	134044472	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agtgaatgcagtcattgactCcctttcagcttaccgttctt	7	11	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:134044472C>G	uc003kzs.2	+	18	2909	c.2621C>G	c.(2620-2622)TCC>TGC	p.S874C	SEC24A_uc011cxu.1_Missense_Mutation_p.S638C	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	874					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCATTGACTCCCTTTCAGCT	0.468													0	0	0	0.004878	0	33	46										G	134044472	C	G	134044472	3	3	99	1	0	0	0	0	1	0	0	0	13994	855	30	1	2691	1	SEC24A	5	134044472	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1883971	134044472	46870788	113	30254										
ETF1	2107	broad.mit.edu	37	chr5	137846256	137846256	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagaaaataatcacatacctCtttgtctgtgaaatgagatt	6	6	3	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:137846256C>G	uc003ldc.3	-	9	1246	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q	ETF1_uc011cyv.1_Missense_Mutation_p.E347Q|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Missense_Mutation_p.E328Q	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	361					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCACATACCTCTTTGTCTGTG	0.398													0	0	0	0.004482	0	6	40										G	137846256	C	G	137846256	3	3	99	1	0	0	0	0	1	0	0	0	5268	922	32	1	244	1	ETF1	5	137846256	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3801784	137846256	43069004	114	30255										
CTNNA1	1495	broad.mit.edu	37	chr5	138269620	138269620	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtatggcttccctcaaccttCctgctgtgtcatggaagatg	10	11	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:138269620C>G	uc003ldh.2	+	18	2658	c.2563C>G	c.(2563-2565)CCT>GCT	p.P855A	CTNNA1_uc011cyx.1_Missense_Mutation_p.P752A|CTNNA1_uc011cyy.1_Missense_Mutation_p.P732A|CTNNA1_uc003ldi.2_Missense_Mutation_p.P553A|CTNNA1_uc003ldj.2_3'UTR|CTNNA1_uc003ldl.2_Missense_Mutation_p.P485A	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	855					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCTCAACCTTCCTGCTGTGTC	0.478													0	0	0	0.000602	0	3	39										G	138269620	C	G	138269620	3	3	99	1	0	0	0	0	1	0	0	0	4012	855	30	1	2629	1	CTNNA1	5	138269620	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	423364	138269620	42645640	115	30256										
SH3RF2	153769	broad.mit.edu	37	chr5	145317639	145317639	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccacaaagagctgcggtgcCccgaatgcaggacgcctgtg	13	14	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:145317639C>T	uc003lnt.2	+	2	386	c.148C>T	c.(148-150)CCC>TCC	p.P50S	SH3RF2_uc011dbl.1_Missense_Mutation_p.P50S	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	50	RING-type.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGCGGTGCCCCGAATGCAG	0.592													0	0	0	0.009096	0	4	37										T	145317639	C	T	145317639	3	4	99	1	0	0	0	0	1	0	0	0	14259	623	22	2	150	2	SH3RF2	5	145317639	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	7048019	145317639	35597621	116	30257										
TLX3	30012	broad.mit.edu	37	chr5	170736430	170736430	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agcccatcagcttcggcatcGaccagatccttaacagcccg	8	16	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:170736430G>T	uc003mbf.2	+	1	143	c.61G>T	c.(61-63)GAC>TAC	p.D21Y	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTCGGCATCGACCAGATCCT	0.781			T	BCL11B	T-ALL								1	0	5.18039e-06	0.00308	5.35008e-06	6	9										T	170736430	G	T	170736430	3	4	99	1	0	0	0	0	1	0	0	0	15959	1058	37	3	63	3	TLX3	5	170736430	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	25418791	170736430	10178830	117	30258										
BTNL8	79908	broad.mit.edu	37	chr5	180338519	180338519	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggcctgtttgatgtggagaTctctctgaccgtccaagaga	12	9	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:180338519T>G	uc003mmp.2	+	3	812	c.578T>G	c.(577-579)ATC>AGC	p.I193S	BTNL8_uc003mmq.2_Missense_Mutation_p.I193S|BTNL8_uc011dhg.1_Missense_Mutation_p.I68S|BTNL8_uc010jll.2_Missense_Mutation_p.I193S|BTNL8_uc010jlm.2_Missense_Mutation_p.I77S|BTNL8_uc011dhh.1_Missense_Mutation_p.I9S	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	193	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGTGGAGATCTCTCTGACC	0.552													0	0	0	0.004878	0	31	36										G	180338519	T	G	180338519	3	3	99	1	0	0	0	0	1	0	0	0	1567	1435	50	5	614	5	BTNL8	5	180338519	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	9602089	180338519	576741	118	30259										
DUSP22	56940	broad.mit.edu	37	chr6	348771	348771	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtttccatcctctccagtaTcggcagtggctgaaggaaga	11	10	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:348771T>C	uc003msx.2	+	7	877	c.438T>C	c.(436-438)TAT>TAC	p.Y146Y	DUSP22_uc011dhn.1_Silent_p.Y146Y|DUSP22_uc003msy.1_Silent_p.Y103Y	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	146					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CTCTCCAGTATCGGCAGTGGC	0.517													0	0	0	0.001984	0	5	107										C	348771	T	C	348771	2	2	99	1	0	0	0	0	0	0	0	1	4821	1442	50	5		5	DUSP22	6	348771	Silent	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08		348771	170766296	119	30260										
CDYL	9425	broad.mit.edu	37	chr6	4943831	4943831	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagcccattattgtagcagtCaatggcccagccattggtct	9	11	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:4943831C>T	uc003mwi.2	+	7	1466	c.1335C>T	c.(1333-1335)GTC>GTT	p.V445V	CDYL_uc003mwj.2_Silent_p.V391V|CDYL_uc003mwk.2_Silent_p.V156V|CDYL_uc011dhx.1_Silent_p.V259V|CDYL_uc011dhy.1_Silent_p.V259V	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	445					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		TTGTAGCAGTCAATGGCCCAG	0.383													0	0	0	0.00308	0	6	83										T	4943831	C	T	4943831	2	4	99	1	0	0	0	0	0	0	0	1	3185	813	29	1		1	CDYL	6	4943831	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4595060	4943831	166171236	120	30261										
F13A1	2162	broad.mit.edu	37	chr6	6224981	6224981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggactggattctcagagctcCggtattccaatagaatgtca	10	9	2	2	rs139164988		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:6224981C>T	uc003mwv.2	-	7	1034	c.911G>A	c.(910-912)CGG>CAG	p.R304Q	F13A1_uc011dib.1_Missense_Mutation_p.R241Q	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	304					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTCAGAGCTCCGGTATTCCAA	0.463													0	0	0	0.013114	0	38	73										T	6224981	C	T	6224981	3	4	99	1	0	0	0	0	1	0	0	0	5340	652	23	2	1323	2	F13A1	6	6224981	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1281150	6224981	164890086	121	30262										
LY86	9450	broad.mit.edu	37	chr6	6589066	6589066	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggcccacacacgtggtctgTagcgacagcggcttggaagt	14	11	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:6589066T>A	uc003mwy.1	+	1	133	c.99T>A	c.(97-99)TGT>TGA	p.C33*	LOC285780_uc003mww.3_Intron|LOC285780_uc003mwx.2_Intron	NM_004271	NP_004262	O95711	LY86_HUMAN	MD-1, RP105-associated precursor	33					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane					0	Ovarian(93;0.0377)					ACGTGGTCTGTAGCGACAGCG	0.572													0	0	0	0.008291	0	9	62										A	6589066	T	A	6589066	4	1	99	1	0	0	0	0	0	1	0	0	9100	1644	57	5	101	5	LY86	6	6589066	Nonsense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	364085	6589066	164526001	122	30263										
SYCP2L	221711	broad.mit.edu	37	chr6	10891745	10891745	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acatgtttttattccacacaGaaaaacaaagatgctttgca	5	8	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:10891745G>C	uc003mzo.2	+	2	306	c.10_splice	c.e2-1	p.K4_splice	SYCP2L_uc011dim.1_Splice_Site	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like							nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			ATTCCACACAGAAAAACAAAG	0.299													0	0	0	0.004482	0	5	57										C	10891745	G	C	10891745	5	2	99	1	0	0	0	0	0	0	1	0	15430	956	33	1	15	1	SYCP2L	6	10891745	Splice_Site	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4302679	10891745	160223322	123	30264										
SYCP2L	221711	broad.mit.edu	37	chr6	10912908	10912908	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgaaatgatctcttacagatGagaaaaccagcggatgaaaa	9	6	1	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:10912908G>A	uc003mzo.2	+	13	1217	c.921G>A	c.(919-921)ATG>ATA	p.M307I	SYCP2L_uc011din.1_Missense_Mutation_p.M148I|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	307						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TCTTACAGATGAGAAAACCAG	0.343													0	0	0	0.00245	0	12	51										A	10912908	G	A	10912908	3	1	99	1	0	0	0	0	1	0	0	0	15430	1290	45	1	971	1	SYCP2L	6	10912908	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	21163	10912908	160202159	124	30265										
OR2B6	26212	broad.mit.edu	37	chr6	27925119	27925119	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccttgtggtcttcttgatttCttacactgtgaccatctttg	7	10	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925119C>G	uc011dkx.1	+	1	101	c.101C>G	c.(100-102)TCT>TGT	p.S34C		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCTTGATTTCTTACACTGTG	0.418													0	0	0	0.012319	0	21	65										G	27925119	C	G	27925119	3	3	99	1	0	0	0	0	1	0	0	0	10991	913	32	1	103	1	OR2B6	6	27925119	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	17012211	27925119	143189948	125	30266			1	131		3	3	726	C		5.555932e-05
OR2B6	26212	broad.mit.edu	37	chr6	27925668	27925668	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctgacactcatccttatatCatatgcttttattgtccgag	5	11	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925668C>T	uc011dkx.1	+	1	650	c.650C>T	c.(649-651)TCA>TTA	p.S217L		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATCCTTATATCATATGCTTTT	0.423													0	0	0	0.01441	0	40	169										T	27925668	C	T	27925668	3	4	99	1	0	0	0	0	1	0	0	0	10991	838	29	1	652	1	OR2B6	6	27925668	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	549	27925668	143189399	126	30267			1	131		3	3	726	C		5.555932e-05
OR2B6	26212	broad.mit.edu	37	chr6	27925844	27925844	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accaaggaaagatggtttctCtcttctatggaatcattgca	8	8	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925844C>T	uc011dkx.1	+	1	826	c.826C>T	c.(826-828)CTC>TTC	p.L276F		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GATGGTTTCTCTCTTCTATGG	0.438													0	0	0	0.004007	0	14	67										T	27925844	C	T	27925844	3	4	99	1	0	0	0	0	1	0	0	0	10991	913	32	1	828	1	OR2B6	6	27925844	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	176	27925844	143189223	127	30268			1	131		3	3	726	C		5.555932e-05
ZKSCAN3	80317	broad.mit.edu	37	chr6	28333556	28333556	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acactggtgagaagccatatGagtgtgaagaatgtggtaag	14	4	0	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:28333556G>A	uc003nle.3	+	6	1327	c.1111G>A	c.(1111-1113)GAG>AAG	p.E371K	ZKSCAN3_uc010jrc.2_Missense_Mutation_p.E371K|ZKSCAN3_uc003nlf.3_Missense_Mutation_p.E223K|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	371	C2H2-type 3.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GAAGCCATATGAGTGTGAAGA	0.493													0	0	0	0.001168	0	5	80										A	28333556	G	A	28333556	3	1	99	1	0	0	0	0	1	0	0	0	17685	1291	45	1	1129	1	ZKSCAN3	6	28333556	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	407712	28333556	142781511	128	30269										
OR2W1	26692	broad.mit.edu	37	chr6	29012734	29012734	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgagggatgatgctggttgtGaaacatagatctaggaaaga	14	3	1	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:29012734G>C	uc003nlw.2	-	1	219	c.219C>G	c.(217-219)TTC>TTG	p.F73L		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGCTGGTTGTGAAACATAGAT	0.428													0	0	0	0.000602	0	4	63										C	29012734	G	C	29012734	3	2	99	1	0	0	0	0	1	0	0	0	11032	1281	45	1	747	1	OR2W1	6	29012734	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	679178	29012734	142102333	129	30270										
NFKBIL1	4795	broad.mit.edu	37	chr6	31516038	31516038	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctggtccgggcccaggccctCctccagcgacacccaggcct	11	20	0	0	rs144376753		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31516038C>T	uc003nub.2	+	2	275	c.156C>T	c.(154-156)CTC>CTT	p.L52L	BAT1_uc003ntv.2_5'Flank|ATP6V1G2_uc003ntz.2_5'Flank|ATP6V1G2_uc003nua.2_5'Flank|NFKBIL1_uc011dnr.1_Silent_p.L29L|NFKBIL1_uc011dns.1_Silent_p.L29L|NFKBIL1_uc011dnt.1_RNA|NFKBIL1_uc003nuc.2_Silent_p.L52L	NM_005007	NP_004998	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene	52					cytoplasmic sequestering of transcription factor		protein binding				0						CCCAGGCCCTCCTCCAGCGAC	0.677													0	0	0	0.003954	0	19	17										T	31516038	C	T	31516038	2	4	99	1	0	0	0	0	0	0	0	1	10381	842	30	1		1	NFKBIL1	6	31516038	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2503304	31516038	139599029	130	30271										
MSH5	4439	broad.mit.edu	37	chr6	31708290	31708290	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaggacaccgcagggaccgaGacctggggcggcctcctccg	16	15	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31708290G>A	uc003nwv.1	+	2	126	c.47G>A	c.(46-48)AGA>AAA	p.R16K	MSH5_uc003nwt.1_Missense_Mutation_p.R16K|MSH5_uc003nwu.1_Missense_Mutation_p.R16K|MSH5_uc003nww.1_Missense_Mutation_p.R16K|MSH5_uc003nwx.1_Missense_Mutation_p.R16K	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	16					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CAGGGACCGAGACCTGGGGCG	0.582								Direct_reversal_of_damage|MMR					0	0	0	0.001168	0	3	5										A	31708290	G	A	31708290	3	1	99	1	0	0	0	0	1	0	0	0	9873	942	33	1	49	1	MSH5	6	31708290	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	192252	31708290	139406777	131	30272										
MSH5	4439	broad.mit.edu	37	chr6	31721100	31721100	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tatggttcacacgtccgactCatgacctgggggagctcagt	12	11	3	1	rs142533600		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31721100C>T	uc003nwv.1	+	11	914	c.835C>T	c.(835-837)CAT>TAT	p.H279Y	MSH5_uc003nwt.1_Missense_Mutation_p.H296Y|MSH5_uc003nwu.1_Missense_Mutation_p.H279Y|MSH5_uc003nww.1_Missense_Mutation_p.H279Y|MSH5_uc003nwx.1_Missense_Mutation_p.H296Y|MSH5_uc011dof.1_5'UTR|MSH5_uc003nwy.1_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	279					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						ACGTCCGACTCATGACCTGGG	0.512								Direct_reversal_of_damage|MMR					0	0	0	0.01441	0	104	73										T	31721100	C	T	31721100	3	4	99	1	0	0	0	0	1	0	0	0	9873	826	29	1	924	1	MSH5	6	31721100	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	12810	31721100	139393967	132	30273										
C6orf10	10665	broad.mit.edu	37	chr6	32261066	32261066	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtttctggtacactcacctCagtgttctttacttgggatt	8	9	4	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:32261066C>G	uc011dpy.1	-	12	1557	c.1384G>C	c.(1384-1386)GAG>CAG	p.E462Q	C6orf10_uc011dpx.1_Missense_Mutation_p.E244Q	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	462						integral to membrane				skin(1)	1						ACACTCACCTCAGTGTTCTTT	0.453													0	0	0	0.013537	0	10	233										G	32261066	C	G	32261066	3	3	99	1	0	0	0	0	1	0	0	0	2317	835	29	1	311	1	C6orf10	6	32261066	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	539966	32261066	138854001	133	30274										
SYNGAP1	8831	broad.mit.edu	37	chr6	33393617	33393617	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accggaggagcgagtccagtCgcaacaaactgctgagacgc	13	12	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:33393617C>G	uc011dri.1	+	3	427	c.232C>G	c.(232-234)CGC>GGC	p.R78G	SYNGAP1_uc003oeo.1_Missense_Mutation_p.R63G|SYNGAP1_uc010juy.2_Missense_Mutation_p.R63G	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	78					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CGAGTCCAGTCGCAACAAACT	0.692													0	0	0	0.013114	0	34	52										G	33393617	C	G	33393617	3	3	99	1	0	0	0	0	1	0	0	0	15444	884	31	1	242	1	SYNGAP1	6	33393617	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1132551	33393617	137721450	134	30275										
SYNGAP1	8831	broad.mit.edu	37	chr6	33408987	33408987	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	actttctgggcttcatgaatGagtttctggagctggaatgg	13	6	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:33408987G>T	uc011dri.1	+	12	2146	c.1951G>T	c.(1951-1953)GAG>TAG	p.E651*	SYNGAP1_uc010juy.2_Nonsense_Mutation_p.E636*|SYNGAP1_uc010juz.2_Nonsense_Mutation_p.E363*	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	651					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CTTCATGAATGAGTTTCTGGA	0.373													1	0	2.18419e-29	0.01441	2.40396e-29	45	32										T	33408987	G	T	33408987	4	4	99	1	0	0	0	0	0	1	0	0	15444	1291	45	3	1997	3	SYNGAP1	6	33408987	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	15370	33408987	137706080	135	30276										
GRM4	2914	broad.mit.edu	37	chr6	34059676	34059676	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaccgtcctcacgggacttCtggatgaaggcctccacacc	9	16	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34059676C>T	uc003oir.3	-	2	890	c.720G>A	c.(718-720)CAG>CAA	p.Q240Q	GRM4_uc011dsn.1_Silent_p.Q240Q|GRM4_uc010jvh.2_Silent_p.Q240Q|GRM4_uc010jvi.2_Intron|GRM4_uc010jvk.1_Silent_p.Q159Q|GRM4_uc011dsl.1_Silent_p.Q100Q|GRM4_uc003oiq.2_Silent_p.Q107Q|GRM4_uc011dsm.1_Silent_p.Q71Q	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	240	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CACGGGACTTCTGGATGAAGG	0.637													0	0	0	0.001984	0	4	24										T	34059676	C	T	34059676	2	4	99	1	0	0	0	0	0	0	0	1	6799	912	32	1		1	GRM4	6	34059676	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	650689	34059676	137055391	136	30277										
C6orf106	64771	broad.mit.edu	37	chr6	34664291	34664291	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagccgagcagcctctggaaCtcggagatgagcacgtcctt	12	12	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34664291C>T	uc003ojr.2	-	1	335	c.90G>A	c.(88-90)GAG>GAA	p.E30E	C6orf106_uc003ojs.2_Silent_p.E30E	NM_024294	NP_077270	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106 isoform a	30										skin(2)|ovary(1)	3						GCCTCTGGAACTCGGAGATGA	0.647													0	0	0	0.001168	0	5	21										T	34664291	C	T	34664291	2	4	99	1	0	0	0	0	0	0	0	1	2319	564	20	2		2	C6orf106	6	34664291	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	604615	34664291	136450776	137	30278										
ANKS1A	23294	broad.mit.edu	37	chr6	34985689	34985689	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gctgaactcaaactcagccgCagcttgtccaagtctgactc	8	14	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34985689C>T	uc003ojx.3	+	11	2005	c.1863C>T	c.(1861-1863)CGC>CGT	p.R621R	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Silent_p.R161R|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	621						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						AACTCAGCCGCAGCTTGTCCA	0.592													0	0	0	0.00333	0	20	183										T	34985689	C	T	34985689	2	4	99	1	0	0	0	0	0	0	0	1	688	697	25	2		2	ANKS1A	6	34985689	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	321398	34985689	136129378	138	30279										
SCUBE3	222663	broad.mit.edu	37	chr6	35211828	35211828	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	taccaacctgaagcaggacgGaccctatgcttcccttgtgg	10	13	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:35211828G>C	uc003okf.1	+	17	2166	c.2160G>C	c.(2158-2160)CGG>CGC	p.R720R	SCUBE3_uc003okg.1_Silent_p.R719R|SCUBE3_uc003okh.1_Silent_p.R607R	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	720					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AAGCAGGACGGACCCTATGCT	0.567													0	0	0	0.013537	0	10	22										C	35211828	G	C	35211828	2	2	99	1	0	0	0	0	0	0	0	1	13946	1161	41	1		1	SCUBE3	6	35211828	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	226139	35211828	135903239	139	30280										
SCUBE3	222663	broad.mit.edu	37	chr6	35213161	35213161	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accagagatcttcctgccatCtgaggatgagtgtggggacg	14	9	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:35213161C>A	uc003okf.1	+	19	2564	c.2558C>A	c.(2557-2559)TCT>TAT	p.S853Y	SCUBE3_uc003okg.1_Missense_Mutation_p.S852Y|SCUBE3_uc003okh.1_Missense_Mutation_p.S740Y	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	853	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						TTCCTGCCATCTGAGGATGAG	0.567													1	0	3.6726e-16	0.003954	3.94492e-16	19	61										A	35213161	C	A	35213161	3	1	99	1	0	0	0	0	1	0	0	0	13946	913	32	3	2632	3	SCUBE3	6	35213161	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1333	35213161	135901906	140	30281										
LRFN2	57497	broad.mit.edu	37	chr6	40400429	40400429	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caggaagtcctcaaaagcctCatctgcgatgccgcccagct	9	15	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:40400429C>T	uc003oph.1	-	2	889	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	142	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCAAAAGCCTCATCTGCGATG	0.597													0	0	0	0.004878	0	33	34										T	40400429	C	T	40400429	3	4	99	1	0	0	0	0	1	0	0	0	8938	835	29	1	1953	1	LRFN2	6	40400429	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5187268	40400429	130714638	141	30282										
UBR2	23304	broad.mit.edu	37	chr6	42626436	42626436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagaaaagcagagattgccaGactgcgcagagaaaagatca	12	7	1	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:42626436G>A	uc011dur.1	+	29	3116	c.3116G>A	c.(3115-3117)AGA>AAA	p.R1039K	UBR2_uc011dus.1_Missense_Mutation_p.R684K|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1039	Potential.				cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GAGATTGCCAGACTGCGCAGA	0.408													0	0	0	0.00499	0	15	42										A	42626436	G	A	42626436	3	1	99	1	0	0	0	0	1	0	0	0	16899	942	33	1	3376	1	UBR2	6	42626436	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2226007	42626436	128488631	142	30283										
KIAA0240	23506	broad.mit.edu	37	chr6	42796877	42796877	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caactccttgtttgggaactCtagttccagtccagtagcac	8	12	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:42796877C>T	uc003osn.1	+	6	957	c.806C>T	c.(805-807)TCT>TTT	p.S269F	KIAA0240_uc003osm.1_Missense_Mutation_p.S269F|KIAA0240_uc011duw.1_Missense_Mutation_p.S269F|KIAA0240_uc003oso.1_Missense_Mutation_p.S269F|KIAA0240_uc003osp.1_Missense_Mutation_p.S269F	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	269										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			TTTGGGAACTCTAGTTCCAGT	0.453													0	0	0	0.00499	0	14	20										T	42796877	C	T	42796877	3	4	99	1	0	0	0	0	1	0	0	0	8164	913	32	1	820	1	KIAA0240	6	42796877	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	170441	42796877	128318190	143	30284										
XPO5	57510	broad.mit.edu	37	chr6	43492227	43492227	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accccaatgcaaccagcaatGaggcgtttgaattggtcctt	9	11	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:43492227G>C	uc003ovp.2	-	31	3670	c.3459C>G	c.(3457-3459)CTC>CTG	p.L1153L	POLR1C_uc003ovo.1_Intron	NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	1153					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			AACCAGCAATGAGGCGTTTGA	0.473													0	0	0	0.004007	0	11	42										C	43492227	G	C	43492227	2	2	99	1	0	0	0	0	0	0	0	1	17444	1277	45	1		1	XPO5	6	43492227	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	695350	43492227	127622840	144	30285										
SYNCRIP	10492	broad.mit.edu	37	chr6	86349960	86349963	+	Frame_Shift_Del	DEL	TCCT	TCCT	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttaatttttgcctcatctggTcctttactagaatctgctac							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:86349960_86349963delTCCT	uc003pla.2	-	4	892_895	c.351_354delAGGA	c.(349-354)AAAGGAfs	p.K117fs	SYNCRIP_uc003pku.2_Frame_Shift_Del_p.K117fs|SYNCRIP_uc003pkw.2_Frame_Shift_Del_p.K117fs|SYNCRIP_uc003pky.2_Frame_Shift_Del_p.K19fs|SYNCRIP_uc003pkv.2_Frame_Shift_Del_p.K117fs|SYNCRIP_uc003pkx.2_5'UTR|SYNCRIP_uc003pkz.2_Frame_Shift_Del_p.K117fs	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	117_118					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CCTCATCTGGTCCTTTACTAGAAT	0.348																		18	122	---	---								-	86349963	TCCT	-	86349960	7	5	99	1	0	1	0	1	0	0	0	0	15441	1654	58	0	1595	0	SYNCRIP	6	86349960	Frame_Shift_Del	DEL	TCCT	TCGA-G2-A3IE-01A-11D-A20D-08	42857733	86349960	84765107	145	30286										
REV3L	5980	broad.mit.edu	37	chr6	111696839	111696839	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atatagtccaaaggactgctCagtttctaacgttccatctc	6	11	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:111696839C>G	uc003puy.3	-	13	3042	c.2719G>C	c.(2719-2721)GAG>CAG	p.E907Q	REV3L_uc003pux.3_Missense_Mutation_p.E829Q|REV3L_uc003puz.3_Missense_Mutation_p.E829Q	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	907					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGGACTGCTCAGTTTCTAAC	0.378								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.001855	0	4	57										G	111696839	C	G	111696839	3	3	99	1	0	0	0	0	1	0	0	0	13240	835	29	1	6753	1	REV3L	6	111696839	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	25346879	111696839	59418228	146	30287										
REV3L	5980	broad.mit.edu	37	chr6	111696872	111696872	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tccatctccaaagtgacagtCtataaaaccatctgtgggtg	8	10	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:111696872C>G	uc003puy.3	-	13	3009	c.2686G>C	c.(2686-2688)GAC>CAC	p.D896H	REV3L_uc003pux.3_Missense_Mutation_p.D818H|REV3L_uc003puz.3_Missense_Mutation_p.D818H	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	896					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGTGACAGTCTATAAAACCA	0.368								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.003163	0	6	53										G	111696872	C	G	111696872	3	3	99	1	0	0	0	0	1	0	0	0	13240	913	32	1	6786	1	REV3L	6	111696872	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	33	111696872	59418195	147	30288										
RSPH4A	345895	broad.mit.edu	37	chr6	116949506	116949506	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aatccctatccaattgggttCatcatgtacagcatattctc	5	11	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:116949506C>T	uc003pxe.2	+	3	1781	c.1636C>T	c.(1636-1638)CAT>TAT	p.H546Y	RSPH4A_uc010kee.2_Missense_Mutation_p.H546Y	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	546	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						CAATTGGGTTCATCATGTACA	0.403									Kartagener_syndrome				0	0	0	0.01441	0	37	120										T	116949506	C	T	116949506	3	4	99	1	0	0	0	0	1	0	0	0	13706	826	29	1	1646	1	RSPH4A	6	116949506	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5252634	116949506	54165561	148	30289										
TMEM200A	114801	broad.mit.edu	37	chr6	130762134	130762134	+	Frame_Shift_Del	DEL	G	G	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggcatgtacactggtttgatGggagaaacagaagtaaaaca							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:130762134delG	uc003qca.2	+	3	1438	c.567delG	c.(565-567)ATGfs	p.M189fs	TMEM200A_uc010kfh.2_Frame_Shift_Del_p.M189fs|TMEM200A_uc010kfi.2_Frame_Shift_Del_p.M189fs|TMEM200A_uc003qcb.2_Frame_Shift_Del_p.M189fs	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	189	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CTGGTTTGATGGGAGAAACAG	0.448																		9	60	---	---								-	130762134	G	-	130762134	7	5	99	1	0	1	0	1	0	0	0	0	16120	1348	47	0	569	0	TMEM200A	6	130762134	Frame_Shift_Del	DEL	G	TCGA-G2-A3IE-01A-11D-A20D-08	13812628	130762134	40352933	149	30290										
KIAA1244	57221	broad.mit.edu	37	chr6	138483238	138483238	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtcaagatggaagaaatcctGaggaagctgcagaaggaggc	15	6	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138483238G>A	uc003qhu.2	+	1	15	c.15G>A	c.(13-15)CTG>CTA	p.L5L		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	5					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AAGAAATCCTGAGGAAGCTGC	0.647													0	0	0	0.009096	0	3	22										A	138483238	G	A	138483238	2	1	99	1	0	0	0	0	0	0	0	1	8217	1277	45	1		1	KIAA1244	6	138483238	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7721104	138483238	32631829	150	30291										
KIAA1244	57221	broad.mit.edu	37	chr6	138655797	138655797	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcaagggcgacccgttcttCatcctgccctccttccagtc	7	17	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138655797C>A	uc003qhu.2	+	33	5814	c.5814C>A	c.(5812-5814)TTC>TTA	p.F1938L		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1938					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ACCCGTTCTTCATCCTGCCCT	0.572													1	0	5.16669e-11	0.010729	5.51662e-11	7	36										A	138655797	C	A	138655797	3	1	99	1	0	0	0	0	1	0	0	0	8217	825	29	3	5944	3	KIAA1244	6	138655797	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	172559	138655797	32459270	151	30292										
KIAA1244	57221	broad.mit.edu	37	chr6	138655808	138655808	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccgttcttcatcctgccctCcttccagtccgagtcatcca	5	19	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138655808C>T	uc003qhu.2	+	33	5825	c.5825C>T	c.(5824-5826)TCC>TTC	p.S1942F		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1942					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATCCTGCCCTCCTTCCAGTCC	0.577													0	0	0	0.013537	0	7	30										T	138655808	C	T	138655808	3	4	99	1	0	0	0	0	1	0	0	0	8217	855	30	1	5955	1	KIAA1244	6	138655808	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	11	138655808	32459259	152	30293										
SLC22A2	6582	broad.mit.edu	37	chr6	160664743	160664743	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaaccagggcagagtagaaGaaatccaggtagatattgtc	11	7	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:160664743G>A	uc003qtf.2	-	7	1310	c.1140C>T	c.(1138-1140)TTC>TTT	p.F380F	SLC22A2_uc003qte.1_Silent_p.F380F	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	380	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CAGAGTAGAAGAAATCCAGGT	0.527													0	0	0	0.00333	0	19	52										A	160664743	G	A	160664743	2	1	99	1	0	0	0	0	0	0	0	1	14450	933	33	1		1	SLC22A2	6	160664743	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	22008935	160664743	10450324	153	30294										
PDE10A	10846	broad.mit.edu	37	chr6	165806238	165806240	+	In_Frame_Del	DEL	TTC	TTC	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gataaggaacccgccgatagTtcttcttcacagacataata							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:165806238_165806240delTTC	uc003qun.2	-	17	1762_1764	c.1521_1523delGAA	c.(1519-1524)AAGAAC>AAC	p.K507del	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_In_Frame_Del_p.K437del|PDE10A_uc003quo.2_In_Frame_Del_p.K517del	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	507					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCGCCGATAGTTCTTCTTCACAG	0.409																		14	96	---	---								-	165806240	TTC	-	165806238	7	5	99	1	0	1	0	1	0	0	0	0	11630	1725	60	0	844	0	PDE10A	6	165806238	In_Frame_Del	DEL	TTC	TCGA-G2-A3IE-01A-11D-A20D-08	5141495	165806238	5308829	154	30295										
CARD11	84433	broad.mit.edu	37	chr7	2978460	2978460	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagtctggcaggctgcgcttCccggcctgggtgggagggag	20	10	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:2978460C>T	uc003smv.2	-	7	1274	c.870G>A	c.(868-870)GGG>GGA	p.G290G		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	290	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGCTGCGCTTCCCGGCCTGGG	0.632			Mis		DLBCL								0	0	0	0.010504	0	15	50										T	2978460	C	T	2978460	2	4	99	1	0	0	0	0	0	0	0	1	2645	842	30	1		1	CARD11	7	2978460	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		2978460	156160203	155	30296										
COL28A1	340267	broad.mit.edu	37	chr7	7421178	7421178	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatcctgagacacttaccttCtggcctgggaggccatggcc	12	13	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:7421178C>T	uc003src.1	-	28	2319	c.2202G>A	c.(2200-2202)CAG>CAA	p.Q734Q	COL28A1_uc011jxe.1_Silent_p.Q417Q	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	734	Collagen-like 6.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CACTTACCTTCTGGCCTGGGA	0.458													0	0	0	0.01441	0	40	79										T	7421178	C	T	7421178	2	4	99	1	0	0	0	0	0	0	0	1	3686	912	32	1		1	COL28A1	7	7421178	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4442718	7421178	151717485	156	30297										
COL28A1	340267	broad.mit.edu	37	chr7	7516808	7516808	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tactccctcaggaccacgggGaccctggttaggataggaga	13	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:7516808G>A	uc003src.1	-	14	1285	c.1168C>T	c.(1168-1170)CCC>TCC	p.P390S	COL28A1_uc011jxe.1_Missense_Mutation_p.P73S|COL28A1_uc003srd.2_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	390	Collagen-like 3.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGACCACGGGGACCCTGGTTa	0.308													0	0	0	0.006214	0	8	28										A	7516808	G	A	7516808	3	1	99	1	0	0	0	0	1	0	0	0	3686	1174	41	1	2297	1	COL28A1	7	7516808	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	95630	7516808	151621855	157	30298										
SNX13	23161	broad.mit.edu	37	chr7	17890577	17890577	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggcctcatagttgcagttaGaatcacggatctgaaaacaa	9	8	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:17890577G>C	uc003stw.1	-	10	1061	c.848C>G	c.(847-849)TCT>TGT	p.S283C	SNX13_uc003stv.2_Missense_Mutation_p.S283C|SNX13_uc010kuc.2_Missense_Mutation_p.S80C			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	283	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					GTTGCAGTTAGAATCACGGAT	0.318													0	0	0	0.000602	0	3	12										C	17890577	G	C	17890577	3	2	99	1	0	0	0	0	1	0	0	0	14884	942	33	1	2093	1	SNX13	7	17890577	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	10373769	17890577	141248086	158	30299										
BBS9	27241	broad.mit.edu	37	chr7	33407465	33407465	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaattactgttcttgcttccAaaacttctcgtaagtaaaac	5	9	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:33407465A>C	uc003tdn.1	+	17	2293	c.1780A>C	c.(1780-1782)AAA>CAA	p.K594Q	BBS9_uc003tdo.1_Missense_Mutation_p.K559Q|BBS9_uc003tdp.1_Missense_Mutation_p.K589Q|BBS9_uc003tdq.1_Missense_Mutation_p.K554Q|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.K118Q|BBS9_uc003tds.1_Missense_Mutation_p.K17Q|BBS9_uc011kao.1_Missense_Mutation_p.K472Q	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	594					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TCTTGCTTCCAAAACTTCTCG	0.363									Bardet-Biedl_syndrome				0	0	0	0.013537	0	12	49										C	33407465	A	C	33407465	3	2	99	1	0	0	0	0	1	0	0	0	1342	131	5	5	1842	5	BBS9	7	33407465	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	15516888	33407465	125731198	159	30300										
ABCA13	154664	broad.mit.edu	37	chr7	48318544	48318544	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaatagatcatttcacatttGaaaagataaatgatttgttg	6	3	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:48318544G>T	uc003toq.2	+	18	7778	c.7753G>T	c.(7753-7755)GAA>TAA	p.E2585*	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2585					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTTCACATTTGAAAAGATAAA	0.308													1	0	8.00594e-06	0.007413	8.25228e-06	17	65										T	48318544	G	T	48318544	4	4	99	1	0	0	0	0	0	1	0	0	31	1291	45	3	7652	3	ABCA13	7	48318544	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	14911079	48318544	110820119	160	30301										
FIGNL1	63979	broad.mit.edu	37	chr7	50513083	50513083	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtaagctatgggtcgaacttGatccggtgttatggtagcaa	13	6	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:50513083G>C	uc003tpc.2	-	4	2280	c.1903C>G	c.(1903-1905)CAA>GAA	p.Q635E	FIGNL1_uc003tpb.2_Missense_Mutation_p.Q524E|FIGNL1_uc003tpd.2_Missense_Mutation_p.Q635E|FIGNL1_uc003tpe.2_Missense_Mutation_p.Q635E|FIGNL1_uc010kyy.2_Missense_Mutation_p.Q635E	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	635					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GGTCGAACTTGATCCGGTGTT	0.418													0	0	0	0.00499	0	16	39										C	50513083	G	C	50513083	3	2	99	1	0	0	0	0	1	0	0	0	5892	1299	45	1	125	1	FIGNL1	7	50513083	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2194539	50513083	108625580	161	30302										
WBSCR17	64409	broad.mit.edu	37	chr7	71130439	71130439	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggaggtccttccttgctcacGggtggcccacattgagcgga	14	12	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:71130439G>A	uc003tvy.2	+	7	1124	c.1124G>A	c.(1123-1125)CGG>CAG	p.R375Q	WBSCR17_uc003tvz.2_Missense_Mutation_p.R74Q	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	375	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCTTGCTCACGGGTGGCCCAC	0.517													0	0	0	0.00308	0	5	75										A	71130439	G	A	71130439	3	1	99	1	0	0	0	0	1	0	0	0	17261	1116	39	2	1150	2	WBSCR17	7	71130439	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	20617356	71130439	88008224	162	30303										
SPDYE5	442590	broad.mit.edu	37	chr7	75130895	75130895	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gttaggccgttccatgaaccCgagggccaggaagaaccgct	13	12	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:75130895C>T	uc011kfy.1	+	6	906	c.770C>T	c.(769-771)CCG>CTG	p.P257L		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	257	Arg-rich.										0						TCCATGAACCCGAGGGCCAGG	0.592													0	0	0	0.010729	0	6	291										T	75130895	C	T	75130895	3	4	99	1	0	0	0	0	1	0	0	0	15031	652	23	2	792	2	SPDYE5	7	75130895	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4000456	75130895	84007768	163	30304										
DMTF1	9988	broad.mit.edu	37	chr7	86794344	86794344	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caggacacagaagggaatctCattcttcactgccctcagaa	8	12	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:86794344C>A	uc003uih.2	+	3	413	c.87C>A	c.(85-87)CTC>CTA	p.L29L	DMTF1_uc003uii.2_5'UTR|DMTF1_uc003uij.2_5'UTR|DMTF1_uc011khb.1_Intron|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Silent_p.L29L|DMTF1_uc003uim.1_Silent_p.L29L|DMTF1_uc003uin.2_5'UTR	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	29	Interaction with CCND2 (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					AAGGGAATCTCATTCTTCACT	0.418													1	0	5.35267e-07	0.007413	5.59265e-07	15	49										A	86794344	C	A	86794344	2	1	99	1	0	0	0	0	0	0	0	1	4592	813	29	3		3	DMTF1	7	86794344	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	11663449	86794344	72344319	164	30305										
ABCB1	5243	broad.mit.edu	37	chr7	87150136	87150136	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcatacatatgttcaaacttCtgctcctgagtcaaagaaac	6	10	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87150136C>A	uc003uiz.1	-	23	3160	c.2742G>T	c.(2740-2742)CAG>CAT	p.Q914H	ABCB1_uc011khc.1_Missense_Mutation_p.Q850H	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	914	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTTCAAACTTCTGCTCCTGAG	0.408													1	0	6.4771e-29	0.010771	7.11419e-29	36	64										A	87150136	C	A	87150136	3	1	99	1	0	0	0	0	1	0	0	0	40	912	32	3	1128	3	ABCB1	7	87150136	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	355792	87150136	71988527	165	30306										
ABCB1	5243	broad.mit.edu	37	chr7	87174162	87174162	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agcctctttggtactaagctTtctgtcttgggcttgtgatc	10	9	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87174162T>C	uc003uiz.1	-	17	2459	c.2041A>G	c.(2041-2043)AAG>GAG	p.K681E	ABCB1_uc011khc.1_Missense_Mutation_p.K617E	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	681	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTACTAAGCTTTCTGTCTTGG	0.433													0	0	0	0.001855	0	10	100										C	87174162	T	C	87174162	3	2	99	1	0	0	0	0	1	0	0	0	40	1850	64	5	1853	5	ABCB1	7	87174162	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	24026	87174162	71964501	166	30307										
ABCB1	5243	broad.mit.edu	37	chr7	87180046	87180046	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccaactcagacttacattatCaattatcttgaagatttcat	3	9	4	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87180046C>G	uc003uiz.1	-	11	1526	c.1108G>C	c.(1108-1110)GAT>CAT	p.D370H	ABCB1_uc011khc.1_Missense_Mutation_p.D306H	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	370	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTTACATTATCAATTATCTTG	0.373													0	0	0	0.007413	0	13	37										G	87180046	C	G	87180046	3	3	99	1	0	0	0	0	1	0	0	0	40	826	29	1	2810	1	ABCB1	7	87180046	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5884	87180046	71958617	167	30308										
C7orf63	79846	broad.mit.edu	37	chr7	89912334	89912334	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagatgagactgtaaacaaaGatctttgtgaaaagggaaca	10	4	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:89912334G>C	uc010lep.2	+	13	1752	c.1501G>C	c.(1501-1503)GAT>CAT	p.D501H	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.D176H|C7orf63_uc011khj.1_Missense_Mutation_p.D483H|C7orf63_uc011khk.1_Missense_Mutation_p.D63H	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	501							binding			ovary(1)	1						TGTAAACAAAGATCTTTGTGA	0.383													0	0	0	0.012319	0	17	28										C	89912334	G	C	89912334	3	2	99	1	0	0	0	0	1	0	0	0	2409	942	33	1	1551	1	C7orf63	7	89912334	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2732288	89912334	69226329	168	30309										
DLX6	1750	broad.mit.edu	37	chr7	96635545	96635547	+	In_Frame_Del	DEL	CAC	CAC	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggcggcagcggccggctcgCaccaccaccaccaccaccag							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:96635545_96635547delCAC	uc003uom.2	+	2	172_174	c.172_174delCAC	c.(172-174)CACdel	p.H63del	DLX6AS_uc003uok.2_5'Flank|DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	Error:Variant_position_missing_in_P56179_after_alignment					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GGCCGGCTCGcaccaccaccacc	0.571																		3	6	---	---								-	96635547	CAC	-	96635545	7	5	99	1	0	1	0	1	0	0	0	0	4575	710	25	0	258	0	DLX6	7	96635545	In_Frame_Del	DEL	CAC	TCGA-G2-A3IE-01A-11D-A20D-08	6723211	96635545	62503118	169	30310										
ZNF394	84124	broad.mit.edu	37	chr7	99097298	99097298	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgagcgctcgctgcagagccCgcaccacggccaccgcctcc	11	21	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:99097298C>T	uc003uqs.2	-	1	580	c.419G>A	c.(418-420)CGG>CAG	p.R140Q	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.R140Q	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	140	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGCAGAGCCCGCACCACGGC	0.632													0	0	0	0.01441	0	38	99										T	99097298	C	T	99097298	3	4	99	1	0	0	0	0	1	0	0	0	17877	652	23	2	1278	2	ZNF394	7	99097298	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2461753	99097298	60041365	170	30311										
MUC17	140453	broad.mit.edu	37	chr7	100678824	100678824	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cacttctactgaagcctgttCatctcctacaacttctgaag	5	13	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100678824C>T	uc003uxp.1	+	3	4180	c.4127C>T	c.(4126-4128)TCA>TTA	p.S1376L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1376	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCTGTTCATCTCCTACA	0.493													0	0	0	0.01441	0	128	301										T	100678824	C	T	100678824	3	4	99	1	0	0	0	0	1	0	0	0	9974	838	29	1	4137	1	MUC17	7	100678824	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1581526	100678824	58459839	171	30312										
RELN	5649	broad.mit.edu	37	chr7	103155835	103155835	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catgtcttggctgccaccagCggaagcgagtggcaatctct	12	12	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:103155835C>T	uc003vca.2	-	50	8076	c.7916G>A	c.(7915-7917)CGC>CAC	p.R2639H	RELN_uc010liz.2_Missense_Mutation_p.R2639H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2639					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCCACCAGCGGAAGCGAGT	0.512													0	0	0	0.004007	0	13	42										T	103155835	C	T	103155835	3	4	99	1	0	0	0	0	1	0	0	0	13220	768	27	2	2530	2	RELN	7	103155835	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2477011	103155835	55982828	172	30313										
SYPL1	6856	broad.mit.edu	37	chr7	105752610	105752610	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcgaggaccttgatgaagccGagtggctccttgagcgggtt	15	9	0	3	rs147008337	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:105752610G>C	uc003vdp.2	-	2	181	c.99C>G	c.(97-99)CTC>CTG	p.L33L	SYPL1_uc003vdo.2_Silent_p.L15L	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	33	Cytoplasmic (Potential).|MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						TGATGAAGCCGAGTGGCTCCT	0.498													0	0	0	0.00245	0	12	21										C	105752610	G	C	105752610	2	2	99	1	0	0	0	0	0	0	0	1	15459	1045	37	1		1	SYPL1	7	105752610	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2596775	105752610	53386053	173	30314										
SYPL1	6856	broad.mit.edu	37	chr7	105752622	105752622	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atgaagccgagtggctccttGagcgggttgaggttgatctg	16	7	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:105752622G>C	uc003vdp.2	-	2	169	c.87C>G	c.(85-87)CTC>CTG	p.L29L	SYPL1_uc003vdo.2_Silent_p.L11L	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	29	Cytoplasmic (Potential).|MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						GTGGCTCCTTGAGCGGGTTGA	0.493													0	0	0	0.007413	0	14	22										C	105752622	G	C	105752622	2	2	99	1	0	0	0	0	0	0	0	1	15459	1277	45	1		1	SYPL1	7	105752622	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	12	105752622	53386041	174	30315										
SLC13A1	6561	broad.mit.edu	37	chr7	122769443	122769443	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtgtttgtcttaccttattGgcccaagcttttggtattct	8	8	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:122769443G>A	uc003vkm.2	-	9	1050	c.1025C>T	c.(1024-1026)CCA>CTA	p.P342L	SLC13A1_uc010lks.2_Missense_Mutation_p.P218L	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	342						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TTACCTTATTGGCCCAAGCTT	0.294													0	0	0	0.00333	0	21	27										A	122769443	G	A	122769443	3	1	99	1	0	0	0	0	1	0	0	0	14391	1348	47	2	790	2	SLC13A1	7	122769443	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	17016821	122769443	36369220	175	30316										
TBXAS1	6916	broad.mit.edu	37	chr7	139661804	139661804	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gactttgacatcgtcagagaCgttttctcctctactgggtg	10	10	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:139661804C>T	uc011kqv.1	+	10	1211	c.1047C>T	c.(1045-1047)GAC>GAT	p.D349D	TBXAS1_uc003vvh.2_Silent_p.D303D|TBXAS1_uc010lne.2_Silent_p.D235D|TBXAS1_uc011kqu.1_Silent_p.D254D|TBXAS1_uc003vvi.2_Silent_p.D303D|TBXAS1_uc003vvj.2_Silent_p.D303D|TBXAS1_uc011kqw.1_Silent_p.D283D	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	302	Lumenal (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					TCGTCAGAGACGTTTTCTCCT	0.562													0	0	0	0.007291	0	23	29										T	139661804	C	T	139661804	2	4	99	1	0	0	0	0	0	0	0	1	15661	535	19	2		2	TBXAS1	7	139661804	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	16892361	139661804	19476859	176	30317										
JHDM1D	80853	broad.mit.edu	37	chr7	139799789	139799789	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggatggttggagatgtttgTtgaattttccattcagttta	11	3	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:139799789T>C	uc003vvm.2	-	13	1677	c.1673A>G	c.(1672-1674)AAC>AGC	p.N558S	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	558					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GAGATGTTTGTTGAATTTTCC	0.398													0	0	0	0.01441	0	44	83										C	139799789	T	C	139799789	3	2	99	1	0	0	0	0	1	0	0	0	7948	1725	60	5	1184	5	JHDM1D	7	139799789	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	137985	139799789	19338874	177	30318										
TRPV5	56302	broad.mit.edu	37	chr7	142609893	142609893	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccccagactggttgggtcctCtgtctggaaaatgatataga	11	9	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:142609893C>G	uc003wby.1	-	13	1807	c.1543G>C	c.(1543-1545)GAG>CAG	p.E515Q		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	515					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GTTGGGTCCTCTGTCTGGAAA	0.468													0	0	0	0.00874	0	35	71										G	142609893	C	G	142609893	3	3	99	1	0	0	0	0	1	0	0	0	16596	922	32	1	658	1	TRPV5	7	142609893	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2810104	142609893	16528770	178	30319										
ZNF282	8427	broad.mit.edu	37	chr7	148921496	148921496	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgtaaggagcacctgcagaaCcaccagcggctgcacacggg	13	14	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:148921496C>G	uc003wfm.2	+	8	1878	c.1773C>G	c.(1771-1773)AAC>AAG	p.N591K	ZNF282_uc011kun.1_3'UTR|ZNF282_uc003wfo.2_3'UTR	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	591	C2H2-type 3.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		ACCTGCAGAACCACCAGCGGC	0.632													0	0	0	0.001855	0	12	32										G	148921496	C	G	148921496	3	3	99	1	0	0	0	0	1	0	0	0	17816	506	18	4	1803	4	ZNF282	7	148921496	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	6311603	148921496	10217167	179	30320										
ZNF282	8427	broad.mit.edu	37	chr7	148921658	148921658	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttccgctacaaggagtcgctCaaggaccacctgcgcgtgca	11	14	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:148921658C>G	uc003wfm.2	+	8	2040	c.1935C>G	c.(1933-1935)CTC>CTG	p.L645L	ZNF282_uc011kun.1_3'UTR|ZNF282_uc003wfo.2_3'UTR	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	645	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		AGGAGTCGCTCAAGGACCACC	0.597													0	0	0	0.001168	0	6	7										G	148921658	C	G	148921658	2	3	99	1	0	0	0	0	0	0	0	1	17816	813	29	1		1	ZNF282	7	148921658	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	162	148921658	10217005	180	30321										
SSPO	23145	broad.mit.edu	37	chr7	149489754	149489754	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccagtggtccttccggagctCcaacaacccccgcccctccg	8	21	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:149489754C>G	uc010lpk.2	+	39	5810	c.5810C>G	c.(5809-5811)TCC>TGC	p.S1937C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1937	TSP type-1 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTCCGGAGCTCCAACAACCCC	0.697													0	0	0	0.006122	0	14	26										G	149489754	C	G	149489754	3	3	99	1	0	0	0	0	1	0	0	0	15188	855	30	1	5956	1	SSPO	7	149489754	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	568096	149489754	9648909	181	30322										
REPIN1	29803	broad.mit.edu	37	chr7	150068792	150068792	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccaaatgcgagagacgcttCtggcgacgaaagcagcttcg	12	12	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:150068792C>T	uc010lpq.1	+	4	951	c.462C>T	c.(460-462)TTC>TTT	p.F154F	REPIN1_uc003whd.2_Silent_p.F143F|REPIN1_uc010lpr.1_Silent_p.F211F|REPIN1_uc003whc.2_Silent_p.F154F|REPIN1_uc003whe.2_Silent_p.F154F	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	154	C2H2-type 4.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGAGACGCTTCTGGCGACGAA	0.662													0	0	0	0.006214	0	6	6										T	150068792	C	T	150068792	2	4	99	1	0	0	0	0	0	0	0	1	13227	912	32	1		1	REPIN1	7	150068792	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	579038	150068792	9069871	182	30323										
MLL3	58508	broad.mit.edu	37	chr7	151851456	151851456	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatacctgctcacttctaccCcaaccacactctcaggagag	6	16	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:151851456C>G	uc003wla.2	-	47	12254	c.12035G>C	c.(12034-12036)GGG>GCG	p.G4012A	MLL3_uc003wkz.2_Missense_Mutation_p.G3130A|MLL3_uc003wkx.2_Missense_Mutation_p.G170A|MLL3_uc003wky.2_Missense_Mutation_p.G1576A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4012					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CACTTCTACCCCAACCACACT	0.498			N		medulloblastoma								0	0	0	0.01441	0	37	121										G	151851456	C	G	151851456	3	3	99	1	0	0	0	0	1	0	0	0	9622	623	22	4	2752	4	MLL3	7	151851456	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1782664	151851456	7287207	183	30324										
FGF17	8822	broad.mit.edu	37	chr8	21903643	21903643	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agggggagaatcacccgtctCctaattttaaccagtacgtg	10	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:21903643C>G	uc003xag.2	+	3	103	c.91C>G	c.(91-93)CCT>GCT	p.P31A	FGF17_uc003xah.2_Intron|FGF17_uc003xai.2_Missense_Mutation_p.P54A	NM_003867	NP_003858	O60258	FGF17_HUMAN	fibroblast growth factor 17 precursor	31					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		TCACCCGTCTCCTAATTTTAA	0.557													0	0	0	0.005524	0	30	22										G	21903643	C	G	21903643	3	3	99	1	0	0	0	0	1	0	0	0	5845	855	30	1	101	1	FGF17	8	21903643	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		21903643	124460379	184	30325										
PNMA2	10687	broad.mit.edu	37	chr8	26365475	26365475	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctagccgtaacacataggctGagaccttctctccttcctcc	6	16	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:26365475G>A	uc003xez.2	-	3	1567	c.797C>T	c.(796-798)TCA>TTA	p.S266L		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	266					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		cacataggctgagaccttctc	0													0	0	0	0.003163	0	13	18										A	26365475	G	A	26365475	3	1	99	1	0	0	0	0	1	0	0	0	12154	1294	45	1	301	1	PNMA2	8	26365475	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4461832	26365475	119998547	185	30326										
NRG1	3084	broad.mit.edu	37	chr8	32621582	32621582	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atgaggagtatgaaacgaccCaagagtacgagccagcccaa	11	10	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:32621582C>A	uc003xiv.2	+	12	2102	c.1585C>A	c.(1585-1587)CAA>AAA	p.Q529K	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Missense_Mutation_p.Q534K|NRG1_uc003xiw.2_Missense_Mutation_p.Q526K|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Missense_Mutation_p.Q271K|NRG1_uc010lvs.2_Missense_Mutation_p.Q271K|NRG1_uc010lvp.2_Missense_Mutation_p.Q483K|NRG1_uc010lvq.2_Missense_Mutation_p.Q466K|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Missense_Mutation_p.Q372K|NRG1_uc003xja.2_Missense_Mutation_p.Q340K	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	529	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGAAACGACCCAAGAGTACGA	0.542													1	0	3.07112e-06	0.010729	3.17784e-06	11	21										A	32621582	C	A	32621582	3	1	99	1	0	0	0	0	1	0	0	0	10647	595	21	4	3356	4	NRG1	8	32621582	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	6256107	32621582	113742440	186	30327										
IKBKB	3551	broad.mit.edu	37	chr8	42176072	42176072	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgtgtctctgtctccagttCaagagcccaagaggaatctc	9	11	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:42176072C>G	uc003xow.1	+	13	1420	c.1243C>G	c.(1243-1245)CAA>GAA	p.Q415E	IKBKB_uc010lxh.1_Missense_Mutation_p.Q310E|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.Q192E|IKBKB_uc003xox.1_Missense_Mutation_p.Q136E|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.Q413E|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.Q356E	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	415					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GTCTCCAGTTCAAGAGCCCAA	0.498													0	0	0	0.01441	0	47	92										G	42176072	C	G	42176072	3	3	99	1	0	0	0	0	1	0	0	0	7611	827	29	1	1289	1	IKBKB	8	42176072	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9554490	42176072	104187950	187	30328										
CSPP1	79848	broad.mit.edu	37	chr8	68044264	68044264	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgatttttgaagataaaccGaaaccttccaaacagtcact	5	9	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:68044264G>A	uc003xxi.2	+	16	1897	c.1866G>A	c.(1864-1866)CCG>CCA	p.P622P	CSPP1_uc003xxg.1_Silent_p.P614P|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Silent_p.P587P|CSPP1_uc003xxk.2_Silent_p.P293P	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	622						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGATAAACCGAAACCTTCCA	0.353													0	0	0	0.004289	0	28	69										A	68044264	G	A	68044264	2	1	99	1	0	0	0	0	0	0	0	1	3962	1045	37	1		1	CSPP1	8	68044264	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	25868192	68044264	78319758	188	30329										
TPD52	7163	broad.mit.edu	37	chr8	80992661	80992661	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaacggggactggtagtcctCatataagtccatctctctac	8	11	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:80992661C>A	uc003ybr.1	-	1	350	c.28G>T	c.(28-30)GAG>TAG	p.E10*	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_Intron|TPD52_uc003ybs.1_Intron|TPD52_uc003ybt.1_Intron	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	10					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TGGTAGTCCTCATATAAGTCC	0.463													1	0	1.55469e-16	0.00333	1.68007e-16	19	38										A	80992661	C	A	80992661	4	1	99	1	0	0	0	0	0	1	0	0	16394	835	29	3	747	3	TPD52	8	80992661	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	12948397	80992661	65371361	189	30330										
C8orf37	157657	broad.mit.edu	37	chr8	96281381	96281381	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggtgtgcaaaacttggactCgacttcatccaagagctcgt	10	10	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:96281381C>G	uc003yho.1	-	1	57	c.37G>C	c.(37-39)GAG>CAG	p.E13Q		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	13											0	Breast(36;3.41e-05)					AACTTGGACTCGACTTCATCC	0.592											OREG0018873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	82	247										G	96281381	C	G	96281381	3	3	99	1	0	0	0	0	1	0	0	0	2423	893	31	1	610	1	C8orf37	8	96281381	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	15288720	96281381	50082641	190	30331										
MTERFD1	51001	broad.mit.edu	37	chr8	97269316	97269316	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctctgaaattggctgcattgGagacaatggaggcaattcat	11	7	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:97269316G>C	uc003yhs.1	-	3	439	c.361C>G	c.(361-363)CCA>GCA	p.P121A	MTERFD1_uc003yhr.1_5'UTR|MTERFD1_uc010mbd.1_Missense_Mutation_p.P121A	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	121					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					GGCTGCATTGGAGACAATGGA	0.418													0	0	0	0.004289	0	27	134										C	97269316	G	C	97269316	3	2	99	1	0	0	0	0	1	0	0	0	9919	1174	41	1	916	1	MTERFD1	8	97269316	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	987935	97269316	49094706	191	30332										
MRPL13	28998	broad.mit.edu	37	chr8	121426333	121426333	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctcctctactaaattcttaaGaatatcttctggaatatact	3	9	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:121426333G>C	uc003ypa.2	-	6	725	c.412C>G	c.(412-414)CTT>GTT	p.L138V	MRPL13_uc010mdf.2_RNA	NM_014078	NP_054797	Q9BYD1	RM13_HUMAN	mitochondrial ribosomal protein L13	138					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			central_nervous_system(1)	1	Lung NSC(37;1.69e-07)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AAATTCTTAAGAATATCTTCT	0.294													0	0	0	0.000602	0	4	15										C	121426333	G	C	121426333	3	2	99	1	0	0	0	0	1	0	0	0	9778	942	33	1	132	1	MRPL13	8	121426333	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	24157017	121426333	24937689	192	30333										
SCRIB	23513	broad.mit.edu	37	chr8	144885702	144885702	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caacagccgcaaacccacacGcagccgaccgtcgcgcccgg	10	20	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:144885702G>A	uc003yzp.1	-	24	3461	c.3454C>T	c.(3454-3456)CGT>TGT	p.R1152C	SCRIB_uc003yzn.1_5'UTR|SCRIB_uc003yzo.1_Missense_Mutation_p.R1152C	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1152	PDZ 4.|Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AAACCCACACGCAGCCGACCG	0.721													0	0	0	0.007291	0	21	34										A	144885702	G	A	144885702	3	1	99	1	0	0	0	0	1	0	0	0	13937	1087	38	2	1569	2	SCRIB	8	144885702	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	23459369	144885702	1478320	193	30334										
MFSD3	113655	broad.mit.edu	37	chr8	145736235	145736235	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggaggcctggtcaccacagtCaccttcactgggatgatgcg	13	12	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:145736235C>G	uc003zdi.1	+	4	1179	c.1014C>G	c.(1012-1014)GTC>GTG	p.V338V		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	338	Leu-rich.|Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCACCACAGTCACCTTCACTG	0.642													0	0	0	0.004007	0	14	37										G	145736235	C	G	145736235	2	3	99	1	0	0	0	0	0	0	0	1	9532	813	29	1		1	MFSD3	8	145736235	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	850533	145736235	627787	194	30335										
ZNF251	90987	broad.mit.edu	37	chr8	145979132	145979132	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agattcaggacccaaagttcCttcccctgctccagctggga	9	14	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:145979132C>T	uc003zdv.3	-	4	469	c.213G>A	c.(211-213)AAG>AAA	p.K71K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CCCAAAGTTCCTTCCCCTGCT	0.552													0	0	0	0.008291	0	7	13										T	145979132	C	T	145979132	2	4	99	1	0	0	0	0	0	0	0	1	17793	680	24	2		2	ZNF251	8	145979132	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	242897	145979132	384890	195	30336										
FOXD4	2298	broad.mit.edu	37	chr9	117910	117910	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctcgggccgccgccgccctcGatgtgctctcggggaagcgc	15	17	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:117910G>A	uc003zfz.2	-	1	508	c.210C>T	c.(208-210)ATC>ATT	p.I70I		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	70					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CGCCGCCCTCGATGTGCTCTC	0.716													0	0	0	0.014323	0	15	135										A	117910	G	A	117910	2	1	99	1	0	0	0	0	0	0	0	1	5999	1048	37	1		1	FOXD4	9	117910	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		117910	141095521	196	30337										
KANK1	23189	broad.mit.edu	37	chr9	713382	713383	+	Frame_Shift_Del	DEL	TA	TA	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctcatcagcaccctgtcgtcTatcaactctgtcatgaaatc					rs144413163		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:713382_713383delTA	uc003zgl.1	+	7	3265_3266	c.2616_2617delTA	c.(2614-2619)TCTATCfs	p.S872fs	KANK1_uc003zgm.2_Frame_Shift_Del_p.S872fs|KANK1_uc003zgn.1_Frame_Shift_Del_p.S872fs|KANK1_uc003zgo.1_Frame_Shift_Del_p.S872fs|KANK1_uc003zgp.1_Frame_Shift_Del_p.S872fs|KANK1_uc003zgq.2_Frame_Shift_Del_p.S714fs|KANK1_uc003zgr.1_Frame_Shift_Del_p.S714fs|KANK1_uc003zgs.1_Frame_Shift_Del_p.S714fs	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	872_873					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CCCTGTCGTCTATCAACTCTGT	0.515																		29	58	---	---								-	713383	TA	-	713382	7	5	99	1	0	1	0	1	0	0	0	0	7976	1509	53	0	2622	0	KANK1	9	713382	Frame_Shift_Del	DEL	TA	TCGA-G2-A3IE-01A-11D-A20D-08	595472	713382	140500049	197	30338										
SMARCA2	6595	broad.mit.edu	37	chr9	2110327	2110327	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggatcccagtatttcattttCttgctgagcacaagagctgg	10	9	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:2110327C>G	uc003zhc.2	+	24	3465	c.3366C>G	c.(3364-3366)TTC>TTG	p.F1122L	SMARCA2_uc003zhd.2_Missense_Mutation_p.F1122L|SMARCA2_uc010mha.2_Missense_Mutation_p.F1055L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1122	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATTTCATTTTCTTGCTGAGCA	0.463													0	0	0	0.004878	0	30	41										G	2110327	C	G	2110327	3	3	99	1	0	0	0	0	1	0	0	0	14769	912	32	1	3456	1	SMARCA2	9	2110327	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1396945	2110327	139103104	198	30339										
FAM154A	158297	broad.mit.edu	37	chr9	18928110	18928110	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaatcatctacagaaagatgGctgctctgctgagagcctgc	11	10	3	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:18928110G>A	uc003zni.1	-	4	1643	c.1365C>T	c.(1363-1365)AGC>AGT	p.S455S	FAM154A_uc010mip.1_Silent_p.S263S	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	455										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		CAGAAAGATGGCTGCTCTGCT	0.433													0	0	0	0.01441	0	51	44										A	18928110	G	A	18928110	2	1	99	1	0	0	0	0	0	0	0	1	5463	1194	42	2		2	FAM154A	9	18928110	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	16817783	18928110	122285321	199	30340										
DDX58	23586	broad.mit.edu	37	chr9	32487490	32487493	+	Frame_Shift_Del	DEL	CTTG	CTTG	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cttctggggcttataaacaaCttgctccagttcctccagat							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:32487490_32487493delCTTG	uc003zra.2	-	9	1509_1512	c.1351_1354delCAAG	c.(1351-1356)CAAGTTfs	p.Q451fs	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Frame_Shift_Del_p.Q406fs|DDX58_uc011lnr.1_Frame_Shift_Del_p.Q248fs|DDX58_uc010mji.2_Frame_Shift_Del_p.Q380fs	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	451_452					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TTATAAACAACTTGCTCCAGTTCC	0.422																		8	91	---	---								-	32487493	CTTG	-	32487490	7	5	99	1	0	1	0	1	0	0	0	0	4375	565	20	0	1463	0	DDX58	9	32487490	Frame_Shift_Del	DEL	CTTG	TCGA-G2-A3IE-01A-11D-A20D-08	13559380	32487490	108725941	200	30341										
CNTNAP3	79937	broad.mit.edu	37	chr9	39178358	39178358	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaaataaaccacctcagattCtaggaaagaagatattagaa	6	6	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:39178358C>G	uc004abi.2	-	5	778	c.539_splice	c.e5-1	p.K180_splice	CNTNAP3_uc004abj.2_Splice_Site_p.K180_splice|CNTNAP3_uc011lqr.1_Splice_Site|CNTNAP3_uc004abk.1_Splice_Site_p.K180_splice|CNTNAP3_uc011lqs.1_Splice_Site_p.K180_splice|CNTNAP3_uc004abl.1_Splice_Site_p.K92_splice	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor						cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACCTCAGATTCTAGGAAAGAA	0.313													0	0	0	0.010771	0	32	34										G	39178358	C	G	39178358	5	3	99	1	0	0	0	0	0	0	1	0	3648	927	32	1	3408	1	CNTNAP3	9	39178358	Splice_Site	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	6690868	39178358	102035073	201	30342										
GDA	9615	broad.mit.edu	37	chr9	74838100	74838100	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctgctctgagactttgatggGtgaactgggcaacattgcta	12	8	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:74838100G>A	uc004aiq.2	+	7	854	c.671G>A	c.(670-672)GGT>GAT	p.G224D	GDA_uc011lse.1_Missense_Mutation_p.G150D|GDA_uc011lsf.1_Missense_Mutation_p.G150D|GDA_uc004air.2_Missense_Mutation_p.G224D|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Intron|GDA_uc004ait.1_Missense_Mutation_p.G150D	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	224					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ACTTTGATGGGTGAACTGGGC	0.408													0	0	0	0.013537	0	8	73										A	74838100	G	A	74838100	3	1	99	1	0	0	0	0	1	0	0	0	6306	1261	44	2	697	2	GDA	9	74838100	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	35659742	74838100	66375331	202	30343										
PRUNE2	158471	broad.mit.edu	37	chr9	79324197	79324197	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccgtggagttaccatcttttGactcaaaaccttcctcttta	5	12	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:79324197G>C	uc010mpk.2	-	8	3117	c.2993C>G	c.(2992-2994)TCA>TGA	p.S998*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	998					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ACCATCTTTTGACTCAAAACC	0.453													0	0	0	0.00245	0	14	13										C	79324197	G	C	79324197	4	2	99	1	0	0	0	0	0	1	0	0	12641	1294	45	1	6321	1	PRUNE2	9	79324197	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4486097	79324197	61889234	203	30344										
SLC28A3	64078	broad.mit.edu	37	chr9	86955491	86955491	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaggaaagctctgctcacctGgaagcccacgttgctgtagc	12	12	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:86955491G>A	uc010mpz.2	-	1	183	c.58C>T	c.(58-60)CAG>TAG	p.Q20*	SLC28A3_uc011lsy.1_5'UTR|SLC28A3_uc004anu.1_Nonsense_Mutation_p.Q20*|SLC28A3_uc010mqb.2_5'UTR	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	20	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						CTGCTCACCTGGAAGCCCACG	0.532													0	0	0	0.003954	0	20	31										A	86955491	G	A	86955491	4	1	99	1	0	0	0	0	0	1	0	0	14533	1357	47	2	2089	2	SLC28A3	9	86955491	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7631294	86955491	54257940	204	30345										
FAM120A	23196	broad.mit.edu	37	chr9	96259828	96259828	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctgactatgtacgcaacattCaggacacctctgacttggat	8	11	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:96259828C>T	uc004atw.2	+	4	905	c.880C>T	c.(880-882)CAG>TAG	p.Q294*	FAM120A_uc004atv.2_Nonsense_Mutation_p.Q294*|FAM120A_uc004atx.2_Nonsense_Mutation_p.Q76*|FAM120A_uc004aty.2_Nonsense_Mutation_p.Q76*	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	294						cytoplasm|plasma membrane	RNA binding				0						ACGCAACATTCAGGACACCTC	0.433													0	0	0	0.008361	0	29	17										T	96259828	C	T	96259828	4	4	99	1	0	0	0	0	0	1	0	0	5415	827	29	1	894	1	FAM120A	9	96259828	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9304337	96259828	44953603	205	30346										
NIPSNAP3A	25934	broad.mit.edu	37	chr9	107521388	107521388	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catgttctttggtggaatgaGagtgcagatagtcgtgcagc	14	6	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:107521388G>C	uc004bch.1	+	5	708	c.603G>C	c.(601-603)GAG>GAC	p.E201D	NIPSNAP3A_uc011lvt.1_Missense_Mutation_p.E201D|NIPSNAP3A_uc011lvu.1_Intron	NM_015469	NP_056284	Q9UFN0	NPS3A_HUMAN	nipsnap homolog 3A	201						cytosol					0						GGTGGAATGAGAGTGCAGATA	0.388													0	0	0	0.001168	0	5	9										C	107521388	G	C	107521388	3	2	99	1	0	0	0	0	1	0	0	0	10430	933	33	1	621	1	NIPSNAP3A	9	107521388	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	11261560	107521388	33692043	206	30347										
TMEM38B	55151	broad.mit.edu	37	chr9	108457020	108457020	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttttgacatcgcgcactatCtagtgtcagtgatggcggtg	12	8	2	2	rs11542697		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:108457020C>G	uc004bcu.1	+	1	196	c.79C>G	c.(79-81)CTA>GTA	p.L27V	TMEM38B_uc010mtn.1_Missense_Mutation_p.L27V	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	27	Lumenal (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						CGCGCACTATCTAGTGTCAGT	0.602													0	0	0	0.009718	0	32	71										G	108457020	C	G	108457020	3	3	99	1	0	0	0	0	1	0	0	0	16157	912	32	1	81	1	TMEM38B	9	108457020	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	935632	108457020	32756411	207	30348										
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112900730	112900730	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagggaagaggagctgaagaGgcagagacaagtcttgcaga	16	5	1	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:112900730G>A	uc004bei.2	+	9	3794	c.3602G>A	c.(3601-3603)AGG>AAG	p.R1201K	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R969K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R969K|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R779K|AKAP2_uc011lwi.1_Missense_Mutation_p.R827K|AKAP2_uc004bem.2_Missense_Mutation_p.R827K|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R787K|AKAP2_uc011lwj.1_Missense_Mutation_p.R738K|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R738K	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	738	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GAGCTGAAGAGGCAGAGACAA	0.527													0	0	0	0.001855	0	11	45										A	112900730	G	A	112900730	3	1	99	1	0	0	0	0	1	0	0	0	11410	1000	35	2	2936	2	PALM2-AKAP2	9	112900730	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4443710	112900730	28312701	208	30349										
FKBP15	23307	broad.mit.edu	37	chr9	115959352	115959352	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catgcccagcattccatcctCccagccctttaaaaatcaga	4	16	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:115959352C>T	uc004bgs.2	-	9	842	c.724G>A	c.(724-726)GAG>AAG	p.E242K	FKBP15_uc010muu.1_Missense_Mutation_p.E306K|FKBP15_uc011lxd.1_Missense_Mutation_p.E174K|FKBP15_uc010mut.1_Missense_Mutation_p.E110K|FKBP15_uc004bgt.2_Missense_Mutation_p.E242K	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	242	PPIase FKBP-type.				endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						ATTCCATCCTCCCAGCCCTTT	0.463													0	0	0	0.003271	0	27	89										T	115959352	C	T	115959352	3	4	99	1	0	0	0	0	1	0	0	0	5905	864	30	1	3015	1	FKBP15	9	115959352	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3058622	115959352	25254079	209	30350										
COL27A1	85301	broad.mit.edu	37	chr9	117062947	117062947	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaaaggcatccagggccctCgggggccacctggcttgatg	14	13	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:117062947C>T	uc011lxl.1	+	51	4681	c.4681C>T	c.(4681-4683)CGG>TGG	p.R1561W	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1561	Collagen-like 15.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CCAGGGCCCTCGGGGGCCACC	0.622													0	0	0	0.006214	0	7	21										T	117062947	C	T	117062947	3	4	99	1	0	0	0	0	1	0	0	0	3685	875	31	1	4883	1	COL27A1	9	117062947	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1103595	117062947	24150484	210	30351										
SPTAN1	6709	broad.mit.edu	37	chr9	131340465	131340465	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagccctcatcaatgcagatGagcttgccagtgatgtggct	11	10	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:131340465G>T	uc004bvl.3	+	9	1275	c.1162G>T	c.(1162-1164)GAG>TAG	p.E388*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.E388*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.E400*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.E388*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.E388*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	388	Spectrin 5.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CAATGCAGATGAGCTTGCCAG	0.488													1	0	5.61819e-17	0.005443	6.08353e-17	21	40										T	131340465	G	T	131340465	4	4	99	1	0	0	0	0	0	1	0	0	15116	1291	45	3	1192	3	SPTAN1	9	131340465	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	14277518	131340465	9872966	211	30352										
FNBP1	23048	broad.mit.edu	37	chr9	132658267	132658267	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aactacggaaatcgttccttCattctgacctgaaaaagcaa	6	10	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:132658267C>T	uc004byw.1	-	16	1915	c.1696G>A	c.(1696-1698)GAA>AAA	p.E566K	FNBP1_uc011mbv.1_Missense_Mutation_p.E556K|FNBP1_uc011mbw.1_Missense_Mutation_p.E561K|FNBP1_uc004bza.2_Missense_Mutation_p.E500K|FNBP1_uc004byz.1_Missense_Mutation_p.E537K|FNBP1_uc004byv.1_5'Flank|FNBP1_uc011mbu.1_Missense_Mutation_p.E194K|FNBP1_uc004byx.1_Missense_Mutation_p.E482K|FNBP1_uc004byy.1_Missense_Mutation_p.E472K	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	566	Required for self-association and induction of membrane tubulation.|Interaction with FASLG.|SH3.|Interaction with PDE6G (By similarity).|Interaction with DNM1 and DNM3.|Required for interaction with TNKS.|Interaction with DNM2 and WASL.|Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		ATCGTTCCTTCATTCTGACCT	0.448			T	MLL	AML								0	0	0	0.010818	0	23	61										T	132658267	C	T	132658267	3	4	99	1	0	0	0	0	1	0	0	0	5965	835	29	1	165	1	FNBP1	9	132658267	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1317802	132658267	8555164	212	30353										
LAMC3	10319	broad.mit.edu	37	chr9	133948634	133948634	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcctcttctttctacaggaGattcctcaggaaggtcccag	8	12	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:133948634G>C	uc004caa.1	+	20	3518	c.3420G>C	c.(3418-3420)GAG>GAC	p.E1140D		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1140	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TTCTACAGGAGATTCCTCAGG	0.577													0	0	0	0.007413	0	15	33										C	133948634	G	C	133948634	3	2	99	1	0	0	0	0	1	0	0	0	8616	933	33	1	3498	1	LAMC3	9	133948634	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1290367	133948634	7264797	213	30354										
SARDH	1757	broad.mit.edu	37	chr9	136555522	136555522	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctggctgggccctggatactGatcatacccaggtcctcgga	12	13	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:136555522G>A	uc004cep.3	-	16	2183	c.2049C>T	c.(2047-2049)ATC>ATT	p.I683I	SARDH_uc004ceo.2_Silent_p.I683I|SARDH_uc011mdn.1_Silent_p.I683I|SARDH_uc011mdo.1_Silent_p.I515I|SARDH_uc004cen.2_Silent_p.I111I	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	683					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCTGGATACTGATCATACCCA	0.652													0	0	0	0.00499	0	14	37										A	136555522	G	A	136555522	2	1	99	1	0	0	0	0	0	0	0	1	13841	1280	45	1		1	SARDH	9	136555522	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2606888	136555522	4657909	214	30355										
C10orf18	54906	broad.mit.edu	37	chr10	5798582	5798582	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtaaatctttcagaaccttCtgaggaaaggaggccataca	9	8	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:5798582C>T	uc001iij.2	+	16	7238	c.6613C>T	c.(6613-6615)CTG>TTG	p.L2205L	C10orf18_uc001iik.2_Silent_p.L1049L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2205										ovary(1)|central_nervous_system(1)	2						TCAGAACCTTCTGAGGAAAGG	0.338													0	0	0	0.00333	0	17	36										T	5798582	C	T	5798582	2	4	99	1	0	0	0	0	0	0	0	1	1596	912	32	1		1	C10orf18	10	5798582	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		5798582	129736165	215	30356										
KIN	22944	broad.mit.edu	37	chr10	7829810	7829810	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggcactgcttctggcacatCtggcaataccagcgtagctt	10	13	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:7829810C>G	uc001ijt.2	-	1	135	c.87G>C	c.(85-87)CAG>CAC	p.Q29H	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.Q29H|KIN_uc010qba.1_5'UTR|ATP5C1_uc010qbb.1_5'Flank|ATP5C1_uc009xiq.1_5'Flank|ATP5C1_uc010qbc.1_5'Flank|ATP5C1_uc001iju.2_5'Flank|ATP5C1_uc001ijv.2_5'Flank	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	29	C2H2-type.				DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCTGGCACATCTGGCAATACC	0.627													0	0	0	0.01441	0	73	117										G	7829810	C	G	7829810	3	3	99	1	0	0	0	0	1	0	0	0	8315	912	32	1	1146	1	KIN	10	7829810	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2031228	7829810	127704937	216	30357										
SEPHS1	22929	broad.mit.edu	37	chr10	13361208	13361208	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtggtgcgacctcgatgatCcggggtttgtctatgattct	13	8	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:13361208C>G	uc001imk.2	-	9	1472	c.1113G>C	c.(1111-1113)CGG>CGC	p.R371R	SEPHS1_uc001imh.2_Silent_p.R295R|SEPHS1_uc010qbs.1_Silent_p.R323R|SEPHS1_uc001imi.2_Silent_p.R369R|SEPHS1_uc001imj.2_3'UTR|SEPHS1_uc010qbt.1_Silent_p.R304R	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	371					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						CCTCGATGATCCGGGGTTTGT	0.478													0	0	0	0.01441	0	79	195										G	13361208	C	G	13361208	2	3	99	1	0	0	0	0	0	0	0	1	14054	842	30	1		1	SEPHS1	10	13361208	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5531398	13361208	122173539	217	30358										
PIP4K2A	5305	broad.mit.edu	37	chr10	22830915	22830915	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccacttcctcctgttcggctCtctccacatcatgaattccc	4	18	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:22830915C>G	uc001irl.3	-	8	1102	c.854G>C	c.(853-855)AGA>ACA	p.R285T	PIP4K2A_uc010qcu.1_Missense_Mutation_p.R145T	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	285	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						CTGTTCGGCTCTCTCCACATC	0.607													0	0	0	0.004878	0	33	56										G	22830915	C	G	22830915	3	3	99	1	0	0	0	0	1	0	0	0	11936	913	32	1	378	1	PIP4K2A	10	22830915	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9469707	22830915	112703832	218	30359										
MPP7	143098	broad.mit.edu	37	chr10	28348590	28348590	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tccacatacttgttattttgTacatctgtctcaaacaaatg	4	9	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:28348590T>C	uc001iua.1	-	16	1691	c.1287A>G	c.(1285-1287)GTA>GTG	p.V429V	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.V429V|MPP7_uc009xla.2_Silent_p.V429V|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	429	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TGTTATTTTGTACATCTGTCT	0.358													0	0	0	0.009096	0	3	76										C	28348590	T	C	28348590	2	2	99	1	0	0	0	0	0	0	0	1	9739	1625	57	5		5	MPP7	10	28348590	Silent	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	5517675	28348590	107186157	219	30360										
ARHGAP12	94134	broad.mit.edu	37	chr10	32096725	32096725	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaacaattgctatactctgaTaggtcattcgatttttctct	5	8	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:32096725T>C	uc001ivz.1	-	20	2672	c.2402A>G	c.(2401-2403)TAT>TGT	p.Y801C	ARHGAP12_uc001ivy.1_Missense_Mutation_p.Y747C|ARHGAP12_uc009xls.2_Missense_Mutation_p.Y752C|ARHGAP12_uc001iwb.1_Missense_Mutation_p.Y794C|ARHGAP12_uc001iwc.1_Missense_Mutation_p.Y769C|ARHGAP12_uc009xlq.1_Missense_Mutation_p.Y722C|ARHGAP12_uc001ivw.1_RNA|ARHGAP12_uc001ivx.1_Missense_Mutation_p.Y100C	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	801	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TATACTCTGATAGGTCATTCG	0.328													0	0	0	0.00245	0	12	30										C	32096725	T	C	32096725	3	2	99	1	0	0	0	0	1	0	0	0	865	1406	49	5	142	5	ARHGAP12	10	32096725	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	3748135	32096725	103438022	220	30361										
RET	5979	broad.mit.edu	37	chr10	43619223	43619223	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccttctgaagaccggccaccGgatggagaggccagacaact	12	13	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:43619223G>A	uc001jal.2	+	17	3096	c.2906G>A	c.(2905-2907)CGG>CAG	p.R969Q	RET_uc001jak.1_Missense_Mutation_p.R969Q|RET_uc010qez.1_Missense_Mutation_p.R715Q	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	969	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ACCGGCCACCGGATGGAGAGG	0.597		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	0.009096	0	3	84										A	43619223	G	A	43619223	3	1	99	1	0	0	0	0	1	0	0	0	13235	1116	39	2	2972	2	RET	10	43619223	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	11522498	43619223	91915524	221	30362										
HNRNPF	3185	broad.mit.edu	37	chr10	43883167	43883167	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tccaagttcaacaaaagcctCaccactctgcctgccctctc	4	18	4	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:43883167C>G	uc009xmh.1	-	3	653	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	HNRNPF_uc001jar.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jas.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jat.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jav.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jau.2_Missense_Mutation_p.E56Q	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	56	RRM 1.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						ACAAAAGCCTCACCACTCTGC	0.493													0	0	0	0.010818	0	25	38										G	43883167	C	G	43883167	3	3	99	1	0	0	0	0	1	0	0	0	7265	835	29	1	1085	1	HNRNPF	10	43883167	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	263944	43883167	91651580	222	30363										
SLC18A3	6572	broad.mit.edu	37	chr10	50819359	50819359	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagggcctgggctcagccttCgccgacacgtctggcatagc	13	15	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:50819359C>T	uc001jhw.2	+	1	1013	c.573C>T	c.(571-573)TTC>TTT	p.F191F	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	191	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCTCAGCCTTCGCCGACACGT	0.657													0	0	0	0.00308	0	6	14										T	50819359	C	T	50819359	2	4	99	1	0	0	0	0	0	0	0	1	14427	883	31	1		1	SLC18A3	10	50819359	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	6936192	50819359	84715388	223	30364										
PCDH15	65217	broad.mit.edu	37	chr10	55581763	55581763	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gttctgaaacatttgtgcgtAgatagtttttttctatttga	8	4	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:55581763A>T	uc001jju.1	-	33	6118	c.5723T>A	c.(5722-5724)CTA>CAA	p.L1908Q	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.L762Q|PCDH15_uc010qhv.1_Missense_Mutation_p.L1905Q|PCDH15_uc010qhw.1_Missense_Mutation_p.L1868Q|PCDH15_uc010qhx.1_Missense_Mutation_p.L1839Q|PCDH15_uc010qhy.1_Missense_Mutation_p.L1915Q|PCDH15_uc010qhz.1_Missense_Mutation_p.L1910Q|PCDH15_uc010qia.1_Missense_Mutation_p.L1888Q|PCDH15_uc010qib.1_Missense_Mutation_p.L1885Q	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1908	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTTGTGCGTAGATAGTTTTT	0.358										HNSCC(58;0.16)			0	0	0	0.001168	0	5	63										T	55581763	A	T	55581763	3	4	99	1	0	0	0	0	1	0	0	0	11511	420	15	5	1754	5	PCDH15	10	55581763	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	4762404	55581763	79952984	224	30365										
DLG5	9231	broad.mit.edu	37	chr10	79590569	79590569	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtcaatggccgagtcgtggGagctgtgggccatcagctgt	16	9	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:79590569G>C	uc001jzk.2	-	10	1881	c.1811C>G	c.(1810-1812)TCC>TGC	p.S604C	DLG5_uc001jzj.2_Missense_Mutation_p.S359C|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.S208C	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	604					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CGAGTCGTGGGAGCTGTGGGC	0.567													0	0	0	0.010729	0	10	35										C	79590569	G	C	79590569	3	2	99	1	0	0	0	0	1	0	0	0	4558	1174	41	1	4040	1	DLG5	10	79590569	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	24008806	79590569	55944178	225	30366										
BTAF1	9044	broad.mit.edu	37	chr10	93778679	93778679	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaacatgcccctaagctctCagctttgaaacaagtatgta	6	11	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:93778679C>T	uc001khr.2	+	34	4948	c.4850C>T	c.(4849-4851)TCA>TTA	p.S1617L		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1617					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				CCTAAGCTCTCAGCTTTGAAA	0.353													0	0	0	0.006122	0	13	75										T	93778679	C	T	93778679	3	4	99	1	0	0	0	0	1	0	0	0	1536	838	29	1	4984	1	BTAF1	10	93778679	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	14188110	93778679	41756068	226	30367										
CNNM2	54805	broad.mit.edu	37	chr10	104679843	104679843	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccaagttggacgctatgctgGaagaatttaagaaaggtggg	14	5	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:104679843G>C	uc001kwm.2	+	1	1730	c.1606G>C	c.(1606-1608)GAA>CAA	p.E536Q	CNNM2_uc001kwn.2_Missense_Mutation_p.E536Q|CNNM2_uc001kwl.2_Missense_Mutation_p.E536Q	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	536	CBS 2.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CGCTATGCTGGAAGAATTTAA	0.463													0	0	0	0.012213	0	27	94										C	104679843	G	C	104679843	3	2	99	1	0	0	0	0	1	0	0	0	3613	1175	41	1	1608	1	CNNM2	10	104679843	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	10901164	104679843	30854904	227	30368										
CNNM2	54805	broad.mit.edu	37	chr10	104814140	104814140	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggaacgaaagcaagatttttCtgcctttaagcagacagaca	9	8	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:104814140C>G	uc001kwm.2	+	3	1944	c.1820C>G	c.(1819-1821)TCT>TGT	p.S607C	CNNM2_uc001kwn.2_Missense_Mutation_p.S607C	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	607					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAAGATTTTTCTGCCTTTAAG	0.433											OREG0020489	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	8	15										G	104814140	C	G	104814140	3	3	99	1	0	0	0	0	1	0	0	0	3613	913	32	1	1872	1	CNNM2	10	104814140	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	134297	104814140	30720607	228	30369										
MKI67	4288	broad.mit.edu	37	chr10	129899669	129899669	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctgcttctcctttccctttCtgattctgcatgagaacctt	5	14	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:129899669C>T	uc001lke.2	-	14	9753	c.9558G>A	c.(9556-9558)CAG>CAA	p.Q3186Q	MKI67_uc001lkf.2_Silent_p.Q2826Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	3186					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTTCCCTTTCTGATTCTGCA	0.507													0	0	0	0.004289	0	30	73										T	129899669	C	T	129899669	2	4	99	1	0	0	0	0	0	0	0	1	9598	912	32	1		1	MKI67	10	129899669	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	25085529	129899669	5635078	229	30370										
OR52I2	143502	broad.mit.edu	37	chr11	4608387	4608387	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccaagatggtgagcatcttCtgctcaggagacagctcaat	10	11	4	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:4608387C>T	uc010qyh.1	+	1	345	c.345C>T	c.(343-345)TTC>TTT	p.F115F		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	115	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGCATCTTCTGCTCAGGAG	0.512													0	0	0	0.01441	0	61	75										T	4608387	C	T	4608387	2	4	99	1	0	0	0	0	0	0	0	1	11121	912	32	1		1	OR52I2	11	4608387	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		4608387	130398129	230	30371										
OR52I2	143502	broad.mit.edu	37	chr11	4608419	4608419	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagctcaatcagctttagtgCttgtttcactcagatgtttt	7	9	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:4608419C>G	uc010qyh.1	+	1	377	c.377C>G	c.(376-378)GCT>GGT	p.A126G		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	126	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCTTTAGTGCTTGTTTCACT	0.517													0	0	0	0.004878	0	33	28										G	4608419	C	G	4608419	3	3	99	1	0	0	0	0	1	0	0	0	11121	797	28	4	379	4	OR52I2	11	4608419	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	32	4608419	130398097	231	30372										
TRIM5	85363	broad.mit.edu	37	chr11	5686256	5686256	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggggcacaatgaaaggaacaGaaggagtatggaaggaacta	15	4	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:5686256G>A	uc001mbm.1	-	8	1522	c.1265C>T	c.(1264-1266)TCT>TTT	p.S422F	TRIM78P_uc009yer.2_Intron|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Intron|TRIM5_uc001mbo.2_Intron	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	422	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		GAAAGGAACAGAAGGAGTATG	0.398													0	0	0	0.005524	0	34	34										A	5686256	G	A	5686256	3	1	99	1	0	0	0	0	1	0	0	0	16522	942	33	1	310	1	TRIM5	11	5686256	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1077837	5686256	129320260	232	30373										
DNHD1	144132	broad.mit.edu	37	chr11	6591874	6591874	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggagctggatgcaatggcaGagtgcaaggcccagatgcac	16	9	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:6591874G>C	uc001mdw.3	+	42	13696	c.13132G>C	c.(13132-13134)GAG>CAG	p.E4378Q	DNHD1_uc001mea.3_Missense_Mutation_p.E647Q|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.E646Q|DNHD1_uc010rao.1_Missense_Mutation_p.E636Q|DNHD1_uc009yfg.2_Missense_Mutation_p.E3Q	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4378					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGCAATGGCAGAGTGCAAGGC	0.617													0	0	0	0.004672	0	2	7										C	6591874	G	C	6591874	3	2	99	1	0	0	0	0	1	0	0	0	4668	943	33	1	13299	1	DNHD1	11	6591874	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	905618	6591874	128414642	233	30374										
EIF4G2	1982	broad.mit.edu	37	chr11	10821737	10821737	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgctgaagacaaagtaggaaGagaggaaaatgggtgccact	14	5	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:10821737G>C	uc001mjc.2	-	18	2436	c.2019C>G	c.(2017-2019)CTC>CTG	p.L673L	EIF4G2_uc001mjb.2_Silent_p.L467L|EIF4G2_uc009ygf.2_Silent_p.L467L|EIF4G2_uc001mjd.2_Silent_p.L635L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	673					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAAGTAGGAAGAGAGGAAAAT	0.413													0	0	0	0.003163	0	15	13										C	10821737	G	C	10821737	2	2	99	1	0	0	0	0	0	0	0	1	5037	929	33	1		1	EIF4G2	11	10821737	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4229863	10821737	124184779	234	30375										
E2F8	79733	broad.mit.edu	37	chr11	19253898	19253898	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	actcagaacattagctatatCatacaacctcctaatttttg	3	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:19253898C>T	uc001mpm.2	-	7	1471	c.949G>A	c.(949-951)GAT>AAT	p.D317N	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.D317N	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	317	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TTAGCTATATCATACAACCTC	0.358													0	0	0	0.003271	0	30	61										T	19253898	C	T	19253898	3	4	99	1	0	0	0	0	1	0	0	0	4873	826	29	1	1682	1	E2F8	11	19253898	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	8432161	19253898	115752618	235	30376										
PDHX	8050	broad.mit.edu	37	chr11	35006268	35006268	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tatccaggaaattgctgactCtgtaaaggtatgtcttaaga	9	6	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:35006268C>G	uc001mvt.2	+	9	1701	c.1175C>G	c.(1174-1176)TCT>TGT	p.S392C	PDHX_uc010rep.1_Missense_Mutation_p.S377C|PDHX_uc010req.1_Missense_Mutation_p.S165C	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	392					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			ATTGCTGACTCTGTAAAGGTA	0.358													0	0	0	0.01441	0	51	111										G	35006268	C	G	35006268	3	3	99	1	0	0	0	0	1	0	0	0	11667	913	32	1	1328	1	PDHX	11	35006268	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	15752370	35006268	100000248	236	30377										
LRP4	4038	broad.mit.edu	37	chr11	46914632	46914632	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctcaatcctcgaggtgcctGagtcggtccagtagagtttg	12	11	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:46914632G>A	uc001ndn.3	-	13	1735	c.1589C>T	c.(1588-1590)TCA>TTA	p.S530L		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	530	Extracellular (Potential).|LDL-receptor class B 2.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CGAGGTGCCTGAGTCGGTCCA	0.592													0	0	0	0.004007	0	8	33										A	46914632	G	A	46914632	3	1	99	1	0	0	0	0	1	0	0	0	8959	1294	45	1	4232	1	LRP4	11	46914632	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	11908364	46914632	88091884	237	30378										
FNBP4	23360	broad.mit.edu	37	chr11	47754150	47754150	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcatactgttttagttgttCtgctgcatcctgaagttttc	7	8	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:47754150C>T	uc009ylv.2	-	11	1912	c.1759G>A	c.(1759-1761)GAA>AAA	p.E587K	FNBP4_uc001ngj.2_Missense_Mutation_p.E494K|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	587										ovary(1)	1						TTTAGTTGTTCTGCTGCATCC	0.443													0	0	0	0.00632	0	28	63										T	47754150	C	T	47754150	3	4	99	1	0	0	0	0	1	0	0	0	5967	922	32	1	1322	1	FNBP4	11	47754150	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	839518	47754150	87252366	238	30379										
OR4C3	256144	broad.mit.edu	37	chr11	48346641	48346641	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acagaactcagaggtacagaGagttctctttgtggtctttt	10	7	3	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:48346641G>C	uc010rhv.1	+	1	149	c.149G>C	c.(148-150)AGA>ACA	p.R50T		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAGGTACAGAGAGTTCTCTTT	0.478													0	0	0	0.007835	0	32	52										C	48346641	G	C	48346641	3	2	99	1	0	0	0	0	1	0	0	0	11050	942	33	1	151	1	OR4C3	11	48346641	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	592491	48346641	86659875	239	30380										
OR5M11	219487	broad.mit.edu	37	chr11	56310058	56310058	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tccctctgctgatttgatccGgaggatggcagcaagaatga	12	9	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:56310058G>A	uc010rjl.1	-	1	676	c.676C>T	c.(676-678)CGG>TGG	p.R226W		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATTTGATCCGGAGGATGGCA	0.493													0	0	0	0.003954	0	23	48										A	56310058	G	A	56310058	3	1	99	1	0	0	0	0	1	0	0	0	11174	1115	39	2	244	2	OR5M11	11	56310058	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7963417	56310058	78696458	240	30381										
TMX2	51075	broad.mit.edu	37	chr11	57480128	57480128	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctaattgctctcgtgtattCggtgccgcgactttcacgat	9	11	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:57480128C>T	uc001nlc.1	+	1	87	c.38C>T	c.(37-39)TCG>TTG	p.S13L	CTNND1_uc001nlf.1_5'UTR|MED19_uc001nla.1_5'Flank|MED19_uc001nlb.2_5'Flank|TMX2_uc001nld.1_5'UTR|TMX2_uc001nle.1_Missense_Mutation_p.S13L	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	13					cell redox homeostasis	integral to membrane					0						CTCGTGTATTCGGTGCCGCGA	0.622													0	0	0	0.003163	0	10	31										T	57480128	C	T	57480128	3	4	99	1	0	0	0	0	1	0	0	0	16264	893	31	1	40	1	TMX2	11	57480128	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1170070	57480128	77526388	241	30382										
VEGFB	7423	broad.mit.edu	37	chr11	64002948	64002948	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggcccctgtctcccagcctGatgcccctggccaccagagg	11	18	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:64002948G>A	uc001nyw.2	+	2	119	c.79G>A	c.(79-81)GAT>AAT	p.D27N	VEGFB_uc001nyx.2_Missense_Mutation_p.D27N	NM_003377	NP_003368	P49765	VEGFB_HUMAN	vascular endothelial growth factor B precursor	27					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0						CTCCCAGCCTGATGCCCCTGG	0.552													0	0	0	0.007291	0	23	49										A	64002948	G	A	64002948	3	1	99	1	0	0	0	0	1	0	0	0	17148	1290	45	1	85	1	VEGFB	11	64002948	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	6522820	64002948	71003568	242	30383										
PYGM	5837	broad.mit.edu	37	chr11	64514251	64514251	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccagaggtggctatgttccgGatcaccatccgcgtccactc	10	15	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:64514251G>A	uc001oax.3	-	20	3226	c.2409C>T	c.(2407-2409)ATC>ATT	p.I803I	RASGRP2_uc009ypu.2_5'Flank|RASGRP2_uc009ypv.2_5'Flank|RASGRP2_uc009ypw.2_5'Flank|RASGRP2_uc001oaw.1_5'Flank|PYGM_uc001oay.3_Silent_p.I715I	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	803					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CTATGTTCCGGATCACCATCC	0.607													0	0	0	0.01441	0	41	58										A	64514251	G	A	64514251	2	1	99	1	0	0	0	0	0	0	0	1	12862	1164	41	1		1	PYGM	11	64514251	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	511303	64514251	70492265	243	30384										
FOSL1	8061	broad.mit.edu	37	chr11	65664326	65664326	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctggaggcggccccagggccCggatgactcctggccggggt	18	14	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:65664326C>A	uc001ogg.1	-	2	438	c.251G>T	c.(250-252)CGG>CTG	p.R84L	FOSL1_uc010ros.1_Intron	NM_005438	NP_005429	P15407	FOSL1_HUMAN	FOS-like antigen 1	84					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				READ - Rectum adenocarcinoma(159;0.168)		CCCCAGGGCCCGGATGACTCC	0.647													1	0	4.7796e-09	0.004656	5.04305e-09	22	64										A	65664326	C	A	65664326	3	1	99	1	0	0	0	0	1	0	0	0	5987	652	23	4	576	4	FOSL1	11	65664326	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1150075	65664326	69342190	244	30385										
DPP3	10072	broad.mit.edu	37	chr11	66272178	66272178	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccgagtgcttcctcaccctCagggacacggtgctgctgcg	12	16	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:66272178C>T	uc001oig.1	+	17	2036	c.1974C>T	c.(1972-1974)CTC>CTT	p.L658L	DPP3_uc001oif.1_Silent_p.L658L|DPP3_uc010rpe.1_Silent_p.L647L|DPP3_uc001oih.1_Missense_Mutation_p.S26L	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	658					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TCCTCACCCTCAGGGACACGG	0.597													0	0	0	0.00632	0	24	91										T	66272178	C	T	66272178	2	4	99	1	0	0	0	0	0	0	0	1	4728	813	29	1		1	DPP3	11	66272178	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	607852	66272178	68734338	245	30386										
CABP4	57010	broad.mit.edu	37	chr11	67223206	67223206	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgacatcgtcctgactccctGcacgacgctgctcagaggac	10	16	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67223206G>T	uc001olo.2	+	1	389	c.312G>T	c.(310-312)CTG>CTT	p.L104L	CABP4_uc001oln.2_5'UTR	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	104					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CTGACTCCCTGCACGACGCTG	0.677													1	0	2.56e-06	0.009096	2.65408e-06	3	22										T	67223206	G	T	67223206	2	4	99	1	0	0	0	0	0	0	0	1	2533	1306	46	4		4	CABP4	11	67223206	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	951028	67223206	67783310	246	30387										
CABP2	51475	broad.mit.edu	37	chr11	67287568	67287568	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggacaccgatcatgtctgccGtctctgccagcagcttgggg	13	13	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67287568G>C	uc001omc.1	-	5	545	c.443C>G	c.(442-444)ACG>AGG	p.T148R	CABP2_uc001omd.1_Missense_Mutation_p.T91R|CABP2_uc001ome.1_Missense_Mutation_p.T154R	NM_016366	NP_057450	Q9NPB3	CABP2_HUMAN	calcium binding protein 2 isoform 1	148					signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1						CATGTCTGCCGTCTCTGCCAG	0.657													0	0	0	0.010504	0	16	68										C	67287568	G	C	67287568	3	2	99	1	0	0	0	0	1	0	0	0	2532	1145	40	4	231	4	CABP2	11	67287568	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	64362	67287568	67718948	247	30388										
ALDH3B1	221	broad.mit.edu	37	chr11	67789327	67789327	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggggccagagcgatgagagcGatcgctacatcggtgagtcc	16	10	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67789327G>A	uc010rpy.1	+	9	1053	c.937G>A	c.(937-939)GAT>AAT	p.D313N	ALDH3B1_uc001omz.2_Missense_Mutation_p.D313N|ALDH3B1_uc001ona.2_Missense_Mutation_p.D276N|ALDH3B1_uc001onb.2_RNA	NM_001161473	NP_001154945	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3B1 isoform a	313					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase				0					NADH(DB00157)	CGATGAGAGCGATCGCTACAT	0.657													0	0	0	0.01441	0	44	46										A	67789327	G	A	67789327	3	1	99	1	0	0	0	0	1	0	0	0	499	1045	37	1	957	1	ALDH3B1	11	67789327	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	501759	67789327	67217189	248	30389										
FOLR3	2352	broad.mit.edu	37	chr11	71850770	71850770	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggagcggccgctgcatccaGatgtggtttgactcagccca	14	12	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:71850770G>C	uc001ory.1	+	5	809	c.759G>C	c.(757-759)CAG>CAC	p.Q253H	FOLR3_uc001orx.1_Missense_Mutation_p.Q211H			P41439	FOLR3_HUMAN	SubName: Full=FOLR3 protein; Flags: Fragment;	209					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity				0					Folic Acid(DB00158)	GCTGCATCCAGATGTGGTTTG	0.577													0	0	0	0.010729	0	11	51										C	71850770	G	C	71850770	3	2	99	1	0	0	0	0	1	0	0	0	5983	933	33	1	645	1	FOLR3	11	71850770	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4061443	71850770	63155746	249	30390										
ANKRD42	338699	broad.mit.edu	37	chr11	82938902	82938902	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtgctgataatggatcaactCctatgcataaaggtgagtta	10	6	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:82938902C>G	uc001ozz.1	+	7	1239	c.817C>G	c.(817-819)CCT>GCT	p.P273A	ANKRD42_uc010rsv.1_Missense_Mutation_p.P301A|ANKRD42_uc001paa.2_Missense_Mutation_p.P301A|ANKRD42_uc001pab.1_Missense_Mutation_p.P300A	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	273	ANK 8.									skin(1)	1						TGGATCAACTCCTATGCATAA	0.373													0	0	0	0.009718	0	35	101										G	82938902	C	G	82938902	3	3	99	1	0	0	0	0	1	0	0	0	670	855	30	1	843	1	ANKRD42	11	82938902	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	11088132	82938902	52067614	250	30391										
CCDC83	220047	broad.mit.edu	37	chr11	85630484	85630484	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caagagaaggaaattccagtCaaactctataaagatgtcag	8	7	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:85630484C>G	uc001pbh.1	+	11	1685	c.1173C>G	c.(1171-1173)GTC>GTG	p.V391V	CCDC83_uc001pbg.1_Silent_p.V422V|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Silent_p.V291V	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	391										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AAATTCCAGTCAAACTCTATA	0.413													0	0	0	0.006122	0	16	39										G	85630484	C	G	85630484	2	3	99	1	0	0	0	0	0	0	0	1	2857	813	29	1		1	CCDC83	11	85630484	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2691582	85630484	49376032	251	30392										
TYR	7299	broad.mit.edu	37	chr11	88924428	88924428	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtctttatgcaatggaacgcCcgagggacctttacggcgta	12	10	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:88924428C>T	uc001pcs.2	+	2	960	c.878C>T	c.(877-879)CCC>CTC	p.P293L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	293	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	AATGGAACGCCCGAGGGACCT	0.473									Oculocutaneous_Albinism				0	0	0	0.00623	0	34	79										T	88924428	C	T	88924428	3	4	99	1	0	0	0	0	1	0	0	0	16810	623	22	2	884	2	TYR	11	88924428	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3293944	88924428	46082088	252	30393										
JRKL	8690	broad.mit.edu	37	chr11	96124929	96124929	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctttatgaaatagcaatggcAtggaacttagtaaaaccagt	8	6	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:96124929A>G	uc009ywu.2	+	2	1368	c.1116A>G	c.(1114-1116)GCA>GCG	p.A372A	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Silent_p.A372A	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	372	DDE.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		TAGCAATGGCATGGAACTTAG	0.408													0	0	0	0.000602	0	3	134										G	96124929	A	G	96124929	2	3	99	1	0	0	0	0	0	0	0	1	7965	204	8	5		5	JRKL	11	96124929	Silent	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	7200501	96124929	38881587	253	30394										
PDGFD	80310	broad.mit.edu	37	chr11	104034599	104034599	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgcggggttgcagaagtgtcCcgacagctgcaaaagtttgc	14	9	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:104034599C>T	uc001phq.2	-	1	429	c.57G>A	c.(55-57)CGG>CGA	p.R19R	PDGFD_uc001php.2_Silent_p.R19R	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	19					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CAGAAGTGTCCCGACAGCTGC	0.488											OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	5	34										T	104034599	C	T	104034599	2	4	99	1	0	0	0	0	0	0	0	1	11660	610	22	2		2	PDGFD	11	104034599	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	7909670	104034599	30971917	254	30395										
KBTBD3	143879	broad.mit.edu	37	chr11	105924026	105924026	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gttaaaagcatctgtaatctCtacctctgatccaagaacat	5	10	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:105924026C>G	uc001pja.2	-	4	2030	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	KBTBD3_uc001pjb.2_Missense_Mutation_p.E464Q|KBTBD3_uc009yxm.2_Missense_Mutation_p.E385Q	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	460	Kelch 4.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCTGTAATCTCTACCTCTGAT	0.373													0	0	0	0.00632	0	25	28										G	105924026	C	G	105924026	3	3	99	1	0	0	0	0	1	0	0	0	7994	922	32	1	452	1	KBTBD3	11	105924026	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1889427	105924026	29082490	255	30396										
ATM	472	broad.mit.edu	37	chr11	108236064	108236064	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtccttagtgatattgaccaGagtttcaacaaagtagctga	9	7	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236064G>C	uc001pkb.1	+	63	9385	c.9000G>C	c.(8998-9000)CAG>CAC	p.Q3000H	ATM_uc009yxr.1_Missense_Mutation_p.Q3000H|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.Q1652H	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3000					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATATTGACCAGAGTTTCAACA	0.403			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.014323	0	15	60										C	108236064	G	C	108236064	3	2	99	1	0	0	0	0	1	0	0	0	1109	933	33	1	9246	1	ATM	11	108236064	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2312038	108236064	26770452	256	30397			2	132		4	4	97	G		4.443011e-10
ATM	472	broad.mit.edu	37	chr11	108236083	108236083	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agagtttcaacaaagtagctGaacgtgtcttaatgagacta	9	6	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236083G>A	uc001pkb.1	+	63	9404	c.9019G>A	c.(9019-9021)GAA>AAA	p.E3007K	ATM_uc009yxr.1_Missense_Mutation_p.E3007K|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E1659K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3007					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CAAAGTAGCTGAACGTGTCTT	0.413			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.007291	0	17	65										A	108236083	G	A	108236083	3	1	99	1	0	0	0	0	1	0	0	0	1109	1291	45	1	9265	1	ATM	11	108236083	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	19	108236083	26770433	257	30398			2	132		4	4	97	G		4.443011e-10
ATM	472	broad.mit.edu	37	chr11	108236128	108236128	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agaaactgaaaggagtggaaGaaggcactgtgctcagtgtt	14	5	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236128G>T	uc001pkb.1	+	63	9449	c.9064G>T	c.(9064-9066)GAA>TAA	p.E3022*	ATM_uc009yxr.1_Nonsense_Mutation_p.E3022*|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Nonsense_Mutation_p.E1674*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3022					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGGAGTGGAAGAAGGCACTGT	0.433			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			1	0	3.01185e-09	0.003954	3.18412e-09	17	59										T	108236128	G	T	108236128	4	4	99	1	0	0	0	0	0	1	0	0	1109	943	33	3	9310	3	ATM	11	108236128	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	45	108236128	26770388	258	30399			2	132		4	4	97	G		4.443011e-10
ATM	472	broad.mit.edu	37	chr11	108236160	108236160	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctcagtgttggtggacaagtGaatttgctcatacagcaggc	12	8	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236160G>A	uc001pkb.1	+	63	9481	c.9096G>A	c.(9094-9096)GTG>GTA	p.V3032V	ATM_uc009yxr.1_Silent_p.V3032V|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.V1684V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3032	FATC.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGGACAAGTGAATTTGCTCA	0.443			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.00499	0	12	41										A	108236160	G	A	108236160	2	1	99	1	0	0	0	0	0	0	0	1	1109	1277	45	1		1	ATM	11	108236160	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	32	108236160	26770356	259	30400			2	132		4	4	97	G		4.443011e-10
ARHGAP20	57569	broad.mit.edu	37	chr11	110582892	110582892	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcgagccgagacactcctgtCagggaagaggagcgccccgg	16	13	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:110582892C>T	uc001pkz.1	-	2	348	c.63G>A	c.(61-63)CTG>CTA	p.L21L	ARHGAP20_uc001pky.1_5'Flank|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	21					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ACACTCCTGTCAGGGAAGAGG	0.473													0	0	0	0.006214	0	7	13										T	110582892	C	T	110582892	2	4	99	1	0	0	0	0	0	0	0	1	870	813	29	1		1	ARHGAP20	11	110582892	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2346732	110582892	24423624	260	30401										
ZW10	9183	broad.mit.edu	37	chr11	113608339	113608339	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acctcagaaattgctgtattGagtaaagtccccatagcctt	7	10	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:113608339G>C	uc001poe.2	-	14	2008	c.1971C>G	c.(1969-1971)CTC>CTG	p.L657L	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	657					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TTGCTGTATTGAGTAAAGTCC	0.433													0	0	0	0.01441	0	38	92										C	113608339	G	C	113608339	2	2	99	1	0	0	0	0	0	0	0	1	18244	1277	45	1		1	ZW10	11	113608339	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3025447	113608339	21398177	261	30402										
DSCAML1	57453	broad.mit.edu	37	chr11	117306394	117306394	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agccgtttctccttcctcttCttgcgtacgatgaagagcag	9	12	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:117306394C>T	uc001prh.1	-	27	5024	c.5022G>A	c.(5020-5022)AAG>AAA	p.K1674K		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1614	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCTTCCTCTTCTTGCGTACGA	0.597													0	0	0	0.003954	0	21	54										T	117306394	C	T	117306394	2	4	99	1	0	0	0	0	0	0	0	1	4769	912	32	1		1	DSCAML1	11	117306394	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3698055	117306394	17700122	262	30403										
GRAMD1B	57476	broad.mit.edu	37	chr11	123448178	123448178	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggacggagacaccatggtgGagaagggctcagatcactcc	14	10	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:123448178G>C	uc001pyx.2	+	2	456	c.127G>C	c.(127-129)GAG>CAG	p.E43Q	GRAMD1B_uc001pyw.2_Missense_Mutation_p.E43Q|GRAMD1B_uc010rzw.1_Missense_Mutation_p.E3Q|GRAMD1B_uc010rzx.1_Missense_Mutation_p.E3Q|GRAMD1B_uc009zbe.1_Missense_Mutation_p.E39Q	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	43						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		CACCATGGTGGAGAAGGGCTC	0.677											OREG0021454	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	6										C	123448178	G	C	123448178	3	2	99	1	0	0	0	0	1	0	0	0	6748	1175	41	1	133	1	GRAMD1B	11	123448178	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	6141784	123448178	11558338	263	30404										
C11orf61	79684	broad.mit.edu	37	chr11	124637361	124637361	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggtgggttctatttccaccTgtaatgaggcttgtgctgaa	13	7	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:124637361T>C	uc001qba.1	-	4	1414	c.1391A>G	c.(1390-1392)CAG>CGG	p.Q464R	C11orf61_uc001qaz.1_Missense_Mutation_p.Q412R|C11orf61_uc010sap.1_Missense_Mutation_p.Q184R|C11orf61_uc001qay.1_Missense_Mutation_p.Q234R	NM_024631	NP_078907	Q6P1R3	CK061_HUMAN	hypothetical protein LOC79684	464											0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0079)		TATTTCCACCTGTAATGAGGC	0.498													0	0	0	0.004672	0	3	134										C	124637361	T	C	124637361	3	2	99	1	0	0	0	0	1	0	0	0	1653	1580	55	5	292	5	C11orf61	11	124637361	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	1189183	124637361	10369155	264	30405										
CDON	50937	broad.mit.edu	37	chr11	125859579	125859579	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	taaattcactttctcctcctTcattgaagcattgcatttta	3	10	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:125859579T>G	uc009zbw.2	-	15	2854	c.2726A>C	c.(2725-2727)GAA>GCA	p.E909A	CDON_uc001qdb.3_Missense_Mutation_p.E286A|CDON_uc001qdc.3_Missense_Mutation_p.E909A	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	909	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TTCTCCTCCTTCATTGAAGCA	0.403													0	0	0	0.001168	0	5	110										G	125859579	T	G	125859579	3	3	99	1	0	0	0	0	1	0	0	0	3170	1783	62	5	1092	5	CDON	11	125859579	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	1222218	125859579	9146937	265	30406										
ARHGAP32	9743	broad.mit.edu	37	chr11	128839034	128839034	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcacactgctctggcgcttgCcgtgtggttggtactggtac	13	11	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:128839034C>A	uc009zcp.2	-	22	6032	c.6032G>T	c.(6031-6033)GGC>GTC	p.G2011V	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.G970V|ARHGAP32_uc001qez.2_Missense_Mutation_p.G1662V	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2011	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CTGGCGCTTGCCGTGTGGTTG	0.572													1	0	6.44725e-10	0.014323	6.8566e-10	19	55										A	128839034	C	A	128839034	3	1	99	1	0	0	0	0	1	0	0	0	881	739	26	4	235	4	ARHGAP32	11	128839034	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2979455	128839034	6167482	266	30407										
IGSF9B	22997	broad.mit.edu	37	chr11	133816031	133816031	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatggggaccccgaacttgaAccactctacgacatagggtg	12	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:133816031A>T	uc001qgx.3	-	2	418	c.187T>A	c.(187-189)TTC>ATC	p.F63I	IGSF9B_uc001qgz.2_RNA	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	63	Extracellular (Potential).|Ig-like 1.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCGAACTTGAACCACTCTACG	0.612													0	0	0	0.00245	0	13	21										T	133816031	A	T	133816031	3	4	99	1	0	0	0	0	1	0	0	0	7606	43	2	5	3934	5	IGSF9B	11	133816031	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	4976997	133816031	1190485	267	30408										
CACNA1C	775	broad.mit.edu	37	chr12	2788756	2788756	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	actgagtcgccatcccacgaGaagctggtggactccacctt	10	14	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:2788756G>A	uc009zdu.1	+	44	5695	c.5382G>A	c.(5380-5382)GAG>GAA	p.E1794E	CACNA1C_uc009zdv.1_Silent_p.E1743E|CACNA1C_uc001qkb.2_Silent_p.E1746E|CACNA1C_uc001qkc.2_Silent_p.E1765E|CACNA1C_uc001qke.2_Silent_p.E1735E|CACNA1C_uc001qkf.2_Silent_p.E1754E|CACNA1C_uc001qjz.2_Silent_p.E1746E|CACNA1C_uc001qkd.2_Silent_p.E1765E|CACNA1C_uc001qkg.2_Silent_p.E1752E|CACNA1C_uc009zdw.1_Silent_p.E1787E|CACNA1C_uc001qkh.2_Silent_p.E1754E|CACNA1C_uc001qkl.2_Silent_p.E1794E|CACNA1C_uc001qkn.2_Silent_p.E1746E|CACNA1C_uc001qko.2_Silent_p.E1766E|CACNA1C_uc001qkp.2_Silent_p.E1746E|CACNA1C_uc001qkr.2_Silent_p.E1763E|CACNA1C_uc001qku.2_Silent_p.E1746E|CACNA1C_uc001qkq.2_Silent_p.E1774E|CACNA1C_uc001qks.2_Silent_p.E1746E|CACNA1C_uc001qkt.2_Silent_p.E1765E|CACNA1C_uc001qki.1_Silent_p.E1482E|CACNA1C_uc001qkj.1_Silent_p.E1482E|CACNA1C_uc001qkk.1_Silent_p.E1482E|CACNA1C_uc001qkm.1_Silent_p.E1471E|CACNA1C_uc010sea.1_Silent_p.E437E|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Silent_p.E64E	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1794	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATCCCACGAGAAGCTGGTGG	0.657													0	0	0	0.013537	0	11	24										A	2788756	G	A	2788756	2	1	99	1	0	0	0	0	0	0	0	1	2540	933	33	1		1	CACNA1C	12	2788756	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		2788756	131063139	268	30409										
CLEC4C	170482	broad.mit.edu	37	chr12	7883463	7883463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accccctggatctgacagccCcagaaaataagaagaatttc	7	12	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:7883463C>T	uc001qtg.1	-	5	601	c.427G>A	c.(427-429)GGG>AGG	p.G143R	CLEC4C_uc001qth.1_Missense_Mutation_p.G143R|CLEC4C_uc001qti.1_Missense_Mutation_p.G112R	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	143	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		TCTGACAGCCCCAGAAAATAA	0.378													0	0	0	0.005524	0	33	76										T	7883463	C	T	7883463	3	4	99	1	0	0	0	0	1	0	0	0	3513	623	22	2	222	2	CLEC4C	12	7883463	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5094707	7883463	125968432	269	30410										
SLCO1C1	53919	broad.mit.edu	37	chr12	20874807	20874807	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcttggctatctaatagcagGaatcataagtcttcttgcag	9	8	4	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:20874807G>T	uc001rej.3	+	9	1200	c.845G>T	c.(844-846)GGA>GTA	p.G282V	SLCO1C1_uc010sii.1_Missense_Mutation_p.G282V|SLCO1C1_uc010sij.1_Missense_Mutation_p.G233V|SLCO1C1_uc009zip.2_Missense_Mutation_p.G116V|SLCO1C1_uc001rei.2_Missense_Mutation_p.G282V|SLCO1C1_uc010sik.1_Missense_Mutation_p.G164V	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	282	Helical; Name=6; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CTAATAGCAGGAATCATAAGT	0.438													1	0	8.34094e-07	0.008871	8.69794e-07	19	31										T	20874807	G	T	20874807	3	4	99	1	0	0	0	0	1	0	0	0	14725	1174	41	3	871	3	SLCO1C1	12	20874807	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	12991344	20874807	112977088	270	30411										
SLCO1B1	10599	broad.mit.edu	37	chr12	21355522	21355522	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gttggaattgccaaattctcAtgttttactgctgtgatgtc	9	7	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:21355522A>G	uc001req.3	+	10	1337	c.1233A>G	c.(1231-1233)TCA>TCG	p.S411S		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	411	Helical; Name=9; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CCAAATTCTCATGTTTTACTG	0.343													0	0	0	0.004007	0	16	23										G	21355522	A	G	21355522	2	3	99	1	0	0	0	0	0	0	0	1	14723	204	8	5		5	SLCO1B1	12	21355522	Silent	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	480715	21355522	112496373	271	30412										
C12orf72	254013	broad.mit.edu	37	chr12	31820829	31820829	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtggacacagcattcagcatCacctgcacaaagtggtagaa	10	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:31820829C>T	uc009zjr.2	+	4	903	c.694C>T	c.(694-696)CAC>TAC	p.H232Y	C12orf72_uc001rkl.2_Missense_Mutation_p.H232Y|C12orf72_uc001rkm.2_Missense_Mutation_p.H232Y	NM_001135864	NP_001129336	Q8IXQ9	MET20_HUMAN	hypothetical protein LOC254013	232						cytoplasm	protein methyltransferase activity				0						CATTCAGCATCACCTGCACAA	0.488													0	0	0	0.006999	0	30	59										T	31820829	C	T	31820829	3	4	99	1	0	0	0	0	1	0	0	0	1713	826	29	1	704	1	C12orf72	12	31820829	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	10465307	31820829	102031066	272	30413										
LMBR1L	55716	broad.mit.edu	37	chr12	49498238	49498238	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atcccctacttacctttctgGagccagcaaagccctcagac	6	16	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:49498238G>A	uc001rth.3	-	5	770	c.428C>T	c.(427-429)TCC>TTC	p.S143F	LMBR1L_uc001rtg.3_Missense_Mutation_p.S138F|LMBR1L_uc001rti.3_Missense_Mutation_p.S143F|LMBR1L_uc001rtj.1_5'Flank|LMBR1L_uc009zld.1_Missense_Mutation_p.S16F|LMBR1L_uc010smf.1_RNA	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	143	Cytoplasmic (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1						TACCTTTCTGGAGCCAGCAAA	0.299													0	0	0	0.01441	0	54	132										A	49498238	G	A	49498238	3	1	99	1	0	0	0	0	1	0	0	0	8841	1174	41	1	1093	1	LMBR1L	12	49498238	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	17677409	49498238	84353657	273	30414										
BCDIN3D	144233	broad.mit.edu	37	chr12	50232586	50232586	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaacgtccaaattggcttaaGaaagagctcaagagaacctt	9	8	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:50232586G>A	uc001rvh.2	-	2	489	c.447C>T	c.(445-447)TTC>TTT	p.F149F	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	149	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						ATTGGCTTAAGAAAGAGCTCA	0.443											OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	21	47										A	50232586	G	A	50232586	2	1	99	1	0	0	0	0	0	0	0	1	1357	933	33	1		1	BCDIN3D	12	50232586	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	734348	50232586	83619309	274	30415										
GRASP	160622	broad.mit.edu	37	chr12	52403023	52403023	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccagagtcctgaacagcagcGgtgagtcaccaacacccagc	10	15	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:52403023G>A	uc001rzo.1	+	2	352	c.296G>A	c.(295-297)CGG>CAG	p.R99Q	GRASP_uc001rzp.1_5'Flank	NM_181711	NP_859062	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides	99						cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GAACAGCAGCGGTGAGTCACC	0.597													0	0	0	0.00623	0	37	75										A	52403023	G	A	52403023	3	1	99	1	0	0	0	0	1	0	0	0	6755	1130	39	2	302	2	GRASP	12	52403023	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2170437	52403023	81448872	275	30416										
KRT2	3849	broad.mit.edu	37	chr12	53045825	53045825	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagaagctggaagttgatctCcggcttccaccagacaccac	10	13	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:53045825C>G	uc001sat.2	-	1	135	c.102G>C	c.(100-102)CGG>CGC	p.R34R		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	34	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		AAGTTGATCTCCGGCTTCCAC	0.522													0	0	0	0.00245	0	10	20										G	53045825	C	G	53045825	2	3	99	1	0	0	0	0	0	0	0	1	8457	842	30	1		1	KRT2	12	53045825	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	642802	53045825	80806070	276	30417										
RARG	5916	broad.mit.edu	37	chr12	53621231	53621231	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcgaaaggcggagaccccctGagtgcccctgggaaggcgaa	15	12	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:53621231G>A	uc001sce.2	-	3	584	c.99C>T	c.(97-99)CTC>CTT	p.L33L	RARG_uc001scf.2_Silent_p.L33L|RARG_uc001scg.2_Intron|RARG_uc010soc.1_Intron	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	33	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GAGACCCCCTGAGTGCCCCTG	0.647													0	0	0	0.001984	0	6	14										A	53621231	G	A	53621231	2	1	99	1	0	0	0	0	0	0	0	1	13054	1277	45	1		1	RARG	12	53621231	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	575406	53621231	80230664	277	30418										
STAC3	246329	broad.mit.edu	37	chr12	57637672	57637672	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cttgacgtagccgcccgcttCgtctcctttctgcaccacga	8	17	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:57637672C>A	uc001snp.2	-	12	1213	c.1018G>T	c.(1018-1020)GAA>TAA	p.E340*	STAC3_uc009zpl.2_Missense_Mutation_p.R57L|STAC3_uc001snq.2_Nonsense_Mutation_p.E301*|STAC3_uc010srm.1_Nonsense_Mutation_p.E154*	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	340	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						CCGCCCGCTTCGTCTCCTTTC	0.562											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.12818e-05	0.001984	8.33022e-05	5	16										A	57637672	C	A	57637672	4	1	99	1	0	0	0	0	0	1	0	0	15240	893	31	3	80	3	STAC3	12	57637672	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4016441	57637672	76214223	278	30419										
NAV3	89795	broad.mit.edu	37	chr12	78515755	78515755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggcaggtggcaaatctgcctCtgcacctaatactgagggtg	13	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:78515755C>G	uc001syp.2	+	16	3958	c.3785C>G	c.(3784-3786)TCT>TGT	p.S1262C	NAV3_uc001syo.2_Missense_Mutation_p.S1262C|NAV3_uc010sub.1_Missense_Mutation_p.S762C|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1262	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAATCTGCCTCTGCACCTAAT	0.463										HNSCC(70;0.22)			0	0	0	0.004007	0	12	35										G	78515755	C	G	78515755	3	3	99	1	0	0	0	0	1	0	0	0	10185	913	32	1	3847	1	NAV3	12	78515755	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	20878083	78515755	55336140	279	30420										
PPFIA2	8499	broad.mit.edu	37	chr12	81741427	81741427	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcgatgaagctgtaacagagGcagtaatggaggtacctggg	16	6	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:81741427G>T	uc001szo.1	-	18	2278	c.2117C>A	c.(2116-2118)GCC>GAC	p.A706D	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_Intron	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	632										ovary(3)|lung(2)|pancreas(1)	6						TGTAACAGAGGCAGTAATGGA	0.532													1	0	7.07328e-35	0.01441	7.81707e-35	64	103										T	81741427	G	T	81741427	3	4	99	1	0	0	0	0	1	0	0	0	12310	1203	42	4	1716	4	PPFIA2	12	81741427	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3225672	81741427	52110468	280	30421										
STAB2	55576	broad.mit.edu	37	chr12	104044296	104044296	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaagcttatgcctggccactGagtaagctgggacccttcac	10	12	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:104044296G>A	uc001tjw.2	+	11	1383	c.1197G>A	c.(1195-1197)CTG>CTA	p.L399L		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	399	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCTGGCCACTGAGTAAGCTGG	0.448													0	0	0	0.00499	0	14	37										A	104044296	G	A	104044296	2	1	99	1	0	0	0	0	0	0	0	1	15237	1277	45	1		1	STAB2	12	104044296	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	22302869	104044296	29807599	281	30422										
OAS3	4940	broad.mit.edu	37	chr12	113388756	113388756	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agagctggacggatgttagcCtgctgcctgccttcgatgct	13	11	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:113388756C>G	uc001tug.2	+	7	1720	c.1633C>G	c.(1633-1635)CTG>GTG	p.L545V		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	545	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GGATGTTAGCCTGCTGCCTGC	0.617													0	0	0	0.008871	0	16	34										G	113388756	C	G	113388756	3	3	99	1	0	0	0	0	1	0	0	0	10801	680	24	4	1659	4	OAS3	12	113388756	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9344460	113388756	20463139	282	30423										
TBX3	6926	broad.mit.edu	37	chr12	115118866	115118866	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaatttataacgacagtcatCagcagctataatgtccatca	5	9	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:115118866C>G	uc001tvt.1	-	2	1439	c.475G>C	c.(475-477)GAT>CAT	p.D159H	TBX3_uc001tvu.1_Missense_Mutation_p.D159H|TBX3_uc010syw.1_Missense_Mutation_p.D159H	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	159	T-box; first part.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CGACAGTCATCAGCAGCTATA	0.438													0	0	0	0.004289	0	32	92										G	115118866	C	G	115118866	3	3	99	1	0	0	0	0	1	0	0	0	15656	826	29	1	1784	1	TBX3	12	115118866	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1730110	115118866	18733029	283	30424										
DNAH10	196385	broad.mit.edu	37	chr12	124401030	124401030	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcctttaatgaccctgacttCctcaagcagctagagatgtc	7	12	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:124401030C>T	uc001uft.3	+	62	10420	c.10395C>T	c.(10393-10395)TTC>TTT	p.F3465F		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3465	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACCCTGACTTCCTCAAGCAGC	0.478													0	0	0	0.01441	0	53	78										T	124401030	C	T	124401030	2	4	99	1	0	0	0	0	0	0	0	1	4598	854	30	1		1	DNAH10	12	124401030	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	9282164	124401030	9450865	284	30425										
PIBF1	10464	broad.mit.edu	37	chr13	73409499	73409499	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctagggaaatgtatgaacgaGaaaacaggtaaaaaaaaaaa	9	3	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:73409499G>C	uc001vjc.2	+	9	1521	c.1216G>C	c.(1216-1218)GAA>CAA	p.E406Q	PIBF1_uc001vja.1_Missense_Mutation_p.E406Q|PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Missense_Mutation_p.E406Q|PIBF1_uc010aep.2_5'UTR	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	406						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GTATGAACGAGAAAACAGGTA	0.269													0	0	0	0.003954	0	18	48										C	73409499	G	C	73409499	3	2	99	1	0	0	0	0	1	0	0	0	11879	943	33	1	1246	1	PIBF1	13	73409499	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		73409499	41760379	285	30426										
MYCBP2	23077	broad.mit.edu	37	chr13	77714227	77714227	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgactttcactatgcctatCtgctcactctgaagggaagg	9	10	4	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:77714227C>T	uc001vkf.2	-	52	7450	c.7359G>A	c.(7357-7359)CAG>CAA	p.Q2453Q	MYCBP2_uc010aev.2_Silent_p.Q1857Q	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTATGCCTATCTGCTCACTCT	0.423													0	0	0	0.008291	0	10	36										T	77714227	C	T	77714227	2	4	99	1	0	0	0	0	0	0	0	1	10018	912	32	1		1	MYCBP2	13	77714227	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4304728	77714227	37455651	286	30427										
FARP1	10160	broad.mit.edu	37	chr13	99047670	99047670	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggcgcccacggaggaagagGaggaggtcgttaaggatagg	19	7	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:99047670G>A	uc001vnj.2	+	13	1690	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	FARP1_uc001vnh.2_Missense_Mutation_p.E452K	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	452	Poly-Glu.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GGAGGAAGAGGAGGAGGTCGT	0.687													0	0	0	0.00499	0	15	22										A	99047670	G	A	99047670	3	1	99	1	0	0	0	0	1	0	0	0	5676	1175	41	1	1623	1	FARP1	13	99047670	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	21333443	99047670	16122208	287	30428										
ITGBL1	9358	broad.mit.edu	37	chr13	102359164	102359164	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agaggatggtttggaaagctCtgccaacatccgcggaagtg	14	8	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:102359164C>G	uc001vpb.2	+	9	1410	c.1191C>G	c.(1189-1191)CTC>CTG	p.L397L	ITGBL1_uc010agb.2_Silent_p.L348L|ITGBL1_uc001vpc.3_Silent_p.L256L	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	397	VIII.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGGAAAGCTCTGCCAACATC	0.498													0	0	0	0.008291	0	7	54										G	102359164	C	G	102359164	2	3	99	1	0	0	0	0	0	0	0	1	7902	900	32	1		1	ITGBL1	13	102359164	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3311494	102359164	12810714	288	30429										
COL4A2	1284	broad.mit.edu	37	chr13	111117923	111117923	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caccaggcttcctgggccctCctggccccgcagggacccca	11	20	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:111117923C>T	uc001vqx.2	+	25	2237	c.1948C>T	c.(1948-1950)CCT>TCT	p.P650S		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	650	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCTGGGCCCTCCTGGCCCCGC	0.587													0	0	0	0.010729	0	9	18										T	111117923	C	T	111117923	3	4	99	1	0	0	0	0	1	0	0	0	3690	855	30	1	2042	1	COL4A2	13	111117923	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	8758759	111117923	4051955	289	30430										
PARP2	10038	broad.mit.edu	37	chr14	20824776	20824776	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctatggcatggttccaggatGagtaactgggtgggaatctt	14	6	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:20824776G>A	uc001vxc.2	+	13	1324	c.1296G>A	c.(1294-1296)ATG>ATA	p.M432I	PARP2_uc001vxd.2_Missense_Mutation_p.M419I|PARP2_uc001vxb.1_Missense_Mutation_p.M432I|PARP2_uc010tle.1_Missense_Mutation_p.M182I	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	432	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		GTTCCAGGATGAGTAACTGGG	0.468								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.01441	0	57	185										A	20824776	G	A	20824776	3	1	99	1	0	0	0	0	1	0	0	0	11461	1290	45	1	1346	1	PARP2	14	20824776	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		20824776	86524764	290	30431										
TEP1	7011	broad.mit.edu	37	chr14	20848600	20848600	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aacactgcaacgtcagcctcGgggagcttttgttcctcttt	9	12	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:20848600G>A	uc001vxe.2	-	34	4837	c.4797C>T	c.(4795-4797)CCC>CCT	p.P1599P	TEP1_uc010ahk.2_Silent_p.P942P|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.P1491P|TEP1_uc010tlh.1_5'UTR	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1599					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CGTCAGCCTCGGGGAGCTTTT	0.587													0	0	0	0.001984	0	5	36										A	20848600	G	A	20848600	2	1	99	1	0	0	0	0	0	0	0	1	15756	1103	39	2		2	TEP1	14	20848600	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	23824	20848600	86500940	291	30432										
ACIN1	22985	broad.mit.edu	37	chr14	23533582	23533582	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acctttagtgattcagtggtGatactgatggaaggtttctt	11	5	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:23533582G>A	uc001wit.3	-	11	2926	c.2598C>T	c.(2596-2598)ATC>ATT	p.I866I	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Silent_p.I108I|ACIN1_uc001wiq.3_Silent_p.I108I|ACIN1_uc001wir.3_Silent_p.I139I|ACIN1_uc001wis.3_Silent_p.I547I|ACIN1_uc010akg.2_Silent_p.I865I	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	866					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ATTCAGTGGTGATACTGATGG	0.587													0	0	0	0.01441	0	60	113										A	23533582	G	A	23533582	2	1	99	1	0	0	0	0	0	0	0	1	142	1280	45	1		1	ACIN1	14	23533582	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2684982	23533582	83815958	292	30433										
LTB4R2	56413	broad.mit.edu	37	chr14	24780721	24780722	+	Frame_Shift_Ins	INS	-	-	C													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcttcagttctagcgtcaaINScccggtgctctacgtcttca							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:24780721_24780722insC	uc001woq.1	+	1	2561_2562	c.944_945insC	c.(943-945)AACfs	p.N315fs	CIDEB_uc001woo.2_5'Flank|CIDEB_uc001wop.2_5'Flank|LTB4R2_uc010alo.2_Frame_Shift_Ins_p.N284fs|LTB4R2_uc001wor.2_Frame_Shift_Ins_p.N284fs|LTB4R_uc001wos.2_5'UTR|LTB4R_uc010alp.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	315	Helical; Name=7; (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		TCTAGCGTCAACCCGGTGCTCT	0.698																		21	54	---	---								C	24780722	-	C	24780721	7	5	99	1	0	1	1	0	0	0	0	0	9072	43	2	0	853	0	LTB4R2	14	24780721	Frame_Shift_Ins	INS	-	TCGA-G2-A3IE-01A-11D-A20D-08	1247139	24780721	82568819	293	30434										
HECTD1	25831	broad.mit.edu	37	chr14	31611068	31611068	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaatttgagattttacctttCatcatcttcattttcactaa	2	8	5	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:31611068C>T	uc001wrc.1	-	18	3358	c.2869G>A	c.(2869-2871)GAA>AAA	p.E957K	HECTD1_uc001wrd.1_Missense_Mutation_p.E472K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	957					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTTTACCTTTCATCATCTTCA	0.294													0	0	0	0.001168	0	6	10										T	31611068	C	T	31611068	3	4	99	1	0	0	0	0	1	0	0	0	7039	835	29	1	5067	1	HECTD1	14	31611068	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	6830347	31611068	75738472	294	30435										
RALGAPA1	253959	broad.mit.edu	37	chr14	36128344	36128344	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctaagaatatccgacctacCgtgcaggaccagagggctca	10	12	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:36128344C>A	uc001wti.2	-	27	4260	c.3869G>T	c.(3868-3870)CGA>CTA	p.R1290L	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.R1290L|RALGAPA1_uc010tpv.1_Missense_Mutation_p.R1303L|RALGAPA1_uc010tpw.1_Missense_Mutation_p.R1337L	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1290					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TCCGACCTACCGTGCAGGACC	0.368													1	0	1.60099e-16	0.004878	1.72662e-16	27	21										A	36128344	C	A	36128344	3	1	99	1	0	0	0	0	1	0	0	0	13013	666	23	4	2450	4	RALGAPA1	14	36128344	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4517276	36128344	71221196	295	30436										
POLE2	5427	broad.mit.edu	37	chr14	50118022	50118022	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caaattgctgctaggaaaacGgacgcagtttctgcacattt	9	9	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:50118022G>A	uc001wwu.2	-	16	1299	c.1285C>T	c.(1285-1287)CGT>TGT	p.R429C	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Missense_Mutation_p.R143C|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Missense_Mutation_p.R144C	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	429					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTAGGAAAACGGACGCAGTTT	0.328													0	0	0	0.001168	0	3	37										A	50118022	G	A	50118022	3	1	99	1	0	0	0	0	1	0	0	0	12197	1116	39	2	314	2	POLE2	14	50118022	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	13989678	50118022	57231518	296	30437										
SOS2	6655	broad.mit.edu	37	chr14	50585132	50585132	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtgcgaaagctcccgtttgTaagtctttggtggcagtttt	13	7	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:50585132T>C	uc001wxs.3	-	23	4027	c.3929A>G	c.(3928-3930)TAC>TGC	p.Y1310C	SOS2_uc010ans.2_Missense_Mutation_p.Y145C|SOS2_uc010tql.1_Missense_Mutation_p.Y1277C|C14orf138_uc001wxn.1_5'Flank|C14orf138_uc001wxo.1_5'Flank|C14orf138_uc001wxp.1_5'Flank|C14orf138_uc001wxq.1_5'Flank	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1310					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					CTCCCGTTTGTAAGTCTTTGG	0.483													0	0	0	0.00874	0	35	37										C	50585132	T	C	50585132	3	2	99	1	0	0	0	0	1	0	0	0	14937	1638	57	5	73	5	SOS2	14	50585132	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	467110	50585132	56764408	297	30438										
VASH1	22846	broad.mit.edu	37	chr14	77242469	77242469	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgctgctggcacgtgctcaaGaaggtgaagctgggccagag	16	10	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:77242469G>A	uc001xst.2	+	5	1695	c.765G>A	c.(763-765)AAG>AAA	p.K255K		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	255					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		ACGTGCTCAAGAAGGTGAAGC	0.677													0	0	0	0.00308	0	5	13										A	77242469	G	A	77242469	2	1	99	1	0	0	0	0	0	0	0	1	17122	933	33	1		1	VASH1	14	77242469	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	26657337	77242469	30107071	298	30439										
GALC	2581	broad.mit.edu	37	chr14	88459326	88459326	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccgctcaccccgccgccgctGaccgcgccgatgccgtcgaa	11	21	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:88459326G>A	uc001xvt.2	-	1	582	c.183C>T	c.(181-183)GTC>GTT	p.V61V	GALC_uc010tvx.1_Intron|GALC_uc010tvy.1_Silent_p.V61V|GALC_uc010tvz.1_5'Flank|GALC_uc001xvu.1_Silent_p.V61V	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	61					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						CGCCGCCGCTGACCGCGCCGA	0.776													0	0	0	0.004482	0	5	3										A	88459326	G	A	88459326	2	1	99	1	0	0	0	0	0	0	0	1	6201	1277	45	1		1	GALC	14	88459326	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	11216857	88459326	18890214	299	30440										
TRIP11	9321	broad.mit.edu	37	chr14	92471337	92471337	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gctctgaacttttgtttcttGaaaaatatcagagttatctg	7	6	4	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:92471337G>A	uc001xzy.2	-	11	3771	c.2983C>T	c.(2983-2985)CAA>TAA	p.Q995*	TRIP11_uc010auf.1_Nonsense_Mutation_p.Q731*	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	995	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTTGTTTCTTGAAAAATATCA	0.323			T	PDGFRB	AML								0	0	0	0.000602	0	5	24										A	92471337	G	A	92471337	4	1	99	1	0	0	0	0	0	1	0	0	16552	1299	45	1	3000	1	TRIP11	14	92471337	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4012011	92471337	14878203	300	30441										
AK7	122481	broad.mit.edu	37	chr14	96924468	96924468	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggaaggagaagaagaagtcGaagaggaagaggaggaggag	21	1	0	5	rs149622950	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:96924468G>C	uc001yfn.2	+	12	1320	c.1276G>C	c.(1276-1278)GAA>CAA	p.E426Q		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	426	Adenylate kinase.|Potential.|Poly-Glu.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		agaagaagtcgaagaggaaga	0.393													0	0	0	0.006122	0	18	20										C	96924468	G	C	96924468	3	2	99	1	0	0	0	0	1	0	0	0	444	1059	37	1	1322	1	AK7	14	96924468	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4453131	96924468	10425072	301	30442										
AHNAK2	113146	broad.mit.edu	37	chr14	105407021	105407021	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caaggaggccacaagctcttCtgggccctgagacacacagg	12	13	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:105407021C>G	uc010axc.1	-	7	14887	c.14767G>C	c.(14767-14769)GAA>CAA	p.E4923Q	AHNAK2_uc001ypx.2_Missense_Mutation_p.E4823Q	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4923						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACAAGCTCTTCTGGGCCCTGA	0.587													0	0	0	0.008291	0	11	57										G	105407021	C	G	105407021	3	3	99	1	0	0	0	0	1	0	0	0	415	922	32	1	2624	1	AHNAK2	14	105407021	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	8482553	105407021	1942519	302	30443										
CYFIP1	23191	broad.mit.edu	37	chr15	22925788	22925788	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgttccagcccaggatggcGgcccaggtgactctggagga	15	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:22925788G>T	uc001yus.2	+	2	110	c.6G>T	c.(4-6)GCG>GCT	p.A2A	CYFIP1_uc001yut.2_Silent_p.A2A|CYFIP1_uc010aya.1_Silent_p.A60A	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	2					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CCAGGATGGCGGCCCAGGTGA	0.647													1	0	0.000151284	0.001855	0.000154161	10	9										T	22925788	G	T	22925788	2	4	99	1	0	0	0	0	0	0	0	1	4137	1103	39	4		4	CYFIP1	15	22925788	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		22925788	79605604	303	30444										
MAP1A	4130	broad.mit.edu	37	chr15	43819552	43819552	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagagcccacaccctatcctGatgagagaagctttcagtat	9	11	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43819552G>A	uc001zrt.2	+	4	6348	c.5881G>A	c.(5881-5883)GAT>AAT	p.D1961N		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1961						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	ACCCTATCCTGATGAGAGAAG	0.562													0	0	0	0.008361	0	23	68										A	43819552	G	A	43819552	3	1	99	1	0	0	0	0	1	0	0	0	9227	1290	45	1	5883	1	MAP1A	15	43819552	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	20893764	43819552	58711840	304	30445										
MAP1A	4130	broad.mit.edu	37	chr15	43820098	43820098	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccacattatggccagaaactGaggcacatgttagccctccc	8	14	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43820098G>T	uc001zrt.2	+	4	6894	c.6427G>T	c.(6427-6429)GAG>TAG	p.E2143*		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2143						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCCAGAAACTGAGGCACATGT	0.592													1	0	2.00529e-23	0.00333	2.18908e-23	19	87										T	43820098	G	T	43820098	4	4	99	1	0	0	0	0	0	1	0	0	9227	1291	45	3	6429	3	MAP1A	15	43820098	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	546	43820098	58711294	305	30446										
MAP1A	4130	broad.mit.edu	37	chr15	43821274	43821274	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggcagccctcgactcagatGaagatggagacttcctacct	10	12	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43821274G>A	uc001zrt.2	+	4	8070	c.7603G>A	c.(7603-7605)GAA>AAA	p.E2535K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2535						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CGACTCAGATGAAGATGGAGA	0.587													0	0	0	0.01441	0	37	160										A	43821274	G	A	43821274	3	1	99	1	0	0	0	0	1	0	0	0	9227	1291	45	1	7605	1	MAP1A	15	43821274	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1176	43821274	58710118	306	30447										
TRIM69	140691	broad.mit.edu	37	chr15	45047506	45047506	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgatctgctttcaatgcaagGatgctcggttgtctgtgggg	14	7	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:45047506G>C	uc001zuf.2	+	3	1310	c.415G>C	c.(415-417)GAT>CAT	p.D139H	TRIM69_uc001zui.1_Intron|TRIM69_uc010bdy.1_Intron|TRIM69_uc001zug.1_Missense_Mutation_p.D139H|TRIM69_uc001zuh.1_Intron	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	139	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		TCAATGCAAGGATGCTCGGTT	0.507													0	0	0	0.004289	0	30	36										C	45047506	G	C	45047506	3	2	99	1	0	0	0	0	1	0	0	0	16539	1174	41	1	421	1	TRIM69	15	45047506	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1226232	45047506	57483886	307	30448										
SEMA6D	80031	broad.mit.edu	37	chr15	48056959	48056959	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctgccgttccacccattgccGatgagccctggttcacaaag	9	15	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:48056959G>A	uc010bek.2	+	12	1582	c.1222G>A	c.(1222-1224)GAT>AAT	p.D408N	SEMA6D_uc001zvw.2_Missense_Mutation_p.D408N|SEMA6D_uc001zvx.1_Missense_Mutation_p.D408N|SEMA6D_uc001zvy.2_Missense_Mutation_p.D408N|SEMA6D_uc001zvz.2_Missense_Mutation_p.D408N|SEMA6D_uc001zwa.2_Missense_Mutation_p.D408N|SEMA6D_uc001zwb.2_Missense_Mutation_p.D408N|SEMA6D_uc001zwc.2_Missense_Mutation_p.D408N	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	408	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACCCATTGCCGATGAGCCCTG	0.502													0	0	0	0.000602	0	4	52										A	48056959	G	A	48056959	3	1	99	1	0	0	0	0	1	0	0	0	14042	1058	37	1	1264	1	SEMA6D	15	48056959	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3009453	48056959	54474433	308	30449										
SLC12A1	6557	broad.mit.edu	37	chr15	48548007	48548007	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aatttcctcctttatccacaGatgtgaactggggctcctcc	7	13	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:48548007G>A	uc001zwn.3	+	16	2159	c.1943_splice	c.e16-1	p.D648_splice	SLC12A1_uc010uew.1_Splice_Site_p.D454_splice|SLC12A1_uc010bem.2_Splice_Site_p.D648_splice|SLC12A1_uc001zwq.3_Splice_Site_p.D419_splice|SLC12A1_uc001zwr.3_Splice_Site_p.D375_splice	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2						potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TTTATCCACAGATGTGAACTG	0.423													0	0	0	0.009096	0	3	10										A	48548007	G	A	48548007	5	1	99	1	0	0	0	0	0	0	1	0	14382	956	33	1	2100	1	SLC12A1	15	48548007	Splice_Site	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	491048	48548007	53983385	309	30450										
PRTG	283659	broad.mit.edu	37	chr15	55912272	55912272	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tatctcatcgttggactcatGagaaaaccgcccagaatccc	7	13	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:55912272G>T	uc002adg.2	-	20	3439	c.3391C>A	c.(3391-3393)CAT>AAT	p.H1131N		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	1131					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTGGACTCATGAGAAAACCGC	0.483													1	0	1.36615e-20	0.013726	1.48832e-20	30	44										T	55912272	G	T	55912272	3	4	99	1	0	0	0	0	1	0	0	0	12638	1290	45	3	65	3	PRTG	15	55912272	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7364265	55912272	46619120	310	30451										
ALDH1A2	8854	broad.mit.edu	37	chr15	58357784	58357784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcgacggcaggaggtgcagcGacgccatgagggcggcgggg	22	10	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:58357784G>A	uc002aex.2	-	1	123	c.65C>T	c.(64-66)TCG>TTG	p.S22L	ALDH1A2_uc002aey.2_Missense_Mutation_p.S22L|ALDH1A2_uc010ugv.1_5'UTR|ALDH1A2_uc010ugw.1_Intron	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	22					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GAGGTGCAGCGACGCCATGAG	0.662													0	0	0	0.001855	0	10	17										A	58357784	G	A	58357784	3	1	99	1	0	0	0	0	1	0	0	0	491	1059	37	1	1543	1	ALDH1A2	15	58357784	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2445512	58357784	44173608	311	30452										
HERC1	8925	broad.mit.edu	37	chr15	63920999	63920999	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggttctcgaacatggttggTatggcctaagccgagctggg	15	8	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:63920999T>C	uc002amp.2	-	70	13130	c.12982A>G	c.(12982-12984)ACC>GCC	p.T4328A		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4328	RCC1 14.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ACATGGTTGGTATGGCCTAAG	0.468													0	0	0	0.01441	0	47	99										C	63920999	T	C	63920999	3	2	99	1	0	0	0	0	1	0	0	0	7057	1638	57	5	1639	5	HERC1	15	63920999	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	5563215	63920999	38610393	312	30453										
ANKDD1A	348094	broad.mit.edu	37	chr15	65209672	65209672	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agcacgaggctgctgtggacGaggaggatgcggtaggggcc	20	8	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:65209672G>A	uc002aoa.2	+	3	255	c.226G>A	c.(226-228)GAG>AAG	p.E76K	ANKDD1A_uc002anx.1_Missense_Mutation_p.E76K|ANKDD1A_uc002any.2_5'UTR|ANKDD1A_uc002anz.2_Intron|ANKDD1A_uc002aob.2_Missense_Mutation_p.E46K	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	76	ANK 2.				signal transduction					ovary(1)	1						TGCTGTGGACGAGGAGGATGC	0.607													0	0	0	0.009096	0	2	3										A	65209672	G	A	65209672	3	1	99	1	0	0	0	0	1	0	0	0	624	1059	37	1	236	1	ANKDD1A	15	65209672	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1288673	65209672	37321720	313	30454										
DIS3L	115752	broad.mit.edu	37	chr15	66625127	66625127	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	taaagatggtttagtcatctCatgtggcccagatagctgtt	10	7	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:66625127C>T	uc010ujm.1	+	16	2750	c.2735C>T	c.(2734-2736)TCA>TTA	p.S912L	DIS3L_uc002app.2_Missense_Mutation_p.S829L|DIS3L_uc010bho.2_Missense_Mutation_p.S778L	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	912					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						TTAGTCATCTCATGTGGCCCA	0.363													0	0	0	0.011902	0	37	50										T	66625127	C	T	66625127	3	4	99	1	0	0	0	0	1	0	0	0	4536	838	29	1	2797	1	DIS3L	15	66625127	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1415455	66625127	35906265	314	30455										
SPESP1	246777	broad.mit.edu	37	chr15	69238236	69238236	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cacacggaaagtaccccattCtggtcgatcaaaccaaacaa	6	13	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:69238236C>G	uc002arn.1	+	2	491	c.363C>G	c.(361-363)TTC>TTG	p.F121L	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	121					multicellular organismal development	acrosomal vesicle					0						GTACCCCATTCTGGTCGATCA	0.428													0	0	0	0.007413	0	16	18										G	69238236	C	G	69238236	3	3	99	1	0	0	0	0	1	0	0	0	15039	912	32	1	369	1	SPESP1	15	69238236	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2613109	69238236	33293156	315	30456										
NPTN	27020	broad.mit.edu	37	chr15	73866075	73866080	+	In_Frame_Del	DEL	AGTGGC	AGTGGC	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccaactgacttgcaatacatAgtggcatcctgcccttcatt							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:73866075_73866080delAGTGGC	uc002avs.2	-	5	960_965	c.763_768delGCCACT	c.(763-768)GCCACTdel	p.AT255del	NPTN_uc010bjc.2_In_Frame_Del_p.AT255del|NPTN_uc002avt.2_In_Frame_Del_p.AT139del|NPTN_uc002avr.2_In_Frame_Del_p.AT139del|NPTN_uc010ula.1_In_Frame_Del_p.AT50del	NM_012428	NP_036560	Q9Y639	NPTN_HUMAN	neuroplastin isoform b precursor	255_256	Ig-like 3.|Extracellular (Potential).				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding				0						TGCAATACATAGTGGCATCCTGCCCT	0.549																		26	96	---	---								-	73866080	AGTGGC	-	73866075	7	5	99	1	0	1	0	1	0	0	0	0	10601	407	15	0	444	0	NPTN	15	73866075	In_Frame_Del	DEL	AGTGGC	TCGA-G2-A3IE-01A-11D-A20D-08	4627839	73866075	28665317	316	30457										
CYP1A2	1544	broad.mit.edu	37	chr15	75042806	75042806	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggacttcttccccatccttCgctacctgcctaaccctgcc	5	19	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75042806C>G	uc002ayr.1	+	2	791	c.727C>G	c.(727-729)CGC>GGC	p.R243G		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	243					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CCCCATCCTTCGCTACCTGCC	0.557													0	0	0	0.01441	0	43	65										G	75042806	C	G	75042806	3	3	99	1	0	0	0	0	1	0	0	0	4150	884	31	1	729	1	CYP1A2	15	75042806	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1176731	75042806	27488586	317	30458										
SCAMP5	192683	broad.mit.edu	37	chr15	75308956	75308956	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aacagcgtcacgctggccgtGaacctggtgggctgtctcgc	14	13	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75308956G>A	uc002azk.1	+	4	321	c.159G>A	c.(157-159)GTG>GTA	p.V53V	SCAMP5_uc002azl.1_Silent_p.V53V|SCAMP5_uc002azm.1_Silent_p.V53V|SCAMP5_uc002azn.1_Silent_p.V53V|SCAMP5_uc010uly.1_Intron	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	53	Helical; (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						CGCTGGCCGTGAACCTGGTGG	0.617													0	0	0	0.007291	0	22	64										A	75308956	G	A	75308956	2	1	99	1	0	0	0	0	0	0	0	1	13874	1277	45	1		1	SCAMP5	15	75308956	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	266150	75308956	27222436	318	30459										
SNX33	257364	broad.mit.edu	37	chr15	75942838	75942838	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagcagcccaagaatgacctCttccagatgctggacacact	9	13	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75942838C>G	uc002bau.2	+	1	1491	c.1395C>G	c.(1393-1395)CTC>CTG	p.L465L	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_Intron	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	465	BAR.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						AGAATGACCTCTTCCAGATGC	0.542													0	0	0	0.01441	0	71	118										G	75942838	C	G	75942838	2	3	99	1	0	0	0	0	0	0	0	1	14903	900	32	1		1	SNX33	15	75942838	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	633882	75942838	26588554	319	30460										
SCAPER	49855	broad.mit.edu	37	chr15	76797229	76797229	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	attcttaaaactgtgttcacAtttgtggctgggactactgc	9	8	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:76797229A>G	uc002bby.2	-	23	2984	c.2925T>C	c.(2923-2925)AAT>AAC	p.N975N	SCAPER_uc010bkr.2_Silent_p.N283N|SCAPER_uc002bbx.2_Silent_p.N729N|SCAPER_uc002bbz.1_Silent_p.N846N	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	974						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						CTGTGTTCACATTTGTGGCTG	0.383													0	0	0	0.006122	0	13	23										G	76797229	A	G	76797229	2	3	99	1	0	0	0	0	0	0	0	1	13878	214	8	5		5	SCAPER	15	76797229	Silent	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	854391	76797229	25734163	320	30461										
MORF4L1	10933	broad.mit.edu	37	chr15	79184578	79184578	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaacattcatgaacagagttGaagttaaagtaaagattcct	7	5	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:79184578G>A	uc002bel.2	+	9	768	c.580G>A	c.(580-582)GAA>AAA	p.E194K	MORF4L1_uc010blj.1_Missense_Mutation_p.E128K|MORF4L1_uc002bem.2_Missense_Mutation_p.E155K|MORF4L1_uc010une.1_Missense_Mutation_p.E67K	NM_206839	NP_996670	Q9UBU8	MO4L1_HUMAN	MORF-related gene 15 isoform 2	194	Sufficient for interaction with PHF12.|Sufficient for interaction with SIN3A.|Interaction with RB1-1.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding				0						GAACAGAGTTGAAGTTAAAGT	0.388													0	0	0	0.004656	0	18	28										A	79184578	G	A	79184578	3	1	99	1	0	0	0	0	1	0	0	0	9706	1291	45	1	614	1	MORF4L1	15	79184578	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2387349	79184578	23346814	321	30462										
ZFAND6	54469	broad.mit.edu	37	chr15	80423554	80423554	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acacagcacagcagccatctGaagagcaaagcaagtctctt	8	12	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:80423554G>A	uc002bfe.1	+	6	708	c.397G>A	c.(397-399)GAA>AAA	p.E133K	ZFAND6_uc002bff.1_Missense_Mutation_p.E133K|ZFAND6_uc002bfg.1_Missense_Mutation_p.E121K|ZFAND6_uc002bfh.1_Missense_Mutation_p.E133K|ZFAND6_uc002bfi.1_Missense_Mutation_p.E133K	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	133							DNA binding|zinc ion binding				0						GCAGCCATCTGAAGAGCAAAG	0.388													0	0	0	0.008871	0	17	93										A	80423554	G	A	80423554	3	1	99	1	0	0	0	0	1	0	0	0	17628	1291	45	1	411	1	ZFAND6	15	80423554	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1238976	80423554	22107838	322	30463										
AKAP13	11214	broad.mit.edu	37	chr15	86284652	86284652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtgctgcccagaaacagcttGagagggaacaggagcagctg	15	9	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:86284652G>C	uc002blv.1	+	35	8154	c.7984G>C	c.(7984-7986)GAG>CAG	p.E2662Q	AKAP13_uc002blu.1_Missense_Mutation_p.E2666Q|AKAP13_uc002blw.1_Missense_Mutation_p.E1127Q|AKAP13_uc002blx.1_Missense_Mutation_p.E907Q	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2662	Interaction with ESR1.|Potential.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GAAACAGCTTGAGAGGGAACA	0.627													0	0	0	0.010504	0	14	24										C	86284652	G	C	86284652	3	2	99	1	0	0	0	0	1	0	0	0	449	1291	45	1	8188	1	AKAP13	15	86284652	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	5861098	86284652	16246740	323	30464										
FANCI	55215	broad.mit.edu	37	chr15	89834929	89834929	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gacccaaggagataagatctCtctacaagaaccactggtga	9	10	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:89834929C>G	uc010bnp.1	+	20	2066	c.1976C>G	c.(1975-1977)TCT>TGT	p.S659C	FANCI_uc002bnm.1_Missense_Mutation_p.S659C|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.S480C|FANCI_uc002bnq.1_Missense_Mutation_p.S72C	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	659					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GATAAGATCTCTCTACAAGAA	0.378								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.003271	0	27	55										G	89834929	C	G	89834929	3	3	99	1	0	0	0	0	1	0	0	0	5669	913	32	1	2050	1	FANCI	15	89834929	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	3550277	89834929	12696463	324	30465										
FANCI	55215	broad.mit.edu	37	chr15	89850893	89850893	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctgtgttattctttcatttCttacgtacaggtaagagatt	7	7	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:89850893C>G	uc010bnp.1	+	34	3731	c.3641C>G	c.(3640-3642)TCT>TGT	p.S1214C	FANCI_uc002bnm.1_Missense_Mutation_p.S1154C|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.S974C|FANCI_uc002bnq.1_Missense_Mutation_p.S627C	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1214					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCTTTCATTTCTTACGTACAG	0.443								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007291	0	23	73										G	89850893	C	G	89850893	3	3	99	1	0	0	0	0	1	0	0	0	5669	913	32	1	3771	1	FANCI	15	89850893	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	15964	89850893	12680499	325	30466										
IGF1R	3480	broad.mit.edu	37	chr15	99459287	99459287	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctctgcccaacggcaacctGagttactacattgtgcgctg	9	13	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:99459287G>C	uc002bul.2	+	9	1973	c.1923G>C	c.(1921-1923)CTG>CTC	p.L641L	IGF1R_uc010urq.1_Silent_p.L641L|IGF1R_uc010bon.2_Silent_p.L641L|IGF1R_uc010urr.1_Silent_p.L91L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	641	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ACGGCAACCTGAGTTACTACA	0.557													0	0	0	0.01441	0	45	51										C	99459287	G	C	99459287	2	2	99	1	0	0	0	0	0	0	0	1	7571	1277	45	1		1	IGF1R	15	99459287	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	9608394	99459287	3072105	326	30467										
LINS1	55180	broad.mit.edu	37	chr15	101109548	101109548	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttttcttttgcaaacggcaGatggcatcttgtagttcctg	9	8	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:101109548G>C	uc002bwe.2	-	8	2460	c.2169C>G	c.(2167-2169)ATC>ATG	p.I723M	LINS1_uc002bwd.2_Missense_Mutation_p.I310M|LINS1_uc002bwf.2_Missense_Mutation_p.I723M|LINS1_uc002bwg.2_Missense_Mutation_p.I723M|LINS1_uc002bwh.2_Missense_Mutation_p.I723M	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	723											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			GCAAACGGCAGATGGCATCTT	0.353													0	0	0	0.010771	0	37	70										C	101109548	G	C	101109548	3	2	99	1	0	0	0	0	1	0	0	0	8818	932	33	1	108	1	LINS1	15	101109548	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1650261	101109548	1421844	327	30468										
TFAP4	7023	broad.mit.edu	37	chr16	4310208	4310208	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggaggcggtgctggcacgatCaccgtggggtggtgggtggg	23	7	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:4310208C>T	uc010uxg.1	-	6	959	c.705G>A	c.(703-705)GTG>GTA	p.V235V		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	235	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CTGGCACGATCACCGTGGGGT	0.617													0	0	0	0.00245	0	11	20										T	4310208	C	T	4310208	2	4	99	1	0	0	0	0	0	0	0	1	15789	813	29	1		1	TFAP4	16	4310208	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		4310208	86044545	328	30469										
MGRN1	23295	broad.mit.edu	37	chr16	4721438	4721438	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggagatctatggcattgagaAcaagaacaaccaggagacca	11	8	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:4721438A>T	uc002cwz.2	+	9	909	c.773A>T	c.(772-774)AAC>ATC	p.N258I	MGRN1_uc002cxa.2_Missense_Mutation_p.N258I|MGRN1_uc010btx.2_Missense_Mutation_p.N259I|MGRN1_uc010btw.2_Missense_Mutation_p.N259I|MGRN1_uc002cxb.2_Missense_Mutation_p.N258I|MGRN1_uc010uxo.1_Missense_Mutation_p.N258I|MGRN1_uc010uxp.1_Missense_Mutation_p.N258I|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	258					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GGCATTGAGAACAAGAACAAC	0.587													0	0	0	0.012319	0	17	35										T	4721438	A	T	4721438	3	4	99	1	0	0	0	0	1	0	0	0	9559	43	2	5	810	5	MGRN1	16	4721438	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	411230	4721438	85633315	329	30470										
GRIN2A	2903	broad.mit.edu	37	chr16	9858060	9858060	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctatagtgtagatcttgtctCtaggggagcttgatttggtt	12	5	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:9858060C>G	uc002czo.3	-	13	3889	c.3341G>C	c.(3340-3342)AGA>ACA	p.R1114T	GRIN2A_uc010uym.1_Missense_Mutation_p.R1114T|GRIN2A_uc010uyn.1_Missense_Mutation_p.R957T|GRIN2A_uc002czr.3_Missense_Mutation_p.R1114T	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1114	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATCTTGTCTCTAGGGGAGCT	0.483													0	0	0	0.007835	0	31	158										G	9858060	C	G	9858060	3	3	99	1	0	0	0	0	1	0	0	0	6779	913	32	1	1057	1	GRIN2A	16	9858060	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5136622	9858060	80496693	330	30471										
GRIN2A	2903	broad.mit.edu	37	chr16	9916214	9916214	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatagttattccgaatgtttCtctccgtgcttccattaggc	8	10	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:9916214C>G	uc002czo.3	-	10	2623	c.2075G>C	c.(2074-2076)AGA>ACA	p.R692T	GRIN2A_uc010uym.1_Missense_Mutation_p.R692T|GRIN2A_uc010uyn.1_Missense_Mutation_p.R535T|GRIN2A_uc002czr.3_Missense_Mutation_p.R692T	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	692	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGAATGTTTCTCTCCGTGCT	0.388													0	0	0	0.003271	0	27	101										G	9916214	C	G	9916214	3	3	99	1	0	0	0	0	1	0	0	0	6779	913	32	1	2335	1	GRIN2A	16	9916214	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	58154	9916214	80438539	331	30472										
CIITA	4261	broad.mit.edu	37	chr16	10996617	10996617	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccatgggctctggcaaatctCtgaggctggaacaggggtct	14	10	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:10996617C>G	uc002dai.3	+	8	864	c.731C>G	c.(730-732)TCT>TGT	p.S244C	CIITA_uc002daj.3_Missense_Mutation_p.S245C|CIITA_uc002dak.3_Missense_Mutation_p.S195C|CIITA_uc002dag.2_Missense_Mutation_p.S244C|CIITA_uc002dah.2_Missense_Mutation_p.S196C|CIITA_uc010bup.1_Missense_Mutation_p.S244C	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	244					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TGGCAAATCTCTGAGGCTGGA	0.592			T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								0	0	0	0.008361	0	25	46										G	10996617	C	G	10996617	3	3	99	1	0	0	0	0	1	0	0	0	3428	913	32	1	761	1	CIITA	16	10996617	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1080403	10996617	79358136	332	30473										
ABCC6	368	broad.mit.edu	37	chr16	16297332	16297332	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggctgagggtccccaggagGaaggtagaatggaacacctg	16	8	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:16297332G>A	uc002den.3	-	8	970	c.933C>T	c.(931-933)TTC>TTT	p.F311F	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.F323F	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	311	ABC transmembrane type-1 1.|Helical; Name=6; (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCCCCAGGAGGAAGGTAGAAT	0.592													0	0	0	0.004007	0	13	49										A	16297332	G	A	16297332	2	1	99	1	0	0	0	0	0	0	0	1	57	1165	41	1		1	ABCC6	16	16297332	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	5300715	16297332	74057421	333	30474										
ACSM3	6296	broad.mit.edu	37	chr16	20787320	20787320	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagatcgggtaattctgattCtgcccagggtcccagagtgg	14	9	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:20787320C>T	uc002dhr.2	+	3	566	c.379C>T	c.(379-381)CTG>TTG	p.L127L	ACSM3_uc002dhq.2_Silent_p.L127L|ACSM3_uc010vba.1_Silent_p.L119L	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	127					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						AATTCTGATTCTGCCCAGGGT	0.463													0	0	0	0.004656	0	19	79										T	20787320	C	T	20787320	2	4	99	1	0	0	0	0	0	0	0	1	185	912	32	1		1	ACSM3	16	20787320	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4489988	20787320	69567433	334	30475										
TNRC6A	27327	broad.mit.edu	37	chr16	24802435	24802435	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagtgggggaattgcaaagaGgagaaggctgcatggaatga	17	4	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:24802435G>C	uc002dmm.2	+	6	2586	c.2472G>C	c.(2470-2472)GAG>GAC	p.E824D	TNRC6A_uc010bxs.2_Missense_Mutation_p.E571D|TNRC6A_uc010vcc.1_Missense_Mutation_p.E571D|TNRC6A_uc002dmn.2_Missense_Mutation_p.E571D|TNRC6A_uc002dmo.2_Missense_Mutation_p.E571D	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	824	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ATTGCAAAGAGGAGAAGGCTG	0.507													0	0	0	0.003163	0	15	20										C	24802435	G	C	24802435	3	2	99	1	0	0	0	0	1	0	0	0	16337	991	35	4	2494	4	TNRC6A	16	24802435	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	4015115	24802435	65552318	335	30476										
IL21R	50615	broad.mit.edu	37	chr16	27456588	27456588	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctggagcctgaagacccatcCattgtggaggtgaggccagg	15	10	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:27456588C>T	uc002doq.1	+	7	1009	c.776C>T	c.(775-777)CCA>CTA	p.P259L	IL21R_uc002dor.1_Missense_Mutation_p.P259L|IL21R_uc002dos.1_Missense_Mutation_p.P259L	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	259	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						AAGACCCATCCATTGTGGAGG	0.552			T	BCL6	NHL								0	0	0	0.00499	0	12	13										T	27456588	C	T	27456588	3	4	99	1	0	0	0	0	1	0	0	0	7671	594	21	2	798	2	IL21R	16	27456588	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2654153	27456588	62898165	336	30477										
KCTD13	253980	broad.mit.edu	37	chr16	29918391	29918391	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtctcgtagatgaggatgttCagggtctcctcgaagatccg	13	9	3	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:29918391C>T	uc002duv.2	-	6	983	c.792G>A	c.(790-792)CTG>CTA	p.L264L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ASPHD1_uc002duu.3_Intron|ASPHD1_uc010bzi.2_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	264					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						TGAGGATGTTCAGGGTCTCCT	0.672													0	0	0	0.01441	0	85	33										T	29918391	C	T	29918391	2	4	99	1	0	0	0	0	0	0	0	1	8100	813	29	1		1	KCTD13	16	29918391	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2461803	29918391	60436362	337	30478										
MAPK3	5595	broad.mit.edu	37	chr16	30134479	30134479	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gacccccgggccgaccccctCggttctacggggctccccgc	12	21	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30134479C>G	uc002dws.2	-	1	152	c.52G>C	c.(52-54)GAG>CAG	p.E18Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_5'Flank|MAPK3_uc002dwv.3_Missense_Mutation_p.E18Q|MAPK3_uc002dwt.2_Missense_Mutation_p.E18Q|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	18					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CCGACCCCCTCGGTTCTACGG	0.408													0	0	0	0.00278	0	20	7										G	30134479	C	G	30134479	3	3	99	1	0	0	0	0	1	0	0	0	9279	893	31	1	1176	1	MAPK3	16	30134479	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	216088	30134479	60220274	338	30479										
ZNF689	115509	broad.mit.edu	37	chr16	30616102	30616102	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtgactgaccaggcgagagGaggaggagaagcgccgctcg	19	9	0	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30616102G>T	uc002dyx.2	-	3	1306	c.986C>A	c.(985-987)TCC>TAC	p.S329Y	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	329	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CAGGCGAGAGGAGGAGGAGAA	0.701													1	0	1.58986e-06	0.008291	1.65149e-06	6	49										T	30616102	G	T	30616102	3	4	99	1	0	0	0	0	1	0	0	0	18091	1174	41	3	520	3	ZNF689	16	30616102	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	481623	30616102	59738651	339	30480										
SRCAP	10847	broad.mit.edu	37	chr16	30736314	30736314	+	Frame_Shift_Del	DEL	C	C	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cactgacattgcgctctggtCcccccagccctccctccact							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30736314delC	uc002dze.1	+	25	5954	c.5569delC	c.(5569-5571)CCCfs	p.P1857fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Del_p.P1652fs|SRCAP_uc010bzz.1_Frame_Shift_Del_p.P1427fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1857	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCGCTCTGGTCCCCCCAGCCC	0.612																		7	972	---	---								-	30736314	C	-	30736314	7	5	99	1	0	1	0	1	0	0	0	0	15134	855	30	0	5659	0	SRCAP	16	30736314	Frame_Shift_Del	DEL	C	TCGA-G2-A3IE-01A-11D-A20D-08	120212	30736314	59618439	340	30481										
RNF40	9810	broad.mit.edu	37	chr16	30780218	30780218	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agggatcgaagggagagcaaGaagatcgcggatgaggatgc	18	5	0	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30780218G>C	uc002dzq.2	+	15	2280	c.2157G>C	c.(2155-2157)AAG>AAC	p.K719N	RNF40_uc010caa.2_Missense_Mutation_p.K719N|RNF40_uc010cab.2_Missense_Mutation_p.K619N|RNF40_uc010vfa.1_Missense_Mutation_p.K51N|RNF40_uc002dzr.2_Missense_Mutation_p.K719N|RNF40_uc010vfb.1_Missense_Mutation_p.K411N|RNF40_uc010vfc.1_Missense_Mutation_p.K51N	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	719	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GGGAGAGCAAGAAGATCGCGG	0.592													0	0	0	0.01441	0	122	60										C	30780218	G	C	30780218	3	2	99	1	0	0	0	0	1	0	0	0	13493	933	33	1	2211	1	RNF40	16	30780218	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	43904	30780218	59574535	341	30482										
TRIM72	493829	broad.mit.edu	37	chr16	31226097	31226097	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctcctgcaccaggagctgtCctgcccgctgtgcctgcagc	11	18	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:31226097C>G	uc002ebn.1	+	2	267	c.38C>G	c.(37-39)TCC>TGC	p.S13C		NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	13					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						CAGGAGCTGTCCTGCCCGCTG	0.756													0	0	0	0.013537	0	8	15										G	31226097	C	G	31226097	3	3	99	1	0	0	0	0	1	0	0	0	16542	855	30	1	40	1	TRIM72	16	31226097	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	445879	31226097	59128656	342	30483										
GPR56	9289	broad.mit.edu	37	chr16	57693505	57693505	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgcctttcctggatgggcctCgaggggtacaacctctaccg	12	13	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693505C>G	uc002emb.2	+	12	1777	c.1485C>G	c.(1483-1485)CTC>CTG	p.L495L	GPR56_uc002elz.1_Silent_p.L325L|GPR56_uc002ema.1_Silent_p.L320L|GPR56_uc002emc.2_Silent_p.L489L|GPR56_uc002emf.2_Silent_p.L489L|GPR56_uc010vhs.1_Silent_p.L495L|GPR56_uc002emd.2_Silent_p.L489L|GPR56_uc002eme.2_Silent_p.L489L|GPR56_uc010vht.1_Silent_p.L494L|GPR56_uc002emg.3_Silent_p.L489L|GPR56_uc010vhu.1_Silent_p.L314L	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	495	Helical; Name=3; (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						GGATGGGCCTCGAGGGGTACA	0.622													0	0	0	0.00623	0	27	75										G	57693505	C	G	57693505	2	3	99	1	0	0	0	0	0	0	0	1	6700	871	31	1		1	GPR56	16	57693505	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	26467408	57693505	32661248	343	30484			3	133		3	3	67	C		4.570063e-07
GPR56	9289	broad.mit.edu	37	chr16	57693541	57693541	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	taccgactcgtggtggaggtCtttggcacctatgtccctgg	13	11	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693541C>G	uc002emb.2	+	12	1813	c.1521C>G	c.(1519-1521)GTC>GTG	p.V507V	GPR56_uc002elz.1_Silent_p.V337V|GPR56_uc002ema.1_Silent_p.V332V|GPR56_uc002emc.2_Silent_p.V501V|GPR56_uc002emf.2_Silent_p.V501V|GPR56_uc010vhs.1_Silent_p.V507V|GPR56_uc002emd.2_Silent_p.V501V|GPR56_uc002eme.2_Silent_p.V501V|GPR56_uc010vht.1_Silent_p.V506V|GPR56_uc002emg.3_Silent_p.V501V|GPR56_uc010vhu.1_Silent_p.V326V	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	507	Cytoplasmic (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						TGGTGGAGGTCTTTGGCACCT	0.627													0	0	0	0.006999	0	19	87										G	57693541	C	G	57693541	2	3	99	1	0	0	0	0	0	0	0	1	6700	900	32	1		1	GPR56	16	57693541	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	36	57693541	32661212	344	30485			3	133		3	3	67	C		4.570063e-07
GPR56	9289	broad.mit.edu	37	chr16	57693571	57693571	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tatgtccctggctacctactCaagctgagcgccatgggctg	11	13	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693571C>G	uc002emb.2	+	12	1843	c.1551C>G	c.(1549-1551)CTC>CTG	p.L517L	GPR56_uc002elz.1_Silent_p.L347L|GPR56_uc002ema.1_Silent_p.L342L|GPR56_uc002emc.2_Silent_p.L511L|GPR56_uc002emf.2_Silent_p.L511L|GPR56_uc010vhs.1_Silent_p.L517L|GPR56_uc002emd.2_Silent_p.L511L|GPR56_uc002eme.2_Silent_p.L511L|GPR56_uc010vht.1_Silent_p.L516L|GPR56_uc002emg.3_Silent_p.L511L|GPR56_uc010vhu.1_Silent_p.L336L	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	517	Cytoplasmic (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						GCTACCTACTCAAGCTGAGCG	0.622													0	0	0	0.00632	0	14	83										G	57693571	C	G	57693571	2	3	99	1	0	0	0	0	0	0	0	1	6700	813	29	1		1	GPR56	16	57693571	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	30	57693571	32661182	345	30486			3	133		3	3	67	C		4.570063e-07
CDH1	999	broad.mit.edu	37	chr16	68844139	68844139	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catccaacgggaatgcagttGaggatccaatggagattttg	12	7	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:68844139G>C	uc002ewg.1	+	6	851	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.E243Q	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	243	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.E243*(2)|p.?(2)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GAATGCAGTTGAGGATCCAAT	0.493			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.01441	0	63	89										C	68844139	G	C	68844139	3	2	99	1	0	0	0	0	1	0	0	0	3095	1291	45	1	749	1	CDH1	16	68844139	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	11150568	68844139	21510614	346	30487										
CDH1	999	broad.mit.edu	37	chr16	68845691	68845691	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gccaagatcctgagctccctGacaaaaatatgttcaccatt	6	12	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:68845691G>A	uc002ewg.1	+	7	1061	c.937G>A	c.(937-939)GAC>AAC	p.D313N	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.D313N	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	313	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGAGCTCCCTGACAAAAATAT	0.542			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.004656	0	23	37										A	68845691	G	A	68845691	3	1	99	1	0	0	0	0	1	0	0	0	3095	1290	45	1	963	1	CDH1	16	68845691	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1552	68845691	21509062	347	30488										
GLG1	2734	broad.mit.edu	37	chr16	74493622	74493622	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atcttgagcaggttgaccttGaggcactcctccacctgacc	9	14	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:74493622G>C	uc002fcy.3	-	23	3152	c.3102C>G	c.(3100-3102)CTC>CTG	p.L1034L	GLG1_uc002fcx.2_Silent_p.L1034L|GLG1_uc002fcw.3_Silent_p.L1023L|GLG1_uc002fcz.3_Silent_p.L451L	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	1034	Extracellular (Potential).|Cys-rich GLG1 15.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						GGTTGACCTTGAGGCACTCCT	0.438													0	0	0	0.004007	0	12	22										C	74493622	G	C	74493622	2	2	99	1	0	0	0	0	0	0	0	1	6436	1277	45	1		1	GLG1	16	74493622	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	5647931	74493622	15861131	348	30489										
JPH3	57338	broad.mit.edu	37	chr16	87677915	87677915	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcgccagggctacggcgtccGgcagagcgtcccgtatggca	16	14	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:87677915G>A	uc002fkd.2	+	2	688	c.434G>A	c.(433-435)CGG>CAG	p.R145Q	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	145	MORN 6.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TACGGCGTCCGGCAGAGCGTC	0.677													0	0	0	0.01441	0	39	38										A	87677915	G	A	87677915	3	1	99	1	0	0	0	0	1	0	0	0	7962	1116	39	2	440	2	JPH3	16	87677915	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	13184293	87677915	2676838	349	30490										
ZNF232	7775	broad.mit.edu	37	chr17	5009120	5009120	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agacgttctccccttcaattCaatgggaaggctcttttctg	8	11	5	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009120C>G	uc002gas.2	-	5	2007	c.1253G>C	c.(1252-1254)TGA>TCA	p.*418S	ZNF232_uc002gar.1_Nonstop_Mutation_p.*436S|ZNF232_uc002gat.2_Nonstop_Mutation_p.*445S	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	418					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CCCTTCAATTCAATGGGAAGG	0.403													0	0	0	0.010771	0	36	22										G	5009120	C	G	5009120	4	3	99	1	0	0	0	0	0	0	0	0	17782	837	29	1	4	1	ZNF232	17	5009120	Nonstop_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		5009120	76186090	350	30491			4	134		4	4	515	C		6.964944e-08
ZNF232	7775	broad.mit.edu	37	chr17	5009220	5009220	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttacatataaaaggtttctCtccactgtgaattctccgat	5	9	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009220C>G	uc002gas.2	-	5	1907	c.1153G>C	c.(1153-1155)GAG>CAG	p.E385Q	ZNF232_uc002gar.1_Missense_Mutation_p.E403Q|ZNF232_uc002gat.2_Missense_Mutation_p.E412Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	385					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AAAGGTTTCTCTCCACTGTGA	0.443													0	0	0	0.009535	0	25	20										G	5009220	C	G	5009220	3	3	99	1	0	0	0	0	1	0	0	0	17782	922	32	1	104	1	ZNF232	17	5009220	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	100	5009220	76185990	351	30492			4	134		4	4	515	C		6.964944e-08
ZNF232	7775	broad.mit.edu	37	chr17	5009367	5009367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctgaaggccttcccacattCattacattcgaagggtttct	7	11	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009367C>G	uc002gas.2	-	5	1760	c.1006G>C	c.(1006-1008)GAA>CAA	p.E336Q	ZNF232_uc002gar.1_Missense_Mutation_p.E354Q|ZNF232_uc002gat.2_Missense_Mutation_p.E363Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	336	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTCCCACATTCATTACATTCG	0.463													0	0	0	0.010504	0	19	26										G	5009367	C	G	5009367	3	3	99	1	0	0	0	0	1	0	0	0	17782	835	29	1	251	1	ZNF232	17	5009367	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	147	5009367	76185843	352	30493			4	134		4	4	515	C		6.964944e-08
ZNF232	7775	broad.mit.edu	37	chr17	5009634	5009634	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggggaccacctcagtctctCcgctttgggatttctctgct	10	13	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009634C>T	uc002gas.2	-	5	1493	c.739G>A	c.(739-741)GAG>AAG	p.E247K	ZNF232_uc002gar.1_Missense_Mutation_p.E265K|ZNF232_uc002gat.2_Missense_Mutation_p.E274K	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	247					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CTCAGTCTCTCCGCTTTGGGA	0.478													0	0	0	0.013114	0	38	28										T	5009634	C	T	5009634	3	4	99	1	0	0	0	0	1	0	0	0	17782	864	30	1	518	1	ZNF232	17	5009634	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	267	5009634	76185576	353	30494			4	134		4	4	515	C		6.964944e-08
RPAIN	84268	broad.mit.edu	37	chr17	5324736	5324736	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcaagaggtgatggaagaaGagtggaatgctttgcagtca	14	4	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5324736G>A	uc002gbq.2	+	2	772	c.202G>A	c.(202-204)GAG>AAG	p.E68K	NUP88_uc002gbo.1_5'Flank|NUP88_uc010vsx.1_5'Flank|NUP88_uc010cle.1_5'Flank|NUP88_uc010vsy.1_5'Flank|RPAIN_uc010vsz.1_Missense_Mutation_p.E68K|RPAIN_uc002gbp.1_Missense_Mutation_p.R121K|RPAIN_uc010vta.1_Missense_Mutation_p.E68K|RPAIN_uc010vtb.1_Missense_Mutation_p.E68K|RPAIN_uc002gbs.2_Missense_Mutation_p.R121K|RPAIN_uc002gbt.2_Missense_Mutation_p.E68K|RPAIN_uc002gbu.2_Missense_Mutation_p.R121K|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Missense_Mutation_p.E68K	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	68					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						GATGGAAGAAGAGTGGAATGC	0.532													0	0	0	0.007835	0	31	21										A	5324736	G	A	5324736	3	1	99	1	0	0	0	0	1	0	0	0	13540	943	33	1	208	1	RPAIN	17	5324736	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	315102	5324736	75870474	354	30495										
TP53	7157	broad.mit.edu	37	chr17	7577099	7577099	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cttcctctgtgcgccggtctCtcccaggacaggcacaaaca	9	16	2	0	rs121912660		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:7577099C>T	uc002gim.2	-	8	1033	c.839G>A	c.(838-840)AGA>AAA	p.R280K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148K|TP53_uc010cng.1_Missense_Mutation_p.R148K|TP53_uc002gii.1_Missense_Mutation_p.R148K|TP53_uc010cnh.1_Missense_Mutation_p.R280K|TP53_uc010cni.1_Missense_Mutation_p.R280K|TP53_uc002gij.2_Missense_Mutation_p.R280K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.001855	0	12	9										T	7577099	C	T	7577099	3	4	99	1	0	0	0	0	1	0	0	0	16378	913	32	1	447	1	TP53	17	7577099	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2252363	7577099	73618111	355	30496										
DNAH2	146754	broad.mit.edu	37	chr17	7643069	7643069	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggtatgtgactgtcagtatCacttcgcccgctgggaagat	12	9	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:7643069C>T	uc002giu.1	+	8	1203	c.1189C>T	c.(1189-1191)CAC>TAC	p.H397Y	DNAH2_uc002git.2_Missense_Mutation_p.H479Y|DNAH2_uc010vuk.1_Missense_Mutation_p.H397Y	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	397	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGTCAGTATCACTTCGCCCG	0.488													0	0	0	0.008291	0	10	5										T	7643069	C	T	7643069	3	4	99	1	0	0	0	0	1	0	0	0	4602	826	29	1	1219	1	DNAH2	17	7643069	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	65970	7643069	73552141	356	30497										
KRBA2	124751	broad.mit.edu	37	chr17	8272483	8272483	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggagaccggaagtcccttgtGaggtgctgggttctgaagct	16	8	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:8272483G>C	uc002glf.1	-	2	1454	c.1448C>G	c.(1447-1449)TCA>TGA	p.S483*	KRBA2_uc002glg.1_Nonsense_Mutation_p.S400*	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	483					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						AGTCCCTTGTGAGGTGCTGGG	0.527													0	0	0	0.010504	0	17	15										C	8272483	G	C	8272483	4	2	99	1	0	0	0	0	0	1	0	0	8440	1294	45	1	34	1	KRBA2	17	8272483	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	629414	8272483	72922727	357	30498										
MYH10	4628	broad.mit.edu	37	chr17	8422065	8422065	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gctctgaaaaatatcttgctCtgtccaattctgtacaagtt	6	9	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:8422065C>G	uc002gll.2	-	19	2391	c.2295G>C	c.(2293-2295)CAG>CAC	p.Q765H	MYH10_uc002glm.2_Missense_Mutation_p.Q796H|MYH10_uc010cnx.2_Missense_Mutation_p.Q774H	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	765	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						ATATCTTGCTCTGTCCAATTC	0.358													0	0	0	0.009535	0	22	21										G	8422065	C	G	8422065	3	3	99	1	0	0	0	0	1	0	0	0	10030	912	32	1	3727	1	MYH10	17	8422065	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	149582	8422065	72773145	358	30499										
MYH3	4621	broad.mit.edu	37	chr17	10543493	10543493	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggaggggcttgatcttgaaGaagagtttcatccagggcca	14	7	2	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:10543493G>T	uc002gmq.1	-	21	2579	c.2502C>A	c.(2500-2502)TTC>TTA	p.F834L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	834					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGATCTTGAAGAAGAGTTTCA	0.458													1	0	2.85442e-18	0.010818	3.0971e-18	29	31										T	10543493	G	T	10543493	3	4	99	1	0	0	0	0	1	0	0	0	10036	933	33	3	3400	3	MYH3	17	10543493	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2121428	10543493	70651717	359	30500										
MPRIP	23164	broad.mit.edu	37	chr17	17083324	17083324	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttatataccgcagatataatGaaatctaaaagcaaccctga	5	8	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:17083324G>A	uc002gqu.1	+	22	3023	c.2967G>A	c.(2965-2967)ATG>ATA	p.M989I	MPRIP_uc002gqv.1_Missense_Mutation_p.M989I|MPRIP_uc002gqw.1_Missense_Mutation_p.M744I|MPRIP_uc002gqx.1_Missense_Mutation_p.M1218I|MPRIP_uc002gqy.1_Missense_Mutation_p.M1218I|MPRIP_uc010cpl.1_Missense_Mutation_p.M175I|MPRIP_uc010cpm.1_Missense_Mutation_p.M175I	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	989						cytoplasm|cytoskeleton	actin binding				0						CAGATATAATGAAATCTAAAA	0.443													0	0	0	0.010504	0	18	13										A	17083324	G	A	17083324	3	1	99	1	0	0	0	0	1	0	0	0	9743	1290	45	1	3053	1	MPRIP	17	17083324	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	6539831	17083324	64111886	360	30501										
PROCA1	147011	broad.mit.edu	37	chr17	27030629	27030629	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttttctcttgtttaccttccTggcttgtgagggctttgccc	9	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:27030629T>C	uc002hcb.3	-	5	1167	c.964A>G	c.(964-966)AGG>GGG	p.R322G	PROCA1_uc010crv.2_Missense_Mutation_p.R248G|PROCA1_uc002hca.1_Missense_Mutation_p.R320G	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	348					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					TTTACCTTCCTGGCTTGTGAG	0.532													0	0	0	0.01441	0	58	101										C	27030629	T	C	27030629	3	2	99	1	0	0	0	0	1	0	0	0	12546	1579	55	5	56	5	PROCA1	17	27030629	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	9947305	27030629	54164581	361	30502										
ATAD5	79915	broad.mit.edu	37	chr17	29196272	29196272	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaataatttttcagatttctCgggtggcatagactttaaag	9	5	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:29196272C>T	uc002hfs.1	+	13	3666	c.3320C>T	c.(3319-3321)TCG>TTG	p.S1107L	ATAD5_uc002hft.1_Missense_Mutation_p.S1004L	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1107					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCAGATTTCTCGGGTGGCATA	0.393													0	0	0	0.005443	0	21	39										T	29196272	C	T	29196272	3	4	99	1	0	0	0	0	1	0	0	0	1076	893	31	1	3370	1	ATAD5	17	29196272	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2165643	29196272	51998938	362	30503										
LRRC37B	114659	broad.mit.edu	37	chr17	30348940	30348940	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctgagcaagttggactttctCaattccatctagagcccaaa	7	11	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:30348940C>G	uc002hgu.2	+	1	786	c.775C>G	c.(775-777)CAA>GAA	p.Q259E	LRRC37B_uc010wbx.1_Missense_Mutation_p.Q177E|LRRC37B_uc010csu.2_Missense_Mutation_p.Q259E	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	259	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TGGACTTTCTCAATTCCATCT	0.527													0	0	0	0.01441	0	57	118										G	30348940	C	G	30348940	3	3	99	1	0	0	0	0	1	0	0	0	8994	827	29	1	777	1	LRRC37B	17	30348940	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1152668	30348940	50846270	363	30504										
CCL1	6346	broad.mit.edu	37	chr17	32688819	32688819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cttacattaagccctcattgGagcagatggagctggtattt	10	8	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:32688819G>A	uc002hid.1	-	2	245	c.173C>T	c.(172-174)TCC>TTC	p.S58F		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	58					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GCCCTCATTGGAGCAGATGGA	0.483											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	82	182										A	32688819	G	A	32688819	3	1	99	1	0	0	0	0	1	0	0	0	2882	1174	41	1	125	1	CCL1	17	32688819	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2339879	32688819	48506391	364	30505										
MYO19	80179	broad.mit.edu	37	chr17	34856680	34856680	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcccacctacctgcctggatGagcatgacggcccgccactg	11	17	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:34856680G>A	uc010wcy.1	-	24	3359	c.2367C>T	c.(2365-2367)CTC>CTT	p.L789L	MYO19_uc002hmw.2_Silent_p.L589L|MYO19_uc010cuu.2_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	789	IQ 2.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCCTGGATGAGCATGACGG	0.647													0	0	0	0.009096	0	3	22										A	34856680	G	A	34856680	2	1	99	1	0	0	0	0	0	0	0	1	10067	1277	45	1		1	MYO19	17	34856680	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2167861	34856680	46338530	365	30506										
MRM1	79922	broad.mit.edu	37	chr17	34958561	34958561	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggcccagacggcagaaactgGacacaatgtgccgctaccag	12	13	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:34958561G>A	uc002hne.2	+	1	537	c.322G>A	c.(322-324)GAC>AAC	p.D108N	MRM1_uc002hnf.2_5'UTR	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	108					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GCAGAAACTGGACACAATGTG	0.697													0	0	0	0.005443	0	22	29										A	34958561	G	A	34958561	3	1	99	1	0	0	0	0	1	0	0	0	9771	1174	41	1	324	1	MRM1	17	34958561	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	101881	34958561	46236649	366	30507										
TADA2A	6871	broad.mit.edu	37	chr17	35804849	35804849	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagacattgattttgttgaaGatgactcggacattttacat	9	5	0	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:35804849G>A	uc002hnt.2	+	8	740	c.583G>A	c.(583-585)GAT>AAT	p.D195N	TADA2A_uc002hnu.1_Missense_Mutation_p.D195N|TADA2A_uc002hnv.2_Missense_Mutation_p.D195N|TADA2A_uc010wdd.1_Missense_Mutation_p.D195N|TADA2A_uc002hnw.2_Missense_Mutation_p.D94N|TADA2A_uc010cvb.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	195					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TTTTGTTGAAGATGACTCGGA	0.264													0	0	0	0.01441	0	83	170										A	35804849	G	A	35804849	3	1	99	1	0	0	0	0	1	0	0	0	15507	942	33	1	609	1	TADA2A	17	35804849	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	846288	35804849	45390361	367	30508										
SMARCE1	6605	broad.mit.edu	37	chr17	38787930	38787930	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcctctatttgaagaagttCagcttctagttttcgctgca	7	9	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:38787930C>G	uc002hux.2	-	9	854	c.730G>C	c.(730-732)GAA>CAA	p.E244Q	SMARCE1_uc010wff.1_Missense_Mutation_p.E209Q|SMARCE1_uc010wfg.1_Missense_Mutation_p.E174Q|SMARCE1_uc002huy.2_Missense_Mutation_p.E209Q|SMARCE1_uc010wfh.1_Missense_Mutation_p.E174Q|SMARCE1_uc010wfi.1_Missense_Mutation_p.E226Q	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	244	Potential.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				TGAAGAAGTTCAGCTTCTAGT	0.353													0	0	0	0.00333	0	20	38										G	38787930	C	G	38787930	3	3	99	1	0	0	0	0	1	0	0	0	14780	835	29	1	517	1	SMARCE1	17	38787930	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2983081	38787930	42407280	368	30509										
KCNH4	23415	broad.mit.edu	37	chr17	40317544	40317544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaaggcagccccatactcagGatagagcctcaggacctcag	11	13	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40317544G>A	uc002hzb.2	-	11	2341	c.2008C>T	c.(2008-2010)CCT>TCT	p.P670S		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	670	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCATACTCAGGATAGAGCCTC	0.607													0	0	0	0.008291	0	11	41										A	40317544	G	A	40317544	3	1	99	1	0	0	0	0	1	0	0	0	8034	1174	41	1	1069	1	KCNH4	17	40317544	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1529614	40317544	40877666	369	30510										
KCNH4	23415	broad.mit.edu	37	chr17	40317638	40317638	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcagcactggtctttagcacGaagtttgggtctgctcccaa	10	11	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40317638G>A	uc002hzb.2	-	11	2247	c.1914C>T	c.(1912-1914)TTC>TTT	p.F638F		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	638	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCTTTAGCACGAAGTTTGGGT	0.592													0	0	0	0.008361	0	23	38										A	40317638	G	A	40317638	2	1	99	1	0	0	0	0	0	0	0	1	8034	1049	37	1		1	KCNH4	17	40317638	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	94	40317638	40877572	370	30511										
KCNH4	23415	broad.mit.edu	37	chr17	40321612	40321612	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagtccttgaggtccttcatGcggctgtggtagagcgagcg	15	9	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40321612G>A	uc002hzb.2	-	9	1806	c.1473C>T	c.(1471-1473)CGC>CGT	p.R491R		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	491	Helical; Name=Segment S6; (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGTCCTTCATGCGGCTGTGGT	0.637													0	0	0	0.005443	0	24	57										A	40321612	G	A	40321612	2	1	99	1	0	0	0	0	0	0	0	1	8034	1306	46	2		2	KCNH4	17	40321612	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3974	40321612	40873598	371	30512										
TUBG2	27175	broad.mit.edu	37	chr17	40818450	40818450	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaagtctccctacctgccctCggcccaccgggtcagcgggc	12	18	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40818450C>T	uc010wgr.1	+	10	1362	c.1106C>T	c.(1105-1107)TCG>TTG	p.S369L	TUBG2_uc002iaq.2_Missense_Mutation_p.S211L|TUBG2_uc002iar.2_Missense_Mutation_p.S216L|TUBG2_uc002ias.2_Missense_Mutation_p.S211L|TUBG2_uc002iap.2_Missense_Mutation_p.S216L	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	369					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TACCTGCCCTCGGCCCACCGG	0.607													0	0	0	0.01441	0	39	66										T	40818450	C	T	40818450	3	4	99	1	0	0	0	0	1	0	0	0	16762	893	31	1	1144	1	TUBG2	17	40818450	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	496838	40818450	40376760	372	30513										
MYCBPAP	84073	broad.mit.edu	37	chr17	48599420	48599420	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaagccagcttgctggatcaGaggcagtaatccacaggaca	12	10	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:48599420G>A	uc010wmr.1	+	10	1526	c.1364G>A	c.(1363-1365)AGA>AAA	p.R455K	MYCBPAP_uc002iqx.2_Missense_Mutation_p.R455K|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	418					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGCTGGATCAGAGGCAGTAAT	0.562													0	0	0	0.00623	0	33	23										A	48599420	G	A	48599420	3	1	99	1	0	0	0	0	1	0	0	0	10019	942	33	1	1402	1	MYCBPAP	17	48599420	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7780970	48599420	32595790	373	30514										
KIAA0195	9772	broad.mit.edu	37	chr17	73488566	73488566	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttcccccagacccagcctggGatggagagcgacccctacga	11	16	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:73488566G>C	uc002jnz.3	+	15	1883	c.1608G>C	c.(1606-1608)GGG>GGC	p.G536G	KIAA0195_uc010wsa.1_Silent_p.G546G|KIAA0195_uc010wsb.1_Silent_p.G176G	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	536					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCAGCCTGGGATGGAGAGCG	0.632													0	0	0	0.00308	0	5	37										C	73488566	G	C	73488566	2	2	99	1	0	0	0	0	0	0	0	1	8160	1161	41	1		1	KIAA0195	17	73488566	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	24889146	73488566	7706644	374	30515										
SEC14L1	6397	broad.mit.edu	37	chr17	75196652	75196652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagatcatgtgtcagtctttGacgtggagaaagcagcatca	12	7	4	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:75196652G>C	uc002jto.2	+	9	1173	c.906G>C	c.(904-906)TTG>TTC	p.L302F	SEC14L1_uc010dhc.2_Missense_Mutation_p.L302F|SEC14L1_uc010wth.1_Missense_Mutation_p.L302F|SEC14L1_uc002jtm.2_Missense_Mutation_p.L302F|SEC14L1_uc010wti.1_Missense_Mutation_p.L268F	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	302					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						GTCAGTCTTTGACGTGGAGAA	0.458													0	0	0	0.01441	0	58	37										C	75196652	G	C	75196652	3	2	99	1	0	0	0	0	1	0	0	0	13981	1281	45	1	932	1	SEC14L1	17	75196652	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1708086	75196652	5998558	375	30516										
B4GALT6	9331	broad.mit.edu	37	chr18	29218639	29218639	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ataaaacgcaaattccagccGctgcttctggagcattggaa	9	10	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:29218639G>A	uc002kwz.3	-	5	853	c.556C>T	c.(556-558)CGG>TGG	p.R186W	B4GALT6_uc010dma.2_Missense_Mutation_p.R147W|B4GALT6_uc010dmb.2_Intron	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	186	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			AATTCCAGCCGCTGCTTCTGG	0.358													0	0	0	0.000602	0	3	86										A	29218639	G	A	29218639	3	1	99	1	0	0	0	0	1	0	0	0	1275	1086	38	2	612	2	B4GALT6	18	29218639	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08		29218639	48858609	376	30517										
RIT2	6014	broad.mit.edu	37	chr18	40323592	40323592	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttccctcactaagccatgaaAagcatcatcaatacagaatc	4	12	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:40323592A>T	uc002lav.2	-	5	693	c.520T>A	c.(520-522)TTT>ATT	p.F174I	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	174					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						AAGCCATGAAAAGCATCATCA	0.428													0	0	0	0.010504	0	20	33										T	40323592	A	T	40323592	3	4	99	1	0	0	0	0	1	0	0	0	13387	14	1	5	137	5	RIT2	18	40323592	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	11104953	40323592	37753656	377	30518										
ZBTB7C	201501	broad.mit.edu	37	chr18	45567023	45567023	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcctcctcctcctcttcgtcCtcctcatcatcatcatcttc	1	20	6	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:45567023C>G	uc002lda.2	-	1	472	c.456G>C	c.(454-456)GAG>GAC	p.E152D	ZBTB7C_uc002ldb.2_Missense_Mutation_p.E152D|ZBTB7C_uc010dnu.2_Missense_Mutation_p.E161D|ZBTB7C_uc010dnv.2_Missense_Mutation_p.E174D|ZBTB7C_uc010dnw.2_Missense_Mutation_p.E152D|ZBTB7C_uc010dnx.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dny.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dnz.1_Missense_Mutation_p.E174D|ZBTB7C_uc010dob.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doc.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dod.1_Missense_Mutation_p.E174D|ZBTB7C_uc010doe.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dof.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dog.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doh.1_Missense_Mutation_p.E161D|ZBTB7C_uc010doi.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doj.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dok.1_Missense_Mutation_p.E201D|ZBTB7C_uc010dol.1_Missense_Mutation_p.E161D|ZBTB7C_uc010doa.1_Missense_Mutation_p.E174D|ZBTB7C_uc010don.1_Missense_Mutation_p.E160D|ZBTB7C_uc010doo.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dop.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doq.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dor.1_Missense_Mutation_p.E174D|ZBTB7C_uc010dos.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dot.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dou.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dom.1_Missense_Mutation_p.E161D	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	152	Glu-rich.|Asp-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						cctcttcgtcctcctcatcat	0.284													0	0	0	0.000602	0	5	17										G	45567023	C	G	45567023	3	3	99	1	0	0	0	0	1	0	0	0	17552	680	24	4	1411	4	ZBTB7C	18	45567023	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5243431	45567023	32510225	378	30519										
ALPK2	115701	broad.mit.edu	37	chr18	56203518	56203518	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aagggctgactcagcatcctCtggactgtgagccaatgctg	12	11	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:56203518C>G	uc002lhj.3	-	5	4115	c.3901G>C	c.(3901-3903)GAG>CAG	p.E1301Q	ALPK2_uc002lhk.1_Missense_Mutation_p.E632Q	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1301							ATP binding|protein serine/threonine kinase activity	p.H1301H(1)		ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TCAGCATCCTCTGGACTGTGA	0.507													0	0	0	0.009535	0	23	50										G	56203518	C	G	56203518	3	3	99	1	0	0	0	0	1	0	0	0	545	922	32	1	2647	1	ALPK2	18	56203518	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	10636495	56203518	21873730	379	30520										
ZNF532	55205	broad.mit.edu	37	chr18	56587297	56587297	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtgctgagcagtgtcaatcCagtccctgtttacatcccaa	9	12	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:56587297C>T	uc002lho.2	+	4	2325	c.1778C>T	c.(1777-1779)CCA>CTA	p.P593L	ZNF532_uc002lhp.2_Missense_Mutation_p.P591L|ZNF532_uc010xeg.1_Missense_Mutation_p.P591L|ZNF532_uc002lhr.2_Missense_Mutation_p.P591L|ZNF532_uc002lhs.2_Missense_Mutation_p.P591L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGTGTCAATCCAGTCCCTGTT	0.557													0	0	0	0.008291	0	10	26										T	56587297	C	T	56587297	3	4	99	1	0	0	0	0	1	0	0	0	17969	594	21	2	1780	2	ZNF532	18	56587297	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	383779	56587297	21489951	380	30521										
CCBE1	147372	broad.mit.edu	37	chr18	57363928	57363928	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agtcgtcgcgattttgctctCtgagcagatttctctatgaa	9	9	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:57363928C>A	uc002lib.2	-	2	215	c.145G>T	c.(145-147)GAG>TAG	p.E49*		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	49					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				ATTTTGCTCTCTGAGCAGATT	0.587											OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.32078e-09	0.003163	2.46325e-09	10	54										A	57363928	C	A	57363928	4	1	99	1	0	0	0	0	0	1	0	0	2731	922	32	3	1115	3	CCBE1	18	57363928	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	776631	57363928	20713320	381	30522										
NFATC1	4772	broad.mit.edu	37	chr18	77246380	77246380	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatgccacccgaccccagctCctgcctcgtggccggcttcc	10	20	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:77246380C>G	uc010xfg.1	+	9	2678	c.2225C>G	c.(2224-2226)TCC>TGC	p.S742C	NFATC1_uc002lnd.2_Missense_Mutation_p.S742C|NFATC1_uc002lne.2_Missense_Mutation_p.S270C|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Missense_Mutation_p.S270C|NFATC1_uc002lnf.2_Missense_Mutation_p.S729C|NFATC1_uc002lng.2_Missense_Mutation_p.S729C|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	742	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GACCCCAGCTCCTGCCTCGTG	0.662													0	0	0	0.01441	0	57	129										G	77246380	C	G	77246380	3	3	99	1	0	0	0	0	1	0	0	0	10361	855	30	1	2410	1	NFATC1	18	77246380	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	19882452	77246380	830868	382	30523										
MKNK2	2872	broad.mit.edu	37	chr19	2042510	2042510	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggtcgaagtcacagatcttCacgggggagacctgggaggg	17	8	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:2042510C>T	uc002lus.2	-	10	911	c.666G>A	c.(664-666)GTG>GTA	p.V222V	MKNK2_uc002luq.1_5'Flank|MKNK2_uc010xgu.1_Silent_p.V61V|MKNK2_uc010xgv.1_Silent_p.V91V|MKNK2_uc002lur.2_Silent_p.V222V|MKNK2_uc002lut.1_5'UTR	NM_199054	NP_951009	Q9HBH9	MKNK2_HUMAN	MAP kinase-interacting serine/threonine kinase 2	222	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(1)|breast(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACAGATCTTCACGGGGGAGA	0.692													0	0	0	0.001168	0	3	3										T	2042510	C	T	2042510	2	4	99	1	0	0	0	0	0	0	0	1	9605	813	29	1		1	MKNK2	19	2042510	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		2042510	57086473	383	30524										
ZNF77	58492	broad.mit.edu	37	chr19	2933592	2933592	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctctctccagtgtgcgttctCacgtgcacacgaagggacga	11	13	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:2933592C>G	uc002lws.3	-	4	1664	c.1533G>C	c.(1531-1533)GTG>GTC	p.V511V		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	511	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCGTTCTCACGTGCACAC	0.493													0	0	0	0.009718	0	37	74										G	2933592	C	G	2933592	2	3	99	1	0	0	0	0	0	0	0	1	18139	813	29	1		1	ZNF77	19	2933592	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	891082	2933592	56195391	384	30525										
C19orf29	58509	broad.mit.edu	37	chr19	3620192	3620192	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtcttgaagtgctctgcctCcttctcgcgctgcagcatct	9	14	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:3620192C>A	uc002lyh.2	-	4	870	c.817G>T	c.(817-819)GAG>TAG	p.E273*	C19orf29_uc010xho.1_5'Flank|C19orf29_uc010dtn.2_Nonsense_Mutation_p.E121*|C19orf29_uc002lyi.3_Nonsense_Mutation_p.E273*|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	273	Potential.					catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTCTGCCTCCTTCTCGCGC	0.672													1	0	1.58986e-06	0.008291	1.65149e-06	7	20										A	3620192	C	A	3620192	4	1	99	1	0	0	0	0	0	1	0	0	1918	864	30	3	1487	3	C19orf29	19	3620192	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	686600	3620192	55508791	385	30526										
UHRF1	29128	broad.mit.edu	37	chr19	4910993	4910993	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaggagctgaggcggaagatCcaggagctgttccacgtgga	17	8	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4910993C>A	uc002mbo.2	+	2	264	c.96C>A	c.(94-96)ATC>ATA	p.I32I	uc002mbn.1_5'Flank|UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Silent_p.I45I	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	32	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GGCGGAAGATCCAGGAGCTGT	0.622											OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.28615e-30	0.01441	3.62424e-30	55	78										A	4910993	C	A	4910993	2	1	99	1	0	0	0	0	0	0	0	1	16964	845	30	3		3	UHRF1	19	4910993	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1290801	4910993	54217990	386	30527										
UHRF1	29128	broad.mit.edu	37	chr19	4911005	4911005	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggaagatccaggagctgttCcacgtggagccaggcctgca	14	12	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4911005C>T	uc002mbo.2	+	2	276	c.108C>T	c.(106-108)TTC>TTT	p.F36F	uc002mbn.1_5'Flank|UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Silent_p.F49F	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	36	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		AGGAGCTGTTCCACGTGGAGC	0.637											OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	56	74										T	4911005	C	T	4911005	2	4	99	1	0	0	0	0	0	0	0	1	16964	854	30	1		1	UHRF1	19	4911005	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	12	4911005	54217978	387	30528										
CRB3	92359	broad.mit.edu	37	chr19	6466563	6466563	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggctggcactgttggtgcgGaagcttcgggagaagcggca	19	8	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:6466563G>A	uc002mey.2	+	4	774	c.243G>A	c.(241-243)CGG>CGA	p.R81R	CRB3_uc002mez.2_Silent_p.R81R|CRB3_uc002mfa.2_Silent_p.R81R	NM_139161	NP_631900	Q9BUF7	CRUM3_HUMAN	crumbs 3 isoform a precursor	81	Cytoplasmic (Potential).				protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0						TGTTGGTGCGGAAGCTTCGGG	0.652													0	0	0	0.01441	0	83	98										A	6466563	G	A	6466563	2	1	99	1	0	0	0	0	0	0	0	1	3850	1161	41	1		1	CRB3	19	6466563	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1555558	6466563	52662420	388	30529										
MYO1F	4542	broad.mit.edu	37	chr19	8615474	8615474	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctctccactcgggcgtaattCccgtcttcacagaaactgat	7	14	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:8615474C>T	uc002mkg.2	-	9	990	c.876G>A	c.(874-876)GGG>GGA	p.G292G	MYO1F_uc002mkh.2_Silent_p.G292G	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	292	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GGGCGTAATTCCCGTCTTCAC	0.607													0	0	0	0.011902	0	34	75										T	8615474	C	T	8615474	2	4	99	1	0	0	0	0	0	0	0	1	10073	842	30	1		1	MYO1F	19	8615474	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2148911	8615474	50513509	389	30530										
KEAP1	9817	broad.mit.edu	37	chr19	10602630	10602630	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ttgggcgcccggcagggcatCacctgcgtgggcttgtgcag	17	12	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:10602630C>T	uc002moq.1	-	3	1104	c.948G>A	c.(946-948)GTG>GTA	p.V316V	KEAP1_uc002mop.1_Silent_p.V34V|KEAP1_uc002mor.1_Silent_p.V316V	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGCAGGGCATCACCTGCGTGG	0.637													0	0	0	0.004007	0	14	22										T	10602630	C	T	10602630	2	4	99	1	0	0	0	0	0	0	0	1	8141	813	29	1		1	KEAP1	19	10602630	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1987156	10602630	48526353	390	30531										
KEAP1	9817	broad.mit.edu	37	chr19	10602848	10602848	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gatgcaggcgtggaagacctCggactcgcagcgcacgttca	14	12	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:10602848C>T	uc002moq.1	-	3	886	c.730G>A	c.(730-732)GAG>AAG	p.E244K	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.E244K	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	244	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TGGAAGACCTCGGACTCGCAG	0.627													0	0	0	0.00499	0	16	48										T	10602848	C	T	10602848	3	4	99	1	0	0	0	0	1	0	0	0	8141	893	31	1	1160	1	KEAP1	19	10602848	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	218	10602848	48526135	391	30532										
CCDC151	115948	broad.mit.edu	37	chr19	11545659	11545659	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cagagggcttccctgcacctCtgtggaaggatcctcccttg	11	14	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:11545659C>G	uc002mrs.2	-	1	322	c.179G>C	c.(178-180)AGA>ACA	p.R60T	CCDC151_uc010dxz.2_Missense_Mutation_p.R60T|PRKCSH_uc002mrt.2_5'Flank|PRKCSH_uc002mru.2_5'Flank|PRKCSH_uc010xlz.1_5'Flank|PRKCSH_uc010dya.2_5'Flank|PRKCSH_uc002mrv.1_5'Flank|PRKCSH_uc010dyb.2_5'Flank	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	60										ovary(1)	1						CCCTGCACCTCTGTGGAAGGA	0.597											OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	21	58										G	11545659	C	G	11545659	3	3	99	1	0	0	0	0	1	0	0	0	2786	913	32	1	1660	1	CCDC151	19	11545659	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	942811	11545659	47583324	392	30533										
ZNF441	126068	broad.mit.edu	37	chr19	11891595	11891595	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atgtggaaaaggctttctttCtcccagttcagttcgaagac	9	9	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:11891595C>T	uc010dyj.2	+	4	1150	c.956C>T	c.(955-957)TCT>TTT	p.S319F	ZNF441_uc002msn.3_Missense_Mutation_p.S275F	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	319	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGCTTTCTTTCTCCCAGTTCA	0.403													0	0	0	0.007291	0	29	48										T	11891595	C	T	11891595	3	4	99	1	0	0	0	0	1	0	0	0	17911	913	32	1	970	1	ZNF441	19	11891595	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	345936	11891595	47237388	393	30534										
WDR83	84292	broad.mit.edu	37	chr19	12786441	12786441	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gccatgggaggcagcgtccaGtgctggcgagaggaggccta	18	10	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:12786441G>T	uc002mue.3	+	11	1238	c.903G>T	c.(901-903)CAG>CAT	p.Q301H	WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_Missense_Mutation_p.Q301H	NM_001099737	NP_001093207	Q9BRX9	WDR83_HUMAN	mitogen-activated protein kinase organizer 1	301	WD 7.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2						GCAGCGTCCAGTGCTGGCGAG	0.647											OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	5.4927e-09	0.004482	5.78406e-09	7	14										T	12786441	G	T	12786441	3	4	99	1	0	0	0	0	1	0	0	0	17329	1020	36	4	937	4	WDR83	19	12786441	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	894846	12786441	46342542	394	30535										
OR10H2	26538	broad.mit.edu	37	chr19	15839103	15839103	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcatcccgcgcatgctggccGacctgctgtccacccagcgc	10	19	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:15839103G>A	uc002nbm.2	+	1	270	c.250G>A	c.(250-252)GAC>AAC	p.D84N		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CATGCTGGCCGACCTGCTGTC	0.622													0	0	0	0.00499	0	3	45										A	15839103	G	A	15839103	3	1	99	1	0	0	0	0	1	0	0	0	10906	1058	37	1	252	1	OR10H2	19	15839103	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3052662	15839103	43289880	395	30536										
C19orf42	79086	broad.mit.edu	37	chr19	16770802	16770802	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agcaccgccccggcattcatCagcaacgtcctgcagaggga	11	15	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:16770802C>T	uc002ner.2	-	2	83	c.36G>A	c.(34-36)CTG>CTA	p.L12L	TMEM38A_uc002nes.2_5'Flank|C19orf42_uc002neo.1_RNA|C19orf42_uc002nep.1_RNA	NM_024104	NP_077009	Q9BQ49	CS042_HUMAN	hypothetical protein LOC79086 precursor	12						integral to membrane					0						CGGCATTCATCAGCAACGTCC	0.617													0	0	0	0.006214	0	7	26										T	16770802	C	T	16770802	2	4	99	1	0	0	0	0	0	0	0	1	1925	813	29	1		1	C19orf42	19	16770802	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	931699	16770802	42358181	396	30537										
UPF1	5976	broad.mit.edu	37	chr19	18943112	18943112	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gcgccgacacacagggctccGagttcgagttcaccgacttt	11	14	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:18943112G>C	uc002nkg.2	+	1	369	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	UPF1_uc002nkf.2_Missense_Mutation_p.E32Q	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	32	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACAGGGCTCCGAGTTCGAGTT	0.443													0	0	0	0.00874	0	30	35										C	18943112	G	C	18943112	3	2	99	1	0	0	0	0	1	0	0	0	17000	1059	37	1	96	1	UPF1	19	18943112	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	2172310	18943112	40185871	397	30538										
ZNF737	100129842	broad.mit.edu	37	chr19	20727954	20727954	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtgtagtaagggatgagaagTacttaaaggctctgccacat	12	6	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:20727954T>C	uc002npa.2	-	4	1235	c.1055A>G	c.(1054-1056)TAC>TGC	p.Y352C		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	352					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GGATGAGAAGTACTTAAAGGC	0.418													0	0	0	0.010504	0	20	36										C	20727954	T	C	20727954	3	2	99	1	0	0	0	0	1	0	0	0	18123	1638	57	5	559	5	ZNF737	19	20727954	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	1784842	20727954	38401029	398	30539										
ZNF492	57615	broad.mit.edu	37	chr19	22847709	22847709	+	Missense_Mutation	SNP	T	T	A													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acaacttactacacataagaTaattcatactggagagaaac							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:22847709T>A	uc002nqw.3	+	4	1482	c.1238T>A	c.(1237-1239)ATA>AAA	p.I413K		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	413	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACACATAAGATAATTCATACT	0.368													0	0	0	0.00623	0	31	56										A	22847709	T	A	22847709	3	1	99	1	0	0	0	0	1	0	0	0	17940	1406	49	5	1248	5	ZNF492	19	22847709	Missense_Mutation	SNP	T	TCGA-G2-A3IE-01A-11D-A20D-08	2119755	22847709	36281274	399	30540	153	2								
ZNF492	57615	broad.mit.edu	37	chr19	22847715	22847715	+	Missense_Mutation	SNP	A	A	G													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tactacacataagataattcAtactggagagaaaccctaca							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:22847715A>G	uc002nqw.3	+	4	1488	c.1244A>G	c.(1243-1245)CAT>CGT	p.H415R		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	415	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAGATAATTCATACTGGAGAG	0.378													0	0	0	0.003755	0	27	54										G	22847715	A	G	22847715	3	3	99	1	0	0	0	0	1	0	0	0	17940	217	8	5	1254	5	ZNF492	19	22847715	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	6	22847715	36281268	400	30541	153	2								
PLEKHG2	64857	broad.mit.edu	37	chr19	39909624	39909624	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cctcttctttgagaaccaccCtgcctccatccctgccaagg	6	18	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:39909624C>G	uc010xuz.1	+	11	1569	c.1244C>G	c.(1243-1245)CCT>CGT	p.P415R	PLEKHG2_uc010xuy.1_Missense_Mutation_p.P356R|PLEKHG2_uc002olj.2_Missense_Mutation_p.P415R|PLEKHG2_uc010xva.1_Missense_Mutation_p.P222R	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	415					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GAGAACCACCCTGCCTCCATC	0.602													0	0	0	0.00245	0	13	82										G	39909624	C	G	39909624	3	3	99	1	0	0	0	0	1	0	0	0	12069	681	24	4	1282	4	PLEKHG2	19	39909624	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	17061909	39909624	19219359	401	30542										
MAP3K10	4294	broad.mit.edu	37	chr19	40710537	40710537	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agccctttgcccgcctcctgGagggtgagccggggccccgt	15	16	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:40710537G>A	uc002ona.2	+	3	1297	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	337	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						CCGCCTCCTGGAGGGTGAGCC	0.652													0	0	0	0.003163	0	11	22										A	40710537	G	A	40710537	3	1	99	1	0	0	0	0	1	0	0	0	9244	1175	41	1	1019	1	MAP3K10	19	40710537	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	800913	40710537	18418446	402	30543										
HIPK4	147746	broad.mit.edu	37	chr19	40886736	40886736	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acagtagtagggggtcccatCttctgcggccacgacgggcg	15	12	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:40886736C>A	uc002onp.2	-	3	1447	c.1162G>T	c.(1162-1164)GAT>TAT	p.D388Y		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	388						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GGGGTCCCATCTTCTGCGGCC	0.662													1	0	9.57592e-29	0.01441	1.04963e-28	39	41										A	40886736	C	A	40886736	3	1	99	1	0	0	0	0	1	0	0	0	7119	913	32	3	696	3	HIPK4	19	40886736	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	176199	40886736	18242247	403	30544										
ARHGEF1	9138	broad.mit.edu	37	chr19	42407459	42407459	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctctcccttgcctgcagaaGagcccacagaacgggagaaa	10	13	1	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:42407459G>A	uc002orx.2	+	19	1850	c.1741G>A	c.(1741-1743)GAG>AAG	p.E581K	ARHGEF1_uc002ory.2_Missense_Mutation_p.E548K|ARHGEF1_uc002orz.2_Missense_Mutation_p.E419K|ARHGEF1_uc002osa.2_Missense_Mutation_p.E596K|ARHGEF1_uc002osb.2_Missense_Mutation_p.E563K|ARHGEF1_uc002osc.2_Missense_Mutation_p.E335K|ARHGEF1_uc002osd.2_Missense_Mutation_p.E240K|ARHGEF1_uc002ose.2_Missense_Mutation_p.E25K	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	581	DH.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GCCTGCAGAAGAGCCCACAGA	0.557													0	0	0	0.001984	0	5	21										A	42407459	G	A	42407459	3	1	99	1	0	0	0	0	1	0	0	0	893	943	33	1	1860	1	ARHGEF1	19	42407459	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1520723	42407459	16721524	404	30545										
ZNF574	64763	broad.mit.edu	37	chr19	42583877	42583877	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtagactgtggcctggccttCggcacagaggccctcctcct	12	15	0	2	rs113091672		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:42583877C>T	uc002osm.3	+	2	1288	c.1119C>T	c.(1117-1119)TTC>TTT	p.F373F	ZNF574_uc002osk.3_Silent_p.F463F	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	373	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GCCTGGCCTTCGGCACAGAGG	0.587													0	0	0	0.006214	0	7	31										T	42583877	C	T	42583877	2	4	99	1	0	0	0	0	0	0	0	1	18003	883	31	1		1	ZNF574	19	42583877	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	176418	42583877	16545106	405	30546										
GLTSCR1	29998	broad.mit.edu	37	chr19	48197590	48197590	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccccaactctgcctggcatCtttgtcatccaaaaccagct	5	17	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:48197590C>G	uc002phh.3	+	8	2696	c.2502C>G	c.(2500-2502)ATC>ATG	p.I834M	GLTSCR1_uc002phi.3_Missense_Mutation_p.I592M	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	834							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		TGCCTGGCATCTTTGTCATCC	0.721													0	0	0	0.014323	0	19	9										G	48197590	C	G	48197590	3	3	99	1	0	0	0	0	1	0	0	0	6474	903	32	1	2524	1	GLTSCR1	19	48197590	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	5613713	48197590	10931393	406	30547										
PIH1D1	55011	broad.mit.edu	37	chr19	49954846	49954846	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgccatggccctgggaaagaGatctaggcgtcctcgagacc	13	13	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:49954846G>C	uc002pns.2	-	1	270	c.-14C>G	c.(-16--12)ATCTC>ATGTC		PIH1D1_uc010yap.1_Translation_Start_Site|PIH1D1_uc010yaq.1_Translation_Start_Site|ALDH16A1_uc002pnt.2_5'Flank|ALDH16A1_uc010yar.1_5'Flank|ALDH16A1_uc010yas.1_5'Flank|ALDH16A1_uc010yat.1_5'Flank	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17						box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		CTGGGAAAGAGATCTAGGCGT	0.607													0	0	0	0.004482	0	4	25										C	49954846	G	C	49954846	1	2	99	1	0	0	0	0	0	0	0	0	11906	957	33	1		1	PIH1D1	19	49954846	Translation_Start_Site	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1757256	49954846	9174137	407	30548										
SCAF1	58506	broad.mit.edu	37	chr19	50155777	50155777	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccatcacggtgggccggcttGacaagtccgacccccgagga	13	15	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50155777G>A	uc002poq.2	+	7	2255	c.2131G>A	c.(2131-2133)GAC>AAC	p.D711N		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	711	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GGGCCGGCTTGACAAGTCCGA	0.711													0	0	0	0.004007	0	15	10										A	50155777	G	A	50155777	3	1	99	1	0	0	0	0	1	0	0	0	13868	1290	45	1	2153	1	SCAF1	19	50155777	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	200931	50155777	8973206	408	30549										
ZNF473	25888	broad.mit.edu	37	chr19	50548458	50548458	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgaccggaatgcttccctttCtgtgtatccgaaaactcaca	7	12	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50548458C>T	uc002prn.2	+	5	995	c.758C>T	c.(757-759)TCT>TTT	p.S253F	ZNF473_uc002prm.2_Missense_Mutation_p.S253F|ZNF473_uc010ybo.1_Missense_Mutation_p.S241F	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	253					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GCTTCCCTTTCTGTGTATCCG	0.453													0	0	0	0.01441	0	43	223										T	50548458	C	T	50548458	3	4	99	1	0	0	0	0	1	0	0	0	17928	913	32	1	772	1	ZNF473	19	50548458	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	392681	50548458	8580525	409	30550										
NR1H2	7376	broad.mit.edu	37	chr19	50881973	50881973	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gtgtccagctaacagcggctCaagaactaatgatccagcag	10	11	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50881973C>T	uc010enw.2	+	7	946	c.670C>T	c.(670-672)CAA>TAA	p.Q224*	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Nonsense_Mutation_p.Q223*|NR1H2_uc002psa.3_Nonsense_Mutation_p.Q126*	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	223					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AACAGCGGCTCAAGAACTAAT	0.632													0	0	0	0.004656	0	27	30										T	50881973	C	T	50881973	4	4	99	1	0	0	0	0	0	1	0	0	10617	827	29	1	681	1	NR1H2	19	50881973	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	333515	50881973	8247010	410	30551										
ACPT	93650	broad.mit.edu	37	chr19	51295390	51295390	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agctgctgcgggaggccaccGaggccgccgagtaccaggag	17	13	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:51295390G>A	uc002pta.1	+	5	511	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	171	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGAGGCCACCGAGGCCGCCGA	0.582													0	0	0	0.00308	0	6	6										A	51295390	G	A	51295390	3	1	99	1	0	0	0	0	1	0	0	0	168	1059	37	1	529	1	ACPT	19	51295390	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	413417	51295390	7833593	411	30552										
LILRB5	10990	broad.mit.edu	37	chr19	54758713	54758713	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gaggtcacaggactcatggaGaattcagcctggtgtctata	12	8	4	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:54758713G>C	uc002qex.2	-	6	1251	c.1140C>G	c.(1138-1140)TTC>TTG	p.F380L	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.F371L|LILRB5_uc002qey.2_Missense_Mutation_p.F380L|LILRB5_uc002qez.2_Missense_Mutation_p.F280L|LILRB5_uc002qfa.1_Missense_Mutation_p.F270L|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	380	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACTCATGGAGAATTCAGCCT	0.547													0	0	0	0.003755	0	27	87										C	54758713	G	C	54758713	3	2	99	1	0	0	0	0	1	0	0	0	8794	933	33	1	667	1	LILRB5	19	54758713	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3463323	54758713	4370270	412	30553										
PEG3	5178	broad.mit.edu	37	chr19	57335838	57335838	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tttcggagtttgatcagggtCttccgaggcccaacaaattc	10	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:57335838C>T	uc002qnu.2	-	1	537	c.186G>A	c.(184-186)AAG>AAA	p.K62K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.K62K|PEG3_uc002qnv.2_Silent_p.K62K|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Silent_p.K62K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	62	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGATCAGGGTCTTCCGAGGCC	0.512													0	0	0	0.004007	0	12	73										T	57335838	C	T	57335838	2	4	99	1	0	0	0	0	0	0	0	1	11720	912	32	1		1	PEG3	19	57335838	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2577125	57335838	1793145	413	30554										
A1BG	1	broad.mit.edu	37	chr19	58864380	58864381	+	Frame_Shift_Del	DEL	CC	CC	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggtagcggccctgggtgtcaCccgtcagcaggaactggtgc							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:58864380_58864381delCC	uc002qsd.3	-	3	315_316	c.253_254delGG	c.(253-255)GGTfs	p.G85fs	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	85	Ig-like V-type 1.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CTGGGTGTCACCCGTCAGCAGG	0.634																		16	67	---	---								-	58864381	CC	-	58864380	7	5	99	1	0	1	0	1	0	0	0	0	1	507	18	0	1257	0	A1BG	19	58864380	Frame_Shift_Del	DEL	CC	TCGA-G2-A3IE-01A-11D-A20D-08	1528542	58864380	264603	414	30555										
PSMF1	9491	broad.mit.edu	37	chr20	1106163	1106163	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gggtcccaatgataagaagtCagaactgctgccagctgggt	13	9	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:1106163C>T	uc002wel.3	+	3	320	c.152C>T	c.(151-153)TCA>TTA	p.S51L	PSMF1_uc010zpo.1_5'UTR|PSMF1_uc002wem.3_Missense_Mutation_p.S51L|PSMF1_uc010zpp.1_Missense_Mutation_p.S51L|PSMF1_uc002wen.3_Missense_Mutation_p.S51L	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	51					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						GATAAGAAGTCAGAACTGCTG	0.378													0	0	0	0.007413	0	13	37										T	1106163	C	T	1106163	3	4	99	1	0	0	0	0	1	0	0	0	12710	838	29	1	158	1	PSMF1	20	1106163	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		1106163	61919357	415	30556										
TM9SF4	9777	broad.mit.edu	37	chr20	30753246	30753246	+	Nonstop_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgctgctgtgaagatagactGattggagtggaccacggcca	14	8	0	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:30753246G>C	uc002wxj.2	+	18	2163	c.1928G>C	c.(1927-1929)TGA>TCA	p.*643S	TM9SF4_uc010zts.1_Nonstop_Mutation_p.*550S|TM9SF4_uc002wxk.2_Nonstop_Mutation_p.*626S|TM9SF4_uc010gdz.2_Nonstop_Mutation_p.*522S	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	643						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAGATAGACTGATTGGAGTGG	0.537													0	0	0	0.010818	0	26	40										C	30753246	G	C	30753246	4	2	99	1	0	0	0	0	0	0	0	0	15977	1285	45	1	1998	1	TM9SF4	20	30753246	Nonstop_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	29647083	30753246	32272274	416	30557										
POFUT1	23509	broad.mit.edu	37	chr20	30816133	30816133	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cccagttccccgtcctagagGaacacaggccactacagaag	9	15	0	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:30816133G>A	uc002wxp.2	+	5	659	c.610G>A	c.(610-612)GAA>AAA	p.E204K	POFUT1_uc010ztt.1_Missense_Mutation_p.E96K|POFUT1_uc010ztu.1_5'UTR	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	204					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CGTCCTAGAGGAACACAGGCC	0.557													0	0	0	0.014323	0	20	40										A	30816133	G	A	30816133	3	1	99	1	0	0	0	0	1	0	0	0	12183	1175	41	1	675	1	POFUT1	20	30816133	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	62887	30816133	32209387	417	30558										
PLCG1	5335	broad.mit.edu	37	chr20	39802354	39802354	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acttccagatcagtaaccctGaatttgcctttctgcgcttc	6	13	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:39802354G>A	uc002xjp.1	+	29	3578	c.3457G>A	c.(3457-3459)GAA>AAA	p.E1153K	PLCG1_uc002xjo.1_Missense_Mutation_p.E1153K|PLCG1_uc010zwe.1_Missense_Mutation_p.E818K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1153	C2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CAGTAACCCTGAATTTGCCTT	0.507											OREG0025953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	46	98										A	39802354	G	A	39802354	3	1	99	1	0	0	0	0	1	0	0	0	12035	1291	45	1	3571	1	PLCG1	20	39802354	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	8986221	39802354	23223166	418	30559										
PTPRT	11122	broad.mit.edu	37	chr20	41385232	41385232	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gctgagaagcgcctgtggttGaccacacgggtgaccatcag	14	11	1	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:41385232G>C	uc002xkg.2	-	6	913	c.729C>G	c.(727-729)GTC>GTG	p.V243V	PTPRT_uc010ggj.2_Silent_p.V243V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	243	Extracellular (Potential).|Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCTGTGGTTGACCACACGGG	0.582													0	0	0	0.004482	0	7	21										C	41385232	G	C	41385232	2	2	99	1	0	0	0	0	0	0	0	1	12812	1277	45	1		1	PTPRT	20	41385232	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1582878	41385232	21640288	419	30560										
PTPRT	11122	broad.mit.edu	37	chr20	41419965	41419965	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccttcacgtagacgttcaagGcccctgggctggacctgtca	11	14	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:41419965G>A	uc002xkg.2	-	3	540	c.356C>T	c.(355-357)GCC>GTC	p.A119V	PTPRT_uc010ggj.2_Missense_Mutation_p.A119V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	119	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GACGTTCAAGGCCCCTGGGCT	0.597													0	0	0	0.010771	0	34	44										A	41419965	G	A	41419965	3	1	99	1	0	0	0	0	1	0	0	0	12812	1203	42	2	4146	2	PTPRT	20	41419965	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	34733	41419965	21605555	420	30561										
RIMS4	140730	broad.mit.edu	37	chr20	43385652	43385652	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggcaatgcagatgccattctCtagcaggtaggccttgatgt	12	9	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:43385652C>G	uc002xms.2	-	5	478	c.478G>C	c.(478-480)GAG>CAG	p.E160Q	RIMS4_uc010ggu.2_Missense_Mutation_p.E161Q	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	160	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				ATGCCATTCTCTAGCAGGTAG	0.562													0	0	0	0.01441	0	93	205										G	43385652	C	G	43385652	3	3	99	1	0	0	0	0	1	0	0	0	13370	922	32	1	339	1	RIMS4	20	43385652	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1965687	43385652	19639868	421	30562										
SYS1	90196	broad.mit.edu	37	chr20	43995738	43995738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agatacccctcaactcagccCctaaatccaatgtctagaat	4	14	3	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:43995738C>T	uc002xnv.2	+	4	712	c.454C>T	c.(454-456)CCT>TCT	p.P152S	SYS1_uc010gha.2_RNA|SYS1_uc002xnw.1_Intron|SYS1-DBNDD2_uc002xnx.2_Intron	NM_033542	NP_291020	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein	152					protein transport	Golgi membrane|integral to membrane				skin(1)	1		Myeloproliferative disorder(115;0.0122)				CAACTCAGCCCCTAAATCCAA	0.577													0	0	0	0.005524	0	33	77										T	43995738	C	T	43995738	3	4	99	1	0	0	0	0	1	0	0	0	15461	623	22	2	464	2	SYS1	20	43995738	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	610086	43995738	19029782	422	30563										
UBE2C	11065	broad.mit.edu	37	chr20	44442074	44442074	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accccgaatactcttttttcAggctacagcaggagctgatg	9	11	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:44442074A>G	uc002xpm.2	+	2	182	c.102_splice	c.e2-2	p.R34_splice	UBE2C_uc002xpl.2_Splice_Site_p.R34_splice|UBE2C_uc002xpn.2_5'UTR|UBE2C_uc002xpo.2_Splice_Site_p.R34_splice|UBE2C_uc002xpp.2_Splice_Site_p.R34_splice|UBE2C_uc002xpq.2_Splice_Site	NM_007019	NP_008950	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C isoform 1						activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Myeloproliferative disorder(115;0.0122)				CTCTTTTTTCAGGCTACAGCA	0.542													0	0	0	0.01441	0	32	125										G	44442074	A	G	44442074	5	3	99	1	0	0	0	0	0	0	1	0	16843	202	7	5	106	5	UBE2C	20	44442074	Splice_Site	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	446336	44442074	18583446	423	30564										
SLC12A5	57468	broad.mit.edu	37	chr20	44684813	44684813	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agagtatcacagatgagtcaCgaggctcaatccggagaaag	12	8	3	4			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:44684813C>G	uc010zxl.1	+	22	2957	c.2881C>G	c.(2881-2883)CGA>GGA	p.R961G	SLC12A5_uc002xrb.2_Missense_Mutation_p.R938G	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	961	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGATGAGTCACGAGGCTCAAT	0.547													0	0	0	0.006122	0	13	31										G	44684813	C	G	44684813	3	3	99	1	0	0	0	0	1	0	0	0	14386	528	19	4	3023	4	SLC12A5	20	44684813	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	242739	44684813	18340707	424	30565										
MOCS3	27304	broad.mit.edu	37	chr20	49576335	49576335	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgaagccttctgtggctcctCagccactgataaatgccgct	9	13	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:49576335C>A	uc002xvy.1	+	1	973	c.956C>A	c.(955-957)TCA>TAA	p.S319*	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	319					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						TGTGGCTCCTCAGCCACTGAT	0.587													1	0	2.89027e-11	0.014323	3.09218e-11	19	63										A	49576335	C	A	49576335	4	1	99	1	0	0	0	0	0	1	0	0	9692	838	29	3	958	3	MOCS3	20	49576335	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4891522	49576335	13449185	425	30566										
GATA5	140628	broad.mit.edu	37	chr20	61041539	61041539	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	acgggctccccctccgagttCcgccgccacagcgtggtgtt	12	17	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:61041539C>T	uc002ycx.1	-	4	830	c.768G>A	c.(766-768)CGG>CGA	p.R256R		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	256	GATA-type 2.				blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CCTCCGAGTTCCGCCGCCACA	0.706													0	0	0	0.008291	0	7	10										T	61041539	C	T	61041539	2	4	99	1	0	0	0	0	0	0	0	1	6257	842	30	1		1	GATA5	20	61041539	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	11465204	61041539	1983981	426	30567										
SLCO4A1	28231	broad.mit.edu	37	chr20	61299480	61299480	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctccttctggttttcatattCgttgtaattttctttacatt	4	8	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:61299480C>A	uc002ydb.1	+	9	1960	c.1755C>A	c.(1753-1755)TTC>TTA	p.F585L	SLCO4A1_uc002ydc.1_Intron|LOC100127888_uc002ydd.2_5'Flank|SLCO4A1_uc002yde.1_Intron	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	585	Helical; Name=10; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TTTTCATATTCGTTGTAATTT	0.488											OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.6726e-16	0.003954	3.94492e-16	23	56										A	61299480	C	A	61299480	3	1	99	1	0	0	0	0	1	0	0	0	14729	883	31	3	1785	3	SLCO4A1	20	61299480	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	257941	61299480	1726040	427	30568										
TPTE	7179	broad.mit.edu	37	chr21	10906963	10906963	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tctcgccaaaaagtatctccAcggcaaaatctgatggataa	7	10	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:10906963A>T	uc002yip.1	-	24	1966	c.1598T>A	c.(1597-1599)GTG>GAG	p.V533E	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V515E|TPTE_uc002yir.1_Missense_Mutation_p.V495E|TPTE_uc010gkv.1_Missense_Mutation_p.V395E	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	533	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGTATCTCCACGGCAAAATC	0.353													0	0	0	0.001855	0	11	85										T	10906963	A	T	10906963	3	4	99	1	0	0	0	0	1	0	0	0	16427	159	6	5	61	5	TPTE	21	10906963	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08		10906963	37222932	428	30569										
CXADR	1525	broad.mit.edu	37	chr21	18933792	18933792	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aaggaagttcatcacgatatCaggtaattaagtgagacagg	11	5	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:18933792C>T	uc002yki.2	+	6	949	c.831C>T	c.(829-831)ATC>ATT	p.I277I	CXADR_uc002ykh.1_Intron|CXADR_uc010gld.1_Intron|CXADR_uc010gle.1_Intron|CXADR_uc002ykj.1_Silent_p.I250I	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	277	Cytoplasmic (Potential).				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		ATCACGATATCAGGTAATTAA	0.363													0	0	0	0.00278	0	16	25										T	18933792	C	T	18933792	2	4	99	1	0	0	0	0	0	0	0	1	4076	816	29	1		1	CXADR	21	18933792	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	8026829	18933792	29196103	429	30570										
TIAM1	7074	broad.mit.edu	37	chr21	32598123	32598123	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	attttcttcatcttttcatcCatgtcaatcttctgttccag	3	11	7	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:32598123C>T	uc002yow.1	-	8	2200	c.1728G>A	c.(1726-1728)ATG>ATA	p.M576I	TIAM1_uc011adk.1_Missense_Mutation_p.M576I|TIAM1_uc011adl.1_Missense_Mutation_p.M576I|TIAM1_uc002yox.1_Missense_Mutation_p.M184I	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	576					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCTTTTCATCCATGTCAATCT	0.448													0	0	0	0.003954	0	22	45										T	32598123	C	T	32598123	3	4	99	1	0	0	0	0	1	0	0	0	15887	594	21	2	3135	2	TIAM1	21	32598123	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	13664331	32598123	15531772	430	30571										
SFRS15	57466	broad.mit.edu	37	chr21	33069064	33069064	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcaaatctatcaagcaacttCtggaataattatgtcaatat	4	7	5	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:33069064C>T	uc002ypd.2	-	8	1204	c.778_splice	c.e8-1	p.K260_splice	SFRS15_uc002ype.2_Splice_Site_p.K260_splice|SFRS15_uc010glu.2_Splice_Site_p.K245_splice|SFRS15_uc002ypf.1_Intron	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform							nucleus	nucleotide binding|RNA binding				0						CAAGCAACTTCTGGAATAATT	0.388													0	0	0	0.008361	0	23	50										T	33069064	C	T	33069064	5	4	99	1	0	0	0	0	0	0	1	0	14171	927	32	1	2718	1	SFRS15	21	33069064	Splice_Site	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	470941	33069064	15060831	431	30572										
IL10RB	3588	broad.mit.edu	37	chr21	34640812	34640812	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ggaacctgactttcacagctCagtacctaaggtgggtctgg	12	10	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34640812C>T	uc002yrk.1	+	2	262	c.163C>T	c.(163-165)CAG>TAG	p.Q55*	IL10RB_uc002yrh.1_Nonsense_Mutation_p.Q125*|IL10RB_uc002yri.1_Intron|uc002yrj.1_5'Flank|IL10RB_uc002yrl.1_Nonsense_Mutation_p.Q57*	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	55	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						TTTCACAGCTCAGTACCTAAG	0.532													0	0	0	0.014323	0	20	60										T	34640812	C	T	34640812	4	4	99	1	0	0	0	0	0	1	0	0	7621	827	29	1	169	1	IL10RB	21	34640812	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1571748	34640812	13489083	432	30573										
IFNAR1	3454	broad.mit.edu	37	chr21	34717650	34717650	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	catatgcaaacatgacctttCaagttcagtggctccagtaa	7	10	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34717650C>T	uc002yrn.2	+	6	919	c.772C>T	c.(772-774)CAA>TAA	p.Q258*	IFNAR1_uc011adv.1_Nonsense_Mutation_p.Q189*	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	258	Fibronectin type-III 2.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CATGACCTTTCAAGTTCAGTG	0.378													0	0	0	0.001855	0	9	30										T	34717650	C	T	34717650	4	4	99	1	0	0	0	0	0	1	0	0	7544	827	29	1	794	1	IFNAR1	21	34717650	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	76838	34717650	13412245	433	30574										
ITSN1	6453	broad.mit.edu	37	chr21	35166747	35166747	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aacgaaagatcatagaattaGaaaaacaaaaagaagaagcc	7	5	1	5			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:35166747G>C	uc002yta.1	+	17	2195	c.1927G>C	c.(1927-1929)GAA>CAA	p.E643Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E643Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E606Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E643Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E606Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E527Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E643Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E606Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E643Q|ITSN1_uc002ytc.1_Missense_Mutation_p.E643Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E606Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E643Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E577Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	643	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CATAGAATTAGAAAAACAAAA	0.383													0	0	0	0.00245	0	11	23										C	35166747	G	C	35166747	3	2	99	1	0	0	0	0	1	0	0	0	7926	943	33	1	1989	1	ITSN1	21	35166747	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	449097	35166747	12963148	434	30575										
ERG	2078	broad.mit.edu	37	chr21	39817505	39817505	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tggcgttccgtaggcacactCaaacaacgactggtcctcac	9	14	2	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:39817505C>G	uc010gnw.2	-	4	374	c.79G>C	c.(79-81)GAG>CAG	p.E27Q	ERG_uc002yxa.2_Missense_Mutation_p.E20Q|ERG_uc011aek.1_Intron|ERG_uc010gnv.2_Intron|ERG_uc010gnx.2_Missense_Mutation_p.E27Q|ERG_uc011ael.1_Missense_Mutation_p.E27Q|ERG_uc002yxb.2_Missense_Mutation_p.E27Q|ERG_uc011aem.1_Missense_Mutation_p.E20Q|ERG_uc002yxc.3_Missense_Mutation_p.E27Q	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	27					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				TAGGCACACTCAAACAACGAC	0.502													0	0	0	0.00333	0	18	40										G	39817505	C	G	39817505	3	3	99	1	0	0	0	0	1	0	0	0	5222	835	29	1	1417	1	ERG	21	39817505	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	4650758	39817505	8312390	435	30576										
IGSF5	150084	broad.mit.edu	37	chr21	41142978	41142978	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cggtctcctggtcagccattCaagctattattttgttccgg	9	11	3	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:41142978C>G	uc002yyo.2	+	4	657	c.554C>G	c.(553-555)TCA>TGA	p.S185*		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	185	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				GTCAGCCATTCAAGCTATTAT	0.537													0	0	0	0.004007	0	13	29										G	41142978	C	G	41142978	4	3	99	1	0	0	0	0	0	1	0	0	7602	838	29	1	568	1	IGSF5	21	41142978	Nonsense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1325473	41142978	6986917	436	30577										
TMPRSS3	64699	broad.mit.edu	37	chr21	43800263	43800263	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ccccatcctgacgtccagcaCacttttccatcggggaagtt	8	15	0	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:43800263C>A	uc002zbb.2	-	10	1212	c.1011G>T	c.(1009-1011)GTG>GTT	p.V337V	TMPRSS3_uc002zay.2_Silent_p.V95V|TMPRSS3_uc002zaz.2_Silent_p.V210V|TMPRSS3_uc002zba.2_Silent_p.V210V|TMPRSS3_uc002zbc.2_Silent_p.V337V	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	337	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						ACGTCCAGCACACTTTTCCAT	0.557													1	0	1.024e-07	0.000602	1.0741e-07	3	46										A	43800263	C	A	43800263	2	1	99	1	0	0	0	0	0	0	0	1	16245	465	17	4		4	TMPRSS3	21	43800263	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	2657285	43800263	4329632	437	30578										
PFKL	5211	broad.mit.edu	37	chr21	45743762	45743762	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aacgtccctggcaccgacttCagcctgggctccgacactgc	10	17	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:45743762C>T	uc002zel.2	+	16	1670	c.1611C>T	c.(1609-1611)TTC>TTT	p.F537F	PFKL_uc002zek.2_Silent_p.F584F|PFKL_uc002zem.2_Silent_p.F124F|PFKL_uc002zen.2_Silent_p.F124F	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	537					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		GCACCGACTTCAGCCTGGGCT	0.652													0	0	0	0.008871	0	13	28										T	45743762	C	T	45743762	2	4	99	1	0	0	0	0	0	0	0	1	11764	825	29	1		1	PFKL	21	45743762	Silent	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	1943499	45743762	2386133	438	30579										
C21orf29	54084	broad.mit.edu	37	chr21	45948467	45948467	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	cgtcactcgaatgttggtttCtgaggggaagaccaggaaga	14	7	2	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:45948467C>G	uc002zfe.1	-	6	857	c.791_splice	c.e6-1	p.E264_splice	C21orf29_uc010gpv.1_Splice_Site_p.E196_splice	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor						cell adhesion	extracellular region	structural molecule activity				0						ATGTTGGTTTCTGAGGGGAAG	0.597													0	0	0	0.006122	0	15	15										G	45948467	C	G	45948467	5	3	99	1	0	0	0	0	0	0	1	0	2124	927	32	1	1247	1	C21orf29	21	45948467	Splice_Site	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	204705	45948467	2181428	439	30580										
VPREB1	7441	broad.mit.edu	37	chr22	22599468	22599468	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	accatgacatcggtgtgtacAgcgtctactggtaccagcag	11	11	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:22599468A>T	uc002zvx.1	+	2	183	c.157A>T	c.(157-159)AGC>TGC	p.S53C	LOC96610_uc011aim.1_Intron	NM_007128	NP_009059	P12018	VPREB_HUMAN	immunoglobulin iota chain precursor	53	Ig-like V-type.|Complementarity-determining-1.				immune response	extracellular region	antigen binding|protein binding				0	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		CGGTGTGTACAGCGTCTACTG	0.627													0	0	0	0.004482	0	6	430										T	22599468	A	T	22599468	3	4	99	1	0	0	0	0	1	0	0	0	17183	188	7	5	163	5	VPREB1	22	22599468	Missense_Mutation	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08		22599468	28705098	440	30581										
GSTT1	2952	broad.mit.edu	37	chr22	24376503	24376503	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgggaagtccttggccttcaGaatgacctcatgggcctcct	11	12	2	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:24376503G>A	uc002zze.3	-	5	696	c.643C>T	c.(643-645)CTG>TTG	p.L215L	GSTT1_uc002zzf.3_RNA|GSTT1_uc010gug.2_RNA|GSTT1_uc011ajl.1_Silent_p.L97L|GSTT1_uc010guh.2_RNA	NM_000853	NP_000844	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	215	GST C-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity			ovary(1)	1					Glutathione(DB00143)	TTGGCCTTCAGAATGACCTCA	0.622									Myelodysplasia_and_Acute_Myeloid_Leukemia_(AML)_Familial				0	0	0	0.013726	0	28	113										A	24376503	G	A	24376503	2	1	99	1	0	0	0	0	0	0	0	1	6845	933	33	1		1	GSTT1	22	24376503	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	1777035	24376503	26928063	441	30582										
PIWIL3	440822	broad.mit.edu	37	chr22	25150040	25150040	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tcctctcggatgtttcctgtCtgggcctgggcagatgttct	12	11	3	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:25150040C>G	uc003abd.1	-	8	1335	c.918G>C	c.(916-918)CAG>CAC	p.Q306H	PIWIL3_uc011ajx.1_Missense_Mutation_p.Q197H|PIWIL3_uc011ajy.1_Missense_Mutation_p.Q197H|PIWIL3_uc010gut.1_Missense_Mutation_p.Q306H	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	306	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TGTTTCCTGTCTGGGCCTGGG	0.388													0	0	0	0.01441	0	52	296										G	25150040	C	G	25150040	3	3	99	1	0	0	0	0	1	0	0	0	11959	912	32	1	1786	1	PIWIL3	22	25150040	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	773537	25150040	26154526	442	30583										
MN1	4330	broad.mit.edu	37	chr22	28195117	28195117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtgcatgctgccgttccacGaagcgcagcggtccactccc	11	16	0	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:28195117G>A	uc003adj.2	-	1	2370	c.1415C>T	c.(1414-1416)TCG>TTG	p.S472L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	472							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GCCGTTCCACGAAGCGCAGCG	0.662			T	ETV6	AML|meningioma								0	0	0	0.003163	0	13	6										A	28195117	G	A	28195117	3	1	99	1	0	0	0	0	1	0	0	0	9673	1059	37	1	2555	1	MN1	22	28195117	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	3045077	28195117	23109449	443	30584										
MOV10L1	54456	broad.mit.edu	37	chr22	50530602	50530602	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aataaagtgtccaatggactGaaagcaatcagggtaaggtt	11	5	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:50530602G>C	uc003bjj.2	+	2	353	c.270G>C	c.(268-270)CTG>CTC	p.L90L	MOV10L1_uc003bjk.3_Silent_p.L90L|MOV10L1_uc011arp.1_Silent_p.L70L|MOV10L1_uc010han.2_Silent_p.L70L	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	90					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CCAATGGACTGAAAGCAATCA	0.418													0	0	0	0.004878	0	29	13										C	50530602	G	C	50530602	2	2	99	1	0	0	0	0	0	0	0	1	9719	1277	45	1		1	MOV10L1	22	50530602	Silent	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	22335485	50530602	773964	444	30585										
PLXNB2	23654	broad.mit.edu	37	chr22	50726223	50726223	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	actcggccttccgggtgcatCtgcaggcgcagggggcggcc	17	14	1	0			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:50726223C>A	uc003bkv.3	-	7	1588	c.1482_splice	c.e7-1	p.R494_splice		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor						regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCGGGTGCATCTGCAGGCGCA	0.706													1	0	3.86212e-05	0.008291	3.9657e-05	8	6										A	50726223	C	A	50726223	5	1	99	1	0	0	0	0	0	0	1	0	12124	927	32	3	4159	3	PLXNB2	22	50726223	Splice_Site	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	195621	50726223	578343	445	30586										
FAM47C	442444	broad.mit.edu	37	chrX	37027156	37027156	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	gagtgtcccatctccgcccaCagcctcccaagactcaggtg	9	17	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647													0	0	0	0.001168	0	5	52										G	37027156	C	G	37027156	3	3	99	1	0	0	0	0	1	0	0	0	5571	479	17	4	675	4	FAM47C	23	37027156	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08		37027156	118243404	446	30587										
FAM47C	442444	broad.mit.edu	37	chrX	37027200	37027200	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	agtctccacctggagcctccAgagactggagtgtcccatct	10	14	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637													0	0	0	0.004672	0	3	49										C	37027200	A	C	37027200	2	2	99	1	0	0	0	0	0	0	0	1	5571	175	7	5		5	FAM47C	23	37027200	Silent	SNP	A	TCGA-G2-A3IE-01A-11D-A20D-08	44	37027200	118243360	447	30588										
PHF16	9767	broad.mit.edu	37	chrX	46913959	46913959	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	aggatgaagaaaatgggctgGtgcagccaaaagaggaaagc	15	5	0	3			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:46913959G>C	uc004dgx.2	+	9	1423	c.1372G>C	c.(1372-1374)GTG>CTG	p.V458L	PHF16_uc004dgy.2_Missense_Mutation_p.V458L	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	458					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						AAATGGGCTGGTGCAGCCAAA	0.433													0	0	0	0.013537	0	11	6										C	46913959	G	C	46913959	3	2	99	1	0	0	0	0	1	0	0	0	11827	1261	44	4	1402	4	PHF16	23	46913959	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	9886759	46913959	108356601	448	30589										
PHF16	9767	broad.mit.edu	37	chrX	46913971	46913971	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atgggctggtgcagccaaaaGaggaaagcattcacactcga	12	9	1	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:46913971G>T	uc004dgx.2	+	9	1435	c.1384G>T	c.(1384-1386)GAG>TAG	p.E462*	PHF16_uc004dgy.2_Nonsense_Mutation_p.E462*	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	462					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						GCAGCCAAAAGAGGAAAGCAT	0.443													1	0	0.00010058	0.013537	0.000102687	10	6										T	46913971	G	T	46913971	4	4	99	1	0	0	0	0	0	1	0	0	11827	943	33	3	1414	3	PHF16	23	46913971	Nonsense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	12	46913971	108356589	449	30590										
PHF8	23133	broad.mit.edu	37	chrX	54048789	54048789	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	atgcccctttgaagatccacGgcgttttttcactaagccag	8	12	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:54048789G>A	uc004dsu.2	-	4	377	c.304C>T	c.(304-306)CGT>TGT	p.R102C	PHF8_uc004dst.2_Missense_Mutation_p.R66C|PHF8_uc004dsw.2_Missense_Mutation_p.R66C|PHF8_uc004dsy.2_Missense_Mutation_p.R66C	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	102	Linker.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						GAAGATCCACGGCGTTTTTTC	0.493													0	0	0	0.01441	0	43	17										A	54048789	G	A	54048789	3	1	99	1	0	0	0	0	1	0	0	0	11840	1116	39	2	3124	2	PHF8	23	54048789	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	7134818	54048789	101221771	450	30591										
ATRX	546	broad.mit.edu	37	chrX	76814231	76814231	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	tgtcataagatggattccaaGaagcgtcgaatataattact	8	6	1	2			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:76814231G>A	uc004ecp.3	-	29	6645	c.6413C>T	c.(6412-6414)TCT>TTT	p.S2138F	ATRX_uc004ecq.3_Missense_Mutation_p.S2100F|ATRX_uc004eco.3_Missense_Mutation_p.S1923F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2138	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGGATTCCAAGAAGCGTCGAA	0.348			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.01441	0	47	22										A	76814231	G	A	76814231	3	1	99	1	0	0	0	0	1	0	0	0	1208	942	33	1	1093	1	ATRX	23	76814231	Missense_Mutation	SNP	G	TCGA-G2-A3IE-01A-11D-A20D-08	22765442	76814231	78456329	451	30592										
ODZ1	10178	broad.mit.edu	37	chrX	123657408	123657408	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	caaccagagtgttctcttctCaggcaggaaaggggatcggt	13	9	2	1			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:123657408C>G	uc004euj.2	-	17	2903	c.2839G>C	c.(2839-2841)GAG>CAG	p.E947Q	ODZ1_uc011muj.1_Missense_Mutation_p.E946Q|ODZ1_uc010nqy.2_Missense_Mutation_p.E947Q	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	947	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTTCTCTTCTCAGGCAGGAAA	0.468													0	0	0	0.01441	0	39	5										G	123657408	C	G	123657408	3	3	99	1	0	0	0	0	1	0	0	0	10834	835	29	1	5423	1	ODZ1	23	123657408	Missense_Mutation	SNP	C	TCGA-G2-A3IE-01A-11D-A20D-08	46843177	123657408	31613152	452	30593										
MAGEC1	9947	broad.mit.edu	37	chrX	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-													0.486725663716814	220	1.23421711418587e-80	3.94348827438104	4.6146124301676	3.45068213100154	0.927277468828765	0.972145733449512	164	ctcactactttcctcagagcCctcctcagggggaggactcc							TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:140994844_140994846delCCT	uc004fbt.2	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)CCTdel	p.P553del	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)								7	344	---	---								-	140994846	CCT	-	140994844	7	5	99	1	0	1	0	1	0	0	0	0	9180	623	22	0	1660	0	MAGEC1	23	140994844	In_Frame_Del	DEL	CCT	TCGA-G2-A3IE-01A-11D-A20D-08	17337436	140994844	14275716	453	30594										
CCNL2	81669	broad.mit.edu	37	chr1	1325663	1325663	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catccagcacctgtgtgcccCcaggcaacaggccccgggct	11	18	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:1325663C>T	uc001afi.2	-	8	985	c.953G>A	c.(952-954)GGG>GAG	p.G318E	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.G96E|CCNL2_uc001afg.1_Missense_Mutation_p.G96E|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	318					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CTGTGTGCCCCCAGGCAACAG	0.572													0	0	0	1	0	22	119										T	1325663	C	T	1325663	3	4	100	1	0	0	0	0	1	0	0	0	2932	623	22	2	625	2	CCNL2	1	1325663	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		1325663	247924958	1	30595										
PLCH2	9651	broad.mit.edu	37	chr1	2435841	2435841	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agacagcgtttcctcctcctCcagcatgtcatccagcgaca	7	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:2435841C>G	uc001aji.1	+	22	3714	c.3440C>G	c.(3439-3441)TCC>TGC	p.S1147C	PLCH2_uc010nyz.1_3'UTR|PLCH2_uc009vle.1_Missense_Mutation_p.S899C|PLCH2_uc001ajj.1_3'UTR|PLCH2_uc001ajk.1_3'UTR|PLCH2_uc001ajl.1_5'UTR	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1147					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TCCTCCTCCTCCAGCATGTCA	0.662													0	0	0	1	0	8	41										G	2435841	C	G	2435841	3	3	100	1	0	0	0	0	1	0	0	0	12038	855	30	1	3526	1	PLCH2	1	2435841	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1110178	2435841	246814780	2	30596										
MMEL1	79258	broad.mit.edu	37	chr1	2541195	2541195	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggatcacgtggcgccgcagcCagcctccgcatgcaaactgg	13	15	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:2541195C>T	uc001ajy.2	-	5	582	c.368G>A	c.(367-369)TGG>TAG	p.W123*	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	123	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GCGCCGCAGCCAGCCTCCGCA	0.607													0	0	0	1	0	18	59										T	2541195	C	T	2541195	4	4	100	1	0	0	0	0	0	1	0	0	9646	595	21	2	2051	2	MMEL1	1	2541195	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	105354	2541195	246709426	3	30597										
KIAA0562	9731	broad.mit.edu	37	chr1	3756216	3756216	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttttagtttcttggcataatCatagcgttccttttggacag	8	7	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:3756216C>G	uc001aky.2	-	7	1050	c.691G>C	c.(691-693)GAT>CAT	p.D231H	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Missense_Mutation_p.D231H	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	231	Potential.					centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TTGGCATAATCATAGCGTTCC	0.358													0	0	0	1	0	84	39										G	3756216	C	G	3756216	3	3	100	1	0	0	0	0	1	0	0	0	8184	826	29	1	2150	1	KIAA0562	1	3756216	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1215021	3756216	245494405	4	30598										
NOL9	79707	broad.mit.edu	37	chr1	6585981	6585981	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tatgtgcctcctcaggttctCttgctccaattttctctgat	6	12	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:6585981C>G	uc001ans.2	-	12	2061	c.2042G>C	c.(2041-2043)AGA>ACA	p.R681T	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	681					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAGGTTCTCTTGCTCCAAT	0.423													0	0	0	1	0	40	128										G	6585981	C	G	6585981	3	3	100	1	0	0	0	0	1	0	0	0	10528	913	32	1	70	1	NOL9	1	6585981	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2829765	6585981	242664640	5	30599										
PIK3CD	5293	broad.mit.edu	37	chr1	9782153	9782153	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcggcaggaggcctacctaGaggccctctcccacctgcag	12	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:9782153G>C	uc001aqb.3	+	17	2384	c.2176G>C	c.(2176-2178)GAG>CAG	p.E726Q	PIK3CD_uc010oaf.1_Missense_Mutation_p.E725Q|PIK3CD_uc001aqe.3_Missense_Mutation_p.E750Q	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	726					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GGCCTACCTAGAGGCCCTCTC	0.637											OREG0013082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	39										C	9782153	G	C	9782153	3	2	100	1	0	0	0	0	1	0	0	0	11915	943	33	1	2234	1	PIK3CD	1	9782153	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3196172	9782153	239468468	6	30600										
VPS13D	55187	broad.mit.edu	37	chr1	12364770	12364770	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccacactgtctgttggccaaGagtccagtagtccaggtaaa	10	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:12364770G>C	uc001atv.2	+	26	6565	c.6424G>C	c.(6424-6426)GAG>CAG	p.E2142Q	VPS13D_uc001atw.2_Missense_Mutation_p.E2142Q|VPS13D_uc001atx.2_Missense_Mutation_p.E1330Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2142					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTTGGCCAAGAGTCCAGTAG	0.522													0	0	0	1	0	39	14										C	12364770	G	C	12364770	3	2	100	1	0	0	0	0	1	0	0	0	17189	943	33	1	6522	1	VPS13D	1	12364770	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2582617	12364770	236885851	7	30601										
SPEN	23013	broad.mit.edu	37	chr1	16260296	16260296	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catctccagctcttcccccaGacacaaaggcctctgatgtt	6	16	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:16260296G>A	uc001axk.1	+	11	7765	c.7561G>A	c.(7561-7563)GAC>AAC	p.D2521N	SPEN_uc010obp.1_Missense_Mutation_p.D2480N	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2521	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCTTCCCCCAGACACAAAGGC	0.562													0	0	0	1	0	70	205										A	16260296	G	A	16260296	3	1	100	1	0	0	0	0	1	0	0	0	15037	942	33	1	7603	1	SPEN	1	16260296	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3895526	16260296	232990325	8	30602										
SPEN	23013	broad.mit.edu	37	chr1	16262749	16262749	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcctgccttcccggaccaaGacagctgctcaggtgagcca	12	15	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:16262749G>A	uc001axk.1	+	11	10218	c.10014G>A	c.(10012-10014)AAG>AAA	p.K3338K	SPEN_uc010obp.1_Silent_p.K3297K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3338	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCGGACCAAGACAGCTGCTC	0.592													0	0	0	1	0	29	31										A	16262749	G	A	16262749	2	1	100	1	0	0	0	0	0	0	0	1	15037	933	33	1		1	SPEN	1	16262749	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2453	16262749	232987872	9	30603										
NECAP2	55707	broad.mit.edu	37	chr1	16767292	16767292	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tacgagtcggtgctctgtgtCaagcctgacgtccacgtcta	11	12	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:16767292C>T	uc001ayo.2	+	1	126	c.36C>T	c.(34-36)GTC>GTT	p.V12V	NECAP2_uc001ayp.3_RNA|NECAP2_uc010ocd.1_Intron|NECAP2_uc001ayq.2_Silent_p.V12V	NM_018090	NP_060560	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2 isoform 1	12					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTCTGTGTCAAGCCTGACG	0.627											OREG0013136	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	49										T	16767292	C	T	16767292	2	4	100	1	0	0	0	0	0	0	0	1	10308	813	29	1		1	NECAP2	1	16767292	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	504543	16767292	232483329	10	30604										
PADI6	353238	broad.mit.edu	37	chr1	17699682	17699682	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctgtctgatcccacgtacgCcacagtgaagatgacatcgc	9	14	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:17699682C>A	uc001bak.1	+	2	248	c.248C>A	c.(247-249)GCC>GAC	p.A83D		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	75					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CCCACGTACGCCACAGTGAAG	0.597													1	0	3.45872e-05	1	3.56746e-05	17	18										A	17699682	C	A	17699682	3	1	100	1	0	0	0	0	1	0	0	0	11381	739	26	4	254	4	PADI6	1	17699682	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	932390	17699682	231550939	11	30605										
ARHGEF10L	55160	broad.mit.edu	37	chr1	18021748	18021748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgtcctgctgcccgtgcctCggctggaaggcatccccaag	12	16	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:18021748C>T	uc001ban.2	+	28	3439	c.3280C>T	c.(3280-3282)CGG>TGG	p.R1094W	ARHGEF10L_uc001bao.2_Missense_Mutation_p.R1055W|ARHGEF10L_uc001bap.2_Missense_Mutation_p.R1050W|ARHGEF10L_uc001baq.2_Missense_Mutation_p.R855W|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.R867W|ARHGEF10L_uc001bar.2_Missense_Mutation_p.R797W|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.R118W	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1094					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GCCCGTGCCTCGGCTGGAAGG	0.647													0	0	0	1	0	13	49										T	18021748	C	T	18021748	3	4	100	1	0	0	0	0	1	0	0	0	895	875	31	1	3386	1	ARHGEF10L	1	18021748	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	322066	18021748	231228873	12	30606										
UBR4	23352	broad.mit.edu	37	chr1	19436596	19436596	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcttggcccagtaccttgttCttcttgctagtgggagcagg	13	10	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:19436596C>A	uc001bbi.2	-	81	12103	c.12099G>T	c.(12097-12099)AAG>AAT	p.K4033N		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4033					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTACCTTGTTCTTCTTGCTAG	0.542													1	0	1.61788e-16	1	1.78652e-16	31	87										A	19436596	C	A	19436596	3	1	100	1	0	0	0	0	1	0	0	0	16901	912	32	3	3556	3	UBR4	1	19436596	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1414848	19436596	229814025	13	30607										
CELA3B	23436	broad.mit.edu	37	chr1	22303559	22303559	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccggctgctcagttccctCctccttgtggccgttggtaa	10	15	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:22303559C>T	uc001bfk.2	+	1	142	c.27C>T	c.(25-27)CTC>CTT	p.L9L	CELA3B_uc009vqf.2_Silent_p.L8L	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	9					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						TCAGTTCCCTCCTCCTTGTGG	0.527													0	0	0	1	0	59	196										T	22303559	C	T	22303559	2	4	100	1	0	0	0	0	0	0	0	1	3214	842	30	1		1	CELA3B	1	22303559	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2866963	22303559	226947062	14	30608										
ZBTB40	9923	broad.mit.edu	37	chr1	22852749	22852749	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcaggtgatcactttggagGagacccagcttgccgggtcg	15	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:22852749G>C	uc001bft.2	+	19	4091	c.3580G>C	c.(3580-3582)GAG>CAG	p.E1194Q	ZBTB40_uc001bfu.2_Missense_Mutation_p.E1194Q|ZBTB40_uc009vqi.1_Missense_Mutation_p.E1082Q	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1194					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CACTTTGGAGGAGACCCAGCT	0.587													0	0	0	1	0	19	78										C	22852749	G	C	22852749	3	2	100	1	0	0	0	0	1	0	0	0	17539	1175	41	1	3646	1	ZBTB40	1	22852749	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	549190	22852749	226397872	15	30609										
MYOM3	127294	broad.mit.edu	37	chr1	24421367	24421367	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcggaaccactggatgctctCagcatctaacacatcttccg	7	14	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:24421367C>T	uc001bin.3	-	9	1067	c.904G>A	c.(904-906)GAG>AAG	p.E302K	MYOM3_uc001bim.3_5'UTR|MYOM3_uc001bio.2_Missense_Mutation_p.E302K|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	302	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGGATGCTCTCAGCATCTAAC	0.577													0	0	0	1	0	9	30										T	24421367	C	T	24421367	3	4	100	1	0	0	0	0	1	0	0	0	10093	835	29	1	3525	1	MYOM3	1	24421367	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1568618	24421367	224829254	16	30610										
LIN28A	79727	broad.mit.edu	37	chr1	26752886	26752886	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtgcacagggaaagccaacCtactttcgagaggaagaaga	12	8	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:26752886C>G	uc001bmj.2	+	4	681	c.567C>G	c.(565-567)ACC>ACG	p.T189T	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	189					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						GAAAGCCAACCTACTTTCGAG	0.557													0	0	0	1	0	18	55										G	26752886	C	G	26752886	2	3	100	1	0	0	0	0	0	0	0	1	8805	668	24	4		4	LIN28A	1	26752886	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2331519	26752886	222497735	17	30611										
PIGV	55650	broad.mit.edu	37	chr1	27121497	27121497	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaatactatgagctcaagcaGgtgcccaattttctactggc	8	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:27121497G>C	uc001bmz.2	+	3	1303	c.972G>C	c.(970-972)CAG>CAC	p.Q324H	PIGV_uc001bmy.2_Missense_Mutation_p.Q89H|PIGV_uc009vso.2_Missense_Mutation_p.Q324H|PIGV_uc010ofg.1_Missense_Mutation_p.Q89H|PIGV_uc001bna.2_Missense_Mutation_p.Q324H	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	324	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		AGCTCAAGCAGGTGCCCAATT	0.488													0	0	0	1	0	45	202										C	27121497	G	C	27121497	3	2	100	1	0	0	0	0	1	0	0	0	11901	991	35	4	978	4	PIGV	1	27121497	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	368611	27121497	222129124	18	30612										
COL16A1	1307	broad.mit.edu	37	chr1	32140871	32140871	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtacccaccagttctgcagtGagcccaggctgtcctggcaa	11	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:32140871G>A	uc001btk.1	-	43	3179	c.2814C>T	c.(2812-2814)CTC>CTT	p.L938L	COL16A1_uc001btj.1_Silent_p.L751L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	938	Triple-helical region 4 (COL4) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GTTCTGCAGTGAGCCCAGGCT	0.617													0	0	0	1	0	11	15										A	32140871	G	A	32140871	2	1	100	1	0	0	0	0	0	0	0	1	3673	1277	45	1		1	COL16A1	1	32140871	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5019374	32140871	217109750	19	30613										
KIAA1522	57648	broad.mit.edu	37	chr1	33237530	33237530	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accactgcgaagggccctgtCagggcgggccagcccagtgc	15	15	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:33237530C>G	uc001bvv.2	+	6	2709	c.2573C>G	c.(2572-2574)TCA>TGA	p.S858*	KIAA1522_uc001bvu.1_Nonsense_Mutation_p.S917*|KIAA1522_uc010ohm.1_Nonsense_Mutation_p.S869*|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	858	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGGCCCTGTCAGGGCGGGCC	0.706													0	0	0	1	0	4	14										G	33237530	C	G	33237530	4	3	100	1	0	0	0	0	0	1	0	0	8238	838	29	1	2772	1	KIAA1522	1	33237530	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1096659	33237530	216013091	20	30614										
CSF3R	1441	broad.mit.edu	37	chr1	36932897	36932897	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggtctgggacacttggccaGaggggattcttcctgctgga	16	9	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:36932897G>T	uc001caw.1	-	16	2152	c.1974C>A	c.(1972-1974)CTC>CTA	p.L658L	MRPS15_uc001cas.2_5'Flank|CSF3R_uc001cat.1_Silent_p.L220L|CSF3R_uc009vvc.1_Silent_p.L187L|CSF3R_uc001cau.1_Silent_p.L58L|CSF3R_uc001cav.1_Silent_p.L658L|CSF3R_uc001cax.1_Silent_p.L658L|CSF3R_uc001cay.1_Missense_Mutation_p.S627Y	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	658	Box 1 motif.|Cytoplasmic (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CACTTGGCCAGAGGGGATTCT	0.587													1	0	2.47872e-24	1	2.78548e-24	38	35										T	36932897	G	T	36932897	2	4	100	1	0	0	0	0	0	0	0	1	3937	942	33	3		3	CSF3R	1	36932897	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3695367	36932897	212317724	21	30615										
EPHA10	284656	broad.mit.edu	37	chr1	38192853	38192853	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cactacggtgacgacaatggCggggctctggtccctggacc	14	13	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:38192853C>T	uc009vvi.2	-	8	1779	c.1693G>A	c.(1693-1695)GCC>ACC	p.A565T	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	565	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACGACAATGGCGGGGCTCTGG	0.642													0	0	0	1	0	7	22										T	38192853	C	T	38192853	3	4	100	1	0	0	0	0	1	0	0	0	5166	768	27	2	1373	2	EPHA10	1	38192853	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1259956	38192853	211057768	22	30616										
EPHA10	284656	broad.mit.edu	37	chr1	38227612	38227612	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagtcacggagtgtgaactgCagttccacgaagatgcgctg	13	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:38227612C>T	uc009vvi.2	-	3	401	c.315G>A	c.(313-315)CTG>CTA	p.L105L	EPHA10_uc001cbw.3_Silent_p.L105L	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	105	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTGTGAACTGCAGTTCCACGA	0.617													0	0	0	1	0	71	57										T	38227612	C	T	38227612	2	4	100	1	0	0	0	0	0	0	0	1	5166	697	25	2		2	EPHA10	1	38227612	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	34759	38227612	211023009	23	30617										
ZNF642	339559	broad.mit.edu	37	chr1	40961190	40961190	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atcacttaatcagcatcataGaactcacactggggagaaac	7	10	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:40961190G>A	uc001cfo.2	+	6	1334	c.1040G>A	c.(1039-1041)AGA>AAA	p.R347K	ZNF642_uc009vwb.2_Missense_Mutation_p.R347K|ZNF642_uc010ojk.1_Missense_Mutation_p.R348K	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	347	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			CAGCATCATAGAACTCACACT	0.433													0	0	0	1	0	25	71										A	40961190	G	A	40961190	3	1	100	1	0	0	0	0	1	0	0	0	18055	942	33	1	1058	1	ZNF642	1	40961190	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2733578	40961190	208289431	24	30618										
EBNA1BP2	10969	broad.mit.edu	37	chr1	43630326	43630326	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcacttacatttgaccctttCttgccaggcctcttgaggcc	7	14	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:43630326C>G	uc001cin.2	-	8	1055	c.858G>C	c.(856-858)AAG>AAC	p.K286N	EBNA1BP2_uc001cio.2_Missense_Mutation_p.K341N|EBNA1BP2_uc001cim.2_Missense_Mutation_p.K181N|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.K341N	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	286					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTGACCCTTTCTTGCCAGGCC	0.572													0	0	0	1	0	33	20										G	43630326	C	G	43630326	3	3	100	1	0	0	0	0	1	0	0	0	4885	912	32	1	70	1	EBNA1BP2	1	43630326	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2669136	43630326	205620295	25	30619										
ARTN	9048	broad.mit.edu	37	chr1	44401357	44401357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggacttggaggcctctccaCgctgtcccactgcccctggc	11	17	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:44401357C>T	uc001cks.2	+	3	811	c.29C>T	c.(28-30)ACG>ATG	p.T10M	ARTN_uc001ckv.2_Missense_Mutation_p.T10M|ARTN_uc001ckt.2_Missense_Mutation_p.T10M|ARTN_uc001cku.2_Missense_Mutation_p.T10M|ARTN_uc001ckw.2_5'Flank	NM_057091	NP_476432	Q5T4W7	ARTN_HUMAN	neurotrophic factor artemin isoform 1 precursor	10					axon guidance|neuroblast proliferation|signal transduction	extracellular region	growth factor activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				GGCCTCTCCACGCTGTCCCAC	0.597													0	0	0	1	0	7	13										T	44401357	C	T	44401357	3	4	100	1	0	0	0	0	1	0	0	0	1001	536	19	2	31	2	ARTN	1	44401357	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	771031	44401357	204849264	26	30620										
IPO13	9670	broad.mit.edu	37	chr1	44422329	44422329	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctggccactatcctgtcaatGagaccaccagctccctaacc	6	17	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:44422329G>T	uc001ckx.2	+	4	1855	c.1060G>T	c.(1060-1062)GAG>TAG	p.E354*		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	354	HEAT 5.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TCCTGTCAATGAGACCACCAG	0.547													1	0	1.49673e-21	1	1.67272e-21	39	69										T	44422329	G	T	44422329	4	4	100	1	0	0	0	0	0	1	0	0	7794	1291	45	3	1074	3	IPO13	1	44422329	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	20972	44422329	204828292	27	30621										
IPO13	9670	broad.mit.edu	37	chr1	44424502	44424502	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cactggacatcagtcatcatGaggatgatcatgaaggccct	10	10	4	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:44424502G>A	uc001ckx.2	+	11	2764	c.1969G>A	c.(1969-1971)GAG>AAG	p.E657K		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	657	HEAT 11.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CAGTCATCATGAGGATGATCA	0.547													0	0	0	1	0	24	39										A	44424502	G	A	44424502	3	1	100	1	0	0	0	0	1	0	0	0	7794	1291	45	1	2011	1	IPO13	1	44424502	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2173	44424502	204826119	28	30622										
STIL	6491	broad.mit.edu	37	chr1	47717130	47717130	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccccacagattcacagttaGaacaattaattatttcatgg	5	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:47717130G>A	uc001crc.1	-	17	3697	c.3542C>T	c.(3541-3543)TCT>TTT	p.S1181F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.S1135F|STIL_uc010omo.1_Missense_Mutation_p.S1164F|STIL_uc001crd.1_Missense_Mutation_p.S1182F|STIL_uc001cre.1_Missense_Mutation_p.S1181F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1181					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTCACAGTTAGAACAATTAAT	0.373													0	0	0	1	0	36	66										A	47717130	G	A	47717130	3	1	100	1	0	0	0	0	1	0	0	0	15281	942	33	1	325	1	STIL	1	47717130	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3292628	47717130	201533491	29	30623										
FAF1	11124	broad.mit.edu	37	chr1	50956338	50956338	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctctctcgtgagcttccctCtgttgataaaacagaaaagg	8	10	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:50956338C>G	uc009vyx.1	-	18	1639	c.1576_splice	c.e18-1	p.R526_splice	FAF1_uc009vyw.1_Splice_Site|FAF1_uc001cse.1_Splice_Site_p.R526_splice|FAF1_uc010onc.1_Splice_Site_p.R284_splice	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		GAGCTTCCCTCTGTTGATAAA	0.308													0	0	0	1	0	34	74										G	50956338	C	G	50956338	5	3	100	1	0	0	0	0	0	0	1	0	5369	927	32	1	389	1	FAF1	1	50956338	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3239208	50956338	198294283	30	30624										
C1orf168	199920	broad.mit.edu	37	chr1	57192183	57192183	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcccacctttctgattcttCagcaccgtttttctcttttt	3	13	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:57192183C>G	uc001cym.3	-	16	2273	c.1867G>C	c.(1867-1869)GAA>CAA	p.E623Q	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	623										ovary(3)|skin(2)	5						TCTGATTCTTCAGCACCGTTT	0.299													0	0	0	1	0	20	67										G	57192183	C	G	57192183	3	3	100	1	0	0	0	0	1	0	0	0	2012	835	29	1	339	1	C1orf168	1	57192183	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6235845	57192183	192058438	31	30625										
TACSTD2	4070	broad.mit.edu	37	chr1	59042168	59042168	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctcgaagtagtaggcggcatCgccgatatccacgtcaccgg	12	13	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:59042168C>A	uc001cyz.3	-	1	999	c.661G>T	c.(661-663)GAT>TAT	p.D221Y		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	221	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					TAGGCGGCATCGCCGATATCC	0.652													1	0	8.12818e-05	1	8.34986e-05	7	14										A	59042168	C	A	59042168	3	1	100	1	0	0	0	0	1	0	0	0	15505	884	31	3	314	3	TACSTD2	1	59042168	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1849985	59042168	190208453	32	30626										
JAK1	3716	broad.mit.edu	37	chr1	65316594	65316594	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caccagcaggttggagatttCtgtggaagagattgggggag	17	5	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:65316594C>T	uc001dbu.1	-	12	1898	c.1649_splice	c.e12-1	p.E550_splice	JAK1_uc009wam.1_Splice_Site_p.E538_splice	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1						interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TTGGAGATTTCTGTGGAAGAG	0.597			Mis		ALL								0	0	0	1	0	5	14										T	65316594	C	T	65316594	5	4	100	1	0	0	0	0	0	0	1	0	7937	927	32	1	1872	1	JAK1	1	65316594	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6274426	65316594	183934027	33	30627										
SLC35D1	23169	broad.mit.edu	37	chr1	67518490	67518490	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgtcaaggtcaggaaacttGactactctgagcgcctttcc	9	12	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:67518490G>C	uc001ddk.2	-	3	672	c.288C>G	c.(286-288)GTC>GTG	p.V96V	SLC35D1_uc010oph.1_Silent_p.V17V	NM_015139	NP_055954	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-glucuronic	96					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity				0					Lorazepam(DB00186)	CAGGAAACTTGACTACTCTGA	0.393													0	0	0	1	0	62	44										C	67518490	G	C	67518490	2	2	100	1	0	0	0	0	0	0	0	1	14581	1277	45	1		1	SLC35D1	1	67518490	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2201896	67518490	181732131	34	30628										
CRYZ	1429	broad.mit.edu	37	chr1	75188928	75188928	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tatgtctccacggggttgacAccacatgcatggaccttgat	10	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:75188928A>T	uc001dgk.2	-	4	643	c.138T>A	c.(136-138)GGT>GGA	p.G46G	CRYZ_uc001dgj.2_Silent_p.G46G|CRYZ_uc001dgl.2_Silent_p.G46G|CRYZ_uc001dgm.2_5'UTR	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	46					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	CGGGGTTGACACCACATGCAT	0.378													0	0	0	1	0	64	38										T	75188928	A	T	75188928	2	4	100	1	0	0	0	0	0	0	0	1	3922	146	6	5		5	CRYZ	1	75188928	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	7670438	75188928	174061693	35	30629										
LMO4	8543	broad.mit.edu	37	chr1	87805743	87805743	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctttcagtgttttacatgctCtacctgccggaatcgcctgg	9	12	2	0	rs139269304		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:87805743C>T	uc001dmi.2	+	4	1127	c.347C>T	c.(346-348)TCT>TTT	p.S116F	LMO4_uc001dmj.2_Missense_Mutation_p.S116F	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	116	LIM zinc-binding 2.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		TTTACATGCTCTACCTGCCGG	0.403													0	0	0	1	0	55	45										T	87805743	C	T	87805743	3	4	100	1	0	0	0	0	1	0	0	0	8854	913	32	1	357	1	LMO4	1	87805743	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	12616815	87805743	161444878	36	30630										
RPAP2	79871	broad.mit.edu	37	chr1	92767046	92767046	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attttaggaaagctgaactaGaagcagctgtgagaaagaag	12	4	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:92767046G>C	uc001dot.2	+	3	242	c.133G>C	c.(133-135)GAA>CAA	p.E45Q	RPAP2_uc009wdh.2_RNA|GLMN_uc001dor.2_5'Flank|GLMN_uc009wdg.2_5'Flank|GLMN_uc001dos.2_5'Flank	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	45	Potential.					integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		AGCTGAACTAGAAGCAGCTGT	0.328													0	0	0	1	0	17	24										C	92767046	G	C	92767046	3	2	100	1	0	0	0	0	1	0	0	0	13542	943	33	1	143	1	RPAP2	1	92767046	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4961303	92767046	156483575	37	30631										
ABCA4	24	broad.mit.edu	37	chr1	94473258	94473258	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgagcatcttgaatgtggtTgttttgccggcaccattcac	11	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:94473258T>G	uc001dqh.2	-	43	6041	c.5937A>C	c.(5935-5937)ACA>ACC	p.T1979T	ABCA4_uc001dqi.1_Silent_p.T98T	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1979	ABC transporter 2.|Cytoplasmic.|ATP 2 (Potential).				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TGAATGTGGTTGTTTTGCCGG	0.547													0	0	0	1	0	20	44										G	94473258	T	G	94473258	2	3	100	1	0	0	0	0	0	0	0	1	34	1799	63	5		5	ABCA4	1	94473258	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	1706212	94473258	154777363	38	30632										
ABCD3	5825	broad.mit.edu	37	chr1	94941201	94941201	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attataaaatggggaatctgGacaacagaatagctaatcca	8	6	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:94941201G>C	uc001dqn.3	+	7	637	c.535G>C	c.(535-537)GAC>CAC	p.D179H	ABCD3_uc001dqm.3_Missense_Mutation_p.D179H|ABCD3_uc010oto.1_Missense_Mutation_p.D203H|ABCD3_uc010otp.1_Missense_Mutation_p.D106H|ABCD3_uc009wdr.2_Missense_Mutation_p.D179H	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	179	ABC transmembrane type-1.|Interaction with PEX19.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GGGGAATCTGGACAACAGAAT	0.303													0	0	0	1	0	16	22										C	94941201	G	C	94941201	3	2	100	1	0	0	0	0	1	0	0	0	62	1174	41	1	561	1	ABCD3	1	94941201	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	467943	94941201	154309420	39	30633										
COL11A1	1301	broad.mit.edu	37	chr1	103488306	103488306	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtatcaacttacgcttgtttCtgtaatatcagtttctgctg	7	8	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:103488306C>T	uc001dul.2	-	8	1555	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E425K|COL11A1_uc001dun.2_Missense_Mutation_p.E374K|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	413	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.F413V(1)		ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACGCTTGTTTCTGTAATATCA	0.328													0	0	0	1	0	26	45										T	103488306	C	T	103488306	3	4	100	1	0	0	0	0	1	0	0	0	3667	922	32	1	4423	1	COL11A1	1	103488306	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	8547105	103488306	145762315	40	30634										
KIAA1324	57535	broad.mit.edu	37	chr1	109715160	109715160	+	Missense_Mutation	SNP	G	G	T													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgactccaggtggatgaaGaccacagagaaaggatggga							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:109715160G>T	uc001dwq.2	+	6	802	c.666G>T	c.(664-666)AAG>AAT	p.K222N	KIAA1324_uc009wex.1_Missense_Mutation_p.K222N|KIAA1324_uc009wey.2_Missense_Mutation_p.K222N|KIAA1324_uc010ovg.1_Missense_Mutation_p.K120N	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	222	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GGTGGATGAAGACCACAGAGA	0.502													1	0	0.0477658	1	0.0479071	8	30										T	109715160	G	T	109715160	3	4	100	1	0	0	0	0	1	0	0	0	8223	933	33	3	684	3	KIAA1324	1	109715160	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	6226854	109715160	139535461	41	30635	154	2								
KIAA1324	57535	broad.mit.edu	37	chr1	109715167	109715167	+	Missense_Mutation	SNP	G	G	A													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaggtggatgaagaccacaGagaaaggatgggaattccac							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:109715167G>A	uc001dwq.2	+	6	809	c.673G>A	c.(673-675)GAG>AAG	p.E225K	KIAA1324_uc009wex.1_Missense_Mutation_p.E225K|KIAA1324_uc009wey.2_Missense_Mutation_p.E225K|KIAA1324_uc010ovg.1_Missense_Mutation_p.E123K	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	225	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GAAGACCACAGAGAAAGGATG	0.512													0	0	0	1	0	9	30										A	109715167	G	A	109715167	3	1	100	1	0	0	0	0	1	0	0	0	8223	943	33	1	691	1	KIAA1324	1	109715167	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7	109715167	139535454	42	30636	154	2								
AMPD2	271	broad.mit.edu	37	chr1	110163738	110163738	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggaaggggttggatgtggcaGagccaggccccagccggtgc	19	10	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:110163738G>A	uc009wfh.1	+	2	645	c.103G>A	c.(103-105)GAG>AAG	p.E35K	AMPD2_uc009wfg.1_Intron|AMPD2_uc001dyb.1_Intron|AMPD2_uc001dyc.1_Missense_Mutation_p.E35K|AMPD2_uc010ovr.1_Silent_p.Q3Q|AMPD2_uc010ovs.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	35					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGATGTGGCAGAGCCAGGCCC	0.687													0	0	0	1	0	4	4										A	110163738	G	A	110163738	3	1	100	1	0	0	0	0	1	0	0	0	586	943	33	1	119	1	AMPD2	1	110163738	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	448571	110163738	139086883	43	30637										
AMPD2	271	broad.mit.edu	37	chr1	110169425	110169425	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgggagaagtacatggccctGtccctgcagagcttctgccc	12	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:110169425G>C	uc009wfh.1	+	7	1313	c.771G>C	c.(769-771)CTG>CTC	p.L257L	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.L176L|AMPD2_uc001dyc.1_Silent_p.L257L|AMPD2_uc010ovr.1_Silent_p.L182L|AMPD2_uc010ovs.1_Silent_p.L139L|AMPD2_uc001dyd.1_Silent_p.L138L|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	257					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		ACATGGCCCTGTCCCTGCAGA	0.622													0	0	0	1	0	10	46										C	110169425	G	C	110169425	2	2	100	1	0	0	0	0	0	0	0	1	586	1364	48	4		4	AMPD2	1	110169425	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5687	110169425	139081196	44	30638										
PTPN22	26191	broad.mit.edu	37	chr1	114402061	114402061	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggttttgtctgccttgtactTggtagattgccttttcagct	10	8	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:114402061T>C	uc001eds.2	-	2	239	c.109A>G	c.(109-111)AAG>GAG	p.K37E	uc001edv.1_Intron|PTPN22_uc009wgq.2_Missense_Mutation_p.K37E|PTPN22_uc010owo.1_5'UTR|PTPN22_uc001edt.2_Missense_Mutation_p.K37E|PTPN22_uc009wgr.2_Missense_Mutation_p.K37E|PTPN22_uc009wgs.2_Missense_Mutation_p.K37E|PTPN22_uc001edu.2_Missense_Mutation_p.K37E	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	37	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTTGTACTTGGTAGATTGC	0.363													0	0	0	1	0	65	37										C	114402061	T	C	114402061	3	2	100	1	0	0	0	0	1	0	0	0	12787	1821	63	5	2417	5	PTPN22	1	114402061	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	4232636	114402061	134848560	45	30639										
TTF2	8458	broad.mit.edu	37	chr1	117617798	117617798	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcaagagaagaagcaagaaGagggagcagagattcagtgt	14	4	2	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:117617798G>C	uc001egy.2	+	5	612	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	TTF2_uc001egx.1_Missense_Mutation_p.E198Q	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	198					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GAAGCAAGAAGAGGGAGCAGA	0.418													0	0	0	1	0	18	54										C	117617798	G	C	117617798	3	2	100	1	0	0	0	0	1	0	0	0	16716	943	33	1	610	1	TTF2	1	117617798	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3215737	117617798	131632823	46	30640										
FAM46C	54855	broad.mit.edu	37	chr1	118166265	118166265	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcgggacttcaggcccacaGaccaggaagaaatcaaaact	10	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:118166265G>C	uc001ehe.2	+	2	974	c.775G>C	c.(775-777)GAC>CAC	p.D259H		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	259											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CAGGCCCACAGACCAGGAAGA	0.512										Multiple Myeloma(3;1.13e-06)			0	0	0	1	0	16	52										C	118166265	G	C	118166265	3	2	100	1	0	0	0	0	1	0	0	0	5567	942	33	1	777	1	FAM46C	1	118166265	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	548467	118166265	131084356	47	30641										
NOTCH2	4853	broad.mit.edu	37	chr1	120539792	120539792	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgaggcaggtgccaccatgCtggcagtgtcctggaatgtc	14	10	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:120539792C>T	uc001eik.2	-	4	835	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	NOTCH2_uc001eil.2_Silent_p.Q193Q|NOTCH2_uc001eim.3_Silent_p.Q110Q	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	193	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCCACCATGCTGGCAGTGTC	0.567			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	1	0	13	103										T	120539792	C	T	120539792	2	4	100	1	0	0	0	0	0	0	0	1	10548	796	28	2		2	NOTCH2	1	120539792	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2373527	120539792	128710829	48	30642										
NOTCH2	4853	broad.mit.edu	37	chr1	120539834	120539834	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cactcattgacatcagtctcAcatttctgccctgtgaagcc	6	14	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:120539834A>G	uc001eik.2	-	4	793	c.537T>C	c.(535-537)TGT>TGC	p.C179C	NOTCH2_uc001eil.2_Silent_p.C179C|NOTCH2_uc001eim.3_Silent_p.C96C	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	179	Extracellular (Potential).|EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCAGTCTCACATTTCTGCC	0.552			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	1	0	15	116										G	120539834	A	G	120539834	2	3	100	1	0	0	0	0	0	0	0	1	10548	157	6	5		5	NOTCH2	1	120539834	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	42	120539834	128710787	49	30643										
PRKAB2	5565	broad.mit.edu	37	chr1	146639436	146639436	+	Missense_Mutation	SNP	G	G	T													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagaccagcggataacagtgGgccgggcctgctgtgtgggc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:146639436G>T	uc001epe.2	-	3	378	c.233C>A	c.(232-234)CCC>CAC	p.P78H	PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_Missense_Mutation_p.P78H	NM_005399	NP_005390	O43741	AAKB2_HUMAN	AMP-activated protein kinase beta 2	78					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	GATAACAGTGGGCCGGGCCTG	0.527													1	0	2.48941e-46	1	2.82244e-46	92	166										T	146639436	G	T	146639436	3	4	100	1	0	0	0	0	1	0	0	0	12496	1232	43	4	609	4	PRKAB2	1	146639436	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	26099602	146639436	102611185	50	30644	155	2								
PRKAB2	5565	broad.mit.edu	37	chr1	146639438	146639438	+	Silent	SNP	C	C	T													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaccagcggataacagtgggCcgggcctgctgtgtgggctt							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:146639438C>T	uc001epe.2	-	3	376	c.231G>A	c.(229-231)CGG>CGA	p.R77R	PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_Silent_p.R77R	NM_005399	NP_005390	O43741	AAKB2_HUMAN	AMP-activated protein kinase beta 2	77					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	TAACAGTGGGCCGGGCCTGCT	0.522													0	0	0	1	0	90	161										T	146639438	C	T	146639438	2	4	100	1	0	0	0	0	0	0	0	1	12496	726	26	2		2	PRKAB2	1	146639438	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2	146639438	102611183	51	30645	155	2								
PLEKHO1	51177	broad.mit.edu	37	chr1	150129184	150129184	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctcaactctgccatcacccGagccaagaaccgtatcttgg	7	16	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:150129184G>A	uc001ett.2	+	4	676	c.398G>A	c.(397-399)CGA>CAA	p.R133Q	PLEKHO1_uc001etr.2_5'UTR|PLEKHO1_uc001ets.2_5'UTR|PLEKHO1_uc001etu.2_5'UTR	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	133	Interaction with capping proteins (CPs).			R->E: No effect on binding to capping proteins; when associated with E-135.|R->A: No effect on binding to capping proteins and loss of phospholipid binding; when associated with A-135 and A-137.		cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCATCACCCGAGCCAAGAAC	0.587													0	0	0	1	0	11	77										A	150129184	G	A	150129184	3	1	100	1	0	0	0	0	1	0	0	0	12084	1058	37	1	412	1	PLEKHO1	1	150129184	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3489746	150129184	99121437	52	30646										
APH1A	51107	broad.mit.edu	37	chr1	150240428	150240428	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagcagcaccaaaaatcagGaggccgtactggagccgggc	13	12	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:150240428G>A	uc001ety.1	-	2	535	c.213C>T	c.(211-213)CTC>CTT	p.L71L	APH1A_uc010pbx.1_Intron|APH1A_uc001etz.1_Silent_p.L71L|APH1A_uc001eua.1_Silent_p.L71L|APH1A_uc010pby.1_Intron|APH1A_uc001eub.1_Intron|APH1A_uc010pbz.1_Intron	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	71	Helical; Name=3; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAAAATCAGGAGGCCGTACT	0.557													0	0	0	1	0	20	115										A	150240428	G	A	150240428	2	1	100	1	0	0	0	0	0	0	0	1	771	1161	41	1		1	APH1A	1	150240428	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	111244	150240428	99010193	53	30647										
HORMAD1	84072	broad.mit.edu	37	chr1	150689625	150689625	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgtattaccatctagatatCttgttccataagcgcattct	5	9	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:150689625C>G	uc001evk.1	-	3	273	c.167G>C	c.(166-168)AGA>ACA	p.R56T	HORMAD1_uc001evl.1_Missense_Mutation_p.R56T|HORMAD1_uc001evm.1_Missense_Mutation_p.K6N	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	56	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			ATCTAGATATCTTGTTCCATA	0.318													0	0	0	1	0	25	127										G	150689625	C	G	150689625	3	3	100	1	0	0	0	0	1	0	0	0	7286	913	32	1	1069	1	HORMAD1	1	150689625	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	449197	150689625	98560996	54	30648										
SEMA6C	10500	broad.mit.edu	37	chr1	151108989	151108989	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccagactcctctgctccttGaacttgccctcaaacccacg	5	18	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:151108989G>C	uc001ewu.2	-	12	1341	c.1041C>G	c.(1039-1041)TTC>TTG	p.F347L	SEMA6C_uc001ewv.2_Missense_Mutation_p.F347L|SEMA6C_uc001eww.2_Missense_Mutation_p.F307L|SEMA6C_uc010pcq.1_Missense_Mutation_p.F347L	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	347	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTGCTCCTTGAACTTGCCCT	0.567													0	0	0	1	0	43	204										C	151108989	G	C	151108989	3	2	100	1	0	0	0	0	1	0	0	0	14041	1281	45	1	1883	1	SEMA6C	1	151108989	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	419364	151108989	98141632	55	30649										
FLG	2312	broad.mit.edu	37	chr1	152279938	152279938	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaattgctcgtagtgggatCcctgccttcctccactgctt	8	15	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:152279938C>G	uc001ezu.1	-	3	7460	c.7424G>C	c.(7423-7425)GGA>GCA	p.G2475A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2475	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTAGTGGGATCCCTGCCTTCC	0.577									Ichthyosis				0	0	0	1	0	136	337										G	152279938	C	G	152279938	3	3	100	1	0	0	0	0	1	0	0	0	5922	855	30	1	4765	1	FLG	1	152279938	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1170949	152279938	96970683	56	30650										
FLG	2312	broad.mit.edu	37	chr1	152281452	152281452	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gattgtctggagctgtctgcAgagtgcccgtgaccggctct	14	11	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:152281452A>T	uc001ezu.1	-	3	5946	c.5910T>A	c.(5908-5910)TCT>TCA	p.S1970S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1970	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTCTGCAGAGTGCCCGT	0.557									Ichthyosis				0	0	0	1	0	106	569										T	152281452	A	T	152281452	2	4	100	1	0	0	0	0	0	0	0	1	5922	175	7	5		5	FLG	1	152281452	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1514	152281452	96969169	57	30651										
FLG	2312	broad.mit.edu	37	chr1	152283396	152283396	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gattgtctggagctgtctgcAgagtgcccgtgactggctct	14	10	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:152283396A>T	uc001ezu.1	-	3	4002	c.3966T>A	c.(3964-3966)TCT>TCA	p.S1322S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1322	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTCTGCAGAGTGCCCGT	0.358									Ichthyosis				0	0	0	1	0	14	302										T	152283396	A	T	152283396	2	4	100	1	0	0	0	0	0	0	0	1	5922	175	7	5		5	FLG	1	152283396	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1944	152283396	96967225	58	30652										
S100A8	6279	broad.mit.edu	37	chr1	153362985	153362985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tagacgtcgatgatagagttCaaggctttctccagctcggt	11	9	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:153362985C>G	uc001fbs.2	-	2	82	c.27G>C	c.(25-27)TTG>TTC	p.L9F		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	9					chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGATAGAGTTCAAGGCTTTCT	0.507													0	0	0	1	0	53	223										G	153362985	C	G	153362985	3	3	100	1	0	0	0	0	1	0	0	0	13786	825	29	1	262	1	S100A8	1	153362985	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1079589	153362985	95887636	59	30653										
ILF2	3608	broad.mit.edu	37	chr1	153638142	153638142	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagcaacaaatgcaaaccttCagaaggatcctgtgctctta	7	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:153638142C>T	uc001fcr.2	-	7	538	c.457G>A	c.(457-459)GAA>AAA	p.E153K	ILF2_uc010pdy.1_Missense_Mutation_p.E115K|ILF2_uc009wok.2_Intron|ILF2_uc009wol.1_Missense_Mutation_p.E115K	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	153	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCAAACCTTCAGAAGGATCC	0.388													0	0	0	1	0	8	145										T	153638142	C	T	153638142	3	4	100	1	0	0	0	0	1	0	0	0	7711	835	29	1	747	1	ILF2	1	153638142	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	275157	153638142	95612479	60	30654										
FDPS	2224	broad.mit.edu	37	chr1	155288696	155288696	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctttctactccttctaccttCctatagctgcagccatgtac	4	15	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:155288696C>G	uc001fkc.2	+	8	1042	c.823C>G	c.(823-825)CCT>GCT	p.P275A	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.P209A|FDPS_uc001fke.2_Missense_Mutation_p.P275A|FDPS_uc001fkf.2_Missense_Mutation_p.P209A|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank|RUSC1_uc009wqn.1_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	275					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	CTTCTACCTTCCTATAGCTGC	0.498													0	0	0	1	0	70	86										G	155288696	C	G	155288696	3	3	100	1	0	0	0	0	1	0	0	0	5803	855	30	1	849	1	FDPS	1	155288696	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1650554	155288696	93961925	61	30655										
ASH1L	55870	broad.mit.edu	37	chr1	155448304	155448304	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggagtcctgctggttgtaaGaaaggcctcctgtcgaagta	14	8	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:155448304G>C	uc009wqq.2	-	3	4837	c.4357C>G	c.(4357-4359)CTT>GTT	p.L1453V	ASH1L_uc001fkt.2_Missense_Mutation_p.L1453V|ASH1L_uc009wqr.1_Missense_Mutation_p.L1453V	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1453					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTGGTTGTAAGAAAGGCCTCC	0.493													0	0	0	1	0	26	112										C	155448304	G	C	155448304	3	2	100	1	0	0	0	0	1	0	0	0	1041	942	33	1	4641	1	ASH1L	1	155448304	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	159608	155448304	93802317	62	30656										
BCAN	63827	broad.mit.edu	37	chr1	156622477	156622477	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgagctatctggggtccctCgaggagagagcgaggagaca	16	9	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:156622477C>T	uc001fpp.2	+	8	2071	c.1735C>T	c.(1735-1737)CGA>TGA	p.R579*	BCAN_uc001fpo.2_Nonsense_Mutation_p.R579*	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	579					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGGGTCCCTCGAGGAGAGAG	0.642													0	0	0	1	0	24	32										T	156622477	C	T	156622477	4	4	100	1	0	0	0	0	0	1	0	0	1345	876	31	1	1761	1	BCAN	1	156622477	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1174173	156622477	92628144	63	30657										
SPTA1	6708	broad.mit.edu	37	chr1	158615287	158615287	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgacttttgtagttttacctGatgtctctccagcaagatct	7	9	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:158615287G>A	uc001fst.1	-	28	4193	c.3994C>T	c.(3994-3996)CAG>TAG	p.Q1332*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1332	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGTTTTACCTGATGTCTCTCC	0.448													0	0	0	1	0	43	74										A	158615287	G	A	158615287	4	1	100	1	0	0	0	0	0	1	0	0	15115	1299	45	1	3365	1	SPTA1	1	158615287	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1992810	158615287	90635334	64	30658										
OR6N1	128372	broad.mit.edu	37	chr1	158735776	158735776	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggagatggccttcctcttgcCggcagctgagggaattctga	14	10	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:158735776C>A	uc010piq.1	-	1	697	c.697G>T	c.(697-699)GGC>TGC	p.G233C		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TTCCTCTTGCCGGCAGCTGAG	0.498													1	0	3.62531e-18	1	4.02504e-18	32	104										A	158735776	C	A	158735776	3	1	100	1	0	0	0	0	1	0	0	0	11206	652	23	4	244	4	OR6N1	1	158735776	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	120489	158735776	90514845	65	30659										
OR10J1	26476	broad.mit.edu	37	chr1	159409997	159409997	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catggttattatgaacaagaGgctgcgtatccaacttgtcc	9	9	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:159409997G>C	uc010piv.1	+	1	449	c.449G>C	c.(448-450)AGG>ACG	p.R150T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	150	Cytoplasmic (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					ATGAACAAGAGGCTGCGTATC	0.488													0	0	0	1	0	11	155										C	159409997	G	C	159409997	3	2	100	1	0	0	0	0	1	0	0	0	10910	1000	35	4	451	4	OR10J1	1	159409997	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	674221	159409997	89840624	66	30660										
CCDC19	25790	broad.mit.edu	37	chr1	159857685	159857685	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atccgcagcttgttggctctCtgcaggaggttctgggcccg	14	12	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:159857685C>G	uc001fui.2	-	5	552	c.534G>C	c.(532-534)CAG>CAC	p.Q178H	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.Q93H|CCDC19_uc001ful.2_Missense_Mutation_p.Q93H|CCDC19_uc009wtc.1_Missense_Mutation_p.Q178H	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	178	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TGTTGGCTCTCTGCAGGAGGT	0.552													0	0	0	1	0	94	101										G	159857685	C	G	159857685	3	3	100	1	0	0	0	0	1	0	0	0	2795	912	32	1	1153	1	CCDC19	1	159857685	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	447688	159857685	89392936	67	30661										
PIGM	93183	broad.mit.edu	37	chr1	160000857	160000857	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tacaaacagcagcacagcccGattacacagccttttcagga	7	13	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160000857G>C	uc001fuv.1	-	1	927	c.673C>G	c.(673-675)CGG>GGG	p.R225G		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	225	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCACAGCCCGATTACACAGC	0.488													0	0	0	1	0	35	127										C	160000857	G	C	160000857	3	2	100	1	0	0	0	0	1	0	0	0	11892	1057	37	1	602	1	PIGM	1	160000857	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	143172	160000857	89249764	68	30662										
ATP1A2	477	broad.mit.edu	37	chr1	160098576	160098576	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accctcacccagaaccgcatGaccgtcgcccacatgtggtt	8	17	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160098576G>A	uc001fvc.2	+	9	1284	c.1152G>A	c.(1150-1152)ATG>ATA	p.M384I	ATP1A2_uc001fvb.2_Missense_Mutation_p.M384I|ATP1A2_uc010piz.1_Missense_Mutation_p.M229I|ATP1A2_uc001fvd.2_Missense_Mutation_p.M120I|ATP1A2_uc009wtg.1_Missense_Mutation_p.M72I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	384	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AGAACCGCATGACCGTCGCCC	0.592													0	0	0	1	0	28	73										A	160098576	G	A	160098576	3	1	100	1	0	0	0	0	1	0	0	0	1129	1290	45	1	1186	1	ATP1A2	1	160098576	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	97719	160098576	89152045	69	30663										
LY9	4063	broad.mit.edu	37	chr1	160766040	160766040	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctttctccagtaagccacaGaggagtcagctgcaaatatt	8	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160766040G>A	uc001fwu.2	+	1	113	c.63G>A	c.(61-63)CAG>CAA	p.Q21Q	LY9_uc001fwt.2_Silent_p.Q21Q|LY9_uc010pjs.1_Silent_p.Q21Q|LY9_uc001fwv.2_Silent_p.Q21Q|LY9_uc001fww.2_Silent_p.Q21Q|LY9_uc001fwx.2_Silent_p.Q21Q	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	21					cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GTAAGCCACAGAGGAGTCAGC	0.498													0	0	0	1	0	29	112										A	160766040	G	A	160766040	2	1	100	1	0	0	0	0	0	0	0	1	9101	933	33	1		1	LY9	1	160766040	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	667464	160766040	88484581	70	30664										
LY9	4063	broad.mit.edu	37	chr1	160794037	160794037	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actgctccatacggaaacctCaggtggtgagaactacattc	9	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160794037C>G	uc001fwu.2	+	9	1947	c.1897C>G	c.(1897-1899)CAG>GAG	p.Q633E	LY9_uc001fwv.2_Missense_Mutation_p.Q619E|LY9_uc001fww.2_Missense_Mutation_p.Q543E|LY9_uc001fwx.2_Intron|LY9_uc001fwz.2_Intron	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	633	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACGGAAACCTCAGGTGGTGAG	0.488													0	0	0	1	0	22	101										G	160794037	C	G	160794037	3	3	100	1	0	0	0	0	1	0	0	0	9101	827	29	1	2063	1	LY9	1	160794037	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	27997	160794037	88456584	71	30665										
HSD17B7	51478	broad.mit.edu	37	chr1	162767598	162767598	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttctgctgtttcagaaaagtGattcatatgttctccacagc	7	9	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:162767598G>A	uc001gci.2	+	4	434	c.339G>A	c.(337-339)GTG>GTA	p.V113V	HSD17B7_uc009wuv.2_RNA	NM_016371	NP_057455	P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	113	Extracellular (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			ovary(1)	1	all_hematologic(112;0.115)				NADH(DB00157)	TCAGAAAAGTGATTCATATGT	0.433													0	0	0	1	0	5	35										A	162767598	G	A	162767598	2	1	100	1	0	0	0	0	0	0	0	1	7388	1277	45	1		1	HSD17B7	1	162767598	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1973561	162767598	86483023	72	30666										
GPA33	10223	broad.mit.edu	37	chr1	167024974	167024974	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggctgctcttacgagatctGacggccaccgtgatgttgca	12	11	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:167024974G>C	uc001gea.1	-	5	1028	c.684C>G	c.(682-684)GTC>GTG	p.V228V		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	228	Extracellular (Potential).					integral to plasma membrane	receptor activity				0						TACGAGATCTGACGGCCACCG	0.557													0	0	0	1	0	19	78										C	167024974	G	C	167024974	2	2	100	1	0	0	0	0	0	0	0	1	6586	1277	45	1		1	GPA33	1	167024974	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4257376	167024974	82225647	73	30667										
DCAF6	55827	broad.mit.edu	37	chr1	168035698	168035698	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttttaaccgaaaacttgctGatgaagtaagatttttattg	7	4	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:168035698G>C	uc001gew.2	+	17	2649	c.2407G>C	c.(2407-2409)GAT>CAT	p.D803H	DCAF6_uc001gev.2_Missense_Mutation_p.D823H|DCAF6_uc001gex.2_Missense_Mutation_p.D894H|DCAF6_uc010plk.1_Missense_Mutation_p.D863H|DCAF6_uc001gey.2_Missense_Mutation_p.D676H|DCAF6_uc001gez.2_Missense_Mutation_p.D106H	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	803					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAAACTTGCTGATGAAGTAAG	0.289													0	0	0	1	0	4	55										C	168035698	G	C	168035698	3	2	100	1	0	0	0	0	1	0	0	0	4274	1290	45	1	2537	1	DCAF6	1	168035698	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1010724	168035698	81214923	74	30668										
C1orf156	92342	broad.mit.edu	37	chr1	169762167	169762167	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attaggtaaggttacttcatCaatcaccatactgttataat	5	7	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:169762167C>G	uc001ggn.2	-	2	948	c.670G>C	c.(670-672)GAT>CAT	p.D224H	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank|C1orf112_uc009wvt.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	224						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTTACTTCATCAATCACCATA	0.373													0	0	0	1	0	35	173										G	169762167	C	G	169762167	3	3	100	1	0	0	0	0	1	0	0	0	2006	826	29	1	452	1	C1orf156	1	169762167	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1726469	169762167	79488454	75	30669										
BAT2L2	23215	broad.mit.edu	37	chr1	171482304	171482304	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caaaacaagagcaacatgaaGaagaaaagtgagtcaaagtc	9	6	1	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:171482304G>C	uc010pmg.1	+	3	543	c.277G>C	c.(277-279)GAA>CAA	p.E93Q	BAT2L2_uc001ghq.1_Missense_Mutation_p.E95Q|BAT2L2_uc001ghr.1_Missense_Mutation_p.E95Q	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	93							protein C-terminus binding				0						GCAACATGAAGAAGAAAAGTG	0.398													0	0	0	1	0	7	26										C	171482304	G	C	171482304	3	2	100	1	0	0	0	0	1	0	0	0	1321	943	33	1	283	1	BAT2L2	1	171482304	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1720137	171482304	77768317	76	30670										
BAT2L2	23215	broad.mit.edu	37	chr1	171501557	171501557	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcagcaagtagctgatgaaGatgaaatatggaagcaaaga	12	4	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:171501557G>C	uc010pmg.1	+	12	1590	c.1324G>C	c.(1324-1326)GAT>CAT	p.D442H	BAT2L2_uc001ghr.1_Missense_Mutation_p.D444H	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	442							protein C-terminus binding				0						AGCTGATGAAGATGAAATATG	0.473													0	0	0	1	0	10	29										C	171501557	G	C	171501557	3	2	100	1	0	0	0	0	1	0	0	0	1321	942	33	1	1366	1	BAT2L2	1	171501557	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	19253	171501557	77749064	77	30671										
MYOC	4653	broad.mit.edu	37	chr1	171621212	171621212	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggggacactggccccttctCagccttgctacctcctggct	10	16	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:171621212C>T	uc001ghu.2	-	1	562	c.540G>A	c.(538-540)CTG>CTA	p.L180L	MYOC_uc010pmk.1_Silent_p.L122L	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	180	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GGCCCCTTCTCAGCCTTGCTA	0.562													0	0	0	1	0	82	275										T	171621212	C	T	171621212	2	4	100	1	0	0	0	0	0	0	0	1	10086	813	29	1		1	MYOC	1	171621212	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	119655	171621212	77629409	78	30672										
SLC9A11	284525	broad.mit.edu	37	chr1	173523900	173523900	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctggctgactgagtcatcacGtatgaatttattcccattgt	8	9	2	3	rs138213092		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:173523900G>C	uc001giz.2	-	11	1692	c.1269C>G	c.(1267-1269)TAC>TAG	p.Y423*	SLC9A11_uc009wwe.2_Intron|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	423	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GAGTCATCACGTATGAATTTA	0.328													0	0	0	1	0	27	135										C	173523900	G	C	173523900	4	2	100	1	0	0	0	0	0	1	0	0	14711	1140	40	4	2177	4	SLC9A11	1	173523900	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1902688	173523900	75726721	79	30673										
TNR	7143	broad.mit.edu	37	chr1	175375427	175375427	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacctccctctccagcatctCgatccggctcagcagctcct	6	20	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:175375427C>G	uc001gkp.1	-	1	505	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	TNR_uc009wwu.1_Missense_Mutation_p.E142Q|TNR_uc010pmz.1_Missense_Mutation_p.E142Q	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	142	Potential.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCAGCATCTCGATCCGGCTC	0.602													0	0	0	1	0	20	76										G	175375427	C	G	175375427	3	3	100	1	0	0	0	0	1	0	0	0	16335	893	31	1	3736	1	TNR	1	175375427	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1851527	175375427	73875194	80	30674										
RALGPS2	55103	broad.mit.edu	37	chr1	178848093	178848093	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actctgttcagtatatagaaGaactacaaaaatttgtggaa	7	5	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:178848093G>C	uc001glz.2	+	10	1140	c.802G>C	c.(802-804)GAA>CAA	p.E268Q	RALGPS2_uc001gly.1_Missense_Mutation_p.E268Q|RALGPS2_uc010pnb.1_Missense_Mutation_p.E268Q	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	268	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						GTATATAGAAGAACTACAAAA	0.338													0	0	0	1	0	10	32										C	178848093	G	C	178848093	3	2	100	1	0	0	0	0	1	0	0	0	13018	943	33	1	836	1	RALGPS2	1	178848093	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3472666	178848093	70402528	81	30675										
SMG7	9887	broad.mit.edu	37	chr1	183515224	183515224	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagaccccataaaactgtttGagccgtcattgcaacctcct	6	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:183515224G>C	uc001gqg.2	+	17	2616	c.2494G>C	c.(2494-2496)GAG>CAG	p.E832Q	SMG7_uc010pob.1_Missense_Mutation_p.E815Q|SMG7_uc001gqf.2_Missense_Mutation_p.E786Q|SMG7_uc001gqh.2_Missense_Mutation_p.E786Q|SMG7_uc001gqi.2_Missense_Mutation_p.E744Q|SMG7_uc010poc.1_Missense_Mutation_p.E790Q	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	832	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AAAACTGTTTGAGCCGTCATT	0.463													0	0	0	1	0	16	55										C	183515224	G	C	183515224	3	2	100	1	0	0	0	0	1	0	0	0	14798	1291	45	1	2560	1	SMG7	1	183515224	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4667131	183515224	65735397	82	30676										
EDEM3	80267	broad.mit.edu	37	chr1	184686740	184686740	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgttgagcccagtgtactctGaaatctgtggtaaatgcctg	11	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:184686740G>C	uc010pok.1	-	12	1440	c.1179C>G	c.(1177-1179)TTC>TTG	p.F393L	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.F393L	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	393					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						AGTGTACTCTGAAATCTGTGG	0.294													0	0	0	1	0	7	18										C	184686740	G	C	184686740	3	2	100	1	0	0	0	0	1	0	0	0	4913	1281	45	1	1655	1	EDEM3	1	184686740	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1171516	184686740	64563881	83	30677										
HMCN1	83872	broad.mit.edu	37	chr1	186083224	186083224	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caaggataacatggagaaagGatggagctgttctagctggg	15	5	1	1	rs138705216	by1000genomes	TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:186083224G>T	uc001grq.1	+	73	11474	c.11245G>T	c.(11245-11247)GAT>TAT	p.D3749Y		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3749	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATGGAGAAAGGATGGAGCTGT	0.388													1	0	9.8876e-21	1	1.10381e-20	38	35										T	186083224	G	T	186083224	3	4	100	1	0	0	0	0	1	0	0	0	7220	1174	41	3	11535	3	HMCN1	1	186083224	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1396484	186083224	63167397	84	30678										
F13B	2165	broad.mit.edu	37	chr1	197019986	197019986	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccatgtttaataagaggagGagatgtgcacattcctttag	10	6	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:197019986G>A	uc001gtt.1	-	10	1623	c.1579C>T	c.(1579-1581)CCT>TCT	p.P527S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	527	Sushi 9.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATAAGAGGAGGAGATGTGCAC	0.313													0	0	0	1	0	16	21										A	197019986	G	A	197019986	3	1	100	1	0	0	0	0	1	0	0	0	5341	1174	41	1	418	1	F13B	1	197019986	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	10936762	197019986	52230635	85	30679										
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200708985	200708985	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctgcagaccccagggagatGagaaagacgttcattgttcc	12	10	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:200708985G>C	uc001gvl.2	+	1	300	c.30G>C	c.(28-30)ATG>ATC	p.M10I	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.M10I|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.M10I	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	10						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCAGGGAGATGAGAAAGACGT	0.592													0	0	0	1	0	7	14										C	200708985	G	C	200708985	3	2	100	1	0	0	0	0	1	0	0	0	2612	1290	45	1	32	1	CAMSAP1L1	1	200708985	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3688999	200708985	48541636	86	30680										
BTG2	7832	broad.mit.edu	37	chr1	203276294	203276294	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctccggctaccgctgcattCgcatcaaccacaagatggac	9	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:203276294C>G	uc001gzq.2	+	2	276	c.205C>G	c.(205-207)CGC>GGC	p.R69G	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	69					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			CCGCTGCATTCGCATCAACCA	0.612													0	0	0	1	0	15	19										G	203276294	C	G	203276294	3	3	100	1	0	0	0	0	1	0	0	0	1554	884	31	1	211	1	BTG2	1	203276294	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2567309	203276294	45974327	87	30681										
PIK3C2B	5287	broad.mit.edu	37	chr1	204400860	204400860	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtaattcctggaactcctcaAaggtccgctggatgtaggtg	12	9	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:204400860A>G	uc001haw.2	-	29	4696	c.4217T>C	c.(4216-4218)TTT>TCT	p.F1406S	PIK3C2B_uc010pqv.1_Missense_Mutation_p.F1378S	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1406	PX.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAACTCCTCAAAGGTCCGCTG	0.527											OREG0014134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	7	134										G	204400860	A	G	204400860	3	3	100	1	0	0	0	0	1	0	0	0	11910	14	1	5	711	5	PIK3C2B	1	204400860	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1124566	204400860	44849761	88	30682										
PIK3C2B	5287	broad.mit.edu	37	chr1	204438084	204438084	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ataggtgcgggggggcacctGagggggcatagtcttgctcc	18	9	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:204438084G>A	uc001haw.2	-	3	1326	c.847C>T	c.(847-849)CAG>TAG	p.Q283*	PIK3C2B_uc010pqv.1_Nonsense_Mutation_p.Q283*|PIK3C2B_uc001hax.1_Nonsense_Mutation_p.Q283*|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	283	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGGGGCACCTGAGGGGGCATA	0.642													0	0	0	1	0	23	79										A	204438084	G	A	204438084	4	1	100	1	0	0	0	0	0	1	0	0	11910	1299	45	1	4185	1	PIK3C2B	1	204438084	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	37224	204438084	44812537	89	30683										
INTS7	25896	broad.mit.edu	37	chr1	212120009	212120009	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggaaagaaaggggaactttCagcaaagcaatgatggcatt	12	5	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:212120009C>T	uc001hiw.1	-	18	2460	c.2355G>A	c.(2353-2355)CTG>CTA	p.L785L	INTS7_uc009xdb.1_Intron|INTS7_uc001hix.1_Silent_p.L661L|INTS7_uc001hiy.1_Silent_p.L771L|INTS7_uc010pta.1_Silent_p.L736L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	785					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GGGGAACTTTCAGCAAAGCAA	0.343													0	0	0	1	0	41	25										T	212120009	C	T	212120009	2	4	100	1	0	0	0	0	0	0	0	1	7783	813	29	1		1	INTS7	1	212120009	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	7681925	212120009	37130612	90	30684										
PTPN14	5784	broad.mit.edu	37	chr1	214542945	214542945	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagaatccgttcgaaacttCgtggtgaccttgaacttgcc	9	11	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:214542945C>T	uc001hkk.1	-	17	3397	c.3126G>A	c.(3124-3126)ACG>ACA	p.T1042T		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1042	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TTCGAAACTTCGTGGTGACCT	0.488													0	0	0	1	0	67	153										T	214542945	C	T	214542945	2	4	100	1	0	0	0	0	0	0	0	1	12783	871	31	1		1	PTPN14	1	214542945	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2422936	214542945	34707676	91	30685										
IARS2	55699	broad.mit.edu	37	chr1	220273958	220273958	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagaacttggtagagaagctCagaatctttcagctatggaa	10	7	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:220273958C>G	uc001hmc.2	+	3	621	c.517C>G	c.(517-519)CAG>GAG	p.Q173E		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	173					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TAGAGAAGCTCAGAATCTTTC	0.348													0	0	0	1	0	10	37										G	220273958	C	G	220273958	3	3	100	1	0	0	0	0	1	0	0	0	7474	827	29	1	527	1	IARS2	1	220273958	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5731013	220273958	28976663	92	30686										
FAM177B	400823	broad.mit.edu	37	chr1	222923383	222923383	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccatacaacaggatgtgacaGaggccattcctcagtgaagc	10	11	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:222923383G>A	uc001hnt.2	+	6	726	c.460G>A	c.(460-462)GAG>AAG	p.E154K	uc001hnr.1_Intron|FAM177B_uc009xeb.2_RNA	NM_207468	NP_997351	A6PVY3	F177B_HUMAN	hypothetical protein LOC400823	154										ovary(1)	1						GGATGTGACAGAGGCCATTCC	0.522													0	0	0	1	0	14	53										A	222923383	G	A	222923383	3	1	100	1	0	0	0	0	1	0	0	0	5502	943	33	1	474	1	FAM177B	1	222923383	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2649425	222923383	26327238	93	30687										
CNIH3	149111	broad.mit.edu	37	chr1	224804936	224804936	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctggtgctgtgcgctgcgctCatcttcttcgccatctggca	11	14	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:224804936C>T	uc001hos.1	+	1	758	c.60C>T	c.(58-60)CTC>CTT	p.L20L		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	20	Helical; (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		GCGCTGCGCTCATCTTCTTCG	0.557													0	0	0	1	0	37	178										T	224804936	C	T	224804936	2	4	100	1	0	0	0	0	0	0	0	1	3604	813	29	1		1	CNIH3	1	224804936	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1881553	224804936	24445685	94	30688										
WNT3A	89780	broad.mit.edu	37	chr1	228210569	228210569	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggtggaactgcaccaccgtCcacgacagcctggccatctt	10	16	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:228210569C>T	uc001hrq.1	+	2	351	c.273C>T	c.(271-273)GTC>GTT	p.V91V	WNT3A_uc001hrp.1_Silent_p.V91V	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	91					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				GCACCACCGTCCACGACAGCC	0.642													0	0	0	1	0	21	27										T	228210569	C	T	228210569	2	4	100	1	0	0	0	0	0	0	0	1	17386	842	30	1		1	WNT3A	1	228210569	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3405633	228210569	21040052	95	30689										
OBSCN	84033	broad.mit.edu	37	chr1	228558384	228558384	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacctcggtctcccagaaatCcatgcctgcggaggaggccc	11	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:228558384C>G	uc009xez.1	+	93	20215	c.20171C>G	c.(20170-20172)TCC>TGC	p.S6724C	OBSCN_uc001hsr.1_Missense_Mutation_p.S1353C	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6724					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCCCAGAAATCCATGCCTGCG	0.632													0	0	0	1	0	18	26										G	228558384	C	G	228558384	3	3	100	1	0	0	0	0	1	0	0	0	10812	855	30	1	21747	1	OBSCN	1	228558384	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	347815	228558384	20692237	96	30690										
CAPN9	10753	broad.mit.edu	37	chr1	230937333	230937333	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagttcatccatttgacaatGaacatctgaggctgccttgt	8	10	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:230937333G>T	uc001htz.1	+	20	2177	c.2064G>T	c.(2062-2064)ATG>ATT	p.M688I	CAPN9_uc009xfg.1_Missense_Mutation_p.M625I|CAPN9_uc001hua.1_Missense_Mutation_p.M662I	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	688	Domain IV.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				ATTTGACAATGAACATCTGAG	0.532													1	0	1.22574e-08	1	1.29716e-08	22	63										T	230937333	G	T	230937333	3	4	100	1	0	0	0	0	1	0	0	0	2632	1290	45	3	2142	3	CAPN9	1	230937333	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2378949	230937333	18313288	97	30691										
SIPA1L2	57568	broad.mit.edu	37	chr1	232564265	232564265	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagcatctcccaccactgtCtgatgctgagttgctgtgga	10	12	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:232564265C>G	uc001hvg.2	-	15	4460	c.4302G>C	c.(4300-4302)CAG>CAC	p.Q1434H	SIPA1L2_uc001hvf.2_Missense_Mutation_p.Q508H	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1434					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCACCACTGTCTGATGCTGAG	0.443													0	0	0	1	0	27	46										G	232564265	C	G	232564265	3	3	100	1	0	0	0	0	1	0	0	0	14330	912	32	1	894	1	SIPA1L2	1	232564265	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1626932	232564265	16686356	98	30692										
SIPA1L2	57568	broad.mit.edu	37	chr1	232650028	232650028	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagtggttatgtttttccttTtccccacattagccctcgta	6	12	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:232650028T>C	uc001hvg.2	-	1	1216	c.1058A>G	c.(1057-1059)AAA>AGA	p.K353R		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	353					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GTTTTTCCTTTTCCCCACATT	0.493													0	0	0	1	0	20	87										C	232650028	T	C	232650028	3	2	100	1	0	0	0	0	1	0	0	0	14330	1841	64	5	4194	5	SIPA1L2	1	232650028	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	85763	232650028	16600593	99	30693										
LYST	1130	broad.mit.edu	37	chr1	235887452	235887453	+	Missense_Mutation	DNP	GA	GA	TT													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcatatgtccaggaaaatGatgctggttccaactctccc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:235887452_235887453GA>TT	uc001hxj.2	-	39	9365_9366	c.9190_9191TC>AA	c.(9190-9192)TCA>AAA	p.S3064K	LYST_uc001hxi.2_Missense_Mutation_p.S288K	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3064					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CCAGGAAAATGATGCTGGTTCC	0.317									Chediak-Higashi_syndrome				0	0	0	1	0	14	161										TT	235887453	GA	TT	235887452	3	4	100	1	0	0	0	0	1	0	0	0	9128	1294	45	3	2274	3	LYST	1	235887452	Missense_Mutation	DNP	GA	TCGA-G2-A3VY-01A-11D-A22Z-08	3237424	235887452	13363169	100	30694										
ACTN2	88	broad.mit.edu	37	chr1	236899015	236899015	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accacgcttttgcgggcgcgGagcaggtactcaacacttgt	12	12	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:236899015G>A	uc001hyf.2	+	8	982	c.778G>A	c.(778-780)GAG>AAG	p.E260K	ACTN2_uc001hyg.2_Missense_Mutation_p.E15K|ACTN2_uc009xgi.1_Intron|ACTN2_uc010pxu.1_Intron	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	260					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGCGGGCGCGGAGCAGGTACT	0.498													0	0	0	1	0	26	15										A	236899015	G	A	236899015	3	1	100	1	0	0	0	0	1	0	0	0	205	1175	41	1	808	1	ACTN2	1	236899015	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1011563	236899015	12351606	101	30695										
FH	2271	broad.mit.edu	37	chr1	241663871	241663871	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catcccccagcagcctggctGagtgtaacacatttttaatc	7	13	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:241663871G>A	uc001hyx.2	-	9	1288	c.1256C>T	c.(1255-1257)TCA>TTA	p.S419L		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	419					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		CAGCCTGGCTGAGTGTAACAC	0.323			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				0	0	0	1	0	51	24										A	241663871	G	A	241663871	3	1	100	1	0	0	0	0	1	0	0	0	5875	1294	45	1	284	1	FH	1	241663871	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4764856	241663871	7586750	102	30696										
KMO	8564	broad.mit.edu	37	chr1	241714300	241714300	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagcaagaatgatccactctCtttcaggaaaaaagtctgca	8	9	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:241714300C>G	uc009xgp.2	+	4	333	c.268C>G	c.(268-270)CTT>GTT	p.L90V	KMO_uc001hyy.2_Missense_Mutation_p.L90V|KMO_uc009xgo.1_Missense_Mutation_p.L90V	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	90					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GATCCACTCTCTTTCAGGAAA	0.398													0	0	0	1	0	51	101										G	241714300	C	G	241714300	3	3	100	1	0	0	0	0	1	0	0	0	8424	913	32	1	282	1	KMO	1	241714300	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	50429	241714300	7536321	103	30697										
KIDINS220	57498	broad.mit.edu	37	chr2	8933973	8933973	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgagttaaaatactcttctGatggctacagtcaatattat	6	6	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:8933973G>A	uc002qzc.2	-	12	1425	c.1243C>T	c.(1243-1245)CAG>TAG	p.Q415*	KIDINS220_uc010yiv.1_Nonsense_Mutation_p.Q181*|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.Q373*|KIDINS220_uc010yiw.1_Nonsense_Mutation_p.Q416*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	415	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATACTCTTCTGATGGCTACAG	0.358													0	0	0	1	0	7	70										A	8933973	G	A	8933973	4	1	100	1	0	0	0	0	0	1	0	0	8271	1299	45	1	4148	1	KIDINS220	2	8933973	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		8933973	234265400	104	30698										
NCOA1	8648	broad.mit.edu	37	chr2	24952432	24952432	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caagcaacgccacctttgatCatggaagaaagacccaacct	7	13	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:24952432C>G	uc002rfk.2	+	15	3207	c.2949C>G	c.(2947-2949)ATC>ATG	p.I983M	NCOA1_uc010eye.2_Missense_Mutation_p.I983M|NCOA1_uc002rfi.2_Missense_Mutation_p.I832M|NCOA1_uc002rfj.2_Missense_Mutation_p.I983M|NCOA1_uc002rfl.2_Missense_Mutation_p.I983M	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	983	Interaction with CREBBP.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTTTGATCATGGAAGAAA	0.428			T	PAX3	alveolar rhadomyosarcoma								0	0	0	1	0	29	154										G	24952432	C	G	24952432	3	3	100	1	0	0	0	0	1	0	0	0	10228	816	29	1	2999	1	NCOA1	2	24952432	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	16018459	24952432	218246941	105	30699										
NCOA1	8648	broad.mit.edu	37	chr2	24985619	24985619	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agctctcatccactgaccttCtcaaaacagaagcagatgga	7	12	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:24985619C>G	uc002rfk.2	+	20	4387	c.4129C>G	c.(4129-4131)CTC>GTC	p.L1377V	NCOA1_uc010eye.2_Missense_Mutation_p.L1377V|NCOA1_uc002rfi.2_Missense_Mutation_p.L1226V|NCOA1_uc002rfj.2_Missense_Mutation_p.L1377V|NCOA1_uc002rfl.2_Missense_Mutation_p.L1377V|NCOA1_uc010eyf.2_Intron	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1377									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTGACCTTCTCAAAACAGA	0.373			T	PAX3	alveolar rhadomyosarcoma								0	0	0	1	0	51	261										G	24985619	C	G	24985619	3	3	100	1	0	0	0	0	1	0	0	0	10228	913	32	1	4199	1	NCOA1	2	24985619	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	33187	24985619	218213754	106	30700										
GPR113	165082	broad.mit.edu	37	chr2	26532908	26532908	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggatctgaaggcagcaactCaccagggagatggtggagct	15	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:26532908C>G	uc002rhe.3	-	13	3144	c.3144G>C	c.(3142-3144)GTG>GTC	p.V1048V	GPR113_uc010yky.1_Intron|GPR113_uc002rhb.1_Intron|GPR113_uc010eyk.1_Intron|GPR113_uc002rhc.1_Intron|GPR113_uc002rhd.1_Intron	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	1048	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAGCAACTCACCAGGGAGA	0.572													0	0	0	1	0	14	76										G	26532908	C	G	26532908	2	3	100	1	0	0	0	0	0	0	0	1	6630	813	29	1		1	GPR113	2	26532908	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1547289	26532908	216666465	107	30701										
C2orf53	339779	broad.mit.edu	37	chr2	27360495	27360495	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggttctgcctagccacaggtGctgcaaaagcagtagccgca	12	12	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27360495G>T	uc002rjb.2	-	3	1283	c.703C>A	c.(703-705)CAC>AAC	p.H235N	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	235											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCCACAGGTGCTGCAAAAGC	0.687													1	0	1.61879e-10	1	1.73479e-10	12	48										T	27360495	G	T	27360495	3	4	100	1	0	0	0	0	1	0	0	0	2174	1319	46	4	539	4	C2orf53	2	27360495	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	827587	27360495	215838878	108	30702										
GTF3C2	2976	broad.mit.edu	37	chr2	27559164	27559164	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctcattcatgtcagggctgGagaaaagagccacatattgc	10	9	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27559164G>C	uc002rjv.1	-	9	1619	c.1256C>G	c.(1255-1257)TCC>TGC	p.S419C	GTF3C2_uc010eyy.1_5'Flank|GTF3C2_uc002rju.1_Missense_Mutation_p.S430C|GTF3C2_uc002rjw.1_Missense_Mutation_p.S419C|GTF3C2_uc010eyz.1_Missense_Mutation_p.S419C|uc002rjy.1_RNA	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	419						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCAGGGCTGGAGAAAAGAGC	0.617													0	0	0	1	0	33	133										C	27559164	G	C	27559164	3	2	100	1	0	0	0	0	1	0	0	0	6873	1174	41	1	1527	1	GTF3C2	2	27559164	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	198669	27559164	215640209	109	30703										
ZNF513	130557	broad.mit.edu	37	chr2	27603017	27603017	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gttgccgtcgccttcctcctCttcctcttcctcctcaaact	4	19	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27603017C>G	uc002rkk.2	-	2	354	c.154G>C	c.(154-156)GAG>CAG	p.E52Q	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	52	Poly-Glu.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCCTCCTCTTCCTCTTCC	0.562													0	0	0	1	0	17	263										G	27603017	C	G	27603017	3	3	100	1	0	0	0	0	1	0	0	0	17955	922	32	1	1483	1	ZNF513	2	27603017	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	43853	27603017	215596356	110	30704										
C2orf16	84226	broad.mit.edu	37	chr2	27804354	27804354	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtccctctcagaggagccatCgcggtccctctcagagaaga	11	14	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27804354C>T	uc002rkz.3	+	1	4966	c.4915C>T	c.(4915-4917)CGC>TGC	p.R1639C	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1639	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GAGGAGCCATCGCGGTCCCTC	0.577													0	0	0	1	0	50	297										T	27804354	C	T	27804354	3	4	100	1	0	0	0	0	1	0	0	0	2157	884	31	1	4917	1	C2orf16	2	27804354	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	201337	27804354	215395019	111	30705										
SLC4A1AP	22950	broad.mit.edu	37	chr2	27886635	27886635	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttctcatgttagcaccacttCgcaacgctccaggtcgtgaa	8	13	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27886635C>A	uc002rlk.3	+	1	298	c.16C>A	c.(16-18)CGC>AGC	p.R6S	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	6						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					AGCACCACTTCGCAACGCTCC	0.517													1	0	2.2871e-25	1	2.57583e-25	37	164										A	27886635	C	A	27886635	3	1	100	1	0	0	0	0	1	0	0	0	14653	884	31	3	18	3	SLC4A1AP	2	27886635	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	82281	27886635	215312738	112	30706										
BRE	9577	broad.mit.edu	37	chr2	28248194	28248194	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caatgtagccgcctccgggaGagctcccgcctcatgtttga	11	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:28248194G>A	uc002rlr.2	+	6	720	c.402G>A	c.(400-402)GAG>GAA	p.E134E	BRE_uc002rlp.1_Silent_p.E134E|BRE_uc002rlq.2_Silent_p.E134E|BRE_uc002rls.2_Silent_p.E134E|BRE_uc002rlt.2_Silent_p.E134E|BRE_uc002rlu.2_Silent_p.E134E|BRE_uc002rlv.2_5'UTR	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	134	UEV-like 1.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCCTCCGGGAGAGCTCCCGCC	0.453													0	0	0	1	0	90	42										A	28248194	G	A	28248194	2	1	100	1	0	0	0	0	0	0	0	1	1509	933	33	1		1	BRE	2	28248194	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	361559	28248194	214951179	113	30707										
PLB1	151056	broad.mit.edu	37	chr2	28761192	28761192	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttctcctctcacagaatgggCttgcggcgggcggcgtggat	15	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:28761192C>G	uc002rmb.1	+	10	562	c.562C>G	c.(562-564)CTT>GTT	p.L188V	PLB1_uc010ezj.1_Missense_Mutation_p.L199V	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	188	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					ACAGAATGGGCTTGCGGCGGG	0.662													0	0	0	1	0	5	35										G	28761192	C	G	28761192	3	3	100	1	0	0	0	0	1	0	0	0	12024	797	28	4	633	4	PLB1	2	28761192	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	512998	28761192	214438181	114	30708										
RASGRP3	25780	broad.mit.edu	37	chr2	33768679	33768679	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcttggattccttctgtgTtctggacaaagatcagtaag	9	8	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:33768679T>A	uc002rox.2	+	14	2006	c.1379T>A	c.(1378-1380)GTT>GAT	p.V460D	RASGRP3_uc010ync.1_Missense_Mutation_p.V460D|RASGRP3_uc002roy.2_Missense_Mutation_p.V459D	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	460	EF-hand 2.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					TCCTTCTGTGTTCTGGACAAA	0.338													0	0	0	1	0	5	19										A	33768679	T	A	33768679	3	1	100	1	0	0	0	0	1	0	0	0	13076	1725	60	5	1421	5	RASGRP3	2	33768679	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	5007487	33768679	209430694	115	30709										
CRIM1	51232	broad.mit.edu	37	chr2	36583615	36583615	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcatcgtgcagggcgtctgCggctgctgctacacgtgcgc	15	13	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:36583615C>T	uc002rpd.2	+	1	219	c.180C>T	c.(178-180)TGC>TGT	p.C60C		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	60	IGFBP N-terminal.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				AGGGCGTCTGCGGCTGCTGCT	0.697													0	0	0	1	0	5	44										T	36583615	C	T	36583615	2	4	100	1	0	0	0	0	0	0	0	1	3873	776	27	2		2	CRIM1	2	36583615	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2814936	36583615	206615758	116	30710										
C2orf56	55471	broad.mit.edu	37	chr2	37473327	37473327	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtcatgatggaacaaagacaGataccttcagagtatgtata	9	6	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:37473327G>C	uc002rqa.3	+	8	1000	c.925G>C	c.(925-927)GAT>CAT	p.D309H	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.D211H|C2orf56_uc010ynk.1_Missense_Mutation_p.D238H|C2orf56_uc010ynl.1_Missense_Mutation_p.D282H|C2orf56_uc010fah.2_RNA	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	309					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				AACAAAGACAGATACCTTCAG	0.403													0	0	0	1	0	15	92										C	37473327	G	C	37473327	3	2	100	1	0	0	0	0	1	0	0	0	2177	942	33	1	955	1	C2orf56	2	37473327	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	889712	37473327	205726046	117	30711										
C2orf56	55471	broad.mit.edu	37	chr2	37474653	37474653	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgccccaggaacagcagatCtaacagctgatgtggacttc	10	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:37474653C>G	uc002rqa.3	+	9	1066	c.991C>G	c.(991-993)CTA>GTA	p.L331V	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.L233V|C2orf56_uc010ynk.1_Missense_Mutation_p.L260V|C2orf56_uc010ynl.1_Missense_Mutation_p.L304V|C2orf56_uc010fah.2_RNA	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	331					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				AACAGCAGATCTAACAGCTGA	0.398													0	0	0	1	0	11	175										G	37474653	C	G	37474653	3	3	100	1	0	0	0	0	1	0	0	0	2177	912	32	1	1025	1	C2orf56	2	37474653	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1326	37474653	205724720	118	30712										
LRPPRC	10128	broad.mit.edu	37	chr2	44161983	44161983	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttatacttttcatagcagtCaatggcgacctcaagagcag	8	9	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:44161983C>T	uc002rtr.2	-	24	2597	c.2539G>A	c.(2539-2541)GAC>AAC	p.D847N	LRPPRC_uc010yob.1_Missense_Mutation_p.D747N	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	847	PPR 13.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCATAGCAGTCAATGGCGACC	0.363													0	0	0	1	0	10	77										T	44161983	C	T	44161983	3	4	100	1	0	0	0	0	1	0	0	0	8965	826	29	1	1705	1	LRPPRC	2	44161983	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6687330	44161983	199037390	119	30713										
EPAS1	2034	broad.mit.edu	37	chr2	46583940	46583940	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attcgtgagaacctgagtctCaaaaatggtatccttaattg	8	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:46583940C>G	uc002ruv.2	+	4	935	c.447C>G	c.(445-447)CTC>CTG	p.L149L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	149	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACCTGAGTCTCAAAAATGGTA	0.473													0	0	0	1	0	27	46										G	46583940	C	G	46583940	2	3	100	1	0	0	0	0	0	0	0	1	5150	813	29	1		1	EPAS1	2	46583940	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2421957	46583940	196615433	120	30714										
SPTBN1	6711	broad.mit.edu	37	chr2	54883057	54883057	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctttttcatacagatcaagGaaaaattactgcagttgacg	7	7	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:54883057G>T	uc002rxu.2	+	29	6217	c.5968G>T	c.(5968-5970)GAA>TAA	p.E1990*	SPTBN1_uc002rxx.2_Nonsense_Mutation_p.E1977*|SPTBN1_uc002rxy.2_Nonsense_Mutation_p.E135*|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1990	Spectrin 17.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACAGATCAAGGAAAAATTACT	0.393													1	0	0.00136819	1	0.00138729	13	31										T	54883057	G	T	54883057	4	4	100	1	0	0	0	0	0	1	0	0	15118	1175	41	3	6191	3	SPTBN1	2	54883057	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8299117	54883057	188316316	121	30715										
CCDC88A	55704	broad.mit.edu	37	chr2	55559821	55559821	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgggtcttcaacttttcactCaccaaatccttattttaaaa	3	10	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:55559821C>A	uc002ryv.2	-	16	3578	c.2736G>T	c.(2734-2736)GTG>GTT	p.V912V	CCDC88A_uc010yoz.1_Silent_p.V912V|CCDC88A_uc010ypa.1_Silent_p.V912V|CCDC88A_uc002ryu.2_Silent_p.V195V|CCDC88A_uc002ryw.2_Silent_p.V195V	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	912	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						ACTTTTCACTCACCAAATCCT	0.353													1	0	3.07112e-06	1	3.19359e-06	10	80										A	55559821	C	A	55559821	2	1	100	1	0	0	0	0	0	0	0	1	2863	813	29	3		3	CCDC88A	2	55559821	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	676764	55559821	187639552	122	30716										
USP34	9736	broad.mit.edu	37	chr2	61433904	61433904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatgagcaaaccttttctctGaagataagggcgtgtagact	10	7	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:61433904G>C	uc002sbe.2	-	71	9059	c.9037C>G	c.(9037-9039)CAG>GAG	p.Q3013E	USP34_uc002sbd.2_5'Flank	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3013					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCTTTTCTCTGAAGATAAGGG	0.378													0	0	0	1	0	9	48										C	61433904	G	C	61433904	3	2	100	1	0	0	0	0	1	0	0	0	17062	1299	45	1	1643	1	USP34	2	61433904	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5874083	61433904	181765469	123	30717										
C2orf86	51057	broad.mit.edu	37	chr2	63631244	63631244	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgaggaagaggagatcataGatatcactaccttcaccctt	8	10	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:63631244G>A	uc002sch.2	-	10	1820	c.1374C>T	c.(1372-1374)ATC>ATT	p.I458I	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Silent_p.I299I|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Silent_p.I266I|C2orf86_uc002sci.1_Silent_p.I434I|C2orf86_uc010fcr.1_Silent_p.I348I	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	458					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						GGAGATCATAGATATCACTAC	0.393													0	0	0	1	0	113	55										A	63631244	G	A	63631244	2	1	100	1	0	0	0	0	0	0	0	1	2201	932	33	1		1	C2orf86	2	63631244	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2197340	63631244	179568129	124	30718										
UGP2	7360	broad.mit.edu	37	chr2	64112904	64112904	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atatttttgtgtctaacataGataatctgggtgccacagtg	9	6	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:64112904G>C	uc002scm.2	+	6	1063	c.757G>C	c.(757-759)GAT>CAT	p.D253H	UGP2_uc002scl.2_Missense_Mutation_p.D242H|UGP2_uc010ypx.1_Missense_Mutation_p.D262H	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	253		Magnesium (By similarity).			glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						GTCTAACATAGATAATCTGGG	0.388													0	0	0	1	0	31	172										C	64112904	G	C	64112904	3	2	100	1	0	0	0	0	1	0	0	0	16940	942	33	1	779	1	UGP2	2	64112904	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	481660	64112904	179086469	125	30719										
ATP6V1B1	525	broad.mit.edu	37	chr2	71189921	71189921	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccaggatcgagcggatcaTcaccccgcgcctggcgctga	12	16	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:71189921T>C	uc002shj.2	+	9	887	c.800T>C	c.(799-801)ATC>ACC	p.I267T	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.I267T|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.I225T	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	267					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GAGCGGATCATCACCCCGCGC	0.587													0	0	0	1	0	9	116										C	71189921	T	C	71189921	3	2	100	1	0	0	0	0	1	0	0	0	1178	1435	50	5	834	5	ATP6V1B1	2	71189921	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	7077017	71189921	172009452	126	30720										
DYSF	8291	broad.mit.edu	37	chr2	71791217	71791217	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcctgccggacatcgtcatCtggatgctgcagggagacaa	13	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:71791217C>T	uc002sie.2	+	24	2761	c.2385C>T	c.(2383-2385)ATC>ATT	p.I795I	DYSF_uc010feg.2_Silent_p.I826I|DYSF_uc010feh.2_Silent_p.I781I|DYSF_uc002sig.3_Silent_p.I781I|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.I795I|DYSF_uc010fef.2_Silent_p.I812I|DYSF_uc010fei.2_Silent_p.I812I|DYSF_uc010fek.2_Silent_p.I813I|DYSF_uc010fej.2_Silent_p.I782I|DYSF_uc010fel.2_Silent_p.I782I|DYSF_uc010feo.2_Silent_p.I827I|DYSF_uc010fem.2_Silent_p.I796I|DYSF_uc010fen.2_Silent_p.I813I|DYSF_uc002sif.2_Silent_p.I796I	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	795	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ACATCGTCATCTGGATGCTGC	0.642													0	0	0	1	0	28	118										T	71791217	C	T	71791217	2	4	100	1	0	0	0	0	0	0	0	1	4859	903	32	1		1	DYSF	2	71791217	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	601296	71791217	171408156	127	30721										
ALMS1	7840	broad.mit.edu	37	chr2	73675948	73675948	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtacagtctagttcttactCacaaagagaaaagcctagta	7	8	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73675948C>T	uc002sje.1	+	10	2408	c.2297C>T	c.(2296-2298)TCA>TTA	p.S766L	ALMS1_uc002sjf.1_Missense_Mutation_p.S722L|ALMS1_uc002sjg.2_Missense_Mutation_p.S152L|ALMS1_uc002sjh.1_Missense_Mutation_p.S152L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	764	5.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AGTTCTTACTCACAAAGAGAA	0.458													0	0	0	1	0	134	215										T	73675948	C	T	73675948	3	4	100	1	0	0	0	0	1	0	0	0	535	838	29	1	2321	1	ALMS1	2	73675948	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1884731	73675948	169523425	128	30722			1	135		7	7	2913	C		3.255937e-10
ALMS1	7840	broad.mit.edu	37	chr2	73676289	73676289	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcagaccttacccaatagtCatctaactgaagaggctctg	8	11	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73676289C>T	uc002sje.1	+	10	2749	c.2638C>T	c.(2638-2640)CAT>TAT	p.H880Y	ALMS1_uc002sjf.1_Missense_Mutation_p.H836Y|ALMS1_uc002sjg.2_Missense_Mutation_p.H266Y|ALMS1_uc002sjh.1_Missense_Mutation_p.H266Y	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	878	8.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACCCAATAGTCATCTAACTGA	0.478													0	0	0	1	0	54	98										T	73676289	C	T	73676289	3	4	100	1	0	0	0	0	1	0	0	0	535	826	29	1	2662	1	ALMS1	2	73676289	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	341	73676289	169523084	129	30723			1	135		7	7	2913	C		3.255937e-10
ALMS1	7840	broad.mit.edu	37	chr2	73677373	73677373	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccaacctctgcttcttactCacacacagagaagcctggta	6	14	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73677373C>G	uc002sje.1	+	10	3833	c.3722C>G	c.(3721-3723)TCA>TGA	p.S1241*	ALMS1_uc002sjf.1_Nonsense_Mutation_p.S1197*|ALMS1_uc002sjg.2_Nonsense_Mutation_p.S627*|ALMS1_uc002sjh.1_Nonsense_Mutation_p.S627*	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1239	15.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GCTTCTTACTCACACACAGAG	0.473													0	0	0	1	0	70	129										G	73677373	C	G	73677373	4	3	100	1	0	0	0	0	0	1	0	0	535	838	29	1	3746	1	ALMS1	2	73677373	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1084	73677373	169522000	130	30724			1	135		7	7	2913	C		3.255937e-10
ALMS1	7840	broad.mit.edu	37	chr2	73677410	73677410	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtattttctaccaacaggtCttgccagataatcatccaac	6	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73677410C>T	uc002sje.1	+	10	3870	c.3759C>T	c.(3757-3759)GTC>GTT	p.V1253V	ALMS1_uc002sjf.1_Silent_p.V1209V|ALMS1_uc002sjg.2_Silent_p.V639V|ALMS1_uc002sjh.1_Silent_p.V639V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1251	16.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACCAACAGGTCTTGCCAGATA	0.483													0	0	0	1	0	72	114										T	73677410	C	T	73677410	2	4	100	1	0	0	0	0	0	0	0	1	535	900	32	1		1	ALMS1	2	73677410	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	37	73677410	169521963	131	30725			1	135		7	7	2913	C		3.255937e-10
ALMS1	7840	broad.mit.edu	37	chr2	73677968	73677968	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagagaagcctggtagtttCtaccaacaggtcttgccaca	9	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73677968C>G	uc002sje.1	+	10	4428	c.4317C>G	c.(4315-4317)TTC>TTG	p.F1439L	ALMS1_uc002sjf.1_Missense_Mutation_p.F1395L|ALMS1_uc002sjg.2_Missense_Mutation_p.F825L|ALMS1_uc002sjh.1_Missense_Mutation_p.F825L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1437	19.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CTGGTAGTTTCTACCAACAGG	0.488													0	0	0	1	0	107	180										G	73677968	C	G	73677968	3	3	100	1	0	0	0	0	1	0	0	0	535	912	32	1	4341	1	ALMS1	2	73677968	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	558	73677968	169521405	132	30726			1	135		7	7	2913	C		3.255937e-10
ALMS1	7840	broad.mit.edu	37	chr2	73678719	73678719	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtcatttacctgaagaagctCtgaaagttccacctgttcct	7	11	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73678719C>G	uc002sje.1	+	10	5179	c.5068C>G	c.(5068-5070)CTG>GTG	p.L1690V	ALMS1_uc002sjf.1_Missense_Mutation_p.L1646V|ALMS1_uc002sjg.2_Missense_Mutation_p.L1076V|ALMS1_uc002sjh.1_Missense_Mutation_p.L1076V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1688	25.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TGAAGAAGCTCTGAAAGTTCC	0.438													0	0	0	1	0	60	110										G	73678719	C	G	73678719	3	3	100	1	0	0	0	0	1	0	0	0	535	912	32	1	5092	1	ALMS1	2	73678719	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	751	73678719	169520654	133	30727			1	135		7	7	2913	C		3.255937e-10
ALMS1	7840	broad.mit.edu	37	chr2	73678860	73678860	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgagctaactcaagaagctCtgaaagtttcagctgttcct	9	9	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73678860C>G	uc002sje.1	+	10	5320	c.5209C>G	c.(5209-5211)CTG>GTG	p.L1737V	ALMS1_uc002sjf.1_Missense_Mutation_p.L1693V|ALMS1_uc002sjg.2_Missense_Mutation_p.L1123V|ALMS1_uc002sjh.1_Missense_Mutation_p.L1123V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1735	34 X 47 AA approximate tandem repeat.|26.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCAAGAAGCTCTGAAAGTTTC	0.423													0	0	0	1	0	75	120										G	73678860	C	G	73678860	3	3	100	1	0	0	0	0	1	0	0	0	535	912	32	1	5233	1	ALMS1	2	73678860	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	141	73678860	169520513	134	30728			1	135		7	7	2913	C		3.255937e-10
LOXL3	84695	broad.mit.edu	37	chr2	74761668	74761668	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accctctcacccatggcactCgtgccacacccaggagtggc	9	18	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:74761668C>G	uc002smp.1	-	10	1885	c.1813G>C	c.(1813-1815)GAG>CAG	p.E605Q	LOXL3_uc002smo.1_Missense_Mutation_p.E244Q|LOXL3_uc010ffm.1_Missense_Mutation_p.E549Q|LOXL3_uc002smq.1_Missense_Mutation_p.E460Q|LOXL3_uc010ffn.1_Missense_Mutation_p.E460Q	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	605	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CCATGGCACTCGTGCCACACC	0.607													0	0	0	1	0	18	13										G	74761668	C	G	74761668	3	3	100	1	0	0	0	0	1	0	0	0	8901	893	31	1	468	1	LOXL3	2	74761668	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1082808	74761668	168437705	135	30729										
C2orf65	130951	broad.mit.edu	37	chr2	74787419	74787419	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccaggctgtccagcatgctCtgaggaaaagagaggagggg	16	8	1	2	rs77403431		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:74787419C>G	uc002smy.2	-	9	1399	c.1282_splice	c.e9-1	p.S428_splice	C2orf65_uc010ysa.1_Splice_Site_p.S428_splice|C2orf65_uc010ffp.2_Splice_Site_p.S77_splice|C2orf65_uc002smx.2_Splice_Site_p.S184_splice	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951						chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						CCAGCATGCTCTGAGGAAAAG	0.547													0	0	0	1	0	8	52										G	74787419	C	G	74787419	5	3	100	1	0	0	0	0	0	0	1	0	2184	927	32	1	323	1	C2orf65	2	74787419	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	25751	74787419	168411954	136	30730										
LRRTM1	347730	broad.mit.edu	37	chr2	80529574	80529574	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcactgtctgagctgcctGaggctggctgggaaacactt	13	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:80529574G>T	uc002sok.1	-	2	1641	c.1371C>A	c.(1369-1371)CTC>CTA	p.L457L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	457	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TGAGCTGCCTGAGGCTGGCTG	0.557										HNSCC(69;0.2)			1	0	4.36969e-10	1	4.67295e-10	12	80										T	80529574	G	T	80529574	2	4	100	1	0	0	0	0	0	0	0	1	9039	1277	45	3		3	LRRTM1	2	80529574	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5742155	80529574	162669799	137	30731										
POLR1A	25885	broad.mit.edu	37	chr2	86315961	86315961	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccttccagaagagagcaatGagcttgctcttgctctcaca	9	12	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:86315961G>T	uc002sqs.2	-	5	952	c.573C>A	c.(571-573)CTC>CTA	p.L191L	POLR1A_uc002sqv.2_Silent_p.L191L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	191					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGAGAGCAATGAGCTTGCTCT	0.448													1	0	2.35188e-11	1	2.53913e-11	19	91										T	86315961	G	T	86315961	2	4	100	1	0	0	0	0	0	0	0	1	12209	1277	45	3		3	POLR1A	2	86315961	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5786387	86315961	156883412	138	30732										
KDM3A	55818	broad.mit.edu	37	chr2	86718100	86718100	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cattaagaaaacgtcttcatCaagagtatggagttcaaggc	9	7	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:86718100C>G	uc002sri.3	+	24	3997	c.3670C>G	c.(3670-3672)CAA>GAA	p.Q1224E	KDM3A_uc010ytj.1_Missense_Mutation_p.Q1224E|KDM3A_uc010ytk.1_Missense_Mutation_p.Q1172E	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	1224	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						ACGTCTTCATCAAGAGTATGG	0.438													0	0	0	1	0	62	43										G	86718100	C	G	86718100	3	3	100	1	0	0	0	0	1	0	0	0	8126	827	29	1	3760	1	KDM3A	2	86718100	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	402139	86718100	156481273	139	30733										
RNF103	7844	broad.mit.edu	37	chr2	86832071	86832071	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catttacctcgggttgtaatGagcgcaaaaatgaatccatg	9	8	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:86832071G>C	uc002srn.2	-	4	1922	c.953C>G	c.(952-954)TCA>TGA	p.S318*	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Nonsense_Mutation_p.S179*|uc002sro.2_Intron	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	318					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						GGGTTGTAATGAGCGCAAAAA	0.388													0	0	0	1	0	21	122										C	86832071	G	C	86832071	4	2	100	1	0	0	0	0	0	1	0	0	13423	1294	45	1	1108	1	RNF103	2	86832071	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	113971	86832071	156367302	140	30734										
FER1L5	90342	broad.mit.edu	37	chr2	97369274	97369274	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcctagggcaaggtgaagatGagcctggagattctgtcaga	14	7	2	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:97369274G>A	uc010fia.2	+	50	5814	c.5814G>A	c.(5812-5814)ATG>ATA	p.M1938I	FER1L5_uc002sws.3_Missense_Mutation_p.M647I|FER1L5_uc002swt.3_Missense_Mutation_p.M647I|FER1L5_uc010yus.1_Missense_Mutation_p.M646I	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1938						integral to membrane				ovary(1)	1						AGGTGAAGATGAGCCTGGAGA	0.572													0	0	0	1	0	4	57										A	97369274	G	A	97369274	3	1	100	1	0	0	0	0	1	0	0	0	5814	1290	45	1	6012	1	FER1L5	2	97369274	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	10537203	97369274	145830099	141	30735										
CNNM4	26504	broad.mit.edu	37	chr2	97427901	97427901	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actgcttcatgatccgcagcGatgccatcctggacttcaac	8	14	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:97427901G>A	uc002swx.2	+	1	1263	c.1165G>A	c.(1165-1167)GAT>AAT	p.D389N		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	389	CBS 1.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						GATCCGCAGCGATGCCATCCT	0.498													0	0	0	1	0	12	89										A	97427901	G	A	97427901	3	1	100	1	0	0	0	0	1	0	0	0	3615	1058	37	1	1167	1	CNNM4	2	97427901	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	58627	97427901	145771472	142	30736										
ANKRD36	375248	broad.mit.edu	37	chr2	97866080	97866080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgcttttcagtgtcttctcGgaaaaaaccatccttggagg	9	9	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:97866080G>A	uc010yva.1	+	45	3009	c.2765G>A	c.(2764-2766)CGG>CAG	p.R922Q	ANKRD36_uc002sxo.2_Missense_Mutation_p.R338Q|ANKRD36_uc002sxp.3_RNA|ANKRD36_uc002sxq.1_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	922											0						GTGTCTTCTCGGAAAAAACCA	0.338													0	0	0	1	0	13	85										A	97866080	G	A	97866080	3	1	100	1	0	0	0	0	1	0	0	0	665	1116	39	2	2943	2	ANKRD36	2	97866080	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	438179	97866080	145333293	143	30737										
RANBP2	5903	broad.mit.edu	37	chr2	109388219	109388219	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgttctcattgtatatgaaCtaactccaaccgctgagcag	7	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:109388219C>T	uc002tem.3	+	21	8038	c.7912C>T	c.(7912-7914)CTA>TTA	p.L2638L		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2638	Required for E3 SUMO-ligase activity.|1.|Interaction with UBE2I.|2 X 50 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGTATATGAACTAACTCCAAC	0.373													0	0	0	1	0	32	191										T	109388219	C	T	109388219	2	4	100	1	0	0	0	0	0	0	0	1	13028	564	20	2		2	RANBP2	2	109388219	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11522139	109388219	133811154	144	30738										
RABL2A	11159	broad.mit.edu	37	chr2	114399013	114399013	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgtctcggctgctgatggtAccaatgttgtgaaggtgtgg	15	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:114399013A>G	uc002tkn.3	+	7	704	c.490A>G	c.(490-492)ACC>GCC	p.T164A	RABL2A_uc010flb.2_Missense_Mutation_p.T164A|RABL2A_uc002tkl.3_Missense_Mutation_p.T83A|RABL2A_uc002tkm.3_Missense_Mutation_p.T101A|RABL2A_uc002tks.3_Missense_Mutation_p.T165A|RABL2A_uc002tkr.2_Missense_Mutation_p.T165A|RABL2A_uc002tkp.3_Missense_Mutation_p.T165A	NM_007082	NP_009013	Q9UBK7	RBL2A_HUMAN	RAB, member of RAS oncogene family-like 2A	164					small GTPase mediated signal transduction		GTP binding|GTPase activity			skin(1)	1						TGCTGATGGTACCAATGTTGT	0.498													0	0	0	1	0	22	71										G	114399013	A	G	114399013	3	3	100	1	0	0	0	0	1	0	0	0	12970	391	14	5	512	5	RABL2A	2	114399013	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	5010794	114399013	128800360	145	30739										
CNTNAP5	129684	broad.mit.edu	37	chr2	125405445	125405445	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggactacgggggcagcatgGaacagctggaggccgtgatc	17	9	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:125405445G>A	uc002tno.2	+	13	2348	c.1984G>A	c.(1984-1986)GAA>AAA	p.E662K	CNTNAP5_uc010flu.2_Missense_Mutation_p.E663K	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	662	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGGCAGCATGGAACAGCTGGA	0.627													0	0	0	1	0	4	11										A	125405445	G	A	125405445	3	1	100	1	0	0	0	0	1	0	0	0	3650	1175	41	1	2034	1	CNTNAP5	2	125405445	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	11006432	125405445	117793928	146	30740										
ERCC3	2071	broad.mit.edu	37	chr2	128016992	128016992	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttgtcgaaaacgccaagtcTtcctcctccatgccagcgag	8	14	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:128016992T>C	uc002toh.1	-	14	2192	c.2097A>G	c.(2095-2097)GAA>GAG	p.E699E	ERCC3_uc002toe.1_Silent_p.E454E|ERCC3_uc002tof.1_Silent_p.E635E|ERCC3_uc002tog.1_Silent_p.E635E	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	699	Asp/Glu-rich (acidic).|Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		ACGCCAAGTCTTCCTCCTCCA	0.572			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	39	66										C	128016992	T	C	128016992	2	2	100	1	0	0	0	0	0	0	0	1	5214	1606	56	5		5	ERCC3	2	128016992	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	2611547	128016992	115182381	147	30741										
MYO7B	4648	broad.mit.edu	37	chr2	128367562	128367562	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgggcagggagcacggtgccCaggttccacagcacagtaga	15	11	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:128367562C>G	uc002top.2	+	24	3216	c.3163C>G	c.(3163-3165)CAG>GAG	p.Q1055E		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1055	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCACGGTGCCCAGGTTCCACA	0.657													0	0	0	1	0	5	11										G	128367562	C	G	128367562	3	3	100	1	0	0	0	0	1	0	0	0	10083	595	21	4	3253	4	MYO7B	2	128367562	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	350570	128367562	114831811	148	30742										
NCKAP5	344148	broad.mit.edu	37	chr2	133542301	133542301	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agttgaattgatggaaatctCatttctggtaacagtgacaa	9	5	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:133542301C>A	uc002ttp.2	-	14	2457	c.2083G>T	c.(2083-2085)GAG>TAG	p.E695*	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	695							protein binding				0						ATGGAAATCTCATTTCTGGTA	0.458													1	0	1.17739e-12	1	1.28065e-12	25	111										A	133542301	C	A	133542301	4	1	100	1	0	0	0	0	0	1	0	0	10223	835	29	3	3674	3	NCKAP5	2	133542301	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5174739	133542301	109657072	149	30743										
MCM6	4175	broad.mit.edu	37	chr2	136603845	136603845	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtgaagcacaataaggttaGagattcggcagtactcagag	13	6	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:136603845G>C	uc002tuw.2	-	15	2247	c.2171C>G	c.(2170-2172)TCT>TGT	p.S724C		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	724					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	AATAAGGTTAGAGATTCGGCA	0.483													0	0	0	1	0	55	38										C	136603845	G	C	136603845	3	2	100	1	0	0	0	0	1	0	0	0	9391	942	33	1	306	1	MCM6	2	136603845	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3061544	136603845	106595528	150	30744										
EPC2	26122	broad.mit.edu	37	chr2	149528807	149528807	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcaatatcagatcatgtcGactacagtgtttccagccaa	7	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:149528807G>A	uc010zbt.1	+	10	1598	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	524					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		AGATCATGTCGACTACAGTGT	0.368													0	0	0	1	0	72	41										A	149528807	G	A	149528807	3	1	100	1	0	0	0	0	1	0	0	0	5161	1058	37	1	1609	1	EPC2	2	149528807	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	12924962	149528807	93670566	151	30745										
NEB	4703	broad.mit.edu	37	chr2	152477516	152477516	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atagccttctttcttggcttCttccatggcctgacgataga	8	11	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:152477516C>G	uc010fnx.2	-	68	9939	c.9748G>C	c.(9748-9750)GAA>CAA	p.E3250Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3250	Nebulin 88.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTGGCTTCTTCCATGGCC	0.438													0	0	0	1	0	11	12										G	152477516	C	G	152477516	3	3	100	1	0	0	0	0	1	0	0	0	10302	922	32	1	15653	1	NEB	2	152477516	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2948709	152477516	90721857	152	30746										
CACNB4	785	broad.mit.edu	37	chr2	152728976	152728976	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtcccagataccatttctcCaagacttgaagaagaatttc	6	10	1	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:152728976C>G	uc002tya.2	-	6	621	c.553G>C	c.(553-555)GGA>CGA	p.G185R	CACNB4_uc002txy.2_Missense_Mutation_p.G151R|CACNB4_uc002txz.2_Missense_Mutation_p.G167R|CACNB4_uc010fnz.2_Missense_Mutation_p.G185R|CACNB4_uc002tyb.2_Missense_Mutation_p.G151R	NM_000726	NP_000717	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4	185					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	ACCATTTCTCCAAGACTTGAA	0.358													0	0	0	1	0	13	102										G	152728976	C	G	152728976	3	3	100	1	0	0	0	0	1	0	0	0	2555	603	21	4	1045	4	CACNB4	2	152728976	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	251460	152728976	90470397	153	30747										
GPD2	2820	broad.mit.edu	37	chr2	157407191	157407191	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actctgtgcgcaaaatggatGataaagacgcagcagctatc	10	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:157407191G>A	uc002tzf.3	+	8	1264	c.904G>A	c.(904-906)GAT>AAT	p.D302N	GPD2_uc010zch.1_Missense_Mutation_p.D75N|GPD2_uc002tzd.3_Missense_Mutation_p.D302N|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	302					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						CAAAATGGATGATAAAGACGC	0.473													0	0	0	1	0	51	109										A	157407191	G	A	157407191	3	1	100	1	0	0	0	0	1	0	0	0	6606	1290	45	1	930	1	GPD2	2	157407191	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4678215	157407191	85792182	154	30748										
TANC1	85461	broad.mit.edu	37	chr2	160027154	160027154	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggctctttcaccagatagaaGaaaacttgaggaacacagaa	9	8	2	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:160027154G>T	uc002uag.2	+	10	1463	c.1189G>T	c.(1189-1191)GAA>TAA	p.E397*	TANC1_uc010fol.1_Nonsense_Mutation_p.E291*|TANC1_uc010zcm.1_Nonsense_Mutation_p.E389*|TANC1_uc010fom.1_Nonsense_Mutation_p.E203*	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	397						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCAGATAGAAGAAAACTTGAG	0.468													1	0	7.21436e-19	1	8.04496e-19	21	119										T	160027154	G	T	160027154	4	4	100	1	0	0	0	0	0	1	0	0	15541	943	33	3	1219	3	TANC1	2	160027154	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2619963	160027154	83172219	155	30749										
PLA2R1	22925	broad.mit.edu	37	chr2	160801453	160801453	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tataaagccttttttttcttGacacggggatagctgccata	8	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:160801453G>C	uc002ube.1	-	28	4315	c.4108C>G	c.(4108-4110)CAA>GAA	p.Q1370E	PLA2R1_uc010zcp.1_Missense_Mutation_p.Q1368E	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1370	Extracellular (Potential).|C-type lectin 8.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTTTTTTCTTGACACGGGGAT	0.423													0	0	0	1	0	33	297										C	160801453	G	C	160801453	3	2	100	1	0	0	0	0	1	0	0	0	12010	1299	45	1	295	1	PLA2R1	2	160801453	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	774299	160801453	82397920	156	30750										
SLC4A10	57282	broad.mit.edu	37	chr2	162830786	162830786	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagtatgctagctatggaaGatgagggcacagtacaactc	11	7	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:162830786G>C	uc002ubx.3	+	24	3371	c.3187G>C	c.(3187-3189)GAT>CAT	p.D1063H	SLC4A10_uc002uby.3_Missense_Mutation_p.D1033H|SLC4A10_uc010zcs.1_Missense_Mutation_p.D1044H	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	1063	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						AGCTATGGAAGATGAGGGCAC	0.323													0	0	0	1	0	3	27										C	162830786	G	C	162830786	3	2	100	1	0	0	0	0	1	0	0	0	14651	942	33	1	3366	1	SLC4A10	2	162830786	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2029333	162830786	80368587	157	30751										
SCN7A	6332	broad.mit.edu	37	chr2	167313506	167313506	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atggcaagtatgcctaagaaCaaacttgccatataaaagga	8	7	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:167313506C>A	uc002udu.1	-	10	1291	c.1164G>T	c.(1162-1164)TTG>TTT	p.L388F	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	388	Helical; Name=S6 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TGCCTAAGAACAAACTTGCCA	0.348													1	0	0.115264	1	0.115264	3	21										A	167313506	C	A	167313506	3	1	100	1	0	0	0	0	1	0	0	0	13923	477	17	4	3948	4	SCN7A	2	167313506	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4482720	167313506	75885867	158	30752										
LRP2	4036	broad.mit.edu	37	chr2	170050365	170050365	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgcacctcccaccatcacaCttgaactcatcagctaggca	5	16	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:170050365C>T	uc002ues.2	-	47	8949	c.8736G>A	c.(8734-8736)AAG>AAA	p.K2912K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2912	LDL-receptor class A 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACCATCACACTTGAACTCAT	0.463													0	0	0	1	0	29	134										T	170050365	C	T	170050365	2	4	100	1	0	0	0	0	0	0	0	1	8956	564	20	2		2	LRP2	2	170050365	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2736859	170050365	73149008	159	30753										
RAPGEF4	11069	broad.mit.edu	37	chr2	173891907	173891907	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttaatgaaattcagttttgGgtcgtcactgagatctgcct	9	7	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:173891907G>T	uc002uhv.3	+	25	2665	c.2478G>T	c.(2476-2478)TGG>TGT	p.W826C	RAPGEF4_uc002uhw.3_Missense_Mutation_p.W682C	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	826	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTCAGTTTTGGGTCGTCACTG	0.373													1	0	1.20869e-33	1	1.36582e-33	59	7										T	173891907	G	T	173891907	3	4	100	1	0	0	0	0	1	0	0	0	13046	1241	43	4	2592	4	RAPGEF4	2	173891907	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3841542	173891907	69307466	160	30754										
PDE11A	50940	broad.mit.edu	37	chr2	178705092	178705092	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagtcggagtatgatgatttCtccatgctttctttgaaact	8	8	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:178705092C>T	uc002ulq.2	-	6	1704	c.1386G>A	c.(1384-1386)GAG>GAA	p.E462E	PDE11A_uc002ulp.2_Silent_p.E18E|PDE11A_uc002ulr.2_Silent_p.E212E|PDE11A_uc002uls.1_Silent_p.E104E|PDE11A_uc002ult.1_Silent_p.E212E|PDE11A_uc002ulu.1_Silent_p.E104E	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	462	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			ATGATGATTTCTCCATGCTTT	0.423									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	1	0	69	1										T	178705092	C	T	178705092	2	4	100	1	0	0	0	0	0	0	0	1	11631	912	32	1		1	PDE11A	2	178705092	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4813185	178705092	64494281	161	30755										
PLEKHA3	65977	broad.mit.edu	37	chr2	179360322	179360322	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaatgccaagtttaaacctGagatgtttcaactgcaccat	6	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179360322G>C	uc002umn.2	+	5	948	c.550G>C	c.(550-552)GAG>CAG	p.E184Q		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	184						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			GTTTAAACCTGAGATGTTTCA	0.428													0	0	0	1	0	22	146										C	179360322	G	C	179360322	3	2	100	1	0	0	0	0	1	0	0	0	12057	1291	45	1	568	1	PLEKHA3	2	179360322	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	655230	179360322	63839051	162	30756										
TTN	7273	broad.mit.edu	37	chr2	179413724	179413724	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gactgtatatcttgttttcaCacatgcctctgcattcacct	5	12	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179413724C>T	uc010zfg.1	-	288	85149	c.84925G>A	c.(84925-84927)GTG>ATG	p.V28309M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V22004M|TTN_uc010zfi.1_Missense_Mutation_p.V21937M|TTN_uc010zfj.1_Missense_Mutation_p.V21812M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29236							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGTTTTCACACATGCCTCT	0.423													0	0	0	1	0	49	41										T	179413724	C	T	179413724	3	4	100	1	0	0	0	0	1	0	0	0	16732	478	17	2	15446	2	TTN	2	179413724	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	53402	179413724	63785649	163	30757										
TTN	7273	broad.mit.edu	37	chr2	179435376	179435376	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctggtggcaaagtcggtgctCtttatttctaatcgagctgt	11	8	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179435376C>G	uc010zfg.1	-	275	68003	c.67779G>C	c.(67777-67779)AAG>AAC	p.K22593N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K16288N|TTN_uc010zfi.1_Missense_Mutation_p.K16221N|TTN_uc010zfj.1_Missense_Mutation_p.K16096N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23520							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCGGTGCTCTTTATTTCTA	0.413													0	0	0	1	0	17	80										G	179435376	C	G	179435376	3	3	100	1	0	0	0	0	1	0	0	0	16732	912	32	1	32644	1	TTN	2	179435376	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	21652	179435376	63763997	164	30758										
TTN	7273	broad.mit.edu	37	chr2	179514605	179514605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcttctctgggatgatcttCttgggctcttcaggcacttg	10	10	6	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179514605C>G	uc010zfg.1	-	165	32756	c.32532G>C	c.(32530-32532)AAG>AAC	p.K10844N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_RNA|TTN_uc002umx.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11771							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATGATCTTCTTGGGCTCTT	0.338													0	0	0	1	0	41	78										G	179514605	C	G	179514605	3	3	100	1	0	0	0	0	1	0	0	0	16732	912	32	1	68045	1	TTN	2	179514605	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	79229	179514605	63684768	165	30759										
NCKAP1	10787	broad.mit.edu	37	chr2	183817172	183817172	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgaaatatgccacataagGctttcacttagaaacttcat	6	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:183817172G>T	uc002upc.2	-	23	2964	c.2562C>A	c.(2560-2562)AGC>AGA	p.S854R	NCKAP1_uc002upb.2_Missense_Mutation_p.S860R	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	854					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GCCACATAAGGCTTTCACTTA	0.313													1	0	8.00594e-06	1	8.29128e-06	19	63										T	183817172	G	T	183817172	3	4	100	1	0	0	0	0	1	0	0	0	10221	1194	42	4	860	4	NCKAP1	2	183817172	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4302567	183817172	59382201	166	30760										
SF3B1	23451	broad.mit.edu	37	chr2	198257718	198257718	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtaaacaatattgcaacattCtacatggtccaatagcaact	5	9	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:198257718C>G	uc002uue.2	-	24	3782	c.3734G>C	c.(3733-3735)AGA>ACA	p.R1245T		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	1245					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTGCAACATTCTACATGGTCC	0.294													0	0	0	1	0	5	32										G	198257718	C	G	198257718	3	3	100	1	0	0	0	0	1	0	0	0	14149	913	32	1	188	1	SF3B1	2	198257718	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	14440546	198257718	44941655	167	30761										
KCTD18	130535	broad.mit.edu	37	chr2	201369515	201369515	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	taaagaatatgtctccatttCattggccaaatggtcagaca	7	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:201369515C>T	uc002uvs.2	-	3	845	c.328G>A	c.(328-330)GAA>AAA	p.E110K	KCTD18_uc002uvt.2_Missense_Mutation_p.E110K|KCTD18_uc002uvu.1_Missense_Mutation_p.E110K	NM_152387	NP_689600	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain	110						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1						GTCTCCATTTCATTGGCCAAA	0.373													0	0	0	1	0	7	30										T	201369515	C	T	201369515	3	4	100	1	0	0	0	0	1	0	0	0	8105	835	29	1	972	1	KCTD18	2	201369515	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3111797	201369515	41829858	168	30762										
TRAK2	66008	broad.mit.edu	37	chr2	202251049	202251049	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggttgctgaacctgaaaagTaataccctcctcttcatcct	6	12	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:202251049T>C	uc002uyb.3	-	14	2301	c.1855A>G	c.(1855-1857)ACT>GCT	p.T619A		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	619				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						ACCTGAAAAGTAATACCCTCC	0.463													0	0	0	1	0	9	69										C	202251049	T	C	202251049	3	2	100	1	0	0	0	0	1	0	0	0	16447	1638	57	5	901	5	TRAK2	2	202251049	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	881534	202251049	40948324	169	30763										
NRP2	8828	broad.mit.edu	37	chr2	206659622	206659622	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagctcactgggcgtcctccTgggggccacctgtgcaggcc	15	15	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:206659622T>C	uc002vaw.2	+	17	3427	c.2636T>C	c.(2635-2637)CTG>CCG	p.L879P	NRP2_uc002vax.2_Missense_Mutation_p.L874P|NRP2_uc002vay.2_Missense_Mutation_p.L857P	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	879	Helical; (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGCGTCCTCCTGGGGGCCACC	0.612													0	0	0	1	0	25	27										C	206659622	T	C	206659622	3	2	100	1	0	0	0	0	1	0	0	0	10661	1580	55	5	3014	5	NRP2	2	206659622	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	4408573	206659622	36539751	170	30764										
MDH1B	130752	broad.mit.edu	37	chr2	207621668	207621668	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgcaagttttcagggcttCttcctcctgctctttttcta	7	11	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:207621668C>A	uc002vbs.2	-	4	422	c.367G>T	c.(367-369)GAA>TAA	p.E123*	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Nonsense_Mutation_p.E123*|MDH1B_uc010fuj.2_Nonsense_Mutation_p.E25*|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	123					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TTCAGGGCTTCTTCCTCCTGC	0.428													1	0	2.80697e-09	1	2.97985e-09	10	28										A	207621668	C	A	207621668	4	1	100	1	0	0	0	0	0	1	0	0	9409	922	32	3	1225	3	MDH1B	2	207621668	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	962046	207621668	35577705	171	30765										
ERBB4	2066	broad.mit.edu	37	chr2	212248420	212248420	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggagaactcagagaggtattCaggattctctgccacaatag	11	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:212248420C>G	uc002veg.1	-	28	3945	c.3847G>C	c.(3847-3849)GAA>CAA	p.E1283Q	ERBB4_uc002veh.1_Missense_Mutation_p.E1267Q|ERBB4_uc010zji.1_Missense_Mutation_p.E1273Q|ERBB4_uc010zjj.1_Missense_Mutation_p.E1257Q	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1283	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GAGAGGTATTCAGGATTCTCT	0.502										TSP Lung(8;0.080)			0	0	0	1	0	11	31										G	212248420	C	G	212248420	3	3	100	1	0	0	0	0	1	0	0	0	5209	835	29	1	83	1	ERBB4	2	212248420	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4626752	212248420	30950953	172	30766										
STK36	27148	broad.mit.edu	37	chr2	219544719	219544719	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggggccactcctcaggaatCaagcctcctggccgggatct	12	15	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:219544719C>G	uc002viu.2	+	9	1318	c.1052C>G	c.(1051-1053)TCA>TGA	p.S351*	STK36_uc002viv.2_Nonsense_Mutation_p.S351*	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	351					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CCTCAGGAATCAAGCCTCCTG	0.587													0	0	0	1	0	21	34										G	219544719	C	G	219544719	4	3	100	1	0	0	0	0	0	1	0	0	15301	838	29	1	1082	1	STK36	2	219544719	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	7296299	219544719	23654654	173	30767										
CCDC108	255101	broad.mit.edu	37	chr2	219870931	219870931	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgacagactgctggttcttGatgggaggcagtgtctttgg	15	7	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:219870931G>C	uc002vjl.1	-	31	4818	c.4734C>G	c.(4732-4734)ATC>ATG	p.I1578M		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1578						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGGTTCTTGATGGGAGGCA	0.607													0	0	0	1	0	38	8										C	219870931	G	C	219870931	3	2	100	1	0	0	0	0	1	0	0	0	2743	1280	45	1	1063	1	CCDC108	2	219870931	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	326212	219870931	23328442	174	30768										
SLC16A14	151473	broad.mit.edu	37	chr2	230911034	230911034	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gttcttcctgtgcccggcctGatcggggcactcctgggctt	13	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:230911034G>C	uc002vqd.1	-	4	1171	c.808C>G	c.(808-810)CAG>GAG	p.Q270E	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.Q270E|SLC16A14_uc002vqf.2_Missense_Mutation_p.Q270E	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	270	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TGCCCGGCCTGATCGGGGCAC	0.587													0	0	0	1	0	54	9										C	230911034	G	C	230911034	3	2	100	1	0	0	0	0	1	0	0	0	14407	1299	45	1	732	1	SLC16A14	2	230911034	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	11040103	230911034	12288339	175	30769										
INPP5D	3635	broad.mit.edu	37	chr2	234072504	234072504	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagaaggagtggctggagatCctcaaacactccctgcaaga	12	10	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:234072504C>T	uc010zmo.1	+	11	1545	c.1392C>T	c.(1390-1392)ATC>ATT	p.I464I	INPP5D_uc010zmp.1_Silent_p.I463I	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	464					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GGCTGGAGATCCTCAAACACT	0.552													0	0	0	1	0	31	6										T	234072504	C	T	234072504	2	4	100	1	0	0	0	0	0	0	0	1	7756	845	30	1		1	INPP5D	2	234072504	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3161470	234072504	9126869	176	30770										
HJURP	55355	broad.mit.edu	37	chr2	234749322	234749322	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacggtgttgtccaccccatCtgaggcacccagggaattgc	12	13	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:234749322C>G	uc002vvg.2	-	8	2170	c.2104G>C	c.(2104-2106)GAT>CAT	p.D702H	HJURP_uc010znd.1_Missense_Mutation_p.D641H|HJURP_uc010zne.1_Missense_Mutation_p.D610H	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	702					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TCCACCCCATCTGAGGCACCC	0.577													0	0	0	1	0	28	36										G	234749322	C	G	234749322	3	3	100	1	0	0	0	0	1	0	0	0	7189	913	32	1	150	1	HJURP	2	234749322	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	676818	234749322	8450051	177	30771										
SNED1	25992	broad.mit.edu	37	chr2	242004846	242004846	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggtcacctacgtctcctccGacggctcctaccgccgcaca	8	20	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:242004846G>A	uc002wah.1	+	21	2845	c.2845G>A	c.(2845-2847)GAC>AAC	p.D949N	SNED1_uc002wai.1_Missense_Mutation_p.D184N|SNED1_uc002waj.1_Missense_Mutation_p.D36N|SNED1_uc002wak.2_Missense_Mutation_p.D36N	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	949	Fibronectin type-III 1.				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CGTCTCCTCCGACGGCTCCTA	0.647													0	0	0	1	0	11	20										A	242004846	G	A	242004846	3	1	100	1	0	0	0	0	1	0	0	0	14845	1058	37	1	2927	1	SNED1	2	242004846	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7255524	242004846	1194527	178	30772										
LRRN1	57633	broad.mit.edu	37	chr3	3887605	3887605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagtgcctcccaatgatatCtcacgacagcttcccaaatc	5	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:3887605C>G	uc003bpt.3	+	2	2041	c.1280C>G	c.(1279-1281)TCT>TGT	p.S427C	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	427	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCAATGATATCTCACGACAGC	0.502													0	0	0	1	0	53	66										G	3887605	C	G	3887605	3	3	100	1	0	0	0	0	1	0	0	0	9034	913	32	1	1282	1	LRRN1	3	3887605	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		3887605	194134825	179	30773										
SUMF1	285362	broad.mit.edu	37	chr3	4508701	4508701	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctctccgggtacggggcccgGagcgttagcctcccgcgagt	15	15	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:4508701G>C	uc003bpz.1	-	1	254	c.229C>G	c.(229-231)CCG>GCG	p.P77A	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Missense_Mutation_p.P77A|SUMF1_uc010hby.1_Missense_Mutation_p.P77A|SUMF1_uc011ast.1_Missense_Mutation_p.P77A	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	77						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		ACGGGGCCCGGAGCGTTAGCC	0.706													0	0	0	1	0	3	9										C	4508701	G	C	4508701	3	2	100	1	0	0	0	0	1	0	0	0	15382	1174	41	1	931	1	SUMF1	3	4508701	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	621096	4508701	193513729	180	30774										
ITPR1	3708	broad.mit.edu	37	chr3	4842241	4842241	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aattctacgactgatattttCagtcgggttacaacccacgt	7	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:4842241C>T	uc003bqa.2	+	51	7268	c.6920C>T	c.(6919-6921)TCA>TTA	p.S2307L	ITPR1_uc010hca.1_Missense_Mutation_p.S2292L|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.S1277L|ITPR1_uc010hcc.1_Missense_Mutation_p.S75L|ITPR1_uc011asv.1_Missense_Mutation_p.S31L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2355	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGATATTTTCAGTCGGGTTA	0.483													0	0	0	1	0	17	61										T	4842241	C	T	4842241	3	4	100	1	0	0	0	0	1	0	0	0	7920	838	29	1	7270	1	ITPR1	3	4842241	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	333540	4842241	193180189	181	30775										
ITPR1	3708	broad.mit.edu	37	chr3	4856165	4856165	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacacatgtgagacgctgctGatgtgcattgtcactgtgct	11	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:4856165G>T	uc003bqa.2	+	55	7824	c.7476G>T	c.(7474-7476)CTG>CTT	p.L2492L	ITPR1_uc010hca.1_Silent_p.L2477L|ITPR1_uc011asu.1_Silent_p.L503L|ITPR1_uc003bqc.2_Silent_p.L1462L|ITPR1_uc010hcc.1_Silent_p.L260L|ITPR1_uc011asv.1_Silent_p.L216L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2540	Lumenal (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGACGCTGCTGATGTGCATTG	0.537													1	0	1.30897e-18	1	1.45808e-18	31	71										T	4856165	G	T	4856165	2	4	100	1	0	0	0	0	0	0	0	1	7920	1277	45	3		3	ITPR1	3	4856165	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	13924	4856165	193166265	182	30776										
EDEM1	9695	broad.mit.edu	37	chr3	5241290	5241290	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttaaagataatgggaaattCatccgagttccagaaagccg	9	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:5241290C>T	uc003bqi.2	+	3	728	c.596C>T	c.(595-597)TCA>TTA	p.S199L	EDEM1_uc011asz.1_Intron|EDEM1_uc003bqh.2_Missense_Mutation_p.S199L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	199	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		ATGGGAAATTCATCCGAGTTC	0.408													0	0	0	1	0	28	28										T	5241290	C	T	5241290	3	4	100	1	0	0	0	0	1	0	0	0	4911	838	29	1	606	1	EDEM1	3	5241290	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	385125	5241290	192781140	183	30777										
MKRN2	23609	broad.mit.edu	37	chr3	12611602	12611602	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggccctctgctgcagctgGaggtgctgtgggcaccatgg	17	11	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:12611602G>C	uc003bxd.2	+	3	244	c.188G>C	c.(187-189)GGA>GCA	p.G63A	MKRN2_uc003bxe.2_Missense_Mutation_p.G61A|MKRN2_uc011aus.1_Missense_Mutation_p.G20A	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	63						intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						GCTGCAGCTGGAGGTGCTGTG	0.547													0	0	0	1	0	23	73										C	12611602	G	C	12611602	3	2	100	1	0	0	0	0	1	0	0	0	9607	1174	41	1	198	1	MKRN2	3	12611602	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7370312	12611602	185410828	184	30778										
TRIM71	131405	broad.mit.edu	37	chr3	32932040	32932040	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggagctgaagaccgtgcgGagcctcctgcagccccagga	14	14	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:32932040G>A	uc003cff.2	+	4	1407	c.1344G>A	c.(1342-1344)CGG>CGA	p.R448R		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	448					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						AGACCGTGCGGAGCCTCCTGC	0.617													0	0	0	1	0	27	43										A	32932040	G	A	32932040	2	1	100	1	0	0	0	0	0	0	0	1	16541	1161	41	1		1	TRIM71	3	32932040	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	20320438	32932040	165090390	185	30779										
GLB1	2720	broad.mit.edu	37	chr3	33109743	33109743	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgggtcggaggagcggagaaGaatagactctttctctagca	14	7	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:33109743G>C	uc003cfi.1	-	4	553	c.436C>G	c.(436-438)CTT>GTT	p.L146V	GLB1_uc003cfh.1_Missense_Mutation_p.L116V|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Missense_Mutation_p.L194V	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	146					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				GAGCGGAGAAGAATAGACTCT	0.383													0	0	0	1	0	13	39										C	33109743	G	C	33109743	3	2	100	1	0	0	0	0	1	0	0	0	6427	942	33	1	1649	1	GLB1	3	33109743	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	177703	33109743	164912687	186	30780										
CLASP2	23122	broad.mit.edu	37	chr3	33614798	33614798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcatcgctgttggcgtcatCatctgaatgcattccatatg	9	10	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:33614798C>G	uc003cfu.2	-	25	2857	c.2503G>C	c.(2503-2505)GAT>CAT	p.D835H	CLASP2_uc003cfs.2_Missense_Mutation_p.D43H|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.D436H	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	844										ovary(3)|central_nervous_system(1)	4						TTGGCGTCATCATCTGAATGC	0.393													0	0	0	1	0	32	54										G	33614798	C	G	33614798	3	3	100	1	0	0	0	0	1	0	0	0	3455	826	29	1	2073	1	CLASP2	3	33614798	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	505055	33614798	164407632	187	30781										
MLH1	4292	broad.mit.edu	37	chr3	37035095	37035095	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagacagtggtgaaccgcatCgcggcgggggaagttatcca	16	9	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:37035095C>T	uc003cgl.2	+	1	117	c.57C>T	c.(55-57)ATC>ATT	p.I19I	MLH1_uc011aye.1_5'Flank|EPM2AIP1_uc003cgk.2_5'Flank|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Silent_p.I19I|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	19			I -> F (in HNPCC2; uncertain pathogenicity).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TGAACCGCATCGCGGCGGGGG	0.567		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	1	0	15	34										T	37035095	C	T	37035095	2	4	100	1	0	0	0	0	0	0	0	1	9617	874	31	1		1	MLH1	3	37035095	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3420297	37035095	160987335	188	30782										
GOLGA4	2803	broad.mit.edu	37	chr3	37368570	37368570	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gattcccaaggctgtgtgcaGaagacatatgaagaaaaaat	10	6	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:37368570G>A	uc003cgv.2	+	14	5497	c.5193G>A	c.(5191-5193)CAG>CAA	p.Q1731Q	GOLGA4_uc010hgr.1_Silent_p.Q1292Q|GOLGA4_uc003cgw.2_Silent_p.Q1753Q|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Silent_p.Q1612Q	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1731	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GCTGTGTGCAGAAGACATATG	0.373													0	0	0	1	0	39	104										A	37368570	G	A	37368570	2	1	100	1	0	0	0	0	0	0	0	1	6555	933	33	1		1	GOLGA4	3	37368570	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	333475	37368570	160653860	189	30783										
OXSR1	9943	broad.mit.edu	37	chr3	38292922	38292922	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagggtgtctctcaggaactCatttctgctggcctggtcga	13	10	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:38292922C>G	uc003chy.2	+	16	1746	c.1404C>G	c.(1402-1404)CTC>CTG	p.L468L	OXSR1_uc010hhb.2_Silent_p.L402L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	468					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CTCAGGAACTCATTTCTGCTG	0.468													0	0	0	1	0	48	138										G	38292922	C	G	38292922	2	3	100	1	0	0	0	0	0	0	0	1	11336	813	29	1		1	OXSR1	3	38292922	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	924352	38292922	159729508	190	30784										
TTC21A	199223	broad.mit.edu	37	chr3	39166841	39166841	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggtgctaattttcctccaaGccctcctgatgtccaggaag	9	12	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:39166841G>T	uc003cjc.2	+	11	1411	c.1234G>T	c.(1234-1236)GCC>TCC	p.A412S	TTC21A_uc003cje.2_Missense_Mutation_p.A412S|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.A363S	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	412							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTTCCTCCAAGCCCTCCTGAT	0.562											OREG0015487	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.75199e-13	1	1.90972e-13	29	28										T	39166841	G	T	39166841	3	4	100	1	0	0	0	0	1	0	0	0	16684	971	34	4	1276	4	TTC21A	3	39166841	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	873919	39166841	158855589	191	30785										
CX3CR1	1524	broad.mit.edu	37	chr3	39307166	39307166	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atggctaaatgcaaccgtctCagtcacactgagggccagcc	10	13	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:39307166C>T	uc003cjl.2	-	2	927	c.835G>A	c.(835-837)GAG>AAG	p.E279K		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	279	Helical; Name=7; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GCAACCGTCTCAGTCACACTG	0.468													0	0	0	1	0	39	74										T	39307166	C	T	39307166	3	4	100	1	0	0	0	0	1	0	0	0	4075	835	29	1	236	1	CX3CR1	3	39307166	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	140325	39307166	158715264	192	30786										
CCR8	1237	broad.mit.edu	37	chr3	39374656	39374656	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtagcataagccaacagctGacttatgccacccatgtcac	7	13	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:39374656G>A	uc010hhr.2	+	2	972	c.834G>A	c.(832-834)CTG>CTA	p.L278L	CCR8_uc003cjm.2_Silent_p.L195L	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	278	Extracellular (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GCCAACAGCTGACTTATGCCA	0.433													0	0	0	1	0	26	30										A	39374656	G	A	39374656	2	1	100	1	0	0	0	0	0	0	0	1	2947	1277	45	1		1	CCR8	3	39374656	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	67490	39374656	158647774	193	30787										
NKTR	4820	broad.mit.edu	37	chr3	42687461	42687461	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagtgagagcagcagataCagttgaaaacgtccggatac	11	10	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:42687461C>T	uc003clo.2	+	17	4530	c.4383C>T	c.(4381-4383)TAC>TAT	p.Y1461Y	NKTR_uc003clp.2_Silent_p.Y1209Y|NKTR_uc011azp.1_Missense_Mutation_p.T272I|NKTR_uc003cls.2_Silent_p.Y1161Y	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1461					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GCAGCAGATACAGTTGAAAAC	0.373													0	0	0	1	0	5	17										T	42687461	C	T	42687461	2	4	100	1	0	0	0	0	0	0	0	1	10448	489	17	2		2	NKTR	3	42687461	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3312805	42687461	155334969	194	30788										
CCDC13	152206	broad.mit.edu	37	chr3	42793446	42793446	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accaatgctctgtctcccatCtgggccctcggtggcttggc	11	15	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:42793446C>G	uc003cly.3	-	5	669	c.585G>C	c.(583-585)CAG>CAC	p.Q195H	CCDC13_uc003clz.2_Missense_Mutation_p.Q195H|CCDC13_uc011azq.1_Missense_Mutation_p.Q195H	NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	195	Potential.									ovary(1)	1						TGTCTCCCATCTGGGCCCTCG	0.592													0	0	0	1	0	6	22										G	42793446	C	G	42793446	3	3	100	1	0	0	0	0	1	0	0	0	2765	912	32	1	1610	1	CCDC13	3	42793446	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	105985	42793446	155228984	195	30789										
CYP8B1	1582	broad.mit.edu	37	chr3	42916916	42916916	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccttcaagccatcccccctCagatgcttggtgctggctga	9	15	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:42916916C>G	uc003cmh.2	-	1	718	c.393G>C	c.(391-393)CTG>CTC	p.L131L	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Silent_p.L131L	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	131					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CATCCCCCCTCAGATGCTTGG	0.502													0	0	0	1	0	21	54										G	42916916	C	G	42916916	2	3	100	1	0	0	0	0	0	0	0	1	4198	813	29	1		1	CYP8B1	3	42916916	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	123470	42916916	155105514	196	30790										
SETD2	29072	broad.mit.edu	37	chr3	47098400	47098400	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgataatatatggttgcttGagactgtgcaggagagtact	12	4	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:47098400G>C	uc003cqs.2	-	15	6927	c.6874C>G	c.(6874-6876)CAA>GAA	p.Q2292E	SETD2_uc003cqv.2_Missense_Mutation_p.Q2359E	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2292	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATGGTTGCTTGAGACTGTGCA	0.463			N|F|S|Mis		clear cell renal carcinoma								0	0	0	1	0	23	20										C	47098400	G	C	47098400	3	2	100	1	0	0	0	0	1	0	0	0	14131	1299	45	1	848	1	SETD2	3	47098400	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4181484	47098400	150924030	197	30791										
C3orf75	54859	broad.mit.edu	37	chr3	47539889	47539889	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attctcctcatcctccgcatCtccactgtcgtgcacaagga	6	16	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:47539889C>G	uc003crk.2	-	6	678	c.559G>C	c.(559-561)GAT>CAT	p.D187H	C3orf75_uc003crj.2_Missense_Mutation_p.D114H|C3orf75_uc011bba.1_Missense_Mutation_p.D138H|C3orf75_uc003crl.1_Missense_Mutation_p.D187H	NM_001031703	NP_001026873	Q0PNE2	CC075_HUMAN	transmembrane protein 103	187											0						TCCTCCGCATCTCCACTGTCG	0.562													0	0	0	1	0	28	25										G	47539889	C	G	47539889	3	3	100	1	0	0	0	0	1	0	0	0	2245	913	32	1	249	1	C3orf75	3	47539889	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	441489	47539889	150482541	198	30792										
CELSR3	1951	broad.mit.edu	37	chr3	48678958	48678958	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggtcattgccatccacatCtgtggagccaggtcaggtta	12	10	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:48678958C>T	uc003cul.2	-	33	9106	c.8825_splice	c.e33-1	p.D2942_splice	CELSR3_uc003cuf.1_Splice_Site_p.D3040_splice|CELSR3_uc010hkf.2_Splice_Site_p.D232_splice|CELSR3_uc010hkg.2_Splice_Site_p.D925_splice	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3						homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCATCCACATCTGTGGAGCCA	0.597													0	0	0	1	0	23	17										T	48678958	C	T	48678958	5	4	100	1	0	0	0	0	0	0	1	0	3223	927	32	1	1126	1	CELSR3	3	48678958	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1139069	48678958	149343472	199	30793										
CELSR3	1951	broad.mit.edu	37	chr3	48699135	48699135	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcgcgacgaaagcgtgcccgGttcgccgaggttactttcct	13	13	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:48699135G>C	uc003cul.2	-	1	1214	c.933C>G	c.(931-933)AAC>AAG	p.N311K	CELSR3_uc003cuf.1_Missense_Mutation_p.N381K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	311	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGCGTGCCCGGTTCGCCGAGG	0.706													0	0	0	1	0	15	28										C	48699135	G	C	48699135	3	2	100	1	0	0	0	0	1	0	0	0	3223	1252	44	4	9145	4	CELSR3	3	48699135	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	20177	48699135	149323295	200	30794										
NCKIPSD	51517	broad.mit.edu	37	chr3	48716150	48716150	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtggctgtggctcatgtttGaagatgcgcacagggtcatc	15	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:48716150G>C	uc003cun.2	-	12	1906	c.1812C>G	c.(1810-1812)TTC>TTG	p.F604L	NCKIPSD_uc003cum.2_Missense_Mutation_p.F597L	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	604					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTCATGTTTGAAGATGCGCA	0.587													0	0	0	1	0	16	40										C	48716150	G	C	48716150	3	2	100	1	0	0	0	0	1	0	0	0	10225	1281	45	1	364	1	NCKIPSD	3	48716150	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	17015	48716150	149306280	201	30795										
USP19	10869	broad.mit.edu	37	chr3	49153551	49153551	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaaggcagatgtcgatgcgaGaagccgtgaaacagaaggtg	16	6	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:49153551G>C	uc003cwd.1	-	9	1258	c.1097C>G	c.(1096-1098)TCT>TGT	p.S366C	USP19_uc003cwa.2_Missense_Mutation_p.S172C|USP19_uc003cvz.3_Missense_Mutation_p.S467C|USP19_uc011bcg.1_Missense_Mutation_p.S457C|USP19_uc003cwb.2_Missense_Mutation_p.S452C|USP19_uc003cwc.1_Missense_Mutation_p.S122C|USP19_uc011bch.1_Missense_Mutation_p.S467C|USP19_uc011bci.1_Missense_Mutation_p.S452C	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	366	CS 2.|Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTCGATGCGAGAAGCCGTGAA	0.572													0	0	0	1	0	3	16										C	49153551	G	C	49153551	3	2	100	1	0	0	0	0	1	0	0	0	17047	942	33	1	2931	1	USP19	3	49153551	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	437401	49153551	148868879	202	30796										
CCDC36	339834	broad.mit.edu	37	chr3	49293674	49293674	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtgagcagctaggccagctGaatgtgcccagtgtcctagc	13	11	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:49293674G>A	uc003cwk.2	+	10	1131	c.744G>A	c.(742-744)CTG>CTA	p.L248L	CCDC36_uc011bck.1_Silent_p.L248L	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	248										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TAGGCCAGCTGAATGTGCCCA	0.507													0	0	0	1	0	37	23										A	49293674	G	A	49293674	2	1	100	1	0	0	0	0	0	0	0	1	2808	1277	45	1		1	CCDC36	3	49293674	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	140123	49293674	148728756	203	30797										
DOCK3	1795	broad.mit.edu	37	chr3	51418783	51418783	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cactcagccccagggtgcgtCatccctcaggaccccatgga	10	17	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:51418783C>T	uc011bds.1	+	53	5909	c.5886C>T	c.(5884-5886)GTC>GTT	p.V1962V		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1962						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGGGTGCGTCATCCCTCAGG	0.682													0	0	0	1	0	13	29										T	51418783	C	T	51418783	2	4	100	1	0	0	0	0	0	0	0	1	4688	813	29	1		1	DOCK3	3	51418783	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2125109	51418783	146603647	204	30798										
NEK4	6787	broad.mit.edu	37	chr3	52800388	52800388	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaggatgtgtttttcatgtaAatactgaggaaagaaacaag	10	3	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:52800388A>C	uc003dfq.3	-	3	553	c.364T>G	c.(364-366)TTA>GTA	p.L122V	NEK4_uc011bej.1_Missense_Mutation_p.L33V|NEK4_uc003dfr.2_Missense_Mutation_p.L122V	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	122	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TTTTCATGTAAATACTGAGGA	0.333													0	0	0	1	0	24	15										C	52800388	A	C	52800388	3	2	100	1	0	0	0	0	1	0	0	0	10326	11	1	5	2217	5	NEK4	3	52800388	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1381605	52800388	145222042	205	30799										
CCDC66	285331	broad.mit.edu	37	chr3	56655611	56655611	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtagtctcctgcctttagctGaaaatcaagaagagagtttt	9	7	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:56655611G>A	uc003dhz.2	+	18	2899	c.2812G>A	c.(2812-2814)GAA>AAA	p.E938K	CCDC66_uc003dhy.2_Missense_Mutation_p.E574K|CCDC66_uc003dhu.2_Missense_Mutation_p.E904K|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dia.2_Missense_Mutation_p.E306K|C3orf63_uc003dib.3_3'UTR|C3orf63_uc003dic.3_3'UTR|C3orf63_uc003die.3_3'UTR|C3orf63_uc003did.3_3'UTR	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	938										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		GCCTTTAGCTGAAAATCAAGA	0.358													0	0	0	1	0	26	50										A	56655611	G	A	56655611	3	1	100	1	0	0	0	0	1	0	0	0	2838	1291	45	1	2882	1	CCDC66	3	56655611	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3855223	56655611	141366819	206	30800										
FAM116A	201627	broad.mit.edu	37	chr3	57631450	57631450	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaatagtgaaataaggtcgGaaatcactgaagtactttaa	9	4	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:57631450G>C	uc003dja.2	-	11	1046	c.975C>G	c.(973-975)TTC>TTG	p.F325L		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	325										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		AATAAGGTCGGAAATCACTGA	0.343													0	0	0	1	0	10	29										C	57631450	G	C	57631450	3	2	100	1	0	0	0	0	1	0	0	0	5407	1165	41	1	891	1	FAM116A	3	57631450	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	975839	57631450	140390980	207	30801										
PXK	54899	broad.mit.edu	37	chr3	58395832	58395832	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	taaagaagtcaaaacgatctGctcttgaaaatagtgaagag	9	5	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:58395832G>C	uc003djz.1	+	16	1510	c.1411G>C	c.(1411-1413)GCT>CCT	p.A471P	PXK_uc003djx.1_Missense_Mutation_p.A471P|PXK_uc003djy.1_Missense_Mutation_p.A454P|PXK_uc003dka.1_Missense_Mutation_p.A471P|PXK_uc003dkb.1_Missense_Mutation_p.A388P|PXK_uc003dkc.1_Missense_Mutation_p.A454P|PXK_uc011bfe.1_Missense_Mutation_p.A438P|PXK_uc010hnj.1_Missense_Mutation_p.A438P|PXK_uc003dkd.1_Missense_Mutation_p.A334P|PXK_uc010hnk.1_Missense_Mutation_p.A245P	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	471	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AAAACGATCTGCTCTTGAAAA	0.408													0	0	0	1	0	11	15										C	58395832	G	C	58395832	3	2	100	1	0	0	0	0	1	0	0	0	12849	1319	46	4	1473	4	PXK	3	58395832	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	764382	58395832	139626598	208	30802										
OR5H1	26341	broad.mit.edu	37	chr3	97852408	97852408	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctttgttaaatcctatcatCtacagtctgagaaataagca	5	9	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:97852408C>G	uc011bgt.1	+	1	867	c.867C>G	c.(865-867)ATC>ATG	p.I289M		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ATCCTATCATCTACAGTCTGA	0.343													0	0	0	1	0	20	84										G	97852408	C	G	97852408	3	3	100	1	0	0	0	0	1	0	0	0	11159	903	32	1	869	1	OR5H1	3	97852408	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	39456576	97852408	100170022	209	30803										
OR5K1	26339	broad.mit.edu	37	chr3	98189098	98189098	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tatattcttcttactattttCaaaatgaaatccaaagaggg	5	6	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:98189098C>G	uc003dsm.2	+	1	678	c.678C>G	c.(676-678)TTC>TTG	p.F226L		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TTACTATTTTCAAAATGAAAT	0.343													0	0	0	1	0	75	58										G	98189098	C	G	98189098	3	3	100	1	0	0	0	0	1	0	0	0	11166	825	29	1	680	1	OR5K1	3	98189098	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	336690	98189098	99833332	210	30804										
HHLA2	11148	broad.mit.edu	37	chr3	108074154	108074154	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccactgaatattacaggatCaaattcatcttatgaatgta	5	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:108074154C>G	uc003dwy.3	+	5	778	c.611C>G	c.(610-612)TCA>TGA	p.S204*	HHLA2_uc011bhl.1_Nonsense_Mutation_p.S140*|HHLA2_uc010hpu.2_Nonsense_Mutation_p.S204*|HHLA2_uc003dwz.2_Nonsense_Mutation_p.S204*	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	204	Ig-like C1-type.					integral to membrane				ovary(1)	1						ATTACAGGATCAAATTCATCT	0.403													0	0	0	1	0	52	32										G	108074154	C	G	108074154	4	3	100	1	0	0	0	0	0	1	0	0	7095	838	29	1	621	1	HHLA2	3	108074154	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9885056	108074154	89948276	211	30805										
TRAT1	50852	broad.mit.edu	37	chr3	108572606	108572606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcaatagatgccagcgtttCtaagaccaccttagtagaca	8	10	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:108572606C>G	uc003dxi.1	+	6	587	c.443C>G	c.(442-444)TCT>TGT	p.S148C	TRAT1_uc010hpx.1_Missense_Mutation_p.S111C	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	148	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						GCCAGCGTTTCTAAGACCACC	0.458													0	0	0	1	0	39	74										G	108572606	C	G	108572606	3	3	100	1	0	0	0	0	1	0	0	0	16463	913	32	1	465	1	TRAT1	3	108572606	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	498452	108572606	89449824	212	30806										
ATP6V1A	523	broad.mit.edu	37	chr3	113500007	113500007	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agggtgacatggctactattCaggtgtatgaagaaacttgt	12	5	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:113500007C>G	uc003eao.2	+	3	259	c.193C>G	c.(193-195)CAG>GAG	p.Q65E	ATP6V1A_uc011bik.1_Missense_Mutation_p.Q32E	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	65					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						GGCTACTATTCAGGTGTATGA	0.378													0	0	0	1	0	36	107										G	113500007	C	G	113500007	3	3	100	1	0	0	0	0	1	0	0	0	1177	827	29	1	199	1	ATP6V1A	3	113500007	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4927401	113500007	84522423	213	30807										
KPNA1	3836	broad.mit.edu	37	chr3	122160940	122160940	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccacagctcgcaaagcaggaGaaaccactttataatcatta	6	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:122160940G>C	uc003efd.1	-	10	977	c.941C>G	c.(940-942)TCT>TGT	p.S314C	KPNA1_uc003efb.1_Missense_Mutation_p.S113C|KPNA1_uc003efc.1_Missense_Mutation_p.S113C|KPNA1_uc011bjr.1_Missense_Mutation_p.S113C|KPNA1_uc010hrh.2_Missense_Mutation_p.S113C|KPNA1_uc003efe.2_Missense_Mutation_p.S314C	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	314	Binding to RAG1.|ARM 6.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		CAAAGCAGGAGAAACCACTTT	0.338													0	0	0	1	0	25	150										C	122160940	G	C	122160940	3	2	100	1	0	0	0	0	1	0	0	0	8429	942	33	1	695	1	KPNA1	3	122160940	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8660933	122160940	75861490	214	30808										
ADCY5	111	broad.mit.edu	37	chr3	123166643	123166643	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aacatgaccaggcacacgagCaccagcacggccatgagcat	10	14	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:123166643C>T	uc003egh.1	-	1	750	c.750G>A	c.(748-750)GTG>GTA	p.V250V		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	250	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GGCACACGAGCACCAGCACGG	0.662													0	0	0	1	0	8	30										T	123166643	C	T	123166643	2	4	100	1	0	0	0	0	0	0	0	1	297	697	25	2		2	ADCY5	3	123166643	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1005703	123166643	74855787	215	30809										
HEG1	57493	broad.mit.edu	37	chr3	124748209	124748209	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcagcatggctcttcccaGaggtctgaaccatcacgccc	9	15	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:124748209G>A	uc003ehs.3	-	2	508	c.440C>T	c.(439-441)TCT>TTT	p.S147F	HEG1_uc011bke.1_Missense_Mutation_p.S147F	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	147	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GCTCTTCCCAGAGGTCTGAAC	0.483													0	0	0	1	0	20	45										A	124748209	G	A	124748209	3	1	100	1	0	0	0	0	1	0	0	0	7044	942	33	1	3769	1	HEG1	3	124748209	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1581566	124748209	73274221	216	30810										
H1FOO	132243	broad.mit.edu	37	chr3	129269986	129269986	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttccccgaccaaaaagaagGtggtggccaaggccaaggcc	12	13	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:129269986G>C	uc003emu.2	+	5	849	c.844G>C	c.(844-846)GTG>CTG	p.V282L	H1FOO_uc003emv.2_Missense_Mutation_p.V143L	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	282					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						CAAAAAGAAGGTGGTGGCCAA	0.408													0	0	0	1	0	15	53										C	129269986	G	C	129269986	3	2	100	1	0	0	0	0	1	0	0	0	6922	1261	44	4	862	4	H1FOO	3	129269986	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4521777	129269986	68752444	217	30811										
NUDT16	131870	broad.mit.edu	37	chr3	131101103	131101103	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgccaagcgtctgacgctcGaggagctgttggctgtggag	16	9	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:131101103G>C	uc003eof.2	+	2	294	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	uc003eoc.1_5'Flank|NUDT16_uc011bln.1_Missense_Mutation_p.E72Q|NUDT16_uc003eog.1_Missense_Mutation_p.E85Q	NM_152395	NP_689608	Q96DE0	NUD16_HUMAN	nudix-type motif 16	118	Nudix hydrolase.					nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding				0						TCTGACGCTCGAGGAGCTGTT	0.657													0	0	0	1	0	13	38										C	131101103	G	C	131101103	3	2	100	1	0	0	0	0	1	0	0	0	10732	1059	37	1	358	1	NUDT16	3	131101103	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1831117	131101103	66921327	218	30812										
PCOLCE2	26577	broad.mit.edu	37	chr3	142606552	142606552	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctatttggagggtacactcCaggaaaaccttcactgccaa	9	11	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:142606552C>T	uc003evd.2	-	2	347	c.151G>A	c.(151-153)GGA>AGA	p.G51R		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	51	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GGGTACACTCCAGGAAAACCT	0.398													0	0	0	1	0	19	30										T	142606552	C	T	142606552	3	4	100	1	0	0	0	0	1	0	0	0	11595	603	21	2	1128	2	PCOLCE2	3	142606552	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11505449	142606552	55415878	219	30813										
MLF1	4291	broad.mit.edu	37	chr3	158314723	158314723	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaaactatatgcagaaattaGaaagaaacttcgtaagtact	7	5	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:158314723G>C	uc003fcb.2	+	3	405	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	MLF1_uc003fbz.2_Missense_Mutation_p.E65Q|MLF1_uc003fca.2_Missense_Mutation_p.E65Q|MLF1_uc003fbx.2_Missense_Mutation_p.E80Q|MLF1_uc003fcc.2_Missense_Mutation_p.E121Q|MLF1_uc003fby.2_Missense_Mutation_p.E16Q|MLF1_uc010hvx.2_Missense_Mutation_p.E65Q	NM_022443	NP_071888	P58340	MLF1_HUMAN	myeloid leukemia factor 1 isoform 1	90	Interaction with COPS3.				cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding				0		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)			GCAGAAATTAGAAAGAAACTT	0.264			T	NPM1	AML								0	0	0	1	0	20	6										C	158314723	G	C	158314723	3	2	100	1	0	0	0	0	1	0	0	0	9614	943	33	1	278	1	MLF1	3	158314723	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	15708171	158314723	39707707	220	30814										
SMC4	10051	broad.mit.edu	37	chr3	160150149	160150149	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gttttagacaggcatatgaaGatcttcggaaacaaaggctt	10	6	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:160150149G>C	uc003fdh.2	+	22	3489	c.3376G>C	c.(3376-3378)GAT>CAT	p.D1126H	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.D1101H|SMC4_uc003fdj.2_Missense_Mutation_p.D1126H|SMC4_uc010hwd.2_Missense_Mutation_p.D1068H|SMC4_uc003fdl.2_Missense_Mutation_p.D829H	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1126	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGCATATGAAGATCTTCGGAA	0.338													0	0	0	1	0	16	65										C	160150149	G	C	160150149	3	2	100	1	0	0	0	0	1	0	0	0	14785	942	33	1	3458	1	SMC4	3	160150149	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1835426	160150149	37872281	221	30815										
PPM1L	151742	broad.mit.edu	37	chr3	160786817	160786817	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcagttcgattcatcaagGagcgcttggatgaacctcac	10	10	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:160786817G>A	uc003fdr.2	+	4	1056	c.955G>A	c.(955-957)GAG>AAG	p.E319K	PPM1L_uc003fds.2_Missense_Mutation_p.E140K|PPM1L_uc003fdt.2_Missense_Mutation_p.E192K|PPM1L_uc010hwf.2_RNA	NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	319	Cytoplasmic (Potential).|PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			ATTCATCAAGGAGCGCTTGGA	0.468													0	0	0	1	0	58	45										A	160786817	G	A	160786817	3	1	100	1	0	0	0	0	1	0	0	0	12344	1175	41	1	969	1	PPM1L	3	160786817	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	636668	160786817	37235613	222	30816										
PRKCI	5584	broad.mit.edu	37	chr3	170020896	170020896	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tatcaatcctcttttgatgtCtgcagaagaatgtgtctgat	8	7	4	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:170020896C>G	uc003fgs.2	+	18	2010	c.1772C>G	c.(1771-1773)TCT>TGT	p.S591C	PRKCI_uc003fgt.2_Missense_Mutation_p.S146C	NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	591	AGC-kinase C-terminal.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CTTTTGATGTCTGCAGAAGAA	0.333													0	0	0	1	0	8	40										G	170020896	C	G	170020896	3	3	100	1	0	0	0	0	1	0	0	0	12514	913	32	1	1842	1	PRKCI	3	170020896	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9234079	170020896	28001534	223	30817										
SKIL	6498	broad.mit.edu	37	chr3	170108880	170108880	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaactcactgaagaacagcaGaatttacagaaagagcttga	9	7	1	6			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:170108880G>C	uc003fgu.2	+	6	2440	c.1728G>C	c.(1726-1728)CAG>CAC	p.Q576H	SKIL_uc011bps.1_Missense_Mutation_p.Q556H|SKIL_uc003fgv.2_Missense_Mutation_p.Q530H|SKIL_uc003fgw.2_Missense_Mutation_p.Q576H	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	576	Potential.				cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			AAGAACAGCAGAATTTACAGA	0.313													0	0	0	1	0	31	10										C	170108880	G	C	170108880	3	2	100	1	0	0	0	0	1	0	0	0	14358	933	33	1	1746	1	SKIL	3	170108880	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	87984	170108880	27913550	224	30818										
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	25	84										A	178936082	G	A	178936082	3	1	100	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1658	1	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8827202	178936082	19086348	225	30819										
MCF2L2	23101	broad.mit.edu	37	chr3	183097188	183097188	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgatgggggcgccatcctCccctcggcctcctgcaacaa	11	16	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:183097188C>G	uc003fli.1	-	3	262	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	MCF2L2_uc003flj.1_Missense_Mutation_p.E58Q|MCF2L2_uc003flp.1_Missense_Mutation_p.E93Q	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	58	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GCGCCATCCTCCCCTCGGCCT	0.512													0	0	0	1	0	23	9										G	183097188	C	G	183097188	3	3	100	1	0	0	0	0	1	0	0	0	9380	864	30	1	3284	1	MCF2L2	3	183097188	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4161106	183097188	14925242	226	30820										
CHRD	8646	broad.mit.edu	37	chr3	184107170	184107170	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccagcagccccagagaccaGaactgatccagagctggaga	11	13	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:184107170G>A	uc003fov.2	+	23	3074	c.2828G>A	c.(2827-2829)AGA>AAA	p.R943K	CHRD_uc003fow.2_Missense_Mutation_p.R573K|CHRD_uc003fox.2_Missense_Mutation_p.R942K|CHRD_uc003foy.2_Missense_Mutation_p.R573K|CHRD_uc010hyc.2_Missense_Mutation_p.R533K|CHRD_uc011brr.1_Missense_Mutation_p.R485K	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	943					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCAGAGACCAGAACTGATCCA	0.512													0	0	0	1	0	6	13										A	184107170	G	A	184107170	3	1	100	1	0	0	0	0	1	0	0	0	3372	942	33	1	2918	1	CHRD	3	184107170	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1009982	184107170	13915260	227	30821										
AHSG	197	broad.mit.edu	37	chr3	186334313	186334313	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acgcaaaatgtgattccagtCcaggtacagatgactattct	8	9	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:186334313C>G	uc003fqk.3	+	3	487	c.406C>G	c.(406-408)CCA>GCA	p.P136A	AHSG_uc003fqj.2_Missense_Mutation_p.P136A|AHSG_uc003fql.3_Missense_Mutation_p.P136A|AHSG_uc003fqm.3_Missense_Mutation_p.P135A|AHSG_uc010hyp.2_Missense_Mutation_p.P99A	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	136					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TGATTCCAGTCCAGGTACAGA	0.413													0	0	0	1	0	4	20										G	186334313	C	G	186334313	3	3	100	1	0	0	0	0	1	0	0	0	420	855	30	1	416	1	AHSG	3	186334313	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2227143	186334313	11688117	228	30822										
CLDN16	10686	broad.mit.edu	37	chr3	190120206	190120206	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgcacctgtgatgagtacgaTtccatacttgcggagcatcc	10	12	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:190120206T>C	uc003fsi.2	+	2	473	c.405T>C	c.(403-405)GAT>GAC	p.D135D	CLDN16_uc010hze.2_Intron	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	135	Extracellular (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		ATGAGTACGATTCCATACTTG	0.488													0	0	0	1	0	28	89										C	190120206	T	C	190120206	2	2	100	1	0	0	0	0	0	0	0	1	3477	1490	52	5		5	CLDN16	3	190120206	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	3785893	190120206	7902224	229	30823										
LSG1	55341	broad.mit.edu	37	chr3	194371614	194371614	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagcagaaaggatattagtGatacaggaggaacatgatct	11	4	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:194371614G>C	uc003fui.2	-	10	1730	c.1415C>G	c.(1414-1416)TCA>TGA	p.S472*		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	472					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		GGATATTAGTGATACAGGAGG	0.418													0	0	0	1	0	25	49										C	194371614	G	C	194371614	4	2	100	1	0	0	0	0	0	1	0	0	9049	1294	45	1	581	1	LSG1	3	194371614	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4251408	194371614	3650816	230	30824										
PPP1R2	5504	broad.mit.edu	37	chr3	195251628	195251628	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtacttacttcctggctaaGatgtctggcgccatggcttc	10	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:195251628G>A	uc003fup.2	-	3	673	c.297C>T	c.(295-297)ATC>ATT	p.I99I		NM_006241	NP_006232	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory subunit 2	99					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			urinary_tract(1)	1	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		TCCTGGCTAAGATGTCTGGCG	0.468													0	0	0	1	0	21	33										A	195251628	G	A	195251628	2	1	100	1	0	0	0	0	0	0	0	1	12370	932	33	1		1	PPP1R2	3	195251628	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	880014	195251628	2770802	231	30825										
CRMP1	1400	broad.mit.edu	37	chr4	5851128	5851128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgccactcacctgagctatCaaatctccattttctgcatg	5	13	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:5851128C>G	uc003gip.2	-	7	713	c.612G>C	c.(610-612)TTG>TTC	p.L204F	CRMP1_uc003gin.1_Missense_Mutation_p.L116F|CRMP1_uc003giq.2_Missense_Mutation_p.L204F|CRMP1_uc003gir.2_Missense_Mutation_p.L199F|CRMP1_uc003gis.2_Missense_Mutation_p.L318F	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	204					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CCTGAGCTATCAAATCTCCAT	0.458													0	0	0	1	0	15	59										G	5851128	C	G	5851128	3	3	100	1	0	0	0	0	1	0	0	0	3890	825	29	1	1142	1	CRMP1	4	5851128	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		5851128	185303148	232	30826										
BOD1L	259282	broad.mit.edu	37	chr4	13604756	13604756	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcttcagcagctgtgtttttCaaattcttctgtaccctatc	5	11	5	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:13604756C>G	uc003gmz.1	-	10	3885	c.3768G>C	c.(3766-3768)TTG>TTC	p.L1256F	BOD1L_uc010idr.1_Missense_Mutation_p.L593F	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1256							DNA binding			ovary(5)|breast(1)	6						CTGTGTTTTTCAAATTCTTCT	0.393													0	0	0	1	0	6	58										G	13604756	C	G	13604756	3	3	100	1	0	0	0	0	1	0	0	0	1483	825	29	1	5455	1	BOD1L	4	13604756	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	7753628	13604756	177549520	233	30827										
SEL1L3	23231	broad.mit.edu	37	chr4	25760599	25760599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggagaatggagatgttattaGaatggagagttgagtcaatt	14	1	1	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:25760599G>C	uc003gru.3	-	21	3199	c.3047C>G	c.(3046-3048)TCT>TGT	p.S1016C	SEL1L3_uc003grt.2_Missense_Mutation_p.S64C|SEL1L3_uc003grv.2_Missense_Mutation_p.S423C	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	1016						integral to membrane	binding				0						GATGTTATTAGAATGGAGAGT	0.428													0	0	0	1	0	41	48										C	25760599	G	C	25760599	3	2	100	1	0	0	0	0	1	0	0	0	14012	942	33	1	367	1	SEL1L3	4	25760599	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	12155843	25760599	165393677	234	30828										
RBPJ	3516	broad.mit.edu	37	chr4	26417162	26417162	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaagaaaaaaaaagaacaaaTggaacgcgatggttgttctg	11	4	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:26417162T>C	uc003grx.1	+	5	496	c.260T>C	c.(259-261)ATG>ACG	p.M87T	RBPJ_uc003gry.1_Missense_Mutation_p.M72T|RBPJ_uc003grz.1_Missense_Mutation_p.M87T|RBPJ_uc011bxt.1_Missense_Mutation_p.M87T|RBPJ_uc003gsa.1_Missense_Mutation_p.M73T|RBPJ_uc003gsb.1_Missense_Mutation_p.M74T|RBPJ_uc003gsc.1_Missense_Mutation_p.M73T	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	87					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				AAAGAACAAATGGAACGCGAT	0.388													0	0	0	1	0	37	94										C	26417162	T	C	26417162	3	2	100	1	0	0	0	0	1	0	0	0	13161	1464	51	5	337	5	RBPJ	4	26417162	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	656563	26417162	164737114	235	30829										
PCDH7	5099	broad.mit.edu	37	chr4	30723251	30723251	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggtgactttcagcctggaGtccggttccgagtacctgaa	13	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:30723251G>T	uc003gsk.1	+	1	1215	c.207G>T	c.(205-207)GAG>GAT	p.E69D	PCDH7_uc011bxw.1_Missense_Mutation_p.E69D|PCDH7_uc011bxx.1_Missense_Mutation_p.E69D	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	69	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TCAGCCTGGAGTCCGGTTCCG	0.647													1	0	3.59834e-05	1	3.70396e-05	6	34										T	30723251	G	T	30723251	3	4	100	1	0	0	0	0	1	0	0	0	11516	1020	36	4	209	4	PCDH7	4	30723251	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4306089	30723251	160431025	236	30830										
PCDH7	5099	broad.mit.edu	37	chr4	30724469	30724469	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagctcaagccagccagcgaCaccgagggcgaccagaacaa	11	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:30724469C>T	uc003gsk.1	+	1	2433	c.1425C>T	c.(1423-1425)GAC>GAT	p.D475D	PCDH7_uc011bxw.1_Silent_p.D428D|PCDH7_uc011bxx.1_Silent_p.D475D	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	475	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CAGCCAGCGACACCGAGGGCG	0.627													0	0	0	1	0	8	31										T	30724469	C	T	30724469	2	4	100	1	0	0	0	0	0	0	0	1	11516	477	17	2		2	PCDH7	4	30724469	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1218	30724469	160429807	237	30831										
WDR19	57728	broad.mit.edu	37	chr4	39280196	39280196	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcacatgtcctatgtgttcaGaaagattaaacgctgctcag	9	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:39280196G>C	uc003gtv.2	+	36	4109	c.3955G>C	c.(3955-3957)GAA>CAA	p.E1319Q	WDR19_uc011byi.1_Missense_Mutation_p.E1159Q	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1319					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TATGTGTTCAGAAAGATTAAA	0.443													0	0	0	1	0	23	37										C	39280196	G	C	39280196	3	2	100	1	0	0	0	0	1	0	0	0	17276	943	33	1	4097	1	WDR19	4	39280196	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8555727	39280196	151874080	238	30832										
TXK	7294	broad.mit.edu	37	chr4	48078437	48078437	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accttgtcattccaaagtctGaaatttttactatgcatgtt	5	8	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:48078437G>C	uc003gxx.3	-	12	1306	c.1220C>G	c.(1219-1221)TCA>TGA	p.S407*	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Nonsense_Mutation_p.S94*	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	407	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCCAAAGTCTGAAATTTTTAC	0.308													0	0	0	1	0	14	31										C	48078437	G	C	48078437	4	2	100	1	0	0	0	0	0	1	0	0	16783	1294	45	1	379	1	TXK	4	48078437	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8798241	48078437	143075839	239	30833										
TXK	7294	broad.mit.edu	37	chr4	48078458	48078458	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaatttttactatgcatgttGaactgaccaaacaattcctt	4	8	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:48078458G>A	uc003gxx.3	-	12	1285	c.1199C>T	c.(1198-1200)TCA>TTA	p.S400L	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Missense_Mutation_p.S87L	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	400	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TATGCATGTTGAACTGACCAA	0.323													0	0	0	1	0	16	38										A	48078458	G	A	48078458	3	1	100	1	0	0	0	0	1	0	0	0	16783	1294	45	1	400	1	TXK	4	48078458	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	21	48078458	143075818	240	30834										
SLAIN2	57606	broad.mit.edu	37	chr4	48371957	48371957	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagttttggattacccaagtCctgatgttgagtgtgctaaa	10	6	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:48371957C>T	uc003gya.3	+	2	625	c.481C>T	c.(481-483)CCT>TCT	p.P161S		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	161						centrosome					0						TTACCCAAGTCCTGATGTTGA	0.358													0	0	0	1	0	8	45										T	48371957	C	T	48371957	3	4	100	1	0	0	0	0	1	0	0	0	14366	855	30	1	487	1	SLAIN2	4	48371957	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	293499	48371957	142782319	241	30835										
PPAT	5471	broad.mit.edu	37	chr4	57272738	57272738	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccatgaagtgtttcaacaaCgaagggctgacaattttcta	8	9	2	2	rs141469911		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:57272738C>T	uc003hbr.2	-	3	527	c.325G>A	c.(325-327)GTT>ATT	p.V109I		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	109	Glutamine amidotransferase type-2.				glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	GTTTCAACAACGAAGGGCTGA	0.378													0	0	0	1	0	22	50										T	57272738	C	T	57272738	3	4	100	1	0	0	0	0	1	0	0	0	12302	536	19	2	1264	2	PPAT	4	57272738	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	8900781	57272738	133881538	242	30836										
UBA6	55236	broad.mit.edu	37	chr4	68530981	68530981	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggttccagttctgtggtgtCaccaatactaaaagaaaatg	9	7	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:68530981C>T	uc003hdg.3	-	10	875	c.823G>A	c.(823-825)GAC>AAC	p.D275N	UBA6_uc003hdi.2_Missense_Mutation_p.D275N|UBA6_uc003hdj.2_Missense_Mutation_p.D275N	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	275					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TCTGTGGTGTCACCAATACTA	0.299													0	0	0	1	0	14	44										T	68530981	C	T	68530981	3	4	100	1	0	0	0	0	1	0	0	0	16829	826	29	1	2431	1	UBA6	4	68530981	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11258243	68530981	122623295	243	30837										
YTHDC1	91746	broad.mit.edu	37	chr4	69202901	69202901	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcttcttcttcctcctcctCctcctcctcttcctcctcct	0	22	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:69202901C>G	uc003hdx.2	-	4	1080	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	YTHDC1_uc003hdy.2_Missense_Mutation_p.E243Q	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	243	Glu-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						tcctcctcctcctcctcctct	0.184													0	0	0	1	0	7	31										G	69202901	C	G	69202901	3	3	100	1	0	0	0	0	1	0	0	0	17493	864	30	1	1512	1	YTHDC1	4	69202901	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	671920	69202901	121951375	244	30838										
MOBKL1A	92597	broad.mit.edu	37	chr4	71824646	71824646	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agaacattccagagggttctCaccagtatgagctcttaaaa	8	9	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:71824646C>T	uc003hfw.2	+	2	260	c.70C>T	c.(70-72)CAC>TAC	p.H24Y	MOBKL1A_uc003hfv.1_Missense_Mutation_p.H24Y|MOBKL1A_uc011cba.1_Missense_Mutation_p.H29Y	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	24					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			AGAGGGTTCTCACCAGTATGA	0.413													0	0	0	1	0	59	24										T	71824646	C	T	71824646	3	4	100	1	0	0	0	0	1	0	0	0	9682	826	29	1	76	1	MOBKL1A	4	71824646	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2621745	71824646	119329630	245	30839										
MOBKL1A	92597	broad.mit.edu	37	chr4	71824735	71824735	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcctgaaggggaagatctCaatgaatgggttgcagttaa	12	6	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:71824735C>T	uc003hfw.2	+	2	349	c.159C>T	c.(157-159)CTC>CTT	p.L53L	MOBKL1A_uc003hfv.1_Silent_p.L53L|MOBKL1A_uc011cba.1_Silent_p.L58L	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	53					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			GGGAAGATCTCAATGAATGGG	0.468													0	0	0	1	0	29	22										T	71824735	C	T	71824735	2	4	100	1	0	0	0	0	0	0	0	1	9682	813	29	1		1	MOBKL1A	4	71824735	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	89	71824735	119329541	246	30840										
SEPT11	55752	broad.mit.edu	37	chr4	77952017	77952017	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acaagaagaaggagcttgagGaggaggtgaacaacttccag	14	6	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:77952017G>T	uc003hkj.2	+	9	1330	c.1168G>T	c.(1168-1170)GAG>TAG	p.E390*	SEPT11_uc010ijh.1_Nonsense_Mutation_p.E382*|SEPT11_uc011cca.1_Nonsense_Mutation_p.E400*	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	390	Potential.				cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						GGAGCTTGAGGAGGAGGTGAA	0.468													1	0	7.48243e-07	1	7.82884e-07	10	37										T	77952017	G	T	77952017	4	4	100	1	0	0	0	0	0	1	0	0	14061	1175	41	3	1202	3	SEPT11	4	77952017	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	6127282	77952017	113202259	247	30841										
SCD5	79966	broad.mit.edu	37	chr4	83552481	83552481	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgggatggctgttccaagttCaagcactgctgtctccagtc	11	11	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:83552481C>G	uc003hna.2	-	5	1312	c.992G>C	c.(991-993)TGA>TCA	p.*331S		NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	331					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				GTTCCAAGTTCAAGCACTGCT	0.562													0	0	0	1	0	5	17										G	83552481	C	G	83552481	4	3	100	1	0	0	0	0	0	0	0	0	13887	837	29	1	4	1	SCD5	4	83552481	Nonstop_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5600464	83552481	107601795	248	30842										
COPS4	51138	broad.mit.edu	37	chr4	83984258	83984258	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gttctcggatgctagctactCtttttaaggatgaaaggtgc	11	7	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:83984258C>G	uc003hoa.2	+	7	884	c.745C>G	c.(745-747)CTT>GTT	p.L249V	COPS4_uc003hob.2_Missense_Mutation_p.L249V|COPS4_uc010ijw.2_Missense_Mutation_p.L249V|COPS4_uc010ijx.2_Missense_Mutation_p.L249V	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	249	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				GCTAGCTACTCTTTTTAAGGA	0.378													0	0	0	1	0	20	55										G	83984258	C	G	83984258	3	3	100	1	0	0	0	0	1	0	0	0	3735	913	32	1	771	1	COPS4	4	83984258	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	431777	83984258	107170018	249	30843										
PTPN13	5783	broad.mit.edu	37	chr4	87622564	87622564	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attctggacgtgaagattctGaaaatacattctccccttac	6	10	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:87622564G>C	uc003hpz.2	+	7	1285	c.805G>C	c.(805-807)GAA>CAA	p.E269Q	PTPN13_uc003hpy.2_Missense_Mutation_p.E269Q|PTPN13_uc003hqa.2_Missense_Mutation_p.E269Q|PTPN13_uc003hqb.2_Missense_Mutation_p.E269Q	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	269						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TGAAGATTCTGAAAATACATT	0.383													0	0	0	1	0	9	23										C	87622564	G	C	87622564	3	2	100	1	0	0	0	0	1	0	0	0	12782	1291	45	1	827	1	PTPN13	4	87622564	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3638306	87622564	103531712	250	30844										
SLC10A6	345274	broad.mit.edu	37	chr4	87749251	87749251	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggtgatgtctgaattccaaGatcctttcgccaggaccaca	10	11	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:87749251G>C	uc003hqd.2	-	4	804	c.656C>G	c.(655-657)TCT>TGT	p.S219C		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	219	Extracellular (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		TGAATTCCAAGATCCTTTCGC	0.478													0	0	0	1	0	7	40										C	87749251	G	C	87749251	3	2	100	1	0	0	0	0	1	0	0	0	14378	942	33	1	489	1	SLC10A6	4	87749251	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	126687	87749251	103405025	251	30845										
HERC6	55008	broad.mit.edu	37	chr4	89363544	89363544	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attctacaatggaaagaatgGaggaagcacttcaagtagcc	10	7	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:89363544G>C	uc011cdi.1	+	23	3184	c.3001G>C	c.(3001-3003)GAG>CAG	p.E1001Q	HERC6_uc011cdj.1_Missense_Mutation_p.E965Q|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	1001	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GGAAAGAATGGAGGAAGCACT	0.428													0	0	0	1	0	4	18										C	89363544	G	C	89363544	3	2	100	1	0	0	0	0	1	0	0	0	7062	1175	41	1	2888	1	HERC6	4	89363544	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1614293	89363544	101790732	252	30846										
FAM13A	10144	broad.mit.edu	37	chr4	89912254	89912254	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtagtgggtgtctggcagctCttttattaagtctcttaagc	11	7	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:89912254C>G	uc003hse.1	-	4	683	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsh.1_5'UTR|FAM13A_uc003hsi.2_Missense_Mutation_p.E159Q|FAM13A_uc003hsj.2_Missense_Mutation_p.E159Q	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	159	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TCTGGCAGCTCTTTTATTAAG	0.383													0	0	0	1	0	6	20										G	89912254	C	G	89912254	3	3	100	1	0	0	0	0	1	0	0	0	5452	922	32	1	2713	1	FAM13A	4	89912254	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	548710	89912254	101242022	253	30847										
TBCK	93627	broad.mit.edu	37	chr4	107170104	107170104	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatgtccaaacaaccatgctCttcagccagaactattaaag	5	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:107170104C>T	uc010ilv.2	-	8	1059	c.694G>A	c.(694-696)GAG>AAG	p.E232K	TBCK_uc003hyb.2_5'Flank|TBCK_uc003hye.2_Missense_Mutation_p.E193K|TBCK_uc003hyc.2_Missense_Mutation_p.E169K|TBCK_uc003hyd.2_Missense_Mutation_p.E60K|TBCK_uc003hyf.2_Missense_Mutation_p.E232K	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	232	Protein kinase.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CAACCATGCTCTTCAGCCAGA	0.219													0	0	0	1	0	18	15										T	107170104	C	T	107170104	3	4	100	1	0	0	0	0	1	0	0	0	15633	922	32	1	2063	1	TBCK	4	107170104	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	17257850	107170104	83984172	254	30848										
SEC24B	10427	broad.mit.edu	37	chr4	110384480	110384480	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgtggtcattatgctatgtCaactgtttctaatgccgcgt	9	8	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:110384480C>G	uc003hzk.2	+	2	612	c.557C>G	c.(556-558)TCA>TGA	p.S186*	SEC24B_uc003hzl.2_Nonsense_Mutation_p.S186*|SEC24B_uc011cfp.1_Nonsense_Mutation_p.S217*|SEC24B_uc011cfq.1_Nonsense_Mutation_p.S186*|SEC24B_uc011cfr.1_Nonsense_Mutation_p.S186*	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	186					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TATGCTATGTCAACTGTTTCT	0.453													0	0	0	1	0	44	144										G	110384480	C	G	110384480	4	3	100	1	0	0	0	0	0	1	0	0	13995	838	29	1	563	1	SEC24B	4	110384480	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3214376	110384480	80769796	255	30849										
PRDM5	11107	broad.mit.edu	37	chr4	121828712	121828712	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagggtccgaacttttcacCctgagtagcaatgattatat	8	8	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:121828712C>A	uc003idn.2	-	2	344	c.94G>T	c.(94-96)GGT>TGT	p.G32C	PRDM5_uc003ido.2_Missense_Mutation_p.G32C|PRDM5_uc010ine.2_Missense_Mutation_p.G32C|PRDM5_uc010inf.2_Missense_Mutation_p.G32C|PRDM5_uc003idp.1_Missense_Mutation_p.G32C	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	32	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						AACTTTTCACCCTGAGTAGCA	0.358													1	0	5.35267e-07	1	5.62362e-07	20	26										A	121828712	C	A	121828712	3	1	100	1	0	0	0	0	1	0	0	0	12460	637	22	4	1858	4	PRDM5	4	121828712	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11444232	121828712	69325564	256	30850										
KIAA1109	84162	broad.mit.edu	37	chr4	123274148	123274148	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tatttcagattccattaccaGaagatggaatgcaatttgga	8	6	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:123274148G>C	uc003ieh.2	+	79	13984	c.13939G>C	c.(13939-13941)GAA>CAA	p.E4647Q	KIAA1109_uc003iem.2_Missense_Mutation_p.E1003Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4647					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCCATTACCAGAAGATGGAAT	0.413													0	0	0	1	0	20	33										C	123274148	G	C	123274148	3	2	100	1	0	0	0	0	1	0	0	0	8208	943	33	1	14253	1	KIAA1109	4	123274148	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1445436	123274148	67880128	257	30851										
SLC25A31	83447	broad.mit.edu	37	chr4	128665848	128665848	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttcttcagtttttggcgtgGcaatttggcaaatgttattc	9	6	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:128665848G>T	uc003ifl.2	+	2	400	c.254G>T	c.(253-255)GGC>GTC	p.G85V		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	85	Solcar 1.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						TTTTGGCGTGGCAATTTGGCA	0.318													1	0	2.23348e-06	1	2.32731e-06	17	67										T	128665848	G	T	128665848	3	4	100	1	0	0	0	0	1	0	0	0	14495	1203	42	4	260	4	SLC25A31	4	128665848	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5391700	128665848	62488428	258	30852										
RNF150	57484	broad.mit.edu	37	chr4	141832307	141832307	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagaactcactgttagtagTaaagatgacgtctccctcct	8	11	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:141832307T>G	uc003iio.1	-	6	1843	c.1189A>C	c.(1189-1191)ACT>CCT	p.T397P	RNF150_uc010iok.1_Missense_Mutation_p.T355P|RNF150_uc003iip.1_Missense_Mutation_p.T397P	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	397	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					CTGTTAGTAGTAAAGATGACG	0.463													0	0	0	1	0	5	33										G	141832307	T	G	141832307	3	3	100	1	0	0	0	0	1	0	0	0	13451	1638	57	5	135	5	RNF150	4	141832307	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	13166459	141832307	49321969	259	30853										
MORF4	10934	broad.mit.edu	37	chr4	174537200	174537200	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atcgtgaagataattgagtaAtaaagcaaggctcttctcat	8	6	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:174537200A>G	uc011cke.1	-	1	595	c.595T>C	c.(595-597)TTA>CTA	p.L199L		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TAATTGAGTAATAAAGCAAGG	0.428													0	0	0	1	0	22	30										G	174537200	A	G	174537200	2	3	100	1	0	0	0	0	0	0	0	1	9705	98	4	5		5	MORF4	4	174537200	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	32704893	174537200	16617076	260	30854										
CTNND2	1501	broad.mit.edu	37	chr5	11411762	11411762	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atcttcgatatctttttgacCatctgaaatgaaatatttta	4	6	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:11411762C>A	uc003jfa.1	-	5	470	c.325G>T	c.(325-327)GGT>TGT	p.G109C	CTNND2_uc010itt.2_Missense_Mutation_p.G18C|CTNND2_uc011cmy.1_Missense_Mutation_p.G18C|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	109					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCTTTTTGACCATCTGAAATG	0.338													1	0	9.62906e-15	1	1.05753e-14	42	27										A	11411762	C	A	11411762	3	1	100	1	0	0	0	0	1	0	0	0	4020	594	21	4	3424	4	CTNND2	5	11411762	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		11411762	169503498	261	30855										
MYO10	4651	broad.mit.edu	37	chr5	16769282	16769282	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgacacttcccgaacttcctCcttgctgaactgcatcacgt	6	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:16769282C>G	uc003jft.3	-	10	1429	c.961G>C	c.(961-963)GAG>CAG	p.E321Q	MYO10_uc010itx.2_5'Flank	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	321	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CGAACTTCCTCCTTGCTGAAC	0.418													0	0	0	1	0	7	34										G	16769282	C	G	16769282	3	3	100	1	0	0	0	0	1	0	0	0	10062	864	30	1	5343	1	MYO10	5	16769282	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5357520	16769282	164145978	262	30856										
CDH6	1004	broad.mit.edu	37	chr5	31317550	31317550	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caccaattttcgttttccttGgcccctgaagcagccagtgg	9	13	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:31317550G>C	uc003jhe.1	+	10	1907	c.1581G>C	c.(1579-1581)TTG>TTC	p.L527F	CDH6_uc003jhd.1_Missense_Mutation_p.L527F	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	527	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CGTTTTCCTTGGCCCCTGAAG	0.413													0	0	0	1	0	29	114										C	31317550	G	C	31317550	3	2	100	1	0	0	0	0	1	0	0	0	3114	1339	47	4	1615	4	CDH6	5	31317550	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	14548268	31317550	149597710	263	30857										
PDZD2	23037	broad.mit.edu	37	chr5	32074700	32074700	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctcgagagtccaggccacttCtgtcaaagtgactgtcgctg	11	12	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:32074700C>T	uc003jhl.2	+	18	3876	c.3488C>T	c.(3487-3489)TCT>TTT	p.S1163F	PDZD2_uc003jhm.2_Missense_Mutation_p.S1163F|PDZD2_uc011cnx.1_Missense_Mutation_p.S989F	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1163					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CAGGCCACTTCTGTCAAAGTG	0.522													0	0	0	1	0	41	23										T	32074700	C	T	32074700	3	4	100	1	0	0	0	0	1	0	0	0	11701	913	32	1	3554	1	PDZD2	5	32074700	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	757150	32074700	148840560	264	30858										
NIPBL	25836	broad.mit.edu	37	chr5	37016225	37016225	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttcaacagtcaataagcctGaatggccagctgctgaacta	8	10	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:37016225G>A	uc003jkl.3	+	23	5228	c.4729G>A	c.(4729-4731)GAA>AAA	p.E1577K	NIPBL_uc003jkk.3_Missense_Mutation_p.E1577K	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1577					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CAATAAGCCTGAATGGCCAGC	0.368													0	0	0	1	0	57	34										A	37016225	G	A	37016225	3	1	100	1	0	0	0	0	1	0	0	0	10428	1291	45	1	4815	1	NIPBL	5	37016225	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4941525	37016225	143899035	265	30859										
EGFLAM	133584	broad.mit.edu	37	chr5	38407999	38407999	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggcatttcaaattactcttGaatttagggtaagagggatg	11	4	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:38407999G>C	uc003jlc.1	+	9	1564	c.1240G>C	c.(1240-1242)GAA>CAA	p.E414Q	EGFLAM_uc003jlb.1_Missense_Mutation_p.E414Q|EGFLAM_uc003jle.1_Missense_Mutation_p.E180Q|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	414	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AATTACTCTTGAATTTAGGGT	0.413													0	0	0	1	0	13	61										C	38407999	G	C	38407999	3	2	100	1	0	0	0	0	1	0	0	0	4966	1291	45	1	1288	1	EGFLAM	5	38407999	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1391774	38407999	142507261	266	30860										
HCN1	348980	broad.mit.edu	37	chr5	45396805	45396805	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgaatactgctttccccaaGaatcattctgcaacataaga	5	10	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:45396805G>A	uc003jok.2	-	4	1044	c.1019C>T	c.(1018-1020)TCT>TTT	p.S340F		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	340	Extracellular (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTTTCCCCAAGAATCATTCTG	0.428													0	0	0	1	0	19	59										A	45396805	G	A	45396805	3	1	100	1	0	0	0	0	1	0	0	0	6996	942	33	1	1673	1	HCN1	5	45396805	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	6988806	45396805	135518455	267	30861										
DHX29	54505	broad.mit.edu	37	chr5	54581607	54581607	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcttcctgacccaatcaatCagaaattgtttgggagattt	7	8	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:54581607C>G	uc003jpx.2	-	9	1269	c.1149G>C	c.(1147-1149)CTG>CTC	p.L383L	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	383							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				CCCAATCAATCAGAAATTGTT	0.348													0	0	0	1	0	13	14										G	54581607	C	G	54581607	2	3	100	1	0	0	0	0	0	0	0	1	4503	813	29	1		1	DHX29	5	54581607	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9184802	54581607	126333653	268	30862										
GFM2	84340	broad.mit.edu	37	chr5	74035829	74035829	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttacagaaattcatagttaCgctcttcaggtgaaggtaag	9	7	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:74035829C>G	uc003kdh.1	-	12	1368	c.1064G>C	c.(1063-1065)CGT>CCT	p.R355P	GFM2_uc003kdi.1_Missense_Mutation_p.R355P|GFM2_uc010izj.1_Missense_Mutation_p.R387P|GFM2_uc010izk.1_RNA|GFM2_uc003kdj.1_Missense_Mutation_p.R355P|GFM2_uc010izl.1_Missense_Mutation_p.R313P	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	355					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TTCATAGTTACGCTCTTCAGG	0.363													0	0	0	1	0	17	1										G	74035829	C	G	74035829	3	3	100	1	0	0	0	0	1	0	0	0	6342	536	19	4	1347	4	GFM2	5	74035829	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	19454222	74035829	106879431	269	30863										
WDR41	55255	broad.mit.edu	37	chr5	76736794	76736794	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcccagatgatcagctctccGacgtgggagccggtgacaaa	12	12	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:76736794G>A	uc003kff.1	-	9	1013	c.726C>T	c.(724-726)GTC>GTT	p.V242V	WDR41_uc011csy.1_Silent_p.V184V|WDR41_uc011csz.1_Silent_p.V187V|WDR41_uc011cta.1_RNA|WDR41_uc011ctb.1_RNA	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	242	WD 4.										0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		TCAGCTCTCCGACGTGGGAGC	0.453													0	0	0	1	0	11	27										A	76736794	G	A	76736794	2	1	100	1	0	0	0	0	0	0	0	1	17291	1045	37	1		1	WDR41	5	76736794	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2700965	76736794	104178466	270	30864										
SERINC5	256987	broad.mit.edu	37	chr5	79473155	79473155	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accgttcagaaaggtgtcctGatctggaatgaagaaagctc	11	8	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:79473155G>C	uc003kgj.2	-	4	568	c.439C>G	c.(439-441)CAG>GAG	p.Q147E	SERINC5_uc003kgk.2_Missense_Mutation_p.Q147E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.Q147E|SERINC5_uc011ctj.1_Missense_Mutation_p.Q147E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	147	Cytoplasmic (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		AAGGTGTCCTGATCTGGAATG	0.413													0	0	0	1	0	29	4										C	79473155	G	C	79473155	3	2	100	1	0	0	0	0	1	0	0	0	14083	1299	45	1	1020	1	SERINC5	5	79473155	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2736361	79473155	101442105	271	30865										
TTC37	9652	broad.mit.edu	37	chr5	94834293	94834293	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggttggttcctttaagataGagctgtaaagatattttaaa	9	3	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:94834293G>C	uc003klb.2	-	33	3614	c.3344C>G	c.(3343-3345)TCT>TGT	p.S1115C		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1115							binding			ovary(3)|pancreas(1)	4						CTTTAAGATAGAGCTGTAAAG	0.279													0	0	0	1	0	11	15										C	94834293	G	C	94834293	3	2	100	1	0	0	0	0	1	0	0	0	16702	942	33	1	1394	1	TTC37	5	94834293	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	15361138	94834293	86080967	272	30866										
GLRX	2745	broad.mit.edu	37	chr5	95158310	95158310	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagtacgggcaggtgggcttGatgaacacaaccaccttccc	11	13	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:95158310G>C	uc003klo.3	-	1	268	c.57C>G	c.(55-57)ATC>ATG	p.I19M	GLRX_uc003kln.3_Missense_Mutation_p.I19M	NM_001118890	NP_001112362	P35754	GLRX1_HUMAN	glutaredoxin (thioltransferase)	19	Glutaredoxin.				cell redox homeostasis|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|transport	cytosol	electron carrier activity|glutathione disulfide oxidoreductase activity|protein disulfide oxidoreductase activity|protein N-terminus binding				0		all_cancers(142;3.38e-06)|all_epithelial(76;5.66e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;2.62e-16)	Glutathione(DB00143)	AGGTGGGCTTGATGAACACAA	0.547													0	0	0	1	0	19	29										C	95158310	G	C	95158310	3	2	100	1	0	0	0	0	1	0	0	0	6459	1280	45	1	271	1	GLRX	5	95158310	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	324017	95158310	85756950	273	30867										
ERAP2	64167	broad.mit.edu	37	chr5	96219518	96219518	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcttgcagtaacagattttGagccaacccaggcacgcatg	9	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:96219518G>C	uc003kmq.2	+	3	1308	c.598G>C	c.(598-600)GAG>CAG	p.E200Q	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.E200Q|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.E194Q|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	200	Lumenal (Potential).	Substrate (By similarity).			antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		AACAGATTTTGAGCCAACCCA	0.433													0	0	0	1	0	15	18										C	96219518	G	C	96219518	3	2	100	1	0	0	0	0	1	0	0	0	5204	1291	45	1	604	1	ERAP2	5	96219518	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1061208	96219518	84695742	274	30868										
ERAP2	64167	broad.mit.edu	37	chr5	96249154	96249154	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagaaaattggacccatcttCtgaaaaagttggtattcatt	8	6	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:96249154C>T	uc003kmq.2	+	17	3360	c.2650C>T	c.(2650-2652)CTG>TTG	p.L884L	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Silent_p.L884L|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Silent_p.L833L|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	884	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GACCCATCTTCTGAAAAAGTT	0.413													0	0	0	1	0	7	15										T	96249154	C	T	96249154	2	4	100	1	0	0	0	0	0	0	0	1	5204	912	32	1		1	ERAP2	5	96249154	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	29636	96249154	84666106	275	30869										
RIOK2	55781	broad.mit.edu	37	chr5	96503580	96503580	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaatgagaattcagatccctCttttgtttcaatatttttat	4	6	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:96503580C>G	uc003kmz.2	-	8	1098	c.988G>C	c.(988-990)GAG>CAG	p.E330Q	RIOK2_uc003kna.3_Missense_Mutation_p.E330Q	NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	330	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TCAGATCCCTCTTTTGTTTCA	0.408													0	0	0	1	0	52	69										G	96503580	C	G	96503580	3	3	100	1	0	0	0	0	1	0	0	0	13378	922	32	1	710	1	RIOK2	5	96503580	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	254426	96503580	84411680	276	30870										
REEP5	7905	broad.mit.edu	37	chr5	112238167	112238167	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccatacactacccagtaggtCagccactgggtatcatcttc	7	14	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:112238167C>G	uc003kqe.1	-	3	405	c.261G>C	c.(259-261)CTG>CTC	p.L87L	REEP5_uc011cvw.1_Silent_p.L60L|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Silent_p.L87L|REEP5_uc011cvz.1_Intron	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	87						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		CCCAGTAGGTCAGCCACTGGG	0.398													0	0	0	1	0	13	28										G	112238167	C	G	112238167	2	3	100	1	0	0	0	0	0	0	0	1	13208	813	29	1		1	REEP5	5	112238167	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	15734587	112238167	68677093	277	30871										
LOX	4015	broad.mit.edu	37	chr5	121413262	121413262	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgtctggttctccgcgcgcGaggcgccagcttcgcgggct	15	15	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:121413262G>A	uc003ksu.2	-	1	794	c.419C>T	c.(418-420)TCG>TTG	p.S140L	LOX_uc010jcq.2_5'Flank|LOX_uc011cwk.1_5'Flank|LOX_uc010jcr.2_5'Flank	NM_002317	NP_002308	P28300	LYOX_HUMAN	lysyl oxidase preproprotein	140					protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			lung(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		CTCCGCGCGCGAGGCGCCAGC	0.692													0	0	0	1	0	14	3										A	121413262	G	A	121413262	3	1	100	1	0	0	0	0	1	0	0	0	8898	1059	37	1	862	1	LOX	5	121413262	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9175095	121413262	59501998	278	30872										
PRRC1	133619	broad.mit.edu	37	chr5	126862374	126862374	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctggcacagggaactggaacCacatcagccattactttccc	8	14	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:126862374C>T	uc003kuk.2	+	4	738	c.558C>T	c.(556-558)ACC>ACT	p.T186T	PRRC1_uc003kuj.3_Silent_p.T186T	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	186						Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GAACTGGAACCACATCAGCCA	0.413													0	0	0	1	0	16	17										T	126862374	C	T	126862374	2	4	100	1	0	0	0	0	0	0	0	1	12604	581	21	2		2	PRRC1	5	126862374	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5449112	126862374	54052886	279	30873										
EGR1	1958	broad.mit.edu	37	chr5	137801586	137801586	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgctgctgagcaacggggctCcccagttcctcggcgccgcc	13	17	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:137801586C>A	uc003ldb.1	+	1	406	c.136C>A	c.(136-138)CCC>ACC	p.P46T	EGR1_uc011cyu.1_Missense_Mutation_p.P46T	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	46					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAACGGGGCTCCCCAGTTCCT	0.433													1	0	2.40579e-17	1	2.66234e-17	37	2										A	137801586	C	A	137801586	3	1	100	1	0	0	0	0	1	0	0	0	4971	855	30	3	138	3	EGR1	5	137801586	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	10939212	137801586	43113674	280	30874										
PCDHB1	29930	broad.mit.edu	37	chr5	140432144	140432144	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctgaagactcaccaccacaGacagtagtagcccttttcac	6	15	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140432144G>C	uc003lik.1	+	1	1166	c.1089G>C	c.(1087-1089)CAG>CAC	p.Q363H		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	363	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCACCACAGACAGTAGTAG	0.502													0	0	0	1	0	19	31										C	140432144	G	C	140432144	3	2	100	1	0	0	0	0	1	0	0	0	11534	933	33	1	1091	1	PCDHB1	5	140432144	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2630558	140432144	40483116	281	30875										
PCDHB2	56133	broad.mit.edu	37	chr5	140476693	140476693	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagttcctgaagccaattatCcccaacttcgttgctcaggg	8	12	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140476693C>T	uc003lil.2	+	1	2457	c.2319C>T	c.(2317-2319)ATC>ATT	p.I773I	PCDHB2_uc003lim.1_Silent_p.I434I	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	773	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCAATTATCCCCAACTTCG	0.512													0	0	0	1	0	40	10										T	140476693	C	T	140476693	2	4	100	1	0	0	0	0	0	0	0	1	11542	845	30	1		1	PCDHB2	5	140476693	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	44549	140476693	40438567	282	30876										
PCDHB5	26167	broad.mit.edu	37	chr5	140516663	140516663	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggcgctggtgcgcgtgctGgtgctggacgccaacgacaa	17	11	0	0	rs149096993		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140516663G>A	uc003liq.2	+	1	1864	c.1647G>A	c.(1645-1647)CTG>CTA	p.L549L		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	549	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCGCGTGCTGGTGCTGGACG	0.721													0	0	0	1	0	21	37										A	140516663	G	A	140516663	2	1	100	1	0	0	0	0	0	0	0	1	11545	1335	47	2		2	PCDHB5	5	140516663	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	39970	140516663	40398597	283	30877										
PCDHGA7	56108	broad.mit.edu	37	chr5	140763490	140763490	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcacagttttagatgtaaatGataatgctccagaagtgact	8	6	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140763490G>A	uc003lka.1	+	1	1024	c.1024G>A	c.(1024-1026)GAT>AAT	p.D342N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D342N	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	342	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATGTAAATGATAATGCTCC	0.413													0	0	0	1	0	38	5										A	140763490	G	A	140763490	3	1	100	1	0	0	0	0	1	0	0	0	11559	1290	45	1	1026	1	PCDHGA7	5	140763490	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	246827	140763490	40151770	284	30878										
PCDHGA7	56108	broad.mit.edu	37	chr5	140763541	140763541	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	taagtagctcaatccctgaaGacacacctcttgggacagtc	8	12	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140763541G>A	uc003lka.1	+	1	1075	c.1075G>A	c.(1075-1077)GAC>AAC	p.D359N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D359N	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	359	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATCCCTGAAGACACACCTCT	0.418													0	0	0	1	0	26	4										A	140763541	G	A	140763541	3	1	100	1	0	0	0	0	1	0	0	0	11559	942	33	1	1077	1	PCDHGA7	5	140763541	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	51	140763541	40151719	285	30879										
SPINK5	11005	broad.mit.edu	37	chr5	147449904	147449904	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggaaatgtgccatgaatttCaggcatttatgaaaaatgga	10	4	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:147449904C>T	uc003lox.2	+	3	173	c.100C>T	c.(100-102)CAG>TAG	p.Q34*	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Nonsense_Mutation_p.Q6*|SPINK5_uc010jgr.2_Intron|SPINK5_uc003low.2_Nonsense_Mutation_p.Q34*|SPINK5_uc003loy.2_Nonsense_Mutation_p.Q34*	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	34	Kazal-like 1; atypical.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGAATTTCAGGCATTTAT	0.289													0	0	0	1	0	29	4										T	147449904	C	T	147449904	4	4	100	1	0	0	0	0	0	1	0	0	15061	827	29	1	110	1	SPINK5	5	147449904	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6686363	147449904	33465356	286	30880										
IL17B	27190	broad.mit.edu	37	chr5	148754083	148754083	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgctgcggtcctcctgcatgGtgaaggggttcacacagccc	13	13	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:148754083G>A	uc003lqo.2	-	3	442	c.392C>T	c.(391-393)ACC>ATC	p.T131I		NM_014443	NP_055258	Q9UHF5	IL17B_HUMAN	interleukin 17B precursor	131					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTGCATGGTGAAGGGGTT	0.682													0	0	0	1	0	18	17										A	148754083	G	A	148754083	3	1	100	1	0	0	0	0	1	0	0	0	7635	1261	44	2	154	2	IL17B	5	148754083	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1304179	148754083	32161177	287	30881										
SLC36A3	285641	broad.mit.edu	37	chr5	150660605	150660605	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaccaaggctgagcggacagAcaggtctacaaacagtgccc	12	12	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:150660605A>G	uc003ltw.2	-	9	1533	c.1114T>C	c.(1114-1116)TCT>CCT	p.S372P	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Missense_Mutation_p.S357P|SLC36A3_uc003ltx.2_Missense_Mutation_p.S413P	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	372	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGCGGACAGACAGGTCTACA	0.552													0	0	0	1	0	19	23										G	150660605	A	G	150660605	3	3	100	1	0	0	0	0	1	0	0	0	14595	275	10	5	306	5	SLC36A3	5	150660605	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1906522	150660605	30254655	288	30882										
GEMIN5	25929	broad.mit.edu	37	chr5	154268890	154268890	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttaactcttaccttaatgctCtcaggaaatttcgccattct	4	11	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:154268890C>G	uc003lvx.3	-	27	4433	c.4350G>C	c.(4348-4350)GAG>GAC	p.E1450D	GEMIN5_uc011ddk.1_Missense_Mutation_p.E1449D	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1450					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCTTAATGCTCTCAGGAAATT	0.368													0	0	0	1	0	13	16										G	154268890	C	G	154268890	3	3	100	1	0	0	0	0	1	0	0	0	6331	912	32	1	184	1	GEMIN5	5	154268890	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3608285	154268890	26646370	289	30883										
ITK	3702	broad.mit.edu	37	chr5	156659373	156659373	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtacaataagagtatcagccGagacaaagctgaaaaacttc	8	8	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:156659373G>A	uc003lwo.1	+	8	819	c.737G>A	c.(736-738)CGA>CAA	p.R246Q		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	246	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTATCAGCCGAGACAAAGCT	0.269			T	SYK	peripheral T-cell lymphoma								0	0	0	1	0	16	1										A	156659373	G	A	156659373	3	1	100	1	0	0	0	0	1	0	0	0	7909	1058	37	1	767	1	ITK	5	156659373	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2390483	156659373	24255887	290	30884										
STK10	6793	broad.mit.edu	37	chr5	171544538	171544538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgttgccagctttcagatctCggtggatgatcctcttgctg	11	11	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:171544538C>T	uc003mbo.1	-	4	767	c.467G>A	c.(466-468)CGA>CAA	p.R156Q		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	156	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTCAGATCTCGGTGGATGAT	0.597													0	0	0	1	0	16	19										T	171544538	C	T	171544538	3	4	100	1	0	0	0	0	1	0	0	0	15285	884	31	1	2503	1	STK10	5	171544538	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	14885165	171544538	9370722	291	30885										
UNC5A	90249	broad.mit.edu	37	chr5	176304229	176304229	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccccccagatgccataccccGagggaagatctatgagatct	9	14	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:176304229G>T	uc003mey.2	+	9	1607	c.1415G>T	c.(1414-1416)CGA>CTA	p.R472L		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	472	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCATACCCCGAGGGAAGATC	0.637													1	0	7.26314e-15	1	7.98553e-15	29	2										T	176304229	G	T	176304229	3	4	100	1	0	0	0	0	1	0	0	0	16988	1058	37	3	1449	3	UNC5A	5	176304229	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4759691	176304229	4611031	292	30886										
MAPK9	5601	broad.mit.edu	37	chr5	179707519	179707519	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtgaaggttgagtctgccaCttgcacactataaaactgac	9	9	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:179707519C>G	uc003mls.3	-	2	314	c.43G>C	c.(43-45)GTG>CTG	p.V15L	MAPK9_uc003mlt.3_Missense_Mutation_p.V15L|MAPK9_uc010jlc.2_Missense_Mutation_p.V15L|MAPK9_uc003mlv.3_Missense_Mutation_p.V15L|MAPK9_uc011dgx.1_Missense_Mutation_p.V15L	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	15					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGTCTGCCACTTGCACACTA	0.458													0	0	0	1	0	8	43										G	179707519	C	G	179707519	3	3	100	1	0	0	0	0	1	0	0	0	9287	565	20	4	1397	4	MAPK9	5	179707519	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3403290	179707519	1207741	293	30887										
ACOT13	55856	broad.mit.edu	37	chr6	24667557	24667557	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accaaggctcgcaattttgaGagagttttgggaaaggtatg	13	5	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:24667557G>C	uc003nek.2	+	1	295	c.66G>C	c.(64-66)GAG>GAC	p.E22D	TDP2_uc003nei.2_5'Flank|TDP2_uc003nej.2_5'Flank|TDP2_uc010jpu.1_5'Flank|ACOT13_uc010jpv.2_5'UTR	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	22					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						GCAATTTTGAGAGAGTTTTGG	0.502											OREG0017230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	13	29										C	24667557	G	C	24667557	3	2	100	1	0	0	0	0	1	0	0	0	151	933	33	1	68	1	ACOT13	6	24667557	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		24667557	146447510	294	30888										
FAM65B	9750	broad.mit.edu	37	chr6	24843425	24843425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attctcaaggaacaggtgctCagccccagcacctgaggact	10	13	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:24843425C>G	uc003neo.1	-	14	1761	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	FAM65B_uc011djs.1_Missense_Mutation_p.E508Q|FAM65B_uc011dju.1_Missense_Mutation_p.E513Q|FAM65B_uc003nep.2_Missense_Mutation_p.E479Q|FAM65B_uc011djt.1_Missense_Mutation_p.E479Q	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	529					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AACAGGTGCTCAGCCCCAGCA	0.572													0	0	0	1	0	18	68										G	24843425	C	G	24843425	3	3	100	1	0	0	0	0	1	0	0	0	5600	835	29	1	1671	1	FAM65B	6	24843425	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	175868	24843425	146271642	295	30889										
LRRC16A	55604	broad.mit.edu	37	chr6	25581557	25581557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catccctcagacaggagaagCggagctcgggatttatctct	11	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:25581557C>T	uc011djw.1	+	31	3272	c.2896C>T	c.(2896-2898)CGG>TGG	p.R966W	LRRC16A_uc010jpx.2_Missense_Mutation_p.R966W|LRRC16A_uc010jpy.2_Missense_Mutation_p.R966W	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	966	LRR 11.|Inhibits capping activity of CAPZA2 (By similarity).				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						ACAGGAGAAGCGGAGCTCGGG	0.463													0	0	0	1	0	15	5										T	25581557	C	T	25581557	3	4	100	1	0	0	0	0	1	0	0	0	8971	759	27	2	3018	2	LRRC16A	6	25581557	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	738132	25581557	145533510	296	30890										
DHX16	8449	broad.mit.edu	37	chr6	30624524	30624524	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acctgccctgccagctcgctGattggctgaggcctggaaag	13	13	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:30624524G>C	uc003nqz.2	-	14	2373	c.2161C>G	c.(2161-2163)CAG>GAG	p.Q721E	DHX16_uc003nqy.2_Missense_Mutation_p.Q240E|DHX16_uc011dmo.1_Missense_Mutation_p.Q661E	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	721	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CCAGCTCGCTGATTGGCTGAG	0.542													0	0	0	1	0	18	50										C	30624524	G	C	30624524	3	2	100	1	0	0	0	0	1	0	0	0	4502	1299	45	1	992	1	DHX16	6	30624524	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5042967	30624524	140490543	297	30891										
HLA-C	3107	broad.mit.edu	37	chr6	31237268	31237268	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacgcccgccgccatcacttAcacgcagcctgagagcagct	9	18	1	1	rs111308207		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:31237268A>C	uc003nsy.2	-	6	1055	c.1048_splice	c.e6+1	p.C350_splice	HLA-C_uc011dnj.1_Splice_Site_p.C322_splice|HLA-C_uc003nsx.2_Splice_Site_p.C229_splice|HLA-C_uc003nsz.2_Splice_Site_p.C356_splice|HLA-C_uc010jsl.2_Intron|HLA-C_uc003nta.2_Splice_Site_p.S350_splice|HLA-C_uc003ntb.2_Splice_Site|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Splice_Site	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						GCCATCACTTACACGCAGCCT	0.557													0	0	0	1	0	5	14										C	31237268	A	C	31237268	5	2	100	1	0	0	0	0	0	0	1	0	7197	405	14	5	62	5	HLA-C	6	31237268	Splice_Site	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	612744	31237268	139877799	298	30892										
TEAD3	7005	broad.mit.edu	37	chr6	35443426	35443426	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctatcagcagagctgtactGagagctgaccccatagaagg	12	10	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:35443426G>A	uc003oku.3	-	11	1194	c.958C>T	c.(958-960)CAG>TAG	p.Q320*	TEAD3_uc003okt.2_Nonsense_Mutation_p.Q209*|TEAD3_uc010jvx.2_Nonsense_Mutation_p.Q260*	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	320	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAGCTGTACTGAGAGCTGACC	0.612													0	0	0	1	0	18	39										A	35443426	G	A	35443426	4	1	100	1	0	0	0	0	0	1	0	0	15737	1299	45	1	361	1	TEAD3	6	35443426	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4206158	35443426	135671641	299	30893										
TULP1	7287	broad.mit.edu	37	chr6	35478728	35478728	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggaggcagaaggattttctCtttcttttcctctgcctcct	9	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:35478728C>G	uc003okv.3	-	5	421	c.409G>C	c.(409-411)GAG>CAG	p.E137Q	TULP1_uc003okw.3_Missense_Mutation_p.E84Q	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	137					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						AGGATTTTctctttcttttcc	0.408													0	0	0	1	0	19	31										G	35478728	C	G	35478728	3	3	100	1	0	0	0	0	1	0	0	0	16770	922	32	1	1263	1	TULP1	6	35478728	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	35302	35478728	135636339	300	30894										
LHFPL5	222662	broad.mit.edu	37	chr6	35773514	35773514	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaactatgtgcggaactcgCgagccgtgggcgtgatgtgg	16	10	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:35773514C>T	uc003olg.1	+	1	444	c.67C>T	c.(67-69)CGA>TGA	p.R23*		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	23						integral to membrane				skin(1)	1						GCGGAACTCGCGAGCCGTGGG	0.617													0	0	0	1	0	24	59										T	35773514	C	T	35773514	4	4	100	1	0	0	0	0	0	1	0	0	8768	760	27	2	69	2	LHFPL5	6	35773514	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	294786	35773514	135341553	301	30895										
BTBD9	114781	broad.mit.edu	37	chr6	38561774	38561774	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggaaaccttcacttgagaggActtcctgagcattcctatcc	8	12	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:38561774A>G	uc003ooa.3	-	4	1091	c.515T>C	c.(514-516)GTC>GCC	p.V172A	BTBD9_uc003ony.3_Missense_Mutation_p.V104A|BTBD9_uc010jwv.2_Missense_Mutation_p.V104A|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.V172A	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	172	BACK.				cell adhesion						0						ACTTGAGAGGACTTCCTGAGC	0.383													0	0	0	1	0	48	137										G	38561774	A	G	38561774	3	3	100	1	0	0	0	0	1	0	0	0	1548	275	10	5	1450	5	BTBD9	6	38561774	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	2788260	38561774	132553293	302	30896										
GLO1	2739	broad.mit.edu	37	chr6	38670780	38670780	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccgcgtcggagcagcaactGagggcggcctcgtccgtgag	16	13	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:38670780G>A	uc003ooc.2	-	1	173	c.51C>T	c.(49-51)CTC>CTT	p.L17L		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	17					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	AGCAGCAACTGAGGGCGGCCT	0.692													0	0	0	1	0	10	1										A	38670780	G	A	38670780	2	1	100	1	0	0	0	0	0	0	0	1	6449	1277	45	1		1	GLO1	6	38670780	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	109006	38670780	132444287	303	30897										
ZNF318	24149	broad.mit.edu	37	chr6	43322436	43322436	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcacggttcttctcatcaGagatcttctctggattatat	7	9	5	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:43322436G>C	uc003oux.2	-	4	2714	c.2636C>G	c.(2635-2637)TCT>TGT	p.S879C	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	879	Potential.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTTCTCATCAGAGATCTTCTC	0.438													0	0	0	1	0	67	5										C	43322436	G	C	43322436	3	2	100	1	0	0	0	0	1	0	0	0	17833	942	33	1	4231	1	ZNF318	6	43322436	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4651656	43322436	127792631	304	30898										
NFKBIE	4794	broad.mit.edu	37	chr6	44232769	44232769	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcttccagctgctgagggctCagcgcccccacgtgggggag	16	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:44232769C>G	uc003oxe.1	-	1	757	c.732G>C	c.(730-732)CTG>CTC	p.L244L		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	244					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GCTGAGGGCTCAGCGCCCCCA	0.662													0	0	0	1	0	3	2										G	44232769	C	G	44232769	2	3	100	1	0	0	0	0	0	0	0	1	10380	813	29	1		1	NFKBIE	6	44232769	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	910333	44232769	126882298	305	30899										
C6orf138	442213	broad.mit.edu	37	chr6	47847059	47847059	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgctgaaatatttctgctgAaccatggcataggaaacact	8	8	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:47847059A>C	uc011dwm.1	-	3	1555	c.1470T>G	c.(1468-1470)GTT>GTG	p.V490V	C6orf138_uc011dwn.1_Silent_p.V254V	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	507						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						ATTTCTGCTGAACCATGGCAT	0.478													0	0	0	1	0	9	3										C	47847059	A	C	47847059	2	2	100	1	0	0	0	0	0	0	0	1	2332	233	9	5		5	C6orf138	6	47847059	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	3614290	47847059	123268008	306	30900										
TFAP2D	83741	broad.mit.edu	37	chr6	50740451	50740451	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgctgaactacttggaaaaAcacactactcacaagaacgg	7	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:50740451A>G	uc003paf.2	+	8	1745	c.1233A>G	c.(1231-1233)AAA>AAG	p.K411K	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	411							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					ACTTGGAAAAACACACTACTC	0.502													0	0	0	1	0	16	28										G	50740451	A	G	50740451	2	3	100	1	0	0	0	0	0	0	0	1	15787	40	2	5		5	TFAP2D	6	50740451	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	2893392	50740451	120374616	307	30901										
GSTA2	2939	broad.mit.edu	37	chr6	52615459	52615459	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgccaggctgtagaaacttCttcactgtgggcaggttact	11	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:52615459C>G	uc003pay.2	-	7	735	c.585G>C	c.(583-585)AAG>AAC	p.K195N		NM_000846	NP_000837	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	195	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	GTAGAAACTTCTTCACTGTGG	0.453													0	0	0	1	0	54	38										G	52615459	C	G	52615459	3	3	100	1	0	0	0	0	1	0	0	0	6831	912	32	1	87	1	GSTA2	6	52615459	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1875008	52615459	118499608	308	30902										
BAI3	577	broad.mit.edu	37	chr6	69949067	69949067	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attaacttctgcctgtctatCatctcatccaatatcctcat	2	13	5	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:69949067C>T	uc003pev.3	+	20	3211	c.2763C>T	c.(2761-2763)ATC>ATT	p.I921I	BAI3_uc010kak.2_Silent_p.I921I|BAI3_uc011dxx.1_Silent_p.I127I|BAI3_uc003pex.1_Silent_p.I51I	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	921	Helical; Name=2; (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GCCTGTCTATCATCTCATCCA	0.353													0	0	0	1	0	37	44										T	69949067	C	T	69949067	2	4	100	1	0	0	0	0	0	0	0	1	1300	816	29	1		1	BAI3	6	69949067	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	17333608	69949067	101166000	309	30903										
COL9A1	1297	broad.mit.edu	37	chr6	70964891	70964891	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agggagaccaggaattcctcTagcaccttcagccccctgca	9	15	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:70964891T>G	uc003pfg.3	-	23	1732	c.1573A>C	c.(1573-1575)AGA>CGA	p.R525R	COL9A1_uc003pfe.3_Silent_p.R98R|COL9A1_uc003pff.3_Silent_p.R282R	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	525	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGAATTCCTCTAGCACCTTCA	0.443													0	0	0	1	0	37	55										G	70964891	T	G	70964891	2	3	100	1	0	0	0	0	0	0	0	1	3707	1530	53	5		5	COL9A1	6	70964891	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	1015824	70964891	100150176	310	30904										
BEND3	57673	broad.mit.edu	37	chr6	107391788	107391788	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gttggacgtgagggtgttcaGcatgtagaacatcttctgga	14	6	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:107391788G>C	uc003prs.2	-	5	1257	c.607C>G	c.(607-609)CTG>GTG	p.L203V		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	203										ovary(3)	3						AGGGTGTTCAGCATGTAGAAC	0.572													0	0	0	1	0	4	27										C	107391788	G	C	107391788	3	2	100	1	0	0	0	0	1	0	0	0	1399	962	34	4	1883	4	BEND3	6	107391788	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	36426897	107391788	63723279	311	30905										
MICAL1	64780	broad.mit.edu	37	chr6	109766413	109766413	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cactcactgctctggcgcctCaaggccagctccagcttcac	8	18	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:109766413C>T	uc003ptj.2	-	21	3122	c.2868G>A	c.(2866-2868)TTG>TTA	p.L956L	MICAL1_uc003ptk.2_Silent_p.L956L|MICAL1_uc010kdr.2_Silent_p.L870L|MICAL1_uc011eaq.1_Silent_p.L975L	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	956	Potential.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TCTGGCGCCTCAAGGCCAGCT	0.592													0	0	0	1	0	16	19										T	109766413	C	T	109766413	2	4	100	1	0	0	0	0	0	0	0	1	9569	825	29	1		1	MICAL1	6	109766413	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2374625	109766413	61348654	312	30906										
REV3L	5980	broad.mit.edu	37	chr6	111697217	111697217	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggcttttctgttttatgttCttgaaattcttcatacctaa	5	7	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:111697217C>T	uc003puy.3	-	13	2664	c.2341G>A	c.(2341-2343)GAA>AAA	p.E781K	REV3L_uc003pux.3_Missense_Mutation_p.E703K|REV3L_uc003puz.3_Missense_Mutation_p.E703K	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	781					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTTTTATGTTCTTGAAATTCT	0.378								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	23	33										T	111697217	C	T	111697217	3	4	100	1	0	0	0	0	1	0	0	0	13240	922	32	1	7131	1	REV3L	6	111697217	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1930804	111697217	59417850	313	30907										
C6orf225	619208	broad.mit.edu	37	chr6	112420507	112420507	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgccttttcaatttggaacCcagccaaggaggtttccagt	9	10	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:112420507C>A	uc003pvs.2	+	3	446	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_001033564	NP_001028736	Q4G0N7	CF225_HUMAN	hypothetical protein LOC619208	7											0						AATTTGGAACCCAGCCAAGGA	0.428													1	0	2.70639e-06	1	2.8172e-06	21	31										A	112420507	C	A	112420507	2	1	100	1	0	0	0	0	0	0	0	1	2358	610	22	4		4	C6orf225	6	112420507	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	723290	112420507	58694560	314	30908										
RFPL4B	442247	broad.mit.edu	37	chr6	112671551	112671561	+	Frame_Shift_Del	DEL	ACTTAGAAGAA	ACTTAGAAGAA	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggaattttcctggatgctgActtagaagaaatccagtttt							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:112671551_112671561delACTTAGAAGAA	uc003pvx.1	+	3	953_963	c.641_651delACTTAGAAGAA	c.(640-651)GACTTAGAAGAAfs	p.D214fs		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	214_217	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CTGGATGCTGACTTAGAAGAAATCCAGTTTT	0.455																		9	32	---	---								-	112671561	ACTTAGAAGAA	-	112671551	7	5	100	1	0	1	0	1	0	0	0	0	13256	275	10	0	643	0	RFPL4B	6	112671551	Frame_Shift_Del	DEL	ACTTAGAAGAA	TCGA-G2-A3VY-01A-11D-A22Z-08	251044	112671551	58443516	315	30909										
STX7	8417	broad.mit.edu	37	chr6	132785148	132785148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttacctgataatctgctgccCttgacagctgctgatttgct	8	11	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:132785148C>T	uc003qdg.2	-	9	927	c.677G>A	c.(676-678)AGG>AAG	p.R226K	STX7_uc011ecg.1_RNA|STX7_uc011ech.1_Missense_Mutation_p.R51K	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	226	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ATCTGCTGCCCTTGACAGCTG	0.393													0	0	0	1	0	28	35										T	132785148	C	T	132785148	3	4	100	1	0	0	0	0	1	0	0	0	15349	681	24	2	116	2	STX7	6	132785148	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	20113597	132785148	38329919	316	30910										
TAAR5	9038	broad.mit.edu	37	chr6	132910508	132910508	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggtaggtgtgcaggcggcaGaggaagtccccgaagaacca	16	9	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:132910508G>C	uc003qdk.2	-	1	370	c.318C>G	c.(316-318)CTC>CTG	p.L106L		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	106	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GCAGGCGGCAGAGGAAGTCCC	0.592													0	0	0	1	0	30	31										C	132910508	G	C	132910508	2	2	100	1	0	0	0	0	0	0	0	1	15488	929	33	1		1	TAAR5	6	132910508	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	125360	132910508	38204559	317	30911										
GRM1	2911	broad.mit.edu	37	chr6	146350756	146350756	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgctggcaggagcgtcgtctCagcgctcggtggccagaatg	16	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:146350756C>T	uc010khw.1	+	2	573	c.103C>T	c.(103-105)CAG>TAG	p.Q35*	GRM1_uc010khu.1_Nonsense_Mutation_p.Q35*|GRM1_uc010khv.1_Nonsense_Mutation_p.Q35*|GRM1_uc003qll.2_Nonsense_Mutation_p.Q35*|GRM1_uc011edz.1_Nonsense_Mutation_p.Q35*|GRM1_uc011eea.1_Nonsense_Mutation_p.Q35*	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	35	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGCGTCGTCTCAGCGCTCGGT	0.582													0	0	0	1	0	44	81										T	146350756	C	T	146350756	4	4	100	1	0	0	0	0	0	1	0	0	6796	827	29	1	105	1	GRM1	6	146350756	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	13440248	146350756	24764311	318	30912										
SYNE1	23345	broad.mit.edu	37	chr6	152583209	152583209	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agaacattctgtagtagtttCtgcttggtactaaattcttg	8	6	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:152583209C>G	uc010kiw.2	-	101	19532	c.18930G>C	c.(18928-18930)CAG>CAC	p.Q6310H	SYNE1_uc010kiv.2_Missense_Mutation_p.Q834H|SYNE1_uc003qos.3_Missense_Mutation_p.Q834H|SYNE1_uc003qot.3_Missense_Mutation_p.Q6239H|SYNE1_uc003qou.3_Missense_Mutation_p.Q6310H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6310	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTAGTAGTTTCTGCTTGGTAC	0.368										HNSCC(10;0.0054)			0	0	0	1	0	15	28										G	152583209	C	G	152583209	3	3	100	1	0	0	0	0	1	0	0	0	15442	912	32	1	7720	1	SYNE1	6	152583209	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6232453	152583209	18531858	319	30913										
SYNE1	23345	broad.mit.edu	37	chr6	152599392	152599392	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgataaagccaccaccttCtgctctatttccaccagcat	4	15	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:152599392C>G	uc010kiw.2	-	98	19007	c.18405G>C	c.(18403-18405)CAG>CAC	p.Q6135H	SYNE1_uc010kiv.2_Missense_Mutation_p.Q659H|SYNE1_uc003qos.3_Missense_Mutation_p.Q659H|SYNE1_uc003qot.3_Missense_Mutation_p.Q6064H|SYNE1_uc003qou.3_Missense_Mutation_p.Q6135H|SYNE1_uc010kiy.1_Missense_Mutation_p.Q314H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6135	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACCACCTTCTGCTCTATTT	0.498										HNSCC(10;0.0054)			0	0	0	1	0	6	95										G	152599392	C	G	152599392	3	3	100	1	0	0	0	0	1	0	0	0	15442	912	32	1	8257	1	SYNE1	6	152599392	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	16183	152599392	18515675	320	30914										
TAGAP	117289	broad.mit.edu	37	chr6	159457377	159457377	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggctgtttggttgtgggtttCacacccattttcctgcacga	11	10	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:159457377C>G	uc003qrz.2	-	10	2010	c.1678G>C	c.(1678-1680)GAA>CAA	p.E560Q	TAGAP_uc011eft.1_Missense_Mutation_p.E497Q|TAGAP_uc003qsa.2_Missense_Mutation_p.E382Q	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	560					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTGTGGGTTTCACACCCATTT	0.607													0	0	0	1	0	7	38										G	159457377	C	G	159457377	3	3	100	1	0	0	0	0	1	0	0	0	15534	835	29	1	521	1	TAGAP	6	159457377	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6857985	159457377	11657690	321	30915										
RPS6KA2	6196	broad.mit.edu	37	chr6	166923801	166923801	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatgaaggggtgattcacttCtgccaagatgtctctctcca	9	10	4	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:166923801C>T	uc003qvb.1	-	4	562	c.343G>A	c.(343-345)GAA>AAA	p.E115K	RPS6KA2_uc011ego.1_Missense_Mutation_p.E26K|RPS6KA2_uc010kkl.1_Missense_Mutation_p.E26K|RPS6KA2_uc003qvc.1_Missense_Mutation_p.E123K|RPS6KA2_uc003qvd.1_Missense_Mutation_p.E140K|MIR1913_hsa-mir-1913|MI0008334_5'Flank	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	115	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TGATTCACTTCTGCCAAGATG	0.423													0	0	0	1	0	16	26										T	166923801	C	T	166923801	3	4	100	1	0	0	0	0	1	0	0	0	13651	922	32	1	1930	1	RPS6KA2	6	166923801	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	7466424	166923801	4191266	322	30916										
MEOX2	4223	broad.mit.edu	37	chr7	15666538	15666538	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgacttgtaatttccttcctGggagtctgaaaaaaaaggga	10	6	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:15666538G>A	uc003stc.2	-	2	804	c.523C>T	c.(523-525)CAG>TAG	p.Q175*	MEOX2_uc011jxw.1_Nonsense_Mutation_p.Q175*	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	175					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TTTCCTTCCTGGGAGTCTGAA	0.363													0	0	0	1	0	14	60										A	15666538	G	A	15666538	4	1	100	1	0	0	0	0	0	1	0	0	9474	1357	47	2	399	2	MEOX2	7	15666538	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		15666538	143472125	323	30917										
HOXA10	3206	broad.mit.edu	37	chr7	27211618	27211618	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaaaccagattttcacttgtCtgtccgtgaggtggacgctg	12	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:27211618C>T	uc011jzm.1	-	2	1163	c.1133G>A	c.(1132-1134)AGA>AAA	p.R378K	MIR196B_hsa-mir-196b|MI0001150_5'Flank|HOXA10_uc003syw.3_Missense_Mutation_p.R62K	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	378	Homeobox.				spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTTCACTTGTCTGTCCGTGAG	0.483													0	0	0	1	0	27	84										T	27211618	C	T	27211618	3	4	100	1	0	0	0	0	1	0	0	0	7289	913	32	1	103	1	HOXA10	7	27211618	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11545080	27211618	131927045	324	30918										
ANLN	54443	broad.mit.edu	37	chr7	36438741	36438741	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aacgctgttctgacaacactGaagtagaagtttctaacttg	8	8	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:36438741G>A	uc003tff.2	+	3	430	c.226G>A	c.(226-228)GAA>AAA	p.E76K	ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Missense_Mutation_p.E76K|ANLN_uc010kxe.2_Missense_Mutation_p.E76K	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	76	Nuclear localization.|Interaction with CD2AP.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TGACAACACTGAAGTAGAAGT	0.373													0	0	0	1	0	11	31										A	36438741	G	A	36438741	3	1	100	1	0	0	0	0	1	0	0	0	694	1291	45	1	236	1	ANLN	7	36438741	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9227123	36438741	122699922	325	30919										
AEBP1	165	broad.mit.edu	37	chr7	44144280	44144280	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggccatggcggccgtgcgcGgggcgcccctgctcagctgc	17	17	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:44144280G>T	uc003tkb.2	+	1	321	c.16G>T	c.(16-18)GGG>TGG	p.G6W		NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	6					cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ggccgtgcgcggggcgccccT	0.368													1	0	0.004672	1	0.00472309	3	4										T	44144280	G	T	44144280	3	4	100	1	0	0	0	0	1	0	0	0	349	1116	39	4	18	4	AEBP1	7	44144280	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7705539	44144280	114994383	326	30920										
ABCA13	154664	broad.mit.edu	37	chr7	48450206	48450206	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccagcatgggaggctcaggTgctgcggtcctcccttctgc	13	14	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:48450206T>C	uc003toq.2	+	40	12185	c.12160T>C	c.(12160-12162)TGC>CGC	p.C4054R	ABCA13_uc010kys.1_Missense_Mutation_p.C1128R|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4054	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAGGCTCAGGTGCTGCGGTCC	0.597													0	0	0	1	0	46	83										C	48450206	T	C	48450206	3	2	100	1	0	0	0	0	1	0	0	0	31	1696	59	5	12147	5	ABCA13	7	48450206	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	4305926	48450206	110688457	327	30921										
ABCB4	5244	broad.mit.edu	37	chr7	87060748	87060748	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgacaagtttgaagtacaccCcttccttcttcatcagttcg	6	12	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:87060748C>A	uc003uiv.1	-	15	1941	c.1865G>T	c.(1864-1866)GGG>GTG	p.G622V	ABCB4_uc003uiw.1_Missense_Mutation_p.G622V|ABCB4_uc003uix.1_Missense_Mutation_p.G622V	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	622	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GAAGTACACCCCTTCCTTCTT	0.413													1	0	3.52763e-06	1	3.66456e-06	18	113										A	87060748	C	A	87060748	3	1	100	1	0	0	0	0	1	0	0	0	43	623	22	4	2051	4	ABCB4	7	87060748	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	38610542	87060748	72077915	328	30922										
SLC25A40	55972	broad.mit.edu	37	chr7	87485664	87485664	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttaacaacatccaggggtgTcactatgaagatatgttaag	9	6	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:87485664T>A	uc003uje.2	-	4	451	c.100A>T	c.(100-102)ACA>TCA	p.T34S		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	34	Solcar 1.|Helical; Name=1; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					TCCAGGGGTGTCACTATGAAG	0.343													0	0	0	1	0	23	155										A	87485664	T	A	87485664	3	1	100	1	0	0	0	0	1	0	0	0	14505	1667	58	5	952	5	SLC25A40	7	87485664	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	424916	87485664	71652999	329	30923										
ADAM22	53616	broad.mit.edu	37	chr7	87743932	87743932	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacgggaaccacacatatctCattgagccagaagaaaatga	9	9	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:87743932C>G	uc003ujn.2	+	6	586	c.507C>G	c.(505-507)CTC>CTG	p.L169L	ADAM22_uc003uji.1_Silent_p.L168L|ADAM22_uc003ujj.1_Silent_p.L169L|ADAM22_uc003ujk.1_Silent_p.L169L|ADAM22_uc003ujl.1_Silent_p.L169L|ADAM22_uc003ujm.2_Silent_p.L169L|ADAM22_uc003ujo.2_Silent_p.L169L|ADAM22_uc003ujp.1_Silent_p.L221L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	169					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ACACATATCTCATTGAGCCAG	0.398													0	0	0	1	0	11	59										G	87743932	C	G	87743932	2	3	100	1	0	0	0	0	0	0	0	1	244	813	29	1		1	ADAM22	7	87743932	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	258268	87743932	71394731	330	30924										
HEPACAM2	253012	broad.mit.edu	37	chr7	92848468	92848468	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tagagttccatttccctgaaTgttgaccttcacgatgtaat	7	9	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:92848468T>A	uc003umm.2	-	2	399	c.376A>T	c.(376-378)ATT>TTT	p.I126F	HEPACAM2_uc003uml.2_Missense_Mutation_p.I114F|HEPACAM2_uc010lff.2_Missense_Mutation_p.I114F|HEPACAM2_uc011khy.1_Missense_Mutation_p.I149F	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	126	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TTTCCCTGAATGTTGACCTTC	0.443													0	0	0	1	0	23	72										A	92848468	T	A	92848468	3	1	100	1	0	0	0	0	1	0	0	0	7053	1464	51	5	1048	5	HEPACAM2	7	92848468	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	5104536	92848468	66290195	331	30925										
PEG10	23089	broad.mit.edu	37	chr7	94293033	94293033	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaacccacccctgaggatgaGgatgatgacatcgagctccg	12	12	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:94293033G>A	uc011kie.1	+	2	610	c.393G>A	c.(391-393)GAG>GAA	p.E131E		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	55					apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CTGAGGATGAGGATGATGACA	0.587													0	0	0	1	0	3	20										A	94293033	G	A	94293033	2	1	100	1	0	0	0	0	0	0	0	1	11719	1001	35	2		2	PEG10	7	94293033	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1444565	94293033	64845630	332	30926										
C7orf43	55262	broad.mit.edu	37	chr7	99755004	99755004	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agccctgcttacccttgagcAcggtcaagtgttttccagcc	9	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:99755004A>T	uc003utr.2	-	4	896	c.716T>A	c.(715-717)GTG>GAG	p.V239E	C7orf43_uc010lgo.2_5'Flank|C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'UTR|C7orf43_uc003uts.2_5'UTR	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	239											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACCCTTGAGCACGGTCAAGTG	0.632											OREG0018198	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	41										T	99755004	A	T	99755004	3	4	100	1	0	0	0	0	1	0	0	0	2393	159	6	5	1058	5	C7orf43	7	99755004	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	5461971	99755004	59383659	333	30927										
AP1S1	1174	broad.mit.edu	37	chr7	100802372	100802372	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacatcatcttcaactttgaGaaggcctacttcatcctgga	7	11	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:100802372G>A	uc003uxv.3	+	4	434	c.324G>A	c.(322-324)GAG>GAA	p.E108E		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	108					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TCAACTTTGAGAAGGCCTACT	0.552													0	0	0	1	0	6	45										A	100802372	G	A	100802372	2	1	100	1	0	0	0	0	0	0	0	1	736	933	33	1		1	AP1S1	7	100802372	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1047368	100802372	58336291	334	30928										
VGF	7425	broad.mit.edu	37	chr7	100808035	100808035	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagctgagaggaggaggctgCgcctcagggcgaccaggggg	21	9	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:100808035C>T	uc003uxx.3	-	2	308	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	30					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGGAGGCTGCGCCTCAGGGC	0.652													0	0	0	1	0	4	21										T	100808035	C	T	100808035	2	4	100	1	0	0	0	0	0	0	0	1	17154	755	27	2		2	VGF	7	100808035	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5663	100808035	58330628	335	30929										
PSMC2	5701	broad.mit.edu	37	chr7	102996214	102996214	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagataagcagacactccaGagtgaacagcctttacaggt	10	10	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:102996214G>C	uc003vbs.2	+	4	334	c.264G>C	c.(262-264)CAG>CAC	p.Q88H	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011kln.1_Missense_Mutation_p.Q88H|PSMC2_uc011klo.1_Intron	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	88					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AGACACTCCAGAGTGAACAGC	0.453													0	0	0	1	0	31	22										C	102996214	G	C	102996214	3	2	100	1	0	0	0	0	1	0	0	0	12686	933	33	1	278	1	PSMC2	7	102996214	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2188179	102996214	56142449	336	30930										
MLL5	55904	broad.mit.edu	37	chr7	104748167	104748167	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccaacttgagggacctgaCaccctcgcatcagttggagg	11	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:104748167C>T	uc003vcm.2	+	22	3797	c.3263C>T	c.(3262-3264)ACA>ATA	p.T1088I	MLL5_uc010ljc.2_Missense_Mutation_p.T1088I|MLL5_uc010lje.1_RNA|MLL5_uc010ljf.1_RNA|MLL5_uc010ljg.2_5'UTR|MLL5_uc010ljh.1_5'Flank	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1088					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AGGGACCTGACACCCTCGCAT	0.493													0	0	0	1	0	4	42										T	104748167	C	T	104748167	3	4	100	1	0	0	0	0	1	0	0	0	9624	478	17	2	3341	2	MLL5	7	104748167	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1751953	104748167	54390496	337	30931										
LAMB1	3912	broad.mit.edu	37	chr7	107564523	107564523	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttgattgtcttcatattttCtttctaaatctgtggggaga	8	5	5	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:107564523C>G	uc003vew.2	-	34	5569	c.5234G>C	c.(5233-5235)AGA>ACA	p.R1745T	LAMB1_uc003vev.2_Missense_Mutation_p.R1769T|LAMB1_uc003veu.2_Missense_Mutation_p.R228T	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1745	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCATATTTTCTTTCTAAATC	0.303													0	0	0	1	0	29	17										G	107564523	C	G	107564523	3	3	100	1	0	0	0	0	1	0	0	0	8610	913	32	1	130	1	LAMB1	7	107564523	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2816356	107564523	51574140	338	30932										
LAMB1	3912	broad.mit.edu	37	chr7	107566684	107566684	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tactactttttcaatatattCtgcctccccggagttttggg	7	10	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:107566684C>G	uc003vew.2	-	32	5343	c.5008G>C	c.(5008-5010)GAA>CAA	p.E1670Q	LAMB1_uc003vev.2_Missense_Mutation_p.E1694Q|LAMB1_uc003veu.2_Missense_Mutation_p.E153Q	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1670	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAATATATTCTGCCTCCCCG	0.423													0	0	0	1	0	15	81										G	107566684	C	G	107566684	3	3	100	1	0	0	0	0	1	0	0	0	8610	922	32	1	364	1	LAMB1	7	107566684	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2161	107566684	51571979	339	30933										
NRCAM	4897	broad.mit.edu	37	chr7	107849877	107849877	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caatatacctttaactctaaCagaaatggtatggtggatgg	9	6	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:107849877C>G	uc003vfb.2	-	12	1534	c.1063G>C	c.(1063-1065)GTT>CTT	p.V355L	NRCAM_uc003vfc.2_Missense_Mutation_p.V349L|NRCAM_uc011kmk.1_Missense_Mutation_p.V350L|NRCAM_uc003vfd.2_Missense_Mutation_p.V331L|NRCAM_uc003vfe.2_Missense_Mutation_p.V331L	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	355	Ig-like 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TTAACTCTAACAGAAATGGTA	0.338													0	0	0	1	0	47	61										G	107849877	C	G	107849877	3	3	100	1	0	0	0	0	1	0	0	0	10644	478	17	4	2969	4	NRCAM	7	107849877	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	283193	107849877	51288786	340	30934										
FOXP2	93986	broad.mit.edu	37	chr7	114299708	114299708	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggacatttgcttacttcaggCgtaatgcagcaacttggaag	11	8	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:114299708C>T	uc003vhb.2	+	13	2001	c.1627C>T	c.(1627-1629)CGT>TGT	p.R543C	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.R568C|FOXP2_uc003vha.2_Missense_Mutation_p.R451C|FOXP2_uc011kmu.1_Missense_Mutation_p.R560C|FOXP2_uc011kmv.1_Missense_Mutation_p.R542C|FOXP2_uc010ljz.1_Missense_Mutation_p.R358C|FOXP2_uc003vhe.1_Missense_Mutation_p.R113C	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	543	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TTACTTCAGGCGTAATGCAGC	0.318													0	0	0	1	0	17	91										T	114299708	C	T	114299708	3	4	100	1	0	0	0	0	1	0	0	0	6027	768	27	2	1840	2	FOXP2	7	114299708	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6449831	114299708	44838955	341	30935										
CFTR	1080	broad.mit.edu	37	chr7	117232152	117232152	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccagactttagctcaaaacTcatgggatgtgattctttcg	9	9	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:117232152T>C	uc003vjd.2	+	14	2063	c.1931T>C	c.(1930-1932)CTC>CCC	p.L644P	CFTR_uc011knq.1_Missense_Mutation_p.L50P	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	644	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AGCTCAAAACTCATGGGATGT	0.373									Cystic_Fibrosis				0	0	0	1	0	23	86										C	117232152	T	C	117232152	3	2	100	1	0	0	0	0	1	0	0	0	3294	1551	54	5	1985	5	CFTR	7	117232152	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	2932444	117232152	41906511	342	30936										
AASS	10157	broad.mit.edu	37	chr7	121773712	121773712	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccggacggccaacacagcTttgtggtgaagacccttgga	12	12	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:121773712T>A	uc003vka.2	-	1	165	c.69A>T	c.(67-69)AAA>AAT	p.K23N	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.K23N|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	23					protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCAACACAGCTTTGTGGTGAA	0.557													0	0	0	1	0	107	72										A	121773712	T	A	121773712	3	1	100	1	0	0	0	0	1	0	0	0	24	1606	56	5	2803	5	AASS	7	121773712	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	4541560	121773712	37364951	343	30937										
RNF148	378925	broad.mit.edu	37	chr7	122342732	122342732	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtcaggaaagctaagtagtaGaaagatactaagcctcaaaa	9	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:122342732G>C	uc003vkk.1	-	1	290	c.73C>G	c.(73-75)CTA>GTA	p.L25V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF148_uc010lkr.1_Missense_Mutation_p.L25V	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	25						integral to membrane	zinc ion binding				0						CTAAGTAGTAGAAAGATACTA	0.403													0	0	0	1	0	5	27										C	122342732	G	C	122342732	3	2	100	1	0	0	0	0	1	0	0	0	13449	933	33	1	848	1	RNF148	7	122342732	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	569020	122342732	36795931	344	30938										
SLC13A1	6561	broad.mit.edu	37	chr7	122839945	122839945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggtagtaaaaccaacacaGtgaaaaccacgaagagaaat	9	7	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:122839945G>A	uc003vkm.2	-	1	81	c.56C>T	c.(55-57)ACT>ATT	p.T19I	SLC13A1_uc010lks.2_5'UTR	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	19	Helical; (Potential).					integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	AACCAACACAGTGAAAACCAC	0.433													0	0	0	1	0	25	21										A	122839945	G	A	122839945	3	1	100	1	0	0	0	0	1	0	0	0	14391	1029	36	2	1791	2	SLC13A1	7	122839945	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	497213	122839945	36298718	345	30939										
IQUB	154865	broad.mit.edu	37	chr7	123152297	123152297	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgactcttgaggctcttctGagggaactggaatagtgaca	12	8	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:123152297G>C	uc003vkn.2	-	2	675	c.98C>G	c.(97-99)TCA>TGA	p.S33*	IQUB_uc003vko.2_Nonsense_Mutation_p.S33*|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Nonsense_Mutation_p.S33*|IQUB_uc003vkq.2_Nonsense_Mutation_p.S33*	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	33										ovary(3)|large_intestine(1)	4						AGGCTCTTCTGAGGGAACTGG	0.398													0	0	0	1	0	20	133										C	123152297	G	C	123152297	4	2	100	1	0	0	0	0	0	1	0	0	7820	1294	45	1	2325	1	IQUB	7	123152297	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	312352	123152297	35986366	346	30940										
SPAM1	6677	broad.mit.edu	37	chr7	123594167	123594167	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caaaatgtacaacttagtctCacagaggccactgagaaagc	8	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:123594167C>G	uc003vld.2	+	4	945	c.543C>G	c.(541-543)CTC>CTG	p.L181L	SPAM1_uc003vle.2_Silent_p.L181L|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Silent_p.L181L|SPAM1_uc010lku.2_Silent_p.L181L	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	181					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AACTTAGTCTCACAGAGGCCA	0.388													0	0	0	1	0	22	71										G	123594167	C	G	123594167	2	3	100	1	0	0	0	0	0	0	0	1	14986	813	29	1		1	SPAM1	7	123594167	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	441870	123594167	35544496	347	30941										
ZNF800	168850	broad.mit.edu	37	chr7	127014383	127014383	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcttaaaagattttttaggaGaaatagaatccaggaacaaa	7	4	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:127014383G>A	uc003vlx.1	-	5	1270	c.1007C>T	c.(1006-1008)TCT>TTT	p.S336F	ZNF800_uc003vlw.1_Missense_Mutation_p.S239F|ZNF800_uc003vly.1_Missense_Mutation_p.S336F|ZNF800_uc010lla.2_Missense_Mutation_p.S336F	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTTTTAGGAGAAATAGAATC	0.373													0	0	0	1	0	35	59										A	127014383	G	A	127014383	3	1	100	1	0	0	0	0	1	0	0	0	18166	942	33	1	995	1	ZNF800	7	127014383	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3420216	127014383	32124280	348	30942										
CALU	813	broad.mit.edu	37	chr7	128407602	128407602	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtttcgggataagaaccgtGatgggaagatggacaaggaa	15	4	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:128407602G>A	uc003vns.2	+	6	888	c.736G>A	c.(736-738)GAT>AAT	p.D246N	CALU_uc003vnq.2_Missense_Mutation_p.D246N|CALU_uc003vnr.2_Missense_Mutation_p.D246N	NM_001130674	NP_001124146	O43852	CALU_HUMAN	calumenin isoform b precursor	246	EF-hand 5.|5 (Potential).				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding				0						TAAGAACCGTGATGGGAAGAT	0.493													0	0	0	1	0	18	88										A	128407602	G	A	128407602	3	1	100	1	0	0	0	0	1	0	0	0	2594	1290	45	1	952	1	CALU	7	128407602	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1393219	128407602	30731061	349	30943										
NUP205	23165	broad.mit.edu	37	chr7	135303333	135303333	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgattattcgtgatattttAcaagatgtgcatgataaggt	9	4	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:135303333A>C	uc003vsw.2	+	28	3976	c.3945A>C	c.(3943-3945)TTA>TTC	p.L1315F	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1315					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GTGATATTTTACAAGATGTGC	0.378													0	0	0	1	0	29	141										C	135303333	A	C	135303333	3	2	100	1	0	0	0	0	1	0	0	0	10759	388	14	5	4055	5	NUP205	7	135303333	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	6895731	135303333	23835330	350	30944										
DGKI	9162	broad.mit.edu	37	chr7	137271945	137271945	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agttcatccaggatggaaagGatccagcccacctacaggcg	11	12	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:137271945G>C	uc003vtt.2	-	13	1324	c.1323C>G	c.(1321-1323)ATC>ATG	p.I441M	DGKI_uc003vtu.2_Missense_Mutation_p.I141M	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	441	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GGATGGAAAGGATCCAGCCCA	0.517													0	0	0	1	0	35	27										C	137271945	G	C	137271945	3	2	100	1	0	0	0	0	1	0	0	0	4471	1164	41	1	1962	1	DGKI	7	137271945	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1968612	137271945	21866718	351	30945										
KIAA1549	57670	broad.mit.edu	37	chr7	138588413	138588413	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaacctcgctgagcagctggGccagcttgcgttccatctcg	11	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:138588413G>A	uc011kql.1	-	8	3639	c.3590C>T	c.(3589-3591)GCC>GTC	p.A1197V	KIAA1549_uc003vuk.3_Missense_Mutation_p.A1147V|KIAA1549_uc011kqj.1_Missense_Mutation_p.A1197V	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1197						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GAGCAGCTGGGCCAGCTTGCG	0.532			O	BRAF	pilocytic astrocytoma								0	0	0	1	0	6	21										A	138588413	G	A	138588413	3	1	100	1	0	0	0	0	1	0	0	0	8244	1203	42	2	2314	2	KIAA1549	7	138588413	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1316468	138588413	20550250	352	30946										
TBXAS1	6916	broad.mit.edu	37	chr7	139715540	139715540	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagattcacacgggaggcagCtcaggactgcgaggtgctgg	16	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:139715540C>G	uc011kqv.1	+	12	1549	c.1385C>G	c.(1384-1386)GCT>GGT	p.A462G	TBXAS1_uc003vvh.2_Missense_Mutation_p.A416G|TBXAS1_uc010lne.2_Missense_Mutation_p.A348G|TBXAS1_uc011kqu.1_Missense_Mutation_p.A367G|TBXAS1_uc003vvi.2_Missense_Mutation_p.A416G|TBXAS1_uc003vvj.2_Missense_Mutation_p.A416G|TBXAS1_uc011kqw.1_Missense_Mutation_p.A396G	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	415	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					CGGGAGGCAGCTCAGGACTGC	0.647													0	0	0	1	0	13	85										G	139715540	C	G	139715540	3	3	100	1	0	0	0	0	1	0	0	0	15661	797	28	4	1431	4	TBXAS1	7	139715540	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1127127	139715540	19423123	353	30947										
PRSS1	5644	broad.mit.edu	37	chr7	142459637	142459637	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccatcagccgcatccaggtGagactgggagagcacaacat	11	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:142459637G>A	uc003wak.2	+	3	230	c.213G>A	c.(211-213)GTG>GTA	p.V71V	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Silent_p.V11V	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	71	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GCATCCAGGTGAGACTGGGAG	0.577									Hereditary_Pancreatitis				0	0	0	1	0	12	198										A	142459637	G	A	142459637	2	1	100	1	0	0	0	0	0	0	0	1	12614	1277	45	1		1	PRSS1	7	142459637	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2744097	142459637	16679026	354	30948										
TAS2R40	259286	broad.mit.edu	37	chr7	142919411	142919411	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgatgctggagaacattttCagtctgctattccgaattgt	9	7	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:142919411C>A	uc011ksx.1	+	1	240	c.240C>A	c.(238-240)TTC>TTA	p.F80L		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	80	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					AGAACATTTTCAGTCTGCTAT	0.448													1	0	2.48779e-11	1	2.68302e-11	27	83										A	142919411	C	A	142919411	3	1	100	1	0	0	0	0	1	0	0	0	15575	825	29	3	242	3	TAS2R40	7	142919411	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	459774	142919411	16219252	355	30949										
OR2A14	135941	broad.mit.edu	37	chr7	143826871	143826871	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcctacttgcgcatcctggcCgccatcttgaggatccagtc	9	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:143826871C>T	uc011kua.1	+	1	666	c.666C>T	c.(664-666)GCC>GCT	p.A222A		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GCATCCTGGCCGCCATCTTGA	0.612													0	0	0	1	0	114	124										T	143826871	C	T	143826871	2	4	100	1	0	0	0	0	0	0	0	1	10976	639	23	2		2	OR2A14	7	143826871	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	907460	143826871	15311792	356	30950										
CUL1	8454	broad.mit.edu	37	chr7	148463737	148463737	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgaattagcaaggaaatgtGaacaagtcctcattgaaaaa	8	5	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:148463737G>A	uc010lpg.2	+	8	1400	c.874G>A	c.(874-876)GAA>AAA	p.E292K	CUL1_uc003wey.2_Missense_Mutation_p.E292K|CUL1_uc003wez.2_Missense_Mutation_p.E182K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	292					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AAGGAAATGTGAACAAGTCCT	0.378													0	0	0	1	0	14	54										A	148463737	G	A	148463737	3	1	100	1	0	0	0	0	1	0	0	0	4054	1291	45	1	900	1	CUL1	7	148463737	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4636866	148463737	10674926	357	30951										
PDIA4	9601	broad.mit.edu	37	chr7	148702271	148702271	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caaactcgcggagggtgtcaGagtcaaactcctctggctcc	11	13	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:148702271G>C	uc003wff.2	-	9	1766	c.1484C>G	c.(1483-1485)TCT>TGT	p.S495C		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	495					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			GAGGGTGTCAGAGTCAAACTC	0.597													0	0	0	1	0	8	155										C	148702271	G	C	148702271	3	2	100	1	0	0	0	0	1	0	0	0	11670	942	33	1	461	1	PDIA4	7	148702271	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	238534	148702271	10436392	358	30952										
ABCB8	11194	broad.mit.edu	37	chr7	150737621	150737621	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgcaggtgcccgggtctttGagtacatggccctgaacccc	13	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:150737621G>C	uc003wil.3	+	12	1432	c.1339G>C	c.(1339-1341)GAG>CAG	p.E447Q	ABCB8_uc010lpw.1_Missense_Mutation_p.E319Q|ABCB8_uc010lpx.2_Missense_Mutation_p.E430Q|ABCB8_uc011kvd.1_Missense_Mutation_p.E342Q|ABCB8_uc003wim.3_Missense_Mutation_p.E225Q|ABCB8_uc003wik.3_Missense_Mutation_p.E430Q	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	447						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGGGTCTTTGAGTACATGGC	0.622													0	0	0	1	0	33	46										C	150737621	G	C	150737621	3	2	100	1	0	0	0	0	1	0	0	0	47	1291	45	1	1330	1	ABCB8	7	150737621	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2035350	150737621	8401042	359	30953										
ABCB8	11194	broad.mit.edu	37	chr7	150737667	150737667	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccactgtctgggggctgctGcgtccccaaagagcagctgc	13	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:150737667G>T	uc003wil.3	+	12	1478	c.1385G>T	c.(1384-1386)TGC>TTC	p.C462F	ABCB8_uc010lpw.1_Missense_Mutation_p.C334F|ABCB8_uc010lpx.2_Missense_Mutation_p.C445F|ABCB8_uc011kvd.1_Missense_Mutation_p.C357F|ABCB8_uc003wim.3_Missense_Mutation_p.C240F|ABCB8_uc003wik.3_Missense_Mutation_p.C445F	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	462						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGGGCTGCTGCGTCCCCAAA	0.647													1	0	1.42033e-22	1	1.59083e-22	34	48										T	150737667	G	T	150737667	3	4	100	1	0	0	0	0	1	0	0	0	47	1319	46	4	1376	4	ABCB8	7	150737667	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	46	150737667	8400996	360	30954										
CDK5	1020	broad.mit.edu	37	chr7	150751123	150751134	+	In_Frame_Del	DEL	GGGGTGCTGCAG	GGGGTGCTGCAG	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggacagaagtcggagaagtaGgggtgctgcagggcctcttc					rs11541602		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:150751123_150751134delGGGGTGCTGCAG	uc003wir.1	-	12	902_913	c.841_852delCTGCAGCACCCC	c.(841-852)CTGCAGCACCCCdel	p.LQHP281del		NM_004935	NP_004926	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5 isoform 1	281_284	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			lung(1)|central_nervous_system(1)	2		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CGGAGAAGTAGGGGTGCTGCAGGGCCTCTTCT	0.623																		5	8	---	---								-	150751134	GGGGTGCTGCAG	-	150751123	7	5	100	1	0	1	0	1	0	0	0	0	3142	987	35	0	30	0	CDK5	7	150751123	In_Frame_Del	DEL	GGGGTGCTGCAG	TCGA-G2-A3VY-01A-11D-A22Z-08	13456	150751123	8387540	361	30955										
MLL3	58508	broad.mit.edu	37	chr7	151962147	151962147	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agttctggcacactttgcacTcaggacattgccaacctgca	8	13	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:151962147T>A	uc003wla.2	-	8	1379	c.1160A>T	c.(1159-1161)GAG>GTG	p.E387V		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	387	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CACTTTGCACTCAGGACATTG	0.413			N		medulloblastoma								0	0	0	1	0	22	241										A	151962147	T	A	151962147	3	1	100	1	0	0	0	0	1	0	0	0	9622	1551	54	5	13783	5	MLL3	7	151962147	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	1211024	151962147	7176516	362	30956										
RBM33	155435	broad.mit.edu	37	chr7	155534734	155534734	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agaagctcacagggaaagacGgaagtgaaagtcaagccagc	13	8	2	3	rs113181766		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:155534734G>A	uc010lqk.1	+	13	2639	c.2271G>A	c.(2269-2271)ACG>ACA	p.T757T	RBM33_uc011kvv.1_Silent_p.T566T	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	757							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		AGGGAAAGACGGAAGTGAAAG	0.547													0	0	0	1	0	9	41										A	155534734	G	A	155534734	2	1	100	1	0	0	0	0	0	0	0	1	13130	1103	39	2		2	RBM33	7	155534734	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3572587	155534734	3603929	363	30957										
CSMD1	64478	broad.mit.edu	37	chr8	3009031	3009031	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgctcagcgtccctccacaGgttgctgttaagtggacaag	12	11	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:3009031G>T	uc011kwk.1	-	40	6312	c.5922C>A	c.(5920-5922)ACC>ACA	p.T1974T	CSMD1_uc011kwj.1_Silent_p.T1366T|CSMD1_uc003wqe.2_Silent_p.T1130T|CSMD1_uc010lrg.2_Silent_p.T42T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1974	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCCTCCACAGGTTGCTGTTA	0.527													1	0	0.00909568	1	0.00914966	3	2										T	3009031	G	T	3009031	2	4	100	1	0	0	0	0	0	0	0	1	3944	987	35	4		4	CSMD1	8	3009031	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		3009031	143354991	364	30958										
PNOC	5368	broad.mit.edu	37	chr8	28196682	28196682	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagcatgtggcggctgctctCtaccagccgagagcttcgga	14	12	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:28196682C>A	uc010lva.2	+	3	460	c.252C>A	c.(250-252)CTC>CTA	p.L84L	PNOC_uc003xgp.2_Silent_p.L84L|PNOC_uc011lau.1_Silent_p.L20L	NM_006228	NP_006219	Q13519	PNOC_HUMAN	prepronociceptin precursor	84					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)	1		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		CGGCTGCTCTCTACCAGCCGA	0.652													1	0	7.45023e-12	1	8.06909e-12	20	4										A	28196682	C	A	28196682	2	1	100	1	0	0	0	0	0	0	0	1	12162	900	32	3		3	PNOC	8	28196682	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	25187651	28196682	118167340	365	30959										
KCNU1	157855	broad.mit.edu	37	chr8	36697995	36697995	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttccaggttatgcctaaacaGacctggaagaaacacttctt	7	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:36697995G>C	uc010lvw.2	+	15	1620	c.1533G>C	c.(1531-1533)CAG>CAC	p.Q511H	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	511	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TGCCTAAACAGACCTGGAAGA	0.403													0	0	0	1	0	5	34										C	36697995	G	C	36697995	3	2	100	1	0	0	0	0	1	0	0	0	8093	933	33	1	1591	1	KCNU1	8	36697995	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8501313	36697995	109666027	366	30960										
UBE2V2	7336	broad.mit.edu	37	chr8	48973350	48973350	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtccaaagaaaatatgaagCttccacagccaccagaagga	8	10	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:48973350C>G	uc003xqm.2	+	4	421	c.400C>G	c.(400-402)CTT>GTT	p.L134V		NM_003350	NP_003341	Q15819	UB2V2_HUMAN	ubiquitin-conjugating enzyme E2v2	134					cell proliferation|DNA double-strand break processing|protein polyubiquitination|regulation of DNA repair	cytoplasm|nucleus|UBC13-MMS2 complex	acid-amino acid ligase activity|protein binding				0		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00171)|all_lung(136;0.00196)				AAATATGAAGCTTCCACAGCC	0.353								Direct_reversal_of_damage|Rad6_pathway					0	0	0	1	0	13	79										G	48973350	C	G	48973350	3	3	100	1	0	0	0	0	1	0	0	0	16873	797	28	4	414	4	UBE2V2	8	48973350	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	12275355	48973350	97390672	367	30961										
CHD7	55636	broad.mit.edu	37	chr8	61654316	61654316	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actcgcagtatcacacccctCccgttcctcaggtgccccat	6	19	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:61654316C>A	uc003xue.2	+	2	802	c.325C>A	c.(325-327)CCC>ACC	p.P109T		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	109					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCACACCCCTCCCGTTCCTCA	0.567													1	0	2.32078e-09	1	2.46887e-09	16	20										A	61654316	C	A	61654316	3	1	100	1	0	0	0	0	1	0	0	0	3330	855	30	3	327	3	CHD7	8	61654316	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	12680966	61654316	84709706	368	30962										
DNAJC5B	85479	broad.mit.edu	37	chr8	66963882	66963882	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ataagggagcatcaaatgaaGaaattaagaaaacctacagg	9	5	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:66963882G>C	uc003xvs.1	+	3	391	c.100G>C	c.(100-102)GAA>CAA	p.E34Q	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	34	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			ATCAAATGAAGAAATTAAGAA	0.393													0	0	0	1	0	13	99										C	66963882	G	C	66963882	3	2	100	1	0	0	0	0	1	0	0	0	4651	943	33	1	102	1	DNAJC5B	8	66963882	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5309566	66963882	79400140	369	30963										
CPA6	57094	broad.mit.edu	37	chr8	68536432	68536432	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttaagttgataggatattttCttcagtgcatatgcttcctc	7	7	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:68536432C>T	uc003xxq.3	-	2	427	c.171G>A	c.(169-171)AAG>AAA	p.K57K	CPA6_uc003xxr.3_5'UTR|CPA6_uc003xxs.2_Silent_p.K57K	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	57					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AGGATATTTTCTTCAGTGCAT	0.318													0	0	0	1	0	37	15										T	68536432	C	T	68536432	2	4	100	1	0	0	0	0	0	0	0	1	3794	912	32	1		1	CPA6	8	68536432	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1572550	68536432	77827590	370	30964										
C8orf34	116328	broad.mit.edu	37	chr8	69358655	69358656	+	Frame_Shift_Del	DEL	TG	TG	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaatcaaaaagtgaccttgcTgtgtctaatatttctccacc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:69358655_69358656delTG	uc010lyz.2	+	3	358_359	c.309_310delTG	c.(307-312)GCTGTGfs	p.A103fs	C8orf34_uc010lyx.1_Frame_Shift_Del_p.A103fs|C8orf34_uc010lyy.1_Frame_Shift_Del_p.A103fs|C8orf34_uc003xyb.2_Frame_Shift_Del_p.A78fs	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	103_104					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GTGACCTTGCTGTGTCTAATAT	0.337																		13	59	---	---								-	69358656	TG	-	69358655	7	5	100	1	0	1	0	1	0	0	0	0	2422	1567	55	0	240	0	C8orf34	8	69358655	Frame_Shift_Del	DEL	TG	TCGA-G2-A3VY-01A-11D-A22Z-08	822223	69358655	77005367	371	30965										
SLCO5A1	81796	broad.mit.edu	37	chr8	70650368	70650368	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcagttacaatggcactctCagctgtgtatgacaaactca	8	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:70650368C>A	uc003xyl.2	-	5	2037	c.1330G>T	c.(1330-1332)GAG>TAG	p.E444*	SLCO5A1_uc010lzb.2_Intron|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Nonsense_Mutation_p.E444*|SLCO5A1_uc010lzc.2_Intron	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	444	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ATGGCACTCTCAGCTGTGTAT	0.423													1	0	2.48254e-18	1	2.75928e-18	51	35										A	70650368	C	A	70650368	4	1	100	1	0	0	0	0	0	1	0	0	14731	835	29	3	1240	3	SLCO5A1	8	70650368	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1291713	70650368	75713654	372	30966										
TRAM1	23471	broad.mit.edu	37	chr8	71520314	71520314	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gactcggggcgggctcacctCaaacatgagccccagcagga	13	14	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:71520314C>G	uc003xyo.1	-	1	291	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	TRAM1_uc011lfc.1_Missense_Mutation_p.E10Q	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	41	Helical; (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GGGCTCACCTCAAACATGAGC	0.692													0	0	0	1	0	19	4										G	71520314	C	G	71520314	3	3	100	1	0	0	0	0	1	0	0	0	16448	835	29	1	1047	1	TRAM1	8	71520314	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	869946	71520314	74843708	373	30967										
LACTB2	51110	broad.mit.edu	37	chr8	71550853	71550853	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttagccatttcatgtaaattCtcaggagtattctaaaagaa	6	6	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:71550853C>G	uc011lfd.1	-	6	845	c.753G>C	c.(751-753)GAG>GAC	p.E251D	LACTB2_uc003xyp.2_Missense_Mutation_p.E251D	NM_016027	NP_057111	Q53H82	LACB2_HUMAN	lactamase, beta 2	251							hydrolase activity|metal ion binding			ovary(1)	1	Breast(64;0.0716)		Epithelial(68;0.00319)|all cancers(69;0.0175)|OV - Ovarian serous cystadenocarcinoma(28;0.0628)|BRCA - Breast invasive adenocarcinoma(89;0.166)			CATGTAAATTCTCAGGAGTAT	0.244													0	0	0	1	0	34	18										G	71550853	C	G	71550853	3	3	100	1	0	0	0	0	1	0	0	0	8598	912	32	1	121	1	LACTB2	8	71550853	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	30539	71550853	74813169	374	30968										
PI15	51050	broad.mit.edu	37	chr8	75737667	75737667	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagccaggcggaagcgctaCatttcgcagaatgacatgat	11	9	0	3	rs147092656	by1000genomes	TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:75737667C>T	uc003yal.2	+	2	362	c.183C>T	c.(181-183)TAC>TAT	p.Y61Y	uc003yak.1_Intron|PI15_uc003yam.2_Silent_p.Y61Y	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	61						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GGAAGCGCTACATTTCGCAGA	0.443													0	0	0	1	0	49	42										T	75737667	C	T	75737667	2	4	100	1	0	0	0	0	0	0	0	1	11868	489	17	2		2	PI15	8	75737667	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4186814	75737667	70626355	375	30969										
RALYL	138046	broad.mit.edu	37	chr8	85441685	85441685	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacattgaagccattttttcAaagtatggaaaaatagttgg	9	4	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:85441685A>G	uc003ycq.3	+	3	545	c.129A>G	c.(127-129)TCA>TCG	p.S43S	RALYL_uc003ycr.3_Silent_p.S43S|RALYL_uc003ycs.3_Silent_p.S43S|RALYL_uc010lzy.2_Silent_p.S43S|RALYL_uc003yct.3_Silent_p.S56S	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	43	RRM.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCATTTTTTCAAAGTATGGAA	0.408													0	0	0	1	0	16	17										G	85441685	A	G	85441685	2	3	100	1	0	0	0	0	0	0	0	1	13020	117	5	5		5	RALYL	8	85441685	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	9704018	85441685	60922337	376	30970										
PSKH2	85481	broad.mit.edu	37	chr8	87076268	87076268	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctttcatcatcaaaaggcaGgaatccgctaagtaaagcat	8	9	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:87076268G>A	uc011lfy.1	-	2	778	c.778C>T	c.(778-780)CTG>TTG	p.L260L		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	260	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			TCAAAAGGCAGGAATCCGCTA	0.403													0	0	0	1	0	37	41										A	87076268	G	A	87076268	2	1	100	1	0	0	0	0	0	0	0	1	12665	991	35	2		2	PSKH2	8	87076268	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1634583	87076268	59287754	377	30971										
POP1	10940	broad.mit.edu	37	chr8	99142401	99142401	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccttggggagaggccaacaGtcaagagccacagagcctgc	14	12	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:99142401G>C	uc003yij.3	+	5	782	c.682G>C	c.(682-684)GTC>CTC	p.V228L	POP1_uc011lgv.1_Missense_Mutation_p.V228L|POP1_uc003yik.2_Missense_Mutation_p.V228L	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	228					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GAGGCCAACAGTCAAGAGCCA	0.483													0	0	0	1	0	31	95										C	99142401	G	C	99142401	3	2	100	1	0	0	0	0	1	0	0	0	12251	1029	36	4	696	4	POP1	8	99142401	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	12066133	99142401	47221621	378	30972										
VPS13B	157680	broad.mit.edu	37	chr8	100844696	100844696	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttgctgggacttgatgcctGacatcagtcagtcagtactg	11	10	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:100844696G>C	uc003yiv.2	+	52	9616	c.9505G>C	c.(9505-9507)GAC>CAC	p.D3169H	VPS13B_uc003yiw.2_Missense_Mutation_p.D3144H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3169					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTTGATGCCTGACATCAGTCA	0.522													0	0	0	1	0	16	30										C	100844696	G	C	100844696	3	2	100	1	0	0	0	0	1	0	0	0	17187	1290	45	1	9901	1	VPS13B	8	100844696	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1702295	100844696	45519326	379	30973										
VPS13B	157680	broad.mit.edu	37	chr8	100866115	100866115	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atattaatgagttcagctttGaattaaaacctgctcggtta	7	6	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:100866115G>A	uc003yiv.2	+	56	10684	c.10573G>A	c.(10573-10575)GAA>AAA	p.E3525K	VPS13B_uc003yiw.2_Missense_Mutation_p.E3500K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3525					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTTCAGCTTTGAATTAAAACC	0.383													0	0	0	1	0	41	178										A	100866115	G	A	100866115	3	1	100	1	0	0	0	0	1	0	0	0	17187	1291	45	1	10985	1	VPS13B	8	100866115	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	21419	100866115	45497907	380	30974										
SPAG1	6674	broad.mit.edu	37	chr8	101253173	101253173	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agctaattgaacagctgtttGaggacctttcggacacacca	9	10	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:101253173G>C	uc003yjh.1	+	19	2790	c.2704G>C	c.(2704-2706)GAG>CAG	p.E902Q	SPAG1_uc003yji.1_Missense_Mutation_p.E902Q	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	902					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		ACAGCTGTTTGAGGACCTTTC	0.333													0	0	0	1	0	10	112										C	101253173	G	C	101253173	3	2	100	1	0	0	0	0	1	0	0	0	14975	1291	45	1	2774	1	SPAG1	8	101253173	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	387058	101253173	45110849	381	30975										
YWHAZ	7534	broad.mit.edu	37	chr8	101936227	101936245	+	Frame_Shift_Del	DEL	TGTATGACTCTTCACTTAA	TGTATGACTCTTCACTTAA	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cattattagcgtgctgtcttTgtatgactcttcacttaatg							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:101936227_101936245delTGTATGACTCTTCACTTAA	uc011lhe.1	-	5	793_811	c.616_634delTTAAGTGAAGAGTCATACA	c.(616-636)TTAAGTGAAGAGTCATACAAAfs	p.L206fs	YWHAZ_uc003yjv.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc011lhf.1_Frame_Shift_Del_p.L206fs|YWHAZ_uc003yjw.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc010mbq.2_Frame_Shift_Del_p.L129fs|YWHAZ_uc011lhg.1_Frame_Shift_Del_p.L86fs|YWHAZ_uc010mbr.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc003yjx.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc003yjy.2_Frame_Shift_Del_p.L206fs	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	206_212					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	GTGCTGTCTTTGTATGACTCTTCACTTAATGTATCAAGT	0.333																		16	155	---	---								-	101936245	TGTATGACTCTTCACTTAA	-	101936227	7	5	100	1	0	1	0	1	0	0	0	0	17503	1821	63	0	111	0	YWHAZ	8	101936227	Frame_Shift_Del	DEL	TGTATGACTCTTCACTTAA	TCGA-G2-A3VY-01A-11D-A22Z-08	683054	101936227	44427795	382	30976										
UBR5	51366	broad.mit.edu	37	chr8	103298599	103298599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagacttgcctgctggtgtaGatgtactggaaggggctgta	15	7	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:103298599G>C	uc003ykr.1	-	38	5237	c.5204C>G	c.(5203-5205)TCT>TGT	p.S1735C	UBR5_uc003yks.1_Missense_Mutation_p.S1735C	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1735					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGCTGGTGTAGATGTACTGGA	0.453													0	0	0	1	0	5	61										C	103298599	G	C	103298599	3	2	100	1	0	0	0	0	1	0	0	0	16902	942	33	1	3283	1	UBR5	8	103298599	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1362372	103298599	43065423	383	30977										
FZD6	8323	broad.mit.edu	37	chr8	104337017	104337017	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aattgatgttagaagattcaGatacccagagagaccaatta	8	6	1	6			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:104337017G>A	uc003ylh.2	+	4	967	c.683G>A	c.(682-684)AGA>AAA	p.R228K	FZD6_uc003yli.2_Missense_Mutation_p.R228K|FZD6_uc003ylj.2_Missense_Mutation_p.R228K|FZD6_uc011lhn.1_Missense_Mutation_p.R194K|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Missense_Mutation_p.R173K	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	228	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			AGAAGATTCAGATACCCAGAG	0.338													0	0	0	1	0	26	57										A	104337017	G	A	104337017	3	1	100	1	0	0	0	0	1	0	0	0	6134	942	33	1	693	1	FZD6	8	104337017	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1038418	104337017	42027005	384	30978										
RIMS2	9699	broad.mit.edu	37	chr8	104955043	104955043	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cattattagatgatgagccaCattggtacaaacttcagacg	8	8	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:104955043C>T	uc003yls.2	+	12	2165	c.1924C>T	c.(1924-1926)CAT>TAT	p.H642Y	RIMS2_uc003ylp.2_Missense_Mutation_p.H864Y|RIMS2_uc003ylw.2_Missense_Mutation_p.H656Y|RIMS2_uc003ylq.2_Missense_Mutation_p.H656Y|RIMS2_uc003ylr.2_Missense_Mutation_p.H703Y|RIMS2_uc003ylt.2_Missense_Mutation_p.H249Y	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	926					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGATGAGCCACATTGGTACAA	0.393										HNSCC(12;0.0054)			0	0	0	1	0	11	62										T	104955043	C	T	104955043	3	4	100	1	0	0	0	0	1	0	0	0	13368	478	17	2	2770	2	RIMS2	8	104955043	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	618026	104955043	41408979	385	30979										
ZFPM2	23414	broad.mit.edu	37	chr8	106815184	106815184	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attgctacaaaagaagaaaaCagacatttgtttcttccaca	5	8	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:106815184C>G	uc003ymd.2	+	8	2897	c.2874C>G	c.(2872-2874)AAC>AAG	p.N958K	ZFPM2_uc011lhs.1_Missense_Mutation_p.N689K	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	958					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAGAAGAAAACAGACATTTGT	0.428													0	0	0	1	0	7	30										G	106815184	C	G	106815184	3	3	100	1	0	0	0	0	1	0	0	0	17655	477	17	4	2904	4	ZFPM2	8	106815184	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1860141	106815184	39548838	386	30980										
TAF2	6873	broad.mit.edu	37	chr8	120768248	120768248	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaatccctgctctctcaccaGaattcataagtttccaaagt	4	12	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:120768248G>A	uc003you.2	-	22	3146	c.2876C>T	c.(2875-2877)TCT>TTT	p.S959F		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	959					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TCTCTCACCAGAATTCATAAG	0.323													0	0	0	1	0	29	75										A	120768248	G	A	120768248	3	1	100	1	0	0	0	0	1	0	0	0	15521	942	33	1	743	1	TAF2	8	120768248	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	13953064	120768248	25595774	387	30981										
MTBP	27085	broad.mit.edu	37	chr8	121483136	121483144	+	In_Frame_Del	DEL	AATGGAAGG	AATGGAAGG	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caaccaactcagttcaagaaAatggaaggaatatatagcta							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:121483136_121483144delAATGGAAGG	uc003ypc.1	+	11	1169_1177	c.1124_1132delAATGGAAGG	c.(1123-1134)AAATGGAAGGAA>AAA	p.WKE376del	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	376_378					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AGTTCAAGAAAATGGAAGGAATATATAGC	0.33																		9	125	---	---								-	121483144	AATGGAAGG	-	121483136	7	5	100	1	0	1	0	1	0	0	0	0	9912	14	1	0	1166	0	MTBP	8	121483136	In_Frame_Del	DEL	AATGGAAGG	TCGA-G2-A3VY-01A-11D-A22Z-08	714888	121483136	24880886	388	30982										
WDR67	93594	broad.mit.edu	37	chr8	124109655	124109655	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccatctggaatttcttcctGatagttttgatgctggttct	9	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124109655G>C	uc003ypp.1	+	6	895	c.805G>C	c.(805-807)GAT>CAT	p.D269H	WDR67_uc011lig.1_Missense_Mutation_p.D269H|WDR67_uc011lih.1_Missense_Mutation_p.D159H|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Missense_Mutation_p.D269H|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	269						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTCTTCCTGATAGTTTTGA	0.398													0	0	0	1	0	5	72										C	124109655	G	C	124109655	3	2	100	1	0	0	0	0	1	0	0	0	17315	1290	45	1	827	1	WDR67	8	124109655	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2626519	124109655	22254367	389	30983										
C8orf76	84933	broad.mit.edu	37	chr8	124243745	124243745	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttttcctgagtgtggaaagaAggatttgatagttttgtcac	11	4	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124243745A>C	uc003yqc.1	-	4	641	c.610T>G	c.(610-612)TTC>GTC	p.F204V	C8orf76_uc003yqd.2_Missense_Mutation_p.F172V	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	204							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGTGGAAAGAAGGATTTGATA	0.448													0	0	0	1	0	75	97										C	124243745	A	C	124243745	3	2	100	1	0	0	0	0	1	0	0	0	2437	72	3	5	544	5	C8orf76	8	124243745	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	134090	124243745	22120277	390	30984										
ZHX1	11244	broad.mit.edu	37	chr8	124267094	124267094	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggaataacagttatggtctGaggtacagtatgcactgttc	11	6	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124267094G>C	uc003yqe.2	-	3	1523	c.1093C>G	c.(1093-1095)CAG>GAG	p.Q365E	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.Q365E|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.Q365E	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	365	Required for dimerization.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GTTATGGTCTGAGGTACAGTA	0.433													0	0	0	1	0	38	241										C	124267094	G	C	124267094	3	2	100	1	0	0	0	0	1	0	0	0	17672	1299	45	1	1532	1	ZHX1	8	124267094	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	23349	124267094	22096928	391	30985										
WDYHV1	55093	broad.mit.edu	37	chr8	124453558	124453558	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttttttagattccaaaatgaAcctgaacgatttcatcagta	5	7	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124453558A>G	uc003yqn.1	+	6	646	c.521A>G	c.(520-522)AAC>AGC	p.N174S	WDYHV1_uc011lij.1_Missense_Mutation_p.N114S|WDYHV1_uc003yqo.1_RNA	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	174					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						TCCAAAATGAACCTGAACGAT	0.368													0	0	0	1	0	120	47										G	124453558	A	G	124453558	3	3	100	1	0	0	0	0	1	0	0	0	17340	43	2	5	543	5	WDYHV1	8	124453558	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	186464	124453558	21910464	392	30986										
RNF139	11236	broad.mit.edu	37	chr8	125487416	125487416	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagcaggtctgggcggcgctCgaagtggcgctccgggtgcc	18	13	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:125487416C>G	uc003yrc.2	+	1	409	c.66C>G	c.(64-66)CTC>CTG	p.L22L	uc003yrb.2_5'Flank	NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	22					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GGGCGGCGCTCGAAGTGGCGC	0.632									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	1	0	8	71										G	125487416	C	G	125487416	2	3	100	1	0	0	0	0	0	0	0	1	13442	871	31	1		1	RNF139	8	125487416	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1033858	125487416	20876606	393	30987										
RNF139	11236	broad.mit.edu	37	chr8	125499414	125499414	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctacatgcatattttaacatCtacttacaagccaaaaatgg	4	9	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:125499414C>G	uc003yrc.2	+	2	1867	c.1524C>G	c.(1522-1524)ATC>ATG	p.I508M		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	508	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ATTTTAACATCTACTTACAAG	0.378									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	1	0	20	151										G	125499414	C	G	125499414	3	3	100	1	0	0	0	0	1	0	0	0	13442	903	32	1	1530	1	RNF139	8	125499414	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11998	125499414	20864608	394	30988										
ASAP1	50807	broad.mit.edu	37	chr8	131140337	131140337	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgtcaatactgatatccatCtgttggtaaaaacataagag	7	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:131140337C>T	uc003yta.1	-	15	1246	c.1218_splice	c.e15-1	p.A406_splice	ASAP1_uc003ysz.1_Splice_Site_p.A217_splice|ASAP1_uc011liw.1_Splice_Site_p.A399_splice	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor						cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TGATATCCATCTGTTGGTAAA	0.363													0	0	0	1	0	25	37										T	131140337	C	T	131140337	5	4	100	1	0	0	0	0	0	0	1	0	1010	927	32	1	2232	1	ASAP1	8	131140337	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5640923	131140337	15223685	395	30989										
TG	7038	broad.mit.edu	37	chr8	133879281	133879281	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagatcttcaccctgctggcCtccatctgctgggtgtcggc	12	14	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:133879281C>T	uc003ytw.2	+	1	77	c.36C>T	c.(34-36)GCC>GCT	p.A12A		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	12					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCTGCTGGCCTCCATCTGCT	0.547													0	0	0	1	0	3	8										T	133879281	C	T	133879281	2	4	100	1	0	0	0	0	0	0	0	1	15810	668	24	2		2	TG	8	133879281	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2738944	133879281	12484741	396	30990										
SLA	6503	broad.mit.edu	37	chr8	134057253	134057253	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atagtggttcaccaggtcctCcaggcactggaaggtgagcc	13	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:134057253C>G	uc003ytz.2	-	7	1292	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Missense_Mutation_p.E171Q|SLA_uc011ljf.1_Missense_Mutation_p.E46Q|SLA_uc011ljg.1_Intron|SLA_uc011ljd.1_Missense_Mutation_p.E194Q	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	154	SH2.					endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			ACCAGGTCCTCCAGGCACTGG	0.517													0	0	0	1	0	8	92										G	134057253	C	G	134057253	3	3	100	1	0	0	0	0	1	0	0	0	14363	864	30	1	382	1	SLA	8	134057253	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	177972	134057253	12306769	397	30991										
TG	7038	broad.mit.edu	37	chr8	134108561	134108561	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctttatgggtagaggtcgatCtgctcattgggagttctcag	13	7	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:134108561C>T	uc003ytw.2	+	43	7557	c.7516C>T	c.(7516-7518)CTG>TTG	p.L2506L	TG_uc010mdw.2_Silent_p.L1265L|TG_uc011ljb.1_Silent_p.L875L|TG_uc011ljc.1_Silent_p.L639L|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2506					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGAGGTCGATCTGCTCATTGG	0.577													0	0	0	1	0	26	237										T	134108561	C	T	134108561	2	4	100	1	0	0	0	0	0	0	0	1	15810	912	32	1		1	TG	8	134108561	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	51308	134108561	12255461	398	30992										
TRAPPC9	83696	broad.mit.edu	37	chr8	140744407	140744407	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcccacctggcaggccgccaCagcctcgcggtcacatggct	12	18	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:140744407C>T	uc003yvj.2	-	22	3228	c.3094G>A	c.(3094-3096)GTG>ATG	p.V1032M	TRAPPC9_uc003yvh.2_Missense_Mutation_p.V1130M	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	1032					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CAGGCCGCCACAGCCTCGCGG	0.716													0	0	0	1	0	11	17										T	140744407	C	T	140744407	3	4	100	1	0	0	0	0	1	0	0	0	16462	478	17	2	360	2	TRAPPC9	8	140744407	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6635846	140744407	5619615	399	30993										
CHRAC1	54108	broad.mit.edu	37	chr8	141525224	141525224	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtacgctttatgtttttaaGatatattaccaaagaagatt	6	4	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:141525224G>C	uc003yvl.2	+	3	473	c.275_splice	c.e3-1	p.D92_splice	CHRAC1_uc010mem.1_Splice_Site	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1						chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			ATGTTTTTAAGATATATTACC	0.333													0	0	0	1	0	14	204										C	141525224	G	C	141525224	5	2	100	1	0	0	0	0	0	0	1	0	3371	956	33	1	284	1	CHRAC1	8	141525224	Splice_Site	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	780817	141525224	4838798	400	30994										
FAM83H	286077	broad.mit.edu	37	chr8	144810771	144810771	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcgggccagggccgcggccGagggcacaagcggctcggac	19	14	0	0	rs137854442		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:144810771G>A	uc003yzk.2	-	5	929	c.860C>T	c.(859-861)TCG>TTG	p.S287L	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	287					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGCCGCGGCCGAGGGCACAAG	0.711													0	0	0	1	0	6	12										A	144810771	G	A	144810771	3	1	100	1	0	0	0	0	1	0	0	0	5640	1059	37	1	2683	1	FAM83H	8	144810771	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3285547	144810771	1553251	401	30995										
FAM83H	286077	broad.mit.edu	37	chr8	144812730	144812730	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgggttgtccccctgcgagGagctctgagagcgacgggcc	17	12	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:144812730G>A	uc003yzk.2	-	2	92	c.23C>T	c.(22-24)TCC>TTC	p.S8F	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	8					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCCCTGCGAGGAGCTCTGAGA	0.677													0	0	0	1	0	8	24										A	144812730	G	A	144812730	3	1	100	1	0	0	0	0	1	0	0	0	5640	1174	41	1	3532	1	FAM83H	8	144812730	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1959	144812730	1551292	402	30996										
EPPK1	83481	broad.mit.edu	37	chr8	144942543	144942543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cattcctgctttgaacgcctCctccacggtcagcttccggt	8	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:144942543C>T	uc003zaa.1	-	1	4892	c.4879G>A	c.(4879-4881)GAG>AAG	p.E1627K		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1627	Plectin 27.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TTGAACGCCTCCTCCACGGTC	0.637													0	0	0	1	0	22	65										T	144942543	C	T	144942543	3	4	100	1	0	0	0	0	1	0	0	0	5190	864	30	1	2387	1	EPPK1	8	144942543	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	129813	144942543	1421479	403	30997										
PARP10	84875	broad.mit.edu	37	chr8	145059158	145059158	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcccagagaccccatgggacCtgtcctcagagaggtccctg	11	15	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:145059158C>G	uc003zal.3	-	5	1120	c.1012G>C	c.(1012-1014)GGT>CGT	p.G338R	PARP10_uc003zak.3_Missense_Mutation_p.G44R|PARP10_uc011lku.1_Missense_Mutation_p.G350R|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.G338R|PARP10_uc010mfn.1_Missense_Mutation_p.G253R|PARP10_uc010mfo.1_3'UTR	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	338						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCATGGGACCTGTCCTCAGA	0.612													0	0	0	1	0	65	68										G	145059158	C	G	145059158	3	3	100	1	0	0	0	0	1	0	0	0	11455	681	24	4	2093	4	PARP10	8	145059158	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	116615	145059158	1304864	404	30998										
GPAA1	8733	broad.mit.edu	37	chr8	145140309	145140309	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagcacttcccagtggcaGaggctgaggctgtggtgctg	15	12	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:145140309G>T	uc003zax.2	+	10	1488	c.1378G>T	c.(1378-1380)GAG>TAG	p.E460*		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	460	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCAGTGGCAGAGGCTGAGGC	0.632													1	0	0.00909568	1	0.00914966	4	35										T	145140309	G	T	145140309	4	4	100	1	0	0	0	0	0	1	0	0	6587	943	33	3	1416	3	GPAA1	8	145140309	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	81151	145140309	1223713	405	30999										
GPAA1	8733	broad.mit.edu	37	chr8	145140621	145140621	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaccatggtgcccactgctGcgcttgccaagcctcatggg	11	16	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:145140621G>T	uc003zax.2	+	11	1707	c.1597G>T	c.(1597-1599)GCG>TCG	p.A533S		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	533	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCCACTGCTGCGCTTGCCAA	0.612													1	0	2.80697e-09	1	2.97985e-09	10	122										T	145140621	G	T	145140621	3	4	100	1	0	0	0	0	1	0	0	0	6587	1319	46	4	1639	4	GPAA1	8	145140621	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	312	145140621	1223401	406	31000										
ZNF7	7553	broad.mit.edu	37	chr8	146067042	146067042	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcggcctggattgtcagcctCttgaaagtcagggagagagt	15	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:146067042C>G	uc003zeg.3	+	5	687	c.550C>G	c.(550-552)CTT>GTT	p.L184V	ZNF7_uc010mge.2_Missense_Mutation_p.L195V|ZNF7_uc011lln.1_Missense_Mutation_p.L88V|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.L88V|COMMD5_uc003zel.1_RNA	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	184					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TTGTCAGCCTCTTGAAAGTCA	0.537													0	0	0	1	0	13	85										G	146067042	C	G	146067042	3	3	100	1	0	0	0	0	1	0	0	0	18099	913	32	1	564	1	ZNF7	8	146067042	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	926421	146067042	296980	407	31001										
MLANA	2315	broad.mit.edu	37	chr9	5908664	5908664	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaatgctccacctgcttatGagaaactctctgcagaacag	7	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:5908664G>C	uc003zjo.1	+	5	366	c.313G>C	c.(313-315)GAG>CAG	p.E105Q		NM_005511	NP_005502	Q16655	MAR1_HUMAN	melan-A	105	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane|melanosome|trans-Golgi network	protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(1;1.15e-06)|Lung(218;0.103)		ACCTGCTTATGAGAAACTCTC	0.433													0	0	0	1	0	26	28										C	5908664	G	C	5908664	3	2	100	1	0	0	0	0	1	0	0	0	9611	1291	45	1	327	1	MLANA	9	5908664	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		5908664	135304767	408	31002										
KIAA2026	158358	broad.mit.edu	37	chr9	5954074	5954074	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcctcttctttgtgattgctTttttagagacggattttttt	7	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:5954074T>G	uc003zjq.3	-	4	2450	c.2234A>C	c.(2233-2235)AAA>ACA	p.K745T	KIAA2026_uc010mht.2_5'UTR	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	745	Lys-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TGTGATTGCTTTTTTAGAGAC	0.308													0	0	0	1	0	2	1										G	5954074	T	G	5954074	3	3	100	1	0	0	0	0	1	0	0	0	8270	1841	64	5	4097	5	KIAA2026	9	5954074	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	45410	5954074	135259357	409	31003										
PSIP1	11168	broad.mit.edu	37	chr9	15490123	15490123	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctttggtcctaaaaaagcaCtaaaaaagaagtggggaaga	10	6	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:15490123C>A	uc003zlv.3	-	4	480	c.150_splice	c.e4-1	p.T50_splice	PSIP1_uc003zlw.3_Splice_Site_p.T50_splice|PSIP1_uc003zlz.3_Splice_Site_p.T50_splice|PSIP1_uc003zma.3_Splice_Site_p.T50_splice|PSIP1_uc003zly.2_Splice_Site_p.T50_splice	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TAAAAAAGCACTAAAAAAGAA	0.313													1	0	1.15088e-07	1	1.21289e-07	14	1										A	15490123	C	A	15490123	5	1	100	1	0	0	0	0	0	0	1	0	12663	579	20	4	1524	4	PSIP1	9	15490123	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9536049	15490123	125723308	410	31004										
CDKN2A	1029	broad.mit.edu	37	chr9	21974736	21974736	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagcgcccccgcctccagcaGcgcccgcacctcctctaccc	7	25	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:21974736G>C	uc003zpk.2	-	1	303	c.91C>G	c.(91-93)CTG>GTG	p.L31V	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.L31V|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	31	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.V28_E33del(2)|p.R29_A34del(2)|p.V28_V51del(1)|p.R29fs*9(1)|p.L31P(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCCTCCAGCAGCGCCCGCACC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	1	0	10	19										C	21974736	G	C	21974736	3	2	100	1	0	0	0	0	1	0	0	0	3161	962	34	4	592	4	CDKN2A	9	21974736	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	6484613	21974736	119238695	411	31005										
TAF1L	138474	broad.mit.edu	37	chr9	32630951	32630951	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgatgaaatggccaagaatCtggaactgccatcattttct	9	8	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:32630951C>G	uc003zrg.1	-	1	4717	c.4627G>C	c.(4627-4629)GAT>CAT	p.D1543H	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1543	Bromo 2.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGCCAAGAATCTGGAACTGCC	0.388													0	0	0	1	0	8	49										G	32630951	C	G	32630951	3	3	100	1	0	0	0	0	1	0	0	0	15520	913	32	1	857	1	TAF1L	9	32630951	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	10656215	32630951	108582480	412	31006										
PRSS3	5646	broad.mit.edu	37	chr9	33797839	33797839	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccatcagccgcatccaggtGagactgggagagcacaacat	11	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:33797839G>A	uc003ztj.3	+	3	384	c.384G>A	c.(382-384)GTG>GTA	p.V128V	uc003ztk.1_Intron|PRSS3_uc003zti.3_Silent_p.V85V|PRSS3_uc003ztl.3_Silent_p.V71V	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	128	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			GCATCCAGGTGAGACTGGGAG	0.587													0	0	0	1	0	4	48										A	33797839	G	A	33797839	2	1	100	1	0	0	0	0	0	0	0	1	12622	1277	45	1		1	PRSS3	9	33797839	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1166888	33797839	107415592	413	31007										
TLN1	7094	broad.mit.edu	37	chr9	35698825	35698825	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcccttgggccactagttCtctctgggcagccgacgcag	11	15	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:35698825C>G	uc003zxt.2	-	53	7459	c.7105G>C	c.(7105-7107)GAA>CAA	p.E2369Q		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2369	I/LWEQ.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCACTAGTTCTCTCTGGGCA	0.522													0	0	0	1	0	15	30										G	35698825	C	G	35698825	3	3	100	1	0	0	0	0	1	0	0	0	15944	922	32	1	540	1	TLN1	9	35698825	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1900986	35698825	105514606	414	31008										
SMC5	23137	broad.mit.edu	37	chr9	72892386	72892386	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atctttgccagtttctccctCaggtatgagagaaataaatg	8	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:72892386C>T	uc004ahr.2	+	4	658	c.541C>T	c.(541-543)CAG>TAG	p.Q181*		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	181					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						GTTTCTCCCTCAGGTATGAGA	0.338													0	0	0	1	0	16	19										T	72892386	C	T	72892386	4	4	100	1	0	0	0	0	0	1	0	0	14786	827	29	1	555	1	SMC5	9	72892386	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	37193561	72892386	68321045	415	31009										
FAM108B1	51104	broad.mit.edu	37	chr9	74489886	74489886	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttccgctttcatcacacatCagtgtgtaagttggatcagg	9	10	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:74489886C>T	uc004aim.1	-	2	713	c.111G>A	c.(109-111)CTG>CTA	p.L37L	FAM108B1_uc004ail.2_Silent_p.L37L	NM_001025780	NP_001020951	Q5VST6	F108B_HUMAN	family with sequence similarity 108, member B1	37						extracellular region	hydrolase activity				0						CATCACACATCAGTGTGTAAG	0.428													0	0	0	1	0	7	74										T	74489886	C	T	74489886	2	4	100	1	0	0	0	0	0	0	0	1	5392	813	29	1		1	FAM108B1	9	74489886	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1597500	74489886	66723545	416	31010										
ROR2	4920	broad.mit.edu	37	chr9	94487117	94487117	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgccgtgcgaacagtagctGaagatcatgctcaggggctg	14	10	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:94487117G>A	uc004arj.1	-	9	1858	c.1659C>T	c.(1657-1659)TTC>TTT	p.F553F	ROR2_uc004ari.1_Silent_p.F413F	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	553	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AACAGTAGCTGAAGATCATGC	0.637													0	0	0	1	0	31	4										A	94487117	G	A	94487117	2	1	100	1	0	0	0	0	0	0	0	1	13527	1281	45	1		1	ROR2	9	94487117	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	19997231	94487117	46726314	417	31011										
TEX10	54881	broad.mit.edu	37	chr9	103090142	103090142	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgtgctgcagcggtatgaatGatatcgataagctgtgtaga	13	6	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:103090142G>T	uc004bas.2	-	8	1943	c.1728C>A	c.(1726-1728)ATC>ATA	p.I576I	TEX10_uc011lvf.1_Silent_p.I415I|TEX10_uc011lvg.1_Silent_p.I579I	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	576						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CGGTATGAATGATATCGATAA	0.418													1	0	3.01185e-09	1	3.194e-09	26	8										T	103090142	G	T	103090142	2	4	100	1	0	0	0	0	0	0	0	1	15769	1280	45	3		3	TEX10	9	103090142	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	8603025	103090142	38123289	418	31012										
OR13C3	138803	broad.mit.edu	37	chr9	107298330	107298330	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtggctgaattcatttgcaaGatggtgtagaggatgaacat	13	4	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:107298330G>C	uc004bcb.1	-	1	765	c.765C>G	c.(763-765)ATC>ATG	p.I255M		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	255	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCATTTGCAAGATGGTGTAGA	0.413													0	0	0	1	0	57	9										C	107298330	G	C	107298330	3	2	100	1	0	0	0	0	1	0	0	0	10935	932	33	1	282	1	OR13C3	9	107298330	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4208188	107298330	33915101	419	31013										
OR13C3	138803	broad.mit.edu	37	chr9	107298688	107298688	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacattctgttgaccccattGcaaacccaaagaacatctgc	6	13	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:107298688G>A	uc004bcb.1	-	1	407	c.407C>T	c.(406-408)GCA>GTA	p.A136V		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	136	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TGACCCCATTGCAAACCCAAA	0.453													0	0	0	1	0	53	87										A	107298688	G	A	107298688	3	1	100	1	0	0	0	0	1	0	0	0	10935	1319	46	2	640	2	OR13C3	9	107298688	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	358	107298688	33914743	420	31014										
C9orf152	401546	broad.mit.edu	37	chr9	112963584	112963584	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttggaccaaacaatgcatctCcaggtgcgtgtgccatggag	12	10	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:112963584C>G	uc011lwk.1	-	2	918	c.364G>C	c.(364-366)GAG>CAG	p.E122Q		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	122											0						CAATGCATCTCCAGGTGCGTG	0.587													0	0	0	1	0	48	47										G	112963584	C	G	112963584	3	3	100	1	0	0	0	0	1	0	0	0	2463	864	30	1	359	1	C9orf152	9	112963584	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5664896	112963584	28249847	421	31015										
C9orf84	158401	broad.mit.edu	37	chr9	114510461	114510461	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tatccccgatatcctcaattCcatgcttgttagtaagatct	5	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:114510461C>T	uc004bfr.2	-	7	824	c.689G>A	c.(688-690)GGA>GAA	p.G230E	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfs.1_Missense_Mutation_p.G294E|C9orf84_uc004bfq.2_Missense_Mutation_p.G191E|C9orf84_uc010mug.2_Missense_Mutation_p.G176E	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	230										ovary(2)	2						ATCCTCAATTCCATGCTTGTT	0.353													0	0	0	1	0	19	36										T	114510461	C	T	114510461	3	4	100	1	0	0	0	0	1	0	0	0	2500	855	30	1	3725	1	C9orf84	9	114510461	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1546877	114510461	26702970	422	31016										
ODF2	4957	broad.mit.edu	37	chr9	131256844	131256844	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagcagctccctgacatccTgaagatcacggaggcgaagc	12	13	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:131256844T>A	uc011mbd.1	+	17	2119	c.1808T>A	c.(1807-1809)CTG>CAG	p.L603Q	ODF2_uc011maz.1_Missense_Mutation_p.L603Q|ODF2_uc011mbc.1_Missense_Mutation_p.L522Q|ODF2_uc004bva.2_Missense_Mutation_p.L556Q|ODF2_uc004bvb.2_Missense_Mutation_p.L579Q|ODF2_uc011mbe.1_Missense_Mutation_p.L598Q|ODF2_uc004bvc.2_Missense_Mutation_p.L579Q|ODF2_uc011mbf.1_Missense_Mutation_p.L584Q|ODF2_uc004bvd.3_Missense_Mutation_p.L603Q|ODF2_uc004bve.2_Missense_Mutation_p.L584Q|ODF2_uc004bvh.2_5'Flank	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	603	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CCTGACATCCTGAAGATCACG	0.562													0	0	0	1	0	10	21										A	131256844	T	A	131256844	3	1	100	1	0	0	0	0	1	0	0	0	10827	1580	55	5	1925	5	ODF2	9	131256844	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	16746383	131256844	9956587	423	31017										
SPTAN1	6709	broad.mit.edu	37	chr9	131341958	131341958	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagcttcaaatctgcagatGaatctggacaggcactgctt	9	10	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:131341958G>A	uc004bvl.3	+	10	1377	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K	SPTAN1_uc011mbg.1_Missense_Mutation_p.E422K|SPTAN1_uc011mbh.1_Missense_Mutation_p.E434K|SPTAN1_uc004bvm.3_Missense_Mutation_p.E422K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E422K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	422	Spectrin 5.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATCTGCAGATGAATCTGGACA	0.428													0	0	0	1	0	34	2										A	131341958	G	A	131341958	3	1	100	1	0	0	0	0	1	0	0	0	15116	1291	45	1	1298	1	SPTAN1	9	131341958	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	85114	131341958	9871473	424	31018										
FCN1	2219	broad.mit.edu	37	chr9	137803022	137803022	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagtaccagcttgtacttCtctgcctcgtcagccacctt	6	17	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:137803022C>G	uc004cfi.2	-	8	782	c.690G>C	c.(688-690)GAG>GAC	p.E230D		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	230	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GCTTGTACTTCTCTGCCTCGT	0.552													0	0	0	1	0	72	173										G	137803022	C	G	137803022	3	3	100	1	0	0	0	0	1	0	0	0	5791	912	32	1	298	1	FCN1	9	137803022	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6461064	137803022	3410409	425	31019										
KIAA0649	9858	broad.mit.edu	37	chr9	138378236	138378236	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgccgaccacagccaggggaGagctgagcccggccatgaga	15	13	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:138378236G>A	uc004cfr.1	+	4	2429	c.1880G>A	c.(1879-1881)AGA>AAA	p.R627K		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	627						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		AGCCAGGGGAGAGCTGAGCCC	0.662													0	0	0	1	0	4	41										A	138378236	G	A	138378236	3	1	100	1	0	0	0	0	1	0	0	0	8187	942	33	1	1882	1	KIAA0649	9	138378236	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	575214	138378236	2835195	426	31020										
SNAPC4	6621	broad.mit.edu	37	chr9	139273711	139273711	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccctttgtggctggcactCtttgaggcttcttgagccgg	12	12	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:139273711C>G	uc004chh.2	-	21	2577	c.2568G>C	c.(2566-2568)AAG>AAC	p.K856N		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	856					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGCTGGCACTCTTTGAGGCTT	0.662													0	0	0	1	0	14	4										G	139273711	C	G	139273711	3	3	100	1	0	0	0	0	1	0	0	0	14837	912	32	1	1849	1	SNAPC4	9	139273711	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	895475	139273711	1939720	427	31021										
NOTCH1	4851	broad.mit.edu	37	chr9	139405623	139405623	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccttgccagcccgtggggcaGacacaggagaagctctcata	12	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:139405623G>C	uc004chz.2	-	16	2568	c.2568C>G	c.(2566-2568)GTC>GTG	p.V856V	NOTCH1_uc004cia.1_Silent_p.V86V	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	856	Extracellular (Potential).|EGF-like 22.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGTGGGGCAGACACAGGAGA	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	1	0	17	69										C	139405623	G	C	139405623	2	2	100	1	0	0	0	0	0	0	0	1	10547	929	33	1		1	NOTCH1	9	139405623	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	131912	139405623	1807808	428	31022										
COBRA1	25920	broad.mit.edu	37	chr9	140166654	140166654	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcagcctcttcgatggcttCttcctcaccgcctctccaag	7	17	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:140166654C>T	uc004cmm.3	+	11	1670	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	489					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		TCGATGGCTTCTTCCTCACCG	0.617													0	0	0	1	0	58	26										T	140166654	C	T	140166654	2	4	100	1	0	0	0	0	0	0	0	1	3655	912	32	1		1	COBRA1	9	140166654	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	761031	140166654	1046777	429	31023										
EHMT1	79813	broad.mit.edu	37	chr9	140657159	140657159	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtccagatgtgctggagacaGacggcctccaggaagtgcct	14	11	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:140657159G>C	uc011mfc.1	+	10	1571	c.1534G>C	c.(1534-1536)GAC>CAC	p.D512H	EHMT1_uc004coa.2_Missense_Mutation_p.D512H|EHMT1_uc004cob.1_Missense_Mutation_p.D481H|FLJ40292_uc010nco.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	512					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCTGGAGACAGACGGCCTCCA	0.537													0	0	0	1	0	6	31										C	140657159	G	C	140657159	3	2	100	1	0	0	0	0	1	0	0	0	4983	942	33	1	1572	1	EHMT1	9	140657159	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	490505	140657159	556272	430	31024										
ITIH2	3698	broad.mit.edu	37	chr10	7786827	7786827	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agatgtccttttctgttttaCttcatcgtgtttggaagaag	9	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:7786827C>G	uc001ijs.2	+	19	2644	c.2482C>G	c.(2482-2484)CTT>GTT	p.L828V		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	828					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TTCTGTTTTACTTCATCGTGT	0.423													0	0	0	1	0	12	86										G	7786827	C	G	7786827	3	3	100	1	0	0	0	0	1	0	0	0	7904	565	20	4	2556	4	ITIH2	10	7786827	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		7786827	127747920	431	31025										
CELF2	10659	broad.mit.edu	37	chr10	11047353	11047353	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gactatcagtatagaagcatGcgctgtcccaaatccgctgt	9	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:11047353G>T	uc001iki.3	+	1	95	c.3G>T	c.(1-3)ATG>ATT	p.M1I	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Missense_Mutation_p.M1I	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	1	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						ATAGAAGCATGCGCTGTCCCA	0.393													1	0	1.15505e-17	1	1.27961e-17	38	216										T	11047353	G	T	11047353	3	4	100	1	0	0	0	0	1	0	0	0	3216	1319	46	4	5	4	CELF2	10	11047353	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3260526	11047353	124487394	432	31026										
FRMD4A	55691	broad.mit.edu	37	chr10	13698952	13698952	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccgccgcgccagctctccttGaacaggccgcccgccgtgta	11	19	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:13698952G>C	uc001ims.2	-	22	2989	c.2637C>G	c.(2635-2637)TTC>TTG	p.F879L	FRMD4A_uc009xjf.1_Missense_Mutation_p.F879L	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	879						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						AGCTCTCCTTGAACAGGCCGC	0.716													0	0	0	1	0	8	14										C	13698952	G	C	13698952	3	2	100	1	0	0	0	0	1	0	0	0	6051	1281	45	1	494	1	FRMD4A	10	13698952	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2651599	13698952	121835795	433	31027										
HSPA14	51182	broad.mit.edu	37	chr10	14909867	14909867	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccttgaactctatgagtctGatgggaagaactctgccaaa	10	9	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:14909867G>C	uc001inf.2	+	12	1480	c.1339G>C	c.(1339-1341)GAT>CAT	p.D447H		NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	447					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						CTATGAGTCTGATGGGAAGAA	0.433													0	0	0	1	0	22	103										C	14909867	G	C	14909867	3	2	100	1	0	0	0	0	1	0	0	0	7407	1290	45	1	1385	1	HSPA14	10	14909867	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1210915	14909867	120624880	434	31028										
DCLRE1C	64421	broad.mit.edu	37	chr10	14995952	14995952	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggccctcaggttctccctatCgaagcggtctatggagatag	12	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:14995952C>G	uc001inn.2	-	1	143	c.58G>C	c.(58-60)GAT>CAT	p.D20H	DCLRE1C_uc010qbx.1_Missense_Mutation_p.D20H|DCLRE1C_uc001inl.2_5'UTR|DCLRE1C_uc009xji.2_5'UTR|DCLRE1C_uc001inm.2_5'UTR|DCLRE1C_uc001ino.2_5'UTR|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_5'UTR|DCLRE1C_uc001inq.2_5'UTR|DCLRE1C_uc001inr.2_5'UTR	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	20					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						TTCTCCCTATCGAAGCGGTCT	0.647								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					0	0	0	1	0	22	95										G	14995952	C	G	14995952	3	3	100	1	0	0	0	0	1	0	0	0	4296	884	31	1	2076	1	DCLRE1C	10	14995952	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	86085	14995952	120538795	435	31029										
NMT2	9397	broad.mit.edu	37	chr10	15154865	15154865	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgtgtggatgttgtagaatGagtaggcggctttgaggctc	16	5	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:15154865G>C	uc001inz.1	-	10	1352	c.1268C>G	c.(1267-1269)TCA>TGA	p.S423*	NMT2_uc001ioa.1_Nonsense_Mutation_p.S410*|NMT2_uc009xjo.1_Nonsense_Mutation_p.S423*|NMT2_uc010qbz.1_Nonsense_Mutation_p.S235*	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	423					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						GTTGTAGAATGAGTAGGCGGC	0.552													0	0	0	1	0	25	137										C	15154865	G	C	15154865	4	2	100	1	0	0	0	0	0	1	0	0	10504	1294	45	1	240	1	NMT2	10	15154865	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	158913	15154865	120379882	436	31030										
KIAA1217	56243	broad.mit.edu	37	chr10	24669900	24669900	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attctttggaagccatgtctGagggggatgctccaacccct	11	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:24669900G>C	uc001iru.3	+	3	860	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	KIAA1217_uc001irs.2_Missense_Mutation_p.E73Q|KIAA1217_uc001irt.3_Missense_Mutation_p.E153Q|KIAA1217_uc010qcy.1_Missense_Mutation_p.E153Q|KIAA1217_uc010qcz.1_Missense_Mutation_p.E153Q|KIAA1217_uc001irv.1_Missense_Mutation_p.E3Q|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	153					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AGCCATGTCTGAGGGGGATGC	0.552													0	0	0	1	0	31	29										C	24669900	G	C	24669900	3	2	100	1	0	0	0	0	1	0	0	0	8216	1291	45	1	467	1	KIAA1217	10	24669900	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9515035	24669900	110864847	437	31031										
MRPS16	51021	broad.mit.edu	37	chr10	75011600	75011600	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgtctaggttgagggcaacGagtttttctccatgactgtt	11	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:75011600G>C	uc001jts.1	-	2	406	c.195C>G	c.(193-195)CTC>CTG	p.L65L	DNAJC9_uc010qkg.1_5'Flank|MRPS16_uc010qkh.1_RNA|MRPS16_uc001jtt.1_RNA|uc001jtu.1_5'Flank	NM_016065	NP_057149	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16 precursor	65					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0	Prostate(51;0.0119)					TGAGGGCAACGAGTTTTTCTC	0.537													0	0	0	1	0	57	26										C	75011600	G	C	75011600	2	2	100	1	0	0	0	0	0	0	0	1	9826	1045	37	1		1	MRPS16	10	75011600	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	50341700	75011600	60523147	438	31032										
PTEN	5728	broad.mit.edu	37	chr10	89725134	89725134	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caccagatgttagtgacaatGaacctgatcattatagatat	7	7	1	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:89725134G>A	uc001kfb.2	+	10	2148	c.1117G>A	c.(1117-1119)GAA>AAA	p.E373K		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	373					activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y27fs*1(2)|p.N212fs*1(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TAGTGACAATGAACCTGATCA	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			0	0	0	1	0	10	17										A	89725134	G	A	89725134	3	1	100	1	0	0	0	0	1	0	0	0	12738	1291	45	1	1151	1	PTEN	10	89725134	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	14713534	89725134	45809613	439	31033										
BTAF1	9044	broad.mit.edu	37	chr10	93699793	93699793	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctatagtgaaaaatgtacctGagtggaatccagtgccgaga	11	7	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:93699793G>C	uc001khr.2	+	3	321	c.223G>C	c.(223-225)GAG>CAG	p.E75Q	BTAF1_uc009xua.1_RNA	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	75					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				AAATGTACCTGAGTGGAATCC	0.353													0	0	0	1	0	8	14										C	93699793	G	C	93699793	3	2	100	1	0	0	0	0	1	0	0	0	1536	1291	45	1	233	1	BTAF1	10	93699793	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3974659	93699793	41834954	440	31034										
PDE6C	5146	broad.mit.edu	37	chr10	95400704	95400704	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gattaaagaagtactacacaGatctcgaagcctttgccatg	8	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:95400704G>T	uc001kiu.3	+	14	1903	c.1765G>T	c.(1765-1767)GAT>TAT	p.D589Y		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	589					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GTACTACACAGATCTCGAAGC	0.363													1	0	0.00244969	1	0.00248141	15	29										T	95400704	G	T	95400704	3	4	100	1	0	0	0	0	1	0	0	0	11647	942	33	3	1819	3	PDE6C	10	95400704	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1700911	95400704	40134043	441	31035										
HELLS	3070	broad.mit.edu	37	chr10	96317928	96317928	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagaaaaattggagagaaaAaaggagtctttaaaagttaa	9	1	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:96317928A>T	uc001kjt.2	+	4	414	c.309A>T	c.(307-309)AAA>AAT	p.K103N	HELLS_uc001kjs.2_Missense_Mutation_p.K87N|HELLS_uc009xul.2_Missense_Mutation_p.K103N|HELLS_uc009xum.2_Missense_Mutation_p.K103N|HELLS_uc009xun.2_5'UTR|HELLS_uc009xuo.2_Missense_Mutation_p.K103N|HELLS_uc001kju.2_5'UTR|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_5'UTR|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	103	Potential.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		TGGAGAGAAAAAAGGAGTCTT	0.269													0	0	0	1	0	20	23										T	96317928	A	T	96317928	3	4	100	1	0	0	0	0	1	0	0	0	7046	11	1	5	323	5	HELLS	10	96317928	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	917224	96317928	39216819	442	31036										
PIK3AP1	118788	broad.mit.edu	37	chr10	98383279	98383279	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aattcccaggccgctcttgaCttttttctgcaaaaactatg	6	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:98383279C>A	uc001kmq.2	-	11	1813	c.1685G>T	c.(1684-1686)AGT>ATT	p.S562I	PIK3AP1_uc001kmo.2_Missense_Mutation_p.S161I|PIK3AP1_uc001kmp.2_Missense_Mutation_p.S384I	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	562						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CCGCTCTTGACTTTTTTCTGC	0.343													1	0	1.00798e-23	1	1.13023e-23	58	81										A	98383279	C	A	98383279	3	1	100	1	0	0	0	0	1	0	0	0	11908	565	20	4	760	4	PIK3AP1	10	98383279	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2065351	98383279	37151468	443	31037										
FAM178A	55719	broad.mit.edu	37	chr10	102672946	102672946	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgtcgcccccgcgctgccatCtgagacccggtagtaccgcc	11	19	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:102672946C>G	uc001krt.3	+	1	621	c.79C>G	c.(79-81)CTG>GTG	p.L27V	FAM178A_uc001krq.3_RNA|FAM178A_uc001krr.1_Missense_Mutation_p.L27V|FAM178A_uc001krs.2_Missense_Mutation_p.L27V	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	27											0						GCGCTGCCATCTGAGACCCGG	0.697													0	0	0	1	0	5	2										G	102672946	C	G	102672946	3	3	100	1	0	0	0	0	1	0	0	0	5503	912	32	1	81	1	FAM178A	10	102672946	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4289667	102672946	32861801	444	31038										
TACC2	10579	broad.mit.edu	37	chr10	124008642	124008642	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagcagaggtaccaggccctGaaggtgcacgcggaggagaa	17	9	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:124008642G>A	uc001lfv.2	+	21	8991	c.8631G>A	c.(8629-8631)CTG>CTA	p.L2877L	TACC2_uc001lfw.2_Silent_p.L1023L|TACC2_uc009xzx.2_Silent_p.L2755L|TACC2_uc010qtv.1_Silent_p.L2804L|TACC2_uc001lfx.2_Silent_p.L504L|TACC2_uc001lfy.2_Silent_p.L500L|TACC2_uc001lfz.2_Silent_p.L955L|TACC2_uc001lga.2_Silent_p.L925L|TACC2_uc009xzy.2_Silent_p.L937L|TACC2_uc001lgb.2_Silent_p.L835L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2877	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACCAGGCCCTGAAGGTGCACG	0.602													0	0	0	1	0	3	5										A	124008642	G	A	124008642	2	1	100	1	0	0	0	0	0	0	0	1	15499	1277	45	1		1	TACC2	10	124008642	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	21335696	124008642	11526105	445	31039										
PLEKHA1	59338	broad.mit.edu	37	chr10	124175485	124175485	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctcaagatagtgcggttatCaaagctggatattgtgtaaa	10	6	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:124175485C>G	uc001lge.1	+	7	702	c.579C>G	c.(577-579)ATC>ATG	p.I193M	PLEKHA1_uc001lgf.1_Missense_Mutation_p.I193M|PLEKHA1_uc001lgg.1_Missense_Mutation_p.I193M|PLEKHA1_uc001lgh.2_Missense_Mutation_p.I193M	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	193	PH 2.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGCGGTTATCAAAGCTGGAT	0.348													0	0	0	1	0	16	1										G	124175485	C	G	124175485	3	3	100	1	0	0	0	0	1	0	0	0	12055	816	29	1	601	1	PLEKHA1	10	124175485	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	166843	124175485	11359262	446	31040										
MUC5B	727897	broad.mit.edu	37	chr11	1278842	1278866	+	Frame_Shift_Del	DEL	GTGACGCCCAGGGTCAGCCCCCGCC	GTGACGCCCAGGGTCAGCCCCCGCC	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagtgcaagcccctgccctGtgacgcccagggtcagcccc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:1278842_1278866delGTGACGCCCAGGGTCAGCCCCCGCC	uc009ycr.1	+	63	17489_17513	c.17363_17387delGTGACGCCCAGGGTCAGCCCCCGCC	c.(17362-17388)TGTGACGCCCAGGGTCAGCCCCCGCCGfs	p.C5788fs	MUC5B_uc001ltb.2_Frame_Shift_Del_p.C5454fs	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5451_5459	VWFC 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCCTGCCCTGTGACGCCCAGGGTCAGCCCCCGCCGTGCAACCGT	0.684																		7	9	---	---								-	1278866	GTGACGCCCAGGGTCAGCCCCCGCC	-	1278842	7	5	100	1	0	1	0	1	0	0	0	0	9979	1377	48	0	16523	0	MUC5B	11	1278842	Frame_Shift_Del	DEL	GTGACGCCCAGGGTCAGCCCCCGCC	TCGA-G2-A3VY-01A-11D-A22Z-08		1278842	133727674	447	31041										
ART1	417	broad.mit.edu	37	chr11	3680949	3680949	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctcccggatctcaaccacaCggagttccaggccaaccagg	9	16	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:3680949C>A	uc001lye.1	+	3	301	c.200C>A	c.(199-201)ACG>AAG	p.T67K	ART1_uc009yeb.1_Missense_Mutation_p.T67K	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	67					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CTCAACCACACGGAGTTCCAG	0.602													1	0	0.000274275	1	0.000279497	8	4										A	3680949	C	A	3680949	3	1	100	1	0	0	0	0	1	0	0	0	997	536	19	4	206	4	ART1	11	3680949	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2402107	3680949	131325567	448	31042										
OR52B4	143496	broad.mit.edu	37	chr11	4389102	4389102	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacacaaattttcttgatcaGagcatttgtaagaatggtgg	9	6	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:4389102G>C	uc010qye.1	-	1	424	c.424C>G	c.(424-426)CTG>GTG	p.L142V		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCTTGATCAGAGCATTTGTA	0.388													0	0	0	1	0	14	31										C	4389102	G	C	4389102	3	2	100	1	0	0	0	0	1	0	0	0	11112	933	33	1	524	1	OR52B4	11	4389102	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	708153	4389102	130617414	449	31043										
TUB	7275	broad.mit.edu	37	chr11	8120357	8120357	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgacaatggagtcaaccctCagaaggcctcatcctccact	7	14	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:8120357C>T	uc001mga.2	+	9	1200	c.1051C>T	c.(1051-1053)CAG>TAG	p.Q351*	TUB_uc010rbk.1_Nonsense_Mutation_p.Q357*|TUB_uc001mfy.2_Nonsense_Mutation_p.Q406*	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	351					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGTCAACCCTCAGAAGGCCTC	0.507											OREG0020732	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	17	66										T	8120357	C	T	8120357	4	4	100	1	0	0	0	0	0	1	0	0	16739	827	29	1	1296	1	TUB	11	8120357	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3731255	8120357	126886159	450	31044										
IPO7	10527	broad.mit.edu	37	chr11	9450610	9450610	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcactatttttgtgaagtGaagttcaaaagtgatcagaa	8	5	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:9450610G>A	uc001mho.2	+	14	1600	c.1458G>A	c.(1456-1458)GTG>GTA	p.V486V		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	486					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTTGTGAAGTGAAGTTCAAAA	0.388													0	0	0	1	0	27	22										A	9450610	G	A	9450610	2	1	100	1	0	0	0	0	0	0	0	1	7797	1277	45	1		1	IPO7	11	9450610	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1330253	9450610	125555906	451	31045										
UEVLD	55293	broad.mit.edu	37	chr11	18555896	18555896	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctttgctaaagctgatacaGaatgcactttcttcttattg	6	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:18555896G>A	uc001mot.2	-	11	1309	c.1229C>T	c.(1228-1230)TCT>TTT	p.S410F	UEVLD_uc001mou.2_Intron|UEVLD_uc010rde.1_Missense_Mutation_p.S280F|UEVLD_uc010rdf.1_Missense_Mutation_p.S388F|UEVLD_uc010rdg.1_Missense_Mutation_p.S280F|UEVLD_uc001mov.2_Intron	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	410					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						AGCTGATACAGAATGCACTTT	0.299													0	0	0	1	0	4	44										A	18555896	G	A	18555896	3	1	100	1	0	0	0	0	1	0	0	0	16930	942	33	1	194	1	UEVLD	11	18555896	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9105286	18555896	116450620	452	31046										
SPTY2D1	144108	broad.mit.edu	37	chr11	18637593	18637593	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttgctttcttgtcatgtttGagctcaattcgctttttcac	6	10	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:18637593G>C	uc001moy.2	-	3	444	c.228C>G	c.(226-228)CTC>CTG	p.L76L	SPTY2D1_uc010rdi.1_Silent_p.L76L	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	76	Potential.									breast(1)	1						TGTCATGTTTGAGCTCAATTC	0.388													0	0	0	1	0	33	38										C	18637593	G	C	18637593	2	2	100	1	0	0	0	0	0	0	0	1	15125	1277	45	1		1	SPTY2D1	11	18637593	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	81697	18637593	116368923	453	31047										
LUZP2	338645	broad.mit.edu	37	chr11	24998163	24998163	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagcttactgatctggaacaAaaattagctgtagccaaaaa	7	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:24998163A>T	uc001mqs.2	+	8	783	c.549A>T	c.(547-549)CAA>CAT	p.Q183H	LUZP2_uc009yif.2_Missense_Mutation_p.Q97H|LUZP2_uc009yig.2_Missense_Mutation_p.Q141H	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	183	Potential.|Leucine-zipper.					extracellular region				ovary(1)|skin(1)	2						ATCTGGAACAAAAATTAGCTG	0.343													0	0	0	1	0	9	35										T	24998163	A	T	24998163	3	4	100	1	0	0	0	0	1	0	0	0	9087	11	1	5	579	5	LUZP2	11	24998163	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	6360570	24998163	110008353	454	31048										
CCDC73	493860	broad.mit.edu	37	chr11	32632777	32632777	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggatggatactccagttattCaaagtgtcagcaactctgtt	9	8	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:32632777C>G	uc001mtv.2	-	17	2975	c.2931G>C	c.(2929-2931)TTG>TTC	p.L977F		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	977										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TCCAGTTATTCAAAGTGTCAG	0.393													0	0	0	1	0	26	78										G	32632777	C	G	32632777	3	3	100	1	0	0	0	0	1	0	0	0	2846	825	29	1	316	1	CCDC73	11	32632777	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	7634614	32632777	102373739	455	31049										
ALX4	60529	broad.mit.edu	37	chr11	44331236	44331236	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggggcgtcttgcaggcgcctCgctgcaagtaaagatgcggt	16	10	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:44331236C>T	uc001myb.2	-	1	481	c.377G>A	c.(376-378)CGA>CAA	p.R126Q		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	126					hair follicle development						0						GCAGGCGCCTCGCTGCAAGTA	0.473													0	0	0	1	0	4	0										T	44331236	C	T	44331236	3	4	100	1	0	0	0	0	1	0	0	0	558	884	31	1	874	1	ALX4	11	44331236	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11698459	44331236	90675280	456	31050										
PRDM11	56981	broad.mit.edu	37	chr11	45246160	45246160	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaaggagccaggccaattgGaggatgaagaagaggagcct	15	8	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:45246160G>C	uc001myo.2	+	8	1486	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	413										upper_aerodigestive_tract(1)	1						AGGCCAATTGGAGGATGAAGA	0.577													0	0	0	1	0	38	63										C	45246160	G	C	45246160	3	2	100	1	0	0	0	0	1	0	0	0	12452	1175	41	1	1263	1	PRDM11	11	45246160	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	914924	45246160	89760356	457	31051										
OR5D13	390142	broad.mit.edu	37	chr11	55540964	55540964	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acacccacttttattctcttGggtttttcagaatacccaga	5	11	2	2	rs117263837	byFrequency	TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:55540964G>C	uc010ril.1	+	1	51	c.51G>C	c.(49-51)TTG>TTC	p.L17F		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TTATTCTCTTGGGTTTTTCAG	0.383													0	0	0	1	0	37	244										C	55540964	G	C	55540964	3	2	100	1	0	0	0	0	1	0	0	0	11154	1339	47	4	53	4	OR5D13	11	55540964	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	10294804	55540964	79465552	458	31052										
OR5M10	390167	broad.mit.edu	37	chr11	56344278	56344278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caattttacaaaaggattttCccctaatcatttgttgtatg	5	7	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:56344278C>T	uc001niz.1	-	1	920	c.920G>A	c.(919-921)GGA>GAA	p.G307E		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGGATTTTCCCCTAATCAT	0.373													0	0	0	1	0	75	251										T	56344278	C	T	56344278	3	4	100	1	0	0	0	0	1	0	0	0	11173	855	30	1	31	1	OR5M10	11	56344278	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	803314	56344278	78662238	459	31053										
OSBP	5007	broad.mit.edu	37	chr11	59368846	59368846	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgctcatgtcccctttgccaGagcagcactgatctacaaga	8	14	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:59368846G>A	uc001noc.1	-	5	1514	c.1034C>T	c.(1033-1035)TCT>TTT	p.S345F	OSBP_uc009ymr.1_5'Flank	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	345					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCCTTTGCCAGAGCAGCACTG	0.393													0	0	0	1	0	13	43										A	59368846	G	A	59368846	3	1	100	1	0	0	0	0	1	0	0	0	11273	942	33	1	1429	1	OSBP	11	59368846	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3024568	59368846	75637670	460	31054										
DAGLA	747	broad.mit.edu	37	chr11	61488339	61488339	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggagccccgtgactccatgcAgtacgtgctctacgtgcgcc	12	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:61488339A>C	uc001nsa.2	+	3	395	c.284A>C	c.(283-285)CAG>CCG	p.Q95P		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	95	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GACTCCATGCAGTACGTGCTC	0.542													0	0	0	1	0	20	44										C	61488339	A	C	61488339	3	2	100	1	0	0	0	0	1	0	0	0	4226	188	7	5	290	5	DAGLA	11	61488339	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	2119493	61488339	73518177	461	31055										
AHNAK	79026	broad.mit.edu	37	chr11	62289440	62289440	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgccttccactttgggcagaGaaacgtccacgtcgcccttc	9	16	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62289440G>A	uc001ntl.2	-	5	12749	c.12449C>T	c.(12448-12450)TCT>TTT	p.S4150F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4150					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTTGGGCAGAGAAACGTCCAC	0.522													0	0	0	1	0	41	92										A	62289440	G	A	62289440	3	1	100	1	0	0	0	0	1	0	0	0	414	942	33	1	5343	1	AHNAK	11	62289440	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	801101	62289440	72717076	462	31056										
TUT1	64852	broad.mit.edu	37	chr11	62348892	62348892	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgaagacctcctgcatcagGgccaccactaggctgcgaag	12	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62348892G>C	uc001nto.2	-	3	707	c.669C>G	c.(667-669)GCC>GCG	p.A223A		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	185					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						CCTGCATCAGGGCCACCACTA	0.587													0	0	0	1	0	6	23										C	62348892	G	C	62348892	2	2	100	1	0	0	0	0	0	0	0	1	16777	1219	43	4		4	TUT1	11	62348892	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	59452	62348892	72657624	463	31057										
NXF1	10482	broad.mit.edu	37	chr11	62561884	62561884	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcagaactggcattccgcaCaaatagctcatcatttacaa	5	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62561884C>G	uc001nvf.1	-	19	1742	c.1606G>C	c.(1606-1608)GTG>CTG	p.V536L	TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Missense_Mutation_p.V579L	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	536	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						GCATTCCGCACAAATAGCTCA	0.493													0	0	0	1	0	8	43										G	62561884	C	G	62561884	3	3	100	1	0	0	0	0	1	0	0	0	10782	478	17	4	265	4	NXF1	11	62561884	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	212992	62561884	72444632	464	31058										
SLC22A8	9376	broad.mit.edu	37	chr11	62760912	62760912	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaccagttttccaggtcttCgatagtctctggcaagggct	11	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62760912C>T	uc001nwo.2	-	10	1649	c.1513G>A	c.(1513-1515)GAA>AAA	p.E505K	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Missense_Mutation_p.E505K|SLC22A8_uc009yom.2_Missense_Mutation_p.E382K|SLC22A8_uc010rmm.1_Missense_Mutation_p.E414K|SLC22A8_uc009yon.2_Missense_Mutation_p.E505K	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	505	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						TCCAGGTCTTCGATAGTCTCT	0.597													0	0	0	1	0	24	57										T	62760912	C	T	62760912	3	4	100	1	0	0	0	0	1	0	0	0	14460	893	31	1	123	1	SLC22A8	11	62760912	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	199028	62760912	72245604	465	31059										
PLCB3	5331	broad.mit.edu	37	chr11	64026396	64026396	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atggctgagtactgccgctcCatctttggagacgcgctact	11	12	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64026396C>G	uc001nzb.2	+	12	1293	c.1293C>G	c.(1291-1293)TCC>TCG	p.S431S	PLCB3_uc009ypg.1_Silent_p.S431S|PLCB3_uc009yph.1_Silent_p.S364S|PLCB3_uc009ypi.2_Silent_p.S431S	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	431	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						ACTGCCGCTCCATCTTTGGAG	0.637													0	0	0	1	0	9	21										G	64026396	C	G	64026396	2	3	100	1	0	0	0	0	0	0	0	1	12029	581	21	4		4	PLCB3	11	64026396	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1265484	64026396	70980120	466	31060										
NRXN2	9379	broad.mit.edu	37	chr11	64457929	64457929	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctctcccggcccccccctcGgagaacagtaaggaccctac	8	20	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64457929G>A	uc001oar.2	-	6	1237	c.798C>T	c.(796-798)TCC>TCT	p.S266S	NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_5'UTR	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCCCCCCCTCGGAGAACAGTA	0.647													0	0	0	1	0	14	9										A	64457929	G	A	64457929	2	1	100	1	0	0	0	0	0	0	0	1	10666	1103	39	2		2	NRXN2	11	64457929	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	431533	64457929	70548587	467	31061										
ATG2A	23130	broad.mit.edu	37	chr11	64673042	64673042	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcggcctgcatacctgagcaGgaaggtggaggtgtccatga	16	9	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64673042G>T	uc001obx.2	-	24	3572	c.3457C>A	c.(3457-3459)CTG>ATG	p.L1153M	ATG2A_uc001obw.2_5'Flank	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1153							protein binding			ovary(1)|central_nervous_system(1)	2						TACCTGAGCAGGAAGGTGGAG	0.617													1	0	5.4927e-09	1	5.81883e-09	8	3										T	64673042	G	T	64673042	3	4	100	1	0	0	0	0	1	0	0	0	1093	991	35	4	2431	4	ATG2A	11	64673042	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	215113	64673042	70333474	468	31062										
C11orf2	738	broad.mit.edu	37	chr11	64876860	64876860	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccctggggagaaggggggtGccacaccacctgccctgctc	15	15	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64876860G>T	uc001ocr.1	+	6	1592	c.1552G>T	c.(1552-1554)GCC>TCC	p.A518S	TM7SF2_uc001oct.2_5'Flank|TM7SF2_uc010rny.1_5'Flank|TM7SF2_uc001ocu.2_5'Flank|TM7SF2_uc001ocv.2_5'Flank|C11orf2_uc001ocs.1_Missense_Mutation_p.A394S	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	518					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						GAAGGGGGGTGCCACACCACC	0.617													1	0	3.59834e-05	1	3.70396e-05	6	36										T	64876860	G	T	64876860	3	4	100	1	0	0	0	0	1	0	0	0	1633	1319	46	4	1574	4	C11orf2	11	64876860	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	203818	64876860	70129656	469	31063										
SYVN1	84447	broad.mit.edu	37	chr11	64895935	64895935	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggctctccatcctcaggcatCtcctctgtgcccactgactc	7	18	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64895935C>T	uc001odb.2	-	16	1867	c.1773G>A	c.(1771-1773)GAG>GAA	p.E591E	SYVN1_uc001odc.2_Silent_p.E590E|SYVN1_uc009yqc.2_Silent_p.E539E	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	591	Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						CCTCAGGCATCTCCTCTGTGC	0.642													0	0	0	1	0	16	29										T	64895935	C	T	64895935	2	4	100	1	0	0	0	0	0	0	0	1	15484	912	32	1		1	SYVN1	11	64895935	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	19075	64895935	70110581	470	31064										
KCNK7	10089	broad.mit.edu	37	chr11	65360568	65360568	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	taggatgccaccttggtcctCagcagtcacaggaccactgg	11	13	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:65360568C>T	uc001oes.2	-	3	1056	c.832G>A	c.(832-834)GAG>AAG	p.E278K	KCNK7_uc001oeq.2_3'UTR|KCNK7_uc001oer.2_3'UTR|KCNK7_uc001oeu.2_3'UTR	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	278	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						CCTTGGTCCTCAGCAGTCACA	0.627													0	0	0	1	0	4	16										T	65360568	C	T	65360568	3	4	100	1	0	0	0	0	1	0	0	0	8071	835	29	1	95	1	KCNK7	11	65360568	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	464633	65360568	69645948	471	31065										
SPTBN2	6712	broad.mit.edu	37	chr11	66458983	66458983	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggtcagcccaggcctcgttGagactgtccttccactcggc	11	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:66458983G>C	uc001ojd.2	-	26	5409	c.5337C>G	c.(5335-5337)CTC>CTG	p.L1779L		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1779	Spectrin 14.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGGCCTCGTTGAGACTGTCCT	0.672													0	0	0	1	0	8	29										C	66458983	G	C	66458983	2	2	100	1	0	0	0	0	0	0	0	1	15119	1277	45	1		1	SPTBN2	11	66458983	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1098415	66458983	68547533	472	31066										
SPTBN2	6712	broad.mit.edu	37	chr11	66460498	66460498	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggccgccagctggtggatgGtctgcgcgtagtcggccagg	18	11	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:66460498G>C	uc001ojd.2	-	24	5000	c.4928C>G	c.(4927-4929)ACC>AGC	p.T1643S		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1643	Spectrin 13.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTGGTGGATGGTCTGCGCGTA	0.677													0	0	0	1	0	31	80										C	66460498	G	C	66460498	3	2	100	1	0	0	0	0	1	0	0	0	15119	1261	44	4	2300	4	SPTBN2	11	66460498	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1515	66460498	68546018	473	31067										
LRFN4	78999	broad.mit.edu	37	chr11	66625620	66625620	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcaaccagctgggccgcatCgcgccgggagccttcgacga	15	15	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:66625620C>T	uc001ojr.2	+	1	745	c.405C>T	c.(403-405)ATC>ATT	p.I135I	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_Silent_p.I135I|LRFN4_uc001ojs.2_Silent_p.I135I	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	135	LRR 4.|Extracellular (Potential).					integral to membrane					0						TGGGCCGCATCGCGCCGGGAG	0.682													0	0	0	1	0	61	17										T	66625620	C	T	66625620	2	4	100	1	0	0	0	0	0	0	0	1	8940	874	31	1		1	LRFN4	11	66625620	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	165122	66625620	68380896	474	31068										
CORO1B	57175	broad.mit.edu	37	chr11	67207901	67207901	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgcagggccatgggttcctCgaggttttcctggcacattg	13	11	0	0	rs149251927		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:67207901C>G	uc001olj.1	-	6	802	c.766G>C	c.(766-768)GAG>CAG	p.E256Q	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Missense_Mutation_p.E256Q|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Missense_Mutation_p.E256Q	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	256	WD 4.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			ATGGGTTCCTCGAGGTTTTCC	0.622													0	0	0	1	0	8	20										G	67207901	C	G	67207901	3	3	100	1	0	0	0	0	1	0	0	0	3754	893	31	1	723	1	CORO1B	11	67207901	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	582281	67207901	67798615	475	31069										
ARAP1	116985	broad.mit.edu	37	chr11	72412771	72412771	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agccactgtggctcacggtcGgcaggacaactgagtagtgc	14	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:72412771G>A	uc001osu.2	-	16	2414	c.2225C>T	c.(2224-2226)CCG>CTG	p.P742L	ARAP1_uc001osv.2_Missense_Mutation_p.P742L|ARAP1_uc001osr.2_Missense_Mutation_p.P502L|ARAP1_uc001oss.2_Missense_Mutation_p.P497L|ARAP1_uc009yth.2_Missense_Mutation_p.P436L|ARAP1_uc010rre.1_Missense_Mutation_p.P497L|ARAP1_uc001osw.1_Missense_Mutation_p.P30L	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	742					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GCTCACGGTCGGCAGGACAAC	0.632													0	0	0	1	0	68	187										A	72412771	G	A	72412771	3	1	100	1	0	0	0	0	1	0	0	0	838	1116	39	2	2207	2	ARAP1	11	72412771	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5204870	72412771	62593745	476	31070										
RNF169	254225	broad.mit.edu	37	chr11	74547165	74547165	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgatcttgatcatttcccctCtgttagccaaacaaaagcag	6	11	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:74547165C>G	uc001ovl.3	+	6	1530	c.1517C>G	c.(1516-1518)TCT>TGT	p.S506C	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	506							zinc ion binding			ovary(1)	1						CATTTCCCCTCTGTTAGCCAA	0.473													0	0	0	1	0	50	122										G	74547165	C	G	74547165	3	3	100	1	0	0	0	0	1	0	0	0	13460	913	32	1	1539	1	RNF169	11	74547165	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2134394	74547165	60459351	477	31071										
GRM5	2915	broad.mit.edu	37	chr11	88241803	88241803	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtaatctcttatgataagaGtgtcatatttgggagacgac	10	5	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:88241803G>A	uc001pcq.2	-	9	3796	c.3596C>T	c.(3595-3597)ACT>ATT	p.T1199I	GRM5_uc009yvm.2_Missense_Mutation_p.T1167I	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1199	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TATGATAAGAGTGTCATATTT	0.602													0	0	0	1	0	8	18										A	88241803	G	A	88241803	3	1	100	1	0	0	0	0	1	0	0	0	6800	1029	36	2	46	2	GRM5	11	88241803	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	13694638	88241803	46764713	478	31072										
NOX4	50507	broad.mit.edu	37	chr11	89133452	89133452	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acatctgagggatgactcatGaccgaaatgatggtgactgg	13	7	2	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:89133452G>A	uc001pct.2	-	10	1181	c.942C>T	c.(940-942)GTC>GTT	p.V314V	NOX4_uc009yvr.2_Silent_p.V289V|NOX4_uc001pcu.2_Silent_p.V240V|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Silent_p.V314V|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Silent_p.V148V|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Silent_p.V290V|NOX4_uc009yvq.2_Silent_p.V290V	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	314	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GATGACTCATGACCGAAATGA	0.433													0	0	0	1	0	12	54										A	89133452	G	A	89133452	2	1	100	1	0	0	0	0	0	0	0	1	10558	1277	45	1		1	NOX4	11	89133452	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	891649	89133452	45873064	479	31073										
GRIA4	2893	broad.mit.edu	37	chr11	105775959	105775959	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgacagggaatgttcagtttGaccactatggacgtagagtc	12	7	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:105775959G>C	uc001pix.2	+	9	1536	c.1090G>C	c.(1090-1092)GAC>CAC	p.D364H	GRIA4_uc001piu.1_Missense_Mutation_p.D364H|GRIA4_uc001piw.2_Missense_Mutation_p.D364H|GRIA4_uc009yxk.1_Missense_Mutation_p.D364H	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	364	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TGTTCAGTTTGACCACTATGG	0.393													0	0	0	1	0	20	89										C	105775959	G	C	105775959	3	2	100	1	0	0	0	0	1	0	0	0	6770	1290	45	1	1120	1	GRIA4	11	105775959	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	16642507	105775959	29230557	480	31074										
NPAT	4863	broad.mit.edu	37	chr11	108032032	108032032	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacaggtaaatcactactatCagcaagcctacttactgagc	6	12	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:108032032C>T	uc001pjz.3	-	17	3883	c.3781G>A	c.(3781-3783)GAT>AAT	p.D1261N	NPAT_uc010rvv.1_Missense_Mutation_p.D317N	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	1261					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TCACTACTATCAGCAAGCCTA	0.448													0	0	0	1	0	89	85										T	108032032	C	T	108032032	3	4	100	1	0	0	0	0	1	0	0	0	10566	826	29	1	510	1	NPAT	11	108032032	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2256073	108032032	26974484	481	31075										
EXPH5	23086	broad.mit.edu	37	chr11	108384109	108384109	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcttagctgtttgtcttcttCtgaaatagattcatttaagt	7	6	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:108384109C>T	uc001pkk.2	-	6	2236	c.2125G>A	c.(2125-2127)GAA>AAA	p.E709K	EXPH5_uc010rvy.1_Missense_Mutation_p.E521K|EXPH5_uc010rvz.1_Missense_Mutation_p.E553K|EXPH5_uc010rwa.1_Missense_Mutation_p.E633K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	709					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTGTCTTCTTCTGAAATAGAT	0.413													0	0	0	1	0	22	54										T	108384109	C	T	108384109	3	4	100	1	0	0	0	0	1	0	0	0	5322	922	32	1	3848	1	EXPH5	11	108384109	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	352077	108384109	26622407	482	31076										
DRD2	1813	broad.mit.edu	37	chr11	113286260	113286260	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tagaccagcagggtgacaatGaagggcacgtagaaggagac	15	7	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:113286260G>A	uc001pnz.2	-	4	927	c.606C>T	c.(604-606)TTC>TTT	p.F202F	DRD2_uc010rwv.1_Silent_p.F201F|DRD2_uc001poa.3_Silent_p.F202F|DRD2_uc001pob.3_Silent_p.F202F|DRD2_uc009yyr.1_Silent_p.F202F	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	202	Helical; Name=5; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGGTGACAATGAAGGGCACGT	0.597													0	0	0	1	0	27	43										A	113286260	G	A	113286260	2	1	100	1	0	0	0	0	0	0	0	1	4757	1281	45	1		1	DRD2	11	113286260	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4902151	113286260	21720256	483	31077										
DSCAML1	57453	broad.mit.edu	37	chr11	117332172	117332172	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagcagactcacccccatCaacatagagggaccagaaga	8	15	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:117332172C>T	uc001prh.1	-	18	3588	c.3586G>A	c.(3586-3588)GAT>AAT	p.D1196N		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1136	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TCACCCCCATCAACATAGAGG	0.602													0	0	0	1	0	27	44										T	117332172	C	T	117332172	3	4	100	1	0	0	0	0	1	0	0	0	4769	826	29	1	2819	1	DSCAML1	11	117332172	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4045912	117332172	17674344	484	31078										
AMICA1	120425	broad.mit.edu	37	chr11	118071280	118071280	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcccacaatgatcaccaactGattaccacccaagaccagag	5	15	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:118071280G>T	uc001psk.2	-	7	994	c.820C>A	c.(820-822)CAG>AAG	p.Q274K	AMICA1_uc001psg.2_Missense_Mutation_p.Q84K|AMICA1_uc001psh.2_Missense_Mutation_p.Q235K|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.Q264K|AMICA1_uc001psj.2_Missense_Mutation_p.Q263K|AMICA1_uc010rxw.1_Missense_Mutation_p.Q235K|AMICA1_uc010rxx.1_Missense_Mutation_p.Q274K|AMICA1_uc001psl.1_Missense_Mutation_p.Q230K	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	274	Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ATCACCAACTGATTACCACCC	0.502													1	0	4.87955e-14	1	5.32458e-14	26	41										T	118071280	G	T	118071280	3	4	100	1	0	0	0	0	1	0	0	0	574	1299	45	3	380	3	AMICA1	11	118071280	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	739108	118071280	16935236	485	31079										
MLL	4297	broad.mit.edu	37	chr11	118363895	118363895	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggatgatcagcagcctttaGatctagaaggagtcaagagg	13	6	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:118363895G>A	uc001pta.2	+	16	5142	c.5119G>A	c.(5119-5121)GAT>AAT	p.D1707N	MLL_uc001ptb.2_Missense_Mutation_p.D1710N	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1707	Bromo; divergent.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GCAGCCTTTAGATCTAGAAGG	0.478			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	1	0	16	96										A	118363895	G	A	118363895	3	1	100	1	0	0	0	0	1	0	0	0	9620	942	33	1	5181	1	MLL	11	118363895	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	292615	118363895	16642621	486	31080										
HYOU1	10525	broad.mit.edu	37	chr11	118923444	118923444	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acgcgggttctcccgcacatCctttgctctctgacccttgc	8	17	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:118923444C>G	uc001puu.2	-	9	1085	c.892G>C	c.(892-894)GAT>CAT	p.D298H	HYOU1_uc001put.2_Missense_Mutation_p.D263H|HYOU1_uc010ryu.1_Missense_Mutation_p.D318H|HYOU1_uc010ryv.1_Missense_Mutation_p.D187H|HYOU1_uc001pux.3_Missense_Mutation_p.D298H|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.D298H	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	298						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		TCCCGCACATCCTTTGCTCTC	0.612													0	0	0	1	0	8	23										G	118923444	C	G	118923444	3	3	100	1	0	0	0	0	1	0	0	0	7470	855	30	1	2179	1	HYOU1	11	118923444	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	559549	118923444	16083072	487	31081										
ARHGEF12	23365	broad.mit.edu	37	chr11	120292558	120292558	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagacaggtgatcgaatcatCaaggtaaggaataggctatt	11	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:120292558C>G	uc001pxl.1	+	6	352	c.345C>G	c.(343-345)ATC>ATG	p.I115M	ARHGEF12_uc009zat.2_Missense_Mutation_p.I96M|ARHGEF12_uc010rzn.1_Missense_Mutation_p.I12M|ARHGEF12_uc009zau.1_Missense_Mutation_p.I12M	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	115	PDZ.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATCGAATCATCAAGGTAAGGA	0.333			T	MLL	AML								0	0	0	1	0	12	52										G	120292558	C	G	120292558	3	3	100	1	0	0	0	0	1	0	0	0	897	816	29	1	367	1	ARHGEF12	11	120292558	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1369114	120292558	14713958	488	31082										
OR8G2	26492	broad.mit.edu	37	chr11	124096005	124096005	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctcttggggctctcctgctCcagcacctacatcaatgaat	7	14	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:124096005C>T	uc010saf.1	+	1	608	c.608C>T	c.(607-609)TCC>TTC	p.S203F		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	203						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CTCTCCTGCTCCAGCACCTAC	0.423													0	0	0	1	0	45	247										T	124096005	C	T	124096005	3	4	100	1	0	0	0	0	1	0	0	0	11235	855	30	1	610	1	OR8G2	11	124096005	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3803447	124096005	10910511	489	31083										
APLP2	334	broad.mit.edu	37	chr11	129999042	129999042	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagtggaagctatgctgaatGaccgccgtcggatggctctg	15	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:129999042G>A	uc010sby.1	+	10	1553	c.1396G>A	c.(1396-1398)GAC>AAC	p.D466N	APLP2_uc001qfp.2_Missense_Mutation_p.D466N|APLP2_uc001qfq.2_Missense_Mutation_p.D410N|APLP2_uc010sbz.1_Missense_Mutation_p.D254N|APLP2_uc001qfr.2_Missense_Mutation_p.D232N|APLP2_uc001qfs.2_Missense_Mutation_p.D237N|APLP2_uc001qfv.2_Missense_Mutation_p.D357N	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	466	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TATGCTGAATGACCGCCGTCG	0.592													0	0	0	1	0	42	26										A	129999042	G	A	129999042	3	1	100	1	0	0	0	0	1	0	0	0	779	1290	45	1	1434	1	APLP2	11	129999042	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5903037	129999042	5007474	490	31084										
KDM5A	5927	broad.mit.edu	37	chr12	442723	442723	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgcagaagatcaggctggGattcaaataactcgggggcc	14	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:442723G>C	uc001qif.1	-	12	1946	c.1583C>G	c.(1582-1584)TCC>TGC	p.S528C	KDM5A_uc001qie.1_Missense_Mutation_p.S528C|KDM5A_uc010sdn.1_Missense_Mutation_p.S487C|KDM5A_uc010sdo.1_Missense_Mutation_p.S147C	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	528	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						ATCAGGCTGGGATTCAAATAA	0.502			T 	NUP98	AML								0	0	0	1	0	22	45										C	442723	G	C	442723	3	2	100	1	0	0	0	0	1	0	0	0	8133	1174	41	1	3557	1	KDM5A	12	442723	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		442723	133409172	491	31085										
NOP2	4839	broad.mit.edu	37	chr12	6672897	6672897	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctcaggggtcacttctttctCttcctcctcgtcctcggtct	7	16	5	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:6672897C>G	uc001qpk.1	-	6	615	c.571G>C	c.(571-573)GAG>CAG	p.E191Q	NOP2_uc009zeq.1_5'Flank|NOP2_uc001qph.1_Missense_Mutation_p.E187Q|NOP2_uc001qpi.1_Missense_Mutation_p.E187Q|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Missense_Mutation_p.E224Q|NOP2_uc001qpm.1_Missense_Mutation_p.E191Q			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	191					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						ACTTCTTTCTCTTCCTCCTCG	0.547											OREG0021630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	4	25										G	6672897	C	G	6672897	3	3	100	1	0	0	0	0	1	0	0	0	10538	922	32	1	1907	1	NOP2	12	6672897	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6230174	6672897	127178998	492	31086										
ING4	51147	broad.mit.edu	37	chr12	6761554	6761554	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggggtggacactgccaaaGgtcactgagggcatcccata	14	10	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:6761554G>C	uc001qpw.3	-	6	572	c.531C>G	c.(529-531)ACC>ACG	p.T177T	ING4_uc001qpv.3_Silent_p.T176T|ING4_uc001qpy.3_Silent_p.T173T|ING4_uc001qpx.3_Silent_p.T174T|ING4_uc009zes.2_Intron|ING4_uc009zet.2_Silent_p.T153T|ING4_uc009zeu.2_Intron|ING4_uc009zev.2_RNA	NM_001127582	NP_001121054	Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4 isoform 9	177					apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|ovary(1)	4						CACTGCCAAAGGTCACTGAGG	0.512													0	0	0	1	0	28	112										C	6761554	G	C	6761554	2	2	100	1	0	0	0	0	0	0	0	1	7738	987	35	4		4	ING4	12	6761554	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	88657	6761554	127090341	493	31087										
A2M	2	broad.mit.edu	37	chr12	9229519	9229519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccaggcaaaacagggcattgCggacaacagggtgctgtgaa	14	9	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:9229519C>T	uc001qvk.1	-	28	3478	c.3365G>A	c.(3364-3366)CGC>CAC	p.R1122H	A2M_uc001qvj.1_Missense_Mutation_p.R164H|A2M_uc009zgk.1_Missense_Mutation_p.R972H	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1122					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CAGGGCATTGCGGACAACAGG	0.502													0	0	0	1	0	31	63										T	9229519	C	T	9229519	3	4	100	1	0	0	0	0	1	0	0	0	4	768	27	2	1095	2	A2M	12	9229519	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2467965	9229519	124622376	494	31088										
PZP	5858	broad.mit.edu	37	chr12	9305844	9305844	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggaaatttgtagaaaaggtCtgtgaatcctgaacggtgac	12	5	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:9305844C>T	uc001qvl.2	-	30	3899	c.3870G>A	c.(3868-3870)CAG>CAA	p.Q1290Q	PZP_uc009zgl.2_Silent_p.Q1076Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TAGAAAAGGTCTGTGAATCCT	0.478													0	0	0	1	0	57	77										T	9305844	C	T	9305844	2	4	100	1	0	0	0	0	0	0	0	1	12869	912	32	1		1	PZP	12	9305844	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	76325	9305844	124546051	495	31089										
LOH12CR1	118426	broad.mit.edu	37	chr12	12588569	12588569	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttctcctttgaagggctattGagtggccagacttccccaac	9	12	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:12588569G>C	uc001ral.2	+	3	576	c.210G>C	c.(208-210)TTG>TTC	p.L70F	LOH12CR1_uc009zhu.2_Missense_Mutation_p.L22F	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	LOH1CR12	70										ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		AAGGGCTATTGAGTGGCCAGA	0.403													0	0	0	1	0	12	52										C	12588569	G	C	12588569	3	2	100	1	0	0	0	0	1	0	0	0	8891	1281	45	1	220	1	LOH12CR1	12	12588569	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3282725	12588569	121263326	496	31090										
LRMP	4033	broad.mit.edu	37	chr12	25260856	25260856	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attgtactgtttgcagctttGatgagcttcctcacaggcca	9	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:25260856G>C	uc001rgh.2	+	21	2396	c.1362G>C	c.(1360-1362)TTG>TTC	p.L454F	LRMP_uc010sja.1_Missense_Mutation_p.L454F|LRMP_uc010sjb.1_Missense_Mutation_p.L401F|LRMP_uc001rgi.2_RNA|LRMP_uc010sjc.1_Missense_Mutation_p.L454F|LRMP_uc010sjd.1_Missense_Mutation_p.L401F	NM_006152	NP_006143	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	510	Helical; Anchor for type IV membrane protein; (Potential).				vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					TTGCAGCTTTGATGAGCTTCC	0.473													0	0	0	1	0	32	104										C	25260856	G	C	25260856	3	2	100	1	0	0	0	0	1	0	0	0	8950	1281	45	1	1428	1	LRMP	12	25260856	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	12672287	25260856	108591039	497	31091										
RASSF8	11228	broad.mit.edu	37	chr12	26217937	26217937	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtataattccaaccttgaaGaggaaattgtccgtctagag	9	7	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:26217937G>C	uc001rgx.2	+	3	831	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	RASSF8_uc001rgy.2_Missense_Mutation_p.E204Q|RASSF8_uc001rgz.2_Missense_Mutation_p.E204Q|RASSF8_uc009zjd.1_Missense_Mutation_p.E204Q|RASSF8_uc009zje.1_Missense_Mutation_p.E204Q	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	204	Glu-rich.				signal transduction						0	Colorectal(261;0.0847)					CAACCTTGAAGAGGAAATTGT	0.363													0	0	0	1	0	7	58										C	26217937	G	C	26217937	3	2	100	1	0	0	0	0	1	0	0	0	13092	943	33	1	616	1	RASSF8	12	26217937	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	957081	26217937	107633958	498	31092										
STK38L	23012	broad.mit.edu	37	chr12	27455101	27455101	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tagaagtggccatggaagaaGaaggattagcagatgaagag	15	3	0	6			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:27455101G>C	uc001rhr.2	+	3	365	c.166G>C	c.(166-168)GAA>CAA	p.E56Q	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.E4Q	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	56					intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					CATGGAAGAAGAAGGATTAGC	0.299													0	0	0	1	0	47	72										C	27455101	G	C	27455101	3	2	100	1	0	0	0	0	1	0	0	0	15303	943	33	1	172	1	STK38L	12	27455101	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1237164	27455101	106396794	499	31093										
PPFIBP1	8496	broad.mit.edu	37	chr12	27788022	27788022	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagattcaacagcagaaacgCttgttgaatggcttcagagt	10	8	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:27788022C>G	uc001ric.1	+	4	621	c.244C>G	c.(244-246)CTT>GTT	p.L82V	PPFIBP1_uc001rhy.1_Missense_Mutation_p.L82V|PPFIBP1_uc001rhz.1_Missense_Mutation_p.L82V|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.L82V|PPFIBP1_uc001ria.2_Missense_Mutation_p.L82V|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	82					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					AGCAGAAACGCTTGTTGAATG	0.413													0	0	0	1	0	23	53										G	27788022	C	G	27788022	3	3	100	1	0	0	0	0	1	0	0	0	12313	797	28	4	250	4	PPFIBP1	12	27788022	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	332921	27788022	106063873	500	31094										
IRAK4	51135	broad.mit.edu	37	chr12	44180267	44180267	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gattatattgataaaaagatGaatgatgctgattccacttc	7	5	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:44180267G>C	uc001rnu.3	+	12	1384	c.1254G>C	c.(1252-1254)ATG>ATC	p.M418I	IRAK4_uc001rnt.3_Missense_Mutation_p.M418I|IRAK4_uc001rnx.3_Missense_Mutation_p.M294I|IRAK4_uc001rny.3_Missense_Mutation_p.M294I|IRAK4_uc010sky.1_Missense_Mutation_p.M294I|IRAK4_uc001rnv.3_Missense_Mutation_p.M294I|IRAK4_uc001rnw.3_Missense_Mutation_p.M294I	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	418	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		ATAAAAAGATGAATGATGCTG	0.303													0	0	0	1	0	18	75										C	44180267	G	C	44180267	3	2	100	1	0	0	0	0	1	0	0	0	7825	1290	45	1	1292	1	IRAK4	12	44180267	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	16392245	44180267	89671628	501	31095										
SLC38A2	54407	broad.mit.edu	37	chr12	46764968	46764968	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caacttctcccaccttttcaGagcagcttgcttggtggggt	10	12	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:46764968G>A	uc001rpg.2	-	2	549	c.109C>T	c.(109-111)CTG>TTG	p.L37L	SLC38A2_uc001rph.2_5'UTR	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	37	Cytoplasmic (Potential).|Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		CACCTTTTCAGAGCAGCTTGC	0.488													0	0	0	1	0	8	127										A	46764968	G	A	46764968	2	1	100	1	0	0	0	0	0	0	0	1	14604	933	33	1		1	SLC38A2	12	46764968	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2584701	46764968	87086927	502	31096										
AMIGO2	347902	broad.mit.edu	37	chr12	47472633	47472633	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttttgttggtgcagctgacGatgtcagtggcacagatgca	13	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:47472633G>T	uc001rpm.2	-	3	808	c.153C>A	c.(151-153)ATC>ATA	p.I51I	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Silent_p.I51I|AMIGO2_uc001rpl.2_Silent_p.I51I	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	51	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					TGCAGCTGACGATGTCAGTGG	0.542													1	0	1.56442e-22	1	1.75029e-22	33	62										T	47472633	G	T	47472633	2	4	100	1	0	0	0	0	0	0	0	1	576	1048	37	3		3	AMIGO2	12	47472633	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	707665	47472633	86379262	503	31097										
DDX23	9416	broad.mit.edu	37	chr12	49226345	49226345	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctgggggcatggtggccgtGaacatgactgtctacgaaaa	15	8	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:49226345G>A	uc001rsm.2	-	14	1906	c.1815C>T	c.(1813-1815)TTC>TTT	p.F605F		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	605	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TGGTGGCCGTGAACATGACTG	0.587													0	0	0	1	0	9	41										A	49226345	G	A	49226345	2	1	100	1	0	0	0	0	0	0	0	1	4350	1281	45	1		1	DDX23	12	49226345	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1753712	49226345	84625550	504	31098										
MLL2	8085	broad.mit.edu	37	chr12	49424126	49424126	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggggtgctcccccagctcttCagatggggtgacgccattca	13	13	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:49424126C>T	uc001rta.3	-	42	13936	c.13936G>A	c.(13936-13938)GAA>AAA	p.E4646K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4646					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCAGCTCTTCAGATGGGGTG	0.612			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	1	0	5	6										T	49424126	C	T	49424126	3	4	100	1	0	0	0	0	1	0	0	0	9621	835	29	1	2729	1	MLL2	12	49424126	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	197781	49424126	84427769	505	31099										
NCKAP5L	57701	broad.mit.edu	37	chr12	50195682	50195682	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttctgctgaaacagggcactCagcatctggttctgccgttc	10	12	4	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:50195682C>T	uc009zlk.2	-	6	502	c.300G>A	c.(298-300)CTG>CTA	p.L100L		NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	96	Potential.									central_nervous_system(1)	1						ACAGGGCACTCAGCATCTGGT	0.592													0	0	0	1	0	15	66										T	50195682	C	T	50195682	2	4	100	1	0	0	0	0	0	0	0	1	10224	813	29	1		1	NCKAP5L	12	50195682	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	771556	50195682	83656213	506	31100										
LIMA1	51474	broad.mit.edu	37	chr12	50598415	50598415	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctttatagaggtttctgagaGgcgtggaagttccagatttc	12	6	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:50598415G>C	uc001rwj.3	-	6	958	c.784C>G	c.(784-786)CTC>GTC	p.L262V	LIMA1_uc001rwg.3_5'Flank|LIMA1_uc001rwh.3_Missense_Mutation_p.L102V|LIMA1_uc001rwi.3_Missense_Mutation_p.L102V|LIMA1_uc001rwk.3_Missense_Mutation_p.L262V|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	262					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						GTTTCTGAGAGGCGTGGAAGT	0.403													0	0	0	1	0	54	62										C	50598415	G	C	50598415	3	2	100	1	0	0	0	0	1	0	0	0	8796	1000	35	4	1522	4	LIMA1	12	50598415	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	402733	50598415	83253480	507	31101										
KRT84	3890	broad.mit.edu	37	chr12	52774948	52774948	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgttccgtatgttgcgcagGttgtcacagtgttggccagc	13	10	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:52774948G>A	uc001sah.1	-	6	1167	c.1119C>T	c.(1117-1119)AAC>AAT	p.N373N		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	373	Rod.|Coil 2.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTTGCGCAGGTTGTCACAGT	0.557													0	0	0	1	0	40	144										A	52774948	G	A	52774948	2	1	100	1	0	0	0	0	0	0	0	1	8498	1252	44	2		2	KRT84	12	52774948	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2176533	52774948	81076947	508	31102										
KRT84	3890	broad.mit.edu	37	chr12	52776813	52776813	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcagagccacaaactcattCtcagcattggcccgacatac	6	14	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:52776813C>G	uc001sah.1	-	3	840	c.792G>C	c.(790-792)GAG>GAC	p.E264D		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	264	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAAACTCATTCTCAGCATTGG	0.502													0	0	0	1	0	18	59										G	52776813	C	G	52776813	3	3	100	1	0	0	0	0	1	0	0	0	8498	912	32	1	1038	1	KRT84	12	52776813	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1865	52776813	81075082	509	31103										
KRT4	3851	broad.mit.edu	37	chr12	53204577	53204577	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtcattctcggctgctgtgCgtttgttgatctcctcttca	9	11	5	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:53204577C>T	uc001saz.2	-	3	1194	c.923G>A	c.(922-924)CGC>CAC	p.R308H		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	234						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GGCTGCTGTGCGTTTGTTGAT	0.517													0	0	0	1	0	16	53										T	53204577	C	T	53204577	3	4	100	1	0	0	0	0	1	0	0	0	8477	768	27	2	889	2	KRT4	12	53204577	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	427764	53204577	80647318	510	31104										
SP7	121340	broad.mit.edu	37	chr12	53723022	53723022	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggagcccattagtgcttgtAaagggggctggataagcatc	14	7	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:53723022A>T	uc001sct.2	-	2	311	c.204T>A	c.(202-204)TTT>TTA	p.F68L	SP7_uc001scu.2_Missense_Mutation_p.F50L|SP7_uc001scv.2_Missense_Mutation_p.F68L	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGTGCTTGTAAAGGGGGCTG	0.542													0	0	0	1	0	30	139										T	53723022	A	T	53723022	3	4	100	1	0	0	0	0	1	0	0	0	14969	359	13	5	1095	5	SP7	12	53723022	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	518445	53723022	80128873	511	31105										
ATF7	11016	broad.mit.edu	37	chr12	53918472	53918472	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctccagaaagcgctgccgtCgctcatctggatcttcatct	9	14	5	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:53918472C>T	uc001sdy.2	-	9	1055	c.1034G>A	c.(1033-1035)CGA>CAA	p.R345Q	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.R334Q|ATF7_uc010sol.1_Missense_Mutation_p.R313Q	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	345	Basic motif.|Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GCGCTGCCGTCGCTCATCTGG	0.622													0	0	0	1	0	8	23										T	53918472	C	T	53918472	3	4	100	1	0	0	0	0	1	0	0	0	1086	884	31	1	462	1	ATF7	12	53918472	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	195450	53918472	79933423	512	31106										
DNAJC14	85406	broad.mit.edu	37	chr12	56188173	56188173	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aactgaagaaatcccaaaccTgaagaaggaaaaacaaacta	6	8	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56188173T>C	uc001shu.1	-	12	2483	c.2427_splice	c.e12-1	p.R809_splice	SARNP_uc009zoa.2_Splice_Site|SARNP_uc001shs.3_Splice_Site|SARNP_uc001sht.2_Splice_Site_p.R126_splice|SARNP_uc001shv.3_Intron	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein						protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						ATCCCAAACCTGAAGAAGGAA	0.358													0	0	0	1	0	69	234										C	56188173	T	C	56188173	5	2	100	1	0	0	0	0	0	0	1	0	4633	1594	55	5		5	DNAJC14	12	56188173	Splice_Site	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	2269701	56188173	77663722	513	31107										
DNAJC14	85406	broad.mit.edu	37	chr12	56215880	56215880	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcaggctgaggagctgcaaAgaagttcccattgggcatct	14	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56215880A>G	uc001shx.1	-	7	2194	c.1990T>C	c.(1990-1992)TTT>CTT	p.F664L	DNAJC14_uc001shu.1_Missense_Mutation_p.F664L|DNAJC14_uc009zob.1_Missense_Mutation_p.F664L	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	664					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						GGAGCTGCAAAGAAGTTCCCA	0.567													0	0	0	1	0	20	56										G	56215880	A	G	56215880	3	3	100	1	0	0	0	0	1	0	0	0	4633	72	3	5	122	5	DNAJC14	12	56215880	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	27707	56215880	77636015	514	31108										
SILV	6490	broad.mit.edu	37	chr12	56351734	56351734	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtgaaggctgagctggaatGagcaagaggcacatagctcc	15	8	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56351734G>C	uc001sip.2	-	5	635	c.604C>G	c.(604-606)CAT>GAT	p.H202D	SILV_uc001siq.2_Missense_Mutation_p.H202D|SILV_uc010spx.1_Missense_Mutation_p.H116D|SILV_uc001sir.2_Missense_Mutation_p.H202D	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	202					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GAGCTGGAATGAGCAAGAGGC	0.572													0	0	0	1	0	31	50										C	56351734	G	C	56351734	3	2	100	1	0	0	0	0	1	0	0	0	14322	1290	45	1	1409	1	SILV	12	56351734	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	135854	56351734	77500161	515	31109										
SILV	6490	broad.mit.edu	37	chr12	56351767	56351767	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atagctccgggatccccggcGatggtagacagtcacttcca	11	13	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56351767G>A	uc001sip.2	-	5	602	c.571C>T	c.(571-573)CGC>TGC	p.R191C	SILV_uc001siq.2_Missense_Mutation_p.R191C|SILV_uc010spx.1_Missense_Mutation_p.R105C|SILV_uc001sir.2_Missense_Mutation_p.R191C	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	191					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GATCCCCGGCGATGGTAGACA	0.572													0	0	0	1	0	27	48										A	56351767	G	A	56351767	3	1	100	1	0	0	0	0	1	0	0	0	14322	1058	37	1	1442	1	SILV	12	56351767	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	33	56351767	77500128	516	31110										
SMARCC2	6601	broad.mit.edu	37	chr12	56565672	56565672	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actcgtcctgtgtgcggcttCccacatgctcggacactttg	10	14	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56565672C>T	uc001skb.2	-	20	1989	c.1883G>A	c.(1882-1884)GGA>GAA	p.G628E	SMARCC2_uc001skd.2_Missense_Mutation_p.G659E|SMARCC2_uc001ska.2_Missense_Mutation_p.G659E|SMARCC2_uc001skc.2_Missense_Mutation_p.G658E|SMARCC2_uc010sqf.1_Missense_Mutation_p.G548E	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	628	SANT.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGTGCGGCTTCCCACATGCTC	0.527													0	0	0	1	0	22	25										T	56565672	C	T	56565672	3	4	100	1	0	0	0	0	1	0	0	0	14776	855	30	1	1797	1	SMARCC2	12	56565672	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	213905	56565672	77286223	517	31111										
TIMELESS	8914	broad.mit.edu	37	chr12	56817644	56817644	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcctctggagaaatgtcttGagagccaaacacatctcctt	7	11	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56817644G>C	uc001slf.2	-	16	2071	c.1903C>G	c.(1903-1905)CAA>GAA	p.Q635E		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	635					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GAAATGTCTTGAGAGCCAAAC	0.473													0	0	0	1	0	32	52										C	56817644	G	C	56817644	3	2	100	1	0	0	0	0	1	0	0	0	15901	1299	45	1	1779	1	TIMELESS	12	56817644	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	251972	56817644	77034251	518	31112										
TIMELESS	8914	broad.mit.edu	37	chr12	56818562	56818562	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttaccgagcagacctcaggaGagtcagggcctgtggggcct	15	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56818562G>C	uc001slf.2	-	15	2020	c.1852C>G	c.(1852-1854)CTC>GTC	p.L618V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	618					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GACCTCAGGAGAGTCAGGGCC	0.597													0	0	0	1	0	38	57										C	56818562	G	C	56818562	3	2	100	1	0	0	0	0	1	0	0	0	15901	942	33	1	1834	1	TIMELESS	12	56818562	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	918	56818562	77033333	519	31113										
DPY19L2	283417	broad.mit.edu	37	chr12	64061860	64061860	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgccgagagtggttctgctgGagaaccgccgcgcctgcagt	15	12	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:64061860G>C	uc001srp.1	-	1	495	c.314C>G	c.(313-315)TCC>TGC	p.S105C	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	105					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GGTTCTGCTGGAGAACCGCCG	0.592													0	0	0	1	0	45	51										C	64061860	G	C	64061860	3	2	100	1	0	0	0	0	1	0	0	0	4741	1174	41	1	2050	1	DPY19L2	12	64061860	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7243298	64061860	69790035	520	31114										
HELB	92797	broad.mit.edu	37	chr12	66698778	66698778	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aacatgggtaaaggaggtatCaaactacaaaaacctaaact	7	7	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:66698778C>G	uc001sti.2	+	2	483	c.455C>G	c.(454-456)TCA>TGA	p.S152*	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	152					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AAGGAGGTATCAAACTACAAA	0.358													0	0	0	1	0	22	48										G	66698778	C	G	66698778	4	3	100	1	0	0	0	0	0	1	0	0	7045	838	29	1	461	1	HELB	12	66698778	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2636918	66698778	67153117	521	31115										
CCT2	10576	broad.mit.edu	37	chr12	69991012	69991012	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaacttatcgaggaagtcatGattggagaagacaaactcat	9	6	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:69991012G>T	uc001svb.1	+	11	1153	c.1059G>T	c.(1057-1059)ATG>ATT	p.M353I	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.M353I|CCT2_uc010stl.1_Missense_Mutation_p.M306I	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	353					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGGAAGTCATGATTGGAGAAG	0.413													1	0	7.63117e-38	1	8.63282e-38	83	108										T	69991012	G	T	69991012	3	4	100	1	0	0	0	0	1	0	0	0	2953	1290	45	3	1101	3	CCT2	12	69991012	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3292234	69991012	63860883	522	31116										
ZFC3H1	196441	broad.mit.edu	37	chr12	72017272	72017272	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atcataaaattttgaagggaGaatgttgaattcaataagat	8	2	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:72017272G>C	uc001swo.2	-	24	4971	c.4612C>G	c.(4612-4614)CTC>GTC	p.L1538V		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1538					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTTGAAGGGAGAATGTTGAAT	0.343													0	0	0	1	0	7	119										C	72017272	G	C	72017272	3	2	100	1	0	0	0	0	1	0	0	0	17630	942	33	1	1405	1	ZFC3H1	12	72017272	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2026260	72017272	61834623	523	31117										
BBS10	79738	broad.mit.edu	37	chr12	76740913	76740913	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ataatccaaaattgagatgtCtgaaactgtgcttctgaatt	7	6	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:76740913C>G	uc001syd.1	-	2	936	c.852G>C	c.(850-852)CAG>CAC	p.Q284H		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	284					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						ATTGAGATGTCTGAAACTGTG	0.348									Bardet-Biedl_syndrome				0	0	0	1	0	16	20										G	76740913	C	G	76740913	3	3	100	1	0	0	0	0	1	0	0	0	1336	912	32	1	1323	1	BBS10	12	76740913	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4723641	76740913	57110982	524	31118										
SYT1	6857	broad.mit.edu	37	chr12	79837968	79837968	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagtcattcagctttgaagtAccttttgaacaaatccaggt	8	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:79837968A>C	uc001sys.2	+	11	1715	c.1044A>C	c.(1042-1044)GTA>GTC	p.V348V	SYT1_uc001syt.2_Silent_p.V348V|SYT1_uc001syu.2_Silent_p.V345V|SYT1_uc001syv.2_Silent_p.V348V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	348	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 2.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						GCTTTGAAGTACCTTTTGAAC	0.353													0	0	0	1	0	27	183										C	79837968	A	C	79837968	2	2	100	1	0	0	0	0	0	0	0	1	15462	378	14	5		5	SYT1	12	79837968	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	3097055	79837968	54013927	525	31119										
PPP1R12A	4659	broad.mit.edu	37	chr12	80266706	80266706	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcaccatatcaacattgtCatcaatgcaagcctaaaaac	3	12	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:80266706C>G	uc001syz.2	-	2	517	c.250G>C	c.(250-252)GAC>CAC	p.D84H	PPP1R12A_uc010suc.1_5'UTR|PPP1R12A_uc001sza.2_Missense_Mutation_p.D84H|PPP1R12A_uc010sud.1_Missense_Mutation_p.D84H|PPP1R12A_uc001szb.2_Missense_Mutation_p.D84H|PPP1R12A_uc001szc.2_Missense_Mutation_p.D84H	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	84	ANK 2.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						TCAACATTGTCATCAATGCAA	0.343													0	0	0	1	0	4	30										G	80266706	C	G	80266706	3	3	100	1	0	0	0	0	1	0	0	0	12354	826	29	1	2938	1	PPP1R12A	12	80266706	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	428738	80266706	53585189	526	31120										
ACSS3	79611	broad.mit.edu	37	chr12	81647169	81647169	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtcatgtccccttagcactCtgtgtattgagaaaaggtga	11	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:81647169C>G	uc001szl.1	+	14	1894	c.1803C>G	c.(1801-1803)CTC>CTG	p.L601L	ACSS3_uc001szm.1_Silent_p.L600L|ACSS3_uc001szn.1_Silent_p.L283L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	601						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTTAGCACTCTGTGTATTGA	0.428													0	0	0	1	0	37	161										G	81647169	C	G	81647169	2	3	100	1	0	0	0	0	0	0	0	1	190	900	32	1		1	ACSS3	12	81647169	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1380463	81647169	52204726	527	31121										
LRRIQ1	84125	broad.mit.edu	37	chr12	85449499	85449499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atggcccaattattaaagagCaaattgaaagtaagaaaagg	9	4	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:85449499C>A	uc001tac.2	+	8	1039	c.928C>A	c.(928-930)CAA>AAA	p.Q310K	LRRIQ1_uc001tab.1_Missense_Mutation_p.Q310K|LRRIQ1_uc001taa.1_Missense_Mutation_p.Q285K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	310	IQ 1.|Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TATTAAAGAGCAAATTGAAAG	0.154													1	0	5.9392e-07	1	6.22056e-07	6	35										A	85449499	C	A	85449499	3	1	100	1	0	0	0	0	1	0	0	0	9029	711	25	4	954	4	LRRIQ1	12	85449499	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3802330	85449499	48402396	528	31122										
LRRIQ1	84125	broad.mit.edu	37	chr12	85517896	85517896	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatctctgtcattattttaaGaaattgatgatacttagtac	5	5	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:85517896G>A	uc001tac.2	+	17	3717	c.3606G>A	c.(3604-3606)AAG>AAA	p.K1202K	LRRIQ1_uc001tab.1_Silent_p.K1202K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1202										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATTATTTTAAGAAATTGATGA	0.333													0	0	0	1	0	12	54										A	85517896	G	A	85517896	2	1	100	1	0	0	0	0	0	0	0	1	9029	933	33	1		1	LRRIQ1	12	85517896	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	68397	85517896	48333999	529	31123										
MGAT4C	25834	broad.mit.edu	37	chr12	86374166	86374166	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgtctcaagtaaatagtttCctttttttcgctttactgaa	5	7	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:86374166C>A	uc001tai.3	-	8	1588	c.338G>T	c.(337-339)GGA>GTA	p.G113V	MGAT4C_uc001tal.3_Missense_Mutation_p.G113V|MGAT4C_uc001taj.3_Missense_Mutation_p.G113V|MGAT4C_uc001tak.3_Missense_Mutation_p.G113V|MGAT4C_uc010sum.1_Missense_Mutation_p.G137V|MGAT4C_uc001tah.3_Missense_Mutation_p.G113V	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	113	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TAAATAGTTTCCTTTTTTTCG	0.328													1	0	8.34094e-07	1	8.70917e-07	21	21										A	86374166	C	A	86374166	3	1	100	1	0	0	0	0	1	0	0	0	9547	855	30	3	1102	3	MGAT4C	12	86374166	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	856270	86374166	47477729	530	31124										
NEDD1	121441	broad.mit.edu	37	chr12	97331111	97331111	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccacgtccattgccacagttCtaccacaacctatgacatca	4	16	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:97331111C>G	uc001teu.3	+	9	1396	c.1057C>G	c.(1057-1059)CTA>GTA	p.L353V	NEDD1_uc001tev.3_Missense_Mutation_p.L353V|NEDD1_uc010svc.1_Missense_Mutation_p.L264V|NEDD1_uc001tew.2_Missense_Mutation_p.L360V|NEDD1_uc001tex.2_Missense_Mutation_p.L264V	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	353					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TGCCACAGTTCTACCACAACC	0.428													0	0	0	1	0	20	114										G	97331111	C	G	97331111	3	3	100	1	0	0	0	0	1	0	0	0	10309	912	32	1	1108	1	NEDD1	12	97331111	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	10956945	97331111	36520784	531	31125										
UTP20	27340	broad.mit.edu	37	chr12	101776903	101776903	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcaaagtaagataaaagaaGacctggaagaacaagaagct	10	5	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:101776903G>C	uc001tia.1	+	59	7897	c.7741G>C	c.(7741-7743)GAC>CAC	p.D2581H		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2581					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GATAAAAGAAGACCTGGAAGA	0.418													0	0	0	1	0	21	31										C	101776903	G	C	101776903	3	2	100	1	0	0	0	0	1	0	0	0	17096	942	33	1	7975	1	UTP20	12	101776903	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4445792	101776903	32074992	532	31126										
CCDC53	51019	broad.mit.edu	37	chr12	102433677	102433677	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttttgagatatctggcatatCttggatccttggctacagtt	9	7	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:102433677C>A	uc010svw.1	-	5	563	c.404G>T	c.(403-405)AGA>ATA	p.R135I	CCDC53_uc010svx.1_RNA|CCDC53_uc010svy.1_RNA|CCDC53_uc010svz.1_Missense_Mutation_p.R134I	NM_016053	NP_057137	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	135						WASH complex	protein binding				0						TCTGGCATATCTTGGATCCTT	0.403													1	0	8.72158e-25	1	9.81178e-25	60	67										A	102433677	C	A	102433677	3	1	100	1	0	0	0	0	1	0	0	0	2823	913	32	3	123	3	CCDC53	12	102433677	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	656774	102433677	31418218	533	31127										
STAB2	55576	broad.mit.edu	37	chr12	104049332	104049332	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgaataacatgaaggacggCactctcgattacctcctttc	7	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:104049332C>A	uc001tjw.2	+	15	1893	c.1707C>A	c.(1705-1707)GGC>GGA	p.G569G		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	569	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TGAAGGACGGCACTCTCGATT	0.453													1	0	1.5842e-08	1	1.67477e-08	13	40										A	104049332	C	A	104049332	2	1	100	1	0	0	0	0	0	0	0	1	15237	697	25	4		4	STAB2	12	104049332	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1615655	104049332	29802563	534	31128										
STAB2	55576	broad.mit.edu	37	chr12	104142822	104142822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggcacgaaggtctcctgcaGctgccagaagggatacaaag	14	10	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:104142822G>A	uc001tjw.2	+	59	6512	c.6326G>A	c.(6325-6327)AGC>AAC	p.S2109N	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2109	Extracellular (Potential).|EGF-like 16.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTCTCCTGCAGCTGCCAGAAG	0.587													0	0	0	1	0	22	62										A	104142822	G	A	104142822	3	1	100	1	0	0	0	0	1	0	0	0	15237	971	34	2	6560	2	STAB2	12	104142822	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	93490	104142822	29709073	535	31129										
RIC8B	55188	broad.mit.edu	37	chr12	107209010	107209010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctcctctctcacctcaggaGacagactgtgccattgaggc	9	15	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:107209010G>C	uc001tlx.2	+	3	794	c.669G>C	c.(667-669)GAG>GAC	p.E223D	RIC8B_uc001tlw.2_Missense_Mutation_p.E223D|RIC8B_uc001tly.2_Missense_Mutation_p.E183D|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	223					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						CACCTCAGGAGACAGACTGTG	0.478													0	0	0	1	0	47	72										C	107209010	G	C	107209010	3	2	100	1	0	0	0	0	1	0	0	0	13356	933	33	1	679	1	RIC8B	12	107209010	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3066188	107209010	26642885	536	31130										
WSCD2	9671	broad.mit.edu	37	chr12	108603968	108603968	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acaagatccaggcgacgaacGtgagcgaggcagagtgcgac	15	10	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:108603968G>T	uc001tms.2	+	4	1312	c.568G>T	c.(568-570)GTG>TTG	p.V190L	WSCD2_uc001tmt.2_Missense_Mutation_p.V190L	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	190	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GGCGACGAACGTGAGCGAGGC	0.672													1	0	0.115264	1	0.115264	3	24										T	108603968	G	T	108603968	3	4	100	1	0	0	0	0	1	0	0	0	17404	1145	40	4	578	4	WSCD2	12	108603968	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1394958	108603968	25247927	537	31131										
WSB2	55884	broad.mit.edu	37	chr12	118476129	118476129	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagagcacagcatgctgcaGtctggggagatggaacagca	15	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:118476129G>C	uc001twr.2	-	5	722	c.624C>G	c.(622-624)GAC>GAG	p.D208E	WSB2_uc010sza.1_Intron|WSB2_uc010szb.1_5'UTR|WSB2_uc009zws.1_Missense_Mutation_p.D208E	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	208	WD 3.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCATGCTGCAGTCTGGGGAGA	0.512													0	0	0	1	0	14	25										C	118476129	G	C	118476129	3	2	100	1	0	0	0	0	1	0	0	0	17402	1020	36	4	610	4	WSB2	12	118476129	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9872161	118476129	15375766	538	31132										
SRRM4	84530	broad.mit.edu	37	chr12	119559877	119559877	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaccatttcttgtttagctCctctagcccaaaaagcaaaa	5	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:119559877C>A	uc001txa.1	+	6	759	c.467C>A	c.(466-468)TCC>TAC	p.S156Y		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	156	Ser-rich.|Lys-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						TTGTTTAGCTCCTCTAGCCCA	0.378													1	0	0.000151284	1	0.000155097	12	28										A	119559877	C	A	119559877	3	1	100	1	0	0	0	0	1	0	0	0	15170	855	30	3	489	3	SRRM4	12	119559877	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1083748	119559877	14292018	539	31133										
GCN1L1	10985	broad.mit.edu	37	chr12	120576567	120576567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatggtggaatgcagctgctCgaaagtcttggctgccgcct	14	10	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:120576567C>T	uc001txo.2	-	46	6101	c.6088G>A	c.(6088-6090)GAG>AAG	p.E2030K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2030	HEAT 17.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCAGCTGCTCGAAAGTCTTG	0.547													0	0	0	1	0	28	102										T	120576567	C	T	120576567	3	4	100	1	0	0	0	0	1	0	0	0	6299	893	31	1	1979	1	GCN1L1	12	120576567	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1016690	120576567	13275328	540	31134										
PLA2G1B	5319	broad.mit.edu	37	chr12	120759997	120759997	+	Nonstop_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcttttgagaggtgatattCaactctgacaatacttcttg	8	7	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:120759997C>A	uc001tyd.2	-	4	482	c.446G>T	c.(445-447)TGA>TTA	p.*149L	PLA2G1B_uc009zwx.2_3'UTR	NM_000928	NP_000919	P04054	PA21B_HUMAN	phospholipase A2 group IB precursor	149					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of DNA replication|positive regulation of immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			skin(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGTGATATTCAACTCTGACA	0.423													1	0	7.82978e-24	1	8.78906e-24	62	181										A	120759997	C	A	120759997	4	1	100	1	0	0	0	0	0	0	0	0	11994	837	29	3	4	3	PLA2G1B	12	120759997	Nonstop_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	183430	120759997	13091898	541	31135										
POP5	51367	broad.mit.edu	37	chr12	121018922	121018922	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagcgcccttgcacccgcGaagccgatggagcaggcggc	14	17	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:121018922G>A	uc001tys.2	-	2	191	c.159C>T	c.(157-159)TTC>TTT	p.F53F	POP5_uc001tyt.2_Silent_p.F53F	NM_015918	NP_057002	Q969H6	POP5_HUMAN	processing of precursor 5 isoform a	53					tRNA processing		protein binding|ribonuclease P activity				0	all_neural(191;0.077)|Medulloblastoma(191;0.0922)					TTGCACCCGCGAAGCCGATGG	0.677													0	0	0	1	0	11	61										A	121018922	G	A	121018922	2	1	100	1	0	0	0	0	0	0	0	1	12253	1049	37	1		1	POP5	12	121018922	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	258925	121018922	12832973	542	31136										
WDR66	144406	broad.mit.edu	37	chr12	122392093	122392093	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaatttaacacaaatactctCagccacaatggaagggaagc	8	9	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:122392093C>T	uc009zxk.2	+	10	1530	c.1388C>T	c.(1387-1389)TCA>TTA	p.S463L		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	463	WD 4.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAAATACTCTCAGCCACAATG	0.438													0	0	0	1	0	36	69										T	122392093	C	T	122392093	3	4	100	1	0	0	0	0	1	0	0	0	17314	838	29	1	1422	1	WDR66	12	122392093	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1373171	122392093	11459802	543	31137										
VPS33A	65082	broad.mit.edu	37	chr12	122750907	122750907	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagctcgcgacgcaccgcctCgcgcaacacgtttaggttca	10	16	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:122750907C>T	uc001ucd.2	-	1	162	c.49G>A	c.(49-51)GAG>AAG	p.E17K	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Missense_Mutation_p.E17K	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	17					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CGCACCGCCTCGCGCAACACG	0.677													0	0	0	1	0	8	36										T	122750907	C	T	122750907	3	4	100	1	0	0	0	0	1	0	0	0	17198	893	31	1	1793	1	VPS33A	12	122750907	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	358814	122750907	11100988	544	31138										
CLIP1	6249	broad.mit.edu	37	chr12	122825453	122825453	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcttttcttcagtagccttGagctgtgatgtaaaattatc	8	7	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:122825453G>C	uc001ucg.1	-	10	2404	c.2298C>G	c.(2296-2298)CTC>CTG	p.L766L	CLIP1_uc001uch.1_Silent_p.L755L|CLIP1_uc001uci.1_Silent_p.L720L|CLIP1_uc001ucj.1_Intron	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	766	Potential.			L -> P (in Ref. 3; AAI14214).	mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CAGTAGCCTTGAGCTGTGATG	0.408													0	0	0	1	0	52	108										C	122825453	G	C	122825453	2	2	100	1	0	0	0	0	0	0	0	1	3532	1277	45	1		1	CLIP1	12	122825453	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	74546	122825453	11026442	545	31139										
DNAH10	196385	broad.mit.edu	37	chr12	124315201	124315201	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacaaacacacagatgttctCaatgagattgtcacagcagc	7	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:124315201C>A	uc001uft.3	+	25	4171	c.4146C>A	c.(4144-4146)CTC>CTA	p.L1382L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1382	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGATGTTCTCAATGAGATTG	0.368													1	0	7.93312e-07	1	8.29186e-07	13	19										A	124315201	C	A	124315201	2	1	100	1	0	0	0	0	0	0	0	1	4598	813	29	3		3	DNAH10	12	124315201	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1489748	124315201	9536694	546	31140										
SCARB1	949	broad.mit.edu	37	chr12	125284769	125284769	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcgttgaggaagtgaggatgGgagagaaacaagggggcacc	19	5	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:125284769G>T	uc001ugo.3	-	8	1282	c.1029C>A	c.(1027-1029)TCC>TCA	p.S343S	SCARB1_uc001ugn.3_Silent_p.S343S|SCARB1_uc001ugm.3_Silent_p.S343S|SCARB1_uc010tbd.1_Silent_p.S343S|SCARB1_uc010tbe.1_Silent_p.S302S|SCARB1_uc001ugp.3_Silent_p.S343S	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	343	Extracellular (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	AGTGAGGATGGGAGAGAAACA	0.602													1	0	5.16669e-11	1	5.56034e-11	11	32										T	125284769	G	T	125284769	2	4	100	1	0	0	0	0	0	0	0	1	13881	1219	43	4		4	SCARB1	12	125284769	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	969568	125284769	8567126	547	31141										
TPTE2	93492	broad.mit.edu	37	chr13	20006667	20006667	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagtatccgtcttggagggaGattccagttgtagagatgtt	14	5	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:20006667G>C	uc001umd.2	-	17	1379	c.1168C>G	c.(1168-1170)CTC>GTC	p.L390V	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.L279V|TPTE2_uc001ume.2_Missense_Mutation_p.L313V|TPTE2_uc009zzm.2_Missense_Mutation_p.L61V|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Missense_Mutation_p.L61V	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	390						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CTTGGAGGGAGATTCCAGTTG	0.358													0	0	0	1	0	6	24										C	20006667	G	C	20006667	3	2	100	1	0	0	0	0	1	0	0	0	16428	942	33	1	420	1	TPTE2	13	20006667	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		20006667	95163211	548	31142										
SACS	26278	broad.mit.edu	37	chr13	23930039	23930039	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaaagttcactaatttcttTgctgtcatctttgagattcc	6	8	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:23930039T>C	uc001uon.2	-	8	1301	c.712A>G	c.(712-714)AAA>GAA	p.K238E	SACS_uc001uoo.2_Missense_Mutation_p.K91E|SACS_uc001uop.1_Missense_Mutation_p.K25E|SACS_uc001uoq.1_Missense_Mutation_p.K91E	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	238					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTAATTTCTTTGCTGTCATCT	0.388													0	0	0	1	0	63	3										C	23930039	T	C	23930039	3	2	100	1	0	0	0	0	1	0	0	0	13804	1821	63	5	13039	5	SACS	13	23930039	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	3923372	23930039	91239839	549	31143										
FAM123A	219287	broad.mit.edu	37	chr13	25745097	25745097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggtaggatcaagccgccccCgggcgcgcgcccctccgcgg	16	18	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:25745097C>T	uc001uqb.2	-	1	761	c.661G>A	c.(661-663)GGG>AGG	p.G221R	FAM123A_uc001uqa.2_Missense_Mutation_p.G221R|FAM123A_uc001uqc.2_Missense_Mutation_p.G221R	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	221										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAgccgcccccgggcgcgcgc	0.582													0	0	0	1	0	7	1										T	25745097	C	T	25745097	3	4	100	1	0	0	0	0	1	0	0	0	5422	652	23	2	1358	2	FAM123A	13	25745097	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1815058	25745097	89424781	550	31144										
KBTBD7	84078	broad.mit.edu	37	chr13	41766848	41766848	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	attgaagacacatgcttcctGaaagtcactacgtttaagag	8	8	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:41766848G>A	uc001uxw.1	-	1	1855	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	516	Kelch 3.						protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		CATGCTTCCTGAAAGTCACTA	0.428													0	0	0	1	0	82	11										A	41766848	G	A	41766848	4	1	100	1	0	0	0	0	0	1	0	0	7998	1299	45	1	512	1	KBTBD7	13	41766848	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	16021751	41766848	73403030	551	31145										
C13orf18	80183	broad.mit.edu	37	chr13	46946326	46946326	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtctctgccagggagtccccGaggcacgaaggtgaagggcc	16	12	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:46946326G>A	uc010acl.2	-	3	890	c.285C>T	c.(283-285)CTC>CTT	p.L95L	C13orf18_uc001vbf.3_Silent_p.L28L|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_5'UTR|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Silent_p.L95L|C13orf18_uc001vbh.3_Silent_p.L95L|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Silent_p.L95L|C13orf18_uc010tga.1_Silent_p.L28L	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	95	Ser-rich.										0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		GGGAGTCCCCGAGGCACGAAG	0.582													0	0	0	1	0	12	35										A	46946326	G	A	46946326	2	1	100	1	0	0	0	0	0	0	0	1	1720	1045	37	1		1	C13orf18	13	46946326	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5179478	46946326	68223552	552	31146										
PCDH17	27253	broad.mit.edu	37	chr13	58207298	58207298	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctctggaccgcgagcaacaGaatcaccatacgctcgtgct	10	14	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:58207298G>A	uc001vhq.1	+	1	1510	c.618G>A	c.(616-618)CAG>CAA	p.Q206Q	PCDH17_uc010aec.1_Silent_p.Q206Q	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	206	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCGAGCAACAGAATCACCATA	0.592													0	0	0	1	0	14	21										A	58207298	G	A	58207298	2	1	100	1	0	0	0	0	0	0	0	1	11512	933	33	1		1	PCDH17	13	58207298	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	11260972	58207298	56962580	553	31147										
OXGR1	27199	broad.mit.edu	37	chr13	97639537	97639537	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgacagctaccagtgaaatGatccacaccacagcacaggc	8	13	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:97639537G>A	uc001vmx.1	-	4	721	c.477C>T	c.(475-477)ATC>ATT	p.I159I	OXGR1_uc010afr.1_Silent_p.I159I	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	159	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			CCAGTGAAATGATCCACACCA	0.478													0	0	0	1	0	4	46										A	97639537	G	A	97639537	2	1	100	1	0	0	0	0	0	0	0	1	11332	1280	45	1		1	OXGR1	13	97639537	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	39432239	97639537	17530341	554	31148										
MBNL2	10150	broad.mit.edu	37	chr13	98043621	98043621	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggaatggaatgccaagaatCtgcattgagaataactaaac	9	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:98043621C>T	uc010aft.2	+	8	1856	c.1040C>T	c.(1039-1041)TCT>TTT	p.S347F	MBNL2_uc001vmz.2_3'UTR|MBNL2_uc001vna.2_Missense_Mutation_p.S335F|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Missense_Mutation_p.S180F	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	347					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			TGCCAAGAATCTGCATTGAGA	0.343													0	0	0	1	0	30	56										T	98043621	C	T	98043621	3	4	100	1	0	0	0	0	1	0	0	0	9354	913	32	1	1165	1	MBNL2	13	98043621	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	404084	98043621	17126257	555	31149										
DOCK9	23348	broad.mit.edu	37	chr13	99537285	99537285	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggaaggttcgccgagaccggGatgtgctgctcgcttgtcac	15	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:99537285G>A	uc001vnt.2	-	21	2380	c.2325C>T	c.(2323-2325)ATC>ATT	p.I775I	DOCK9_uc001vnw.2_Silent_p.I774I|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.I775I|DOCK9_uc010tis.1_Silent_p.I774I|DOCK9_uc010tit.1_Silent_p.I775I|DOCK9_uc010afu.1_Silent_p.I621I	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	775	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCGAGACCGGGATGTGCTGCT	0.512													0	0	0	1	0	10	9										A	99537285	G	A	99537285	2	1	100	1	0	0	0	0	0	0	0	1	4694	1164	41	1		1	DOCK9	13	99537285	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1493664	99537285	15632593	556	31150										
CLYBL	171425	broad.mit.edu	37	chr13	100518572	100518572	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catagcgaaagcctttggtcTccaagccatagatctggtgt	10	10	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:100518572T>C	uc001vok.2	+	6	727	c.713T>C	c.(712-714)CTC>CCC	p.L238P	CLYBL_uc010tix.1_3'UTR|CLYBL_uc010tiy.1_Missense_Mutation_p.L204P	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	238					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCCTTTGGTCTCCAAGCCATA	0.473													0	0	0	1	0	21	67										C	100518572	T	C	100518572	3	2	100	1	0	0	0	0	1	0	0	0	3573	1551	54	5	735	5	CLYBL	13	100518572	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	981287	100518572	14651306	557	31151										
NALCN	259232	broad.mit.edu	37	chr13	102051408	102051408	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgtcagcattatccgacaGagactcatcaggaccaaagt	9	10	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:102051408G>A	uc001vox.1	-	2	259	c.70C>T	c.(70-72)CTG>TTG	p.L24L	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Silent_p.L24L|NALCN_uc001vpa.2_Silent_p.L24L	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	24	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTATCCGACAGAGACTCATCA	0.443													0	0	0	1	0	24	44										A	102051408	G	A	102051408	2	1	100	1	0	0	0	0	0	0	0	1	10148	933	33	1		1	NALCN	13	102051408	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1532836	102051408	13118470	558	31152										
SLC10A2	6555	broad.mit.edu	37	chr13	103718286	103718286	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggcagttcctccagggcagCatcctataatgagcaccact	9	13	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:103718286C>T	uc001vpy.3	-	1	911	c.314G>A	c.(313-315)TGC>TAC	p.C105Y		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	105	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TCCAGGGCAGCATCCTATAAT	0.512													0	0	0	1	0	67	6										T	103718286	C	T	103718286	3	4	100	1	0	0	0	0	1	0	0	0	14374	710	25	2	756	2	SLC10A2	13	103718286	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1666878	103718286	11451592	559	31153										
TEP1	7011	broad.mit.edu	37	chr14	20856168	20856168	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtggaatcttgaatattttGtccatttggcccacatgttc	9	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:20856168G>C	uc001vxe.2	-	18	2620	c.2580C>G	c.(2578-2580)GAC>GAG	p.D860E	TEP1_uc010ahk.2_Missense_Mutation_p.D210E|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.D752E	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	860					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGAATATTTTGTCCATTTGGC	0.507													0	0	0	1	0	14	18										C	20856168	G	C	20856168	3	2	100	1	0	0	0	0	1	0	0	0	15756	1368	48	4	5455	4	TEP1	14	20856168	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		20856168	86493372	560	31154										
RNF31	55072	broad.mit.edu	37	chr14	24617000	24617001	+	Missense_Mutation	DNP	GG	GG	AA													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccgggcaggcgttttccctGgagcagctccggccgctact							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24617000_24617001GG>AA	uc001wmn.1	+	1	342_343	c.93_94GG>AA	c.(91-96)CTGGAG>CTAAAG	p.E32K	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Intron|RNF31_uc001wmm.1_RNA|RNF31_uc010alg.1_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	32	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CGTTTTCCCTGGAGCAGCTCCG	0.703													0	0	0	1	0	2	0										AA	24617001	GG	AA	24617000	3	1	100	1	0	0	0	0	1	0	0	0	13487	1335	47	2	95	2	RNF31	14	24617000	Missense_Mutation	DNP	GG	TCGA-G2-A3VY-01A-11D-A22Z-08	3760832	24617000	82732540	561	31155			2	136		4	4	3039	N	GG_G	8.923968e-05
RNF31	55072	broad.mit.edu	37	chr14	24619469	24619469	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggggttggggttgggaactGagggtccccaaggaactgga	19	6	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24619469G>A	uc001wmn.1	+	7	1258	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	RNF31_uc001wml.1_Missense_Mutation_p.E186K|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E152K|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	337	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GTTGGGAACTGAGGGTCCCCA	0.602													0	0	0	1	0	36	2										A	24619469	G	A	24619469	3	1	100	1	0	0	0	0	1	0	0	0	13487	1291	45	1	1035	1	RNF31	14	24619469	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2469	24619469	82730071	562	31156			2	136		4	4	3039	N	GG_G	8.923968e-05
RNF31	55072	broad.mit.edu	37	chr14	24619594	24619594	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atatgtgagcgacctcggctGgcccagcctcccagcttggt	12	14	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24619594G>A	uc001wmn.1	+	7	1383	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	RNF31_uc001wml.1_Silent_p.L227L|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Silent_p.L193L|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	378	RanBP2-type 2.|Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GACCTCGGCTGGCCCAGCCTC	0.567													0	0	0	1	0	53	4										A	24619594	G	A	24619594	2	1	100	1	0	0	0	0	0	0	0	1	13487	1335	47	2		2	RNF31	14	24619594	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	125	24619594	82729946	563	31157			2	136		4	4	3039	N	GG_G	8.923968e-05
RNF31	55072	broad.mit.edu	37	chr14	24620038	24620038	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccagttcctgtggagatcctGagaagcagcgccaagacaag	12	11	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24620038G>A	uc001wmn.1	+	8	1678	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K	RNF31_uc001wml.1_Missense_Mutation_p.E326K|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E292K|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	477	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		TGGAGATCCTGAGAAGCAGCG	0.632													0	0	0	1	0	28	1										A	24620038	G	A	24620038	3	1	100	1	0	0	0	0	1	0	0	0	13487	1291	45	1	1459	1	RNF31	14	24620038	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	444	24620038	82729502	564	31158			2	136		4	4	3039	N	GG_G	8.923968e-05
FOXG1	2290	broad.mit.edu	37	chr14	29237037	29237037	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagtacgagaagccgccgttCagctacaacgcgctcatcat	9	13	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:29237037C>G	uc001wqe.2	+	1	751	c.552C>G	c.(550-552)TTC>TTG	p.F184L		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	184	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AGCCGCCGTTCAGCTACAACG	0.353													0	0	0	1	0	20	1										G	29237037	C	G	29237037	3	3	100	1	0	0	0	0	1	0	0	0	6007	825	29	1	554	1	FOXG1	14	29237037	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4616999	29237037	78112503	565	31159										
HECTD1	25831	broad.mit.edu	37	chr14	31598292	31598292	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacgttttcagcagatgaaaGaacaacaattggttcatgga	10	6	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:31598292G>C	uc001wrc.1	-	25	4774	c.4285C>G	c.(4285-4287)CTT>GTT	p.L1429V	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.L897V	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1429	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCAGATGAAAGAACAACAATT	0.453													0	0	0	1	0	36	55										C	31598292	G	C	31598292	3	2	100	1	0	0	0	0	1	0	0	0	7039	942	33	1	3623	1	HECTD1	14	31598292	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2361255	31598292	75751248	566	31160										
AKAP6	9472	broad.mit.edu	37	chr14	33004894	33004908	+	In_Frame_Del	DEL	GCTTCGAGTCTCAGT	GCTTCGAGTCTCAGT	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgcagctcctctggcaccaGcttcgagtctcagtgctggt							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:33004894_33004908delGCTTCGAGTCTCAGT	uc001wrq.2	+	3	629_643	c.459_473delGCTTCGAGTCTCAGT	c.(457-474)CAGCTTCGAGTCTCAGTG>CAG	p.LRVSV154del	AKAP6_uc010aml.2_In_Frame_Del_p.LRVSV151del	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	154_158					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCTGGCACCAGCTTCGAGTCTCAGTGCTGGTTCTG	0.521																		18	40	---	---								-	33004908	GCTTCGAGTCTCAGT	-	33004894	7	5	100	1	0	1	0	1	0	0	0	0	455	962	34	0	465	0	AKAP6	14	33004894	In_Frame_Del	DEL	GCTTCGAGTCTCAGT	TCGA-G2-A3VY-01A-11D-A22Z-08	1406602	33004894	74344646	567	31161										
FANCM	57697	broad.mit.edu	37	chr14	45668041	45668041	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggtgaatagtaataaaagtGaggcactccagttttattta	9	4	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:45668041G>A	uc001wwd.3	+	22	6010	c.5911G>A	c.(5911-5913)GAG>AAG	p.E1971K	FANCM_uc010anf.2_Missense_Mutation_p.E1945K|FANCM_uc001wwe.3_Missense_Mutation_p.E1507K|FANCM_uc010ang.2_Missense_Mutation_p.E1220K	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1971	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TAATAAAAGTGAGGCACTCCA	0.348								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	1	0	31	5										A	45668041	G	A	45668041	3	1	100	1	0	0	0	0	1	0	0	0	5671	1291	45	1	5997	1	FANCM	14	45668041	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	12663147	45668041	61681499	568	31162										
CNIH	10175	broad.mit.edu	37	chr14	54898890	54898890	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagccactctgctgcacaaaGaaacatgacacagaagaaag	8	10	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:54898890G>C	uc001xat.1	-	3	302	c.199C>G	c.(199-201)CTT>GTT	p.L67V	CNIH_uc001xav.1_Missense_Mutation_p.L67V	NM_005776	NP_005767	O95406	CNIH_HUMAN	cornichon-like	67	Helical; (Potential).				immune response|intracellular signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane					0				GBM - Glioblastoma multiforme(112;0.00341)		GCTGCACAAAGAAACATGACA	0.388													0	0	0	1	0	3	2										C	54898890	G	C	54898890	3	2	100	1	0	0	0	0	1	0	0	0	3602	942	33	1	247	1	CNIH	14	54898890	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9230849	54898890	52450650	569	31163										
C14orf149	112849	broad.mit.edu	37	chr14	59950883	59950883	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtgctggcgcatgtagcgcCgcttggccagcagggtgggc	19	11	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:59950883C>T	uc001xee.1	-	1	191	c.152G>A	c.(151-153)CGG>CAG	p.R51Q	C14orf149_uc010trx.1_Missense_Mutation_p.R51Q|JKAMP_uc001xef.3_5'Flank|JKAMP_uc001xeh.3_5'Flank|JKAMP_uc001xeg.3_5'Flank|JKAMP_uc010try.1_5'Flank|JKAMP_uc001xei.3_5'Flank	NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	51							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	CATGTAGCGCCGCTTGGCCAG	0.701											OREG0022712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	6										T	59950883	C	T	59950883	3	4	100	1	0	0	0	0	1	0	0	0	1752	652	23	2	932	2	C14orf149	14	59950883	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5051993	59950883	47398657	570	31164										
PRKCH	5583	broad.mit.edu	37	chr14	61995799	61995799	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttgtatctttcagagatctGaaactggacaatgtcctgtt	8	7	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:61995799G>C	uc001xfn.2	+	11	1745	c.1440G>C	c.(1438-1440)CTG>CTC	p.L480L	PRKCH_uc010tsa.1_Silent_p.L319L|PRKCH_uc010tsb.1_Silent_p.L48L	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	480	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TCAGAGATCTGAAACTGGACA	0.453													0	0	0	1	0	36	2										C	61995799	G	C	61995799	2	2	100	1	0	0	0	0	0	0	0	1	12513	1277	45	1		1	PRKCH	14	61995799	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2044916	61995799	45353741	571	31165										
SYNE2	23224	broad.mit.edu	37	chr14	64467418	64467418	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggaaagagaaagagagcttCagatgactcttaataccagg	11	6	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:64467418C>T	uc001xgm.2	+	28	3849	c.3619C>T	c.(3619-3621)CAG>TAG	p.Q1207*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q1207*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1207	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAGAGAGCTTCAGATGACTCT	0.294													0	0	0	1	0	17	29										T	64467418	C	T	64467418	4	4	100	1	0	0	0	0	0	1	0	0	15443	827	29	1	3725	1	SYNE2	14	64467418	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2471619	64467418	42882122	572	31166										
C14orf45	80127	broad.mit.edu	37	chr14	74514682	74514682	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttaaagagaatgattatcttCagaaagctctggcatatcac	7	7	4	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:74514682C>T	uc010tup.1	+	7	820	c.697C>T	c.(697-699)CAG>TAG	p.Q233*	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	233											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		TGATTATCTTCAGAAAGCTCT	0.363													0	0	0	1	0	12	17										T	74514682	C	T	74514682	4	4	100	1	0	0	0	0	0	1	0	0	1775	827	29	1	723	1	C14orf45	14	74514682	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	10047264	74514682	32834858	573	31167										
KIAA0317	9870	broad.mit.edu	37	chr14	75130693	75130693	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagcctccaggtggtagctGagaggagcctgttgtgaact	14	8	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:75130693G>A	uc001xqb.2	-	19	2783	c.2278C>T	c.(2278-2280)CAG>TAG	p.Q760*	KIAA0317_uc010tut.1_Nonsense_Mutation_p.Q599*	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	760	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		GGTGGTAGCTGAGAGGAGCCT	0.562													0	0	0	1	0	18	44										A	75130693	G	A	75130693	4	1	100	1	0	0	0	0	0	1	0	0	8167	1299	45	1	201	1	KIAA0317	14	75130693	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	616011	75130693	32218847	574	31168										
ISM2	145501	broad.mit.edu	37	chr14	77942212	77942212	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccagtgtgctgctctccccaGacagcatggaacgcaggcag	12	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:77942212G>C	uc001xtz.2	-	7	1516	c.1442C>G	c.(1441-1443)TCT>TGT	p.S481C	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.S393C|ISM2_uc010tvl.1_Missense_Mutation_p.S400C	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	481	AMOP.					extracellular region				skin(1)	1						GCTCTCCCCAGACAGCATGGA	0.687													0	0	0	1	0	5	40										C	77942212	G	C	77942212	3	2	100	1	0	0	0	0	1	0	0	0	7861	942	33	1	277	1	ISM2	14	77942212	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2811519	77942212	29407328	575	31169										
DIO2	1734	broad.mit.edu	37	chr14	80677657	80677657	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtccctctgaggtcagcatGcgccgccactctccgcgagt	11	16	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:80677657G>A	uc010tvq.1	-	2	561	c.159C>T	c.(157-159)CGC>CGT	p.R53R	uc001xuw.1_5'Flank|DIO2_uc010tvp.1_Silent_p.R53R|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_Silent_p.R53R|DIO2_uc010tvr.1_Silent_p.R53R|DIO2_uc010asy.2_Silent_p.R53R	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	53					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		AGGTCAGCATGCGCCGCCACT	0.592													0	0	0	1	0	16	16										A	80677657	G	A	80677657	2	1	100	1	0	0	0	0	0	0	0	1	4525	1306	46	2		2	DIO2	14	80677657	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2735445	80677657	26671883	576	31170										
FOXN3	1112	broad.mit.edu	37	chr14	89817116	89817116	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aattagattttgtctatactCtgggtctatgcaccacaacg	7	9	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:89817116C>G	uc001xxo.3	-	3	717	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	FOXN3_uc001xxn.3_Missense_Mutation_p.E194Q|FOXN3_uc010atk.2_Missense_Mutation_p.E194Q	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	194	Fork-head.				DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						TGTCTATACTCTGGGTCTATG	0.388													0	0	0	1	0	26	54										G	89817116	C	G	89817116	3	3	100	1	0	0	0	0	1	0	0	0	6021	922	32	1	912	1	FOXN3	14	89817116	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9139459	89817116	17532424	577	31171										
RPS6KA5	9252	broad.mit.edu	37	chr14	91367073	91367073	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggatggaaggagcaacaaagGaatagccctaaaaacaagac	11	7	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:91367073G>C	uc001xys.2	-	10	1342	c.1127C>G	c.(1126-1128)TCC>TGC	p.S376C	RPS6KA5_uc010twi.1_Missense_Mutation_p.S297C|RPS6KA5_uc001xyt.2_Missense_Mutation_p.S376C|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	376	AGC-kinase C-terminal.			S->A: Loss of kinase activity, and decreases the phosphorylation of S-360 and T-581.	axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AGCAACAAAGGAATAGCCCTA	0.378													0	0	0	1	0	11	17										C	91367073	G	C	91367073	3	2	100	1	0	0	0	0	1	0	0	0	13654	1174	41	1	1319	1	RPS6KA5	14	91367073	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1549957	91367073	15982467	578	31172										
TC2N	123036	broad.mit.edu	37	chr14	92253884	92253884	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagaggtgttgatgagcttgGaaggtaccgtgcctcaagaa	14	7	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:92253884G>T	uc001xzu.3	-	10	1326	c.1135C>A	c.(1135-1137)CCA>ACA	p.P379T	TC2N_uc001xzt.3_Missense_Mutation_p.P379T|TC2N_uc010auc.2_Missense_Mutation_p.P315T|TC2N_uc001xzv.3_Missense_Mutation_p.P379T	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	379	C2.					nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		GATGAGCTTGGAAGGTACCGT	0.348													1	0	3.09899e-07	1	3.2626e-07	9	31										T	92253884	G	T	92253884	3	4	100	1	0	0	0	0	1	0	0	0	15662	1174	41	3	349	3	TC2N	14	92253884	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	886811	92253884	15095656	579	31173										
TC2N	123036	broad.mit.edu	37	chr14	92253914	92253914	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcctcaagaatttgtaactGaattctgctatttactgctt	6	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:92253914G>C	uc001xzu.3	-	10	1296	c.1105C>G	c.(1105-1107)CAG>GAG	p.Q369E	TC2N_uc001xzt.3_Missense_Mutation_p.Q369E|TC2N_uc010auc.2_Missense_Mutation_p.Q305E|TC2N_uc001xzv.3_Missense_Mutation_p.Q369E	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	369	C2.					nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		ATTTGTAACTGAATTCTGCTA	0.363													0	0	0	1	0	12	37										C	92253914	G	C	92253914	3	2	100	1	0	0	0	0	1	0	0	0	15662	1299	45	1	379	1	TC2N	14	92253914	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	30	92253914	15095626	580	31174										
SERPINA3	12	broad.mit.edu	37	chr14	95080891	95080891	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggagaatctgacccaggagaAccaagaccgagggacacacg	13	11	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:95080891A>C	uc001ydp.2	+	2	192	c.113A>C	c.(112-114)AAC>ACC	p.N38T	SERPINA3_uc001ydo.3_Missense_Mutation_p.N63T|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.N38T|SERPINA3_uc001yds.2_Missense_Mutation_p.N38T|SERPINA3_uc010avg.2_Missense_Mutation_p.N38T	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	38					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		ACCCAGGAGAACCAAGACCGA	0.587													0	0	0	1	0	28	71										C	95080891	A	C	95080891	3	2	100	1	0	0	0	0	1	0	0	0	14090	43	2	5	115	5	SERPINA3	14	95080891	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	2826977	95080891	12268649	581	31175										
DICER1	23405	broad.mit.edu	37	chr14	95570291	95570291	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgcagttcacagacatttGgtcatgattttctagagagg	10	7	4	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:95570291G>C	uc001ydw.2	-	22	3624	c.3442C>G	c.(3442-3444)CAA>GAA	p.Q1148E	DICER1_uc010avh.1_Missense_Mutation_p.Q46E|DICER1_uc001ydv.2_Missense_Mutation_p.Q1138E|DICER1_uc001ydx.2_Missense_Mutation_p.Q1148E|DICER1_uc001ydy.1_5'UTR	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1148					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		ACAGACATTTGGTCATGATTT	0.418			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	1	0	36	18										C	95570291	G	C	95570291	3	2	100	1	0	0	0	0	1	0	0	0	4521	1357	47	4	2354	4	DICER1	14	95570291	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	489400	95570291	11779249	582	31176										
CCNK	8812	broad.mit.edu	37	chr14	99959910	99959910	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgcttctatatgtttcattCcttcaagcaattcccaagat	4	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:99959910C>T	uc001ygi.3	+	3	387	c.257C>T	c.(256-258)TCC>TTC	p.S86F	CCNK_uc001ygg.3_Missense_Mutation_p.S86F	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	86					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				ATGTTTCATTCCTTCAAGCAA	0.328													0	0	0	1	0	13	14										T	99959910	C	T	99959910	3	4	100	1	0	0	0	0	1	0	0	0	2930	855	30	1	263	1	CCNK	14	99959910	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4389619	99959910	7389630	583	31177										
ASPG	374569	broad.mit.edu	37	chr14	104552129	104552129	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggcgcgcgcggtggggcccGagcggaggctgctggccgtc	21	13	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:104552129G>T	uc001yoq.1	+	1	82	c.22G>T	c.(22-24)GAG>TAG	p.E8*	ASPG_uc001yoo.1_5'UTR|ASPG_uc001yop.1_Nonsense_Mutation_p.E8*|ASPG_uc001yor.1_Nonsense_Mutation_p.E8*	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	8					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GGTGGGGCCCGAGCGGAGGCT	0.746													1	0	1.12685e-05	1	1.16464e-05	9	5										T	104552129	G	T	104552129	4	4	100	1	0	0	0	0	0	1	0	0	1052	1059	37	3	24	3	ASPG	14	104552129	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4592219	104552129	2797411	584	31178										
AHNAK2	113146	broad.mit.edu	37	chr14	105410361	105410361	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacaccccaaatgacggcatCttgaacttgggcattttgaa	9	10	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:105410361C>G	uc010axc.1	-	7	11547	c.11427G>C	c.(11425-11427)AAG>AAC	p.K3809N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K3709N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3809						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATGACGGCATCTTGAACTTGG	0.572													0	0	0	1	0	94	204										G	105410361	C	G	105410361	3	3	100	1	0	0	0	0	1	0	0	0	415	912	32	1	5964	1	AHNAK2	14	105410361	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	858232	105410361	1939179	585	31179										
CRIP1	1396	broad.mit.edu	37	chr14	105954549	105954549	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gactggcatcggccctgcctGaagtgcgagaaatgtgggaa	15	9	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:105954549G>A	uc001yri.3	+	3	201	c.87G>A	c.(85-87)CTG>CTA	p.L29L	C14orf80_uc001yrj.2_5'Flank|C14orf80_uc001yrk.2_5'Flank	NM_001311	NP_001302	P50238	CRIP1_HUMAN	cysteine-rich protein 1 (intestinal)	29	LIM zinc-binding.				cell proliferation	cytoplasm	zinc ion binding				0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.235)		GGCCCTGCCTGAAGTGCGAGA	0.682													0	0	0	1	0	18	33										A	105954549	G	A	105954549	2	1	100	1	0	0	0	0	0	0	0	1	3874	1277	45	1		1	CRIP1	14	105954549	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	544188	105954549	1394991	586	31180										
CYFIP1	23191	broad.mit.edu	37	chr15	22993125	22993125	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgggaggtggggaacgccatCctcttctgcctgctcatcga	13	13	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:22993125C>T	uc001yus.2	+	26	3116	c.3012C>T	c.(3010-3012)ATC>ATT	p.I1004I	CYFIP1_uc001yut.2_Silent_p.I1004I|CYFIP1_uc010aya.1_Silent_p.I1032I|CYFIP1_uc001yuu.2_Silent_p.I573I|CYFIP1_uc001yuv.2_Silent_p.I198I	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	1004					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGAACGCCATCCTCTTCTGCC	0.498													0	0	0	1	0	41	23										T	22993125	C	T	22993125	2	4	100	1	0	0	0	0	0	0	0	1	4137	845	30	1		1	CYFIP1	15	22993125	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		22993125	79538267	587	31181										
HERC2	8924	broad.mit.edu	37	chr15	28377404	28377404	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acggtggccctgcagcgcctCcaccttcagagaaaagggac	12	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:28377404C>G	uc001zbj.2	-	81	12518	c.12412G>C	c.(12412-12414)GAG>CAG	p.E4138Q		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4138	RCC1 16.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGCAGCGCCTCCACCTTCAGA	0.567													0	0	0	1	0	3	14										G	28377404	C	G	28377404	3	3	100	1	0	0	0	0	1	0	0	0	7058	864	30	1	2144	1	HERC2	15	28377404	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5384279	28377404	74153988	588	31182										
TRPM1	4308	broad.mit.edu	37	chr15	31352839	31352839	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagctgatctggagcagataCgtttgttcctggaaaggcaa	12	8	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:31352839C>G	uc001zfm.2	-	10	1233	c.1105G>C	c.(1105-1107)GTA>CTA	p.V369L	TRPM1_uc010azy.2_Missense_Mutation_p.V276L|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	369	Extracellular (Potential).			V -> L (in Ref. 2; BAC80200).	cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGAGCAGATACGTTTGTTCCT	0.562													0	0	0	1	0	6	11										G	31352839	C	G	31352839	3	3	100	1	0	0	0	0	1	0	0	0	16582	536	19	4	3778	4	TRPM1	15	31352839	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2975435	31352839	71178553	589	31183										
RYR3	6263	broad.mit.edu	37	chr15	33961642	33961642	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtatgatttccatgaggacCttctccttcactgtggtaag	9	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:33961642C>T	uc001zhi.2	+	37	5777	c.5707C>T	c.(5707-5709)CTT>TTT	p.L1903F	RYR3_uc010bar.2_Missense_Mutation_p.L1903F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1903	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCATGAGGACCTTCTCCTTCA	0.458													0	0	0	1	0	20	13										T	33961642	C	T	33961642	3	4	100	1	0	0	0	0	1	0	0	0	13770	681	24	2	5853	2	RYR3	15	33961642	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2608803	33961642	68569750	590	31184										
RYR3	6263	broad.mit.edu	37	chr15	33988667	33988667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcaggatgggcaaggaagagGagttgctcatgatcaatggg	16	5	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:33988667G>A	uc001zhi.2	+	39	6179	c.6109G>A	c.(6109-6111)GAG>AAG	p.E2037K	RYR3_uc010bar.2_Missense_Mutation_p.E2037K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2037	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAAGGAAGAGGAGTTGCTCAT	0.522													0	0	0	1	0	20	15										A	33988667	G	A	33988667	3	1	100	1	0	0	0	0	1	0	0	0	13770	1175	41	1	6263	1	RYR3	15	33988667	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	27025	33988667	68542725	591	31185										
RYR3	6263	broad.mit.edu	37	chr15	34113731	34113731	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcaccatggcaggtgagatGagccccatggtggttgagac	14	9	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:34113731G>A	uc001zhi.2	+	80	10993	c.10923G>A	c.(10921-10923)ATG>ATA	p.M3641I	RYR3_uc010bar.2_Missense_Mutation_p.M3636I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3641					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGGTGAGATGAGCCCCATGG	0.527													0	0	0	1	0	11	29										A	34113731	G	A	34113731	3	1	100	1	0	0	0	0	1	0	0	0	13770	1290	45	1	11241	1	RYR3	15	34113731	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	125064	34113731	68417661	592	31186										
C15orf55	256646	broad.mit.edu	37	chr15	34647761	34647761	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccaagtttcagtggcgctCagttggactcaagtccttct	9	12	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:34647761C>T	uc001zif.2	+	7	1623	c.1468C>T	c.(1468-1470)CAG>TAG	p.Q490*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.Q518*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.Q508*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	490						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CAGTGGCGCTCAGTTGGACTC	0.572			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	1	0	17	48										T	34647761	C	T	34647761	4	4	100	1	0	0	0	0	0	1	0	0	1803	827	29	1	1494	1	C15orf55	15	34647761	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	534030	34647761	67883631	593	31187										
SPRED1	161742	broad.mit.edu	37	chr15	38614540	38614540	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacaagaagtttggtcttacGtttcaaagtcctgctgatgc	10	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:38614540G>T	uc001zka.3	+	3	641	c.306G>T	c.(304-306)ACG>ACT	p.T102T		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	102	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TTGGTCTTACGTTTCAAAGTC	0.363									Legius_syndrome				1	0	1.67942e-08	1	1.77359e-08	17	76										T	38614540	G	T	38614540	2	4	100	1	0	0	0	0	0	0	0	1	15091	1132	40	4		4	SPRED1	15	38614540	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3966779	38614540	63916852	594	31188										
C15orf52	388115	broad.mit.edu	37	chr15	40632197	40632197	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctcctgcctgctcatggggGactcggctctgggagttccc	13	14	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:40632197G>A	uc001zlh.3	-	2	180	c.164C>T	c.(163-165)TCC>TTC	p.S55F	C15orf52_uc001zli.1_5'UTR|C15orf52_uc010ucn.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	55										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCTCATGGGGGACTCGGCTCT	0.612													0	0	0	1	0	18	9										A	40632197	G	A	40632197	3	1	100	1	0	0	0	0	1	0	0	0	1800	1174	41	1	1480	1	C15orf52	15	40632197	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2017657	40632197	61899195	595	31189										
SPTBN5	51332	broad.mit.edu	37	chr15	42178522	42178522	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtcagccaccagctgctcgtActgggtctgcagcagctctg	12	14	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:42178522A>G	uc001zos.2	-	7	1159	c.826T>C	c.(826-828)TAC>CAC	p.Y276H		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	311	Spectrin 1.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		AGCTGCTCGTACTGGGTCTGC	0.622													0	0	0	1	0	3	18										G	42178522	A	G	42178522	3	3	100	1	0	0	0	0	1	0	0	0	15121	391	14	5	10341	5	SPTBN5	15	42178522	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1546325	42178522	60352870	596	31190										
PLA2G4D	283748	broad.mit.edu	37	chr15	42364006	42364006	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atccggggctccgggatcctCctcatcagccgtcccatgaa	10	16	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:42364006C>A	uc001zox.2	-	15	1634	c.1539G>T	c.(1537-1539)AGG>AGT	p.R513S		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	513	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CCGGGATCCTCCTCATCAGCC	0.617													1	0	9.05144e-12	1	9.79289e-12	14	34										A	42364006	C	A	42364006	3	1	100	1	0	0	0	0	1	0	0	0	12004	854	30	3	941	3	PLA2G4D	15	42364006	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	185484	42364006	60167386	597	31191										
CDAN1	146059	broad.mit.edu	37	chr15	43018340	43018340	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcactttgccagatgctgctCagcaggtgggcacaggaact	13	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:43018340C>A	uc001zql.2	-	25	3340	c.3223G>T	c.(3223-3225)GAG>TAG	p.E1075*	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Nonsense_Mutation_p.E401*	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	1075						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		AGATGCTGCTCAGCAGGTGGG	0.562													1	0	1.12685e-05	1	1.16464e-05	8	31										A	43018340	C	A	43018340	4	1	100	1	0	0	0	0	0	1	0	0	3054	835	29	3	476	3	CDAN1	15	43018340	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	654334	43018340	59513052	598	31192										
TUBGCP4	27229	broad.mit.edu	37	chr15	43675567	43675567	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggatgctccatggactcctCttggaccagcatgaagaatt	10	10	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:43675567C>G	uc001zro.2	+	7	828	c.588C>G	c.(586-588)CTC>CTG	p.L196L	TUBGCP4_uc001zrn.2_Silent_p.L196L|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	196					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		ATGGACTCCTCTTGGACCAGC	0.517													0	0	0	1	0	21	34										G	43675567	C	G	43675567	2	3	100	1	0	0	0	0	0	0	0	1	16765	900	32	1		1	TUBGCP4	15	43675567	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	657227	43675567	58855825	599	31193										
FBN1	2200	broad.mit.edu	37	chr15	48703211	48703211	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaagcaaaacctggattttCatcttcagattatcacccag	6	10	4	2	rs139679866		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:48703211C>G	uc001zwx.1	-	66	8920	c.8592G>C	c.(8590-8592)ATG>ATC	p.M2864I	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2864					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCTGGATTTTCATCTTCAGAT	0.328													0	0	0	1	0	11	34										G	48703211	C	G	48703211	3	3	100	1	0	0	0	0	1	0	0	0	5702	826	29	1	27	1	FBN1	15	48703211	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5027644	48703211	53828181	600	31194										
COPS2	9318	broad.mit.edu	37	chr15	49437194	49437194	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcttaatgccgcttttgggtCatcttcttttaatgctttgg	9	8	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:49437194C>T	uc001zxf.2	-	2	215	c.136G>A	c.(136-138)GAC>AAC	p.D46N	COPS2_uc001zxh.2_Missense_Mutation_p.D46N|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	46					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		GCTTTTGGGTCATCTTCTTTT	0.323													0	0	0	1	0	27	33										T	49437194	C	T	49437194	3	4	100	1	0	0	0	0	1	0	0	0	3733	826	29	1	1264	1	COPS2	15	49437194	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	733983	49437194	53094198	601	31195										
GLDN	342035	broad.mit.edu	37	chr15	51634220	51634220	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagagccatgacatgctgatGatgatgacctactccatggt	11	9	0	6			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:51634220G>A	uc002aba.2	+	1	508	c.339G>A	c.(337-339)ATG>ATA	p.M113I	GLDN_uc010bez.1_Missense_Mutation_p.M113I	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	113	Extracellular (Potential).				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		ACATGCTGATGATGATGACCT	0.711													0	0	0	1	0	14	37										A	51634220	G	A	51634220	3	1	100	1	0	0	0	0	1	0	0	0	6434	1290	45	1	341	1	GLDN	15	51634220	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2197026	51634220	50897172	602	31196										
DMXL2	23312	broad.mit.edu	37	chr15	51778370	51778370	+	Frame_Shift_Del	DEL	A	A	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcaagactacgcaggaaaggAtcaggatgtaatcttttgca							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:51778370delA	uc002abf.2	-	23	5607	c.5382delT	c.(5380-5382)GATfs	p.D1794fs	DMXL2_uc010ufy.1_Frame_Shift_Del_p.D1794fs|DMXL2_uc010bfa.2_Frame_Shift_Del_p.D1158fs	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1794						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GCAGGAAAGGATCAGGATGTA	0.408																		25	38	---	---								-	51778370	A	-	51778370	7	5	100	1	0	1	0	1	0	0	0	0	4595	330	12	0	3815	0	DMXL2	15	51778370	Frame_Shift_Del	DEL	A	TCGA-G2-A3VY-01A-11D-A22Z-08	144150	51778370	50753022	603	31197										
LEO1	123169	broad.mit.edu	37	chr15	52242065	52242065	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctgatggactcctcgccttCctcctcctcatcgtatcgat	7	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:52242065C>T	uc002abo.2	-	10	1754	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K	LEO1_uc010bfd.2_Missense_Mutation_p.E520K	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	580					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TCCTCGCCTTCCTCCTCCTCA	0.512													0	0	0	1	0	27	58										T	52242065	C	T	52242065	3	4	100	1	0	0	0	0	1	0	0	0	8726	864	30	1	274	1	LEO1	15	52242065	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	463695	52242065	50289327	604	31198										
ZNF280D	54816	broad.mit.edu	37	chr15	56981644	56981644	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagaagtagaaggacgttttGataaaaatgaactttcactc	8	6	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:56981644G>C	uc002adu.2	-	8	741	c.524C>G	c.(523-525)TCA>TGA	p.S175*	ZNF280D_uc002adv.2_Nonsense_Mutation_p.S162*|ZNF280D_uc010bfq.2_Nonsense_Mutation_p.S175*|ZNF280D_uc002adw.1_Nonsense_Mutation_p.S203*|ZNF280D_uc010bfr.1_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		AGGACGTTTTGATAAAAATGA	0.279													0	0	0	1	0	10	15										C	56981644	G	C	56981644	4	2	100	1	0	0	0	0	0	1	0	0	17814	1294	45	1	2475	1	ZNF280D	15	56981644	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4739579	56981644	45549748	605	31199										
CGNL1	84952	broad.mit.edu	37	chr15	57730472	57730472	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctacattccagcaatggttCtgtgccaaaggagaacagtg	10	9	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:57730472C>G	uc002aeg.2	+	2	351	c.275C>G	c.(274-276)TCT>TGT	p.S92C	CGNL1_uc010bfw.2_Missense_Mutation_p.S92C	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	92	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCAATGGTTCTGTGCCAAAG	0.502													0	0	0	1	0	11	44										G	57730472	C	G	57730472	3	3	100	1	0	0	0	0	1	0	0	0	3304	913	32	1	277	1	CGNL1	15	57730472	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	748828	57730472	44800920	606	31200										
RNF111	54778	broad.mit.edu	37	chr15	59323779	59323779	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atatgccttgctacctagttCtagtagttccagtgagaatg	9	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:59323779C>G	uc002afv.2	+	2	1037	c.758C>G	c.(757-759)TCT>TGT	p.S253C	RNF111_uc002afs.2_Missense_Mutation_p.S253C|RNF111_uc002aft.2_Missense_Mutation_p.S253C|RNF111_uc002afu.2_Missense_Mutation_p.S253C|RNF111_uc002afw.2_Missense_Mutation_p.S253C	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	253	Ser-rich.|Interaction with AXIN1.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		CTACCTAGTTCTAGTAGTTCC	0.408													0	0	0	1	0	6	118										G	59323779	C	G	59323779	3	3	100	1	0	0	0	0	1	0	0	0	13425	913	32	1	760	1	RNF111	15	59323779	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1593307	59323779	43207613	607	31201										
PLEKHO2	80301	broad.mit.edu	37	chr15	65157298	65157298	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtggagacccctgtgggggaGagagccccaacccctgtctc	14	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:65157298G>A	uc002anv.2	+	6	818	c.684G>A	c.(682-684)GAG>GAA	p.E228E	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Silent_p.E178E	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	228	Pro-rich.									ovary(1)|lung(1)	2						CTGTGGGGGAGAGAGCCCCAA	0.637													0	0	0	1	0	8	83										A	65157298	G	A	65157298	2	1	100	1	0	0	0	0	0	0	0	1	12085	933	33	1		1	PLEKHO2	15	65157298	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5833519	65157298	37374094	608	31202										
MTFMT	123263	broad.mit.edu	37	chr15	65295436	65295436	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcatagcaacagtttttttCtgcttcttctttgttggaag	8	7	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:65295436C>G	uc002aof.3	-	9	1160	c.1134G>C	c.(1132-1134)CAG>CAC	p.Q378H		NM_139242	NP_640335	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	378						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			ovary(2)	2					Tetrahydrofolic acid(DB00116)	CAGTTTTTTTCTGCTTCTTCT	0.348													0	0	0	1	0	14	20										G	65295436	C	G	65295436	3	3	100	1	0	0	0	0	1	0	0	0	9924	912	32	1	39	1	MTFMT	15	65295436	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	138138	65295436	37235956	609	31203										
SLC24A1	9187	broad.mit.edu	37	chr15	65917858	65917858	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacgagtacttcgttccagcCctgggtgtcatcacagacaa	10	12	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:65917858C>A	uc010ujf.1	+	2	1727	c.1440C>A	c.(1438-1440)GCC>GCA	p.A480A	SLC24A1_uc010ujd.1_Silent_p.A480A|SLC24A1_uc010uje.1_Silent_p.A480A|SLC24A1_uc010ujg.1_Silent_p.A480A|SLC24A1_uc010ujh.1_Silent_p.A480A	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	480	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TCGTTCCAGCCCTGGGTGTCA	0.582													1	0	1.58986e-06	1	1.65835e-06	10	94										A	65917858	C	A	65917858	2	1	100	1	0	0	0	0	0	0	0	1	14465	610	22	4		4	SLC24A1	15	65917858	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	622422	65917858	36613534	610	31204										
UACA	55075	broad.mit.edu	37	chr15	70960935	70960935	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcccaagttctcctgatttCtgttctaatctgctcttaac	4	12	5	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:70960935C>G	uc002asr.2	-	16	2192	c.2088G>C	c.(2086-2088)CAG>CAC	p.Q696H	UACA_uc010uke.1_Missense_Mutation_p.Q587H|UACA_uc002asq.2_Missense_Mutation_p.Q683H|UACA_uc010bin.1_Missense_Mutation_p.Q671H	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	696	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CTCCTGATTTCTGTTCTAATC	0.363													0	0	0	1	0	27	59										G	70960935	C	G	70960935	3	3	100	1	0	0	0	0	1	0	0	0	16821	912	32	1	2178	1	UACA	15	70960935	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5043077	70960935	31570457	611	31205										
C15orf60	283677	broad.mit.edu	37	chr15	73848666	73848666	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caccagcactcagaacaacaGcaagtgtgtgtaacagcggg	11	11	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:73848666G>C	uc002avq.2	+	5	598	c.570G>C	c.(568-570)CAG>CAC	p.Q190H	C15orf60_uc010bjb.2_Missense_Mutation_p.Q162H	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	190										pancreas(1)	1						CAGAACAACAGCAAGTGTGTG	0.443													0	0	0	1	0	12	34										C	73848666	G	C	73848666	3	2	100	1	0	0	0	0	1	0	0	0	1808	962	34	4	588	4	C15orf60	15	73848666	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2887731	73848666	28682726	612	31206										
CCDC33	80125	broad.mit.edu	37	chr15	74573088	74573088	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagagccgtttgtaccagaaGatgctgacagggaaaggctt	13	7	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:74573088G>C	uc002axo.2	+	9	1363	c.969G>C	c.(967-969)AAG>AAC	p.K323N	CCDC33_uc002axp.2_Missense_Mutation_p.K145N	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	526							protein binding			ovary(3)|skin(2)	5						TGTACCAGAAGATGCTGACAG	0.577													0	0	0	1	0	17	55										C	74573088	G	C	74573088	3	2	100	1	0	0	0	0	1	0	0	0	2806	933	33	1	1003	1	CCDC33	15	74573088	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	724422	74573088	27958304	613	31207										
LMAN1L	79748	broad.mit.edu	37	chr15	75108987	75108987	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgcaggacagtcctgccatCcgtgtgctggccagcgacgg	14	14	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:75108987C>T	uc002ayt.1	+	4	455	c.453C>T	c.(451-453)ATC>ATT	p.I151I	LMAN1L_uc010bkd.2_Silent_p.I79I|LMAN1L_uc010ulo.1_Silent_p.I43I|LMAN1L_uc010bke.1_Silent_p.I151I	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	151	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GTCCTGCCATCCGTGTGCTGG	0.488													0	0	0	1	0	5	47										T	75108987	C	T	75108987	2	4	100	1	0	0	0	0	0	0	0	1	8837	845	30	1		1	LMAN1L	15	75108987	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	535899	75108987	27422405	614	31208										
PTPN9	5780	broad.mit.edu	37	chr15	75798197	75798197	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagggagaacaggatgatctCatcgaagggatctgggtggc	17	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:75798197C>T	uc002bal.2	-	7	1295	c.787G>A	c.(787-789)GAG>AAG	p.E263K		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	263						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						AGGATGATCTCATCGAAGGGA	0.512													0	0	0	1	0	29	15										T	75798197	C	T	75798197	3	4	100	1	0	0	0	0	1	0	0	0	12794	835	29	1	1022	1	PTPN9	15	75798197	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	689210	75798197	26733195	615	31209										
SGK269	79834	broad.mit.edu	37	chr15	77407505	77407505	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catgtcatcctcatccttttCagggtcatctggatcctccc	6	15	5	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:77407505C>G	uc002bcm.2	-	6	4542	c.4234G>C	c.(4234-4236)GAA>CAA	p.E1412Q		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1412	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCATCCTTTTCAGGGTCATCT	0.498													0	0	0	1	0	17	58										G	77407505	C	G	77407505	3	3	100	1	0	0	0	0	1	0	0	0	14211	835	29	1	1010	1	SGK269	15	77407505	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1609308	77407505	25123887	616	31210										
ACAN	176	broad.mit.edu	37	chr15	89398590	89398590	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accctcaggggatgaagagaGaattgagtggcccagcactc	13	10	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:89398590G>A	uc010upo.1	+	12	3148	c.2774G>A	c.(2773-2775)AGA>AAA	p.R925K	ACAN_uc010upp.1_Missense_Mutation_p.R925K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	925					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATGAAGAGAGAATTGAGTGG	0.577													0	0	0	1	0	15	32										A	89398590	G	A	89398590	3	1	100	1	0	0	0	0	1	0	0	0	117	942	33	1	2816	1	ACAN	15	89398590	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	11991085	89398590	13132802	617	31211										
C15orf58	390637	broad.mit.edu	37	chr15	90784743	90784743	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgagcttacacccgggcttCcgtgtcggcttcaacagcct	10	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:90784743C>T	uc002bpc.2	+	4	782	c.603C>T	c.(601-603)TTC>TTT	p.F201F		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	201					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						ACCCGGGCTTCCGTGTCGGCT	0.667													0	0	0	1	0	12	25										T	90784743	C	T	90784743	2	4	100	1	0	0	0	0	0	0	0	1	1806	854	30	1		1	C15orf58	15	90784743	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1386153	90784743	11746649	618	31212										
PCSK6	5046	broad.mit.edu	37	chr15	101872078	101872078	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtgtaatcttcctcatcttCaggaacttccacctgggagg	9	11	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:101872078C>A	uc002bwy.2	-	15	2331	c.2017G>T	c.(2017-2019)GAA>TAA	p.E673*	PCSK6_uc010bpd.2_Nonsense_Mutation_p.E469*|PCSK6_uc010bpe.2_Nonsense_Mutation_p.E673*|PCSK6_uc002bxa.2_Nonsense_Mutation_p.E673*|PCSK6_uc002bxb.2_Nonsense_Mutation_p.E673*	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	673					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCCTCATCTTCAGGAACTTCC	0.557													1	0	0.014758	1	0.0148163	4	46										A	101872078	C	A	101872078	4	1	100	1	0	0	0	0	0	1	0	0	11604	835	29	3	1157	3	PCSK6	15	101872078	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11087335	101872078	659314	619	31213										
RHBDF1	64285	broad.mit.edu	37	chr16	111597	111597	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctcaccgagtccaccgtctCatgctgcgagaagcccacgg	11	16	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:111597C>T	uc002cfl.3	-	12	1454	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	RHBDF1_uc010uty.1_Missense_Mutation_p.E459K|RHBDF1_uc010utz.1_Missense_Mutation_p.E436K|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	436	Lumenal (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				TCCACCGTCTCATGCTGCGAG	0.657													0	0	0	1	0	28	49										T	111597	C	T	111597	3	4	100	1	0	0	0	0	1	0	0	0	13319	835	29	1	1301	1	RHBDF1	16	111597	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		111597	90243156	620	31214										
HBQ1	3049	broad.mit.edu	37	chr16	230775	230776	+	Missense_Mutation	DNP	TC	TC	AA													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtggcggacgcgctgagccTcgccgtggagcgcctggacg							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:230775_230776TC>AA	uc002cfz.2	+	2	357_358	c.206_207TC>AA	c.(205-207)CTC>CAA	p.L69Q		NM_005331	NP_005322	P09105	HBAT_HUMAN	theta 1 globin	69						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				GCGCTGAGCCTCGCCGTGGAGC	0.698													0	0	0	1	0	3	12										AA	230776	TC	AA	230775	3	1	100	1	0	0	0	0	1	0	0	0	6986	1551	54	5	212	5	HBQ1	16	230775	Missense_Mutation	DNP	TC	TCGA-G2-A3VY-01A-11D-A22Z-08	119178	230775	90123978	621	31215										
PIGQ	9091	broad.mit.edu	37	chr16	632999	632999	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgttccttggggagctcatCtacccctggaggcagagagg	14	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:632999C>T	uc002cho.2	+	10	1750	c.1648C>T	c.(1648-1650)CTA>TTA	p.L550L	PIGQ_uc010bqw.2_Silent_p.I570I|PIGQ_uc002chn.2_Silent_p.I570I|PIGQ_uc010uui.1_3'UTR|PIGQ_uc002chp.2_Silent_p.L120L|uc010uuj.1_3'UTR	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	550					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				GGGAGCTCATCTACCCCTGGA	0.672													0	0	0	1	0	57	72										T	632999	C	T	632999	2	4	100	1	0	0	0	0	0	0	0	1	11896	912	32	1		1	PIGQ	16	632999	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	402224	632999	89721754	622	31216										
FAM195A	84331	broad.mit.edu	37	chr16	697470	697470	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggccggcgggccccctccaCgtccccatccttcgagggga	13	18	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:697470C>T	uc002cic.1	+	3	379	c.236C>T	c.(235-237)ACG>ATG	p.T79M	FAM195A_uc002cid.1_Intron|FAM195A_uc002cie.2_Missense_Mutation_p.R8C|FAM195A_uc002cif.1_RNA|WDR90_uc002cig.1_5'Flank|WDR90_uc002cih.1_5'Flank|WDR90_uc002cii.1_5'Flank|WDR90_uc002cij.1_5'Flank	NM_138418	NP_612427	Q9BUT9	F195A_HUMAN	hypothetical protein LOC84331	79											0						GCCCCCTCCACGTCCCCATCC	0.647													0	0	0	1	0	20	14										T	697470	C	T	697470	3	4	100	1	0	0	0	0	1	0	0	0	5527	536	19	2	246	2	FAM195A	16	697470	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	64471	697470	89657283	623	31217										
PKD1	5310	broad.mit.edu	37	chr16	2153270	2153270	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccacccgctgcacgcaccgtCcagcagcgtatagttgagct	10	16	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:2153270C>A	uc002cos.1	-	23	8997	c.8788G>T	c.(8788-8790)GAC>TAC	p.D2930Y	PKD1_uc002cot.1_Missense_Mutation_p.D2930Y|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2930	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CACGCACCGTCCAGCAGCGTA	0.647													1	0	1.85244e-09	1	1.9727e-09	25	12										A	2153270	C	A	2153270	3	1	100	1	0	0	0	0	1	0	0	0	11963	855	30	3	4219	3	PKD1	16	2153270	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1455800	2153270	88201483	624	31218										
PKD1	5310	broad.mit.edu	37	chr16	2153839	2153839	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccgagatggtgactcggctCccagctctgagggctgtggt	15	11	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:2153839C>T	uc002cos.1	-	23	8428	c.8219G>A	c.(8218-8220)GGA>GAA	p.G2740E	PKD1_uc002cot.1_Missense_Mutation_p.G2740E|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2740	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TGACTCGGCTCCCAGCTCTGA	0.597													0	0	0	1	0	13	4										T	2153839	C	T	2153839	3	4	100	1	0	0	0	0	1	0	0	0	11963	855	30	1	4788	1	PKD1	16	2153839	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	569	2153839	88200914	625	31219										
MMP25	64386	broad.mit.edu	37	chr16	3100351	3100351	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggggcatggagtcaggcctCacatttcatgaggtggattc	14	8	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:3100351C>G	uc002cth.2	+	4	702	c.465C>G	c.(463-465)CTC>CTG	p.L155L	MMP25_uc002cti.1_Silent_p.L91L	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	155					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						AGTCAGGCCTCACATTTCATG	0.637													0	0	0	1	0	15	35										G	3100351	C	G	3100351	2	3	100	1	0	0	0	0	0	0	0	1	9662	813	29	1		1	MMP25	16	3100351	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	946512	3100351	87254402	626	31220										
TXNDC11	51061	broad.mit.edu	37	chr16	11773080	11773080	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctgttctccttattcctttCagacaccagtgtggcgctga	8	13	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:11773080C>G	uc010buu.1	-	13	2991	c.2929G>C	c.(2929-2931)GAA>CAA	p.E977Q	TXNDC11_uc002dbg.1_Missense_Mutation_p.E950Q	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	977					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						TTATTCCTTTCAGACACCAGT	0.478													0	0	0	1	0	14	44										G	11773080	C	G	11773080	3	3	100	1	0	0	0	0	1	0	0	0	16789	835	29	1	32	1	TXNDC11	16	11773080	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	8672729	11773080	78581673	627	31221										
NOMO3	408050	broad.mit.edu	37	chr16	16349968	16349968	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tactttgaaacggtcaccatCaaaattgcaccaaacacacc	4	13	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:16349968C>T	uc002deq.2	+	11	1308	c.1173C>T	c.(1171-1173)ATC>ATT	p.I391I	NOMO3_uc002dep.2_Silent_p.I391I|NOMO3_uc010bvp.1_Silent_p.I224I	NM_001004067	NP_001004067	P69849	NOMO3_HUMAN	nodal modulator 3 precursor	391	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CGGTCACCATCAAAATTGCAC	0.468													0	0	0	1	0	40	119										T	16349968	C	T	16349968	2	4	100	1	0	0	0	0	0	0	0	1	10533	816	29	1		1	NOMO3	16	16349968	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4576888	16349968	74004785	628	31222										
DNAH3	55567	broad.mit.edu	37	chr16	20998710	20998710	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgtcctccttgtcaatcaGacgatcatagaagacccgat	7	12	4	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:20998710G>C	uc010vbe.1	-	47	6943	c.6943C>G	c.(6943-6945)CTG>GTG	p.L2315V	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2315					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGTCAATCAGACGATCATAG	0.413													0	0	0	1	0	42	75										C	20998710	G	C	20998710	3	2	100	1	0	0	0	0	1	0	0	0	4603	933	33	1	5470	1	DNAH3	16	20998710	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4648742	20998710	69356043	629	31223										
DNAH3	55567	broad.mit.edu	37	chr16	21065842	21065842	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcgcaatctgatcattgctcTttttcagaaaatcctggaag	8	9	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:21065842T>A	uc010vbe.1	-	28	3938	c.3938A>T	c.(3937-3939)AAG>ATG	p.K1313M		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1313	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATCATTGCTCTTTTTCAGAAA	0.537													0	0	0	1	0	9	30										A	21065842	T	A	21065842	3	1	100	1	0	0	0	0	1	0	0	0	4603	1609	56	5	8551	5	DNAH3	16	21065842	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	67132	21065842	69288911	630	31224										
IL21R	50615	broad.mit.edu	37	chr16	27456025	27456025	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggagtgacccggtcatctttCagacccagtcagagggtagg	14	10	4	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:27456025C>A	uc002doq.1	+	6	903	c.670C>A	c.(670-672)CAG>AAG	p.Q224K	IL21R_uc002dor.1_Missense_Mutation_p.Q224K|IL21R_uc002dos.1_Missense_Mutation_p.Q224K	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	224	Extracellular (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GGTCATCTTTCAGACCCAGTC	0.582			T	BCL6	NHL								1	0	0.000673444	1	0.000684208	11	40										A	27456025	C	A	27456025	3	1	100	1	0	0	0	0	1	0	0	0	7671	827	29	3	688	3	IL21R	16	27456025	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6390183	27456025	62898728	631	31225										
PRRT2	112476	broad.mit.edu	37	chr16	29824976	29824976	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agggcccagcccctgagcctCactcaccaccctcaaaaaaa	6	18	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:29824976C>T	uc002due.3	+	2	902	c.601C>T	c.(601-603)CAC>TAC	p.H201Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.H201Y|PRRT2_uc002duf.1_Missense_Mutation_p.H201Y|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	201	Extracellular (Potential).|Pro-rich.				response to biotic stimulus	integral to membrane					0						CCCTGAGCCTCACTCACCACC	0.612													0	0	0	1	0	7	11										T	29824976	C	T	29824976	3	4	100	1	0	0	0	0	1	0	0	0	12610	826	29	1	603	1	PRRT2	16	29824976	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2368951	29824976	60529777	632	31226										
PPP4C	5531	broad.mit.edu	37	chr16	30096314	30096314	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctccagaaagatttcatcatCtttgaggctgctccccaaga	7	12	3	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:30096314C>G	uc002dwe.2	+	9	999	c.855C>G	c.(853-855)ATC>ATG	p.I285M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.I285M|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_Missense_Mutation_p.I206M	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	285					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						ATTTCATCATCTTTGAGGCTG	0.627													0	0	0	1	0	33	59										G	30096314	C	G	30096314	3	3	100	1	0	0	0	0	1	0	0	0	12402	903	32	1	885	1	PPP4C	16	30096314	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	271338	30096314	60258439	633	31227										
ARMC5	79798	broad.mit.edu	37	chr16	31470893	31470893	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gactcgctctcgttctgcctCgcgcagctcgcggcggcggc	14	17	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:31470893C>T	uc002ecc.2	+	1	577	c.48C>T	c.(46-48)CTC>CTT	p.L16L	ARMC5_uc010vfn.1_Silent_p.L111L|ARMC5_uc010vfo.1_Silent_p.L48L|ARMC5_uc002eca.3_Silent_p.L16L|ARMC5_uc010vfp.1_Silent_p.L16L|ARMC5_uc002ecb.2_Silent_p.L16L	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	16							binding			pancreas(1)	1						CGTTCTGCCTCGCGCAGCTCG	0.716													0	0	0	1	0	5	8										T	31470893	C	T	31470893	2	4	100	1	0	0	0	0	0	0	0	1	954	871	31	1		1	ARMC5	16	31470893	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1374579	31470893	58883860	634	31228										
PHKB	5257	broad.mit.edu	37	chr16	47733202	47733202	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agaggaacatgcagctatttGacaaaggcggtgatgaatct	12	6	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:47733202G>C	uc002eev.3	+	31	3259	c.3207G>C	c.(3205-3207)TTG>TTC	p.L1069F	PHKB_uc002eeu.3_Missense_Mutation_p.L1062F|PHKB_uc002eew.3_Missense_Mutation_p.L310F	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	1069					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GCAGCTATTTGACAAAGGCGG	0.463													0	0	0	1	0	26	90										C	47733202	G	C	47733202	3	2	100	1	0	0	0	0	1	0	0	0	11845	1281	45	1	3483	1	PHKB	16	47733202	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	16262309	47733202	42621551	635	31229										
LONP2	83752	broad.mit.edu	37	chr16	48368170	48368170	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gatgaaaaacctgaatctatCagtgacactactgacttggc	8	9	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:48368170C>T	uc002efi.1	+	12	1928	c.1839C>T	c.(1837-1839)ATC>ATT	p.I613I	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Silent_p.I569I	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	613					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						CTGAATCTATCAGTGACACTA	0.393													0	0	0	1	0	24	77										T	48368170	C	T	48368170	2	4	100	1	0	0	0	0	0	0	0	1	8893	816	29	1		1	LONP2	16	48368170	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	634968	48368170	41986583	636	31230										
SALL1	6299	broad.mit.edu	37	chr16	51175982	51175982	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atctgataattcaaagaactCggcacagcaccggccacaga	8	12	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:51175982C>G	uc010vgs.1	-	2	182	c.151G>C	c.(151-153)GAG>CAG	p.E51Q	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	51					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCAAAGAACTCGGCACAGCAC	0.453													0	0	0	1	0	107	55										G	51175982	C	G	51175982	3	3	100	1	0	0	0	0	1	0	0	0	13810	893	31	1	3831	1	SALL1	16	51175982	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2807812	51175982	39178771	637	31231										
OGFOD1	55239	broad.mit.edu	37	chr16	56504661	56504661	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acaacagccaacagagcaatGagcagacagacccagagcca	9	13	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:56504661G>A	uc002ejb.2	+	10	1344	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	OGFOD1_uc002ejc.2_Missense_Mutation_p.E275K	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	415							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	ACAGAGCAATGAGCAGACAGA	0.438													0	0	0	1	0	3	14										A	56504661	G	A	56504661	3	1	100	1	0	0	0	0	1	0	0	0	10841	1291	45	1	1281	1	OGFOD1	16	56504661	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5328679	56504661	33850092	638	31232										
CNOT1	23019	broad.mit.edu	37	chr16	58565903	58565903	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagcattcttgcaataaataTccgatgggaaatcagttcaa	7	8	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:58565903T>C	uc002env.2	-	42	6429	c.6136A>G	c.(6136-6138)ATA>GTA	p.I2046V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.I2041V|CNOT1_uc002ent.2_5'UTR|CNOT1_uc010vik.1_Missense_Mutation_p.I1003V	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2046					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCAATAAATATCCGATGGGAA	0.423													0	0	0	1	0	99	33										C	58565903	T	C	58565903	3	2	100	1	0	0	0	0	1	0	0	0	3617	1435	50	5	1026	5	CNOT1	16	58565903	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	2061242	58565903	31788850	639	31233										
CMTM4	146223	broad.mit.edu	37	chr16	66651180	66651180	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacccatcatctgaacttttCtaggcaagttgccagtgatt	8	10	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:66651180C>G	uc002epz.2	-	5	887	c.705G>C	c.(703-705)TAG>TAC	p.*235Y	CMTM4_uc002eqa.2_3'UTR	NM_178818	NP_848933	Q8IZR5	CKLF4_HUMAN	chemokine-like factor superfamily 4 isoform 1	235					chemotaxis	extracellular space|integral to membrane	cytokine activity			pancreas(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		CTGAACTTTTCTAGGCAAGTT	0.363													0	0	0	1	0	10	40										G	66651180	C	G	66651180	4	3	100	1	0	0	0	0	0	0	0	0	3585	924	32	1	3	1	CMTM4	16	66651180	Nonstop_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	8085277	66651180	23703573	640	31234										
DYNC1LI2	1783	broad.mit.edu	37	chr16	66783140	66783140	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acactgaggtagagatattcTaggcctcttccttttttgcc	8	10	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:66783140T>A	uc002eqb.1	-	3	289	c.258A>T	c.(256-258)CTA>CTT	p.L86L	DYNC1LI2_uc010vis.1_Silent_p.L86L|DYNC1LI2_uc010vit.1_Silent_p.L86L|DYNC1LI2_uc010viu.1_Intron	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	86					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		AGAGATATTCTAGGCCTCTTC	0.468													0	0	0	1	0	35	62										A	66783140	T	A	66783140	2	1	100	1	0	0	0	0	0	0	0	1	4845	1509	53	5		5	DYNC1LI2	16	66783140	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	131960	66783140	23571613	641	31235										
ELMO3	79767	broad.mit.edu	37	chr16	67236431	67236431	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggctacacaggaggacttcGacaaggtgggtggggtggga	20	6	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:67236431G>A	uc002esa.2	+	14	1595	c.1552G>A	c.(1552-1554)GAC>AAC	p.D518N	ELMO3_uc002esb.2_Missense_Mutation_p.D501N|ELMO3_uc002esc.2_Missense_Mutation_p.D352N|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	465	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GGAGGACTTCGACAAGGTGGG	0.622													0	0	0	1	0	35	86										A	67236431	G	A	67236431	3	1	100	1	0	0	0	0	1	0	0	0	5067	1058	37	1	1606	1	ELMO3	16	67236431	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	453291	67236431	23118322	642	31236										
FHOD1	29109	broad.mit.edu	37	chr16	67263797	67263797	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaaggtccatgatctcatctGatgtatcactgggtaaactg	10	8	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:67263797G>A	uc002esl.2	-	21	3423	c.3311C>T	c.(3310-3312)TCA>TTA	p.S1104L	LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|FHOD1_uc002esk.2_Missense_Mutation_p.S163L|FHOD1_uc010ced.2_Missense_Mutation_p.S911L	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1104					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GATCTCATCTGATGTATCACT	0.582													0	0	0	1	0	7	118										A	67263797	G	A	67263797	3	1	100	1	0	0	0	0	1	0	0	0	5882	1294	45	1	191	1	FHOD1	16	67263797	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	27366	67263797	23090956	643	31237										
FHOD1	29109	broad.mit.edu	37	chr16	67273347	67273347	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agggagacacttgcagagcaCaatcctccaactgggggcaa	12	11	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:67273347C>G	uc002esl.2	-	2	324	c.212G>C	c.(211-213)TGT>TCT	p.C71S	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	71	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TTGCAGAGCACAATCCTCCAA	0.557													0	0	0	1	0	11	68										G	67273347	C	G	67273347	3	3	100	1	0	0	0	0	1	0	0	0	5882	478	17	4	3366	4	FHOD1	16	67273347	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9550	67273347	23081406	644	31238										
COG8	84342	broad.mit.edu	37	chr16	69369059	69369059	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atcatcattaggaatggcagTcaggatggaccggagccaag	13	8	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:69369059T>C	uc002ewy.2	-	3	849	c.778A>G	c.(778-780)ACT>GCT	p.T260A	COG8_uc002ewz.3_Missense_Mutation_p.T260A	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	260					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						GGAATGGCAGTCAGGATGGAC	0.517													0	0	0	1	0	8	45										C	69369059	T	C	69369059	3	2	100	1	0	0	0	0	1	0	0	0	3664	1667	58	5	1072	5	COG8	16	69369059	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	2095712	69369059	20985694	645	31239										
SF3B3	23450	broad.mit.edu	37	chr16	70603923	70603923	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcacaggcagaggtgatcatGaactaccatgtcggggagac	13	9	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:70603923G>T	uc002ezf.2	+	24	3490	c.3279G>T	c.(3277-3279)ATG>ATT	p.M1093I		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1093					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				AGGTGATCATGAACTACCATG	0.552													1	0	1.02788e-11	1	1.1109e-11	17	55										T	70603923	G	T	70603923	3	4	100	1	0	0	0	0	1	0	0	0	14152	1290	45	3	3369	3	SF3B3	16	70603923	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1234864	70603923	19750830	646	31240										
ADAT1	23536	broad.mit.edu	37	chr16	75646313	75646313	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catggagcgtgttctgtctcCacggcctggcttcactcgga	12	13	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:75646313C>T	uc002feo.1	-	7	973	c.871G>A	c.(871-873)GGA>AGA	p.G291R	ADAT1_uc002fep.1_Missense_Mutation_p.G142R	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	291	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						GTTCTGTCTCCACGGCCTGGC	0.587													0	0	0	1	0	17	77										T	75646313	C	T	75646313	3	4	100	1	0	0	0	0	1	0	0	0	284	603	21	2	657	2	ADAT1	16	75646313	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	5042390	75646313	14708440	647	31241										
CNTNAP4	85445	broad.mit.edu	37	chr16	76556045	76556045	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggcaccatgtgagggttgaAaggaacatgaaggaggcctc	15	7	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:76556045A>G	uc002feu.1	+	19	3031	c.2646A>G	c.(2644-2646)GAA>GAG	p.E882E	CNTNAP4_uc002fev.1_Silent_p.E746E|CNTNAP4_uc010chb.1_Silent_p.E809E|CNTNAP4_uc002fex.1_Silent_p.E885E	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	882	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGAGGGTTGAAAGGAACATGA	0.522													0	0	0	1	0	48	139										G	76556045	A	G	76556045	2	3	100	1	0	0	0	0	0	0	0	1	3649	11	1	5		5	CNTNAP4	16	76556045	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	909732	76556045	13798708	648	31242										
ATMIN	23300	broad.mit.edu	37	chr16	81077671	81077671	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catttttgagagtgttcattCatcatataatgttgctacag	7	6	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81077671C>G	uc002ffz.1	+	4	1586	c.1568C>G	c.(1567-1569)TCA>TGA	p.S523*	ATMIN_uc002fga.2_Nonsense_Mutation_p.S365*|ATMIN_uc010vnn.1_Nonsense_Mutation_p.S294*|ATMIN_uc002fgb.1_Nonsense_Mutation_p.S365*	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	523					response to DNA damage stimulus	nucleus	zinc ion binding				0						AGTGTTCATTCATCATATAAT	0.393													0	0	0	1	0	26	66										G	81077671	C	G	81077671	4	3	100	1	0	0	0	0	0	1	0	0	1110	838	29	1	1582	1	ATMIN	16	81077671	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4521626	81077671	9277082	649	31243			3	137		4	4	713	N	G_C	1.200768e-06
ATMIN	23300	broad.mit.edu	37	chr16	81078172	81078172	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcagtcctatgggtgtagggGaaattctaacttcttaggcc	11	8	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81078172G>A	uc002ffz.1	+	4	2087	c.2069G>A	c.(2068-2070)GGA>GAA	p.G690E	ATMIN_uc002fga.2_Missense_Mutation_p.G532E|ATMIN_uc010vnn.1_Missense_Mutation_p.G461E|ATMIN_uc002fgb.1_Missense_Mutation_p.G532E	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	690					response to DNA damage stimulus	nucleus	zinc ion binding				0						GGGTGTAGGGGAAATTCTAAC	0.468													0	0	0	1	0	93	217										A	81078172	G	A	81078172	3	1	100	1	0	0	0	0	1	0	0	0	1110	1174	41	1	2083	1	ATMIN	16	81078172	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	501	81078172	9276581	650	31244			3	137		4	4	713	N	G_C	1.200768e-06
ATMIN	23300	broad.mit.edu	37	chr16	81078303	81078303	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccagcttttccgtgagtactGattcatctgacacagagacc	8	12	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81078303G>T	uc002ffz.1	+	4	2218	c.2200G>T	c.(2200-2202)GAT>TAT	p.D734Y	ATMIN_uc002fga.2_Missense_Mutation_p.D576Y|ATMIN_uc010vnn.1_Missense_Mutation_p.D505Y|ATMIN_uc002fgb.1_Missense_Mutation_p.D576Y	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	734					response to DNA damage stimulus	nucleus	zinc ion binding				0						CGTGAGTACTGATTCATCTGA	0.428													1	0	3.76114e-14	1	4.10857e-14	37	221										T	81078303	G	T	81078303	3	4	100	1	0	0	0	0	1	0	0	0	1110	1290	45	3	2214	3	ATMIN	16	81078303	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	131	81078303	9276450	651	31245			3	137		4	4	713	N	G_C	1.200768e-06
ATMIN	23300	broad.mit.edu	37	chr16	81078383	81078383	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctagaaagcaaagttcagttGaacagtacagaaacacagac	8	8	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81078383G>A	uc002ffz.1	+	4	2298	c.2280G>A	c.(2278-2280)TTG>TTA	p.L760L	ATMIN_uc002fga.2_Silent_p.L602L|ATMIN_uc010vnn.1_Silent_p.L531L|ATMIN_uc002fgb.1_Silent_p.L602L	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	760					response to DNA damage stimulus	nucleus	zinc ion binding				0						AAGTTCAGTTGAACAGTACAG	0.448													0	0	0	1	0	46	141										A	81078383	G	A	81078383	2	1	100	1	0	0	0	0	0	0	0	1	1110	1281	45	1		1	ATMIN	16	81078383	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	80	81078383	9276370	652	31246			3	137		4	4	713	N	G_C	1.200768e-06
KIAA0513	9764	broad.mit.edu	37	chr16	85100813	85100813	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggacggtgcatcagagagtGagaccactgagtctgcggac	16	9	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:85100813G>C	uc002fiu.2	+	2	356	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	KIAA0513_uc002fis.3_Missense_Mutation_p.E46Q|KIAA0513_uc010voj.1_Missense_Mutation_p.E46Q|KIAA0513_uc002fit.2_Missense_Mutation_p.E46Q	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	46						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		ATCAGAGAGTGAGACCACTGA	0.647													0	0	0	1	0	15	46										C	85100813	G	C	85100813	3	2	100	1	0	0	0	0	1	0	0	0	8181	1291	45	1	138	1	KIAA0513	16	85100813	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4022430	85100813	5253940	653	31247										
FBXO31	79791	broad.mit.edu	37	chr16	87365010	87365010	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggctgaaggatttcagctCcagccagacgaacccgaagc	11	13	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:87365010C>G	uc002fjw.2	-	9	1548	c.1504G>C	c.(1504-1506)GAG>CAG	p.E502Q	FBXO31_uc010vot.1_Missense_Mutation_p.E330Q|FBXO31_uc002fjv.2_Missense_Mutation_p.E394Q	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	502					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GATTTCAGCTCCAGCCAGACG	0.622													0	0	0	1	0	14	24										G	87365010	C	G	87365010	3	3	100	1	0	0	0	0	1	0	0	0	5741	864	30	1	119	1	FBXO31	16	87365010	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2264197	87365010	2989743	654	31248										
ZFPM1	161882	broad.mit.edu	37	chr16	88594547	88594547	+	Nonsense_Mutation	SNP	G	G	T													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccggccaccctgtgaagaagGagccagcagagcccacgtgc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:88594547G>T	uc002fkv.2	+	6	646	c.613G>T	c.(613-615)GAG>TAG	p.E205*		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	205					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TGTGAAGAAGGAGCCAGCAGA	0.697													1	0	0.014758	1	0.0148163	4	11										T	88594547	G	T	88594547	4	4	100	1	0	0	0	0	0	1	0	0	17654	1175	41	3	635	3	ZFPM1	16	88594547	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1229537	88594547	1760206	655	31249	156	2								
ZFPM1	161882	broad.mit.edu	37	chr16	88594556	88594556	+	Missense_Mutation	SNP	G	G	C													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgtgaagaaggagccagcaGagcccacgtgcccggcccct							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:88594556G>C	uc002fkv.2	+	6	655	c.622G>C	c.(622-624)GAG>CAG	p.E208Q		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	208					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GGAGCCAGCAGAGCCCACGTG	0.692													0	0	0	1	0	3	14										C	88594556	G	C	88594556	3	2	100	1	0	0	0	0	1	0	0	0	17654	943	33	1	644	1	ZFPM1	16	88594556	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	9	88594556	1760197	656	31250	156	2								
CDT1	81620	broad.mit.edu	37	chr16	88871024	88871024	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccgggccagaagataaagaaAtccaccccggcagcaggtca	11	13	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:88871024A>C	uc002flu.2	+	2	354	c.300A>C	c.(298-300)AAA>AAC	p.K100N		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	100					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		AGATAAAGAAATCCACCCCGG	0.687													0	0	0	1	0	20	28										C	88871024	A	C	88871024	3	2	100	1	0	0	0	0	1	0	0	0	3180	98	4	5	306	5	CDT1	16	88871024	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	276468	88871024	1483729	657	31251										
ANKRD11	29123	broad.mit.edu	37	chr16	89348054	89348054	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcaggaatgtccagacccttCttccgcccgtcgtctgccgg	11	16	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:89348054C>G	uc002fmx.1	-	9	5357	c.4896G>C	c.(4894-4896)AAG>AAC	p.K1632N	ANKRD11_uc002fmy.1_Missense_Mutation_p.K1632N|ANKRD11_uc002fnc.1_Missense_Mutation_p.K1632N|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.K1589N	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1632	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCAGACCCTTCTTCCGCCCGT	0.572													0	0	0	1	0	10	126										G	89348054	C	G	89348054	3	3	100	1	0	0	0	0	1	0	0	0	639	912	32	1	3115	1	ANKRD11	16	89348054	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	477030	89348054	1006699	658	31252										
ZNF276	92822	broad.mit.edu	37	chr16	89799709	89799709	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgggaacctctttttttcaGagtctctggtaagaagagtg	11	6	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:89799709G>C	uc002fos.3	+	7	1267	c.1170_splice	c.e7-1	p.K390_splice	ZNF276_uc010ciq.2_Splice_Site_p.K176_splice|ZNF276_uc002fop.2_Splice_Site_p.K298_splice|ZNF276_uc002foq.3_Splice_Site_p.K315_splice|ZNF276_uc010cir.2_Splice_Site|ZNF276_uc002for.3_Splice_Site_p.K176_splice|ZNF276_uc010cis.2_Splice_Site_p.K149_splice|ZNF276_uc002fot.3_Splice_Site|ZNF276_uc010vpm.1_Splice_Site_p.K228_splice|ZNF276_uc010cit.1_Splice_Site_p.K149_splice	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTTTTTTTCAGAGTCTCTGGT	0.428													0	0	0	1	0	31	111										C	89799709	G	C	89799709	5	2	100	1	0	0	0	0	0	0	1	0	17808	956	33	1	1195	1	ZNF276	16	89799709	Splice_Site	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	451655	89799709	555044	659	31253										
FANCA	2175	broad.mit.edu	37	chr16	89838145	89838145	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagctgaatctttgatatctCaacgctgctgtcatcctcat	7	11	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:89838145C>T	uc002fou.1	-	23	2134	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	FANCA_uc010vpn.1_Missense_Mutation_p.E698K	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	698					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TTTGATATCTCAACGCTGCTG	0.517			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	1	0	29	64										T	89838145	C	T	89838145	3	4	100	1	0	0	0	0	1	0	0	0	5662	835	29	1	2359	1	FANCA	16	89838145	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	38436	89838145	516608	660	31254										
PRPF8	10594	broad.mit.edu	37	chr17	1564436	1564436	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgccgctggtgtgtccaccaGaacggattctgcttcaaaac	10	12	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564436G>A	uc002fte.2	-	28	4473	c.4359C>T	c.(4357-4359)TTC>TTT	p.F1453F		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1453						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GTGTCCACCAGAACGGATTCT	0.547													0	0	0	1	0	44	4										A	1564436	G	A	1564436	2	1	100	1	0	0	0	0	0	0	0	1	12575	933	33	1		1	PRPF8	17	1564436	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		1564436	79630774	661	31255			4	138		4	4	527	G		4.852659e-07
PRPF8	10594	broad.mit.edu	37	chr17	1564447	1564447	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtccaccagaacggattctGcttcaaaacctagatggcaa	8	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564447G>C	uc002fte.2	-	28	4462	c.4348C>G	c.(4348-4350)CAG>GAG	p.Q1450E		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1450						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AACGGATTCTGCTTCAAAACC	0.542													0	0	0	1	0	45	5										C	1564447	G	C	1564447	3	2	100	1	0	0	0	0	1	0	0	0	12575	1328	46	4	2723	4	PRPF8	17	1564447	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	11	1564447	79630763	662	31256			4	138		4	4	527	G		4.852659e-07
PRPF8	10594	broad.mit.edu	37	chr17	1564634	1564634	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtgtgtgccggtccttctgGaagagggtattgattcgagg	16	6	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564634G>A	uc002fte.2	-	27	4383	c.4269C>T	c.(4267-4269)TTC>TTT	p.F1423F		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1423						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGTCCTTCTGGAAGAGGGTAT	0.458													0	0	0	1	0	101	11										A	1564634	G	A	1564634	2	1	100	1	0	0	0	0	0	0	0	1	12575	1165	41	1		1	PRPF8	17	1564634	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	187	1564634	79630576	663	31257			4	138		4	4	527	G		4.852659e-07
PRPF8	10594	broad.mit.edu	37	chr17	1564962	1564962	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actcagcccagacccgctgaGaatcaatgaactcgctctcc	7	16	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564962G>C	uc002fte.2	-	26	4259	c.4145C>G	c.(4144-4146)TCT>TGT	p.S1382C		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1382						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GACCCGCTGAGAATCAATGAA	0.552													0	0	0	1	0	47	6										C	1564962	G	C	1564962	3	2	100	1	0	0	0	0	1	0	0	0	12575	942	33	1	2934	1	PRPF8	17	1564962	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	328	1564962	79630248	664	31258			4	138		4	4	527	G		4.852659e-07
OR1E2	8388	broad.mit.edu	37	chr17	3336869	3336869	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgcataggggatggatggGtcttggttctgcatgttctg	15	6	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:3336869G>C	uc010vre.1	-	1	267	c.267C>G	c.(265-267)GAC>GAG	p.D89E		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	89	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGATGGATGGGTCTTGGTTCT	0.483													0	0	0	1	0	19	26										C	3336869	G	C	3336869	3	2	100	1	0	0	0	0	1	0	0	0	10955	1252	44	4	707	4	OR1E2	17	3336869	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1771907	3336869	77858341	665	31259										
ZZEF1	23140	broad.mit.edu	37	chr17	3992006	3992006	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctgctggataaactgaaggGtcctgaggagcaacgtggcc	15	9	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:3992006G>A	uc002fxe.2	-	13	2271	c.2207C>T	c.(2206-2208)ACC>ATC	p.T736I	ZZEF1_uc002fxk.1_Missense_Mutation_p.T736I	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	736							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAACTGAAGGGTCCTGAGGAG	0.527													0	0	0	1	0	5	25										A	3992006	G	A	3992006	3	1	100	1	0	0	0	0	1	0	0	0	18252	1261	44	2	6850	2	ZZEF1	17	3992006	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	655137	3992006	77203204	666	31260										
ZZEF1	23140	broad.mit.edu	37	chr17	4013096	4013096	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctctgaaagccaacagccctGagaccatgaattctagtgtc	8	12	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4013096G>C	uc002fxe.2	-	6	1192	c.1128C>G	c.(1126-1128)CTC>CTG	p.L376L	ZZEF1_uc002fxk.1_Silent_p.L376L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	376	DOC.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAACAGCCCTGAGACCATGAA	0.443													0	0	0	1	0	12	43										C	4013096	G	C	4013096	2	2	100	1	0	0	0	0	0	0	0	1	18252	1277	45	1		1	ZZEF1	17	4013096	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	21090	4013096	77182114	667	31261										
UBE2G1	7326	broad.mit.edu	37	chr17	4200037	4200037	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggtgccagatttctgtaatGaatttcattttaggaggtcg	12	5	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4200037G>A	uc002fxs.2	-	3	580	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_003342	NP_003333	P62253	UB2G1_HUMAN	ubiquitin-conjugating enzyme E2G 1	74					protein K48-linked ubiquitination|protein K63-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						TTTCTGTAATGAATTTCATTT	0.348													0	0	0	1	0	126	17										A	4200037	G	A	4200037	2	1	100	1	0	0	0	0	0	0	0	1	16853	1281	45	1		1	UBE2G1	17	4200037	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	186941	4200037	76995173	668	31262										
MYBBP1A	10514	broad.mit.edu	37	chr17	4457360	4457360	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggcgagcactccaaacaggTttgcaaagagagcaggtctc	13	10	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4457360T>C	uc002fyb.3	-	4	469	c.407A>G	c.(406-408)AAC>AGC	p.N136S	MYBBP1A_uc002fxz.3_Missense_Mutation_p.N136S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	136	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						TCCAAACAGGTTTGCAAAGAG	0.592													0	0	0	1	0	47	8										C	4457360	T	C	4457360	3	2	100	1	0	0	0	0	1	0	0	0	10008	1725	60	5	3711	5	MYBBP1A	17	4457360	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	257323	4457360	76737850	669	31263										
SMTNL2	342527	broad.mit.edu	37	chr17	4498617	4498617	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgggagcaggaaacggcggcCggcaagtacggatgcccact	16	11	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4498617C>T	uc002fyf.1	+	5	1051	c.984C>T	c.(982-984)GCC>GCT	p.A328A	SMTNL2_uc002fye.2_Silent_p.A184A	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	328											0				READ - Rectum adenocarcinoma(115;0.0325)		AAACGGCGGCCGGCAAGTACG	0.677													0	0	0	1	0	3	26										T	4498617	C	T	4498617	2	4	100	1	0	0	0	0	0	0	0	1	14816	639	23	2		2	SMTNL2	17	4498617	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	41257	4498617	76696593	670	31264										
TP53	7157	broad.mit.edu	37	chr17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcctctgtgcgccggtctCtcccaggacaggcacaaaca	9	16	2	0	rs121912660		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	31	3										G	7577099	C	G	7577099	3	3	100	1	0	0	0	0	1	0	0	0	16378	913	32	1	447	1	TP53	17	7577099	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	3078482	7577099	73618111	671	31265										
PFAS	5198	broad.mit.edu	37	chr17	8157482	8157482	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccttgccctgtctccctgcAgctgaggccctccccagtgc	9	19	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:8157482A>C	uc002gkr.2	+	3	284	c.143_splice	c.e3-2	p.A48_splice	PFAS_uc010vuv.1_Splice_Site	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase						'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTCTCCCTGCAGCTGAGGCCC	0.582													0	0	0	1	0	20	16										C	8157482	A	C	8157482	5	2	100	1	0	0	0	0	0	0	1	0	11754	202	7	5	147	5	PFAS	17	8157482	Splice_Site	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	580383	8157482	73037728	672	31266										
PIK3R5	23533	broad.mit.edu	37	chr17	8808182	8808182	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggtcaggaaccggtggtaGgtgctggctgccttcagaag	16	9	2	1	rs144885920		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:8808182G>A	uc002glt.2	-	5	391	c.324C>T	c.(322-324)ACC>ACT	p.T108T	PIK3R5_uc010vuz.1_Silent_p.T108T|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Silent_p.T108T|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	108					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ACCGGTGGTAGGTGCTGGCTG	0.552													0	0	0	1	0	10	28										A	8808182	G	A	8808182	2	1	100	1	0	0	0	0	0	0	0	1	11922	987	35	2		2	PIK3R5	17	8808182	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	650700	8808182	72387028	673	31267										
MYH4	4622	broad.mit.edu	37	chr17	10362679	10362679	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcacgaacatgtggtggttGaaaaactgttgcagtttctc	11	7	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:10362679G>C	uc002gmn.2	-	15	1587	c.1476C>G	c.(1474-1476)TTC>TTG	p.F492L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	492	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGTGGTGGTTGAAAAACTGTT	0.473													0	0	0	1	0	26	64										C	10362679	G	C	10362679	3	2	100	1	0	0	0	0	1	0	0	0	10037	1281	45	1	4447	1	MYH4	17	10362679	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1554497	10362679	70832531	674	31268										
TRIM16	10626	broad.mit.edu	37	chr17	15501958	15501975	+	Splice_Site	DEL	ATCCCAGTATCTGCAGGA	ATCCCAGTATCTGCAGGA	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgcaaaccccacttttcagAtcccagtatctgcaggaatc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:15501958_15501975delATCCCAGTATCTGCAGGA	uc002gor.1	-	14	2701	c.2364_splice	c.e14-1	p.R788_splice	CDRT1_uc010vvy.1_5'UTR|CDRT1_uc010vvz.1_5'UTR|CDRT1_uc002gov.3_Splice_Site_p.R478_splice|CDRT1_uc002gou.2_Splice_Site_p.R86_splice|CDRT1_uc010cos.1_5'UTR			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;						histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		CACTTTTCAGATCCCAGTATCTGCAGGAATCAGGCCAA	0.472																		7	13	---	---								-	15501975	ATCCCAGTATCTGCAGGA	-	15501958	8	5	100	1	0	1	0	1	0	0	1	0	16488	330	12	0		0	TRIM16	17	15501958	Splice_Site	DEL	ATCCCAGTATCTGCAGGA	TCGA-G2-A3VY-01A-11D-A22Z-08	5139279	15501958	65693252	675	31269										
MYO15A	51168	broad.mit.edu	37	chr17	18045033	18045033	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacatgtgtgtgtcagtgctGagtcgcctgtgcaaagtcat	13	8	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:18045033G>C	uc010vxh.1	+	22	5936	c.5598G>C	c.(5596-5598)CTG>CTC	p.L1866L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1866	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGTCAGTGCTGAGTCGCCTGT	0.582											OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	32	28										C	18045033	G	C	18045033	2	2	100	1	0	0	0	0	0	0	0	1	10063	1277	45	1		1	MYO15A	17	18045033	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2543075	18045033	63150177	676	31270										
EPN2	22905	broad.mit.edu	37	chr17	19235231	19235231	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccctgacccctttgagtctCaacccctgactgtcgcctca	7	18	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:19235231C>G	uc002gvd.3	+	10	1925	c.1477C>G	c.(1477-1479)CAA>GAA	p.Q493E	EPN2_uc010cql.1_Missense_Mutation_p.Q202E|EPN2_uc002gve.3_Missense_Mutation_p.Q436E|EPN2_uc002gvf.3_Missense_Mutation_p.Q208E|EPN2_uc010vyo.1_Missense_Mutation_p.Q201E|EPN2_uc010vyp.1_Missense_Mutation_p.Q429E|EPN2_uc010vyq.1_Missense_Mutation_p.Q430E|EPN2_uc002gvh.1_Intron|EPN2_uc002gvj.3_Missense_Mutation_p.Q156E	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	493	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CTTTGAGTCTCAACCCCTGAC	0.572													0	0	0	1	0	33	134										G	19235231	C	G	19235231	3	3	100	1	0	0	0	0	1	0	0	0	5186	827	29	1	1507	1	EPN2	17	19235231	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1190198	19235231	61959979	677	31271										
CCDC144NL	339184	broad.mit.edu	37	chr17	20768765	20768765	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acacatgattcttcccctttCtttttcctcttgcaaagatg	4	12	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:20768765C>A	uc002gyf.2	-	4	749	c.629G>T	c.(628-630)AGA>ATA	p.R210I	uc002gyg.1_5'Flank|uc002gyh.1_5'Flank	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	210											0						CTTCCCCTTTCTTTTTCCTCT	0.368													1	0	1.60099e-16	1	1.76978e-16	36	45										A	20768765	C	A	20768765	3	1	100	1	0	0	0	0	1	0	0	0	2779	913	32	3	40	3	CCDC144NL	17	20768765	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1533534	20768765	60426445	678	31272										
CCDC144NL	339184	broad.mit.edu	37	chr17	20796765	20796765	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttccttatattcaggaactaGttgctgaatgctatggataa	8	6	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:20796765G>C	uc002gyf.2	-	2	475	c.355C>G	c.(355-357)CTA>GTA	p.L119V	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	119											0						TCAGGAACTAGTTGCTGAATG	0.249													0	0	0	1	0	33	30										C	20796765	G	C	20796765	3	2	100	1	0	0	0	0	1	0	0	0	2779	1020	36	4	322	4	CCDC144NL	17	20796765	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	28000	20796765	60398445	679	31273										
SLC13A2	9058	broad.mit.edu	37	chr17	26824194	26824194	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aacagctggggcatccccctCttcagcctgcactctttccc	7	18	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:26824194C>T	uc002hbh.2	+	12	1753	c.1686C>T	c.(1684-1686)CTC>CTT	p.L562L	SLC13A2_uc010wam.1_Silent_p.L518L|SLC13A2_uc010wan.1_Silent_p.L611L|SLC13A2_uc010wao.1_Silent_p.L519L|SLC13A2_uc002hbi.2_Silent_p.L491L	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	562	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GCATCCCCCTCTTCAGCCTGC	0.612													0	0	0	1	0	60	87										T	26824194	C	T	26824194	2	4	100	1	0	0	0	0	0	0	0	1	14392	900	32	1		1	SLC13A2	17	26824194	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	6027429	26824194	54371016	680	31274										
PHF12	57649	broad.mit.edu	37	chr17	27246266	27246266	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggagagggcaatagtcacaCtggatgagaggagccacacg	15	8	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:27246266C>G	uc002hdg.1	-	6	1394	c.864G>C	c.(862-864)CAG>CAC	p.Q288H	PHF12_uc010wbb.1_Missense_Mutation_p.Q270H|PHF12_uc002hdi.1_Missense_Mutation_p.Q284H|PHF12_uc002hdj.1_Missense_Mutation_p.Q288H|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdh.1_Missense_Mutation_p.Q71H	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	288	PHD-type 2; atypical.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			AATAGTCACACTGGATGAGAG	0.502													0	0	0	1	0	7	29										G	27246266	C	G	27246266	3	3	100	1	0	0	0	0	1	0	0	0	11823	564	20	4	2216	4	PHF12	17	27246266	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	422072	27246266	53948944	681	31275										
ABHD15	116236	broad.mit.edu	37	chr17	27893107	27893107	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggcctccgttacccacctgCtgagggcgatcttctggtgg	13	14	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:27893107C>A	uc002hed.1	-	1	942	c.878G>T	c.(877-879)AGC>ATC	p.S293I	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	293						extracellular region	carboxylesterase activity				0						TACCCACCTGCTGAGGGCGAT	0.617													1	0	1.33834e-09	1	1.42971e-09	16	49										A	27893107	C	A	27893107	3	1	100	1	0	0	0	0	1	0	0	0	81	797	28	4	536	4	ABHD15	17	27893107	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	646841	27893107	53302103	682	31276										
EFCAB5	374786	broad.mit.edu	37	chr17	28380875	28380875	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacgcagaatgtcagctgcaGaacagggatcactcagagag	12	10	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:28380875G>T	uc002het.2	+	10	2095	c.1903G>T	c.(1903-1905)GAA>TAA	p.E635*	EFCAB5_uc010wbi.1_Nonsense_Mutation_p.E378*|EFCAB5_uc010wbj.1_Nonsense_Mutation_p.E579*|EFCAB5_uc010wbk.1_Nonsense_Mutation_p.E292*|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Nonsense_Mutation_p.E514*|EFCAB5_uc010csf.2_Nonsense_Mutation_p.E514*	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	635							calcium ion binding			ovary(1)|skin(1)	2						GTCAGCTGCAGAACAGGGATC	0.443													1	0	8.04996e-18	1	8.92782e-18	23	101										T	28380875	G	T	28380875	4	4	100	1	0	0	0	0	0	1	0	0	4938	943	33	3	1941	3	EFCAB5	17	28380875	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	487768	28380875	52814335	683	31277										
NF1	4763	broad.mit.edu	37	chr17	29592283	29592283	+	Frame_Shift_Del	DEL	G	G	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaagaagaattcaaggctttGaaaacgttaagtattttcta							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:29592283delG	uc002hgg.2	+	36	5094	c.4761delG	c.(4759-4761)TTGfs	p.L1587fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L1566fs|NF1_uc002hgi.1_Frame_Shift_Del_p.L599fs|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1587	CRAL-TRIO.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(3)|p.L1587*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCAAGGCTTTGAAAACGTTAA	0.343			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)								19	105	---	---								-	29592283	G	-	29592283	7	5	100	1	0	1	0	1	0	0	0	0	10356	1281	45	0	4964	0	NF1	17	29592283	Frame_Shift_Del	DEL	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1211408	29592283	51602927	684	31278										
MYO1D	4642	broad.mit.edu	37	chr17	30986161	30986161	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatcgtctgcagggcctcctCaaaacggcgaagaactttag	10	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:30986161C>G	uc002hho.1	-	17	2329	c.2317G>C	c.(2317-2319)GAG>CAG	p.E773Q	MYO1D_uc002hhp.1_Missense_Mutation_p.E773Q	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	773						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			AGGGCCTCCTCAAAACGGCGA	0.517											OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	65										G	30986161	C	G	30986161	3	3	100	1	0	0	0	0	1	0	0	0	10071	835	29	1	727	1	MYO1D	17	30986161	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1393878	30986161	50209049	685	31279										
MYO1D	4642	broad.mit.edu	37	chr17	30986208	30986208	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttggccacttcacgtgcttcCcgtagtctcgcatggtcttg	10	13	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:30986208C>A	uc002hho.1	-	17	2282	c.2270G>T	c.(2269-2271)GGG>GTG	p.G757V	MYO1D_uc002hhp.1_Missense_Mutation_p.G757V	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	757						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CACGTGCTTCCCGTAGTCTCG	0.537											OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.85244e-09	1	1.9727e-09	23	93										A	30986208	C	A	30986208	3	1	100	1	0	0	0	0	1	0	0	0	10071	623	22	4	774	4	MYO1D	17	30986208	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	47	30986208	50209002	686	31280										
SLFN12	55106	broad.mit.edu	37	chr17	33749640	33749640	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtgcagcagtggcattcatGacttttgcagatgttatatc	10	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:33749640G>C	uc002hji.3	-	2	785	c.408C>G	c.(406-408)GTC>GTG	p.V136V	SLFN12_uc002hjj.3_Silent_p.V136V|SLFN12_uc010cts.2_Silent_p.V136V	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	136							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGCATTCATGACTTTTGCAG	0.428													0	0	0	1	0	22	54										C	33749640	G	C	33749640	2	2	100	1	0	0	0	0	0	0	0	1	14734	1277	45	1		1	SLFN12	17	33749640	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2763432	33749640	47445570	687	31281										
ACACA	31	broad.mit.edu	37	chr17	35468485	35468485	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccaatcgctcagccaagtgGatgtagactgggtccacccg	11	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:35468485G>C	uc002hnm.2	-	52	6626	c.6435C>G	c.(6433-6435)ATC>ATG	p.I2145M	ACACA_uc002hnk.2_Missense_Mutation_p.I2067M|ACACA_uc002hnl.2_Missense_Mutation_p.I2087M|ACACA_uc002hnn.2_Missense_Mutation_p.I2145M|ACACA_uc002hno.2_Missense_Mutation_p.I2182M|ACACA_uc010cuy.2_Missense_Mutation_p.I790M|ACACA_uc010wdb.1_Missense_Mutation_p.I183M|ACACA_uc010wdc.1_Missense_Mutation_p.I271M	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2145	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CAGCCAAGTGGATGTAGACTG	0.502													0	0	0	1	0	29	47										C	35468485	G	C	35468485	3	2	100	1	0	0	0	0	1	0	0	0	106	1164	41	1	625	1	ACACA	17	35468485	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1718845	35468485	45726725	688	31282										
TADA2A	6871	broad.mit.edu	37	chr17	35800675	35800675	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcactatatgaagcatttCatcaataaccctctgtttgc	5	10	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:35800675C>T	uc002hnt.2	+	6	511	c.354C>T	c.(352-354)TTC>TTT	p.F118F	TADA2A_uc002hnu.1_Silent_p.F118F|TADA2A_uc002hnv.2_Silent_p.F118F|TADA2A_uc010wdd.1_Silent_p.F118F|TADA2A_uc002hnw.2_Silent_p.F17F|TADA2A_uc010cvb.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	118	SANT.				histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TGAAGCATTTCATCAATAACC	0.458													0	0	0	1	0	12	39										T	35800675	C	T	35800675	2	4	100	1	0	0	0	0	0	0	0	1	15507	825	29	1		1	TADA2A	17	35800675	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	332190	35800675	45394535	689	31283										
SOCS7	30837	broad.mit.edu	37	chr17	36523881	36523881	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctcgttacatcctgagcctCagtttccgatcacagggtat	8	13	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:36523881C>T	uc002hqa.2	+	6	1431	c.1308C>T	c.(1306-1308)CTC>CTT	p.L436L	SOCS7_uc010cvl.2_Silent_p.L402L|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	436	Mediates interaction with SORBS3.|SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					TCCTGAGCCTCAGTTTCCGAT	0.483													0	0	0	1	0	17	42										T	36523881	C	T	36523881	2	4	100	1	0	0	0	0	0	0	0	1	14919	813	29	1		1	SOCS7	17	36523881	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	723206	36523881	44671329	690	31284										
CDK12	51755	broad.mit.edu	37	chr17	37618605	37618605	+	Frame_Shift_Del	DEL	G	G	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggccttcaaactagaccgaaGggagaacgacgaacgtcgtg							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:37618605delG	uc010cvv.2	+	1	867	c.281delG	c.(280-282)AGGfs	p.R94fs	CDK12_uc010wef.1_Frame_Shift_Del_p.R94fs|CDK12_uc002hrw.3_Frame_Shift_Del_p.R94fs	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	94					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CTAGACCGAAGGGAGAACGAC	0.522										TCGA Ovarian(9;0.13)								10	53	---	---								-	37618605	G	-	37618605	7	5	100	1	0	1	0	1	0	0	0	0	3128	1000	35	0	283	0	CDK12	17	37618605	Frame_Shift_Del	DEL	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1094724	37618605	43576605	691	31285										
IKZF3	22806	broad.mit.edu	37	chr17	37949123	37949123	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctcttctgcatttcccatgGgttctgactttaaaacattc	6	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:37949123G>A	uc002hsu.2	-	4	289	c.227C>T	c.(226-228)CCC>CTC	p.P76L	IKZF3_uc002htd.2_Missense_Mutation_p.P42L|IKZF3_uc010cwd.2_Intron|IKZF3_uc002hsv.2_Missense_Mutation_p.P42L|IKZF3_uc010cwe.2_Missense_Mutation_p.P76L|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Missense_Mutation_p.P76L|IKZF3_uc002hsx.2_Missense_Mutation_p.P76L|IKZF3_uc002hsy.2_Missense_Mutation_p.P76L|IKZF3_uc002hsz.2_Missense_Mutation_p.P76L|IKZF3_uc002hta.2_Missense_Mutation_p.P76L|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Intron|IKZF3_uc002htc.2_5'UTR	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	76					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATTTCCCATGGGTTCTGACTT	0.353													0	0	0	1	0	29	47										A	37949123	G	A	37949123	3	1	100	1	0	0	0	0	1	0	0	0	7616	1232	43	2	1322	2	IKZF3	17	37949123	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	330518	37949123	43246087	692	31286										
CNP	1267	broad.mit.edu	37	chr17	40123969	40123969	+	Frame_Shift_Del	DEL	C	C	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcacctactttggaaagagaCccccaggcgtgctgcattgc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:40123969delC	uc002hyl.1	+	3	880	c.736delC	c.(736-738)CCCfs	p.P246fs	CNP_uc010wfz.1_Frame_Shift_Del_p.P123fs|CNP_uc002hym.1_Frame_Shift_Del_p.P226fs|CNP_uc010wga.1_Frame_Shift_Del_p.P11fs|CNP_uc002hyn.1_Frame_Shift_Del_p.P11fs	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	246					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		TGGAAAGAGACCCCCAGGCGT	0.592																		16	36	---	---								-	40123969	C	-	40123969	7	5	100	1	0	1	0	1	0	0	0	0	3626	507	18	0	746	0	CNP	17	40123969	Frame_Shift_Del	DEL	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2174846	40123969	41071241	693	31287										
HCRT	3060	broad.mit.edu	37	chr17	40336367	40336367	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggggcccggacctccgcttGcccagcgtgaggatgccggc	17	15	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:40336367G>C	uc002hzc.1	-	2	288	c.201C>G	c.(199-201)GGC>GGG	p.G67G		NM_001524	NP_001515	O43612	OREX_HUMAN	orexin precursor	67					neuropeptide signaling pathway	cell junction|extracellular region|rough endoplasmic reticulum|synaptic vesicle					0		all_cancers(22;1.39e-06)|all_epithelial(22;9.98e-06)|Breast(137;0.000143)|Ovarian(249;0.0221)|Myeloproliferative disorder(1115;0.0255)|Colorectal(1115;0.069)		BRCA - Breast invasive adenocarcinoma(366;0.124)		ACCTCCGCTTGCCCAGCGTGA	0.726													0	0	0	1	0	6	4										C	40336367	G	C	40336367	2	2	100	1	0	0	0	0	0	0	0	1	7000	1306	46	4		4	HCRT	17	40336367	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	212398	40336367	40858843	694	31288										
DBF4B	80174	broad.mit.edu	37	chr17	42828010	42828010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcgatggacagaatcactaGatggtgtgatgggacctcct	13	8	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:42828010G>C	uc002ihf.2	+	14	1450	c.1237G>C	c.(1237-1239)GAT>CAT	p.D413H	DBF4B_uc010wjc.1_Missense_Mutation_p.D397H	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	413					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				AGAATCACTAGATGGTGTGAT	0.607													0	0	0	1	0	13	40										C	42828010	G	C	42828010	3	2	100	1	0	0	0	0	1	0	0	0	4249	942	33	1	1336	1	DBF4B	17	42828010	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2491643	42828010	38367200	695	31289										
KIAA1267	284058	broad.mit.edu	37	chr17	44159875	44159875	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaataagtctgttgtatgctCtgggggaggtacctccccaa	11	9	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:44159875C>G	uc002ikb.2	-	3	1550	c.1465G>C	c.(1465-1467)GAG>CAG	p.E489Q	KIAA1267_uc002ikc.2_Missense_Mutation_p.E489Q|KIAA1267_uc002ikd.2_Missense_Mutation_p.E489Q|KIAA1267_uc010dav.2_Missense_Mutation_p.E489Q	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	489						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				GTTGTATGCTCTGGGGGAGGT	0.398													0	0	0	1	0	28	27										G	44159875	C	G	44159875	3	3	100	1	0	0	0	0	1	0	0	0	8219	922	32	1	1900	1	KIAA1267	17	44159875	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1331865	44159875	37035335	696	31290										
COPZ2	51226	broad.mit.edu	37	chr17	46111232	46111232	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagagggggacacttactctCagtccggctggtcttgttga	13	9	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:46111232C>T	uc002imy.2	-	7	278	c.265G>A	c.(265-267)GAG>AAG	p.E89K		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CACTTACTCTCAGTCCGGCTG	0.483													0	0	0	1	0	7	5										T	46111232	C	T	46111232	3	4	100	1	0	0	0	0	1	0	0	0	3742	835	29	1	395	1	COPZ2	17	46111232	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1951357	46111232	35083978	697	31291										
XYLT2	64132	broad.mit.edu	37	chr17	48431301	48431301	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agatacagggagcgtggaggGcgccccccagcccacggaca	15	14	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:48431301G>T	uc002iqo.2	+	2	555	c.446G>T	c.(445-447)GGC>GTC	p.G149V	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	149	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AGCGTGGAGGGCGCCCCCCAG	0.687													1	0	4.68919e-08	1	4.947e-08	9	28										T	48431301	G	T	48431301	3	4	100	1	0	0	0	0	1	0	0	0	17461	1203	42	4	452	4	XYLT2	17	48431301	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2320069	48431301	32763909	698	31292										
EPN3	55040	broad.mit.edu	37	chr17	48616645	48616645	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agagcctgagagagaagagaGaaaggaggaggagaagctaa	17	3	0	6			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:48616645G>C	uc002ira.3	+	5	1295	c.860G>C	c.(859-861)AGA>ACA	p.R287T	EPN3_uc010wms.1_Missense_Mutation_p.R315T|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.R260T	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	287						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGAGAAGAGAGAAAGGAGGAG	0.542													0	0	0	1	0	10	36										C	48616645	G	C	48616645	3	2	100	1	0	0	0	0	1	0	0	0	5187	942	33	1	874	1	EPN3	17	48616645	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	185344	48616645	32578565	699	31293										
TEX14	56155	broad.mit.edu	37	chr17	56693643	56693643	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agagatcctagataggccatCtgtgtcgccccagtaagata	10	10	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:56693643C>G	uc010dcz.1	-	7	796	c.678G>C	c.(676-678)CAG>CAC	p.Q226H	TEX14_uc002iwr.1_Missense_Mutation_p.Q220H|TEX14_uc002iws.1_Missense_Mutation_p.Q220H|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	226						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATAGGCCATCTGTGTCGCCC	0.478													0	0	0	1	0	10	66										G	56693643	C	G	56693643	3	3	100	1	0	0	0	0	1	0	0	0	15775	912	32	1	3923	1	TEX14	17	56693643	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	8076998	56693643	24501567	700	31294										
CLTC	1213	broad.mit.edu	37	chr17	57743482	57743482	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agattgtagatgtctttatgGaatacaatctaattcagcag	8	5	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:57743482G>A	uc002ixq.1	+	11	2106	c.1663G>A	c.(1663-1665)GAA>AAA	p.E555K	CLTC_uc002ixp.2_Missense_Mutation_p.E555K|CLTC_uc002ixr.1_Missense_Mutation_p.E559K	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	555	Heavy chain arm.|Distal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGTCTTTATGGAATACAATCT	0.333			T	ALK|TFE3	ALCL|renal 								0	0	0	1	0	9	26										A	57743482	G	A	57743482	3	1	100	1	0	0	0	0	1	0	0	0	3566	1175	41	1	1705	1	CLTC	17	57743482	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1049839	57743482	23451728	701	31295										
TBX4	9496	broad.mit.edu	37	chr17	59560332	59560332	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctcttcggtgggggaggatCactatttccgttccccccct	10	15	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:59560332C>T	uc002izi.2	+	8	1138	c.1093C>T	c.(1093-1095)CAC>TAC	p.H365Y	TBX4_uc010ddo.2_Missense_Mutation_p.H366Y|TBX4_uc010woy.1_Missense_Mutation_p.H366Y	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	365					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GGGGGAGGATCACTATTTCCG	0.552													0	0	0	1	0	9	26										T	59560332	C	T	59560332	3	4	100	1	0	0	0	0	1	0	0	0	15657	826	29	1	1123	1	TBX4	17	59560332	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1816850	59560332	21634878	702	31296										
TANC2	26115	broad.mit.edu	37	chr17	61488930	61488930	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccctcagctgggcttgtttGaagggccatctctcagtagt	12	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:61488930G>A	uc002jal.3	+	20	3449	c.3426G>A	c.(3424-3426)TTG>TTA	p.L1142L	TANC2_uc010wpe.1_Silent_p.L1052L|TANC2_uc002jao.3_Silent_p.L243L	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1142	ANK 9.						binding			ovary(2)	2						GGGCTTGTTTGAAGGGCCATC	0.527													0	0	0	1	0	23	66										A	61488930	G	A	61488930	2	1	100	1	0	0	0	0	0	0	0	1	15542	1281	45	1		1	TANC2	17	61488930	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1928598	61488930	19706280	703	31297										
ABCA9	10350	broad.mit.edu	37	chr17	67023212	67023212	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gattccatattcggtgccttGaaagaggatccaatccagca	9	10	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:67023212G>C	uc002jhu.2	-	15	2098	c.1955C>G	c.(1954-1956)TCA>TGA	p.S652*	ABCA9_uc010dez.2_Nonsense_Mutation_p.S652*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	652	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCGGTGCCTTGAAAGAGGATC	0.438													0	0	0	1	0	24	46										C	67023212	G	C	67023212	4	2	100	1	0	0	0	0	0	1	0	0	39	1294	45	1	3019	1	ABCA9	17	67023212	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5534282	67023212	14171998	704	31298										
C17orf80	55028	broad.mit.edu	37	chr17	71231891	71231891	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacaaaccagaacagacagtGaagacctttccactgccagc	8	13	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:71231891G>T	uc002jjm.3	+	3	464	c.270G>T	c.(268-270)GTG>GTT	p.V90V	C17orf80_uc010wqu.1_Silent_p.V90V|C17orf80_uc010dfj.2_Silent_p.V90V|C17orf80_uc002jjk.1_Silent_p.V90V|C17orf80_uc002jjl.3_Silent_p.V90V	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	lung cancer-related protein 8 isoform a	90	Extracellular (Potential).					integral to membrane				skin(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			AACAGACAGTGAAGACCTTTC	0.388													1	0	5.03518e-11	1	5.42456e-11	19	36										T	71231891	G	T	71231891	2	4	100	1	0	0	0	0	0	0	0	1	1885	1277	45	3		3	C17orf80	17	71231891	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	4208679	71231891	9963319	705	31299										
KIF19	124602	broad.mit.edu	37	chr17	72350300	72350300	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gttccccgtgtcccgctgcaGagaggaaggagatcctgact	13	12	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:72350300G>C	uc002jkm.3	+	18	2447	c.2309_splice	c.e18-1	p.E770_splice		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TCCCGCTGCAGAGAGGAAGGA	0.587													0	0	0	1	0	21	76										C	72350300	G	C	72350300	5	2	100	1	0	0	0	0	0	0	1	0	8282	956	33	1	2378	1	KIF19	17	72350300	Splice_Site	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1118409	72350300	8844910	706	31300										
GPR142	350383	broad.mit.edu	37	chr17	72366737	72366737	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agtttgaaagccactggccaGagatcgcagagaggtccccg	13	11	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:72366737G>C	uc010wqy.1	+	3	436	c.436G>C	c.(436-438)GAG>CAG	p.E146Q	GPR142_uc010wqx.1_Missense_Mutation_p.E58Q	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	146	Extracellular (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCACTGGCCAGAGATCGCAGA	0.647													0	0	0	1	0	15	33										C	72366737	G	C	72366737	3	2	100	1	0	0	0	0	1	0	0	0	6650	943	33	1	446	1	GPR142	17	72366737	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	16437	72366737	8828473	707	31301										
KIAA0195	9772	broad.mit.edu	37	chr17	73491026	73491026	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggctggaactgccacatctCcctcacacccaatggtgaca	8	15	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:73491026C>G	uc002jnz.3	+	20	2914	c.2639C>G	c.(2638-2640)TCC>TGC	p.S880C	KIAA0195_uc010wsa.1_Missense_Mutation_p.S890C|KIAA0195_uc010wsb.1_Missense_Mutation_p.S520C|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	880					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGCCACATCTCCCTCACACCC	0.582													0	0	0	1	0	36	80										G	73491026	C	G	73491026	3	3	100	1	0	0	0	0	1	0	0	0	8160	855	30	1	2713	1	KIAA0195	17	73491026	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1124289	73491026	7704184	708	31302										
H3F3B	3021	broad.mit.edu	37	chr17	73775024	73775024	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgataacgacgaatctctCgaagcgccacggtcccgggc	11	14	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:73775024C>G	uc002jpl.2	-	3	282	c.149G>C	c.(148-150)CGA>CCA	p.R50P		NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	50					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			ovary(1)	1	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAATCTCTCGAAGCGCCAC	0.652											OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	35										G	73775024	C	G	73775024	3	3	100	1	0	0	0	0	1	0	0	0	6934	884	31	1	269	1	H3F3B	17	73775024	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	283998	73775024	7420186	709	31303										
UNC13D	201294	broad.mit.edu	37	chr17	73830498	73830498	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgcagcgtgttctgcagctGcccctgctccagcacggccc	11	17	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:73830498G>A	uc002jpp.2	-	23	2586	c.2206C>T	c.(2206-2208)CAG>TAG	p.Q736*	UNC13D_uc010wsk.1_Nonsense_Mutation_p.Q736*|UNC13D_uc002jpq.1_Nonsense_Mutation_p.Q386*	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	736					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTCTGCAGCTGCCCCTGCTCC	0.692									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	1	0	10	3										A	73830498	G	A	73830498	4	1	100	1	0	0	0	0	0	1	0	0	16984	1328	46	2	1106	2	UNC13D	17	73830498	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	55474	73830498	7364712	710	31304										
QRICH2	84074	broad.mit.edu	37	chr17	74274098	74274098	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagggggagcccaggcactGggcgtgcagcagctcgcgga	19	12	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:74274098G>C	uc002jrd.1	-	15	4771	c.4591C>G	c.(4591-4593)CAG>GAG	p.Q1531E	QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Missense_Mutation_p.Q375E	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1531							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCCAGGCACTGGGCGTGCAGC	0.627													0	0	0	1	0	24	71										C	74274098	G	C	74274098	3	2	100	1	0	0	0	0	1	0	0	0	12880	1357	47	4	420	4	QRICH2	17	74274098	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	443600	74274098	6921112	711	31305										
EIF4A3	9775	broad.mit.edu	37	chr17	78111251	78111251	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggggcatgtctccatgcattGaggatacagtgaagttggct	14	7	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:78111251G>C	uc010wuc.1	-	10	990	c.917C>G	c.(916-918)TCA>TGA	p.S306*	EIF4A3_uc002jxs.2_Nonsense_Mutation_p.S306*	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	306	Helicase C-terminal.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TCCATGCATTGAGGATACAGT	0.532													0	0	0	1	0	12	15										C	78111251	G	C	78111251	4	2	100	1	0	0	0	0	0	1	0	0	5026	1294	45	1	334	1	EIF4A3	17	78111251	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3837153	78111251	3083959	712	31306										
PYCR1	5831	broad.mit.edu	37	chr17	79893381	79893381	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgttgtggggtgtcaacttCacccccatcttctgcagggg	12	11	4	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:79893381C>T	uc002kcr.1	-	3	428	c.150G>A	c.(148-150)GTG>GTA	p.V50V	PYCR1_uc002kcq.1_Silent_p.V50V|PYCR1_uc002kcp.2_Silent_p.V50V|PYCR1_uc002kcs.1_Silent_p.V50V|PYCR1_uc010wvd.1_Silent_p.V77V|PYCR1_uc002kct.1_Silent_p.V50V|PYCR1_uc002kcu.1_Silent_p.V50V|PYCR1_uc010wve.1_Silent_p.V3V	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	50					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	GTGTCAACTTCACCCCCATCT	0.582													0	0	0	1	0	6	16										T	79893381	C	T	79893381	2	4	100	1	0	0	0	0	0	0	0	1	12855	813	29	1		1	PYCR1	17	79893381	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1782130	79893381	1301829	713	31307										
CLUL1	27098	broad.mit.edu	37	chr18	641518	641518	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caaaccaggccccagaaacaGagatcatctttaattcaata	5	11	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:641518G>C	uc002kkp.2	+	7	1331	c.1186G>C	c.(1186-1188)GAG>CAG	p.E396Q	CLUL1_uc010wys.1_Missense_Mutation_p.E448Q|CLUL1_uc002kkq.2_Missense_Mutation_p.E396Q	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	396					cell death	extracellular region				ovary(2)	2						CCCAGAAACAGAGATCATCTT	0.458													0	0	0	1	0	20	29										C	641518	G	C	641518	3	2	100	1	0	0	0	0	1	0	0	0	3570	943	33	1	1208	1	CLUL1	18	641518	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		641518	77435730	714	31308										
MYOM1	8736	broad.mit.edu	37	chr18	3129355	3129355	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcacttctgtttggcccaggTtttgagagctactgggtagt	12	8	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:3129355T>A	uc002klp.2	-	18	3003	c.2669A>T	c.(2668-2670)AAC>ATC	p.N890I	MYOM1_uc002klq.2_Intron	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	890						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTGGCCCAGGTTTTGAGAGCT	0.522											OREG0024838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	39	122										A	3129355	T	A	3129355	3	1	100	1	0	0	0	0	1	0	0	0	10091	1725	60	5	2472	5	MYOM1	18	3129355	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	2487837	3129355	74947893	715	31309										
RAB12	201475	broad.mit.edu	37	chr18	8624969	8624969	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatcaaaactgtagagctaaGaggaaagaaaattagattac	8	4	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:8624969G>C	uc002knp.2	+	2	543	c.260G>C	c.(259-261)AGA>ACA	p.R87T		NM_001025300	NP_001020471	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	87					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0						GTAGAGCTAAGAGGAAAGAAA	0.333													0	0	0	1	0	31	130										C	8624969	G	C	8624969	3	2	100	1	0	0	0	0	1	0	0	0	12898	942	33	1	266	1	RAB12	18	8624969	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5495614	8624969	69452279	716	31310										
KIAA0802	23255	broad.mit.edu	37	chr18	8793020	8793020	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggggcccccccgttttacctGagcagagtgtatccatagag	12	12	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:8793020G>C	uc002knr.2	+	8	2054	c.1912G>C	c.(1912-1914)GAG>CAG	p.E638Q	KIAA0802_uc002knq.2_Intron|KIAA0802_uc002kns.2_Intron	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						CGTTTTACCTGAGCAGAGTGT	0.527													0	0	0	1	0	40	130										C	8793020	G	C	8793020	3	2	100	1	0	0	0	0	1	0	0	0	8194	1291	45	1	1934	1	KIAA0802	18	8793020	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	168051	8793020	69284228	717	31311										
SEH1L	81929	broad.mit.edu	37	chr18	12948141	12948141	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgtttgtggctcgcagcatCgcggcggaccacaaggatct	13	11	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:12948141C>T	uc002krr.2	+	1	159	c.21C>T	c.(19-21)ATC>ATT	p.I7I	SEH1L_uc002krq.2_Silent_p.I7I	NM_031216	NP_112493	Q96EE3	SEH1_HUMAN	sec13-like protein isoform 2	7					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex					0						CTCGCAGCATCGCGGCGGACC	0.672													0	0	0	1	0	7	14										T	12948141	C	T	12948141	2	4	100	1	0	0	0	0	0	0	0	1	14009	874	31	1		1	SEH1L	18	12948141	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4155121	12948141	65129107	718	31312										
IMPACT	55364	broad.mit.edu	37	chr18	22008854	22008854	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgatgctgccgaatgaatacCcaggtacagctccacctatc	8	13	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:22008854C>G	uc002kvh.3	+	3	299	c.187C>G	c.(187-189)CCA>GCA	p.P63A	IMPACT_uc002kvg.3_Missense_Mutation_p.P45A	NM_018439	NP_060909	Q9P2X3	IMPCT_HUMAN	Impact homolog	63	RWD.										0	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					GAATGAATACCCAGGTACAGC	0.353													0	0	0	1	0	12	48										G	22008854	C	G	22008854	3	3	100	1	0	0	0	0	1	0	0	0	7724	623	22	4	197	4	IMPACT	18	22008854	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	9060713	22008854	56068394	719	31313										
MYO5B	4645	broad.mit.edu	37	chr18	47404156	47404156	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacctgctggagggcatcctCagtgtctccgatctcagatg	11	13	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:47404156C>T	uc002leb.2	-	25	3661	c.3373G>A	c.(3373-3375)GAG>AAG	p.E1125K	MYO5B_uc002lea.2_Missense_Mutation_p.E266K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1125	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGGGCATCCTCAGTGTCTCCG	0.512													0	0	0	1	0	53	28										T	47404156	C	T	47404156	3	4	100	1	0	0	0	0	1	0	0	0	10079	835	29	1	2237	1	MYO5B	18	47404156	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	25395302	47404156	30673092	720	31314										
SERPINB2	5055	broad.mit.edu	37	chr18	61570328	61570328	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttctcagggatgtcggagaGgaatgacctgtttctttctg	12	7	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:61570328G>A	uc010xeu.1	+	9	1370	c.1037G>A	c.(1036-1038)AGG>AAG	p.R346K	SERPINB2_uc002ljo.2_Missense_Mutation_p.R346K|SERPINB2_uc010dqh.2_Missense_Mutation_p.R276K|SERPINB2_uc002ljp.1_Intron|SERPINB2_uc002ljq.1_Intron	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	346					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	ATGTCGGAGAGGAATGACCTG	0.507													0	0	0	1	0	8	28										A	61570328	G	A	61570328	3	1	100	1	0	0	0	0	1	0	0	0	14101	1000	35	2	1063	2	SERPINB2	18	61570328	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	14166172	61570328	16506920	721	31315										
CDH7	1005	broad.mit.edu	37	chr18	63526160	63526160	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agacactgtcttatttattaGagaatccatctcaagtagga	7	7	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:63526160G>C	uc002ljz.2	+	9	1698	c.1373_splice	c.e9-1	p.Q458_splice	CDH7_uc002lka.2_Splice_Site_p.Q458_splice|CDH7_uc002lkb.2_Splice_Site_p.Q458_splice	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TTATTTATTAGAGAATCCATC	0.373													0	0	0	1	0	13	20										C	63526160	G	C	63526160	5	2	100	1	0	0	0	0	0	0	1	0	3115	956	33	1	1402	1	CDH7	18	63526160	Splice_Site	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1955832	63526160	14551088	722	31316										
NETO1	81832	broad.mit.edu	37	chr18	70532056	70532056	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccttaccttctatgatgtaGatgcattcccggtcaggggg	11	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:70532056G>C	uc002lkw.2	-	3	491	c.207C>G	c.(205-207)ATC>ATG	p.I69M	NETO1_uc002lkx.1_Missense_Mutation_p.I68M|NETO1_uc002lky.1_Missense_Mutation_p.I69M|NETO1_uc002lkz.2_Missense_Mutation_p.I68M	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	69	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CTATGATGTAGATGCATTCCC	0.473													0	0	0	1	0	17	36										C	70532056	G	C	70532056	3	2	100	1	0	0	0	0	1	0	0	0	10339	932	33	1	1435	1	NETO1	18	70532056	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7005896	70532056	7545192	723	31317										
CNDP1	84735	broad.mit.edu	37	chr18	72226648	72226648	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcagaatgatggccgtggctGcggacacgctgcagcgcctg	15	12	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:72226648G>T	uc002llq.2	+	3	455	c.244G>T	c.(244-246)GCG>TCG	p.A82S	uc002llr.2_RNA	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	82					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GGCCGTGGCTGCGGACACGCT	0.622													1	0	0.000602214	1	0.000612452	5	51										T	72226648	G	T	72226648	3	4	100	1	0	0	0	0	1	0	0	0	3593	1319	46	4	254	4	CNDP1	18	72226648	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1694592	72226648	5850600	724	31318										
ZNF407	55628	broad.mit.edu	37	chr18	72345042	72345042	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggaagaacctctgaagtcCagggtaagccatggtaatga	12	8	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:72345042C>A	uc002llw.2	+	1	2124	c.2067C>A	c.(2065-2067)TCC>TCA	p.S689S	ZNF407_uc010xfc.1_Silent_p.S689S|ZNF407_uc010dqu.1_Silent_p.S689S|ZNF407_uc002llu.2_Silent_p.S688S	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	689					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CTCTGAAGTCCAGGGTAAGCC	0.398													1	0	6.40141e-05	1	6.58264e-05	11	33										A	72345042	C	A	72345042	2	1	100	1	0	0	0	0	0	0	0	1	17884	581	21	4		4	ZNF407	18	72345042	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	118394	72345042	5732206	725	31319										
PTBP1	5725	broad.mit.edu	37	chr19	804643	804643	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgatggccgggcagagccccGtgctcaggatcatcgtggag	16	12	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:804643G>A	uc002lpr.2	+	6	653	c.547G>A	c.(547-549)GTG>ATG	p.V183M	PTBP1_uc002lpp.2_Missense_Mutation_p.V183M|PTBP1_uc002lpq.2_Missense_Mutation_p.V183M|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Missense_Mutation_p.V153M	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	183					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGAGCCCCGTGCTCAGGAT	0.677													0	0	0	1	0	18	25										A	804643	G	A	804643	3	1	100	1	0	0	0	0	1	0	0	0	12725	1145	40	2	569	2	PTBP1	19	804643	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		804643	58324340	726	31320										
KLF16	83855	broad.mit.edu	37	chr19	1863162	1863162	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cggcgccgggggcgcggcccGaggacggggacgaggcggct	23	13	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:1863162G>C	uc002luc.2	-	1	403	c.335C>G	c.(334-336)TCG>TGG	p.S112W	KLF16_uc010xgt.1_RNA	NM_031918	NP_114124	Q9BXK1	KLF16_HUMAN	BTE-binding protein 4	112	Ser-rich.|Ala/Pro-rich.					nucleus	DNA binding|zinc ion binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ggcgcggcccgaggacgggga	0.448													0	0	0	1	0	2	0										C	1863162	G	C	1863162	3	2	100	1	0	0	0	0	1	0	0	0	8344	1059	37	1	431	1	KLF16	19	1863162	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1058519	1863162	57265821	727	31321										
DOT1L	84444	broad.mit.edu	37	chr19	2217074	2217074	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gccttgcagcttgctggagaGaagagcagtgagaaggtgcg	17	7	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:2217074G>C	uc002lvb.3	+	21	2565	c.2529G>C	c.(2527-2529)GAG>GAC	p.E843D	DOT1L_uc002lvc.1_Missense_Mutation_p.E137D|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Missense_Mutation_p.E137D	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	843						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGCTGGAGAGAAGAGCAGTG	0.687													0	0	0	1	0	6	16										C	2217074	G	C	2217074	3	2	100	1	0	0	0	0	1	0	0	0	4709	933	33	1	2611	1	DOT1L	19	2217074	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	353912	2217074	56911909	728	31322										
DPP9	91039	broad.mit.edu	37	chr19	4689638	4689638	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtgaggcgtacgatctcgcCggccgcctcatagctgacca	13	14	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:4689638C>T	uc002mba.2	-	15	1951	c.1693G>A	c.(1693-1695)GGC>AGC	p.G565S		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	536					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		ACGATCTCGCCGGCCGCCTCA	0.652													0	0	0	1	0	2	2										T	4689638	C	T	4689638	3	4	100	1	0	0	0	0	1	0	0	0	4733	652	23	2	1017	2	DPP9	19	4689638	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	2472564	4689638	54439345	729	31323										
RANBP3	8498	broad.mit.edu	37	chr19	5927994	5927994	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cataccttaactctgtccctCaagttctgcccaaatacaaa	3	14	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:5927994C>G	uc002mdw.2	-	9	1025	c.798G>C	c.(796-798)TTG>TTC	p.L266F	RANBP3_uc002mdv.2_5'UTR|RANBP3_uc002mdx.2_Missense_Mutation_p.L261F|RANBP3_uc002mdy.2_Missense_Mutation_p.L198F|RANBP3_uc002mdz.2_Missense_Mutation_p.L193F|RANBP3_uc010duq.2_Missense_Mutation_p.L171F|RANBP3_uc002mea.2_Missense_Mutation_p.L133F|RANBP3_uc010xix.1_Missense_Mutation_p.L138F	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	266					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						CTCTGTCCCTCAAGTTCTGCC	0.463													0	0	0	1	0	74	55										G	5927994	C	G	5927994	3	3	100	1	0	0	0	0	1	0	0	0	13029	825	29	1	941	1	RANBP3	19	5927994	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1238356	5927994	53200989	730	31324										
TUBB4	10382	broad.mit.edu	37	chr19	6495749	6495749	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaaagggaaccatgttgacgGccagcttgcgcaggtcggcg	16	10	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:6495749G>C	uc002mfg.1	-	4	868	c.761C>G	c.(760-762)GCC>GGC	p.A254G	TUBB4_uc002mff.1_Missense_Mutation_p.A182G|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	254					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CATGTTGACGGCCAGCTTGCG	0.682													0	0	0	1	0	18	110										C	6495749	G	C	6495749	3	2	100	1	0	0	0	0	1	0	0	0	16755	1203	42	4	577	4	TUBB4	19	6495749	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	567755	6495749	52633234	731	31325										
TNFSF14	8740	broad.mit.edu	37	chr19	6665079	6665079	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgctgtcccaccagacccggGagctgctggtggcccgtccg	14	16	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:6665079G>A	uc002mfk.1	-	5	963	c.581C>T	c.(580-582)TCC>TTC	p.S194F	TNFSF14_uc002mfj.1_Missense_Mutation_p.S158F	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	194	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CCAGACCCGGGAGCTGCTGGT	0.657													0	0	0	1	0	26	56										A	6665079	G	A	6665079	3	1	100	1	0	0	0	0	1	0	0	0	16304	1174	41	1	145	1	TNFSF14	19	6665079	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	169330	6665079	52463904	732	31326										
PNPLA6	10908	broad.mit.edu	37	chr19	7615490	7615490	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcagtggcaagaaggagctGgtgggcgagtacggccgcgg	21	8	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:7615490G>A	uc010xjq.1	+	18	2256	c.2061G>A	c.(2059-2061)CTG>CTA	p.L687L	PNPLA6_uc002mgq.1_Silent_p.L639L|PNPLA6_uc010xjp.1_Silent_p.L613L|PNPLA6_uc002mgr.1_Silent_p.L639L|PNPLA6_uc002mgs.2_Silent_p.L678L	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	678	Cytoplasmic (Potential).|cNMP 3.				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						AGAAGGAGCTGGTGGGCGAGT	0.662													0	0	0	1	0	17	22										A	7615490	G	A	7615490	2	1	100	1	0	0	0	0	0	0	0	1	12169	1335	47	2		2	PNPLA6	19	7615490	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	950411	7615490	51513493	733	31327										
OR2Z1	284383	broad.mit.edu	37	chr19	8841489	8841489	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctcttctccctggtggctgtCatgtttgtcataggccttct	9	12	5	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:8841489C>T	uc010xkg.1	+	1	99	c.99C>T	c.(97-99)GTC>GTT	p.V33V		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						TGGTGGCTGTCATGTTTGTCA	0.552													0	0	0	1	0	36	66										T	8841489	C	T	8841489	2	4	100	1	0	0	0	0	0	0	0	1	11036	813	29	1		1	OR2Z1	19	8841489	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1225999	8841489	50287494	734	31328										
MUC16	94025	broad.mit.edu	37	chr19	8969428	8969428	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ataaactgatgactccatttCtagaattaaaaaaaaagtat	4	5	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:8969428C>G	uc002mkp.2	-	79	43121	c.42917_splice	c.e79-1	p.E14306_splice	MUC16_uc010dwi.2_Splice_Site|MUC16_uc010dwj.2_Splice_Site_p.E1106_splice|MUC16_uc010xki.1_Splice_Site	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACTCCATTTCTAGAATTAAA	0.403													0	0	0	1	0	24	16										G	8969428	C	G	8969428	5	3	100	1	0	0	0	0	0	0	1	0	9973	927	32	1	631	1	MUC16	19	8969428	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	127939	8969428	50159555	735	31329										
MUC16	94025	broad.mit.edu	37	chr19	9083460	9083460	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcctgtggttagtggcatCacagatgccctctcaagccc	9	14	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:9083460C>G	uc002mkp.2	-	1	8559	c.8355G>C	c.(8353-8355)GTG>GTC	p.V2785V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2785	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTAGTGGCATCACAGATGCCC	0.502													0	0	0	1	0	8	40										G	9083460	C	G	9083460	2	3	100	1	0	0	0	0	0	0	0	1	9973	813	29	1		1	MUC16	19	9083460	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	114032	9083460	50045523	736	31330										
TYK2	7297	broad.mit.edu	37	chr19	10476364	10476364	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcggcctgggccagcagcctCaggtggcacacgggcacacg	15	15	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:10476364C>G	uc002moc.3	-	7	1218	c.840G>C	c.(838-840)CTG>CTC	p.L280L	TYK2_uc010dxe.2_Silent_p.L95L|TYK2_uc002mod.2_Silent_p.L280L	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	280	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCAGCAGCCTCAGGTGGCACA	0.687													0	0	0	1	0	16	30										G	10476364	C	G	10476364	2	3	100	1	0	0	0	0	0	0	0	1	16807	813	29	1		1	TYK2	19	10476364	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1392904	10476364	48652619	737	31331										
TYK2	7297	broad.mit.edu	37	chr19	10478979	10478979	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtctccacccaccttatgcgGaaatatagcatcaggcttgc	8	13	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:10478979G>A	uc002moc.3	-	4	687	c.309C>T	c.(307-309)TTC>TTT	p.F103F	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.F103F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	103	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ACCTTATGCGGAAATATAGCA	0.557													0	0	0	1	0	76	92										A	10478979	G	A	10478979	2	1	100	1	0	0	0	0	0	0	0	1	16807	1165	41	1		1	TYK2	19	10478979	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2615	10478979	48650004	738	31332										
DNM2	1785	broad.mit.edu	37	chr19	10930726	10930726	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtggagaagggcttcatgtCcaacaagcacgtcttcgcca	11	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:10930726C>T	uc002mps.1	+	16	1906	c.1742C>T	c.(1741-1743)TCC>TTC	p.S581F	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.S581F|DNM2_uc002mpv.1_Missense_Mutation_p.S577F|DNM2_uc002mpu.1_Missense_Mutation_p.S577F|DNM2_uc010dxl.1_Missense_Mutation_p.S581F|DNM2_uc002mpw.2_Missense_Mutation_p.S310F|uc010xlj.1_5'Flank|MIR199A1_hsa-mir-199a-1|MI0000242_5'Flank	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	581	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GGCTTCATGTCCAACAAGCAC	0.562													0	0	0	1	0	32	103										T	10930726	C	T	10930726	3	4	100	1	0	0	0	0	1	0	0	0	4672	855	30	1	1947	1	DNM2	19	10930726	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	451747	10930726	48198257	739	31333										
SMARCA4	6597	broad.mit.edu	37	chr19	11138491	11138491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accgagcctcgggtaaatttGagcttcttgatagaattctt	9	8	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:11138491G>A	uc002mqf.3	+	24	3531	c.3247G>A	c.(3247-3249)GAG>AAG	p.E1083K	SMARCA4_uc010dxp.2_Missense_Mutation_p.E1083K|SMARCA4_uc010dxo.2_Missense_Mutation_p.E1083K|SMARCA4_uc002mqg.1_Missense_Mutation_p.E1083K|SMARCA4_uc010dxq.2_Missense_Mutation_p.E1083K|SMARCA4_uc010dxr.2_Missense_Mutation_p.E1083K|SMARCA4_uc002mqj.3_Missense_Mutation_p.E1083K|SMARCA4_uc010dxs.2_Missense_Mutation_p.E1083K|SMARCA4_uc010dxt.1_Missense_Mutation_p.E303K|SMARCA4_uc002mqh.3_Missense_Mutation_p.E206K|SMARCA4_uc002mqi.1_Missense_Mutation_p.E286K	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1083					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGGTAAATTTGAGCTTCTTGA	0.517			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	1	0	64	66										A	11138491	G	A	11138491	3	1	100	1	0	0	0	0	1	0	0	0	14770	1291	45	1	3337	1	SMARCA4	19	11138491	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	207765	11138491	47990492	740	31334										
ZNF491	126069	broad.mit.edu	37	chr19	11917579	11917579	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcacactggagagaggcctCataaatgtaagatatgtggg	13	6	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:11917579C>G	uc002mso.1	+	3	1096	c.811C>G	c.(811-813)CAT>GAT	p.H271D		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	271	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGAGAGGCCTCATAAATGTAA	0.408													0	0	0	1	0	39	54										G	11917579	C	G	11917579	3	3	100	1	0	0	0	0	1	0	0	0	17939	826	29	1	813	1	ZNF491	19	11917579	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	779088	11917579	47211404	741	31335										
ZNF878	729747	broad.mit.edu	37	chr19	12155622	12155622	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccacactgcttacattcataGggtttttttgcagagtggat	9	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:12155622G>A	uc002mta.1	-	5	735	c.735C>T	c.(733-735)CCC>CCT	p.P245P		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TACATTCATAGGGTTTTTTTG	0.388													0	0	0	1	0	114	121										A	12155622	G	A	12155622	2	1	100	1	0	0	0	0	0	0	0	1	18193	987	35	2		2	ZNF878	19	12155622	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	238043	12155622	46973361	742	31336										
ZNF878	729747	broad.mit.edu	37	chr19	12156003	12156003	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgactttctttactttcagaGagtctctcccctataagtct	5	11	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:12156003G>C	uc002mta.1	-	5	354	c.354C>G	c.(352-354)CTC>CTG	p.L118L		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TACTTTCAGAGAGTCTCTCCC	0.353													0	0	0	1	0	10	16										C	12156003	G	C	12156003	2	2	100	1	0	0	0	0	0	0	0	1	18193	929	33	1		1	ZNF878	19	12156003	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	381	12156003	46972980	743	31337										
ZNF878	729747	broad.mit.edu	37	chr19	12157504	12157504	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acttccctgtagagatttttCtgggaaggatccagcaaagc	10	9	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:12157504C>A	uc002mta.1	-	3	216	c.216G>T	c.(214-216)CAG>CAT	p.Q72H		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AGAGATTTTTCTGGGAAGGAT	0.478													1	0	2.02627e-32	1	2.28715e-32	67	88										A	12157504	C	A	12157504	3	1	100	1	0	0	0	0	1	0	0	0	18193	912	32	3	1532	3	ZNF878	19	12157504	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1501	12157504	46971479	744	31338										
CC2D1A	54862	broad.mit.edu	37	chr19	14040949	14040949	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acggaggctgcccggcgcctGggcaacgatggcagcagggt	18	12	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:14040949G>C	uc002mxo.2	+	27	3068	c.2769G>C	c.(2767-2769)CTG>CTC	p.L923L	CC2D1A_uc002mxp.2_Silent_p.L922L|CC2D1A_uc010dzh.2_Silent_p.L492L	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	923					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CCCGGCGCCTGGGCAACGATG	0.692													0	0	0	1	0	10	46										C	14040949	G	C	14040949	2	2	100	1	0	0	0	0	0	0	0	1	2726	1335	47	4		4	CC2D1A	19	14040949	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1883445	14040949	45088034	745	31339										
CYP4F8	11283	broad.mit.edu	37	chr19	15728816	15728816	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgccttgcttgcaggtcacTcccacagaggagggcttgag	13	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:15728816T>G	uc002nbi.2	+	3	268	c.204T>G	c.(202-204)ACT>ACG	p.T68T	CYP4F8_uc010xoi.1_Silent_p.T68T|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	68					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGCAGGTCACTCCCACAGAGG	0.413													0	0	0	1	0	11	47										G	15728816	T	G	15728816	2	3	100	1	0	0	0	0	0	0	0	1	4191	1538	54	5		5	CYP4F8	19	15728816	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	1687867	15728816	43400167	746	31340										
USE1	55850	broad.mit.edu	37	chr19	17327021	17327021	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggccaaccagttcctggcccCtggccgtgtgccaaccacag	11	17	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:17327021C>G	uc002nfo.2	+	4	335	c.275C>G	c.(274-276)CCT>CGT	p.P92R	USE1_uc002nfn.2_Missense_Mutation_p.P92R|USE1_uc010eal.1_Missense_Mutation_p.P92R	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	92	Cytoplasmic (Potential).				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TTCCTGGCCCCTGGCCGTGTG	0.607													0	0	0	1	0	10	45										G	17327021	C	G	17327021	3	3	100	1	0	0	0	0	1	0	0	0	17028	681	24	4	289	4	USE1	19	17327021	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1598205	17327021	41801962	747	31341										
GTPBP3	84705	broad.mit.edu	37	chr19	17452366	17452366	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccagggttgcctggatgccCtcggccactacaagcagtca	11	14	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:17452366C>G	uc010eas.2	+	9	1398	c.1333C>G	c.(1333-1335)CTC>GTC	p.L445V	GTPBP3_uc010xpo.1_Missense_Mutation_p.L467V|GTPBP3_uc002ngh.3_Missense_Mutation_p.L424V|GTPBP3_uc002ngg.3_Missense_Mutation_p.L477V|GTPBP3_uc002ngi.3_Missense_Mutation_p.L111V	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V	445					tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						CCTGGATGCCCTCGGCCACTA	0.657													0	0	0	1	0	20	55										G	17452366	C	G	17452366	3	3	100	1	0	0	0	0	1	0	0	0	6881	681	24	4	1459	4	GTPBP3	19	17452366	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	125345	17452366	41676617	748	31342										
NXNL1	115861	broad.mit.edu	37	chr19	17571379	17571379	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agatcatcctcaaagggcagGaaaagccatttctttggcat	9	9	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:17571379G>T	uc002ngs.2	-	1	347	c.300C>A	c.(298-300)TTC>TTA	p.F100L		NM_138454	NP_612463	Q96CM4	NXNL1_HUMAN	nucleoredoxin-like 1	100	Thioredoxin.				cell redox homeostasis	nuclear outer membrane					0						CAAAGGGCAGGAAAAGCCATT	0.378													1	0	6.38683e-12	1	6.92474e-12	26	28										T	17571379	G	T	17571379	3	4	100	1	0	0	0	0	1	0	0	0	10788	1165	41	3	346	3	NXNL1	19	17571379	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	119013	17571379	41557604	749	31343										
MPV17L2	84769	broad.mit.edu	37	chr19	18304802	18304802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcaagaaggtcctcgtggatCagctggtagcctctccattg	11	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:18304802C>T	uc002nid.2	+	2	368	c.316C>T	c.(316-318)CAG>TAG	p.Q106*	MPV17L2_uc010ebj.2_Nonsense_Mutation_p.Q42*	NM_032683	NP_116072	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	106	Helical; (Potential).					integral to membrane					0						CCTCGTGGATCAGCTGGTAGC	0.592													0	0	0	1	0	13	34										T	18304802	C	T	18304802	4	4	100	1	0	0	0	0	0	1	0	0	9747	827	29	1	322	1	MPV17L2	19	18304802	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	733423	18304802	40824181	750	31344										
SLC25A42	284439	broad.mit.edu	37	chr19	19218757	19218757	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgagagaagaggggctgaaGactctctaccatggatttat	12	7	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:19218757G>A	uc002nlf.1	+	7	703	c.552G>A	c.(550-552)AAG>AAA	p.K184K		NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	184	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			AGGGGCTGAAGACTCTCTACC	0.562													0	0	0	1	0	84	66										A	19218757	G	A	19218757	2	1	100	1	0	0	0	0	0	0	0	1	14507	933	33	1		1	SLC25A42	19	19218757	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	913955	19218757	39910226	751	31345										
ZNF99	7652	broad.mit.edu	37	chr19	22939880	22939880	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaattagcttatgtttcttAagggttgaggaattgttaaa	10	2	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:22939880A>T	uc010xrh.1	-	6	2451	c.2451T>A	c.(2449-2451)CTT>CTA	p.L817L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGTTTCTTAAGGGTTGAGG	0.383													0	0	0	1	0	16	102										T	22939880	A	T	22939880	2	4	100	1	0	0	0	0	0	0	0	1	18201	349	13	5		5	ZNF99	19	22939880	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	3721123	22939880	36189103	752	31346										
C19orf40	91442	broad.mit.edu	37	chr19	33467501	33467501	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttccaagcatccagcaactGagtaatgcttccattgggga	9	10	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:33467501G>C	uc002nud.3	+	5	679	c.561G>C	c.(559-561)CTG>CTC	p.L187L		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	187	RuvA domain 2-like.				DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					TCCAGCAACTGAGTAATGCTT	0.557								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	30	132										C	33467501	G	C	33467501	2	2	100	1	0	0	0	0	0	0	0	1	1923	1277	45	1		1	C19orf40	19	33467501	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	10527621	33467501	25661482	753	31347										
SCN1B	6324	broad.mit.edu	37	chr19	35530030	35530030	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcccctgcagccaacagagAcatggcatccatcgtgtctg	11	14	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:35530030A>T	uc002nxp.2	+	4	649	c.458A>T	c.(457-459)GAC>GTC	p.D153V	SCN1B_uc010xsg.1_Missense_Mutation_p.D82V|HPN_uc002nxq.1_5'Flank|HPN_uc002nxr.1_5'Flank|HPN_uc002nxs.1_5'Flank	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	153	Extracellular (Potential).				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCCAACAGAGACATGGCATCC	0.363													0	0	0	1	0	97	85										T	35530030	A	T	35530030	3	4	100	1	0	0	0	0	1	0	0	0	13915	275	10	5	831	5	SCN1B	19	35530030	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	2062529	35530030	23598953	754	31348										
DMKN	93099	broad.mit.edu	37	chr19	36002341	36002341	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actcactgccgctgtcacctCtgctgccaccactgttgcca	7	18	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36002341C>A	uc002nzm.3	-	5	1073	c.890G>T	c.(889-891)AGA>ATA	p.R297I	DMKN_uc002nzj.2_5'Flank|DMKN_uc002nzk.3_5'Flank|DMKN_uc002nzl.3_5'Flank|DMKN_uc002nzo.3_Intron|DMKN_uc002nzn.3_Intron|DMKN_uc002nzw.2_5'Flank|DMKN_uc002nzr.2_5'Flank|DMKN_uc002nzp.2_5'Flank|DMKN_uc002nzq.2_5'Flank|DMKN_uc002nzt.2_5'Flank|DMKN_uc002nzs.2_5'Flank|DMKN_uc002nzu.2_5'Flank|DMKN_uc002nzv.2_5'Flank|DMKN_uc010xsv.1_5'Flank|DMKN_uc010xsw.1_5'Flank|DMKN_uc002nzx.3_5'Flank|DMKN_uc002nzy.3_5'Flank|DMKN_uc002nzz.2_RNA|DMKN_uc002oac.3_Missense_Mutation_p.R297I|DMKN_uc010eeb.2_Missense_Mutation_p.R297I|DMKN_uc002oaa.3_Missense_Mutation_p.R297I|DMKN_uc002oab.3_Missense_Mutation_p.R297I	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	297	Gly-rich.					extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCTGTCACCTctgctgccacc	0.318													1	0	0.004672	1	0.00472309	3	23										A	36002341	C	A	36002341	3	1	100	1	0	0	0	0	1	0	0	0	4582	913	32	3	905	3	DMKN	19	36002341	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	472311	36002341	23126642	755	31349										
KIRREL2	84063	broad.mit.edu	37	chr19	36357214	36357214	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aacccacacctgggcatggtCcccccctgcagactttacag	8	17	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36357214C>A	uc002ocb.3	+	15	2159	c.1947C>A	c.(1945-1947)GTC>GTA	p.V649V	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.V596V|KIRREL2_uc002ocd.3_Silent_p.V611V|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	649	Pro-rich.|Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGGCATGGTCCCCCCCTGCA	0.627													1	0	1.37285e-15	1	1.51267e-15	17	106										A	36357214	C	A	36357214	2	1	100	1	0	0	0	0	0	0	0	1	8325	842	30	3		3	KIRREL2	19	36357214	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	354873	36357214	22771769	756	31350										
WDR62	284403	broad.mit.edu	37	chr19	36593683	36593683	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acgtggaggcctctgaagctGaagaccacttcttcaaccca	9	13	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36593683G>A	uc002odc.2	+	27	3341	c.3250G>A	c.(3250-3252)GAA>AAA	p.E1084K	WDR62_uc002odd.2_Missense_Mutation_p.E1089K	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	1084					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTCTGAAGCTGAAGACCACTT	0.617													0	0	0	1	0	15	54										A	36593683	G	A	36593683	3	1	100	1	0	0	0	0	1	0	0	0	17310	1291	45	1	3371	1	WDR62	19	36593683	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	236469	36593683	22535300	757	31351										
COX7A1	1346	broad.mit.edu	37	chr19	36642380	36642380	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcaccgcccagacacagcgtCattgtcactcggtacaggat	9	14	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36642380C>T	uc002odm.1	-	3	633	c.171G>A	c.(169-171)ATG>ATA	p.M57I		NM_001864	NP_001855	P24310	CX7A1_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 1	57	Helical; (By similarity).				generation of precursor metabolites and energy	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GACACAGCGTCATTGTCACTC	0.617													0	0	0	1	0	9	77										T	36642380	C	T	36642380	3	4	100	1	0	0	0	0	1	0	0	0	3779	826	29	1	76	1	COX7A1	19	36642380	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	48697	36642380	22486603	758	31352										
MAP4K1	11184	broad.mit.edu	37	chr19	39103253	39103253	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaccccacgcctgcctacctGagagggtgcacatcaaagag	11	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:39103253G>C	uc002oix.1	-	9	771	c.663C>G	c.(661-663)CTC>CTG	p.L221L	MAP4K1_uc002oiy.1_Silent_p.L221L|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	221	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTGCCTACCTGAGAGGGTGCA	0.607													0	0	0	1	0	30	26										C	39103253	G	C	39103253	2	2	100	1	0	0	0	0	0	0	0	1	9259	1277	45	1		1	MAP4K1	19	39103253	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2460873	39103253	20025730	759	31353										
ACTN4	81	broad.mit.edu	37	chr19	39208629	39208629	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggctacgaggagtggctgctGaatgagatccgcaggctgga	17	8	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:39208629G>A	uc002oja.1	+	11	1265	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	ACTN4_uc010egc.1_Silent_p.L402L	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	402	Spectrin 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGTGGCTGCTGAATGAGATCC	0.627													0	0	0	1	0	5	10										A	39208629	G	A	39208629	2	1	100	1	0	0	0	0	0	0	0	1	207	1277	45	1		1	ACTN4	19	39208629	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	105376	39208629	19920354	760	31354										
NFKBIB	4793	broad.mit.edu	37	chr19	39396010	39396010	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccctgcttcagccccgccccCggcgccccagggaagccccc	10	24	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:39396010C>T	uc002ojw.2	+	3	512	c.454C>T	c.(454-456)CGG>TGG	p.R152W	NFKBIB_uc002ojx.2_Missense_Mutation_p.R120W|NFKBIB_uc002ojy.2_Missense_Mutation_p.R152W	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	152	ANK 3.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GCCCCGCCCCCGGCGCCCCAG	0.711													0	0	0	1	0	44	21										T	39396010	C	T	39396010	3	4	100	1	0	0	0	0	1	0	0	0	10378	643	23	2	464	2	NFKBIB	19	39396010	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	187381	39396010	19732973	761	31355										
FCGBP	8857	broad.mit.edu	37	chr19	40368511	40368511	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccagatgaaaggggtccgcaGaagccagggccctcgtactg	14	12	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:40368511G>A	uc002omp.3	-	28	12845	c.12837C>T	c.(12835-12837)TTC>TTT	p.F4279F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4279	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGGTCCGCAGAAGCCAGGGC	0.642													0	0	0	1	0	9	29										A	40368511	G	A	40368511	2	1	100	1	0	0	0	0	0	0	0	1	5778	933	33	1		1	FCGBP	19	40368511	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	972501	40368511	18760472	762	31356										
FCGBP	8857	broad.mit.edu	37	chr19	40433168	40433168	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccatctatggtcagcccgctGatagccttcgtctgtgccac	9	15	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:40433168G>A	uc002omp.3	-	2	1109	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	367	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCAGCCCGCTGATAGCCTTCG	0.612													0	0	0	1	0	20	42										A	40433168	G	A	40433168	2	1	100	1	0	0	0	0	0	0	0	1	5778	1280	45	1		1	FCGBP	19	40433168	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	64657	40433168	18695815	763	31357										
SPTBN4	57731	broad.mit.edu	37	chr19	41066206	41066206	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtgaggatgcccgcctgcatGtcagctccacagccgacgcc	12	16	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:41066206G>A	uc002ony.2	+	27	5898	c.5812G>A	c.(5812-5814)GTC>ATC	p.V1938I	SPTBN4_uc002onx.2_Missense_Mutation_p.V1938I|SPTBN4_uc002onz.2_Missense_Mutation_p.V1938I|SPTBN4_uc010egx.2_Missense_Mutation_p.V681I|SPTBN4_uc002ooa.2_Missense_Mutation_p.V614I	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1938	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCGCCTGCATGTCAGCTCCAC	0.647													0	0	0	1	0	33	120										A	41066206	G	A	41066206	3	1	100	1	0	0	0	0	1	0	0	0	15120	1377	48	2	5914	2	SPTBN4	19	41066206	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	633038	41066206	18062777	764	31358										
CYP2A6	1548	broad.mit.edu	37	chr19	41352802	41352802	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctgcatgcggatgagaaagGagtcaatgaagtcccgtggg	15	8	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:41352802G>C	uc002opl.3	-	5	830	c.809C>G	c.(808-810)TCC>TGC	p.S270C	CYP2A6_uc010ehe.1_Missense_Mutation_p.S66C|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	270					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	GATGAGAAAGGAGTCAATGAA	0.582													0	0	0	1	0	9	76										C	41352802	G	C	41352802	3	2	100	1	0	0	0	0	1	0	0	0	4162	1174	41	1	695	1	CYP2A6	19	41352802	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	286596	41352802	17776181	765	31359										
ZNF574	64763	broad.mit.edu	37	chr19	42585402	42585402	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tacccctggtggaagccattGagatctaccctctggccgag	11	13	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:42585402G>C	uc002osm.3	+	2	2813	c.2644G>C	c.(2644-2646)GAG>CAG	p.E882Q	ZNF574_uc002osk.3_Missense_Mutation_p.E972Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GGAAGCCATTGAGATCTACCC	0.642													0	0	0	1	0	50	48										C	42585402	G	C	42585402	3	2	100	1	0	0	0	0	1	0	0	0	18003	1291	45	1	2646	1	ZNF574	19	42585402	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1232600	42585402	16543581	766	31360										
ZNF526	116115	broad.mit.edu	37	chr19	42728831	42728831	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaggaggcactgaccacacaGaatgttggcctggagccgga	15	10	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:42728831G>A	uc002osz.1	+	3	432	c.276G>A	c.(274-276)CAG>CAA	p.Q92Q		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				TGACCACACAGAATGTTGGCC	0.617													0	0	0	1	0	37	63										A	42728831	G	A	42728831	2	1	100	1	0	0	0	0	0	0	0	1	17964	933	33	1		1	ZNF526	19	42728831	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	143429	42728831	16400152	767	31361										
MEGF8	1954	broad.mit.edu	37	chr19	42837807	42837807	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acttccttttcctggacacaGagtgcacgtatgactacctg	8	12	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:42837807G>A	uc002otl.3	+	2	873	c.238G>A	c.(238-240)GAG>AAG	p.E80K		NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	80	Extracellular (Potential).|CUB 1.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CCTGGACACAGAGTGCACGTA	0.617													0	0	0	1	0	21	90										A	42837807	G	A	42837807	3	1	100	1	0	0	0	0	1	0	0	0	9463	943	33	1	244	1	MEGF8	19	42837807	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	108976	42837807	16291176	768	31362										
ZNF45	7596	broad.mit.edu	37	chr19	44418392	44418392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggtccagcagatttgaggccCggcagaagcctttcccacac	11	14	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:44418392C>T	uc002oxu.1	-	4	1295	c.1196G>A	c.(1195-1197)CGG>CAG	p.R399Q	ZNF45_uc002oxw.1_Missense_Mutation_p.R399Q|ZNF45_uc002oxv.1_Missense_Mutation_p.R399Q	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	399	C2H2-type 9.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ATTTGAGGCCCGGCAGAAGCC	0.502													0	0	0	1	0	53	85										T	44418392	C	T	44418392	3	4	100	1	0	0	0	0	1	0	0	0	17918	652	23	2	856	2	ZNF45	19	44418392	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1580585	44418392	14710591	769	31363										
ZNF223	7766	broad.mit.edu	37	chr19	44570825	44570825	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttcagaaacatcagagaattCacacaggggagaagccattc	9	9	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:44570825C>G	uc002oyf.1	+	5	1097	c.844C>G	c.(844-846)CAC>GAC	p.H282D	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	282	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TCAGAGAATTCACACAGGGGA	0.423													0	0	0	1	0	112	188										G	44570825	C	G	44570825	3	3	100	1	0	0	0	0	1	0	0	0	17774	826	29	1	858	1	ZNF223	19	44570825	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	152433	44570825	14558158	770	31364										
ZNF223	7766	broad.mit.edu	37	chr19	44571219	44571219	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaagagctttagacaggcctCaagtattttgaatcataaga	9	6	2	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:44571219C>G	uc002oyf.1	+	5	1491	c.1238C>G	c.(1237-1239)TCA>TGA	p.S413*	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	413	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				AGACAGGCCTCAAGTATTTTG	0.423													0	0	0	1	0	13	131										G	44571219	C	G	44571219	4	3	100	1	0	0	0	0	0	1	0	0	17774	838	29	1	1252	1	ZNF223	19	44571219	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	394	44571219	14557764	771	31365										
ERCC1	2067	broad.mit.edu	37	chr19	45926592	45926592	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcttccttgctggcggccctGagggctggggcaccccctct	13	16	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:45926592G>A	uc002pbs.1	-	2	187	c.41C>T	c.(40-42)TCA>TTA	p.S14L	ERCC1_uc002pbt.1_Missense_Mutation_p.S14L|ERCC1_uc002pbu.1_Missense_Mutation_p.S14L|ERCC1_uc002pbv.2_Missense_Mutation_p.S14L	NM_001983	NP_001974	P07992	ERCC1_HUMAN	excision repair cross-complementing 1 isofrom 2	14					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			ovary(2)	2		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		TGGCGGCCCTGAGGGCTGGGG	0.622								NER					0	0	0	1	0	5	19										A	45926592	G	A	45926592	3	1	100	1	0	0	0	0	1	0	0	0	5212	1294	45	1	1017	1	ERCC1	19	45926592	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1355373	45926592	13202391	772	31366										
PNMAL2	57469	broad.mit.edu	37	chr19	46998632	46998632	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcttcgacgtctgcctgctCcaggccctccgggatgccgg	14	16	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:46998632C>T	uc002pes.2	-	1	538	c.91G>A	c.(91-93)GAG>AAG	p.E31K	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	31										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		tctgcctgctccaggccctcc	0.03													0	0	0	1	0	18	65										T	46998632	C	T	46998632	3	4	100	1	0	0	0	0	1	0	0	0	12158	864	30	1	1820	1	PNMAL2	19	46998632	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1072040	46998632	12130351	773	31367										
PRKD2	25865	broad.mit.edu	37	chr19	47195050	47195050	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tcgtcagggaagatctggtaGacagtggcaatgtcctacag	13	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:47195050G>A	uc002pfh.2	-	13	1986	c.1644C>T	c.(1642-1644)GTC>GTT	p.V548V	PRKD2_uc002pfd.2_5'Flank|PRKD2_uc010eks.2_5'Flank|PRKD2_uc010ekt.2_5'UTR|PRKD2_uc002pfe.2_Silent_p.V68V|PRKD2_uc002pff.2_Silent_p.V68V|PRKD2_uc002pfg.2_Silent_p.V391V|PRKD2_uc002pfi.2_Silent_p.V548V|PRKD2_uc002pfj.2_Silent_p.V548V|PRKD2_uc010xye.1_Silent_p.V548V|PRKD2_uc002pfk.2_Silent_p.V391V	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	548					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		AGATCTGGTAGACAGTGGCAA	0.577													0	0	0	1	0	27	57										A	47195050	G	A	47195050	2	1	100	1	0	0	0	0	0	0	0	1	12519	929	33	1		1	PRKD2	19	47195050	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	196418	47195050	11933933	774	31368										
LIG1	3978	broad.mit.edu	37	chr19	48640828	48640828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggaacttgctgaagaccccgGaggcagtgagcggaggtggt	18	8	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:48640828G>A	uc002pia.1	-	13	1325	c.1205C>T	c.(1204-1206)TCC>TTC	p.S402F	LIG1_uc010xze.1_Missense_Mutation_p.S95F|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.S334F|LIG1_uc010xzg.1_Missense_Mutation_p.S371F|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	402					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GAAGACCCCGGAGGCAGTGAG	0.677								NER					0	0	0	1	0	33	25										A	48640828	G	A	48640828	3	1	100	1	0	0	0	0	1	0	0	0	8781	1174	41	1	1618	1	LIG1	19	48640828	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1445778	48640828	10488155	775	31369										
LIG1	3978	broad.mit.edu	37	chr19	48643250	48643250	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtggcctgggccactgccttGagaaggacaccatcacccac	11	15	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:48643250G>C	uc002pia.1	-	12	1185	c.1065C>G	c.(1063-1065)CTC>CTG	p.L355L	LIG1_uc010xze.1_Silent_p.L48L|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Silent_p.L287L|LIG1_uc010xzg.1_Silent_p.L324L|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	355					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CCACTGCCTTGAGAAGGACAC	0.622								NER					0	0	0	1	0	29	123										C	48643250	G	C	48643250	2	2	100	1	0	0	0	0	0	0	0	1	8781	1277	45	1		1	LIG1	19	48643250	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	2422	48643250	10485733	776	31370										
LIG1	3978	broad.mit.edu	37	chr19	48660322	48660322	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	actgtccatgggagaggtgtCagagagggaagcattgttct	15	6	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:48660322C>T	uc002pia.1	-	5	439	c.319G>A	c.(319-321)GAC>AAC	p.D107N	LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.D107N|LIG1_uc010xzg.1_Missense_Mutation_p.D77N|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	107					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GGAGAGGTGTCAGAGAGGGAA	0.577								NER					0	0	0	1	0	20	136										T	48660322	C	T	48660322	3	4	100	1	0	0	0	0	1	0	0	0	8781	826	29	1	2536	1	LIG1	19	48660322	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	17072	48660322	10468661	777	31371										
PLEKHA4	57664	broad.mit.edu	37	chr19	49341304	49341304	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgtgccactgcgacgcctCagtagccagggcttgggaga	14	12	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:49341304C>G	uc002pkx.2	-	19	2598	c.2047G>C	c.(2047-2049)GAG>CAG	p.E683Q	HSD17B14_uc002pkv.1_5'Flank|HSD17B14_uc010emk.1_5'Flank|PLEKHA4_uc002pkw.1_Nonstop_Mutation_p.*178S|PLEKHA4_uc010eml.2_Nonstop_Mutation_p.*584S	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	683						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		TGCGACGCCTCAGTAGCCAGG	0.542													0	0	0	1	0	14	94										G	49341304	C	G	49341304	3	3	100	1	0	0	0	0	1	0	0	0	12058	838	29	1	300	1	PLEKHA4	19	49341304	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	680982	49341304	9787679	778	31372										
GYS1	2997	broad.mit.edu	37	chr19	49481247	49481247	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tccagcatcttgttcatgtcGggaaggctcccactgcaagg	11	12	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:49481247G>C	uc002plp.2	-	10	1483	c.1242C>G	c.(1240-1242)CCC>CCG	p.P414P	GYS1_uc010xzy.1_Silent_p.P47P|GYS1_uc010emm.2_Silent_p.P350P|GYS1_uc010xzz.1_Silent_p.P334P|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	414					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGTTCATGTCGGGAAGGCTCC	0.542													0	0	0	1	0	13	99										C	49481247	G	C	49481247	2	2	100	1	0	0	0	0	0	0	0	1	6912	1103	39	4		4	GYS1	19	49481247	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	139943	49481247	9647736	779	31373										
KLK5	25818	broad.mit.edu	37	chr19	51452167	51452167	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	accaagcactttgtcccagcAgagggacaatgagaggagac	12	10	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:51452167A>G	uc002pue.2	-	5	758	c.540T>C	c.(538-540)TCT>TCC	p.S180S	KLK5_uc002puf.2_Silent_p.S180S|KLK5_uc002pug.2_Silent_p.S180S	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	180	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		TTGTCCCAGCAGAGGGACAAT	0.532													0	0	0	1	0	32	67										G	51452167	A	G	51452167	2	3	100	1	0	0	0	0	0	0	0	1	8407	175	7	5		5	KLK5	19	51452167	Silent	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	1970920	51452167	7676816	780	31374										
KLK6	5653	broad.mit.edu	37	chr19	51466738	51466738	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtggatcacagcccggacaaCagaactctgctcctgggaac	11	13	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:51466738C>G	uc002pui.2	-	5	525	c.265G>C	c.(265-267)GTT>CTT	p.V89L	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Missense_Mutation_p.V98L|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_5'UTR|KLK6_uc002pul.2_Missense_Mutation_p.V89L|KLK6_uc002pum.2_5'UTR	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	89	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		GCCCGGACAACAGAACTCTGC	0.572													0	0	0	1	0	13	79										G	51466738	C	G	51466738	3	3	100	1	0	0	0	0	1	0	0	0	8408	478	17	4	481	4	KLK6	19	51466738	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	14571	51466738	7662245	781	31375										
ZNF836	162962	broad.mit.edu	37	chr19	52663800	52663800	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggtccagggatttccactcCtcctgagagaattctatggc	11	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:52663800C>T	uc010ydi.1	-	4	434	c.60G>A	c.(58-60)GAG>GAA	p.E20E	ZNF836_uc010ydj.1_Silent_p.E20E	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTCCACTCCTCCTGAGAGA	0.438													0	0	0	1	0	55	195										T	52663800	C	T	52663800	2	4	100	1	0	0	0	0	0	0	0	1	18184	680	24	2		2	ZNF836	19	52663800	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1197062	52663800	6465183	782	31376										
ZNF816A	125893	broad.mit.edu	37	chr19	53456059	53456059	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acagccctgtataaagccctCtgtgcagggttcaggcattt	10	11	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:53456059C>G	uc002qal.1	-	4	436	c.135G>C	c.(133-135)CAG>CAC	p.Q45H	ZNF321_uc010eqj.2_Missense_Mutation_p.Q29H|ZNF321_uc002qak.1_Missense_Mutation_p.Q29H|ZNF816A_uc002qam.1_Missense_Mutation_p.Q29H	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		ATAAAGCCCTCTGTGCAGGGT	0.458													0	0	0	1	0	85	223										G	53456059	C	G	53456059	3	3	100	1	0	0	0	0	1	0	0	0	18174	912	32	1	1828	1	ZNF816A	19	53456059	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	792259	53456059	5672924	783	31377										
ZNF665	79788	broad.mit.edu	37	chr19	53668107	53668107	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctgaagaccttgccgcaatCattacatttgtatggttttt	7	8	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:53668107C>T	uc010eqm.1	-	4	1736	c.1636G>A	c.(1636-1638)GAT>AAT	p.D546N		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	481	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TTGCCGCAATCATTACATTTG	0.388													0	0	0	1	0	175	81										T	53668107	C	T	53668107	3	4	100	1	0	0	0	0	1	0	0	0	18070	826	29	1	404	1	ZNF665	19	53668107	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	212048	53668107	5460876	784	31378										
ZNF761	388561	broad.mit.edu	37	chr19	53958226	53958226	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cctgaaatgcacatatttcaGaccgaagagaaaattgataa	7	7	1	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:53958226G>C	uc010eqp.2	+	7	923	c.465G>C	c.(463-465)CAG>CAC	p.Q155H	ZNF761_uc010ydy.1_Missense_Mutation_p.Q101H|ZNF761_uc002qbt.1_Missense_Mutation_p.Q101H	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACATATTTCAGACCGAAGAGA	0.388													0	0	0	1	0	79	210										C	53958226	G	C	53958226	3	2	100	1	0	0	0	0	1	0	0	0	18133	933	33	1	476	1	ZNF761	19	53958226	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	290119	53958226	5170757	785	31379										
CACNG7	59284	broad.mit.edu	37	chr19	54444867	54444867	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttcctccttcctactcaaaGaggtgacgtccgtgggacct	9	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:54444867G>C	uc002qcr.1	+	4	583	c.568G>C	c.(568-570)GAG>CAG	p.E190Q	CACNG7_uc010era.1_Missense_Mutation_p.E190Q	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	190	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCTACTCAAAGAGGTGACGTC	0.443													0	0	0	1	0	13	182										C	54444867	G	C	54444867	3	2	100	1	0	0	0	0	1	0	0	0	2562	943	33	1	582	1	CACNG7	19	54444867	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	486641	54444867	4684116	786	31380										
TTYH1	57348	broad.mit.edu	37	chr19	54937898	54937898	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctggagctgctggtctgcctCttcaccctcctgggcctggc	12	16	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:54937898C>G	uc002qfq.2	+	5	779	c.687C>G	c.(685-687)CTC>CTG	p.L229L	TTYH1_uc010yey.1_Silent_p.L278L|TTYH1_uc002qfr.2_Silent_p.L229L|TTYH1_uc002qft.2_Silent_p.L229L|TTYH1_uc002qfu.1_Silent_p.L141L	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	229	Helical; Name=3; (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TGGTCTGCCTCTTCACCCTCC	0.647													0	0	0	1	0	15	102										G	54937898	C	G	54937898	2	3	100	1	0	0	0	0	0	0	0	1	16736	900	32	1		1	TTYH1	19	54937898	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	493031	54937898	4191085	787	31381										
NLRP7	199713	broad.mit.edu	37	chr19	55435133	55435133	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaaaaaagtcacagcacggaGgtgccgttgccccggaagca	12	11	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:55435133G>T	uc002qih.3	-	10	2994	c.2918C>A	c.(2917-2919)CCT>CAT	p.P973H	NLRP7_uc002qig.3_Missense_Mutation_p.P1002H|NLRP7_uc002qii.3_Missense_Mutation_p.P1030H|NLRP7_uc010esk.2_3'UTR|NLRP7_uc010esl.2_Missense_Mutation_p.P1058H	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	973							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ACAGCACGGAGGTGCCGTTGC	0.463													1	0	2.24893e-16	1	2.48066e-16	42	82										T	55435133	G	T	55435133	3	4	100	1	0	0	0	0	1	0	0	0	10482	1000	35	4	28	4	NLRP7	19	55435133	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	497235	55435133	3693850	788	31382										
RDH13	112724	broad.mit.edu	37	chr19	55556446	55556446	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aaatctgctccagaggttatCtggggaggggctgctccctc	13	11	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:55556446C>G	uc002qio.3	-	7	1177	c.992G>C	c.(991-993)AGA>ACA	p.R331T	RDH13_uc002qip.2_Missense_Mutation_p.R260T|RDH13_uc010esr.1_RNA	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	331							binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	CAGAGGTTATCTGGGGAGGGG	0.647													0	0	0	1	0	15	53										G	55556446	C	G	55556446	3	3	100	1	0	0	0	0	1	0	0	0	13192	913	32	1	7	1	RDH13	19	55556446	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	121313	55556446	3572537	789	31383										
ZNF787	126208	broad.mit.edu	37	chr19	56600188	56600188	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	agcaggcgtagggcttctcgCccgtgtggatgcgccggtgc	17	12	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:56600188C>G	uc010eth.1	-	3	472	c.353G>C	c.(352-354)GGC>GCC	p.G118A		NM_001002836	NP_001002836	Q6DD87	ZN787_HUMAN	zinc finger protein 787	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		GGGCTTCTCGCCCGTGTGGAT	0.682													0	0	0	1	0	10	12										G	56600188	C	G	56600188	3	3	100	1	0	0	0	0	1	0	0	0	18156	739	26	4	802	4	ZNF787	19	56600188	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1043742	56600188	2528795	790	31384										
ZNF543	125919	broad.mit.edu	37	chr19	57835137	57835137	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagagaaccttgtatcagGaggtgatgctggagacctgc	13	10	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:57835137G>C	uc002qoi.1	+	2	451	c.106G>C	c.(106-108)GAG>CAG	p.E36Q		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTTGTATCAGGAGGTGATGCT	0.527													0	0	0	1	0	26	66										C	57835137	G	C	57835137	3	2	100	1	0	0	0	0	1	0	0	0	17973	1175	41	1	112	1	ZNF543	19	57835137	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1234949	57835137	1293846	791	31385										
ZNF550	162972	broad.mit.edu	37	chr19	58058594	58058594	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	catgcaatcatagggcttctCtccagtgtggatgatgtaat	10	8	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:58058594C>T	uc002qpe.1	-	2	895	c.895G>A	c.(895-897)GAG>AAG	p.E299K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TAGGGCTTCTCTCCAGTGTGG	0.478													0	0	0	1	0	12	44										T	58058594	C	T	58058594	3	4	100	1	0	0	0	0	1	0	0	0	17979	922	32	1	254	1	ZNF550	19	58058594	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	223457	58058594	1070389	792	31386										
ZNF544	27300	broad.mit.edu	37	chr19	58772414	58772414	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggttcatggtactcacctcaGagagactgtttgctcaaagg	11	9	4	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:58772414G>C	uc010euo.2	+	7	916	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E120Q|ZNF544_uc010yhy.1_Missense_Mutation_p.E120Q|ZNF544_uc002qrt.3_Missense_Mutation_p.E6Q|ZNF544_uc002qru.3_Missense_Mutation_p.E6Q|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		ACTCACCTCAGAGAGACTGTT	0.458													0	0	0	1	0	28	39										C	58772414	G	C	58772414	3	2	100	1	0	0	0	0	1	0	0	0	17974	943	33	1	456	1	ZNF544	19	58772414	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	713820	58772414	356569	793	31387										
ZNF544	27300	broad.mit.edu	37	chr19	58772614	58772614	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcagatgggaagcactgtgaGagtcatcagtgtgctagagc	15	7	2	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:58772614G>C	uc010euo.2	+	7	1116	c.642G>C	c.(640-642)GAG>GAC	p.E214D	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E186D|ZNF544_uc010yhy.1_Missense_Mutation_p.E186D|ZNF544_uc002qrt.3_Missense_Mutation_p.E72D|ZNF544_uc002qru.3_Missense_Mutation_p.E72D|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AGCACTGTGAGAGTCATCAGT	0.378													0	0	0	1	0	22	51										C	58772614	G	C	58772614	3	2	100	1	0	0	0	0	1	0	0	0	17974	933	33	1	656	1	ZNF544	19	58772614	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	200	58772614	356369	794	31388										
C20orf186	149954	broad.mit.edu	37	chr20	31685467	31685467	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcccacttatcatcaggatCcaggtgctgaacccaccatc	7	15	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:31685467C>A	uc010zue.1	+	11	1458	c.1443C>A	c.(1441-1443)ATC>ATA	p.I481I		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	481						cytoplasm|extracellular region	lipid binding				0						TCATCAGGATCCAGGTGCTGA	0.597													1	0	1.39806e-14	1	1.53379e-14	29	256										A	31685467	C	A	31685467	2	1	100	1	0	0	0	0	0	0	0	1	2098	845	30	3		3	C20orf186	20	31685467	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		31685467	31340053	795	31389										
C20orf144	128864	broad.mit.edu	37	chr20	32251484	32251484	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaaggtagcgagcgcgagccGaggatgccggtactgctgct	17	10	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:32251484G>T	uc002wzs.1	+	2	305	c.273G>T	c.(271-273)CCG>CCT	p.P91P	NECAB3_uc002wzl.2_5'Flank|NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron|C20orf134_uc002wzt.2_5'Flank	NM_080825	NP_543015	Q9BQM9	CT144_HUMAN	hypothetical protein LOC128864	91											0						AGCGCGAGCCGAGGATGCCGG	0.741													1	0	0.000157383	1	0.000160863	8	4										T	32251484	G	T	32251484	2	4	100	1	0	0	0	0	0	0	0	1	2090	1045	37	3		3	C20orf144	20	32251484	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	566017	32251484	30774036	796	31390										
C20orf144	128864	broad.mit.edu	37	chr20	32251518	32251518	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgctgctgctgcggcggcaaGaggcgcggcggccggaagag	20	11	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:32251518G>C	uc002wzs.1	+	2	339	c.307G>C	c.(307-309)GAG>CAG	p.E103Q	NECAB3_uc002wzl.2_5'Flank|NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron|C20orf134_uc002wzt.2_5'Flank	NM_080825	NP_543015	Q9BQM9	CT144_HUMAN	hypothetical protein LOC128864	103											0						GCGGCGGCAAGAGGCGCGGCG	0.766													0	0	0	1	0	2	3										C	32251518	G	C	32251518	3	2	100	1	0	0	0	0	1	0	0	0	2090	943	33	1	313	1	C20orf144	20	32251518	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	34	32251518	30774002	797	31391										
RALY	22913	broad.mit.edu	37	chr20	32661429	32661429	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggggctaaagagagcagcatCtgccatatacaggtggggct	15	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:32661429C>G	uc002xab.2	+	4	615	c.317C>G	c.(316-318)TCT>TGT	p.S106C	RALY_uc010zui.1_Missense_Mutation_p.S106C|RALY_uc002xac.2_Missense_Mutation_p.S106C|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.S106C	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	106						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						AGAGCAGCATCTGCCATATAC	0.517													0	0	0	1	0	13	66										G	32661429	C	G	32661429	3	3	100	1	0	0	0	0	1	0	0	0	13019	913	32	1	323	1	RALY	20	32661429	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	409911	32661429	30364091	798	31392										
MYH7B	57644	broad.mit.edu	37	chr20	33588881	33588881	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgctggagcagacggtgcgcGagctccaggcccgccttgag	16	14	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:33588881G>A	uc002xbi.1	+	39	5613	c.5521G>A	c.(5521-5523)GAG>AAG	p.E1841K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1799	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GACGGTGCGCGAGCTCCAGGC	0.637													0	0	0	1	0	10	53										A	33588881	G	A	33588881	3	1	100	1	0	0	0	0	1	0	0	0	10040	1059	37	1	5675	1	MYH7B	20	33588881	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	927452	33588881	29436639	799	31393										
CEP250	11190	broad.mit.edu	37	chr20	34086527	34086527	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagcttcatcaagacctgtgGaagactcaacagacccgggt	10	11	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:34086527G>T	uc002xcm.2	+	28	4430	c.3759G>T	c.(3757-3759)TGG>TGT	p.W1253C	CEP250_uc010zve.1_Missense_Mutation_p.W621C	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1253	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AAGACCTGTGGAAGACTCAAC	0.532													1	0	2.22156e-40	1	2.51595e-40	82	22										T	34086527	G	T	34086527	3	4	100	1	0	0	0	0	1	0	0	0	3252	1183	41	3	3853	3	CEP250	20	34086527	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	497646	34086527	28938993	800	31394										
C20orf4	25980	broad.mit.edu	37	chr20	34828499	34828499	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tggacctgagctatgccctgGagactgtgctcaacaagcag	12	11	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:34828499G>C	uc002xfc.1	+	2	802	c.709G>C	c.(709-711)GAG>CAG	p.E237Q	C20orf4_uc002xfd.1_Missense_Mutation_p.E237Q|C20orf4_uc002xfe.1_Missense_Mutation_p.E237Q	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	237											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				CTATGCCCTGGAGACTGTGCT	0.577													0	0	0	1	0	12	46										C	34828499	G	C	34828499	3	2	100	1	0	0	0	0	1	0	0	0	2111	1175	41	1	711	1	C20orf4	20	34828499	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	741972	34828499	28197021	801	31395										
TGIF2	60436	broad.mit.edu	37	chr20	35207317	35207317	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ccgctacaacgcctacccctCagagcaggagaagctgagcc	10	16	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:35207317C>A	uc002xfn.2	+	2	313	c.140C>A	c.(139-141)TCA>TAA	p.S47*	C20orf24_uc002xfo.2_Nonsense_Mutation_p.S47*	NM_021809	NP_068581	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	47	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)|skin(1)	2	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GCCTACCCCTCAGAGCAGGAG	0.517													1	0	0.000151284	1	0.000155097	12	83										A	35207317	C	A	35207317	4	1	100	1	0	0	0	0	0	1	0	0	15823	838	29	3	142	3	TGIF2	20	35207317	Nonsense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	378818	35207317	27818203	802	31396										
CTNNBL1	56259	broad.mit.edu	37	chr20	36431427	36431427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggaagatcaagaaagtggGaaccactgagaaggaacatg	13	6	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:36431427G>A	uc010zvw.1	+	12	1281	c.1190G>A	c.(1189-1191)GGA>GAA	p.G397E	CTNNBL1_uc002xhh.2_Missense_Mutation_p.G210E|CTNNBL1_uc002xhi.2_RNA|CTNNBL1_uc002xhj.2_Missense_Mutation_p.G145E	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	397					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				AAGAAAGTGGGAACCACTGAG	0.428													0	0	0	1	0	10	26										A	36431427	G	A	36431427	3	1	100	1	0	0	0	0	1	0	0	0	4018	1174	41	1	1232	1	CTNNBL1	20	36431427	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1224110	36431427	26594093	803	31397										
RALGAPB	57148	broad.mit.edu	37	chr20	37191299	37191299	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgggcatgtttctaccagttGgtctattaattgttgtgatg	11	5	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:37191299G>T	uc002xiw.2	+	24	3913	c.3656G>T	c.(3655-3657)TGG>TTG	p.W1219L	RALGAPB_uc002xix.2_Missense_Mutation_p.W1215L|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.W997L	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1219	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TCTACCAGTTGGTCTATTAAT	0.403													1	0	2.59497e-14	1	2.84078e-14	42	43										T	37191299	G	T	37191299	3	4	100	1	0	0	0	0	1	0	0	0	13015	1357	47	4	3746	4	RALGAPB	20	37191299	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	759872	37191299	25834221	804	31398										
SLC32A1	140679	broad.mit.edu	37	chr20	37353648	37353648	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aggcagcggagctcctctgcCgccctccggctccaaggacc	12	18	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:37353648C>T	uc002xjc.2	+	1	544	c.281C>T	c.(280-282)CCG>CTG	p.P94L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	94	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCTCCTCTGCCGCCCTCCGGC	0.662													0	0	0	1	0	13	45										T	37353648	C	T	37353648	3	4	100	1	0	0	0	0	1	0	0	0	14565	652	23	2	283	2	SLC32A1	20	37353648	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	162349	37353648	25671872	805	31399										
GTSF1L	149699	broad.mit.edu	37	chr20	42355269	42355269	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacgatgccaggtggtactgGaatctgctgagtgggattcg	15	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:42355269G>A	uc002xld.2	-	1	374	c.66C>T	c.(64-66)TTC>TTT	p.F22F	GTSF1L_uc002xlc.2_Silent_p.F22F	NM_176791	NP_789761	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like isoform 1	22	CHHC-type.						metal ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GGTGGTACTGGAATCTGCTGA	0.493													0	0	0	1	0	36	87										A	42355269	G	A	42355269	2	1	100	1	0	0	0	0	0	0	0	1	6887	1165	41	1		1	GTSF1L	20	42355269	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5001621	42355269	20670251	806	31400										
KCNS1	3787	broad.mit.edu	37	chr20	43723710	43723710	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tctggcgccggtagaagtggGagaacttgttgaagatgatg	16	5	1	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:43723710G>A	uc002xnc.2	-	5	1779	c.1382C>T	c.(1381-1383)TCC>TTC	p.S461F	KCNS1_uc002xnd.2_Missense_Mutation_p.S461F	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	461	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				GTAGAAGTGGGAGAACTTGTT	0.597													0	0	0	1	0	10	131										A	43723710	G	A	43723710	3	1	100	1	0	0	0	0	1	0	0	0	8088	1174	41	1	202	1	KCNS1	20	43723710	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1368441	43723710	19301810	807	31401										
MATN4	8785	broad.mit.edu	37	chr20	43933045	43933045	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gcgcgcctgtgccgccacctCggccacgcggtcctggggcc	15	19	0	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:43933045C>T	uc002xnn.2	-	3	653	c.466G>A	c.(466-468)GAG>AAG	p.E156K	MATN4_uc002xno.2_Missense_Mutation_p.E156K|MATN4_uc002xnp.2_Missense_Mutation_p.E156K|MATN4_uc010zwr.1_Missense_Mutation_p.E104K|MATN4_uc002xnr.1_Missense_Mutation_p.E156K|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	156	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				GCCGCCACCTCGGCCACGCGG	0.746													0	0	0	1	0	4	20										T	43933045	C	T	43933045	3	4	100	1	0	0	0	0	1	0	0	0	9336	893	31	1	1311	1	MATN4	20	43933045	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	209335	43933045	19092475	808	31402										
CEBPB	1051	broad.mit.edu	37	chr20	48807986	48807986	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gaagccggccgagtacggctAcgtgagcctggggcgcctgg	18	12	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:48807986A>G	uc002xvi.1	+	1	611	c.416A>G	c.(415-417)TAC>TGC	p.Y139C	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	139					acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			GAGTACGGCTACGTGAGCCTG	0.577													0	0	0	1	0	2	0										G	48807986	A	G	48807986	3	3	100	1	0	0	0	0	1	0	0	0	3200	391	14	5	418	5	CEBPB	20	48807986	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	4874941	48807986	14217534	809	31403										
CDH4	1002	broad.mit.edu	37	chr20	60485588	60485606	+	Frame_Shift_Del	DEL	CAGTGGGGATCCATCCGGG	CAGTGGGGATCCATCCGGG	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aatgccgtttaccgcatcatCagtggggatccatccgggca					rs35293044		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:60485588_60485606delCAGTGGGGATCCATCCGGG	uc002ybn.1	+	9	1313_1331	c.1299_1317delCAGTGGGGATCCATCCGGG	c.(1297-1317)ATCAGTGGGGATCCATCCGGGfs	p.I433fs	CDH4_uc002ybp.1_Frame_Shift_Del_p.I359fs	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	433_439	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACCGCATCATCAGTGGGGATCCATCCGGGCACTTCAGCG	0.603																		7	73	---	---								-	60485606	CAGTGGGGATCCATCCGGG	-	60485588	7	5	100	1	0	1	0	1	0	0	0	0	3112	816	29	0	1333	0	CDH4	20	60485588	Frame_Shift_Del	DEL	CAGTGGGGATCCATCCGGG	TCGA-G2-A3VY-01A-11D-A22Z-08	11677602	60485588	2539932	810	31404										
LSM14B	149986	broad.mit.edu	37	chr20	60708371	60708371	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcggacgacgtgggccgaaGagaggaagctcaacacagag	17	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:60708371G>C	uc010gjy.1	+	8	1218	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q	LSM14B_uc002ybv.2_Missense_Mutation_p.E312Q|LSM14B_uc010zzz.1_Missense_Mutation_p.E258Q	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	338	TFG box.				multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GTGGGCCGAAGAGAGGAAGCT	0.612													0	0	0	1	0	34	44										C	60708371	G	C	60708371	3	2	100	1	0	0	0	0	1	0	0	0	9055	943	33	1	1042	1	LSM14B	20	60708371	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	222783	60708371	2317149	811	31405										
ZBTB46	140685	broad.mit.edu	37	chr20	62421402	62421402	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagctcgctccctccgtactGagacggtgaaacctgctctt	9	15	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:62421402G>A	uc002ygv.1	-	2	910	c.709C>T	c.(709-711)CAG>TAG	p.Q237*	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CCTCCGTACTGAGACGGTGAA	0.597													0	0	0	1	0	4	50										A	62421402	G	A	62421402	4	1	100	1	0	0	0	0	0	1	0	0	17544	1299	45	1	1076	1	ZBTB46	20	62421402	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1713031	62421402	604118	812	31406										
PRPF6	24148	broad.mit.edu	37	chr20	62654184	62654184	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggtgttccccagcaagaaGagtgtgtggctgcgcgccgc	15	12	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:62654184G>C	uc002yho.2	+	13	1890	c.1722G>C	c.(1720-1722)AAG>AAC	p.K574N	PRPF6_uc002yhp.2_Missense_Mutation_p.K574N	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	574	HAT 4.				assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					CCAGCAAGAAGAGTGTGTGGC	0.582													0	0	0	1	0	19	58										C	62654184	G	C	62654184	3	2	100	1	0	0	0	0	1	0	0	0	12574	933	33	1	1772	1	PRPF6	20	62654184	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	232782	62654184	371336	813	31407										
TPTE	7179	broad.mit.edu	37	chr21	10942732	10942732	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtaacgtaagtgaggtctaGgtcaaatccatcccttgtgt	10	8	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:10942732G>C	uc002yip.1	-	13	1077	c.709C>G	c.(709-711)CTA>GTA	p.L237V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.L219V|TPTE_uc002yir.1_Missense_Mutation_p.L199V|TPTE_uc010gkv.1_Missense_Mutation_p.L99V	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	237	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGAGGTCTAGGTCAAATCCA	0.323													0	0	0	1	0	41	289										C	10942732	G	C	10942732	3	2	100	1	0	0	0	0	1	0	0	0	16427	991	35	4	994	4	TPTE	21	10942732	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		10942732	37187163	814	31408										
RNF160	26046	broad.mit.edu	37	chr21	30307437	30307437	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	aagacaatactaaccgtcatGccattaaatagttgtgtact	6	8	1	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:30307437G>T	uc002ymr.2	-	27	5020	c.5007C>A	c.(5005-5007)GGC>GGA	p.G1669G		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1623							ligase activity|zinc ion binding				0						TAACCGTCATGCCATTAAATA	0.313													1	0	4.36969e-10	1	4.67295e-10	13	47										T	30307437	G	T	30307437	2	4	100	1	0	0	0	0	0	0	0	1	13455	1306	46	4		4	RNF160	21	30307437	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	19364705	30307437	17822458	815	31409										
USP16	10600	broad.mit.edu	37	chr21	30419060	30419060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttgtactattgaccatcctGaagacagtgaatatgaagct	8	7	0	5			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:30419060G>C	uc002ymy.2	+	14	1631	c.1429G>C	c.(1429-1431)GAA>CAA	p.E477Q	USP16_uc002ymx.2_Missense_Mutation_p.E476Q|USP16_uc002ymw.2_Missense_Mutation_p.E477Q|USP16_uc011acm.1_Missense_Mutation_p.E462Q|USP16_uc011acn.1_Missense_Mutation_p.E143Q|USP16_uc011aco.1_Missense_Mutation_p.E167Q	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	477					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4						TGACCATCCTGAAGACAGTGA	0.318													0	0	0	1	0	9	51										C	30419060	G	C	30419060	3	2	100	1	0	0	0	0	1	0	0	0	17044	1291	45	1	1479	1	USP16	21	30419060	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	111623	30419060	17710835	816	31410										
C21orf63	59271	broad.mit.edu	37	chr21	33876247	33876247	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atgaaacaggtataaacttcGacccaagcggatcgaaggtt	10	8	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:33876247G>C	uc002ypr.1	+	7	1281	c.871G>C	c.(871-873)GAC>CAC	p.D291H	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.D288H|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.D196H|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	291	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						TATAAACTTCGACCCAAGCGG	0.443													0	0	0	1	0	37	112										C	33876247	G	C	33876247	3	2	100	1	0	0	0	0	1	0	0	0	2131	1058	37	1	897	1	C21orf63	21	33876247	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3457187	33876247	14253648	817	31411										
ITSN1	6453	broad.mit.edu	37	chr21	35147080	35147080	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cgacaacttgagtgggaacgGaatcgaaggcaagaactact	12	8	0	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:35147080G>T	uc002yta.1	+	13	1621	c.1353G>T	c.(1351-1353)CGG>CGT	p.R451R	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Silent_p.R451R|ITSN1_uc010gmg.2_Silent_p.R414R|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Silent_p.R451R|ITSN1_uc010gmi.2_Silent_p.R414R|ITSN1_uc010gmj.2_Silent_p.R335R|ITSN1_uc002ysy.2_Silent_p.R451R|ITSN1_uc002ysx.2_Silent_p.R414R|ITSN1_uc002ytb.1_Silent_p.R451R|ITSN1_uc002ytc.1_Silent_p.R451R|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Silent_p.R414R|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Silent_p.R451R|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Silent_p.R385R	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	451	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGTGGGAACGGAATCGAAGGC	0.368													1	0	1.5739e-10	1	1.68845e-10	17	43										T	35147080	G	T	35147080	2	4	100	1	0	0	0	0	0	0	0	1	7926	1161	41	3		3	ITSN1	21	35147080	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1270833	35147080	12982815	818	31412										
RIPK4	54101	broad.mit.edu	37	chr21	43187192	43187192	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcccatggggtcccgccgtCgccctccatcgcgcacgtct	12	19	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:43187192C>G	uc002yzn.1	-	1	58	c.10G>C	c.(10-12)GAC>CAC	p.D4H		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	4						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GTCCCGCCGTCGCCCTCCATC	0.736													0	0	0	1	0	3	6										G	43187192	C	G	43187192	3	3	100	1	0	0	0	0	1	0	0	0	13383	884	31	1	2376	1	RIPK4	21	43187192	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	8040112	43187192	4942703	819	31413										
UBASH3A	53347	broad.mit.edu	37	chr21	43833142	43833142	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgtccccttagtgtgaagacCagaaggtggaatgcctgtac	12	9	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:43833142C>G	uc002zbe.2	+	4	400	c.364C>G	c.(364-366)CAG>GAG	p.Q122E	UBASH3A_uc002zbf.2_Missense_Mutation_p.Q122E|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.Q122E	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	122						cytosol|nucleus				ovary(3)	3						GTGTGAAGACCAGAAGGTGGA	0.512													0	0	0	1	0	33	141										G	43833142	C	G	43833142	3	3	100	1	0	0	0	0	1	0	0	0	16836	595	21	4	378	4	UBASH3A	21	43833142	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	645950	43833142	4296753	820	31414										
RRP1	8568	broad.mit.edu	37	chr21	45222172	45222172	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	caggcattttccctgaagatGagatcccagagaaggcctgc	11	11	0	4			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:45222172G>C	uc002zds.2	+	12	1120	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q	RRP1_uc011aez.1_Missense_Mutation_p.E343Q|RRP1_uc010gpk.1_Missense_Mutation_p.E193Q|RRP1_uc010gpl.1_Missense_Mutation_p.E241Q|RRP1_uc010gpm.1_Missense_Mutation_p.E210Q	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	343					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CCCTGAAGATGAGATCCCAGA	0.602													0	0	0	1	0	23	27										C	45222172	G	C	45222172	3	2	100	1	0	0	0	0	1	0	0	0	13685	1291	45	1	1073	1	RRP1	21	45222172	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	1389030	45222172	2907723	821	31415										
TRAPPC10	7109	broad.mit.edu	37	chr21	45475622	45475622	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaaggactcttctcgaactCaggaatcctggaatgccttc	9	11	3	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:45475622C>G	uc002zea.2	+	5	695	c.526C>G	c.(526-528)CAG>GAG	p.Q176E	TRAPPC10_uc010gpo.2_5'UTR|TRAPPC10_uc002zdz.2_Missense_Mutation_p.Q176E	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	176					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTCTCGAACTCAGGAATCCTG	0.478													0	0	0	1	0	91	101										G	45475622	C	G	45475622	3	3	100	1	0	0	0	0	1	0	0	0	16454	827	29	1	544	1	TRAPPC10	21	45475622	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	253450	45475622	2654273	822	31416										
GAB4	128954	broad.mit.edu	37	chr22	17468986	17468986	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttgttcttgggggaggtgctGatgggagcagctgggctcag	19	6	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:17468986G>A	uc002zlw.2	-	3	658	c.550C>T	c.(550-552)CAG>TAG	p.Q184*	GAB4_uc010gqs.1_Nonsense_Mutation_p.Q167*	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	184										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GGGAGGTGCTGATGGGAGCAG	0.612													0	0	0	1	0	21	19										A	17468986	G	A	17468986	4	1	100	1	0	0	0	0	0	1	0	0	6151	1299	45	1	1206	1	GAB4	22	17468986	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08		17468986	33835580	823	31417										
PRODH	5625	broad.mit.edu	37	chr22	18918658	18918658	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcccatagaaggtcatcttCatgagcttgttgaatagcct	9	9	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:18918658C>A	uc010grl.2	-	2	341	c.327G>T	c.(325-327)ATG>ATT	p.M109I	PRODH_uc002zoj.3_5'UTR|PRODH_uc002zol.3_5'UTR|PRODH_uc002zok.3_Missense_Mutation_p.M109I	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	109					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	AGGTCATCTTCATGAGCTTGT	0.557													1	0	5.3912e-06	1	5.58905e-06	17	37										A	18918658	C	A	18918658	3	1	100	1	0	0	0	0	1	0	0	0	12548	826	29	3	1527	3	PRODH	22	18918658	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	1449672	18918658	32385908	824	31418										
CCDC157	550631	broad.mit.edu	37	chr22	30766456	30766456	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccagacctgccaagagccaGagagcatccctgtcagagcc	10	16	1	4	rs5753102		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:30766456G>C	uc011aku.1	+	5	1222	c.562G>C	c.(562-564)GAG>CAG	p.E188Q	CCDC157_uc011akv.1_Missense_Mutation_p.E188Q	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	188										central_nervous_system(1)	1						CCAAGAGCCAGAGAGCATCCC	0.602													0	0	0	1	0	35	33										C	30766456	G	C	30766456	3	2	100	1	0	0	0	0	1	0	0	0	2789	943	33	1	572	1	CCDC157	22	30766456	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	11847798	30766456	20538110	825	31419										
INPP5J	27124	broad.mit.edu	37	chr22	31522449	31522449	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctgggcggtggtgacgacagCgacggcgcagacatgatcgc	17	11	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:31522449C>A	uc003aju.3	+	3	1451	c.1359C>A	c.(1357-1359)AGC>AGA	p.S453R	INPP5J_uc010gwf.2_Missense_Mutation_p.S453R|INPP5J_uc003ajv.3_Missense_Mutation_p.S86R|INPP5J_uc003ajs.3_Missense_Mutation_p.S86R|INPP5J_uc011alk.1_Missense_Mutation_p.S386R|INPP5J_uc010gwg.2_Missense_Mutation_p.S18R|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.S85R|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	453	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						GTGACGACAGCGACGGCGCAG	0.672													1	0	1.7881e-09	1	1.90818e-09	30	60										A	31522449	C	A	31522449	3	1	100	1	0	0	0	0	1	0	0	0	7759	767	27	4	265	4	INPP5J	22	31522449	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	755993	31522449	19782117	826	31420										
PISD	23761	broad.mit.edu	37	chr22	32016599	32016599	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cccacagctgtcagtgagaaGaagccatgtttccagtcccc	9	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:32016599G>T	uc003alm.3	-	7	952	c.945C>A	c.(943-945)TTC>TTA	p.F315L	PISD_uc003alk.2_Missense_Mutation_p.F281L|PISD_uc003all.2_Intron|PISD_uc011alr.1_Missense_Mutation_p.F280L|PISD_uc003aln.3_Intron	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	315					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	TCAGTGAGAAGAAGCCATGTT	0.587													1	0	3.03607e-14	1	3.32009e-14	13	24										T	32016599	G	T	32016599	3	4	100	1	0	0	0	0	1	0	0	0	11946	933	33	3	292	3	PISD	22	32016599	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	494150	32016599	19287967	827	31421										
RFPL2	10739	broad.mit.edu	37	chr22	32590428	32590434	+	Frame_Shift_Del	DEL	TCCCACC	TCCCACC	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gggccttttattggtgagatTcccacctcccactgggtcac							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:32590428_32590434delTCCCACC	uc003amg.3	-	3	1099_1105	c.163_169delGGTGGGA	c.(163-171)GGTGGGAATfs	p.G55fs	RFPL2_uc003ame.3_5'Flank|RFPL2_uc003amf.3_Intron|RFPL2_uc003amh.3_Intron	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	55_57							zinc ion binding			skin(1)	1						TTGGTGAGATTCCCACCTCCCACTGGG	0.507																		2	4	---	---								-	32590434	TCCCACC	-	32590428	7	5	100	1	0	1	0	1	0	0	0	0	13254	1783	62	0	1061	0	RFPL2	22	32590428	Frame_Shift_Del	DEL	TCCCACC	TCGA-G2-A3VY-01A-11D-A22Z-08	573829	32590428	18714138	828	31422										
EFCAB6	64800	broad.mit.edu	37	chr22	43985982	43985982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cagatgggtcagctccccttCggtaagagaacatccacatt	9	12	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:43985982C>T	uc003bdy.1	-	24	3219	c.3004G>A	c.(3004-3006)GAA>AAA	p.E1002K	EFCAB6_uc003bdz.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzi.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzj.1_Missense_Mutation_p.E228K	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1002					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGCTCCCCTTCGGTAAGAGAA	0.408													0	0	0	1	0	31	43										T	43985982	C	T	43985982	3	4	100	1	0	0	0	0	1	0	0	0	4939	893	31	1	1537	1	EFCAB6	22	43985982	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	11395554	43985982	7318584	829	31423										
MXRA5	25878	broad.mit.edu	37	chrX	3229461	3229461	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gtggccacacagtccactttCaggtcacccccgtagaagac	9	15	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:3229461C>T	uc004crg.3	-	7	6940	c.6783G>A	c.(6781-6783)CTG>CTA	p.L2261L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2261	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGTCCACTTTCAGGTCACCCC	0.557													0	0	0	1	0	35	35										T	3229461	C	T	3229461	2	4	100	1	0	0	0	0	0	0	0	1	10003	813	29	1		1	MXRA5	23	3229461	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08		3229461	152041099	830	31424										
ARHGAP6	395	broad.mit.edu	37	chrX	11197423	11197423	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	atatggctgtattacgcacaGagagtgttgatgaaagctgt	12	5	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:11197423G>A	uc004cup.1	-	7	2352	c.1479C>T	c.(1477-1479)CTC>CTT	p.L493L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Silent_p.L493L|ARHGAP6_uc004cum.1_Silent_p.L290L|ARHGAP6_uc004cun.1_Silent_p.L313L|ARHGAP6_uc010neb.1_Silent_p.L315L|ARHGAP6_uc011mif.1_Silent_p.L290L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	493	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						ATTACGCACAGAGAGTGTTGA	0.453													0	0	0	1	0	54	4										A	11197423	G	A	11197423	2	1	100	1	0	0	0	0	0	0	0	1	887	956	33	1		1	ARHGAP6	23	11197423	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7967962	11197423	144073137	831	31425										
KLHL34	257240	broad.mit.edu	37	chrX	21674920	21674922	+	In_Frame_Del	DEL	CTC	CTC	-													0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acgttctgggtgagctcccaCtcctcctcctcctcctcttc							TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:21674920_21674922delCTC	uc004czz.1	-	1	1527_1529	c.985_987delGAG	c.(985-987)GAGdel	p.E329del		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	329	Kelch 1.|Glu-rich.									ovary(1)	1						TGAGCTCCCActcctcctcctcc	0.527																		2	4	---	---								-	21674922	CTC	-	21674920	7	5	100	1	0	1	0	1	0	0	0	0	8387	564	20	0	951	0	KLHL34	23	21674920	In_Frame_Del	DEL	CTC	TCGA-G2-A3VY-01A-11D-A22Z-08	10477497	21674920	133595640	832	31426										
DDX3X	1654	broad.mit.edu	37	chrX	41203072	41203072	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ggcgaggctttgagggccatGaaggtagatgtttctttata	14	5	1	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:41203072G>A	uc004dfe.2	+	8	1617	c.762G>A	c.(760-762)ATG>ATA	p.M254I	DDX3X_uc010nhf.1_Missense_Mutation_p.M238I|DDX3X_uc004dff.2_Missense_Mutation_p.M254I|DDX3X_uc011mkq.1_Missense_Mutation_p.M238I|DDX3X_uc011mkr.1_Missense_Mutation_p.M254I|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_Intron	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	254	Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TGAGGGCCATGAAGGTAGATG	0.398										HNSCC(61;0.18)			0	0	0	1	0	20	20										A	41203072	G	A	41203072	3	1	100	1	0	0	0	0	1	0	0	0	4358	1290	45	1	792	1	DDX3X	23	41203072	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	19528152	41203072	114067488	833	31427										
WDR45	11152	broad.mit.edu	37	chrX	48932868	48932868	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gctgactcagcaggcacagtGaagctcgccaggctccactg	12	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:48932868G>A	uc004dmk.1	-	10	1072	c.900C>T	c.(898-900)TTC>TTT	p.F300F	PRAF2_uc004dmh.2_5'Flank|PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Intron|WDR45_uc004dmj.1_Silent_p.F261F|WDR45_uc004dml.1_Silent_p.F301F|WDR45_uc004dmm.1_Silent_p.F265F|WDR45_uc010nim.1_Intron|WDR45_uc004dmn.1_Silent_p.F191F|WDR45_uc004dmo.1_Silent_p.F323F|WDR45_uc004dmp.1_Silent_p.F301F	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	300				FTV -> YTA (in Ref. 1; AAV80764).	autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						CAGGCACAGTGAAGCTCGCCA	0.597													0	0	0	1	0	6	12										A	48932868	G	A	48932868	2	1	100	1	0	0	0	0	0	0	0	1	17294	1281	45	1		1	WDR45	23	48932868	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	7729796	48932868	106337692	834	31428										
CCDC22	28952	broad.mit.edu	37	chrX	49106025	49106025	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	taagtatctagctgctctgcAcgaggtgaggggagacatgt	14	7	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:49106025A>T	uc004dnd.1	+	15	1847	c.1691A>T	c.(1690-1692)CAC>CTC	p.H564L	CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	564										central_nervous_system(1)	1						GCTGCTCTGCACGAGGTGAGG	0.597													0	0	0	1	0	10	11										T	49106025	A	T	49106025	3	4	100	1	0	0	0	0	1	0	0	0	2797	159	6	5	1749	5	CCDC22	23	49106025	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	173157	49106025	106164535	835	31429										
CCNB3	85417	broad.mit.edu	37	chrX	50053381	50053381	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgaaggaggagctttctgctGaggcagccacaaacatacag	12	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:50053381G>A	uc004dox.3	+	6	2510	c.2212G>A	c.(2212-2214)GAG>AAG	p.E738K	CCNB3_uc004doy.2_Missense_Mutation_p.E738K|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	738					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GCTTTCTGCTGAGGCAGCCAC	0.428													0	0	0	1	0	29	1										A	50053381	G	A	50053381	3	1	100	1	0	0	0	0	1	0	0	0	2914	1291	45	1	2226	1	CCNB3	23	50053381	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	947356	50053381	105217179	836	31430										
SHROOM4	57477	broad.mit.edu	37	chrX	50377284	50377284	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gagctgggccttcctcctctGaatttcattacgcagattgg	10	11	2	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:50377284G>A	uc004dpe.2	-	4	1815	c.1789C>T	c.(1789-1791)CAG>TAG	p.Q597*	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Nonsense_Mutation_p.Q481*	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	597					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TTCCTCCTCTGAATTTCATTA	0.582													0	0	0	1	0	27	1										A	50377284	G	A	50377284	4	1	100	1	0	0	0	0	0	1	0	0	14296	1299	45	1	2716	1	SHROOM4	23	50377284	Nonsense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	323903	50377284	104893276	837	31431										
SHROOM4	57477	broad.mit.edu	37	chrX	50377642	50377642	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	gacctgtcatccacttgtctGgtctttctttctttgctgga	8	11	5	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:50377642G>A	uc004dpe.2	-	4	1457	c.1431C>T	c.(1429-1431)ACC>ACT	p.T477T	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Silent_p.T361T	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	477					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CCACTTGTCTGGTCTTTCTTT	0.527													0	0	0	1	0	73	7										A	50377642	G	A	50377642	2	1	100	1	0	0	0	0	0	0	0	1	14296	1335	47	2		2	SHROOM4	23	50377642	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	358	50377642	104892918	838	31432										
HUWE1	10075	broad.mit.edu	37	chrX	53575134	53575134	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tgcaaatgccactgctggagGactgtgaggagcatgggcta	15	8	0	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:53575134G>A	uc004dsp.2	-	68	10538	c.10136C>T	c.(10135-10137)TCC>TTC	p.S3379F	HUWE1_uc004dsn.2_Missense_Mutation_p.S2187F	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3379					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ACTGCTGGAGGACTGTGAGGA	0.507													0	0	0	1	0	5	3										A	53575134	G	A	53575134	3	1	100	1	0	0	0	0	1	0	0	0	7461	1174	41	1	3056	1	HUWE1	23	53575134	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	3197492	53575134	101695426	839	31433										
MAGEE1	57692	broad.mit.edu	37	chrX	75649791	75649791	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ttaccctgaagccccaagacCctatggaacagaacgtagct	8	13	0	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:75649791C>A	uc004ecm.1	+	1	1675	c.1468C>A	c.(1468-1470)CCT>ACT	p.P490T		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	490						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						GCCCCAAGACCCTATGGAACA	0.483													1	0	2.17888e-05	1	2.24966e-05	9	26										A	75649791	C	A	75649791	3	1	100	1	0	0	0	0	1	0	0	0	9185	623	22	4	1470	4	MAGEE1	23	75649791	Missense_Mutation	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	22074657	75649791	79620769	840	31434										
RPS6KA6	27330	broad.mit.edu	37	chrX	83375020	83375020	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttcttgatctactgactccTtgctgagtccaaaatctata	5	10	3	3			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:83375020T>C	uc004eej.1	-	9	739	c.662A>G	c.(661-663)AAG>AGG	p.K221R	RPS6KA6_uc011mqt.1_Missense_Mutation_p.K221R|RPS6KA6_uc011mqu.1_Missense_Mutation_p.K118R|RPS6KA6_uc010nmo.1_RNA	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	221	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TACTGACTCCTTGCTGAGTCC	0.343													0	0	0	1	0	50	10										C	83375020	T	C	83375020	3	2	100	1	0	0	0	0	1	0	0	0	13655	1609	56	5	1631	5	RPS6KA6	23	83375020	Missense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	7725229	83375020	71895540	841	31435										
MID2	11043	broad.mit.edu	37	chrX	107084381	107084381	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acctgtgaggtctcctactgTgaccgttgcctgcgggccac	12	14	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:107084381T>A	uc004enl.2	+	2	1059	c.486T>A	c.(484-486)TGT>TGA	p.C162*	MID2_uc004enk.2_Nonsense_Mutation_p.C162*	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	162	B box-type 1; degenerate.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TCTCCTACTGTGACCGTTGCC	0.572													0	0	0	1	0	7	23										A	107084381	T	A	107084381	4	1	100	1	0	0	0	0	0	1	0	0	9578	1702	59	5	492	5	MID2	23	107084381	Nonsense_Mutation	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	23709361	107084381	48186179	842	31436										
AMOT	154796	broad.mit.edu	37	chrX	112033888	112033888	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	acattctcctccaaatatttCtgctcccactttgtcatatc	2	14	3	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:112033888C>T	uc004epr.2	-	7	2049	c.2049G>A	c.(2047-2049)CAG>CAA	p.Q683Q	AMOT_uc004eps.2_Silent_p.Q274Q	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	683	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						CCAAATATTTCTGCTCCCACT	0.493													0	0	0	1	0	34	103										T	112033888	C	T	112033888	2	4	100	1	0	0	0	0	0	0	0	1	582	912	32	1		1	AMOT	23	112033888	Silent	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	4949507	112033888	43236672	843	31437										
ODZ1	10178	broad.mit.edu	37	chrX	123518337	123518337	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cttgttatattggcatctacTcctacccttatgtcacatat	4	11	2	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:123518337T>A	uc004euj.2	-	29	6487	c.6423A>T	c.(6421-6423)GGA>GGT	p.G2141G	ODZ1_uc011muj.1_Silent_p.G2147G|ODZ1_uc010nqy.2_Silent_p.G2148G	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2141	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGGCATCTACTCCTACCCTTA	0.398													0	0	0	1	0	38	153										A	123518337	T	A	123518337	2	1	100	1	0	0	0	0	0	0	0	1	10834	1538	54	5		5	ODZ1	23	123518337	Silent	SNP	T	TCGA-G2-A3VY-01A-11D-A22Z-08	11484449	123518337	31752223	844	31438										
ODZ1	10178	broad.mit.edu	37	chrX	123680941	123680941	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	cacacagtcggttaaaccatCtggaaataaaacccaaaacc	5	12	1	0			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:123680941C>G	uc004euj.2	-	15	2499	c.2435_splice	c.e15-1	p.D812_splice	ODZ1_uc011muj.1_Splice_Site_p.D811_splice|ODZ1_uc010nqy.2_Splice_Site_p.D812_splice	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3						immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTTAAACCATCTGGAAATAAA	0.348													0	0	0	1	0	37	3										G	123680941	C	G	123680941	5	3	100	1	0	0	0	0	0	0	1	0	10834	927	32	1	5836	1	ODZ1	23	123680941	Splice_Site	SNP	C	TCGA-G2-A3VY-01A-11D-A22Z-08	162604	123680941	31589619	845	31439										
BCORL1	63035	broad.mit.edu	37	chrX	129149535	129149535	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	ctcttgaccctcagccctcaGactgggaccctggcactgtc	9	17	3	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:129149535G>A	uc004evb.1	+	4	2901	c.2787G>A	c.(2785-2787)CAG>CAA	p.Q929Q	BCORL1_uc010nrd.1_Silent_p.Q831Q	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	929					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TCAGCCCTCAGACTGGGACCC	0.537													0	0	0	1	0	13	34										A	129149535	G	A	129149535	2	1	100	1	0	0	0	0	0	0	0	1	1387	933	33	1		1	BCORL1	23	129149535	Silent	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	5468594	129149535	26121025	846	31440										
GPR119	139760	broad.mit.edu	37	chrX	129519381	129519381	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tagcaatgatgagggaggccAggacagcaaggatcactcca	13	9	1	2			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:129519381A>C	uc011muv.1	-	1	41	c.41T>G	c.(40-42)CTG>CGG	p.L14R		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	14	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GAGGGAGGCCAGGACAGCAAG	0.483													0	0	0	1	0	68	136										C	129519381	A	C	129519381	3	2	100	1	0	0	0	0	1	0	0	0	6634	188	7	5	970	5	GPR119	23	129519381	Missense_Mutation	SNP	A	TCGA-G2-A3VY-01A-11D-A22Z-08	369846	129519381	25751179	847	31441										
DKC1	1736	broad.mit.edu	37	chrX	153995277	153995277	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507692307692308	429	1.4021336437285e-164	4.05458396369138	4.52572314049587	3.51788172992056	1.28938356319661e-07	1.39683219346299e-06	323	tttgtcatttttcaggcaaaGagtatgtggggattgtccgg	13	5	2	1			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:153995277G>C	uc004fmm.2	+	6	664	c.454G>C	c.(454-456)GAG>CAG	p.E152Q	DKC1_uc010nvf.2_Missense_Mutation_p.E152Q|SNORA36A_uc004fmn.2_5'Flank	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	152					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTCAGGCAAAGAGTATGTGGG	0.463									Congenital_Dyskeratosis				0	0	0	1	0	10	49										C	153995277	G	C	153995277	3	2	100	1	0	0	0	0	1	0	0	0	4542	943	33	1	476	1	DKC1	23	153995277	Missense_Mutation	SNP	G	TCGA-G2-A3VY-01A-11D-A22Z-08	24475896	153995277	1275283	848	31442										
AGRN	375790	broad.mit.edu	37	chr1	984698	984698	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggcaccgcctggagctgtccCggcactggcgccggggcacc	16	17	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:984698C>T	uc001ack.1	+	25	4431	c.4381C>T	c.(4381-4383)CGG>TGG	p.R1461W		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1461	Laminin G-like 1.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGAGCTGTCCCGGCACTGGCG	0.687													0	0	0	1	0	15	24										T	984698	C	T	984698	3	4	101	1	0	0	0	0	1	0	0	0	397	643	23	2	4479	2	AGRN	1	984698	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		984698	248265923	1	31443										
MXRA8	54587	broad.mit.edu	37	chr1	1290868	1290868	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agttgccgtcgtcgaaggccGaggccgagagctccaggcgg	17	12	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:1290868G>C	uc001aew.2	-	3	369	c.338C>G	c.(337-339)TCG>TGG	p.S113W	MXRA8_uc001aex.3_Missense_Mutation_p.S113W|MXRA8_uc001aey.3_Missense_Mutation_p.S113W|MXRA8_uc010nyl.1_Missense_Mutation_p.S113W|MXRA8_uc001aez.2_Intron|MXRA8_uc001afa.2_Missense_Mutation_p.S104W	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	113	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GTCGAAGGCCGAGGCCGAGAG	0.468													0	0	0	1	0	9	5										C	1290868	G	C	1290868	3	2	101	1	0	0	0	0	1	0	0	0	10005	1059	37	1	1022	1	MXRA8	1	1290868	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	306170	1290868	247959753	2	31444										
MEGF6	1953	broad.mit.edu	37	chr1	3417236	3417236	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cacgtagccagcctcacacaGacacaggccgctgatggcat	10	15	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:3417236G>A	uc001akl.2	-	21	2895	c.2668C>T	c.(2668-2670)CTG>TTG	p.L890L	MEGF6_uc001akk.2_Silent_p.L785L	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	890	EGF-like 15.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCTCACACAGACACAGGCCG	0.602													0	0	0	1	0	4	7										A	3417236	G	A	3417236	2	1	101	1	0	0	0	0	0	0	0	1	9462	933	33	1		1	MEGF6	1	3417236	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	2126368	3417236	245833385	3	31445										
KCNAB2	8514	broad.mit.edu	37	chr1	6158568	6158568	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cttccgaaactgtcatcttcCattatccacgagattgatag	6	11	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:6158568C>T	uc009vlv.1	+	16	1173	c.1038C>T	c.(1036-1038)TCC>TCT	p.S346S	KCNAB2_uc001alv.1_Silent_p.S346S|KCNAB2_uc001alw.1_Silent_p.S332S|KCNAB2_uc001alx.1_Silent_p.S346S|KCNAB2_uc001aly.1_Silent_p.S394S|KCNAB2_uc009vlw.1_Silent_p.S279S|KCNAB2_uc001alu.2_3'UTR	NM_003636	NP_003627	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related	346						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCATCTTCCATTATCCACG	0.537													0	0	0	1	0	17	30										T	6158568	C	T	6158568	2	4	101	1	0	0	0	0	0	0	0	1	8010	581	21	2		2	KCNAB2	1	6158568	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	2741332	6158568	243092053	4	31446										
LRRC41	10489	broad.mit.edu	37	chr1	46746887	46746887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctggcttgggtggtcaacacGaatagagaggacccgtagca	14	9	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:46746887G>A	uc001cpn.2	-	5	1710	c.1666C>T	c.(1666-1668)CGT>TGT	p.R556C	LRRC41_uc010omb.1_Missense_Mutation_p.R556C	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	556										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					TGGTCAACACGAATAGAGAGG	0.597													0	0	0	1	0	34	66										A	46746887	G	A	46746887	3	1	101	1	0	0	0	0	1	0	0	0	8999	1058	37	1	796	1	LRRC41	1	46746887	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	40588319	46746887	202503734	5	31447										
LRRC7	57554	broad.mit.edu	37	chr1	70504295	70504295	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctagtcctttttctccaggcGtaccatgggagtatcatgat	9	10	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:70504295G>A	uc001dep.2	+	19	2704	c.2674G>A	c.(2674-2676)GTA>ATA	p.V892I	LRRC7_uc009wbg.2_Missense_Mutation_p.V176I|LRRC7_uc001deq.2_Missense_Mutation_p.V133I	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	892						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTCTCCAGGCGTACCATGGGA	0.423													0	0	0	1	0	48	82										A	70504295	G	A	70504295	3	1	101	1	0	0	0	0	1	0	0	0	9020	1145	40	2	2748	2	LRRC7	1	70504295	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	23757408	70504295	178746326	6	31448										
TTLL7	79739	broad.mit.edu	37	chr1	84399296	84399296	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	taaagaatgccttacctccaGaagccatggctttagttttc	7	10	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:84399296G>A	uc001djc.2	-	9	1438	c.1042C>T	c.(1042-1044)CTG>TTG	p.L348L	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	348	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		CTTACCTCCAGAAGCCATGGC	0.373													0	0	0	1	0	67	71										A	84399296	G	A	84399296	2	1	101	1	0	0	0	0	0	0	0	1	16729	933	33	1		1	TTLL7	1	84399296	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	13895001	84399296	164851325	7	31449										
LRRC8B	23507	broad.mit.edu	37	chr1	90058386	90058386	+	Frame_Shift_Del	DEL	G	G	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aagctgcagtgtttacttttGgggaaaaatagcttgatgaa							TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:90058386delG	uc001dni.2	+	8	2703	c.2196delG	c.(2194-2196)TTGfs	p.L732fs	LRRC8B_uc001dnh.2_Frame_Shift_Del_p.L732fs|LRRC8B_uc001dnj.2_Frame_Shift_Del_p.L732fs	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	732	LRR 12.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GTTTACTTTTGGGGAAAAATA	0.423																		47	69	---	---								-	90058386	G	-	90058386	7	5	101	1	0	1	0	1	0	0	0	0	9022	1339	47	0	2202	0	LRRC8B	1	90058386	Frame_Shift_Del	DEL	G	TCGA-GC-A3BM-01A-11D-A22Z-08	5659090	90058386	159192235	8	31450										
DBT	1629	broad.mit.edu	37	chr1	100701061	100701061	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgaactgaacaacctgtccaCggagagcttcaaagacaaat	8	10	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:100701061C>T	uc001dta.2	-	3	215	c.182G>A	c.(181-183)CGT>CAT	p.R61H	DBT_uc010oug.1_Translation_Start_Site	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	61					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		AACCTGTCCACGGAGAGCTTC	0.333													0	0	0	1	0	8	72										T	100701061	C	T	100701061	3	4	101	1	0	0	0	0	1	0	0	0	4258	536	19	2	1302	2	DBT	1	100701061	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	10642675	100701061	148549560	9	31451										
SCNM1	79005	broad.mit.edu	37	chr1	151141526	151141526	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aaaatgttgagtttgactctGatgaggaggaaccacctgat	11	6	1	5			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:151141526G>A	uc001ewz.2	+	7	770	c.658G>A	c.(658-660)GAT>AAT	p.D220N	SCNM1_uc009wmn.2_RNA	NM_024041	NP_076946	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	220					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTTTGACTCTGATGAGGAGGA	0.423													0	0	0	1	0	52	68										A	151141526	G	A	151141526	3	1	101	1	0	0	0	0	1	0	0	0	13926	1290	45	1	684	1	SCNM1	1	151141526	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	50440465	151141526	98109095	10	31452										
HRNR	388697	broad.mit.edu	37	chr1	152188366	152188366	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gatgaacctgagctagatccGtgttgttcacccctagatga	10	10	1	5			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:152188366G>A	uc001ezt.1	-	3	5815	c.5739C>T	c.(5737-5739)CAC>CAT	p.H1913H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1913	21.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTAGATCCGTGTTGTTCAC	0.557													0	0	0	1	0	65	875										A	152188366	G	A	152188366	2	1	101	1	0	0	0	0	0	0	0	1	7359	1136	40	2		2	HRNR	1	152188366	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	1046840	152188366	97062255	11	31453										
FCRL2	79368	broad.mit.edu	37	chr1	157739894	157739894	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggctcactggacccccttcGatgggctggaaggagctggc	15	12	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:157739894G>A	uc001fre.2	-	4	416	c.357C>T	c.(355-357)ATC>ATT	p.I119I	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Silent_p.I119I|FCRL2_uc009wsp.2_Intron|FCRL2_uc010pia.1_Silent_p.I119I	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	119	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GACCCCCTTCGATGGGCTGGA	0.527													0	0	0	1	0	40	41										A	157739894	G	A	157739894	2	1	101	1	0	0	0	0	0	0	0	1	5795	1048	37	1		1	FCRL2	1	157739894	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	5551528	157739894	91510727	12	31454										
SPTA1	6708	broad.mit.edu	37	chr1	158585162	158585162	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ccacaatcttggttagttgaCgcttcatcgcctggatctcc	8	13	3	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:158585162C>T	uc001fst.1	-	48	6831	c.6632G>A	c.(6631-6633)CGT>CAT	p.R2211H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2211	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGTTAGTTGACGCTTCATCGC	0.483													0	0	0	1	0	104	85										T	158585162	C	T	158585162	3	4	101	1	0	0	0	0	1	0	0	0	15115	536	19	2	647	2	SPTA1	1	158585162	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	845268	158585162	90665459	13	31455										
LY9	4063	broad.mit.edu	37	chr1	160769712	160769712	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cccaaagaaaatgtaaccatTatggtcaaaagctacctggg	8	9	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:160769712T>A	uc001fwu.2	+	2	344	c.294T>A	c.(292-294)ATT>ATA	p.I98I	LY9_uc001fwt.2_Silent_p.I98I|LY9_uc010pjs.1_Silent_p.I98I|LY9_uc001fwv.2_Silent_p.I98I|LY9_uc001fww.2_Silent_p.I98I|LY9_uc001fwx.2_Silent_p.I98I|LY9_uc001fwy.1_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	98	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATGTAACCATTATGGTCAAAA	0.468													0	0	0	1	0	70	90										A	160769712	T	A	160769712	2	1	101	1	0	0	0	0	0	0	0	1	9101	1742	61	5		5	LY9	1	160769712	Silent	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08	2184550	160769712	88480909	14	31456										
ATF6	22926	broad.mit.edu	37	chr1	161789557	161789557	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctctcagaaaacgagcaactGaagaaagaaaatggaacact	8	8	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:161789557G>A	uc001gbr.2	+	8	1111	c.1044G>A	c.(1042-1044)CTG>CTA	p.L348L	ATF6_uc001gbq.1_Silent_p.L348L	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	348	Cytoplasmic (Potential).|Leucine-zipper.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			ACGAGCAACTGAAGAAAGAAA	0.448													0	0	0	1	0	19	27										A	161789557	G	A	161789557	2	1	101	1	0	0	0	0	0	0	0	1	1084	1277	45	1		1	ATF6	1	161789557	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	1019845	161789557	87461064	15	31457										
RASAL2	9462	broad.mit.edu	37	chr1	178063703	178063703	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgttcccggcgctggagtccGactcgccgctgcccccggag	14	17	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:178063703G>A	uc001glq.2	+	1	840	c.76G>A	c.(76-78)GAC>AAC	p.D26N	RASAL2_uc009wxb.2_Missense_Mutation_p.D26N|LOC100302401_uc001gln.1_5'Flank|LOC100302401_uc001glo.1_5'Flank|RASAL2_uc009wxa.2_RNA	NM_170692	NP_733793	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 2	Error:Variant_position_missing_in_Q9UJF2_after_alignment					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						GCTGGAGTCCGACTCGCCGCT	0.706													0	0	0	1	0	11	6										A	178063703	G	A	178063703	3	1	101	1	0	0	0	0	1	0	0	0	13064	1058	37	1	78	1	RASAL2	1	178063703	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	16274146	178063703	71186918	16	31458										
TMCC2	9911	broad.mit.edu	37	chr1	205210828	205210828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agatgcatcgcgtctcctacGccatgtccctgcacgacctg	9	16	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:205210828G>A	uc001hbz.1	+	3	847	c.403G>A	c.(403-405)GCC>ACC	p.A135T	TMCC2_uc010prf.1_Missense_Mutation_p.A57T	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	135						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CGTCTCCTACGCCATGTCCCT	0.662													0	0	0	1	0	19	35										A	205210828	G	A	205210828	3	1	101	1	0	0	0	0	1	0	0	0	15990	1087	38	2	409	2	TMCC2	1	205210828	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	27147125	205210828	44039793	17	31459										
TP53BP2	7159	broad.mit.edu	37	chr1	223984287	223984287	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agcagcaattacaggcttacCatatactaattggaaaagga	8	7	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:223984287C>T	uc010pvb.1	-	13	2246	c.1954G>A	c.(1954-1956)GGT>AGT	p.G652S	TP53BP2_uc001hod.2_Missense_Mutation_p.G523S|TP53BP2_uc010puz.1_5'UTR|TP53BP2_uc010pva.1_Missense_Mutation_p.G291S	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	646					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		ACAGGCTTACCATATACTAAT	0.398													0	0	0	1	0	34	77										T	223984287	C	T	223984287	3	4	101	1	0	0	0	0	1	0	0	0	16381	594	21	2	1474	2	TP53BP2	1	223984287	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	18773459	223984287	25266334	18	31460										
OBSCN	84033	broad.mit.edu	37	chr1	228399647	228399647	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agccggtggcggccggcgcgCgcttccgtctggcccaggac	17	16	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:228399647C>T	uc009xez.1	+	2	207	c.163C>T	c.(163-165)CGC>TGC	p.R55C	OBSCN_uc001hsn.2_Missense_Mutation_p.R55C|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	55	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGCCGGCGCGCGCTTCCGTCT	0.687													0	0	0	1	0	11	6										T	228399647	C	T	228399647	3	4	101	1	0	0	0	0	1	0	0	0	10812	768	27	2	165	2	OBSCN	1	228399647	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	4415360	228399647	20850974	19	31461										
RYR2	6262	broad.mit.edu	37	chr1	237756779	237756779	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttctgctatcttcacagtacTattactcagtgagaatcttt	5	9	5	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:237756779T>A	uc001hyl.1	+	33	4399	c.4279T>A	c.(4279-4281)TAT>AAT	p.Y1427N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1427	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCACAGTACTATTACTCAGT	0.388													0	0	0	1	0	12	46										A	237756779	T	A	237756779	3	1	101	1	0	0	0	0	1	0	0	0	13769	1522	53	5	4409	5	RYR2	1	237756779	Missense_Mutation	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08	9357132	237756779	11493842	20	31462										
PPPDE1	51029	broad.mit.edu	37	chr1	244868861	244868861	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctctttctcttctgtagattCtttgtgggaaagagattcct	8	8	4	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:244868861C>G	uc001iao.2	+	5	619	c.355C>G	c.(355-357)CTT>GTT	p.L119V	PPPDE1_uc001iap.2_Missense_Mutation_p.L86V|PPPDE1_uc001iaq.1_RNA	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	119	PPPDE peptidase.									breast(3)	3						TCTGTAGATTCTTTGTGGGAA	0.522													0	0	0	1	0	55	69										G	244868861	C	G	244868861	3	3	101	1	0	0	0	0	1	0	0	0	12408	913	32	1	373	1	PPPDE1	1	244868861	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	7112082	244868861	4381760	21	31463										
OR2T8	343172	broad.mit.edu	37	chr1	248084484	248084484	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgggaccaccggctccacacGcccatgtacttcctcctgag	9	17	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:248084484G>A	uc010pzc.1	+	1	165	c.165G>A	c.(163-165)ACG>ACA	p.T55T		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTCCACACGCCCATGTACT	0.522													0	0	0	1	0	62	95										A	248084484	G	A	248084484	2	1	101	1	0	0	0	0	0	0	0	1	11030	1074	38	2		2	OR2T8	1	248084484	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	3215623	248084484	1166137	22	31464										
LPIN1	23175	broad.mit.edu	37	chr2	11911614	11911614	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agaggcctggaccccagcacGccagcccaagtgatcgctcc	11	17	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:11911614G>A	uc010yjn.1	+	5	679	c.405G>A	c.(403-405)ACG>ACA	p.T135T	LPIN1_uc010yjm.1_Silent_p.T184T|LPIN1_uc002rbt.2_Silent_p.T135T|LPIN1_uc002rbs.2_Silent_p.T135T	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	135					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		ACCCCAGCACGCCAGCCCAAG	0.567													0	0	0	1	0	12	61										A	11911614	G	A	11911614	2	1	101	1	0	0	0	0	0	0	0	1	8918	1074	38	2		2	LPIN1	2	11911614	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		11911614	231287759	23	31465										
GFPT1	2673	broad.mit.edu	37	chr2	69575328	69575328	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	atgatctgctggagttccatCtggagtgtttgcacagctcg	12	9	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:69575328C>T	uc002sfh.2	-	10	1109	c.930G>A	c.(928-930)CAG>CAA	p.Q310Q		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	328					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						GGAGTTCCATCTGGAGTGTTT	0.428													0	0	0	1	0	75	73										T	69575328	C	T	69575328	2	4	101	1	0	0	0	0	0	0	0	1	6345	912	32	1		1	GFPT1	2	69575328	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	57663714	69575328	173624045	24	31466										
ANKRD36	375248	broad.mit.edu	37	chr2	97779652	97779652	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gctcacgtattatgacgccaAtaagagagacaggaaggaaa	11	7	1	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:97779652A>G	uc010yva.1	+	1	420	c.176A>G	c.(175-177)AAT>AGT	p.N59S	ANKRD36_uc002sxn.2_Missense_Mutation_p.N59S|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.N59S|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	59	ANK 1.										0						TATGACGCCAATAAGAGAGAC	0.527													0	0	0	1	0	30	27										G	97779652	A	G	97779652	3	3	101	1	0	0	0	0	1	0	0	0	665	101	4	5	178	5	ANKRD36	2	97779652	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	28204324	97779652	145419721	25	31467										
MYO7B	4648	broad.mit.edu	37	chr2	128380819	128380819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tccccatccaagtcatcttgGccactggagagagcctaacc	8	15	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:128380819G>A	uc002top.2	+	28	3663	c.3610G>A	c.(3610-3612)GCC>ACC	p.A1204T	MYO7B_uc002toq.1_Missense_Mutation_p.A57T|MYO7B_uc002tor.1_Missense_Mutation_p.A57T	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1204	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGTCATCTTGGCCACTGGAGA	0.577													0	0	0	1	0	12	43										A	128380819	G	A	128380819	3	1	101	1	0	0	0	0	1	0	0	0	10083	1203	42	2	3716	2	MYO7B	2	128380819	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	30601167	128380819	114818554	26	31468										
XIRP2	129446	broad.mit.edu	37	chr2	168104956	168104956	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctcttcctccacctccagtaGatgagaaatctgaaagagaa	7	11	2	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:168104956G>A	uc002udx.2	+	8	7072	c.7054G>A	c.(7054-7056)GAT>AAT	p.D2352N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D2177N|XIRP2_uc010fpq.2_Missense_Mutation_p.D2130N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2177	Pro-rich.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACCTCCAGTAGATGAGAAATC	0.473													0	0	0	1	0	47	131										A	168104956	G	A	168104956	3	1	101	1	0	0	0	0	1	0	0	0	17427	942	33	1	7084	1	XIRP2	2	168104956	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	39724137	168104956	75094417	27	31469										
TTN	7273	broad.mit.edu	37	chr2	179579099	179579099	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgtattttccagcattggctGgttccactcttgaaaactgt	8	9	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:179579099G>A	uc010zfg.1	-	88	22894	c.22670C>T	c.(22669-22671)CCA>CTA	p.P7557L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P4218L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCATTGGCTGGTTCCACTCT	0.403													0	0	0	1	0	65	32										A	179579099	G	A	179579099	3	1	101	1	0	0	0	0	1	0	0	0	16732	1348	47	2	78215	2	TTN	2	179579099	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	11474143	179579099	63620274	28	31470										
FAM171B	165215	broad.mit.edu	37	chr2	187626350	187626350	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gctgaggacaagtcgcagttAttcaatgccaaaaactcctc	8	11	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:187626350A>T	uc002ups.2	+	8	1393	c.1281A>T	c.(1279-1281)TTA>TTT	p.L427F	FAM171B_uc002upr.1_Intron|FAM171B_uc002upt.2_5'Flank	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	427	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AGTCGCAGTTATTCAATGCCA	0.383													0	0	0	1	0	52	46										T	187626350	A	T	187626350	3	4	101	1	0	0	0	0	1	0	0	0	5491	446	16	5	1311	5	FAM171B	2	187626350	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	8047251	187626350	55573023	29	31471										
SF3B1	23451	broad.mit.edu	37	chr2	198281605	198281605	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttttagttctccagctttagCtttttctgctagctgttgcc	7	10	2	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:198281605C>T	uc002uue.2	-	6	574	c.526G>A	c.(526-528)GCT>ACT	p.A176T	SF3B1_uc010fsk.1_RNA	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	176					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CCAGCTTTAGCTTTTTCTGCT	0.423													0	0	0	1	0	54	125										T	198281605	C	T	198281605	3	4	101	1	0	0	0	0	1	0	0	0	14149	797	28	2	3468	2	SF3B1	2	198281605	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	10655255	198281605	44917768	30	31472										
ANKRD28	23243	broad.mit.edu	37	chr3	15752761	15752761	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acaagtcctgccaaaatcatCtggggtatctatatcaaatc	6	10	4	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:15752761C>T	uc003caj.1	-	12	1347	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N	ANKRD28_uc003cai.1_Missense_Mutation_p.D248N|ANKRD28_uc011avz.1_Missense_Mutation_p.D248N|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.D432N|ANKRD28_uc003cam.2_Missense_Mutation_p.D435N	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	402						nucleoplasm	protein binding			breast(1)	1						CCAAAATCATCTGGGGTATCT	0.328													0	0	0	1	0	51	6										T	15752761	C	T	15752761	3	4	101	1	0	0	0	0	1	0	0	0	656	913	32	1	2025	1	ANKRD28	3	15752761	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		15752761	182269669	31	31473										
MST1R	4486	broad.mit.edu	37	chr3	49927946	49927946	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acttggtggtaaatctatagGtctgcaggctctccagcgcc	11	11	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49927946G>A	uc003cxy.3	-	18	4046	c.3782C>T	c.(3781-3783)ACC>ATC	p.T1261I	MST1R_uc011bdc.1_Missense_Mutation_p.T140I	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1261	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		AAATCTATAGGTCTGCAGGCT	0.572													0	0	0	1	0	36	2										A	49927946	G	A	49927946	3	1	101	1	0	0	0	0	1	0	0	0	9891	1261	44	2	432	2	MST1R	3	49927946	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	34175185	49927946	148094484	32	31474			1	139		4	4	1310	G		4.307853e-08
MST1R	4486	broad.mit.edu	37	chr3	49928679	49928679	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cacaaacttctgctctgccaGgtactccatgctgcgggcta	9	14	2	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49928679G>A	uc003cxy.3	-	17	3859	c.3595C>T	c.(3595-3597)CTG>TTG	p.L1199L	MST1R_uc011bdc.1_Silent_p.L78L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1199	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGCTCTGCCAGGTACTCCATG	0.612													0	0	0	1	0	63	2										A	49928679	G	A	49928679	2	1	101	1	0	0	0	0	0	0	0	1	9891	991	35	2		2	MST1R	3	49928679	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	733	49928679	148093751	33	31475			1	139		4	4	1310	G		4.307853e-08
MST1R	4486	broad.mit.edu	37	chr3	49928719	49928719	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acctgcaggccaaagctgatGaggtccttcacggtggggtt	14	10	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49928719G>A	uc003cxy.3	-	17	3819	c.3555C>T	c.(3553-3555)CTC>CTT	p.L1185L	MST1R_uc011bdc.1_Silent_p.L64L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1185	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAAAGCTGATGAGGTCCTTCA	0.632													0	0	0	1	0	64	4										A	49928719	G	A	49928719	2	1	101	1	0	0	0	0	0	0	0	1	9891	1277	45	1		1	MST1R	3	49928719	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	40	49928719	148093711	34	31476			1	139		4	4	1310	G		4.307853e-08
MST1R	4486	broad.mit.edu	37	chr3	49929255	49929255	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tctatgtattctccgtggtaGacaactccaaagtggcctgg	10	10	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49929255G>A	uc003cxy.3	-	15	3552	c.3288C>T	c.(3286-3288)GTC>GTT	p.V1096V	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1096	Cytoplasmic (Potential).|ATP.|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CTCCGTGGTAGACAACTCCAA	0.532													0	0	0	1	0	129	11										A	49929255	G	A	49929255	2	1	101	1	0	0	0	0	0	0	0	1	9891	929	33	1		1	MST1R	3	49929255	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	536	49929255	148093175	35	31477			1	139		4	4	1310	G		4.307853e-08
MBD4	8930	broad.mit.edu	37	chr3	129150350	129150350	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gaaagctgcagagtttaagaTagacttaatttttcatgatt	8	4	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:129150350T>C	uc003emh.1	-	8	1913	c.1737A>G	c.(1735-1737)CTA>CTG	p.L579L	uc003emg.2_5'Flank|MBD4_uc003emi.1_3'UTR|MBD4_uc003emj.1_Silent_p.L573L|MBD4_uc003emk.1_Silent_p.L261L	NM_003925	NP_003916	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	579					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			ovary(1)|lung(1)	2						GAGTTTAAGATAGACTTAATT	0.368								BER_DNA_glycosylases					0	0	0	1	0	125	9										C	129150350	T	C	129150350	2	2	101	1	0	0	0	0	0	0	0	1	9346	1393	49	5		5	MBD4	3	129150350	Silent	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08	79221095	129150350	68872080	36	31478										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	1	0	20	11										G	1803568	C	G	1803568	3	3	101	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		1803568	189350708	37	31479										
NOP14	8602	broad.mit.edu	37	chr4	2954005	2954006	+	Frame_Shift_Ins	INS	-	-	A													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggtgctgccaccctacctccINSagcttcctgaggtgctcctg							TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:2954005_2954006insA	uc003ggj.1	-	6	938_939	c.866_867insT	c.(865-867)CTGfs	p.L289fs	C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Frame_Shift_Ins_p.L35fs|NOP14_uc003ggk.3_Frame_Shift_Ins_p.L289fs|NOP14_uc003ggl.2_Frame_Shift_Ins_p.L289fs|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	289					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						ACCCTACCTCCAGCTTCCTGAG	0.559																		23	85	---	---								A	2954006	-	A	2954005	7	5	101	1	0	1	1	0	0	0	0	0	10536	581	21	0	1758	0	NOP14	4	2954005	Frame_Shift_Ins	INS	-	TCGA-GC-A3BM-01A-11D-A22Z-08	1150437	2954005	188200271	38	31480										
TBC1D1	23216	broad.mit.edu	37	chr4	38051478	38051478	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gtttcgcaaaggaaacttatGaggtatcactcagtgagcac	10	8	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:38051478G>C	uc003gtb.2	+	11	2212	c.1869G>C	c.(1867-1869)ATG>ATC	p.M623I	TBC1D1_uc011byd.1_Missense_Mutation_p.M623I|TBC1D1_uc010ifd.2_Missense_Mutation_p.M370I|TBC1D1_uc011byf.1_Missense_Mutation_p.M494I	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	623						nucleus	Rab GTPase activator activity			ovary(1)	1						GGAAACTTATGAGGTATCACT	0.507													0	0	0	1	0	124	56										C	38051478	G	C	38051478	3	2	101	1	0	0	0	0	1	0	0	0	15594	1290	45	1	1907	1	TBC1D1	4	38051478	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	35097473	38051478	153102798	39	31481										
FRAS1	80144	broad.mit.edu	37	chr4	79205678	79205678	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acagctgtggactgggttttTaccaagctggcagtctctgt	12	9	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:79205678T>C	uc003hlb.2	+	13	1815	c.1375T>C	c.(1375-1377)TAC>CAC	p.Y459H	FRAS1_uc003hkw.2_Missense_Mutation_p.Y459H|FRAS1_uc003hky.1_Missense_Mutation_p.Y163H|FRAS1_uc003hkz.2_Missense_Mutation_p.Y163H|FRAS1_uc003hla.1_5'Flank	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	459	FU 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACTGGGTTTTTACCAAGCTGG	0.488													0	0	0	1	0	53	82										C	79205678	T	C	79205678	3	2	101	1	0	0	0	0	1	0	0	0	6042	1754	61	5	1425	5	FRAS1	4	79205678	Missense_Mutation	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08	41154200	79205678	111948598	40	31482										
PDHA2	5161	broad.mit.edu	37	chr4	96761293	96761293	+	Translation_Start_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gctgccatctacagcactccGtgaagaatatgctggccgcc	10	14	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:96761293G>A	uc003htr.3	+	1	55	c.-8G>A	c.(-10--6)CCGTG>CCATG			NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor						glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ACAGCACTCCGTGAAGAATAT	0.617													0	0	0	1	0	4	16										A	96761293	G	A	96761293	1	1	101	1	0	0	0	0	0	0	0	0	11665	1160	40	2		2	PDHA2	4	96761293	Translation_Start_Site	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	17555615	96761293	94392983	41	31483										
MTTP	4547	broad.mit.edu	37	chr4	100532349	100532349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tggtcgctcacaattatgacCgtttctccaggagtggatct	10	10	3	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:100532349C>T	uc003hvc.3	+	14	2075	c.1819C>T	c.(1819-1821)CGT>TGT	p.R607C	MTTP_uc011cej.1_Missense_Mutation_p.R634C	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	607	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CAATTATGACCGTTTCTCCAG	0.423													0	0	0	1	0	26	46										T	100532349	C	T	100532349	3	4	101	1	0	0	0	0	1	0	0	0	9964	652	23	2	1869	2	MTTP	4	100532349	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	3771056	100532349	90621927	42	31484										
FGG	2266	broad.mit.edu	37	chr4	155527888	155527888	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	actccattgagatggccagcGtgacacttgttcatccacca	8	13	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:155527888G>A	uc003ioj.2	-	8	1239	c.1098C>T	c.(1096-1098)CAC>CAT	p.H366H	FGG_uc003iog.2_Silent_p.H366H|FGG_uc003ioh.2_Silent_p.H374H|FGG_uc010ipx.2_Silent_p.H194H|FGG_uc010ipy.2_Silent_p.H77H|FGG_uc003ioi.2_Silent_p.H77H|FGG_uc003iok.2_Silent_p.H374H	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	366	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GATGGCCAGCGTGACACTTGT	0.363													0	0	0	1	0	29	36										A	155527888	G	A	155527888	2	1	101	1	0	0	0	0	0	0	0	1	5870	1136	40	2		2	FGG	4	155527888	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	54995539	155527888	35626388	43	31485										
ACSL1	2180	broad.mit.edu	37	chr4	185684329	185684329	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gttttcactcacctcgccctCgccctcggcagccatgtaat	7	17	2	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:185684329C>T	uc003iww.2	-	16	1807	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	ACSL1_uc011ckm.1_Missense_Mutation_p.E334K|ACSL1_uc003iwt.1_Missense_Mutation_p.E505K|ACSL1_uc003iwu.1_Missense_Mutation_p.E505K|ACSL1_uc011ckn.1_Missense_Mutation_p.E471K|ACSL1_uc003iws.1_Missense_Mutation_p.E75K	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	505	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ACCTCGCCCTCGCCCTCGGCA	0.478													0	0	0	1	0	8	21										T	185684329	C	T	185684329	3	4	101	1	0	0	0	0	1	0	0	0	177	893	31	1	607	1	ACSL1	4	185684329	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	30156441	185684329	5469947	44	31486										
DNAH5	1767	broad.mit.edu	37	chr5	13753602	13753602	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	atttaacagaagatcacgaaActcttggttaaatggaccag	8	7	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:13753602A>C	uc003jfd.2	-	63	10654	c.10612T>G	c.(10612-10614)TTT>GTT	p.F3538V	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3538					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGATCACGAAACTCTTGGTTA	0.383									Kartagener_syndrome				0	0	0	1	0	33	95										C	13753602	A	C	13753602	3	2	101	1	0	0	0	0	1	0	0	0	4604	43	2	5	3330	5	DNAH5	5	13753602	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08		13753602	167161658	45	31487										
NLN	57486	broad.mit.edu	37	chr5	65118647	65118647	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aacctaatcctgaaacctggGggatctctggacggcatgga	12	10	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:65118647G>A	uc003juf.2	+	13	2135	c.2019G>A	c.(2017-2019)GGG>GGA	p.G673G	NLN_uc003jug.2_Silent_p.G502G|NLN_uc010iww.2_Silent_p.G350G	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	673					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		TGAAACCTGGGGGATCTCTGG	0.408													0	0	0	1	0	28	67										A	65118647	G	A	65118647	2	1	101	1	0	0	0	0	0	0	0	1	10467	1219	43	2		2	NLN	5	65118647	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	51365045	65118647	115796613	46	31488										
SLC30A5	64924	broad.mit.edu	37	chr5	68404192	68404192	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gtaggactttgctgctatttGagcacagtgatattgttgtc	11	6	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:68404192G>C	uc003jvh.2	+	5	577	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	SLC30A5_uc003jvi.2_5'UTR	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	126	Helical; (Potential).				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GCTGCTATTTGAGCACAGTGA	0.333													0	0	0	1	0	15	14										C	68404192	G	C	68404192	3	2	101	1	0	0	0	0	1	0	0	0	14558	1291	45	1	482	1	SLC30A5	5	68404192	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	3285545	68404192	112511068	47	31489										
FAM151B	167555	broad.mit.edu	37	chr5	79837636	79837636	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tttaaacaagccattggaatCaaagttaatctctaagaaga	6	6	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:79837636C>G	uc003kgv.1	+	6	959	c.816C>G	c.(814-816)ATC>ATG	p.I272M	FAM151B_uc010jal.1_RNA	NM_205548	NP_991111	Q6UXP7	F151B_HUMAN	hypothetical protein LOC167555	272											0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		CCATTGGAATCAAAGTTAATC	0.299													0	0	0	1	0	12	9										G	79837636	C	G	79837636	3	3	101	1	0	0	0	0	1	0	0	0	5459	816	29	1	838	1	FAM151B	5	79837636	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	11433444	79837636	101077624	48	31490			2	140		2	2	13	C		5.853166e-05
FAM151B	167555	broad.mit.edu	37	chr5	79837648	79837648	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	attggaatcaaagttaatctCtaagaagaagattctcaatt	6	5	3	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:79837648C>T	uc003kgv.1	+	6	971	c.828C>T	c.(826-828)CTC>CTT	p.L276L	FAM151B_uc010jal.1_RNA	NM_205548	NP_991111	Q6UXP7	F151B_HUMAN	hypothetical protein LOC167555	276											0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		AAGTTAATCTCTAAGAAGAAG	0.299													0	0	0	1	0	10	9										T	79837648	C	T	79837648	2	4	101	1	0	0	0	0	0	0	0	1	5459	900	32	1		1	FAM151B	5	79837648	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	12	79837648	101077612	49	31491			2	140		2	2	13	C		5.853166e-05
GIN1	54826	broad.mit.edu	37	chr5	102442494	102442494	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agtgagggtcctggatatacCatgatgagctccactgtcat	11	9	1	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:102442494C>T	uc003koa.1	-	3	341	c.259G>A	c.(259-261)GGT>AGT	p.G87S	GIN1_uc003kob.1_Intron|GIN1_uc003koc.1_Missense_Mutation_p.G87S	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	87					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		CTGGATATACCATGATGAGCT	0.363													0	0	0	1	0	16	8										T	102442494	C	T	102442494	3	4	101	1	0	0	0	0	1	0	0	0	6386	594	21	2	1333	2	GIN1	5	102442494	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	22604846	102442494	78472766	50	31492										
VDAC1	7416	broad.mit.edu	37	chr5	133326826	133326826	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tggtggtctcagtgttggctGagcctgagcttgtaaattcc	13	8	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:133326826G>A	uc003kyp.1	-	4	236	c.137C>T	c.(136-138)TCA>TTA	p.S46L	VDAC1_uc003kyq.1_Missense_Mutation_p.S46L|VDAC1_uc003kyr.1_Missense_Mutation_p.S46L	NM_003374	NP_003365	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	46	Beta stranded.				apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	AGTGTTGGCTGAGCCTGAGCT	0.478													0	0	0	1	0	27	84										A	133326826	G	A	133326826	3	1	101	1	0	0	0	0	1	0	0	0	17143	1294	45	1	738	1	VDAC1	5	133326826	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	30884332	133326826	47588434	51	31493										
PCDHA5	56143	broad.mit.edu	37	chr5	140201632	140201632	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgtgaattctcggatcgaccGggaggagctgtgccggcgga	17	9	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:140201632G>A	uc003lhl.2	+	1	272	c.272G>A	c.(271-273)CGG>CAG	p.R91Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R91Q|PCDHA5_uc003lhj.1_Missense_Mutation_p.R91Q	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	91	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGATCGACCGGGAGGAGCTG	0.622													0	0	0	1	0	13	243										A	140201632	G	A	140201632	3	1	101	1	0	0	0	0	1	0	0	0	11527	1116	39	2	274	2	PCDHA5	5	140201632	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	6874806	140201632	40713628	52	31494										
SIRT5	23408	broad.mit.edu	37	chr6	13588578	13588578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tttaggtatggcagattttcGaaagttttttgcaaaagcaa	9	4	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:13588578G>A	uc003nay.2	+	4	427	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	SIRT5_uc003naw.2_Missense_Mutation_p.R44Q|SIRT5_uc003nax.2_Intron|SIRT5_uc011dit.1_Missense_Mutation_p.R44Q	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	44	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	GCAGATTTTCGAAAGTTTTTT	0.403													0	0	0	1	0	35	32										A	13588578	G	A	13588578	3	1	101	1	0	0	0	0	1	0	0	0	14341	1058	37	1	137	1	SIRT5	6	13588578	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		13588578	157526489	53	31495										
DEF6	50619	broad.mit.edu	37	chr6	35287672	35287672	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggagcgctacatcgaacggGcgcagcaggagaaggaagag	17	8	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:35287672G>A	uc003okk.2	+	9	1498	c.1459G>A	c.(1459-1461)GCG>ACG	p.A487T	DEF6_uc010jvs.2_Missense_Mutation_p.A462T|DEF6_uc010jvt.2_Missense_Mutation_p.A232T	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	487	Glu-rich.					cytoplasm|nucleus|plasma membrane					0						CATCGAACGGGCGCAGCAGGA	0.617													0	0	0	1	0	4	5										A	35287672	G	A	35287672	3	1	101	1	0	0	0	0	1	0	0	0	4386	1203	42	2	1493	2	DEF6	6	35287672	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	21699094	35287672	135827395	54	31496										
XPO5	57510	broad.mit.edu	37	chr6	43495459	43495459	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgggttttcatctgcagcctCatcttctccactgcagaaaa	7	12	5	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:43495459C>T	uc003ovp.2	-	26	3044	c.2833G>A	c.(2833-2835)GAG>AAG	p.E945K	POLR1C_uc003ovo.1_Intron	NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	945					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TCTGCAGCCTCATCTTCTCCA	0.507													0	0	0	1	0	35	44										T	43495459	C	T	43495459	3	4	101	1	0	0	0	0	1	0	0	0	17444	835	29	1	809	1	XPO5	6	43495459	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	8207787	43495459	127619608	55	31497										
LMBRD1	55788	broad.mit.edu	37	chr6	70447864	70447864	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	atagctgccaacattccaatCaaggtcagagaactgataga	8	9	2	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:70447864C>G	uc003pfa.2	-	7	721	c.606G>C	c.(604-606)TTG>TTC	p.L202F	LMBRD1_uc003pey.2_5'UTR|LMBRD1_uc003pez.2_Missense_Mutation_p.L129F|LMBRD1_uc010kal.2_Missense_Mutation_p.L129F|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	202	Helical; Name=5; (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ACATTCCAATCAAGGTCAGAG	0.289													0	0	0	1	0	12	13										G	70447864	C	G	70447864	3	3	101	1	0	0	0	0	1	0	0	0	8842	825	29	1	1056	1	LMBRD1	6	70447864	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	26952405	70447864	100667203	56	31498										
MDN1	23195	broad.mit.edu	37	chr6	90421882	90421882	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acatctggttcatcgatccaGtaagtattcacttcgactgc	7	11	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:90421882G>A	uc003pnn.1	-	49	7640	c.7524C>T	c.(7522-7524)TAC>TAT	p.Y2508Y		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2508					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CATCGATCCAGTAAGTATTCA	0.408													0	0	0	1	0	94	115										A	90421882	G	A	90421882	2	1	101	1	0	0	0	0	0	0	0	1	9415	1024	36	2		2	MDN1	6	90421882	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	19974018	90421882	80693185	57	31499										
KPNA5	3841	broad.mit.edu	37	chr6	117045538	117045538	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggtgatgatattcaaacacaGgtgagttcaaacttgagtat	10	5	2	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:117045538G>A	uc003pxh.2	+	10	1130	c.999G>A	c.(997-999)CAG>CAA	p.Q333Q		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	330	NLS binding site (minor) (By similarity).|ARM 7.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TTCAAACACAGGTGAGTTCAA	0.279													0	0	0	1	0	14	30										A	117045538	G	A	117045538	2	1	101	1	0	0	0	0	0	0	0	1	8433	1014	35	2		2	KPNA5	6	117045538	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	26623656	117045538	54069529	58	31500										
DNAH11	8701	broad.mit.edu	37	chr7	21751477	21751477	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cacaagatctgggctggaatCcgtgagtatttctttttgtt	10	7	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:21751477C>A	uc003svc.2	+	43	7034	c.7003C>A	c.(7003-7005)CCG>ACG	p.P2335T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2335	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGGCTGGAATCCGTGAGTATT	0.279									Kartagener_syndrome				1	0	3.32936e-07	1	3.38846e-07	19	17										A	21751477	C	A	21751477	3	1	101	1	0	0	0	0	1	0	0	0	4599	869	30	3	7170	3	DNAH11	7	21751477	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		21751477	137387186	59	31501										
FZD9	8326	broad.mit.edu	37	chr7	72848451	72848451	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cgcgggcgcggggctgcgccGtgccaggcggtggagatccc	20	14	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:72848451G>A	uc003tyb.2	+	1	343	c.114G>A	c.(112-114)CCG>CCA	p.P38P		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	38	FZ.|Extracellular (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGGCTGCGCCGTGCCAGGCGG	0.761													0	0	0	1	0	20	17										A	72848451	G	A	72848451	2	1	101	1	0	0	0	0	0	0	0	1	6137	1132	40	2		2	FZD9	7	72848451	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	51096974	72848451	86290212	60	31502										
ZNF277	11179	broad.mit.edu	37	chr7	111981066	111981066	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gaagaaactaaacacacttcGctgctccccgatagaaagac	7	12	0	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:111981066G>A	uc003vge.2	+	11	1278	c.1149G>A	c.(1147-1149)TCG>TCA	p.S383S	ZNF277_uc003vgf.2_Silent_p.S305S|ZNF277_uc003vgg.2_Silent_p.S208S	NM_021994	NP_068834	Q9NRM2	ZN277_HUMAN	zinc finger protein (C2H2 type) 277	383						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(2)	4						AACACACTTCGCTGCTCCCCG	0.423													0	0	0	1	0	44	50										A	111981066	G	A	111981066	2	1	101	1	0	0	0	0	0	0	0	1	17809	1074	38	2		2	ZNF277	7	111981066	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	39132615	111981066	47157597	61	31503										
ARHGEF5	7984	broad.mit.edu	37	chr7	144077079	144077079	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	catttccaacccagaggtccGtgcacagaacctgaaggaag	10	12	0	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:144077079G>A	uc003wel.2	+	15	4842	c.4724G>A	c.(4723-4725)CGT>CAT	p.R1575H	ARHGEF5_uc003wem.2_Missense_Mutation_p.R376H	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1575					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					CCAGAGGTCCGTGCACAGAAC	0.572													0	0	0	1	0	88	106										A	144077079	G	A	144077079	3	1	101	1	0	0	0	0	1	0	0	0	909	1145	40	2	4778	2	ARHGEF5	7	144077079	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	32096013	144077079	15061584	62	31504										
CNTNAP2	26047	broad.mit.edu	37	chr7	147844772	147844772	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cccaacagaaggccacacccGcctggagctctacagccagt	9	17	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:147844772G>A	uc003weu.1	+	17	3260	c.2744G>A	c.(2743-2745)CGC>CAC	p.R915H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	915	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGCCACACCCGCCTGGAGCTC	0.522										HNSCC(39;0.1)			0	0	0	1	0	55	53										A	147844772	G	A	147844772	3	1	101	1	0	0	0	0	1	0	0	0	3647	1087	38	2	2810	2	CNTNAP2	7	147844772	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	3767693	147844772	11293891	63	31505										
MLL3	58508	broad.mit.edu	37	chr7	151843779	151843788	+	Frame_Shift_Del	DEL	TTCTCACACA	TTCTCACACA	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctggagcatttcagacttttTtctcacacatgccacaggct					rs142657994	byFrequency	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			TTCTCACACA	-	TTCTCACACA	TTCTCACACA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:151843779_151843788delTTCTCACACA	uc003wla.2	-	53	14146_14155	c.13927_13936delTGTGTGAGAA	c.(13927-13938)TGTGTGAGAAAAfs	p.C4643fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.C3761fs|MLL3_uc003wkx.2_Frame_Shift_Del_p.C801fs|MLL3_uc003wky.2_Frame_Shift_Del_p.C2207fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4643_4646	FYR C-terminal.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCAGACTTTTTTCTCACACATGCCACAGGC	0.419			N		medulloblastoma						OREG0018460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						25	52	---	---								-	151843788	TTCTCACACA	-	151843779	7	5	101	1	0	1	0	1	0	0	0	0	9622	1850	64	0	827	0	MLL3	7	151843779	Frame_Shift_Del	DEL	TTCTCACACA	TCGA-GC-A3BM-01A-11D-A22Z-08	3999007	151843779	7294884	64	31506										
ADRA1A	148	broad.mit.edu	37	chr8	26627912	26627912	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tccgtcttggagatcctgtaGaaggtctctcttgatcccac	9	12	3	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:26627912G>T	uc003xfh.1	-	2	1591	c.1155C>A	c.(1153-1155)TTC>TTA	p.F385L	ADRA1A_uc003xfc.1_Missense_Mutation_p.F385L|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.F385L|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.F385L	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	385	Cytoplasmic (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	AGATCCTGTAGAAGGTCTCTC	0.557													1	0	3.33393e-45	1	3.49656e-45	106	118										T	26627912	G	T	26627912	3	4	101	1	0	0	0	0	1	0	0	0	334	933	33	3	540	3	ADRA1A	8	26627912	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		26627912	119736110	65	31507										
NKX6-3	157848	broad.mit.edu	37	chr8	41504183	41504183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctccagggcgctcttcttccGccacttggtcctgcggttct	10	16	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:41504183G>A	uc003xoa.2	-	2	197	c.193C>T	c.(193-195)CGG>TGG	p.R65W	NKX6-3_uc010lxa.1_Missense_Mutation_p.R65W	NM_152568	NP_689781	A6NJ46	NKX63_HUMAN	NK6 homeobox 3	195	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.00541)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Esophageal squamous(32;0.0844)|Hepatocellular(245;0.154)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTCTTCTTCCGCCACTTGGTC	0.572													0	0	0	1	0	5	9										A	41504183	G	A	41504183	3	1	101	1	0	0	0	0	1	0	0	0	10459	1086	38	2	218	2	NKX6-3	8	41504183	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	14876271	41504183	104859839	66	31508										
CHD7	55636	broad.mit.edu	37	chr8	61712986	61712986	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggtgaagagaaagcgctacActgaagacctggagttcaag	13	7	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:61712986A>G	uc003xue.2	+	5	2755	c.2278A>G	c.(2278-2280)ACT>GCT	p.T760A		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	760					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAGCGCTACACTGAAGACCT	0.453													0	0	0	1	0	21	21										G	61712986	A	G	61712986	3	3	101	1	0	0	0	0	1	0	0	0	3330	159	6	5	2292	5	CHD7	8	61712986	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	20208803	61712986	84651036	67	31509										
UBR5	51366	broad.mit.edu	37	chr8	103305851	103305851	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acctgctagactgatcagatGatggtcgtggtggtagtggt	15	6	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:103305851G>A	uc003ykr.1	-	34	4604	c.4571C>T	c.(4570-4572)TCA>TTA	p.S1524L	UBR5_uc003yks.1_Missense_Mutation_p.S1524L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1524					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTGATCAGATGATGGTCGTGG	0.443													0	0	0	1	0	36	64										A	103305851	G	A	103305851	3	1	101	1	0	0	0	0	1	0	0	0	16902	1294	45	1	3932	1	UBR5	8	103305851	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	41592865	103305851	43058171	68	31510										
COL22A1	169044	broad.mit.edu	37	chr8	139606405	139606405	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ccttgagatgacttcatgtaCgccgggggcatctgggccag	14	11	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:139606405C>T	uc003yvd.2	-	63	4917	c.4470G>A	c.(4468-4470)GCG>GCA	p.A1490A	COL22A1_uc011ljo.1_Silent_p.A770A	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1490	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ACTTCATGTACGCCGGGGGCA	0.602										HNSCC(7;0.00092)			0	0	0	1	0	40	59										T	139606405	C	T	139606405	2	4	101	1	0	0	0	0	0	0	0	1	3681	523	19	2		2	COL22A1	8	139606405	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	36300554	139606405	6757617	69	31511										
KANK1	23189	broad.mit.edu	37	chr9	734746	734746	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aacttgttttttctcctttcAggtatgaattaagtgaaaag	7	5	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:734746A>G	uc003zgl.1	+	11	3895	c.3246_splice	c.e11-2	p.R1082_splice	KANK1_uc003zgn.1_Splice_Site_p.R1082_splice|KANK1_uc003zgs.1_Splice_Site_p.R924_splice|KANK1_uc010mgx.1_Splice_Site_p.R37_splice|KANK1_uc010mgy.1_5'UTR|KANK1_uc003zgt.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a						negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTCTCCTTTCAGGTATGAATT	0.284													0	0	0	1	0	38	29										G	734746	A	G	734746	5	3	101	1	0	0	0	0	0	0	1	0	7976	202	7	5	3266	5	KANK1	9	734746	Splice_Site	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08		734746	140478685	70	31512										
SLC24A2	25769	broad.mit.edu	37	chr9	19573435	19573435	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggatggtgtcatttcaacatCtgtgctggtgctgtttggaa	13	6	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:19573435C>T	uc003zoa.1	-	6	1323	c.1261G>A	c.(1261-1263)GAT>AAT	p.D421N	SLC24A2_uc003zob.1_Missense_Mutation_p.D404N	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	421	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		ATTTCAACATCTGTGCTGGTG	0.303													0	0	0	1	0	48	16										T	19573435	C	T	19573435	3	4	101	1	0	0	0	0	1	0	0	0	14466	913	32	1	744	1	SLC24A2	9	19573435	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	18838689	19573435	121639996	71	31513										
CDKN2A	1029	broad.mit.edu	37	chr9	21971092	21971093	+	Frame_Shift_Del	DEL	CC	CC	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ccaccagcgtgtccaggaagCcctcccgggcagcgtcgtgc					rs137854599		TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			CC	-	CC	CC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:21971092_21971093delCC	uc003zpk.2	-	2	477_478	c.265_266delGG	c.(265-267)GGCfs	p.G89fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Del_p.G144fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	89	ANK 3.		G -> D (in CMM2; somatic mutation).|G -> S (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.G89S(4)|p.H83fs*2(2)|p.D84_F90del(1)|p.V82_G89>G(1)|p.G89V(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.G89fs*57(1)|p.G89G(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GTCCAGGAAGCCCTCCCGGGCA	0.757		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)								17	2	---	---								-	21971093	CC	-	21971092	7	5	101	1	0	1	0	1	0	0	0	0	3161	739	26	0	212	0	CDKN2A	9	21971092	Frame_Shift_Del	DEL	CC	TCGA-GC-A3BM-01A-11D-A22Z-08	2397657	21971092	119242339	72	31514										
VCP	7415	broad.mit.edu	37	chr9	35061086	35061086	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctcatcctctaggtcaatgaGatccatcttcttgcggatgg	9	11	5	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:35061086G>A	uc003zvy.2	-	11	1674	c.1285C>T	c.(1285-1287)CTC>TTC	p.L429F	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.L98F|VCP_uc010mki.1_Missense_Mutation_p.L384F	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	429					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGTCAATGAGATCCATCTTC	0.537													0	0	0	1	0	139	131										A	35061086	G	A	35061086	3	1	101	1	0	0	0	0	1	0	0	0	17137	942	33	1	1163	1	VCP	9	35061086	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	13089994	35061086	106152345	73	31515										
RG9MTD3	158234	broad.mit.edu	37	chr9	37768130	37768130	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	atggttcaaacaaaaaagctGacaggccattttggatctgc	9	8	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:37768130G>C	uc004aai.2	+	5	555	c.478G>C	c.(478-480)GAC>CAC	p.D160H	RG9MTD3_uc011lqo.1_Intron|RG9MTD3_uc011lqp.1_Missense_Mutation_p.D82H|RG9MTD3_uc011lqq.1_Missense_Mutation_p.D49H|RG9MTD3_uc004aaj.2_RNA|RG9MTD3_uc004aak.2_Missense_Mutation_p.D65H	NM_144964	NP_659401	Q6PF06	RG9D3_HUMAN	RNA (guanine-9-) methyltransferase domain	160							methyltransferase activity				0				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)		CAAAAAAGCTGACAGGCCATT	0.413													0	0	0	1	0	77	100										C	37768130	G	C	37768130	3	2	101	1	0	0	0	0	1	0	0	0	13273	1290	45	1	492	1	RG9MTD3	9	37768130	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	2707044	37768130	103445301	74	31516										
XPA	7507	broad.mit.edu	37	chr9	100459547	100459547	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttgctctaaagccgccgcctCcggcaaagccccgtcggccg	11	18	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:100459547C>T	uc004axr.3	-	1	145	c.28G>A	c.(28-30)GAG>AAG	p.E10K	XPA_uc004axs.3_RNA	NM_000380	NP_000371	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	10	Interaction with CEP164 and required for UV resistance.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity			breast(1)	1		Acute lymphoblastic leukemia(62;0.158)				GCCGCCGCCTCCGGCAAAGCC	0.736			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				0	0	0	1	0	21	20										T	100459547	C	T	100459547	3	4	101	1	0	0	0	0	1	0	0	0	17437	864	30	1	817	1	XPA	9	100459547	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	62691417	100459547	40753884	75	31517										
SPTAN1	6709	broad.mit.edu	37	chr9	131379944	131379944	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agaagctgctggtgggctcaGaggactacggccgggaccta	16	10	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131379944G>C	uc004bvl.3	+	41	5481	c.5368G>C	c.(5368-5370)GAG>CAG	p.E1790Q	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1795Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1770Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1790	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGTGGGCTCAGAGGACTACGG	0.572													0	0	0	1	0	27	6										C	131379944	G	C	131379944	3	2	101	1	0	0	0	0	1	0	0	0	15116	943	33	1	5545	1	SPTAN1	9	131379944	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	30920397	131379944	9833487	76	31518			3	141		5	5	1283	N	G	6.309948e-11
SPTAN1	6709	broad.mit.edu	37	chr9	131379988	131379988	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggcgtgcagaacctgaggaaGaagcacaagcggctggaagc	16	9	0	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131379988G>T	uc004bvl.3	+	41	5525	c.5412G>T	c.(5410-5412)AAG>AAT	p.K1804N	SPTAN1_uc004bvm.3_Missense_Mutation_p.K1809N|SPTAN1_uc004bvn.3_Missense_Mutation_p.K1784N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1804	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ACCTGAGGAAGAAGCACAAGC	0.597													1	0	3.76604e-16	1	3.87879e-16	39	8										T	131379988	G	T	131379988	3	4	101	1	0	0	0	0	1	0	0	0	15116	933	33	3	5589	3	SPTAN1	9	131379988	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	44	131379988	9833443	77	31519			3	141		5	5	1283	N	G	6.309948e-11
SPTAN1	6709	broad.mit.edu	37	chr9	131380380	131380380	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aagagctgaagcagctggcaGctgcccggtgagtagtcaga	15	9	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131380380G>T	uc004bvl.3	+	42	5691	c.5578G>T	c.(5578-5580)GCT>TCT	p.A1860S	SPTAN1_uc004bvm.3_Missense_Mutation_p.A1865S|SPTAN1_uc004bvn.3_Missense_Mutation_p.A1840S	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1860	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCAGCTGGCAGCTGCCCGGTG	0.612													1	0	6.04917e-29	1	6.26782e-29	43	4										T	131380380	G	T	131380380	3	4	101	1	0	0	0	0	1	0	0	0	15116	971	34	4	5759	4	SPTAN1	9	131380380	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	392	131380380	9833051	78	31520			3	141		5	5	1283	N	G	6.309948e-11
SPTAN1	6709	broad.mit.edu	37	chr9	131381207	131381207	+	Frame_Shift_Del	DEL	G	G	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tttgtagccaatgtggaagaGgaagaagcctggatcaatga							TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131381207delG	uc004bvl.3	+	43	5756	c.5643delG	c.(5641-5643)GAGfs	p.E1881fs	SPTAN1_uc004bvm.3_Frame_Shift_Del_p.E1886fs|SPTAN1_uc004bvn.3_Frame_Shift_Del_p.E1861fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1881	Spectrin 20.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATGTGGAAGAGGAAGAAGCCT	0.498																		41	7	---	---								-	131381207	G	-	131381207	7	5	101	1	0	1	0	1	0	0	0	0	15116	991	35	0	5828	0	SPTAN1	9	131381207	Frame_Shift_Del	DEL	G	TCGA-GC-A3BM-01A-11D-A22Z-08	827	131381207	9832224	79	31521			3	141		5	5	1283	N	G	6.309948e-11
SPTAN1	6709	broad.mit.edu	37	chr9	131381226	131381226	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggaagaagcctggatcaatGagaaaatgaccctggtggcc	13	8	1	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131381226G>A	uc004bvl.3	+	43	5775	c.5662G>A	c.(5662-5664)GAG>AAG	p.E1888K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1893K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1868K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1888	Spectrin 20.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CTGGATCAATGAGAAAATGAC	0.498													0	0	0	1	0	37	6										A	131381226	G	A	131381226	3	1	101	1	0	0	0	0	1	0	0	0	15116	1291	45	1	5847	1	SPTAN1	9	131381226	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	19	131381226	9832205	80	31522			3	141		5	5	1283	N	G	6.309948e-11
TOR1B	27348	broad.mit.edu	37	chr9	132565654	132565654	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acatctactgccgcttcgccGagtgctgccgcgaggagcgg	14	14	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:132565654G>A	uc004byk.1	+	1	223	c.163G>A	c.(163-165)GAG>AAG	p.E55K		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	55					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				CCGCTTCGCCGAGTGCTGCCG	0.602													0	0	0	1	0	21	2										A	132565654	G	A	132565654	3	1	101	1	0	0	0	0	1	0	0	0	16371	1059	37	1	165	1	TOR1B	9	132565654	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	1184428	132565654	8647777	81	31523			4	142	1184428	2	2	13	G		5.853166e-05
TOR1B	27348	broad.mit.edu	37	chr9	132565666	132565666	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gcttcgccgagtgctgccgcGaggagcggccgctcaacgct	15	15	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:132565666G>A	uc004byk.1	+	1	235	c.175G>A	c.(175-177)GAG>AAG	p.E59K		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	59					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				GTGCTGCCGCGAGGAGCGGCC	0.602													0	0	0	1	0	20	3										A	132565666	G	A	132565666	3	1	101	1	0	0	0	0	1	0	0	0	16371	1059	37	1	177	1	TOR1B	9	132565666	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	12	132565666	8647765	82	31524			4	142	1184428	2	2	13	G		5.853166e-05
CUBN	8029	broad.mit.edu	37	chr10	16883020	16883020	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	caaaacgttccagccaagttCgcattttcactatccccatc	4	15	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:16883020C>T	uc001ioo.2	-	61	9742	c.9690G>A	c.(9688-9690)GCG>GCA	p.A3230A		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3230	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGCCAAGTTCGCATTTTCAC	0.368													0	0	0	1	0	14	15										T	16883020	C	T	16883020	2	4	101	1	0	0	0	0	0	0	0	1	4051	871	31	1		1	CUBN	10	16883020	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		16883020	118651727	83	31525										
MASTL	84930	broad.mit.edu	37	chr10	27459681	27459681	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tagaagcatcaaagaatcctCttttgaagaatcaaatattg	6	6	3	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:27459681C>G	uc001itm.2	+	8	2432	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	MASTL_uc001itl.2_Missense_Mutation_p.S598C|MASTL_uc009xkw.1_Missense_Mutation_p.S598C|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	598	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						AAAGAATCCTCTTTTGAAGAA	0.368													0	0	0	1	0	10	23										G	27459681	C	G	27459681	3	3	101	1	0	0	0	0	1	0	0	0	9328	913	32	1	1823	1	MASTL	10	27459681	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	10576661	27459681	108075066	84	31526										
RET	5979	broad.mit.edu	37	chr10	43623613	43623613	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctgtaccactcacgagagctGatggcactaacactgggttt	10	11	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:43623613G>C	uc001jal.2	+	20	3431	c.3241G>C	c.(3241-3243)GAT>CAT	p.D1081H		NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	1081	Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CACGAGAGCTGATGGCACTAA	0.438		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	1	0	41	82										C	43623613	G	C	43623613	3	2	101	1	0	0	0	0	1	0	0	0	13235	1290	45	1	3351	1	RET	10	43623613	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	16163932	43623613	91911134	85	31527										
ERCC6	2074	broad.mit.edu	37	chr10	50740776	50740776	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggctctactgcctggatctGatgtcggtcgatgtgcagca	13	10	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:50740776G>A	uc001jhs.3	-	2	389	c.235C>T	c.(235-237)CAG>TAG	p.Q79*	PGBD3_uc009xoe.2_Nonsense_Mutation_p.Q79*|PGBD3_uc001jhu.2_Nonsense_Mutation_p.Q79*	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	79					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GCCTGGATCTGATGTCGGTCG	0.622								Direct_reversal_of_damage|NER					0	0	0	1	0	25	33										A	50740776	G	A	50740776	4	1	101	1	0	0	0	0	0	1	0	0	5217	1299	45	1	4326	1	ERCC6	10	50740776	Nonsense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	7117163	50740776	84793971	86	31528										
PRF1	5551	broad.mit.edu	37	chr10	72360386	72360386	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgggcccgccagttggtgagCgccagaggcaggcgctggag	19	11	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:72360386C>T	uc009xqg.2	-	2	434	c.273G>A	c.(271-273)GCG>GCA	p.A91A	PRF1_uc001jrf.3_Silent_p.A91A	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	91	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						AGTTGGTGAGCGCCAGAGGCA	0.657			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	1	0	18	16										T	72360386	C	T	72360386	2	4	101	1	0	0	0	0	0	0	0	1	12478	755	27	2		2	PRF1	10	72360386	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	21619610	72360386	63174361	87	31529										
SORCS3	22986	broad.mit.edu	37	chr10	106916969	106916969	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gaagacatacatcacttacaAcaaaggcagggattggcgcc	10	10	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:106916969A>T	uc001kyi.1	+	10	1783	c.1556A>T	c.(1555-1557)AAC>ATC	p.N519I		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	519	BNR 4.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATCACTTACAACAAAGGCAGG	0.512													0	0	0	1	0	27	24										T	106916969	A	T	106916969	3	4	101	1	0	0	0	0	1	0	0	0	14932	43	2	5	1594	5	SORCS3	10	106916969	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	34556583	106916969	28617778	88	31530										
C10orf82	143379	broad.mit.edu	37	chr10	118424359	118424359	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttttggccatgacagtgtatCtcgtgccacagccaaattca	8	11	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:118424359C>G	uc001lcr.2	-	4	429	c.374G>C	c.(373-375)AGA>ACA	p.R125T	C10orf82_uc001lcs.1_3'UTR	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	125											0				all cancers(201;0.0143)		GACAGTGTATCTCGTGCCACA	0.522													0	0	0	1	0	49	64										G	118424359	C	G	118424359	3	3	101	1	0	0	0	0	1	0	0	0	1620	913	32	1	98	1	C10orf82	10	118424359	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	11507390	118424359	17110388	89	31531										
KNDC1	85442	broad.mit.edu	37	chr10	135020668	135020668	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acgcggaacgctggggcctgGagccctgcaccctcccagtg	14	16	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:135020668G>A	uc001llz.1	+	20	3608	c.3607G>A	c.(3607-3609)GAG>AAG	p.E1203K	KNDC1_uc001lma.1_3'UTR	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1203					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CTGGGGCCTGGAGCCCTGCAC	0.657													0	0	0	1	0	4	8										A	135020668	G	A	135020668	3	1	101	1	0	0	0	0	1	0	0	0	8426	1175	41	1	3685	1	KNDC1	10	135020668	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	16596309	135020668	514079	90	31532										
PLEKHA7	144100	broad.mit.edu	37	chr11	16838384	16838384	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gtgccctccttggagaatccCccagcgagatgtccacactc	9	16	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:16838384C>T	uc001mmo.2	-	11	1844	c.1829G>A	c.(1828-1830)GGG>GAG	p.G610E	PLEKHA7_uc010rcu.1_Missense_Mutation_p.G610E|PLEKHA7_uc010rcv.1_Missense_Mutation_p.G184E|PLEKHA7_uc001mmn.2_Missense_Mutation_p.G318E	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	610	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TGGAGAATCCCCCAGCGAGAT	0.657													0	0	0	1	0	49	5										T	16838384	C	T	16838384	3	4	101	1	0	0	0	0	1	0	0	0	12061	623	22	2	1588	2	PLEKHA7	11	16838384	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		16838384	118168132	91	31533										
ALX4	60529	broad.mit.edu	37	chr11	44296955	44296955	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agctgttcccgcgcatacacGtctgggtagtgggtcttctg	13	11	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:44296955G>A	uc001myb.2	-	2	824	c.720C>T	c.(718-720)GAC>GAT	p.D240D		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	240	Homeobox.				hair follicle development						0						GCGCATACACGTCTGGGTAGT	0.617													0	0	0	1	0	106	13										A	44296955	G	A	44296955	2	1	101	1	0	0	0	0	0	0	0	1	558	1136	40	2		2	ALX4	11	44296955	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	27458571	44296955	90709561	92	31534										
PATL1	219988	broad.mit.edu	37	chr11	59415362	59415362	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ccttttcggatacacatgatCtgtacaaagtggtcatcact	7	10	3	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:59415362C>T	uc001noe.3	-	15	1901	c.1758G>A	c.(1756-1758)CAG>CAA	p.Q586Q	PATL1_uc009yms.1_Silent_p.Q556Q	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	586	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1						TACACATGATCTGTACAAAGT	0.438													0	0	0	1	0	20	30										T	59415362	C	T	59415362	2	4	101	1	0	0	0	0	0	0	0	1	11475	912	32	1		1	PATL1	11	59415362	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	15118407	59415362	75591154	93	31535										
MS4A12	54860	broad.mit.edu	37	chr11	60264894	60264894	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctggatttcaacagcctctgGgttcaatcaacttagaaaac	7	10	4	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:60264894G>T	uc001npr.2	+	2	160	c.103G>T	c.(103-105)GGT>TGT	p.G35C	MS4A12_uc009ynb.2_Missense_Mutation_p.G35C	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	35	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						ACAGCCTCTGGGTTCAATCAA	0.507													1	0	4.81439e-37	1	5.01864e-37	80	86										T	60264894	G	T	60264894	3	4	101	1	0	0	0	0	1	0	0	0	9856	1232	43	4	105	4	MS4A12	11	60264894	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	849532	60264894	74741622	94	31536										
INPPL1	3636	broad.mit.edu	37	chr11	71949104	71949104	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggctccgtgcctgcagggcGggcgggccagcgggctgggc	21	13	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:71949104G>T	uc001osf.2	+	27	3718	c.3571G>T	c.(3571-3573)GGG>TGG	p.G1191W	INPPL1_uc001osg.2_Missense_Mutation_p.G949W	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1191					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CCTGCAGGGCGGGCGGGCCAG	0.657											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.000586117	1	0.000589545	23	19										T	71949104	G	T	71949104	3	4	101	1	0	0	0	0	1	0	0	0	7761	1116	39	4	3677	4	INPPL1	11	71949104	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	11684210	71949104	63057412	95	31537										
PPME1	51400	broad.mit.edu	37	chr11	73958134	73958134	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgttttctaggtgttgatagAttggataaagatctgaccat	10	4	2	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:73958134A>G	uc001ouw.2	+	11	1074	c.975A>G	c.(973-975)AGA>AGG	p.R325R	PPME1_uc009yty.2_Silent_p.R209R|PPME1_uc001oux.2_Silent_p.R138R	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	325					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					GTGTTGATAGATTGGATAAAG	0.348													0	0	0	1	0	15	17										G	73958134	A	G	73958134	2	3	101	1	0	0	0	0	0	0	0	1	12347	330	12	5		5	PPME1	11	73958134	Silent	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	2009030	73958134	61048382	96	31538										
P4HA3	283208	broad.mit.edu	37	chr11	74009284	74009284	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	taagcaaaggccaagtgatcCaaggcatcttctagacttgc	9	10	2	2	rs142768884	byFrequency	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:74009284C>G	uc001ouz.2	-	4	733	c.690G>C	c.(688-690)TTG>TTC	p.L230F	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Missense_Mutation_p.L230F	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	230	TPR.					endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					CCAAGTGATCCAAGGCATCTT	0.413													0	0	0	1	0	48	87										G	74009284	C	G	74009284	3	3	101	1	0	0	0	0	1	0	0	0	11358	593	21	4	984	4	P4HA3	11	74009284	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	51150	74009284	60997232	97	31539										
FAT3	120114	broad.mit.edu	37	chr11	92531924	92531924	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gatcctgactctgaggtaccCcctgaactgacatacagcct	8	14	1	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:92531924C>T	uc001pdj.3	+	9	5762	c.5745C>T	c.(5743-5745)CCC>CCT	p.P1915P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1915	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTGAGGTACCCCCTGAACTGA	0.418										TCGA Ovarian(4;0.039)			0	0	0	1	0	25	3										T	92531924	C	T	92531924	2	4	101	1	0	0	0	0	0	0	0	1	5691	610	22	2		2	FAT3	11	92531924	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	18522640	92531924	42474592	98	31540										
BUD13	84811	broad.mit.edu	37	chr11	116633513	116633513	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gagtcatgacgggcccttctGagttgctgtgtgtctgaaga	14	8	3	4			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:116633513G>A	uc001ppn.2	-	4	826	c.792C>T	c.(790-792)CTC>CTT	p.L264L	BUD13_uc001ppo.2_Intron|BUD13_uc009yzc.2_Silent_p.L264L	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	264	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGCCCTTCTGAGTTGCTGTG	0.517													0	0	0	1	0	140	14										A	116633513	G	A	116633513	2	1	101	1	0	0	0	0	0	0	0	1	1573	1277	45	1		1	BUD13	11	116633513	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	24101589	116633513	18373003	99	31541										
GRIN2B	2904	broad.mit.edu	37	chr12	13716716	13716716	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctccgctccttgtagatgtcGgtcaggtctacgtgctccca	10	14	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:13716716G>A	uc001rbt.2	-	13	3635	c.3456C>T	c.(3454-3456)ACC>ACT	p.T1152T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1152	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTAGATGTCGGTCAGGTCTA	0.577													0	0	0	1	0	66	33										A	13716716	G	A	13716716	2	1	101	1	0	0	0	0	0	0	0	1	6780	1103	39	2		2	GRIN2B	12	13716716	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		13716716	120135179	100	31542										
MCRS1	10445	broad.mit.edu	37	chr12	49957275	49957275	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttgctaaacagggccttgctCtggatggctgcaatagcctc	11	11	1	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:49957275C>G	uc001ruk.1	-	7	803	c.612G>C	c.(610-612)CAG>CAC	p.Q204H	MCRS1_uc001rui.1_Missense_Mutation_p.Q217H|MCRS1_uc001ruj.1_Missense_Mutation_p.Q191H|MCRS1_uc001rul.1_Missense_Mutation_p.Q204H|MCRS1_uc009zlj.1_Missense_Mutation_p.Q13H|MCRS1_uc001rum.1_Missense_Mutation_p.Q191H|MCRS1_uc001run.1_Missense_Mutation_p.Q204H	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	204					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						GGGCCTTGCTCTGGATGGCTG	0.597													0	0	0	1	0	6	13										G	49957275	C	G	49957275	3	3	101	1	0	0	0	0	1	0	0	0	9399	912	32	1	812	1	MCRS1	12	49957275	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	36240559	49957275	83894620	101	31543										
KIF5A	3798	broad.mit.edu	37	chr12	57963097	57963097	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gattctccaggactctctcgGgggaaactgccggacgacta	12	12	2	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:57963097G>A	uc001sor.1	+	10	1086	c.878G>A	c.(877-879)GGG>GAG	p.G293E	KIF5A_uc010srr.1_Missense_Mutation_p.G204E	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	293	Kinesin-motor.|Microtubule-binding.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						GACTCTCTCGGGGGAAACTGC	0.478													0	0	0	1	0	22	71										A	57963097	G	A	57963097	3	1	101	1	0	0	0	0	1	0	0	0	8305	1232	43	2	916	2	KIF5A	12	57963097	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	8005822	57963097	75888798	102	31544										
MYF5	4617	broad.mit.edu	37	chr12	81110945	81110945	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttggggacgagtttgtgccgCgagtggctgccttcggagcg	18	9	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:81110945C>T	uc001szg.2	+	1	238	c.103C>T	c.(103-105)CGA>TGA	p.R35*		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	35					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GTTTGTGCCGCGAGTGGCTGC	0.622													0	0	0	1	0	46	19										T	81110945	C	T	81110945	4	4	101	1	0	0	0	0	0	1	0	0	10027	760	27	2	105	2	MYF5	12	81110945	Nonsense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	23147848	81110945	52740950	103	31545										
TRPV4	59341	broad.mit.edu	37	chr12	110238434	110238434	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cctccttaccaaagtagaagTagcccccctcatccttgggc	7	16	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:110238434T>C	uc001tpj.1	-	4	937	c.842A>G	c.(841-843)TAC>TGC	p.Y281C	TRPV4_uc001tpg.1_Missense_Mutation_p.Y247C|TRPV4_uc001tph.1_Intron|TRPV4_uc001tpi.1_Intron|TRPV4_uc001tpk.1_Missense_Mutation_p.Y281C|TRPV4_uc001tpl.1_Missense_Mutation_p.Y281C	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	281	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AAAGTAGAAGTAGCCCCCCTC	0.612													0	0	0	1	0	61	28										C	110238434	T	C	110238434	3	2	101	1	0	0	0	0	1	0	0	0	16595	1638	57	5	1821	5	TRPV4	12	110238434	Missense_Mutation	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08	29127489	110238434	23613461	104	31546										
SACS	26278	broad.mit.edu	37	chr13	23908464	23908464	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tattcataaacaagtctttgCgggatggaatcaattcatga	8	6	4	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:23908464C>T	uc001uon.2	-	10	10140	c.9551G>A	c.(9550-9552)CGC>CAC	p.R3184H	SACS_uc001uoo.2_Missense_Mutation_p.R3037H|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3184					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CAAGTCTTTGCGGGATGGAAT	0.343													0	0	0	1	0	11	13										T	23908464	C	T	23908464	3	4	101	1	0	0	0	0	1	0	0	0	13804	768	27	2	4192	2	SACS	13	23908464	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		23908464	91261414	105	31547										
PABPC3	5042	broad.mit.edu	37	chr13	25671775	25671775	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gcagcgtgttgctaacacatCaacacagacagtgggtccac	10	12	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:25671775C>G	uc001upy.2	+	1	1500	c.1439C>G	c.(1438-1440)TCA>TGA	p.S480*		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	480					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GCTAACACATCAACACAGACA	0.433													0	0	0	1	0	31	55										G	25671775	C	G	25671775	4	3	101	1	0	0	0	0	0	1	0	0	11365	838	29	1	1441	1	PABPC3	13	25671775	Nonsense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	1763311	25671775	89498103	106	31548										
FLT1	2321	broad.mit.edu	37	chr13	29012388	29012388	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gtaacagtgatgttaggtgaCgtaacccggcagggaatgac	14	7	0	3	rs116486684	by1000genomes	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:29012388C>T	uc001usb.3	-	4	768	c.483G>A	c.(481-483)ACG>ACA	p.T161T	FLT1_uc010aar.1_Silent_p.T161T|FLT1_uc001usc.3_Silent_p.T161T|FLT1_uc010tdp.1_Silent_p.T161T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	161	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGTTAGGTGACGTAACCCGGC	0.398													0	0	0	1	0	11	11										T	29012388	C	T	29012388	2	4	101	1	0	0	0	0	0	0	0	1	5941	523	19	2		2	FLT1	13	29012388	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	3340613	29012388	86157490	107	31549										
HS6ST3	266722	broad.mit.edu	37	chr13	96743176	96743176	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctcactctcctcttcgtggtCatcatgtaccagtacgtgtc	7	14	5	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:96743176C>G	uc001vmw.2	+	1	84	c.60C>G	c.(58-60)GTC>GTG	p.V20V		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	20	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					TCTTCGTGGTCATCATGTACC	0.438													0	0	0	1	0	16	27										G	96743176	C	G	96743176	2	3	101	1	0	0	0	0	0	0	0	1	7372	813	29	1		1	HS6ST3	13	96743176	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	67730788	96743176	18426702	108	31550										
COL4A2	1284	broad.mit.edu	37	chr13	111164350	111164350	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gcagctgtctagaggacttcCgcgccacaccattcatcgaa	9	14	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:111164350C>T	uc001vqx.2	+	48	5240	c.4951C>T	c.(4951-4953)CGC>TGC	p.R1651C		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1651	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGAGGACTTCCGCGCCACACC	0.617													0	0	0	1	0	34	74										T	111164350	C	T	111164350	3	4	101	1	0	0	0	0	1	0	0	0	3690	652	23	2	5137	2	COL4A2	13	111164350	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	14421174	111164350	4005528	109	31551										
OR6S1	341799	broad.mit.edu	37	chr14	21108981	21108981	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttacgtaaggcatagatgaaTggattcaacagtggtgtcac	11	6	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr14:21108981T>C	uc001vxv.1	-	1	870	c.870A>G	c.(868-870)CCA>CCG	p.P290P		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CATAGATGAATGGATTCAACA	0.433													0	0	0	1	0	78	102										C	21108981	T	C	21108981	2	2	101	1	0	0	0	0	0	0	0	1	11209	1451	51	5		5	OR6S1	14	21108981	Silent	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08		21108981	86240559	110	31552										
GPR137C	283554	broad.mit.edu	37	chr14	53101795	53101798	+	Frame_Shift_Del	DEL	AACA	AACA	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cttgtagtaatttagatttgAacaatcatcatagcttatat							TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr14:53101795_53101798delAACA	uc001wzu.3	+	7	1252_1255	c.1252_1255delAACA	c.(1252-1257)AACAATfs	p.N418fs	GPR137C_uc001wzt.3_Frame_Shift_Del_p.N434fs	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	418_419	Cytoplasmic (Potential).					integral to membrane					0	Breast(41;0.0716)					TTTAGATTTGAACAATCATCATAG	0.382																		15	52	---	---								-	53101798	AACA	-	53101795	7	5	101	1	0	1	0	1	0	0	0	0	6647	246	9	0	1278	0	GPR137C	14	53101795	Frame_Shift_Del	DEL	AACA	TCGA-GC-A3BM-01A-11D-A22Z-08	31992814	53101795	54247745	111	31553										
FBXO34	55030	broad.mit.edu	37	chr14	55817949	55817949	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gcgaaccagtccgtgtccttGacatggtagccaagttggag	13	10	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr14:55817949G>C	uc001xbu.2	+	2	1086	c.841G>C	c.(841-843)GAC>CAC	p.D281H	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.D281H	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	281										ovary(2)|lung(2)|skin(1)	5						CCGTGTCCTTGACATGGTAGC	0.552													0	0	0	1	0	88	81										C	55817949	G	C	55817949	3	2	101	1	0	0	0	0	1	0	0	0	5744	1290	45	1	843	1	FBXO34	14	55817949	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	2716154	55817949	51531591	112	31554										
ATP10A	57194	broad.mit.edu	37	chr15	25969114	25969114	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aggagcttccatcagacttgGggacataaaataatgacttc	9	8	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:25969114G>A	uc010ayu.2	-	6	1140	c.1034C>T	c.(1033-1035)CCC>CTC	p.P345L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	345	Extracellular (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ATCAGACTTGGGGACATAAAA	0.373													0	0	0	1	0	44	74										A	25969114	G	A	25969114	3	1	101	1	0	0	0	0	1	0	0	0	1116	1232	43	2	3529	2	ATP10A	15	25969114	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		25969114	76562278	113	31555										
GABRA5	2558	broad.mit.edu	37	chr15	27126006	27126006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttaaaagcttttcacagatgCcaaccagttcagtgaaagat	7	8	2	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:27126006C>T	uc001zbd.1	+	5	439	c.100C>T	c.(100-102)CCA>TCA	p.P34S	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	34	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCACAGATGCCAACCAGTTC	0.418													0	0	0	1	0	21	39										T	27126006	C	T	27126006	3	4	101	1	0	0	0	0	1	0	0	0	6164	739	26	2	106	2	GABRA5	15	27126006	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	1156892	27126006	75405386	114	31556										
RFX7	64864	broad.mit.edu	37	chr15	56388173	56388173	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ttttatttcaatgacaccttCatttgaaggtttctgcagtg	7	7	3	2	rs140370063	by1000genomes	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:56388173C>T	uc010bfn.2	-	9	1753	c.1753G>A	c.(1753-1755)GAA>AAA	p.E585K	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.E399K	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	488					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						ATGACACCTTCATTTGAAGGT	0.458													0	0	0	1	0	21	14										T	56388173	C	T	56388173	3	4	101	1	0	0	0	0	1	0	0	0	13268	835	29	1	2633	1	RFX7	15	56388173	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	29262167	56388173	46143219	115	31557										
C15orf27	123591	broad.mit.edu	37	chr15	76496330	76496330	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agccgtcctctgagcccggcCcttctcccccgccgctgcca	9	22	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:76496330C>T	uc002bbq.2	+	11	1425	c.1270C>T	c.(1270-1272)CCT>TCT	p.P424S	C15orf27_uc010bkp.2_Missense_Mutation_p.P240S|C15orf27_uc002bbr.2_Missense_Mutation_p.P240S|C15orf27_uc002bbs.2_Missense_Mutation_p.P102S	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	424						integral to membrane					0						TGAGCCCGGCCCTTCTCCCCC	0.701													0	0	0	1	0	28	38										T	76496330	C	T	76496330	3	4	101	1	0	0	0	0	1	0	0	0	1788	623	22	2	1308	2	C15orf27	15	76496330	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	20108157	76496330	26035062	116	31558										
MKL2	57496	broad.mit.edu	37	chr16	14339510	14339510	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tctgccttctagcctggatgActtaaaggtgacaattgcaa	9	9	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr16:14339510A>T	uc010uza.1	+	11	1360	c.1205A>T	c.(1204-1206)GAC>GTC	p.D402V	MKL2_uc002dcg.2_Missense_Mutation_p.D402V|MKL2_uc002dcj.2_5'Flank	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	391	SAP.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						AGCCTGGATGACTTAAAGGTG	0.433													0	0	0	1	0	61	94										T	14339510	A	T	14339510	3	4	101	1	0	0	0	0	1	0	0	0	9602	275	10	5	1239	5	MKL2	16	14339510	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08		14339510	76015243	117	31559										
SLC9A5	6553	broad.mit.edu	37	chr16	67289057	67289057	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctctttatcatcgtctttggCgagtccctgctcaacgatgc	8	13	4	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr16:67289057C>T	uc002esm.2	+	3	687	c.624C>T	c.(622-624)GGC>GGT	p.G208G	SLC9A5_uc010cee.2_5'UTR|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	208	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		TCGTCTTTGGCGAGTCCCTGC	0.592													0	0	0	1	0	67	72										T	67289057	C	T	67289057	2	4	101	1	0	0	0	0	0	0	0	1	14717	755	27	2		2	SLC9A5	16	67289057	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	52949547	67289057	23065696	118	31560										
MYH1	4619	broad.mit.edu	37	chr17	10398335	10398335	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cgatgctgcaggtccttcacCgtctgttccaggttcttctt	9	13	4	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:10398335C>T	uc002gmo.2	-	37	5473	c.5379G>A	c.(5377-5379)ACG>ACA	p.T1793T	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1793	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGTCCTTCACCGTCTGTTCCA	0.557													0	0	0	1	0	119	12										T	10398335	C	T	10398335	2	4	101	1	0	0	0	0	0	0	0	1	10029	639	23	2		2	MYH1	17	10398335	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		10398335	70796875	119	31561										
ALKBH5	54890	broad.mit.edu	37	chr17	18088053	18088053	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gcgacgtggacgagatccccGagtgggtgcaccagctggtg	17	11	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:18088053G>A	uc010cpw.2	+	1	1187	c.496G>A	c.(496-498)GAG>AAG	p.E166K	uc002gsn.2_RNA|ALKBH5_uc010cpx.2_5'Flank	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	166						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					CGAGATCCCCGAGTGGGTGCA	0.672													0	0	0	1	0	45	3										A	18088053	G	A	18088053	3	1	101	1	0	0	0	0	1	0	0	0	530	1059	37	1	498	1	ALKBH5	17	18088053	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	7689718	18088053	63107157	120	31562										
GPR179	440435	broad.mit.edu	37	chr17	36492872	36492872	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cttccttgccttgttccggcGgcagcggtaggagaccagca	13	13	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:36492872G>A	uc002hpz.2	-	4	1237	c.1216C>T	c.(1216-1218)CGC>TGC	p.R406C		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	406	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTGTTCCGGCGGCAGCGGTAG	0.577													0	0	0	1	0	9	11										A	36492872	G	A	36492872	3	1	101	1	0	0	0	0	1	0	0	0	6674	1116	39	2	5919	2	GPR179	17	36492872	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	18404819	36492872	44702338	121	31563										
GSDMA	284110	broad.mit.edu	37	chr17	38133155	38133155	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctgctctcctcccttggggaCgaggagctgaccctcacgga	12	15	2	1	rs138595723	by1000genomes	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:38133155C>T	uc002htl.1	+	12	1300	c.1182C>T	c.(1180-1182)GAC>GAT	p.D394D	GSDMA_uc002htm.1_Silent_p.D394D	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	394					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						CCCTTGGGGACGAGGAGCTGA	0.597													0	0	0	1	0	24	104										T	38133155	C	T	38133155	2	4	101	1	0	0	0	0	0	0	0	1	6816	535	19	2		2	GSDMA	17	38133155	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	1640283	38133155	43062055	122	31564										
PTRF	284119	broad.mit.edu	37	chr17	40556892	40556892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gcacttccacctggccctcgCggatcttcttgacgtggaag	11	14	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:40556892C>T	uc002hzo.2	-	2	1145	c.986G>A	c.(985-987)CGC>CAC	p.R329H	PTRF_uc010wgi.1_Missense_Mutation_p.R311H	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	329					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CTGGCCCTCGCGGATCTTCTT	0.677													0	0	0	1	0	24	66										T	40556892	C	T	40556892	3	4	101	1	0	0	0	0	1	0	0	0	12815	768	27	2	190	2	PTRF	17	40556892	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	2423737	40556892	40638318	123	31565										
CDC27	996	broad.mit.edu	37	chr17	45247383	45247383	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cttattaaacactccaccagAtaagatttgttccccttctg	4	12	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:45247383A>C	uc002ild.3	-	4	404	c.277T>G	c.(277-279)TCT>GCT	p.S93A	CDC27_uc002ile.3_Missense_Mutation_p.S93A|CDC27_uc002ilf.3_Missense_Mutation_p.S93A|CDC27_uc010wkp.1_Missense_Mutation_p.S32A|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	93	TPR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						ACTCCACCAGATAAGATTTGT	0.313													0	0	0	1	0	8	142										C	45247383	A	C	45247383	3	2	101	1	0	0	0	0	1	0	0	0	3066	333	12	5	2279	5	CDC27	17	45247383	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	4690491	45247383	35947827	124	31566										
CDK5RAP3	80279	broad.mit.edu	37	chr17	46053301	46053301	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggaaactcaacggtgtacgaGtggaggacagggacagagcc	16	8	1	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:46053301G>A	uc002imr.2	+	8	804	c.720G>A	c.(718-720)GAG>GAA	p.E240E	CDK5RAP3_uc010wlc.1_Silent_p.E260E|CDK5RAP3_uc002imq.1_Silent_p.E15E|CDK5RAP3_uc002imu.2_Silent_p.E84E|CDK5RAP3_uc002ims.2_Silent_p.E153E|CDK5RAP3_uc002imv.2_Silent_p.E84E|CDK5RAP3_uc002imw.2_Silent_p.E84E|CDK5RAP3_uc002imx.2_Silent_p.E15E	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	240					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						CGGTGTACGAGTGGAGGACAG	0.587													0	0	0	1	0	46	84										A	46053301	G	A	46053301	2	1	101	1	0	0	0	0	0	0	0	1	3147	1020	36	2		2	CDK5RAP3	17	46053301	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	805918	46053301	35141909	125	31567										
TRIM25	7706	broad.mit.edu	37	chr17	54969173	54969173	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acatcaggtggaccttgtcgGcaacagcgaagaagatgaca	12	9	1	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:54969173G>T	uc002iut.2	-	9	1841	c.1781C>A	c.(1780-1782)GCC>GAC	p.A594D	TRIM25_uc010dcj.2_Missense_Mutation_p.A386D	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	594	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GACCTTGTCGGCAACAGCGAA	0.542													1	0	4.4004e-07	1	4.45217e-07	25	28										T	54969173	G	T	54969173	3	4	101	1	0	0	0	0	1	0	0	0	16496	1203	42	4	115	4	TRIM25	17	54969173	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	8915872	54969173	26226037	126	31568										
LPO	4025	broad.mit.edu	37	chr17	56321382	56321382	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	taccagaacctctgccatctCcgatactgtgagtcaggcca	8	14	3	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:56321382C>G	uc002ivt.2	+	3	420	c.104C>G	c.(103-105)TCC>TGC	p.S35C	LPO_uc010dco.2_Missense_Mutation_p.S35C|LPO_uc010wnr.1_Intron|LPO_uc010wns.1_Intron|LPO_uc010dcp.2_Intron	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	35					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						TCTGCCATCTCCGATACTGTG	0.468													0	0	0	1	0	11	32										G	56321382	C	G	56321382	3	3	101	1	0	0	0	0	1	0	0	0	8922	855	30	1	110	1	LPO	17	56321382	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	1352209	56321382	24873828	127	31569										
LPO	4025	broad.mit.edu	37	chr17	56342246	56342246	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggtcccctctagtatgttccGcctggatgagaattatcagc	10	11	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:56342246G>A	uc002ivt.2	+	10	1746	c.1430G>A	c.(1429-1431)CGC>CAC	p.R477H	LPO_uc010wns.1_Missense_Mutation_p.R418H|LPO_uc010dcp.2_Missense_Mutation_p.R394H|LPO_uc010dcq.2_Missense_Mutation_p.R148H|LPO_uc010dcr.2_Missense_Mutation_p.R40H	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	477					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						AGTATGTTCCGCCTGGATGAG	0.512													0	0	0	1	0	32	43										A	56342246	G	A	56342246	3	1	101	1	0	0	0	0	1	0	0	0	8922	1087	38	2	1464	2	LPO	17	56342246	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	20864	56342246	24852964	128	31570										
GPR142	350383	broad.mit.edu	37	chr17	72368159	72368159	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cctgcaccatcgggccgcctCgtccccaggccggacccgcc	11	22	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:72368159C>T	uc010wqy.1	+	4	809	c.809C>T	c.(808-810)TCG>TTG	p.S270L	GPR142_uc010wqx.1_Missense_Mutation_p.S182L	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	270	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CGGGCCGCCTCGTCCCCAGGC	0.657													0	0	0	1	0	23	22										T	72368159	C	T	72368159	3	4	101	1	0	0	0	0	1	0	0	0	6650	893	31	1	823	1	GPR142	17	72368159	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	16025913	72368159	8827051	129	31571										
PRTN3	5657	broad.mit.edu	37	chr19	846267	846267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggggccgcgtgggtgcccacGaccccccagcccaggtcctg	15	18	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:846267G>A	uc002lqa.1	+	4	514	c.490G>A	c.(490-492)GAC>AAC	p.D164N		NM_002777	NP_002768	P24158	PRTN3_HUMAN	myeloblastin	164	Peptidase S1.				collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTGCCCACGACCCCCCAGC	0.677													0	0	0	1	0	8	8										A	846267	G	A	846267	3	1	101	1	0	0	0	0	1	0	0	0	12639	1058	37	1	504	1	PRTN3	19	846267	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		846267	58282716	130	31572										
PTPRS	5802	broad.mit.edu	37	chr19	5212395	5212395	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tctggcgggttgcaggtcttGactctccgcaggaaagccag	14	11	3	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:5212395G>A	uc002mbv.2	-	31	4956	c.4722C>T	c.(4720-4722)GTC>GTT	p.V1574V	PTPRS_uc002mbu.1_Silent_p.V1143V|PTPRS_uc010xin.1_Silent_p.V1116V|PTPRS_uc002mbw.2_Silent_p.V1536V|PTPRS_uc002mbx.2_Silent_p.V1131V|PTPRS_uc002mby.2_Silent_p.V1127V	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1574	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TGCAGGTCTTGACTCTCCGCA	0.662													0	0	0	1	0	6	27										A	5212395	G	A	5212395	2	1	101	1	0	0	0	0	0	0	0	1	12811	1277	45	1		1	PTPRS	19	5212395	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	4366128	5212395	53916588	131	31573										
MUC16	94025	broad.mit.edu	37	chr19	9076790	9076790	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	acttctgggttgggtgtggtAgttgagattgagttggttcc	16	4	1	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:9076790A>T	uc002mkp.2	-	3	10860	c.10656T>A	c.(10654-10656)ACT>ACA	p.T3552T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3553	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGTGTGGTAGTTGAGATTG	0.547													0	0	0	1	0	90	131										T	9076790	A	T	9076790	2	4	101	1	0	0	0	0	0	0	0	1	9973	407	15	5		5	MUC16	19	9076790	Silent	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	3864395	9076790	50052193	132	31574										
CACNA1A	773	broad.mit.edu	37	chr19	13409644	13409644	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctccctgctgcccccctgccGgtgcacgtgcctccggtggg	13	19	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:13409644G>A	uc010dze.2	-	19	3042	c.2806C>T	c.(2806-2808)CGG>TGG	p.R936W	CACNA1A_uc010dzc.2_Missense_Mutation_p.R461W|CACNA1A_uc002mwy.3_Missense_Mutation_p.R935W|CACNA1A_uc010xne.1_Missense_Mutation_p.R464W	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	936	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCCCCCTGCCGGTGCACGTGC	0.731													0	0	0	1	0	16	20										A	13409644	G	A	13409644	3	1	101	1	0	0	0	0	1	0	0	0	2538	1115	39	2	4935	2	CACNA1A	19	13409644	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	4332854	13409644	45719339	133	31575										
ZNF257	113835	broad.mit.edu	37	chr19	22272043	22272043	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gaatgtggcaaagcctttaaCcggtcttcacacctttctca	7	12	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:22272043C>T	uc010ecx.2	+	4	1660	c.1491C>T	c.(1489-1491)AAC>AAT	p.N497N	ZNF257_uc010ecy.2_Silent_p.N465N	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	497	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAGCCTTTAACCGGTCTTCAC	0.393													0	0	0	1	0	32	35										T	22272043	C	T	22272043	2	4	101	1	0	0	0	0	0	0	0	1	17797	506	18	2		2	ZNF257	19	22272043	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	8862399	22272043	36856940	134	31576										
ZNF792	126375	broad.mit.edu	37	chr19	35451871	35451871	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctcctcctgggagaagtaaaTggtcacgtcctcaaaggtca	10	11	3	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:35451871T>C	uc002nxh.1	-	2	448	c.61A>G	c.(61-63)ATT>GTT	p.I21V		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAGAAGTAAATGGTCACGTCC	0.547													0	0	0	1	0	76	102										C	35451871	T	C	35451871	3	2	101	1	0	0	0	0	1	0	0	0	18161	1464	51	5	1849	5	ZNF792	19	35451871	Missense_Mutation	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08	13179828	35451871	23677112	135	31577										
HPN	3249	broad.mit.edu	37	chr19	35551678	35551678	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	aacagcgaggagaacagcaaCgatattgccctggtccacct	10	12	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:35551678C>T	uc002nxq.1	+	10	1013	c.768C>T	c.(766-768)AAC>AAT	p.N256N	HPN_uc002nxr.1_Silent_p.N256N|HPN_uc002nxs.1_Silent_p.N98N|HPN_uc010xsh.1_Silent_p.N225N|HPN_uc002nxt.1_Silent_p.N140N|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	256	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	AGAACAGCAACGATATTGCCC	0.637													0	0	0	1	0	19	105										T	35551678	C	T	35551678	2	4	101	1	0	0	0	0	0	0	0	1	7336	535	19	2		2	HPN	19	35551678	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	99807	35551678	23577305	136	31578										
TIMM50	92609	broad.mit.edu	37	chr19	39971574	39971574	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggactgtgcacgaggttggcGacgccgccccgccgggcccc	16	17	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:39971574G>A	uc002olu.1	+	1	523	c.390G>A	c.(388-390)GCG>GCA	p.A130A	TIMM50_uc002olt.1_RNA	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	27					mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGAGGTTGGCGACGCCGCCCC	0.706													0	0	0	1	0	9	23										A	39971574	G	A	39971574	2	1	101	1	0	0	0	0	0	0	0	1	15910	1045	37	1		1	TIMM50	19	39971574	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	4419896	39971574	19157409	137	31579										
MARK4	57787	broad.mit.edu	37	chr19	45783636	45783636	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	catccccccctcccagaggtGatggtgggtatgggctacac	12	14	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:45783636G>A	uc002pbb.1	+	11	1016	c.1011G>A	c.(1009-1011)GTG>GTA	p.V337V	MARK4_uc002paz.1_Missense_Mutation_p.D75N|MARK4_uc002pba.1_Silent_p.V337V|MARK4_uc002pbc.1_Silent_p.V203V			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	337	UBA.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCCCAGAGGTGATGGTGGGTA	0.428													0	0	0	1	0	115	148										A	45783636	G	A	45783636	2	1	101	1	0	0	0	0	0	0	0	1	9315	1277	45	1		1	MARK4	19	45783636	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	5812062	45783636	13345347	138	31580										
ZNF649	65251	broad.mit.edu	37	chr19	52394437	52394437	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tccacattcactgcatgtatGaggcttctctcctgtatgag	8	11	2	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:52394437G>C	uc002pxy.2	-	5	1220	c.952C>G	c.(952-954)CAT>GAT	p.H318D	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	318	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTGCATGTATGAGGCTTCTCT	0.453													0	0	0	1	0	27	37										C	52394437	G	C	52394437	3	2	101	1	0	0	0	0	1	0	0	0	18061	1290	45	1	569	1	ZNF649	19	52394437	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	6610801	52394437	6734546	139	31581										
BRSK1	84446	broad.mit.edu	37	chr19	55815073	55815073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tggattctcccatgctgagcCgtcacgggaagcggcgacca	13	13	2	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:55815073C>T	uc002qkg.2	+	12	1442	c.1165C>T	c.(1165-1167)CGT>TGT	p.R389C	BRSK1_uc002qkf.2_Missense_Mutation_p.R405C|BRSK1_uc002qkh.2_Missense_Mutation_p.R84C	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	389					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CATGCTGAGCCGTCACGGGAA	0.582													0	0	0	1	0	61	82										T	55815073	C	T	55815073	3	4	101	1	0	0	0	0	1	0	0	0	1523	652	23	2	1211	2	BRSK1	19	55815073	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	3420636	55815073	3313910	140	31582										
SERINC3	10955	broad.mit.edu	37	chr20	43142655	43142655	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	cagcaactacacagcaaacaTgaggcaccgctgcagaggca	10	13	0	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr20:43142655T>C	uc002xme.2	-	2	200	c.66A>G	c.(64-66)TCA>TCG	p.S22S	SERINC3_uc002xmf.1_Silent_p.S22S|SERINC3_uc010ggs.1_Silent_p.S15S|SERINC3_uc010zwp.1_5'UTR	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	22	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			ACAGCAAACATGAGGCACCGC	0.488													0	0	0	1	0	84	49										C	43142655	T	C	43142655	2	2	101	1	0	0	0	0	0	0	0	1	14081	1451	51	5		5	SERINC3	20	43142655	Silent	SNP	T	TCGA-GC-A3BM-01A-11D-A22Z-08		43142655	19882865	141	31583										
LAMA5	3911	broad.mit.edu	37	chr20	60913289	60913289	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gtggagaggcaccactcacaCtggcagagagggaagtgaaa	15	8	1	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr20:60913289C>T	uc002ycq.2	-	13	1822	c.1755G>A	c.(1753-1755)CAG>CAA	p.Q585Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	585	Laminin EGF-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCACTCACACTGGCAGAGAG	0.672													0	0	0	1	0	18	23										T	60913289	C	T	60913289	2	4	101	1	0	0	0	0	0	0	0	1	8609	579	20	2		2	LAMA5	20	60913289	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	17770634	60913289	2112231	142	31584										
RIPK4	54101	broad.mit.edu	37	chr21	43176836	43176836	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	atggcaatggctccgaagccAgcagcttttccagggagccc	12	13	0	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr21:43176836A>C	uc002yzn.1	-	2	371	c.323T>G	c.(322-324)CTG>CGG	p.L108R		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	108						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CTCCGAAGCCAGCAGCTTTTC	0.602													0	0	0	1	0	49	50										C	43176836	A	C	43176836	3	2	101	1	0	0	0	0	1	0	0	0	13383	188	7	5	2059	5	RIPK4	21	43176836	Missense_Mutation	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08		43176836	4953059	143	31585										
PCBP3	54039	broad.mit.edu	37	chr21	47349884	47349884	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	caaaccccctttcctcccctCggacagaccaaccccgcttt	4	21	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr21:47349884C>G	uc002zhq.1	+	10	896	c.771C>G	c.(769-771)CTC>CTG	p.L257L	PCBP3_uc010gqb.2_Silent_p.L257L|PCBP3_uc002zhp.1_Silent_p.L257L|PCBP3_uc002zhs.1_Silent_p.L231L|PCBP3_uc002zhr.1_Silent_p.L256L|PCBP3_uc002zht.1_Silent_p.L247L	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	257					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TTCCTCCCCTCGGACAGACCA	0.552													0	0	0	1	0	60	105										G	47349884	C	G	47349884	2	3	101	1	0	0	0	0	0	0	0	1	11502	871	31	1		1	PCBP3	21	47349884	Silent	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08	4173048	47349884	780011	144	31586										
SNAP29	9342	broad.mit.edu	37	chr22	21213484	21213484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ggccccttggagggacgcccGagacctccccgacgggcccg	15	18	0	1			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:21213484G>A	uc011ahw.1	+	1	193	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	PI4KA_uc002zsz.3_5'Flank|PI4KA_uc010gsq.1_5'Flank	NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	29					cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			AGGGACGCCCGAGACCTCCCC	0.716													0	0	0	1	0	10	28										A	21213484	G	A	21213484	3	1	101	1	0	0	0	0	1	0	0	0	14831	1058	37	1	88	1	SNAP29	22	21213484	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08		21213484	30091082	145	31587										
MYH9	4627	broad.mit.edu	37	chr22	36698721	36698722	+	Frame_Shift_Del	DEL	CT	CT	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	ctgctgccgcttggcaaatgCtctgtgtggtgaggaacatg							TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:36698721_36698722delCT	uc003apg.2	-	20	2622_2623	c.2391_2392delAG	c.(2389-2394)AAAGCAfs	p.K797fs	MYH9_uc003aph.1_Frame_Shift_Del_p.K661fs	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	797_798	IQ.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTGGCAAATGCTCTGTGTGGTG	0.599			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated									39	43	---	---								-	36698722	CT	-	36698721	7	5	101	1	0	1	0	1	0	0	0	0	10042	811	28	0	3578	0	MYH9	22	36698721	Frame_Shift_Del	DEL	CT	TCGA-GC-A3BM-01A-11D-A22Z-08	15485237	36698721	14605845	146	31588										
EP300	2033	broad.mit.edu	37	chr22	41523722	41523723	+	Frame_Shift_Del	DEL	AC	AC	-													0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	agaatgtcctaaaccacatgAcacactgccagtcaggcaag							TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			AC	-	AC	AC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:41523722_41523723delAC	uc003azl.3	+	4	1533_1534	c.1138_1139delAC	c.(1138-1140)ACAfs	p.T380fs		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	380	TAZ-type 1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AAACCACATGACACACTGCCAG	0.51			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome									55	72	---	---								-	41523723	AC	-	41523722	7	5	101	1	0	1	0	1	0	0	0	0	5148	275	10	0	1152	0	EP300	22	41523722	Frame_Shift_Del	DEL	AC	TCGA-GC-A3BM-01A-11D-A22Z-08	4825001	41523722	9780844	147	31589										
ZCCHC5	203430	broad.mit.edu	37	chrX	77912861	77912861	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	gatccagagagtgctttcatCccagttcagctcttgagcaa	9	11	3	2			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:77912861C>T	uc004edc.1	-	2	1353	c.1057G>A	c.(1057-1059)GAT>AAT	p.D353N		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	353							nucleic acid binding|zinc ion binding			ovary(1)	1						GTGCTTTCATCCCAGTTCAGC	0.473													0	0	0	1	0	20	3										T	77912861	C	T	77912861	3	4	101	1	0	0	0	0	1	0	0	0	17588	855	30	1	374	1	ZCCHC5	23	77912861	Missense_Mutation	SNP	C	TCGA-GC-A3BM-01A-11D-A22Z-08		77912861	77357699	148	31590										
PABPC5	140886	broad.mit.edu	37	chrX	90691635	90691635	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgcttttcctcttttgaagaGgctaccaaagcagtggatga	10	8	1	3			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:90691635G>A	uc004efg.2	+	2	1499	c.1059G>A	c.(1057-1059)GAG>GAA	p.E353E	PABPC5_uc004eff.1_Silent_p.E189E	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	353	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CTTTTGAAGAGGCTACCAAAG	0.517													0	0	0	1	0	29	2										A	90691635	G	A	90691635	2	1	101	1	0	0	0	0	0	0	0	1	11367	991	35	2		2	PABPC5	23	90691635	Silent	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	12778774	90691635	64578925	149	31591										
RGAG1	57529	broad.mit.edu	37	chrX	109697193	109697193	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	attaacatcacagcctctggAtcaaagcccacatcgcacat	5	14	3	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:109697193A>G	uc004eor.1	+	3	3594	c.3348A>G	c.(3346-3348)GGA>GGG	p.G1116G	RGAG1_uc011msr.1_Silent_p.G1116G	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1116										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CAGCCTCTGGATCAAAGCCCA	0.527													0	0	0	1	0	110	8										G	109697193	A	G	109697193	2	3	101	1	0	0	0	0	0	0	0	1	13274	320	12	5		5	RGAG1	23	109697193	Silent	SNP	A	TCGA-GC-A3BM-01A-11D-A22Z-08	19005558	109697193	45573367	150	31592										
HTR2C	3358	broad.mit.edu	37	chrX	114141244	114141244	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.245033112582781	37	1.14061053657445e-06	2.31287089013633	5.43837209302326	1.66172480620155	0.173309527689083	0.321849597646462	21	tgctcaacgacccaaatttcGttcttattgggtccttcgta	7	11	2	0			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:114141244G>A	uc004epu.1	+	6	1371	c.643G>A	c.(643-645)GTT>ATT	p.V215I	HTR2C_uc010nqc.1_Missense_Mutation_p.V215I|HTR2C_uc004epv.1_Missense_Mutation_p.R183H	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	215	Helical; Name=5; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CCCAAATTTCGTTCTTATTGG	0.468													0	0	0	1	0	191	15										A	114141244	G	A	114141244	3	1	101	1	0	0	0	0	1	0	0	0	7443	1145	40	2	657	2	HTR2C	23	114141244	Missense_Mutation	SNP	G	TCGA-GC-A3BM-01A-11D-A22Z-08	4444051	114141244	41129316	151	31593										
CLCNKB	1188	broad.mit.edu	37	chr1	16375654	16375654	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggtcatgtcttcccacttctCtgtctgggattactggaggg	12	10	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:16375654C>G	uc001axw.3	+	8	775	c.695C>G	c.(694-696)TCT>TGT	p.S232C	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Missense_Mutation_p.S232C|CLCNKB_uc001axy.3_Missense_Mutation_p.S63C	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	232					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCACTTCTCTGTCTGGGAT	0.637													0	0	0	0.134883	0	27	66										G	16375654	C	G	16375654	3	3	102	1	0	0	0	0	1	0	0	0	3470	913	32	1	869	1	CLCNKB	1	16375654	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		16375654	232874967	1	31594										
ALDH4A1	8659	broad.mit.edu	37	chr1	19204070	19204070	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccacgctctccacgtcggccGagcggtgcacgaagtggaag	14	14	1	0	rs139430775		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:19204070G>A	uc001bbb.2	-	10	1253	c.977C>T	c.(976-978)TCG>TTG	p.S326L	ALDH4A1_uc010ocu.1_Missense_Mutation_p.S266L|ALDH4A1_uc001bbc.2_Missense_Mutation_p.S326L	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	326					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	CACGTCGGCCGAGCGGTGCAC	0.672													0	0	0	0.009096	0	3	19										A	19204070	G	A	19204070	3	1	102	1	0	0	0	0	1	0	0	0	501	1059	37	1	738	1	ALDH4A1	1	19204070	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	2828416	19204070	230046551	2	31595										
GRHL3	57822	broad.mit.edu	37	chr1	24664503	24664503	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtgtggtgatggttgtcttcGacaatgagaaggtcccagta	14	6	1	2	rs141594535		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:24664503G>A	uc001biy.2	+	7	923	c.877G>A	c.(877-879)GAC>AAC	p.D293N	GRHL3_uc001bix.2_Missense_Mutation_p.D288N|GRHL3_uc001biz.2_Missense_Mutation_p.D195N	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	288					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		GGTTGTCTTCGACAATGAGAA	0.572													0	0	0	0.117977	0	35	69										A	24664503	G	A	24664503	3	1	102	1	0	0	0	0	1	0	0	0	6765	1058	37	1	924	1	GRHL3	1	24664503	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	5460433	24664503	224586118	3	31596										
GPN2	54707	broad.mit.edu	37	chr1	27216470	27216470	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtccaggttcaccaccgccaCgcgccggcccagcgcgcgca	12	20	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:27216470C>T	uc001bnd.1	-	1	400	c.118G>A	c.(118-120)GTG>ATG	p.V40M		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	40							GTP binding				0						ACCACCGCCACGCGCCGGCCC	0.721													0	0	0	0.009096	0	3	12										T	27216470	C	T	27216470	3	4	102	1	0	0	0	0	1	0	0	0	6618	536	19	2	834	2	GPN2	1	27216470	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2551967	27216470	222034151	4	31597										
CSMD2	114784	broad.mit.edu	37	chr1	34208906	34208906	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaagtgatgttgaagcccctCttccctgtggagtggtcagt	12	9	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:34208906C>T	uc001bxn.1	-	14	2057	c.2028G>A	c.(2026-2028)AAG>AAA	p.K676K	CSMD2_uc001bxm.1_Silent_p.K716K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	676	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAAGCCCCTCTTCCCTGTGG	0.582													0	0	0	0.02938	0	5	20										T	34208906	C	T	34208906	2	4	102	1	0	0	0	0	0	0	0	1	3945	912	32	1		1	CSMD2	1	34208906	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	6992436	34208906	215041715	5	31598										
MTF1	4520	broad.mit.edu	37	chr1	38289456	38289456	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	attcaaagatgattgctggtGaaattgtgctgaggtcctgg	13	5	1	4			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:38289456G>A	uc001cce.1	-	8	1238	c.1097C>T	c.(1096-1098)TCA>TTA	p.S366L	MTF1_uc009vvj.1_Missense_Mutation_p.S57L	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	366						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GATTGCTGGTGAAATTGTGCT	0.438													0	0	0	0.069288	0	18	34										A	38289456	G	A	38289456	3	1	102	1	0	0	0	0	1	0	0	0	9922	1294	45	1	1180	1	MTF1	1	38289456	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	4080550	38289456	210961165	6	31599										
RHBDL2	54933	broad.mit.edu	37	chr1	39384795	39384795	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttacctcccccatcctctctCattttctcctcttcctccag	1	20	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:39384795C>T	uc001ccu.1	-	2	318	c.90G>A	c.(88-90)ATG>ATA	p.M30I	RHBDL2_uc010oin.1_Missense_Mutation_p.M30I|RHBDL2_uc010oio.1_Missense_Mutation_p.M110I|RHBDL2_uc001ccv.2_Missense_Mutation_p.M30I	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	30					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CATCCTCTCTCATTTTCTCCT	0.488													0	0	0	0.134883	0	27	91										T	39384795	C	T	39384795	3	4	102	1	0	0	0	0	1	0	0	0	13322	826	29	1	849	1	RHBDL2	1	39384795	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1095339	39384795	209865826	7	31600										
CYP4A22	284541	broad.mit.edu	37	chr1	47603168	47603168	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtgctgcaccatgagtgtctCtgtcctgagccccagcagac	11	14	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:47603168C>G	uc001cqv.1	+	1	62	c.11C>G	c.(10-12)TCT>TGT	p.S4C	CYP4A22_uc009vyo.2_Missense_Mutation_p.S4C|CYP4A22_uc009vyp.2_Missense_Mutation_p.S4C	NM_001010969	NP_001010969	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A,	4						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			skin(2)|ovary(1)|breast(1)	4						ATGAGTGTCTCTGTCCTGAGC	0.597													0	0	0	0.125774	0	28	70										G	47603168	C	G	47603168	3	3	102	1	0	0	0	0	1	0	0	0	4184	913	32	1	13	1	CYP4A22	1	47603168	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	8218373	47603168	201647453	8	31601										
LRRC7	57554	broad.mit.edu	37	chr1	70504238	70504238	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccactaccagcccattgcctGaaaggaaagaacatataaag	7	11	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:70504238G>A	uc001dep.2	+	19	2647	c.2617G>A	c.(2617-2619)GAA>AAA	p.E873K	LRRC7_uc009wbg.2_Missense_Mutation_p.E157K|LRRC7_uc001deq.2_Missense_Mutation_p.E114K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	873						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCCATTGCCTGAAAGGAAAGA	0.458													0	0	0	0.139131	0	35	63										A	70504238	G	A	70504238	3	1	102	1	0	0	0	0	1	0	0	0	9020	1291	45	1	2691	1	LRRC7	1	70504238	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	22901070	70504238	178746383	9	31602										
CCDC18	343099	broad.mit.edu	37	chr1	93680450	93680450	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaaggttaacatggctcacaGaactagtcagtttcagctga	10	8	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:93680450G>C	uc001dpq.2	+	12	2168	c.2000G>C	c.(1999-2001)AGA>ACA	p.R667T	CCDC18_uc009wdl.1_Missense_Mutation_p.R228T	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	548	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		ATGGCTCACAGAACTAGTCAG	0.383													0	0	0	0.058154	0	8	14										C	93680450	G	C	93680450	3	2	102	1	0	0	0	0	1	0	0	0	2794	942	33	1	2046	1	CCDC18	1	93680450	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	23176212	93680450	155570171	10	31603										
PDE4DIP	9659	broad.mit.edu	37	chr1	144879256	144879256	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tccaaggtgccaacagctctCagcttccagggtctttccag	9	14	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:144879256C>A	uc001elw.3	-	27	4485	c.4194G>T	c.(4192-4194)CTG>CTT	p.L1398L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L1354L|PDE4DIP_uc001elv.3_Silent_p.L405L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1398					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAACAGCTCTCAGCTTCCAGG	0.537			T	PDGFRB	MPD								1	0	1.00905e-13	0.049695	1.09023e-13	19	102										A	144879256	C	A	144879256	2	1	102	1	0	0	0	0	0	0	0	1	11643	813	29	3		3	PDE4DIP	1	144879256	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	51198806	144879256	104371365	11	31604										
PDE4DIP	9659	broad.mit.edu	37	chr1	144882724	144882724	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gagctttctgaactcagcctGaaggctactctcactcagac	8	13	4	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:144882724G>A	uc001elw.3	-	24	3586	c.3295C>T	c.(3295-3297)CAG>TAG	p.Q1099*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Nonsense_Mutation_p.Q106*	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1099	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AACTCAGCCTGAAGGCTACTC	0.483			T	PDGFRB	MPD								0	0	0	0.139131	0	38	208										A	144882724	G	A	144882724	4	1	102	1	0	0	0	0	0	1	0	0	11643	1299	45	1	3829	1	PDE4DIP	1	144882724	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3468	144882724	104367897	12	31605										
RPRD2	23248	broad.mit.edu	37	chr1	150444774	150444774	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agttcctgggaagggaaataGaggacatgggcgtgaggctt	17	5	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:150444774G>A	uc009wlr.2	+	11	3551	c.3350G>A	c.(3349-3351)AGA>AAA	p.R1117K	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.R1091K	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1117							protein binding			ovary(1)	1						AAGGGAAATAGAGGACATGGG	0.522													0	0	0	0.038147	0	6	19										A	150444774	G	A	150444774	3	1	102	1	0	0	0	0	1	0	0	0	13617	942	33	1	3392	1	RPRD2	1	150444774	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	5562050	150444774	98805847	13	31606										
HORMAD1	84072	broad.mit.edu	37	chr1	150679139	150679139	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgagtcaatattttccattcGttctctctcagtggtcactt	6	10	4	1	rs150156011		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:150679139G>A	uc001evk.1	-	10	800	c.694C>T	c.(694-696)CGA>TGA	p.R232*	HORMAD1_uc001evl.1_Nonsense_Mutation_p.R225*|HORMAD1_uc001evm.1_Nonsense_Mutation_p.R152*	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	232					blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTTTCCATTCGTTCTCTCTCA	0.353													0	0	0	0.076483	0	18	64										A	150679139	G	A	150679139	4	1	102	1	0	0	0	0	0	1	0	0	7286	1153	40	2	514	2	HORMAD1	1	150679139	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	234365	150679139	98571482	14	31607										
CELF3	11189	broad.mit.edu	37	chr1	151678328	151678328	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gctttgattggtggctcggtCaacaaagactttggctgaga	13	7	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:151678328C>T	uc001eys.1	-	11	2034	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	CELF3_uc010pdh.1_Missense_Mutation_p.D200N|CELF3_uc001eyr.2_Missense_Mutation_p.D413N|CELF3_uc009wmy.2_Missense_Mutation_p.D364N|CELF3_uc009wmx.1_Missense_Mutation_p.D413N	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	414	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						GTGGCTCGGTCAACAAAGACT	0.438													0	0	0	0.132662	0	13	30										T	151678328	C	T	151678328	3	4	102	1	0	0	0	0	1	0	0	0	3217	826	29	1	165	1	CELF3	1	151678328	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	999189	151678328	97572293	15	31608										
TCHH	7062	broad.mit.edu	37	chr1	152080269	152080269	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgggggcgcagctgctgttcTtccctctcctggcgtagctg	14	13	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:152080269T>C	uc001ezp.2	-	2	5424	c.5424A>G	c.(5422-5424)GAA>GAG	p.E1808E	TCHH_uc009wne.1_Silent_p.E1808E	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1808	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGCTGTTCTTCCCTCTCCT	0.597													0	0	0	0.009096	0	3	72										C	152080269	T	C	152080269	2	2	102	1	0	0	0	0	0	0	0	1	15697	1606	56	5		5	TCHH	1	152080269	Silent	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	401941	152080269	97170352	16	31609										
IL6R	3570	broad.mit.edu	37	chr1	154420627	154420627	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggagtcctccagctgagaacGaggtgtccacccccatgcag	12	14	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:154420627G>A	uc001fez.1	+	7	1413	c.976G>A	c.(976-978)GAG>AAG	p.E326K	IL6R_uc001ffa.1_Missense_Mutation_p.E326K	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	326	Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCTGAGAACGAGGTGTCCAC	0.463													0	0	0	0.139131	0	38	64										A	154420627	G	A	154420627	3	1	102	1	0	0	0	0	1	0	0	0	7702	1059	37	1	1002	1	IL6R	1	154420627	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	2340358	154420627	94829994	17	31610										
RXRG	6258	broad.mit.edu	37	chr1	165398029	165398029	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctgagggtgggcccatggcaGaggtgatgactcgatatgga	17	7	0	4			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:165398029G>T	uc001gda.2	-	2	524	c.224C>A	c.(223-225)TCT>TAT	p.S75Y		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	75	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GCCCATGGCAGAGGTGATGAC	0.602													1	0	4.63292e-17	0.049695	5.06389e-17	18	28										T	165398029	G	T	165398029	3	4	102	1	0	0	0	0	1	0	0	0	13765	942	33	3	1203	3	RXRG	1	165398029	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	10977402	165398029	83852592	18	31611										
C1orf116	79098	broad.mit.edu	37	chr1	207196604	207196604	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctggctgacctgttctttctCaggctctggcgcaagcctcc	10	15	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:207196604C>T	uc001hfd.2	-	4	764	c.505G>A	c.(505-507)GAG>AAG	p.E169K	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	169						cytoplasm|plasma membrane	receptor activity	p.E169E(1)		skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					TGTTCTTTCTCAGGCTCTGGC	0.602													0	0	0	0.083992	0	25	33										T	207196604	C	T	207196604	3	4	102	1	0	0	0	0	1	0	0	0	1989	835	29	1	1304	1	C1orf116	1	207196604	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	41798575	207196604	42054017	19	31612										
ARID4B	51742	broad.mit.edu	37	chr1	235331917	235331917	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	taaagttaacataacagcagCtgttatggaactggatgaag	10	5	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:235331917C>T	uc001hwq.2	-	24	4360	c.3862G>A	c.(3862-3864)GCT>ACT	p.A1288T	ARID4B_uc001hwr.2_Missense_Mutation_p.A1202T|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1288	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ATAACAGCAGCTGTTATGGAA	0.428													0	0	0	0.146539	0	14	28										T	235331917	C	T	235331917	3	4	102	1	0	0	0	0	1	0	0	0	920	797	28	2	80	2	ARID4B	1	235331917	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	28135313	235331917	13918704	20	31613										
ZNF695	57116	broad.mit.edu	37	chr1	247151490	247151490	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctttcatatcttctcagcatCactttttggaatgaaacttg	5	9	4	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr1:247151490C>T	uc009xgu.2	-	4	472	c.327G>A	c.(325-327)GTG>GTA	p.V109V	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Silent_p.V109V|ZNF695_uc001iby.2_Intron|ZNF695_uc001icc.2_Silent_p.V97V	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	109					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TTCTCAGCATCACTTTTTGGA	0.373													0	0	0	0.0918	0	27	54										T	247151490	C	T	247151490	2	4	102	1	0	0	0	0	0	0	0	1	18095	813	29	1		1	ZNF695	1	247151490	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	11819573	247151490	2099131	21	31614										
NTSR2	23620	broad.mit.edu	37	chr2	11802346	11802346	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gttagtgccaaggggagcacGaaggacaccagcacattcac	12	11	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:11802346G>A	uc002rbq.3	-	2	719	c.645C>T	c.(643-645)TTC>TTT	p.F215F		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	215	Extracellular (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AGGGGAGCACGAAGGACACCA	0.642													0	0	0	0.058154	0	8	141										A	11802346	G	A	11802346	2	1	102	1	0	0	0	0	0	0	0	1	10711	1049	37	1		1	NTSR2	2	11802346	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		11802346	231397027	22	31615										
CAPN13	92291	broad.mit.edu	37	chr2	30976054	30976054	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaatttctgttggaaatcttGacacgacatcctgttaaaaa	7	7	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:30976054G>C	uc002rnn.2	-	10	1128	c.952C>G	c.(952-954)CAA>GAA	p.Q318E	CAPN13_uc002rnp.1_Missense_Mutation_p.Q318E	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	318	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TGGAAATCTTGACACGACATC	0.453													0	0	0	0.099896	0	21	45										C	30976054	G	C	30976054	3	2	102	1	0	0	0	0	1	0	0	0	2626	1299	45	1	1109	1	CAPN13	2	30976054	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	19173708	30976054	212223319	23	31616										
PRKD3	23683	broad.mit.edu	37	chr2	37481367	37481367	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctgtagccagggatgactaaGagatttgtcaacactgtaac	10	8	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:37481367G>A	uc002rqd.2	-	17	3034	c.2479C>T	c.(2479-2481)CTT>TTT	p.L827F		NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	827	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GGATGACTAAGAGATTTGTCA	0.368													0	0	0	0.108266	0	23	30										A	37481367	G	A	37481367	3	1	102	1	0	0	0	0	1	0	0	0	12520	942	33	1	201	1	PRKD3	2	37481367	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	6505313	37481367	205718006	24	31617										
THUMPD2	80745	broad.mit.edu	37	chr2	39964112	39964112	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgactgtccttggaattgaaAgggatgttgctctctttaca	10	7	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:39964112A>T	uc002rru.2	-	10	1312	c.1275T>A	c.(1273-1275)CCT>CCA	p.P425P	THUMPD2_uc002rrv.2_RNA|THUMPD2_uc010ynt.1_Silent_p.P316P	NM_025264	NP_079540	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	425							methyltransferase activity			skin(1)	1		all_hematologic(82;0.248)				TGGAATTGAAAGGGATGTTGC	0.418													0	0	0	0.059317	0	36	62										T	39964112	A	T	39964112	2	4	102	1	0	0	0	0	0	0	0	1	15880	59	3	5		5	THUMPD2	2	39964112	Silent	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	2482745	39964112	203235261	25	31618										
SPTBN1	6711	broad.mit.edu	37	chr2	54895611	54895611	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agaccctccccaccagcgtcGtcaccatcaccagcgagtcc	7	20	2	1	rs150630405	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:54895611G>C	uc002rxu.2	+	36	7249	c.7000G>C	c.(7000-7002)GTC>CTC	p.V2334L	SPTBN1_uc010you.1_Missense_Mutation_p.V324L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	2334					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CACCAGCGTCGTCACCATCAC	0.567													0	0	0	0.054565	0	24	28										C	54895611	G	C	54895611	3	2	102	1	0	0	0	0	1	0	0	0	15118	1145	40	4	7338	4	SPTBN1	2	54895611	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	14931499	54895611	188303762	26	31619										
CD207	50489	broad.mit.edu	37	chr2	71060100	71060100	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagaactgctcggcactataCcaggtctttggaatgagaga	11	9	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:71060100C>T	uc002shg.2	-	4	695	c.648G>A	c.(646-648)TGG>TGA	p.W216*		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	216	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						CGGCACTATACCAGGTCTTTG	0.478													0	0	0	0.146539	0	15	36										T	71060100	C	T	71060100	4	4	102	1	0	0	0	0	0	1	0	0	2983	508	18	2	350	2	CD207	2	71060100	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	16164489	71060100	172139273	27	31620										
MOGS	7841	broad.mit.edu	37	chr2	74691751	74691751	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cccgaaggagaggccgtcgtGgaactcccagccatagggac	14	13	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:74691751G>A	uc010ffj.2	-	2	614	c.451C>T	c.(451-453)CAC>TAC	p.H151Y	MOGS_uc010ffh.2_5'Flank|MOGS_uc010yrt.1_Missense_Mutation_p.H32Y|MOGS_uc010ffi.2_Missense_Mutation_p.H45Y|MOGS_uc010yru.1_Intron	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	151	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AGGCCGTCGTGGAACTCCCAG	0.652													0	0	0	0.09836	0	33	55										A	74691751	G	A	74691751	3	1	102	1	0	0	0	0	1	0	0	0	9697	1348	47	2	2074	2	MOGS	2	74691751	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3631651	74691751	168507622	28	31621										
C2orf65	130951	broad.mit.edu	37	chr2	74842183	74842183	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atcctctactgccagccgcaGagaagcaccttgtgatctga	9	13	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:74842183G>A	uc002smy.2	-	3	451	c.334C>T	c.(334-336)CTG>TTG	p.L112L	C2orf65_uc010ysa.1_Silent_p.L112L|C2orf65_uc002smz.2_Silent_p.L112L	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	112					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						GCCAGCCGCAGAGAAGCACCT	0.507													0	0	0	0.104719	0	32	87										A	74842183	G	A	74842183	2	1	102	1	0	0	0	0	0	0	0	1	2184	933	33	1		1	C2orf65	2	74842183	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	150432	74842183	168357190	29	31622										
LYG2	254773	broad.mit.edu	37	chr2	99861855	99861855	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtctctgcccgacttctttgAtcagagtctggtaaggtttt	10	9	4	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:99861855A>T	uc002szw.1	-	4	364	c.251T>A	c.(250-252)ATC>AAC	p.I84N	MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_Missense_Mutation_p.I84N|LYG2_uc002szx.1_Missense_Mutation_p.I84N	NM_175735	NP_783862	Q86SG7	LYG2_HUMAN	lysozyme G-like 2 precursor	84					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1						GACTTCTTTGATCAGAGTCTG	0.483													0	0	0	0.146539	0	14	44										T	99861855	A	T	99861855	3	4	102	1	0	0	0	0	1	0	0	0	9105	333	12	5	399	5	LYG2	2	99861855	Missense_Mutation	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	25019672	99861855	143337518	30	31623										
WDR33	55339	broad.mit.edu	37	chr2	128477268	128477268	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	attcctcttggattcaatccCatcagaggtccctgagacac	7	13	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:128477268C>A	uc002tpg.1	-	16	2514	c.2331G>T	c.(2329-2331)ATG>ATT	p.M777I		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	777					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GATTCAATCCCATCAGAGGTC	0.602													1	0	0.00909568	0.009096	0.00916065	4	9										A	128477268	C	A	128477268	3	1	102	1	0	0	0	0	1	0	0	0	17284	594	21	4	1707	4	WDR33	2	128477268	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	28615413	128477268	114722105	31	31624										
TTN	7273	broad.mit.edu	37	chr2	179432361	179432361	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cttattgcaccagctgcattCtttgcaatgactctgaattc	6	11	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:179432361C>G	uc010zfg.1	-	275	71018	c.70794G>C	c.(70792-70794)AAG>AAC	p.K23598N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K17293N|TTN_uc010zfi.1_Missense_Mutation_p.K17226N|TTN_uc010zfj.1_Missense_Mutation_p.K17101N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24525							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTGCATTCTTTGCAATGA	0.388													0	0	0	0.076483	0	16	44										G	179432361	C	G	179432361	3	3	102	1	0	0	0	0	1	0	0	0	16732	912	32	1	29629	1	TTN	2	179432361	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	50955093	179432361	63767012	32	31625										
TTN	7273	broad.mit.edu	37	chr2	179497730	179497730	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cccagctgacagttatgaagGatcagaatatgcttctttcc	8	10	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:179497730G>A	uc010zfg.1	-	183	35648	c.35424C>T	c.(35422-35424)ATC>ATT	p.I11808I	TTN_uc010zfh.1_Silent_p.I5503I|TTN_uc010zfi.1_Silent_p.I5436I|TTN_uc010zfj.1_Silent_p.I5311I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12735							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTATGAAGGATCAGAATAT	0.408													0	0	0	0.069288	0	20	19										A	179497730	G	A	179497730	2	1	102	1	0	0	0	0	0	0	0	1	16732	1164	41	1		1	TTN	2	179497730	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	65369	179497730	63701643	33	31626										
TRAK2	66008	broad.mit.edu	37	chr2	202264201	202264201	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tccaattcgagcagcgagttCcagatcacgatccctctgtt	8	13	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:202264201C>T	uc002uyb.3	-	5	825	c.379G>A	c.(379-381)GAA>AAA	p.E127K	TRAK2_uc002uyc.2_Missense_Mutation_p.E127K	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	127						early endosome|plasma membrane	GABA receptor binding				0						GCAGCGAGTTCCAGATCACGA	0.413													0	0	0	0.0333	0	12	51										T	202264201	C	T	202264201	3	4	102	1	0	0	0	0	1	0	0	0	16447	864	30	1	2413	1	TRAK2	2	202264201	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	22766471	202264201	40935172	34	31627										
COL4A4	1286	broad.mit.edu	37	chr2	227924258	227924258	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tctgaccattcactcctggtGagccgggagggcctgggggc	16	12	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:227924258G>T	uc010zlt.1	-	28	2900	c.2246C>A	c.(2245-2247)TCA>TAA	p.S749*		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	749	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CACTCCTGGTGAGCCGGGAGG	0.552													1	0	2.37509e-13	0.055883	2.5564e-13	18	55										T	227924258	G	T	227924258	4	4	102	1	0	0	0	0	0	1	0	0	3693	1294	45	3	2910	3	COL4A4	2	227924258	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	25660057	227924258	15275115	35	31628										
TRIP12	9320	broad.mit.edu	37	chr2	230723895	230723895	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atctctcttctgcaccagttGattcagacccggagccactc	7	15	4	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:230723895G>C	uc002vpw.1	-	3	603	c.494C>G	c.(493-495)TCA>TGA	p.S165*	TRIP12_uc002vpx.1_Nonsense_Mutation_p.S207*|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Nonsense_Mutation_p.S165*	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	165					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGCACCAGTTGATTCAGACCC	0.502													0	0	0	0.055883	0	20	11										C	230723895	G	C	230723895	4	2	102	1	0	0	0	0	0	1	0	0	16553	1294	45	1	5640	1	TRIP12	2	230723895	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	2799637	230723895	12475478	36	31629										
SP100	6672	broad.mit.edu	37	chr2	231308897	231308897	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttcaatattttttaaggattCtcaagattcttgtagaaacc	5	6	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:231308897C>T	uc002vqt.2	+	4	416	c.275C>T	c.(274-276)TCT>TTT	p.S92F	SP100_uc002vqs.2_Missense_Mutation_p.S92F|SP100_uc002vqu.1_Missense_Mutation_p.S92F|SP100_uc010zmb.1_Missense_Mutation_p.S92F|SP100_uc002vqq.1_Missense_Mutation_p.S92F|SP100_uc002vqr.1_Missense_Mutation_p.S67F|SP100_uc010zmc.1_Missense_Mutation_p.S67F|SP100_uc002vqv.1_Missense_Mutation_p.S56F	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	92	HSR.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TTTAAGGATTCTCAAGATTCT	0.363													0	0	0	0.146539	0	14	24										T	231308897	C	T	231308897	3	4	102	1	0	0	0	0	1	0	0	0	14960	913	32	1	289	1	SP100	2	231308897	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	585002	231308897	11890476	37	31630										
KIF1A	547	broad.mit.edu	37	chr2	241710491	241710491	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acagggctgagagcgaggatGaggggctcatacccaccagg	16	10	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:241710491G>C	uc002vzy.2	-	14	1357	c.1211C>G	c.(1210-1212)TCA>TGA	p.S404*	KIF1A_uc010fzk.2_Nonsense_Mutation_p.S413*|KIF1A_uc002vzz.1_Nonsense_Mutation_p.S413*	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	404					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GAGCGAGGATGAGGGGCTCAT	0.617													0	0	0	0.132662	0	13	40										C	241710491	G	C	241710491	4	2	102	1	0	0	0	0	0	1	0	0	8283	1294	45	1	3997	1	KIF1A	2	241710491	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	10401594	241710491	1488882	38	31631										
NEU4	129807	broad.mit.edu	37	chr2	242757402	242757402	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gccacattcgctgtgggtccCggccacggcgtgcagctgcc	14	16	0	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr2:242757402C>T	uc010fzr.2	+	4	569	c.483C>T	c.(481-483)CCC>CCT	p.P161P	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Silent_p.P161P|NEU4_uc002wcn.1_Silent_p.P173P|NEU4_uc002wco.1_Silent_p.P161P|NEU4_uc002wcp.1_Silent_p.P173P	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	161						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CTGTGGGTCCCGGCCACGGCG	0.706													0	0	0	0.069234	0	9	6										T	242757402	C	T	242757402	2	4	102	1	0	0	0	0	0	0	0	1	10344	639	23	2		2	NEU4	2	242757402	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1046911	242757402	441971	39	31632										
TGFBR2	7048	broad.mit.edu	37	chr3	30713543	30713543	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agtatgcctcttggaagacaGagaaggacatcttctcagac	10	9	3	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:30713543G>A	uc003ceo.2	+	4	1250	c.868G>A	c.(868-870)GAG>AAG	p.E290K	TGFBR2_uc003cen.2_Missense_Mutation_p.E315K	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	290	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						TTGGAAGACAGAGAAGGACAT	0.483													0	0	0	0.139131	0	61	15										A	30713543	G	A	30713543	3	1	102	1	0	0	0	0	1	0	0	0	15819	943	33	1	961	1	TGFBR2	3	30713543	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		30713543	167308887	40	31633										
ULK4	54986	broad.mit.edu	37	chr3	41746766	41746766	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctatggctccatctatgttcGtttctcctgagtctacagat	7	11	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:41746766G>A	uc003ckv.3	-	26	2867	c.2666C>T	c.(2665-2667)ACG>ATG	p.T889M		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	889							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		ATCTATGTTCGTTTCTCCTGA	0.294													0	0	0	0.139131	0	40	10										A	41746766	G	A	41746766	3	1	102	1	0	0	0	0	1	0	0	0	16975	1145	40	2	1209	2	ULK4	3	41746766	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	11033223	41746766	156275664	41	31634										
LRRC2	79442	broad.mit.edu	37	chr3	46592976	46592976	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cttctccaaggcgctcttctCaagcctttccacctccttct	4	18	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:46592976C>G	uc010hji.2	-	2	470	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	LRRC2_uc003cpu.3_Missense_Mutation_p.E36Q	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	36										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		GCGCTCTTCTCAAGCCTTTCC	0.468													0	0	0	0.139131	0	54	23										G	46592976	C	G	46592976	3	3	102	1	0	0	0	0	1	0	0	0	8976	835	29	1	1041	1	LRRC2	3	46592976	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	4846210	46592976	151429454	42	31635										
ARIH2	10425	broad.mit.edu	37	chr3	49012253	49012253	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cccttctgtctcctcagtgtCccaagtgcaacatctgcatt	6	15	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:49012253C>T	uc003cvb.2	+	10	1204	c.892C>T	c.(892-894)CCC>TCC	p.P298S	ARIH2_uc003cvc.2_Missense_Mutation_p.P298S|ARIH2_uc003cvf.2_Missense_Mutation_p.P216S|ARIH2_uc010hkl.2_Missense_Mutation_p.P298S	NM_006321	NP_006312	O95376	ARI2_HUMAN	ariadne homolog 2	298	RING-type 2.				developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.P298P(1)		ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TCCTCAGTGTCCCAAGTGCAA	0.498													0	0	0	0.139131	0	42	8										T	49012253	C	T	49012253	3	4	102	1	0	0	0	0	1	0	0	0	924	855	30	1	922	1	ARIH2	3	49012253	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2419277	49012253	149010177	43	31636										
CBLB	868	broad.mit.edu	37	chr3	105377858	105377858	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggaggagggaaggcaaattCtcggaggatgctccgggcaa	17	7	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:105377858C>T	uc003dwc.2	-	19	3227	c.2905G>A	c.(2905-2907)GAA>AAA	p.E969K	CBLB_uc003dwa.2_Missense_Mutation_p.E184K|CBLB_uc011bhi.1_Missense_Mutation_p.E947K	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	969	UBA.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AAGGCAAATTCTCGGAGGATG	0.468			Mis S		AML								0	0	0	0.125774	0	30	45										T	105377858	C	T	105377858	3	4	102	1	0	0	0	0	1	0	0	0	2701	922	32	1	47	1	CBLB	3	105377858	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	56365605	105377858	92644572	44	31637										
VEPH1	79674	broad.mit.edu	37	chr3	157082155	157082155	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccagactatatcttctgataGagccaggggtattgctccct	9	11	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:157082155G>C	uc003fbj.1	-	8	1591	c.1274C>G	c.(1273-1275)TCT>TGT	p.S425C	VEPH1_uc003fbk.1_Missense_Mutation_p.S425C|VEPH1_uc010hvu.1_Missense_Mutation_p.S425C	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	425						plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCTTCTGATAGAGCCAGGGGT	0.348													0	0	0	0.080935	0	10	42										C	157082155	G	C	157082155	3	2	102	1	0	0	0	0	1	0	0	0	17151	942	33	1	1255	1	VEPH1	3	157082155	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	51704297	157082155	40940275	45	31638										
PIK3CA	5290	broad.mit.edu	37	chr3	178922324	178922324	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	caggtatctaccatggaggaGaacccttatgtgacaatgtg	11	8	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr3:178922324G>A	uc003fjk.2	+	6	1250	c.1093G>A	c.(1093-1095)GAA>AAA	p.E365K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	365	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E365K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCATGGAGGAGAACCCTTATG	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.139131	0	58	62										A	178922324	G	A	178922324	3	1	102	1	0	0	0	0	1	0	0	0	11913	943	33	1	1111	1	PIK3CA	3	178922324	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	21840169	178922324	19100106	46	31639										
HTT	3064	broad.mit.edu	37	chr4	3142363	3142363	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acgcagcctccatctcatttCtccgtcagcacaataaccag	5	16	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:3142363C>G	uc011bvq.1	+	23	3076	c.2931C>G	c.(2929-2931)TTC>TTG	p.F977L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	975					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATCTCATTTCTCCGTCAGCA	0.473													0	0	0	0.115264	0	3	62										G	3142363	C	G	3142363	3	3	102	1	0	0	0	0	1	0	0	0	7457	912	32	1	3011	1	HTT	4	3142363	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		3142363	188011913	47	31640										
WFS1	7466	broad.mit.edu	37	chr4	6302887	6302887	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acccatgcagagccctacacGcgcagggccctggccaccga	11	18	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:6302887G>A	uc003giy.2	+	8	1531	c.1365G>A	c.(1363-1365)ACG>ACA	p.T455T	WFS1_uc003gix.2_Silent_p.T455T|WFS1_uc003giz.2_Silent_p.T273T	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	455					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		AGCCCTACACGCGCAGGGCCC	0.637													0	0	0	0.116897	0	22	55										A	6302887	G	A	6302887	2	1	102	1	0	0	0	0	0	0	0	1	17357	1074	38	2		2	WFS1	4	6302887	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3160524	6302887	184851389	48	31641										
ZNF518B	85460	broad.mit.edu	37	chr4	10446215	10446215	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tacagttgaaactgccttgtGttcctctgtctggttatctt	8	9	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:10446215G>A	uc003gmn.2	-	3	2225	c.1738C>T	c.(1738-1740)CAC>TAC	p.H580Y		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	580					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACTGCCTTGTGTTCCTCTGTC	0.393													0	0	0	0.064281	0	30	47										A	10446215	G	A	10446215	3	1	102	1	0	0	0	0	1	0	0	0	17960	1377	48	2	1490	2	ZNF518B	4	10446215	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	4143328	10446215	180708061	49	31642										
N4BP2	55728	broad.mit.edu	37	chr4	40104376	40104376	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tccagggcttgatttaccagGtacaggtggggatcagaaat	13	7	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:40104376G>A	uc003guy.3	+	4	1249	c.911G>A	c.(910-912)GGT>GAT	p.G304D	N4BP2_uc010ifq.2_Missense_Mutation_p.G224D|N4BP2_uc010ifr.2_Missense_Mutation_p.G224D	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	304						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GATTTACCAGGTACAGGTGGG	0.473													0	0	0	0.108266	0	22	51										A	40104376	G	A	40104376	3	1	102	1	0	0	0	0	1	0	0	0	10110	1261	44	2	917	2	N4BP2	4	40104376	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	29658161	40104376	151049900	50	31643										
CNOT6L	246175	broad.mit.edu	37	chr4	78650191	78650191	+	Missense_Mutation	SNP	C	C	T													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccaatgcatgtgggcatttgCcactataagcagctgtttgt							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78650191C>T	uc011ccd.1	-	10	1200	c.1069G>A	c.(1069-1071)GCA>ACA	p.A357T	CNOT6L_uc003hks.2_Missense_Mutation_p.A357T|CNOT6L_uc003hkt.1_Missense_Mutation_p.A200T	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	357					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding	p.V357I(1)		large_intestine(1)	1						TGGGCATTTGCCACTATAAGC	0.388													0	0	0	0.050027	0	23	61										T	78650191	C	T	78650191	3	4	102	1	0	0	0	0	1	0	0	0	3623	739	26	2	610	2	CNOT6L	4	78650191	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	38545815	78650191	112504085	51	31644	157	2								
CNOT6L	246175	broad.mit.edu	37	chr4	78650194	78650194	+	Missense_Mutation	SNP	C	C	G													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atgcatgtgggcatttgccaCtataagcagctgtttgtctg							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78650194C>G	uc011ccd.1	-	10	1197	c.1066G>C	c.(1066-1068)GTG>CTG	p.V356L	CNOT6L_uc003hks.2_Missense_Mutation_p.V356L|CNOT6L_uc003hkt.1_Missense_Mutation_p.V199L	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	356					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						GCATTTGCCACTATAAGCAGC	0.388													0	0	0	0.045705	0	22	60										G	78650194	C	G	78650194	3	3	102	1	0	0	0	0	1	0	0	0	3623	565	20	4	613	4	CNOT6L	4	78650194	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	3	78650194	112504082	52	31645	157	2								
MRPL1	65008	broad.mit.edu	37	chr4	78815330	78815330	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgttgcagacttttacgtagCtgttccagaaataatgcctg	9	8	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:78815330C>G	uc003hku.2	+	6	794	c.596C>G	c.(595-597)GCT>GGT	p.A199G	MRPL1_uc010iji.1_Missense_Mutation_p.A122G	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	199							RNA binding				0						TTTTACGTAGCTGTTCCAGAA	0.308													0	0	0	0.139131	0	37	75										G	78815330	C	G	78815330	3	3	102	1	0	0	0	0	1	0	0	0	9774	797	28	4	618	4	MRPL1	4	78815330	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	165136	78815330	112338946	53	31646										
AIMP1	9255	broad.mit.edu	37	chr4	107268795	107268795	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaaggagttccctttgaggtGaaagggaagggagtatgtag	16	3	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:107268795G>A	uc011cfg.1	+	7	937	c.885G>A	c.(883-885)GTG>GTA	p.V295V	AIMP1_uc003hyg.2_Silent_p.V295V|AIMP1_uc003hyh.2_Silent_p.V319V	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	295					angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						CCTTTGAGGTGAAAGGGAAGG	0.413													0	0	0	0.021553	0	4	44										A	107268795	G	A	107268795	2	1	102	1	0	0	0	0	0	0	0	1	433	1277	45	1		1	AIMP1	4	107268795	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	28453465	107268795	83885481	54	31647										
KIAA1109	84162	broad.mit.edu	37	chr4	123161005	123161005	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	attccagcatgtcaatggctGatagtgaagcctacttttct	8	9	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:123161005G>A	uc003ieh.2	+	27	4213	c.4168G>A	c.(4168-4170)GAT>AAT	p.D1390N	KIAA1109_uc003iei.1_Missense_Mutation_p.D1143N|KIAA1109_uc010ins.1_Missense_Mutation_p.D733N|KIAA1109_uc003iek.2_Missense_Mutation_p.D9N	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1390					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTCAATGGCTGATAGTGAAGC	0.418													0	0	0	0.069288	0	19	33										A	123161005	G	A	123161005	3	1	102	1	0	0	0	0	1	0	0	0	8208	1290	45	1	4274	1	KIAA1109	4	123161005	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	15892210	123161005	67993271	55	31648										
NPY2R	4887	broad.mit.edu	37	chr4	156135697	156135697	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccggactttgagattgtggcCtgtactgaaaagtggcctgg	14	8	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:156135697C>T	uc003ioq.2	+	2	1101	c.606C>T	c.(604-606)GCC>GCT	p.A202A	NPY2R_uc003ior.2_Silent_p.A202A	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	202	Extracellular (Potential).			A -> P (in Ref. 4; AAB07760).	cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				AGATTGTGGCCTGTACTGAAA	0.507													0	0	0	0.058154	0	8	129										T	156135697	C	T	156135697	2	4	102	1	0	0	0	0	0	0	0	1	10609	668	24	2		2	NPY2R	4	156135697	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	32974692	156135697	35018579	56	31649										
ZFP42	132625	broad.mit.edu	37	chr4	188924685	188924685	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atttcctggttcatactggaGagaagccgtttcggtgcact	11	9	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr4:188924685G>A	uc003izg.1	+	3	969	c.724G>A	c.(724-726)GAG>AAG	p.E242K	ZFP42_uc003izh.1_Missense_Mutation_p.E242K|ZFP42_uc003izi.1_Missense_Mutation_p.E242K	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	242					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCATACTGGAGAGAAGCCGTT	0.512													0	0	0	0.0333	0	15	27										A	188924685	G	A	188924685	3	1	102	1	0	0	0	0	1	0	0	0	17647	943	33	1	726	1	ZFP42	4	188924685	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	32788988	188924685	2229591	57	31650										
TRIM23	373	broad.mit.edu	37	chr5	64892995	64892995	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttccatttttggtccaatgtGaactcgattatcctacaatt	5	9	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:64892995G>C	uc003jty.2	-	8	1278	c.1192C>G	c.(1192-1194)CAC>GAC	p.H398D	TRIM23_uc003jtw.2_Missense_Mutation_p.H398D|TRIM23_uc003jtx.2_Missense_Mutation_p.H398D	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	398	ARF-like.				interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		GGTCCAATGTGAACTCGATTA	0.318													0	0	0	0.139131	0	49	57										C	64892995	G	C	64892995	3	2	102	1	0	0	0	0	1	0	0	0	16494	1290	45	1	615	1	TRIM23	5	64892995	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		64892995	116022265	58	31651										
MSH3	4437	broad.mit.edu	37	chr5	79950579	79950579	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aagcctgcgtcgggcggcctCgctgcctccagctcagcccc	12	19	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:79950579C>T	uc003kgz.2	+	1	286	c.33C>T	c.(31-33)CTC>CTT	p.L11L	DHFR_uc011ctl.1_5'UTR|DHFR_uc011ctm.1_5'UTR|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Silent_p.A59A|DHFR_uc003kgy.1_5'UTR	NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	11					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CGGGCGGCCTCGCTGCCTCCA	0.697								MMR					0	0	0	0.105934	0	9	25										T	79950579	C	T	79950579	2	4	102	1	0	0	0	0	0	0	0	1	9871	871	31	1		1	MSH3	5	79950579	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	15057584	79950579	100964681	59	31652										
SNCAIP	9627	broad.mit.edu	37	chr5	121767723	121767723	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acagaagccattgcagaactGagttgttctaaggattttcc	9	8	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:121767723G>A	uc003ksw.1	+	6	1448	c.1242G>A	c.(1240-1242)CTG>CTA	p.L414L	SNCAIP_uc011cwl.1_5'UTR|SNCAIP_uc010jct.2_Silent_p.L414L|SNCAIP_uc003ksx.1_Silent_p.L461L|SNCAIP_uc003ksy.1_Silent_p.L48L|SNCAIP_uc003ksz.1_Silent_p.L48L|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Silent_p.L48L|SNCAIP_uc003kta.1_Silent_p.L46L|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.L108L|SNCAIP_uc010jcx.1_Silent_p.L354L	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	414					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TTGCAGAACTGAGTTGTTCTA	0.403													0	0	0	0.086207	0	30	17										A	121767723	G	A	121767723	2	1	102	1	0	0	0	0	0	0	0	1	14841	1277	45	1		1	SNCAIP	5	121767723	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	41817144	121767723	59147537	60	31653										
PCDHB8	56128	broad.mit.edu	37	chr5	140558309	140558309	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcactgctcaggtctacattGaagttgtcgatgtcaatgat	10	8	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140558309G>A	uc011dai.1	+	1	880	c.694G>A	c.(694-696)GAA>AAA	p.E232K	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	232	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCTACATTGAAGTTGTCGA	0.507													0	0	0	0.124865	0	35	29										A	140558309	G	A	140558309	3	1	102	1	0	0	0	0	1	0	0	0	11548	1291	45	1	696	1	PCDHB8	5	140558309	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	18790586	140558309	40356951	61	31654										
PCDHB11	56125	broad.mit.edu	37	chr5	140581588	140581588	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggcaccgggaccctttcccaGagctaccagtacgaggtgtg	13	13	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140581588G>T	uc003liy.2	+	1	2241	c.2241G>T	c.(2239-2241)CAG>CAT	p.Q747H	PCDHB11_uc011daj.1_Missense_Mutation_p.Q382H	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	747	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTTTCCCAGAGCTACCAGT	0.582													1	0	2.18481e-45	0.139131	2.43524e-45	69	93										T	140581588	G	T	140581588	3	4	102	1	0	0	0	0	1	0	0	0	11536	933	33	3	2243	3	PCDHB11	5	140581588	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	23279	140581588	40333672	62	31655										
PCDHGA10	56106	broad.mit.edu	37	chr5	140793016	140793016	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcggcagcttgatcaccgcgGgcaggatagaccgggaggag	18	10	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:140793016G>T	uc003lkl.1	+	1	274	c.274G>T	c.(274-276)GGC>TGC	p.G92C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.G92C	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCACCGCGGGCAGGATAGA	0.602													1	0	3.19467e-53	0.139131	3.57498e-53	62	58										T	140793016	G	T	140793016	3	4	102	1	0	0	0	0	1	0	0	0	11551	1232	43	4	276	4	PCDHGA10	5	140793016	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	211428	140793016	40122244	63	31656										
RBM27	54439	broad.mit.edu	37	chr5	145609388	145609388	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggagaagaggcaggagtaaGagtcggagtaagagtcgagg	19	3	0	4			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:145609388G>C	uc003lnz.3	+	5	670	c.504G>C	c.(502-504)AAG>AAC	p.K168N	RBM27_uc003lny.2_Missense_Mutation_p.K168N	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	168	Arg-rich.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAggagtaagagtcggagta	0.428													0	0	0	0.124865	0	38	57										C	145609388	G	C	145609388	3	2	102	1	0	0	0	0	1	0	0	0	13127	933	33	1	522	1	RBM27	5	145609388	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	4816372	145609388	35305872	64	31657										
SPINK5	11005	broad.mit.edu	37	chr5	147475436	147475436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atcaaaatttgggaaaagctGaagaaaaaactaaagttaaa	7	3	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:147475436G>A	uc003lox.2	+	10	923	c.850G>A	c.(850-852)GAA>AAA	p.E284K	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.E256K|SPINK5_uc010jgr.2_Missense_Mutation_p.E265K|SPINK5_uc003low.2_Missense_Mutation_p.E284K|SPINK5_uc003loy.2_Missense_Mutation_p.E284K	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	284	Kazal-like 4.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAAAAGCTGAAGAAAAAAC	0.373													0	0	0	0.124865	0	35	30										A	147475436	G	A	147475436	3	1	102	1	0	0	0	0	1	0	0	0	15061	1291	45	1	888	1	SPINK5	5	147475436	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1866048	147475436	33439824	65	31658										
DOCK2	1794	broad.mit.edu	37	chr5	169461533	169461533	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagatgagagcaaagacaacCgcatgagctgcaccgtgaac	11	11	0	5			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:169461533C>T	uc003maf.2	+	35	3678	c.3598C>T	c.(3598-3600)CGC>TGC	p.R1200C	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R692C	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1200	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAAAGACAACCGCATGAGCTG	0.592													0	0	0	0.083992	0	19	46										T	169461533	C	T	169461533	3	4	102	1	0	0	0	0	1	0	0	0	4687	652	23	2	3736	2	DOCK2	5	169461533	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	21986097	169461533	11453727	66	31659										
KCNIP1	30820	broad.mit.edu	37	chr5	170145787	170145787	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	attgaagatgagctggagatGaccatggtttgccatcggcc	13	8	0	5			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:170145787G>A	uc003mas.2	+	3	649	c.120G>A	c.(118-120)ATG>ATA	p.M40I	KCNIP1_uc003map.2_Missense_Mutation_p.M38I|KCNIP1_uc003mat.2_Missense_Mutation_p.M29I|KCNIP1_uc010jjp.2_Missense_Mutation_p.M1I|KCNIP1_uc010jjq.2_Missense_Mutation_p.M29I	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	40	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCTGGAGATGACCATGGTTT	0.512													0	0	0	0.0333	0	13	23										A	170145787	G	A	170145787	3	1	102	1	0	0	0	0	1	0	0	0	8039	1290	45	1	222	1	KCNIP1	5	170145787	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	684254	170145787	10769473	67	31660										
RGS14	10636	broad.mit.edu	37	chr5	176794807	176794807	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggtcctgggggccgccctctCcgcaagtccttccgccgggg	15	17	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:176794807C>T	uc003mgf.2	+	7	902	c.720C>T	c.(718-720)CTC>CTT	p.L240L	RGS14_uc003mgg.1_Silent_p.L87L|RGS14_uc003mgh.2_Silent_p.L87L|RGS14_uc003mgi.2_5'UTR	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	240					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGCCCTCTCCGCAAGTCCT	0.652													0	0	0	0.11911	0	11	8										T	176794807	C	T	176794807	2	4	102	1	0	0	0	0	0	0	0	1	13297	842	30	1		1	RGS14	5	176794807	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	6649020	176794807	4120453	68	31661										
DBN1	1627	broad.mit.edu	37	chr5	176895189	176895189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtacatcaccttctggttctCaaagtgtcccgaaagctcct	7	13	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr5:176895189C>G	uc003mgy.2	-	3	347	c.175G>C	c.(175-177)GAG>CAG	p.E59Q	DBN1_uc003mgx.2_Missense_Mutation_p.E61Q|DBN1_uc010jkn.1_5'UTR|DBN1_uc003mgz.1_5'UTR	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	59	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCTGGTTCTCAAAGTGTCCC	0.552													0	0	0	0.139131	0	107	118										G	176895189	C	G	176895189	3	3	102	1	0	0	0	0	1	0	0	0	4252	835	29	1	1822	1	DBN1	5	176895189	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	100382	176895189	4020071	69	31662										
DEK	7913	broad.mit.edu	37	chr6	18264194	18264194	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggtgggggttccctccccctCcgcagcaggggccgaggcgg	18	15	0	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:18264194C>T	uc003ncr.1	-	2	218	c.25G>A	c.(25-27)GAG>AAG	p.E9K	DEK_uc011djf.1_Missense_Mutation_p.E9K|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	9					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			CCCTCCCCCTCCGCAGCAGGG	0.562			T	NUP214	AML								0	0	0	0.076483	0	18	29										T	18264194	C	T	18264194	3	4	102	1	0	0	0	0	1	0	0	0	4424	864	30	1	1142	1	DEK	6	18264194	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		18264194	152850873	70	31663										
PRSS16	10279	broad.mit.edu	37	chr6	27219016	27219016	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtggtatcccgaagcctaatGagcaccgcgatcggcgggtc	14	12	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:27219016G>A	uc003nja.2	+	7	702	c.690G>A	c.(688-690)ATG>ATA	p.M230I	PRSS16_uc011dkt.1_Intron|PRSS16_uc003njb.2_Intron|PRSS16_uc010jqq.1_Intron|PRSS16_uc010jqr.1_Intron|PRSS16_uc003njc.1_Intron|PRSS16_uc003njd.2_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	230					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						GAAGCCTAATGAGCACCGCGA	0.672													0	0	0	0.104719	0	29	28										A	27219016	G	A	27219016	3	1	102	1	0	0	0	0	1	0	0	0	12616	1290	45	1	716	1	PRSS16	6	27219016	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	8954822	27219016	143896051	71	31664										
HIST1H2BL	8340	broad.mit.edu	37	chr6	27775577	27775577	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tacacgtacacggagtagctCtccttgcggctgcgcttgcg	12	13	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:27775577C>T	uc003njl.2	-	1	133	c.108G>A	c.(106-108)GAG>GAA	p.E36E	HIST1H3H_uc003njm.2_5'Flank	NM_003519	NP_003510	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	36					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGGAGTAGCTCTCCTTGCGGC	0.587													0	0	0	0.139131	0	77	191										T	27775577	C	T	27775577	2	4	102	1	0	0	0	0	0	0	0	1	7151	912	32	1		1	HIST1H2BL	6	27775577	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	556561	27775577	143339490	72	31665										
OR14J1	442191	broad.mit.edu	37	chr6	29274779	29274779	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aggttttcttcttcatagctCtggcctcatcagaagtggcc	9	11	6	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:29274779C>T	uc011dln.1	+	1	313	c.313C>T	c.(313-315)CTG>TTG	p.L105L		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTTCATAGCTCTGGCCTCATC	0.453													0	0	0	0.139131	0	47	43										T	29274779	C	T	29274779	2	4	102	1	0	0	0	0	0	0	0	1	10948	912	32	1		1	OR14J1	6	29274779	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1499202	29274779	141840288	73	31666										
ZFP57	346171	broad.mit.edu	37	chr6	29640988	29640988	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggtgtctggaattcagcctgGgtgcctggaatcctcaaagt	13	9	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:29640988G>A	uc011dlw.1	-	4	1051	c.900C>T	c.(898-900)ACC>ACT	p.T300T	ZFP57_uc003nnl.3_Silent_p.T280T	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	216					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ATTCAGCCTGGGTGCCTGGAA	0.557													0	0	0	0.139131	0	103	23										A	29640988	G	A	29640988	2	1	102	1	0	0	0	0	0	0	0	1	17648	1219	43	2		2	ZFP57	6	29640988	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	366209	29640988	141474079	74	31667										
BACH2	60468	broad.mit.edu	37	chr6	90647890	90647890	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cggatttcacattctaaattCtgaatacagtccagtttcct	5	10	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:90647890C>T	uc011eab.1	-	8	2825	c.2016G>A	c.(2014-2016)CAG>CAA	p.Q672Q	BACH2_uc003pnw.2_Silent_p.Q672Q	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	672						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		ATTCTAAATTCTGAATACAGT	0.458													0	0	0	0.139131	0	58	19										T	90647890	C	T	90647890	2	4	102	1	0	0	0	0	0	0	0	1	1284	912	32	1		1	BACH2	6	90647890	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	61006902	90647890	80467177	75	31668										
ZBTB24	9841	broad.mit.edu	37	chr6	109803198	109803198	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgtctgagtgtacaacaagcTgcccagaaggctctggcgat	12	11	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:109803198T>C	uc003ptl.1	-	2	200	c.32A>G	c.(31-33)CAG>CGG	p.Q11R	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.Q11R|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Missense_Mutation_p.Q11R	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	11	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TACAACAAGCTGCCCAGAAGG	0.443													0	0	0	0.080422	0	29	13										C	109803198	T	C	109803198	3	2	102	1	0	0	0	0	1	0	0	0	17528	1580	55	5	2135	5	ZBTB24	6	109803198	Missense_Mutation	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	19155308	109803198	61311869	76	31669										
FYN	2534	broad.mit.edu	37	chr6	111983077	111983077	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atcatgagctcatgcagagaGatggggcagtcctgcgggca	15	9	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:111983077G>A	uc003pvj.2	-	13	1819	c.1479C>T	c.(1477-1479)ATC>ATT	p.I493I	FYN_uc003pvi.2_Silent_p.I438I|FYN_uc003pvk.2_Silent_p.I493I|FYN_uc003pvh.2_Silent_p.I490I	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	493	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	CATGCAGAGAGATGGGGCAGT	0.567													0	0	0	0.139131	0	82	47										A	111983077	G	A	111983077	2	1	102	1	0	0	0	0	0	0	0	1	6126	932	33	1		1	FYN	6	111983077	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	2179879	111983077	59131990	77	31670										
SYNE1	23345	broad.mit.edu	37	chr6	152737694	152737694	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagaaggttctggatcctctCtacctctccacagagctgat	8	13	3	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:152737694C>G	uc010kiw.2	-	41	6480	c.5878G>C	c.(5878-5880)GAG>CAG	p.E1960Q	SYNE1_uc003qot.3_Missense_Mutation_p.E1967Q|SYNE1_uc003qou.3_Missense_Mutation_p.E1960Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E1943Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1960	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGATCCTCTCTACCTCTCCA	0.502										HNSCC(10;0.0054)			0	0	0	0.02938	0	6	95										G	152737694	C	G	152737694	3	3	102	1	0	0	0	0	1	0	0	0	15442	922	32	1	21012	1	SYNE1	6	152737694	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	40754617	152737694	18377373	78	31671										
RBM16	22828	broad.mit.edu	37	chr6	155154524	155154524	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaagcacagaaactgaggggAcataatcatcactcagtagg	10	8	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:155154524A>G	uc003qqa.2	+	21	4043	c.3811A>G	c.(3811-3813)ACA>GCA	p.T1271A	TIAM2_uc003qqb.2_5'UTR|RBM16_uc011efj.1_Missense_Mutation_p.T1337A|RBM16_uc011efk.1_Missense_Mutation_p.T1316A|RBM16_uc003qpz.2_Missense_Mutation_p.T1271A	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	1271					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		AACTGAGGGGACATAATCATC	0.373													0	0	0	0.09836	0	35	22										G	155154524	A	G	155154524	3	3	102	1	0	0	0	0	1	0	0	0	13118	275	10	5	3889	5	RBM16	6	155154524	Missense_Mutation	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	2416830	155154524	15960543	79	31672										
TULP4	56995	broad.mit.edu	37	chr6	158922867	158922867	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aatgtgcagctagatgtcctGaccaaccagacgacagctgt	10	11	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:158922867G>A	uc003qrf.2	+	13	3529	c.2172G>A	c.(2170-2172)CTG>CTA	p.L724L	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	724					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		TAGATGTCCTGACCAACCAGA	0.567													0	0	0	0.139131	0	83	34										A	158922867	G	A	158922867	2	1	102	1	0	0	0	0	0	0	0	1	16773	1277	45	1		1	TULP4	6	158922867	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3768343	158922867	12192200	80	31673										
IGF2R	3482	broad.mit.edu	37	chr6	160500774	160500774	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggattacaggcaccaggatGaagcggtcgttttaagttac	12	7	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr6:160500774G>C	uc003qta.2	+	38	5789	c.5641G>C	c.(5641-5643)GAA>CAA	p.E1881Q		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1881	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GCACCAGGATGAAGCGGTCGT	0.458													0	0	0	0.080422	0	29	18										C	160500774	G	C	160500774	3	2	102	1	0	0	0	0	1	0	0	0	7576	1291	45	1	5791	1	IGF2R	6	160500774	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1577907	160500774	10614293	81	31674										
MICALL2	79778	broad.mit.edu	37	chr7	1481960	1481960	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgggggcaacgcggatgcctGagaggtactgctcgtgctca	16	11	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:1481960G>C	uc003skj.3	-	7	1726	c.1579C>G	c.(1579-1581)CAG>GAG	p.Q527E	MICALL2_uc003ski.3_Missense_Mutation_p.Q14E	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	527						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCGGATGCCTGAGAGGTACTG	0.667													0	0	0	0.139131	0	50	92										C	1481960	G	C	1481960	3	2	102	1	0	0	0	0	1	0	0	0	9574	1299	45	1	1179	1	MICALL2	7	1481960	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		1481960	157656703	82	31675										
IL6	3569	broad.mit.edu	37	chr7	22768323	22768323	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctttcccagacatgtaacaaGagtaacatgtgtgaaagcag	9	8	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:22768323G>C	uc011jyn.1	+	4	681	c.222G>C	c.(220-222)AAG>AAC	p.K74N	uc010kun.1_5'Flank|IL6_uc011jyo.1_Missense_Mutation_p.K74N|IL6_uc011jyp.1_5'UTR|IL6_uc003svj.3_Missense_Mutation_p.K74N|IL6_uc011jyq.1_Missense_Mutation_p.K128N	NM_000600	NP_000591	P05231	IL6_HUMAN	interleukin 6 precursor	74					acute-phase response|cellular response to hydrogen peroxide|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|endocrine pancreas development|glucagon secretion|hepatic immune response|interleukin-6-mediated signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of chemokine biosynthetic process|negative regulation of collagen biosynthetic process|negative regulation of fat cell differentiation|negative regulation of lipid storage|neuron projection development|neutrophil apoptosis|platelet activation|positive regulation of acute inflammatory response|positive regulation of anti-apoptosis|positive regulation of B cell activation|positive regulation of chemokine production|positive regulation of immunoglobulin secretion|positive regulation of interleukin-6 production|positive regulation of osteoblast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of smooth muscle cell proliferation|positive regulation of T cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of vascular endothelial growth factor production|response to glucocorticoid stimulus|response to peptidoglycan	extracellular space|interleukin-6 receptor complex	cytokine activity|growth factor activity|interleukin-6 receptor binding				0					Arsenic trioxide(DB01169)|Bicalutamide(DB01128)|Ginseng(DB01404)|Simvastatin(DB00641)	CATGTAACAAGAGTAACATGT	0.428													0	0	0	0.014758	0	5	59										C	22768323	G	C	22768323	3	2	102	1	0	0	0	0	1	0	0	0	7701	933	33	1	232	1	IL6	7	22768323	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	21286363	22768323	136370340	83	31676										
NUPL2	11097	broad.mit.edu	37	chr7	23239972	23239972	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cttttggatttgggaagcctGaagtcacatcggctgcatca	11	9	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:23239972G>A	uc003svu.2	+	7	1139	c.880G>A	c.(880-882)GAA>AAA	p.E294K	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Missense_Mutation_p.E171K|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Missense_Mutation_p.E171K|NUPL2_uc011jyx.1_Missense_Mutation_p.E66K	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	294	Ser-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						TGGGAAGCCTGAAGTCACATC	0.502													0	0	0	0.047766	0	9	10										A	23239972	G	A	23239972	3	1	102	1	0	0	0	0	1	0	0	0	10775	1291	45	1	906	1	NUPL2	7	23239972	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	471649	23239972	135898691	84	31677										
ASB4	51666	broad.mit.edu	37	chr7	95165794	95165794	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctaaagcaattgaagttgtaGtcaatgcctatgaacacatc	7	8	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:95165794G>A	uc011kij.1	+	4	1024	c.1024G>A	c.(1024-1026)GTC>ATC	p.V342I		NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	342					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			TGAAGTTGTAGTCAATGCCTA	0.408													0	0	0	0.146539	0	13	43										A	95165794	G	A	95165794	3	1	102	1	0	0	0	0	1	0	0	0	1025	1029	36	2	1110	2	ASB4	7	95165794	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	71925822	95165794	63972869	85	31678										
SRPK2	6733	broad.mit.edu	37	chr7	104758350	104758350	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcgtttttctggaaccatttCtaacatcgggatcaggaaat	8	8	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:104758350C>G	uc003vct.2	-	15	2189	c.2002G>C	c.(2002-2004)GAA>CAA	p.E668Q	SRPK2_uc003vcu.2_Missense_Mutation_p.E668Q|SRPK2_uc003vcv.2_Missense_Mutation_p.E679Q|uc003vcr.1_5'Flank|SRPK2_uc003vcs.1_RNA	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	668	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GGAACCATTTCTAACATCGGG	0.458													0	0	0	0.146539	0	14	31										G	104758350	C	G	104758350	3	3	102	1	0	0	0	0	1	0	0	0	15159	922	32	1	68	1	SRPK2	7	104758350	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	9592556	104758350	54380313	86	31679										
COG5	10466	broad.mit.edu	37	chr7	106938761	106938761	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtaataatttagggtattctCcttcaaatgcctgcttcaaa	6	8	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:106938761C>T	uc003ved.2	-	12	1757	c.1232G>A	c.(1231-1233)GGA>GAA	p.G411E	COG5_uc003vec.2_Missense_Mutation_p.G411E|COG5_uc003vee.2_Missense_Mutation_p.G411E	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	411					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						AGGGTATTCTCCTTCAAATGC	0.323													0	0	0	0.105934	0	11	26										T	106938761	C	T	106938761	3	4	102	1	0	0	0	0	1	0	0	0	3661	855	30	1	1398	1	COG5	7	106938761	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2180411	106938761	52199902	87	31680										
MKRN1	23608	broad.mit.edu	37	chr7	140158900	140158900	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccgtggagatacacacagttCtccccgtatcggcactctcc	8	16	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:140158900C>T	uc003vvt.2	-	4	903	c.678G>A	c.(676-678)GAG>GAA	p.E226E	MKRN1_uc003vvs.2_Silent_p.E162E|MKRN1_uc011krd.1_Intron|MKRN1_uc003vvv.3_Silent_p.E226E|MKRN1_uc003vvu.3_Silent_p.E162E	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	226	C3H1-type 3.						ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					ACACACAGTTCTCCCCGTATC	0.532													0	0	0	0.139131	0	43	97										T	140158900	C	T	140158900	2	4	102	1	0	0	0	0	0	0	0	1	9606	912	32	1		1	MKRN1	7	140158900	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	33220139	140158900	18979763	88	31681										
DENND2A	27147	broad.mit.edu	37	chr7	140273705	140273705	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggagggagggctgattttgGaaggggacccagttccatcc	16	8	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:140273705G>A	uc010lnj.2	-	4	1494	c.1349C>T	c.(1348-1350)TCC>TTC	p.S450F	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.S450F|DENND2A_uc003vvw.2_Missense_Mutation_p.S450F|DENND2A_uc003vvx.2_Missense_Mutation_p.S450F	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	450										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GCTGATTTTGGAAGGGGACCC	0.498													0	0	0	0.139131	0	42	109										A	140273705	G	A	140273705	3	1	102	1	0	0	0	0	1	0	0	0	4429	1174	41	1	1740	1	DENND2A	7	140273705	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	114805	140273705	18864958	89	31682										
CASP2	835	broad.mit.edu	37	chr7	142985599	142985599	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	accttccagcacaaggagctGatggccgctgacaggggacg	14	12	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:142985599G>T	uc003wco.2	+	1	198	c.51G>T	c.(49-51)CTG>CTT	p.L17L	CASP2_uc003wcp.2_Silent_p.L17L|CASP2_uc011kta.1_5'UTR|CASP2_uc003wcq.2_5'Flank	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	17					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)					ACAAGGAGCTGATGGCCGCTG	0.682													1	0	0.00198382	0.02938	0.00201963	4	14										T	142985599	G	T	142985599	2	4	102	1	0	0	0	0	0	0	0	1	2671	1277	45	3		3	CASP2	7	142985599	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	2711894	142985599	16153064	90	31683										
MLL3	58508	broad.mit.edu	37	chr7	151949045	151949045	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgtagtgagctcagctatctCcacttcctcacctggctgta	8	13	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:151949045C>A	uc003wla.2	-	11	1819	c.1600G>T	c.(1600-1602)GAG>TAG	p.E534*		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	534					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCAGCTATCTCCACTTCCTCA	0.358			N		medulloblastoma								1	0	2.27111e-07	0.09319	2.3633e-07	9	16										A	151949045	C	A	151949045	4	1	102	1	0	0	0	0	0	1	0	0	9622	864	30	3	13331	3	MLL3	7	151949045	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	8963446	151949045	7189618	91	31684										
VIPR2	7434	broad.mit.edu	37	chr7	158827298	158827298	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggaaattaaaatcggtattcGtatgacccaccagggcacac	9	10	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr7:158827298G>A	uc003woh.2	-	9	1039	c.853C>T	c.(853-855)CGA>TGA	p.R285*	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	285	Helical; Name=5; (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		ATCGGTATTCGTATGACCCAC	0.478													0	0	0	0.062417	0	18	47										A	158827298	G	A	158827298	4	1	102	1	0	0	0	0	0	1	0	0	17167	1153	40	2	483	2	VIPR2	7	158827298	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	6878253	158827298	311365	92	31685										
UBXN8	7993	broad.mit.edu	37	chr8	30620854	30620854	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gagaaggttttgaagtcctaCagctcacaggtaagtgaagg	13	6	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:30620854C>T	uc003xii.2	+	9	653	c.636C>T	c.(634-636)TAC>TAT	p.Y212Y	UBXN8_uc010lvi.2_3'UTR|UBXN8_uc011lbb.1_RNA|UBXN8_uc003xij.2_RNA	NM_005671	NP_005662	O00124	UBXN8_HUMAN	reproduction 8	212	UBX.				single fertilization						0						TGAAGTCCTACAGCTCACAGG	0.428													0	0	0	0.139131	0	35	28										T	30620854	C	T	30620854	2	4	102	1	0	0	0	0	0	0	0	1	16916	478	17	2		2	UBXN8	8	30620854	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		30620854	115743168	93	31686										
KCNU1	157855	broad.mit.edu	37	chr8	36642052	36642052	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcttcagtggactcatcatcCtgttgatcttcaggctgatc	8	11	6	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:36642052C>T	uc010lvw.2	+	1	211	c.124C>T	c.(124-126)CTG>TTG	p.L42L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	42	Helical; Name=Segment S0; (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCATCATCCTGTTGATCTT	0.428													0	0	0	0.069234	0	8	19										T	36642052	C	T	36642052	2	4	102	1	0	0	0	0	0	0	0	1	8093	680	24	2		2	KCNU1	8	36642052	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	6021198	36642052	109721970	94	31687										
GGH	8836	broad.mit.edu	37	chr8	63939794	63939794	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttagcataatctgagcgtctGaggtcaacacttcctccagg	9	11	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:63939794G>C	uc003xuw.2	-	4	589	c.306C>G	c.(304-306)CTC>CTG	p.L102L		NM_003878	NP_003869	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase precursor	102	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CTGAGCGTCTGAGGTCAACAC	0.383													0	0	0	0.131918	0	35	111										C	63939794	G	C	63939794	2	2	102	1	0	0	0	0	0	0	0	1	6357	1277	45	1		1	GGH	8	63939794	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	27297742	63939794	82424228	95	31688										
KCNB2	9312	broad.mit.edu	37	chr8	73849756	73849756	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaagtgaactttaaggaaaaTagaggcagtgcaccacagac	10	7	0	3	rs114148959	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:73849756T>C	uc003xzb.2	+	3	2754	c.2166T>C	c.(2164-2166)AAT>AAC	p.N722N		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	722	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTAAGGAAAATAGAGGCAGTG	0.537													0	0	0	0.139131	0	64	54										C	73849756	T	C	73849756	2	2	102	1	0	0	0	0	0	0	0	1	8013	1403	49	5		5	KCNB2	8	73849756	Silent	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	9909962	73849756	72514266	96	31689										
SNX31	169166	broad.mit.edu	37	chr8	101629926	101629926	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttgggcagaaatatgtccagAtaagctttcttggtggcgat	12	6	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:101629926A>G	uc003yjr.2	-	5	505	c.354T>C	c.(352-354)TAT>TAC	p.Y118Y	SNX31_uc011lhb.1_Silent_p.Y19Y	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	118					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATATGTCCAGATAAGCTTTCT	0.303													0	0	0	0.086207	0	32	105										G	101629926	A	G	101629926	2	3	102	1	0	0	0	0	0	0	0	1	14901	340	12	5		5	SNX31	8	101629926	Silent	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	27780170	101629926	44734096	97	31690										
CSMD3	114788	broad.mit.edu	37	chr8	114185980	114185981	+	Missense_Mutation	DNP	GA	GA	AT													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	taggaacaggaaaatcccacGaagctgtattaactgaattg							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:114185980_114185981GA>AT	uc003ynu.2	-	4	838_839	c.679_680TC>AT	c.(679-681)TCG>ATG	p.S227M	CSMD3_uc003ynt.2_Missense_Mutation_p.S187M|CSMD3_uc011lhx.1_Missense_Mutation_p.S227M|CSMD3_uc010mcx.1_Missense_Mutation_p.S227M	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	227	Extracellular (Potential).|Sushi 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAAATCCCACGAAGCTGTATTA	0.431										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.115264	0	41	138										AT	114185981	GA	AT	114185980	3	1	102	1	0	0	0	0	1	0	0	0	3946	1059	37	1	10715	1	CSMD3	8	114185980	Missense_Mutation	DNP	GA	TCGA-GC-A3I6-01A-11D-A20D-08	12556054	114185980	32178042	98	31691										
ATAD2	29028	broad.mit.edu	37	chr8	124382256	124382256	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttcttggtcttcaccctcttCagatgactctacaattaaga	5	11	6	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:124382256C>T	uc003yqh.3	-	7	844	c.736G>A	c.(736-738)GAA>AAA	p.E246K	ATAD2_uc011lii.1_Missense_Mutation_p.E37K|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E246K	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TCACCCTCTTCAGATGACTCT	0.234													0	0	0	0.139131	0	45	44										T	124382256	C	T	124382256	3	4	102	1	0	0	0	0	1	0	0	0	1071	835	29	1	3524	1	ATAD2	8	124382256	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	10196276	124382256	21981766	99	31692										
RHPN1	114822	broad.mit.edu	37	chr8	144457813	144457813	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttgacaaggagctgcagatgCggacgggcgctgagaacctc	15	10	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:144457813C>T	uc003yyb.2	+	2	284	c.151C>T	c.(151-153)CGG>TGG	p.R51W		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	51	REM.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			GCTGCAGATGCGGACGGGCGC	0.672													0	0	0	0.144211	0	24	20										T	144457813	C	T	144457813	3	4	102	1	0	0	0	0	1	0	0	0	13350	759	27	2	157	2	RHPN1	8	144457813	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	20075557	144457813	1906209	100	31693										
GPR172A	79581	broad.mit.edu	37	chr8	145583069	145583069	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggagctacctgtggtggtcaAagagcttccagagggtgagt	16	7	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr8:145583069A>G	uc003zcc.1	+	2	273	c.116A>G	c.(115-117)AAA>AGA	p.K39R	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.K39R|GPR172A_uc003zce.1_Missense_Mutation_p.K39R|GPR172A_uc010mfy.1_Missense_Mutation_p.K39R|GPR172A_uc003zcf.1_Missense_Mutation_p.K39R|GPR172A_uc011llc.1_Intron	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	39						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GTGGTGGTCAAAGAGCTTCCA	0.647													0	0	0	0.115264	0	3	40										G	145583069	A	G	145583069	3	3	102	1	0	0	0	0	1	0	0	0	6669	14	1	5	118	5	GPR172A	8	145583069	Missense_Mutation	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	1125256	145583069	780953	101	31694										
TLE1	7088	broad.mit.edu	37	chr9	84235445	84235445	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcgtttatctgtgcctcttaGactgtctgggaccaggaggg	14	9	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:84235445G>A	uc004aly.2	-	9	1063	c.622C>T	c.(622-624)CTA>TTA	p.L208L	TLE1_uc004alz.2_Silent_p.L218L|TLE1_uc011lsr.1_Silent_p.L208L|TLE1_uc004ama.1_Silent_p.L208L|TLE1_uc011lss.1_Silent_p.L134L	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	208	CCN domain.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GTGCCTCTTAGACTGTCTGGG	0.408													0	0	0	0.043863	0	16	50										A	84235445	G	A	84235445	2	1	102	1	0	0	0	0	0	0	0	1	15935	933	33	1		1	TLE1	9	84235445	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		84235445	56977986	102	31695										
SUSD3	203328	broad.mit.edu	37	chr9	95840160	95840160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acgagacctttggcttcaagGtggccgtgatcgcctccatt	11	12	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:95840160G>A	uc004atb.2	+	3	346	c.310G>A	c.(310-312)GTG>ATG	p.V104M	SUSD3_uc004atc.2_Missense_Mutation_p.V91M	NM_145006	NP_659443	Q96L08	SUSD3_HUMAN	sushi domain containing 3	104	Helical; (Potential).					integral to membrane				breast(2)|skin(2)|ovary(1)|lung(1)	6						TGGCTTCAAGGTGGCCGTGAT	0.597													0	0	0	0.059317	0	27	33										A	95840160	G	A	95840160	3	1	102	1	0	0	0	0	1	0	0	0	15406	1261	44	2	320	2	SUSD3	9	95840160	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	11604715	95840160	45373271	103	31696										
ZNF462	58499	broad.mit.edu	37	chr9	109688322	109688322	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcagagcaaaattaaccaaaCcaaacagcaggaagatgcag	8	9	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:109688322C>G	uc004bcz.2	+	3	2418	c.2129C>G	c.(2128-2130)ACC>AGC	p.T710S	ZNF462_uc010mto.2_Missense_Mutation_p.T558S|ZNF462_uc004bda.2_Missense_Mutation_p.T558S	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	710					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ATTAACCAAACCAAACAGCAG	0.453													0	0	0	0.086207	0	36	70										G	109688322	C	G	109688322	3	3	102	1	0	0	0	0	1	0	0	0	17923	507	18	4	2135	4	ZNF462	9	109688322	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	13848162	109688322	31525109	104	31697										
AK1	203	broad.mit.edu	37	chr9	130630320	130630320	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tccaggtgggtgcagacctgGgagaagacactgtccacgga	15	10	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130630320G>A	uc004bsm.3	-	7	705	c.552C>T	c.(550-552)TCC>TCT	p.S184S		NM_000476	NP_000467	P00568	KAD1_HUMAN	adenylate kinase 1	184					ATP metabolic process|nucleobase, nucleoside and nucleotide interconversion	cytosol	adenylate kinase activity|ATP binding|protein binding				0						TGCAGACCTGGGAGAAGACAC	0.662													0	0	0	0.076483	0	20	41										A	130630320	G	A	130630320	2	1	102	1	0	0	0	0	0	0	0	1	439	1219	43	2		2	AK1	9	130630320	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	20941998	130630320	10583111	105	31698										
ST6GALNAC4	27090	broad.mit.edu	37	chr9	130670821	130670821	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cactcatctagccggcccttCtcaaagtagtggtaaggcac	9	13	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130670821C>G	uc004bss.2	-	6	1035	c.759G>C	c.(757-759)GAG>GAC	p.E253D	ST6GALNAC4_uc004bst.2_Missense_Mutation_p.E169D	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a	253	Lumenal (Potential).				glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						GCCGGCCCTTCTCAAAGTAGT	0.647													0	0	0	0.139131	0	44	48										G	130670821	C	G	130670821	3	3	102	1	0	0	0	0	1	0	0	0	15225	912	32	1	153	1	ST6GALNAC4	9	130670821	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	40501	130670821	10542610	106	31699										
FAM102A	399665	broad.mit.edu	37	chr9	130742369	130742369	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcagtcagctcctccagggtGaaagtagtttggaatttgaa	12	7	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:130742369G>A	uc004bsx.1	-	1	127	c.48C>T	c.(46-48)TTC>TTT	p.F16F		NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	16										ovary(1)	1						CCTCCAGGGTGAAAGTAGTTT	0.522													0	0	0	0.139131	0	51	107										A	130742369	G	A	130742369	2	1	102	1	0	0	0	0	0	0	0	1	5382	1281	45	1		1	FAM102A	9	130742369	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	71548	130742369	10471062	107	31700										
AGPAT2	10555	broad.mit.edu	37	chr9	139571568	139571568	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggcgatctgcacgcagcgctCcggaaggacctccatgaggc	14	14	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:139571568C>A	uc004cii.1	-	3	439	c.337G>T	c.(337-339)GAG>TAG	p.E113*	AGPAT2_uc004cij.1_Nonsense_Mutation_p.E113*	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	113					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		ACGCAGCGCTCCGGAAGGACC	0.547													1	0	0.00621372	0.058154	0.00630312	9	22										A	139571568	C	A	139571568	4	1	102	1	0	0	0	0	0	1	0	0	387	864	30	3	515	3	AGPAT2	9	139571568	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	8829199	139571568	1641863	108	31701										
COBRA1	25920	broad.mit.edu	37	chr9	140151344	140151344	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgagcctgcgccgtggaggtGaagcggcagatctggcaaga	17	10	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr9:140151344G>A	uc004cmm.3	+	4	638	c.435G>A	c.(433-435)GTG>GTA	p.V145V		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	145					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		CCGTGGAGGTGAAGCGGCAGA	0.567													0	0	0	0.058154	0	7	35										A	140151344	G	A	140151344	2	1	102	1	0	0	0	0	0	0	0	1	3655	1277	45	1		1	COBRA1	9	140151344	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	579776	140151344	1062087	109	31702										
GDF2	2658	broad.mit.edu	37	chr10	48414156	48414156	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gacactgatgtccagcgtgtCgcagcccttcctgtggctct	11	14	1	1	rs137873272		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:48414156C>T	uc001jfa.1	-	2	875	c.712G>A	c.(712-714)GAC>AAC	p.D238N		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	238					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						TCCAGCGTGTCGCAGCCCTTC	0.577													0	0	0	0.146539	0	14	21										T	48414156	C	T	48414156	3	4	102	1	0	0	0	0	1	0	0	0	6314	884	31	1	581	1	GDF2	10	48414156	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		48414156	87120591	110	31703										
OGDHL	55753	broad.mit.edu	37	chr10	50952768	50952768	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggacctgccataagcctcctCacagatccggtcgtatttgg	10	13	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:50952768C>T	uc001jie.2	-	13	1802	c.1660G>A	c.(1660-1662)GAG>AAG	p.E554K	OGDHL_uc009xog.2_Missense_Mutation_p.E581K|OGDHL_uc010qgt.1_Missense_Mutation_p.E497K|OGDHL_uc010qgu.1_Missense_Mutation_p.E345K|OGDHL_uc009xoh.2_Missense_Mutation_p.E345K	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	554					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TAAGCCTCCTCACAGATCCGG	0.542													0	0	0	0.0918	0	21	40										T	50952768	C	T	50952768	3	4	102	1	0	0	0	0	1	0	0	0	10840	835	29	1	1416	1	OGDHL	10	50952768	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2538612	50952768	84581979	111	31704										
TET1	80312	broad.mit.edu	37	chr10	70446167	70446167	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgggtgttattcctcaagatGagcagctccatgtgctacct	10	10	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:70446167G>A	uc001jok.3	+	11	5612	c.5107G>A	c.(5107-5109)GAG>AAG	p.E1703K		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1703					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TCCTCAAGATGAGCAGCTCCA	0.453													0	0	0	0.099896	0	22	53										A	70446167	G	A	70446167	3	1	102	1	0	0	0	0	1	0	0	0	15766	1291	45	1	5145	1	TET1	10	70446167	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	19493399	70446167	65088580	112	31705										
HKDC1	80201	broad.mit.edu	37	chr10	71008378	71008378	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gagcagctcgtggacgtgcaGgccaagatgcgggctgagct	17	10	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:71008378G>A	uc001jpf.3	+	10	1597	c.1464G>A	c.(1462-1464)CAG>CAA	p.Q488Q	HKDC1_uc010qje.1_Silent_p.Q351Q	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	488					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						TGGACGTGCAGGCCAAGATGC	0.667													0	0	0	0.069234	0	9	15										A	71008378	G	A	71008378	2	1	102	1	0	0	0	0	0	0	0	1	7193	991	35	2		2	HKDC1	10	71008378	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	562211	71008378	64526369	113	31706										
FGF8	2253	broad.mit.edu	37	chr10	103534601	103534601	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtccggatgaggcggcggctGagctgatccgtcaccaggct	16	12	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:103534601G>C	uc001ktp.1	-	4	362	c.192C>G	c.(190-192)CTC>CTG	p.L64L	FGF8_uc001ktq.1_Silent_p.L75L|FGF8_uc001ktr.1_Silent_p.L46L|FGF8_uc001kts.1_Silent_p.L35L|FGF8_uc009xwr.1_5'UTR	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	64					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		GGCGGCGGCTGAGCTGATCCG	0.542													0	0	0	0.069234	0	10	19										C	103534601	G	C	103534601	2	2	102	1	0	0	0	0	0	0	0	1	5858	1277	45	1		1	FGF8	10	103534601	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	32526223	103534601	32000146	114	31707										
C10orf79	80217	broad.mit.edu	37	chr10	105903255	105903255	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaccaaagggtccaagccttCtggcatgttactaatattgt	9	9	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:105903255C>T	uc001kxw.2	-	32	4203	c.4087G>A	c.(4087-4089)GAA>AAA	p.E1363K	C10orf79_uc009xxq.2_Missense_Mutation_p.E642K	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1363											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TCCAAGCCTTCTGGCATGTTA	0.383													0	0	0	0.108266	0	22	53										T	105903255	C	T	105903255	3	4	102	1	0	0	0	0	1	0	0	0	1618	922	32	1	938	1	C10orf79	10	105903255	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2368654	105903255	29631492	115	31708										
SORCS3	22986	broad.mit.edu	37	chr10	106960946	106960946	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccaggagctcagtgtgccctGggccgagaccactcaggatc	13	14	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:106960946G>A	uc001kyi.1	+	16	2423	c.2196G>A	c.(2194-2196)CTG>CTA	p.L732L	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	732	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AGTGTGCCCTGGGCCGAGACC	0.488													0	0	0	0.0918	0	22	45										A	106960946	G	A	106960946	2	1	102	1	0	0	0	0	0	0	0	1	14932	1335	47	2		2	SORCS3	10	106960946	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1057691	106960946	28573801	116	31709										
SORCS1	114815	broad.mit.edu	37	chr10	108371675	108371675	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctgtgtgcactcacttccacCagggattttttgatgactcg	9	11	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:108371675C>T	uc001kym.2	-	22	3035	c.3027G>A	c.(3025-3027)CTG>CTA	p.L1009L	SORCS1_uc001kyl.2_Silent_p.L1009L|SORCS1_uc009xxs.2_Silent_p.L1009L|SORCS1_uc001kyn.1_Silent_p.L1009L|SORCS1_uc001kyo.2_Silent_p.L1009L	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1009	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCACTTCCACCAGGGATTTTT	0.483													0	0	0	0.02938	0	6	23										T	108371675	C	T	108371675	2	4	102	1	0	0	0	0	0	0	0	1	14930	581	21	2		2	SORCS1	10	108371675	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1410729	108371675	27163072	117	31710										
SORCS1	114815	broad.mit.edu	37	chr10	108923757	108923757	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggccagaccagtggaccatGgcttggttgtgtgctgagtc	15	9	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:108923757G>T	uc001kym.2	-	1	536	c.528C>A	c.(526-528)GCC>GCA	p.A176A	SORCS1_uc001kyl.2_Silent_p.A176A|SORCS1_uc009xxs.2_Silent_p.A176A|SORCS1_uc001kyn.1_Silent_p.A176A|SORCS1_uc001kyo.2_Silent_p.A176A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	176	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGTGGACCATGGCTTGGTTGT	0.582													1	0	2.89027e-11	0.069288	3.09907e-11	19	36										T	108923757	G	T	108923757	2	4	102	1	0	0	0	0	0	0	0	1	14930	1335	47	4		4	SORCS1	10	108923757	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	552082	108923757	26610990	118	31711										
SMC3	9126	broad.mit.edu	37	chr10	112349666	112349666	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttagctacttgtggagagaaGagaatgcagaacagcaagca	12	6	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:112349666G>A	uc001kze.2	+	15	1552	c.1426G>A	c.(1426-1428)GAG>AAG	p.E476K		NM_005445	NP_005436	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	476	Potential.				cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GTGGAGAGAAGAGAATGCAGA	0.358													0	0	0	0.144211	0	22	41										A	112349666	G	A	112349666	3	1	102	1	0	0	0	0	1	0	0	0	14784	943	33	1	1484	1	SMC3	10	112349666	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3425909	112349666	23185081	119	31712										
WDR11	55717	broad.mit.edu	37	chr10	122648591	122648591	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgttgctgttgttttctaggGaagtatgggtagtattacct	12	4	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:122648591G>A	uc010qtf.1	+	17	2361	c.2123G>A	c.(2122-2124)GGA>GAA	p.G708E	WDR11_uc010qte.1_Missense_Mutation_p.G310E|WDR11_uc001lfd.1_Missense_Mutation_p.G226E|WDR11_uc009xzn.2_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	708	WD 6.					integral to membrane					0						GTTTTCTAGGGAAGTATGGGT	0.313													0	0	0	0.069456	0	30	57										A	122648591	G	A	122648591	3	1	102	1	0	0	0	0	1	0	0	0	17270	1188	41	1	2189	1	WDR11	10	122648591	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	10298925	122648591	12886156	120	31713										
C10orf93	255352	broad.mit.edu	37	chr10	134750515	134750515	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gacaggctaatggaatttttCttttcttcctttaactgaag	7	7	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr10:134750515C>G	uc001llt.1	-	7	781	c.705G>C	c.(703-705)AAG>AAC	p.K235N		NM_173572	NP_775843	Q5SR76	CJ093_HUMAN	hypothetical protein LOC255352	235							binding			pancreas(1)	1		all_cancers(35;1.8e-07)|all_epithelial(44;6.22e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Colorectal(31;0.119)|Glioma(114;0.172)|Melanoma(40;0.175)		Epithelial(32;4.28e-05)|OV - Ovarian serous cystadenocarcinoma(35;4.31e-05)|all cancers(32;5.02e-05)		TGGAATTTTTCTTTTCTTCCT	0.274													0	0	0	0.014758	0	4	13										G	134750515	C	G	134750515	3	3	102	1	0	0	0	0	1	0	0	0	1625	912	32	1	524	1	C10orf93	10	134750515	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	12101924	134750515	784232	121	31714										
DKK3	27122	broad.mit.edu	37	chr11	11986170	11986170	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gggacctctctgggcagcagGatctccccatcttggtcacg	12	14	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:11986170G>A	uc001mju.2	-	7	951	c.894C>T	c.(892-894)ATC>ATT	p.I298I	DKK3_uc010rcf.1_Silent_p.I270I|DKK3_uc001mjv.2_Silent_p.I298I|DKK3_uc001mjw.2_Silent_p.I298I|DKK3_uc010rcg.1_Silent_p.I312I	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	298					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		TGGGCAGCAGGATCTCCCCAT	0.597													0	0	0	0.055883	0	19	13										A	11986170	G	A	11986170	2	1	102	1	0	0	0	0	0	0	0	1	4546	1164	41	1		1	DKK3	11	11986170	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		11986170	123020346	122	31715										
P2RX3	5024	broad.mit.edu	37	chr11	57135555	57135555	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaggcttttggcatccgcttCgacgtgctggtatacgggaa	13	9	0	0	rs150261482		TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:57135555C>T	uc001nju.2	+	9	991	c.915C>T	c.(913-915)TTC>TTT	p.F305F		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	305	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GCATCCGCTTCGACGTGCTGG	0.567													0	0	0	0.0333	0	12	76										T	57135555	C	T	57135555	2	4	102	1	0	0	0	0	0	0	0	1	11341	883	31	1		1	P2RX3	11	57135555	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	45149385	57135555	77870961	123	31716										
SLC43A3	29015	broad.mit.edu	37	chr11	57188794	57188794	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aggttggtgatgagaaacagGattcccccaatggtgagcat	13	7	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:57188794G>A	uc001nkg.2	-	6	824	c.414C>T	c.(412-414)ATC>ATT	p.I138I	PRG2_uc001nke.2_Silent_p.I37I|SLC43A3_uc001nkh.2_Silent_p.I138I|SLC43A3_uc010rjr.1_Silent_p.I151I|SLC43A3_uc009yme.2_Silent_p.I138I|SLC43A3_uc001nki.2_Silent_p.I138I|SLC43A3_uc009ymf.1_Silent_p.I138I|SLC43A3_uc010rjs.1_Silent_p.I138I|SLC43A3_uc009ymg.1_Silent_p.I151I	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	138	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)	1						TGAGAAACAGGATTCCCCCAA	0.562													0	0	0	0.0333	0	16	24										A	57188794	G	A	57188794	2	1	102	1	0	0	0	0	0	0	0	1	14634	1164	41	1		1	SLC43A3	11	57188794	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	53239	57188794	77817722	124	31717										
AHNAK	79026	broad.mit.edu	37	chr11	62297946	62297946	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gggggccttgaagtgcatctCaggcatcttaaacttggggc	14	9	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:62297946C>T	uc001ntl.2	-	5	4243	c.3943G>A	c.(3943-3945)GAG>AAG	p.E1315K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1315					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAGTGCATCTCAGGCATCTTA	0.522													0	0	0	0.047766	0	8	186										T	62297946	C	T	62297946	3	4	102	1	0	0	0	0	1	0	0	0	414	835	29	1	13849	1	AHNAK	11	62297946	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	5109152	62297946	72708570	125	31718										
TIGD3	220359	broad.mit.edu	37	chr11	65124162	65124162	+	Frame_Shift_Del	DEL	C	C	-													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccgcctctagcaccacgcctCccctgcccagctcagtggtc							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:65124162delC	uc001odo.3	+	2	1046	c.883delC	c.(883-885)CCCfs	p.P295fs		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	295	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CACCACGCCTCCCCTGCCCAG	0.652																		24	69	---	---								-	65124162	C	-	65124162	7	5	102	1	0	1	0	1	0	0	0	0	15894	855	30	0	885	0	TIGD3	11	65124162	Frame_Shift_Del	DEL	C	TCGA-GC-A3I6-01A-11D-A20D-08	2826216	65124162	69882354	126	31719										
LTBP3	4054	broad.mit.edu	37	chr11	65315174	65315174	+	Frame_Shift_Del	DEL	C	C	-													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgctcacccacgcacgagcgCcccccggcgcccacgtgcag							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:65315174delC	uc001oej.2	-	13	2234	c.1965delG	c.(1963-1965)GGGfs	p.G655fs	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Frame_Shift_Del_p.G85fs|LTBP3_uc010roi.1_Frame_Shift_Del_p.G538fs|LTBP3_uc001oei.2_Frame_Shift_Del_p.G655fs|LTBP3_uc010roj.1_Frame_Shift_Del_p.G356fs|LTBP3_uc010rok.1_Frame_Shift_Del_p.G566fs	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	655	EGF-like 4; calcium-binding (Potential).|Cys-rich.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CGCACGAGCGCCCCCCGGCGC	0.736																		2	4	---	---								-	65315174	C	-	65315174	7	5	102	1	0	1	0	1	0	0	0	0	9075	726	26	0	2010	0	LTBP3	11	65315174	Frame_Shift_Del	DEL	C	TCGA-GC-A3I6-01A-11D-A20D-08	191012	65315174	69691342	127	31720										
POLD3	10714	broad.mit.edu	37	chr11	74340342	74340342	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaggagaagaatcaaacttcCtgaatctgatagcagtgaag	11	6	2	5			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:74340342C>G	uc001ovf.1	+	9	1055	c.980C>G	c.(979-981)CCT>CGT	p.P327R	POLD3_uc009yua.1_Missense_Mutation_p.P221R	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	327					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					ATCAAACTTCCTGAATCTGAT	0.388													0	0	0	0.014758	0	4	72										G	74340342	C	G	74340342	3	3	102	1	0	0	0	0	1	0	0	0	12192	681	24	4	1014	4	POLD3	11	74340342	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	9025168	74340342	60666174	128	31721										
FOLH1B	219595	broad.mit.edu	37	chr11	89405073	89405073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agacagatatgtcattctggGaggtcaccgggactcatggg	14	8	4	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:89405073G>A	uc001pda.2	+	5	726	c.200G>A	c.(199-201)GGA>GAA	p.G67E		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	67					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GTCATTCTGGGAGGTCACCGG	0.408													0	0	0	0.045705	0	17	60										A	89405073	G	A	89405073	3	1	102	1	0	0	0	0	1	0	0	0	5980	1174	41	1	210	1	FOLH1B	11	89405073	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	15064731	89405073	45601443	129	31722										
UBE4A	9354	broad.mit.edu	37	chr11	118257262	118257262	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggcctacagatgtttggacAgctggcacgtttccataaca	10	10	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:118257262A>G	uc001psw.2	+	16	2651	c.2522A>G	c.(2521-2523)CAG>CGG	p.Q841R	UBE4A_uc001psv.2_Missense_Mutation_p.Q848R	NM_004788	NP_004779	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	841					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		ATGTTTGGACAGCTGGCACGT	0.468													0	0	0	0.139131	0	48	154										G	118257262	A	G	118257262	3	3	102	1	0	0	0	0	1	0	0	0	16879	188	7	5	2601	5	UBE4A	11	118257262	Missense_Mutation	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	28852189	118257262	16749254	130	31723										
CDON	50937	broad.mit.edu	37	chr11	125889642	125889642	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	taataacatgctttgtggatGaaccaaaatcaccaagaact	6	8	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr11:125889642G>A	uc009zbw.2	-	4	496	c.368C>T	c.(367-369)TCA>TTA	p.S123L	CDON_uc001qdc.3_Missense_Mutation_p.S123L|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.S123L	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	123	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTTTGTGGATGAACCAAAATC	0.353													0	0	0	0.132662	0	13	30										A	125889642	G	A	125889642	3	1	102	1	0	0	0	0	1	0	0	0	3170	1294	45	1	3494	1	CDON	11	125889642	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	7632380	125889642	9116874	131	31724										
ATF7IP	55729	broad.mit.edu	37	chr12	14649244	14649244	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggatcaacaggacctcagctCacagtgcatcaccgaccacc	8	16	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:14649244C>T	uc001rbw.2	+	14	3518	c.3360C>T	c.(3358-3360)CTC>CTT	p.L1120L	ATF7IP_uc001rbx.2_Silent_p.L1119L|ATF7IP_uc001rby.3_Silent_p.L1120L|ATF7IP_uc001rca.2_Silent_p.L1120L	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1120					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GACCTCAGCTCACAGTGCATC	0.393													0	0	0	0.099896	0	20	38										T	14649244	C	T	14649244	2	4	102	1	0	0	0	0	0	0	0	1	1087	813	29	1		1	ATF7IP	12	14649244	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		14649244	119202651	132	31725										
HIST4H4	121504	broad.mit.edu	37	chr12	14923749	14923749	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtgcgaccctggcgtttcagCgcgtacaccacatccatggc	11	15	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:14923749C>T	uc001rcf.3	-	1	317	c.270G>A	c.(268-270)GCG>GCA	p.A90A	HIST4H4_uc001rce.2_RNA	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	90					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						GGCGTTTCAGCGCGTACACCA	0.582											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	52	46										T	14923749	C	T	14923749	2	4	102	1	0	0	0	0	0	0	0	1	7185	755	27	2		2	HIST4H4	12	14923749	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	274505	14923749	118928146	133	31726										
PKP2	5318	broad.mit.edu	37	chr12	33021978	33021978	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctcactgctcgctccagagtCatctccatgtctgcattcct	6	16	4	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:33021978C>T	uc001rlj.3	-	4	1168	c.1053G>A	c.(1051-1053)ATG>ATA	p.M351I	PKP2_uc001rlk.3_Missense_Mutation_p.M351I|PKP2_uc010skj.1_Missense_Mutation_p.M351I	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	351	ARM 1.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GCTCCAGAGTCATCTCCATGT	0.527													0	0	0	0.139131	0	59	54										T	33021978	C	T	33021978	3	4	102	1	0	0	0	0	1	0	0	0	11985	826	29	1	1636	1	PKP2	12	33021978	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	18098229	33021978	100829917	134	31727										
MLL2	8085	broad.mit.edu	37	chr12	49435941	49435941	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aggtgagatggtggacagctGgcccaactcctcatccttct	11	12	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:49435941G>A	uc001rta.3	-	28	6040	c.6040C>T	c.(6040-6042)CAG>TAG	p.Q2014*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2014					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGACAGCTGGCCCAACTCC	0.577			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.105934	0	11	13										A	49435941	G	A	49435941	4	1	102	1	0	0	0	0	0	1	0	0	9621	1357	47	2	10681	2	MLL2	12	49435941	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	16413963	49435941	84415954	135	31728										
SPRYD3	84926	broad.mit.edu	37	chr12	53460407	53460407	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acatgattccacagcccatgAtgtcccctttgtaacagcgt	7	13	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:53460407A>T	uc001sbt.1	-	9	992	c.971T>A	c.(970-972)ATC>AAC	p.I324N	SPRYD3_uc010snw.1_Missense_Mutation_p.I150N	NM_032840	NP_116229	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	324										central_nervous_system(1)	1						ACAGCCCATGATGTCCCCTTT	0.587											OREG0021856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.069234	0	9	19										T	53460407	A	T	53460407	3	4	102	1	0	0	0	0	1	0	0	0	15108	333	12	5	369	5	SPRYD3	12	53460407	Missense_Mutation	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	4024466	53460407	80391488	136	31729										
PAN2	9924	broad.mit.edu	37	chr12	56720165	56720165	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	caccttcttcatggtgcgcaGaatctctgcatccacgggtg	10	13	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:56720165G>C	uc001skx.2	-	8	1664	c.1291C>G	c.(1291-1293)CTG>GTG	p.L431V	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.L431V|PAN2_uc001sky.2_Missense_Mutation_p.L431V	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	431					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ATGGTGCGCAGAATCTCTGCA	0.572													0	0	0	0.021553	0	4	17										C	56720165	G	C	56720165	3	2	102	1	0	0	0	0	1	0	0	0	11414	933	33	1	2393	1	PAN2	12	56720165	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3259758	56720165	77131730	137	31730										
PLXNC1	10154	broad.mit.edu	37	chr12	94658921	94658921	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agaaaattaacaagggtcccGtggatgtaatcacttgcaaa	9	7	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:94658921G>A	uc001tdc.2	+	21	3766	c.3517G>A	c.(3517-3519)GTG>ATG	p.V1173M	PLXNC1_uc010sut.1_Missense_Mutation_p.V220M|PLXNC1_uc009zsv.2_Translation_Start_Site	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1173	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CAAGGGTCCCGTGGATGTAAT	0.448													0	0	0	0.139131	0	109	139										A	94658921	G	A	94658921	3	1	102	1	0	0	0	0	1	0	0	0	12126	1145	40	2	3599	2	PLXNC1	12	94658921	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	37938756	94658921	39192974	138	31731										
ANO4	121601	broad.mit.edu	37	chr12	101442180	101442180	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgttttcatggcagtctgggGtaagtgttctataaccataa	10	6	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:101442180G>A	uc010svm.1	+	14	1884	c.1312_splice	c.e14+1	p.A438_splice	ANO4_uc001thw.2_Splice_Site_p.A403_splice|ANO4_uc001thx.2_Splice_Site_p.A438_splice|ANO4_uc001thy.2_Splice_Site_p.A5_splice	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4							chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GCAGTCTGGGGTAAGTGTTCT	0.373										HNSCC(74;0.22)			0	0	0	0.038395	0	13	39										A	101442180	G	A	101442180	5	1	102	1	0	0	0	0	0	0	1	0	699	1275	44	2	1254	2	ANO4	12	101442180	Splice_Site	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	6783259	101442180	32409715	139	31732										
MYBPC1	4604	broad.mit.edu	37	chr12	102069129	102069129	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tctggggagaaaatgtcgctCtcacatggactccaccaaag	10	11	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr12:102069129C>G	uc001tii.2	+	25	2950	c.2848C>G	c.(2848-2850)CTC>GTC	p.L950V	MYBPC1_uc001tig.2_Missense_Mutation_p.L957V|MYBPC1_uc010svq.1_Missense_Mutation_p.L919V|MYBPC1_uc001tih.2_Missense_Mutation_p.L957V|MYBPC1_uc001tij.2_Missense_Mutation_p.L932V|MYBPC1_uc010svr.1_Missense_Mutation_p.L932V|MYBPC1_uc010svs.1_Missense_Mutation_p.L950V|MYBPC1_uc010svt.1_Missense_Mutation_p.L920V|MYBPC1_uc010svu.1_Missense_Mutation_p.L913V|MYBPC1_uc001tik.2_Missense_Mutation_p.L906V|MYBPC1_uc001til.2_5'UTR|MYBPC1_uc001tim.2_5'UTR	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	950	Fibronectin type-III 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AAATGTCGCTCTCACATGGAC	0.478													0	0	0	0.146539	0	17	39										G	102069129	C	G	102069129	3	3	102	1	0	0	0	0	1	0	0	0	10011	913	32	1	3029	1	MYBPC1	12	102069129	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	626949	102069129	31782766	140	31733										
FREM2	341640	broad.mit.edu	37	chr13	39266378	39266378	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagacttctatgtttttcctGatacggtgtttgaaacaagg	9	7	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:39266378G>A	uc001uwv.2	+	1	5206	c.4897G>A	c.(4897-4899)GAT>AAT	p.D1633N		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1633	Extracellular (Potential).|CSPG 11.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGTTTTTCCTGATACGGTGTT	0.458													0	0	0	0.0333	0	16	42										A	39266378	G	A	39266378	3	1	102	1	0	0	0	0	1	0	0	0	6045	1290	45	1	4899	1	FREM2	13	39266378	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		39266378	75903500	141	31734										
KIAA1704	55425	broad.mit.edu	37	chr13	45580434	45580434	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaaagcaggatgattctcctCcaaggtgataatgtgtaata	9	6	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:45580434C>G	uc001uzq.2	+	3	422	c.319C>G	c.(319-321)CCA>GCA	p.P107A	KIAA1704_uc010tfo.1_RNA|KIAA1704_uc001uzr.1_Missense_Mutation_p.P107A|KIAA1704_uc001uzs.2_5'UTR|KIAA1704_uc001uzt.2_5'UTR	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425	107										pancreas(1)|skin(1)	2		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		TGATTCTCCTCCAAGGTGATA	0.279													0	0	0	0.139131	0	39	124										G	45580434	C	G	45580434	3	3	102	1	0	0	0	0	1	0	0	0	8252	855	30	1	329	1	KIAA1704	13	45580434	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	6314056	45580434	69589444	142	31735										
ATP7B	540	broad.mit.edu	37	chr13	52544680	52544680	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gacacacaggatgcacaggtCatgcctttgatctgtaagaa	10	9	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:52544680C>T	uc001vfw.2	-	3	1648	c.1491G>A	c.(1489-1491)ATG>ATA	p.M497I	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.M497I|ATP7B_uc001vfy.2_Missense_Mutation_p.M386I|ATP7B_uc010tgt.1_Missense_Mutation_p.M497I|ATP7B_uc010tgu.1_Missense_Mutation_p.M497I|ATP7B_uc010tgv.1_Missense_Mutation_p.M497I|ATP7B_uc010tgw.1_Missense_Mutation_p.M465I	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	497	HMA 5.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ATGCACAGGTCATGCCTTTGA	0.502									Wilson_disease				0	0	0	0.139131	0	63	106										T	52544680	C	T	52544680	3	4	102	1	0	0	0	0	1	0	0	0	1191	826	29	1	2982	1	ATP7B	13	52544680	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	6964246	52544680	62625198	143	31736										
MYCBP2	23077	broad.mit.edu	37	chr13	77656085	77656085	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atgaaagacgttgctctgatGaaggaactggtgatcagatt	12	5	2	6			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:77656085G>A	uc001vkf.2	-	65	11057	c.10966C>T	c.(10966-10968)CAT>TAT	p.H3656Y	MYCBP2_uc010aev.2_Missense_Mutation_p.H3060Y|MYCBP2_uc001vke.2_Missense_Mutation_p.H276Y	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTGCTCTGATGAAGGAACTGG	0.363													0	0	0	0.076483	0	23	31										A	77656085	G	A	77656085	3	1	102	1	0	0	0	0	1	0	0	0	10018	1290	45	1	3036	1	MYCBP2	13	77656085	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	25111405	77656085	37513793	144	31737										
GPC6	10082	broad.mit.edu	37	chr13	94958333	94958333	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtttcaggccctacaatcctGaggaaagaccaacaactgct	8	12	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:94958333G>C	uc001vlt.2	+	6	1740	c.1108G>C	c.(1108-1110)GAG>CAG	p.E370Q	GPC6_uc010tig.1_Missense_Mutation_p.E370Q	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	370						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CTACAATCCTGAGGAAAGACC	0.502													0	0	0	0.076483	0	19	34										C	94958333	G	C	94958333	3	2	102	1	0	0	0	0	1	0	0	0	6602	1291	45	1	1130	1	GPC6	13	94958333	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	17302248	94958333	20211545	145	31738										
RASA3	22821	broad.mit.edu	37	chr13	114758015	114758015	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaagagggagtagatacgctCcgtctcacggtccccatcaa	11	12	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr13:114758015C>T	uc001vui.2	-	22	2322	c.2191G>A	c.(2191-2193)GAG>AAG	p.E731K	RASA3_uc010tkk.1_Missense_Mutation_p.E699K|RASA3_uc001vuj.2_Missense_Mutation_p.E348K	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	731					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TAGATACGCTCCGTCTCACGG	0.527													0	0	0	0.043863	0	15	39										T	114758015	C	T	114758015	3	4	102	1	0	0	0	0	1	0	0	0	13062	864	30	1	325	1	RASA3	13	114758015	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	19799682	114758015	411863	146	31739										
RNASE13	440163	broad.mit.edu	37	chr14	21502251	21502251	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aatggatctttgggcaatctGaattttgcatcttgcctcgc	9	9	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:21502251G>A	uc001vzj.2	-	2	335	c.197C>T	c.(196-198)TCA>TTA	p.S66L	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	66						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		TGGGCAATCTGAATTTTGCAT	0.428													0	0	0	0.139131	0	44	37										A	21502251	G	A	21502251	3	1	102	1	0	0	0	0	1	0	0	0	13403	1294	45	1	277	1	RNASE13	14	21502251	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		21502251	85847289	147	31740										
TRIM9	114088	broad.mit.edu	37	chr14	51561204	51561204	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtagcggtcaattaccccttCcagtacgcgattcttgggga	11	11	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:51561204C>T	uc001wyx.3	-	1	1219	c.454G>A	c.(454-456)GAA>AAA	p.E152K	TRIM9_uc001wyy.2_Missense_Mutation_p.E152K|TRIM9_uc001wyz.3_Missense_Mutation_p.E152K	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	152					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					ATTACCCCTTCCAGTACGCGA	0.642													0	0	0	0.021553	0	4	13										T	51561204	C	T	51561204	3	4	102	1	0	0	0	0	1	0	0	0	16546	864	30	1	1768	1	TRIM9	14	51561204	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	30058953	51561204	55788336	148	31741										
DHRS7	51635	broad.mit.edu	37	chr14	60622822	60622822	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aagccagctcctcaccaattCcactcgaggctccagtcacc	6	18	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:60622822C>G	uc001xes.2	-	2	366	c.182G>C	c.(181-183)GGA>GCA	p.G61A	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Missense_Mutation_p.G11A|DHRS7_uc001xeu.2_Missense_Mutation_p.G61A	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	61	NAD (By similarity).						binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		CTCACCAATTCCACTCGAGGC	0.463													0	0	0	0.054565	0	29	47										G	60622822	C	G	60622822	3	3	102	1	0	0	0	0	1	0	0	0	4495	855	30	1	861	1	DHRS7	14	60622822	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	9061618	60622822	46726718	149	31742										
PCNX	22990	broad.mit.edu	37	chr14	71445358	71445358	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggggaagagcaagatgcagtCagtggaggtaagtaaactgt	16	4	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:71445358C>T	uc001xmo.2	+	6	2750	c.2304C>T	c.(2302-2304)GTC>GTT	p.V768V	PCNX_uc001xmn.3_Silent_p.V768V|PCNX_uc010are.1_Silent_p.V768V	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	768						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAGATGCAGTCAGTGGAGGTA	0.393													0	0	0	0.124865	0	35	45										T	71445358	C	T	71445358	2	4	102	1	0	0	0	0	0	0	0	1	11591	813	29	1		1	PCNX	14	71445358	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	10822536	71445358	35904182	150	31743										
C14orf102	55051	broad.mit.edu	37	chr14	90778760	90778760	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tgctatatcccctcggtagaGagacttgtactcccagttcg	9	12	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:90778760G>C	uc001xyi.1	-	4	566	c.535C>G	c.(535-537)CTC>GTC	p.L179V	C14orf102_uc010atp.1_5'UTR|C14orf102_uc001xyj.1_5'UTR	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	179	Potential.						protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		CCTCGGTAGAGAGACTTGTAC	0.478													0	0	0	0.092188	0	31	82										C	90778760	G	C	90778760	3	2	102	1	0	0	0	0	1	0	0	0	1735	942	33	1	3003	1	C14orf102	14	90778760	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	19333402	90778760	16570780	151	31744										
C14orf129	51527	broad.mit.edu	37	chr14	96852000	96852000	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cttcaaagactggaagctttGaaaagagatggacagtcatg	11	6	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:96852000G>C	uc001yfj.3	+	4	544	c.399G>C	c.(397-399)TTG>TTC	p.L133F	C14orf129_uc001yfl.2_Missense_Mutation_p.L133F	NM_016472	NP_057556	Q9P0R6	GSKIP_HUMAN	chromosome 14 open reading frame 129	133	Interaction with GSK3B.					cytoplasm	protein binding				0		Melanoma(154;0.226)		Epithelial(152;0.109)|COAD - Colon adenocarcinoma(157;0.205)		TGGAAGCTTTGAAAAGAGATG	0.438													0	0	0	0.139131	0	66	62										C	96852000	G	C	96852000	3	2	102	1	0	0	0	0	1	0	0	0	1744	1281	45	1	405	1	C14orf129	14	96852000	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	6073240	96852000	10497540	152	31745										
CYP46A1	10858	broad.mit.edu	37	chr14	100166436	100166436	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atagacctggccttcagccgGaggtgagtgtggccggaggc	17	10	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:100166436G>C	uc001ygo.2	+	5	441	c.441G>C	c.(439-441)CGG>CGC	p.R147R	CYP46A1_uc001ygn.1_Silent_p.R109R	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	147					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCTTCAGCCGGAGGTGAGTGT	0.622													0	0	0	0.021553	0	5	24										C	100166436	G	C	100166436	2	2	102	1	0	0	0	0	0	0	0	1	4182	1161	41	1		1	CYP46A1	14	100166436	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	3314436	100166436	7183104	153	31746										
RAGE	5891	broad.mit.edu	37	chr14	102729905	102729905	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgtattagctcataaatattCatgtccataagttcacatat	4	8	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:102729905C>T	uc001ylm.2	-	4	487	c.261G>A	c.(259-261)ATG>ATA	p.M87I	RAGE_uc010txv.1_Missense_Mutation_p.M57I|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	87	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CATAAATATTCATGTCCATAA	0.308													0	0	0	0.132662	0	10	33										T	102729905	C	T	102729905	3	4	102	1	0	0	0	0	1	0	0	0	13006	826	29	1	1034	1	RAGE	14	102729905	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2563469	102729905	4619635	154	31747										
TRAF3	7187	broad.mit.edu	37	chr14	103369714	103369714	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gagtccctccagaaccgcgtGaccgagctggagagcgtgga	15	12	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:103369714G>A	uc001ymc.1	+	11	1436	c.1083G>A	c.(1081-1083)GTG>GTA	p.V361V	TRAF3_uc001yme.1_Silent_p.V336V|TRAF3_uc001ymd.1_Silent_p.V361V|TRAF3_uc010txy.1_Silent_p.V278V|TRAF3_uc001ymf.1_Silent_p.V94V	NM_145725	NP_663777	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3 isoform 1	361					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		AGAACCGCGTGACCGAGCTGG	0.652													0	0	0	0.11126	0	37	45										A	103369714	G	A	103369714	2	1	102	1	0	0	0	0	0	0	0	1	16436	1277	45	1		1	TRAF3	14	103369714	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	639809	103369714	3979826	155	31748										
KIF26A	26153	broad.mit.edu	37	chr14	104640516	104640516	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcaccatgctgctgcgtgaaTccctggccaccgctggctgc	11	16	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:104640516T>A	uc001yos.3	+	11	2062	c.2062T>A	c.(2062-2064)TCC>ACC	p.S688T		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	688					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GCTGCGTGAATCCCTGGCCAC	0.687													0	0	0	0.021553	0	3	7										A	104640516	T	A	104640516	3	1	102	1	0	0	0	0	1	0	0	0	8294	1435	50	5	2104	5	KIF26A	14	104640516	Missense_Mutation	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	1270802	104640516	2709024	156	31749										
AHNAK2	113146	broad.mit.edu	37	chr14	105409457	105409457	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cccctccagctgcacaccatCcagctttgctctcggggcct	8	19	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr14:105409457C>T	uc010axc.1	-	7	12451	c.12331G>A	c.(12331-12333)GAT>AAT	p.D4111N	AHNAK2_uc001ypx.2_Missense_Mutation_p.D4011N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4111						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGCACACCATCCAGCTTTGCT	0.577													0	0	0	0.055883	0	17	332										T	105409457	C	T	105409457	3	4	102	1	0	0	0	0	1	0	0	0	415	855	30	1	5060	1	AHNAK2	14	105409457	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	768941	105409457	1940083	157	31750										
ATP10A	57194	broad.mit.edu	37	chr15	25959383	25959383	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gacttcagctcaaacctcacCctcacctgcaagagaaatgg	7	14	4	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:25959383C>T	uc010ayu.2	-	10	1888	c.1782G>A	c.(1780-1782)AGG>AGA	p.R594R		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	594	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CAAACCTCACCCTCACCTGCA	0.602													0	0	0	0.069288	0	19	26										T	25959383	C	T	25959383	2	4	102	1	0	0	0	0	0	0	0	1	1116	622	22	2		2	ATP10A	15	25959383	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		25959383	76572009	158	31751										
WDR72	256764	broad.mit.edu	37	chr15	54003115	54003115	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aaatggtctctttaagcactCttccatcagcagggtatatg	8	9	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr15:54003115C>T	uc002acj.2	-	9	935	c.893G>A	c.(892-894)AGA>AAA	p.R298K	WDR72_uc010bfi.1_Missense_Mutation_p.R298K	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	298										lung(1)|skin(1)	2				all cancers(107;0.0511)		TTTAAGCACTCTTCCATCAGC	0.388													0	0	0	0.045705	0	26	30										T	54003115	C	T	54003115	3	4	102	1	0	0	0	0	1	0	0	0	17319	913	32	1	2463	1	WDR72	15	54003115	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	28043732	54003115	48528277	159	31752										
MEFV	4210	broad.mit.edu	37	chr16	3294272	3294272	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	accattgaacatttccatttCtgaacgcagggtttctaaaa	6	9	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:3294272C>T	uc002cun.1	-	8	1781	c.1741G>A	c.(1741-1743)GAA>AAA	p.E581K		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	581	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	ATTTCCATTTCTGAACGCAGG	0.522													0	0	0	0.116897	0	24	26										T	3294272	C	T	3294272	3	4	102	1	0	0	0	0	1	0	0	0	9459	922	32	1	616	1	MEFV	16	3294272	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		3294272	87060481	160	31753										
CLEC16A	23274	broad.mit.edu	37	chr16	11076791	11076791	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcgttagctgaagtcattctGaatggtgatctgtctgagat	11	6	4	4			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:11076791G>T	uc002dao.2	+	10	1244	c.1014G>T	c.(1012-1014)CTG>CTT	p.L338L	CLEC16A_uc002dan.3_Silent_p.L336L	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	338										ovary(1)|central_nervous_system(1)	2						AAGTCATTCTGAATGGTGATC	0.428													1	0	4.36969e-10	0.105934	4.65001e-10	10	39										T	11076791	G	T	11076791	2	4	102	1	0	0	0	0	0	0	0	1	3500	1277	45	3		3	CLEC16A	16	11076791	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	7782519	11076791	79277962	161	31754										
ABCC1	4363	broad.mit.edu	37	chr16	16180769	16180769	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	catttacctcttcgatgatcCcctctcagcagtggatgccc	7	15	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:16180769C>T	uc010bvi.2	+	18	2556	c.2381C>T	c.(2380-2382)CCC>CTC	p.P794L	ABCC1_uc010bvj.2_Missense_Mutation_p.P735L|ABCC1_uc010bvk.2_Intron|ABCC1_uc010bvl.2_Missense_Mutation_p.P794L|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_Missense_Mutation_p.P678L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	794	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TTCGATGATCCCCTCTCAGCA	0.597													0	0	0	0.049695	0	18	59										T	16180769	C	T	16180769	3	4	102	1	0	0	0	0	1	0	0	0	49	623	22	2	2451	2	ABCC1	16	16180769	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	5103978	16180769	74173984	162	31755										
UMOD	7369	broad.mit.edu	37	chr16	20344666	20344666	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtcagggtcaaggtggccgaGagaagcagaggcagccagac	17	9	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:20344666G>T	uc002dgz.2	-	11	2022	c.1893C>A	c.(1891-1893)CTC>CTA	p.L631L	UMOD_uc002dha.2_Silent_p.L631L|UMOD_uc002dhb.2_Silent_p.L664L	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	631					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						AGGTGGCCGAGAGAAGCAGAG	0.542													1	0	0.000274275	0.047766	0.000281257	6	30										T	20344666	G	T	20344666	2	4	102	1	0	0	0	0	0	0	0	1	16976	929	33	3		3	UMOD	16	20344666	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	4163897	20344666	70010087	163	31756										
ACSM5	54988	broad.mit.edu	37	chr16	20441100	20441100	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agactggtgtggagctgtacGaaggctatggccagtctgaa	15	7	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:20441100G>A	uc002dhe.2	+	8	1249	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	368	ATP (By similarity).				fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GGAGCTGTACGAAGGCTATGG	0.617													0	0	0	0.11911	0	11	51										A	20441100	G	A	20441100	3	1	102	1	0	0	0	0	1	0	0	0	187	1059	37	1	1128	1	ACSM5	16	20441100	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	96434	20441100	69913653	164	31757										
CDH1	999	broad.mit.edu	37	chr16	68863653	68863653	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcatgagtgtcccccggtatCttccccgccctgccaatccc	7	19	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:68863653C>G	uc002ewg.1	+	15	2516	c.2392C>G	c.(2392-2394)CTT>GTT	p.L798V	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.L737V	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	798	Cytoplasmic (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CCCCCGGTATCTTCCCCGCCC	0.522			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.0918	0	19	80										G	68863653	C	G	68863653	3	3	102	1	0	0	0	0	1	0	0	0	3095	913	32	1	2450	1	CDH1	16	68863653	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	48422553	68863653	21491100	165	31758										
MPHOSPH6	10200	broad.mit.edu	37	chr16	82183009	82183009	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttcatctgaagcatcaatttCtgaaaaatacaccagtgctg	6	9	4	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:82183009C>A	uc002fgw.2	-	4	305	c.256_splice	c.e4-1	p.K86_splice		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6						M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						GCATCAATTTCTGAAAAATAC	0.398													1	0	1.90571e-15	0.069456	2.07494e-15	34	35										A	82183009	C	A	82183009	5	1	102	1	0	0	0	0	0	0	1	0	9726	927	32	3	235	3	MPHOSPH6	16	82183009	Splice_Site	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	13319356	82183009	8171744	166	31759										
KLHDC4	54758	broad.mit.edu	37	chr16	87760397	87760397	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgagtagcccccatagacgaCgatgccgccctggggagtga	14	13	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:87760397C>T	uc002fki.2	-	7	779	c.733G>A	c.(733-735)GTC>ATC	p.V245I	KLHDC4_uc010cht.1_Missense_Mutation_p.V64I|KLHDC4_uc002fkj.2_Missense_Mutation_p.V214I|KLHDC4_uc002fkk.2_Missense_Mutation_p.V64I|KLHDC4_uc002fkl.2_Missense_Mutation_p.V188I|KLHDC4_uc010chu.1_Missense_Mutation_p.V64I	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	245	Kelch 4.									pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CCATAGACGACGATGCCGCCC	0.652													0	0	0	0.049695	0	15	30										T	87760397	C	T	87760397	3	4	102	1	0	0	0	0	1	0	0	0	8358	536	19	2	849	2	KLHDC4	16	87760397	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	5577388	87760397	2594356	167	31760										
ANKRD11	29123	broad.mit.edu	37	chr16	89351818	89351818	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gggtatagagataaaactatTggatttcgtttcttttctgt	9	4	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr16:89351818T>C	uc002fmx.1	-	9	1593	c.1132A>G	c.(1132-1134)AAT>GAT	p.N378D	ANKRD11_uc002fmy.1_Missense_Mutation_p.N378D|ANKRD11_uc002fnc.1_Missense_Mutation_p.N378D|ANKRD11_uc002fnb.1_Missense_Mutation_p.N335D	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	378						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		ATAAAACTATTGGATTTCGTT	0.433													0	0	0	0.050027	0	27	55										C	89351818	T	C	89351818	3	2	102	1	0	0	0	0	1	0	0	0	639	1812	63	5	6879	5	ANKRD11	16	89351818	Missense_Mutation	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	1591421	89351818	1002935	168	31761										
SPATA22	84690	broad.mit.edu	37	chr17	3352316	3352316	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcttaattgtttttgttgttGagctcccgaactcactggac	8	9	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:3352316G>C	uc002fvm.2	-	6	694	c.457C>G	c.(457-459)CAA>GAA	p.Q153E	SPATA22_uc010vrg.1_Missense_Mutation_p.Q137E|SPATA22_uc010vrf.1_Missense_Mutation_p.Q153E|SPATA22_uc002fvn.2_Missense_Mutation_p.Q153E|SPATA22_uc002fvo.2_Missense_Mutation_p.Q153E|SPATA22_uc002fvp.2_Missense_Mutation_p.Q153E|SPATA22_uc010ckf.2_Missense_Mutation_p.Q110E	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	153											0						TTTTGTTGTTGAGCTCCCGAA	0.358													0	0	0	0.092188	0	35	83										C	3352316	G	C	3352316	3	2	102	1	0	0	0	0	1	0	0	0	15007	1299	45	1	650	1	SPATA22	17	3352316	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		3352316	77842894	169	31762										
KIF1C	10749	broad.mit.edu	37	chr17	4905368	4905368	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctccagctctgtgaggacctCttctctcgcgttagtgagaa	10	12	3	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:4905368C>G	uc002gan.1	+	6	704	c.378C>G	c.(376-378)CTC>CTG	p.L126L		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	126	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GTGAGGACCTCTTCTCTCGCG	0.413													0	0	0	0.117977	0	34	48										G	4905368	C	G	4905368	2	3	102	1	0	0	0	0	0	0	0	1	8285	900	32	1		1	KIF1C	17	4905368	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1553052	4905368	76289842	170	31763										
DNAH2	146754	broad.mit.edu	37	chr17	7722612	7722612	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgaccccatgtaccagttctCactggatgcctacatcagcc	7	16	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:7722612C>T	uc002giu.1	+	71	10915	c.10901C>T	c.(10900-10902)TCA>TTA	p.S3634L	DNAH2_uc010cnm.1_Missense_Mutation_p.S572L	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3634					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACCAGTTCTCACTGGATGCC	0.542													0	0	0	0.132662	0	14	47										T	7722612	C	T	7722612	3	4	102	1	0	0	0	0	1	0	0	0	4602	838	29	1	11183	1	DNAH2	17	7722612	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2817244	7722612	73472598	171	31764										
FAM83G	644815	broad.mit.edu	37	chr17	18907093	18907093	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cccattgtcctcgggcccctGagaggggcccgtgccccgag	14	17	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:18907093G>A	uc002guw.2	-	2	429	c.262C>T	c.(262-264)CAG>TAG	p.Q88*	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	88										ovary(1)|central_nervous_system(1)	2						TCGGGCCCCTGAGAGGGGCCC	0.701													0	0	0	0.009096	0	4	4										A	18907093	G	A	18907093	4	1	102	1	0	0	0	0	0	1	0	0	5639	1299	45	1	2229	1	FAM83G	17	18907093	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	11184481	18907093	62288117	172	31765										
PIGS	94005	broad.mit.edu	37	chr17	26890869	26890869	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgatgacagggcctcctcctCatggtccaaagccctccgat	9	16	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:26890869C>T	uc002hbo.2	-	4	716	c.343G>A	c.(343-345)GAG>AAG	p.E115K	PIGS_uc002hbn.2_Missense_Mutation_p.E107K|PIGS_uc010wap.1_Missense_Mutation_p.E54K	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	115	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					GCCTCCTCCTCATGGTCCAAA	0.478													0	0	0	0.139131	0	43	130										T	26890869	C	T	26890869	3	4	102	1	0	0	0	0	1	0	0	0	11898	835	29	1	1360	1	PIGS	17	26890869	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	7983776	26890869	54304341	173	31766										
ANKRD13B	124930	broad.mit.edu	37	chr17	27935029	27935029	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	caggaggctgtgagtacccgGgacctggagctggtgcagct	17	10	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:27935029G>A	uc002hei.2	+	3	389	c.276G>A	c.(274-276)CGG>CGA	p.R92R	ANKRD13B_uc002heh.2_Intron|ANKRD13B_uc002hej.2_RNA	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	92	ANK 2.										0						TGAGTACCCGGGACCTGGAGC	0.667													0	0	0	0.105934	0	11	27										A	27935029	G	A	27935029	2	1	102	1	0	0	0	0	0	0	0	1	642	1219	43	2		2	ANKRD13B	17	27935029	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1044160	27935029	53260181	174	31767										
ATAD5	79915	broad.mit.edu	37	chr17	29162311	29162311	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaagaaagacagcaatttatGaaagcatttaggcagccagc	10	7	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162311G>A	uc002hfs.1	+	2	1558	c.1212G>A	c.(1210-1212)ATG>ATA	p.M404I	ATAD5_uc002hft.1_Missense_Mutation_p.M301I	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	404					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCAATTTATGAAAGCATTTA	0.358													0	0	0	0.09319	0	12	44										A	29162311	G	A	29162311	3	1	102	1	0	0	0	0	1	0	0	0	1076	1290	45	1	1218	1	ATAD5	17	29162311	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1227282	29162311	52032899	175	31768			1	143		3	3	533	G		7.508645e-06
ATAD5	79915	broad.mit.edu	37	chr17	29162605	29162605	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agagagggaaacactcaaaaGaaagaaacaacctttttctt	7	7	2	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162605G>C	uc002hfs.1	+	2	1852	c.1506G>C	c.(1504-1506)AAG>AAC	p.K502N	ATAD5_uc002hft.1_Missense_Mutation_p.K399N	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	502					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ACACTCAAAAGAAAGAAACAA	0.303													0	0	0	0.105934	0	12	33										C	29162605	G	C	29162605	3	2	102	1	0	0	0	0	1	0	0	0	1076	933	33	1	1512	1	ATAD5	17	29162605	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	294	29162605	52032605	176	31769			1	143		3	3	533	G		7.508645e-06
ATAD5	79915	broad.mit.edu	37	chr17	29162843	29162843	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cacagtctaaagctgaatctGaagccagcttgctaaatgtt	8	9	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29162843G>A	uc002hfs.1	+	2	2090	c.1744G>A	c.(1744-1746)GAA>AAA	p.E582K	ATAD5_uc002hft.1_Missense_Mutation_p.E479K	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	582					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCTGAATCTGAAGCCAGCTT	0.378													0	0	0	0.0333	0	15	55										A	29162843	G	A	29162843	3	1	102	1	0	0	0	0	1	0	0	0	1076	1291	45	1	1750	1	ATAD5	17	29162843	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	238	29162843	52032367	177	31770			1	143		3	3	533	G		7.508645e-06
NF1	4763	broad.mit.edu	37	chr17	29533336	29533336	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaaatatgtttggtgaaacaCttcataaagcagtgcaaggt	10	5	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29533336C>T	uc002hgg.2	+	12	1672	c.1339C>T	c.(1339-1341)CTT>TTT	p.L447F	NF1_uc002hge.1_Missense_Mutation_p.L447F|NF1_uc002hgf.1_Missense_Mutation_p.L447F|NF1_uc002hgh.2_Missense_Mutation_p.L447F|NF1_uc010csn.1_Missense_Mutation_p.L307F	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	447					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGGTGAAACACTTCATAAAGC	0.413			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.139131	0	40	90										T	29533336	C	T	29533336	3	4	102	1	0	0	0	0	1	0	0	0	10356	565	20	2	1385	2	NF1	17	29533336	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	370493	29533336	51661874	178	31771										
NF1	4763	broad.mit.edu	37	chr17	29557904	29557904	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	agactgggttatgggaacatCaaaccaagcagcagatgatg	12	7	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:29557904C>G	uc002hgg.2	+	24	3491	c.3158C>G	c.(3157-3159)TCA>TGA	p.S1053*	NF1_uc002hgh.2_Nonsense_Mutation_p.S1053*|NF1_uc010csn.1_Nonsense_Mutation_p.S913*|NF1_uc002hgi.1_Nonsense_Mutation_p.S86*	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1053					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ATGGGAACATCAAACCAAGCA	0.358			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.02938	0	4	12										G	29557904	C	G	29557904	4	3	102	1	0	0	0	0	0	1	0	0	10356	838	29	1	3313	1	NF1	17	29557904	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	24568	29557904	51637306	179	31772										
SPACA3	124912	broad.mit.edu	37	chr17	31322626	31322626	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttggccctggtctgtctgctCagctgcctgctaccctccag	10	16	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:31322626C>T	uc002hhs.1	+	2	309	c.234C>T	c.(232-234)CTC>CTT	p.L78L	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	78	Helical; Signal-anchor for type II membrane protein; (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			TCTGTCTGCTCAGCTGCCTGC	0.622													0	0	0	0.038395	0	17	47										T	31322626	C	T	31322626	2	4	102	1	0	0	0	0	0	0	0	1	14973	813	29	1		1	SPACA3	17	31322626	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1764722	31322626	49872584	180	31773										
TUBG1	7283	broad.mit.edu	37	chr17	40762134	40762134	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccttccccccagttgggttcGagttctggaaacagctgtgc	11	13	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:40762134G>C	uc002ian.2	+	2	456	c.58G>C	c.(58-60)GAG>CAG	p.E20Q	FAM134C_uc002ial.2_5'Flank|FAM134C_uc010wgq.1_5'Flank|FAM134C_uc002iam.1_5'Flank|FAM134C_uc010cyk.1_Intron	NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	20					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		AGTTGGGTTCGAGTTCTGGAA	0.627													0	0	0	0.054565	0	30	59										C	40762134	G	C	40762134	3	2	102	1	0	0	0	0	1	0	0	0	16761	1059	37	1	64	1	TUBG1	17	40762134	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	9439508	40762134	40433076	181	31774										
BECN1	8678	broad.mit.edu	37	chr17	40963765	40963765	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gccaccattgcatggtcaaaCttgttgtcccagaaaaaccg	8	12	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:40963765C>G	uc002ibo.3	-	11	1227	c.1092G>C	c.(1090-1092)AAG>AAC	p.K364N	BECN1_uc010whb.1_Missense_Mutation_p.K277N|BECN1_uc010whc.1_Intron|BECN1_uc002ibn.2_Missense_Mutation_p.K364N	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	364					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		CATGGTCAAACTTGTTGTCCC	0.493													0	0	0	0.059317	0	29	64										G	40963765	C	G	40963765	3	3	102	1	0	0	0	0	1	0	0	0	1396	564	20	4	268	4	BECN1	17	40963765	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	201631	40963765	40231445	182	31775										
MPP2	4355	broad.mit.edu	37	chr17	41958843	41958843	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cacctgccaccagttggcatCatcctggtttacgatctgga	9	13	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:41958843C>A	uc010wip.1	-	7	988	c.931G>T	c.(931-933)GAT>TAT	p.D311Y	MPP2_uc002ien.1_Missense_Mutation_p.D283Y|MPP2_uc010wim.1_Missense_Mutation_p.D255Y|MPP2_uc002ieo.1_Missense_Mutation_p.D266Y|MPP2_uc010win.1_Missense_Mutation_p.D127Y|MPP2_uc010wio.1_Missense_Mutation_p.D255Y	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	290	SH3.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CAGTTGGCATCATCCTGGTTT	0.627													1	0	1.30916e-28	0.139131	1.45348e-28	37	75										A	41958843	C	A	41958843	3	1	102	1	0	0	0	0	1	0	0	0	9734	826	29	3	890	3	MPP2	17	41958843	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	995078	41958843	39236367	183	31776										
ACE	1636	broad.mit.edu	37	chr17	61566090	61566090	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctggcgagacaaggcggggaGagccatcctccagttttacc	13	12	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:61566090G>C	uc002jau.1	+	16	2409	c.2387G>C	c.(2386-2388)AGA>ACA	p.R796T	ACE_uc002jav.1_Missense_Mutation_p.R222T|ACE_uc010ddv.1_Missense_Mutation_p.R23T|ACE_uc010wpj.1_Missense_Mutation_p.R222T|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.R106T	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	796	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AAGGCGGGGAGAGCCATCCTC	0.562													0	0	0	0.064281	0	30	45										C	61566090	G	C	61566090	3	2	102	1	0	0	0	0	1	0	0	0	136	942	33	1	2652	1	ACE	17	61566090	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	19607247	61566090	19629120	184	31777										
HELZ	9931	broad.mit.edu	37	chr17	65141908	65141908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttttttcttgtacatcttctCctcgtgctgtaaagaaagtt	6	8	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:65141908C>T	uc010wqk.1	-	21	2910	c.2723G>A	c.(2722-2724)GGA>GAA	p.G908E	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.G907E	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TACATCTTCTCCTCGTGCTGT	0.378													0	0	0	0.047766	0	8	38										T	65141908	C	T	65141908	3	4	102	1	0	0	0	0	1	0	0	0	7049	855	30	1	3160	1	HELZ	17	65141908	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	3575818	65141908	16053302	185	31778										
KCNJ2	3759	broad.mit.edu	37	chr17	68171221	68171221	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccgctacagcatcgtctcttCagaagaagacggtatgaagt	10	10	2	4			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr17:68171221C>T	uc010dfg.2	+	2	442	c.41C>T	c.(40-42)TCA>TTA	p.S14L	KCNJ2_uc002jir.2_Missense_Mutation_p.S14L	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	14	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					ATCGTCTCTTCAGAAGAAGAC	0.517													0	0	0	0.0918	0	19	22										T	68171221	C	T	68171221	3	4	102	1	0	0	0	0	1	0	0	0	8051	838	29	1	43	1	KCNJ2	17	68171221	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	3029313	68171221	13023989	186	31779										
EPB41L3	23136	broad.mit.edu	37	chr18	5394743	5394743	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggaccactactttggtcactGacatgtcagggtgctgctct	11	11	3	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:5394743G>A	uc002kmt.1	-	22	3289	c.3203C>T	c.(3202-3204)TCA>TTA	p.S1068L	EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Missense_Mutation_p.S846L|EPB41L3_uc010dkq.1_Missense_Mutation_p.S737L|EPB41L3_uc002kms.1_Missense_Mutation_p.S303L|EPB41L3_uc010wze.1_Missense_Mutation_p.S373L|EPB41L3_uc010wzf.1_Missense_Mutation_p.S365L|EPB41L3_uc010wzg.1_Missense_Mutation_p.S340L|EPB41L3_uc010dkr.2_Missense_Mutation_p.S460L	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1068	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTTGGTCACTGACATGTCAGG	0.502													0	0	0	0.099896	0	24	74										A	5394743	G	A	5394743	3	1	102	1	0	0	0	0	1	0	0	0	5154	1294	45	1	64	1	EPB41L3	18	5394743	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		5394743	72682505	187	31780										
SYT4	6860	broad.mit.edu	37	chr18	40854029	40854029	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cttctaaaaagagcttcgggGttgcattctccagatcagaa	9	9	3	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:40854029G>T	uc002law.2	-	2	734	c.365C>A	c.(364-366)ACC>AAC	p.T122N	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.T104N|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	122	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						GAGCTTCGGGGTTGCATTCTC	0.433													1	0	9.78306e-22	0.144211	1.08189e-21	22	49										T	40854029	G	T	40854029	3	4	102	1	0	0	0	0	1	0	0	0	15473	1261	44	4	924	4	SYT4	18	40854029	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	35459286	40854029	37223219	188	31781										
CCDC102B	79839	broad.mit.edu	37	chr18	66504371	66504371	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggaggaaggaagacaactcaGaataaaactagagatggcga	13	5	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr18:66504371G>A	uc002lkk.2	+	4	594	c.371G>A	c.(370-372)AGA>AAA	p.R124K	CCDC102B_uc002lki.2_Missense_Mutation_p.R124K|CCDC102B_uc002lkj.1_Missense_Mutation_p.R124K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	124	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGACAACTCAGAATAAAACTA	0.458													0	0	0	0.069288	0	18	29										A	66504371	G	A	66504371	3	1	102	1	0	0	0	0	1	0	0	0	2737	942	33	1	373	1	CCDC102B	18	66504371	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	25650342	66504371	11572877	189	31782										
TJP3	27134	broad.mit.edu	37	chr19	3735874	3735874	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ttttccctttcagagttgccCagggaaagcagctatgacat	9	10	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:3735874C>G	uc010xhv.1	+	9	1167	c.1167C>G	c.(1165-1167)CCC>CCG	p.P389P	TJP3_uc010xhs.1_Silent_p.P356P|TJP3_uc010xht.1_Silent_p.P320P|TJP3_uc010xhu.1_Silent_p.P365P|TJP3_uc010xhw.1_Silent_p.P375P	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	370						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGAGTTGCCCAGGGAAAGCA	0.512													0	0	0	0.139131	0	40	92										G	3735874	C	G	3735874	2	3	102	1	0	0	0	0	0	0	0	1	15928	581	21	4		4	TJP3	19	3735874	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		3735874	55393109	190	31783										
DNMT1	1786	broad.mit.edu	37	chr19	10270402	10270402	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccagactcgttggcatcaaaGatggacagcttctcatttgt	9	10	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:10270402G>C	uc002mng.2	-	16	1344	c.1164C>G	c.(1162-1164)ATC>ATG	p.I388M	DNMT1_uc010xlc.1_Missense_Mutation_p.I404M|DNMT1_uc002mnh.2_Missense_Mutation_p.I283M|DNMT1_uc010xld.1_Missense_Mutation_p.I388M	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	388	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TGGCATCAAAGATGGACAGCT	0.537													0	0	0	0.049695	0	18	60										C	10270402	G	C	10270402	3	2	102	1	0	0	0	0	1	0	0	0	4675	932	33	1	3786	1	DNMT1	19	10270402	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	6534528	10270402	48858581	191	31784										
ZNF491	126069	broad.mit.edu	37	chr19	11916930	11916930	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggatattcatcctttaatagGaacatcagaactgacactgg	8	8	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:11916930G>C	uc002mso.1	+	3	447	c.162G>C	c.(160-162)AGG>AGC	p.R54S		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	54	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCTTTAATAGGAACATCAGAA	0.393													0	0	0	0.043863	0	16	31										C	11916930	G	C	11916930	3	2	102	1	0	0	0	0	1	0	0	0	17939	1165	41	1	164	1	ZNF491	19	11916930	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1646528	11916930	47212053	192	31785										
ZNF443	10224	broad.mit.edu	37	chr19	12542302	12542302	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaaaaggctttagaacactgCttacattcatatggtttctc	7	8	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:12542302C>T	uc002mtu.2	-	4	882	c.684G>A	c.(682-684)AAG>AAA	p.K228K		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	228	C2H2-type 4.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TAGAACACTGCTTACATTCAT	0.373													0	0	0	0.02938	0	6	123										T	12542302	C	T	12542302	2	4	102	1	0	0	0	0	0	0	0	1	17913	796	28	2		2	ZNF443	19	12542302	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	625372	12542302	46586681	193	31786										
ZNF737	100129842	broad.mit.edu	37	chr19	20727612	20727612	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tcttatgtgcagtaaggtgtGaggacgagttgaaggctttg	15	4	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:20727612G>C	uc002npa.2	-	4	1577	c.1397C>G	c.(1396-1398)TCA>TGA	p.S466*		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	466					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGTAAGGTGTGAGGACGAGTT	0.413													0	0	0	0.064281	0	31	54										C	20727612	G	C	20727612	4	2	102	1	0	0	0	0	0	1	0	0	18123	1294	45	1	217	1	ZNF737	19	20727612	Nonsense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	8185310	20727612	38401371	194	31787										
SPRED3	399473	broad.mit.edu	37	chr19	38881044	38881044	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	caggtgagcgtgtgtcgggtCcgaggggccaggcccgaggg	21	10	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:38881044C>T	uc002oim.2	+	1	106	c.102C>T	c.(100-102)GTC>GTT	p.V34V	GGN_uc002oij.1_5'Flank|GGN_uc002oik.1_5'Flank|GGN_uc010efy.1_5'Flank|SPRED3_uc002oil.1_Silent_p.V34V	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	34	WH1.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTGTCGGGTCCGAGGGGCCA	0.731													0	0	0	0.009096	0	4	8										T	38881044	C	T	38881044	2	4	102	1	0	0	0	0	0	0	0	1	15093	842	30	1		1	SPRED3	19	38881044	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	18153432	38881044	20247939	195	31788										
SERTAD1	29950	broad.mit.edu	37	chr19	40928872	40928872	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccatcctcagggcctggtttGaggccctcagaggctggtgc	14	13	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:40928872G>C	uc002ont.3	-	2	741	c.582C>G	c.(580-582)CTC>CTG	p.L194L		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	194					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCCTGGTTTGAGGCCCTCAG	0.582													0	0	0	0.009096	0	4	6										C	40928872	G	C	40928872	2	2	102	1	0	0	0	0	0	0	0	1	14120	1277	45	1		1	SERTAD1	19	40928872	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	2047828	40928872	18200111	196	31789										
CYP2B6	1555	broad.mit.edu	37	chr19	41518309	41518309	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcagtcatctatgagattcaGagattttccgaccttctccc	7	12	4	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:41518309G>C	uc002opr.1	+	7	1078	c.1071G>C	c.(1069-1071)CAG>CAC	p.Q357H	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.Q157H	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	357					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	ATGAGATTCAGAGATTTTCCG	0.537													0	0	0	0.045705	0	26	45										C	41518309	G	C	41518309	3	2	102	1	0	0	0	0	1	0	0	0	4164	933	33	1	1097	1	CYP2B6	19	41518309	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	589437	41518309	17610674	197	31790										
C19orf73	55150	broad.mit.edu	37	chr19	49622031	49622031	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagagtcctgaaacgcagccGgagccagtgggcggcctctg	15	13	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:49622031G>A	uc002pmq.3	-	1	367	c.249C>T	c.(247-249)TCC>TCT	p.S83S	PPFIA3_uc002pmr.2_5'Flank|PPFIA3_uc010yai.1_5'Flank	NM_018111	NP_060581	Q9NVV2	CS073_HUMAN	hypothetical protein LOC55150	83										large_intestine(1)	1						AAACGCAGCCGGAGCCAGTGG	0.657													0	0	0	0.009096	0	3	83										A	49622031	G	A	49622031	2	1	102	1	0	0	0	0	0	0	0	1	1948	1103	39	2		2	C19orf73	19	49622031	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	8103722	49622031	9506952	198	31791										
KLK6	5653	broad.mit.edu	37	chr19	51470539	51470539	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aggggtgagatgtcttgtcgCagggtccgccatgcaccaac	14	11	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:51470539C>T	uc002pui.2	-	4	343	c.83G>A	c.(82-84)TGC>TAC	p.C28Y	KLK6_uc010eoj.2_Missense_Mutation_p.C28Y|KLK6_uc002puh.2_Missense_Mutation_p.C37Y|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Missense_Mutation_p.C28Y|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	28	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TGTCTTGTCGCAGGGTCCGCC	0.587													0	0	0	0.105934	0	10	25										T	51470539	C	T	51470539	3	4	102	1	0	0	0	0	1	0	0	0	8408	710	25	2	667	2	KLK6	19	51470539	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	1848508	51470539	7658444	199	31792										
ZNF761	388561	broad.mit.edu	37	chr19	53958360	53958360	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaataatttctggaattcttCattactcacacaaaaacagg	5	8	4	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:53958360C>A	uc010eqp.2	+	7	1057	c.599C>A	c.(598-600)TCA>TAA	p.S200*	ZNF761_uc010ydy.1_Nonsense_Mutation_p.S146*|ZNF761_uc002qbt.1_Nonsense_Mutation_p.S146*	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S146*(1)		ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TGGAATTCTTCATTACTCACA	0.373													1	0	2.46105e-21	0.045705	2.711e-21	31	62										A	53958360	C	A	53958360	4	1	102	1	0	0	0	0	0	1	0	0	18133	838	29	3	610	3	ZNF761	19	53958360	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2487821	53958360	5170623	200	31793										
LILRA3	11026	broad.mit.edu	37	chr19	54803053	54803053	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aggagatcactgggtagagaCcacacatagggagcgcgcga	15	9	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:54803053C>T	uc002qfd.2	-	4	689	c.624G>A	c.(622-624)TGG>TGA	p.W208*	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	208	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGTAGAGACCACACATAGG	0.617													0	0	0	0.064281	0	30	27										T	54803053	C	T	54803053	4	4	102	1	0	0	0	0	0	1	0	0	8786	508	18	2	711	2	LILRA3	19	54803053	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	844693	54803053	4325930	201	31794										
NLRP2	55655	broad.mit.edu	37	chr19	55494608	55494608	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagtttctcactgccctgttCtacaccctggagaaggagga	10	12	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:55494608C>G	uc002qij.2	+	6	1628	c.1542C>G	c.(1540-1542)TTC>TTG	p.F514L	NLRP2_uc010yfp.1_Missense_Mutation_p.F491L|NLRP2_uc010esn.2_Missense_Mutation_p.F490L|NLRP2_uc010eso.2_Missense_Mutation_p.F511L|NLRP2_uc010esp.2_Missense_Mutation_p.F492L	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	514	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTGCCCTGTTCTACACCCTGG	0.562													0	0	0	0.080422	0	31	49										G	55494608	C	G	55494608	3	3	102	1	0	0	0	0	1	0	0	0	10477	912	32	1	1560	1	NLRP2	19	55494608	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	691555	55494608	3634375	202	31795										
A1BG	1	broad.mit.edu	37	chr19	58863655	58863655	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gttcccacagtcaccgagctCctcaatggtcacagtagcgc	9	15	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr19:58863655C>G	uc002qsd.3	-	4	669	c.607G>C	c.(607-609)GAG>CAG	p.E203Q	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	203	Ig-like V-type 2.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		TCACCGAGCTCCTCAATGGTC	0.607													0	0	0	0.069288	0	19	38										G	58863655	C	G	58863655	3	3	102	1	0	0	0	0	1	0	0	0	1	864	30	1	900	1	A1BG	19	58863655	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	3369047	58863655	265328	203	31796										
SCRT2	85508	broad.mit.edu	37	chr20	644846	644847	+	Frame_Shift_Ins	INS	-	-	C													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgccccccgcgtctcccgagINSccccccgcgtccccgccgcc							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:644846_644847insC	uc002wec.2	-	2	970_971	c.392_393insG	c.(391-393)GGCfs	p.G131fs	SRXN1_uc002web.2_Intron	NM_033129	NP_149120	Q9NQ03	SCRT2_HUMAN	scratch 2 protein	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						cgtctcccgagccccccgcgtc	0.347																		2	4	---	---								C	644847	-	C	644846	7	5	102	1	0	1	1	0	0	0	0	0	13942	958	34	0	534	0	SCRT2	20	644846	Frame_Shift_Ins	INS	-	TCGA-GC-A3I6-01A-11D-A20D-08		644846	62380674	204	31797										
JAG1	182	broad.mit.edu	37	chr20	10621880	10621880	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	caattcactgcaaatgtgctCcgtagtaagaccctaaaacg	7	11	1	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:10621880C>G	uc002wnw.2	-	24	3445	c.2929G>C	c.(2929-2931)GAG>CAG	p.E977Q		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	977	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						CAAATGTGCTCCGTAGTAAGA	0.408									Alagille_Syndrome				0	0	0	0.014758	0	4	62										G	10621880	C	G	10621880	3	3	102	1	0	0	0	0	1	0	0	0	7934	864	30	1	739	1	JAG1	20	10621880	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	9977034	10621880	52403640	205	31798										
BCL2L1	598	broad.mit.edu	37	chr20	30309591	30309591	+	Frame_Shift_Del	DEL	A	A	-													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	acagtgccccgccgaaggagAaaaaggccacaatgcgaccc							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:30309591delA	uc002wwl.2	-	2	797	c.431delT	c.(430-432)TTCfs	p.F144fs	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Intron|BCL2L1_uc002wwn.2_Frame_Shift_Del_p.F144fs|BCL2L1_uc002wwo.1_Frame_Shift_Del_p.F144fs	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	144	BH1.				induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542																		7	1557	---	---								-	30309591	A	-	30309591	7	5	102	1	0	1	0	1	0	0	0	0	1367	246	9	0	278	0	BCL2L1	20	30309591	Frame_Shift_Del	DEL	A	TCGA-GC-A3I6-01A-11D-A20D-08	19687711	30309591	32715929	206	31799										
CHD6	84181	broad.mit.edu	37	chr20	40050336	40050336	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctctgaagtcctactcatttGagaatatgtaagagattcat	7	7	3	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr20:40050336G>C	uc002xka.1	-	31	5117	c.4939C>G	c.(4939-4941)CAA>GAA	p.Q1647E		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1647					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CTACTCATTTGAGAATATGTA	0.423													0	0	0	0.105934	0	12	26										C	40050336	G	C	40050336	3	2	102	1	0	0	0	0	1	0	0	0	3329	1299	45	1	3236	1	CHD6	20	40050336	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	9740745	40050336	22975184	207	31800										
BTG3	10950	broad.mit.edu	37	chr21	18977218	18977218	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gtccacccagagagtgagctCctttggcaagcccaggtcac	11	14	1	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:18977218C>A	uc002ykk.2	-	3	531	c.271G>T	c.(271-273)GAG>TAG	p.E91*	BTG3_uc002ykl.2_Nonsense_Mutation_p.E91*	NM_006806	NP_006797	Q14201	BTG3_HUMAN	B-cell translocation gene 3 isoform b	91					negative regulation of cell proliferation|negative regulation of mitotic cell cycle	cytoplasm					0				Epithelial(23;0.000283)|all cancers(11;0.0012)|Lung(58;0.0191)|OV - Ovarian serous cystadenocarcinoma(11;0.0206)|COAD - Colon adenocarcinoma(22;0.0315)|LUSC - Lung squamous cell carcinoma(23;0.0703)|Colorectal(24;0.0971)		AGAGTGAGCTCCTTTGGCAAG	0.448													1	0	2.39187e-15	0.049695	2.59426e-15	19	26										A	18977218	C	A	18977218	4	1	102	1	0	0	0	0	0	1	0	0	1555	864	30	3	635	3	BTG3	21	18977218	Nonsense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		18977218	29152677	208	31801										
GABPA	2551	broad.mit.edu	37	chr21	27130452	27130452	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tatgtagtctcaaccaagaaGatttttttcagcgggttcct	8	8	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:27130452G>T	uc002ylx.3	+	6	1212	c.685G>T	c.(685-687)GAT>TAT	p.D229Y	GABPA_uc002yly.3_Missense_Mutation_p.D229Y	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	229	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						CAACCAAGAAGATTTTTTTCA	0.398													1	0	8.10497e-08	0.055883	8.49666e-08	16	42										T	27130452	G	T	27130452	3	4	102	1	0	0	0	0	1	0	0	0	6157	942	33	3	703	3	GABPA	21	27130452	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	8153234	27130452	20999443	209	31802										
AGPAT3	56894	broad.mit.edu	37	chr21	45387862	45387862	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tggagtggtggtcctgcacgGagtgtacactgttcacggac	15	9	1	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45387862G>C	uc002zdv.2	+	4	436	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	AGPAT3_uc002zdw.2_Missense_Mutation_p.E72Q|AGPAT3_uc002zdx.2_Missense_Mutation_p.E159Q|AGPAT3_uc002zdy.2_Missense_Mutation_p.E10Q	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	72	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		GTCCTGCACGGAGTGTACACT	0.612													0	0	0	0.047766	0	8	26										C	45387862	G	C	45387862	3	2	102	1	0	0	0	0	1	0	0	0	388	1175	41	1	220	1	AGPAT3	21	45387862	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	18257410	45387862	2742033	210	31803										
KRTAP10-3	386682	broad.mit.edu	37	chr21	45978005	45978005	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cgggagcacgtggggcggcaGaggagggacacgcaggaggc	22	9	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr21:45978005G>C	uc002zfj.1	-	1	639	c.594C>G	c.(592-594)CTC>CTG	p.L198L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	198	18 X 5 AA repeats of C-C-X(3).					keratin filament				skin(1)	1						TGGGGCGGCAGAGGAGGGACA	0.692													0	0	0	0.02938	0	7	32										C	45978005	G	C	45978005	2	2	102	1	0	0	0	0	0	0	0	1	8510	929	33	1		1	KRTAP10-3	21	45978005	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	590143	45978005	2151890	211	31804										
MED15	51586	broad.mit.edu	37	chr22	20909408	20909408	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggatggcccctcacagcatgGctgtcgtgtctacggcaact	12	13	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:20909408G>T	uc002zsp.2	+	5	504	c.424G>T	c.(424-426)GCT>TCT	p.A142S	MED15_uc002zsn.1_Missense_Mutation_p.A61S|MED15_uc002zso.2_Intron|MED15_uc002zsq.2_Missense_Mutation_p.A142S|MED15_uc010gso.2_Missense_Mutation_p.A142S|MED15_uc002zsr.2_Missense_Mutation_p.A116S|MED15_uc011ahs.1_Missense_Mutation_p.A116S|MED15_uc011aht.1_Missense_Mutation_p.A116S|MED15_uc002zss.2_Missense_Mutation_p.A61S	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	142					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TCACAGCATGGCTGTCGTGTC	0.567													1	0	2.56e-06	0.009096	2.65412e-06	3	6										T	20909408	G	T	20909408	3	4	102	1	0	0	0	0	1	0	0	0	9433	1203	42	4	442	4	MED15	22	20909408	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08		20909408	30395158	212	31805										
SLC7A4	6545	broad.mit.edu	37	chr22	21384120	21384120	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagtgtgggaggtgcagggtCgagttcccaaagacaagcac	15	9	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:21384120C>T	uc002zud.2	-	3	1571	c.1503G>A	c.(1501-1503)TCG>TCA	p.S501S	SLC7A4_uc002zue.2_Silent_p.S501S	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	501					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GGTGCAGGGTCGAGTTCCCAA	0.582													0	0	0	0.021553	0	6	25										T	21384120	C	T	21384120	2	4	102	1	0	0	0	0	0	0	0	1	14699	871	31	1		1	SLC7A4	22	21384120	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	474712	21384120	29920446	213	31806										
HPS4	89781	broad.mit.edu	37	chr22	26860275	26860275	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	aggatggtcttcgagctgctCttgggctccatgctgggtca	14	10	3	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:26860275C>G	uc003acl.2	-	11	1980	c.1321G>C	c.(1321-1323)GAG>CAG	p.E441Q	HPS4_uc003aci.2_Missense_Mutation_p.E436Q|HPS4_uc003acj.2_Missense_Mutation_p.E305Q|HPS4_uc003ack.2_Missense_Mutation_p.E232Q|HPS4_uc003acn.2_Missense_Mutation_p.E287Q|HPS4_uc010gvd.1_Missense_Mutation_p.E459Q|HPS4_uc003ach.2_Missense_Mutation_p.E176Q	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	441					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TCGAGCTGCTCTTGGGCTCCA	0.632									Hermansky-Pudlak_syndrome				0	0	0	0.144211	0	27	79										G	26860275	C	G	26860275	3	3	102	1	0	0	0	0	1	0	0	0	7341	922	32	1	821	1	HPS4	22	26860275	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	5476155	26860275	24444291	214	31807										
MORC2	22880	broad.mit.edu	37	chr22	31332626	31332626	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctgcttttgttcagaagcctCacacctgtagagacaaggta	9	10	2	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:31332626C>G	uc003aje.1	-	18	2787	c.1423G>C	c.(1423-1425)GAG>CAG	p.E475Q		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	537	CW-type.						ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						TCAGAAGCCTCACACCTGTAG	0.493													0	0	0	0.139131	0	40	44										G	31332626	C	G	31332626	3	3	102	1	0	0	0	0	1	0	0	0	9702	835	29	1	1529	1	MORC2	22	31332626	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	4472351	31332626	19971940	215	31808										
CELSR1	9620	broad.mit.edu	37	chr22	46787591	46787591	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	cagcggttgcactggcggccGatgacgccgggcttgcaggc	17	13	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chr22:46787591G>A	uc003bhw.1	-	15	6087	c.6087C>T	c.(6085-6087)ATC>ATT	p.I2029I	CELSR1_uc011arc.1_Silent_p.I350I	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2029	Extracellular (Potential).|Laminin EGF-like.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACTGGCGGCCGATGACGCCGG	0.682													0	0	0	0.021553	0	4	21										A	46787591	G	A	46787591	2	1	102	1	0	0	0	0	0	0	0	1	3221	1048	37	1		1	CELSR1	22	46787591	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	15454965	46787591	4516975	216	31809										
FAM47C	442444	broad.mit.edu	37	chrX	37027156	37027156	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gagtgtcccatctccgcccaCagcctcccaagactcaggtg	9	17	2	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647													0	0	0	0.021553	0	4	72										G	37027156	C	G	37027156	3	3	102	1	0	0	0	0	1	0	0	0	5571	479	17	4	675	4	FAM47C	23	37027156	Missense_Mutation	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08		37027156	118243404	217	31810										
MSN	4478	broad.mit.edu	37	chrX	64959692	64959692	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ctgggccgagacaaatacaaGaccctgcgccagatccggca	11	14	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:64959692G>A	uc004dwf.2	+	13	1869	c.1671G>A	c.(1669-1671)AAG>AAA	p.K557K		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	557					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						ACAAATACAAGACCCTGCGCC	0.547			T	ALK	ALCL								0	0	0	0.139131	0	43	58										A	64959692	G	A	64959692	2	1	102	1	0	0	0	0	0	0	0	1	9885	933	33	1		1	MSN	23	64959692	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	27932536	64959692	90310868	218	31811										
ACRC	93953	broad.mit.edu	37	chrX	70823836	70823836	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	atgattcggatgttcccgacGacagcagtgatgattcggaa	12	8	0	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:70823836G>A	uc004eae.2	+	8	1210	c.709G>A	c.(709-711)GAC>AAC	p.D237N	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	237	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					TGTTCCCGACGACAGCAGTGA	0.537													0	0	0	0.139131	0	248	47										A	70823836	G	A	70823836	3	1	102	1	0	0	0	0	1	0	0	0	171	1058	37	1	735	1	ACRC	23	70823836	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	5864144	70823836	84446724	219	31812										
PAK3	5063	broad.mit.edu	37	chrX	110439755	110439755	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccccatattggatggcacctGaggtggtgactcgaaaagct	12	10	0	2			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:110439755G>A	uc004epa.2	+	13	1366	c.1339G>A	c.(1339-1341)GAG>AAG	p.E447K	PAK3_uc010npt.1_Missense_Mutation_p.E432K|PAK3_uc010npu.1_Missense_Mutation_p.E432K|PAK3_uc004eoy.1_Missense_Mutation_p.E187K|PAK3_uc004eoz.2_Missense_Mutation_p.E432K|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.E468K|PAK3_uc010npw.1_Missense_Mutation_p.E453K	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	447	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						GATGGCACCTGAGGTGGTGAC	0.468										TSP Lung(19;0.15)			0	0	0	0.139131	0	49	57										A	110439755	G	A	110439755	3	1	102	1	0	0	0	0	1	0	0	0	11402	1291	45	1	1456	1	PAK3	23	110439755	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	39615919	110439755	44830805	220	31813										
KLHL13	90293	broad.mit.edu	37	chrX	117053581	117053581	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaaggttgtccatattaagaGaaagctttgcagtataaatg	10	4	0	1			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:117053581G>C	uc004eql.2	-	4	535	c.473C>G	c.(472-474)TCT>TGT	p.S158C	KLHL13_uc004eqk.2_Missense_Mutation_p.S107C|KLHL13_uc011mtn.1_5'UTR|KLHL13_uc011mto.1_Missense_Mutation_p.S152C|KLHL13_uc011mtp.1_Missense_Mutation_p.S160C|KLHL13_uc004eqm.2_Missense_Mutation_p.S107C|KLHL13_uc011mtq.1_Missense_Mutation_p.S142C	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	158	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						CATATTAAGAGAAAGCTTTGC	0.383													0	0	0	0.099896	0	23	43										C	117053581	G	C	117053581	3	2	102	1	0	0	0	0	1	0	0	0	8369	942	33	1	1510	1	KLHL13	23	117053581	Missense_Mutation	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	6613826	117053581	38216979	221	31814										
CDR1	1038	broad.mit.edu	37	chrX	139866322	139866322	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	tccctcaaatccatagcttcCgaaaaatccaggtcttccag	5	14	2	0			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:139866322C>T	uc004fbg.1	-	1	402	c.210G>A	c.(208-210)TCG>TCA	p.S70S	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	70	23 X 6 AA approximate repeats.|12.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCATAGCTTCCGAAAAATCCA	0.458													0	0	0	0.115264	0	3	48										T	139866322	C	T	139866322	2	4	102	1	0	0	0	0	0	0	0	1	3171	639	23	2		2	CDR1	23	139866322	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	22812741	139866322	15404238	222	31815										
SPANXN2	494119	broad.mit.edu	37	chrX	142795255	142795255	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gaagatccttcagatgagtcCaggtcttcgtcctcctgtga	10	11	2	4			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:142795255C>T	uc004fbz.2	-	2	1177	c.423G>A	c.(421-423)CTG>CTA	p.L141L		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	141										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CAGATGAGTCCAGGTCTTCGT	0.517													0	0	0	0.105934	0	6	227										T	142795255	C	T	142795255	2	4	102	1	0	0	0	0	0	0	0	1	14991	581	21	2		2	SPANXN2	23	142795255	Silent	SNP	C	TCGA-GC-A3I6-01A-11D-A20D-08	2928933	142795255	12475305	223	31816										
MAGEA6	4105	broad.mit.edu	37	chrX	151870055	151870055	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ccaagaagctgctcacccaaTatttcgtgcaggaaaactac	7	12	1	1	rs140963484	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151870055T>C	uc004ffq.1	+	3	939	c.745T>C	c.(745-747)TAT>CAT	p.Y249H	MAGEA6_uc004ffr.1_Missense_Mutation_p.Y249H|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	249	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCACCCAATATTTCGTGCA	0.547													0	0	0	0.083992	0	21	89										C	151870055	T	C	151870055	3	2	102	1	0	0	0	0	1	0	0	0	9170	1406	49	5	747	5	MAGEA6	23	151870055	Missense_Mutation	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	9074800	151870055	3400505	224	31817										
MAGEA3	4102	broad.mit.edu	37	chrX	151935357	151935357	+	Silent	SNP	T	T	C													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcccttggaccccacaggaaTtcataacatgcaggatcact					rs35014597	byFrequency	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151935357T>C	uc004fgp.2	-	3	1019	c.810A>G	c.(808-810)GAA>GAG	p.E270E		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	270	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CCCACAGGAATTCATAACATG	0.532													0	0	0	0.038147	0	4	145										C	151935357	T	C	151935357	2	2	102	1	0	0	0	0	0	0	0	1	9167	1490	52	5		5	MAGEA3	23	151935357	Silent	SNP	T	TCGA-GC-A3I6-01A-11D-A20D-08	65302	151935357	3335203	225	31818	158	2								
MAGEA3	4102	broad.mit.edu	37	chrX	151935363	151935363	+	Silent	SNP	A	A	G													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	ggaccccacaggaattcataAcatgcaggatcactgccggg					rs35137903	by1000genomes	TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:151935363A>G	uc004fgp.2	-	3	1013	c.804T>C	c.(802-804)TGT>TGC	p.C268C		NM_005362	NP_005353	P43357	MAGA3_HUMAN	melanoma antigen family A, 3	268	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGAATTCATAACATGCAGGAT	0.517													0	0	0	0.080935	0	7	138										G	151935363	A	G	151935363	2	3	102	1	0	0	0	0	0	0	0	1	9167	41	2	5		5	MAGEA3	23	151935363	Silent	SNP	A	TCGA-GC-A3I6-01A-11D-A20D-08	6	151935363	3335197	226	31819	158	2								
ZNF185	7739	broad.mit.edu	37	chrX	152087570	152087572	+	In_Frame_Del	DEL	GAG	GAG	-													0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gctctacatcaggggacaccGaggaggaggaggaggaggag							TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:152087570_152087572delGAG	uc010ntv.1	+	7	512_514	c.475_477delGAG	c.(475-477)GAGdel	p.E165del	ZNF185_uc011myg.1_In_Frame_Del_p.E165del|ZNF185_uc011myh.1_In_Frame_Del_p.E165del|ZNF185_uc011myi.1_In_Frame_Del_p.E165del|ZNF185_uc011myj.1_In_Frame_Del_p.E165del|ZNF185_uc011myk.1_In_Frame_Del_p.E165del|ZNF185_uc004fgw.3_In_Frame_Del_p.E30del|ZNF185_uc004fgu.2_5'UTR|ZNF185_uc004fgv.2_5'Flank	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	165	Poly-Glu.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGACACCgaggaggaggagg	0.522																		7	38	---	---								-	152087572	GAG	-	152087570	7	5	102	1	0	1	0	1	0	0	0	0	17749	1059	37	0	516	0	ZNF185	23	152087570	In_Frame_Del	DEL	GAG	TCGA-GC-A3I6-01A-11D-A20D-08	152207	152087570	3182990	227	31820										
HCFC1	3054	broad.mit.edu	37	chrX	153224926	153224926	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.469026548672566	106	1.59468031641197e-36	3.74361798130898	4.87011330749988	3.23317478662873	0.0124185357158496	0.0393758449526939	78	gcctgaggaccggtcactttGagaacagcagggacacctga	13	11	1	3			TCGA-GC-A3I6-01A-11D-A20D-08	TCGA-GC-A3I6-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	372feefe-ee84-4833-8651-8f023f38a56a	f2da1011-c718-4bef-9180-5b846cf31308	g.chrX:153224926G>A	uc004fjp.2	-	9	1989	c.1461C>T	c.(1459-1461)CTC>CTT	p.L487L		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	487					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGTCACTTTGAGAACAGCAG	0.612													0	0	0	0.049695	0	16	26										A	153224926	G	A	153224926	2	1	102	1	0	0	0	0	0	0	0	1	6991	1277	45	1		1	HCFC1	23	153224926	Silent	SNP	G	TCGA-GC-A3I6-01A-11D-A20D-08	1137356	153224926	2045634	228	31821										
ARHGEF19	128272	broad.mit.edu	37	chr1	16531255	16531255	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cctgactgccccgactcactCcttccgccgagagagcagca	9	18	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:16531255C>T	uc001ayc.1	-	12	2043	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	ARHGEF19_uc009voo.1_5'UTR|ARHGEF19_uc001ayb.1_Missense_Mutation_p.E113K	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	636	PH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CCGACTCACTCCTTCCGCCGA	0.617													0	0	0	0.010729	0	10	20										T	16531255	C	T	16531255	3	4	103	1	0	0	0	0	1	0	0	0	902	869	30	1	522	1	ARHGEF19	1	16531255	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		16531255	232719366	1	31822										
LUZP1	7798	broad.mit.edu	37	chr1	23418665	23418665	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gggaggttctaggtgcccctCgggttttagccttttctcta	12	10	2	0	rs141739515	by1000genomes	TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:23418665C>T	uc001bgk.2	-	4	2474	c.2090G>A	c.(2089-2091)CGA>CAA	p.R697Q	LUZP1_uc010odv.1_Missense_Mutation_p.R697Q|LUZP1_uc001bgl.2_Missense_Mutation_p.R697Q|LUZP1_uc001bgm.1_Missense_Mutation_p.R697Q	NM_033631	NP_361013	Q86V48	LUZP1_HUMAN	leucine zipper protein 1	697						nucleus					0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		AGGTGCCCCTCGGGTTTTAGC	0.463													0	0	0	0.008871	0	19	382										T	23418665	C	T	23418665	3	4	103	1	0	0	0	0	1	0	0	0	9086	884	31	1	1148	1	LUZP1	1	23418665	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	6887410	23418665	225831956	2	31823										
YTHDF2	51441	broad.mit.edu	37	chr1	29070328	29070328	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aactgcgacacattcgcctaGagaacaacgagaataaacca	7	11	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:29070328G>A	uc001brc.2	+	4	2043	c.1546G>A	c.(1546-1548)GAG>AAG	p.E516K	YTHDF2_uc001brd.2_Missense_Mutation_p.E513K|YTHDF2_uc010ofx.1_Missense_Mutation_p.E466K|YTHDF2_uc001bre.2_Missense_Mutation_p.E466K	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	516	YTH.				humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CATTCGCCTAGAGAACAACGA	0.478													0	0	0	0.02938	0	6	94										A	29070328	G	A	29070328	3	1	103	1	0	0	0	0	1	0	0	0	17496	943	33	1	1560	1	YTHDF2	1	29070328	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	5651663	29070328	220180293	3	31824										
CMPK1	51727	broad.mit.edu	37	chr1	47840885	47840885	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gcagaattcagacctaccttCagtcaacaaagccaattatt	5	11	3	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:47840885C>T	uc001cri.2	+	5	714	c.565C>T	c.(565-567)CAG>TAG	p.Q189*	CMPK1_uc010omp.1_Nonsense_Mutation_p.Q140*|CMPK1_uc010omq.1_RNA	NM_016308	NP_057392	P30085	KCY_HUMAN	UMP-CMP kinase 1 isoform a	157					nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleus	ATP binding|cytidylate kinase activity|nucleoside phosphate kinase activity|uridine kinase activity			ovary(1)	1					Gemcitabine(DB00441)	GACCTACCTTCAGTCAACAAA	0.368													0	0	0	0.008291	0	10	164										T	47840885	C	T	47840885	4	4	103	1	0	0	0	0	0	1	0	0	3580	827	29	1	583	1	CMPK1	1	47840885	Nonsense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	18770557	47840885	201409736	4	31825										
LRRC7	57554	broad.mit.edu	37	chr1	70505042	70505042	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctcatgagctgcccccaactGataggtacggcagaccccca	9	16	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:70505042G>A	uc001dep.2	+	19	3451	c.3421G>A	c.(3421-3423)GAT>AAT	p.D1141N	LRRC7_uc009wbg.2_Missense_Mutation_p.D425N|LRRC7_uc001deq.2_Missense_Mutation_p.D382N	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1141						centrosome|focal adhesion|nucleolus	protein binding	p.D1141N(1)		ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GCCCCCAACTGATAGGTACGG	0.572													0	0	0	0.025465	0	40	112										A	70505042	G	A	70505042	3	1	103	1	0	0	0	0	1	0	0	0	9020	1290	45	1	3495	1	LRRC7	1	70505042	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	22664157	70505042	178745579	5	31826										
COL11A1	1301	broad.mit.edu	37	chr1	103404632	103404632	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gctgcctttttgtcccggctCaccaatttcaccctgaaatt	6	14	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:103404632C>T	uc001dul.2	-	44	3715	c.3397G>A	c.(3397-3399)GAG>AAG	p.E1133K	COL11A1_uc001duk.2_Missense_Mutation_p.E329K|COL11A1_uc001dum.2_Missense_Mutation_p.E1145K|COL11A1_uc001dun.2_Missense_Mutation_p.E1094K|COL11A1_uc009weh.2_Missense_Mutation_p.E1017K	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1133	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGTCCCGGCTCACCAATTTCA	0.333													0	0	0	0.017118	0	32	81										T	103404632	C	T	103404632	3	4	103	1	0	0	0	0	1	0	0	0	3667	835	29	1	2119	1	COL11A1	1	103404632	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	32899590	103404632	145845989	6	31827										
DENND2C	163259	broad.mit.edu	37	chr1	115166229	115166229	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tcgtctgtgagttccgatttCgaaagtgctgaatatcctca	9	9	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:115166229C>T	uc001efd.1	-	5	1544	c.842G>A	c.(841-843)CGA>CAA	p.R281Q	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.R281Q	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	281										skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTTCCGATTTCGAAAGTGCTG	0.303													0	0	0	0.009096	0	4	42										T	115166229	C	T	115166229	3	4	103	1	0	0	0	0	1	0	0	0	4430	884	31	1	1837	1	DENND2C	1	115166229	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	11761597	115166229	134084392	7	31828										
BOLA1	51027	broad.mit.edu	37	chr1	149871751	149871751	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tggaggaggccctgagccccGaggtgctagagcttcgcaac	15	12	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:149871751G>A	uc001etf.2	+	2	260	c.139G>A	c.(139-141)GAG>AAG	p.E47K		NM_016074	NP_057158	Q9Y3E2	BOLA1_HUMAN	bolA-like 1	47						extracellular region	protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCTGAGCCCCGAGGTGCTAGA	0.677													0	0	0	0.009096	0	4	36										A	149871751	G	A	149871751	3	1	103	1	0	0	0	0	1	0	0	0	1485	1059	37	1	141	1	BOLA1	1	149871751	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	34705522	149871751	99378870	8	31829										
SEMA4A	64218	broad.mit.edu	37	chr1	156145022	156145022	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ccgaacctgttgcctcctgtCtgcccccaacctgtgagtgc	9	17	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:156145022C>G	uc001fnl.2	+	13	1684	c.1580C>G	c.(1579-1581)TCT>TGT	p.S527C	SEMA4A_uc009wrq.2_Missense_Mutation_p.S527C|SEMA4A_uc001fnm.2_Missense_Mutation_p.S527C|SEMA4A_uc001fnn.2_Missense_Mutation_p.S395C|SEMA4A_uc001fno.2_Missense_Mutation_p.S527C	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	527	Extracellular (Potential).|PSI.				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TGCCTCCTGTCTGCCCCCAAC	0.617													0	0	0	0.01441	0	68	192										G	156145022	C	G	156145022	3	3	103	1	0	0	0	0	1	0	0	0	14031	913	32	1	1626	1	SEMA4A	1	156145022	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	6273271	156145022	93105599	9	31830										
OR10K1	391109	broad.mit.edu	37	chr1	158435847	158435847	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ccacctccctagtatttcatCtgcccttccactcctccaac	2	20	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:158435847C>G	uc010pij.1	+	1	496	c.496C>G	c.(496-498)CTG>GTG	p.L166V		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGTATTTCATCTGCCCTTCCA	0.547													0	0	0	0.01441	0	64	180										G	158435847	C	G	158435847	3	3	103	1	0	0	0	0	1	0	0	0	10913	912	32	1	498	1	OR10K1	1	158435847	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	2290825	158435847	90814774	10	31831										
USP21	27005	broad.mit.edu	37	chr1	161132715	161132715	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttgtctggctgtagccagcaGgatgcccaagagttcctgaa	12	10	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:161132715G>A	uc010pke.1	+	7	1277	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q	USP21_uc010pkc.1_Silent_p.Q300Q|USP21_uc010pkd.1_Silent_p.Q300Q|USP21_uc010pkf.1_Silent_p.Q300Q	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	300					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTAGCCAGCAGGATGCCCAAG	0.557													0	0	0	0.004482	0	9	78										A	161132715	G	A	161132715	2	1	103	1	0	0	0	0	0	0	0	1	17050	991	35	2		2	USP21	1	161132715	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	2696868	161132715	88117906	11	31832										
TPR	7175	broad.mit.edu	37	chr1	186283842	186283842	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tcgtctgaaaggctttggttGactactactagtatctaaga	9	7	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:186283842G>A	uc001grv.2	-	50	7252	c.6955C>T	c.(6955-6957)CAA>TAA	p.Q2319*		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	2319					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		GGCTTTGGTTGACTACTACTA	0.333			T	NTRK1	papillary thyroid								0	0	0	0.02938	0	6	58										A	186283842	G	A	186283842	4	1	103	1	0	0	0	0	0	1	0	0	16413	1299	45	1	144	1	TPR	1	186283842	Nonsense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	25151127	186283842	62966779	12	31833										
RBBP5	5929	broad.mit.edu	37	chr1	205069074	205069074	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gagttctcctctcgtcccatGgagaatcttcaccaggttgc	9	13	4	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr1:205069074G>A	uc001hbu.1	-	8	1001	c.871C>T	c.(871-873)CAT>TAT	p.H291Y	RBBP5_uc010prd.1_Missense_Mutation_p.H326Y|RBBP5_uc001hbv.1_Missense_Mutation_p.H291Y|RBBP5_uc010pre.1_Missense_Mutation_p.H158Y	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	291	WD 5.				histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CTCGTCCCATGGAGAATCTTC	0.458													0	0	0	0.01441	0	47	196										A	205069074	G	A	205069074	3	1	103	1	0	0	0	0	1	0	0	0	13102	1348	47	2	773	2	RBBP5	1	205069074	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	18785232	205069074	44181547	13	31834										
C2orf77	129881	broad.mit.edu	37	chr2	170502423	170502423	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ccctgagagttataaaaaggGagctggactccagtaacatc	10	9	0	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr2:170502423G>C	uc002ufe.2	-	9	1681	c.1587C>G	c.(1585-1587)CTC>CTG	p.L529L		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	529											0						TATAAAAAGGGAGCTGGACTC	0.408													0	0	0	0.016522	0	25	71										C	170502423	G	C	170502423	2	2	103	1	0	0	0	0	0	0	0	1	2194	1161	41	1		1	C2orf77	2	170502423	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		170502423	72696950	14	31835										
SPHKAP	80309	broad.mit.edu	37	chr2	228882660	228882660	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cggcagggtacgttgggtgtCatcagaaactcactccctct	11	12	4	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr2:228882660C>T	uc002vpq.2	-	7	2957	c.2910G>A	c.(2908-2910)ATG>ATA	p.M970I	SPHKAP_uc002vpp.2_Missense_Mutation_p.M970I|SPHKAP_uc010zlx.1_Missense_Mutation_p.M970I	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	970						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGTTGGGTGTCATCAGAAACT	0.527													0	0	0	0.016723	0	13	98										T	228882660	C	T	228882660	3	4	103	1	0	0	0	0	1	0	0	0	15047	826	29	1	2216	1	SPHKAP	2	228882660	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	58380237	228882660	14316713	15	31836										
HTR2B	3357	broad.mit.edu	37	chr2	231978477	231978477	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cacaccactgtaatcttgatGaatgctgtagcccgtgagtt	9	10	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr2:231978477G>A	uc002vro.2	-	3	1024	c.519C>T	c.(517-519)TTC>TTT	p.F173F	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Intron	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	173	Helical; Name=4; (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	TAATCTTGATGAATGCTGTAG	0.428													0	0	0	0.016723	0	12	229										A	231978477	G	A	231978477	2	1	103	1	0	0	0	0	0	0	0	1	7442	1281	45	1		1	HTR2B	2	231978477	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	3095817	231978477	11220896	16	31837										
EIF4E2	9470	broad.mit.edu	37	chr2	233421234	233421234	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aagaatcagagcagtagcaaGagaaaggtgagtgttggctg	15	4	1	4			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr2:233421234G>C	uc002vta.2	+	2	207	c.129G>C	c.(127-129)AAG>AAC	p.K43N	EIF4E2_uc002vtb.1_Missense_Mutation_p.K43N|EIF4E2_uc002vsz.2_Missense_Mutation_p.K43N|EIF4E2_uc010zmi.1_Missense_Mutation_p.K43N	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	43					regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GCAGTAGCAAGAGAAAGGTGA	0.408													0	0	0	0.009096	0	4	23										C	233421234	G	C	233421234	3	2	103	1	0	0	0	0	1	0	0	0	5030	933	33	1	135	1	EIF4E2	2	233421234	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	1442757	233421234	9778139	17	31838										
GBX2	2637	broad.mit.edu	37	chr2	237074842	237074842	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tccagcagctgctcgctggtGaaggcagtccgccgccgccg	14	16	0	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr2:237074842G>T	uc002vvw.1	-	2	800	c.762C>A	c.(760-762)TTC>TTA	p.F254L	GBX2_uc010zng.1_3'UTR	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	254	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		GCTCGCTGGTGAAGGCAGTCC	0.672													1	0	0.000274275	0.004482	0.000280767	8	61										T	237074842	G	T	237074842	3	4	103	1	0	0	0	0	1	0	0	0	6281	1281	45	3	288	3	GBX2	2	237074842	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	3653608	237074842	6124531	18	31839										
C3orf20	84077	broad.mit.edu	37	chr3	14756871	14756871	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ggctatgtagtccacaagtgGagctggacttccaggacaga	13	9	0	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:14756871G>A	uc003byy.2	+	9	1793	c.1389G>A	c.(1387-1389)TGG>TGA	p.W463*	C3orf20_uc003byz.2_Nonsense_Mutation_p.W341*|C3orf20_uc003bza.2_Nonsense_Mutation_p.W341*|C3orf20_uc003bzb.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	463						cytoplasm|integral to membrane		p.W463*(1)		ovary(3)|skin(1)	4						TCCACAAGTGGAGCTGGACTT	0.537													0	0	0	0.02938	0	7	68										A	14756871	G	A	14756871	4	1	103	1	0	0	0	0	0	1	0	0	2213	1183	41	1	1415	1	C3orf20	3	14756871	Nonsense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		14756871	183265559	19	31840										
TMPPE	643853	broad.mit.edu	37	chr3	33134911	33134911	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgaagctggcccagaggagcGacagccgtccgcaggaccga	15	13	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:33134911G>A	uc003cfk.2	-	2	968	c.777C>T	c.(775-777)GTC>GTT	p.V259V	GLB1_uc003cfh.1_Intron|GLB1_uc003cfi.1_Intron|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Intron|TMPPE_uc011axl.1_Silent_p.V122V	NM_001039770	NP_001034859	Q6ZT21	TMPPE_HUMAN	transmembrane protein with	259						integral to membrane	metal ion binding				0						CCAGAGGAGCGACAGCCGTCC	0.537													0	0	0	0.030593	0	24	86										A	33134911	G	A	33134911	2	1	103	1	0	0	0	0	0	0	0	1	16235	1045	37	1		1	TMPPE	3	33134911	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	18378040	33134911	164887519	20	31841										
SCN5A	6331	broad.mit.edu	37	chr3	38591869	38591869	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gggaagtcggcgagatcttcActgtggctgtagtcagaccc	14	10	3	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:38591869A>G	uc003cio.2	-	28	6188	c.5994T>C	c.(5992-5994)AGT>AGC	p.S1998S	SCN5A_uc003cin.2_Silent_p.S1997S|SCN5A_uc003cil.3_Silent_p.S1998S|SCN5A_uc010hhi.2_Silent_p.S1980S|SCN5A_uc010hhk.2_Silent_p.S1965S|SCN5A_uc011ayr.1_Silent_p.S1944S	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1998					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CGAGATCTTCACTGTGGCTGT	0.597													0	0	0	0.0333	0	15	91										G	38591869	A	G	38591869	2	3	103	1	0	0	0	0	0	0	0	1	13922	156	6	5		5	SCN5A	3	38591869	Silent	SNP	A	TCGA-GC-A3OO-01A-11D-A22Z-08	5456958	38591869	159430561	21	31842										
PHLDB2	90102	broad.mit.edu	37	chr3	111604194	111604194	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gctccatttcaggacgtgatGacctgatggattatcaccgg	11	10	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:111604194G>A	uc010hqa.2	+	2	1681	c.1270G>A	c.(1270-1272)GAC>AAC	p.D424N	PHLDB2_uc003dyc.2_Missense_Mutation_p.D451N|PHLDB2_uc003dyd.2_Missense_Mutation_p.D424N|PHLDB2_uc003dyg.2_Missense_Mutation_p.D424N|PHLDB2_uc003dyh.2_Missense_Mutation_p.D424N|PHLDB2_uc003dye.3_Missense_Mutation_p.D424N|PHLDB2_uc003dyf.3_Missense_Mutation_p.D424N	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	424						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AGGACGTGATGACCTGATGGA	0.522													0	0	0	0.008291	0	10	113										A	111604194	G	A	111604194	3	1	103	1	0	0	0	0	1	0	0	0	11852	1290	45	1	1357	1	PHLDB2	3	111604194	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	73012325	111604194	86418236	22	31843										
PARP9	83666	broad.mit.edu	37	chr3	122259634	122259634	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttccacgttgaatcccatcaGattgatggcaggagatctag	10	9	2	4			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:122259634G>A	uc010hri.2	-	8	1700	c.1555C>T	c.(1555-1557)CTG>TTG	p.L519L	PARP9_uc003eff.3_Silent_p.L484L|PARP9_uc011bjs.1_Silent_p.L484L|PARP9_uc003efg.2_Silent_p.L64L|PARP9_uc003efi.2_Silent_p.L484L|PARP9_uc003efh.2_Silent_p.L519L|PARP9_uc003efj.2_Silent_p.L484L	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	519					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		AATCCCATCAGATTGATGGCA	0.438													0	0	0	0.004482	0	9	161										A	122259634	G	A	122259634	2	1	103	1	0	0	0	0	0	0	0	1	11466	933	33	1		1	PARP9	3	122259634	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	10655440	122259634	75762796	23	31844										
COL6A6	131873	broad.mit.edu	37	chr3	130293317	130293317	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cacaacttcgatgaactgaaGaaggtcaataaaaggatcgt	9	7	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:130293317G>A	uc010htl.2	+	7	3526	c.3495G>A	c.(3493-3495)AAG>AAA	p.K1165K		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1165	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ATGAACTGAAGAAGGTCAATA	0.463													0	0	0	0.028581	0	17	61										A	130293317	G	A	130293317	2	1	103	1	0	0	0	0	0	0	0	1	3703	933	33	1		1	COL6A6	3	130293317	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	8033683	130293317	67729113	24	31845										
SRPRB	58477	broad.mit.edu	37	chr3	133524732	133524732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gccgggtggcagatggcggcGgtgccgggggcaccttccag	20	12	0	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:133524732G>A	uc003epx.1	+	1	56	c.40G>A	c.(40-42)GGT>AGT	p.G14S		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	14						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						AGATGGCGGCGGTGCCGGGGG	0.672													0	0	0	0.010504	0	21	61										A	133524732	G	A	133524732	3	1	103	1	0	0	0	0	1	0	0	0	15162	1116	39	2	42	2	SRPRB	3	133524732	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	3231415	133524732	64497698	25	31846										
PLD1	5337	broad.mit.edu	37	chr3	171404524	171404524	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gactcactggacgggtgaaaGagtttgaagtggggttttaa	15	4	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:171404524G>A	uc003fhs.2	-	16	1934	c.1818C>T	c.(1816-1818)CTC>CTT	p.L606L	PLD1_uc003fht.2_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	606	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACGGGTGAAAGAGTTTGAAGT	0.368													0	0	0	0.007413	0	17	185										A	171404524	G	A	171404524	2	1	103	1	0	0	0	0	0	0	0	1	12045	929	33	1		1	PLD1	3	171404524	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	37879792	171404524	26617906	26	31847										
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.02938	0	6	87										A	178936082	G	A	178936082	3	1	103	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1658	1	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	7531558	178936082	19086348	27	31848										
FXR1	8087	broad.mit.edu	37	chr3	180675620	180675620	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	actaaaggaaaagtaattggAaaaaatggcaaagttattca	8	3	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr3:180675620A>G	uc003fkq.2	+	10	916	c.894A>G	c.(892-894)GGA>GGG	p.G298G	FXR1_uc003fkp.2_Silent_p.G213G|FXR1_uc003fkr.2_Silent_p.G298G|FXR1_uc011bqj.1_Silent_p.G212G|FXR1_uc003fks.2_Silent_p.G212G|FXR1_uc011bqk.1_Silent_p.G249G|FXR1_uc011bql.1_Silent_p.G285G	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	298	KH 2.				apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			AAGTAATTGGAAAAAATGGCA	0.343													0	0	0	0.008291	0	10	76										G	180675620	A	G	180675620	2	3	103	1	0	0	0	0	0	0	0	1	6115	233	9	5		5	FXR1	3	180675620	Silent	SNP	A	TCGA-GC-A3OO-01A-11D-A22Z-08	1739538	180675620	17346810	28	31849										
PTPN13	5783	broad.mit.edu	37	chr4	87671842	87671842	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aaaagagaagaatgacaaagCttcatgggaggaaaagccta	11	5	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr4:87671842C>G	uc003hpz.2	+	18	3350	c.2870C>G	c.(2869-2871)GCT>GGT	p.A957G	PTPN13_uc003hpy.2_Missense_Mutation_p.A957G|PTPN13_uc003hqa.2_Missense_Mutation_p.A957G|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	957						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		AATGACAAAGCTTCATGGGAG	0.423													0	0	0	0.008291	0	11	32										G	87671842	C	G	87671842	3	3	103	1	0	0	0	0	1	0	0	0	12782	797	28	4	2936	4	PTPN13	4	87671842	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		87671842	103482434	29	31850										
SLC25A31	83447	broad.mit.edu	37	chr4	128651894	128651894	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ccccgaggcgcggtacaaagGcatggtggactgcctggtgc	16	12	0	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr4:128651894G>T	uc003ifl.2	+	1	340	c.194G>T	c.(193-195)GGC>GTC	p.G65V		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	65	Solcar 1.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						CGGTACAAAGGCATGGTGGAC	0.677													1	0	0.000602214	0.014758	0.000609258	5	33										T	128651894	G	T	128651894	3	4	103	1	0	0	0	0	1	0	0	0	14495	1203	42	4	196	4	SLC25A31	4	128651894	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	40980052	128651894	62502382	30	31851										
ADAM29	11086	broad.mit.edu	37	chr4	175899002	175899002	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aacctcgggtgatgccttctCagagtcaacctcctgtgatg	10	12	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr4:175899002C>T	uc003iuc.2	+	5	2996	c.2326C>T	c.(2326-2328)CAG>TAG	p.Q776*	ADAM29_uc003iud.2_Nonsense_Mutation_p.Q776*|ADAM29_uc010irr.2_Nonsense_Mutation_p.Q776*|ADAM29_uc011cki.1_Nonsense_Mutation_p.Q776*	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	776	Cytoplasmic (Potential).|9 X 9 AA approximate repeats.|5.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GATGCCTTCTCAGAGTCAACC	0.567													0	0	0	0.020292	0	14	115										T	175899002	C	T	175899002	4	4	103	1	0	0	0	0	0	1	0	0	247	827	29	1	2328	1	ADAM29	4	175899002	Nonsense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	47247108	175899002	15255274	31	31852										
PRDM9	56979	broad.mit.edu	37	chr5	23526534	23526534	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gcaatatccagatccacacaGccgtaatgacaaaaccaaag	6	12	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr5:23526534G>A	uc003jgo.2	+	11	1519	c.1337G>A	c.(1336-1338)AGC>AAC	p.S446N		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	446					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GATCCACACAGCCGTAATGAC	0.473										HNSCC(3;0.000094)			0	0	0	0.01441	0	69	67										A	23526534	G	A	23526534	3	1	103	1	0	0	0	0	1	0	0	0	12463	971	34	2	1375	2	PRDM9	5	23526534	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		23526534	157388726	32	31853										
PDZD2	23037	broad.mit.edu	37	chr5	32091004	32091004	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgtcccgctccaagctccagGagctgagagccttgagcatg	12	13	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr5:32091004G>A	uc003jhl.2	+	20	7838	c.7450G>A	c.(7450-7452)GAG>AAG	p.E2484K	PDZD2_uc003jhm.2_Missense_Mutation_p.E2484K	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	2484					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CAAGCTCCAGGAGCTGAGAGC	0.592													0	0	0	0.010729	0	12	171										A	32091004	G	A	32091004	3	1	103	1	0	0	0	0	1	0	0	0	11701	1175	41	1	7524	1	PDZD2	5	32091004	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	8564470	32091004	148824256	33	31854										
SPINK5	11005	broad.mit.edu	37	chr5	147481356	147481356	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tttcacaggagttgtgtagtGaataccgcaaatccaggaaa	10	7	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr5:147481356G>A	uc003lox.2	+	15	1388	c.1315G>A	c.(1315-1317)GAA>AAA	p.E439K	SPINK5_uc010jgs.1_Missense_Mutation_p.E411K|SPINK5_uc010jgr.2_Missense_Mutation_p.E420K|SPINK5_uc003low.2_Missense_Mutation_p.E439K|SPINK5_uc003loy.2_Missense_Mutation_p.E439K	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	439	Kazal-like 7.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGTGTAGTGAATACCGCAA	0.428													0	0	0	0.004482	0	8	76										A	147481356	G	A	147481356	3	1	103	1	0	0	0	0	1	0	0	0	15061	1291	45	1	1373	1	SPINK5	5	147481356	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	115390352	147481356	33433904	34	31855										
TBC1D9B	23061	broad.mit.edu	37	chr5	179290667	179290667	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtggggctgcaggcctccccGcccaccagcaccgtgtcgtc	13	18	0	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr5:179290667G>A	uc003mlh.2	-	22	3571	c.3534C>T	c.(3532-3534)GGC>GGT	p.G1178G	TBC1D9B_uc003mli.2_Silent_p.G1161G|TBC1D9B_uc003mlj.2_Silent_p.G1160G|TBC1D9B_uc003mlf.2_Silent_p.G252G|TBC1D9B_uc003mlg.2_Silent_p.G337G|TBC1D9B_uc011dgv.1_Silent_p.G337G	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1178						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGCCTCCCCGCCCACCAGCA	0.627													0	0	0	0.010729	0	12	54										A	179290667	G	A	179290667	2	1	103	1	0	0	0	0	0	0	0	1	15625	1074	38	2		2	TBC1D9B	5	179290667	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	31809311	179290667	1624593	35	31856										
PHACTR1	221692	broad.mit.edu	37	chr6	13273104	13273104	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttccgtaggcggctgagccaGaggccaactgcagaggaact	14	11	0	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:13273104G>C	uc010jpc.2	+	11	1736	c.1404G>C	c.(1402-1404)CAG>CAC	p.Q468H	PHACTR1_uc003nag.1_Missense_Mutation_p.Q468H|PHACTR1_uc003nah.1_Missense_Mutation_p.Q468H|TBC1D7_uc003naj.2_Intron	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	468	RPEL 3.					cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GGCTGAGCCAGAGGCCAACTG	0.458													0	0	0	0.010504	0	21	289										C	13273104	G	C	13273104	3	2	103	1	0	0	0	0	1	0	0	0	11809	933	33	1	1438	1	PHACTR1	6	13273104	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		13273104	157841963	36	31857										
HIST1H4D	8360	broad.mit.edu	37	chr6	26188994	26188994	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtgtactgtagaggtaagctCagccgccgaagccataaaga	12	9	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:26188994C>T	uc003ngu.2	-	1	311	c.311G>A	c.(310-312)TGA>TAA	p.*104*		NM_003539	NP_003530	P62805	H4_HUMAN	histone cluster 1, H4d	104					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				GAGGTAAGCTCAGCCGCCGAA	0.537													0	0	0	0.004482	0	8	61										T	26188994	C	T	26188994	2	4	103	1	0	0	0	0	0	0	0	1	7168	837	29	1		1	HIST1H4D	6	26188994	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	12915890	26188994	144926073	37	31858										
NOTCH4	4855	broad.mit.edu	37	chr6	32163377	32163377	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ccagggccacccaatcacagGgccagtcatccgttgagacc	10	16	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:32163377G>A	uc003obb.2	-	30	5988	c.5849C>T	c.(5848-5850)CCC>CTC	p.P1950L	GPSM3_uc003oax.3_5'Flank|GPSM3_uc003oay.3_5'Flank|GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_3'UTR|NOTCH4_uc003oba.2_Missense_Mutation_p.P610L|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1950	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CCAATCACAGGGCCAGTCATC	0.647													0	0	0	0.013537	0	13	111										A	32163377	G	A	32163377	3	1	103	1	0	0	0	0	1	0	0	0	10551	1232	43	2	166	2	NOTCH4	6	32163377	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	5974383	32163377	138951690	38	31859										
PSMB8	5696	broad.mit.edu	37	chr6	32810816	32810816	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtgccatgggccatctcaatCtgaacgttcctttctccgtc	8	14	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:32810816C>T	uc003oce.2	-	2	241	c.198G>A	c.(196-198)CAG>CAA	p.Q66Q	PSMB8_uc003ocf.2_Silent_p.Q62Q|PSMB8_uc011dqh.1_Silent_p.Q66Q	NM_148919	NP_683720	P28062	PSB8_HUMAN	proteasome beta 8 subunit isoform E2 proprotein	66					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1						CCATCTCAATCTGAACGTTCC	0.507													0	0	0	0.004482	0	7	69										T	32810816	C	T	32810816	2	4	103	1	0	0	0	0	0	0	0	1	12683	912	32	1		1	PSMB8	6	32810816	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	647439	32810816	138304251	39	31860										
TDRD6	221400	broad.mit.edu	37	chr6	46657366	46657366	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agtttgttaaaaatccttctGagttttggattaggttgagg	11	3	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:46657366G>C	uc003oyj.2	+	1	1501	c.1501G>C	c.(1501-1503)GAG>CAG	p.E501Q	TDRD6_uc010jze.2_Missense_Mutation_p.E495Q	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	501					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AAATCCTTCTGAGTTTTGGAT	0.413													0	0	0	0.036044	0	45	125										C	46657366	G	C	46657366	3	2	103	1	0	0	0	0	1	0	0	0	15731	1291	45	1	1503	1	TDRD6	6	46657366	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	13846550	46657366	124457701	40	31861										
RTN4IP1	84816	broad.mit.edu	37	chr6	107067168	107067168	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atatggcaaagaggcagcttGagtatgagtgagtgatttgg	15	3	0	5			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:107067168G>C	uc003prj.2	-	4	1006	c.529C>G	c.(529-531)CAA>GAA	p.Q177E	RTN4IP1_uc010kdd.2_Missense_Mutation_p.Q177E|RTN4IP1_uc003prk.2_Missense_Mutation_p.Q77E	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	177						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		GAGGCAGCTTGAGTATGAGTG	0.413													0	0	0	0.008291	0	10	78										C	107067168	G	C	107067168	3	2	103	1	0	0	0	0	1	0	0	0	13729	1299	45	1	685	1	RTN4IP1	6	107067168	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	60409802	107067168	64047899	41	31862										
GPRC6A	222545	broad.mit.edu	37	chr6	117128203	117128203	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	taaaagtgttaagagccaatCgtccatagtcatcatctgtg	8	8	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:117128203C>T	uc003pxj.1	-	3	687	c.665G>A	c.(664-666)CGA>CAA	p.R222Q	GPRC6A_uc003pxk.1_Missense_Mutation_p.R222Q|GPRC6A_uc003pxl.1_Missense_Mutation_p.R222Q	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	222	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AAGAGCCAATCGTCCATAGTC	0.408													0	0	0	0.016723	0	13	194										T	117128203	C	T	117128203	3	4	103	1	0	0	0	0	1	0	0	0	6728	884	31	1	2131	1	GPRC6A	6	117128203	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	10061035	117128203	53986864	42	31863										
UST	10090	broad.mit.edu	37	chr6	149262491	149262491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tactgtggtcttgcttctgaGaatcttgtcggagaagcacg	12	8	3	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr6:149262491G>A	uc003qmg.2	+	3	664	c.368G>A	c.(367-369)AGA>AAA	p.R123K		NM_005715	NP_005706	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	123	Lumenal (Potential).				protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		TTGCTTCTGAGAATCTTGTCG	0.438													0	0	0	0.004482	0	9	159										A	149262491	G	A	149262491	3	1	103	1	0	0	0	0	1	0	0	0	17090	942	33	1	378	1	UST	6	149262491	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	32134288	149262491	21852576	43	31864										
FKBP14	55033	broad.mit.edu	37	chr7	30066007	30066007	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atcccctcctttggtcttgcGatggcagatgaatggcttct	10	11	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:30066007G>A	uc003tal.1	-	1	262	c.118C>T	c.(118-120)CGC>TGC	p.R40C	PLEKHA8_uc003tao.2_5'Flank|PLEKHA8_uc003tap.1_5'Flank|FKBP14_uc010kvq.1_RNA|PLEKHA8_uc003tam.1_5'Flank|PLEKHA8_uc003tan.2_5'Flank	NM_017946	NP_060416	Q9NWM8	FKB14_HUMAN	FK506 binding protein 14 precursor	40					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						TTGGTCTTGCGATGGCAGATG	0.468													0	0	0	0.004482	0	8	119										A	30066007	G	A	30066007	3	1	103	1	0	0	0	0	1	0	0	0	5904	1058	37	1	533	1	FKBP14	7	30066007	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		30066007	129072656	44	31865										
AQP1	358	broad.mit.edu	37	chr7	30962182	30962182	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtttctttccctcacagattGactacactggctgtgggatt	9	10	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:30962182G>T	uc003tbv.1	+	3	610	c.553G>T	c.(553-555)GAC>TAC	p.D185Y	AQP1_uc011kac.1_Missense_Mutation_p.D245Y|AQP1_uc010kwf.1_Missense_Mutation_p.D102Y|AQP1_uc010kwg.1_Missense_Mutation_p.D66Y|AQP1_uc010kwh.1_Missense_Mutation_p.D134Y	NM_198098	NP_932766	P29972	AQP1_HUMAN	aquaporin 1	185	Extracellular.				ammonium transport|cell volume homeostasis|cellular hyperosmotic response|cellular response to cAMP|cellular response to copper ion|cellular response to dexamethasone stimulus|cellular response to hydrogen peroxide|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to mercury ion|cellular response to nitric oxide|cellular response to retinoic acid|cellular response to salt stress|cellular response to UV|cerebrospinal fluid secretion|cGMP biosynthetic process|establishment or maintenance of actin cytoskeleton polarity|lateral ventricle development|maintenance of symbiont-containing vacuole via substance secreted by host|negative regulation of apoptosis|odontogenesis|pancreatic juice secretion|positive regulation of angiogenesis|positive regulation of fibroblast proliferation|positive regulation of saliva secretion|renal water transport|response to drug|transepithelial water transport	apical plasma membrane|basal plasma membrane|brush border membrane|cytoplasm|integral to plasma membrane|nuclear membrane|sarcolemma|symbiont-containing vacuole	ammonia transmembrane transporter activity|carbon dioxide transmembrane transporter activity|glycerol transmembrane transporter activity|intracellular cGMP activated cation channel activity|nitric oxide transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|protein binding|water channel activity				0		Melanoma(862;0.16)			Acetazolamide(DB00819)	ctcACAGATTGACTACACTGG	0.313													1	0	5.26018e-13	0.012319	5.54885e-13	19	307										T	30962182	G	T	30962182	3	4	103	1	0	0	0	0	1	0	0	0	821	1290	45	3	820	3	AQP1	7	30962182	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	896175	30962182	128176481	45	31866										
AMPH	273	broad.mit.edu	37	chr7	38431407	38431407	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cccttgcagatgctagctggTcagcagcccccatggctggt	12	14	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:38431407T>C	uc003tgu.2	-	19	1889	c.1820A>G	c.(1819-1821)GAC>GGC	p.D607G	AMPH_uc003tgv.2_Missense_Mutation_p.D565G|AMPH_uc003tgt.2_Missense_Mutation_p.D492G|AMPH_uc003tgw.1_Missense_Mutation_p.D630G|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	607					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TGCTAGCTGGTCAGCAGCCCC	0.547													0	0	0	0.02938	0	5	45										C	38431407	T	C	38431407	3	2	103	1	0	0	0	0	1	0	0	0	588	1667	58	5	279	5	AMPH	7	38431407	Missense_Mutation	SNP	T	TCGA-GC-A3OO-01A-11D-A22Z-08	7469225	38431407	120707256	46	31867										
RABGEF1	27342	broad.mit.edu	37	chr7	66240337	66240337	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	acccgcaaggttaccacagtGaagaaattcttcagtgcatc	8	11	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:66240337G>A	uc011kee.1	+	3	509	c.345G>A	c.(343-345)GTG>GTA	p.V115V	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_5'UTR|RABGEF1_uc010lag.2_Silent_p.V101V|RABGEF1_uc003tvh.2_Silent_p.V101V|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	279					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TTACCACAGTGAAGAAATTCT	0.468													0	0	0	0.021553	0	6	66										A	66240337	G	A	66240337	2	1	103	1	0	0	0	0	0	0	0	1	12966	1277	45	1		1	RABGEF1	7	66240337	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	27808930	66240337	92898326	47	31868										
TRIP6	7205	broad.mit.edu	37	chr7	100468309	100468309	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctacatgccgggcccagcttCgcggccagcatttctacgcc	10	17	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:100468309C>T	uc003uww.2	+	6	1113	c.943C>T	c.(943-945)CGC>TGC	p.R315C	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	315	LIM zinc-binding 1.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGCCCAGCTTCGCGGCCAGCA	0.617													0	0	0	0.02938	0	6	44										T	100468309	C	T	100468309	3	4	103	1	0	0	0	0	1	0	0	0	16556	884	31	1	965	1	TRIP6	7	100468309	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	34227972	100468309	58670354	48	31869										
AKR1B15	441282	broad.mit.edu	37	chr7	134260673	134260673	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ccccctgggctctccggataGaccttggtgaggcttccaag	12	14	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:134260673G>A	uc011kpr.1	+	8	1036	c.737G>A	c.(736-738)AGA>AAA	p.R246K	AKR1B15_uc011kps.1_Missense_Mutation_p.R218K	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	246							oxidoreductase activity			ovary(1)	1						TCTCCGGATAGACCTTGGTGA	0.478													0	0	0	0.009096	0	4	26										A	134260673	G	A	134260673	3	1	103	1	0	0	0	0	1	0	0	0	468	942	33	1	759	1	AKR1B15	7	134260673	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	33792364	134260673	24877990	49	31870										
CLCN1	1180	broad.mit.edu	37	chr7	143018480	143018480	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tacaagtggtcctacgcgcaGatgcagcccagccttcctct	9	15	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:143018480G>A	uc003wcr.1	+	4	543	c.456G>A	c.(454-456)CAG>CAA	p.Q152Q	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_5'UTR	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	152	Helical; (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CCTACGCGCAGATGCAGCCCA	0.617													0	0	0	0.021553	0	6	46										A	143018480	G	A	143018480	2	1	103	1	0	0	0	0	0	0	0	1	3462	933	33	1		1	CLCN1	7	143018480	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	8757807	143018480	16120183	50	31871										
FAM115C	285966	broad.mit.edu	37	chr7	143421796	143421796	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gaaacatatctacaggtactGagcagaaattctgggagaag	11	6	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:143421796G>C	uc003wdf.2	+	7	2594	c.2511G>C	c.(2509-2511)CTG>CTC	p.L837L	FAM115C_uc003wdg.2_Silent_p.L556L|FAM115C_uc011ktk.1_Silent_p.L837L|FAM115C_uc003wdh.2_Silent_p.L837L|FAM115C_uc011ktm.1_Silent_p.L837L|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|LOC154761_uc003wdj.1_Intron|FAM115C_uc011ktt.1_Intron|FAM115C_uc003wdi.1_Intron	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	Error:Variant_position_missing_in_A6NFQ2_after_alignment											0						TACAGGTACTGAGCAGAAATT	0.572													0	0	0	0.021553	0	4	35										C	143421796	G	C	143421796	2	2	103	1	0	0	0	0	0	0	0	1	5406	1277	45	1		1	FAM115C	7	143421796	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	403316	143421796	15716867	51	31872										
DPP6	1804	broad.mit.edu	37	chr7	154680984	154680984	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttgcccccgcatgtgcagatGaccaaggtagcccatcgagt	11	13	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr7:154680984G>A	uc003wlk.2	+	24	2436	c.2307G>A	c.(2305-2307)ATG>ATA	p.M769I	DPP6_uc003wli.2_Missense_Mutation_p.M705I|DPP6_uc003wlm.2_Missense_Mutation_p.M707I|DPP6_uc011kvq.1_Missense_Mutation_p.M662I	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	769	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			ATGTGCAGATGACCAAGGTAG	0.537													0	0	0	0.009096	0	4	24										A	154680984	G	A	154680984	3	1	103	1	0	0	0	0	1	0	0	0	4730	1290	45	1	2517	1	DPP6	7	154680984	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	11259188	154680984	4457679	52	31873										
PBK	55872	broad.mit.edu	37	chr8	27667830	27667830	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctgagatgatcactagacatCtgtttccagagcttcaacaa	7	10	3	4			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr8:27667830C>T	uc003xgi.2	-	8	1162	c.961G>A	c.(961-963)GAT>AAT	p.D321N	ESCO2_uc010luy.1_Intron|PBK_uc011lap.1_Missense_Mutation_p.D332N	NM_018492	NP_060962	Q96KB5	TOPK_HUMAN	PDZ binding kinase	321	PDZ-interaction.|Protein kinase.				mitosis		ATP binding|protein binding|protein serine/threonine kinase activity				0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|KIRC - Kidney renal clear cell carcinoma(542;0.101)|Kidney(114;0.121)|Colorectal(74;0.141)		CACTAGACATCTGTTTCCAGA	0.358													0	0	0	0.02938	0	7	106										T	27667830	C	T	27667830	3	4	103	1	0	0	0	0	1	0	0	0	11488	913	32	1	11	1	PBK	8	27667830	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		27667830	118696192	53	31874										
POP1	10940	broad.mit.edu	37	chr8	99148933	99148933	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agatccatgtctaccatactCttggatctctccaaccacag	5	14	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr8:99148933C>G	uc003yij.3	+	8	1335	c.1235C>G	c.(1234-1236)TCT>TGT	p.S412C	POP1_uc011lgv.1_Missense_Mutation_p.S412C|POP1_uc003yik.2_Missense_Mutation_p.S412C	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	412					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CTACCATACTCTTGGATCTCT	0.358													0	0	0	0.00308	0	8	67										G	99148933	C	G	99148933	3	3	103	1	0	0	0	0	1	0	0	0	12251	913	32	1	1261	1	POP1	8	99148933	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	71481103	99148933	47215089	54	31875										
FER1L6	654463	broad.mit.edu	37	chr8	125113410	125113410	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tccctgactggagagggcaaCttcaactggcgcttcctgtt	11	12	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr8:125113410C>T	uc003yqw.2	+	38	5162	c.4956C>T	c.(4954-4956)AAC>AAT	p.N1652N	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1652	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAGAGGGCAACTTCAACTGGC	0.433													0	0	0	0.006214	0	9	79										T	125113410	C	T	125113410	2	4	103	1	0	0	0	0	0	0	0	1	5815	564	20	2		2	FER1L6	8	125113410	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	25964477	125113410	21250612	55	31876										
ST3GAL1	6482	broad.mit.edu	37	chr8	134477108	134477108	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ggatcatgctgacattatctCccagctcccggaagctctca	8	14	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr8:134477108C>T	uc003yuk.2	-	7	1425	c.596G>A	c.(595-597)GGA>GAA	p.G199E	ST3GAL1_uc003yum.2_Missense_Mutation_p.G199E	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	199	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			GACATTATCTCCCAGCTCCCG	0.582													0	0	0	0.024245	0	14	145										T	134477108	C	T	134477108	3	4	103	1	0	0	0	0	1	0	0	0	15213	855	30	1	442	1	ST3GAL1	8	134477108	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	9363698	134477108	11886914	56	31877										
UBAP2	55833	broad.mit.edu	37	chr9	33998823	33998823	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aaaatctgaatcattcttatCaaagatcacttgagcgagac	6	8	5	4			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:33998823C>G	uc003ztq.1	-	3	252	c.139G>C	c.(139-141)GAT>CAT	p.D47H	UBAP2_uc011loc.1_Missense_Mutation_p.D9H|UBAP2_uc011lod.1_5'UTR|UBAP2_uc011loe.1_Missense_Mutation_p.D9H|UBAP2_uc011lof.1_Missense_Mutation_p.D9H|UBAP2_uc011log.1_Missense_Mutation_p.D46H|UBAP2_uc003ztr.2_Missense_Mutation_p.D9H	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	47										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TCATTCTTATCAAAGATCACT	0.328													0	0	0	0.0333	0	16	93										G	33998823	C	G	33998823	3	3	103	1	0	0	0	0	1	0	0	0	16834	826	29	1	3328	1	UBAP2	9	33998823	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		33998823	107214608	57	31878										
VCP	7415	broad.mit.edu	37	chr9	35062058	35062058	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttggttgctgccataacaatCacatgtgccctctgctttag	8	11	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:35062058C>T	uc003zvy.2	-	9	1412	c.1023G>A	c.(1021-1023)GTG>GTA	p.V341V	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Silent_p.V10V|VCP_uc010mki.1_Silent_p.V296V	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	341					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCATAACAATCACATGTGCCC	0.527													0	0	0	0.016723	0	14	85										T	35062058	C	T	35062058	2	4	103	1	0	0	0	0	0	0	0	1	17137	813	29	1		1	VCP	9	35062058	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	1063235	35062058	106151373	58	31879										
TLN1	7094	broad.mit.edu	37	chr9	35716479	35716479	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctccagatcactttccccctCagcatcagccttgatggcat	6	16	3	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:35716479C>T	uc003zxt.2	-	20	2887	c.2533G>A	c.(2533-2535)GAG>AAG	p.E845K		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	845					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTTTCCCCCTCAGCATCAGCC	0.572													0	0	0	0.004482	0	9	138										T	35716479	C	T	35716479	3	4	103	1	0	0	0	0	1	0	0	0	15944	835	29	1	5244	1	TLN1	9	35716479	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	654421	35716479	105496952	59	31880										
TRPM3	80036	broad.mit.edu	37	chr9	73235278	73235278	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tcctcgcctcaagggaatatCatcctgtaattacagggaaa	8	10	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:73235278C>T	uc004aid.2	-	15	2051	c.1807G>A	c.(1807-1809)GAT>AAT	p.D603N	TRPM3_uc004ahu.2_Missense_Mutation_p.D433N|TRPM3_uc004ahv.2_Missense_Mutation_p.D405N|TRPM3_uc004ahw.2_Missense_Mutation_p.D475N|TRPM3_uc004ahx.2_Missense_Mutation_p.D462N|TRPM3_uc004ahy.2_Missense_Mutation_p.D465N|TRPM3_uc004ahz.2_Missense_Mutation_p.D452N|TRPM3_uc004aia.2_Missense_Mutation_p.D450N|TRPM3_uc004aib.2_Missense_Mutation_p.D440N|TRPM3_uc004aic.2_Missense_Mutation_p.D603N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	628	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AAGGGAATATCATCCTGTAAT	0.318													0	0	0	0.010504	0	20	209										T	73235278	C	T	73235278	3	4	103	1	0	0	0	0	1	0	0	0	16584	826	29	1	3360	1	TRPM3	9	73235278	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	37518799	73235278	67978153	60	31881										
FLJ46321	389763	broad.mit.edu	37	chr9	84606383	84606383	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aatgttatctctaggtggctCtggtgggtcatccacctctg	11	10	4	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:84606383C>T	uc004amn.2	+	4	1045	c.998C>T	c.(997-999)TCT>TTT	p.S333F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	333						integral to membrane					0						CTAGGTGGCTCTGGTGGGTCA	0.483													0	0	0	0.008291	0	9	161										T	84606383	C	T	84606383	3	4	103	1	0	0	0	0	1	0	0	0	5932	913	32	1	1012	1	FLJ46321	9	84606383	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	11371105	84606383	56607048	61	31882										
TTC16	158248	broad.mit.edu	37	chr9	130479144	130479144	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atgccctgaaggttgaccagGgcccctcacgggacatccca	11	15	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:130479144G>A	uc004brq.1	+	2	107	c.40G>A	c.(40-42)GGC>AGC	p.G14S	PTRH1_uc004brm.2_5'Flank|PTRH1_uc004bro.2_5'Flank|PTRH1_uc010mxm.2_5'UTR|PTRH1_uc011mah.1_5'UTR|TTC16_uc011mai.1_Missense_Mutation_p.G14S|TTC16_uc004brr.1_5'Flank	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	14							binding				0						GGTTGACCAGGGCCCCTCACG	0.602													0	0	0	0.00308	0	7	43										A	130479144	G	A	130479144	3	1	103	1	0	0	0	0	1	0	0	0	16680	1232	43	2	46	2	TTC16	9	130479144	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	45872761	130479144	10734287	62	31883										
COL5A1	1289	broad.mit.edu	37	chr9	137655583	137655583	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agggggctgcctggggagccCgtaagtctgtgagctgagtg	19	8	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr9:137655583C>T	uc004cfe.2	+	20	2416	c.2034C>T	c.(2032-2034)CCC>CCT	p.P678P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	678	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTGGGGAGCCCGTAAGTCTGT	0.587													0	0	0	0.00308	0	8	78										T	137655583	C	T	137655583	2	4	103	1	0	0	0	0	0	0	0	1	3696	666	23	2		2	COL5A1	9	137655583	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	7176439	137655583	3557848	63	31884										
IL15RA	3601	broad.mit.edu	37	chr10	5995118	5995118	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctgctggtcccccaagtcacCggcagagcctccatggcttc	10	17	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr10:5995118C>T	uc001iiv.2	-	7	826	c.744G>A	c.(742-744)CCG>CCA	p.P248P	IL15RA_uc001iiu.2_Intron|IL15RA_uc010qau.1_Silent_p.P215P|IL15RA_uc001iiw.2_Silent_p.P212P|IL15RA_uc001iix.2_Silent_p.P179P|IL15RA_uc001iiy.2_Silent_p.P96P	NM_002189	NP_002180	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha isoform 1	248	Cytoplasmic (Potential).				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity				0						CCCAAGTCACCGGCAGAGCCT	0.557													0	0	0	0.013537	0	12	82										T	5995118	C	T	5995118	2	4	103	1	0	0	0	0	0	0	0	1	7632	639	23	2		2	IL15RA	10	5995118	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		5995118	129539629	64	31885										
ERCC6	2074	broad.mit.edu	37	chr10	50708622	50708622	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtcctgatcttgctgtagctCagacctgccaagaaggcaat	10	11	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr10:50708622C>G	uc001jhs.3	-	7	1801	c.1647G>C	c.(1645-1647)CTG>CTC	p.L549L	ERCC6_uc010qgr.1_5'UTR|ERCC6_uc001jhr.3_5'UTR	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	549	Helicase ATP-binding.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TGCTGTAGCTCAGACCTGCCA	0.483								Direct_reversal_of_damage|NER					0	0	0	0.020292	0	13	114										G	50708622	C	G	50708622	2	3	103	1	0	0	0	0	0	0	0	1	5217	813	29	1		1	ERCC6	10	50708622	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	44713504	50708622	84826125	65	31886										
SRGN	5552	broad.mit.edu	37	chr10	70863778	70863778	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	accaactagtagacgaaagtGatgctttccatgacaacctt	7	10	0	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr10:70863778G>A	uc001joz.2	+	3	465	c.379G>A	c.(379-381)GAT>AAT	p.D127N		NM_002727	NP_002718	P10124	SRGN_HUMAN	serglycin precursor	127					apoptosis|biomineral tissue development|maintenance of granzyme B location in T cell secretory granule|maintenance of protease location in mast cell secretory granule|negative regulation of bone mineralization|negative regulation of cytokine secretion|platelet activation|platelet degranulation|protein maturation by peptide bond cleavage	extracellular space|mast cell granule|platelet alpha granule lumen					0						AGACGAAAGTGATGCTTTCCA	0.483													0	0	0	0.00308	0	8	90										A	70863778	G	A	70863778	3	1	103	1	0	0	0	0	1	0	0	0	15147	1290	45	1	389	1	SRGN	10	70863778	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	20155156	70863778	64670969	66	31887										
H2AFY2	55506	broad.mit.edu	37	chr10	71871382	71871382	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aacgtgtacttcctgctcttCgacagcgagagcatcggcat	10	12	1	1	rs145574275	byFrequency	TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr10:71871382C>T	uc001jqm.2	+	9	1521	c.1062C>T	c.(1060-1062)TTC>TTT	p.F354F	H2AFY2_uc001jqn.2_RNA|AIFM2_uc010qjg.1_Intron	NM_018649	NP_061119	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	354	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			skin(1)	1						TCCTGCTCTTCGACAGCGAGA	0.602													0	0	0	0.008291	0	11	46										T	71871382	C	T	71871382	2	4	103	1	0	0	0	0	0	0	0	1	6930	883	31	1		1	H2AFY2	10	71871382	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	1007604	71871382	63663365	67	31888										
MRGPRX2	117194	broad.mit.edu	37	chr11	19077358	19077358	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ggccagactggacccacagaGaaccatgaataaaaaaatca	8	10	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:19077358G>A	uc001mph.2	-	2	680	c.592C>T	c.(592-594)CTC>TTC	p.L198F		NM_054030	NP_473371	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	198	Helical; Name=5; (Potential).				sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			ovary(1)	1						GACCCACAGAGAACCATGAAT	0.517													0	0	0	0.02938	0	7	63										A	19077358	G	A	19077358	3	1	103	1	0	0	0	0	1	0	0	0	9767	942	33	1	404	1	MRGPRX2	11	19077358	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		19077358	115929158	68	31889										
CELF1	10658	broad.mit.edu	37	chr11	47493803	47493803	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cagtagggcttgctgtcattCttcgaacgtttgagctgcac	11	10	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:47493803C>T	uc001nfl.2	-	12	1450	c.1440G>A	c.(1438-1440)AAG>AAA	p.K480K	CELF1_uc001nfk.1_5'Flank|CELF1_uc001nfm.2_Silent_p.K477K|CELF1_uc001nfn.2_Silent_p.K476K|CELF1_uc001nfo.1_Silent_p.K506K|CELF1_uc010rhm.1_Silent_p.K479K|CELF1_uc001nfp.2_Silent_p.K508K|CELF1_uc001nfq.1_Silent_p.K480K|CELF1_uc001nfr.1_Silent_p.K480K	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	480					embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						TGCTGTCATTCTTCGAACGTT	0.527													0	0	0	0.0333	0	18	270										T	47493803	C	T	47493803	2	4	103	1	0	0	0	0	0	0	0	1	3215	912	32	1		1	CELF1	11	47493803	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	28416445	47493803	87512713	69	31890										
OR4X2	119764	broad.mit.edu	37	chr11	48267202	48267202	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttctcaaacttgcctgctctGacaccttcctcattggtctg	6	14	4	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:48267202G>A	uc001ngs.1	+	1	547	c.547G>A	c.(547-549)GAC>AAC	p.D183N		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCCTGCTCTGACACCTTCCT	0.483													0	0	0	0.028581	0	15	266										A	48267202	G	A	48267202	3	1	103	1	0	0	0	0	1	0	0	0	11085	1290	45	1	549	1	OR4X2	11	48267202	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	773399	48267202	86739314	70	31891										
OR5D18	219438	broad.mit.edu	37	chr11	55587678	55587678	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctactctccctttcttgctcTgatacttacatcaaccagtg	4	14	4	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:55587678T>A	uc010rin.1	+	1	573	c.573T>A	c.(571-573)TCT>TCA	p.S191S		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TTTCTTGCTCTGATACTTACA	0.398													0	0	0	0.0333	0	16	133										A	55587678	T	A	55587678	2	1	103	1	0	0	0	0	0	0	0	1	11157	1567	55	5		5	OR5D18	11	55587678	Silent	SNP	T	TCGA-GC-A3OO-01A-11D-A22Z-08	7320476	55587678	79418838	71	31892										
OR5M1	390168	broad.mit.edu	37	chr11	56380343	56380343	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agataggacagaagaatgatGaagagagagcttgagagatt	14	2	0	9			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:56380343G>A	uc001nja.1	-	1	636	c.636C>T	c.(634-636)TTC>TTT	p.F212F		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GAAGAATGATGAAGAGAGAGC	0.473													0	0	0	0.028581	0	16	98										A	56380343	G	A	56380343	2	1	103	1	0	0	0	0	0	0	0	1	11172	1281	45	1		1	OR5M1	11	56380343	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	792665	56380343	78626173	72	31893										
ATG2A	23130	broad.mit.edu	37	chr11	64669802	64669802	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tcggccaggtcacgctggttGatgagggccgtctccactgg	15	12	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:64669802G>C	uc001obx.2	-	28	3949	c.3834C>G	c.(3832-3834)ATC>ATG	p.I1278M	ATG2A_uc001obw.2_Missense_Mutation_p.I43M	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1278							protein binding			ovary(1)|central_nervous_system(1)	2						CACGCTGGTTGATGAGGGCCG	0.672													0	0	0	0.004672	0	3	18										C	64669802	G	C	64669802	3	2	103	1	0	0	0	0	1	0	0	0	1093	1280	45	1	2038	1	ATG2A	11	64669802	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	8289459	64669802	70336714	73	31894										
C11orf30	56946	broad.mit.edu	37	chr11	76171016	76171016	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cacaagtaccacgtcaacccCaacctctacccctgttccaa	3	19	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:76171016C>T	uc001oxl.2	+	6	601	c.458C>T	c.(457-459)CCA>CTA	p.P153L	C11orf30_uc001oxk.2_3'UTR|C11orf30_uc009yuj.1_Missense_Mutation_p.P168L|C11orf30_uc010rsa.1_Intron|C11orf30_uc001oxm.2_Missense_Mutation_p.P154L|C11orf30_uc010rsb.1_Missense_Mutation_p.P168L|C11orf30_uc010rsc.1_Missense_Mutation_p.P168L|C11orf30_uc001oxn.2_Missense_Mutation_p.P154L|C11orf30_uc010rsd.1_Missense_Mutation_p.P167L	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	153	Interaction with BRCA2.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						ACGTCAACCCCAACCTCTACC	0.458													0	0	0	0.012213	0	33	179										T	76171016	C	T	76171016	3	4	103	1	0	0	0	0	1	0	0	0	1636	594	21	2	476	2	C11orf30	11	76171016	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	11501214	76171016	58835500	74	31895										
GUCY1A2	2977	broad.mit.edu	37	chr11	106558346	106558346	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttttattctcgacgaagaaaGagaaggctttggtggctttg	12	5	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:106558346G>C	uc001pjg.1	-	8	2518	c.2128C>G	c.(2128-2130)CTT>GTT	p.L710V	GUCY1A2_uc010rvo.1_Missense_Mutation_p.L731V|GUCY1A2_uc009yxn.1_Missense_Mutation_p.L741V	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	710					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GACGAAGAAAGAGAAGGCTTT	0.488													0	0	0	0.024245	0	16	154										C	106558346	G	C	106558346	3	2	103	1	0	0	0	0	1	0	0	0	6893	942	33	1	74	1	GUCY1A2	11	106558346	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	30387330	106558346	28448170	75	31896										
FDXACB1	91893	broad.mit.edu	37	chr11	111746739	111746739	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aagggtaggaacacttcagcCtttttagcgggaaaactttg	11	7	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:111746739C>A	uc001pmc.3	-	5	1079	c.782G>T	c.(781-783)AGG>ATG	p.R261M	ALG9_uc010rwo.1_Intron|FDXACB1_uc009yyi.2_Missense_Mutation_p.R112M	NM_138378	NP_612387	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain	261					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0						ACACTTCAGCCTTTTTAGCGG	0.423													1	0	1.67942e-08	0.006122	1.75023e-08	19	108										A	111746739	C	A	111746739	3	1	103	1	0	0	0	0	1	0	0	0	5806	681	24	4	1096	4	FDXACB1	11	111746739	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	5188393	111746739	23259777	76	31897										
NLRX1	79671	broad.mit.edu	37	chr11	119045225	119045225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tccccagcaagtacgtgggcCgctatggtgagatctgcggt	14	11	1	1	rs149154497		TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr11:119045225C>T	uc001pvu.2	+	6	1128	c.913C>T	c.(913-915)CGC>TGC	p.R305C	NLRX1_uc010rzc.1_Missense_Mutation_p.R127C|NLRX1_uc001pvv.2_Missense_Mutation_p.R305C|NLRX1_uc001pvw.2_Missense_Mutation_p.R305C|NLRX1_uc001pvx.2_Missense_Mutation_p.R305C	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	305	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTACGTGGGCCGCTATGGTGA	0.567													0	0	0	0.010729	0	12	194										T	119045225	C	T	119045225	3	4	103	1	0	0	0	0	1	0	0	0	10485	652	23	2	931	2	NLRX1	11	119045225	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	7298486	119045225	15961291	77	31898										
PZP	5858	broad.mit.edu	37	chr12	9313698	9313698	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gagcttcaaggacaactgctCagacacattagcacctttag	8	11	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:9313698C>G	uc001qvl.2	-	23	2832	c.2803G>C	c.(2803-2805)GAG>CAG	p.E935Q	PZP_uc009zgl.2_Missense_Mutation_p.E721Q|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Silent_p.L166L	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GACAACTGCTCAGACACATTA	0.353													0	0	0	0.010818	0	31	86										G	9313698	C	G	9313698	3	3	103	1	0	0	0	0	1	0	0	0	12869	835	29	1	1701	1	PZP	12	9313698	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		9313698	124538197	78	31899										
RECQL	5965	broad.mit.edu	37	chr12	21624476	21624476	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctgcaccctttcccatccaaGaatcaatcagtttcaatgga	5	13	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:21624476G>A	uc001rex.2	-	14	1901	c.1553C>T	c.(1552-1554)TCT>TTT	p.S518F	RECQL_uc001rey.2_Missense_Mutation_p.S518F	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	518					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TCCCATCCAAGAATCAATCAG	0.423								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.028581	0	16	159										A	21624476	G	A	21624476	3	1	103	1	0	0	0	0	1	0	0	0	13201	942	33	1	408	1	RECQL	12	21624476	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	12310778	21624476	112227419	79	31900										
DENND5B	160518	broad.mit.edu	37	chr12	31604940	31604940	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atgtcctgggcagtctgaatGacaaatgcttcgtaatctgc	10	9	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:31604940G>A	uc001rki.1	-	5	1749	c.1563C>T	c.(1561-1563)GTC>GTT	p.V521V	DENND5B_uc001rkh.1_Silent_p.V556V|DENND5B_uc009zjq.1_Intron|DENND5B_uc001rkj.2_Silent_p.V543V|DENND5B_uc001rkk.1_Silent_p.V443V	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	521	dDENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						CAGTCTGAATGACAAATGCTT	0.443													0	0	0	0.010729	0	11	103										A	31604940	G	A	31604940	2	1	103	1	0	0	0	0	0	0	0	1	4437	1277	45	1		1	DENND5B	12	31604940	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	9980464	31604940	102246955	80	31901										
SPATS2	65244	broad.mit.edu	37	chr12	49883353	49883353	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aaacagtacaagcattcatgGaaggtaatcctgacttaatt	7	7	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:49883353G>A	uc001rud.2	+	5	1200	c.211G>A	c.(211-213)GAA>AAA	p.E71K	SPATS2_uc001rue.2_RNA|SPATS2_uc009zli.1_Missense_Mutation_p.E71K|SPATS2_uc001ruf.2_Missense_Mutation_p.E71K|SPATS2_uc001rug.2_Missense_Mutation_p.E71K	NM_023071	NP_075559	Q86XZ4	SPAS2_HUMAN	spermatogenesis associated, serine-rich 2	71						cytoplasm				breast(1)	1						AGCATTCATGGAAGGTAATCC	0.328													0	0	0	0.008291	0	10	43										A	49883353	G	A	49883353	3	1	103	1	0	0	0	0	1	0	0	0	15018	1175	41	1	221	1	SPATS2	12	49883353	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	18278413	49883353	83968542	81	31902										
KRT79	338785	broad.mit.edu	37	chr12	53225239	53225239	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cacgttcctgagctctgagtCcagcctcccccgctcgctct	8	19	2	2	rs140032117	byFrequency	TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:53225239C>A	uc001sbb.2	-	2	682	c.649G>T	c.(649-651)GAC>TAC	p.D217Y	KRT79_uc001sba.2_5'Flank	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	217	Rod.|Coil 1B.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						AGCTCTGAGTCCAGCCTCCCC	0.622													1	0	2.09667e-21	0.017118	2.25294e-21	31	115										A	53225239	C	A	53225239	3	1	103	1	0	0	0	0	1	0	0	0	8492	855	30	3	990	3	KRT79	12	53225239	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	3341886	53225239	80626656	82	31903										
NCKAP1L	3071	broad.mit.edu	37	chr12	54901657	54901657	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gatcatgtatatgaacttctCaacaccattgatgcctgcca	6	11	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:54901657C>G	uc001sgc.3	+	4	406	c.327C>G	c.(325-327)CTC>CTG	p.L109L	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Silent_p.L59L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	109					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ATGAACTTCTCAACACCATTG	0.423													0	0	0	0.01441	0	42	158										G	54901657	C	G	54901657	2	3	103	1	0	0	0	0	0	0	0	1	10222	813	29	1		1	NCKAP1L	12	54901657	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	1676418	54901657	78950238	83	31904										
CDK2	1017	broad.mit.edu	37	chr12	56361840	56361840	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tttccttctctaggctgctgGatgtcattcacacagaaaat	7	10	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:56361840G>A	uc001sit.3	+	3	439	c.202G>A	c.(202-204)GAT>AAT	p.D68N	CDK2_uc001siu.3_Missense_Mutation_p.D68N|CDK2_uc010spy.1_Missense_Mutation_p.D42N	NM_001798	NP_001789	P24941	CDK2_HUMAN	cyclin-dependent kinase 2 isoform 1	68	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|blood coagulation|cell division|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA replication|G1/S transition of mitotic cell cycle|G2 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|histone phosphorylation|M/G1 transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation|Ras protein signal transduction|regulation of DNA replication|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol	ATP binding|cyclin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2			UCEC - Uterine corpus endometrioid carcinoma (6;0.123)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			TAGGCTGCTGGATGTCATTCA	0.443													0	0	0	0.024245	0	16	104										A	56361840	G	A	56361840	3	1	103	1	0	0	0	0	1	0	0	0	3136	1174	41	1	212	1	CDK2	12	56361840	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	1460183	56361840	77490055	84	31905										
POLR3B	55703	broad.mit.edu	37	chr12	106820980	106820980	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tttttttttttttagcttttAtctcttctttttgaagactt	3	5	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:106820980A>T	uc001tlp.2	+	13	1329	c.1107A>T	c.(1105-1107)TTA>TTT	p.L369F	POLR3B_uc001tlq.2_Missense_Mutation_p.L311F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	369					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTAGCTTTTATCTCTTCTTT	0.269													0	0	0	0.00308	0	6	12										T	106820980	A	T	106820980	3	4	103	1	0	0	0	0	1	0	0	0	12229	446	16	5	1157	5	POLR3B	12	106820980	Missense_Mutation	SNP	A	TCGA-GC-A3OO-01A-11D-A22Z-08	50459140	106820980	27030915	85	31906										
TCTN1	79600	broad.mit.edu	37	chr12	111072480	111072480	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gttaatgatttctagcgtttCtggtgaaccaggctgttaag	11	6	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:111072480C>T	uc009zvs.2	+	6	826	c.718C>T	c.(718-720)CTG>TTG	p.L240L	TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Silent_p.L180L|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Intron|TCTN1_uc001trn.3_Silent_p.L240L|TCTN1_uc001trj.1_Silent_p.L184L|TCTN1_uc001trk.3_RNA|HVCN1_uc001trq.1_Intron	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	240					multicellular organismal development	extracellular region					0						TCTAGCGTTTCTGGTGAACCA	0.343													0	0	0	0.009096	0	4	20										T	111072480	C	T	111072480	2	4	103	1	0	0	0	0	0	0	0	1	15719	912	32	1		1	TCTN1	12	111072480	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	4251500	111072480	22779415	86	31907										
CUX2	23316	broad.mit.edu	37	chr12	111785494	111785494	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agccaaccgtgaaggaactgGagcttcaggagggccctgag	15	10	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr12:111785494G>C	uc001tsa.1	+	22	3979	c.3826G>C	c.(3826-3828)GAG>CAG	p.E1276Q		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1276						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GAAGGAACTGGAGCTTCAGGA	0.617													0	0	0	0.006214	0	10	66										C	111785494	G	C	111785494	3	2	103	1	0	0	0	0	1	0	0	0	4065	1175	41	1	3912	1	CUX2	12	111785494	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	713014	111785494	22066401	87	31908										
SUPT16H	11198	broad.mit.edu	37	chr14	21852042	21852042	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cgccaattgctgtacagtctCttcactcgccgataataagc	7	13	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr14:21852042C>T	uc001wao.2	-	1	384	c.45G>A	c.(43-45)AAG>AAA	p.K15K	SUPT16H_uc001wap.2_Silent_p.K15K|SUPT16H_uc001waq.1_Silent_p.K15K	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	15					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TGTACAGTCTCTTCACTCGCC	0.547													0	0	0	0.006214	0	8	74										T	21852042	C	T	21852042	2	4	103	1	0	0	0	0	0	0	0	1	15393	912	32	1		1	SUPT16H	14	21852042	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		21852042	85497498	88	31909										
SMEK1	55671	broad.mit.edu	37	chr14	91937257	91937257	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tccttattaataatgtagttCtttatgtggtaggtatggtg	10	3	1	0	rs148837810		TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr14:91937257C>G	uc001xzn.2	-	10	2406	c.1584G>C	c.(1582-1584)AAG>AAC	p.K528N	SMEK1_uc001xzm.2_Missense_Mutation_p.K515N|SMEK1_uc001xzo.2_Missense_Mutation_p.K515N|SMEK1_uc010atz.2_Missense_Mutation_p.K289N|SMEK1_uc001xzp.1_RNA	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	528						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		TAATGTAGTTCTTTATGTGGT	0.358													0	0	0	0.007413	0	18	65										G	91937257	C	G	91937257	3	3	103	1	0	0	0	0	1	0	0	0	14793	912	32	1	941	1	SMEK1	14	91937257	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	70085215	91937257	15412283	89	31910										
SMEK1	55671	broad.mit.edu	37	chr14	91937337	91937337	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tagttgggcagtctgaaaatCatctaaaagaaacaaaacac	7	7	3	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr14:91937337C>T	uc001xzn.2	-	10	2326	c.1504G>A	c.(1504-1506)GAT>AAT	p.D502N	SMEK1_uc001xzm.2_Missense_Mutation_p.D489N|SMEK1_uc001xzo.2_Missense_Mutation_p.D489N|SMEK1_uc010atz.2_Missense_Mutation_p.D263N|SMEK1_uc001xzp.1_RNA	NM_032560	NP_115949	Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1	502						microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		GTCTGAAAATCATCTAAAAGA	0.289													0	0	0	0.020292	0	11	47										T	91937337	C	T	91937337	3	4	103	1	0	0	0	0	1	0	0	0	14793	826	29	1	1021	1	SMEK1	14	91937337	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	80	91937337	15412203	90	31911										
RIN3	79890	broad.mit.edu	37	chr14	93125804	93125804	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atctacgactccatggccctCggcaacccaggtcagtgggc	11	15	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr14:93125804C>G	uc001yap.2	+	7	2477	c.2325C>G	c.(2323-2325)CTC>CTG	p.L775L	RIN3_uc010auk.2_Silent_p.L437L|RIN3_uc001yaq.2_Silent_p.L700L|RIN3_uc001yar.1_Silent_p.L437L|RIN3_uc001yas.1_Silent_p.L437L	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	775	VPS9.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CCATGGCCCTCGGCAACCCAG	0.582													0	0	0	0.008291	0	9	76										G	93125804	C	G	93125804	2	3	103	1	0	0	0	0	0	0	0	1	13373	871	31	1		1	RIN3	14	93125804	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	1188467	93125804	14223736	91	31912										
IQCH	64799	broad.mit.edu	37	chr15	67793052	67793052	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aagaggagcaacagtccaaaGatgataaaaacctctctaaa	7	8	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr15:67793052G>A	uc002aqo.1	+	21	3099	c.3052G>A	c.(3052-3054)GAT>AAT	p.D1018N	IQCH_uc002aqq.1_Missense_Mutation_p.D675N|IQCH_uc002aqp.1_3'UTR|uc002aqr.1_Intron	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	1018										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		ACAGTCCAAAGATGATAAAAA	0.328													0	0	0	0.00308	0	7	57										A	67793052	G	A	67793052	3	1	103	1	0	0	0	0	1	0	0	0	7811	942	33	1	3262	1	IQCH	15	67793052	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		67793052	34738340	92	31913										
LBXCOR1	390598	broad.mit.edu	37	chr15	68118511	68118511	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aagaactacagctataatgaGatccacaaccgccgcgtggc	9	12	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr15:68118511G>A	uc002aqy.1	+	2	318	c.318G>A	c.(316-318)GAG>GAA	p.E106E		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	115					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						GCTATAATGAGATCCACAACC	0.632													0	0	0	0.010729	0	10	80										A	68118511	G	A	68118511	2	1	103	1	0	0	0	0	0	0	0	1	8655	933	33	1		1	LBXCOR1	15	68118511	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	325459	68118511	34412881	93	31914										
SPESP1	246777	broad.mit.edu	37	chr15	69238236	69238236	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cacacggaaagtaccccattCtggtcgatcaaaccaaacaa	6	13	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr15:69238236C>G	uc002arn.1	+	2	491	c.363C>G	c.(361-363)TTC>TTG	p.F121L	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	121					multicellular organismal development	acrosomal vesicle					0						GTACCCCATTCTGGTCGATCA	0.428													0	0	0	0.013537	0	11	70										G	69238236	C	G	69238236	3	3	103	1	0	0	0	0	1	0	0	0	15039	912	32	1	369	1	SPESP1	15	69238236	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	1119725	69238236	33293156	94	31915										
PARP6	56965	broad.mit.edu	37	chr15	72552921	72552921	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	aacacttccactttggggttCttcatggtacaggagatgga	11	8	2	1	rs28625945		TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr15:72552921C>T	uc002auc.2	-	9	1113	c.654G>A	c.(652-654)AAG>AAA	p.K218K	PARP6_uc002aua.2_Silent_p.K83K|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Silent_p.K218K	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	218							NAD+ ADP-ribosyltransferase activity				0						CTTTGGGGTTCTTCATGGTAC	0.582													0	0	0	0.01441	0	69	442										T	72552921	C	T	72552921	2	4	103	1	0	0	0	0	0	0	0	1	11464	912	32	1		1	PARP6	15	72552921	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	3314685	72552921	29978471	95	31916										
ISLR2	57611	broad.mit.edu	37	chr15	74425216	74425216	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tcgcggactgcgcttacaaaGagttgcgtgaggtgccggaa	15	9	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr15:74425216G>C	uc002axd.2	+	4	890	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	ISLR2_uc002axe.2_Missense_Mutation_p.E41Q|ISLR2_uc010bjg.2_Missense_Mutation_p.E41Q|ISLR2_uc010bjf.2_Missense_Mutation_p.E41Q	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	41	Extracellular (Potential).|LRRNT.				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CGCTTACAAAGAGTTGCGTGA	0.637													0	0	0	0.010729	0	10	89										C	74425216	G	C	74425216	3	2	103	1	0	0	0	0	1	0	0	0	7859	943	33	1	123	1	ISLR2	15	74425216	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	1872295	74425216	28106176	96	31917										
SRCAP	10847	broad.mit.edu	37	chr16	30731577	30731577	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gccccggcaccgcctctctcGccgggtactgttagaagtgg	13	15	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr16:30731577G>T	uc002dze.1	+	19	3297	c.2912G>T	c.(2911-2913)CGC>CTC	p.R971L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R828L|SRCAP_uc010bzz.1_Missense_Mutation_p.R541L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	971					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CGCCTCTCTCGCCGGGTACTG	0.567													1	0	5.44703e-19	0.036044	5.81689e-19	43	212										T	30731577	G	T	30731577	3	4	103	1	0	0	0	0	1	0	0	0	15134	1087	38	4	2978	4	SRCAP	16	30731577	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		30731577	59623176	97	31918										
TMCO7	79613	broad.mit.edu	37	chr16	68901008	68901008	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	acagatgtgaagacacagatGaggtgtcgggccccagcttg	14	9	0	5			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr16:68901008G>A	uc002ewi.3	+	4	891	c.879G>A	c.(877-879)ATG>ATA	p.M293I	TMCO7_uc002ewh.2_Missense_Mutation_p.M293I	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	293						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		AGACACAGATGAGGTGTCGGG	0.502													0	0	0	0.008291	0	11	109										A	68901008	G	A	68901008	3	1	103	1	0	0	0	0	1	0	0	0	15998	1290	45	1	893	1	TMCO7	16	68901008	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	38169431	68901008	21453745	98	31919										
SDR42E1	93517	broad.mit.edu	37	chr16	82033729	82033729	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtcagacaggtggcggatgtCtccttgtataaacttgattc	11	8	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr16:82033729C>G	uc002fgu.2	-	3	297	c.169G>C	c.(169-171)GAC>CAC	p.D57H		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	57					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						TGGCGGATGTCTCCTTGTATA	0.498													0	0	0	0.020292	0	13	156										G	82033729	C	G	82033729	3	3	103	1	0	0	0	0	1	0	0	0	13973	913	32	1	1016	1	SDR42E1	16	82033729	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	13132721	82033729	8321024	99	31920										
SMYD4	114826	broad.mit.edu	37	chr17	1704306	1704306	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgtctgtgctctgttaatgtCtttaagacacgtctgaaaac	8	8	4	2	rs151287405		TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:1704306C>T	uc002ftm.3	-	5	550	c.382G>A	c.(382-384)GAC>AAC	p.D128N	SMYD4_uc002ftn.1_5'UTR	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	128							zinc ion binding			skin(3)|kidney(2)	5						CTGTTAATGTCTTTAAGACAC	0.418													0	0	0	0.020292	0	14	137										T	1704306	C	T	1704306	3	4	103	1	0	0	0	0	1	0	0	0	14824	913	32	1	2060	1	SMYD4	17	1704306	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		1704306	79490904	100	31921										
P2RX1	5023	broad.mit.edu	37	chr17	3801112	3801112	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agttggggcccgagcatcagGatgtcctcatgttctcctgc	12	12	3	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:3801112G>C	uc002fww.2	-	12	1637	c.1196C>G	c.(1195-1197)TCC>TGC	p.S399C		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	399	Cytoplasmic (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CGAGCATCAGGATGTCCTCAT	0.642													0	0	0	0.006214	0	8	17										C	3801112	G	C	3801112	3	2	103	1	0	0	0	0	1	0	0	0	11339	1174	41	1	7	1	P2RX1	17	3801112	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	2096806	3801112	77394098	101	31922										
ZZEF1	23140	broad.mit.edu	37	chr17	3954291	3954291	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cctctgccggtcactgatccGaatggttaccattgggtggg	13	11	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:3954291G>A	uc002fxe.2	-	36	5711	c.5647C>T	c.(5647-5649)CGG>TGG	p.R1883W	ZZEF1_uc002fxh.2_Missense_Mutation_p.R197W|ZZEF1_uc002fxi.2_Missense_Mutation_p.R118W|ZZEF1_uc002fxj.1_Missense_Mutation_p.R496W	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1883							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCACTGATCCGAATGGTTACC	0.532													0	0	0	0.016522	0	23	49										A	3954291	G	A	3954291	3	1	103	1	0	0	0	0	1	0	0	0	18252	1057	37	1	3318	1	ZZEF1	17	3954291	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	153179	3954291	77240919	102	31923										
ZZEF1	23140	broad.mit.edu	37	chr17	3977490	3977490	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgggaagccaggcgtcccatCagccgggagacgaggagctg	17	11	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:3977490C>T	uc002fxe.2	-	24	3703	c.3639G>A	c.(3637-3639)CTG>CTA	p.L1213L		NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1213							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGCGTCCCATCAGCCGGGAGA	0.572													0	0	0	0.016723	0	13	197										T	3977490	C	T	3977490	2	4	103	1	0	0	0	0	0	0	0	1	18252	813	29	1		1	ZZEF1	17	3977490	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	23199	3977490	77217720	103	31924										
NEURL4	84461	broad.mit.edu	37	chr17	7225069	7225069	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tggtcagccccagccgcaggGaacctgcccacttctcatct	9	17	3	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:7225069G>A	uc002gga.1	-	18	2916	c.2909C>T	c.(2908-2910)TCC>TTC	p.S970F	NEURL4_uc002gfy.1_5'Flank|GPS2_uc002gfz.1_5'Flank|NEURL4_uc002ggb.1_Missense_Mutation_p.S968F|NEURL4_uc002ggc.1_Missense_Mutation_p.S316F	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	970	NHR 5.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						CAGCCGCAGGGAACCTGCCCA	0.642													0	0	0	0.004482	0	9	48										A	7225069	G	A	7225069	3	1	103	1	0	0	0	0	1	0	0	0	10347	1174	41	1	1827	1	NEURL4	17	7225069	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	3247579	7225069	73970141	104	31925										
TP53	7157	broad.mit.edu	37	chr17	7578272	7578272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tccttccactcggataagatGctgaggaggggccagaccta	12	11	0	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:7578272G>A	uc002gim.2	-	6	771	c.577C>T	c.(577-579)CAT>TAT	p.H193Y	TP53_uc002gig.1_Missense_Mutation_p.H193Y|TP53_uc002gih.2_Missense_Mutation_p.H193Y|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61Y|TP53_uc010cng.1_Missense_Mutation_p.H61Y|TP53_uc002gii.1_Missense_Mutation_p.H61Y|TP53_uc010cnh.1_Missense_Mutation_p.H193Y|TP53_uc010cni.1_Missense_Mutation_p.H193Y|TP53_uc002gij.2_Missense_Mutation_p.H193Y|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100Y|TP53_uc002gio.2_Missense_Mutation_p.H61Y|TP53_uc010vug.1_Missense_Mutation_p.H154Y	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(29)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.P191fs*53(2)|p.H193H(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGATAAGATGCTGAGGAGGG	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.0333	0	18	41										A	7578272	G	A	7578272	3	1	103	1	0	0	0	0	1	0	0	0	16378	1319	46	2	717	2	TP53	17	7578272	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	353203	7578272	73616938	105	31926										
SMCR7	125170	broad.mit.edu	37	chr17	18167607	18167607	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtgcagcacgaacgcctggaGctcactgtggctgtgcttgt	14	11	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:18167607G>A	uc002gst.2	+	4	1105	c.894G>A	c.(892-894)GAG>GAA	p.E298E	SMCR7_uc002gsu.2_3'UTR|SMCR7_uc010vxq.1_Silent_p.E309E	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	298						integral to membrane	protein binding				0	all_neural(463;0.228)					AACGCCTGGAGCTCACTGTGG	0.682													0	0	0	0.02938	0	7	92										A	18167607	G	A	18167607	2	1	103	1	0	0	0	0	0	0	0	1	14790	962	34	2		2	SMCR7	17	18167607	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	10589335	18167607	63027603	106	31927										
SMCR7	125170	broad.mit.edu	37	chr17	18167950	18167950	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agctgctcatcggcagcctgGagcaggccagcctgccctgc	13	16	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:18167950G>C	uc002gst.2	+	4	1448	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q	SMCR7_uc002gsu.2_3'UTR|SMCR7_uc010vxq.1_Missense_Mutation_p.E424Q	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	413						integral to membrane	protein binding				0	all_neural(463;0.228)					CGGCAGCCTGGAGCAGGCCAG	0.622													0	0	0	0.021553	0	6	55										C	18167950	G	C	18167950	3	2	103	1	0	0	0	0	1	0	0	0	14790	1175	41	1	1284	1	SMCR7	17	18167950	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	343	18167950	63027260	107	31928										
TNFAIP1	7126	broad.mit.edu	37	chr17	26669328	26669328	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgtttgacaagctctccctgCgcttcaacggccgcgtgctc	10	15	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:26669328C>T	uc002hax.1	+	6	593	c.574C>T	c.(574-576)CGC>TGC	p.R192C	TNFAIP1_uc002hay.2_Missense_Mutation_p.R192C|TNFAIP1_uc010waf.1_Missense_Mutation_p.R88C	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	192					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GCTCTCCCTGCGCTTCAACGG	0.547													0	0	0	0.004482	0	9	41										T	26669328	C	T	26669328	3	4	103	1	0	0	0	0	1	0	0	0	16269	768	27	2	592	2	TNFAIP1	17	26669328	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	8501378	26669328	54525882	108	31929										
RNF135	84282	broad.mit.edu	37	chr17	29325811	29325811	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtgagaggttttctaccagcCaggtcttatgttcccaggcc	11	11	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:29325811C>G	uc002hfz.2	+	5	1037	c.901C>G	c.(901-903)CAG>GAG	p.Q301E	RNF135_uc002hga.2_3'UTR|RNF135_uc010csm.2_3'UTR|RNF135_uc002hgb.2_3'UTR	NM_032322	NP_115698	Q8IUD6	RN135_HUMAN	ring finger protein 135 isoform 1	301	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		skin(2)	2		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				TTCTACCAGCCAGGTCTTATG	0.557													0	0	0	0.02938	0	7	72										G	29325811	C	G	29325811	3	3	103	1	0	0	0	0	1	0	0	0	13440	595	21	4	988	4	RNF135	17	29325811	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	2656483	29325811	51869399	109	31930										
ERBB2	2064	broad.mit.edu	37	chr17	37881392	37881392	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtcccaaccatgtcaaaattAcagacttcgggctggctcgg	10	12	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:37881392A>G	uc002hso.2	+	21	2822	c.2584A>G	c.(2584-2586)ACA>GCA	p.T862A	ERBB2_uc002hsm.2_Missense_Mutation_p.T832A|ERBB2_uc010cwa.2_Missense_Mutation_p.T847A|ERBB2_uc002hsp.2_Missense_Mutation_p.T665A|ERBB2_uc010cwb.2_Missense_Mutation_p.T862A|ERBB2_uc010wek.1_Missense_Mutation_p.T586A	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	862	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.T862A(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGTCAAAATTACAGACTTCGG	0.582		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.028581	0	15	72										G	37881392	A	G	37881392	3	3	103	1	0	0	0	0	1	0	0	0	5206	391	14	5	2666	5	ERBB2	17	37881392	Missense_Mutation	SNP	A	TCGA-GC-A3OO-01A-11D-A22Z-08	8555581	37881392	43313818	110	31931										
PLEKHH3	79990	broad.mit.edu	37	chr17	40823447	40823447	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgcacggtacacagcagctcCtgccgttggctcaacgcgga	12	14	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:40823447C>T	uc002iau.2	-	8	1673	c.1206G>A	c.(1204-1206)CAG>CAA	p.Q402Q	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Silent_p.Q402Q	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	402					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		ACAGCAGCTCCTGCCGTTGGC	0.677													0	0	0	0.021553	0	5	41										T	40823447	C	T	40823447	2	4	103	1	0	0	0	0	0	0	0	1	12078	680	24	2		2	PLEKHH3	17	40823447	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	2942055	40823447	40371763	111	31932										
WFIKKN2	124857	broad.mit.edu	37	chr17	48917592	48917592	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atcaggctgcagccacctcaGagagcagccccaatggcacg	11	15	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:48917592G>A	uc002isv.3	+	2	1637	c.943G>A	c.(943-945)GAG>AAG	p.E315K	WFIKKN2_uc010dbu.2_Missense_Mutation_p.E222K	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	315						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			AGCCACCTCAGAGAGCAGCCC	0.657													0	0	0	0.006214	0	9	71										A	48917592	G	A	48917592	3	1	103	1	0	0	0	0	1	0	0	0	17356	943	33	1	949	1	WFIKKN2	17	48917592	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	8094145	48917592	32277618	112	31933										
TEX2	55852	broad.mit.edu	37	chr17	62248557	62248557	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agctcattcataaagtagggGagctagaggaaacaagcaaa	11	6	2	1	rs112066687		TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:62248557G>C	uc002jec.2	-	7	2747	c.2574C>G	c.(2572-2574)CTC>CTG	p.L858L	TEX2_uc002jed.2_Silent_p.L865L|TEX2_uc002jee.2_Silent_p.L858L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	858					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TAAAGTAGGGGAGCTAGAGGA	0.493													0	0	0	0.014758	0	5	38										C	62248557	G	C	62248557	2	2	103	1	0	0	0	0	0	0	0	1	15778	1161	41	1		1	TEX2	17	62248557	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	13330965	62248557	18946653	113	31934										
DDX5	1655	broad.mit.edu	37	chr17	62502215	62502215	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctcggtcccggccgcggtctCggtcactcgaataacccgac	11	17	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:62502215C>T	uc002jek.2	-	1	270	c.23G>A	c.(22-24)CGA>CAA	p.R8Q	CCDC45_uc002jem.2_5'Flank|CCDC45_uc002jen.2_5'Flank|CCDC45_uc010wqb.1_5'Flank|DDX5_uc010deh.2_5'Flank|DDX5_uc002jej.2_5'UTR|DDX5_uc010wqa.1_Missense_Mutation_p.R8Q|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	8					cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			GCCGCGGTCTCGGTCACTCGA	0.652			T	ETV4	prostate								0	0	0	0.014758	0	4	9										T	62502215	C	T	62502215	3	4	103	1	0	0	0	0	1	0	0	0	4367	884	31	1	1873	1	DDX5	17	62502215	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	253658	62502215	18692995	114	31935										
DNAH17	8632	broad.mit.edu	37	chr17	76547693	76547693	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gcaagttgtgcagaatttctCgcacctcttgaatgtactga	9	9	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr17:76547693C>G	uc002jvv.1	-	12	1527	c.1421G>C	c.(1420-1422)CGA>CCA	p.R474P						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGAATTTCTCGCACCTCTTG	0.338													0	0	0	0.00308	0	7	95										G	76547693	C	G	76547693	3	3	103	1	0	0	0	0	1	0	0	0	4601	884	31	1	11337	1	DNAH17	17	76547693	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	14045478	76547693	4647517	115	31936										
TUBB6	84617	broad.mit.edu	37	chr18	12308761	12308761	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gagactcggcgctgcagctgGagagaatcaacgtctactac	12	11	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr18:12308761G>A	uc002kqw.2	+	2	178	c.133G>A	c.(133-135)GAG>AAG	p.E45K	TUBB6_uc002kqv.2_5'UTR|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Missense_Mutation_p.E45K|TUBB6_uc002kqy.2_Missense_Mutation_p.E45K	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	45					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		GCTGCAGCTGGAGAGAATCAA	0.662													0	0	0	0.0333	0	16	76										A	12308761	G	A	12308761	3	1	103	1	0	0	0	0	1	0	0	0	16757	1175	41	1	139	1	TUBB6	18	12308761	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		12308761	65768487	116	31937										
FBXO15	201456	broad.mit.edu	37	chr18	71797676	71797676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ggcctctttggtcttaactgGaaggcctgtgtaagggttga	14	7	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr18:71797676G>A	uc002lle.2	-	4	658	c.322C>T	c.(322-324)CCA>TCA	p.P108S	FBXO15_uc002llf.2_Missense_Mutation_p.P184S	NM_152676	NP_689889	Q8NCQ5	FBX15_HUMAN	F-box protein 15 isoform 1	108										ovary(2)|pancreas(1)	3		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		GTCTTAACTGGAAGGCCTGTG	0.433													0	0	0	0.004482	0	8	74										A	71797676	G	A	71797676	3	1	103	1	0	0	0	0	1	0	0	0	5728	1174	41	1	1010	1	FBXO15	18	71797676	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	59488915	71797676	6279572	117	31938										
FSD1	79187	broad.mit.edu	37	chr19	4305978	4305978	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	atcatcaaaacactggctgtGaagaatgaagaaattcagag	9	6	3	5			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:4305978G>A	uc002lzy.2	+	2	204	c.51G>A	c.(49-51)GTG>GTA	p.V17V	FSD1_uc010xie.1_Intron|FSD1_uc010xif.1_Intron|FSD1_uc002lzz.2_Silent_p.V17V	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	17	Potential.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTGGCTGTGAAGAATGAAG	0.418													0	0	0	0.014323	0	19	58										A	4305978	G	A	4305978	2	1	103	1	0	0	0	0	0	0	0	1	6070	1277	45	1		1	FSD1	19	4305978	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		4305978	54823005	118	31939										
C19orf57	79173	broad.mit.edu	37	chr19	14000230	14000230	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ctctgtgttccagcacaacaGaggcttgcggggacacacgg	13	12	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:14000230G>A	uc002mxl.1	-	6	1498	c.1439C>T	c.(1438-1440)TCT>TTT	p.S480F	C19orf57_uc002mxk.1_Missense_Mutation_p.S362F|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	480					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CAGCACAACAGAGGCTTGCGG	0.607													0	0	0	0.010729	0	11	116										A	14000230	G	A	14000230	3	1	103	1	0	0	0	0	1	0	0	0	1939	942	33	1	486	1	C19orf57	19	14000230	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	9694252	14000230	45128753	119	31940										
UNC13A	23025	broad.mit.edu	37	chr19	17746845	17746845	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	caactcactggttgaggcagGgagtgtaggaattcttgtct	13	7	3	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:17746845G>A	uc002nhd.2	-	26	3467	c.3467C>T	c.(3466-3468)CCC>CTC	p.P1156L		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1068					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GTTGAGGCAGGGAGTGTAGGA	0.448													0	0	0	0.021553	0	6	20										A	17746845	G	A	17746845	3	1	103	1	0	0	0	0	1	0	0	0	16981	1232	43	2	1980	2	UNC13A	19	17746845	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	3746615	17746845	41382138	120	31941										
ZNF257	113835	broad.mit.edu	37	chr19	22271790	22271790	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	caaagcttttaactggtcctCagctcttactacccttactc	4	14	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:22271790C>G	uc010ecx.2	+	4	1407	c.1238C>G	c.(1237-1239)TCA>TGA	p.S413*	ZNF257_uc010ecy.2_Nonsense_Mutation_p.S381*	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	413	C2H2-type 9; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				AACTGGTCCTCAGCTCTTACT	0.398													0	0	0	0.006214	0	10	33										G	22271790	C	G	22271790	4	3	103	1	0	0	0	0	0	1	0	0	17797	838	29	1	1252	1	ZNF257	19	22271790	Nonsense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	4524945	22271790	36857193	121	31942										
ZNF235	9310	broad.mit.edu	37	chr19	44792882	44792882	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	accacaatcactattgctatGaactttatctcttttgtgca	4	10	2	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:44792882G>C	uc002oza.3	-	5	809	c.706C>G	c.(706-708)CAT>GAT	p.H236D	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF235_uc002ozb.3_Missense_Mutation_p.H232D|ZNF235_uc010xwx.1_Missense_Mutation_p.H150D	NM_004234	NP_004225	Q14590	ZN235_HUMAN	zinc finger protein 93 homolog	236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)	3		Prostate(69;0.0352)|all_neural(266;0.116)				CTATTGCTATGAACTTTATCT	0.358													0	0	0	0.00308	0	7	96										C	44792882	G	C	44792882	3	2	103	1	0	0	0	0	1	0	0	0	17785	1290	45	1	1514	1	ZNF235	19	44792882	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	22521092	44792882	14336101	122	31943										
PIH1D1	55011	broad.mit.edu	37	chr19	49954759	49954759	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cacctgcagcagcagctcctCaaatcgcgccgaatcagcac	8	17	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:49954759C>T	uc002pns.2	-	1	357	c.73G>A	c.(73-75)GAG>AAG	p.E25K	PIH1D1_uc010yap.1_Missense_Mutation_p.E25K|PIH1D1_uc010yaq.1_Missense_Mutation_p.E25K|ALDH16A1_uc002pnt.2_5'Flank|ALDH16A1_uc010yar.1_5'Flank|ALDH16A1_uc010yas.1_5'Flank|ALDH16A1_uc010yat.1_5'Flank	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17	25					box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		AGCAGCTCCTCAAATCGCGCC	0.602													0	0	0	0.02938	0	6	90										T	49954759	C	T	49954759	3	4	103	1	0	0	0	0	1	0	0	0	11906	835	29	1	835	1	PIH1D1	19	49954759	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	5161877	49954759	9174224	123	31944										
ZNF615	284370	broad.mit.edu	37	chr19	52497183	52497183	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gtgataagactgttcttcaaGgtgaagcctttcccacattt	8	9	2	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr19:52497183G>C	uc002pye.1	-	6	1438	c.1146C>G	c.(1144-1146)ACC>ACG	p.T382T	ZNF615_uc002pyf.1_Silent_p.T393T|ZNF615_uc002pyg.1_Silent_p.T274T|ZNF615_uc002pyh.1_Silent_p.T393T|ZNF615_uc010epi.1_Silent_p.T389T|ZNF615_uc010ydg.1_Silent_p.T387T	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	382	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGTTCTTCAAGGTGAAGCCTT	0.398													0	0	0	0.006214	0	10	93										C	52497183	G	C	52497183	2	2	103	1	0	0	0	0	0	0	0	1	18037	987	35	4		4	ZNF615	19	52497183	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	2542424	52497183	6631800	124	31945										
NINL	22981	broad.mit.edu	37	chr20	25472060	25472060	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	gccccacgtcccactccagcGcggccctctgcctgtgggcc	11	21	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr20:25472060G>A	uc002wux.1	-	11	1486	c.1412C>T	c.(1411-1413)GCG>GTG	p.A471V	NINL_uc010gdn.1_Missense_Mutation_p.A471V|NINL_uc010gdo.1_Missense_Mutation_p.A254V|NINL_uc010ztf.1_Missense_Mutation_p.A487V	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	471					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CCACTCCAGCGCGGCCCTCTG	0.692													0	0	0	0.010729	0	10	76										A	25472060	G	A	25472060	3	1	103	1	0	0	0	0	1	0	0	0	10420	1087	38	2	2792	2	NINL	20	25472060	Missense_Mutation	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		25472060	37553460	125	31946										
ZNF334	55713	broad.mit.edu	37	chr20	45140739	45140739	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	acctgaaattttttcattttCatgttctcttgagaaagggc	7	7	3	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr20:45140739C>T	uc002xsc.2	-	2	187	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ZNF334_uc002xsd.2_5'UTR|ZNF334_uc010ghl.2_5'UTR	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				TTTTCATTTTCATGTTCTCTT	0.403													0	0	0	0.004482	0	8	71										T	45140739	C	T	45140739	3	4	103	1	0	0	0	0	1	0	0	0	17848	826	29	1	2055	1	ZNF334	20	45140739	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	19668679	45140739	17884781	126	31947										
LSS	4047	broad.mit.edu	37	chr21	47614422	47614422	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	caccgaacggccatcagcccCatcatggcccagcatgtgtt	9	16	2	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr21:47614422C>T	uc002zij.2	-	20	2050	c.1971G>A	c.(1969-1971)ATG>ATA	p.M657I	LSS_uc011afv.1_Missense_Mutation_p.M646I|LSS_uc002zil.2_Missense_Mutation_p.M657I|LSS_uc002zik.2_Missense_Mutation_p.M577I	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	657					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					CCATCAGCCCCATCATGGCCC	0.632													0	0	0	0.009096	0	4	34										T	47614422	C	T	47614422	3	4	103	1	0	0	0	0	1	0	0	0	9065	594	21	2	239	2	LSS	21	47614422	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08		47614422	515473	127	31948										
ZNF280A	129025	broad.mit.edu	37	chr22	22869055	22869055	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	agaactttcacgcagctgagGcatttaaaggtggtgtgagt	13	6	1	3			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr22:22869055G>A	uc002zwe.2	-	2	1153	c.900C>T	c.(898-900)TGC>TGT	p.C300C	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CGCAGCTGAGGCATTTAAAGG	0.413													0	0	0	0.013726	0	35	179										A	22869055	G	A	22869055	2	1	103	1	0	0	0	0	0	0	0	1	17811	1195	42	2		2	ZNF280A	22	22869055	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08		22869055	28435511	128	31949										
NIPSNAP1	8508	broad.mit.edu	37	chr22	29966488	29966488	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ttgtgaacaaagagggagcgGaaccagctgccttcattgtc	12	9	1	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr22:29966488G>A	uc003afx.3	-	2	205	c.132C>T	c.(130-132)TTC>TTT	p.F44F	NIPSNAP1_uc011akp.1_Silent_p.F24F	NM_003634	NP_003625	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1	44								p.?(1)		skin(1)	1						AGAGGGAGCGGAACCAGCTGC	0.552													0	0	0	0.014758	0	4	32										A	29966488	G	A	29966488	2	1	103	1	0	0	0	0	0	0	0	1	10429	1165	41	1		1	NIPSNAP1	22	29966488	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	7097433	29966488	21338078	129	31950										
SLC5A1	6523	broad.mit.edu	37	chr22	32506039	32506039	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	cctatgacctattttgtgggCtagagcagcacggtgcaccc	11	12	0	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr22:32506039C>T	uc003amc.2	+	15	2066	c.1834C>T	c.(1834-1836)CTA>TTA	p.L612L	SLC5A1_uc011alz.1_Silent_p.L485L	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	612	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						ATTTTGTGGGCTAGAGCAGCA	0.468													0	0	0	0.028581	0	15	74										T	32506039	C	T	32506039	2	4	103	1	0	0	0	0	0	0	0	1	14661	796	28	2		2	SLC5A1	22	32506039	Silent	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	2539551	32506039	18798527	130	31951										
LDOC1L	84247	broad.mit.edu	37	chr22	44892894	44892894	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tgggcgcgccgcgcatgccgGagcggagacttgtaggttct	17	11	1	1			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chr22:44892894G>C	uc003beu.1	-	2	880	c.543C>G	c.(541-543)CTC>CTG	p.L181L		NM_032287	NP_115663	Q6ICC9	LDOCL_HUMAN	leucine zipper, down-regulated in cancer 1-like	181										ovary(1)	1		Ovarian(80;0.024)|all_neural(38;0.0416)		LUAD - Lung adenocarcinoma(64;0.0161)		GCGCATGCCGGAGCGGAGACT	0.622													0	0	0	0.006122	0	19	29										C	44892894	G	C	44892894	2	2	103	1	0	0	0	0	0	0	0	1	8710	1161	41	1		1	LDOC1L	22	44892894	Silent	SNP	G	TCGA-GC-A3OO-01A-11D-A22Z-08	12386855	44892894	6411672	131	31952										
ZBED1	9189	broad.mit.edu	37	chrX	2407457	2407457	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	tggagtcggtctccttgatgTtgagcgtggtgttcaggagc	16	7	2	2			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chrX:2407457T>C	uc004cqg.2	-	2	1505	c.1304A>G	c.(1303-1305)AAC>AGC	p.N435S	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.N435S	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	435						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTCCTTGATGTTGAGCGTGGT	0.587													0	0	0	0.016723	0	13	88										C	2407457	T	C	2407457	3	2	103	1	0	0	0	0	1	0	0	0	17514	1725	60	5	784	5	ZBED1	23	2407457	Missense_Mutation	SNP	T	TCGA-GC-A3OO-01A-11D-A22Z-08		2407457	152863103	132	31953										
MAGIX	79917	broad.mit.edu	37	chrX	49022469	49022469	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.503759398496241	67	7.37713625715464e-23	3.65173210161663	4.08775981524249	3.49317656938904	7.42995802452519e-06	6.4392969545885e-05	49	ggccggaggtaacggggtctCgcagcagcagcacttcccta	14	13	1	0			TCGA-GC-A3OO-01A-11D-A22Z-08	TCGA-GC-A3OO-10C-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8ca635e2-a609-46a9-ab15-12ddb5233a68	5c5ecfa1-e4bd-492c-bfff-5e4667637469	g.chrX:49022469C>G	uc010nin.1	+	6	783	c.736C>G	c.(736-738)CGC>GGC	p.R246G	MAGIX_uc010nio.1_Missense_Mutation_p.R170G|MAGIX_uc004dmt.2_Missense_Mutation_p.R165G|MAGIX_uc004dmu.2_Missense_Mutation_p.R187G|MAGIX_uc004dmw.2_Missense_Mutation_p.R174G	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	246											0						AACGGGGTCTCGCAGCAGCAG	0.637													0	0	0	0.014758	0	5	34										G	49022469	C	G	49022469	3	3	103	1	0	0	0	0	1	0	0	0	9193	884	31	1	798	1	MAGIX	23	49022469	Missense_Mutation	SNP	C	TCGA-GC-A3OO-01A-11D-A22Z-08	46615012	49022469	106248091	133	31954										
H6PD	9563	broad.mit.edu	37	chr1	9324107	9324107	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	actttgagttcagtagcggcCggttgttcttttcccagcag	11	10	2	1	rs35863691	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:9324107C>T	uc001apt.2	+	5	1828	c.1555C>T	c.(1555-1557)CGG>TGG	p.R519W		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	519	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CAGTAGCGGCCGGTTGTTCTT	0.637													0	0	0	0.00278	0	23	233										T	9324107	C	T	9324107	3	4	104	1	0	0	0	0	1	0	0	0	6936	643	23	2	1569	2	H6PD	1	9324107	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		9324107	239926514	1	31955										
PLA2G2A	5320	broad.mit.edu	37	chr1	20302318	20302318	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cacactcacacagttgacttCtgcaggagtcctgttttgct	8	12	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:20302318C>T	uc001bcu.2	-	5	529	c.311G>A	c.(310-312)AGA>AAA	p.R104K	PLA2G2A_uc001bcv.2_Missense_Mutation_p.R104K|PLA2G2A_uc010oda.1_Missense_Mutation_p.R104K|PLA2G2A_uc010odb.1_Missense_Mutation_p.R104K	NM_001161729	NP_001155201	P14555	PA2GA_HUMAN	phospholipase A2, group IIA precursor	104					defense response to Gram-positive bacterium|lipid catabolic process|low-density lipoprotein particle remodeling|phosphatidic acid metabolic process|positive regulation of inflammatory response|positive regulation of macrophage derived foam cell differentiation	endoplasmic reticulum|extracellular space|membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|phospholipid binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000138)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.00032)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTTGACTTCTGCAGGAGTC	0.398													0	0	0	0.008291	0	10	39										T	20302318	C	T	20302318	3	4	104	1	0	0	0	0	1	0	0	0	11995	913	32	1	127	1	PLA2G2A	1	20302318	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	10978211	20302318	228948303	2	31956										
KIF2C	11004	broad.mit.edu	37	chr1	45226006	45226006	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tcccgctcccacgcgtgcttCcaaattattcttcgagctaa	6	15	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:45226006C>T	uc001cmg.3	+	15	1537	c.1422C>T	c.(1420-1422)TTC>TTT	p.F474F	KIF2C_uc010olb.1_Silent_p.F433F|KIF2C_uc010olc.1_Silent_p.F361F|KIF2C_uc001cmh.3_Silent_p.F420F	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	474	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACGCGTGCTTCCAAATTATTC	0.527													0	0	0	0.003755	0	33	23										T	45226006	C	T	45226006	2	4	104	1	0	0	0	0	0	0	0	1	8299	854	30	1		1	KIF2C	1	45226006	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	24923688	45226006	204024615	3	31957										
ZCCHC11	23318	broad.mit.edu	37	chr1	52941116	52941116	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtctgaggacaggcaaaataCcgataagctgccctaaatct	9	10	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:52941116C>T	uc001ctx.2	-	13	2349	c.2115G>A	c.(2113-2115)CGG>CGA	p.R705R	ZCCHC11_uc001cty.2_Silent_p.R705R|ZCCHC11_uc001ctz.2_Silent_p.R705R|ZCCHC11_uc009vze.1_Silent_p.R705R|ZCCHC11_uc009vzf.1_Silent_p.R464R|ZCCHC11_uc001cub.2_Silent_p.R705R	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	705					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AGGCAAAATACCGATAAGCTG	0.418													0	0	0	0.007413	0	19	55										T	52941116	C	T	52941116	2	4	104	1	0	0	0	0	0	0	0	1	17577	494	18	2		2	ZCCHC11	1	52941116	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	7715110	52941116	196309505	4	31958										
GBP4	115361	broad.mit.edu	37	chr1	89661003	89661003	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttctacatcgcccaggccctCggtgtccagaaggaccaggg	12	14	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:89661003C>T	uc001dnb.2	-	3	456	c.340G>A	c.(340-342)GAG>AAG	p.E114K		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	114	GTP (By similarity).					cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CCCAGGCCCTCGGTGTCCAGA	0.522													0	0	0	0.01441	0	55	111										T	89661003	C	T	89661003	3	4	104	1	0	0	0	0	1	0	0	0	6276	893	31	1	1618	1	GBP4	1	89661003	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	36719887	89661003	159589618	5	31959										
SLC44A3	126969	broad.mit.edu	37	chr1	95360474	95360474	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agaactccaggccattgtgaGatagatacccatttaggtat	9	8	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:95360474G>C	uc001dqv.3	+	15	2065	c.1958G>C	c.(1957-1959)AGA>ACA	p.R653T	SLC44A3_uc001dqx.3_Missense_Mutation_p.R652T|SLC44A3_uc010otq.1_Missense_Mutation_p.R585T|SLC44A3_uc010otr.1_Missense_Mutation_p.R617T|SLC44A3_uc001dqw.3_Missense_Mutation_p.R605T|SLC44A3_uc010ots.1_Missense_Mutation_p.R573T|SLC44A3_uc009wds.2_Missense_Mutation_p.R556T|SLC44A3_uc010ott.1_Missense_Mutation_p.R572T	NM_001114106	NP_001107578	Q8N4M1	CTL3_HUMAN	solute carrier family 44, member 3 isoform 1	653						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)	1		all_lung(203;0.000712)|Lung NSC(277;0.00316)		all cancers(265;0.039)|Epithelial(280;0.124)	Choline(DB00122)	GCCATTGTGAGATAGATACCC	0.393													0	0	0	0.00632	0	23	40										C	95360474	G	C	95360474	3	2	104	1	0	0	0	0	1	0	0	0	14637	942	33	1	2016	1	SLC44A3	1	95360474	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	5699471	95360474	153890147	6	31960										
OLFM3	118427	broad.mit.edu	37	chr1	102271652	102271652	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tctgttgtttttctcagatgCtaaagggtctgtcatccaag	9	8	4	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:102271652C>G	uc001duf.2	-	5	810	c.739G>C	c.(739-741)GCA>CCA	p.A247P	OLFM3_uc001dug.2_Missense_Mutation_p.A227P|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.A152P|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	247	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TTCTCAGATGCTAAAGGGTCT	0.398													0	0	0	0.007413	0	15	135										G	102271652	C	G	102271652	3	3	104	1	0	0	0	0	1	0	0	0	10854	797	28	4	705	4	OLFM3	1	102271652	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	6911178	102271652	146978969	7	31961										
WDR47	22911	broad.mit.edu	37	chr1	109538452	109538452	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	atttaattcaccaagcttttGaatggacctataaaattaaa	4	6	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:109538452G>C	uc001dwj.2	-	8	1817	c.1441C>G	c.(1441-1443)CAA>GAA	p.Q481E	WDR47_uc001dwl.2_Missense_Mutation_p.Q489E|WDR47_uc001dwi.2_Missense_Mutation_p.Q482E|WDR47_uc001dwk.2_Missense_Mutation_p.Q453E|WDR47_uc010ovf.1_Missense_Mutation_p.Q408E	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	481										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		CCAAGCTTTTGAATGGACCTA	0.313													0	0	0	0.00278	0	24	78										C	109538452	G	C	109538452	3	2	104	1	0	0	0	0	1	0	0	0	17297	1299	45	1	1350	1	WDR47	1	109538452	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	7266800	109538452	139712169	8	31962										
KCND3	3752	broad.mit.edu	37	chr1	112525046	112525046	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tagcgcgggtagtgcagcttCcccgtgcggtagaagttgag	16	9	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:112525046C>T	uc001ebu.1	-	2	783	c.303G>A	c.(301-303)GGG>GGA	p.G101G	KCND3_uc001ebv.1_Silent_p.G101G	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	101	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		AGTGCAGCTTCCCCGTGCGGT	0.607													0	0	0	0.003755	0	30	139										T	112525046	C	T	112525046	2	4	104	1	0	0	0	0	0	0	0	1	8020	842	30	1		1	KCND3	1	112525046	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	2986594	112525046	136725575	9	31963										
ATP1A1	476	broad.mit.edu	37	chr1	116932065	116932065	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tccccttctttttaaggcacCgcacgtggtattgttgtcta	8	11	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:116932065C>T	uc001ege.2	+	8	1098	c.759C>T	c.(757-759)ACC>ACT	p.T253T	ATP1A1_uc010owv.1_Silent_p.T222T|ATP1A1_uc010oww.1_Silent_p.T253T|ATP1A1_uc010owx.1_Silent_p.T222T	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	253	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTTAAGGCACCGCACGTGGTA	0.473													0	0	0	0.01441	0	46	193										T	116932065	C	T	116932065	2	4	104	1	0	0	0	0	0	0	0	1	1128	639	23	2		2	ATP1A1	1	116932065	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4407019	116932065	132318556	10	31964										
ATP1A1	476	broad.mit.edu	37	chr1	116932235	116932235	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgtgtctttcttcatcctttCtctcatccttgagtacacct	4	13	5	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:116932235C>G	uc001ege.2	+	8	1268	c.929C>G	c.(928-930)TCT>TGT	p.S310C	ATP1A1_uc010owv.1_Missense_Mutation_p.S279C|ATP1A1_uc010oww.1_Missense_Mutation_p.S310C|ATP1A1_uc010owx.1_Missense_Mutation_p.S279C	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	310	Extracellular (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TTCATCCTTTCTCTCATCCTT	0.507													0	0	0	0.007413	0	16	56										G	116932235	C	G	116932235	3	3	104	1	0	0	0	0	1	0	0	0	1128	913	32	1	975	1	ATP1A1	1	116932235	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	170	116932235	132318386	11	31965										
TARS2	80222	broad.mit.edu	37	chr1	150459941	150459941	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aggaacatggccctgtatcaGaggtggcggtgtctccggct	15	10	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150459941G>C	uc001euq.2	+	1	22	c.15G>C	c.(13-15)CAG>CAC	p.Q5H	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.Q5H|TARS2_uc009wlt.2_5'UTR|TARS2_uc009wls.2_Missense_Mutation_p.Q5H	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	5					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCCTGTATCAGAGGTGGCGGT	0.552													0	0	0	0.004656	0	21	225										C	150459941	G	C	150459941	3	2	104	1	0	0	0	0	1	0	0	0	15557	933	33	1	17	1	TARS2	1	150459941	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	33527706	150459941	98790680	12	31966										
TARS2	80222	broad.mit.edu	37	chr1	150460385	150460385	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cagagcggcttggcctttttGaggagctgtgggctgctcag	16	9	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150460385G>A	uc001euq.2	+	2	125	c.118G>A	c.(118-120)GAG>AAG	p.E40K	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.E40K|TARS2_uc009wlt.2_5'UTR|TARS2_uc009wls.2_Missense_Mutation_p.E40K	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	40					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TGGCCTTTTTGAGGAGCTGTG	0.507													0	0	0	0.007835	0	38	263										A	150460385	G	A	150460385	3	1	104	1	0	0	0	0	1	0	0	0	15557	1291	45	1	124	1	TARS2	1	150460385	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	444	150460385	98790236	13	31967										
TARS2	80222	broad.mit.edu	37	chr1	150463886	150463886	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccaggacaatccggggctcaGagctgcctgttttggagcgg	15	11	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150463886G>C	uc001euq.2	+	5	536	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.E177Q|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Missense_Mutation_p.E177Q	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	177					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCGGGGCTCAGAGCTGCCTGT	0.552													0	0	0	0.004289	0	34	254										C	150463886	G	C	150463886	3	2	104	1	0	0	0	0	1	0	0	0	15557	943	33	1	547	1	TARS2	1	150463886	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	3501	150463886	98786735	14	31968										
ADAMTSL4	54507	broad.mit.edu	37	chr1	150532263	150532263	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgctcctgccaagggggaacGcagacacgggaggtccagtg	16	12	0	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:150532263G>A	uc001eux.2	+	18	3206	c.2970G>A	c.(2968-2970)ACG>ACA	p.T990T	ADAMTSL4_uc009wlw.2_Silent_p.T1013T|ADAMTSL4_uc010pcg.1_Silent_p.T951T|ADAMTSL4_uc009wlx.2_Silent_p.T153T	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	990	TSP type-1 6.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AAGGGGGAACGCAGACACGGG	0.637											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	28	533										A	150532263	G	A	150532263	2	1	104	1	0	0	0	0	0	0	0	1	277	1074	38	2		2	ADAMTSL4	1	150532263	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	68377	150532263	98718358	15	31969										
PIP5K1A	8394	broad.mit.edu	37	chr1	151205150	151205150	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aacataaagaggcggaatttCtgcagaagctgcttccagga	11	8	1	2	rs148159537	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:151205150C>G	uc001exj.2	+	7	1062	c.610C>G	c.(610-612)CTG>GTG	p.L204V	PIP5K1A_uc001exi.2_Missense_Mutation_p.L191V|PIP5K1A_uc010pcu.1_Missense_Mutation_p.L192V|PIP5K1A_uc001exk.2_Missense_Mutation_p.L191V|PIP5K1A_uc010pcv.1_5'Flank	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	204	PIPK.				phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGCGGAATTTCTGCAGAAGCT	0.498													0	0	0	0.003954	0	19	152										G	151205150	C	G	151205150	3	3	104	1	0	0	0	0	1	0	0	0	11939	912	32	1	636	1	PIP5K1A	1	151205150	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	672887	151205150	98045471	16	31970										
FLG	2312	broad.mit.edu	37	chr1	152280743	152280743	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcttcatgatgatgcgaccCtgagtgcctagagccatctc	10	12	2	4	rs71625185		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:152280743C>G	uc001ezu.1	-	3	6655	c.6619G>C	c.(6619-6621)GGG>CGG	p.G2207R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2207	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGATGCGACCCTGAGTGCCTA	0.572									Ichthyosis				0	0	0	0.009535	0	29	572										G	152280743	C	G	152280743	3	3	104	1	0	0	0	0	1	0	0	0	5922	681	24	4	5570	4	FLG	1	152280743	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	1075593	152280743	96969878	17	31971										
FLG	2312	broad.mit.edu	37	chr1	152286605	152286605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tctttcatatattttgttttCttctaatagactatcagtgg	5	6	5	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:152286605C>G	uc001ezu.1	-	3	793	c.757G>C	c.(757-759)GAA>CAA	p.E253Q	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	253					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTTTGTTTTCTTCTAATAGA	0.378									Ichthyosis				0	0	0	0.01441	0	68	381										G	152286605	C	G	152286605	3	3	104	1	0	0	0	0	1	0	0	0	5922	922	32	1	11432	1	FLG	1	152286605	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	5862	152286605	96964016	18	31972										
FLG	2312	broad.mit.edu	37	chr1	152287125	152287125	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	taatatgcttgagccaacttGaataccatcagaagaaactc	6	9	1	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:152287125G>A	uc001ezu.1	-	3	273	c.237C>T	c.(235-237)TTC>TTT	p.F79F	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	79	EF-hand 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAACTTGAATACCATCA	0.378									Ichthyosis				0	0	0	0.004656	0	26	174										A	152287125	G	A	152287125	2	1	104	1	0	0	0	0	0	0	0	1	5922	1281	45	1		1	FLG	1	152287125	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	520	152287125	96963496	19	31973										
FCRL2	79368	broad.mit.edu	37	chr1	157738266	157738266	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggccgttgtcagctctacagTaatatttgccggcatcactc	9	12	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:157738266T>A	uc001fre.2	-	5	880	c.821A>T	c.(820-822)TAC>TTC	p.Y274F	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.Y274F|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	274	Ig-like C2-type 3.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCTCTACAGTAATATTTGCC	0.498													0	0	0	0.00245	0	14	169										A	157738266	T	A	157738266	3	1	104	1	0	0	0	0	1	0	0	0	5795	1638	57	5	737	5	FCRL2	1	157738266	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	5451141	157738266	91512355	20	31974										
XPR1	9213	broad.mit.edu	37	chr1	180775611	180775611	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	taataatttgtctttctaggCtgtagtgaccaatgaacttg	8	6	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:180775611C>T	uc001goi.2	+	6	791	c.599C>T	c.(598-600)GCT>GTT	p.A200V	XPR1_uc009wxm.2_Missense_Mutation_p.A200V|XPR1_uc009wxn.2_Missense_Mutation_p.A200V	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	200	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						TCTTTCTAGGCTGTAGTGACC	0.368													0	0	0	0.005443	0	22	69										T	180775611	C	T	180775611	3	4	104	1	0	0	0	0	1	0	0	0	17448	811	28	2	621	2	XPR1	1	180775611	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	23037345	180775611	68475010	21	31975										
CFHR2	3080	broad.mit.edu	37	chr1	196920122	196920122	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acaacatttcatgtgtagaaCggggctggtccactcctccc	9	13	1	1	rs111586074		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:196920122C>T	uc001gtq.1	+	3	471	c.394C>T	c.(394-396)CGG>TGG	p.R132W	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	132	Sushi 2.					extracellular region				skin(2)|ovary(1)	3						ATGTGTAGAACGGGGCTGGTC	0.373													0	0	0	0.01441	0	57	39										T	196920122	C	T	196920122	3	4	104	1	0	0	0	0	1	0	0	0	3285	527	19	2	404	2	CFHR2	1	196920122	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	16144511	196920122	52330499	22	31976										
RPS6KC1	26750	broad.mit.edu	37	chr1	213414318	213414318	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctctccaaagtggccagattCtggttcaagttcagaagaag	10	9	4	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:213414318C>G	uc010ptr.1	+	11	1658	c.1499C>G	c.(1498-1500)TCT>TGT	p.S500C	RPS6KC1_uc001hkd.2_Missense_Mutation_p.S488C|RPS6KC1_uc010pts.1_Missense_Mutation_p.S288C|RPS6KC1_uc010ptt.1_Missense_Mutation_p.S288C|RPS6KC1_uc010ptu.1_Missense_Mutation_p.S319C|RPS6KC1_uc010ptv.1_Missense_Mutation_p.S35C|RPS6KC1_uc001hke.2_Missense_Mutation_p.S319C	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	500					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TGGCCAGATTCTGGTTCAAGT	0.413													0	0	0	0.00278	0	19	34										G	213414318	C	G	213414318	3	3	104	1	0	0	0	0	1	0	0	0	13658	913	32	1	1541	1	RPS6KC1	1	213414318	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	16494196	213414318	35836303	23	31977										
CENPF	1063	broad.mit.edu	37	chr1	214820493	214820493	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggatgaagaaatcagtagacTgaaaaatcaaattcaagacc	8	6	3	5			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:214820493T>C	uc001hkm.2	+	13	7754	c.7580T>C	c.(7579-7581)CTG>CCG	p.L2527P		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2623	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ATCAGTAGACTGAAAAATCAA	0.388													0	0	0	0.000602	0	4	56										C	214820493	T	C	214820493	3	2	104	1	0	0	0	0	1	0	0	0	3231	1580	55	5	7626	5	CENPF	1	214820493	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	1406175	214820493	34430128	24	31978										
EXOC8	149371	broad.mit.edu	37	chr1	231472540	231472540	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctcaggaacagctggttcttCttcttcgtcatcctcaaatg	7	12	6	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:231472540C>T	uc001huq.2	-	1	1039	c.952G>A	c.(952-954)GAA>AAA	p.E318K		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	318	Poly-Glu.				exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GCTGGTTCTTCTTCTTCGTCA	0.557													0	0	0	0.01441	0	49	68										T	231472540	C	T	231472540	3	4	104	1	0	0	0	0	1	0	0	0	5311	922	32	1	1229	1	EXOC8	1	231472540	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	16652047	231472540	17778081	25	31979										
LYST	1130	broad.mit.edu	37	chr1	235952011	235952011	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	taatcaataccgaaagataaGagtggcattgtggggatcag	12	5	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:235952011G>C	uc001hxj.2	-	13	4853	c.4678C>G	c.(4678-4680)CTT>GTT	p.L1560V	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1560					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CGAAAGATAAGAGTGGCATTG	0.358									Chediak-Higashi_syndrome				0	0	0	0.00499	0	11	46										C	235952011	G	C	235952011	3	2	104	1	0	0	0	0	1	0	0	0	9128	942	33	1	6891	1	LYST	1	235952011	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	4479471	235952011	13298610	26	31980										
FMN2	56776	broad.mit.edu	37	chr1	240286571	240286571	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cccggatcattgccatgggtCttctccttccttttagtgat	8	12	3	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:240286571C>T	uc010pyd.1	+	2	1933	c.1708C>T	c.(1708-1710)CTT>TTT	p.L570F	FMN2_uc010pye.1_Missense_Mutation_p.L570F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	570					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGCCATGGGTCTTCTCCTTCC	0.502													0	0	0	0.012319	0	19	81										T	240286571	C	T	240286571	3	4	104	1	0	0	0	0	1	0	0	0	5950	913	32	1	1714	1	FMN2	1	240286571	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4334560	240286571	8964050	27	31981										
OR2T4	127074	broad.mit.edu	37	chr1	248525601	248525601	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtgctgtgtcctcatgctccTcatccctgtggtgatcattt	9	12	3	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr1:248525601T>C	uc001ieh.1	+	1	719	c.719T>C	c.(718-720)CTC>CCC	p.L240P		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	240	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCATGCTCCTCATCCCTGTG	0.483													0	0	0	0.006122	0	14	203										C	248525601	T	C	248525601	3	2	104	1	0	0	0	0	1	0	0	0	11027	1551	54	5	721	5	OR2T4	1	248525601	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	8239030	248525601	725020	28	31982										
APOB	338	broad.mit.edu	37	chr2	21258577	21258577	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gatcagagttgacaaggggcGggtctatgaaagagattgga	16	4	2	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:21258577G>A	uc002red.2	-	7	825	c.697C>T	c.(697-699)CGC>TGC	p.R233C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	233	Vitellogenin.|Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GACAAGGGGCGGGTCTATGAA	0.498													0	0	0	0.00632	0	23	29										A	21258577	G	A	21258577	3	1	104	1	0	0	0	0	1	0	0	0	785	1116	39	2	13086	2	APOB	2	21258577	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		21258577	221940796	29	31983										
DHX57	90957	broad.mit.edu	37	chr2	39085813	39085813	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cataccctacctgtttcattCggaactgcttgcagatttta	6	11	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:39085813C>G	uc002rrf.2	-	6	1676	c.1577G>C	c.(1576-1578)CGA>CCA	p.R526P	DHX57_uc002rre.2_5'UTR|DHX57_uc002rrg.2_Missense_Mutation_p.R526P	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	526							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				CTGTTTCATTCGGAACTGCTT	0.408													0	0	0	0.01441	0	63	295										G	39085813	C	G	39085813	3	3	104	1	0	0	0	0	1	0	0	0	4513	884	31	1	2659	1	DHX57	2	39085813	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	17827236	39085813	204113560	30	31984										
FOXN2	3344	broad.mit.edu	37	chr2	48602364	48602364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cagacgttgattatgaagatGatcctcttggagacagtggc	12	7	1	6			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:48602364G>A	uc002rwh.1	+	7	1393	c.1078G>A	c.(1078-1080)GAT>AAT	p.D360N		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	360					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TTATGAAGATGATCCTCTTGG	0.413													0	0	0	0.014323	0	21	74										A	48602364	G	A	48602364	3	1	104	1	0	0	0	0	1	0	0	0	6020	1290	45	1	1096	1	FOXN2	2	48602364	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	9516551	48602364	194597009	31	31985										
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48874053	48874053	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agtccctctccacaagccctCatggggctctccaccagcac	7	19	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:48874053C>G	uc010yol.1	+	5	2868	c.2821C>G	c.(2821-2823)CAT>GAT	p.H941D	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.H988D|GTF2A1L_uc002rws.1_Missense_Mutation_p.H284D|GTF2A1L_uc010yom.1_Missense_Mutation_p.H250D|GTF2A1L_uc002rwt.2_Missense_Mutation_p.H284D	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	941					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CACAAGCCCTCATGGGGCTCT	0.438													0	0	0	0.00499	0	14	55										G	48874053	C	G	48874053	3	3	104	1	0	0	0	0	1	0	0	0	15316	826	29	1	2988	1	STON1-GTF2A1L	2	48874053	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	271689	48874053	194325320	32	31986										
LHCGR	3973	broad.mit.edu	37	chr2	48925887	48925887	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgtggcaattagcctctgaaTggactctaggccatagctcg	11	11	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:48925887T>C	uc002rwu.3	-	9	803	c.733A>G	c.(733-735)ATT>GTT	p.I245V	GTF2A1L_uc002rwt.2_Intron|LHCGR_uc002rwv.2_RNA	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	245	Extracellular (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AGCCTCTGAATGGACTCTAGG	0.413									Familial_Male-Limited_Precocious_Puberty				0	0	0	0.003271	0	29	45										C	48925887	T	C	48925887	3	2	104	1	0	0	0	0	1	0	0	0	8762	1464	51	5	1378	5	LHCGR	2	48925887	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	51834	48925887	194273486	33	31987										
ELMOD3	84173	broad.mit.edu	37	chr2	85604471	85604471	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acggtctctgttacaggagcGaatccagccacagacctgag	11	12	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:85604471G>A	uc002spf.3	+	12	1277	c.612G>A	c.(610-612)GCG>GCA	p.A204A	ELMOD3_uc010fgg.2_RNA|ELMOD3_uc002spg.3_Silent_p.A204A|ELMOD3_uc002sph.3_Silent_p.A204A|ELMOD3_uc010ysn.1_Silent_p.A204A|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_RNA	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	204	ELMO.				phagocytosis	cytoskeleton				ovary(2)	2						TTACAGGAGCGAATCCAGCCA	0.587													0	0	0	0.00245	0	12	61										A	85604471	G	A	85604471	2	1	104	1	0	0	0	0	0	0	0	1	5070	1045	37	1		1	ELMOD3	2	85604471	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	36678584	85604471	157594902	34	31988										
WDR33	55339	broad.mit.edu	37	chr2	128471200	128471200	+	Frame_Shift_Del	DEL	G	G	-													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acgtgggtcctcgggatcccGggggaaacgttcatctccgg							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:128471200delG	uc002tpg.1	-	18	3448	c.3265delC	c.(3265-3267)CGGfs	p.R1089fs		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1089					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TCGGGATCCCGGGGGAAACGT	0.617																		7	607	---	---								-	128471200	G	-	128471200	7	5	104	1	0	1	0	1	0	0	0	0	17284	1115	39	0	765	0	WDR33	2	128471200	Frame_Shift_Del	DEL	G	TCGA-GC-A3RB-01A-12D-A21Z-08	42866729	128471200	114728173	35	31989										
UGGT1	56886	broad.mit.edu	37	chr2	128945037	128945037	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tcacagtgtaataatccgatGaccaaagagccgaaactgga	9	9	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:128945037G>A	uc002tps.2	+	40	4669	c.4491G>A	c.(4489-4491)ATG>ATA	p.M1497I	UGGT1_uc002tpr.2_Missense_Mutation_p.M1473I	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1497	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						ATAATCCGATGACCAAAGAGC	0.463													0	0	0	0.010729	0	10	80										A	128945037	G	A	128945037	3	1	104	1	0	0	0	0	1	0	0	0	16938	1290	45	1	4649	1	UGGT1	2	128945037	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	473837	128945037	114254336	36	31990										
MCM6	4175	broad.mit.edu	37	chr2	136603937	136603937	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttgtagccattgatcccgttCacaggagcagggctgtcagc	12	11	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:136603937C>T	uc002tuw.2	-	15	2155	c.2079G>A	c.(2077-2079)GTG>GTA	p.V693V		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	693					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TGATCCCGTTCACAGGAGCAG	0.443													0	0	0	0.01441	0	154	146										T	136603937	C	T	136603937	2	4	104	1	0	0	0	0	0	0	0	1	9391	813	29	1		1	MCM6	2	136603937	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	7658900	136603937	106595436	37	31991										
SCN9A	6335	broad.mit.edu	37	chr2	167056103	167056103	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	atcatactgttgccaaaggtCtcaaaattgaacatgtcatt	6	8	3	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:167056103C>T	uc010fpl.2	-	27	5354	c.5013G>A	c.(5011-5013)GAG>GAA	p.E1671E	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1682	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCCAAAGGTCTCAAAATTGA	0.428													0	0	0	0.01441	0	61	114										T	167056103	C	T	167056103	2	4	104	1	0	0	0	0	0	0	0	1	13925	912	32	1		1	SCN9A	2	167056103	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	30452166	167056103	76143270	38	31992										
FRZB	2487	broad.mit.edu	37	chr2	183730874	183730874	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgtacactggcagctcctcgCaggccaggttctccggccac	11	17	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:183730874C>T	uc002upa.1	-	1	625	c.407G>A	c.(406-408)TGC>TAC	p.C136Y		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	136	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			CAGCTCCTCGCAGGCCAGGTT	0.637													0	0	0	0.006214	0	9	23										T	183730874	C	T	183730874	3	4	104	1	0	0	0	0	1	0	0	0	6065	710	25	2	594	2	FRZB	2	183730874	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	16674771	183730874	59468499	39	31993										
ANKAR	150709	broad.mit.edu	37	chr2	190554293	190554293	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gatccagactttaatgaaatCtatgatgaagacgtgaatga	9	5	1	7			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:190554293C>G	uc002uqw.1	+	2	429	c.429C>G	c.(427-429)ATC>ATG	p.I143M	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqv.1_Missense_Mutation_p.I214M	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	214						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TTAATGAAATCTATGATGAAG	0.303													0	0	0	0.003271	0	28	85										G	190554293	C	G	190554293	3	3	104	1	0	0	0	0	1	0	0	0	623	903	32	1	648	1	ANKAR	2	190554293	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	6823419	190554293	52645080	40	31994										
SATB2	23314	broad.mit.edu	37	chr2	200173580	200173580	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgacatccctctcatgctggGgaaggttcaggaagcgacgg	14	10	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:200173580G>A	uc002uuy.1	-	10	2460	c.1643C>T	c.(1642-1644)CCC>CTC	p.P548L	SATB2_uc010fsq.1_Missense_Mutation_p.P430L|SATB2_uc002uuz.1_Missense_Mutation_p.P548L|SATB2_uc002uva.1_Missense_Mutation_p.P548L	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	548	CUT 2.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCATGCTGGGGAAGGTTCAG	0.587													0	0	0	0.007835	0	39	97										A	200173580	G	A	200173580	3	1	104	1	0	0	0	0	1	0	0	0	13854	1232	43	2	566	2	SATB2	2	200173580	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	9619287	200173580	43025793	41	31995										
NOP58	51602	broad.mit.edu	37	chr2	203152401	203152401	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcctgtctcgatatagattGaagtttagcgctgataaagt	10	6	1	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:203152401G>T	uc002uzb.2	+	6	603	c.453G>T	c.(451-453)TTG>TTT	p.L151F		NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	151					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						GATATAGATTGAAGTTTAGCG	0.348													1	0	1.51926e-22	0.01441	1.62875e-22	37	119										T	203152401	G	T	203152401	3	4	104	1	0	0	0	0	1	0	0	0	10540	1281	45	3	475	3	NOP58	2	203152401	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	2978821	203152401	40046972	42	31996										
MARCH4	57574	broad.mit.edu	37	chr2	217124125	217124125	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aagtgactcaggatgtgcagGatggtataagcacagtggtg	15	5	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:217124125G>T	uc002vgb.2	-	4	2910	c.1143C>A	c.(1141-1143)ATC>ATA	p.I381I		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	381						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGATGTGCAGGATGGTATAAG	0.627													1	0	6.29468e-14	0.004878	6.57077e-14	33	41										T	217124125	G	T	217124125	2	4	104	1	0	0	0	0	0	0	0	1	9303	1164	41	3		3	MARCH4	2	217124125	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	13971724	217124125	26075248	43	31997										
WNT6	7475	broad.mit.edu	37	chr2	219736442	219736442	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggcgacgacgtggacttcggGgacgagaagtcgaggctctt	17	9	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:219736442G>A	uc002vjc.1	+	3	752	c.537G>A	c.(535-537)GGG>GGA	p.G179G		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	179					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGACTTCGGGGACGAGAAGT	0.547													0	0	0	0.001984	0	5	12										A	219736442	G	A	219736442	2	1	104	1	0	0	0	0	0	0	0	1	17390	1219	43	2		2	WNT6	2	219736442	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	2612317	219736442	23462931	44	31998										
CCDC108	255101	broad.mit.edu	37	chr2	219886644	219886644	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttcccaaaggccagctccttTtcctttgcctggaggccaca	8	15	0	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:219886644T>C	uc002vjl.1	-	18	3072	c.2988A>G	c.(2986-2988)GAA>GAG	p.E996E	CCDC108_uc002vjm.3_5'Flank	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	996						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGCTCCTTTTCCTTTGCCT	0.597													0	0	0	0.01441	0	118	19										C	219886644	T	C	219886644	2	2	104	1	0	0	0	0	0	0	0	1	2743	1838	64	5		5	CCDC108	2	219886644	Silent	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	150202	219886644	23312729	45	31999										
UGT1A3	54659	broad.mit.edu	37	chr2	234638530	234638530	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggatattctcagtcatgcatCtgtgtggctgttccgagggg	14	8	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr2:234638530C>T	uc002vuy.2	+	1	758	c.758C>T	c.(757-759)TCT>TTT	p.S253F	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.S253F	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	253					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGTCATGCATCTGTGTGGCTG	0.507													0	0	0	0.00623	0	33	213										T	234638530	C	T	234638530	3	4	104	1	0	0	0	0	1	0	0	0	16943	913	32	1	760	1	UGT1A3	2	234638530	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	14751886	234638530	8560843	46	32000										
ITPR1	3708	broad.mit.edu	37	chr3	4712527	4712527	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tggagggacagcaacaaagaGattcgcagcaagagtgtgag	15	6	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:4712527G>C	uc003bqa.2	+	20	2469	c.2121G>C	c.(2119-2121)GAG>GAC	p.E707D	ITPR1_uc010hca.1_Missense_Mutation_p.E692D|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.E692D	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	707	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCAACAAAGAGATTCGCAGCA	0.517													0	0	0	0.004482	0	9	35										C	4712527	G	C	4712527	3	2	104	1	0	0	0	0	1	0	0	0	7920	933	33	1	2191	1	ITPR1	3	4712527	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		4712527	193309903	47	32001										
SLC6A6	6533	broad.mit.edu	37	chr3	14508095	14508095	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtccgagggctgacgctgccGggcgcgggcgcaggcatcaa	18	13	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:14508095G>C	uc010heg.2	+	14	1095	c.804G>C	c.(802-804)CCG>CCC	p.P268P	SLC6A6_uc003byq.2_Silent_p.P268P|SLC6A6_uc003byr.2_RNA	NM_001134367	NP_001127839	P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter	268					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			ovary(1)	1						TGACGCTGCCGGGCGCGGGCG	0.617													0	0	0	0.004289	0	31	41										C	14508095	G	C	14508095	2	2	104	1	0	0	0	0	0	0	0	1	14688	1103	39	4		4	SLC6A6	3	14508095	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	9795568	14508095	183514335	48	32002										
NR2C2	7182	broad.mit.edu	37	chr3	15045491	15045491	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tagcctcacctcagcgcattCaggtacctgcaacctgccaa	7	16	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:15045491C>T	uc003bzj.3	+	2	287	c.70C>T	c.(70-72)CAG>TAG	p.Q24*	NR2C2_uc003bzi.2_Nonsense_Mutation_p.Q24*	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	24					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						TCAGCGCATTCAGGTACCTGC	0.527													0	0	0	0.00632	0	23	129										T	15045491	C	T	15045491	4	4	104	1	0	0	0	0	0	1	0	0	10623	827	29	1	72	1	NR2C2	3	15045491	Nonsense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	537396	15045491	182976939	49	32003										
BAP1	8314	broad.mit.edu	37	chr3	52439230	52439230	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	attgaggctgctgcctggagGcttcaccactagcttgggtt	13	10	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:52439230G>A	uc003ddx.2	-	11	1127	c.1012C>T	c.(1012-1014)CCT>TCT	p.P338S	BAP1_uc003ddw.2_5'Flank|BAP1_uc010hmg.2_5'Flank|BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	338					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CTGCCTGGAGGCTTCACCACT	0.587			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.01441	0	85	106										A	52439230	G	A	52439230	3	1	104	1	0	0	0	0	1	0	0	0	1311	1203	42	2	1205	2	BAP1	3	52439230	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	37393739	52439230	145583200	50	32004										
SEMA3G	56920	broad.mit.edu	37	chr3	52474095	52474095	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	caaaaggccgtcctggctgtGcggtcatcttgctggggcac	14	12	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:52474095G>T	uc003dea.1	-	11	1163	c.1163C>A	c.(1162-1164)GCA>GAA	p.A388E		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	388	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		TCCTGGCTGTGCGGTCATCTT	0.622													1	0	1.15088e-07	0.004007	1.18575e-07	15	20										T	52474095	G	T	52474095	3	4	104	1	0	0	0	0	1	0	0	0	14030	1319	46	4	1209	4	SEMA3G	3	52474095	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	34865	52474095	145548335	51	32005										
CADM2	253559	broad.mit.edu	37	chr3	86115879	86115879	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gatgctgatacagccattatCaatgctgaaggcagccaagt	10	9	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:86115879C>G	uc003dqj.2	+	10	1880	c.1254C>G	c.(1252-1254)ATC>ATG	p.I418M	CADM2_uc003dqk.2_Missense_Mutation_p.I387M|CADM2_uc003dql.2_Missense_Mutation_p.I420M|uc003dqm.1_5'Flank	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	418	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CAGCCATTATCAATGCTGAAG	0.393													0	0	0	0.007291	0	28	36										G	86115879	C	G	86115879	3	3	104	1	0	0	0	0	1	0	0	0	2567	816	29	1	1363	1	CADM2	3	86115879	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	33641784	86115879	111906551	52	32006										
ZNF80	7634	broad.mit.edu	37	chr3	113955575	113955575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcacaggaggtgcgacctgCggttgaagaccttcccgcac	13	13	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:113955575C>T	uc010hqo.2	-	1	851	c.347G>A	c.(346-348)CGC>CAC	p.R116H	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	116	C2H2-type 3; atypical.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GTGCGACCTGCGGTTGAAGAC	0.542													0	0	0	0.008871	0	16	29										T	113955575	C	T	113955575	3	4	104	1	0	0	0	0	1	0	0	0	18165	768	27	2	478	2	ZNF80	3	113955575	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	27839696	113955575	84066855	53	32007										
HPS3	84343	broad.mit.edu	37	chr3	148871395	148871395	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttttgactaaagcagaacctGaagccattccagagagaaga	9	8	0	6			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr3:148871395G>A	uc003ewu.1	+	7	1500	c.1360G>A	c.(1360-1362)GAA>AAA	p.E454K	HPS3_uc003ewt.1_Missense_Mutation_p.E454K|HPS3_uc011bnq.1_Missense_Mutation_p.E289K	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	454						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGCAGAACCTGAAGCCATTCC	0.438									Hermansky-Pudlak_syndrome				0	0	0	0.014323	0	20	57										A	148871395	G	A	148871395	3	1	104	1	0	0	0	0	1	0	0	0	7340	1291	45	1	1386	1	HPS3	3	148871395	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	34915820	148871395	49151035	54	32008										
TXK	7294	broad.mit.edu	37	chr4	48082134	48082134	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaagttgcactagctttgaaTgagataatttcctggtgaag	10	5	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:48082134T>A	uc003gxx.3	-	11	1054	c.968A>T	c.(967-969)CAT>CTT	p.H323L	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Missense_Mutation_p.H10L	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	323	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TAGCTTTGAATGAGATAATTT	0.373													0	0	0	0.004482	0	8	30										A	48082134	T	A	48082134	3	1	104	1	0	0	0	0	1	0	0	0	16783	1464	51	5	635	5	TXK	4	48082134	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08		48082134	143072142	55	32009										
PPEF2	5470	broad.mit.edu	37	chr4	76797581	76797581	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgctctagctccagttccacGgagctccgcacctgccggga	11	17	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:76797581G>A	uc003hix.2	-	11	1536	c.1179C>T	c.(1177-1179)TCC>TCT	p.S393S	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Silent_p.S393S	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	393	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCAGTTCCACGGAGCTCCGCA	0.657													0	0	0	0.004007	0	15	21										A	76797581	G	A	76797581	2	1	104	1	0	0	0	0	0	0	0	1	12308	1103	39	2		2	PPEF2	4	76797581	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	28715447	76797581	114356695	56	32010										
ANK2	287	broad.mit.edu	37	chr4	114284603	114284603	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctgttgaagtactggctagaGagggatgggaaacatgctac	14	6	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:114284603G>A	uc003ibe.3	+	40	10966	c.10866G>A	c.(10864-10866)GAG>GAA	p.E3622E	ANK2_uc003ibd.3_Silent_p.E1528E|ANK2_uc003ibf.3_Silent_p.E1537E|ANK2_uc011cgc.1_Silent_p.E713E|ANK2_uc003ibg.3_Silent_p.E521E|ANK2_uc003ibh.3_Silent_p.E211E|ANK2_uc011cgd.1_Silent_p.E924E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3589	Death.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ACTGGCTAGAGAGGGATGGGA	0.428													0	0	0	0.012319	0	17	123										A	114284603	G	A	114284603	2	1	104	1	0	0	0	0	0	0	0	1	621	933	33	1		1	ANK2	4	114284603	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	37487022	114284603	76869673	57	32011										
FGG	2266	broad.mit.edu	37	chr4	155531252	155531252	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	atcatggatttgcaccgtgtCtttgcaaggttcctggcact	10	10	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:155531252C>T	uc003ioj.2	-	5	640	c.499G>A	c.(499-501)GAC>AAC	p.D167N	FGG_uc003iog.2_Missense_Mutation_p.D167N|FGG_uc003ioh.2_Missense_Mutation_p.D167N|FGG_uc010ipx.2_Intron|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'UTR|FGG_uc003iok.2_Missense_Mutation_p.D167N	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	167					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGCACCGTGTCTTTGCAAGGT	0.363													0	0	0	0.004878	0	33	47										T	155531252	C	T	155531252	3	4	104	1	0	0	0	0	1	0	0	0	5870	913	32	1	901	1	FGG	4	155531252	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	41246649	155531252	35623024	58	32012										
SLC25A4	291	broad.mit.edu	37	chr4	186067010	186067011	+	Frame_Shift_Ins	INS	-	-	A													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tggtgtcctacccctttgacINSactgttcgtcgtagaatgat							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:186067010_186067011insA	uc003ixd.2	+	3	825_826	c.696_697insA	c.(694-699)GACACTfs	p.D232fs	SLC25A4_uc003ixe.2_RNA	NM_001151	NP_001142	P12235	ADT1_HUMAN	adenine nucleotide translocator 1	232_233	Helical; Name=5; (By similarity).|Solcar 3.				energy reserve metabolic process|interspecies interaction between organisms|mitochondrial genome maintenance|negative regulation of necrotic cell death|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane	adenine transmembrane transporter activity|protein binding			ovary(1)	1		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;4.48e-44)|Epithelial(43;2.1e-41)|all cancers(43;1.37e-36)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)	Adenosine triphosphate(DB00171)|Clodronate(DB00720)	ACCCCTTTGACACTGTTCGTCG	0.52																		30	12	---	---								A	186067011	-	A	186067010	7	5	104	1	0	1	1	0	0	0	0	0	14504	477	17	0	706	0	SLC25A4	4	186067010	Frame_Shift_Ins	INS	-	TCGA-GC-A3RB-01A-12D-A21Z-08	30535758	186067010	5087266	59	32013										
CCDC110	256309	broad.mit.edu	37	chr4	186380148	186380148	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgttgcttctctaaagaaagTtgtatatttttttcctctag	6	6	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr4:186380148T>C	uc003ixu.3	-	6	1669	c.1593A>G	c.(1591-1593)CAA>CAG	p.Q531Q	CCDC110_uc003ixv.3_Silent_p.Q494Q|CCDC110_uc011ckt.1_Silent_p.Q531Q	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	531	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		CTAAAGAAAGTTGTATATTTT	0.264													0	0	0	0.014323	0	23	8										C	186380148	T	C	186380148	2	2	104	1	0	0	0	0	0	0	0	1	2747	1722	60	5		5	CCDC110	4	186380148	Silent	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	313138	186380148	4774128	60	32014										
IRX1	79192	broad.mit.edu	37	chr5	3600252	3600252	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cttcctgggcgttggcgctcCccacgccgcgccccatggcc	12	20	0	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:3600252C>T	uc003jde.2	+	2	1242	c.1190C>T	c.(1189-1191)CCC>CTC	p.P397L		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GTTGGCGCTCCCCACGCCGCG	0.662													0	0	0	0.003163	0	12	63										T	3600252	C	T	3600252	3	4	104	1	0	0	0	0	1	0	0	0	7843	623	22	2	1196	2	IRX1	5	3600252	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		3600252	177315008	61	32015										
FASTKD3	79072	broad.mit.edu	37	chr5	7861273	7861273	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaaccgtacctgaacaacttGataaccgagtaactgtaggt	8	9	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:7861273G>C	uc003jeb.2	-	6	2010	c.1873C>G	c.(1873-1875)CAA>GAA	p.Q625E	FASTKD3_uc011cmp.1_Missense_Mutation_p.Q327E|FASTKD3_uc003jec.2_RNA	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	625	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TGAACAACTTGATAACCGAGT	0.323													0	0	0	0.01441	0	53	68										C	7861273	G	C	7861273	3	2	104	1	0	0	0	0	1	0	0	0	5687	1299	45	1	123	1	FASTKD3	5	7861273	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	4261021	7861273	173053987	62	32016										
RAD17	5884	broad.mit.edu	37	chr5	68684860	68684860	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aatttaattttcttattttaGaatggaggaaaaattactgt	6	2	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:68684860G>A	uc003jwo.2	+	9	990	c.928_splice	c.e9-1	p.N310_splice	RAD17_uc003jwg.2_Splice_Site_p.N299_splice|RAD17_uc003jwh.2_Splice_Site_p.N299_splice|RAD17_uc003jwi.2_Splice_Site_p.N299_splice|RAD17_uc003jwj.2_Splice_Site_p.N299_splice|RAD17_uc003jwk.2_Splice_Site_p.N299_splice|RAD17_uc003jwl.2_Splice_Site_p.N299_splice|RAD17_uc003jwm.2_Splice_Site_p.N134_splice|RAD17_uc003jwn.2_Splice_Site_p.N213_splice	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2						cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		tcttattttaGAATGGAGGAA	0.279								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.009096	0	4	34										A	68684860	G	A	68684860	5	1	104	1	0	0	0	0	0	0	1	0	12979	956	33	1	974	1	RAD17	5	68684860	Splice_Site	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	60823587	68684860	112230400	63	32017										
LYSMD3	116068	broad.mit.edu	37	chr5	89815210	89815210	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gacaaagtgtttcggtcaagGaactgaacttttttactgga	10	6	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:89815210G>A	uc003kjr.2	-	3	495	c.347C>T	c.(346-348)TCC>TTC	p.S116F	LYSMD3_uc010jaz.1_Intron|LYSMD3_uc003kjs.1_Silent_p.F96F	NM_198273	NP_938014	Q7Z3D4	LYSM3_HUMAN	LysM, putative peptidoglycan-binding, domain	116	Extracellular (Potential).				cell wall macromolecule catabolic process	integral to membrane					0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.94e-31)|Epithelial(54;5.22e-26)|all cancers(79;2.42e-22)		TTCGGTCAAGGAACTGAACTT	0.398													0	0	0	0.007291	0	25	58										A	89815210	G	A	89815210	3	1	104	1	0	0	0	0	1	0	0	0	9126	1174	41	1	577	1	LYSMD3	5	89815210	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	21130350	89815210	91100050	64	32018										
CLTB	1212	broad.mit.edu	37	chr5	175823491	175823491	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gacacgtacacgtagccgatGatatcagcatctggctgctg	11	11	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:175823491G>A	uc003meh.2	-	6	682	c.507C>T	c.(505-507)ATC>ATT	p.I169I	CLTB_uc003mei.2_Intron|CLTB_uc011dfn.1_Intron	NM_007097	NP_009028	P09497	CLCB_HUMAN	clathrin, light polypeptide isoform b	169					intracellular protein transport|vesicle-mediated transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle	protein binding|structural molecule activity				0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.098)		CGTAGCCGATGATATCAGCAT	0.348													0	0	0	0.012319	0	19	32										A	175823491	G	A	175823491	2	1	104	1	0	0	0	0	0	0	0	1	3565	1280	45	1		1	CLTB	5	175823491	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	86008281	175823491	5091769	65	32019										
RGS14	10636	broad.mit.edu	37	chr5	176793178	176793178	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acttgtccatccccctgcagAgctgagcagcacgacggggc	12	15	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr5:176793178A>T	uc003mgf.2	+	3	250	c.68A>T	c.(67-69)GAG>GTG	p.E23V	RGS14_uc003mgg.1_5'Flank|RGS14_uc003mgh.2_5'Flank|RGS14_uc003mgi.2_5'Flank	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	23					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCCTGCAGAGCTGAGCAGC	0.682													0	0	0	0.001855	0	9	33										T	176793178	A	T	176793178	3	4	104	1	0	0	0	0	1	0	0	0	13297	318	11	5	78	5	RGS14	5	176793178	Missense_Mutation	SNP	A	TCGA-GC-A3RB-01A-12D-A21Z-08	969687	176793178	4122082	66	32020										
FOXQ1	94234	broad.mit.edu	37	chr6	1313374	1313376	+	In_Frame_Del	DEL	CAA	CAA	-													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgcttgacgctggcggagatCaacgagtacctcatgggcaa							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			CAA	-	CAA	CAA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:1313374_1313376delCAA	uc003mtl.3	+	1	700_702	c.435_437delCAA	c.(433-438)ATCAAC>ATC	p.N146del		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	146	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TGGCGGAGATCAACGAGTACCTC	0.64																		22	88	---	---								-	1313376	CAA	-	1313374	7	5	104	1	0	1	0	1	0	0	0	0	6030	816	29	0	437	0	FOXQ1	6	1313374	In_Frame_Del	DEL	CAA	TCGA-GC-A3RB-01A-12D-A21Z-08		1313374	169801693	67	32021										
HIST1H3I	8354	broad.mit.edu	37	chr6	27839778	27839778	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggcgcacaggttggtatcctCaaatagccccaccaggtagg	12	12	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:27839778C>G	uc003njy.2	-	1	322	c.316G>C	c.(316-318)GAG>CAG	p.E106Q		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	106					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						TTGGTATCCTCAAATAGCCCC	0.572													0	0	0	0.01441	0	58	82										G	27839778	C	G	27839778	3	3	104	1	0	0	0	0	1	0	0	0	7163	835	29	1	98	1	HIST1H3I	6	27839778	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	26526404	27839778	143275289	68	32022										
CDSN	1041	broad.mit.edu	37	chr6	31084799	31084799	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ataccccaaaggtctgggaaGaggaagagctttgtccaggc	13	9	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:31084799G>C	uc003nsm.1	-	2	620	c.593C>G	c.(592-594)TCT>TGT	p.S198C	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	198	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						GGTCTGGGAAGAGGAAGAGCT	0.572													0	0	0	0.01441	0	11	106										C	31084799	G	C	31084799	3	2	104	1	0	0	0	0	1	0	0	0	3179	942	33	1	1000	1	CDSN	6	31084799	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	3245021	31084799	140030268	69	32023										
FAM46A	55603	broad.mit.edu	37	chr6	82459570	82459570	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	attaggaatgacattttggtCagctaacacccggatagcca	9	9	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:82459570C>T	uc003pjg.2	-	3	1489	c.1171G>A	c.(1171-1173)GAC>AAC	p.D391N	FAM46A_uc003pjf.2_Missense_Mutation_p.D410N	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	391											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		ACATTTTGGTCAGCTAACACC	0.453													0	0	0	0.01441	0	52	10										T	82459570	C	T	82459570	3	4	104	1	0	0	0	0	1	0	0	0	5565	826	29	1	161	1	FAM46A	6	82459570	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	51374771	82459570	88655497	70	32024										
CASP8AP2	9994	broad.mit.edu	37	chr6	90573259	90573259	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	catatgttccctccataagtGaacatatcttgggggaagca	9	9	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:90573259G>A	uc003pnr.2	+	7	2027	c.1831G>A	c.(1831-1833)GAA>AAA	p.E611K	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E611K|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E611K	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	611					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTCCATAAGTGAACATATCTT	0.423													0	0	0	0.009535	0	23	2										A	90573259	G	A	90573259	3	1	104	1	0	0	0	0	1	0	0	0	2678	1291	45	1	1853	1	CASP8AP2	6	90573259	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	8113689	90573259	80541808	71	32025										
FUT9	10690	broad.mit.edu	37	chr6	96651476	96651476	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctccccaaaagagtggcattGagcacttgtttaacctgact	8	11	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:96651476G>A	uc003pop.3	+	3	786	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	149	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GAGTGGCATTGAGCACTTGTT	0.453													0	0	0	0.00333	0	21	29										A	96651476	G	A	96651476	3	1	104	1	0	0	0	0	1	0	0	0	6111	1291	45	1	447	1	FUT9	6	96651476	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	6078217	96651476	74463591	72	32026										
SMPD2	6610	broad.mit.edu	37	chr6	109763792	109763792	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggacatctacctagcacatcGtgtggcccaagcttgggaat	11	11	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr6:109763792G>C	uc003pti.2	+	6	849	c.455G>C	c.(454-456)CGT>CCT	p.R152P	PPIL6_uc003ptg.3_5'Flank|PPIL6_uc010kdo.2_5'Flank|PPIL6_uc010kdp.2_5'Flank|PPIL6_uc003pth.1_5'Flank	NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	152					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		CTAGCACATCGTGTGGCCCAA	0.542													0	0	0	0.008291	0	8	90										C	109763792	G	C	109763792	3	2	104	1	0	0	0	0	1	0	0	0	14805	1145	40	4	477	4	SMPD2	6	109763792	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	13112316	109763792	61351275	73	32027										
GPER	2852	broad.mit.edu	37	chr7	1131766	1131766	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtcctgtgcaccttcatgtcGctcttcctgcaggtcaacat	8	14	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:1131766G>A	uc010ksd.1	+	2	791	c.402G>A	c.(400-402)TCG>TCA	p.S134S	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Silent_p.S134S|GPER_uc003ska.1_Silent_p.S134S|GPER_uc003skb.2_Silent_p.S134S	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	134	Helical; Name=3; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CCTTCATGTCGCTCTTCCTGC	0.607													0	0	0	0.004289	0	31	118										A	1131766	G	A	1131766	2	1	104	1	0	0	0	0	0	0	0	1	6607	1074	38	2		2	GPER	7	1131766	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		1131766	158006897	74	32028										
TNRC18	84629	broad.mit.edu	37	chr7	5410707	5410707	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcagcggcgactccagaggcGgcagctctgtggggccctcg	17	14	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:5410707G>A	uc003soi.3	-	11	3867	c.3518C>T	c.(3517-3519)CCG>CTG	p.P1173L		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1173	Pro-rich.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CTCCAGAGGCGGCAGCTCTGT	0.706													0	0	0	0.008871	0	18	62										A	5410707	G	A	5410707	3	1	104	1	0	0	0	0	1	0	0	0	16336	1116	39	2	5468	2	TNRC18	7	5410707	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	4278941	5410707	153727956	75	32029										
FAM188B	84182	broad.mit.edu	37	chr7	30891838	30891838	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cctttcctttttagggcttcGagaacacagcagttcagtcc	8	12	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:30891838G>C	uc003tbt.2	+	11	1631	c.1554G>C	c.(1552-1554)TCG>TCC	p.S518S	FAM188B_uc010kwe.2_Silent_p.S489S|AQP1_uc011kac.1_5'Flank	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	518											0						TTAGGGCTTCGAGAACACAGC	0.463													0	0	0	0.00333	0	18	113										C	30891838	G	C	30891838	2	2	104	1	0	0	0	0	0	0	0	1	5515	1045	37	1		1	FAM188B	7	30891838	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	25481131	30891838	128246825	76	32030										
BBS9	27241	broad.mit.edu	37	chr7	33376191	33376191	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gatgaacttgatgtagaaatGaaagaacttcagaaaatcat	8	4	2	6			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:33376191G>A	uc003tdn.1	+	10	1668	c.1155G>A	c.(1153-1155)ATG>ATA	p.M385I	BBS9_uc003tdo.1_Missense_Mutation_p.M385I|BBS9_uc003tdp.1_Missense_Mutation_p.M385I|BBS9_uc003tdq.1_Missense_Mutation_p.M385I|BBS9_uc010kwn.1_RNA|BBS9_uc011kao.1_Missense_Mutation_p.M263I	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	385					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			ATGTAGAAATGAAAGAACTTC	0.333									Bardet-Biedl_syndrome				0	0	0	0.009096	0	4	29										A	33376191	G	A	33376191	3	1	104	1	0	0	0	0	1	0	0	0	1342	1290	45	1	1189	1	BBS9	7	33376191	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	2484353	33376191	125762472	77	32031										
PURB	5814	broad.mit.edu	37	chr7	44924070	44924070	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgccgctgcccccaccacgtCgctcataaagcttatccctc	6	20	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:44924070C>A	uc003tme.2	-	1	891	c.878G>T	c.(877-879)CGA>CTA	p.R293L		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	293					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCCACCACGTCGCTCATAAAG	0.587													1	0	2.29192e-23	0.01441	2.46822e-23	41	148										A	44924070	C	A	44924070	3	1	104	1	0	0	0	0	1	0	0	0	12828	884	31	3	64	3	PURB	7	44924070	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	11547879	44924070	114214593	78	32032										
FZD1	8321	broad.mit.edu	37	chr7	90896136	90896136	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaacaaggggagactacagtCtgagacccggggctcagccc	13	12	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:90896136C>T	uc003ula.2	+	1	2354	c.1941C>T	c.(1939-1941)GTC>GTT	p.V647V		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	647	PDZ-binding.|Cytoplasmic (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			AGACTACAGTCTGAGACCCGG	0.627													0	0	0	0.004289	0	32	89										T	90896136	C	T	90896136	2	4	104	1	0	0	0	0	0	0	0	1	6128	900	32	1		1	FZD1	7	90896136	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	45972066	90896136	68242527	79	32033										
ACHE	43	broad.mit.edu	37	chr7	100490233	100490233	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acatcgctcagggcctccctCaggcgtgccgggtcctcggg	14	16	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:100490233C>T	uc003uxd.2	-	2	1431	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	UFSP1_uc003uxc.3_5'Flank|ACHE_uc003uxe.2_Silent_p.L425L|ACHE_uc003uxf.2_Silent_p.L425L|ACHE_uc003uxg.2_Silent_p.L425L|ACHE_uc003uxh.2_Intron|ACHE_uc003uxi.2_Silent_p.L425L	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	425					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	GGGCCTCCCTCAGGCGTGCCG	0.697													0	0	0	0.006214	0	8	33										T	100490233	C	T	100490233	2	4	104	1	0	0	0	0	0	0	0	1	141	813	29	1		1	ACHE	7	100490233	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	9594097	100490233	58648430	80	32034										
ACHE	43	broad.mit.edu	37	chr7	100491541	100491541	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaaacctgggtatagggtgtCcacatattggtagcagacac	11	8	0	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr7:100491541C>A	uc003uxd.2	-	1	469	c.313G>T	c.(313-315)GAC>TAC	p.D105Y	ACHE_uc003uxe.2_Missense_Mutation_p.D105Y|ACHE_uc003uxf.2_Missense_Mutation_p.D105Y|ACHE_uc003uxg.2_Missense_Mutation_p.D105Y|ACHE_uc003uxh.2_Missense_Mutation_p.D105Y|ACHE_uc003uxi.2_Missense_Mutation_p.D105Y|ACHE_uc003uxj.1_Missense_Mutation_p.D224Y	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	105					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TATAGGGTGTCCACATATTGG	0.592													1	0	1.81118e-26	0.01441	1.95937e-26	45	167										A	100491541	C	A	100491541	3	1	104	1	0	0	0	0	1	0	0	0	141	855	30	3	1682	3	ACHE	7	100491541	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	1308	100491541	58647122	81	32035										
ATP6V1H	51606	broad.mit.edu	37	chr8	54708314	54708314	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccgcaggtgttcacacatttGaggactgaatgccaggagcc	12	11	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:54708314G>C	uc003xrl.2	-	9	915	c.763C>G	c.(763-765)CAA>GAA	p.Q255E	ATP6V1H_uc003xrk.2_Missense_Mutation_p.Q215E|ATP6V1H_uc003xrm.2_Missense_Mutation_p.Q255E|ATP6V1H_uc003xrn.2_Missense_Mutation_p.Q237E|ATP6V1H_uc011ldv.1_Missense_Mutation_p.Q175E|ATP6V1H_uc010lyd.2_Missense_Mutation_p.Q191E	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	255					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TCACACATTTGAGGACTGAAT	0.403													0	0	0	0.01441	0	62	81										C	54708314	G	C	54708314	3	2	104	1	0	0	0	0	1	0	0	0	1189	1299	45	1	712	1	ATP6V1H	8	54708314	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		54708314	91655708	82	32036										
TRPA1	8989	broad.mit.edu	37	chr8	72981353	72981353	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtttgctcctctgctgagaaGaaacttaacgctttcaattt	7	9	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:72981353G>A	uc003xza.2	-	3	524	c.349C>T	c.(349-351)CTT>TTT	p.L117F		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	117	Cytoplasmic (Potential).|ANK 2.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGCTGAGAAGAAACTTAACG	0.413													0	0	0	0.009718	0	44	187										A	72981353	G	A	72981353	3	1	104	1	0	0	0	0	1	0	0	0	16574	942	33	1	3110	1	TRPA1	8	72981353	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	18273039	72981353	73382669	83	32037										
KIAA1429	25962	broad.mit.edu	37	chr8	95523769	95523769	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgttaacatagttttaagaaGagtgagtgtgcagcgagcca	12	6	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:95523769G>A	uc003ygo.1	-	13	3047	c.3034C>T	c.(3034-3036)CTT>TTT	p.L1012F	KIAA1429_uc003ygp.2_Missense_Mutation_p.L1012F|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1012					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GTTTTAAGAAGAGTGAGTGTG	0.448													0	0	0	0.007413	0	18	209										A	95523769	G	A	95523769	3	1	104	1	0	0	0	0	1	0	0	0	8231	942	33	1	2506	1	KIAA1429	8	95523769	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	22542416	95523769	50840253	84	32038										
PABPC1	26986	broad.mit.edu	37	chr8	101719200	101719200	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggtctaggagcagctgggcgGatagcaccgggcatattttg	16	8	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:101719200G>A	uc003yjs.1	-	10	1866	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	PABPC1_uc011lhc.1_Silent_p.I422I|PABPC1_uc011lhd.1_Silent_p.I409I|PABPC1_uc003yjt.1_Silent_p.I451I|PABPC1_uc003yju.2_Intron	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	454					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CAGCTGGGCGGATAGCACCGG	0.433													0	0	0	0.010504	0	20	120										A	101719200	G	A	101719200	2	1	104	1	0	0	0	0	0	0	0	1	11363	1164	41	1		1	PABPC1	8	101719200	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	6195431	101719200	44644822	85	32039										
TRPS1	7227	broad.mit.edu	37	chr8	116616194	116616194	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cttgacagactgctgcccatCcgatccttgcaggtgatttg	10	12	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:116616194C>G	uc003ynz.2	-	3	2422	c.1963G>C	c.(1963-1965)GAT>CAT	p.D655H	TRPS1_uc011lhy.1_Missense_Mutation_p.D659H|TRPS1_uc003yny.2_Missense_Mutation_p.D668H|TRPS1_uc010mcy.2_Missense_Mutation_p.D655H	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	655	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGCTGCCCATCCGATCCTTGC	0.463									Langer-Giedion_syndrome				0	0	0	0.003163	0	15	94										G	116616194	C	G	116616194	3	3	104	1	0	0	0	0	1	0	0	0	16590	855	30	1	1898	1	TRPS1	8	116616194	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	14896994	116616194	29747828	86	32040										
TG	7038	broad.mit.edu	37	chr8	133913623	133913623	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcctctgcaatgtgctcaaGagtggagtcctctccaggag	12	11	3	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:133913623G>C	uc003ytw.2	+	16	3500	c.3459G>C	c.(3457-3459)AAG>AAC	p.K1153N	TG_uc010mdw.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1153	Thyroglobulin type-1 10.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATGTGCTCAAGAGTGGAGTCC	0.607													0	0	0	0.01441	0	66	136										C	133913623	G	C	133913623	3	2	104	1	0	0	0	0	1	0	0	0	15810	933	33	1	3521	1	TG	8	133913623	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	17297429	133913623	12450399	87	32041										
KIFC2	90990	broad.mit.edu	37	chr8	145697780	145697780	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gggcctcccgagcgcctggcCgtgaggcagggcccagaagg	18	14	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:145697780C>G	uc003zcz.2	+	15	1709	c.1644C>G	c.(1642-1644)GCC>GCG	p.A548A	KIFC2_uc003zda.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	548	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGCGCCTGGCCGTGAGGCAGG	0.657													0	0	0	0.001168	0	5	23										G	145697780	C	G	145697780	2	3	104	1	0	0	0	0	0	0	0	1	8313	639	23	4		4	KIFC2	8	145697780	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	11784157	145697780	666242	88	32042										
GPT	2875	broad.mit.edu	37	chr8	145732224	145732224	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cgggaaggcacctaccacttCcggtgaggcctggccctcac	12	16	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr8:145732224C>T	uc011lli.1	+	11	1555	c.1398C>T	c.(1396-1398)TTC>TTT	p.F466F	GPT_uc003zdh.3_Silent_p.F466F|MFSD3_uc003zdi.1_5'Flank	NM_005309	NP_005300	P24298	ALAT1_HUMAN	glutamic pyruvate transaminase	466					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|central_nervous_system(1)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCTACCACTTCCGGTGAGGCC	0.637													0	0	0	0.010771	0	40	9										T	145732224	C	T	145732224	2	4	104	1	0	0	0	0	0	0	0	1	6737	854	30	1		1	GPT	8	145732224	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	34444	145732224	631798	89	32043										
ACO1	48	broad.mit.edu	37	chr9	32450097	32450097	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctcaactacatgatccgcaaGatggccaagtaggagacgtg	11	10	1	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:32450097G>C	uc003zqw.3	+	21	2813	c.2658G>C	c.(2656-2658)AAG>AAC	p.K886N	ACO1_uc003zqx.3_Missense_Mutation_p.K886N|ACO1_uc003zqy.3_RNA	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1	886					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TGATCCGCAAGATGGCCAAGT	0.592													0	0	0	0.014323	0	21	42										C	32450097	G	C	32450097	3	2	104	1	0	0	0	0	1	0	0	0	146	933	33	1	2736	1	ACO1	9	32450097	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		32450097	108763334	90	32044										
UBAP2	55833	broad.mit.edu	37	chr9	33943441	33943441	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaagacttcgaatacaagctGatgggaatctgattactatt	8	6	1	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:33943441G>A	uc003ztq.1	-	15	1805	c.1692C>T	c.(1690-1692)ATC>ATT	p.I564I	UBAP2_uc011loc.1_Silent_p.I473I|UBAP2_uc011lod.1_Silent_p.I297I|UBAP2_uc011loe.1_Silent_p.I319I|UBAP2_uc011lof.1_Silent_p.I489I|UBAP2_uc011log.1_Silent_p.I510I|UBAP2_uc003ztr.2_Silent_p.I436I|UBAP2_uc003zts.2_Silent_p.I197I	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	564										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		AATACAAGCTGATGGGAATCT	0.393													0	0	0	0.008361	0	27	60										A	33943441	G	A	33943441	2	1	104	1	0	0	0	0	0	0	0	1	16834	1280	45	1		1	UBAP2	9	33943441	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1493344	33943441	107269990	91	32045										
UBAP2	55833	broad.mit.edu	37	chr9	34017107	34017107	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgaaatctgtggtttttcccGagcacctcgacaatggtcac	9	11	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:34017107G>A	uc003ztq.1	-	2	153	c.40C>T	c.(40-42)CGG>TGG	p.R14W	UBAP2_uc011loc.1_5'UTR|UBAP2_uc011lod.1_Intron|UBAP2_uc011loe.1_5'UTR|UBAP2_uc011lof.1_5'UTR|UBAP2_uc011log.1_Missense_Mutation_p.R13W|UBAP2_uc003ztr.2_5'UTR	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	14										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GGTTTTTCCCGAGCACCTCGA	0.353													0	0	0	0.006122	0	15	80										A	34017107	G	A	34017107	3	1	104	1	0	0	0	0	1	0	0	0	16834	1057	37	1	3431	1	UBAP2	9	34017107	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	73666	34017107	107196324	92	32046										
DNAJB5	25822	broad.mit.edu	37	chr9	34996695	34996695	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aagatcctgcacatagtcatCaagcgtggctggaaggaagg	13	8	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:34996695C>G	uc003zvt.2	+	3	783	c.645C>G	c.(643-645)ATC>ATG	p.I215M	DNAJB5_uc003zvs.2_Missense_Mutation_p.I249M|DNAJB5_uc011los.1_Missense_Mutation_p.I287M	NM_012266	NP_036398	O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	215					protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(32;0.00575)			ACATAGTCATCAAGCGTGGCT	0.552													0	0	0	0.013537	0	11	34										G	34996695	C	G	34996695	3	3	104	1	0	0	0	0	1	0	0	0	4623	816	29	1	871	1	DNAJB5	9	34996695	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	979588	34996695	106216736	93	32047										
FAM75A6	389730	broad.mit.edu	37	chr9	43624988	43624988	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cagactggggcttgaaacttCtgtttgtgctgatttacctt	10	8	1	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:43624988C>G	uc011lrb.1	-	4	3728	c.3699G>C	c.(3697-3699)CAG>CAC	p.Q1233H		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1233						integral to membrane					0						CTTGAAACTTCTGTTTGTGCT	0.502													0	0	0	0.01441	0	86	507										G	43624988	C	G	43624988	3	3	104	1	0	0	0	0	1	0	0	0	5622	912	32	1	336	1	FAM75A6	9	43624988	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	8628293	43624988	97588443	94	32048										
APBA1	320	broad.mit.edu	37	chr9	72131394	72131394	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cttctcggggctgtcggactCgccgtcggagcgctcgtcgt	15	14	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:72131394C>T	uc004ahh.2	-	2	1009	c.733G>A	c.(733-735)GAG>AAG	p.E245K		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	245	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						CTGTCGGACTCGCCGTCGGAG	0.701													0	0	0	0.012319	0	16	27										T	72131394	C	T	72131394	3	4	104	1	0	0	0	0	1	0	0	0	756	893	31	1	1828	1	APBA1	9	72131394	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	28506406	72131394	69082037	95	32049										
FAM120A	23196	broad.mit.edu	37	chr9	96214620	96214620	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaggtctggttcctgccgccCgtctgcatggcccactgcat	11	15	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:96214620C>G	uc004atw.2	+	1	448	c.423C>G	c.(421-423)CCC>CCG	p.P141P	FAM120AOS_uc004atm.2_5'Flank|FAM120AOS_uc004atn.3_5'Flank|FAM120AOS_uc004ato.3_5'Flank|FAM120AOS_uc004atp.3_5'Flank|FAM120AOS_uc004atq.3_5'Flank|FAM120AOS_uc004atr.3_5'Flank|FAM120AOS_uc004ats.3_Intron|FAM120AOS_uc004att.3_Intron|FAM120AOS_uc004atu.3_Silent_p.T124T|FAM120A_uc004atv.2_Silent_p.P141P	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	141						cytoplasm|plasma membrane	RNA binding				0						TCCTGCCGCCCGTCTGCATGG	0.567													0	0	0	0.00308	0	6	41										G	96214620	C	G	96214620	2	3	104	1	0	0	0	0	0	0	0	1	5415	639	23	4		4	FAM120A	9	96214620	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	24083226	96214620	44998811	96	32050										
FPGS	2356	broad.mit.edu	37	chr9	130570856	130570856	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtgtcctctatacctgtgtcCgatgctggaggccctcgagg	13	12	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:130570856C>T	uc004bsg.1	+	10	892	c.842C>T	c.(841-843)CCG>CTG	p.P281L	FPGS_uc004bsh.1_Missense_Mutation_p.P98L|FPGS_uc011mal.1_Missense_Mutation_p.P255L|FPGS_uc004bsi.1_Missense_Mutation_p.P231L	NM_004957	NP_004948	Q05932	FOLC_HUMAN	folylpolyglutamate synthase isoform a precursor	281					folic acid metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|one-carbon metabolic process	cytosol|mitochondrial matrix	ATP binding|tetrahydrofolylpolyglutamate synthase activity				0					L-Glutamic Acid(DB00142)	TACCTGTGTCCGATGCTGGAG	0.692													0	0	0	0.013537	0	9	20										T	130570856	C	T	130570856	3	4	104	1	0	0	0	0	1	0	0	0	6036	652	23	2	880	2	FPGS	9	130570856	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	34356236	130570856	10642575	97	32051										
TOR1A	1861	broad.mit.edu	37	chr9	132584943	132584943	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtcactgttcagaccaccctCgtaaatattctctgcgatga	7	12	3	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:132584943C>T	uc004byl.2	-	2	438	c.361G>A	c.(361-363)GAG>AAG	p.E121K	TOR1A_uc004bym.2_RNA|TOR1A_uc004byn.2_Missense_Mutation_p.E121K	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	121					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				AGACCACCCTCGTAAATATTC	0.488													0	0	0	0.005524	0	39	150										T	132584943	C	T	132584943	3	4	104	1	0	0	0	0	1	0	0	0	16368	893	31	1	653	1	TOR1A	9	132584943	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	2014087	132584943	8628488	98	32052										
VAV2	7410	broad.mit.edu	37	chr9	136634579	136634579	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gggccctgagaagcaaagctGaggccctgaggactgagaaa	15	9	0	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr9:136634579G>A	uc004ces.2	-	28	2440	c.2394C>T	c.(2392-2394)CTC>CTT	p.L798L	VAV2_uc004cer.2_Intron	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	798					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		AAGCAAAGCTGAGGCCCTGAG	0.632													0	0	0	0.000602	0	5	24										A	136634579	G	A	136634579	2	1	104	1	0	0	0	0	0	0	0	1	17129	1277	45	1		1	VAV2	9	136634579	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	4049636	136634579	4578852	99	32053										
GTPBP4	23560	broad.mit.edu	37	chr10	1042070	1042070	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gctaaagattatgtgcgactGatgaagtatggcgactctct	11	7	1	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:1042070G>C	uc001ift.2	+	4	419	c.348G>C	c.(346-348)CTG>CTC	p.L116L	GTPBP4_uc010qac.1_5'UTR|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_5'UTR|GTPBP4_uc010qae.1_Silent_p.L69L	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	116					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		ATGTGCGACTGATGAAGTATG	0.413													0	0	0	0.004672	0	3	12										C	1042070	G	C	1042070	2	2	104	1	0	0	0	0	0	0	0	1	6882	1277	45	1		1	GTPBP4	10	1042070	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		1042070	134492677	100	32054										
TET1	80312	broad.mit.edu	37	chr10	70404903	70404903	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccataaaaacgctatgagctCtgttgctactgatatgagtt	8	8	1	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:70404903C>T	uc001jok.3	+	4	2922	c.2417C>T	c.(2416-2418)TCT>TTT	p.S806F		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	806					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						GCTATGAGCTCTGTTGCTACT	0.358													0	0	0	0.003755	0	29	79										T	70404903	C	T	70404903	3	4	104	1	0	0	0	0	1	0	0	0	15766	913	32	1	2427	1	TET1	10	70404903	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	69362833	70404903	65129844	101	32055										
KCNMA1	3778	broad.mit.edu	37	chr10	78669798	78669798	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gggctgcgtgaggtacagttCtgtatcagggtcatcatcat	13	8	5	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:78669798C>G	uc001jxn.2	-	25	3250	c.3073G>C	c.(3073-3075)GAA>CAA	p.E1025Q	KCNMA1_uc001jxj.2_Missense_Mutation_p.E971Q|KCNMA1_uc001jxk.1_Missense_Mutation_p.E643Q|KCNMA1_uc009xrt.1_Missense_Mutation_p.E816Q|KCNMA1_uc001jxl.1_Missense_Mutation_p.E650Q|KCNMA1_uc001jxo.2_Missense_Mutation_p.E1008Q|KCNMA1_uc001jxm.2_Missense_Mutation_p.E967Q|KCNMA1_uc001jxq.2_Missense_Mutation_p.E997Q	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1025	Calcium bowl.|Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AGGTACAGTTCTGTATCAGGG	0.473													0	0	0	0.003271	0	29	17										G	78669798	C	G	78669798	3	3	104	1	0	0	0	0	1	0	0	0	8073	922	32	1	682	1	KCNMA1	10	78669798	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	8264895	78669798	56864949	102	32056										
DLG5	9231	broad.mit.edu	37	chr10	79565534	79565534	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cctccgaaaaaaggaccggcGtgcagccgctgacagcgtct	12	14	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr10:79565534G>A	uc001jzk.2	-	27	5123	c.5053C>T	c.(5053-5055)CGC>TGC	p.R1685C	DLG5_uc001jzi.2_Missense_Mutation_p.R440C|DLG5_uc001jzj.2_Missense_Mutation_p.R1100C|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1685					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AAGGACCGGCGTGCAGCCGCT	0.552													0	0	0	0.01441	0	83	37										A	79565534	G	A	79565534	3	1	104	1	0	0	0	0	1	0	0	0	4558	1145	40	2	730	2	DLG5	10	79565534	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	895736	79565534	55969213	103	32057										
OR52E8	390079	broad.mit.edu	37	chr11	5878060	5878060	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccatagattacaggattgagGgctggtgggacaaccacata	12	8	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:5878060G>T	uc010qzr.1	-	1	873	c.873C>A	c.(871-873)GCC>GCA	p.A291A	TRIM5_uc001mbq.1_Intron	NM_001005168	NP_001005168	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGGATTGAGGGCTGGTGGGA	0.423													1	0	2.02624e-56	0.01441	2.25348e-56	85	145										T	5878060	G	T	5878060	2	4	104	1	0	0	0	0	0	0	0	1	11118	1219	43	4		4	OR52E8	11	5878060	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		5878060	129128456	104	32058										
NLRP14	338323	broad.mit.edu	37	chr11	7064578	7064578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gaatatggactatgacttacGtgttttacagagaaaatctc	8	6	1	2	rs147389856	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:7064578G>A	uc001mfb.1	+	4	1644	c.1321G>A	c.(1321-1323)GTG>ATG	p.V441M		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	441	NACHT.		V -> M.		cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TATGACTTACGTGTTTTACAG	0.438													0	0	0	0.01441	0	63	91										A	7064578	G	A	7064578	3	1	104	1	0	0	0	0	1	0	0	0	10476	1145	40	2	1331	2	NLRP14	11	7064578	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1186518	7064578	127941938	105	32059										
NAV2	89797	broad.mit.edu	37	chr11	19735319	19735319	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcgccgcgcccatcctgcaCgtgcccccggcccgggcggg	15	20	0	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:19735319C>T	uc010rdm.1	+	1	439	c.78C>T	c.(76-78)CAC>CAT	p.H26H	NAV2_uc001mpp.2_Intron|NAV2_uc001mpr.3_Silent_p.H26H|LOC100126784_uc010rdl.1_3'UTR	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	26						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCATCCTGCACGTgcccccgg	0.537													0	0	0	0.003954	0	20	16										T	19735319	C	T	19735319	2	4	104	1	0	0	0	0	0	0	0	1	10184	535	19	2		2	NAV2	11	19735319	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	12670741	19735319	115271197	106	32060										
LRP4	4038	broad.mit.edu	37	chr11	46916236	46916243	+	Frame_Shift_Del	DEL	CAAGCTCG	CAAGCTCG	-													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggtgacatctgaccagaagaCaagctcgcggcggtggtgga					rs141108617		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:46916236_46916243delCAAGCTCG	uc001ndn.3	-	12	1583_1590	c.1437_1444delCGAGCTTG	c.(1435-1446)CGCGAGCTTGTCfs	p.R479fs		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	479_482	Extracellular (Potential).|LDL-receptor class B 1.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GACCAGAAGACAAGCTCGCGGCGGTGGT	0.587																		11	51	---	---								-	46916243	CAAGCTCG	-	46916236	7	5	104	1	0	1	0	1	0	0	0	0	8959	478	17	0	4381	0	LRP4	11	46916236	Frame_Shift_Del	DEL	CAAGCTCG	TCGA-GC-A3RB-01A-12D-A21Z-08	27180917	46916236	88090280	107	32061										
ZFP91	80829	broad.mit.edu	37	chr11	58379117	58379117	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gaaaatcagggaaggtaaaaGaagagaaggagaagaaggaa	15	1	1	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:58379117G>C	uc001nmx.3	+	6	931	c.763G>C	c.(763-765)GAA>CAA	p.E255Q	ZFP91_uc001nmy.3_Missense_Mutation_p.E254Q|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	255	Glu-rich.				activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				gaaggtaaaagaagagaagga	0.209													0	0	0	0.003163	0	15	18										C	58379117	G	C	58379117	3	2	104	1	0	0	0	0	1	0	0	0	17652	943	33	1	785	1	ZFP91	11	58379117	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	11462881	58379117	76627399	108	32062										
STX3	6809	broad.mit.edu	37	chr11	59540702	59540702	+	Missense_Mutation	SNP	G	G	A													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agaagcagctgacacaggatGatgatactgatgcggttgag							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:59540702G>A	uc001nog.2	+	2	239	c.49G>A	c.(49-51)GAT>AAT	p.D17N	STX3_uc010rkx.1_Missense_Mutation_p.D17N|STX3_uc010rky.1_5'UTR	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	17	Cytoplasmic (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						GACACAGGATGATGATACTGA	0.348													0	0	0	0.01441	0	72	168										A	59540702	G	A	59540702	3	1	104	1	0	0	0	0	1	0	0	0	15345	1290	45	1	55	1	STX3	11	59540702	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1161585	59540702	75465814	109	32063	159	2								
STX3	6809	broad.mit.edu	37	chr11	59540705	59540705	+	Missense_Mutation	SNP	G	G	A													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcagctgacacaggatgatGatactgatgcggttgagatt							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:59540705G>A	uc001nog.2	+	2	242	c.52G>A	c.(52-54)GAT>AAT	p.D18N	STX3_uc010rkx.1_Missense_Mutation_p.D18N|STX3_uc010rky.1_5'UTR	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	18	Cytoplasmic (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						ACAGGATGATGATACTGATGC	0.348													0	0	0	0.01441	0	73	171										A	59540705	G	A	59540705	3	1	104	1	0	0	0	0	1	0	0	0	15345	1290	45	1	58	1	STX3	11	59540705	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	3	59540705	75465811	110	32064	159	2								
RCE1	9986	broad.mit.edu	37	chr11	66611253	66611253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccatcccgcggtcatcaagcGacgcttcaccagcgtcctgg	10	17	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:66611253G>A	uc001ojk.1	+	2	253	c.209G>A	c.(208-210)CGA>CAA	p.R70Q	RCE1_uc001ojl.1_5'UTR	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	70					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						GTCATCAAGCGACGCTTCACC	0.672													0	0	0	0.008871	0	18	40										A	66611253	G	A	66611253	3	1	104	1	0	0	0	0	1	0	0	0	13176	1058	37	1	215	1	RCE1	11	66611253	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	7070548	66611253	68395263	111	32065										
GRM5	2915	broad.mit.edu	37	chr11	88323888	88323888	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aacagctgacttctccctttCggatcacctaaggcaaatat	6	12	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:88323888C>T	uc001pcq.2	-	6	1771	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q	GRM5_uc009yvm.2_Missense_Mutation_p.R524Q	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	524	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TTCTCCCTTTCGGATCACCTA	0.378													0	0	0	0.003271	0	28	69										T	88323888	C	T	88323888	3	4	104	1	0	0	0	0	1	0	0	0	6800	884	31	1	2083	1	GRM5	11	88323888	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	21712635	88323888	46682628	112	32066										
EXPH5	23086	broad.mit.edu	37	chr11	108381102	108381102	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctttagaattctcatgctttGatggtgattctgagacgttt	9	6	2	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr11:108381102G>A	uc001pkk.2	-	6	5243	c.5132C>T	c.(5131-5133)TCA>TTA	p.S1711L	EXPH5_uc010rvy.1_Missense_Mutation_p.S1523L|EXPH5_uc010rvz.1_Missense_Mutation_p.S1555L|EXPH5_uc010rwa.1_Missense_Mutation_p.S1635L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1711					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTCATGCTTTGATGGTGATTC	0.443													0	0	0	0.004878	0	38	94										A	108381102	G	A	108381102	3	1	104	1	0	0	0	0	1	0	0	0	5322	1294	45	1	841	1	EXPH5	11	108381102	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	20057214	108381102	26625414	113	32067										
CACNA1C	775	broad.mit.edu	37	chr12	2760832	2760832	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gaggaaaactcccgcatctcCatcaccttcttccgcctgtt	6	16	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:2760832C>T	uc009zdu.1	+	34	4429	c.4116C>T	c.(4114-4116)TCC>TCT	p.S1372S	CACNA1C_uc009zdv.1_Silent_p.S1321S|CACNA1C_uc001qkb.2_Silent_p.S1324S|CACNA1C_uc001qkc.2_Silent_p.S1324S|CACNA1C_uc001qke.2_Silent_p.S1313S|CACNA1C_uc001qkf.2_Silent_p.S1313S|CACNA1C_uc001qjz.2_Silent_p.S1324S|CACNA1C_uc001qkd.2_Silent_p.S1324S|CACNA1C_uc001qkg.2_Silent_p.S1311S|CACNA1C_uc009zdw.1_Silent_p.S1346S|CACNA1C_uc001qkh.2_Silent_p.S1313S|CACNA1C_uc001qkl.2_Silent_p.S1372S|CACNA1C_uc001qkn.2_Silent_p.S1324S|CACNA1C_uc001qko.2_Silent_p.S1344S|CACNA1C_uc001qkp.2_Silent_p.S1324S|CACNA1C_uc001qkr.2_Silent_p.S1341S|CACNA1C_uc001qku.2_Silent_p.S1324S|CACNA1C_uc001qkq.2_Silent_p.S1352S|CACNA1C_uc001qks.2_Silent_p.S1324S|CACNA1C_uc001qkt.2_Silent_p.S1324S|CACNA1C_uc001qki.1_Silent_p.S1060S|CACNA1C_uc001qkj.1_Silent_p.S1060S|CACNA1C_uc001qkk.1_Silent_p.S1060S|CACNA1C_uc001qkm.1_Silent_p.S1049S|CACNA1C_uc010sea.1_Silent_p.S15S	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1372	Extracellular (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCCGCATCTCCATCACCTTCT	0.612													0	0	0	0.013726	0	28	136										T	2760832	C	T	2760832	2	4	104	1	0	0	0	0	0	0	0	1	2540	581	21	2		2	CACNA1C	12	2760832	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		2760832	131091063	114	32068										
ACSM4	341392	broad.mit.edu	37	chr12	7459281	7459281	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cagagaggagaccgtttggcCgtgattctgcccagaatccc	12	12	1	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:7459281C>T	uc001qsx.1	+	2	354	c.354C>T	c.(352-354)GCC>GCT	p.A118A		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	118					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						ACCGTTTGGCCGTGATTCTGC	0.512													0	0	0	0.012213	0	25	11										T	7459281	C	T	7459281	2	4	104	1	0	0	0	0	0	0	0	1	186	639	23	2		2	ACSM4	12	7459281	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4698449	7459281	126392614	115	32069										
CLEC4E	26253	broad.mit.edu	37	chr12	8691854	8691854	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agagctctgtgaaattctcaGgtagctgaaactttttctca	8	8	3	3	rs137962363		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:8691854G>A	uc001quo.1	-	3	344	c.179C>T	c.(178-180)CCT>CTT	p.P60L		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	60	Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					GAAATTCTCAGGTAGCTGAAA	0.358													0	0	0	0.008291	0	10	230										A	8691854	G	A	8691854	3	1	104	1	0	0	0	0	1	0	0	0	3515	1000	35	2	496	2	CLEC4E	12	8691854	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1232573	8691854	125160041	116	32070										
PLCZ1	89869	broad.mit.edu	37	chr12	18854476	18854476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tactccaggtaacttttttaCccctgtttccttgtcttgat	5	11	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:18854476C>T	uc010sid.1	-	9	1167	c.976G>A	c.(976-978)GTA>ATA	p.V326I	PLCZ1_uc001rdv.3_Missense_Mutation_p.V222I|PLCZ1_uc001rdw.3_Missense_Mutation_p.V67I|PLCZ1_uc001rdu.1_Missense_Mutation_p.V108I|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	326					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AACTTTTTTACCCCTGTTTCC	0.264													0	0	0	0.01441	0	46	32										T	18854476	C	T	18854476	3	4	104	1	0	0	0	0	1	0	0	0	12044	507	18	2	878	2	PLCZ1	12	18854476	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	10162622	18854476	114997419	117	32071										
PRKAG1	5571	broad.mit.edu	37	chr12	49406886	49406886	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cagctggggagctatctgaaGaaatgacctggagagataag	14	6	1	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:49406886G>C	uc001rsy.2	-	2	86	c.17C>G	c.(16-18)TCT>TGT	p.S6C	uc001rsw.2_Intron|PRKAG1_uc010smd.1_5'UTR|PRKAG1_uc001rsx.2_5'UTR|PRKAG1_uc001rsz.2_Missense_Mutation_p.S6C|PRKAG1_uc009zlb.2_5'UTR|PRKAG1_uc010sme.1_Missense_Mutation_p.S6C	NM_002733	NP_002724	P54619	AAKG1_HUMAN	AMP-activated protein kinase, noncatalytic	6					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1						GCTATCTGAAGAAATGACCTG	0.423													0	0	0	0.009718	0	38	23										C	49406886	G	C	49406886	3	2	104	1	0	0	0	0	1	0	0	0	12500	942	33	1	1022	1	PRKAG1	12	49406886	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	30552410	49406886	84445009	118	32072										
MLL2	8085	broad.mit.edu	37	chr12	49443634	49443634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctcgggctggactaacatccGtagagacccccaactccatg	9	15	0	1	rs112921115		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:49443634G>A	uc001rta.3	-	11	3737	c.3737C>T	c.(3736-3738)ACG>ATG	p.T1246M		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1246					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACTAACATCCGTAGAGACCCC	0.602			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.01441	0	97	80										A	49443634	G	A	49443634	3	1	104	1	0	0	0	0	1	0	0	0	9621	1145	40	2	13052	2	MLL2	12	49443634	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	36748	49443634	84408261	119	32073										
MLL2	8085	broad.mit.edu	37	chr12	49446856	49446856	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcccggcacacccggcacgcCtaagggaagggagtgggcaa	16	13	0	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:49446856C>T	uc001rta.3	-	8	955	c.955_splice	c.e8-1	p.A319_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCGGCACGCCTAAGGGAAGG	0.532			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.01441	0	47	111										T	49446856	C	T	49446856	5	4	104	1	0	0	0	0	0	0	1	0	9621	695	24	2	15847	2	MLL2	12	49446856	Splice_Site	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	3222	49446856	84405039	120	32074										
KRT18	3875	broad.mit.edu	37	chr12	53343177	53343177	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tagccgggggtctggcaggaAtgggaggcatccagaacgag	18	8	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:53343177A>T	uc001sbe.2	+	2	289	c.220A>T	c.(220-222)ATG>TTG	p.M74L	KRT18_uc009zmn.1_Missense_Mutation_p.M74L|KRT18_uc001sbf.1_5'UTR|KRT18_uc001sbg.2_Missense_Mutation_p.M74L|KRT18_uc009zmo.2_Missense_Mutation_p.M74L|KRT8_uc009zml.1_Intron|KRT8_uc009zmm.1_Intron	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	74	Head.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						TCTGGCAGGAATGGGAGGCAT	0.662													0	0	0	0.012213	0	30	55										T	53343177	A	T	53343177	3	4	104	1	0	0	0	0	1	0	0	0	8455	101	4	5	222	5	KRT18	12	53343177	Missense_Mutation	SNP	A	TCGA-GC-A3RB-01A-12D-A21Z-08	3896321	53343177	80508718	121	32075										
OR6C74	254783	broad.mit.edu	37	chr12	55641322	55641322	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	caaatttcttgttagtatggCaacaggtgataagaccattt	8	6	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:55641322C>A	uc010spg.1	+	1	251	c.251C>A	c.(250-252)GCA>GAA	p.A84E		NM_001005490	NP_001005490	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C,	84	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						GTTAGTATGGCAACAGGTGAT	0.398													1	0	1.61879e-10	0.013537	1.6751e-10	10	266										A	55641322	C	A	55641322	3	1	104	1	0	0	0	0	1	0	0	0	11198	710	25	4	253	4	OR6C74	12	55641322	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	2298145	55641322	78210573	122	32076										
NUDT4	11163	broad.mit.edu	37	chr12	93793095	93793095	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acagtcccttcccttccggaTaataatgccttgtttgtaac	6	12	0	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:93793095T>G	uc001tcm.2	+	5	881	c.483T>G	c.(481-483)GAT>GAG	p.D161E	NUDT4_uc010sup.1_Missense_Mutation_p.D161E|NUDT4_uc001tcn.2_Missense_Mutation_p.D109E|NUDT4_uc010suq.1_Missense_Mutation_p.D110E|NUDT4_uc001tco.2_Missense_Mutation_p.D109E	NM_019094	NP_061967	Q9NZJ9	NUDT4_HUMAN	nudix-type motif 4 isoform alpha	161					calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0						CCCTTCCGGATAATAATGCCT	0.478													0	0	0	0.008291	0	8	283										G	93793095	T	G	93793095	3	3	104	1	0	0	0	0	1	0	0	0	10741	1403	49	5	504	5	NUDT4	12	93793095	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	38151773	93793095	40058800	123	32077										
GOLGA2B	55592	broad.mit.edu	37	chr12	100551433	100551433	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aggccaacagatgagccaggCgctggcagtgcactccttca	12	13	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:100551433C>A	uc001tgs.2	-	4	607	c.163G>T	c.(163-165)GCC>TCC	p.A55S	GOLGA2B_uc001tgt.2_RNA|GOLGA2B_uc001tgu.2_Missense_Mutation_p.A55S|uc001tgx.2_5'Flank	NM_017600	NP_060070			golgi autoantigen, golgin subfamily a, 2-like 1												0						ATGAGCCAGGCGCTGGCAGTG	0.622													1	0	3.73148e-12	0.007291	3.87813e-12	22	47										A	100551433	C	A	100551433	3	1	104	1	0	0	0	0	1	0	0	0	6553	768	27	4	283	4	GOLGA2B	12	100551433	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	6758338	100551433	33300462	124	32078										
EID3	493861	broad.mit.edu	37	chr12	104697751	104697751	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtgagggccgcgggctgctcCgacgacctcagctctgggga	17	13	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:104697751C>T	uc001tkw.2	+	1	203	c.39C>T	c.(37-39)TCC>TCT	p.S13S	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0						CGGGCTGCTCCGACGACCTCA	0.662													0	0	0	0.000602	0	5	22										T	104697751	C	T	104697751	2	4	104	1	0	0	0	0	0	0	0	1	4989	639	23	2		2	EID3	12	104697751	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4146318	104697751	29154144	125	32079										
POLR3B	55703	broad.mit.edu	37	chr12	106890641	106890641	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aggatgtgtgtgaggacctcGttcgccatggttataactac	12	8	0	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:106890641G>A	uc001tlp.2	+	25	3151	c.2929G>A	c.(2929-2931)GTT>ATT	p.V977I	POLR3B_uc001tlq.2_Missense_Mutation_p.V919I	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	977					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TGAGGACCTCGTTCGCCATGG	0.488													0	0	0	0.01441	0	42	102										A	106890641	G	A	106890641	3	1	104	1	0	0	0	0	1	0	0	0	12229	1145	40	2	3027	2	POLR3B	12	106890641	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	2192890	106890641	26961254	126	32080										
GLTP	51228	broad.mit.edu	37	chr12	110318126	110318126	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tcgaggaagggcccggtctcGatctgcttgtccgcgggcag	16	12	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:110318126G>C	uc001tpm.2	-	1	168	c.54C>G	c.(52-54)ATC>ATG	p.I18M	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	18						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		GCCCGGTCTCGATCTGCTTGT	0.627													0	0	0	0.00499	0	12	24										C	110318126	G	C	110318126	3	2	104	1	0	0	0	0	1	0	0	0	6471	1048	37	1	595	1	GLTP	12	110318126	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	3427485	110318126	23533769	127	32081										
GIT2	9815	broad.mit.edu	37	chr12	110397701	110397701	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgtctcctcttggcgtcactGagaatgtcaatgaccagcgt	10	11	4	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:110397701G>C	uc001tps.2	-	12	1215	c.1050C>G	c.(1048-1050)CTC>CTG	p.L350L	GIT2_uc001tpq.2_Silent_p.L350L|GIT2_uc001tpv.2_Silent_p.L352L|GIT2_uc001tpu.2_Silent_p.L350L|GIT2_uc001tpt.2_Silent_p.L350L|GIT2_uc010sxu.1_Silent_p.L288L|GIT2_uc001tpw.2_Silent_p.L350L|GIT2_uc010sxv.1_Silent_p.L350L	NM_057169	NP_476510	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting	350					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1						TGGCGTCACTGAGAATGTCAA	0.463													0	0	0	0.005443	0	22	59										C	110397701	G	C	110397701	2	2	104	1	0	0	0	0	0	0	0	1	6397	1277	45	1		1	GIT2	12	110397701	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	79575	110397701	23454194	128	32082										
C12orf51	283450	broad.mit.edu	37	chr12	112696955	112696955	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agctgcactagctgaggcatCagggcatccgccatgatcag	12	12	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:112696955C>G	uc009zwc.2	-	12	1710	c.1692G>C	c.(1690-1692)CTG>CTC	p.L564L	C12orf51_uc010syk.1_Silent_p.L387L|C12orf51_uc001tts.2_Silent_p.L387L|C12orf51_uc001ttt.3_Silent_p.L385L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GCTGAGGCATCAGGGCATCCG	0.483													0	0	0	0.01441	0	41	694										G	112696955	C	G	112696955	2	3	104	1	0	0	0	0	0	0	0	1	1696	813	29	1		1	C12orf51	12	112696955	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	2299254	112696955	21154940	129	32083										
SFRS9	8683	broad.mit.edu	37	chr12	120901878	120901878	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ataacagacatccccagcttCtcgcatgtgatccttcaggt	7	13	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:120901878C>T	uc001tyi.2	-	3	543	c.397G>A	c.(397-399)GAA>AAA	p.E133K		NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9	133	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCCCAGCTTCTCGCATGTGA	0.507													0	0	0	0.01441	0	45	149										T	120901878	C	T	120901878	3	4	104	1	0	0	0	0	1	0	0	0	14184	922	32	1	276	1	SFRS9	12	120901878	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	8204923	120901878	12950017	130	32084										
VPS33A	65082	broad.mit.edu	37	chr12	122723263	122723263	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcgatacaatcctcaatgtaAttgttgacctggaaataaag	8	7	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:122723263A>G	uc001ucd.2	-	10	1286	c.1173T>C	c.(1171-1173)AAT>AAC	p.N391N	VPS33A_uc001ucc.2_RNA	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	391					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CCTCAATGTAATTGTTGACCT	0.259													0	0	0	0.01441	0	53	114										G	122723263	A	G	122723263	2	3	104	1	0	0	0	0	0	0	0	1	17198	98	4	5		5	VPS33A	12	122723263	Silent	SNP	A	TCGA-GC-A3RB-01A-12D-A21Z-08	1821385	122723263	11128632	131	32085										
RIMBP2	23504	broad.mit.edu	37	chr12	130926783	130926783	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggctgccatgttgagcttctCgatgagggctttagttctgc	13	9	2	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr12:130926783C>T	uc001uil.2	-	8	1227	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	RIMBP2_uc001uim.2_Missense_Mutation_p.E263K|RIMBP2_uc001uin.1_Missense_Mutation_p.E14K	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	355	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TTGAGCTTCTCGATGAGGGCT	0.612													0	0	0	0.006122	0	14	72										T	130926783	C	T	130926783	3	4	104	1	0	0	0	0	1	0	0	0	13363	893	31	1	2143	1	RIMBP2	12	130926783	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	8203520	130926783	2925112	132	32086										
OR4K2	390431	broad.mit.edu	37	chr14	20345191	20345191	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttgttctttgggccatgcatCttcatctacatgtggccact	8	11	4	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:20345191C>T	uc001vwh.1	+	1	765	c.765C>T	c.(763-765)ATC>ATT	p.I255I		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCCATGCATCTTCATCTACA	0.408													0	0	0	0.00278	0	21	92										T	20345191	C	T	20345191	2	4	104	1	0	0	0	0	0	0	0	1	11072	903	32	1		1	OR4K2	14	20345191	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		20345191	87004349	133	32087										
PROX2	283571	broad.mit.edu	37	chr14	75330507	75330507	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtgggagcagatctggggctGaggagaaagcaagatggagt	19	4	1	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:75330507G>A	uc001xqr.1	-	1	31	c.31C>T	c.(31-33)CAG>TAG	p.Q11*	PROX2_uc001xqq.1_5'UTR	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	11					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		ATCTGGGGCTGAGGAGAAAGC	0.542													0	0	0	0.007291	0	22	69										A	75330507	G	A	75330507	4	1	104	1	0	0	0	0	0	1	0	0	12561	1299	45	1	1763	1	PROX2	14	75330507	Nonsense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	54985316	75330507	32019033	134	32088										
C14orf179	112752	broad.mit.edu	37	chr14	76548711	76548711	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	caggtggcagcccctcccagGtaggttaaatcagatatgat	11	10	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:76548711G>A	uc010asm.1	+	6	402	c.368_splice	c.e6+1	p.S123_splice	C14orf179_uc001xsf.2_RNA|C14orf179_uc010asl.1_Silent_p.R123R|C14orf179_uc001xsg.2_Splice_Site_p.S128_splice|C14orf179_uc010tve.1_Splice_Site	NM_001102564	NP_001096034	Q96FT9	IFT43_HUMAN	hypothetical protein LOC112752 isoform 2						cilium morphogenesis|intraflagellar retrograde transport						0				BRCA - Breast invasive adenocarcinoma(234;0.0199)		CCCCTCCCAGGTAGGTTAAAT	0.453													0	0	0	0.01441	0	84	217										A	76548711	G	A	76548711	5	1	104	1	0	0	0	0	0	0	1	0	1762	1275	44	2	490	2	C14orf179	14	76548711	Splice_Site	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1218204	76548711	30800829	135	32089										
DICER1	23405	broad.mit.edu	37	chr14	95590756	95590756	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctcatatggtttatatttgcGtaagatttcgagcagtttga	9	5	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr14:95590756G>A	uc001ydw.2	-	9	1335	c.1153C>T	c.(1153-1155)CGC>TGC	p.R385C	DICER1_uc001ydv.2_Missense_Mutation_p.R375C|DICER1_uc001ydx.2_Missense_Mutation_p.R385C	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	385	Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TTATATTTGCGTAAGATTTCG	0.378			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.00874	0	39	56										A	95590756	G	A	95590756	3	1	104	1	0	0	0	0	1	0	0	0	4521	1145	40	2	4695	2	DICER1	14	95590756	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	19042045	95590756	11758784	136	32090										
AQR	9716	broad.mit.edu	37	chr15	35202345	35202345	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tacaaacttaccttcccattCatctttgatgtgatctctga	4	11	3	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:35202345C>T	uc001ziv.2	-	17	1835	c.1654G>A	c.(1654-1656)GAA>AAA	p.E552K		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	552						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		CCTTCCCATTCATCTTTGATG	0.368													0	0	0	0.01441	0	45	104										T	35202345	C	T	35202345	3	4	104	1	0	0	0	0	1	0	0	0	835	835	29	1	2879	1	AQR	15	35202345	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		35202345	67329047	137	32091										
KIAA0101	9768	broad.mit.edu	37	chr15	64669028	64669028	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tctttaggggacaacctaaaGaattctccaattcctttttg	6	9	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:64669028G>C	uc002ank.2	-	3	336	c.204C>G	c.(202-204)TTC>TTG	p.F68L	KIAA0101_uc002anl.2_Intron	NM_014736	NP_055551	Q15004	PAF_HUMAN	hypothetical protein LOC9768 isoform 1	68				F->A: Loss of binding to PCNA.		mitochondrion|nucleus				central_nervous_system(1)	1						ACAACCTAAAGAATTCTCCAA	0.403													0	0	0	0.013726	0	32	21										C	64669028	G	C	64669028	3	2	104	1	0	0	0	0	1	0	0	0	8155	933	33	1	164	1	KIAA0101	15	64669028	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	29466683	64669028	37862364	138	32092										
STARD5	80765	broad.mit.edu	37	chr15	81605711	81605711	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	taaccgctgaggtcggtatgGaagaatgtgaccaggttggt	15	6	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:81605711G>T	uc002bgm.2	-	6	612	c.528C>A	c.(526-528)TTC>TTA	p.F176L	STARD5_uc002bgn.2_Missense_Mutation_p.F69L	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	176	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						GGTCGGTATGGAAGAATGTGA	0.567													1	0	1.67211e-32	0.01441	1.84242e-32	42	96										T	81605711	G	T	81605711	3	4	104	1	0	0	0	0	1	0	0	0	15259	1165	41	3	117	3	STARD5	15	81605711	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	16936683	81605711	20925681	139	32093										
AEN	64782	broad.mit.edu	37	chr15	89169733	89169733	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cccatgcagcagaaggcctgCtcccgggaaagcctcagggc	13	15	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr15:89169733C>T	uc002bmt.2	+	2	444	c.293C>T	c.(292-294)GCT>GTT	p.A98V	AEN_uc010bnl.2_Missense_Mutation_p.A98V|AEN_uc010bnm.1_Missense_Mutation_p.A98V	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	98					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						AGAAGGCCTGCTCCCGGGAAA	0.662													0	0	0	0.006122	0	16	47										T	89169733	C	T	89169733	3	4	104	1	0	0	0	0	1	0	0	0	351	797	28	2	295	2	AEN	15	89169733	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	7564022	89169733	13361659	140	32094										
NOXO1	124056	broad.mit.edu	37	chr16	2029284	2029284	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccacggaaccccgtcccgctCaggagagcgcccagcccttc	10	20	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:2029284C>G	uc002cnx.2	-	8	904	c.900G>C	c.(898-900)CTG>CTC	p.L300L	NOXO1_uc002cnz.2_Silent_p.L294L|NOXO1_uc002coa.2_Silent_p.L299L|NOXO1_uc002cny.2_Silent_p.L295L	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	300					cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						CCGTCCCGCTCAGGAGAGCGC	0.776													0	0	0	0.000602	0	3	2										G	2029284	C	G	2029284	2	3	104	1	0	0	0	0	0	0	0	1	10561	813	29	1		1	NOXO1	16	2029284	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		2029284	88325469	141	32095										
NOXO1	124056	broad.mit.edu	37	chr16	2029448	2029448	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcatagccaccagccgcggtCtgacgtttccaacacgcgca	10	16	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:2029448C>G	uc002cnx.2	-	7	815	c.811G>C	c.(811-813)GAC>CAC	p.D271H	NOXO1_uc002cnz.2_Missense_Mutation_p.D265H|NOXO1_uc002coa.2_Missense_Mutation_p.D270H|NOXO1_uc002cny.2_Missense_Mutation_p.D266H	NM_172168	NP_751908	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1 isoform c	271	SH3 2.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity				0						CAGCCGCGGTCTGACGTTTCC	0.721													0	0	0	0.004672	0	3	14										G	2029448	C	G	2029448	3	3	104	1	0	0	0	0	1	0	0	0	10561	913	32	1	327	1	NOXO1	16	2029448	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	164	2029448	88325305	142	32096										
ZNF19	7567	broad.mit.edu	37	chr16	71509173	71509173	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gctcaaggtgacctagctggGaagaagtcccaaaggccttc	12	11	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:71509173G>T	uc010cgc.1	-	6	1783	c.1277C>A	c.(1276-1278)TCC>TAC	p.S426Y	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.S414Y|ZNF19_uc002fal.1_Missense_Mutation_p.S414Y|ZNF19_uc002fam.1_Missense_Mutation_p.S426Y	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	426	C2H2-type 10; atypical.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		ACCTAGCTGGGAAGAAGTCCC	0.328													1	0	0.00448238	0.004482	0.00457857	9	31										T	71509173	G	T	71509173	3	4	104	1	0	0	0	0	1	0	0	0	17752	1174	41	3	103	3	ZNF19	16	71509173	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	69479725	71509173	18845580	143	32097										
DHX38	9785	broad.mit.edu	37	chr16	72138398	72138398	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctctcaggtagtggctcggcGctcagacctgaagctcatcg	12	13	3	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:72138398G>A	uc002fcb.2	+	15	2379	c.2024G>A	c.(2023-2025)CGC>CAC	p.R675H	DHX38_uc010vmp.1_Intron	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	675	Helicase ATP-binding.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				GTGGCTCGGCGCTCAGACCTG	0.612													0	0	0	0.008291	0	8	28										A	72138398	G	A	72138398	3	1	104	1	0	0	0	0	1	0	0	0	4511	1087	38	2	2078	2	DHX38	16	72138398	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	629225	72138398	18216355	144	32098										
PLCG2	5336	broad.mit.edu	37	chr16	81914556	81914556	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gattcgtccgtgttcatcctGgggtgaggcagctcttgtgt	14	9	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr16:81914556G>A	uc002fgt.2	+	8	842	c.690G>A	c.(688-690)CTG>CTA	p.L230L	PLCG2_uc010chg.1_Silent_p.L230L	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	230					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TGTTCATCCTGGGGTGAGGCA	0.537													0	0	0	0.01441	0	68	102										A	81914556	G	A	81914556	2	1	104	1	0	0	0	0	0	0	0	1	12036	1335	47	2		2	PLCG2	16	81914556	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	9776158	81914556	8440197	145	32099										
SMTNL2	342527	broad.mit.edu	37	chr17	4497118	4497118	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctccctctctcttccacagaGaagaattcctctttcacgtg	5	15	4	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:4497118G>C	uc002fyf.1	+	4	799	c.732G>C	c.(730-732)GAG>GAC	p.E244D	SMTNL2_uc002fye.2_Missense_Mutation_p.E100D	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	244											0				READ - Rectum adenocarcinoma(115;0.0325)		CTTCCACAGAGAAGAATTCCT	0.577													0	0	0	0.013537	0	10	71										C	4497118	G	C	4497118	3	2	104	1	0	0	0	0	1	0	0	0	14816	956	33	1	746	1	SMTNL2	17	4497118	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		4497118	76698092	146	32100										
TP53	7157	broad.mit.edu	37	chr17	7579413	7579414	+	Frame_Shift_Ins	INS	-	-	C													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gggacagaagatgacaggggINSccaggagggggctggtgcag							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:7579413_7579414insC	uc002gim.2	-	4	467_468	c.273_274insG	c.(271-276)TGGCCCfs	p.W91fs	TP53_uc002gig.1_Frame_Shift_Ins_p.W91fs|TP53_uc002gih.2_Frame_Shift_Ins_p.W91fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.W91fs|TP53_uc010cni.1_Frame_Shift_Ins_p.W91fs|TP53_uc002gij.2_Frame_Shift_Ins_p.W91fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.W52fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.W106fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	91_92	Interaction with WWOX.		P -> S (in a sporadic cancer; somatic mutation).|P -> A (in a sporadic cancer; somatic mutation).|P -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W91*(11)|p.0?(7)|p.G59fs*23(3)|p.V73fs*9(1)|p.D48fs*55(1)|p.L93fs*30(1)|p.P92fs*57(1)|p.W91fs*57(1)|p.A88fs*52(1)|p.P92A(1)|p.W91fs*13(1)|p.P87fs*54(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGACAGGGGCCAGGAGGGGG	0.629		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)								97	16	---	---								C	7579414	-	C	7579413	7	5	104	1	0	1	1	0	0	0	0	0	16378	1203	42	0	1028	0	TP53	17	7579413	Frame_Shift_Ins	INS	-	TCGA-GC-A3RB-01A-12D-A21Z-08	3082295	7579413	73615797	147	32101										
SLC47A1	55244	broad.mit.edu	37	chr17	19451306	19451306	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgtgcaccccagacgtacggGagccagaacctgaagcacgt	12	13	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:19451306G>C	uc002gvy.1	+	4	401	c.315G>C	c.(313-315)GGG>GGC	p.G105G	SLC47A1_uc010vyy.1_RNA|SLC47A1_uc002gvx.2_Silent_p.G105G|SLC47A1_uc010vyz.1_Silent_p.G82G|SLC47A1_uc010cqp.1_Silent_p.G105G|SLC47A1_uc010cqq.1_5'UTR	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	105	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AGACGTACGGGAGCCAGAACC	0.592													0	0	0	0.00278	0	23	37										C	19451306	G	C	19451306	2	2	104	1	0	0	0	0	0	0	0	1	14647	1161	41	1		1	SLC47A1	17	19451306	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	11871893	19451306	61743904	148	32102										
LGALS9	3965	broad.mit.edu	37	chr17	25967775	25967775	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	atgccctttgacctctgcttCctggtgcagagctcagattt	9	12	2	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:25967775C>T	uc002gzp.2	+	3	427	c.309C>T	c.(307-309)TTC>TTT	p.F103F	LGALS9_uc002gzq.2_Silent_p.F103F|LGALS9_uc002gzr.2_Silent_p.F46F|LGALS9_uc010waa.1_Silent_p.F46F|LGALS9_uc002gzs.2_Silent_p.F103F	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	103	Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		ACCTCTGCTTCCTGGTGCAGA	0.572													0	0	0	0.009535	0	30	57										T	25967775	C	T	25967775	2	4	104	1	0	0	0	0	0	0	0	1	8748	854	30	1		1	LGALS9	17	25967775	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	6516469	25967775	55227435	149	32103										
PHF12	57649	broad.mit.edu	37	chr17	27237353	27237353	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctctgcaaggccagaaacttGatcagcttctcgtccagcat	8	13	3	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:27237353G>A	uc002hdg.1	-	11	2780	c.2250C>T	c.(2248-2250)ATC>ATT	p.I750I	PHF12_uc010wbb.1_Silent_p.I732I|PHF12_uc002hdi.1_Silent_p.I746I|PHF12_uc002hdh.1_Silent_p.I533I	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	750					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CCAGAAACTTGATCAGCTTCT	0.493													0	0	0	0.01441	0	103	5										A	27237353	G	A	27237353	2	1	104	1	0	0	0	0	0	0	0	1	11823	1280	45	1		1	PHF12	17	27237353	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1269578	27237353	53957857	150	32104										
PHF12	57649	broad.mit.edu	37	chr17	27254016	27254016	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcagcattattacctttcggCgaacagtgcaccggtgacac	10	12	0	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:27254016C>T	uc002hdg.1	-	3	844	c.314G>A	c.(313-315)CGC>CAC	p.R105H	PHF12_uc010wbb.1_Missense_Mutation_p.R87H|PHF12_uc002hdi.1_Missense_Mutation_p.R101H|PHF12_uc002hdj.1_Missense_Mutation_p.R105H|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdk.1_Missense_Mutation_p.R101H|uc002hdl.2_Intron|PHF12_uc002hdh.1_5'Flank	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	105	PHD-type 1.|Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TACCTTTCGGCGAACAGTGCA	0.493													0	0	0	0.005443	0	23	125										T	27254016	C	T	27254016	3	4	104	1	0	0	0	0	1	0	0	0	11823	768	27	2	2778	2	PHF12	17	27254016	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	16663	27254016	53941194	151	32105										
CPD	1362	broad.mit.edu	37	chr17	28776730	28776730	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttggctctggcagaatttctCtgcctgaactacaaaaagaa	8	9	2	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:28776730C>T	uc002hfb.1	+	13	3048	c.3033C>T	c.(3031-3033)CTC>CTT	p.L1011L	CPD_uc010wbo.1_Silent_p.L764L|CPD_uc010wbp.1_Intron	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1011	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CAGAATTTCTCTGCCTGAACT	0.428													0	0	0	0.01441	0	124	93										T	28776730	C	T	28776730	2	4	104	1	0	0	0	0	0	0	0	1	3798	900	32	1		1	CPD	17	28776730	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	1522714	28776730	52418480	152	32106										
ACACA	31	broad.mit.edu	37	chr17	35506883	35506883	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaggtaagccccaatcccaaTggcccggcacgtcaccttag	9	15	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:35506883T>C	uc002hnm.2	-	45	5664	c.5473A>G	c.(5473-5475)ATT>GTT	p.I1825V	ACACA_uc002hnk.2_Missense_Mutation_p.I1747V|ACACA_uc002hnl.2_Missense_Mutation_p.I1767V|ACACA_uc002hnn.2_Missense_Mutation_p.I1825V|ACACA_uc002hno.2_Missense_Mutation_p.I1862V|ACACA_uc010cuy.2_Missense_Mutation_p.I470V|ACACA_uc010wdc.1_5'UTR	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1825	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CCAATCCCAATGGCCCGGCAC	0.428													0	0	0	0.003954	0	26	62										C	35506883	T	C	35506883	3	2	104	1	0	0	0	0	1	0	0	0	106	1464	51	5	1615	5	ACACA	17	35506883	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	6730153	35506883	45688327	153	32107										
KRT35	3886	broad.mit.edu	37	chr17	39635732	39635732	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgtctgactccaccagctgcCgcagggacacctccgtctca	9	17	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:39635732C>G	uc002hws.2	-	3	621	c.578G>C	c.(577-579)CGG>CCG	p.R193P		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	193	Rod.|Coil 1B.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				CACCAGCTGCCGCAGGGACAC	0.587													0	0	0	0.01441	0	79	76										G	39635732	C	G	39635732	3	3	104	1	0	0	0	0	1	0	0	0	8472	652	23	4	809	4	KRT35	17	39635732	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4128849	39635732	41559478	154	32108										
KIAA1267	284058	broad.mit.edu	37	chr17	44144914	44144914	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agtagaagagctaaaacttaCgtgttaataactccattgac	7	7	0	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:44144914C>A	uc002ikb.2	-	4	1737	c.1652_splice	c.e4+1	p.T551_splice	KIAA1267_uc002ikc.2_Splice_Site_p.T551_splice|KIAA1267_uc002ikd.2_Splice_Site_p.T551_splice|KIAA1267_uc010dav.2_Splice_Site_p.T551_splice	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058							MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTAAAACTTACGTGTTAATAA	0.413													1	0	6.17242e-35	0.01441	6.83272e-35	43	48										A	44144914	C	A	44144914	5	1	104	1	0	0	0	0	0	0	1	0	8219	550	19	4	1708	4	KIAA1267	17	44144914	Splice_Site	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4509182	44144914	37050296	155	32109										
RSAD1	55316	broad.mit.edu	37	chr17	48561095	48561095	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aagttttggccctggggctaCgcaccgatgtggggatcact	14	10	1	0	rs148371199		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:48561095C>T	uc002iqw.1	+	7	1137	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C	RSAD1_uc010wmq.1_Intron	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	361					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCTGGGGCTACGCACCGATGT	0.537													0	0	0	0.003163	0	12	53										T	48561095	C	T	48561095	3	4	104	1	0	0	0	0	1	0	0	0	13694	536	19	2	1107	2	RSAD1	17	48561095	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4416181	48561095	32634115	156	32110										
MKS1	54903	broad.mit.edu	37	chr17	56283666	56283666	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agcacattgtgaatggaactCtgctggctgaacccttccag	10	11	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:56283666C>G	uc002ivr.1	-	17	1641	c.1566G>C	c.(1564-1566)CAG>CAC	p.Q522H	MKS1_uc010wnq.1_Missense_Mutation_p.Q319H|MKS1_uc002ivs.1_Missense_Mutation_p.R450T	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	522					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						GAATGGAACTCTGCTGGCTGA	0.562													0	0	0	0.01441	0	52	170										G	56283666	C	G	56283666	3	3	104	1	0	0	0	0	1	0	0	0	9609	912	32	1	121	1	MKS1	17	56283666	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	7722571	56283666	24911544	157	32111										
TBX2	6909	broad.mit.edu	37	chr17	59480480	59480480	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ccacatagtgcgagccaacgAcatcctgaagctgccttaca	8	14	0	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:59480480A>G	uc010wox.1	+	3	1003	c.722A>G	c.(721-723)GAC>GGC	p.D241G	TBX2_uc002ize.2_Missense_Mutation_p.D231G|TBX2_uc002izg.2_Missense_Mutation_p.D87G	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	241	T-box.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						CGAGCCAACGACATCCTGAAG	0.632													0	0	0	0.003755	0	32	80										G	59480480	A	G	59480480	3	3	104	1	0	0	0	0	1	0	0	0	15652	275	10	5	732	5	TBX2	17	59480480	Missense_Mutation	SNP	A	TCGA-GC-A3RB-01A-12D-A21Z-08	3196814	59480480	21714730	158	32112										
STRADA	92335	broad.mit.edu	37	chr17	61787907	61787907	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gccttcagcaccccctgcagGatgtaagcaatcgccagctc	9	16	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:61787907G>A	uc002jbm.2	-	8	684	c.525C>T	c.(523-525)ATC>ATT	p.I175I	STRADA_uc002jbn.2_Silent_p.I117I|STRADA_uc002jbo.2_Silent_p.I138I|STRADA_uc002jbp.2_Silent_p.I138I|STRADA_uc002jbq.2_Silent_p.I117I|STRADA_uc010wpq.1_Silent_p.I131I|STRADA_uc010wpr.1_Silent_p.I146I|STRADA_uc010ddw.2_Silent_p.I146I|STRADA_uc002jbr.2_Silent_p.I117I	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	175	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1						CCCCCTGCAGGATGTAAGCAA	0.502													0	0	0	0.006122	0	15	43										A	61787907	G	A	61787907	2	1	104	1	0	0	0	0	0	0	0	1	15323	1164	41	1		1	STRADA	17	61787907	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	2307427	61787907	19407303	159	32113										
BPTF	2186	broad.mit.edu	37	chr17	65942274	65942274	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaagcagtgctgtgcagactCaccagattcagaatgtggtt	11	8	2	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:65942274C>T	uc002jgf.2	+	21	7511	c.7450C>T	c.(7450-7452)CAC>TAC	p.H2484Y	BPTF_uc002jge.2_Intron|BPTF_uc002jgg.2_Intron|BPTF_uc002jgh.2_5'Flank	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2610					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTGCAGACTCACCAGATTCA	0.493													0	0	0	0.014323	0	19	64										T	65942274	C	T	65942274	3	4	104	1	0	0	0	0	1	0	0	0	1495	826	29	1	7918	1	BPTF	17	65942274	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4154367	65942274	15252936	160	32114										
SRP68	6730	broad.mit.edu	37	chr17	74037019	74037019	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cctgcagggagcacttctctGaccgcacttgagtgatgagc	12	12	1	4			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr17:74037019G>A	uc002jqk.1	-	14	1600	c.1565C>T	c.(1564-1566)TCA>TTA	p.S522L	SRP68_uc010wsu.1_Missense_Mutation_p.S421L|SRP68_uc002jql.1_Missense_Mutation_p.S484L|SRP68_uc002jqj.1_Missense_Mutation_p.S183L	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	522					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						GCACTTCTCTGACCGCACTTG	0.582													0	0	0	0.01441	0	68	80										A	74037019	G	A	74037019	3	1	104	1	0	0	0	0	1	0	0	0	15155	1294	45	1	330	1	SRP68	17	74037019	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	8094745	74037019	7158191	161	32115										
MC5R	4161	broad.mit.edu	37	chr18	13826367	13826367	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ttcgctatgctgttcctcctGgtgtctctgtacatacacat	7	12	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr18:13826367G>A	uc010xaf.1	+	1	603	c.603G>A	c.(601-603)CTG>CTA	p.L201L		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	201	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGTTCCTCCTGGTGTCTCTGT	0.587													0	0	0	0.01441	0	174	519										A	13826367	G	A	13826367	2	1	104	1	0	0	0	0	0	0	0	1	9367	1335	47	2		2	MC5R	18	13826367	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		13826367	64250881	162	32116										
OSBPL1A	114876	broad.mit.edu	37	chr18	21948276	21948276	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acagatcctggaccacttgtCtgtgtccaaaatagcatgcc	8	12	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr18:21948276C>A	uc002kve.2	-	3	356	c.182G>T	c.(181-183)AGA>ATA	p.R61I		NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	61	ANK 1.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					GACCACTTGTCTGTGTCCAAA	0.318													1	0	2.14674e-31	0.01441	2.34369e-31	38	77										A	21948276	C	A	21948276	3	1	104	1	0	0	0	0	1	0	0	0	11277	913	32	3	2774	3	OSBPL1A	18	21948276	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	8121909	21948276	56128972	163	32117										
FECH	2235	broad.mit.edu	37	chr18	55221549	55221549	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tcatacagcgtttcaatatgGtcactggtaaatgctatcgg	9	8	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr18:55221549G>T	uc002lgq.3	-	9	1137	c.1020C>A	c.(1018-1020)GAC>GAA	p.D340E	FECH_uc002lgp.3_Missense_Mutation_p.D346E|FECH_uc002lgr.3_Missense_Mutation_p.D198E	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	340					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)				TTTCAATATGGTCACTGGTAA	0.453													1	0	2.61193e-14	0.009535	2.7385e-14	31	180										T	55221549	G	T	55221549	3	4	104	1	0	0	0	0	1	0	0	0	5808	1252	44	4	263	4	FECH	18	55221549	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	33273273	55221549	22855699	164	32118										
MED16	10025	broad.mit.edu	37	chr19	886012	886012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggcgatgtcggccagggccaCgcggccgcgcagccggcaca	17	16	0	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:886012C>T	uc002lqd.1	-	5	788	c.637G>A	c.(637-639)GTG>ATG	p.V213M	MED16_uc010drw.1_Missense_Mutation_p.V38M|MED16_uc002lqe.2_Missense_Mutation_p.V202M|MED16_uc002lqf.2_Missense_Mutation_p.V202M|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.V202M|MED16_uc010xfx.1_Intron|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	213	WD 2.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGGCCACGCGGCCGCGC	0.716													0	0	0	0.004672	0	3	18										T	886012	C	T	886012	3	4	104	1	0	0	0	0	1	0	0	0	9434	536	19	2	2044	2	MED16	19	886012	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		886012	58242971	165	32119										
DOT1L	84444	broad.mit.edu	37	chr19	2191089	2191089	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gccatatcctgcagcaggtcTacaaccactcggtgaccgac	9	15	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:2191089T>A	uc002lvb.3	+	5	379	c.343T>A	c.(343-345)TAC>AAC	p.Y115N		NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	115						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCAGGTCTACAACCACTC	0.642													0	0	0	0.013537	0	13	10										A	2191089	T	A	2191089	3	1	104	1	0	0	0	0	1	0	0	0	4709	1522	53	5	361	5	DOT1L	19	2191089	Missense_Mutation	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	1305077	2191089	56937894	166	32120										
SAFB2	9667	broad.mit.edu	37	chr19	5600272	5600272	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	cttccttcttaattacagttCtatttaaagacatggttatc	4	8	2	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:5600272C>G	uc002mcd.2	-	12	1772	c.1560_splice	c.e12-1	p.K520_splice		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		AATTACAGTTCTATTTAAAGA	0.413													0	0	0	0.000602	0	4	19										G	5600272	C	G	5600272	5	3	104	1	0	0	0	0	0	0	1	0	13807	927	32	1	1342	1	SAFB2	19	5600272	Splice_Site	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	3409183	5600272	53528711	167	32121										
CCDC151	115948	broad.mit.edu	37	chr19	11537068	11537068	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctctcgaaccaaggtctcctCtaggtactgcagctggttct	9	13	4	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:11537068C>G	uc002mrs.2	-	7	1002	c.859G>C	c.(859-861)GAG>CAG	p.E287Q	CCDC151_uc002mrr.2_Missense_Mutation_p.E222Q|CCDC151_uc010dxz.2_Missense_Mutation_p.E227Q	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	287	Potential.									ovary(1)	1						AAGGTCTCCTCTAGGTACTGC	0.622													0	0	0	0.006214	0	8	33										G	11537068	C	G	11537068	3	3	104	1	0	0	0	0	1	0	0	0	2786	922	32	1	956	1	CCDC151	19	11537068	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	5936796	11537068	47591915	168	32122										
C19orf56	51398	broad.mit.edu	37	chr19	12779345	12779345	+	Missense_Mutation	SNP	C	C	T													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aagtctcacatgaagctactCatcatttgcttcgtgtcctc							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:12779345C>T	uc002mud.2	-	3	491	c.243G>A	c.(241-243)ATG>ATA	p.M81I	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	81	Helical; (Potential).					integral to membrane					0						TGAAGCTACTCATCATTTGCT	0.537													0	0	0	0.00278	0	19	33										T	12779345	C	T	12779345	3	4	104	1	0	0	0	0	1	0	0	0	1938	826	29	1	85	1	C19orf56	19	12779345	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	1242277	12779345	46349638	169	32123	160	2								
C19orf56	51398	broad.mit.edu	37	chr19	12779348	12779348	+	Missense_Mutation	SNP	C	C	T													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tctcacatgaagctactcatCatttgcttcgtgtcctccga							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:12779348C>T	uc002mud.2	-	3	488	c.240G>A	c.(238-240)ATG>ATA	p.M80I	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	80	Helical; (Potential).					integral to membrane					0						AGCTACTCATCATTTGCTTCG	0.542													0	0	0	0.00333	0	19	34										T	12779348	C	T	12779348	3	4	104	1	0	0	0	0	1	0	0	0	1938	826	29	1	88	1	C19orf56	19	12779348	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	3	12779348	46349635	170	32124	160	2								
C19orf56	51398	broad.mit.edu	37	chr19	12779429	12779429	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcgacccaagcacaccacttCagctagggaaaggtaagtgg	12	11	1	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:12779429C>T	uc002mud.2	-	3	407	c.159G>A	c.(157-159)CTG>CTA	p.L53L	MAN2B1_uc002mub.2_5'Flank|MAN2B1_uc010dyv.1_5'Flank|WDR83_uc002mue.3_5'UTR|WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_5'Flank	NM_016145	NP_057229	Q9Y284	CS056_HUMAN	hypothetical protein LOC51398	53	Helical; (Potential).					integral to membrane					0						CACACCACTTCAGCTAGGGAA	0.522													0	0	0	0.007413	0	15	37										T	12779429	C	T	12779429	2	4	104	1	0	0	0	0	0	0	0	1	1938	813	29	1		1	C19orf56	19	12779429	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	81	12779429	46349554	171	32125										
IL27RA	9466	broad.mit.edu	37	chr19	14150702	14150702	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agttccactaccgaagatgtCaggaggcggcctggaccctg	13	12	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:14150702C>T	uc002mxx.2	+	4	937	c.514C>T	c.(514-516)CAG>TAG	p.Q172*		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	172	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						CCGAAGATGTCAGGAGGCGGC	0.587													0	0	0	0.013114	0	34	230										T	14150702	C	T	14150702	4	4	104	1	0	0	0	0	0	1	0	0	7681	827	29	1	528	1	IL27RA	19	14150702	Nonsense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	1371273	14150702	44978281	172	32126										
SLC25A42	284439	broad.mit.edu	37	chr19	19216402	19216402	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gtcctctactacacctacctCaacgagggatttctcagctt	6	14	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:19216402C>T	uc002nlf.1	+	5	397	c.246C>T	c.(244-246)CTC>CTT	p.L82L	SLC25A42_uc010xqn.1_Silent_p.L134L	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	82	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			ACACCTACCTCAACGAGGGAT	0.627													0	0	0	0.012319	0	18	37										T	19216402	C	T	19216402	2	4	104	1	0	0	0	0	0	0	0	1	14507	813	29	1		1	SLC25A42	19	19216402	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	5065700	19216402	39912581	173	32127										
SLC25A42	284439	broad.mit.edu	37	chr19	19217162	19217162	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acctaccccctggacctggtCagagcgcggatggccgtaac	12	15	1	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:19217162C>T	uc002nlf.1	+	6	616	c.465C>T	c.(463-465)GTC>GTT	p.V155V	SLC25A42_uc010xqn.1_Silent_p.V207V	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	155	Helical; Name=3; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TGGACCTGGTCAGAGCGCGGA	0.662													0	0	0	0.003954	0	25	62										T	19217162	C	T	19217162	2	4	104	1	0	0	0	0	0	0	0	1	14507	813	29	1		1	SLC25A42	19	19217162	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	760	19217162	39911821	174	32128										
PLAUR	5329	broad.mit.edu	37	chr19	44169569	44169569	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gggtcctgttggtcttctctGagtgggtacagcttttctcc	12	10	3	1			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:44169569G>T	uc002oxf.1	-	3	439	c.209C>A	c.(208-210)TCA>TAA	p.S70*	PLAUR_uc002oxd.1_Nonsense_Mutation_p.S70*|PLAUR_uc002oxe.1_Nonsense_Mutation_p.S65*|PLAUR_uc002oxg.1_Nonsense_Mutation_p.S70*	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	70	UPAR/Ly6 1.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	GGTCTTCTCTGAGTGGGTACA	0.542													1	0	1.8453e-21	0.010771	1.96942e-21	33	61										T	44169569	G	T	44169569	4	4	104	1	0	0	0	0	0	1	0	0	12023	1294	45	3	914	3	PLAUR	19	44169569	Nonsense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	24952407	44169569	14959414	175	32129										
ZNF226	7769	broad.mit.edu	37	chr19	44681738	44681738	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	caaatcttacagttcatcacAgaatccatgttggtgataaa	6	8	3	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:44681738A>G	uc002oyp.2	+	6	2467	c.2323A>G	c.(2323-2325)AGA>GGA	p.R775G	ZNF226_uc002oyq.2_Missense_Mutation_p.R658G|ZNF226_uc002oyr.2_Missense_Mutation_p.R658G|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.R775G|ZNF226_uc002oyt.2_Missense_Mutation_p.R775G	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	775	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTTCATCACAGAATCCATGT	0.368													0	0	0	0.000602	0	5	56										G	44681738	A	G	44681738	3	3	104	1	0	0	0	0	1	0	0	0	17777	180	7	5	2391	5	ZNF226	19	44681738	Missense_Mutation	SNP	A	TCGA-GC-A3RB-01A-12D-A21Z-08	512169	44681738	14447245	176	32130										
HSD17B14	51171	broad.mit.edu	37	chr19	49334931	49334931	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tcgccagccctcaccttggtCaaggtgtacgtccccagtag	10	15	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:49334931C>T	uc002pkv.1	-	5	629	c.363G>A	c.(361-363)TTG>TTA	p.L121L	HSD17B14_uc010emk.1_Silent_p.L121L	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	121					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		TCACCTTGGTCAAGGTGTACG	0.587													0	0	0	0.006999	0	36	95										T	49334931	C	T	49334931	2	4	104	1	0	0	0	0	0	0	0	1	7383	825	29	1		1	HSD17B14	19	49334931	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	4653193	49334931	9794052	177	32131										
ZNF615	284370	broad.mit.edu	37	chr19	52496893	52496893	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	atatatatggcttctctgcaGtatgagttcgctgatgtaca	9	7	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:52496893G>C	uc002pye.1	-	6	1728	c.1436C>G	c.(1435-1437)ACT>AGT	p.T479S	ZNF615_uc002pyf.1_Missense_Mutation_p.T490S|ZNF615_uc002pyg.1_Missense_Mutation_p.T371S|ZNF615_uc002pyh.1_Missense_Mutation_p.T490S|ZNF615_uc010epi.1_Missense_Mutation_p.T486S|ZNF615_uc010ydg.1_Missense_Mutation_p.T484S	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CTTCTCTGCAGTATGAGTTCG	0.438													0	0	0	0.004672	0	3	20										C	52496893	G	C	52496893	3	2	104	1	0	0	0	0	1	0	0	0	18037	1029	36	4	763	4	ZNF615	19	52496893	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	3161962	52496893	6632090	178	32132										
NLRP4	147945	broad.mit.edu	37	chr19	56369402	56369402	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agtggcctgaccccgctgctCctataacagagatcgtgtct	10	13	1	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:56369402C>T	uc002qmd.3	+	3	1065	c.643C>T	c.(643-645)CCT>TCT	p.P215S	NLRP4_uc002qmf.2_Missense_Mutation_p.P140S|NLRP4_uc010etf.2_Missense_Mutation_p.P46S	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	215	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCCCGCTGCTCCTATAACAGA	0.537													0	0	0	0.005524	0	34	80										T	56369402	C	T	56369402	3	4	104	1	0	0	0	0	1	0	0	0	10479	855	30	1	649	1	NLRP4	19	56369402	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	3872509	56369402	2759581	179	32133										
ZNF776	284309	broad.mit.edu	37	chr19	58265972	58265972	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aaaggccacatgagtgtggaGaatgtggaaagtgttttcgt	14	4	0	2			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr19:58265972G>C	uc002qpx.2	+	3	1697	c.1474G>C	c.(1474-1476)GAA>CAA	p.E492Q	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.E492Q	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	492	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		TGAGTGTGGAGAATGTGGAAA	0.428													0	0	0	0.010818	0	29	68										C	58265972	G	C	58265972	3	2	104	1	0	0	0	0	1	0	0	0	18146	943	33	1	1484	1	ZNF776	19	58265972	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	1896570	58265972	863011	180	32134										
CEP250	11190	broad.mit.edu	37	chr20	34063379	34063379	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	agtcagaatcactcagtgaaCtgatcactcttcgggaagcc	9	11	5	3			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr20:34063379C>T	uc002xcm.2	+	16	2295	c.1624C>T	c.(1624-1626)CTG>TTG	p.L542L	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_Intron	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	542	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ACTCAGTGAACTGATCACTCT	0.552													0	0	0	0.01441	0	76	199										T	34063379	C	T	34063379	2	4	104	1	0	0	0	0	0	0	0	1	3252	564	20	2		2	CEP250	20	34063379	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		34063379	28962141	181	32135										
PRIC285	85441	broad.mit.edu	37	chr20	62198304	62198304	+	Missense_Mutation	SNP	C	C	T													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctcgacgacctgcgcaatctCagccagattcagccaggacg							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr20:62198304C>T	uc002yfm.2	-	7	3299	c.2407G>A	c.(2407-2409)GAG>AAG	p.E803K	PRIC285_uc002yfl.1_Missense_Mutation_p.E234K	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	803					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGCGCAATCTCAGCCAGATTC	0.662													0	0	0	0.004289	0	29	137										T	62198304	C	T	62198304	3	4	104	1	0	0	0	0	1	0	0	0	12485	835	29	1	5598	1	PRIC285	20	62198304	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	28134925	62198304	827216	182	32136	161	2								
PRIC285	85441	broad.mit.edu	37	chr20	62198314	62198314	+	Silent	SNP	C	C	T													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tgcgcaatctcagccagattCagccaggacgccatggacat							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr20:62198314C>T	uc002yfm.2	-	7	3289	c.2397G>A	c.(2395-2397)CTG>CTA	p.L799L	PRIC285_uc002yfl.1_Silent_p.L230L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	799					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CAGCCAGATTCAGCCAGGACG	0.672													0	0	0	0.003271	0	27	131										T	62198314	C	T	62198314	2	4	104	1	0	0	0	0	0	0	0	1	12485	813	29	1		1	PRIC285	20	62198314	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	10	62198314	827206	183	32137	161	2								
RIPK4	54101	broad.mit.edu	37	chr21	43161772	43161772	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tccacctcgttgaccgaggcGttcttctccaacagcagccg	9	16	2	1	rs143300354		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr21:43161772G>A	uc002yzn.1	-	8	1629	c.1581C>T	c.(1579-1581)AAC>AAT	p.N527N		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	527						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						TGACCGAGGCGTTCTTCTCCA	0.627													0	0	0	0.010729	0	12	55										A	43161772	G	A	43161772	2	1	104	1	0	0	0	0	0	0	0	1	13383	1136	40	2		2	RIPK4	21	43161772	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		43161772	4968123	184	32138										
GGT1	2678	broad.mit.edu	37	chr22	25023476	25023476	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gacgacaccactcacccgatCtcctactacaagcccgagtt	6	17	2	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:25023476C>A	uc003aan.1	+	12	1585	c.1098C>A	c.(1096-1098)ATC>ATA	p.I366I	GGT1_uc003aas.1_Silent_p.I366I|GGT1_uc003aat.1_Silent_p.I366I|GGT1_uc003aau.1_Silent_p.I366I|GGT1_uc003aav.1_Silent_p.I366I|GGT1_uc003aaw.1_Silent_p.I366I|GGT1_uc003aax.1_Silent_p.I366I|GGT1_uc003aay.1_Silent_p.I22I	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	366	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	CTCACCCGATCTCCTACTACA	0.642													1	0	6.68952e-21	0.013114	7.10762e-21	35	81										A	25023476	C	A	25023476	2	1	104	1	0	0	0	0	0	0	0	1	6361	903	32	3		3	GGT1	22	25023476	Silent	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08		25023476	26281090	185	32139										
SSTR3	6753	broad.mit.edu	37	chr22	37603104	37603104	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gcgttcggagcgccgccgccGctggcacgagggtgcccaca	16	16	0	0	rs146500640	byFrequency	TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:37603104G>A	uc003ara.2	-	2	801	c.739C>T	c.(739-741)CGG>TGG	p.R247W	SSTR3_uc003arb.2_Missense_Mutation_p.R247W	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	247	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						CGCCGCCGCCGCTGGCACGAG	0.672													0	0	0	0.00333	0	16	31										A	37603104	G	A	37603104	3	1	104	1	0	0	0	0	1	0	0	0	15198	1086	38	2	521	2	SSTR3	22	37603104	Missense_Mutation	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08	12579628	37603104	13701462	186	32140										
EP300	2033	broad.mit.edu	37	chr22	41572411	41572411	+	Frame_Shift_Del	DEL	C	C	-													0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	gttctcttcactccgaagagCccagtggtccaccatgtgca							TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:41572411delC	uc003azl.3	+	30	5335	c.4940delC	c.(4939-4941)GCCfs	p.A1647fs		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1647	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTCCGAAGAGCCCAGTGGTCC	0.572			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome									27	68	---	---								-	41572411	C	-	41572411	7	5	104	1	0	1	0	1	0	0	0	0	5148	739	26	0	5058	0	EP300	22	41572411	Frame_Shift_Del	DEL	C	TCGA-GC-A3RB-01A-12D-A21Z-08	3969307	41572411	9732155	187	32141										
PMM1	5372	broad.mit.edu	37	chr22	41982104	41982104	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	atccccgtcacccagctgctCagcgatcttacagtagtcag	8	15	4	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:41982104C>T	uc003bal.2	-	2	243	c.181G>A	c.(181-183)GAG>AAG	p.E61K		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	61					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						CCCAGCTGCTCAGCGATCTTA	0.567													0	0	0	0.01441	0	53	129										T	41982104	C	T	41982104	3	4	104	1	0	0	0	0	1	0	0	0	12136	835	29	1	635	1	PMM1	22	41982104	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	409693	41982104	9322462	188	32142										
PMM1	5372	broad.mit.edu	37	chr22	41982185	41982185	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ctgcaggaaggcggccacctCagggtcaattttctatgggg	14	10	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chr22:41982185C>G	uc003bal.2	-	2	162	c.100G>C	c.(100-102)GAG>CAG	p.E34Q		NM_002676	NP_002667	Q92871	PMM1_HUMAN	phosphomannomutase 1	34					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1						GCGGCCACCTCAGGGTCAATT	0.562													0	0	0	0.01441	0	43	149										G	41982185	C	G	41982185	3	3	104	1	0	0	0	0	1	0	0	0	12136	835	29	1	716	1	PMM1	22	41982185	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	81	41982185	9322381	189	32143										
GATA1	2623	broad.mit.edu	37	chrX	48650333	48650333	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	ggctgggcctacggcaagacGgggctctaccctgcctcaac	13	15	2	1	rs145355350		TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:48650333G>A	uc004dkq.3	+	3	394	c.303G>A	c.(301-303)ACG>ACA	p.T101T		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	101					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)|p.V77_A120>A(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						ACGGCAAGACGGGGCTCTACC	0.612			Mis|F		megakaryoblastic leukemia of Downs Syndrome								0	0	0	0.004878	0	38	4										A	48650333	G	A	48650333	2	1	104	1	0	0	0	0	0	0	0	1	6253	1103	39	2		2	GATA1	23	48650333	Silent	SNP	G	TCGA-GC-A3RB-01A-12D-A21Z-08		48650333	106620227	190	32144										
AWAT2	158835	broad.mit.edu	37	chrX	69262998	69262998	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	acctggcaggctgtatctgcActcagccagtccaccaatca	8	15	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:69262998A>T	uc004dxt.1	-	5	574	c.568T>A	c.(568-570)TGC>AGC	p.C190S		NM_001002254	NP_001002254	Q6E213	AWAT2_HUMAN	wax synthase 2	190						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity				0						CTGTATCTGCACTCAGCCAGT	0.547													0	0	0	0.009096	0	3	6										T	69262998	A	T	69262998	3	4	104	1	0	0	0	0	1	0	0	0	1235	159	6	5	445	5	AWAT2	23	69262998	Missense_Mutation	SNP	A	TCGA-GC-A3RB-01A-12D-A21Z-08	20612665	69262998	86007562	191	32145										
NXF5	55998	broad.mit.edu	37	chrX	101095527	101095527	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	aacgggttcccttctagccaTagctcttcgagcttcagccc	8	15	3	0			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:101095527T>C	uc011mrk.1	-	10	1002	c.642A>G	c.(640-642)CTA>CTG	p.L214L	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	214	LRR 3.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						CTTCTAGCCATAGCTCTTCGA	0.577													0	0	0	0.010504	0	14	70										C	101095527	T	C	101095527	2	2	104	1	0	0	0	0	0	0	0	1	10786	1393	49	5		5	NXF5	23	101095527	Silent	SNP	T	TCGA-GC-A3RB-01A-12D-A21Z-08	31832529	101095527	54175033	192	32146										
WDR44	54521	broad.mit.edu	37	chrX	117578414	117578414	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410526315789474	78	1.05263490468906e-25	3.62502706213466	4.9858064516129	2.93776474421636	0.434434737482652	0.656703672938893	56	tctgaaaaatcagaagggaaCgagaaaagtgaagatgctga	12	4	2	6			TCGA-GC-A3RB-01A-12D-A21Z-08	TCGA-GC-A3RB-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eaf54383-4286-4416-9b18-be1081797df2	dfd4328e-f7a5-4bf9-bdf6-a8a293d14283	g.chrX:117578414C>G	uc004eqn.2	+	19	3029	c.2604C>G	c.(2602-2604)AAC>AAG	p.N868K	WDR44_uc004eqo.2_Missense_Mutation_p.N860K|WDR44_uc011mtr.1_Missense_Mutation_p.N779K|WDR44_uc010nqi.2_Missense_Mutation_p.N578K	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	868						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CAGAAGGGAACGAGAAAAGTG	0.388													0	0	0	0.011902	0	44	52										G	117578414	C	G	117578414	3	3	104	1	0	0	0	0	1	0	0	0	17293	535	19	4	2678	4	WDR44	23	117578414	Missense_Mutation	SNP	C	TCGA-GC-A3RB-01A-12D-A21Z-08	16482887	117578414	37692146	193	32147										
ACAP3	116983	broad.mit.edu	37	chr1	1235580	1235580	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttcttggcctgcagaacattGatctgccagagggggagccc	13	11	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:1235580G>A	uc001aeb.2	-	7	599	c.525C>T	c.(523-525)ATC>ATT	p.I175I	ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Silent_p.I133I|ACAP3_uc001aec.1_Silent_p.I133I	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	175					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						GCAGAACATTGATCTGCCAGA	0.632													0	0	0	0.013537	0	13	15										A	1235580	G	A	1235580	2	1	105	1	0	0	0	0	0	0	0	1	120	1280	45	1		1	ACAP3	1	1235580	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		1235580	248015041	1	32148										
TAS1R3	83756	broad.mit.edu	37	chr1	1267925	1267925	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacgagttcccccagtacgtGaagacgcacctggccctggc	11	16	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:1267925G>A	uc010nyk.1	+	3	1014	c.1014G>A	c.(1012-1014)GTG>GTA	p.V338V		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	338	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CCCAGTACGTGAAGACGCACC	0.701													0	0	0	0.004482	0	9	27										A	1267925	G	A	1267925	2	1	105	1	0	0	0	0	0	0	0	1	15561	1277	45	1		1	TAS1R3	1	1267925	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	32345	1267925	247982696	2	32149										
TAS1R3	83756	broad.mit.edu	37	chr1	1268955	1268955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagcacacgctgcttccgccGcaggtctcggttcctggcat	11	15	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:1268955G>A	uc010nyk.1	+	6	1670	c.1670G>A	c.(1669-1671)CGC>CAC	p.R557H		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	557	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGCTTCCGCCGCAGGTCTCGG	0.657													0	0	0	0.010729	0	11	31										A	1268955	G	A	1268955	3	1	105	1	0	0	0	0	1	0	0	0	15561	1087	38	2	1692	2	TAS1R3	1	1268955	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1030	1268955	247981666	3	32150										
LRRC47	57470	broad.mit.edu	37	chr1	3697705	3697705	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggccaggtcggccttggacgGgtacaccaccttcaggctcc	13	15	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:3697705G>A	uc001akx.1	-	7	1727	c.1699C>T	c.(1699-1701)CCG>TCG	p.P567S		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	567					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		GCCTTGGACGGGTACACCACC	0.652													0	0	0	0.006122	0	18	45										A	3697705	G	A	3697705	3	1	105	1	0	0	0	0	1	0	0	0	9004	1232	43	2	56	2	LRRC47	1	3697705	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2428750	3697705	245552916	4	32151										
H6PD	9563	broad.mit.edu	37	chr1	9305294	9305294	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	actgtgcagagcacaaggatCagttcctgcagctgagccag	12	11	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:9305294C>T	uc001apt.2	+	2	574	c.301C>T	c.(301-303)CAG>TAG	p.Q101*		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	101	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GCACAAGGATCAGTTCCTGCA	0.617													0	0	0	0.019004	0	39	29										T	9305294	C	T	9305294	4	4	105	1	0	0	0	0	0	1	0	0	6936	827	29	1	303	1	H6PD	1	9305294	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5607589	9305294	239945327	5	32152										
VPS13D	55187	broad.mit.edu	37	chr1	12401928	12401928	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgtggtttgccaccctgacCaccacacccaccaggtaagc	8	16	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:12401928C>T	uc001atv.2	+	41	8859	c.8718C>T	c.(8716-8718)ACC>ACT	p.T2906T	VPS13D_uc001atw.2_Silent_p.T2881T|VPS13D_uc001atx.2_Silent_p.T2093T	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2905					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCACCCTGACCACCACACCCA	0.572													0	0	0	0.008871	0	18	70										T	12401928	C	T	12401928	2	4	105	1	0	0	0	0	0	0	0	1	17189	581	21	2		2	VPS13D	1	12401928	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3096634	12401928	236848693	6	32153										
SPEN	23013	broad.mit.edu	37	chr1	16265886	16265886	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cttgccagcatctccaacatCtctccccacctcatgattgt	4	17	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:16265886C>T	uc001axk.1	+	15	11163	c.10959C>T	c.(10957-10959)ATC>ATT	p.I3653I	SPEN_uc010obp.1_Silent_p.I3612I	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3653	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCTCCAACATCTCTCCCCACC	0.557													0	0	0	0.01441	0	57	138										T	16265886	C	T	16265886	2	4	105	1	0	0	0	0	0	0	0	1	15037	903	32	1		1	SPEN	1	16265886	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3863958	16265886	232984735	7	32154										
UBR4	23352	broad.mit.edu	37	chr1	19439182	19439182	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtgtgatacaatgttctgtGacagccgaggcgcagccata	12	9	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:19439182G>A	uc001bbi.2	-	78	11641	c.11637C>T	c.(11635-11637)GTC>GTT	p.V3879V	UBR4_uc001bbj.1_3'UTR	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3879					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AATGTTCTGTGACAGCCGAGG	0.582													0	0	0	0.011902	0	44	112										A	19439182	G	A	19439182	2	1	105	1	0	0	0	0	0	0	0	1	16901	1277	45	1		1	UBR4	1	19439182	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3173296	19439182	229811439	8	32155										
HTR6	3362	broad.mit.edu	37	chr1	19992501	19992501	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtgatgccgccggccatgctGaacgcgctgtacgggcgctg	16	13	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:19992501G>A	uc001bcl.2	+	1	722	c.255G>A	c.(253-255)CTG>CTA	p.L85L		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	85	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CGGCCATGCTGAACGCGCTGT	0.667													0	0	0	0.00308	0	8	36										A	19992501	G	A	19992501	2	1	105	1	0	0	0	0	0	0	0	1	7451	1277	45	1		1	HTR6	1	19992501	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	553319	19992501	229258120	9	32156										
RAP1GAP	5909	broad.mit.edu	37	chr1	21940120	21940120	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcagcggagcggagacctcaCctttgccatctggacaacat	10	13	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:21940120C>A	uc001bex.2	-	9	732	c.474_splice	c.e9+1	p.K158_splice	RAP1GAP_uc001bev.2_Splice_Site_p.K158_splice|RAP1GAP_uc001bew.2_Splice_Site_p.K222_splice|RAP1GAP_uc001bey.2_Splice_Site_p.K158_splice	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c						regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GGAGACCTCACCTTTGCCATC	0.597													1	0	1.16021e-09	0.007291	1.21631e-09	28	36										A	21940120	C	A	21940120	5	1	105	1	0	0	0	0	0	0	1	0	13037	521	18	4	1662	4	RAP1GAP	1	21940120	Splice_Site	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1947619	21940120	227310501	10	32157										
MYOM3	127294	broad.mit.edu	37	chr1	24408602	24408602	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgccacctccacgacgcttGgggggtttccacccaatgac	10	15	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:24408602G>C	uc001bin.3	-	18	2332	c.2169C>G	c.(2167-2169)CCC>CCG	p.P723P	MYOM3_uc001bim.3_Silent_p.P380P|MYOM3_uc001bio.2_Silent_p.P723P|MYOM3_uc001bip.1_3'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	723	Fibronectin type-III 4.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CACGACGCTTGGGGGGTTTCC	0.592													0	0	0	0.00308	0	8	18										C	24408602	G	C	24408602	2	2	105	1	0	0	0	0	0	0	0	1	10093	1335	47	4		4	MYOM3	1	24408602	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2468482	24408602	224842019	11	32158										
SEPN1	57190	broad.mit.edu	37	chr1	26135144	26135144	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagtgcagtgtttgccacccGccacttccagcccttccttc	7	17	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:26135144G>A	uc010oer.1	+	7	666	c.611G>A	c.(610-612)CGC>CAC	p.R204H	SEPN1_uc010oes.1_Missense_Mutation_p.R170H	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	204						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		TTTGCCACCCGCCACTTCCAG	0.657													0	0	0	0.015359	0	34	58										A	26135144	G	A	26135144	3	1	105	1	0	0	0	0	1	0	0	0	14056	1087	38	2	629	2	SEPN1	1	26135144	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1726542	26135144	223115477	12	32159										
ARID1A	8289	broad.mit.edu	37	chr1	27059194	27059194	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctcaagattcatttgggtctCaggcatcctcagccccctca	7	15	5	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:27059194C>T	uc001bmv.1	+	4	2204	c.1831C>T	c.(1831-1833)CAG>TAG	p.Q611*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q611*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q611*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q228*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	611					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATTTGGGTCTCAGGCATCCTC	0.478			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.006122	0	19	69										T	27059194	C	T	27059194	4	4	105	1	0	0	0	0	0	1	0	0	913	827	29	1	1845	1	ARID1A	1	27059194	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	924050	27059194	222191427	13	32160										
FGR	2268	broad.mit.edu	37	chr1	27948152	27948152	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggagctgagagaccgagcctCccaccagtcaccttcactgt	10	15	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:27948152C>T	uc001boj.2	-	3	492	c.346G>A	c.(346-348)GAG>AAG	p.E116K	FGR_uc001bok.2_Missense_Mutation_p.E116K|FGR_uc001bol.2_Missense_Mutation_p.E116K|FGR_uc001bom.2_Missense_Mutation_p.E116K	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	116	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GACCGAGCCTCCCACCAGTCA	0.592													0	0	0	0.00245	0	14	44										T	27948152	C	T	27948152	3	4	105	1	0	0	0	0	1	0	0	0	5874	864	30	1	1279	1	FGR	1	27948152	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	888958	27948152	221302469	14	32161										
PTPRU	10076	broad.mit.edu	37	chr1	29585795	29585795	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctgtttgaggccctcatctCcccagaccgcaggggctaca	11	15	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:29585795C>G	uc001bru.2	+	4	610	c.500C>G	c.(499-501)TCC>TGC	p.S167C	PTPRU_uc001brv.2_Missense_Mutation_p.S167C|PTPRU_uc001brw.2_Missense_Mutation_p.S167C|PTPRU_uc009vtq.2_Missense_Mutation_p.S167C|PTPRU_uc009vtr.2_Missense_Mutation_p.S167C	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	167	Extracellular (Potential).|MAM.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCCCTCATCTCCCCAGACCGC	0.642													0	0	0	0.00308	0	7	38										G	29585795	C	G	29585795	3	3	105	1	0	0	0	0	1	0	0	0	12813	855	30	1	514	1	PTPRU	1	29585795	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1637643	29585795	219664826	15	32162										
SPOCD1	90853	broad.mit.edu	37	chr1	32257898	32257898	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	accatccccatgtgctccacAgaggccagcccgtggcgctg	11	17	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:32257898A>T	uc001bts.1	-	15	2938	c.2880T>A	c.(2878-2880)TCT>TCA	p.S960S	SPOCD1_uc001btr.1_Silent_p.S48S|SPOCD1_uc001btt.2_Silent_p.S265S|SPOCD1_uc001btu.2_Silent_p.S960S|SPOCD1_uc001btv.2_Silent_p.S453S	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	960	SPOC.				transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGTGCTCCACAGAGGCCAGCC	0.667													0	0	0	0.004482	0	8	11										T	32257898	A	T	32257898	2	4	105	1	0	0	0	0	0	0	0	1	15077	175	7	5		5	SPOCD1	1	32257898	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	2672103	32257898	216992723	16	32163										
RBBP4	5928	broad.mit.edu	37	chr1	33134689	33134689	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtttcctggcatctactccaTgagtctctgtttgggtcagt	10	10	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:33134689T>C	uc001bvr.2	+	6	876	c.717T>C	c.(715-717)CAT>CAC	p.H239H	RBBP4_uc001bvs.2_Silent_p.H238H|RBBP4_uc010ohj.1_5'UTR|RBBP4_uc010ohk.1_Silent_p.H204H	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	239	WD 3.				cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				ATCTACTCCATGAGTCTCTGT	0.413													0	0	0	0.01441	0	53	70										C	33134689	T	C	33134689	2	2	105	1	0	0	0	0	0	0	0	1	13101	1461	51	5		5	RBBP4	1	33134689	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	876791	33134689	216115932	17	32164										
GJB4	127534	broad.mit.edu	37	chr1	35227557	35227557	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaatgcctacccgatacgtgCccaccatatgtcctctccca	6	17	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:35227557C>T	uc001bxv.1	+	2	1072	c.702C>T	c.(700-702)TGC>TGT	p.C234C	GJB4_uc001bxw.3_Silent_p.C234C	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	234	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CCGATACGTGCCCACCATATG	0.612													0	0	0	0.005443	0	26	47										T	35227557	C	T	35227557	2	4	105	1	0	0	0	0	0	0	0	1	6410	747	26	2		2	GJB4	1	35227557	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2092868	35227557	214023064	18	32165										
THRAP3	9967	broad.mit.edu	37	chr1	36754808	36754808	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctgattcttttgctcccaaAactgattctgagaagccttt	6	10	3	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:36754808A>C	uc001cae.3	+	5	1412	c.1188A>C	c.(1186-1188)AAA>AAC	p.K396N	THRAP3_uc001caf.3_Missense_Mutation_p.K396N|THRAP3_uc001cag.1_Missense_Mutation_p.K396N	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	396					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTGCTCCCAAAACTGATTCTG	0.418			T	USP6	aneurysmal bone cysts								0	0	0	0.005443	0	29	68										C	36754808	A	C	36754808	3	2	105	1	0	0	0	0	1	0	0	0	15871	11	1	5	1198	5	THRAP3	1	36754808	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	1527251	36754808	212495813	19	32166										
DPH2	1802	broad.mit.edu	37	chr1	44435913	44435913	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagaccggggtgccaggactGcttactcctcttccggacct	12	14	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:44435913G>A	uc001ckz.2	+	1	261	c.66G>A	c.(64-66)CTG>CTA	p.L22L	DPH2_uc001cla.2_Silent_p.L22L|DPH2_uc010okk.1_5'UTR|DPH2_uc001clb.2_5'UTR	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	22					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				TGCCAGGACTGCTTACTCCTC	0.632													0	0	0	0.015359	0	35	35										A	44435913	G	A	44435913	2	1	105	1	0	0	0	0	0	0	0	1	4720	1306	46	2		2	DPH2	1	44435913	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7681105	44435913	204814708	20	32167										
LRRC42	115353	broad.mit.edu	37	chr1	54417905	54417905	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttcatcttcacatacacccGagaggggaatcttcggtact	8	11	4	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:54417905G>T	uc001cwj.1	+	2	433	c.233G>T	c.(232-234)CGA>CTA	p.R78L	LRRC42_uc001cwl.1_Missense_Mutation_p.R78L|LRRC42_uc001cwk.1_Missense_Mutation_p.R78L|LRRC42_uc009vzm.1_Missense_Mutation_p.R78L	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	78											0						ACATACACCCGAGAGGGGAAT	0.483													1	0	2.24059e-21	0.00632	2.43367e-21	30	97										T	54417905	G	T	54417905	3	4	105	1	0	0	0	0	1	0	0	0	9000	1058	37	3	235	3	LRRC42	1	54417905	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	9981992	54417905	194832716	21	32168										
TMEM61	199964	broad.mit.edu	37	chr1	55452006	55452006	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggcctgctgctgctcattggCctgctgtggtccgtcaaggc	14	13	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:55452006C>A	uc001cyd.2	+	2	526	c.252C>A	c.(250-252)GGC>GGA	p.G84G		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	84	Helical; (Potential).					integral to membrane					0						TGCTCATTGGCCTGCTGTGGT	0.647													1	0	3.01185e-09	0.003954	3.15139e-09	26	94										A	55452006	C	A	55452006	2	1	105	1	0	0	0	0	0	0	0	1	16185	726	26	4		4	TMEM61	1	55452006	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1034101	55452006	193798615	22	32169										
DOCK7	85440	broad.mit.edu	37	chr1	62939693	62939693	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcagagtcgcagtttattatGatgtctgaagagctttgggt	13	5	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:62939693G>C	uc001daq.2	-	47	6173	c.6139C>G	c.(6139-6141)CAT>GAT	p.H2047D	DOCK7_uc001dan.2_Missense_Mutation_p.H1910D|DOCK7_uc001dao.2_Missense_Mutation_p.H1908D|DOCK7_uc001dap.2_Missense_Mutation_p.H2027D|DOCK7_uc001dam.2_Missense_Mutation_p.H1229D|DOCK7_uc010oov.1_Missense_Mutation_p.H788D|DOCK7_uc001dar.1_Missense_Mutation_p.H221D	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2058	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGTTTATTATGATGTCTGAAG	0.368													0	0	0	0.00499	0	14	29										C	62939693	G	C	62939693	3	2	105	1	0	0	0	0	1	0	0	0	4692	1290	45	1	262	1	DOCK7	1	62939693	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7487687	62939693	186310928	23	32170										
TNNI3K	51086	broad.mit.edu	37	chr1	74737353	74737353	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caggttggatacggtggcctCactgccctccatattgctac	10	13	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:74737353C>T	uc001dgf.1	+	5	456	c.405C>T	c.(403-405)CTC>CTT	p.L135L	TNNI3K_uc001dgc.1_Silent_p.L236L|TNNI3K_uc001dgd.2_Silent_p.L236L|TNNI3K_uc001dge.1_Silent_p.L236L	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	135	ANK 3.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						ACGGTGGCCTCACTGCCCTCC	0.433													0	0	0	0.005524	0	38	57										T	74737353	C	T	74737353	2	4	105	1	0	0	0	0	0	0	0	1	16326	813	29	1		1	TNNI3K	1	74737353	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	11797660	74737353	174513268	24	32171										
WDR63	126820	broad.mit.edu	37	chr1	85592370	85592370	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aacatttgcataactatgatCacctacatcaaaccctggat	4	11	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:85592370C>G	uc001dkt.2	+	20	2480	c.2289C>G	c.(2287-2289)ATC>ATG	p.I763M	WDR63_uc009wcl.2_Missense_Mutation_p.I724M	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	763	WD 5.									upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TAACTATGATCACCTACATCA	0.383													0	0	0	0.007291	0	27	46										G	85592370	C	G	85592370	3	3	105	1	0	0	0	0	1	0	0	0	17311	816	29	1	2363	1	WDR63	1	85592370	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10855017	85592370	163658251	25	32172										
LPPR5	163404	broad.mit.edu	37	chr1	99387566	99387566	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	taagcccaagcatagaactgGcttagcaagtctggttccct	9	11	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:99387566G>A	uc001dsb.2	-	4	892	c.670C>T	c.(670-672)CCA>TCA	p.P224S	LPPR5_uc001dsc.2_Missense_Mutation_p.P224S	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	224						integral to membrane	hydrolase activity				0						CATAGAACTGGCTTAGCAAGT	0.368													0	0	0	0.013537	0	13	36										A	99387566	G	A	99387566	3	1	105	1	0	0	0	0	1	0	0	0	8928	1203	42	2	307	2	LPPR5	1	99387566	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	13795196	99387566	149863055	26	32173										
PSMA5	5686	broad.mit.edu	37	chr1	109957934	109957934	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggaagtaattctcttctccaCagctaggcacacaccctctg	7	14	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:109957934C>G	uc001dxn.2	-	3	233	c.148G>C	c.(148-150)GTG>CTG	p.V50L	PSMA5_uc010ovj.1_5'UTR	NM_002790	NP_002781	P28066	PSA5_HUMAN	proteasome alpha 5 subunit	50					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity				0		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.045)|Colorectal(144;0.116)|Epithelial(280;0.187)|all cancers(265;0.196)|LUSC - Lung squamous cell carcinoma(189;0.235)		CTCTTCTCCACAGCTAGGCAC	0.433													0	0	0	0.00632	0	29	31										G	109957934	C	G	109957934	3	3	105	1	0	0	0	0	1	0	0	0	12670	478	17	4	605	4	PSMA5	1	109957934	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10570368	109957934	139292687	27	32174										
GSTM4	2948	broad.mit.edu	37	chr1	110199865	110199865	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tatgacagaagccagtggctGaatgaaaaattcaagctggg	12	6	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:110199865G>A	uc001dyf.2	+	3	455	c.141G>A	c.(139-141)CTG>CTA	p.L47L	GSTM4_uc009wfi.2_3'UTR|GSTM4_uc001dyg.2_5'UTR|GSTM4_uc009wfj.2_Silent_p.L47L|GSTM4_uc001dyh.2_Silent_p.L47L|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841	Q03013	GSTM4_HUMAN	glutathione S-transferase mu 4 isoform 1	47	Glutathione binding (By similarity).|GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	GCCAGTGGCTGAATGAAAAAT	0.567													0	0	0	0.012319	0	19	44										A	110199865	G	A	110199865	2	1	105	1	0	0	0	0	0	0	0	1	6840	1277	45	1		1	GSTM4	1	110199865	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	241931	110199865	139050756	28	32175										
PRPF3	9129	broad.mit.edu	37	chr1	150307445	150307445	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caaacgaaacctacaccactGatcctggatgagcaagggcg	10	12	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:150307445G>T	uc001eum.3	+	7	930	c.768G>T	c.(766-768)CTG>CTT	p.L256L	PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Silent_p.L215L|PRPF3_uc010pcb.1_Silent_p.L207L|PRPF3_uc009wlq.1_RNA	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	256					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CTACACCACTGATCCTGGATG	0.448													1	0	0.000308642	0.003163	0.000315036	14	11										T	150307445	G	T	150307445	2	4	105	1	0	0	0	0	0	0	0	1	12565	1277	45	3		3	PRPF3	1	150307445	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	40107580	150307445	98943176	29	32176										
TARS2	80222	broad.mit.edu	37	chr1	150471769	150471769	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggtgccttctatggacctaaGgtaagcttgggaccctggtt	13	9	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:150471769G>T	uc001euq.2	+	13	1624	c.1617G>T	c.(1615-1617)AAG>AAT	p.K539N	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.K457N|TARS2_uc009wlt.2_Missense_Mutation_p.K165N|TARS2_uc009wls.2_Missense_Mutation_p.K409N	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	539					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	ATGGACCTAAGGTAAGCTTGG	0.348													1	0	2.24722e-20	0.01441	2.43599e-20	48	80										T	150471769	G	T	150471769	3	4	105	1	0	0	0	0	1	0	0	0	15557	1014	35	4	1667	4	TARS2	1	150471769	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	164324	150471769	98778852	30	32177										
F11R	50848	broad.mit.edu	37	chr1	160970508	160970508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtatgtcccagtgtcttcccGtgtcacggacttgaaggtga	12	10	2	2	rs116727809	byFrequency	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:160970508G>A	uc009wtt.2	-	4	571	c.301C>T	c.(301-303)CGG>TGG	p.R101W	F11R_uc010pjv.1_Intron|F11R_uc001fxe.3_Missense_Mutation_p.R101W|F11R_uc009wtu.2_Missense_Mutation_p.R101W|F11R_uc010pjw.1_Missense_Mutation_p.R105W|F11R_uc001fxf.3_Missense_Mutation_p.R101W	NM_016946	NP_058642	Q9Y624	JAM1_HUMAN	F11 receptor precursor	101	Extracellular (Potential).|Ig-like V-type 1.				blood coagulation|inflammatory response|interspecies interaction between organisms|leukocyte migration|tight junction assembly	integral to membrane|tight junction				ovary(2)	2	all_cancers(52;6.73e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00207)			GTGTCTTCCCGTGTCACGGAC	0.542													0	0	0	0.016723	0	13	38										A	160970508	G	A	160970508	3	1	105	1	0	0	0	0	1	0	0	0	5338	1144	40	2	626	2	F11R	1	160970508	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	10498739	160970508	88280113	31	32178										
TNR	7143	broad.mit.edu	37	chr1	175334312	175334312	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcctcatccctggggctgtaGttaagaatgagtctgtctgc	11	10	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:175334312G>A	uc001gkp.1	-	10	2502	c.2421C>T	c.(2419-2421)AAC>AAT	p.N807N	TNR_uc009wwu.1_Silent_p.N807N	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	807	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TGGGGCTGTAGTTAAGAATGA	0.532													0	0	0	0.010729	0	11	28										A	175334312	G	A	175334312	2	1	105	1	0	0	0	0	0	0	0	1	16335	1020	36	2		2	TNR	1	175334312	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	14363804	175334312	73916309	32	32179										
PAPPA2	60676	broad.mit.edu	37	chr1	176659286	176659286	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	attgcaggtggcattgtcctCagcccagcatattatgggat	11	9	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:176659286C>T	uc001gkz.2	+	5	3315	c.2151C>T	c.(2149-2151)CTC>CTT	p.L717L	PAPPA2_uc001gky.1_Silent_p.L717L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	717	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCATTGTCCTCAGCCCAGCAT	0.423													0	0	0	0.016522	0	24	60										T	176659286	C	T	176659286	2	4	105	1	0	0	0	0	0	0	0	1	11433	813	29	1		1	PAPPA2	1	176659286	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1324974	176659286	72591335	33	32180										
CACNA1E	777	broad.mit.edu	37	chr1	181745299	181745299	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tacctgactcgggactcctcCatcctggggcctcaccactt	8	17	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:181745299C>T	uc001gow.2	+	38	5367	c.5202C>T	c.(5200-5202)TCC>TCT	p.S1734S	CACNA1E_uc009wxs.2_Silent_p.S1622S|CACNA1E_uc001gox.1_Silent_p.S960S|CACNA1E_uc009wxt.2_Silent_p.S960S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1734	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GGGACTCCTCCATCCTGGGGC	0.607													0	0	0	0.001168	0	6	117										T	181745299	C	T	181745299	2	4	105	1	0	0	0	0	0	0	0	1	2542	581	21	2		2	CACNA1E	1	181745299	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5086013	181745299	67505322	34	32181										
RGS16	6004	broad.mit.edu	37	chr1	182572448	182572448	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgatttgtgaagaaagatcCccagacgtgtcttgaactct	9	9	2	6			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:182572448C>A	uc001gpl.3	-	2	225	c.71G>T	c.(70-72)GGG>GTG	p.G24V	RGS16_uc010pnv.1_Missense_Mutation_p.G24V	NM_002928	NP_002919	O15492	RGS16_HUMAN	regulator of G-protein signalling 16	24					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(1)	1						AAGAAAGATCCCCAGACGTGT	0.478													1	0	3.65163e-15	0.00632	3.87316e-15	26	36										A	182572448	C	A	182572448	3	1	105	1	0	0	0	0	1	0	0	0	13298	623	22	4	553	4	RGS16	1	182572448	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	827149	182572448	66678173	35	32182										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185269206	185269206	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acaatttttcagtcctttttGaccatatggatcagagccac	6	10	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:185269206G>A	uc001grl.2	-	13	2049	c.1426C>T	c.(1426-1428)CAA>TAA	p.Q476*	IVNS1ABP_uc001gri.2_Nonsense_Mutation_p.Q136*|IVNS1ABP_uc001grj.2_Nonsense_Mutation_p.Q136*|IVNS1ABP_uc009wyj.2_Nonsense_Mutation_p.Q258*|IVNS1ABP_uc009wyk.2_RNA|IVNS1ABP_uc001grm.2_Nonsense_Mutation_p.Q136*	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	476	Kelch 3.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						AGTCCTTTTTGACCATATGGA	0.323													0	0	0	0.007413	0	19	30										A	185269206	G	A	185269206	4	1	105	1	0	0	0	0	0	1	0	0	7930	1299	45	1	514	1	IVNS1ABP	1	185269206	Nonsense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2696758	185269206	63981415	36	32183										
HMCN1	83872	broad.mit.edu	37	chr1	186057737	186057737	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtgctttgtttctacctctaGaaaattctgactcactggaa	7	9	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:186057737G>C	uc001grq.1	+	63	9807	c.9578_splice	c.e63-1	p.E3193_splice		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCTACCTCTAGAAAATTCTGA	0.338													0	0	0	0.006214	0	9	15										C	186057737	G	C	186057737	5	2	105	1	0	0	0	0	0	0	1	0	7220	956	33	1	9827	1	HMCN1	1	186057737	Splice_Site	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	788531	186057737	63192884	37	32184										
ASPM	259266	broad.mit.edu	37	chr1	197072405	197072405	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agaagagcagcttttttcatGattttccacttcttttgttg	7	7	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:197072405G>C	uc001gtu.2	-	18	6233	c.5976C>G	c.(5974-5976)ATC>ATG	p.I1992M	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1992	IQ 13.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTTTTTTCATGATTTTCCACT	0.338													0	0	0	0.005443	0	29	80										C	197072405	G	C	197072405	3	2	105	1	0	0	0	0	1	0	0	0	1056	1280	45	1	4501	1	ASPM	1	197072405	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	11014668	197072405	52178216	38	32185										
PHLDA3	23612	broad.mit.edu	37	chr1	201437720	201437728	+	In_Frame_Del	DEL	CTCCACGCA	CTCCACGCA	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tagatgtggcgcccggtgctCtccacgcactccacggcctt							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:201437720_201437728delCTCCACGCA	uc001gwq.2	-	1	572_580	c.187_195delTGCGTGGAG	c.(187-195)TGCGTGGAGdel	p.CVE63del	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	63_65	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						GCCCGGTGCTCTCCACGCACTCCACGGCC	0.689																		10	55	---	---								-	201437728	CTCCACGCA	-	201437720	7	5	105	1	0	1	0	1	0	0	0	0	11850	912	32	0	192	0	PHLDA3	1	201437720	In_Frame_Del	DEL	CTCCACGCA	TCGA-GC-A3RC-01A-11D-A22Z-08	4365315	201437720	47812901	39	32186										
IL19	29949	broad.mit.edu	37	chr1	207013293	207013294	+	In_Frame_Ins	INS	-	-	ATC													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	accccaaaatcttgagaaaaINSatcagcagcattgccaactc							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:207013293_207013294insATC	uc001hep.2	+	5	1248_1249	c.309_310insATC	c.(307-312)insATC	p.104_105insI	IL19_uc001heo.2_In_Frame_Ins_p.142_143insI|IL19_uc010prx.1_In_Frame_Ins_p.104_105insI	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	104_105					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			TCTTGAGAAAAATCAGCAGCAT	0.505																		57	102	---	---								ATC	207013294	-	ATC	207013293	7	5	105	1	0	1	1	0	0	0	0	0	7649	11	1	0	437	0	IL19	1	207013293	In_Frame_Ins	INS	-	TCGA-GC-A3RC-01A-11D-A22Z-08	5575573	207013293	42237328	40	32187										
CR2	1380	broad.mit.edu	37	chr1	207644106	207644106	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgccaggcccctcctaacaTcctcaatgggcaaaaggaag	9	13	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:207644106T>C	uc001hfw.2	+	7	1341	c.1247T>C	c.(1246-1248)ATC>ACC	p.I416T	CR2_uc001hfv.2_Missense_Mutation_p.I416T|CR2_uc009xch.2_Missense_Mutation_p.I416T|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	416	Sushi 7.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CCTCCTAACATCCTCAATGGG	0.408													0	0	0	0.006122	0	16	41										C	207644106	T	C	207644106	3	2	105	1	0	0	0	0	1	0	0	0	3842	1435	50	5	1273	5	CR2	1	207644106	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	630813	207644106	41606515	41	32188										
SLC30A1	7779	broad.mit.edu	37	chr1	211751728	211751728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagcccccattacctcggctCggatccagccgaacgtgttc	10	16	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:211751728C>T	uc001hio.1	-	1	372	c.227G>A	c.(226-228)CGA>CAA	p.R76Q		NM_021194	NP_067017	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter),	76	Cytoplasmic (Potential).				cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity	p.R76L(1)		ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		TACCTCGGCTCGGATCCAGCC	0.662													0	0	0	0.00308	0	8	13										T	211751728	C	T	211751728	3	4	105	1	0	0	0	0	1	0	0	0	14553	884	31	1	1304	1	SLC30A1	1	211751728	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4107622	211751728	37498893	42	32189										
MARK1	4139	broad.mit.edu	37	chr1	220825429	220825429	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccagaagtccatgtccacttCtggtcatcctattaaagtca	6	12	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:220825429C>G	uc001hmn.3	+	15	2270	c.1673C>G	c.(1672-1674)TCT>TGT	p.S558C	MARK1_uc009xdw.2_Missense_Mutation_p.S558C|MARK1_uc010pun.1_Missense_Mutation_p.S558C|MARK1_uc001hmm.3_Missense_Mutation_p.S536C	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	558					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		ATGTCCACTTCTGGTCATCCT	0.493													0	0	0	0.01892	0	25	46										G	220825429	C	G	220825429	3	3	105	1	0	0	0	0	1	0	0	0	9312	913	32	1	1731	1	MARK1	1	220825429	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	9073701	220825429	28425192	43	32190										
EXO1	9156	broad.mit.edu	37	chr1	242052811	242052811	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	taagaaacccctgtccccagTcagagataacatccaactaa	5	13	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:242052811T>G	uc001hzh.2	+	16	2990	c.2450T>G	c.(2449-2451)GTC>GGC	p.V817G	EXO1_uc001hzi.2_3'UTR|EXO1_uc001hzj.2_Missense_Mutation_p.V817G|EXO1_uc009xgq.2_Missense_Mutation_p.V816G	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	817	Interaction with MLH1.|Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			CTGTCCCCAGTCAGAGATAAC	0.373								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.012319	0	22	65										G	242052811	T	G	242052811	3	3	105	1	0	0	0	0	1	0	0	0	5300	1667	58	5	2500	5	EXO1	1	242052811	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	21227382	242052811	7197810	44	32191										
SCCPDH	51097	broad.mit.edu	37	chr1	246927628	246927628	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acagataagaacaaaccaaaTatcaaaatttgtactcaggt	5	7	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr1:246927628T>C	uc001ibr.2	+	10	1418	c.1071T>C	c.(1069-1071)AAT>AAC	p.N357N		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	357						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		ACAAACCAAATATCAAAATTT	0.383													0	0	0	0.013726	0	33	38										C	246927628	T	C	246927628	2	2	105	1	0	0	0	0	0	0	0	1	13885	1403	49	5		5	SCCPDH	1	246927628	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	4874817	246927628	2322993	45	32192										
YWHAQ	10971	broad.mit.edu	37	chr2	9728302	9728302	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacacatcttaccgttttagCcagcgtgcaggcaagctctg	9	13	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:9728302C>T	uc002qzw.2	-	3	738	c.574G>A	c.(574-576)GCT>ACT	p.A192T	YWHAQ_uc002qzx.2_Missense_Mutation_p.A192T	NM_006826	NP_006817	P27348	1433T_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	192					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		ACCGTTTTAGCCAGCGTGCAG	0.413													0	0	0	0.008361	0	30	19										T	9728302	C	T	9728302	3	4	105	1	0	0	0	0	1	0	0	0	17502	739	26	2	175	2	YWHAQ	2	9728302	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		9728302	233471071	46	32193										
GREB1	9687	broad.mit.edu	37	chr2	11772057	11772057	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccatgaatatataaaaagtcCgacattcactccaaccaccg	4	13	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:11772057C>T	uc002rbk.1	+	27	4934	c.4634C>T	c.(4633-4635)CCG>CTG	p.P1545L	GREB1_uc002rbp.1_Missense_Mutation_p.P543L	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1545						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		ATAAAAAGTCCGACATTCACT	0.343													0	0	0	0.016723	0	12	23										T	11772057	C	T	11772057	3	4	105	1	0	0	0	0	1	0	0	0	6760	652	23	2	4844	2	GREB1	2	11772057	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2043755	11772057	231427316	47	32194										
RAD51AP2	729475	broad.mit.edu	37	chr2	17697446	17697446	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aattttcattaatgtatcctCggttgttctgtataaattga	6	5	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:17697446C>T	uc002rcl.1	-	1	2261	c.2237G>A	c.(2236-2238)CGA>CAA	p.R746Q	RAD51AP2_uc010exn.1_Missense_Mutation_p.R737Q	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	746										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AATGTATCCTCGGTTGTTCTG	0.323													0	0	0	0.00623	0	40	15										T	17697446	C	T	17697446	3	4	105	1	0	0	0	0	1	0	0	0	12987	884	31	1	1254	1	RAD51AP2	2	17697446	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5925389	17697446	225501927	48	32195										
SDC1	6382	broad.mit.edu	37	chr2	20405117	20405117	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acctcacctgcacctgagccGgagaagttgtcagagtcatc	10	13	3	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:20405117G>T	uc002rdo.1	-	2	434	c.135C>A	c.(133-135)TCC>TCA	p.S45S	SDC1_uc002rdp.1_Silent_p.S45S|SDC1_uc010exv.2_Silent_p.S45S|SDC1_uc010exw.1_RNA	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	45	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CACCTGAGCCGGAGAAGTTGT	0.532													1	0	5.08636e-23	0.01441	5.5469e-23	62	30										T	20405117	G	T	20405117	2	4	105	1	0	0	0	0	0	0	0	1	13951	1103	39	4		4	SDC1	2	20405117	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2707671	20405117	222794256	49	32196										
REL	5966	broad.mit.edu	37	chr2	61149024	61149024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtcacatcatgcctcaatggCacctctgccttcttcaagct	6	15	6	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:61149024C>T	uc002sam.1	+	11	1438	c.1214C>T	c.(1213-1215)GCA>GTA	p.A405V	REL_uc002san.1_Missense_Mutation_p.A373V	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	405					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			GCCTCAATGGCACCTCTGCCT	0.507			A		Hodgkin Lymphoma								0	0	0	0.005443	0	26	67										T	61149024	C	T	61149024	3	4	105	1	0	0	0	0	1	0	0	0	13215	710	25	2	1256	2	REL	2	61149024	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	40743907	61149024	182050349	50	32197										
AFTPH	54812	broad.mit.edu	37	chr2	64779951	64779951	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagtggctcaactccaccttTtgttactggtactcaagatt	7	11	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:64779951T>C	uc002sdc.2	+	1	1375	c.1343T>C	c.(1342-1344)TTT>TCT	p.F448S	AFTPH_uc002scz.2_Missense_Mutation_p.F448S|AFTPH_uc002sda.2_Missense_Mutation_p.F448S|AFTPH_uc002sdb.2_Missense_Mutation_p.F448S	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	448					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						ACTCCACCTTTTGTTACTGGT	0.398													0	0	0	0.005524	0	40	135										C	64779951	T	C	64779951	3	2	105	1	0	0	0	0	1	0	0	0	364	1841	64	5	1345	5	AFTPH	2	64779951	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	3630927	64779951	178419422	51	32198										
ST3GAL5	8869	broad.mit.edu	37	chr2	86090551	86090551	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagctcgggtgtaccattgcAgggaaggcctcgagcaatca	14	10	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:86090551A>G	uc002sqq.1	-	2	269	c.140T>C	c.(139-141)CTG>CCG	p.L47P	ST3GAL5_uc010ysy.1_Missense_Mutation_p.L47P|ST3GAL5_uc010ysz.1_Missense_Mutation_p.L47P|ST3GAL5_uc010fgq.1_5'Flank|ST3GAL5_uc002sqp.1_Missense_Mutation_p.L24P	NM_003896	NP_003887	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	47	Cytoplasmic (Potential).				ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity				0						GTACCATTGCAGGGAAGGCCT	0.512													0	0	0	0.004007	0	15	56										G	86090551	A	G	86090551	3	3	105	1	0	0	0	0	1	0	0	0	15217	188	7	5	1140	5	ST3GAL5	2	86090551	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	21310600	86090551	157108822	52	32199										
VWA3B	200403	broad.mit.edu	37	chr2	98779342	98779342	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtcagagaggacgtgtttctCgtttggcaagagatggagga	16	5	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:98779342C>T	uc002syo.2	+	8	1281	c.1017C>T	c.(1015-1017)CTC>CTT	p.L339L	VWA3B_uc010yvh.1_Silent_p.L189L|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Silent_p.L339L|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_5'UTR	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	339										ovary(3)|large_intestine(2)|skin(1)	6						ACGTGTTTCTCGTTTGGCAAG	0.637													0	0	0	0.004656	0	26	17										T	98779342	C	T	98779342	2	4	105	1	0	0	0	0	0	0	0	1	17238	871	31	1		1	VWA3B	2	98779342	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	12688791	98779342	144420031	53	32200										
TTL	150465	broad.mit.edu	37	chr2	113258822	113258822	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctcagaggcttcagagcttcTcgatttcatagacaaccagg	9	11	4	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:113258822T>C	uc002thu.2	+	4	688	c.509T>C	c.(508-510)CTC>CCC	p.L170P	TTL_uc010fkm.1_5'Flank	NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	170	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		TCAGAGCTTCTCGATTTCATA	0.458			T	ETV6	ALL								0	0	0	0.008871	0	21	55										C	113258822	T	C	113258822	3	2	105	1	0	0	0	0	1	0	0	0	16718	1551	54	5	523	5	TTL	2	113258822	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	14479480	113258822	129940551	54	32201										
SCTR	6344	broad.mit.edu	37	chr2	120221747	120221747	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctgaggagaagagcacggcGtccttgatgaagttggacag	15	7	1	5			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:120221747G>A	uc002tma.2	-	6	814	c.588C>T	c.(586-588)GAC>GAT	p.D196D	SCTR_uc002tlz.2_Silent_p.D18D	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	196	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity	p.D196N(1)		ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGAGCACGGCGTCCTTGATGA	0.582													0	0	0	0.00499	0	18	61										A	120221747	G	A	120221747	2	1	105	1	0	0	0	0	0	0	0	1	13943	1136	40	2		2	SCTR	2	120221747	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6962925	120221747	122977626	55	32202										
PROC	5624	broad.mit.edu	37	chr2	128185988	128185988	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctggacctggacatcaaggaGgtcttcgtccaccccaacta	9	14	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:128185988G>A	uc002tok.2	+	9	925	c.852G>A	c.(850-852)GAG>GAA	p.E284E	PROC_uc002tol.2_Silent_p.E305E|PROC_uc010yzi.1_Silent_p.E340E|PROC_uc010yzj.1_Silent_p.E179E|PROC_uc010yzk.1_Silent_p.E339E|PROC_uc002tom.2_Silent_p.E318E	NM_000312	NP_000303	P04070	PROC_HUMAN	protein C	284	Peptidase S1.				blood coagulation|leukocyte migration|negative regulation of apoptosis|negative regulation of blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|protein binding|serine-type endopeptidase activity				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0673)	Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)|Sodium Tetradecyl Sulfate(DB00464)	ACATCAAGGAGGTCTTCGTCC	0.632													0	0	0	0.00632	0	30	34										A	128185988	G	A	128185988	2	1	105	1	0	0	0	0	0	0	0	1	12545	991	35	2		2	PROC	2	128185988	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7964241	128185988	115013385	56	32203										
MYO7B	4648	broad.mit.edu	37	chr2	128324290	128324290	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctacaccctggagcaggtaCagctctactacagccgccat	8	15	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:128324290C>T	uc002top.2	+	5	411	c.358C>T	c.(358-360)CAG>TAG	p.Q120*		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	120	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GGAGCAGGTACAGCTCTACTA	0.592													0	0	0	0.009096	0	4	17										T	128324290	C	T	128324290	4	4	105	1	0	0	0	0	0	1	0	0	10083	479	17	2	372	2	MYO7B	2	128324290	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	138302	128324290	114875083	57	32204										
LIMS2	55679	broad.mit.edu	37	chr2	128399647	128399647	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacgtgccactgcttgcccaGcgcgttgaccactcggccct	10	18	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:128399647G>A	uc002tpa.2	-	6	803	c.637C>T	c.(637-639)CTG>TTG	p.L213L	LIMS2_uc002tou.2_Silent_p.L21L|LIMS2_uc002tov.2_Silent_p.L61L|LIMS2_uc002tow.2_Silent_p.L61L|LIMS2_uc002tox.2_Silent_p.L237L|LIMS2_uc010fmb.2_Silent_p.L123L|LIMS2_uc002toy.2_Silent_p.L208L|LIMS2_uc010yzm.1_Silent_p.L235L|LIMS2_uc002toz.2_Silent_p.L208L|LIMS2_uc002tpb.2_Silent_p.L208L	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	213	LIM zinc-binding 4.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		TGCTTGCCCAGCGCGTTGACC	0.667													0	0	0	0.004672	0	3	12										A	128399647	G	A	128399647	2	1	105	1	0	0	0	0	0	0	0	1	8804	962	34	2		2	LIMS2	2	128399647	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	75357	128399647	114799726	58	32205										
SAP130	79595	broad.mit.edu	37	chr2	128699689	128699689	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaaccttaagcatggagtctCtggcttcactgatttgatcc	8	10	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:128699689C>G	uc002tpp.2	-	20	3170	c.3038G>C	c.(3037-3039)AGA>ACA	p.R1013T	SAP130_uc002tpn.2_Missense_Mutation_p.R773T|SAP130_uc002tpo.2_Missense_Mutation_p.R793T|SAP130_uc010fmd.2_Missense_Mutation_p.R1048T	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	1013	Interactions with SIN3A and HDAC1.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CATGGAGTCTCTGGCTTCACT	0.413													0	0	0	0.007291	0	31	71										G	128699689	C	G	128699689	3	3	105	1	0	0	0	0	1	0	0	0	13831	913	32	1	112	1	SAP130	2	128699689	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	300042	128699689	114499684	59	32206										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135922214	135922214	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtgttagtcaccggtgcagGaagaggacatgctggcagga	16	7	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:135922214G>A	uc002tuj.2	+	23	2682	c.2657G>A	c.(2656-2658)GGA>GAA	p.G886E	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.G886E|RAB3GAP1_uc010fng.2_Missense_Mutation_p.G711E|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	886						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		ACCGGTGCAGGAAGAGGACAT	0.498													0	0	0	0.006214	0	10	22										A	135922214	G	A	135922214	3	1	105	1	0	0	0	0	1	0	0	0	12935	1174	41	1	2747	1	RAB3GAP1	2	135922214	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7222525	135922214	107277159	60	32207										
LYPD6B	130576	broad.mit.edu	37	chr2	150061768	150061768	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtgtgtcttttcaccatagaTataagagttcggaccgccca	9	10	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:150061768T>C	uc002twv.1	+	4	480	c.79T>C	c.(79-81)TAT>CAT	p.Y27H	LYPD6B_uc002tww.1_5'UTR|LYPD6B_uc002twx.1_5'UTR	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	3						anchored to membrane|plasma membrane					0						TCACCATAGATATAAGAGTTC	0.433													0	0	0	0.01441	0	52	43										C	150061768	T	C	150061768	3	2	105	1	0	0	0	0	1	0	0	0	9115	1420	49	5	89	5	LYPD6B	2	150061768	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	14139554	150061768	93137605	61	32208										
LRP2	4036	broad.mit.edu	37	chr2	170151164	170151164	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aactttccaatcacacttctGactggtgttatagcaggccc	7	12	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:170151164G>C	uc002ues.2	-	5	697	c.484C>G	c.(484-486)CAG>GAG	p.Q162E	LRP2_uc010zdf.1_Missense_Mutation_p.Q162E	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	162	LDL-receptor class A 4.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCACACTTCTGACTGGTGTTA	0.318													0	0	0	0.004656	0	25	25										C	170151164	G	C	170151164	3	2	105	1	0	0	0	0	1	0	0	0	8956	1299	45	1	13783	1	LRP2	2	170151164	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	20089396	170151164	73048209	62	32209										
GPR155	151556	broad.mit.edu	37	chr2	175304649	175304649	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctttctttgacaatgtttcgGatacagaggtcacggtgata	10	7	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:175304649G>A	uc002uit.2	-	16	2680	c.2289C>T	c.(2287-2289)ATC>ATT	p.I763I	GPR155_uc002uiu.2_Silent_p.I763I|GPR155_uc002uiv.2_Silent_p.I763I|GPR155_uc010fqs.2_Silent_p.I735I	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	763	DEP.				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						CAATGTTTCGGATACAGAGGT	0.343													0	0	0	0.007413	0	17	77										A	175304649	G	A	175304649	2	1	105	1	0	0	0	0	0	0	0	1	6660	1164	41	1		1	GPR155	2	175304649	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	5153485	175304649	67894724	63	32210										
TTN	7273	broad.mit.edu	37	chr2	179587113	179587113	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gccacattatctacaaatgaAgtctgtagattttcatcgtc	6	9	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:179587113A>G	uc010zfg.1	-	74	18893	c.18669T>C	c.(18667-18669)ACT>ACC	p.T6223T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T2884T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7150							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTACAAATGAAGTCTGTAGAT	0.413													0	0	0	0.012213	0	35	24										G	179587113	A	G	179587113	2	3	105	1	0	0	0	0	0	0	0	1	16732	59	3	5		5	TTN	2	179587113	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	4282464	179587113	63612260	64	32211										
PIKFYVE	200576	broad.mit.edu	37	chr2	209142384	209142384	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tatgtgggcagattttctgcAgtcgttgctgtaatcaagaa	11	6	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:209142384A>T	uc002vcz.2	+	5	723	c.565A>T	c.(565-567)AGT>TGT	p.S189C	PIKFYVE_uc010fun.1_Intron|PIKFYVE_uc002vcy.1_Missense_Mutation_p.S189C|PIKFYVE_uc002vcv.2_Intron|PIKFYVE_uc002vcw.2_Missense_Mutation_p.S189C|PIKFYVE_uc002vcx.2_Intron	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	189	FYVE-type.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GATTTTCTGCAGTCGTTGCTG	0.383													0	0	0	0.009535	0	27	107										T	209142384	A	T	209142384	3	4	105	1	0	0	0	0	1	0	0	0	11924	188	7	5	579	5	PIKFYVE	2	209142384	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	29555271	209142384	34056989	65	32212										
TNS1	7145	broad.mit.edu	37	chr2	218712961	218712961	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctcccggctgcttccccctCggaccggagctgggggcagc	14	18	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:218712961C>T	uc002vgt.2	-	17	2302	c.1904G>A	c.(1903-1905)CGA>CAA	p.R635Q	TNS1_uc002vgr.2_Missense_Mutation_p.R635Q|TNS1_uc002vgs.2_Missense_Mutation_p.R635Q|TNS1_uc010zjv.1_Missense_Mutation_p.R635Q|TNS1_uc010fvj.1_Missense_Mutation_p.R703Q|TNS1_uc010fvk.1_Missense_Mutation_p.R760Q|TNS1_uc010fvi.1_Missense_Mutation_p.R322Q	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	635						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCTTCCCCCTCGGACCGGAGC	0.542													0	0	0	0.001168	0	6	59										T	218712961	C	T	218712961	3	4	105	1	0	0	0	0	1	0	0	0	16340	884	31	1	3371	1	TNS1	2	218712961	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	9570577	218712961	24486412	66	32213										
OBSL1	23363	broad.mit.edu	37	chr2	220434968	220434968	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acgtgcagctgcacggcactGagcgtctggcccgccgagtt	14	14	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:220434968G>A	uc010fwk.2	-	1	1044	c.987C>T	c.(985-987)CTC>CTT	p.L329L	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Silent_p.L329L|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	329	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		GCACGGCACTGAGCGTCTGGC	0.692													0	0	0	0.00308	0	8	8										A	220434968	G	A	220434968	2	1	105	1	0	0	0	0	0	0	0	1	10813	1277	45	1		1	OBSL1	2	220434968	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1722007	220434968	22764405	67	32214										
ATG16L1	55054	broad.mit.edu	37	chr2	234198934	234198934	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggatccagttgcaatgatatTgtctgcacagagcaatgtgt	11	7	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:234198934T>C	uc002vty.2	+	14	1622	c.1365T>C	c.(1363-1365)ATT>ATC	p.I455I	ATG16L1_uc002vtx.1_Silent_p.I292I|ATG16L1_uc002vua.2_Silent_p.I436I|ATG16L1_uc002vub.2_Silent_p.I313I|ATG16L1_uc002vtz.2_Silent_p.I276I|ATG16L1_uc002vud.3_Silent_p.I371I	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	455	WD 4.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GCAATGATATTGTCTGCACAG	0.413													0	0	0	0.00623	0	37	68										C	234198934	T	C	234198934	2	2	105	1	0	0	0	0	0	0	0	1	1091	1800	63	5		5	ATG16L1	2	234198934	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	13763966	234198934	9000439	68	32215										
UGT1A10	54575	broad.mit.edu	37	chr2	234545483	234545483	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaagcacaggcacaaagtatAttttctctattaatgagttc	6	7	1	1	rs45580232		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr2:234545483A>C	uc002vur.2	+	1	361	c.315A>C	c.(313-315)ATA>ATC	p.I105I	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Silent_p.I105I	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	105					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		CACAAAGTATATTTTCTCTAT	0.388													0	0	0	0.006122	0	19	73										C	234545483	A	C	234545483	2	2	105	1	0	0	0	0	0	0	0	1	16942	439	16	5		5	UGT1A10	2	234545483	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	346549	234545483	8653890	69	32216										
ITPR1	3708	broad.mit.edu	37	chr3	4730215	4730215	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcaagagataatgaggttgGctcatgaatttttgcagaat	11	4	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:4730215G>A	uc003bqa.2	+	31	4060	c.3712G>A	c.(3712-3714)GCT>ACT	p.A1238T	ITPR1_uc010hca.1_Missense_Mutation_p.A1223T|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.A169T	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1247	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AATGAGGTTGGCTCATGAATT	0.468													0	0	0	0.008361	0	30	106										A	4730215	G	A	4730215	3	1	105	1	0	0	0	0	1	0	0	0	7920	1203	42	2	3853	2	ITPR1	3	4730215	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		4730215	193292215	70	32217										
LMCD1	29995	broad.mit.edu	37	chr3	8607273	8607273	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tacttctggaaggatggtgcAccctggtgcggccgccatta	13	11	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:8607273A>C	uc003bqq.2	+	5	993	c.879A>C	c.(877-879)GCA>GCC	p.A293A	LMCD1_uc011atd.1_Silent_p.A220A|LMCD1_uc011ate.1_Silent_p.A181A	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	293	LIM zinc-binding 1.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AGGATGGTGCACCCTGGTGCG	0.632													0	0	0	0.008291	0	7	18										C	8607273	A	C	8607273	2	2	105	1	0	0	0	0	0	0	0	1	8844	146	6	5		5	LMCD1	3	8607273	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	3877058	8607273	189415157	71	32218										
OXTR	5021	broad.mit.edu	37	chr3	8809375	8809375	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtgcacctgcggcgcgctggCcaccaggcagccgagccacg	15	17	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:8809375C>T	uc003brc.2	-	3	1121	c.499G>A	c.(499-501)GCC>ACC	p.A167T		NM_000916	NP_000907	P30559	OXYR_HUMAN	oxytocin receptor	167	Helical; Name=4; (Potential).				female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GGCGCGCTGGCCACCAGGCAG	0.716													0	0	0	0.012319	0	21	12										T	8809375	C	T	8809375	3	4	105	1	0	0	0	0	1	0	0	0	11338	739	26	2	678	2	OXTR	3	8809375	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	202102	8809375	189213055	72	32219										
BRPF1	7862	broad.mit.edu	37	chr3	9785587	9785587	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agccaggagacaagcaaaggTctgaatcccatggcaaggtg	13	9	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:9785587T>C	uc003bse.2	+	8	3016	c.2617_splice	c.e8+2	p.G873_splice	BRPF1_uc003bsf.2_Splice_Site_p.G879_splice|BRPF1_uc003bsg.2_Splice_Site_p.G872_splice|BRPF1_uc011ati.1_Splice_Site_p.D873_splice	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1						histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					CAAGCAAAGGTCTGAATCCCA	0.602													0	0	0	0.003163	0	15	20										C	9785587	T	C	9785587	5	2	105	1	0	0	0	0	0	0	1	0	1520	1681	58	5	2663	5	BRPF1	3	9785587	Splice_Site	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	976212	9785587	188236843	73	32220										
CRELD1	78987	broad.mit.edu	37	chr3	9976525	9976525	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttttctgtttccagggcctgGagagaaccatccgggacaac	11	11	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:9976525G>C	uc003bug.2	+	3	299	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.E61Q|CRELD1_uc003buh.2_Missense_Mutation_p.E61Q|CRELD1_uc003bui.2_Missense_Mutation_p.E61Q|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	61	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						CCAGGGCCTGGAGAGAACCAT	0.363													0	0	0	0.001984	0	7	15										C	9976525	G	C	9976525	3	2	105	1	0	0	0	0	1	0	0	0	3866	1175	41	1	187	1	CRELD1	3	9976525	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	190938	9976525	188045905	74	32221										
FANCD2	2177	broad.mit.edu	37	chr3	10106445	10106445	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcctgtgaaagcactgtacgGactggaagaatacgacactc	10	10	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:10106445G>C	uc003buw.2	+	23	2132	c.2054G>C	c.(2053-2055)GGA>GCA	p.G685A	FANCD2_uc003bux.1_Missense_Mutation_p.G685A|FANCD2_uc003buy.1_Missense_Mutation_p.G685A|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	685					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GCACTGTACGGACTGGAAGAA	0.498			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007291	0	28	97										C	10106445	G	C	10106445	3	2	105	1	0	0	0	0	1	0	0	0	5665	1174	41	1	2140	1	FANCD2	3	10106445	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	129920	10106445	187915985	75	32222										
FANCD2	2177	broad.mit.edu	37	chr3	10107147	10107147	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgtgtggagagacagcataaCggaaacttggaggagattga	15	4	0	3	rs35817402		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:10107147C>A	uc003buw.2	+	24	2316	c.2238C>A	c.(2236-2238)AAC>AAA	p.N746K	FANCD2_uc003bux.1_Missense_Mutation_p.N746K|FANCD2_uc003buy.1_Missense_Mutation_p.N746K|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	746					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GACAGCATAACGGAAACTTGG	0.443			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	2.35188e-11	0.006122	2.48e-11	18	63										A	10107147	C	A	10107147	3	1	105	1	0	0	0	0	1	0	0	0	5665	535	19	4	2328	4	FANCD2	3	10107147	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	702	10107147	187915283	76	32223										
ATP2B2	491	broad.mit.edu	37	chr3	10400558	10400558	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttaccatctcgtcccggtcGcggggccggaagacacgagg	14	13	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:10400558G>A	uc003bvt.2	-	14	2392	c.1953C>T	c.(1951-1953)CGC>CGT	p.R651R	ATP2B2_uc003bvv.2_Silent_p.R606R|ATP2B2_uc003bvw.2_Silent_p.R606R|ATP2B2_uc010hdo.2_Silent_p.R356R	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	651	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGTCCCGGTCGCGGGGCCGGA	0.632													0	0	0	0.013537	0	12	34										A	10400558	G	A	10400558	2	1	105	1	0	0	0	0	0	0	0	1	1140	1074	38	2		2	ATP2B2	3	10400558	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	293411	10400558	187621872	77	32224										
WNT7A	7476	broad.mit.edu	37	chr3	13916528	13916528	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcggaactgaaactgacactCgtccaggcccatttgtgagc	11	12	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:13916528C>T	uc003bye.1	-	2	519	c.214G>A	c.(214-216)GAG>AAG	p.E72K		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	72			E -> K (in LPHAS).		activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						AACTGACACTCGTCCAGGCCC	0.597													0	0	0	0.00499	0	18	35										T	13916528	C	T	13916528	3	4	105	1	0	0	0	0	1	0	0	0	17391	893	31	1	847	1	WNT7A	3	13916528	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3515970	13916528	184105902	78	32225										
TOP2B	7155	broad.mit.edu	37	chr3	25639947	25639947	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtccacatctgaatcctgatCaaaagatgtcttcttcggtt	7	10	4	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:25639947C>T	uc003cdj.2	-	36	4717	c.4717G>A	c.(4717-4719)GAT>AAT	p.D1573N	TOP2B_uc011awm.1_Missense_Mutation_p.D430N|TOP2B_uc010hff.1_Missense_Mutation_p.D439N	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	1578					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GAATCCTGATCAAAAGATGTC	0.383													0	0	0	0.006122	0	19	15										T	25639947	C	T	25639947	3	4	105	1	0	0	0	0	1	0	0	0	16363	826	29	1	152	1	TOP2B	3	25639947	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	11723419	25639947	172382483	79	32226										
ZCWPW2	152098	broad.mit.edu	37	chr3	28562512	28562512	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agacggaagttttactaaaaGagctggagcaaatgctgcag	12	6	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:28562512G>A	uc003ceh.2	+	9	982	c.814G>A	c.(814-816)GAG>AAG	p.E272K	ZCWPW2_uc003cei.2_Missense_Mutation_p.E272K|ZCWPW2_uc010hfo.2_Missense_Mutation_p.E77K	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	272							zinc ion binding			ovary(2)	2						TTTACTAAAAGAGCTGGAGCA	0.368													0	0	0	0.00308	0	8	32										A	28562512	G	A	28562512	3	1	105	1	0	0	0	0	1	0	0	0	17595	943	33	1	840	1	ZCWPW2	3	28562512	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2922565	28562512	169459918	80	32227										
DALRD3	55152	broad.mit.edu	37	chr3	49053759	49053759	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtggagatactgctgtcagcCagagccaggaagagctgggg	17	8	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:49053759C>G	uc003cvk.1	-	9	1181	c.1161G>C	c.(1159-1161)CTG>CTC	p.L387L	DALRD3_uc003cvl.1_Silent_p.L387L|DALRD3_uc003cvm.1_Silent_p.L220L|DALRD3_uc010hko.1_Silent_p.L220L|DALRD3_uc011bca.1_Silent_p.L387L	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	387					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGCTGTCAGCCAGAGCCAGGA	0.547													0	0	0	0.004672	0	3	28										G	49053759	C	G	49053759	2	3	105	1	0	0	0	0	0	0	0	1	4229	581	21	4		4	DALRD3	3	49053759	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	20491247	49053759	148968671	81	32228										
DUSP7	1849	broad.mit.edu	37	chr3	52089928	52089928	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtaggagcaggccgagcacgGaggcgggagcgccgggctcg	21	11	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:52089928G>C	uc003dct.2	-	1	534	c.455C>G	c.(454-456)TCC>TGC	p.S152C	DUSP7_uc010hma.2_Missense_Mutation_p.S152C	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	152	Rhodanese.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCCGAGCACGGAGGCGGGAGC	0.721													0	0	0	0.004672	0	3	4										C	52089928	G	C	52089928	3	2	105	1	0	0	0	0	1	0	0	0	4830	1174	41	1	816	1	DUSP7	3	52089928	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3036169	52089928	145932502	82	32229										
PBRM1	55193	broad.mit.edu	37	chr3	52598157	52598157	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catctgcttgtcgctctcatTgtagcggctctcacaaagca	8	13	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:52598157T>C	uc003des.2	-	23	3796	c.3784A>G	c.(3784-3786)AAT>GAT	p.N1262D	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.N1262D|PBRM1_uc003der.2_Missense_Mutation_p.N1230D|PBRM1_uc003det.2_Missense_Mutation_p.N1277D|PBRM1_uc003deu.2_Missense_Mutation_p.N1277D|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.N1262D|PBRM1_uc010hmk.1_Missense_Mutation_p.N1237D|PBRM1_uc003dey.2_Missense_Mutation_p.N1237D|PBRM1_uc003dez.1_Missense_Mutation_p.N1261D	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1262	BAH 2.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TCGCTCTCATTGTAGCGGCTC	0.413			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.010818	0	34	28										C	52598157	T	C	52598157	3	2	105	1	0	0	0	0	1	0	0	0	11491	1812	63	5	1148	5	PBRM1	3	52598157	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	508229	52598157	145424273	83	32230										
DCP1A	55802	broad.mit.edu	37	chr3	53346282	53346282	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagcctcaccctctcatactCatccttggctctgctcagca	6	17	5	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:53346282C>T	uc003dgs.3	-	5	592	c.499G>A	c.(499-501)GAG>AAG	p.E167K	DCP1A_uc003dgt.3_RNA	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A	167					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		CTCTCATACTCATCCTTGGCT	0.577													0	0	0	0.008871	0	19	24										T	53346282	C	T	53346282	3	4	105	1	0	0	0	0	1	0	0	0	4298	835	29	1	1273	1	DCP1A	3	53346282	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	748125	53346282	144676148	84	32231										
CACNA2D3	55799	broad.mit.edu	37	chr3	54925415	54925415	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggcgtggaggttgccttcctCggcactcgcacgggcctctc	14	15	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:54925415C>T	uc003dhf.2	+	25	2232	c.2184C>T	c.(2182-2184)CTC>CTT	p.L728L	CACNA2D3_uc003dhg.1_Silent_p.L634L|CACNA2D3_uc003dhh.1_RNA|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	728	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTGCCTTCCTCGGCACTCGCA	0.532													0	0	0	0.012319	0	20	30										T	54925415	C	T	54925415	2	4	105	1	0	0	0	0	0	0	0	1	2550	871	31	1		1	CACNA2D3	3	54925415	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1579133	54925415	143097015	85	32232										
CCDC66	285331	broad.mit.edu	37	chr3	56598036	56598036	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acaaaaaacacatcacagctGaaaacatgaagagcagtttg	7	8	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:56598036G>A	uc003dhz.2	+	4	514	c.427G>A	c.(427-429)GAA>AAA	p.E143K	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Missense_Mutation_p.E109K|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dhv.2_RNA|CCDC66_uc003dhw.2_Missense_Mutation_p.E143K	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	143										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		CATCACAGCTGAAAACATGAA	0.393													0	0	0	0.01892	0	23	29										A	56598036	G	A	56598036	3	1	105	1	0	0	0	0	1	0	0	0	2838	1291	45	1	441	1	CCDC66	3	56598036	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1672621	56598036	141424394	86	32233										
PDE12	201626	broad.mit.edu	37	chr3	57542432	57542432	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tagcggcggtgcggcctgttCagggccggggcctgagccgg	20	12	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:57542432C>T	uc003diw.3	+	1	452	c.326C>T	c.(325-327)TCA>TTA	p.S109L	PDE12_uc003div.2_Missense_Mutation_p.S109L	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	109							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GCGGCCTGTTCAGGGCCGGGG	0.657													0	0	0	0.008871	0	20	12										T	57542432	C	T	57542432	3	4	105	1	0	0	0	0	1	0	0	0	11632	838	29	1	328	1	PDE12	3	57542432	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	944396	57542432	140479998	87	32234										
PXK	54899	broad.mit.edu	37	chr3	58368279	58368279	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctcttcctcccaaaaaattGattggtaacatggatcgtga	7	10	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:58368279G>C	uc003djz.1	+	4	339	c.240G>C	c.(238-240)TTG>TTC	p.L80F	PXK_uc003djx.1_Missense_Mutation_p.L80F|PXK_uc003djy.1_Missense_Mutation_p.L63F|PXK_uc003dka.1_Missense_Mutation_p.L80F|PXK_uc003dkb.1_5'UTR|PXK_uc003dkc.1_Missense_Mutation_p.L63F|PXK_uc011bfe.1_Missense_Mutation_p.L47F|PXK_uc010hnj.1_Missense_Mutation_p.L47F|PXK_uc003dkd.1_Intron|PXK_uc010hnk.1_5'UTR	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	80	PX.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		CCAAAAAATTGATTGGTAACA	0.343													0	0	0	0.004482	0	6	48										C	58368279	G	C	58368279	3	2	105	1	0	0	0	0	1	0	0	0	12849	1281	45	1	254	1	PXK	3	58368279	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	825847	58368279	139654151	88	32235										
GXYLT2	727936	broad.mit.edu	37	chr3	72957678	72957678	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tccaattccacatcttcactGaagactctctgaagcccgag	6	14	3	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:72957678G>A	uc003dpg.2	+	2	436	c.436G>A	c.(436-438)GAA>AAA	p.E146K		NM_001080393	NP_001073862	A0PJZ3	GXLT2_HUMAN	glycosyltransferase 8 domain containing 4	146	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						CATCTTCACTGAAGACTCTCT	0.463													0	0	0	0.012213	0	29	29										A	72957678	G	A	72957678	3	1	105	1	0	0	0	0	1	0	0	0	6904	1291	45	1	442	1	GXYLT2	3	72957678	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	14589399	72957678	125064752	89	32236										
HTR1F	3355	broad.mit.edu	37	chr3	88040157	88040157	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agcattgtgtatattgtgagAgagagctggattatggggca	15	3	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:88040157A>G	uc003dqr.2	+	2	416	c.258A>G	c.(256-258)AGA>AGG	p.R86R		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	86	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	ATATTGTGAGAGAGAGCTGGA	0.468													0	0	0	0.014758	0	5	79										G	88040157	A	G	88040157	2	3	105	1	0	0	0	0	0	0	0	1	7440	301	11	5		5	HTR1F	3	88040157	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	15082479	88040157	109982273	90	32237										
OR5H15	403274	broad.mit.edu	37	chr3	97887646	97887646	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcttggcattcttggtaataTatctcatcaccatcatgggg	8	9	5	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:97887646T>G	uc011bgu.1	+	1	103	c.103T>G	c.(103-105)TAT>GAT	p.Y35D		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTGGTAATATATCTCATCAC	0.408													0	0	0	0.01441	0	135	141										G	97887646	T	G	97887646	3	3	105	1	0	0	0	0	1	0	0	0	11161	1406	49	5	105	5	OR5H15	3	97887646	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	9847489	97887646	100134784	91	32238										
DRD3	1814	broad.mit.edu	37	chr3	113847578	113847578	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctccctcagcaagacaggatCttgaggaaggctttccggaa	11	11	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:113847578C>G	uc003ebd.2	-	8	1611	c.1188G>C	c.(1186-1188)AAG>AAC	p.K396N	DRD3_uc010hqn.1_Missense_Mutation_p.K396N|DRD3_uc003ebb.1_Missense_Mutation_p.K363N|DRD3_uc003ebc.1_Missense_Mutation_p.K396N	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	396	Cytoplasmic.			K -> L (in Ref. 7; AAH95510).	activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AAGACAGGATCTTGAGGAAGG	0.527													0	0	0	0.01441	0	95	169										G	113847578	C	G	113847578	3	3	105	1	0	0	0	0	1	0	0	0	4758	912	32	1	18	1	DRD3	3	113847578	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	15959932	113847578	84174852	92	32239										
CASR	846	broad.mit.edu	37	chr3	122003997	122003997	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacagagctttgtcatcagtGgtggaggcagcactgttaca	12	9	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:122003997G>C	uc003eev.3	+	7	3568	c.3196G>C	c.(3196-3198)GGT>CGT	p.G1066R	CASR_uc003eew.3_Missense_Mutation_p.G1076R	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	1066	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TGTCATCAGTGGTGGAGGCAG	0.532													0	0	0	0.016522	0	23	51										C	122003997	G	C	122003997	3	2	105	1	0	0	0	0	1	0	0	0	2682	1348	47	4	3248	4	CASR	3	122003997	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	8156419	122003997	76018433	93	32240										
DNAJC13	23317	broad.mit.edu	37	chr3	132169586	132169586	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaccaaattaatcctgcaacCaacagagtactctgttccta	5	12	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:132169586C>G	uc003eor.2	+	6	497	c.432C>G	c.(430-432)ACC>ACG	p.T144T	DNAJC13_uc010htq.1_Silent_p.T144T	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	144							heat shock protein binding			ovary(1)|breast(1)	2						ATCCTGCAACCAACAGAGTAC	0.358													0	0	0	0.012319	0	21	32										G	132169586	C	G	132169586	2	3	105	1	0	0	0	0	0	0	0	1	4632	581	21	4		4	DNAJC13	3	132169586	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10165589	132169586	65852844	94	32241										
SMC4	10051	broad.mit.edu	37	chr3	160137191	160137191	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacaagaagaaacaaactttAaaagtttggttcatgatctc	6	7	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:160137191A>G	uc003fdh.2	+	12	1830	c.1717A>G	c.(1717-1719)AAA>GAA	p.K573E	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Missense_Mutation_p.K337E|SMC4_uc003fdi.2_Missense_Mutation_p.K548E|SMC4_uc003fdj.2_Missense_Mutation_p.K573E|SMC4_uc010hwd.2_Missense_Mutation_p.K573E|SMC4_uc003fdl.2_Missense_Mutation_p.K276E	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	573	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AACAAACTTTAAAAGTTTGGT	0.308													0	0	0	0.014323	0	23	55										G	160137191	A	G	160137191	3	3	105	1	0	0	0	0	1	0	0	0	14785	363	13	5	1759	5	SMC4	3	160137191	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	27967605	160137191	37885239	95	32242										
TRA2B	6434	broad.mit.edu	37	chr3	185638917	185638917	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgatctgctatagtagtcccGatcatcatagccccgatcat	7	12	4	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:185638917G>A	uc003fpv.2	-	6	973	c.697C>T	c.(697-699)CGG>TGG	p.R233W	TRA2B_uc003fpt.2_RNA|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Missense_Mutation_p.R133W|TRA2B_uc003fpw.2_Missense_Mutation_p.R233W	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	233	Arg/Ser-rich (RS2 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						TAGTAGTCCCGATCATCATAG	0.428													0	0	0	0.01441	0	53	39										A	185638917	G	A	185638917	3	1	105	1	0	0	0	0	1	0	0	0	16431	1057	37	1	185	1	TRA2B	3	185638917	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	25501726	185638917	12383513	96	32243										
TMEM44	93109	broad.mit.edu	37	chr3	194344402	194344402	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gccctgagctgccgcctcctCttcctctctcgggcttcccg	9	20	2	1	rs143204807		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:194344402C>G	uc010hzn.2	-	4	550	c.381G>C	c.(379-381)AAG>AAC	p.K127N	TMEM44_uc003fue.2_Missense_Mutation_p.K127N|TMEM44_uc003fud.2_Missense_Mutation_p.K127N|TMEM44_uc003fuf.2_Missense_Mutation_p.K127N|TMEM44_uc011bsv.1_Missense_Mutation_p.K127N|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	127	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		GCCGCCTCCTCTTCCTCTCTC	0.617													0	0	0	0.006214	0	10	39										G	194344402	C	G	194344402	3	3	105	1	0	0	0	0	1	0	0	0	16165	912	32	1	1112	1	TMEM44	3	194344402	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	8705485	194344402	3678028	97	32244										
MUC4	4585	broad.mit.edu	37	chr3	195517279	195517279	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttggcattctgaacacctttGatgttaccaggaatgtattg	9	7	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr3:195517279G>A	uc011bto.1	-	2	1632	c.1172C>T	c.(1171-1173)TCA>TTA	p.S391L	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.S273L	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	396					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAACACCTTTGATGTTACCAG	0.453													0	0	0	0.01441	0	104	86										A	195517279	G	A	195517279	3	1	105	1	0	0	0	0	1	0	0	0	9978	1294	45	1		1	MUC4	3	195517279	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1172877	195517279	2505151	98	32245										
TACC3	10460	broad.mit.edu	37	chr4	1739043	1739043	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagttcgatttcttgggagcActggacattcctgtaagtcc	11	9	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:1739043A>G	uc003gdo.2	+	9	1932	c.1824A>G	c.(1822-1824)GCA>GCG	p.A608A	TACC3_uc010ibz.2_Silent_p.A608A|TACC3_uc003gdp.2_Silent_p.A248A|TACC3_uc010ica.2_Silent_p.A25A	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	608						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			TCTTGGGAGCACTGGACATTC	0.527													0	0	0	0.00308	0	7	24										G	1739043	A	G	1739043	2	3	105	1	0	0	0	0	0	0	0	1	15500	146	6	5		5	TACC3	4	1739043	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08		1739043	189415233	99	32246										
ZFYVE28	57732	broad.mit.edu	37	chr4	2273431	2273439	+	In_Frame_Del	DEL	GCCAGTTCA	GCCAGTTCA	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccccatcgcgggtcttggctGccagttcagaggatgacagg							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:2273431_2273439delGCCAGTTCA	uc003gex.1	-	11	2710_2718	c.2391_2399delTGAACTGGC	c.(2389-2400)TCTGAACTGGCA>TCA	p.ELA798del	ZFYVE28_uc011bvk.1_In_Frame_Del_p.ELA728del|ZFYVE28_uc011bvl.1_In_Frame_Del_p.ELA768del|ZFYVE28_uc003gew.1_In_Frame_Del_p.ELA684del	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	798_800					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GGTCTTGGCTGCCAGTTCAGAGGATGACA	0.627																		40	128	---	---								-	2273439	GCCAGTTCA	-	2273431	7	5	105	1	0	1	0	1	0	0	0	0	17667	1319	46	0	276	0	ZFYVE28	4	2273431	In_Frame_Del	DEL	GCCAGTTCA	TCGA-GC-A3RC-01A-11D-A22Z-08	534388	2273431	188880845	100	32247										
HTT	3064	broad.mit.edu	37	chr4	3182340	3182340	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgaaacccaaaaagaggtgGtggtgtcaatgttactgaga	12	5	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:3182340G>T	uc011bvq.1	+	37	4862	c.4717G>T	c.(4717-4719)GTG>TTG	p.V1573L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1571					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		AAAAGAGGTGGTGGTGTCAAT	0.453													1	0	1.61788e-16	0.012213	1.71939e-16	35	34										T	3182340	G	T	3182340	3	4	105	1	0	0	0	0	1	0	0	0	7457	1261	44	4	4853	4	HTT	4	3182340	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	908909	3182340	187971936	101	32248										
ZBTB49	166793	broad.mit.edu	37	chr4	4301680	4301680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgaatggttgagcatggaccCtgttgctacccacagctgcc	11	12	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:4301680C>T	uc003ghu.2	+	2	183	c.8C>T	c.(7-9)CCT>CTT	p.P3L	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						AGCATGGACCCTGTTGCTACC	0.468													0	0	0	0.009718	0	43	55										T	4301680	C	T	4301680	3	4	105	1	0	0	0	0	1	0	0	0	17547	681	24	2	10	2	ZBTB49	4	4301680	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1119340	4301680	186852596	102	32249										
TBC1D14	57533	broad.mit.edu	37	chr4	6969151	6969151	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gattcaaagagaatacagaaGgtacacaagatacaaaatca	7	6	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:6969151G>A	uc011bwg.1	+	3	922	c.843G>A	c.(841-843)AAG>AAA	p.K281K	TBC1D14_uc003gjs.3_Silent_p.K281K	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	281						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						GAATACAGAAGGTACACAAGA	0.393													0	0	0	0.016522	0	21	58										A	6969151	G	A	6969151	2	1	105	1	0	0	0	0	0	0	0	1	15600	1014	35	2		2	TBC1D14	4	6969151	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2667471	6969151	184185125	103	32250										
TAPT1	202018	broad.mit.edu	37	chr4	16164972	16164972	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aattgtgaacctgtctatctCtaacaaatctttctttgagg	6	8	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:16164972C>G	uc010ied.1	-	14	1744	c.1663G>C	c.(1663-1665)GAG>CAG	p.E555Q	TAPT1_uc011bxd.1_RNA|TAPT1_uc011bxe.1_Missense_Mutation_p.E444Q	NM_153365	NP_699196	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation	555						integral to membrane	growth hormone-releasing hormone receptor activity				0						CTGTCTATCTCTAACAAATCT	0.433													0	0	0	0.012319	0	22	72										G	16164972	C	G	16164972	3	3	105	1	0	0	0	0	1	0	0	0	15551	922	32	1	44	1	TAPT1	4	16164972	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	9195821	16164972	174989304	104	32251										
TAPT1	202018	broad.mit.edu	37	chr4	16175863	16175863	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agaggaataaagcccatcctCcgtgctacagagtcactgta	9	11	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:16175863C>G	uc010ied.1	-	11	1281	c.1200G>C	c.(1198-1200)CGG>CGC	p.R400R	TAPT1_uc011bxd.1_RNA|TAPT1_uc011bxe.1_Silent_p.R289R	NM_153365	NP_699196	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation	400						integral to membrane	growth hormone-releasing hormone receptor activity				0						AGCCCATCCTCCGTGCTACAG	0.328													0	0	0	0.014758	0	5	4										G	16175863	C	G	16175863	2	3	105	1	0	0	0	0	0	0	0	1	15551	842	30	1		1	TAPT1	4	16175863	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10891	16175863	174978413	105	32252										
ANAPC4	29945	broad.mit.edu	37	chr4	25384988	25384988	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggctccagtttcctgtatgcAttggatggaagtgacagtag	13	7	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:25384988A>G	uc003gro.2	+	4	470	c.341A>G	c.(340-342)CAT>CGT	p.H114R	ANAPC4_uc003grp.2_5'UTR	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	114					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				TCCTGTATGCATTGGATGGAA	0.363													0	0	0	0.008871	0	18	55										G	25384988	A	G	25384988	3	3	105	1	0	0	0	0	1	0	0	0	604	217	8	5	351	5	ANAPC4	4	25384988	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	9209125	25384988	165769288	106	32253										
KLB	152831	broad.mit.edu	37	chr4	39448239	39448239	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcgtggtcagtgaggggctGaagcttggcatctccgcgat	16	9	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:39448239G>A	uc003gua.2	+	4	1990	c.1893G>A	c.(1891-1893)CTG>CTA	p.L631L	KLB_uc011byj.1_Silent_p.L622L	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	631	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						GTGAGGGGCTGAAGCTTGGCA	0.627													0	0	0	0.007413	0	20	61										A	39448239	G	A	39448239	2	1	105	1	0	0	0	0	0	0	0	1	8332	1277	45	1		1	KLB	4	39448239	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	14063251	39448239	151706037	107	32254										
N4BP2	55728	broad.mit.edu	37	chr4	40123217	40123217	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggttgaatttgaaagaaatTattagccaaagaggaacttt	10	3	0	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:40123217T>C	uc003guy.3	+	9	3824	c.3486T>C	c.(3484-3486)ATT>ATC	p.I1162I	N4BP2_uc010ifq.2_Silent_p.I1082I|N4BP2_uc010ifr.2_Silent_p.I1082I	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1162						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TGAAAGAAATTATTAGCCAAA	0.378													0	0	0	0.00632	0	30	73										C	40123217	T	C	40123217	2	2	105	1	0	0	0	0	0	0	0	1	10110	1742	61	5		5	N4BP2	4	40123217	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	674978	40123217	151031059	108	32255										
SLC10A4	201780	broad.mit.edu	37	chr4	48485996	48486009	+	Frame_Shift_Del	DEL	CTGCTGGCAGCGCT	CTGCTGGCAGCGCT	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tccgtcggcccgtgggcgcgCtgctggcagcgctctgccag							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:48485996_48486009delCTGCTGGCAGCGCT	uc003gyc.2	+	1	637_650	c.418_431delCTGCTGGCAGCGCT	c.(418-432)CTGCTGGCAGCGCTCfs	p.L140fs		NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	140_144	Helical; (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						CGTGGGCGCGCTGCTGGCAGCGCTCTGCCAGTTC	0.715																		4	5	---	---								-	48486009	CTGCTGGCAGCGCT	-	48485996	7	5	105	1	0	1	0	1	0	0	0	0	14376	796	28	0	420	0	SLC10A4	4	48485996	Frame_Shift_Del	DEL	CTGCTGGCAGCGCT	TCGA-GC-A3RC-01A-11D-A22Z-08	8362779	48485996	142668280	109	32256										
YTHDC1	91746	broad.mit.edu	37	chr4	69182123	69182123	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaggtggagcatggtgctgaTagtaaggatggtgtggaggt	20	2	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:69182123T>C	uc003hdx.2	-	16	2221	c.1868A>G	c.(1867-1869)TAT>TGT	p.Y623C	YTHDC1_uc003hdy.2_Missense_Mutation_p.Y605C	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	623	Pro-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						ATGGTGCTGATAGTAAGGATG	0.448													0	0	0	0.01441	0	68	72										C	69182123	T	C	69182123	3	2	105	1	0	0	0	0	1	0	0	0	17493	1406	49	5	323	5	YTHDC1	4	69182123	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	20696127	69182123	121972153	110	32257										
ANKRD17	26057	broad.mit.edu	37	chr4	74124115	74124115	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gccgccgctgttgtcgctgtCgctgctgctttcgctgctgc	13	15	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:74124115C>G	uc003hgp.2	-	1	388	c.271G>C	c.(271-273)GAC>CAC	p.D91H	ANKRD17_uc003hgq.2_Missense_Mutation_p.D91H|ANKRD17_uc003hgr.2_Missense_Mutation_p.D91H	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	91					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ttgtcgctgtcgctgctgcTT	0.403													0	0	0	0.004007	0	14	37										G	74124115	C	G	74124115	3	3	105	1	0	0	0	0	1	0	0	0	646	884	31	1	7676	1	ANKRD17	4	74124115	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4941992	74124115	117030161	111	32258										
SHROOM3	57619	broad.mit.edu	37	chr4	77670237	77670237	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgttatttggctggtcctgGatctaggtatgtacatgtac	11	6	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:77670237G>A	uc011cbx.1	+	6	4774	c.3821G>A	c.(3820-3822)GGA>GAA	p.G1274E	SHROOM3_uc003hkg.2_Missense_Mutation_p.G1052E	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1274					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCTGGTCCTGGATCTAGGTAT	0.423													0	0	0	0.01441	0	66	60										A	77670237	G	A	77670237	3	1	105	1	0	0	0	0	1	0	0	0	14295	1174	41	1	3843	1	SHROOM3	4	77670237	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3546122	77670237	113484039	112	32259										
PTPN13	5783	broad.mit.edu	37	chr4	87671723	87671723	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtctggccagcagcaccctCaacaaacttgctgttcgacc	8	15	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:87671723C>T	uc003hpz.2	+	18	3231	c.2751C>T	c.(2749-2751)CTC>CTT	p.L917L	PTPN13_uc003hpy.2_Silent_p.L917L|PTPN13_uc003hqa.2_Silent_p.L917L|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	917						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		GCAGCACCCTCAACAAACTTG	0.478													0	0	0	0.007291	0	30	91										T	87671723	C	T	87671723	2	4	105	1	0	0	0	0	0	0	0	1	12782	813	29	1		1	PTPN13	4	87671723	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10001486	87671723	103482553	113	32260										
BANK1	55024	broad.mit.edu	37	chr4	102946407	102946407	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agcaggaagacatacgggcaGagtgcagatggagctgaggc	17	7	0	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:102946407G>A	uc003hvy.3	+	9	1609	c.1335G>A	c.(1333-1335)CAG>CAA	p.Q445Q	BANK1_uc003hvx.3_Silent_p.Q430Q|BANK1_uc010ill.2_Silent_p.Q312Q|BANK1_uc003hvz.3_Silent_p.Q415Q	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	445					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CATACGGGCAGAGTGCAGATG	0.463													0	0	0	0.016522	0	25	64										A	102946407	G	A	102946407	2	1	105	1	0	0	0	0	0	0	0	1	1309	933	33	1		1	BANK1	4	102946407	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	15274684	102946407	88207869	114	32261										
SEC24D	9871	broad.mit.edu	37	chr4	119678896	119678896	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttggaattttttccagcatGgtcttcagttcttcacatat	6	8	4	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:119678896G>T	uc003ici.3	-	11	1673	c.1401C>A	c.(1399-1401)ACC>ACA	p.T467T	SEC24D_uc003ich.3_RNA|SEC24D_uc003icj.3_Silent_p.T468T|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	467					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						TTTCCAGCATGGTCTTCAGTT	0.358													1	0	2.20262e-25	0.013726	2.41176e-25	33	26										T	119678896	G	T	119678896	2	4	105	1	0	0	0	0	0	0	0	1	13997	1335	47	4		4	SEC24D	4	119678896	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	16732489	119678896	71475380	115	32262										
PCDH10	57575	broad.mit.edu	37	chr4	134071531	134071531	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctgtacgtgaacgagaaaaTagaccgcgaacaaatctgca	10	9	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:134071531T>C	uc003iha.2	+	1	1062	c.236T>C	c.(235-237)ATA>ACA	p.I79T	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.I79T	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	79	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AACGAGAAAATAGACCGCGAA	0.552													0	0	0	0.005443	0	28	68										C	134071531	T	C	134071531	3	2	105	1	0	0	0	0	1	0	0	0	11507	1406	49	5	238	5	PCDH10	4	134071531	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	14392635	134071531	57082745	116	32263										
OTUD4	54726	broad.mit.edu	37	chr4	146071800	146071800	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcagtcgaggaggtagtgctGatggggcttttattggcttg	17	5	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:146071800G>C	uc003ika.3	-	13	1067	c.929C>G	c.(928-930)TCA>TGA	p.S310*	OTUD4_uc003ijz.3_Nonsense_Mutation_p.S309*	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	374							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AGGTAGTGCTGATGGGGCTTT	0.423													0	0	0	0.004007	0	16	70										C	146071800	G	C	146071800	4	2	105	1	0	0	0	0	0	1	0	0	11314	1294	45	1	2256	1	OTUD4	4	146071800	Nonsense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	12000269	146071800	45082476	117	32264										
FHDC1	85462	broad.mit.edu	37	chr4	153896047	153896048	+	Frame_Shift_Ins	INS	-	-	C													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccctcctaccggcccccgaaINScacccgccgctcccgcctct							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:153896047_153896048insC	uc003inf.2	+	11	1679_1680	c.1604_1605insC	c.(1603-1605)AACfs	p.N535fs		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	535					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					CGGCCCCCGAACACCCGCCGCT	0.663																		4	6	---	---								C	153896048	-	C	153896047	7	5	105	1	0	1	1	0	0	0	0	0	5876	43	2	0	1646	0	FHDC1	4	153896047	Frame_Shift_Ins	INS	-	TCGA-GC-A3RC-01A-11D-A22Z-08	7824247	153896047	37258229	118	32265										
TRIM2	23321	broad.mit.edu	37	chr4	154216911	154216911	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gacggggagatcctggacaaCaagaacggcacctatgagtt	13	9	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:154216911C>T	uc003ing.2	+	6	1353	c.1152C>T	c.(1150-1152)AAC>AAT	p.N384N	TRIM2_uc003inh.2_Silent_p.N411N	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	384	Filamin.					cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		TCCTGGACAACAAGAACGGCA	0.567													0	0	0	0.004007	0	15	27										T	154216911	C	T	154216911	2	4	105	1	0	0	0	0	0	0	0	1	16491	477	17	2		2	TRIM2	4	154216911	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	320864	154216911	36937365	119	32266										
DCHS2	54798	broad.mit.edu	37	chr4	155156345	155156345	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcttctgctgtttcggcagtCaccatcacatcagtttcccc	7	15	4	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:155156345C>G	uc003inw.2	-	25	8094	c.8094G>C	c.(8092-8094)GTG>GTC	p.V2698V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2698					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTTCGGCAGTCACCATCACAT	0.552													0	0	0	0.012319	0	23	39										G	155156345	C	G	155156345	2	3	105	1	0	0	0	0	0	0	0	1	4288	813	29	1		1	DCHS2	4	155156345	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	939434	155156345	35997931	120	32267										
CTSO	1519	broad.mit.edu	37	chr4	156850779	156850779	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ataatgcctcccagataatcTtgccagctcactgcatctac	5	14	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr4:156850779T>C	uc003ipg.2	-	6	802	c.753A>G	c.(751-753)CAA>CAG	p.Q251Q		NM_001334	NP_001325	P43234	CATO_HUMAN	cathepsin O preproprotein	251					proteolysis	lysosome	cysteine-type endopeptidase activity				0	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		CCAGATAATCTTGCCAGCTCA	0.413													0	0	0	0.004007	0	16	46										C	156850779	T	C	156850779	2	2	105	1	0	0	0	0	0	0	0	1	4040	1606	56	5		5	CTSO	4	156850779	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1694434	156850779	34303497	121	32268										
ADCY2	108	broad.mit.edu	37	chr5	7707855	7707855	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctgtcaccctggagcacttGaatggcgcttataaagtgga	11	9	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:7707855G>C	uc003jdz.1	+	9	1372	c.1305G>C	c.(1303-1305)TTG>TTC	p.L435F	ADCY2_uc011cmo.1_Missense_Mutation_p.L255F	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	435	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TGGAGCACTTGAATGGCGCTT	0.408													0	0	0	0.01441	0	90	56										C	7707855	G	C	7707855	3	2	105	1	0	0	0	0	1	0	0	0	294	1281	45	1	1339	1	ADCY2	5	7707855	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		7707855	173207405	122	32269										
SEMA5A	9037	broad.mit.edu	37	chr5	9119187	9119187	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgcaggagcgctgccgcacCtggaagccgatcccacaggt	13	15	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:9119187C>T	uc003jek.2	-	15	2560	c.1848G>A	c.(1846-1848)CAG>CAA	p.Q616Q		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	616	TSP type-1 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GCTGCCGCACCTGGAAGCCGA	0.652													0	0	0	0.00308	0	6	12										T	9119187	C	T	9119187	2	4	105	1	0	0	0	0	0	0	0	1	14037	680	24	2		2	SEMA5A	5	9119187	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1411332	9119187	171796073	123	32270										
DNAH5	1767	broad.mit.edu	37	chr5	13841840	13841848	+	In_Frame_Del	DEL	ACCTGTTTC	ACCTGTTTC	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agaaattcagttagttggaaAcctgtttcttgaatatttgc							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:13841840_13841848delACCTGTTTC	uc003jfd.2	-	33	5479_5487	c.5437_5445delGAAACAGGT	c.(5437-5445)GAAACAGGTdel	p.ETG1813del		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1813_1815	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTAGTTGGAAACCTGTTTCTTGAATATTT	0.344									Kartagener_syndrome									24	76	---	---								-	13841848	ACCTGTTTC	-	13841840	7	5	105	1	0	1	0	1	0	0	0	0	4604	30	2	0	8617	0	DNAH5	5	13841840	In_Frame_Del	DEL	ACCTGTTTC	TCGA-GC-A3RC-01A-11D-A22Z-08	4722653	13841840	167073420	124	32271										
WDR70	55100	broad.mit.edu	37	chr5	37379640	37379640	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccgcagcttgcggtcaccatGggcttcacggggttcggtga	15	12	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:37379640G>A	uc003jkv.2	+	2	133	c.75G>A	c.(73-75)ATG>ATA	p.M25I	WDR70_uc010iva.1_Missense_Mutation_p.M25I	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	25										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGGTCACCATGGGCTTCACGG	0.622													0	0	0	0.007291	0	30	40										A	37379640	G	A	37379640	3	1	105	1	0	0	0	0	1	0	0	0	17318	1348	47	2	81	2	WDR70	5	37379640	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	23537800	37379640	143535620	125	32272										
SFRS12	140890	broad.mit.edu	37	chr5	65474672	65474672	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagctgaatgaagaaaacctCtctaccaaaacagaagcagt	7	10	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:65474672C>G	uc003juo.2	+	13	2163	c.1503C>G	c.(1501-1503)CTC>CTG	p.L501L	SFRS12_uc003jun.2_Silent_p.L617L|SFRS12_uc010iwy.2_Silent_p.L500L	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	501					mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		AAGAAAACCTCTCTACCAAAA	0.398													0	0	0	0.014323	0	22	51										G	65474672	C	G	65474672	2	3	105	1	0	0	0	0	0	0	0	1	14167	900	32	1		1	SFRS12	5	65474672	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	28095032	65474672	115440588	126	32273										
BDP1	55814	broad.mit.edu	37	chr5	70818196	70818196	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggctaagccaaatttgggaaGagcacacagtaagaaagagg	13	6	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:70818196G>A	uc003kbp.1	+	23	5335	c.5072G>A	c.(5071-5073)AGA>AAA	p.R1691K	BDP1_uc003kbo.2_Missense_Mutation_p.R1691K|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1691					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AATTTGGGAAGAGCACACAGT	0.398													0	0	0	0.01441	0	80	65										A	70818196	G	A	70818196	3	1	105	1	0	0	0	0	1	0	0	0	1395	942	33	1	5162	1	BDP1	5	70818196	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	5343524	70818196	110097064	127	32274										
EPB41L4A	64097	broad.mit.edu	37	chr5	111601977	111601977	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagcagtgttgacgggacagGgcagacggccctgaaggaca	16	10	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:111601977G>A	uc003kpv.1	-	5	660	c.386C>T	c.(385-387)CCC>CTC	p.P129L	EPB41L4A_uc003kpw.1_Missense_Mutation_p.P129L	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	129	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GACGGGACAGGGCAGACGGCC	0.453													0	0	0	0.014758	0	5	6										A	111601977	G	A	111601977	3	1	105	1	0	0	0	0	1	0	0	0	5155	1232	43	2	1750	2	EPB41L4A	5	111601977	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	40783781	111601977	69313283	128	32275										
SRP19	6728	broad.mit.edu	37	chr5	112228423	112228423	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atcagactggctcctcctttGgcaagaactccgagaggagg	12	11	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:112228423G>A	uc011cvv.1	+	4	1417	c.1162G>A	c.(1162-1164)GGC>AGC	p.G388S	SRP19_uc011cvu.1_Missense_Mutation_p.G373S|REEP5_uc011cvw.1_Intron|REEP5_uc003kqe.1_Intron|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_Intron			P09132	SRP19_HUMAN	SubName: Full=Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2;	Error:Variant_position_missing_in_P09132_after_alignment					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		CTCCTCCTTTGGCAAGAACTC	0.493													0	0	0	0.00499	0	18	44										A	112228423	G	A	112228423	3	1	105	1	0	0	0	0	1	0	0	0	15153	1363	47	2		2	SRP19	5	112228423	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	626446	112228423	68686837	129	32276										
P4HA2	8974	broad.mit.edu	37	chr5	131530659	131530659	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acagggcaggcagcatgtctTgttcggtagtcaccttcccc	11	13	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:131530659T>A	uc003kwh.2	-	14	2061	c.1497A>T	c.(1495-1497)ACA>ACT	p.T499T	P4HA2_uc003kwg.2_Silent_p.T497T|P4HA2_uc003kwi.2_Silent_p.T497T|P4HA2_uc003kwk.2_Silent_p.T497T|P4HA2_uc003kwl.2_Silent_p.T499T|P4HA2_uc003kwj.2_Silent_p.T497T	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	499	Fe2OG dioxygenase.					endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CAGCATGTCTTGTTCGGTAGT	0.532													0	0	0	0.010504	0	21	49										A	131530659	T	A	131530659	2	1	105	1	0	0	0	0	0	0	0	1	11357	1799	63	5		5	P4HA2	5	131530659	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	19302236	131530659	49384601	130	32277										
AFF4	27125	broad.mit.edu	37	chr5	132216839	132216840	+	Frame_Shift_Ins	INS	-	-	T													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catgatgcttgcattaaagaINStgagagggcccattacttta							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:132216839_132216840insT	uc003kyd.2	-	21	3811_3812	c.3403_3404insA	c.(3403-3405)ATCfs	p.I1135fs	AFF4_uc011cxk.1_Frame_Shift_Ins_p.I813fs	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	1135					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCATTAAAGATGAGAGGGCCC	0.381																		15	30	---	---								T	132216840	-	T	132216839	7	5	105	1	0	1	1	0	0	0	0	0	359	333	12	0	91	0	AFF4	5	132216839	Frame_Shift_Ins	INS	-	TCGA-GC-A3RC-01A-11D-A22Z-08	686180	132216839	48698421	131	32278										
KDM3B	51780	broad.mit.edu	37	chr5	137750823	137750823	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaatcatttctatttcagagAcagaagagatgggtgatgaa	10	4	3	5			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:137750823A>G	uc003lcy.1	+	12	3402	c.3202A>G	c.(3202-3204)ACA>GCA	p.T1068A	KDM3B_uc010jew.1_Missense_Mutation_p.T724A|KDM3B_uc011cys.1_Missense_Mutation_p.T100A	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1068					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TATTTCAGAGACAGAAGAGAT	0.413													0	0	0	0.010729	0	10	37										G	137750823	A	G	137750823	3	3	105	1	0	0	0	0	1	0	0	0	8127	275	10	5	3248	5	KDM3B	5	137750823	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	5533984	137750823	43164437	132	32279										
PCDHB7	56129	broad.mit.edu	37	chr5	140553173	140553173	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctacaaggtgcaggtgcccGaaaatagccccgttggttcc	11	12	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:140553173G>A	uc003lit.2	+	1	931	c.757G>A	c.(757-759)GAA>AAA	p.E253K		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	253	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGTGCCCGAAAATAGCCC	0.517													0	0	0	0.016522	0	22	63										A	140553173	G	A	140553173	3	1	105	1	0	0	0	0	1	0	0	0	11547	1059	37	1	759	1	PCDHB7	5	140553173	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2802350	140553173	40362087	133	32280										
PCDHGA2	56113	broad.mit.edu	37	chr5	140720625	140720625	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cactctgtacctggtggtggCggtggccgcggtctcctgcg	16	13	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:140720625C>T	uc003ljk.1	+	1	2272	c.2087C>T	c.(2086-2088)GCG>GTG	p.A696V	PCDHGA1_uc003lji.1_Intron|PCDHGA3_uc003ljm.1_5'Flank|PCDHGA3_uc010jfx.1_5'Flank|PCDHGA2_uc011dao.1_Missense_Mutation_p.A696V|PCDHGA3_uc011dap.1_5'Flank	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	696	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGGTGGCGGTGGCCGCG	0.672													0	0	0	0.001168	0	6	151										T	140720625	C	T	140720625	3	4	105	1	0	0	0	0	1	0	0	0	11554	768	27	2	2089	2	PCDHGA2	5	140720625	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	167452	140720625	40194635	134	32281										
PCDHGC4	56098	broad.mit.edu	37	chr5	140865328	140865328	+	Frame_Shift_Del	DEL	G	G	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctggtcccagagctgctcctGgagaagcctttggatcgaga							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:140865328delG	uc003lky.1	+	1	588	c.588delG	c.(586-588)CTGfs	p.L196fs	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Frame_Shift_Del_p.L196fs	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	196	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTGCTCCTGGAGAAGCCTT	0.587																		10	56	---	---								-	140865328	G	-	140865328	7	5	105	1	0	1	0	1	0	0	0	0	11570	1335	47	0	590	0	PCDHGC4	5	140865328	Frame_Shift_Del	DEL	G	TCGA-GC-A3RC-01A-11D-A22Z-08	144703	140865328	40049932	135	32282										
SLC6A7	6534	broad.mit.edu	37	chr5	149588987	149588987	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agcggctccaacaggccagcCggccggccatggactgggga	16	14	0	0	rs144483863	byFrequency	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:149588987C>T	uc003lrr.2	+	14	2091	c.1720C>T	c.(1720-1722)CGG>TGG	p.R574W		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	574	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	ACAGGCCAGCCGGCCGGCCAT	0.622													0	0	0	0.004007	0	15	44										T	149588987	C	T	149588987	3	4	105	1	0	0	0	0	1	0	0	0	14689	643	23	2	1774	2	SLC6A7	5	149588987	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	8723659	149588987	31326273	136	32283										
ANXA6	309	broad.mit.edu	37	chr5	150483166	150483166	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagagacttgtcatatttctCaatgaattccctccggatgt	8	9	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:150483166C>T	uc003ltl.1	-	25	2079	c.1927G>A	c.(1927-1929)GAG>AAG	p.E643K	ANXA6_uc011dcp.1_Missense_Mutation_p.E611K|ANXA6_uc003ltm.1_Missense_Mutation_p.E637K|ANXA6_uc003ltn.1_Missense_Mutation_p.E430K|ANXA6_uc003lto.1_Missense_Mutation_p.E230K	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	643	Annexin 8.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCATATTTCTCAATGAATTCC	0.507													0	0	0	0.001984	0	7	15										T	150483166	C	T	150483166	3	4	105	1	0	0	0	0	1	0	0	0	722	835	29	1	102	1	ANXA6	5	150483166	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	894179	150483166	30432094	137	32284										
EBF1	1879	broad.mit.edu	37	chr5	158223455	158223455	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cccgtcgtccatccttcactCgggctgatggctttgataca	9	14	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:158223455C>T	uc010jip.2	-	9	1109	c.807G>A	c.(805-807)CCG>CCA	p.P269P	EBF1_uc011ddw.1_Silent_p.P137P|EBF1_uc011ddx.1_Silent_p.P270P|EBF1_uc003lxl.3_Silent_p.P238P	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	269	IPT/TIG.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCCTTCACTCGGGCTGATGG	0.463			T	HMGA2	lipoma								0	0	0	0.008361	0	30	7										T	158223455	C	T	158223455	2	4	105	1	0	0	0	0	0	0	0	1	4880	871	31	1		1	EBF1	5	158223455	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	7740289	158223455	22691805	138	32285										
F12	2161	broad.mit.edu	37	chr5	176831360	176831360	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aggtcgcagtactcccagctCagccggtcgcggttcagcac	12	15	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr5:176831360C>T	uc003mgo.3	-	9	904	c.855G>A	c.(853-855)CTG>CTA	p.L285L	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	285	Kringle.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTCCCAGCTCAGCCGGTCGC	0.697									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	19	4										T	176831360	C	T	176831360	2	4	105	1	0	0	0	0	0	0	0	1	5339	813	29	1		1	F12	5	176831360	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	18607905	176831360	4083900	139	32286										
TRIM38	10475	broad.mit.edu	37	chr6	25967107	25967107	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggcgctgtgagcgggcaccAcagcacaaagggcacaccac	13	14	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:25967107A>G	uc003nfm.2	+	3	792	c.357A>G	c.(355-357)CCA>CCG	p.P119P	TRIM38_uc003nfn.2_Silent_p.P119P	NM_006355	NP_006346	O00635	TRI38_HUMAN	tripartite motif-containing 38	119	B box-type.				positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding				0						AGCGGGCACCACAGCACAAAG	0.557													0	0	0	0.00245	0	13	81										G	25967107	A	G	25967107	2	3	105	1	0	0	0	0	0	0	0	1	16509	146	6	5		5	TRIM38	6	25967107	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08		25967107	145147960	140	32287										
HIST1H4D	8360	broad.mit.edu	37	chr6	26189297	26189297	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctttccgcccttaccgcggCcagacatcttgaaaccacag	7	17	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:26189297C>G	uc003ngu.2	-	1	8	c.8G>C	c.(7-9)GGC>GCC	p.G3A		NM_003539	NP_003530	P62805	H4_HUMAN	histone cluster 1, H4d	3					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				CTTACCGCGGCCAGACATCTT	0.512													0	0	0	0.01441	0	82	39										G	26189297	C	G	26189297	3	3	105	1	0	0	0	0	1	0	0	0	7168	739	26	4	307	4	HIST1H4D	6	26189297	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	222190	26189297	144925770	141	32288										
PGBD1	84547	broad.mit.edu	37	chr6	28265744	28265744	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgaagaaatggaacaaagtgGagaagcctcaggaaagccca	12	7	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:28265744G>A	uc003nky.2	+	6	1215	c.845G>A	c.(844-846)GGA>GAA	p.G282E	PGBD1_uc003nkz.2_Missense_Mutation_p.G282E	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	282					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						GAACAAAGTGGAGAAGCCTCA	0.353													0	0	0	0.004482	0	9	76										A	28265744	G	A	28265744	3	1	105	1	0	0	0	0	1	0	0	0	11780	1174	41	1	863	1	PGBD1	6	28265744	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2076447	28265744	142849323	142	32289										
MDC1	9656	broad.mit.edu	37	chr6	30673833	30673833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggtggggctggggcttcagGtactgtaggaggcagacaag	20	6	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:30673833G>A	uc003nrg.3	-	10	3567	c.3127C>T	c.(3127-3129)CCT>TCT	p.P1043S	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.P650S	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1043	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GGGGCTTCAGGTACTGTAGGA	0.532								Other_conserved_DNA_damage_response_genes					0	0	0	0.013114	0	46	36										A	30673833	G	A	30673833	3	1	105	1	0	0	0	0	1	0	0	0	9403	1261	44	2	3166	2	MDC1	6	30673833	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2408089	30673833	140441234	143	32290										
B3GALT4	8705	broad.mit.edu	37	chr6	33246314	33246314	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catcctgcggtgtcgagcaaTagcctggcttcagagctgag	13	11	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:33246314T>A	uc003odr.2	+	1	1398	c.1118T>A	c.(1117-1119)ATA>AAA	p.I373K		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	373	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						TGTCGAGCAATAGCCTGGCTT	0.637													0	0	0	0.008871	0	19	121										A	33246314	T	A	33246314	3	1	105	1	0	0	0	0	1	0	0	0	1249	1406	49	5	1120	5	B3GALT4	6	33246314	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	2572481	33246314	137868753	144	32291										
ITPR3	3710	broad.mit.edu	37	chr6	33636829	33636829	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaagaggaagtgtggctcacGtggactgacaagaataacga	14	6	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:33636829G>T	uc011drk.1	+	18	2304	c.2085G>T	c.(2083-2085)ACG>ACT	p.T695T		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	695	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TGTGGCTCACGTGGACTGACA	0.587													1	0	8.34094e-07	0.008871	8.62746e-07	21	83										T	33636829	G	T	33636829	2	4	105	1	0	0	0	0	0	0	0	1	7922	1132	40	4		4	ITPR3	6	33636829	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	390515	33636829	137478238	145	32292										
UHRF1BP1	54887	broad.mit.edu	37	chr6	34791100	34791100	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggccccccaatggacagtctCccattgcccttgcttcagga	9	16	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:34791100C>A	uc003oju.3	+	4	547	c.313C>A	c.(313-315)CCC>ACC	p.P105T	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	105										ovary(3)	3						TGGACAGTCTCCCATTGCCCT	0.413													1	0	1.19451e-25	0.01441	1.31058e-25	46	211										A	34791100	C	A	34791100	3	1	105	1	0	0	0	0	1	0	0	0	16965	855	30	3	327	3	UHRF1BP1	6	34791100	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1154271	34791100	136323967	146	32293										
C6orf222	389384	broad.mit.edu	37	chr6	36287297	36287297	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtccagcttagaggagtgagCcacctggctgcgcagggtgg	17	10	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:36287297C>G	uc003oly.2	-	11	1937	c.1759G>C	c.(1759-1761)GCT>CCT	p.A587P		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	587										skin(2)|ovary(1)|breast(1)	4						GAGGAGTGAGCCACCTGGCTG	0.552													0	0	0	0.01441	0	74	24										G	36287297	C	G	36287297	3	3	105	1	0	0	0	0	1	0	0	0	2356	739	26	4	207	4	C6orf222	6	36287297	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1496197	36287297	134827770	147	32294										
STK38	11329	broad.mit.edu	37	chr6	36492140	36492140	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caccaaatgctcctctgcctAttacttttaaggactcaaaa	4	12	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:36492140A>G	uc003omg.2	-	3	872	c.284T>C	c.(283-285)ATA>ACA	p.I95T	STK38_uc003omh.2_Missense_Mutation_p.I95T|STK38_uc003omi.2_Missense_Mutation_p.I95T	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	95	Protein kinase.|ATP (By similarity).				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						TCCTCTGCCTATTACTTTTAA	0.378													0	0	0	0.01441	0	96	24										G	36492140	A	G	36492140	3	3	105	1	0	0	0	0	1	0	0	0	15302	449	16	5	1157	5	STK38	6	36492140	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	204843	36492140	134622927	148	32295										
TBC1D22B	55633	broad.mit.edu	37	chr6	37280749	37280749	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctcaagacatgctgcgaagCattgaggctgacagcttttg	11	9	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:37280749C>T	uc003onn.2	+	9	1184	c.1038C>T	c.(1036-1038)AGC>AGT	p.S346S	TBC1D22B_uc010jwt.2_RNA|TBC1D22B_uc003ono.1_Silent_p.S4S|TBC1D22B_uc003onp.2_Silent_p.S4S	NM_017772	NP_060242	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	346	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			OV - Ovarian serous cystadenocarcinoma(102;0.241)			TGCTGCGAAGCATTGAGGCTG	0.478													0	0	0	0.01441	0	98	20										T	37280749	C	T	37280749	2	4	105	1	0	0	0	0	0	0	0	1	15609	709	25	2		2	TBC1D22B	6	37280749	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	788609	37280749	133834318	149	32296										
CD2AP	23607	broad.mit.edu	37	chr6	47512341	47512341	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttattatgttactttctttaGagaccaagaagcgtcagtgt	8	6	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:47512341G>A	uc003oyw.2	+	4	776	c.320_splice	c.e4-1	p.K107_splice		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein						cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACTTTCTTTAGAGACCAAGAA	0.289													0	0	0	0.004007	0	17	84										A	47512341	G	A	47512341	5	1	105	1	0	0	0	0	0	0	1	0	2994	956	33	1	333	1	CD2AP	6	47512341	Splice_Site	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	10231592	47512341	123602726	150	32297										
GPR115	221393	broad.mit.edu	37	chr6	47682609	47682609	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacagagccagagaaaggctAcatgagacctgaggcctgtt	12	10	0	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:47682609A>G	uc003oza.1	+	6	1886	c.1628A>G	c.(1627-1629)TAC>TGC	p.Y543C	GPR115_uc003oyz.1_Missense_Mutation_p.Y600C|GPR115_uc003ozb.1_Missense_Mutation_p.Y541C	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	543	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GAGAAAGGCTACATGAGACCT	0.483													0	0	0	0.01441	0	147	84										G	47682609	A	G	47682609	3	3	105	1	0	0	0	0	1	0	0	0	6632	391	14	5	1646	5	GPR115	6	47682609	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	170268	47682609	123432458	151	32298										
DDX43	55510	broad.mit.edu	37	chr6	74104758	74104758	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaacaggtcctgagggatatAgtgtcggcagaggtggtcgc	17	7	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:74104758A>G	uc003pgw.2	+	1	474	c.130A>G	c.(130-132)AGT>GGT	p.S44G	OOEP_uc003pgv.3_5'UTR|DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	44						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TGAGGGATATAGTGTCGGCAG	0.627											OREG0003900	type=REGULATORY REGION|Gene=BC024931|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.01441	0	67	22										G	74104758	A	G	74104758	3	3	105	1	0	0	0	0	1	0	0	0	4363	420	15	5	132	5	DDX43	6	74104758	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	26422149	74104758	97010309	152	32299										
IRAK1BP1	134728	broad.mit.edu	37	chr6	79577521	79577521	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtggtggtgcgagtgagcagCaccaaggaggcggcagccga	19	9	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:79577521C>T	uc003pim.2	+	1	333	c.228C>T	c.(226-228)AGC>AGT	p.S76S	IRAK1BP1_uc010kbg.1_RNA	NM_001010844	NP_001010844	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1	76	Intrinsically disordered.				I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)		GAGTGAGCAGCACCAAGGAGG	0.627													0	0	0	0.007413	0	19	4										T	79577521	C	T	79577521	2	4	105	1	0	0	0	0	0	0	0	1	7822	709	25	2		2	IRAK1BP1	6	79577521	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5472763	79577521	91537546	153	32300										
BACH2	60468	broad.mit.edu	37	chr6	90660532	90660532	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caagcgctggaggagaagatCacgctcctccggtccagctc	12	14	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:90660532C>T	uc011eab.1	-	7	2102	c.1293G>A	c.(1291-1293)GTG>GTA	p.V431V	BACH2_uc003pnw.2_Silent_p.V431V|BACH2_uc010kch.2_Silent_p.V431V	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	431						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		AGGAGAAGATCACGCTCCTCC	0.592													0	0	0	0.01441	0	59	14										T	90660532	C	T	90660532	2	4	105	1	0	0	0	0	0	0	0	1	1284	813	29	1		1	BACH2	6	90660532	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	11083011	90660532	80454535	154	32301										
ASCC3	10973	broad.mit.edu	37	chr6	101037582	101037582	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgaacattttaactgtttgAtgcttcaaatagtaatagga	7	4	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:101037582A>T	uc003pqk.2	-	36	5807	c.5478T>A	c.(5476-5478)CAT>CAA	p.H1826Q		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1826	SEC63 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TAACTGTTTGATGCTTCAAAT	0.348													0	0	0	0.01441	0	89	36										T	101037582	A	T	101037582	3	4	105	1	0	0	0	0	1	0	0	0	1033	330	12	5	1158	5	ASCC3	6	101037582	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	10377050	101037582	70077485	155	32302										
BEND3	57673	broad.mit.edu	37	chr6	107390828	107390828	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gatcttcttggagcggcgacCcggccgctcgccctcgaagc	13	16	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:107390828C>T	uc003prs.2	-	5	2217	c.1567G>A	c.(1567-1569)GGT>AGT	p.G523S		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	523										ovary(3)	3						GAGCGGCGACCCGGCCGCTCG	0.637													0	0	0	0.005443	0	26	9										T	107390828	C	T	107390828	3	4	105	1	0	0	0	0	1	0	0	0	1399	623	22	2	923	2	BEND3	6	107390828	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	6353246	107390828	63724239	156	32303										
REV3L	5980	broad.mit.edu	37	chr6	111714085	111714085	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caacattaactaaccttggtAtttcatcttgttcccaccga	4	12	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:111714085A>G	uc003puy.3	-	5	979	c.656T>C	c.(655-657)ATA>ACA	p.I219T	REV3L_uc003pux.3_Missense_Mutation_p.I141T|REV3L_uc003puz.3_Missense_Mutation_p.I141T	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	219					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TAACCTTGGTATTTCATCTTG	0.313								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.006999	0	40	17										G	111714085	A	G	111714085	3	3	105	1	0	0	0	0	1	0	0	0	13240	449	16	5	8848	5	REV3L	6	111714085	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	4323257	111714085	59400982	157	32304										
NCOA7	135112	broad.mit.edu	37	chr6	126236524	126236524	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gttcagtggtctcccgatgtCtatggaaaagatgccaaaga	11	8	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:126236524C>G	uc010kes.2	+	13	2591	c.2142C>G	c.(2140-2142)GTC>GTG	p.V714V	NCOA7_uc003qae.3_Silent_p.V714V|NCOA7_uc003qah.2_Silent_p.V703V|NCOA7_uc003qai.2_Silent_p.V714V|NCOA7_uc010ket.2_Silent_p.V599V	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	714					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		CTCCCGATGTCTATGGAAAAG	0.453													0	0	0	0.01441	0	81	28										G	126236524	C	G	126236524	2	3	105	1	0	0	0	0	0	0	0	1	10234	900	32	1		1	NCOA7	6	126236524	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	14522439	126236524	44878543	158	32305										
TMEM181	57583	broad.mit.edu	37	chr6	159052852	159052852	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgctcacaggagtgactatGaggaaatgccgctgcagaac	12	9	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:159052852G>A	uc003qrm.3	+	17	1782	c.1771G>A	c.(1771-1773)GAG>AAG	p.E591K		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	591					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		GAGTGACTATGAGGAAATGCC	0.537													0	0	0	0.001168	0	6	4										A	159052852	G	A	159052852	3	1	105	1	0	0	0	0	1	0	0	0	16097	1291	45	1	1837	1	TMEM181	6	159052852	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	32816328	159052852	12062215	159	32306										
FNDC1	84624	broad.mit.edu	37	chr6	159657323	159657323	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccgaatggacagagaattatCaatggccctcaaggaacaaa	9	9	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr6:159657323C>G	uc010kjv.2	+	12	4244	c.4044C>G	c.(4042-4044)ATC>ATG	p.I1348M	FNDC1_uc010kjw.1_Missense_Mutation_p.I1233M	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1348						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGAGAATTATCAATGGCCCTC	0.393													0	0	0	0.004007	0	16	19										G	159657323	C	G	159657323	3	3	105	1	0	0	0	0	1	0	0	0	5968	816	29	1	4090	1	FNDC1	6	159657323	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	604471	159657323	11457744	160	32307										
INTS1	26173	broad.mit.edu	37	chr7	1517411	1517412	+	Frame_Shift_Ins	INS	-	-	C													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccaccgtccgcacccggcttINSccccccagccaggggctcct							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:1517411_1517412insC	uc003skn.2	-	34	4892_4893	c.4791_4792insG	c.(4789-4794)GGGAAGfs	p.G1597fs	INTS1_uc003skm.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1597_1598					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCACCCGGCTTCCCCCCAGCCA	0.693																		20	27	---	---								C	1517412	-	C	1517411	7	5	105	1	0	1	1	0	0	0	0	0	7775	1792	62	0	1840	0	INTS1	7	1517411	Frame_Shift_Ins	INS	-	TCGA-GC-A3RC-01A-11D-A22Z-08		1517411	157621252	161	32308										
FBXL18	80028	broad.mit.edu	37	chr7	5529800	5529800	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggctgatggctcttctcgcaActctgtgaacagctggggcc	13	12	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:5529800A>T	uc003soo.2	-	5	2138	c.2044T>A	c.(2044-2046)TTG>ATG	p.L682M	FBXL18_uc003son.3_Intron	NM_024963	NP_079239	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	682										central_nervous_system(2)|ovary(1)	3		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TCTTCTCGCAACTCTGTGAAC	0.647													0	0	0	0.00499	0	16	24										T	5529800	A	T	5529800	3	4	105	1	0	0	0	0	1	0	0	0	5714	58	2	5		5	FBXL18	7	5529800	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	4012389	5529800	153608863	162	32309										
ICA1	3382	broad.mit.edu	37	chr7	8198209	8198209	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcatctgctcgctccaagaAgatccactttttgacaaaca	6	12	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:8198209A>T	uc003srm.2	-	7	720	c.653T>A	c.(652-654)CTT>CAT	p.L218H	ICA1_uc010ktr.2_Missense_Mutation_p.L218H|ICA1_uc003srl.2_Missense_Mutation_p.L206H|ICA1_uc003srn.3_Missense_Mutation_p.L144H|ICA1_uc003srp.3_Missense_Mutation_p.L217H|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.L218H|ICA1_uc003srr.2_Missense_Mutation_p.L217H|ICA1_uc003sro.3_Missense_Mutation_p.L218H|ICA1_uc011jxg.1_Missense_Mutation_p.L218H|ICA1_uc003srs.1_Missense_Mutation_p.L218H	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	218	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane		p.L218F(1)		central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CGCTCCAAGAAGATCCACTTT	0.373													0	0	0	0.01441	0	58	80										T	8198209	A	T	8198209	3	4	105	1	0	0	0	0	1	0	0	0	7477	72	3	5	830	5	ICA1	7	8198209	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	2668409	8198209	150940454	163	32310										
ISPD	729920	broad.mit.edu	37	chr7	16415851	16415851	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gacagtagatacaagaggtcGaatggctcctgctgcctgaa	12	9	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:16415851G>A	uc010ktx.2	-	3	550	c.550C>T	c.(550-552)CGA>TGA	p.R184*	ISPD_uc010kty.2_Intron	NM_001101426	NP_001094896	A4D126	ISPD_HUMAN	notch1-induced protein isoform a	184					isoprenoid biosynthetic process		nucleotidyltransferase activity			ovary(1)	1						ACAAGAGGTCGAATGGCTCCT	0.433										Multiple Myeloma(15;0.18)			0	0	0	0.008291	0	8	47										A	16415851	G	A	16415851	4	1	105	1	0	0	0	0	0	1	0	0	7864	1066	37	1	837	1	ISPD	7	16415851	Nonsense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	8217642	16415851	142722812	164	32311										
NFE2L3	9603	broad.mit.edu	37	chr7	26225326	26225326	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctctccagtgtacccatgatGgaagtatcttgatagtaccc	8	11	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:26225326G>A	uc003sxq.2	+	4	2280	c.2008G>A	c.(2008-2010)GGA>AGA	p.G670R		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	670					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						TACCCATGATGGAAGTATCTT	0.423													0	0	0	0.01441	0	56	88										A	26225326	G	A	26225326	3	1	105	1	0	0	0	0	1	0	0	0	10369	1349	47	2	2022	2	NFE2L3	7	26225326	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	9809475	26225326	132913337	165	32312										
AKAP9	10142	broad.mit.edu	37	chr7	91712680	91712680	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atcccagacagatgggactcTgaagatcagtagcagcaatc	10	10	2	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:91712680T>G	uc003ulg.2	+	33	8582	c.8357T>G	c.(8356-8358)CTG>CGG	p.L2786R	AKAP9_uc003ulf.2_Missense_Mutation_p.L2778R|AKAP9_uc003uli.2_Missense_Mutation_p.L2409R|AKAP9_uc003ulj.2_Missense_Mutation_p.L556R|AKAP9_uc003ulk.2_Missense_Mutation_p.L61R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2798					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GATGGGACTCTGAAGATCAGT	0.393			T	BRAF	papillary thyroid								0	0	0	0.004878	0	37	54										G	91712680	T	G	91712680	3	3	105	1	0	0	0	0	1	0	0	0	459	1580	55	5	8487	5	AKAP9	7	91712680	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	65487354	91712680	67425983	166	32313										
PEX1	5189	broad.mit.edu	37	chr7	92118691	92118691	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttaaatgtgactgactaataGccagtctggttttgattggt	10	5	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:92118691G>A	uc003uly.2	-	23	3779	c.3683C>T	c.(3682-3684)GCT>GTT	p.A1228V	PEX1_uc011khr.1_Missense_Mutation_p.A1020V|PEX1_uc010ley.2_Missense_Mutation_p.A1171V|PEX1_uc011khs.1_Missense_Mutation_p.A906V	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	1228					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CTGACTAATAGCCAGTCTGGT	0.363													0	0	0	0.00499	0	18	24										A	92118691	G	A	92118691	3	1	105	1	0	0	0	0	1	0	0	0	11735	971	34	2	176	2	PEX1	7	92118691	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	406011	92118691	67019972	167	32314										
TRRAP	8295	broad.mit.edu	37	chr7	98495469	98495469	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgaaagtcaacccggagcgtGaggacagtgagactcgaaca	13	9	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:98495469G>C	uc003upp.2	+	8	822	c.613G>C	c.(613-615)GAG>CAG	p.E205Q	TRRAP_uc011kis.1_Missense_Mutation_p.E205Q|TRRAP_uc003upr.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	205					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCGGAGCGTGAGGACAGTGA	0.468													0	0	0	0.016522	0	23	118										C	98495469	G	C	98495469	3	2	105	1	0	0	0	0	1	0	0	0	16598	1291	45	1	639	1	TRRAP	7	98495469	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6376778	98495469	60643194	168	32315										
SYPL1	6856	broad.mit.edu	37	chr7	105752637	105752637	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tccttgagcgggttgaggttGatctggaagccggacatcct	14	9	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:105752637G>A	uc003vdp.2	-	2	154	c.72C>T	c.(70-72)ATC>ATT	p.I24I	SYPL1_uc003vdo.2_Silent_p.I6I	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	24	Cytoplasmic (Potential).				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						GGTTGAGGTTGATCTGGAAGC	0.507													0	0	0	0.013537	0	10	13										A	105752637	G	A	105752637	2	1	105	1	0	0	0	0	0	0	0	1	15459	1280	45	1		1	SYPL1	7	105752637	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7257168	105752637	53386026	169	32316										
COG5	10466	broad.mit.edu	37	chr7	107194757	107194757	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgactcaatcccagttgcttGtgccagtaaatcttcatgtc	7	12	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:107194757G>C	uc003ved.2	-	3	883	c.358C>G	c.(358-360)CAA>GAA	p.Q120E	COG5_uc003vec.2_Missense_Mutation_p.Q120E|COG5_uc003vee.2_Missense_Mutation_p.Q120E	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	120					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						CCAGTTGCTTGTGCCAGTAAA	0.299													0	0	0	0.012319	0	20	27										C	107194757	G	C	107194757	3	2	105	1	0	0	0	0	1	0	0	0	3661	1386	48	4	2308	4	COG5	7	107194757	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1442120	107194757	51943906	170	32317										
GIMAP2	26157	broad.mit.edu	37	chr7	150390132	150390133	+	Frame_Shift_Ins	INS	-	-	CACAC													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atggaaactcaaagaagttaINScacagccttggctgaagcaa							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:150390132_150390133insCACAC	uc003who.2	+	3	846_847	c.758_759insCACAC	c.(757-759)TACfs	p.Y253fs	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	253						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAAAGAAGTTACACAGCCTTGG	0.371																		14	71	---	---								CACAC	150390133	-	CACAC	150390132	7	5	105	1	0	1	1	0	0	0	0	0	6380	391	14	0	764	0	GIMAP2	7	150390132	Frame_Shift_Ins	INS	-	TCGA-GC-A3RC-01A-11D-A22Z-08	43195375	150390132	8748531	171	32318										
UBE3C	9690	broad.mit.edu	37	chr7	156979626	156979626	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgctcaacctggtgtggagGgactctgcgagcgaggaggt	17	9	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr7:156979626G>T	uc010lqs.2	+	10	1554	c.1242G>T	c.(1240-1242)AGG>AGT	p.R414S	UBE3C_uc003wnf.2_Missense_Mutation_p.R371S|UBE3C_uc003wng.2_Missense_Mutation_p.R414S	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	414					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TGGTGTGGAGGGACTCTGCGA	0.562													1	0	0.00909568	0.009096	0.00914631	4	46										T	156979626	G	T	156979626	3	4	105	1	0	0	0	0	1	0	0	0	16878	1223	43	4	1280	4	UBE3C	7	156979626	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6589494	156979626	2159037	172	32319										
PPP1R3B	79660	broad.mit.edu	37	chr8	8998903	8998903	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggtgatgttgaatggcatatCtagcgggtcatcgaattccg	13	7	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:8998903C>G	uc003wsn.3	-	2	424	c.259G>C	c.(259-261)GAT>CAT	p.D87H	PPP1R3B_uc003wso.3_Missense_Mutation_p.D86H	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	87					glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		AATGGCATATCTAGCGGGTCA	0.517													0	0	0	0.004878	0	36	66										G	8998903	C	G	8998903	3	3	105	1	0	0	0	0	1	0	0	0	12372	913	32	1	602	1	PPP1R3B	8	8998903	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		8998903	137365119	173	32320										
PPP3CC	5533	broad.mit.edu	37	chr8	22355531	22355531	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tagtgtgtgctgtatttatgGagtttaaagattaatcatcc	9	4	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:22355531G>T	uc003xbs.2	+	4	717	c.390G>T	c.(388-390)TGG>TGT	p.W130C	PPP3CC_uc003xbr.1_Missense_Mutation_p.W130C|PPP3CC_uc011kzi.1_Missense_Mutation_p.W130C|PPP3CC_uc003xbt.2_Missense_Mutation_p.W130C	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma	130					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		TGTATTTATGGAGTTTAAAGA	0.249													1	0	1.49906e-05	0.00245	1.54466e-05	13	23										T	22355531	G	T	22355531	3	4	105	1	0	0	0	0	1	0	0	0	12399	1183	41	3	404	3	PPP3CC	8	22355531	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	13356628	22355531	124008491	174	32321										
FGFR1	2260	broad.mit.edu	37	chr8	38279401	38279401	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	actcccctgcgtcctcaaagGagacatttcttaagtgaagc	8	12	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:38279401G>A	uc003xlp.2	-	8	1937	c.995C>T	c.(994-996)TCC>TTC	p.S332F	FGFR1_uc011lbo.1_Missense_Mutation_p.S330F|FGFR1_uc011lbp.1_Missense_Mutation_p.S243F|FGFR1_uc011lbq.1_Missense_Mutation_p.S241F|FGFR1_uc010lwk.2_Missense_Mutation_p.S324F|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.S172F|FGFR1_uc011lbt.1_Intron|FGFR1_uc011lbu.1_Missense_Mutation_p.S363F|FGFR1_uc011lbv.1_Missense_Mutation_p.S330F|FGFR1_uc011lbw.1_Missense_Mutation_p.S243F|FGFR1_uc011lbx.1_Missense_Mutation_p.S243F	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	332	Ig-like C2-type 3.|Extracellular (Potential).		S -> C (in KAL2).		axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	GTCCTCAAAGGAGACATTTCT	0.488		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						0	0	0	0.004482	0	9	37										A	38279401	G	A	38279401	3	1	105	1	0	0	0	0	1	0	0	0	5863	1174	41	1	1517	1	FGFR1	8	38279401	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	15923870	38279401	108084621	175	32322										
PRKDC	5591	broad.mit.edu	37	chr8	48771464	48771464	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgtgcttgaccagggccgtCaggggcgccatgcactcatg	14	12	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:48771464C>T	uc003xqi.2	-	48	6348	c.6291G>A	c.(6289-6291)CTG>CTA	p.L2097L	PRKDC_uc003xqj.2_Silent_p.L2097L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2097					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCAGGGCCGTCAGGGGCGCCA	0.577								NHEJ					0	0	0	0.009096	0	4	83										T	48771464	C	T	48771464	2	4	105	1	0	0	0	0	0	0	0	1	12521	813	29	1		1	PRKDC	8	48771464	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10492063	48771464	97592558	176	32323										
CHD7	55636	broad.mit.edu	37	chr8	61749497	61749497	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgtgtacaagggcaggaggtTtaggcattaacctcactgct	12	8	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:61749497T>G	uc003xue.2	+	17	4588	c.4111T>G	c.(4111-4113)TTA>GTA	p.L1371V		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1371	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGCAGGAGGTTTAGGCATTAA	0.488													0	0	0	0.010818	0	33	95										G	61749497	T	G	61749497	3	3	105	1	0	0	0	0	1	0	0	0	3330	1838	64	5	4173	5	CHD7	8	61749497	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	12978033	61749497	84614525	177	32324										
UQCRB	7381	broad.mit.edu	37	chr8	97244136	97244136	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tatggcttcttttacatcttCatcctcgtatattgtatcat	4	9	4	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:97244136C>T	uc003yhq.3	-	3	228	c.124G>A	c.(124-126)GAA>AAA	p.E42K	UQCRB_uc011lgt.1_RNA|UQCRB_uc010mbc.2_RNA	NM_006294	NP_006285	P14927	QCR7_HUMAN	ubiquinol-cytochrome c reductase binding	42					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial respiratory chain	ubiquinol-cytochrome-c reductase activity			ovary(1)	1	Breast(36;5.16e-05)					TTTACATCTTCATCCTCGTAT	0.363													0	0	0	0.009535	0	32	35										T	97244136	C	T	97244136	3	4	105	1	0	0	0	0	1	0	0	0	17015	835	29	1	219	1	UQCRB	8	97244136	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	35494639	97244136	49119886	178	32325										
RIMS2	9699	broad.mit.edu	37	chr8	104897639	104897639	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgcaatgcctagatctccatCagattatgctgataggcgat	9	10	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:104897639C>G	uc003yls.2	+	2	387	c.146C>G	c.(145-147)TCA>TGA	p.S49*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.S271*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.S79*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.S79*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.S79*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	302					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGATCTCCATCAGATTATGCT	0.418										HNSCC(12;0.0054)			0	0	0	0.008871	0	19	55										G	104897639	C	G	104897639	4	3	105	1	0	0	0	0	0	1	0	0	13368	838	29	1	952	1	RIMS2	8	104897639	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	7653503	104897639	41466383	179	32326										
ADCY8	114	broad.mit.edu	37	chr8	131896844	131896844	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggagtctttaaacatcagtGagaatggcttgatatgctct	10	6	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:131896844G>A	uc003ytd.3	-	8	2331	c.2075C>T	c.(2074-2076)TCA>TTA	p.S692L	ADCY8_uc010mds.2_Missense_Mutation_p.S692L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	692	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AAACATCAGTGAGAATGGCTT	0.458										HNSCC(32;0.087)			0	0	0	0.013114	0	47	71										A	131896844	G	A	131896844	3	1	105	1	0	0	0	0	1	0	0	0	300	1294	45	1	1724	1	ADCY8	8	131896844	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	26999205	131896844	14467178	180	32327										
PLEC	5339	broad.mit.edu	37	chr8	144992514	144992514	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tccttgttgaggtagccacgCtggtaagccacctccagggg	13	12	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:144992514C>G	uc003zaf.1	-	32	12056	c.11886G>C	c.(11884-11886)CAG>CAC	p.Q3962H	PLEC_uc003zab.1_Missense_Mutation_p.Q3825H|PLEC_uc003zac.1_Missense_Mutation_p.Q3829H|PLEC_uc003zad.2_Missense_Mutation_p.Q3825H|PLEC_uc003zae.1_Missense_Mutation_p.Q3793H|PLEC_uc003zag.1_Missense_Mutation_p.Q3803H|PLEC_uc003zah.2_Missense_Mutation_p.Q3811H|PLEC_uc003zaj.2_Missense_Mutation_p.Q3852H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3962	Globular 2.|Plectin 20.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGTAGCCACGCTGGTAAGCCA	0.682													0	0	0	0.004672	0	3	5										G	144992514	C	G	144992514	3	3	105	1	0	0	0	0	1	0	0	0	12052	796	28	4	2172	4	PLEC	8	144992514	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	13095670	144992514	1371508	181	32328										
CYC1	1537	broad.mit.edu	37	chr8	145152190	145152190	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctacaccataaagcggcacaAgtggtcagtcctgaagagtc	10	11	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr8:145152190A>G	uc003zaz.3	+	7	972	c.929A>G	c.(928-930)AAG>AGG	p.K310R	CYC1_uc003zay.2_Missense_Mutation_p.K251R	NM_001916	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	310					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AAGCGGCACAAGTGGTCAGTC	0.582													0	0	0	0.006122	0	19	25										G	145152190	A	G	145152190	3	3	105	1	0	0	0	0	1	0	0	0	4135	72	3	5	955	5	CYC1	8	145152190	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	159676	145152190	1211832	182	32329										
RANBP6	26953	broad.mit.edu	37	chr9	6014801	6014801	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctccacataacttcaaactCaactgtagagtatcttctaa	3	11	5	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:6014801C>T	uc003zjr.2	-	1	818	c.807G>A	c.(805-807)TTG>TTA	p.L269L	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	269					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ACTTCAAACTCAACTGTAGAG	0.448													0	0	0	0.017118	0	37	59										T	6014801	C	T	6014801	2	4	105	1	0	0	0	0	0	0	0	1	13031	825	29	1		1	RANBP6	9	6014801	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		6014801	135198630	183	32330										
KDM4C	23081	broad.mit.edu	37	chr9	6893118	6893118	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acccaggaggctggagaattCatgatcactttcccatatgg	10	10	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:6893118C>T	uc003zkh.2	+	8	1387	c.807C>T	c.(805-807)TTC>TTT	p.F269F	KDM4C_uc010mhu.2_Silent_p.F291F|KDM4C_uc010mhw.2_Silent_p.F269F|KDM4C_uc011lmi.1_Silent_p.F269F|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.F269F|KDM4C_uc011lmk.1_Silent_p.F88F	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	269	JmjC.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						CTGGAGAATTCATGATCACTT	0.338													0	0	0	0.01441	0	48	56										T	6893118	C	T	6893118	2	4	105	1	0	0	0	0	0	0	0	1	8130	825	29	1		1	KDM4C	9	6893118	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	878317	6893118	134320313	184	32331										
PTPRD	5789	broad.mit.edu	37	chr9	8460538	8460538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atccagatccattgacaccaCggggtcggagtaagggctgg	14	10	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:8460538C>T	uc003zkk.2	-	32	4459	c.3748G>A	c.(3748-3750)GTG>ATG	p.V1250M	PTPRD_uc003zkp.2_Missense_Mutation_p.V839M|PTPRD_uc003zkq.2_Missense_Mutation_p.V839M|PTPRD_uc003zkr.2_Missense_Mutation_p.V834M|PTPRD_uc003zks.2_Missense_Mutation_p.V829M|PTPRD_uc003zkl.2_Missense_Mutation_p.V1241M|PTPRD_uc003zkm.2_Missense_Mutation_p.V1237M|PTPRD_uc003zkn.2_Missense_Mutation_p.V839M|PTPRD_uc003zko.2_Missense_Mutation_p.V836M	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1250	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATTGACACCACGGGGTCGGAG	0.433										TSP Lung(15;0.13)			0	0	0	0.012319	0	20	37										T	8460538	C	T	8460538	3	4	105	1	0	0	0	0	1	0	0	0	12799	536	19	2	2111	2	PTPRD	9	8460538	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1567420	8460538	132752893	185	32332										
MPDZ	8777	broad.mit.edu	37	chr9	13109990	13109990	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tactgcttgacgtcagcccaGtgaaagaaagactggaactt	10	9	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:13109990G>C	uc010mhy.2	-	43	5867	c.5816C>G	c.(5815-5817)ACT>AGT	p.T1939S	MPDZ_uc003zkx.3_Missense_Mutation_p.T163S|MPDZ_uc003zky.3_Missense_Mutation_p.T502S|MPDZ_uc010mib.2_Missense_Mutation_p.T673S|MPDZ_uc010mhx.2_Missense_Mutation_p.T790S|MPDZ_uc011lmm.1_Missense_Mutation_p.T827S|MPDZ_uc003zkz.3_Missense_Mutation_p.T661S|MPDZ_uc010mhz.2_Missense_Mutation_p.T1935S|MPDZ_uc011lmn.1_Missense_Mutation_p.T1906S|MPDZ_uc003zlb.3_Missense_Mutation_p.T1939S	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1968					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CGTCAGCCCAGTGAAAGAAAG	0.453													0	0	0	0.010729	0	12	22										C	13109990	G	C	13109990	3	2	105	1	0	0	0	0	1	0	0	0	9722	1029	36	4	321	4	MPDZ	9	13109990	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	4649452	13109990	128103441	186	32333										
NFIB	4781	broad.mit.edu	37	chr9	14307393	14307393	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atctttgactgctctttcttCatcctttgacattcgcttct	4	12	5	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:14307393C>T	uc003zle.2	-	2	592	c.157G>A	c.(157-159)GAA>AAA	p.E53K	NFIB_uc003zlf.2_Missense_Mutation_p.E53K|NFIB_uc011lmo.1_Missense_Mutation_p.E53K	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	53	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GCTCTTTCTTCATCCTTTGAC	0.448			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								0	0	0	0.001984	0	7	66										T	14307393	C	T	14307393	3	4	105	1	0	0	0	0	1	0	0	0	10371	835	29	1	1137	1	NFIB	9	14307393	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1197403	14307393	126906038	187	32334										
DNAJB5	25822	broad.mit.edu	37	chr9	34997058	34997058	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	actgtgaacattcccactatCgacggccgagtgatcccttt	8	13	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:34997058C>A	uc003zvt.2	+	4	987	c.849C>A	c.(847-849)ATC>ATA	p.I283I	DNAJB5_uc003zvs.2_Silent_p.I317I|DNAJB5_uc011los.1_Silent_p.I355I	NM_012266	NP_036398	O75953	DNJB5_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 5	283					protein folding|response to unfolded protein		heat shock protein binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(32;0.00575)			TTCCCACTATCGACGGCCGAG	0.557													1	0	1.41504e-22	0.011902	1.54006e-22	41	199										A	34997058	C	A	34997058	2	1	105	1	0	0	0	0	0	0	0	1	4623	874	31	3		3	DNAJB5	9	34997058	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	20689665	34997058	106216373	188	32335										
C9orf85	138241	broad.mit.edu	37	chr9	74526714	74526714	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agcaccagaatacgtttagcTtcaaaaatgacaagttcgat	7	8	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:74526714T>A	uc004ain.2	+	1	292	c.64T>A	c.(64-66)TTC>ATC	p.F22I	C9orf85_uc004aio.2_RNA|C9orf85_uc010mou.2_RNA|C9orf85_uc010mov.2_RNA|FAM108B1_uc004ail.2_5'Flank|FAM108B1_uc004aim.1_5'Flank	NM_182505	NP_872311	Q96MD7	CI085_HUMAN	hypothetical protein LOC138241	22											0						TACGTTTAGCTTCAAAAATGA	0.532													0	0	0	0.008361	0	32	150										A	74526714	T	A	74526714	3	1	105	1	0	0	0	0	1	0	0	0	2501	1609	56	5	66	5	C9orf85	9	74526714	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	39529656	74526714	66686717	189	32336										
ALDH1A1	216	broad.mit.edu	37	chr9	75533668	75533668	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctaacacaatgcaagggctcTttcctccaagctccagggtc	8	14	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:75533668T>G	uc004ajd.2	-	8	871	c.818A>C	c.(817-819)AAG>ACG	p.K273T	ALDH1A1_uc011lsh.1_Missense_Mutation_p.K194T|ALDH1A1_uc011lsg.1_Missense_Mutation_p.K99T	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	273					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GCAAGGGCTCTTTCCTCCAAG	0.468													0	0	0	0.017118	0	35	63										G	75533668	T	G	75533668	3	3	105	1	0	0	0	0	1	0	0	0	490	1609	56	5	711	5	ALDH1A1	9	75533668	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1006954	75533668	65679763	190	32337										
GKAP1	80318	broad.mit.edu	37	chr9	86395319	86395319	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagtctttttactaatgtgaTctgtaaatgaaaaagaaaca	6	5	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:86395319T>C	uc004amy.2	-	7	1059	c.563A>G	c.(562-564)GAT>GGT	p.D188G	GKAP1_uc004amz.2_Missense_Mutation_p.D188G|GKAP1_uc011lsu.1_RNA	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	188					signal transduction	Golgi apparatus					0						ACTAATGTGATCTGTAAATGA	0.244													0	0	0	0.016723	0	13	40										C	86395319	T	C	86395319	3	2	105	1	0	0	0	0	1	0	0	0	6423	1449	50	5	565	5	GKAP1	9	86395319	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	10861651	86395319	54818112	191	32338										
ZCCHC6	79670	broad.mit.edu	37	chr9	88967636	88967636	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgacgtggtttctaggcttGttaggtctttatgaaacagt	11	6	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:88967636G>C	uc004aoq.2	-	2	694	c.479C>G	c.(478-480)ACA>AGA	p.T160R	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.T160R|ZCCHC6_uc004aou.2_Missense_Mutation_p.T160R|ZCCHC6_uc004aov.2_Missense_Mutation_p.T160R|ZCCHC6_uc004aow.2_Missense_Mutation_p.T160R|ZCCHC6_uc010mqf.1_Missense_Mutation_p.T160R	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	160					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TTCTAGGCTTGTTAGGTCTTT	0.408													0	0	0	0.01441	0	52	126										C	88967636	G	C	88967636	3	2	105	1	0	0	0	0	1	0	0	0	17589	1377	48	4	4112	4	ZCCHC6	9	88967636	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2572317	88967636	52245795	192	32339										
SECISBP2	79048	broad.mit.edu	37	chr9	91963047	91963047	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgtctccaagaaaatgctgtGagtccagcttttaccagtga	9	10	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:91963047G>A	uc004aqj.1	+	12	1736	c.1656G>A	c.(1654-1656)GTG>GTA	p.V552V	SECISBP2_uc011ltk.1_Silent_p.V551V|SECISBP2_uc004aqk.1_Silent_p.V479V|SECISBP2_uc010mqo.1_Silent_p.V257V|SECISBP2_uc011ltl.1_Silent_p.V484V	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	552					translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3						AAAATGCTGTGAGTCCAGCTT	0.388													0	0	0	0.016723	0	14	59										A	91963047	G	A	91963047	2	1	105	1	0	0	0	0	0	0	0	1	14006	1277	45	1		1	SECISBP2	9	91963047	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2995411	91963047	49250384	193	32340										
FANCC	2176	broad.mit.edu	37	chr9	97887396	97887396	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgctttctccagagcttctAcaaagcactgcgtaaacacc	6	13	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:97887396A>C	uc004avh.2	-	10	1230	c.968T>G	c.(967-969)GTA>GGA	p.V323G	FANCC_uc004avi.3_Missense_Mutation_p.V323G|uc004avj.2_5'Flank	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	323					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)				CAGAGCTTCTACAAAGCACTG	0.438			D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.009096	0	4	35										C	97887396	A	C	97887396	3	2	105	1	0	0	0	0	1	0	0	0	5664	391	14	5	732	5	FANCC	9	97887396	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	5924349	97887396	43326035	194	32341										
TRIM14	9830	broad.mit.edu	37	chr9	100862212	100862212	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagcagtgaccccagcattaCctgaagcctctggacaggat	11	12	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:100862212C>T	uc004ayd.2	-	3	555	c.537_splice	c.e3+1	p.Q179_splice	TRIM14_uc004ayf.1_Splice_Site_p.Q86_splice|TRIM14_uc004ayg.1_Splice_Site_p.Q179_splice|TRIM14_uc004ayh.1_Splice_Site_p.Q179_splice|TRIM14_uc004ayi.1_Splice_Site_p.Q179_splice|TRIM14_uc004ayj.1_Splice_Site_p.Q86_splice	NM_033220	NP_150089	Q14142	TRI14_HUMAN	tripartite motif protein TRIM14 isoform alpha							cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CCCAGCATTACCTGAAGCCTC	0.502													0	0	0	0.005443	0	29	21										T	100862212	C	T	100862212	5	4	105	1	0	0	0	0	0	0	1	0	16486	521	18	2	806	2	TRIM14	9	100862212	Splice_Site	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2974816	100862212	40351219	195	32342										
OR13C2	392376	broad.mit.edu	37	chr9	107367139	107367139	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acttgggcttcatgtacatgAagaggatggtcccatagaat	11	7	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:107367139A>G	uc011lvq.1	-	1	770	c.770T>C	c.(769-771)TTC>TCC	p.F257S		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CATGTACATGAAGAGGATGGT	0.438													0	0	0	0.010818	0	34	89										G	107367139	A	G	107367139	3	3	105	1	0	0	0	0	1	0	0	0	10934	246	9	5	189	5	OR13C2	9	107367139	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	6504927	107367139	33846292	196	32343										
SVEP1	79987	broad.mit.edu	37	chr9	113171084	113171084	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	attctggatcgggggaggttTtccacagtcgagaggaacac	14	8	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:113171084T>C	uc010mtz.2	-	38	7133	c.6796A>G	c.(6796-6798)AAA>GAA	p.K2266E	SVEP1_uc010mty.2_Missense_Mutation_p.K192E	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2266	Sushi 15.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGGGGAGGTTTTCCACAGTCG	0.488													0	0	0	0.005524	0	37	123										C	113171084	T	C	113171084	3	2	105	1	0	0	0	0	1	0	0	0	15417	1850	64	5	3963	5	SVEP1	9	113171084	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	5803945	113171084	28042347	197	32344										
KIAA0368	23392	broad.mit.edu	37	chr9	114246813	114246813	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gttctggtgtggaggtggctGgtgctcccaaaacggctagc	16	9	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:114246813G>T	uc004bfe.1	-	2	100	c.100C>A	c.(100-102)CAG>AAG	p.Q34K	KIAA0368_uc010muc.1_5'Flank	NM_001080398	NP_001073867			KIAA0368 protein												0						GGAGGTGGCTGGTGCTCCCAA	0.622													1	0	1.06961e-07	0.00308	1.11059e-07	8	22										T	114246813	G	T	114246813	3	4	105	1	0	0	0	0	1	0	0	0	8171	1357	47	4	6153	4	KIAA0368	9	114246813	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1075729	114246813	26966618	198	32345										
CDK5RAP2	55755	broad.mit.edu	37	chr9	123163060	123163060	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	actggccatcctcggggagtGagactctccagagaagcttc	12	12	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:123163060G>A	uc004bkf.2	-	35	5592	c.5411C>T	c.(5410-5412)TCA>TTA	p.S1804L	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.S813L|CDK5RAP2_uc004bke.2_Missense_Mutation_p.S1089L|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.S1725L|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.S1069L|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.S1069L|CDK5RAP2_uc011lya.1_Missense_Mutation_p.S1069L|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.S1574L	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1804	Interaction with PCNT and AKAP9.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CTCGGGGAGTGAGACTCTCCA	0.587													0	0	0	0.006999	0	41	45										A	123163060	G	A	123163060	3	1	105	1	0	0	0	0	1	0	0	0	3146	1294	45	1	286	1	CDK5RAP2	9	123163060	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	8916247	123163060	18050371	199	32346										
RC3H2	54542	broad.mit.edu	37	chr9	125613386	125613386	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acatggtcttcacctaaactCtgtttcttctgctttggtgg	8	10	5	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:125613386C>G	uc010mwc.1	-	20	3595	c.3354G>C	c.(3352-3354)CAG>CAC	p.Q1118H	uc004bnb.1_5'Flank|RC3H2_uc004bnc.2_RNA	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	1118						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4						CACCTAAACTCTGTTTCTTCT	0.383													0	0	0	0.01441	0	46	147										G	125613386	C	G	125613386	3	3	105	1	0	0	0	0	1	0	0	0	13167	912	32	1	229	1	RC3H2	9	125613386	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2450326	125613386	15600045	200	32347										
TBC1D13	54662	broad.mit.edu	37	chr9	131568173	131568173	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagcctcagttctttgccttCcgctggctgacactgctgct	9	14	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:131568173C>T	uc010myj.2	+	10	1077	c.954C>T	c.(952-954)TTC>TTT	p.F318F	TBC1D13_uc010myk.2_Silent_p.F193F|TBC1D13_uc010myl.2_Silent_p.F137F	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	318	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0						TCTTTGCCTTCCGCTGGCTGA	0.607													0	0	0	0.00499	0	16	13										T	131568173	C	T	131568173	2	4	105	1	0	0	0	0	0	0	0	1	15599	854	30	1		1	TBC1D13	9	131568173	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5954787	131568173	9645258	201	32348										
TBC1D13	54662	broad.mit.edu	37	chr9	131568242	131568242	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atccgcatctgggactccctCttcgccgatgacaaccgctt	8	16	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:131568242C>G	uc010myj.2	+	10	1146	c.1023C>G	c.(1021-1023)CTC>CTG	p.L341L	TBC1D13_uc010myk.2_Silent_p.L216L|TBC1D13_uc010myl.2_Silent_p.L160L	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	341	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0						GGGACTCCCTCTTCGCCGATG	0.582													0	0	0	0.00499	0	17	27										G	131568242	C	G	131568242	2	3	105	1	0	0	0	0	0	0	0	1	15599	900	32	1		1	TBC1D13	9	131568242	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	69	131568242	9645189	202	32349										
LRRC8A	56262	broad.mit.edu	37	chr9	131670865	131670865	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctcacgggcctcaaggagctGtggctctaccacacagcggc	12	15	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:131670865G>A	uc004bwl.3	+	3	1676	c.1422G>A	c.(1420-1422)CTG>CTA	p.L474L	LRRC8A_uc010myp.2_Silent_p.L474L|LRRC8A_uc010myq.2_Silent_p.L474L	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	474	LRR 5.				pre-B cell differentiation	integral to membrane					0						TCAAGGAGCTGTGGCTCTACC	0.622													0	0	0	0.014758	0	5	29										A	131670865	G	A	131670865	2	1	105	1	0	0	0	0	0	0	0	1	9021	1364	48	2		2	LRRC8A	9	131670865	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	102623	131670865	9542566	203	32350										
ASS1	445	broad.mit.edu	37	chr9	133370345	133370345	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaagtgcaggtgtccgtcctCaagggccaggtgtacatcct	12	11	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:133370345C>G	uc004bzm.2	+	14	1418	c.1062C>G	c.(1060-1062)CTC>CTG	p.L354L	ASS1_uc004bzn.2_Silent_p.L354L|ASS1_uc010mza.2_Silent_p.L430L|ASS1_uc004bzo.2_Silent_p.L335L|ASS1_uc010mzb.2_Silent_p.L392L|ASS1_uc004bzp.2_Silent_p.L354L|ASS1_uc010mzc.2_Silent_p.L354L	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	354					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	TGTCCGTCCTCAAGGGCCAGG	0.592													0	0	0	0.008291	0	11	30										G	133370345	C	G	133370345	2	3	105	1	0	0	0	0	0	0	0	1	1061	813	29	1		1	ASS1	9	133370345	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1699480	133370345	7843086	204	32351										
ABL1	25	broad.mit.edu	37	chr9	133738201	133738201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccctggccgagttggttcatCatcattcaacggtggccgac	11	13	4	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:133738201C>T	uc004bzw.2	+	4	604	c.601C>T	c.(601-603)CAT>TAT	p.H201Y	ABL1_uc004bzv.2_Missense_Mutation_p.H220Y|uc004bzx.1_5'Flank	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	201	SH2.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GTTGGTTCATCATCATTCAAC	0.567			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.010504	0	22	47										T	133738201	C	T	133738201	3	4	105	1	0	0	0	0	1	0	0	0	92	826	29	1	755	1	ABL1	9	133738201	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	367856	133738201	7475230	205	32352										
BAT2L1	84726	broad.mit.edu	37	chr9	134308042	134308042	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tacagagtcttgggaaagttGctgcagcccggcgcatgcca	13	11	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:134308042G>A	uc004can.3	+	2	209	c.154G>A	c.(154-156)GCT>ACT	p.A52T	BAT2L1_uc004cam.1_Missense_Mutation_p.A52T	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	52							protein binding				0						TGGGAAAGTTGCTGCAGCCCG	0.522													0	0	0	0.00499	0	17	55										A	134308042	G	A	134308042	3	1	105	1	0	0	0	0	1	0	0	0	1320	1319	46	2	160	2	BAT2L1	9	134308042	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	569841	134308042	6905389	206	32353										
C9orf96	169436	broad.mit.edu	37	chr9	136253248	136253248	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagatctcttctctgtacctCtgcctggtgatggagttcaa	9	11	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:136253248C>T	uc004cdk.2	+	5	373	c.312C>T	c.(310-312)CTC>CTT	p.L104L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	104	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTCTGTACCTCTGCCTGGTGA	0.572													0	0	0	0.01892	0	23	25										T	136253248	C	T	136253248	2	4	105	1	0	0	0	0	0	0	0	1	2508	900	32	1		1	C9orf96	9	136253248	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1945206	136253248	4960183	207	32354										
SARDH	1757	broad.mit.edu	37	chr9	136599158	136599158	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaggtgccctgtccctccttCagggtccgctgatatggcac	12	14	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:136599158C>T	uc004cep.3	-	2	272	c.138G>A	c.(136-138)CTG>CTA	p.L46L	SARDH_uc004ceo.2_Silent_p.L46L|SARDH_uc011mdn.1_Silent_p.L46L|SARDH_uc011mdo.1_Intron	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	46					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GTCCCTCCTTCAGGGTCCGCT	0.692													0	0	0	0.010729	0	11	29										T	136599158	C	T	136599158	2	4	105	1	0	0	0	0	0	0	0	1	13841	813	29	1		1	SARDH	9	136599158	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	345910	136599158	4614273	208	32355										
COL5A1	1289	broad.mit.edu	37	chr9	137711985	137711985	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catccaggcctgatcgggctCatcggtcctccgggtgaaca	12	14	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr9:137711985C>A	uc004cfe.2	+	58	4852	c.4470C>A	c.(4468-4470)CTC>CTA	p.L1490L	uc004cff.2_RNA	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1490	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGATCGGGCTCATCGGTCCTC	0.637													1	0	3.08376e-08	0.01892	3.21423e-08	22	62										A	137711985	C	A	137711985	2	1	105	1	0	0	0	0	0	0	0	1	3696	813	29	3		3	COL5A1	9	137711985	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1112827	137711985	3501446	209	32356										
SEC61A2	55176	broad.mit.edu	37	chr10	12197894	12197894	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctgtgagaccattgtctggAaggcctttagtcccactacc	9	12	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:12197894A>T	uc001ile.2	+	7	727	c.580A>T	c.(580-582)AAG>TAG	p.K194*	SEC61A2_uc010qbq.1_Nonsense_Mutation_p.K172*|SEC61A2_uc001ilf.3_RNA|SEC61A2_uc001ilh.3_RNA|SEC61A2_uc001ilg.3_Nonsense_Mutation_p.K194*	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	194	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				CATTGTCTGGAAGGCCTTTAG	0.512													0	0	0	0.009718	0	45	91										T	12197894	A	T	12197894	4	4	105	1	0	0	0	0	0	1	0	0	14001	247	9	5	606	5	SEC61A2	10	12197894	Nonsense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08		12197894	123336853	210	32357										
RUFY2	55680	broad.mit.edu	37	chr10	70105549	70105549	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggcaagttagatgagcatctCtgaatgagcagtgcatgaca	12	7	1	5			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:70105549C>T	uc001job.2	-	18	2229	c.1902G>A	c.(1900-1902)CAG>CAA	p.Q634Q	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joa.2_Silent_p.Q189Q	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	648						nucleus	metal ion binding			ovary(1)	1						ATGAGCATCTCTGAATGAGCA	0.408													0	0	0	0.005443	0	29	78										T	70105549	C	T	70105549	2	4	105	1	0	0	0	0	0	0	0	1	13739	912	32	1		1	RUFY2	10	70105549	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	57907655	70105549	65429198	211	32358										
CDH23	64072	broad.mit.edu	37	chr10	73574927	73574927	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagacgctgaccgctgccgaGgccactgccttcgagcgcaa	13	15	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:73574927G>C	uc001jrx.3	+	68	10334	c.9957G>C	c.(9955-9957)GAG>GAC	p.E3319D	CDH23_uc001jsg.3_Missense_Mutation_p.E1079D|CDH23_uc001jsh.3_Missense_Mutation_p.E1044D|CDH23_uc001jsi.3_Missense_Mutation_p.E1044D|CDH23_uc001jsj.3_Missense_Mutation_p.E216D|CDH23_uc010qjr.1_Missense_Mutation_p.E181D	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3319	Cytoplasmic (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCGCTGCCGAGGCCACTGCCT	0.662													0	0	0	0.009096	0	4	9										C	73574927	G	C	73574927	3	2	105	1	0	0	0	0	1	0	0	0	3108	991	35	4	10651	4	CDH23	10	73574927	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3469378	73574927	61959820	212	32359										
AGAP5	729092	broad.mit.edu	37	chr10	75457454	75457454	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagggacacaccgacccctgTtgctggtcaaactcgaggct	12	13	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:75457454T>C	uc009xri.2	-	1	101	c.60A>G	c.(58-60)CAA>CAG	p.Q20Q	AGAP5_uc001juu.3_5'UTR	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	20					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CCGACCCCTGTTGCTGGTCAA	0.607													0	0	0	0.009096	0	4	62										C	75457454	T	C	75457454	2	2	105	1	0	0	0	0	0	0	0	1	371	1722	60	5		5	AGAP5	10	75457454	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1882527	75457454	60077293	213	32360										
ZMIZ1	57178	broad.mit.edu	37	chr10	81049571	81049571	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gactctgtcccttggcagcaGaacaccaaccagcctcccgg	9	17	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:81049571G>A	uc001kaf.2	+	9	1037	c.465G>A	c.(463-465)CAG>CAA	p.Q155Q	ZMIZ1_uc001kag.2_Silent_p.Q31Q|ZMIZ1_uc001kah.1_Silent_p.Q31Q	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	155					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CTTGGCAGCAGAACACCAACC	0.592													0	0	0	0.004482	0	7	42										A	81049571	G	A	81049571	2	1	105	1	0	0	0	0	0	0	0	1	17693	933	33	1		1	ZMIZ1	10	81049571	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	5592117	81049571	54485176	214	32361										
SNCG	6623	broad.mit.edu	37	chr10	88719796	88719796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agcaggccaacgccgtgagcGaggctgtggtgagcagcgtc	17	11	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:88719796G>A	uc001keb.2	+	3	369	c.202G>A	c.(202-204)GAG>AAG	p.E68K	MMRN2_uc001kea.2_5'Flank|MMRN2_uc010qmn.1_5'Flank|MMRN2_uc009xtb.2_5'Flank	NM_003087	NP_003078	O76070	SYUG_HUMAN	synuclein, gamma (breast cancer-specific protein	68				E -> K (in Ref. 1; AAB64109).		microtubule organizing center|perinuclear region of cytoplasm|spindle	protein binding				0						CGCCGTGAGCGAGGCTGTGGT	0.677													0	0	0	0.014758	0	5	6										A	88719796	G	A	88719796	3	1	105	1	0	0	0	0	1	0	0	0	14843	1059	37	1	212	1	SNCG	10	88719796	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7670225	88719796	46814951	215	32362										
IFIT2	3433	broad.mit.edu	37	chr10	91061883	91061883	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagaattgcactgcaaccatGaggtaaatattttcccttcg	8	9	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:91061883G>A	uc009xts.2	+	1	178	c.3G>A	c.(1-3)ATG>ATA	p.M1I	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	1					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				CTGCAACCATGAGGTAAATAT	0.468													0	0	0	0.016723	0	14	36										A	91061883	G	A	91061883	3	1	105	1	0	0	0	0	1	0	0	0	7523	1290	45	1	5	1	IFIT2	10	91061883	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2342087	91061883	44472864	216	32363										
IDE	3416	broad.mit.edu	37	chr10	94294474	94294474	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttctttagggtatttctttgTtcccaaaaaaagcatatgtt	6	6	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:94294474T>C	uc001kia.2	-	3	428	c.352A>G	c.(352-354)ACA>GCA	p.T118A		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	118					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TATTTCTTTGTTCCCAAAAAA	0.348													0	0	0	0.00499	0	18	40										C	94294474	T	C	94294474	3	2	105	1	0	0	0	0	1	0	0	0	7493	1725	60	5	2799	5	IDE	10	94294474	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	3232591	94294474	41240273	217	32364										
CYP2C9	1559	broad.mit.edu	37	chr10	96707616	96707616	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttattttccataaacgttttGattataaagatcagcaattt	4	5	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:96707616G>C	uc001kka.3	+	4	587	c.562G>C	c.(562-564)GAT>CAT	p.D188H	CYP2C9_uc009xut.2_Missense_Mutation_p.D188H	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	188					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TAAACGTTTTGATTATAAAGA	0.383													0	0	0	0.005443	0	28	54										C	96707616	G	C	96707616	3	2	105	1	0	0	0	0	1	0	0	0	4168	1290	45	1	576	1	CYP2C9	10	96707616	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2413142	96707616	38827131	218	32365										
TM9SF3	56889	broad.mit.edu	37	chr10	98307747	98307747	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tactgagcattgatcccctcCtaaaaaggcaaaaaagaaaa	6	9	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:98307747C>T	uc001kmm.3	-	8	1177	c.960_splice	c.e8-1	p.E320_splice	TM9SF3_uc010qot.1_Splice_Site_p.E320_splice|TM9SF3_uc001kmn.1_Splice_Site_p.E89_splice	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor							integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGATCCCCTCCTAAAAAGGCA	0.318													0	0	0	0.012213	0	34	42										T	98307747	C	T	98307747	5	4	105	1	0	0	0	0	0	0	1	0	15976	695	24	2	842	2	TM9SF3	10	98307747	Splice_Site	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1600131	98307747	37227000	219	32366										
TM9SF3	56889	broad.mit.edu	37	chr10	98312731	98312731	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgtaccgagcataatcttttCttaatgttctcattaaaatc	4	8	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:98312731C>T	uc001kmm.3	-	6	963	c.746G>A	c.(745-747)AGA>AAA	p.R249K	TM9SF3_uc010qot.1_Missense_Mutation_p.R249K|TM9SF3_uc001kmn.1_Missense_Mutation_p.R18K	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	249						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		ATAATCTTTTCTTAATGTTCT	0.299													0	0	0	0.016723	0	13	26										T	98312731	C	T	98312731	3	4	105	1	0	0	0	0	1	0	0	0	15976	913	32	1	1063	1	TM9SF3	10	98312731	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4984	98312731	37222016	220	32367										
PITX3	5309	broad.mit.edu	37	chr10	103990676	103990676	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgaaggcgaatggaaaggtCttggcggcgagcggcggggc	20	7	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:103990676C>T	uc001kuu.1	-	4	658	c.504G>A	c.(502-504)AAG>AAA	p.K168K		NM_005029	NP_005020	O75364	PITX3_HUMAN	paired-like homeodomain 3	168					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ATGGAAAGGTCTTGGCGGCGA	0.697													0	0	0	0.001168	0	4	6										T	103990676	C	T	103990676	2	4	105	1	0	0	0	0	0	0	0	1	11956	912	32	1		1	PITX3	10	103990676	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5677945	103990676	31544071	221	32368										
GBF1	8729	broad.mit.edu	37	chr10	104121532	104121532	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agaaccccaagatgccttatGagatgaaggagatggcactg	12	8	0	5			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:104121532G>A	uc001kux.1	+	14	1786	c.1546G>A	c.(1546-1548)GAG>AAG	p.E516K	GBF1_uc001kuy.1_Missense_Mutation_p.E516K|GBF1_uc001kuz.1_Missense_Mutation_p.E517K	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	516					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GATGCCTTATGAGATGAAGGA	0.468													0	0	0	0.003954	0	26	45										A	104121532	G	A	104121532	3	1	105	1	0	0	0	0	1	0	0	0	6271	1291	45	1	1596	1	GBF1	10	104121532	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	130856	104121532	31413215	222	32369										
OBFC1	79991	broad.mit.edu	37	chr10	105657330	105657330	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcggaggaggcactgtgaatCacaggctgattggcaaggga	16	7	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:105657330C>T	uc001kxl.2	-	6	804	c.729G>A	c.(727-729)GTG>GTA	p.V243V	OBFC1_uc001kxm.2_Silent_p.V243V|OBFC1_uc001kxn.2_RNA	NM_024928	NP_079204	Q9H668	STN1_HUMAN	oligonucleotide/oligosaccharide-binding fold	243					positive regulation of DNA replication|telomere maintenance via telomere lengthening		protein binding|single-stranded telomeric DNA binding			ovary(1)	1		Colorectal(252;0.178)		Epithelial(162;3.39e-10)|all cancers(201;1.32e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0151)		CACTGTGAATCACAGGCTGAT	0.517													0	0	0	0.010504	0	19	34										T	105657330	C	T	105657330	2	4	105	1	0	0	0	0	0	0	0	1	10807	813	29	1		1	OBFC1	10	105657330	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1535798	105657330	29877417	223	32370										
SLK	9748	broad.mit.edu	37	chr10	105785423	105785423	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgccttaacccatcaacacAgagccggatttccaaatttt	5	12	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:105785423A>G	uc001kxo.1	+	19	3687	c.3653A>G	c.(3652-3654)CAG>CGG	p.Q1218R	SLK_uc001kxp.1_Missense_Mutation_p.Q1187R	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1218					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CCATCAACACAGAGCCGGATT	0.433													0	0	0	0.008361	0	32	26										G	105785423	A	G	105785423	3	3	105	1	0	0	0	0	1	0	0	0	14748	188	7	5	3727	5	SLK	10	105785423	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	128093	105785423	29749324	224	32371										
TACC2	10579	broad.mit.edu	37	chr10	123846947	123846947	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agggaggttttgactgtgccTgaggccaacagtgagccctg	15	9	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:123846947T>C	uc001lfv.2	+	4	5292	c.4932T>C	c.(4930-4932)CCT>CCC	p.P1644P	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.P1644P|TACC2_uc010qtv.1_Silent_p.P1644P	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1644						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGACTGTGCCTGAGGCCAACA	0.592													0	0	0	0.003163	0	15	19										C	123846947	T	C	123846947	2	2	105	1	0	0	0	0	0	0	0	1	15499	1567	55	5		5	TACC2	10	123846947	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	18061524	123846947	11687800	225	32372										
DMBT1	1755	broad.mit.edu	37	chr10	124399947	124399947	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgacttcacgtctttgacttAtgatctaatccggagtgggt	10	8	3	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr10:124399947A>T	uc001lgk.1	+	52	7053	c.6947A>T	c.(6946-6948)TAT>TTT	p.Y2316F	DMBT1_uc001lgl.1_Missense_Mutation_p.Y2306F|DMBT1_uc001lgm.1_Missense_Mutation_p.Y1688F|DMBT1_uc009xzz.1_Missense_Mutation_p.Y2315F|DMBT1_uc010qtx.1_Missense_Mutation_p.Y1036F|DMBT1_uc009yab.1_Missense_Mutation_p.Y1019F|DMBT1_uc009yac.1_Missense_Mutation_p.Y610F	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2316	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCTTTGACTTATGATCTAATC	0.448													0	0	0	0.00308	0	7	15										T	124399947	A	T	124399947	3	4	105	1	0	0	0	0	1	0	0	0	4577	449	16	5	7153	5	DMBT1	10	124399947	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	553000	124399947	11134800	226	32373										
PHRF1	57661	broad.mit.edu	37	chr11	608824	608824	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagacctcggggaagggagtGctcccccaccagcagcctgg	14	15	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:608824G>A	uc001lqe.2	+	14	3499	c.3368G>A	c.(3367-3369)TGC>TAC	p.C1123Y	PHRF1_uc010qwc.1_Missense_Mutation_p.C1122Y|PHRF1_uc010qwd.1_Missense_Mutation_p.C1121Y|PHRF1_uc010qwe.1_Missense_Mutation_p.C1119Y|PHRF1_uc009ybz.1_Missense_Mutation_p.C913Y|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	1123	Arg-rich.						RNA polymerase binding|zinc ion binding				0						GGAAGGGAGTGCTCCCCCACC	0.632													0	0	0	0.009096	0	4	29										A	608824	G	A	608824	3	1	105	1	0	0	0	0	1	0	0	0	11861	1319	46	2	3415	2	PHRF1	11	608824	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		608824	134397692	227	32374										
DCHS1	8642	broad.mit.edu	37	chr11	6643027	6643027	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagctagatgtgcagctccgTgtcatcaggtggctccaggc	13	12	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:6643027T>C	uc001mem.1	-	21	10290	c.9880A>G	c.(9880-9882)ACG>GCG	p.T3294A	TPP1_uc001mek.1_5'Flank|TPP1_uc001mel.1_5'Flank|TPP1_uc010rar.1_5'Flank	NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	3294	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCAGCTCCGTGTCATCAGGT	0.667													0	0	0	0.006214	0	9	11										C	6643027	T	C	6643027	3	2	105	1	0	0	0	0	1	0	0	0	4287	1696	59	5	20	5	DCHS1	11	6643027	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	6034203	6643027	128363489	228	32375										
DENND5A	23258	broad.mit.edu	37	chr11	9167352	9167352	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cttggtacgatcagaatgtgGtacgggatcactgtttaggg	14	6	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:9167352G>A	uc001mhl.2	-	17	3123	c.2868C>T	c.(2866-2868)TAC>TAT	p.Y956Y	DENND5A_uc001mhk.2_Silent_p.Y299Y|DENND5A_uc010rbw.1_Silent_p.Y956Y|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	956	PLAT.									liver(1)	1						TCAGAATGTGGTACGGGATCA	0.498													0	0	0	0.01441	0	179	234										A	9167352	G	A	9167352	2	1	105	1	0	0	0	0	0	0	0	1	4436	1256	44	2		2	DENND5A	11	9167352	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2524325	9167352	125839164	229	32376										
ADM	133	broad.mit.edu	37	chr11	10327868	10327888	+	Splice_Site	DEL	CCCGCCCGCAGCAGTCCGGAT	CCCGCCCGCAGCAGTCCGGAT	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgcctttcttccccctcccCccgcccgcagcagtccggat					rs2228573	byFrequency	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:10327868_10327888delCCCGCCCGCAGCAGTCCGGAT	uc001mik.1	+	3	866	c.249_splice	c.e3-1	p.S83_splice	ADM_uc001mil.1_Splice_Site_p.S83_splice|ADM_uc001mim.1_Splice_Site_p.S36_splice	NM_001124	NP_001115	P35318	ADML_HUMAN	adrenomedullin precursor						blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)	1				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		TCCCCCTCCCCCCGCCCGCAGCAGTCCGGATGCCGCCCGCA	0.638																		14	22	---	---								-	10327888	CCCGCCCGCAGCAGTCCGGAT	-	10327868	8	5	105	1	0	1	0	1	0	0	1	0	321	638	22	0		0	ADM	11	10327868	Splice_Site	DEL	CCCGCCCGCAGCAGTCCGGAT	TCGA-GC-A3RC-01A-11D-A22Z-08	1160516	10327868	124678648	230	32377										
BTBD10	84280	broad.mit.edu	37	chr11	13410595	13410595	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttccttcttccttctcccagGacattcgaataaagggtctt	6	12	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:13410595G>T	uc001mkz.2	-	9	1468	c.1211C>A	c.(1210-1212)TCC>TAC	p.S404Y	BTBD10_uc010rcl.1_Missense_Mutation_p.S412Y|BTBD10_uc001mla.2_Missense_Mutation_p.S388Y|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.S356Y	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	404						nucleus					0				Epithelial(150;0.0214)		CTTCTCCCAGGACATTCGAAT	0.448													1	0	1.7489e-18	0.011902	1.87704e-18	43	105										T	13410595	G	T	13410595	3	4	105	1	0	0	0	0	1	0	0	0	1538	1174	41	3	220	3	BTBD10	11	13410595	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3082727	13410595	121595921	231	32378										
TPH1	7166	broad.mit.edu	37	chr11	18048081	18048081	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaactgtgtctcacatattgAgtgcagtgaaaaactcgaaa	9	7	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:18048081A>C	uc001mnp.2	-	6	785	c.759T>G	c.(757-759)ACT>ACG	p.T253T	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	253					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	TCACATATTGAGTGCAGTGAA	0.413													0	0	0	0.009718	0	43	50										C	18048081	A	C	18048081	2	2	105	1	0	0	0	0	0	0	0	1	16398	291	11	5		5	TPH1	11	18048081	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	4637486	18048081	116958435	232	32379										
E2F8	79733	broad.mit.edu	37	chr11	19259556	19259570	+	In_Frame_Del	DEL	TGGTAGGTGTGGTTA	TGGTAGGTGTGGTTA	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgagagccttccttgggctTggtaggtgtggttaaagggc							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:19259556_19259570delTGGTAGGTGTGGTTA	uc001mpm.2	-	3	647_661	c.125_139delTAACCACACCTACCA	c.(124-141)TTAACCACACCTACCAAG>TAG	p.42_47LTTPTK>*	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_In_Frame_Del_p.42_47LTTPTK>*|E2F8_uc001mpo.1_In_Frame_Del_p.42_47LTTPTK>*	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	42_47					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TCCTTGGGCTTGGTAGGTGTGGTTAAAGGGCCAAA	0.502																		70	96	---	---								-	19259570	TGGTAGGTGTGGTTA	-	19259556	7	5	105	1	0	1	0	1	0	0	0	0	4873	1821	63	0	2508	0	E2F8	11	19259556	In_Frame_Del	DEL	TGGTAGGTGTGGTTA	TCGA-GC-A3RC-01A-11D-A22Z-08	1211475	19259556	115746960	233	32380										
OR8J1	219477	broad.mit.edu	37	chr11	56127857	56127857	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atggcagggaacctgggcatCatcaccctcaccagtgttga	11	12	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:56127857C>T	uc010rjh.1	+	1	135	c.135C>T	c.(133-135)ATC>ATT	p.I45I		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ACCTGGGCATCATCACCCTCA	0.498													0	0	0	0.01441	0	58	81										T	56127857	C	T	56127857	2	4	105	1	0	0	0	0	0	0	0	1	11241	816	29	1		1	OR8J1	11	56127857	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	36868301	56127857	78878659	234	32381										
OR9Q1	219956	broad.mit.edu	37	chr11	57947216	57947216	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tacacacgctgtgctgctcaGttctttctgttcaccttctt	6	13	5	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:57947216G>A	uc001nmj.2	+	3	616	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				GTGCTGCTCAGTTCTTTCTGT	0.532													0	0	0	0.01441	0	53	79										A	57947216	G	A	57947216	2	1	105	1	0	0	0	0	0	0	0	1	11255	1020	36	2		2	OR9Q1	11	57947216	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1819359	57947216	77059300	235	32382										
MS4A6E	245802	broad.mit.edu	37	chr11	60105401	60105401	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttacaccatggactgccataGagccaaagccagtctggctg	10	12	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:60105401G>A	uc001npd.2	+	2	349	c.335G>A	c.(334-336)AGA>AAA	p.R112K		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	112	Extracellular (Potential).					integral to membrane	receptor activity				0						GACTGCCATAGAGCCAAAGCC	0.373													0	0	0	0.013726	0	36	56										A	60105401	G	A	60105401	3	1	105	1	0	0	0	0	1	0	0	0	9865	942	33	1	341	1	MS4A6E	11	60105401	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2158185	60105401	74901115	236	32383										
AHNAK	79026	broad.mit.edu	37	chr11	62301534	62301534	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtagatgcgctggtactcctCatcatccccgctctgcagaa	9	14	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:62301534C>A	uc001ntl.2	-	5	655	c.355G>T	c.(355-357)GAG>TAG	p.E119*	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	119					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGTACTCCTCATCATCCCCG	0.602													1	0	3.86212e-05	0.008291	3.96452e-05	11	22										A	62301534	C	A	62301534	4	1	105	1	0	0	0	0	0	1	0	0	414	835	29	3	17437	3	AHNAK	11	62301534	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2196133	62301534	72704982	237	32384										
TAF6L	10629	broad.mit.edu	37	chr11	62553845	62553845	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaagcagatggacacaaagtCtatggagccattctggtgag	12	7	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:62553845C>T	uc001nvc.2	+	10	1175	c.1074C>T	c.(1072-1074)GTC>GTT	p.V358V	TMEM179B_uc001nvd.3_5'Flank	NM_006473	NP_006464	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II	358					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			ovary(3)	3						GACACAAAGTCTATGGAGCCA	0.512											OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	27	123										T	62553845	C	T	62553845	2	4	105	1	0	0	0	0	0	0	0	1	15528	900	32	1		1	TAF6L	11	62553845	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	252311	62553845	72452671	238	32385										
MRPL48	51642	broad.mit.edu	37	chr11	73498985	73498985	+	Translation_Start_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcagggtccggtcttcggtTtgcacagctagaggccgcgc	15	12	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:73498985T>A	uc001ouh.3	+	1	69	c.-31T>A	c.(-33--29)GTTTG>GTATG		MRPL48_uc009ytt.2_Translation_Start_Site|MRPL48_uc010rri.1_Translation_Start_Site|MRPL48_uc009ytu.2_Translation_Start_Site	NM_016055	NP_057139	Q96GC5	RM48_HUMAN	mitochondrial ribosomal protein L48 precursor						translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0						GGTCTTCGGTTTGCACAGCTA	0.612													0	0	0	0.016723	0	13	16										A	73498985	T	A	73498985	1	1	105	1	0	0	0	0	0	0	0	0	9812	1856	64	5		5	MRPL48	11	73498985	Translation_Start_Site	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	10945140	73498985	61507531	239	32386										
DNAJB13	374407	broad.mit.edu	37	chr11	73681096	73681096	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctcttcatcttcttcgacatCcagttccccacccgcctcac	3	20	5	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:73681096C>T	uc001ouo.2	+	8	1639	c.888C>T	c.(886-888)ATC>ATT	p.I296I		NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein	296					apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					TCTTCGACATCCAGTTCCCCA	0.577													0	0	0	0.007291	0	29	150										T	73681096	C	T	73681096	2	4	105	1	0	0	0	0	0	0	0	1	4618	845	30	1		1	DNAJB13	11	73681096	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	182111	73681096	61325420	240	32387										
POLD3	10714	broad.mit.edu	37	chr11	74323962	74323962	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgtgactgccagcatccatgTgtacagcatccagaaagcca	9	12	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:74323962T>C	uc001ovf.1	+	5	374	c.299T>C	c.(298-300)GTG>GCG	p.V100A	POLD3_uc009yua.1_5'UTR	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	100					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					AGCATCCATGTGTACAGCATC	0.453													0	0	0	0.01441	0	60	74										C	74323962	T	C	74323962	3	2	105	1	0	0	0	0	1	0	0	0	12192	1696	59	5	317	5	POLD3	11	74323962	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	642866	74323962	60682554	241	32388										
TRPC6	7225	broad.mit.edu	37	chr11	101359784	101359784	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcgtaaaccagaaagattctCataccaaatggagagaagtt	8	7	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:101359784C>G	uc001pgk.3	-	4	1602	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q	TRPC6_uc009ywy.2_Intron|TRPC6_uc009ywz.1_Intron	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	393	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GAAAGATTCTCATACCAAATG	0.433													0	0	0	0.003954	0	25	40										G	101359784	C	G	101359784	3	3	105	1	0	0	0	0	1	0	0	0	16580	835	29	1	1658	1	TRPC6	11	101359784	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	27035822	101359784	33646732	242	32389										
PPP2R1B	5519	broad.mit.edu	37	chr11	111636068	111636068	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcctttctactccaagtgctAgggcaattgttgataacttc	7	10	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:111636068A>G	uc001plx.1	-	2	239	c.155T>C	c.(154-156)CTA>CCA	p.L52P	PPP2R1B_uc001plw.1_Missense_Mutation_p.L52P|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_Missense_Mutation_p.L52P|PPP2R1B_uc010rwl.1_Missense_Mutation_p.L52P	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	52	HEAT 1.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		TCCAAGTGCTAGGGCAATTGT	0.363													0	0	0	0.01441	0	48	92										G	111636068	A	G	111636068	3	3	105	1	0	0	0	0	1	0	0	0	12383	420	15	5	1929	5	PPP2R1B	11	111636068	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	10276284	111636068	23370448	243	32390										
FDXACB1	91893	broad.mit.edu	37	chr11	111749797	111749797	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctctgatccagggtttcgctCagagcggcggcgaaggagaa	15	10	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:111749797C>T	uc001pmc.3	-	1	357	c.60G>A	c.(58-60)CTG>CTA	p.L20L	ALG9_uc010rwo.1_5'UTR|FDXACB1_uc009yyi.2_5'UTR|C11orf1_uc001pmd.2_5'Flank|C11orf1_uc001pme.2_5'Flank	NM_138378	NP_612387	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain	20					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0						GGGTTTCGCTCAGAGCGGCGG	0.667											OREG0021330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	34										T	111749797	C	T	111749797	2	4	105	1	0	0	0	0	0	0	0	1	5806	813	29	1		1	FDXACB1	11	111749797	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	113729	111749797	23256719	244	32391										
MLL	4297	broad.mit.edu	37	chr11	118374637	118374637	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggccgatgacttaagcacttCagatgaagacgacttatact	9	9	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr11:118374637C>G	uc001pta.2	+	27	8044	c.8021C>G	c.(8020-8022)TCA>TGA	p.S2674*	MLL_uc001ptb.2_Nonsense_Mutation_p.S2677*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2674					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TTAAGCACTTCAGATGAAGAC	0.463			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.004656	0	26	37										G	118374637	C	G	118374637	4	3	105	1	0	0	0	0	0	1	0	0	9620	838	29	1	8127	1	MLL	11	118374637	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	6624840	118374637	16631879	245	32392										
B4GALNT3	283358	broad.mit.edu	37	chr12	569632	569632	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cggctgctgctggcgctcgcCgtggtgtctgtggggctctg	18	12	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:569632C>A	uc001qii.1	+	1	90	c.90C>A	c.(88-90)GCC>GCA	p.A30A		NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	30	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGGCGCTCGCCGTGGTGTCTG	0.542													1	0	0.000602214	0.014758	0.000611236	3	5										A	569632	C	A	569632	2	1	105	1	0	0	0	0	0	0	0	1	1268	639	23	4		4	B4GALNT3	12	569632	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		569632	133282263	246	32393										
DYRK4	8798	broad.mit.edu	37	chr12	4702231	4702231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagtgaaatcctgggctacgCggagctgtggttcctgggtc	15	9	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:4702231C>T	uc001qmx.2	+	4	342	c.182C>T	c.(181-183)GCG>GTG	p.A61V	DYRK4_uc009zeh.1_Missense_Mutation_p.A176V|DYRK4_uc001qmy.1_Missense_Mutation_p.A61V	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	61						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			CTGGGCTACGCGGAGCTGTGG	0.458													0	0	0	0.007291	0	29	101										T	4702231	C	T	4702231	3	4	105	1	0	0	0	0	1	0	0	0	4858	768	27	2	188	2	DYRK4	12	4702231	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4132599	4702231	129149664	247	32394										
NCAPD2	9918	broad.mit.edu	37	chr12	6637881	6637881	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagcaagtgcggaaaacagcGgggctggtgatgacccacct	14	11	0	2	rs149244253	byFrequency	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:6637881G>A	uc001qoo.2	+	26	3382	c.3336G>A	c.(3334-3336)GCG>GCA	p.A1112A	NCAPD2_uc010sfd.1_Silent_p.A1067A	NM_014865	NP_055680	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1112					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			ovary(2)|lung(1)|breast(1)|kidney(1)	5						GGAAAACAGCGGGGCTGGTGA	0.597													0	0	0	0.00308	0	8	68										A	6637881	G	A	6637881	2	1	105	1	0	0	0	0	0	0	0	1	10205	1103	39	2		2	NCAPD2	12	6637881	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1935650	6637881	127214014	248	32395										
PTPN6	5777	broad.mit.edu	37	chr12	7064630	7064630	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaggatacagccaaggctggCttctgggaggagtttgaggt	17	6	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:7064630C>T	uc001qsb.2	+	6	971	c.729C>T	c.(727-729)GGC>GGT	p.G243G	PTPN6_uc001qsa.1_Silent_p.G245G|PTPN6_uc010sfr.1_Silent_p.G204G|PTPN6_uc009zfl.1_Silent_p.G243G|PTPN6_uc010sfs.1_Silent_p.G231G	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	243					apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						CCAAGGCTGGCTTCTGGGAGG	0.632													0	0	0	0.006122	0	19	109										T	7064630	C	T	7064630	2	4	105	1	0	0	0	0	0	0	0	1	12792	784	28	2		2	PTPN6	12	7064630	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	426749	7064630	126787265	249	32396										
C12orf36	283422	broad.mit.edu	37	chr12	13526188	13526188	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgatgcctcacatcttcctCaattttctgcttctttttct	3	12	6	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:13526188C>G	uc001rbs.1	-	3	585	c.367G>C	c.(367-369)GAG>CAG	p.E123Q		NM_182558	NP_872364			hypothetical protein LOC283422												0				BRCA - Breast invasive adenocarcinoma(232;0.198)		ACATCTTCCTCAATTTTCTGC	0.408													0	0	0	0.013726	0	30	95										G	13526188	C	G	13526188	3	3	105	1	0	0	0	0	1	0	0	0	1683	835	29	1	53	1	C12orf36	12	13526188	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	6461558	13526188	120325707	250	32397										
C12orf77	196415	broad.mit.edu	37	chr12	25149195	25149195	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtctagtggatccagaatttGaatattatttctggctctgc	9	7	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:25149195G>C	uc001rgf.2	-	2	287	c.82C>G	c.(82-84)CAA>GAA	p.Q28E		NM_001101339	NP_001094809	C9JDV5	CL097_HUMAN	hypothetical protein LOC196415	28											0						TCCAGAATTTGAATATTATTT	0.443													0	0	0	0.00245	0	14	71										C	25149195	G	C	25149195	3	2	105	1	0	0	0	0	1	0	0	0	1716	1299	45	1	367	1	C12orf77	12	25149195	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	11623007	25149195	108702700	251	32398										
TMTC1	83857	broad.mit.edu	37	chr12	29786270	29786270	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggtaggaataggtgaggaatCtataaagagaagaagaatca	13	2	2	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:29786270C>A	uc001rjb.2	-	6	1089	c.615_splice	c.e6-1	p.R205_splice	TMTC1_uc001riz.2_Splice_Site|TMTC1_uc001rja.2_Splice_Site_p.R49_splice|TMTC1_uc001rjc.1_Splice_Site_p.R267_splice	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat							integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGTGAGGAATCTATAAAGAGA	0.443													1	0	1.96292e-10	0.010504	2.06183e-10	22	35										A	29786270	C	A	29786270	5	1	105	1	0	0	0	0	0	0	1	0	16257	927	32	3	1762	3	TMTC1	12	29786270	Splice_Site	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4637075	29786270	104065625	252	32399										
LRRK2	120892	broad.mit.edu	37	chr12	40687375	40687375	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggctcatttcttgtgaaaaaGaaatctaattcaattagtgt	7	5	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:40687375G>C	uc001rmg.3	+	21	2839	c.2718G>C	c.(2716-2718)AAG>AAC	p.K906N	LRRK2_uc001rmh.1_Missense_Mutation_p.K528N|LRRK2_uc009zjw.2_5'Flank	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	906					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGTGAAAAAGAAATCTAATT	0.323													0	0	0	0.003163	0	15	12										C	40687375	G	C	40687375	3	2	105	1	0	0	0	0	1	0	0	0	9033	933	33	1	2800	1	LRRK2	12	40687375	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	10901105	40687375	93164520	253	32400										
LRRK2	120892	broad.mit.edu	37	chr12	40728880	40728880	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctccaagggttccttggatCgcctgcttcagcaggacaaa	10	13	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:40728880C>T	uc001rmg.3	+	40	5990	c.5869C>T	c.(5869-5871)CGC>TGC	p.R1957C	LRRK2_uc009zjw.2_Missense_Mutation_p.R795C|LRRK2_uc001rmi.2_Missense_Mutation_p.R790C	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1957	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.R1957C(1)|p.R1964C(1)		ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTCCTTGGATCGCCTGCTTCA	0.527													0	0	0	0.00499	0	16	53										T	40728880	C	T	40728880	3	4	105	1	0	0	0	0	1	0	0	0	9033	884	31	1	6027	1	LRRK2	12	40728880	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	41505	40728880	93123015	254	32401										
CNTN1	1272	broad.mit.edu	37	chr12	41337465	41337465	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aggaatgatggaggtatctaTacatgctttgcagaaaataa	10	4	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:41337465T>C	uc001rmm.1	+	13	1559	c.1446T>C	c.(1444-1446)TAT>TAC	p.Y482Y	CNTN1_uc009zjy.1_Silent_p.Y482Y|CNTN1_uc001rmn.1_Silent_p.Y471Y|CNTN1_uc001rmo.2_Silent_p.Y482Y	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	482	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GAGGTATCTATACATGCTTTG	0.333													0	0	0	0.012319	0	18	55										C	41337465	T	C	41337465	2	2	105	1	0	0	0	0	0	0	0	1	3640	1413	49	5		5	CNTN1	12	41337465	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	608585	41337465	92514430	255	32402										
SLC38A2	54407	broad.mit.edu	37	chr12	46757568	46757568	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acatgagaaacatagcaaaaAatgaaatcttggacacattc	6	7	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:46757568A>C	uc001rpg.2	-	12	1435	c.995T>G	c.(994-996)TTT>TGT	p.F332C	SLC38A2_uc010sli.1_Missense_Mutation_p.F170C|SLC38A2_uc001rph.2_Missense_Mutation_p.F232C	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	332	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		CATAGCAAAAAATGAAATCTT	0.343													0	0	0	0.01892	0	25	28										C	46757568	A	C	46757568	3	2	105	1	0	0	0	0	1	0	0	0	14604	14	1	5	545	5	SLC38A2	12	46757568	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	5420103	46757568	87094327	256	32403										
C1QL4	338761	broad.mit.edu	37	chr12	49726986	49726986	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggcgtagtcgtagttctggtCcgcgtcctgagcaatggcgc	15	11	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:49726986C>G	uc001rtz.1	-	2	1279	c.568G>C	c.(568-570)GAC>CAC	p.D190H		NM_001008223	NP_001008224	Q86Z23	C1QL4_HUMAN	complement component 1, q subcomponent-like 4	190	C1q.					collagen					0						TAGTTCTGGTCCGCGTCCTGA	0.637													0	0	0	0.013537	0	11	24										G	49726986	C	G	49726986	3	3	105	1	0	0	0	0	1	0	0	0	1961	855	30	1	152	1	C1QL4	12	49726986	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2969418	49726986	84124909	257	32404										
LIMA1	51474	broad.mit.edu	37	chr12	50571654	50571654	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ataggggcatcttctaccccTgggctgtgaggggtctccct	13	12	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:50571654T>A	uc001rwj.3	-	11	1647	c.1473A>T	c.(1471-1473)CCA>CCT	p.P491P	LIMA1_uc001rwg.3_Silent_p.P189P|LIMA1_uc001rwh.3_Silent_p.P330P|LIMA1_uc001rwi.3_Silent_p.P332P|LIMA1_uc001rwk.3_Silent_p.P492P|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	491				P -> Q (in Ref. 2; AAF67491).	actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CTTCTACCCCTGGGCTGTGAG	0.522													0	0	0	0.013726	0	33	107										A	50571654	T	A	50571654	2	1	105	1	0	0	0	0	0	0	0	1	8796	1567	55	5		5	LIMA1	12	50571654	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	844668	50571654	83280241	258	32405										
DIP2B	57609	broad.mit.edu	37	chr12	51065124	51065124	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catcttctacgctgtcccacGgagaggtcaaaggaaccagt	10	12	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:51065124G>A	uc001rwv.2	+	5	739	c.583G>A	c.(583-585)GGA>AGA	p.G195R	DIP2B_uc001rwu.2_Missense_Mutation_p.G195R|DIP2B_uc009zls.1_Missense_Mutation_p.G77R	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	195	Ser-rich.					nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GCTGTCCCACGGAGAGGTCAA	0.483													0	0	0	0.01441	0	60	43										A	51065124	G	A	51065124	3	1	105	1	0	0	0	0	1	0	0	0	4528	1117	39	2	601	2	DIP2B	12	51065124	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	493470	51065124	82786771	259	32406										
SCN8A	6334	broad.mit.edu	37	chr12	52115497	52115497	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gagggccgccgggactccctCttcatccccatccgggcccg	12	19	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:52115497C>G	uc001ryw.2	+	12	1981	c.1803C>G	c.(1801-1803)CTC>CTG	p.L601L	SCN8A_uc010snl.1_Silent_p.L466L|SCN8A_uc001ryx.1_Silent_p.L466L|SCN8A_uc001ryz.1_Silent_p.L466L|SCN8A_uc001ryy.2_Silent_p.L466L	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	601					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGGACTCCCTCTTCATCCCCA	0.622													0	0	0	0.014758	0	5	11										G	52115497	C	G	52115497	2	3	105	1	0	0	0	0	0	0	0	1	13924	900	32	1		1	SCN8A	12	52115497	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1050373	52115497	81736398	260	32407										
PA2G4	5036	broad.mit.edu	37	chr12	56500804	56500804	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcccaccagcatttcggtaaAtaactgtgtatgtcacttct	6	11	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:56500804A>G	uc001sjm.2	+	3	667	c.248A>G	c.(247-249)AAT>AGT	p.N83S	PA2G4_uc009zol.2_Missense_Mutation_p.N83S|PA2G4_uc009zom.2_Missense_Mutation_p.N83S	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	83					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			ATTTCGGTAAATAACTGTGTA	0.428													0	0	0	0.00632	0	29	69										G	56500804	A	G	56500804	3	3	105	1	0	0	0	0	1	0	0	0	11361	101	4	5	258	5	PA2G4	12	56500804	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	4385307	56500804	77351091	261	32408										
PIP4K2C	79837	broad.mit.edu	37	chr12	57992965	57992965	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcaatatgtttagccaccgtCttcctgtgcacaggaagtat	9	10	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:57992965C>T	uc001sou.2	+	5	762	c.631C>T	c.(631-633)CTT>TTT	p.L211F	PIP4K2C_uc001sot.2_Missense_Mutation_p.L211F|PIP4K2C_uc010srs.1_Missense_Mutation_p.L193F|PIP4K2C_uc010srt.1_Missense_Mutation_p.L163F	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	211	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					TAGCCACCGTCTTCCTGTGCA	0.537													0	0	0	0.006122	0	18	36										T	57992965	C	T	57992965	3	4	105	1	0	0	0	0	1	0	0	0	11938	913	32	1	649	1	PIP4K2C	12	57992965	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1492161	57992965	75858930	262	32409										
SLC16A7	9194	broad.mit.edu	37	chr12	60168667	60168667	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctggttccctcatgagaccCcttggacccaatcaaaccac	7	16	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:60168667C>G	uc001sqs.2	+	5	890	c.591C>G	c.(589-591)CCC>CCG	p.P197P	SLC16A7_uc001sqt.2_Silent_p.P197P|SLC16A7_uc001squ.2_Silent_p.P197P|SLC16A7_uc009zqi.2_Silent_p.P98P|SLC16A7_uc010ssi.1_Silent_p.P98P	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	197	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TCATGAGACCCCTTGGACCCA	0.403													0	0	0	0.008361	0	30	18										G	60168667	C	G	60168667	2	3	105	1	0	0	0	0	0	0	0	1	14413	610	22	4		4	SLC16A7	12	60168667	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2175702	60168667	73683228	263	32410										
GRIP1	23426	broad.mit.edu	37	chr12	66932910	66932910	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	accactctttctcccacattCttcagcaagctgatgatctc	4	15	5	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:66932910C>G	uc001stk.2	-	4	607	c.366G>C	c.(364-366)AAG>AAC	p.K122N	GRIP1_uc010sta.1_Missense_Mutation_p.K66N|GRIP1_uc001stl.1_Missense_Mutation_p.K66N|GRIP1_uc001stm.2_Missense_Mutation_p.K122N	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	122	PDZ 1.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CTCCCACATTCTTCAGCAAGC	0.378													0	0	0	0.004482	0	6	117										G	66932910	C	G	66932910	3	3	105	1	0	0	0	0	1	0	0	0	6787	912	32	1	2948	1	GRIP1	12	66932910	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	6764243	66932910	66918985	264	32411										
CPSF6	11052	broad.mit.edu	37	chr12	69652399	69652416	+	In_Frame_Del	DEL	GGTCCTCCAGGCCCACCT	GGTCCTCCAGGCCCACCT	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctccaccacgtccacccttaGgtcctccaggcccacctggt							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:69652399_69652416delGGTCCTCCAGGCCCACCT	uc001sut.3	+	6	834_851	c.724_741delGGTCCTCCAGGCCCACCT	c.(724-741)GGTCCTCCAGGCCCACCTdel	p.GPPGPP248del	CPSF6_uc001suu.3_In_Frame_Del_p.GPPGPP285del|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	248_253	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCACCAG	0.491																		7	71	---	---								-	69652416	GGTCCTCCAGGCCCACCT	-	69652399	7	5	105	1	0	1	0	1	0	0	0	0	3829	1000	35	0	746	0	CPSF6	12	69652399	In_Frame_Del	DEL	GGTCCTCCAGGCCCACCT	TCGA-GC-A3RC-01A-11D-A22Z-08	2719489	69652399	64199496	265	32412										
NTN4	59277	broad.mit.edu	37	chr12	96077360	96077360	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tctccgaagccccagtatccCaccatgcacctgtcacaacg	6	18	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:96077360C>T	uc001tei.2	-	6	1757	c.1308G>A	c.(1306-1308)GTG>GTA	p.V436V	NTN4_uc009ztf.2_Silent_p.V436V|NTN4_uc009ztg.2_Silent_p.V399V	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	436	Laminin EGF-like 3.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCCAGTATCCCACCATGCACC	0.597													0	0	0	0.013537	0	12	30										T	96077360	C	T	96077360	2	4	105	1	0	0	0	0	0	0	0	1	10702	581	21	2		2	NTN4	12	96077360	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	26424961	96077360	37774535	266	32413										
C12orf63	374467	broad.mit.edu	37	chr12	97114276	97114276	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtgctccgctggcgagctgGagattgtggtggaggcccgg	19	9	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:97114276G>C	uc001tet.1	+	17	2251	c.2173G>C	c.(2173-2175)GAG>CAG	p.E725Q		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	725										skin(6)|ovary(1)	7						TGGCGAGCTGGAGATTGTGGT	0.587													0	0	0	0.014758	0	5	10										C	97114276	G	C	97114276	3	2	105	1	0	0	0	0	1	0	0	0	1706	1175	41	1	2235	1	C12orf63	12	97114276	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1036916	97114276	36737619	267	32414										
ANKS1B	56899	broad.mit.edu	37	chr12	100377945	100377945	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggatccctcctttcctgccaGacaggagtttctccaccaga	8	15	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:100377945G>T	uc001tge.1	-	1	488	c.71C>A	c.(70-72)TCT>TAT	p.S24Y	ANKS1B_uc001tgf.1_Translation_Start_Site|ANKS1B_uc009ztt.1_Missense_Mutation_p.S24Y	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	24	ANK 1.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTTCCTGCCAGACAGGAGTTT	0.612													1	0	0.000602214	0.014758	0.000611236	5	16										T	100377945	G	T	100377945	3	4	105	1	0	0	0	0	1	0	0	0	689	942	33	3	4067	3	ANKS1B	12	100377945	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3263669	100377945	33473950	268	32415										
UTP20	27340	broad.mit.edu	37	chr12	101685532	101685532	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtttgcaggaatcgctcttgGatctacacacaaaagtaaca	8	9	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:101685532G>A	uc001tia.1	+	9	1060	c.904G>A	c.(904-906)GAT>AAT	p.D302N		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	302					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						ATCGCTCTTGGATCTACACAC	0.328													0	0	0	0.006214	0	8	20										A	101685532	G	A	101685532	3	1	105	1	0	0	0	0	1	0	0	0	17096	1174	41	1	938	1	UTP20	12	101685532	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1307587	101685532	32166363	269	32416										
UBE3B	89910	broad.mit.edu	37	chr12	109935699	109935699	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcatgtctgtgcctgctctgGtgactcatctcagcacagtg	10	12	5	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:109935699G>A	uc001top.2	+	10	1393	c.790G>A	c.(790-792)GTG>ATG	p.V264M	UBE3B_uc001toq.2_Missense_Mutation_p.V264M|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.V264M	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	264					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GCCTGCTCTGGTGACTCATCT	0.468													0	0	0	0.014323	0	23	46										A	109935699	G	A	109935699	3	1	105	1	0	0	0	0	1	0	0	0	16877	1261	44	2	820	2	UBE3B	12	109935699	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	8250167	109935699	23916196	270	32417										
IFT81	28981	broad.mit.edu	37	chr12	110643430	110643430	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttcaacttcgtcgtgctactGatgagatgaaggcatatatc	9	8	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:110643430G>C	uc001tqi.2	+	17	1877	c.1747G>C	c.(1747-1749)GAT>CAT	p.D583H	IFT81_uc001tqh.2_Missense_Mutation_p.D583H|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	583	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						TCGTGCTACTGATGAGATGAA	0.313													0	0	0	0.009535	0	32	75										C	110643430	G	C	110643430	3	2	105	1	0	0	0	0	1	0	0	0	7565	1290	45	1	1921	1	IFT81	12	110643430	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	707731	110643430	23208465	271	32418										
RAD9B	144715	broad.mit.edu	37	chr12	110956514	110956514	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgtacacagtgagatgtttgTtggctcagatgagtttgact	12	5	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:110956514T>C	uc001trf.3	+	7	767	c.629T>C	c.(628-630)GTT>GCT	p.V210A	RAD9B_uc001trg.3_Missense_Mutation_p.V210A|RAD9B_uc010sya.1_Missense_Mutation_p.V141A|RAD9B_uc001tre.3_Missense_Mutation_p.V138A|RAD9B_uc001trd.3_Missense_Mutation_p.V52A	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	RAD9 homolog B	207					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2						GAGATGTTTGTTGGCTCAGAT	0.289													0	0	0	0.006214	0	10	23										C	110956514	T	C	110956514	3	2	105	1	0	0	0	0	1	0	0	0	12996	1725	60	5	655	5	RAD9B	12	110956514	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	313084	110956514	22895381	272	32419										
RNF10	9921	broad.mit.edu	37	chr12	120995374	120995374	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgccacagagtcacatcagTatgttgttggtgataccatt	9	8	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:120995374T>C	uc001typ.3	+	6	1339	c.856T>C	c.(856-858)TAT>CAT	p.Y286H	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.Y192H	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	286					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCACATCAGTATGTTGTTGG	0.448													0	0	0	0.005524	0	38	77										C	120995374	T	C	120995374	3	2	105	1	0	0	0	0	1	0	0	0	13422	1638	57	5	878	5	RNF10	12	120995374	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	10038860	120995374	12856521	273	32420										
TMEM120B	144404	broad.mit.edu	37	chr12	122213008	122213008	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgtcacgctgtttgagctctCcagccacgaggaatgcagag	12	12	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:122213008C>G	uc001ubc.3	+	11	1022	c.878C>G	c.(877-879)TCC>TGC	p.S293C	TMEM120B_uc009zxh.2_3'UTR|TMEM120B_uc001uba.1_5'Flank	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	293						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		TTTGAGCTCTCCAGCCACGAG	0.517													0	0	0	0.016723	0	12	14										G	122213008	C	G	122213008	3	3	105	1	0	0	0	0	1	0	0	0	16031	855	30	1	920	1	TMEM120B	12	122213008	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1217634	122213008	11638887	274	32421										
MPHOSPH9	10198	broad.mit.edu	37	chr12	123645694	123645694	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgtttttacctggtccttttCttttgtaagttcatcaaaaa	5	7	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:123645694C>G	uc001uel.2	-	18	3021	c.2914G>C	c.(2914-2916)GAA>CAA	p.E972Q	MPHOSPH9_uc010tal.1_Missense_Mutation_p.E426Q|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Missense_Mutation_p.E426Q	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	972	Potential.				M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TGGTCCTTTTCTTTTGTAAGT	0.343													0	0	0	0.004007	0	16	34										G	123645694	C	G	123645694	3	3	105	1	0	0	0	0	1	0	0	0	9728	922	32	1	193	1	MPHOSPH9	12	123645694	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1432686	123645694	10206201	275	32422			1	144		3	3	238	C		5.76582e-06
MPHOSPH9	10198	broad.mit.edu	37	chr12	123645916	123645916	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atggttatcggtggctttctCagaataagttttttctgtca	9	6	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:123645916C>T	uc001uel.2	-	18	2799	c.2692G>A	c.(2692-2694)GAG>AAG	p.E898K	MPHOSPH9_uc010tal.1_Missense_Mutation_p.E352K|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Missense_Mutation_p.E352K	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	898					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GTGGCTTTCTCAGAATAAGTT	0.373													0	0	0	0.004656	0	24	69										T	123645916	C	T	123645916	3	4	105	1	0	0	0	0	1	0	0	0	9728	835	29	1	415	1	MPHOSPH9	12	123645916	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	222	123645916	10205979	276	32423			1	144		3	3	238	C		5.76582e-06
MPHOSPH9	10198	broad.mit.edu	37	chr12	123645931	123645931	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttctcagaataagttttttCtgtcagagaggagagaaatt	9	4	3	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr12:123645931C>G	uc001uel.2	-	18	2785	c.2678_splice	c.e18-1	p.E893_splice	MPHOSPH9_uc010tal.1_Splice_Site_p.E347_splice|MPHOSPH9_uc010tam.1_Splice_Site|MPHOSPH9_uc001uem.2_Splice_Site_p.E347_splice	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9						M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TAAGTTTTTTCTGTCAGAGAG	0.368													0	0	0	0.003954	0	23	61										G	123645931	C	G	123645931	5	3	105	1	0	0	0	0	0	0	1	0	9728	927	32	1	430	1	MPHOSPH9	12	123645931	Splice_Site	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	15	123645931	10205964	277	32424			1	144		3	3	238	C		5.76582e-06
CENPJ	55835	broad.mit.edu	37	chr13	25484207	25484207	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtgcttctggctctgatcatCaggcagtaaactcaaacctt	8	11	5	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:25484207C>T	uc001upt.3	-	4	839	c.586G>A	c.(586-588)GAT>AAT	p.D196N	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	196					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CTCTGATCATCAGGCAGTAAA	0.478													0	0	0	0.01441	0	50	59										T	25484207	C	T	25484207	3	4	105	1	0	0	0	0	1	0	0	0	3234	826	29	1	3486	1	CENPJ	13	25484207	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		25484207	89685671	278	32425										
ZC3H13	23091	broad.mit.edu	37	chr13	46619528	46619529	+	Frame_Shift_Ins	INS	-	-	TGCTGTACTGCCAG													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tactagtgacaactcacctcINStgctgtactgccagtgctgg							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:46619528_46619529insTGCTGTACTGCCAG	uc010tfw.1	-	1	120_121	c.114_115insCTGGCAGTACAGCA	c.(112-117)GCAGAGfs	p.A38fs	ZC3H13_uc001vas.1_Frame_Shift_Ins_p.A38fs|ZC3H13_uc001vat.1_Frame_Shift_Ins_p.A38fs	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	38_39	C3H1-type.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CAACTCACCTCTGCTGTACTGC	0.416																		25	178	---	---								TGCTGTACTGCCAG	46619529	-	TGCTGTACTGCCAG	46619528	7	5	105	1	0	1	1	0	0	0	0	0	17562	922	32	0	4643	0	ZC3H13	13	46619528	Frame_Shift_Ins	INS	-	TCGA-GC-A3RC-01A-11D-A22Z-08	21135321	46619528	68550350	279	32426										
LPAR6	10161	broad.mit.edu	37	chr13	48985570	48985570	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atcttactttttaaggtctgTaggttatgctgaataaaatt	7	4	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:48985570T>C	uc010acu.2	-	1	2084	c.990A>G	c.(988-990)CTA>CTG	p.L330L	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Silent_p.L330L|LPAR6_uc001vcf.2_Silent_p.L330L	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	330	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						TTAAGGTCTGTAGGTTATGCT	0.358													0	0	0	0.01441	0	66	22										C	48985570	T	C	48985570	2	2	105	1	0	0	0	0	0	0	0	1	8909	1625	57	5		5	LPAR6	13	48985570	Silent	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	2366042	48985570	66184308	280	32427										
PCDH9	5101	broad.mit.edu	37	chr13	67799881	67799881	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tattgtcccattgataggttCatgaactgcatcatcgggtt	9	8	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:67799881C>T	uc001vik.2	-	2	3384	c.2692G>A	c.(2692-2694)GAA>AAA	p.E898K	PCDH9_uc001vil.2_Missense_Mutation_p.E898K|PCDH9_uc010thl.1_Missense_Mutation_p.E898K|PCDH9_uc001vin.3_Missense_Mutation_p.E898K	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	898	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTGATAGGTTCATGAACTGCA	0.438													0	0	0	0.01441	0	82	113										T	67799881	C	T	67799881	3	4	105	1	0	0	0	0	1	0	0	0	11518	835	29	1	1037	1	PCDH9	13	67799881	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	18814311	67799881	47369997	281	32428										
PCDH9	5101	broad.mit.edu	37	chr13	67800603	67800603	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgatagttacttttgcagtaGaggaacgaggtggttgtcct	13	5	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:67800603G>C	uc001vik.2	-	2	2662	c.1970C>G	c.(1969-1971)TCT>TGT	p.S657C	PCDH9_uc001vil.2_Missense_Mutation_p.S657C|PCDH9_uc010thl.1_Missense_Mutation_p.S657C|PCDH9_uc001vin.3_Missense_Mutation_p.S657C	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	657	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TTTTGCAGTAGAGGAACGAGG	0.438													0	0	0	0.006999	0	41	137										C	67800603	G	C	67800603	3	2	105	1	0	0	0	0	1	0	0	0	11518	942	33	1	1759	1	PCDH9	13	67800603	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	722	67800603	47369275	282	32429										
SLITRK1	114798	broad.mit.edu	37	chr13	84455102	84455102	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gttaccccggaggtcgaggtGggtgatgggcacatactgga	17	8	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:84455102G>A	uc001vlk.2	-	1	1427	c.541C>T	c.(541-543)CAC>TAC	p.H181Y		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	181	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AGGTCGAGGTGGGTGATGGGC	0.537													0	0	0	0.01441	0	55	97										A	84455102	G	A	84455102	3	1	105	1	0	0	0	0	1	0	0	0	14742	1348	47	2	1553	2	SLITRK1	13	84455102	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	16654499	84455102	30714776	283	32430										
GPC5	2262	broad.mit.edu	37	chr13	92345689	92345689	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acagttccctggaatactcaGaatgcatccggatggctcgc	10	12	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:92345689G>A	uc010tif.1	+	3	940	c.574G>A	c.(574-576)GAA>AAA	p.E192K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	192						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GGAATACTCAGAATGCATCCG	0.483													0	0	0	0.01441	0	57	111										A	92345689	G	A	92345689	3	1	105	1	0	0	0	0	1	0	0	0	6601	943	33	1	584	1	GPC5	13	92345689	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7890587	92345689	22824189	284	32431										
ZIC2	7546	broad.mit.edu	37	chr13	100634397	100634397	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	accatcaccactccgccgcgGcggcggcggcggctgccgcc	14	20	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:100634397G>A	uc001von.2	+	1	79	c.79G>A	c.(79-81)GCG>ACG	p.A27T		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	27	Poly-Ala.				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CTccgccgcggcggcggcggc	0.612													0	0	0	0.014758	0	4	4										A	100634397	G	A	100634397	3	1	105	1	0	0	0	0	1	0	0	0	17676	1203	42	2	81	2	ZIC2	13	100634397	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	8288708	100634397	14535481	285	32432										
MYO16	23026	broad.mit.edu	37	chr13	109858981	109858981	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tccatcagctgaggctctcaGagaatgaaagtgtggccctg	12	10	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr13:109858981G>C	uc001vqt.1	+	35	5500	c.5374G>C	c.(5374-5376)GAG>CAG	p.E1792Q	MYO16_uc010agk.1_Missense_Mutation_p.E1814Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1792					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GAGGCTCTCAGAGAATGAAAG	0.512													0	0	0	0.00499	0	18	100										C	109858981	G	C	109858981	3	2	105	1	0	0	0	0	1	0	0	0	10064	943	33	1	5508	1	MYO16	13	109858981	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	9224584	109858981	5310897	286	32433										
ARHGAP5	394	broad.mit.edu	37	chr14	32562753	32562753	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atacaagggaatcaacccatCaaagtgaagatgtttttcta	7	7	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:32562753C>G	uc001wrl.2	+	2	3117	c.2878C>G	c.(2878-2880)CAA>GAA	p.Q960E	ARHGAP5_uc001wrm.2_Missense_Mutation_p.Q960E|ARHGAP5_uc001wrn.2_Missense_Mutation_p.Q960E|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	960					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATCAACCCATCAAAGTGAAGA	0.358													0	0	0	0.01441	0	53	44										G	32562753	C	G	32562753	3	3	105	1	0	0	0	0	1	0	0	0	886	827	29	1	2880	1	ARHGAP5	14	32562753	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		32562753	74786787	287	32434										
INSM2	84684	broad.mit.edu	37	chr14	36004326	36004326	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctcccgcatcgtgcgcgtaGagtaccgctgccctgagtgc	13	15	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:36004326G>C	uc001wth.1	+	1	1079	c.868G>C	c.(868-870)GAG>CAG	p.E290Q		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		CGTGCGCGTAGAGTACCGCTG	0.672													0	0	0	0.010504	0	21	27										C	36004326	G	C	36004326	3	2	105	1	0	0	0	0	1	0	0	0	7772	943	33	1	870	1	INSM2	14	36004326	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3441573	36004326	71345214	288	32435										
KLHL28	54813	broad.mit.edu	37	chr14	45414407	45414407	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcgatcatcacgaataagaTgatttgcttcatatagtcta	7	7	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:45414407T>C	uc001wvq.2	-	2	971	c.725A>G	c.(724-726)CAT>CGT	p.H242R	KLHL28_uc001wvr.2_Missense_Mutation_p.H242R|KLHL28_uc001wvt.3_Missense_Mutation_p.H242R	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	242										ovary(1)	1						ACGAATAAGATGATTTGCTTC	0.373													0	0	0	0.016522	0	24	66										C	45414407	T	C	45414407	3	2	105	1	0	0	0	0	1	0	0	0	8382	1464	51	5	1006	5	KLHL28	14	45414407	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	9410081	45414407	61935133	289	32436										
HSPA2	3306	broad.mit.edu	37	chr14	65008896	65008896	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaccagagcagcgtactggtGcaggtatacgagggcgaacg	15	9	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:65008896G>A	uc001xhj.2	+	2	1405	c.1329G>A	c.(1327-1329)GTG>GTA	p.V443V	HSPA2_uc001xhk.3_Silent_p.V443V	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	443					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		GCGTACTGGTGCAGGTATACG	0.607													0	0	0	0.013537	0	13	82										A	65008896	G	A	65008896	2	1	105	1	0	0	0	0	0	0	0	1	7411	1306	46	2		2	HSPA2	14	65008896	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	19594489	65008896	42340644	290	32437										
PLEKHG3	26030	broad.mit.edu	37	chr14	65197646	65197646	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagccagtccagcgcatcctCaagtaccacctgctgctcca	7	17	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:65197646C>G	uc001xho.1	+	6	965	c.696C>G	c.(694-696)CTC>CTG	p.L232L	PLEKHG3_uc001xhn.1_Silent_p.L176L|PLEKHG3_uc001xhp.2_Silent_p.L232L|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	232	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		AGCGCATCCTCAAGTACCACC	0.642													0	0	0	0.010504	0	21	66										G	65197646	C	G	65197646	2	3	105	1	0	0	0	0	0	0	0	1	12070	813	29	1		1	PLEKHG3	14	65197646	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	188750	65197646	42151894	291	32438										
MPP5	64398	broad.mit.edu	37	chr14	67787792	67787792	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agatacaacccggagtaggcGagaccaagaagtagccggta	13	9	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:67787792G>A	uc001xjc.2	+	13	2022	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	MPP5_uc001xjd.2_Missense_Mutation_p.R485Q|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	519	Guanylate kinase-like.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		CGGAGTAGGCGAGACCAAGAA	0.448													0	0	0	0.00623	0	39	71										A	67787792	G	A	67787792	3	1	105	1	0	0	0	0	1	0	0	0	9737	1058	37	1	1598	1	MPP5	14	67787792	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2590146	67787792	39561748	292	32439										
GOLGA5	9950	broad.mit.edu	37	chr14	93273263	93273263	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgaagttcagtctttaaatCaagaaatggcctcgttactc	7	8	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:93273263C>G	uc001yaz.1	+	3	909	c.727C>G	c.(727-729)CAA>GAA	p.Q243E		NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	243	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		GTCTTTAAATCAAGAAATGGC	0.378			T	RET	papillary thyroid								0	0	0	0.016723	0	14	70										G	93273263	C	G	93273263	3	3	105	1	0	0	0	0	1	0	0	0	6556	827	29	1	733	1	GOLGA5	14	93273263	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	25485471	93273263	14076277	293	32440										
KIAA1409	57578	broad.mit.edu	37	chr14	94156520	94156520	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgttgtcctggctgctgctGggttccctcactcacaatgc	10	14	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:94156520G>A	uc001ybv.1	+	44	6878	c.6795G>A	c.(6793-6795)CTG>CTA	p.L2265L	KIAA1409_uc001ybs.1_Silent_p.L2243L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2420						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GGCTGCTGCTGGGTTCCCTCA	0.473													0	0	0	0.006999	0	41	63										A	94156520	G	A	94156520	2	1	105	1	0	0	0	0	0	0	0	1	8230	1335	47	2		2	KIAA1409	14	94156520	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	883257	94156520	13193020	294	32441										
DDX24	57062	broad.mit.edu	37	chr14	94528602	94528602	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atttccagtctgctctttatCaagattttcctcctcattct	3	12	5	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:94528602C>T	uc001ycj.2	-	3	1183	c.1084G>A	c.(1084-1086)GAT>AAT	p.D362N	DDX24_uc010twq.1_Missense_Mutation_p.D319N|DDX24_uc010twr.1_Missense_Mutation_p.D112N	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	362	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TGCTCTTTATCAAGATTTTCC	0.483													0	0	0	0.01441	0	50	105										T	94528602	C	T	94528602	3	4	105	1	0	0	0	0	1	0	0	0	4351	826	29	1	1523	1	DDX24	14	94528602	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	372082	94528602	12820938	295	32442										
EML1	2009	broad.mit.edu	37	chr14	100380990	100380990	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgacaagcatgccactctcTgggacgctgtgggtcaccgt	12	12	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:100380990T>C	uc001ygs.2	+	15	1777	c.1708T>C	c.(1708-1710)TGG>CGG	p.W570R	EML1_uc010tww.1_Missense_Mutation_p.W558R|EML1_uc001ygr.2_Missense_Mutation_p.W589R	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	570	WD 6.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				TGCCACTCTCTGGGACGCTGT	0.463													0	0	0	0.00499	0	18	36										C	100380990	T	C	100380990	3	2	105	1	0	0	0	0	1	0	0	0	5096	1580	55	5	1827	5	EML1	14	100380990	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	5852388	100380990	6968550	296	32443										
CDC42BPB	9578	broad.mit.edu	37	chr14	103465928	103465928	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acgtaatgaagctgatggatGgagtcaatggccagcaccat	12	8	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:103465928G>A	uc001ymi.1	-	5	802	c.570C>T	c.(568-570)TCC>TCT	p.S190S		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	190	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GCTGATGGATGGAGTCAATGG	0.448													0	0	0	0.01441	0	54	85										A	103465928	G	A	103465928	2	1	105	1	0	0	0	0	0	0	0	1	3073	1335	47	2		2	CDC42BPB	14	103465928	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3084938	103465928	3883612	297	32444										
XRCC3	7517	broad.mit.edu	37	chr14	104165252	104165252	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agggtccgggctgggcagccGagggcagcctcttcctcgcg	17	14	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:104165252G>A	uc001yny.3	-	10	1304	c.924C>T	c.(922-924)CTC>CTT	p.L308L	KLC1_uc010tyf.1_Intron|KLC1_uc001yno.2_Intron|KLC1_uc001yns.2_Intron|XRCC3_uc001ynx.3_Silent_p.L308L|XRCC3_uc001ynz.3_Silent_p.L308L|XRCC3_uc001yoa.3_Silent_p.L308L	NM_005432	NP_005423	O43542	XRCC3_HUMAN	X-ray repair cross complementing protein 3	308					DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		CTGGGCAGCCGAGGGCAGCCT	0.672								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.001984	0	7	5										A	104165252	G	A	104165252	2	1	105	1	0	0	0	0	0	0	0	1	17451	1045	37	1		1	XRCC3	14	104165252	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	699324	104165252	3184288	298	32445										
KIAA0284	283638	broad.mit.edu	37	chr14	105360120	105360120	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gatcttcgataacctgatgcTgaacccggtgtcccagctgt	10	12	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:105360120T>C	uc010axb.2	+	16	4429	c.4205T>C	c.(4204-4206)CTG>CCG	p.L1402P	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.L1332P|KIAA0284_uc001yps.2_Missense_Mutation_p.L1343P|KIAA0284_uc001ypt.2_Missense_Mutation_p.L70P	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1437						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		AACCTGATGCTGAACCCGGTG	0.657													0	0	0	0.006214	0	10	12										C	105360120	T	C	105360120	3	2	105	1	0	0	0	0	1	0	0	0	8166	1580	55	5	4263	5	KIAA0284	14	105360120	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1194868	105360120	1989420	299	32446										
CDCA4	55038	broad.mit.edu	37	chr14	105477759	105477759	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcagctggggtttttagtctCcagcgtttcaaatatctgat	10	8	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:105477759C>G	uc001yqa.2	-	2	604	c.508G>C	c.(508-510)GAG>CAG	p.E170Q	CDCA4_uc001yqb.2_Missense_Mutation_p.E170Q	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	170						nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		TTTTTAGTCTCCAGCGTTTCA	0.547													0	0	0	0.004482	0	7	70										G	105477759	C	G	105477759	3	3	105	1	0	0	0	0	1	0	0	0	3088	864	30	1	221	1	CDCA4	14	105477759	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	117639	105477759	1871781	300	32447										
BRF1	2972	broad.mit.edu	37	chr14	105685546	105685546	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacagctcggccttcacgcgGgcttccgactcattcaggat	10	15	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr14:105685546G>C	uc001yqp.2	-	13	1764	c.1401C>G	c.(1399-1401)GCC>GCG	p.A467A	BRF1_uc010tyo.1_Silent_p.A352A|BRF1_uc010typ.1_Silent_p.A374A|BRF1_uc001yqk.2_5'UTR|BRF1_uc001yql.2_Silent_p.A263A|BRF1_uc001yqo.2_Silent_p.A229A|BRF1_uc010axg.1_Silent_p.A440A|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron|BRF1_uc010axi.1_5'UTR	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	467					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		CCTTCACGCGGGCTTCCGACT	0.647													0	0	0	0.015359	0	32	57										C	105685546	G	C	105685546	2	2	105	1	0	0	0	0	0	0	0	1	1510	1219	43	4		4	BRF1	14	105685546	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	207787	105685546	1663994	301	32448										
APBA2	321	broad.mit.edu	37	chr15	29400577	29400577	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagtaccagctgggcttcagCgtgcagaatggaattgtgag	14	7	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:29400577C>T	uc001zck.2	+	12	2229	c.2022C>T	c.(2020-2022)AGC>AGT	p.S674S	APBA2_uc010azj.2_Silent_p.S662S|APBA2_uc010uat.1_Silent_p.S662S|APBA2_uc001zcl.2_Silent_p.S662S	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	674	PDZ 2.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGGGCTTCAGCGTGCAGAATG	0.607													0	0	0	0.00632	0	27	90										T	29400577	C	T	29400577	2	4	105	1	0	0	0	0	0	0	0	1	757	767	27	2		2	APBA2	15	29400577	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		29400577	73130815	302	32449										
FSIP1	161835	broad.mit.edu	37	chr15	39910077	39910077	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtcttcgacataaaatagtCttttgtgtcactaataataa	5	6	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:39910077C>T	uc001zki.2	-	11	1776	c.1558G>A	c.(1558-1560)GAC>AAC	p.D520N		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	520										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		ATAAAATAGTCTTTTGTGTCA	0.408													0	0	0	0.01441	0	55	52										T	39910077	C	T	39910077	3	4	105	1	0	0	0	0	1	0	0	0	6074	913	32	1	195	1	FSIP1	15	39910077	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10509500	39910077	62621315	303	32450										
EIF2AK4	440275	broad.mit.edu	37	chr15	40268620	40268620	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctggctgtgccgcaggtgcaGaacaagttggacggctgctg	16	10	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:40268620G>A	uc001zkm.1	+	12	1874	c.1824G>A	c.(1822-1824)CAG>CAA	p.Q608Q	EIF2AK4_uc010bbj.1_Silent_p.Q337Q	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	608	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CGCAGGTGCAGAACAAGTTGG	0.617													0	0	0	0.012319	0	22	20										A	40268620	G	A	40268620	2	1	105	1	0	0	0	0	0	0	0	1	4999	933	33	1		1	EIF2AK4	15	40268620	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	358543	40268620	62262772	304	32451										
INO80	54617	broad.mit.edu	37	chr15	41319809	41319809	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cttactcgtggactggccacAcacaaaaaagatggcagctc	9	12	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:41319809A>G	uc001zni.2	-	25	3246	c.3033T>C	c.(3031-3033)TGT>TGC	p.C1011C	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1011	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						GACTGGCCACACACAAAAAAG	0.473													0	0	0	0.016723	0	13	37										G	41319809	A	G	41319809	2	3	105	1	0	0	0	0	0	0	0	1	7746	157	6	5		5	INO80	15	41319809	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	1051189	41319809	61211583	305	32452										
MGA	23269	broad.mit.edu	37	chr15	42003336	42003336	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaataactttgttgtgccaaCtttggatgaaaatatatttc	7	5	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:42003336C>G	uc001zog.1	+	8	2964	c.2873C>G	c.(2872-2874)ACT>AGT	p.T958S	MGA_uc010ucy.1_Missense_Mutation_p.T958S|MGA_uc010ucz.1_Missense_Mutation_p.T958S	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	958						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GTTGTGCCAACTTTGGATGAA	0.433													0	0	0	0.004656	0	25	101										G	42003336	C	G	42003336	3	3	105	1	0	0	0	0	1	0	0	0	9540	565	20	4	2899	4	MGA	15	42003336	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	683527	42003336	60528056	306	32453										
PLA2G4D	283748	broad.mit.edu	37	chr15	42374548	42374548	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caggggcacagtgaggtaccCagctgagttgtccccattcc	12	13	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:42374548C>T	uc001zox.2	-	9	807	c.712G>A	c.(712-714)GGG>AGG	p.G238R		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	238					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GTGAGGTACCCAGCTGAGTTG	0.448													0	0	0	0.007413	0	17	47										T	42374548	C	T	42374548	3	4	105	1	0	0	0	0	1	0	0	0	12004	594	21	2	1792	2	PLA2G4D	15	42374548	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	371212	42374548	60156844	307	32454										
ELL3	80237	broad.mit.edu	37	chr15	44067580	44067580	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttggaacatgggtctggcttCtaggatattttaagggaatg	13	4	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:44067580C>T	uc001zsw.1	-	6	973	c.570_splice	c.e6-1	p.R190_splice	ELL3_uc001zsv.1_Splice_Site_p.R144_splice|ELL3_uc001zsx.1_Splice_Site_p.R75_splice|uc001zsy.2_5'Flank	NM_025165	NP_079441	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3						positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				ovary(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		GGTCTGGCTTCTAGGATATTT	0.458											OREG0023092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	15	18										T	44067580	C	T	44067580	5	4	105	1	0	0	0	0	0	0	1	0	5064	927	32	1	648	1	ELL3	15	44067580	Splice_Site	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1693032	44067580	58463812	308	32455										
SEMA6D	80031	broad.mit.edu	37	chr15	48063558	48063558	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggcatcgctatactcccctcCttcaactctccccagaaata	4	17	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:48063558C>T	uc010bek.2	+	19	3158	c.2798C>T	c.(2797-2799)CCT>CTT	p.P933L	SEMA6D_uc001zvw.2_Missense_Mutation_p.P871L|SEMA6D_uc001zvy.2_Missense_Mutation_p.P933L|SEMA6D_uc001zvz.2_Missense_Mutation_p.P877L|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.P871L|SEMA6D_uc001zwc.2_Missense_Mutation_p.P858L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	933	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TACTCCCCTCCTTCAACTCTC	0.517													0	0	0	0.01441	0	48	127										T	48063558	C	T	48063558	3	4	105	1	0	0	0	0	1	0	0	0	14042	681	24	2	2911	2	SEMA6D	15	48063558	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3995978	48063558	54467834	309	32456										
ONECUT1	3175	broad.mit.edu	37	chr15	53081358	53081358	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aggaaggccgttgatgggcaCcatgccggccgaggtgggcg	19	10	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:53081358C>A	uc002aci.1	-	1	852	c.724G>T	c.(724-726)GTG>TTG	p.V242L		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	242					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		TTGATGGGCACCATGCCGGCC	0.706													1	0	4.25531e-23	0.01441	4.64996e-23	54	50										A	53081358	C	A	53081358	3	1	105	1	0	0	0	0	1	0	0	0	10868	507	18	4	681	4	ONECUT1	15	53081358	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5017800	53081358	49450034	310	32457										
DPP8	54878	broad.mit.edu	37	chr15	65782623	65782623	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agctgatctggcatcttcttCcatgttggctagctctagac	9	11	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:65782623C>G	uc002aov.2	-	6	2356	c.778G>C	c.(778-780)GAA>CAA	p.E260Q	DPP8_uc002aow.2_Missense_Mutation_p.E260Q|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.E244Q|DPP8_uc002aoy.2_Missense_Mutation_p.E260Q|DPP8_uc002aoz.2_Missense_Mutation_p.E244Q|DPP8_uc010bhj.2_Missense_Mutation_p.E260Q|DPP8_uc002apa.2_Missense_Mutation_p.E157Q|DPP8_uc010bhk.1_Missense_Mutation_p.E2Q	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	260					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						GCATCTTCTTCCATGTTGGCT	0.353													0	0	0	0.008291	0	11	54										G	65782623	C	G	65782623	3	3	105	1	0	0	0	0	1	0	0	0	4732	864	30	1	1978	1	DPP8	15	65782623	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	12701265	65782623	36748769	311	32458										
DIS3L	115752	broad.mit.edu	37	chr15	66587330	66587330	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgaattatgtttcagatggGaaactcttgtctagtgatgt	10	4	3	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:66587330G>A	uc010ujm.1	+	2	159	c.144G>A	c.(142-144)GGG>GGA	p.G48G	DIS3L_uc010ujl.1_5'UTR|DIS3L_uc002app.2_5'UTR|DIS3L_uc002apq.2_Silent_p.G48G|DIS3L_uc010bho.2_5'UTR	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	48					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						TTTCAGATGGGAAACTCTTGT	0.368													0	0	0	0.016723	0	14	25										A	66587330	G	A	66587330	2	1	105	1	0	0	0	0	0	0	0	1	4536	1161	41	1		1	DIS3L	15	66587330	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	804707	66587330	35944062	312	32459										
DIS3L	115752	broad.mit.edu	37	chr15	66587451	66587451	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttttcatgcagacagcttgtCaagctgtgcagcatcaaaga	9	9	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:66587451C>G	uc010ujm.1	+	2	280	c.265C>G	c.(265-267)CAA>GAA	p.Q89E	DIS3L_uc010ujl.1_5'UTR|DIS3L_uc002app.2_Missense_Mutation_p.Q6E|DIS3L_uc002apq.2_Missense_Mutation_p.Q89E|DIS3L_uc010bho.2_5'UTR	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	89					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						GACAGCTTGTCAAGCTGTGCA	0.433													0	0	0	0.007291	0	28	68										G	66587451	C	G	66587451	3	3	105	1	0	0	0	0	1	0	0	0	4536	827	29	1	271	1	DIS3L	15	66587451	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	121	66587451	35943941	313	32460										
HCN4	10021	broad.mit.edu	37	chr15	73615332	73615332	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcactcgggaaggttcttggGgggcctgggctgtggccagg	20	9	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:73615332G>A	uc002avp.2	-	8	4096	c.3102C>T	c.(3100-3102)CCC>CCT	p.P1034P		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	1034	Pro-rich.|Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		AGGTTCTTGGGGGGCCTGGGC	0.721													0	0	0	0.004672	0	3	3										A	73615332	G	A	73615332	2	1	105	1	0	0	0	0	0	0	0	1	6999	1219	43	2		2	HCN4	15	73615332	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	7027881	73615332	28916060	314	32461										
CCDC33	80125	broad.mit.edu	37	chr15	74628313	74628317	+	Frame_Shift_Del	DEL	GCCCC	GCCCC	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagcagccctcagagctggaGcccctgctgcccagctcaga							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:74628313_74628317delGCCCC	uc002axo.2	+	19	2581_2585	c.2187_2191delGCCCC	c.(2185-2193)GAGCCCCTGfs	p.E729fs	CCDC33_uc002axp.2_Intron|CCDC33_uc002axq.2_3'UTR|CCDC33_uc002axr.2_3'UTR	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	932_934							protein binding			ovary(3)|skin(2)	5						CAGAGCTGGAGCCCCTGCTGCCCAG	0.634																		22	65	---	---								-	74628317	GCCCC	-	74628313	7	5	105	1	0	1	0	1	0	0	0	0	2806	962	34	0	2524	0	CCDC33	15	74628313	Frame_Shift_Del	DEL	GCCCC	TCGA-GC-A3RC-01A-11D-A22Z-08	1012981	74628313	27903079	315	32462										
ARID3B	10620	broad.mit.edu	37	chr15	74836783	74836783	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caaggcctcaccttctgtctCcacagcaggacagccgaact	8	16	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:74836783C>T	uc002aye.2	+	2	707	c.506C>T	c.(505-507)TCC>TTC	p.S169F	ARID3B_uc002ayc.2_Missense_Mutation_p.S169F|ARID3B_uc002ayd.2_Missense_Mutation_p.S169F	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						CCTTCTGTCTCCACAGCAGGA	0.522													0	0	0	0.013537	0	11	30										T	74836783	C	T	74836783	3	4	105	1	0	0	0	0	1	0	0	0	917	855	30	1	508	1	ARID3B	15	74836783	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	208470	74836783	27694609	316	32463										
C15orf39	56905	broad.mit.edu	37	chr15	75498410	75498410	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atggcagagaagcgacccctGagaaccctggggcctgtgat	14	11	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:75498410G>A	uc002azp.3	+	2	341	c.21G>A	c.(19-21)CTG>CTA	p.L7L	C15orf39_uc002azq.3_Silent_p.L7L|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	7											0						AGCGACCCCTGAGAACCCTGG	0.602													0	0	0	0.008291	0	11	8										A	75498410	G	A	75498410	2	1	105	1	0	0	0	0	0	0	0	1	1793	1277	45	1		1	C15orf39	15	75498410	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	661627	75498410	27032982	317	32464										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84539658	84539658	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggaatttcagaggggctccGagaggcaaacttttaagatt	12	6	1	3	rs139499552	by1000genomes	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr15:84539658G>A	uc002bjz.3	+	9	1131	c.907G>A	c.(907-909)GAG>AAG	p.E303K	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.E303K|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.E303K	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	303						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GAGGGGCTCCGAGAGGCAAAC	0.438													0	0	0	0.01441	0	55	42										A	84539658	G	A	84539658	3	1	105	1	0	0	0	0	1	0	0	0	276	1059	37	1	937	1	ADAMTSL3	15	84539658	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	9041248	84539658	17991734	318	32465										
HBA2	3040	broad.mit.edu	37	chr16	227392	227392	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcttctgtgagcaccgtgctGacctccaaataccgttaagc	9	13	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:227392G>A	uc002cfw.2	+	3	477	c.411G>A	c.(409-411)CTG>CTA	p.L137L	HBA1_uc002cfx.1_Silent_p.L137L|HBA1_uc002cfy.1_Silent_p.L105L|HBQ1_uc002cfz.2_5'Flank	NM_000558	NP_000549	P69905	HBA_HUMAN	alpha 1 globin	137			L -> P (in Bibba; unstable; causes alpha- thalassemia).|L -> M (in Chicago).|L -> R (in Toyama).		hydrogen peroxide catabolic process|positive regulation of cell death|protein heterooligomerization	cytosolic small ribosomal subunit|haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)			Amodiaquine(DB00613)|Chloroquine(DB00608)|Iron Dextran(DB00893)|Mefloquine(DB00358)|Primaquine(DB01087)|Quinine(DB00468)	GCACCGTGCTGACCTCCAAAT	0.672											OREG0003687	type=REGULATORY REGION|Gene=SERPINB9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.00308	0	8	10										A	227392	G	A	227392	2	1	105	1	0	0	0	0	0	0	0	1	6977	1277	45	1		1	HBA2	16	227392	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		227392	90127361	319	32466										
RHBDL1	9028	broad.mit.edu	37	chr16	726418	726418	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccatgagctgcccctggaccCggccaagctggacatgctgg	13	15	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:726418C>T	uc002cis.1	+	1	344	c.317C>T	c.(316-318)CCG>CTG	p.P106L	RHBDL1_uc002cir.1_Missense_Mutation_p.P41L|RHBDL1_uc010uun.1_Missense_Mutation_p.P41L	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	106					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				CCCCTGGACCCGGCCAAGCTG	0.667													0	0	0	0.014758	0	5	4										T	726418	C	T	726418	3	4	105	1	0	0	0	0	1	0	0	0	13321	652	23	2	319	2	RHBDL1	16	726418	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	499026	726418	89628335	320	32467										
MAPK8IP3	23162	broad.mit.edu	37	chr16	1817831	1817831	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggcaagctgggtttctccttCgtacgcatcacggccctgct	11	14	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:1817831C>T	uc002cmk.2	+	28	3552	c.3432C>T	c.(3430-3432)TTC>TTT	p.F1144F	MAPK8IP3_uc002cml.2_Silent_p.F1138F|MAPK8IP3_uc010uvl.1_Silent_p.F1145F	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1144					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						GTTTCTCCTTCGTACGCATCA	0.667													0	0	0	0.004672	0	3	44										T	1817831	C	T	1817831	2	4	105	1	0	0	0	0	0	0	0	1	9286	883	31	1		1	MAPK8IP3	16	1817831	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1091413	1817831	88536922	321	32468										
CREBBP	1387	broad.mit.edu	37	chr16	3807879	3807879	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgctcaaagacctctgcaagCttactgcaaaacttatagac	6	11	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:3807879C>G	uc002cvv.2	-	18	3744	c.3540G>C	c.(3538-3540)AAG>AAC	p.K1180N	CREBBP_uc002cvw.2_Missense_Mutation_p.K1142N	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1180					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCTCTGCAAGCTTACTGCAAA	0.473			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.016522	0	24	18										G	3807879	C	G	3807879	3	3	105	1	0	0	0	0	1	0	0	0	3861	796	28	4	3844	4	CREBBP	16	3807879	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1990048	3807879	86546874	322	32469										
GRIN2A	2903	broad.mit.edu	37	chr16	9923389	9923389	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgacagcgaagaaggcccatAcagataccatgatcttgctg	10	10	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:9923389A>G	uc002czo.3	-	9	2446	c.1898T>C	c.(1897-1899)GTA>GCA	p.V633A	GRIN2A_uc010uym.1_Missense_Mutation_p.V633A|GRIN2A_uc010uyn.1_Missense_Mutation_p.V476A|GRIN2A_uc002czr.3_Missense_Mutation_p.V633A	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	633	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAAGGCCCATACAGATACCAT	0.493													0	0	0	0.010771	0	46	16										G	9923389	A	G	9923389	3	3	105	1	0	0	0	0	1	0	0	0	6779	391	14	5	2516	5	GRIN2A	16	9923389	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	6115510	9923389	80431364	323	32470										
CLEC16A	23274	broad.mit.edu	37	chr16	11051690	11051690	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acagtcacagaacagaaccgGaacctgctagtggagaccat	10	11	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:11051690G>A	uc002dao.2	+	2	362	c.132G>A	c.(130-132)CGG>CGA	p.R44R	CLEC16A_uc002dan.3_Silent_p.R44R	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	44										ovary(1)|central_nervous_system(1)	2						AACAGAACCGGAACCTGCTAG	0.428													0	0	0	0.00623	0	38	26										A	11051690	G	A	11051690	2	1	105	1	0	0	0	0	0	0	0	1	3500	1161	41	1		1	CLEC16A	16	11051690	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1128301	11051690	79303063	324	32471										
DNAH3	55567	broad.mit.edu	37	chr16	21042362	21042366	+	Splice_Site	DEL	CTTAC	CTTAC	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagtcatatcagggtcaataCttacctttttattgtcatcc							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:21042362_21042366delCTTAC	uc010vbe.1	-	37	5439	c.5439_splice	c.e37+1	p.K1813_splice		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGGGTCAATACTTACCTTTTTATTG	0.332																		32	23	---	---								-	21042366	CTTAC	-	21042362	8	5	105	1	0	1	0	1	0	0	1	0	4603	580	20	0		0	DNAH3	16	21042362	Splice_Site	DEL	CTTAC	TCGA-GC-A3RC-01A-11D-A22Z-08	9990672	21042362	69312391	325	32472										
RBBP6	5930	broad.mit.edu	37	chr16	24578652	24578652	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtttcctcctggccagccacCacccgctgggtatagtgtcc	10	16	0	0	rs144821029		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:24578652C>T	uc002dmh.2	+	15	2818	c.1778C>T	c.(1777-1779)CCA>CTA	p.P593L	RBBP6_uc010vcb.1_Missense_Mutation_p.P460L|RBBP6_uc002dmi.2_Missense_Mutation_p.P593L|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.P460L	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	593					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GGCCAGCCACCACCCGCTGGG	0.299													0	0	0	0.01441	0	145	65										T	24578652	C	T	24578652	3	4	105	1	0	0	0	0	1	0	0	0	13103	594	21	2	1890	2	RBBP6	16	24578652	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3536290	24578652	65776101	326	32473										
NSMCE1	197370	broad.mit.edu	37	chr16	27246541	27246541	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcatcttccgtgactcctctCtttatctcaatatacaagga	4	12	4	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:27246541C>T	uc002doi.1	-	3	314	c.216G>A	c.(214-216)AAG>AAA	p.K72K	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	72					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0						TGACTCCTCTCTTTATCTCAA	0.478											OREG0023693	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	34	15										T	27246541	C	T	27246541	2	4	105	1	0	0	0	0	0	0	0	1	10675	912	32	1		1	NSMCE1	16	27246541	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2667889	27246541	63108212	327	32474										
ZNF423	23090	broad.mit.edu	37	chr16	49672418	49672418	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagggcttgctggagctgtgGgtcttcaggtggatcttgag	17	6	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:49672418G>A	uc002efs.2	-	5	943	c.645C>T	c.(643-645)ACC>ACT	p.T215T	ZNF423_uc010vgn.1_Silent_p.T98T	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	215	C2H2-type 4.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TGGAGCTGTGGGTCTTCAGGT	0.592													0	0	0	0.01892	0	24	7										A	49672418	G	A	49672418	2	1	105	1	0	0	0	0	0	0	0	1	17895	1219	43	2		2	ZNF423	16	49672418	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	22425877	49672418	40682335	328	32475										
SLC12A3	6559	broad.mit.edu	37	chr16	56906306	56906306	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catcatggtctcctttgccaActatttagtggggacgctga	10	10	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:56906306A>G	uc010ccm.2	+	7	925	c.896A>G	c.(895-897)AAC>AGC	p.N299S	SLC12A3_uc002ekd.3_Missense_Mutation_p.N299S|SLC12A3_uc010ccn.2_Missense_Mutation_p.N298S	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	299	Helical; (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TCCTTTGCCAACTATTTAGTG	0.557													0	0	0	0.00499	0	16	10										G	56906306	A	G	56906306	3	3	105	1	0	0	0	0	1	0	0	0	14384	43	2	5	922	5	SLC12A3	16	56906306	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	7233888	56906306	33448447	329	32476										
CNGB1	1258	broad.mit.edu	37	chr16	57949211	57949211	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgactttcaaatagagaaaaTccaagggcaggaggctgagc	12	8	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:57949211T>C	uc002emt.2	-	23	2311	c.2246A>G	c.(2245-2247)GAT>GGT	p.D749G	CNGB1_uc010cdh.2_Missense_Mutation_p.D743G	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	749	Helical; Name=H3; (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						ATAGAGAAAATCCAAGGGCAG	0.587													0	0	0	0.004656	0	17	12										C	57949211	T	C	57949211	3	2	105	1	0	0	0	0	1	0	0	0	3600	1435	50	5	1553	5	CNGB1	16	57949211	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1042905	57949211	32405542	330	32477										
DPEP3	64180	broad.mit.edu	37	chr16	68009695	68009695	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agccactgggtgaaggttggGatggtggcagcagccacaag	17	8	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:68009695G>A	uc002evc.3	-	10	1609	c.1515C>T	c.(1513-1515)ATC>ATT	p.I505I	DPEP3_uc010cex.2_Silent_p.I504I	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	480					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TGAAGGTTGGGATGGTGGCAG	0.582													0	0	0	0.010729	0	12	3										A	68009695	G	A	68009695	2	1	105	1	0	0	0	0	0	0	0	1	4715	1164	41	1		1	DPEP3	16	68009695	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	10060484	68009695	22345058	331	32478										
ZNF276	92822	broad.mit.edu	37	chr16	89789220	89789220	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggtcaacgcctccccggctGgtcgccggaagccttgtgca	14	15	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:89789220G>A	uc002fos.3	+	2	584	c.487G>A	c.(487-489)GGT>AGT	p.G163S	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.G88S|ZNF276_uc002foq.3_Missense_Mutation_p.G88S|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCCCCGGCTGGTCGCCGGAA	0.592													0	0	0	0.007291	0	31	23										A	89789220	G	A	89789220	3	1	105	1	0	0	0	0	1	0	0	0	17808	1348	47	2	493	2	ZNF276	16	89789220	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	21779525	89789220	565533	332	32479										
DEF8	54849	broad.mit.edu	37	chr16	90015915	90015915	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcccctgggccctggcaggcGatgcaggtatgggcagacag	17	12	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr16:90015915G>A	uc002fpn.1	+	2	131	c.42G>A	c.(40-42)GCG>GCA	p.A14A	DEF8_uc002fpl.2_5'UTR|DEF8_uc002fpm.2_Intron|DEF8_uc002fpo.1_5'UTR|DEF8_uc002fpp.1_5'UTR|DEF8_uc010vpq.1_5'UTR|DEF8_uc010vpr.1_5'UTR	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	14					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CCTGGCAGGCGATGCAGGTAT	0.662													0	0	0	0.012319	0	21	24										A	90015915	G	A	90015915	2	1	105	1	0	0	0	0	0	0	0	1	4387	1045	37	1		1	DEF8	16	90015915	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	226695	90015915	338838	333	32480										
PFN1	5216	broad.mit.edu	37	chr17	4849962	4849962	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtgacattgaaggtgggggCcccaccggtgctcttggtac	15	10	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:4849962C>T	uc002gaa.2	-	2	422	c.286G>A	c.(286-288)GCC>ACC	p.A96T	PFN1_uc002fzz.2_Missense_Mutation_p.A60T	NM_005022	NP_005013	P07737	PROF1_HUMAN	profilin 1	96					actin cytoskeleton organization|platelet activation|platelet degranulation	actin cytoskeleton|cytoplasm	actin binding|proline-rich region binding				0						AAGGTGGGGGCCCCACCGGTG	0.532													0	0	0	0.016522	0	23	87										T	4849962	C	T	4849962	3	4	105	1	0	0	0	0	1	0	0	0	11767	739	26	2	144	2	PFN1	17	4849962	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		4849962	76345248	334	32481										
NLRP1	22861	broad.mit.edu	37	chr17	5445293	5445293	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtcagggtctggttggctctCagcccaaaggcaaggtcctt	13	11	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:5445293C>T	uc002gci.2	-	6	3138	c.2583G>A	c.(2581-2583)CTG>CTA	p.L861L	NLRP1_uc002gcg.1_Silent_p.L861L|NLRP1_uc002gck.2_Silent_p.L861L|NLRP1_uc002gcj.2_Silent_p.L861L|NLRP1_uc002gcl.2_Silent_p.L861L|NLRP1_uc002gch.3_Silent_p.L861L|NLRP1_uc010clh.2_Silent_p.L861L	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	861					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GGTTGGCTCTCAGCCCAAAGG	0.572													0	0	0	0.001984	0	7	22										T	5445293	C	T	5445293	2	4	105	1	0	0	0	0	0	0	0	1	10471	813	29	1		1	NLRP1	17	5445293	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	595331	5445293	75749917	335	32482										
DLG4	1742	broad.mit.edu	37	chr17	7094036	7094036	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagggcaggaatcagagtctCtctcgggctggaacccagat	13	11	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:7094036C>G	uc002get.3	-	22	3496	c.2295G>C	c.(2293-2295)GAG>GAC	p.E765D	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.E662D|DLG4_uc010cly.2_Missense_Mutation_p.E719D|DLG4_uc010vto.1_Missense_Mutation_p.E762D	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	722					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						ATCAGAGTCTCTCTCGGGCTG	0.617													0	0	0	0.013537	0	12	53										G	7094036	C	G	7094036	3	3	105	1	0	0	0	0	1	0	0	0	4557	912	32	1	12	1	DLG4	17	7094036	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1648743	7094036	74101174	336	32483										
MPDU1	9526	broad.mit.edu	37	chr17	7490058	7490058	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctccagacgatcaccatctgCttcctggtcatgcactacag	7	15	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:7490058C>T	uc002ghw.2	+	4	567	c.351C>T	c.(349-351)TGC>TGT	p.C117C	MPDU1_uc010vub.1_Silent_p.C38C|MPDU1_uc002ghx.2_Silent_p.C117C|MPDU1_uc010vuc.1_Intron	NM_004870	NP_004861	O75352	MPU1_HUMAN	mannose-P-dolichol utilization defect 1	117	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|protein folding	endoplasmic reticulum membrane|integral to membrane|mitochondrion	protein binding			central_nervous_system(1)	1						TCACCATCTGCTTCCTGGTCA	0.557													0	0	0	0.014323	0	22	61										T	7490058	C	T	7490058	2	4	105	1	0	0	0	0	0	0	0	1	9721	805	28	2		2	MPDU1	17	7490058	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	396022	7490058	73705152	337	32484										
TP53	7157	broad.mit.edu	37	chr17	7572963	7572963	+	Frame_Shift_Del	DEL	T	T	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccttctgtcttgaacatgagTtttttatggcgggaggtaga							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			T	-	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:7572963delT	uc002gim.2	-	11	1340	c.1146delA	c.(1144-1146)AAAfs	p.K382fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Frame_Shift_Del_p.K250fs|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Frame_Shift_Del_p.K382fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	382	Basic (repression of DNA-binding).|Interaction with CARM1.			K->R: Abolishes monomethylation by SETD8.|K->A: Abolishes acetylation by CREBBP.	activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.K382fs*40(3)|p.K382fs*13(2)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGAACATGAGTTTTTTATGGC	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)								62	88	---	---								-	7572963	T	-	7572963	7	5	105	1	0	1	0	1	0	0	0	0	16378	1722	60	0	39	0	TP53	17	7572963	Frame_Shift_Del	DEL	T	TCGA-GC-A3RC-01A-11D-A22Z-08	82905	7572963	73622247	338	32485										
PER1	5187	broad.mit.edu	37	chr17	8044493	8044493	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcttgaagccttggccccgcCttgggcctcctcgcagccct	11	18	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:8044493C>T	uc002gkd.2	-	23	4004	c.3766G>A	c.(3766-3768)GGC>AGC	p.G1256S	PER1_uc010cns.2_Missense_Mutation_p.G130S|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1256	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						TTGGCCCCGCCTTGGGCCTCC	0.642			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					0	0	0	0.01441	0	57	156										T	8044493	C	T	8044493	3	4	105	1	0	0	0	0	1	0	0	0	11729	681	24	2	110	2	PER1	17	8044493	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	471530	8044493	73150717	339	32486										
USP43	124739	broad.mit.edu	37	chr17	9604544	9604544	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttggatgaatgttttcagttCtacaccaaggaggagcaggt	12	6	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:9604544C>G	uc010cod.2	+	11	1644	c.1644C>G	c.(1642-1644)TTC>TTG	p.F548L	USP43_uc002gma.3_Missense_Mutation_p.F237L|USP43_uc010vva.1_Missense_Mutation_p.F548L|USP43_uc010coe.2_Missense_Mutation_p.F345L|USP43_uc002gmc.3_Missense_Mutation_p.S25C	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	548					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GTTTTCAGTTCTACACCAAGG	0.657													0	0	0	0.014758	0	4	6										G	9604544	C	G	9604544	3	3	105	1	0	0	0	0	1	0	0	0	17071	912	32	1	1686	1	USP43	17	9604544	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1560051	9604544	71590666	340	32487										
TBC1D26	353149	broad.mit.edu	37	chr17	15641362	15641362	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtggcaaaagatgcttgcaGactggacaaaatataggagc	12	6	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:15641362G>T	uc010cov.2	+	6	500	c.250G>T	c.(250-252)GAC>TAC	p.D84Y	TBC1D26_uc010cou.1_Missense_Mutation_p.D84Y|TBC1D26_uc002gpb.3_RNA	NM_178571	NP_848666	Q86UD7	TBC26_HUMAN	TBC1 domain family, member 26	84						intracellular	Rab GTPase activator activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.078)		GATGCTTGCAGACTGGACAAA	0.522													1	0	2.14674e-31	0.01441	2.36011e-31	48	49										T	15641362	G	T	15641362	3	4	105	1	0	0	0	0	1	0	0	0	15613	942	33	3	264	3	TBC1D26	17	15641362	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6036818	15641362	65553848	341	32488										
NOS2	4843	broad.mit.edu	37	chr17	26097944	26097944	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctcaagccacccacctctcCattgccagggcagtctccat	6	19	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:26097944C>T	uc002gzu.2	-	15	2068	c.1804G>A	c.(1804-1806)GGA>AGA	p.G602R	NOS2_uc010crh.1_Missense_Mutation_p.G602R|NOS2_uc010wab.1_Intron	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	602	Flavodoxin-like.				arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CCCACCTCTCCATTGCCAGGG	0.612													0	0	0	0.004482	0	8	14										T	26097944	C	T	26097944	3	4	105	1	0	0	0	0	1	0	0	0	10543	603	21	2	1709	2	NOS2	17	26097944	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	10456582	26097944	55097266	342	32489										
CORO6	84940	broad.mit.edu	37	chr17	27945821	27945821	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cactcaccgccaccacttggCcttttctggggtcaatgatg	9	14	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:27945821C>T	uc002hel.2	-	4	622	c.620G>A	c.(619-621)GGC>GAC	p.G207D	CORO6_uc002hem.2_5'Flank|CORO6_uc002hen.2_5'Flank	NM_032854	NP_116243	Q6QEF8	CORO6_HUMAN	coronin 6	207	WD 3.				actin cytoskeleton organization	actin cytoskeleton	actin filament binding				0						CACCACTTGGCCTTTTCTGGG	0.597													0	0	0	0.006214	0	10	27										T	27945821	C	T	27945821	3	4	105	1	0	0	0	0	1	0	0	0	3758	739	26	2	826	2	CORO6	17	27945821	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1847877	27945821	53249389	343	32490										
NF1	4763	broad.mit.edu	37	chr17	29557345	29557345	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgaaactgtgtcaattagttGaagtaatgatggcaaggaga	12	4	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:29557345G>A	uc002hgg.2	+	23	3391	c.3058G>A	c.(3058-3060)GAA>AAA	p.E1020K	NF1_uc002hgh.2_Missense_Mutation_p.E1020K|NF1_uc010csn.1_Missense_Mutation_p.E880K|NF1_uc002hgi.1_Missense_Mutation_p.E53K	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1020					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCAATTAGTTGAAGTAATGAT	0.333			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.013726	0	36	42										A	29557345	G	A	29557345	3	1	105	1	0	0	0	0	1	0	0	0	10356	1291	45	1	3209	1	NF1	17	29557345	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1611524	29557345	51637865	344	32491										
SYNRG	11276	broad.mit.edu	37	chr17	35914064	35914064	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gatggtggaaaagttttgtcTtttgttggtggctctagtgg	15	3	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:35914064T>A	uc002hoa.2	-	14	1844	c.1761A>T	c.(1759-1761)AAA>AAT	p.K587N	SYNRG_uc010wde.1_Missense_Mutation_p.K509N|SYNRG_uc010wdf.1_Missense_Mutation_p.K509N|SYNRG_uc002hoc.2_Missense_Mutation_p.K508N|SYNRG_uc002hoe.2_Missense_Mutation_p.K509N|SYNRG_uc002hod.2_Missense_Mutation_p.K509N|SYNRG_uc010wdg.1_Missense_Mutation_p.K426N|SYNRG_uc002hob.2_Missense_Mutation_p.K587N|SYNRG_uc002hof.2_Missense_Mutation_p.K299N|SYNRG_uc010cvd.1_Missense_Mutation_p.K387N	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	587	Interaction with A1P1G1 and A1P1G2.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						AAGTTTTGTCTTTTGTTGGTG	0.408													0	0	0	0.01441	0	79	33										A	35914064	T	A	35914064	3	1	105	1	0	0	0	0	1	0	0	0	15457	1606	56	5	2292	5	SYNRG	17	35914064	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	6356719	35914064	45281146	345	32492										
FZD2	2535	broad.mit.edu	37	chr17	42635140	42635140	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccggcccagttccacggggaGaagggcatctccatcccgga	13	15	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:42635140G>A	uc002igx.1	+	1	216	c.84G>A	c.(82-84)GAG>GAA	p.E28E		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	28	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TCCACGGGGAGAAGGGCATCT	0.567													0	0	0	0.004007	0	15	34										A	42635140	G	A	42635140	2	1	105	1	0	0	0	0	0	0	0	1	6130	933	33	1		1	FZD2	17	42635140	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6721076	42635140	38560070	346	32493										
ADAM11	4185	broad.mit.edu	37	chr17	42853520	42853520	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	accacggggtgtgtcctgccGagaggccgtgaacgagtgcg	17	11	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:42853520G>A	uc002ihh.2	+	18	1511	c.1511G>A	c.(1510-1512)CGA>CAA	p.R504Q	ADAM11_uc010wjd.1_Missense_Mutation_p.R304Q|ADAM11_uc002ihi.2_5'Flank	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	504	Extracellular (Potential).|Disintegrin.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GTGTCCTGCCGAGAGGCCGTG	0.697													0	0	0	0.01441	0	62	77										A	42853520	G	A	42853520	3	1	105	1	0	0	0	0	1	0	0	0	235	1058	37	1	1581	1	ADAM11	17	42853520	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	218380	42853520	38341690	347	32494										
KIF18B	146909	broad.mit.edu	37	chr17	43012728	43012728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtacatgatgccggggtcccCctcccttcccagcatggtgt	11	15	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:43012728C>T	uc010wji.1	-	3	471	c.370G>A	c.(370-372)GGG>AGG	p.G124R	KIF18B_uc002iht.2_Missense_Mutation_p.G124R|KIF18B_uc010wjh.1_Missense_Mutation_p.G124R	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				CCGGGGTCCCCCTCCCTTCCC	0.627													0	0	0	0.00632	0	29	19										T	43012728	C	T	43012728	3	4	105	1	0	0	0	0	1	0	0	0	8281	623	22	2	2252	2	KIF18B	17	43012728	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	159208	43012728	38182482	348	32495										
NSF	4905	broad.mit.edu	37	chr17	44788430	44788430	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctagatgatggggagctgctGgtgcagcagactaagaacag	15	7	0	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:44788430G>A	uc002iku.2	+	14	1676	c.1572G>A	c.(1570-1572)CTG>CTA	p.L524L	NSF_uc010wke.1_Silent_p.L430L|NSF_uc010wkf.1_Silent_p.L430L|NSF_uc010wkg.1_Silent_p.L519L	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	524					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		GGGAGCTGCTGGTGCAGCAGA	0.443													0	0	0	0.008361	0	28	24										A	44788430	G	A	44788430	2	1	105	1	0	0	0	0	0	0	0	1	10671	1335	47	2		2	NSF	17	44788430	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1775702	44788430	36406780	349	32496										
NFE2L1	4779	broad.mit.edu	37	chr17	46133814	46133814	+	Frame_Shift_Del	DEL	G	G	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggctgggcgtgaggtttttGactatagtcaccgccagaag							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:46133814delG	uc002imz.3	+	3	1228	c.577delG	c.(577-579)GACfs	p.D193fs	NFE2L1_uc002ina.3_Frame_Shift_Del_p.D193fs|NFE2L1_uc002inb.3_Frame_Shift_Del_p.D193fs|NFE2L1_uc010wle.1_Frame_Shift_Del_p.D35fs|NFE2L1_uc010wlf.1_Frame_Shift_Del_p.D67fs|NFE2L1_uc002inc.1_Frame_Shift_Del_p.D182fs	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	193	Asp/Glu-rich (acidic).				anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						TGAGGTTTTTGACTATAGTCA	0.547																		73	288	---	---								-	46133814	G	-	46133814	7	5	105	1	0	1	0	1	0	0	0	0	10367	1290	45	0	583	0	NFE2L1	17	46133814	Frame_Shift_Del	DEL	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1345384	46133814	35061396	350	32497										
HOXB1	3211	broad.mit.edu	37	chr17	46607197	46607197	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cttgtggtgaagttggtgcgGaggccactgggcgagcccag	18	9	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:46607197G>A	uc002ink.1	-	2	624	c.618C>T	c.(616-618)CTC>CTT	p.L206L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	206	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGTTGGTGCGGAGGCCACTGG	0.607													0	0	0	0.006999	0	38	115										A	46607197	G	A	46607197	2	1	105	1	0	0	0	0	0	0	0	1	7299	1161	41	1		1	HOXB1	17	46607197	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	473383	46607197	34588013	351	32498										
MTMR4	9110	broad.mit.edu	37	chr17	56582854	56582854	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgctaggatccggcatctggCtacacacagcccggaggtac	12	13	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:56582854C>T	uc002iwj.2	-	11	1192	c.1082G>A	c.(1081-1083)AGC>AAC	p.S361N		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	361	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGCATCTGGCTACACACAGC	0.498													0	0	0	0.010729	0	12	45										T	56582854	C	T	56582854	3	4	105	1	0	0	0	0	1	0	0	0	9946	797	28	2	2541	2	MTMR4	17	56582854	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	9975657	56582854	24612356	352	32499										
RECQL5	9400	broad.mit.edu	37	chr17	73623551	73623551	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtcagcttcgctctcgcacCgggcccggccatggaagaag	13	14	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:73623551C>A	uc010dgl.2	-	20	3083	c.2927G>T	c.(2926-2928)CGG>CTG	p.R976L	RECQL5_uc010dgk.2_Missense_Mutation_p.R949L|RECQL5_uc002jot.3_Missense_Mutation_p.R172L	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	976					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GCTCTCGCACCGGGCCCGGCC	0.632								Other_identified_genes_with_known_or_suspected_DNA_repair_function					1	0	4.17593e-13	0.007835	4.42062e-13	41	47										A	73623551	C	A	73623551	3	1	105	1	0	0	0	0	1	0	0	0	13203	652	23	4	52	4	RECQL5	17	73623551	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	17040697	73623551	7571659	353	32500										
TMC6	11322	broad.mit.edu	37	chr17	76122887	76122887	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctggggtctcagggacatcGaggatgaaggccagtggctg	17	9	1	1	rs145198906		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr17:76122887G>A	uc002juj.1	-	1	153	c.27C>T	c.(25-27)CTC>CTT	p.L9L	TMC6_uc010dhf.1_5'UTR|TMC6_uc002juk.2_Silent_p.L9L|TMC6_uc010dhg.1_Silent_p.L9L|TMC6_uc002jul.1_Silent_p.L9L|TMC6_uc002jum.3_5'Flank|TMC6_uc002jun.3_Silent_p.L9L|TMC6_uc002juo.2_Intron|TMC6_uc010wtp.1_5'Flank|TMC6_uc010wtq.1_Silent_p.L9L	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	9	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			CAGGGACATCGAGGATGAAGG	0.667									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.001984	0	6	23										A	76122887	G	A	76122887	2	1	105	1	0	0	0	0	0	0	0	1	15986	1045	37	1		1	TMC6	17	76122887	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2499336	76122887	5072323	354	32501										
NDC80	10403	broad.mit.edu	37	chr18	2578122	2578122	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gtttgaagaagaggttccaaGaatctttaaagaccttgggt	11	5	1	5			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:2578122G>A	uc002kli.2	+	5	640	c.458G>A	c.(457-459)AGA>AAA	p.R153K		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	153	Interaction with the N-terminus of CDCA1.|Nuclear localization.|Interaction with RB1.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						GAGGTTCCAAGAATCTTTAAA	0.363													0	0	0	0.01441	0	61	61										A	2578122	G	A	2578122	3	1	105	1	0	0	0	0	1	0	0	0	10242	942	33	1	472	1	NDC80	18	2578122	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		2578122	75499126	355	32502										
LAMA1	284217	broad.mit.edu	37	chr18	7013975	7013975	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcaggcccggccaccaaattTtgacttgcactggcaatggc	11	13	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:7013975T>C	uc002knm.2	-	23	3296	c.3202A>G	c.(3202-3204)AAA>GAA	p.K1068E	LAMA1_uc010wzj.1_Missense_Mutation_p.K544E	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1068	Laminin EGF-like 12.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACCAAATTTTGACTTGCAC	0.572													0	0	0	0.001168	0	5	27										C	7013975	T	C	7013975	3	2	105	1	0	0	0	0	1	0	0	0	8605	1850	64	5	6189	5	LAMA1	18	7013975	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	4435853	7013975	71063273	356	32503										
CHMP1B	57132	broad.mit.edu	37	chr18	11852005	11852005	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaggcgggcctcgacctcaaCatggagctgccgcagggcca	15	14	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:11852005C>G	uc002kqe.2	+	1	617	c.495C>G	c.(493-495)AAC>AAG	p.N165K	GNAL_uc002kqc.2_Intron|GNAL_uc010dkz.2_Intron|GNAL_uc002kqd.2_Intron	NM_020412	NP_065145	Q7LBR1	CHM1B_HUMAN	chromatin modifying protein 1B	165					cell cycle|cell division|protein transport	cytosol|late endosome membrane	protein domain specific binding				0						TCGACCTCAACATGGAGCTGC	0.627													0	0	0	0.004007	0	16	15										G	11852005	C	G	11852005	3	3	105	1	0	0	0	0	1	0	0	0	3353	477	17	4	497	4	CHMP1B	18	11852005	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4838030	11852005	66225243	357	32504										
AFG3L2	10939	broad.mit.edu	37	chr18	12358835	12358835	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttctccgacactgaagagtCcgcccatccctcggcctgtc	8	17	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:12358835C>A	uc002kqz.1	-	8	973	c.860G>T	c.(859-861)GGA>GTA	p.G287V		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	287					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	ACTGAAGAGTCCGCCCATCCC	0.547													1	0	7.07596e-05	0.006122	7.24985e-05	15	59										A	12358835	C	A	12358835	3	1	105	1	0	0	0	0	1	0	0	0	360	855	30	3	1573	3	AFG3L2	18	12358835	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	506830	12358835	65718413	358	32505										
RIOK3	8780	broad.mit.edu	37	chr18	21046190	21046190	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	taaaacaacatgcctactcaGaagaacgtcgaagtgcccgc	8	12	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:21046190G>A	uc002kui.3	+	6	1254	c.637G>A	c.(637-639)GAA>AAA	p.E213K	RIOK3_uc010dls.2_Missense_Mutation_p.E213K|RIOK3_uc010xas.1_Missense_Mutation_p.E197K|RIOK3_uc010xat.1_Silent_p.Q4Q	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	213					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TGCCTACTCAGAAGAACGTCG	0.353													0	0	0	0.010504	0	19	46										A	21046190	G	A	21046190	3	1	105	1	0	0	0	0	1	0	0	0	13379	943	33	1	659	1	RIOK3	18	21046190	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	8687355	21046190	57031058	359	32506										
CXXC1	30827	broad.mit.edu	37	chr18	47812527	47812533	+	Frame_Shift_Del	DEL	CCCTCCA	CCCTCCA	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcagggacaggcctcttgcgCcctccaccctcatcccgggg							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:47812527_47812533delCCCTCCA	uc002leq.3	-	4	1051_1057	c.318_324delTGGAGGG	c.(316-324)GGTGGAGGGfs	p.G106fs	CXXC1_uc002lep.3_5'UTR|CXXC1_uc002ler.3_Frame_Shift_Del_p.G106fs|CXXC1_uc010doy.2_Frame_Shift_Del_p.G106fs|CXXC1_uc002les.2_Frame_Shift_Del_p.G106fs	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	106_108					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GCCTCTTGCGCCCTCCACCCTCATCCC	0.638																		39	62	---	---								-	47812533	CCCTCCA	-	47812527	7	5	105	1	0	1	0	1	0	0	0	0	4097	726	26	0	1706	0	CXXC1	18	47812527	Frame_Shift_Del	DEL	CCCTCCA	TCGA-GC-A3RC-01A-11D-A22Z-08	26766337	47812527	30264721	360	32507										
MALT1	10892	broad.mit.edu	37	chr18	56390406	56390406	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctggacttcaaagtggtttCactgttggatcttactgaat	10	7	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:56390406C>T	uc002lhm.1	+	10	1403	c.1145C>T	c.(1144-1146)TCA>TTA	p.S382L	MALT1_uc002lhn.1_Missense_Mutation_p.S371L	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	382	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity	p.S371L(1)		ovary(2)|lung(1)|central_nervous_system(1)	4						AAAGTGGTTTCACTGTTGGAT	0.393			T	BIRC3	MALT								0	0	0	0.014323	0	21	34										T	56390406	C	T	56390406	3	4	105	1	0	0	0	0	1	0	0	0	9202	838	29	1	1183	1	MALT1	18	56390406	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	8577879	56390406	21686842	361	32508										
NFATC1	4772	broad.mit.edu	37	chr18	77210968	77210968	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggcagcattgactgtgccgGaatcctgaaactcagaaact	11	10	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr18:77210968G>C	uc010xfg.1	+	5	2057	c.1604G>C	c.(1603-1605)GGA>GCA	p.G535A	NFATC1_uc002lnc.1_Missense_Mutation_p.G535A|NFATC1_uc010xff.1_Missense_Mutation_p.G535A|NFATC1_uc002lnd.2_Missense_Mutation_p.G535A|NFATC1_uc002lne.2_Missense_Mutation_p.G63A|NFATC1_uc010xfh.1_Missense_Mutation_p.G535A|NFATC1_uc010xfi.1_Missense_Mutation_p.G522A|NFATC1_uc010xfj.1_Missense_Mutation_p.G63A|NFATC1_uc002lnf.2_Missense_Mutation_p.G522A|NFATC1_uc002lng.2_Missense_Mutation_p.G522A|NFATC1_uc010xfk.1_Missense_Mutation_p.G522A	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	535	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GACTGTGCCGGAATCCTGAAA	0.562													0	0	0	0.013114	0	46	81										C	77210968	G	C	77210968	3	2	105	1	0	0	0	0	1	0	0	0	10361	1174	41	1	1714	1	NFATC1	18	77210968	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	20820562	77210968	866280	362	32509										
MIDN	90007	broad.mit.edu	37	chr19	1257191	1257191	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcagccccagcgaggcctccGgcttgggcctcgacttcgag	14	16	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:1257191G>A	uc002lrp.2	+	8	1842	c.1327G>A	c.(1327-1329)GGC>AGC	p.G443S		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	443						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAGGCCTCCGGCTTGGGCCT	0.682													0	0	0	0.008361	0	29	18										A	1257191	G	A	1257191	3	1	105	1	0	0	0	0	1	0	0	0	9579	1116	39	2	1353	2	MIDN	19	1257191	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		1257191	57871792	363	32510										
EEF2	1938	broad.mit.edu	37	chr19	3982047	3982047	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttgccgttggctgggtcaaaGtacctggcaaggagaggcca	15	9	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:3982047G>A	uc002lze.2	-	6	878	c.795C>T	c.(793-795)TAC>TAT	p.Y265Y		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	265						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGGTCAAAGTACCTGGCAA	0.592													0	0	0	0.009535	0	31	29										A	3982047	G	A	3982047	2	1	105	1	0	0	0	0	0	0	0	1	4929	1024	36	2		2	EEF2	19	3982047	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2724856	3982047	55146936	364	32511										
MPND	84954	broad.mit.edu	37	chr19	4359177	4359177	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tagatgctgctggtggagttCtacaagggttcccctgacct	12	10	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:4359177C>T	uc002mae.2	+	11	1321	c.1254C>T	c.(1252-1254)TTC>TTT	p.F418F	MPND_uc010dtx.2_RNA|MPND_uc002mag.2_Silent_p.F398F|MPND_uc002maf.2_Silent_p.F448F|MPND_uc002mah.2_Silent_p.F306F|MPND_uc002mai.2_Silent_p.F307F	NM_032868	NP_116257	Q8N594	MPND_HUMAN	MPN domain containing isoform 1	418							peptidase activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGTGGAGTTCTACAAGGGTT	0.612													0	0	0	0.012213	0	31	38										T	4359177	C	T	4359177	2	4	105	1	0	0	0	0	0	0	0	1	9731	912	32	1		1	MPND	19	4359177	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	377130	4359177	54769806	365	32512										
SH3GL1	6455	broad.mit.edu	37	chr19	4366967	4366967	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atccagcttggtcccctcggCccctccgaccttctcactga	7	19	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:4366967C>A	uc002maj.2	-	2	176	c.70G>T	c.(70-72)GCC>TCC	p.A24S	SH3GL1_uc002mak.2_Missense_Mutation_p.A24S|SH3GL1_uc010xig.1_Missense_Mutation_p.A24S	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	24	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		GTCCCCTCGGCCCCTCCGACC	0.597			T	MLL	AL								1	0	1.48734e-19	0.013114	1.60585e-19	45	143										A	4366967	C	A	4366967	3	1	105	1	0	0	0	0	1	0	0	0	14250	739	26	4	1072	4	SH3GL1	19	4366967	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	7790	4366967	54762016	366	32513										
ARHGEF18	23370	broad.mit.edu	37	chr19	7518413	7518413	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cctcatcaaagatatcatctCacaagtggacgccaaggtca	7	12	5	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:7518413C>G	uc002mgi.2	+	7	1605	c.1352C>G	c.(1351-1353)TCA>TGA	p.S451*	ARHGEF18_uc010xjm.1_Nonsense_Mutation_p.S293*|ARHGEF18_uc002mgh.2_Nonsense_Mutation_p.S293*|ARHGEF18_uc002mgj.1_Nonsense_Mutation_p.S94*	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	451	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GATATCATCTCACAAGTGGAC	0.522													0	0	0	0.008871	0	21	74										G	7518413	C	G	7518413	4	3	105	1	0	0	0	0	0	1	0	0	901	838	29	1	1378	1	ARHGEF18	19	7518413	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3151446	7518413	51610570	367	32514										
YIPF2	78992	broad.mit.edu	37	chr19	11038321	11038321	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctgacctgtgaggtgtccacGtcaaagaagctctgatagta	11	9	2	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:11038321G>A	uc002mqb.2	-	4	388	c.264C>T	c.(262-264)GAC>GAT	p.D88D	YIPF2_uc002mqc.2_Silent_p.D88D|C19orf52_uc002mqd.1_5'Flank	NM_024029	NP_076934	Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	88	Cytoplasmic (Potential).					integral to membrane|transport vesicle					0						AGGTGTCCACGTCAAAGAAGC	0.517													0	0	0	0.012319	0	22	25										A	11038321	G	A	11038321	2	1	105	1	0	0	0	0	0	0	0	1	17475	1136	40	2		2	YIPF2	19	11038321	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3519908	11038321	48090662	368	32515										
TRMT1	55621	broad.mit.edu	37	chr19	13220477	13220477	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atccaggtcatggatgggctCtgcccacatggggccaccaa	12	13	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:13220477C>A	uc002mwj.2	-	10	1448	c.1198G>T	c.(1198-1200)GAG>TAG	p.E400*	TRMT1_uc010xmy.1_Nonsense_Mutation_p.E4*|TRMT1_uc002mwk.2_Nonsense_Mutation_p.E371*|TRMT1_uc002mwl.3_Nonsense_Mutation_p.E400*|TRMT1_uc010xmz.1_Nonsense_Mutation_p.E186*	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	400							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGGATGGGCTCTGCCCACATG	0.652													1	0	4.54149e-19	0.014323	4.89361e-19	21	56										A	13220477	C	A	13220477	4	1	105	1	0	0	0	0	0	1	0	0	16558	922	32	3	809	3	TRMT1	19	13220477	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2182156	13220477	45908506	369	32516										
TRMT1	55621	broad.mit.edu	37	chr19	13223540	13223540	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atctcgtggcaggcccggctCttgagggccatggccccgta	14	14	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:13223540C>A	uc002mwj.2	-	6	1099	c.849G>T	c.(847-849)AAG>AAT	p.K283N	TRMT1_uc002mwk.2_Missense_Mutation_p.K283N|TRMT1_uc002mwl.3_Missense_Mutation_p.K283N|TRMT1_uc010xmz.1_Missense_Mutation_p.K69N	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	283							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		AGGCCCGGCTCTTGAGGGCCA	0.642													1	0	1.02788e-11	0.00499	1.08599e-11	16	78										A	13223540	C	A	13223540	3	1	105	1	0	0	0	0	1	0	0	0	16558	912	32	3	1174	3	TRMT1	19	13223540	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3063	13223540	45905443	370	32517										
TRMT1	55621	broad.mit.edu	37	chr19	13226568	13226568	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cactttttgcgtgtccttctCtcctggaaccttgactgcag	8	13	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:13226568C>G	uc002mwj.2	-	3	575	c.325G>C	c.(325-327)GAG>CAG	p.E109Q	NACC1_uc002mwm.2_5'Flank|TRMT1_uc002mwk.2_Missense_Mutation_p.E109Q|TRMT1_uc002mwl.3_Missense_Mutation_p.E109Q|TRMT1_uc010xmz.1_5'UTR	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	109							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		GTGTCCTTCTCTCCTGGAACC	0.502													0	0	0	0.013114	0	45	141										G	13226568	C	G	13226568	3	3	105	1	0	0	0	0	1	0	0	0	16558	922	32	1	1710	1	TRMT1	19	13226568	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3028	13226568	45902415	371	32518										
MRI1	84245	broad.mit.edu	37	chr19	13882933	13882933	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcctcccctctctcccctgcAgggattggagtttggaatcc	10	15	1	0	rs112124892	byFrequency	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:13882933A>G	uc002mxe.2	+	6	1016	c.950_splice	c.e6-2	p.G317_splice	MRI1_uc002mxf.2_Splice_Site_p.G270_splice|C19orf53_uc002mxg.2_5'Flank	NM_001031727	NP_001026897	Q9BV20	MTNA_HUMAN	translation initiation factor eIF-2B subunit						L-methionine salvage from methylthioadenosine	cell projection|cytoplasm|nucleus	identical protein binding|S-methyl-5-thioribose-1-phosphate isomerase activity			ovary(1)	1						TCTCCCCTGCAGGGATTGGAG	0.542													0	0	0	0.013726	0	33	28										G	13882933	A	G	13882933	5	3	105	1	0	0	0	0	0	0	1	0	9770	202	7	5	1063	5	MRI1	19	13882933	Splice_Site	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	656365	13882933	45246050	372	32519										
DCAF15	90379	broad.mit.edu	37	chr19	14065247	14065247	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gatgaggacttcctctatgcAgggtgaggctgggcccaggc	16	10	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:14065247A>C	uc002mxt.2	+	2	234	c.228A>C	c.(226-228)GCA>GCC	p.A76A	PODNL1_uc010xnj.1_5'Flank|PODNL1_uc002mxs.2_5'Flank	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	76										central_nervous_system(1)	1						TCCTCTATGCAGGGTGAGGCT	0.657													0	0	0	0.006214	0	10	38										C	14065247	A	C	14065247	2	2	105	1	0	0	0	0	0	0	0	1	4267	175	7	5		5	DCAF15	19	14065247	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	182314	14065247	45063736	373	32520										
CYP4F3	4051	broad.mit.edu	37	chr19	15757870	15757874	+	Frame_Shift_Del	DEL	GTACC	GTACC	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catttatgtcagctgccattGtaccaaaggacaaggtcttc					rs150284363		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:15757870_15757874delGTACC	uc002nbj.2	+	4	402_406	c.352_356delGTACC	c.(352-357)GTACCAfs	p.V118fs	CYP4F3_uc010xok.1_Frame_Shift_Del_p.V118fs|CYP4F3_uc010xol.1_Frame_Shift_Del_p.V118fs|CYP4F3_uc010xom.1_5'UTR|CYP4F3_uc002nbk.2_Frame_Shift_Del_p.V118fs|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	118_119					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						AGCTGCCATTGTACCAAAGGACAAG	0.566																		20	79	---	---								-	15757874	GTACC	-	15757870	7	5	105	1	0	1	0	1	0	0	0	0	4190	1377	48	0	362	0	CYP4F3	19	15757870	Frame_Shift_Del	DEL	GTACC	TCGA-GC-A3RC-01A-11D-A22Z-08	1692623	15757870	43371113	374	32521										
CPAMD8	27151	broad.mit.edu	37	chr19	17132940	17132940	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttaaagatggtcacgctgatGacttcctccacgcccgcgcg	10	14	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:17132940G>A	uc002nfb.2	-	2	317	c.285C>T	c.(283-285)GTC>GTT	p.V95V		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	48						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TCACGCTGATGACTTCCTCCA	0.602													0	0	0	0.010729	0	11	8										A	17132940	G	A	17132940	2	1	105	1	0	0	0	0	0	0	0	1	3795	1277	45	1		1	CPAMD8	19	17132940	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1375070	17132940	41996043	375	32522										
CRLF1	9244	broad.mit.edu	37	chr19	18705189	18705189	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agctcgcgccgcaccggcccCgagctcggctctccgccccg	12	22	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:18705189C>G	uc010ebt.1	-	7	1274	c.1080G>C	c.(1078-1080)TCG>TCC	p.S360S		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	360					negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						GCACCGGCCCCGAGCTCGGCT	0.617													0	0	0	0.014758	0	4	7										G	18705189	C	G	18705189	2	3	105	1	0	0	0	0	0	0	0	1	3886	639	23	4		4	CRLF1	19	18705189	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1572249	18705189	40423794	376	32523										
ZNF792	126375	broad.mit.edu	37	chr19	35450251	35450251	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggaaggtttgcactgaactCagagcctttcacatatgcct	10	10	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:35450251C>T	uc002nxh.1	-	4	895	c.508G>A	c.(508-510)GAG>AAG	p.E170K		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCACTGAACTCAGAGCCTTTC	0.502													0	0	0	0.01441	0	132	188										T	35450251	C	T	35450251	3	4	105	1	0	0	0	0	1	0	0	0	18161	835	29	1	1394	1	ZNF792	19	35450251	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	16745062	35450251	23678732	377	32524										
HAMP	57817	broad.mit.edu	37	chr19	35773490	35773501	+	In_Frame_Del	DEL	AGCTCCCAGATC	AGCTCCCAGATC	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagacggcacgatggcactgAgctcccagatctgggccgct							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:35773490_35773501delAGCTCCCAGATC	uc002nyw.2	+	1	81_92	c.10_21delAGCTCCCAGATC	c.(10-21)AGCTCCCAGATCdel	p.SSQI4del		NM_021175	NP_066998	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide preproprotein	4_7					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			central_nervous_system(1)	1	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GATGGCACTGAGCTCCCAGATCTGGGCCGCTT	0.623																		32	131	---	---								-	35773501	AGCTCCCAGATC	-	35773490	7	5	105	1	0	1	0	1	0	0	0	0	6948	304	11	0	12	0	HAMP	19	35773490	In_Frame_Del	DEL	AGCTCCCAGATC	TCGA-GC-A3RC-01A-11D-A22Z-08	323239	35773490	23355493	378	32525										
DMKN	93099	broad.mit.edu	37	chr19	35993780	35993780	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctcgggtgctggggggcggGacctggttctgtggatgaaa	20	7	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:35993780G>A	uc002nzm.3	-	10	1326	c.1143C>T	c.(1141-1143)GTC>GTT	p.V381V	DMKN_uc002nzi.3_5'Flank|DMKN_uc002nzj.2_Silent_p.V55V|DMKN_uc002nzk.3_Silent_p.V28V|DMKN_uc002nzl.3_Silent_p.V94V|DMKN_uc002nzo.3_Silent_p.V370V|DMKN_uc002nzn.3_Silent_p.V340V|DMKN_uc002nzw.2_Silent_p.V37V|DMKN_uc002nzr.2_Silent_p.V37V|DMKN_uc002nzp.2_Silent_p.V75V|DMKN_uc002nzq.2_Silent_p.V57V|DMKN_uc002nzt.2_Silent_p.V28V|DMKN_uc002nzs.2_Silent_p.V28V|DMKN_uc002nzu.2_Silent_p.V28V|DMKN_uc002nzv.2_Silent_p.V28V|DMKN_uc010xsv.1_Silent_p.V28V|DMKN_uc010xsw.1_Silent_p.V77V	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	381						extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TGGGGGGCGGGACCTGGTTCT	0.607													0	0	0	0.006122	0	16	37										A	35993780	G	A	35993780	2	1	105	1	0	0	0	0	0	0	0	1	4582	1161	41	1		1	DMKN	19	35993780	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	220290	35993780	23135203	379	32526										
SHKBP1	92799	broad.mit.edu	37	chr19	41086561	41086561	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cccagtttctagtctgctacAggtgcttggggagggagtgg	16	8	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:41086561A>G	uc002oob.2	+	8	701	c.652A>G	c.(652-654)AGG>GGG	p.R218G	SHKBP1_uc002ooc.2_Missense_Mutation_p.R218G|SHKBP1_uc002ood.2_Missense_Mutation_p.R218G|SHKBP1_uc010xvl.1_Missense_Mutation_p.R141G|SHKBP1_uc002ooe.2_Missense_Mutation_p.R55G|SHKBP1_uc002oof.2_Missense_Mutation_p.R55G|SHKBP1_uc010xvm.1_Missense_Mutation_p.R55G|SHKBP1_uc010xvn.1_Missense_Mutation_p.R96G	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	218						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGTCTGCTACAGGTGCTTGGG	0.582													0	0	0	0.007291	0	30	62										G	41086561	A	G	41086561	3	3	105	1	0	0	0	0	1	0	0	0	14284	202	7	5	682	5	SHKBP1	19	41086561	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	5092781	41086561	18042422	380	32527										
CYP2A7	1549	broad.mit.edu	37	chr19	41383229	41383229	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catcttggtccggtcctcaaActtgggctgccggttcttgc	11	13	3	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:41383229A>G	uc002opm.2	-	7	1569	c.1027T>C	c.(1027-1029)TTT>CTT	p.F343L	CYP2A7_uc002opo.2_Missense_Mutation_p.F343L|CYP2A7_uc002opn.2_Missense_Mutation_p.F292L	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	343						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CGGTCCTCAAACTTGGGCTGC	0.542													0	0	0	0.01441	0	51	65										G	41383229	A	G	41383229	3	3	105	1	0	0	0	0	1	0	0	0	4163	43	2	5	469	5	CYP2A7	19	41383229	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	296668	41383229	17745754	381	32528										
MEGF8	1954	broad.mit.edu	37	chr19	42856512	42856512	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcgcctgggcctggcccggtGccacccgcgggcgacctgcc	15	19	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:42856512G>A	uc002otl.3	+	18	3688	c.3053G>A	c.(3052-3054)TGC>TAC	p.C1018Y	MEGF8_uc002otm.3_Missense_Mutation_p.C626Y	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1085	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CTGGCCCGGTGCCACCCGCGG	0.701													0	0	0	0.00308	0	8	6										A	42856512	G	A	42856512	3	1	105	1	0	0	0	0	1	0	0	0	9463	1319	46	2	3123	2	MEGF8	19	42856512	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1473283	42856512	16272471	382	32529										
ZNF222	7673	broad.mit.edu	37	chr19	44536804	44536804	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaagagcttcaaatggtcctCatatcttttggtccatcaac	7	10	4	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:44536804C>T	uc002oyc.2	+	4	1160	c.977C>T	c.(976-978)TCA>TTA	p.S326L	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Missense_Mutation_p.S366L|ZNF222_uc002oyd.2_Missense_Mutation_p.S272L	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	326	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				AAATGGTCCTCATATCTTTTG	0.413													0	0	0	0.01441	0	70	117										T	44536804	C	T	44536804	3	4	105	1	0	0	0	0	1	0	0	0	17773	838	29	1	1130	1	ZNF222	19	44536804	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1680292	44536804	14592179	383	32530										
ERCC2	2068	broad.mit.edu	37	chr19	45867687	45867687	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggcgcccccctcaccaatgTtgtgggcctcgtcgaagacc	11	16	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:45867687T>C	uc002pbj.2	-	8	760	c.713A>G	c.(712-714)AAC>AGC	p.N238S	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.N160S|ERCC2_uc002pbk.2_Missense_Mutation_p.N214S|ERCC2_uc002pbl.3_Missense_Mutation_p.N214S|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	238	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CTCACCAATGTTGTGGGCCTC	0.637			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001984	0	7	24										C	45867687	T	C	45867687	3	2	105	1	0	0	0	0	1	0	0	0	5213	1725	60	5	1690	5	ERCC2	19	45867687	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1330883	45867687	13261296	384	32531										
GPR77	27202	broad.mit.edu	37	chr19	47844630	47844630	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtgtgtggtggactacggcGgctcctccagcaccgagaat	14	11	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:47844630G>A	uc010ela.1	+	2	792	c.574G>A	c.(574-576)GGC>AGC	p.G192S	GPR77_uc002pgk.1_Missense_Mutation_p.G192S	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	192	Extracellular (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GGACTACGGCGGCTCCTCCAG	0.667													0	0	0	0.012213	0	33	45										A	47844630	G	A	47844630	3	1	105	1	0	0	0	0	1	0	0	0	6709	1116	39	2	576	2	GPR77	19	47844630	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1976943	47844630	11284353	385	32532										
GYS1	2997	broad.mit.edu	37	chr19	49496351	49496351	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggcagtgaggacatggacaAagtgcggtttaaaggcatgg	16	5	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:49496351A>C	uc002plp.2	-	1	260	c.19T>G	c.(19-21)TTG>GTG	p.L7V	GYS1_uc010xzy.1_Intron|GYS1_uc010emm.2_Missense_Mutation_p.L7V|GYS1_uc010xzz.1_5'UTR|GYS1_uc010yaa.1_RNA|RUVBL2_uc002plq.1_5'Flank|RUVBL2_uc010yab.1_5'Flank|RUVBL2_uc002plr.1_5'Flank|RUVBL2_uc002pls.1_5'Flank|RUVBL2_uc010emn.1_5'Flank|RUVBL2_uc010yac.1_5'Flank	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	7					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		GACATGGACAAAGTGCGGTTT	0.612											OREG0025612	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	58	104										C	49496351	A	C	49496351	3	2	105	1	0	0	0	0	1	0	0	0	6912	11	1	5	2258	5	GYS1	19	49496351	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	1651721	49496351	9632632	386	32533										
HRC	3270	broad.mit.edu	37	chr19	49658510	49658510	+	Translation_Start_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cccatggggacggacaggcaGcactggctccagctgcctct	13	15	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:49658510G>T	uc002pmv.2	-	1	172	c.-15C>A	c.(-17--13)TGCTG>TGATG		TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein						muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CGGACAGGCAGCACTGGCTCC	0.612													1	0	9.31168e-06	0.016723	9.6132e-06	14	13										T	49658510	G	T	49658510	1	4	105	1	0	0	0	0	0	0	0	0	7352	986	34	4		4	HRC	19	49658510	Translation_Start_Site	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	162159	49658510	9470473	387	32534										
TEAD2	8463	broad.mit.edu	37	chr19	49852004	49852004	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cacgaaggctgagaactctaCcagctgcaaccgggcggtgc	13	13	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:49852004C>T	uc002pnj.2	-	8	782	c.691G>A	c.(691-693)GTA>ATA	p.V231I	TEAD2_uc002png.2_Missense_Mutation_p.V234I|TEAD2_uc002pnh.2_Missense_Mutation_p.V235I|TEAD2_uc002pni.2_Missense_Mutation_p.V234I|TEAD2_uc010yao.1_Missense_Mutation_p.V103I|TEAD2_uc010emw.2_Missense_Mutation_p.V234I	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	231	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		GAGAACTCTACCAGCTGCAAC	0.607													0	0	0	0.01441	0	53	56										T	49852004	C	T	49852004	3	4	105	1	0	0	0	0	1	0	0	0	15736	507	18	2	672	2	TEAD2	19	49852004	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	193494	49852004	9276979	388	32535										
LIM2	3982	broad.mit.edu	37	chr19	51883515	51883515	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	taggcgcacatgtagaaaatCcctgcatgagaagaagttca	10	8	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:51883515C>G	uc002pwm.2	-	5	506	c.462G>C	c.(460-462)GGG>GGC	p.G154G	LIM2_uc002pwl.2_Silent_p.G196G	NM_001161748	NP_001155220	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa isoform	154	Helical; (Potential).				cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens				0		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		TGTAGAAAATCCCTGCATGAG	0.537													0	0	0	0.004672	0	3	22										G	51883515	C	G	51883515	2	3	105	1	0	0	0	0	0	0	0	1	8795	869	30	1		1	LIM2	19	51883515	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2031511	51883515	7245468	389	32536										
ZNF615	284370	broad.mit.edu	37	chr19	52497266	52497266	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcagtaagacgcctcttctCaatgaagccttttccacatt	6	12	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:52497266C>T	uc002pye.1	-	6	1355	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	ZNF615_uc002pyf.1_Missense_Mutation_p.E366K|ZNF615_uc002pyg.1_Missense_Mutation_p.E247K|ZNF615_uc002pyh.1_Missense_Mutation_p.E366K|ZNF615_uc010epi.1_Missense_Mutation_p.E362K|ZNF615_uc010ydg.1_Missense_Mutation_p.E360K	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	355	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CGCCTCTTCTCAATGAAGCCT	0.398													0	0	0	0.01441	0	49	101										T	52497266	C	T	52497266	3	4	105	1	0	0	0	0	1	0	0	0	18037	835	29	1	1136	1	ZNF615	19	52497266	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	613751	52497266	6631717	390	32537										
MYADM	91663	broad.mit.edu	37	chr19	54377621	54377621	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gctcgagagatgtaagctgcAgccgcagccatgcctactac	11	13	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:54377621A>C	uc002qcl.2	+	3	986	c.838A>C	c.(838-840)AGC>CGC	p.S280R	MYADM_uc002qcm.2_Missense_Mutation_p.S280R|MYADM_uc002qcn.2_Missense_Mutation_p.S280R|MYADM_uc002qco.2_Missense_Mutation_p.S280R|MYADM_uc002qcp.2_Missense_Mutation_p.S280R	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	280	MARVEL 2.					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		TGTAAGCTGCAGCCGCAGCCA	0.617													0	0	0	0.004007	0	15	52										C	54377621	A	C	54377621	3	2	105	1	0	0	0	0	1	0	0	0	10006	188	7	5	840	5	MYADM	19	54377621	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	1880355	54377621	4751362	391	32538										
CNOT3	4849	broad.mit.edu	37	chr19	54647749	54647749	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcactctctacagcaaatggAacggttcaaagttgtggaac	10	9	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:54647749A>G	uc002qdj.1	+	6	577	c.266A>G	c.(265-267)GAA>GGA	p.E89G	CNOT3_uc010yel.1_Missense_Mutation_p.E89G|CNOT3_uc002qdi.2_Missense_Mutation_p.E2G|CNOT3_uc002qdk.1_Missense_Mutation_p.E89G|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	89					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAGCAAATGGAACGGTTCAAA	0.557													0	0	0	0.012213	0	33	56										G	54647749	A	G	54647749	3	3	105	1	0	0	0	0	1	0	0	0	3620	246	9	5	284	5	CNOT3	19	54647749	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	270128	54647749	4481234	392	32539										
SLC27A5	10998	broad.mit.edu	37	chr19	59010912	59010912	+	Frame_Shift_Del	DEL	G	G	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aggaagccttcgcggtccatGgccagtacgtccccggtgtt							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr19:59010912delG	uc002qtc.2	-	7	1724	c.1614delC	c.(1612-1614)GCCfs	p.A538fs	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	538	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CGCGGTCCATGGCCAGTACGT	0.692																		33	45	---	---								-	59010912	G	-	59010912	7	5	105	1	0	1	0	1	0	0	0	0	14529	1335	47	0	474	0	SLC27A5	19	59010912	Frame_Shift_Del	DEL	G	TCGA-GC-A3RC-01A-11D-A22Z-08	4363163	59010912	118071	393	32540										
DEFB125	245938	broad.mit.edu	37	chr20	76978	76978	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catctgaggccactactcccGagactactatgccaccatct	6	16	2	2	rs140898692		TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:76978G>A	uc002wcw.2	+	2	391	c.391G>A	c.(391-393)GAG>AAG	p.E131K		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	131					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			CACTACTCCCGAGACTACTAT	0.428													0	0	0	0.01441	0	55	324										A	76978	G	A	76978	3	1	105	1	0	0	0	0	1	0	0	0	4411	1059	37	1	397	1	DEFB125	20	76978	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08		76978	62948542	394	32541										
ADAM33	80332	broad.mit.edu	37	chr20	3655249	3655249	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ggtgagcagctgctccatccGaaagatctcgtgggttgaga	14	9	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:3655249G>A	uc002wit.2	-	6	589	c.502C>T	c.(502-504)CGG>TGG	p.R168W	ADAM33_uc002wir.1_Missense_Mutation_p.R168W|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.R168W|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_Missense_Mutation_p.R180W|ADAM33_uc010zqh.1_Missense_Mutation_p.R168W	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	168	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						TGCTCCATCCGAAAGATCTCG	0.607													0	0	0	0.00632	0	29	139										A	3655249	G	A	3655249	3	1	105	1	0	0	0	0	1	0	0	0	250	1057	37	1	2007	1	ADAM33	20	3655249	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	3578271	3655249	59370271	395	32542										
SMOX	54498	broad.mit.edu	37	chr20	4168011	4168011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cggccagcgtgaggctgcccGcctcattgagatgtaccgag	14	13	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:4168011G>A	uc002wkm.1	+	7	1826	c.1625G>A	c.(1624-1626)CGC>CAC	p.R542H	SMOX_uc002wkk.1_Missense_Mutation_p.R519H|SMOX_uc002wkl.1_Missense_Mutation_p.R489H|SMOX_uc002wkn.1_Missense_Mutation_p.R177H|SMOX_uc002wkp.2_Missense_Mutation_p.R572H|SMOX_uc010zqo.1_Missense_Mutation_p.R466H|SMOX_uc002wko.1_Missense_Mutation_p.R542H	NM_175839	NP_787033	Q9NWM0	SMOX_HUMAN	spermine oxidase isoform 1	542					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)	1					Spermine(DB00127)	GAGGCTGCCCGCCTCATTGAG	0.632													0	0	0	0.010818	0	32	54										A	4168011	G	A	4168011	3	1	105	1	0	0	0	0	1	0	0	0	14803	1087	38	2	1741	2	SMOX	20	4168011	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	512762	4168011	58857509	396	32543										
PCNA	5111	broad.mit.edu	37	chr20	5098271	5098271	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcggcatatacgtgcaaattCaccagaaggcatctttacta	7	10	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:5098271C>T	uc002wlp.2	-	4	630	c.427G>A	c.(427-429)GAA>AAA	p.E143K	PCNA_uc002wlq.2_Missense_Mutation_p.E143K	NM_182649	NP_872590	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	143					cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			lung(1)	1						CGTGCAAATTCACCAGAAGGC	0.383								DNA_polymerases_(catalytic_subunits)					0	0	0	0.013726	0	29	118										T	5098271	C	T	5098271	3	4	105	1	0	0	0	0	1	0	0	0	11588	835	29	1	370	1	PCNA	20	5098271	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	930260	5098271	57927249	397	32544										
RRBP1	6238	broad.mit.edu	37	chr20	17600979	17600979	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aagttctccttttagcttctCtacaatctcttcgagatgct	5	11	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:17600979C>T	uc002wpv.1	-	19	2599	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	RRBP1_uc010zrp.1_5'Flank|RRBP1_uc002wpt.1_Missense_Mutation_p.E119K|RRBP1_uc002wpu.2_Missense_Mutation_p.E523K|RRBP1_uc002wpw.1_Missense_Mutation_p.E749K|RRBP1_uc010gcl.1_Missense_Mutation_p.E523K|RRBP1_uc010gcm.1_3'UTR	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1182	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						TTTAGCTTCTCTACAATCTCT	0.517													0	0	0	0.01441	0	56	89										T	17600979	C	T	17600979	3	4	105	1	0	0	0	0	1	0	0	0	13678	922	32	1	720	1	RRBP1	20	17600979	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	12502708	17600979	45424541	398	32545										
RRBP1	6238	broad.mit.edu	37	chr20	17602568	17602568	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	catggtctgcgcctcaatcaGacagagctgcttctccgatt	9	13	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:17602568G>C	uc002wpv.1	-	15	2227	c.1873C>G	c.(1873-1875)CTG>GTG	p.L625V	RRBP1_uc010zrp.1_5'Flank|RRBP1_uc002wpt.1_5'UTR|RRBP1_uc002wpu.2_Missense_Mutation_p.L399V|RRBP1_uc002wpw.1_Missense_Mutation_p.L625V|RRBP1_uc010gcl.1_Missense_Mutation_p.L399V|RRBP1_uc010gcm.1_Missense_Mutation_p.L78V	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1058	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						GCCTCAATCAGACAGAGCTGC	0.612													0	0	0	0.012319	0	22	76										C	17602568	G	C	17602568	3	2	105	1	0	0	0	0	1	0	0	0	13678	933	33	1	1108	1	RRBP1	20	17602568	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1589	17602568	45422952	399	32546										
CST8	10047	broad.mit.edu	37	chr20	23472362	23472362	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccattcccctggccctggtgGccaggaaagacccaaaaaag	10	14	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:23472362G>A	uc002wth.1	+	2	415	c.58G>A	c.(58-60)GCC>ACC	p.A20T		NM_005492	NP_005483	O60676	CST8_HUMAN	cystatin 8 precursor	20						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					GGCCCTGGTGGCCAGGAAAGA	0.557													0	0	0	0.01441	0	47	89										A	23472362	G	A	23472362	3	1	105	1	0	0	0	0	1	0	0	0	3978	1203	42	2	60	2	CST8	20	23472362	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	5869794	23472362	39553158	400	32547										
MAP1LC3A	84557	broad.mit.edu	37	chr20	33147580	33147580	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccacgcaggccttcttcctgCtggtgaaccagcacagcatg	10	15	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:33147580C>A	uc002xaq.1	+	4	398	c.244C>A	c.(244-246)CTG>ATG	p.L82M	MAP1LC3A_uc002xap.1_Missense_Mutation_p.L86M	NM_032514	NP_115903	Q9H492	MLP3A_HUMAN	microtubule-associated protein 1 light chain 3	82					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding				0						CTTCTTCCTGCTGGTGAACCA	0.632													1	0	1.11057e-38	0.01441	1.22344e-38	81	173										A	33147580	C	A	33147580	3	1	105	1	0	0	0	0	1	0	0	0	9230	796	28	4	314	4	MAP1LC3A	20	33147580	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	9675218	33147580	29877940	401	32548										
ACSS2	55902	broad.mit.edu	37	chr20	33507279	33507279	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gacttgtggtggcatgagctCatgcaagaggcaggggatga	17	6	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:33507279C>T	uc002xbd.2	+	8	997	c.876C>T	c.(874-876)CTC>CTT	p.L292L	ACSS2_uc002xbc.2_Silent_p.L197L|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Silent_p.L305L|ACSS2_uc002xbe.2_5'UTR|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	292					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GGCATGAGCTCATGCAAGAGG	0.557													0	0	0	0.01441	0	55	154										T	33507279	C	T	33507279	2	4	105	1	0	0	0	0	0	0	0	1	189	813	29	1		1	ACSS2	20	33507279	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	359699	33507279	29518241	402	32549										
BPI	671	broad.mit.edu	37	chr20	36937359	36937359	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atccgtgaattccagcttccCagttcccagataagcatggt	8	12	0	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:36937359C>T	uc002xib.2	+	3	347	c.285C>T	c.(283-285)CCC>CCT	p.P95P		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	95					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				TCCAGCTTCCCAGTTCCCAGA	0.448													0	0	0	0.01441	0	51	107										T	36937359	C	T	36937359	2	4	105	1	0	0	0	0	0	0	0	1	1490	581	21	2		2	BPI	20	36937359	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3430080	36937359	26088161	403	32550										
SLC32A1	140679	broad.mit.edu	37	chr20	37353467	37353467	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgttcgccaggatgggttttCaggcggccacggatgaggag	17	8	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:37353467C>T	uc002xjc.2	+	1	363	c.100C>T	c.(100-102)CAG>TAG	p.Q34*		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	34	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GATGGGTTTTCAGGCGGCCAC	0.632													0	0	0	0.008871	0	19	19										T	37353467	C	T	37353467	4	4	105	1	0	0	0	0	0	1	0	0	14565	827	29	1	102	1	SLC32A1	20	37353467	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	416108	37353467	25672053	404	32551										
CHD6	84181	broad.mit.edu	37	chr20	40044106	40044106	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gggacccctctgatgagcagGagaggtccatagctgactcc	13	12	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:40044106G>C	uc002xka.1	-	34	6837	c.6659C>G	c.(6658-6660)TCC>TGC	p.S2220C	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2220					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGATGAGCAGGAGAGGTCCAT	0.612													0	0	0	0.003163	0	16	31										C	40044106	G	C	40044106	3	2	105	1	0	0	0	0	1	0	0	0	3329	1174	41	1	1504	1	CHD6	20	40044106	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2690639	40044106	22981414	405	32552										
DNTTIP1	116092	broad.mit.edu	37	chr20	44430092	44430092	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atcgaggaagcccccttcctAaaaaggtaaaccatttcctt	6	12	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:44430092A>G	uc002xpk.2	+	6	561	c.493A>G	c.(493-495)AAA>GAA	p.K165E		NM_052951	NP_443183	Q9H147	TDIF1_HUMAN	terminal deoxynucleotidyltransferase interacting	165	Nuclear localization signal (Potential).					nucleus				ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(115;0.0122)				CCCCCTTCCTAAAAAGGTAAA	0.378													0	0	0	0.014323	0	22	120										G	44430092	A	G	44430092	3	3	105	1	0	0	0	0	1	0	0	0	4681	363	13	5	515	5	DNTTIP1	20	44430092	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	4385986	44430092	18595428	406	32553										
ADNP	23394	broad.mit.edu	37	chr20	49510909	49510909	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaagtctttttgtctgcattGaaggtacagtaggggcaatt	11	5	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:49510909G>A	uc002xvt.1	-	5	687	c.342C>T	c.(340-342)TTC>TTT	p.F114F	ADNP_uc002xvu.1_Silent_p.F114F	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	114	C2H2-type 2; atypical.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TGTCTGCATTGAAGGTACAGT	0.393													0	0	0	0.010771	0	43	115										A	49510909	G	A	49510909	2	1	105	1	0	0	0	0	0	0	0	1	323	1281	45	1		1	ADNP	20	49510909	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	5080817	49510909	13514611	407	32554										
BCAS1	8537	broad.mit.edu	37	chr20	52645077	52645077	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cttgaagaatttgtcaaaaaAgctggagtccttgggcttgg	12	6	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:52645077A>T	uc002xws.2	-	4	915	c.577T>A	c.(577-579)TTT>ATT	p.F193I	BCAS1_uc010zzb.1_Missense_Mutation_p.F96I|BCAS1_uc010gim.2_Missense_Mutation_p.F96I|BCAS1_uc002xwt.2_Missense_Mutation_p.F193I|BCAS1_uc010gil.1_Missense_Mutation_p.F193I|BCAS1_uc010zzc.1_Missense_Mutation_p.F96I	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	193						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TTGTCAAAAAAGCTGGAGTCC	0.562													0	0	0	0.01441	0	74	110										T	52645077	A	T	52645077	3	4	105	1	0	0	0	0	1	0	0	0	1350	72	3	5	1213	5	BCAS1	20	52645077	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	3134168	52645077	10380443	408	32555										
TFAP2C	7022	broad.mit.edu	37	chr20	55206484	55206484	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cgccgccatcaaccccctgcAccagccggcgcccacaggca	9	22	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:55206484A>G	uc002xya.2	+	2	515	c.272A>G	c.(271-273)CAC>CGC	p.H91R	TFAP2C_uc010zzi.1_5'UTR	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	91	Gln/Pro-rich (transactivation domain).				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			AACCCCCTGCACCAGCCGGCG	0.741													0	0	0	0.004672	0	3	7										G	55206484	A	G	55206484	3	3	105	1	0	0	0	0	1	0	0	0	15786	159	6	5	278	5	TFAP2C	20	55206484	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	2561407	55206484	7819036	409	32556										
LSM14B	149986	broad.mit.edu	37	chr20	60706476	60706476	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acccagagtgccgaagcgccCgctgaggaagaccttctggg	14	13	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr20:60706476C>T	uc010gjy.1	+	7	1106	c.900C>T	c.(898-900)CCC>CCT	p.P300P	LSM14B_uc002ybv.2_Silent_p.P274P|LSM14B_uc010zzz.1_Silent_p.P220P	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	300					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CCGAAGCGCCCGCTGAGGAAG	0.527													0	0	0	0.010504	0	21	25										T	60706476	C	T	60706476	2	4	105	1	0	0	0	0	0	0	0	1	9055	639	23	2		2	LSM14B	20	60706476	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	5499992	60706476	2319044	410	32557										
TIAM1	7074	broad.mit.edu	37	chr21	32525013	32525013	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	taccagtctcactccatcttCtagagttttaaggaattcta	5	10	4	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:32525013C>A	uc002yow.1	-	20	3779	c.3307G>T	c.(3307-3309)GAA>TAA	p.E1103*	TIAM1_uc011adk.1_Nonsense_Mutation_p.E1103*|TIAM1_uc011adl.1_Nonsense_Mutation_p.E1043*	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1103	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ACTCCATCTTCTAGAGTTTTA	0.378													1	0	9.57634e-11	0.01892	1.00784e-10	25	57										A	32525013	C	A	32525013	4	1	105	1	0	0	0	0	0	1	0	0	15887	922	32	3	1508	3	TIAM1	21	32525013	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		32525013	15604882	411	32558										
MORC3	23515	broad.mit.edu	37	chr21	37741384	37741384	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtttataaaggtgatgatgAtgatgaagatgtcatcatct	10	3	3	6			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:37741384A>G	uc002yvi.2	+	15	1794	c.1718A>G	c.(1717-1719)GAT>GGT	p.D573G		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	573					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GGTGATGATGATGATGAAGAT	0.378													0	0	0	0.011902	0	45	50										G	37741384	A	G	37741384	3	3	105	1	0	0	0	0	1	0	0	0	9703	333	12	5	1776	5	MORC3	21	37741384	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	5216371	37741384	10388511	412	32559										
HLCS	3141	broad.mit.edu	37	chr21	38139583	38139583	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcctgcggtgtctgaaacatCagcctgccgaagagggggaa	14	10	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:38139583C>T	uc010gnb.2	-	7	2656	c.1455G>A	c.(1453-1455)CTG>CTA	p.L485L	HLCS_uc002yvs.2_Silent_p.L485L	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	485					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	TCTGAAACATCAGCCTGCCGA	0.567													0	0	0	0.00245	0	14	56										T	38139583	C	T	38139583	2	4	105	1	0	0	0	0	0	0	0	1	7213	813	29	1		1	HLCS	21	38139583	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	398199	38139583	9990312	413	32560										
HMGN1	3150	broad.mit.edu	37	chr21	40715063	40715063	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagacttggcttctttctctCctgcttcatcagaggctgga	9	12	4	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:40715063C>T	uc002yxo.2	-	6	482	c.278G>A	c.(277-279)GGA>GAA	p.G93E	HMGN1_uc002yxp.2_Missense_Mutation_p.E57K|HMGN1_uc002yxq.2_Missense_Mutation_p.E57K|HMGN1_uc002yxr.2_RNA	NM_004965	NP_004956	P05114	HMGN1_HUMAN	high-mobility group nucleosome binding domain 1	93					positive regulation of transcription elongation, DNA-dependent	chromatin|cytoplasm|nucleus	DNA binding			breast(1)	1		Prostate(19;8.69e-07)				TTCTTTCTCTCCTGCTTCATC	0.368													0	0	0	0.006214	0	9	44										T	40715063	C	T	40715063	3	4	105	1	0	0	0	0	1	0	0	0	7234	855	30	1	28	1	HMGN1	21	40715063	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	2575480	40715063	7414832	414	32561										
DSCAM	1826	broad.mit.edu	37	chr21	42218552	42218552	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccgaaaggctcaccattcgcGaagctctggaacaaggagag	12	11	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:42218552G>A	uc002yyq.1	-	1	488	c.36C>T	c.(34-36)TTC>TTT	p.F12F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	12					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CACCATTCGCGAAGCTCTGGA	0.502													0	0	0	0.014758	0	5	2										A	42218552	G	A	42218552	2	1	105	1	0	0	0	0	0	0	0	1	4768	1049	37	1		1	DSCAM	21	42218552	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1503489	42218552	5911343	415	32562										
RSPH1	89765	broad.mit.edu	37	chr21	43916272	43916272	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	attctctccctcctcctccaActcctccgagcccaggtccg	5	21	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:43916272A>G	uc002zbg.2	-	1	130	c.25T>C	c.(25-27)TTG>CTG	p.L9L	SLC37A1_uc002zbh.1_RNA	NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	9					meiosis	cytosol|nucleus				ovary(1)	1						TCCTCCTCCAACTCCTCCGAG	0.657													0	0	0	0.004007	0	13	36										G	43916272	A	G	43916272	2	3	105	1	0	0	0	0	0	0	0	1	13702	40	2	5		5	RSPH1	21	43916272	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	1697720	43916272	4213623	416	32563										
DIP2A	23181	broad.mit.edu	37	chr21	47953951	47953951	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tcctggctagtgattgatggGaagcatctagccaagccccc	11	12	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr21:47953951G>A	uc002zjo.2	+	12	1647	c.1464G>A	c.(1462-1464)GGG>GGA	p.G488G	DIP2A_uc011afy.1_Silent_p.G424G|DIP2A_uc011afz.1_Silent_p.G484G|DIP2A_uc002zjl.2_Silent_p.G488G|DIP2A_uc002zjm.2_Silent_p.G488G|DIP2A_uc010gql.2_Silent_p.G445G|DIP2A_uc002zjn.2_Silent_p.G488G|DIP2A_uc002zjp.1_Silent_p.G233G	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	488					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TGATTGATGGGAAGCATCTAG	0.562													0	0	0	0.009096	0	4	16										A	47953951	G	A	47953951	2	1	105	1	0	0	0	0	0	0	0	1	4527	1161	41	1		1	DIP2A	21	47953951	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	4037679	47953951	175944	417	32564										
CLTCL1	8218	broad.mit.edu	37	chr22	19222205	19222205	+	Missense_Mutation	SNP	C	C	T													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgcataattcacaatgttatCttcctcaacacaaactgaca							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:19222205C>T	uc002zpb.2	-	7	1069	c.994G>A	c.(994-996)GAT>AAT	p.D332N	CLTCL1_uc011agv.1_Missense_Mutation_p.D332N|CLTCL1_uc011agw.1_Missense_Mutation_p.D332N	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	332	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					ACAATGTTATCTTCCTCAACA	0.502			T	NaN	ALCL								0	0	0	0.01441	0	48	30										T	19222205	C	T	19222205	3	4	105	1	0	0	0	0	1	0	0	0	3567	913	32	1	4032	1	CLTCL1	22	19222205	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		19222205	32082361	418	32565	162	2								
CLTCL1	8218	broad.mit.edu	37	chr22	19222208	19222208	+	Missense_Mutation	SNP	C	C	T													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ataattcacaatgttatcttCctcaacacaaactgacagta							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:19222208C>T	uc002zpb.2	-	7	1066	c.991G>A	c.(991-993)GAA>AAA	p.E331K	CLTCL1_uc011agv.1_Missense_Mutation_p.E331K|CLTCL1_uc011agw.1_Missense_Mutation_p.E331K	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	331	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					ATGTTATCTTCCTCAACACAA	0.507			T	NaN	ALCL								0	0	0	0.01441	0	50	31										T	19222208	C	T	19222208	3	4	105	1	0	0	0	0	1	0	0	0	3567	864	30	1	4035	1	CLTCL1	22	19222208	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	3	19222208	32082358	419	32566	162	2								
LZTR1	8216	broad.mit.edu	37	chr22	21351029	21351029	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctacggcttctacaacaaccGgctgcaggcgtactgcaagc	10	14	1	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:21351029G>T	uc002zto.2	+	19	2367	c.2264G>T	c.(2263-2265)CGG>CTG	p.R755L	LZTR1_uc002ztn.2_Missense_Mutation_p.R714L|LZTR1_uc011ahy.1_Missense_Mutation_p.R736L|LZTR1_uc002ztp.2_Missense_Mutation_p.R61L	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	755					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TACAACAACCGGCTGCAGGCG	0.617													1	0	0.00121646	0.008871	0.00123238	19	9										T	21351029	G	T	21351029	3	4	105	1	0	0	0	0	1	0	0	0	9137	1116	39	4	2338	4	LZTR1	22	21351029	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2128821	21351029	29953537	420	32567										
CABIN1	23523	broad.mit.edu	37	chr22	24572198	24572215	+	In_Frame_Del	DEL	GCAGAGGCTGCCCTGGGC	GCAGAGGCTGCCCTGGGC	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cagagccacactgctggccgGcagaggctgccctgggcaca							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:24572198_24572215delGCAGAGGCTGCCCTGGGC	uc002zzi.1	+	35	6287_6304	c.6160_6177delGCAGAGGCTGCCCTGGGC	c.(6160-6177)GCAGAGGCTGCCCTGGGCdel	p.AEAALG2054del	CABIN1_uc002zzj.1_In_Frame_Del_p.AEAALG1975del|CABIN1_uc002zzl.1_In_Frame_Del_p.AEAALG2054del|CABIN1_uc010gul.1_Intron	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2054_2059					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CTGCTGGCCGGCAGAGGCTGCCCTGGGCACAGGCGCTG	0.693																		7	2	---	---								-	24572215	GCAGAGGCTGCCCTGGGC	-	24572198	7	5	105	1	0	1	0	1	0	0	0	0	2528	1203	42	0	6294	0	CABIN1	22	24572198	In_Frame_Del	DEL	GCAGAGGCTGCCCTGGGC	TCGA-GC-A3RC-01A-11D-A22Z-08	3221169	24572198	26732368	421	32568										
SUSD2	56241	broad.mit.edu	37	chr22	24582315	24582315	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caggctggccaacaggaccgGaggtctggaggtgctgctga	17	10	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:24582315G>T	uc002zzn.1	+	10	1618	c.1574G>T	c.(1573-1575)GGA>GTA	p.G525V		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	525	VWFD.|Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						AACAGGACCGGAGGTCTGGAG	0.652													1	0	3.59834e-05	0.001168	3.70076e-05	5	19										T	24582315	G	T	24582315	3	4	105	1	0	0	0	0	1	0	0	0	15405	1174	41	3	1612	3	SUSD2	22	24582315	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	10117	24582315	26722251	422	32569										
MTMR3	8897	broad.mit.edu	37	chr22	30394794	30394794	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	aaaacgaggtggagaggatgGgttttgatatgaacaacgcc	14	5	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:30394794G>C	uc003agv.3	+	8	833	c.505G>C	c.(505-507)GGT>CGT	p.G169R	MTMR3_uc003agu.3_Missense_Mutation_p.G169R|MTMR3_uc003agw.3_Missense_Mutation_p.G169R	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	169	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			GGAGAGGATGGGTTTTGATAT	0.428													0	0	0	0.009096	0	4	12										C	30394794	G	C	30394794	3	2	105	1	0	0	0	0	1	0	0	0	9945	1232	43	4	527	4	MTMR3	22	30394794	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	5812479	30394794	20909772	423	32570										
MYH9	4627	broad.mit.edu	37	chr22	36745173	36745173	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggctcaaagccactcttgtCggaaggcacccataccagct	9	14	2	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:36745173C>G	uc003apg.2	-	2	340	c.109G>C	c.(109-111)GAC>CAC	p.D37H	MYH9_uc003api.1_Missense_Mutation_p.D37H	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	37	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCACTCTTGTCGGAAGGCACC	0.552			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.016723	0	12	18										G	36745173	C	G	36745173	3	3	105	1	0	0	0	0	1	0	0	0	10042	884	31	1	5933	1	MYH9	22	36745173	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	6350379	36745173	14559393	424	32571										
CARD10	29775	broad.mit.edu	37	chr22	37904564	37904564	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agctcctcggcccactgcagCtccccctgcacggcatgcag	10	19	0	0			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:37904564C>T	uc003asx.1	-	5	1038	c.1035G>A	c.(1033-1035)GAG>GAA	p.E345E	CARD10_uc003ast.1_RNA|CARD10_uc003asw.1_Silent_p.E59E|CARD10_uc003asy.1_Silent_p.E345E	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	345	Potential.				activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CCCACTGCAGCTCCCCCTGCA	0.697													0	0	0	0.009096	0	4	4										T	37904564	C	T	37904564	2	4	105	1	0	0	0	0	0	0	0	1	2644	796	28	2		2	CARD10	22	37904564	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1159391	37904564	13400002	425	32572										
SOX10	6663	broad.mit.edu	37	chr22	38374040	38374040	+	Frame_Shift_Del	DEL	C	C	-													0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcggccttcccgttcttccgCcgcctgggctggtacttgta							TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:38374040delC	uc003aun.1	-	3	809	c.531delG	c.(529-531)CGGfs	p.R177fs	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Frame_Shift_Del_p.R177fs	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	177						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					CGTTCTTCCGCCGCCTGGGCT	0.667																		9	10	---	---								-	38374040	C	-	38374040	7	5	105	1	0	1	0	1	0	0	0	0	14941	726	26	0	877	0	SOX10	22	38374040	Frame_Shift_Del	DEL	C	TCGA-GC-A3RC-01A-11D-A22Z-08	469476	38374040	12930526	426	32573										
FAM83F	113828	broad.mit.edu	37	chr22	40415995	40415995	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atggtggacggtgacaaagtGgccactggatcttacaggtg	15	7	1	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:40415995G>A	uc003ayk.1	+	3	856	c.762G>A	c.(760-762)GTG>GTA	p.V254V		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	254										breast(1)	1						GTGACAAAGTGGCCACTGGAT	0.587													0	0	0	0.009718	0	41	20										A	40415995	G	A	40415995	2	1	105	1	0	0	0	0	0	0	0	1	5638	1335	47	2		2	FAM83F	22	40415995	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	2041955	40415995	10888571	427	32574										
ACO2	50	broad.mit.edu	37	chr22	41913629	41913629	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	agtacctgagcaagaccggcCgggaaggtgagctggcaggg	18	9	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:41913629C>G	uc003bac.2	+	7	956	c.934C>G	c.(934-936)CGG>GGG	p.R312G	ACO2_uc003bad.2_Missense_Mutation_p.R337G	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	312					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CAAGACCGGCCGGGAAGGTGA	0.567											OREG0026588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014758	0	5	15										G	41913629	C	G	41913629	3	3	105	1	0	0	0	0	1	0	0	0	147	643	23	4	960	4	ACO2	22	41913629	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	1497634	41913629	9390937	428	32575										
SERHL2	253190	broad.mit.edu	37	chr22	42952596	42952596	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctttctcctggaatcagatgTgagaagcgggctttcgtgca	12	9	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chr22:42952596T>A	uc003bcr.2	+	6	525	c.423_splice	c.e6+2	p.D141_splice	SERHL_uc011apm.1_Intron|SERHL2_uc011apn.1_Splice_Site_p.D127_splice|SERHL2_uc010gyz.2_Splice_Site_p.D77_splice|SERHL2_uc010gyy.2_Splice_Site|SERHL2_uc011apo.1_Splice_Site|RRP7B_uc003bcs.2_RNA	NM_014509	NP_055324	Q9H4I8	SEHL2_HUMAN	serine hydrolase-like 2							perinuclear region of cytoplasm|peroxisome	hydrolase activity				0						GAATCAGATGTGAGAAGCGGG	0.562													0	0	0	0.01441	0	38	83										A	42952596	T	A	42952596	5	1	105	1	0	0	0	0	0	0	1	0	14078	1710	59	5	447	5	SERHL2	22	42952596	Splice_Site	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	1038967	42952596	8351970	429	32576										
SFRS17A	8227	broad.mit.edu	37	chrX	1719917	1719917	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccggcccacccagaggccgaCggcgctcccaaaagcgtgaa	12	17	0	2	rs149256056	byFrequency	TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:1719917C>A	uc004cqa.2	+	5	1714	c.1518C>A	c.(1516-1518)GAC>GAA	p.D506E	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	506					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAGAGGCCGACGGCGCTCCCA	0.716													1	0	0.00621372	0.006214	0.00627157	9	32										A	1719917	C	A	1719917	3	1	105	1	0	0	0	0	1	0	0	0	14173	535	19	4	1532	4	SFRS17A	23	1719917	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		1719917	153550643	430	32577										
VCX	26609	broad.mit.edu	37	chrX	7811787	7811787	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gaggaaccactgagtcaggaGagcgaggtggaagaaccact	15	8	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:7811787G>A	uc004crz.2	+	3	570	c.351G>A	c.(349-351)GAG>GAA	p.E117E		NM_013452	NP_038480	Q9H320	VCX1_HUMAN	variable charge, X chromosome	117	2.|10 X 10 AA tandem repeats of L-S-Q-E-S- [EQ]-V-E-E-P.|Glu-rich.				chromatin organization|ribosome assembly|spermatogenesis	nucleolus	chromatin binding				0		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				TGAGTCAGGAGAGCGAGGTGG	0.637													0	0	0	0.01441	0	95	48										A	7811787	G	A	7811787	2	1	105	1	0	0	0	0	0	0	0	1	17139	933	33	1		1	VCX	23	7811787	Silent	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6091870	7811787	147458773	431	32578										
KAL1	3730	broad.mit.edu	37	chrX	8538598	8538598	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	caagagacttactgctgaccAtccagctccaaaagaccttg	7	13	0	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:8538598A>G	uc004csf.2	-	7	1154	c.1004T>C	c.(1003-1005)ATG>ACG	p.M335T		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	335	Fibronectin type-III 2.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4						ACTGCTGACCATCCAGCTCCA	0.517													0	0	0	0.003163	0	14	4										G	8538598	A	G	8538598	3	3	105	1	0	0	0	0	1	0	0	0	7974	217	8	5	1070	5	KAL1	23	8538598	Missense_Mutation	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	726811	8538598	146731962	432	32579										
KLHL15	80311	broad.mit.edu	37	chrX	24006301	24006301	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gatggtccactgatcagtctCtgggttgtatacttctgtag	11	8	3	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:24006301C>T	uc004dba.3	-	4	1808	c.1552G>A	c.(1552-1554)GAG>AAG	p.E518K		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	518	Kelch 4.									ovary(1)|breast(1)	2						TGATCAGTCTCTGGGTTGTAT	0.478													0	0	0	0.01441	0	110	28										T	24006301	C	T	24006301	3	4	105	1	0	0	0	0	1	0	0	0	8371	922	32	1	266	1	KLHL15	23	24006301	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	15467703	24006301	131264259	433	32580										
EIF2S3	1968	broad.mit.edu	37	chrX	24084129	24084129	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ttttagttattagatcttttGatgtcaacaaacctggctgt	7	6	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:24084129G>C	uc004dbc.2	+	8	808	c.787G>C	c.(787-789)GAT>CAT	p.D263H		NM_001415	NP_001406	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2,	263						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			lung(1)	1						TAGATCTTTTGATGTCAACAA	0.308													0	0	0	0.004656	0	27	46										C	24084129	G	C	24084129	3	2	105	1	0	0	0	0	1	0	0	0	5011	1290	45	1	817	1	EIF2S3	23	24084129	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	77828	24084129	131186431	434	32581										
TAB3	257397	broad.mit.edu	37	chrX	30873457	30873457	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttacctgctgcatgctgagGatcaatatgtccatcacttg	8	10	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:30873457G>A	uc004dcj.2	-	6	988	c.325C>T	c.(325-327)CCT>TCT	p.P109S	TAB3_uc004dck.2_Missense_Mutation_p.P109S|TAB3_uc010ngl.2_Missense_Mutation_p.P109S	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	109					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GCATGCTGAGGATCAATATGT	0.453													0	0	0	0.008361	0	31	5										A	30873457	G	A	30873457	3	1	105	1	0	0	0	0	1	0	0	0	15494	1174	41	1	1837	1	TAB3	23	30873457	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	6789328	30873457	124397103	435	32582										
DMD	1756	broad.mit.edu	37	chrX	32382783	32382783	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgaatgatccactttgtgatGtggtccacattctggtcaaa	9	8	2	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:32382783G>T	uc004dda.1	-	36	5314	c.5070C>A	c.(5068-5070)CAC>CAA	p.H1690Q	DMD_uc004dcw.2_Missense_Mutation_p.H346Q|DMD_uc004dcx.2_Missense_Mutation_p.H349Q|DMD_uc004dcz.2_Missense_Mutation_p.H1567Q|DMD_uc004dcy.1_Missense_Mutation_p.H1686Q|DMD_uc004ddb.1_Missense_Mutation_p.H1682Q|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1690	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACTTTGTGATGTGGTCCACAT	0.363													1	0	1.35964e-18	0.01441	1.46215e-18	52	12										T	32382783	G	T	32382783	3	4	105	1	0	0	0	0	1	0	0	0	4580	1368	48	4	6311	4	DMD	23	32382783	Missense_Mutation	SNP	G	TCGA-GC-A3RC-01A-11D-A22Z-08	1509326	32382783	122887777	436	32583										
KDM6A	7403	broad.mit.edu	37	chrX	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ccagagtgcctagcgtctctCagcctggagtccgtcctgcc	11	16	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.008361	0	29	13										T	44922802	C	T	44922802	4	4	105	1	0	0	0	0	0	1	0	0	8137	827	29	1	1725	1	KDM6A	23	44922802	Nonsense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	12540019	44922802	110347758	437	32584										
MAGIX	79917	broad.mit.edu	37	chrX	49022416	49022416	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	cccaatctaatccgtagtccCgtcatggccagatcgcagcc	8	16	2	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:49022416C>T	uc010nin.1	+	6	730	c.683C>T	c.(682-684)CCG>CTG	p.P228L	MAGIX_uc010nio.1_Missense_Mutation_p.P152L|MAGIX_uc004dmt.2_Intron|MAGIX_uc004dmu.2_Missense_Mutation_p.P169L|MAGIX_uc004dmw.2_Intron	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	228											0						TCCGTAGTCCCGTCATGGCCA	0.602													0	0	0	0.007291	0	28	9										T	49022416	C	T	49022416	3	4	105	1	0	0	0	0	1	0	0	0	9193	652	23	2	745	2	MAGIX	23	49022416	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	4099614	49022416	106248144	438	32585										
FAM120C	54954	broad.mit.edu	37	chrX	54143101	54143101	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tgttcttgtcttcaactgctTtgcctagccagagcttcttg	8	11	4	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:54143101T>A	uc004dsz.3	-	10	2272	c.2189A>T	c.(2188-2190)AAA>ATA	p.K730I	FAM120C_uc011moh.1_Missense_Mutation_p.K730I	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	730										ovary(1)|central_nervous_system(1)	2						TTCAACTGCTTTGCCTAGCCA	0.527													0	0	0	0.007835	0	40	14										A	54143101	T	A	54143101	3	1	105	1	0	0	0	0	1	0	0	0	5418	1841	64	5	1129	5	FAM120C	23	54143101	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	5120685	54143101	101127459	439	32586										
ARHGEF9	23229	broad.mit.edu	37	chrX	62926191	62926191	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	acgctcagtgctcattatctCattgatgacattggcccgca	8	12	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:62926191C>T	uc004dvl.2	-	3	1167	c.328G>A	c.(328-330)GAG>AAG	p.E110K	ARHGEF9_uc004dvj.1_5'UTR|ARHGEF9_uc004dvk.1_5'UTR|ARHGEF9_uc011mos.1_Missense_Mutation_p.E89K|ARHGEF9_uc004dvm.1_Missense_Mutation_p.E89K|ARHGEF9_uc011mot.1_Missense_Mutation_p.E57K|ARHGEF9_uc004dvn.2_Missense_Mutation_p.E117K	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	110	Interaction with GPHN (By similarity).|DH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						CTCATTATCTCATTGATGACA	0.532													0	0	0	0.009096	0	4	5										T	62926191	C	T	62926191	3	4	105	1	0	0	0	0	1	0	0	0	912	835	29	1	1254	1	ARHGEF9	23	62926191	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	8783090	62926191	92344369	440	32587										
P2RY10	27334	broad.mit.edu	37	chrX	78216656	78216656	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tttgtgatcccagtgatcatCatcgcatggtgtacctggaa	10	9	2	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:78216656C>T	uc004ede.2	+	4	1008	c.639C>T	c.(637-639)ATC>ATT	p.I213I	P2RY10_uc004edf.2_Silent_p.I213I	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	213	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CAGTGATCATCATCGCATGGT	0.478													0	0	0	0.01892	0	24	35										T	78216656	C	T	78216656	2	4	105	1	0	0	0	0	0	0	0	1	11347	816	29	1		1	P2RY10	23	78216656	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	15290465	78216656	77053904	441	32588										
POF1B	79983	broad.mit.edu	37	chrX	84560911	84560911	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	attgggcctgtgcaagtctcAgaaacctacagaaggcaaaa	10	9	1	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:84560911A>G	uc004eer.2	-	13	1469	c.1323T>C	c.(1321-1323)TCT>TCC	p.S441S	POF1B_uc004ees.2_Silent_p.S441S	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	441	Potential.						actin binding				0						TGCAAGTCTCAGAAACCTACA	0.363													0	0	0	0.007835	0	42	12										G	84560911	A	G	84560911	2	3	105	1	0	0	0	0	0	0	0	1	12182	175	7	5		5	POF1B	23	84560911	Silent	SNP	A	TCGA-GC-A3RC-01A-11D-A22Z-08	6344255	84560911	70709649	442	32589										
GPRASP1	9737	broad.mit.edu	37	chrX	101911854	101911854	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	atgaggccatagtggggtccTggttctgggcaggagatgag	18	6	1	3			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:101911854T>C	uc004ejj.3	+	5	3814	c.3013T>C	c.(3013-3015)TGG>CGG	p.W1005R	GPRASP1_uc004eji.3_Missense_Mutation_p.W1005R|GPRASP1_uc010nod.2_Missense_Mutation_p.W1005R	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1005	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AGTGGGGTCCTGGTTCTGGGC	0.512													0	0	0	0.01441	0	87	20										C	101911854	T	C	101911854	3	2	105	1	0	0	0	0	1	0	0	0	6722	1580	55	5	3015	5	GPRASP1	23	101911854	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	17350943	101911854	53358706	443	32590										
CAPN6	827	broad.mit.edu	37	chrX	110489911	110489911	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	gcaggtacagagacttcagaTcacggcagtcgctggggtca	14	10	3	2			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:110489911T>C	uc004epc.1	-	13	1988	c.1820A>G	c.(1819-1821)GAT>GGT	p.D607G	CAPN6_uc011msu.1_Missense_Mutation_p.D352G	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	607	C2.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AGACTTCAGATCACGGCAGTC	0.512													0	0	0	0.01441	0	53	9										C	110489911	T	C	110489911	3	2	105	1	0	0	0	0	1	0	0	0	2630	1435	50	5	109	5	CAPN6	23	110489911	Missense_Mutation	SNP	T	TCGA-GC-A3RC-01A-11D-A22Z-08	8578057	110489911	44780649	444	32591										
CNGA2	1260	broad.mit.edu	37	chrX	150912796	150912796	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	ctagggcagctggagaccaaCatggaaaccttgtacactcg	11	11	0	1			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrX:150912796C>T	uc004fey.1	+	7	2045	c.1821C>T	c.(1819-1821)AAC>AAT	p.N607N		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	607	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TGGAGACCAACATGGAAACCT	0.572													0	0	0	0.01441	0	84	32										T	150912796	C	T	150912796	2	4	105	1	0	0	0	0	0	0	0	1	3597	477	17	2		2	CNGA2	23	150912796	Silent	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08	40422885	150912796	4357764	445	32592										
NLGN4Y	22829	broad.mit.edu	37	chrY	16835002	16835002	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.298876404494382	133	2.1243164578244e-35	3.17393557941503	3.9940484038045	2.85370104798676	5.47473427293379e-06	5.08368182486709e-05	91	tggctttttttccagatattCatgaacagaacagtaagaag	8	6	1	4			TCGA-GC-A3RC-01A-11D-A22Z-08	TCGA-GC-A3RC-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e399c9d1-d101-470f-8d30-af5ec870e95a	babe33dd-2e55-4cc6-bb64-00b6fd1106f3	g.chrY:16835002C>T	uc004ftg.2	+	3	730	c.478C>T	c.(478-480)CAT>TAT	p.H160Y	NLGN4Y_uc004fte.2_5'UTR|NLGN4Y_uc011nas.1_Missense_Mutation_p.H180Y|NLGN4Y_uc004ftf.2_5'UTR|NLGN4Y_uc004fth.2_Missense_Mutation_p.H160Y|NLGN4Y_uc004fti.3_Missense_Mutation_p.H180Y	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	160	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						TCCAGATATTCATGAACAGAA	0.413													0	0	0	0.014758	0	5	40										T	16835002	C	T	16835002	3	4	105	1	0	0	0	0	1	0	0	0	10465	826	29	1	548	1	NLGN4Y	24	16835002	Missense_Mutation	SNP	C	TCGA-GC-A3RC-01A-11D-A22Z-08		16835002	42538564	446	32593										
SCNN1D	6339	broad.mit.edu	37	chr1	1222339	1222339	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ccactcgggcagccgggtcaGagtggggttcagactggtga	17	10	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:1222339G>C	uc001adu.1	+	7	1235	c.611G>C	c.(610-612)AGA>ACA	p.R204T	SCNN1D_uc001adt.1_Missense_Mutation_p.R368T|SCNN1D_uc001adw.2_Missense_Mutation_p.R270T|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Missense_Mutation_p.R204T	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		AGCCGGGTCAGAGTGGGGTTC	0.701													0	0	0	0.175082	0	19	18										C	1222339	G	C	1222339	3	2	106	1	0	0	0	0	1	0	0	0	13929	942	33	1	827	1	SCNN1D	1	1222339	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		1222339	248028282	1	32594										
PLEKHM2	23207	broad.mit.edu	37	chr1	16053704	16053704	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	caggaggagggagaggggccGagcagcaccacggagagcag	20	9	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:16053704G>A	uc010obo.1	+	9	1364	c.1137G>A	c.(1135-1137)CCG>CCA	p.P379P		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	379					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GAGAGGGGCCGAGCAGCACCA	0.687													0	0	0	0.217242	0	6	12										A	16053704	G	A	16053704	2	1	106	1	0	0	0	0	0	0	0	1	12081	1045	37	1		1	PLEKHM2	1	16053704	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	14831365	16053704	233196917	2	32595										
ZC3H12A	80149	broad.mit.edu	37	chr1	37945897	37945897	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cctctccctcccagccatggGaacaaggaggtcttctcctg	9	16	3	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:37945897G>T	uc001cbb.3	+	3	600	c.450G>T	c.(448-450)GGG>GGT	p.G150G	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	150					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCAGCCATGGGAACAAGGAGG	0.632													1	0	2.7689e-08	0.248553	3.11215e-08	6	41										T	37945897	G	T	37945897	2	4	106	1	0	0	0	0	0	0	0	1	17558	1161	41	3		3	ZC3H12A	1	37945897	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	21892193	37945897	211304724	3	32596			1	145		3	3	110	N	G_C	7.565606e-08
ZC3H12A	80149	broad.mit.edu	37	chr1	37945923	37945923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggaggtcttctcctgccgggGcatcctgctggcagtgaact	14	12	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:37945923G>A	uc001cbb.3	+	3	626	c.476G>A	c.(475-477)GGC>GAC	p.G159D	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	159					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TCCTGCCGGGGCATCCTGCTG	0.637													0	0	0	0.047766	0	8	43										A	37945923	G	A	37945923	3	1	106	1	0	0	0	0	1	0	0	0	17558	1203	42	2	482	2	ZC3H12A	1	37945923	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	26	37945923	211304698	4	32597			1	145		3	3	110	N	G_C	7.565606e-08
ZC3H12A	80149	broad.mit.edu	37	chr1	37946006	37946006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	catcctggaggaaggagcagCctcggcccgacgtgcccatc	13	15	0	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:37946006C>T	uc001cbb.3	+	3	709	c.559C>T	c.(559-561)CCT>TCT	p.P187S	ZC3H12A_uc001cbc.1_5'UTR	NM_025079	NP_079355	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	187					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GAAGGAGCAGCCTCGGCCCGA	0.627													0	0	0	0.115264	0	3	29										T	37946006	C	T	37946006	3	4	106	1	0	0	0	0	1	0	0	0	17558	739	26	2	565	2	ZC3H12A	1	37946006	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	83	37946006	211304615	5	32598			1	145		3	3	110	N	G_C	7.565606e-08
KDM4A	9682	broad.mit.edu	37	chr1	44137208	44137208	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ccactgaagtcaaatttgaaGagcttaaaaatgtcaaacta	6	7	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:44137208G>C	uc001cjx.2	+	11	1562	c.1396G>C	c.(1396-1398)GAG>CAG	p.E466Q	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	466					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						CAAATTTGAAGAGCTTAAAAA	0.428													0	0	0	0.038147	0	5	76										C	44137208	G	C	44137208	3	2	106	1	0	0	0	0	1	0	0	0	8128	943	33	1	1434	1	KDM4A	1	44137208	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	6191202	44137208	205113413	6	32599			2	146	6191202	3	3	256	G		4.161173e-07
KDM4A	9682	broad.mit.edu	37	chr1	44137256	44137256	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aggatgaggaggaagaacaaGcagcagctgccttggatctt	14	7	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:44137256G>C	uc001cjx.2	+	11	1610	c.1444G>C	c.(1444-1446)GCA>CCA	p.A482P	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	482					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						GGAAGAACAAGCAGCAGCTGC	0.448													0	0	0	0.058154	0	7	95										C	44137256	G	C	44137256	3	2	106	1	0	0	0	0	1	0	0	0	8128	971	34	4	1482	4	KDM4A	1	44137256	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	48	44137256	205113365	7	32600			2	146	6191202	3	3	256	G		4.161173e-07
KDM4A	9682	broad.mit.edu	37	chr1	44137463	44137463	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tgcacagttatgccaaagggGatggcagggtcactgtggga	16	7	1	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:44137463G>C	uc001cjx.2	+	11	1817	c.1651G>C	c.(1651-1653)GAT>CAT	p.D551H	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	551					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TGCCAAAGGGGATGGCAGGGT	0.562													0	0	0	0.160694	0	15	114										C	44137463	G	C	44137463	3	2	106	1	0	0	0	0	1	0	0	0	8128	1174	41	1	1689	1	KDM4A	1	44137463	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	207	44137463	205113158	8	32601			2	146	6191202	3	3	256	G		4.161173e-07
RPS8	6202	broad.mit.edu	37	chr1	45242394	45242394	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cgtgtgcggggaggtaacaaGaaataccgtgccctgaggtt	15	8	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:45242394G>A	uc001cmi.2	+	3	182	c.159G>A	c.(157-159)AAG>AAA	p.K53K	SNORD38A_uc009vxi.2_5'Flank|SNORD38B_uc001cml.2_5'Flank	NM_001012	NP_001003	P62241	RS8_HUMAN	ribosomal protein S8	53					endocrine pancreas development|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					GAGGTAACAAGAAATACCGTG	0.562													0	0	0	0.058154	0	10	39										A	45242394	G	A	45242394	2	1	106	1	0	0	0	0	0	0	0	1	13661	933	33	1		1	RPS8	1	45242394	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	1104931	45242394	204008227	9	32602										
STIL	6491	broad.mit.edu	37	chr1	47725990	47725990	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tccacgttatgtgcatttttCttcactttagtgggagaatc	8	8	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:47725990C>G	uc001crc.1	-	16	3203	c.3048G>C	c.(3046-3048)AAG>AAC	p.K1016N	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.K970N|STIL_uc010omo.1_Missense_Mutation_p.K999N|STIL_uc001crd.1_Missense_Mutation_p.K1017N|STIL_uc001cre.1_Missense_Mutation_p.K1016N|STIL_uc001crf.1_Missense_Mutation_p.K629N|STIL_uc001crg.1_Missense_Mutation_p.K952N	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1016					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GTGCATTTTTCTTCACTTTAG	0.308													0	0	0	0.246493	0	41	10										G	47725990	C	G	47725990	3	3	106	1	0	0	0	0	1	0	0	0	15281	912	32	1	823	1	STIL	1	47725990	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	2483596	47725990	201524631	10	32603										
ILDR2	387597	broad.mit.edu	37	chr1	166889977	166889979	+	In_Frame_Del	DEL	CTC	CTC	-													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggctcctttttcctcttcttCtccgagttgctgtggtaggg							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:166889977_166889979delCTC	uc001gdx.1	-	9	1905_1907	c.1849_1851delGAG	c.(1849-1851)GAGdel	p.E617del		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	617	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						TCCTCTTCTTCTCCGAGTTGCTG	0.685																		2	4	---	---								-	166889979	CTC	-	166889977	7	5	106	1	0	1	0	1	0	0	0	0	7710	912	32	0	76	0	ILDR2	1	166889977	In_Frame_Del	DEL	CTC	TCGA-GC-A3RD-01A-12D-A22Z-08	119163987	166889977	82360644	11	32604										
PPFIA4	8497	broad.mit.edu	37	chr1	203024673	203024673	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gcagctgcgcaagcgtggttCcatccccacctctctgacgg	11	16	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:203024673C>A	uc001gyz.2	+	3	1018	c.425C>A	c.(424-426)TCC>TAC	p.S142Y	PPFIA4_uc009xaj.2_Missense_Mutation_p.S773Y|PPFIA4_uc010pqf.1_Missense_Mutation_p.S355Y|PPFIA4_uc001gza.2_Missense_Mutation_p.S142Y|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	142					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						AAGCGTGGTTCCATCCCCACC	0.652													1	0	0.000673444	0.069234	0.000704526	11	33										A	203024673	C	A	203024673	3	1	106	1	0	0	0	0	1	0	0	0	12312	855	30	3	435	3	PPFIA4	1	203024673	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	36134696	203024673	46225948	12	32605										
OR2M3	127062	broad.mit.edu	37	chr1	248366372	248366372	+	Frame_Shift_Del	DEL	G	G	-													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gtaaaaagcatacacatcatGgcaagggagaattcgacctt							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr1:248366372delG	uc010pzg.1	+	1	3	c.3delG	c.(1-3)ATGfs	p.M1fs		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACACATCATGGCAAGGGAGA	0.438																		41	149	---	---								-	248366372	G	-	248366372	7	5	106	1	0	1	0	1	0	0	0	0	11011	1348	47	0	5	0	OR2M3	1	248366372	Frame_Shift_Del	DEL	G	TCGA-GC-A3RD-01A-12D-A22Z-08	45341699	248366372	884249	13	32606										
TRMT61B	55006	broad.mit.edu	37	chr2	29073986	29073986	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tttaactccaattttctcttGagaatctagttgtacatctg	5	8	3	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr2:29073986G>C	uc002rmm.2	-	5	1296	c.1264C>G	c.(1264-1266)CAA>GAA	p.Q422E	TRMT61B_uc002rmn.2_Missense_Mutation_p.Q422E|TRMT61B_uc010ezk.2_Intron	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	422							tRNA (adenine-N1-)-methyltransferase activity				0						ATTTTCTCTTGAGAATCTAGT	0.363													0	0	0	0.108266	0	26	6										C	29073986	G	C	29073986	3	2	106	1	0	0	0	0	1	0	0	0	16567	1299	45	1	181	1	TRMT61B	2	29073986	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		29073986	214125387	14	32607										
PLEKHH2	130271	broad.mit.edu	37	chr2	43927132	43927132	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gagacttttggcataaagagAccagaacacaagaagctata	9	7	0	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr2:43927132A>G	uc010yny.1	+	8	1118	c.1035A>G	c.(1033-1035)AGA>AGG	p.R345R	PLEKHH2_uc002rte.3_Silent_p.R345R|PLEKHH2_uc002rtf.3_Silent_p.R344R	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	345						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCATAAAGAGACCAGAACACA	0.428													0	0	0	0.105934	0	13	47										G	43927132	A	G	43927132	2	3	106	1	0	0	0	0	0	0	0	1	12077	272	10	5		5	PLEKHH2	2	43927132	Silent	SNP	A	TCGA-GC-A3RD-01A-12D-A22Z-08	14853146	43927132	199272241	15	32608										
ATP2B2	491	broad.mit.edu	37	chr3	10417249	10417249	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggcgtgcactcaggcagccaCggcttcttgttgaccacgaa	12	13	2	1	rs113465029		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr3:10417249C>T	uc003bvt.2	-	11	1720	c.1281G>A	c.(1279-1281)CCG>CCA	p.P427P	ATP2B2_uc003bvv.2_Silent_p.P382P|ATP2B2_uc003bvw.2_Silent_p.P382P|ATP2B2_uc010hdo.2_Silent_p.P132P	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	427	Extracellular (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CAGGCAGCCACGGCTTCTTGT	0.577													0	0	0	0.132662	0	16	43										T	10417249	C	T	10417249	2	4	106	1	0	0	0	0	0	0	0	1	1140	523	19	2		2	ATP2B2	3	10417249	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		10417249	187605181	16	32609										
CNTN3	5067	broad.mit.edu	37	chr3	74350837	74350837	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	acccacggagaaaggtgtccGagcctggatagaataggata	13	8	0	2	rs144093273	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr3:74350837G>C	uc003dpm.1	-	14	1986	c.1906C>G	c.(1906-1908)CGG>GGG	p.R636G		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	636	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AAAGGTGTCCGAGCCTGGATA	0.433													0	0	0	0.080935	0	11	32										C	74350837	G	C	74350837	3	2	106	1	0	0	0	0	1	0	0	0	3642	1057	37	1	1216	1	CNTN3	3	74350837	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	63933588	74350837	123671593	17	32610										
UGT2A3	79799	broad.mit.edu	37	chr4	69811101	69811101	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ttggtatggttgaggaaattCaaaatcccaatatgttcgta	9	5	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr4:69811101C>G	uc003hef.2	-	2	818	c.787G>C	c.(787-789)GAA>CAA	p.E263Q	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	263	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TGAGGAAATTCAAAATCCCAA	0.373													0	0	0	0.069234	0	11	37										G	69811101	C	G	69811101	3	3	106	1	0	0	0	0	1	0	0	0	16952	835	29	1	816	1	UGT2A3	4	69811101	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		69811101	121343175	18	32611										
ANK2	287	broad.mit.edu	37	chr4	114280167	114280167	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gccccacaaaagaaagtaagGagcatttctttgacctttac	7	10	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr4:114280167G>T	uc003ibe.3	+	38	10493	c.10393G>T	c.(10393-10395)GAG>TAG	p.E3465*	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Nonsense_Mutation_p.E767*|ANK2_uc011cgb.1_Nonsense_Mutation_p.E3480*	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3432					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGAAAGTAAGGAGCATTTCTT	0.458													1	0	9.31168e-06	0.105934	9.97156e-06	14	37										T	114280167	G	T	114280167	4	4	106	1	0	0	0	0	0	1	0	0	621	1175	41	3	10608	3	ANK2	4	114280167	Nonsense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	44469066	114280167	76874109	19	32612										
FBXW7	55294	broad.mit.edu	37	chr4	153244232	153244232	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	atagttttacagttccatcaTctgagctggtaattacaaag	7	7	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr4:153244232T>C	uc003ims.2	-	12	2074	c.1925A>G	c.(1924-1926)GAT>GGT	p.D642G	FBXW7_uc011cii.1_Missense_Mutation_p.D642G|FBXW7_uc003imt.2_Missense_Mutation_p.D642G|FBXW7_uc011cih.1_Missense_Mutation_p.D466G|FBXW7_uc003imq.2_Missense_Mutation_p.D562G|FBXW7_uc003imr.2_Missense_Mutation_p.D524G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	642	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTTCCATCATCTGAGCTGGT	0.428			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.146539	0	16	59										C	153244232	T	C	153244232	3	2	106	1	0	0	0	0	1	0	0	0	5769	1435	50	5	202	5	FBXW7	4	153244232	Missense_Mutation	SNP	T	TCGA-GC-A3RD-01A-12D-A22Z-08	38964065	153244232	37910044	20	32613										
DDX4	54514	broad.mit.edu	37	chr5	55063741	55063741	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	actgcgaagataatccaacaCggaacagagggttttccaag	10	9	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:55063741C>T	uc003jqg.3	+	7	441	c.367C>T	c.(367-369)CGG>TGG	p.R123W	DDX4_uc010ivz.2_Intron|DDX4_uc003jqh.3_Missense_Mutation_p.R123W|DDX4_uc003jqj.2_Missense_Mutation_p.R24W	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	123	Gly-rich.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TAATCCAACACGGAACAGAGG	0.333													0	0	0	0.11911	0	11	31										T	55063741	C	T	55063741	3	4	106	1	0	0	0	0	1	0	0	0	4360	527	19	2	430	2	DDX4	5	55063741	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		55063741	125851519	21	32614										
GPR98	84059	broad.mit.edu	37	chr5	89923175	89923175	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agagtatttatttggttcctGaggaagaccacatactcata	8	7	1	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:89923175G>T	uc003kju.2	+	7	916	c.820G>T	c.(820-822)GAG>TAG	p.E274*	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	274	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTGGTTCCTGAGGAAGACCA	0.383													1	0	1.3612e-06	0.132662	1.50507e-06	13	67										T	89923175	G	T	89923175	4	4	106	1	0	0	0	0	0	1	0	0	6721	1291	45	3	846	3	GPR98	5	89923175	Nonsense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	34859434	89923175	90992085	22	32615										
GPR98	84059	broad.mit.edu	37	chr5	89923397	89923397	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	acttgaaatttcaaatagttGatgacaccataccggagatt	7	7	1	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:89923397G>A	uc003kju.2	+	7	1138	c.1042G>A	c.(1042-1044)GAT>AAT	p.D348N	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	348	Calx-beta 3.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCAAATAGTTGATGACACCAT	0.378													0	0	0	0.163468	0	32	97										A	89923397	G	A	89923397	3	1	106	1	0	0	0	0	1	0	0	0	6721	1290	45	1	1068	1	GPR98	5	89923397	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	222	89923397	90991863	23	32616										
PCDHA5	56143	broad.mit.edu	37	chr5	140202795	140202795	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	acatcttcacggtgtctgcaCgggacgcggacgcgcaggag	15	12	3	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:140202795C>T	uc003lhl.2	+	1	1435	c.1435C>T	c.(1435-1437)CGG>TGG	p.R479W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R479W|PCDHA5_uc003lhj.1_Missense_Mutation_p.R479W	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	479	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGTCTGCACGGGACGCGGA	0.662													0	0	0	0.125774	0	28	37										T	140202795	C	T	140202795	3	4	106	1	0	0	0	0	1	0	0	0	11527	527	19	2	1437	2	PCDHA5	5	140202795	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	50279398	140202795	40712465	24	32617										
PCDHA9	9752	broad.mit.edu	37	chr5	140230125	140230125	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gccaaagtcatcgtcgcgggCgtcagtgggtgccacgggcc	16	13	2	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:140230125C>T	uc003lhu.2	+	1	2769	c.2045C>T	c.(2044-2046)GCG>GTG	p.A682V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A682V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	682	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTCGCGGGCGTCAGTGGGT	0.657													0	0	0	0.175082	0	19	27										T	140230125	C	T	140230125	3	4	106	1	0	0	0	0	1	0	0	0	11531	768	27	2	2047	2	PCDHA9	5	140230125	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	27330	140230125	40685135	25	32618										
SQSTM1	8878	broad.mit.edu	37	chr5	179263552	179263552	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	actatgacatcggagcggctCtggacaccatccagtattca	9	12	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr5:179263552C>T	uc003mkw.3	+	8	1377	c.1282C>T	c.(1282-1284)CTG>TTG	p.L428L	SQSTM1_uc011dgr.1_Silent_p.L344L|SQSTM1_uc011dgs.1_Silent_p.L344L|SQSTM1_uc003mkv.3_Silent_p.L344L|SQSTM1_uc003mkx.2_Silent_p.L344L	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	428	Interaction with NTRK1 (By similarity).|UBA.				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGAGCGGCTCTGGACACCAT	0.552									Paget_Disease_of_Bone				0	0	0	0.108266	0	24	60										T	179263552	C	T	179263552	2	4	106	1	0	0	0	0	0	0	0	1	15129	912	32	1		1	SQSTM1	5	179263552	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	39033427	179263552	1651708	26	32619										
SLC17A3	10786	broad.mit.edu	37	chr6	25861865	25861865	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tccttacctgataaagcaatGctgcagagtctgcttcgttc	8	11	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:25861865G>T	uc003nfi.3	-	4	488	c.378C>A	c.(376-378)AGC>AGA	p.S126R	SLC17A3_uc003nfk.3_Missense_Mutation_p.S204R|SLC17A3_uc011djz.1_Missense_Mutation_p.S204R|SLC17A3_uc011dka.1_Missense_Mutation_p.S126R	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	126	Helical; (Potential).				glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						ATAAAGCAATGCTGCAGAGTC	0.418													1	0	1.66031e-10	0.0918	1.88168e-10	24	56										T	25861865	G	T	25861865	3	4	106	1	0	0	0	0	1	0	0	0	14418	1310	46	4	916	4	SLC17A3	6	25861865	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		25861865	145253202	27	32620										
HIST1H2BO	8348	broad.mit.edu	37	chr6	27861467	27861477	+	Frame_Shift_Del	DEL	GCGAGGCTTCC	GCGAGGCTTCC	-													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	catctttgagcgcatcgctgGcgaggcttcccgcctggcgc					rs142034002	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:27861467_27861477delGCGAGGCTTCC	uc003nkc.1	+	1	265_275	c.227_237delGCGAGGCTTCC	c.(226-237)GGCGAGGCTTCCfs	p.G76fs	HIST1H3J_uc003nka.2_5'Flank|HIST1H2AM_uc003nkb.1_5'Flank	NM_003527	NP_003518	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	76_79					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGCATCGCTGGCGAGGCTTCCCGCCTGGCGC	0.616																		28	67	---	---								-	27861477	GCGAGGCTTCC	-	27861467	7	5	106	1	0	1	0	1	0	0	0	0	7154	1203	42	0	229	0	HIST1H2BO	6	27861467	Frame_Shift_Del	DEL	GCGAGGCTTCC	TCGA-GC-A3RD-01A-12D-A22Z-08	1999602	27861467	143253600	28	32621										
KHDRBS2	202559	broad.mit.edu	37	chr6	62757854	62757854	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tgtttcttcctgtagcctctTcaaggagtttcctcttggtc	8	11	4	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:62757854T>A	uc003peg.2	-	3	512	c.265A>T	c.(265-267)AAG>TAG	p.K89*		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	89	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGTAGCCTCTTCAAGGAGTTT	0.353													0	0	0	0.204396	0	21	39										A	62757854	T	A	62757854	4	1	106	1	0	0	0	0	0	1	0	0	8147	1792	62	5	812	5	KHDRBS2	6	62757854	Nonsense_Mutation	SNP	T	TCGA-GC-A3RD-01A-12D-A22Z-08	34896387	62757854	108357213	29	32622										
B3GAT2	135152	broad.mit.edu	37	chr6	71665845	71665845	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ttggccaggcgggtcagctcCgctttctgcaccgggcggct	15	14	2	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:71665845C>T	uc003pfv.2	-	1	944	c.288G>A	c.(286-288)GCG>GCA	p.A96A	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Silent_p.A96A	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	96	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGGTCAGCTCCGCTTTCTGCA	0.697													0	0	0	0.058154	0	7	16										T	71665845	C	T	71665845	2	4	106	1	0	0	0	0	0	0	0	1	1254	639	23	2		2	B3GAT2	6	71665845	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	8907991	71665845	99449222	30	32623										
TMEM200A	114801	broad.mit.edu	37	chr6	130762085	130762085	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agtcattgacattcacacgcTaagaatcaaggagcaaaggc	9	9	3	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:130762085T>C	uc003qca.2	+	3	1389	c.518T>C	c.(517-519)CTA>CCA	p.L173P	TMEM200A_uc010kfh.2_Missense_Mutation_p.L173P|TMEM200A_uc010kfi.2_Missense_Mutation_p.L173P|TMEM200A_uc003qcb.2_Missense_Mutation_p.L173P	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	173	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ATTCACACGCTAAGAATCAAG	0.423													0	0	0	0.09319	0	10	29										C	130762085	T	C	130762085	3	2	106	1	0	0	0	0	1	0	0	0	16120	1522	53	5	520	5	TMEM200A	6	130762085	Missense_Mutation	SNP	T	TCGA-GC-A3RD-01A-12D-A22Z-08	59096240	130762085	40352982	31	32624										
IGF2R	3482	broad.mit.edu	37	chr6	160500714	160500721	+	Frame_Shift_Del	DEL	ACCAAGGG	ACCAAGGG	-													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gagtctgtctgctctcaggcAccaagggggcatcctttgga							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr6:160500714_160500721delACCAAGGG	uc003qta.2	+	38	5729_5736	c.5581_5588delACCAAGGG	c.(5581-5589)ACCAAGGGGfs	p.T1861fs		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1861_1863	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GCTCTCAGGCACCAAGGGGGCATCCTTT	0.562																		8	21	---	---								-	160500721	ACCAAGGG	-	160500714	7	5	106	1	0	1	0	1	0	0	0	0	7576	159	6	0	5731	0	IGF2R	6	160500714	Frame_Shift_Del	DEL	ACCAAGGG	TCGA-GC-A3RD-01A-12D-A22Z-08	29738629	160500714	10614353	32	32625										
C7orf26	79034	broad.mit.edu	37	chr7	6634164	6634164	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cagacgctgaagcagatattCagtgccagcccgagattctg	11	11	2	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:6634164C>T	uc003sqo.1	+	3	513	c.513C>T	c.(511-513)TTC>TTT	p.F171F	C7orf26_uc003sqp.1_Silent_p.F152F|C7orf26_uc003sqq.1_Intron	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	171										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		AGCAGATATTCAGTGCCAGCC	0.502													0	0	0	0.058154	0	9	121										T	6634164	C	T	6634164	2	4	106	1	0	0	0	0	0	0	0	1	2381	825	29	1		1	C7orf26	7	6634164	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		6634164	152504499	33	32626										
SP4	6671	broad.mit.edu	37	chr7	21469484	21469484	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gacagttccggtccaaattaGacctggtgtttcaataccac	8	11	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:21469484G>C	uc003sva.2	+	3	882	c.701G>C	c.(700-702)AGA>ACA	p.R234T	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	234					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GTCCAAATTAGACCTGGTGTT	0.443													0	0	0	0.132662	0	16	116										C	21469484	G	C	21469484	3	2	106	1	0	0	0	0	1	0	0	0	14966	942	33	1	711	1	SP4	7	21469484	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	14835320	21469484	137669179	34	32627										
ZNF92	168374	broad.mit.edu	37	chr7	64864186	64864186	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agtcctcaacccttactaaaCataaaagaattcatacggga	5	10	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:64864186C>T	uc003ttz.2	+	4	1302	c.1159C>T	c.(1159-1161)CAT>TAT	p.H387Y	ZNF92_uc003tua.2_Missense_Mutation_p.H318Y|ZNF92_uc010kzu.2_Missense_Mutation_p.H355Y|ZNF92_uc003tub.2_Missense_Mutation_p.H311Y	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	387	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CCTTACTAAACATAAAAGAAT	0.358													0	0	0	0.175082	0	19	22										T	64864186	C	T	64864186	3	4	106	1	0	0	0	0	1	0	0	0	18198	478	17	2	1173	2	ZNF92	7	64864186	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	43394702	64864186	94274477	35	32628										
SEMA3A	10371	broad.mit.edu	37	chr7	83591109	83591109	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	actacgtagcagaaggccttGatctgtcctgatgatatgat	10	8	1	5			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:83591109G>C	uc003uhz.2	-	17	2209	c.1894C>G	c.(1894-1896)CAA>GAA	p.Q632E		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	632	Ig-like C2-type.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						AGAAGGCCTTGATCTGTCCTG	0.398													0	0	0	0.146539	0	17	21										C	83591109	G	C	83591109	3	2	106	1	0	0	0	0	1	0	0	0	14024	1299	45	1	425	1	SEMA3A	7	83591109	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	18726923	83591109	75547554	36	32629										
COL1A2	1278	broad.mit.edu	37	chr7	94043017	94043017	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tttagggtgctccaggtcctGatggaaacaatggtgctcag	13	8	1	1	rs147074348		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:94043017G>A	uc003ung.1	+	27	2044	c.1573G>A	c.(1573-1575)GAT>AAT	p.D525N	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	525					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCCAGGTCCTGATGGAAACAA	0.453										HNSCC(75;0.22)			0	0	0	0.175082	0	16	25										A	94043017	G	A	94043017	3	1	106	1	0	0	0	0	1	0	0	0	3678	1290	45	1	1679	1	COL1A2	7	94043017	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	10451908	94043017	65095646	37	32630										
ACTL6B	51412	broad.mit.edu	37	chr7	100252715	100252716	+	Frame_Shift_Ins	INS	-	-	T													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gctgtaggtgtgatccaggaINStggctcggaagcactcccag							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:100252715_100252716insT	uc003uvy.2	-	4	402_403	c.295_296insA	c.(295-297)ATCfs	p.I99fs	ACTL6B_uc003uvz.2_RNA|uc003uwa.1_5'Flank	NM_016188	NP_057272	O94805	ACL6B_HUMAN	actin-like 6B	99					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex|SWI/SNF complex	ATP binding|protein binding|structural constituent of cytoskeleton			ovary(1)	1	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GTGATCCAGGATGGCTCGGAAG	0.599																		9	30	---	---								T	100252716	-	T	100252715	7	5	106	1	0	1	1	0	0	0	0	0	199	333	12	0	1028	0	ACTL6B	7	100252715	Frame_Shift_Ins	INS	-	TCGA-GC-A3RD-01A-12D-A22Z-08	6209698	100252715	58885948	38	32631										
PSMC2	5701	broad.mit.edu	37	chr7	103007921	103007921	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cagagaacaatgttggaactGatcaatcagcttgatggttt	10	6	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103007921G>C	uc003vbs.2	+	10	976	c.906G>C	c.(904-906)CTG>CTC	p.L302L	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Silent_p.L165L	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	302					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TGTTGGAACTGATCAATCAGC	0.453													0	0	0	0.132662	0	14	55										C	103007921	G	C	103007921	2	2	106	1	0	0	0	0	0	0	0	1	12686	1277	45	1		1	PSMC2	7	103007921	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	2755206	103007921	56130742	39	32632			3	147		7	7	497	G		4.257204e-20
PSMC2	5701	broad.mit.edu	37	chr7	103007988	103007988	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tgatggccactaacagacctGatactttggatccagcactg	9	11	0	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103007988G>A	uc003vbs.2	+	10	1043	c.973G>A	c.(973-975)GAT>AAT	p.D325N	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.D188N	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	325					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TAACAGACCTGATACTTTGGA	0.403													0	0	0	0.080935	0	11	48										A	103007988	G	A	103007988	3	1	106	1	0	0	0	0	1	0	0	0	12686	1290	45	1	1011	1	PSMC2	7	103007988	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	67	103007988	56130675	40	32633			3	147		7	7	497	G		4.257204e-20
PSMC2	5701	broad.mit.edu	37	chr7	103008039	103008039	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggagattggatagaaaaattGaatttagcttgcccgatcta	10	5	1	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008039G>A	uc003vbs.2	+	10	1094	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.E205K	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	342					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TAGAAAAATTGAATTTAGCTT	0.358													0	0	0	0.09319	0	13	44										A	103008039	G	A	103008039	3	1	106	1	0	0	0	0	1	0	0	0	12686	1291	45	1	1062	1	PSMC2	7	103008039	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	51	103008039	56130624	41	32634			3	147		7	7	497	G		4.257204e-20
PSMC2	5701	broad.mit.edu	37	chr7	103008218	103008218	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gagtgttgaaagagatatcaGatttgaactgttagcacgac	11	5	1	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008218G>A	uc003vbs.2	+	11	1176	c.1106G>A	c.(1105-1107)AGA>AAA	p.R369K	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.R232K	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	369					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AGAGATATCAGATTTGAACTG	0.363													0	0	0	0.189662	0	19	57										A	103008218	G	A	103008218	3	1	106	1	0	0	0	0	1	0	0	0	12686	942	33	1	1148	1	PSMC2	7	103008218	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	179	103008218	56130445	42	32635			3	147		7	7	497	G		4.257204e-20
PSMC2	5701	broad.mit.edu	37	chr7	103008346	103008346	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tttctttttgtttgaaaggtGctgagattagaagcgtctgc	11	5	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008346G>A	uc003vbs.2	+	12	1217	c.1147G>A	c.(1147-1149)GCT>ACT	p.A383T	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.A246T	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	383					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTTGAAAGGTGCTGAGATTAG	0.413													0	0	0	0.146539	0	17	65										A	103008346	G	A	103008346	3	1	106	1	0	0	0	0	1	0	0	0	12686	1319	46	2	1193	2	PSMC2	7	103008346	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	128	103008346	56130317	43	32636			3	147		7	7	497	G		4.257204e-20
PSMC2	5701	broad.mit.edu	37	chr7	103008392	103008392	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggctggtatgtttgccatcaGagcacggcgaaaaattgcta	12	8	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008392G>A	uc003vbs.2	+	12	1263	c.1193G>A	c.(1192-1194)AGA>AAA	p.R398K	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.R261K	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	398					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTTGCCATCAGAGCACGGCGA	0.423													0	0	0	0.146539	0	16	77										A	103008392	G	A	103008392	3	1	106	1	0	0	0	0	1	0	0	0	12686	942	33	1	1239	1	PSMC2	7	103008392	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	46	103008392	56130271	44	32637			3	147		7	7	497	G		4.257204e-20
PSMC2	5701	broad.mit.edu	37	chr7	103008417	103008417	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cggcgaaaaattgctaccgaGaaggatttcttggaagctgt	12	7	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr7:103008417G>A	uc003vbs.2	+	12	1288	c.1218G>A	c.(1216-1218)GAG>GAA	p.E406E	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Silent_p.E269E	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	406					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TTGCTACCGAGAAGGATTTCT	0.423													0	0	0	0.146539	0	17	66										A	103008417	G	A	103008417	2	1	106	1	0	0	0	0	0	0	0	1	12686	933	33	1		1	PSMC2	7	103008417	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	25	103008417	56130246	45	32638			3	147		7	7	497	G		4.257204e-20
CTHRC1	115908	broad.mit.edu	37	chr8	104388121	104388121	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gaaagctttgaggagtcctgGacacccaactacaagcagtg	11	10	0	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr8:104388121G>A	uc003ylk.2	+	2	405	c.306G>A	c.(304-306)TGG>TGA	p.W102*	CTHRC1_uc011lhq.1_Nonsense_Mutation_p.W102*	NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	102						collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			AGGAGTCCTGGACACCCAACT	0.453													0	0	0	0.058154	0	10	64										A	104388121	G	A	104388121	4	1	106	1	0	0	0	0	0	1	0	0	4010	1183	41	1	312	1	CTHRC1	8	104388121	Nonsense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		104388121	41975901	46	32639										
ZFP37	7539	broad.mit.edu	37	chr9	115806366	115806366	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	caaaatttttccacatgactCaaatttaagaagccttttct	3	9	2	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr9:115806366C>G	uc004bgm.1	-	4	560	c.532G>C	c.(532-534)GAG>CAG	p.E178Q	ZFP37_uc011lwz.1_Missense_Mutation_p.E193Q|ZFP37_uc011lxa.1_Missense_Mutation_p.E179Q	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	178						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCACATGACTCAAATTTAAGA	0.333													0	0	0	0.047766	0	9	38										G	115806366	C	G	115806366	3	3	106	1	0	0	0	0	1	0	0	0	17645	835	29	1	1364	1	ZFP37	9	115806366	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		115806366	25407065	47	32640										
PAPPA	5069	broad.mit.edu	37	chr9	118982346	118982346	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ctcgccccccaagttctgggCcacacaacggactctgtgac	9	17	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr9:118982346C>A	uc004bjn.2	+	5	2430	c.2049C>A	c.(2047-2049)GGC>GGA	p.G683G	PAPPA_uc011lxp.1_Silent_p.G378G|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	683					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGTTCTGGGCCACACAACGG	0.562													1	0	2.6416e-12	0.235728	3.07058e-12	37	57										A	118982346	C	A	118982346	2	1	106	1	0	0	0	0	0	0	0	1	11432	726	26	4		4	PAPPA	9	118982346	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	3175980	118982346	22231085	48	32641										
GPR21	2844	broad.mit.edu	37	chr9	125797575	125797575	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gggagactggggaagtgcagGcctgtcctgataagcgctat	16	8	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr9:125797575G>A	uc011lzk.1	+	1	730	c.730G>A	c.(730-732)GCC>ACC	p.A244T	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	244	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GGAAGTGCAGGCCTGTCCTGA	0.488													0	0	0	0.219247	0	20	61										A	125797575	G	A	125797575	3	1	106	1	0	0	0	0	1	0	0	0	6681	1203	42	2	732	2	GPR21	9	125797575	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	6815229	125797575	15415856	49	32642										
THNSL1	79896	broad.mit.edu	37	chr10	25314303	25314303	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agaacaaaacagcaagagaaGatggagtaccaggtctgtgc	12	7	1	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:25314303G>C	uc001isi.3	+	3	2480	c.2151G>C	c.(2149-2151)AAG>AAC	p.K717N	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	717					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	AGCAAGAGAAGATGGAGTACC	0.388													0	0	0	0.058154	0	9	40										C	25314303	G	C	25314303	3	2	106	1	0	0	0	0	1	0	0	0	15859	933	33	1	2153	1	THNSL1	10	25314303	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		25314303	110220444	50	32643										
ZNF365	22891	broad.mit.edu	37	chr10	64415128	64415128	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ctggggttcttccacaaagtCaacacatctaaagaagccac	7	12	3	1	rs79964532		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:64415128C>T	uc001jmd.1	+	4	462	c.128C>T	c.(127-129)TCA>TTA	p.S43L	ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	43										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					TCCACAAAGTCAACACATCTA	0.408													0	0	0	0.038147	0	7	16										T	64415128	C	T	64415128	3	4	106	1	0	0	0	0	1	0	0	0	17866	840	29	1	1616	1	ZNF365	10	64415128	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	39100825	64415128	71119619	51	32644										
PSAP	5660	broad.mit.edu	37	chr10	73587834	73587834	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	acatgttccaccaaggcctgGacaaaggtggagttggtccg	13	10	0	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:73587834G>A	uc001jsm.2	-	6	761	c.657C>T	c.(655-657)GTC>GTT	p.V219V		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	219	Saposin B-type 2.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CCAAGGCCTGGACAAAGGTGG	0.552													0	0	0	0.184627	0	5	50										A	73587834	G	A	73587834	2	1	106	1	0	0	0	0	0	0	0	1	12643	1161	41	1		1	PSAP	10	73587834	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	9172706	73587834	61946913	52	32645										
TLL2	7093	broad.mit.edu	37	chr10	98136543	98136543	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agttggggctcgccagggtcCcctccacactgctgatcttg	12	14	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr10:98136543C>T	uc001kml.1	-	18	2580	c.2354G>A	c.(2353-2355)GGG>GAG	p.G785E		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	785	CUB 4.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CGCCAGGGTCCCCTCCACACT	0.572													0	0	0	0.203993	0	35	15										T	98136543	C	T	98136543	3	4	106	1	0	0	0	0	1	0	0	0	15943	623	22	2	709	2	TLL2	10	98136543	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	24548709	98136543	37398204	53	32646										
OR51S1	119692	broad.mit.edu	37	chr11	4869946	4869946	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cagcaggaatggcaggggcaGatggagacccaggcatcgaa	16	9	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:4869946G>A	uc010qyo.1	-	1	493	c.493C>T	c.(493-495)CTG>TTG	p.L165L		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	165	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCAGGGGCAGATGGAGACCC	0.557													0	0	0	0.09319	0	12	44										A	4869946	G	A	4869946	2	1	106	1	0	0	0	0	0	0	0	1	11105	933	33	1		1	OR51S1	11	4869946	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		4869946	130136570	54	32647										
MMP26	56547	broad.mit.edu	37	chr11	5009489	5009489	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	atcttcttgccctggtgtttCgccgttccagtgccccctgc	9	16	2	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:5009489C>T	uc001lzv.2	+	1	66	c.48C>T	c.(46-48)TTC>TTT	p.F16F		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	16					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTGGTGTTTCGCCGTTCCAG	0.502											OREG0003716	type=REGULATORY REGION|Gene=MMP26|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.26419	0	21	31										T	5009489	C	T	5009489	2	4	106	1	0	0	0	0	0	0	0	1	9663	883	31	1		1	MMP26	11	5009489	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	139543	5009489	129997027	55	32648										
ABCC8	6833	broad.mit.edu	37	chr11	17436131	17436131	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ttagcagccatggtttctgcGaagcataggccacggggcct	13	11	1	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:17436131G>A	uc001mnc.2	-	19	2444	c.2318C>T	c.(2317-2319)TCG>TTG	p.S773L		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	773	ABC transporter 1.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTTTCTGCGAAGCATAGGC	0.547													0	0	0	0.099896	0	26	37										A	17436131	G	A	17436131	3	1	106	1	0	0	0	0	1	0	0	0	58	1059	37	1	2511	1	ABCC8	11	17436131	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	12426642	17436131	117570385	56	32649										
DTX4	23220	broad.mit.edu	37	chr11	58962721	58962721	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aacctgcaagaccatttatgGggtgaagacaggcacccaac	10	11	0	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:58962721G>C	uc001nns.2	+	7	1672	c.1415G>C	c.(1414-1416)GGG>GCG	p.G472A	DTX4_uc001nnr.2_Missense_Mutation_p.G366A	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	472					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				ACCATTTATGGGGTGAAGACA	0.532													0	0	0	0.105934	0	13	35										C	58962721	G	C	58962721	3	2	106	1	0	0	0	0	1	0	0	0	4797	1232	43	4	1441	4	DTX4	11	58962721	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	41526590	58962721	76043795	57	32650										
ANKRD13D	338692	broad.mit.edu	37	chr11	67068497	67068497	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tggctgagtgaagagcacccGctctccctgggtgaccaggt	14	12	1	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:67068497G>A	uc001okc.1	+	12	1360	c.849G>A	c.(847-849)CCG>CCA	p.P283P	ANKRD13D_uc001okd.1_Silent_p.P370P|ANKRD13D_uc001oke.1_Silent_p.P283P|ANKRD13D_uc001okg.1_Silent_p.P66P|ANKRD13D_uc001okh.1_Silent_p.P66P|ANKRD13D_uc001oki.1_Silent_p.P20P|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	283										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AAGAGCACCCGCTCTCCCTGG	0.612													0	0	0	0.11911	0	15	46										A	67068497	G	A	67068497	2	1	106	1	0	0	0	0	0	0	0	1	644	1074	38	2		2	ANKRD13D	11	67068497	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	8105776	67068497	67938019	58	32651										
FAT3	120114	broad.mit.edu	37	chr11	92088561	92088561	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ttggaaggttcagtatagacGacgagagtggtaagtgtaat	14	3	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:92088561G>A	uc001pdj.3	+	1	3300	c.3283G>A	c.(3283-3285)GAC>AAC	p.D1095N		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1095	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGTATAGACGACGAGAGTGG	0.453										TCGA Ovarian(4;0.039)			0	0	0	0.184627	0	5	24										A	92088561	G	A	92088561	3	1	106	1	0	0	0	0	1	0	0	0	5691	1058	37	1	3285	1	FAT3	11	92088561	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	25020064	92088561	42917955	59	32652										
FOLR4	390243	broad.mit.edu	37	chr11	94039818	94039818	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tcggaagcacttcatccaggCtatctgcttctatgagtgct	9	11	3	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:94039818C>T	uc010rud.1	+	2	278	c.278C>T	c.(277-279)GCT>GTT	p.A93V		NM_001080486	NP_001073955	A6ND01	FOLR4_HUMAN	folate receptor 4 (delta) homolog	93						extracellular region	folic acid binding|receptor activity			ovary(1)	1						TTCATCCAGGCTATCTGCTTC	0.567													0	0	0	0.160694	0	18	43										T	94039818	C	T	94039818	3	4	106	1	0	0	0	0	1	0	0	0	5984	797	28	2	284	2	FOLR4	11	94039818	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	1951257	94039818	40966698	60	32653										
GRIA4	2893	broad.mit.edu	37	chr11	105795422	105795422	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ccagcgaccagcctcccaatGagtttggcatctttaacagc	8	14	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:105795422G>T	uc001pix.2	+	12	2220	c.1774G>T	c.(1774-1776)GAG>TAG	p.E592*	GRIA4_uc001piw.2_Nonsense_Mutation_p.E592*	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	592	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GCCTCCCAATGAGTTTGGCAT	0.468													1	0	1.12685e-05	0.047766	1.19728e-05	9	15										T	105795422	G	T	105795422	4	4	106	1	0	0	0	0	0	1	0	0	6770	1291	45	3	1853	3	GRIA4	11	105795422	Nonsense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	11755604	105795422	29211094	61	32654										
ZC3H12C	85463	broad.mit.edu	37	chr11	110035202	110035202	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	actgcaaacgaaggaggactGgtgaaaagcaacagtgttcc	12	8	0	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr11:110035202G>A	uc009yxw.2	+	6	1443	c.1392G>A	c.(1390-1392)CTG>CTA	p.L464L	ZC3H12C_uc010rwc.1_Silent_p.L465L|ZC3H12C_uc010rwd.1_Silent_p.L465L|ZC3H12C_uc001pkr.3_Silent_p.L433L	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	464							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		AAGGAGGACTGGTGAAAAGCA	0.512													0	0	0	0.115264	0	3	23										A	110035202	G	A	110035202	2	1	106	1	0	0	0	0	0	0	0	1	17560	1335	47	2		2	ZC3H12C	11	110035202	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	4239780	110035202	24971314	62	32655										
KCNA6	3742	broad.mit.edu	37	chr12	4920041	4920041	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gtctggttcacttttgagctCctggtgcgcttctccgcctg	11	13	3	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:4920041C>T	uc001qng.2	+	1	1700	c.834C>T	c.(832-834)CTC>CTT	p.L278L		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	278	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CTTTTGAGCTCCTGGTGCGCT	0.557										HNSCC(72;0.22)			0	0	0	0.0918	0	25	71										T	4920041	C	T	4920041	2	4	106	1	0	0	0	0	0	0	0	1	8007	842	30	1		1	KCNA6	12	4920041	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		4920041	128931854	63	32656										
MLL2	8085	broad.mit.edu	37	chr12	49434618	49434618	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggccacccaggtgggtgcctGaggagggtgagtcaacaaag	17	9	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:49434618G>A	uc001rta.3	-	31	6935	c.6935C>T	c.(6934-6936)TCA>TTA	p.S2312L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2312	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GTGGGTGCCTGAGGAGGGTGA	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.038147	0	8	22										A	49434618	G	A	49434618	3	1	106	1	0	0	0	0	1	0	0	0	9621	1294	45	1	9774	1	MLL2	12	49434618	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	44514577	49434618	84417277	64	32657										
CPSF6	11052	broad.mit.edu	37	chr12	69652453	69652453	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cacctcctggtcaggttctgCctcctcctctagctgggcct	9	17	3	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:69652453C>T	uc001sut.3	+	6	888	c.778C>T	c.(778-780)CCT>TCT	p.P260S	CPSF6_uc001suu.3_Missense_Mutation_p.P297S|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	260	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TCAGGTTCTGCCTCCTCCTCT	0.577													0	0	0	0.099896	0	27	842										T	69652453	C	T	69652453	3	4	106	1	0	0	0	0	1	0	0	0	3829	739	26	2	800	2	CPSF6	12	69652453	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	20217835	69652453	64199442	65	32658										
UBE2N	7334	broad.mit.edu	37	chr12	93803827	93803827	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gtatcaatttaaatattattCatggcatatagcctagtcca	5	7	2	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:93803827C>T	uc001tcp.2	-	4	813	c.447G>A	c.(445-447)ATG>ATA	p.M149I		NM_003348	NP_003339	P61088	UBE2N_HUMAN	ubiquitin-conjugating enzyme E2N	149					DNA double-strand break processing|double-strand break repair via homologous recombination|histone ubiquitination|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of DNA repair|positive regulation of histone modification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity|postreplication repair|protein K63-linked ubiquitination|proteolysis|regulation of histone ubiquitination|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-MMS2 complex|UBC13-UEV1A complex|ubiquitin ligase complex	ATP binding|ubiquitin binding|ubiquitin-protein ligase activity				0						AAATATTATTCATGGCATATA	0.348								Direct_reversal_of_damage|Rad6_pathway					0	0	0	0.038147	0	8	14										T	93803827	C	T	93803827	3	4	106	1	0	0	0	0	1	0	0	0	16863	826	29	1	15	1	UBE2N	12	93803827	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	24151374	93803827	40048068	66	32659										
FBXO21	23014	broad.mit.edu	37	chr12	117628253	117628253	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	atcgcgctgtcgactgctgcCgccgccatcttgtccgcgta	11	16	1	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr12:117628253C>T	uc001twk.2	-	1	48	c.9G>A	c.(7-9)GCG>GCA	p.A3A	FBXO21_uc001twj.2_Silent_p.A3A|FBXO21_uc009zwq.2_Silent_p.A3A	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	3					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		cgactgctgccgccgccATCT	0.478													0	0	0	0.115264	0	2	2										T	117628253	C	T	117628253	2	4	106	1	0	0	0	0	0	0	0	1	5733	639	23	2		2	FBXO21	12	117628253	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	23824426	117628253	16223642	67	32660										
SPATA13	221178	broad.mit.edu	37	chr13	24868942	24868942	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggcctgtctgatcaacgagcGcaagcgcaagctggagagca	14	11	2	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:24868942G>A	uc001upg.1	+	9	1678	c.1271G>A	c.(1270-1272)CGC>CAC	p.R424H	SPATA13_uc001upd.1_Missense_Mutation_p.R1049H|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Missense_Mutation_p.R370H|SPATA13_uc010tcz.1_Missense_Mutation_p.R308H|SPATA13_uc010tda.1_Missense_Mutation_p.R368H|SPATA13_uc001uph.2_Missense_Mutation_p.R346H|SPATA13_uc010tdb.1_Missense_Mutation_p.R284H|SPATA13_uc009zzz.1_Intron|SPATA13_uc001upi.1_5'Flank	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	424	DH.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		ATCAACGAGCGCAAGCGCAAG	0.498													0	0	0	0.150653	0	4	35										A	24868942	G	A	24868942	3	1	106	1	0	0	0	0	1	0	0	0	14999	1087	38	2	3180	2	SPATA13	13	24868942	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		24868942	90300936	68	32661										
RBM26	64062	broad.mit.edu	37	chr13	79928636	79928636	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aatagtacttgaaggtactgGacccagccgctctttgactg	10	10	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:79928636G>C	uc001vkz.2	-	13	1944	c.1930C>G	c.(1930-1932)CCA>GCA	p.P644A	RBM26_uc001vky.2_Missense_Mutation_p.P639A|RBM26_uc001vla.2_Missense_Mutation_p.P642A|RBM26_uc010tia.1_Missense_Mutation_p.P23A|RBM26_uc001vkx.2_Missense_Mutation_p.P354A	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	642					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GAAGGTACTGGACCCAGCCGC	0.463													0	0	0	0.173368	0	36	9										C	79928636	G	C	79928636	3	2	106	1	0	0	0	0	1	0	0	0	13126	1174	41	1	1063	1	RBM26	13	79928636	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	55059694	79928636	35241242	69	32662										
DCUN1D2	55208	broad.mit.edu	37	chr13	114138370	114138370	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tctgagacgatttaagcttaTgctttgggatgcaaaagaag	11	5	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr13:114138370T>C	uc001vtr.1	-	2	44	c.5A>G	c.(4-6)CAT>CGT	p.H2R	DCUN1D2_uc001vts.1_RNA|DCUN1D2_uc010agw.1_Intron	NM_001014283	NP_001014305	Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain	2											0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			TTTAAGCTTATGCTTTGGGAT	0.493													0	0	0	0.139131	0	57	13										C	114138370	T	C	114138370	3	2	106	1	0	0	0	0	1	0	0	0	4314	1478	51	5	798	5	DCUN1D2	13	114138370	Missense_Mutation	SNP	T	TCGA-GC-A3RD-01A-12D-A22Z-08	34209734	114138370	1031508	70	32663										
FBN1	2200	broad.mit.edu	37	chr15	48905226	48905226	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cggacaatacactgatttccGccaggtaaggttttccatcc	8	12	0	1	rs141651917	byFrequency	TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:48905226G>T	uc001zwx.1	-	3	556	c.228C>A	c.(226-228)GGC>GGA	p.G76G		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	76					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACTGATTTCCGCCAGGTAAGG	0.393													1	0	0.00316338	0.132662	0.00321059	14	54										T	48905226	G	T	48905226	2	4	106	1	0	0	0	0	0	0	0	1	5702	1074	38	4		4	FBN1	15	48905226	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		48905226	53626166	71	32664										
ATP8B4	79895	broad.mit.edu	37	chr15	50158634	50158634	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	taaatggcaatgctcccccaGatgaagacgtgattaatgaa	9	8	0	5			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:50158634G>A	uc001zxu.2	-	26	3217	c.3075C>T	c.(3073-3075)ATC>ATT	p.I1025I	ATP8B4_uc010ber.2_Silent_p.I898I|ATP8B4_uc010ufd.1_Silent_p.I835I|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Silent_p.I28I	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1025	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGCTCCCCCAGATGAAGACGT	0.388													0	0	0	0.204396	0	19	44										A	50158634	G	A	50158634	2	1	106	1	0	0	0	0	0	0	0	1	1197	932	33	1		1	ATP8B4	15	50158634	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	1253408	50158634	52372758	72	32665										
ATP8B4	79895	broad.mit.edu	37	chr15	50189507	50189507	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	acctgggctgagaaaccacaGaagaaaccaaaccagaaatg	9	10	0	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:50189507G>A	uc001zxu.2	-	23	2821	c.2679C>T	c.(2677-2679)TTC>TTT	p.F893F	ATP8B4_uc010ber.2_Silent_p.F766F|ATP8B4_uc010ufd.1_Silent_p.F703F|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Silent_p.F191F	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	893	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AGAAACCACAGAAGAAACCAA	0.299													0	0	0	0.083992	0	26	81										A	50189507	G	A	50189507	2	1	106	1	0	0	0	0	0	0	0	1	1197	933	33	1		1	ATP8B4	15	50189507	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	30873	50189507	52341885	73	32666										
KIAA1370	56204	broad.mit.edu	37	chr15	52903959	52903959	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tgtgacctcagacctagttcGtctggcttggcggcacttag	12	11	2	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:52903959G>A	uc002acg.3	-	4	370	c.217C>T	c.(217-219)CGA>TGA	p.R73*	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Translation_Start_Site|KIAA1370_uc010ugf.1_Nonsense_Mutation_p.R80*	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	73											0				all cancers(107;0.0803)		GACCTAGTTCGTCTGGCTTGG	0.398													0	0	0	0.11911	0	13	43										A	52903959	G	A	52903959	4	1	106	1	0	0	0	0	0	1	0	0	8226	1153	40	2	3053	2	KIAA1370	15	52903959	Nonsense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	2714452	52903959	49627433	74	32667										
ZNF280D	54816	broad.mit.edu	37	chr15	56961028	56961028	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tattttaactcacttttgttCcaggaggcaatccttctagt	6	9	2	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:56961028C>G	uc002adu.2	-	14	1755	c.1538G>C	c.(1537-1539)GGA>GCA	p.G513A	ZNF280D_uc002adv.2_Missense_Mutation_p.G500A|ZNF280D_uc010bfq.2_Missense_Mutation_p.G513A|ZNF280D_uc002adw.1_Missense_Mutation_p.G541A|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	513					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CACTTTTGTTCCAGGAGGCAA	0.318													0	0	0	0.038147	0	7	26										G	56961028	C	G	56961028	3	3	106	1	0	0	0	0	1	0	0	0	17814	855	30	1	1437	1	ZNF280D	15	56961028	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	4057069	56961028	45570364	75	32668										
SCAPER	49855	broad.mit.edu	37	chr15	76994184	76994184	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ttctccctttaacatggctaAaaagatatacctctgaagag	6	9	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:76994184A>T	uc002bby.2	-	19	2482	c.2423T>A	c.(2422-2424)TTT>TAT	p.F808Y	SCAPER_uc010bkr.2_Missense_Mutation_p.F116Y|SCAPER_uc002bbx.2_Missense_Mutation_p.F562Y|SCAPER_uc002bbz.1_Missense_Mutation_p.F679Y|SCAPER_uc002bca.1_Missense_Mutation_p.F673Y	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	807	C2H2-type.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AACATGGCTAAAAAGATATAC	0.358													0	0	0	0.11911	0	13	19										T	76994184	A	T	76994184	3	4	106	1	0	0	0	0	1	0	0	0	13878	14	1	5	1831	5	SCAPER	15	76994184	Missense_Mutation	SNP	A	TCGA-GC-A3RD-01A-12D-A22Z-08	20033156	76994184	25537208	76	32669										
HOMER2	9455	broad.mit.edu	37	chr15	83532988	83532988	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gctatcttggcagcttctttCacctcctggaatttctctgc	7	13	4	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:83532988C>A	uc002bjg.2	-	4	504	c.318G>T	c.(316-318)GTG>GTT	p.V106V	HOMER2_uc002bjh.2_Silent_p.V106V|HOMER2_uc002bjj.2_Silent_p.V106V|HOMER2_uc002bji.2_Silent_p.V106V	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	106	Potential.|WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						CAGCTTCTTTCACCTCCTGGA	0.388													1	0	2.0095e-06	0.248553	2.20397e-06	6	23										A	83532988	C	A	83532988	2	1	106	1	0	0	0	0	0	0	0	1	7279	813	29	3		3	HOMER2	15	83532988	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	6538804	83532988	18998404	77	32670										
BNC1	646	broad.mit.edu	37	chr15	83933066	83933066	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	atgggtgctgtcttctttttTagtaatagcatccggacagt	10	7	2	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr15:83933066T>C	uc002bjt.1	-	4	1025	c.937A>G	c.(937-939)AAA>GAA	p.K313E	BNC1_uc010uos.1_Missense_Mutation_p.K301E	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	313					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						TCTTCTTTTTTAGTAATAGCA	0.438													0	0	0	0.09319	0	12	47										C	83933066	T	C	83933066	3	2	106	1	0	0	0	0	1	0	0	0	1474	1763	61	5	2055	5	BNC1	15	83933066	Missense_Mutation	SNP	T	TCGA-GC-A3RD-01A-12D-A22Z-08	400078	83933066	18598326	78	32671										
CREBBP	1387	broad.mit.edu	37	chr16	3828084	3828085	+	Frame_Shift_Ins	INS	-	-	C													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gctggtaaggctggctggttINSccccaagatgccttgtttat							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr16:3828084_3828085insC	uc002cvv.2	-	10	2244_2245	c.2040_2041insG	c.(2038-2043)GGGAACfs	p.G680fs	CREBBP_uc002cvw.2_Frame_Shift_Ins_p.G642fs	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	680_681					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCTGGCTGGTTCCCCAAGATGC	0.46			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome									39	108	---	---								C	3828085	-	C	3828084	7	5	106	1	0	1	1	0	0	0	0	0	3861	1783	62	0	5375	0	CREBBP	16	3828084	Frame_Shift_Ins	INS	-	TCGA-GC-A3RD-01A-12D-A22Z-08		3828084	86526669	79	32672										
POLR3E	55718	broad.mit.edu	37	chr16	22320249	22320249	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gtgcttggtgcctccaggtaGagcttgagatggccatcgac	14	10	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr16:22320249G>A	uc002dkk.2	+	5	325	c.169G>A	c.(169-171)GAG>AAG	p.E57K	POLR3E_uc002dkj.1_Missense_Mutation_p.E57K|POLR3E_uc002dkm.2_Missense_Mutation_p.E21K|POLR3E_uc010vbr.1_Missense_Mutation_p.E57K|POLR3E_uc002dkl.2_Missense_Mutation_p.E57K|POLR3E_uc010vbs.1_Missense_Mutation_p.E21K|POLR3E_uc010vbt.1_Intron	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	57					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		CCTCCAGGTAGAGCTTGAGAT	0.627													0	0	0	0.09319	0	13	33										A	22320249	G	A	22320249	3	1	106	1	0	0	0	0	1	0	0	0	12232	943	33	1	183	1	POLR3E	16	22320249	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	18492165	22320249	68034504	80	32673										
IRX5	10265	broad.mit.edu	37	chr16	54966775	54966775	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aacgacgaggacgagccccaGaagcccgaggacaagggcga	15	12	0	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr16:54966775G>A	uc002ehv.2	+	2	615	c.615G>A	c.(613-615)CAG>CAA	p.Q205Q	IRX5_uc010cca.1_Silent_p.Q257Q|IRX5_uc002ehw.2_Silent_p.Q139Q	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	205					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						ACGAGCCCCAGAAGCCCGAGG	0.592													0	0	0	0.11911	0	14	41										A	54966775	G	A	54966775	2	1	106	1	0	0	0	0	0	0	0	1	7847	933	33	1		1	IRX5	16	54966775	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	32646526	54966775	35387978	81	32674										
ZZEF1	23140	broad.mit.edu	37	chr17	3974013	3974013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tctcatataaatctggagtgCgatacaccagagcagcaaag	9	9	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:3974013C>T	uc002fxe.2	-	26	4104	c.4040G>A	c.(4039-4041)CGC>CAC	p.R1347H	ZZEF1_uc002fxj.1_5'UTR	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1347							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATCTGGAGTGCGATACACCAG	0.393													0	0	0	0.160694	0	18	42										T	3974013	C	T	3974013	3	4	106	1	0	0	0	0	1	0	0	0	18252	768	27	2	4965	2	ZZEF1	17	3974013	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		3974013	77221197	82	32675										
CNTROB	116840	broad.mit.edu	37	chr17	7838454	7838454	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gcattggattcagagcatacCcgccgcaaggtaagatgcaa	11	10	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:7838454C>A	uc002gjq.2	+	5	1504	c.585C>A	c.(583-585)ACC>ACA	p.T195T	CNTROB_uc002gjp.2_Silent_p.T195T|CNTROB_uc002gjr.2_Silent_p.T97T|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	195					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				CAGAGCATACCCGCCGCAAGG	0.502													1	0	0.004672	0.115264	0.00470661	3	19										A	7838454	C	A	7838454	2	1	106	1	0	0	0	0	0	0	0	1	3651	610	22	4		4	CNTROB	17	7838454	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	3864441	7838454	73356756	83	32676										
EFCAB5	374786	broad.mit.edu	37	chr17	28296048	28296049	+	Frame_Shift_Ins	INS	-	-	A													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aaatctgaagaaggaactagINSaaaaaaaggctgaaaaaaaa							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:28296048_28296049insA	uc002het.2	+	4	622_623	c.430_431insA	c.(430-432)GAAfs	p.E144fs	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Frame_Shift_Ins_p.E88fs|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Frame_Shift_Ins_p.E23fs|EFCAB5_uc010csf.2_Frame_Shift_Ins_p.E23fs	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	144							calcium ion binding			ovary(1)|skin(1)	2						GAAGGAACTAGAAAAAAAGGCT	0.366																		6	8	---	---								A	28296049	-	A	28296048	7	5	106	1	0	1	1	0	0	0	0	0	4938	943	33	0	444	0	EFCAB5	17	28296048	Frame_Shift_Ins	INS	-	TCGA-GC-A3RD-01A-12D-A22Z-08	20457594	28296048	52899162	84	32677										
ITGA3	3675	broad.mit.edu	37	chr17	48149456	48149456	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cgggaacctccttccctgctCacccctcactccttcttcat	4	20	4	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:48149456C>T	uc010dbl.2	+	7	1530	c.1066C>T	c.(1066-1068)CAC>TAC	p.H356Y	ITGA3_uc010dbm.2_Missense_Mutation_p.H356Y	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	356	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						CTTCCCTGCTCACCCCTCACT	0.562													0	0	0	0.189662	0	19	43										T	48149456	C	T	48149456	3	4	106	1	0	0	0	0	1	0	0	0	7877	826	29	1	1092	1	ITGA3	17	48149456	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	19853408	48149456	33045754	85	32678										
WFIKKN2	124857	broad.mit.edu	37	chr17	48917902	48917902	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ccagtcctttgtctatggtgGctgcgagggcaatggcaaca	13	10	1	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:48917902G>A	uc002isv.3	+	2	1947	c.1253G>A	c.(1252-1254)GGC>GAC	p.G418D	WFIKKN2_uc010dbu.2_Missense_Mutation_p.G325D	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	418	BPTI/Kunitz inhibitor 2.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTCTATGGTGGCTGCGAGGGC	0.667													0	0	0	0.175082	0	18	35										A	48917902	G	A	48917902	3	1	106	1	0	0	0	0	1	0	0	0	17356	1203	42	2	1259	2	WFIKKN2	17	48917902	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	768446	48917902	32277308	86	32679										
CA10	56934	broad.mit.edu	37	chr17	49710985	49710985	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aagatctgagatggctggttCtggctgagcaggcgcaagga	16	7	2	3	rs149523462		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr17:49710985C>A	uc002itw.3	-	8	1802	c.816G>T	c.(814-816)CAG>CAT	p.Q272H	CA10_uc002itu.3_Missense_Mutation_p.Q201H|CA10_uc002itv.3_Missense_Mutation_p.Q278H|CA10_uc002itx.3_Missense_Mutation_p.Q272H|CA10_uc002ity.3_Missense_Mutation_p.Q272H|CA10_uc002itz.2_Missense_Mutation_p.Q272H	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	272					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			ATGGCTGGTTCTGGCTGAGCA	0.498													1	0	2.23348e-06	0.146539	2.43003e-06	15	46										A	49710985	C	A	49710985	3	1	106	1	0	0	0	0	1	0	0	0	2511	912	32	3	178	3	CA10	17	49710985	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	793083	49710985	31484225	87	32680										
TRIP10	9322	broad.mit.edu	37	chr19	6750343	6750343	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	aagtcgagtccttagcaaccGgggagacagcctgagccggc	14	12	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:6750343G>T	uc002mfs.2	+	13	1502	c.1436G>T	c.(1435-1437)CGG>CTG	p.R479L	TRIP10_uc010dux.1_Missense_Mutation_p.R423L|TRIP10_uc002mfr.2_Missense_Mutation_p.R423L|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.R242L	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	479	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.|Required for interaction with FASLG and localization to lysosomes.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						CTTAGCAACCGGGGAGACAGC	0.667													1	0	0.00185496	0.105934	0.00192576	13	47										T	6750343	G	T	6750343	3	4	106	1	0	0	0	0	1	0	0	0	16551	1116	39	4	1314	4	TRIP10	19	6750343	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		6750343	52378640	88	32681										
APLP1	333	broad.mit.edu	37	chr19	36369487	36369487	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agatcagacttgggggtaggGtccacagaacaagatgctgc	14	8	1	4			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:36369487G>A	uc002oce.2	+	14	1716	c.1578G>A	c.(1576-1578)GGG>GGA	p.G526G	APLP1_uc010xsz.1_Silent_p.G487G|APLP1_uc002ocf.2_Silent_p.G527G|APLP1_uc002ocg.2_Silent_p.G430G|APLP1_uc010xta.1_Silent_p.G520G	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	526	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGGGGTAGGGTCCACAGAAC	0.308													0	0	0	0.047766	0	8	28										A	36369487	G	A	36369487	2	1	106	1	0	0	0	0	0	0	0	1	778	1275	44	2		2	APLP1	19	36369487	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	29619144	36369487	22759496	89	32682										
ACTN4	81	broad.mit.edu	37	chr19	39191751	39191751	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggcgtcaagctggtctccatCggggcagaaggtgagctgga	17	9	2	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:39191751C>T	uc002oja.1	+	3	446	c.387C>T	c.(385-387)ATC>ATT	p.I129I	ACTN4_uc010egc.1_Silent_p.I129I	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	129	Actin-binding.|CH 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGGTCTCCATCGGGGCAGAAG	0.532													0	0	0	0.160694	0	16	30										T	39191751	C	T	39191751	2	4	106	1	0	0	0	0	0	0	0	1	207	874	31	1		1	ACTN4	19	39191751	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	2822264	39191751	19937232	90	32683										
NKPD1	284353	broad.mit.edu	37	chr19	45656276	45656276	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	agcagcgtgttgatggcgttGagcacgcccaccacgcgctc	13	14	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:45656276G>C	uc010xxi.1	-	4	1419	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		TGATGGCGTTGAGCACGCCCA	0.672													0	0	0	0.115264	0	3	7										C	45656276	G	C	45656276	2	2	106	1	0	0	0	0	0	0	0	1	10446	1277	45	1		1	NKPD1	19	45656276	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	6464525	45656276	13472707	91	32684										
NKPD1	284353	broad.mit.edu	37	chr19	45656867	45656867	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gcgctaaagcggatgaaaagGaactgcacgttcctgcgccg	13	11	0	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:45656867G>T	uc010xxi.1	-	4	828	c.828C>A	c.(826-828)TTC>TTA	p.F276L		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		GGATGAAAAGGAACTGCACGT	0.662													1	0	0.00024832	0.150653	0.000261795	3	7										T	45656867	G	T	45656867	3	4	106	1	0	0	0	0	1	0	0	0	10446	1165	41	3	1674	3	NKPD1	19	45656867	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	591	45656867	13472116	92	32685										
SAE1	10055	broad.mit.edu	37	chr19	47646815	47646815	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gggctgaaattgccaagaatCtcatcttggcaggagtgaaa	12	7	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:47646815C>T	uc002pgc.2	+	2	219	c.163C>T	c.(163-165)CTC>TTC	p.L55F	SAE1_uc002pgd.2_Missense_Mutation_p.L55F|SAE1_uc010ekx.2_Missense_Mutation_p.L55F|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_5'UTR|SAE1_uc002pge.2_5'UTR	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	55					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TGCCAAGAATCTCATCTTGGC	0.522													0	0	0	0.189662	0	17	80										T	47646815	C	T	47646815	3	4	106	1	0	0	0	0	1	0	0	0	13805	913	32	1	169	1	SAE1	19	47646815	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	1989948	47646815	11482168	93	32686										
CLEC11A	6320	broad.mit.edu	37	chr19	51228559	51228559	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gcctggcatcgctcaccccgCcccgagctcggcgcccagcc	11	22	1	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:51228559C>T	uc002psy.2	+	4	985	c.807C>T	c.(805-807)CGC>CGT	p.R269R		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	269	C-type lectin.				positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCTCACCCCGCCCCGAGCTCG	0.726													0	0	0	0.069234	0	9	7										T	51228559	C	T	51228559	2	4	106	1	0	0	0	0	0	0	0	1	3496	726	26	2		2	CLEC11A	19	51228559	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	3581744	51228559	7900424	94	32687										
ZNF615	284370	broad.mit.edu	37	chr19	52498046	52498046	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cacactcttctgaatactttGattttgcaagtgatgctgca	7	9	2	3			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:52498046G>A	uc002pye.1	-	6	575	c.283C>T	c.(283-285)CAA>TAA	p.Q95*	ZNF615_uc002pyf.1_Nonsense_Mutation_p.Q106*|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Nonsense_Mutation_p.Q106*|ZNF615_uc010epi.1_Nonsense_Mutation_p.Q102*|ZNF615_uc010ydg.1_Nonsense_Mutation_p.Q100*	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGAATACTTTGATTTTGCAAG	0.348													0	0	0	0.249174	0	20	20										A	52498046	G	A	52498046	4	1	106	1	0	0	0	0	0	1	0	0	18037	1299	45	1	1916	1	ZNF615	19	52498046	Nonsense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	1269487	52498046	6630937	95	32688										
VSTM1	284415	broad.mit.edu	37	chr19	54544246	54544246	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gtgccgcatattcatgagatCctgggggctcctgggtggtg	16	9	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:54544246C>A	uc002qcw.3	-	9	856	c.680G>T	c.(679-681)GGA>GTA	p.G227V	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Missense_Mutation_p.G196V	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	227						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TTCATGAGATCCTGGGGGCTC	0.557													1	0	1.5739e-10	0.146539	1.79874e-10	15	14										A	54544246	C	A	54544246	3	1	106	1	0	0	0	0	1	0	0	0	17225	855	30	3	34	3	VSTM1	19	54544246	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	2046200	54544246	4584737	96	32689										
FIZ1	84922	broad.mit.edu	37	chr19	56104596	56104596	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tccagcagcgcgggcgcgttGaagtcgcgctcgcagcgcgg	17	14	0	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr19:56104596G>A	uc002qli.3	-	3	801	c.711C>T	c.(709-711)TTC>TTT	p.F237F	FIZ1_uc002qlj.3_Silent_p.F237F	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	237	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CGGGCGCGTTGAAGTCGCGCT	0.587													0	0	0	0.150653	0	3	4										A	56104596	G	A	56104596	2	1	106	1	0	0	0	0	0	0	0	1	5900	1281	45	1		1	FIZ1	19	56104596	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	1560350	56104596	3024387	97	32690										
ASXL1	171023	broad.mit.edu	37	chr20	31024350	31024350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ctcgtttctcatctccaaatGtgatctcctttggtccagag	7	12	3	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr20:31024350G>A	uc002wxs.2	+	12	4261	c.3835G>A	c.(3835-3837)GTG>ATG	p.V1279M	ASXL1_uc010geb.2_Missense_Mutation_p.V1170M	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1279					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						ATCTCCAAATGTGATCTCCTT	0.512			F|N|Mis		MDS|CMML								0	0	0	0.173368	0	36	26										A	31024350	G	A	31024350	3	1	106	1	0	0	0	0	1	0	0	0	1066	1377	48	2	3891	2	ASXL1	20	31024350	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		31024350	32001170	98	32691										
PHF20	51230	broad.mit.edu	37	chr20	34389477	34389477	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ccacctaacagacgaggaatCagctttgaagtgggagccca	11	11	1	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr20:34389477C>T	uc002xek.1	+	2	144	c.33C>T	c.(31-33)ATC>ATT	p.I11I	PHF20_uc002xei.1_Silent_p.I11I|PHF20_uc010gfo.1_Silent_p.I11I|PHF20_uc002xej.1_5'UTR|PHF20_uc002xeh.2_RNA	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					GACGAGGAATCAGCTTTGAAG	0.398													0	0	0	0.11911	0	12	36										T	34389477	C	T	34389477	2	4	106	1	0	0	0	0	0	0	0	1	11831	816	29	1		1	PHF20	20	34389477	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	3365127	34389477	28636043	99	32692										
PCK1	5105	broad.mit.edu	37	chr20	56137883	56137883	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tgacgcggatgggcacgcccGtcctggaagcagtgggcgat	17	11	0	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr20:56137883G>A	uc002xyn.3	+	4	701	c.538G>A	c.(538-540)GTC>ATC	p.V180I	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	180					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGGCACGCCCGTCCTGGAAGC	0.562													0	0	0	0.248553	0	5	37										A	56137883	G	A	56137883	3	1	106	1	0	0	0	0	1	0	0	0	11581	1145	40	2	548	2	PCK1	20	56137883	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	21748406	56137883	6887637	100	32693										
MRAP	56246	broad.mit.edu	37	chr21	33671325	33671325	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ctgccccatactacagctatGaatactacctggactatctg	6	13	1	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:33671325G>A	uc002ypj.2	+	3	230	c.43G>A	c.(43-45)GAA>AAA	p.E15K	MRAP_uc002ypk.2_Missense_Mutation_p.E15K|MRAP_uc011ado.1_Intron|MRAP_uc002ypl.2_Missense_Mutation_p.E15K	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	15	Cytoplasmic (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CTACAGCTATGAATACTACCT	0.597													0	0	0	0.038147	0	7	28										A	33671325	G	A	33671325	3	1	106	1	0	0	0	0	1	0	0	0	9753	1291	45	1	45	1	MRAP	21	33671325	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08		33671325	14458570	101	32694										
DSCAM	1826	broad.mit.edu	37	chr21	41452089	41452089	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gcatacctaccttttcctaaGgtctttgcttctatgatttc	5	11	2	1			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:41452089G>T	uc002yyq.1	-	25	4862	c.4410C>A	c.(4408-4410)ACC>ACA	p.T1470T	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1470	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTTTTCCTAAGGTCTTTGCTT	0.428													1	0	0.00307968	0.038147	0.00314915	8	92										T	41452089	G	T	41452089	2	4	106	1	0	0	0	0	0	0	0	1	4768	987	35	4		4	DSCAM	21	41452089	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	7780764	41452089	6677806	102	32695										
COL18A1	80781	broad.mit.edu	37	chr21	46875522	46875522	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gctgcccgggccaacctgctGaacctgaactggctttggtt	12	13	0	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:46875522G>C	uc011afs.1	+	1	99	c.78G>C	c.(76-78)CTG>CTC	p.L26L	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.L26L	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	26					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CCAACCTGCTGAACCTGAACT	0.642													0	0	0	0.219247	0	20	92										C	46875522	G	C	46875522	2	2	106	1	0	0	0	0	0	0	0	1	3675	1277	45	1		1	COL18A1	21	46875522	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	5423433	46875522	1254373	103	32696										
PCNT	5116	broad.mit.edu	37	chr21	47847643	47847643	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	gttgagctgcagccccgactCagtggctcagatctgggggg	16	11	3	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr21:47847643C>T	uc002zji.3	+	34	7535	c.7428C>T	c.(7426-7428)CTC>CTT	p.L2476L	PCNT_uc002zjj.2_Silent_p.L2358L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2476					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AGCCCCGACTCAGTGGCTCAG	0.602													0	0	0	0.11911	0	14	71										T	47847643	C	T	47847643	2	4	106	1	0	0	0	0	0	0	0	1	11590	813	29	1		1	PCNT	21	47847643	Silent	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	972121	47847643	282252	104	32697										
SCARF2	91179	broad.mit.edu	37	chr22	20785803	20785803	+	Frame_Shift_Del	DEL	C	C	-													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	acagctccttgcagtcggggCcccagaactggcgcgggcac							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr22:20785803delC	uc002zsj.1	-	4	461	c.356delG	c.(355-357)GGCfs	p.G119fs	SCARF2_uc002zsk.1_Frame_Shift_Del_p.G119fs	NM_153334	NP_699165	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2 isoform 1	119	Extracellular (Potential).				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCAGTCGGGGCCCCAGAACTG	0.716																		2	4	---	---								-	20785803	C	-	20785803	7	5	106	1	0	1	0	1	0	0	0	0	13884	739	26	0	2288	0	SCARF2	22	20785803	Frame_Shift_Del	DEL	C	TCGA-GC-A3RD-01A-12D-A22Z-08		20785803	30518763	105	32698										
RBM9	23543	broad.mit.edu	37	chr22	36141976	36141976	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tattatatacttaccacagcGccaactccatagctagcggc	6	13	0	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr22:36141976G>A	uc003aon.3	-	13	1417	c.1305C>T	c.(1303-1305)GGC>GGT	p.G435G	RBM9_uc003aog.3_Silent_p.G341G|RBM9_uc003aol.3_Silent_p.G360G|RBM9_uc003aoj.3_Silent_p.G364G|RBM9_uc003aok.3_Missense_Mutation_p.A348V|RBM9_uc003aoh.3_Missense_Mutation_p.A351V|RBM9_uc003aom.3_Silent_p.G342G|RBM9_uc010gwu.2_Missense_Mutation_p.A351V|RBM9_uc003aoo.3_Silent_p.G434G	NM_001082578	NP_001076047	O43251	RFOX2_HUMAN	RNA binding motif protein 9 isoform 5	374	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding				0						TTACCACAGCGCCAACTCCAT	0.443													0	0	0	0.219247	0	17	269										A	36141976	G	A	36141976	2	1	106	1	0	0	0	0	0	0	0	1	13147	1087	38	2		2	RBM9	22	36141976	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	15356173	36141976	15162590	106	32699										
CELSR1	9620	broad.mit.edu	37	chr22	46765614	46765614	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	taacagctccgatgggccccGcaaagctccaaatcagggtg	11	13	1	0	rs62226999		TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chr22:46765614G>A	uc003bhw.1	-	26	7847	c.7847C>T	c.(7846-7848)GCG>GTG	p.A2616V	CELSR1_uc011arc.1_Silent_p.C1081C	NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2616	Helical; Name=5; (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GATGGGCCCCGCAAAGCTCCA	0.622													0	0	0	0.217242	0	6	27										A	46765614	G	A	46765614	3	1	106	1	0	0	0	0	1	0	0	0	3221	1087	38	2	1237	2	CELSR1	22	46765614	Missense_Mutation	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	10623638	46765614	4538952	107	32700										
ARSD	414	broad.mit.edu	37	chrX	2825476	2825476	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggcacctacccttgctatcaCggcgtggtacaggggctcgg	14	13	1	0			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:2825476C>T	uc004cqy.2	-	10	1694	c.1618G>A	c.(1618-1620)GTG>ATG	p.V540M	ARSD_uc004cqz.1_RNA	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	540						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTTGCTATCACGGCGTGGTAC	0.647													0	0	0	0.150653	0	4	10										T	2825476	C	T	2825476	3	4	106	1	0	0	0	0	1	0	0	0	989	536	19	2	167	2	ARSD	23	2825476	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08		2825476	152445084	108	32701										
DMD	1756	broad.mit.edu	37	chrX	32235148	32235148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	tctttatatcataatgaaaaCgccgccatttctcaacagat	4	10	3	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:32235148C>T	uc004dda.1	-	44	6567	c.6323G>A	c.(6322-6324)CGT>CAT	p.R2108H	DMD_uc004dcw.2_Missense_Mutation_p.R764H|DMD_uc004dcx.2_Missense_Mutation_p.R767H|DMD_uc004dcz.2_Missense_Mutation_p.R1985H|DMD_uc004dcy.1_Missense_Mutation_p.R2104H|DMD_uc004ddb.1_Missense_Mutation_p.R2100H|DMD_uc010ngo.1_Missense_Mutation_p.R17H|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2108	Spectrin 15.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATAATGAAAACGCCGCCATTT	0.348													0	0	0	0.11911	0	13	11										T	32235148	C	T	32235148	3	4	106	1	0	0	0	0	1	0	0	0	4580	536	19	2	5026	2	DMD	23	32235148	Missense_Mutation	SNP	C	TCGA-GC-A3RD-01A-12D-A22Z-08	29409672	32235148	123035412	109	32702										
KIAA1210	57481	broad.mit.edu	37	chrX	118223492	118223492	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	ggtgaagacccagctctatcGcccaggccatacccttcact	8	16	2	2			TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:118223492G>A	uc004era.3	-	11	1701	c.1701C>T	c.(1699-1701)GGC>GGT	p.G567G		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	567										ovary(4)|skin(1)	5						CAGCTCTATCGCCCAGGCCAT	0.473													0	0	0	0.108266	0	28	47										A	118223492	G	A	118223492	2	1	106	1	0	0	0	0	0	0	0	1	8214	1074	38	2		2	KIAA1210	23	118223492	Silent	SNP	G	TCGA-GC-A3RD-01A-12D-A22Z-08	85988344	118223492	37047068	110	32703										
CUL4B	8450	broad.mit.edu	37	chrX	119679350	119679350	+	Frame_Shift_Del	DEL	A	A	-													0.333333333333333	37	1.5180225067665e-11	3.34541666666667	4.82222222222222	2.91666666666667	0.0073503357117037	0.0245011190390123	26	cgtaagttctatccagaaacAaaaaaatgctcctgatcatg							TCGA-GC-A3RD-01A-12D-A22Z-08	TCGA-GC-A3RD-10B-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7646cdea-bd75-4370-afef-81a8a0b6f194	05d7becd-5cf5-4f96-8a57-e211e00071f9	g.chrX:119679350delA	uc004esw.2	-	7	1360	c.923delT	c.(922-924)TTGfs	p.L308fs	CUL4B_uc010nqq.2_Frame_Shift_Del_p.L7fs|CUL4B_uc004esv.2_Frame_Shift_Del_p.L290fs	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	308					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						ATCCAGAAACAAAAAAATGCT	0.308																		2	4	---	---								-	119679350	A	-	119679350	7	5	106	1	0	1	0	1	0	0	0	0	4058	131	5	0	1882	0	CUL4B	23	119679350	Frame_Shift_Del	DEL	A	TCGA-GC-A3RD-01A-12D-A22Z-08	1455858	119679350	35591210	111	32704										
UBR4	23352	broad.mit.edu	37	chr1	19487443	19487443	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttcctcccggcagccctctaCtgtgcggcagaggctgctct	11	16	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:19487443C>T	uc001bbi.2	-	38	5378	c.5374G>A	c.(5374-5376)GTA>ATA	p.V1792I	UBR4_uc001bbm.1_Missense_Mutation_p.V1003I	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1792					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGCCCTCTACTGTGCGGCAG	0.542													0	0	0	0.001984	0	7	46										T	19487443	C	T	19487443	3	4	107	1	0	0	0	0	1	0	0	0	16901	565	20	2	10453	2	UBR4	1	19487443	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08		19487443	229763178	1	32705										
MRTO4	51154	broad.mit.edu	37	chr1	19584362	19584362	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cacagaaatggactacgcccGagctggtaacaaagcagctt	10	11	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:19584362G>C	uc001bbs.2	+	6	632	c.377G>C	c.(376-378)CGA>CCA	p.R126P		NM_016183	NP_057267	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog	126					ribosome biogenesis	nuclear membrane|nucleolus					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GACTACGCCCGAGCTGGTAAC	0.592													0	0	0	0.014323	0	23	123										C	19584362	G	C	19584362	3	2	107	1	0	0	0	0	1	0	0	0	9852	1058	37	1	399	1	MRTO4	1	19584362	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	96919	19584362	229666259	2	32706										
TAF12	6883	broad.mit.edu	37	chr1	28931969	28931969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggatccacatgttccactggCgctctgcaaggaagaagcca	11	12	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:28931969C>T	uc001bqw.2	-	4	458	c.365G>A	c.(364-366)CGC>CAC	p.R122H	TAF12_uc001bqx.2_Missense_Mutation_p.R122H|TAF12_uc001bqy.2_Missense_Mutation_p.R122H|TAF12_uc009vti.2_Missense_Mutation_p.R122H	NM_005644	NP_005635	Q16514	TAF12_HUMAN	TAF12 RNA polymerase II, TATA box binding	122					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Renal(390;0.00121)|Breast(348;0.00502)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)		Colorectal(126;3.21e-08)|COAD - Colon adenocarcinoma(152;1.74e-06)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(1967;0.0109)|BRCA - Breast invasive adenocarcinoma(304;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		GTTCCACTGGCGCTCTGCAAG	0.512													0	0	0	0.020292	0	14	80										T	28931969	C	T	28931969	3	4	107	1	0	0	0	0	1	0	0	0	15513	768	27	2	128	2	TAF12	1	28931969	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	9347607	28931969	220318652	3	32707										
DMRTA2	63950	broad.mit.edu	37	chr1	50884577	50884577	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	taggccaggcgcagggggctGaggccgagcggcgcgcccag	20	13	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:50884577G>A	uc010ona.1	-	2	1485	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	DMRTA2_uc010onb.1_Silent_p.L463L	NM_032110	NP_115486	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	463	Ala-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						GCAGGGGGCTGAGGCCGAGCG	0.756													0	0	0	0.021553	0	6	6										A	50884577	G	A	50884577	2	1	107	1	0	0	0	0	0	0	0	1	4589	1277	45	1		1	DMRTA2	1	50884577	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	21952608	50884577	198366044	4	32708										
LPPR4	9890	broad.mit.edu	37	chr1	99771657	99771657	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aatgaaagtcgaaagttgtcCttgcaagttatagagcctga	10	6	0	3	rs35971915		TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:99771657C>T	uc001dse.2	+	7	1489	c.1383C>T	c.(1381-1383)TCC>TCT	p.S461S	LPPR4_uc010oue.1_Silent_p.S403S	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	461							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GAAAGTTGTCCTTGCAAGTTA	0.502													0	0	0	0.023175	0	39	94										T	99771657	C	T	99771657	2	4	107	1	0	0	0	0	0	0	0	1	8927	668	24	2		2	LPPR4	1	99771657	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	48887080	99771657	149478964	5	32709										
OLFM3	118427	broad.mit.edu	37	chr1	102312479	102312479	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgggacatccagtttgagatCattgccatggtactaagcac	10	9	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:102312479C>G	uc001duf.2	-	1	122	c.51G>C	c.(49-51)ATG>ATC	p.M17I	OLFM3_uc001dug.2_Intron|OLFM3_uc001duh.2_Intron|OLFM3_uc001dui.2_Intron|OLFM3_uc001duj.2_Intron|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	17						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGTTTGAGATCATTGCCATGG	0.507													0	0	0	0.014323	0	24	91										G	102312479	C	G	102312479	3	3	107	1	0	0	0	0	1	0	0	0	10854	841	29	1		1	OLFM3	1	102312479	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	2540822	102312479	146938142	6	32710										
FAM40A	85369	broad.mit.edu	37	chr1	110581817	110581817	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cagacaagaagtggactgagCtggataccaaccagcaccgg	12	11	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:110581817C>T	uc001dza.1	+	4	368	c.349C>T	c.(349-351)CTG>TTG	p.L117L	FAM40A_uc001dyz.1_Silent_p.L22L|FAM40A_uc009wfp.1_5'UTR	NM_033088	NP_149079	Q5VSL9	FA40A_HUMAN	hypothetical protein LOC85369	117						nucleus	protein binding			ovary(3)|large_intestine(1)	4		all_cancers(81;8.51e-05)|all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0154)|all cancers(265;0.0732)|Epithelial(280;0.0781)|Colorectal(144;0.115)|LUSC - Lung squamous cell carcinoma(189;0.137)		GTGGACTGAGCTGGATACCAA	0.517													0	0	0	0.013537	0	13	46										T	110581817	C	T	110581817	2	4	107	1	0	0	0	0	0	0	0	1	5560	796	28	2		2	FAM40A	1	110581817	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	8269338	110581817	138668804	7	32711										
TXNIP	10628	broad.mit.edu	37	chr1	145438895	145438895	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gagaaggtggctggccgggtGatagtggaggtgtgtgaagt	21	3	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:145438895G>C	uc001enn.3	+	1	434	c.93G>C	c.(91-93)GTG>GTC	p.V31V	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_5'Flank	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	31					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTGGCCGGGTGATAGTGGAGG	0.517													0	0	0	0.001984	0	7	91										C	145438895	G	C	145438895	2	2	107	1	0	0	0	0	0	0	0	1	16800	1277	45	1		1	TXNIP	1	145438895	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	34857078	145438895	103811726	8	32712			1	148		3	3	1380	G		2.95214e-05
TXNIP	10628	broad.mit.edu	37	chr1	145439609	145439609	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tcaggtgagaatgagatggtGatcatgagacctggaaacaa	13	5	2	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:145439609G>C	uc001enn.3	+	2	608	c.267G>C	c.(265-267)GTG>GTC	p.V89V	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Silent_p.V34V	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	89					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATGAGATGGTGATCATGAGAC	0.403													0	0	0	0.007413	0	17	131										C	145439609	G	C	145439609	2	2	107	1	0	0	0	0	0	0	0	1	16800	1277	45	1		1	TXNIP	1	145439609	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	714	145439609	103811012	9	32713			1	148		3	3	1380	G		2.95214e-05
TXNIP	10628	broad.mit.edu	37	chr1	145440274	145440274	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctttctcattgctaggtgatGagatttccatccatgctgac	8	10	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:145440274G>A	uc001enn.3	+	5	921	c.580G>A	c.(580-582)GAG>AAG	p.E194K	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.E139K	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	194					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCTAGGTGATGAGATTTCCAT	0.478													0	0	0	0.012319	0	21	149										A	145440274	G	A	145440274	3	1	107	1	0	0	0	0	1	0	0	0	16800	1291	45	1	598	1	TXNIP	1	145440274	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	665	145440274	103810347	10	32714			1	148		3	3	1380	G		2.95214e-05
PIAS3	10401	broad.mit.edu	37	chr1	145584822	145584822	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tagatttattttcatttcttCagacagagagtcaggtaagt	8	5	4	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:145584822C>A	uc001eoc.1	+	13	1697	c.1606C>A	c.(1606-1608)CAG>AAG	p.Q536K	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_Missense_Mutation_p.Q205K	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	536					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCATTTCTTCAGACAGAGAG	0.423													1	0	7.11191e-15	0.013726	7.61477e-15	30	76										A	145584822	C	A	145584822	3	1	107	1	0	0	0	0	1	0	0	0	11877	827	29	3	1656	3	PIAS3	1	145584822	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	144548	145584822	103665799	11	32715										
SETDB1	9869	broad.mit.edu	37	chr1	150923371	150923371	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggaccgaaagtttcagccctAtaagcctttttactatattt	6	9	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:150923371A>G	uc001evu.2	+	13	2208	c.2018A>G	c.(2017-2019)TAT>TGT	p.Y673C	SETDB1_uc009wmf.2_Missense_Mutation_p.Y674C|SETDB1_uc001evv.2_Missense_Mutation_p.Y673C|SETDB1_uc009wmg.1_Missense_Mutation_p.Y673C	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTTCAGCCCTATAAGCCTTTT	0.463													0	0	0	0.012213	0	35	83										G	150923371	A	G	150923371	3	3	107	1	0	0	0	0	1	0	0	0	14138	449	16	5	2064	5	SETDB1	1	150923371	Missense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	5338549	150923371	98327250	12	32716										
SEMA6C	10500	broad.mit.edu	37	chr1	151108092	151108092	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agggctgtaggcatcaatctCttccaggaggatgggctcag	14	9	3	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:151108092C>G	uc001ewu.2	-	14	1708	c.1408G>C	c.(1408-1410)GAG>CAG	p.E470Q	SEMA6C_uc001ewv.2_Missense_Mutation_p.E470Q|SEMA6C_uc001eww.2_Missense_Mutation_p.E430Q|SEMA6C_uc010pcq.1_Missense_Mutation_p.E470Q	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	470	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCATCAATCTCTTCCAGGAGG	0.602													0	0	0	0.01441	0	67	122										G	151108092	C	G	151108092	3	3	107	1	0	0	0	0	1	0	0	0	14041	922	32	1	1508	1	SEMA6C	1	151108092	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	184721	151108092	98142529	13	32717										
NUP210L	91181	broad.mit.edu	37	chr1	154112367	154112367	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cacatctccttgtttctcctCtttttccatctcagctatat	2	14	4	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:154112367C>G	uc001fdw.2	-	5	700	c.628G>C	c.(628-630)GAG>CAG	p.E210Q	NUP210L_uc010peh.1_Missense_Mutation_p.E210Q	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	210						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TGTTTCTCCTCTTTTTCCATC	0.338													0	0	0	0.01441	0	105	243										G	154112367	C	G	154112367	3	3	107	1	0	0	0	0	1	0	0	0	10761	922	32	1	5182	1	NUP210L	1	154112367	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	3004275	154112367	95138254	14	32718										
FMOD	2331	broad.mit.edu	37	chr1	203316731	203316731	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggtccagcaagatcagtgacCggaggcccctcatggaactg	13	12	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:203316731C>T	uc001gzr.2	-	2	804	c.668G>A	c.(667-669)CGG>CAG	p.R223Q	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	223					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			GATCAGTGACCGGAGGCCCCT	0.567													0	0	0	0.01441	0	72	189										T	203316731	C	T	203316731	3	4	107	1	0	0	0	0	1	0	0	0	5959	652	23	2	470	2	FMOD	1	203316731	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	49204364	203316731	45933890	15	32719										
PTPN14	5784	broad.mit.edu	37	chr1	214567095	214567095	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtgtggcaaacaaccgagaaAtatacttggcattttcgata	9	7	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:214567095A>C	uc001hkk.1	-	10	1143	c.872T>G	c.(871-873)ATT>AGT	p.I291S	PTPN14_uc010pty.1_Missense_Mutation_p.I192S	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	291	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CAACCGAGAAATATACTTGGC	0.343													0	0	0	0.021523	0	20	67										C	214567095	A	C	214567095	3	2	107	1	0	0	0	0	1	0	0	0	12783	101	4	5	2731	5	PTPN14	1	214567095	Missense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	11250364	214567095	34683526	16	32720										
JMJD4	65094	broad.mit.edu	37	chr1	227921241	227921241	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgtgtgtcgcagagtgctggGgaggtcacgtcgtagggcag	19	7	1	1	rs117793265	by1000genomes	TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:227921241G>A	uc001hrb.2	-	4	834	c.834C>T	c.(832-834)TCC>TCT	p.S278S	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Silent_p.S278S	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	278	JmjC.										0		Prostate(94;0.0885)				AGAGTGCTGGGGAGGTCACGT	0.642													0	0	0	0.012319	0	21	61										A	227921241	G	A	227921241	2	1	107	1	0	0	0	0	0	0	0	1	7951	1219	43	2		2	JMJD4	1	227921241	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	13354146	227921241	21329380	17	32721										
OBSCN	84033	broad.mit.edu	37	chr1	228473945	228473945	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aatgagatcgatgcccagccCgggggctaccacgtgctgac	13	13	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr1:228473945C>T	uc009xez.1	+	34	9215	c.9171C>T	c.(9169-9171)CCC>CCT	p.P3057P	OBSCN_uc001hsn.2_Silent_p.P3057P|OBSCN_uc001hsq.1_Silent_p.P313P	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3057	Ig-like 30.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ATGCCCAGCCCGGGGGCTACC	0.667													0	0	0	0.021553	0	6	26										T	228473945	C	T	228473945	2	4	107	1	0	0	0	0	0	0	0	1	10812	639	23	2		2	OBSCN	1	228473945	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	552704	228473945	20776676	18	32722										
ADAM17	6868	broad.mit.edu	37	chr2	9637283	9637283	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agctgctgttccctctcgcaGaaagggatgcatttcccatc	9	13	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:9637283G>A	uc002qzu.2	-	14	1926	c.1743C>T	c.(1741-1743)TTC>TTT	p.F581F	ADAM17_uc010ewy.2_Silent_p.F581F|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	581	Extracellular (Potential).|Cys-rich.				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CCCTCTCGCAGAAAGGGATGC	0.507													0	0	0	0.008361	0	31	79										A	9637283	G	A	9637283	2	1	107	1	0	0	0	0	0	0	0	1	238	933	33	1		1	ADAM17	2	9637283	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		9637283	233562090	19	32723										
IFT172	26160	broad.mit.edu	37	chr2	27706492	27706492	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	actctgtcccatagatggtaGatgatttattagttttggtg	10	5	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:27706492G>C	uc002rku.2	-	6	488	c.437C>G	c.(436-438)TCT>TGT	p.S146C	IFT172_uc002rkw.2_Missense_Mutation_p.S146C|IFT172_uc010yls.1_Missense_Mutation_p.S125C|IFT172_uc010ezc.2_Missense_Mutation_p.S146C|IFT172_uc002rkv.2_Missense_Mutation_p.S146C	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	146	WD 3.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					ATAGATGGTAGATGATTTATT	0.368													0	0	0	0.00499	0	16	47										C	27706492	G	C	27706492	3	2	107	1	0	0	0	0	1	0	0	0	7557	942	33	1	4984	1	IFT172	2	27706492	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	18069209	27706492	215492881	20	32724										
SPTBN1	6711	broad.mit.edu	37	chr2	54870186	54870186	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cttacgatgaagccagaaatCtgcacagtaaatggttgaag	10	7	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:54870186C>G	uc002rxu.2	+	19	4174	c.3925C>G	c.(3925-3927)CTG>GTG	p.L1309V	SPTBN1_uc002rxx.2_Missense_Mutation_p.L1296V	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1309	Spectrin 10.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGCCAGAAATCTGCACAGTAA	0.413													0	0	0	0.00499	0	18	92										G	54870186	C	G	54870186	3	3	107	1	0	0	0	0	1	0	0	0	15118	912	32	1	4108	1	SPTBN1	2	54870186	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	27163694	54870186	188329187	21	32725										
LONRF2	164832	broad.mit.edu	37	chr2	100903457	100903457	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cgatcctggagagacgcgaaCcaggaaacagactgttgatg	13	9	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:100903457C>G	uc002tal.3	-	11	2629	c.1989G>C	c.(1987-1989)TGG>TGC	p.W663C	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	663	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						GAGACGCGAACCAGGAAACAG	0.498													0	0	0	0.006214	0	10	67										G	100903457	C	G	100903457	3	3	107	1	0	0	0	0	1	0	0	0	8895	508	18	4	283	4	LONRF2	2	100903457	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	46033271	100903457	142295916	22	32726										
ARHGEF4	50649	broad.mit.edu	37	chr2	131704110	131704110	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aaagacgatcattacctctcCagagtctttgaatctcccta	5	12	4	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:131704110C>T	uc002tsa.1	+	4	849	c.329C>T	c.(328-330)CCA>CTA	p.P110L	ARHGEF4_uc010fmw.1_Missense_Mutation_p.P756L|ARHGEF4_uc002tsb.1_Missense_Mutation_p.P110L|ARHGEF4_uc010fmx.1_Missense_Mutation_p.P110L|ARHGEF4_uc002trz.1_Missense_Mutation_p.P756L	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	110	ABR (APC-binding region) domain.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		ATTACCTCTCCAGAGTCTTTG	0.522													0	0	0	0.006122	0	18	129										T	131704110	C	T	131704110	3	4	107	1	0	0	0	0	1	0	0	0	908	594	21	2	335	2	ARHGEF4	2	131704110	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	30800653	131704110	111495263	23	32727										
TTN	7273	broad.mit.edu	37	chr2	179666927	179666927	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cattggtggctttcagggaaTatcgtccactgttggcttta	11	8	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:179666927T>C	uc002und.2	-	3	458	c.233A>G	c.(232-234)TAT>TGT	p.Y78C	TTN_uc010zfg.1_Missense_Mutation_p.Y78C|TTN_uc010zfh.1_Missense_Mutation_p.Y78C|TTN_uc010zfi.1_Missense_Mutation_p.Y78C|TTN_uc010zfj.1_Missense_Mutation_p.Y78C|TTN_uc002unb.2_Missense_Mutation_p.Y78C			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	78							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGGGAATATCGTCCACT	0.562													0	0	0	0.01892	0	21	108										C	179666927	T	C	179666927	3	2	107	1	0	0	0	0	1	0	0	0	16732	1406	49	5	111195	5	TTN	2	179666927	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	47962817	179666927	63532446	24	32728										
MFF	56947	broad.mit.edu	37	chr2	228195544	228195544	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtgtgataatgcaagttccgGagaggattgttgtagcaggt	15	4	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr2:228195544G>A	uc002vos.2	+	4	659	c.241G>A	c.(241-243)GAG>AAG	p.E81K	MFF_uc002vot.2_Missense_Mutation_p.E55K|MFF_uc002vou.2_Missense_Mutation_p.E81K|MFF_uc002vov.2_Missense_Mutation_p.E55K|MFF_uc002vow.2_Missense_Mutation_p.E55K|MFF_uc002vox.2_Missense_Mutation_p.E55K|MFF_uc002voy.2_Missense_Mutation_p.E81K|MFF_uc002voz.2_Missense_Mutation_p.E55K	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	81	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						GCAAGTTCCGGAGAGGATTGT	0.388													0	0	0	0.006214	0	9	29										A	228195544	G	A	228195544	3	1	107	1	0	0	0	0	1	0	0	0	9519	1175	41	1	247	1	MFF	2	228195544	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	48528617	228195544	15003829	25	32729										
ZNF660	285349	broad.mit.edu	37	chr3	44635868	44635868	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgtgggaaagcctttagtcaGagtgcaaacctcacagtaca	10	9	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:44635868G>C	uc003cnl.1	+	3	516	c.183G>C	c.(181-183)CAG>CAC	p.Q61H		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	61	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		CCTTTAGTCAGAGTGCAAACC	0.438													0	0	0	0.016723	0	14	42										C	44635868	G	C	44635868	3	2	107	1	0	0	0	0	1	0	0	0	18067	933	33	1	185	1	ZNF660	3	44635868	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		44635868	153386562	26	32730										
ZNF660	285349	broad.mit.edu	37	chr3	44635933	44635933	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	accctataagtgtaaggagtGtggaaaagctttcagtcata	10	6	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:44635933G>C	uc003cnl.1	+	3	581	c.248G>C	c.(247-249)TGT>TCT	p.C83S		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	83	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TGTAAGGAGTGTGGAAAAGCT	0.443													0	0	0	0.00499	0	15	44										C	44635933	G	C	44635933	3	2	107	1	0	0	0	0	1	0	0	0	18067	1377	48	4	250	4	ZNF660	3	44635933	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	65	44635933	153386497	27	32731										
PRICKLE2	166336	broad.mit.edu	37	chr3	64132828	64132828	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gagctccttttggggttgctGaagtgcttgccccacatttc	11	11	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:64132828G>A	uc003dmf.2	-	7	1924	c.1338C>T	c.(1336-1338)TTC>TTT	p.F446F		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	446						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		TGGGGTTGCTGAAGTGCTTGC	0.582													0	0	0	0.008361	0	30	79										A	64132828	G	A	64132828	2	1	107	1	0	0	0	0	0	0	0	1	12487	1281	45	1		1	PRICKLE2	3	64132828	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	19496895	64132828	133889602	28	32732										
ABI3BP	25890	broad.mit.edu	37	chr3	100566463	100566463	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tacccggtgttgtccatgtaGgttcagggcttttagaaatt	11	7	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:100566463G>A	uc003dun.2	-	17	1590	c.1505C>T	c.(1504-1506)CCT>CTT	p.P502L	ABI3BP_uc003duo.2_Missense_Mutation_p.P544L|ABI3BP_uc011bhd.1_5'Flank|ABI3BP_uc003dum.2_5'Flank	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	502	Pro-rich.					extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TGTCCATGTAGGTTCAGGGCT	0.373													0	0	0	0.01441	0	86	113										A	100566463	G	A	100566463	3	1	107	1	0	0	0	0	1	0	0	0	91	1000	35	2	1798	2	ABI3BP	3	100566463	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	36433635	100566463	97455967	29	32733										
SENP7	57337	broad.mit.edu	37	chr3	101060534	101060534	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	acttctcgccattcttcatcTggattagatgtaatagaaag	7	8	4	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:101060534T>C	uc003dut.2	-	15	2307	c.2196A>G	c.(2194-2196)CCA>CCG	p.P732P	SENP7_uc003duu.2_Silent_p.P667P|SENP7_uc003duv.2_Silent_p.P699P|SENP7_uc003duw.2_Silent_p.P666P|SENP7_uc003dux.2_Silent_p.P568P	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	732					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						ATTCTTCATCTGGATTAGATG	0.433													0	0	0	0.027356	0	28	38										C	101060534	T	C	101060534	2	2	107	1	0	0	0	0	0	0	0	1	14051	1567	55	5		5	SENP7	3	101060534	Silent	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	494071	101060534	96961896	30	32734										
GOLIM4	27333	broad.mit.edu	37	chr3	167750586	167750586	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcatagagttttgtgtcttCtgctcttccaggaactgctt	9	9	3	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:167750586C>T	uc003ffe.2	-	9	1242	c.898G>A	c.(898-900)GAA>AAA	p.E300K	GOLIM4_uc011bpe.1_Missense_Mutation_p.E300K|GOLIM4_uc011bpf.1_Missense_Mutation_p.E272K|GOLIM4_uc011bpg.1_Missense_Mutation_p.E272K	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	300	Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TTTGTGTCTTCTGCTCTTCCA	0.483													0	0	0	0.01441	0	57	78										T	167750586	C	T	167750586	3	4	107	1	0	0	0	0	1	0	0	0	6566	922	32	1	1224	1	GOLIM4	3	167750586	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	66690052	167750586	30271844	31	32735										
PIK3CA	5290	broad.mit.edu	37	chr3	178936095	178936095	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tctctctgaaatcactgagcAggagaaagattttctatgga	9	7	4	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:178936095A>G	uc003fjk.2	+	10	1794	c.1637A>G	c.(1636-1638)CAG>CGG	p.Q546R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	546	PI3K helical.		Q -> K (in cancer).|Q -> P (in cancer).|Q -> E (in cancer).|Q -> R (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Q546K(54)|p.Q546R(17)|p.Q546P(10)|p.Q546E(9)|p.Q546L(6)|p.Q546H(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCACTGAGCAGGAGAAAGAT	0.363		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.00632	0	27	32										G	178936095	A	G	178936095	3	3	107	1	0	0	0	0	1	0	0	0	11913	188	7	5	1671	5	PIK3CA	3	178936095	Missense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	11185509	178936095	19086335	32	32736										
RFC4	5984	broad.mit.edu	37	chr3	186512453	186512453	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gcaaatttacttactctgagCgacttcctgacacagttaat	6	10	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr3:186512453C>T	uc003fqz.2	-	5	627	c.404G>A	c.(403-405)CGC>CAC	p.R135H	RFC4_uc011bsc.1_Missense_Mutation_p.R135H|RFC4_uc011bsd.1_Missense_Mutation_p.R135H	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	135					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TTACTCTGAGCGACTTCCTGA	0.303													0	0	0	0.016723	0	13	56										T	186512453	C	T	186512453	3	4	107	1	0	0	0	0	1	0	0	0	13247	768	27	2	715	2	RFC4	3	186512453	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	7576358	186512453	11509977	33	32737										
AFAP1	60312	broad.mit.edu	37	chr4	7770734	7770734	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tccggtgccggaacactggaGacttaacggagagagagaac	14	9	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr4:7770734G>A	uc003gkg.1	-	16	2276	c.2003C>T	c.(2002-2004)TCT>TTT	p.S668F	AFAP1_uc011bwk.1_Missense_Mutation_p.S752F|LOC84740_uc003gkd.3_Intron	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	668						actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0						GAACACTGGAGACTTAACGGA	0.547													0	0	0	0.013726	0	32	175										A	7770734	G	A	7770734	3	1	107	1	0	0	0	0	1	0	0	0	353	956	33	1	197	1	AFAP1	4	7770734	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		7770734	183383542	34	32738										
SEL1L3	23231	broad.mit.edu	37	chr4	25836912	25836912	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgcctgtgttttctccactgGaggcataaggaaagccaagc	11	10	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr4:25836912G>C	uc003gru.3	-	3	919	c.767C>G	c.(766-768)TCC>TGC	p.S256C		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	256						integral to membrane	binding				0						TTCTCCACTGGAGGCATAAGG	0.488													0	0	0	0.021523	0	26	100										C	25836912	G	C	25836912	3	2	107	1	0	0	0	0	1	0	0	0	14012	1174	41	1	2719	1	SEL1L3	4	25836912	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	18066178	25836912	165317364	35	32739										
COX7B2	170712	broad.mit.edu	37	chr4	46737107	46737107	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcattaccatatttatcatGaaaatctggtgagtgtttta	7	5	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr4:46737107G>C	uc003gxf.2	-	3	283	c.103C>G	c.(103-105)CAT>GAT	p.H35D	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	35	Helical; (By similarity).					integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						TATTTATCATGAAAATCTGGT	0.423													0	0	0	0.004482	0	8	76										C	46737107	G	C	46737107	3	2	107	1	0	0	0	0	1	0	0	0	3783	1290	45	1	146	1	COX7B2	4	46737107	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	20900195	46737107	144417169	36	32740										
LIN54	132660	broad.mit.edu	37	chr4	83905979	83905979	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tggaagcaaactattcacctCagctggcaccacctccatga	7	14	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr4:83905979C>T	uc003hnx.3	-	2	397	c.19G>A	c.(19-21)GAG>AAG	p.E7K	LIN54_uc003hnz.3_Missense_Mutation_p.E7K|LIN54_uc003hny.3_5'UTR|LIN54_uc010ijt.2_Missense_Mutation_p.E7K|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Missense_Mutation_p.E7K	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	7					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				CTATTCACCTCAGCTGGCACC	0.393													0	0	0	0.010771	0	42	104										T	83905979	C	T	83905979	3	4	107	1	0	0	0	0	1	0	0	0	8809	835	29	1	2278	1	LIN54	4	83905979	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	37168872	83905979	107248297	37	32741										
FHDC1	85462	broad.mit.edu	37	chr4	153864366	153864366	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	catgttcatgttcaagggaaGagtgtccttcctcccctcct	8	13	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr4:153864366G>A	uc003inf.2	+	1	232	c.157G>A	c.(157-159)GAG>AAG	p.E53K		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	53					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					TTCAAGGGAAGAGTGTCCTTC	0.458													0	0	0	0.00308	0	6	18										A	153864366	G	A	153864366	3	1	107	1	0	0	0	0	1	0	0	0	5876	943	33	1	159	1	FHDC1	4	153864366	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	69958387	153864366	37289910	38	32742										
FAT1	2195	broad.mit.edu	37	chr4	187540391	187540391	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gggcgtgccggtgcaggtttGagagggtgataatccctgtt	17	7	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr4:187540391G>C	uc003izf.2	-	10	7537	c.7349C>G	c.(7348-7350)TCA>TGA	p.S2450*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2450	Extracellular (Potential).|Cadherin 22.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTGCAGGTTTGAGAGGGTGAT	0.433										HNSCC(5;0.00058)			0	0	0	0.01892	0	25	136										C	187540391	G	C	187540391	4	2	107	1	0	0	0	0	0	1	0	0	5689	1294	45	1	6489	1	FAT1	4	187540391	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	33676025	187540391	3613885	39	32743										
KIAA0947	23379	broad.mit.edu	37	chr5	5464640	5464640	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cttcctgtgcctggccgactCccaccctgtgcatctggcca	9	18	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:5464640C>G	uc003jdm.3	+	13	5415	c.5193C>G	c.(5191-5193)CTC>CTG	p.L1731L		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1731	Pro-rich.									ovary(1)|central_nervous_system(1)	2						CTGGCCGACTCCCACCCTGTG	0.597													0	0	0	0.001984	0	7	47										G	5464640	C	G	5464640	2	3	107	1	0	0	0	0	0	0	0	1	8202	842	30	1		1	KIAA0947	5	5464640	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08		5464640	175450620	40	32744										
WDR70	55100	broad.mit.edu	37	chr5	37379600	37379600	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tcttgctccagtgacaggctCagacgcgtcgggaccggacc	13	14	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:37379600C>T	uc003jkv.2	+	2	93	c.35C>T	c.(34-36)TCA>TTA	p.S12L	WDR70_uc010iva.1_Missense_Mutation_p.S12L	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	12										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTGACAGGCTCAGACGCGTCG	0.662													0	0	0	0.016522	0	23	93										T	37379600	C	T	37379600	3	4	107	1	0	0	0	0	1	0	0	0	17318	838	29	1	41	1	WDR70	5	37379600	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	31914960	37379600	143535660	41	32745										
CCDC125	202243	broad.mit.edu	37	chr5	68603838	68603838	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	actgcctgcgtatgacttgtGgctttgcccagtattgccta	10	11	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:68603838G>A	uc003jvv.1	-	4	514	c.471C>T	c.(469-471)GCC>GCT	p.A157A	CCDC125_uc003jvx.1_Silent_p.A156A|CCDC125_uc003jvy.1_Intron|CCDC125_uc003jvw.2_Silent_p.A32A|CCDC125_uc003jvz.1_3'UTR	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	157	Potential.					cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TATGACTTGTGGCTTTGCCCA	0.333													0	0	0	0.00308	0	7	47										A	68603838	G	A	68603838	2	1	107	1	0	0	0	0	0	0	0	1	2761	1335	47	2		2	CCDC125	5	68603838	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	31224238	68603838	112311422	42	32746										
CCDC125	202243	broad.mit.edu	37	chr5	68616398	68616398	+	Translation_Start_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ccgtctttatcataagaaaaAatgggctgtctgtagttaag	9	6	3	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:68616398A>C	uc003jvv.1	-	1	13	c.-30T>G	c.(-32--28)ATTTT>ATGTT		CCDC125_uc003jvx.1_Translation_Start_Site|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_Translation_Start_Site|CCDC125_uc003jvz.1_Translation_Start_Site	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125							cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		CATAAGAAAAAATGGGCTGTC	0.308													0	0	0	0.008291	0	11	25										C	68616398	A	C	68616398	1	2	107	1	0	0	0	0	0	0	0	0	2761	29	1	5		5	CCDC125	5	68616398	Translation_Start_Site	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	12560	68616398	112298862	43	32747										
FAM169A	26049	broad.mit.edu	37	chr5	74077445	74077445	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	actgatccagttgctcggaaGatgcttcagactgctcctct	9	12	2	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:74077445G>C	uc003kdm.2	-	13	1896	c.1853C>G	c.(1852-1854)TCT>TGT	p.S618C	FAM169A_uc010izm.2_Missense_Mutation_p.S558C|FAM169A_uc003kdl.2_Missense_Mutation_p.S436C	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	618											0						TTGCTCGGAAGATGCTTCAGA	0.468													0	0	0	0.010504	0	21	134										C	74077445	G	C	74077445	3	2	107	1	0	0	0	0	1	0	0	0	5487	942	33	1	163	1	FAM169A	5	74077445	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	5461047	74077445	106837815	44	32748										
GIN1	54826	broad.mit.edu	37	chr5	102432327	102432327	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctaaccccagtgttgtctctCaggacagcacatccactttc	6	15	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:102432327C>T	uc003koa.1	-	7	1294	c.1212G>A	c.(1210-1212)CTG>CTA	p.L404L	GIN1_uc003kob.1_Silent_p.L257L|GIN1_uc003koc.1_Intron	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	404					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		TGTTGTCTCTCAGGACAGCAC	0.413													0	0	0	0.011902	0	47	179										T	102432327	C	T	102432327	2	4	107	1	0	0	0	0	0	0	0	1	6386	813	29	1		1	GIN1	5	102432327	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	28354882	102432327	78482933	45	32749										
ISOC1	51015	broad.mit.edu	37	chr5	128430720	128430720	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtggacttgcccaagggcttCgcggtgagcgagcgctgcaa	16	11	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:128430720C>T	uc003kva.2	+	1	279	c.261C>T	c.(259-261)TTC>TTT	p.F87F		NM_016048	NP_057132	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	87						peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		CCAAGGGCTTCGCGGTGAGCG	0.622													0	0	0	0.009096	0	4	23										T	128430720	C	T	128430720	2	4	107	1	0	0	0	0	0	0	0	1	7862	883	31	1		1	ISOC1	5	128430720	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	25998393	128430720	52484540	46	32750										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139838425	139838425	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cgggaaggacatgaagaaatGgtggcactactcttagcaca	12	8	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:139838425G>A	uc003lfs.1	+	8	1582	c.1458G>A	c.(1456-1458)ATG>ATA	p.M486I	ANKHD1_uc003lfq.1_Missense_Mutation_p.M486I|ANKHD1_uc003lfr.2_Missense_Mutation_p.M486I|ANKHD1_uc003lft.1_5'Flank|ANKHD1_uc003lfu.1_5'Flank|ANKHD1_uc003lfp.2_Missense_Mutation_p.M475I|ANKHD1_uc003lfo.2_Missense_Mutation_p.M486I|ANKHD1_uc010jfk.2_Missense_Mutation_p.M486I	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	486						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAAGAAATGGTGGCACTAC	0.398													0	0	0	0.008291	0	11	79										A	139838425	G	A	139838425	3	1	107	1	0	0	0	0	1	0	0	0	629	1348	47	2	1488	2	ANKHD1-EIF4EBP3	5	139838425	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	11407705	139838425	41076835	47	32751										
PCDHA11	56138	broad.mit.edu	37	chr5	140250913	140250913	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gcccacgctggtgtgctcccGcgcggtggggagctggtcat	17	13	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:140250913G>A	uc003lia.2	+	1	3083	c.2225G>A	c.(2224-2226)CGC>CAC	p.R742H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R742H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	742	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTGCTCCCGCGCGGTGGGG	0.677													0	0	0	0.020292	0	15	56										A	140250913	G	A	140250913	3	1	107	1	0	0	0	0	1	0	0	0	11521	1087	38	2	2227	2	PCDHA11	5	140250913	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	412488	140250913	40664347	48	32752										
C5orf41	153222	broad.mit.edu	37	chr5	172517948	172517948	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggcccttgttgagccagattCacacagatgcagcaaaggag	12	10	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr5:172517948C>T	uc003mch.2	+	4	1070	c.766C>T	c.(766-768)CAC>TAC	p.H256Y	C5orf41_uc003mcg.2_Missense_Mutation_p.H256Y|C5orf41_uc003mcf.2_Missense_Mutation_p.H256Y|C5orf41_uc011dfd.1_Missense_Mutation_p.H256Y	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	256							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGCCAGATTCACACAGATGC	0.468													0	0	0	0.020292	0	14	56										T	172517948	C	T	172517948	3	4	107	1	0	0	0	0	1	0	0	0	2300	826	29	1	776	1	C5orf41	5	172517948	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	32267035	172517948	8397312	49	32753										
NUP153	9972	broad.mit.edu	37	chr6	17675190	17675190	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	acagcagctgctgccccaccGtatgttgtttttccaggata	9	12	0	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:17675190G>A	uc003ncd.1	-	5	998	c.798C>T	c.(796-798)TAC>TAT	p.Y266Y	NUP153_uc011dje.1_Silent_p.Y266Y|NUP153_uc010jpl.1_Silent_p.Y266Y	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	266					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			CTGCCCCACCGTATGTTGTTT	0.373													0	0	0	0.00499	0	17	60										A	17675190	G	A	17675190	2	1	107	1	0	0	0	0	0	0	0	1	10755	1140	40	2		2	NUP153	6	17675190	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		17675190	153439877	50	32754										
GPLD1	2822	broad.mit.edu	37	chr6	24429286	24429286	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgagccaaggctatagacgtGaagtgccccggagagtcggg	16	9	0	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:24429286G>C	uc003ned.1	-	25	2608	c.2497C>G	c.(2497-2499)CAC>GAC	p.H833D		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	833	FG-GAP 7.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						CTATAGACGTGAAGTGCCCCG	0.458													0	0	0	0.00308	0	8	48										C	24429286	G	C	24429286	3	2	107	1	0	0	0	0	1	0	0	0	6614	1290	45	1	29	1	GPLD1	6	24429286	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	6754096	24429286	146685781	51	32755										
MDC1	9656	broad.mit.edu	37	chr6	30675515	30675515	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cctccctctggctcccctctCtgtgtatctctctccaggat	6	18	4	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:30675515C>T	uc003nrg.3	-	8	3281	c.2841G>A	c.(2839-2841)CAG>CAA	p.Q947Q	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Intron	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	947				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						GCTCCCCTCTCTGTGTATCTC	0.592								Other_conserved_DNA_damage_response_genes					0	0	0	0.014323	0	24	98										T	30675515	C	T	30675515	2	4	107	1	0	0	0	0	0	0	0	1	9403	912	32	1		1	MDC1	6	30675515	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	6246229	30675515	140439552	52	32756										
COL11A2	1302	broad.mit.edu	37	chr6	33142356	33142356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gaccaggaacacccagcttgCcctgtggagggacaggaagc	14	12	0	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:33142356C>T	uc003ocx.1	-	31	2606	c.2378G>A	c.(2377-2379)GGC>GAC	p.G793D	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.G707D|COL11A2_uc003ocz.1_Missense_Mutation_p.G686D	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	793	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						ACCCAGCTTGCCCTGTGGAGG	0.617													0	0	0	0.009096	0	3	37										T	33142356	C	T	33142356	3	4	107	1	0	0	0	0	1	0	0	0	3668	753	26	2	2976	2	COL11A2	6	33142356	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	2466841	33142356	137972711	53	32757										
DNAH8	1769	broad.mit.edu	37	chr6	38854693	38854693	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgatccaccctggaggtggtCgaaatgatattccacaacgt	10	10	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:38854693C>T	uc003ooe.1	+	55	8335	c.7735C>T	c.(7735-7737)CGA>TGA	p.R2579*		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGGAGGTGGTCGAAATGATAT	0.378													0	0	0	0.007413	0	20	72										T	38854693	C	T	38854693	4	4	107	1	0	0	0	0	0	1	0	0	4607	876	31	1	7945	1	DNAH8	6	38854693	Nonsense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	5712337	38854693	132260374	54	32758										
PKHD1	5314	broad.mit.edu	37	chr6	51524597	51524597	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gggaatattggcatttacacTgctaaagacatcaacaaaac	7	8	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:51524597T>C	uc003pah.1	-	61	10603	c.10327A>G	c.(10327-10329)AGT>GGT	p.S3443G		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3443	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GCATTTACACTGCTAAAGACA	0.413													0	0	0	0.021523	0	27	101										C	51524597	T	C	51524597	3	2	107	1	0	0	0	0	1	0	0	0	11971	1580	55	5	1925	5	PKHD1	6	51524597	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	12669904	51524597	119590470	55	32759										
MANEA	79694	broad.mit.edu	37	chr6	96053848	96053848	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tcttcaaagtggttttgatgGaatttacacatattttgcca	7	6	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:96053848G>A	uc003poo.1	+	5	1096	c.956G>A	c.(955-957)GGA>GAA	p.G319E		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	319	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		GGTTTTGATGGAATTTACACA	0.338													0	0	0	0.008291	0	10	40										A	96053848	G	A	96053848	3	1	107	1	0	0	0	0	1	0	0	0	9221	1174	41	1	970	1	MANEA	6	96053848	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	44529251	96053848	75061219	56	32760										
NCOA7	135112	broad.mit.edu	37	chr6	126210736	126210736	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cgagtagaaaacacactgaaCatacatgaagatttagataa	7	6	0	5			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:126210736C>T	uc010kes.2	+	11	1985	c.1536C>T	c.(1534-1536)AAC>AAT	p.N512N	NCOA7_uc003qae.3_Silent_p.N512N|NCOA7_uc003qah.2_Silent_p.N501N|NCOA7_uc003qai.2_Silent_p.N512N|NCOA7_uc010ket.2_Silent_p.N397N	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	512				LNIHEDL->ANAHEDA: No action on the E2- induced ESR1 binding.	cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		ACACACTGAACATACATGAAG	0.388													0	0	0	0.020292	0	14	63										T	126210736	C	T	126210736	2	4	107	1	0	0	0	0	0	0	0	1	10234	477	17	2		2	NCOA7	6	126210736	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	30156888	126210736	44904331	57	32761										
CNKSR3	154043	broad.mit.edu	37	chr6	154732170	154732170	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aatggtgaatcttcgtctccGgctttcctggtccaagaagg	11	10	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr6:154732170G>C	uc003qpy.2	-	11	1682	c.1177C>G	c.(1177-1179)CGG>GGG	p.R393G		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	393	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CTTCGTCTCCGGCTTTCCTGG	0.483													0	0	0	0.016723	0	14	150										C	154732170	G	C	154732170	3	2	107	1	0	0	0	0	1	0	0	0	3608	1115	39	4	502	4	CNKSR3	6	154732170	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	28521434	154732170	16382897	58	32762										
SEMA3D	223117	broad.mit.edu	37	chr7	84651768	84651768	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	atgacatgatccaccactatCtgtgtcagtctgtaatccac	6	12	3	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr7:84651768C>T	uc003uic.2	-	11	1393	c.1353G>A	c.(1351-1353)CAG>CAA	p.Q451Q	SEMA3D_uc010led.2_Silent_p.Q451Q|SEMA3D_uc003uib.2_Silent_p.Q90Q	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	451	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CCACCACTATCTGTGTCAGTC	0.403													0	0	0	0.019004	0	34	160										T	84651768	C	T	84651768	2	4	107	1	0	0	0	0	0	0	0	1	14027	912	32	1		1	SEMA3D	7	84651768	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08		84651768	74486895	59	32763										
MEPCE	56257	broad.mit.edu	37	chr7	100028509	100028509	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ccgtgccgcccacagcccctCtcacccccttactccacggg	7	23	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr7:100028509C>A	uc003uuw.2	+	1	981	c.868C>A	c.(868-870)CTC>ATC	p.L290I	ZCWPW1_uc003uut.2_5'Flank|ZCWPW1_uc011kjr.1_5'Flank|ZCWPW1_uc003uuu.1_5'Flank|ZCWPW1_uc011kjt.1_5'Flank|ZCWPW1_uc011kju.1_5'Flank|MEPCE_uc003uuv.2_5'UTR	NM_019606	NP_062552	Q7L2J0	MEPCE_HUMAN	bin3, bicoid-interacting 3	290							methyltransferase activity			upper_aerodigestive_tract(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACAGCCCCTCTCACCCCCTT	0.667													1	0	4.34311e-12	0.015359	4.60369e-12	36	102										A	100028509	C	A	100028509	3	1	107	1	0	0	0	0	1	0	0	0	9477	913	32	3	870	3	MEPCE	7	100028509	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	15376741	100028509	59110154	60	32764										
DOCK4	9732	broad.mit.edu	37	chr7	111580178	111580178	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttcttacatgtatactttcaGaatgaggtcatcctttgtct	6	8	4	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr7:111580178G>A	uc003vfx.2	-	11	1233	c.964C>T	c.(964-966)CTG>TTG	p.L322L	DOCK4_uc003vfy.2_Silent_p.L322L|DOCK4_uc003vga.1_5'UTR|DOCK4_uc010ljt.1_Silent_p.L322L	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	322					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TATACTTTCAGAATGAGGTCA	0.493													0	0	0	0.013537	0	12	67										A	111580178	G	A	111580178	2	1	107	1	0	0	0	0	0	0	0	1	4689	933	33	1		1	DOCK4	7	111580178	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	11551669	111580178	47558485	61	32765										
CREB3L2	64764	broad.mit.edu	37	chr7	137590506	137590506	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tctcctctgattttgacaggGgcaatttggtggggatggga	15	6	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr7:137590506G>A	uc003vtw.2	-	6	1252	c.857C>T	c.(856-858)CCC>CTC	p.P286L	CREB3L2_uc003vtx.1_Missense_Mutation_p.P286L|CREB3L2_uc003vtv.2_Missense_Mutation_p.P223L	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like	286	Cytoplasmic (Potential).				chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						TTTTGACAGGGGCAATTTGGT	0.522			T	FUS	fibromyxoid sarcoma								0	0	0	0.015359	0	34	161										A	137590506	G	A	137590506	3	1	107	1	0	0	0	0	1	0	0	0	3857	1232	43	2	733	2	CREB3L2	7	137590506	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	26010328	137590506	21548157	62	32766										
VIPR2	7434	broad.mit.edu	37	chr7	158935195	158935195	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	acattttgtttcttcctcctGtatttccagatgaaatcggc	6	10	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr7:158935195G>A	uc003woh.2	-	2	280	c.94C>T	c.(94-96)CAG>TAG	p.Q32*	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	32	Extracellular (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		TCTTCCTCCTGTATTTCCAGA	0.398													0	0	0	0.021523	0	23	99										A	158935195	G	A	158935195	4	1	107	1	0	0	0	0	0	1	0	0	17167	1386	48	2	1270	2	VIPR2	7	158935195	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	21344689	158935195	203468	63	32767										
MTUS1	57509	broad.mit.edu	37	chr8	17611479	17611479	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aactggctttgtcaacatctTcctgattcgatttcacggca	7	11	3	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr8:17611479T>G	uc003wxv.2	-	2	2312	c.1838A>C	c.(1837-1839)GAA>GCA	p.E613A	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.E613A|MTUS1_uc010lsz.2_Missense_Mutation_p.E613A	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	613						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GTCAACATCTTCCTGATTCGA	0.428													0	0	0	0.015359	0	33	125										G	17611479	T	G	17611479	3	3	107	1	0	0	0	0	1	0	0	0	9965	1783	62	5	2349	5	MTUS1	8	17611479	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08		17611479	128752543	64	32768										
PREX2	80243	broad.mit.edu	37	chr8	68956794	68956794	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggccggatcaacacggaggtGatggaagtggagaatgtgga	18	5	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr8:68956794G>C	uc003xxv.1	+	8	939	c.912G>C	c.(910-912)GTG>GTC	p.V304V	PREX2_uc003xxu.1_Silent_p.V304V|PREX2_uc011lez.1_Silent_p.V239V	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	304	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACACGGAGGTGATGGAAGTGG	0.413													0	0	0	0.024245	0	13	120										C	68956794	G	C	68956794	2	2	107	1	0	0	0	0	0	0	0	1	12477	1277	45	1		1	PREX2	8	68956794	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	51345315	68956794	77407228	65	32769										
FAM164A	51101	broad.mit.edu	37	chr8	79609675	79609675	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cacttaaaaagtcaaattctCctggaactgcatcatcagga	6	10	4	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr8:79609675C>G	uc003ybd.2	+	6	640	c.538C>G	c.(538-540)CCT>GCT	p.P180A		NM_016010	NP_057094	Q96GY0	F164A_HUMAN	hypothetical protein LOC51101	180										ovary(1)	1						GTCAAATTCTCCTGGAACTGC	0.368													0	0	0	0.006214	0	9	55										G	79609675	C	G	79609675	3	3	107	1	0	0	0	0	1	0	0	0	5478	855	30	1	560	1	FAM164A	8	79609675	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	10652881	79609675	66754347	66	32770										
CNBD1	168975	broad.mit.edu	37	chr8	88218312	88218312	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttcagctaaatgataagcatCtgaaaacacttagtaagact	6	7	2	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr8:88218312C>T	uc003ydy.2	+	5	571	c.523C>T	c.(523-525)CTG>TTG	p.L175L		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	175										ovary(3)	3						TGATAAGCATCTGAAAACACT	0.398													0	0	0	0.014758	0	5	30										T	88218312	C	T	88218312	2	4	107	1	0	0	0	0	0	0	0	1	3591	912	32	1		1	CNBD1	8	88218312	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	8608637	88218312	58145710	67	32771										
ATAD2	29028	broad.mit.edu	37	chr8	124383508	124383508	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	attaaacactcccaagtcttCaagttctctcattcgctgtc	4	13	4	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr8:124383508C>G	uc003yqh.3	-	5	715	c.607G>C	c.(607-609)GAA>CAA	p.E203Q	ATAD2_uc011lii.1_5'UTR|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E203Q	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CCCAAGTCTTCAAGTTCTCTC	0.308													0	0	0	0.004482	0	8	28										G	124383508	C	G	124383508	3	3	107	1	0	0	0	0	1	0	0	0	1071	835	29	1	3661	1	ATAD2	8	124383508	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	36165196	124383508	21980514	68	32772										
SCRIB	23513	broad.mit.edu	37	chr8	144886946	144886946	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgggggaggcagcggtcagcAgggagacggcgtggtcatgc	21	8	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr8:144886946A>T	uc003yzp.1	-	21	2808	c.2801T>A	c.(2800-2802)CTG>CAG	p.L934Q	SCRIB_uc003yzn.1_5'Flank|SCRIB_uc003yzo.1_Missense_Mutation_p.L934Q	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	934	PDZ 2.|Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGCGGTCAGCAGGGAGACGGC	0.602													0	0	0	0.014758	0	4	22										T	144886946	A	T	144886946	3	4	107	1	0	0	0	0	1	0	0	0	13937	188	7	5	2234	5	SCRIB	8	144886946	Missense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	20503438	144886946	1477076	69	32773										
DOCK8	81704	broad.mit.edu	37	chr9	336580	336580	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtgacaattgtttttcttaaAgggagaagctcagtgggtga	13	4	2	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr9:336580A>T	uc003zgf.2	+	12	1398	c.1286_splice	c.e12-2	p.G429_splice	DOCK8_uc011lls.1_Splice_Site_p.G429_splice|DOCK8_uc010mgu.2_Splice_Site|DOCK8_uc010mgv.2_Splice_Site_p.G361_splice|DOCK8_uc003zgg.2_Splice_Site_p.G361_splice|DOCK8_uc003zgh.2_Splice_Site	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TTTTTCTTAAAGGGAGAAGCT	0.423													0	0	0	0.013537	0	13	51										T	336580	A	T	336580	5	4	107	1	0	0	0	0	0	0	1	0	4693	86	3	5	1330	5	DOCK8	9	336580	Splice_Site	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08		336580	140876851	70	32774										
RFX3	5991	broad.mit.edu	37	chr9	3330299	3330299	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttgtgtgtgtcactgagtgaCcagaattctccattgagttg	11	7	2	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr9:3330299C>T	uc003zhr.2	-	5	746	c.434G>A	c.(433-435)GGT>GAT	p.G145D	RFX3_uc010mhd.2_Missense_Mutation_p.G145D|RFX3_uc003zhs.1_Missense_Mutation_p.G145D|RFX3_uc003zht.1_Missense_Mutation_p.G145D|RFX3_uc010mhe.1_Missense_Mutation_p.G145D	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	145					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CACTGAGTGACCAGAATTCTC	0.458													0	0	0	0.00308	0	7	63										T	3330299	C	T	3330299	3	4	107	1	0	0	0	0	1	0	0	0	13264	507	18	2	2027	2	RFX3	9	3330299	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	2993719	3330299	137883132	71	32775										
TBC1D2	55357	broad.mit.edu	37	chr9	100991351	100991351	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aagaatgggaaggtgttgttCtggcgcttggctttctgagc	15	6	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr9:100991351C>G	uc011lvb.1	-	5	1041	c.861G>C	c.(859-861)CAG>CAC	p.Q287H	TBC1D2_uc004ayq.2_Missense_Mutation_p.Q287H|TBC1D2_uc004ayr.2_Missense_Mutation_p.Q69H|TBC1D2_uc004ayo.3_Missense_Mutation_p.Q287H	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	287						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AGGTGTTGTTCTGGCGCTTGG	0.532													0	0	0	0.016723	0	14	89										G	100991351	C	G	100991351	3	3	107	1	0	0	0	0	1	0	0	0	15605	912	32	1	1928	1	TBC1D2	9	100991351	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	97661052	100991351	40222080	72	32776										
GOLGA1	2800	broad.mit.edu	37	chr9	127642825	127642825	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ccctctaggaccatggtatcCgagggtttgagatagacggc	13	10	1	2	rs146171341	by1000genomes	TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr9:127642825C>T	uc004bpc.2	-	23	2630	c.2288G>A	c.(2287-2289)CGG>CAG	p.R763Q	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	763						Golgi cisterna membrane				ovary(1)	1						CCATGGTATCCGAGGGTTTGA	0.502													0	0	0	0.01892	0	23	169										T	127642825	C	T	127642825	3	4	107	1	0	0	0	0	1	0	0	0	6551	652	23	2	19	2	GOLGA1	9	127642825	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	26651474	127642825	13570606	73	32777										
NUP188	23511	broad.mit.edu	37	chr9	131760889	131760889	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctctgctgcttatcctcctcCggcagtggaagaggtgaggc	13	12	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr9:131760889C>T	uc004bws.1	+	32	3524	c.3502C>T	c.(3502-3504)CGG>TGG	p.R1168W	NUP188_uc004bwu.2_Missense_Mutation_p.R511W	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1168					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TATCCTCCTCCGGCAGTGGAA	0.567													0	0	0	0.028581	0	14	90										T	131760889	C	T	131760889	3	4	107	1	0	0	0	0	1	0	0	0	10758	643	23	2	3628	2	NUP188	9	131760889	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	4118064	131760889	9452542	74	32778										
MAMDC4	158056	broad.mit.edu	37	chr9	139754396	139754396	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggcagtgccctcctattgctCatgctcctggtgctgctggg	13	13	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr9:139754396C>G	uc004cjs.2	+	26	3302	c.3252C>G	c.(3250-3252)CTC>CTG	p.L1084L	MAMDC4_uc011mej.1_Silent_p.L421L	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1163	Helical; (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TCCTATTGCTCATGCTCCTGG	0.647													0	0	0	0.006122	0	16	32										G	139754396	C	G	139754396	2	3	107	1	0	0	0	0	0	0	0	1	9204	813	29	1		1	MAMDC4	9	139754396	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	7993507	139754396	1459035	75	32779										
GPR158	57512	broad.mit.edu	37	chr10	25885648	25885648	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgagctagacatgggccgatCtggatcctacctgaacagca	11	11	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr10:25885648C>G	uc001isj.2	+	10	2135	c.2075C>G	c.(2074-2076)TCT>TGT	p.S692C	GPR158_uc001isk.2_Missense_Mutation_p.S67C	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	692	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ATGGGCCGATCTGGATCCTAC	0.443													0	0	0	0.020292	0	14	42										G	25885648	C	G	25885648	3	3	107	1	0	0	0	0	1	0	0	0	6663	913	32	1	2113	1	GPR158	10	25885648	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08		25885648	109649099	76	32780										
MKX	283078	broad.mit.edu	37	chr10	28032225	28032225	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tcgggaatgcccacctcgggGcgggcgtgaggactgtccag	17	12	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr10:28032225G>A	uc001ity.3	-	2	345	c.120C>T	c.(118-120)CGC>CGT	p.R40R	MKX_uc001itx.3_Silent_p.R40R	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	40					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCACCTCGGGGCGGGCGTGAG	0.726													0	0	0	0.008291	0	10	33										A	28032225	G	A	28032225	2	1	107	1	0	0	0	0	0	0	0	1	9610	1190	42	2		2	MKX	10	28032225	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	2146577	28032225	107502522	77	32781										
HKDC1	80201	broad.mit.edu	37	chr10	71002944	71002944	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gatccctggttcaggaactgGcaccaatgcgtgttacatgg	12	10	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr10:71002944G>A	uc001jpf.3	+	7	831	c.698G>A	c.(697-699)GGC>GAC	p.G233D	HKDC1_uc010qje.1_Missense_Mutation_p.G96D	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	233					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						TCAGGAACTGGCACCAATGCG	0.562													0	0	0	0.014323	0	21	114										A	71002944	G	A	71002944	3	1	107	1	0	0	0	0	1	0	0	0	7193	1203	42	2	724	2	HKDC1	10	71002944	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	42970719	71002944	64531803	78	32782										
PRF1	5551	broad.mit.edu	37	chr10	72358594	72358594	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cgagtggcgctcccggtaggTttggtggaaggaggccgtca	18	9	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr10:72358594T>C	uc009xqg.2	-	3	1044	c.883A>G	c.(883-885)ACC>GCC	p.T295A	PRF1_uc001jrf.3_Missense_Mutation_p.T295A	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	295	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCCCGGTAGGTTTGGTGGAAG	0.607			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.021523	0	27	73										C	72358594	T	C	72358594	3	2	107	1	0	0	0	0	1	0	0	0	12478	1725	60	5	788	5	PRF1	10	72358594	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	1355650	72358594	63176153	79	32783										
TACC2	10579	broad.mit.edu	37	chr10	123846852	123846852	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gcgacagtccacatggagaaGatggtcccggggactttgct	14	10	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr10:123846852G>T	uc001lfv.2	+	4	5197	c.4837G>T	c.(4837-4839)GAT>TAT	p.D1613Y	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.D1613Y|TACC2_uc010qtv.1_Missense_Mutation_p.D1613Y	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1613						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACATGGAGAAGATGGTCCCGG	0.582													1	0	4.35082e-09	0.010504	4.52144e-09	22	69										T	123846852	G	T	123846852	3	4	107	1	0	0	0	0	1	0	0	0	15499	942	33	3	4847	3	TACC2	10	123846852	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	51488258	123846852	11687895	80	32784										
MRPL23	6150	broad.mit.edu	37	chr11	1977518	1977518	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	accttcacgttcccagatctGtttcccgagaaagacgagag	9	12	2	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:1977518G>A	uc001lux.2	+	5	421	c.330G>A	c.(328-330)CTG>CTA	p.L110L		NM_021134	NP_066957	Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	110					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|ovary(1)	3		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		TCCCAGATCTGTTTCCCGAGA	0.622													0	0	0	0.01892	0	24	167										A	1977518	G	A	1977518	2	1	107	1	0	0	0	0	0	0	0	1	9789	1364	48	2		2	MRPL23	11	1977518	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		1977518	133028998	81	32785										
TRIM5	85363	broad.mit.edu	37	chr11	5686559	5686559	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttatctgtggtttcggagagCtcacttgtctcttatcttca	8	9	5	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:5686559C>T	uc001mbm.1	-	8	1219	c.962G>A	c.(961-963)AGC>AAC	p.S321N	TRIM78P_uc009yer.2_RNA|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Intron|TRIM5_uc001mbo.2_Intron|TRIM5_uc001mbp.2_3'UTR	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	321	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		TTTCGGAGAGCTCACTTGTCT	0.408													0	0	0	0.020292	0	13	69										T	5686559	C	T	5686559	3	4	107	1	0	0	0	0	1	0	0	0	16522	797	28	2	613	2	TRIM5	11	5686559	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	3709041	5686559	129319957	82	32786										
STK33	65975	broad.mit.edu	37	chr11	8483449	8483449	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	caagtaacttcacagcagagCttccagccttaatcaatgaa	6	11	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:8483449C>A	uc001mgi.1	-	4	1380	c.461G>T	c.(460-462)AGC>ATC	p.S154I	STK33_uc001mgj.1_Missense_Mutation_p.S154I|STK33_uc001mgk.1_Missense_Mutation_p.S154I|STK33_uc010rbn.1_Missense_Mutation_p.S113I|STK33_uc001mgl.3_5'UTR|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	154	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		CACAGCAGAGCTTCCAGCCTT	0.338													1	0	4.84862e-15	0.010729	5.2178e-15	11	39										A	8483449	C	A	8483449	3	1	107	1	0	0	0	0	1	0	0	0	15299	797	28	4	1119	4	STK33	11	8483449	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	2796890	8483449	126523067	83	32787										
AMPD3	272	broad.mit.edu	37	chr11	10514903	10514903	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cgctgtgttccaggtggacaCacacatccatgcggccgcct	11	15	0	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:10514903C>T	uc001mio.1	+	7	1282	c.947C>T	c.(946-948)ACA>ATA	p.T316I	AMPD3_uc010rbz.1_Missense_Mutation_p.T157I|AMPD3_uc001min.1_Missense_Mutation_p.T325I|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Missense_Mutation_p.T323I|AMPD3_uc009yfy.2_Missense_Mutation_p.T316I	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	316					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CAGGTGGACACACACATCCAT	0.577													0	0	0	0.009718	0	44	160										T	10514903	C	T	10514903	3	4	107	1	0	0	0	0	1	0	0	0	587	478	17	2	1020	2	AMPD3	11	10514903	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	2031454	10514903	124491613	84	32788										
PAMR1	25891	broad.mit.edu	37	chr11	35454248	35454248	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cttgaagccagggctcctcaCgtctgccaggacattccagc	10	15	2	1	rs148541461		TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:35454248C>T	uc001mwg.2	-	11	1862	c.1819G>A	c.(1819-1821)GTG>ATG	p.V607M	PAMR1_uc001mwf.2_Missense_Mutation_p.V624M|PAMR1_uc010rew.1_Missense_Mutation_p.V496M|PAMR1_uc010rex.1_Missense_Mutation_p.V567M	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	607	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GGGCTCCTCACGTCTGCCAGG	0.617													0	0	0	0.008291	0	10	56										T	35454248	C	T	35454248	3	4	107	1	0	0	0	0	1	0	0	0	11413	536	19	2	347	2	PAMR1	11	35454248	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	24939345	35454248	99552268	85	32789										
SPRYD5	84767	broad.mit.edu	37	chr11	55653304	55653304	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtcccattgagtgggctgctGaggaacgccgggtaagtgat	16	8	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:55653304G>T	uc010rip.1	+	2	492	c.400G>T	c.(400-402)GAG>TAG	p.E134*	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	134						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GTGGGCTGCTGAGGAACGCCG	0.478													1	0	2.0095e-06	0.001984	2.06803e-06	7	36										T	55653304	G	T	55653304	4	4	107	1	0	0	0	0	0	1	0	0	15110	1291	45	3	402	3	SPRYD5	11	55653304	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	20199056	55653304	79353212	86	32790										
C11orf80	79703	broad.mit.edu	37	chr11	66605889	66605889	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agggcactgaggacgcacctGataacagcagcctggagctc	13	12	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:66605889G>A	uc001ojf.2	+	15	1727	c.1720G>A	c.(1720-1722)GAT>AAT	p.D574N	C11orf80_uc001ojg.2_Missense_Mutation_p.D341N|C11orf80_uc001ojh.2_Missense_Mutation_p.D342N|C11orf80_uc001oji.2_Missense_Mutation_p.D342N|C11orf80_uc010rpl.1_Missense_Mutation_p.D208N|C11orf80_uc001ojj.2_Missense_Mutation_p.D172N	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	419											0						GGACGCACCTGATAACAGCAG	0.443													0	0	0	0.008291	0	11	58										A	66605889	G	A	66605889	3	1	107	1	0	0	0	0	1	0	0	0	1664	1290	45	1	1778	1	C11orf80	11	66605889	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	10952585	66605889	68400627	87	32791										
ACY3	91703	broad.mit.edu	37	chr11	67414351	67414351	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggcagccggatgtggctgccGggttggccagcacaggcaca	17	12	0	0	rs145934175		TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:67414351G>C	uc001omq.2	-	3	335	c.164C>G	c.(163-165)CCG>CGG	p.P55R		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	55					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TGTGGCTGCCGGGTTGGCCAG	0.662													0	0	0	0.004482	0	8	24										C	67414351	G	C	67414351	3	2	107	1	0	0	0	0	1	0	0	0	227	1116	39	4	819	4	ACY3	11	67414351	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	808462	67414351	67592165	88	32792										
ODZ4	26011	broad.mit.edu	37	chr11	78399233	78399233	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aactgctcacctggccagtaGggaaggtcacatttgtcagg	12	10	3	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:78399233G>T	uc001ozl.3	-	29	5589	c.5126C>A	c.(5125-5127)CCT>CAT	p.P1709H	ODZ4_uc009yvb.1_Missense_Mutation_p.P293H	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1709	YD 4.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CTGGCCAGTAGGGAAGGTCAC	0.507													1	0	2.81731e-10	0.010818	2.9715e-10	31	182										T	78399233	G	T	78399233	3	4	107	1	0	0	0	0	1	0	0	0	10837	1000	35	4	3207	4	ODZ4	11	78399233	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	10984882	78399233	56607283	89	32793										
SIK2	23235	broad.mit.edu	37	chr11	111558772	111558772	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	atgagtctgaagccaggcgaAaattctggcaaatcctgtct	10	9	3	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:111558772A>T	uc001plt.2	+	4	482	c.364A>T	c.(364-366)AAA>TAA	p.K122*		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	122	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						AGCCAGGCGAAAATTCTGGCA	0.403													0	0	0	0.020292	0	13	56										T	111558772	A	T	111558772	4	4	107	1	0	0	0	0	0	1	0	0	14318	15	1	5	378	5	SIK2	11	111558772	Nonsense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	33159539	111558772	23447744	90	32794										
MLL	4297	broad.mit.edu	37	chr11	118382708	118382708	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	taaagtccaggaagctcgatCaaatgcccgcctaaagcagc	9	12	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:118382708C>G	uc001pta.2	+	31	11128	c.11105C>G	c.(11104-11106)TCA>TGA	p.S3702*	MLL_uc001ptb.2_Nonsense_Mutation_p.S3705*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3702	FYR C-terminal.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAAGCTCGATCAAATGCCCGC	0.428			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.001984	0	7	38										G	118382708	C	G	118382708	4	3	107	1	0	0	0	0	0	1	0	0	9620	838	29	1	11227	1	MLL	11	118382708	Nonsense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	6823936	118382708	16623808	91	32795										
OR8D1	283159	broad.mit.edu	37	chr11	124179947	124179947	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgagatgagagctgcatgttCcaaaagctttggaccggccc	12	10	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:124179947C>T	uc010sag.1	-	1	716	c.716G>A	c.(715-717)GGA>GAA	p.G239E		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GCTGCATGTTCCAAAAGCTTT	0.517													0	0	0	0.028581	0	17	57										T	124179947	C	T	124179947	3	4	107	1	0	0	0	0	1	0	0	0	11231	855	30	1	213	1	OR8D1	11	124179947	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	5797239	124179947	10826569	92	32796										
OR8B2	26595	broad.mit.edu	37	chr11	124252654	124252654	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aacaatgagaacaaccacctCgttgacataggtgctggtgc	10	10	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:124252654C>T	uc010sai.1	-	1	586	c.586G>A	c.(586-588)GAG>AAG	p.E196K		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ACAACCACCTCGTTGACATAG	0.433													0	0	0	0.007413	0	18	83										T	124252654	C	T	124252654	3	4	107	1	0	0	0	0	1	0	0	0	11227	893	31	1	358	1	OR8B2	11	124252654	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	72707	124252654	10753862	93	32797										
ARHGAP32	9743	broad.mit.edu	37	chr11	128840032	128840032	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggaaggcggtgaaggggtctCaactggactgtgccataggc	17	8	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr11:128840032C>T	uc009zcp.2	-	22	5034	c.5034G>A	c.(5032-5034)TTG>TTA	p.L1678L	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Silent_p.L637L|ARHGAP32_uc001qez.2_Silent_p.L1329L	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1678	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GAAGGGGTCTCAACTGGACTG	0.512													0	0	0	0.014323	0	23	103										T	128840032	C	T	128840032	2	4	107	1	0	0	0	0	0	0	0	1	881	825	29	1		1	ARHGAP32	11	128840032	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	4587378	128840032	6166484	94	32798										
CD69	969	broad.mit.edu	37	chr12	9913402	9913402	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctgttctctgctacgaaacaAttttcagagctcatctttat	5	10	4	1	rs149884332	by1000genomes	TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:9913402A>G	uc001qwk.2	-	1	96	c.15T>C	c.(13-15)AAT>AAC	p.N5N	CD69_uc010sgu.1_Silent_p.N5N|CD69_uc010sgv.1_Silent_p.N5N	NM_001781	NP_001772	Q07108	CD69_HUMAN	CD69 molecule	5	Cytoplasmic (Potential).					integral to plasma membrane	sugar binding|transmembrane receptor activity				0						CTACGAAACAATTTTCAGAGC	0.408													0	0	0	0.024245	0	14	88										G	9913402	A	G	9913402	2	3	107	1	0	0	0	0	0	0	0	1	3031	98	4	5		5	CD69	12	9913402	Silent	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08		9913402	123938493	95	32799										
CPNE8	144402	broad.mit.edu	37	chr12	39047685	39047685	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttagcatttcagagcacagtCatatttgagtctgtaacaca	7	8	3	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:39047685C>T	uc001rls.1	-	20	1778	c.1694G>A	c.(1693-1695)TGA>TAA	p.*565*	CPNE8_uc001rlr.1_Silent_p.*224*	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	565										pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				AGAGCACAGTCATATTTGAGT	0.458													0	0	0	0.001984	0	7	30										T	39047685	C	T	39047685	2	4	107	1	0	0	0	0	0	0	0	1	3818	837	29	1		1	CPNE8	12	39047685	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	29134283	39047685	94804210	96	32800										
ARID2	196528	broad.mit.edu	37	chr12	46125015	46125015	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	accaggtttctgagaagaatCagtggggagaaattgttgaa	13	4	2	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:46125015C>T	uc001ros.1	+	3	202	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q68*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	68	ARID.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TGAGAAGAATCAGTGGGGAGA	0.378													0	0	0	0.028581	0	16	64										T	46125015	C	T	46125015	4	4	107	1	0	0	0	0	0	1	0	0	915	827	29	1	212	1	ARID2	12	46125015	Nonsense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	7077330	46125015	87726880	97	32801										
H1FNT	341567	broad.mit.edu	37	chr12	48723522	48723522	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctccctggaggaccccagccGcgccccggagctcccggagg	14	19	0	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:48723522G>A	uc001rrm.2	+	1	760	c.448G>A	c.(448-450)GCG>ACG	p.A150T		NM_181788	NP_861453	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	150	Arg-rich.				chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			pancreas(1)	1						GACCCCAGCCGCGCCCCGGAG	0.706													0	0	0	0.001984	0	7	24										A	48723522	G	A	48723522	3	1	107	1	0	0	0	0	1	0	0	0	6921	1087	38	2	450	2	H1FNT	12	48723522	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	2598507	48723522	85128373	98	32802										
MLL2	8085	broad.mit.edu	37	chr12	49444142	49444142	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gcattcaggttctgaaacttTctcagtctccatctcgtgca	7	12	5	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:49444142T>A	uc001rta.3	-	11	3229	c.3229A>T	c.(3229-3231)AAA>TAA	p.K1077*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1077	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCTGAAACTTTCTCAGTCTCC	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.014758	0	5	24										A	49444142	T	A	49444142	4	1	107	1	0	0	0	0	0	1	0	0	9621	1792	62	5	13560	5	MLL2	12	49444142	Nonsense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	720620	49444142	84407753	99	32803										
SILV	6490	broad.mit.edu	37	chr12	56349288	56349288	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctgaccactgccaggctgttGgtatcagccagagacacatt	10	12	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:56349288G>C	uc001sip.2	-	9	1753	c.1722C>G	c.(1720-1722)ACC>ACG	p.T574T	SILV_uc001siq.2_Silent_p.T574T|SILV_uc010spx.1_Silent_p.T488T|SILV_uc001sir.2_Silent_p.T574T	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	574	Lumenal (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						CCAGGCTGTTGGTATCAGCCA	0.582													0	0	0	0.024245	0	16	73										C	56349288	G	C	56349288	2	2	107	1	0	0	0	0	0	0	0	1	14322	1335	47	4		4	SILV	12	56349288	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	6905146	56349288	77502607	100	32804										
ANKRD52	283373	broad.mit.edu	37	chr12	56647181	56647181	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tttgtcggcacaatcaatctCgctgcctgtgaggggatgca	12	10	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:56647181C>T	uc001skm.3	-	10	1081	c.991G>A	c.(991-993)GAG>AAG	p.E331K		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	331	ANK 10.						protein binding			ovary(2)	2						CAATCAATCTCGCTGCCTGTG	0.532													0	0	0	0.006122	0	17	72										T	56647181	C	T	56647181	3	4	107	1	0	0	0	0	1	0	0	0	678	893	31	1	2315	1	ANKRD52	12	56647181	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	297893	56647181	77204714	101	32805										
BEST3	144453	broad.mit.edu	37	chr12	70070717	70070717	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttaagccatcctgcatagaaGaagaattgtaggagggtgaa	12	5	0	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:70070717G>A	uc001svg.2	-	7	1073	c.846C>T	c.(844-846)TTC>TTT	p.F282F	BEST3_uc001svd.1_Silent_p.F282F|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Intron|BEST3_uc010stm.1_Silent_p.F176F|BEST3_uc001svh.2_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	282	Helical; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CTGCATAGAAGAAGAATTGTA	0.473													0	0	0	0.00632	0	28	147										A	70070717	G	A	70070717	2	1	107	1	0	0	0	0	0	0	0	1	1406	933	33	1		1	BEST3	12	70070717	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	13423536	70070717	63781178	102	32806										
NDUFA12	55967	broad.mit.edu	37	chr12	95397387	95397387	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctacctgaaaaaaacccgtaGatagcctcggagaccgccgt	9	13	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:95397387G>T	uc001tdl.2	-	1	125	c.70C>A	c.(70-72)CTA>ATA	p.L24I		NM_018838	NP_061326	Q9UI09	NDUAC_HUMAN	13kDa differentiation-associated protein	24					respiratory electron transport chain|respiratory gaseous exchange|response to oxidative stress|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	AAAACCCGTAGATAGCCTCGG	0.637													1	0	5.91797e-21	0.012213	6.43389e-21	30	168										T	95397387	G	T	95397387	3	4	107	1	0	0	0	0	1	0	0	0	10262	933	33	3	383	3	NDUFA12	12	95397387	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	25326670	95397387	38454508	103	32807										
C12orf63	374467	broad.mit.edu	37	chr12	97159026	97159026	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gatgtctacatattatgcaaAaaaactgatatatgtaatat	5	4	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:97159026A>G	uc001tet.1	+	27	3664	c.3586A>G	c.(3586-3588)AAA>GAA	p.K1196E		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1196										skin(6)|ovary(1)	7						TATTATGCAAAAAAACTGATA	0.343													0	0	0	0.014758	0	5	27										G	97159026	A	G	97159026	3	3	107	1	0	0	0	0	1	0	0	0	1706	15	1	5	3688	5	C12orf63	12	97159026	Missense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	1761639	97159026	36692869	104	32808										
ANO4	121601	broad.mit.edu	37	chr12	101333128	101333128	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	atattctttttgatgaattaGaagctgtcagcagtccttgc	8	7	2	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:101333128G>A	uc010svm.1	+	4	768	c.196G>A	c.(196-198)GAA>AAA	p.E66K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.E31K|ANO4_uc001thx.2_Missense_Mutation_p.E66K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	66	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TGATGAATTAGAAGCTGTCAG	0.413										HNSCC(74;0.22)			0	0	0	0.024334	0	26	74										A	101333128	G	A	101333128	3	1	107	1	0	0	0	0	1	0	0	0	699	943	33	1	97	1	ANO4	12	101333128	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	4174102	101333128	32518767	105	32809										
DTX1	1840	broad.mit.edu	37	chr12	113532886	113532886	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ccacctgcaaggccatctacGgggagaagacgggtacgcag	14	12	1	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:113532886G>A	uc001tuk.1	+	7	1762	c.1426G>A	c.(1426-1428)GGG>AGG	p.G476R		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	476					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						GGCCATCTACGGGGAGAAGAC	0.652													0	0	0	0.016723	0	14	82										A	113532886	G	A	113532886	3	1	107	1	0	0	0	0	1	0	0	0	4793	1116	39	2	1452	2	DTX1	12	113532886	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	12199758	113532886	20319009	106	32810										
LRRC43	254050	broad.mit.edu	37	chr12	122670812	122670812	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgagcgccaatcgaatcaagGaggtggatgccaccaatctg	12	10	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr12:122670812G>A	uc009zxm.2	+	3	512	c.487G>A	c.(487-489)GAG>AAG	p.E163K	LRRC43_uc001ubw.3_5'UTR|LRRC43_uc009zxl.1_RNA	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	163	LRR 1.										0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		TCGAATCAAGGAGGTGGATGC	0.562													0	0	0	0.004672	0	3	11										A	122670812	G	A	122670812	3	1	107	1	0	0	0	0	1	0	0	0	9001	1175	41	1	497	1	LRRC43	12	122670812	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	9137926	122670812	11181083	107	32811										
KLF5	688	broad.mit.edu	37	chr13	73636680	73636683	+	Frame_Shift_Del	DEL	CAAG	CAAG	-													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcctggaagtccagatagaCaagcagagatgctccagaat							TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			CAAG	-	CAAG	CAAG		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr13:73636680_73636683delCAAG	uc001vje.2	+	2	1267_1270	c.943_946delCAAG	c.(943-948)CAAGCAfs	p.Q315fs	KLF5_uc001vjd.2_Frame_Shift_Del_p.Q224fs	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	315_316					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TCCAGATAGACAAGCAGAGATGCT	0.495																		19	142	---	---								-	73636683	CAAG	-	73636680	7	5	107	1	0	1	0	1	0	0	0	0	8349	479	17	0	949	0	KLF5	13	73636680	Frame_Shift_Del	DEL	CAAG	TCGA-GC-A3WC-01A-31D-A22Z-08		73636680	41533198	108	32812										
POU4F1	5457	broad.mit.edu	37	chr13	79176005	79176005	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gaagcgctccgcgaacgcctCgagctcgcgcgggtccgtgt	15	15	0	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr13:79176005C>G	uc001vkv.2	-	2	1039	c.805G>C	c.(805-807)GAG>CAG	p.E269Q	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	269	POU-specific.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GCGAACGCCTCGAGCTCGCGC	0.587													0	0	0	0.014758	0	5	23										G	79176005	C	G	79176005	3	3	107	1	0	0	0	0	1	0	0	0	12278	893	31	1	458	1	POU4F1	13	79176005	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	5539325	79176005	35993873	109	32813										
RAB20	55647	broad.mit.edu	37	chr13	111176499	111176499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aggtgaggatgatggcggccGccccccggcagtacatggag	17	11	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr13:111176499G>A	uc001vqy.2	-	2	423	c.218C>T	c.(217-219)GCG>GTG	p.A73V		NM_017817	NP_060287	Q9NX57	RAB20_HUMAN	RAB20, member RAS oncogene family	73					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	all_cancers(4;1.54e-11)|all_epithelial(4;1.22e-06)|all_lung(23;1e-05)|Lung NSC(43;0.000453)|Colorectal(4;0.00323)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.197)			GATGGCGGCCGCCCCCCGGCA	0.607													0	0	0	0.008361	0	29	81										A	111176499	G	A	111176499	3	1	107	1	0	0	0	0	1	0	0	0	12907	1087	38	2	490	2	RAB20	13	111176499	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	32000494	111176499	3993379	110	32814										
OR4M1	441670	broad.mit.edu	37	chr14	20248931	20248931	+	Frame_Shift_Del	DEL	G	G	-													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctggtggctctctcctggatGgggggcttcattcattctat							TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:20248931delG	uc010tku.1	+	1	450	c.450delG	c.(448-450)ATGfs	p.M150fs		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTCCTGGATGGGGGGCTTCA	0.502																		7	582	---	---								-	20248931	G	-	20248931	7	5	107	1	0	1	0	1	0	0	0	0	11075	1348	47	0	452	0	OR4M1	14	20248931	Frame_Shift_Del	DEL	G	TCGA-GC-A3WC-01A-31D-A22Z-08		20248931	87100609	111	32815										
NDRG2	57447	broad.mit.edu	37	chr14	21486650	21486650	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tctgggtggggtccagttttGagttacattccacctggagt	13	8	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:21486650G>C	uc001vyy.2	-	14	977	c.827C>G	c.(826-828)TCA>TGA	p.S276*	NDRG2_uc010tll.1_Nonsense_Mutation_p.S272*|NDRG2_uc001vyt.2_Nonsense_Mutation_p.S189*|NDRG2_uc001vyu.2_Nonsense_Mutation_p.S233*|NDRG2_uc001vyv.2_Nonsense_Mutation_p.S262*|NDRG2_uc001vyw.2_Nonsense_Mutation_p.S262*|NDRG2_uc001vzb.2_Nonsense_Mutation_p.S216*|NDRG2_uc001vyx.2_Nonsense_Mutation_p.S276*|NDRG2_uc001vza.2_Nonsense_Mutation_p.S262*|NDRG2_uc001vyz.2_Nonsense_Mutation_p.S262*|NDRG2_uc001vzc.2_Intron|NDRG2_uc001vze.2_Nonsense_Mutation_p.S276*|NDRG2_uc001vzd.2_Nonsense_Mutation_p.S276*|NDRG2_uc001vzg.2_Nonsense_Mutation_p.S262*|NDRG2_uc001vzf.2_Nonsense_Mutation_p.S262*|NDRG2_uc010aig.2_Nonsense_Mutation_p.S265*	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	276					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GTCCAGTTTTGAGTTACATTC	0.577													0	0	0	0.00308	0	8	31										C	21486650	G	C	21486650	4	2	107	1	0	0	0	0	0	1	0	0	10252	1294	45	1	304	1	NDRG2	14	21486650	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	1237719	21486650	85862890	112	32816										
RIPK3	11035	broad.mit.edu	37	chr14	24808466	24808466	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	caccttctcgataaccccttCtaggcgcagcacgaattcgt	7	15	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:24808466C>G	uc001wpb.2	-	3	436	c.226G>C	c.(226-228)GAA>CAA	p.E76Q	RIPK3_uc001wpa.2_5'Flank|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Missense_Mutation_p.E76Q	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	76	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		ATAACCCCTTCTAGGCGCAGC	0.572													0	0	0	0.016522	0	22	91										G	24808466	C	G	24808466	3	3	107	1	0	0	0	0	1	0	0	0	13382	922	32	1	1362	1	RIPK3	14	24808466	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	3321816	24808466	82541074	113	32817										
ZFYVE26	23503	broad.mit.edu	37	chr14	68228128	68228128	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tcccgcaggcagctgtgcctCacgtagaagctgatgatggc	13	12	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:68228128C>T	uc001xka.2	-	35	6682	c.6543G>A	c.(6541-6543)GTG>GTA	p.V2181V	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkb.2_Silent_p.V27V|ZFYVE26_uc001xkc.3_Silent_p.V2181V	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2181					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGCTGTGCCTCACGTAGAAGC	0.517													0	0	0	0.021553	0	6	24										T	68228128	C	T	68228128	2	4	107	1	0	0	0	0	0	0	0	1	17665	813	29	1		1	ZFYVE26	14	68228128	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	43419662	68228128	39121412	114	32818										
ZFP36L1	677	broad.mit.edu	37	chr14	69256630	69256631	+	Frame_Shift_Ins	INS	-	-	G													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcccggtggcagcggcggtINSggcagcggcactgggaaacc							TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:69256630_69256631insG	uc001xkh.1	-	2	766_767	c.636_637insC	c.(634-639)GCCACCfs	p.A212fs	ZFP36L1_uc001xki.1_Frame_Shift_Ins_p.A212fs	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	212_213					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		gcagcggcggtggcagcggcAC	0.589											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						30	140	---	---								G	69256631	-	G	69256630	7	5	107	1	0	1	1	0	0	0	0	0	17643	1696	59	0	383	0	ZFP36L1	14	69256630	Frame_Shift_Ins	INS	-	TCGA-GC-A3WC-01A-31D-A22Z-08	1028502	69256630	38092910	115	32819										
NUMB	8650	broad.mit.edu	37	chr14	73753886	73753886	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gttcagtggctgttgtgacaCggaatgatccttctcttgta	11	8	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:73753886C>G	uc001xny.1	-	9	907	c.587G>C	c.(586-588)CGT>CCT	p.R196P	NUMB_uc010aro.1_Missense_Mutation_p.R196P|NUMB_uc010arp.1_Missense_Mutation_p.R185P|NUMB_uc010arq.1_Missense_Mutation_p.R196P|NUMB_uc010arr.1_Missense_Mutation_p.R185P|NUMB_uc001xoa.1_Missense_Mutation_p.R196P|NUMB_uc001xnz.1_Missense_Mutation_p.R185P|NUMB_uc001xob.1_Missense_Mutation_p.R185P|NUMB_uc001xod.1_Missense_Mutation_p.R196P|NUMB_uc001xoc.1_Missense_Mutation_p.R196P|NUMB_uc010ars.1_Missense_Mutation_p.R185P|NUMB_uc001xof.1_Missense_Mutation_p.R160P|NUMB_uc001xog.2_Missense_Mutation_p.R185P|NUMB_uc001xoh.1_Missense_Mutation_p.R185P|NUMB_uc010ttz.1_5'Flank	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	196					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		TGTTGTGACACGGAATGATCC	0.448													0	0	0	0.028581	0	14	83										G	73753886	C	G	73753886	3	3	107	1	0	0	0	0	1	0	0	0	10751	536	19	4	1388	4	NUMB	14	73753886	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	4497256	73753886	33595654	116	32820										
BAG5	9529	broad.mit.edu	37	chr14	104027261	104027261	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtttgcattctgctccaactCtttgagaagacgttctgtct	8	10	4	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr14:104027261C>G	uc001yni.1	-	2	475	c.241G>C	c.(241-243)GAG>CAG	p.E81Q	KLC1_uc010tyd.1_5'Flank|BAG5_uc001ynh.1_Missense_Mutation_p.E122Q|BAG5_uc001ynj.1_Missense_Mutation_p.E81Q|C14orf153_uc001ynl.3_5'Flank|C14orf153_uc010tyc.1_5'Flank	NM_004873	NP_004864	Q9UL15	BAG5_HUMAN	BCL2-associated athanogene 5 isoform b	81	BAG 1.				apoptosis|negative regulation of protein refolding|negative regulation of ubiquitin-protein ligase activity|neuron death|protein folding|regulation of inclusion body assembly	inclusion body|perinuclear region of cytoplasm	chaperone binding|ubiquitin protein ligase binding			ovary(2)	2		Melanoma(154;0.155)	Epithelial(46;0.144)			TGCTCCAACTCTTTGAGAAGA	0.428													0	0	0	0.008361	0	24	109										G	104027261	C	G	104027261	3	3	107	1	0	0	0	0	1	0	0	0	1290	922	32	1	1106	1	BAG5	14	104027261	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	30273375	104027261	3322279	117	32821										
PLCB2	5330	broad.mit.edu	37	chr15	40594185	40594185	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttggggaggtggcaggcactGagagcagcttccacccgctt	15	11	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:40594185G>C	uc001zld.2	-	7	856	c.555C>G	c.(553-555)CTC>CTG	p.L185L	PLCB2_uc010bbo.2_Silent_p.L185L|PLCB2_uc010ucm.1_Silent_p.L185L|PLCB2_uc001zle.3_Silent_p.L185L	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	185					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GGCAGGCACTGAGAGCAGCTT	0.567													0	0	0	0.020292	0	15	62										C	40594185	G	C	40594185	2	2	107	1	0	0	0	0	0	0	0	1	12028	1277	45	1		1	PLCB2	15	40594185	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		40594185	61937207	118	32822										
INO80	54617	broad.mit.edu	37	chr15	41388442	41388442	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gagggccctctccaagtactGaagatagaggggctttgcca	13	10	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:41388442G>A	uc001zni.2	-	2	280	c.67C>T	c.(67-69)CAG>TAG	p.Q23*	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	23	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TCCAAGTACTGAAGATAGAGG	0.483													0	0	0	0.021553	0	5	51										A	41388442	G	A	41388442	4	1	107	1	0	0	0	0	0	1	0	0	7746	1299	45	1	4743	1	INO80	15	41388442	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	794257	41388442	61142950	119	32823										
FBN1	2200	broad.mit.edu	37	chr15	48826273	48826286	+	Splice_Site	DEL	TTACCTTCACATTT	TTACCTTCACATTT	-													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	actgcaaagcataagatttcTtaccttcacatttttgtgac							TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:48826273_48826286delTTACCTTCACATTT	uc001zwx.1	-	8	1190	c.862_splice	c.e8+1	p.D288_splice		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor						heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATAAGATTTCTTACCTTCACATTTTTGTGACACT	0.435																		11	586	---	---								-	48826286	TTACCTTCACATTT	-	48826273	8	5	107	1	0	1	0	1	0	0	1	0	5702	1624	56	0		0	FBN1	15	48826273	Splice_Site	DEL	TTACCTTCACATTT	TCGA-GC-A3WC-01A-31D-A22Z-08	7437831	48826273	53705119	120	32824										
TLN2	83660	broad.mit.edu	37	chr15	62993399	62993399	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggccggaacggcttcagttgTtaacctcacagctggtaagt	12	10	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:62993399T>G	uc002alb.3	+	14	1682	c.1682T>G	c.(1681-1683)GTT>GGT	p.V561G		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	561					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GCTTCAGTTGTTAACCTCACA	0.403													0	0	0	0.014758	0	5	43										G	62993399	T	G	62993399	3	3	107	1	0	0	0	0	1	0	0	0	15945	1725	60	5	1736	5	TLN2	15	62993399	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	14167126	62993399	39537993	121	32825										
MYO9A	4649	broad.mit.edu	37	chr15	72186022	72186022	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	caaaaactcaaaacttacctCtctttggcctggcccagcta	5	14	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:72186022C>G	uc002atl.3	-	26	5613	c.5140G>C	c.(5140-5142)GAG>CAG	p.E1714Q	MYO9A_uc002atn.1_Missense_Mutation_p.E1695Q|MYO9A_uc002atk.2_Missense_Mutation_p.E438Q|MYO9A_uc002atm.1_Missense_Mutation_p.E438Q	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1714	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						AAACTTACCTCTCTTTGGCCT	0.368													0	0	0	0.001984	0	7	34										G	72186022	C	G	72186022	3	3	107	1	0	0	0	0	1	0	0	0	10084	922	32	1	2574	1	MYO9A	15	72186022	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	9192623	72186022	30345370	122	32826										
SENP8	123228	broad.mit.edu	37	chr15	72432366	72432366	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cacgcaaagcaggtagcagaGaaactggaggctttcttagg	13	8	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:72432366G>C	uc002atp.2	+	2	501	c.402G>C	c.(400-402)GAG>GAC	p.E134D		NM_145204	NP_660205	Q96LD8	SENP8_HUMAN	SUMO/sentrin specific peptidase family member 8	134	Protease.				proteolysis		cysteine-type peptidase activity|protein binding			ovary(1)|skin(1)	2						AGGTAGCAGAGAAACTGGAGG	0.453													0	0	0	0.010729	0	11	74										C	72432366	G	C	72432366	3	2	107	1	0	0	0	0	1	0	0	0	14052	933	33	1	404	1	SENP8	15	72432366	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	246344	72432366	30099026	123	32827										
MCTP2	55784	broad.mit.edu	37	chr15	94857556	94857556	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	atgcttctatgacatctcaaCattttgaagaacaatctgtg	6	8	3	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:94857556C>T	uc002btj.2	+	2	576	c.511C>T	c.(511-513)CAT>TAT	p.H171Y	MCTP2_uc010urg.1_Missense_Mutation_p.H171Y|MCTP2_uc002bti.2_Missense_Mutation_p.H171Y|MCTP2_uc010boj.2_5'UTR|MCTP2_uc010bok.2_Missense_Mutation_p.H171Y|MCTP2_uc002btg.3_Missense_Mutation_p.H171Y|MCTP2_uc002bth.3_Missense_Mutation_p.H171Y	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	171					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GACATCTCAACATTTTGAAGA	0.318													0	0	0	0.009096	0	4	21										T	94857556	C	T	94857556	3	4	107	1	0	0	0	0	1	0	0	0	9401	478	17	2	517	2	MCTP2	15	94857556	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	22425190	94857556	7673836	124	32828										
CHSY1	22856	broad.mit.edu	37	chr15	101718791	101718791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gcatgacaatgtcgtccaagGcttccctctgggcggagtcc	12	13	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr15:101718791G>A	uc002bwt.1	-	4	1694	c.1211C>T	c.(1210-1212)GCC>GTC	p.A404V	CHSY1_uc010usd.1_Missense_Mutation_p.A132V	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	404	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GTCGTCCAAGGCTTCCCTCTG	0.532													0	0	0	0.007413	0	19	91										A	101718791	G	A	101718791	3	1	107	1	0	0	0	0	1	0	0	0	3412	1203	42	2	1201	2	CHSY1	15	101718791	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	6861235	101718791	812601	125	32829										
HCFC1R1	54985	broad.mit.edu	37	chr16	3073515	3073517	+	In_Frame_Del	DEL	CTC	CTC	-													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cttggtgctcatgggcacagCtcctcggagaggggagctgg							TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr16:3073515_3073517delCTC	uc002csx.1	-	3	243_245	c.110_112delGAG	c.(109-114)GGAGCT>GCT	p.G37del	HCFC1R1_uc002csy.1_In_Frame_Del_p.G37del|HCFC1R1_uc002csz.1_Intron|THOC6_uc002ctb.2_5'Flank|THOC6_uc002ctd.2_5'Flank|THOC6_uc002ctc.2_5'Flank|THOC6_uc002cta.2_5'Flank	NM_001002018	NP_001002018	Q9NWW0	HPIP_HUMAN	host cell factor C1 regulator 1 (XPO1 dependant)	37						cytoplasm|nucleus					0						ATGGGCACAGCTCCTCGGAGAGG	0.626																		9	43	---	---								-	3073517	CTC	-	3073515	7	5	107	1	0	1	0	1	0	0	0	0	6992	797	28	0	316	0	HCFC1R1	16	3073515	In_Frame_Del	DEL	CTC	TCGA-GC-A3WC-01A-31D-A22Z-08		3073515	87281238	126	32830										
ALG1	56052	broad.mit.edu	37	chr16	5123174	5123174	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttgggccccgagttttccagTacggagtcaaagttgtactt	11	9	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr16:5123174T>C	uc002cym.2	+	3	348	c.307T>C	c.(307-309)TAC>CAC	p.Y103H	ALG1_uc002cyj.2_5'UTR|ALG1_uc002cyn.2_Missense_Mutation_p.Y103H|ALG1_uc010bue.2_5'UTR|ALG1_uc010uxy.1_5'UTR	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	103	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				AGTTTTCCAGTACGGAGTCAA	0.517													0	0	0	0.028581	0	15	50										C	5123174	T	C	5123174	3	2	107	1	0	0	0	0	1	0	0	0	510	1638	57	5	317	5	ALG1	16	5123174	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	2049659	5123174	85231579	127	32831										
PLCG2	5336	broad.mit.edu	37	chr16	81888168	81888168	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tcctatatggcactcagttcGtcctcagcacgctcagcttg	8	14	3	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr16:81888168G>A	uc002fgt.2	+	3	465	c.313G>A	c.(313-315)GTC>ATC	p.V105I	PLCG2_uc010chg.1_Missense_Mutation_p.V105I	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	105	PH.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CACTCAGTTCGTCCTCAGCAC	0.498													0	0	0	0.023175	0	35	121										A	81888168	G	A	81888168	3	1	107	1	0	0	0	0	1	0	0	0	12036	1145	40	2	319	2	PLCG2	16	81888168	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	76764994	81888168	8466585	128	32832										
ATP1B2	482	broad.mit.edu	37	chr17	7557218	7557218	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttgtcaatgtcagtgacactGaaagctgggaccagcatgtt	11	8	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:7557218G>A	uc002gif.1	+	3	884	c.301G>A	c.(301-303)GAA>AAA	p.E101K		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	101	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		CAGTGACACTGAAAGCTGGGA	0.498													0	0	0	0.006122	0	19	84										A	7557218	G	A	7557218	3	1	107	1	0	0	0	0	1	0	0	0	1133	1291	45	1	311	1	ATP1B2	17	7557218	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		7557218	73637992	129	32833										
TP53	7157	broad.mit.edu	37	chr17	7577082	7577082	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tttcttgcggagattctcttCctctgtgcgccggtctctcc	9	14	4	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:7577082C>A	uc002gim.2	-	8	1050	c.856G>T	c.(856-858)GAA>TAA	p.E286*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E286*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E154*|TP53_uc010cng.1_Nonsense_Mutation_p.E154*|TP53_uc002gii.1_Nonsense_Mutation_p.E154*|TP53_uc010cnh.1_Nonsense_Mutation_p.E286*|TP53_uc010cni.1_Nonsense_Mutation_p.E286*|TP53_uc002gij.2_Nonsense_Mutation_p.E286*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(52)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTCTCTTCCTCTGTGCGC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	6.94344e-10	0.006122	7.25128e-10	19	53										A	7577082	C	A	7577082	4	1	107	1	0	0	0	0	0	1	0	0	16378	864	30	3	430	3	TP53	17	7577082	Nonsense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	19864	7577082	73618128	130	32834										
TP53	7157	broad.mit.edu	37	chr17	7578534	7578534	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttggccagttggcaaaacatCttgttgagggcaggggagta	15	6	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:7578534C>G	uc002gim.2	-	5	590	c.396G>C	c.(394-396)AAG>AAC	p.K132N	TP53_uc002gig.1_Missense_Mutation_p.K132N|TP53_uc002gih.2_Missense_Mutation_p.K132N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132N|TP53_uc010cni.1_Missense_Mutation_p.K132N|TP53_uc002gij.2_Missense_Mutation_p.K132N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39N|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.M133fs*16(1)|p.V73fs*9(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.013537	0	11	54										G	7578534	C	G	7578534	3	3	107	1	0	0	0	0	1	0	0	0	16378	912	32	1	902	1	TP53	17	7578534	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	1452	7578534	73616676	131	32835										
RICH2	9912	broad.mit.edu	37	chr17	12819241	12819241	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	atgctgaaactctgtggagaGacggaggacaagctggctca	14	8	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:12819241G>C	uc002gnr.3	+	5	627	c.300G>C	c.(298-300)GAG>GAC	p.E100D	RICH2_uc010vvk.1_Missense_Mutation_p.E100D|RICH2_uc010vvl.1_Missense_Mutation_p.E100D|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Missense_Mutation_p.E100D|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	100	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TCTGTGGAGAGACGGAGGACA	0.493													0	0	0	0.013537	0	12	27										C	12819241	G	C	12819241	3	2	107	1	0	0	0	0	1	0	0	0	13357	933	33	1	318	1	RICH2	17	12819241	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	5240707	12819241	68375969	132	32836										
RICH2	9912	broad.mit.edu	37	chr17	12819326	12819326	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcccctgtttttgctggcgGaggtaagcagcaggagtgag	16	8	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:12819326G>A	uc002gnr.3	+	5	712	c.385G>A	c.(385-387)GAG>AAG	p.E129K	RICH2_uc010vvk.1_Missense_Mutation_p.E129K|RICH2_uc010vvl.1_Missense_Mutation_p.E129K|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Missense_Mutation_p.E129K|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	129	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TTTGCTGGCGGAGGTAAGCAG	0.512													0	0	0	0.00308	0	8	26										A	12819326	G	A	12819326	3	1	107	1	0	0	0	0	1	0	0	0	13357	1175	41	1	403	1	RICH2	17	12819326	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	85	12819326	68375884	133	32837										
LGALS9C	654346	broad.mit.edu	37	chr17	18394613	18394613	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	acagtcatccacacggtgcaGagtgcctctggacagatgtt	11	11	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:18394613G>A	uc002gtw.2	+	7	673	c.603G>A	c.(601-603)CAG>CAA	p.Q201Q	LGALS9C_uc010vyb.1_Silent_p.Q113Q	NM_001040078	NP_001035167	Q6DKI2	LEG9C_HUMAN	galectin 9 like	201							sugar binding			ovary(1)	1						ACACGGTGCAGAGTGCCTCTG	0.542													0	0	0	0.010818	0	30	168										A	18394613	G	A	18394613	2	1	107	1	0	0	0	0	0	0	0	1	8750	933	33	1		1	LGALS9C	17	18394613	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	5575287	18394613	62800597	134	32838										
ACCN1	40	broad.mit.edu	37	chr17	32483149	32483149	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggccttctgccgcagggcctCcagcacggaggggtcagcca	15	15	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:32483149C>T	uc002hhu.2	-	1	677	c.403G>A	c.(403-405)GAG>AAG	p.E135K		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	135	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	CGCAGGGCCTCCAGCACGGAG	0.597													0	0	0	0.027356	0	26	119										T	32483149	C	T	32483149	3	4	107	1	0	0	0	0	1	0	0	0	128	864	30	1	1887	1	ACCN1	17	32483149	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	14088536	32483149	48712061	135	32839										
KRT9	3857	broad.mit.edu	37	chr17	39727637	39727637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	catcaatagtgttataataaGgggagtagttcttctggata	10	4	3	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:39727637G>A	uc002hxe.3	-	1	674	c.608C>T	c.(607-609)CCT>CTT	p.P203L	JUP_uc010wfs.1_Intron	NM_000226	NP_000217	P35527	K1C9_HUMAN	keratin 9	203	Rod.|Linker 1.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Breast(137;0.000307)				GTTATAATAAGGGGAGTAGTT	0.443													0	0	0	0.007291	0	30	143										A	39727637	G	A	39727637	3	1	107	1	0	0	0	0	1	0	0	0	8501	1000	35	2	1291	2	KRT9	17	39727637	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	7244488	39727637	41467573	136	32840										
MFSD11	79157	broad.mit.edu	37	chr17	74774367	74774367	+	Missense_Mutation	SNP	C	C	T													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgggttttttggaacaatttCtttcttcactgtggaatggg					rs3198672		TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:74774367C>T	uc002jta.2	+	14	2256	c.1283C>T	c.(1282-1284)TCT>TTT	p.S428F	MFSD11_uc002jtb.2_Missense_Mutation_p.S428F|MFSD11_uc010dha.2_Missense_Mutation_p.S376F|MFSD11_uc002jtc.2_Missense_Mutation_p.S428F|MFSD11_uc002jtd.3_Missense_Mutation_p.S428F|MFSD11_uc010dhb.2_Missense_Mutation_p.S376F|MFSD11_uc002jte.2_Missense_Mutation_p.S428F	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	428	Helical; (Potential).					integral to membrane				ovary(1)	1						GGAACAATTTCTTTCTTCACT	0.493													0	0	0	0.010729	0	11	79										T	74774367	C	T	74774367	3	4	107	1	0	0	0	0	1	0	0	0	9529	913	32	1	1333	1	MFSD11	17	74774367	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	35046730	74774367	6420843	137	32841	163	2								
MFSD11	79157	broad.mit.edu	37	chr17	74774374	74774374	+	Silent	SNP	C	C	T													0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tttggaacaatttctttcttCactgtggaatgggaagctgc							TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:74774374C>T	uc002jta.2	+	14	2263	c.1290C>T	c.(1288-1290)TTC>TTT	p.F430F	MFSD11_uc002jtb.2_Silent_p.F430F|MFSD11_uc010dha.2_Silent_p.F378F|MFSD11_uc002jtc.2_Silent_p.F430F|MFSD11_uc002jtd.3_Silent_p.F430F|MFSD11_uc010dhb.2_Silent_p.F378F|MFSD11_uc002jte.2_Silent_p.F430F	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	430	Helical; (Potential).					integral to membrane				ovary(1)	1						TTTCTTTCTTCACTGTGGAAT	0.498													0	0	0	0.016723	0	11	81										T	74774374	C	T	74774374	2	4	107	1	0	0	0	0	0	0	0	1	9529	825	29	1		1	MFSD11	17	74774374	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	7	74774374	6420836	138	32842	163	2								
P4HB	5034	broad.mit.edu	37	chr17	79803505	79803505	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cactttgacggcctccacctCgttggcagtcgagtccatct	9	15	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:79803505C>G	uc002kbn.1	-	9	1488	c.1291G>C	c.(1291-1293)GAG>CAG	p.E431Q	P4HB_uc002kbl.1_Missense_Mutation_p.E108Q|P4HB_uc002kbm.1_Missense_Mutation_p.E108Q	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	431	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GCCTCCACCTCGTTGGCAGTC	0.582													0	0	0	0.009096	0	4	25										G	79803505	C	G	79803505	3	3	107	1	0	0	0	0	1	0	0	0	11359	893	31	1	247	1	P4HB	17	79803505	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	5029131	79803505	1391705	139	32843										
P4HB	5034	broad.mit.edu	37	chr17	79804359	79804359	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tctgtgatcctctctgccgtCagctcctccgattcgggctt	9	15	3	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr17:79804359C>T	uc002kbn.1	-	7	1199	c.1002G>A	c.(1000-1002)CTG>CTA	p.L334L	P4HB_uc002kbl.1_Silent_p.L11L|P4HB_uc002kbm.1_Silent_p.L11L	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	334					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			TCTCTGCCGTCAGCTCCTCCG	0.632													0	0	0	0.007291	0	28	129										T	79804359	C	T	79804359	2	4	107	1	0	0	0	0	0	0	0	1	11359	813	29	1		1	P4HB	17	79804359	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	854	79804359	1390851	140	32844										
VAPA	9218	broad.mit.edu	37	chr18	9931810	9931810	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	atttttaaactttacaggccCcttcacagatgtagtcacta	5	10	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr18:9931810C>T	uc002kok.2	+	2	382	c.83C>T	c.(82-84)CCC>CTC	p.P28L	VAPA_uc002koj.2_Missense_Mutation_p.P28L	NM_194434	NP_919415	Q9P0L0	VAPA_HUMAN	vesicle-associated membrane protein-associated	28	Cytoplasmic (Potential).|MSP.				cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity				0						TTTACAGGCCCCTTCACAGAT	0.333													0	0	0	0.010504	0	21	88										T	9931810	C	T	9931810	3	4	107	1	0	0	0	0	1	0	0	0	17118	623	22	2	89	2	VAPA	18	9931810	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08		9931810	68145438	141	32845										
CABLES1	91768	broad.mit.edu	37	chr18	20832925	20832925	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gttcccctgtctgttacagaCaacagtgattgactacgtga	9	10	1	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr18:20832925C>A	uc002kuc.2	+	8	1448	c.1448C>A	c.(1447-1449)ACA>AAA	p.T483K	C18orf45_uc010xaq.1_Intron|CABLES1_uc002kub.2_5'UTR|CABLES1_uc002kud.2_Missense_Mutation_p.T218K	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	483	Interacts with CDK3 (By similarity).				blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CTGTTACAGACAACAGTGATT	0.438													1	0	5.50884e-06	0.013537	5.6419e-06	11	44										A	20832925	C	A	20832925	3	1	107	1	0	0	0	0	1	0	0	0	2529	492	17	4	1532	4	CABLES1	18	20832925	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	10901115	20832925	57244323	142	32846										
KEAP1	9817	broad.mit.edu	37	chr19	10610363	10610363	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ccacctccatgccctgctccCgcagcccgttggtgaacatg	9	18	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:10610363C>G	uc002moq.1	-	2	503	c.347G>C	c.(346-348)CGG>CCG	p.R116P	KEAP1_uc002mor.1_Missense_Mutation_p.R116P	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	116	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCCCTGCTCCCGCAGCCCGTT	0.612													0	0	0	0.008291	0	11	58										G	10610363	C	G	10610363	3	3	107	1	0	0	0	0	1	0	0	0	8141	652	23	4	1547	4	KEAP1	19	10610363	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08		10610363	48518620	143	32847										
CACNA1A	773	broad.mit.edu	37	chr19	13476201	13476201	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	aaccctatgattgcaaaaatAaggattgcaaaaaataggag	8	5	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:13476201A>G	uc010dze.2	-	5	950	c.714T>C	c.(712-714)CTT>CTC	p.L238L	CACNA1A_uc002mwy.3_Silent_p.L238L	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	238	I.|Helical; Name=S5 of repeat I; (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TTGCAAAAATAAGGATTGCAA	0.458													0	0	0	0.016723	0	14	95										G	13476201	A	G	13476201	2	3	107	1	0	0	0	0	0	0	0	1	2538	349	13	5		5	CACNA1A	19	13476201	Silent	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	2865838	13476201	45652782	144	32848										
CPAMD8	27151	broad.mit.edu	37	chr19	17088246	17088246	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cccttctccattctccctgaCgtagaagaccagcaggcgac	8	16	2	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:17088246C>T	uc002nfb.2	-	15	1863	c.1831G>A	c.(1831-1833)GTC>ATC	p.V611I		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	564						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TTCTCCCTGACGTAGAAGACC	0.592													0	0	0	0.00499	0	16	94										T	17088246	C	T	17088246	3	4	107	1	0	0	0	0	1	0	0	0	3795	536	19	2	4079	2	CPAMD8	19	17088246	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	3612045	17088246	42040737	145	32849										
PLVAP	83483	broad.mit.edu	37	chr19	17476791	17476791	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcgtcttcaccttctgattCagcatgaagagcaaggctaa	9	10	4	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:17476791C>T	uc002ngk.1	-	3	533	c.483G>A	c.(481-483)CTG>CTA	p.L161L		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	161	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CCTTCTGATTCAGCATGAAGA	0.572													0	0	0	0.010729	0	12	58										T	17476791	C	T	17476791	2	4	107	1	0	0	0	0	0	0	0	1	12116	813	29	1		1	PLVAP	19	17476791	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	388545	17476791	41652192	146	32850										
PLVAP	83483	broad.mit.edu	37	chr19	17487766	17487766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggcggaagctggcattgatgCggtccaggtcgcggcgagca	18	10	0	1	rs144117840		TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:17487766C>T	uc002ngk.1	-	1	382	c.332G>A	c.(331-333)CGC>CAC	p.R111H		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	111	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						GGCATTGATGCGGTCCAGGTC	0.488													0	0	0	0.010729	0	12	66										T	17487766	C	T	17487766	3	4	107	1	0	0	0	0	1	0	0	0	12116	768	27	2	1020	2	PLVAP	19	17487766	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	10975	17487766	41641217	147	32851										
IL12RB1	3594	broad.mit.edu	37	chr19	18174767	18174767	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctgcaccgtgtaggctacacCagcccgcaggccactgaggg	13	15	0	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:18174767C>T	uc002nhw.1	-	13	1601	c.1537G>A	c.(1537-1539)GGT>AGT	p.G513S	IL12RB1_uc010xqb.1_Missense_Mutation_p.G513S|IL12RB1_uc002nhx.1_Missense_Mutation_p.G553S	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	513	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TAGGCTACACCAGCCCGCAGG	0.637													0	0	0	0.001984	0	6	29										T	18174767	C	T	18174767	3	4	107	1	0	0	0	0	1	0	0	0	7626	594	21	2	471	2	IL12RB1	19	18174767	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	687001	18174767	40954216	148	32852										
ISYNA1	51477	broad.mit.edu	37	chr19	18547041	18547041	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cggcgaagagcgtggagggcGacacctccagaccgagctgt	16	12	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:18547041G>A	uc002njd.1	-	7	826	c.776C>T	c.(775-777)TCG>TTG	p.S259L	ISYNA1_uc002nja.1_Missense_Mutation_p.S131L|ISYNA1_uc002njb.1_Missense_Mutation_p.S177L|ISYNA1_uc002njc.1_Missense_Mutation_p.S109L|ISYNA1_uc010xqh.1_Missense_Mutation_p.S57L|ISYNA1_uc002nje.1_Missense_Mutation_p.S205L|ISYNA1_uc002njf.1_Missense_Mutation_p.S109L	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	259					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						CGTGGAGGGCGACACCTCCAG	0.677													0	0	0	0.001984	0	7	48										A	18547041	G	A	18547041	3	1	107	1	0	0	0	0	1	0	0	0	7867	1059	37	1	920	1	ISYNA1	19	18547041	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	372274	18547041	40581942	149	32853										
MLL4	9757	broad.mit.edu	37	chr19	36221656	36221656	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gatgctcggaggcgctgctgGtatcggtgccgaattctgga	16	9	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:36221656G>A	uc010eei.2	+	27	5325	c.5325G>A	c.(5323-5325)TGG>TGA	p.W1775*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1775	FYR N-terminal.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCGCTGCTGGTATCGGTGCC	0.597													0	0	0	0.008291	0	11	70										A	36221656	G	A	36221656	4	1	107	1	0	0	0	0	0	1	0	0	9623	1270	44	2	5427	2	MLL4	19	36221656	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	17674615	36221656	22907327	150	32854										
ZNF404	342908	broad.mit.edu	37	chr19	44378165	44378165	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttccatgtctcctgatggtaCgcatttacttcataatttct	5	10	3	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:44378165C>T	uc002oxs.3	-	2	201	c.192G>A	c.(190-192)GCG>GCA	p.A64A		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				CCTGATGGTACGCATTTACTT	0.318													0	0	0	0.008291	0	11	51										T	44378165	C	T	44378165	2	4	107	1	0	0	0	0	0	0	0	1	17883	523	19	2		2	ZNF404	19	44378165	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	8156509	44378165	14750818	151	32855										
IRF2BP1	26145	broad.mit.edu	37	chr19	46387808	46387808	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ctcagcggagtacgggccgcCgggtgccacccagtgccgtt	15	15	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:46387808C>T	uc002pds.1	-	1	1569	c.1225G>A	c.(1225-1227)GGC>AGC	p.G409S		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		TACGGGCCGCCGGGTGCCACC	0.721													0	0	0	0.008291	0	10	53										T	46387808	C	T	46387808	3	4	107	1	0	0	0	0	1	0	0	0	7829	652	23	2	533	2	IRF2BP1	19	46387808	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	2009643	46387808	12741175	152	32856										
PPFIA3	8541	broad.mit.edu	37	chr19	49649227	49649227	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gaaacgtgtggatgacacacGaggagatggagtcccttacg	14	8	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:49649227G>T	uc002pmr.2	+	22	3105	c.2773G>T	c.(2773-2775)GAG>TAG	p.E925*	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Nonsense_Mutation_p.E793*|PPFIA3_uc002pmt.2_Nonsense_Mutation_p.E73*|PPFIA3_uc002pmu.1_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	925						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GATGACACACGAGGAGATGGA	0.647											OREG0025618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.64293e-13	0.01892	1.75026e-13	24	130										T	49649227	G	T	49649227	4	4	107	1	0	0	0	0	0	1	0	0	12311	1059	37	3	2855	3	PPFIA3	19	49649227	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	3261419	49649227	9479756	153	32857										
MYBPC2	4606	broad.mit.edu	37	chr19	50939937	50939937	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	accgtgggtattaccgcctcGaggtcaaagccaaggacacc	11	13	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr19:50939937G>C	uc002psf.2	+	5	460	c.409G>C	c.(409-411)GAG>CAG	p.E137Q		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	137	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TTACCGCCTCGAGGTCAAAGC	0.612													0	0	0	0.021523	0	24	115										C	50939937	G	C	50939937	3	2	107	1	0	0	0	0	1	0	0	0	10012	1059	37	1	427	1	MYBPC2	19	50939937	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	1290710	50939937	8189046	154	32858										
TRIB3	57761	broad.mit.edu	37	chr20	377161	377161	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tccttcgtcgggagccagctGaacggctcacagccacaggc	12	15	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr20:377161G>A	uc002wdm.2	+	4	1410	c.904G>A	c.(904-906)GAA>AAA	p.E302K	TRIB3_uc002wdn.2_Missense_Mutation_p.E329K	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	302	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GGAGCCAGCTGAACGGCTCAC	0.687													0	0	0	0.00499	0	17	101										A	377161	G	A	377161	3	1	107	1	0	0	0	0	1	0	0	0	16481	1291	45	1	914	1	TRIB3	20	377161	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		377161	62648359	155	32859										
KIF16B	55614	broad.mit.edu	37	chr20	16360474	16360474	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtccagttcttgaaatatctGaaacttctcagccttctcgt	6	11	4	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr20:16360474G>A	uc002wpg.1	-	19	2331	c.2173C>T	c.(2173-2175)CAG>TAG	p.Q725*	KIF16B_uc002wpe.1_Nonsense_Mutation_p.Q107*|KIF16B_uc002wpf.1_Nonsense_Mutation_p.Q107*|KIF16B_uc010gch.1_Nonsense_Mutation_p.Q725*|KIF16B_uc010gci.1_Nonsense_Mutation_p.Q725*|KIF16B_uc010gcj.1_Nonsense_Mutation_p.Q736*	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	725	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TGAAATATCTGAAACTTCTCA	0.443													0	0	0	0.008361	0	29	108										A	16360474	G	A	16360474	4	1	107	1	0	0	0	0	0	1	0	0	8278	1299	45	1	1812	1	KIF16B	20	16360474	Nonsense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	15983313	16360474	46665046	156	32860										
MYT1	4661	broad.mit.edu	37	chr20	62836958	62836958	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agctggagggcgctgaggctGagcacctggtgtccaagagg	18	9	0	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr20:62836958G>A	uc002yii.2	+	6	566	c.202G>A	c.(202-204)GAG>AAG	p.E68K	MYT1_uc002yih.2_Missense_Mutation_p.E68K|MYT1_uc002yij.2_5'Flank	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	68					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CGCTGAGGCTGAGCACCTGGT	0.622													0	0	0	0.028581	0	15	74										A	62836958	G	A	62836958	3	1	107	1	0	0	0	0	1	0	0	0	10106	1291	45	1	216	1	MYT1	20	62836958	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	46476484	62836958	188562	157	32861										
KRTAP26-1	388818	broad.mit.edu	37	chr21	31691783	31691783	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggtcagaggttggcaaccacTgaacagaggccccagaggtc	14	11	1	4			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr21:31691783T>A	uc002ynw.2	-	1	825	c.571A>T	c.(571-573)AGT>TGT	p.S191C		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	191						intermediate filament				ovary(1)	1						TGGCAACCACTGAACAGAGGC	0.532													0	0	0	0.01441	0	54	314										A	31691783	T	A	31691783	3	1	107	1	0	0	0	0	1	0	0	0	8543	1580	55	5	65	5	KRTAP26-1	21	31691783	Missense_Mutation	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08		31691783	16438112	158	32862										
HUNK	30811	broad.mit.edu	37	chr21	33371331	33371331	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ccccaattgtgtgaaaagccGaggccggttccctatgatgg	12	11	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr21:33371331G>A	uc002yph.2	+	11	2339	c.1979G>A	c.(1978-1980)CGA>CAA	p.R660Q		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	660					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						GTGAAAAGCCGAGGCCGGTTC	0.612													0	0	0	0.024245	0	16	97										A	33371331	G	A	33371331	3	1	107	1	0	0	0	0	1	0	0	0	7458	1058	37	1	2021	1	HUNK	21	33371331	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	1679548	33371331	14758564	159	32863										
AGPAT3	56894	broad.mit.edu	37	chr21	45389127	45389127	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gacaccgtggtcgaagggctGaggcgcctgtcggactaccc	15	13	0	1	rs115875072	byFrequency	TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr21:45389127G>A	uc002zdv.2	+	5	699	c.477G>A	c.(475-477)CTG>CTA	p.L159L	AGPAT3_uc002zdw.2_Silent_p.L159L|AGPAT3_uc002zdx.2_Silent_p.L246L|AGPAT3_uc002zdy.2_Silent_p.L97L	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	159	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		TCGAAGGGCTGAGGCGCCTGT	0.632													0	0	0	0.008361	0	29	86										A	45389127	G	A	45389127	2	1	107	1	0	0	0	0	0	0	0	1	388	1277	45	1		1	AGPAT3	21	45389127	Silent	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	12017796	45389127	2740768	160	32864										
ARVCF	421	broad.mit.edu	37	chr22	19960805	19960805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cggcggagcctgtgcattgcGcacattccgcacaagctcag	12	14	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr22:19960805G>A	uc002zqz.2	-	14	2546	c.2275C>T	c.(2275-2277)CGC>TGC	p.R759C	ARVCF_uc002zqy.2_Missense_Mutation_p.R275C	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	759	ARM 9.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TGTGCATTGCGCACATTCCGC	0.637													0	0	0	0.014758	0	5	20										A	19960805	G	A	19960805	3	1	107	1	0	0	0	0	1	0	0	0	1003	1087	38	2	637	2	ARVCF	22	19960805	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		19960805	31343761	161	32865										
MYO18B	84700	broad.mit.edu	37	chr22	26193971	26193971	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttgcccagctccagggtgccAtggagatgctcggcatctca	12	13	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr22:26193971A>G	uc003abz.1	+	12	2678	c.2428A>G	c.(2428-2430)ATG>GTG	p.M810V	MYO18B_uc003aca.1_Missense_Mutation_p.M691V|MYO18B_uc010guy.1_Missense_Mutation_p.M691V|MYO18B_uc010guz.1_Missense_Mutation_p.M691V|MYO18B_uc011aka.1_Intron|MYO18B_uc011akb.1_Missense_Mutation_p.M323V	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	810	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCAGGGTGCCATGGAGATGCT	0.617													0	0	0	0.021553	0	6	128										G	26193971	A	G	26193971	3	3	107	1	0	0	0	0	1	0	0	0	10066	217	8	5	2470	5	MYO18B	22	26193971	Missense_Mutation	SNP	A	TCGA-GC-A3WC-01A-31D-A22Z-08	6233166	26193971	25110595	162	32866										
TMPRSS6	164656	broad.mit.edu	37	chr22	37465272	37465272	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtagtcatggctgtcctcttCgtggtacgggtgcaggagca	15	9	2	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr22:37465272C>G	uc003aqs.1	-	16	2095	c.1981G>C	c.(1981-1983)GAA>CAA	p.E661Q	TMPRSS6_uc003aqt.1_Missense_Mutation_p.E652Q	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	661	Peptidase S1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						CTGTCCTCTTCGTGGTACGGG	0.692													0	0	0	0.014758	0	4	21										G	37465272	C	G	37465272	3	3	107	1	0	0	0	0	1	0	0	0	16248	893	31	1	466	1	TMPRSS6	22	37465272	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	11271301	37465272	13839294	163	32867										
PICK1	9463	broad.mit.edu	37	chr22	38470962	38470962	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	gtgctgcgggatgccgacgtCttccccatcgaggtagacct	13	13	1	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr22:38470962C>G	uc003auq.2	+	13	1461	c.1071C>G	c.(1069-1071)GTC>GTG	p.V357V	PICK1_uc003aur.2_Silent_p.V357V|PICK1_uc003aus.2_Silent_p.V357V|PICK1_uc003aut.2_Silent_p.V357V	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	357	AH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					ATGCCGACGTCTTCCCCATCG	0.532													0	0	0	0.024245	0	16	59										G	38470962	C	G	38470962	2	3	107	1	0	0	0	0	0	0	0	1	11881	900	32	1		1	PICK1	22	38470962	Silent	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	1005690	38470962	12833604	164	32868										
CACNA1I	8911	broad.mit.edu	37	chr22	40030684	40030684	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cataggtgtgcagctctgggCgggcctgctgcgtaaccgct	15	12	1	0	rs61417992		TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chr22:40030684C>A	uc003ayc.2	+	5	695	c.695C>A	c.(694-696)GCG>GAG	p.A232E	CACNA1I_uc003ayd.2_Missense_Mutation_p.A232E|CACNA1I_uc003aye.2_Missense_Mutation_p.A147E|CACNA1I_uc003ayf.2_Missense_Mutation_p.A147E	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	232	I.|Helical; Name=S5 of repeat I; (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CAGCTCTGGGCGGGCCTGCTG	0.562													1	0	3.62473e-10	0.012319	3.80417e-10	21	134										A	40030684	C	A	40030684	3	1	107	1	0	0	0	0	1	0	0	0	2546	768	27	4	713	4	CACNA1I	22	40030684	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	1559722	40030684	11273882	165	32869										
TLR7	51284	broad.mit.edu	37	chrX	12906301	12906301	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tatcaccagactgttgctatGatgcttttattgtgtatgac	8	7	1	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:12906301G>C	uc004cvc.2	+	3	2813	c.2674G>C	c.(2674-2676)GAT>CAT	p.D892H		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	892	TIR.|Cytoplasmic (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CTGTTGCTATGATGCTTTTAT	0.433													0	0	0	0.00632	0	29	187										C	12906301	G	C	12906301	3	2	107	1	0	0	0	0	1	0	0	0	15953	1290	45	1	2680	1	TLR7	23	12906301	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08		12906301	142364259	166	32870										
GLRA2	2742	broad.mit.edu	37	chrX	14550396	14550396	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agaccatgactccaggtctgGaaaacaaccttcacagaccc	7	14	2	3			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:14550396G>C	uc010nep.2	+	3	436	c.104G>C	c.(103-105)GGA>GCA	p.G35A	GLRA2_uc010neq.2_Missense_Mutation_p.G35A|GLRA2_uc004cwe.3_Missense_Mutation_p.G35A|GLRA2_uc011mio.1_5'UTR|GLRA2_uc011mip.1_Missense_Mutation_p.G13A	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	35	Extracellular (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	TCCAGGTCTGGAAAACAACCT	0.413													0	0	0	0.010504	0	21	78										C	14550396	G	C	14550396	3	2	107	1	0	0	0	0	1	0	0	0	6455	1174	41	1	110	1	GLRA2	23	14550396	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	1644095	14550396	140720164	167	32871										
PHEX	5251	broad.mit.edu	37	chrX	22094533	22094533	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ggagaaatcaatcagtagaaGgcgggacaccgaagccatac	12	9	2	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:22094533G>C	uc004dah.2	+	4	580	c.377G>C	c.(376-378)AGG>ACG	p.R126T	PHEX_uc011mjr.1_Missense_Mutation_p.R126T|PHEX_uc011mjs.1_Missense_Mutation_p.R29T	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	126	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						ATCAGTAGAAGGCGGGACACC	0.383													0	0	0	0.021553	0	5	35										C	22094533	G	C	22094533	3	2	107	1	0	0	0	0	1	0	0	0	11819	1000	35	4	391	4	PHEX	23	22094533	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	7544137	22094533	133176027	168	32872										
DGKK	139189	broad.mit.edu	37	chrX	50117981	50117981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tgcactcaccagcttttcatCcaggaaagctgtggtgtcat	9	11	3	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:50117981C>T	uc010njr.1	-	26	3550	c.3490G>A	c.(3490-3492)GAT>AAT	p.D1164N		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1164					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					AGCTTTTCATCCAGGAAAGCT	0.473													0	0	0	0.014758	0	5	26										T	50117981	C	T	50117981	3	4	107	1	0	0	0	0	1	0	0	0	4472	855	30	1	341	1	DGKK	23	50117981	Missense_Mutation	SNP	C	TCGA-GC-A3WC-01A-31D-A22Z-08	28023448	50117981	105152579	169	32873										
FGD1	2245	broad.mit.edu	37	chrX	54496484	54496484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	tctctccatcaggggcactgGgatttctctgtccttctctt	8	13	4	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:54496484G>A	uc004dtg.2	-	4	1800	c.1066C>T	c.(1066-1068)CCA>TCA	p.P356S	FGD1_uc011moi.1_Missense_Mutation_p.P114S	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	356					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AGGGGCACTGGGATTTCTCTG	0.478													0	0	0	0.004482	0	9	33										A	54496484	G	A	54496484	3	1	107	1	0	0	0	0	1	0	0	0	5832	1232	43	2	1879	2	FGD1	23	54496484	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	4378503	54496484	100774076	170	32874										
TRPC5	7224	broad.mit.edu	37	chrX	111019559	111019559	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	acttagaggcgagttgtaacTtgttcttcctgtccatcacc	8	11	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:111019559T>C	uc004epl.1	-	11	3823	c.2904A>G	c.(2902-2904)CAA>CAG	p.Q968Q		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	968	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						GAGTTGTAACTTGTTCTTCCT	0.423													0	0	0	0.014758	0	5	62										C	111019559	T	C	111019559	2	2	107	1	0	0	0	0	0	0	0	1	16579	1606	56	5		5	TRPC5	23	111019559	Silent	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	56523075	111019559	44251001	171	32875										
DOCK11	139818	broad.mit.edu	37	chrX	117814457	117814457	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	ttttataggtaaatgccaaaGagcttgatccaaaatatgct	7	6	0	2			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:117814457G>A	uc004eqp.2	+	49	5536	c.5473G>A	c.(5473-5475)GAG>AAG	p.E1825K	DOCK11_uc004eqq.2_Missense_Mutation_p.E1604K	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1825	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						AAATGCCAAAGAGCTTGATCC	0.289													0	0	0	0.016723	0	13	66										A	117814457	G	A	117814457	3	1	107	1	0	0	0	0	1	0	0	0	4686	943	33	1	5667	1	DOCK11	23	117814457	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	6794898	117814457	37456103	172	32876										
CDR1	1038	broad.mit.edu	37	chrX	139866027	139866027	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	cagtcttccagaaaatccacGtcttcccaacaatccaagtc	4	15	2	1			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:139866027G>C	uc004fbg.1	-	1	697	c.505C>G	c.(505-507)CGT>GGT	p.R169G	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	169	5.|6 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				GAAAATCCACGTCTTCCCAAC	0.423													0	0	0	0.01441	0	63	266										C	139866027	G	C	139866027	3	2	107	1	0	0	0	0	1	0	0	0	3171	1145	40	4	287	4	CDR1	23	139866027	Missense_Mutation	SNP	G	TCGA-GC-A3WC-01A-31D-A22Z-08	22051570	139866027	15404533	173	32877										
MAGEA8	4107	broad.mit.edu	37	chrX	149013352	149013352	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.346820809248555	60	5.87200221955168e-17	3.22659430122117	4.3862977602108	2.62038567493113	0.597826328576406	0.719605765879007	41	agcacctccccggacccagcTcacctggagtccctgttccg	9	19	1	0			TCGA-GC-A3WC-01A-31D-A22Z-08	TCGA-GC-A3WC-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4892732c-1a8e-4481-b69a-0485ad5c80af	8128a926-0322-4102-b121-bfd6e641e3bb	g.chrX:149013352T>C	uc004fdw.1	+	3	521	c.306T>C	c.(304-306)GCT>GCC	p.A102A		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	102											0	Acute lymphoblastic leukemia(192;6.56e-05)					CGGACCCAGCTCACCTGGAGT	0.557													0	0	0	0.007291	0	30	145										C	149013352	T	C	149013352	2	2	107	1	0	0	0	0	0	0	0	1	9171	1538	54	5		5	MAGEA8	23	149013352	Silent	SNP	T	TCGA-GC-A3WC-01A-31D-A22Z-08	9147325	149013352	6257208	174	32878										
PIK3CD	5293	broad.mit.edu	37	chr1	9775949	9775949	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtgcgacccagaagtgaacgActttcgcgccaagatgtgcc	12	12	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:9775949A>G	uc001aqb.3	+	5	621	c.413A>G	c.(412-414)GAC>GGC	p.D138G	PIK3CD_uc010oaf.1_Missense_Mutation_p.D138G|PIK3CD_uc001aqe.3_Missense_Mutation_p.D138G	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	138					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GAAGTGAACGACTTTCGCGCC	0.687													0	0	0	0.047766	0	9	38										G	9775949	A	G	9775949	3	3	108	1	0	0	0	0	1	0	0	0	11915	275	10	5	423	5	PIK3CD	1	9775949	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08		9775949	239474672	1	32879										
FBXO42	54455	broad.mit.edu	37	chr1	16579618	16579618	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggaccgccacaccctccgagGattaagatagttgcatcatc	9	13	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:16579618G>A	uc001ayg.2	-	8	1110	c.894C>T	c.(892-894)ATC>ATT	p.I298I	FBXO42_uc001aye.3_Silent_p.I16I|FBXO42_uc001ayf.2_Silent_p.I205I	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	298	Kelch 4.									upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		ACCCTCCGAGGATTAAGATAG	0.438													0	0	0	0.124865	0	41	16										A	16579618	G	A	16579618	2	1	108	1	0	0	0	0	0	0	0	1	5751	1164	41	1		1	FBXO42	1	16579618	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	6803669	16579618	232671003	2	32880										
HSPG2	3339	broad.mit.edu	37	chr1	22202880	22202880	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caggctgaagtgaccaggctCctcagaggccccatgcaact	11	14	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:22202880C>T	uc001bfj.2	-	23	2885	c.2845G>A	c.(2845-2847)GAG>AAG	p.E949K	HSPG2_uc009vqd.2_Missense_Mutation_p.E950K	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	949	Laminin IV type A 2.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGACCAGGCTCCTCAGAGGCC	0.667													0	0	0	0.009096	0	4	16										T	22202880	C	T	22202880	3	4	108	1	0	0	0	0	1	0	0	0	7430	864	30	1	10630	1	HSPG2	1	22202880	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	5623262	22202880	227047741	3	32881										
MACF1	23499	broad.mit.edu	37	chr1	39799983	39799983	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cagacctgaaaagagaaatcCaggaggttcaggcctttact	10	9	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:39799983C>T	uc010oiu.1	+	1	3174	c.3043C>T	c.(3043-3045)CAG>TAG	p.Q1015*	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2580					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGAGAAATCCAGGAGGTTCA	0.378													0	0	0	0.139131	0	92	39										T	39799983	C	T	39799983	4	4	108	1	0	0	0	0	0	1	0	0	9144	595	21	2	7814	2	MACF1	1	39799983	Nonsense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	17597103	39799983	209450638	4	32882										
MACF1	23499	broad.mit.edu	37	chr1	39838193	39838193	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtaagggaactctggtggaaGaaatcaattgcaaaggtact	12	5	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:39838193G>A	uc010oiu.1	+	16	8589	c.8458G>A	c.(8458-8460)GAA>AAA	p.E2820K	MACF1_uc010ois.1_Missense_Mutation_p.E2318K|MACF1_uc001cda.1_Missense_Mutation_p.E2226K|MACF1_uc001cdc.1_Missense_Mutation_p.E1405K|MACF1_uc001cdb.1_Missense_Mutation_p.E1405K	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4385					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTGGTGGAAGAAATCAATTG	0.403													0	0	0	0.055883	0	22	59										A	39838193	G	A	39838193	3	1	108	1	0	0	0	0	1	0	0	0	9144	943	33	1	13289	1	MACF1	1	39838193	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	38210	39838193	209412428	5	32883										
STIL	6491	broad.mit.edu	37	chr1	47767248	47767248	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cgcacctttaaagctgaactGaagtcatctacactgtgaac	7	11	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:47767248G>A	uc001crc.1	-	5	593	c.438C>T	c.(436-438)TTC>TTT	p.F146F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Silent_p.F146F|STIL_uc010omo.1_Silent_p.F146F|STIL_uc001crd.1_Silent_p.F146F|STIL_uc001cre.1_Silent_p.F146F|STIL_uc001crg.1_Silent_p.F146F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	146					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AAGCTGAACTGAAGTCATCTA	0.348													0	0	0	0.139131	0	46	29										A	47767248	G	A	47767248	2	1	108	1	0	0	0	0	0	0	0	1	15281	1281	45	1		1	STIL	1	47767248	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	7929055	47767248	201483373	6	32884										
FOXE3	2301	broad.mit.edu	37	chr1	47882467	47882467	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atgttcgacaacggcagcttCctgcggcgccgcaagcgctt	12	14	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:47882467C>T	uc001crk.2	+	1	724	c.480C>T	c.(478-480)TTC>TTT	p.F160F		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	160	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		ACGGCAGCTTCCTGCGGCGCC	0.542													0	0	0	0.064281	0	35	21										T	47882467	C	T	47882467	2	4	108	1	0	0	0	0	0	0	0	1	6004	854	30	1		1	FOXE3	1	47882467	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	115219	47882467	201368154	7	32885										
INADL	10207	broad.mit.edu	37	chr1	62263087	62263087	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tctacttctccacttgaaccAccttcagacagaggtgatta	6	12	3	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:62263087A>G	uc001dab.2	+	11	1503	c.1389A>G	c.(1387-1389)CCA>CCG	p.P463P	INADL_uc009waf.1_Silent_p.P463P|INADL_uc001daa.2_Silent_p.P463P|INADL_uc001dad.3_Silent_p.P160P	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	463					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CACTTGAACCACCTTCAGACA	0.448													0	0	0	0.139131	0	122	58										G	62263087	A	G	62263087	2	3	108	1	0	0	0	0	0	0	0	1	7731	146	6	5		5	INADL	1	62263087	Silent	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	14380620	62263087	186987534	8	32886										
IL23R	149233	broad.mit.edu	37	chr1	67666436	67666436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taagtttagagacagaagaaGagcaacagtatctcacctca	8	8	2	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:67666436G>A	uc001ddo.2	+	5	593	c.508G>A	c.(508-510)GAG>AAG	p.E170K	IL23R_uc009waz.2_5'UTR|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Missense_Mutation_p.E127K|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Missense_Mutation_p.E15K|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Missense_Mutation_p.E29K|IL23R_uc010opp.1_RNA|IL23R_uc010opq.1_Missense_Mutation_p.E29K|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_Intron|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_5'UTR|IL23R_uc010opv.1_Missense_Mutation_p.E29K|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_5'UTR|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_5'UTR|IL23R_uc010oqb.1_Missense_Mutation_p.E29K|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_Intron|IL23R_uc010oqf.1_Intron|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	170	Extracellular (Potential).|Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						GACAGAAGAAGAGCAACAGTA	0.289													0	0	0	0.139131	0	54	29										A	67666436	G	A	67666436	3	1	108	1	0	0	0	0	1	0	0	0	7676	943	33	1	522	1	IL23R	1	67666436	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5403349	67666436	181584185	9	32887										
IL23R	149233	broad.mit.edu	37	chr1	67666498	67666498	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gattcattacaaggtggcaaGaagtacttggtttgggtcca	12	6	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:67666498G>A	uc001ddo.2	+	5	655	c.570G>A	c.(568-570)AAG>AAA	p.K190K	IL23R_uc009waz.2_5'UTR|IL23R_uc001ddp.2_RNA|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Intron|IL23R_uc010opk.1_Silent_p.K147K|IL23R_uc010opl.1_Intron|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Intron|IL23R_uc010opn.1_Silent_p.K35K|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Silent_p.K49K|IL23R_uc010opp.1_RNA|IL23R_uc010opq.1_Silent_p.K49K|IL23R_uc010opr.1_RNA|IL23R_uc010ops.1_5'UTR|IL23R_uc010opt.1_5'UTR|IL23R_uc010opu.1_5'UTR|IL23R_uc010opv.1_Silent_p.K49K|IL23R_uc010opw.1_Intron|IL23R_uc010opx.1_Intron|IL23R_uc010opy.1_5'UTR|IL23R_uc010opz.1_Intron|IL23R_uc010oqa.1_5'UTR|IL23R_uc010oqb.1_Silent_p.K49K|IL23R_uc010oqc.1_Intron|IL23R_uc010oqd.1_Intron|IL23R_uc010oqe.1_5'UTR|IL23R_uc010oqf.1_5'UTR|IL23R_uc010oqg.1_5'UTR|IL23R_uc010oqh.1_Intron	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	190	Extracellular (Potential).|Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						AAGGTGGCAAGAAGTACTTGG	0.373													0	0	0	0.139131	0	80	44										A	67666498	G	A	67666498	2	1	108	1	0	0	0	0	0	0	0	1	7676	933	33	1		1	IL23R	1	67666498	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	62	67666498	181584123	10	32888										
FUBP1	8880	broad.mit.edu	37	chr1	78429366	78429366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cttgacctctacctcttcctCgaccaccaggtccaggtcca	6	18	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:78429366C>T	uc001dii.2	-	13	1165	c.1076G>A	c.(1075-1077)CGA>CAA	p.R359Q	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.R380Q	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	359	Gly-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						ACCTCTTCCTCGACCACCAGG	0.428													0	0	0	0.0918	0	26	41										T	78429366	C	T	78429366	3	4	108	1	0	0	0	0	1	0	0	0	6092	884	31	1	890	1	FUBP1	1	78429366	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	10762868	78429366	170821255	11	32889										
COL11A1	1301	broad.mit.edu	37	chr1	103461433	103461433	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	attttaccttttcacctttaGatcccttgagacctctgaca	4	12	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:103461433G>C	uc001dul.2	-	28	2645	c.2327C>G	c.(2326-2328)TCT>TGT	p.S776C	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.S788C|COL11A1_uc001dun.2_Missense_Mutation_p.S737C|COL11A1_uc009weh.2_Missense_Mutation_p.S660C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	776	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTCACCTTTAGATCCCTTGAG	0.269													0	0	0	0.055883	0	18	119										C	103461433	G	C	103461433	3	2	108	1	0	0	0	0	1	0	0	0	3667	942	33	1	3253	1	COL11A1	1	103461433	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	25032067	103461433	145789188	12	32890										
COL11A1	1301	broad.mit.edu	37	chr1	103468019	103468019	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cccttgttgacctggaggccCaggctccccttggggaccct	12	16	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:103468019C>G	uc001dul.2	-	23	2380	c.2062G>C	c.(2062-2064)GGG>CGG	p.G688R	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G700R|COL11A1_uc001dun.2_Missense_Mutation_p.G649R|COL11A1_uc009weh.2_Missense_Mutation_p.G572R	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	688	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGAGGCCCAGGCTCCCCT	0.423													0	0	0	0.047766	0	7	7										G	103468019	C	G	103468019	3	3	108	1	0	0	0	0	1	0	0	0	3667	594	21	4	3538	4	COL11A1	1	103468019	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6586	103468019	145782602	13	32891										
ATXN7L2	127002	broad.mit.edu	37	chr1	110031674	110031674	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggtggctgctcccagcagcaCcttctctgttcgtgccaagc	11	15	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:110031674C>T	uc001dxr.2	+	7	1004	c.989C>T	c.(988-990)ACC>ATC	p.T330I	ATXN7L2_uc001dxs.2_5'UTR|ATXN7L2_uc001dxt.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	330										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCCAGCAGCACCTTCTCTGTT	0.617													0	0	0	0.139131	0	87	26										T	110031674	C	T	110031674	3	4	108	1	0	0	0	0	1	0	0	0	1217	507	18	2	1015	2	ATXN7L2	1	110031674	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6563655	110031674	139218947	14	32892										
KCNC4	3749	broad.mit.edu	37	chr1	110766110	110766110	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tttgccaccatgatctactaCgctgagcgcattggggccag	11	12	1	2	rs139324520		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:110766110C>T	uc001dzh.2	+	2	1260	c.1203C>T	c.(1201-1203)TAC>TAT	p.Y401Y	KCNC4_uc001dzf.2_Silent_p.Y401Y|KCNC4_uc009wfr.2_Silent_p.Y401Y|KCNC4_uc001dzg.2_Silent_p.Y401Y|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	401	Helical; Name=Segment S5; (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGATCTACTACGCTGAGCGCA	0.592													0	0	0	0.064281	0	35	120										T	110766110	C	T	110766110	2	4	108	1	0	0	0	0	0	0	0	1	8017	547	19	2		2	KCNC4	1	110766110	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	734436	110766110	138484511	15	32893										
PDZK1	5174	broad.mit.edu	37	chr1	145747150	145747150	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caccgagggccacctggtccGggtggttgagaagtgtagcc	16	11	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:145747150G>T	uc001eon.1	+	3	204	c.107G>T	c.(106-108)CGG>CTG	p.R36L	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.R36L|PDZK1_uc010oza.1_Missense_Mutation_p.R36L	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	36	PDZ 1.				carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CACCTGGTCCGGGTGGTTGAG	0.502													1	0	1.10923e-09	0.076483	1.16626e-09	22	491										T	145747150	G	T	145747150	3	4	108	1	0	0	0	0	1	0	0	0	11707	1116	39	4	109	4	PDZK1	1	145747150	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	34981040	145747150	103503471	16	32894										
BCL9	607	broad.mit.edu	37	chr1	147095710	147095710	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtggttccgatgccaaccctCagcccaatgggaatgaccca	10	14	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:147095710C>T	uc001epq.2	+	10	3971	c.3231C>T	c.(3229-3231)CTC>CTT	p.L1077L	BCL9_uc010ozr.1_Silent_p.L991L	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1077	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					TGCCAACCCTCAGCCCAATGG	0.493			T	IGH@|IGL@	B-ALL								0	0	0	0.139131	0	104	219										T	147095710	C	T	147095710	2	4	108	1	0	0	0	0	0	0	0	1	1381	813	29	1		1	BCL9	1	147095710	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1348560	147095710	102154911	17	32895										
IQGAP3	128239	broad.mit.edu	37	chr1	156530742	156530743	+	Frame_Shift_Ins	INS	-	-	C													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tactggcttgttcctgatcaINSccctttgtgttggctgcagc							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:156530742_156530743insC	uc001fpf.2	-	11	1187_1188	c.1112_1113insG	c.(1111-1113)GGTfs	p.G371fs	IQGAP3_uc009wsb.1_Frame_Shift_Ins_p.G328fs	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	371					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTTCCTGATCACCCTTTGTGTT	0.525																		7	113	---	---								C	156530743	-	C	156530742	7	5	108	1	0	1	1	0	0	0	0	0	7816	146	6	0	3894	0	IQGAP3	1	156530742	Frame_Shift_Ins	INS	-	TCGA-GC-A3YS-01A-11D-A23M-08	9435032	156530742	92719879	18	32896										
SH2D2A	9047	broad.mit.edu	37	chr1	156777073	156777073	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tccaggcgggtgggggctggTggggcaggggagggccttgc	24	8	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:156777073T>G	uc001fqd.2	-	8	1207	c.1067A>C	c.(1066-1068)CAC>CCC	p.H356P	SH2D2A_uc001fqc.1_Missense_Mutation_p.H328P|SH2D2A_uc009wsh.2_Missense_Mutation_p.H366P|SH2D2A_uc001fqe.2_Missense_Mutation_p.H338P|SH2D2A_uc010phs.1_Missense_Mutation_p.H356P	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	356	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGGCTGGTGGGGCAGGGG	0.597													0	0	0	0.080935	0	5	22										G	156777073	T	G	156777073	3	3	108	1	0	0	0	0	1	0	0	0	14232	1696	59	5	106	5	SH2D2A	1	156777073	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	246331	156777073	92473548	19	32897										
SERPINC1	462	broad.mit.edu	37	chr1	173881128	173881128	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gatctgatcagatgttttctCagatatggtgtcaaacttaa	8	6	4	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:173881128C>G	uc001gjt.2	-	3	552	c.433G>C	c.(433-435)GAG>CAG	p.E145Q		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	145					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	GATGTTTTCTCAGATATGGTG	0.433													0	0	0	0.09836	0	43	115										G	173881128	C	G	173881128	3	3	108	1	0	0	0	0	1	0	0	0	14109	835	29	1	981	1	SERPINC1	1	173881128	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	17104055	173881128	75369493	20	32898										
PPP1R12B	4660	broad.mit.edu	37	chr1	202549682	202549682	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agagtcatcagcaaactgtcCaagtaggctaggctccagat	10	10	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:202549682C>G	uc001gya.1	+	24	3087	c.2943C>G	c.(2941-2943)TCC>TCG	p.S981S	PPP1R12B_uc001gxz.1_3'UTR|PPP1R12B_uc001gyb.1_3'UTR|PPP1R12B_uc001gyc.1_Silent_p.S207S	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	981					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAAACTGTCCAAGTAGGCTA	0.478													0	0	0	0.104719	0	44	28										G	202549682	C	G	202549682	2	3	108	1	0	0	0	0	0	0	0	1	12355	581	21	4		4	PPP1R12B	1	202549682	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	28668554	202549682	46700939	21	32899										
ZC3H11A	9877	broad.mit.edu	37	chr1	203798669	203798669	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caaattgtctgtccagtccaAtccttcccctcagctgcgga	7	15	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:203798669A>G	uc001hac.2	+	8	1005	c.389A>G	c.(388-390)AAT>AGT	p.N130S	ZC3H11A_uc001had.2_Missense_Mutation_p.N130S|ZC3H11A_uc001hae.2_Missense_Mutation_p.N130S|ZC3H11A_uc001haf.2_Missense_Mutation_p.N130S|ZC3H11A_uc010pqm.1_Missense_Mutation_p.N76S|ZC3H11A_uc001hag.1_Missense_Mutation_p.N130S	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	130							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GTCCAGTCCAATCCTTCCCCT	0.483													0	0	0	0.139131	0	121	55										G	203798669	A	G	203798669	3	3	108	1	0	0	0	0	1	0	0	0	17557	101	4	5	403	5	ZC3H11A	1	203798669	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	1248987	203798669	45451952	22	32900										
CENPF	1063	broad.mit.edu	37	chr1	214825065	214825065	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgtttaggatcaattgaagGagctcacactagaaaatagt	9	6	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:214825065G>C	uc001hkm.2	+	15	8170	c.7996G>C	c.(7996-7998)GAG>CAG	p.E2666Q		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2762	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TCAATTGAAGGAGCTCACACT	0.348													0	0	0	0.117977	0	46	20										C	214825065	G	C	214825065	3	2	108	1	0	0	0	0	1	0	0	0	3231	1175	41	1	8050	1	CENPF	1	214825065	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	11026396	214825065	34425556	23	32901										
TMEM63A	9725	broad.mit.edu	37	chr1	226055673	226055673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aacaggaagatgatgtgcctCtggaaggacaggtagtggat	15	5	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:226055673C>T	uc001hpm.1	-	7	679	c.429G>A	c.(427-429)CAG>CAA	p.Q143Q	TMEM63A_uc010pvi.1_Silent_p.Q143Q	NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	143						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					TGATGTGCCTCTGGAAGGACA	0.542													0	0	0	0.139131	0	52	46										T	226055673	C	T	226055673	2	4	108	1	0	0	0	0	0	0	0	1	16187	912	32	1		1	TMEM63A	1	226055673	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	11230608	226055673	23194948	24	32902										
ZNF678	339500	broad.mit.edu	37	chr1	227842637	227842637	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aaaccttacacaacataagaGaattcatactggagagaaac	6	8	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:227842637G>C	uc001hqw.1	+	4	1031	c.686G>C	c.(685-687)AGA>ACA	p.R229T	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	284					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)				CAACATAAGAGAATTCATACT	0.378													0	0	0	0.086207	0	41	221										C	227842637	G	C	227842637	3	2	108	1	0	0	0	0	1	0	0	0	18082	942	33	1	865	1	ZNF678	1	227842637	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1786964	227842637	21407984	25	32903										
OBSCN	84033	broad.mit.edu	37	chr1	228399583	228399583	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gccaccctcagctgccagatCgtgggtaatcccacgccaca	9	17	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:228399583C>T	uc009xez.1	+	2	143	c.99C>T	c.(97-99)ATC>ATT	p.I33I	OBSCN_uc001hsn.2_Silent_p.I33I|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	33	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCTGCCAGATCGTGGGTAATC	0.692													0	0	0	0.02938	0	7	18										T	228399583	C	T	228399583	2	4	108	1	0	0	0	0	0	0	0	1	10812	874	31	1		1	OBSCN	1	228399583	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	556946	228399583	20851038	26	32904										
SIPA1L2	57568	broad.mit.edu	37	chr1	232574863	232574863	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtggggcttacctggaatgaGaggatatctcactgagatcg	14	7	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:232574863G>C	uc001hvg.2	-	13	4180	c.4022C>G	c.(4021-4023)TCT>TGT	p.S1341C	SIPA1L2_uc001hvf.2_Missense_Mutation_p.S415C	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1341	Ser-rich.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCTGGAATGAGAGGATATCTC	0.582													0	0	0	0.043863	0	19	76										C	232574863	G	C	232574863	3	2	108	1	0	0	0	0	1	0	0	0	14330	942	33	1	1182	1	SIPA1L2	1	232574863	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4175280	232574863	16675758	27	32905										
LYST	1130	broad.mit.edu	37	chr1	235969730	235969730	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acgcataaaaaagccacacaGaggaataggtttattgtgtt	9	6	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:235969730G>C	uc001hxj.2	-	6	2881	c.2706C>G	c.(2704-2706)CTC>CTG	p.L902L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.L902L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	902					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAGCCACACAGAGGAATAGGT	0.438									Chediak-Higashi_syndrome				0	0	0	0.139131	0	68	187										C	235969730	G	C	235969730	2	2	108	1	0	0	0	0	0	0	0	1	9128	929	33	1		1	LYST	1	235969730	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	3394867	235969730	13280891	28	32906										
RYR2	6262	broad.mit.edu	37	chr1	237794757	237794757	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aataacaaagtgttttaccaGcaccctaatctcatgagggc	7	10	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:237794757G>A	uc001hyl.1	+	42	6591	c.6471G>A	c.(6469-6471)CAG>CAA	p.Q2157Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2157	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGTTTTACCAGCACCCTAATC	0.448													0	0	0	0.069456	0	33	28										A	237794757	G	A	237794757	2	1	108	1	0	0	0	0	0	0	0	1	13769	962	34	2		2	RYR2	1	237794757	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1825027	237794757	11455864	29	32907										
ZNF672	79894	broad.mit.edu	37	chr1	249142042	249142042	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	catccacgtgtcccggagccCcacgcgaccccgtgtctcag	10	19	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr1:249142042C>G	uc001iex.2	+	4	1264	c.569C>G	c.(568-570)CCC>CGC	p.P190R		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			TCCCGGAGCCCCACGCGACCC	0.716													0	0	0	0.02938	0	6	17										G	249142042	C	G	249142042	3	3	108	1	0	0	0	0	1	0	0	0	18076	623	22	4	571	4	ZNF672	1	249142042	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	11347285	249142042	108579	30	32908										
ZFP36L2	678	broad.mit.edu	37	chr2	43452168	43452168	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cgacgggaagcccgagaagcTgaggctgtggtgcaacttgg	17	9	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:43452168T>C	uc002rsv.3	-	2	1066	c.775A>G	c.(775-777)AGC>GGC	p.S259G	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	259					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CCCGAGAAGCTGAGGCTGTGG	0.682													0	0	0	0.038147	0	7	12										C	43452168	T	C	43452168	3	2	108	1	0	0	0	0	1	0	0	0	17644	1580	55	5	713	5	ZFP36L2	2	43452168	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08		43452168	199747205	31	32909										
DUSP11	8446	broad.mit.edu	37	chr2	73993695	73993695	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgagtcttcaaaatcacttGacctgggtacactggaattc	8	10	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:73993695G>C	uc002sjp.2	-	8	827	c.785C>G	c.(784-786)TCA>TGA	p.S262*		NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	215					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						AAAATCACTTGACCTGGGTAC	0.378													0	0	0	0.139131	0	74	43										C	73993695	G	C	73993695	4	2	108	1	0	0	0	0	0	1	0	0	4811	1294	45	1	356	1	DUSP11	2	73993695	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	30541527	73993695	169205678	32	32910										
SUCLG1	8802	broad.mit.edu	37	chr2	84670479	84670479	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccctggagtggttcctccaaCgagtttggtgccatattcca	10	12	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:84670479C>T	uc002son.2	-	3	440	c.247G>A	c.(247-249)GTT>ATT	p.V83I	SUCLG1_uc010ysk.1_Missense_Mutation_p.V70I	NM_003849	NP_003840	P53597	SUCA_HUMAN	succinate-CoA ligase, GDP-forming alpha subunit	83					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)	GTTCCTCCAACGAGTTTGGTG	0.498													0	0	0	0.139131	0	47	29										T	84670479	C	T	84670479	3	4	108	1	0	0	0	0	1	0	0	0	15363	536	19	2	821	2	SUCLG1	2	84670479	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	10676784	84670479	158528894	33	32911										
AFF3	3899	broad.mit.edu	37	chr2	100209756	100209756	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tccttggtggcaggggcgctCaatacccctggctcctgggg	15	13	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:100209756C>G	uc002tag.2	-	14	2603	c.2367G>C	c.(2365-2367)TTG>TTC	p.L789F	AFF3_uc002taf.2_Missense_Mutation_p.L814F|AFF3_uc010fiq.1_Missense_Mutation_p.L789F|AFF3_uc010yvr.1_Missense_Mutation_p.L942F|AFF3_uc002tah.1_Missense_Mutation_p.L814F	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	789					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CAGGGGCGCTCAATACCCCTG	0.577													0	0	0	0.069288	0	22	40										G	100209756	C	G	100209756	3	3	108	1	0	0	0	0	1	0	0	0	358	825	29	1	1357	1	AFF3	2	100209756	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	15539277	100209756	142989617	34	32912										
SLC5A7	60482	broad.mit.edu	37	chr2	108626840	108626840	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gttatcttcccccagctgctTtgtgtactctttgttaaggg	9	10	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:108626840T>C	uc002tdv.2	+	9	1542	c.1266T>C	c.(1264-1266)CTT>CTC	p.L422L	SLC5A7_uc010ywm.1_Silent_p.L175L|SLC5A7_uc010fjj.2_Silent_p.L422L|SLC5A7_uc010ywn.1_Silent_p.L309L	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	422	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CCCAGCTGCTTTGTGTACTCT	0.498													0	0	0	0.139131	0	53	45										C	108626840	T	C	108626840	2	2	108	1	0	0	0	0	0	0	0	1	14670	1828	64	5		5	SLC5A7	2	108626840	Silent	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	8417084	108626840	134572533	35	32913										
IWS1	55677	broad.mit.edu	37	chr2	128253576	128253576	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agaagcgacccagctcacctCagcagcttcattcatcttga	7	14	5	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:128253576C>G	uc002ton.2	-	7	2017	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q	IWS1_uc010yzl.1_RNA	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	572					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		CAGCTCACCTCAGCAGCTTCA	0.468													0	0	0	0.139131	0	119	85										G	128253576	C	G	128253576	3	3	108	1	0	0	0	0	1	0	0	0	7931	835	29	1	777	1	IWS1	2	128253576	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	19626736	128253576	114945797	36	32914										
XIRP2	129446	broad.mit.edu	37	chr2	168100730	168100730	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acttgaagaagttgacagagGagatgtgaagaattacacac	11	5	0	7			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:168100730G>C	uc002udx.2	+	8	2846	c.2828G>C	c.(2827-2829)GGA>GCA	p.G943A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G768A|XIRP2_uc010fpq.2_Missense_Mutation_p.G721A|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	768	Xin 12.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTTGACAGAGGAGATGTGAAG	0.343													0	0	0	0.134883	0	32	36										C	168100730	G	C	168100730	3	2	108	1	0	0	0	0	1	0	0	0	17427	1174	41	1	2858	1	XIRP2	2	168100730	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	39847154	168100730	75098643	37	32915										
MYO3B	140469	broad.mit.edu	37	chr2	171356164	171356164	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtctcgtttcaggtttttctCaaatattaccatgttgagca	7	8	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:171356164C>G	uc002ufy.2	+	27	3278	c.3135C>G	c.(3133-3135)CTC>CTG	p.L1045L	MYO3B_uc002ufv.2_Silent_p.L1032L|MYO3B_uc010fqb.1_Silent_p.L1032L|MYO3B_uc002ufz.2_Silent_p.L1045L|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1045	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AGGTTTTTCTCAAATATTACC	0.388													0	0	0	0.069234	0	9	60										G	171356164	C	G	171356164	2	3	108	1	0	0	0	0	0	0	0	1	10077	813	29	1		1	MYO3B	2	171356164	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3255434	171356164	71843209	38	32916										
INO80D	54891	broad.mit.edu	37	chr2	206869542	206869542	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tttaccacgcctccaagtggCacctcaagttgggttgggag	12	11	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:206869542C>T	uc002vaz.3	-	11	3039	c.2634G>A	c.(2632-2634)GTG>GTA	p.V878V		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTCCAAGTGGCACCTCAAGTT	0.547													0	0	0	0.055883	0	21	35										T	206869542	C	T	206869542	2	4	108	1	0	0	0	0	0	0	0	1	7749	697	25	2		2	INO80D	2	206869542	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	35513378	206869542	36329831	39	32917										
INPP5D	3635	broad.mit.edu	37	chr2	234079249	234079249	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cagaaggtcttcctacacttCggtaagagcagcaaccccgg	10	13	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:234079249C>T	uc010zmo.1	+	15	2052	c.1899C>T	c.(1897-1899)TTC>TTT	p.F633F	INPP5D_uc010zmp.1_Silent_p.F632F	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	633					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCTACACTTCGGTAAGAGCA	0.323													0	0	0	0.132662	0	16	18										T	234079249	C	T	234079249	2	4	108	1	0	0	0	0	0	0	0	1	7756	898	31	1		1	INPP5D	2	234079249	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	27209707	234079249	9120124	40	32918										
COL6A3	1293	broad.mit.edu	37	chr2	238277740	238277740	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aatcctgctaacaaaatctcGaatatgtgcaaagccatctg	6	10	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr2:238277740G>A	uc002vwl.2	-	10	4651	c.4366C>T	c.(4366-4368)CGA>TGA	p.R1456*	COL6A3_uc002vwo.2_Nonsense_Mutation_p.R1250*|COL6A3_uc010znj.1_Nonsense_Mutation_p.R849*	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1456	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACAAAATCTCGAATATGTGCA	0.458													0	0	0	0.055883	0	21	15										A	238277740	G	A	238277740	4	1	108	1	0	0	0	0	0	1	0	0	3701	1066	37	1	5307	1	COL6A3	2	238277740	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4198491	238277740	4921633	41	32919										
PLCL2	23228	broad.mit.edu	37	chr3	17051752	17051752	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctcaatcctggtttaaaaaCgagcaaaattgagcttaagt	7	8	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:17051752C>T	uc011awc.1	+	5	995	c.890C>T	c.(889-891)ACG>ATG	p.T297M	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Missense_Mutation_p.T179M	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	305					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GGTTTAAAAACGAGCAAAATT	0.348													0	0	0	0.125774	0	30	83										T	17051752	C	T	17051752	3	4	108	1	0	0	0	0	1	0	0	0	12040	536	19	2	914	2	PLCL2	3	17051752	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		17051752	180970678	42	32920										
NKTR	4820	broad.mit.edu	37	chr3	42679721	42679721	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taataaacaagaaaaaaacaGaggtgaagaaaaatccaagt	7	4	0	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:42679721G>C	uc003clo.2	+	13	2672	c.2525G>C	c.(2524-2526)AGA>ACA	p.R842T	NKTR_uc003clm.1_Missense_Mutation_p.R589T|NKTR_uc003clp.2_Missense_Mutation_p.R589T|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R732T|NKTR_uc003clr.1_Missense_Mutation_p.R589T|NKTR_uc003cls.2_Missense_Mutation_p.R542T	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	842					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GAAAAAAACAGAGGTGAAGAA	0.413													0	0	0	0.146539	0	14	50										C	42679721	G	C	42679721	3	2	108	1	0	0	0	0	1	0	0	0	10448	942	33	1	2571	1	NKTR	3	42679721	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	25627969	42679721	155342709	43	32921										
BSN	8927	broad.mit.edu	37	chr3	49698687	49698687	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccctttttccagtccccgctGatagccgtgccccactgcag	8	18	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:49698687G>A	uc003cxe.3	+	6	9523	c.9409G>A	c.(9409-9411)GAT>AAT	p.D3137N		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3137					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGTCCCCGCTGATAGCCGTGC	0.622													0	0	0	0.038395	0	15	44										A	49698687	G	A	49698687	3	1	108	1	0	0	0	0	1	0	0	0	1530	1290	45	1	9431	1	BSN	3	49698687	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	7018966	49698687	148323743	44	32922										
IP6K1	9807	broad.mit.edu	37	chr3	49770248	49770248	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gagctttcggtccttggactCggagcgcatgcggctcagct	14	12	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:49770248C>T	uc003cxm.1	-	4	907	c.592G>A	c.(592-594)GAG>AAG	p.E198K	IP6K1_uc003cxn.1_Missense_Mutation_p.E33K|IP6K1_uc011bcv.1_Missense_Mutation_p.E33K|IP6K1_uc003cxo.2_Missense_Mutation_p.E198K	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	198					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						TCCTTGGACTCGGAGCGCATG	0.567													0	0	0	0.038395	0	18	44										T	49770248	C	T	49770248	3	4	108	1	0	0	0	0	1	0	0	0	7788	893	31	1	745	1	IP6K1	3	49770248	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	71561	49770248	148252182	45	32923										
ADAMTS9	56999	broad.mit.edu	37	chr3	64607948	64607948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctgaggtttatcttcaattGgaatattgaaagaatagcgt	10	4	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:64607948G>A	uc003dmg.2	-	18	2644	c.2612C>T	c.(2611-2613)CCA>CTA	p.P871L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.P843L|ADAMTS9_uc003dmh.1_Missense_Mutation_p.P700L|ADAMTS9_uc003dmk.1_Missense_Mutation_p.P871L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	871	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ATCTTCAATTGGAATATTGAA	0.438													0	0	0	0.038395	0	18	47										A	64607948	G	A	64607948	3	1	108	1	0	0	0	0	1	0	0	0	273	1348	47	2	3283	2	ADAMTS9	3	64607948	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	14837700	64607948	133414482	46	32924										
TOMM70A	9868	broad.mit.edu	37	chr3	100105732	100105732	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agggcacaagctaatagcctCagtatagcactgaatagctt	9	9	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:100105732C>T	uc003dtw.2	-	2	847	c.415G>A	c.(415-417)GAG>AAG	p.E139K		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	139	TPR 1.|Cytoplasmic (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						CTAATAGCCTCAGTATAGCAC	0.383													0	0	0	0.069288	0	24	103										T	100105732	C	T	100105732	3	4	108	1	0	0	0	0	1	0	0	0	16359	835	29	1	1455	1	TOMM70A	3	100105732	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	35497784	100105732	97916698	47	32925										
ARHGAP31	57514	broad.mit.edu	37	chr3	119134233	119134233	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctcatcttactgtaaagcaGacccctggagggtttactcc	8	13	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:119134233G>C	uc003ecj.3	+	12	3989	c.3457G>C	c.(3457-3459)GAC>CAC	p.D1153H		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1153					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						CTGTAAAGCAGACCCCTGGAG	0.537													0	0	0	0.105934	0	14	63										C	119134233	G	C	119134233	3	2	108	1	0	0	0	0	1	0	0	0	880	942	33	1	3503	1	ARHGAP31	3	119134233	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	19028501	119134233	78888197	48	32926										
PLS1	5357	broad.mit.edu	37	chr3	142403175	142403175	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggaattactgctgcgatggGtgaactaccatctgaccaat	10	9	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:142403175G>T	uc010huv.2	+	8	985	c.826G>T	c.(826-828)GTG>TTG	p.V276L	PLS1_uc003euz.2_Missense_Mutation_p.V276L|PLS1_uc003eva.2_Missense_Mutation_p.V276L	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	276	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						GCTGCGATGGGTGAACTACCA	0.413													1	0	5.39261e-20	0.139131	5.83486e-20	56	53										T	142403175	G	T	142403175	3	4	108	1	0	0	0	0	1	0	0	0	12107	1261	44	4	852	4	PLS1	3	142403175	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	23268942	142403175	55619255	49	32927										
MED12L	116931	broad.mit.edu	37	chr3	151112453	151112453	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgcttttgtaggtggctccaGattggaccctgcaggctcct	12	11	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:151112453G>C	uc003eyp.2	+	37	5551	c.5513G>C	c.(5512-5514)AGA>ACA	p.R1838T	MED12L_uc011bnz.1_Missense_Mutation_p.R1698T	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1838					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTGGCTCCAGATTGGACCCT	0.463													0	0	0	0.11126	0	39	156										C	151112453	G	C	151112453	3	2	108	1	0	0	0	0	1	0	0	0	9429	942	33	1	5659	1	MED12L	3	151112453	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	8709278	151112453	46909977	50	32928										
RTP2	344892	broad.mit.edu	37	chr3	187419823	187419823	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	actgggcttgaggttggggtCtatgatgagctcccagctgt	15	8	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:187419823C>T	uc003fro.1	-	1	523	c.94G>A	c.(94-96)GAC>AAC	p.D32N		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	32	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGGTTGGGGTCTATGATGAGC	0.577													0	0	0	0.092188	0	38	181										T	187419823	C	T	187419823	3	4	108	1	0	0	0	0	1	0	0	0	13734	913	32	1	591	1	RTP2	3	187419823	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	36307370	187419823	10602607	51	32929										
SENP5	205564	broad.mit.edu	37	chr3	196612107	196612107	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaatccacttagccttttctGagaaatggaatactgggttt	9	7	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr3:196612107G>C	uc003fwz.3	+	2	304	c.55G>C	c.(55-57)GAG>CAG	p.E19Q	SENP5_uc011bty.1_Missense_Mutation_p.E19Q	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	19					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGCCTTTTCTGAGAAATGGAA	0.383													0	0	0	0.076483	0	24	76										C	196612107	G	C	196612107	3	2	108	1	0	0	0	0	1	0	0	0	14049	1291	45	1	57	1	SENP5	3	196612107	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	9192284	196612107	1410323	52	32930										
LIMCH1	22998	broad.mit.edu	37	chr4	41668680	41668680	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atttgccaaatctcaattctCaaggtaaagaggacatgttt	7	7	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:41668680C>G	uc003gvu.3	+	16	2293	c.2239C>G	c.(2239-2241)CAA>GAA	p.Q747E	LIMCH1_uc003gvv.3_Missense_Mutation_p.Q747E|LIMCH1_uc003gvw.3_Missense_Mutation_p.Q747E|LIMCH1_uc003gvx.3_Missense_Mutation_p.Q735E|LIMCH1_uc003gwe.3_Intron|LIMCH1_uc003gvy.3_Missense_Mutation_p.Q576E|LIMCH1_uc003gwa.3_Missense_Mutation_p.Q588E|LIMCH1_uc003gvz.3_Missense_Mutation_p.Q1132E|LIMCH1_uc011byu.1_Missense_Mutation_p.Q581E|LIMCH1_uc003gwc.3_Missense_Mutation_p.Q593E|LIMCH1_uc003gwd.3_Missense_Mutation_p.Q581E|LIMCH1_uc011byv.1_Missense_Mutation_p.Q498E|LIMCH1_uc011byw.1_Missense_Mutation_p.Q47E	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	747					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TCTCAATTCTCAAGGTAAAGA	0.393													0	0	0	0.058154	0	9	40										G	41668680	C	G	41668680	3	3	108	1	0	0	0	0	1	0	0	0	8797	827	29	1	2329	1	LIMCH1	4	41668680	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		41668680	149485596	53	32931										
GABRG1	2565	broad.mit.edu	37	chr4	46099350	46099350	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taaatcctcatcatcttcatCatctgccttatcaacactaa	1	13	7	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:46099350C>T	uc003gxb.2	-	2	273	c.121G>A	c.(121-123)GAT>AAT	p.D41N		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	41	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TCATCTTCATCATCTGCCTTA	0.328													0	0	0	0.139131	0	60	58										T	46099350	C	T	46099350	3	4	108	1	0	0	0	0	1	0	0	0	6171	826	29	1	1308	1	GABRG1	4	46099350	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	4430670	46099350	145054926	54	32932										
PRKG2	5593	broad.mit.edu	37	chr4	82126175	82126175	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccatctgggtgcttagaatgTttaggtttcactgaaccatt	9	8	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:82126175T>C	uc003hmh.2	-	1	41	c.27A>G	c.(25-27)AAA>AAG	p.K9K	PRKG2_uc011cch.1_Silent_p.K9K	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	9					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GCTTAGAATGTTTAGGTTTCA	0.502													0	0	0	0.058154	0	10	40										C	82126175	T	C	82126175	2	2	108	1	0	0	0	0	0	0	0	1	12523	1722	60	5		5	PRKG2	4	82126175	Silent	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	36026825	82126175	109028101	55	32933										
ANK2	287	broad.mit.edu	37	chr4	114251565	114251565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caacaatgcctccaatggtgGaaggagaaggcctggccagt	13	10	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:114251565G>A	uc003ibe.3	+	27	3164	c.3064G>A	c.(3064-3066)GAA>AAA	p.E1022K	ANK2_uc003ibd.3_Missense_Mutation_p.E1013K|ANK2_uc003ibf.3_Missense_Mutation_p.E1022K|ANK2_uc011cgc.1_Missense_Mutation_p.E231K|ANK2_uc003ibg.3_Missense_Mutation_p.E50K|ANK2_uc003ibc.2_Missense_Mutation_p.E998K|ANK2_uc011cgb.1_Missense_Mutation_p.E1037K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCCAATGGTGGAAGGAGAAGG	0.537													0	0	0	0.09836	0	39	17										A	114251565	G	A	114251565	3	1	108	1	0	0	0	0	1	0	0	0	621	1175	41	1	3235	1	ANK2	4	114251565	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	32125390	114251565	76902711	56	32934										
EDNRA	1909	broad.mit.edu	37	chr4	148406959	148406959	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gatttcaccacttttcgtggCacagagctcagcttcctggt	9	12	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:148406959C>A	uc003iky.2	+	2	818	c.126C>A	c.(124-126)GGC>GGA	p.G42G	EDNRA_uc011cid.1_Intron|EDNRA_uc010ipe.1_Silent_p.G42G|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Silent_p.G42G	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	42	Extracellular (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CTTTTCGTGGCACAGAGCTCA	0.448													1	0	4.54149e-19	0.069288	4.90097e-19	24	123										A	148406959	C	A	148406959	2	1	108	1	0	0	0	0	0	0	0	1	4919	697	25	4		4	EDNRA	4	148406959	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	34155394	148406959	42747317	57	32935										
KIAA0922	23240	broad.mit.edu	37	chr4	154544213	154544213	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gataagaagcccatggtggaCgcccagcacttcctgccggc	12	14	0	1	rs140734056	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr4:154544213C>T	uc003inm.3	+	29	4072	c.4020C>T	c.(4018-4020)GAC>GAT	p.D1340D	KIAA0922_uc010ipp.2_Silent_p.D1341D|KIAA0922_uc010ipq.2_Silent_p.D1109D	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1340	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CCATGGTGGACGCCCAGCACT	0.682													0	0	0	0.047766	0	8	57										T	154544213	C	T	154544213	2	4	108	1	0	0	0	0	0	0	0	1	8201	535	19	2		2	KIAA0922	4	154544213	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6137254	154544213	36610063	58	32936										
EXOC3	11336	broad.mit.edu	37	chr5	464494	464494	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	accgtggaagactatttcaaCgattttgccaaaattaaaaa	6	7	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:464494C>T	uc003jba.2	+	10	1871	c.1743C>T	c.(1741-1743)AAC>AAT	p.N581N		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	592					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACTATTTCAACGATTTTGCCA	0.443													0	0	0	0.049695	0	19	209										T	464494	C	T	464494	2	4	108	1	0	0	0	0	0	0	0	1	5303	535	19	2		2	EXOC3	5	464494	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		464494	180450766	59	32937										
NDUFS6	4726	broad.mit.edu	37	chr5	1801637	1801637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gggtgcgggtctcgccgaccGgggagaaggtcacgcacact	17	12	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:1801637G>A	uc003jcy.2	+	1	129	c.106G>A	c.(106-108)GGG>AGG	p.G36R	MRPL36_uc003jcx.3_5'Flank	NM_004553	NP_004544	O75380	NDUS6_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 6,	36					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1					NADH(DB00157)	CTCGCCGACCGGGGAGAAGGT	0.721													0	0	0	0.069234	0	11	9										A	1801637	G	A	1801637	3	1	108	1	0	0	0	0	1	0	0	0	10296	1116	39	2	108	2	NDUFS6	5	1801637	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1337143	1801637	179113623	60	32938										
ADCY2	108	broad.mit.edu	37	chr5	7520895	7520895	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttcgtggtgtacaccatgctGcccttcaacatgcgagacgc	10	13	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:7520895G>A	uc003jdz.1	+	3	520	c.453G>A	c.(451-453)CTG>CTA	p.L151L		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	151	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						ACACCATGCTGCCCTTCAACA	0.522													0	0	0	0.045705	0	32	150										A	7520895	G	A	7520895	2	1	108	1	0	0	0	0	0	0	0	1	294	1306	46	2		2	ADCY2	5	7520895	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5719258	7520895	173394365	61	32939										
CDH10	1008	broad.mit.edu	37	chr5	24509787	24509787	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggaggacctactaaaaacagGaggttcatccacatcttcta	8	10	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:24509787G>C	uc003jgr.1	-	7	1476	c.1144C>G	c.(1144-1146)CCT>GCT	p.P382A	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	382	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		CTAAAAACAGGAGGTTCATCC	0.393										HNSCC(23;0.051)			0	0	0	0.0333	0	17	124										C	24509787	G	C	24509787	3	2	108	1	0	0	0	0	1	0	0	0	3096	1174	41	1	1246	1	CDH10	5	24509787	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	16988892	24509787	156405473	62	32940										
ADAMTS12	81792	broad.mit.edu	37	chr5	33614470	33614470	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttgatgccagggttagtcacCtggaatagaagctaaaaggc	12	7	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:33614470C>G	uc003jia.1	-	16	2563	c.2400G>C	c.(2398-2400)CAG>CAC	p.Q800H	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q715H	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	800	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGTTAGTCACCTGGAATAGAA	0.438										HNSCC(64;0.19)			0	0	0	0.038147	0	6	90										G	33614470	C	G	33614470	3	3	108	1	0	0	0	0	1	0	0	0	257	680	24	4	2420	4	ADAMTS12	5	33614470	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	9104683	33614470	147300790	63	32941										
CAPSL	133690	broad.mit.edu	37	chr5	35910153	35910153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aaaagcttgcatgattacctCttttctggctctggacattg	8	9	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:35910153C>G	uc003jjt.1	-	4	435	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	CAPSL_uc003jju.1_Missense_Mutation_p.E114Q	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	114	EF-hand 3.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			ATGATTACCTCTTTTCTGGCT	0.353													0	0	0	0.139131	0	55	144										G	35910153	C	G	35910153	3	3	108	1	0	0	0	0	1	0	0	0	2639	922	32	1	294	1	CAPSL	5	35910153	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2295683	35910153	145005107	64	32942										
EGFLAM	133584	broad.mit.edu	37	chr5	38435313	38435313	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aattatgatgatgtgaagaaGaactcgggtgtcctgaagcc	12	6	0	6			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:38435313G>C	uc003jlc.1	+	16	2565	c.2241G>C	c.(2239-2241)AAG>AAC	p.K747N	EGFLAM_uc003jlb.1_Missense_Mutation_p.K747N|EGFLAM_uc003jle.1_Missense_Mutation_p.K513N|EGFLAM_uc003jlf.1_Missense_Mutation_p.K113N	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	747	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ATGTGAAGAAGAACTCGGGTG	0.463													0	0	0	0.125774	0	30	113										C	38435313	G	C	38435313	3	2	108	1	0	0	0	0	1	0	0	0	4966	933	33	1	2317	1	EGFLAM	5	38435313	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	2525160	38435313	142479947	65	32943										
ZNF131	7690	broad.mit.edu	37	chr5	43122240	43122240	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	accgattgaatgaacagcgaGagcaggaccggtttactgac	12	9	0	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:43122240G>C	uc011cpw.1	+	2	121	c.85G>C	c.(85-87)GAG>CAG	p.E29Q	ZNF131_uc010ivl.1_Missense_Mutation_p.E29Q|ZNF131_uc003jnj.3_5'UTR|ZNF131_uc003jnk.2_Missense_Mutation_p.E29Q|ZNF131_uc003jnn.3_5'UTR|ZNF131_uc003jnl.1_RNA|ZNF131_uc010ivm.1_RNA|ZNF131_uc003jnm.2_Missense_Mutation_p.E29Q	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	29						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGAACAGCGAGAGCAGGACCG	0.517													0	0	0	0.139131	0	89	88										C	43122240	G	C	43122240	3	2	108	1	0	0	0	0	1	0	0	0	17718	943	33	1	87	1	ZNF131	5	43122240	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4686927	43122240	137793020	66	32944										
POLK	51426	broad.mit.edu	37	chr5	74877153	74877153	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atcctttccaagtgaactttGaagaacaaaacaatcctcaa	4	10	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74877153G>A	uc003kdw.2	+	7	910	c.814G>A	c.(814-816)GAA>AAA	p.E272K	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003kea.2_Missense_Mutation_p.E272K|POLK_uc003keb.2_Missense_Mutation_p.E272K|POLK_uc010izq.2_Missense_Mutation_p.E272K|POLK_uc003kec.2_Missense_Mutation_p.E182K|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.E182K|POLK_uc003kee.2_Missense_Mutation_p.E272K|POLK_uc003kef.2_Missense_Mutation_p.E182K	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	272	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AGTGAACTTTGAAGAACAAAA	0.408								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.076483	0	24	38										A	74877153	G	A	74877153	3	1	108	1	0	0	0	0	1	0	0	0	12204	1291	45	1	836	1	POLK	5	74877153	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	31754913	74877153	106038107	67	32945										
POLK	51426	broad.mit.edu	37	chr5	74892196	74892196	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ataagtttgtaaaacctctaGaaatgtctcataagaagagt	7	5	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74892196G>A	uc003kdw.2	+	13	1774	c.1678G>A	c.(1678-1680)GAA>AAA	p.E560K	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.E362K|POLK_uc003kec.2_Missense_Mutation_p.E470K|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.E470K	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	560					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AAAACCTCTAGAAATGTCTCA	0.358								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.083992	0	24	23										A	74892196	G	A	74892196	3	1	108	1	0	0	0	0	1	0	0	0	12204	943	33	1	1724	1	POLK	5	74892196	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	15043	74892196	106023064	68	32946										
POC5	134359	broad.mit.edu	37	chr5	74970365	74970365	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctactttcaggatgaatggtCcggggatattttgctgcagt	12	7	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:74970365C>A	uc003keh.3	-	12	1820	c.1623G>T	c.(1621-1623)CGG>CGT	p.R541R	POC5_uc010izu.2_Silent_p.R365R|POC5_uc003keg.3_Silent_p.R516R	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	541					cell cycle	centriole				lung(1)	1						GATGAATGGTCCGGGGATATT	0.398													1	0	8.92586e-32	0.139131	9.8667e-32	92	79										A	74970365	C	A	74970365	2	1	108	1	0	0	0	0	0	0	0	1	12177	842	30	3		3	POC5	5	74970365	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	78169	74970365	105944895	69	32947										
ACOT12	134526	broad.mit.edu	37	chr5	80640791	80640791	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taaatgagaaaagcactgttGatgtgacgccctcggccctc	10	11	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:80640791G>A	uc003khl.3	-	8	898	c.843C>T	c.(841-843)ATC>ATT	p.I281I	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	281	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		AAGCACTGTTGATGTGACGCC	0.493													0	0	0	0.104719	0	44	46										A	80640791	G	A	80640791	2	1	108	1	0	0	0	0	0	0	0	1	150	1280	45	1		1	ACOT12	5	80640791	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5670426	80640791	100274469	70	32948										
UBE2B	7320	broad.mit.edu	37	chr5	133724024	133724024	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttgtctttgcagtgtatgctGatggtagcatatgtttagat	11	4	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:133724024G>T	uc003kzh.2	+	5	667	c.250G>T	c.(250-252)GAT>TAT	p.D84Y		NM_003337	NP_003328	P63146	UBE2B_HUMAN	ubiquitin-conjugating enzyme E2B	84					canonical Wnt receptor signaling pathway|histone H2A ubiquitination|negative regulation of cAMP-mediated signaling|postreplication repair|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein stabilization|response to drug|response to UV	cytoplasm|plasma membrane|replication fork	ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGTGTATGCTGATGGTAGCAT	0.348								Direct_reversal_of_damage|Rad6_pathway					1	0	4.96729e-08	0.049695	5.18271e-08	20	44										T	133724024	G	T	133724024	3	4	108	1	0	0	0	0	1	0	0	0	16842	1290	45	3	268	3	UBE2B	5	133724024	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	53083233	133724024	47191236	71	32949										
PCDHAC2	56134	broad.mit.edu	37	chr5	140348520	140348520	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tttatatttcttttgacaatCatcattttgagcatcatcaa	3	7	5	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:140348520C>T	uc003lii.2	+	1	2409	c.2169C>T	c.(2167-2169)ATC>ATT	p.I723I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.I723I	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	723	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGACAATCATCATTTTGA	0.433													0	0	0	0.11911	0	14	85										T	140348520	C	T	140348520	2	4	108	1	0	0	0	0	0	0	0	1	11533	816	29	1		1	PCDHAC2	5	140348520	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6624496	140348520	40566740	72	32950										
PCDHAC2	56134	broad.mit.edu	37	chr5	140348753	140348753	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggcctgtctgacagcaggctCagggagtgacactttcatgt	13	10	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:140348753C>T	uc003lii.2	+	1	2642	c.2402C>T	c.(2401-2403)TCA>TTA	p.S801L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.S801L	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	801	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGGCTCAGGGAGTGAC	0.552													0	0	0	0.116897	0	28	54										T	140348753	C	T	140348753	3	4	108	1	0	0	0	0	1	0	0	0	11533	838	29	1	2404	1	PCDHAC2	5	140348753	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	233	140348753	40566507	73	32951										
RBM22	55696	broad.mit.edu	37	chr5	150080509	150080509	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctcaccgcatcctcccagttCtgcctgttgtaggtgttgga	10	13	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:150080509C>G	uc003lst.2	-	1	161	c.39G>C	c.(37-39)CAG>CAC	p.Q13H		NM_018047	NP_060517	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	13					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding				0		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTCCCAGTTCTGCCTGTTGT	0.637											OREG0016939	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.064281	0	33	31										G	150080509	C	G	150080509	3	3	108	1	0	0	0	0	1	0	0	0	13122	912	32	1	1267	1	RBM22	5	150080509	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	9731756	150080509	30834751	74	32952										
ANXA6	309	broad.mit.edu	37	chr5	150515861	150515861	+	Frame_Shift_Del	DEL	C	C	-													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctggaagtggccagaggtgtCgccgatgatgtcagcctcca							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:150515861delC	uc003ltl.1	-	7	597	c.445delG	c.(445-447)GACfs	p.D149fs	ANXA6_uc011dcp.1_Frame_Shift_Del_p.D117fs|ANXA6_uc003ltm.1_Frame_Shift_Del_p.D149fs|ANXA6_uc003ltn.1_Intron|ANXA6_uc003lto.1_Intron	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	149	Annexin 2.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCAGAGGTGTCGCCGATGATG	0.547																		27	34	---	---								-	150515861	C	-	150515861	7	5	108	1	0	1	0	1	0	0	0	0	722	884	31	0	1656	0	ANXA6	5	150515861	Frame_Shift_Del	DEL	C	TCGA-GC-A3YS-01A-11D-A23M-08	435352	150515861	30399399	75	32953										
MSX2	4488	broad.mit.edu	37	chr5	174156555	174156555	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgtgggactctatgccacgcCagtgggatatggcatgtacc	13	10	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr5:174156555C>T	uc003mcy.2	+	2	861	c.773C>T	c.(772-774)CCA>CTA	p.P258L		NM_002449	NP_002440	P35548	MSX2_HUMAN	msh homeobox 2	258					cranial suture morphogenesis|negative regulation of transcription, DNA-dependent|osteoblast differentiation	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0196)|all_lung(126;0.0303)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TATGCCACGCCAGTGGGATAT	0.547													0	0	0	0.108266	0	27	58										T	174156555	C	T	174156555	3	4	108	1	0	0	0	0	1	0	0	0	9896	594	21	2	779	2	MSX2	5	174156555	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	23640694	174156555	6758705	76	32954										
SLC35B3	51000	broad.mit.edu	37	chr6	8417151	8417151	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agtgcaccaaaaattttaatCaaagccagaacaaaggagat	7	7	1	2	rs145512512		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:8417151C>G	uc010joe.2	-	9	1117	c.951G>C	c.(949-951)TTG>TTC	p.L317F	SLC35B3_uc003mya.2_Missense_Mutation_p.L285F|SLC35B3_uc003myc.2_RNA|SLC35B3_uc003myb.2_Missense_Mutation_p.L317F|SLC35B3_uc011did.1_Missense_Mutation_p.L317F|SLC35B3_uc003myd.2_RNA	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	317	Helical; (Potential).				transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)					AAATTTTAATCAAAGCCAGAA	0.348													0	0	0	0.139131	0	45	65										G	8417151	C	G	8417151	3	3	108	1	0	0	0	0	1	0	0	0	14577	825	29	1	266	1	SLC35B3	6	8417151	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		8417151	162697916	77	32955										
JARID2	3720	broad.mit.edu	37	chr6	15452374	15452374	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctctaaaaggaagcctaagaCagaagattttcttacctttc	6	9	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:15452374C>T	uc003nbj.2	+	4	705	c.461C>T	c.(460-462)ACA>ATA	p.T154I	JARID2_uc011diu.1_Intron|JARID2_uc011div.1_5'UTR|JARID2_uc011diw.1_Missense_Mutation_p.T116I	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	154					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AAGCCTAAGACAGAAGATTTT	0.488													0	0	0	0.144211	0	31	74										T	15452374	C	T	15452374	3	4	108	1	0	0	0	0	1	0	0	0	7945	478	17	2	475	2	JARID2	6	15452374	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	7035223	15452374	155662693	78	32956										
SLC17A2	10246	broad.mit.edu	37	chr6	25918715	25918715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tttaagagaaagtgactcacCaaagatgtagaagataaaag	9	4	1	5			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:25918715C>T	uc011dkb.1	-	5	732	c.649G>A	c.(649-651)GGT>AGT	p.G217S	SLC17A2_uc011dkc.1_Missense_Mutation_p.G217S|SLC17A2_uc003nfl.2_Missense_Mutation_p.G217S			O00624	NPT3_HUMAN	SubName: Full=Solute carrier family 17 (Sodium phosphate), member 2, isoform CRA_b; SubName: Full=Putative uncharacterized protein SLC17A2;	217	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			ovary(1)	1						AGTGACTCACCAAAGATGTAG	0.443													0	0	0	0.069234	0	11	59										T	25918715	C	T	25918715	3	4	108	1	0	0	0	0	1	0	0	0	14417	608	21	2	685	2	SLC17A2	6	25918715	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	10466341	25918715	145196352	79	32957										
FLOT1	10211	broad.mit.edu	37	chr6	30698322	30698322	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctcgggcccctatggcaaaGgcctcagcttccccacgcat	10	17	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30698322G>C	uc003nrm.2	-	11	1136	c.972C>G	c.(970-972)GCC>GCG	p.A324A	FLOT1_uc011dmr.1_Silent_p.A276A	NM_005803	NP_005794	O75955	FLOT1_HUMAN	flotillin 1	324						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction					0						CTATGGCAAAGGCCTCAGCTT	0.567													0	0	0	0.0918	0	25	249										C	30698322	G	C	30698322	2	2	108	1	0	0	0	0	0	0	0	1	5936	987	35	4		4	FLOT1	6	30698322	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4779607	30698322	140416745	80	32958										
VARS2	57176	broad.mit.edu	37	chr6	30884992	30884992	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctttaagatcagccatctcGgacattgaggtgaggcggag	14	8	2	3	rs59234326	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30884992G>A	uc003nsc.1	+	8	1496	c.864G>A	c.(862-864)TCG>TCA	p.S288S	VARS2_uc003nsd.2_Silent_p.S288S|VARS2_uc011dmx.1_Silent_p.S288S|VARS2_uc011dmy.1_Silent_p.S148S|VARS2_uc011dmz.1_Silent_p.S318S|VARS2_uc011dna.1_Silent_p.S288S|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'Flank|VARS2_uc010jsg.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	288					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CAGCCATCTCGGACATTGAGG	0.438													0	0	0	0.139131	0	105	119										A	30884992	G	A	30884992	2	1	108	1	0	0	0	0	0	0	0	1	17121	1103	39	2		2	VARS2	6	30884992	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	186670	30884992	140230075	81	32959										
VARS2	57176	broad.mit.edu	37	chr6	30889068	30889068	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttccagcctacctggttgtaGaggaccatgcgcaggtgggt	14	10	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:30889068G>C	uc003nsc.1	+	16	2250	c.1618G>C	c.(1618-1620)GAG>CAG	p.E540Q	VARS2_uc011dmx.1_Missense_Mutation_p.E540Q|VARS2_uc011dmy.1_Missense_Mutation_p.E400Q|VARS2_uc011dmz.1_Missense_Mutation_p.E570Q|VARS2_uc011dna.1_Missense_Mutation_p.E538Q|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'UTR|VARS2_uc010jsg.1_5'UTR|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	540					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CCTGGTTGTAGAGGACCATGC	0.612													0	0	0	0.0918	0	25	61										C	30889068	G	C	30889068	3	2	108	1	0	0	0	0	1	0	0	0	17121	943	33	1	1774	1	VARS2	6	30889068	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4076	30889068	140225999	82	32960										
ATP6V1G2	534	broad.mit.edu	37	chr6	31513918	31513918	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctctggaattcgtgctctcGctctctgcggtattgctcca	10	13	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:31513918G>A	uc003nua.2	-	2	442	c.151C>T	c.(151-153)CGA>TGA	p.R51*	BAT1_uc003ntv.2_5'UTR|ATP6V1G2_uc003ntz.2_Nonsense_Mutation_p.R10*|NFKBIL1_uc011dnr.1_5'Flank|NFKBIL1_uc011dns.1_5'Flank|NFKBIL1_uc011dnt.1_5'Flank|NFKBIL1_uc003nuc.2_5'Flank|NFKBIL1_uc003nub.2_5'Flank	NM_130463	NP_569730	O95670	VATG2_HUMAN	ATPase, H+ transporting, lysosomal, V1 subunit	51					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|melanosome|vacuolar proton-transporting V-type ATPase complex	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|protein binding				0						TCGTGCTCTCGCTCTCTGCGG	0.582													0	0	0	0.139131	0	52	117										A	31513918	G	A	31513918	4	1	108	1	0	0	0	0	0	1	0	0	1187	1095	38	2	213	2	ATP6V1G2	6	31513918	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	624850	31513918	139601149	83	32961										
BAT2	7916	broad.mit.edu	37	chr6	31601375	31601375	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctcagggcccctctcctagGcccccaacccgatacgagcc	8	21	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:31601375G>A	uc003nvb.3	+	17	4788	c.4539G>A	c.(4537-4539)AGG>AGA	p.R1513R	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Silent_p.R1513R	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1513	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CCTCTCCTAGGCCCCCAACCC	0.612													0	0	0	0.09319	0	12	40										A	31601375	G	A	31601375	2	1	108	1	0	0	0	0	0	0	0	1	1319	1194	42	2		2	BAT2	6	31601375	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	87457	31601375	139513692	84	32962										
TULP1	7287	broad.mit.edu	37	chr6	35471368	35471368	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gatggggaccctctcgttctCcgcactcatgccaggaatga	11	13	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:35471368C>T	uc003okv.3	-	13	1303	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	TULP1_uc003okw.3_Missense_Mutation_p.E378K	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	431					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						CTCTCGTTCTCCGCACTCATG	0.637													0	0	0	0.115264	0	2	5										T	35471368	C	T	35471368	3	4	108	1	0	0	0	0	1	0	0	0	16770	864	30	1	349	1	TULP1	6	35471368	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3869993	35471368	135643699	85	32963										
CYP39A1	51302	broad.mit.edu	37	chr6	46620303	46620303	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccaggattataatcactgttGgggaaattagttccatgttt	9	6	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:46620303G>T	uc003oyf.1	-	1	221	c.17C>A	c.(16-18)CCA>CAA	p.P6Q	CYP39A1_uc011dwa.1_Missense_Mutation_p.P6Q|CYP39A1_uc010jzd.1_5'UTR|SLC25A27_uc011dwb.1_5'Flank|SLC25A27_uc003oyg.2_5'Flank|SLC25A27_uc003oyh.2_5'Flank|SLC25A27_uc011dwc.1_5'Flank	NM_016593	NP_057677	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A,	6					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1						AATCACTGTTGGGGAAATTAG	0.483													1	0	5.42381e-49	0.139131	6.07763e-49	88	264										T	46620303	G	T	46620303	3	4	108	1	0	0	0	0	1	0	0	0	4177	1348	47	4	1440	4	CYP39A1	6	46620303	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	11148935	46620303	124494764	86	32964										
RNGTT	8732	broad.mit.edu	37	chr6	89388140	89388140	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aacattctgaggaagtaaccTacaaagaaaaaaaagcatta	6	6	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:89388140T>C	uc003pmr.2	-	14	1660	c.1440_splice	c.e14-1	p.G480_splice	RNGTT_uc003pms.2_Splice_Site_p.G457_splice|RNGTT_uc011dzu.1_Splice_Site_p.G397_splice|RNGTT_uc003pmt.2_Intron	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		GGAAGTAACCTACAAAGAAAA	0.254													0	0	0	0.076483	0	22	31										C	89388140	T	C	89388140	5	2	108	1	0	0	0	0	0	0	1	0	13503	1536	53	5	367	5	RNGTT	6	89388140	Splice_Site	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	42767837	89388140	81726927	87	32965										
ASCC3	10973	broad.mit.edu	37	chr6	101214503	101214503	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agtcaattctttcacaatgaTgcctagtggctctagacgtc	8	10	4	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:101214503T>C	uc003pqk.2	-	10	2004	c.1675A>G	c.(1675-1677)ATC>GTC	p.I559V	ASCC3_uc011eai.1_Missense_Mutation_p.I461V|ASCC3_uc003pql.2_Missense_Mutation_p.I559V	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	559	Helicase ATP-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTCACAATGATGCCTAGTGGC	0.383													0	0	0	0.09836	0	42	74										C	101214503	T	C	101214503	3	2	108	1	0	0	0	0	1	0	0	0	1033	1464	51	5	5065	5	ASCC3	6	101214503	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	11826363	101214503	69900564	88	32966										
GRIK2	2898	broad.mit.edu	37	chr6	102483434	102483434	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aaaggttatggcgttggcacTcccatgggtaggttatatgt	13	6	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:102483434T>C	uc003pqp.3	+	14	2553	c.2304T>C	c.(2302-2304)ACT>ACC	p.T768T	GRIK2_uc003pqo.3_Silent_p.T768T|GRIK2_uc010kcw.2_Silent_p.T768T	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	768	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GCGTTGGCACTCCCATGGGTA	0.443													0	0	0	0.131918	0	47	134										C	102483434	T	C	102483434	2	2	108	1	0	0	0	0	0	0	0	1	6774	1538	54	5		5	GRIK2	6	102483434	Silent	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	1268931	102483434	68631633	89	32967										
PPIL4	85313	broad.mit.edu	37	chr6	149867087	149867087	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctcaccacgcggccgttcttCggtgtacaagtcgatgacga	11	13	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:149867087C>T	uc003qmo.1	-	1	85	c.55G>A	c.(55-57)GAA>AAA	p.E19K	PPIL4_uc010kic.2_RNA|PPIL4_uc003qmp.1_Missense_Mutation_p.E19K	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	19	PPIase cyclophilin-type.				protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		GGCCGTTCTTCGGTGTACAAG	0.647													0	0	0	0.014758	0	5	9										T	149867087	C	T	149867087	3	4	108	1	0	0	0	0	1	0	0	0	12329	893	31	1	1475	1	PPIL4	6	149867087	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	47383653	149867087	21247980	90	32968										
SYNE1	23345	broad.mit.edu	37	chr6	152686043	152686043	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atccttcacactctgcagctGctgctgaatagtgggaatgc	10	11	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr6:152686043G>A	uc010kiw.2	-	63	10686	c.10084C>T	c.(10084-10086)CAG>TAG	p.Q3362*	SYNE1_uc003qot.3_Nonsense_Mutation_p.Q3369*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q3362*|SYNE1_uc010kja.1_Nonsense_Mutation_p.Q67*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3362	Spectrin 7.|HAT 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTGCAGCTGCTGCTGAATA	0.458										HNSCC(10;0.0054)			0	0	0	0.064281	0	37	93										A	152686043	G	A	152686043	4	1	108	1	0	0	0	0	0	1	0	0	15442	1328	46	2	16718	2	SYNE1	6	152686043	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	2818956	152686043	18429024	91	32969										
MAD1L1	8379	broad.mit.edu	37	chr7	2188842	2188842	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aagctccctctgctgcagctCaaccacgaatctggaaaggt	9	13	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:2188842C>G	uc003slh.1	-	11	1284	c.1018G>C	c.(1018-1020)GAG>CAG	p.E340Q	MAD1L1_uc003sle.1_Missense_Mutation_p.E69Q|MAD1L1_uc003slf.1_Missense_Mutation_p.E340Q|MAD1L1_uc003slg.1_Missense_Mutation_p.E340Q|MAD1L1_uc010ksh.1_Missense_Mutation_p.E340Q|MAD1L1_uc003sli.1_Missense_Mutation_p.E248Q|MAD1L1_uc010ksi.1_Missense_Mutation_p.E293Q|MAD1L1_uc010ksj.2_Missense_Mutation_p.E340Q	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	340	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		TGCTGCAGCTCAACCACGAAT	0.547													0	0	0	0.09319	0	12	34										G	2188842	C	G	2188842	3	3	108	1	0	0	0	0	1	0	0	0	9147	835	29	1	1174	1	MAD1L1	7	2188842	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		2188842	156949821	92	32970										
ANLN	54443	broad.mit.edu	37	chr7	36438775	36438775	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taacttggaaaataaacaacCagttgagtcgacatctgcaa	7	8	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:36438775C>T	uc003tff.2	+	3	464	c.260C>T	c.(259-261)CCA>CTA	p.P87L	ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Missense_Mutation_p.P87L|ANLN_uc010kxe.2_Missense_Mutation_p.P87L	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	87	Nuclear localization.|Interaction with CD2AP.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						AATAAACAACCAGTTGAGTCG	0.418													0	0	0	0.105934	0	14	51										T	36438775	C	T	36438775	3	4	108	1	0	0	0	0	1	0	0	0	694	594	21	2	270	2	ANLN	7	36438775	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	34249933	36438775	122699888	93	32971										
POLD2	5425	broad.mit.edu	37	chr7	44156568	44156568	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgggtgcccagcaggctctCgcctccaccgccacccaggc	11	20	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:44156568C>T	uc010kxz.2	-	7	1278	c.628G>A	c.(628-630)GAG>AAG	p.E210K	POLD2_uc003tke.3_Missense_Mutation_p.E210K|POLD2_uc010kya.2_Missense_Mutation_p.E210K|POLD2_uc003tkf.3_Missense_Mutation_p.E210K	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	210					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						AGCAGGCTCTCGCCTCCACCG	0.692													0	0	0	0.09319	0	12	20										T	44156568	C	T	44156568	3	4	108	1	0	0	0	0	1	0	0	0	12191	893	31	1	805	1	POLD2	7	44156568	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	7717793	44156568	114982095	94	32972										
TYW1	55253	broad.mit.edu	37	chr7	66463173	66463173	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atttgtgtccagattgtcatCaagacgcaggtaagtggagt	12	6	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:66463173C>G	uc003tvn.2	+	2	275	c.126C>G	c.(124-126)ATC>ATG	p.I42M	SBDS_uc003tvm.1_5'Flank|TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	42					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				AGATTGTCATCAAGACGCAGG	0.318													0	0	0	0.092188	0	39	118										G	66463173	C	G	66463173	3	3	108	1	0	0	0	0	1	0	0	0	16815	816	29	1	132	1	TYW1	7	66463173	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	22306605	66463173	92675490	95	32973										
BAZ1B	9031	broad.mit.edu	37	chr7	72892759	72892759	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agtggcgagccactcaatgaCttcttcaagtgtacgtgaca	10	10	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:72892759C>T	uc003tyc.2	-	7	1377	c.1032G>A	c.(1030-1032)AAG>AAA	p.K344K		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	344	Mediates the tyrosine-protein kinase activity.|Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				CACTCAATGACTTCTTCAAGT	0.423													0	0	0	0.059317	0	30	78										T	72892759	C	T	72892759	2	4	108	1	0	0	0	0	0	0	0	1	1330	564	20	2		2	BAZ1B	7	72892759	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6429586	72892759	86245904	96	32974										
SEMA3C	10512	broad.mit.edu	37	chr7	80418743	80418743	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggccttttgtggattgggtaGatggaattgtacatgagagg	16	3	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:80418743G>C	uc003uhj.2	-	12	1795	c.1233C>G	c.(1231-1233)ATC>ATG	p.I411M	SEMA3C_uc011kgw.1_Missense_Mutation_p.I429M	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	411	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						GGATTGGGTAGATGGAATTGT	0.453													0	0	0	0.139131	0	47	56										C	80418743	G	C	80418743	3	2	108	1	0	0	0	0	1	0	0	0	14026	932	33	1	1050	1	SEMA3C	7	80418743	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	7525984	80418743	78719920	97	32975										
BAIAP2L1	55971	broad.mit.edu	37	chr7	97944889	97944889	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccatctgcaatgaatttctgGatttcactctgacgagaagt	8	9	4	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:97944889G>T	uc003upj.2	-	7	785	c.522C>A	c.(520-522)ATC>ATA	p.I174I		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	174	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TGAATTTCTGGATTTCACTCT	0.383													1	0	2.20262e-25	0.054565	2.40875e-25	35	119										T	97944889	G	T	97944889	2	4	108	1	0	0	0	0	0	0	0	1	1302	1164	41	3		3	BAIAP2L1	7	97944889	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	17526146	97944889	61193774	98	32976										
SMURF1	57154	broad.mit.edu	37	chr7	98645380	98645380	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctgaagcgacagttcgtgtCtgaggactttcagcttctgg	13	9	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:98645380C>A	uc003upu.1	-	11	1477	c.1157G>T	c.(1156-1158)AGA>ATA	p.R386I	SMURF1_uc003upv.1_Missense_Mutation_p.R360I|SMURF1_uc003upt.2_Missense_Mutation_p.R360I	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	386					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			CAGTTCGTGTCTGAGGACTTT	0.562													1	0	1.77791e-30	0.139131	1.96002e-30	70	264										A	98645380	C	A	98645380	3	1	108	1	0	0	0	0	1	0	0	0	14819	913	32	3	1152	3	SMURF1	7	98645380	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	700491	98645380	60493283	99	32977										
SMURF1	57154	broad.mit.edu	37	chr7	98645441	98645441	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgggcaggaagctcctcgtCctccagagagccctcactgg	12	15	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:98645441C>A	uc003upu.1	-	11	1416	c.1096G>T	c.(1096-1098)GAC>TAC	p.D366Y	SMURF1_uc003upv.1_Missense_Mutation_p.D340Y|SMURF1_uc003upt.2_Missense_Mutation_p.D340Y	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	366					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			AGCTCCTCGTCCTCCAGAGAG	0.562													1	0	1.52378e-38	0.139131	1.69355e-38	69	290										A	98645441	C	A	98645441	3	1	108	1	0	0	0	0	1	0	0	0	14819	855	30	3	1213	3	SMURF1	7	98645441	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	61	98645441	60493222	100	32978										
ZKSCAN1	7586	broad.mit.edu	37	chr7	99621898	99621898	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccagtcccacttcaaacattCgtctcggaaaccccgcctct	5	18	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:99621898C>T	uc003usk.1	+	3	767	c.548C>T	c.(547-549)TCG>TTG	p.S183L	ZKSCAN1_uc003usj.2_Missense_Mutation_p.S182L|ZKSCAN1_uc003usl.1_Missense_Mutation_p.S147L|ZKSCAN1_uc003usm.1_Intron	NM_003439	NP_003430	P17029	ZKSC1_HUMAN	zinc finger protein 36	183					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTCAAACATTCGTCTCGGAAA	0.532													0	0	0	0.038395	0	17	57										T	99621898	C	T	99621898	3	4	108	1	0	0	0	0	1	0	0	0	17683	893	31	1	554	1	ZKSCAN1	7	99621898	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	976457	99621898	59516765	101	32979										
ACHE	43	broad.mit.edu	37	chr7	100491073	100491073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccagggtccattgggggcacCgctctgcagcacggccctgt	14	15	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:100491073C>T	uc003uxd.2	-	1	937	c.781G>A	c.(781-783)GGT>AGT	p.G261S	ACHE_uc003uxe.2_Missense_Mutation_p.G261S|ACHE_uc003uxf.2_Missense_Mutation_p.G261S|ACHE_uc003uxg.2_Missense_Mutation_p.G261S|ACHE_uc003uxh.2_Missense_Mutation_p.G261S|ACHE_uc003uxi.2_Missense_Mutation_p.G261S|ACHE_uc003uxj.1_Missense_Mutation_p.G380S	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	261					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	TTGGGGGCACCGCTCTGCAGC	0.726													0	0	0	0.105934	0	14	51										T	100491073	C	T	100491073	3	4	108	1	0	0	0	0	1	0	0	0	141	652	23	2	1214	2	ACHE	7	100491073	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	869175	100491073	58647590	102	32980										
GPR22	2845	broad.mit.edu	37	chr7	107114751	107114751	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtcagtaacattattacaatGaatcttcatgtacttgatgt	6	6	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:107114751G>T	uc003vef.2	+	3	1592	c.246G>T	c.(244-246)ATG>ATT	p.M82I	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	82	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						TTATTACAATGAATCTTCATG	0.363													1	0	5.22555e-25	0.139131	5.69934e-25	58	94										T	107114751	G	T	107114751	3	4	108	1	0	0	0	0	1	0	0	0	6682	1290	45	3	248	3	GPR22	7	107114751	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	6623678	107114751	52023912	103	32981										
ST7	7982	broad.mit.edu	37	chr7	116869839	116869839	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctcagcactttgtttgccccCttaaactttgtcatggagaa	7	11	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:116869839C>G	uc011knn.1	+	14	1371	c.1366C>G	c.(1366-1368)CTT>GTT	p.L456V	ST7_uc003vio.2_Silent_p.P531P|ST7_uc003viq.2_Silent_p.P508P|ST7_uc011knm.1_Silent_p.P511P|ST7_uc003vir.2_Silent_p.P474P	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TGTTTGCCCCCTTAAACTTTG	0.498													0	0	0	0.139131	0	89	448										G	116869839	C	G	116869839	3	3	108	1	0	0	0	0	1	0	0	0	15228	668	24	4	1848	4	ST7	7	116869839	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	9755088	116869839	42268824	104	32982										
IMPDH1	3614	broad.mit.edu	37	chr7	128038653	128038653	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cagctcatcgcaatcattgaCgataggcagcttccctgaca	8	13	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:128038653C>T	uc011kol.1	-	7	740	c.634G>A	c.(634-636)GTC>ATC	p.V212I	IMPDH1_uc011kom.1_Missense_Mutation_p.V207I|IMPDH1_uc003vmt.2_Missense_Mutation_p.V187I|IMPDH1_uc003vmu.2_Missense_Mutation_p.V297I|IMPDH1_uc003vmw.2_Missense_Mutation_p.V287I|IMPDH1_uc011kon.1_Missense_Mutation_p.V264I|IMPDH1_uc003vmv.2_Missense_Mutation_p.V261I|IMPDH1_uc003vmx.2_Missense_Mutation_p.V220I|IMPDH1_uc003vmy.2_Missense_Mutation_p.V228I	NM_001142573	NP_001136045	P20839	IMDH1_HUMAN	inosine monophosphate dehydrogenase 1 isoform e	212	CBS 2.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			skin(2)|lung(1)|central_nervous_system(1)	4					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CAATCATTGACGATAGGCAGC	0.542											OREG0018292	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.069234	0	11	158										T	128038653	C	T	128038653	3	4	108	1	0	0	0	0	1	0	0	0	7726	536	19	2	942	2	IMPDH1	7	128038653	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	11168814	128038653	31100010	105	32983										
TMEM139	135932	broad.mit.edu	37	chr7	142983872	142983872	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctatgatgtctgctttggtCaccctgatgatgatagtgtt	10	8	2	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:142983872C>T	uc010lov.2	+	4	740	c.601C>T	c.(601-603)CAC>TAC	p.H201Y	CASP2_uc003wco.2_5'Flank|CASP2_uc003wcp.2_5'Flank|CASP2_uc011kta.1_5'Flank|CASP2_uc003wcq.2_5'Flank|TMEM139_uc003wck.3_Missense_Mutation_p.H201Y|TMEM139_uc003wcl.2_Missense_Mutation_p.H201Y|TMEM139_uc003wcm.2_Missense_Mutation_p.H201Y|TMEM139_uc003wcn.2_RNA	NM_153345	NP_699176	Q8IV31	TM139_HUMAN	transmembrane protein 139 precursor	201	Cytoplasmic (Potential).					integral to membrane					0	Melanoma(164;0.059)					CTGCTTTGGTCACCCTGATGA	0.502													0	0	0	0.139131	0	70	67										T	142983872	C	T	142983872	3	4	108	1	0	0	0	0	1	0	0	0	16051	826	29	1	607	1	TMEM139	7	142983872	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	14945219	142983872	16154791	106	32984										
FAM115A	9747	broad.mit.edu	37	chr7	143573631	143573631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaagcagttcacatggaacaGcatcttcgggtacatcccag	10	11	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr7:143573631G>A	uc003wdo.1	-	2	204	c.71C>T	c.(70-72)GCT>GTT	p.A24V	FAM115A_uc011ktu.1_Intron|FAM115A_uc003wdp.1_Missense_Mutation_p.A24V	NM_014719	NP_055534	Q9Y4C2	F115A_HUMAN	hypothetical protein LOC9747	24											0	Melanoma(164;0.0903)					ACATGGAACAGCATCTTCGGG	0.527													0	0	0	0.009096	0	4	60										A	143573631	G	A	143573631	3	1	108	1	0	0	0	0	1	0	0	0	5405	971	34	2	2726	2	FAM115A	7	143573631	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	589759	143573631	15565032	107	32985										
BLK	640	broad.mit.edu	37	chr8	11405588	11405588	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	actacaccgctatgaatgatCgggacctgcagatgctgaag	11	10	0	4	rs149393791	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:11405588C>A	uc003wty.2	+	4	804	c.223C>A	c.(223-225)CGG>AGG	p.R75R	BLK_uc003wtz.2_Silent_p.R4R	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	75	SH3.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TATGAATGATCGGGACCTGCA	0.567													1	0	5.26018e-13	0.062417	5.63197e-13	21	33										A	11405588	C	A	11405588	2	1	108	1	0	0	0	0	0	0	0	1	1444	875	31	3		3	BLK	8	11405588	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		11405588	134958434	108	32986										
WRN	7486	broad.mit.edu	37	chr8	30933803	30933803	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taaattggaaaacccacggaGgttaaatattaccttttttt	6	6	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:30933803G>A	uc003xio.3	+	8	1627	c.839G>A	c.(838-840)AGG>AAG	p.R280K		NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	280					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AACCCACGGAGGTTAAATATT	0.328			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	0.099896	0	28	30										A	30933803	G	A	30933803	3	1	108	1	0	0	0	0	1	0	0	0	17399	1014	35	2	865	2	WRN	8	30933803	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	19528215	30933803	115430219	109	32987										
KCNU1	157855	broad.mit.edu	37	chr8	36644853	36644853	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acatcaggtaccatcgctagGagccatgtaagaagcctcca	9	12	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:36644853G>A	uc010lvw.2	+	2	312	c.225G>A	c.(223-225)AGG>AGA	p.R75R	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	75	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CCATCGCTAGGAGCCATGTAA	0.428													0	0	0	0.038147	0	8	17										A	36644853	G	A	36644853	2	1	108	1	0	0	0	0	0	0	0	1	8093	1165	41	1		1	KCNU1	8	36644853	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5711050	36644853	109719169	110	32988										
TACC1	6867	broad.mit.edu	37	chr8	38677879	38677879	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agcctacagacccagtggcaCgagacgggcctctctcccaa	10	16	1	2	rs149014810	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:38677879C>T	uc010lwp.2	+	3	1496	c.1117C>T	c.(1117-1119)CGA>TGA	p.R373*	TACC1_uc011lby.1_Nonsense_Mutation_p.R178*|TACC1_uc003xma.2_Intron|TACC1_uc003xlz.2_Nonsense_Mutation_p.R178*|TACC1_uc003xmc.3_Nonsense_Mutation_p.R178*|TACC1_uc011lbz.1_Nonsense_Mutation_p.R389*|TACC1_uc003xmb.3_Nonsense_Mutation_p.R328*|TACC1_uc003xme.1_Intron|TACC1_uc003xmd.1_Intron|TACC1_uc010lwo.1_Intron|TACC1_uc003xmf.3_Intron|TACC1_uc011lca.1_Nonsense_Mutation_p.R373*|TACC1_uc011lcb.1_Nonsense_Mutation_p.R178*|TACC1_uc011lcc.1_Nonsense_Mutation_p.R178*|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Nonsense_Mutation_p.R178*|TACC1_uc010lwq.2_Nonsense_Mutation_p.R178*	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	373	Interaction with YEATS4.|SPAZ 2.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			CCCAGTGGCACGAGACGGGCC	0.527													0	0	0	0.050027	0	32	205										T	38677879	C	T	38677879	4	4	108	1	0	0	0	0	0	1	0	0	15498	528	19	2	1127	2	TACC1	8	38677879	Nonsense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2033026	38677879	107686143	111	32989										
PRKDC	5591	broad.mit.edu	37	chr8	48740729	48740729	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaagtgtgtgcagactttacCtgaatacaagagacaaaggg	12	6	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:48740729C>T	uc003xqi.2	-	63	8634	c.8577G>A	c.(8575-8577)CAG>CAA	p.Q2859Q	PRKDC_uc003xqj.2_Silent_p.Q2859Q|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2859	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CAGACTTTACCTGAATACAAG	0.383								NHEJ					0	0	0	0.132662	0	16	11										T	48740729	C	T	48740729	2	4	108	1	0	0	0	0	0	0	0	1	12521	695	24	2		2	PRKDC	8	48740729	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	10062850	48740729	97623293	112	32990										
EFCAB1	79645	broad.mit.edu	37	chr8	49637345	49637345	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atctttgaatacttgagcttCaaattccatctggctctgta	6	9	4	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:49637345C>T	uc003xqo.2	-	6	752	c.592G>A	c.(592-594)GAA>AAA	p.E198K	EFCAB1_uc003xqn.3_Intron|EFCAB1_uc011ldj.1_Missense_Mutation_p.E146K|EFCAB1_uc010lxx.2_RNA|EFCAB1_uc011ldk.1_RNA	NM_024593	NP_078869	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1 isoform a	198							calcium ion binding				0		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				ACTTGAGCTTCAAATTCCATC	0.313													0	0	0	0.083992	0	24	14										T	49637345	C	T	49637345	3	4	108	1	0	0	0	0	1	0	0	0	4933	835	29	1	47	1	EFCAB1	8	49637345	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	896616	49637345	96726677	113	32991										
NSMAF	8439	broad.mit.edu	37	chr8	59506850	59506850	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccgtgattccagtaactgctCtgctcaaaaacaaagtttca	6	11	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:59506850C>G	uc003xtt.2	-	23	2107	c.1893_splice	c.e23-1	p.E631_splice	NSMAF_uc011lee.1_Splice_Site_p.E662_splice	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation						ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				AGTAACTGCTCTGCTCAAAAA	0.388													0	0	0	0.009096	0	4	43										G	59506850	C	G	59506850	5	3	108	1	0	0	0	0	0	0	1	0	10674	927	32	1	897	1	NSMAF	8	59506850	Splice_Site	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	9869505	59506850	86857172	114	32992										
C8orf34	116328	broad.mit.edu	37	chr8	69358639	69358639	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgcaaagaagcctaaaaaatCaaaaagtgaccttgctgtgt	8	7	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:69358639C>G	uc010lyz.2	+	3	342	c.293C>G	c.(292-294)TCA>TGA	p.S98*	C8orf34_uc010lyx.1_Nonsense_Mutation_p.S98*|C8orf34_uc010lyy.1_Nonsense_Mutation_p.S98*|C8orf34_uc003xyb.2_Nonsense_Mutation_p.S73*	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	98					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CCTAAAAAATCAAAAAGTGAC	0.328													0	0	0	0.02938	0	6	77										G	69358639	C	G	69358639	4	3	108	1	0	0	0	0	0	1	0	0	2422	838	29	1	224	1	C8orf34	8	69358639	Nonsense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	9851789	69358639	77005383	115	32993										
ZFHX4	79776	broad.mit.edu	37	chr8	77764196	77764196	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcaaactcctgatttaatctCtgctcaacctgcacatcacc	4	15	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:77764196C>G	uc003yav.2	+	10	5291	c.4904C>G	c.(4903-4905)TCT>TGT	p.S1635C	ZFHX4_uc003yau.1_Missense_Mutation_p.S1680C|ZFHX4_uc003yaw.1_Missense_Mutation_p.S1635C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1635						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GATTTAATCTCTGCTCAACCT	0.418										HNSCC(33;0.089)			0	0	0	0.139131	0	54	31										G	77764196	C	G	77764196	3	3	108	1	0	0	0	0	1	0	0	0	17632	913	32	1	5073	1	ZFHX4	8	77764196	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	8405557	77764196	68599826	116	32994										
FBXO43	286151	broad.mit.edu	37	chr8	101154324	101154324	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tggagttgacaattggaggaGagtccgccccatttcctgct	12	10	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:101154324G>A	uc003yjd.2	-	2	871	c.158C>T	c.(157-159)TCT>TTT	p.S53F	FBXO43_uc003yje.2_Missense_Mutation_p.S19F|FBXO43_uc010mbp.1_Missense_Mutation_p.S53F	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	53					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			AATTGGAGGAGAGTCCGCCCC	0.423													0	0	0	0.139131	0	95	39										A	101154324	G	A	101154324	3	1	108	1	0	0	0	0	1	0	0	0	5752	942	33	1	1984	1	FBXO43	8	101154324	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	23390128	101154324	45209698	117	32995										
TAF2	6873	broad.mit.edu	37	chr8	120770342	120770342	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggtacagggtcattctgaatCatattaagtagccattgcag	10	7	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:120770342C>T	uc003you.2	-	21	3009	c.2739G>A	c.(2737-2739)ATG>ATA	p.M913I		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	913					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CATTCTGAATCATATTAAGTA	0.284													0	0	0	0.043863	0	17	155										T	120770342	C	T	120770342	3	4	108	1	0	0	0	0	1	0	0	0	15521	826	29	1	884	1	TAF2	8	120770342	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	19616018	120770342	25593680	118	32996										
ATAD2	29028	broad.mit.edu	37	chr8	124371897	124371897	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tttataaatgccttttaattCatctttccgaaaatttagtg	4	6	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:124371897C>T	uc003yqh.3	-	10	1294	c.1186G>A	c.(1186-1188)GAA>AAA	p.E396K	ATAD2_uc011lii.1_Missense_Mutation_p.E187K|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E396K	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CCTTTTAATTCATCTTTCCGA	0.358													0	0	0	0.021553	0	6	67										T	124371897	C	T	124371897	3	4	108	1	0	0	0	0	1	0	0	0	1071	835	29	1	3062	1	ATAD2	8	124371897	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3601555	124371897	21992125	119	32997										
FAM135B	51059	broad.mit.edu	37	chr8	139380157	139380157	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aaagcatacttaccctctctGaaagagatccacattataaa	4	10	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:139380157G>C	uc003yuy.2	-	2	241	c.70C>G	c.(70-72)CAG>GAG	p.Q24E	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	24										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACCCTCTCTGAAAGAGATCC	0.328										HNSCC(54;0.14)			0	0	0	0.139131	0	57	34										C	139380157	G	C	139380157	3	2	108	1	0	0	0	0	1	0	0	0	5449	1299	45	1	4226	1	FAM135B	8	139380157	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	15008260	139380157	6983865	120	32998										
MAPK15	225689	broad.mit.edu	37	chr8	144803252	144803252	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gggtccagctctctgtgcctGagtaccgcagccgcgtctat	12	14	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr8:144803252G>C	uc003yzj.2	+	10	1041	c.1000G>C	c.(1000-1002)GAG>CAG	p.E334Q		NM_139021	NP_620590	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	334					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCTGTGCCTGAGTACCGCAG	0.652													0	0	0	0.014758	0	4	27										C	144803252	G	C	144803252	3	2	108	1	0	0	0	0	1	0	0	0	9277	1291	45	1	1038	1	MAPK15	8	144803252	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5423095	144803252	1560770	121	32999										
MPDZ	8777	broad.mit.edu	37	chr9	13119644	13119644	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgacacaaatactccagtatCgtttctacacacaattttga	4	10	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:13119644C>T	uc010mia.1	-	38	5293	c.5236G>A	c.(5236-5238)GAT>AAT	p.D1746N	MPDZ_uc003zkx.3_Missense_Mutation_p.D11N|MPDZ_uc003zky.3_Missense_Mutation_p.D280N|MPDZ_uc010mib.2_Missense_Mutation_p.D451N|MPDZ_uc010mhx.2_Missense_Mutation_p.D568N|MPDZ_uc011lmm.1_Missense_Mutation_p.D605N|MPDZ_uc003zkz.3_Missense_Mutation_p.D439N|MPDZ_uc010mhy.2_Missense_Mutation_p.D1746N|MPDZ_uc010mhz.2_Missense_Mutation_p.D1713N|MPDZ_uc011lmn.1_Missense_Mutation_p.D1713N|MPDZ_uc003zlb.3_Missense_Mutation_p.D1746N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1746	PDZ 11.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ACTCCAGTATCGTTTCTACAC	0.348													0	0	0	0.047766	0	9	58										T	13119644	C	T	13119644	3	4	108	1	0	0	0	0	1	0	0	0	9722	884	31	1	921	1	MPDZ	9	13119644	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		13119644	128093787	122	33000										
PIGO	84720	broad.mit.edu	37	chr9	35094274	35094274	+	Silent	SNP	G	G	T													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tctaggtctctgacattgaaGgatgggaagaagaaagcttt							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094274G>T	uc003zwd.2	-	3	990	c.594C>A	c.(592-594)TCC>TCA	p.S198S	PIGO_uc003zwc.1_Silent_p.S198S|PIGO_uc003zwe.2_Silent_p.S198S|PIGO_uc003zwf.2_Silent_p.S198S|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	198					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TGACATTGAAGGATGGGAAGA	0.502													1	0	6.44725e-10	0.069288	6.81376e-10	12	32										T	35094274	G	T	35094274	2	4	108	1	0	0	0	0	0	0	0	1	11894	987	35	4		4	PIGO	9	35094274	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	21974630	35094274	106119157	123	33001	164	2								
PIGO	84720	broad.mit.edu	37	chr9	35094283	35094283	+	Missense_Mutation	SNP	G	G	T													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgacattgaaggatgggaaGaagaaagctttggagaaagc							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094283G>T	uc003zwd.2	-	3	981	c.585C>A	c.(583-585)TTC>TTA	p.F195L	PIGO_uc003zwc.1_Missense_Mutation_p.F195L|PIGO_uc003zwe.2_Missense_Mutation_p.F195L|PIGO_uc003zwf.2_Missense_Mutation_p.F195L|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	195					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGATGGGAAGAAGAAAGCTT	0.498													1	0	4.35082e-09	0.055883	4.56278e-09	10	30										T	35094283	G	T	35094283	3	4	108	1	0	0	0	0	1	0	0	0	11894	933	33	3	2720	3	PIGO	9	35094283	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	9	35094283	106119148	124	33002	164	2								
PIGO	84720	broad.mit.edu	37	chr9	35094310	35094310	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctttggagaaagcaccaggGaaaaggtctttccaggtatc	12	8	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35094310G>A	uc003zwd.2	-	3	954	c.558C>T	c.(556-558)TTC>TTT	p.F186F	PIGO_uc003zwc.1_Silent_p.F186F|PIGO_uc003zwe.2_Silent_p.F186F|PIGO_uc003zwf.2_Silent_p.F186F|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	186					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AAGCACCAGGGAAAAGGTCTT	0.502													0	0	0	0.144211	0	20	31										A	35094310	G	A	35094310	2	1	108	1	0	0	0	0	0	0	0	1	11894	1165	41	1		1	PIGO	9	35094310	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	27	35094310	106119121	125	33003										
CREB3	10488	broad.mit.edu	37	chr9	35735135	35735135	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caaattctgaaacgtgtgcgGaggaagattcgaaataaaag	11	5	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:35735135G>C	uc003zxv.2	+	5	918	c.465G>C	c.(463-465)CGG>CGC	p.R155R	TLN1_uc003zxt.2_5'Flank|TLN1_uc003zxu.3_5'Flank|CREB3_uc010mla.2_Silent_p.R74R	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	179	Cytoplasmic (Potential).|Basic motif.				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		AACGTGTGCGGAGGAAGATTC	0.348													0	0	0	0.134883	0	30	28										C	35735135	G	C	35735135	2	2	108	1	0	0	0	0	0	0	0	1	3855	1161	41	1		1	CREB3	9	35735135	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	640825	35735135	105478296	126	33004										
RASEF	158158	broad.mit.edu	37	chr9	85613323	85613323	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gagctgcagaactgttcgttCtccatccacaatgagggttt	10	10	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:85613323C>G	uc004amo.1	-	13	2023	c.1762G>C	c.(1762-1764)GAA>CAA	p.E588Q		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	588					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						ACTGTTCGTTCTCCATCCACA	0.453													0	0	0	0.139131	0	179	84										G	85613323	C	G	85613323	3	3	108	1	0	0	0	0	1	0	0	0	13068	922	32	1	480	1	RASEF	9	85613323	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	49878188	85613323	55600108	127	33005										
FOXE1	2304	broad.mit.edu	37	chr9	100617151	100617151	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcggcagcagtggcggcgtgGagaccacggtggacttctac	17	11	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:100617151G>C	uc004axu.2	+	1	1615	c.955G>C	c.(955-957)GAG>CAG	p.E319Q		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	319					cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				TGGCGGCGTGGAGACCACGGT	0.751													0	0	0	0.069234	0	8	3										C	100617151	G	C	100617151	3	2	108	1	0	0	0	0	1	0	0	0	6003	1175	41	1	957	1	FOXE1	9	100617151	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	15003828	100617151	40596280	128	33006										
C9orf156	51531	broad.mit.edu	37	chr9	100667150	100667150	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctatgtctacagtaaagtaGaaaaggcggtcctggcaaag	12	7	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:100667150G>C	uc004axv.1	-	5	1268	c.1191C>G	c.(1189-1191)TTC>TTG	p.F397L	C9orf156_uc004axw.1_Missense_Mutation_p.F294L|C9orf156_uc004axx.1_Missense_Mutation_p.F251L	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	397					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				CAGTAAAGTAGAAAAGGCGGT	0.527													0	0	0	0.139131	0	72	76										C	100667150	G	C	100667150	3	2	108	1	0	0	0	0	1	0	0	0	2465	933	33	1	138	1	C9orf156	9	100667150	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	49999	100667150	40546281	129	33007										
OR13C8	138802	broad.mit.edu	37	chr9	107332253	107332253	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgagtctaaagcctctgttGattcaggtaatgaagacatc	9	8	3	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:107332253G>A	uc011lvo.1	+	1	805	c.805G>A	c.(805-807)GAT>AAT	p.D269N		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGCCTCTGTTGATTCAGGTAA	0.453													0	0	0	0.086207	0	39	85										A	107332253	G	A	107332253	3	1	108	1	0	0	0	0	1	0	0	0	10938	1290	45	1	807	1	OR13C8	9	107332253	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	6665103	107332253	33881178	130	33008										
EXD3	54932	broad.mit.edu	37	chr9	140250821	140250821	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggtcacctcagggtaccgtCtgtggggagagagaggcaca	16	9	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr9:140250821C>G	uc004cmp.2	-	8	853	c.657_splice	c.e8-1	p.R219_splice	C9orf167_uc011mew.1_Intron|EXD3_uc010ncf.1_Splice_Site|EXD3_uc004cmq.1_Splice_Site|EXD3_uc010ncg.1_Splice_Site_p.R158_splice	NM_017820	NP_060290	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding				0						AGGGTACCGTCTGTGGGGAGA	0.438													0	0	0	0.021553	0	6	8										G	140250821	C	G	140250821	5	3	108	1	0	0	0	0	0	0	1	0	5299	927	32	1	2034	1	EXD3	9	140250821	Splice_Site	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	32918568	140250821	962610	131	33009										
ST8SIA6	338596	broad.mit.edu	37	chr10	17373460	17373460	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgggatttcttttttgctttCcacctcgtaactcatattag	6	9	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:17373460C>T	uc001ipd.2	-	5	469	c.469G>A	c.(469-471)GAA>AAA	p.E157K	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	157	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						TTTTTGCTTTCCACCTCGTAA	0.393													0	0	0	0.062417	0	22	63										T	17373460	C	T	17373460	3	4	108	1	0	0	0	0	1	0	0	0	15235	864	30	1	743	1	ST8SIA6	10	17373460	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		17373460	118161287	132	33010										
MLLT10	8028	broad.mit.edu	37	chr10	21962602	21962602	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gggctcaaacttctggcataGaagaagaaactgtaaaggaa	11	6	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:21962602G>A	uc001iqs.2	+	11	1723	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	MLLT10_uc001iqt.2_Missense_Mutation_p.E459K|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.E459K|MLLT10_uc001ira.2_5'UTR|MLLT10_uc001irb.2_RNA|MLLT10_uc001iqz.2_Missense_Mutation_p.E214K	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	459	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						TTCTGGCATAGAAGAAGAAAC	0.398			T	MLL|PICALM|CDK6	AL								0	0	0	0.139131	0	86	200										A	21962602	G	A	21962602	3	1	108	1	0	0	0	0	1	0	0	0	9626	943	33	1	1413	1	MLLT10	10	21962602	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4589142	21962602	113572145	133	33011										
C10orf68	79741	broad.mit.edu	37	chr10	33000562	33000562	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acatagctcatgatgaagaaTcaggtgaaaatcctatgctt	8	7	2	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:33000562T>A	uc001iwn.3	+	7	867	c.394T>A	c.(394-396)TCA>ACA	p.S132T	C10orf68_uc001iwl.1_Missense_Mutation_p.S140T|C10orf68_uc001iwm.1_Missense_Mutation_p.S108T|C10orf68_uc010qei.1_Missense_Mutation_p.S59T	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	132										skin(2)|ovary(1)	3						TGATGAAGAATCAGGTGAAAA	0.338													0	0	0	0.09319	0	11	57										A	33000562	T	A	33000562	3	1	108	1	0	0	0	0	1	0	0	0	1613	1435	50	5	412	5	C10orf68	10	33000562	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	11037960	33000562	102534185	134	33012										
ANKRD30A	91074	broad.mit.edu	37	chr10	37508817	37508817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aatatgaaaaagagaaagcaGaaacagaagtaagtatcaaa	8	3	1	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:37508817G>A	uc001iza.1	+	34	4108	c.4009G>A	c.(4009-4011)GAA>AAA	p.E1337K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1393						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						AGAGAAAGCAGAAACAGAAGT	0.279													0	0	0	0.115264	0	2	12										A	37508817	G	A	37508817	3	1	108	1	0	0	0	0	1	0	0	0	658	943	33	1	4143	1	ANKRD30A	10	37508817	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4508255	37508817	98025930	135	33013										
RET	5979	broad.mit.edu	37	chr10	43620387	43620387	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggacaaaaggccggtgtttgCggacatcagcaaagacctgg	14	9	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:43620387C>A	uc001jal.2	+	18	3186	c.2996C>A	c.(2995-2997)GCG>GAG	p.A999E	RET_uc001jak.1_Missense_Mutation_p.A999E|RET_uc010qez.1_Missense_Mutation_p.A745E	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	999	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CCGGTGTTTGCGGACATCAGC	0.557		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				1	0	4.4004e-07	0.083992	4.57955e-07	21	69										A	43620387	C	A	43620387	3	1	108	1	0	0	0	0	1	0	0	0	13235	768	27	4	3066	4	RET	10	43620387	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6111570	43620387	91914360	136	33014										
SYT15	83849	broad.mit.edu	37	chr10	46967428	46967428	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgctccagaggctgtacctGaaagatgaagtgctcgtcaa	11	10	1	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:46967428G>A	uc001jea.2	-	4	802	c.649C>T	c.(649-651)CAG>TAG	p.Q217*	SYT15_uc001jdz.2_Nonsense_Mutation_p.Q217*|SYT15_uc001jeb.2_Nonsense_Mutation_p.Q95*|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	217	Cytoplasmic (Potential).|C2 1.					integral to membrane|plasma membrane					0						GGCTGTACCTGAAAGATGAAG	0.602													0	0	0	0.02938	0	7	67										A	46967428	G	A	46967428	4	1	108	1	0	0	0	0	0	1	0	0	15468	1299	45	1	690	1	SYT15	10	46967428	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	3347041	46967428	88567319	137	33015										
MYOZ1	58529	broad.mit.edu	37	chr10	75391879	75391879	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gggcatctggaaggtcatgcGtttggaggccttctcatatc	13	9	3	0	rs149293567		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:75391879G>T	uc001jur.2	-	6	1074	c.709C>A	c.(709-711)CGC>AGC	p.R237S		NM_021245	NP_067068	Q9NP98	MYOZ1_HUMAN	myozenin 1	237					myofibril assembly	nucleus|pseudopodium	FATZ binding			ovary(2)	2	Prostate(51;0.0112)					AAGGTCATGCGTTTGGAGGCC	0.473													1	0	0.000673444	0.069234	0.000680095	11	60										T	75391879	G	T	75391879	3	4	108	1	0	0	0	0	1	0	0	0	10095	1145	40	4	194	4	MYOZ1	10	75391879	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	28424451	75391879	60142868	138	33016										
TRIM8	81603	broad.mit.edu	37	chr10	104404923	104404923	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cactcggtgtgcgacgtggaGatccgaaggaatgaaatccg	14	9	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:104404923G>T	uc001kvz.2	+	1	672	c.549G>T	c.(547-549)GAG>GAT	p.E183D		NM_030912	NP_112174	Q9BZR9	TRIM8_HUMAN	tripartite motif-containing 8	183	Potential.					cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GCGACGTGGAGATCCGAAGGA	0.587													1	0	1.33987e-11	0.069234	1.42339e-11	10	11										T	104404923	G	T	104404923	3	4	108	1	0	0	0	0	1	0	0	0	16545	933	33	3	551	3	TRIM8	10	104404923	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	29013044	104404923	31129824	139	33017										
C10orf79	80217	broad.mit.edu	37	chr10	105927390	105927390	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aaatagtactttaagacactCtgcttcaatcttcttttgct	4	9	4	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:105927390C>T	uc001kxw.2	-	22	2913	c.2797G>A	c.(2797-2799)GAG>AAG	p.E933K	C10orf79_uc009xxq.2_Missense_Mutation_p.E241K|C10orf79_uc001kxx.3_Missense_Mutation_p.E934K	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	933	Potential.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTAAGACACTCTGCTTCAATC	0.358													0	0	0	0.0333	0	17	40										T	105927390	C	T	105927390	3	4	108	1	0	0	0	0	1	0	0	0	1618	922	32	1	2268	1	C10orf79	10	105927390	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1522467	105927390	29607357	140	33018										
DMBT1	1755	broad.mit.edu	37	chr10	124348677	124348677	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tcaggacccattgtcctggaTgatgtgcgctgctcaggaca	12	11	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:124348677T>A	uc001lgk.1	+	17	2107	c.2001T>A	c.(1999-2001)GAT>GAA	p.D667E	DMBT1_uc001lgl.1_Missense_Mutation_p.D657E|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.D667E|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	667	SRCR 5.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTGTCCTGGATGATGTGCGCT	0.587													0	0	0	0.139131	0	110	94										A	124348677	T	A	124348677	3	1	108	1	0	0	0	0	1	0	0	0	4577	1461	51	5	2067	5	DMBT1	10	124348677	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	18421287	124348677	11186070	141	33019										
DMBT1	1755	broad.mit.edu	37	chr10	124402857	124402857	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taccaggaaaaggtggacgtCgtcctgggtcccatccagct	12	12	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:124402857C>T	uc001lgk.1	+	53	7291	c.7185C>T	c.(7183-7185)GTC>GTT	p.V2395V	DMBT1_uc001lgl.1_Silent_p.V2385V|DMBT1_uc001lgm.1_Silent_p.V1767V|DMBT1_uc009xzz.1_Silent_p.V2394V|DMBT1_uc010qtx.1_Silent_p.V1115V|DMBT1_uc009yab.1_Silent_p.V1098V|DMBT1_uc009yac.1_Silent_p.V689V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2395					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGGTGGACGTCGTCCTGGGTC	0.647													0	0	0	0.0333	0	17	41										T	124402857	C	T	124402857	2	4	108	1	0	0	0	0	0	0	0	1	4577	871	31	1		1	DMBT1	10	124402857	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	54180	124402857	11131890	142	33020										
TCERG1L	256536	broad.mit.edu	37	chr10	132891546	132891546	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caagtcggaacctctgatccCggccgtatttctctgcaaac	8	14	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr10:132891546C>A	uc001lkp.2	-	12	1726	c.1640G>T	c.(1639-1641)CGG>CTG	p.R547L		NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	547	FF 2.									large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CCTCTGATCCCGGCCGTATTT	0.443													1	0	0.000157383	0.038147	0.000160124	8	96										A	132891546	C	A	132891546	3	1	108	1	0	0	0	0	1	0	0	0	15683	652	23	4	124	4	TCERG1L	10	132891546	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	8488689	132891546	2643201	143	33021										
LSP1	4046	broad.mit.edu	37	chr11	1905742	1905742	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccctccagtaacagtgtgaaGaaatcccagccagacttgcc	8	14	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:1905742G>C	uc001lui.2	+	7	823	c.648G>C	c.(646-648)AAG>AAC	p.K216N	LSP1_uc001luj.2_Missense_Mutation_p.K344N|LSP1_uc001luk.2_Missense_Mutation_p.K154N|LSP1_uc001lul.2_Missense_Mutation_p.K154N|LSP1_uc001lum.2_Missense_Mutation_p.K154N	NM_002339	NP_002330	P33241	LSP1_HUMAN	lymphocyte-specific protein 1 isoform 1	216					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			large_intestine(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		ACAGTGTGAAGAAATCCCAGC	0.572													0	0	0	0.105934	0	14	43										C	1905742	G	C	1905742	3	2	108	1	0	0	0	0	1	0	0	0	9063	933	33	1	674	1	LSP1	11	1905742	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08		1905742	133100774	144	33022										
SPON1	10418	broad.mit.edu	37	chr11	14276159	14276159	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgatgggccctagtcccgacTggaacgtaggcttatctgca	12	11	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:14276159T>A	uc001mle.2	+	9	1514	c.976T>A	c.(976-978)TGG>AGG	p.W326R		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein	326	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding				0				Epithelial(150;0.00898)		TAGTCCCGACTGGAACGTAGG	0.542													0	0	0	0.132662	0	14	42										A	14276159	T	A	14276159	3	1	108	1	0	0	0	0	1	0	0	0	15081	1580	55	5	1005	5	SPON1	11	14276159	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	12370417	14276159	120730357	145	33023										
LDLRAD3	143458	broad.mit.edu	37	chr11	36248840	36248840	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctgtgctgctgtcccgcctGgtggtcctggaccaccccca	11	18	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:36248840G>A	uc001mwk.1	+	5	697	c.660G>A	c.(658-660)CTG>CTA	p.L220L	LDLRAD3_uc010rey.1_Silent_p.L171L|LDLRAD3_uc010rez.1_Silent_p.L99L|LDLRAD3_uc010rfa.1_Intron	NM_174902	NP_777562	Q86YD5	LRAD3_HUMAN	low density lipoprotein receptor class A domain	220	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1	all_lung(20;0.089)|Lung NSC(22;0.175)|all_epithelial(35;0.177)	all_hematologic(20;0.124)				TGTCCCGCCTGGTGGTCCTGG	0.627													0	0	0	0.045705	0	34	41										A	36248840	G	A	36248840	2	1	108	1	0	0	0	0	0	0	0	1	8707	1335	47	2		2	LDLRAD3	11	36248840	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	21972681	36248840	98757676	146	33024										
OR5D13	390142	broad.mit.edu	37	chr11	55541543	55541543	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	attgccatattcaatgaggtGagcagcctaattatcattct	7	8	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:55541543G>A	uc010ril.1	+	1	630	c.630G>A	c.(628-630)GTG>GTA	p.V210V		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TCAATGAGGTGAGCAGCCTAA	0.403													0	0	0	0.069288	0	24	124										A	55541543	G	A	55541543	2	1	108	1	0	0	0	0	0	0	0	1	11154	1277	45	1		1	OR5D13	11	55541543	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	19292703	55541543	79464973	147	33025										
GIF	2694	broad.mit.edu	37	chr11	59609985	59609985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggctatcggcaaggtcgcctCagagttcttctggcacagtg	13	11	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:59609985C>G	uc001noi.2	-	4	490	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	GIF_uc010rkz.1_3'UTR	NM_005142	NP_005133	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	148					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2						AAGGTCGCCTCAGAGTTCTTC	0.577													0	0	0	0.055883	0	22	61										G	59609985	C	G	59609985	3	3	108	1	0	0	0	0	1	0	0	0	6376	835	29	1	835	1	GIF	11	59609985	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	4068442	59609985	75396531	148	33026										
SLC22A25	387601	broad.mit.edu	37	chr11	62951183	62951183	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tacctccatggttaggatgtCttcagcattcttcattccat	6	11	4	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:62951183C>G	uc001nwr.1	-	5	937	c.937G>C	c.(937-939)GAC>CAC	p.D313H	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Missense_Mutation_p.D313H	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	313	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						GTTAGGATGTCTTCAGCATTC	0.438													0	0	0	0.139131	0	94	173										G	62951183	C	G	62951183	3	3	108	1	0	0	0	0	1	0	0	0	14454	913	32	1	726	1	SLC22A25	11	62951183	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3341198	62951183	72055333	149	33027										
SF1	7536	broad.mit.edu	37	chr11	64544068	64544068	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccattgtgtcttggttccagCggctcctcttccgcttctta	8	14	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:64544068C>T	uc001obb.1	-	2	439	c.62G>A	c.(61-63)CGC>CAC	p.R21H	SF1_uc010rnn.1_5'UTR|SF1_uc001oaz.1_Missense_Mutation_p.R146H|SF1_uc001oba.1_Missense_Mutation_p.R21H|SF1_uc001obc.1_Missense_Mutation_p.R21H|SF1_uc001obd.1_Missense_Mutation_p.R21H|SF1_uc001obe.1_5'UTR|SF1_uc010rno.1_5'UTR|SF1_uc001obf.2_Missense_Mutation_p.R21H	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	21				R->K: No effect.|R->A: Decreases interaction with U2AF2 and spliceosome assembly.	nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						TTGGTTCCAGCGGCTCCTCTT	0.428													0	0	0	0.09836	0	41	71										T	64544068	C	T	64544068	3	4	108	1	0	0	0	0	1	0	0	0	14145	768	27	2	2043	2	SF1	11	64544068	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1592885	64544068	70462448	150	33028										
PCNXL3	399909	broad.mit.edu	37	chr11	65393419	65393421	+	In_Frame_Del	DEL	CTT	CTT	-													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcactggctggggccgtgggCttcttcacacattacctgct							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:65393419_65393421delCTT	uc001oey.2	+	20	3273_3275	c.3273_3275delCTT	c.(3271-3276)GGCTTC>GGC	p.F1093del	PCNXL3_uc009yqn.2_In_Frame_Del_p.F53del|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1093	Helical; (Potential).					integral to membrane					0						GGGCCGTGGGCTTCTTCACACAT	0.606											OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						9	26	---	---								-	65393421	CTT	-	65393419	7	5	108	1	0	1	0	1	0	0	0	0	11593	784	28	0	3351	0	PCNXL3	11	65393419	In_Frame_Del	DEL	CTT	TCGA-GC-A3YS-01A-11D-A23M-08	849351	65393419	69613097	151	33029										
ADRBK1	156	broad.mit.edu	37	chr11	67051208	67051208	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtgaaagagagcccctttttCcgctccctggactggcagat	11	12	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:67051208C>T	uc009yrn.1	+	16	1625	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	453	Protein kinase.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCCCCTTTTTCCGCTCCCTGG	0.542													0	0	0	0.049695	0	20	80										T	67051208	C	T	67051208	2	4	108	1	0	0	0	0	0	0	0	1	343	854	30	1		1	ADRBK1	11	67051208	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1657789	67051208	67955308	152	33030										
ANKRD13D	338692	broad.mit.edu	37	chr11	67068616	67068616	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acctggcttccccgtcaaaaTtggtgagaggctgggcacag	13	11	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:67068616T>C	uc001okc.1	+	12	1479	c.968T>C	c.(967-969)ATT>ACT	p.I323T	ANKRD13D_uc001okd.1_Missense_Mutation_p.I410T|ANKRD13D_uc001oke.1_Missense_Mutation_p.I323T|ANKRD13D_uc001okg.1_Missense_Mutation_p.I106T|ANKRD13D_uc001okh.1_Missense_Mutation_p.I106T|ANKRD13D_uc001oki.1_Missense_Mutation_p.I60T|SSH3_uc001okj.2_5'Flank|SSH3_uc001okk.2_5'Flank|SSH3_uc001okl.2_5'Flank	NM_207354	NP_997237	Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	323										ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCCGTCAAAATTGGTGAGAGG	0.632													0	0	0	0.058154	0	10	35										C	67068616	T	C	67068616	3	2	108	1	0	0	0	0	1	0	0	0	644	1493	52	5	1271	5	ANKRD13D	11	67068616	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	17408	67068616	67937900	153	33031										
AQP11	282679	broad.mit.edu	37	chr11	77301521	77301521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcaagaatcccatccgagtcGacttgctcaaagcggtcatc	9	13	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:77301521G>A	uc001oyj.2	+	1	842	c.484G>A	c.(484-486)GAC>AAC	p.D162N	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	162						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			CATCCGAGTCGACTTGCTCAA	0.567													0	0	0	0.050027	0	35	76										A	77301521	G	A	77301521	3	1	108	1	0	0	0	0	1	0	0	0	823	1058	37	1	486	1	AQP11	11	77301521	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	10232905	77301521	57704995	154	33032										
DYNC2H1	79659	broad.mit.edu	37	chr11	103049829	103049829	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctctgaattctgttctggatGataatcgactgctgactatg	9	8	3	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:103049829G>T	uc001pho.2	+	39	6358	c.6214G>T	c.(6214-6216)GAT>TAT	p.D2072Y	DYNC2H1_uc001phn.1_Missense_Mutation_p.D2072Y|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2072	AAA 2 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TGTTCTGGATGATAATCGACT	0.388													1	0	5.50884e-06	0.09319	5.66109e-06	12	44										T	103049829	G	T	103049829	3	4	108	1	0	0	0	0	1	0	0	0	4846	1290	45	3	6368	3	DYNC2H1	11	103049829	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	25748308	103049829	31956687	155	33033										
HTR3A	3359	broad.mit.edu	37	chr11	113856847	113856847	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgggggtgctgccctactttCgggagttcagcatggaaagc	15	9	1	0	rs139246177		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:113856847C>T	uc010rxb.1	+	6	906	c.673C>T	c.(673-675)CGG>TGG	p.R225W	HTR3A_uc010rxa.1_Missense_Mutation_p.R225W|HTR3A_uc009yyx.2_Intron|HTR3A_uc010rxc.1_Missense_Mutation_p.R204W	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	219	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GCCCTACTTTCGGGAGTTCAG	0.478													0	0	0	0.139131	0	53	131										T	113856847	C	T	113856847	3	4	108	1	0	0	0	0	1	0	0	0	7444	875	31	1	721	1	HTR3A	11	113856847	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	10807018	113856847	21149669	156	33034										
DDX6	1656	broad.mit.edu	37	chr11	118625512	118625512	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaataggtttaatttctgttCccagctgctcctcaatactt	6	10	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:118625512C>T	uc001pub.2	-	13	1722	c.1361G>A	c.(1360-1362)GGA>GAA	p.G454E	DDX6_uc001pua.2_Missense_Mutation_p.G154E|DDX6_uc001puc.2_Missense_Mutation_p.G454E	NM_004397	NP_004388	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	454	Helicase C-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		AATTTCTGTTCCCAGCTGCTC	0.423			T	IGH@	B-NHL								0	0	0	0.134883	0	31	55										T	118625512	C	T	118625512	3	4	108	1	0	0	0	0	1	0	0	0	4377	855	30	1	94	1	DDX6	11	118625512	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	4768665	118625512	16381004	157	33035										
BCL9L	283149	broad.mit.edu	37	chr11	118779098	118779098	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgaaagggggcacccctgccTgggggttcttcagacttgag	15	10	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:118779098T>C	uc001pug.2	-	2	1258	c.293A>G	c.(292-294)CAG>CGG	p.Q98R	BCL9L_uc009zal.2_Missense_Mutation_p.Q93R	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	98					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		CACCCCTGCCTGGGGGTTCTT	0.647													0	0	0	0.116897	0	28	42										C	118779098	T	C	118779098	3	2	108	1	0	0	0	0	1	0	0	0	1382	1580	55	5	4234	5	BCL9L	11	118779098	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	153586	118779098	16227418	158	33036										
ETS1	2113	broad.mit.edu	37	chr11	128354726	128354726	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aatatgacctaccacgactgGtcctccccatgcacatgttg	7	14	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr11:128354726G>A	uc010sbs.1	-	5	1038	c.722C>T	c.(721-723)ACC>ATC	p.T241I	ETS1_uc001qej.2_Missense_Mutation_p.T285I|ETS1_uc009zch.2_Intron|ETS1_uc009zcg.2_Missense_Mutation_p.T241I	NM_005238	NP_005229	P14921	ETS1_HUMAN	v-ets erythroblastosis virus E26 oncogene	241				MCMGRTSR -> FLPPPLPP (in Ref. 6; AAA52409).	cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			lung(4)|central_nervous_system(1)|pleura(1)	6	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		ACCACGACTGGTCCTCCCCAT	0.418													0	0	0	0.076483	0	21	63										A	128354726	G	A	128354726	3	1	108	1	0	0	0	0	1	0	0	0	5275	1261	44	2	619	2	ETS1	11	128354726	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	9575628	128354726	6651790	159	33037										
LEPREL2	10536	broad.mit.edu	37	chr12	6948245	6948245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atggggtgtgggccgtgactCggggacggcgctgtgccctg	20	10	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:6948245C>T	uc001qra.1	+	16	2021	c.1987C>T	c.(1987-1989)CGG>TGG	p.R663W	LEPREL2_uc001qqz.1_Missense_Mutation_p.R470W|LEPREL2_uc001qrb.1_Missense_Mutation_p.R470W|GNB3_uc001qrc.2_5'Flank|GNB3_uc001qrd.2_5'Flank|GNB3_uc009zfe.2_5'Flank	NM_014262	NP_055077	Q8IVL6	P3H3_HUMAN	leprecan-like 2 precursor	663	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity				0					L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGCCGTGACTCGGGGACGGCG	0.677													0	0	0	0.021553	0	6	25										T	6948245	C	T	6948245	3	4	108	1	0	0	0	0	1	0	0	0	8731	875	31	1	2040	1	LEPREL2	12	6948245	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		6948245	126903650	160	33038										
TAS2R20	259295	broad.mit.edu	37	chr12	11150218	11150218	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gattggttactgcccaggcaTtagaaataaaaattattact	7	6	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:11150218T>A	uc001qzm.2	-	1	257	c.257A>T	c.(256-258)AAT>ATT	p.N86I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	86	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						TGCCCAGGCATTAGAAATAAA	0.343													0	0	0	0.139131	0	62	56										A	11150218	T	A	11150218	3	1	108	1	0	0	0	0	1	0	0	0	15568	1493	52	5	676	5	TAS2R20	12	11150218	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	4201973	11150218	122701677	161	33039										
PLEKHA5	54477	broad.mit.edu	37	chr12	19406895	19406895	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cataatgaaaggaaagtgacCtgcaaacatccagtcacagg	9	9	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:19406895C>T	uc001reb.2	+	4	335	c.249C>T	c.(247-249)ACC>ACT	p.T83T	PLEKHA5_uc010sie.1_Silent_p.T83T|PLEKHA5_uc001rea.2_Silent_p.T83T|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc010sif.1_5'UTR|PLEKHA5_uc010sig.1_5'UTR|PLEKHA5_uc010sih.1_5'UTR	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	83	WW 2.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GGAAAGTGACCTGCAAACATC	0.323													0	0	0	0.139131	0	109	79										T	19406895	C	T	19406895	2	4	108	1	0	0	0	0	0	0	0	1	12059	668	24	2		2	PLEKHA5	12	19406895	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	8256677	19406895	114445000	162	33040										
C12orf71	728858	broad.mit.edu	37	chr12	27235288	27235288	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaaggacccttggaaggtgcAtcttcccaggaggttgtgtc	14	9	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:27235288A>G	uc001rhq.2	-	1	168	c.129T>C	c.(127-129)GAT>GAC	p.D43D		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	43											0						TGGAAGGTGCATCTTCCCAGG	0.547													0	0	0	0.058154	0	9	43										G	27235288	A	G	27235288	2	3	108	1	0	0	0	0	0	0	0	1	1712	214	8	5		5	C12orf71	12	27235288	Silent	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	7828393	27235288	106616607	163	33041										
NELL2	4753	broad.mit.edu	37	chr12	45173749	45173749	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgtgagggcggtgactgcctGagcggtaatgcagtctgact	16	8	1	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:45173749G>C	uc001rog.2	-	4	987	c.392C>G	c.(391-393)TCA>TGA	p.S131*	NELL2_uc001rof.3_Nonsense_Mutation_p.S130*|NELL2_uc001roh.2_Nonsense_Mutation_p.S131*|NELL2_uc009zkd.2_Nonsense_Mutation_p.S130*|NELL2_uc010skz.1_Nonsense_Mutation_p.S181*|NELL2_uc010sla.1_Nonsense_Mutation_p.S154*|NELL2_uc001roi.1_Nonsense_Mutation_p.S131*|NELL2_uc010slb.1_Nonsense_Mutation_p.S130*|NELL2_uc001roj.2_Nonsense_Mutation_p.S131*	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	131	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GTGACTGCCTGAGCGGTAATG	0.468													0	0	0	0.116897	0	28	132										C	45173749	G	C	45173749	4	2	108	1	0	0	0	0	0	1	0	0	10334	1294	45	1	2126	1	NELL2	12	45173749	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	17938461	45173749	88678146	164	33042										
PLEKHA9	51054	broad.mit.edu	37	chr12	45567959	45567959	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tggagtgtggtagagcagctCagaggtgaaggctgcatttg	17	5	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:45567959C>G	uc001rom.1	-	3	727	c.190G>C	c.(190-192)GAG>CAG	p.E64Q	PLEKHA9_uc009zke.2_Missense_Mutation_p.E64Q	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		TAGAGCAGCTCAGAGGTGAAG	0.443													0	0	0	0.139131	0	50	154										G	45567959	C	G	45567959	3	3	108	1	0	0	0	0	1	0	0	0	12063	835	29	1	989	1	PLEKHA9	12	45567959	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	394210	45567959	88283936	165	33043										
AQP6	363	broad.mit.edu	37	chr12	50368531	50368531	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctgcacttgctccccagatCcacttcactggctgctccat	6	18	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:50368531C>T	uc001rvr.1	+	3	901	c.564C>T	c.(562-564)ATC>ATT	p.I188I	AQP6_uc001rvp.1_Silent_p.I14I|AQP6_uc001rvq.1_RNA	NM_001652	NP_001643	Q13520	AQP6_HUMAN	aquaporin 6	188	Helical; (Potential).				excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity				0						CTCCCCAGATCCACTTCACTG	0.607											OREG0021809	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.059317	0	33	21										T	50368531	C	T	50368531	2	4	108	1	0	0	0	0	0	0	0	1	830	845	30	1		1	AQP6	12	50368531	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	4800572	50368531	83483364	166	33044										
RACGAP1	29127	broad.mit.edu	37	chr12	50390835	50390835	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agtcatacctctccaatcttGacaggtgttcctatcagggt	8	11	4	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:50390835G>C	uc001rvt.2	-	12	1342	c.1032C>G	c.(1030-1032)GTC>GTG	p.V344V	RACGAP1_uc009zlm.1_Silent_p.V344V|RACGAP1_uc001rvs.2_Silent_p.V344V|RACGAP1_uc001rvu.2_Silent_p.V344V	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	344					blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						CTCCAATCTTGACAGGTGTTC	0.443													0	0	0	0.069288	0	22	78										C	50390835	G	C	50390835	2	2	108	1	0	0	0	0	0	0	0	1	12977	1277	45	1		1	RACGAP1	12	50390835	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	22304	50390835	83461060	167	33045										
DNAJC14	85406	broad.mit.edu	37	chr12	56216185	56216185	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccctctggtgcctggaatccGagaaccaaatgagatgtgat	11	10	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:56216185G>A	uc001shx.1	-	6	2074	c.1870C>T	c.(1870-1872)CGG>TGG	p.R624W	DNAJC14_uc001shu.1_Missense_Mutation_p.R624W|DNAJC14_uc009zob.1_Missense_Mutation_p.R624W	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	624					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CCTGGAATCCGAGAACCAAAT	0.453											OREG0021910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.0918	0	23	87										A	56216185	G	A	56216185	3	1	108	1	0	0	0	0	1	0	0	0	4633	1057	37	1	246	1	DNAJC14	12	56216185	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5825350	56216185	77635710	168	33046										
IKZF4	64375	broad.mit.edu	37	chr12	56427078	56427078	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccaatagcctcaccaaacgcAagcgttccacaccccagaag	6	17	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:56427078A>T	uc001sjb.1	+	8	1129	c.970A>T	c.(970-972)AAG>TAG	p.K324*	IKZF4_uc010sqa.1_Nonsense_Mutation_p.K277*|IKZF4_uc001sjc.1_Nonsense_Mutation_p.K324*|IKZF4_uc001sjd.1_Nonsense_Mutation_p.K222*|IKZF4_uc009zoi.1_Nonsense_Mutation_p.K279*|IKZF4_uc001sje.1_Nonsense_Mutation_p.K283*	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	324					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CACCAAACGCAAGCGTTCCAC	0.502													0	0	0	0.144211	0	26	247										T	56427078	A	T	56427078	4	4	108	1	0	0	0	0	0	1	0	0	7617	131	5	5	996	5	IKZF4	12	56427078	Nonsense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	210893	56427078	77424817	169	33047										
OS9	10956	broad.mit.edu	37	chr12	58110272	58110272	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agccagaggaccaggccccaGgaggggaggaggtgccggct	19	11	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:58110272G>C	uc001spj.2	+	8	1029	c.970G>C	c.(970-972)GGA>CGA	p.G324R	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.G324R|OS9_uc001spl.2_Missense_Mutation_p.G324R|OS9_uc001spm.2_Missense_Mutation_p.G324R|OS9_uc001spn.2_Missense_Mutation_p.G325R|OS9_uc010sry.1_Missense_Mutation_p.G292R|OS9_uc010srz.1_Missense_Mutation_p.G265R	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	324					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			CCAGGCCCCAGGAGGGGAGGA	0.597													0	0	0	0.115264	0	2	6										C	58110272	G	C	58110272	3	2	108	1	0	0	0	0	1	0	0	0	11272	1001	35	4	1000	4	OS9	12	58110272	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1683194	58110272	75741623	170	33048										
APPL2	55198	broad.mit.edu	37	chr12	105593247	105593247	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgtaaacagattcatcaacaGaaagtaattcttgctgggac	8	7	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:105593247G>A	uc001tlf.1	-	10	985	c.767C>T	c.(766-768)TCT>TTT	p.S256F	APPL2_uc010swt.1_Missense_Mutation_p.S213F|APPL2_uc001tlg.1_Missense_Mutation_p.S10F|APPL2_uc010swu.1_Missense_Mutation_p.S262F|APPL2_uc009zuq.2_Missense_Mutation_p.S213F	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	256	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTCATCAACAGAAAGTAATTC	0.473													0	0	0	0.092188	0	40	29										A	105593247	G	A	105593247	3	1	108	1	0	0	0	0	1	0	0	0	818	942	33	1	1275	1	APPL2	12	105593247	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	47482975	105593247	28258648	171	33049										
ACACB	32	broad.mit.edu	37	chr12	109702055	109702055	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggggaacctgatctctccgAcaaggaccgaaaggacctgg	13	11	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:109702055A>G	uc001tob.2	+	50	6925	c.6806A>G	c.(6805-6807)GAC>GGC	p.D2269G	ACACB_uc001toc.2_Missense_Mutation_p.D2269G|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.D935G	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2269	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GATCTCTCCGACAAGGACCGA	0.552											OREG0022102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.059317	0	33	123										G	109702055	A	G	109702055	3	3	108	1	0	0	0	0	1	0	0	0	107	275	10	5	7000	5	ACACB	12	109702055	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	4108808	109702055	24149840	172	33050										
UBE3B	89910	broad.mit.edu	37	chr12	109939197	109939197	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cttaacgagtcaatgcacttGatcaccaaacagctgcagtt	7	11	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:109939197G>A	uc001top.2	+	13	1743	c.1140G>A	c.(1138-1140)TTG>TTA	p.L380L	UBE3B_uc001toq.2_Silent_p.L380L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L380L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	380					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CAATGCACTTGATCACCAAAC	0.557													0	0	0	0.139131	0	111	76										A	109939197	G	A	109939197	2	1	108	1	0	0	0	0	0	0	0	1	16877	1281	45	1		1	UBE3B	12	109939197	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	237142	109939197	23912698	173	33051										
KNTC1	9735	broad.mit.edu	37	chr12	123024233	123024233	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttgcatttaggcatttgttcAgaaagctaacgatgaaaatc	8	6	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:123024233A>G	uc001ucv.2	+	5	540	c.377A>G	c.(376-378)CAG>CGG	p.Q126R	KNTC1_uc010taf.1_Missense_Mutation_p.Q126R	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	126					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GCATTTGTTCAGAAAGCTAAC	0.264													0	0	0	0.115264	0	3	1										G	123024233	A	G	123024233	3	3	108	1	0	0	0	0	1	0	0	0	8428	188	7	5	391	5	KNTC1	12	123024233	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	13085036	123024233	10827662	174	33052										
EP400	57634	broad.mit.edu	37	chr12	132502842	132502842	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgctgtctaagaaaaagataCcgcggaaactcatggaggaa	11	7	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr12:132502842C>T	uc001ujn.2	+	20	4233	c.4198C>T	c.(4198-4200)CCG>TCG	p.P1400S	EP400_uc001ujl.2_Missense_Mutation_p.P1399S|EP400_uc001ujm.2_Missense_Mutation_p.P1400S	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1436					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.R1400W(1)		central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAAAAAGATACCGCGGAAACT	0.502													0	0	0	0.134883	0	31	47										T	132502842	C	T	132502842	3	4	108	1	0	0	0	0	1	0	0	0	5149	507	18	2	4273	2	EP400	12	132502842	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	9478609	132502842	1349053	175	33053										
N6AMT2	221143	broad.mit.edu	37	chr13	21331724	21331724	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctggggtgtctcatcatctTccaaatcactcatttcacaa	6	12	6	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:21331724T>A	uc001uno.1	-	2	95	c.14A>T	c.(13-15)GAA>GTA	p.E5V	N6AMT2_uc009zzr.1_Missense_Mutation_p.E5V|N6AMT2_uc001unp.2_RNA	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	5							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		CTCATCATCTTCCAAATCACT	0.403													0	0	0	0.080935	0	11	79										A	21331724	T	A	21331724	3	1	108	1	0	0	0	0	1	0	0	0	10115	1783	62	5	646	5	N6AMT2	13	21331724	Missense_Mutation	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08		21331724	93838154	176	33054										
RNF17	56163	broad.mit.edu	37	chr13	25416223	25416223	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tagttgagcttttcgattctCttggtgctcctgaaatgact	9	8	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:25416223C>G	uc001upr.2	+	19	2568	c.2527C>G	c.(2527-2529)CTT>GTT	p.L843V	RNF17_uc010tdd.1_Missense_Mutation_p.L702V|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.L843V|RNF17_uc001ups.2_Missense_Mutation_p.L782V|RNF17_uc010aac.2_Missense_Mutation_p.L41V|RNF17_uc010aad.2_5'Flank	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	843					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTCGATTCTCTTGGTGCTCC	0.333													0	0	0	0.038147	0	7	70										G	25416223	C	G	25416223	3	3	108	1	0	0	0	0	1	0	0	0	13461	913	32	1	2601	1	RNF17	13	25416223	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	4084499	25416223	89753655	177	33055										
SMAD9	4093	broad.mit.edu	37	chr13	37439763	37439763	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agaatctgttcctgttatttGaagggtcggtgaacccatct	10	8	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:37439763G>C	uc001uvw.2	-	5	1257	c.914C>G	c.(913-915)TCA>TGA	p.S305*	SMAD9_uc001uvx.2_Nonsense_Mutation_p.S268*|SMAD9_uc010tep.1_Nonsense_Mutation_p.S98*	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	305	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		CCTGTTATTTGAAGGGTCGGT	0.453													0	0	0	0.076483	0	23	45										C	37439763	G	C	37439763	4	2	108	1	0	0	0	0	0	1	0	0	14764	1294	45	1	501	1	SMAD9	13	37439763	Nonsense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	12023540	37439763	77730115	178	33056										
LHFP	10186	broad.mit.edu	37	chr13	39918097	39918097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tatgggtagtgcttctgtttCttgcccgaaaagcaagccag	11	9	2	0	rs142420975		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:39918097C>G	uc001uxf.2	-	4	1090	c.579G>C	c.(577-579)AAG>AAC	p.K193N		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	193						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		GCTTCTGTTTCTTGCCCGAAA	0.557			T	HMGA2	lipoma								0	0	0	0.124865	0	45	43										G	39918097	C	G	39918097	3	3	108	1	0	0	0	0	1	0	0	0	8763	912	32	1	27	1	LHFP	13	39918097	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2478334	39918097	75251781	179	33057										
RB1	5925	broad.mit.edu	37	chr13	49037882	49037897	+	Frame_Shift_Del	DEL	ATGTATGGCATATGCA	ATGTATGGCATATGCA	-													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	actagattatgatgtgttccAtgtatggcatatgcaaagtg					rs137853296		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08			ATGTATGGCATATGCA	-	ATGTATGGCATATGCA	ATGTATGGCATATGCA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:49037882_49037897delATGTATGGCATATGCA	uc001vcb.2	+	21	2288_2303	c.2122_2137delATGTATGGCATATGCA	c.(2122-2139)ATGTATGGCATATGCAAAfs	p.M708fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	708_713	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(6)|p.I703_E737del(2)|p.C712_A727del(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATGTGTTCCATGTATGGCATATGCAAAGTGAAGAA	0.296		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)								8	36	---	---								-	49037897	ATGTATGGCATATGCA	-	49037882	7	5	108	1	0	1	0	1	0	0	0	0	13098	217	8	0	2204	0	RB1	13	49037882	Frame_Shift_Del	DEL	ATGTATGGCATATGCA	TCGA-GC-A3YS-01A-11D-A23M-08	9119785	49037882	66131996	180	33058										
PCDH8	5100	broad.mit.edu	37	chr13	53420180	53420180	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggagccgggagccgaggctcCgccgcccgccgccccgggcc	17	20	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:53420180C>T	uc001vhi.2	-	1	2595	c.2392G>A	c.(2392-2394)GGA>AGA	p.G798R	PCDH8_uc001vhj.2_Intron	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	798	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GCCGAGGCTccgccgcccgcc	0.637													0	0	0	0.009096	0	4	12										T	53420180	C	T	53420180	3	4	108	1	0	0	0	0	1	0	0	0	11517	661	23	2	832	2	PCDH8	13	53420180	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	4382298	53420180	61749698	181	33059										
DCT	1638	broad.mit.edu	37	chr13	95114445	95114445	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtggttgtagtcatccaagcTaagatttgtaataagattta	9	4	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:95114445T>A	uc001vlv.3	-	5	1291	c.864_splice	c.e5-1	p.S288_splice	DCT_uc010afh.2_Splice_Site_p.S288_splice	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1						epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TCATCCAAGCTAAGATTTGTA	0.239													0	0	0	0.047766	0	9	47										A	95114445	T	A	95114445	5	1	108	1	0	0	0	0	0	0	1	0	4304	1536	53	5	820	5	DCT	13	95114445	Splice_Site	SNP	T	TCGA-GC-A3YS-01A-11D-A23M-08	41694265	95114445	20055433	182	33060										
NALCN	259232	broad.mit.edu	37	chr13	101944717	101944717	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agacggtgaatatactagttCctgtcatgacagaggaggac	12	7	1	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:101944717C>G	uc001vox.1	-	8	989	c.800G>C	c.(799-801)GGA>GCA	p.G267A	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.G267A|NALCN_uc001vpa.2_Missense_Mutation_p.G267A	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	267	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATACTAGTTCCTGTCATGAC	0.433													0	0	0	0.076483	0	23	28										G	101944717	C	G	101944717	3	3	108	1	0	0	0	0	1	0	0	0	10148	869	30	1	4564	1	NALCN	13	101944717	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6830272	101944717	13225161	183	33061										
MCF2L	23263	broad.mit.edu	37	chr13	113729380	113729380	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	attgggaacaagcactacgcGgtagactccatccgcccaaa	9	13	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr13:113729380G>A	uc001vsu.2	+	11	1378	c.1356G>A	c.(1354-1356)GCG>GCA	p.A452A	MCF2L_uc001vsq.2_Silent_p.A452A|MCF2L_uc010tjr.1_Silent_p.A395A|MCF2L_uc001vsr.2_Silent_p.A399A|MCF2L_uc001vss.3_Silent_p.A393A|MCF2L_uc010tjs.1_Silent_p.A393A|MCF2L_uc001vst.1_Silent_p.A357A	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	425	Spectrin.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				AGCACTACGCGGTAGACTCCA	0.657													0	0	0	0.125774	0	28	62										A	113729380	G	A	113729380	2	1	108	1	0	0	0	0	0	0	0	1	9379	1103	39	2		2	MCF2L	13	113729380	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	11784663	113729380	1440498	184	33062										
RNASE4	6038	broad.mit.edu	37	chr14	21167916	21167916	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tcgggccatagcgagcactaGacgtgttgtcattgcctgtg	13	10	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:21167916G>C	uc001vxy.3	+	2	949	c.386G>C	c.(385-387)AGA>ACA	p.R129T	RNASE4_uc001vxx.3_RNA|RNASE4_uc001vya.2_Missense_Mutation_p.R129T	NM_002937	NP_002928	P34096	RNAS4_HUMAN	ribonuclease, RNase A family, 4 precursor	129					mRNA cleavage	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			central_nervous_system(1)	1	all_cancers(95;0.00304)		Epithelial(56;5.13e-07)|all cancers(55;4.73e-06)	GBM - Glioblastoma multiforme(265;0.0133)		GCGAGCACTAGACGTGTTGTC	0.527													0	0	0	0.139131	0	88	104										C	21167916	G	C	21167916	3	2	108	1	0	0	0	0	1	0	0	0	13406	942	33	1	388	1	RNASE4	14	21167916	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08		21167916	86181624	185	33063										
BAZ1A	11177	broad.mit.edu	37	chr14	35227931	35227931	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tggattttagaaacaagtttCaaaaaaggccagctgtcatc	8	7	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:35227931C>G	uc001wsk.2	-	25	4933	c.4365G>C	c.(4363-4365)TTG>TTC	p.L1455F	BAZ1A_uc001wsl.2_Missense_Mutation_p.L1423F	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1455	Bromo.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		AAACAAGTTTCAAAAAAGGCC	0.373													0	0	0	0.069288	0	24	62										G	35227931	C	G	35227931	3	3	108	1	0	0	0	0	1	0	0	0	1329	825	29	1	317	1	BAZ1A	14	35227931	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	14060015	35227931	72121609	186	33064										
ZFYVE26	23503	broad.mit.edu	37	chr14	68264823	68264823	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggcggctctgcagtccatctCtgcttcctgagcagctctga	11	14	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:68264823C>T	uc001xka.2	-	11	2295	c.2156G>A	c.(2155-2157)AGA>AAA	p.R719K	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.R719K|ZFYVE26_uc010tta.1_Missense_Mutation_p.R719K	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	719					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CAGTCCATCTCTGCTTCCTGA	0.557													0	0	0	0.139131	0	62	71										T	68264823	C	T	68264823	3	4	108	1	0	0	0	0	1	0	0	0	17665	913	32	1	5591	1	ZFYVE26	14	68264823	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	33036892	68264823	39084717	187	33065										
VASH1	22846	broad.mit.edu	37	chr14	77242405	77242405	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtacaagccgcccgccttccGcacgctcagcgagctcgtgc	11	18	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:77242405G>A	uc001xst.2	+	5	1631	c.701G>A	c.(700-702)CGC>CAC	p.R234H		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	234					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		CCCGCCTTCCGCACGCTCAGC	0.672													0	0	0	0.038147	0	7	19										A	77242405	G	A	77242405	3	1	108	1	0	0	0	0	1	0	0	0	17122	1087	38	2	719	2	VASH1	14	77242405	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	8977582	77242405	30107135	188	33066										
FLRT2	23768	broad.mit.edu	37	chr14	86089433	86089433	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgaacaacggcagcaacacAgcgtccagccatgagcagac	10	14	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:86089433A>G	uc001xvr.2	+	2	2342	c.1575A>G	c.(1573-1575)ACA>ACG	p.T525T	FLRT2_uc010atd.2_Silent_p.T525T	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	525	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GCAGCAACACAGCGTCCAGCC	0.577													0	0	0	0.055883	0	21	143										G	86089433	A	G	86089433	2	3	108	1	0	0	0	0	0	0	0	1	5939	175	7	5		5	FLRT2	14	86089433	Silent	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	8847028	86089433	21260107	189	33067										
MOAP1	64112	broad.mit.edu	37	chr14	93650482	93650482	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	accagcctgcagagcctcctCgatttctgccacactgcagc	8	17	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:93650482C>A	uc001ybj.2	-	3	476	c.106G>T	c.(106-108)GAG>TAG	p.E36*	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	36					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		agagcctcctcgatttctgcc	0													1	0	7.97055e-49	0.139131	8.90698e-49	122	147										A	93650482	C	A	93650482	4	1	108	1	0	0	0	0	0	1	0	0	9680	893	31	3	953	3	MOAP1	14	93650482	Nonsense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	7561049	93650482	13699058	190	33068										
BCL11B	64919	broad.mit.edu	37	chr14	99641436	99641436	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gccttggccgcgccgcccccCgcgcccgggaccccgggcac	14	23	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:99641436C>T	uc001yga.2	-	4	2004	c.1737G>A	c.(1735-1737)GCG>GCA	p.A579A	BCL11B_uc001ygb.2_Silent_p.A508A	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	579	Gly-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		cgccgccccccgcgcccggga	0.557			T	TLX3	T-ALL								0	0	0	0.047766	0	8	19										T	99641436	C	T	99641436	2	4	108	1	0	0	0	0	0	0	0	1	1364	639	23	2		2	BCL11B	14	99641436	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	5990954	99641436	7708104	191	33069										
HSP90AA1	3320	broad.mit.edu	37	chr14	102549376	102549376	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctgtattcacataccttttCaacttttttctccaatatgt	3	10	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr14:102549376C>T	uc001yku.3	-	9	1940	c.1750G>A	c.(1750-1752)GAA>AAA	p.E584K	HSP90AA1_uc001ykv.3_Missense_Mutation_p.E706K|HSP90AA1_uc001ykw.1_Missense_Mutation_p.E405K|HSP90AA1_uc001ykx.1_Missense_Mutation_p.E573K	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	584					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CATACCTTTTCAACTTTTTTC	0.194													0	0	0	0.050027	0	35	34										T	102549376	C	T	102549376	3	4	108	1	0	0	0	0	1	0	0	0	7401	835	29	1	460	1	HSP90AA1	14	102549376	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2907940	102549376	4800164	192	33070										
OR4N4	283694	broad.mit.edu	37	chr15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aatgatgttggctctgtggcINSttgggggttttgtccactcc							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:22382920_22382921insT	uc001yuc.1	+	7	1429_1430	c.448_449insT	c.(448-450)CTTfs	p.L150fs	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Frame_Shift_Ins_p.L150fs	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535																		23	132	---	---								T	22382921	-	T	22382920	7	5	108	1	0	1	1	0	0	0	0	0	11078	797	28	0	450	0	OR4N4	15	22382920	Frame_Shift_Ins	INS	-	TCGA-GC-A3YS-01A-11D-A23M-08		22382920	80148472	193	33071										
HERC2	8924	broad.mit.edu	37	chr15	28456214	28456214	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctgccgcagtttatcctggtGggagagcagcgcccgacctg	14	13	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:28456214G>T	uc001zbj.2	-	44	7109	c.7003C>A	c.(7003-7005)CAC>AAC	p.H2335N		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2335					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTATCCTGGTGGGAGAGCAGC	0.502													1	0	1.56452e-12	0.043863	1.67073e-12	19	116										T	28456214	G	T	28456214	3	4	108	1	0	0	0	0	1	0	0	0	7058	1348	47	4	7701	4	HERC2	15	28456214	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	6073294	28456214	74075178	194	33072										
SEMA6D	80031	broad.mit.edu	37	chr15	48057100	48057100	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtacagactgacggccatctCagtggaccattcagccggac	11	13	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:48057100C>T	uc010bek.2	+	13	1634	c.1274C>T	c.(1273-1275)TCA>TTA	p.S425L	SEMA6D_uc001zvw.2_Missense_Mutation_p.S425L|SEMA6D_uc001zvx.1_Missense_Mutation_p.S425L|SEMA6D_uc001zvy.2_Missense_Mutation_p.S425L|SEMA6D_uc001zvz.2_Missense_Mutation_p.S425L|SEMA6D_uc001zwa.2_Missense_Mutation_p.S425L|SEMA6D_uc001zwb.2_Missense_Mutation_p.S425L|SEMA6D_uc001zwc.2_Missense_Mutation_p.S425L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	425	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACGGCCATCTCAGTGGACCAT	0.512													0	0	0	0.055883	0	22	60										T	48057100	C	T	48057100	3	4	108	1	0	0	0	0	1	0	0	0	14042	838	29	1	1320	1	SEMA6D	15	48057100	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	19600886	48057100	54474292	195	33073										
ULK3	25989	broad.mit.edu	37	chr15	75134485	75134485	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggtatggatgaagcgagacaGgtcgccccctgcgcaaaact	13	11	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:75134485G>A	uc010bkf.1	-	3	401	c.295C>T	c.(295-297)CTG>TTG	p.L99L	ULK3_uc010ulp.1_Silent_p.L9L|ULK3_uc010ulq.1_Silent_p.L110L|ULK3_uc010ulr.1_Intron|ULK3_uc002ayv.2_Silent_p.L99L|ULK3_uc010uls.1_Intron|ULK3_uc010ult.1_Silent_p.L9L|ULK3_uc010ulu.1_Silent_p.L9L	NM_001099436	NP_001092906	Q6PHR2	ULK3_HUMAN	unc-51-like kinase 3	99	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						AAGCGAGACAGGTCGCCCCCT	0.547													0	0	0	0.014758	0	5	104										A	75134485	G	A	75134485	2	1	108	1	0	0	0	0	0	0	0	1	16974	991	35	2		2	ULK3	15	75134485	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	27077385	75134485	27396907	196	33074										
AEN	64782	broad.mit.edu	37	chr15	89173447	89173447	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acagacatggaacagtacatGgaggaccagtactggcccga	12	10	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr15:89173447G>A	uc002bmt.2	+	4	1051	c.900G>A	c.(898-900)ATG>ATA	p.M300I	AEN_uc010bnm.1_Missense_Mutation_p.M300I	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	300					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						AACAGTACATGGAGGACCAGT	0.647													0	0	0	0.014758	0	5	8										A	89173447	G	A	89173447	3	1	108	1	0	0	0	0	1	0	0	0	351	1348	47	2	910	2	AEN	15	89173447	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	14038962	89173447	13357945	197	33075										
GRIN2A	2903	broad.mit.edu	37	chr16	9857673	9857673	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	catcgatgtcatagaggttcCccatccgcaggcaggcatcg	11	13	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:9857673C>A	uc002czo.3	-	13	4276	c.3728G>T	c.(3727-3729)GGG>GTG	p.G1243V	GRIN2A_uc010uym.1_Missense_Mutation_p.G1243V|GRIN2A_uc010uyn.1_Missense_Mutation_p.G1086V|GRIN2A_uc002czr.3_Missense_Mutation_p.G1243V	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1243	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATAGAGGTTCCCCATCCGCAG	0.572													1	0	1.50372e-20	0.139131	1.63136e-20	68	52										A	9857673	C	A	9857673	3	1	108	1	0	0	0	0	1	0	0	0	6779	623	22	4	670	4	GRIN2A	16	9857673	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		9857673	80497080	198	33076										
NDE1	54820	broad.mit.edu	37	chr16	15758666	15758666	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccggaaagactttcagctccGaggaggaagaagctaactat	11	9	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:15758666G>A	uc002ddt.1	+	1	74	c.31G>A	c.(31-33)GAG>AAG	p.E11K	NDE1_uc010uzy.1_Missense_Mutation_p.E11K|NDE1_uc002dds.2_Missense_Mutation_p.E11K	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	11	Self-association (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						TTTCAGCTCCGAGGAGGAAGA	0.408													0	0	0	0.139131	0	46	98										A	15758666	G	A	15758666	3	1	108	1	0	0	0	0	1	0	0	0	10243	1059	37	1	33	1	NDE1	16	15758666	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5900993	15758666	74596087	199	33077										
XYLT1	64131	broad.mit.edu	37	chr16	17211827	17211827	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctctccttggcatcccagtCagtgccgacctgaaacaggg	10	15	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:17211827C>T	uc002dfa.2	-	11	2318	c.2233G>A	c.(2233-2235)GAC>AAC	p.D745N		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	745	Lumenal (Potential).			D->G: Abolishes enzyme activity but does not affect UDP-binding.|D->E: No effect.	glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						GCATCCCAGTCAGTGCCGACC	0.547													0	0	0	0.105934	0	11	56										T	17211827	C	T	17211827	3	4	108	1	0	0	0	0	1	0	0	0	17460	826	29	1	654	1	XYLT1	16	17211827	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1453161	17211827	73142926	200	33078										
KIAA0556	23247	broad.mit.edu	37	chr16	27761548	27761548	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atacattccttccgaggcgtGaaggacatcacaatgctgtt	9	10	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:27761548G>A	uc002dow.2	+	16	3291	c.3267G>A	c.(3265-3267)GTG>GTA	p.V1089V		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1089										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						TCCGAGGCGTGAAGGACATCA	0.502													0	0	0	0.086207	0	41	72										A	27761548	G	A	27761548	2	1	108	1	0	0	0	0	0	0	0	1	8183	1277	45	1		1	KIAA0556	16	27761548	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	10549721	27761548	62593205	201	33079										
ATXN2L	11273	broad.mit.edu	37	chr16	28840778	28840778	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aatgaggagaactacggtgtGaagactacctatgatagcag	12	6	0	5			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:28840778G>A	uc002drc.2	+	7	966	c.798G>A	c.(796-798)GTG>GTA	p.V266V	uc010vct.1_Intron|ATXN2L_uc010byl.1_Silent_p.V266V|ATXN2L_uc002drb.2_Silent_p.V266V|ATXN2L_uc002dqy.2_Silent_p.V266V|ATXN2L_uc002dra.2_Silent_p.V266V|ATXN2L_uc002dqz.2_Silent_p.V266V|ATXN2L_uc010vdb.1_Silent_p.V266V|ATXN2L_uc002dre.2_Silent_p.V266V|ATXN2L_uc002drf.2_Intron	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	266						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACTACGGTGTGAAGACTACCT	0.458													0	0	0	0.02938	0	6	58										A	28840778	G	A	28840778	2	1	108	1	0	0	0	0	0	0	0	1	1212	1277	45	1		1	ATXN2L	16	28840778	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1079230	28840778	61513975	202	33080										
SEZ6L2	26470	broad.mit.edu	37	chr16	29900017	29900017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cacgtccccatgggccggccGgggagggaagccacagctca	15	15	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:29900017G>A	uc002duq.3	-	6	1123	c.883C>T	c.(883-885)CGG>TGG	p.R295W	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.R225W|SEZ6L2_uc002dur.3_Missense_Mutation_p.R225W|SEZ6L2_uc002dus.3_Missense_Mutation_p.R181W|SEZ6L2_uc010vec.1_Missense_Mutation_p.R295W|SEZ6L2_uc010ved.1_Missense_Mutation_p.R251W	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	295	Sushi 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TGGGCCGGCCGGGGAGGGAAG	0.642													0	0	0	0.099896	0	23	30										A	29900017	G	A	29900017	3	1	108	1	0	0	0	0	1	0	0	0	14144	1115	39	2	1940	2	SEZ6L2	16	29900017	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1059239	29900017	60454736	203	33081										
STX4	6810	broad.mit.edu	37	chr16	31051055	31051055	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctcccacagaagaaagtcttGattgccatctgtgtgtccat	8	11	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:31051055G>C	uc002eal.2	+	10	1049	c.825G>C	c.(823-825)TTG>TTC	p.L275F	STX4_uc002eak.2_Missense_Mutation_p.L273F|STX4_uc002eam.2_Missense_Mutation_p.L197F|uc002ean.1_5'Flank	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	275	Cytoplasmic (Potential).|Interaction with CENPF (By similarity).				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						AGAAAGTCTTGATTGCCATCT	0.572													0	0	0	0.139131	0	80	181										C	31051055	G	C	31051055	3	2	108	1	0	0	0	0	1	0	0	0	15346	1281	45	1	863	1	STX4	16	31051055	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1151038	31051055	59303698	204	33082										
KARS	3735	broad.mit.edu	37	chr16	75670391	75670391	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcaacttcaccccctctcctCgaagatcatagaagatgagc	7	14	3	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:75670391C>T	uc002feq.2	-	4	491	c.443G>A	c.(442-444)CGA>CAA	p.R148Q	KARS_uc002fer.2_Missense_Mutation_p.R176Q|KARS_uc002fes.2_5'UTR|KARS_uc010cgz.2_5'UTR	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	148					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	CCCCTCTCCTCGAAGATCATA	0.453													0	0	0	0.09836	0	38	223										T	75670391	C	T	75670391	3	4	108	1	0	0	0	0	1	0	0	0	7980	884	31	1	1394	1	KARS	16	75670391	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	44619336	75670391	14684362	205	33083										
ADAMTS18	170692	broad.mit.edu	37	chr16	77356322	77356322	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggacattgcaaaaaaaaattCaaagttctcagccttgcagt	7	8	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:77356322C>G	uc002ffc.3	-	14	2493	c.2074G>C	c.(2074-2076)GAA>CAA	p.E692Q	ADAMTS18_uc010chc.1_Missense_Mutation_p.E280Q|ADAMTS18_uc002ffe.1_Missense_Mutation_p.E388Q	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	692	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AAAAAAAATTCAAAGTTCTCA	0.393													0	0	0	0.038395	0	17	102										G	77356322	C	G	77356322	3	3	108	1	0	0	0	0	1	0	0	0	263	835	29	1	1631	1	ADAMTS18	16	77356322	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1685931	77356322	12998431	206	33084										
CENPN	55839	broad.mit.edu	37	chr16	81045675	81045675	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gactgtaaatttccgacagaGaaaggaatctgtagttcagc	10	7	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:81045675G>A	uc002ffx.2	+	2	921	c.131G>A	c.(130-132)AGA>AAA	p.R44K	CENPN_uc002ffw.3_Missense_Mutation_p.R44K|CENPN_uc010vnl.1_Missense_Mutation_p.R44K|CENPN_uc010vnm.1_Missense_Mutation_p.R44K|CENPN_uc002ffy.3_Missense_Mutation_p.R44K	NM_001100624	NP_001094094	Q96H22	CENPN_HUMAN	centromere protein N isoform 2	44					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0						TTCCGACAGAGAAAGGAATCT	0.418													0	0	0	0.069234	0	11	79										A	81045675	G	A	81045675	3	1	108	1	0	0	0	0	1	0	0	0	3238	942	33	1	133	1	CENPN	16	81045675	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	3689353	81045675	9309078	207	33085										
PKD1L2	114780	broad.mit.edu	37	chr16	81194496	81194496	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tggctgtgtctttgtgaatgCcggggcagcaggatctgtga	16	7	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:81194496C>T	uc002fgh.1	-	22	3492	c.3492G>A	c.(3490-3492)CGG>CGA	p.R1164R	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1164	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTTGTGAATGCCGGGGCAGCA	0.562													0	0	0	0.009096	0	3	51										T	81194496	C	T	81194496	2	4	108	1	0	0	0	0	0	0	0	1	11965	726	26	2		2	PKD1L2	16	81194496	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	148821	81194496	9160257	208	33086										
ZC3H18	124245	broad.mit.edu	37	chr16	88644047	88644047	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaggggaaggctggtgttcaGagtgtgggagaaaaggaatc	19	3	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:88644047G>C	uc002fky.2	+	2	716	c.516G>C	c.(514-516)CAG>CAC	p.Q172H	ZC3H18_uc010voy.1_Intron|ZC3H18_uc010voz.1_Missense_Mutation_p.Q172H|ZC3H18_uc010vpa.1_Missense_Mutation_p.Q172H	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	172						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTGGTGTTCAGAGTGTGGGAG	0.557													0	0	0	0.058154	0	7	60										C	88644047	G	C	88644047	3	2	108	1	0	0	0	0	1	0	0	0	17565	933	33	1	518	1	ZC3H18	16	88644047	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	7449551	88644047	1710706	209	33087										
CDT1	81620	broad.mit.edu	37	chr16	88870299	88870299	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cgccccgggcccccccgcatCgcgccgcccaagctggcctg	12	23	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:88870299C>G	uc002flu.2	+	1	114	c.60C>G	c.(58-60)ATC>ATG	p.I20M		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	20	PIP-box K+4 motif.				DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		ccccccgcATCGCGCCGCCCA	0.572													0	0	0	0.115264	0	2	7										G	88870299	C	G	88870299	3	3	108	1	0	0	0	0	1	0	0	0	3180	874	31	1	62	1	CDT1	16	88870299	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	226252	88870299	1484454	210	33088										
TCF25	22980	broad.mit.edu	37	chr16	89952289	89952289	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aagatatcgatcgcatcctaGagaggattgaggacagcact	11	8	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr16:89952289G>C	uc002fpb.2	+	4	545	c.463G>C	c.(463-465)GAG>CAG	p.E155Q	TCF25_uc002fpc.2_5'UTR	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1	155					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TCGCATCCTAGAGAGGATTGA	0.458													0	0	0	0.139131	0	48	60										C	89952289	G	C	89952289	3	2	108	1	0	0	0	0	1	0	0	0	15690	943	33	1	477	1	TCF25	16	89952289	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1081990	89952289	402464	211	33089										
VPS53	55275	broad.mit.edu	37	chr17	556596	556596	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aagtgctccaggacattcatCacaccctgaaggagattagc	9	11	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:556596C>T	uc002frn.2	-	7	690	c.543G>A	c.(541-543)GTG>GTA	p.V181V	VPS53_uc002frk.2_Intron|VPS53_uc010cjo.1_Silent_p.V181V|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Silent_p.V152V|VPS53_uc002fro.2_5'UTR|VPS53_uc010cjp.1_Intron	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	181					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		GGACATTCATCACACCCTGAA	0.448													0	0	0	0.076483	0	23	265										T	556596	C	T	556596	2	4	108	1	0	0	0	0	0	0	0	1	17212	813	29	1		1	VPS53	17	556596	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		556596	80638614	212	33090										
P2RX5	5026	broad.mit.edu	37	chr17	3593444	3593444	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcctccttcaggaatggctcCctgaaaaccaacccagaaca	7	15	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:3593444C>T	uc002fwi.2	-	6	818	c.534G>A	c.(532-534)GAG>GAA	p.E178E	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Silent_p.E178E|P2RX5_uc010vrx.1_Silent_p.E118E|P2RX5_uc002fwj.2_Silent_p.E154E|P2RX5_uc002fwk.2_Silent_p.E178E|P2RX5_uc002fwl.2_Silent_p.E154E	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	178	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GGAATGGCTCCCTGAAAACCA	0.577													0	0	0	0.139131	0	50	190										T	3593444	C	T	3593444	2	4	108	1	0	0	0	0	0	0	0	1	11343	637	22	2		2	P2RX5	17	3593444	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3036848	3593444	77601766	213	33091										
ZNF232	7775	broad.mit.edu	37	chr17	5009425	5009425	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgatgctgaccgaggtttgaGctctgtttgaaagttttccc	11	8	1	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:5009425G>A	uc002gas.2	-	5	1702	c.948C>T	c.(946-948)AGC>AGT	p.S316S	ZNF232_uc002gar.1_Silent_p.S334S|ZNF232_uc002gat.2_Silent_p.S343S	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	316	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CGAGGTTTGAGCTCTGTTTGA	0.433													0	0	0	0.080935	0	11	206										A	5009425	G	A	5009425	2	1	108	1	0	0	0	0	0	0	0	1	17782	962	34	2		2	ZNF232	17	5009425	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1415981	5009425	76185785	214	33092										
TP53	7157	broad.mit.edu	37	chr17	7578457	7578457	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcttgtagatggccatggcgCggacgcgggtgccgggcggg	21	10	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.0333	0	17	25										T	7578457	C	T	7578457	3	4	108	1	0	0	0	0	1	0	0	0	16378	768	27	2	825	2	TP53	17	7578457	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2569032	7578457	73616753	215	33093										
C17orf68	80169	broad.mit.edu	37	chr17	8141719	8141719	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cttccacttacctcacagctCaggacgccagtgttatctct	6	15	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:8141719C>G	uc002gkq.3	-	3	485	c.426G>C	c.(424-426)CTG>CTC	p.L142L	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	142					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						CCTCACAGCTCAGGACGCCAG	0.488													0	0	0	0.074837	0	36	224										G	8141719	C	G	8141719	2	3	108	1	0	0	0	0	0	0	0	1	1876	813	29	1		1	C17orf68	17	8141719	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	563262	8141719	73053491	216	33094										
MYH13	8735	broad.mit.edu	37	chr17	10235464	10235464	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cggtccacatcgatggagttGaggagcttctctgaggcatt	13	9	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10235464G>T	uc002gmk.1	-	20	2340	c.2250C>A	c.(2248-2250)CTC>CTA	p.L750L		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	750	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CGATGGAGTTGAGGAGCTTCT	0.552													1	0	1.05317e-09	0.11911	1.11017e-09	14	130										T	10235464	G	T	10235464	2	4	108	1	0	0	0	0	0	0	0	1	10032	1277	45	3		3	MYH13	17	10235464	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	2093745	10235464	70959746	217	33095										
MYH1	4619	broad.mit.edu	37	chr17	10415489	10415489	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgcagagttcagattttggaGataggctgccttgtcagcaa	12	7	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10415489G>C	uc002gmo.2	-	13	1262	c.1168C>G	c.(1168-1170)CTC>GTC	p.L390V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	390	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AGATTTTGGAGATAGGCTGCC	0.453													0	0	0	0.139131	0	238	219										C	10415489	G	C	10415489	3	2	108	1	0	0	0	0	1	0	0	0	10029	942	33	1	4763	1	MYH1	17	10415489	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	180025	10415489	70779721	218	33096										
MYH3	4621	broad.mit.edu	37	chr17	10542949	10542949	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggtcatcaatgtctttcttGagctctgagcattcatcctc	7	11	6	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:10542949G>C	uc002gmq.1	-	22	2930	c.2853C>G	c.(2851-2853)CTC>CTG	p.L951L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	951	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGTCTTTCTTGAGCTCTGAGC	0.478													0	0	0	0.139131	0	117	297										C	10542949	G	C	10542949	2	2	108	1	0	0	0	0	0	0	0	1	10036	1277	45	1		1	MYH3	17	10542949	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	127460	10542949	70652261	219	33097										
LGALS9	3965	broad.mit.edu	37	chr17	25967659	25967659	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttgccttccacttcaaccctCggtttgaagatggagggtac	10	11	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:25967659C>T	uc002gzp.2	+	3	311	c.193C>T	c.(193-195)CGG>TGG	p.R65W	LGALS9_uc002gzq.2_Missense_Mutation_p.R65W|LGALS9_uc002gzr.2_Intron|LGALS9_uc010waa.1_Intron|LGALS9_uc002gzs.2_Missense_Mutation_p.R65W	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	65	Galectin 1.	Beta-galactoside 1.			positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		CTTCAACCCTCGGTTTGAAGA	0.537													0	0	0	0.139131	0	48	69										T	25967659	C	T	25967659	3	4	108	1	0	0	0	0	1	0	0	0	8748	875	31	1	203	1	LGALS9	17	25967659	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	15424710	25967659	55227551	220	33098										
SUPT6H	6830	broad.mit.edu	37	chr17	27000441	27000441	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgtctgattttgtggaaagcGaggctgaggagtcagaggaa	16	4	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:27000441G>A	uc002hby.2	+	2	112	c.22G>A	c.(22-24)GAG>AAG	p.E8K	SUPT6H_uc010crt.2_Missense_Mutation_p.E8K	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	8	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TGTGGAAAGCGAGGCTGAGGA	0.468													0	0	0	0.09319	0	9	36										A	27000441	G	A	27000441	3	1	108	1	0	0	0	0	1	0	0	0	15397	1059	37	1	24	1	SUPT6H	17	27000441	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1032782	27000441	54194769	221	33099										
MYO18A	399687	broad.mit.edu	37	chr17	27447636	27447636	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctgggcagcactctcacctGaatggaggctgaggccacct	12	14	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:27447636G>C	uc002hdt.1	-	7	1884	c.1726C>G	c.(1726-1728)CAG>GAG	p.Q576E	MYO18A_uc010wbc.1_Missense_Mutation_p.Q118E|MYO18A_uc002hds.2_Missense_Mutation_p.Q118E|MYO18A_uc010csa.1_Missense_Mutation_p.Q576E|MYO18A_uc002hdu.1_Missense_Mutation_p.Q576E|MYO18A_uc010wbd.1_Missense_Mutation_p.Q245E	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	576	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACTCTCACCTGAATGGAGGCT	0.562													0	0	0	0.132662	0	16	26										C	27447636	G	C	27447636	3	2	108	1	0	0	0	0	1	0	0	0	10065	1299	45	1	4582	1	MYO18A	17	27447636	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	447195	27447636	53747574	222	33100										
EFCAB5	374786	broad.mit.edu	37	chr17	28405274	28405274	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caaagccacaccctggtcacGaagtgagattgtcttcaaaa	8	11	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:28405274G>A	uc002het.2	+	15	2971	c.2779G>A	c.(2779-2781)GAA>AAA	p.E927K	EFCAB5_uc010cse.2_Missense_Mutation_p.E682K|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	927							calcium ion binding			ovary(1)|skin(1)	2						CCCTGGTCACGAAGTGAGATT	0.413													0	0	0	0.083992	0	25	71										A	28405274	G	A	28405274	3	1	108	1	0	0	0	0	1	0	0	0	4938	1059	37	1	3004	1	EFCAB5	17	28405274	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	957638	28405274	52789936	223	33101										
SPACA3	124912	broad.mit.edu	37	chr17	31324480	31324480	+	Missense_Mutation	SNP	C	C	T													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cagatttgttgaatcctaatCtcaaggataccgttatctgt							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:31324480C>T	uc002hhs.1	+	4	595	c.520C>T	c.(520-522)CTC>TTC	p.L174F	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	174	Extracellular (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			GAATCCTAATCTCAAGGATAC	0.413													0	0	0	0.139131	0	55	101										T	31324480	C	T	31324480	3	4	108	1	0	0	0	0	1	0	0	0	14973	913	32	1	534	1	SPACA3	17	31324480	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2919206	31324480	49870730	224	33102	165	2								
SPACA3	124912	broad.mit.edu	37	chr17	31324482	31324482	+	Silent	SNP	C	C	T													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gatttgttgaatcctaatctCaaggataccgttatctgtgc							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:31324482C>T	uc002hhs.1	+	4	597	c.522C>T	c.(520-522)CTC>CTT	p.L174L	SPACA3_uc010cte.1_RNA	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3	174	Extracellular (Potential).				cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			ATCCTAATCTCAAGGATACCG	0.413													0	0	0	0.139131	0	56	102										T	31324482	C	T	31324482	2	4	108	1	0	0	0	0	0	0	0	1	14973	813	29	1		1	SPACA3	17	31324482	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2	31324482	49870728	225	33103	165	2								
MYO19	80179	broad.mit.edu	37	chr17	34869487	34869487	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cttaccttctaagctcctctCtgggttgggcagccaggaga	11	12	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:34869487C>T	uc010wcy.1	-	11	1794	c.802G>A	c.(802-804)GAG>AAG	p.E268K	MYO19_uc002hmw.2_Missense_Mutation_p.E268K|MYO19_uc010cuu.2_RNA|MYO19_uc010wcz.1_RNA|MYO19_uc010wda.1_Missense_Mutation_p.E134K|MYO19_uc002hmx.2_Missense_Mutation_p.E268K	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	268	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGCTCCTCTCTGGGTTGGGC	0.602													0	0	0	0.038147	0	8	34										T	34869487	C	T	34869487	3	4	108	1	0	0	0	0	1	0	0	0	10067	922	32	1	2238	1	MYO19	17	34869487	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3545005	34869487	46325723	226	33104										
ERBB2	2064	broad.mit.edu	37	chr17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctttctacggacgtgggatCctgcaccctcgtctgccccc	9	18	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:37868208C>T	uc002hso.2	+	8	1167	c.929C>T	c.(928-930)TCC>TTC	p.S310F	ERBB2_uc002hsm.2_Missense_Mutation_p.S280F|ERBB2_uc010cwa.2_Missense_Mutation_p.S295F|ERBB2_uc002hsp.2_Missense_Mutation_p.S113F|ERBB2_uc010cwb.2_Missense_Mutation_p.S310F|ERBB2_uc010wek.1_Missense_Mutation_p.S34F|ERBB2_uc002hsl.2_Missense_Mutation_p.S280F|ERBB2_uc002hsn.1_Missense_Mutation_p.S310F	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	310	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(2)|p.S310Y(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.139131	0	101	153										T	37868208	C	T	37868208	3	4	108	1	0	0	0	0	1	0	0	0	5206	855	30	1	959	1	ERBB2	17	37868208	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2998721	37868208	43327002	227	33105										
WNK4	65266	broad.mit.edu	37	chr17	40939370	40939370	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cgtgaacgggttgctgccatCcagcgaaagcgtgagaagct	14	10	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:40939370C>A	uc002ibj.2	+	7	1572	c.1551C>A	c.(1549-1551)ATC>ATA	p.I517I	WNK4_uc010wgx.1_Silent_p.I181I|WNK4_uc002ibk.1_Silent_p.I289I|WNK4_uc010wgy.1_5'UTR	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	517					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTGCTGCCATCCAGCGAAAGC	0.617													1	0	6.04164e-23	0.045705	6.57189e-23	32	34										A	40939370	C	A	40939370	2	1	108	1	0	0	0	0	0	0	0	1	17377	845	30	3		3	WNK4	17	40939370	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3071162	40939370	40255840	228	33106										
DDX42	11325	broad.mit.edu	37	chr17	61869830	61869830	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atttaccttacattcctgctGaaaactcaccaactcgccag	4	14	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:61869830G>A	uc002jbu.2	+	4	537	c.280G>A	c.(280-282)GAA>AAA	p.E94K	DDX42_uc002jbv.2_Missense_Mutation_p.E94K|DDX42_uc002jbw.1_5'UTR	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	94					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						CATTCCTGCTGAAAACTCACC	0.418													0	0	0	0.139131	0	48	68										A	61869830	G	A	61869830	3	1	108	1	0	0	0	0	1	0	0	0	4362	1291	45	1	286	1	DDX42	17	61869830	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	20930460	61869830	19325380	229	33107										
ABCA9	10350	broad.mit.edu	37	chr17	66979930	66979930	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgtgccaggttcttcagcttCatctccagcaggtagtcttt	9	11	5	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:66979930C>T	uc002jhu.2	-	36	4703	c.4560G>A	c.(4558-4560)ATG>ATA	p.M1520I	ABCA9_uc010dez.2_Missense_Mutation_p.M1482I	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1520	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCTTCAGCTTCATCTCCAGCA	0.468													0	0	0	0.055883	0	21	78										T	66979930	C	T	66979930	3	4	108	1	0	0	0	0	1	0	0	0	39	826	29	1	330	1	ABCA9	17	66979930	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	5110100	66979930	14215280	230	33108										
FBF1	85302	broad.mit.edu	37	chr17	73924184	73924184	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cttggggtggttgggcagctCtcctttcccagggtcctttg	14	11	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:73924184C>T	uc002jqc.2	-	7	602	c.328G>A	c.(328-330)GAG>AAG	p.E110K	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E100K|FBF1_uc002jqd.1_Missense_Mutation_p.E110K	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	110											0						TTGGGCAGCTCTCCTTTCCCA	0.537													0	0	0	0.014758	0	5	38										T	73924184	C	T	73924184	3	4	108	1	0	0	0	0	1	0	0	0	5695	922	32	1	3165	1	FBF1	17	73924184	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6944254	73924184	7271026	231	33109										
TMC8	147138	broad.mit.edu	37	chr17	76134203	76134203	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	acggtcacctggatgggcctCttctactgccccctgctgcc	10	17	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76134203C>G	uc002jup.2	+	12	1849	c.1467C>G	c.(1465-1467)CTC>CTG	p.L489L	TMC8_uc002juq.2_Silent_p.L266L|TMC8_uc010wtr.1_Missense_Mutation_p.L195V|TMC8_uc002jur.1_5'UTR	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	489	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GGATGGGCCTCTTCTACTGCC	0.612									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.054565	0	34	61										G	76134203	C	G	76134203	2	3	108	1	0	0	0	0	0	0	0	1	15988	900	32	1		1	TMC8	17	76134203	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2210019	76134203	5061007	232	33110										
SYNGR2	9144	broad.mit.edu	37	chr17	76167089	76167089	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tatttcccccagatcagcaaCgccactgaccgcaagtacct	6	16	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76167089C>T	uc002juu.1	+	2	318	c.291C>T	c.(289-291)AAC>AAT	p.N97N	SYNGR2_uc002jut.2_Silent_p.N97N|SYNGR2_uc002juv.1_Silent_p.N97N|SYNGR2_uc010dhi.1_Intron	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	97	MARVEL.					integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			AGATCAGCAACGCCACTGACC	0.582													0	0	0	0.146539	0	17	65										T	76167089	C	T	76167089	2	4	108	1	0	0	0	0	0	0	0	1	15446	535	19	2		2	SYNGR2	17	76167089	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	32886	76167089	5028121	233	33111										
DNAH17	8632	broad.mit.edu	37	chr17	76445638	76445638	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tggcaggggtggtcctctggAtggctttctcaaacaccacg	13	11	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:76445638A>T	uc010dhp.1	-	14	2291	c.2069T>A	c.(2068-2070)ATC>AAC	p.I690N	DNAH17_uc002jvq.2_5'UTR|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTCCTCTGGATGGCTTTCTC	0.617													0	0	0	0.009096	0	4	11										T	76445638	A	T	76445638	3	4	108	1	0	0	0	0	1	0	0	0	4601	333	12	5	2371	5	DNAH17	17	76445638	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	278549	76445638	4749572	234	33112										
BAHCC1	57597	broad.mit.edu	37	chr17	79414364	79414364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcccactagaggggctacaaGaactgcaatgtgcggccctc	12	13	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr17:79414364G>A	uc002kaf.2	+	9	3466	c.3466G>A	c.(3466-3468)GAA>AAA	p.E1156K	BAHCC1_uc002kae.2_Missense_Mutation_p.E386K	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1156							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GGGGCTACAAGAACTGCAATG	0.697													0	0	0	0.115264	0	3	10										A	79414364	G	A	79414364	3	1	108	1	0	0	0	0	1	0	0	0	1296	943	33	1	3339	1	BAHCC1	17	79414364	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	2968726	79414364	1780846	235	33113										
ADCYAP1	116	broad.mit.edu	37	chr18	907685	907685	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggaagaggcgtacggcgagGacggaaacccgctgccagac	16	11	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:907685G>C	uc010dkg.2	+	3	255	c.136G>C	c.(136-138)GAC>CAC	p.D46H	ADCYAP1_uc010dkh.2_Missense_Mutation_p.D46H	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	46					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						GTACGGCGAGGACGGAAACCC	0.502													0	0	0	0.115264	0	2	5										C	907685	G	C	907685	3	2	108	1	0	0	0	0	1	0	0	0	302	1174	41	1	142	1	ADCYAP1	18	907685	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08		907685	77169563	236	33114										
SMCHD1	23347	broad.mit.edu	37	chr18	2732308	2732308	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agaagactattaagttgcttCccagtagccatgttgcaaga	9	8	0	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:2732308C>G	uc002klm.3	+	25	3283	c.3094C>G	c.(3094-3096)CCC>GCC	p.P1032A	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1032					chromosome organization		ATP binding				0						TAAGTTGCTTCCCAGTAGCCA	0.383													0	0	0	0.064281	0	35	95										G	2732308	C	G	2732308	3	3	108	1	0	0	0	0	1	0	0	0	14788	855	30	1	3192	1	SMCHD1	18	2732308	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1824623	2732308	75344940	237	33115										
SMCHD1	23347	broad.mit.edu	37	chr18	2732428	2732428	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttatgcataatcttatttttCaaatgtatgatgaaggagaa	7	3	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:2732428C>G	uc002klm.3	+	25	3403	c.3214C>G	c.(3214-3216)CAA>GAA	p.Q1072E	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1072					chromosome organization		ATP binding				0						TCTTATTTTTCAAATGTATGA	0.303													0	0	0	0.11911	0	13	36										G	2732428	C	G	2732428	3	3	108	1	0	0	0	0	1	0	0	0	14788	827	29	1	3312	1	SMCHD1	18	2732428	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	120	2732428	75344820	238	33116										
VAPA	9218	broad.mit.edu	37	chr18	9914267	9914267	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctctccgatggcgtccgcctCaggggccatggcgaagcacg	14	15	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:9914267C>T	uc002kok.2	+	1	313	c.14C>T	c.(13-15)TCA>TTA	p.S5L	VAPA_uc002koj.2_Missense_Mutation_p.S5L	NM_194434	NP_919415	Q9P0L0	VAPA_HUMAN	vesicle-associated membrane protein-associated	5	Cytoplasmic (Potential).				cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity				0						GCGTCCGCCTCAGGGGCCATG	0.597													0	0	0	0.009096	0	4	17										T	9914267	C	T	9914267	3	4	108	1	0	0	0	0	1	0	0	0	17118	838	29	1	16	1	VAPA	18	9914267	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	7181839	9914267	68162981	239	33117										
CTAGE1	64693	broad.mit.edu	37	chr18	19995722	19995722	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggtggggggaaaggaggtcCtcttcttatgaacgggcccc	16	9	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:19995722C>T	uc002ktv.1	-	1	2157	c.2053G>A	c.(2053-2055)GGA>AGA	p.G685R		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	685	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AAAGGAGGTCCTCTTCTTATG	0.507													0	0	0	0.139131	0	73	122										T	19995722	C	T	19995722	3	4	108	1	0	0	0	0	1	0	0	0	3992	690	24	2	188	2	CTAGE1	18	19995722	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	10081455	19995722	58081526	240	33118										
LAMA3	3909	broad.mit.edu	37	chr18	21399954	21399954	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aggatatgcccaaatgacctCagtacaggtacgcaacccga	9	12	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:21399954C>G	uc002kuq.2	+	19	2383	c.2297C>G	c.(2296-2298)TCA>TGA	p.S766*	LAMA3_uc002kur.2_Nonsense_Mutation_p.S766*	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	766					cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAATGACCTCAGTACAGGTA	0.527													0	0	0	0.047766	0	9	67										G	21399954	C	G	21399954	4	3	108	1	0	0	0	0	0	1	0	0	8607	838	29	1	2371	1	LAMA3	18	21399954	Nonsense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1404232	21399954	56677294	241	33119										
MOCOS	55034	broad.mit.edu	37	chr18	33800081	33800081	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggagctggatggttgtgaatCacaatggtgtttgcctgagt	15	5	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:33800081C>T	uc002kzq.3	+	9	1884	c.1861C>T	c.(1861-1863)CAC>TAC	p.H621Y		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	621					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GGTTGTGAATCACAATGGTGT	0.537													0	0	0	0.076483	0	23	30										T	33800081	C	T	33800081	3	4	108	1	0	0	0	0	1	0	0	0	9689	826	29	1	1895	1	MOCOS	18	33800081	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	12400127	33800081	44277167	242	33120										
ZNF236	7776	broad.mit.edu	37	chr18	74607060	74607060	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agcgacctggtccgccacatCcgcatccacacccacgagaa	8	18	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr18:74607060C>G	uc002lmi.2	+	10	1701	c.1503C>G	c.(1501-1503)ATC>ATG	p.I501M	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	501	C2H2-type 10.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TCCGCCACATCCGCATCCACA	0.647													0	0	0	0.11126	0	42	55										G	74607060	C	G	74607060	3	3	108	1	0	0	0	0	1	0	0	0	17786	845	30	1	1541	1	ZNF236	18	74607060	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	40806979	74607060	3470188	243	33121										
ZFR2	23217	broad.mit.edu	37	chr19	3819086	3819086	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tcggcggccccggtcctcctCggccagtgtgtcggacacca	13	17	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:3819086C>T	uc002lyw.2	-	12	1900	c.1888G>A	c.(1888-1890)GAG>AAG	p.E630K		NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	630						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CGGTCCTCCTCGGCCAGTGTG	0.687													0	0	0	0.02938	0	5	21										T	3819086	C	T	3819086	3	4	108	1	0	0	0	0	1	0	0	0	17657	893	31	1	963	1	ZFR2	19	3819086	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		3819086	55309897	244	33122										
ZBTB7A	51341	broad.mit.edu	37	chr19	4048230	4048230	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgcttccgcatgtgcaccttCagcttgtcctgcctgtggac	10	14	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:4048230C>T	uc002lzh.2	-	3	1350	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	ZBTB7A_uc002lzi.2_Silent_p.L425L	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	425	C2H2-type 2.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCACCTTCAGCTTGTCCT	0.697													0	0	0	0.09319	0	11	21										T	4048230	C	T	4048230	2	4	108	1	0	0	0	0	0	0	0	1	17550	813	29	1		1	ZBTB7A	19	4048230	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	229144	4048230	55080753	245	33123										
ZBTB7A	51341	broad.mit.edu	37	chr19	4054074	4054074	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctggatgaccttctcgcagAtggggcacttctggaaggcc	13	12	2	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:4054074A>T	uc002lzh.2	-	2	1232	c.1157T>A	c.(1156-1158)ATC>AAC	p.I386N	ZBTB7A_uc002lzi.2_Missense_Mutation_p.I386N	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	386	C2H2-type 1.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTCGCAGATGGGGCACTT	0.637													0	0	0	0.045705	0	29	43										T	4054074	A	T	4054074	3	4	108	1	0	0	0	0	1	0	0	0	17550	333	12	5	605	5	ZBTB7A	19	4054074	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	5844	4054074	55074909	246	33124										
KIAA1543	57662	broad.mit.edu	37	chr19	7682676	7682676	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gccaaccacttcctgatcctCtttcgcgactcgagctgcca	7	17	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:7682676C>G	uc002mgv.3	+	17	3584	c.3483C>G	c.(3481-3483)CTC>CTG	p.L1161L	KIAA1543_uc002mgu.3_Silent_p.L1188L|KIAA1543_uc002mgw.2_Silent_p.L291L	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	1161	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						TCCTGATCCTCTTTCGCGACT	0.637													0	0	0	0.043863	0	19	40										G	7682676	C	G	7682676	2	3	108	1	0	0	0	0	0	0	0	1	8243	900	32	1		1	KIAA1543	19	7682676	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	3628602	7682676	51446307	247	33125										
MUC16	94025	broad.mit.edu	37	chr19	9015637	9015637	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	taaccagactctgcaggactCtctctgtggtgttgaacttc	9	11	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:9015637C>G	uc002mkp.2	-	29	38390	c.38186G>C	c.(38185-38187)AGA>ACA	p.R12729T	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12731	SEA 5.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCAGGACTCTCTCTGTGGT	0.532													0	0	0	0.099896	0	26	150										G	9015637	C	G	9015637	3	3	108	1	0	0	0	0	1	0	0	0	9973	913	32	1	5561	1	MUC16	19	9015637	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1332961	9015637	50113346	248	33126										
MUC16	94025	broad.mit.edu	37	chr19	9076183	9076183	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctggggagttgtggccccctGaggagctgaggtagtggctg	19	8	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:9076183G>C	uc002mkp.2	-	3	11467	c.11263C>G	c.(11263-11265)CAG>GAG	p.Q3755E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3756	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGCCCCCTGAGGAGCTGAG	0.522													0	0	0	0.144211	0	30	138										C	9076183	G	C	9076183	3	2	108	1	0	0	0	0	1	0	0	0	9973	1299	45	1	32588	1	MUC16	19	9076183	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	60546	9076183	50052800	249	33127										
TYK2	7297	broad.mit.edu	37	chr19	10488945	10488945	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gctgtcagcgatgactcactGaaagtgacccagggctcccc	11	14	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:10488945G>A	uc002moc.3	-	3	516	c.138C>T	c.(136-138)TTC>TTT	p.F46F	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.F46F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	46	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ATGACTCACTGAAAGTGACCC	0.622													0	0	0	0.134883	0	29	45										A	10488945	G	A	10488945	2	1	108	1	0	0	0	0	0	0	0	1	16807	1281	45	1		1	TYK2	19	10488945	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1412762	10488945	48640038	250	33128										
ILF3	3609	broad.mit.edu	37	chr19	10793282	10793282	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gcaagggggaggactcggctGaggagaccgaggcgaagcca	19	9	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:10793282G>A	uc002mpn.2	+	13	1767	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	ILF3_uc002mpm.2_Missense_Mutation_p.E484K|ILF3_uc002mpl.2_Missense_Mutation_p.E484K|ILF3_uc002mpk.2_Missense_Mutation_p.E484K|ILF3_uc010xli.1_Missense_Mutation_p.E82K|ILF3_uc002mpo.2_Missense_Mutation_p.E484K|ILF3_uc002mpp.2_Missense_Mutation_p.E305K	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	484					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGACTCGGCTGAGGAGACCGA	0.647													0	0	0	0.058154	0	9	33										A	10793282	G	A	10793282	3	1	108	1	0	0	0	0	1	0	0	0	7712	1291	45	1	1496	1	ILF3	19	10793282	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	304337	10793282	48335701	251	33129										
MAST1	22983	broad.mit.edu	37	chr19	12975882	12975882	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tccttatcacctccatgggtCacatcaagctcacagatttc	5	14	4	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:12975882C>T	uc002mvm.2	+	14	1656	c.1528C>T	c.(1528-1530)CAC>TAC	p.H510Y		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	510	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CTCCATGGGTCACATCAAGCT	0.577													0	0	0	0.069234	0	9	82										T	12975882	C	T	12975882	3	4	108	1	0	0	0	0	1	0	0	0	9324	826	29	1	1582	1	MAST1	19	12975882	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2182600	12975882	46153101	252	33130										
CYP4F11	57834	broad.mit.edu	37	chr19	16038102	16038102	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaaggcaggcgtcaacatccGacggtggcggctccacttgt	14	12	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:16038102G>A	uc002nbu.2	-	5	481	c.445C>T	c.(445-447)CGG>TGG	p.R149W	CYP4F11_uc010eab.1_Missense_Mutation_p.R149W|CYP4F11_uc002nbt.2_Missense_Mutation_p.R149W	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	149					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						GTCAACATCCGACGGTGGCGG	0.537													0	0	0	0.058154	0	10	131										A	16038102	G	A	16038102	3	1	108	1	0	0	0	0	1	0	0	0	4186	1057	37	1	1165	1	CYP4F11	19	16038102	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	3062220	16038102	43090881	253	33131										
ZNF714	148206	broad.mit.edu	37	chr19	21300143	21300143	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ataagatgattcatactggaGagaaaccctacagatgtgaa	9	6	1	5			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:21300143G>C	uc002npo.3	+	6	1036	c.676G>C	c.(676-678)GAG>CAG	p.E226Q	ZNF714_uc002npl.2_Missense_Mutation_p.E71Q|ZNF714_uc010ecp.1_Missense_Mutation_p.E177Q|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATACTGGAGAGAAACCCTA	0.408													0	0	0	0.014758	0	5	68										C	21300143	G	C	21300143	3	2	108	1	0	0	0	0	1	0	0	0	18115	943	33	1	683	1	ZNF714	19	21300143	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5262041	21300143	37828840	254	33132										
RBM42	79171	broad.mit.edu	37	chr19	36128214	36128214	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tacggcttcgtcagcttcaaGgaccccagcgactacgtgcg	11	14	2	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:36128214G>A	uc002oan.2	+	9	1366	c.1290G>A	c.(1288-1290)AAG>AAA	p.K430K	RBM42_uc010eef.2_Silent_p.K376K|RBM42_uc002oao.2_Silent_p.K408K|RBM42_uc002oap.2_Silent_p.K400K|RBM42_uc002oaq.2_Silent_p.K401K|RBM42_uc010eeg.2_Intron	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	430	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCAGCTTCAAGGACCCCAGCG	0.647													0	0	0	0.139131	0	91	112										A	36128214	G	A	36128214	2	1	108	1	0	0	0	0	0	0	0	1	13136	991	35	2		2	RBM42	19	36128214	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	14828071	36128214	23000769	255	33133										
ZNF569	148266	broad.mit.edu	37	chr19	37916855	37916855	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aaaatcacatcaggtttggtGaacggatagcctgtcaaagg	11	7	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:37916855G>A	uc002ogi.2	-	5	711	c.153C>T	c.(151-153)TTC>TTT	p.F51F	ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Silent_p.F75F	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGGTTTGGTGAACGGATAGC	0.443													0	0	0	0.139131	0	58	774										A	37916855	G	A	37916855	2	1	108	1	0	0	0	0	0	0	0	1	17997	1281	45	1		1	ZNF569	19	37916855	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	1788641	37916855	21212128	256	33134										
MEGF8	1954	broad.mit.edu	37	chr19	42873014	42873014	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gggctgacatgtgggcgtccGggggcctcctgggccttcct	17	13	0	1	rs145990797		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:42873014G>A	uc002otl.3	+	36	6935	c.6300G>A	c.(6298-6300)CCG>CCA	p.P2100P	MEGF8_uc002otm.3_Silent_p.P1708P|MEGF8_uc002otn.3_5'Flank	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2167	Extracellular (Potential).|PSI 7.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				GTGGGCGTCCGGGGGCCTCCT	0.642													0	0	0	0.139131	0	68	31										A	42873014	G	A	42873014	2	1	108	1	0	0	0	0	0	0	0	1	9463	1103	39	2		2	MEGF8	19	42873014	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	4956159	42873014	16255969	257	33135										
PSG6	5675	broad.mit.edu	37	chr19	43585239	43585239	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atgatgtaatgtaatggtagAggtccctgatttgccctttg	11	6	0	3	rs142667584		TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:43585239A>T	uc002ovi.2	-	2	317	c.224T>A	c.(223-225)CTC>CAC	p.L75H	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.L75H|PSG2_uc002ovq.3_Missense_Mutation_p.L75H|PSG2_uc010eiq.1_Missense_Mutation_p.L75H|PSG2_uc002ovs.3_Missense_Mutation_p.L75H|PSG2_uc002ovt.3_Missense_Mutation_p.L75H			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	75	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GTAATGGTAGAGGTCCCTGAT	0.433													0	0	0	0.11126	0	33	346										T	43585239	A	T	43585239	3	4	108	1	0	0	0	0	1	0	0	0	12659	304	11	5		5	PSG6	19	43585239	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	712225	43585239	15543744	258	33136										
XRCC1	7515	broad.mit.edu	37	chr19	44057007	44057007	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggtggtttgctgggggtcttCttttcttcttggttcaaatc	12	7	5	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:44057007C>G	uc002owt.2	-	8	885	c.765G>C	c.(763-765)AAG>AAC	p.K255N	XRCC1_uc010xwp.1_Missense_Mutation_p.K224N	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	255					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGGGGGTCTTCTTTTCTTCTT	0.498								Other_BER_factors					0	0	0	0.115264	0	3	43										G	44057007	C	G	44057007	3	3	108	1	0	0	0	0	1	0	0	0	17449	912	32	1	1176	1	XRCC1	19	44057007	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	471768	44057007	15071976	259	33137										
NANOS2	339345	broad.mit.edu	37	chr19	46417599	46417599	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggtagagggactgctggccaCcgttaagcgggcagtacttg	16	9	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:46417599C>T	uc002pdu.2	-	1	438	c.353G>A	c.(352-354)GGT>GAT	p.G118D		NM_001029861	NP_001025032	P60321	NANO2_HUMAN	nanos homolog 2	118					germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding				0		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		CTGCTGGCCACCGTTAAGCGG	0.672													0	0	0	0.055883	0	21	23										T	46417599	C	T	46417599	3	4	108	1	0	0	0	0	1	0	0	0	10152	507	18	2	67	2	NANOS2	19	46417599	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2360592	46417599	12711384	260	33138										
SAE1	10055	broad.mit.edu	37	chr19	47706939	47706939	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ctcttttaggtactgcttctCcgagatggccccagtgtgtg	11	11	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:47706939C>T	uc002pgc.2	+	8	946	c.890C>T	c.(889-891)TCC>TTC	p.S297F	SAE1_uc002pgd.2_Missense_Mutation_p.P249S|SAE1_uc010ekx.2_Intron|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_Missense_Mutation_p.S123F|SAE1_uc002pge.2_Missense_Mutation_p.S233F	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	297					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TACTGCTTCTCCGAGATGGCC	0.463													0	0	0	0.139131	0	78	42										T	47706939	C	T	47706939	3	4	108	1	0	0	0	0	1	0	0	0	13805	855	30	1	920	1	SAE1	19	47706939	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1289340	47706939	11422044	261	33139										
MEIS3	56917	broad.mit.edu	37	chr19	47910626	47910626	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	caccagttgttgacttgcagGatggtgagccccgtgtcctg	13	11	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:47910626G>T	uc002pgu.2	-	9	1365	c.918C>A	c.(916-918)ATC>ATA	p.I306I	MEIS3_uc010xyp.1_RNA|MEIS3_uc002pgo.2_Silent_p.I105I|MEIS3_uc002pgp.2_Silent_p.I138I|MEIS3_uc002pgq.2_Silent_p.I387I|MEIS3_uc002pgr.2_Silent_p.I174I|MEIS3_uc002pgt.2_Silent_p.I289I|MEIS3_uc002pgv.2_Silent_p.I335I|MEIS3_uc002pgs.2_Silent_p.I352I|MEIS3_uc010eld.2_Silent_p.I352I	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	306	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		TGACTTGCAGGATGGTGAGCC	0.597													1	0	3.95532e-38	0.139131	4.38408e-38	59	29										T	47910626	G	T	47910626	2	4	108	1	0	0	0	0	0	0	0	1	9469	1164	41	3		3	MEIS3	19	47910626	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	203687	47910626	11218357	262	33140										
SCAF1	58506	broad.mit.edu	37	chr19	50154733	50154733	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggaccgaggcagaggcttgtCgggaaggcaaggtctcggtg	19	8	1	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:50154733C>T	uc002poq.2	+	7	1211	c.1087C>T	c.(1087-1089)CGG>TGG	p.R363W		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	363					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		AGAGGCTTGTCGGGAAGGCAA	0.721													0	0	0	0.021553	0	4	7										T	50154733	C	T	50154733	3	4	108	1	0	0	0	0	1	0	0	0	13868	875	31	1	1109	1	SCAF1	19	50154733	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2244107	50154733	8974250	263	33141										
C19orf51	352909	broad.mit.edu	37	chr19	55676784	55676784	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tccagggctaggctgaagatCagcatgtgtcgggccacagc	14	11	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:55676784C>T	uc002qji.1	-	4	310	c.276G>A	c.(274-276)CTG>CTA	p.L92L	C19orf51_uc002qjj.1_Silent_p.L139L|C19orf51_uc002qjk.1_Silent_p.L38L|C19orf51_uc002qjl.1_Silent_p.L160L			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	92											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GGCTGAAGATCAGCATGTGTC	0.547													0	0	0	0.139131	0	43	21										T	55676784	C	T	55676784	2	4	108	1	0	0	0	0	0	0	0	1	1933	813	29	1		1	C19orf51	19	55676784	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	5522051	55676784	3452199	264	33142										
TMEM150B	284417	broad.mit.edu	37	chr19	55831502	55831502	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tctgacgccccagtcccggaGctggtggtaacggacaatgc	13	13	1	1	rs61737281	by1000genomes	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:55831502G>A	uc010esw.1	-	6	402	c.229C>T	c.(229-231)CTC>TTC	p.L77F	TMEM150B_uc010yfu.1_Missense_Mutation_p.L77F|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA|TMEM150B_uc002qki.2_Missense_Mutation_p.L77F	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	77	Cytoplasmic (Potential).					integral to membrane					0						CAGTCCCGGAGCTGGTGGTAA	0.612													0	0	0	0.021553	0	5	149										A	55831502	G	A	55831502	3	1	108	1	0	0	0	0	1	0	0	0	16065	971	34	2	484	2	TMEM150B	19	55831502	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	154718	55831502	3297481	265	33143										
NLRP4	147945	broad.mit.edu	37	chr19	56392885	56392885	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cccaggcacttctgacggctGaggaagagagaaatcctaac	11	11	1	4			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:56392885G>C	uc002qmd.3	+	10	3339	c.2917G>C	c.(2917-2919)GAG>CAG	p.E973Q	NLRP4_uc002qmf.2_Missense_Mutation_p.E898Q|NLRP4_uc010etf.2_Missense_Mutation_p.E748Q	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	973							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCTGACGGCTGAGGAAGAGAG	0.433													0	0	0	0.144211	0	32	21										C	56392885	G	C	56392885	3	2	108	1	0	0	0	0	1	0	0	0	10479	1291	45	1	2951	1	NLRP4	19	56392885	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	561383	56392885	2736098	266	33144										
PEG3	5178	broad.mit.edu	37	chr19	57327167	57327167	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttcttactgcccccttcacaAgggttctctctggcaggaat	8	13	4	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:57327167A>G	uc002qnu.2	-	7	2994	c.2643T>C	c.(2641-2643)CCT>CCC	p.P881P	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.P852P|PEG3_uc002qnv.2_Silent_p.P881P|PEG3_uc002qnw.2_Silent_p.P757P|PEG3_uc002qnx.2_Silent_p.P755P|PEG3_uc010etr.2_Silent_p.P881P	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	881					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCCCTTCACAAGGGTTCTCTC	0.443													0	0	0	0.069288	0	24	110										G	57327167	A	G	57327167	2	3	108	1	0	0	0	0	0	0	0	1	11720	59	3	5		5	PEG3	19	57327167	Silent	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	934282	57327167	1801816	267	33145										
ZNF587	84914	broad.mit.edu	37	chr19	58371262	58371262	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggagaaaggccgtatgaatgCagtgaatgtgggaaatcatt	14	4	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr19:58371262C>T	uc002qql.2	+	3	1620	c.1482C>T	c.(1480-1482)TGC>TGT	p.C494C	ZNF587_uc002qqb.2_Silent_p.C451C|ZNF587_uc010yhh.1_Silent_p.C451C|ZNF587_uc002qqi.1_Silent_p.C451C|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Silent_p.C493C	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	494	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		CGTATGAATGCAGTGAATGTG	0.413													0	0	0	0.104719	0	42	230										T	58371262	C	T	58371262	2	4	108	1	0	0	0	0	0	0	0	1	18017	718	25	2		2	ZNF587	19	58371262	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1044095	58371262	757721	268	33146										
RBCK1	10616	broad.mit.edu	37	chr20	390664	390664	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gaggtctccccaacgcaggaCatcaggtgaggagtgcatgg	15	10	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:390664C>T	uc002wdp.3	+	2	855	c.162C>T	c.(160-162)GAC>GAT	p.D54D	RBCK1_uc010zpl.1_Silent_p.D54D|RBCK1_uc010zpm.1_RNA|RBCK1_uc002wdq.3_Intron|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Intron|RBCK1_uc002wdo.2_RNA	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	54	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CAACGCAGGACATCAGGTGAG	0.517													0	0	0	0.076483	0	24	41										T	390664	C	T	390664	2	4	108	1	0	0	0	0	0	0	0	1	13107	477	17	2		2	RBCK1	20	390664	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		390664	62634856	269	33147										
BFSP1	631	broad.mit.edu	37	chr20	17492687	17492687	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atgatctgctgcaggatgctGatataggtctgaacttccag	11	8	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:17492687G>C	uc002wpo.2	-	4	600	c.561C>G	c.(559-561)ATC>ATG	p.I187M	BFSP1_uc002wpp.2_Missense_Mutation_p.I62M|BFSP1_uc010zrn.1_Missense_Mutation_p.I48M|BFSP1_uc010zro.1_Missense_Mutation_p.I48M	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	187	Rod.|Linker 12.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						GCAGGATGCTGATATAGGTCT	0.473													0	0	0	0.038395	0	17	62										C	17492687	G	C	17492687	3	2	108	1	0	0	0	0	1	0	0	0	1415	1280	45	1	1456	1	BFSP1	20	17492687	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	17102023	17492687	45532833	270	33148										
TMEM90B	79953	broad.mit.edu	37	chr20	24524190	24524190	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgtcctacgatgtggaggagGaggaggagttccaggagctg	18	6	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:24524190G>A	uc002wtw.1	+	2	1090	c.457G>A	c.(457-459)GAG>AAG	p.E153K		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	153	Poly-Glu.|Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						TGTGGAGGAGGAGGAGGAGTT	0.542													0	0	0	0.139131	0	44	114										A	24524190	G	A	24524190	3	1	108	1	0	0	0	0	1	0	0	0	16216	1175	41	1	459	1	TMEM90B	20	24524190	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	7031503	24524190	38501330	271	33149										
KIAA1755	85449	broad.mit.edu	37	chr20	36870149	36870149	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggcttcttgtccactgtgcaGaggtccagggagaggcattt	14	9	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:36870149G>C	uc002xhy.1	-	3	656	c.384C>G	c.(382-384)CTC>CTG	p.L128L	KIAA1755_uc002xhz.1_Silent_p.L128L	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	128										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				CCACTGTGCAGAGGTCCAGGG	0.537													0	0	0	0.11126	0	42	135										C	36870149	G	C	36870149	2	2	108	1	0	0	0	0	0	0	0	1	8257	929	33	1		1	KIAA1755	20	36870149	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	12345959	36870149	26155371	272	33150										
PPP1R16B	26051	broad.mit.edu	37	chr20	37547022	37547022	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccccgccctggagcagctacAaggaacagagccctcagacg	11	16	1	2	rs61752055	byFrequency	TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:37547022A>C	uc002xje.2	+	11	1606	c.1417A>C	c.(1417-1419)AAG>CAG	p.K473Q	PPP1R16B_uc010ggc.2_Missense_Mutation_p.K431Q	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	473					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding	p.K473Q(1)		upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GAGCAGCTACAAGGAACAGAG	0.642													0	0	0	0.014758	0	5	122										C	37547022	A	C	37547022	3	2	108	1	0	0	0	0	1	0	0	0	12366	131	5	5	1455	5	PPP1R16B	20	37547022	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08	676873	37547022	25478498	273	33151										
MMP9	4318	broad.mit.edu	37	chr20	44639945	44639945	+	Frame_Shift_Del	DEL	C	C	-													0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gacgaccggtttggcttctgCcccagcgagagtgagtgagg							TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44639945delC	uc002xqz.2	+	5	832	c.813delC	c.(811-813)TGCfs	p.C271fs		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	271	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TTGGCTTCTGCCCCAGCGAGA	0.552																		39	82	---	---								-	44639945	C	-	44639945	7	5	108	1	0	1	0	1	0	0	0	0	9669	747	26	0	831	0	MMP9	20	44639945	Frame_Shift_Del	DEL	C	TCGA-GC-A3YS-01A-11D-A23M-08	7092923	44639945	18385575	274	33152										
SLC12A5	57468	broad.mit.edu	37	chr20	44676189	44676189	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atgctcattgctggactcatCtacaagtacattgagtaccg	8	10	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44676189C>G	uc010zxl.1	+	15	2029	c.1953C>G	c.(1951-1953)ATC>ATG	p.I651M	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.I628M	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	651	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGGACTCATCTACAAGTACA	0.318													0	0	0	0.043863	0	18	156										G	44676189	C	G	44676189	3	3	108	1	0	0	0	0	1	0	0	0	14386	903	32	1	2067	1	SLC12A5	20	44676189	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	36244	44676189	18349331	275	33153										
SLC12A5	57468	broad.mit.edu	37	chr20	44676672	44676672	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtctgtctctcagtgcggctCgctatgccctcttacgcctg	10	15	4	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44676672C>G	uc010zxl.1	+	16	2105	c.2029C>G	c.(2029-2031)CGC>GGC	p.R677G	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.R654G	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	677					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CAGTGCGGCTCGCTATGCCCT	0.602													0	0	0	0.009096	0	4	17										G	44676672	C	G	44676672	3	3	108	1	0	0	0	0	1	0	0	0	14386	884	31	1	2147	1	SLC12A5	20	44676672	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	483	44676672	18348848	276	33154										
CDH22	64405	broad.mit.edu	37	chr20	44806753	44806753	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cagtgtgggcggcccactgtCtaccaccaggatgggcagga	15	12	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:44806753C>T	uc002xrm.2	-	10	2148	c.1747G>A	c.(1747-1749)GAC>AAC	p.D583N	CDH22_uc010ghk.1_Missense_Mutation_p.D583N	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	583	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGCCCACTGTCTACCACCAGG	0.632													0	0	0	0.021553	0	6	37										T	44806753	C	T	44806753	3	4	108	1	0	0	0	0	1	0	0	0	3107	913	32	1	747	1	CDH22	20	44806753	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	130081	44806753	18218767	277	33155										
ZNF831	128611	broad.mit.edu	37	chr20	57767194	57767194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cggagcacagcgccgagtccGagggggagggcggcccgggc	21	13	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:57767194G>A	uc002yan.2	+	1	1120	c.1120G>A	c.(1120-1122)GAG>AAG	p.E374K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	374						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CGCCGAGTCCGAGGGGGAggg	0.527													0	0	0	0.02938	0	6	12										A	57767194	G	A	57767194	3	1	108	1	0	0	0	0	1	0	0	0	18182	1059	37	1	1122	1	ZNF831	20	57767194	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	12960441	57767194	5258326	278	33156										
CDH4	1002	broad.mit.edu	37	chr20	60511869	60511869	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	gtcttcgactacgaggggagCggctccaccgcaggctccgt	14	14	1	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:60511869C>T	uc002ybn.1	+	16	2633	c.2619C>T	c.(2617-2619)AGC>AGT	p.S873S	CDH4_uc002ybp.1_Silent_p.S799S|uc002ybr.1_5'Flank	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	873	Ser-rich.|Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACGAGGGGAGCGGCTCCACCG	0.622													0	0	0	0.02938	0	7	48										T	60511869	C	T	60511869	2	4	108	1	0	0	0	0	0	0	0	1	3112	767	27	2		2	CDH4	20	60511869	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	2744675	60511869	2513651	279	33157										
EEF1A2	1917	broad.mit.edu	37	chr20	62121972	62121972	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cagagcttcgctcagagcctCgtggtgcatctccactgact	10	14	2	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr20:62121972C>T	uc002yfd.1	-	5	990	c.889G>A	c.(889-891)GAG>AAG	p.E297K	EEF1A2_uc002yfe.1_Missense_Mutation_p.E297K|EEF1A2_uc010gkg.1_Missense_Mutation_p.E297K	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	297						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			CTCAGAGCCTCGTGGTGCATC	0.627													0	0	0	0.092188	0	38	104										T	62121972	C	T	62121972	3	4	108	1	0	0	0	0	1	0	0	0	4924	893	31	1	514	1	EEF1A2	20	62121972	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	1610103	62121972	903548	280	33158										
GRIK1	2897	broad.mit.edu	37	chr21	31062135	31062135	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cctgctgatagctgcataatCtgggtaaaggttgatgtaaa	11	6	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:31062135C>A	uc002yno.1	-	3	921	c.457G>T	c.(457-459)GAT>TAT	p.D153Y	GRIK1_uc002ynn.2_Missense_Mutation_p.D153Y|GRIK1_uc011acs.1_Missense_Mutation_p.D153Y|GRIK1_uc011act.1_Missense_Mutation_p.D97Y|GRIK1_uc010glq.1_Intron|GRIK1_uc002ynr.2_Missense_Mutation_p.D153Y	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	153	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GCTGCATAATCTGGGTAAAGG	0.473													1	0	3.90494e-43	0.139131	4.35183e-43	90	140										A	31062135	C	A	31062135	3	1	108	1	0	0	0	0	1	0	0	0	6773	913	32	3	2519	3	GRIK1	21	31062135	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		31062135	17067760	281	33159										
RUNX1	861	broad.mit.edu	37	chr21	36206817	36206817	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tgaccctcatggctgtgcgcCgcagctgctccagttcactg	11	15	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:36206817C>A	uc002yuh.2	-	4	2192	c.614G>T	c.(613-615)CGG>CTG	p.R205L	RUNX1_uc002yui.2_Intron|RUNX1_uc010gmu.2_Missense_Mutation_p.R232L|RUNX1_uc010gmv.2_Missense_Mutation_p.R232L|RUNX1_uc002yuj.3_Missense_Mutation_p.R100L|RUNX1_uc002yuk.3_Missense_Mutation_p.R232L|RUNX1_uc002yul.1_5'UTR|RUNX1_uc002yum.1_Intron|RUNX1_uc010gmw.1_Missense_Mutation_p.R232L|RUNX1_uc002yuo.1_Missense_Mutation_p.R205L	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	205	Pro/Ser/Thr-rich.			Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						GGCTGTGCGCCGCAGCTGCTC	0.597			T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				1	0	7.73544e-29	0.139131	8.50483e-29	59	45										A	36206817	C	A	36206817	3	1	108	1	0	0	0	0	1	0	0	0	13746	652	23	4	792	4	RUNX1	21	36206817	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	5144682	36206817	11923078	282	33160										
DSCAM	1826	broad.mit.edu	37	chr21	41465774	41465774	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	aattctgtaggaaaacgagtCgggagaggcctcaaactcgc	12	9	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:41465774C>T	uc002yyq.1	-	21	4176	c.3724G>A	c.(3724-3726)GAC>AAC	p.D1242N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1242	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GAAAACGAGTCGGGAGAGGCC	0.478													0	0	0	0.069288	0	21	41										T	41465774	C	T	41465774	3	4	108	1	0	0	0	0	1	0	0	0	4768	884	31	1	2366	1	DSCAM	21	41465774	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	5258957	41465774	6664121	283	33161										
PCNT	5116	broad.mit.edu	37	chr21	47809235	47809235	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cacatgcgtgaaagctttctCatgagcccagaaagtgtgcg	11	10	1	3			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr21:47809235C>T	uc002zji.3	+	19	3836	c.3729C>T	c.(3727-3729)CTC>CTT	p.L1243L	PCNT_uc002zjj.2_Silent_p.L1125L	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1243					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AAAGCTTTCTCATGAGCCCAG	0.577													0	0	0	0.059317	0	31	83										T	47809235	C	T	47809235	2	4	108	1	0	0	0	0	0	0	0	1	11590	813	29	1		1	PCNT	21	47809235	Silent	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	6343461	47809235	320660	284	33162										
SUSD2	56241	broad.mit.edu	37	chr22	24579560	24579560	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agagcggccgcatccccttcActgtgtcactggacaacggc	11	15	2	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:24579560A>T	uc002zzn.1	+	3	429	c.385A>T	c.(385-387)ACT>TCT	p.T129S		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	129	Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CATCCCCTTCACTGTGTCACT	0.642													0	0	0	0.139131	0	45	30										T	24579560	A	T	24579560	3	4	108	1	0	0	0	0	1	0	0	0	15405	159	6	5	395	5	SUSD2	22	24579560	Missense_Mutation	SNP	A	TCGA-GC-A3YS-01A-11D-A23M-08		24579560	26725006	285	33163										
EMID1	129080	broad.mit.edu	37	chr22	29628275	29628275	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ccccccagggagccctggccGggctggagctgtgggcaccc	16	17	0	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chr22:29628275G>A	uc003aen.2	+	8	776	c.701G>A	c.(700-702)CGG>CAG	p.R234Q	EMID1_uc003aem.2_Missense_Mutation_p.R236Q|EMID1_uc003aeo.2_Missense_Mutation_p.R236Q|EMID1_uc003aep.2_Missense_Mutation_p.R236Q	NM_133455	NP_597712	Q96A84	EMID1_HUMAN	EMI domain containing 1	234	Collagen-like.					collagen					0						AGCCCTGGCCGGGCTGGAGCT	0.701													0	0	0	0.134883	0	31	25										A	29628275	G	A	29628275	3	1	108	1	0	0	0	0	1	0	0	0	5091	1116	39	2	737	2	EMID1	22	29628275	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5048715	29628275	21676291	286	33164										
NYX	60506	broad.mit.edu	37	chrX	41333009	41333009	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	cacaacaacctgtccttcatCacgcccggcgccttcaaggg	8	17	3	0			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:41333009C>G	uc004dfh.2	+	2	733	c.303C>G	c.(301-303)ATC>ATG	p.I101M	NYX_uc011mku.1_Missense_Mutation_p.I96M	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	101	LRR 2.		Missing (in CSNB1A).		response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2						TGTCCTTCATCACGCCCGGCG	0.716													0	0	0	0.115264	0	2	6										G	41333009	C	G	41333009	3	3	108	1	0	0	0	0	1	0	0	0	10797	816	29	1	309	1	NYX	23	41333009	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08		41333009	113937551	287	33165										
CHST7	56548	broad.mit.edu	37	chrX	46433799	46433799	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ggcaggcgctgtatccgggcGacgccgagagcttgcagggc	18	12	0	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:46433799G>A	uc004dgt.2	+	1	608	c.433G>A	c.(433-435)GAC>AAC	p.D145N		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	145	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						GTATCCGGGCGACGCCGAGAG	0.557													0	0	0	0.064281	0	33	16										A	46433799	G	A	46433799	3	1	108	1	0	0	0	0	1	0	0	0	3409	1058	37	1	435	1	CHST7	23	46433799	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	5100790	46433799	108836761	288	33166										
GNL3L	54552	broad.mit.edu	37	chrX	54578731	54578731	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atctcccaatgcagcgggaaGatcagcttctatataccacc	7	13	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:54578731G>C	uc004dth.1	+	13	1327	c.1188G>C	c.(1186-1188)AAG>AAC	p.K396N	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	396					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						GCAGCGGGAAGATCAGCTTCT	0.502													0	0	0	0.038395	0	18	55										C	54578731	G	C	54578731	3	2	108	1	0	0	0	0	1	0	0	0	6538	933	33	1	1234	1	GNL3L	23	54578731	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	8144932	54578731	100691829	289	33167										
UPRT	139596	broad.mit.edu	37	chrX	74494400	74494400	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	agaggactgcgaactctcccGgcagatcggggcgcagctta	14	12	1	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:74494400G>A	uc004ecb.1	+	1	440	c.311G>A	c.(310-312)CGG>CAG	p.R104Q	UPRT_uc010nlu.1_Missense_Mutation_p.R104Q|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Missense_Mutation_p.R104Q|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	104					nucleoside metabolic process	cytoplasm|nucleus					0						GAACTCTCCCGGCAGATCGGG	0.562													0	0	0	0.009096	0	4	7										A	74494400	G	A	74494400	3	1	108	1	0	0	0	0	1	0	0	0	17011	1116	39	2	313	2	UPRT	23	74494400	Missense_Mutation	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	19915669	74494400	80776160	290	33168										
C1GALT1C1	29071	broad.mit.edu	37	chrX	119760538	119760538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	atagaaaggctgtgatggatCcttttttaacaaaaaatact	7	5	0	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:119760538C>T	uc004esy.2	-	3	831	c.484G>A	c.(484-486)GAT>AAT	p.D162N	C1GALT1C1_uc004esz.2_Missense_Mutation_p.D162N	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	162	Lumenal (Potential).					integral to membrane					0						TGTGATGGATCCTTTTTTAAC	0.383													0	0	0	0.116897	0	27	46										T	119760538	C	T	119760538	3	4	108	1	0	0	0	0	1	0	0	0	1953	855	30	1	476	1	C1GALT1C1	23	119760538	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	45266138	119760538	35510022	291	33169										
MAGEC2	51438	broad.mit.edu	37	chrX	141291225	141291225	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	tccatgaactcacgggctctCttgagtatcacaggaaagta	9	10	3	2			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:141291225C>G	uc004fbu.1	-	3	897	c.549G>C	c.(547-549)AAG>AAC	p.K183N		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	183	MAGE.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CACGGGCTCTCTTGAGTATCA	0.483										HNSCC(46;0.14)			0	0	0	0.139131	0	112	73										G	141291225	C	G	141291225	3	3	108	1	0	0	0	0	1	0	0	0	9181	912	32	1	576	1	MAGEC2	23	141291225	Missense_Mutation	SNP	C	TCGA-GC-A3YS-01A-11D-A23M-08	21530687	141291225	13979335	292	33170										
TMLHE	55217	broad.mit.edu	37	chrX	154736681	154736681	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.398625429553265	116	5.31526310004557e-36	3.534559122308	5.4883318320009	2.4314085447263	0.096637324891665	0.217754357439058	83	ttcaatggcactttactgagGagttcaaattcctcaggtgc	9	9	3	1			TCGA-GC-A3YS-01A-11D-A23M-08	TCGA-GC-A3YS-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a310d405-19f3-4dfb-be83-c4e2d949c067	0c579d4b-726a-4969-acb5-e0f3b977778e	g.chrX:154736681G>A	uc004fnn.2	-	6	1039	c.873C>T	c.(871-873)CTC>CTT	p.L291L	TMLHE_uc004fno.2_Silent_p.L291L|TMLHE_uc004fnp.3_Silent_p.L291L	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	291					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	CTTTACTGAGGAGTTCAAATT	0.418													0	0	0	0.139131	0	90	48										A	154736681	G	A	154736681	2	1	108	1	0	0	0	0	0	0	0	1	16229	1161	41	1		1	TMLHE	23	154736681	Silent	SNP	G	TCGA-GC-A3YS-01A-11D-A23M-08	13445456	154736681	533879	293	33171										
SCNN1D	6339	broad.mit.edu	37	chr1	1221398	1221398	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaggggctggtggagctgccCgcctcgttccgggagctgct	18	12	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:1221398C>T	uc001adu.1	+	6	783	c.159C>T	c.(157-159)CCC>CCT	p.P53P	SCNN1D_uc001adt.1_Silent_p.P217P|SCNN1D_uc001adw.2_Silent_p.P119P|SCNN1D_uc001adx.2_5'UTR|SCNN1D_uc001adv.2_Silent_p.P53P	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		TGGAGCTGCCCGCCTCGTTCC	0.612													0	0	0	0.009096	0	3	6										T	1221398	C	T	1221398	2	4	109	1	0	0	0	0	0	0	0	1	13929	639	23	2		2	SCNN1D	1	1221398	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		1221398	248029223	1	33172										
CASZ1	54897	broad.mit.edu	37	chr1	10715772	10715772	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggtagtagacgctgcagtcGtccagcgggctgaaacgcat	14	10	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:10715772G>A	uc001aro.2	-	9	1919	c.1599C>T	c.(1597-1599)GAC>GAT	p.D533D	CASZ1_uc001arp.1_Silent_p.D533D|CASZ1_uc009vmx.2_Silent_p.D557D	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CGCTGCAGTCGTCCAGCGGGC	0.612													0	0	0	0.058154	0	10	47										A	10715772	G	A	10715772	2	1	109	1	0	0	0	0	0	0	0	1	2685	1136	40	2		2	CASZ1	1	10715772	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	9494374	10715772	238534849	2	33173										
MAD2L2	10459	broad.mit.edu	37	chr1	11740482	11740482	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acctcgcgcacgtagaggatGagatgcacagccacctccag	11	14	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:11740482G>A	uc001asp.2	-	3	275	c.87C>T	c.(85-87)CTC>CTT	p.L29L	MAD2L2_uc009vnc.2_Silent_p.L29L|MAD2L2_uc001asq.3_Silent_p.L29L	NM_006341	NP_006332	Q9UI95	MD2L2_HUMAN	MAD2 homolog	29	Mediates interaction with REV1 and REV3L and homodimerization.|HORMA.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding				0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CGTAGAGGATGAGATGCACAG	0.572								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.139131	0	50	144										A	11740482	G	A	11740482	2	1	109	1	0	0	0	0	0	0	0	1	9150	1277	45	1		1	MAD2L2	1	11740482	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1024710	11740482	237510139	3	33174										
KDM1A	23028	broad.mit.edu	37	chr1	23408824	23408824	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atgatttaatggctcagccaAtcactcctggcccctcgatt	7	13	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:23408824A>G	uc001bgi.2	+	18	2487	c.2338A>G	c.(2338-2340)ATC>GTC	p.I780V	KDM1A_uc001bgj.2_Missense_Mutation_p.I804V	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	780	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						GGCTCAGCCAATCACTCCTGG	0.527													0	0	0	0.049695	0	19	51										G	23408824	A	G	23408824	3	3	109	1	0	0	0	0	1	0	0	0	8122	101	4	5	2488	5	KDM1A	1	23408824	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	11668342	23408824	225841797	4	33175										
MYOM3	127294	broad.mit.edu	37	chr1	24419481	24419481	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gttcccggggtccgaagggcGagggcacccggaccatgtag	17	12	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:24419481G>A	uc001bin.3	-	10	1209	c.1046C>T	c.(1045-1047)TCG>TTG	p.S349L	MYOM3_uc001bim.3_Missense_Mutation_p.S6L|MYOM3_uc001bio.2_Missense_Mutation_p.S349L|MYOM3_uc001bip.1_Missense_Mutation_p.S6L	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	349	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TCCGAAGGGCGAGGGCACCCG	0.458													0	0	0	0.047766	0	9	28										A	24419481	G	A	24419481	3	1	109	1	0	0	0	0	1	0	0	0	10093	1059	37	1	3379	1	MYOM3	1	24419481	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1010657	24419481	224831140	5	33176										
ARID1A	8289	broad.mit.edu	37	chr1	27097694	27097694	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgccagctccttgaaaaagCagtatatccagtgtctctat	7	11	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:27097694C>T	uc001bmv.1	+	12	3656	c.3283C>T	c.(3283-3285)CAG>TAG	p.Q1095*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1095*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1095*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q712*|ARID1A_uc001bmx.1_5'UTR|ARID1A_uc009vsm.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1095	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTGAAAAAGCAGTATATCCA	0.483			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.105934	0	13	74										T	27097694	C	T	27097694	4	4	109	1	0	0	0	0	0	1	0	0	913	711	25	2	3329	2	ARID1A	1	27097694	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2678213	27097694	222152927	6	33177										
KIAA0319L	79932	broad.mit.edu	37	chr1	35917362	35917362	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgttagcattctcgagctgCaccccatcaggtcccctgca	8	16	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:35917362C>T	uc001byx.2	-	13	2187	c.1929G>A	c.(1927-1929)GTG>GTA	p.V643V	KIAA0319L_uc001byw.2_Silent_p.V85V|KIAA0319L_uc010ohv.1_Silent_p.V285V	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	643	PKD 4.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCTCGAGCTGCACCCCATCAG	0.507											OREG0013354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	71	111										T	35917362	C	T	35917362	2	4	109	1	0	0	0	0	0	0	0	1	8169	697	25	2		2	KIAA0319L	1	35917362	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	8819668	35917362	213333259	7	33178										
KIAA0754	643314	broad.mit.edu	37	chr1	39879235	39879235	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccccagctgctgcagtgcccAccccagaggagcccacctcc	9	21	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:39879235A>C	uc009vvt.1	+	1	4060	c.3298A>C	c.(3298-3300)ACC>CCC	p.T1100P	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	964	7.|Ala-rich.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGCAGTGCCCACCCCAGAGGA	0.731													0	0	0	0.02938	0	4	80										C	39879235	A	C	39879235	3	2	109	1	0	0	0	0	1	0	0	0	8192	159	6	5	3300	5	KIAA0754	1	39879235	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	3961873	39879235	209371386	8	33179										
ACOT11	26027	broad.mit.edu	37	chr1	55072835	55072835	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agctagtgcagcaggtagacGaggacgacgccatctaccac	12	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:55072835G>A	uc001cxm.1	+	14	1481	c.1399G>A	c.(1399-1401)GAG>AAG	p.E467K	ACOT11_uc001cxj.1_Missense_Mutation_p.E345K|ACOT11_uc001cxl.1_Missense_Mutation_p.E467K	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	467	START.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						GCAGGTAGACGAGGACGACGC	0.647													0	0	0	0.047766	0	9	28										A	55072835	G	A	55072835	3	1	109	1	0	0	0	0	1	0	0	0	149	1059	37	1	1453	1	ACOT11	1	55072835	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	15193600	55072835	194177786	9	33180										
WLS	79971	broad.mit.edu	37	chr1	68697918	68697918	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggcgatgatttggaacacgAgcagaatcccaccaacaatg	10	10	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:68697918A>T	uc001def.1	-	1	336	c.65T>A	c.(64-66)CTC>CAC	p.L22H	WLS_uc001dee.2_Missense_Mutation_p.L22H|WLS_uc001deg.1_Missense_Mutation_p.L22H|WLS_uc001deh.1_Missense_Mutation_p.L22H	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	22					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						TTGGAACACGAGCAGAATCCC	0.488													0	0	0	0.049695	0	15	72										T	68697918	A	T	68697918	3	4	109	1	0	0	0	0	1	0	0	0	17373	304	11	5	1734	5	WLS	1	68697918	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	13625083	68697918	180552703	10	33181										
TMEM167B	56900	broad.mit.edu	37	chr1	109635586	109635586	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cctacttcaagaaagtacctCgtctcaaaacctggctgcta	6	13	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:109635586C>T	uc001dwn.2	+	2	177	c.85C>T	c.(85-87)CGT>TGT	p.R29C	TMEM167B_uc009weu.2_Intron	NM_020141	NP_064526	Q9NRX6	KISHB_HUMAN	transmembrane protein 167B precursor	29	Extracellular (Potential).					Golgi membrane|integral to membrane					0						GAAAGTACCTCGTCTCAAAAC	0.453													0	0	0	0.139131	0	90	297										T	109635586	C	T	109635586	3	4	109	1	0	0	0	0	1	0	0	0	16079	884	31	1	91	1	TMEM167B	1	109635586	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	40937668	109635586	139615035	11	33182										
GPR61	83873	broad.mit.edu	37	chr1	110086286	110086287	+	Missense_Mutation	DNP	CC	CC	TA													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttgtggtggtctttgctgtCctttactttctgttgcccct							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086286_110086287CC>TA	uc001dxy.2	+	2	1325_1326	c.642_643CC>TA	c.(640-645)GTCCTT>GTTATT	p.L215I		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	215	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TCTTTGCTGTCCTTTACTTTCT	0.609													0	0	0	0.115264	0	25	902										TA	110086287	CC	TA	110086286	3	4	109	1	0	0	0	0	1	0	0	0	6702	842	30	1	644	1	GPR61	1	110086286	Missense_Mutation	DNP	CC	TCGA-GD-A2C5-01A-12D-A17V-08	450700	110086286	139164335	12	33183			1	149		7	6	439	N	CC_C	1.999424e-14
GPR61	83873	broad.mit.edu	37	chr1	110086421	110086421	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cggcaacgctccgaatctctCagcagccgctccacgatggt	10	16	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086421C>G	uc001dxy.2	+	2	1460	c.777C>G	c.(775-777)CTC>CTG	p.L259L		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	259	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCGAATCTCTCAGCAGCCGCT	0.672													0	0	0	0.083992	0	24	673										G	110086421	C	G	110086421	2	3	109	1	0	0	0	0	0	0	0	1	6702	813	29	1		1	GPR61	1	110086421	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	135	110086421	139164200	13	33184			1	149		7	6	439	N	CC_C	1.999424e-14
GPR61	83873	broad.mit.edu	37	chr1	110086532	110086532	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctggctgtggggggacagttCctgctctgttggttgcccta	15	10	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086532C>T	uc001dxy.2	+	2	1571	c.888C>T	c.(886-888)TTC>TTT	p.F296F		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	296	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGGGACAGTTCCTGCTCTGTT	0.607													0	0	0	0.076483	0	24	536										T	110086532	C	T	110086532	2	4	109	1	0	0	0	0	0	0	0	1	6702	854	30	1		1	GPR61	1	110086532	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	111	110086532	139164089	14	33185			1	149		7	6	439	N	CC_C	1.999424e-14
GPR61	83873	broad.mit.edu	37	chr1	110086556	110086556	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctctgttggttgccctacttCtctttccacctctatgttgc	6	14	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086556C>G	uc001dxy.2	+	2	1595	c.912C>G	c.(910-912)TTC>TTG	p.F304L		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	304	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGCCCTACTTCTCTTTCCACC	0.577													0	0	0	0.069288	0	22	705										G	110086556	C	G	110086556	3	3	109	1	0	0	0	0	1	0	0	0	6702	912	32	1	914	1	GPR61	1	110086556	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	24	110086556	139164065	15	33186			1	149		7	6	439	N	CC_C	1.999424e-14
GPR61	83873	broad.mit.edu	37	chr1	110086651	110086651	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggctacttttgcttcacttCcaaccctttcttctatggat	5	12	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086651C>G	uc001dxy.2	+	2	1690	c.1007C>G	c.(1006-1008)TCC>TGC	p.S336C		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	336	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGCTTCACTTCCAACCCTTTC	0.532													0	0	0	0.125774	0	25	742										G	110086651	C	G	110086651	3	3	109	1	0	0	0	0	1	0	0	0	6702	855	30	1	1009	1	GPR61	1	110086651	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	95	110086651	139163970	16	33187			1	149		7	6	439	N	CC_C	1.999424e-14
GPR61	83873	broad.mit.edu	37	chr1	110086715	110086715	+	Silent	SNP	C	C	G													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gagctcagcaagcagtttgtCtgcttcttcaagccagctcc							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086715C>G	uc001dxy.2	+	2	1754	c.1071C>G	c.(1069-1071)GTC>GTG	p.V357V		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	357	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		AGCAGTTTGTCTGCTTCTTCA	0.562													0	0	0	0.0333	0	16	498										G	110086715	C	G	110086715	2	3	109	1	0	0	0	0	0	0	0	1	6702	900	32	1		1	GPR61	1	110086715	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	64	110086715	139163906	17	33188	166	2	1	149		7	6	439	N	CC_C	1.999424e-14
GPR61	83873	broad.mit.edu	37	chr1	110086724	110086724	+	Silent	SNP	C	C	T													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aagcagtttgtctgcttcttCaagccagctccagaggagga							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110086724C>T	uc001dxy.2	+	2	1763	c.1080C>T	c.(1078-1080)TTC>TTT	p.F360F		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	360	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TCTGCTTCTTCAAGCCAGCTC	0.557													0	0	0	0.146539	0	14	466										T	110086724	C	T	110086724	2	4	109	1	0	0	0	0	0	0	0	1	6702	825	29	1		1	GPR61	1	110086724	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	9	110086724	139163897	18	33189	166	2	1	149		7	6	439	N	CC_C	1.999424e-14
GSTM5	2949	broad.mit.edu	37	chr1	110255280	110255280	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gctcctggaatacacagactCaagctatgtggaaaagaagt	10	8	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:110255280C>G	uc001dyn.2	+	2	148	c.77C>G	c.(76-78)TCA>TGA	p.S26*	GSTM5_uc010ovu.1_5'UTR	NM_000851	NP_000842	P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	26	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			central_nervous_system(6)	6		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TACACAGACTCAAGCTATGTG	0.607													0	0	0	0.049695	0	20	690										G	110255280	C	G	110255280	4	3	109	1	0	0	0	0	0	1	0	0	6841	838	29	1	83	1	GSTM5	1	110255280	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	168556	110255280	138995341	19	33190										
KCNA10	3744	broad.mit.edu	37	chr1	111061247	111061247	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cgtctcatggttggtgctttCgctgatgaggatcttcccgt	12	10	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:111061247C>T	uc001dzt.1	-	1	551	c.163G>A	c.(163-165)GAA>AAA	p.E55K		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	55						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TTGGTGCTTTCGCTGATGAGG	0.582													0	0	0	0.11911	0	14	79										T	111061247	C	T	111061247	3	4	109	1	0	0	0	0	1	0	0	0	8002	893	31	1	1376	1	KCNA10	1	111061247	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	805967	111061247	138189374	20	33191										
ANKRD35	148741	broad.mit.edu	37	chr1	145561860	145561860	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cggggggctttgtcaagaccGgtcatggagggagccctggg	19	9	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:145561860G>A	uc001eob.1	+	10	1656	c.1548G>A	c.(1546-1548)CCG>CCA	p.P516P	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Silent_p.P359P	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	516										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGTCAAGACCGGTCATGGAGG	0.627													0	0	0	0.139131	0	57	201										A	145561860	G	A	145561860	2	1	109	1	0	0	0	0	0	0	0	1	664	1103	39	2		2	ANKRD35	1	145561860	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	34500613	145561860	103688761	21	33192										
ECM1	1893	broad.mit.edu	37	chr1	150482400	150482400	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acattcccccttctatagtgCagccccctccctctcaggag	6	18	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:150482400C>T	uc001eus.2	+	4	425	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	ECM1_uc010pce.1_Intron|ECM1_uc010pcf.1_Intron|ECM1_uc001eut.2_Nonsense_Mutation_p.Q76*|ECM1_uc001euu.2_Nonsense_Mutation_p.Q105*|ECM1_uc001euv.2_Nonsense_Mutation_p.Q103*|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	76					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TTCTATAGTGCAGCCCCCTCC	0.617													0	0	0	0.080935	0	12	75										T	150482400	C	T	150482400	4	4	109	1	0	0	0	0	0	1	0	0	4897	711	25	2	240	2	ECM1	1	150482400	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4920540	150482400	98768221	22	33193										
CHRNB2	1141	broad.mit.edu	37	chr1	154544295	154544295	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccaccacgcacaccatggcGccctgggtgaaggtcgtctt	11	16	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:154544295G>A	uc001ffg.2	+	5	1260	c.996G>A	c.(994-996)GCG>GCA	p.A332A		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	332	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	ACACCATGGCGCCCTGGGTGA	0.642													0	0	0	0.014758	0	5	34										A	154544295	G	A	154544295	2	1	109	1	0	0	0	0	0	0	0	1	3391	1074	38	2		2	CHRNB2	1	154544295	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	4061895	154544295	94706326	23	33194										
SH2D2A	9047	broad.mit.edu	37	chr1	156784028	156784028	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cacgaaggtcaccgcgctctCgctgaaccgcaccaagtagc	10	16	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:156784028C>T	uc001fqd.2	-	4	507	c.367G>A	c.(367-369)GAG>AAG	p.E123K	SH2D2A_uc001fqc.1_Missense_Mutation_p.E95K|SH2D2A_uc009wsh.2_Missense_Mutation_p.E133K|SH2D2A_uc001fqe.2_Missense_Mutation_p.E105K|SH2D2A_uc010phs.1_Missense_Mutation_p.E123K|NTRK1_uc001fqf.1_5'Flank|NTRK1_uc009wsi.1_5'Flank	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	123	SH2.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACCGCGCTCTCGCTGAACCGC	0.692													0	0	0	0.047766	0	7	40										T	156784028	C	T	156784028	3	4	109	1	0	0	0	0	1	0	0	0	14232	893	31	1	822	1	SH2D2A	1	156784028	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2239733	156784028	92466593	24	33195										
CD1C	911	broad.mit.edu	37	chr1	158261130	158261130	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acctagagttgttatttcgtTtctacctctttggattaact	6	8	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:158261130T>A	uc001fru.2	+	2	560	c.268T>A	c.(268-270)TTC>ATC	p.F90I	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	90	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					GTTATTTCGTTTCTACCTCTT	0.398													0	0	0	0.055883	0	21	110										A	158261130	T	A	158261130	3	1	109	1	0	0	0	0	1	0	0	0	2976	1841	64	5	274	5	CD1C	1	158261130	Missense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	1477102	158261130	90989491	25	33196										
SPTA1	6708	broad.mit.edu	37	chr1	158589083	158589083	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgacacatctcaaagttcttGacctgtcttgcctcttcctt	5	13	4	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:158589083G>C	uc001fst.1	-	45	6658	c.6459C>G	c.(6457-6459)GTC>GTG	p.V2153V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2153					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAAAGTTCTTGACCTGTCTTG	0.473													0	0	0	0.02938	0	7	239										C	158589083	G	C	158589083	2	2	109	1	0	0	0	0	0	0	0	1	15115	1277	45	1		1	SPTA1	1	158589083	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	327953	158589083	90661538	26	33197										
OR6K6	128371	broad.mit.edu	37	chr1	158725151	158725151	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcctgcttttgtggcttcctCcttgtgcttcctgagattgc	9	12	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:158725151C>T	uc001fsw.1	+	1	546	c.546C>T	c.(544-546)CTC>CTT	p.L182L		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	182	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					GTGGCTTCCTCCTTGTGCTTC	0.478													0	0	0	0.0918	0	26	144										T	158725151	C	T	158725151	2	4	109	1	0	0	0	0	0	0	0	1	11204	842	30	1		1	OR6K6	1	158725151	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	136068	158725151	90525470	27	33198										
FASLG	356	broad.mit.edu	37	chr1	172628518	172628518	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccactaccacctccgccgccGccgccaccactgcctccact	5	25	0	0	rs143516344	byFrequency	TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:172628518G>A	uc001gis.2	+	1	334	c.177G>A	c.(175-177)CCG>CCA	p.P59P	FASLG_uc001git.2_Silent_p.P59P	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	59	Pro-rich.|Poly-Pro.|Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						ctccgccgccgccgccaccac	0.333													0	0	0	0.099896	0	25	13										A	172628518	G	A	172628518	2	1	109	1	0	0	0	0	0	0	0	1	5682	1074	38	2		2	FASLG	1	172628518	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	13903367	172628518	76622103	28	33199										
ELF3	1999	broad.mit.edu	37	chr1	201981484	201981494	+	Frame_Shift_Del	DEL	CTGATGAGCTC	CTGATGAGCTC	-													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttgtcagcttccagctcttCtgatgagctcagttggatca							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			CTGATGAGCTC	-	CTGATGAGCTC	CTGATGAGCTC		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:201981484_201981494delCTGATGAGCTC	uc001gxg.3	+	3	3590_3600	c.398_408delCTGATGAGCTC	c.(397-408)TCTGATGAGCTCfs	p.S133fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.S133fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.S133fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	133_136					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						TCCAGCTCTTCTGATGAGCTCAGTTGGATCA	0.583																		66	66	---	---								-	201981494	CTGATGAGCTC	-	201981484	7	5	109	1	0	1	0	1	0	0	0	0	5055	913	32	0	408	0	ELF3	1	201981484	Frame_Shift_Del	DEL	CTGATGAGCTC	TCGA-GD-A2C5-01A-12D-A17V-08	29352966	201981484	47269137	29	33200			2	150	91894760	3	3	922	N	G_CTGATGAGCTC_C	4.987358e-05
ELF3	1999	broad.mit.edu	37	chr1	201982087	201982087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccccccagggactggtgcttCtcggagctcccactcctcag	10	18	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:201982087C>G	uc001gxg.3	+	5	3803	c.611C>G	c.(610-612)TCT>TGT	p.S204C	ELF3_uc001gxi.3_Missense_Mutation_p.S204C|ELF3_uc001gxh.3_Missense_Mutation_p.S204C	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	204					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						ACTGGTGCTTCTCGGAGCTCC	0.647													0	0	0	0.069234	0	11	40										G	201982087	C	G	201982087	3	3	109	1	0	0	0	0	1	0	0	0	5055	913	32	1	629	1	ELF3	1	201982087	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	603	201982087	47268534	30	33201			2	150	91894760	3	3	922	N	G_CTGATGAGCTC_C	4.987358e-05
ELF3	1999	broad.mit.edu	37	chr1	201982405	201982405	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aagagtactgggactgtctcGagggcaagaagagcaagcac	14	8	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:201982405G>C	uc001gxg.3	+	6	3976	c.784G>C	c.(784-786)GAG>CAG	p.E262Q	ELF3_uc001gxi.3_Missense_Mutation_p.E262Q|ELF3_uc001gxh.3_Missense_Mutation_p.E262Q	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	262					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GGACTGTCTCGAGGGCAAGAA	0.632													0	0	0	0.083992	0	25	85										C	201982405	G	C	201982405	3	2	109	1	0	0	0	0	1	0	0	0	5055	1059	37	1	806	1	ELF3	1	201982405	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	318	201982405	47268216	31	33202			2	150	91894760	3	3	922	N	G_CTGATGAGCTC_C	4.987358e-05
KLHL12	59349	broad.mit.edu	37	chr1	202880190	202880190	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgcactacttacctcagcatCtattacatctgtgatatacc	4	12	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:202880190C>G	uc001gyo.1	-	5	909	c.709G>C	c.(709-711)GAT>CAT	p.D237H	KLHL12_uc001gym.1_5'Flank|KLHL12_uc001gyn.1_Missense_Mutation_p.D87H|KLHL12_uc010pqc.1_Missense_Mutation_p.D275H|KLHL12_uc009xah.1_Missense_Mutation_p.D237H	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	237					Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			ACCTCAGCATCTATTACATCT	0.438													0	0	0	0.139131	0	86	122										G	202880190	C	G	202880190	3	3	109	1	0	0	0	0	1	0	0	0	8368	913	32	1	1029	1	KLHL12	1	202880190	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	897785	202880190	46370431	32	33203										
KLHL12	59349	broad.mit.edu	37	chr1	202880307	202880307	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cacccagttgatgacagcctCaaagactggctcttcagaat	8	12	3	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:202880307C>G	uc001gyo.1	-	5	792	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	KLHL12_uc001gym.1_5'Flank|KLHL12_uc001gyn.1_Missense_Mutation_p.E48Q|KLHL12_uc010pqc.1_Missense_Mutation_p.E236Q|KLHL12_uc009xah.1_Missense_Mutation_p.E198Q	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12	198				FE -> LG (in Ref. 3; BAD96792).	Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			ATGACAGCCTCAAAGACTGGC	0.473													0	0	0	0.139131	0	87	132										G	202880307	C	G	202880307	3	3	109	1	0	0	0	0	1	0	0	0	8368	835	29	1	1146	1	KLHL12	1	202880307	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	117	202880307	46370314	33	33204										
PIK3C2B	5287	broad.mit.edu	37	chr1	204401357	204401357	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gttggggtggaagatcttctCatggcggcagaggaaaacat	15	6	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:204401357C>A	uc001haw.2	-	28	4605	c.4126G>T	c.(4126-4128)GAG>TAG	p.E1376*	PIK3C2B_uc010pqv.1_Nonsense_Mutation_p.E1348*	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1376	PX.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			AAGATCTTCTCATGGCGGCAG	0.537											OREG0014134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.46703e-50	0.139131	4.17363e-50	103	124										A	204401357	C	A	204401357	4	1	109	1	0	0	0	0	0	1	0	0	11910	835	29	3	806	3	PIK3C2B	1	204401357	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1521050	204401357	44849264	34	33205										
NFASC	23114	broad.mit.edu	37	chr1	204956661	204956661	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	attggatacactctcaaataTgtggcctgtacgttctgccc	8	11	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:204956661T>C	uc001hbj.2	+	22	2914	c.2586T>C	c.(2584-2586)TAT>TAC	p.Y862Y	NFASC_uc010pra.1_Silent_p.Y965Y|NFASC_uc001hbi.2_Silent_p.Y965Y|NFASC_uc010prb.1_Silent_p.Y980Y|NFASC_uc010prc.1_Silent_p.Y536Y|NFASC_uc001hbk.1_Silent_p.Y775Y|NFASC_uc001hbl.1_Silent_p.Y112Y|NFASC_uc001hbm.1_Silent_p.Y8Y|NFASC_uc001hbn.1_Silent_p.Y8Y	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	865	Extracellular (Potential).|Fibronectin type-III 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CTCTCAAATATGTGGCCTGTA	0.488													0	0	0	0.069288	0	19	138										C	204956661	T	C	204956661	2	2	109	1	0	0	0	0	0	0	0	1	10359	1471	51	5		5	NFASC	1	204956661	Silent	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	555304	204956661	44293960	35	33206										
DISP1	84976	broad.mit.edu	37	chr1	223175804	223175804	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgccccagctggacactgggAaactacatcgccattctgaa	9	13	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:223175804A>G	uc001hnu.1	+	8	1212	c.1065A>G	c.(1063-1065)GGA>GGG	p.G355G		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	355					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		GGACACTGGGAAACTACATCG	0.502											OREG0014268|OREG0026708	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.038147	0	7	174										G	223175804	A	G	223175804	2	3	109	1	0	0	0	0	0	0	0	1	4539	233	9	5		5	DISP1	1	223175804	Silent	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	18219143	223175804	26074817	36	33207										
SRP9	6726	broad.mit.edu	37	chr1	225977051	225977051	+	Frame_Shift_Del	DEL	A	A	-													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agcccgcaatgttaccatggAaactgagtgaatggtttgaa							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr1:225977051delA	uc001hpg.2	+	3	379	c.251delA	c.(250-252)GAAfs	p.E84fs	SRP9_uc001hpf.3_RNA|SRP9_uc001hph.2_3'UTR|SRP9_uc001hpi.3_RNA	NM_003133	NP_003124	P49458	SRP09_HUMAN	signal recognition particle 9kDa isoform 2	84					negative regulation of translational elongation|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle receptor complex|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding				0						GTTACCATGGAAACTGAGTGA	0.363																		16	15	---	---								-	225977051	A	-	225977051	7	5	109	1	0	1	0	1	0	0	0	0	15157	246	9	0	373	0	SRP9	1	225977051	Frame_Shift_Del	DEL	A	TCGA-GD-A2C5-01A-12D-A17V-08	2801247	225977051	23273570	37	33208										
SNTG2	54221	broad.mit.edu	37	chr2	1079260	1079260	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tccgaaaatgcctatgacatCcggctgaagctgacgaaaga	10	10	0	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:1079260C>G	uc002qwq.2	+	2	257	c.129C>G	c.(127-129)ATC>ATG	p.I43M	SNTG2_uc002qwp.2_RNA|SNTG2_uc010ewi.2_Missense_Mutation_p.I43M	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	43					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CCTATGACATCCGGCTGAAGC	0.473													0	0	0	0.069288	0	21	97										G	1079260	C	G	1079260	3	3	109	1	0	0	0	0	1	0	0	0	14875	845	30	1	135	1	SNTG2	2	1079260	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		1079260	242120113	38	33209										
APOB	338	broad.mit.edu	37	chr2	21225673	21225673	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tccctagtgtatatcccaggTttccccggaaactggaatct	8	12	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:21225673T>C	uc002red.2	-	29	12749	c.12621A>G	c.(12619-12621)AAA>AAG	p.K4207K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4207					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATATCCCAGGTTTCCCCGGAA	0.433													0	0	0	0.09319	0	12	65										C	21225673	T	C	21225673	2	2	109	1	0	0	0	0	0	0	0	1	785	1722	60	5		5	APOB	2	21225673	Silent	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	20146413	21225673	221973700	39	33210										
ASXL2	55252	broad.mit.edu	37	chr2	25982476	25982476	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cagaatggagtccggtgtctCaacgtcaatgtcagcacatt	10	10	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:25982476C>G	uc002rgs.2	-	8	1035	c.814G>C	c.(814-816)GAG>CAG	p.E272Q	ASXL2_uc002rgt.1_Missense_Mutation_p.E12Q	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCGGTGTCTCAACGTCAATG	0.423													0	0	0	0.139131	0	64	104										G	25982476	C	G	25982476	3	3	109	1	0	0	0	0	1	0	0	0	1067	835	29	1	3513	1	ASXL2	2	25982476	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4756803	25982476	217216897	40	33211										
SLC4A1AP	22950	broad.mit.edu	37	chr2	27888132	27888132	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agataaatgctggtagccaaGatgatgagatgggttgcacc	13	6	0	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:27888132G>T	uc002rlk.3	+	2	1273	c.991G>T	c.(991-993)GAT>TAT	p.D331Y	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	331						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					TGGTAGCCAAGATGATGAGAT	0.398													1	0	5.35356e-11	0.076483	6.29079e-11	21	106										T	27888132	G	T	27888132	3	4	109	1	0	0	0	0	1	0	0	0	14653	942	33	3	997	3	SLC4A1AP	2	27888132	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1905656	27888132	215311241	41	33212										
WDR43	23160	broad.mit.edu	37	chr2	29117734	29117735	+	In_Frame_Ins	INS	-	-	CCT													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gagtacgtgccttccgcgcaINScctcagtggtacctgcacct							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:29117734_29117735insCCT	uc002rmo.2	+	1	202_203	c.170_171insCCT	c.(169-171)CAC>CACCTC	p.58_59insL		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	58_59	WD 2.					nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					CCTTCCGCGCACCTCAGTGGTA	0.678																		8	12	---	---								CCT	29117735	-	CCT	29117734	7	5	109	1	0	1	1	0	0	0	0	0	17292	159	6	0	172	0	WDR43	2	29117734	In_Frame_Ins	INS	-	TCGA-GD-A2C5-01A-12D-A17V-08	1229602	29117734	214081639	42	33213										
PRKD3	23683	broad.mit.edu	37	chr2	37487476	37487476	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cattactacaaagactcgttCtggggtttcaaacatacatt	6	9	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:37487476C>T	uc002rqd.2	-	14	2491	c.1936G>A	c.(1936-1938)GAA>AAA	p.E646K	PRKD3_uc002rqe.1_Missense_Mutation_p.E246K	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	646	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AAGACTCGTTCTGGGGTTTCA	0.393													0	0	0	0.09319	0	12	46										T	37487476	C	T	37487476	3	4	109	1	0	0	0	0	1	0	0	0	12520	922	32	1	756	1	PRKD3	2	37487476	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	8369742	37487476	205711897	43	33214										
PRKD3	23683	broad.mit.edu	37	chr2	37487528	37487528	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atcccaggatggtgcaaattCtgaagagaggttgcaagata	12	6	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:37487528C>G	uc002rqd.2	-	14	2440	c.1885_splice	c.e14-1	p.N629_splice	PRKD3_uc002rqe.1_Splice_Site_p.N229_splice	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GGTGCAAATTCTGAAGAGAGG	0.388													0	0	0	0.038147	0	7	37										G	37487528	C	G	37487528	5	3	109	1	0	0	0	0	0	0	1	0	12520	927	32	1	808	1	PRKD3	2	37487528	Splice_Site	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	52	37487528	205711845	44	33215										
PSME4	23198	broad.mit.edu	37	chr2	54167130	54167130	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gagtgttttgagaatattttCtacagaactggggggggaaa	14	3	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:54167130C>T	uc002rxp.2	-	4	564	c.508G>A	c.(508-510)GAA>AAA	p.E170K	PSME4_uc010yop.1_Missense_Mutation_p.E56K|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	170					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGAATATTTTCTACAGAACTG	0.343													0	0	0	0.139131	0	56	57										T	54167130	C	T	54167130	3	4	109	1	0	0	0	0	1	0	0	0	12709	922	32	1	5195	1	PSME4	2	54167130	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	16679602	54167130	189032243	45	33216										
SPTBN1	6711	broad.mit.edu	37	chr2	54856191	54856191	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctggaagagtcccgccgcctCtggaagttcttctgggagat	13	11	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:54856191C>T	uc002rxu.2	+	14	2169	c.1920C>T	c.(1918-1920)CTC>CTT	p.L640L	SPTBN1_uc002rxv.1_Silent_p.L640L|SPTBN1_uc002rxx.2_Silent_p.L627L	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	640	Spectrin 4.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CCCGCCGCCTCTGGAAGTTCT	0.592													0	0	0	0.086207	0	37	132										T	54856191	C	T	54856191	2	4	109	1	0	0	0	0	0	0	0	1	15118	900	32	1		1	SPTBN1	2	54856191	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	689061	54856191	188343182	46	33217										
SNRNP200	23020	broad.mit.edu	37	chr2	96957605	96957605	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatggccctggctgtctttcCagtctccttccgggagtgga	13	12	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:96957605C>T	uc002svu.2	-	17	2280	c.2194G>A	c.(2194-2196)GGA>AGA	p.G732R	SNRNP200_uc002svw.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	732	Helicase C-terminal 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						GCTGTCTTTCCAGTCTCCTTC	0.567													0	0	0	0.105934	0	13	52										T	96957605	C	T	96957605	3	4	109	1	0	0	0	0	1	0	0	0	14852	603	21	2	4332	2	SNRNP200	2	96957605	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	42101414	96957605	146241768	47	33218										
MAP4K4	9448	broad.mit.edu	37	chr2	102493575	102493575	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatttcaacaaatggacgtaCttgagggcttgaatgtcttg	11	6	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:102493575C>T	uc002tbg.2	+	24	2972	c.2917C>T	c.(2917-2919)CTT>TTT	p.L973F	MAP4K4_uc002tbc.2_Missense_Mutation_p.L1054F|MAP4K4_uc002tbd.2_Missense_Mutation_p.L946F|MAP4K4_uc002tbe.2_Missense_Mutation_p.L892F|MAP4K4_uc002tbf.2_Missense_Mutation_p.L1007F|MAP4K4_uc010yvy.1_Missense_Mutation_p.L969F|MAP4K4_uc002tbh.2_Missense_Mutation_p.L891F|MAP4K4_uc002tbi.2_Missense_Mutation_p.L776F|MAP4K4_uc010yvz.1_Missense_Mutation_p.L1013F|MAP4K4_uc002tbk.2_Missense_Mutation_p.L428F|MAP4K4_uc002tbl.2_Missense_Mutation_p.L159F	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	973	CNH.|Mediates interaction with RAP2A.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AATGGACGTACTTGAGGGCTT	0.433													0	0	0	0.083992	0	24	37										T	102493575	C	T	102493575	3	4	109	1	0	0	0	0	1	0	0	0	9262	565	20	2	3262	2	MAP4K4	2	102493575	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	5535970	102493575	140705798	48	33219										
RANBP2	5903	broad.mit.edu	37	chr2	109384816	109384816	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccaacggaagaatcttcaatCaactacacatttaaaacacc	3	12	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:109384816C>G	uc002tem.3	+	20	7947	c.7821C>G	c.(7819-7821)ATC>ATG	p.I2607M		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2607					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AATCTTCAATCAACTACACAT	0.328													0	0	0	0.139131	0	69	220										G	109384816	C	G	109384816	3	3	109	1	0	0	0	0	1	0	0	0	13028	816	29	1	7899	1	RANBP2	2	109384816	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	6891241	109384816	133814557	49	33220										
PCDP1	200373	broad.mit.edu	37	chr2	120413990	120413990	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggccggagagaagctgctcGaggagatgaggaacctgcgg	18	8	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:120413990G>A	uc002tmb.2	+	25	2701	c.1609G>A	c.(1609-1611)GAG>AAG	p.E537K		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	823						cilium	calmodulin binding				0	Colorectal(110;0.196)					GAAGCTGCTCGAGGAGATGAG	0.473													0	0	0	0.080935	0	10	45										A	120413990	G	A	120413990	3	1	109	1	0	0	0	0	1	0	0	0	11572	1059	37	1	1671	1	PCDP1	2	120413990	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	11029174	120413990	122785383	50	33221										
LIMS2	55679	broad.mit.edu	37	chr2	128399744	128399744	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggcagtagagctcacccttCagctcgcgggcctcggctgt	13	14	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:128399744C>A	uc002tpa.2	-	6	706	c.540G>T	c.(538-540)CTG>CTT	p.L180L	LIMS2_uc002tou.2_5'UTR|LIMS2_uc002tov.2_Silent_p.L28L|LIMS2_uc002tow.2_Silent_p.L28L|LIMS2_uc002tox.2_Silent_p.L204L|LIMS2_uc010fmb.2_Silent_p.L90L|LIMS2_uc002toy.2_Silent_p.L175L|LIMS2_uc010yzm.1_Silent_p.L202L|LIMS2_uc002toz.2_Silent_p.L175L|LIMS2_uc002tpb.2_Silent_p.L175L	NM_001161403	NP_001154875	Q7Z4I7	LIMS2_HUMAN	LIM and senescent cell antigen-like domains 2	180	LIM zinc-binding 3.				cell junction assembly	cytosol|focal adhesion|nucleus	zinc ion binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0681)		GCTCACCCTTCAGCTCGCGGG	0.692													1	0	0.00307968	0.038147	0.00348035	8	11										A	128399744	C	A	128399744	2	1	109	1	0	0	0	0	0	0	0	1	8804	813	29	3		3	LIMS2	2	128399744	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	7985754	128399744	114799629	51	33222										
GPR17	2840	broad.mit.edu	37	chr2	128408752	128408752	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gctccgcaggcccctctacgCacacctggcctgtgccttcc	9	20	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:128408752C>A	uc010yzn.1	+	4	1138	c.527C>A	c.(526-528)GCA>GAA	p.A176E	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Missense_Mutation_p.A176E|GPR17_uc010yzo.1_Missense_Mutation_p.A148E|GPR17_uc002tpd.2_Missense_Mutation_p.A148E	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	176	Helical; Name=4; (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		CCCCTCTACGCACACCTGGCC	0.642													1	0	3.30712e-30	0.139131	3.9596e-30	65	96										A	128408752	C	A	128408752	3	1	109	1	0	0	0	0	1	0	0	0	6667	710	25	4	533	4	GPR17	2	128408752	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	9008	128408752	114790621	52	33223										
WDR33	55339	broad.mit.edu	37	chr2	128464101	128464101	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cgcccagatttgggcactctCtgagcaggtcctgggccccc	12	16	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:128464101C>G	uc002tpg.1	-	22	3990	c.3807G>C	c.(3805-3807)CAG>CAC	p.Q1269H		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1269					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGGGCACTCTCTGAGCAGGTC	0.517													0	0	0	0.0333	0	17	79										G	128464101	C	G	128464101	3	3	109	1	0	0	0	0	1	0	0	0	17284	912	32	1	207	1	WDR33	2	128464101	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	55349	128464101	114735272	53	33224										
LRP1B	53353	broad.mit.edu	37	chr2	140990860	140990860	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cagttttgcccatccatataTaattttgcatataccggatt	5	9	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:140990860T>C	uc002tvj.1	-	91	14667	c.13695A>G	c.(13693-13695)TTA>TTG	p.L4565L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4565	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATCCATATATAATTTTGCAT	0.333										TSP Lung(27;0.18)			0	0	0	0.125774	0	26	14										C	140990860	T	C	140990860	2	2	109	1	0	0	0	0	0	0	0	1	8955	1403	49	5		5	LRP1B	2	140990860	Silent	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	12526759	140990860	102208513	54	33225										
NEB	4703	broad.mit.edu	37	chr2	152510589	152510589	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atagcctttcttcaaagcttCttcccatccaagtttataga	4	11	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:152510589C>T	uc010fnx.2	-	52	7023	c.6832G>A	c.(6832-6834)GAA>AAA	p.E2278K		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2278	Nebulin 60.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCAAAGCTTCTTCCCATCCA	0.333													0	0	0	0.080935	0	12	38										T	152510589	C	T	152510589	3	4	109	1	0	0	0	0	1	0	0	0	10302	922	32	1	19378	1	NEB	2	152510589	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	11519729	152510589	90688784	55	33226										
PRPF40A	55660	broad.mit.edu	37	chr2	153515522	153515522	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttgactttttataacttctCtctgagtagcacaaaaggat	6	7	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:153515522C>G	uc002tyh.3	-	24	2530	c.2508G>C	c.(2506-2508)GAG>GAC	p.E836D	PRPF40A_uc002tyg.3_Missense_Mutation_p.E292D|PRPF40A_uc010zcd.1_Missense_Mutation_p.E787D	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	863					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						TATAACTTCTCTCTGAGTAGC	0.323													0	0	0	0.014758	0	5	15										G	153515522	C	G	153515522	3	3	109	1	0	0	0	0	1	0	0	0	12571	927	32	1	296	1	PRPF40A	2	153515522	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1004933	153515522	89683851	56	33227										
SCN3A	6328	broad.mit.edu	37	chr2	166003408	166003408	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgctctctctgtcttcttttCttccttcggttcctccattc	4	15	5	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:166003408C>T	uc002ucx.2	-	12	2004	c.1512G>A	c.(1510-1512)AAG>AAA	p.K504K	SCN3A_uc002ucy.2_Silent_p.K504K|SCN3A_uc002ucz.2_Silent_p.K504K|SCN3A_uc002uda.1_Silent_p.K373K|SCN3A_uc002udb.1_Silent_p.K373K	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	504						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GTCTTCTTTTCTTCCTTCGGT	0.438													0	0	0	0.069456	0	38	148										T	166003408	C	T	166003408	2	4	109	1	0	0	0	0	0	0	0	1	13918	912	32	1		1	SCN3A	2	166003408	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	12487886	166003408	77195965	57	33228										
SCN3A	6328	broad.mit.edu	37	chr2	166019259	166019259	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccaatgagagcaaacacgctCagacagaacacagtcaggat	9	11	2	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:166019259C>G	uc002ucx.2	-	8	1266	c.774G>C	c.(772-774)CTG>CTC	p.L258L	SCN3A_uc002ucy.2_Silent_p.L258L|SCN3A_uc002ucz.2_Silent_p.L258L|SCN3A_uc002uda.1_Silent_p.L127L|SCN3A_uc002udb.1_Silent_p.L127L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	258	Helical; Name=S5 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CAAACACGCTCAGACAGAACA	0.483													0	0	0	0.083992	0	23	82										G	166019259	C	G	166019259	2	3	109	1	0	0	0	0	0	0	0	1	13918	813	29	1		1	SCN3A	2	166019259	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	15851	166019259	77180114	58	33229										
GALNT3	2591	broad.mit.edu	37	chr2	166627186	166627186	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atgtcttttaatgtgtaattTtactagtcgctttaggtgag	9	4	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:166627186T>A	uc010fph.1	-	2	412	c.25A>T	c.(25-27)AAA>TAA	p.K9*	GALNT3_uc010fpi.1_Nonsense_Mutation_p.K9*|GALNT3_uc002udi.2_Nonsense_Mutation_p.K9*	NM_004482	NP_004473	Q14435	GALT3_HUMAN	polypeptide N-acetylgalactosaminyltransferase 3	9	Cytoplasmic (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(2)|ovary(1)	3						ATGTGTAATTTTACTAGTCGC	0.284													0	0	0	0.069456	0	35	46										A	166627186	T	A	166627186	4	1	109	1	0	0	0	0	0	1	0	0	6214	1850	64	5	1916	5	GALNT3	2	166627186	Nonsense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	607927	166627186	76572187	59	33230										
SCN9A	6335	broad.mit.edu	37	chr2	167151173	167151173	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttccaagtaataaaaatattCtgttgaagaagaatttgaac	6	4	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:167151173C>T	uc010fpl.2	-	8	1243	c.902_splice	c.e8-1	p.K301_splice	uc002udp.2_RNA|SCN9A_uc002udr.1_Splice_Site_p.K172_splice|SCN9A_uc002uds.1_Splice_Site_p.K172_splice|SCN9A_uc002udt.1_Splice_Site_p.K172_splice	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TAAAAATATTCTGTTGAAGAA	0.303													0	0	0	0.021553	0	6	31										T	167151173	C	T	167151173	5	4	109	1	0	0	0	0	0	0	1	0	13925	927	32	1	5112	1	SCN9A	2	167151173	Splice_Site	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	523987	167151173	76048200	60	33231										
CDCA7	83879	broad.mit.edu	37	chr2	174231089	174231089	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acccagactgctggggcgttCgaggccagttctgtggcccc	14	14	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:174231089C>T	uc002uid.1	+	7	1008	c.877C>T	c.(877-879)CGA>TGA	p.R293*	CDCA7_uc002uic.1_Nonsense_Mutation_p.R372*|CDCA7_uc010zej.1_Nonsense_Mutation_p.R328*|CDCA7_uc010zek.1_Nonsense_Mutation_p.R251*	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	293	Mediates transcriptional activity.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			CTGGGGCGTTCGAGGCCAGTT	0.522													0	0	0	0.064281	0	38	71										T	174231089	C	T	174231089	4	4	109	1	0	0	0	0	0	1	0	0	3090	876	31	1	1144	1	CDCA7	2	174231089	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	7079916	174231089	68968284	61	33232										
TTN	7273	broad.mit.edu	37	chr2	179451491	179451491	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gctaaggtggcactgttcttGgtcatttcagtcacttctaa	9	9	5	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:179451491G>A	uc010zfg.1	-	257	56657	c.56433C>T	c.(56431-56433)ACC>ACT	p.T18811T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T12506T|TTN_uc010zfi.1_Silent_p.T12439T|TTN_uc010zfj.1_Silent_p.T12314T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19738							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGTTCTTGGTCATTTCAG	0.448													0	0	0	0.139131	0	57	82										A	179451491	G	A	179451491	2	1	109	1	0	0	0	0	0	0	0	1	16732	1335	47	2		2	TTN	2	179451491	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	5220402	179451491	63747882	62	33233										
TTN	7273	broad.mit.edu	37	chr2	179473525	179473525	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttgtctttcttttccaaagTgtagtttatgatttcactgc	6	8	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:179473525T>C	uc010zfg.1	-	223	44733	c.44509A>G	c.(44509-44511)ACT>GCT	p.T14837A	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T8532A|TTN_uc010zfi.1_Missense_Mutation_p.T8465A|TTN_uc010zfj.1_Missense_Mutation_p.T8340A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15764							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCCAAAGTGTAGTTTATG	0.378													0	0	0	0.055883	0	20	83										C	179473525	T	C	179473525	3	2	109	1	0	0	0	0	1	0	0	0	16732	1696	59	5	55836	5	TTN	2	179473525	Missense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	22034	179473525	63725848	63	33234										
ITGA4	3676	broad.mit.edu	37	chr2	182360109	182360109	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atcctccagatgtagcagttGgtgcttttcggtctgattct	10	9	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:182360109G>C	uc002unu.2	+	13	2114	c.1351G>C	c.(1351-1353)GGT>CGT	p.G451R		NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	451	FG-GAP 7.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGTAGCAGTTGGTGCTTTTCG	0.348													0	0	0	0.11126	0	40	75										C	182360109	G	C	182360109	3	2	109	1	0	0	0	0	1	0	0	0	7878	1348	47	4	1401	4	ITGA4	2	182360109	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2886584	182360109	60839264	64	33235										
CLK1	1195	broad.mit.edu	37	chr2	201726128	201726128	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtgtagtcatttctgtactCatcaatgtagcgtcgactat	8	8	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:201726128C>T	uc002uwe.2	-	3	404	c.223G>A	c.(223-225)GAG>AAG	p.E75K	CLK1_uc010zhi.1_Missense_Mutation_p.E117K|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_5'UTR|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	75					cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TTTCTGTACTCATCAATGTAG	0.373													0	0	0	0.083992	0	26	88										T	201726128	C	T	201726128	3	4	109	1	0	0	0	0	1	0	0	0	3536	835	29	1	1275	1	CLK1	2	201726128	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	19366019	201726128	41473245	65	33236										
ICA1L	130026	broad.mit.edu	37	chr2	203650663	203650663	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttgttaatttctttggactCtgtgaaggcactggctggtt	11	7	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:203650663C>G	uc002uzh.1	-	13	1475	c.1311G>C	c.(1309-1311)CAG>CAC	p.Q437H	ICA1L_uc002uzi.1_Missense_Mutation_p.Q437H	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	437											0						TCTTTGGACTCTGTGAAGGCA	0.328													0	0	0	0.104719	0	38	79										G	203650663	C	G	203650663	3	3	109	1	0	0	0	0	1	0	0	0	7478	912	32	1	145	1	ICA1L	2	203650663	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1924535	203650663	39548710	66	33237										
WDR12	55759	broad.mit.edu	37	chr2	203765749	203765749	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gataagaatttgaacttactGatgagatgttctccatttcc	7	7	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:203765749G>A	uc002uzl.2	-	3	980	c.230C>T	c.(229-231)TCA>TTA	p.S77L	WDR12_uc010ftt.2_Missense_Mutation_p.S77L	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	77					cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TGAACTTACTGATGAGATGTT	0.383													0	0	0	0.021553	0	6	33										A	203765749	G	A	203765749	3	1	109	1	0	0	0	0	1	0	0	0	17271	1304	45	1	1085	1	WDR12	2	203765749	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	115086	203765749	39433624	67	33238										
PARD3B	117583	broad.mit.edu	37	chr2	206480357	206480357	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cctcagcactacccacccccGccagctccccagcacaaagg	6	22	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:206480357G>A	uc002var.1	+	23	3645	c.3438G>A	c.(3436-3438)CCG>CCA	p.P1146P	PARD3B_uc002vao.1_Silent_p.P1045P|PARD3B_uc002vap.1_Silent_p.P1084P|PARD3B_uc002vaq.1_Silent_p.P1077P|uc010fuc.1_5'Flank	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1146	Poly-Pro.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		ACCCACCCCCGCCAGCTCCCC	0.617													0	0	0	0.062417	0	22	76										A	206480357	G	A	206480357	2	1	109	1	0	0	0	0	0	0	0	1	11444	1074	38	2		2	PARD3B	2	206480357	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2714608	206480357	36719016	68	33239										
GPR1	2825	broad.mit.edu	37	chr2	207041526	207041526	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcagagagttcttgagggttCgatgccgatgagataagaca	13	6	2	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:207041526C>A	uc002vbl.3	-	3	832	c.446G>T	c.(445-447)CGA>CTA	p.R149L	GPR1_uc010fue.2_Missense_Mutation_p.R149L|GPR1_uc010fuf.2_Missense_Mutation_p.R149L	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	149	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		CTTGAGGGTTCGATGCCGATG	0.463													1	0	1.67942e-08	0.038395	1.94251e-08	17	48										A	207041526	C	A	207041526	3	1	109	1	0	0	0	0	1	0	0	0	6621	884	31	3	625	3	GPR1	2	207041526	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	561169	207041526	36157847	69	33240										
GMPPA	29926	broad.mit.edu	37	chr2	220367145	220367145	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aactacggctgcatcgttgaGaatccacagacacacgaggt	10	11	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:220367145G>A	uc002vlr.2	+	6	539	c.471G>A	c.(469-471)GAG>GAA	p.E157E	GMPPA_uc002vls.2_Silent_p.E157E|GMPPA_uc002vlt.2_Silent_p.E157E|GMPPA_uc002vlu.2_Silent_p.E157E|GMPPA_uc002vlv.2_Silent_p.E157E|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Silent_p.E157E	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	157					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		GCATCGTTGAGAATCCACAGA	0.582													0	0	0	0.069234	0	10	24										A	220367145	G	A	220367145	2	1	109	1	0	0	0	0	0	0	0	1	6494	933	33	1		1	GMPPA	2	220367145	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	13325619	220367145	22832228	70	33241										
SPHKAP	80309	broad.mit.edu	37	chr2	228883342	228883342	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttggttctgtctccctccttCtgatggtctccttagaaagg	9	11	4	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:228883342C>T	uc002vpq.2	-	7	2275	c.2228G>A	c.(2227-2229)AGA>AAA	p.R743K	SPHKAP_uc002vpp.2_Missense_Mutation_p.R743K|SPHKAP_uc010zlx.1_Missense_Mutation_p.R743K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	743						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCCCTCCTTCTGATGGTCTC	0.473													0	0	0	0.014758	0	5	125										T	228883342	C	T	228883342	3	4	109	1	0	0	0	0	1	0	0	0	15047	913	32	1	2898	1	SPHKAP	2	228883342	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	8516197	228883342	14316031	71	33242										
SPHKAP	80309	broad.mit.edu	37	chr2	228973649	228973649	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctccagcaggctattgctgcGaagaacctggaggaacccag	12	12	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:228973649G>A	uc002vpq.2	-	3	192	c.145C>T	c.(145-147)CGC>TGC	p.R49C	SPHKAP_uc002vpp.2_Missense_Mutation_p.R49C|SPHKAP_uc010zlx.1_Missense_Mutation_p.R49C	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	49						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTATTGCTGCGAAGAACCTGG	0.413													0	0	0	0.124865	0	46	67										A	228973649	G	A	228973649	3	1	109	1	0	0	0	0	1	0	0	0	15047	1058	37	1	4997	1	SPHKAP	2	228973649	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	90307	228973649	14225724	72	33243										
DGKD	8527	broad.mit.edu	37	chr2	234358738	234358738	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcccaccactgtcccacagcGagagcttcggggtccccaag	11	17	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:234358738G>A	uc002vui.1	+	16	2011	c.1999G>A	c.(1999-2001)GAG>AAG	p.E667K	DGKD_uc002vuj.1_Missense_Mutation_p.E623K|DGKD_uc010fyh.1_Missense_Mutation_p.E534K|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	667					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GTCCCACAGCGAGAGCTTCGG	0.622													0	0	0	0.038147	0	6	38										A	234358738	G	A	234358738	3	1	109	1	0	0	0	0	1	0	0	0	4467	1059	37	1	2085	1	DGKD	2	234358738	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	5385089	234358738	8840635	73	33244										
AGAP1	116987	broad.mit.edu	37	chr2	236617866	236617866	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggacgctgagtcgatctgtCccggagctcaaagtggtgag	15	9	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:236617866C>T	uc002vvs.2	+	2	802	c.207C>T	c.(205-207)GTC>GTT	p.V69V	AGAP1_uc002vvt.2_Silent_p.V69V	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	69	Small GTPase-like.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						GTCGATCTGTCCCGGAGCTCA	0.557													0	0	0	0.139131	0	43	151										T	236617866	C	T	236617866	2	4	109	1	0	0	0	0	0	0	0	1	366	842	30	1		1	AGAP1	2	236617866	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2259128	236617866	6581507	74	33245										
ASB18	401036	broad.mit.edu	37	chr2	237150037	237150037	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	catgaggggcttcagatggtCgaggtcccctgcgaccaggg	16	11	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:237150037C>T	uc010znh.1	-	2	214	c.214G>A	c.(214-216)GAC>AAC	p.D72N	ASB18_uc010fyp.1_Missense_Mutation_p.D43N	NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	72					intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		TTCAGATGGTCGAGGTCCCCT	0.517													0	0	0	0.099896	0	26	28										T	237150037	C	T	237150037	3	4	109	1	0	0	0	0	1	0	0	0	1022	884	31	1	1205	1	ASB18	2	237150037	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	532171	237150037	6049336	75	33246										
ANO7	50636	broad.mit.edu	37	chr2	242128095	242128095	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccaccctctgtcccgcagtGaggacgggactctactgccg	11	17	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr2:242128095G>A	uc002wax.2	+	1	172	c.69G>A	c.(67-69)GTG>GTA	p.V23V	ANO7_uc002waw.2_Silent_p.V23V	NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	23	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GTCCCGCAGTGAGGACGGGAC	0.677													0	0	0	0.108266	0	26	34										A	242128095	G	A	242128095	2	1	109	1	0	0	0	0	0	0	0	1	702	1277	45	1		1	ANO7	2	242128095	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	4978058	242128095	1071278	76	33247										
SETD5	55209	broad.mit.edu	37	chr3	9517349	9517349	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcttccacgtcctattccagCcccgcccaccctgtgtccac	5	21	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:9517349C>A	uc003brt.2	+	23	4338	c.3903C>A	c.(3901-3903)AGC>AGA	p.S1301R	SETD5_uc003bru.2_Missense_Mutation_p.S1203R|SETD5_uc003brv.2_Missense_Mutation_p.S1190R|SETD5_uc010hck.2_Missense_Mutation_p.S783R|SETD5_uc003brx.2_Missense_Mutation_p.S970R	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	1301	Ser-rich.									ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CCTATTCCAGCCCCGCCCACC	0.547													1	0	6.94344e-10	0.038395	8.11595e-10	13	52										A	9517349	C	A	9517349	3	1	109	1	0	0	0	0	1	0	0	0	14134	738	26	4	3985	4	SETD5	3	9517349	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		9517349	188505081	77	33248										
MLH1	4292	broad.mit.edu	37	chr3	37092133	37092133	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgatctatacaaagtctttGagaggtgttaaatatggtta	9	4	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:37092133G>C	uc003cgl.2	+	19	2320	c.2260G>C	c.(2260-2262)GAG>CAG	p.E754Q	MLH1_uc011aye.1_Intron|MLH1_uc011ayb.1_Missense_Mutation_p.E513Q|MLH1_uc010hge.2_Missense_Mutation_p.E685Q|MLH1_uc003cgn.3_Missense_Mutation_p.E513Q|MLH1_uc011ayc.1_Missense_Mutation_p.E656Q|MLH1_uc011ayd.1_Missense_Mutation_p.E513Q|MLH1_uc003cgo.2_Missense_Mutation_p.E513Q|MLH1_uc010hgk.2_Missense_Mutation_p.E341Q|MLH1_uc010hgn.2_Missense_Mutation_p.L250F|MLH1_uc010hgm.2_RNA|MLH1_uc010hgo.2_3'UTR|MLH1_uc010hgp.2_Missense_Mutation_p.E137Q|MLH1_uc010hgq.2_RNA	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	754					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						CAAAGTCTTTGAGAGGTGTTA	0.383		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.11911	0	13	51										C	37092133	G	C	37092133	3	2	109	1	0	0	0	0	1	0	0	0	9617	1291	45	1	2334	1	MLH1	3	37092133	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	27574784	37092133	160930297	78	33249										
CELSR3	1951	broad.mit.edu	37	chr3	48697790	48697790	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	attcagtcgtaggtggtactCcttcattgtgaactcaggcc	10	10	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:48697790C>T	uc003cul.2	-	1	2559	c.2278G>A	c.(2278-2280)GAG>AAG	p.E760K	CELSR3_uc003cuf.1_Missense_Mutation_p.E830K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	760	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGGTGGTACTCCTTCATTGTG	0.567													0	0	0	0.0333	0	17	53										T	48697790	C	T	48697790	3	4	109	1	0	0	0	0	1	0	0	0	3223	864	30	1	7800	1	CELSR3	3	48697790	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	11605657	48697790	149324640	79	33250										
GRM2	2912	broad.mit.edu	37	chr3	51751819	51751819	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgctgctgccagggccagctCcagccttggccaaggtcagt	13	14	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:51751819C>T	uc010hlv.2	+	5	2770	c.2531C>T	c.(2530-2532)TCC>TTC	p.S844F	GRM2_uc003dbo.3_Missense_Mutation_p.S226F|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	844	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	AGGGCCAGCTCCAGCCTTGGC	0.627													0	0	0	0.105934	0	13	44										T	51751819	C	T	51751819	3	4	109	1	0	0	0	0	1	0	0	0	6797	855	30	1	2545	1	GRM2	3	51751819	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3054029	51751819	146270611	80	33251										
EPHA6	285220	broad.mit.edu	37	chr3	96706267	96706267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	caaaccaaaacaactggcttCgtacaaactggatctcccgt	6	13	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:96706267C>T	uc010how.1	+	3	587	c.544C>T	c.(544-546)CGT>TGT	p.R182C	EPHA6_uc003drp.1_Missense_Mutation_p.R182C	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	87	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CAACTGGCTTCGTACAAACTG	0.428													0	0	0	0.076483	0	24	150										T	96706267	C	T	96706267	3	4	109	1	0	0	0	0	1	0	0	0	5171	884	31	1	554	1	EPHA6	3	96706267	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	44954448	96706267	101316163	81	33252										
FILIP1L	11259	broad.mit.edu	37	chr3	99567199	99567199	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtgatagtaatactgctggtGactttattggttgttttgtt	11	3	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:99567199G>A	uc003dtm.2	-	5	3784	c.3321C>T	c.(3319-3321)GTC>GTT	p.V1107V	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Silent_p.V1107V|FILIP1L_uc010hpf.2_Silent_p.V683V|FILIP1L_uc010hpg.2_Silent_p.V867V|FILIP1L_uc003dtn.2_Silent_p.V867V|FILIP1L_uc003dtp.1_Silent_p.V867V	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	1107						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						TACTGCTGGTGACTTTATTGG	0.458													0	0	0	0.069456	0	37	153										A	99567199	G	A	99567199	2	1	109	1	0	0	0	0	0	0	0	1	5895	1277	45	1		1	FILIP1L	3	99567199	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2860932	99567199	98455231	82	33253										
ZBTB11	27107	broad.mit.edu	37	chr3	101378715	101378715	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atgttcttccacatatggaaCatataaattcccgcttggtt	6	9	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:101378715C>T	uc003dve.3	-	6	2188	c.1958G>A	c.(1957-1959)TGT>TAT	p.C653Y		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	653	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ACATATGGAACATATAAATTC	0.413													0	0	0	0.049695	0	21	86										T	101378715	C	T	101378715	3	4	109	1	0	0	0	0	1	0	0	0	17521	478	17	2	1227	2	ZBTB11	3	101378715	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1811516	101378715	96643715	83	33254										
GTPBP8	29083	broad.mit.edu	37	chr3	112709949	112709949	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcacgtcccaagcttttgctGaggtgctgcggctgccgaag	14	12	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:112709949G>A	uc003dzn.2	+	1	150	c.103G>A	c.(103-105)GAG>AAG	p.E35K	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Missense_Mutation_p.E35K	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	35					barrier septum formation		GTP binding				0						AGCTTTTGCTGAGGTGCTGCG	0.632													0	0	0	0.0918	0	24	59										A	112709949	G	A	112709949	3	1	109	1	0	0	0	0	1	0	0	0	6884	1291	45	1	105	1	GTPBP8	3	112709949	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	11331234	112709949	85312481	84	33255										
IQCB1	9657	broad.mit.edu	37	chr3	121491405	121491405	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aagtaaaatgagcacatactCattagctgttcaacgttggt	8	7	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:121491405C>G	uc010hre.1	-	14	1781	c.1566G>C	c.(1564-1566)ATG>ATC	p.M522I	IQCB1_uc003eek.2_Missense_Mutation_p.M389I|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	522					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		AGCACATACTCATTAGCTGTT	0.443													0	0	0	0.125774	0	25	103										G	121491405	C	G	121491405	3	3	109	1	0	0	0	0	1	0	0	0	7803	840	29	1	238	1	IQCB1	3	121491405	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	8781456	121491405	76531025	85	33256										
MUC13	56667	broad.mit.edu	37	chr3	124646788	124646788	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gctactgtaggaccactagtCgcagtttctgtggttgttac	11	9	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:124646788C>G	uc003ehq.1	-	2	126	c.102G>C	c.(100-102)GCG>GCC	p.A34A		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	34	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						GACCACTAGTCGCAGTTTCTG	0.453													0	0	0	0.0918	0	25	100										G	124646788	C	G	124646788	2	3	109	1	0	0	0	0	0	0	0	1	9971	871	31	1		1	MUC13	3	124646788	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3155383	124646788	73375642	86	33257										
COL6A6	131873	broad.mit.edu	37	chr3	130289928	130289928	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtggcagtacttatactgctGaggcactgggcttctcagac	12	10	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:130289928G>A	uc010htl.2	+	6	2699	c.2668G>A	c.(2668-2670)GAG>AAG	p.E890K		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	890	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TTATACTGCTGAGGCACTGGG	0.537													0	0	0	0.009096	0	4	22										A	130289928	G	A	130289928	3	1	109	1	0	0	0	0	1	0	0	0	3703	1291	45	1	2690	1	COL6A6	3	130289928	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	5643140	130289928	67732502	87	33258										
CCDC39	339829	broad.mit.edu	37	chr3	180349347	180349347	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcatatctattcttcagcttCtcaattttacttagccgctc	3	12	5	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:180349347C>T	uc010hxe.2	-	14	2023	c.1908G>A	c.(1906-1908)GAG>GAA	p.E636E	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	636					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCTTCAGCTTCTCAATTTTAC	0.338													0	0	0	0.108266	0	27	20										T	180349347	C	T	180349347	2	4	109	1	0	0	0	0	0	0	0	1	2811	912	32	1		1	CCDC39	3	180349347	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	50059419	180349347	17673083	88	33259										
MCCC1	56922	broad.mit.edu	37	chr3	182788887	182788887	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgttcttgaaattcttgttCtgatctaacaatcctcattc	4	10	5	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:182788887C>G	uc003fle.2	-	7	798	c.661G>C	c.(661-663)GAA>CAA	p.E221Q	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.E104Q|MCCC1_uc003flg.2_Missense_Mutation_p.E112Q|MCCC1_uc011bqp.1_Missense_Mutation_p.E174Q|MCCC1_uc011bqq.1_Missense_Mutation_p.E112Q	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	221	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	AATTCTTGTTCTGATCTAACA	0.383													0	0	0	0.105934	0	12	58										G	182788887	C	G	182788887	3	3	109	1	0	0	0	0	1	0	0	0	9374	922	32	1	1568	1	MCCC1	3	182788887	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2439540	182788887	15233543	89	33260										
MCCC1	56922	broad.mit.edu	37	chr3	182789047	182789047	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcatgacaggatagccaattCtcctggcgtgttccttcagg	10	11	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:182789047C>G	uc003fle.2	-	6	727	c.590G>C	c.(589-591)AGA>ACA	p.R197T	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.R80T|MCCC1_uc003flg.2_Missense_Mutation_p.R88T|MCCC1_uc011bqp.1_Missense_Mutation_p.R150T|MCCC1_uc011bqq.1_Missense_Mutation_p.R88T	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	197	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	ATAGCCAATTCTCCTGGCGTG	0.483													0	0	0	0.125774	0	30	75										G	182789047	C	G	182789047	3	3	109	1	0	0	0	0	1	0	0	0	9374	913	32	1	1643	1	MCCC1	3	182789047	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	160	182789047	15233383	90	33261										
MCCC1	56922	broad.mit.edu	37	chr3	182790262	182790262	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttctgagagaaaaccgcatCctggatggatagcctagaaa	10	8	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:182790262C>G	uc003fle.2	-	5	520	c.383G>C	c.(382-384)GGA>GCA	p.G128A	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Intron|MCCC1_uc003flg.2_Missense_Mutation_p.G19A|MCCC1_uc011bqp.1_Missense_Mutation_p.G81A|MCCC1_uc011bqq.1_Missense_Mutation_p.G19A	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	128	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	AAAACCGCATCCTGGATGGAT	0.398													0	0	0	0.02938	0	7	39										G	182790262	C	G	182790262	3	3	109	1	0	0	0	0	1	0	0	0	9374	855	30	1	1854	1	MCCC1	3	182790262	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1215	182790262	15232168	91	33262										
AHSG	197	broad.mit.edu	37	chr3	186337720	186337720	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcagtgacctgcatggtgttCcaaacacaggtaacagctcc	10	12	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:186337720C>G	uc003fqk.3	+	6	831	c.750C>G	c.(748-750)TTC>TTG	p.F250L	AHSG_uc003fql.3_Missense_Mutation_p.F251L|AHSG_uc003fqm.3_Missense_Mutation_p.F249L|AHSG_uc010hyp.2_Missense_Mutation_p.F213L	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	250	Cystatin fetuin-A-type 2.				acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GCATGGTGTTCCAAACACAGG	0.458													0	0	0	0.038395	0	16	49										G	186337720	C	G	186337720	3	3	109	1	0	0	0	0	1	0	0	0	420	854	30	1	772	1	AHSG	3	186337720	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3547458	186337720	11684710	92	33263										
TNK2	10188	broad.mit.edu	37	chr3	195594701	195594701	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggtcttcccaggtgagcttGagagccggggtggcagcggg	19	9	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr3:195594701G>C	uc003fvu.1	-	12	2966	c.2423C>G	c.(2422-2424)TCA>TGA	p.S808*	TNK2_uc003fvq.1_Nonsense_Mutation_p.S215*|TNK2_uc003fvr.1_Nonsense_Mutation_p.S333*|TNK2_uc003fvs.1_Nonsense_Mutation_p.S840*|TNK2_uc003fvt.1_Nonsense_Mutation_p.S886*|TNK2_uc010hzw.1_RNA	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	808	Pro-rich.|EBD domain (By similarity).			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	AGGTGAGCTTGAGAGCCGGGG	0.711													0	0	0	0.038147	0	7	41										C	195594701	G	C	195594701	4	2	109	1	0	0	0	0	0	1	0	0	16315	1294	45	1	709	1	TNK2	3	195594701	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	9256981	195594701	2427729	93	33264										
RGS12	6002	broad.mit.edu	37	chr4	3441290	3441290	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggcatagcgggggcacaggCtggccctgggaggtcgcagg	20	10	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:3441290C>T	uc003ggw.2	+	18	5127	c.4223C>T	c.(4222-4224)GCT>GTT	p.A1408V	RGS12_uc003ggz.2_Missense_Mutation_p.A760V|RGS12_uc003gha.2_Missense_Mutation_p.A750V|RGS12_uc010icv.2_Missense_Mutation_p.A607V|HGFAC_uc003ghc.2_5'Flank|HGFAC_uc010icw.2_5'Flank	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1408						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGGGCACAGGCTGGCCCTGGG	0.662													0	0	0	0.021553	0	6	24										T	3441290	C	T	3441290	3	4	109	1	0	0	0	0	1	0	0	0	13295	797	28	2	4364	2	RGS12	4	3441290	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		3441290	187712986	94	33265										
C4orf19	55286	broad.mit.edu	37	chr4	37592524	37592524	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccatggctccgatggagatGgggatggggagattgtggac	18	7	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:37592524G>A	uc003gsw.3	+	4	1030	c.847G>A	c.(847-849)GGG>AGG	p.G283R	RELL1_uc003gsz.2_3'UTR|C4orf19_uc003gsy.3_Missense_Mutation_p.G283R	NM_001104629	NP_001098099	Q8IY42	CD019_HUMAN	hypothetical protein LOC55286	283											0						CGATGGAGATGGGGATGGGGA	0.532													0	0	0	0.139131	0	68	92										A	37592524	G	A	37592524	3	1	109	1	0	0	0	0	1	0	0	0	2253	1348	47	2	853	2	C4orf19	4	37592524	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	34151234	37592524	153561752	95	33266										
EXOC1	55763	broad.mit.edu	37	chr4	56768625	56768625	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtcattaaggagtaccctgGaaaggaagtaaaaaaaggtc	11	5	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:56768625G>A	uc003hbe.1	+	18	2611	c.2453G>A	c.(2452-2454)GGA>GAA	p.G818E	EXOC1_uc003hbf.1_Missense_Mutation_p.G818E|EXOC1_uc003hbg.1_Missense_Mutation_p.G803E	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	818					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					GAGTACCCTGGAAAGGAAGTA	0.388													0	0	0	0.058154	0	10	46										A	56768625	G	A	56768625	3	1	109	1	0	0	0	0	1	0	0	0	5301	1174	41	1	2519	1	EXOC1	4	56768625	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	19176101	56768625	134385651	96	33267										
POLR2B	5431	broad.mit.edu	37	chr4	57860643	57860643	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggaaagagatggtgctccttCaccaatgatgcccaatgaag	11	9	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:57860643C>T	uc003hcl.1	+	4	360	c.317C>T	c.(316-318)TCA>TTA	p.S106L	POLR2B_uc011cae.1_Missense_Mutation_p.S99L|POLR2B_uc011caf.1_Missense_Mutation_p.S31L	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	106					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GGTGCTCCTTCACCAATGATG	0.338													0	0	0	0.038147	0	8	24										T	57860643	C	T	57860643	3	4	109	1	0	0	0	0	1	0	0	0	12215	838	29	1	331	1	POLR2B	4	57860643	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1092018	57860643	133293633	97	33268										
LPHN3	23284	broad.mit.edu	37	chr4	62845433	62845433	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atccacaagaacctctgcatCagtctctttgtagcagagct	7	12	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:62845433C>G	uc010ihh.2	+	15	2927	c.2754C>G	c.(2752-2754)ATC>ATG	p.I918M	LPHN3_uc003hcq.3_Missense_Mutation_p.I918M|LPHN3_uc003hct.2_Missense_Mutation_p.I311M	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	905	Helical; Name=2; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ACCTCTGCATCAGTCTCTTTG	0.458													0	0	0	0.11911	0	13	184										G	62845433	C	G	62845433	3	3	109	1	0	0	0	0	1	0	0	0	8917	816	29	1	2812	1	LPHN3	4	62845433	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4984790	62845433	128308843	98	33269										
TET2	54790	broad.mit.edu	37	chr4	106156981	106156981	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccagaaaacaacacagctgGagcacaagtcacaaatgtac	7	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:106156981G>A	uc003hxk.2	+	3	2268	c.1882G>A	c.(1882-1884)GAG>AAG	p.E628K	TET2_uc011cez.1_Missense_Mutation_p.E649K|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.E628K|TET2_uc003hxi.1_Missense_Mutation_p.E628K	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	628	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.L590_H650del(1)		haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AACACAGCTGGAGCACAAGTC	0.478			Mis N|F		MDS								0	0	0	0.014758	0	5	29										A	106156981	G	A	106156981	3	1	109	1	0	0	0	0	1	0	0	0	15767	1175	41	1	1884	1	TET2	4	106156981	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	43311548	106156981	84997295	99	33270										
KIAA1109	84162	broad.mit.edu	37	chr4	123277009	123277009	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gagaatagcactactgtgaaGaattctagtttgttgagtgg	12	4	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:123277009G>C	uc003ieh.2	+	81	14409	c.14364G>C	c.(14362-14364)AAG>AAC	p.K4788N	KIAA1109_uc003iem.2_Missense_Mutation_p.K1144N	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4788					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTACTGTGAAGAATTCTAGTT	0.363													0	0	0	0.043863	0	19	29										C	123277009	G	C	123277009	3	2	109	1	0	0	0	0	1	0	0	0	8208	933	33	1	14686	1	KIAA1109	4	123277009	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	17120028	123277009	67877267	100	33271										
RXFP1	59350	broad.mit.edu	37	chr4	159547979	159547979	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttttatgttccagggaccttGaaggcaaccatatccataat	7	9	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr4:159547979G>A	uc003ipz.2	+	10	845	c.763G>A	c.(763-765)GAA>AAA	p.E255K	RXFP1_uc010iqj.1_Missense_Mutation_p.E84K|RXFP1_uc011cja.1_Intron|RXFP1_uc010iqo.2_Missense_Mutation_p.E255K|RXFP1_uc011cjb.1_Missense_Mutation_p.E201K|RXFP1_uc010iqk.2_Missense_Mutation_p.E123K|RXFP1_uc011cjc.1_Missense_Mutation_p.E174K|RXFP1_uc011cjd.1_Missense_Mutation_p.E174K|RXFP1_uc010iql.2_Intron|RXFP1_uc011cje.1_Missense_Mutation_p.E282K|RXFP1_uc010iqm.2_Missense_Mutation_p.E222K|RXFP1_uc011cjf.1_Missense_Mutation_p.E125K|RXFP1_uc010iqn.2_Missense_Mutation_p.E201K	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	255	Extracellular (Potential).|LRR 5.					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CAGGGACCTTGAAGGCAACCA	0.264													0	0	0	0.069234	0	10	14										A	159547979	G	A	159547979	3	1	109	1	0	0	0	0	1	0	0	0	13759	1291	45	1	801	1	RXFP1	4	159547979	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	36270970	159547979	31606297	101	33272										
KIAA0947	23379	broad.mit.edu	37	chr5	5489267	5489267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaaatttcttttcagatataCcatggggtatacagttagca	8	6	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:5489267C>T	uc003jdm.3	+	19	6847	c.6625C>T	c.(6625-6627)CCA>TCA	p.P2209S		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2209										ovary(1)|central_nervous_system(1)	2						TTCAGATATACCATGGGGTAT	0.383													0	0	0	0.038147	0	7	42										T	5489267	C	T	5489267	3	4	109	1	0	0	0	0	1	0	0	0	8202	507	18	2	6699	2	KIAA0947	5	5489267	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		5489267	175425993	102	33273										
ADAMTS12	81792	broad.mit.edu	37	chr5	33683979	33683979	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cataccatgttcatgatggtGaggatgtaggactccacatt	10	8	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:33683979G>A	uc003jia.1	-	4	979	c.816C>T	c.(814-816)CTC>CTT	p.L272L	ADAMTS12_uc010iuq.1_Silent_p.L272L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	272	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCATGATGGTGAGGATGTAGG	0.468										HNSCC(64;0.19)			0	0	0	0.050027	0	30	83										A	33683979	G	A	33683979	2	1	109	1	0	0	0	0	0	0	0	1	257	1277	45	1		1	ADAMTS12	5	33683979	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	28194712	33683979	147231281	103	33274										
MCTP1	79772	broad.mit.edu	37	chr5	94248593	94248593	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aatccatggccttgaggtctCtcccttcaatcaaggtgatg	9	11	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:94248593C>T	uc003kkx.2	-	9	1439	c.1439G>A	c.(1438-1440)AGA>AAA	p.R480K	MCTP1_uc003kkv.2_Missense_Mutation_p.R259K|MCTP1_uc003kkw.2_Missense_Mutation_p.R213K|MCTP1_uc003kkz.2_Missense_Mutation_p.R141K|MCTP1_uc003kku.2_5'UTR	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	480	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CTTGAGGTCTCTCCCTTCAAT	0.468													0	0	0	0.139131	0	56	39										T	94248593	C	T	94248593	3	4	109	1	0	0	0	0	1	0	0	0	9400	913	32	1	1620	1	MCTP1	5	94248593	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	60564614	94248593	86666667	104	33275										
RGMB	285704	broad.mit.edu	37	chr5	98115321	98115321	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcccaatgtcgaatccagaaAtgcaccacggacttcgtgtc	9	13	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:98115321A>G	uc003knc.2	+	4	699	c.297A>G	c.(295-297)AAA>AAG	p.K99K	RGMB_uc003knb.2_Silent_p.K99K	NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	58					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		GAATCCAGAAATGCACCACGG	0.493													0	0	0	0.139131	0	91	82										G	98115321	A	G	98115321	2	3	109	1	0	0	0	0	0	0	0	1	13281	98	4	5		5	RGMB	5	98115321	Silent	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	3866728	98115321	82799939	105	33276										
RAD50	10111	broad.mit.edu	37	chr5	131925368	131925368	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgaaacaaaaacagatagatGagataagagataagaaaact	8	3	0	6			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:131925368G>C	uc003kxi.2	+	9	1678	c.1291G>C	c.(1291-1293)GAG>CAG	p.E431Q	RAD50_uc003kxh.2_Missense_Mutation_p.E292Q	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	431	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAGATAGATGAGATAAGAGA	0.284								Homologous_recombination					0	0	0	0.038147	0	7	20										C	131925368	G	C	131925368	3	2	109	1	0	0	0	0	1	0	0	0	12984	1291	45	1	1325	1	RAD50	5	131925368	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	33810047	131925368	48989892	106	33277			3	151		4	3	112	N	G	7.229205e-07
RAD50	10111	broad.mit.edu	37	chr5	131925439	131925439	+	Silent	SNP	G	G	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaaatcctaagtaagaagcaGaatgagctgaaaaatgtgaa							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:131925439G>A	uc003kxi.2	+	9	1749	c.1362G>A	c.(1360-1362)CAG>CAA	p.Q454Q	RAD50_uc003kxh.2_Silent_p.Q315Q	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	454	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTAAGAAGCAGAATGAGCTGA	0.353								Homologous_recombination					0	0	0	0.080935	0	10	18										A	131925439	G	A	131925439	2	1	109	1	0	0	0	0	0	0	0	1	12984	933	33	1		1	RAD50	5	131925439	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	71	131925439	48989821	107	33278	167	2	3	151		4	3	112	N	G	7.229205e-07
RAD50	10111	broad.mit.edu	37	chr5	131925448	131925448	+	Silent	SNP	G	G	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtaagaagcagaatgagctGaaaaatgtgaagtatgaatt							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:131925448G>A	uc003kxi.2	+	9	1758	c.1371G>A	c.(1369-1371)CTG>CTA	p.L457L	RAD50_uc003kxh.2_Silent_p.L318L	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	457	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGAATGAGCTGAAAAATGTGA	0.343								Homologous_recombination					0	0	0	0.080935	0	10	21										A	131925448	G	A	131925448	2	1	109	1	0	0	0	0	0	0	0	1	12984	1277	45	1		1	RAD50	5	131925448	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	9	131925448	48989812	108	33279	167	2	3	151		4	3	112	N	G	7.229205e-07
RAD50	10111	broad.mit.edu	37	chr5	131925479	131925479	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtatgaattacagcagttgGaaggatcttcagacaggatt	11	5	2	2	rs145031602	byFrequency	TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:131925479G>A	uc003kxi.2	+	9	1789	c.1402G>A	c.(1402-1404)GAA>AAA	p.E468K	RAD50_uc003kxh.2_Missense_Mutation_p.E329K	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	468	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACAGCAGTTGGAAGGATCTTC	0.318								Homologous_recombination					0	0	0	0.132662	0	11	18										A	131925479	G	A	131925479	3	1	109	1	0	0	0	0	1	0	0	0	12984	1175	41	1	1436	1	RAD50	5	131925479	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	31	131925479	48989781	109	33280			3	151		4	3	112	N	G	7.229205e-07
SIL1	64374	broad.mit.edu	37	chr5	138386694	138386694	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgcctctctttccccagtctGaagattcagccgtacgtggg	10	13	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:138386694G>A	uc003ldm.2	-	3	303	c.286C>T	c.(286-288)CAG>TAG	p.Q96*	SIL1_uc003ldn.2_Nonsense_Mutation_p.Q95*|SIL1_uc003ldo.2_Nonsense_Mutation_p.Q96*|SIL1_uc003ldp.2_Nonsense_Mutation_p.Q96*	NM_022464	NP_071909	Q9H173	SIL1_HUMAN	SIL1 protein precursor	96	Interaction with HSPA5 and localization to the endoplasmic reticulum (By similarity).				intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCCCCAGTCTGAAGATTCAGC	0.493									Marinesco-Sj_gren_syndrome				0	0	0	0.139131	0	47	82										A	138386694	G	A	138386694	4	1	109	1	0	0	0	0	0	1	0	0	14321	1299	45	1	1127	1	SIL1	5	138386694	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6461215	138386694	42528566	110	33281										
PCDHGA1	56114	broad.mit.edu	37	chr5	140711698	140711698	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccacgacttggacagcaatGagaatgcacaaatcacttac	7	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:140711698G>A	uc003lji.1	+	1	1447	c.1447G>A	c.(1447-1449)GAG>AAG	p.E483K	PCDHGA1_uc011dan.1_Missense_Mutation_p.E483K	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	483	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACAGCAATGAGAATGCACA	0.537													0	0	0	0.092188	0	39	97										A	140711698	G	A	140711698	3	1	109	1	0	0	0	0	1	0	0	0	11550	1291	45	1	1449	1	PCDHGA1	5	140711698	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2325004	140711698	40203562	111	33282										
PCDHGA5	56110	broad.mit.edu	37	chr5	140745310	140745310	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aatcccagaggtgtctctatCttctctgtgacagcccatga	8	12	3	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:140745310C>G	uc003lju.1	+	1	1413	c.1413C>G	c.(1411-1413)ATC>ATG	p.I471M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.I471M	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	471	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTCTCTATCTTCTCTGTGA	0.542													0	0	0	0.054565	0	33	120										G	140745310	C	G	140745310	3	3	109	1	0	0	0	0	1	0	0	0	11557	903	32	1	1415	1	PCDHGA5	5	140745310	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	33612	140745310	40169950	112	33283										
PCDHGA8	9708	broad.mit.edu	37	chr5	140772943	140772943	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cgtgcagactggagacaatgGagccataaacccagagctgg	13	10	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr5:140772943G>C	uc003lkd.1	+	1	1461	c.563G>C	c.(562-564)GGA>GCA	p.G188A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.G188A	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	188	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGACAATGGAGCCATAAAC	0.632													0	0	0	0.080935	0	12	32										C	140772943	G	C	140772943	3	2	109	1	0	0	0	0	1	0	0	0	11560	1174	41	1	565	1	PCDHGA8	5	140772943	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	27633	140772943	40142317	113	33284										
PECI	10455	broad.mit.edu	37	chr6	4131046	4131046	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	catgcgtcccatttggccttGttgatcaagtcaaatacacc	7	12	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:4131046G>A	uc003mwf.2	-	3	304	c.267C>T	c.(265-267)AAC>AAT	p.N89N	PECI_uc003mwc.2_5'UTR|PECI_uc003mwd.2_Silent_p.N59N|PECI_uc003mwe.2_5'UTR|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	89	ACB.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				ATTTGGCCTTGTTGATCAAGT	0.448													0	0	0	0.117977	0	39	139										A	4131046	G	A	4131046	2	1	109	1	0	0	0	0	0	0	0	1	11716	1368	48	2		2	PECI	6	4131046	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		4131046	166984021	114	33285										
DSP	1832	broad.mit.edu	37	chr6	7583321	7583321	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cagagggagattgataaactCagacagcgcccatatgggtc	12	9	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:7583321C>A	uc003mxp.1	+	24	6105	c.5826C>A	c.(5824-5826)CTC>CTA	p.L1942L	DSP_uc003mxq.1_Silent_p.L1343L	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1942	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTGATAAACTCAGACAGCGCC	0.522													1	0	8.24728e-16	0.099896	9.79503e-16	26	52										A	7583321	C	A	7583321	2	1	109	1	0	0	0	0	0	0	0	1	4781	813	29	3		3	DSP	6	7583321	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3452275	7583321	163531746	115	33286										
HIVEP1	3096	broad.mit.edu	37	chr6	12123020	12123020	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggtagccatgagagaacctGagcacagccctgtgcccggc	13	13	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:12123020G>A	uc003nac.2	+	4	3171	c.2992G>A	c.(2992-2994)GAG>AAG	p.E998K	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	998					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GAGAGAACCTGAGCACAGCCC	0.463													0	0	0	0.038147	0	7	209										A	12123020	G	A	12123020	3	1	109	1	0	0	0	0	1	0	0	0	7186	1291	45	1	3002	1	HIVEP1	6	12123020	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	4539699	12123020	158992047	116	33287										
NOL7	51406	broad.mit.edu	37	chr6	13620657	13620657	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tagtaaataagttcctgtctCttgccaacaagaggttacca	7	9	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:13620657C>T	uc003naz.2	+	7	672	c.640C>T	c.(640-642)CTT>TTT	p.L214F		NM_016167	NP_057251	Q9UMY1	NOL7_HUMAN	nucleolar protein 7, 27kDa	214						mitochondrion|nucleolus					0	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.135)	Epithelial(50;0.176)			GTTCCTGTCTCTTGCCAACAA	0.333													0	0	0	0.038395	0	15	53										T	13620657	C	T	13620657	3	4	109	1	0	0	0	0	1	0	0	0	10526	913	32	1	666	1	NOL7	6	13620657	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1497637	13620657	157494410	117	33288										
CAP2	10486	broad.mit.edu	37	chr6	17426839	17426839	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggtgtggcaccctccgtggAagcctttgacaagctgatgg	14	10	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:17426839A>G	uc003ncb.2	+	3	383	c.140A>G	c.(139-141)GAA>GGA	p.E47G	CAP2_uc010jpk.1_RNA|CAP2_uc011dja.1_Missense_Mutation_p.E47G|CAP2_uc011djb.1_Missense_Mutation_p.E47G|CAP2_uc011djc.1_Missense_Mutation_p.E47G|CAP2_uc011djd.1_Missense_Mutation_p.E47G	NM_006366	NP_006357	P40123	CAP2_HUMAN	adenylyl cyclase-associated protein 2	47					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			CCCTCCGTGGAAGCCTTTGAC	0.448													0	0	0	0.059317	0	30	56										G	17426839	A	G	17426839	3	3	109	1	0	0	0	0	1	0	0	0	2620	246	9	5	146	5	CAP2	6	17426839	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	3806182	17426839	153688228	118	33289										
TRIM38	10475	broad.mit.edu	37	chr6	25972225	25972225	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	caacagactctgagtagactGagggactatgaggctggtct	13	8	2	5			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:25972225G>A	uc003nfm.2	+	5	1071	c.636G>A	c.(634-636)CTG>CTA	p.L212L	TRIM38_uc003nfn.2_Silent_p.L194L|TRIM38_uc010jqd.2_5'Flank	NM_006355	NP_006346	O00635	TRI38_HUMAN	tripartite motif-containing 38	212					positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding				0						TGAGTAGACTGAGGGACTATG	0.488													0	0	0	0.144211	0	32	58										A	25972225	G	A	25972225	2	1	109	1	0	0	0	0	0	0	0	1	16509	1277	45	1		1	TRIM38	6	25972225	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	8545386	25972225	145142842	119	33290										
HIST1H3B	8358	broad.mit.edu	37	chr6	26031885	26031885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtgactttacatttacgctCtttctccgcgaatgcggcga	9	11	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:26031885C>G	uc003nfs.1	-	1	404	c.404G>C	c.(403-405)AGA>ACA	p.R135T		NM_003537	NP_003528	P68431	H31_HUMAN	histone cluster 1, H3b	135				Missing (in Ref. 2; AAA52651).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						CATTTACGCTCTTTCTCCGCG	0.453													0	0	0	0.049695	0	20	71										G	26031885	C	G	26031885	3	3	109	1	0	0	0	0	1	0	0	0	7156	913	32	1	10	1	HIST1H3B	6	26031885	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	59660	26031885	145083182	120	33291										
HIST1H2BC	8347	broad.mit.edu	37	chr6	26123851	26123851	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggcgcacggccgtctggatCtccctggaggtgatggtcga	16	11	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:26123851C>T	uc003ngk.3	-	1	304	c.282G>A	c.(280-282)GAG>GAA	p.E94E	HIST1H2BC_uc003ngl.2_Silent_p.E94E|HIST1H2AC_uc003ngm.2_5'Flank|HIST1H2AC_uc003ngn.2_5'Flank|HIST1H2AC_uc003ngo.2_5'Flank|HIST1H2AC_uc003ngp.2_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	histone cluster 1, H2bc	94					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1						CCGTCTGGATCTCCCTGGAGG	0.597													0	0	0	0.083992	0	24	153										T	26123851	C	T	26123851	2	4	109	1	0	0	0	0	0	0	0	1	7142	912	32	1		1	HIST1H2BC	6	26123851	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	91966	26123851	144991216	121	33292										
GABBR1	2550	broad.mit.edu	37	chr6	29576387	29576387	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cacctcctcacctggcagacGaaaggaaactggttcctccc	8	16	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:29576387G>A	uc003nmt.3	-	16	2319	c.1983C>T	c.(1981-1983)TTC>TTT	p.F661F	GABBR1_uc003nmp.3_Silent_p.F544F|GABBR1_uc003nms.3_Silent_p.F544F|GABBR1_uc003nmu.3_Silent_p.F599F|GABBR1_uc011dlr.1_Silent_p.F484F|GABBR1_uc011dls.1_3'UTR	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	661	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	CCTGGCAGACGAAAGGAAACT	0.547													0	0	0	0.132662	0	15	73										A	29576387	G	A	29576387	2	1	109	1	0	0	0	0	0	0	0	1	6155	1049	37	1		1	GABBR1	6	29576387	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3452536	29576387	141538680	122	33293										
LSM2	57819	broad.mit.edu	37	chr6	31766264	31766264	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tatatctcacctgatccacaGaatggagggttccacagatg	9	10	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:31766264G>A	uc003nxg.2	-	3	301	c.92C>T	c.(91-93)TCT>TTT	p.S31F	VARS_uc003nxe.2_5'Flank|VARS_uc011doi.1_5'Flank	NM_021177	NP_067000	Q9Y333	LSM2_HUMAN	LSM2 homolog, U6 small nuclear RNA associated	31					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytosol|nucleoplasm	U6 snRNA binding				0						CTGATCCACAGAATGGAGGGT	0.473													0	0	0	0.125774	0	28	55										A	31766264	G	A	31766264	3	1	109	1	0	0	0	0	1	0	0	0	9056	942	33	1	207	1	LSM2	6	31766264	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2189877	31766264	139348803	123	33294										
EHMT2	10919	broad.mit.edu	37	chr6	31847893	31847893	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agggggcagggagccgagctCgggcagcagctcagggtgtg	21	9	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:31847893C>G	uc003nxz.1	-	28	3611	c.3601G>C	c.(3601-3603)GAG>CAG	p.E1201Q	EHMT2_uc003nxv.1_Missense_Mutation_p.E240Q|EHMT2_uc003nxw.1_Missense_Mutation_p.E240Q|EHMT2_uc003nxx.1_Missense_Mutation_p.E399Q|EHMT2_uc003nxy.1_Missense_Mutation_p.E999Q|EHMT2_uc011don.1_Missense_Mutation_p.E1224Q|EHMT2_uc003nya.1_Missense_Mutation_p.E1167Q|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dol.1_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1201					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GAGCCGAGCTCGGGCAGCAGC	0.652													0	0	0	0.014758	0	5	45										G	31847893	C	G	31847893	3	3	109	1	0	0	0	0	1	0	0	0	4984	893	31	1	35	1	EHMT2	6	31847893	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	81629	31847893	139267174	124	33295										
ZBTB12	221527	broad.mit.edu	37	chr6	31867740	31867740	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	taatctcggccacactggccTccagcacgttctcggccgtg	10	16	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:31867740T>A	uc003nyd.1	-	2	1519	c.1343A>T	c.(1342-1344)GAG>GTG	p.E448V	EHMT2_uc011don.1_5'Flank|EHMT2_uc003nxz.1_5'Flank|EHMT2_uc003nya.1_5'Flank|EHMT2_uc003nyb.1_5'Flank|C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACACTGGCCTCCAGCACGTT	0.652													0	0	0	0.045705	0	30	42										A	31867740	T	A	31867740	3	1	109	1	0	0	0	0	1	0	0	0	17522	1551	54	5	40	5	ZBTB12	6	31867740	Missense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	19847	31867740	139247327	125	33296										
C6orf10	10665	broad.mit.edu	37	chr6	32261160	32261160	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttggcacatctgcctcagtCttctctacttggccttcttg	7	13	5	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:32261160C>G	uc011dpy.1	-	12	1463	c.1290G>C	c.(1288-1290)AAG>AAC	p.K430N	C6orf10_uc011dpx.1_Missense_Mutation_p.K212N	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	430						integral to membrane				skin(1)	1						CTGCCTCAGTCTTCTCTACTT	0.468													0	0	0	0.069456	0	39	213										G	32261160	C	G	32261160	3	3	109	1	0	0	0	0	1	0	0	0	2317	912	32	1	405	1	C6orf10	6	32261160	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	393420	32261160	138853907	126	33297										
C6orf10	10665	broad.mit.edu	37	chr6	32261600	32261600	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cattcctattttgtctttctCtaaatcagtgccttttcctt	3	11	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:32261600C>G	uc011dpy.1	-	12	1023	c.850G>C	c.(850-852)GAG>CAG	p.E284Q	C6orf10_uc011dpx.1_Missense_Mutation_p.E66Q	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	284						integral to membrane				skin(1)	1						TTGTCTTTCTCTAAATCAGTG	0.388													0	0	0	0.038147	0	8	280										G	32261600	C	G	32261600	3	3	109	1	0	0	0	0	1	0	0	0	2317	922	32	1	845	1	C6orf10	6	32261600	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	440	32261600	138853467	127	33298										
ZBTB22	9278	broad.mit.edu	37	chr6	33283569	33283569	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttggaggactcacagaagttGacctgctcctcccccttgtc	9	14	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:33283569G>A	uc003oeb.2	-	2	1277	c.1125C>T	c.(1123-1125)GTC>GTT	p.V375V	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.V375V	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	375					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CACAGAAGTTGACCTGCTCCT	0.602													0	0	0	0.125774	0	28	131										A	33283569	G	A	33283569	2	1	109	1	0	0	0	0	0	0	0	1	17527	1277	45	1		1	ZBTB22	6	33283569	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1021969	33283569	137831498	128	33299										
C6orf222	389384	broad.mit.edu	37	chr6	36298448	36298448	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tctccgccaggggcctccttGggcaccttggattctccatc	10	16	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:36298448G>C	uc003oly.2	-	2	198	c.20C>G	c.(19-21)CCA>CGA	p.P7R		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	7										skin(2)|ovary(1)|breast(1)	4						GGGCCTCCTTGGGCACCTTGG	0.478													0	0	0	0.11911	0	12	80										C	36298448	G	C	36298448	3	2	109	1	0	0	0	0	1	0	0	0	2356	1348	47	4	1982	4	C6orf222	6	36298448	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3014879	36298448	134816619	129	33300										
DNAH8	1769	broad.mit.edu	37	chr6	38840895	38840895	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	catggtctatatcagcagctCtgctctcagctggaggccaa	10	12	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:38840895C>G	uc003ooe.1	+	49	7400	c.6800C>G	c.(6799-6801)TCT>TGT	p.S2267C		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATCAGCAGCTCTGCTCTCAGC	0.502													0	0	0	0.083992	0	22	94										G	38840895	C	G	38840895	3	3	109	1	0	0	0	0	1	0	0	0	4607	913	32	1	6986	1	DNAH8	6	38840895	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2542447	38840895	132274172	130	33301										
TCTE1	202500	broad.mit.edu	37	chr6	44254253	44254253	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggtgttccgggagcatctgCttcaggatagggttttcttt	13	7	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:44254253C>T	uc003oxi.2	-	3	450	c.294G>A	c.(292-294)AAG>AAA	p.K98K	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	98										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGAGCATCTGCTTCAGGATAG	0.582													0	0	0	0.049695	0	20	112										T	44254253	C	T	44254253	2	4	109	1	0	0	0	0	0	0	0	1	15714	796	28	2		2	TCTE1	6	44254253	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	5413358	44254253	126860814	131	33302										
SNAP91	9892	broad.mit.edu	37	chr6	84303326	84303326	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aacggcaggagcaggagaagGagcagttgcgggaactggag	19	6	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:84303326G>C	uc011dze.1	-	17	1884	c.1567C>G	c.(1567-1569)CCT>GCT	p.P523A	SNAP91_uc011dzd.1_Missense_Mutation_p.P26A|SNAP91_uc003pkb.2_Missense_Mutation_p.P486A|SNAP91_uc003pkc.2_Missense_Mutation_p.P521A|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Missense_Mutation_p.P521A	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	523	Ala-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		gcaggagaaggagcagTTGCG	0.264													0	0	0	0.014758	0	3	6										C	84303326	G	C	84303326	3	2	109	1	0	0	0	0	1	0	0	0	14833	1174	41	1	1204	1	SNAP91	6	84303326	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	40049073	84303326	86811741	132	33303										
AIM1	202	broad.mit.edu	37	chr6	106968294	106968294	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaaatcacttagccactcctCaaaggccagatcagactgtt	7	12	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:106968294C>G	uc003prh.2	+	2	2474	c.1987C>G	c.(1987-1989)CAA>GAA	p.Q663E		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	663							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGCCACTCCTCAAAGGCCAGA	0.493													0	0	0	0.146539	0	16	68										G	106968294	C	G	106968294	3	3	109	1	0	0	0	0	1	0	0	0	430	827	29	1	1993	1	AIM1	6	106968294	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	22664968	106968294	64146773	133	33304										
RFX6	222546	broad.mit.edu	37	chr6	117241560	117241560	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atttgaacagcattggctctCaagcccttcttaccatttca	5	12	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:117241560C>G	uc003pxm.2	+	12	1333	c.1270C>G	c.(1270-1272)CAA>GAA	p.Q424E		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	424					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CATTGGCTCTCAAGCCCTTCT	0.383													0	0	0	0.108266	0	27	123										G	117241560	C	G	117241560	3	3	109	1	0	0	0	0	1	0	0	0	13267	827	29	1	1316	1	RFX6	6	117241560	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	10273266	117241560	53873507	134	33305										
C6orf204	387119	broad.mit.edu	37	chr6	118845073	118845073	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aataactttgacgagatgatCcagtcaaaacctgcagaaac	7	9	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:118845073C>G	uc003pxz.1	-	4	1619	c.1031G>C	c.(1030-1032)GGA>GCA	p.G344A	C6orf204_uc003pya.1_Missense_Mutation_p.G347A|C6orf204_uc003pyb.2_Missense_Mutation_p.G344A|C6orf204_uc011ebj.1_Missense_Mutation_p.G242A|C6orf204_uc003pyc.2_Missense_Mutation_p.G347A	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	344						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		ACGAGATGATCCAGTCAAAAC	0.269													0	0	0	0.062417	0	18	77										G	118845073	C	G	118845073	3	3	109	1	0	0	0	0	1	0	0	0	2353	855	30	1	1480	1	C6orf204	6	118845073	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1603513	118845073	52269994	135	33306										
MAP7	9053	broad.mit.edu	37	chr6	136667001	136667001	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaggcaagcttacctgcagtCtgctgtgtctgaacaccatc	10	12	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:136667001C>T	uc003qgz.2	-	17	2478	c.2232G>A	c.(2230-2232)CAG>CAA	p.Q744Q	MAP7_uc011edf.1_Silent_p.Q729Q|MAP7_uc011edg.1_Silent_p.Q774Q|MAP7_uc010kgu.2_Silent_p.Q766Q|MAP7_uc011edh.1_Silent_p.Q729Q|MAP7_uc010kgv.2_Silent_p.Q766Q|MAP7_uc010kgs.2_Silent_p.Q598Q|MAP7_uc011edi.1_Silent_p.Q598Q|MAP7_uc010kgq.1_Silent_p.Q650Q|MAP7_uc003qha.1_Silent_p.Q707Q	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	744					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		TACCTGCAGTCTGCTGTGTCT	0.488													0	0	0	0.047766	0	8	31										T	136667001	C	T	136667001	2	4	109	1	0	0	0	0	0	0	0	1	9266	912	32	1		1	MAP7	6	136667001	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	17821928	136667001	34448066	136	33307										
MTRF1L	54516	broad.mit.edu	37	chr6	153316427	153316427	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	caaatcattttcatctgtttCttctgagggaaccaaaagta	6	8	5	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:153316427C>A	uc003qpi.3	-	3	472	c.367G>T	c.(367-369)GAA>TAA	p.E123*	MTRF1L_uc003qpl.3_Nonsense_Mutation_p.E123*|MTRF1L_uc011efa.1_Nonsense_Mutation_p.E123*|MTRF1L_uc003qpj.3_5'UTR|MTRF1L_uc003qpk.3_Nonsense_Mutation_p.E123*	NM_019041	NP_061914	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor	123						mitochondrion	translation release factor activity, codon specific				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)		TCATCTGTTTCTTCTGAGGGA	0.294													1	0	0.00198382	0.02938	0.00224765	5	18										A	153316427	C	A	153316427	4	1	109	1	0	0	0	0	0	1	0	0	9960	922	32	3	795	3	MTRF1L	6	153316427	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	16649426	153316427	17798640	137	33308										
IGF2R	3482	broad.mit.edu	37	chr6	160431725	160431725	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttttttttaatagggaactCctgaatttgtaactgcaaca	6	6	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:160431725C>A	uc003qta.2	+	4	569	c.421C>A	c.(421-423)CCT>ACT	p.P141T		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	141	1.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATAGGGAACTCCTGAATTTGT	0.333													1	0	9.70103e-10	0.069234	1.13094e-09	9	33										A	160431725	C	A	160431725	3	1	109	1	0	0	0	0	1	0	0	0	7576	855	30	3	435	3	IGF2R	6	160431725	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	7115298	160431725	10683342	138	33309										
MAP3K4	4216	broad.mit.edu	37	chr6	161527688	161527688	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcctatgataatgttatgcaCgttggcttgaggaaggtgac	12	6	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr6:161527688C>G	uc003qtn.2	+	20	4141	c.3999C>G	c.(3997-3999)CAC>CAG	p.H1333Q	MAP3K4_uc010kkc.1_Missense_Mutation_p.H1329Q|MAP3K4_uc003qto.2_Missense_Mutation_p.H1283Q|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.H786Q|MAP3K4_uc003qtp.2_Missense_Mutation_p.H269Q|MAP3K4_uc003qtq.2_Missense_Mutation_p.H22Q	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1333					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ATGTTATGCACGTTGGCTTGA	0.398													0	0	0	0.014758	0	4	47										G	161527688	C	G	161527688	3	3	109	1	0	0	0	0	1	0	0	0	9252	535	19	4	4077	4	MAP3K4	6	161527688	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1095963	161527688	9587379	139	33310										
RADIL	55698	broad.mit.edu	37	chr7	4917471	4917471	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcctgcctggggtccagggcGtaccgctccagcgcctcctt	13	17	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:4917471G>T	uc003snj.1	-	2	473	c.300C>A	c.(298-300)TAC>TAA	p.Y100*	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	100	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GGTCCAGGGCGTACCGCTCCA	0.682													1	0	2.61681e-11	0.11911	3.08311e-11	14	95										T	4917471	G	T	4917471	4	4	109	1	0	0	0	0	0	1	0	0	12997	1140	40	4	2983	4	RADIL	7	4917471	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		4917471	154221192	140	33311										
DNAH11	8701	broad.mit.edu	37	chr7	21920409	21920409	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcctgtgttgctgggagactGaggtttggcccccagggctg	17	10	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:21920409G>A	uc003svc.2	+	76	12337	c.12306G>A	c.(12304-12306)CTG>CTA	p.L4102L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4102	AAA 6 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTGGGAGACTGAGGTTTGGCC	0.478									Kartagener_syndrome				0	0	0	0.092188	0	39	117										A	21920409	G	A	21920409	2	1	109	1	0	0	0	0	0	0	0	1	4599	1277	45	1		1	DNAH11	7	21920409	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	17002938	21920409	137218254	141	33312										
MGC87042	256227	broad.mit.edu	37	chr7	22533267	22533267	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aaagggtgaattacttccctCagaagagtgtaaagaaaagt	10	5	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:22533267C>T	uc003svh.2	-	3	313	c.216G>A	c.(214-216)CTG>CTA	p.L72L	MGC87042_uc010kum.1_Silent_p.L91L			Q6NZ63	STEAL_HUMAN	SubName: Full=cDNA FLJ60218, highly similar to Six transmembrane epithelial antigen ofprostate 1;	72	Helical; (Potential).					integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0						TTACTTCCCTCAGAAGAGTGT	0.403													0	0	0	0.132662	0	12	86										T	22533267	C	T	22533267	2	4	109	1	0	0	0	0	0	0	0	1	9554	813	29	1		1	MGC87042	7	22533267	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	612858	22533267	136605396	142	33313										
C7orf30	115416	broad.mit.edu	37	chr7	23349004	23349004	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgattcatttgatgcttccaGaaaccagagaaatctatgaa	7	7	2	5			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:23349004G>C	uc003swd.1	+	4	579	c.547G>C	c.(547-549)GAA>CAA	p.E183Q	C7orf30_uc003swe.2_RNA	NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	183						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			GATGCTTCCAGAAACCAGAGA	0.388													0	0	0	0.043863	0	18	93										C	23349004	G	C	23349004	3	2	109	1	0	0	0	0	1	0	0	0	2386	943	33	1	561	1	C7orf30	7	23349004	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	815737	23349004	135789659	143	33314										
PPP1R9A	55607	broad.mit.edu	37	chr7	94919414	94919414	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctttcttaggctcttggaatGacagcatcccaggaccgagc	10	12	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:94919414G>A	uc003unp.2	+	16	3378	c.3096G>A	c.(3094-3096)ATG>ATA	p.M1032I	PPP1R9A_uc010lfj.2_Missense_Mutation_p.M1308I|PPP1R9A_uc011kif.1_Missense_Mutation_p.M1230I|PPP1R9A_uc003unq.2_Missense_Mutation_p.M1187I|PPP1R9A_uc011kig.1_Missense_Mutation_p.M1024I|PPP1R9A_uc003unr.2_Missense_Mutation_p.M321I	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	1032	Interacts with TGN38 (By similarity).|SAM.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CTCTTGGAATGACAGCATCCC	0.413										HNSCC(28;0.073)			0	0	0	0.080935	0	11	51										A	94919414	G	A	94919414	3	1	109	1	0	0	0	0	1	0	0	0	12378	1290	45	1	4026	1	PPP1R9A	7	94919414	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	71570410	94919414	64219249	144	33315										
LAMB4	22798	broad.mit.edu	37	chr7	107674733	107674733	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgcccgtccttgagtgatttGagcttgttgtaactggttca	11	8	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:107674733G>C	uc010ljo.1	-	31	4822	c.4738C>G	c.(4738-4740)CAA>GAA	p.Q1580E	LAMB4_uc003vey.2_Missense_Mutation_p.Q1580E|LAMB4_uc010ljp.1_Missense_Mutation_p.Q549E	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1580	Potential.|Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGAGTGATTTGAGCTTGTTGT	0.328													0	0	0	0.11126	0	42	81										C	107674733	G	C	107674733	3	2	109	1	0	0	0	0	1	0	0	0	8613	1299	45	1	563	1	LAMB4	7	107674733	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	12755319	107674733	51463930	145	33316										
POT1	25913	broad.mit.edu	37	chr7	124503594	124503594	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgaagttaaaatacttgcttGaagtgcgaggtatgataggg	13	3	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:124503594G>A	uc003vlm.2	-	8	957	c.356C>T	c.(355-357)TCA>TTA	p.S119L	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_5'UTR|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	119					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						ATACTTGCTTGAAGTGCGAGG	0.423													0	0	0	0.105934	0	14	102										A	124503594	G	A	124503594	3	1	109	1	0	0	0	0	1	0	0	0	12260	1294	45	1	1596	1	POT1	7	124503594	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	16828861	124503594	34635069	146	33317										
NUP205	23165	broad.mit.edu	37	chr7	135262738	135262738	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttctatactgttttgatatCagttttatagagcaaagcac	6	7	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:135262738C>T	uc003vsw.2	+	6	874	c.843C>T	c.(841-843)ATC>ATT	p.I281I	NUP205_uc011kqa.1_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	281					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GTTTTGATATCAGTTTTATAG	0.363													0	0	0	0.069234	0	10	52										T	135262738	C	T	135262738	2	4	109	1	0	0	0	0	0	0	0	1	10759	816	29	1		1	NUP205	7	135262738	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	10759144	135262738	23875925	147	33318										
OR6B1	135946	broad.mit.edu	37	chr7	143701978	143701978	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	taagaaaccgagaggtcaagGaagctctgaagaaactggca	12	7	2	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:143701978G>T	uc003wdt.1	+	1	889	c.889G>T	c.(889-891)GAA>TAA	p.E297*		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					AGAGGTCAAGGAAGCTCTGAA	0.433													1	0	1.02788e-11	0.0333	1.21427e-11	16	64										T	143701978	G	T	143701978	4	4	109	1	0	0	0	0	0	1	0	0	11187	1175	41	3	891	3	OR6B1	7	143701978	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	8439240	143701978	15436685	148	33319										
ABP1	26	broad.mit.edu	37	chr7	150554983	150554983	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttctaccccaacggggtgatGgaggccaagatgcatgccac	12	12	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr7:150554983G>A	uc003why.1	+	3	5643	c.1425G>A	c.(1423-1425)ATG>ATA	p.M475I	ABP1_uc003whz.1_Missense_Mutation_p.M475I|ABP1_uc003wia.1_Missense_Mutation_p.M475I	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	475					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	ACGGGGTGATGGAGGCCAAGA	0.577													0	0	0	0.086207	0	38	71										A	150554983	G	A	150554983	3	1	109	1	0	0	0	0	1	0	0	0	98	1348	47	2	1427	2	ABP1	7	150554983	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6853005	150554983	8583680	149	33320										
TRIM35	23087	broad.mit.edu	37	chr8	27168708	27168708	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcgcagagcaactcctccttGaaggagcgggaaggcccggg	16	12	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:27168708G>C	uc003xfl.1	-	1	127	c.45C>G	c.(43-45)TTC>TTG	p.F15L	PTK2B_uc003xfn.1_5'Flank|PTK2B_uc003xfo.1_5'Flank|TRIM35_uc010lup.1_Missense_Mutation_p.F15L|TRIM35_uc003xfm.1_RNA	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	15					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		ACTCCTCCTTGAAGGAGCGGG	0.706													0	0	0	0.021553	0	5	5										C	27168708	G	C	27168708	3	2	109	1	0	0	0	0	1	0	0	0	16506	1281	45	1	1460	1	TRIM35	8	27168708	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		27168708	119195314	150	33321										
TRAM1	23471	broad.mit.edu	37	chr8	71508503	71508503	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctaaaaatgacttacgtcatCaggttatggggataagccct	9	8	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:71508503C>G	uc003xyo.1	-	5	650	c.480G>C	c.(478-480)CTG>CTC	p.L160L	TRAM1_uc011lfc.1_Silent_p.L129L	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	160	Helical; (Potential).|TLC.				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			CTTACGTCATCAGGTTATGGG	0.363													0	0	0	0.038395	0	19	79										G	71508503	C	G	71508503	2	3	109	1	0	0	0	0	0	0	0	1	16448	813	29	1		1	TRAM1	8	71508503	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	44339795	71508503	74855519	151	33322										
KCNB2	9312	broad.mit.edu	37	chr8	73848919	73848919	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agggaggctcttgagcgggcCaaaaggaacggaagcatcgt	16	8	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:73848919C>T	uc003xzb.2	+	3	1917	c.1329C>T	c.(1327-1329)GCC>GCT	p.A443A		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	443	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTGAGCGGGCCAAAAGGAACG	0.458													0	0	0	0.069288	0	21	95										T	73848919	C	T	73848919	2	4	109	1	0	0	0	0	0	0	0	1	8013	581	21	2		2	KCNB2	8	73848919	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2340416	73848919	72515103	152	33323										
FABP9	646480	broad.mit.edu	37	chr8	82373707	82373707	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cagttctttcatgtaatcctCaaagttttcactggagacca	6	10	4	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:82373707C>G	uc011lfo.1	-	1	52	c.52G>C	c.(52-54)GAG>CAG	p.E18Q		NM_001080526	NP_001073995	Q0Z7S8	FABP9_HUMAN	fatty acid binding protein 9, testis	18							lipid binding|transporter activity				0			Epithelial(68;0.186)			ATGTAATCCTCAAAGTTTTCA	0.393													0	0	0	0.116897	0	26	127										G	82373707	C	G	82373707	3	3	109	1	0	0	0	0	1	0	0	0	5363	835	29	1	361	1	FABP9	8	82373707	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	8524788	82373707	63990315	153	33324										
TMEM67	91147	broad.mit.edu	37	chr8	94767171	94767171	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcgcggtggggctggggtggCaatggcggtttggtccctct	20	9	1	0	rs146838062		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:94767171C>T	uc011lgk.1	+	1	100	c.29C>T	c.(28-30)GCA>GTA	p.A10V	TMEM67_uc010mau.2_Missense_Mutation_p.A10V|TMEM67_uc010mav.2_Missense_Mutation_p.A10V|TMEM67_uc010mat.1_Intron|TMEM67_uc010maw.2_Missense_Mutation_p.A10V|TMEM67_uc003yga.3_Intron	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	10	Helical; (Potential).				cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GCTGGGGTGGCAATGGCGGTT	0.642													0	0	0	0.099896	0	23	107										T	94767171	C	T	94767171	3	4	109	1	0	0	0	0	1	0	0	0	16193	710	25	2	31	2	TMEM67	8	94767171	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	12393464	94767171	51596851	154	33325										
DPYS	1807	broad.mit.edu	37	chr8	105463544	105463544	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctttgggatcagcccagcttCgccaggtctcgaaggcctca	11	14	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:105463544C>T	uc003yly.3	-	2	482	c.353G>A	c.(352-354)CGA>CAA	p.R118Q		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	118					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGCCCAGCTTCGCCAGGTCTC	0.522													0	0	0	0.02938	0	7	42										T	105463544	C	T	105463544	3	4	109	1	0	0	0	0	1	0	0	0	4746	884	31	1	1238	1	DPYS	8	105463544	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	10696373	105463544	40900478	155	33326										
RECQL4	9401	broad.mit.edu	37	chr8	145737627	145737627	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acatatctggtccttctcctCagcggtcaagtcccccgggc	9	16	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:145737627C>T	uc003zdj.2	-	19	3168	c.3136G>A	c.(3136-3138)GAG>AAG	p.E1046K		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	1046					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCCTTCTCCTCAGCGGTCAAG	0.637			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				0	0	0	0.105934	0	11	37										T	145737627	C	T	145737627	3	4	109	1	0	0	0	0	1	0	0	0	13202	835	29	1	506	1	RECQL4	8	145737627	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	40274083	145737627	626395	156	33327										
ARHGAP39	80728	broad.mit.edu	37	chr8	145770988	145770988	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttcttgatggactcgctgctCcaggccagcatgttggcgat	12	11	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr8:145770988C>G	uc003zdt.1	-	7	2721	c.2166G>C	c.(2164-2166)TGG>TGC	p.W722C	ARHGAP39_uc011llk.1_Missense_Mutation_p.W722C|ARHGAP39_uc003zds.1_Missense_Mutation_p.W722C	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	722	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						ACTCGCTGCTCCAGGCCAGCA	0.592													0	0	0	0.09319	0	12	33										G	145770988	C	G	145770988	3	3	109	1	0	0	0	0	1	0	0	0	884	856	30	1	1206	1	ARHGAP39	8	145770988	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	33361	145770988	593034	157	33328										
GLDC	2731	broad.mit.edu	37	chr9	6592946	6592946	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acactgaatcttcaaggtatCaaagaacaggtcatgctgga	9	8	4	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:6592946C>G	uc003zkc.2	-	10	1499	c.1306G>C	c.(1306-1308)GAT>CAT	p.D436H		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	436					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TTCAAGGTATCAAAGAACAGG	0.507													0	0	0	0.038395	0	18	90										G	6592946	C	G	6592946	3	3	109	1	0	0	0	0	1	0	0	0	6433	826	29	1	1820	1	GLDC	9	6592946	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		6592946	134620485	158	33329										
MPDZ	8777	broad.mit.edu	37	chr9	13176368	13176368	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgggtatatagttcctccaGagacatatgcagatcaagta	9	8	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:13176368G>C	uc010mia.1	-	19	2755	c.2698C>G	c.(2698-2700)CTG>GTG	p.L900V	MPDZ_uc003zkz.3_5'Flank|MPDZ_uc010mhy.2_Missense_Mutation_p.L900V|MPDZ_uc010mhz.2_Missense_Mutation_p.L900V|MPDZ_uc011lmn.1_Missense_Mutation_p.L900V|MPDZ_uc003zlb.3_Missense_Mutation_p.L900V	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	900					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		AGTTCCTCCAGAGACATATGC	0.378													0	0	0	0.009096	0	4	26										C	13176368	G	C	13176368	3	2	109	1	0	0	0	0	1	0	0	0	9722	933	33	1	3535	1	MPDZ	9	13176368	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6583422	13176368	128037063	159	33330										
ZCCHC7	84186	broad.mit.edu	37	chr9	37126696	37126696	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccatggtctttcttcttctCttcaatctaatgagctggtt	6	11	6	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:37126696C>T	uc003zzq.2	+	2	540	c.367C>T	c.(367-369)CTT>TTT	p.L123F	ZCCHC7_uc011lqh.1_Intron|ZCCHC7_uc011lqi.1_Missense_Mutation_p.L122F|ZCCHC7_uc010mlt.2_Missense_Mutation_p.L122F|ZCCHC7_uc003zzs.1_Missense_Mutation_p.L122F	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	123							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		TTCTTCTTCTCTTCAATCTAA	0.368													0	0	0	0.083992	0	25	196										T	37126696	C	T	37126696	3	4	109	1	0	0	0	0	1	0	0	0	17590	913	32	1	369	1	ZCCHC7	9	37126696	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	23950328	37126696	104086735	160	33331										
TRPM3	80036	broad.mit.edu	37	chr9	73230868	73230868	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttttcctttgtgggcttctCtggttcttctgcctccttct	7	12	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:73230868C>G	uc004aid.2	-	17	2690	c.2446G>C	c.(2446-2448)GAG>CAG	p.E816Q	TRPM3_uc004ahu.2_Missense_Mutation_p.E646Q|TRPM3_uc004ahv.2_Missense_Mutation_p.E618Q|TRPM3_uc004ahw.2_Missense_Mutation_p.E688Q|TRPM3_uc004ahx.2_Missense_Mutation_p.E675Q|TRPM3_uc004ahy.2_Missense_Mutation_p.E678Q|TRPM3_uc004ahz.2_Missense_Mutation_p.E665Q|TRPM3_uc004aia.2_Missense_Mutation_p.E663Q|TRPM3_uc004aib.2_Missense_Mutation_p.E653Q|TRPM3_uc004aic.2_Missense_Mutation_p.E816Q	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	841	Extracellular (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						GTGGGCTTCTCTGGTTCTTCT	0.458													0	0	0	0.062417	0	21	77										G	73230868	C	G	73230868	3	3	109	1	0	0	0	0	1	0	0	0	16584	922	32	1	2713	1	TRPM3	9	73230868	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	36104172	73230868	67982563	161	33332										
ALG2	85365	broad.mit.edu	37	chr9	101980827	101980827	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gactaggtcatccagcttttCaggaacaactgagtcaaagc	9	10	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:101980827C>T	uc004azf.2	-	2	710	c.640G>A	c.(640-642)GAA>AAA	p.E214K	ALG2_uc004azg.2_Missense_Mutation_p.E121K	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	214					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				TCCAGCTTTTCAGGAACAACT	0.448													0	0	0	0.0918	0	26	69										T	101980827	C	T	101980827	3	4	109	1	0	0	0	0	1	0	0	0	519	835	29	1	614	1	ALG2	9	101980827	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	28749959	101980827	39232604	162	33333										
ORM2	5005	broad.mit.edu	37	chr9	117093120	117093120	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tacctgaatgtccagcgggaGaatgggaccgtctccagata	12	10	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:117093120G>A	uc004bil.2	+	3	422	c.306G>A	c.(304-306)GAG>GAA	p.E102E	ORM1_uc011lxo.1_Intron	NM_000608	NP_000599	P19652	A1AG2_HUMAN	orosomucoid 2 precursor	102				E -> D (in Ref. 3; BAG35159).	acute-phase response|regulation of immune system process|transport	extracellular space	binding				0		Myeloproliferative disorder(63;0.163)				TCCAGCGGGAGAATGGGACCG	0.542													0	0	0	0.064281	0	32	18										A	117093120	G	A	117093120	2	1	109	1	0	0	0	0	0	0	0	1	11268	933	33	1		1	ORM2	9	117093120	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	15112293	117093120	24120311	163	33334										
SETX	23064	broad.mit.edu	37	chr9	135205429	135205429	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggaatgcaatgacagtgaaGatatcattgctgttcctttg	10	6	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:135205429G>A	uc004cbk.2	-	10	1739	c.1556C>T	c.(1555-1557)TCT>TTT	p.S519F	SETX_uc004cbj.2_Missense_Mutation_p.S138F|SETX_uc010mzt.2_Missense_Mutation_p.S138F	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	519					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGACAGTGAAGATATCATTGC	0.448													0	0	0	0.014758	0	5	142										A	135205429	G	A	135205429	3	1	109	1	0	0	0	0	1	0	0	0	14141	942	33	1	6545	1	SETX	9	135205429	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	18112309	135205429	6008002	164	33335										
TSC1	7248	broad.mit.edu	37	chr9	135778175	135778175	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgtaacttcaactgatctttCtagcagagaccagaaatgtc	7	9	3	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:135778175C>G	uc004cca.2	-	18	2443	c.2209_splice	c.e18-1	p.K737_splice	TSC1_uc004ccb.3_Splice_Site_p.K736_splice|TSC1_uc011mcq.1_Splice_Site_p.K686_splice|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1						activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		ACTGATCTTTCTAGCAGAGAC	0.423			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis		OREG0019577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.117977	0	45	24										G	135778175	C	G	135778175	5	3	109	1	0	0	0	0	0	0	1	0	16602	927	32	1	1310	1	TSC1	9	135778175	Splice_Site	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	572746	135778175	5435256	165	33336										
SEC16A	9919	broad.mit.edu	37	chr9	139358996	139358996	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcactgaaaatttttcaggaGaagttggtcttgatgaaact	10	5	2	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:139358996G>A	uc004chx.2	-	9	4631	c.4322C>T	c.(4321-4323)TCT>TTT	p.S1441F	SEC16A_uc004chv.3_Missense_Mutation_p.S831F|SEC16A_uc004chw.2_Missense_Mutation_p.S1441F|SEC16A_uc010nbn.2_Missense_Mutation_p.S1441F	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1263					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TTTTTCAGGAGAAGTTGGTCT	0.438													0	0	0	0.132662	0	16	44										A	139358996	G	A	139358996	3	1	109	1	0	0	0	0	1	0	0	0	13986	942	33	1	2847	1	SEC16A	9	139358996	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3580821	139358996	1854435	166	33337										
C9orf172	389813	broad.mit.edu	37	chr9	139739870	139739870	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggagaggtgcgcaccttccCaatccaggaaccgccctccc	10	17	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:139739870C>T	uc011meh.1	+	1	1004	c.1004C>T	c.(1003-1005)CCA>CTA	p.P335L	PHPT1_uc004cjp.2_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	335	Pro-rich.										0						CGCACCTTCCCAATCCAGGAA	0.692													0	0	0	0.021553	0	6	22										T	139739870	C	T	139739870	3	4	109	1	0	0	0	0	1	0	0	0	2471	594	21	2	1006	2	C9orf172	9	139739870	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	380874	139739870	1473561	167	33338										
C9orf172	389813	broad.mit.edu	37	chr9	139741083	139741083	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	caccgcgctttctcgcgcatCgcgcgtgtcggcttcctgtc	11	17	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:139741083C>G	uc011meh.1	+	1	2217	c.2217C>G	c.(2215-2217)ATC>ATG	p.I739M	PHPT1_uc004cjp.2_5'Flank|PHPT1_uc011mei.1_5'Flank|PHPT1_uc004cjq.3_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	739											0						TCTCGCGCATCGCGCGTGTCG	0.706													0	0	0	0.021553	0	6	11										G	139741083	C	G	139741083	3	3	109	1	0	0	0	0	1	0	0	0	2471	874	31	1	2219	1	C9orf172	9	139741083	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1213	139741083	1472348	168	33339										
NRARP	441478	broad.mit.edu	37	chr9	140196037	140196037	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tccggggtcccggcgggcatCaccggccgctggccgcgtac	16	17	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr9:140196037C>T	uc004cmo.2	-	1	667	c.344G>A	c.(343-345)TGA>TAA	p.*115*	C9orf167_uc011mew.1_Intron	NM_001004354	NP_001004354	Q7Z6K4	NRARP_HUMAN	NOTCH-regulated ankyrin repeat protein	115					negative regulation of Notch signaling pathway|positive regulation of canonical Wnt receptor signaling pathway						0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.185)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000273)		CGGCGGGCATCACCGGCCGCT	0.731													0	0	0	0.009096	0	4	6										T	140196037	C	T	140196037	2	4	109	1	0	0	0	0	0	0	0	1	10639	837	29	1		1	NRARP	9	140196037	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	454954	140196037	1017394	169	33340										
CELF2	10659	broad.mit.edu	37	chr10	11207533	11207533	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	attaagatgtttgtcggacaGatcccccggtcatggtcgga	12	9	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:11207533G>A	uc001iki.3	+	2	230	c.138G>A	c.(136-138)CAG>CAA	p.Q46Q	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Silent_p.Q46Q|CELF2_uc001ikk.2_Silent_p.Q53Q|CELF2_uc001ikl.3_Silent_p.Q53Q|CELF2_uc010qbk.1_RNA|CELF2_uc010qbl.1_Silent_p.Q22Q|CELF2_uc010qbm.1_5'UTR|CELF2_uc001iko.3_Silent_p.Q22Q|CELF2_uc001ikp.3_Silent_p.Q22Q|CELF2_uc010qbn.1_Silent_p.Q30Q|CELF2_uc009xiw.1_Silent_p.Q22Q|CELF2_uc010qbo.1_5'UTR|CELF2_uc010qbp.1_5'UTR	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	46	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 1.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						TTGTCGGACAGATCCCCCGGT	0.522													0	0	0	0.099896	0	27	91										A	11207533	G	A	11207533	2	1	109	1	0	0	0	0	0	0	0	1	3216	933	33	1		1	CELF2	10	11207533	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		11207533	124327214	170	33341										
PDSS1	23590	broad.mit.edu	37	chr10	26998684	26998684	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccgagcatgcaatattcatCataacaactcccggtgagct	7	13	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:26998684C>T	uc001isv.2	+	5	500	c.454C>T	c.(454-456)CAT>TAT	p.H152Y	PDSS1_uc001isw.2_Missense_Mutation_p.H152Y	NM_014317	NP_055132	Q5T2R2	DPS1_HUMAN	prenyl diphosphate synthase, subunit 1	152					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity				0						CAATATTCATCATAACAACTC	0.393													0	0	0	0.134883	0	27	112										T	26998684	C	T	26998684	3	4	109	1	0	0	0	0	1	0	0	0	11693	826	29	1	472	1	PDSS1	10	26998684	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	15791151	26998684	108536063	171	33342										
ANKRD30A	91074	broad.mit.edu	37	chr10	37506789	37506789	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atatagaattgaagagtgtaGaaagtaatttgaatcaggta	10	1	1	5			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:37506789G>C	uc001iza.1	+	33	3181	c.3082G>C	c.(3082-3084)GAA>CAA	p.E1028Q		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1084	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GAAGAGTGTAGAAAGTAATTT	0.284													0	0	0	0.047766	0	8	30										C	37506789	G	C	37506789	3	2	109	1	0	0	0	0	1	0	0	0	658	943	33	1	3212	1	ANKRD30A	10	37506789	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	10508105	37506789	98027958	172	33343										
OGDHL	55753	broad.mit.edu	37	chr10	50947854	50947854	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcccagaggaccagggcattGgggctggccatggcatagcc	15	12	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:50947854G>T	uc001jie.2	-	17	2314	c.2172C>A	c.(2170-2172)CCC>CCA	p.P724P	OGDHL_uc009xog.2_Silent_p.P751P|OGDHL_uc010qgt.1_Silent_p.P667P|OGDHL_uc010qgu.1_Silent_p.P515P	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	724					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CCAGGGCATTGGGGCTGGCCA	0.572													1	0	4.3838e-07	0.105934	5.05735e-07	14	27										T	50947854	G	T	50947854	2	4	109	1	0	0	0	0	0	0	0	1	10840	1335	47	4		4	OGDHL	10	50947854	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	13441065	50947854	84586893	173	33344										
CTNNA3	29119	broad.mit.edu	37	chr10	69281696	69281696	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatttgttggcaacatttttGagagactcaaatgtcctttg	9	6	1	2	rs74142830	byFrequency	TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:69281696G>C	uc009xpn.1	-	5	606	c.483C>G	c.(481-483)CTC>CTG	p.L161L	CTNNA3_uc001jmw.2_Silent_p.L161L|CTNNA3_uc001jmx.3_Silent_p.L161L|CTNNA3_uc009xpo.1_Silent_p.L21L|CTNNA3_uc001jna.2_Silent_p.L173L	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	161					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CAACATTTTTGAGAGACTCAA	0.383													0	0	0	0.115264	0	3	76										C	69281696	G	C	69281696	2	2	109	1	0	0	0	0	0	0	0	1	4014	1277	45	1		1	CTNNA3	10	69281696	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	18333842	69281696	66253051	174	33345										
HK1	3098	broad.mit.edu	37	chr10	71144659	71144659	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcatttccctgccagcagacGagtctggacgcggtgagtct	12	12	3	2	rs148999865		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:71144659G>A	uc001jpl.3	+	12	1928	c.1827G>A	c.(1825-1827)ACG>ACA	p.T609T	HK1_uc001jpg.3_Silent_p.T597T|HK1_uc001jph.3_Silent_p.T613T|HK1_uc001jpi.3_Silent_p.T613T|HK1_uc001jpj.3_Silent_p.T644T|HK1_uc001jpk.3_Silent_p.T608T|HK1_uc009xqd.2_Silent_p.T487T	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	609	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GCCAGCAGACGAGTCTGGACG	0.587													0	0	0	0.047766	0	9	173										A	71144659	G	A	71144659	2	1	109	1	0	0	0	0	0	0	0	1	7190	1045	37	1		1	HK1	10	71144659	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1862963	71144659	64390088	175	33346										
DNAJB12	54788	broad.mit.edu	37	chr10	74100797	74100797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaggtcttcaggggagatgtCggcctcaaagccacggtgga	16	9	3	1	rs147227290		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:74100797C>T	uc010qjv.1	-	4	841	c.691G>A	c.(691-693)GAC>AAC	p.D231N	DNAJB12_uc001jsz.2_Missense_Mutation_p.D231N|DNAJB12_uc001jta.2_Missense_Mutation_p.D231N	NM_017626	NP_060096	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	197					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding				0						GGGGAGATGTCGGCCTCAAAG	0.607													0	0	0	0.047766	0	9	36										T	74100797	C	T	74100797	3	4	109	1	0	0	0	0	1	0	0	0	4617	884	31	1	558	1	DNAJB12	10	74100797	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2956138	74100797	61433950	176	33347										
USP54	159195	broad.mit.edu	37	chr10	75301468	75301468	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcttggtgaaggtttctctcGtctttccagcatacaaatag	9	9	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:75301468G>A	uc001juo.2	-	6	618	c.601C>T	c.(601-603)CGA>TGA	p.R201*	USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Nonsense_Mutation_p.R201*|USP54_uc010qkl.1_Nonsense_Mutation_p.R201*|USP54_uc001juq.1_Translation_Start_Site	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	201					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					GGTTTCTCTCGTCTTTCCAGC	0.453													0	0	0	0.0333	0	16	53										A	75301468	G	A	75301468	4	1	109	1	0	0	0	0	0	1	0	0	17082	1153	40	2	4521	2	USP54	10	75301468	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1200671	75301468	60233279	177	33348										
COMTD1	118881	broad.mit.edu	37	chr10	76993969	76993969	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttcggaggttgcagcaccttCccgcgccacaggacctgcgg	13	15	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:76993969C>T	uc001jxb.2	-	7	735	c.651G>A	c.(649-651)GGG>GGA	p.G217G	COMTD1_uc001jxc.1_Missense_Mutation_p.E309K	NM_144589	NP_653190	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing	217						integral to membrane	O-methyltransferase activity				0	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					GCAGCACCTTCCCGCGCCACA	0.706													0	0	0	0.021553	0	5	46										T	76993969	C	T	76993969	2	4	109	1	0	0	0	0	0	0	0	1	3726	842	30	1		1	COMTD1	10	76993969	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1692501	76993969	58540778	178	33349										
PLCE1	51196	broad.mit.edu	37	chr10	96018855	96018855	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggctccgagtcagccccactCtacaccaacctgacaattga	7	16	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:96018855C>G	uc001kjk.2	+	13	4396	c.3762C>G	c.(3760-3762)CTC>CTG	p.L1254L	PLCE1_uc010qnx.1_Silent_p.L1238L|PLCE1_uc001kjm.2_Silent_p.L946L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1254					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				CAGCCCCACTCTACACCAACC	0.478													0	0	0	0.09836	0	36	132										G	96018855	C	G	96018855	2	3	109	1	0	0	0	0	0	0	0	1	12034	900	32	1		1	PLCE1	10	96018855	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	19024886	96018855	39515892	179	33350										
DNTT	1791	broad.mit.edu	37	chr10	98064410	98064410	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	accacccgcagagcgttcctCatggagctggcccgcaggaa	12	15	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:98064410C>T	uc001kmf.2	+	1	326	c.156C>T	c.(154-156)CTC>CTT	p.L52L	DNTT_uc001kmg.2_Silent_p.L52L	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	52	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		GAGCGTTCCTCATGGAGCTGG	0.493													0	0	0	0.047766	0	8	35										T	98064410	C	T	98064410	2	4	109	1	0	0	0	0	0	0	0	1	4680	813	29	1		1	DNTT	10	98064410	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2045555	98064410	37470337	180	33351										
SEMA4G	57715	broad.mit.edu	37	chr10	102738085	102738085	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcaccttgccaaccagcttcGaggaggggaaggagaagtgt	14	9	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:102738085G>C	uc010qpt.1	+	6	912	c.469G>C	c.(469-471)GAG>CAG	p.E157Q	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krw.1_Missense_Mutation_p.E157Q|SEMA4G_uc001krx.2_Missense_Mutation_p.E157Q|MRPL43_uc001kry.1_3'UTR|MRPL43_uc010qpu.1_3'UTR	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	157	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		AACCAGCTTCGAGGAGGGGAA	0.532													0	0	0	0.021553	0	6	20										C	102738085	G	C	102738085	3	2	109	1	0	0	0	0	1	0	0	0	14036	1059	37	1	487	1	SEMA4G	10	102738085	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	4673675	102738085	32796662	181	33352										
CALHM2	51063	broad.mit.edu	37	chr10	105209459	105209459	+	Frame_Shift_Del	DEL	C	C	-													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggcactcggccacgaggttCcaggtgtggttgttgaggat							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:105209459delC	uc001kwz.2	-	2	626	c.240delG	c.(238-240)TGGfs	p.W80fs	CALHM2_uc001kxa.2_Frame_Shift_Del_p.W80fs|CALHM2_uc001kxc.2_Frame_Shift_Del_p.W80fs|CALHM2_uc001kxb.2_Frame_Shift_Del_p.W80fs|CALHM2_uc001kxd.1_Frame_Shift_Del_p.W80fs	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	80						integral to membrane				skin(1)	1						CCACGAGGTTCCAGGTGTGGT	0.662																		28	104	---	---								-	105209459	C	-	105209459	7	5	109	1	0	1	0	1	0	0	0	0	2583	856	30	0	739	0	CALHM2	10	105209459	Frame_Shift_Del	DEL	C	TCGA-GD-A2C5-01A-12D-A17V-08	2471374	105209459	30325288	182	33353										
PDCD4	27250	broad.mit.edu	37	chr10	112641289	112641289	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aaaggaaggggactaccaaaGaaaggttggtatatatcatg	12	4	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:112641289G>C	uc001kzh.2	+	3	585	c.342G>C	c.(340-342)AAG>AAC	p.K114N	PDCD4_uc001kzg.2_Missense_Mutation_p.K103N|PDCD4_uc010qre.1_Missense_Mutation_p.K100N	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	114					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GACTACCAAAGAAAGGTTGGT	0.433													0	0	0	0.049695	0	19	91										C	112641289	G	C	112641289	3	2	109	1	0	0	0	0	1	0	0	0	11621	933	33	1	362	1	PDCD4	10	112641289	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	7431830	112641289	22893458	183	33354										
MKI67	4288	broad.mit.edu	37	chr10	129904961	129904961	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acttggtgtctggaagagctCgatgaagccggccaggtctt	14	9	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:129904961C>T	uc001lke.2	-	13	5338	c.5143G>A	c.(5143-5145)GAG>AAG	p.E1715K	MKI67_uc001lkf.2_Missense_Mutation_p.E1355K|MKI67_uc009yav.1_Missense_Mutation_p.E1290K|MKI67_uc009yaw.1_Missense_Mutation_p.E865K	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1715	6.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGGAAGAGCTCGATGAAGCCG	0.498													0	0	0	0.0333	0	15	58										T	129904961	C	T	129904961	3	4	109	1	0	0	0	0	1	0	0	0	9598	893	31	1	4639	1	MKI67	10	129904961	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	17263672	129904961	5629786	184	33355										
MKI67	4288	broad.mit.edu	37	chr10	129904991	129904991	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggccaggtcttcagggacttCagactttcccttaggagttc	11	11	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:129904991C>T	uc001lke.2	-	13	5308	c.5113G>A	c.(5113-5115)GAA>AAA	p.E1705K	MKI67_uc001lkf.2_Missense_Mutation_p.E1345K|MKI67_uc009yav.1_Missense_Mutation_p.E1280K|MKI67_uc009yaw.1_Missense_Mutation_p.E855K	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1705	6.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCAGGGACTTCAGACTTTCCC	0.468													0	0	0	0.11911	0	14	64										T	129904991	C	T	129904991	3	4	109	1	0	0	0	0	1	0	0	0	9598	835	29	1	4669	1	MKI67	10	129904991	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	30	129904991	5629756	185	33356										
C10orf93	255352	broad.mit.edu	37	chr10	134752189	134752189	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggatcagatggtgacgatatCcaggcttgaggaacggcctc	14	9	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr10:134752189C>G	uc001llt.1	-	5	516	c.440G>C	c.(439-441)GGA>GCA	p.G147A	C10orf93_uc001llu.2_Missense_Mutation_p.G147A	NM_173572	NP_775843	Q5SR76	CJ093_HUMAN	hypothetical protein LOC255352	147							binding			pancreas(1)	1		all_cancers(35;1.8e-07)|all_epithelial(44;6.22e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Colorectal(31;0.119)|Glioma(114;0.172)|Melanoma(40;0.175)		Epithelial(32;4.28e-05)|OV - Ovarian serous cystadenocarcinoma(35;4.31e-05)|all cancers(32;5.02e-05)		GTGACGATATCCAGGCTTGAG	0.537													0	0	0	0.043863	0	18	100										G	134752189	C	G	134752189	3	3	109	1	0	0	0	0	1	0	0	0	1625	855	30	1	797	1	C10orf93	10	134752189	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4847198	134752189	782558	186	33357										
TRIM5	85363	broad.mit.edu	37	chr11	5687293	5687293	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggaaaagtttctggcttcttCaaggtcacgttctccgtcct	9	11	5	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:5687293C>G	uc001mbm.1	-	6	1043	c.786G>C	c.(784-786)TTG>TTC	p.L262F	TRIM78P_uc009yer.2_RNA|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Missense_Mutation_p.L262F|TRIM5_uc001mbo.2_Missense_Mutation_p.L262F|TRIM5_uc001mbp.2_Missense_Mutation_p.L262F	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	262					interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		CTGGCTTCTTCAAGGTCACGT	0.398													0	0	0	0.132662	0	15	41										G	5687293	C	G	5687293	3	3	109	1	0	0	0	0	1	0	0	0	16522	825	29	1	946	1	TRIM5	11	5687293	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		5687293	129319223	187	33358										
CCKBR	887	broad.mit.edu	37	chr11	6292495	6292495	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tttatagtgccaacacgtggCgcgcctttgatggcccgggt	13	11	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:6292495C>T	uc001mcp.2	+	5	1259	c.1066C>T	c.(1066-1068)CGC>TGC	p.R356C	CCKBR_uc001mcq.2_Missense_Mutation_p.R284C|CCKBR_uc001mcr.2_Missense_Mutation_p.R356C|CCKBR_uc001mcs.2_Missense_Mutation_p.R425C|CCKBR_uc001mct.1_RNA	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	356	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	CAACACGTGGCGCGCCTTTGA	0.567													0	0	0	0.146539	0	16	58										T	6292495	C	T	6292495	3	4	109	1	0	0	0	0	1	0	0	0	2881	768	27	2	1084	2	CCKBR	11	6292495	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	605202	6292495	128714021	188	33359										
MICAL2	9645	broad.mit.edu	37	chr11	12248632	12248632	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttggccaaatcatccatttCtaataactatctcaacctca	2	13	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:12248632C>G	uc001mjz.2	+	15	2237	c.1949C>G	c.(1948-1950)TCT>TGT	p.S650C	MICAL2_uc010rch.1_Missense_Mutation_p.S650C|MICAL2_uc001mka.2_Missense_Mutation_p.S650C|MICAL2_uc010rci.1_Missense_Mutation_p.S650C|MICAL2_uc001mkb.2_Missense_Mutation_p.S650C|MICAL2_uc001mkc.2_Missense_Mutation_p.S650C|MICAL2_uc001mkd.2_Missense_Mutation_p.S479C|MICAL2_uc010rcj.1_Missense_Mutation_p.S52C	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	650						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		TCATCCATTTCTAATAACTAT	0.448													0	0	0	0.047766	0	5	27										G	12248632	C	G	12248632	3	3	109	1	0	0	0	0	1	0	0	0	9570	913	32	1	1999	1	MICAL2	11	12248632	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	5956137	12248632	122757884	189	33360										
C11orf41	25758	broad.mit.edu	37	chr11	33631370	33631370	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcctcaaagccaagaggaagGgatattacgacttccctgca	10	11	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:33631370G>T	uc001mup.3	+	14	4388	c.4264G>T	c.(4264-4266)GGA>TGA	p.G1422*		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1416						integral to membrane				ovary(2)	2						CAAGAGGAAGGGATATTACGA	0.517													1	0	2.17888e-05	0.058154	2.49417e-05	9	18										T	33631370	G	T	33631370	4	4	109	1	0	0	0	0	0	1	0	0	1640	1233	43	4	4318	4	C11orf41	11	33631370	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	21382738	33631370	101375146	190	33361										
CHST1	8534	broad.mit.edu	37	chr11	45671793	45671793	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cggaccagctggatgaccttGaggtttaatcgcgggtcttc	13	10	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:45671793G>C	uc001mys.1	-	4	1352	c.681C>G	c.(679-681)CTC>CTG	p.L227L		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	227	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		GGATGACCTTGAGGTTTAATC	0.687													0	0	0	0.043863	0	19	26										C	45671793	G	C	45671793	2	2	109	1	0	0	0	0	0	0	0	1	3397	1277	45	1		1	CHST1	11	45671793	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	12040423	45671793	89334723	191	33362										
OR4X2	119764	broad.mit.edu	37	chr11	48267481	48267481	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgataaccgcgatcctgaacCctgtcatctactctctgaga	7	13	3	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:48267481C>T	uc001ngs.1	+	1	826	c.826C>T	c.(826-828)CCT>TCT	p.P276S		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATCCTGAACCCTGTCATCTA	0.483													0	0	0	0.0333	0	16	28										T	48267481	C	T	48267481	3	4	109	1	0	0	0	0	1	0	0	0	11085	623	22	2	828	2	OR4X2	11	48267481	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2595688	48267481	86739035	192	33363										
OR4S1	256148	broad.mit.edu	37	chr11	48328337	48328337	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cctgctcaagttggcctgtgCagacacctacatggtaggtc	11	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:48328337C>T	uc010rhu.1	+	1	563	c.563C>T	c.(562-564)GCA>GTA	p.A188V		NM_001004725	NP_001004725	Q8NGB4	OR4S1_HUMAN	olfactory receptor, family 4, subfamily S,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTGGCCTGTGCAGACACCTAC	0.463													0	0	0	0.045705	0	32	23										T	48328337	C	T	48328337	3	4	109	1	0	0	0	0	1	0	0	0	11082	710	25	2	565	2	OR4S1	11	48328337	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	60856	48328337	86678179	193	33364										
SERPING1	710	broad.mit.edu	37	chr11	57379282	57379282	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaagacatggaacaggctctCagcccttctgttttcaaggc	10	11	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:57379282C>T	uc001nkp.1	+	7	1313	c.1122C>T	c.(1120-1122)CTC>CTT	p.L374L	SERPING1_uc001nkq.1_Intron|SERPING1_uc010rju.1_Silent_p.L322L|SERPING1_uc010rjv.1_Silent_p.L379L|SERPING1_uc001nkr.1_Silent_p.L374L|SERPING1_uc009ymi.1_Silent_p.L383L|SERPING1_uc009ymj.1_Intron|SERPING1_uc001nks.1_Silent_p.L65L	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	374				MEQALS -> TGTGSQ (in Ref. 19; AA sequence).	blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						AACAGGCTCTCAGCCCTTCTG	0.522									Hereditary_Angioedema				0	0	0	0.139131	0	78	121										T	57379282	C	T	57379282	2	4	109	1	0	0	0	0	0	0	0	1	14116	813	29	1		1	SERPING1	11	57379282	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	9050945	57379282	77627234	194	33365										
STIP1	10963	broad.mit.edu	37	chr11	63971071	63971071	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttatcctggaacagatgcaGaaggacccccaggcactcag	10	13	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:63971071G>A	uc001nyk.1	+	13	1683	c.1536G>A	c.(1534-1536)CAG>CAA	p.Q512Q	STIP1_uc010rnb.1_Silent_p.Q488Q	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	512	STI1 2.				axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3						AACAGATGCAGAAGGACCCCC	0.597													0	0	0	0.069234	0	10	43										A	63971071	G	A	63971071	2	1	109	1	0	0	0	0	0	0	0	1	15284	933	33	1		1	STIP1	11	63971071	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6591789	63971071	71035445	195	33366										
KAT5	10524	broad.mit.edu	37	chr11	65481068	65481068	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggtttctctctgcagaaacGgaaggtggaggtggtttcac	14	7	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:65481068G>A	uc001ofi.2	+	6	696	c.446G>A	c.(445-447)CGG>CAG	p.R149Q	KAT5_uc001ofj.2_Missense_Mutation_p.R97Q|KAT5_uc001ofk.2_Missense_Mutation_p.R182Q|KAT5_uc010roo.1_Missense_Mutation_p.R130Q|KAT5_uc001ofl.2_5'UTR	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	149					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						CTGCAGAAACGGAAGGTGGAG	0.547													0	0	0	0.076483	0	24	81										A	65481068	G	A	65481068	3	1	109	1	0	0	0	0	1	0	0	0	7983	1116	39	2	563	2	KAT5	11	65481068	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1509997	65481068	69525448	196	33367										
CD248	57124	broad.mit.edu	37	chr11	66083095	66083095	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gctgggtgtgtggcagggatCacaggaggctggtgggcaga	21	6	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:66083095C>T	uc001ohm.1	-	1	1421	c.1404G>A	c.(1402-1404)GTG>GTA	p.V468V		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	468	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	TGGCAGGGATCACAGGAGGCT	0.622													0	0	0	0.080422	0	34	125										T	66083095	C	T	66083095	2	4	109	1	0	0	0	0	0	0	0	1	2989	813	29	1		1	CD248	11	66083095	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	602027	66083095	68923421	197	33368										
SPTBN2	6712	broad.mit.edu	37	chr11	66473242	66473242	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatgtctgcctccaccagctCgtgcagctgcagcaggtcct	11	15	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:66473242C>T	uc001ojd.2	-	13	1792	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	574	Spectrin 3.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						TCCACCAGCTCGTGCAGCTGC	0.667													0	0	0	0.069234	0	11	29										T	66473242	C	T	66473242	3	4	109	1	0	0	0	0	1	0	0	0	15119	893	31	1	5552	1	SPTBN2	11	66473242	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	390147	66473242	68533274	198	33369										
PPFIA1	8500	broad.mit.edu	37	chr11	70194497	70194497	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tccctcacagcccagctcggGaagtggacagactgggcgtc	13	14	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:70194497G>T	uc001opo.2	+	16	2332	c.2134G>T	c.(2134-2136)GAA>TAA	p.E712*	PPFIA1_uc001opn.1_Nonsense_Mutation_p.E712*|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	712					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CCCAGCTCGGGAAGTGGACAG	0.602													1	0	2.73361e-28	0.139131	3.26413e-28	64	163										T	70194497	G	T	70194497	4	4	109	1	0	0	0	0	0	1	0	0	12309	1175	41	3	2192	3	PPFIA1	11	70194497	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3721255	70194497	64812019	199	33370										
INTS4	92105	broad.mit.edu	37	chr11	77629999	77629999	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgatgctgggagaaacagctGatgacaccagttttctacct	10	9	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:77629999G>C	uc001oys.2	-	15	1818	c.1790C>G	c.(1789-1791)TCA>TGA	p.S597*	INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	597					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AGAAACAGCTGATGACACCAG	0.458													0	0	0	0.099896	0	24	158										C	77629999	G	C	77629999	4	2	109	1	0	0	0	0	0	1	0	0	7780	1294	45	1	1137	1	INTS4	11	77629999	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	7435502	77629999	57376517	200	33371										
MTMR2	8898	broad.mit.edu	37	chr11	95591730	95591730	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aggaaatgcatatttcattaGattctcaaatatggatcttc	6	6	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr11:95591730G>C	uc001pfu.2	-	6	788	c.535C>G	c.(535-537)CTA>GTA	p.L179V	MTMR2_uc001pfv.2_Missense_Mutation_p.L107V|MTMR2_uc001pfs.2_Missense_Mutation_p.L107V|MTMR2_uc001pft.2_Missense_Mutation_p.L107V|MTMR2_uc010ruj.1_Missense_Mutation_p.L162V	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	179						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TATTTCATTAGATTCTCAAAT	0.318													0	0	0	0.139131	0	40	160										C	95591730	G	C	95591730	3	2	109	1	0	0	0	0	1	0	0	0	9944	933	33	1	1436	1	MTMR2	11	95591730	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	17961731	95591730	39414786	201	33372										
PHB2	11331	broad.mit.edu	37	chr12	7076925	7076925	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttctaccaagaattgggcccGctgggcctcctgctgggctg	13	13	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:7076925G>A	uc001qsd.2	-	6	835	c.625C>T	c.(625-627)CGG>TGG	p.R209W	PHB2_uc010sft.1_Intron|PHB2_uc010sfu.1_3'UTR|PHB2_uc001qse.1_5'Flank|PHB2_uc001qsf.1_5'Flank|PHB2_uc009zfn.1_5'Flank|SCARNA12_uc001qsg.2_5'Flank	NM_001144831	NP_001138303	Q99623	PHB2_HUMAN	prohibitin 2 isoform 1	209	Potential.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						AATTGGGCCCGCTGGGCCTCC	0.587													0	0	0	0.139131	0	53	193										A	7076925	G	A	7076925	3	1	109	1	0	0	0	0	1	0	0	0	11815	1086	38	2	290	2	PHB2	12	7076925	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		7076925	126774970	202	33373										
GDF3	9573	broad.mit.edu	37	chr12	7842947	7842947	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cacccctgagtctctatcttCtttgaccagtatctccagga	6	14	4	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:7842947C>G	uc001qte.2	-	2	658	c.622G>C	c.(622-624)GAA>CAA	p.E208Q		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	208					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						TCTCTATCTTCTTTGACCAGT	0.493													0	0	0	0.062417	0	23	49										G	7842947	C	G	7842947	3	3	109	1	0	0	0	0	1	0	0	0	6315	922	32	1	476	1	GDF3	12	7842947	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	766022	7842947	126008948	203	33374										
FOXJ2	55810	broad.mit.edu	37	chr12	8205417	8205417	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtgccaatgaggagatccctGatgacttcgactgggacttg	13	9	0	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:8205417G>C	uc001qtu.2	+	11	2781	c.1696G>C	c.(1696-1698)GAT>CAT	p.D566H		NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	566					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)		GGAGATCCCTGATGACTTCGA	0.532													0	0	0	0.009096	0	4	11										C	8205417	G	C	8205417	3	2	109	1	0	0	0	0	1	0	0	0	6012	1290	45	1	1734	1	FOXJ2	12	8205417	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	362470	8205417	125646478	204	33375										
KIAA1467	57613	broad.mit.edu	37	chr12	13208508	13208508	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agaagagcccagacctagggGagtatgatccacttacccag	11	11	0	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:13208508G>A	uc001rbi.2	+	2	84	c.61G>A	c.(61-63)GAG>AAG	p.E21K	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	21						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		AGACCTAGGGGAGTATGATCC	0.473													0	0	0	0.0333	0	16	45										A	13208508	G	A	13208508	3	1	109	1	0	0	0	0	1	0	0	0	8235	1175	41	1	67	1	KIAA1467	12	13208508	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	5003091	13208508	120643387	205	33376										
RERG	85004	broad.mit.edu	37	chr12	15262116	15262116	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtggagctgcgtcgcctcgtCttgccctgcaccatcctccg	11	17	1	0	rs147938337	byFrequency	TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:15262116C>T	uc001rcs.2	-	4	668	c.528G>A	c.(526-528)AAG>AAA	p.K176K	RERG_uc001rct.2_Silent_p.K176K|RERG_uc010shu.1_Silent_p.K157K	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	176					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						GTCGCCTCGTCTTGCCCTGCA	0.522													0	0	0	0.069456	0	37	86										T	15262116	C	T	15262116	2	4	109	1	0	0	0	0	0	0	0	1	13232	912	32	1		1	RERG	12	15262116	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2053608	15262116	118589779	206	33377										
PTPRO	5800	broad.mit.edu	37	chr12	15733754	15733754	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcatgctcactcagtgtaatGagaaaaggagggtacgtact	11	7	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:15733754G>C	uc001rcv.1	+	22	3295	c.3121G>C	c.(3121-3123)GAG>CAG	p.E1041Q	PTPRO_uc001rcw.1_Missense_Mutation_p.E1013Q|PTPRO_uc001rcx.1_Missense_Mutation_p.E230Q|PTPRO_uc001rcy.1_Missense_Mutation_p.E230Q|PTPRO_uc001rcz.1_Missense_Mutation_p.E202Q|PTPRO_uc001rda.1_Missense_Mutation_p.E202Q	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1041	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				TCAGTGTAATGAGAAAAGGAG	0.448													0	0	0	0.11911	0	13	54										C	15733754	G	C	15733754	3	2	109	1	0	0	0	0	1	0	0	0	12809	1291	45	1	3207	1	PTPRO	12	15733754	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	471638	15733754	118118141	207	33378										
SLCO1B1	10599	broad.mit.edu	37	chr12	21358897	21358897	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atgggaaccagtctgtggaaAcaatggaataacttacatct	9	7	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:21358897A>G	uc001req.3	+	11	1531	c.1427A>G	c.(1426-1428)AAC>AGC	p.N476S		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	476	Extracellular (Potential).|Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GTCTGTGGAAACAATGGAATA	0.383													0	0	0	0.11911	0	15	49										G	21358897	A	G	21358897	3	3	109	1	0	0	0	0	1	0	0	0	14723	43	2	5	1465	5	SLCO1B1	12	21358897	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	5625143	21358897	112492998	208	33379										
CNTN1	1272	broad.mit.edu	37	chr12	41337481	41337481	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tctatacatgctttgcagaaAataacagagggaaagctaat	8	6	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:41337481A>T	uc001rmm.1	+	13	1575	c.1462A>T	c.(1462-1464)AAT>TAT	p.N488Y	CNTN1_uc009zjy.1_Missense_Mutation_p.N488Y|CNTN1_uc001rmn.1_Missense_Mutation_p.N477Y|CNTN1_uc001rmo.2_Missense_Mutation_p.N488Y	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	488	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CTTTGCAGAAAATAACAGAGG	0.333													0	0	0	0.02938	0	6	30										T	41337481	A	T	41337481	3	4	109	1	0	0	0	0	1	0	0	0	3640	14	1	5	1508	5	CNTN1	12	41337481	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	19978584	41337481	92514414	209	33380										
SLC38A1	81539	broad.mit.edu	37	chr12	46598164	46598164	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tattgttgaatttagctctgGaacaatgcagggaatttgaa	10	4	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:46598164G>C	uc001rpa.2	-	11	1000	c.742C>G	c.(742-744)CCA>GCA	p.P248A	SLC38A1_uc001rpb.2_Missense_Mutation_p.P248A|SLC38A1_uc001rpc.2_Missense_Mutation_p.P248A|SLC38A1_uc001rpd.2_Missense_Mutation_p.P248A|SLC38A1_uc001rpe.2_Missense_Mutation_p.P248A|SLC38A1_uc010slh.1_Missense_Mutation_p.P221A|SLC38A1_uc009zkj.1_Missense_Mutation_p.P248A	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	248	Extracellular (Potential).				cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			TTTAGCTCTGGAACAATGCAG	0.323													0	0	0	0.116897	0	29	140										C	46598164	G	C	46598164	3	2	109	1	0	0	0	0	1	0	0	0	14601	1174	41	1	749	1	SLC38A1	12	46598164	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	5260683	46598164	87253731	210	33381										
VDR	7421	broad.mit.edu	37	chr12	48240460	48240460	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctttggtcacgtcactgacgCggtacttgtagtcttggttg	12	9	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:48240460C>T	uc001rqm.2	-	9	1169	c.887G>A	c.(886-888)CGC>CAC	p.R296H	VDR_uc001rql.2_Missense_Mutation_p.R346H|VDR_uc001rqn.2_Missense_Mutation_p.R296H|VDR_uc010slq.1_Missense_Mutation_p.R264H	NM_001017535	NP_001017535	P11473	VDR_HUMAN	vitamin D (1,25-dihydroxyvitamin D3) receptor	296	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GTCACTGACGCGGTACTTGTA	0.542													0	0	0	0.108266	0	28	33										T	48240460	C	T	48240460	3	4	109	1	0	0	0	0	1	0	0	0	17146	768	27	2	408	2	VDR	12	48240460	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1642296	48240460	85611435	211	33382										
MLL2	8085	broad.mit.edu	37	chr12	49434818	49434818	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agcgaggggcagcggggtttGaggaatgggtcaggtgtgga	22	4	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:49434818G>C	uc001rta.3	-	31	6735	c.6735C>G	c.(6733-6735)CTC>CTG	p.L2245L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2245	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGCGGGGTTTGAGGAATGGGT	0.657			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.043863	0	18	52										C	49434818	G	C	49434818	2	2	109	1	0	0	0	0	0	0	0	1	9621	1277	45	1		1	MLL2	12	49434818	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1194358	49434818	84417077	212	33383										
KRT6B	3854	broad.mit.edu	37	chr12	52845415	52845415	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatggcggggtcaatttgcaGgttgaggggagtcaggagac	19	5	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:52845415G>C	uc001sak.2	-	1	496	c.448C>G	c.(448-450)CTG>GTG	p.L150V		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	150	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		TCAATTTGCAGGTTGAGGGGA	0.612													0	0	0	0.049695	0	17	122										C	52845415	G	C	52845415	3	2	109	1	0	0	0	0	1	0	0	0	8481	991	35	4	1282	4	KRT6B	12	52845415	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3410597	52845415	81006480	213	33384										
KRT73	319101	broad.mit.edu	37	chr12	53004528	53004528	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccttggcctgctgcagggcgCcctccagctcatccagcttg	11	17	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:53004528C>T	uc001sas.2	-	7	1237	c.1202G>A	c.(1201-1203)GGC>GAC	p.G401D		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	401	Rod.|Coil 2.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTGCAGGGCGCCCTCCAGCTC	0.637													0	0	0	0.11911	0	13	69										T	53004528	C	T	53004528	3	4	109	1	0	0	0	0	1	0	0	0	8486	739	26	2	432	2	KRT73	12	53004528	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	159113	53004528	80847367	214	33385										
ITGA5	3678	broad.mit.edu	37	chr12	54799103	54799103	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cctgcccacctcctgaggccGcccgtcaggggtccgatcca	11	19	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:54799103G>A	uc001sga.2	-	12	1140	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	358	Extracellular (Potential).|FG-GAP 5.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						TCCTGAGGCCGCCCGTCAGGG	0.647													0	0	0	0.021553	0	6	26										A	54799103	G	A	54799103	3	1	109	1	0	0	0	0	1	0	0	0	7879	1086	38	2	2153	2	ITGA5	12	54799103	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1794575	54799103	79052792	215	33386										
OR6C65	403282	broad.mit.edu	37	chr12	55794819	55794819	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	caactggatttttgtgactcCagcactattgaccatttcat	6	10	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:55794819C>A	uc010spl.1	+	1	507	c.507C>A	c.(505-507)TCC>TCA	p.S169S		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTTGTGACTCCAGCACTATTG	0.438													1	0	8.06951e-73	0.139131	9.7672e-73	145	195										A	55794819	C	A	55794819	2	1	109	1	0	0	0	0	0	0	0	1	11195	581	21	4		4	OR6C65	12	55794819	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	995716	55794819	78057076	216	33387										
BAZ2A	11176	broad.mit.edu	37	chr12	56998908	56998908	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtgcagccttcagcagcctGaccagcaggtcttgcacctc	10	15	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:56998908G>A	uc001slq.1	-	14	2897	c.2703C>T	c.(2701-2703)GTC>GTT	p.V901V	BAZ2A_uc001slp.1_Silent_p.V899V|BAZ2A_uc001slo.1_5'Flank|BAZ2A_uc009zov.1_5'Flank|BAZ2A_uc009zow.1_Silent_p.V869V	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	901	DDT.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TCAGCAGCCTGACCAGCAGGT	0.557													0	0	0	0.058154	0	9	55										A	56998908	G	A	56998908	2	1	109	1	0	0	0	0	0	0	0	1	1331	1277	45	1		1	BAZ2A	12	56998908	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1204089	56998908	76852987	217	33388										
BEST3	144453	broad.mit.edu	37	chr12	70066697	70066697	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtcaatgcaccagttagtttCaaaatcatcatcatcttctc	4	11	7	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:70066697C>G	uc001svg.2	-	8	1143	c.916G>C	c.(916-918)GAA>CAA	p.E306Q	BEST3_uc001svd.1_Missense_Mutation_p.E306Q|BEST3_uc001sve.1_RNA|BEST3_uc001svf.2_Missense_Mutation_p.E93Q|BEST3_uc010stm.1_Missense_Mutation_p.E200Q|BEST3_uc001svh.2_Missense_Mutation_p.E93Q	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	306	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CAGTTAGTTTCAAAATCATCA	0.274													0	0	0	0.080935	0	10	39										G	70066697	C	G	70066697	3	3	109	1	0	0	0	0	1	0	0	0	1406	835	29	1	1102	1	BEST3	12	70066697	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	13067789	70066697	63785198	218	33389										
PTPRB	5787	broad.mit.edu	37	chr12	70938355	70938355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acctgattcagtagtgatggGtaaagaaaaaaatgtgtctg	11	4	2	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:70938355G>A	uc001swb.3	-	20	4852	c.4822C>T	c.(4822-4824)CCC>TCC	p.P1608S	PTPRB_uc010sto.1_Missense_Mutation_p.P1518S|PTPRB_uc010stp.1_Missense_Mutation_p.P1518S|PTPRB_uc001swc.3_Missense_Mutation_p.P1826S|PTPRB_uc001swa.3_Missense_Mutation_p.P1738S	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1608	Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTAGTGATGGGTAAAGAAAAA	0.408													0	0	0	0.09319	0	12	15										A	70938355	G	A	70938355	3	1	109	1	0	0	0	0	1	0	0	0	12796	1261	44	2	1223	2	PTPRB	12	70938355	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	871658	70938355	62913540	219	33390										
LGR5	8549	broad.mit.edu	37	chr12	71977759	71977759	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	catctgttttcctgcttactCtggcagccctggagcgtggg	12	12	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:71977759C>G	uc001swl.2	+	18	2017	c.1969C>G	c.(1969-1971)CTG>GTG	p.L657V	LGR5_uc001swm.2_Missense_Mutation_p.L633V|LGR5_uc001swn.1_Intron	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	657	Helical; Name=3; (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						CCTGCTTACTCTGGCAGCCCT	0.448													0	0	0	0.108266	0	27	95										G	71977759	C	G	71977759	3	3	109	1	0	0	0	0	1	0	0	0	8757	912	32	1	2039	1	LGR5	12	71977759	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1039404	71977759	61874136	220	33391										
PAH	5053	broad.mit.edu	37	chr12	103246654	103246654	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgtgtgcagtggaagactcGgaaggccaggccacccaaga	14	11	0	2	rs5030850		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:103246654G>A	uc001tjq.1	-	8	1253	c.781C>T	c.(781-783)CGA>TGA	p.R261*		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	261			R -> P (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TGGAAGACTCGGAAGGCCAGG	0.542													0	0	0	0.021553	0	5	82										A	103246654	G	A	103246654	4	1	109	1	0	0	0	0	0	1	0	0	11394	1124	39	2	605	2	PAH	12	103246654	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	31268895	103246654	30605241	221	33392										
IFT81	28981	broad.mit.edu	37	chr12	110581342	110581342	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	attctgatcttcttgaacttGaatctaaagtaagtgagaat	7	5	4	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:110581342G>C	uc001tqi.2	+	9	1067	c.937G>C	c.(937-939)GAA>CAA	p.E313Q	IFT81_uc001tqh.2_Missense_Mutation_p.E313Q|IFT81_uc001tqj.2_RNA|IFT81_uc001tqg.2_Missense_Mutation_p.E313Q	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	313	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						TCTTGAACTTGAATCTAAAGT	0.308													0	0	0	0.083992	0	22	115										C	110581342	G	C	110581342	3	2	109	1	0	0	0	0	1	0	0	0	7565	1291	45	1	967	1	IFT81	12	110581342	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	7334688	110581342	23270553	222	33393										
NOS1	4842	broad.mit.edu	37	chr12	117662862	117662862	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gccgctgttgccagaagcttCggaaaggggcaatgccggtg	16	10	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:117662862C>T	uc001twm.1	-	25	4471	c.3785G>A	c.(3784-3786)CGA>CAA	p.R1262Q		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1262	NADP (By similarity).				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCAGAAGCTTCGGAAAGGGGC	0.617													0	0	0	0.11126	0	42	160										T	117662862	C	T	117662862	3	4	109	1	0	0	0	0	1	0	0	0	10541	884	31	1	539	1	NOS1	12	117662862	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	7081520	117662862	16189033	223	33394										
ZCCHC8	55596	broad.mit.edu	37	chr12	122958378	122958378	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcacctcagagtctggactgGaggcatgtccagcttctgat	11	11	4	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:122958378G>A	uc001ucn.2	-	14	1921	c.1790C>T	c.(1789-1791)TCC>TTC	p.S597F	ZCCHC8_uc001ucl.2_Missense_Mutation_p.S208F|ZCCHC8_uc001ucm.2_Missense_Mutation_p.S359F|ZCCHC8_uc009zxp.2_Missense_Mutation_p.S359F|ZCCHC8_uc009zxq.2_Missense_Mutation_p.S359F	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	597						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GTCTGGACTGGAGGCATGTCC	0.488													0	0	0	0.139131	0	52	201										A	122958378	G	A	122958378	3	1	109	1	0	0	0	0	1	0	0	0	17591	1174	41	1	337	1	ZCCHC8	12	122958378	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	5295516	122958378	10893517	224	33395										
ATP6V0A2	23545	broad.mit.edu	37	chr12	124236904	124236904	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agccaagatatagaagagggAaatcaccaggtggaagatgg	14	5	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:124236904A>T	uc001ufr.2	+	17	2378	c.2130A>T	c.(2128-2130)GGA>GGT	p.G710G		NM_012463	NP_036595	Q9Y487	VPP2_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	710	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|immune response|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.000625)|all cancers(50;0.00775)		TAGAAGAGGGAAATCACCAGG	0.398													0	0	0	0.09319	0	12	48										T	124236904	A	T	124236904	2	4	109	1	0	0	0	0	0	0	0	1	1169	233	9	5		5	ATP6V0A2	12	124236904	Silent	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	1278526	124236904	9614991	225	33396										
POLE	5426	broad.mit.edu	37	chr12	133210898	133210898	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctcttcctcctcctccccatCtctttcctcctcatcgtcct	1	22	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr12:133210898C>G	uc001uks.1	-	43	5922	c.5878G>C	c.(5878-5880)GAT>CAT	p.D1960H	POLE_uc001ukq.1_Missense_Mutation_p.D170H|POLE_uc001ukr.1_Missense_Mutation_p.D764H|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1960					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		tcctccccatctctttcctcc	0.333								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.038395	0	17	62										G	133210898	C	G	133210898	3	3	109	1	0	0	0	0	1	0	0	0	12196	913	32	1	1010	1	POLE	12	133210898	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	8973994	133210898	640997	226	33397										
RNF6	6049	broad.mit.edu	37	chr13	26793668	26793668	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gttcattaataaactgataaTaggcctcttctctgtggaga	8	7	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr13:26793668T>C	uc001uqo.2	-	3	410	c.119A>G	c.(118-120)TAT>TGT	p.Y40C	RNF6_uc001uqn.1_Missense_Mutation_p.Y40C|RNF6_uc010aak.2_Missense_Mutation_p.Y40C|RNF6_uc001uqp.2_Missense_Mutation_p.Y40C|RNF6_uc001uqq.2_Missense_Mutation_p.Y40C|RNF6_uc010tdk.1_5'UTR	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	40					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		AAACTGATAATAGGCCTCTTC	0.408													0	0	0	0.116897	0	29	67										C	26793668	T	C	26793668	3	2	109	1	0	0	0	0	1	0	0	0	13498	1406	49	5	1950	5	RNF6	13	26793668	Missense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08		26793668	88376210	227	33398										
SLC46A3	283537	broad.mit.edu	37	chr13	29287107	29287107	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtaacaaacagagcaaaaatCgtctcttaccagaagcattc	6	10	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr13:29287107C>T	uc001usi.2	-	2	1740	c.770G>A	c.(769-771)CGA>CAA	p.R257Q	SLC46A3_uc001usg.2_Missense_Mutation_p.R182Q|SLC46A3_uc001usj.2_Missense_Mutation_p.R257Q|SLC46A3_uc001ush.2_Missense_Mutation_p.R257Q|SLC46A3_uc001usk.2_Missense_Mutation_p.R182Q	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	257	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		GAGCAAAAATCGTCTCTTACC	0.338													0	0	0	0.047766	0	9	27										T	29287107	C	T	29287107	3	4	109	1	0	0	0	0	1	0	0	0	14646	884	31	1	645	1	SLC46A3	13	29287107	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2493439	29287107	85882771	228	33399										
DGKH	160851	broad.mit.edu	37	chr13	42623082	42623082	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatccgcaaagtgtctacctCggggcagatccggaccaagg	13	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr13:42623082C>G	uc001uyl.1	+	1	194	c.173C>G	c.(172-174)TCG>TGG	p.S58W	DGKH_uc010tfh.1_Missense_Mutation_p.S58W|DGKH_uc001uym.1_Missense_Mutation_p.S58W	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	58					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GTGTCTACCTCGGGGCAGATC	0.398													0	0	0	0.115264	0	2	6										G	42623082	C	G	42623082	3	3	109	1	0	0	0	0	1	0	0	0	4470	893	31	1	175	1	DGKH	13	42623082	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	13335975	42623082	72546796	229	33400										
PCDH20	64881	broad.mit.edu	37	chr13	61987145	61987145	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atccttagatgcttgtggaaCtttctgactgtaagaataag	9	6	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr13:61987145C>T	uc001vid.3	-	2	1451	c.1087G>A	c.(1087-1089)GTT>ATT	p.V363I	PCDH20_uc010thj.1_Missense_Mutation_p.V363I	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	336	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GCTTGTGGAACTTTCTGACTG	0.433													0	0	0	0.144211	0	31	76										T	61987145	C	T	61987145	3	4	109	1	0	0	0	0	1	0	0	0	11515	565	20	2	1772	2	PCDH20	13	61987145	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	19364063	61987145	53182733	230	33401										
LMO7	4008	broad.mit.edu	37	chr13	76427499	76427499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gccattccccttcagcttcaCagtcaggctctcagctgcgt	8	16	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr13:76427499C>A	uc001vjv.2	+	25	4697	c.3937C>A	c.(3937-3939)CAG>AAG	p.Q1313K	LMO7_uc010thv.1_Missense_Mutation_p.Q1264K|LMO7_uc010thw.1_Missense_Mutation_p.Q1190K	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1598						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTCAGCTTCACAGTCAGGCTC	0.542													1	0	7.03913e-09	0.09319	8.16318e-09	11	37										A	76427499	C	A	76427499	3	1	109	1	0	0	0	0	1	0	0	0	8855	479	17	4	4906	4	LMO7	13	76427499	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	14440354	76427499	38742379	231	33402										
MYCBP2	23077	broad.mit.edu	37	chr13	77825302	77825302	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttaccctccggggactctgtCtggccgtccactactgacac	9	16	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr13:77825302C>T	uc001vkf.2	-	16	2342	c.2251G>A	c.(2251-2253)GAC>AAC	p.D751N	MYCBP2_uc010aev.2_Missense_Mutation_p.D155N	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	751	Cys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGGACTCTGTCTGGCCGTCCA	0.468													0	0	0	0.0333	0	15	42										T	77825302	C	T	77825302	3	4	109	1	0	0	0	0	1	0	0	0	10018	913	32	1	11947	1	MYCBP2	13	77825302	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1397803	77825302	37344576	232	33403										
OR11H12	440153	broad.mit.edu	37	chr14	19377844	19377844	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cctgggaaatttctccttttTagagatatggtatgtctctt	8	7	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:19377844T>C	uc010tkp.1	+	1	251	c.251T>C	c.(250-252)TTA>TCA	p.L84S		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	84	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTCTCCTTTTTAGAGATATGG	0.418													0	0	0	0.139131	0	67	120										C	19377844	T	C	19377844	3	2	109	1	0	0	0	0	1	0	0	0	10927	1764	61	5	253	5	OR11H12	14	19377844	Missense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08		19377844	87971696	233	33404										
DDHD1	80821	broad.mit.edu	37	chr14	53539349	53539349	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtggactagtataatacattAtgtccattgcactgctgttc	8	8	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:53539349A>C	uc001xai.2	-	6	1699	c.1469T>G	c.(1468-1470)ATA>AGA	p.I490R	DDHD1_uc001xaj.2_Missense_Mutation_p.I497R|DDHD1_uc001xah.2_Missense_Mutation_p.I490R|DDHD1_uc001xag.2_Missense_Mutation_p.I72R	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	490					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					ATAATACATTATGTCCATTGC	0.338													0	0	0	0.0333	0	17	52										C	53539349	A	C	53539349	3	2	109	1	0	0	0	0	1	0	0	0	4326	449	16	5	1265	5	DDHD1	14	53539349	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	34161505	53539349	53810191	234	33405										
SAMD4A	23034	broad.mit.edu	37	chr14	55203778	55203778	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acaccacagccctttgaaacGatctgtgtcccttaccccac	5	17	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:55203778G>C	uc001xbb.2	+	3	750	c.749G>C	c.(748-750)CGA>CCA	p.R250P	SAMD4A_uc001xbc.2_Intron	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	251					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						CCTTTGAAACGATCTGTGTCC	0.502													0	0	0	0.139131	0	69	135										C	55203778	G	C	55203778	3	2	109	1	0	0	0	0	1	0	0	0	13821	1058	37	1	759	1	SAMD4A	14	55203778	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1664429	55203778	52145762	235	33406										
EIF2B2	8892	broad.mit.edu	37	chr14	75469786	75469786	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggtggtgggccgcgcagctcCgaggaaatggctcgggagac	19	10	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:75469786C>T	uc001xrc.1	+	1	175	c.93C>T	c.(91-93)TCC>TCT	p.S31S		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	31					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		CGCGCAGCTCCGAGGAAATGG	0.667													0	0	0	0.043863	0	19	39										T	75469786	C	T	75469786	2	4	109	1	0	0	0	0	0	0	0	1	5001	639	23	2		2	EIF2B2	14	75469786	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	20266008	75469786	31879754	236	33407										
C14orf148	122945	broad.mit.edu	37	chr14	77861083	77861083	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttggagaacaggactacttGagagatgctggctaaacgga	13	7	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:77861083G>C	uc001xtr.2	-	6	1118	c.971C>G	c.(970-972)TCA>TGA	p.S324*		NM_001113475	NP_001106946	Q6NXP6	CN148_HUMAN	hypothetical protein LOC122945 isoform 1	324					proline biosynthetic process		binding|pyrroline-5-carboxylate reductase activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		AGGACTACTTGAGAGATGCTG	0.443													0	0	0	0.132662	0	14	60										C	77861083	G	C	77861083	4	2	109	1	0	0	0	0	0	1	0	0	1751	1294	45	1	112	1	C14orf148	14	77861083	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2391297	77861083	29488457	237	33408										
GALC	2581	broad.mit.edu	37	chr14	88411957	88411957	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cggcagcccatgtaatgggtCtctggttgagaacttggcgt	14	9	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:88411957C>T	uc001xvt.2	-	14	2009	c.1610G>A	c.(1609-1611)AGA>AAA	p.R537K	GALC_uc010tvw.1_RNA|GALC_uc010tvx.1_Missense_Mutation_p.R511K|GALC_uc010tvy.1_Missense_Mutation_p.R514K|GALC_uc010tvz.1_Missense_Mutation_p.R481K	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	537					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						TGTAATGGGTCTCTGGTTGAG	0.428													0	0	0	0.139131	0	45	93										T	88411957	C	T	88411957	3	4	109	1	0	0	0	0	1	0	0	0	6201	913	32	1	463	1	GALC	14	88411957	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	10550874	88411957	18937583	238	33409										
MOAP1	64112	broad.mit.edu	37	chr14	93649993	93649993	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcgccttctcttctctacatCtggcacctgccacgccttta	5	17	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:93649993C>A	uc001ybj.2	-	3	965	c.595G>T	c.(595-597)GAT>TAT	p.D199Y	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	199					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ttctctacatctggcacctgc	0													1	0	1.5548e-18	0.108266	1.85155e-18	28	103										A	93649993	C	A	93649993	3	1	109	1	0	0	0	0	1	0	0	0	9680	913	32	3	464	3	MOAP1	14	93649993	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	5238036	93649993	13699547	239	33410										
PPP4R4	57718	broad.mit.edu	37	chr14	94732160	94732160	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcaagaaatccaaactgattCgaagccagtcttttaataat	5	8	2	2	rs147765941		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:94732160C>G	uc001ycs.1	+	22	2468	c.2314C>G	c.(2314-2316)CGA>GGA	p.R772G		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	772						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						CAAACTGATTCGAAGCCAGTC	0.368													0	0	0	0.080935	0	12	111										G	94732160	C	G	94732160	3	3	109	1	0	0	0	0	1	0	0	0	12405	876	31	1	2473	1	PPP4R4	14	94732160	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1082167	94732160	12617380	240	33411										
DICER1	23405	broad.mit.edu	37	chr14	95562205	95562205	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaggcatgtgtaaaagcctgGagaaggtaagccttattctt	12	6	1	1	rs145027662	byFrequency	TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:95562205G>A	uc001ydw.2	-	24	5234	c.5052C>T	c.(5050-5052)CTC>CTT	p.L1684L	DICER1_uc010avh.1_Silent_p.L582L|DICER1_uc001ydv.2_Silent_p.L1674L|DICER1_uc001ydx.2_Silent_p.L1684L|DICER1_uc001ydy.1_Silent_p.L536L	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1684	RNase III 2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TAAAAGCCTGGAGAAGGTAAG	0.393			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.045705	0	31	45										A	95562205	G	A	95562205	2	1	109	1	0	0	0	0	0	0	0	1	4521	1161	41	1		1	DICER1	14	95562205	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	830045	95562205	11787335	241	33412										
C14orf68	283600	broad.mit.edu	37	chr14	100793638	100793638	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cacatctgccggctccggtaCggcaaccctgacgccaagcc	10	18	1	1	rs147080547		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr14:100793638C>T	uc001yhc.2	+	4	331	c.258C>T	c.(256-258)TAC>TAT	p.Y86Y	C14orf68_uc001yhd.2_Translation_Start_Site	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	86					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				GGCTCCGGTACGGCAACCCTG	0.687													0	0	0	0.047766	0	7	122										T	100793638	C	T	100793638	2	4	109	1	0	0	0	0	0	0	0	1	1778	547	19	2		2	C14orf68	14	100793638	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	5231433	100793638	6555902	242	33413										
SPRED1	161742	broad.mit.edu	37	chr15	38643647	38643647	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttagttgcatgctctgtgcaGagagcatgttgtatcattgt	11	6	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:38643647G>A	uc001zka.3	+	7	1452	c.1117G>A	c.(1117-1119)GAG>AAG	p.E373K		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	373	SPR.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GCTCTGTGCAGAGAGCATGTT	0.423									Legius_syndrome				0	0	0	0.086207	0	42	104										A	38643647	G	A	38643647	3	1	109	1	0	0	0	0	1	0	0	0	15091	943	33	1	1143	1	SPRED1	15	38643647	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		38643647	63887745	243	33414										
DISP2	85455	broad.mit.edu	37	chr15	40659556	40659556	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tctaccaactcctgcactttCtgcttgacagggactttctg	7	13	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:40659556C>G	uc001zlk.1	+	8	1332	c.1243C>G	c.(1243-1245)CTG>GTG	p.L415V		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	415					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CCTGCACTTTCTGCTTGACAG	0.587													0	0	0	0.139131	0	86	276										G	40659556	C	G	40659556	3	3	109	1	0	0	0	0	1	0	0	0	4540	912	32	1	1273	1	DISP2	15	40659556	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2015909	40659556	61871836	244	33415										
ONECUT1	3175	broad.mit.edu	37	chr15	53081070	53081070	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccggccggatttgagtttgcTccagggtttggggttgcgca	16	9	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:53081070T>C	uc002aci.1	-	1	1140	c.1012A>G	c.(1012-1014)AGC>GGC	p.S338G		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	338	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)		TTGAGTTTGCTCCAGGGTTTG	0.652													0	0	0	0.062417	0	19	44										C	53081070	T	C	53081070	3	2	109	1	0	0	0	0	1	0	0	0	10868	1551	54	5	393	5	ONECUT1	15	53081070	Missense_Mutation	SNP	T	TCGA-GD-A2C5-01A-12D-A17V-08	12421514	53081070	49450322	245	33416										
ZNF280D	54816	broad.mit.edu	37	chr15	56950642	56950642	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cggagattttctgaatgcttCttaaaaatacaaaacctttt	5	7	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:56950642C>T	uc002adu.2	-	17	2254	c.2037G>A	c.(2035-2037)AAG>AAA	p.K679K	ZNF280D_uc002adv.2_Silent_p.K666K|ZNF280D_uc010bfq.2_Silent_p.K679K|ZNF280D_uc002adw.1_Silent_p.K707K|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	679					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		CTGAATGCTTCTTAAAAATAC	0.229													0	0	0	0.02938	0	5	38										T	56950642	C	T	56950642	2	4	109	1	0	0	0	0	0	0	0	1	17814	912	32	1		1	ZNF280D	15	56950642	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3869572	56950642	45580750	246	33417										
FAM96A	84191	broad.mit.edu	37	chr15	64380955	64380955	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aataaccagatattcttcttCatttatctcctgaacttcca	2	11	4	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:64380955C>T	uc002amt.1	-	2	460	c.220G>A	c.(220-222)GAA>AAA	p.E74K	FAM96A_uc002amu.1_Missense_Mutation_p.E74K|FAM96A_uc010uin.1_Missense_Mutation_p.E74K	NM_032231	NP_115607	Q9H5X1	FA96A_HUMAN	family with sequence similarity 96, member A	74					chromosome segregation						0						TATTCTTCTTCATTTATCTCC	0.378													0	0	0	0.047766	0	8	45										T	64380955	C	T	64380955	3	4	109	1	0	0	0	0	1	0	0	0	5654	835	29	1	278	1	FAM96A	15	64380955	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	7430313	64380955	38150437	247	33418										
FAM96A	84191	broad.mit.edu	37	chr15	64381003	64381003	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttccgagaccacttccagttCttctaaagtattgggctttt	7	10	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:64381003C>T	uc002amt.1	-	2	412	c.172G>A	c.(172-174)GAA>AAA	p.E58K	FAM96A_uc002amu.1_Missense_Mutation_p.E58K|FAM96A_uc010uin.1_Missense_Mutation_p.E58K	NM_032231	NP_115607	Q9H5X1	FA96A_HUMAN	family with sequence similarity 96, member A	58					chromosome segregation						0						ACTTCCAGTTCTTCTAAAGTA	0.363													0	0	0	0.105934	0	11	59										T	64381003	C	T	64381003	3	4	109	1	0	0	0	0	1	0	0	0	5654	922	32	1	326	1	FAM96A	15	64381003	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	48	64381003	38150389	248	33419										
IQCH	64799	broad.mit.edu	37	chr15	67649729	67649729	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cctccatctccagcagaagtGaagttctttcccaagaaaca	6	13	2	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:67649729G>C	uc002aqo.1	+	7	731	c.684G>C	c.(682-684)GTG>GTC	p.V228V	IQCH_uc010ujv.1_Silent_p.V60V|IQCH_uc002aqn.1_Silent_p.V55V|IQCH_uc002aqq.1_5'UTR|IQCH_uc002aqp.1_5'UTR	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	228										skin(3)|ovary(1)	4				Colorectal(3;0.0856)		CAGCAGAAGTGAAGTTCTTTC	0.383													0	0	0	0.080935	0	10	44										C	67649729	G	C	67649729	2	2	109	1	0	0	0	0	0	0	0	1	7811	1277	45	1		1	IQCH	15	67649729	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3268726	67649729	34881663	249	33420										
NOX5	79400	broad.mit.edu	37	chr15	69320560	69320560	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccttctcgcccacagtccttCtttgcagagcgattctttgc	7	15	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:69320560C>G	uc002ars.1	+	3	200	c.180C>G	c.(178-180)TTC>TTG	p.F60L	NOX5_uc002arp.1_Missense_Mutation_p.F42L|NOX5_uc002arq.1_Missense_Mutation_p.F42L|NOX5_uc010bid.1_Missense_Mutation_p.F53L|NOX5_uc002arr.1_Missense_Mutation_p.F60L|NOX5_uc010bie.1_5'UTR	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	60	Cytoplasmic (Potential).|N-terminal regulatory region; interacts with the C-terminal catalytic region in a calcium-dependent manner.|EF-hand 2.				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						CACAGTCCTTCTTTGCAGAGC	0.577													0	0	0	0.050027	0	29	159										G	69320560	C	G	69320560	3	3	109	1	0	0	0	0	1	0	0	0	10559	912	32	1	223	1	NOX5	15	69320560	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1670831	69320560	33210832	250	33421										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84657546	84657546	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atcatcttggttcagatgtgGaaagttcttctgtgctgtat	10	6	5	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:84657546G>A	uc002bjz.3	+	22	4044	c.3820G>A	c.(3820-3822)GAA>AAA	p.E1274K	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.E1274K|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.E1274K	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1274	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TTCAGATGTGGAAAGTTCTTC	0.318													0	0	0	0.080935	0	9	64										A	84657546	G	A	84657546	3	1	109	1	0	0	0	0	1	0	0	0	276	1175	41	1	3902	1	ADAMTSL3	15	84657546	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	15336986	84657546	17873846	251	33422										
SEMA4B	10509	broad.mit.edu	37	chr15	90771388	90771388	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctactgcccagaggtggtggAggacggggtggcagaccaaa	17	9	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:90771388A>T	uc002boy.2	+	15	2310	c.2027A>T	c.(2026-2028)GAG>GTG	p.E676V	SEMA4B_uc002boz.2_Missense_Mutation_p.E676V|SEMA4B_uc010uqd.1_Missense_Mutation_p.E514V|SEMA4B_uc002bpa.2_Missense_Mutation_p.E514V|SEMA4B_uc010bnv.1_Missense_Mutation_p.E314V	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			GAGGTGGTGGAGGACGGGGTG	0.622													0	0	0	0.069234	0	11	14										T	90771388	A	T	90771388	3	4	109	1	0	0	0	0	1	0	0	0	14032	304	11	5	2081	5	SEMA4B	15	90771388	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	6113842	90771388	11760004	252	33423										
CHD2	1106	broad.mit.edu	37	chr15	93467681	93467681	+	Missense_Mutation	SNP	G	G	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aatcttctgagagtcagtcgGaatctgagagcgaatcagca							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:93467681G>A	uc002bsp.2	+	3	768	c.193G>A	c.(193-195)GAA>AAA	p.E65K	CHD2_uc002bsm.1_Missense_Mutation_p.E65K|CHD2_uc002bsn.2_Missense_Mutation_p.E65K|CHD2_uc002bso.1_Missense_Mutation_p.E65K|CHD2_uc010urb.1_Missense_Mutation_p.E78K	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	65	Ser-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GAGTCAGTCGGAATCTGAGAG	0.522													0	0	0	0.139131	0	55	111										A	93467681	G	A	93467681	3	1	109	1	0	0	0	0	1	0	0	0	3325	1175	41	1	199	1	CHD2	15	93467681	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2696293	93467681	9063711	253	33424	168	2								
CHD2	1106	broad.mit.edu	37	chr15	93467687	93467687	+	Missense_Mutation	SNP	G	G	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgagagtcagtcggaatctGagagcgaatcagcaggttcc							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr15:93467687G>A	uc002bsp.2	+	3	774	c.199G>A	c.(199-201)GAG>AAG	p.E67K	CHD2_uc002bsm.1_Missense_Mutation_p.E67K|CHD2_uc002bsn.2_Missense_Mutation_p.E67K|CHD2_uc002bso.1_Missense_Mutation_p.E67K|CHD2_uc010urb.1_Missense_Mutation_p.E80K	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	67	Ser-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GTCGGAATCTGAGAGCGAATC	0.522													0	0	0	0.139131	0	63	106										A	93467687	G	A	93467687	3	1	109	1	0	0	0	0	1	0	0	0	3325	1291	45	1	205	1	CHD2	15	93467687	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6	93467687	9063705	254	33425	168	2								
SPSB3	90864	broad.mit.edu	37	chr16	1828497	1828497	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gccgagtgcaggctgctacaGaaggaggcctcgctctgccc	14	14	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:1828497G>A	uc002cmr.2	-	2	276	c.243C>T	c.(241-243)TTC>TTT	p.F81F	SPSB3_uc002cms.2_5'UTR|SPSB3_uc002cmt.2_5'UTR|SPSB3_uc002cmu.2_Silent_p.F81F|SPSB3_uc002cmv.2_5'UTR|SPSB3_uc010uvm.1_Silent_p.F136F	NM_080861	NP_543137	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box	81					intracellular signal transduction						0						GGCTGCTACAGAAGGAGGCCT	0.697													0	0	0	0.080935	0	12	28										A	1828497	G	A	1828497	2	1	109	1	0	0	0	0	0	0	0	1	15113	933	33	1		1	SPSB3	16	1828497	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		1828497	88526256	255	33426										
ABCC1	4363	broad.mit.edu	37	chr16	16232288	16232288	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agacgaagatccttgtgttgGatgaggccacggcagccgtg	15	9	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:16232288G>A	uc010bvi.2	+	30	4535	c.4360G>A	c.(4360-4362)GAT>AAT	p.D1454N	ABCC1_uc010bvj.2_Missense_Mutation_p.D1395N|ABCC1_uc010bvk.2_Missense_Mutation_p.D1398N|ABCC1_uc010bvl.2_Intron|ABCC1_uc010bvm.2_Missense_Mutation_p.D1339N|ABCC1_uc002del.3_Missense_Mutation_p.D1348N	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1454	ABC transporter 2.|Cytoplasmic.			DE->LL: Impairs leukotriene C4 transport.	hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCTTGTGTTGGATGAGGCCAC	0.602													0	0	0	0.069234	0	10	32										A	16232288	G	A	16232288	3	1	109	1	0	0	0	0	1	0	0	0	49	1174	41	1	4478	1	ABCC1	16	16232288	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	14403791	16232288	74122465	256	33427										
SRCAP	10847	broad.mit.edu	37	chr16	30749639	30749639	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggctggtaactgtggtagagGaaaaggaactggtgcggcgg	19	5	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:30749639G>A	uc002dze.1	+	34	8663	c.8278G>A	c.(8278-8280)GAA>AAA	p.E2760K	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.E2555K	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2760	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGTGGTAGAGGAAAAGGAACT	0.627													0	0	0	0.038147	0	7	71										A	30749639	G	A	30749639	3	1	109	1	0	0	0	0	1	0	0	0	15134	1175	41	1	8404	1	SRCAP	16	30749639	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	14517351	30749639	59605114	257	33428										
STX4	6810	broad.mit.edu	37	chr16	31051064	31051064	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aagaaagtcttgattgccatCtgtgtgtccatcaccgtcgt	9	10	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:31051064C>G	uc002eal.2	+	10	1058	c.834C>G	c.(832-834)ATC>ATG	p.I278M	STX4_uc002eak.2_Missense_Mutation_p.I276M|STX4_uc002eam.2_Missense_Mutation_p.I200M|uc002ean.1_5'Flank	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	278	Helical; Anchor for type IV membrane protein; (Potential).|Interaction with CENPF (By similarity).				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						TGATTGCCATCTGTGTGTCCA	0.587													0	0	0	0.139131	0	49	185										G	31051064	C	G	31051064	3	3	109	1	0	0	0	0	1	0	0	0	15346	903	32	1	872	1	STX4	16	31051064	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	301425	31051064	59303689	258	33429										
ITGAD	3681	broad.mit.edu	37	chr16	31422500	31422500	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccattactatgagcagacccGagggggccaggtgtccgtgt	14	11	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:31422500G>A	uc002ebv.1	+	13	1509	c.1460G>A	c.(1459-1461)CGA>CAA	p.R487Q	ITGAD_uc010cap.1_Missense_Mutation_p.R487Q	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	487	Extracellular (Potential).|FG-GAP 5.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						GAGCAGACCCGAGGGGGCCAG	0.642													0	0	0	0.099896	0	25	97										A	31422500	G	A	31422500	3	1	109	1	0	0	0	0	1	0	0	0	7884	1058	37	1	1510	1	ITGAD	16	31422500	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	371436	31422500	58932253	259	33430										
HEATR3	55027	broad.mit.edu	37	chr16	50118104	50118104	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atgaaagtgacgcatttatgGagaattccttcagtgagtgc	11	6	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:50118104G>T	uc002efw.2	+	9	1354	c.1192G>T	c.(1192-1194)GAG>TAG	p.E398*	HEATR3_uc002efx.2_Nonsense_Mutation_p.E312*	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	398							binding			ovary(1)|skin(1)	2						CGCATTTATGGAGAATTCCTT	0.502													1	0	5.50884e-06	0.09319	6.32232e-06	12	155										T	50118104	G	T	50118104	4	4	109	1	0	0	0	0	0	1	0	0	7029	1175	41	3	1226	3	HEATR3	16	50118104	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	18695604	50118104	40236649	260	33431										
BRD7	29117	broad.mit.edu	37	chr16	50354583	50354583	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gagacacttaccttcagagtCaaaaacttcaactggaacgc	7	11	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:50354583C>G	uc002egf.1	-	15	1670	c.1603G>C	c.(1603-1605)GAC>CAC	p.D535H	BRD7_uc002ege.1_Missense_Mutation_p.D536H	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	535					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				CCTTCAGAGTCAAAAACTTCA	0.433													0	0	0	0.0918	0	26	410										G	50354583	C	G	50354583	3	3	109	1	0	0	0	0	1	0	0	0	1505	826	29	1	368	1	BRD7	16	50354583	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	236479	50354583	40000170	261	33432										
IRX5	10265	broad.mit.edu	37	chr16	54966652	54966652	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acccaggtgtccacctggttCgccaacgcgcgccggcgcct	12	18	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:54966652C>T	uc002ehv.2	+	2	492	c.492C>T	c.(490-492)TTC>TTT	p.F164F	IRX5_uc010cca.1_Silent_p.F216F|IRX5_uc002ehw.2_Silent_p.F98F	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	164	Homeobox; TALE-type.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						CCACCTGGTTCGCCAACGCGC	0.597													0	0	0	0.116897	0	28	205										T	54966652	C	T	54966652	2	4	109	1	0	0	0	0	0	0	0	1	7847	883	31	1		1	IRX5	16	54966652	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4612069	54966652	35388101	262	33433										
CDH11	1009	broad.mit.edu	37	chr16	64981702	64981702	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agtcataaggaggagccgtgGggtcattgtctgcctcctgt	14	9	3	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:64981702G>T	uc002eoi.2	-	13	2629	c.2195C>A	c.(2194-2196)CCC>CAC	p.P732H	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Missense_Mutation_p.P606H	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	732	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AGGAGCCGTGGGGTCATTGTC	0.562			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			1	0	1.50598e-64	0.139131	1.81785e-64	151	79										T	64981702	G	T	64981702	3	4	109	1	0	0	0	0	1	0	0	0	3097	1232	43	4	199	4	CDH11	16	64981702	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	10015050	64981702	25373051	263	33434										
TERF2	7014	broad.mit.edu	37	chr16	69419321	69419321	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttccccttcttcaatccgcgAcagacactgcataacccgca	5	17	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:69419321A>G	uc002exd.2	-	2	447	c.322T>C	c.(322-324)TCG>CCG	p.S108P	TERF2_uc002exe.2_Missense_Mutation_p.S108P	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	108	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				TCAATCCGCGACAGACACTGC	0.488													0	0	0	0.139131	0	45	346										G	69419321	A	G	69419321	3	3	109	1	0	0	0	0	1	0	0	0	15759	275	10	5	1216	5	TERF2	16	69419321	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	4437619	69419321	20935432	264	33435										
HYDIN	54768	broad.mit.edu	37	chr16	70908274	70908274	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctcagagatacttatgtcttCctggctggtgggggccacca	12	11	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr16:70908274C>T	uc002ezr.2	-	64	11007	c.10879G>A	c.(10879-10881)GAA>AAA	p.E3627K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3628										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTTATGTCTTCCTGGCTGGTG	0.507													0	0	0	0.076483	0	19	223										T	70908274	C	T	70908274	3	4	109	1	0	0	0	0	1	0	0	0	7467	864	30	1	4575	1	HYDIN	16	70908274	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1488953	70908274	19446479	265	33436										
KIAA0753	9851	broad.mit.edu	37	chr17	6526348	6526348	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctcccctcggtcagtaaactGagtgacaaacatctgtaagg	9	11	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:6526348G>C	uc002gde.3	-	6	1317	c.958C>G	c.(958-960)CAG>GAG	p.Q320E	KIAA0753_uc010vtd.1_5'Flank|KIAA0753_uc010clo.2_Missense_Mutation_p.Q21E|KIAA0753_uc010vte.1_Missense_Mutation_p.Q21E	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	320						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		TCAGTAAACTGAGTGACAAAC	0.498													0	0	0	0.105934	0	13	35										C	6526348	G	C	6526348	3	2	109	1	0	0	0	0	1	0	0	0	8191	1299	45	1	2001	1	KIAA0753	17	6526348	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		6526348	74668862	266	33437										
TP53	7157	broad.mit.edu	37	chr17	7577539	7577539	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatggtgaggatgggcctccGgttcatgccgcccatgcagg	16	11	1	1	rs121912651		TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:7577539G>A	uc002gim.2	-	7	936	c.742C>T	c.(742-744)CGG>TGG	p.R248W	TP53_uc002gig.1_Missense_Mutation_p.R248W|TP53_uc002gih.2_Missense_Mutation_p.R248W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116W|TP53_uc010cng.1_Missense_Mutation_p.R116W|TP53_uc002gii.1_Missense_Mutation_p.R116W|TP53_uc010cnh.1_Missense_Mutation_p.R248W|TP53_uc010cni.1_Missense_Mutation_p.R248W|TP53_uc002gij.2_Missense_Mutation_p.R248W|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155W|TP53_uc002gio.2_Missense_Mutation_p.R116W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(516)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGGCCTCCGGTTCATGCCG	0.577	R248W(CAS1_CENTRAL_NERVOUS_SYSTEM)|R248W(COLO680N_OESOPHAGUS)|R248W(SW837_LARGE_INTESTINE)|R248W(KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(RD_SOFT_TISSUE)|R248W(VCAP_PROSTATE)|R248W(JIMT1_BREAST)|R248W(GCT_SOFT_TISSUE)|R248W(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248W(786O_KIDNEY)|R248W(COLO320_LARGE_INTESTINE)|R248W(LXF289_LUNG)|R248W(LUDLU1_LUNG)|R248W(MIAPACA2_PANCREAS)|R248W(HCC2157_BREAST)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.117977	0	39	25										A	7577539	G	A	7577539	3	1	109	1	0	0	0	0	1	0	0	0	16378	1115	39	2	548	2	TP53	17	7577539	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1051191	7577539	73617671	267	33438										
DNAH2	146754	broad.mit.edu	37	chr17	7680153	7680153	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatgtcaccaagtgcctgctGacagcgaaggagcgggcaga	15	10	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:7680153G>A	uc002giu.1	+	31	5018	c.5004G>A	c.(5002-5004)CTG>CTA	p.L1668L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1668	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGTGCCTGCTGACAGCGAAGG	0.448													0	0	0	0.038395	0	14	6										A	7680153	G	A	7680153	2	1	109	1	0	0	0	0	0	0	0	1	4602	1277	45	1		1	DNAH2	17	7680153	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	102614	7680153	73515057	268	33439										
DNAH9	1770	broad.mit.edu	37	chr17	11700983	11700983	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	actttgcaaatggtattgggGagcccaaatacatgcctgta	10	8	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:11700983G>A	uc002gne.2	+	43	8361	c.8293G>A	c.(8293-8295)GAG>AAG	p.E2765K	DNAH9_uc010coo.2_Missense_Mutation_p.E2059K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2765					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGGTATTGGGGAGCCCAAATA	0.498													0	0	0	0.058154	0	10	33										A	11700983	G	A	11700983	3	1	109	1	0	0	0	0	1	0	0	0	4608	1175	41	1	8463	1	DNAH9	17	11700983	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	4020830	11700983	69494227	269	33440										
KIAA0100	9703	broad.mit.edu	37	chr17	26966333	26966334	+	Frame_Shift_Ins	INS	-	-	T													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgaaaaagatcagactgaccINStttttttcctttgctttaga							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:26966333_26966334insT	uc002hbu.2	-	11	1327_1328	c.1228_1229insA	c.(1228-1230)AGAfs	p.R410fs	KIAA0100_uc002hbv.2_Frame_Shift_Ins_p.R410fs	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	410						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TCAGACTGACCTTTTTTTCCTT	0.436																		97	135	---	---								T	26966334	-	T	26966333	7	5	109	1	0	1	1	0	0	0	0	0	8154	695	24	0	5594	0	KIAA0100	17	26966333	Frame_Shift_Ins	INS	-	TCGA-GD-A2C5-01A-12D-A17V-08	15265350	26966333	54228877	270	33441										
KIAA0100	9703	broad.mit.edu	37	chr17	26966617	26966617	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acactagccttgagggagttGaggcagacaatgcgttggcg	15	8	0	3	rs147060997	by1000genomes	TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:26966617G>C	uc002hbu.2	-	10	1158	c.1059C>G	c.(1057-1059)CTC>CTG	p.L353L	KIAA0100_uc002hbv.2_Silent_p.L353L|KIAA0100_uc010crr.1_3'UTR	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	353						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TGAGGGAGTTGAGGCAGACAA	0.473													0	0	0	0.11911	0	14	147										C	26966617	G	C	26966617	2	2	109	1	0	0	0	0	0	0	0	1	8154	1277	45	1		1	KIAA0100	17	26966617	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	284	26966617	54228593	271	33442										
PHF12	57649	broad.mit.edu	37	chr17	27235835	27235835	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	agggttcgatagcacatgttCacagctcctcccaaccctaa	7	14	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:27235835C>T	uc002hdg.1	-	12	2954	c.2424G>A	c.(2422-2424)GTG>GTA	p.V808V	PHF12_uc010wbb.1_Silent_p.V790V	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	808					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			AGCACATGTTCACAGCTCCTC	0.507													0	0	0	0.058154	0	8	64										T	27235835	C	T	27235835	2	4	109	1	0	0	0	0	0	0	0	1	11823	813	29	1		1	PHF12	17	27235835	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	269218	27235835	53959375	272	33443										
PIPOX	51268	broad.mit.edu	37	chr17	27379941	27379941	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gacttattttttaacaggcaGactggattactgctgctggg	11	7	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:27379941G>A	uc002hdr.1	+	3	593	c.267G>A	c.(265-267)CAG>CAA	p.Q89Q		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	89					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	TTAACAGGCAGACTGGATTAC	0.323													0	0	0	0.059317	0	35	21										A	27379941	G	A	27379941	2	1	109	1	0	0	0	0	0	0	0	1	11943	933	33	1		1	PIPOX	17	27379941	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	144106	27379941	53815269	273	33444										
ACACA	31	broad.mit.edu	37	chr17	35479509	35479509	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gatacttagttctactgttcGggtttctacagcaacaactc	7	10	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:35479509G>A	uc002hnm.2	-	49	6162	c.5971C>T	c.(5971-5973)CGA>TGA	p.R1991*	ACACA_uc002hnk.2_Nonsense_Mutation_p.R1913*|ACACA_uc002hnl.2_Nonsense_Mutation_p.R1933*|ACACA_uc002hnn.2_Nonsense_Mutation_p.R1991*|ACACA_uc002hno.2_Nonsense_Mutation_p.R2028*|ACACA_uc010cuy.2_Nonsense_Mutation_p.R636*|ACACA_uc010wdb.1_Nonsense_Mutation_p.R29*|ACACA_uc010wdc.1_Nonsense_Mutation_p.R117*	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1991	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TCTACTGTTCGGGTTTCTACA	0.463													0	0	0	0.099896	0	24	117										A	35479509	G	A	35479509	4	1	109	1	0	0	0	0	0	1	0	0	106	1124	39	2	1101	2	ACACA	17	35479509	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	8099568	35479509	45715701	274	33445										
KRT39	390792	broad.mit.edu	37	chr17	39120762	39120762	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cgagaccagtctggaattctCggccttggtacacaagatct	10	11	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:39120762C>T	uc002hvo.1	-	2	523	c.487G>A	c.(487-489)GAG>AAG	p.E163K	KRT39_uc010wfm.1_5'UTR	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	163	Rod.|Coil 1B.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				CTGGAATTCTCGGCCTTGGTA	0.443													0	0	0	0.069456	0	38	131										T	39120762	C	T	39120762	3	4	109	1	0	0	0	0	1	0	0	0	8476	893	31	1	1012	1	KRT39	17	39120762	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3641253	39120762	42074448	275	33446										
FKBP10	60681	broad.mit.edu	37	chr17	39973408	39973408	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	catgtgtgtcaacgagcggcGacgcctcattgtgcctcccc	11	15	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:39973408G>A	uc002hxv.2	+	2	669	c.344G>A	c.(343-345)CGA>CAA	p.R115Q	FKBP10_uc002hxw.1_5'Flank	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	115	PPIase FKBP-type 1.		Missing (in OI6).		protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		AACGAGCGGCGACGCCTCATT	0.647													0	0	0	0.132662	0	16	68										A	39973408	G	A	39973408	3	1	109	1	0	0	0	0	1	0	0	0	5902	1058	37	1	350	1	FKBP10	17	39973408	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	852646	39973408	41221802	276	33447										
HOXB4	3214	broad.mit.edu	37	chr17	46654260	46654260	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcagagcgcgtgggcgatctCcaccctccggcgccgtgtca	14	16	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:46654260C>G	uc002inp.2	-	2	642	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	194	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGGGCGATCTCCACCCTCCGG	0.602													0	0	0	0.064281	0	35	136										G	46654260	C	G	46654260	3	3	109	1	0	0	0	0	1	0	0	0	7303	864	30	1	179	1	HOXB4	17	46654260	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	6680852	46654260	34540950	277	33448										
HOXB8	3218	broad.mit.edu	37	chr17	46691841	46691841	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggggtccccgtggcacgccaCggcgcacgggttctgctggt	17	14	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:46691841C>T	uc002inw.2	-	1	461	c.226G>A	c.(226-228)GTG>ATG	p.V76M		NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	76						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TGGCACGCCACGGCGCACGGG	0.662													0	0	0	0.11911	0	13	46										T	46691841	C	T	46691841	3	4	109	1	0	0	0	0	1	0	0	0	7307	536	19	2	513	2	HOXB8	17	46691841	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	37581	46691841	34503369	278	33449										
EPN3	55040	broad.mit.edu	37	chr17	48618226	48618226	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccctggtctccgatcccctCaggaaccgtcctgtcccgaa	8	19	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:48618226C>T	uc002ira.3	+	7	1487	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.S379L|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.S324L	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	351	5 X 3 AA repeats of [DE]-P-W.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCGATCCCCTCAGGAACCGTC	0.632													0	0	0	0.09319	0	12	43										T	48618226	C	T	48618226	3	4	109	1	0	0	0	0	1	0	0	0	5187	838	29	1	1074	1	EPN3	17	48618226	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1926385	48618226	32576984	279	33450										
WFIKKN2	124857	broad.mit.edu	37	chr17	48918001	48918001	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgtcgggcctgcaagcctcGgcagaagctcgttaccagct	12	14	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:48918001G>C	uc002isv.3	+	2	2046	c.1352G>C	c.(1351-1353)CGG>CCG	p.R451P	WFIKKN2_uc010dbu.2_Missense_Mutation_p.R358P	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	451	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TGCAAGCCTCGGCAGAAGCTC	0.647													0	0	0	0.021553	0	6	81										C	48918001	G	C	48918001	3	2	109	1	0	0	0	0	1	0	0	0	17356	1116	39	4	1358	4	WFIKKN2	17	48918001	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	299775	48918001	32277209	280	33451										
CACNG4	27092	broad.mit.edu	37	chr17	64961035	64961035	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgaggcgcccaccatggtgcGatgcgaccgcgggctgcaga	16	13	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:64961035G>C	uc002jft.1	+	1	23	c.8G>C	c.(7-9)CGA>CCA	p.R3P		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	3	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			ACCATGGTGCGATGCGACCGC	0.453													0	0	0	0.014758	0	5	8										C	64961035	G	C	64961035	3	2	109	1	0	0	0	0	1	0	0	0	2559	1058	37	1	10	1	CACNG4	17	64961035	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	16043034	64961035	16234175	281	33452										
AFMID	125061	broad.mit.edu	37	chr17	76187059	76187059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgtgccctgcaggagctggaGaatcagtactgtcccagccg	13	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:76187059G>C	uc002jva.3	+	2	87	c.72G>C	c.(70-72)GAG>GAC	p.E24D	AFMID_uc002juy.3_RNA|AFMID_uc010dhj.2_Missense_Mutation_p.E24D|AFMID_uc002jvb.3_Missense_Mutation_p.E24D|AFMID_uc002juz.3_Missense_Mutation_p.E24D	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	24						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			AGGAGCTGGAGAATCAGTACT	0.572													0	0	0	0.080935	0	11	20										C	76187059	G	C	76187059	3	2	109	1	0	0	0	0	1	0	0	0	362	933	33	1	78	1	AFMID	17	76187059	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	11226024	76187059	5008151	282	33453										
DNAH17	8632	broad.mit.edu	37	chr17	76435210	76435210	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcctttctctgcagccacgtCcagggcgttctcagccacca	8	17	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:76435210C>T	uc010dhp.1	-	18	2989	c.2767G>A	c.(2767-2769)GAC>AAC	p.D923N	DNAH17_uc002jvq.2_Missense_Mutation_p.D208N|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCAGCCACGTCCAGGGCGTTC	0.552													0	0	0	0.11911	0	14	45										T	76435210	C	T	76435210	3	4	109	1	0	0	0	0	1	0	0	0	4601	855	30	1	1657	1	DNAH17	17	76435210	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	248151	76435210	4760000	283	33454										
CARD14	79092	broad.mit.edu	37	chr17	78156494	78156494	+	Frame_Shift_Del	DEL	C	C	-													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gactcgagggaagaacggggCcatcgccttcctggagagcc							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:78156494delC	uc002jxw.1	+	3	449	c.254delC	c.(253-255)GCCfs	p.A85fs	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Frame_Shift_Del_p.A85fs|CARD14_uc010wud.1_5'Flank	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	85	CARD.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AAGAACGGGGCCATCGCCTTC	0.592																		19	41	---	---								-	78156494	C	-	78156494	7	5	109	1	0	1	0	1	0	0	0	0	2646	739	26	0	260	0	CARD14	17	78156494	Frame_Shift_Del	DEL	C	TCGA-GD-A2C5-01A-12D-A17V-08	1721284	78156494	3038716	284	33455										
PYCR1	5831	broad.mit.edu	37	chr17	79891091	79891091	+	Nonstop_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggtggtcaggcaggacgtgtCaatccttgcccgctggggcc	16	12	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr17:79891091C>G	uc002kcr.1	-	7	1237	c.959G>C	c.(958-960)TGA>TCA	p.*320S	PYCR1_uc002kcq.1_3'UTR|PYCR1_uc002kcp.2_Intron|PYCR1_uc002kcs.1_3'UTR|PYCR1_uc010wvd.1_Nonstop_Mutation_p.*347S|PYCR1_uc002kct.1_Nonstop_Mutation_p.*320S|PYCR1_uc002kcu.1_Nonstop_Mutation_p.*289S	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	320					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	CAGGACGTGTCAATCCTTGCC	0.622													0	0	0	0.074837	0	32	48										G	79891091	C	G	79891091	4	3	109	1	0	0	0	0	0	0	0	0	12855	837	29	1	92	1	PYCR1	17	79891091	Nonstop_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1734597	79891091	1304119	285	33456										
RALBP1	10928	broad.mit.edu	37	chr18	9535846	9535846	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cgcccagagacggcgtccttGagccaaaagcagctaaagag	12	12	0	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr18:9535846G>C	uc002kob.2	+	10	2102	c.1879G>C	c.(1879-1881)GAG>CAG	p.E627Q	RALBP1_uc002koc.2_Missense_Mutation_p.E627Q	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	627					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						CGGCGTCCTTGAGCCAAAAGC	0.657													0	0	0	0.014758	0	4	9										C	9535846	G	C	9535846	3	2	109	1	0	0	0	0	1	0	0	0	13012	1291	45	1	1913	1	RALBP1	18	9535846	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		9535846	68541402	286	33457										
FAM59A	64762	broad.mit.edu	37	chr18	29867522	29867522	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcttcattccagtcggttttCacatcacggacagcccgtga	8	13	4	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr18:29867522C>T	uc002kxl.2	-	4	1094	c.1038G>A	c.(1036-1038)GTG>GTA	p.V346V	FAM59A_uc002kxk.1_Silent_p.V346V	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	346										ovary(1)|skin(1)	2						AGTCGGTTTTCACATCACGGA	0.557													0	0	0	0.076483	0	24	109										T	29867522	C	T	29867522	2	4	109	1	0	0	0	0	0	0	0	1	5592	813	29	1		1	FAM59A	18	29867522	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	20331676	29867522	48209726	287	33458										
ASXL3	80816	broad.mit.edu	37	chr18	31318552	31318552	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gacttctggccttccagtttCtgcacagacagccttggcag	10	13	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr18:31318552C>G	uc010dmg.1	+	11	1239	c.1184C>G	c.(1183-1185)TCT>TGT	p.S395C	ASXL3_uc002kxq.2_Missense_Mutation_p.S102C	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CTTCCAGTTTCTGCACAGACA	0.488													0	0	0	0.115264	0	3	39										G	31318552	C	G	31318552	3	3	109	1	0	0	0	0	1	0	0	0	1068	913	32	1	1226	1	ASXL3	18	31318552	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1451030	31318552	46758696	288	33459										
SLC39A6	25800	broad.mit.edu	37	chr18	33689640	33689640	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccaaaagcatcccagcattCtgtaaaaagaaataccccca	4	14	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr18:33689640C>T	uc010dmy.2	-	10	2474	c.2184G>A	c.(2182-2184)CAG>CAA	p.Q728Q		NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	728	Helical; Name=6; (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						TCCCAGCATTCTGTAAAAAGA	0.343													0	0	0	0.059317	0	32	166										T	33689640	C	T	33689640	2	4	109	1	0	0	0	0	0	0	0	1	14622	912	32	1		1	SLC39A6	18	33689640	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2371088	33689640	44387608	289	33460										
STARD6	147323	broad.mit.edu	37	chr18	51851180	51851180	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcatggttttttcaattattGatggggacaattttcctctc	8	7	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr18:51851180G>C	uc010xdt.1	-	6	545	c.545C>G	c.(544-546)TCA>TGA	p.S182*		NM_139171	NP_631910	P59095	STAR6_HUMAN	START domain containing protein 6	182	START.				lipid transport		lipid binding			ovary(1)	1				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		TTCAATTATTGATGGGGACAA	0.358													0	0	0	0.047766	0	8	41										C	51851180	G	C	51851180	4	2	109	1	0	0	0	0	0	1	0	0	15260	1294	45	1	120	1	STARD6	18	51851180	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	18161540	51851180	26226068	290	33461										
CSNK1G2	1455	broad.mit.edu	37	chr19	1978449	1978449	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttgtgcccccaggagccgatCaagtcccgggccccgcagct	12	17	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:1978449C>T	uc002lul.3	+	5	760	c.237C>T	c.(235-237)ATC>ATT	p.I79I	CSNK1G2_uc010dsu.2_Silent_p.I31I	NM_001319	NP_001310	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	79	Protein kinase.				sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			stomach(1)	1		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAGCCGATCAAGTCCCGGG	0.597													0	0	0	0.009096	0	4	13										T	1978449	C	T	1978449	2	4	109	1	0	0	0	0	0	0	0	1	3955	816	29	1		1	CSNK1G2	19	1978449	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		1978449	57150534	291	33462										
SH2D3A	10045	broad.mit.edu	37	chr19	6752630	6752630	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtcaggctccaggcgctgcgAcaggacgccgaggacgcgct	16	14	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:6752630A>G	uc002mft.2	-	10	1899	c.1705T>C	c.(1705-1707)TCG>CCG	p.S569P	SH2D3A_uc010xjg.1_Missense_Mutation_p.S476P	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	569					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						AGGCGCTGCGACAGGACGCCG	0.667													0	0	0	0.115264	0	2	4										G	6752630	A	G	6752630	3	3	109	1	0	0	0	0	1	0	0	0	14233	275	10	5	29	5	SH2D3A	19	6752630	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	4774181	6752630	52376353	292	33463										
TIMM44	10469	broad.mit.edu	37	chr19	7992973	7992973	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggtgcttacgtcgacgttgtCaatgtctaggatgcgagaat	13	7	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:7992973C>T	uc002miz.2	-	11	1119	c.1117G>A	c.(1117-1119)GAC>AAC	p.D373N	TIMM44_uc002mja.2_Missense_Mutation_p.D113N|TIMM44_uc010dvx.1_RNA|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	373					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						TCGACGTTGTCAATGTCTAGG	0.637													0	0	0	0.02938	0	6	26										T	7992973	C	T	7992973	3	4	109	1	0	0	0	0	1	0	0	0	15909	826	29	1	253	1	TIMM44	19	7992973	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1240343	7992973	51136010	293	33464										
ACTL9	284382	broad.mit.edu	37	chr19	8808334	8808334	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctgctgtcccaggggcaggcCggcctggagcagcatctccg	15	15	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:8808334C>T	uc002mkl.2	-	1	839	c.718G>A	c.(718-720)GGC>AGC	p.G240S		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	240						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						AGGGGCAGGCCGGCCTGGAGC	0.657													0	0	0	0.11911	0	14	45										T	8808334	C	T	8808334	3	4	109	1	0	0	0	0	1	0	0	0	203	652	23	2	536	2	ACTL9	19	8808334	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	815361	8808334	50320649	294	33465										
MUC16	94025	broad.mit.edu	37	chr19	9073469	9073470	+	Frame_Shift_Ins	INS	-	-	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtctactgctggctactgagINSaaaatatctgggaactttgt							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:9073469_9073470insA	uc002mkp.2	-	3	14180_14181	c.13976_13977insT	c.(13975-13977)TTCfs	p.F4659fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4661	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCTACTGAGAAAATATCTGG	0.455																		53	116	---	---								A	9073470	-	A	9073469	7	5	109	1	0	1	1	0	0	0	0	0	9973	933	33	0	29874	0	MUC16	19	9073469	Frame_Shift_Ins	INS	-	TCGA-GD-A2C5-01A-12D-A17V-08	265135	9073469	50055514	295	33466										
MUC16	94025	broad.mit.edu	37	chr19	9083641	9083641	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcttagagggggaagtggaaGaaggatggagtggactttct	17	3	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:9083641G>C	uc002mkp.2	-	1	8378	c.8174C>G	c.(8173-8175)TCT>TGT	p.S2725C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2725	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAAGTGGAAGAAGGATGGAG	0.468													0	0	0	0.134883	0	29	119										C	9083641	G	C	9083641	3	2	109	1	0	0	0	0	1	0	0	0	9973	942	33	1	35685	1	MUC16	19	9083641	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	10172	9083641	50045342	296	33467										
DHPS	1725	broad.mit.edu	37	chr19	12790678	12790678	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	actcgcccaagtatgtgggcGccaggcacttgatgaggtct	13	11	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:12790678G>A	uc002muh.1	-	3	528	c.431C>T	c.(430-432)GCG>GTG	p.A144V	DHPS_uc002muf.1_Missense_Mutation_p.A21V|DHPS_uc002mug.1_Missense_Mutation_p.A102V|DHPS_uc002mui.1_Missense_Mutation_p.A144V|DHPS_uc002muj.1_Missense_Mutation_p.A144V|DHPS_uc002muk.1_RNA|DHPS_uc010xmn.1_RNA	NM_001930	NP_001921	P49366	DHYS_HUMAN	deoxyhypusine synthase isoform a	144					peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|post-translational protein modification|spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase|translation	cytosol	deoxyhypusine synthase activity|protein binding			central_nervous_system(1)	1					Sulfadoxine(DB01299)	GTATGTGGGCGCCAGGCACTT	0.597													0	0	0	0.144211	0	32	62										A	12790678	G	A	12790678	3	1	109	1	0	0	0	0	1	0	0	0	4485	1087	38	2	706	2	DHPS	19	12790678	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3707037	12790678	46338305	297	33468										
MAST1	22983	broad.mit.edu	37	chr19	12954349	12954349	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tggctgggttccagggcggaCggacgccggtggtctctggc	19	11	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:12954349C>T	uc002mvm.2	+	4	383	c.255C>T	c.(253-255)GAC>GAT	p.D85D	MAST1_uc002mvk.2_Silent_p.D81D|MAST1_uc002mvl.2_Intron	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	85					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CCAGGGCGGACGGACGCCGGT	0.667													0	0	0	0.038147	0	6	62										T	12954349	C	T	12954349	2	4	109	1	0	0	0	0	0	0	0	1	9324	535	19	2		2	MAST1	19	12954349	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	163671	12954349	46174634	298	33469										
CD97	976	broad.mit.edu	37	chr19	14517528	14517528	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctagctgctggttggactttGagcagggcttcctctggagc	14	10	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:14517528G>C	uc002myl.2	+	16	2188	c.2065G>C	c.(2065-2067)GAG>CAG	p.E689Q	CD97_uc002mym.2_Missense_Mutation_p.E640Q|CD97_uc002myn.2_Missense_Mutation_p.E596Q	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	689	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						GTTGGACTTTGAGCAGGGCTT	0.622											OREG0025312	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.069456	0	35	191										C	14517528	G	C	14517528	3	2	109	1	0	0	0	0	1	0	0	0	3049	1291	45	1	2127	1	CD97	19	14517528	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1563179	14517528	44611455	299	33470										
EPS15L1	58513	broad.mit.edu	37	chr19	16552747	16552747	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gccagacttctttagaaaaaGcgcagcttcactcgccccca	7	15	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:16552747G>A	uc002ndz.1	-	3	127	c.121C>T	c.(121-123)CTT>TTT	p.L41F	EPS15L1_uc002ndx.2_Missense_Mutation_p.L41F|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpf.1_5'UTR|EPS15L1_uc002nea.1_Missense_Mutation_p.L41F|EPS15L1_uc010eah.1_Missense_Mutation_p.L41F|EPS15L1_uc002nec.1_Missense_Mutation_p.L41F	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	41	EH 1.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						TTTAGAAAAAGCGCAGCTTCA	0.517											OREG0025335	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.054565	0	32	160										A	16552747	G	A	16552747	3	1	109	1	0	0	0	0	1	0	0	0	5193	971	34	2	2557	2	EPS15L1	19	16552747	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2035219	16552747	42576236	300	33471										
USHBP1	83878	broad.mit.edu	37	chr19	17373412	17373412	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atggcctccagggaggcctgCgtgcggaccagctcatcctc	13	15	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:17373412C>T	uc002nfs.1	-	4	704	c.591G>A	c.(589-591)ACG>ACA	p.T197T	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.T133T|USHBP1_uc010eam.1_Silent_p.T125T	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	197	Potential.						PDZ domain binding			ovary(1)	1						GGGAGGCCTGCGTGCGGACCA	0.657													0	0	0	0.11126	0	42	58										T	17373412	C	T	17373412	2	4	109	1	0	0	0	0	0	0	0	1	17034	755	27	2		2	USHBP1	19	17373412	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	820665	17373412	41755571	301	33472										
SLC5A5	6528	broad.mit.edu	37	chr19	17983432	17983432	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttctgaactcggtcctcaccGccctgctcttcatgcccgtc	7	18	4	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:17983432G>A	uc002nhr.3	+	1	651	c.304G>A	c.(304-306)GCC>ACC	p.A102T		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	102	Helical; (Potential).		A -> P.		cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGTCCTCACCGCCCTGCTCTT	0.662													0	0	0	0.02938	0	5	72										A	17983432	G	A	17983432	3	1	109	1	0	0	0	0	1	0	0	0	14668	1087	38	2	306	2	SLC5A5	19	17983432	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	610020	17983432	41145551	302	33473										
SLC5A5	6528	broad.mit.edu	37	chr19	17983483	17983483	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgggcctcaccagcacctacGaggtaccggacagaggcccg	13	15	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:17983483G>A	uc002nhr.3	+	1	702	c.355G>A	c.(355-357)GAG>AAG	p.E119K		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	119	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CAGCACCTACGAGGTACCGGA	0.667													0	0	0	0.02938	0	6	52										A	17983483	G	A	17983483	3	1	109	1	0	0	0	0	1	0	0	0	14668	1059	37	1	357	1	SLC5A5	19	17983483	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	51	17983483	41145500	303	33474										
NUDT19	390916	broad.mit.edu	37	chr19	33202726	33202726	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctactgaaaaaaagactgagGaaatcatgaaggaaggcaag	11	5	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:33202726G>T	uc010edf.2	+	3	991	c.991G>T	c.(991-993)GAA>TAA	p.E331*		NM_001105570	NP_001099040	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety	331						mitochondrion|peroxisome	hydrolase activity|metal ion binding				0	Esophageal squamous(110;0.137)					AAAGACTGAGGAAATCATGAA	0.348													1	0	1.58986e-06	0.069234	1.82938e-06	11	60										T	33202726	G	T	33202726	4	4	109	1	0	0	0	0	0	1	0	0	10736	1175	41	3	1001	3	NUDT19	19	33202726	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	15219243	33202726	25926257	304	33475										
ZNF30	90075	broad.mit.edu	37	chr19	35434793	35434793	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	accccttgctaagcatcagaGaattcatactggcgagaaac	8	11	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:35434793G>A	uc010edp.1	+	5	1301	c.923G>A	c.(922-924)AGA>AAA	p.R308K	ZNF30_uc002nxf.2_Missense_Mutation_p.R227K|ZNF30_uc010edq.1_Missense_Mutation_p.R309K|ZNF30_uc010edr.1_Missense_Mutation_p.R309K	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	308	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		AAGCATCAGAGAATTCATACT	0.448													0	0	0	0.049695	0	19	97										A	35434793	G	A	35434793	3	1	109	1	0	0	0	0	1	0	0	0	17827	942	33	1	940	1	ZNF30	19	35434793	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	2232067	35434793	23694190	305	33476										
RYR1	6261	broad.mit.edu	37	chr19	38966027	38966027	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acccccacgctgccccgactCcctcacgacgtggtgcctgc	9	21	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:38966027C>G	uc002oit.2	+	29	4360	c.4230C>G	c.(4228-4230)CTC>CTG	p.L1410L	RYR1_uc002oiu.2_Silent_p.L1410L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1410	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGCCCCGACTCCCTCACGACG	0.622													0	0	0	0.009096	0	4	34										G	38966027	C	G	38966027	2	3	109	1	0	0	0	0	0	0	0	1	13768	842	30	1		1	RYR1	19	38966027	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	3531234	38966027	20162956	306	33477										
DLL3	10683	broad.mit.edu	37	chr19	39995950	39995950	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgagcggggtgacatgtgcaGatggaccctgcttcaacggc	15	10	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:39995950G>C	uc002olx.2	+	6	1010	c.952G>C	c.(952-954)GAT>CAT	p.D318H	DLL3_uc010egq.2_Missense_Mutation_p.D318H|DLL3_uc002olw.2_Missense_Mutation_p.D318H	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	318	EGF-like 3.|Extracellular (Potential).				Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GACATGTGCAGATGGACCCTG	0.617													0	0	0	0.139131	0	45	104										C	39995950	G	C	39995950	3	2	109	1	0	0	0	0	1	0	0	0	4567	942	33	1	974	1	DLL3	19	39995950	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	1029923	39995950	19133033	307	33478										
ADCK4	79934	broad.mit.edu	37	chr19	41206059	41206059	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aacagctcccgcagacacagCgtcaggagctggaagcaaat	11	12	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:41206059C>T	uc002oor.2	-	12	1358	c.1056G>A	c.(1054-1056)ACG>ACA	p.T352T	ADCK4_uc002oop.1_Silent_p.T29T|ADCK4_uc002ooq.1_Silent_p.T311T	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	352	Protein kinase.					integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GCAGACACAGCGTCAGGAGCT	0.557													0	0	0	0.055883	0	21	24										T	41206059	C	T	41206059	2	4	109	1	0	0	0	0	0	0	0	1	290	755	27	2		2	ADCK4	19	41206059	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	1210109	41206059	17922924	308	33479										
CYP2A6	1548	broad.mit.edu	37	chr19	41354576	41354576	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctcctcctggatgcgctcctCgatgcctcgcttgcccaccc	8	20	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:41354576C>A	uc002opl.3	-	3	457	c.436G>T	c.(436-438)GAG>TAG	p.E146*	CYP2A6_uc010ehe.1_5'UTR|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	146					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	ATGCGCTCCTCGATGCCTCGC	0.692													1	0	4.7546e-09	0.146539	5.52832e-09	15	64										A	41354576	C	A	41354576	4	1	109	1	0	0	0	0	0	1	0	0	4162	893	31	3	1076	3	CYP2A6	19	41354576	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	148517	41354576	17774407	309	33480										
ZFP112	7771	broad.mit.edu	37	chr19	44832455	44832455	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtggactctctgatggccttGaaggtgtgaactccgactga	13	9	1	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:44832455G>C	uc010ejj.2	-	5	1986	c.1873C>G	c.(1873-1875)CAA>GAA	p.Q625E	ZFP112_uc002ozc.3_Missense_Mutation_p.Q619E|ZFP112_uc010xwy.1_Missense_Mutation_p.Q642E|ZFP112_uc010xwz.1_Missense_Mutation_p.Q624E	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	625	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TGATGGCCTTGAAGGTGTGAA	0.458													0	0	0	0.0918	0	25	171										C	44832455	G	C	44832455	3	2	109	1	0	0	0	0	1	0	0	0	17635	1299	45	1	872	1	ZFP112	19	44832455	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3477879	44832455	14296528	310	33481										
ZNF229	7772	broad.mit.edu	37	chr19	44936420	44936420	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaggattcctctcacccactGagagtaggttcctgaaattc	9	11	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:44936420G>C	uc002oze.1	-	5	649	c.215C>G	c.(214-216)TCA>TGA	p.S72*	ZNF229_uc010ejk.1_5'UTR|ZNF229_uc010ejl.1_Nonsense_Mutation_p.S72*	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	72	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				CTCACCCACTGAGAGTAGGTT	0.468													0	0	0	0.083992	0	22	144										C	44936420	G	C	44936420	4	2	109	1	0	0	0	0	0	1	0	0	17779	1294	45	1	2270	1	ZNF229	19	44936420	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	103965	44936420	14192563	311	33482										
FKRP	79147	broad.mit.edu	37	chr19	47259808	47259808	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tacgacgtggacctgggcatCtacttggaggacgtgggcaa	15	9	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:47259808C>G	uc002pfn.2	+	4	1398	c.1101C>G	c.(1099-1101)ATC>ATG	p.I367M	FKRP_uc002pfp.2_Missense_Mutation_p.I367M	NM_024301	NP_077277	Q9H9S5	FKRP_HUMAN	fukutin-related protein	367						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			pancreas(1)	1		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		ACCTGGGCATCTACTTGGAGG	0.701													0	0	0	0.02938	0	7	25										G	47259808	C	G	47259808	3	3	109	1	0	0	0	0	1	0	0	0	5917	903	32	1	1103	1	FKRP	19	47259808	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2323388	47259808	11869175	312	33483										
NUCB1	4924	broad.mit.edu	37	chr19	49425626	49425626	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccagaaggaggtggacacttCagaaaagaaacttctcgagc	11	9	2	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:49425626C>G	uc002plb.3	+	13	1403	c.1331C>G	c.(1330-1332)TCA>TGA	p.S444*	NUCB1_uc002plc.2_Nonsense_Mutation_p.S444*|NUCB1_uc002pld.2_Nonsense_Mutation_p.S107*	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	444						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		GTGGACACTTCAGAAAAGAAA	0.547													0	0	0	0.139131	0	42	92										G	49425626	C	G	49425626	4	3	109	1	0	0	0	0	0	1	0	0	10718	838	29	1	1377	1	NUCB1	19	49425626	Nonsense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	2165818	49425626	9703357	313	33484										
ZNF28	7576	broad.mit.edu	37	chr19	53303586	53303586	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtaaggcatgaatcactccgGaaagccttgtcacaaacctt	8	11	2	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:53303586G>A	uc002qad.2	-	4	1632	c.1512C>T	c.(1510-1512)TTC>TTT	p.F504F	ZNF28_uc002qac.2_Silent_p.F451F|ZNF28_uc010eqe.2_Silent_p.F450F	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	504	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		AATCACTCCGGAAAGCCTTGT	0.393													0	0	0	0.054565	0	30	161										A	53303586	G	A	53303586	2	1	109	1	0	0	0	0	0	0	0	1	17810	1165	41	1		1	ZNF28	19	53303586	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	3877960	53303586	5825397	314	33485										
ZNF671	79891	broad.mit.edu	37	chr19	58238866	58238866	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cttccgtccctgcagagcatCagacgcgtctcgggacactg	11	15	2	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr19:58238866C>G	uc002qpz.3	-	1	130	c.31G>C	c.(31-33)GAT>CAT	p.D11H	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_5'UTR|ZNF671_uc010yhf.1_5'UTR	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGCAGAGCATCAGACGCGTCT	0.667													0	0	0	0.038147	0	8	41										G	58238866	C	G	58238866	3	3	109	1	0	0	0	0	1	0	0	0	18075	826	29	1	1589	1	ZNF671	19	58238866	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4935280	58238866	890117	315	33486										
MCM8	84515	broad.mit.edu	37	chr20	5937805	5937805	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	accttgaaaggcatgcagctGagttacaagcccaggaagga	12	9	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:5937805G>C	uc002wmi.2	+	6	897	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	MCM8_uc002wmj.2_Missense_Mutation_p.E174Q|MCM8_uc002wmk.2_Missense_Mutation_p.E174Q|MCM8_uc002wml.2_Missense_Mutation_p.E174Q|MCM8_uc010gbp.2_Missense_Mutation_p.E174Q	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	174					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						GCATGCAGCTGAGTTACAAGC	0.368													0	0	0	0.038147	0	6	42										C	5937805	G	C	5937805	3	2	109	1	0	0	0	0	1	0	0	0	9393	1291	45	1	538	1	MCM8	20	5937805	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		5937805	57087715	316	33487										
MCM8	84515	broad.mit.edu	37	chr20	5937835	5937835	+	Missense_Mutation	SNP	G	G	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cccaggaaggattgtctaatGatggagaaacaatggtaaat							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:5937835G>A	uc002wmi.2	+	6	927	c.550G>A	c.(550-552)GAT>AAT	p.D184N	MCM8_uc002wmj.2_Missense_Mutation_p.D184N|MCM8_uc002wmk.2_Missense_Mutation_p.D184N|MCM8_uc002wml.2_Missense_Mutation_p.D184N|MCM8_uc010gbp.2_Missense_Mutation_p.D184N	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	184					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						ATTGTCTAATGATGGAGAAAC	0.383													0	0	0	0.038147	0	6	36										A	5937835	G	A	5937835	3	1	109	1	0	0	0	0	1	0	0	0	9393	1290	45	1	568	1	MCM8	20	5937835	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	30	5937835	57087685	317	33488	169	2								
MCM8	84515	broad.mit.edu	37	chr20	5937839	5937839	+	Missense_Mutation	SNP	G	G	A													0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggaaggattgtctaatgatgGagaaacaatggtaaatgtgc							TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:5937839G>A	uc002wmi.2	+	6	931	c.554G>A	c.(553-555)GGA>GAA	p.G185E	MCM8_uc002wmj.2_Missense_Mutation_p.G185E|MCM8_uc002wmk.2_Missense_Mutation_p.G185E|MCM8_uc002wml.2_Missense_Mutation_p.G185E|MCM8_uc010gbp.2_Missense_Mutation_p.G185E	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	185					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						TCTAATGATGGAGAAACAATG	0.383													0	0	0	0.02938	0	5	37										A	5937839	G	A	5937839	3	1	109	1	0	0	0	0	1	0	0	0	9393	1174	41	1	572	1	MCM8	20	5937839	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	4	5937839	57087681	318	33489	169	2								
RBBP9	10741	broad.mit.edu	37	chr20	18474623	18474623	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tcatggccgcgatggccccaGaactgtggccaatgatgata	12	11	1	3			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:18474623G>A	uc002wqy.2	-	3	303	c.227C>T	c.(226-228)TCT>TTT	p.S76F		NM_006606	NP_006597	O75884	RBBP9_HUMAN	retinoblastoma binding protein 9	76						cytoplasm|nucleus	hydrolase activity			haematopoietic_and_lymphoid_tissue(1)	1						GATGGCCCCAGAACTGTGGCC	0.493													0	0	0	0.083992	0	23	125										A	18474623	G	A	18474623	3	1	109	1	0	0	0	0	1	0	0	0	13106	942	33	1	345	1	RBBP9	20	18474623	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	12536784	18474623	44550897	319	33490										
SPAG4	6676	broad.mit.edu	37	chr20	34206013	34206013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ccctctctttctccagcattCtggctggggcttctgtacct	8	15	4	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:34206013C>G	uc002xdb.1	+	5	660	c.543C>G	c.(541-543)TTC>TTG	p.F181L	SPAG4_uc010zvi.1_Missense_Mutation_p.F104L	NM_003116	NP_003107	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	181	Helical; (Potential).				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity				0	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			CTCCAGCATTCTGGCTGGGGC	0.557													0	0	0	0.108266	0	23	105										G	34206013	C	G	34206013	3	3	109	1	0	0	0	0	1	0	0	0	14980	912	32	1	561	1	SPAG4	20	34206013	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	15731390	34206013	28819507	320	33491										
BCAS1	8537	broad.mit.edu	37	chr20	52645063	52645063	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgtcccttgtccagcttgaaGaatttgtcaaaaaagctgga	9	8	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:52645063G>A	uc002xws.2	-	4	929	c.591C>T	c.(589-591)TTC>TTT	p.F197F	BCAS1_uc010zzb.1_Silent_p.F100F|BCAS1_uc010gim.2_Silent_p.F100F|BCAS1_uc002xwt.2_Silent_p.F197F|BCAS1_uc010gil.1_Silent_p.F197F|BCAS1_uc010zzc.1_Silent_p.F100F	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	197						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCAGCTTGAAGAATTTGTCAA	0.557													0	0	0	0.059317	0	33	205										A	52645063	G	A	52645063	2	1	109	1	0	0	0	0	0	0	0	1	1350	933	33	1		1	BCAS1	20	52645063	Silent	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	18439050	52645063	10380457	321	33492										
BCAS1	8537	broad.mit.edu	37	chr20	52645101	52645101	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggagtccttgggcttggaggGagcttctcctcctgctcccc	13	14	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:52645101G>A	uc002xws.2	-	4	891	c.553C>T	c.(553-555)CCC>TCC	p.P185S	BCAS1_uc010zzb.1_Missense_Mutation_p.P88S|BCAS1_uc010gim.2_Missense_Mutation_p.P88S|BCAS1_uc002xwt.2_Missense_Mutation_p.P185S|BCAS1_uc010gil.1_Missense_Mutation_p.P185S|BCAS1_uc010zzc.1_Missense_Mutation_p.P88S	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	185						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GGCTTGGAGGGAGCTTCTCCT	0.592													0	0	0	0.069288	0	24	154										A	52645101	G	A	52645101	3	1	109	1	0	0	0	0	1	0	0	0	1350	1174	41	1	1237	1	BCAS1	20	52645101	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	38	52645101	10380419	322	33493										
DIDO1	11083	broad.mit.edu	37	chr20	61537316	61537316	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aattgtgatcgctcgcccacGacggcgtgctgctctcacaa	10	14	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr20:61537316G>A	uc002ydr.1	-	6	1775	c.1511C>T	c.(1510-1512)TCG>TTG	p.S504L	DIDO1_uc002yds.1_Missense_Mutation_p.S504L|DIDO1_uc002ydt.1_Missense_Mutation_p.S504L|DIDO1_uc002ydu.1_Missense_Mutation_p.S504L|DIDO1_uc002ydv.1_Missense_Mutation_p.S504L|DIDO1_uc002ydw.1_Missense_Mutation_p.S504L|DIDO1_uc002ydx.1_Missense_Mutation_p.S504L|DIDO1_uc011aao.1_Missense_Mutation_p.S504L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	504					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					GCTCGCCCACGACGGCGTGCT	0.532													0	0	0	0.069234	0	10	203										A	61537316	G	A	61537316	3	1	109	1	0	0	0	0	1	0	0	0	4522	1059	37	1	5385	1	DIDO1	20	61537316	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	8892215	61537316	1488204	323	33494										
NRIP1	8204	broad.mit.edu	37	chr21	16337172	16337172	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aaattaaagaaagaagctttCgtttctgcagtaggaagtaa	9	4	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr21:16337172C>T	uc002yjx.2	-	4	3940	c.3342G>A	c.(3340-3342)ACG>ACA	p.T1114T		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	1114					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AAGAAGCTTTCGTTTCTGCAG	0.438													0	0	0	0.139131	0	53	85										T	16337172	C	T	16337172	2	4	109	1	0	0	0	0	0	0	0	1	10652	871	31	1		1	NRIP1	21	16337172	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		16337172	31792723	324	33495										
GABPA	2551	broad.mit.edu	37	chr21	27137078	27137078	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	aagcctacgatgaactatgaGaaactcagtcgtgcattaag	9	8	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr21:27137078G>C	uc002ylx.3	+	9	1643	c.1116G>C	c.(1114-1116)GAG>GAC	p.E372D	GABPA_uc002yly.3_Missense_Mutation_p.E372D	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	372	ETS.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						TGAACTATGAGAAACTCAGTC	0.333													0	0	0	0.047766	0	9	50										C	27137078	G	C	27137078	3	2	109	1	0	0	0	0	1	0	0	0	6157	933	33	1	1146	1	GABPA	21	27137078	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	10799906	27137078	20992817	325	33496										
KRTAP19-5	337972	broad.mit.edu	37	chr21	31874326	31874326	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtctgcggaagctgccacatCcacagccatagccatagccc	9	16	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr21:31874326C>T	uc011ada.1	-	1	83	c.83G>A	c.(82-84)GGA>GAA	p.G28E		NM_181611	NP_853642	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	28						intermediate filament	protein binding				0						GCTGCCACATCCACAGCCATA	0.597													0	0	0	0.139131	0	92	147										T	31874326	C	T	31874326	3	4	109	1	0	0	0	0	1	0	0	0	8532	855	30	1	138	1	KRTAP19-5	21	31874326	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	4737248	31874326	16255569	326	33497										
CRYAA	1409	broad.mit.edu	37	chr21	44592274	44592274	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tctcttgctccctgtctgccGatggcatgctgaccttctgt	9	14	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr21:44592274G>T	uc002zdd.1	+	3	475	c.406G>T	c.(406-408)GAT>TAT	p.D136Y		NM_000394	NP_000385	P02489	CRYAA_HUMAN	crystallin, alpha A	136					anti-apoptosis|negative regulation of intracellular transport|protein homooligomerization|response to heat|visual perception	cytoplasm|nucleus	structural constituent of eye lens|unfolded protein binding			breast(1)|central_nervous_system(1)	2						CCTGTCTGCCGATGGCATGCT	0.657													1	0	0.000422831	0.146539	0.000482769	17	74										T	44592274	G	T	44592274	3	4	109	1	0	0	0	0	1	0	0	0	3905	1058	37	3	416	3	CRYAA	21	44592274	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	12717948	44592274	3537621	327	33498										
PDXK	8566	broad.mit.edu	37	chr21	45161560	45161560	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gcctctaggctatgcccactGgaagggccaagtgctgaatt	12	11	1	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr21:45161560G>A	uc002zdm.3	+	3	353	c.155G>A	c.(154-156)TGG>TAG	p.W52*	PDXK_uc010gpj.2_Nonsense_Mutation_p.W52*|PDXK_uc002zdn.3_Nonsense_Mutation_p.W52*|PDXK_uc002zdq.3_Intron	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	52					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	TATGCCCACTGGAAGGGCCAA	0.577													0	0	0	0.021553	0	5	83										A	45161560	G	A	45161560	4	1	109	1	0	0	0	0	0	1	0	0	11697	1357	47	2	165	2	PDXK	21	45161560	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	569286	45161560	2968335	328	33499										
COMT	1312	broad.mit.edu	37	chr22	19951777	19951777	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	acactggacatggtcttcctCgaccactggaaggaccggta	11	12	1	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr22:19951777C>G	uc002zqu.2	+	5	819	c.570C>G	c.(568-570)CTC>CTG	p.L190L	COMT_uc002zqt.2_Silent_p.L190L|COMT_uc002zqv.2_Silent_p.L190L|COMT_uc002zqw.2_Silent_p.L190L|COMT_uc011ahd.1_Silent_p.L190L|COMT_uc002zqx.2_Silent_p.L190L	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	190					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	TGGTCTTCCTCGACCACTGGA	0.592													0	0	0	0.134883	0	31	70										G	19951777	C	G	19951777	2	3	109	1	0	0	0	0	0	0	0	1	3725	871	31	1		1	COMT	22	19951777	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08		19951777	31352789	329	33500										
SEZ6L	23544	broad.mit.edu	37	chr22	26761376	26761376	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gtgacaacccagggctgcctGaaaatggataccaaatcctg	10	11	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr22:26761376G>T	uc003acb.2	+	13	2794	c.2638G>T	c.(2638-2640)GAA>TAA	p.E880*	SEZ6L_uc003acc.2_Nonsense_Mutation_p.E880*|SEZ6L_uc011akc.1_Nonsense_Mutation_p.E880*|SEZ6L_uc003acd.2_Nonsense_Mutation_p.E816*|SEZ6L_uc011akd.1_Nonsense_Mutation_p.E880*|SEZ6L_uc003ace.2_Intron|SEZ6L_uc003acf.1_Nonsense_Mutation_p.E653*|SEZ6L_uc010gvc.1_Intron|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	880	Sushi 5.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						AGGGCTGCCTGAAAATGGATA	0.522													1	0	1.50986e-39	0.139131	1.81266e-39	100	128										T	26761376	G	T	26761376	4	4	109	1	0	0	0	0	0	1	0	0	14143	1291	45	3	2688	3	SEZ6L	22	26761376	Nonsense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6809599	26761376	24543190	330	33501										
CARD10	29775	broad.mit.edu	37	chr22	37898637	37898637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	gaagtccaggccacagccccGagccaggaggccttccggct	13	16	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr22:37898637G>A	uc003asx.1	-	11	1762	c.1759C>T	c.(1759-1761)CGG>TGG	p.R587W	CARD10_uc003ast.1_RNA|CARD10_uc003asw.1_Missense_Mutation_p.R301W|CARD10_uc003asy.1_Missense_Mutation_p.R587W	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	587					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					CCACAGCCCCGAGCCAGGAGG	0.617													0	0	0	0.105934	0	13	41										A	37898637	G	A	37898637	3	1	109	1	0	0	0	0	1	0	0	0	2644	1057	37	1	1379	1	CARD10	22	37898637	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	11137261	37898637	13405929	331	33502										
TRIOBP	11078	broad.mit.edu	37	chr22	38155170	38155170	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctccctcgtaggttcaggctCttcgggcccagctggaggcg	14	14	2	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr22:38155170C>T	uc003atr.2	+	17	6494	c.6223C>T	c.(6223-6225)CTT>TTT	p.L2075F	TRIOBP_uc003atu.2_Missense_Mutation_p.L1903F|TRIOBP_uc003atv.2_Missense_Mutation_p.L362F|TRIOBP_uc003atw.2_Missense_Mutation_p.L362F|TRIOBP_uc003atx.1_5'UTR|TRIOBP_uc010gxh.2_5'UTR	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	2075	Potential.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GGTTCAGGCTCTTCGGGCCCA	0.652													0	0	0	0.021553	0	5	28										T	38155170	C	T	38155170	3	4	109	1	0	0	0	0	1	0	0	0	16550	913	32	1	6468	1	TRIOBP	22	38155170	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	256533	38155170	13149396	332	33503										
TBC1D22A	25771	broad.mit.edu	37	chr22	47507475	47507475	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ctcgtgagatggaggaaggaAatactagaagaaaaagattt	12	3	0	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chr22:47507475A>C	uc003bib.2	+	12	1536	c.1401A>C	c.(1399-1401)GAA>GAC	p.E467D	TBC1D22A_uc010haf.2_Missense_Mutation_p.E437D|TBC1D22A_uc003bic.2_Missense_Mutation_p.E408D|TBC1D22A_uc003bie.2_Missense_Mutation_p.E389D|TBC1D22A_uc003bid.2_RNA|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.E420D	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	467						intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGAGGAAGGAAATACTAGAAG	0.358													0	0	0	0.105934	0	12	43										C	47507475	A	C	47507475	3	2	109	1	0	0	0	0	1	0	0	0	15608	11	1	5	1447	5	TBC1D22A	22	47507475	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	9352305	47507475	3797091	333	33504										
SCML2	10389	broad.mit.edu	37	chrX	18283889	18283889	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggcttgcttcggaaggagaaGactctgtttttgctatattc	11	7	1	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:18283889G>A	uc004cyl.2	-	8	921	c.764C>T	c.(763-765)TCT>TTT	p.S255F	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.S255F|SCML2_uc011miz.1_Missense_Mutation_p.S189F|SCML2_uc010nfc.2_5'UTR	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	255					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					GGAAGGAGAAGACTCTGTTTT	0.363													0	0	0	0.069288	0	24	26										A	18283889	G	A	18283889	3	1	109	1	0	0	0	0	1	0	0	0	13910	942	33	1	1370	1	SCML2	23	18283889	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08		18283889	136986671	334	33505										
RPGR	6103	broad.mit.edu	37	chrX	38147258	38147258	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	atcatcgttttcagtaagagCtgtatcctgcgtcagttccc	8	11	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:38147258C>T	uc004ded.1	-	14	1777	c.1609G>A	c.(1609-1611)GCT>ACT	p.A537T	RPGR_uc004deb.2_Missense_Mutation_p.A537T|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	537	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCAGTAAGAGCTGTATCCTGC	0.338													0	0	0	0.069288	0	23	52										T	38147258	C	T	38147258	3	4	109	1	0	0	0	0	1	0	0	0	13548	797	28	2	2416	2	RPGR	23	38147258	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	19863369	38147258	117123302	335	33506										
KDM6A	7403	broad.mit.edu	37	chrX	44966654	44966654	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ataatttctcccccacaataGgtattgtcttctaagaactc	4	11	3	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:44966654G>A	uc004dge.3	+	27	4254	c.3879_splice	c.e27-1	p.K1293_splice	KDM6A_uc011mkz.1_Splice_Site_p.K1345_splice|KDM6A_uc011mla.1_Splice_Site_p.K1248_splice|KDM6A_uc011mlb.1_Splice_Site_p.K1300_splice|KDM6A_uc011mlc.1_Splice_Site_p.K997_splice|KDM6A_uc011mld.1_Splice_Site_p.K932_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						CCCCACAATAGGTATTGTCTT	0.368			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.069288	0	22	21										A	44966654	G	A	44966654	5	1	109	1	0	0	0	0	0	0	1	0	8137	1014	35	2	3984	2	KDM6A	23	44966654	Splice_Site	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	6819396	44966654	110303906	336	33507										
IGBP1	3476	broad.mit.edu	37	chrX	69353901	69353901	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ggcgactgaacccgccggttCccggatagtccaggagaagg	15	12	0	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:69353901C>T	uc004dxv.2	+	1	603	c.104C>T	c.(103-105)TCC>TTC	p.S35F	IGBP1_uc004dxw.2_Missense_Mutation_p.S35F	NM_001551	NP_001542	P78318	IGBP1_HUMAN	immunoglobulin binding protein 1	35					B cell activation|negative regulation of caspase activity|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|regulation of microtubule-based movement|response to interleukin-1|response to tumor necrosis factor|signal transduction	cytoplasm	protein phosphatase type 2A regulator activity			kidney(1)|pancreas(1)	2						CCCGCCGGTTCCCGGATAGTC	0.562											OREG0019849	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.043863	0	14	39										T	69353901	C	T	69353901	3	4	109	1	0	0	0	0	1	0	0	0	7567	855	30	1	106	1	IGBP1	23	69353901	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	24387247	69353901	85916659	337	33508										
MED12	9968	broad.mit.edu	37	chrX	70356862	70356862	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cataggcctgtacacccagaAccagccactacctgcaggtg	9	15	0	1			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:70356862A>C	uc004dyy.2	+	38	5733	c.5534A>C	c.(5533-5535)AAC>ACC	p.N1845T	MED12_uc011mpq.1_Missense_Mutation_p.N1845T|MED12_uc004dyz.2_Missense_Mutation_p.N1845T|MED12_uc004dza.2_Missense_Mutation_p.N1692T|MED12_uc010nla.2_Missense_Mutation_p.N471T	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1845	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TACACCCAGAACCAGCCACTA	0.567													0	0	0	0.080935	0	4	17										C	70356862	A	C	70356862	3	2	109	1	0	0	0	0	1	0	0	0	9428	43	2	5	5684	5	MED12	23	70356862	Missense_Mutation	SNP	A	TCGA-GD-A2C5-01A-12D-A17V-08	1002961	70356862	84913698	338	33509										
RBM41	55285	broad.mit.edu	37	chrX	106359927	106359927	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	tgatgctgaaggaggcttttCagctgcctctccccttctgt	10	12	3	2			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:106359927C>T	uc004emz.2	-	2	109	c.78G>A	c.(76-78)CTG>CTA	p.L26L	RBM41_uc004emy.1_Silent_p.L26L	NM_018301	NP_060771	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	26							nucleotide binding|RNA binding			ovary(1)	1						GGAGGCTTTTCAGCTGCCTCT	0.443													0	0	0	0.055883	0	18	42										T	106359927	C	T	106359927	2	4	109	1	0	0	0	0	0	0	0	1	13135	813	29	1		1	RBM41	23	106359927	Silent	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	36003065	106359927	48910633	339	33510										
PGRMC1	10857	broad.mit.edu	37	chrX	118374364	118374364	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	cactgaaggatgagtacgatGacctttctgacctcactgct	9	11	2	4			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:118374364G>A	uc004erb.2	+	2	537	c.421G>A	c.(421-423)GAC>AAC	p.D141N	PGRMC1_uc011mts.1_Intron	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	141	Cytochrome b5 heme-binding.|Cytoplasmic (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						TGAGTACGATGACCTTTCTGA	0.483													0	0	0	0.125774	0	29	97										A	118374364	G	A	118374364	3	1	109	1	0	0	0	0	1	0	0	0	11806	1290	45	1	427	1	PGRMC1	23	118374364	Missense_Mutation	SNP	G	TCGA-GD-A2C5-01A-12D-A17V-08	12014437	118374364	36896196	340	33511										
GPR101	83550	broad.mit.edu	37	chrX	136112888	136112888	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.448071216617211	151	3.2032044685311e-52	3.86417978486401	5.28300926103831	2.98467145460392	0.499285501071854	0.689830814103477	112	ttccttaccctccatgctgcCgtcgctggccaccgtgctgc	9	18	0	0			TCGA-GD-A2C5-01A-12D-A17V-08	TCGA-GD-A2C5-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2b142863-b963-4cc9-8f8f-c72503c93390	60e4591c-6ce7-4a65-8355-653f5c41cd2e	g.chrX:136112888C>T	uc011mwh.1	-	1	946	c.946G>A	c.(946-948)GGC>AGC	p.G316S		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					TCCATGCTGCCGTCGCTGGCC	0.597													0	0	0	0.074837	0	39	283										T	136112888	C	T	136112888	3	4	109	1	0	0	0	0	1	0	0	0	6622	652	23	2	583	2	GPR101	23	136112888	Missense_Mutation	SNP	C	TCGA-GD-A2C5-01A-12D-A17V-08	17738524	136112888	19157672	341	33512										
RNF207	388591	broad.mit.edu	37	chr1	6270478	6270478	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcagcttggccaacaaggctGagttcctggacctgggctat	12	11	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:6270478G>C	uc001amg.2	+	10	1096	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	RNF207_uc001amh.2_Nonstop_Mutation_p.*196S|RNF207_uc010nzp.1_RNA	NM_207396	NP_997279	Q6ZRF8	RN207_HUMAN	ring finger protein 207	308						intracellular	zinc ion binding				0	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CAACAAGGCTGAGTTCCTGGA	0.647													0	0	0	0.00308	0	6	109										C	6270478	G	C	6270478	3	2	110	1	0	0	0	0	1	0	0	0	13474	1291	45	1	956	1	RNF207	1	6270478	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		6270478	242980143	1	33513										
APITD1	378708	broad.mit.edu	37	chr1	10500432	10500432	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaagaaccacaattaacactGaagatgtgaagctcttagcc	7	9	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:10500432G>A	uc001are.2	+	4	654	c.238G>A	c.(238-240)GAA>AAA	p.E80K	APITD1_uc001arf.2_Missense_Mutation_p.E80K|APITD1_uc001arg.2_Intron|APITD1_uc001arh.2_Missense_Mutation_p.E41K	NM_199294	NP_954988	Q8N2Z9	CENPS_HUMAN	apoptosis-inducing, TAF9-like domain 1 isoform	80					DNA repair|mitotic prometaphase|transcription initiation, DNA-dependent	chromosome, centromeric region|cytosol|Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AATTAACACTGAAGATGTGAA	0.393													0	0	0	0.001984	0	4	65										A	10500432	G	A	10500432	3	1	110	1	0	0	0	0	1	0	0	0	775	1291	45	1	252	1	APITD1	1	10500432	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4229954	10500432	238750189	2	33514										
FBXO2	26232	broad.mit.edu	37	chr1	11708827	11708827	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agtagacggagtcctgccccCcgtgctcgaagcggacgaag	14	13	0	1	rs149264736		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:11708827C>G	uc001asj.2	-	6	1157	c.815G>C	c.(814-816)GGG>GCG	p.G272A	FBXO2_uc009vna.2_Missense_Mutation_p.G275A	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	272	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		GTCCTGCCCCCCGTGCTCGAA	0.667													0	0	0	0.000978	0	9	127										G	11708827	C	G	11708827	3	3	110	1	0	0	0	0	1	0	0	0	5732	623	22	4	79	4	FBXO2	1	11708827	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1208395	11708827	237541794	3	33515										
TMEM82	388595	broad.mit.edu	37	chr1	16074093	16074093	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	accaagccagcccctgccctCggcaccccagtcccagagtt	8	20	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:16074093C>T	uc001axc.2	+	6	1136	c.998C>T	c.(997-999)TCG>TTG	p.S333L		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	333						integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCTGCCCTCGGCACCCCAG	0.607													0	0	0	0.000602	0	5	134										T	16074093	C	T	16074093	3	4	110	1	0	0	0	0	1	0	0	0	16203	893	31	1	1020	1	TMEM82	1	16074093	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4365266	16074093	233176528	4	33516										
CROCC	9696	broad.mit.edu	37	chr1	17265447	17265447	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cggcgtccagctgagcggctCtgagcgcaccgcggatgctt	15	14	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:17265447C>G	uc001azt.2	+	12	1487	c.1418C>G	c.(1417-1419)TCT>TGT	p.S473C	CROCC_uc009voy.1_Missense_Mutation_p.S176C|CROCC_uc009voz.1_Missense_Mutation_p.S236C|CROCC_uc001azu.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	473					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CTGAGCGGCTCTGAGCGCACC	0.711													0	0	0	0.008291	0	6	109										G	17265447	C	G	17265447	3	3	110	1	0	0	0	0	1	0	0	0	3893	913	32	1	1464	1	CROCC	1	17265447	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1191354	17265447	231985174	5	33517										
PADI2	11240	broad.mit.edu	37	chr1	17410286	17410286	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagctcacagttggttttctCcacaaggttcttcacctctt	6	13	5	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:17410286C>G	uc001baf.2	-	9	1067	c.985G>C	c.(985-987)GAG>CAG	p.E329Q	PADI2_uc010ocm.1_Missense_Mutation_p.E213Q|PADI2_uc001bag.1_Missense_Mutation_p.E329Q	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	329					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TTGGTTTTCTCCACAAGGTTC	0.542													0	0	0	0.001855	0	11	124										G	17410286	C	G	17410286	3	3	110	1	0	0	0	0	1	0	0	0	11378	864	30	1	1044	1	PADI2	1	17410286	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	144839	17410286	231840335	6	33518										
TMEM57	55219	broad.mit.edu	37	chr1	25824881	25824881	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gagccctgtttccccccactActcttccaaatttgtggaga	7	14	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:25824881A>G	uc001bkk.2	+	11	2121	c.1919A>G	c.(1918-1920)TAC>TGC	p.Y640C	TMEM57_uc009vru.2_Missense_Mutation_p.Y413C|TMEM57_uc009vrv.2_Missense_Mutation_p.Y282C	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	640						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCCCCACTACTCTTCCAAA	0.542													0	0	0	0.007413	0	16	147										G	25824881	A	G	25824881	3	3	110	1	0	0	0	0	1	0	0	0	16181	391	14	5	1961	5	TMEM57	1	25824881	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	8414595	25824881	223425740	7	33519										
RCC1	1104	broad.mit.edu	37	chr1	28863401	28863401	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcctctgtggggtatgctgtGaccaaggatggtgagtgggg	19	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:28863401G>A	uc001bqg.1	+	9	1165	c.1080G>A	c.(1078-1080)GTG>GTA	p.V360V	SNHG3-RCC1_uc001bqa.1_Silent_p.V360V|SNHG3-RCC1_uc001bqb.1_Silent_p.V360V|SNHG3-RCC1_uc001bqc.1_Silent_p.V360V|RCC1_uc001bqe.1_Silent_p.V377V|RCC1_uc001bqf.1_Silent_p.V391V	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	360	RCC1 6.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GGTATGCTGTGACCAAGGATG	0.587													0	0	0	0.00333	0	21	344										A	28863401	G	A	28863401	2	1	110	1	0	0	0	0	0	0	0	1	13173	1277	45	1		1	RCC1	1	28863401	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3038520	28863401	220387220	8	33520										
INPP5B	3633	broad.mit.edu	37	chr1	38397639	38397639	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tagggccgagttacaaccgcGcggcgttggcatctccagct	13	13	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:38397639G>A	uc001ccg.1	-	7	572	c.478C>T	c.(478-480)CGC>TGC	p.R160C	INPP5B_uc009vvk.1_Missense_Mutation_p.R101C|INPP5B_uc001cch.2_Missense_Mutation_p.R101C|INPP5B_uc001ccf.1_5'Flank	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	160					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTACAACCGCGCGGCGTTGGC	0.612													0	0	0	0.000602	0	5	101										A	38397639	G	A	38397639	3	1	110	1	0	0	0	0	1	0	0	0	7755	1087	38	2	2335	2	INPP5B	1	38397639	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9534238	38397639	210852982	9	33521										
MFSD2A	84879	broad.mit.edu	37	chr1	40432551	40432551	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tacggctggtcatgagccacGgcccatacatcaaacttatt	8	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:40432551G>A	uc001cev.2	+	8	1094	c.913G>A	c.(913-915)GGC>AGC	p.G305S	MFSD2A_uc010ojb.1_Missense_Mutation_p.G253S|MFSD2A_uc001ceu.2_Missense_Mutation_p.G292S|MFSD2A_uc010ojc.1_Missense_Mutation_p.G136S|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_5'Flank	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	305					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2						CATGAGCCACGGCCCATACAT	0.562													0	0	0	0.00245	0	12	188										A	40432551	G	A	40432551	3	1	110	1	0	0	0	0	1	0	0	0	9530	1116	39	2	943	2	MFSD2A	1	40432551	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2034912	40432551	208818070	10	33522										
CAP1	10487	broad.mit.edu	37	chr1	40536608	40536608	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgaaatagtcagtgccaaatCttccgagatgaatgtcctca	8	9	3	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:40536608C>T	uc001cfa.3	+	12	1530	c.1301C>T	c.(1300-1302)TCT>TTT	p.S434F	CAP1_uc001cey.3_Missense_Mutation_p.S434F|CAP1_uc001cez.3_Missense_Mutation_p.S434F|CAP1_uc009vvz.2_Missense_Mutation_p.S434F|CAP1_uc010oje.1_Missense_Mutation_p.S351F	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	434	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGTGCCAAATCTTCCGAGATG	0.408													0	0	0	0.001368	0	10	179										T	40536608	C	T	40536608	3	4	110	1	0	0	0	0	1	0	0	0	2619	913	32	1	1343	1	CAP1	1	40536608	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	104057	40536608	208714013	11	33523										
ZNF643	65243	broad.mit.edu	37	chr1	40928137	40928137	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagagtcagccttacagaatGatatttcgtgggaagaacta	10	6	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:40928137G>C	uc001cfn.1	+	5	778	c.481G>C	c.(481-483)GAT>CAT	p.D161H	ZNF643_uc001cfl.1_Missense_Mutation_p.D59H|ZNF643_uc001cfm.1_Missense_Mutation_p.D27H	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			CTTACAGAATGATATTTCGTG	0.323													0	0	0	0.003163	0	15	162										C	40928137	G	C	40928137	3	2	110	1	0	0	0	0	1	0	0	0	18056	1290	45	1	499	1	ZNF643	1	40928137	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	391529	40928137	208322484	12	33524										
B4GALT2	8704	broad.mit.edu	37	chr1	44450629	44450629	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcctatgactgcttcatcttCagcgatgtggacctggtccc	10	13	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:44450629C>T	uc001clg.2	+	4	1012	c.642C>T	c.(640-642)TTC>TTT	p.F214F	B4GALT2_uc001clh.2_Silent_p.F148F|B4GALT2_uc010okl.1_Silent_p.F243F|B4GALT2_uc001cli.2_Silent_p.F214F	NM_003780	NP_003771	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	214	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GCTTCATCTTCAGCGATGTGG	0.587													0	0	0	0.001168	0	5	108										T	44450629	C	T	44450629	2	4	110	1	0	0	0	0	0	0	0	1	1271	825	29	1		1	B4GALT2	1	44450629	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3522492	44450629	204799992	13	33525										
AKR1A1	10327	broad.mit.edu	37	chr1	46027485	46027485	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caatggcggcttcctgtgttCtactgcacactgggcagaag	12	11	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:46027485C>T	uc001cod.2	+	3	483	c.19C>T	c.(19-21)CTA>TTA	p.L7L	AKR1A1_uc009vxw.2_Silent_p.L7L|AKR1A1_uc001coe.2_Silent_p.L7L	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	7					glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TTCCTGTGTTCTACTGCACAC	0.502													0	0	0	0.003163	0	10	129										T	46027485	C	T	46027485	2	4	110	1	0	0	0	0	0	0	0	1	465	912	32	1		1	AKR1A1	1	46027485	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1576856	46027485	203223136	14	33526										
POMGNT1	55624	broad.mit.edu	37	chr1	46661728	46661728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atggatgccccggccctgctCccgggcctcatcctccagca	10	19	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:46661728C>T	uc001cpe.2	-	5	540	c.376G>A	c.(376-378)GAG>AAG	p.E126K	POMGNT1_uc010olx.1_Missense_Mutation_p.E104K|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_5'UTR|POMGNT1_uc001cpg.2_Missense_Mutation_p.E126K|POMGNT1_uc001cpf.2_5'UTR|POMGNT1_uc001cpj.2_Missense_Mutation_p.E110K	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	126	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CGGCCCTGCTCCCGGGCCTCA	0.572													0	0	0	0.001168	0	6	90										T	46661728	C	T	46661728	3	4	110	1	0	0	0	0	1	0	0	0	12243	864	30	1	1678	1	POMGNT1	1	46661728	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	634243	46661728	202588893	15	33527										
LRRC41	10489	broad.mit.edu	37	chr1	46744891	46744891	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gagagaggaggatgaatcctCtgagaaaacatctgccaagg	13	7	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:46744891C>T	uc001cpn.2	-	9	2226	c.2182G>A	c.(2182-2184)GAG>AAG	p.E728K	LRRC41_uc010omb.1_3'UTR	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	728	LRR 6.									ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					GATGAATCCTCTGAGAAAACA	0.542													0	0	0	0.00308	0	6	44										T	46744891	C	T	46744891	3	4	110	1	0	0	0	0	1	0	0	0	8999	922	32	1	264	1	LRRC41	1	46744891	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	83163	46744891	202505730	16	33528										
DMRTB1	63948	broad.mit.edu	37	chr1	53927289	53927289	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agcagggcttccggcatgtgTcccgcagccagtaccaaggc	13	14	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:53927289T>C	uc001cvq.1	+	2	776	c.721T>C	c.(721-723)TCC>CCC	p.S241P		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	241	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCGGCATGTGTCCCGCAGCCA	0.662													0	0	0	0.000602	0	4	73										C	53927289	T	C	53927289	3	2	110	1	0	0	0	0	1	0	0	0	4590	1667	58	5	727	5	DMRTB1	1	53927289	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	7182398	53927289	195323332	17	33529										
LRRC7	57554	broad.mit.edu	37	chr1	70503871	70503871	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaggctgttcccccaggcaaTataccacagcgtcctgaccg	10	15	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:70503871T>C	uc001dep.2	+	19	2280	c.2250T>C	c.(2248-2250)AAT>AAC	p.N750N	LRRC7_uc009wbg.2_Silent_p.N34N|LRRC7_uc001deq.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	750						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCCCAGGCAATATACCACAGC	0.502													0	0	0	0.007835	0	37	189										C	70503871	T	C	70503871	2	2	110	1	0	0	0	0	0	0	0	1	9020	1403	49	5		5	LRRC7	1	70503871	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	16576582	70503871	178746750	18	33530										
GBP5	115362	broad.mit.edu	37	chr1	89730587	89730587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caaggccaggactgcattctCtatgcaaggcagatccccac	9	14	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:89730587C>G	uc001dnc.2	-	8	1468	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	GBP5_uc001dnd.2_Missense_Mutation_p.E311Q|GBP5_uc001dne.1_Missense_Mutation_p.E311Q	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	311						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		ACTGCATTCTCTATGCAAGGC	0.483													0	0	0	0.001855	0	10	78										G	89730587	C	G	89730587	3	3	110	1	0	0	0	0	1	0	0	0	6277	922	32	1	849	1	GBP5	1	89730587	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	19226716	89730587	159520034	19	33531										
EPHX4	253152	broad.mit.edu	37	chr1	92515897	92515897	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atattttacgacaccctgctCagctgttgaaatccagttat	6	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:92515897C>T	uc001don.2	+	5	732	c.628C>T	c.(628-630)CAG>TAG	p.Q210*		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	210						integral to membrane	hydrolase activity			central_nervous_system(1)	1						ACACCCTGCTCAGCTGTTGAA	0.328													0	0	0	0.001168	0	6	104										T	92515897	C	T	92515897	4	4	110	1	0	0	0	0	0	1	0	0	5182	827	29	1	646	1	EPHX4	1	92515897	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2785310	92515897	156734724	20	33532										
MAGI3	260425	broad.mit.edu	37	chr1	114128166	114128166	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agaatggatagctctcttccTgaagaggaagaagatgagga	13	5	1	6			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:114128166T>G	uc001edk.2	+	4	892	c.711T>G	c.(709-711)CCT>CCG	p.P237P	MAGI3_uc001edh.3_Silent_p.P237P|MAGI3_uc001edi.3_Silent_p.P237P|MAGI3_uc010owm.1_Silent_p.P237P	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	237	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTCTCTTCCTGAAGAGGAAG	0.383													0	0	0	0.001368	0	11	57										G	114128166	T	G	114128166	2	3	110	1	0	0	0	0	0	0	0	1	9192	1567	55	5		5	MAGI3	1	114128166	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	21612269	114128166	135122455	21	33533										
TBX15	6913	broad.mit.edu	37	chr1	119427557	119427557	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtaaagtgctttgagaggcgCtcagtttttccgggcttgca	13	8	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:119427557C>T	uc001ehl.1	-	8	1604	c.1289G>A	c.(1288-1290)AGC>AAC	p.S430N	TBX15_uc009whj.1_Missense_Mutation_p.S254N	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	536						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TTGAGAGGCGCTCAGTTTTTC	0.522													0	0	0	0.000602	0	4	43										T	119427557	C	T	119427557	3	4	110	1	0	0	0	0	1	0	0	0	15649	797	28	2	205	2	TBX15	1	119427557	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5299391	119427557	129823064	22	33534										
ANKRD35	148741	broad.mit.edu	37	chr1	145561190	145561190	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggagaaggaggatgaagaccCgtgctcggaggagtggaggt	20	5	0	3	rs80055280	by1000genomes	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:145561190C>T	uc001eob.1	+	10	986	c.878C>T	c.(877-879)CCG>CTG	p.P293L	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.P136L	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	293										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATGAAGACCCGTGCTCGGAG	0.547													0	0	0	0.001984	0	6	49										T	145561190	C	T	145561190	3	4	110	1	0	0	0	0	1	0	0	0	664	652	23	2	916	2	ANKRD35	1	145561190	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	26133633	145561190	103689431	23	33535										
PLEKHO1	51177	broad.mit.edu	37	chr1	150131673	150131673	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagaccccggactcccacctCagacagaccaccccgcacag	7	21	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:150131673C>G	uc001ett.2	+	6	1463	c.1185C>G	c.(1183-1185)CTC>CTG	p.L395L	PLEKHO1_uc001etr.2_Silent_p.L223L|PLEKHO1_uc001ets.2_Silent_p.L212L|PLEKHO1_uc001etu.2_Silent_p.L223L	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	395	Negative regulator of AP-1 activity.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTCCCACCTCAGACAGACCA	0.587													0	0	0	0.008291	0	8	41										G	150131673	C	G	150131673	2	3	110	1	0	0	0	0	0	0	0	1	12084	813	29	1		1	PLEKHO1	1	150131673	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4570483	150131673	99118948	24	33536										
C1orf54	79630	broad.mit.edu	37	chr1	150248191	150248191	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccattgattactccatatttGagtcagaggacaggctggtg	11	8	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:150248191G>C	uc001eud.2	+	3	210	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	C1orf54_uc001euc.2_Missense_Mutation_p.E58Q|C1orf54_uc001eue.2_Missense_Mutation_p.E58Q|C1orf54_uc001euf.2_Missense_Mutation_p.E58Q|C1orf54_uc001eug.2_Missense_Mutation_p.E58Q	NM_024579	NP_078855	Q8WWF1	CA054_HUMAN	hypothetical protein LOC79630 precursor	58						extracellular region					0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCCATATTTGAGTCAGAGGA	0.294													0	0	0	0.008291	0	9	78										C	150248191	G	C	150248191	3	2	110	1	0	0	0	0	1	0	0	0	2046	1291	45	1	182	1	C1orf54	1	150248191	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	116518	150248191	99002430	25	33537										
BNIPL	149428	broad.mit.edu	37	chr1	151015476	151015476	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgggcaccagtgagacagctGaaaggctgggccgaggttgt	17	8	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151015476G>A	uc001ewl.2	+	5	651	c.478G>A	c.(478-480)GAA>AAA	p.E160K	BNIPL_uc009wmi.2_Missense_Mutation_p.E78K|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	160					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAGACAGCTGAAAGGCTGGG	0.517													0	0	0	0.003163	0	14	169										A	151015476	G	A	151015476	3	1	110	1	0	0	0	0	1	0	0	0	1480	1291	45	1	496	1	BNIPL	1	151015476	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	767285	151015476	98235145	26	33538			1	152		3	3	390	G		1.505231e-05
BNIPL	149428	broad.mit.edu	37	chr1	151015532	151015532	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggagaagatggacatcactgGagggtgttccgaatgggacc	16	7	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151015532G>A	uc001ewl.2	+	5	707	c.534G>A	c.(532-534)TGG>TGA	p.W178*	BNIPL_uc009wmi.2_Nonsense_Mutation_p.W96*|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	178					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GACATCACTGGAGGGTGTTCC	0.542													0	0	0	0.006214	0	7	113										A	151015532	G	A	151015532	4	1	110	1	0	0	0	0	0	1	0	0	1480	1183	41	1	552	1	BNIPL	1	151015532	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	56	151015532	98235089	27	33539			1	152		3	3	390	G		1.505231e-05
BNIPL	149428	broad.mit.edu	37	chr1	151015865	151015865	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgcttcctgttatctacccaGaagcagcatccccaactaca	5	15	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151015865G>A	uc001ewl.2	+	6	847	c.674G>A	c.(673-675)AGA>AAA	p.R225K	BNIPL_uc009wmi.2_Missense_Mutation_p.R143K|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	225	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATCTACCCAGAAGCAGCATC	0.463													0	0	0	0.008361	0	25	432										A	151015865	G	A	151015865	3	1	110	1	0	0	0	0	1	0	0	0	1480	942	33	1	696	1	BNIPL	1	151015865	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	333	151015865	98234756	28	33540			1	152		3	3	390	G		1.505231e-05
TMOD4	29765	broad.mit.edu	37	chr1	151147246	151147246	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tacctcaggatccatctcctGtagttcgcagtccagctgct	8	14	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:151147246G>T	uc001exc.3	-	2	296	c.106C>A	c.(106-108)CAG>AAG	p.Q36K	TMOD4_uc001exb.2_5'Flank|TMOD4_uc001exd.2_RNA|TMOD4_uc010pct.1_Missense_Mutation_p.Q36K	NM_013353	NP_037485	Q9NZQ9	TMOD4_HUMAN	tropomodulin 4 (muscle)	36					muscle contraction	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCATCTCCTGTAGTTCGCAG	0.532													1	0	0.00024832	0.009096	0.000257078	4	46										T	151147246	G	T	151147246	3	4	110	1	0	0	0	0	1	0	0	0	16233	1386	48	4	967	4	TMOD4	1	151147246	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	131381	151147246	98103375	29	33541										
FLG	2312	broad.mit.edu	37	chr1	152282137	152282137	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttggtggctctgctgatggGgcccagcctgtccgtgggct	16	12	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:152282137G>T	uc001ezu.1	-	3	5261	c.5225C>A	c.(5224-5226)CCC>CAC	p.P1742H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1742	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTGATGGGGCCCAGCCTG	0.587									Ichthyosis				1	0	6.3237e-29	0.00361	7.04358e-29	50	456										T	152282137	G	T	152282137	3	4	110	1	0	0	0	0	1	0	0	0	5922	1232	43	4	6964	4	FLG	1	152282137	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1134891	152282137	96968484	30	33542										
FLG	2312	broad.mit.edu	37	chr1	152287154	152287154	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagaagaaactcagtgaagtCaattttcttgttgtggtcta	9	6	4	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:152287154C>G	uc001ezu.1	-	3	244	c.208G>C	c.(208-210)GAC>CAC	p.D70H	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	70	EF-hand 2.|Potential.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCAGTGAAGTCAATTTTCTTG	0.408									Ichthyosis				0	0	0	0.001168	0	5	72										G	152287154	C	G	152287154	3	3	110	1	0	0	0	0	1	0	0	0	5922	826	29	1	11981	1	FLG	1	152287154	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5017	152287154	96963467	31	33543										
C1orf189	388701	broad.mit.edu	37	chr1	154173021	154173021	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atacgggtttcttctctggcCcaatgccatttgccacagac	8	13	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154173021C>T	uc001fee.1	-	3	144	c.118G>A	c.(118-120)GGC>AGC	p.G40S		NM_001010979	NP_001010979	Q5VU69	CA189_HUMAN	hypothetical protein LOC388701	40											0	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					CTTCTCTGGCCCAATGCCATT	0.507													0	0	0	0.006122	0	15	401										T	154173021	C	T	154173021	3	4	110	1	0	0	0	0	1	0	0	0	2022	623	22	2	195	2	C1orf189	1	154173021	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1885867	154173021	95077600	32	33544										
UBAP2L	9898	broad.mit.edu	37	chr1	154234112	154234112	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catggtgtgaatgtcagtgtGaatgcatcggccaccccttt	11	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154234112G>A	uc001fep.3	+	24	3008	c.2841G>A	c.(2839-2841)GTG>GTA	p.V947V	UBAP2L_uc009wot.2_Silent_p.V947V|UBAP2L_uc010pek.1_Silent_p.V939V|UBAP2L_uc010pel.1_Silent_p.V957V|UBAP2L_uc010pen.1_Silent_p.V861V|UBAP2L_uc001feq.2_Silent_p.V143V|UBAP2L_uc001fer.2_Silent_p.V143V	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	947					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ATGTCAGTGTGAATGCATCGG	0.512													0	0	0	0.006214	0	8	205										A	154234112	G	A	154234112	2	1	110	1	0	0	0	0	0	0	0	1	16835	1277	45	1		1	UBAP2L	1	154234112	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	61091	154234112	95016509	33	33545										
KCNN3	3782	broad.mit.edu	37	chr1	154698406	154698406	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcttacccgcttggtgagctGagtgtccatcatgaagttat	10	9	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154698406G>A	uc001ffp.2	-	5	2001	c.1687C>T	c.(1687-1689)CAG>TAG	p.Q563*	KCNN3_uc001ffo.2_Nonsense_Mutation_p.Q258*	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	568	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TTGGTGAGCTGAGTGTCCATC	0.522													0	0	0	0.001855	0	10	54										A	154698406	G	A	154698406	4	1	110	1	0	0	0	0	0	1	0	0	8080	1299	45	1	524	1	KCNN3	1	154698406	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	464294	154698406	94552215	34	33546										
ZBTB7B	51043	broad.mit.edu	37	chr1	154987500	154987500	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcgccaacatgccagctgtgCtccaggctgcccgcctgctg	12	17	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:154987500C>T	uc001fgk.3	+	3	522	c.364C>T	c.(364-366)CTC>TTC	p.L122F	ZBTB7B_uc009wpa.2_Missense_Mutation_p.L122F|ZBTB7B_uc001fgj.3_Missense_Mutation_p.L156F|ZBTB7B_uc010peq.1_Missense_Mutation_p.L156F|ZBTB7B_uc001fgl.3_Missense_Mutation_p.L122F	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	122					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCAGCTGTGCTCCAGGCTGC	0.607													0	0	0	0.006214	0	6	67										T	154987500	C	T	154987500	3	4	110	1	0	0	0	0	1	0	0	0	17551	797	28	2	366	2	ZBTB7B	1	154987500	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	289094	154987500	94263121	35	33547										
NTRK1	4914	broad.mit.edu	37	chr1	156845889	156845889	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caggtgttcaccacatcaagCgccgggacatcgtgctcaag	11	13	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:156845889C>T	uc001fqh.1	+	13	1575	c.1519C>T	c.(1519-1521)CGC>TGC	p.R507C	NTRK1_uc001fqf.1_Missense_Mutation_p.R471C|NTRK1_uc009wsi.1_Missense_Mutation_p.R206C|NTRK1_uc001fqi.1_Missense_Mutation_p.R501C|NTRK1_uc009wsk.1_Missense_Mutation_p.R504C	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	507	Cytoplasmic (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	CCACATCAAGCGCCGGGACAT	0.602			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			0	0	0	0.006122	0	14	187										T	156845889	C	T	156845889	3	4	110	1	0	0	0	0	1	0	0	0	10706	768	27	2	1699	2	NTRK1	1	156845889	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1858389	156845889	92404732	36	33548										
KIRREL	55243	broad.mit.edu	37	chr1	158063421	158063421	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcccgtcccaggtcgcaaaGacgtgaccctgaggaagctg	12	14	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:158063421G>C	uc001frn.3	+	13	1992	c.1588G>C	c.(1588-1590)GAC>CAC	p.D530H	KIRREL_uc010pib.1_Missense_Mutation_p.D430H|KIRREL_uc009wsq.2_Missense_Mutation_p.D366H|KIRREL_uc001fro.3_Missense_Mutation_p.D344H|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	530	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					AGGTCGCAAAGACGTGACCCT	0.607													0	0	0	0.009096	0	3	45										C	158063421	G	C	158063421	3	2	110	1	0	0	0	0	1	0	0	0	8324	942	33	1	1638	1	KIRREL	1	158063421	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1217532	158063421	91187200	37	33549										
CD1E	913	broad.mit.edu	37	chr1	158325252	158325252	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaacatctgtaaagtgctcaAtcgctacctagatattaagg	8	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:158325252A>G	uc001fse.2	+	3	757	c.518A>G	c.(517-519)AAT>AGT	p.N173S	CD1E_uc010pid.1_Missense_Mutation_p.N171S|CD1E_uc010pie.1_Missense_Mutation_p.N74S|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.N173S|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.N173S|CD1E_uc001fry.2_Missense_Mutation_p.N173S|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.N173S|CD1E_uc009wsv.2_Missense_Mutation_p.N74S|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	173					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					AAAGTGCTCAATCGCTACCTA	0.498													0	0	0	0.001168	0	5	72										G	158325252	A	G	158325252	3	3	110	1	0	0	0	0	1	0	0	0	2978	101	4	5	528	5	CD1E	1	158325252	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	261831	158325252	90925369	38	33550										
OR6K3	391114	broad.mit.edu	37	chr1	158687408	158687408	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggttgggcccacagaaaggCagtgtggaaatcatcacaat	12	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:158687408C>A	uc010pip.1	-	1	546	c.546G>T	c.(544-546)CTG>CTT	p.L182L		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CACAGAAAGGCAGTGTGGAAA	0.512													1	0	0.00198382	0.001984	0.0020327	7	114										A	158687408	C	A	158687408	2	1	110	1	0	0	0	0	0	0	0	1	11203	697	25	4		4	OR6K3	1	158687408	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	362156	158687408	90563213	39	33551										
BLZF1	8548	broad.mit.edu	37	chr1	169351299	169351299	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gttcatgtgtgttctatgcaGattattggaggagctcttag	12	5	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:169351299G>A	uc001gfx.1	+	6	1235	c.798_splice	c.e6-1	p.K266_splice	BLZF1_uc001gfy.2_Splice_Site_p.K266_splice|BLZF1_uc009wvp.1_Intron	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1						cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					GTTCTATGCAGATTATTGGAG	0.358													0	0	0	0.010504	0	19	242										A	169351299	G	A	169351299	5	1	110	1	0	0	0	0	0	0	1	0	1453	956	33	1	815	1	BLZF1	1	169351299	Splice_Site	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	10663891	169351299	79899322	40	33552										
RASAL2	9462	broad.mit.edu	37	chr1	178423706	178423706	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tctcaaacaccccaggctttGatggttacattgatctgggc	9	11	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:178423706G>C	uc001glr.2	+	10	1815	c.1690G>C	c.(1690-1692)GAT>CAT	p.D564H	RASAL2_uc001glq.2_Missense_Mutation_p.D712H|RASAL2_uc009wxc.2_Missense_Mutation_p.D78H	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	564					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						CCCAGGCTTTGATGGTTACAT	0.423													0	0	0	0.00308	0	8	89										C	178423706	G	C	178423706	3	2	110	1	0	0	0	0	1	0	0	0	13064	1290	45	1	2197	1	RASAL2	1	178423706	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9072407	178423706	70826915	41	33553										
HMCN1	83872	broad.mit.edu	37	chr1	186094827	186094827	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtagctgatggaatccccacAccagcaattaactggaaaaa	8	10	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:186094827A>G	uc001grq.1	+	82	12820	c.12591A>G	c.(12589-12591)ACA>ACG	p.T4197T	HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4197	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAATCCCCACACCAGCAATTA	0.403													0	0	0	0.000978	0	7	100										G	186094827	A	G	186094827	2	3	110	1	0	0	0	0	0	0	0	1	7220	146	6	5		5	HMCN1	1	186094827	Silent	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	7671121	186094827	63155794	42	33554										
CRB1	23418	broad.mit.edu	37	chr1	197390669	197390669	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atggagagtggcatttcgtgGaggtaatatttgcagaggct	15	4	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:197390669G>A	uc001gtz.2	+	6	1846	c.1711G>A	c.(1711-1713)GAG>AAG	p.E571K	CRB1_uc010poz.1_Missense_Mutation_p.E502K|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.E459K|CRB1_uc010ppb.1_Missense_Mutation_p.E571K|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Missense_Mutation_p.E52K|CRB1_uc001gub.1_Missense_Mutation_p.E220K	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	571	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						GCATTTCGTGGAGGTAATATT	0.448													0	0	0	0.00308	0	6	159										A	197390669	G	A	197390669	3	1	110	1	0	0	0	0	1	0	0	0	3848	1175	41	1	1733	1	CRB1	1	197390669	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	11295842	197390669	51859952	43	33555										
DENND1B	163486	broad.mit.edu	37	chr1	197641247	197641247	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttactttcaatgtctgtcagTacaaaggtaaagtgctgtcc	8	8	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:197641247T>G	uc001guf.3	-	5	554	c.216A>C	c.(214-216)GTA>GTC	p.V72V	DENND1B_uc010ppe.1_Silent_p.V72V|DENND1B_uc010ppf.1_RNA|DENND1B_uc001gue.3_Silent_p.V62V	NM_144977	NP_659414	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 2	72	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						TGTCTGTCAGTACAAAGGTAA	0.358													0	0	0	0.000978	0	9	43										G	197641247	T	G	197641247	2	3	110	1	0	0	0	0	0	0	0	1	4427	1625	57	5		5	DENND1B	1	197641247	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	250578	197641247	51609374	44	33556										
CACNA1S	779	broad.mit.edu	37	chr1	201061110	201061110	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgccacccactaggcaccccCgacaccagccggaggggtct	11	18	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:201061110C>T	uc001gvv.2	-	4	758	c.531G>A	c.(529-531)TCG>TCA	p.S177S		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	177	Helical; Name=S4 of repeat I; (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TAGGCACCCCCGACACCAGCC	0.612													0	0	0	0.00308	0	8	39										T	201061110	C	T	201061110	2	4	110	1	0	0	0	0	0	0	0	1	2547	639	23	2		2	CACNA1S	1	201061110	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3419863	201061110	48189511	45	33557										
ELF3	1999	broad.mit.edu	37	chr1	201980309	201980309	+	Frame_Shift_Del	DEL	C	C	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aacatttttagcaactacttCagtgcgatgtacagctcgga							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:201980309delC	uc001gxg.3	+	1	3237	c.45delC	c.(43-45)TTCfs	p.F15fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.F15fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.F15fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	15					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GCAACTACTTCAGTGCGATGT	0.577																		54	249	---	---								-	201980309	C	-	201980309	7	5	110	1	0	1	0	1	0	0	0	0	5055	825	29	0	47	0	ELF3	1	201980309	Frame_Shift_Del	DEL	C	TCGA-GD-A3OP-01A-21D-A21Z-08	919199	201980309	47270312	46	33558										
USH2A	7399	broad.mit.edu	37	chr1	215901707	215901707	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacaaataaaacagactcctCttcaatgccagcagggcgtc	8	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:215901707C>T	uc001hku.1	-	61	12118	c.11731G>A	c.(11731-11733)GAG>AAG	p.E3911K		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3911	Fibronectin type-III 24.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGACTCCTCTTCAATGCCA	0.448										HNSCC(13;0.011)			0	0	0	0.009096	0	4	47										T	215901707	C	T	215901707	3	4	110	1	0	0	0	0	1	0	0	0	17033	922	32	1	3925	1	USH2A	1	215901707	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	13921398	215901707	33348914	47	33559										
BPNT1	10380	broad.mit.edu	37	chr1	220240712	220240712	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcataagcaattccaataaGaactgttacattgtcaagaa	5	7	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:220240712G>C	uc001hma.2	-	6	578	c.406C>G	c.(406-408)CTT>GTT	p.L136V	BPNT1_uc010pug.1_Missense_Mutation_p.L81V|BPNT1_uc010puh.1_Missense_Mutation_p.L100V|BPNT1_uc001hmb.3_Missense_Mutation_p.L136V	NM_006085	NP_006076	O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	136					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0558)		ATTCCAATAAGAACTGTTACA	0.308													0	0	0	0.001168	0	6	92										C	220240712	G	C	220240712	3	2	110	1	0	0	0	0	1	0	0	0	1494	942	33	1	536	1	BPNT1	1	220240712	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4339005	220240712	29009909	48	33560										
CAPN2	824	broad.mit.edu	37	chr1	223959545	223959545	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgtcaactccaccaagtcatCgttgctcggtttgcagatga	9	11	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:223959545C>T	uc001hob.3	+	19	2162	c.1938C>T	c.(1936-1938)ATC>ATT	p.I646I	CAPN2_uc010puy.1_Silent_p.I568I|CAPN2_uc001hoc.2_Silent_p.I227I	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	646	Domain IV.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		ACCAAGTCATCGTTGCTCGGT	0.428													0	0	0	0.00499	0	16	221										T	223959545	C	T	223959545	2	4	110	1	0	0	0	0	0	0	0	1	2627	874	31	1		1	CAPN2	1	223959545	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3718833	223959545	25291076	49	33561										
TMEM63A	9725	broad.mit.edu	37	chr1	226034879	226034879	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggagacagtgctgtcctctcCgaggccaagccgttcagaat	12	12	2	2	rs138912199		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:226034879C>T	uc001hpm.1	-	24	2536	c.2286G>A	c.(2284-2286)TCG>TCA	p.S762S		NM_014698	NP_055513	O94886	TM63A_HUMAN	transmembrane protein 63A	762						integral to membrane|lysosomal membrane	nucleotide binding			ovary(1)|breast(1)	2	Breast(184;0.197)					CTGTCCTCTCCGAGGCCAAGC	0.597													0	0	0	0.004007	0	12	198										T	226034879	C	T	226034879	2	4	110	1	0	0	0	0	0	0	0	1	16187	639	23	2		2	TMEM63A	1	226034879	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2075334	226034879	23215742	50	33562										
PARP1	142	broad.mit.edu	37	chr1	226564877	226564877	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaatttttggagtgccaagCgttcccggttttttcttcat	9	8	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:226564877C>T	uc001hqd.3	-	13	2044	c.1873G>A	c.(1873-1875)GCT>ACT	p.A625T		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	625					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GAGTGCCAAGCGTTCCCGGTT	0.458								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.00361	0	84	241										T	226564877	C	T	226564877	3	4	110	1	0	0	0	0	1	0	0	0	11454	768	27	2	1215	2	PARP1	1	226564877	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	529998	226564877	22685744	51	33563										
CDC42BPA	8476	broad.mit.edu	37	chr1	227261689	227261689	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgacatatccagtttcgcaaAacgacgcattttccagggca	8	11	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:227261689A>G	uc001hqr.2	-	19	3554	c.2611T>C	c.(2611-2613)TTT>CTT	p.F871L	CDC42BPA_uc001hqq.2_Missense_Mutation_p.F135L|CDC42BPA_uc001hqs.2_Missense_Mutation_p.F790L|CDC42BPA_uc009xes.2_Missense_Mutation_p.F871L|CDC42BPA_uc010pvs.1_Missense_Mutation_p.F871L|CDC42BPA_uc001hqp.2_Missense_Mutation_p.F27L|CDC42BPA_uc001hqu.1_Missense_Mutation_p.F27L	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	871					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				AGTTTCGCAAAACGACGCATT	0.378													0	0	0	0.00245	0	10	221										G	227261689	A	G	227261689	3	3	110	1	0	0	0	0	1	0	0	0	3072	14	1	5	2620	5	CDC42BPA	1	227261689	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	696812	227261689	21988932	52	33564										
NID1	4811	broad.mit.edu	37	chr1	236180524	236180524	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gttcctgggtgattattgcaGattgtgtggctcccacacac	11	10	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:236180524G>A	uc001hxo.2	-	10	2280	c.2178C>T	c.(2176-2178)ATC>ATT	p.I726I	NID1_uc009xgd.2_Intron	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	726	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GATTATTGCAGATTGTGTGGC	0.438													0	0	0	0.000978	0	9	208										A	236180524	G	A	236180524	2	1	110	1	0	0	0	0	0	0	0	1	10414	932	33	1		1	NID1	1	236180524	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	8918835	236180524	13070097	53	33565										
ZP4	57829	broad.mit.edu	37	chr1	238049174	238049174	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctacttactgagtagctgcaGctgacatggagcctgcagag	12	10	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:238049174G>A	uc001hym.2	-	7	852	c.852C>T	c.(850-852)AGC>AGT	p.S284S	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	284	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AGTAGCTGCAGCTGACATGGA	0.478													0	0	0	0.000602	0	5	68										A	238049174	G	A	238049174	2	1	110	1	0	0	0	0	0	0	0	1	18215	962	34	2		2	ZP4	1	238049174	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1868650	238049174	11201447	54	33566										
FMN2	56776	broad.mit.edu	37	chr1	240370862	240370862	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccctccccctcctcttcccgGagcgggcatacctcctccgc	7	23	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:240370862G>A	uc010pyd.1	+	5	2975	c.2750G>A	c.(2749-2751)GGA>GAA	p.G917E	FMN2_uc010pye.1_Missense_Mutation_p.G921E	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	917	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTCTTCCCGGAGCGGGCATA	0.657													0	0	0	0.008871	0	14	291										A	240370862	G	A	240370862	3	1	110	1	0	0	0	0	1	0	0	0	5950	1174	41	1	2768	1	FMN2	1	240370862	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2321688	240370862	8879759	55	33567										
OR13G1	441933	broad.mit.edu	37	chr1	247836307	247836307	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcaggctttttggtgaggcCcagaataatgaactcagtta	10	7	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:247836307C>A	uc001idi.1	-	1	37	c.37G>T	c.(37-39)GGC>TGC	p.G13C		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTGGTGAGGCCCAGAATAATG	0.413													1	0	1.01871e-10	0.008871	1.11723e-10	14	78										A	247836307	C	A	247836307	3	1	110	1	0	0	0	0	1	0	0	0	10942	623	22	4	890	4	OR13G1	1	247836307	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	7465445	247836307	1414314	56	33568										
OR6F1	343169	broad.mit.edu	37	chr1	247875997	247875997	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gagagagagctgaagagtttGagaaccaggaaagcccagta	14	6	0	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:247875997G>C	uc001idj.1	-	1	61	c.61C>G	c.(61-63)CAA>GAA	p.Q21E		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAAGAGTTTGAGAACCAGGA	0.473													0	0	0	0.008871	0	16	207										C	247875997	G	C	247875997	3	2	110	1	0	0	0	0	1	0	0	0	11201	1299	45	1	869	1	OR6F1	1	247875997	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	39690	247875997	1374624	57	33569										
OR2T33	391195	broad.mit.edu	37	chr1	248436919	248436919	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaaccagcatcatgtccatGagggaaagttggctcaggag	13	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:248436919G>A	uc010pzi.1	-	1	198	c.198C>T	c.(196-198)CTC>CTT	p.L66L		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATGTCCATGAGGGAAAGTT	0.547													0	0	0	0.000978	0	10	198										A	248436919	G	A	248436919	2	1	110	1	0	0	0	0	0	0	0	1	11024	1277	45	1		1	OR2T33	1	248436919	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	560922	248436919	813702	58	33570										
OR2G6	391211	broad.mit.edu	37	chr1	248685808	248685808	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtcaccccacttttaaacccCattatctacactctgagaaa	3	14	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr1:248685808C>T	uc001ien.1	+	1	861	c.861C>T	c.(859-861)CCC>CCT	p.P287P		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTTAAACCCCATTATCTACA	0.448													0	0	0	0.004007	0	15	45										T	248685808	C	T	248685808	2	4	110	1	0	0	0	0	0	0	0	1	11000	581	21	2		2	OR2G6	1	248685808	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	248889	248685808	564813	59	33571										
UBXN2A	165324	broad.mit.edu	37	chr2	24194153	24194153	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttatcttgtttagggtttgtGaaacaggatctgataatcaa	9	4	3	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:24194153G>A	uc010exy.2	+	4	517	c.49G>A	c.(49-51)GAA>AAA	p.E17K	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.E17K|UBXN2A_uc010ykj.1_Missense_Mutation_p.E17K	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	17											0						TAGGGTTTGTGAAACAGGATC	0.308													0	0	0	0.004482	0	7	100										A	24194153	G	A	24194153	3	1	110	1	0	0	0	0	1	0	0	0	16911	1291	45	1	55	1	UBXN2A	2	24194153	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		24194153	219005220	60	33572										
MAPRE3	22924	broad.mit.edu	37	chr2	27248831	27248831	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttcgtgacatcgagctcatCtgccaggagcatgaaagtga	11	10	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27248831C>G	uc002rhw.2	+	6	861	c.708C>G	c.(706-708)ATC>ATG	p.I236M	MAPRE3_uc002rhx.2_Missense_Mutation_p.I221M	NM_012326	NP_036458	Q9UPY8	MARE3_HUMAN	microtubule-associated protein, RP/EB family,	236	APC-binding.|EB1 C-terminal.|DCTN1-binding.				cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGAGCTCATCTGCCAGGAGC	0.537													0	0	0	0.003163	0	12	90										G	27248831	C	G	27248831	3	3	110	1	0	0	0	0	1	0	0	0	9296	903	32	1	726	1	MAPRE3	2	27248831	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3054678	27248831	215950542	61	33573										
C2orf16	84226	broad.mit.edu	37	chr2	27805353	27805353	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcgggaccacacataaaaatCccaaagcagggcaagtgtgg	11	10	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27805353C>T	uc002rkz.3	+	1	5965	c.5914C>T	c.(5914-5916)CCC>TCC	p.P1972S	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1972										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACATAAAAATCCCAAAGCAGG	0.507													0	0	0	0.003954	0	19	188										T	27805353	C	T	27805353	3	4	110	1	0	0	0	0	1	0	0	0	2157	855	30	1	5916	1	C2orf16	2	27805353	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	556522	27805353	215394020	62	33574										
CCDC121	79635	broad.mit.edu	37	chr2	27850025	27850025	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctttgagtagccgttagtttCtgggcttgctcaattagctg	11	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27850025C>G	uc002rle.2	-	2	823	c.642G>C	c.(640-642)CAG>CAC	p.Q214H	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Missense_Mutation_p.Q378H|CCDC121_uc002rld.2_Missense_Mutation_p.Q376H|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	214	Potential.										0	Acute lymphoblastic leukemia(172;0.155)					CCGTTAGTTTCTGGGCTTGCT	0.478													0	0	0	0.004482	0	9	38										G	27850025	C	G	27850025	3	3	110	1	0	0	0	0	1	0	0	0	2757	912	32	1	198	1	CCDC121	2	27850025	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	44672	27850025	215349348	63	33575										
SLC4A1AP	22950	broad.mit.edu	37	chr2	27900720	27900720	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacctgagaacttttgaactGaggaaagaacaacagagact	9	8	0	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:27900720G>A	uc002rlk.3	+	8	1974	c.1692G>A	c.(1690-1692)CTG>CTA	p.L564L		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	564						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					CTTTTGAACTGAGGAAAGAAC	0.358													0	0	0	0.000978	0	10	68										A	27900720	G	A	27900720	2	1	110	1	0	0	0	0	0	0	0	1	14653	1277	45	1		1	SLC4A1AP	2	27900720	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	50695	27900720	215298653	64	33576										
NLRC4	58484	broad.mit.edu	37	chr2	32475775	32475775	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagtggtccaggctccgaatGaagtcacttgcagccacacc	10	14	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32475775G>C	uc002roi.2	-	4	1404	c.1158C>G	c.(1156-1158)TTC>TTG	p.F386L	NLRC4_uc002roj.1_Missense_Mutation_p.F386L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	386	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GGCTCCGAATGAAGTCACTTG	0.468													0	0	0	0.008291	0	9	56										C	32475775	G	C	32475775	3	2	110	1	0	0	0	0	1	0	0	0	10469	1281	45	1	1940	1	NLRC4	2	32475775	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4575055	32475775	210723598	65	33577										
BIRC6	57448	broad.mit.edu	37	chr2	32668572	32668572	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttttcagtaatggcaaatgtGacccatgtcaaccagcattt	7	9	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32668572G>T	uc010ezu.2	+	20	4386	c.4252G>T	c.(4252-4254)GAC>TAC	p.D1418Y		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1418					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGGCAAATGTGACCCATGTCA	0.333													1	0	0.004672	0.004672	0.00477731	3	19										T	32668572	G	T	32668572	3	4	110	1	0	0	0	0	1	0	0	0	1438	1290	45	3	4330	3	BIRC6	2	32668572	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	192797	32668572	210530801	66	33578										
BIRC6	57448	broad.mit.edu	37	chr2	32670646	32670646	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaagatgaagatctggctgGatgcagtacagcttgtgcat	13	6	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32670646G>A	uc010ezu.2	+	21	4528	c.4394G>A	c.(4393-4395)GGA>GAA	p.G1465E		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1465					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GATCTGGCTGGATGCAGTACA	0.378													0	0	0	0.00499	0	13	39										A	32670646	G	A	32670646	3	1	110	1	0	0	0	0	1	0	0	0	1438	1174	41	1	4476	1	BIRC6	2	32670646	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2074	32670646	210528727	67	33579										
BIRC6	57448	broad.mit.edu	37	chr2	32673888	32673888	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gattatatagctcaccatttGatccagtcctctttgatttg	6	9	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:32673888G>A	uc010ezu.2	+	22	4644	c.4510G>A	c.(4510-4512)GAT>AAT	p.D1504N		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1504					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCACCATTTGATCCAGTCCT	0.313													0	0	0	0.006122	0	14	54										A	32673888	G	A	32673888	3	1	110	1	0	0	0	0	1	0	0	0	1438	1290	45	1	4596	1	BIRC6	2	32673888	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3242	32673888	210525485	68	33580										
ATL2	64225	broad.mit.edu	37	chr2	38570616	38570616	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acatggtttcttcataacctCatcagaatttactaggtcat	5	9	5	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:38570616C>G	uc002rqq.2	-	2	187	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	ATL2_uc010ynm.1_Missense_Mutation_p.E35Q|ATL2_uc010ynn.1_Missense_Mutation_p.E35Q|ATL2_uc010yno.1_Intron|ATL2_uc002rqs.2_Missense_Mutation_p.E53Q|ATL2_uc002rqr.2_Intron	NM_001135673	NP_001129145	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2 isoform 2	53	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3						TTCATAACCTCATCAGAATTT	0.338													0	0	0	0.006214	0	7	65										G	38570616	C	G	38570616	3	3	110	1	0	0	0	0	1	0	0	0	1107	835	29	1	1754	1	ATL2	2	38570616	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5896728	38570616	204628757	69	33581										
NRXN1	9378	broad.mit.edu	37	chr2	50850623	50850623	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gccgatttcccagtgtgaagCatcagtccattcctctgaag	9	12	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:50850623C>T	uc010fbq.2	-	6	2539	c.1062G>A	c.(1060-1062)ATG>ATA	p.M354I	NRXN1_uc002rxb.3_Missense_Mutation_p.M1I|NRXN1_uc002rxe.3_Missense_Mutation_p.M321I|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAGTGTGAAGCATCAGTCCAT	0.433													0	0	0	0.00632	0	22	181										T	50850623	C	T	50850623	3	4	110	1	0	0	0	0	1	0	0	0	10665	710	25	2	3916	2	NRXN1	2	50850623	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	12280007	50850623	192348750	70	33582										
GPR75	10936	broad.mit.edu	37	chr2	54081274	54081274	+	Missense_Mutation	SNP	T	T	C													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agaaggtgaagtcgaccacaTagagagacaaaatggctttc							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:54081274T>C	uc002rxo.3	-	2	891	c.620A>G	c.(619-621)TAT>TGT	p.Y207C	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	207	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTCGACCACATAGAGAGACAA	0.507													0	0	0	0.00308	0	7	117										C	54081274	T	C	54081274	3	2	110	1	0	0	0	0	1	0	0	0	6708	1406	49	5	1006	5	GPR75	2	54081274	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	3230651	54081274	189118099	71	33583	170	2								
GPR75	10936	broad.mit.edu	37	chr2	54081280	54081280	+	Missense_Mutation	SNP	G	G	C													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgaagtcgaccacatagagaGacaaaatggctttccctttt							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:54081280G>C	uc002rxo.3	-	2	885	c.614C>G	c.(613-615)TCT>TGT	p.S205C	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	205	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CACATAGAGAGACAAAATGGC	0.493													0	0	0	0.004482	0	8	114										C	54081280	G	C	54081280	3	2	110	1	0	0	0	0	1	0	0	0	6708	942	33	1	1012	1	GPR75	2	54081280	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6	54081280	189118093	72	33584	170	2								
SERTAD2	9792	broad.mit.edu	37	chr2	64863402	64863402	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gagtttctgggtgccagcctCgctggaggtccctttcacac	12	13	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:64863402C>T	uc002sde.1	-	2	901	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_014755	NP_055570	Q14140	SRTD2_HUMAN	SERTA domain containing 2	202					negative regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleus					0						GTGCCAGCCTCGCTGGAGGTC	0.567													0	0	0	0.005443	0	24	77										T	64863402	C	T	64863402	3	4	110	1	0	0	0	0	1	0	0	0	14121	893	31	1	344	1	SERTAD2	2	64863402	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	10782122	64863402	178335971	73	33585										
C2orf68	388969	broad.mit.edu	37	chr2	85836116	85836116	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcctcctggatacgcaacttGagggcttctcgcatgggtgg	13	11	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:85836116G>C	uc002sqc.2	-	4	525	c.453C>G	c.(451-453)CTC>CTG	p.L151L	USP39_uc002sqb.2_Intron	NM_001013649	NP_001013671	Q2NKX9	CB068_HUMAN	hypothetical protein LOC388969	151										central_nervous_system(1)	1						TACGCAACTTGAGGGCTTCTC	0.552													0	0	0	0.006214	0	7	115										C	85836116	G	C	85836116	2	2	110	1	0	0	0	0	0	0	0	1	2187	1277	45	1		1	C2orf68	2	85836116	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	20972714	85836116	157363257	74	33586										
TEKT4	150483	broad.mit.edu	37	chr2	95537570	95537570	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acccaggcgctggcgcagcgCacgcagcaagactccacgcg	13	17	0	1	rs66467545		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:95537570C>T	uc002stw.1	+	1	339	c.246C>T	c.(244-246)CGC>CGT	p.R82R	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	82					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						TGGCGCAGCGCACGCAGCAAG	0.692													0	0	0	0.001984	0	4	24										T	95537570	C	T	95537570	2	4	110	1	0	0	0	0	0	0	0	1	15752	697	25	2		2	TEKT4	2	95537570	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	9701454	95537570	147661803	75	33587										
C2orf55	343990	broad.mit.edu	37	chr2	99413948	99413948	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtgacggtgatccagggtggCgcaggctgcccatcagctcc	15	13	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:99413948C>T	uc002szf.1	-	8	2763	c.2469G>A	c.(2467-2469)GCG>GCA	p.A823A		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	823	Pro-rich.										0						TCCAGGGTGGCGCAGGCTGCC	0.587													0	0	0	0.004007	0	12	101										T	99413948	C	T	99413948	2	4	110	1	0	0	0	0	0	0	0	1	2176	755	27	2		2	C2orf55	2	99413948	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3876378	99413948	143785425	76	33588										
NEB	4703	broad.mit.edu	37	chr2	152553184	152553184	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttggaattgacttgggcttgTagcagaacaggagagtctgt	14	5	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:152553184T>C	uc010fnx.2	-	17	1727	c.1536A>G	c.(1534-1536)CTA>CTG	p.L512L	NEB_uc010fny.1_Silent_p.L66L	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	512	Nebulin 12.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTGGGCTTGTAGCAGAACAG	0.403													0	0	0	0.001168	0	5	59										C	152553184	T	C	152553184	2	2	110	1	0	0	0	0	0	0	0	1	10302	1625	57	5		5	NEB	2	152553184	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	53139236	152553184	90646189	77	33589										
TTN	7273	broad.mit.edu	37	chr2	179482573	179482573	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccaactccaattcgattttgGgctctcactcggaaactgta	7	12	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179482573G>A	uc010zfg.1	-	202	40025	c.39801C>T	c.(39799-39801)GCC>GCT	p.A13267A	TTN_uc010zfh.1_Silent_p.A6962A|TTN_uc010zfi.1_Silent_p.A6895A|TTN_uc010zfj.1_Silent_p.A6770A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14194							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCGATTTTGGGCTCTCACTC	0.463													0	0	0	0.004482	0	9	96										A	179482573	G	A	179482573	2	1	110	1	0	0	0	0	0	0	0	1	16732	1219	43	2		2	TTN	2	179482573	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	26929389	179482573	63716800	78	33590										
TTN	7273	broad.mit.edu	37	chr2	179497319	179497319	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catgtattttgcttcatcttCaaaagcagctgacttgatca	6	9	4	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179497319C>G	uc010zfg.1	-	184	35934	c.35710G>C	c.(35710-35712)GAA>CAA	p.E11904Q	TTN_uc010zfh.1_Missense_Mutation_p.E5599Q|TTN_uc010zfi.1_Missense_Mutation_p.E5532Q|TTN_uc010zfj.1_Missense_Mutation_p.E5407Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12831							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCATCTTCAAAAGCAGCT	0.388													0	0	0	0.001855	0	14	113										G	179497319	C	G	179497319	3	3	110	1	0	0	0	0	1	0	0	0	16732	835	29	1	64791	1	TTN	2	179497319	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	14746	179497319	63702054	79	33591										
TTN	7273	broad.mit.edu	37	chr2	179575936	179575936	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgtttgtacatttgggctgtCtttcaatggcttgccgtctt	10	8	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179575936C>G	uc010zfg.1	-	94	24519	c.24295G>C	c.(24295-24297)GAC>CAC	p.D8099H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D4760H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9026							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGGCTGTCTTTCAATGGC	0.423													0	0	0	0.00333	0	17	227										G	179575936	C	G	179575936	3	3	110	1	0	0	0	0	1	0	0	0	16732	913	32	1	76566	1	TTN	2	179575936	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	78617	179575936	63623437	80	33592										
TTN	7273	broad.mit.edu	37	chr2	179577067	179577067	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgagtatttgtgctgaacaGgaatcttttccagaggcatt	10	6	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179577067G>T	uc010zfg.1	-	92	24074	c.23850C>A	c.(23848-23850)TCC>TCA	p.S7950S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S4611S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8877							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGCTGAACAGGAATCTTTTC	0.388													1	0	4.47668e-21	0.003954	4.9752e-21	20	243										T	179577067	G	T	179577067	2	4	110	1	0	0	0	0	0	0	0	1	16732	987	35	4		4	TTN	2	179577067	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1131	179577067	63622306	81	33593										
CCDC141	285025	broad.mit.edu	37	chr2	179720159	179720159	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgtcaaagtcatccacatgtTtttgcaaatccttcatgact	5	10	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:179720159T>A	uc002unf.1	-	9	1307	c.1250A>T	c.(1249-1251)AAA>ATA	p.K417I		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	417							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			ATCCACATGTTTTTGCAAATC	0.343													0	0	0	0.000602	0	4	73										A	179720159	T	A	179720159	3	1	110	1	0	0	0	0	1	0	0	0	2775	1841	64	5	1397	5	CCDC141	2	179720159	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	143092	179720159	63479214	82	33594										
NEUROD1	4760	broad.mit.edu	37	chr2	182543034	182543034	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gattgagttgcaggcagcccGcaaccaggttggtggtgggt	17	8	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:182543034G>A	uc002uof.2	-	2	790	c.554C>T	c.(553-555)GCG>GTG	p.A185V	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	185				A -> G (in Ref. 2; BAA11558 and 5; BAA87605).	amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CAGGCAGCCCGCAACCAGGTT	0.612													0	0	0	0.001168	0	6	59										A	182543034	G	A	182543034	3	1	110	1	0	0	0	0	1	0	0	0	10348	1087	38	2	520	2	NEUROD1	2	182543034	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2822875	182543034	60656339	83	33595										
NUP35	129401	broad.mit.edu	37	chr2	183993048	183993048	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gatgctgggttcacccacatCtccaaagccaggagttaatg	10	11	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:183993048C>T	uc002upf.2	+	2	177	c.74C>T	c.(73-75)TCT>TTT	p.S25F	NUP35_uc010zfs.1_Missense_Mutation_p.S7F|NUP35_uc010zft.1_5'UTR|NUP35_uc002upg.2_RNA	NM_138285	NP_612142	Q8NFH5	NUP53_HUMAN	nucleoporin 35kDa	25					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	intermediate filament cytoskeleton|nuclear membrane|nuclear pore|plasma membrane					0						TCACCCACATCTCCAAAGCCA	0.418													0	0	0	0.000602	0	5	55										T	183993048	C	T	183993048	3	4	110	1	0	0	0	0	1	0	0	0	10763	913	32	1	80	1	NUP35	2	183993048	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1450014	183993048	59206325	84	33596										
WDR75	84128	broad.mit.edu	37	chr2	190333285	190333285	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctttgctgttggaatctgctGagctgtgcatgtaagatatt	11	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:190333285G>A	uc002uql.1	+	15	1773	c.1713G>A	c.(1711-1713)CTG>CTA	p.L571L	WDR75_uc002uqm.1_Silent_p.L507L|WDR75_uc002uqn.1_Silent_p.L349L|WDR75_uc002uqo.1_Silent_p.L349L	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	571	WD 9.					nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			GGAATCTGCTGAGCTGTGCAT	0.388													0	0	0	0.008291	0	8	130										A	190333285	G	A	190333285	2	1	110	1	0	0	0	0	0	0	0	1	17322	1277	45	1		1	WDR75	2	190333285	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6340237	190333285	52866088	85	33597										
FAM126B	285172	broad.mit.edu	37	chr2	201853102	201853102	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctggccttcttgtgtagaatCaggagcatcaaatggtaatg	11	7	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:201853102C>T	uc002uws.3	-	11	1062	c.874G>A	c.(874-876)GAT>AAT	p.D292N	FAM126B_uc002uwu.2_Missense_Mutation_p.D210N|FAM126B_uc002uwv.2_Missense_Mutation_p.D292N	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	292						intracellular				ovary(1)	1						TGTGTAGAATCAGGAGCATCA	0.378													0	0	0	0.000978	0	9	89										T	201853102	C	T	201853102	3	4	110	1	0	0	0	0	1	0	0	0	5430	826	29	1	726	1	FAM126B	2	201853102	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	11519817	201853102	41346271	86	33598										
MAP2	4133	broad.mit.edu	37	chr2	210560669	210560669	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagacacccttcagataactGacctgggtgtctcaggtgcc	10	13	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:210560669G>A	uc002vde.1	+	7	4023	c.3775G>A	c.(3775-3777)GAC>AAC	p.D1259N	MAP2_uc002vdc.1_Missense_Mutation_p.D1259N|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D1255N	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1259					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TCAGATAACTGACCTGGGTGT	0.483													0	0	0	0.003163	0	14	84										A	210560669	G	A	210560669	3	1	110	1	0	0	0	0	1	0	0	0	9235	1290	45	1	3789	1	MAP2	2	210560669	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	8707567	210560669	32638704	87	33599										
TMEM169	92691	broad.mit.edu	37	chr2	216965210	216965210	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcttgaatccgacaatatctCaagcactctctccaacaagg	6	13	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:216965210C>G	uc010zjr.1	+	4	1165	c.839C>G	c.(838-840)TCA>TGA	p.S280*	TMEM169_uc010zjs.1_Nonsense_Mutation_p.S280*|TMEM169_uc002vfw.2_Nonsense_Mutation_p.S280*|TMEM169_uc002vfv.3_Nonsense_Mutation_p.S280*	NM_001142310	NP_001135782	Q96HH4	TM169_HUMAN	transmembrane protein 169	280	Extracellular (Potential).					integral to membrane				ovary(1)	1		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACAATATCTCAAGCACTCTC	0.512													0	0	0	0.00308	0	7	84										G	216965210	C	G	216965210	4	3	110	1	0	0	0	0	0	1	0	0	16081	838	29	1	845	1	TMEM169	2	216965210	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6404541	216965210	26234163	88	33600										
IHH	3549	broad.mit.edu	37	chr2	219925066	219925066	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggcgagcggcacgagtttgcGtggcggtcgccggcggctgc	20	12	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:219925066G>A	uc002vjo.1	-	1	124	c.124C>T	c.(124-126)CGC>TGC	p.R42C	hsa-mir-3131|MI0014151_5'Flank	NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	42					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACGAGTTTGCGTGGCGGTCGC	0.692													0	0	0	0.004672	0	3	47										A	219925066	G	A	219925066	3	1	110	1	0	0	0	0	1	0	0	0	7607	1145	40	2	1123	2	IHH	2	219925066	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2959856	219925066	23274307	89	33601										
ABCB6	10058	broad.mit.edu	37	chr2	220077977	220077977	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctcacccatcggcatagctGaagtgcacgttctcaaactc	7	15	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr2:220077977G>A	uc002vkc.1	-	12	2068	c.1791C>T	c.(1789-1791)TTC>TTT	p.F597F	ABCB6_uc010fwe.1_Silent_p.F551F	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	597	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGGCATAGCTGAAGTGCACGT	0.537													0	0	0	0.001984	0	6	45										A	220077977	G	A	220077977	2	1	110	1	0	0	0	0	0	0	0	1	45	1281	45	1		1	ABCB6	2	220077977	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	152911	220077977	23121396	90	33602										
HRH1	3269	broad.mit.edu	37	chr3	11301168	11301168	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cccgagcctcggccaccattCtgggggcctggtttctctct	11	16	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:11301168C>T	uc010hdr.2	+	2	787	c.445C>T	c.(445-447)CTG>TTG	p.L149L	HRH1_uc010hds.2_Silent_p.L149L|HRH1_uc010hdt.2_Silent_p.L149L|HRH1_uc003bwb.3_Silent_p.L149L	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	149	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GGCCACCATTCTGGGGGCCTG	0.542													0	0	0	0.001168	0	6	97										T	11301168	C	T	11301168	2	4	110	1	0	0	0	0	0	0	0	1	7355	912	32	1		1	HRH1	3	11301168	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		11301168	186721262	91	33603										
NUP210	23225	broad.mit.edu	37	chr3	13401814	13401814	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacaaggatccagtgttgctGataattccgggaggaatggg	14	7	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:13401814G>T	uc003bxv.1	-	15	2193	c.2110C>A	c.(2110-2112)CAG>AAG	p.Q704K	NUP210_uc003bxx.2_Missense_Mutation_p.Q376K	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	704	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CAGTGTTGCTGATAATTCCGG	0.567													1	0	1.96292e-10	0.010504	2.14802e-10	18	79										T	13401814	G	T	13401814	3	4	110	1	0	0	0	0	1	0	0	0	10760	1299	45	3	3657	3	NUP210	3	13401814	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2100646	13401814	184620616	92	33604										
ARPP21	10777	broad.mit.edu	37	chr3	35729240	35729240	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttccccaacaggaatcaattCatttacagctttccagtttt	4	11	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:35729240C>A	uc003cgb.2	+	6	535	c.271C>A	c.(271-273)CAT>AAT	p.H91N	ARPP21_uc003cga.2_Missense_Mutation_p.H91N|ARPP21_uc011axy.1_Missense_Mutation_p.H91N|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	91						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GGAATCAATTCATTTACAGCT	0.338													1	0	1.15088e-07	0.004007	1.23503e-07	11	92										A	35729240	C	A	35729240	3	1	110	1	0	0	0	0	1	0	0	0	978	826	29	3	298	3	ARPP21	3	35729240	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	22327426	35729240	162293190	93	33605										
TRANK1	9881	broad.mit.edu	37	chr3	36896768	36896768	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggcataatggaacagagagCgcagatcgctgaagcggaag	15	7	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:36896768C>A	uc003cgj.2	-	3	2965	c.2663G>T	c.(2662-2664)CGC>CTC	p.R888L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1438					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GAACAGAGAGCGCAGATCGCT	0.542													1	0	9.95505e-16	0.002299	1.1039e-15	21	133										A	36896768	C	A	36896768	3	1	110	1	0	0	0	0	1	0	0	0	16451	768	27	4	4512	4	TRANK1	3	36896768	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1167528	36896768	161125662	94	33606										
VILL	50853	broad.mit.edu	37	chr3	38048129	38048129	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcaacgggggcctgcgccggGaacaactgatgcaccaggct	14	13	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:38048129G>A	uc003chj.2	+	19	2681	c.2395G>A	c.(2395-2397)GAA>AAA	p.E799K	VILL_uc003chl.2_Missense_Mutation_p.E799K	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	799	HP.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CCTGCGCCGGGAACAACTGAT	0.657													0	0	0	0.00278	0	21	74										A	38048129	G	A	38048129	3	1	110	1	0	0	0	0	1	0	0	0	17162	1175	41	1	2465	1	VILL	3	38048129	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1151361	38048129	159974301	95	33607										
DLEC1	9940	broad.mit.edu	37	chr3	38163892	38163892	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgagagatacatgttgcctCaccagccctgaggctccgcc	10	14	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:38163892C>G	uc003cho.1	+	37	5278	c.5257C>G	c.(5257-5259)CAC>GAC	p.H1753D	DLEC1_uc003chp.1_Silent_p.L1711L|DLEC1_uc010hgv.1_Missense_Mutation_p.H1756D|DLEC1_uc003chr.1_Missense_Mutation_p.H824D|DLEC1_uc003chs.1_Silent_p.L268L	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1753					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CATGTTGCCTCACCAGCCCTG	0.602													0	0	0	0.006214	0	7	121										G	38163892	C	G	38163892	3	3	110	1	0	0	0	0	1	0	0	0	4552	826	29	1	5403	1	DLEC1	3	38163892	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	115763	38163892	159858538	96	33608										
TRAK1	22906	broad.mit.edu	37	chr3	42226217	42226217	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggccgctcgcatcggccagtCgttgttgaagaagaacaaga	13	10	0	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:42226217C>A	uc003cky.2	+	4	620	c.404C>A	c.(403-405)TCG>TAG	p.S135*	TRAK1_uc011azh.1_Nonsense_Mutation_p.S135*|TRAK1_uc011azi.1_Nonsense_Mutation_p.S135*|TRAK1_uc003ckz.3_Nonsense_Mutation_p.S61*|TRAK1_uc011azj.1_Nonsense_Mutation_p.S61*|TRAK1_uc003cla.2_Nonsense_Mutation_p.S77*	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	135	Potential.|HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						ATCGGCCAGTCGTTGTTGAAG	0.507													1	0	1.36491e-13	0.001855	1.50684e-13	12	180										A	42226217	C	A	42226217	4	1	110	1	0	0	0	0	0	1	0	0	16446	893	31	3	534	3	TRAK1	3	42226217	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4062325	42226217	155796213	97	33609										
TRAK1	22906	broad.mit.edu	37	chr3	42226284	42226284	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaggagcaggtggaacacatCagggaggaggtaagacattg	17	5	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:42226284C>T	uc003cky.2	+	4	687	c.471C>T	c.(469-471)ATC>ATT	p.I157I	TRAK1_uc011azh.1_Silent_p.I157I|TRAK1_uc011azi.1_Silent_p.I157I|TRAK1_uc003ckz.3_Silent_p.I83I|TRAK1_uc011azj.1_Silent_p.I83I|TRAK1_uc003cla.2_Silent_p.I99I	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	157	Potential.|HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TGGAACACATCAGGGAGGAGG	0.582													0	0	0	0.000978	0	10	165										T	42226284	C	T	42226284	2	4	110	1	0	0	0	0	0	0	0	1	16446	816	29	1		1	TRAK1	3	42226284	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	67	42226284	155796146	98	33610										
PTH1R	5745	broad.mit.edu	37	chr3	46942574	46942574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gagctaccctggccaacaccGggtaggtccaggtggagaag	15	11	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:46942574G>A	uc003cqm.2	+	11	1251	c.1048G>A	c.(1048-1050)GGG>AGG	p.G350R	PTH1R_uc003cqn.2_Missense_Mutation_p.G350R	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	350	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GGCCAACACCGGGTAGGTCCA	0.627									Ollier_disease_/_Maffuci_syndrome				0	0	0	0.004672	0	3	15										A	46942574	G	A	46942574	3	1	110	1	0	0	0	0	1	0	0	0	12758	1130	39	2	1082	2	PTH1R	3	46942574	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4716290	46942574	151079856	99	33611										
QARS	5859	broad.mit.edu	37	chr3	49137079	49137079	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagccagaagtaggaagagcGtctggggtgggagagtaggg	20	4	1	3	rs141072684		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:49137079G>A	uc003cvx.2	-	16	1395	c.1390C>T	c.(1390-1392)CGC>TGC	p.R464C	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.R319C|QARS_uc003cvy.2_Missense_Mutation_p.R319C|QARS_uc011bce.1_Missense_Mutation_p.R453C	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	464					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	TAGGAAGAGCGTCTGGGGTGG	0.572													0	0	0	0.00499	0	16	44										A	49137079	G	A	49137079	3	1	110	1	0	0	0	0	1	0	0	0	12871	1159	40	2	973	2	QARS	3	49137079	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2194505	49137079	148885351	100	33612										
ALAS1	211	broad.mit.edu	37	chr3	52237973	52237978	+	In_Frame_Del	DEL	GCAAAA	GCAAAA	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagaacttccaggacatcatGcaaaagcaaagaccagaaag							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:52237973_52237978delGCAAAA	uc003dcy.1	+	5	859_864	c.522_527delGCAAAA	c.(520-528)ATGCAAAAG>ATG	p.QK175del	ALAS1_uc003dcz.1_In_Frame_Del_p.QK175del|ALAS1_uc011bec.1_In_Frame_Del_p.QK192del	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	175_176					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AGGACATCATGCAAAAGCAAAGACCA	0.422																		15	133	---	---								-	52237978	GCAAAA	-	52237973	7	5	110	1	0	1	0	1	0	0	0	0	484	1319	46	0	532	0	ALAS1	3	52237973	In_Frame_Del	DEL	GCAAAA	TCGA-GD-A3OP-01A-21D-A21Z-08	3100894	52237973	145784457	101	33613										
ITIH3	3699	broad.mit.edu	37	chr3	52836749	52836749	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggagaaggccctgcaggagCgggactacatcttcgggaat	15	9	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:52836749C>T	uc003dfv.2	+	13	1672	c.1636C>T	c.(1636-1638)CGG>TGG	p.R546W	ITIH3_uc011bek.1_Intron	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	546					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CCTGCAGGAGCGGGACTACAT	0.602													0	0	0	0.006214	0	8	97										T	52836749	C	T	52836749	3	4	110	1	0	0	0	0	1	0	0	0	7905	759	27	2	1686	2	ITIH3	3	52836749	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	598776	52836749	145185681	102	33614										
SLMAP	7871	broad.mit.edu	37	chr3	57908654	57908654	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtactctcagaactgaagttGaagtttgaaatgactgagca	10	6	1	6			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:57908654G>A	uc003dje.1	+	21	2503	c.2298G>A	c.(2296-2298)TTG>TTA	p.L766L	SLMAP_uc003djd.1_Silent_p.L749L|SLMAP_uc003djf.1_Silent_p.L728L|SLMAP_uc003djg.1_Silent_p.L360L|SLMAP_uc011bez.1_Silent_p.L234L|SLMAP_uc011bfa.1_Silent_p.L300L|SLMAP_uc003dji.1_Silent_p.L300L|SLMAP_uc011bfb.1_Silent_p.L300L|SLMAP_uc011bfc.1_Silent_p.L259L	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	766	Cytoplasmic (Potential).|Potential.				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		AACTGAAGTTGAAGTTTGAAA	0.368													0	0	0	0.009096	0	4	77										A	57908654	G	A	57908654	2	1	110	1	0	0	0	0	0	0	0	1	14749	1281	45	1		1	SLMAP	3	57908654	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5071905	57908654	140113776	103	33615										
CNTN3	5067	broad.mit.edu	37	chr3	74535680	74535680	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcaaaacattggtaagttccTgtatcccaatttctgttggg	9	8	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:74535680T>C	uc003dpm.1	-	3	365	c.285A>G	c.(283-285)ACA>ACG	p.T95T		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	95	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GGTAAGTTCCTGTATCCCAAT	0.373													0	0	0	0.001984	0	5	88										C	74535680	T	C	74535680	2	2	110	1	0	0	0	0	0	0	0	1	3642	1567	55	5		5	CNTN3	3	74535680	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	16627026	74535680	123486750	104	33616										
GBE1	2632	broad.mit.edu	37	chr3	81586104	81586104	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tatctttcttccaatctattCatatccctgtcaaaattatt	1	10	5	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:81586104C>T	uc003dqg.2	-	14	2044	c.1761G>A	c.(1759-1761)ATG>ATA	p.M587I	GBE1_uc011bgm.1_Missense_Mutation_p.M546I	NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	587					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CCAATCTATTCATATCCCTGT	0.413									Glycogen_Storage_Disease_type_IV				0	0	0	0.001168	0	5	88										T	81586104	C	T	81586104	3	4	110	1	0	0	0	0	1	0	0	0	6270	826	29	1	363	1	GBE1	3	81586104	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	7050424	81586104	116436326	105	33617										
OR5H2	79310	broad.mit.edu	37	chr3	98002337	98002337	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacccttctattaattttctAatggtttttattttgtctgg	6	6	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:98002337A>G	uc003dsj.1	+	1	606	c.606A>G	c.(604-606)CTA>CTG	p.L202L		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						TTAATTTTCTAATGGTTTTTA	0.308													0	0	0	0.003163	0	13	42										G	98002337	A	G	98002337	2	3	110	1	0	0	0	0	0	0	0	1	11162	349	13	5		5	OR5H2	3	98002337	Silent	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	16416233	98002337	100020093	106	33618										
OR5K2	402135	broad.mit.edu	37	chr3	98217064	98217064	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atcaaccacttttactgtgaTactcttcccttgtatagact	4	11	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:98217064T>C	uc011bgx.1	+	1	540	c.540T>C	c.(538-540)GAT>GAC	p.D180D		NM_001004737	NP_001004737	Q8NHB8	OR5K2_HUMAN	olfactory receptor, family 5, subfamily K,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TTTACTGTGATACTCTTCCCT	0.403													0	0	0	0.004007	0	13	272										C	98217064	T	C	98217064	2	2	110	1	0	0	0	0	0	0	0	1	11167	1403	49	5		5	OR5K2	3	98217064	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	214727	98217064	99805366	107	33619										
CLDND1	56650	broad.mit.edu	37	chr3	98235645	98235645	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atccaaattcaccggatacaTtgtcagggagctctagtttc	8	10	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:98235645T>C	uc003dsp.2	-	5	1500	c.620A>G	c.(619-621)AAT>AGT	p.N207S	CLDND1_uc003dso.2_Intron|CLDND1_uc003dsq.2_Missense_Mutation_p.N207S|CLDND1_uc003dss.2_Missense_Mutation_p.N207S|CLDND1_uc003dsr.2_Missense_Mutation_p.N112S|CLDND1_uc003dst.2_Missense_Mutation_p.N230S|CLDND1_uc003dsu.2_Missense_Mutation_p.N207S|CLDND1_uc003dsv.2_Missense_Mutation_p.N207S	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	207						integral to membrane				ovary(1)	1						ACCGGATACATTGTCAGGGAG	0.478													0	0	0	0.00499	0	14	69										C	98235645	T	C	98235645	3	2	110	1	0	0	0	0	1	0	0	0	3493	1493	52	5	145	5	CLDND1	3	98235645	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	18581	98235645	99786785	108	33620										
RG9MTD1	54931	broad.mit.edu	37	chr3	101283942	101283942	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gatgtggagattgcttggcaGagaagtaccagaacacatca	12	7	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:101283942G>C	uc003duz.2	+	2	465	c.317G>C	c.(316-318)AGA>ACA	p.R106T		NM_017819	NP_060289	Q7L0Y3	MRRP1_HUMAN	RNA (guanine-9-) methyltransferase domain	106					tRNA processing	mitochondrion	methyltransferase activity|protein binding			ovary(1)	1						TTGCTTGGCAGAGAAGTACCA	0.373													0	0	0	0.001368	0	9	116										C	101283942	G	C	101283942	3	2	110	1	0	0	0	0	1	0	0	0	13271	942	33	1	319	1	RG9MTD1	3	101283942	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3048297	101283942	96738488	109	33621										
KIAA1524	57650	broad.mit.edu	37	chr3	108273331	108273331	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tattcttcttttcagtacttTcatttctgaaaagacaagaa	4	7	5	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:108273331T>C	uc003dxb.3	-	18	2485	c.2216A>G	c.(2215-2217)GAA>GGA	p.E739G		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	739	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTCAGTACTTTCATTTCTGAA	0.323													0	0	0	0.004672	0	2	8										C	108273331	T	C	108273331	3	2	110	1	0	0	0	0	1	0	0	0	8239	1783	62	5	517	5	KIAA1524	3	108273331	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	6989389	108273331	89749099	110	33622										
SLC35A5	55032	broad.mit.edu	37	chr3	112299549	112299549	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tccaattcctgccttcttttCagaagtgagtgtcccagaaa	7	11	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:112299549C>T	uc003dze.2	+	6	830	c.585C>T	c.(583-585)TTC>TTT	p.F195F		NM_017945	NP_060415	Q9BS91	S35A5_HUMAN	solute carrier family 35, member A5	195						Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1						GCCTTCTTTTCAGAAGTGAGT	0.463													0	0	0	0.000978	0	10	70										T	112299549	C	T	112299549	2	4	110	1	0	0	0	0	0	0	0	1	14574	825	29	1		1	SLC35A5	3	112299549	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4026218	112299549	85722881	111	33623										
ZXDC	79364	broad.mit.edu	37	chr3	126157291	126157291	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtccagcagggcctccagatGaggggagcacctcctgcaaa	13	13	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:126157291G>A	uc003eiv.2	-	10	2558	c.2504C>T	c.(2503-2505)TCA>TTA	p.S835L	ZXDC_uc010hsh.2_RNA	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	835	Interaction with CIITA.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		GCCTCCAGATGAGGGGAGCAC	0.627													0	0	0	0.000602	0	4	33										A	126157291	G	A	126157291	3	1	110	1	0	0	0	0	1	0	0	0	18249	1294	45	1	76	1	ZXDC	3	126157291	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	13857742	126157291	71865139	112	33624										
NPHP3	27031	broad.mit.edu	37	chr3	132418250	132418250	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaacaattactcttacattCactggcagtggatctatcag	7	9	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:132418250C>T	uc003epe.1	-	13	2009	c.1932G>A	c.(1930-1932)GTG>GTA	p.V644V	NPHP3_uc003epd.1_5'UTR	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	644					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						CTCTTACATTCACTGGCAGTG	0.323													0	0	0	0.00308	0	6	58										T	132418250	C	T	132418250	2	4	110	1	0	0	0	0	0	0	0	1	10580	813	29	1		1	NPHP3	3	132418250	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6260959	132418250	65604180	113	33625										
SLCO2A1	6578	broad.mit.edu	37	chr3	133661560	133661560	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacaggggacagggcacgatCctgtctttgctgaagcggat	14	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:133661560C>T	uc003eqa.3	-	11	1788	c.1514G>A	c.(1513-1515)GGA>GAA	p.G505E	SLCO2A1_uc003eqb.3_Missense_Mutation_p.G429E|SLCO2A1_uc011blv.1_Missense_Mutation_p.G324E	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	505	Extracellular (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						AGGGCACGATCCTGTCTTTGC	0.532													0	0	0	0.008361	0	22	122										T	133661560	C	T	133661560	3	4	110	1	0	0	0	0	1	0	0	0	14726	855	30	1	433	1	SLCO2A1	3	133661560	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1243310	133661560	64360870	114	33626										
TIPARP	25976	broad.mit.edu	37	chr3	156395594	156395594	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tctgagaagatcactccattGaagacttgttttaagaaaaa	7	6	2	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:156395594G>A	uc003fav.2	+	2	356	c.108G>A	c.(106-108)TTG>TTA	p.L36L	LOC100287227_uc011boq.1_5'Flank|TIPARP_uc003faw.2_Silent_p.L36L	NM_015508	NP_056323	Q7Z3E1	PARPT_HUMAN	TCDD-inducible poly(ADP-ribose) polymerase	36							NAD+ ADP-ribosyltransferase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|breast(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TCACTCCATTGAAGACTTGTT	0.448													0	0	0	0.006214	0	8	76										A	156395594	G	A	156395594	2	1	110	1	0	0	0	0	0	0	0	1	15921	1281	45	1		1	TIPARP	3	156395594	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	22734034	156395594	41626836	115	33627										
PIK3CA	5290	broad.mit.edu	37	chr3	178927486	178927486	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaggccgaaagggtgctaaaGaggtaaagtatttcagaagg	14	4	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:178927486G>A	uc003fjk.2	+	7	1406	c.1249G>A	c.(1249-1251)GAG>AAG	p.E417K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	417	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GGGTGCTAAAGAGGTAAAGTA	0.343		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.003163	0	14	91										A	178927486	G	A	178927486	3	1	110	1	0	0	0	0	1	0	0	0	11913	943	33	1	1271	1	PIK3CA	3	178927486	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	22531892	178927486	19094944	116	33628										
MFN1	55669	broad.mit.edu	37	chr3	179080190	179080190	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttcacatggacaaagatttGaaagctggctgtcttgtacg	10	8	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:179080190G>A	uc003fjs.2	+	5	582	c.456G>A	c.(454-456)TTG>TTA	p.L152L	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Silent_p.L180L|MFN1_uc010hxc.2_Silent_p.L5L	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	152	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			ACAAAGATTTGAAAGCTGGCT	0.383													0	0	0	0.006214	0	7	94										A	179080190	G	A	179080190	2	1	110	1	0	0	0	0	0	0	0	1	9523	1281	45	1		1	MFN1	3	179080190	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	152704	179080190	18942240	117	33629										
MCCC1	56922	broad.mit.edu	37	chr3	182769981	182769981	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttacagctttagcagctctGactgcagcttctcccagctt	7	13	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:182769981G>A	uc003fle.2	-	9	1058	c.921C>T	c.(919-921)GTC>GTT	p.V307V	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.V190V|MCCC1_uc003flg.2_Silent_p.V198V|MCCC1_uc011bqp.1_Silent_p.V260V|MCCC1_uc011bqq.1_Silent_p.V198V	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	307	Biotin carboxylation.|ATP-grasp.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	TAGCAGCTCTGACTGCAGCTT	0.348													0	0	0	0.008291	0	7	81										A	182769981	G	A	182769981	2	1	110	1	0	0	0	0	0	0	0	1	9374	1277	45	1		1	MCCC1	3	182769981	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3689791	182769981	15252449	118	33630										
TNK2	10188	broad.mit.edu	37	chr3	195608974	195608974	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacgtaatggtcgtcattctGaggtagtgctcgcatcagcc	12	10	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr3:195608974G>A	uc003fvu.1	-	6	1378	c.835C>T	c.(835-837)CAG>TAG	p.Q279*	TNK2_uc003fvs.1_Nonsense_Mutation_p.Q311*|TNK2_uc003fvt.1_Nonsense_Mutation_p.Q342*|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Nonsense_Mutation_p.Q109*|TNK2_uc010hzx.1_Intron	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	279	Protein kinase.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TCGTCATTCTGAGGTAGTGCT	0.602													0	0	0	0.00308	0	6	77										A	195608974	G	A	195608974	4	1	110	1	0	0	0	0	0	1	0	0	16315	1299	45	1	2370	1	TNK2	3	195608974	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	12838993	195608974	2413456	119	33631										
GAK	2580	broad.mit.edu	37	chr4	844870	844870	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcagagacttttggcttttGagctagaaaagaacagaaac	9	7	1	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:844870G>A	uc003gbm.3	-	26	3710	c.3511C>T	c.(3511-3513)CAA>TAA	p.Q1171*	GAK_uc003gbn.3_Nonsense_Mutation_p.Q1092*|GAK_uc003gbk.3_Intron|GAK_uc010ibi.2_Nonsense_Mutation_p.Q396*|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Nonsense_Mutation_p.Q1024*	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1171					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		TTTGGCTTTTGAGCTAGAAAA	0.264													0	0	0	0.000602	0	5	64										A	844870	G	A	844870	4	1	110	1	0	0	0	0	0	1	0	0	6195	1299	45	1	436	1	GAK	4	844870	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		844870	190309406	120	33632										
HTT	3064	broad.mit.edu	37	chr4	3214330	3214330	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtccctgcccactctggcccGggccctggcacagtacctgg	12	18	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:3214330G>A	uc011bvq.1	+	50	6819	c.6674G>A	c.(6673-6675)CGG>CAG	p.R2225Q		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2223					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		ACTCTGGCCCGGGCCCTGGCA	0.552													0	0	0	0.008871	0	17	235										A	3214330	G	A	3214330	3	1	110	1	0	0	0	0	1	0	0	0	7457	1116	39	2	6862	2	HTT	4	3214330	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2369460	3214330	187939946	121	33633										
C4orf50	389197	broad.mit.edu	37	chr4	5961300	5961300	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gggagacctggttccacagtGaccgctgccaggcacgttcc	13	14	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:5961300G>A	uc003git.1	-	7	723	c.633C>T	c.(631-633)GTC>GTT	p.V211V		NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197	211										pancreas(2)|breast(1)	3						GTTCCACAGTGACCGCTGCCA	0.577													0	0	0	0.001984	0	5	44										A	5961300	G	A	5961300	2	1	110	1	0	0	0	0	0	0	0	1	2276	1277	45	1		1	C4orf50	4	5961300	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2746970	5961300	185192976	122	33634										
KIAA0232	9778	broad.mit.edu	37	chr4	6843853	6843853	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagaaatggggaaagagtaaGaaaaaatgttcagatctaac	10	3	2	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:6843853G>A	uc003gjr.3	+	4	754	c.291G>A	c.(289-291)AAG>AAA	p.K97K	KIAA0232_uc003gjq.3_Silent_p.K97K	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	97							ATP binding			ovary(2)	2						GAAAGAGTAAGAAAAAATGTT	0.388													0	0	0	0.000978	0	10	104										A	6843853	G	A	6843853	2	1	110	1	0	0	0	0	0	0	0	1	8163	933	33	1		1	KIAA0232	4	6843853	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	882553	6843853	184310423	123	33635										
BOD1L	259282	broad.mit.edu	37	chr4	13605601	13605601	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgctgaagaagaagcagtctCtaatacaggttcaacaccag	9	9	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:13605601C>G	uc003gmz.1	-	10	3040	c.2923G>C	c.(2923-2925)GAG>CAG	p.E975Q	BOD1L_uc010idr.1_Missense_Mutation_p.E312Q	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	975	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GAAGCAGTCTCTAATACAGGT	0.378													0	0	0	0.00499	0	12	177										G	13605601	C	G	13605601	3	3	110	1	0	0	0	0	1	0	0	0	1483	922	32	1	6300	1	BOD1L	4	13605601	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6761748	13605601	177548675	124	33636										
BOD1L	259282	broad.mit.edu	37	chr4	13605643	13605643	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcttcaaaaggtttgtcttCaactttagacttacgctgtt	6	8	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:13605643C>T	uc003gmz.1	-	10	2998	c.2881G>A	c.(2881-2883)GAA>AAA	p.E961K	BOD1L_uc010idr.1_Missense_Mutation_p.E298K	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	961	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						GGTTTGTCTTCAACTTTAGAC	0.398													0	0	0	0.006214	0	9	143										T	13605643	C	T	13605643	3	4	110	1	0	0	0	0	1	0	0	0	1483	835	29	1	6342	1	BOD1L	4	13605643	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	42	13605643	177548633	125	33637										
UGDH	7358	broad.mit.edu	37	chr4	39512009	39512009	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaagaccaagtattagtggtGaggatcttttctctgggaac	12	6	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:39512009G>C	uc003guk.1	-	5	943	c.627C>G	c.(625-627)CTC>CTG	p.L209L	UGDH_uc011byp.1_Silent_p.L112L|UGDH_uc003gul.1_Silent_p.L142L	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	209					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	TATTAGTGGTGAGGATCTTTT	0.423													0	0	0	0.008291	0	7	119										C	39512009	G	C	39512009	2	2	110	1	0	0	0	0	0	0	0	1	16937	1277	45	1		1	UGDH	4	39512009	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	25906366	39512009	151642267	126	33638										
DCAF4L1	285429	broad.mit.edu	37	chr4	41984112	41984112	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaggctccaagtacggcatCatcagcctgcgaactctgaa	10	12	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:41984112C>G	uc003gwk.2	+	1	400	c.303C>G	c.(301-303)ATC>ATG	p.I101M		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	101										skin(1)	1						AGTACGGCATCATCAGCCTGC	0.557													0	0	0	0.001984	0	6	62										G	41984112	C	G	41984112	3	3	110	1	0	0	0	0	1	0	0	0	4271	816	29	1	305	1	DCAF4L1	4	41984112	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2472103	41984112	149170164	127	33639										
GABRA2	2555	broad.mit.edu	37	chr4	46334652	46334652	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catatctgtatctgagacagGgccaaaactggtcacgtaga	10	9	3	2	rs76519302		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:46334652G>T	uc003gxc.3	-	3	908	c.235C>A	c.(235-237)CCT>ACT	p.P79T	GABRA2_uc010igc.2_Missense_Mutation_p.P79T|GABRA2_uc011bzc.1_Intron|GABRA2_uc003gxe.2_Missense_Mutation_p.P79T	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	79	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTGAGACAGGGCCAAAACTG	0.328													1	0	1.33987e-11	0.008291	1.47268e-11	7	123										T	46334652	G	T	46334652	3	4	110	1	0	0	0	0	1	0	0	0	6161	1232	43	4	1148	4	GABRA2	4	46334652	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4350540	46334652	144819624	128	33640										
TEC	7006	broad.mit.edu	37	chr4	48169865	48169865	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gagatactcttggcctctctCtaatctgagatcatgtcctt	7	11	5	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:48169865C>T	uc003gxz.2	-	7	692	c.601G>A	c.(601-603)GAG>AAG	p.E201K		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	201	SH3.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						TGGCCTCTCTCTAATCTGAGA	0.403													0	0	0	0.008291	0	10	141										T	48169865	C	T	48169865	3	4	110	1	0	0	0	0	1	0	0	0	15739	922	32	1	1342	1	TEC	4	48169865	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1835213	48169865	142984411	129	33641										
KDR	3791	broad.mit.edu	37	chr4	55958791	55958791	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caacctttcttacctttcgcGatgccaagaactccatgccc	5	16	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:55958791G>A	uc003has.2	-	22	3364	c.3062C>T	c.(3061-3063)TCG>TTG	p.S1021L	KDR_uc003hat.1_Missense_Mutation_p.S1021L	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1021	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TACCTTTCGCGATGCCAAGAA	0.458			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.00308	0	7	59										A	55958791	G	A	55958791	3	1	110	1	0	0	0	0	1	0	0	0	8139	1059	37	1	1044	1	KDR	4	55958791	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7788926	55958791	135195485	130	33642										
CEP135	9662	broad.mit.edu	37	chr4	56819371	56819371	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaacttgaaaatgcaagattGagtagagaaaataatgaatt	8	2	0	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:56819371G>C	uc003hbi.2	+	3	468	c.234G>C	c.(232-234)TTG>TTC	p.L78F	CEP135_uc003hbh.1_Missense_Mutation_p.L78F|CEP135_uc010igz.1_5'Flank	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	78	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					ATGCAAGATTGAGTAGAGAAA	0.308													0	0	0	0.000602	0	5	67										C	56819371	G	C	56819371	3	2	110	1	0	0	0	0	1	0	0	0	3247	1281	45	1	240	1	CEP135	4	56819371	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	860580	56819371	134334905	131	33643										
AMBN	258	broad.mit.edu	37	chr4	71468378	71468378	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgctgatccacaaggtccatCagtaagtacagatctcaatg	8	10	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:71468378C>T	uc003hfl.2	+	7	644	c.569C>T	c.(568-570)TCA>TTA	p.S190L		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	190	1.				bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			CAAGGTCCATCAGTAAGTACA	0.219													0	0	0	0.004482	0	5	95										T	71468378	C	T	71468378	3	4	110	1	0	0	0	0	1	0	0	0	563	840	29	1	595	1	AMBN	4	71468378	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	14649007	71468378	119685898	132	33644										
GC	2638	broad.mit.edu	37	chr4	72634130	72634130	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acgtgccactgggaaattttCtactgtacaggactagtgac	10	9	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:72634130C>G	uc003hge.2	-	3	302	c.149G>C	c.(148-150)AGA>ACA	p.R50T	GC_uc003hgd.2_5'UTR|GC_uc010iie.2_Missense_Mutation_p.R50T|GC_uc010iif.2_Missense_Mutation_p.R69T	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	50	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GGGAAATTTTCTACTGTACAG	0.388													0	0	0	0.000602	0	4	59										G	72634130	C	G	72634130	3	3	110	1	0	0	0	0	1	0	0	0	6282	913	32	1	1315	1	GC	4	72634130	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1165752	72634130	118520146	133	33645										
MEPE	56955	broad.mit.edu	37	chr4	88766951	88766951	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgagatcccagagagagaaGaaaatggtggaaataccatt	11	5	0	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:88766951G>A	uc003hqy.2	+	4	970	c.931G>A	c.(931-933)GAA>AAA	p.E311K	MEPE_uc010ikn.2_Missense_Mutation_p.E198K	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	311					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AGAGAGAGAAGAAAATGGTGG	0.448													0	0	0	0.004482	0	8	41										A	88766951	G	A	88766951	3	1	110	1	0	0	0	0	1	0	0	0	9478	943	33	1	941	1	MEPE	4	88766951	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	16132821	88766951	102387325	134	33646										
INTS12	57117	broad.mit.edu	37	chr4	106614625	106614625	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctttggaatatcaactccttCagtgatgtctgatttcatct	6	9	5	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:106614625C>T	uc003hxw.2	-	5	586	c.328G>A	c.(328-330)GAA>AAA	p.E110K	INTS12_uc010ilr.2_Missense_Mutation_p.E110K	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	110					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		TCAACTCCTTCAGTGATGTCT	0.378													0	0	0	0.008291	0	9	158										T	106614625	C	T	106614625	3	4	110	1	0	0	0	0	1	0	0	0	7777	835	29	1	1076	1	INTS12	4	106614625	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	17847674	106614625	84539651	135	33647										
HADH	3033	broad.mit.edu	37	chr4	108911132	108911132	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catgcgttccgtgtcctcctCgtccaccgcctcggcctcgg	10	19	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:108911132C>T	uc003hyq.2	+	1	193	c.44C>T	c.(43-45)TCG>TTG	p.S15L	HADH_uc010ilx.2_Missense_Mutation_p.S15L|HADH_uc010ily.2_5'UTR	NM_005327	NP_005318	Q16836	HCDH_HUMAN	L-3-hydroxyacyl-Coenzyme A dehydrogenase	15					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	GTGTCCTCCTCGTCCACCGCC	0.687													0	0	0	0.004672	0	3	37										T	108911132	C	T	108911132	3	4	110	1	0	0	0	0	1	0	0	0	6942	893	31	1	46	1	HADH	4	108911132	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2296507	108911132	82243144	136	33648										
SPATA5	166378	broad.mit.edu	37	chr4	123977578	123977578	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ataaatatgttggtgaatctGaaagagcagttagagaggta	12	2	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:123977578G>C	uc003iez.3	+	12	2189	c.2116G>C	c.(2116-2118)GAA>CAA	p.E706Q		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	706					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						TGGTGAATCTGAAAGAGCAGT	0.378													0	0	0	0.00308	0	5	55										C	123977578	G	C	123977578	3	2	110	1	0	0	0	0	1	0	0	0	15010	1291	45	1	2162	1	SPATA5	4	123977578	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	15066446	123977578	67176698	137	33649										
TRIM2	23321	broad.mit.edu	37	chr4	154237060	154237060	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggggcagctgcagcggcccaCaggagtggctgtacatccca	15	13	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:154237060C>T	uc003ing.2	+	8	1811	c.1610C>T	c.(1609-1611)ACA>ATA	p.T537I	TRIM2_uc003inh.2_Missense_Mutation_p.T564I	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	537	NHL 2.					cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CAGCGGCCCACAGGAGTGGCT	0.448													0	0	0	0.006214	0	7	89										T	154237060	C	T	154237060	3	4	110	1	0	0	0	0	1	0	0	0	16491	478	17	2	1721	2	TRIM2	4	154237060	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	30259482	154237060	36917216	138	33650										
NPY5R	4889	broad.mit.edu	37	chr4	164271709	164271709	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttggttgtgctgttttgctCacctttcacactgacgtctg	9	11	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:164271709C>T	uc003iqn.2	+	4	466	c.284C>T	c.(283-285)TCA>TTA	p.S95L		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	95	Helical; Name=2; (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				CTGTTTTGCTCACCTTTCACA	0.408													0	0	0	0.007413	0	18	286										T	164271709	C	T	164271709	3	4	110	1	0	0	0	0	1	0	0	0	10610	838	29	1	286	1	NPY5R	4	164271709	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	10034649	164271709	26882567	139	33651										
TKTL2	84076	broad.mit.edu	37	chr4	164393349	164393349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggcttcatggagagtaactCcagctccaattactgtgact	9	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:164393349C>T	uc003iqp.3	-	1	1699	c.1538G>A	c.(1537-1539)GGA>GAA	p.G513E		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	513						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GAGAGTAACTCCAGCTCCAAT	0.458													0	0	0	0.006122	0	17	140										T	164393349	C	T	164393349	3	4	110	1	0	0	0	0	1	0	0	0	15933	855	30	1	346	1	TKTL2	4	164393349	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	121640	164393349	26760927	140	33652										
ODZ3	55714	broad.mit.edu	37	chr4	183673159	183673159	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggggatggagggaaggccgTggaagccacactcatgagtc	17	8	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr4:183673159T>C	uc003ivd.1	+	19	3873	c.3836T>C	c.(3835-3837)GTG>GCG	p.V1279A	ODZ3_uc003ive.1_Missense_Mutation_p.V692A	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1279	NHL 2.|Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GGGAAGGCCGTGGAAGCCACA	0.463													0	0	0	0.001168	0	5	23										C	183673159	T	C	183673159	3	2	110	1	0	0	0	0	1	0	0	0	10836	1696	59	5	3910	5	ODZ3	4	183673159	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	19279810	183673159	7481117	141	33653										
TRIO	7204	broad.mit.edu	37	chr5	14399069	14399069	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gggacccaaaaaccttaattCgaaagggtcgagaacggcat	11	9	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:14399069C>T	uc003jff.2	+	30	4510	c.4504C>T	c.(4504-4506)CGA>TGA	p.R1502*	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Nonsense_Mutation_p.R1453*|TRIO_uc003jfh.1_Nonsense_Mutation_p.R1151*	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1502	PH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AACCTTAATTCGAAAGGGTCG	0.398													0	0	0	0.001855	0	11	137										T	14399069	C	T	14399069	4	4	110	1	0	0	0	0	0	1	0	0	16549	876	31	1	4622	1	TRIO	5	14399069	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		14399069	166516191	142	33654										
DAB2	1601	broad.mit.edu	37	chr5	39392476	39392476	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgaattcttaccccagttttCtcatcaattatttttatccc	2	11	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:39392476C>G	uc003jlx.2	-	4	852	c.321G>C	c.(319-321)GAG>GAC	p.E107D	DAB2_uc003jlw.2_Missense_Mutation_p.E107D	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	107	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			CCCCAGTTTTCTCATCAATTA	0.458													0	0	0	0.009096	0	3	48										G	39392476	C	G	39392476	3	3	110	1	0	0	0	0	1	0	0	0	4218	912	32	1	2035	1	DAB2	5	39392476	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	24993407	39392476	141522784	143	33655										
HCN1	348980	broad.mit.edu	37	chr5	45303797	45303797	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaatacatttttttacccaCggctccttctcgtatgatat	5	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:45303797C>T	uc003jok.2	-	6	1547	c.1522G>A	c.(1522-1524)GTG>ATG	p.V508M		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	508	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTTTTACCCACGGCTCCTTCT	0.393													0	0	0	0.004007	0	14	92										T	45303797	C	T	45303797	3	4	110	1	0	0	0	0	1	0	0	0	6996	536	19	2	1162	2	HCN1	5	45303797	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5911321	45303797	135611463	144	33656										
GZMA	3001	broad.mit.edu	37	chr5	54404206	54404206	+	Missense_Mutation	SNP	G	G	A													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgctggaagcctccgaggtgGaagagactcgtgcaatgtaa							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:54404206G>A	uc003jpm.2	+	4	648	c.611G>A	c.(610-612)GGA>GAA	p.G204E		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	204	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CTCCGAGGTGGAAGAGACTCG	0.378													0	0	0	0.006214	0	7	87										A	54404206	G	A	54404206	3	1	110	1	0	0	0	0	1	0	0	0	6915	1174	41	1	625	1	GZMA	5	54404206	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9100409	54404206	126511054	145	33657	171	2								
GZMA	3001	broad.mit.edu	37	chr5	54404209	54404209	+	Missense_Mutation	SNP	G	G	A													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggaagcctccgaggtggaaGagactcgtgcaatgtaagta							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:54404209G>A	uc003jpm.2	+	4	651	c.614G>A	c.(613-615)AGA>AAA	p.R205K		NM_006144	NP_006135	P12544	GRAA_HUMAN	granzyme A precursor	205	Peptidase S1.				cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				CGAGGTGGAAGAGACTCGTGC	0.383													0	0	0	0.008291	0	8	89										A	54404209	G	A	54404209	3	1	110	1	0	0	0	0	1	0	0	0	6915	942	33	1	628	1	GZMA	5	54404209	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3	54404209	126511051	146	33658	171	2								
CD180	4064	broad.mit.edu	37	chr5	66479570	66479570	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtctgaaggtttcctagtttCtccaagcagccaacaccaag	8	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:66479570C>G	uc003juy.2	-	3	1249	c.1101G>C	c.(1099-1101)GAG>GAC	p.E367D		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	367	Extracellular (Potential).				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TTCCTAGTTTCTCCAAGCAGC	0.453													0	0	0	0.004007	0	14	123										G	66479570	C	G	66479570	3	3	110	1	0	0	0	0	1	0	0	0	2972	912	32	1	888	1	CD180	5	66479570	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	12075361	66479570	114435690	147	33659										
ARSB	411	broad.mit.edu	37	chr5	78260315	78260315	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttgaatacatatttttatatCctgttgcaacttcttcgcca	4	9	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:78260315C>T	uc003kfq.2	-	3	1900	c.614G>A	c.(613-615)GGA>GAA	p.G205E	ARSB_uc003kfr.3_Missense_Mutation_p.G205E	NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	205					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		ATTTTTATATCCTGTTGCAAC	0.373													0	0	0	0.004482	0	9	60										T	78260315	C	T	78260315	3	4	110	1	0	0	0	0	1	0	0	0	988	855	30	1	1044	1	ARSB	5	78260315	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	11780745	78260315	102654945	148	33660										
CHD1	1105	broad.mit.edu	37	chr5	98209411	98209411	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atcaactaactcagcatctcGagcaattgcatctaatctgt	5	11	5	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:98209411G>A	uc003knf.2	-	25	3605	c.3457C>T	c.(3457-3459)CGA>TGA	p.R1153*	CHD1_uc010jbn.2_5'UTR	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1153					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TCAGCATCTCGAGCAATTGCA	0.338													0	0	0	0.008291	0	10	90										A	98209411	G	A	98209411	4	1	110	1	0	0	0	0	0	1	0	0	3323	1066	37	1	1719	1	CHD1	5	98209411	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	19949096	98209411	82705849	149	33661										
TNFAIP8	25816	broad.mit.edu	37	chr5	118728967	118728967	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taatgtgtttgatcatttttCagattgtgaatttttggctg	9	3	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:118728967C>T	uc003ksh.2	+	3	1176	c.488C>T	c.(487-489)TCA>TTA	p.S163L	TNFAIP8_uc003ksf.1_3'UTR|TNFAIP8_uc003ksg.2_Missense_Mutation_p.S153L|TNFAIP8_uc011cwf.1_Missense_Mutation_p.S157L|TNFAIP8_uc003ksi.2_Missense_Mutation_p.S163L	NM_014350	NP_055165	O95379	TFIP8_HUMAN	tumor necrosis factor, alpha-induced protein 8	163					anti-apoptosis|apoptosis|negative regulation of anti-apoptosis	cytoplasm	caspase inhibitor activity|protein binding			ovary(1)	1		all_cancers(142;0.0317)|Prostate(80;0.111)|Breast(839;0.231)		Epithelial(69;4.63e-83)|OV - Ovarian serous cystadenocarcinoma(64;1.39e-82)|all cancers(49;4.88e-75)|GBM - Glioblastoma multiforme(465;0.00338)|BRCA - Breast invasive adenocarcinoma(61;0.0148)|COAD - Colon adenocarcinoma(49;0.0829)		GATCATTTTTCAGATTGTGAA	0.388													0	0	0	0.001984	0	7	122										T	118728967	C	T	118728967	3	4	110	1	0	0	0	0	1	0	0	0	16273	838	29	1	499	1	TNFAIP8	5	118728967	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	20519556	118728967	62186293	150	33662										
PCDHB7	56129	broad.mit.edu	37	chr5	140552992	140552992	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggggaggggaatatctatccCgaattggtgctgaatcaagt	14	6	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140552992C>G	uc003lit.2	+	1	750	c.576C>G	c.(574-576)CCC>CCG	p.P192P		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	192	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATATCTATCCCGAATTGGTGC	0.493													0	0	0	0.001984	0	6	84										G	140552992	C	G	140552992	2	3	110	1	0	0	0	0	0	0	0	1	11547	639	23	4		4	PCDHB7	5	140552992	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	21824025	140552992	40362268	151	33663										
PCDHB7	56129	broad.mit.edu	37	chr5	140553379	140553379	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tacacattaactattcaggcCaaagacggcggcgggctttc	10	11	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140553379C>T	uc003lit.2	+	1	1137	c.963C>T	c.(961-963)GCC>GCT	p.A321A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	321	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTATTCAGGCCAAAGACGGCG	0.428													0	0	0	0.00308	0	6	78										T	140553379	C	T	140553379	2	4	110	1	0	0	0	0	0	0	0	1	11547	581	21	2		2	PCDHB7	5	140553379	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	387	140553379	40361881	152	33664										
PCDHB9	56127	broad.mit.edu	37	chr5	140567301	140567301	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cgccagtgtttcggcacaaaGagatggtcttaaaaatatca	9	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140567301G>C	uc003liw.1	+	1	409	c.409G>C	c.(409-411)GAG>CAG	p.E137Q		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	137	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGCACAAAGAGATGGTCTT	0.403													0	0	0	0.001168	0	4	73										C	140567301	G	C	140567301	3	2	110	1	0	0	0	0	1	0	0	0	11549	943	33	1	411	1	PCDHB9	5	140567301	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	13922	140567301	40347959	153	33665										
PCDHGB3	56102	broad.mit.edu	37	chr5	140751513	140751513	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcggggtggtgttcgcgcagCgagccttcgaccacgagcag	17	12	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:140751513C>T	uc003ljw.1	+	1	1552	c.1552C>T	c.(1552-1554)CGA>TGA	p.R518*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Nonsense_Mutation_p.R518*|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	518	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCGCGCAGCGAGCCTTCGA	0.677													0	0	0	0.001168	0	5	73										T	140751513	C	T	140751513	4	4	110	1	0	0	0	0	0	1	0	0	11564	760	27	2	1554	2	PCDHGB3	5	140751513	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	184212	140751513	40163747	154	33666										
HTR4	3360	broad.mit.edu	37	chr5	147928367	147928367	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aatggcaccaaagggcatcaCcagcaccgaaaccagcagat	9	13	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:147928367C>T	uc003lpn.2	-	4	381	c.217G>A	c.(217-219)GTG>ATG	p.V73M	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_Missense_Mutation_p.V73M|HTR4_uc003lpj.1_Missense_Mutation_p.V73M|HTR4_uc003lpk.2_Missense_Mutation_p.V73M|HTR4_uc011dby.1_Missense_Mutation_p.V73M|HTR4_uc003lpl.2_Missense_Mutation_p.V73M|HTR4_uc003lpm.2_Missense_Mutation_p.V73M|HTR4_uc010jgv.2_RNA|HTR4_uc003lpo.1_Missense_Mutation_p.V73M	NM_000870	NP_000861	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform b	73	Helical; Name=2; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AAGGGCATCACCAGCACCGAA	0.408													0	0	0	0.001984	0	5	66										T	147928367	C	T	147928367	3	4	110	1	0	0	0	0	1	0	0	0	7449	507	18	2	1261	2	HTR4	5	147928367	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	7176854	147928367	32986893	155	33667										
ARSI	340075	broad.mit.edu	37	chr5	149677553	149677553	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ataagtgcccttgcgtcctcGgagcggccagttgctgcccc	12	15	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:149677553G>A	uc003lrv.2	-	2	1523	c.934C>T	c.(934-936)CGA>TGA	p.R312*		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	312						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGCGTCCTCGGAGCGGCCAG	0.592													0	0	0	0.004482	0	9	78										A	149677553	G	A	149677553	4	1	110	1	0	0	0	0	0	1	0	0	994	1124	39	2	779	2	ARSI	5	149677553	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1749186	149677553	31237707	156	33668										
DOCK2	1794	broad.mit.edu	37	chr5	169494582	169494582	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aatgagaagatcctgatgatGataaaccagtaccagagtga	10	6	0	7			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:169494582G>T	uc003maf.2	+	45	4616	c.4536G>T	c.(4534-4536)ATG>ATT	p.M1512I	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.M1004I|DOCK2_uc003mah.2_Missense_Mutation_p.M68I	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1512	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTGATGATGATAAACCAGT	0.498													1	0	5.18039e-06	0.00308	5.50003e-06	7	103										T	169494582	G	T	169494582	3	4	110	1	0	0	0	0	1	0	0	0	4687	1290	45	3	4714	3	DOCK2	5	169494582	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	19817029	169494582	11420678	157	33669										
SH3PXD2B	285590	broad.mit.edu	37	chr5	171765985	171765985	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttgcccgtcctgtcctgggcGcggccaggcccctctcctgg	13	18	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:171765985G>A	uc003mbr.2	-	13	2295	c.2124C>T	c.(2122-2124)CGC>CGT	p.R708R		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	708					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTCCTGGGCGCGGCCAGGCC	0.627													0	0	0	0.001984	0	6	40										A	171765985	G	A	171765985	2	1	110	1	0	0	0	0	0	0	0	1	14257	1074	38	2		2	SH3PXD2B	5	171765985	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2271403	171765985	9149275	158	33670										
UIMC1	51720	broad.mit.edu	37	chr5	176370462	176370462	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaggtagaaatagctacttCcttctcagcatcttccttgt	7	10	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:176370462C>T	uc011dfp.1	-	10	1638	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	UIMC1_uc003mfc.1_Missense_Mutation_p.E368K|UIMC1_uc003mfd.1_Missense_Mutation_p.E121K|UIMC1_uc003mfg.1_Missense_Mutation_p.E210K|UIMC1_uc003mfe.1_RNA|UIMC1_uc003mff.1_Missense_Mutation_p.E121K	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	491	Necessary for interaction with NR6A1 C- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ATAGCTACTTCCTTCTCAGCA	0.433													0	0	0	0.004482	0	8	100										T	176370462	C	T	176370462	3	4	110	1	0	0	0	0	1	0	0	0	16968	864	30	1	712	1	UIMC1	5	176370462	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4604477	176370462	4544798	159	33671										
ADAMTS2	9509	broad.mit.edu	37	chr5	178541064	178541064	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctctgtggcattggtgctgGaggcattgagagggacctcc	15	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr5:178541064G>T	uc003mjw.2	-	22	3440	c.3440C>A	c.(3439-3441)TCC>TAC	p.S1147Y	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1147					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ATTGGTGCTGGAGGCATTGAG	0.557													1	0	2.62699e-14	0.003163	2.90658e-14	12	135										T	178541064	G	T	178541064	3	4	110	1	0	0	0	0	1	0	0	0	265	1174	41	3	199	3	ADAMTS2	5	178541064	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2170602	178541064	2374196	160	33672										
MYLK4	340156	broad.mit.edu	37	chr6	2683270	2683270	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttaccttcaggtccaagtgGagaatgtacatctgatgcat	9	9	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:2683270G>C	uc003mty.3	-	7	969	c.672C>G	c.(670-672)CTC>CTG	p.L224L		NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	224	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				GGTCCAAGTGGAGAATGTACA	0.488													0	0	0	0.003954	0	21	124										C	2683270	G	C	2683270	2	2	110	1	0	0	0	0	0	0	0	1	10059	1161	41	1		1	MYLK4	6	2683270	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		2683270	168431797	161	33673										
HIST1H2AD	3013	broad.mit.edu	37	chr6	26199108	26199108	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttggccttgtggtgactctCagtcttcttggggagcagta	13	9	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:26199108C>G	uc003ngw.2	-	1	364	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	122					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				TGGTGACTCTCAGTCTTCTTG	0.488													0	0	0	0.003163	0	14	83										G	26199108	C	G	26199108	3	3	110	1	0	0	0	0	1	0	0	0	7131	835	29	1	32	1	HIST1H2AD	6	26199108	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	23515838	26199108	144915959	162	33674										
HIST1H2AG	8969	broad.mit.edu	37	chr6	27101102	27101102	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cgcatcatcccgcgtcatctCcaactggccatccgcaacga	7	18	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:27101102C>A	uc003niw.2	+	1	286	c.252C>A	c.(250-252)CTC>CTA	p.L84L	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	84					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CGCGTCATCTCCAACTGGCCA	0.627													1	0	1.10923e-09	0.00278	1.20853e-09	18	144										A	27101102	C	A	27101102	2	1	110	1	0	0	0	0	0	0	0	1	7133	842	30	3		3	HIST1H2AG	6	27101102	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	901994	27101102	144013965	163	33675										
HIST1H3H	8357	broad.mit.edu	37	chr6	27777942	27777942	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggcggctcggaagagcgctCcggccaccggcggtgtcaag	17	13	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:27777942C>T	uc003njm.2	+	1	101	c.91C>T	c.(91-93)CCG>TCG	p.P31S	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	31					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GAAGAGCGCTCCGGCCACCGG	0.657													0	0	0	0.001168	0	5	67										T	27777942	C	T	27777942	3	4	110	1	0	0	0	0	1	0	0	0	7162	855	30	1	93	1	HIST1H3H	6	27777942	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	676840	27777942	143337125	164	33676										
HLA-G	3135	broad.mit.edu	37	chr6	29797699	29797699	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gctgctgtgctgtggagaaaGaagagctcaggtaaggaagg	17	5	1	3	rs139184078		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:29797699G>A	uc003nnw.2	+	6	1180	c.1002G>A	c.(1000-1002)AAG>AAA	p.K334K	HLA-G_uc011dmb.1_Silent_p.K306K|HLA-G_uc003raj.3_Silent_p.K339K|HLA-G_uc003nnz.3_Silent_p.K242K|HLA-G_uc010jrn.2_Silent_p.K150K|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_RNA	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	334	Cytoplasmic (Potential).				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						TGTGGAGAAAGAAGAGCTCAG	0.572													0	0	0	0.00245	0	13	89										A	29797699	G	A	29797699	2	1	110	1	0	0	0	0	0	0	0	1	7212	933	33	1		1	HLA-G	6	29797699	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2019757	29797699	141317368	165	33677										
APOM	55937	broad.mit.edu	37	chr6	31625244	31625244	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggccagggttaccagcgctTtctcctctacagtgagtagg	12	11	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:31625244T>G	uc003nvl.2	+	4	504	c.431T>G	c.(430-432)TTT>TGT	p.F144C	APOM_uc003nvk.2_Missense_Mutation_p.F72C	NM_019101	NP_061974	O95445	APOM_HUMAN	apolipoprotein M	144					cholesterol efflux|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|negative regulation of plasma lipoprotein particle oxidation|reverse cholesterol transport	discoidal high-density lipoprotein particle|integral to plasma membrane|low-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	binding|lipid transporter activity				0						TACCAGCGCTTTCTCCTCTAC	0.562													0	0	0	0.001168	0	5	75										G	31625244	T	G	31625244	3	3	110	1	0	0	0	0	1	0	0	0	812	1841	64	5	445	5	APOM	6	31625244	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	1827545	31625244	139489823	166	33678										
HSPA1A	3303	broad.mit.edu	37	chr6	31785445	31785445	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctgggtcaggccccaccattGaggaggtagattaggggcct	15	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:31785445G>A	uc003nxj.2	+	1	2155	c.1912G>A	c.(1912-1914)GAG>AAG	p.E638K	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc003nxi.1_Missense_Mutation_p.E473K|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	638					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						CCCCACCATTGAGGAGGTAGA	0.547													0	0	0	0.00308	0	6	83										A	31785445	G	A	31785445	3	1	110	1	0	0	0	0	1	0	0	0	7408	1291	45	1	1914	1	HSPA1A	6	31785445	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	160201	31785445	139329622	167	33679										
CUL7	9820	broad.mit.edu	37	chr6	43012542	43012542	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	accagggcctcccagcaggtCttgcccagagcttgggcagc	13	15	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:43012542C>G	uc003otq.2	-	16	3423	c.3120G>C	c.(3118-3120)AAG>AAC	p.K1040N	CUL7_uc010jyg.2_Missense_Mutation_p.K319N|CUL7_uc011dvb.1_Missense_Mutation_p.K1124N|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1040					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCAGCAGGTCTTGCCCAGAG	0.597													0	0	0	0.00308	0	7	97										G	43012542	C	G	43012542	3	3	110	1	0	0	0	0	1	0	0	0	4060	912	32	1	2020	1	CUL7	6	43012542	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	11227097	43012542	128102525	168	33680										
MED23	9439	broad.mit.edu	37	chr6	131923477	131923477	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taaactgcggttgtacctctGagctacctaatgctgttata	8	9	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:131923477G>T	uc003qcs.1	-	17	2150	c.1976C>A	c.(1975-1977)TCA>TAA	p.S659*	MED23_uc003qcq.2_Nonsense_Mutation_p.S665*|MED23_uc011eca.1_Nonsense_Mutation_p.S300*|MED23_uc003qct.1_Nonsense_Mutation_p.S665*|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	659					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TTGTACCTCTGAGCTACCTAA	0.403													1	0	5.18039e-06	0.00308	5.50003e-06	6	70										T	131923477	G	T	131923477	4	4	110	1	0	0	0	0	0	1	0	0	9441	1294	45	3	2189	3	MED23	6	131923477	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	88910935	131923477	39191590	169	33681										
VIP	7432	broad.mit.edu	37	chr6	153073417	153073417	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tacagggcaccttctgctctCaggtaagttccctttcaatt	7	12	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:153073417C>T	uc003qpe.2	+	2	277	c.105C>T	c.(103-105)CTC>CTT	p.L35L	VIP_uc003qpf.2_Silent_p.L35L|VIP_uc010kjd.2_Silent_p.L35L	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	35					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		CTTCTGCTCTCAGGTAAGTTC	0.423													0	0	0	0.001168	0	6	41										T	153073417	C	T	153073417	2	4	110	1	0	0	0	0	0	0	0	1	17164	813	29	1		1	VIP	6	153073417	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	21149940	153073417	18041650	170	33682										
SLC22A2	6582	broad.mit.edu	37	chr6	160663435	160663435	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aatttttagccattgtagatCtaagagggaaaagaacagta	9	4	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:160663435C>G	uc003qtf.2	-	8	1450	c.1280_splice	c.e8-1	p.D427_splice	SLC22A2_uc003qte.1_Splice_Site_p.D427_splice	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2						body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CATTGTAGATCTAAGAGGGAA	0.448													0	0	0	0.004482	0	8	65										G	160663435	C	G	160663435	5	3	110	1	0	0	0	0	0	0	1	0	14450	927	32	1	404	1	SLC22A2	6	160663435	Splice_Site	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	7590018	160663435	10451632	171	33683										
RNASET2	8635	broad.mit.edu	37	chr6	167352457	167352457	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgggagttgagcgcatccacCtgggcggcgcaggtcccatg	16	12	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr6:167352457C>T	uc003qve.2	-	6	779	c.372G>A	c.(370-372)CAG>CAA	p.Q124Q	RNASET2_uc003qvh.2_Intron|RNASET2_uc003qvf.2_Silent_p.Q32Q|RNASET2_uc003qvg.2_Silent_p.Q61Q|RNASET2_uc003qvi.1_Missense_Mutation_p.R12K	NM_003730	NP_003721	O00584	RNT2_HUMAN	ribonuclease T2 precursor	124					RNA catabolic process	extracellular region	ribonuclease T2 activity|RNA binding				0		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;1.53e-19)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00665)		GCGCATCCACCTGGGCGGCGC	0.498													0	0	0	0.001368	0	9	110										T	167352457	C	T	167352457	2	4	110	1	0	0	0	0	0	0	0	1	13418	680	24	2		2	RNASET2	6	167352457	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6689022	167352457	3762610	172	33684										
SUN1	23353	broad.mit.edu	37	chr7	896032	896032	+	Frame_Shift_Del	DEL	C	C	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agaacagaccaagcaaaaaaCaatcaggtaggaggatttgg							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:896032delC	uc011jvp.1	+	13	1467	c.1388delC	c.(1387-1389)ACAfs	p.T463fs	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Frame_Shift_Del_p.T380fs|SUN1_uc011jvq.1_Frame_Shift_Del_p.T360fs|SUN1_uc003sjg.2_Frame_Shift_Del_p.T368fs|SUN1_uc011jvr.1_Frame_Shift_Del_p.T261fs|SUN1_uc003sji.2_Frame_Shift_Del_p.T301fs|SUN1_uc003sjk.2_Frame_Shift_Del_p.T102fs	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	490	Perinuclear space.|Potential.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						AAGCAAAAAACAATCAGGTAG	0.418																		11	121	---	---								-	896032	C	-	896032	7	5	110	1	0	1	0	1	0	0	0	0	15388	478	17	0	1617	0	SUN1	7	896032	Frame_Shift_Del	DEL	C	TCGA-GD-A3OP-01A-21D-A21Z-08		896032	158242631	173	33685										
EIF2AK1	27102	broad.mit.edu	37	chr7	6080762	6080762	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctgattttcagtgtcagattCtccaaagcgtttttcttttt	6	8	4	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:6080762C>T	uc003spp.2	-	9	1026	c.880G>A	c.(880-882)GAA>AAA	p.E294K	EIF2AK1_uc003spq.2_Missense_Mutation_p.E293K|EIF2AK1_uc011jwm.1_Missense_Mutation_p.E170K|EIF2AK1_uc003spr.1_Missense_Mutation_p.E86K	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	294	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		GTGTCAGATTCTCCAAAGCGT	0.408													0	0	0	0.003163	0	15	125										T	6080762	C	T	6080762	3	4	110	1	0	0	0	0	1	0	0	0	4996	922	32	1	1040	1	EIF2AK1	7	6080762	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5184730	6080762	153057901	174	33686										
RAC1	5879	broad.mit.edu	37	chr7	6431604	6431604	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tagatggaaaaccggtgaatCtgggcttatgggatacagct	13	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:6431604C>G	uc003spx.2	+	3	398	c.157C>G	c.(157-159)CTG>GTG	p.L53V	RAC1_uc003spw.2_Missense_Mutation_p.L53V	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	53					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	ACCGGTGAATCTGGGCTTATG	0.413													0	0	0	0.006214	0	9	129										G	6431604	C	G	6431604	3	3	110	1	0	0	0	0	1	0	0	0	12974	912	32	1	167	1	RAC1	7	6431604	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	350842	6431604	152707059	175	33687										
MEOX2	4223	broad.mit.edu	37	chr7	15652020	15652020	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctctgtttatatcataagtGcgcatgctctgagctgtggt	10	9	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:15652020G>A	uc003stc.2	-	3	1188	c.907C>T	c.(907-909)CAC>TAC	p.H303Y	MEOX2_uc011jxw.1_Missense_Mutation_p.H303Y	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	303					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TATCATAAGTGCGCATGCTCT	0.478													0	0	0	0.004482	0	8	64										A	15652020	G	A	15652020	3	1	110	1	0	0	0	0	1	0	0	0	9474	1319	46	2	11	2	MEOX2	7	15652020	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9220416	15652020	143486643	176	33688										
AHR	196	broad.mit.edu	37	chr7	17382605	17382605	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taaataacataaataacactCagactaccacacatcttcag	2	11	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:17382605C>T	uc011jxz.1	+	11	3077	c.2464C>T	c.(2464-2466)CAG>TAG	p.Q822*	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	822				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAATAACACTCAGACTACCAC	0.368													0	0	0	0.00278	0	20	135										T	17382605	C	T	17382605	4	4	110	1	0	0	0	0	0	1	0	0	416	827	29	1	2506	1	AHR	7	17382605	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1730585	17382605	141756058	177	33689										
PDE1C	5137	broad.mit.edu	37	chr7	31862716	31862716	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccttggccctccatctctccCgattgatgtgcaccacttcc	6	18	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:31862716C>T	uc003tcm.1	-	14	2022	c.1553G>A	c.(1552-1554)CGG>CAG	p.R518Q	PDE1C_uc003tcn.1_Missense_Mutation_p.R518Q|PDE1C_uc003tco.1_Missense_Mutation_p.R578Q|PDE1C_uc003tcr.2_Missense_Mutation_p.R518Q|PDE1C_uc003tcs.2_Missense_Mutation_p.R518Q	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	518	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CCATCTCTCCCGATTGATGTG	0.473													0	0	0	0.000978	0	11	185										T	31862716	C	T	31862716	3	4	110	1	0	0	0	0	1	0	0	0	11635	652	23	2	367	2	PDE1C	7	31862716	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	14480111	31862716	127275947	178	33690										
MYO1G	64005	broad.mit.edu	37	chr7	45016619	45016619	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggcagctcctggtaggggttCacggacaccagcacctcacc	12	15	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:45016619C>T	uc003tmh.2	-	2	291	c.147G>A	c.(145-147)GTG>GTA	p.V49V	MYO1G_uc003tmg.2_5'Flank|MYO1G_uc010kym.2_Intron|MYO1G_uc003tmi.1_5'UTR|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	49	Myosin head-like.		V -> M (in allele HA-2M; the HA-2V allele constitute the HA-2 epitope while HA-2M is not recognized by HA-2 cytotoxic T lymphocytes).			myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GGTAGGGGTTCACGGACACCA	0.627													0	0	0	0.004007	0	13	94										T	45016619	C	T	45016619	2	4	110	1	0	0	0	0	0	0	0	1	10074	813	29	1		1	MYO1G	7	45016619	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	13153903	45016619	114122044	179	33691										
WBSCR17	64409	broad.mit.edu	37	chr7	71036334	71036334	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcttcggtgaaattggtcttCtggatcctggcatggatgta	12	7	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:71036334C>G	uc003tvy.2	+	6	1027	c.1027C>G	c.(1027-1029)CTG>GTG	p.L343V	WBSCR17_uc003tvz.2_Missense_Mutation_p.L42V	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	343	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AATTGGTCTTCTGGATCCTGG	0.498													0	0	0	0.008291	0	9	154										G	71036334	C	G	71036334	3	3	110	1	0	0	0	0	1	0	0	0	17261	912	32	1	1049	1	WBSCR17	7	71036334	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	26019715	71036334	88102329	180	33692										
CALCR	799	broad.mit.edu	37	chr7	93108727	93108727	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catttgtactgtgcatccatCatcttctttcgtcctacgac	5	13	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:93108727C>T	uc003umv.1	-	4	459	c.198G>A	c.(196-198)ATG>ATA	p.M66I	CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Missense_Mutation_p.M48I|CALCR_uc003umw.2_Missense_Mutation_p.M48I	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	48	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GTGCATCCATCATCTTCTTTC	0.413													0	0	0	0.002299	0	16	209										T	93108727	C	T	93108727	3	4	110	1	0	0	0	0	1	0	0	0	2579	826	29	1	1376	1	CALCR	7	93108727	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	22072393	93108727	66029936	181	33693										
STAG3	10734	broad.mit.edu	37	chr7	99796487	99796487	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcttctaccctgagtgcgaGataagaatgatgggtggaag	13	7	2	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:99796487G>A	uc003utx.1	+	14	1529	c.1374G>A	c.(1372-1374)GAG>GAA	p.E458E	STAG3_uc010lgs.1_Silent_p.E246E|STAG3_uc011kjk.1_Silent_p.E400E|STAG3_uc003uub.1_5'Flank	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	458					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGAGTGCGAGATAAGAATGA	0.547													0	0	0	0.000978	0	9	125										A	99796487	G	A	99796487	2	1	110	1	0	0	0	0	0	0	0	1	15243	933	33	1		1	STAG3	7	99796487	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6687760	99796487	59342176	182	33694										
CTTNBP2	83992	broad.mit.edu	37	chr7	117431578	117431578	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttgagttgggggtgtggtgGagaaggagtttgggagagcc	21	3	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:117431578G>A	uc003vjf.2	-	4	1764	c.1672C>T	c.(1672-1674)CCA>TCA	p.P558S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	558	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGGTGTGGTGGAGAAGGAGTT	0.502													0	0	0	0.008291	0	9	140										A	117431578	G	A	117431578	3	1	110	1	0	0	0	0	1	0	0	0	4045	1174	41	1	3399	1	CTTNBP2	7	117431578	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	17635091	117431578	41707085	183	33695										
CADPS2	93664	broad.mit.edu	37	chr7	122130198	122130198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttctgggtttgaattgcagGaactggtttatatgattgac	11	4	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:122130198G>A	uc010lkp.2	-	11	1952	c.1789C>T	c.(1789-1791)CCT>TCT	p.P597S	CADPS2_uc003vkg.3_Missense_Mutation_p.P297S|CADPS2_uc010lkq.2_Missense_Mutation_p.P597S	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	597					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TGAATTGCAGGAACTGGTTTA	0.368													0	0	0	0.001168	0	5	83										A	122130198	G	A	122130198	3	1	110	1	0	0	0	0	1	0	0	0	2571	1174	41	1	2225	1	CADPS2	7	122130198	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4698620	122130198	37008465	184	33696										
POT1	25913	broad.mit.edu	37	chr7	124503433	124503433	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaatgatgctccgtccacttCtgctttgcccaagagctgac	8	13	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:124503433C>T	uc003vlm.2	-	8	1118	c.517G>A	c.(517-519)GAA>AAA	p.E173K	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.E42K|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	173					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						CCGTCCACTTCTGCTTTGCCC	0.388													0	0	0	0.006122	0	14	96										T	124503433	C	T	124503433	3	4	110	1	0	0	0	0	1	0	0	0	12260	922	32	1	1435	1	POT1	7	124503433	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2373235	124503433	34635230	185	33697										
SMO	6608	broad.mit.edu	37	chr7	128845541	128845541	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcttctttgtgggcagcattGgctggctggcccagttcatg	14	10	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:128845541G>T	uc003vor.2	+	4	1118	c.838G>T	c.(838-840)GGC>TGC	p.G280C	SMO_uc003vos.2_5'Flank	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	280	Helical; Name=2; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						GGGCAGCATTGGCTGGCTGGC	0.582			Mis		skin basal cell 								1	0	4.26978e-12	0.00333	4.70335e-12	19	79										T	128845541	G	T	128845541	3	4	110	1	0	0	0	0	1	0	0	0	14800	1348	47	4	852	4	SMO	7	128845541	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4342108	128845541	30293122	186	33698										
LUC7L2	51631	broad.mit.edu	37	chr7	139026236	139026236	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atcgcgacaccgcggcctatCggtaccttgtgaaggctttc	11	13	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:139026236C>G	uc011kqt.1	+	1	340	c.106C>G	c.(106-108)CGG>GGG	p.R36G	LUC7L2_uc011kqs.1_Intron|C7orf55_uc003vuw.3_Missense_Mutation_p.R36G	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	Error:Variant_position_missing_in_Q9Y383_after_alignment							enzyme binding|metal ion binding				0	Melanoma(164;0.242)					CGCGGCCTATCGGTACCTTGT	0.657											OREG0018357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	76										G	139026236	C	G	139026236	3	3	110	1	0	0	0	0	1	0	0	0	9083	875	31	1		1	LUC7L2	7	139026236	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	10180695	139026236	20112427	187	33699										
SLC37A3	84255	broad.mit.edu	37	chr7	140051177	140051177	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	attcggctcatattcgtcttCattttcaccaccattaatta	3	11	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:140051177C>T	uc003vvo.2	-	9	944	c.778G>A	c.(778-780)GAA>AAA	p.E260K	SLC37A3_uc003vvp.2_Missense_Mutation_p.E260K|SLC37A3_uc010lnh.2_Missense_Mutation_p.E260K|SLC37A3_uc011kqz.1_RNA|SLC37A3_uc011kra.1_3'UTR|SLC37A3_uc011krb.1_3'UTR	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	260					carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					TATTCGTCTTCATTTTCACCA	0.378													0	0	0	0.00245	0	10	127										T	140051177	C	T	140051177	3	4	110	1	0	0	0	0	1	0	0	0	14599	835	29	1	883	1	SLC37A3	7	140051177	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1024941	140051177	19087486	188	33700										
SLC37A3	84255	broad.mit.edu	37	chr7	140051237	140051237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcaaagttttcttctgcctCaatacccgagagacctaaaa	5	11	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:140051237C>G	uc003vvo.2	-	9	884	c.718G>C	c.(718-720)GAG>CAG	p.E240Q	SLC37A3_uc003vvp.2_Missense_Mutation_p.E240Q|SLC37A3_uc010lnh.2_Missense_Mutation_p.E240Q|SLC37A3_uc011kqz.1_RNA|SLC37A3_uc011kra.1_3'UTR|SLC37A3_uc011krb.1_3'UTR	NM_207113	NP_996996	Q8NCC5	SPX3_HUMAN	solute carrier family 37 (glycerol-3-phosphate	240					carbohydrate transport|transmembrane transport	integral to membrane				ovary(3)	3	Melanoma(164;0.0142)					TCTTCTGCCTCAATACCCGAG	0.229													0	0	0	0.009096	0	4	82										G	140051237	C	G	140051237	3	3	110	1	0	0	0	0	1	0	0	0	14599	835	29	1	943	1	SLC37A3	7	140051237	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	60	140051237	19087426	189	33701										
BRAF	673	broad.mit.edu	37	chr7	140494157	140494157	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tatgcacattgggagctgatGaggatcggtctcgttgccca	13	9	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:140494157G>A	uc003vwc.3	-	8	1152	c.1091C>T	c.(1090-1092)TCA>TTA	p.S364L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	364					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGGAGCTGATGAGGATCGGTC	0.408		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				0	0	0	0.004007	0	13	123										A	140494157	G	A	140494157	3	1	110	1	0	0	0	0	1	0	0	0	1496	1294	45	1	1253	1	BRAF	7	140494157	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	442920	140494157	18644506	190	33702										
C7orf34	135927	broad.mit.edu	37	chr7	142636653	142636653	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccaggacaggaatggggcagGaggtgcacggatcctgctgg	18	9	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:142636653G>A	uc003wca.2	+	1	51	c.10G>A	c.(10-12)GAG>AAG	p.E4K		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	Error:Variant_position_missing_in_Q96L11_after_alignment						extracellular region					0	Melanoma(164;0.059)					AATGGGGCAGGAGGTGCACGG	0.627													0	0	0	0.001984	0	5	36										A	142636653	G	A	142636653	3	1	110	1	0	0	0	0	1	0	0	0	2389	1175	41	1	12	1	C7orf34	7	142636653	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2142496	142636653	16502010	191	33703										
FASTK	10922	broad.mit.edu	37	chr7	150777000	150777000	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcgaagcatggagttgggtGatggagaccctgaggggcag	18	7	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:150777000G>A	uc003wix.1	-	2	190	c.92C>T	c.(91-93)TCA>TTA	p.S31L	FASTK_uc003wiw.1_Intron|FASTK_uc003wiy.1_Intron|FASTK_uc003wiz.1_Missense_Mutation_p.S31L|FASTK_uc003wja.1_5'UTR	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	31					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		GGAGTTGGGTGATGGAGACCC	0.582													0	0	0	0.001168	0	5	9										A	150777000	G	A	150777000	3	1	110	1	0	0	0	0	1	0	0	0	5684	1294	45	1	1593	1	FASTK	7	150777000	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	8140347	150777000	8361663	192	33704										
RHEB	6009	broad.mit.edu	37	chr7	151188091	151188091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caacaaattgaatcgtcaatGaggatttccctataaaagag	7	7	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr7:151188091G>A	uc003wkh.1	-	2	475	c.62C>T	c.(61-63)TCA>TTA	p.S21L		NM_005614	NP_005605	Q15382	RHEB_HUMAN	Ras homolog enriched in brain precursor	21	GTP.				cell cycle arrest|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|metal ion binding|protein binding			large_intestine(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00306)	UCEC - Uterine corpus endometrioid carcinoma (81;0.174)		AATCGTCAATGAGGATTTCCC	0.323													0	0	0	0.009096	0	4	69										A	151188091	G	A	151188091	3	1	110	1	0	0	0	0	1	0	0	0	13328	1294	45	1	520	1	RHEB	7	151188091	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	411091	151188091	7950572	193	33705										
LZTS1	11178	broad.mit.edu	37	chr8	20110556	20110556	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcagcgccgcggccgctcctCgtaggccaggctggaggcaa	16	15	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:20110556C>T	uc003wzr.2	-	2	997	c.886G>A	c.(886-888)GAG>AAG	p.E296K	LZTS1_uc010ltg.1_Missense_Mutation_p.E296K	NM_021020	NP_066300	Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	296	Potential.				cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GGCCGCTCCTCGTAGGCCAGG	0.677													0	0	0	0.001984	0	5	47										T	20110556	C	T	20110556	3	4	110	1	0	0	0	0	1	0	0	0	9138	893	31	1	912	1	LZTS1	8	20110556	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		20110556	126253466	194	33706										
NEFM	4741	broad.mit.edu	37	chr8	24776021	24776021	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccgtcactcaaaaggttgaaGagcatgaagagacctttgag	11	8	2	5	rs150229714		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:24776021G>A	uc003xed.3	+	3	2686	c.2653G>A	c.(2653-2655)GAG>AAG	p.E885K	NEFM_uc011lac.1_Missense_Mutation_p.E667K|NEFM_uc010lue.2_Missense_Mutation_p.E509K	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	885	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AAAGGTTGAAGAGCATGAAGA	0.428													0	0	0	0.006214	0	7	140										A	24776021	G	A	24776021	3	1	110	1	0	0	0	0	1	0	0	0	10316	943	33	1	2663	1	NEFM	8	24776021	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4665465	24776021	121588001	195	33707										
GNRH1	2796	broad.mit.edu	37	chr8	25280738	25280738	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atcaatcaaattttcggcatCtctctttcctccagggcgca	6	13	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:25280738C>T	uc003xem.3	-	2	950	c.109G>A	c.(109-111)GAT>AAT	p.D37N	PPP2R2A_uc003xek.2_Intron|GNRH1_uc003xen.3_Missense_Mutation_p.D37N	NM_001083111	NP_001076580	P01148	GON1_HUMAN	gonadotropin-releasing hormone 1 precursor	37					cell-cell signaling|multicellular organismal development|negative regulation of cell proliferation|signal transduction	soluble fraction	gonadotropin hormone-releasing hormone activity			large_intestine(1)	1		all_cancers(63;0.0423)|Ovarian(32;0.000626)|all_epithelial(46;0.0186)|Hepatocellular(4;0.114)|Breast(100;0.14)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0201)|Epithelial(17;1.25e-12)|Colorectal(74;0.0113)|COAD - Colon adenocarcinoma(73;0.0385)		TTTTCGGCATCTCTCTTTCCT	0.408													0	0	0	0.001855	0	11	142										T	25280738	C	T	25280738	3	4	110	1	0	0	0	0	1	0	0	0	6547	913	32	1	181	1	GNRH1	8	25280738	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	504717	25280738	121083284	196	33708										
KIF13B	23303	broad.mit.edu	37	chr8	28974498	28974498	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgagggcagccatgcaccgcGgagtcccaggaggcttctgc	15	13	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:28974498G>A	uc003xhh.3	-	31	3746	c.3687C>T	c.(3685-3687)TCC>TCT	p.S1229S	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1229					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CATGCACCGCGGAGTCCCAGG	0.577													0	0	0	0.001168	0	5	101										A	28974498	G	A	28974498	2	1	110	1	0	0	0	0	0	0	0	1	8275	1103	39	2		2	KIF13B	8	28974498	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3693760	28974498	117389524	197	33709										
CHD7	55636	broad.mit.edu	37	chr8	61735145	61735145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctatgagatatatttgaaagGaatccatggcccttttttag	8	6	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:61735145G>A	uc003xue.2	+	12	3518	c.3041G>A	c.(3040-3042)GGA>GAA	p.G1014E	CHD7_uc003xuf.2_Missense_Mutation_p.G127E	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1014	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TATTTGAAAGGAATCCATGGC	0.408													0	0	0	0.006122	0	15	223										A	61735145	G	A	61735145	3	1	110	1	0	0	0	0	1	0	0	0	3330	1174	41	1	3083	1	CHD7	8	61735145	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	32760647	61735145	84628877	198	33710										
CHD7	55636	broad.mit.edu	37	chr8	61749458	61749458	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gattctccaaacctgattctGataggtttgttttcctcctg	7	10	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:61749458G>A	uc003xue.2	+	17	4549	c.4072G>A	c.(4072-4074)GAT>AAT	p.D1358N		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1358	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACCTGATTCTGATAGGTTTGT	0.483													0	0	0	0.00361	0	53	198										A	61749458	G	A	61749458	3	1	110	1	0	0	0	0	1	0	0	0	3330	1290	45	1	4134	1	CHD7	8	61749458	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	14313	61749458	84614564	199	33711										
TRIM55	84675	broad.mit.edu	37	chr8	67040613	67040613	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cgattccgctgcccatcctgTagacatgaagtggttttgga	11	10	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:67040613T>C	uc003xvv.2	+	2	469	c.243T>C	c.(241-243)TGT>TGC	p.C81C	TRIM55_uc003xvu.2_Silent_p.C81C|TRIM55_uc003xvw.2_Silent_p.C81C|TRIM55_uc003xvx.2_Silent_p.C81C	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	81						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GCCCATCCTGTAGACATGAAG	0.498													0	0	0	0.00361	0	61	197										C	67040613	T	C	67040613	2	2	110	1	0	0	0	0	0	0	0	1	16526	1644	57	5		5	TRIM55	8	67040613	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	5291155	67040613	79323409	200	33712										
SLCO5A1	81796	broad.mit.edu	37	chr8	70744345	70744345	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggccgccgaccccggccgccGaagtagctgacgaacaccac	12	18	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:70744345G>A	uc003xyl.2	-	2	1271	c.564C>T	c.(562-564)TTC>TTT	p.F188F	SLCO5A1_uc010lzb.2_Silent_p.F188F|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.F188F|SLCO5A1_uc010lzc.2_Silent_p.F188F	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	188	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCCGGCCGCCGAAGTAGCTGA	0.642													0	0	0	0.001168	0	4	76										A	70744345	G	A	70744345	2	1	110	1	0	0	0	0	0	0	0	1	14731	1049	37	1		1	SLCO5A1	8	70744345	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3703732	70744345	75619677	201	33713										
NBN	4683	broad.mit.edu	37	chr8	90990452	90990452	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaaatacataatatacctttCaatttgtggaggctgcttct	6	7	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:90990452C>T	uc003yej.1	-	5	690	c.580G>A	c.(580-582)GAA>AAA	p.E194K	NBN_uc003yei.1_Missense_Mutation_p.E112K|NBN_uc011lgb.1_Missense_Mutation_p.E194K	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	194					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			ATATACCTTTCAATTTGTGGA	0.323								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.000602	0	5	71										T	90990452	C	T	90990452	3	4	110	1	0	0	0	0	1	0	0	0	10191	835	29	1	1732	1	NBN	8	90990452	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	20246107	90990452	55373570	202	33714										
NBN	4683	broad.mit.edu	37	chr8	90993657	90993657	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catcccccgacttcaaagttCgggaaaagccattctgcatt	7	13	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:90993657C>T	uc003yej.1	-	3	376	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	NBN_uc003yei.1_Missense_Mutation_p.R7Q|NBN_uc011lgb.1_Missense_Mutation_p.R89Q	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	89					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			CTTCAAAGTTCGGGAAAAGCC	0.333								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				0	0	0	0.004482	0	8	173										T	90993657	C	T	90993657	3	4	110	1	0	0	0	0	1	0	0	0	10191	884	31	1	2054	1	NBN	8	90993657	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3205	90993657	55370365	203	33715										
SLC26A7	115111	broad.mit.edu	37	chr8	92374633	92374633	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgctttgctgccaatgtggGactgctgtttggtgttgttt	13	6	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:92374633G>C	uc003yex.2	+	13	1645	c.1367G>C	c.(1366-1368)GGA>GCA	p.G456A	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.G456A|SLC26A7_uc003yfa.2_Missense_Mutation_p.G456A	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	456	Helical; (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GCCAATGTGGGACTGCTGTTT	0.393													0	0	0	0.003755	0	27	302										C	92374633	G	C	92374633	3	2	110	1	0	0	0	0	1	0	0	0	14522	1174	41	1	1409	1	SLC26A7	8	92374633	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1380976	92374633	53989389	204	33716										
ESRP1	54845	broad.mit.edu	37	chr8	95658419	95658419	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtactattacctgaatgcttCtattccttttttgatcttcg	5	9	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:95658419C>A	uc003ygq.3	+	4	582	c.399C>A	c.(397-399)TTC>TTA	p.F133L	ESRP1_uc003ygr.3_Missense_Mutation_p.F133L|ESRP1_uc003ygs.3_Missense_Mutation_p.F133L|ESRP1_uc003ygt.3_Missense_Mutation_p.F133L|ESRP1_uc003ygu.3_Missense_Mutation_p.F133L|ESRP1_uc003ygv.2_5'UTR|ESRP1_uc003ygw.2_5'UTR	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	133					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						CTGAATGCTTCTATTCCTTTT	0.363													1	0	0.000157383	0.00308	0.000163955	7	119										A	95658419	C	A	95658419	3	1	110	1	0	0	0	0	1	0	0	0	5258	912	32	3	413	3	ESRP1	8	95658419	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3283786	95658419	50705603	205	33717										
MTDH	92140	broad.mit.edu	37	chr8	98718973	98718973	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggaaccaattcctgatgatCaaaaggtgagtataagagat	10	5	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:98718973C>T	uc003yhz.2	+	8	1595	c.1267C>T	c.(1267-1269)CAA>TAA	p.Q423*	MTDH_uc010mbf.2_RNA	NM_178812	NP_848927	Q86UE4	LYRIC_HUMAN	metadherin	423	Lung-homing for mammary tumors (By similarity).|Cytoplasmic (Potential).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			liver(1)|central_nervous_system(1)	2	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TCCTGATGATCAAAAGGTGAG	0.323													0	0	0	0.004482	0	8	209										T	98718973	C	T	98718973	4	4	110	1	0	0	0	0	0	1	0	0	9917	827	29	1	1297	1	MTDH	8	98718973	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3060554	98718973	47645049	206	33718										
LRP12	29967	broad.mit.edu	37	chr8	105511661	105511661	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaattgtggaaccacaagctCtgtaactttcaatattcttg	7	8	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:105511661C>T	uc003yma.2	-	4	454	c.359G>A	c.(358-360)AGA>AAA	p.R120K	LRP12_uc003ymb.2_Missense_Mutation_p.R101K	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	120	Extracellular (Potential).|CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ACCACAAGCTCTGTAACTTTC	0.373													0	0	0	0.001984	0	7	102										T	105511661	C	T	105511661	3	4	110	1	0	0	0	0	1	0	0	0	8954	913	32	1	2236	1	LRP12	8	105511661	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6792688	105511661	40852361	207	33719										
PKHD1L1	93035	broad.mit.edu	37	chr8	110487424	110487424	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctctgattccaaatgcaaatCacattaactggtattttaaa	4	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:110487424C>T	uc003yne.2	+	51	8787	c.8683C>T	c.(8683-8685)CAC>TAC	p.H2895Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2895	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAATGCAAATCACATTAACTG	0.338										HNSCC(38;0.096)			0	0	0	0.004656	0	23	35										T	110487424	C	T	110487424	3	4	110	1	0	0	0	0	1	0	0	0	11972	826	29	1	8885	1	PKHD1L1	8	110487424	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4975763	110487424	35876598	208	33720										
PKHD1L1	93035	broad.mit.edu	37	chr8	110495274	110495274	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcaatatataaaactaagctCtcagaaactgcatttgcagg	6	8	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:110495274C>G	uc003yne.2	+	57	9620	c.9516C>G	c.(9514-9516)CTC>CTG	p.L3172L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3172	Extracellular (Potential).|G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAACTAAGCTCTCAGAAACTG	0.388										HNSCC(38;0.096)			0	0	0	0.001984	0	5	38										G	110495274	C	G	110495274	2	3	110	1	0	0	0	0	0	0	0	1	11972	900	32	1		1	PKHD1L1	8	110495274	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	7850	110495274	35868748	209	33721										
CSMD3	114788	broad.mit.edu	37	chr8	114326926	114326926	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttctgctattattacccatGtgcagtttgcaccatttgga	7	10	1	0	rs111400281		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:114326926G>T	uc003ynu.2	-	2	434	c.275C>A	c.(274-276)ACA>AAA	p.T92K	CSMD3_uc003ynt.2_Missense_Mutation_p.T52K|CSMD3_uc011lhx.1_Missense_Mutation_p.T92K|CSMD3_uc010mcx.1_Missense_Mutation_p.T92K|CSMD3_uc003ynx.3_Missense_Mutation_p.T92K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	92	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TATTACCCATGTGCAGTTTGC	0.343										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	4.68919e-08	0.008291	5.06473e-08	11	150										T	114326926	G	T	114326926	3	4	110	1	0	0	0	0	1	0	0	0	3946	1377	48	4	11128	4	CSMD3	8	114326926	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3831652	114326926	32037096	210	33722										
EIF2C2	27161	broad.mit.edu	37	chr8	141549523	141549523	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttctagcttgatacaggcctCacggatggccagcaactcgt	10	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr8:141549523C>A	uc003yvn.2	-	16	2105	c.2065G>T	c.(2065-2067)GAG>TAG	p.E689*	EIF2C2_uc010men.2_Nonsense_Mutation_p.E612*|EIF2C2_uc010meo.2_Nonsense_Mutation_p.E689*	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	689	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			ATACAGGCCTCACGGATGGCC	0.567													1	0	2.17888e-05	0.006214	2.30841e-05	6	111										A	141549523	C	A	141549523	4	1	110	1	0	0	0	0	0	1	0	0	5006	835	29	3	530	3	EIF2C2	8	141549523	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	27222597	141549523	4814499	211	33723										
C9orf46	55848	broad.mit.edu	37	chr9	5358254	5358254	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgatttcatttgtctatgaaGaatctactctgttcctttct	5	8	5	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:5358254G>C	uc003zjc.2	-	6	633	c.429C>G	c.(427-429)TTC>TTG	p.F143L	C9orf46_uc003zjd.2_Missense_Mutation_p.F143L	NM_018465	NP_060935	Q9HBL7	CI046_HUMAN	hypothetical protein LOC55848	143						integral to membrane				ovary(1)	1	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.00106)|Lung(218;0.125)		TGTCTATGAAGAATCTACTCT	0.338													0	0	0	0.004482	0	6	112										C	5358254	G	C	5358254	3	2	110	1	0	0	0	0	1	0	0	0	2484	933	33	1	18	1	C9orf46	9	5358254	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		5358254	135855177	212	33724										
CNTLN	54875	broad.mit.edu	37	chr9	17457539	17457539	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagaagctaaatttggatttGgctgggcttcggaaagaaaa	12	4	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:17457539G>A	uc003zmz.2	+	19	3155	c.3129G>A	c.(3127-3129)TTG>TTA	p.L1043L	CNTLN_uc003zmy.2_Silent_p.L1044L|CNTLN_uc010mio.2_Silent_p.L723L	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1044	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		ATTTGGATTTGGCTGGGCTTC	0.254													0	0	0	0.000602	0	4	62										A	17457539	G	A	17457539	2	1	110	1	0	0	0	0	0	0	0	1	3639	1339	47	2		2	CNTLN	9	17457539	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	12099285	17457539	123755892	213	33725										
ADAMTSL1	92949	broad.mit.edu	37	chr9	18776929	18776929	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtggtgctgcgctgcccggCgcgcagggtccgcaagcccc	17	16	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:18776929C>T	uc003zne.3	+	19	2829	c.2702C>T	c.(2701-2703)GCG>GTG	p.A901V		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	901	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCTGCCCGGCGCGCAGGGTC	0.652													0	0	0	0.009096	0	4	39										T	18776929	C	T	18776929	3	4	110	1	0	0	0	0	1	0	0	0	274	768	27	2	2780	2	ADAMTSL1	9	18776929	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1319390	18776929	122436502	214	33726										
DDX58	23586	broad.mit.edu	37	chr9	32500809	32500809	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagaatgaactaacctgcatGgtctagggcatccaaaaagc	9	9	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:32500809G>A	uc003zra.2	-	2	393	c.235C>T	c.(235-237)CAT>TAT	p.H79Y	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_5'UTR	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	79	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TAACCTGCATGGTCTAGGGCA	0.418													0	0	0	0.001984	0	6	114										A	32500809	G	A	32500809	3	1	110	1	0	0	0	0	1	0	0	0	4375	1348	47	2	2610	2	DDX58	9	32500809	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	13723880	32500809	108712622	215	33727										
FRMD3	257019	broad.mit.edu	37	chr9	86004545	86004545	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttctctgggtccacatagcGaatgccaaagtagtccttct	8	12	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:86004545G>A	uc004ams.1	-	2	428	c.226C>T	c.(226-228)CGC>TGC	p.R76C	FRMD3_uc004amr.1_Missense_Mutation_p.R62C	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	76	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TCCACATAGCGAATGCCAAAG	0.498													0	0	0	0.00308	0	5	95										A	86004545	G	A	86004545	3	1	110	1	0	0	0	0	1	0	0	0	6050	1058	37	1	1619	1	FRMD3	9	86004545	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	53503736	86004545	55208886	216	33728										
NTRK2	4915	broad.mit.edu	37	chr9	87338522	87338522	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aatctggccgcacctaacctCactgtggaggaaggaaagtc	11	11	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:87338522C>T	uc004aoa.1	+	9	1556	c.618C>T	c.(616-618)CTC>CTT	p.L206L	NTRK2_uc004anv.1_Silent_p.L206L|NTRK2_uc004any.1_Silent_p.L206L|NTRK2_uc004anz.1_Silent_p.L206L|NTRK2_uc011lsz.1_Silent_p.L206L|NTRK2_uc011lta.1_Silent_p.L206L|NTRK2_uc004aob.1_Silent_p.L206L|NTRK2_uc011ltb.1_Silent_p.L50L	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	206	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						CACCTAACCTCACTGTGGAGG	0.408										TSP Lung(25;0.17)			0	0	0	0.004482	0	7	73										T	87338522	C	T	87338522	2	4	110	1	0	0	0	0	0	0	0	1	10707	813	29	1		1	NTRK2	9	87338522	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1333977	87338522	53874909	217	33729										
TMEFF1	8577	broad.mit.edu	37	chr9	103312381	103312381	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccgtcttctcttacagatacAgatgacactagtttgttggg	9	9	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:103312381A>T	uc004baz.1	+	7	824	c.714A>T	c.(712-714)ACA>ACT	p.T238T	TMEFF1_uc004bay.1_Silent_p.T312T	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	238	Extracellular (Potential).				multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				TTACAGATACAGATGACACTA	0.343													0	0	0	0.001168	0	6	75										T	103312381	A	T	103312381	2	4	110	1	0	0	0	0	0	0	0	1	16010	175	7	5		5	TMEFF1	9	103312381	Silent	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	15973859	103312381	37901050	218	33730										
SMC2	10592	broad.mit.edu	37	chr9	106894344	106894344	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaaatgacaaatccaaaattCttacaactatagaagacctt	3	8	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:106894344C>T	uc004bbv.2	+	22	3334	c.3046C>T	c.(3046-3048)CTT>TTT	p.L1016F	SMC2_uc004bbw.2_Missense_Mutation_p.L1016F|SMC2_uc011lvl.1_Missense_Mutation_p.L1016F|SMC2_uc004bbx.2_Missense_Mutation_p.L1016F|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1016	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						ATCCAAAATTCTTACAACTAT	0.308													0	0	0	0.009096	0	4	34										T	106894344	C	T	106894344	3	4	110	1	0	0	0	0	1	0	0	0	14783	913	32	1	3128	1	SMC2	9	106894344	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3581963	106894344	34319087	219	33731										
GAPVD1	26130	broad.mit.edu	37	chr9	128088742	128088742	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agctaaggaagtttgaaattCgtgacatgatgggattaaca	11	4	0	3	rs144122272	by1000genomes	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:128088742C>T	uc010mwx.2	+	12	2232	c.1906C>T	c.(1906-1908)CGT>TGT	p.R636C	GAPVD1_uc011lzs.1_Missense_Mutation_p.R636C|GAPVD1_uc004bpp.2_Missense_Mutation_p.R636C|GAPVD1_uc004bpq.2_Missense_Mutation_p.R636C|GAPVD1_uc004bpr.2_Missense_Mutation_p.R615C|GAPVD1_uc004bps.2_Missense_Mutation_p.R636C|GAPVD1_uc010mwy.1_Missense_Mutation_p.R495C	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	636					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GTTTGAAATTCGTGACATGAT	0.368													0	0	0	0.001168	0	5	89										T	128088742	C	T	128088742	3	4	110	1	0	0	0	0	1	0	0	0	6239	884	31	1	1940	1	GAPVD1	9	128088742	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	21194398	128088742	13124689	220	33732										
DOLPP1	57171	broad.mit.edu	37	chr9	131843433	131843433	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggcagcggacggacagtgctCgctccccgcttcatggcggc	15	15	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:131843433C>G	uc004bxc.2	+	1	51	c.23C>G	c.(22-24)TCG>TGG	p.S8W	DOLPP1_uc004bxd.2_Missense_Mutation_p.S8W|DOLPP1_uc004bxe.2_RNA	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	8					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						GGACAGTGCTCGCTCCCCGCT	0.672													0	0	0	0.00499	0	11	91										G	131843433	C	G	131843433	3	3	110	1	0	0	0	0	1	0	0	0	4704	893	31	1	25	1	DOLPP1	9	131843433	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3754691	131843433	9369998	221	33733										
ABL1	25	broad.mit.edu	37	chr9	133759972	133759972	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagccggctctgcctcggaaGagggcaggggagaacaggtc	17	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:133759972G>A	uc004bzw.2	+	11	2298	c.2295G>A	c.(2293-2295)AAG>AAA	p.K765K	ABL1_uc004bzv.2_Silent_p.K784K	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	765	Nuclear localization signal 3 (Potential).				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	TGCCTCGGAAGAGGGCAGGGG	0.582			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.00308	0	5	60										A	133759972	G	A	133759972	2	1	110	1	0	0	0	0	0	0	0	1	92	933	33	1		1	ABL1	9	133759972	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1916539	133759972	7453459	222	33734										
BAT2L1	84726	broad.mit.edu	37	chr9	134351676	134351676	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagcgacttcagcgagcggcGggagcggcgggaaggccctg	19	12	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr9:134351676G>A	uc004can.3	+	15	4215	c.4160G>A	c.(4159-4161)CGG>CAG	p.R1387Q	BAT2L1_uc010mzj.1_Missense_Mutation_p.R970Q|BAT2L1_uc004cao.3_Missense_Mutation_p.R745Q	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1387							protein binding				0						AGCGAGCGGCGGGAGCGGCGG	0.667											OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	2	2										A	134351676	G	A	134351676	3	1	110	1	0	0	0	0	1	0	0	0	1320	1116	39	2	4218	2	BAT2L1	9	134351676	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	591704	134351676	6861755	223	33735										
GDI2	2665	broad.mit.edu	37	chr10	5808246	5808246	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttggtaccaggaggtcactGatgctaacaaatctggaggg	13	7	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:5808246G>A	uc001iil.3	-	10	1440	c.1149C>T	c.(1147-1149)ATC>ATT	p.I383I	GDI2_uc001iim.3_Silent_p.I338I|GDI2_uc009xid.2_Silent_p.I387I	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	383					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						GGAGGTCACTGATGCTAACAA	0.502													0	0	0	0.001168	0	5	93										A	5808246	G	A	5808246	2	1	110	1	0	0	0	0	0	0	0	1	6321	1280	45	1		1	GDI2	10	5808246	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		5808246	129726501	224	33736										
UPF2	26019	broad.mit.edu	37	chr10	11994119	11994119	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tacctgcctgatggattcttCcagagaattacagagtttga	9	8	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:11994119C>T	uc001ila.2	-	14	3454	c.2980G>A	c.(2980-2982)GAA>AAA	p.E994K	UPF2_uc001ilb.2_Missense_Mutation_p.E994K|UPF2_uc001ilc.2_Missense_Mutation_p.E994K|UPF2_uc009xiz.1_Missense_Mutation_p.E994K	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	994	Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				ATGGATTCTTCCAGAGAATTA	0.368													0	0	0	0.005443	0	20	198										T	11994119	C	T	11994119	3	4	110	1	0	0	0	0	1	0	0	0	17001	864	30	1	870	1	UPF2	10	11994119	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6185873	11994119	123540628	225	33737										
MCM10	55388	broad.mit.edu	37	chr10	13225054	13225055	+	Missense_Mutation	DNP	GG	GG	AA													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggagcaggggactgtcgtagGgatcctcaatgccaacccca							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:13225054_13225055GG>AA	uc001ima.2	+	8	1156_1157	c.1055_1056GG>AA	c.(1054-1056)GGG>GAA	p.G352E	MCM10_uc001imb.2_Missense_Mutation_p.G351E|MCM10_uc001imc.2_Missense_Mutation_p.G351E	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	352					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						ACTGTCGTAGGGATCCTCAATG	0.46													0	0	0	0.004672	0	14	122										AA	13225055	GG	AA	13225054	3	1	110	1	0	0	0	0	1	0	0	0	9385	1232	43	2	1081	2	MCM10	10	13225054	Missense_Mutation	DNP	GG	TCGA-GD-A3OP-01A-21D-A21Z-08	1230935	13225054	122309693	226	33738										
C10orf111	221060	broad.mit.edu	37	chr10	15138479	15138479	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcggggagaaggaggaggctCattaggtcagaagcaacctg	17	7	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:15138479C>G	uc001inw.2	-	2	619	c.345G>C	c.(343-345)ATG>ATC	p.M115I	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	115	Helical; (Potential).					integral to membrane					0						GGAGGAGGCTCATTAGGTCAG	0.488													0	0	0	0.000602	0	4	65										G	15138479	C	G	15138479	3	3	110	1	0	0	0	0	1	0	0	0	1583	826	29	1	126	1	C10orf111	10	15138479	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1913425	15138479	120396268	227	33739										
PIP4K2A	5305	broad.mit.edu	37	chr10	22830755	22830755	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcatggcacttaattccataGacgtcgatgttcggatcgaa	9	9	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:22830755G>C	uc001irl.3	-	8	1262	c.1014C>G	c.(1012-1014)GTC>GTG	p.V338V	PIP4K2A_uc010qcu.1_Silent_p.V198V	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	338	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						TAATTCCATAGACGTCGATGT	0.517													0	0	0	0.004482	0	6	88										C	22830755	G	C	22830755	2	2	110	1	0	0	0	0	0	0	0	1	11936	929	33	1		1	PIP4K2A	10	22830755	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7692276	22830755	112703992	228	33740										
GPR158	57512	broad.mit.edu	37	chr10	25464659	25464659	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccaactgctccggccgctacGagttggcgggcctgccgggg	16	15	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:25464659G>C	uc001isj.2	+	1	370	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	LOC100128811_uc010qde.1_Missense_Mutation_p.S98W	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	104	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CGGCCGCTACGAGTTGGCGGG	0.677													0	0	0	0.004482	0	5	81										C	25464659	G	C	25464659	3	2	110	1	0	0	0	0	1	0	0	0	6663	1059	37	1	312	1	GPR158	10	25464659	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2633904	25464659	110070088	229	33741										
APBB1IP	54518	broad.mit.edu	37	chr10	26800720	26800720	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gataacagcacaaagtcactGatggtggatgagcggcagct	13	8	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:26800720G>A	uc001iss.2	+	7	897	c.576G>A	c.(574-576)CTG>CTA	p.L192L	APBB1IP_uc009xks.1_Silent_p.L192L	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	192	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CAAAGTCACTGATGGTGGATG	0.473													0	0	0	0.00308	0	6	127										A	26800720	G	A	26800720	2	1	110	1	0	0	0	0	0	0	0	1	760	1277	45	1		1	APBB1IP	10	26800720	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1336061	26800720	108734027	230	33742										
YME1L1	10730	broad.mit.edu	37	chr10	27423784	27423784	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggttttttgtgtgagtgcttGagctttcagaaaaccttccg	11	7	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:27423784G>A	uc001iti.2	-	7	1020	c.838C>T	c.(838-840)CAA>TAA	p.Q280*	YME1L1_uc001itj.2_Nonsense_Mutation_p.Q223*|YME1L1_uc010qdl.1_Nonsense_Mutation_p.Q190*|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	280					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						GTGAGTGCTTGAGCTTTCAGA	0.368													0	0	0	0.00308	0	6	92										A	27423784	G	A	27423784	4	1	110	1	0	0	0	0	0	1	0	0	17484	1299	45	1	1539	1	YME1L1	10	27423784	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	623064	27423784	108110963	231	33743										
CUL2	8453	broad.mit.edu	37	chr10	35317752	35317752	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acttaccatctgtacactttTttctaattcctggggaattg	6	9	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:35317752T>A	uc001ixv.2	-	16	1813	c.1603A>T	c.(1603-1605)AAA>TAA	p.K535*	CUL2_uc009xma.2_Nonsense_Mutation_p.K404*|CUL2_uc010qer.1_Nonsense_Mutation_p.K554*|CUL2_uc001ixw.2_Nonsense_Mutation_p.K535*|CUL2_uc010qes.1_Nonsense_Mutation_p.K472*	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	535					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						TGTACACTTTTTTCTAATTCC	0.323													0	0	0	0.004672	0	3	39										A	35317752	T	A	35317752	4	1	110	1	0	0	0	0	0	1	0	0	4055	1850	64	5	658	5	CUL2	10	35317752	Nonsense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	7893968	35317752	100216995	232	33744										
BMS1	9790	broad.mit.edu	37	chr10	43293936	43293936	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgacagaagataatgaagaaGaagatgatgatactctagaa	10	3	1	10			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:43293936G>C	uc001jaj.2	+	12	2468	c.2110G>C	c.(2110-2112)GAA>CAA	p.E704Q		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	704					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TAATGAAGAAGAAGATGATGA	0.438													0	0	0	0.004482	0	7	75										C	43293936	G	C	43293936	3	2	110	1	0	0	0	0	1	0	0	0	1472	943	33	1	2152	1	BMS1	10	43293936	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7976184	43293936	92240811	233	33745										
VDAC2	7417	broad.mit.edu	37	chr10	76982062	76982062	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atcagaaagtttgtgaagatCttgacacttcagtaaacctt	7	7	3	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:76982062C>T	uc001jwz.2	+	8	796	c.637C>T	c.(637-639)CTT>TTT	p.L213F	VDAC2_uc010qld.1_Missense_Mutation_p.L174F|VDAC2_uc001jxa.2_Missense_Mutation_p.L228F|VDAC2_uc010qle.1_Missense_Mutation_p.L174F	NM_003375	NP_003366	P45880	VDAC2_HUMAN	voltage-dependent anion channel 2	213	Beta stranded; (By similarity).					mitochondrial nucleoid|mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)				Dihydroxyaluminium(DB01375)	TTGTGAAGATCTTGACACTTC	0.358													0	0	0	0.000978	0	9	97										T	76982062	C	T	76982062	3	4	110	1	0	0	0	0	1	0	0	0	17144	913	32	1	743	1	VDAC2	10	76982062	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	33688126	76982062	58552685	234	33746										
ATRNL1	26033	broad.mit.edu	37	chr10	117040926	117040926	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gatttgtaacaaacttaccaGctgtaaaagctgttcactaa	6	8	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:117040926G>T	uc001lcg.2	+	14	2548	c.2162G>T	c.(2161-2163)AGC>ATC	p.S721I		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	721	PSI 3.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAACTTACCAGCTGTAAAAGC	0.353													1	0	2.31682e-05	0.003163	2.44935e-05	11	66										T	117040926	G	T	117040926	3	4	110	1	0	0	0	0	1	0	0	0	1207	971	34	4	2216	4	ATRNL1	10	117040926	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	40058864	117040926	18493821	235	33747										
EBF3	253738	broad.mit.edu	37	chr10	131671831	131671831	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacacggccagcacgtggccGtccacgttgactgttgtcga	13	13	0	1	rs147554322		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr10:131671831G>A	uc001lki.1	-	8	725	c.666C>T	c.(664-666)GAC>GAT	p.D222D		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	222					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GCACGTGGCCGTCCACGTTGA	0.522													0	0	0	0.004672	0	3	48										A	131671831	G	A	131671831	2	1	110	1	0	0	0	0	0	0	0	1	4882	1136	40	2		2	EBF3	10	131671831	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	14630905	131671831	3862916	236	33748										
MUC5B	727897	broad.mit.edu	37	chr11	1154305	1154305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctatcgcccgggggcccagcGgtgagtctgagtgtccggcc	16	14	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:1154305G>A	uc009ycr.1	+	3	277	c.151G>A	c.(151-153)GGG>AGG	p.G51R		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGGCCCAGCGGTGAGTCTGA	0.667													0	0	0	0.00308	0	6	26										A	1154305	G	A	1154305	3	1	110	1	0	0	0	0	1	0	0	0	9979	1131	39	2		2	MUC5B	11	1154305	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		1154305	133852211	237	33749										
MUC5B	727897	broad.mit.edu	37	chr11	1263825	1263825	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcaactccggggacgacctgGatcctcacaaagccgaccac	9	16	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:1263825G>C	uc009ycr.1	+	47	7920	c.7794G>C	c.(7792-7794)TGG>TGC	p.W2598C	MUC5B_uc001ltb.2_Missense_Mutation_p.W1908C	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1905	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGACGACCTGGATCCTCACAA	0.637													0	0	0	0.006122	0	14	209										C	1263825	G	C	1263825	3	2	110	1	0	0	0	0	1	0	0	0	9979	1183	41	1	5846	1	MUC5B	11	1263825	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	109520	1263825	133742691	238	33750										
KCNQ1	3784	broad.mit.edu	37	chr11	2610039	2610039	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcacgtgcgaccccccagaaGagcggcggctggaccacttc	12	16	1	2	rs148266527		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:2610039G>C	uc001lwn.2	+	10	1456	c.1348G>C	c.(1348-1350)GAG>CAG	p.E450Q	KCNQ1_uc009ydp.1_Missense_Mutation_p.E234Q|KCNQ1_uc001lwo.2_Missense_Mutation_p.E323Q	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	450	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CCCCCCAGAAGAGCGGCGGCT	0.562													0	0	0	0.000602	0	4	15										C	2610039	G	C	2610039	3	2	110	1	0	0	0	0	1	0	0	0	8082	943	33	1	1395	1	KCNQ1	11	2610039	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1346214	2610039	132396477	239	33751										
OR56A4	120793	broad.mit.edu	37	chr11	6023979	6023979	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaagatggccaggaccttggGgatgacggtgaggcagagca	18	7	0	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:6023979G>C	uc010qzv.1	-	1	400	c.400C>G	c.(400-402)CCC>GCC	p.P134A		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGACCTTGGGGATGACGGTG	0.567													0	0	0	0.001855	0	11	94										C	6023979	G	C	6023979	3	2	110	1	0	0	0	0	1	0	0	0	11135	1232	43	4	699	4	OR56A4	11	6023979	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3413940	6023979	128982537	240	33752										
OR10A6	390093	broad.mit.edu	37	chr11	7950137	7950137	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaagccacaaagagctgccCctggagctcaggatagttag	12	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:7950137C>G	uc010rbh.1	-	1	73	c.73G>C	c.(73-75)GGG>CGG	p.G25R		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAGAGCTGCCCCTGGAGCTCA	0.438													0	0	0	0.009096	0	4	89										G	7950137	C	G	7950137	3	3	110	1	0	0	0	0	1	0	0	0	10894	623	22	4	874	4	OR10A6	11	7950137	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1926158	7950137	127056379	241	33753										
SBF2	81846	broad.mit.edu	37	chr11	9851008	9851008	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttgcaagtatttctcttgttCtatgctactggaagattcta	7	7	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:9851008C>T	uc001mib.2	-	28	3826	c.3688G>A	c.(3688-3690)GAA>AAA	p.E1230K		NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1230	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TTCTCTTGTTCTATGCTACTG	0.368													0	0	0	0.001984	0	5	93										T	9851008	C	T	9851008	3	4	110	1	0	0	0	0	1	0	0	0	13859	922	32	1	1913	1	SBF2	11	9851008	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1900871	9851008	125155508	242	33754										
NAV2	89797	broad.mit.edu	37	chr11	20113769	20113769	+	Silent	SNP	G	G	T													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagagtgaaatagagaagctGaaagctgagaatgatcggct							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:20113769G>T	uc001mpr.3	+	28	6040	c.5679G>T	c.(5677-5679)CTG>CTT	p.L1893L	NAV2_uc001mpp.2_Silent_p.L1826L|NAV2_uc009yhx.2_Silent_p.L954L|NAV2_uc009yhz.2_Silent_p.L535L|NAV2_uc001mpu.2_Silent_p.L328L	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	1949	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TAGAGAAGCTGAAAGCTGAGA	0.498													1	0	0.00198382	0.001984	0.0020327	6	91										T	20113769	G	T	20113769	2	4	110	1	0	0	0	0	0	0	0	1	10184	1277	45	3		3	NAV2	11	20113769	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	10262761	20113769	114892747	243	33755	172	2								
NAV2	89797	broad.mit.edu	37	chr11	20113776	20113776	+	Missense_Mutation	SNP	G	G	A													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaatagagaagctgaaagctGagaatgatcggctgaagtca							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:20113776G>A	uc001mpr.3	+	28	6047	c.5686G>A	c.(5686-5688)GAG>AAG	p.E1896K	NAV2_uc001mpp.2_Missense_Mutation_p.E1829K|NAV2_uc009yhx.2_Missense_Mutation_p.E957K|NAV2_uc009yhz.2_Missense_Mutation_p.E538K|NAV2_uc001mpu.2_Missense_Mutation_p.E331K	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	1952	Potential.					nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						GCTGAAAGCTGAGAATGATCG	0.507													0	0	0	0.00308	0	6	97										A	20113776	G	A	20113776	3	1	110	1	0	0	0	0	1	0	0	0	10184	1291	45	1	5905	1	NAV2	11	20113776	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7	20113776	114892740	244	33756	172	2								
DCDC1	341019	broad.mit.edu	37	chr11	31329201	31329201	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	attacctcagttgacccactGgagcactgacaggtctgttt	9	11	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:31329201G>A	uc001msv.2	-	4	621	c.419C>T	c.(418-420)CCA>CTA	p.P140L	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	140					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TTGACCCACTGGAGCACTGAC	0.358													0	0	0	0.003163	0	12	95										A	31329201	G	A	31329201	3	1	110	1	0	0	0	0	1	0	0	0	4284	1348	47	2	669	2	DCDC1	11	31329201	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	11215425	31329201	103677315	245	33757										
COMMD9	29099	broad.mit.edu	37	chr11	36297736	36297736	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccatgcggctgatgctgtctGaggaggttttgatatccact	12	9	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:36297736G>A	uc001mwn.3	-	5	444	c.407C>T	c.(406-408)TCA>TTA	p.S136L	COMMD9_uc009ykj.2_Missense_Mutation_p.S94L|COMMD9_uc009yki.1_5'Flank	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	136	COMM.									ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				GATGCTGTCTGAGGAGGTTTT	0.552													0	0	0	0.001168	0	5	92										A	36297736	G	A	36297736	3	1	110	1	0	0	0	0	1	0	0	0	3723	1294	45	1	197	1	COMMD9	11	36297736	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4968535	36297736	98708780	246	33758										
TSPAN18	90139	broad.mit.edu	37	chr11	44948255	44948255	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cggtgatcctcaacaccttcGagacctacgtctacttggcc	8	15	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:44948255G>A	uc001mye.3	+	7	807	c.646G>A	c.(646-648)GAG>AAG	p.E216K	TP53I11_uc001myf.1_Intron|TSPAN18_uc001myg.2_Missense_Mutation_p.E216K	NM_130783	NP_570139	Q96SJ8	TSN18_HUMAN	tetraspanin 18 isoform 2	216	Extracellular (Potential).					integral to membrane					0						CAACACCTTCGAGACCTACGT	0.592											OREG0020922	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	19	252										A	44948255	G	A	44948255	3	1	110	1	0	0	0	0	1	0	0	0	16639	1059	37	1	668	1	TSPAN18	11	44948255	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	8650519	44948255	90058261	247	33759										
OR5T3	390154	broad.mit.edu	37	chr11	56020432	56020432	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttcctgtgatttcattctgTtgtccattctgaagatgcat	7	8	3	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:56020432T>C	uc010rjd.1	+	1	757	c.757T>C	c.(757-759)TTG>CTG	p.L253L		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	253	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TTTCATTCTGTTGTCCATTCT	0.413													0	0	0	0.004007	0	14	184										C	56020432	T	C	56020432	2	2	110	1	0	0	0	0	0	0	0	1	11183	1722	60	5		5	OR5T3	11	56020432	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	11072177	56020432	78986084	248	33760										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57076793	57076793	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taaagccagcaccactcactCtgtcgttgccaatgatgcca	7	14	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:57076793C>G	uc001njr.2	-	5	3704	c.3392G>C	c.(3391-3393)AGA>ACA	p.R1131T	TNKS1BP1_uc001njs.2_Missense_Mutation_p.R1131T|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.R582T	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1131	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				ACCACTCACTCTGTCGTTGCC	0.577													0	0	0	0.00499	0	13	144										G	57076793	C	G	57076793	3	3	110	1	0	0	0	0	1	0	0	0	16317	913	32	1	1821	1	TNKS1BP1	11	57076793	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1056361	57076793	77929723	249	33761										
SLC43A1	8501	broad.mit.edu	37	chr11	57259332	57259332	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggctcttgcgtaaggggacaGaccctggggagacagcaggg	18	9	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:57259332G>A	uc001nkk.2	-	9	993	c.875C>T	c.(874-876)TCT>TTT	p.S292F	SLC43A1_uc001nkl.2_Missense_Mutation_p.S292F	NM_003627	NP_003618	O75387	LAT3_HUMAN	solute carrier family 43, member 1	292					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity				0						TAAGGGGACAGACCCTGGGGA	0.607											OREG0020651	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	37										A	57259332	G	A	57259332	3	1	110	1	0	0	0	0	1	0	0	0	14632	942	33	1	832	1	SLC43A1	11	57259332	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	182539	57259332	77747184	250	33762										
OR6Q1	219952	broad.mit.edu	37	chr11	57799186	57799186	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacctgactgtggtgagcctCttctatggcactcttttctt	8	12	4	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:57799186C>T	uc010rjz.1	+	1	762	c.762C>T	c.(760-762)CTC>CTT	p.L254L	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				TGGTGAGCCTCTTCTATGGCA	0.522													0	0	0	0.00333	0	18	128										T	57799186	C	T	57799186	2	4	110	1	0	0	0	0	0	0	0	1	11208	900	32	1		1	OR6Q1	11	57799186	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	539854	57799186	77207330	251	33763										
FAM111B	374393	broad.mit.edu	37	chr11	58893123	58893123	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgtgcgaaggtaaccttcaCttatacagagttctgcccta	8	10	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:58893123C>G	uc001nnl.2	+	4	1796	c.1553C>G	c.(1552-1554)ACT>AGT	p.T518S	FAM111B_uc001nnm.2_Missense_Mutation_p.T488S|FAM111B_uc010rko.1_Missense_Mutation_p.T488S	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	518							catalytic activity			ovary(2)	2						GTAACCTTCACTTATACAGAG	0.373													0	0	0	0.004007	0	13	147										G	58893123	C	G	58893123	3	3	110	1	0	0	0	0	1	0	0	0	5400	565	20	4	1559	4	FAM111B	11	58893123	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1093937	58893123	76113393	252	33764										
CDC42BPG	55561	broad.mit.edu	37	chr11	64595223	64595223	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaacacatcgatggagttctCgctgaacactgtcaggtagg	11	9	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:64595223C>T	uc001obs.3	-	31	4000	c.4000G>A	c.(4000-4002)GAG>AAG	p.E1334K		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1334	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						ATGGAGTTCTCGCTGAACACT	0.637													0	0	0	0.004482	0	7	84										T	64595223	C	T	64595223	3	4	110	1	0	0	0	0	1	0	0	0	3074	893	31	1	683	1	CDC42BPG	11	64595223	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5702100	64595223	70411293	253	33765										
LTBP3	4054	broad.mit.edu	37	chr11	65318916	65318916	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtggtggcagttgggtggctCtgctgcactgacctctcctc	14	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:65318916C>T	uc001oej.2	-	10	1847	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	LTBP3_uc001oeh.2_5'Flank|LTBP3_uc010roi.1_Silent_p.Q409Q|LTBP3_uc001oei.2_Silent_p.Q526Q|LTBP3_uc010roj.1_Silent_p.Q227Q|LTBP3_uc010rok.1_Silent_p.Q437Q	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	526						extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						TTGGGTGGCTCTGCTGCACTG	0.652													0	0	0	0.001168	0	5	55										T	65318916	C	T	65318916	2	4	110	1	0	0	0	0	0	0	0	1	9075	912	32	1		1	LTBP3	11	65318916	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	723693	65318916	69687600	254	33766										
TMEM151A	256472	broad.mit.edu	37	chr11	66063113	66063113	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gctgccagggggatgggcagGgtgctctctgagacccccca	16	13	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:66063113G>A	uc001ohl.2	+	2	1508	c.1396G>A	c.(1396-1398)GGT>AGT	p.G466S		NM_153266	NP_694998	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	466						integral to membrane				central_nervous_system(1)	1						GGATGGGCAGGGTGCTCTCTG	0.652													0	0	0	0.001984	0	5	27										A	66063113	G	A	66063113	3	1	110	1	0	0	0	0	1	0	0	0	16067	1232	43	2	1402	2	TMEM151A	11	66063113	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	744197	66063113	68943403	255	33767										
ZDHHC24	254359	broad.mit.edu	37	chr11	66313210	66313210	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcacgcccagccctggcccaGaccgcggccggccagcatca	11	20	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:66313210G>A	uc001oin.1	-	1	462	c.265C>T	c.(265-267)CTG>TTG	p.L89L	ACTN3_uc010rpi.1_5'Flank|ACTN3_uc001oio.1_5'Flank|ZDHHC24_uc001oim.1_RNA|ZDHHC24_uc009yrg.1_Silent_p.L89L	NM_207340	NP_997223	Q6UX98	ZDH24_HUMAN	zinc finger, DHHC-type containing 24	89						integral to membrane	acyltransferase activity|zinc ion binding				0						CCCTGGCCCAGACCGCGGCCG	0.701													0	0	0	0.004672	0	3	14										A	66313210	G	A	66313210	2	1	110	1	0	0	0	0	0	0	0	1	17612	933	33	1		1	ZDHHC24	11	66313210	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	250097	66313210	68693306	256	33768										
RNF169	254225	broad.mit.edu	37	chr11	74545750	74545750	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctccaaggtggaaaggagtcAgagctgtagtgacacagccc	13	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:74545750A>G	uc001ovl.3	+	5	885	c.872A>G	c.(871-873)CAG>CGG	p.Q291R	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	291							zinc ion binding			ovary(1)	1						GAAAGGAGTCAGAGCTGTAGT	0.443													0	0	0	0.009096	0	4	58										G	74545750	A	G	74545750	3	3	110	1	0	0	0	0	1	0	0	0	13460	188	7	5	890	5	RNF169	11	74545750	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	8232540	74545750	60460766	257	33769										
SLCO2B1	11309	broad.mit.edu	37	chr11	74873787	74873787	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acctggaggcaaagccagccCagaccctcaggacgtgcggc	13	15	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:74873787C>T	uc001owb.2	+	2	491	c.104C>T	c.(103-105)CCA>CTA	p.P35L	SLCO2B1_uc010rrp.1_RNA|SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Intron|SLCO2B1_uc010rrs.1_Intron|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Missense_Mutation_p.P13L	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	35	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	AAAGCCAGCCCAGACCCTCAG	0.547													0	0	0	0.001368	0	12	147										T	74873787	C	T	74873787	3	4	110	1	0	0	0	0	1	0	0	0	14727	594	21	2	110	2	SLCO2B1	11	74873787	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	328037	74873787	60132729	258	33770										
CCDC83	220047	broad.mit.edu	37	chr11	85627263	85627265	+	In_Frame_Del	DEL	AGA	AGA	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtacttactatatgaggatgAgaaggatttcaaggtaagat							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:85627263_85627265delAGA	uc001pbh.1	+	10	1579_1581	c.1067_1069delAGA	c.(1066-1071)GAGAAG>GAG	p.K357del	CCDC83_uc001pbg.1_In_Frame_Del_p.K388del|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_In_Frame_Del_p.K257del	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	357										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TATGAGGATGAGAAGGATTTCAA	0.335																		12	127	---	---								-	85627265	AGA	-	85627263	7	5	110	1	0	1	0	1	0	0	0	0	2857	304	11	0	1198	0	CCDC83	11	85627263	In_Frame_Del	DEL	AGA	TCGA-GD-A3OP-01A-21D-A21Z-08	10753476	85627263	49379253	259	33771										
NCAM1	4684	broad.mit.edu	37	chr11	113130955	113130955	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggactggaatgctgagtatGaggtctacgtggtggctgag	17	5	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:113130955G>A	uc001pns.2	+	2	213	c.181G>A	c.(181-183)GAG>AAG	p.E61K				P13591	NCAM1_HUMAN	SubName: Full=cDNA FLJ52974, highly similar to Neural cell adhesion molecule 1, 140 kDa isoform;	681	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TGCTGAGTATGAGGTCTACGT	0.567													0	0	0	0.006214	0	8	88										A	113130955	G	A	113130955	3	1	110	1	0	0	0	0	1	0	0	0	10202	1291	45	1	2221	1	NCAM1	11	113130955	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	27503692	113130955	21875561	260	33772										
USP2	9099	broad.mit.edu	37	chr11	119244114	119244114	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acggggtgtaggcaccatagCccgacttggcatagtgggca	15	10	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:119244114C>T	uc001pwm.3	-	2	372	c.77G>A	c.(76-78)GGC>GAC	p.G26D	USP2_uc001pwn.3_Intron	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	26	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		GGCACCATAGCCCGACTTGGC	0.597													0	0	0	0.001168	0	5	35										T	119244114	C	T	119244114	3	4	110	1	0	0	0	0	1	0	0	0	17048	739	26	2	1939	2	USP2	11	119244114	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6113159	119244114	15762402	261	33773										
ARHGEF12	23365	broad.mit.edu	37	chr11	120312861	120312861	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aacataccaattccaaagaaActcgtcgcatcttccttgag	5	12	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:120312861A>G	uc001pxl.1	+	15	1259	c.1252A>G	c.(1252-1254)ACT>GCT	p.T418A	ARHGEF12_uc009zat.2_Missense_Mutation_p.T399A|ARHGEF12_uc010rzn.1_Missense_Mutation_p.T315A|ARHGEF12_uc009zau.1_Missense_Mutation_p.T315A	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	418	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TTCCAAAGAAACTCGTCGCAT	0.358			T	MLL	AML								0	0	0	0.009096	0	4	50										G	120312861	A	G	120312861	3	3	110	1	0	0	0	0	1	0	0	0	897	43	2	5	1310	5	ARHGEF12	11	120312861	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	1068747	120312861	14693655	262	33774										
SORL1	6653	broad.mit.edu	37	chr11	121414362	121414362	+	Silent	SNP	C	C	T													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggggagaagagcactgtcttCaccatctttggctcgaacaa							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:121414362C>T	uc001pxx.2	+	13	1871	c.1791C>T	c.(1789-1791)TTC>TTT	p.F597F		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	597	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GCACTGTCTTCACCATCTTTG	0.512													0	0	0	0.006214	0	7	185										T	121414362	C	T	121414362	2	4	110	1	0	0	0	0	0	0	0	1	14934	825	29	1		1	SORL1	11	121414362	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1101501	121414362	13592154	263	33775	173	2								
SORL1	6653	broad.mit.edu	37	chr11	121414368	121414368	+	Missense_Mutation	SNP	C	C	G													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagagcactgtcttcaccatCtttggctcgaacaaagagaa							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr11:121414368C>G	uc001pxx.2	+	13	1877	c.1797C>G	c.(1795-1797)ATC>ATG	p.I599M		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	599	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCTTCACCATCTTTGGCTCGA	0.512													0	0	0	0.00308	0	7	181										G	121414368	C	G	121414368	3	3	110	1	0	0	0	0	1	0	0	0	14934	903	32	1	1847	1	SORL1	11	121414368	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6	121414368	13592148	264	33776	173	2								
ADIPOR2	79602	broad.mit.edu	37	chr12	1895205	1895205	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caggagtttcgtttcatgatCggcgggggctgcagtgaaga	16	7	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:1895205C>T	uc001qjm.2	+	8	1325	c.1128C>T	c.(1126-1128)ATC>ATT	p.I376I	ADIPOR2_uc001qjn.2_Silent_p.I376I	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	376	Extracellular (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			GTTTCATGATCGGCGGGGGCT	0.532													0	0	0	0.001984	0	7	117										T	1895205	C	T	1895205	2	4	110	1	0	0	0	0	0	0	0	1	319	874	31	1		1	ADIPOR2	12	1895205	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		1895205	131956690	265	33777										
PRMT8	56341	broad.mit.edu	37	chr12	3692332	3692332	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccctggtcacctattttaatAttgaatttaccaagtgccac	5	11	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:3692332A>G	uc001qmf.2	+	8	1304	c.937A>G	c.(937-939)ATT>GTT	p.I313V	PRMT8_uc009zed.2_Missense_Mutation_p.I304V|PRMT8_uc009zee.1_RNA|PRMT8_uc001qmg.2_Missense_Mutation_p.I127V	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	313					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CTATTTTAATATTGAATTTAC	0.478													0	0	0	0.000602	0	4	20										G	3692332	A	G	3692332	3	3	110	1	0	0	0	0	1	0	0	0	12542	449	16	5	967	5	PRMT8	12	3692332	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	1797127	3692332	130159563	266	33778										
CLSTN3	9746	broad.mit.edu	37	chr12	7290563	7290563	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gccctcagaggacggcttctCtcactactcgctgactgtcc	9	16	3	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:7290563C>G	uc001qsr.2	+	8	1501	c.1223C>G	c.(1222-1224)TCT>TGT	p.S408C	CLSTN3_uc001qss.2_Missense_Mutation_p.S420C	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	408	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GACGGCTTCTCTCACTACTCG	0.577													0	0	0	0.006122	0	15	105										G	7290563	C	G	7290563	3	3	110	1	0	0	0	0	1	0	0	0	3563	913	32	1	1253	1	CLSTN3	12	7290563	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3598231	7290563	126561332	267	33779										
SLCO1B3	28234	broad.mit.edu	37	chr12	21036424	21036424	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	actcagcacacttgggtgaaTgcccaagagataatacttgt	9	9	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:21036424T>A	uc001rek.2	+	12	1696	c.1570T>A	c.(1570-1572)TGC>AGC	p.C524S	SLCO1B3_uc001rel.2_Missense_Mutation_p.C524S|SLCO1B3_uc010sil.1_Missense_Mutation_p.C524S|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.C349S	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	524	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CTTGGGTGAATGCCCAAGAGA	0.338													0	0	0	0.001984	0	5	79										A	21036424	T	A	21036424	3	1	110	1	0	0	0	0	1	0	0	0	14724	1464	51	5	1612	5	SLCO1B3	12	21036424	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	13745861	21036424	112815471	268	33780										
LRRK2	120892	broad.mit.edu	37	chr12	40631899	40631899	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagctttacatgtgctgtttGagagaggtattttaaaatgt	10	3	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:40631899G>A	uc001rmg.3	+	5	686	c.565G>A	c.(565-567)GAG>AAG	p.E189K		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	189					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGTGCTGTTTGAGAGAGGTAT	0.318													0	0	0	0.004482	0	8	59										A	40631899	G	A	40631899	3	1	110	1	0	0	0	0	1	0	0	0	9033	1291	45	1	583	1	LRRK2	12	40631899	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	19595475	40631899	93219996	269	33781										
ARID2	196528	broad.mit.edu	37	chr12	46230554	46230554	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggagaatggatttgggagtCtttatttcatccacctcgaa	10	7	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:46230554C>T	uc001ros.1	+	8	803	c.803C>T	c.(802-804)TCT>TTT	p.S268F	ARID2_uc001ror.2_Missense_Mutation_p.S268F|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	268					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATTTGGGAGTCTTTATTTCAT	0.348													0	0	0	0.00308	0	7	74										T	46230554	C	T	46230554	3	4	110	1	0	0	0	0	1	0	0	0	915	913	32	1	833	1	ARID2	12	46230554	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5598655	46230554	87621341	270	33782										
ARID2	196528	broad.mit.edu	37	chr12	46298835	46298835	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagttcagagtaaggaacaaGaaaaagactcagaaatgctg	10	6	2	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:46298835G>C	uc001ros.1	+	21	5482	c.5482G>C	c.(5482-5484)GAA>CAA	p.E1828Q	ARID2_uc009zkg.1_Missense_Mutation_p.E1284Q|ARID2_uc009zkh.1_Missense_Mutation_p.E1455Q|ARID2_uc001rou.1_3'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1828					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TAAGGAACAAGAAAAAGACTC	0.388													0	0	0	0.009096	0	3	34										C	46298835	G	C	46298835	3	2	110	1	0	0	0	0	1	0	0	0	915	943	33	1	5564	1	ARID2	12	46298835	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	68281	46298835	87553060	271	33783										
C12orf41	54934	broad.mit.edu	37	chr12	49054188	49054188	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaactctcagtgggctgaagCtcagcagcactcaagtacag	10	11	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:49054188C>T	uc001rrx.2	-	8	1263	c.1188G>A	c.(1186-1188)GAG>GAA	p.E396E	C12orf41_uc001rrw.2_Intron|C12orf41_uc001rrz.2_Silent_p.E579E|C12orf41_uc001rry.2_Intron|C12orf41_uc001rru.2_Silent_p.E27E|C12orf41_uc001rrv.2_Intron	NM_017822	NP_060292	Q9H9L4	CL041_HUMAN	hypothetical protein LOC54934	396										ovary(2)	2						TGGGCTGAAGCTCAGCAGCAC	0.493													0	0	0	0.001168	0	5	35										T	49054188	C	T	49054188	2	4	110	1	0	0	0	0	0	0	0	1	1687	796	28	2		2	C12orf41	12	49054188	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2755353	49054188	84797707	272	33784										
MLL2	8085	broad.mit.edu	37	chr12	49445757	49445757	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caggtggtggagacaggcgaGatgcttcaggtggcggggaa	20	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:49445757G>C	uc001rta.3	-	10	1709	c.1709C>G	c.(1708-1710)TCT>TGT	p.S570C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	570	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGACAGGCGAGATGCTTCAGG	0.592			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.001368	0	12	151										C	49445757	G	C	49445757	3	2	110	1	0	0	0	0	1	0	0	0	9621	942	33	1	15084	1	MLL2	12	49445757	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	391569	49445757	84406138	273	33785										
LARP4	113251	broad.mit.edu	37	chr12	50829320	50829320	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tatctcaaatggatagtgatCagttcatcccaatttggaca	7	8	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:50829320C>T	uc001rwp.1	+	5	592	c.448C>T	c.(448-450)CAG>TAG	p.Q150*	LARP4_uc001rwo.1_Nonsense_Mutation_p.Q156*|LARP4_uc001rwq.1_Nonsense_Mutation_p.Q150*|LARP4_uc001rwr.1_Nonsense_Mutation_p.Q150*|LARP4_uc001rws.1_Nonsense_Mutation_p.Q149*|LARP4_uc009zlr.1_5'Flank|LARP4_uc001rwm.2_Nonsense_Mutation_p.Q150*|LARP4_uc001rwn.2_Nonsense_Mutation_p.Q80*	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	150	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(1)	1						GGATAGTGATCAGTTCATCCC	0.299													0	0	0	0.00308	0	5	47										T	50829320	C	T	50829320	4	4	110	1	0	0	0	0	0	1	0	0	8630	827	29	1	466	1	LARP4	12	50829320	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1383563	50829320	83022575	274	33786										
TFCP2	7024	broad.mit.edu	37	chr12	51500367	51500367	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccaggtgatggggagttattGacatacgtgatctcgggcca	14	8	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:51500367G>A	uc001rxw.2	-	8	1317	c.858C>T	c.(856-858)GTC>GTT	p.V286V	TFCP2_uc001rxv.1_Silent_p.V286V|TFCP2_uc009zlx.1_Silent_p.V235V|TFCP2_uc001rxx.2_Silent_p.V286V|TFCP2_uc009zly.1_Silent_p.V188V	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	286	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGAGTTATTGACATACGTGA	0.398													0	0	0	0.001984	0	5	55										A	51500367	G	A	51500367	2	1	110	1	0	0	0	0	0	0	0	1	15792	1277	45	1		1	TFCP2	12	51500367	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	671047	51500367	82351528	275	33787										
KRT72	140807	broad.mit.edu	37	chr12	52984645	52984645	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcttcacattccctatctctGagcggatcctctggatcagg	8	13	5	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:52984645G>C	uc001sar.2	-	6	1150	c.1064C>G	c.(1063-1065)TCA>TGA	p.S355*	KRT72_uc001saq.2_Nonsense_Mutation_p.S355*|KRT72_uc010sns.1_Intron|KRT72_uc010snt.1_Nonsense_Mutation_p.S167*	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	355	Coil 2.|Rod.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		CCCTATCTCTGAGCGGATCCT	0.488													0	0	0	0.00245	0	12	98										C	52984645	G	C	52984645	4	2	110	1	0	0	0	0	0	1	0	0	8485	1294	45	1	487	1	KRT72	12	52984645	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1484278	52984645	80867250	276	33788										
RARG	5916	broad.mit.edu	37	chr12	53605514	53605514	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cccccaggaacctcatcctcGctagaggcattggggtgggg	14	13	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:53605514G>C	uc001sce.2	-	10	1796	c.1311C>G	c.(1309-1311)AGC>AGG	p.S437R	RARG_uc001scd.2_Missense_Mutation_p.S426R|RARG_uc010sob.1_Missense_Mutation_p.S415R|RARG_uc001scf.2_Missense_Mutation_p.S437R|RARG_uc001scg.2_Missense_Mutation_p.S365R|RARG_uc010soc.1_Missense_Mutation_p.S316R	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	437					canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CCTCATCCTCGCTAGAGGCAT	0.637													0	0	0	0.004672	0	3	23										C	53605514	G	C	53605514	3	2	110	1	0	0	0	0	1	0	0	0	13054	1078	38	4	57	4	RARG	12	53605514	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	620869	53605514	80246381	277	33789										
ATF7	11016	broad.mit.edu	37	chr12	53994749	53994749	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaacgtacctgtccacagccCggggcattgcacacaaacgg	10	14	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:53994749C>A	uc001sdy.2	-	1	57	c.36G>T	c.(34-36)CCG>CCT	p.P12P	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Silent_p.P12P|ATF7_uc010sol.1_Silent_p.P12P|ATF7_uc001sea.3_Silent_p.P12P|ATF7_uc001seb.3_Silent_p.P12P	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	12	C2H2-type.|Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GTCCACAGCCCGGGGCATTGC	0.433													1	0	0.00198382	0.001984	0.0020327	5	38										A	53994749	C	A	53994749	2	1	110	1	0	0	0	0	0	0	0	1	1086	639	23	4		4	ATF7	12	53994749	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	389235	53994749	79857146	278	33790										
ZBTB39	9880	broad.mit.edu	37	chr12	57398642	57398642	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tctgagagccggcacttgttGagttccttcagcaggttgtt	12	9	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:57398642G>C	uc001sml.1	-	2	146	c.60C>G	c.(58-60)CTC>CTG	p.L20L	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						GGCACTTGTTGAGTTCCTTCA	0.557													0	0	0	0.008291	0	9	206										C	57398642	G	C	57398642	2	2	110	1	0	0	0	0	0	0	0	1	17537	1277	45	1		1	ZBTB39	12	57398642	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3403893	57398642	76453253	279	33791										
NUP107	57122	broad.mit.edu	37	chr12	69121157	69121157	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtttctattgaagttttaaaGacatacatacaggtaaactt	6	5	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:69121157G>C	uc001suf.2	+	20	1837	c.1722G>C	c.(1720-1722)AAG>AAC	p.K574N	NUP107_uc001sug.2_Missense_Mutation_p.K421N|NUP107_uc010stj.1_Missense_Mutation_p.K545N	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	574					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AAGTTTTAAAGACATACATAC	0.269													0	0	0	0.000602	0	4	83										C	69121157	G	C	69121157	3	2	110	1	0	0	0	0	1	0	0	0	10753	933	33	1	1800	1	NUP107	12	69121157	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	11722515	69121157	64730738	280	33792										
LGR5	8549	broad.mit.edu	37	chr12	71960693	71960693	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttacctaatctccaagtgctGtgcgtatcagtaaggcaata	8	9	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:71960693G>A	uc001swl.2	+	11	1118	c.1070_splice	c.e11+1	p.L357_splice	LGR5_uc001swm.2_Splice_Site_p.L333_splice|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled							integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TCCAAGTGCTGTGCGTATCAG	0.393													0	0	0	0.001984	0	6	89										A	71960693	G	A	71960693	5	1	110	1	0	0	0	0	0	0	1	0	8757	1391	48	2	1113	2	LGR5	12	71960693	Splice_Site	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2839536	71960693	61891202	281	33793										
EEA1	8411	broad.mit.edu	37	chr12	93226360	93226360	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgttgttgtagctgcttaaaCtccgcctttagatgctggta	10	8	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:93226360C>G	uc001tck.2	-	11	1447	c.1182G>C	c.(1180-1182)GAG>GAC	p.E394D		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	394	Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						GCTGCTTAAACTCCGCCTTTA	0.358													0	0	0	0.000978	0	9	201										G	93226360	C	G	93226360	3	3	110	1	0	0	0	0	1	0	0	0	4921	564	20	4	3129	4	EEA1	12	93226360	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	21265667	93226360	40625535	282	33794										
FGD6	55785	broad.mit.edu	37	chr12	95566467	95566467	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgatgatttcctcctcatcaGagggaaggtcaccaagacca	9	11	3	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:95566467G>A	uc001tdp.3	-	3	2719	c.2495C>T	c.(2494-2496)TCT>TTT	p.S832F	FGD6_uc009zsx.2_5'UTR	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	832				S -> P (in Ref. 3; CAD98096).	actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CTCCTCATCAGAGGGAAGGTC	0.433													0	0	0	0.000978	0	10	163										A	95566467	G	A	95566467	3	1	110	1	0	0	0	0	1	0	0	0	5837	942	33	1	1873	1	FGD6	12	95566467	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2340107	95566467	38285428	283	33795										
NUAK1	9891	broad.mit.edu	37	chr12	106500216	106500216	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gatgatatgaggatggttgaGagatgacatgatctcaatct	12	4	2	6			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:106500216G>C	uc001tlj.1	-	2	1708	c.328C>G	c.(328-330)CTC>GTC	p.L110V		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	110	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						GGATGGTTGAGAGATGACATG	0.373													0	0	0	0.009096	0	3	33										C	106500216	G	C	106500216	3	2	110	1	0	0	0	0	1	0	0	0	10712	942	33	1	1681	1	NUAK1	12	106500216	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	10933749	106500216	27351679	284	33796										
IFT81	28981	broad.mit.edu	37	chr12	110641690	110641690	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aactgacccaggagtgtgatGaaaagaaatcccagtatgat	10	7	0	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr12:110641690G>C	uc001tqi.2	+	15	1709	c.1579G>C	c.(1579-1581)GAA>CAA	p.E527Q	IFT81_uc001tqh.2_Missense_Mutation_p.E527Q|IFT81_uc001tqj.2_RNA	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	527	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						ggagtgtgatgaaaagaaatc	0.194													0	0	0	0.004482	0	9	36										C	110641690	G	C	110641690	3	2	110	1	0	0	0	0	1	0	0	0	7565	1291	45	1	1745	1	IFT81	12	110641690	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4141474	110641690	23210205	285	33797										
XPO4	64328	broad.mit.edu	37	chr13	21442787	21442787	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttgatttcctaaatgataaGaatatgtgctctgcatgctg	8	6	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:21442787G>C	uc001unq.3	-	2	159	c.123C>G	c.(121-123)TTC>TTG	p.F41L	XPO4_uc010tcr.1_Intron	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	41					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TAAATGATAAGAATATGTGCT	0.338													0	0	0	0.004482	0	7	195										C	21442787	G	C	21442787	3	2	110	1	0	0	0	0	1	0	0	0	17443	933	33	1	3420	1	XPO4	13	21442787	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		21442787	93727091	286	33798										
PARP4	143	broad.mit.edu	37	chr13	25008866	25008866	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggcagcctaaggttggcagtCaaagaggctgcggaaggttg	17	7	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:25008866C>T	uc001upl.2	-	31	4519	c.4413G>A	c.(4411-4413)TTG>TTA	p.L1471L		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1471					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		GGTTGGCAGTCAAAGAGGCTG	0.493													0	0	0	0.004482	0	8	18										T	25008866	C	T	25008866	2	4	110	1	0	0	0	0	0	0	0	1	11463	825	29	1		1	PARP4	13	25008866	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3566079	25008866	90161012	287	33799										
RXFP2	122042	broad.mit.edu	37	chr13	32313816	32313816	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttacaatgttctttctacttCatttcatcgttctgatcaat	3	9	6	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:32313816C>T	uc001utt.2	+	1	138	c.67C>T	c.(67-69)CAT>TAT	p.H23Y	RXFP2_uc010aba.2_Missense_Mutation_p.H6Y	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	23	Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CTTTCTACTTCATTTCATCGT	0.333													0	0	0	0.001168	0	5	88										T	32313816	C	T	32313816	3	4	110	1	0	0	0	0	1	0	0	0	13760	826	29	1	69	1	RXFP2	13	32313816	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	7304950	32313816	82856062	288	33800										
LCP1	3936	broad.mit.edu	37	chr13	46708313	46708313	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcttccctcaatgtttcattCacccagttgacaataatgtc	5	12	3	1	rs111548644		TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:46708313C>T	uc001vaz.3	-	14	1701	c.1575G>A	c.(1573-1575)GTG>GTA	p.V525V	LCP1_uc010ack.2_Silent_p.V94V|LCP1_uc001vay.3_Silent_p.V122V|LCP1_uc001vba.3_Silent_p.V525V	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	525	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		ATGTTTCATTCACCCAGTTGA	0.393			T	BCL6	NHL 								0	0	0	0.001368	0	11	93										T	46708313	C	T	46708313	2	4	110	1	0	0	0	0	0	0	0	1	8691	813	29	1		1	LCP1	13	46708313	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	14394497	46708313	68461565	289	33801										
DACH1	1602	broad.mit.edu	37	chr13	72053440	72053440	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcattatctatggcaactttCaacagcccctgtacaaagaa	6	11	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:72053440C>T	uc010thn.1	-	9	2154	c.1731G>A	c.(1729-1731)TTG>TTA	p.L577L	DACH1_uc010tho.1_Silent_p.L429L|DACH1_uc010thp.1_Silent_p.L375L	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	629	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGGCAACTTTCAACAGCCCCT	0.358													0	0	0	0.006214	0	8	132										T	72053440	C	T	72053440	2	4	110	1	0	0	0	0	0	0	0	1	4220	825	29	1		1	DACH1	13	72053440	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	25345127	72053440	43116438	290	33802										
DZIP1	22873	broad.mit.edu	37	chr13	96274734	96274734	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttctggatttctgacagttGctataagataaaattcaagc	7	7	3	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:96274734G>A	uc001vmk.2	-	9	1825	c.973C>T	c.(973-975)CAA>TAA	p.Q325*	DZIP1_uc001vml.2_Nonsense_Mutation_p.Q325*	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	325	Potential.				germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TCTGACAGTTGCTATAAGATA	0.373													0	0	0	0.00499	0	12	125										A	96274734	G	A	96274734	4	1	110	1	0	0	0	0	0	1	0	0	4863	1333	46	2	1690	2	DZIP1	13	96274734	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	24221294	96274734	18895144	291	33803										
MBNL2	10150	broad.mit.edu	37	chr13	97999162	97999162	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacacaagtgacaacaccgtAaccgtttgtatggattacat	8	9	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:97999162A>G	uc010aft.2	+	5	1461	c.645A>G	c.(643-645)GTA>GTG	p.V215V	MBNL2_uc001vmz.2_Silent_p.V215V|MBNL2_uc001vna.2_Silent_p.V215V|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Intron|MBNL2_uc001vnc.2_5'Flank	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	215	C3H1-type 4.				mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			ACAACACCGTAACCGTTTGTA	0.537													0	0	0	0.004007	0	14	102										G	97999162	A	G	97999162	2	3	110	1	0	0	0	0	0	0	0	1	9354	349	13	5		5	MBNL2	13	97999162	Silent	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	1724428	97999162	17170716	292	33804										
UBAC2	337867	broad.mit.edu	37	chr13	99992667	99992667	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aattcttttcttggacacttGaacccatcttctcttcttca	3	12	6	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:99992667G>C	uc001voa.3	+	7	1139	c.655G>C	c.(655-657)GAA>CAA	p.E219Q	UBAC2_uc010tiu.1_Missense_Mutation_p.E241Q|UBAC2_uc001vob.3_Missense_Mutation_p.E192Q|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Missense_Mutation_p.E106Q|UBAC2_uc001voc.2_Missense_Mutation_p.E184Q|UBAC2_uc010tiw.1_RNA|UBAC2_uc001voh.2_Missense_Mutation_p.E23Q	NM_001144072	NP_001137544	Q8NBM4	UBAC2_HUMAN	UBA domain containing 2 isoform 1	219	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTGGACACTTGAACCCATCTT	0.527													0	0	0	0.000602	0	4	94										C	99992667	G	C	99992667	3	2	110	1	0	0	0	0	1	0	0	0	16832	1291	45	1	841	1	UBAC2	13	99992667	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1993505	99992667	15177211	293	33805										
ZIC2	7546	broad.mit.edu	37	chr13	100637333	100637333	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgtgcgacaagtcctacacGcaccccagctcgctgcggaa	10	15	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:100637333G>A	uc001von.2	+	2	1209	c.1209G>A	c.(1207-1209)ACG>ACA	p.T403T		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	403	C2H2-type 5.		T -> K (in HPE5).		brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AGTCCTACACGCACCCCAGCT	0.667													0	0	0	0.004007	0	13	124										A	100637333	G	A	100637333	2	1	110	1	0	0	0	0	0	0	0	1	17676	1074	38	2		2	ZIC2	13	100637333	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	644666	100637333	14532545	294	33806										
EFNB2	1948	broad.mit.edu	37	chr13	107147270	107147270	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacttgttgtcgaacttcttCcatttgtaccagcttctagt	7	10	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:107147270C>A	uc001vqi.2	-	4	597	c.572G>T	c.(571-573)GGA>GTA	p.G191V		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	191	Extracellular (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					CGAACTTCTTCCATTTGTACC	0.393													1	0	5.01169e-05	0.00499	5.26492e-05	13	225										A	107147270	C	A	107147270	3	1	110	1	0	0	0	0	1	0	0	0	4956	855	30	3	437	3	EFNB2	13	107147270	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	6509937	107147270	8022608	295	33807										
CARS2	79587	broad.mit.edu	37	chr13	111296814	111296814	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caccaaacacagcaggacttCtcggcccttcaggttcctgt	8	15	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr13:111296814C>T	uc001vrd.2	-	13	1374	c.1334G>A	c.(1333-1335)AGA>AAA	p.R445K	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	445					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	AGCAGGACTTCTCGGCCCTTC	0.423													0	0	0	0.001984	0	5	65										T	111296814	C	T	111296814	3	4	110	1	0	0	0	0	1	0	0	0	2658	913	32	1	372	1	CARS2	13	111296814	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4149544	111296814	3873064	296	33808										
TOX4	9878	broad.mit.edu	37	chr14	21960463	21960463	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcttttttgcaggtatataaGaggaaaactgaggctgccaa	10	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:21960463G>A	uc001waz.2	+	6	922	c.819G>A	c.(817-819)AAG>AAA	p.K273K	TOX4_uc001way.2_Silent_p.K143K|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Silent_p.K250K|TOX4_uc010tlv.1_Silent_p.K143K	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	273	HMG box.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		AGGTATATAAGAGGAAAACTG	0.358													0	0	0	0.006214	0	8	84										A	21960463	G	A	21960463	2	1	110	1	0	0	0	0	0	0	0	1	16377	933	33	1		1	TOX4	14	21960463	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		21960463	85389077	297	33809										
MIPOL1	145282	broad.mit.edu	37	chr14	37969203	37969203	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaagctttaaaaaacagagaGaacattgtttccatcactca	6	8	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:37969203G>C	uc001wuc.2	+	13	1625	c.1122G>C	c.(1120-1122)GAG>GAC	p.E374D	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Missense_Mutation_p.E343D|MIPOL1_uc001wud.2_Missense_Mutation_p.E374D|MIPOL1_uc010ams.2_Missense_Mutation_p.E374D|MIPOL1_uc001wue.2_Missense_Mutation_p.E343D|MIPOL1_uc010amt.2_Missense_Mutation_p.E193D	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	374	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAAACAGAGAGAACATTGTTT	0.348													0	0	0	0.001168	0	5	101										C	37969203	G	C	37969203	3	2	110	1	0	0	0	0	1	0	0	0	9593	933	33	1	1160	1	MIPOL1	14	37969203	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	16008740	37969203	69380337	298	33810										
PSMC6	5706	broad.mit.edu	37	chr14	53187697	53187697	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggaagattagatagaaaaaTacgtgagttaagattcttta	9	2	1	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:53187697T>G	uc010tqx.1	+	11	938	c.938T>G	c.(937-939)ATA>AGA	p.I313R	PSMC6_uc001wzy.2_5'Flank	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	299					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					GATAGAAAAATACGTGAGTTA	0.368													0	0	0	0.001855	0	10	192										G	53187697	T	G	53187697	3	3	110	1	0	0	0	0	1	0	0	0	12691	1406	49	5	980	5	PSMC6	14	53187697	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	15218494	53187697	54161843	299	33811										
WDHD1	11169	broad.mit.edu	37	chr14	55429799	55429799	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtattaatttccgagagcgaGaagcatatttaatggctaaa	9	5	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:55429799G>C	uc001xbm.1	-	19	2480	c.2402C>G	c.(2401-2403)TCT>TGT	p.S801C	WDHD1_uc010aom.1_Missense_Mutation_p.S318C|WDHD1_uc001xbn.1_Missense_Mutation_p.S678C	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	801						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CCGAGAGCGAGAAGCATATTT	0.383													0	0	0	0.001984	0	6	73										C	55429799	G	C	55429799	3	2	110	1	0	0	0	0	1	0	0	0	17268	942	33	1	1019	1	WDHD1	14	55429799	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2242102	55429799	51919741	300	33812										
KTN1	3895	broad.mit.edu	37	chr14	56122763	56122763	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttgtaaaaaattctaggttGaaagaaaaggaaaatgaatt	8	1	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:56122763G>A	uc001xcb.2	+	30	3107	c.2805G>A	c.(2803-2805)TTG>TTA	p.L935L	KTN1_uc001xce.2_Silent_p.L935L|KTN1_uc001xcc.2_Silent_p.L935L|KTN1_uc001xcd.2_Silent_p.L912L|KTN1_uc010trb.1_Silent_p.L935L|KTN1_uc001xcf.1_Silent_p.L912L|KTN1_uc010aoq.2_Silent_p.L230L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	935	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						ATTCTAGGTTGAAAGAAAAGG	0.348			T	RET	papillary thryoid								0	0	0	0.000602	0	4	21										A	56122763	G	A	56122763	2	1	110	1	0	0	0	0	0	0	0	1	8585	1281	45	1		1	KTN1	14	56122763	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	692964	56122763	51226777	301	33813										
RTN1	6252	broad.mit.edu	37	chr14	60213112	60213112	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaggtggatagcagatgtcaGaaatgagagatgtgtaacac	14	4	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:60213112G>C	uc001xen.1	-	2	538	c.329C>G	c.(328-330)TCT>TGT	p.S110C		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	110					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GCAGATGTCAGAAATGAGAGA	0.458													0	0	0	0.001984	0	6	57										C	60213112	G	C	60213112	3	2	110	1	0	0	0	0	1	0	0	0	13725	942	33	1	2098	1	RTN1	14	60213112	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4090349	60213112	47136428	302	33814										
NEK9	91754	broad.mit.edu	37	chr14	75590902	75590902	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagccgggtcaaatcgacttCcttccacacaaccagtgagt	8	14	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:75590902C>T	uc001xrl.2	-	2	398	c.244G>A	c.(244-246)GAA>AAA	p.E82K		NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	82	Protein kinase.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		AAATCGACTTCCTTCCACACA	0.473													0	0	0	0.001984	0	6	60										T	75590902	C	T	75590902	3	4	110	1	0	0	0	0	1	0	0	0	10331	864	30	1	2779	1	NEK9	14	75590902	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	15377790	75590902	31758638	303	33815										
SERPINA11	256394	broad.mit.edu	37	chr14	94914814	94914814	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gttgaatcccaggccctccaGgatcagagctgaggtgttag	13	10	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:94914814G>T	uc001ydd.1	-	2	358	c.298C>A	c.(298-300)CTG>ATG	p.L100M		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	100					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		AGGCCCTCCAGGATCAGAGCT	0.617													1	0	0.000442599	0.006214	0.000457261	9	77										T	94914814	G	T	94914814	3	4	110	1	0	0	0	0	1	0	0	0	14088	991	35	4	986	4	SERPINA11	14	94914814	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	19323912	94914814	12434726	304	33816										
PAPOLA	10914	broad.mit.edu	37	chr14	97003351	97003351	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaattttgctgagtaaggcaGagtggtccaaactttttgaa	10	5	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:97003351G>A	uc001yfq.2	+	12	1279	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	PAPOLA_uc001yfr.2_Missense_Mutation_p.E357K|PAPOLA_uc010twv.1_Missense_Mutation_p.E357K|PAPOLA_uc010avp.2_Missense_Mutation_p.E107K	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	357					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		GAGTAAGGCAGAGTGGTCCAA	0.313													0	0	0	0.001984	0	5	51										A	97003351	G	A	97003351	3	1	110	1	0	0	0	0	1	0	0	0	11429	943	33	1	1115	1	PAPOLA	14	97003351	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2088537	97003351	10346189	305	33817										
C14orf177	283598	broad.mit.edu	37	chr14	99183486	99183486	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aatcagaatgccagagacatGaagaaacttctccagggtca	9	9	3	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:99183486G>T	uc001yfz.1	+	4	672	c.253G>T	c.(253-255)GAA>TAA	p.E85*		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	85											0		Melanoma(154;0.128)				CCAGAGACATGAAGAAACTTC	0.453													1	0	1.06961e-07	0.00308	1.1503e-07	5	70										T	99183486	G	T	99183486	4	4	110	1	0	0	0	0	0	1	0	0	1760	1291	45	3	259	3	C14orf177	14	99183486	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2180135	99183486	8166054	306	33818										
C14orf73	91828	broad.mit.edu	37	chr14	103574805	103574805	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgggcgagacctacaaagatGacatccagcggcacctggag	13	11	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr14:103574805G>T	uc001ymk.2	+	10	2003	c.1927G>T	c.(1927-1929)GAC>TAC	p.D643Y		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	643											0		Melanoma(154;0.155)	Epithelial(46;0.221)			CTACAAAGATGACATCCAGCG	0.602													1	0	7.41877e-09	0.001882	8.0303e-09	21	315										T	103574805	G	T	103574805	3	4	110	1	0	0	0	0	1	0	0	0	1779	1290	45	3	1965	3	C14orf73	14	103574805	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4391319	103574805	3774735	307	33819										
HERC2	8924	broad.mit.edu	37	chr15	28408392	28408392	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtgaactcatccaaggcctGaggctccggacctgctgctt	12	13	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:28408392G>A	uc001zbj.2	-	69	10700	c.10594C>T	c.(10594-10596)CAG>TAG	p.Q3532*		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3532					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCCAAGGCCTGAGGCTCCGGA	0.502													0	0	0	0.00308	0	7	108										A	28408392	G	A	28408392	4	1	110	1	0	0	0	0	0	1	0	0	7058	1299	45	1	4010	1	HERC2	15	28408392	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		28408392	74123000	308	33820										
C15orf23	90417	broad.mit.edu	37	chr15	40675233	40675233	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaggactgcgggcaggaccGgcgggctcctgggttcggct	19	11	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:40675233G>A	uc001zll.2	+	1	312	c.197G>A	c.(196-198)CGG>CAG	p.R66Q	C15orf23_uc010ucp.1_Missense_Mutation_p.R66Q|C15orf23_uc001zlo.2_Missense_Mutation_p.R66Q|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	66						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		GGGCAGGACCGGCGGGCTCCT	0.592													0	0	0	0.008291	0	10	136										A	40675233	G	A	40675233	3	1	110	1	0	0	0	0	1	0	0	0	1785	1116	39	2	199	2	C15orf23	15	40675233	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	12266841	40675233	61856159	309	33821										
SNAP23	8773	broad.mit.edu	37	chr15	42821985	42821985	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taggcaatgagattgatgctCaaaatccacaaataaaacga	7	7	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:42821985C>G	uc001zpz.1	+	7	629	c.538C>G	c.(538-540)CAA>GAA	p.Q180E	SNAP23_uc001zqa.1_Missense_Mutation_p.Q127E	NM_003825	NP_003816	O00161	SNP23_HUMAN	synaptosomal-associated protein 23 isoform	180	t-SNARE coiled-coil homology 2.				cellular membrane fusion|post-Golgi vesicle-mediated transport|protein transport|vesicle targeting	azurophil granule|cell junction|Golgi apparatus|nucleus|plasma membrane enriched fraction|specific granule|synapse|synaptosome	protein binding				0		all_cancers(109;7.14e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;1.18e-08)|all_lung(180;4.2e-08)|Melanoma(134;0.0179)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;2.62e-06)		GATTGATGCTCAAAATCCACA	0.403													0	0	0	0.000602	0	5	72										G	42821985	C	G	42821985	3	3	110	1	0	0	0	0	1	0	0	0	14829	827	29	1	560	1	SNAP23	15	42821985	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2146752	42821985	59709407	310	33822										
DMXL2	23312	broad.mit.edu	37	chr15	51772766	51772766	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gattcttgtagcaaaaatttGagttccatccttactgaagc	7	8	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:51772766G>C	uc002abf.2	-	24	6762	c.6537C>G	c.(6535-6537)CTC>CTG	p.L2179L	DMXL2_uc002abd.2_Silent_p.L249L|DMXL2_uc010ufy.1_Silent_p.L2179L|DMXL2_uc010bfa.2_Silent_p.L1543L	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2179						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GCAAAAATTTGAGTTCCATCC	0.393													0	0	0	0.00308	0	6	64										C	51772766	G	C	51772766	2	2	110	1	0	0	0	0	0	0	0	1	4595	1277	45	1		1	DMXL2	15	51772766	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	8950781	51772766	50758626	311	33823										
TRIP4	9325	broad.mit.edu	37	chr15	64689913	64689913	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tccctggtcgtcacccttgtGattgcctgggccagaagcac	11	14	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:64689913G>A	uc002anm.2	+	4	557	c.514G>A	c.(514-516)GAT>AAT	p.D172N		NM_016213	NP_057297	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	172	C4-type.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3						TCACCCTTGTGATTGCCTGGG	0.498													0	0	0	0.001168	0	6	84										A	64689913	G	A	64689913	3	1	110	1	0	0	0	0	1	0	0	0	16555	1290	45	1	528	1	TRIP4	15	64689913	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	12917147	64689913	37841479	312	33824										
SMAD6	4091	broad.mit.edu	37	chr15	67073574	67073574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcctgctcagcaaggagcccGacggcgtgtgggcctacaac	13	14	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:67073574G>A	uc002aqf.2	+	4	2115	c.1192G>A	c.(1192-1194)GAC>AAC	p.D398N	SMAD6_uc010bhx.2_RNA|SMAD6_uc002aqg.2_Missense_Mutation_p.D137N	NM_005585	NP_005576	O43541	SMAD6_HUMAN	SMAD family member 6 isoform 1	398	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			skin(1)	1						CAAGGAGCCCGACGGCGTGTG	0.711													0	0	0	0.00308	0	5	36										A	67073574	G	A	67073574	3	1	110	1	0	0	0	0	1	0	0	0	14762	1058	37	1	1244	1	SMAD6	15	67073574	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2383661	67073574	35457818	313	33825										
UACA	55075	broad.mit.edu	37	chr15	70959792	70959792	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttctttacttccgtgtatttCtgtgacaagtcttttaactg	6	8	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:70959792C>G	uc002asr.2	-	16	3335	c.3231G>C	c.(3229-3231)CAG>CAC	p.Q1077H	UACA_uc010uke.1_Missense_Mutation_p.Q968H|UACA_uc002asq.2_Missense_Mutation_p.Q1064H|UACA_uc010bin.1_Missense_Mutation_p.Q1052H	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1077	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CCGTGTATTTCTGTGACAAGT	0.358													0	0	0	0.001984	0	7	51										G	70959792	C	G	70959792	3	3	110	1	0	0	0	0	1	0	0	0	16821	912	32	1	1035	1	UACA	15	70959792	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3886218	70959792	31571600	314	33826										
AGBL1	123624	broad.mit.edu	37	chr15	86814885	86814885	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tatattctgtgaaggaggctCttcttggcaaacccacctgg	10	10	3	1	rs147544569	by1000genomes	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:86814885C>G	uc002blz.1	+	14	1965	c.1885C>G	c.(1885-1887)CTT>GTT	p.L629V	AGBL1_uc002bma.1_Missense_Mutation_p.L360V|AGBL1_uc002bmb.1_Missense_Mutation_p.L323V	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	629					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GAAGGAGGCTCTTCTTGGCAA	0.388													0	0	0	0.003163	0	10	125										G	86814885	C	G	86814885	3	3	110	1	0	0	0	0	1	0	0	0	375	913	32	1	1935	1	AGBL1	15	86814885	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	15855093	86814885	15716507	315	33827										
ACAN	176	broad.mit.edu	37	chr15	89403660	89403660	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctggctacactggcgagcaCtgtaacataggtaaggccct	11	12	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:89403660C>T	uc010upo.1	+	13	7310	c.6936C>T	c.(6934-6936)CAC>CAT	p.H2312H	ACAN_uc010upp.1_Intron|ACAN_uc002bna.2_Intron	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2312					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGCGAGCACTGTAACATAG	0.627													0	0	0	0.000602	0	3	31										T	89403660	C	T	89403660	2	4	110	1	0	0	0	0	0	0	0	1	117	564	20	2		2	ACAN	15	89403660	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2588775	89403660	13127732	316	33828										
MFGE8	4240	broad.mit.edu	37	chr15	89442994	89442994	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gacagagccaaagttacgggCcccctgggtgatgatgcctg	14	11	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:89442994C>A	uc002bng.3	-	7	1032	c.919G>T	c.(919-921)GCC>TCC	p.A307S	MFGE8_uc002bnf.3_Missense_Mutation_p.A195S|MFGE8_uc002bnh.3_Intron|MFGE8_uc010bnn.2_Missense_Mutation_p.A299S|MFGE8_uc010upq.1_Missense_Mutation_p.A263S|MFGE8_uc010upr.1_Missense_Mutation_p.A307S	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	307	F5/8 type C 2.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					AAGTTACGGGCCCCCTGGGTG	0.542													1	0	8.12818e-05	0.001984	8.50307e-05	7	50										A	89442994	C	A	89442994	3	1	110	1	0	0	0	0	1	0	0	0	9520	739	26	4	252	4	MFGE8	15	89442994	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	39334	89442994	13088398	317	33829										
KIF7	374654	broad.mit.edu	37	chr15	90189215	90189215	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acttcccagcctgttcacctCagtcagcaactcagctccag	6	17	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:90189215C>T	uc002bof.2	-	8	1908	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K	KIF7_uc010upw.1_Missense_Mutation_p.E98K	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	611					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGTTCACCTCAGTCAGCAAC	0.517													0	0	0	0.00499	0	13	160										T	90189215	C	T	90189215	3	4	110	1	0	0	0	0	1	0	0	0	8309	835	29	1	2248	1	KIF7	15	90189215	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	746221	90189215	12342177	318	33830										
BLM	641	broad.mit.edu	37	chr15	91333991	91333991	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttactaccaagaatctggcaGagctggaagagatggggaaa	13	6	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:91333991G>C	uc002bpr.2	+	15	3033	c.2936G>C	c.(2935-2937)AGA>ACA	p.R979T	BLM_uc010uqh.1_Missense_Mutation_p.R979T|BLM_uc010uqi.1_Missense_Mutation_p.R604T|BLM_uc010bnx.2_Missense_Mutation_p.R979T|BLM_uc002bps.1_Missense_Mutation_p.R541T	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	979	Helicase C-terminal.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			GAATCTGGCAGAGCTGGAAGA	0.438			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				0	0	0	0.004482	0	9	105										C	91333991	G	C	91333991	3	2	110	1	0	0	0	0	1	0	0	0	1445	942	33	1	2990	1	BLM	15	91333991	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1144776	91333991	11197401	319	33831										
SV2B	9899	broad.mit.edu	37	chr15	91769716	91769716	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctccagaatggacagccttCggggccagacagacctgatg	12	13	0	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:91769716C>T	uc002bqv.2	+	1	614	c.223C>T	c.(223-225)CGG>TGG	p.R75W	SV2B_uc002bqt.2_Missense_Mutation_p.R75W|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	75	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGACAGCCTTCGGGGCCAGAC	0.587													0	0	0	0.001168	0	4	32										T	91769716	C	T	91769716	3	4	110	1	0	0	0	0	1	0	0	0	15415	875	31	1	225	1	SV2B	15	91769716	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	435725	91769716	10761676	320	33832										
LINS1	55180	broad.mit.edu	37	chr15	101109865	101109866	+	Frame_Shift_Del	DEL	AC	AC	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttgagaggcccggggggaagAcagactagaagcacacatgg					rs146405261	byFrequency	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr15:101109865_101109866delAC	uc002bwe.2	-	8	2142_2143	c.1851_1852delGT	c.(1849-1854)CTGTCTfs	p.L617fs	LINS1_uc002bwd.2_Frame_Shift_Del_p.L204fs|LINS1_uc002bwf.2_Frame_Shift_Del_p.L617fs|LINS1_uc002bwg.2_Frame_Shift_Del_p.L617fs|LINS1_uc002bwh.2_Frame_Shift_Del_p.L617fs	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	617_618											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			CGGGGGGAAGACAGACTAGAAG	0.53																		7	95	---	---								-	101109866	AC	-	101109865	7	5	110	1	0	1	0	1	0	0	0	0	8818	275	10	0	425	0	LINS1	15	101109865	Frame_Shift_Del	DEL	AC	TCGA-GD-A3OP-01A-21D-A21Z-08	9340149	101109865	1421527	321	33833										
ITFG3	83986	broad.mit.edu	37	chr16	312519	312520	+	Missense_Mutation	DNP	TC	TC	CT													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cccgcactgggagagcatgcTcaatgccaccacccgcagga							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:312519_312520TC>CT	uc002cgf.2	+	8	1133_1134	c.938_939TC>CT	c.(937-939)CTC>CCT	p.L313P	ITFG3_uc010bqr.2_RNA|ITFG3_uc002cgg.2_Missense_Mutation_p.L313P|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.L313P	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	313	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				GAGAGCATGCTCAATGCCACCA	0.649													0	0	0	0.004672	0	11	88										CT	312520	TC	CT	312519	3	2	110	1	0	0	0	0	1	0	0	0	7871	1551	54	5	960	5	ITFG3	16	312519	Missense_Mutation	DNP	TC	TCGA-GD-A3OP-01A-21D-A21Z-08		312519	90042234	322	33834										
UNKL	64718	broad.mit.edu	37	chr16	1417786	1417786	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaggatggggggccggcactCaggatgggggaggggctggg	25	6	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:1417786C>G	uc010brn.1	-	7	798	c.780G>C	c.(778-780)CTG>CTC	p.L260L	UNKL_uc002cln.2_Silent_p.L52L|UNKL_uc002clo.2_Silent_p.L49L|UNKL_uc002clp.2_Silent_p.L52L			Q9H9P5	UNKL_HUMAN	SubName: Full=Putative ubiquitin-protein ligase;          EC=6.3.2.19; Flags: Fragment;	550	Ser-rich.					cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				GGCCGGCACTCAGGATGGGGG	0.642													0	0	0	0.004672	0	3	9										G	1417786	C	G	1417786	2	3	110	1	0	0	0	0	0	0	0	1	16998	813	29	1		1	UNKL	16	1417786	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1105267	1417786	88936967	323	33835										
TBC1D24	57465	broad.mit.edu	37	chr16	2546157	2546157	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcacagcggcgctatggactCtccaggatacaactgcttcg	11	13	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:2546157C>G	uc002cql.2	+	2	148	c.8C>G	c.(7-9)TCT>TGT	p.S3C	TBC1D24_uc002cqk.2_Missense_Mutation_p.S3C|TBC1D24_uc002cqm.2_Missense_Mutation_p.S3C|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	3					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						GCTATGGACTCTCCAGGATAC	0.597													0	0	0	0.004656	0	16	109										G	2546157	C	G	2546157	3	3	110	1	0	0	0	0	1	0	0	0	15611	913	32	1	10	1	TBC1D24	16	2546157	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1128371	2546157	87808596	324	33836										
NMRAL1	57407	broad.mit.edu	37	chr16	4511851	4511851	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcagggccttggggttgagtCtcagggtcagctcgatgtca	15	9	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:4511851C>T	uc002cwm.2	-	6	986	c.830G>A	c.(829-831)AGA>AAA	p.R277K	NMRAL1_uc002cwn.2_Missense_Mutation_p.R277K|NMRAL1_uc002cwo.2_Missense_Mutation_p.R277K|NMRAL1_uc002cwp.2_Missense_Mutation_p.R313K	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	277						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						GGGGTTGAGTCTCAGGGTCAG	0.617													0	0	0	0.001855	0	12	232										T	4511851	C	T	4511851	3	4	110	1	0	0	0	0	1	0	0	0	10501	913	32	1	73	1	NMRAL1	16	4511851	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1965694	4511851	85842902	325	33837										
CLEC16A	23274	broad.mit.edu	37	chr16	11137897	11137897	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttaacagggtgcgagagaaGaaagtgttcaccttgtacga	12	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:11137897G>A	uc002dao.2	+	16	2013	c.1783G>A	c.(1783-1785)GAA>AAA	p.E595K	CLEC16A_uc002dan.3_Missense_Mutation_p.E577K	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	595								p.0?(1)		ovary(1)|central_nervous_system(1)	2						TGCGAGAGAAGAAAGTGTTCA	0.443													0	0	0	0.001368	0	10	73										A	11137897	G	A	11137897	3	1	110	1	0	0	0	0	1	0	0	0	3500	943	33	1	1841	1	CLEC16A	16	11137897	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6626046	11137897	79216856	326	33838										
TXNDC11	51061	broad.mit.edu	37	chr16	11824584	11824584	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacccggcggacaaacttctCaatgtaaacagcactcatgg	8	13	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:11824584C>G	uc010buu.1	-	4	678	c.616G>C	c.(616-618)GAG>CAG	p.E206Q	TXNDC11_uc002dbg.1_Missense_Mutation_p.E206Q	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	206	Thioredoxin 1.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						ACAAACTTCTCAATGTAAACA	0.343													0	0	0	0.000602	0	5	115										G	11824584	C	G	11824584	3	3	110	1	0	0	0	0	1	0	0	0	16789	835	29	1	2296	1	TXNDC11	16	11824584	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	686687	11824584	78530169	327	33839										
ABCC1	4363	broad.mit.edu	37	chr16	16219752	16219752	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggagaggctcaaggagtattCagagactgagaaggaggtag	17	4	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:16219752C>T	uc010bvi.2	+	26	3978	c.3803C>T	c.(3802-3804)TCA>TTA	p.S1268L	ABCC1_uc010bvj.2_Missense_Mutation_p.S1209L|ABCC1_uc010bvk.2_Missense_Mutation_p.S1212L|ABCC1_uc010bvl.2_Missense_Mutation_p.S1268L|ABCC1_uc010bvm.2_Missense_Mutation_p.S1153L|ABCC1_uc002del.3_Missense_Mutation_p.S1162L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1268	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AAGGAGTATTCAGAGACTGAG	0.537													0	0	0	0.00308	0	6	54										T	16219752	C	T	16219752	3	4	110	1	0	0	0	0	1	0	0	0	49	838	29	1	3905	1	ABCC1	16	16219752	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4395168	16219752	74135001	328	33840										
MAPK3	5595	broad.mit.edu	37	chr16	30134420	30134420	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgcgtgtagcgcgggcccacGtcgaacggctgccccttcac	13	16	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:30134420G>A	uc002dws.2	-	1	211	c.111C>T	c.(109-111)GAC>GAT	p.D37D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_5'Flank|MAPK3_uc002dwv.3_Silent_p.D37D|MAPK3_uc002dwt.2_Silent_p.D37D|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	37					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GCGGGCCCACGTCGAACGGCT	0.627													0	0	0	0.001168	0	4	42										A	30134420	G	A	30134420	2	1	110	1	0	0	0	0	0	0	0	1	9279	1136	40	2		2	MAPK3	16	30134420	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	13914668	30134420	60220333	329	33841										
SRCAP	10847	broad.mit.edu	37	chr16	30735318	30735318	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcagacacctggtcaccctCtgttgttggctcccacctct	7	17	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:30735318C>G	uc002dze.1	+	25	4958	c.4573C>G	c.(4573-4575)CTG>GTG	p.L1525V	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.L1320V|SRCAP_uc010bzz.1_Missense_Mutation_p.L1095V	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1525	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGGTCACCCTCTGTTGTTGGC	0.587													0	0	0	0.001168	0	5	41										G	30735318	C	G	30735318	3	3	110	1	0	0	0	0	1	0	0	0	15134	912	32	1	4663	1	SRCAP	16	30735318	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	600898	30735318	59619435	330	33842										
CHD9	80205	broad.mit.edu	37	chr16	53338213	53338213	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agaaatctggtggaaaatgtGaaacagacagacgcatggtt	12	5	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:53338213G>A	uc002ehb.2	+	30	6459	c.6295G>A	c.(6295-6297)GAA>AAA	p.E2099K	CHD9_uc002egy.2_Missense_Mutation_p.E2099K|CHD9_uc002ehc.2_Missense_Mutation_p.E2099K|CHD9_uc002ehf.2_Missense_Mutation_p.E1213K|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_Missense_Mutation_p.E105K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2099					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				TGGAAAATGTGAAACAGACAG	0.448													0	0	0	0.004672	0	3	23										A	53338213	G	A	53338213	3	1	110	1	0	0	0	0	1	0	0	0	3332	1291	45	1	6413	1	CHD9	16	53338213	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	22602895	53338213	37016540	331	33843										
FUK	197258	broad.mit.edu	37	chr16	70500855	70500855	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gctgtctgttcctgcaaatcCtggtgagcctgagactacct	10	12	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:70500855C>T	uc002eyy.2	+	6	540	c.482C>T	c.(481-483)CCT>CTT	p.P161L	FUK_uc010vmb.1_Missense_Mutation_p.P144L|FUK_uc010cft.2_Missense_Mutation_p.P193L|FUK_uc002eyz.2_Intron	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	161						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				CCTGCAAATCCTGGTGAGCCT	0.647													0	0	0	0.008291	0	9	77										T	70500855	C	T	70500855	3	4	110	1	0	0	0	0	1	0	0	0	6096	681	24	2	500	2	FUK	16	70500855	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	17162642	70500855	19853898	332	33844										
PLCG2	5336	broad.mit.edu	37	chr16	81929432	81929432	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggactgctgggacgggcccGatgggaagccggtcatctac	16	11	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr16:81929432G>C	uc002fgt.2	+	13	1245	c.1093G>C	c.(1093-1095)GAT>CAT	p.D365H	PLCG2_uc010chg.1_Missense_Mutation_p.D365H	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	365	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						GGACGGGCCCGATGGGAAGCC	0.607													0	0	0	0.00308	0	6	87										C	81929432	G	C	81929432	3	2	110	1	0	0	0	0	1	0	0	0	12036	1058	37	1	1139	1	PLCG2	16	81929432	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	11428577	81929432	8425321	333	33845										
OR1D2	4991	broad.mit.edu	37	chr17	2995465	2995465	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gggtgtcaccacagcatacaTcactgtggctactgagtcct	10	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:2995465T>A	uc010vrb.1	-	1	826	c.826A>T	c.(826-828)ATG>TTG	p.M276L		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	276	Helical; Name=7; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						ACAGCATACATCACTGTGGCT	0.483													0	0	0	0.000978	0	9	113										A	2995465	T	A	2995465	3	1	110	1	0	0	0	0	1	0	0	0	10953	1435	50	5	115	5	OR1D2	17	2995465	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08		2995465	78199745	334	33846										
ASGR2	433	broad.mit.edu	37	chr17	7017471	7017471	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcctctcctgggattcagcCtgcgagtgcctggcccctca	10	16	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7017471C>T	uc002gep.3	-	2	354	c.89G>A	c.(88-90)AGG>AAG	p.R30K	ASGR2_uc002gem.1_5'UTR|ASGR2_uc002gen.1_Intron|ASGR2_uc002geo.1_Missense_Mutation_p.R30K|ASGR2_uc002ger.3_Missense_Mutation_p.R30K|ASGR2_uc002geq.3_Intron|ASGR2_uc010clw.2_Intron|ASGR2_uc010vtl.1_Intron	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	30	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	GGGATTCAGCCTGCGAGTGCC	0.493													0	0	0	0.001855	0	11	115										T	7017471	C	T	7017471	3	4	110	1	0	0	0	0	1	0	0	0	1040	681	24	2	878	2	ASGR2	17	7017471	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4022006	7017471	74177739	335	33847										
DVL2	1856	broad.mit.edu	37	chr17	7131015	7131015	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atgtaatggtgctcatggagGaggaacctggataggctggg	17	5	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7131015G>A	uc002gez.1	-	11	1472	c.1190C>T	c.(1189-1191)TCC>TTC	p.S397F	DVL2_uc010vtr.1_Missense_Mutation_p.S391F	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	397					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						GCTCATGGAGGAGGAACCTGG	0.597													0	0	0	0.004672	0	3	37										A	7131015	G	A	7131015	3	1	110	1	0	0	0	0	1	0	0	0	4836	1174	41	1	1040	1	DVL2	17	7131015	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	113544	7131015	74064195	336	33848										
SAT2	112483	broad.mit.edu	37	chr17	7530510	7530510	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tctgctaccaaacagtgataGaaaggattgtctccaaagcc	8	10	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7530510G>C	uc002gic.2	-	3	394	c.153C>G	c.(151-153)TTC>TTG	p.F51L	SHBG_uc010cmo.2_Intron|SHBG_uc010cmp.2_Intron|SHBG_uc010cmq.2_Intron|SHBG_uc010cmr.2_Intron|SHBG_uc010cms.2_Intron|SHBG_uc010cmt.2_Intron|SHBG_uc010cmu.2_Intron|SAT2_uc002gib.1_RNA|SHBG_uc010cmz.2_5'Flank|SHBG_uc010cmv.2_5'Flank|SHBG_uc010cmw.2_5'Flank|SHBG_uc010cmx.2_5'Flank|SHBG_uc010cmy.2_5'Flank|SHBG_uc002gid.3_5'Flank|SHBG_uc002gie.2_5'Flank|SHBG_uc010cnd.2_5'Flank|SHBG_uc010cna.2_5'Flank|SHBG_uc010vue.1_5'Flank|SHBG_uc010vuf.1_5'Flank|SHBG_uc010cnb.2_5'Flank|SHBG_uc010cnc.2_5'Flank	NM_133491	NP_597998	Q96F10	SAT2_HUMAN	diamine N-acetyltransferase 2	51	N-acetyltransferase.					cytoplasm	diamine N-acetyltransferase activity	p.?(1)			0				READ - Rectum adenocarcinoma(115;0.166)	Spermine(DB00127)	AACAGTGATAGAAAGGATTGT	0.547													0	0	0	0.00308	0	7	80										C	7530510	G	C	7530510	3	2	110	1	0	0	0	0	1	0	0	0	13852	933	33	1	375	1	SAT2	17	7530510	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	399495	7530510	73664700	337	33849										
DNAH2	146754	broad.mit.edu	37	chr17	7643790	7643790	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgacccagaacctgatcaccTcagccttcgagttggtgcgg	11	13	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7643790T>C	uc002giu.1	+	9	1443	c.1429T>C	c.(1429-1431)TCA>CCA	p.S477P	DNAH2_uc002git.2_Missense_Mutation_p.S559P|DNAH2_uc010vuk.1_Missense_Mutation_p.S477P	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	477	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCTGATCACCTCAGCCTTCGA	0.667													0	0	0	0.004007	0	13	219										C	7643790	T	C	7643790	3	2	110	1	0	0	0	0	1	0	0	0	4602	1551	54	5	1463	5	DNAH2	17	7643790	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	113280	7643790	73551420	338	33850										
DNAH2	146754	broad.mit.edu	37	chr17	7674653	7674653	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttttggccccctcagaatatCttcctaggagaagacatccg	8	12	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:7674653C>T	uc002giu.1	+	27	4382	c.4368C>T	c.(4366-4368)ATC>ATT	p.I1456I		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1456	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTCAGAATATCTTCCTAGGAG	0.512													0	0	0	0.00632	0	20	152										T	7674653	C	T	7674653	2	4	110	1	0	0	0	0	0	0	0	1	4602	903	32	1		1	DNAH2	17	7674653	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	30863	7674653	73520557	339	33851										
SPDYE4	388333	broad.mit.edu	37	chr17	8659711	8659711	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cttaccttgtctgacaccctCaggtctttgtcccaggccag	8	15	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:8659711C>T	uc010cnz.1	-	3	561	c.384G>A	c.(382-384)CTG>CTA	p.L128L		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	128											0						CTGACACCCTCAGGTCTTTGT	0.527													0	0	0	0.004007	0	14	156										T	8659711	C	T	8659711	2	4	110	1	0	0	0	0	0	0	0	1	15030	813	29	1		1	SPDYE4	17	8659711	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	985058	8659711	72535499	340	33852										
TOM1L2	146691	broad.mit.edu	37	chr17	17754256	17754256	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cgtccatgacagatggctgcGcaacggggatctatggaggc	15	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:17754256G>A	uc002grz.3	-	13	1446	c.1289C>T	c.(1288-1290)GCG>GTG	p.A430V	TOM1L2_uc002gry.3_Missense_Mutation_p.A380V|TOM1L2_uc010vwy.1_Missense_Mutation_p.A406V|TOM1L2_uc010cpr.2_Missense_Mutation_p.A385V|TOM1L2_uc010vwz.1_Missense_Mutation_p.A311V|TOM1L2_uc010vxa.1_Intron|TOM1L2_uc002grv.3_Missense_Mutation_p.A163V	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	430					intracellular protein transport	intracellular					0	all_neural(463;0.228)					AGATGGCTGCGCAACGGGGAT	0.587													0	0	0	0.004007	0	14	121										A	17754256	G	A	17754256	3	1	110	1	0	0	0	0	1	0	0	0	16350	1087	38	2	246	2	TOM1L2	17	17754256	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9094545	17754256	63440954	341	33853										
EPN2	22905	broad.mit.edu	37	chr17	19186762	19186762	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagaccctgaaggacttccaGtacattgaccgagatggcaa	10	11	0	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:19186762G>C	uc002gvd.3	+	3	778	c.330G>C	c.(328-330)CAG>CAC	p.Q110H	EPN2_uc002gvc.2_Missense_Mutation_p.Q110H|EPN2_uc010vyn.1_Missense_Mutation_p.Q110H|EPN2_uc010cql.1_Intron|EPN2_uc002gve.3_Missense_Mutation_p.Q110H|EPN2_uc002gvf.3_Intron|EPN2_uc010vyo.1_Intron|EPN2_uc002gvg.1_Missense_Mutation_p.Q110H|EPN2_uc010vyp.1_Missense_Mutation_p.Q110H|EPN2_uc010vyq.1_Missense_Mutation_p.Q110H|EPN2_uc002gvh.1_Missense_Mutation_p.Q110H	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	110	ENTH.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					AGGACTTCCAGTACATTGACC	0.567													0	0	0	0.004482	0	7	87										C	19186762	G	C	19186762	3	2	110	1	0	0	0	0	1	0	0	0	5186	1020	36	4	332	4	EPN2	17	19186762	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1432506	19186762	62008448	342	33854										
ULK2	9706	broad.mit.edu	37	chr17	19689285	19689285	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcgaaggaacatgtgggtaCaagtgggggctgccgcactg	16	8	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:19689285C>G	uc002gwm.3	-	21	2725	c.2216G>C	c.(2215-2217)TGT>TCT	p.C739S	ULK2_uc002gwn.2_Missense_Mutation_p.C739S	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	739					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					CATGTGGGTACAAGTGGGGGC	0.478													0	0	0	0.001984	0	7	62										G	19689285	C	G	19689285	3	3	110	1	0	0	0	0	1	0	0	0	16973	478	17	4	922	4	ULK2	17	19689285	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	502523	19689285	61505925	343	33855										
NLK	51701	broad.mit.edu	37	chr17	26449721	26449721	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcttgcaaaagggtcttccGggaattgaagatgttgtgtt	12	6	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:26449721G>A	uc010crj.2	+	2	763	c.551G>A	c.(550-552)CGG>CAG	p.R184Q	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	184	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		AGGGTCTTCCGGGAATTGAAG	0.393													0	0	0	0.00308	0	7	90										A	26449721	G	A	26449721	3	1	110	1	0	0	0	0	1	0	0	0	10466	1116	39	2	557	2	NLK	17	26449721	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6760436	26449721	54745489	344	33856										
ATAD5	79915	broad.mit.edu	37	chr17	29220310	29220310	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttactcaaaattgtttttcAgcacaaaatcacaatgaagg	5	7	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:29220310A>T	uc002hfs.1	+	21	4787	c.4441_splice	c.e21-2	p.H1481_splice		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5						response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				ATTGTTTTTCAGCACAAAATC	0.294													0	0	0	0.00361	0	61	253										T	29220310	A	T	29220310	5	4	110	1	0	0	0	0	0	0	1	0	1076	202	7	5	4521	5	ATAD5	17	29220310	Splice_Site	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	2770589	29220310	51974900	345	33857										
RAB11FIP4	84440	broad.mit.edu	37	chr17	29857477	29857477	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgcggagatagacaccgcctCgcgcgatgaggtaaccacac	12	13	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:29857477C>T	uc002hgn.1	+	14	2016	c.1787C>T	c.(1786-1788)TCG>TTG	p.S596L	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.S494L	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	596	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.|FIP-RBD.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GACACCGCCTCGCGCGATGAG	0.582													0	0	0	0.001855	0	11	146										T	29857477	C	T	29857477	3	4	110	1	0	0	0	0	1	0	0	0	12896	893	31	1	1841	1	RAB11FIP4	17	29857477	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	637167	29857477	51337733	346	33858										
CCT6B	10693	broad.mit.edu	37	chr17	33285634	33285634	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctccaataattagaacatttGaagtagtaccatctcctgtg	6	9	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:33285634G>A	uc002hig.2	-	3	375	c.281C>T	c.(280-282)TCA>TTA	p.S94L	CCT6B_uc010ctg.2_Missense_Mutation_p.S94L|CCT6B_uc010wcc.1_Intron|ZNF830_uc002hih.3_5'Flank	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	94				S -> T (in Ref. 1; BAA11347).	chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				TAGAACATTTGAAGTAGTACC	0.353													0	0	0	0.000602	0	4	62										A	33285634	G	A	33285634	3	1	110	1	0	0	0	0	1	0	0	0	2958	1294	45	1	1359	1	CCT6B	17	33285634	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3428157	33285634	47909576	347	33859										
CCR7	1236	broad.mit.edu	37	chr17	38711926	38711927	+	Frame_Shift_Del	DEL	AA	AA	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcccagtaggcccacgaaacAaatgatggagtacatgatag							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:38711926_38711927delAA	uc002huw.2	-	3	267_268	c.204_205delTT	c.(202-207)ATTTGTfs	p.I68fs		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	68_69	Helical; Name=1; (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				CCCACGAAACAAATGATGGAGT	0.495																		10	105	---	---								-	38711927	AA	-	38711926	7	5	110	1	0	1	0	1	0	0	0	0	2946	130	5	0	935	0	CCR7	17	38711926	Frame_Shift_Del	DEL	AA	TCGA-GD-A3OP-01A-21D-A21Z-08	5426292	38711926	42483284	348	33860										
KRT13	3860	broad.mit.edu	37	chr17	39659272	39659272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctcatctctgccagcacgcGggtcaggtcaatgcctgggg	13	14	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:39659272G>A	uc002hwu.1	-	4	877	c.814C>T	c.(814-816)CGC>TGC	p.R272C	KRT13_uc002hwv.1_Missense_Mutation_p.R272C|KRT13_uc002hww.2_Missense_Mutation_p.R165C|KRT13_uc010wfr.1_Missense_Mutation_p.R165C|KRT13_uc010cxo.2_Missense_Mutation_p.R272C|KRT13_uc002hwx.1_Missense_Mutation_p.R260C	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	272	Linker 12.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				GCCAGCACGCGGGTCAGGTCA	0.602													0	0	0	0.00361	0	45	701										A	39659272	G	A	39659272	3	1	110	1	0	0	0	0	1	0	0	0	8450	1116	39	2	582	2	KRT13	17	39659272	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	947346	39659272	41535938	349	33861										
KRT17	3872	broad.mit.edu	37	chr17	39777261	39777261	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctatctccaaggcctgcatgGtgcgccggagctccgagatc	12	14	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:39777261G>C	uc002hxh.2	-	5	1038	c.917C>G	c.(916-918)ACC>AGC	p.T306S	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	306	Coil 2.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				GGCCTGCATGGTGCGCCGGAG	0.602									Steatocystoma_Multiplex				0	0	0	0.00245	0	11	99										C	39777261	G	C	39777261	3	2	110	1	0	0	0	0	1	0	0	0	8454	1261	44	4	397	4	KRT17	17	39777261	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	117989	39777261	41417949	350	33862										
SLC25A39	51629	broad.mit.edu	37	chr17	42397441	42397441	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aactcataggtgctgatcatGatggcacaggagggggcagc	15	8	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:42397441G>A	uc002ign.2	-	12	1162	c.1008C>T	c.(1006-1008)ATC>ATT	p.I336I	SLC25A39_uc002igm.2_Silent_p.I328I|SLC25A39_uc002igo.2_Silent_p.I328I|SLC25A39_uc010wiw.1_Silent_p.I313I|SLC25A39_uc010czu.2_Silent_p.I204I	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	336	Solcar 3.|Helical; Name=6; (Potential).				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGCTGATCATGATGGCACAGG	0.617													0	0	0	0.007413	0	15	130										A	42397441	G	A	42397441	2	1	110	1	0	0	0	0	0	0	0	1	14503	1280	45	1		1	SLC25A39	17	42397441	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2620180	42397441	38797769	351	33863										
TOB1	10140	broad.mit.edu	37	chr17	48941203	48941206	+	Frame_Shift_Del	DEL	TGTA	TGTA	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtccactttctcccctatgTgtatacatctaaaccccgat							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:48941203_48941206delTGTA	uc002isw.2	-	1	208_211	c.173_176delTACA	c.(172-177)ATACACfs	p.I58fs	TOB1_uc010wmy.1_Frame_Shift_Del_p.I58fs|TOB1_uc010wmz.1_Frame_Shift_Del_p.I58fs|uc002isy.2_5'Flank	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	58_59					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTCCCCTATGTGTATACATCTAAA	0.417																		24	322	---	---								-	48941206	TGTA	-	48941203	7	5	110	1	0	1	0	1	0	0	0	0	16344	1696	59	0	865	0	TOB1	17	48941203	Frame_Shift_Del	DEL	TGTA	TCGA-GD-A3OP-01A-21D-A21Z-08	6543762	48941203	32254007	352	33864										
SPAG9	9043	broad.mit.edu	37	chr17	49043730	49043730	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gatcctctccaagaagttctGattctccaccttcatcacct	4	15	5	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:49043730G>A	uc002itc.2	-	30	4078	c.3869C>T	c.(3868-3870)TCA>TTA	p.S1290L	SPAG9_uc002itb.2_Missense_Mutation_p.S1276L|SPAG9_uc002itd.2_Missense_Mutation_p.S1280L|SPAG9_uc002ita.2_Missense_Mutation_p.S1146L	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1290					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AAGAAGTTCTGATTCTCCACC	0.418													0	0	0	0.003163	0	12	160										A	49043730	G	A	49043730	3	1	110	1	0	0	0	0	1	0	0	0	14985	1294	45	1	100	1	SPAG9	17	49043730	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	102527	49043730	32151480	353	33865										
NOG	9241	broad.mit.edu	37	chr17	54672146	54672146	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agcgctcgtgctccgtgcccGagggcatggtgtgcaagccg	16	13	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:54672146G>A	uc002iup.2	+	1	1087	c.562G>A	c.(562-564)GAG>AAG	p.E188K		NM_005450	NP_005441	Q13253	NOGG_HUMAN	noggin precursor	188					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity				0	Breast(9;5.24e-08)					CTCCGTGCCCGAGGGCATGGT	0.687													0	0	0	0.000602	0	3	33										A	54672146	G	A	54672146	3	1	110	1	0	0	0	0	1	0	0	0	10519	1059	37	1	564	1	NOG	17	54672146	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5628416	54672146	26523064	354	33866										
MED13	9969	broad.mit.edu	37	chr17	60032756	60032756	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tacgtaccattgttgggattGaaagctaaatccaaattttc	7	7	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:60032756G>C	uc002izo.2	-	26	6032	c.5955C>G	c.(5953-5955)TTC>TTG	p.F1985L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1985					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TGTTGGGATTGAAAGCTAAAT	0.244													0	0	0	0.008291	0	9	53										C	60032756	G	C	60032756	3	2	110	1	0	0	0	0	1	0	0	0	9430	1281	45	1	589	1	MED13	17	60032756	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5360610	60032756	21162454	355	33867										
MED13	9969	broad.mit.edu	37	chr17	60059762	60059762	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtctgctgctccaaagggtGaaaataaattagtgcactga	11	7	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:60059762G>T	uc002izo.2	-	16	3679	c.3602C>A	c.(3601-3603)TCA>TAA	p.S1201*		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1201					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCCAAAGGGTGAAAATAAATT	0.388													1	0	1.06961e-07	0.00308	1.1503e-07	8	134										T	60059762	G	T	60059762	4	4	110	1	0	0	0	0	0	1	0	0	9430	1294	45	3	2982	3	MED13	17	60059762	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	27006	60059762	21135448	356	33868										
MED13	9969	broad.mit.edu	37	chr17	60059866	60059866	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgttcagcagaggtagccctGagagcttcaaaacgtttttc	10	9	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:60059866G>T	uc002izo.2	-	16	3575	c.3498C>A	c.(3496-3498)CTC>CTA	p.L1166L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1166					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AGGTAGCCCTGAGAGCTTCAA	0.348													1	0	2.27111e-07	0.001368	2.43194e-07	13	134										T	60059866	G	T	60059866	2	4	110	1	0	0	0	0	0	0	0	1	9430	1277	45	3		3	MED13	17	60059866	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	104	60059866	21135344	357	33869										
CD300LB	124599	broad.mit.edu	37	chr17	72518922	72518922	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggttcggagaagttcatgtaGataggctgttcccctggctc	13	9	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:72518922G>C	uc002jkx.2	-	4	685	c.672C>G	c.(670-672)ATC>ATG	p.I224M		NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	187	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						AGTTCATGTAGATAGGCTGTT	0.537													0	0	0	0.000978	0	9	116										C	72518922	G	C	72518922	3	2	110	1	0	0	0	0	1	0	0	0	2999	932	33	1	48	1	CD300LB	17	72518922	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	12459056	72518922	8676288	358	33870										
TMC8	147138	broad.mit.edu	37	chr17	76136966	76136966	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acctgtcgcgactgctgccgGagccaggcccgagcgactct	13	16	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:76136966G>C	uc002jup.2	+	16	2336	c.1954G>C	c.(1954-1956)GAG>CAG	p.E652Q	TMC8_uc002juq.2_Missense_Mutation_p.E429Q	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	652	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ACTGCTGCCGGAGCCAGGCCC	0.682									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.009096	0	3	34										C	76136966	G	C	76136966	3	2	110	1	0	0	0	0	1	0	0	0	15988	1175	41	1	2012	1	TMC8	17	76136966	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	3618044	76136966	5058244	359	33871										
DNAH17	8632	broad.mit.edu	37	chr17	76548800	76548800	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttcgccattccagaataatgTcgtttcagcgctcaataact	6	11	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr17:76548800T>C	uc002jvv.1	-	11	1478	c.1372A>G	c.(1372-1374)ACA>GCA	p.T458A						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGAATAATGTCGTTTCAGCG	0.428													0	0	0	0.000978	0	11	279										C	76548800	T	C	76548800	3	2	110	1	0	0	0	0	1	0	0	0	4601	1667	58	5	11390	5	DNAH17	17	76548800	Missense_Mutation	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	411834	76548800	4646410	360	33872										
ABHD3	171586	broad.mit.edu	37	chr18	19239256	19239256	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaaaagttgcagctgccatCaaaggcgttttggacccaat	10	9	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:19239256C>T	uc002ktl.2	-	6	857	c.717G>A	c.(715-717)TTG>TTA	p.L239L	ABHD3_uc002ktm.2_Silent_p.L186L|ABHD3_uc010xao.1_RNA|ABHD3_uc002ktk.2_Silent_p.L44L|ABHD3_uc002ktn.2_Silent_p.L16L	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	239						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1						CAGCTGCCATCAAAGGCGTTT	0.393													0	0	0	0.001984	0	7	108										T	19239256	C	T	19239256	2	4	110	1	0	0	0	0	0	0	0	1	83	825	29	1		1	ABHD3	18	19239256	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		19239256	58837992	361	33873										
SLC39A6	25800	broad.mit.edu	37	chr18	33706705	33706705	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtcatggtgtatatggattCttttaatcttatctatgcct	8	6	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:33706705C>G	uc010dmy.2	-	2	556	c.266G>C	c.(265-267)AGA>ACA	p.R89T	SLC39A6_uc002kzj.2_Intron	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	89	Extracellular (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						TATATGGATTCTTTTAATCTT	0.169													0	0	0	0.009096	0	4	27										G	33706705	C	G	33706705	3	3	110	1	0	0	0	0	1	0	0	0	14622	913	32	1	2049	1	SLC39A6	18	33706705	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	14467449	33706705	44370543	362	33874										
SYT4	6860	broad.mit.edu	37	chr18	40850420	40850420	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcacccaagactaactgcccGattacctcatttcgggaccc	7	16	1	1	rs117568424	byFrequency	TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:40850420G>A	uc002law.2	-	4	1533	c.1164C>T	c.(1162-1164)ATC>ATT	p.I388I	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Silent_p.I370I|SYT4_uc010dnh.2_RNA	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	388	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CTAACTGCCCGATTACCTCAT	0.473													0	0	0	0.001168	0	6	145										A	40850420	G	A	40850420	2	1	110	1	0	0	0	0	0	0	0	1	15473	1048	37	1		1	SYT4	18	40850420	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7143715	40850420	37226828	363	33875										
ACAA2	10449	broad.mit.edu	37	chr18	47320775	47320775	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggacatgctgatctgttaatGatacccataaagaatcttcc	7	9	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:47320775G>A	uc002ldw.3	-	5	849	c.452C>T	c.(451-453)TCA>TTA	p.S151L	ACAA2_uc002ldx.3_Missense_Mutation_p.S148L	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	151					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						ATCTGTTAATGATACCCATAA	0.328													0	0	0	0.009096	0	3	44										A	47320775	G	A	47320775	3	1	110	1	0	0	0	0	1	0	0	0	105	1294	45	1	765	1	ACAA2	18	47320775	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6470355	47320775	30756473	364	33876										
ZNF407	55628	broad.mit.edu	37	chr18	72343115	72343115	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agcaagtttccctgagaattCtatgggcaaaagaggttttt	10	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:72343115C>T	uc002llw.2	+	1	197	c.140C>T	c.(139-141)TCT>TTT	p.S47F	ZNF407_uc010xfc.1_Missense_Mutation_p.S47F|ZNF407_uc010dqu.1_Missense_Mutation_p.S47F|ZNF407_uc002llu.2_Missense_Mutation_p.S46F	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CCTGAGAATTCTATGGGCAAA	0.388													0	0	0	0.004672	0	3	33										T	72343115	C	T	72343115	3	4	110	1	0	0	0	0	1	0	0	0	17884	913	32	1	142	1	ZNF407	18	72343115	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	25022340	72343115	5734133	365	33877			2	153		3	3	832	N	G_C	6.850016e-05
ZNF407	55628	broad.mit.edu	37	chr18	72343658	72343658	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccacaaagcagagagcagctCagcactacatatgcatatca	7	12	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:72343658C>T	uc002llw.2	+	1	740	c.683C>T	c.(682-684)TCA>TTA	p.S228L	ZNF407_uc010xfc.1_Missense_Mutation_p.S228L|ZNF407_uc010dqu.1_Missense_Mutation_p.S228L|ZNF407_uc002llu.2_Missense_Mutation_p.S227L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	228	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GAGAGCAGCTCAGCACTACAT	0.438													0	0	0	0.004007	0	17	151										T	72343658	C	T	72343658	3	4	110	1	0	0	0	0	1	0	0	0	17884	838	29	1	685	1	ZNF407	18	72343658	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	543	72343658	5733590	366	33878			2	153		3	3	832	N	G_C	6.850016e-05
ZNF407	55628	broad.mit.edu	37	chr18	72343946	72343946	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaaaggattacgaaatgtggGaagcacgtttaaagatttca	10	4	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr18:72343946G>A	uc002llw.2	+	1	1028	c.971G>A	c.(970-972)GGA>GAA	p.G324E	ZNF407_uc010xfc.1_Missense_Mutation_p.G324E|ZNF407_uc010dqu.1_Missense_Mutation_p.G324E|ZNF407_uc002llu.2_Missense_Mutation_p.G323E	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CGAAATGTGGGAAGCACGTTT	0.343													0	0	0	0.001368	0	10	114										A	72343946	G	A	72343946	3	1	110	1	0	0	0	0	1	0	0	0	17884	1174	41	1	973	1	ZNF407	18	72343946	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	288	72343946	5733302	367	33879			2	153		3	3	832	N	G_C	6.850016e-05
ELAVL1	1994	broad.mit.edu	37	chr19	8056716	8056716	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acattgtatttttcaaaaatCtgccaagagaaaaagagcaa	6	6	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:8056716C>G	uc002mjb.2	-	2	152	c.-15_splice	c.e2-1			NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1						3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						TTTCAAAAATCTGCCAAGAGA	0.373													0	0	0	0.001984	0	6	30										G	8056716	C	G	8056716	5	3	110	1	0	0	0	0	0	0	1	0	5049	927	32	1		1	ELAVL1	19	8056716	Splice_Site	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		8056716	51072267	368	33880										
CC2D1A	54862	broad.mit.edu	37	chr19	14028882	14028882	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtatgttgttctcccttccaGgtccctgcagccctggccct	9	16	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14028882G>A	uc002mxo.2	+	7	1048	c.749_splice	c.e7-1	p.G250_splice	CC2D1A_uc002mxn.2_Splice_Site_p.G149_splice|CC2D1A_uc002mxp.2_Splice_Site_p.G250_splice|CC2D1A_uc010dzh.2_Splice_Site|CC2D1A_uc002mxq.1_5'Flank	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A						positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CTCCCTTCCAGGTCCCTGCAG	0.517													0	0	0	0.006214	0	7	42										A	14028882	G	A	14028882	5	1	110	1	0	0	0	0	0	0	1	0	2726	1014	35	2	774	2	CC2D1A	19	14028882	Splice_Site	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5972166	14028882	45100101	369	33881										
OR7C1	26664	broad.mit.edu	37	chr19	14910386	14910386	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taatgaaggtgtcagaacagGcgagcttcaggacttcaagt	12	7	3	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14910386G>A	uc010xnz.1	-	1	563	c.563C>T	c.(562-564)GCC>GTC	p.A188V		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	188	Extracellular (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						GTCAGAACAGGCGAGCTTCAG	0.423													0	0	0	0.000978	0	8	113										A	14910386	G	A	14910386	3	1	110	1	0	0	0	0	1	0	0	0	11217	1203	42	2	401	2	OR7C1	19	14910386	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	881504	14910386	44218597	370	33882			3	154		3	3	494	G		2.416618e-05
OR7C1	26664	broad.mit.edu	37	chr19	14910475	14910475	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcaaaacagtcaaggtctcGagcagggaacccatgacact	9	12	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14910475G>C	uc010xnz.1	-	1	474	c.474C>G	c.(472-474)CTC>CTG	p.L158L		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	158	Helical; Name=4; (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						TCAAGGTCTCGAGCAGGGAAC	0.522													0	0	0	0.004482	0	8	157										C	14910475	G	C	14910475	2	2	110	1	0	0	0	0	0	0	0	1	11217	1045	37	1		1	OR7C1	19	14910475	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	89	14910475	44218508	371	33883			3	154		3	3	494	G		2.416618e-05
OR7C1	26664	broad.mit.edu	37	chr19	14910879	14910879	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cagcccaaagagaatgaactGaatctctgacgttgctgaaa	9	9	1	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14910879G>T	uc010xnz.1	-	1	70	c.70C>A	c.(70-72)CAG>AAG	p.Q24K		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	24	Extracellular (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AGAATGAACTGAATCTCTGAC	0.468													1	0	3.59834e-05	0.001168	3.78812e-05	6	159										T	14910879	G	T	14910879	3	4	110	1	0	0	0	0	1	0	0	0	11217	1299	45	3	894	3	OR7C1	19	14910879	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	404	14910879	44218104	372	33884			3	154		3	3	494	G		2.416618e-05
OR7A17	26333	broad.mit.edu	37	chr19	14992003	14992003	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aagaagtacatgggggtgtgGaggtgggagtctgagattgt	19	2	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:14992003G>C	uc010xob.1	-	1	165	c.165C>G	c.(163-165)CTC>CTG	p.L55L		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					TGGGGGTGTGGAGGTGGGAGT	0.498													0	0	0	0.00308	0	6	81										C	14992003	G	C	14992003	2	2	110	1	0	0	0	0	0	0	0	1	11215	1161	41	1		1	OR7A17	19	14992003	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	81124	14992003	44136980	373	33885										
AKAP8L	26993	broad.mit.edu	37	chr19	15508413	15508413	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttcggagctcctctgtcttCttggtcttgttagtgacgta	10	9	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:15508413C>T	uc002naw.1	-	11	1422	c.1323G>A	c.(1321-1323)AAG>AAA	p.K441K	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Silent_p.K380K	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	441						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CCTCTGTCTTCTTGGTCTTGT	0.502													0	0	0	0.001984	0	5	38										T	15508413	C	T	15508413	2	4	110	1	0	0	0	0	0	0	0	1	458	912	32	1		1	AKAP8L	19	15508413	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	516410	15508413	43620570	374	33886										
CRLF1	9244	broad.mit.edu	37	chr19	18709341	18709341	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gggcgtaaagagagccaggtCcttggggatgtggcaggagt	19	6	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:18709341C>T	uc010ebt.1	-	4	792	c.598G>A	c.(598-600)GAC>AAC	p.D200N		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	200	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						AGAGCCAGGTCCTTGGGGATG	0.622													0	0	0	0.007413	0	13	148										T	18709341	C	T	18709341	3	4	110	1	0	0	0	0	1	0	0	0	3886	855	30	1	694	1	CRLF1	19	18709341	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3200928	18709341	40419642	375	33887			4	155	3798462	3	3	316	C		9.871089e-06
CRLF1	9244	broad.mit.edu	37	chr19	18709383	18709383	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gggccccactgtgtggtactCctcacatgtgttgtcctggc	12	13	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:18709383C>T	uc010ebt.1	-	4	750	c.556G>A	c.(556-558)GAG>AAG	p.E186K		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	186	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						GTGTGGTACTCCTCACATGTG	0.632													0	0	0	0.001882	0	20	150										T	18709383	C	T	18709383	3	4	110	1	0	0	0	0	1	0	0	0	3886	864	30	1	736	1	CRLF1	19	18709383	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	42	18709383	40419600	376	33888			4	155	3798462	3	3	316	C		9.871089e-06
CRLF1	9244	broad.mit.edu	37	chr19	18709656	18709656	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctggcgtccagcggcaggtCaagtccttcatgttcttgga	12	12	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:18709656C>G	uc010ebt.1	-	3	647	c.453G>C	c.(451-453)TTG>TTC	p.L151F		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	151	Fibronectin type-III 1.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						AGCGGCAGGTCAAGTCCTTCA	0.607													0	0	0	0.000978	0	8	90										G	18709656	C	G	18709656	3	3	110	1	0	0	0	0	1	0	0	0	3886	825	29	1	843	1	CRLF1	19	18709656	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	273	18709656	40419327	377	33889			4	155	3798462	3	3	316	C		9.871089e-06
C19orf12	83636	broad.mit.edu	37	chr19	30199175	30199175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acttaccaacggcgagtcccGgtgggccgcccaccaaaccc	10	18	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:30199175G>A	uc002nsk.2	-	2	577	c.146C>T	c.(145-147)CCG>CTG	p.P49L	C19orf12_uc002nsj.2_Missense_Mutation_p.P60L|C19orf12_uc002nsl.2_Intron|C19orf12_uc002nsm.2_RNA	NM_031448	NP_113636	Q9NSK7	CS012_HUMAN	hypothetical protein LOC83636 isoform 2	49	Helical; (Potential).					integral to membrane					0	Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			GGCGAGTCCCGGTGGGCCGCC	0.572													0	0	0	0.002836	0	23	106										A	30199175	G	A	30199175	3	1	110	1	0	0	0	0	1	0	0	0	1909	1116	39	2	287	2	C19orf12	19	30199175	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	11489519	30199175	28929808	378	33890										
RGS9BP	388531	broad.mit.edu	37	chr19	33167295	33167295	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctgcggcaggagctgcaaaaGacgcgccagaaggcgcagga	16	11	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:33167295G>C	uc002ntp.1	+	1	983	c.126G>C	c.(124-126)AAG>AAC	p.K42N	ANKRD27_uc002ntn.1_5'Flank|ANKRD27_uc002nto.1_5'Flank	NM_207391	NP_997274	Q6ZS82	R9BP_HUMAN	RGS9 anchor protein	42	Potential.|Cytoplasmic (Potential).				negative regulation of signal transduction	integral to membrane				central_nervous_system(1)	1	Esophageal squamous(110;0.137)					AGCTGCAAAAGACGCGCCAGA	0.701													0	0	0	0.004672	0	3	27										C	33167295	G	C	33167295	3	2	110	1	0	0	0	0	1	0	0	0	13314	933	33	1	128	1	RGS9BP	19	33167295	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2968120	33167295	25961688	379	33891										
ZFP30	22835	broad.mit.edu	37	chr19	38126715	38126715	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttcccacattctttacattCatacggcttctcaccaatat	2	13	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:38126715C>T	uc002ogv.1	-	6	1243	c.727G>A	c.(727-729)GAA>AAA	p.E243K	ZFP30_uc002ogw.1_Missense_Mutation_p.E243K|ZFP30_uc002ogx.1_Missense_Mutation_p.E243K|ZFP30_uc010xtt.1_Missense_Mutation_p.E242K	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	243	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTTTACATTCATACGGCTTC	0.388													0	0	0	0.010504	0	19	52										T	38126715	C	T	38126715	3	4	110	1	0	0	0	0	1	0	0	0	17641	835	29	1	836	1	ZFP30	19	38126715	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4959420	38126715	21002268	380	33892										
KCNK6	9424	broad.mit.edu	37	chr19	38817601	38817601	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggcccctggccagccctacCgggccctctacaaggtgctg	12	17	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:38817601C>T	uc002oic.2	+	2	801	c.691C>T	c.(691-693)CGG>TGG	p.R231W	KCNK6_uc002oid.2_Missense_Mutation_p.R97W	NM_004823	NP_004814	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	231						voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)	1	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	CCAGCCCTACCGGGCCCTCTA	0.627													0	0	0	0.00499	0	16	125										T	38817601	C	T	38817601	3	4	110	1	0	0	0	0	1	0	0	0	8070	643	23	2	697	2	KCNK6	19	38817601	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	690886	38817601	20311382	381	33893										
PLEKHG2	64857	broad.mit.edu	37	chr19	39915786	39915786	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcggctcagctatgccacgaCggttaacatccacgtgggcg	13	13	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:39915786C>T	uc010xuz.1	+	19	4338	c.4013C>T	c.(4012-4014)ACG>ATG	p.T1338M	PLEKHG2_uc010xuy.1_Intron|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.T1116M	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	1338					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TATGCCACGACGGTTAACATC	0.692													0	0	0	0.000602	0	4	40										T	39915786	C	T	39915786	3	4	110	1	0	0	0	0	1	0	0	0	12069	536	19	2	4083	2	PLEKHG2	19	39915786	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1098185	39915786	19213197	382	33894										
ATP1A3	478	broad.mit.edu	37	chr19	42490310	42490310	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gactccatgatcttggagctCttggcctcctggtagtagga	12	10	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:42490310C>T	uc002osg.2	-	5	583	c.429G>A	c.(427-429)AAG>AAA	p.K143K	ATP1A3_uc010xwf.1_Silent_p.K154K|ATP1A3_uc010xwg.1_Silent_p.K113K|ATP1A3_uc010xwh.1_Silent_p.K156K|ATP1A3_uc002osh.2_Silent_p.K143K	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	143	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TCTTGGAGCTCTTGGCCTCCT	0.607													0	0	0	0.006122	0	15	155										T	42490310	C	T	42490310	2	4	110	1	0	0	0	0	0	0	0	1	1130	912	32	1		1	ATP1A3	19	42490310	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2574524	42490310	16638673	383	33895										
PSG8	440533	broad.mit.edu	37	chr19	43259327	43259327	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	caccaaatgtaggtgtagttCtcactcttaggttcacaggt	9	9	3	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:43259327C>A	uc002ouo.2	-	4	899	c.801G>T	c.(799-801)GAG>GAT	p.E267D	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_Intron|PSG8_uc002oui.2_Missense_Mutation_p.E106D|PSG8_uc002ouh.2_Missense_Mutation_p.E267D|PSG8_uc010ein.2_Missense_Mutation_p.E145D|PSG8_uc002ouj.3_Missense_Mutation_p.E49D|PSG8_uc002ouk.3_Missense_Mutation_p.E106D|PSG8_uc002oul.3_Missense_Mutation_p.E267D|PSG8_uc002oum.3_Missense_Mutation_p.E174D|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.E174D	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	267	Ig-like C2-type 2.					extracellular region					0		Prostate(69;0.00899)				AGGTGTAGTTCTCACTCTTAG	0.483													1	0	4.59853e-10	0.005443	5.02115e-10	17	253										A	43259327	C	A	43259327	3	1	110	1	0	0	0	0	1	0	0	0	12661	912	32	3	508	3	PSG8	19	43259327	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	769017	43259327	15869656	384	33896										
ZNF285	26974	broad.mit.edu	37	chr19	44891132	44891132	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcaccacacctatatggtttCtcccctgtgtgaaacctcca	5	15	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:44891132C>T	uc002ozd.3	-	4	1362	c.1275G>A	c.(1273-1275)GAG>GAA	p.E425E	ZFP112_uc010xwz.1_Intron|ZNF285_uc010xxa.1_Silent_p.E432E	NM_152354	NP_689567	Q96NJ3	ZN285_HUMAN	zinc finger protein 285	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(2)	4						TATATGGTTTCTCCCCTGTGT	0.493													0	0	0	0.006214	0	8	67										T	44891132	C	T	44891132	2	4	110	1	0	0	0	0	0	0	0	1	17819	912	32	1		1	ZNF285	19	44891132	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	1631805	44891132	14237851	385	33897										
SFRS16	11129	broad.mit.edu	37	chr19	45563675	45563675	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggaaagacaaggaggaggcaGaggccatcaagcatgccaag	15	8	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:45563675G>A	uc002pak.2	+	9	837	c.739G>A	c.(739-741)GAG>AAG	p.E247K	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Missense_Mutation_p.E185K|SFRS16_uc002pam.2_Missense_Mutation_p.E247K|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	247					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGAGGAGGCAGAGGCCATCAA	0.587													0	0	0	0.008291	0	8	105										A	45563675	G	A	45563675	3	1	110	1	0	0	0	0	1	0	0	0	14172	943	33	1	769	1	SFRS16	19	45563675	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	672543	45563675	13565308	386	33898										
PPFIA3	8541	broad.mit.edu	37	chr19	49643260	49643260	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacaaagcccccaagaagaaGagcatcaagtcatccatagg	8	12	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:49643260G>A	uc002pmr.2	+	18	2615	c.2283G>A	c.(2281-2283)AAG>AAA	p.K761K	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Silent_p.K629K|PPFIA3_uc002pmt.2_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	761						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CCAAGAAGAAGAGCATCAAGT	0.557													0	0	0	0.004482	0	8	161										A	49643260	G	A	49643260	2	1	110	1	0	0	0	0	0	0	0	1	12311	933	33	1		1	PPFIA3	19	49643260	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4079585	49643260	9485723	387	33899										
DKKL1	27120	broad.mit.edu	37	chr19	49867919	49867919	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggtgatcccctccgctgcaGctcctatccatgatgctgac	9	15	0	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:49867919G>A	uc002pnk.2	+	2	305	c.91G>A	c.(91-93)GCT>ACT	p.A31T	TEAD2_uc002pni.2_5'Flank|TEAD2_uc002pnj.2_5'Flank|TEAD2_uc010yao.1_5'Flank|TEAD2_uc010emw.2_5'Flank	NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	31					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		CTCCGCTGCAGCTCCTATCCA	0.622													0	0	0	0.008291	0	8	89										A	49867919	G	A	49867919	3	1	110	1	0	0	0	0	1	0	0	0	4548	971	34	2	97	2	DKKL1	19	49867919	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	224659	49867919	9261064	388	33900										
VRK3	51231	broad.mit.edu	37	chr19	50510925	50510925	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgtccctgtgggcaaagcttCaagtgaggtggtcactcggc	14	10	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:50510925C>T	uc002prg.2	-	5	546	c.448G>A	c.(448-450)GAA>AAA	p.E150K	VRK3_uc002prh.1_Missense_Mutation_p.E150K|VRK3_uc002pri.1_Missense_Mutation_p.E100K|VRK3_uc010ens.2_Missense_Mutation_p.E150K|VRK3_uc010ybl.1_Missense_Mutation_p.E100K|VRK3_uc010ybm.1_5'UTR|VRK3_uc002prj.1_Missense_Mutation_p.E100K|VRK3_uc002prk.1_Missense_Mutation_p.E150K|VRK3_uc010ent.1_5'UTR|VRK3_uc002prl.2_Missense_Mutation_p.E150K|VRK3_uc010ybn.1_Missense_Mutation_p.E150K	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	150						nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GGCAAAGCTTCAAGTGAGGTG	0.582													0	0	0	0.00308	0	7	152										T	50510925	C	T	50510925	3	4	110	1	0	0	0	0	1	0	0	0	17218	835	29	1	1016	1	VRK3	19	50510925	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	643006	50510925	8618058	389	33901										
C19orf41	126123	broad.mit.edu	37	chr19	50666221	50666221	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aatttctcccaacacgcaccCactttccccacaaacacgtt	2	18	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:50666221C>A	uc002prp.1	-	1	318	c.231G>T	c.(229-231)GTG>GTT	p.V77V		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	77	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		AACACGCACCCACTTTCCCCA	0.682													1	0	0.000157383	0.00308	0.000163955	5	69										A	50666221	C	A	50666221	2	1	110	1	0	0	0	0	0	0	0	1	1924	608	21	4		4	C19orf41	19	50666221	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	155296	50666221	8462762	390	33902										
ZNF347	84671	broad.mit.edu	37	chr19	53644299	53644299	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcattacatttataaggtttCtctccagtatgaattccccg	5	10	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:53644299C>T	uc002qbb.1	-	5	1851	c.1782G>A	c.(1780-1782)GAG>GAA	p.E594E	ZNF347_uc010eql.1_Silent_p.E595E|ZNF347_uc002qbc.1_Silent_p.E595E	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TATAAGGTTTCTCTCCAGTAT	0.388													0	0	0	0.010504	0	17	151										T	53644299	C	T	53644299	2	4	110	1	0	0	0	0	0	0	0	1	17858	912	32	1		1	ZNF347	19	53644299	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2978078	53644299	5484684	391	33903										
PRKCG	5582	broad.mit.edu	37	chr19	54410095	54410095	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acctacgtgaaccccgacttCgtgcacccggatgcccgcag	10	17	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:54410095C>A	uc002qcq.1	+	18	2322	c.2040C>A	c.(2038-2040)TTC>TTA	p.F680L	PRKCG_uc010yeg.1_Missense_Mutation_p.F680L|PRKCG_uc010yeh.1_Missense_Mutation_p.F531L	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	680	AGC-kinase C-terminal.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACCCCGACTTCGTGCACCCGG	0.687											OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.80697e-09	0.000978	3.05159e-09	10	139										A	54410095	C	A	54410095	3	1	110	1	0	0	0	0	1	0	0	0	12512	883	31	3	2110	3	PRKCG	19	54410095	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	765796	54410095	4718888	392	33904										
ZNF582	147948	broad.mit.edu	37	chr19	56896256	56896256	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccttttgccagaagtcttttCtacatttattatacccaaaa	3	10	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:56896256C>G	uc002qmz.1	-	5	689	c.530G>C	c.(529-531)AGA>ACA	p.R177T	ZNF582_uc002qmy.2_Missense_Mutation_p.R208T	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	177	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		GAAGTCTTTTCTACATTTATT	0.328													0	0	0	0.004672	0	3	41										G	56896256	C	G	56896256	3	3	110	1	0	0	0	0	1	0	0	0	18011	913	32	1	1027	1	ZNF582	19	56896256	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	2486161	56896256	2232727	393	33905										
SLC27A5	10998	broad.mit.edu	37	chr19	59022230	59022230	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtgtaggggaggtatggctGaggtagaagcagcggatgtt	20	3	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr19:59022230G>A	uc002qtc.2	-	2	866	c.756C>T	c.(754-756)CTC>CTT	p.L252L		NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	252	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		AGGTATGGCTGAGGTAGAAGC	0.632													0	0	0	0.004672	0	3	37										A	59022230	G	A	59022230	2	1	110	1	0	0	0	0	0	0	0	1	14529	1277	45	1		1	SLC27A5	19	59022230	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2125974	59022230	106753	394	33906										
SNRPB	6628	broad.mit.edu	37	chr20	2443773	2443773	+	Frame_Shift_Del	DEL	C	C	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggcccataggtgggggaggaCccccacggccaggtgggtac							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:2443773delC	uc002wfz.1	-	5	684	c.521delG	c.(520-522)GGTfs	p.G174fs	SNRPB_uc002wga.1_Frame_Shift_Del_p.G174fs|SNRPB_uc010zpv.1_Frame_Shift_Del_p.G95fs|SNRPB_uc002wgb.2_Frame_Shift_Del_p.G174fs|SNORD119_uc010gam.1_5'Flank	NM_198216	NP_937859	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptide B/B'	174					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|protein binding|RNA binding			ovary(1)	1						TGGGGGAGGACCCCCACGGCC	0.592																		12	252	---	---								-	2443773	C	-	2443773	7	5	110	1	0	1	0	1	0	0	0	0	14861	507	18	0	228	0	SNRPB	20	2443773	Frame_Shift_Del	DEL	C	TCGA-GD-A3OP-01A-21D-A21Z-08		2443773	60581747	395	33907										
FASTKD5	60493	broad.mit.edu	37	chr20	3128235	3128235	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aacctgacaaaccctggactGagagcgaaatcaattaactc	7	11	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:3128235G>C	uc002whz.2	-	2	1793	c.1482C>G	c.(1480-1482)CTC>CTG	p.L494L	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	494					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						ACCCTGGACTGAGAGCGAAAT	0.473													0	0	0	0.001168	0	6	74										C	3128235	G	C	3128235	2	2	110	1	0	0	0	0	0	0	0	1	5688	1277	45	1		1	FASTKD5	20	3128235	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	684462	3128235	59897285	396	33908										
ATRN	8455	broad.mit.edu	37	chr20	3562848	3562848	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgtcctactggtgctgggaaGatatgtccccatttacaaat	9	9	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:3562848G>A	uc002wim.2	+	16	2701	c.2611G>A	c.(2611-2613)GAT>AAT	p.D871N	ATRN_uc002wil.2_Missense_Mutation_p.D871N	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	871	Extracellular (Potential).|C-type lectin.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GTGCTGGGAAGATATGTCCCC	0.468													0	0	0	0.00245	0	12	94										A	3562848	G	A	3562848	3	1	110	1	0	0	0	0	1	0	0	0	1206	942	33	1	2673	1	ATRN	20	3562848	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	434613	3562848	59462672	397	33909										
ATRN	8455	broad.mit.edu	37	chr20	3562949	3562949	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaacccagtactcggggactGaaggctgcaacctgcatcaa	11	12	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:3562949G>A	uc002wim.2	+	16	2802	c.2712G>A	c.(2710-2712)CTG>CTA	p.L904L	ATRN_uc002wil.2_Silent_p.L904L	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	904	Extracellular (Potential).|C-type lectin.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CTCGGGGACTGAAGGCTGCAA	0.453													0	0	0	0.006214	0	10	176										A	3562949	G	A	3562949	2	1	110	1	0	0	0	0	0	0	0	1	1206	1277	45	1		1	ATRN	20	3562949	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	101	3562949	59462571	398	33910										
ABHD12	26090	broad.mit.edu	37	chr20	25275652	25275652	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tgggatctgggctggaacctGggccctgctgaggtctgtga	17	9	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:25275652G>A	uc002wuq.2	-	13	1310	c.1172C>T	c.(1171-1173)CCA>CTA	p.P391L	ABHD12_uc002wur.2_Missense_Mutation_p.P390L|PYGB_uc002wup.2_Intron	NM_015600	NP_056415	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform b	Error:Variant_position_missing_in_Q8N2K0_after_alignment						integral to membrane	acylglycerol lipase activity			skin(1)	1						GCTGGAACCTGGGCCCTGCTG	0.473											OREG0025844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	9	211										A	25275652	G	A	25275652	3	1	110	1	0	0	0	0	1	0	0	0	76	1348	47	2	46	2	ABHD12	20	25275652	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	21712703	25275652	37749868	399	33911										
PIGU	128869	broad.mit.edu	37	chr20	33222438	33222438	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccttttatcgtagtcaaaatGaagaaagcaatgagggtgtt	10	5	1	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:33222438G>C	uc002xas.2	-	6	710	c.510C>G	c.(508-510)TTC>TTG	p.F170L	PIGU_uc010zul.1_Missense_Mutation_p.F170L|PIGU_uc002xat.2_Missense_Mutation_p.F150L|PIGU_uc010gev.1_RNA	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	170	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0						TAGTCAAAATGAAGAAAGCAA	0.403													0	0	0	0.008291	0	7	91										C	33222438	G	C	33222438	3	2	110	1	0	0	0	0	1	0	0	0	11900	1281	45	1	825	1	PIGU	20	33222438	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7946786	33222438	29803082	400	33912										
NCOA6	23054	broad.mit.edu	37	chr20	33356291	33356291	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	accacttgccataggaaatcCcgcctccatcctaactgaat	5	15	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:33356291C>A	uc002xav.2	-	6	3061	c.490G>T	c.(490-492)GGA>TGA	p.G164*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.G164*|NCOA6_uc010gew.1_Nonsense_Mutation_p.G164*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	164	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						ATAGGAAATCCCGCCTCCATC	0.458													1	0	3.52763e-06	0.00499	3.7613e-06	14	125										A	33356291	C	A	33356291	4	1	110	1	0	0	0	0	0	1	0	0	10233	632	22	4	5745	4	NCOA6	20	33356291	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	133853	33356291	29669229	401	33913										
SRC	6714	broad.mit.edu	37	chr20	36022668	36022668	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccttcctcgtgcgagaaagtGagaccacgaaaggtacgagc	12	11	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:36022668G>A	uc002xgx.2	+	7	990	c.541G>A	c.(541-543)GAG>AAG	p.E181K	SRC_uc002xgy.2_Missense_Mutation_p.E181K	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	181	SH2.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GCGAGAAAGTGAGACCACGAA	0.448													0	0	0	0.006214	0	8	85										A	36022668	G	A	36022668	3	1	110	1	0	0	0	0	1	0	0	0	15133	1291	45	1	555	1	SRC	20	36022668	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2666377	36022668	27002852	402	33914										
L3MBTL	26013	broad.mit.edu	37	chr20	42161536	42161536	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gccgcttcctggtgcactttGacaactgggatgatacttat	10	10	0	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:42161536G>C	uc010zwh.1	+	12	1388	c.1342G>C	c.(1342-1344)GAC>CAC	p.D448H	L3MBTL_uc002xkl.2_Missense_Mutation_p.D380H|L3MBTL_uc002xkm.2_Missense_Mutation_p.D380H|L3MBTL_uc010ggl.2_Missense_Mutation_p.D380H|L3MBTL_uc002xkn.1_Missense_Mutation_p.D139H|L3MBTL_uc002xko.2_Missense_Mutation_p.D32H	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	380	MBT 2.|Interaction with monomethylated and dimethylated peptides.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GGTGCACTTTGACAACTGGGA	0.582													0	0	0	0.004482	0	9	93										C	42161536	G	C	42161536	3	2	110	1	0	0	0	0	1	0	0	0	8591	1290	45	1	1172	1	L3MBTL	20	42161536	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6138868	42161536	20863984	403	33915										
L3MBTL	26013	broad.mit.edu	37	chr20	42162962	42162962	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctggtcaatatgaagctggaGgctgtggaccgcaggaaccc	14	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:42162962G>A	uc010zwh.1	+	15	1618	c.1572G>A	c.(1570-1572)GAG>GAA	p.E524E	L3MBTL_uc002xkl.2_Silent_p.E456E|L3MBTL_uc002xkm.2_Silent_p.E456E|L3MBTL_uc010ggl.2_Silent_p.E456E|L3MBTL_uc002xkn.1_Silent_p.E215E|L3MBTL_uc002xko.2_Silent_p.E108E	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	456	MBT 3.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGAAGCTGGAGGCTGTGGACC	0.632													0	0	0	0.004482	0	6	101										A	42162962	G	A	42162962	2	1	110	1	0	0	0	0	0	0	0	1	8591	991	35	2		2	L3MBTL	20	42162962	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1426	42162962	20862558	404	33916										
NCOA3	8202	broad.mit.edu	37	chr20	46255875	46255875	+	Missense_Mutation	SNP	G	G	A													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gtgtttacaatatcttacatGaagaagacagaaaggatttt							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:46255875G>A	uc002xtk.2	+	6	692	c.487G>A	c.(487-489)GAA>AAA	p.E163K	NCOA3_uc010ght.1_Missense_Mutation_p.E163K|NCOA3_uc002xtl.2_Missense_Mutation_p.E163K|NCOA3_uc002xtm.2_Missense_Mutation_p.E163K|NCOA3_uc002xtn.2_Missense_Mutation_p.E163K|NCOA3_uc010zyc.1_5'UTR	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	163	PAS.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TATCTTACATGAAGAAGACAG	0.313													0	0	0	0.001168	0	4	67										A	46255875	G	A	46255875	3	1	110	1	0	0	0	0	1	0	0	0	10230	1291	45	1	501	1	NCOA3	20	46255875	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	4092913	46255875	16769645	405	33917	174	2								
NCOA3	8202	broad.mit.edu	37	chr20	46255881	46255881	+	Missense_Mutation	SNP	G	G	A													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acaatatcttacatgaagaaGacagaaaggattttcttaag							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:46255881G>A	uc002xtk.2	+	6	698	c.493G>A	c.(493-495)GAC>AAC	p.D165N	NCOA3_uc010ght.1_Missense_Mutation_p.D165N|NCOA3_uc002xtl.2_Missense_Mutation_p.D165N|NCOA3_uc002xtm.2_Missense_Mutation_p.D165N|NCOA3_uc002xtn.2_Missense_Mutation_p.D165N|NCOA3_uc010zyc.1_5'UTR	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	165	PAS.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						ACATGAAGAAGACAGAAAGGA	0.308													0	0	0	0.009096	0	4	63										A	46255881	G	A	46255881	3	1	110	1	0	0	0	0	1	0	0	0	10230	942	33	1	507	1	NCOA3	20	46255881	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	6	46255881	16769639	406	33918	174	2								
CSE1L	1434	broad.mit.edu	37	chr20	47706239	47706239	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggcttcttcaagcattcttaGaacgcggttcaaacacaata	7	10	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:47706239G>A	uc002xty.2	+	19	2271	c.2137G>A	c.(2137-2139)GAA>AAA	p.E713K	CSE1L_uc010zyg.1_Missense_Mutation_p.E496K|CSE1L_uc010ghx.2_Missense_Mutation_p.E657K|CSE1L_uc010ghy.2_Missense_Mutation_p.E334K|CSE1L_uc010zyh.1_Missense_Mutation_p.E362K	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	713					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			AGCATTCTTAGAACGCGGTTC	0.418													0	0	0	0.006214	0	7	108										A	47706239	G	A	47706239	3	1	110	1	0	0	0	0	1	0	0	0	3930	943	33	1	2207	1	CSE1L	20	47706239	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	1450358	47706239	15319281	407	33919										
STAU1	6780	broad.mit.edu	37	chr20	47734330	47734330	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ttacctggaatccctggactCtggaaagatagtccagttgc	10	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:47734330C>T	uc002xud.2	-	11	1904	c.1493G>A	c.(1492-1494)AGA>AAA	p.R498K	STAU1_uc002xua.2_Missense_Mutation_p.R417K|STAU1_uc002xub.2_Missense_Mutation_p.R423K|STAU1_uc002xuc.2_Missense_Mutation_p.R417K|STAU1_uc002xue.2_Missense_Mutation_p.R417K|STAU1_uc002xuf.2_Missense_Mutation_p.R423K|STAU1_uc002xug.2_Missense_Mutation_p.R498K	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	498						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TCCCTGGACTCTGGAAAGATA	0.498													0	0	0	0.006214	0	9	68										T	47734330	C	T	47734330	3	4	110	1	0	0	0	0	1	0	0	0	15271	913	32	1	256	1	STAU1	20	47734330	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	28091	47734330	15291190	408	33920										
APCDD1L	164284	broad.mit.edu	37	chr20	57042196	57042196	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcgggcgctggtagcccgtgGgccggtagtgccgcctctcc	17	15	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr20:57042196G>T	uc002xze.1	-	3	893	c.707C>A	c.(706-708)CCC>CAC	p.P236H	APCDD1L_uc010zzp.1_Missense_Mutation_p.P247H	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	236						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			GTAGCCCGTGGGCCGGTAGTG	0.731													1	0	3.32936e-07	0.006122	3.5575e-07	14	81										T	57042196	G	T	57042196	3	4	110	1	0	0	0	0	1	0	0	0	766	1232	43	4	806	4	APCDD1L	20	57042196	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9307866	57042196	5983324	409	33921										
TIAM1	7074	broad.mit.edu	37	chr21	32617916	32617916	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccacccagacggcgtgtttgGggatgctgttgtggtctatc	14	10	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr21:32617916G>T	uc002yow.1	-	7	1944	c.1472C>A	c.(1471-1473)CCC>CAC	p.P491H	TIAM1_uc011adk.1_Missense_Mutation_p.P491H|TIAM1_uc011adl.1_Missense_Mutation_p.P491H|TIAM1_uc002yox.1_Missense_Mutation_p.P99H	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	491	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GGCGTGTTTGGGGATGCTGTT	0.552													1	0	4.096e-09	0.001168	4.44327e-09	5	56										T	32617916	G	T	32617916	3	4	110	1	0	0	0	0	1	0	0	0	15887	1232	43	4	3395	4	TIAM1	21	32617916	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08		32617916	15511979	410	33922										
UMODL1	89766	broad.mit.edu	37	chr21	43496222	43496222	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cacgtcctatgtgtcctgcgGcggctggatcccctggaggc	14	14	0	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr21:43496222G>A	uc002zaf.1	+	2	185	c.185G>A	c.(184-186)GGC>GAC	p.G62D	UMODL1_uc002zad.1_5'UTR|UMODL1_uc002zae.1_5'UTR|UMODL1_uc002zag.1_Missense_Mutation_p.G62D|uc002zah.1_RNA	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	62	Extracellular (Potential).|EMI.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GTGTCCTGCGGCGGCTGGATC	0.607													0	0	0	0.001168	0	5	77										A	43496222	G	A	43496222	3	1	110	1	0	0	0	0	1	0	0	0	16977	1203	42	2	191	2	UMODL1	21	43496222	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	10878306	43496222	4633673	411	33923										
ABCG1	9619	broad.mit.edu	37	chr21	43691217	43691217	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaaggaatttccgggaagttCaatagtggtgagttggtggc	15	4	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr21:43691217C>G	uc002zaq.2	+	3	430	c.324C>G	c.(322-324)TTC>TTG	p.F108L	ABCG1_uc002zan.2_Missense_Mutation_p.F110L|ABCG1_uc002zam.2_Missense_Mutation_p.F86L|ABCG1_uc002zao.2_Missense_Mutation_p.F105L|ABCG1_uc002zap.2_Missense_Mutation_p.F108L|ABCG1_uc002zar.2_Missense_Mutation_p.F119L|ABCG1_uc011aev.1_Missense_Mutation_p.F119L	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	108	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CCGGGAAGTTCAATAGTGGTG	0.473													0	0	0	0.003163	0	12	125										G	43691217	C	G	43691217	3	3	110	1	0	0	0	0	1	0	0	0	68	825	29	1	502	1	ABCG1	21	43691217	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	194995	43691217	4438678	412	33924										
DGCR8	54487	broad.mit.edu	37	chr22	20082278	20082279	+	Frame_Shift_Del	DEL	AG	AG	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	catccctgactttgttaaacAgacctctgaagagaagccca							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:20082278_20082279delAG	uc002zri.2	+	9	2098_2099	c.1748_1749delAG	c.(1747-1749)CAGfs	p.Q583fs	DGCR8_uc010grz.2_Frame_Shift_Del_p.Q550fs|DGCR8_uc002zrj.2_Frame_Shift_Del_p.Q226fs	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	583	Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TTTGTTAAACAGACCTCTGAAG	0.55																		13	184	---	---								-	20082279	AG	-	20082278	7	5	110	1	0	1	0	1	0	0	0	0	4464	188	7	0	1778	0	DGCR8	22	20082278	Frame_Shift_Del	DEL	AG	TCGA-GD-A3OP-01A-21D-A21Z-08		20082278	31222288	413	33925										
CRYBB3	1417	broad.mit.edu	37	chr22	25599847	25599847	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agtgacagccttctgtccctCcggcctctgaatattgtgag	10	12	2	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:25599847C>G	uc003abo.1	+	4	384	c.312C>G	c.(310-312)CTC>CTG	p.L104L		NM_004076	NP_004067	P26998	CRBB3_HUMAN	crystallin, beta B3	104	Beta/gamma crystallin 'Greek key' 2.				visual perception		protein binding|structural constituent of eye lens				0						TTCTGTCCCTCCGGCCTCTGA	0.582													0	0	0	0.002836	0	27	260										G	25599847	C	G	25599847	2	3	110	1	0	0	0	0	0	0	0	1	3912	842	30	1		1	CRYBB3	22	25599847	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5517569	25599847	25704719	414	33926										
PLA2G3	50487	broad.mit.edu	37	chr22	31533774	31533774	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gggagagaccatagggtcctGgagggctgtggtgttggctt	19	6	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:31533774G>A	uc003aka.2	-	4	1117	c.988C>T	c.(988-990)CAG>TAG	p.Q330*		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	330					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						ATAGGGTCCTGGAGGGCTGTG	0.627													0	0	0	0.003163	0	12	176										A	31533774	G	A	31533774	4	1	110	1	0	0	0	0	0	1	0	0	12000	1357	47	2	557	2	PLA2G3	22	31533774	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5933927	31533774	19770792	415	33927										
MYH9	4627	broad.mit.edu	37	chr22	36712697	36712697	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	taggtcgccttggccaaggcCtcgatggcaaagtcagcctg	13	12	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:36712697C>T	uc003apg.2	-	12	1476	c.1245G>A	c.(1243-1245)GAG>GAA	p.E415E	MYH9_uc003aph.1_Silent_p.E279E	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	415	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGCCAAGGCCTCGATGGCAA	0.478			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.001168	0	5	59										T	36712697	C	T	36712697	2	4	110	1	0	0	0	0	0	0	0	1	10042	680	24	2		2	MYH9	22	36712697	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	5178923	36712697	14591869	416	33928										
ADSL	158	broad.mit.edu	37	chr22	40755278	40755278	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tccaaggtagagcagcttgaCaagatggtgacagaaaaggc	13	7	0	5			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:40755278C>G	uc003ayp.3	+	6	728	c.669C>G	c.(667-669)GAC>GAG	p.D223E	ADSL_uc003ays.3_Missense_Mutation_p.D223E|ADSL_uc003ayq.3_Missense_Mutation_p.D223E|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Missense_Mutation_p.D208E|ADSL_uc010gyb.1_RNA	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	223					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						AGCAGCTTGACAAGATGGTGA	0.443													0	0	0	0.00499	0	13	186										G	40755278	C	G	40755278	3	3	110	1	0	0	0	0	1	0	0	0	346	477	17	4	691	4	ADSL	22	40755278	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4042581	40755278	10549288	417	33929										
SCUBE1	80274	broad.mit.edu	37	chr22	43619192	43619192	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acagctgggcccggggggagGtcttggcgcgagaaagacac	18	10	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chr22:43619192G>A	uc003bdt.1	-	11	1326	c.1238C>T	c.(1237-1239)ACC>ATC	p.T413I		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	413					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CCGGGGGGAGGTCTTGGCGCG	0.642													0	0	0	0.008871	0	15	205										A	43619192	G	A	43619192	3	1	110	1	0	0	0	0	1	0	0	0	13944	1261	44	2	1776	2	SCUBE1	22	43619192	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2863914	43619192	7685374	418	33930										
FRMPD4	9758	broad.mit.edu	37	chrX	12724949	12724949	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcttttctctcctcagctctCtgcactacaagccaaggtcc	5	16	4	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:12724949C>G	uc004cuz.1	+	12	1708	c.1202C>G	c.(1201-1203)TCT>TGT	p.S401C	FRMPD4_uc011mij.1_Missense_Mutation_p.S393C	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	401	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCTCAGCTCTCTGCACTACAA	0.428													0	0	0	0.004007	0	10	138										G	12724949	C	G	12724949	3	3	110	1	0	0	0	0	1	0	0	0	6059	913	32	1	1248	1	FRMPD4	23	12724949	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08		12724949	142545611	419	33931										
ZRSR2	8233	broad.mit.edu	37	chrX	15818001	15818001	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttaaattccctaggactctCacagaaggaggaagaggagg	12	7	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:15818001C>G	uc004cxg.3	+	3	173	c.128C>G	c.(127-129)TCA>TGA	p.S43*		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	43					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					CTAGGACTCTCACAGAAGGAG	0.328													0	0	0	0.000602	0	5	66										G	15818001	C	G	15818001	4	3	110	1	0	0	0	0	0	1	0	0	18222	838	29	1	138	1	ZRSR2	23	15818001	Nonsense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	3093052	15818001	139452559	420	33932										
CTPS2	56474	broad.mit.edu	37	chrX	16707722	16707722	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaaacatcatggatacatatGacctaagtggcgatgagaaa	10	6	1	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:16707722G>A	uc004cxk.2	-	8	1467	c.723C>T	c.(721-723)GTC>GTT	p.V241V	CTPS2_uc004cxl.2_Silent_p.V241V|CTPS2_uc004cxm.2_Silent_p.V241V	NM_001144002	NP_001137474	Q9NRF8	PYRG2_HUMAN	cytidine triphosphate synthase II	241					glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)					GGATACATATGACCTAAGTGG	0.388													0	0	0	0.004482	0	8	123										A	16707722	G	A	16707722	2	1	110	1	0	0	0	0	0	0	0	1	4023	1277	45	1		1	CTPS2	23	16707722	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	889721	16707722	138562838	421	33933										
PPEF1	5475	broad.mit.edu	37	chrX	18822166	18822166	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtctcatgaatgtaagcccGaagggtatgaaatctgtcat	11	7	3	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:18822166G>A	uc004cyq.2	+	14	1703	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K	PPEF1_uc004cyp.2_Missense_Mutation_p.E380K|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Missense_Mutation_p.E408K|PPEF1_uc011mja.1_Missense_Mutation_p.E343K|PPEF1_uc011mjb.1_Missense_Mutation_p.E352K	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	408	Catalytic.				detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					ATGTAAGCCCGAAGGGTATGA	0.433													0	0	0	0.000978	0	8	99										A	18822166	G	A	18822166	3	1	110	1	0	0	0	0	1	0	0	0	12307	1059	37	1	1264	1	PPEF1	23	18822166	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	2114444	18822166	136448394	422	33934										
SH3KBP1	30011	broad.mit.edu	37	chrX	19764521	19764521	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aggggcttttctggagctttGttggtgagagggtctttctt	15	5	3	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:19764521G>A	uc004czm.2	-	3	517	c.201C>T	c.(199-201)AAC>AAT	p.N67N	SH3KBP1_uc004czl.2_Silent_p.N30N	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	67					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						CTGGAGCTTTGTTGGTGAGAG	0.398													0	0	0	0.008871	0	16	139										A	19764521	G	A	19764521	2	1	110	1	0	0	0	0	0	0	0	1	14255	1368	48	2		2	SH3KBP1	23	19764521	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	942355	19764521	135506039	423	33935										
POLA1	5422	broad.mit.edu	37	chrX	24755805	24755805	+	Frame_Shift_Del	DEL	C	C	-													0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gaattaatgtgtgcaaagctCctcactggtccaagataggt							TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:24755805delC	uc004dbl.2	+	19	1992	c.1969delC	c.(1969-1971)CCTfs	p.P657fs		NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	657	Potential.				cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	GTGCAAAGCTCCTCACTGGTC	0.338																		11	202	---	---								-	24755805	C	-	24755805	7	5	110	1	0	1	0	1	0	0	0	0	12187	855	30	0	2043	0	POLA1	23	24755805	Frame_Shift_Del	DEL	C	TCGA-GD-A3OP-01A-21D-A21Z-08	4991284	24755805	130514755	424	33936										
DMD	1756	broad.mit.edu	37	chrX	32328262	32328262	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	gcacagaggtcaggagcattGagaagttgttccacttctaa	11	8	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:32328262G>C	uc004dda.1	-	42	6298	c.6054C>G	c.(6052-6054)CTC>CTG	p.L2018L	DMD_uc004dcw.2_Silent_p.L674L|DMD_uc004dcx.2_Silent_p.L677L|DMD_uc004dcz.2_Silent_p.L1895L|DMD_uc004dcy.1_Silent_p.L2014L|DMD_uc004ddb.1_Silent_p.L2010L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2018	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAGGAGCATTGAGAAGTTGTT	0.393													0	0	0	0.001984	0	5	83										C	32328262	G	C	32328262	2	2	110	1	0	0	0	0	0	0	0	1	4580	1277	45	1		1	DMD	23	32328262	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	7572457	32328262	122942298	425	33937										
SSX3	10214	broad.mit.edu	37	chrX	48214125	48214125	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	acatagacgattttctccgaGactttcatcttttcccactc	4	13	3	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:48214125G>C	uc004djd.1	-	3	220	c.126C>G	c.(124-126)GTC>GTG	p.V42V	SSX3_uc004dje.2_Silent_p.V42V|SSX3_uc010nic.2_Silent_p.V42V	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	42	KRAB-related.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						TTTTCTCCGAGACTTTCATCT	0.398													0	0	0	0.006214	0	9	127										C	48214125	G	C	48214125	2	2	110	1	0	0	0	0	0	0	0	1	15204	929	33	1		1	SSX3	23	48214125	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	15885863	48214125	107056435	426	33938										
GRIPAP1	56850	broad.mit.edu	37	chrX	48855860	48855860	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctggctcaccaacaccattCttgcgtagttcatctgaaag	7	13	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:48855860C>G	uc004dly.1	-	2	134	c.99G>C	c.(97-99)AAG>AAC	p.K33N	GRIPAP1_uc004dma.2_Missense_Mutation_p.K33N	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	33	Potential.					early endosome				breast(2)|kidney(1)	3						CAACACCATTCTTGCGTAGTT	0.552													0	0	0	0.001984	0	4	67										G	48855860	C	G	48855860	3	3	110	1	0	0	0	0	1	0	0	0	6789	912	32	1	2580	1	GRIPAP1	23	48855860	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	641735	48855860	106414700	427	33939										
ITIH5L	347365	broad.mit.edu	37	chrX	54784222	54784222	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctgggatgccaggtttcacaGgtgggacttgtgtcctggag	16	8	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:54784222G>A	uc004dtj.2	-	8	2315	c.2285C>T	c.(2284-2286)CCT>CTT	p.P762L		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	762	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						AGGTTTCACAGGTGGGACTTG	0.532													0	0	0	0.00308	0	7	97										A	54784222	G	A	54784222	3	1	110	1	0	0	0	0	1	0	0	0	7908	1000	35	2	1680	2	ITIH5L	23	54784222	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5928362	54784222	100486338	428	33940										
VSIG4	11326	broad.mit.edu	37	chrX	65253645	65253645	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctttccaaggtcctgttacaCtctctggcacttccaggatg	8	13	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:65253645C>G	uc004dwh.2	-	2	210	c.83G>C	c.(82-84)AGT>ACT	p.S28T	VSIG4_uc004dwi.2_Missense_Mutation_p.S28T|VSIG4_uc010nkq.1_Missense_Mutation_p.S28T|VSIG4_uc004dwj.2_Missense_Mutation_p.S28T|VSIG4_uc011moy.1_Missense_Mutation_p.S28T|VSIG4_uc004dwk.2_Missense_Mutation_p.S28T|VSIG4_uc004dwl.2_5'UTR	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	28	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						TCCTGTTACACTCTCTGGCAC	0.532													0	0	0	0.006214	0	7	96										G	65253645	C	G	65253645	3	3	110	1	0	0	0	0	1	0	0	0	17222	565	20	4	1148	4	VSIG4	23	65253645	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	10469423	65253645	90016915	429	33941										
MAGEE2	139599	broad.mit.edu	37	chrX	75004685	75004685	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctcgtcgatcaggacctccaGgtcattcgggtcctgaacgg	12	13	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:75004685G>T	uc004ecj.1	-	1	387	c.202C>A	c.(202-204)CTG>ATG	p.L68M		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	68										ovary(1)|skin(1)	2						AGGACCTCCAGGTCATTCGGG	0.567													1	0	0.00024832	0.009096	0.000257078	4	71										T	75004685	G	T	75004685	3	4	110	1	0	0	0	0	1	0	0	0	9186	991	35	4	1373	4	MAGEE2	23	75004685	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	9751040	75004685	80265875	430	33942										
LPAR4	2846	broad.mit.edu	37	chrX	78010591	78010591	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	aaaatgagaagtgagactgcTatttttatcaccaatctagc	7	7	2	2			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:78010591T>A	uc010nme.2	+	2	630	c.225T>A	c.(223-225)GCT>GCA	p.A75A		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	75	Helical; Name=2; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						GTGAGACTGCTATTTTTATCA	0.393													0	0	0	0.008291	0	10	209										A	78010591	T	A	78010591	2	1	110	1	0	0	0	0	0	0	0	1	8907	1509	53	5		5	LPAR4	23	78010591	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	3005906	78010591	77259969	431	33943										
LPAR4	2846	broad.mit.edu	37	chrX	78010794	78010794	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tttcctggccattgtctatcCttttcgatctcgtactatta	5	11	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:78010794C>G	uc010nme.2	+	2	833	c.428C>G	c.(427-429)CCT>CGT	p.P143R		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	143	Cytoplasmic (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						ATTGTCTATCCTTTTCGATCT	0.463													0	0	0	0.001168	0	5	122										G	78010794	C	G	78010794	3	3	110	1	0	0	0	0	1	0	0	0	8907	681	24	4	430	4	LPAR4	23	78010794	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	203	78010794	77259766	432	33944										
XKRX	402415	broad.mit.edu	37	chrX	100169786	100169786	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ctgaagtttttctcaatgttAttgggcatctgggcaccact	9	9	2	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:100169786A>T	uc004egn.2	-	3	1496	c.891T>A	c.(889-891)AAT>AAA	p.N297K	XKRX_uc011mre.1_Missense_Mutation_p.N93K	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	297						integral to membrane|plasma membrane				breast(1)	1						TCTCAATGTTATTGGGCATCT	0.493													0	0	0	0.008291	0	9	162										T	100169786	A	T	100169786	3	4	110	1	0	0	0	0	1	0	0	0	17436	446	16	5	462	5	XKRX	23	100169786	Missense_Mutation	SNP	A	TCGA-GD-A3OP-01A-21D-A21Z-08	22158992	100169786	55100774	433	33945										
BTK	695	broad.mit.edu	37	chrX	100617172	100617172	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	cctgtatacctggtcctcctCaggcgttgggggaagaggct	14	11	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:100617172C>T	uc004ehg.2	-	7	770	c.577G>A	c.(577-579)GAG>AAG	p.E193K	BTK_uc010nnn.2_Missense_Mutation_p.E193K|BTK_uc010nno.2_Missense_Mutation_p.E227K|BTK_uc004ehi.2_Missense_Mutation_p.E193K	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	193					calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TGGTCCTCCTCAGGCGTTGGG	0.468									Agammaglobulinemia_X-linked				0	0	0	0.004482	0	7	116										T	100617172	C	T	100617172	3	4	110	1	0	0	0	0	1	0	0	0	1557	835	29	1	1454	1	BTK	23	100617172	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	447386	100617172	54653388	434	33946										
RNF128	79589	broad.mit.edu	37	chrX	105970542	105970542	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	accttcgcagacaagatccaTctggcttatgagagaggggc	12	10	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:105970542T>C	uc004eml.2	+	1	649	c.399T>C	c.(397-399)CAT>CAC	p.H133H	RNF128_uc004emk.2_Intron	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	133	PA.					endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACAAGATCCATCTGGCTTATG	0.597													0	0	0	0.00308	0	6	78										C	105970542	T	C	105970542	2	2	110	1	0	0	0	0	0	0	0	1	13436	1432	50	5		5	RNF128	23	105970542	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	5353370	105970542	49300018	435	33947										
ALG13	79868	broad.mit.edu	37	chrX	110970869	110970869	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	agacgtagtcaccgccagatGagttgtgtgaataaggagtc	13	7	1	4			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:110970869G>A	uc011msy.1	+	18	2152	c.2118G>A	c.(2116-2118)ATG>ATA	p.M706I	ALG13_uc011msx.1_Missense_Mutation_p.M602I|ALG13_uc011msz.1_Missense_Mutation_p.M628I|ALG13_uc011mta.1_Missense_Mutation_p.M602I|ALG13_uc011mtb.1_Missense_Mutation_p.M602I			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	706					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						ACCGCCAGATGAGTTGTGTGA	0.358													0	0	0	0.009096	0	3	25										A	110970869	G	A	110970869	3	1	110	1	0	0	0	0	1	0	0	0	515	1290	45	1	2330	1	ALG13	23	110970869	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5000327	110970869	44299691	436	33948										
KIAA1210	57481	broad.mit.edu	37	chrX	118284333	118284333	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ggtatttccaggtcagtcacTgcagctgggccaagctcccc	11	14	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:118284333T>C	uc004era.3	-	1	210	c.210A>G	c.(208-210)GCA>GCG	p.A70A		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	70										ovary(4)|skin(1)	5						GGTCAGTCACTGCAGCTGGGC	0.547													0	0	0	0.009096	0	3	20										C	118284333	T	C	118284333	2	2	110	1	0	0	0	0	0	0	0	1	8214	1567	55	5		5	KIAA1210	23	118284333	Silent	SNP	T	TCGA-GD-A3OP-01A-21D-A21Z-08	7313464	118284333	36986227	437	33949										
UPF3B	65109	broad.mit.edu	37	chrX	118977197	118977197	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tctatttcctctagcagtgtCtctggagtagatgtcatttt	8	8	4	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:118977197C>G	uc004erz.1	-	5	614	c.537G>C	c.(535-537)GAG>GAC	p.E179D	UPF3B_uc004esa.1_Missense_Mutation_p.E179D	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	179	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						CTAGCAGTGTCTCTGGAGTAG	0.328													0	0	0	0.008291	0	7	154										G	118977197	C	G	118977197	3	3	110	1	0	0	0	0	1	0	0	0	17003	912	32	1	942	1	UPF3B	23	118977197	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	692864	118977197	36293363	438	33950										
CUL4B	8450	broad.mit.edu	37	chrX	119670883	119670883	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tcccggaacattctgattctGcatatactataagaagatca	6	9	3	3			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:119670883G>A	uc004esw.2	-	17	2436	c.1999C>T	c.(1999-2001)CAG>TAG	p.Q667*	CUL4B_uc010nqq.2_Nonsense_Mutation_p.Q368*|CUL4B_uc004esv.2_Nonsense_Mutation_p.Q649*	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	667					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTCTGATTCTGCATATACTAT	0.348													0	0	0	0.001855	0	11	105										A	119670883	G	A	119670883	4	1	110	1	0	0	0	0	0	1	0	0	4058	1328	46	2	766	2	CUL4B	23	119670883	Nonsense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	693686	119670883	35599677	439	33951										
DCAF12L2	340578	broad.mit.edu	37	chrX	125299261	125299261	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccatccgccacagagccacgGtgccgtcgcgggagccgctc	13	18	0	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:125299261G>T	uc004euk.1	-	1	674	c.647C>A	c.(646-648)ACC>AAC	p.T216N		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	216	WD 2.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CAGAGCCACGGTGCCGTCGCG	0.637													1	0	7.07596e-05	0.006122	7.41786e-05	15	76										T	125299261	G	T	125299261	3	4	110	1	0	0	0	0	1	0	0	0	4265	1261	44	4	748	4	DCAF12L2	23	125299261	Missense_Mutation	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	5628378	125299261	29971299	440	33952										
ATP2B3	492	broad.mit.edu	37	chrX	152821836	152821836	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	tggcccaagctgagggtgctGgcccggtcgtctcccaccga	14	15	1	1			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:152821836G>A	uc004fht.1	+	13	2412	c.2286G>A	c.(2284-2286)CTG>CTA	p.L762L	ATP2B3_uc004fhs.1_Silent_p.L762L	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	762	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGGTGCTGGCCCGGTCGT	0.652													0	0	0	0.004672	0	3	24										A	152821836	G	A	152821836	2	1	110	1	0	0	0	0	0	0	0	1	1141	1335	47	2		2	ATP2B3	23	152821836	Silent	SNP	G	TCGA-GD-A3OP-01A-21D-A21Z-08	27522575	152821836	2448724	441	33953										
HCFC1	3054	broad.mit.edu	37	chrX	153224215	153224215	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	atctgtgggctactgccaatCacctgcagcaggcacgggca	12	13	2	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:153224215C>A	uc004fjp.2	-	10	2136	c.1608G>T	c.(1606-1608)GTG>GTT	p.V536V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	536					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TACTGCCAATCACCTGCAGCA	0.677													1	0	0.00909568	0.009096	0.00928169	3	23										A	153224215	C	A	153224215	2	1	110	1	0	0	0	0	0	0	0	1	6991	813	29	3		3	HCFC1	23	153224215	Silent	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	402379	153224215	2046345	442	33954										
FLNA	2316	broad.mit.edu	37	chrX	153596245	153596245	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.474885844748858	208	1.05657404261676e-75	3.95994082166837	5.09165467828834	3.45066958618939	9.22969517426834e-05	0.000567380733791028	155	ccaccagggcgcccagggccCggccgctctgccagtcccgg	14	20	1	0			TCGA-GD-A3OP-01A-21D-A21Z-08	TCGA-GD-A3OP-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e02d723-691a-448c-85e2-4e39a3696ba5	1da60c80-b916-476e-b5f6-ed860171f568	g.chrX:153596245C>T	uc004fkk.2	-	3	836	c.587G>A	c.(586-588)CGG>CAG	p.R196Q	FLNA_uc010nuu.1_Missense_Mutation_p.R196Q	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	196	CH 2.|Actin-binding.		R -> W (in OPD1).|R -> G (in OPD2).		actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCAGGGCCCGGCCGCTCTG	0.692													0	0	0	0.006214	0	7	54										T	153596245	C	T	153596245	3	4	110	1	0	0	0	0	1	0	0	0	5933	652	23	2	7540	2	FLNA	23	153596245	Missense_Mutation	SNP	C	TCGA-GD-A3OP-01A-21D-A21Z-08	372030	153596245	1674315	443	33955										
CHD5	26038	broad.mit.edu	37	chr1	6188917	6188917	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ccctccacgtcgtccttgaaGagttcctccgtgccgaactt	8	16	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:6188917G>C	uc001amb.1	-	23	3700	c.3600C>G	c.(3598-3600)CTC>CTG	p.L1200L	CHD5_uc001alz.1_Silent_p.L57L|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1200					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGTCCTTGAAGAGTTCCTCCG	0.667													0	0	0	0.248553	0	6	69										C	6188917	G	C	6188917	2	2	111	1	0	0	0	0	0	0	0	1	3328	929	33	1		1	CHD5	1	6188917	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		6188917	243061704	1	33956										
MASP2	10747	broad.mit.edu	37	chr1	11105485	11105485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgagcaggtgcgcttgttaCggtgcaggacgtagcctgcg	16	10	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:11105485C>T	uc001aru.2	-	4	545	c.524G>A	c.(523-525)CGT>CAT	p.R175H	MASP2_uc001arv.2_Missense_Mutation_p.R175H|MASP2_uc001arw.2_3'UTR|MASP2_uc001arx.1_Missense_Mutation_p.R175H	NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	175	EGF-like; calcium-binding.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GCGCTTGTTACGGTGCAGGAC	0.687													0	0	0	0.788014	0	29	47										T	11105485	C	T	11105485	3	4	111	1	0	0	0	0	1	0	0	0	9323	536	19	2	1586	2	MASP2	1	11105485	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	4916568	11105485	238145136	2	33957										
UBR4	23352	broad.mit.edu	37	chr1	19491418	19491418	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtgagccaggcctgcaggcgCacaggttccacacaggccag	14	14	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:19491418C>T	uc001bbi.2	-	32	4390	c.4386G>A	c.(4384-4386)GTG>GTA	p.V1462V	UBR4_uc001bbm.1_Silent_p.V673V	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1462					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCTGCAGGCGCACAGGTTCCA	0.577													0	0	0	0.435327	0	11	59										T	19491418	C	T	19491418	2	4	111	1	0	0	0	0	0	0	0	1	16901	697	25	2		2	UBR4	1	19491418	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	8385933	19491418	229759203	3	33958										
MACF1	23499	broad.mit.edu	37	chr1	39801075	39801075	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgaagaaataagagaaaatCaaggggaagtgattttggaa	12	2	1	4			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:39801075C>G	uc010oiu.1	+	1	4266	c.4135C>G	c.(4135-4137)CAA>GAA	p.Q1379E	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2944					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGAGAAAATCAAGGGGAAGT	0.378													0	0	0	0.361761	0	8	81										G	39801075	C	G	39801075	3	3	111	1	0	0	0	0	1	0	0	0	9144	827	29	1	8906	1	MACF1	1	39801075	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	20309657	39801075	209449546	4	33959										
KCNQ4	9132	broad.mit.edu	37	chr1	41285143	41285143	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cgactcgctctggtgggggaCggtgcgtgagggtctttgta	18	8	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:41285143C>T	uc001cgh.1	+	5	915	c.833C>T	c.(832-834)ACG>ATG	p.T278M	KCNQ4_uc001cgi.1_Missense_Mutation_p.T278M	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	278					sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TGGTGGGGGACGGTGCGTGAG	0.627													0	0	0	0.361761	0	9	149										T	41285143	C	T	41285143	3	4	111	1	0	0	0	0	1	0	0	0	8085	550	19	2	851	2	KCNQ4	1	41285143	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	1484068	41285143	207965478	5	33960										
ZFYVE9	9372	broad.mit.edu	37	chr1	52740153	52740153	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tagacggatatttgtctattCtctgggagtataactcaggt	10	6	3	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:52740153C>G	uc001cto.2	+	8	2815	c.2643C>G	c.(2641-2643)TTC>TTG	p.F881L	ZFYVE9_uc001ctp.2_Missense_Mutation_p.F822L	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	881					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TTTGTCTATTCTCTGGGAGTA	0.398													0	0	0	0.307466	0	6	190										G	52740153	C	G	52740153	3	3	111	1	0	0	0	0	1	0	0	0	17668	912	32	1	2676	1	ZFYVE9	1	52740153	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	11455010	52740153	196510468	6	33961										
INADL	10207	broad.mit.edu	37	chr1	62614061	62614061	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aacaccatccagaagacacaGagtgagtatttcagatgcag	9	9	1	5			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:62614061G>C	uc001dab.2	+	42	5491	c.5377G>C	c.(5377-5379)GAG>CAG	p.E1793Q	INADL_uc001dac.2_RNA|INADL_uc009wag.2_Missense_Mutation_p.E577Q	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1793					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AGAAGACACAGAGTGAGTATT	0.478													0	0	0	0.819951	0	35	95										C	62614061	G	C	62614061	3	2	111	1	0	0	0	0	1	0	0	0	7731	956	33	1	5539	1	INADL	1	62614061	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	9873908	62614061	186636560	7	33962										
TNNI3K	51086	broad.mit.edu	37	chr1	74954930	74954930	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aagagtgtctctgcaacattGaggtaaaagctttagcttct	9	7	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:74954930G>A	uc001dgf.1	+	22	2230	c.2179G>A	c.(2179-2181)GAG>AAG	p.E727K	TNNI3K_uc001dge.1_Missense_Mutation_p.E828K	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	727						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						CTGCAACATTGAGGTAAAAGC	0.373													0	0	0	0.217242	0	6	63										A	74954930	G	A	74954930	3	1	111	1	0	0	0	0	1	0	0	0	16326	1291	45	1	2620	1	TNNI3K	1	74954930	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	12340869	74954930	174295691	8	33963										
ZNHIT6	54680	broad.mit.edu	37	chr1	86173471	86173471	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttatgcattgaccaacaaacTtctcctcctgttttatctcc	3	13	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:86173471T>C	uc001dlh.2	-	1	631	c.497A>G	c.(496-498)AAG>AGG	p.K166R	ZNHIT6_uc010osc.1_Missense_Mutation_p.K127R	NM_017953	NP_060423	Q9NWK9	BCD1_HUMAN	zinc finger, HIT type 6	166	Glu-rich.				box C/D snoRNP assembly|ribosome biogenesis	pre-snoRNP complex	identical protein binding|metal ion binding			large_intestine(1)	1						ACCAACAAACTTCTCCTCCTG	0.408													0	0	0	0.819951	0	29	237										C	86173471	T	C	86173471	3	2	111	1	0	0	0	0	1	0	0	0	18206	1609	56	5	955	5	ZNHIT6	1	86173471	Missense_Mutation	SNP	T	TCGA-GD-A3OQ-01A-32D-A21Z-08	11218541	86173471	163077150	9	33964										
C1orf183	55924	broad.mit.edu	37	chr1	112269624	112269624	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgtgttaatatcaaatcctGagggtgagtgctccagggcc	12	9	1	2	rs112881255		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:112269624G>A	uc001ebo.1	-	2	1018	c.860C>T	c.(859-861)TCA>TTA	p.S287L	C1orf183_uc001ebp.1_Missense_Mutation_p.S272L	NM_019099	NP_061972	Q9NTI7	CA183_HUMAN	hypothetical protein LOC55924 isoform 1	287										ovary(2)	2		all_cancers(81;7.29e-06)|all_epithelial(167;4.98e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.16e-05)		Lung(183;0.0155)|Colorectal(144;0.0289)|all cancers(265;0.0592)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0852)|COAD - Colon adenocarcinoma(174;0.113)		ATCAAATCCTGAGGGTGAGTG	0.597													0	0	0	0.859065	0	34	310										A	112269624	G	A	112269624	3	1	111	1	0	0	0	0	1	0	0	0	2019	1294	45	1	37	1	C1orf183	1	112269624	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	26096153	112269624	136980997	10	33965										
AMPD1	270	broad.mit.edu	37	chr1	115220970	115220970	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctacagcatgaacatccagaGaatcaacagtcaggtcataa	7	10	3	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:115220970G>C	uc001efe.1	-	8	1160	c.1076C>G	c.(1075-1077)TCT>TGT	p.S359C	AMPD1_uc001eff.1_Missense_Mutation_p.S355C	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	359					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	AACATCCAGAGAATCAACAGT	0.428													0	0	0	0.639603	0	19	150										C	115220970	G	C	115220970	3	2	111	1	0	0	0	0	1	0	0	0	585	942	33	1	1203	1	AMPD1	1	115220970	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	2951346	115220970	134029651	11	33966										
LYSMD1	388695	broad.mit.edu	37	chr1	151134376	151134376	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttggcacgtcctgctcctgtCtcttgtttcttcctctcagt	7	14	3	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:151134376C>G	uc001ewy.2	-	2	1017	c.381G>C	c.(379-381)GAG>GAC	p.E127D	LYSMD1_uc010pcr.1_Missense_Mutation_p.E79D	NM_212551	NP_997716	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain	127					cell wall macromolecule catabolic process						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGCTCCTGTCTCTTGTTTCT	0.507													0	0	0	0.335167	0	10	70										G	151134376	C	G	151134376	3	3	111	1	0	0	0	0	1	0	0	0	9124	912	32	1	310	1	LYSMD1	1	151134376	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	35913406	151134376	98116245	12	33967										
FLG	2312	broad.mit.edu	37	chr1	152282758	152282758	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tgcttgcacttctgggtcctGactgcccatgggaggcatca	12	12	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:152282758G>C	uc001ezu.1	-	3	4640	c.4604C>G	c.(4603-4605)TCA>TGA	p.S1535*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1535	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTGGGTCCTGACTGCCCATG	0.567									Ichthyosis				0	0	0	0.870114	0	47	377										C	152282758	G	C	152282758	4	2	111	1	0	0	0	0	0	1	0	0	5922	1294	45	1	7585	1	FLG	1	152282758	Nonsense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	1148382	152282758	96967863	13	33968										
SEMA4A	64218	broad.mit.edu	37	chr1	156131202	156131202	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttcctgaaggcccagctgctCtgcacccagccggggcagct	12	16	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:156131202C>G	uc001fnl.2	+	9	980	c.876C>G	c.(874-876)CTC>CTG	p.L292L	SEMA4A_uc009wrq.2_Silent_p.L292L|SEMA4A_uc001fnm.2_Silent_p.L292L|SEMA4A_uc001fnn.2_Silent_p.L160L|SEMA4A_uc001fno.2_Silent_p.L292L	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	292	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCCAGCTGCTCTGCACCCAGC	0.667													0	0	0	0.520397	0	16	102										G	156131202	C	G	156131202	2	3	111	1	0	0	0	0	0	0	0	1	14031	900	32	1		1	SEMA4A	1	156131202	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	3848444	156131202	93119419	14	33969										
PAPPA2	60676	broad.mit.edu	37	chr1	176564215	176564215	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gccagagcctgagattctgtCgcctttgcagcccccactct	9	16	2	2	rs116090626	by1000genomes	TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:176564215C>T	uc001gkz.2	+	3	2639	c.1475C>T	c.(1474-1476)TCG>TTG	p.S492L	PAPPA2_uc001gky.1_Missense_Mutation_p.S492L|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	492	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAGATTCTGTCGCCTTTGCAG	0.522													0	0	0	0.608945	0	21	35										T	176564215	C	T	176564215	3	4	111	1	0	0	0	0	1	0	0	0	11433	893	31	1	1481	1	PAPPA2	1	176564215	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	20433013	176564215	72686406	15	33970										
TLR5	7100	broad.mit.edu	37	chr1	223284277	223284277	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	catgtgaagtctttgctgctGaagcacaaataggcatcata	9	8	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:223284277G>T	uc001hnv.1	-	4	2543	c.2097C>A	c.(2095-2097)TTC>TTA	p.F699L	TLR5_uc001hnw.1_Missense_Mutation_p.F699L	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	699	Cytoplasmic (Potential).|TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		CTTTGCTGCTGAAGCACAAAT	0.438													1	0	0.000602214	0.184627	0.000619927	4	90										T	223284277	G	T	223284277	3	4	111	1	0	0	0	0	1	0	0	0	15951	1281	45	3	483	3	TLR5	1	223284277	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	46720062	223284277	25966344	16	33971										
FBXO28	23219	broad.mit.edu	37	chr1	224318184	224318184	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctccttgaaggtttgtaaaaGaatggacttggtctgccaga	11	7	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:224318184G>C	uc001hoh.2	+	2	319	c.278G>C	c.(277-279)AGA>ACA	p.R93T	FBXO28_uc009xef.2_Missense_Mutation_p.R93T|FBXO28_uc010pvc.1_5'UTR	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	93	F-box.									ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		GTTTGTAAAAGAATGGACTTG	0.373													0	0	0	0.307466	0	8	74										C	224318184	G	C	224318184	3	2	111	1	0	0	0	0	1	0	0	0	5738	942	33	1	284	1	FBXO28	1	224318184	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	1033907	224318184	24932437	17	33972										
RYR2	6262	broad.mit.edu	37	chr1	237947659	237947659	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ggacttgaacgagaggtcagCgaataaggaagaaagcgaga	15	5	1	4			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr1:237947659C>T	uc001hyl.1	+	90	12767	c.12647C>T	c.(12646-12648)GCG>GTG	p.A4216V	RYR2_uc010pya.1_Missense_Mutation_p.A631V	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4216					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGAGGTCAGCGAATAAGGAA	0.542													0	0	0	0.729181	0	25	40										T	237947659	C	T	237947659	3	4	111	1	0	0	0	0	1	0	0	0	13769	768	27	2	13005	2	RYR2	1	237947659	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	13629475	237947659	11302962	18	33973										
ITSN2	50618	broad.mit.edu	37	chr2	24521611	24521611	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttcttgttctctattcttttGattgagaagctcctgtcgcc	7	10	3	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:24521611G>C	uc002rfe.2	-	13	1675	c.1417C>G	c.(1417-1419)CAA>GAA	p.Q473E	ITSN2_uc002rff.2_Missense_Mutation_p.Q473E|ITSN2_uc002rfg.2_Missense_Mutation_p.Q473E|ITSN2_uc010eyd.2_Missense_Mutation_p.Q498E	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	473	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTATTCTTTTGATTGAGAAGC	0.368													0	0	0	0.457914	0	11	101										C	24521611	G	C	24521611	3	2	111	1	0	0	0	0	1	0	0	0	7927	1299	45	1	3839	1	ITSN2	2	24521611	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		24521611	218677762	19	33974										
AFTPH	54812	broad.mit.edu	37	chr2	64778744	64778744	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cttctggtgtagggtttgttGatttcgatacaccagattat	10	6	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:64778744G>C	uc002sdc.2	+	1	168	c.136G>C	c.(136-138)GAT>CAT	p.D46H	AFTPH_uc002scz.2_Missense_Mutation_p.D46H|AFTPH_uc002sda.2_Missense_Mutation_p.D46H|AFTPH_uc002sdb.2_Missense_Mutation_p.D46H	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	46					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						AGGGTTTGTTGATTTCGATAC	0.408													0	0	0	0.870114	0	99	132										C	64778744	G	C	64778744	3	2	111	1	0	0	0	0	1	0	0	0	364	1290	45	1	138	1	AFTPH	2	64778744	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	40257133	64778744	178420629	20	33975										
LOC285033	285033	broad.mit.edu	37	chr2	96906235	96906235	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	acatctcgggtcaactcttcTcaggaccagatccaagtcgc	8	14	4	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:96906235T>A	uc002svp.1	+	1	259	c.174T>A	c.(172-174)TCT>TCA	p.S58S	LOC285033_uc002svn.2_RNA|LOC285033_uc002svo.2_Silent_p.S135S	NM_001037228	NP_001032305	Q3KRF4	Q3KRF4_HUMAN	hypothetical protein LOC285033	58											0						TCAACTCTTCTCAGGACCAGA	0.537													0	0	0	0.27861	0	5	88										A	96906235	T	A	96906235	2	1	111	1	0	0	0	0	0	0	0	1	8873	1538	54	5		5	LOC285033	2	96906235	Silent	SNP	T	TCGA-GD-A3OQ-01A-32D-A21Z-08	32127491	96906235	146293138	21	33976										
ANKRD36	375248	broad.mit.edu	37	chr2	97869979	97869979	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	atatagccagaggaaaaaagGatggagaaaaaactaggaca	11	4	0	2	rs111515821		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:97869979G>T	uc010yva.1	+	50	3284	c.3040G>T	c.(3040-3042)GAT>TAT	p.D1014Y	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1014											0						AGGAAAAAAGGATGGAGAAAA	0.289													1	0	0.004672	0.115264	0.00473971	3	9										T	97869979	G	T	97869979	3	4	111	1	0	0	0	0	1	0	0	0	665	1174	41	3	3238	3	ANKRD36	2	97869979	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	963744	97869979	145329394	22	33977										
AFF3	3899	broad.mit.edu	37	chr2	100210557	100210557	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tccttgcaagtgctcttgatCtccttctctctcaggctggg	9	13	4	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:100210557C>G	uc002tag.2	-	14	1802	c.1566G>C	c.(1564-1566)GAG>GAC	p.E522D	AFF3_uc002taf.2_Missense_Mutation_p.E547D|AFF3_uc010fiq.1_Missense_Mutation_p.E522D|AFF3_uc010yvr.1_Missense_Mutation_p.E675D|AFF3_uc002tah.1_Missense_Mutation_p.E547D	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	522					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TGCTCTTGATCTCCTTCTCTC	0.602													0	0	0	0.248553	0	6	132										G	100210557	C	G	100210557	3	3	111	1	0	0	0	0	1	0	0	0	358	912	32	1	2158	1	AFF3	2	100210557	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	2340578	100210557	142988816	23	33978										
LY75	4065	broad.mit.edu	37	chr2	160628465	160628465	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aaaaaactgtggtgaaacgaGaatcagaatgttttttgtac	9	4	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:160628465G>T	uc002ubb.3	-	39	5588	c.5519C>A	c.(5518-5520)TCT>TAT	p.S1840Y	LY75_uc010fos.2_Missense_Mutation_p.S1784Y|CD302_uc002uba.2_Missense_Mutation_p.S199Y|CD302_uc010zco.1_Missense_Mutation_p.S141Y	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		GGTGAAACGAGAATCAGAATG	0.368													1	0	2.42023e-17	0.779181	2.54761e-17	28	59										T	160628465	G	T	160628465	3	4	111	1	0	0	0	0	1	0	0	0	9099	942	33	3		3	LY75	2	160628465	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	60417908	160628465	82570908	24	33979										
PLA2R1	22925	broad.mit.edu	37	chr2	160808060	160808060	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	attgggcattggatacatatCagatgtatttacaccgtgtc	9	7	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:160808060C>G	uc002ube.1	-	24	3538	c.3331G>C	c.(3331-3333)GAT>CAT	p.D1111H	PLA2R1_uc010zcp.1_Missense_Mutation_p.D1111H|PLA2R1_uc002ubf.2_Missense_Mutation_p.D1111H	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1111	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GGATACATATCAGATGTATTT	0.363													0	0	0	0.115264	0	3	88										G	160808060	C	G	160808060	3	3	111	1	0	0	0	0	1	0	0	0	12010	826	29	1	1096	1	PLA2R1	2	160808060	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	179595	160808060	82391313	25	33980										
SCN1A	6323	broad.mit.edu	37	chr2	166848014	166848014	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aaaggtggcgtctgtaagcaCgctgaataatgacagcagat	12	7	1	3	rs3749029		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:166848014C>A	uc010zcz.1	-	26	5756	c.5738G>T	c.(5737-5739)CGT>CTT	p.R1913L		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1924						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCTGTAAGCACGCTGAATAAT	0.388													1	0	6.04164e-23	0.750413	6.4078e-23	28	64										A	166848014	C	A	166848014	3	1	111	1	0	0	0	0	1	0	0	0	13914	536	19	4	262	4	SCN1A	2	166848014	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	6039954	166848014	76351359	26	33981										
SF3B1	23451	broad.mit.edu	37	chr2	198265573	198265573	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caccatttttctgtactgttCggcttcatctttcagatcat	5	11	5	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:198265573C>T	uc002uue.2	-	18	2632	c.2584G>A	c.(2584-2586)GAA>AAA	p.E862K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	862	HEAT 7.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTGTACTGTTCGGCTTCATCT	0.373													0	0	0	0.479597	0	13	82										T	198265573	C	T	198265573	3	4	111	1	0	0	0	0	1	0	0	0	14149	893	31	1	1362	1	SF3B1	2	198265573	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	31417559	198265573	44933800	27	33982										
GIGYF2	26058	broad.mit.edu	37	chr2	233710441	233710441	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caccctattgttttgctttaGtaaatctgtaggtgtgtcta	8	7	2	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr2:233710441G>A	uc002vti.3	+	28	3643	c.3306_splice	c.e28-1	p.S1102_splice	GIGYF2_uc002vtj.3_Splice_Site_p.S1123_splice|GIGYF2_uc002vtk.3_Splice_Site_p.S1102_splice|GIGYF2_uc002vth.3_Splice_Site_p.S1096_splice|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc002vtq.3_Splice_Site_p.S435_splice	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTTTGCTTTAGTAAATCTGTA	0.353													0	0	0	0.520397	0	16	44										A	233710441	G	A	233710441	5	1	111	1	0	0	0	0	0	0	1	0	6378	1043	36	2	3469	2	GIGYF2	2	233710441	Splice_Site	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	35444868	233710441	9488932	28	33983										
GRM7	2917	broad.mit.edu	37	chr3	7456742	7456742	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	actttacgtcccgtacacttGaaaacaacagaagaaatgta	6	9	0	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:7456742G>A	uc003bqm.2	+	5	1340	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.E356K|GRM7_uc003bql.2_Missense_Mutation_p.E356K|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	356	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CCGTACACTTGAAAACAACAG	0.403													0	0	0	0.435327	0	12	31										A	7456742	G	A	7456742	3	1	111	1	0	0	0	0	1	0	0	0	6802	1291	45	1	1084	1	GRM7	3	7456742	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		7456742	190565688	29	33984										
CELSR3	1951	broad.mit.edu	37	chr3	48699002	48699002	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtagactaggcgcccggcctCgccggcgtccgggtcctgag	16	15	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:48699002C>G	uc003cul.2	-	1	1347	c.1066G>C	c.(1066-1068)GAG>CAG	p.E356Q	CELSR3_uc003cuf.1_Missense_Mutation_p.E426Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	356	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CGCCCGGCCTCGCCGGCGTCC	0.672													0	0	0	0.457914	0	12	51										G	48699002	C	G	48699002	3	3	111	1	0	0	0	0	1	0	0	0	3223	893	31	1	9012	1	CELSR3	3	48699002	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	41242260	48699002	149323428	30	33985										
SEMA5B	54437	broad.mit.edu	37	chr3	122634684	122634684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tgtcctcgagtgtgctgcaaCgttgctgcttcccgtcccag	11	14	0	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:122634684C>T	uc003efz.1	-	13	2046	c.1742G>A	c.(1741-1743)CGT>CAT	p.R581H	SEMA5B_uc011bju.1_Missense_Mutation_p.R523H|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.R581H|SEMA5B_uc010hro.1_Missense_Mutation_p.R523H	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	581	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGTGCTGCAACGTTGCTGCTT	0.622													0	0	0	0.788014	0	32	44										T	122634684	C	T	122634684	3	4	111	1	0	0	0	0	1	0	0	0	14038	536	19	2	1757	2	SEMA5B	3	122634684	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	73935682	122634684	75387746	31	33986										
MRPL3	11222	broad.mit.edu	37	chr3	131220433	131220433	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	agaggacacagtttacttgcTaattgggctttatcttcatc	8	8	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:131220433T>C	uc003eoh.2	-	2	383	c.219A>G	c.(217-219)TTA>TTG	p.L73L	MRPL3_uc011blo.1_5'UTR|MRPL3_uc011blp.1_Silent_p.L100L	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	73					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						GTTTACTTGCTAATTGGGCTT	0.398													0	0	0	0.870114	0	96	184										C	131220433	T	C	131220433	2	2	111	1	0	0	0	0	0	0	0	1	9793	1519	53	5		5	MRPL3	3	131220433	Silent	SNP	T	TCGA-GD-A3OQ-01A-32D-A21Z-08	8585749	131220433	66801997	32	33987										
WDR49	151790	broad.mit.edu	37	chr3	167254660	167254660	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	agtgaaagttcaatttacccGtaacaagagtttgtggaggt	11	5	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr3:167254660G>A	uc003fev.1	-	7	1202	c.896C>T	c.(895-897)ACG>ATG	p.T299M	WDR49_uc003feu.1_Missense_Mutation_p.T124M|WDR49_uc011bpd.1_Missense_Mutation_p.T363M|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	299	WD 5.									large_intestine(1)|ovary(1)|skin(1)	3						CAATTTACCCGTAACAAGAGT	0.373													0	0	0	0.520397	0	14	26										A	167254660	G	A	167254660	3	1	111	1	0	0	0	0	1	0	0	0	17299	1145	40	2	1233	2	WDR49	3	167254660	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	36034227	167254660	30767770	33	33988										
PDGFRA	5156	broad.mit.edu	37	chr4	54248502	54248502	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gaaaatggtgtaccaaaaccGgtaacataaggctttgaaat	9	6	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:54248502G>A	uc003haa.2	+	4	414	c.228G>A	c.(226-228)CCG>CCA	p.P76P	FIP1L1_uc003gzx.3_Silent_p.P61P|FIP1L1_uc011bzt.1_Silent_p.P76P|FIP1L1_uc003gzy.2_Silent_p.P76P|FIP1L1_uc011bzu.1_Silent_p.P61P|FIP1L1_uc003gzz.2_Silent_p.P61P|FIP1L1_uc003hab.2_Silent_p.P64P|FIP1L1_uc003hac.2_5'UTR	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TACCAAAACCGGTAACATAAG	0.348			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.361761	0	9	69										A	54248502	G	A	54248502	2	1	111	1	0	0	0	0	0	0	0	1	11661	1130	39	2		2	PDGFRA	4	54248502	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		54248502	136905774	34	33989										
PDGFRA	5156	broad.mit.edu	37	chr4	54257217	54257217	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttaattatgggtttaatgaaGatacctggaaagcttactgt	9	4	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:54257217G>C	uc003haa.2	+	8	733	c.547G>C	c.(547-549)GAT>CAT	p.D183H	FIP1L1_uc003gzx.3_Missense_Mutation_p.D168H|FIP1L1_uc011bzt.1_Missense_Mutation_p.D183H|FIP1L1_uc003gzy.2_Missense_Mutation_p.D183H|FIP1L1_uc011bzu.1_Missense_Mutation_p.D168H|FIP1L1_uc003gzz.2_Missense_Mutation_p.D168H|FIP1L1_uc003hab.2_Missense_Mutation_p.D171H|FIP1L1_uc003hac.2_5'UTR	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:Variant_position_missing_in_P16234_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTTTAATGAAGATACCTGGAA	0.303			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.184627	0	4	58										C	54257217	G	C	54257217	3	2	111	1	0	0	0	0	1	0	0	0	11661	942	33	1		1	PDGFRA	4	54257217	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	8715	54257217	136897059	35	33990										
CXCL11	6373	broad.mit.edu	37	chr4	76956259	76956259	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gcatcgttgtcctttattttCtttcagggtaatactgttaa	7	7	2	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:76956259C>G	uc003hjm.2	-	3	295	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_005409	NP_005400	O14625	CXL11_HUMAN	small inducible cytokine B11 precursor	68					cell-cell signaling|chemotaxis|inflammatory response|signal transduction	extracellular space	chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCTTTATTTTCTTTCAGGGTA	0.333													0	0	0	0.435327	0	11	73										G	76956259	C	G	76956259	3	3	111	1	0	0	0	0	1	0	0	0	4079	922	32	1	90	1	CXCL11	4	76956259	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	22699042	76956259	114198017	36	33991										
LRBA	987	broad.mit.edu	37	chr4	151357947	151357947	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	atagtgaaactttggaacttGatcatcttcccatgattcat	6	8	3	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr4:151357947G>A	uc010ipj.2	-	46	7357	c.6883C>T	c.(6883-6885)CAA>TAA	p.Q2295*	LRBA_uc010ipi.2_5'UTR|LRBA_uc003ils.3_Nonsense_Mutation_p.Q185*|LRBA_uc003ilt.3_Nonsense_Mutation_p.Q943*|LRBA_uc003ilu.3_Nonsense_Mutation_p.Q2284*	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2295	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTTGGAACTTGATCATCTTCC	0.393													0	0	0	0.435327	0	11	38										A	151357947	G	A	151357947	4	1	111	1	0	0	0	0	0	1	0	0	8931	1299	45	1	1760	1	LRBA	4	151357947	Nonsense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	74401688	151357947	39796329	37	33992										
SLC9A3	6550	broad.mit.edu	37	chr5	485324	485324	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cacctcccagcgccacgaaaGattcaaacacattgtacaga	6	14	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:485324G>A	uc003jbe.2	-	4	810	c.698C>T	c.(697-699)TCT>TTT	p.S233F	SLC9A3_uc011clx.1_Missense_Mutation_p.S233F	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	233	Extracellular (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGCCACGAAAGATTCAAACAC	0.632													0	0	0	0.740014	0	26	74										A	485324	G	A	485324	3	1	111	1	0	0	0	0	1	0	0	0	14713	942	33	1	1862	1	SLC9A3	5	485324	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		485324	180429936	38	33993										
SRD5A1	6715	broad.mit.edu	37	chr5	6656219	6656219	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttgtggttaacgggcatgttGataaacatccattcagatca	9	7	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:6656219G>T	uc003jdw.2	+	3	679	c.489G>T	c.(487-489)TTG>TTT	p.L163F	SRD5A1_uc011cml.1_RNA|SRD5A1_uc011cmm.1_Missense_Mutation_p.L116F	NM_001047	NP_001038	P18405	S5A1_HUMAN	steroid-5-alpha-reductase 1	163	Helical; (Potential).				androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity				0					Dutasteride(DB01126)|Finasteride(DB01216)	CGGGCATGTTGATAAACATCC	0.388													1	0	1.10513e-12	0.624587	1.15462e-12	16	30										T	6656219	G	T	6656219	3	4	111	1	0	0	0	0	1	0	0	0	15137	1281	45	3	499	3	SRD5A1	5	6656219	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	6170895	6656219	174259041	39	33994										
CTNND2	1501	broad.mit.edu	37	chr5	10981933	10981933	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gcaccataagaattcctataCaaagttgaaattccagtgtt	6	8	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:10981933C>T	uc003jfa.1	-	21	3514	c.3369G>A	c.(3367-3369)TTG>TTA	p.L1123L	CTNND2_uc010itt.2_Silent_p.L1032L|CTNND2_uc011cmy.1_Silent_p.L786L|CTNND2_uc011cmz.1_Silent_p.L690L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.L715L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1123					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AATTCCTATACAAAGTTGAAA	0.343													0	0	0	0.435327	0	10	125										T	10981933	C	T	10981933	2	4	111	1	0	0	0	0	0	0	0	1	4020	477	17	2		2	CTNND2	5	10981933	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	4325714	10981933	169933327	40	33995										
ERBB2IP	55914	broad.mit.edu	37	chr5	65310528	65310528	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tccaaatattagagcttagaGaaaaccagttaaaaatgttg	7	5	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:65310528G>A	uc003juk.1	+	7	816	c.508G>A	c.(508-510)GAA>AAA	p.E170K	ERBB2IP_uc003juh.1_Missense_Mutation_p.E170K|ERBB2IP_uc003jui.1_Missense_Mutation_p.E170K|ERBB2IP_uc003juj.1_Missense_Mutation_p.E170K|ERBB2IP_uc011cqx.1_Missense_Mutation_p.E170K|ERBB2IP_uc011cqy.1_Missense_Mutation_p.E170K|ERBB2IP_uc011cqz.1_Missense_Mutation_p.E170K|ERBB2IP_uc010iwx.1_Missense_Mutation_p.E170K|ERBB2IP_uc003jul.1_Missense_Mutation_p.E170K	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	170	LRR 7.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		AGAGCTTAGAGAAAACCAGTT	0.184													0	0	0	0.307466	0	7	24										A	65310528	G	A	65310528	3	1	111	1	0	0	0	0	1	0	0	0	5207	943	33	1	526	1	ERBB2IP	5	65310528	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	54328595	65310528	115604732	41	33996										
DMXL1	1657	broad.mit.edu	37	chr5	118485340	118485340	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aaaacagagtaactccagttCtgggttacatcctccaaaga	7	10	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:118485340C>T	uc003ksd.2	+	18	3999	c.3818C>T	c.(3817-3819)TCT>TTT	p.S1273F	DMXL1_uc010jcl.1_Missense_Mutation_p.S1273F	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1273										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AACTCCAGTTCTGGGTTACAT	0.403													0	0	0	0.27861	0	7	69										T	118485340	C	T	118485340	3	4	111	1	0	0	0	0	1	0	0	0	4594	913	32	1	3888	1	DMXL1	5	118485340	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	53174812	118485340	62429920	42	33997										
PCDHA7	56141	broad.mit.edu	37	chr5	140214244	140214244	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtgaattctcggatcgaccgCgaggagctgtgcgggcggag	18	9	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:140214244C>G	uc003lhq.2	+	1	276	c.276C>G	c.(274-276)CGC>CGG	p.R92R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R92R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCGACCGCGAGGAGCTGT	0.587													0	0	0	0.870114	0	83	570										G	140214244	C	G	140214244	2	3	111	1	0	0	0	0	0	0	0	1	11529	755	27	4		4	PCDHA7	5	140214244	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	21728904	140214244	40701016	43	33998										
PCDHA9	9752	broad.mit.edu	37	chr5	140228356	140228356	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtgaattctcggatcgaccgCgaggagctgtgcgggcggag	18	9	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:140228356C>G	uc003lhu.2	+	1	1000	c.276C>G	c.(274-276)CGC>CGG	p.R92R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.R92R	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATCGACCGCGAGGAGCTGT	0.587													0	0	0	0.870114	0	46	19										G	140228356	C	G	140228356	2	3	111	1	0	0	0	0	0	0	0	1	11531	755	27	4		4	PCDHA9	5	140228356	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	14112	140228356	40686904	44	33999										
PCDHB11	56125	broad.mit.edu	37	chr5	140580672	140580672	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caacacaactgtgttggtctCtgacgtcaatgacaacgccc	8	13	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:140580672C>G	uc003liy.2	+	1	1325	c.1325C>G	c.(1324-1326)TCT>TGT	p.S442C	PCDHB11_uc011daj.1_Missense_Mutation_p.S77C	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	442	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGTTGGTCTCTGACGTCAAT	0.572													0	0	0	0.870114	0	40	228										G	140580672	C	G	140580672	3	3	111	1	0	0	0	0	1	0	0	0	11536	913	32	1	1327	1	PCDHB11	5	140580672	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	352316	140580672	40334588	45	34000										
THG1L	54974	broad.mit.edu	37	chr5	157159883	157159883	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttcccctgtgaaggtttgctGagaagcacaactttgcaaaa	9	9	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr5:157159883G>A	uc003lxd.2	+	2	325	c.199G>A	c.(199-201)GAG>AAG	p.E67K	THG1L_uc011ddu.1_5'UTR	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45	67					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAGGTTTGCTGAGAAGCACAA	0.473													0	0	0	0.27861	0	6	81										A	157159883	G	A	157159883	3	1	111	1	0	0	0	0	1	0	0	0	15858	1291	45	1	205	1	THG1L	5	157159883	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	16579211	157159883	23755377	46	34001										
RREB1	6239	broad.mit.edu	37	chr6	7229719	7229725	+	Frame_Shift_Del	DEL	TCGGCCA	TCGGCCA	-													0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tcaagcccatctctggcgagTcggccatcgagctggcagac					rs147038452		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:7229719_7229725delTCGGCCA	uc003mxc.2	+	10	1777_1783	c.1387_1393delTCGGCCA	c.(1387-1395)TCGGCCATCfs	p.S463fs	RREB1_uc003mxb.2_Frame_Shift_Del_p.S463fs|RREB1_uc010jnx.2_Frame_Shift_Del_p.S463fs	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	463_465					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTCTGGCGAGTCGGCCATCGAGCTGGC	0.599																		103	50	---	---								-	7229725	TCGGCCA	-	7229719	7	5	111	1	0	1	0	1	0	0	0	0	13679	1667	58	0	1413	0	RREB1	6	7229719	Frame_Shift_Del	DEL	TCGGCCA	TCGA-GD-A3OQ-01A-32D-A21Z-08		7229719	163885348	47	34002										
HIST1H2BD	3017	broad.mit.edu	37	chr6	26158562	26158562	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtccatcccgacaccggcatCtcttccaaggcaatggggat	10	14	1	0	rs141600148	byFrequency	TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:26158562C>G	uc003ngr.2	+	1	214	c.165C>G	c.(163-165)ATC>ATG	p.I55M	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.I55M	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	55					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						ACACCGGCATCTCTTCCAAGG	0.562													0	0	0	0.729181	0	30	245										G	26158562	C	G	26158562	3	3	111	1	0	0	0	0	1	0	0	0	7143	903	32	1	167	1	HIST1H2BD	6	26158562	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	18928843	26158562	144956505	48	34003										
MDC1	9656	broad.mit.edu	37	chr6	30672587	30672587	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caggctggtctgtggaggtgGaaggctggagctcaggggct	20	7	2	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:30672587G>C	uc003nrg.3	-	10	4813	c.4373C>G	c.(4372-4374)TCC>TGC	p.S1458C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.S1065C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1458	Pro-rich.|Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TGTGGAGGTGGAAGGCTGGAG	0.567								Other_conserved_DNA_damage_response_genes					0	0	0	0.870114	0	41	149										C	30672587	G	C	30672587	3	2	111	1	0	0	0	0	1	0	0	0	9403	1174	41	1	1920	1	MDC1	6	30672587	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	4514025	30672587	140442480	49	34004										
IP6K3	117283	broad.mit.edu	37	chr6	33694647	33694647	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	agcgagaaggctggagtgttGaggtggggctcggacctcag	19	7	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:33694647G>C	uc010jvf.2	-	5	986	c.450C>G	c.(448-450)CTC>CTG	p.L150L	IP6K3_uc003ofb.2_Silent_p.L150L	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	150					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						CTGGAGTGTTGAGGTGGGGCT	0.647													0	0	0	0.307466	0	6	129										C	33694647	G	C	33694647	2	2	111	1	0	0	0	0	0	0	0	1	7790	1277	45	1		1	IP6K3	6	33694647	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	3022060	33694647	137420420	50	34005										
CDKN1A	1026	broad.mit.edu	37	chr6	36652057	36652058	+	Frame_Shift_Ins	INS	-	-	G													0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtcaccgagacaccactggaINSgggtgacttcgcctgggagc							TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:36652057_36652058insG	uc003omm.3	+	2	301_302	c.179_180insG	c.(178-180)GAGfs	p.E60fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E94fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E60fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E60fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	60					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						ACACCACTGGAGGGTGACTTCG	0.668									Multiple_Endocrine_Neoplasia_type_1									34	29	---	---								G	36652058	-	G	36652057	7	5	111	1	0	1	1	0	0	0	0	0	3158	304	11	0	181	0	CDKN1A	6	36652057	Frame_Shift_Ins	INS	-	TCGA-GD-A3OQ-01A-32D-A21Z-08	2957410	36652057	134463010	51	34006										
DAAM2	23500	broad.mit.edu	37	chr6	39869784	39869784	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aggccctggaagttacccggGagcgggcaataaaccggcta	14	11	0	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:39869784G>A	uc003oow.2	+	25	3334	c.3178G>A	c.(3178-3180)GAG>AAG	p.E1060K	DAAM2_uc003oox.2_Missense_Mutation_p.E1059K	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	1060					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGTTACCCGGGAGCGGGCAAT	0.612													0	0	0	0.435327	0	12	32										A	39869784	G	A	39869784	3	1	111	1	0	0	0	0	1	0	0	0	4216	1175	41	1	3269	1	DAAM2	6	39869784	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	3217727	39869784	131245283	52	34007										
ABCC10	89845	broad.mit.edu	37	chr6	43400565	43400565	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ccttgtatggggcctttggaCggtgctatctggcacttgga	14	9	1	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:43400565C>T	uc003ouy.1	+	3	1062	c.847C>T	c.(847-849)CGG>TGG	p.R283W	ABCC10_uc003ouz.1_Missense_Mutation_p.R240W|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	283						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCCTTTGGACGGTGCTATCT	0.627													0	0	0	0.184627	0	4	50										T	43400565	C	T	43400565	3	4	111	1	0	0	0	0	1	0	0	0	50	527	19	2	720	2	ABCC10	6	43400565	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	3530781	43400565	127714502	53	34008										
PLA2G7	7941	broad.mit.edu	37	chr6	46684211	46684211	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttctttatttgggatccaaaGggtgtcaaggcgatcattat	10	6	3	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:46684211G>T	uc010jzf.2	-	4	555	c.286C>A	c.(286-288)CTT>ATT	p.L96I	PLA2G7_uc010jzg.1_Missense_Mutation_p.L96I|PLA2G7_uc011dwd.1_Missense_Mutation_p.L51I|PLA2G7_uc011dwe.1_Intron	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	96					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			GGGATCCAAAGGGTGTCAAGG	0.373													1	0	2.74318e-10	0.335167	2.84478e-10	7	73										T	46684211	G	T	46684211	3	4	111	1	0	0	0	0	1	0	0	0	12009	1000	35	4	1075	4	PLA2G7	6	46684211	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	3283646	46684211	124430856	54	34009										
C6orf211	79624	broad.mit.edu	37	chr6	151779478	151779478	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tgcaggaaggcgtggaagctGaaaagaaagctatctctctc	12	8	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:151779478G>A	uc003qok.1	+	3	422	c.163G>A	c.(163-165)GAA>AAA	p.E55K	C6orf211_uc011ees.1_5'UTR	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	55							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		CGTGGAAGCTGAAAAGAAAGC	0.348													0	0	0	0.575678	0	16	155										A	151779478	G	A	151779478	3	1	111	1	0	0	0	0	1	0	0	0	2354	1291	45	1	173	1	C6orf211	6	151779478	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	105095267	151779478	19335589	55	34010										
WTAP	9589	broad.mit.edu	37	chr6	160174530	160174530	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aatggcgaagtgtcgaatgcTtatccaggagaatcaagagc	12	7	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr6:160174530T>C	uc003qsl.2	+	7	713	c.491T>C	c.(490-492)CTT>CCT	p.L164P	WTAP_uc003qso.2_Missense_Mutation_p.L45P	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	164					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TGTCGAATGCTTATCCAGGAG	0.438													0	0	0	0.639603	0	23	45										C	160174530	T	C	160174530	3	2	111	1	0	0	0	0	1	0	0	0	17406	1609	56	5	517	5	WTAP	6	160174530	Missense_Mutation	SNP	T	TCGA-GD-A3OQ-01A-32D-A21Z-08	8395052	160174530	10940537	56	34011										
EVX1	2128	broad.mit.edu	37	chr7	27285709	27285709	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	catccgccgcctccgccgccGcctcgcccttcagcggctcg	10	23	1	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:27285709G>A	uc003szd.1	+	3	1375	c.889G>A	c.(889-891)GCC>ACC	p.A297T	EVX1_uc011jzn.1_Missense_Mutation_p.A115T|EVX1_uc010kuy.1_3'UTR	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	297	Ala-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						CTCCGCCGCCGCCTCGCCCTT	0.776													0	0	0	0.184627	0	4	15										A	27285709	G	A	27285709	3	1	111	1	0	0	0	0	1	0	0	0	5294	1087	38	2	899	2	EVX1	7	27285709	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		27285709	131852954	57	34012										
CASD1	64921	broad.mit.edu	37	chr7	94163033	94163033	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gtagcagtgaagcgctttctCaatataaaatgaacatcacc	7	9	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:94163033C>T	uc003uni.3	+	7	774	c.547C>T	c.(547-549)CAA>TAA	p.Q183*	CASD1_uc003unh.2_Nonsense_Mutation_p.Q183*|CASD1_uc003unj.3_Nonsense_Mutation_p.Q183*	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	183						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AGCGCTTTCTCAATATAAAAT	0.318													0	0	0	0.520397	0	14	55										T	94163033	C	T	94163033	4	4	111	1	0	0	0	0	0	1	0	0	2664	827	29	1	573	1	CASD1	7	94163033	Nonsense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	66877324	94163033	64975630	58	34013										
RELN	5649	broad.mit.edu	37	chr7	103185777	103185777	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ggtaaaatccctggtaccatCtgaaacggacagatctggaa	10	9	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:103185777C>G	uc003vca.2	-	42	6477	c.6317G>C	c.(6316-6318)AGA>ACA	p.R2106T	RELN_uc010liz.2_Missense_Mutation_p.R2106T	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2106					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGGTACCATCTGAAACGGAC	0.453													0	0	0	0.479597	0	12	42										G	103185777	C	G	103185777	3	3	111	1	0	0	0	0	1	0	0	0	13220	913	32	1	4161	1	RELN	7	103185777	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	9022744	103185777	55952886	59	34014										
ZNF786	136051	broad.mit.edu	37	chr7	148768420	148768420	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cagcccacactctgggcactGaaagggcttctcgtccgtgt	11	14	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr7:148768420G>A	uc003wfh.2	-	4	1581	c.1444C>T	c.(1444-1446)CAG>TAG	p.Q482*	ZNF786_uc011kuk.1_Nonsense_Mutation_p.Q445*|ZNF786_uc003wfi.2_Nonsense_Mutation_p.Q396*	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	482	C2H2-type 7; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTGGGCACTGAAAGGGCTTC	0.652													0	0	0	0.150653	0	3	21										A	148768420	G	A	148768420	4	1	111	1	0	0	0	0	0	1	0	0	18155	1299	45	1	908	1	ZNF786	7	148768420	Nonsense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	45582643	148768420	10370243	60	34015										
SLC7A2	6542	broad.mit.edu	37	chr8	17422584	17422584	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cagaagaaaaatctgccattCaagcaaatgaccatcaccca	5	12	3	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr8:17422584C>T	uc011kyc.1	+	12	2075	c.1906C>T	c.(1906-1908)CAA>TAA	p.Q636*	SLC7A2_uc011kyd.1_Nonsense_Mutation_p.Q675*|SLC7A2_uc011kye.1_Nonsense_Mutation_p.Q676*|SLC7A2_uc011kyf.1_Nonsense_Mutation_p.Q636*	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	636	Cytoplasmic (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	ATCTGCCATTCAAGCAAATGA	0.428													0	0	0	0.307466	0	7	28										T	17422584	C	T	17422584	4	4	111	1	0	0	0	0	0	1	0	0	14697	827	29	1	2213	1	SLC7A2	8	17422584	Nonsense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08		17422584	128941438	61	34016										
TRIM35	23087	broad.mit.edu	37	chr8	27145409	27145409	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgtgtgagtggccctcagcGcccgagtcctggcgcacacg	14	15	1	1	rs143436239		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr8:27145409G>A	uc003xfl.1	-	6	1222	c.1140C>T	c.(1138-1140)GGC>GGT	p.G380G	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	380	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		GGCCCTCAGCGCCCGAGTCCT	0.692													0	0	0	0.500413	0	14	27										A	27145409	G	A	27145409	2	1	111	1	0	0	0	0	0	0	0	1	16506	1074	38	2		2	TRIM35	8	27145409	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	9722825	27145409	119218613	62	34017										
KCNU1	157855	broad.mit.edu	37	chr8	36766906	36766906	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ggagatgcccactcagccccGatggggcttcggaactttgt	13	12	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr8:36766906G>A	uc010lvw.2	+	21	2271	c.2184G>A	c.(2182-2184)CCG>CCA	p.P728P	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	728	Segment S9.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCAGCCCCGATGGGGCTTC	0.468													0	0	0	0.435327	0	12	286										A	36766906	G	A	36766906	2	1	111	1	0	0	0	0	0	0	0	1	8093	1045	37	1		1	KCNU1	8	36766906	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	9621497	36766906	109597116	63	34018										
TOPORS	10210	broad.mit.edu	37	chr9	32543241	32543241	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	agtaacgtgtacctgctctgAgcttgagtaagatggtcctg	12	8	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr9:32543241A>C	uc003zrb.2	-	3	1449	c.1282T>G	c.(1282-1284)TCA>GCA	p.S428A	TOPORS_uc003zrc.2_Missense_Mutation_p.S361A	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	428					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ACCTGCTCTGAGCTTGAGTAA	0.453													0	0	0	0.870114	0	77	27										C	32543241	A	C	32543241	3	2	111	1	0	0	0	0	1	0	0	0	16367	304	11	5	1859	5	TOPORS	9	32543241	Missense_Mutation	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08		32543241	108670190	64	34019										
COL27A1	85301	broad.mit.edu	37	chr9	117002529	117002529	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ggagacatcggcccccctggCgacaatggcccagaaggcat	13	14	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr9:117002529C>T	uc011lxl.1	+	20	2757	c.2757C>T	c.(2755-2757)GGC>GGT	p.G919G	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	919	Collagen-like 5.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCCCCCCTGGCGACAATGGCC	0.502													0	0	0	0.870114	0	65	24										T	117002529	C	T	117002529	2	4	111	1	0	0	0	0	0	0	0	1	3685	755	27	2		2	COL27A1	9	117002529	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	84459288	117002529	24210902	65	34020										
GDF2	2658	broad.mit.edu	37	chr10	48414152	48414152	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gggggacactgatgtccagcGtgtcgcagcccttcctgtgg	15	12	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:48414152G>A	uc001jfa.1	-	2	879	c.716C>T	c.(715-717)ACG>ATG	p.T239M		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	239					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GATGTCCAGCGTGTCGCAGCC	0.582													0	0	0	0.639603	0	24	36										A	48414152	G	A	48414152	3	1	111	1	0	0	0	0	1	0	0	0	6314	1145	40	2	577	2	GDF2	10	48414152	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		48414152	87120595	66	34021										
RUFY2	55680	broad.mit.edu	37	chr10	70166569	70166570	+	Frame_Shift_Ins	INS	-	-	A													0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cggcgtcaggcacccaggccINSaaaacctgagatgcgtcttc							TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:70166569_70166570insA	uc001job.2	-	1	377_378	c.50_51insT	c.(49-51)TTGfs	p.L17fs	RUFY2_uc001jnz.1_Intron|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Intron|RUFY2_uc001jod.1_Intron|RUFY2_uc009xpv.1_Intron|RUFY2_uc001joe.1_Intron	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	Error:Variant_position_missing_in_Q8WXA3_after_alignment						nucleus	metal ion binding			ovary(1)	1						GCACCCAGGCCAAAACCTGAGA	0.708																		31	54	---	---								A	70166570	-	A	70166569	7	5	111	1	0	1	1	0	0	0	0	0	13739	593	21	0	2059	0	RUFY2	10	70166569	Frame_Shift_Ins	INS	-	TCGA-GD-A3OQ-01A-32D-A21Z-08	21752417	70166569	65368178	67	34022										
CCAR1	55749	broad.mit.edu	37	chr10	70531073	70531074	+	Frame_Shift_Ins	INS	-	-	A													0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aggacaaaaaagaaaaggatINSaaaaaaagcaaaaaagatga					rs3205757		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:70531073_70531074insA	uc001joo.2	+	18	2528_2529	c.2409_2410insA	c.(2407-2412)GATAAAfs	p.D803fs	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Frame_Shift_Ins_p.D608fs|CCAR1_uc009xpx.1_Frame_Shift_Ins_p.D777fs|CCAR1_uc001jon.1_Frame_Shift_Ins_p.D749fs|CCAR1_uc010qiz.1_Frame_Shift_Ins_p.D788fs|CCAR1_uc010qja.1_Frame_Shift_Ins_p.D788fs|CCAR1_uc010qjb.1_RNA	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	803_804	Glu-rich.				apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						aagaaaaggataaaaaaagcaa	0.134																		9	26	---	---								A	70531074	-	A	70531073	7	5	111	1	0	1	1	0	0	0	0	0	2730	1403	49	0	2475	0	CCAR1	10	70531073	Frame_Shift_Ins	INS	-	TCGA-GD-A3OQ-01A-32D-A21Z-08	364504	70531073	65003674	68	34023										
PPP3CB	5532	broad.mit.edu	37	chr10	75214224	75214224	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	atcatcagagcaaatactcaGaacatttaccaacatttctg	4	10	4	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:75214224G>C	uc001jue.2	-	10	1267	c.1132C>G	c.(1132-1134)CTG>GTG	p.L378V	PPP3CB_uc001juf.2_Missense_Mutation_p.L378V|PPP3CB_uc001jug.2_Missense_Mutation_p.L378V|PPP3CB_uc001jui.2_Missense_Mutation_p.L396V|PPP3CB_uc001juh.2_Missense_Mutation_p.L292V|PPP3CB_uc010qkj.1_Missense_Mutation_p.L6V	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	378										skin(1)	1	Prostate(51;0.0119)					CAAATACTCAGAACATTTACC	0.303													0	0	0	0.435327	0	10	110										C	75214224	G	C	75214224	3	2	111	1	0	0	0	0	1	0	0	0	12398	933	33	1	465	1	PPP3CB	10	75214224	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	4683151	75214224	60320523	69	34024										
KIF20B	9585	broad.mit.edu	37	chr10	91511157	91511157	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gcgaatgacactagaagaacAggaacaaactcaggtagaac	10	8	1	4			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:91511157A>G	uc001kgs.1	+	24	4223	c.4151A>G	c.(4150-4152)CAG>CGG	p.Q1384R	KIF20B_uc001kgr.1_Missense_Mutation_p.Q1344R|KIF20B_uc001kgt.1_Missense_Mutation_p.Q595R|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1384					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						CTAGAAGAACAGGAACAAACT	0.358													0	0	0	0.769981	0	27	223										G	91511157	A	G	91511157	3	3	111	1	0	0	0	0	1	0	0	0	8287	188	7	5	4121	5	KIF20B	10	91511157	Missense_Mutation	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08	16296933	91511157	44023590	70	34025										
UBTD1	80019	broad.mit.edu	37	chr10	99327844	99327844	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cctatgctgctgaagccaacGaccacgagctggcccaggcc	11	16	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:99327844G>A	uc001knv.1	+	2	437	c.244G>A	c.(244-246)GAC>AAC	p.D82N		NM_024954	NP_079230	Q9HAC8	UBTD1_HUMAN	ubiquitin domain containing 1	82											0		Colorectal(252;0.162)		Epithelial(162;3.04e-10)|all cancers(201;2.86e-08)		TGAAGCCAACGACCACGAGCT	0.637													0	0	0	0.870114	0	34	76										A	99327844	G	A	99327844	3	1	111	1	0	0	0	0	1	0	0	0	16904	1058	37	1	250	1	UBTD1	10	99327844	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	7816687	99327844	36206903	71	34026										
INPP5F	22876	broad.mit.edu	37	chr10	121551496	121551496	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gacctatgacctgaccaattCcgtgcagaggcagagcactg	11	12	0	4			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:121551496C>T	uc001leo.2	+	5	726	c.560C>T	c.(559-561)TCC>TTC	p.S187F	INPP5F_uc001len.3_Missense_Mutation_p.S187F	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	187	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CTGACCAATTCCGTGCAGAGG	0.507													0	0	0	0.750413	0	27	179										T	121551496	C	T	121551496	3	4	111	1	0	0	0	0	1	0	0	0	7758	855	30	1	578	1	INPP5F	10	121551496	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	22223652	121551496	13983251	72	34027										
UROS	7390	broad.mit.edu	37	chr10	127483469	127483469	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cttaatttgatcgatattgtCaccagataactcctgaatgt	6	8	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr10:127483469C>T	uc001liw.3	-	8	773	c.640G>A	c.(640-642)GAC>AAC	p.D214N	UROS_uc001liv.3_Missense_Mutation_p.D95N|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Missense_Mutation_p.D214N|UROS_uc001liy.3_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	214					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				TCGATATTGTCACCAGATAAC	0.373													0	0	0	0.335167	0	8	82										T	127483469	C	T	127483469	3	4	111	1	0	0	0	0	1	0	0	0	17027	826	29	1	165	1	UROS	10	127483469	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	5931973	127483469	8051278	73	34028										
HRAS	3265	broad.mit.edu	37	chr11	534288	534288	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gcgcactcttgcccacaccgCcggcgcccaccaccaccagc	8	23	1	0	rs104894230		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:534288C>T	uc001lpv.2	-	2	223	c.35G>A	c.(34-36)GGC>GAC	p.G12D	HRAS_uc010qvw.1_Missense_Mutation_p.G12D|HRAS_uc010qvx.1_Missense_Mutation_p.G12D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.870114	0	39	13										T	534288	C	T	534288	3	4	111	1	0	0	0	0	1	0	0	0	7348	739	26	2	617	2	HRAS	11	534288	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08		534288	134472228	74	34029										
OSBPL5	114879	broad.mit.edu	37	chr11	3147784	3147784	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ccgttgggctccatgtccttCcctgcaagagagcagtggga	13	12	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:3147784C>T	uc001lxk.2	-	3	296	c.138G>A	c.(136-138)GGG>GGA	p.G46G	OSBPL5_uc010qxq.1_5'UTR|OSBPL5_uc009ydw.2_Silent_p.G46G|OSBPL5_uc001lxl.2_Silent_p.G46G|OSBPL5_uc009ydx.2_Silent_p.G70G|OSBPL5_uc001lxm.1_RNA	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	46					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCATGTCCTTCCCTGCAAGAG	0.667													0	0	0	0.184627	0	4	26										T	3147784	C	T	3147784	2	4	111	1	0	0	0	0	0	0	0	1	11280	869	30	1		1	OSBPL5	11	3147784	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	2613496	3147784	131858732	75	34030										
DKK3	27122	broad.mit.edu	37	chr11	12030017	12030017	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cctcctcctgcgggtagctgAgagccgggccgggcttgact	15	14	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:12030017A>T	uc001mju.2	-	1	170	c.113T>A	c.(112-114)CTC>CAC	p.L38H	DKK3_uc010rcf.1_Missense_Mutation_p.L38H|DKK3_uc001mjv.2_Missense_Mutation_p.L38H|DKK3_uc001mjw.2_Missense_Mutation_p.L38H|DKK3_uc010rcg.1_Missense_Mutation_p.L38H|DKK3_uc001mjx.2_Missense_Mutation_p.L38H	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	38	O-glycosylated at one site.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		CGGGTAGCTGAGAGCCGGGCC	0.701													0	0	0	0.779181	0	30	5										T	12030017	A	T	12030017	3	4	111	1	0	0	0	0	1	0	0	0	4546	304	11	5	967	5	DKK3	11	12030017	Missense_Mutation	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08	8882233	12030017	122976499	76	34031										
TEAD1	7003	broad.mit.edu	37	chr11	12946588	12946588	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cctttgggaagcaagtagtaGaaaaagtagaggtaagttgg	14	3	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:12946588G>C	uc001mkj.3	+	11	1623	c.958G>C	c.(958-960)GAA>CAA	p.E320Q	TEAD1_uc001mkk.3_Missense_Mutation_p.E239Q|TEAD1_uc009ygl.2_Missense_Mutation_p.E156Q	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	335	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GCAAGTAGTAGAAAAAGTAGA	0.433													0	0	0	0.115264	0	3	59										C	12946588	G	C	12946588	3	2	111	1	0	0	0	0	1	0	0	0	15735	943	33	1	1037	1	TEAD1	11	12946588	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	916571	12946588	122059928	77	34032										
KCNC1	3746	broad.mit.edu	37	chr11	17793941	17793941	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ccatcgccatgcccgtgcccGtcatcgtgaacaatttcggg	10	15	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:17793941G>A	uc001mnk.3	+	2	1355	c.1300G>A	c.(1300-1302)GTC>ATC	p.V434I	KCNC1_uc009yhc.1_Missense_Mutation_p.V434I	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	434	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						GCCCGTGCCCGTCATCGTGAA	0.577													0	0	0	0.539581	0	15	86										A	17793941	G	A	17793941	3	1	111	1	0	0	0	0	1	0	0	0	8014	1145	40	2	1306	2	KCNC1	11	17793941	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	4847353	17793941	117212575	78	34033										
SPRYD5	84767	broad.mit.edu	37	chr11	55658785	55658785	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gcaaatattattgggaggttCatatgggggactcttggaat	13	4	2	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:55658785C>T	uc010rip.1	+	7	1128	c.1036C>T	c.(1036-1038)CAT>TAT	p.H346Y	SPRYD5_uc010riq.1_Missense_Mutation_p.H203Y	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	346	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TTGGGAGGTTCATATGGGGGA	0.428													0	0	0	0.411799	0	12	96										T	55658785	C	T	55658785	3	4	111	1	0	0	0	0	1	0	0	0	15110	826	29	1	1058	1	SPRYD5	11	55658785	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	37864844	55658785	79347731	79	34034										
PCNXL3	399909	broad.mit.edu	37	chr11	65403111	65403111	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	agaacgccaagcaggcgcttCgcaacatgatcaactcctcc	8	15	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr11:65403111C>T	uc001oey.2	+	32	5296	c.5296C>T	c.(5296-5298)CGC>TGC	p.R1766C	PCNXL3_uc001oez.2_Missense_Mutation_p.R653C	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1766						integral to membrane					0						GCAGGCGCTTCGCAACATGAT	0.677													0	0	0	0.307466	0	8	21										T	65403111	C	T	65403111	3	4	111	1	0	0	0	0	1	0	0	0	11593	884	31	1	5422	1	PCNXL3	11	65403111	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	9744326	65403111	69603405	80	34035										
ABCC9	10060	broad.mit.edu	37	chr12	21958155	21958155	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aaagaggccattcttgtgggCgagcaaatttgggacagtat	13	6	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:21958155C>T	uc001rfi.1	-	38	4623	c.4603G>A	c.(4603-4605)GCC>ACC	p.A1535T	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.A1499T|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1535	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTCTTGTGGGCGAGCAAATTT	0.438													0	0	0	0.335167	0	8	48										T	21958155	C	T	21958155	3	4	111	1	0	0	0	0	1	0	0	0	59	768	27	2	192	2	ABCC9	12	21958155	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08		21958155	111893740	81	34036										
SOX5	6660	broad.mit.edu	37	chr12	23699264	23699264	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	acaaaccatcagaatctccaCtcagattgaaatccatcatt	3	12	4	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:23699264C>G	uc001rfw.2	-	12	1685	c.1583G>C	c.(1582-1584)AGT>ACT	p.S528T	SOX5_uc001rfx.2_Missense_Mutation_p.S515T|SOX5_uc001rfy.2_Missense_Mutation_p.S407T|SOX5_uc001rfv.2_Missense_Mutation_p.S142T|SOX5_uc010siv.1_Missense_Mutation_p.S515T|SOX5_uc010siw.1_Intron|SOX5_uc001rfz.1_Missense_Mutation_p.S480T	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	528					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						AGAATCTCCACTCAGATTGAA	0.343													0	0	0	0.27861	0	7	109										G	23699264	C	G	23699264	3	3	111	1	0	0	0	0	1	0	0	0	14954	565	20	4	724	4	SOX5	12	23699264	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	1741109	23699264	110152631	82	34037										
ERBB3	2065	broad.mit.edu	37	chr12	56478854	56478854	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	taccattgcccaacctccgcGtggtgcgagggacccaggtc	12	15	0	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:56478854G>A	uc001sjh.2	+	3	503	c.310G>A	c.(310-312)GTG>ATG	p.V104M	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45M|ERBB3_uc001sjg.2_Missense_Mutation_p.V104M	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517													0	0	0	0.870114	0	63	106										A	56478854	G	A	56478854	3	1	111	1	0	0	0	0	1	0	0	0	5208	1145	40	2	320	2	ERBB3	12	56478854	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	32779590	56478854	77373041	83	34038										
ACSS3	79611	broad.mit.edu	37	chr12	81568654	81568654	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ccttgtttacagcaccaactGcaattagagcaatccgtcaa	6	12	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:81568654G>A	uc001szl.1	+	8	1277	c.1186G>A	c.(1186-1188)GCA>ACA	p.A396T	ACSS3_uc001szm.1_Missense_Mutation_p.A395T|ACSS3_uc001szn.1_Missense_Mutation_p.A78T	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	396						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AGCACCAACTGCAATTAGAGC	0.512													0	0	0	0.435327	0	14	46										A	81568654	G	A	81568654	3	1	111	1	0	0	0	0	1	0	0	0	190	1319	46	2	1216	2	ACSS3	12	81568654	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	25089800	81568654	52283241	84	34039										
DDX51	317781	broad.mit.edu	37	chr12	132624237	132624237	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	taccgaggaaccagcggctgCagcagcttgctggagagctc	14	12	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr12:132624237C>T	uc001ujy.3	-	14	1956	c.1917G>A	c.(1915-1917)CTG>CTA	p.L639L		NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	639	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		CCAGCGGCTGCAGCAGCTTGC	0.612													0	0	0	0.115264	0	3	30										T	132624237	C	T	132624237	2	4	111	1	0	0	0	0	0	0	0	1	4369	697	25	2		2	DDX51	12	132624237	Silent	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	51055583	132624237	1227658	85	34040										
SLC7A7	9056	broad.mit.edu	37	chr14	23244697	23244697	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tgtgaaccgctcaacatggaTcatgcagatggcatcaggga	12	9	3	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:23244697T>C	uc001wgr.3	-	7	1189	c.1051A>G	c.(1051-1053)ATC>GTC	p.I351V	SLC7A7_uc001wgs.3_Missense_Mutation_p.I351V|SLC7A7_uc001wgt.3_Missense_Mutation_p.I351V|SLC7A7_uc001wgu.3_Missense_Mutation_p.I351V|SLC7A7_uc001wgv.3_Missense_Mutation_p.I351V	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	351					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		TCAACATGGATCATGCAGATG	0.473													0	0	0	0.608945	0	20	107										C	23244697	T	C	23244697	3	2	111	1	0	0	0	0	1	0	0	0	14703	1435	50	5	500	5	SLC7A7	14	23244697	Missense_Mutation	SNP	T	TCGA-GD-A3OQ-01A-32D-A21Z-08		23244697	84104843	86	34041										
ARHGAP5	394	broad.mit.edu	37	chr14	32563175	32563175	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cccattgatacaattttcaaAcagaagggctattctgatga	7	8	2	4			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:32563175A>G	uc001wrl.2	+	2	3539	c.3300A>G	c.(3298-3300)AAA>AAG	p.K1100K	ARHGAP5_uc001wrm.2_Silent_p.K1100K|ARHGAP5_uc001wrn.2_Silent_p.K1100K|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1100					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CAATTTTCAAACAGAAGGGCT	0.383													0	0	0	0.788014	0	30	57										G	32563175	A	G	32563175	2	3	111	1	0	0	0	0	0	0	0	1	886	40	2	5		5	ARHGAP5	14	32563175	Silent	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08	9318478	32563175	74786365	87	34042										
ARF6	382	broad.mit.edu	37	chr14	50360895	50360895	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgacccggattcgggacagGaactggtatgtgcagccctc	13	12	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:50360895G>A	uc001wxg.3	+	2	1062	c.441G>A	c.(439-441)AGG>AGA	p.R147R		NM_001663	NP_001654	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	147					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding				0	all_epithelial(31;0.000822)|Breast(41;0.0117)					TTCGGGACAGGAACTGGTATG	0.542													0	0	0	0.307466	0	6	44										A	50360895	G	A	50360895	2	1	111	1	0	0	0	0	0	0	0	1	848	1165	41	1		1	ARF6	14	50360895	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	17797720	50360895	56988645	88	34043										
KCNH5	27133	broad.mit.edu	37	chr14	63175164	63175164	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cttcacatcactgatcttacGaaagatgatctgtggaacgg	9	9	4	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:63175164G>A	uc001xfx.2	-	11	2080	c.2029C>T	c.(2029-2031)CGT>TGT	p.R677C	KCNH5_uc001xfy.2_Missense_Mutation_p.S611L	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	677	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CTGATCTTACGAAAGATGATC	0.458													0	0	0	0.115264	0	3	62										A	63175164	G	A	63175164	3	1	111	1	0	0	0	0	1	0	0	0	8035	1059	37	1	941	1	KCNH5	14	63175164	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	12814269	63175164	44174376	89	34044										
MAP3K9	4293	broad.mit.edu	37	chr14	71199958	71199958	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tccatcactggaggggccatCgccatcctctccacgaggga	11	15	2	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:71199958C>T	uc001xmm.2	-	11	2128	c.2128G>A	c.(2128-2130)GAT>AAT	p.D710N	MAP3K9_uc010ttk.1_Missense_Mutation_p.D438N|MAP3K9_uc001xmk.2_Missense_Mutation_p.D443N|MAP3K9_uc001xml.2_Missense_Mutation_p.D724N	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	710					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GAGGGGCCATCGCCATCCTCT	0.433													0	0	0	0.361761	0	6	75										T	71199958	C	T	71199958	3	4	111	1	0	0	0	0	1	0	0	0	9257	884	31	1	1194	1	MAP3K9	14	71199958	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	8024794	71199958	36149582	90	34045										
EIF2B2	8892	broad.mit.edu	37	chr14	75470268	75470268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctatagactccatggacgcaGcgacgagagtgatcagcagg	13	10	1	3	rs17849324		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:75470268G>A	uc001xrc.1	+	3	381	c.299G>A	c.(298-300)AGC>AAC	p.S100N		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	100				RLHGRSD -> DSMDAAT (in Ref. 2; AAC42002).	cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		CATGGACGCAGCGACGAGAGT	0.527													0	0	0	0.834066	0	30	73										A	75470268	G	A	75470268	3	1	111	1	0	0	0	0	1	0	0	0	5001	971	34	2	309	2	EIF2B2	14	75470268	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	4270310	75470268	31879272	91	34046										
SPTLC2	9517	broad.mit.edu	37	chr14	78023407	78023407	+	Silent	SNP	G	G	A													0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tatattccttccacaaggatGagaattttcttccagggcct							TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:78023407G>A	uc001xub.2	-	7	1121	c.933C>T	c.(931-933)CTC>CTT	p.L311L		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	311						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CCACAAGGATGAGAATTTTCT	0.393													0	0	0	0.27861	0	5	60										A	78023407	G	A	78023407	2	1	111	1	0	0	0	0	0	0	0	1	15123	1277	45	1		1	SPTLC2	14	78023407	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	2553139	78023407	29326133	92	34047	175	2								
SPTLC2	9517	broad.mit.edu	37	chr14	78023409	78023409	+	Missense_Mutation	SNP	G	G	A													0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tattccttccacaaggatgaGaattttcttccagggccttc							TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:78023409G>A	uc001xub.2	-	7	1119	c.931C>T	c.(931-933)CTC>TTC	p.L311F		NM_004863	NP_004854	O15270	SPTC2_HUMAN	serine palmitoyltransferase, long chain base	311						integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			upper_aerodigestive_tract(1)|ovary(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0346)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	ACAAGGATGAGAATTTTCTTC	0.393													0	0	0	0.248553	0	4	59										A	78023409	G	A	78023409	3	1	111	1	0	0	0	0	1	0	0	0	15123	942	33	1	781	1	SPTLC2	14	78023409	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	2	78023409	29326131	93	34048	175	2								
KIF26A	26153	broad.mit.edu	37	chr14	104618365	104618365	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tcctcaggatccttgcctctCtgccctgcttctcgacaagc	7	17	3	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr14:104618365C>T	uc001yos.3	+	3	302	c.302C>T	c.(301-303)TCT>TTT	p.S101F		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	101					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCTTGCCTCTCTGCCCTGCTT	0.672													0	0	0	0.27861	0	6	53										T	104618365	C	T	104618365	3	4	111	1	0	0	0	0	1	0	0	0	8294	913	32	1	312	1	KIF26A	14	104618365	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	26594956	104618365	2731175	94	34049										
C15orf55	256646	broad.mit.edu	37	chr15	34647806	34647806	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgttgaggatgaagatgggGatgggcggcttcggccctca	17	8	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:34647806G>A	uc001zif.2	+	7	1668	c.1513G>A	c.(1513-1515)GAT>AAT	p.D505N	C15orf55_uc010ucc.1_Missense_Mutation_p.D533N|C15orf55_uc010ucd.1_Missense_Mutation_p.D523N	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	505						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		TGAAGATGGGGATGGGCGGCT	0.582			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.335167	0	8	69										A	34647806	G	A	34647806	3	1	111	1	0	0	0	0	1	0	0	0	1803	1174	41	1	1539	1	C15orf55	15	34647806	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		34647806	67883586	95	34050										
C15orf55	256646	broad.mit.edu	37	chr15	34648553	34648553	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aagttgagaagtgtgtaactGagtatcaggaaggctgccag	14	5	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:34648553G>T	uc001zif.2	+	7	2415	c.2260G>T	c.(2260-2262)GAG>TAG	p.E754*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.E782*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.E772*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	754						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GTGTGTAACTGAGTATCAGGA	0.532			T	BRD3|BRD4	lethal midline carcinoma								1	0	0.00307968	0.27861	0.00314712	7	79										T	34648553	G	T	34648553	4	4	111	1	0	0	0	0	0	1	0	0	1803	1291	45	3	2286	3	C15orf55	15	34648553	Nonsense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	747	34648553	67882839	96	34051										
VPS13C	54832	broad.mit.edu	37	chr15	62228840	62228840	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aaacatcaacttttctcactCttacagtctcctgcacagac	3	14	4	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:62228840C>G	uc002agz.2	-	48	5785	c.5711G>C	c.(5710-5712)AGA>ACA	p.R1904T	VPS13C_uc002aha.2_Missense_Mutation_p.R1861T|VPS13C_uc002ahb.1_Missense_Mutation_p.R1904T|VPS13C_uc002ahc.1_Missense_Mutation_p.R1861T	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1904					protein localization					ovary(2)	2						TTTTCTCACTCTTACAGTCTC	0.348													0	0	0	0.335167	0	8	48										G	62228840	C	G	62228840	3	3	111	1	0	0	0	0	1	0	0	0	17188	913	32	1	5730	1	VPS13C	15	62228840	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	27580287	62228840	40302552	97	34052										
C15orf32	145858	broad.mit.edu	37	chr15	93015655	93015655	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gatgccaaagctcacgagtgGatggtttgatgctgaagcca	13	8	1	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr15:93015655G>C	uc002brc.1	+	1	749	c.277G>C	c.(277-279)GAT>CAT	p.D93H	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	93										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			ctcacgagtggATGGTTTGAT	0.279													0	0	0	0.479597	0	12	63										C	93015655	G	C	93015655	3	2	111	1	0	0	0	0	1	0	0	0	1790	1174	41	1	279	1	C15orf32	15	93015655	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	30786815	93015655	9515737	98	34053										
UQCRC2	7385	broad.mit.edu	37	chr16	21968590	21968590	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caaagttgcccccaaagttaAagccacagctgcgcctgcag	9	14	0	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr16:21968590A>C	uc002djx.2	+	2	204	c.68A>C	c.(67-69)AAA>ACA	p.K23T	UQCRC2_uc002djy.2_Missense_Mutation_p.K23T|UQCRC2_uc010bxa.2_RNA	NM_003366	NP_003357	P22695	QCR2_HUMAN	ubiquinol-cytochrome c reductase core protein II	23					aerobic respiration|oxidative phosphorylation|proteolysis|respiratory electron transport chain|transport		metalloendopeptidase activity|zinc ion binding			large_intestine(2)	2				GBM - Glioblastoma multiforme(48;0.0264)		CCCAAAGTTAAAGCCACAGCT	0.448													0	0	0	0.779181	0	26	33										C	21968590	A	C	21968590	3	2	111	1	0	0	0	0	1	0	0	0	17017	14	1	5	74	5	UQCRC2	16	21968590	Missense_Mutation	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08		21968590	68386163	99	34054										
CMIP	80790	broad.mit.edu	37	chr16	81712168	81712168	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	agccccgcctgcagcaccatGagcatcgagctgggccccca	11	18	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr16:81712168G>A	uc002fgp.2	+	10	1395	c.1323G>A	c.(1321-1323)ATG>ATA	p.M441I	CMIP_uc002fgq.1_Missense_Mutation_p.M347I|CMIP_uc010vnq.1_Missense_Mutation_p.M254I|CMIP_uc002fgr.1_Missense_Mutation_p.M288I	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	407						cytoplasm|nucleus					0						GCAGCACCATGAGCATCGAGC	0.572													0	0	0	0.479597	0	13	17										A	81712168	G	A	81712168	3	1	111	1	0	0	0	0	1	0	0	0	3578	1290	45	1	1383	1	CMIP	16	81712168	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	59743578	81712168	8642585	100	34055										
ACAP1	9744	broad.mit.edu	37	chr17	7240683	7240683	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cagaattggagacccgtctgGaaaaggtgaccctgacatgg	13	9	1	4			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:7240683G>C	uc002ggd.2	+	2	312	c.106G>C	c.(106-108)GAA>CAA	p.E36Q		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	36	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						GACCCGTCTGGAAAAGGTGAC	0.557													0	0	0	0.115264	0	3	107										C	7240683	G	C	7240683	3	2	111	1	0	0	0	0	1	0	0	0	118	1175	41	1	112	1	ACAP1	17	7240683	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		7240683	73954527	101	34056										
CRLF3	51379	broad.mit.edu	37	chr17	29119551	29119551	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tccgaagtgctatatttcttCgactgctcagactgtacccc	7	13	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:29119551C>T	uc002hfr.3	-	6	975	c.866G>A	c.(865-867)CGA>CAA	p.R289Q	CRLF3_uc010wbr.1_Missense_Mutation_p.R173Q	NM_015986	NP_057070	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	289					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm					0		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TATATTTCTTCGACTGCTCAG	0.418													0	0	0	0.870114	0	41	141										T	29119551	C	T	29119551	3	4	111	1	0	0	0	0	1	0	0	0	3888	884	31	1	474	1	CRLF3	17	29119551	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	21878868	29119551	52075659	102	34057										
PEX12	5193	broad.mit.edu	37	chr17	33903110	33903110	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caccagtcaaggaactgcaaGaagaatacacccacagaaag	8	11	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:33903110G>A	uc002hjp.2	-	3	1387	c.771C>T	c.(769-771)TTC>TTT	p.F257F		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	257	Helical; (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGAACTGCAAGAAGAATACAC	0.468													0	0	0	0.812448	0	37	68										A	33903110	G	A	33903110	2	1	111	1	0	0	0	0	0	0	0	1	11740	933	33	1		1	PEX12	17	33903110	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	4783559	33903110	47292100	103	34058										
CDK12	51755	broad.mit.edu	37	chr17	37687082	37687082	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cttgagaccaatggagtactCcacccgaccccgtccaaaca	7	16	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:37687082C>T	uc010cvv.2	+	14	4572	c.3986C>T	c.(3985-3987)TCC>TTC	p.S1329F	CDK12_uc002hrw.3_Missense_Mutation_p.S1320F	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1329					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						ATGGAGTACTCCACCCGACCC	0.562										TCGA Ovarian(9;0.13)			0	0	0	0.870114	0	50	62										T	37687082	C	T	37687082	3	4	111	1	0	0	0	0	1	0	0	0	3128	855	30	1	4040	1	CDK12	17	37687082	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	3783972	37687082	43508128	104	34059										
TBKBP1	9755	broad.mit.edu	37	chr17	45787901	45787901	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gggctccgacatccgcagctGccccctctgccagctgggtt	12	17	1	0			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:45787901G>A	uc002ilu.2	+	9	2606	c.1757G>A	c.(1756-1758)TGC>TAC	p.C586Y		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	586					innate immune response						0						ATCCGCAGCTGCCCCCTCTGC	0.602													0	0	0	0.150653	0	4	65										A	45787901	G	A	45787901	3	1	111	1	0	0	0	0	1	0	0	0	15635	1319	46	2	1791	2	TBKBP1	17	45787901	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	8100819	45787901	35407309	105	34060										
CACNA1G	8913	broad.mit.edu	37	chr17	48699087	48699087	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tgtctgaaccgtcctgctctCtagctctgacggatgactct	9	13	4	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr17:48699087C>G	uc002irk.1	+	35	6364	c.5992C>G	c.(5992-5994)CTA>GTA	p.L1998V	CACNA1G_uc002irj.1_Intron|CACNA1G_uc002irl.1_Intron|CACNA1G_uc002irm.1_Intron|CACNA1G_uc002irn.1_Intron|CACNA1G_uc002iro.1_Intron|CACNA1G_uc002irp.1_Intron|CACNA1G_uc002irq.1_Missense_Mutation_p.L1975V|CACNA1G_uc002irr.1_Intron|CACNA1G_uc002irs.1_Intron|CACNA1G_uc002irt.1_Intron|CACNA1G_uc002irv.1_Intron|CACNA1G_uc002irw.1_Missense_Mutation_p.L1927V|CACNA1G_uc002iru.1_Missense_Mutation_p.L1964V|CACNA1G_uc002irx.1_Intron|CACNA1G_uc002iry.1_Intron|CACNA1G_uc002irz.1_Intron|CACNA1G_uc002isa.1_Intron|CACNA1G_uc002isb.1_Intron|CACNA1G_uc002isc.1_Missense_Mutation_p.L1900V|CACNA1G_uc002isd.1_Intron|CACNA1G_uc002ise.1_Intron|CACNA1G_uc002isf.1_Intron|CACNA1G_uc002isg.1_Intron|CACNA1G_uc002ish.1_Intron|CACNA1G_uc002isi.1_Intron	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1998	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GTCCTGCTCTCTAGCTCTGAC	0.522													0	0	0	0.307466	0	6	54										G	48699087	C	G	48699087	3	3	111	1	0	0	0	0	1	0	0	0	2544	912	32	1	6397	1	CACNA1G	17	48699087	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	2911186	48699087	32496123	106	34061										
WDR7	23335	broad.mit.edu	37	chr18	54547217	54547217	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aatgaaaaaaatttctacatCttacgaggaaagacggaagc	8	6	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr18:54547217C>G	uc002lgk.1	+	21	3558	c.3347C>G	c.(3346-3348)TCT>TGT	p.S1116C	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.S1083C	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1116										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		ATTTCTACATCTTACGAGGAA	0.358													0	0	0	0.217242	0	5	59										G	54547217	C	G	54547217	3	3	111	1	0	0	0	0	1	0	0	0	17317	913	32	1	3425	1	WDR7	18	54547217	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08		54547217	23530031	107	34062										
PCSK4	54760	broad.mit.edu	37	chr19	1487828	1487828	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cggggctgggggtccgggtcGtagtcattgaagtcatagct	17	8	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:1487828G>A	uc002ltb.1	-	5	611	c.549C>T	c.(547-549)TAC>TAT	p.Y183Y	PCSK4_uc002lta.2_Missense_Mutation_p.T25M	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	183	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTCCGGGTCGTAGTCATTGA	0.692													0	0	0	0.150653	0	3	3										A	1487828	G	A	1487828	2	1	111	1	0	0	0	0	0	0	0	1	11602	1140	40	2		2	PCSK4	19	1487828	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		1487828	57641155	108	34063										
SCAMP4	113178	broad.mit.edu	37	chr19	1924163	1924163	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cagaaggcacagacggagtgGaacacgggcacttggcggaa	16	9	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:1924163G>C	uc002luj.2	+	7	677	c.570G>C	c.(568-570)TGG>TGC	p.W190C	SCAMP4_uc002luk.2_Missense_Mutation_p.W156C|SCAMP4_uc010dss.2_Missense_Mutation_p.W146C	NM_079834	NP_524558	Q969E2	SCAM4_HUMAN	secretory carrier membrane protein 4	190	Cytoplasmic (Potential).				protein transport	integral to membrane					0		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGACGGAGTGGAACACGGGCA	0.612													0	0	0	0.150653	0	4	26										C	1924163	G	C	1924163	3	2	111	1	0	0	0	0	1	0	0	0	13873	1183	41	1	592	1	SCAMP4	19	1924163	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	436335	1924163	57204820	109	34064										
CYP4F2	8529	broad.mit.edu	37	chr19	16008382	16008382	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cagccaaggggatgctgccaCtggccagaggcccagccagg	15	14	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:16008382C>G	uc002nbs.1	-	2	90	c.40G>C	c.(40-42)GTG>CTG	p.V14L	CYP4F2_uc010xot.1_Intron|CYP4F2_uc010xou.1_5'UTR	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	14					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GATGCTGCCACTGGCCAGAGG	0.672													0	0	0	0.38729	0	11	46										G	16008382	C	G	16008382	3	3	111	1	0	0	0	0	1	0	0	0	4188	565	20	4	1570	4	CYP4F2	19	16008382	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	14084219	16008382	43120601	110	34065										
ACTN4	81	broad.mit.edu	37	chr19	39200089	39200089	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aagtggctgagaaatacctcGacatccccaagatgctggat	10	10	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:39200089G>A	uc002oja.1	+	7	765	c.706G>A	c.(706-708)GAC>AAC	p.D236N	ACTN4_uc010egc.1_Missense_Mutation_p.D236N	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	236	Actin-binding.|CH 2.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GAAATACCTCGACATCCCCAA	0.557													0	0	0	0.592651	0	17	81										A	39200089	G	A	39200089	3	1	111	1	0	0	0	0	1	0	0	0	207	1058	37	1	732	1	ACTN4	19	39200089	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	23191707	39200089	19928894	111	34066										
FBXO27	126433	broad.mit.edu	37	chr19	39516171	39516171	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	acaaagcggacgcccatcttGatgttggagaacacgtgggt	13	9	1	2	rs151102214		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:39516171G>C	uc002okh.2	-	6	814	c.732C>G	c.(730-732)ATC>ATG	p.I244M		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	244	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CGCCCATCTTGATGTTGGAGA	0.572													0	0	0	0.115264	0	3	52										C	39516171	G	C	39516171	3	2	111	1	0	0	0	0	1	0	0	0	5737	1280	45	1	123	1	FBXO27	19	39516171	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	316082	39516171	19612812	112	34067										
ERCC2	2068	broad.mit.edu	37	chr19	45854898	45854898	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ccgccccactcagagctgctGagcaatctgctctatcctct	7	17	4	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:45854898G>C	uc002pbj.2	-	23	2319	c.2272C>G	c.(2272-2274)CAG>GAG	p.Q758E	ERCC2_uc002pbh.2_Missense_Mutation_p.Q321E|ERCC2_uc002pbi.2_Missense_Mutation_p.Q451E|ERCC2_uc010ejz.2_Missense_Mutation_p.Q680E	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	758					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CAGAGCTGCTGAGCAATCTGC	0.592			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.870114	0	39	283										C	45854898	G	C	45854898	3	2	111	1	0	0	0	0	1	0	0	0	5213	1299	45	1	14	1	ERCC2	19	45854898	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	6338727	45854898	13274085	113	34068										
ZNF808	388558	broad.mit.edu	37	chr19	53056856	53056856	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gaagtacacatgagagaaaaAtctttcccatgtaatgagag	9	6	1	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:53056856A>G	uc010epq.1	+	5	864	c.687A>G	c.(685-687)AAA>AAG	p.K229K	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TGAGAGAAAAATCTTTCCCAT	0.373													0	0	0	0.150653	0	4	229										G	53056856	A	G	53056856	2	3	111	1	0	0	0	0	0	0	0	1	18170	98	4	5		5	ZNF808	19	53056856	Silent	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08	7201958	53056856	6072127	114	34069										
VN1R4	317703	broad.mit.edu	37	chr19	53770826	53770826	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctgcacccagtgcagtaaaaGgagagataatggagaagaac	12	7	0	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:53770826G>A	uc010ydu.1	-	1	93	c.93C>T	c.(91-93)TCC>TCT	p.S31S		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	31	Cytoplasmic (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		TGCAGTAAAAGGAGAGATAAT	0.507										HNSCC(26;0.072)			0	0	0	0.217242	0	6	78										A	53770826	G	A	53770826	2	1	111	1	0	0	0	0	0	0	0	1	17177	987	35	2		2	VN1R4	19	53770826	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	713970	53770826	5358157	115	34070										
ZNF776	284309	broad.mit.edu	37	chr19	58265941	58265941	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctcattcgacatcagcagatTcactctggagaaaggccaca	8	12	4	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr19:58265941T>C	uc002qpx.2	+	3	1666	c.1443T>C	c.(1441-1443)ATT>ATC	p.I481I	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Silent_p.I481I	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	481	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		ATCAGCAGATTCACTCTGGAG	0.448													0	0	0	0.184627	0	3	111										C	58265941	T	C	58265941	2	2	111	1	0	0	0	0	0	0	0	1	18146	1771	62	5		5	ZNF776	19	58265941	Silent	SNP	T	TCGA-GD-A3OQ-01A-32D-A21Z-08	4495115	58265941	863042	116	34071										
RAE1	8480	broad.mit.edu	37	chr20	55929795	55929795	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aagtaacatcatctcctgatGatagcattggttgtctgtct	8	8	4	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr20:55929795G>A	uc002xyg.2	+	3	459	c.118G>A	c.(118-120)GAT>AAT	p.D40N	RAE1_uc010gis.1_Missense_Mutation_p.M1I|RAE1_uc010git.1_Missense_Mutation_p.D40N|RAE1_uc002xyh.2_Missense_Mutation_p.D40N|RAE1_uc002xyi.2_Missense_Mutation_p.D40N	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	40					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			ATCTCCTGATGATAGCATTGG	0.398													0	0	0	0.411799	0	9	89										A	55929795	G	A	55929795	3	1	111	1	0	0	0	0	1	0	0	0	12998	1290	45	1	124	1	RAE1	20	55929795	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		55929795	7095725	117	34072										
CDH4	1002	broad.mit.edu	37	chr20	60318751	60318751	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ctccgagcaggtggcgttcaCggtgactgcatgggacagcc	15	12	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr20:60318751C>T	uc002ybn.1	+	3	316	c.302C>T	c.(301-303)ACG>ATG	p.T101M	CDH4_uc002ybo.1_RNA|CDH4_uc002ybp.1_Missense_Mutation_p.T27M	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	101					adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTGGCGTTCACGGTGACTGCA	0.607													0	0	0	0.217242	0	5	12										T	60318751	C	T	60318751	3	4	111	1	0	0	0	0	1	0	0	0	3112	536	19	2	312	2	CDH4	20	60318751	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	4388956	60318751	2706769	118	34073										
AGPAT3	56894	broad.mit.edu	37	chr21	45401024	45401024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cttgggcgtctttgccagcgGatcacctctcctgatcctga	10	14	3	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr21:45401024G>A	uc002zdv.2	+	9	1220	c.998G>A	c.(997-999)GGA>GAA	p.G333E	AGPAT3_uc002zdw.2_Missense_Mutation_p.G333E|AGPAT3_uc002zdx.2_Missense_Mutation_p.G420E|AGPAT3_uc002zdy.2_Missense_Mutation_p.G271E	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	333	Helical; (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		TTTGCCAGCGGATCACCTCTC	0.572													0	0	0	0.479597	0	13	96										A	45401024	G	A	45401024	3	1	111	1	0	0	0	0	1	0	0	0	388	1174	41	1	1024	1	AGPAT3	21	45401024	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		45401024	2728871	119	34074										
HIC2	23119	broad.mit.edu	37	chr22	21800133	21800133	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	gggccgaggacaaccacctgAgcctgctggaggcgcctggt	16	13	0	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:21800133A>G	uc002zur.3	+	3	1179	c.949A>G	c.(949-951)AGC>GGC	p.S317G	HIC2_uc002zus.3_Missense_Mutation_p.S317G	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	317					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				CAACCACCTGAGCCTGCTGGA	0.657													0	0	0	0.248553	0	7	20										G	21800133	A	G	21800133	3	3	111	1	0	0	0	0	1	0	0	0	7102	304	11	5	955	5	HIC2	22	21800133	Missense_Mutation	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08		21800133	29504433	120	34075										
DEPDC5	9681	broad.mit.edu	37	chr22	32241198	32241198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	cttgaatcgcattcgcaggcGgcatcgctcggatcgcatga	12	12	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:32241198G>A	uc003als.2	+	30	3111	c.2969G>A	c.(2968-2970)CGG>CAG	p.R990Q	DEPDC5_uc011als.1_Missense_Mutation_p.R921Q|DEPDC5_uc011alu.1_Missense_Mutation_p.R999Q|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.R990Q|DEPDC5_uc003alu.2_Missense_Mutation_p.R439Q|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.R320Q|DEPDC5_uc003alw.2_Missense_Mutation_p.R288Q|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_5'UTR	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	990					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						ATTCGCAGGCGGCATCGCTCG	0.607													0	0	0	0.520397	0	16	19										A	32241198	G	A	32241198	3	1	111	1	0	0	0	0	1	0	0	0	4442	1116	39	2	3101	2	DEPDC5	22	32241198	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	10441065	32241198	19063368	121	34076										
EP300	2033	broad.mit.edu	37	chr22	41564853	41564853	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tcaagagtatggctctgactGccctccacccaaccagaggt	9	14	2	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:41564853G>A	uc003azl.3	+	25	4549	c.4154G>A	c.(4153-4155)TGC>TAC	p.C1385Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1385					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.C1385F(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGCTCTGACTGCCCTCCACCC	0.473			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.706142	0	23	143										A	41564853	G	A	41564853	3	1	111	1	0	0	0	0	1	0	0	0	5148	1319	46	2	4252	2	EP300	22	41564853	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	9323655	41564853	9739713	122	34077										
XRCC6	2547	broad.mit.edu	37	chr22	42042976	42042976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tccagaaggctctcaagcctCctccaataaagctctatcgg	7	14	2	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:42042976C>T	uc003bao.1	+	7	920	c.850C>T	c.(850-852)CCT>TCT	p.P284S	XRCC6_uc003bap.1_Missense_Mutation_p.P243S|XRCC6_uc011apc.1_Missense_Mutation_p.P234S|XRCC6_uc003baq.1_Missense_Mutation_p.P284S|XRCC6_uc003bar.1_Missense_Mutation_p.P284S|XRCC6_uc003bas.1_Missense_Mutation_p.P234S	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	284	Ku.				DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						TCTCAAGCCTCCTCCAATAAA	0.433								Direct_reversal_of_damage|NHEJ					0	0	0	0.750413	0	25	217										T	42042976	C	T	42042976	3	4	111	1	0	0	0	0	1	0	0	0	17454	855	30	1	872	1	XRCC6	22	42042976	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	478123	42042976	9261590	123	34078										
FBLN1	2192	broad.mit.edu	37	chr22	45927195	45927195	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	aggacccatatctgaatgacCgctgccgaggtgagactcgg	13	11	1	3	rs147266682		TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chr22:45927195C>A	uc003bgj.1	+	5	682	c.535C>A	c.(535-537)CGC>AGC	p.R179S	FBLN1_uc003bgg.1_Missense_Mutation_p.R179S|FBLN1_uc003bgh.2_Missense_Mutation_p.R179S|FBLN1_uc010gzz.2_Missense_Mutation_p.R217S|FBLN1_uc003bgi.1_Missense_Mutation_p.R179S	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	179	EGF-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TCTGAATGACCGCTGCCGAGG	0.398													1	0	9.80977e-26	0.796494	1.04837e-25	29	43										A	45927195	C	A	45927195	3	1	111	1	0	0	0	0	1	0	0	0	5698	652	23	4	553	4	FBLN1	22	45927195	Missense_Mutation	SNP	C	TCGA-GD-A3OQ-01A-32D-A21Z-08	3884219	45927195	5377371	124	34079										
FANCB	2187	broad.mit.edu	37	chrX	14882865	14882865	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttctttcgagtaagggcaatGagagatattcttaactggtt	10	5	2	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:14882865G>A	uc004cwg.1	-	3	1036	c.768C>T	c.(766-768)CTC>CTT	p.L256L	FANCB_uc004cwh.1_Silent_p.L256L	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	256					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TAAGGGCAATGAGAGATATTC	0.373								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.150653	0	4	50										A	14882865	G	A	14882865	2	1	111	1	0	0	0	0	0	0	0	1	5663	1277	45	1		1	FANCB	23	14882865	Silent	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08		14882865	140387695	125	34080										
NXF3	56000	broad.mit.edu	37	chrX	102334549	102334549	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	tttatattcctgctatccttGaagaacttgcagaagctgct	7	9	0	3			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:102334549G>C	uc004eju.2	-	14	1253	c.1182C>G	c.(1180-1182)TTC>TTG	p.F394L	NXF3_uc010noi.1_Missense_Mutation_p.F244L	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	394	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TGCTATCCTTGAAGAACTTGC	0.507													0	0	0	0.624587	0	17	89										C	102334549	G	C	102334549	3	2	111	1	0	0	0	0	1	0	0	0	10785	1281	45	1	437	1	NXF3	23	102334549	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	87451684	102334549	52936011	126	34081										
GUCY2F	2986	broad.mit.edu	37	chrX	108628509	108628509	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	caccactccagcaacaaccgGccctatagagtatcaggggg	10	14	1	1			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:108628509G>A	uc004eod.3	-	16	3235	c.2959C>T	c.(2959-2961)CCG>TCG	p.P987S	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	987	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						GCAACAACCGGCCCTATAGAG	0.473													0	0	0	0.870114	0	51	18										A	108628509	G	A	108628509	3	1	111	1	0	0	0	0	1	0	0	0	6898	1203	42	2	383	2	GUCY2F	23	108628509	Missense_Mutation	SNP	G	TCGA-GD-A3OQ-01A-32D-A21Z-08	6293960	108628509	46642051	127	34082										
RPL10	6134	broad.mit.edu	37	chrX	153627864	153627864	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.362204724409449	46	5.28871902395595e-13	3.13904	5.118	2.025875	0.159845651581888	0.301158473994861	31	ttttgacctggggcggaaaaAggcaaaagtggatgagtttc	14	5	0	2			TCGA-GD-A3OQ-01A-32D-A21Z-08	TCGA-GD-A3OQ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fb985b3d-b0f7-42a0-bc3c-f71d9c5f78d8	685111bf-0f7f-4b95-acdd-5704a8a553c5	g.chrX:153627864A>G	uc004fkm.2	+	4	307	c.119A>G	c.(118-120)AAG>AGG	p.K40R	uc010nuv.1_5'Flank|RPL10_uc004fko.2_Missense_Mutation_p.K40R|RPL10_uc004fkn.1_Missense_Mutation_p.K40R|RPL10_uc004fkp.1_Missense_Mutation_p.K40R|RPL10_uc004fkq.1_RNA|RPL10_uc004fkr.1_5'Flank|SNORA70_uc010nux.1_5'Flank	NM_006013	NP_006004	P27635	RL10_HUMAN	ribosomal protein L10	40					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGCGGAAAAAGGCAAAAGTG	0.522											OREG0019957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.217242	0	3	116										G	153627864	A	G	153627864	3	3	111	1	0	0	0	0	1	0	0	0	13554	72	3	5	129	5	RPL10	23	153627864	Missense_Mutation	SNP	A	TCGA-GD-A3OQ-01A-32D-A21Z-08	44999355	153627864	1642696	128	34083										
ZBTB40	9923	broad.mit.edu	37	chr1	22838486	22838486	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	agtgtaaggagtgcagtgagAccaaggattcaaagaaagag	14	4	1	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:22838486A>T	uc001bft.2	+	12	2831	c.2320A>T	c.(2320-2322)ACC>TCC	p.T774S	ZBTB40_uc001bfu.2_Missense_Mutation_p.T774S|ZBTB40_uc009vqi.1_Missense_Mutation_p.T662S|ZBTB40_uc001bfv.1_Missense_Mutation_p.T403S	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	774					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GTGCAGTGAGACCAAGGATTC	0.537													0	0	0	0.003954	0	21	21										T	22838486	A	T	22838486	3	4	112	1	0	0	0	0	1	0	0	0	17539	275	10	5	2358	5	ZBTB40	1	22838486	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08		22838486	226412135	1	34084										
OSCP1	127700	broad.mit.edu	37	chr1	36886081	36886081	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	caggtttaaaacatactcctCttcttcatcggtggtaaaga	7	9	3	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:36886081C>G	uc001cap.2	-	9	1067	c.985G>C	c.(985-987)GAG>CAG	p.E329Q	OSCP1_uc001caq.2_Missense_Mutation_p.E319Q	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	329					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						acatactcctcttcttcaTCG	0.249											OREG0013368	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	51	197										G	36886081	C	G	36886081	3	3	112	1	0	0	0	0	1	0	0	0	11286	922	32	1	196	1	OSCP1	1	36886081	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	14047595	36886081	212364540	2	34085										
ST6GALNAC3	256435	broad.mit.edu	37	chr1	76877711	76877711	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	agcctttgcaactggactgtGacctttgtgccatagtgtca	10	10	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:76877711G>A	uc001dhh.2	+	3	395	c.232G>A	c.(232-234)GAC>AAC	p.D78N	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.D78N|ST6GALNAC3_uc010orh.1_Missense_Mutation_p.D13N	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	78	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						ACTGGACTGTGACCTTTGTGC	0.413													0	0	0	0.00361	0	47	49										A	76877711	G	A	76877711	3	1	112	1	0	0	0	0	1	0	0	0	15224	1290	45	1	242	1	ST6GALNAC3	1	76877711	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	39991630	76877711	172372910	3	34086										
DPH5	51611	broad.mit.edu	37	chr1	101490988	101490988	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tctcccaggcccaacccgatGagataaagcatttcaaactt	6	13	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:101490988G>A	uc001dts.2	-	2	159	c.12C>T	c.(10-12)CTC>CTT	p.L4L	DPH5_uc001dtr.2_Silent_p.L4L|DPH5_uc001dtq.2_RNA|DPH5_uc001dtt.2_Silent_p.L4L|DPH5_uc001dtu.2_RNA|DPH5_uc001dtv.2_RNA|DPH5_uc001dtw.2_RNA|DPH5_uc001dtx.2_Silent_p.L4L|DPH5_uc001dty.2_5'UTR|DPH5_uc001dtz.2_RNA|uc001dua.2_5'Flank|uc001dub.2_5'Flank	NM_015958	NP_057042	Q9H2P9	DPH5_HUMAN	diphthine synthase isoform a	4					peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity				0		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)		CCAACCCGATGAGATAAAGCA	0.488													0	0	0	0.004007	0	15	45										A	101490988	G	A	101490988	2	1	112	1	0	0	0	0	0	0	0	1	4723	1277	45	1		1	DPH5	1	101490988	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	24613277	101490988	147759633	4	34087										
POLR3C	10623	broad.mit.edu	37	chr1	145601614	145601614	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	agcatggttcgcacaatctcGctgcttgtctgtttgaaaag	10	9	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:145601614G>A	uc001eoh.2	-	7	953	c.792C>T	c.(790-792)AGC>AGT	p.S264S	NBPF10_uc001emp.3_Intron|POLR3C_uc001eog.2_Silent_p.S277S|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Silent_p.S264S	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	264					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			GCACAATCTCGCTGCTTGTCT	0.453													0	0	0	0.001984	0	6	34										A	145601614	G	A	145601614	2	1	112	1	0	0	0	0	0	0	0	1	12230	1078	38	2		2	POLR3C	1	145601614	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	44110626	145601614	103649007	5	34088										
RPRD2	23248	broad.mit.edu	37	chr1	150444932	150444932	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aaacagcaccatacaaggaaCgggcacctcaatttcaggag	9	11	2	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:150444932C>T	uc009wlr.2	+	11	3709	c.3508C>T	c.(3508-3510)CGG>TGG	p.R1170W	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.R1144W	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1170							protein binding			ovary(1)	1						ATACAAGGAACGGGCACCTCA	0.532													0	0	0	0.00499	0	15	60										T	150444932	C	T	150444932	3	4	112	1	0	0	0	0	1	0	0	0	13617	527	19	2	3550	2	RPRD2	1	150444932	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	4843318	150444932	98805689	6	34089										
ATP8B2	57198	broad.mit.edu	37	chr1	154320946	154320946	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ccattgtgctcaccacagtcGtctgcatcatgcccgtggtt	9	14	3	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:154320946G>A	uc001fex.2	+	27	3325	c.3325G>A	c.(3325-3327)GTC>ATC	p.V1109I		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	1095	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACCACAGTCGTCTGCATCAT	0.607													0	0	0	0.010729	0	11	31										A	154320946	G	A	154320946	3	1	112	1	0	0	0	0	1	0	0	0	1195	1145	40	2	3561	2	ATP8B2	1	154320946	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	3876014	154320946	94929675	7	34090										
SPTA1	6708	broad.mit.edu	37	chr1	158650498	158650498	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctcccagtcttcacctagctCcactgatgtcgctatagcct	6	16	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:158650498C>G	uc001fst.1	-	5	752	c.553G>C	c.(553-555)GAG>CAG	p.E185Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	185	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCACCTAGCTCCACTGATGTC	0.448													0	0	0	0.005524	0	33	58										G	158650498	C	G	158650498	3	3	112	1	0	0	0	0	1	0	0	0	15115	864	30	1	6898	1	SPTA1	1	158650498	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	4329552	158650498	90600123	8	34091										
KIFAP3	22920	broad.mit.edu	37	chr1	169923248	169923248	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctccttcagaggcaattaatCcatctagaaagaaaaaaaaa	5	8	2	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:169923248C>T	uc001ggv.2	-	19	2448	c.2177G>A	c.(2176-2178)GGA>GAA	p.G726E	KIFAP3_uc010plx.1_Missense_Mutation_p.G428E	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	726					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGCAATTAATCCATCTAGAAA	0.343													0	0	0	0.007291	0	30	96										T	169923248	C	T	169923248	3	4	112	1	0	0	0	0	1	0	0	0	8311	855	30	1	209	1	KIFAP3	1	169923248	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	11272750	169923248	79327373	9	34092										
CFHR4	10877	broad.mit.edu	37	chr1	196887480	196887480	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ataatgcgaatacatcagttCtatcatttcaagcagtgtgt	7	7	4	0	rs80010185	by1000genomes	TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:196887480C>G	uc001gto.2	+	6	1009	c.940C>G	c.(940-942)CTA>GTA	p.L314V	CFHR4_uc009wyy.2_Missense_Mutation_p.L560V|CFHR4_uc001gtp.2_Missense_Mutation_p.L561V	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	314	Sushi 5.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TACATCAGTTCTATCATTTCA	0.363													0	0	0	0.00874	0	33	241										G	196887480	C	G	196887480	3	3	112	1	0	0	0	0	1	0	0	0	3287	912	32	1	962	1	CFHR4	1	196887480	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	26964232	196887480	52363141	10	34093										
CFHR2	3080	broad.mit.edu	37	chr1	196918666	196918666	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gccattttcccaagttcctaCaggggaagttttctattact	7	10	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:196918666C>T	uc001gtq.1	+	2	217	c.140C>T	c.(139-141)ACA>ATA	p.T47I	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	47	Sushi 1.					extracellular region				skin(2)|ovary(1)	3						CAAGTTCCTACAGGGGAAGTT	0.358													0	0	0	0.008291	0	11	70										T	196918666	C	T	196918666	3	4	112	1	0	0	0	0	1	0	0	0	3285	478	17	2	146	2	CFHR2	1	196918666	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	31186	196918666	52331955	11	34094										
TMEM206	55248	broad.mit.edu	37	chr1	212553312	212553312	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cctcactactcttgttcaggCggaactggaggaagaccagc	11	12	3	1	rs141387916		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:212553312C>T	uc001hjc.3	-	5	731	c.563G>A	c.(562-564)CGC>CAC	p.R188H	TMEM206_uc010pte.1_Missense_Mutation_p.R249H	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	188	Extracellular (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		CTTGTTCAGGCGGAACTGGAG	0.522													0	0	0	0.002299	0	22	90										T	212553312	C	T	212553312	3	4	112	1	0	0	0	0	1	0	0	0	16128	768	27	2	505	2	TMEM206	1	212553312	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	15634646	212553312	36697309	12	34095										
GNG4	2786	broad.mit.edu	37	chr1	235715501	235715501	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atcttcccgcacgtgagcttCacagtaggccaggaggtccg	12	13	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:235715501C>T	uc001hxe.3	-	4	590	c.136G>A	c.(136-138)GAA>AAA	p.E46K	GNG4_uc009xfz.2_Missense_Mutation_p.E46K|GNG4_uc001hxh.3_Missense_Mutation_p.E46K	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	46					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			ACGTGAGCTTCACAGTAGGCC	0.542													0	0	0	0.00361	0	82	69										T	235715501	C	T	235715501	3	4	112	1	0	0	0	0	1	0	0	0	6529	835	29	1	95	1	GNG4	1	235715501	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	23162189	235715501	13535120	13	34096										
CHML	1122	broad.mit.edu	37	chr1	241798859	241798859	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgccatacaacagtactttcTtccccaatgtcattgttttg	5	11	2	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:241798859T>G	uc001hzd.2	-	1	374	c.210A>C	c.(208-210)GAA>GAC	p.E70D	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	70					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CAGTACTTTCTTCCCCAATGT	0.418													0	0	0	0.00361	0	60	203										G	241798859	T	G	241798859	3	3	112	1	0	0	0	0	1	0	0	0	3351	1606	56	5	1764	5	CHML	1	241798859	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	6083358	241798859	7451762	14	34097										
TRIM58	25893	broad.mit.edu	37	chr1	248023982	248023982	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aggacgccttgactcaggagGccaacgtggggaaaaagact	14	9	1	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:248023982G>A	uc001ido.2	+	2	532	c.484G>A	c.(484-486)GCC>ACC	p.A162T		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	162						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GACTCAGGAGGCCAACGTGGG	0.483													0	0	0	0.008291	0	9	47										A	248023982	G	A	248023982	3	1	112	1	0	0	0	0	1	0	0	0	16528	1203	42	2	490	2	TRIM58	1	248023982	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	6225123	248023982	1226639	15	34098										
OR2T34	127068	broad.mit.edu	37	chr1	248737333	248737333	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgggaggagcaggtggccaaGgccttcctgcggccggcggc	19	12	0	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:248737333G>C	uc001iep.1	-	1	726	c.726C>G	c.(724-726)GCC>GCG	p.A242A		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGTGGCCAAGGCCTTCCTGC	0.567													0	0	0	0.008361	0	26	140										C	248737333	G	C	248737333	2	2	112	1	0	0	0	0	0	0	0	1	11025	987	35	4		4	OR2T34	1	248737333	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	713351	248737333	513288	16	34099										
BIRC6	57448	broad.mit.edu	37	chr2	32640936	32640936	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	caggacacaattacctcgctCattttgcttccacccgatat	5	14	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:32640936C>G	uc010ezu.2	+	10	2711	c.2577C>G	c.(2575-2577)CTC>CTG	p.L859L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	859					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTACCTCGCTCATTTTGCTTC	0.388													0	0	0	0.00333	0	22	26										G	32640936	C	G	32640936	2	3	112	1	0	0	0	0	0	0	0	1	1438	813	29	1		1	BIRC6	2	32640936	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		32640936	210558437	17	34100										
ANAPC1	64682	broad.mit.edu	37	chr2	112541911	112541911	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ccagcttacctgctttaaaaGatggagttctggaagaaggg	12	7	1	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:112541911G>T	uc002thi.2	-	41	5231	c.4984C>A	c.(4984-4986)CTT>ATT	p.L1662I		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1662					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						TGCTTTAAAAGATGGAGTTCT	0.438													1	0	3.80469e-20	0.009535	4.43881e-20	21	148										T	112541911	G	T	112541911	3	4	112	1	0	0	0	0	1	0	0	0	598	942	33	3	882	3	ANAPC1	2	112541911	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	79900975	112541911	130657462	18	34101										
MARCO	8685	broad.mit.edu	37	chr2	119752005	119752005	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	taatgttcagtgtcggggcaCggagagtaccctgtggagct	15	8	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:119752005C>T	uc002tln.1	+	17	1604	c.1472C>T	c.(1471-1473)ACG>ATG	p.T491M	MARCO_uc010yyf.1_Missense_Mutation_p.T413M	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	491	SRCR.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TGTCGGGGCACGGAGAGTACC	0.552													0	0	0	0.007413	0	17	60										T	119752005	C	T	119752005	3	4	112	1	0	0	0	0	1	0	0	0	9311	536	19	2	1538	2	MARCO	2	119752005	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	7210094	119752005	123447368	19	34102										
TTN	7273	broad.mit.edu	37	chr2	179404371	179404371	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctcacagagcggacttggatGtcatcatattccagtggccc	10	12	3	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:179404371G>A	uc010zfg.1	-	301	90941	c.90717C>T	c.(90715-90717)GAC>GAT	p.D30239D	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D23934D|TTN_uc010zfi.1_Silent_p.D23867D|TTN_uc010zfj.1_Silent_p.D23742D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31166							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGACTTGGATGTCATCATATT	0.507													0	0	0	0.00623	0	38	56										A	179404371	G	A	179404371	2	1	112	1	0	0	0	0	0	0	0	1	16732	1368	48	2		2	TTN	2	179404371	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	59652366	179404371	63795002	20	34103										
TTN	7273	broad.mit.edu	37	chr2	179528611	179528611	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctttctcttcgcggataaccTctttggaagcttctggcact	8	12	3	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:179528611T>G	uc010zfk.1	-	15	1369	c.821A>C	c.(820-822)GAG>GCG	p.E274A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGGATAACCTCTTTGGAAGC	0.418													0	0	0	0.003271	0	30	115										G	179528611	T	G	179528611	3	3	112	1	0	0	0	0	1	0	0	0	16732	1566	54	5		5	TTN	2	179528611	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	124240	179528611	63670762	21	34104										
ZDBF2	57683	broad.mit.edu	37	chr2	207169716	207169716	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cttggagtttgttcataaaaTtggggccagtgtgagaaaat	12	4	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:207169716T>C	uc002vbp.2	+	5	714	c.464T>C	c.(463-465)ATT>ACT	p.I155T		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	155							nucleic acid binding|zinc ion binding			ovary(3)	3						GTTCATAAAATTGGGGCCAGT	0.448													0	0	0	0.001855	0	14	10										C	207169716	T	C	207169716	3	2	112	1	0	0	0	0	1	0	0	0	17596	1493	52	5	474	5	ZDBF2	2	207169716	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	27641105	207169716	36029657	22	34105										
OGG1	4968	broad.mit.edu	37	chr3	9798767	9798767	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gctgttcagtgccgacctgcGccaatcccgccatgctcagg	11	16	2	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:9798767G>A	uc003bsi.2	+	7	1314	c.971G>A	c.(970-972)CGC>CAC	p.R324H	OGG1_uc003bsh.2_3'UTR|OGG1_uc003bsj.2_Missense_Mutation_p.A330T|OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Missense_Mutation_p.A95T|OGG1_uc010hcm.1_Missense_Mutation_p.A117T|OGG1_uc003bsq.1_Missense_Mutation_p.A39T|OGG1_uc003bsr.1_Missense_Mutation_p.R89H	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	324					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					GCCGACCTGCGCCAATCCCGC	0.602								BER_DNA_glycosylases					0	0	0	0.012213	0	32	110										A	9798767	G	A	9798767	3	1	112	1	0	0	0	0	1	0	0	0	10845	1087	38	2	1041	2	OGG1	3	9798767	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		9798767	188223663	23	34106										
PPARG	5468	broad.mit.edu	37	chr3	12475606	12475606	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cggagacagacatgagtcttCacccgctcctgcaggagatc	11	13	2	4			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:12475606C>T	uc003bwx.2	+	7	1571	c.1480C>T	c.(1480-1482)CAC>TAC	p.H494Y	PPARG_uc003bwr.2_Missense_Mutation_p.H466Y|PPARG_uc003bws.2_Missense_Mutation_p.H466Y|PPARG_uc003bwu.2_Missense_Mutation_p.H466Y|PPARG_uc003bwv.2_3'UTR	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	494	Ligand-binding.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	CATGAGTCTTCACCCGCTCCT	0.502			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						0	0	0	0.012213	0	29	16										T	12475606	C	T	12475606	3	4	112	1	0	0	0	0	1	0	0	0	12299	826	29	1	1506	1	PPARG	3	12475606	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	2676839	12475606	185546824	24	34107										
GLYCTK	132158	broad.mit.edu	37	chr3	52326880	52326880	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tggagcagagttgagaaggtGgccgctggggccgatagatg	19	6	0	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:52326880G>T	uc003ddo.2	+	5	1406	c.1310G>T	c.(1309-1311)TGG>TTG	p.W437L	GLYCTK_uc003ddq.2_3'UTR|GLYCTK_uc003ddm.2_Intron|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Intron|GLYCTK_uc003ddr.2_Missense_Mutation_p.W101L	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	437					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		TTGAGAAGGTGGCCGCTGGGG	0.662													1	0	1.81118e-26	0.00361	2.13279e-26	44	34										T	52326880	G	T	52326880	3	4	112	1	0	0	0	0	1	0	0	0	6482	1357	47	4	1324	4	GLYCTK	3	52326880	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	39851274	52326880	145695550	25	34108										
OR5K1	26339	broad.mit.edu	37	chr3	98188871	98188871	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgaccacaggggccttcataGctggaaacctgcattccatg	10	12	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:98188871G>T	uc003dsm.2	+	1	451	c.451G>T	c.(451-453)GCT>TCT	p.A151S		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGCCTTCATAGCTGGAAACCT	0.443													1	0	4.14481e-20	0.00623	4.79125e-20	39	76										T	98188871	G	T	98188871	3	4	112	1	0	0	0	0	1	0	0	0	11166	971	34	4	453	4	OR5K1	3	98188871	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	45861991	98188871	99833559	26	34109										
TAGLN3	29114	broad.mit.edu	37	chr3	111719695	111719695	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gatctcagagtcaaagatggCttttaagcagatggagcaaa	11	6	2	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:111719695C>T	uc003dym.2	+	3	635	c.257C>T	c.(256-258)GCT>GTT	p.A86V	TAGLN3_uc003dyl.2_Missense_Mutation_p.A86V|TAGLN3_uc003dyn.2_Missense_Mutation_p.A86V|TAGLN3_uc003dyo.2_Missense_Mutation_p.A86V	NM_001008272	NP_001008273	Q9UI15	TAGL3_HUMAN	transgelin 3	86	CH.				central nervous system development|muscle organ development						0						TCAAAGATGGCTTTTAAGCAG	0.488													0	0	0	0.00361	0	60	225										T	111719695	C	T	111719695	3	4	112	1	0	0	0	0	1	0	0	0	15537	797	28	2	263	2	TAGLN3	3	111719695	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	13530824	111719695	86302735	27	34110										
GRAMD1C	54762	broad.mit.edu	37	chr3	113627845	113627845	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ccaaaatgagaaacagaccaAaaagagtctcttaccaactt	5	10	1	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:113627845A>C	uc003eaq.3	+	9	906	c.830A>C	c.(829-831)AAA>ACA	p.K277T	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.K110T|GRAMD1C_uc003eas.2_Missense_Mutation_p.K72T	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	277						integral to membrane				ovary(2)|skin(1)	3						AAACAGACCAAAAAGAGTCTC	0.363													0	0	0	0.00361	0	77	20										C	113627845	A	C	113627845	3	2	112	1	0	0	0	0	1	0	0	0	6749	14	1	5	864	5	GRAMD1C	3	113627845	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	1908150	113627845	84394585	28	34111										
PARP15	165631	broad.mit.edu	37	chr3	122354758	122354758	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aatgggagaaagcacatgtaCgttgtgcgagtacttactgg	13	6	0	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:122354758C>A	uc003efm.2	+	12	1914	c.1848C>A	c.(1846-1848)TAC>TAA	p.Y616*	PARP15_uc003efn.2_Nonsense_Mutation_p.Y421*|PARP15_uc003efo.1_Nonsense_Mutation_p.Y363*|PARP15_uc003efp.1_Nonsense_Mutation_p.Y382*|PARP15_uc011bjt.1_Nonsense_Mutation_p.Y313*	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	594	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		AGCACATGTACGTTGTGCGAG	0.483													1	0	1.33834e-09	0.007413	1.44129e-09	19	65										A	122354758	C	A	122354758	4	1	112	1	0	0	0	0	0	1	0	0	11459	547	19	4	1963	4	PARP15	3	122354758	Nonsense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	8726913	122354758	75667672	29	34112										
CEP63	80254	broad.mit.edu	37	chr3	134278206	134278206	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgccttcagcgctagatacaAatgaagccaatttttctgac	7	10	2	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:134278206A>G	uc003eqo.1	+	15	2337	c.1888A>G	c.(1888-1890)AAT>GAT	p.N630D	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	630					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						GCTAGATACAAATGAAGCCAA	0.403													0	0	0	0.008871	0	21	60										G	134278206	A	G	134278206	3	3	112	1	0	0	0	0	1	0	0	0	3257	14	1	5	1938	5	CEP63	3	134278206	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	11923448	134278206	63744224	30	34113										
SI	6476	broad.mit.edu	37	chr3	164697153	164697153	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aaaattgatggtgatcttcaTgaccagttgatttctattgg	9	5	3	4			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:164697153T>A	uc003fei.2	-	48	5543	c.5481A>T	c.(5479-5481)TCA>TCT	p.S1827S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1827	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTGATCTTCATGACCAGTTGA	0.318										HNSCC(35;0.089)			0	0	0	0.008361	0	28	117										A	164697153	T	A	164697153	2	1	112	1	0	0	0	0	0	0	0	1	14297	1451	51	5		5	SI	3	164697153	Silent	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	30418947	164697153	33325277	31	34114										
WDR1	9948	broad.mit.edu	37	chr4	10079467	10079467	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tcgtgggagtaggccacgtcGgtcacggggcccttggcctc	16	13	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:10079467G>A	uc003gmf.2	-	13	1762	c.1479C>T	c.(1477-1479)ACC>ACT	p.T493T	WDR1_uc003gmg.2_Silent_p.T353T|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	493	WD 9.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		AGGCCACGTCGGTCACGGGGC	0.652													0	0	0	0.000602	0	5	8										A	10079467	G	A	10079467	2	1	112	1	0	0	0	0	0	0	0	1	17269	1103	39	2		2	WDR1	4	10079467	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		10079467	181074809	32	34115										
PCDH7	5099	broad.mit.edu	37	chr4	30726012	30726012	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ttaatggtgggcccggcagtCctgacctggcaaggcattac	13	11	0	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:30726012C>T	uc003gsk.1	+	1	3976	c.2968C>T	c.(2968-2970)CCT>TCT	p.P990S	PCDH7_uc011bxw.1_Missense_Mutation_p.P943S|PCDH7_uc011bxx.1_Missense_Mutation_p.P990S	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	990	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GCCCGGCAGTCCTGACCTGGC	0.507													0	0	0	0.006122	0	18	41										T	30726012	C	T	30726012	3	4	112	1	0	0	0	0	1	0	0	0	11516	855	30	1	2970	1	PCDH7	4	30726012	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	20646545	30726012	160428264	33	34116										
PRKG2	5593	broad.mit.edu	37	chr4	82058586	82058586	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	agagctccccacctaagcagGcctccagaagcatgtataca	8	14	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:82058586G>T	uc003hmh.2	-	12	1609	c.1595C>A	c.(1594-1596)GCC>GAC	p.A532D	PRKG2_uc011ccf.1_Missense_Mutation_p.A112D|PRKG2_uc011ccg.1_Missense_Mutation_p.A112D|PRKG2_uc011cch.1_Missense_Mutation_p.A503D	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	532	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ACCTAAGCAGGCCTCCAGAAG	0.338													1	0	4.59853e-10	0.005443	5.03839e-10	23	64										T	82058586	G	T	82058586	3	4	112	1	0	0	0	0	1	0	0	0	12523	1203	42	4	721	4	PRKG2	4	82058586	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	51332574	82058586	109095690	34	34117										
GRID2	2895	broad.mit.edu	37	chr4	94344056	94344056	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atttacgtagcaccggatcaCaaatacggaagcccacaaga	8	11	1	1	rs78407646	byFrequency	TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:94344056C>T	uc011cdt.1	+	10	1740	c.1482C>T	c.(1480-1482)CAC>CAT	p.H494H	GRID2_uc011cdu.1_Silent_p.H399H	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	494	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CACCGGATCACAAATACGGAA	0.398													0	0	0	0.012319	0	19	39										T	94344056	C	T	94344056	2	4	112	1	0	0	0	0	0	0	0	1	6772	477	17	2		2	GRID2	4	94344056	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	12285470	94344056	96810220	35	34118										
MAP1B	4131	broad.mit.edu	37	chr5	71492471	71492471	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tacctggaggctcagagagcGaggccaccgcttctgatgag	14	11	2	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:71492471G>A	uc003kbw.3	+	5	3530	c.3289G>A	c.(3289-3291)GAG>AAG	p.E1097K	MAP1B_uc010iyw.1_Missense_Mutation_p.E1114K|MAP1B_uc010iyx.1_Missense_Mutation_p.E971K|MAP1B_uc010iyy.1_Missense_Mutation_p.E971K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1097						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTCAGAGAGCGAGGCCACCGC	0.522													0	0	0	0.004482	0	8	14										A	71492471	G	A	71492471	3	1	112	1	0	0	0	0	1	0	0	0	9228	1059	37	1	3307	1	MAP1B	5	71492471	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		71492471	109422789	36	34119										
CAMK4	814	broad.mit.edu	37	chr5	110784840	110784840	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ttattagctgattttggactCtctaaaattgtggaacatca	7	6	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:110784840C>G	uc011cvj.1	+	8	663	c.564C>G	c.(562-564)CTC>CTG	p.L188L	CAMK4_uc003kpf.2_Silent_p.L188L|CAMK4_uc010jbv.2_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	188	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATTTTGGACTCTCTAAAATTG	0.299													0	0	0	0.004482	0	9	29										G	110784840	C	G	110784840	2	3	112	1	0	0	0	0	0	0	0	1	2605	900	32	1		1	CAMK4	5	110784840	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	39292369	110784840	70130420	37	34120										
FAM170A	340069	broad.mit.edu	37	chr5	118969677	118969677	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atccagagaatacatcgagaCagcccccagcctcaatcacc	6	16	2	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:118969677C>A	uc003ksm.2	+	3	444	c.234C>A	c.(232-234)GAC>GAA	p.D78E	FAM170A_uc003ksl.2_Missense_Mutation_p.D78E|FAM170A_uc003ksn.2_Missense_Mutation_p.D78E|FAM170A_uc003kso.2_Missense_Mutation_p.D31E	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	78						intracellular	zinc ion binding			skin(1)	1						TACATCGAGACAGCCCCCAGC	0.502													1	0	0.00198382	0.001984	0.00201582	7	35										A	118969677	C	A	118969677	3	1	112	1	0	0	0	0	1	0	0	0	5489	477	17	4	244	4	FAM170A	5	118969677	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	8184837	118969677	61945583	38	34121										
RAPGEF6	51735	broad.mit.edu	37	chr5	130834176	130834176	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tcttaaaccattccaatagtTtgatcccaacatccaaagga	4	11	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:130834176T>C	uc003kvn.1	-	12	1585	c.1379A>G	c.(1378-1380)AAA>AGA	p.K460R	RAPGEF6_uc003kvp.1_Missense_Mutation_p.K510R|RAPGEF6_uc003kvo.1_Missense_Mutation_p.K460R|RAPGEF6_uc010jdi.1_Missense_Mutation_p.K460R|RAPGEF6_uc010jdj.1_Missense_Mutation_p.K460R|RAPGEF6_uc003kvq.2_Missense_Mutation_p.K177R|RAPGEF6_uc003kvr.2_Missense_Mutation_p.K460R|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.K460R	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	460	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TTCCAATAGTTTGATCCCAAC	0.318													0	0	0	0.00361	0	64	23										C	130834176	T	C	130834176	3	2	112	1	0	0	0	0	1	0	0	0	13048	1841	64	5	3980	5	RAPGEF6	5	130834176	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	11864499	130834176	50081084	39	34122										
CSF1R	1436	broad.mit.edu	37	chr5	149449851	149449851	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gatgaatgtccatatgacgcTtacctctggggggtctgagg	14	8	2	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:149449851T>G	uc003lrl.2	-	8	1408	c.1213A>C	c.(1213-1215)AGC>CGC	p.S405R	CSF1R_uc011dcd.1_Missense_Mutation_p.S257R|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.S405R	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	405	Ig-like C2-type 5.|Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CATATGACGCTTACCTCTGGG	0.597													0	0	0	0.007835	0	32	21										G	149449851	T	G	149449851	3	3	112	1	0	0	0	0	1	0	0	0	3932	1609	56	5	1761	5	CSF1R	5	149449851	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	18615675	149449851	31465409	40	34123										
PECI	10455	broad.mit.edu	37	chr6	4133898	4133898	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gactggctctcattgctgttCtattcatgtgcagctgaact	9	10	3	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:4133898C>T	uc003mwf.2	-	2	135	c.98G>A	c.(97-99)AGA>AAA	p.R33K	PECI_uc003mwc.2_5'UTR|PECI_uc003mwd.2_Missense_Mutation_p.R3K|PECI_uc003mwe.2_5'UTR|PECI_uc010jnr.1_RNA|uc003mwg.1_5'Flank	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	33					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CATTGCTGTTCTATTCATGTG	0.413													0	0	0	0.00361	0	48	32										T	4133898	C	T	4133898	3	4	112	1	0	0	0	0	1	0	0	0	11716	913	32	1	1122	1	PECI	6	4133898	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		4133898	166981169	41	34124										
HIVEP1	3096	broad.mit.edu	37	chr6	12120592	12120592	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tctcattgtggcactacgtcCccctcctatacaaacactgc	5	16	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:12120592C>T	uc003nac.2	+	4	743	c.564C>T	c.(562-564)TCC>TCT	p.S188S	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	188					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCACTACGTCCCCCTCCTATA	0.448													0	0	0	0.003755	0	31	45										T	12120592	C	T	12120592	2	4	112	1	0	0	0	0	0	0	0	1	7186	610	22	2		2	HIVEP1	6	12120592	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	7986694	12120592	158994475	42	34125										
LRRC16A	55604	broad.mit.edu	37	chr6	25551263	25551264	+	Frame_Shift_Ins	INS	-	-	A													0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctattccacgtacctttgttINSaaaaatgtcctgttggagca							TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:25551263_25551264insA	uc011djw.1	+	27	2830_2831	c.2454_2455insA	c.(2452-2457)GTTAAAfs	p.V818fs	LRRC16A_uc010jpx.2_Frame_Shift_Ins_p.V818fs|LRRC16A_uc010jpy.2_Frame_Shift_Ins_p.V818fs|LRRC16A_uc003nfa.1_Frame_Shift_Ins_p.V172fs	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	818_819					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GTACCTTTGTTAAAAATGTCCT	0.381																		40	99	---	---								A	25551264	-	A	25551263	7	5	112	1	0	1	1	0	0	0	0	0	8971	1741	61	0	2560	0	LRRC16A	6	25551263	Frame_Shift_Ins	INS	-	TCGA-GD-A3OS-01A-12D-A21Z-08	13430671	25551263	145563804	43	34126										
CLIC5	53405	broad.mit.edu	37	chr6	45917028	45917028	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gtctcctccaggaactcctcGatcttattgacgtctgtctt	7	13	4	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:45917028G>T	uc003oxv.3	-	3	847	c.741C>A	c.(739-741)ATC>ATA	p.I247I	CLIC5_uc003oxu.3_Silent_p.I88I|CLIC5_uc003oxx.2_Silent_p.I88I	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	247					female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						GGAACTCCTCGATCTTATTGA	0.532													1	0	8.4185e-14	0.012213	9.47082e-14	29	73										T	45917028	G	T	45917028	2	4	112	1	0	0	0	0	0	0	0	1	3529	1048	37	3		3	CLIC5	6	45917028	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	20365765	45917028	125198039	44	34127										
BCLAF1	9774	broad.mit.edu	37	chr6	136582545	136582545	+	Frame_Shift_Del	DEL	C	C	-													0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgaagttaaagcgccctctgCcacgttgaaaagtaccacga							TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:136582545delC	uc003qgx.1	-	12	2868	c.2615delG	c.(2614-2616)GGCfs	p.G872fs	BCLAF1_uc011edb.1_Frame_Shift_Del_p.G151fs|BCLAF1_uc003qgw.1_Frame_Shift_Del_p.G699fs|BCLAF1_uc003qgy.1_Frame_Shift_Del_p.G821fs|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Frame_Shift_Del_p.G870fs	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	872					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GCGCCCTCTGCCACGTTGAAA	0.428																		81	282	---	---								-	136582545	C	-	136582545	7	5	112	1	0	1	0	1	0	0	0	0	1383	739	26	0	155	0	BCLAF1	6	136582545	Frame_Shift_Del	DEL	C	TCGA-GD-A3OS-01A-12D-A21Z-08	90665517	136582545	34532522	45	34128										
NMBR	4829	broad.mit.edu	37	chr6	142397093	142397093	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctcattatagttgaaagaccGatacatgtaaaggatgtggt	10	5	1	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:142397093G>A	uc003qiu.2	-	3	1006	c.865C>T	c.(865-867)CGG>TGG	p.R289W		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	289	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TTGAAAGACCGATACATGTAA	0.428													0	0	0	0.002299	0	23	27										A	142397093	G	A	142397093	3	1	112	1	0	0	0	0	1	0	0	0	10487	1057	37	1	311	1	NMBR	6	142397093	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	5814548	142397093	28717974	46	34129										
STXBP5	134957	broad.mit.edu	37	chr6	147648378	147648378	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gatccttatcggagagaaccCcgatctcctcgtaaatctcg	8	13	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:147648378C>T	uc003qlz.2	+	18	2207	c.2046C>T	c.(2044-2046)CCC>CCT	p.P682P	STXBP5_uc010khz.1_Silent_p.P682P|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.P353P|STXBP5_uc003qma.2_Silent_p.P29P	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	682	WD 10.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GGAGAGAACCCCGATCTCCTC	0.418													0	0	0	0.003271	0	27	23										T	147648378	C	T	147648378	2	4	112	1	0	0	0	0	0	0	0	1	15355	610	22	2		2	STXBP5	6	147648378	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	5251285	147648378	23466689	47	34130										
GLCCI1	113263	broad.mit.edu	37	chr7	8110599	8110599	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctccacttcctgctcattacCggagcagtagtactcgcagc	8	15	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:8110599C>A	uc003srk.2	+	6	1574	c.1015C>A	c.(1015-1017)CGG>AGG	p.R339R		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	339											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		TGCTCATTACCGGAGCAGTAG	0.493													1	0	2.70639e-06	0.002299	2.81823e-06	21	60										A	8110599	C	A	8110599	2	1	112	1	0	0	0	0	0	0	0	1	6431	643	23	4		4	GLCCI1	7	8110599	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		8110599	151028064	48	34131										
UPK3B	80761	broad.mit.edu	37	chr7	76140331	76140331	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cttcgatgggcttgccagcgCcagcgataccgtctggctcg	13	14	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:76140331C>T	uc003ufq.2	+	1	587	c.362C>T	c.(361-363)GCC>GTC	p.A121V	UPK3B_uc003ufo.2_Missense_Mutation_p.A66V|UPK3B_uc010ldk.1_Missense_Mutation_p.A66V	NM_030570	NP_085047	Q9BT76	UPK3B_HUMAN	uroplakin 3B isoform a	121	Lumenal (Potential).				negative regulation of gene expression	integral to membrane|plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(862;0.204)				CTTGCCAGCGCCAGCGATACC	0.632													0	0	0	0.000602	0	5	19										T	76140331	C	T	76140331	3	4	112	1	0	0	0	0	1	0	0	0	17008	739	26	2	364	2	UPK3B	7	76140331	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	68029732	76140331	82998332	49	34132										
SLC25A40	55972	broad.mit.edu	37	chr7	87476434	87476434	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gacttatcacagttactgcaCcaactaatacaaacaagtta	4	10	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:87476434C>A	uc003uje.2	-	8	812	c.461G>T	c.(460-462)GGT>GTT	p.G154V		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	154	Helical; Name=3; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					AGTTACTGCACCAACTAATAC	0.303													1	0	5.1993e-48	0.00361	6.18029e-48	116	108										A	87476434	C	A	87476434	3	1	112	1	0	0	0	0	1	0	0	0	14505	507	18	4	575	4	SLC25A40	7	87476434	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	11336103	87476434	71662229	50	34133										
TECPR1	25851	broad.mit.edu	37	chr7	97862830	97862830	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gggtggtcatccaccccataCggctcctccaagcccagtgg	11	16	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:97862830C>G	uc003upg.2	-	11	1780	c.1575G>C	c.(1573-1575)CCG>CCC	p.P525P	TECPR1_uc003uph.1_Silent_p.P455P	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	525						integral to membrane	protein binding			pancreas(1)	1						CCACCCCATACGGCTCCTCCA	0.667													0	0	0	0.000602	0	5	12										G	97862830	C	G	97862830	2	3	112	1	0	0	0	0	0	0	0	1	15740	523	19	4		4	TECPR1	7	97862830	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	10386396	97862830	61275833	51	34134										
BAIAP2L1	55971	broad.mit.edu	37	chr7	97922840	97922840	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cttggctgtcctctcatcgaAtgatgggtgccgagcgatca	12	11	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:97922840A>G	uc003upj.2	-	14	1792	c.1529T>C	c.(1528-1530)ATT>ACT	p.I510T		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	510	Binds F-actin.			Missing: Loss ability to induce the formation of actin clusters; induce the formation of long filopodia.	filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			CTCTCATCGAATGATGGGTGC	0.567													0	0	0	0.00361	0	153	90										G	97922840	A	G	97922840	3	3	112	1	0	0	0	0	1	0	0	0	1302	101	4	5	10	5	BAIAP2L1	7	97922840	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	60010	97922840	61215823	52	34135										
EXOC4	60412	broad.mit.edu	37	chr7	133314839	133314839	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ttgaaggtggaggaacaaaaTttgtctgcaaacctggagcc	12	7	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:133314839T>C	uc003vrk.2	+	10	1494	c.1459T>C	c.(1459-1461)TTT>CTT	p.F487L	EXOC4_uc011kpo.1_Missense_Mutation_p.F386L|EXOC4_uc003vrl.2_Missense_Mutation_p.F97L|EXOC4_uc011kpp.1_Missense_Mutation_p.F19L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	487					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGGAACAAAATTTGTCTGCAA	0.343													0	0	0	0.00361	0	104	61										C	133314839	T	C	133314839	3	2	112	1	0	0	0	0	1	0	0	0	5306	1493	52	5	1506	5	EXOC4	7	133314839	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	35391999	133314839	25823824	53	34136										
CNTNAP2	26047	broad.mit.edu	37	chr7	147869367	147869367	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ccagcagggcttcctgggctGcatccgctccttgaggatga	13	13	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:147869367G>A	uc003weu.1	+	18	3323	c.2807G>A	c.(2806-2808)TGC>TAC	p.C936Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	936	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTCCTGGGCTGCATCCGCTCC	0.532										HNSCC(39;0.1)			0	0	0	0.004482	0	9	65										A	147869367	G	A	147869367	3	1	112	1	0	0	0	0	1	0	0	0	3647	1319	46	2	2877	2	CNTNAP2	7	147869367	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	14554528	147869367	11269296	54	34137										
SORBS3	10174	broad.mit.edu	37	chr8	22412401	22412401	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cgtgatccggaatggtggctCcaacacccttaatttccagt	9	12	0	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:22412401C>T	uc003xbv.2	+	3	468	c.128C>T	c.(127-129)TCC>TTC	p.S43F	SORBS3_uc011kzk.1_RNA	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	43					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		AATGGTGGCTCCAACACCCTT	0.657													0	0	0	0.010771	0	39	57										T	22412401	C	T	22412401	3	4	112	1	0	0	0	0	1	0	0	0	14929	855	30	1	134	1	SORBS3	8	22412401	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		22412401	123951621	55	34138										
ZFHX4	79776	broad.mit.edu	37	chr8	77766952	77766952	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aaaaagaaggagggaatagcGgtgaagaccaacaccgagat	13	6	0	4			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:77766952G>A	uc003yav.2	+	10	8047	c.7660G>A	c.(7660-7662)GGT>AGT	p.G2554S	ZFHX4_uc003yau.1_Missense_Mutation_p.G2599S|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2554S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2554						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGGGAATAGCGGTGAAGACCA	0.458										HNSCC(33;0.089)			0	0	0	0.001368	0	12	29										A	77766952	G	A	77766952	3	1	112	1	0	0	0	0	1	0	0	0	17632	1116	39	2	7829	2	ZFHX4	8	77766952	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	55354551	77766952	68597070	56	34139										
SLC10A5	347051	broad.mit.edu	37	chr8	82606405	82606405	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	caattttagaaacaggaataTggaatgtacctgacaaccct	7	8	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:82606405T>G	uc011lfs.1	-	1	803	c.803A>C	c.(802-804)CAT>CCT	p.H268P		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	268	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity				0						AACAGGAATATGGAATGTACC	0.363													0	0	0	0.000602	0	4	123										G	82606405	T	G	82606405	3	3	112	1	0	0	0	0	1	0	0	0	14377	1464	51	5	515	5	SLC10A5	8	82606405	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	4839453	82606405	63757617	57	34140										
STK3	6788	broad.mit.edu	37	chr8	99468111	99468111	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tttctttgcatccatcgcatCcagaatgggctgtcttttcg	8	11	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:99468111C>G	uc003yip.2	-	11	1576	c.1435G>C	c.(1435-1437)GAT>CAT	p.D479H	STK3_uc003yio.2_Missense_Mutation_p.D507H	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	479	SARAH.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		TCCATCGCATCCAGAATGGGC	0.423													0	0	0	0.00278	0	20	25										G	99468111	C	G	99468111	3	3	112	1	0	0	0	0	1	0	0	0	15294	855	30	1	44	1	STK3	8	99468111	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	16861706	99468111	46895911	58	34141										
RSPO2	340419	broad.mit.edu	37	chr8	108972969	108972969	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tcatcaaagcaacggcctctAtgcaaataaaagcctacttt	5	11	3	0	rs113070894		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:108972969A>G	uc003yms.2	-	4	1018	c.360T>C	c.(358-360)CAT>CAC	p.H120H	RSPO2_uc003ymq.2_Silent_p.H53H|RSPO2_uc003ymr.2_Silent_p.H57H	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	120	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			AACGGCCTCTATGCAAATAAA	0.358													0	0	0	0.004289	0	30	46										G	108972969	A	G	108972969	2	3	112	1	0	0	0	0	0	0	0	1	13710	446	16	5		5	RSPO2	8	108972969	Silent	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	9504858	108972969	37391053	59	34142										
SLC30A8	169026	broad.mit.edu	37	chr8	118159254	118159254	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ccagagagagaccagaggagCtggagtcaggaggcatgtac	16	8	1	3	rs148043363	byFrequency	TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:118159254C>A	uc003yoh.2	+	2	363	c.133C>A	c.(133-135)CTG>ATG	p.L45M	SLC30A8_uc010mcz.2_Translation_Start_Site|SLC30A8_uc011lia.1_Translation_Start_Site|SLC30A8_uc003yog.2_Translation_Start_Site	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	45	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			ACCAGAGGAGCTGGAGTCAGG	0.502													1	0	4.16155e-14	0.00874	4.72392e-14	43	95										A	118159254	C	A	118159254	3	1	112	1	0	0	0	0	1	0	0	0	14561	796	28	4	139	4	SLC30A8	8	118159254	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	9186285	118159254	28204768	60	34143										
PARP10	84875	broad.mit.edu	37	chr8	145057980	145057980	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cagcagttctcggacctcctCtgggggcagggagaggccat	15	12	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:145057980C>T	uc003zal.3	-	8	1886	c.1778_splice	c.e8-1	p.E593_splice	PARP10_uc003zak.3_Splice_Site_p.E290_splice|PARP10_uc011lku.1_Splice_Site_p.E605_splice|PARP10_uc011lkv.1_Splice_Site|PARP10_uc003zam.2_Splice_Site_p.E584_splice	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10							Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGACCTCCTCTGGGGGCAGG	0.632													0	0	0	0.008291	0	9	35										T	145057980	C	T	145057980	5	4	112	1	0	0	0	0	0	0	1	0	11455	927	32	1	1316	1	PARP10	8	145057980	Splice_Site	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	26898726	145057980	1306042	61	34144										
CDKN2A	1029	broad.mit.edu	37	chr9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ggcagcgtcgtgcacgggtcGggtgagagtggcggggtcgg	23	8	0	1	rs121913388		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.00245	0	10	2										A	21971120	G	A	21971120	4	1	112	1	0	0	0	0	0	1	0	0	3161	1125	39	2	240	2	CDKN2A	9	21971120	Nonsense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		21971120	119242311	62	34145										
ZCCHC6	79670	broad.mit.edu	37	chr9	88937354	88937354	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	acagtccttctttagatgacCctctcgtttgcataagctgc	7	12	2	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:88937354C>A	uc004aoq.2	-	14	3129	c.2914G>T	c.(2914-2916)GGT>TGT	p.G972C	ZCCHC6_uc010mqe.2_5'Flank|ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Intron|ZCCHC6_uc004aou.2_Missense_Mutation_p.G972C	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	972	CCHC-type 1.				RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TTTAGATGACCCTCTCGTTTG	0.408													1	0	3.41278e-10	0.00499	3.77202e-10	15	36										A	88937354	C	A	88937354	3	1	112	1	0	0	0	0	1	0	0	0	17589	623	22	4	1629	4	ZCCHC6	9	88937354	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	66966234	88937354	52276077	63	34146										
DAPK1	1612	broad.mit.edu	37	chr9	90262309	90262309	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aacaaatgccctttggatgtGaaagacaaggtaaggccact	10	8	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:90262309G>T	uc004apc.2	+	14	1458	c.1320G>T	c.(1318-1320)GTG>GTT	p.V440V	DAPK1_uc004ape.2_Silent_p.V440V|DAPK1_uc004apd.2_Silent_p.V440V|DAPK1_uc011ltg.1_Silent_p.V440V|DAPK1_uc011lth.1_Silent_p.V177V|DAPK1_uc004apf.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	440	ANK 2.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CTTTGGATGTGAAAGACAAGG	0.522									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				1	0	6.94344e-10	0.006122	7.54202e-10	15	47										T	90262309	G	T	90262309	2	4	112	1	0	0	0	0	0	0	0	1	4235	1277	45	3		3	DAPK1	9	90262309	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	1324955	90262309	50951122	64	34147										
CKS2	1164	broad.mit.edu	37	chr9	91926143	91926143	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gagttgttgcctgggctggaCgtggttttgtctgctgcgcc	16	9	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:91926143C>T	uc004aqh.2	+	1	31	c.-64C>T	c.(-66--62)GACGT>GATGT		hsa-mir-3153|MI0014180_5'Flank	NM_001827	NP_001818	P33552	CKS2_HUMAN	CDC28 protein kinase 2						cell division|cell proliferation|phosphatidylinositol-mediated signaling|regulation of cyclin-dependent protein kinase activity|spindle organization		cyclin-dependent protein kinase regulator activity				0						CTGGGCTGGACGTGGTTTTGT	0.607													0	0	0	0.001984	0	7	22										T	91926143	C	T	91926143	1	4	112	1	0	0	0	0	0	0	0	0	3453	551	19	2		2	CKS2	9	91926143	Translation_Start_Site	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	1663834	91926143	49287288	65	34148										
ABL1	25	broad.mit.edu	37	chr9	133729585	133729585	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ttttcgttgcactgtatgatTttgtggccagtggagataac	11	6	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:133729585T>G	uc004bzw.2	+	2	217	c.214T>G	c.(214-216)TTT>GTT	p.F72V	ABL1_uc004bzv.2_Missense_Mutation_p.F91V	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	72	SH3.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	ACTGTATGATTTTGTGGCCAG	0.488			T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.009096	0	4	89										G	133729585	T	G	133729585	3	3	112	1	0	0	0	0	1	0	0	0	92	1841	64	5	360	5	ABL1	9	133729585	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	41803442	133729585	7483846	66	34149										
HSPA14	51182	broad.mit.edu	37	chr10	14891755	14891755	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tattgggctcagatgcaaatGatgtagttattactgtcccg	10	7	1	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:14891755G>A	uc001inf.2	+	6	553	c.412G>A	c.(412-414)GAT>AAT	p.D138N	HSPA14_uc010qbw.1_Missense_Mutation_p.D138N	NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	138					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						AGATGCAAATGATGTAGTTAT	0.338													0	0	0	0.007413	0	13	87										A	14891755	G	A	14891755	3	1	112	1	0	0	0	0	1	0	0	0	7407	1290	45	1	434	1	HSPA14	10	14891755	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		14891755	120642992	67	34150										
OIT3	170392	broad.mit.edu	37	chr10	74690368	74690368	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aagcacttccaggtccctgtCttcaagtttgtgggcaaaga	10	10	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:74690368C>T	uc001jte.1	+	8	1658	c.1440C>T	c.(1438-1440)GTC>GTT	p.V480V	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	480	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					AGGTCCCTGTCTTCAAGTTTG	0.438													0	0	0	0.00361	0	60	131										T	74690368	C	T	74690368	2	4	112	1	0	0	0	0	0	0	0	1	10849	900	32	1		1	OIT3	10	74690368	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	59798613	74690368	60844379	68	34151										
MGEA5	10724	broad.mit.edu	37	chr10	103560119	103560119	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atcactgccttcattttctaAttttatctggatggacacag	6	9	4	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:103560119A>T	uc001ktv.2	-	8	1518	c.1075T>A	c.(1075-1077)TTA>ATA	p.L359I	MGEA5_uc001ktu.2_5'Flank|MGEA5_uc010qqe.1_Intron|MGEA5_uc009xws.2_Intron|MGEA5_uc001ktw.2_Missense_Mutation_p.L359I|MGEA5_uc009xwt.2_Missense_Mutation_p.L122I	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	359					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TCATTTTCTAATTTTATCTGG	0.343													0	0	0	0.010504	0	19	45										T	103560119	A	T	103560119	3	4	112	1	0	0	0	0	1	0	0	0	9555	98	4	5	1711	5	MGEA5	10	103560119	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	28869751	103560119	31974628	69	34152										
DOCK1	1793	broad.mit.edu	37	chr10	128925983	128925983	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atggagaaacttctccggacCgtgaaccgaaccgtcatttc	9	12	2	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:128925983C>T	uc001ljt.2	+	27	2803	c.2739C>T	c.(2737-2739)ACC>ACT	p.T913T	DOCK1_uc010qun.1_Silent_p.T934T	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	913					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TTCTCCGGACCGTGAACCGAA	0.483													0	0	0	0.001984	0	4	68										T	128925983	C	T	128925983	2	4	112	1	0	0	0	0	0	0	0	1	4684	639	23	2		2	DOCK1	10	128925983	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	25365864	128925983	6608764	70	34153										
EXT2	2132	broad.mit.edu	37	chr11	44146519	44146519	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	aagcaccaggtcttcgattaCccacaggtgctacaggtgag	11	11	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:44146519C>G	uc001mxz.2	+	5	1258	c.924C>G	c.(922-924)TAC>TAG	p.Y308*	EXT2_uc010rfo.1_Nonsense_Mutation_p.Y336*|EXT2_uc001mxy.2_Nonsense_Mutation_p.Y321*|EXT2_uc009ykt.2_Nonsense_Mutation_p.Y308*|EXT2_uc001mya.2_Nonsense_Mutation_p.Y341*	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	308	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						TCTTCGATTACCCACAGGTGC	0.488			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				0	0	0	0.007413	0	17	38										G	44146519	C	G	44146519	4	3	112	1	0	0	0	0	0	1	0	0	5324	518	18	4	1041	4	EXT2	11	44146519	Nonsense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		44146519	90859997	71	34154										
OR4C46	119749	broad.mit.edu	37	chr11	51516060	51516060	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atttgtgtacatgagacctgCagctactttacctattgata	7	8	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:51516060C>A	uc010ric.1	+	1	779	c.779C>A	c.(778-780)GCA>GAA	p.A260E		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGAGACCTGCAGCTACTTTA	0.423													1	0	3.17567e-06	0.008361	3.27979e-06	19	49										A	51516060	C	A	51516060	3	1	112	1	0	0	0	0	1	0	0	0	11051	710	25	4	781	4	OR4C46	11	51516060	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	7369541	51516060	83490456	72	34155										
PLCB3	5331	broad.mit.edu	37	chr11	64029989	64029989	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	agtccttcgaccccttcactGaggtcatcgtggatggcatc	10	13	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:64029989G>A	uc001nzb.2	+	18	2149	c.2149G>A	c.(2149-2151)GAG>AAG	p.E717K	PLCB3_uc009ypg.1_Missense_Mutation_p.E717K|PLCB3_uc009yph.1_Missense_Mutation_p.E650K|PLCB3_uc009ypi.2_Missense_Mutation_p.E717K	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	717	C2.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCCCTTCACTGAGGTCATCGT	0.647													0	0	0	0.00499	0	17	35										A	64029989	G	A	64029989	3	1	112	1	0	0	0	0	1	0	0	0	12029	1291	45	1	2219	1	PLCB3	11	64029989	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	12513929	64029989	70976527	73	34156										
ANGPTL5	253935	broad.mit.edu	37	chr11	101762080	101762080	+	Frame_Shift_Del	DEL	T	T	-													0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	taatcttgacaggtgagttgTttttggtccacgtgccccat							TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:101762080delT	uc001pgl.2	-	9	1693	c.1097delA	c.(1096-1098)AACfs	p.N366fs		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	366	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		AGGTGAGTTGTTTTTGGTCCA	0.348																		7	1294	---	---								-	101762080	T	-	101762080	7	5	112	1	0	1	0	1	0	0	0	0	617	1725	60	0	73	0	ANGPTL5	11	101762080	Frame_Shift_Del	DEL	T	TCGA-GD-A3OS-01A-12D-A21Z-08	37732091	101762080	33244436	74	34157										
SLCO1C1	53919	broad.mit.edu	37	chr12	20859006	20859006	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cattgcaatgcctcagttctTcatggagcagtaagtctaaa	8	9	4	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:20859006T>C	uc001rej.3	+	5	750	c.395T>C	c.(394-396)TTC>TCC	p.F132S	SLCO1C1_uc010sii.1_Missense_Mutation_p.F132S|SLCO1C1_uc010sij.1_Missense_Mutation_p.F132S|SLCO1C1_uc009zip.2_Intron|SLCO1C1_uc001rei.2_Missense_Mutation_p.F132S|SLCO1C1_uc010sik.1_Missense_Mutation_p.F14S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	132	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CCTCAGTTCTTCATGGAGCAG	0.388													0	0	0	0.00361	0	53	76										C	20859006	T	C	20859006	3	2	112	1	0	0	0	0	1	0	0	0	14725	1783	62	5	405	5	SLCO1C1	12	20859006	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08		20859006	112992889	75	34158										
KIF21A	55605	broad.mit.edu	37	chr12	39730925	39730925	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ttacgttgatcctttttcaaCtgagcaatctctctgtttct	5	10	4	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:39730925C>A	uc001rly.2	-	17	2537	c.2391G>T	c.(2389-2391)CAG>CAT	p.Q797H	KIF21A_uc001rlw.2_Missense_Mutation_p.Q114H|KIF21A_uc001rlx.2_Missense_Mutation_p.Q784H|KIF21A_uc001rlz.2_Missense_Mutation_p.Q784H|KIF21A_uc010skl.1_Missense_Mutation_p.Q784H	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	797					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCTTTTTCAACTGAGCAATCT	0.333													1	0	2.55716e-62	0.00361	3.06859e-62	108	45										A	39730925	C	A	39730925	3	1	112	1	0	0	0	0	1	0	0	0	8288	564	20	4	2721	4	KIF21A	12	39730925	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	18871919	39730925	94120970	76	34159										
SFRS2IP	9169	broad.mit.edu	37	chr12	46318787	46318787	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgctgcattacattcatttgCggttgcatcatatttatagg	8	7	2	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:46318787C>T	uc001rox.2	-	12	3917	c.3630G>A	c.(3628-3630)CCG>CCA	p.P1210P	SFRS2IP_uc001row.2_Silent_p.P895P	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1210					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CATTCATTTGCGGTTGCATCA	0.378													0	0	0	0.012319	0	18	50										T	46318787	C	T	46318787	2	4	112	1	0	0	0	0	0	0	0	1	14177	755	27	2		2	SFRS2IP	12	46318787	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	6587862	46318787	87533108	77	34160										
CPSF6	11052	broad.mit.edu	37	chr12	69652373	69652373	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tctcctttgttttttagctgGacagactccaccacgtccac	6	14	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:69652373G>C	uc001sut.3	+	6	808	c.698G>C	c.(697-699)GGA>GCA	p.G233A	CPSF6_uc001suu.3_Missense_Mutation_p.G270A|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	233	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TTTTTAGCTGGACAGACTCCA	0.458													0	0	0	0.004656	0	22	32										C	69652373	G	C	69652373	3	2	112	1	0	0	0	0	1	0	0	0	3829	1174	41	1	720	1	CPSF6	12	69652373	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	23333586	69652373	64199522	78	34161										
SSH1	54434	broad.mit.edu	37	chr12	109194663	109194664	+	Frame_Shift_Del	DEL	AT	AT	-													0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gcaaataagccaggaaaaaaAttatcgatttctctggtaac							TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:109194663_109194664delAT	uc001tnm.2	-	12	1127_1128	c.1040_1041delAT	c.(1039-1041)AATfs	p.N347fs	SSH1_uc001tnl.2_Frame_Shift_Del_p.N35fs|SSH1_uc010sxg.1_Frame_Shift_Del_p.N358fs|SSH1_uc001tnn.3_Frame_Shift_Del_p.N347fs	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	347	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						CAGGAAAAAAATTATCGATTTC	0.351																		36	98	---	---								-	109194664	AT	-	109194663	7	5	112	1	0	1	0	1	0	0	0	0	15183	98	4	0	2310	0	SSH1	12	109194663	Frame_Shift_Del	DEL	AT	TCGA-GD-A3OS-01A-12D-A21Z-08	39542290	109194663	24657232	79	34162										
DDX55	57696	broad.mit.edu	37	chr12	124104079	124104079	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ccagattttgtgcccgtggaCgttaataccgacacgattcc	9	12	0	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:124104079C>T	uc001ufi.2	+	13	1458	c.1434C>T	c.(1432-1434)GAC>GAT	p.D478D	DDX55_uc001ufh.2_3'UTR|DDX55_uc001ufk.2_Silent_p.D331D|DDX55_uc001ufl.2_Silent_p.D85D	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	478							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TGCCCGTGGACGTTAATACCG	0.393													0	0	0	0.012319	0	21	61										T	124104079	C	T	124104079	2	4	112	1	0	0	0	0	0	0	0	1	4373	535	19	2		2	DDX55	12	124104079	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	14909416	124104079	9747816	80	34163										
PCDH17	27253	broad.mit.edu	37	chr13	58207677	58207677	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tggggcctaaccctatcccaGcccactgcaaagtcacggtc	9	16	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr13:58207677G>T	uc001vhq.1	+	1	1889	c.997G>T	c.(997-999)GCC>TCC	p.A333S	PCDH17_uc010aec.1_Missense_Mutation_p.A333S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	333	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCTATCCCAGCCCACTGCAA	0.627													1	0	1.64293e-13	0.00333	1.83194e-13	21	51										T	58207677	G	T	58207677	3	4	112	1	0	0	0	0	1	0	0	0	11512	971	34	4	999	4	PCDH17	13	58207677	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		58207677	56962201	81	34164										
GPC5	2262	broad.mit.edu	37	chr13	92345804	92345804	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cacttttctgcaggcactcaAtctgggcattgaagtcatca	8	11	5	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr13:92345804A>T	uc010tif.1	+	3	1055	c.689A>T	c.(688-690)AAT>ATT	p.N230I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	230						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CAGGCACTCAATCTGGGCATT	0.542													0	0	0	0.003954	0	27	6										T	92345804	A	T	92345804	3	4	112	1	0	0	0	0	1	0	0	0	6601	101	4	5	699	5	GPC5	13	92345804	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	34138127	92345804	22824074	82	34165										
AKAP6	9472	broad.mit.edu	37	chr14	33291375	33291375	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	attaccaaacatacccctgaCtgtttgggagaagaattaca	7	9	0	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr14:33291375C>T	uc001wrq.2	+	13	4526	c.4356C>T	c.(4354-4356)GAC>GAT	p.D1452D		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1452					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATACCCCTGACTGTTTGGGAG	0.363													0	0	0	0.003954	0	24	19										T	33291375	C	T	33291375	2	4	112	1	0	0	0	0	0	0	0	1	455	564	20	2		2	AKAP6	14	33291375	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		33291375	74058165	83	34166										
DACT1	51339	broad.mit.edu	37	chr14	59113073	59113073	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ggggccacaggaacatgggcGtcgtgaagaactccagcctg	15	11	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr14:59113073G>A	uc001xdw.2	+	4	1896	c.1732G>A	c.(1732-1734)GTC>ATC	p.V578I	DACT1_uc010trv.1_Missense_Mutation_p.V297I|DACT1_uc001xdx.2_Missense_Mutation_p.V541I|DACT1_uc010trw.1_Missense_Mutation_p.V297I	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	578					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GAACATGGGCGTCGTGAAGAA	0.657													0	0	0	0.00308	0	7	19										A	59113073	G	A	59113073	3	1	112	1	0	0	0	0	1	0	0	0	4222	1145	40	2	1746	2	DACT1	14	59113073	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	25821698	59113073	48236467	84	34167										
FMN1	342184	broad.mit.edu	37	chr15	33091032	33091032	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tagatatgtttttactctccCgtttccaaattgtcttgaag	6	8	2	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr15:33091032C>T	uc001zhf.3	-	15	3434	c.3434G>A	c.(3433-3435)CGG>CAG	p.R1145Q		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1368	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TTTACTCTCCCGTTTCCAAAT	0.408													0	0	0	0.001368	0	11	14										T	33091032	C	T	33091032	3	4	112	1	0	0	0	0	1	0	0	0	5949	652	23	2	168	2	FMN1	15	33091032	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		33091032	69440360	85	34168										
COX5A	9377	broad.mit.edu	37	chr15	75221462	75221462	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ttatgttccaattacctttaCgcaattcccaggcatctata	4	11	1	0	rs150174803		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr15:75221462C>T	uc002azi.3	-	2	352	c.212G>A	c.(211-213)CGT>CAT	p.R71H		NM_004255	NP_004246	P20674	COX5A_HUMAN	cytochrome c oxidase subunit Va precursor	71					respiratory electron transport chain	mitochondrial inner membrane	cytochrome-c oxidase activity|electron carrier activity|metal ion binding				0						ATTACCTTTACGCAATTCCCA	0.413													0	0	0	0.00361	0	48	72										T	75221462	C	T	75221462	3	4	112	1	0	0	0	0	1	0	0	0	3772	536	19	2	252	2	COX5A	15	75221462	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	42130430	75221462	27309930	86	34169										
CRAMP1L	57585	broad.mit.edu	37	chr16	1706030	1706030	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tccaaggccttctgcacagtGcactggcaggagggcggccg	15	13	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:1706030G>T	uc010uvh.1	+	9	1272	c.1272G>T	c.(1270-1272)GTG>GTT	p.V424V	CRAMP1L_uc002cmf.2_Intron	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	424						nucleus	DNA binding				0						TCTGCACAGTGCACTGGCAGG	0.667													1	0	2.27111e-07	0.001368	2.38467e-07	11	6										T	1706030	G	T	1706030	2	4	112	1	0	0	0	0	0	0	0	1	3846	1306	46	4		4	CRAMP1L	16	1706030	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		1706030	88648723	87	34170										
PRSS36	146547	broad.mit.edu	37	chr16	31150574	31150574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctccagtgggccagtgtgggGagccactggggggcaggaag	20	9	0	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:31150574G>A	uc002ebd.2	-	15	2512	c.2453C>T	c.(2452-2454)TCC>TTC	p.S818F	PRSS36_uc010vff.1_Missense_Mutation_p.S593F|PRSS36_uc010vfg.1_Missense_Mutation_p.S813F|PRSS36_uc010vfh.1_Missense_Mutation_p.S715F	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	818					proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CCAGTGTGGGGAGCCACTGGG	0.632													0	0	0	0.001368	0	10	61										A	31150574	G	A	31150574	3	1	112	1	0	0	0	0	1	0	0	0	12625	1174	41	1	118	1	PRSS36	16	31150574	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	29444544	31150574	59204179	88	34171										
CDH16	1014	broad.mit.edu	37	chr16	66948291	66948291	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	acagctggtaggtcctctccAgggcgtggtcaaggctggtg	16	10	2	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:66948291A>G	uc002eql.2	-	7	681	c.608T>C	c.(607-609)CTG>CCG	p.L203P	CDH16_uc010cdy.2_Missense_Mutation_p.L203P|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	203	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GGTCCTCTCCAGGGCGTGGTC	0.607													0	0	0	0.00333	0	25	7										G	66948291	A	G	66948291	3	3	112	1	0	0	0	0	1	0	0	0	3101	188	7	5	1929	5	CDH16	16	66948291	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	35797717	66948291	23406462	89	34172										
PKD1L2	114780	broad.mit.edu	37	chr16	81173269	81173269	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	accaggagccagcccaccagGatgcaccaccagggcaggcc	12	17	0	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:81173269G>A	uc002fgh.1	-	33	5466	c.5466C>T	c.(5464-5466)ATC>ATT	p.I1822I	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1822	Helical; (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGCCCACCAGGATGCACCACC	0.622													0	0	0	0.001168	0	5	2										A	81173269	G	A	81173269	2	1	112	1	0	0	0	0	0	0	0	1	11965	1164	41	1		1	PKD1L2	16	81173269	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	14224978	81173269	9181484	90	34173										
YBX2	51087	broad.mit.edu	37	chr17	7193038	7193038	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgctggcgtggcctggggcgGaaaggcctaaggcaaggaac	18	9	0	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:7193038G>A	uc002gfq.2	-	7	912	c.855C>T	c.(853-855)TTC>TTT	p.F285F		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	285	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GCCTGGGGCGGAAAGGCCTAA	0.672													0	0	0	0.00361	0	56	27										A	7193038	G	A	7193038	2	1	112	1	0	0	0	0	0	0	0	1	17467	1165	41	1		1	YBX2	17	7193038	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		7193038	74002172	91	34174										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	51	20										T	7577538	C	T	7577538	3	4	112	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	384500	7577538	73617672	92	34175										
LHX1	3975	broad.mit.edu	37	chr17	35300098	35300098	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ggcaactacgacttcttcccGcaaggccccccgtcctcgca	8	19	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:35300098G>A	uc002hnh.1	+	5	1887	c.891G>A	c.(889-891)CCG>CCA	p.P297P		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	297					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				ACTTCTTCCCGCAAGGCCCCC	0.637													0	0	0	0.001984	0	6	5										A	35300098	G	A	35300098	2	1	112	1	0	0	0	0	0	0	0	1	8770	1074	38	2		2	LHX1	17	35300098	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	27722560	35300098	45895112	93	34176										
KCTD2	23510	broad.mit.edu	37	chr17	73055695	73055695	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgtccgacggctggaaattcGaacaggtacatctcttaaca	9	10	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:73055695G>T	uc002jmp.2	+	4	698	c.631G>T	c.(631-633)GAA>TAA	p.E211*	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	211						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					CTGGAAATTCGAACAGGTACA	0.537													1	0	3.27435e-08	0.00245	3.49634e-08	13	15										T	73055695	G	T	73055695	4	4	112	1	0	0	0	0	0	1	0	0	8107	1059	37	3	645	3	KCTD2	17	73055695	Nonsense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	37755597	73055695	8139515	94	34177										
CARD14	79092	broad.mit.edu	37	chr17	78169063	78169063	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cttccgctccagcagccccgCgccccccagccagcagtccc	8	24	0	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:78169063C>T	uc002jxw.1	+	10	1625	c.1430C>T	c.(1429-1431)GCG>GTG	p.A477V	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.A477V|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Missense_Mutation_p.A240V|CARD14_uc010dhu.1_Missense_Mutation_p.A275V	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	477					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGCAGCCCCGCGCCCCCCAGC	0.657													0	0	0	0.010729	0	10	12										T	78169063	C	T	78169063	3	4	112	1	0	0	0	0	1	0	0	0	2646	768	27	2	1464	2	CARD14	17	78169063	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	5113368	78169063	3026147	95	34178										
NPTX1	4884	broad.mit.edu	37	chr17	78444649	78444649	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	caggcctcgaaggtccacttGgtggcccctccgtagatctc	11	15	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:78444649G>T	uc002jyp.1	-	5	1421	c.1263C>A	c.(1261-1263)ACC>ACA	p.T421T		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	421	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			AGGTCCACTTGGTGGCCCCTC	0.642													1	0	8.16277e-20	0.006999	9.35009e-20	37	19										T	78444649	G	T	78444649	2	4	112	1	0	0	0	0	0	0	0	1	10602	1335	47	4		4	NPTX1	17	78444649	Silent	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	275586	78444649	2750561	96	34179										
GNA15	2769	broad.mit.edu	37	chr19	3151744	3151744	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cgcatcaccgaggagggctaCgtccccacagctcaggacgt	12	15	2	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:3151744C>T	uc002lxf.2	+	4	783	c.525C>T	c.(523-525)TAC>TAT	p.Y175Y		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	175					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		AGGAGGGCTACGTCCCCACAG	0.637													0	0	0	0.00361	0	41	74										T	3151744	C	T	3151744	2	4	112	1	0	0	0	0	0	0	0	1	6503	547	19	2		2	GNA15	19	3151744	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		3151744	55977239	97	34180										
PRAM1	84106	broad.mit.edu	37	chr19	8563950	8563950	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gaggggagtctgagcggcctCgctgaactcaggctgcggca	17	11	2	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:8563950C>T	uc002mkd.2	-	2	762	c.742G>A	c.(742-744)GAG>AAG	p.E248K	PRAM1_uc002mkc.2_Missense_Mutation_p.E248K	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	296	Pro-rich.						lipid binding|protein binding				0						TGAGCGGCCTCGCTGAACTCA	0.632													0	0	0	0.001855	0	12	20										T	8563950	C	T	8563950	3	4	112	1	0	0	0	0	1	0	0	0	12423	893	31	1	1303	1	PRAM1	19	8563950	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	5412206	8563950	50565033	98	34181										
ZNF431	170959	broad.mit.edu	37	chr19	21365524	21365524	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gatatggcaaatgtgaacatGagaatttacagttaagaaaa	9	3	0	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:21365524G>C	uc002npp.2	+	5	565	c.418G>C	c.(418-420)GAG>CAG	p.E140Q	ZNF431_uc010ecq.2_Missense_Mutation_p.E49Q|ZNF431_uc010ecr.2_Missense_Mutation_p.E141Q	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						ATGTGAACATGAGAATTTACA	0.368													0	0	0	0.001855	0	12	34										C	21365524	G	C	21365524	3	2	112	1	0	0	0	0	1	0	0	0	17902	1291	45	1	436	1	ZNF431	19	21365524	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	12801574	21365524	37763459	99	34182										
ZNF607	84775	broad.mit.edu	37	chr19	38189554	38189554	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tatgaactctgcgatgtataGtgagtttatggctataacta	9	5	1	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:38189554G>C	uc002ohc.1	-	5	2074	c.1478C>G	c.(1477-1479)ACT>AGT	p.T493S	ZNF607_uc002ohb.1_Missense_Mutation_p.T492S	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	493	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GCGATGTATAGTGAGTTTATG	0.393													0	0	0	0.010818	0	26	99										C	38189554	G	C	38189554	3	2	112	1	0	0	0	0	1	0	0	0	18030	1029	36	4	616	4	ZNF607	19	38189554	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	16824030	38189554	20939429	100	34183										
ZNF780A	284323	broad.mit.edu	37	chr19	40580998	40580998	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	atgatatctaaaggccatctCacattccctacatacaaaag	4	11	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:40580998C>T	uc002omy.2	-	6	1576	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E451K|ZNF780A_uc010xvh.1_Missense_Mutation_p.E452K	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	451	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGGCCATCTCACATTCCCTA	0.403													0	0	0	0.00361	0	44	167										T	40580998	C	T	40580998	3	4	112	1	0	0	0	0	1	0	0	0	18149	835	29	1	705	1	ZNF780A	19	40580998	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	2391444	40580998	18547985	101	34184										
C19orf48	84798	broad.mit.edu	37	chr19	51301486	51301486	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctcctccccataggcctggtCacaatagggaagcgggggtg	14	12	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:51301486C>T	uc002ptf.2	-	5	1142	c.220G>A	c.(220-222)GAC>AAC	p.D74N	C19orf48_uc002pte.2_RNA|C19orf48_uc002ptg.2_Missense_Mutation_p.D74N	NM_199249	NP_954857	Q6RUI8	CS048_HUMAN	multidrug resistance-related protein	74										ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00531)|GBM - Glioblastoma multiforme(134;0.0145)		TAGGCCTGGTCACAATAGGGA	0.632													0	0	0	0.002299	0	23	129										T	51301486	C	T	51301486	3	4	112	1	0	0	0	0	1	0	0	0	1931	826	29	1	137	1	C19orf48	19	51301486	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	10720488	51301486	7827497	102	34185										
ZNF528	84436	broad.mit.edu	37	chr19	52909178	52909178	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	agggacccttgaaattcatgGatgtggccatagagttctct	11	8	2	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:52909178G>A	uc002pzh.2	+	5	460	c.34G>A	c.(34-36)GAT>AAT	p.D12N	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	12	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GAAATTCATGGATGTGGCCAT	0.458													0	0	0	0.009718	0	39	234										A	52909178	G	A	52909178	3	1	112	1	0	0	0	0	1	0	0	0	17966	1174	41	1	40	1	ZNF528	19	52909178	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	1607692	52909178	6219805	103	34186										
ZNF534	147658	broad.mit.edu	37	chr19	52942185	52942185	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	taggaaaattcatactggagAgaagctttacaaatgtaatg	9	4	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:52942185A>G	uc002pzk.2	+	4	1572	c.1511A>G	c.(1510-1512)GAG>GGG	p.E504G	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.E491G	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATACTGGAGAGAAGCTTTAC	0.398													0	0	0	0.000602	0	5	28										G	52942185	A	G	52942185	3	3	112	1	0	0	0	0	1	0	0	0	17970	304	11	5	1525	5	ZNF534	19	52942185	Missense_Mutation	SNP	A	TCGA-GD-A3OS-01A-12D-A21Z-08	33007	52942185	6186798	104	34187										
NLRP9	338321	broad.mit.edu	37	chr19	56243996	56243996	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	tgtatatgtccaaattccctCtgcagccaaagcacacaggc	7	13	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:56243996C>G	uc002qly.2	-	2	1229	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	401	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CAAATTCCCTCTGCAGCCAAA	0.458													0	0	0	0.003954	0	20	143										G	56243996	C	G	56243996	3	3	112	1	0	0	0	0	1	0	0	0	10484	922	32	1	1806	1	NLRP9	19	56243996	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08	3301811	56243996	2884987	105	34188										
ZNF71	58491	broad.mit.edu	37	chr19	57133733	57133733	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cgttcgagtgcagcgagtgcGgcaaggccttcagcaagaac	14	11	1	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:57133733G>A	uc002qnm.3	+	3	1316	c.1078G>A	c.(1078-1080)GGC>AGC	p.G360S		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	360	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CAGCGAGTGCGGCAAGGCCTT	0.627													0	0	0	0.012319	0	21	98										A	57133733	G	A	57133733	3	1	112	1	0	0	0	0	1	0	0	0	18111	1116	39	2	1080	2	ZNF71	19	57133733	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	889737	57133733	1995250	106	34189										
PCSK2	5126	broad.mit.edu	37	chr20	17339006	17339006	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gcagcaggaaggatttgaccGaaaaaagcgaggttacagag	14	6	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr20:17339006G>A	uc002wpm.2	+	3	637	c.317G>A	c.(316-318)CGA>CAA	p.R106Q	PCSK2_uc002wpl.2_Missense_Mutation_p.R87Q|PCSK2_uc010zrm.1_Missense_Mutation_p.R71Q	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	106					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGATTTGACCGAAAAAAGCGA	0.388													0	0	0	0.005443	0	22	52										A	17339006	G	A	17339006	3	1	112	1	0	0	0	0	1	0	0	0	11601	1058	37	1	327	1	PCSK2	20	17339006	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08		17339006	45686514	107	34190										
ADAMTS5	11096	broad.mit.edu	37	chr21	28302365	28302365	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	attactgtacagcctacattCagtgccatcggtcacctgaa	7	12	2	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr21:28302365C>T	uc002ymg.2	-	7	2794	c.2065G>A	c.(2065-2067)GAA>AAA	p.E689K		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	689	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AGCCTACATTCAGTGCCATCG	0.478													0	0	0	0.00874	0	38	102										T	28302365	C	T	28302365	3	4	112	1	0	0	0	0	1	0	0	0	269	835	29	1	735	1	ADAMTS5	21	28302365	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		28302365	19827530	108	34191										
COMT	1312	broad.mit.edu	37	chr22	19951164	19951164	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	gggggcctactgtggctactCagctgtgcgcatggcccgcc	15	14	1	0			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:19951164C>T	uc002zqu.2	+	4	614	c.365C>T	c.(364-366)TCA>TTA	p.S122L	COMT_uc002zqt.2_Missense_Mutation_p.S122L|COMT_uc002zqv.2_Missense_Mutation_p.S122L|COMT_uc002zqw.2_Missense_Mutation_p.S122L|COMT_uc011ahd.1_Missense_Mutation_p.S122L|COMT_uc002zqx.2_Missense_Mutation_p.S122L	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	122		S-adenosyl-L-methionine.			neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	TGTGGCTACTCAGCTGTGCGC	0.647													0	0	0	0.003755	0	33	38										T	19951164	C	T	19951164	3	4	112	1	0	0	0	0	1	0	0	0	3725	838	29	1	371	1	COMT	22	19951164	Missense_Mutation	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		19951164	31353402	109	34192										
MTMR3	8897	broad.mit.edu	37	chr22	30415660	30415660	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cagcctagggaagcccaccaGagtgccggggggtgccgagc	17	13	0	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:30415660G>A	uc003agv.3	+	17	2340	c.2012G>A	c.(2011-2013)AGA>AAA	p.R671K	MTMR3_uc003agu.3_Missense_Mutation_p.R671K|MTMR3_uc003agw.3_Missense_Mutation_p.R671K	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	671					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			AAGCCCACCAGAGTGCCGGGG	0.622													0	0	0	0.00361	0	53	38										A	30415660	G	A	30415660	3	1	112	1	0	0	0	0	1	0	0	0	9945	942	33	1	2070	1	MTMR3	22	30415660	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	10464496	30415660	20888906	110	34193										
ELFN2	114794	broad.mit.edu	37	chr22	37769638	37769638	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cggccggatggtcgggcacgTccaggctaaagaccttggcg	16	12	0	1			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:37769638T>A	uc003asq.3	-	3	2723	c.1937A>T	c.(1936-1938)GAC>GTC	p.D646V		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	646	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GTCGGGCACGTCCAGGCTAAA	0.672													0	0	0	0.001168	0	5	10										A	37769638	T	A	37769638	3	1	112	1	0	0	0	0	1	0	0	0	5058	1667	58	5	529	5	ELFN2	22	37769638	Missense_Mutation	SNP	T	TCGA-GD-A3OS-01A-12D-A21Z-08	7353978	37769638	13534928	111	34194										
CYB5R3	1727	broad.mit.edu	37	chr22	43032743	43032743	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	cccggtcgatgagccgcagcGggtacttgatgtccgggctc	15	13	0	2			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:43032743G>A	uc003bcz.2	-	2	215	c.131C>T	c.(130-132)CCG>CTG	p.P44L	CYB5R3_uc010gzc.1_5'UTR|CYB5R3_uc003bcw.2_Missense_Mutation_p.P34L|CYB5R3_uc011aps.1_Missense_Mutation_p.P77L|CYB5R3_uc003bcy.2_Missense_Mutation_p.P21L|CYB5R3_uc003bcx.2_Missense_Mutation_p.P21L	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	44	FAD-binding FR-type.				blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	GAGCCGCAGCGGGTACTTGAT	0.632													0	0	0	0.004482	0	7	7										A	43032743	G	A	43032743	3	1	112	1	0	0	0	0	1	0	0	0	4128	1116	39	2	806	2	CYB5R3	22	43032743	Missense_Mutation	SNP	G	TCGA-GD-A3OS-01A-12D-A21Z-08	5263105	43032743	8271823	112	34195										
ZCCHC18	644353	broad.mit.edu	37	chrX	103359015	103359015	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.176991150442478	20	0.000375548223197749	2.30684104627767	3.77967032967033	1.97672413793103	0.0328648840650265	0.0909028708181584	11	ctgatccaagtcaatgaggtCctgccagattggagtatgtc	11	9	1	3			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chrX:103359015C>T	uc011msh.1	+	3	1529	c.213C>T	c.(211-213)GTC>GTT	p.V71V	MCART6_uc004elu.2_Intron|ZCCHC18_uc011msg.1_Intron	NM_001143978	NP_001137450	P0CG32	ZCC18_HUMAN	zinc finger, CCHC domain containing 18	71							nucleic acid binding|zinc ion binding				0						TCAATGAGGTCCTGCCAGATT	0.507													0	0	0	0.003954	0	24	7										T	103359015	C	T	103359015	2	4	112	1	0	0	0	0	0	0	0	1	17583	842	30	1		1	ZCCHC18	23	103359015	Silent	SNP	C	TCGA-GD-A3OS-01A-12D-A21Z-08		103359015	51911545	113	34196										
PTCHD2	57540	broad.mit.edu	37	chr1	11596632	11596632	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	actcggacccggacttccttCctcaaggccctgggtgccgt	11	16	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:11596632C>T	uc001ash.3	+	21	4206	c.4068C>T	c.(4066-4068)TTC>TTT	p.F1356F		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1356	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GGACTTCCTTCCTCAAGGCCC	0.672													0	0	0	0.00499	0	15	14										T	11596632	C	T	11596632	2	4	113	1	0	0	0	0	0	0	0	1	12733	854	30	1		1	PTCHD2	1	11596632	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		11596632	237653989	1	34197										
AGTRAP	57085	broad.mit.edu	37	chr1	11810185	11810185	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctaccagacgattgactcagCagaggcgcccgcagatccct	10	15	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:11810185C>T	uc001asv.2	+	5	540	c.416C>T	c.(415-417)GCA>GTA	p.A139V	AGTRAP_uc001ast.2_3'UTR|AGTRAP_uc001asu.2_3'UTR|AGTRAP_uc001asw.2_Missense_Mutation_p.A132V|AGTRAP_uc001asx.2_3'UTR	NM_020350	NP_065083	Q6RW13	ATRAP_HUMAN	angiotensin II receptor-associated protein	139	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding		AGTRAP/BRAF(2)	stomach(2)	2	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.46e-06)|COAD - Colon adenocarcinoma(227;0.000256)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		ATTGACTCAGCAGAGGCGCCC	0.607													0	0	0	0.004007	0	14	35										T	11810185	C	T	11810185	3	4	113	1	0	0	0	0	1	0	0	0	403	710	25	2	535	2	AGTRAP	1	11810185	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	213553	11810185	237440436	2	34198										
EPHA8	2046	broad.mit.edu	37	chr1	22902808	22902808	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagaacaactggctgcgcacGagctgggtcccccgagacgg	14	14	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:22902808G>A	uc001bfx.1	+	3	383	c.258G>A	c.(256-258)ACG>ACA	p.T86T	EPHA8_uc001bfw.2_Silent_p.T86T	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	86	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGCTGCGCACGAGCTGGGTCC	0.617													0	0	0	0.01441	0	50	83										A	22902808	G	A	22902808	2	1	113	1	0	0	0	0	0	0	0	1	5173	1045	37	1		1	EPHA8	1	22902808	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	11092623	22902808	226347813	3	34199										
EPHA8	2046	broad.mit.edu	37	chr1	22902965	22902965	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	acctgggggccagcacacaaGaaagccagttcctcaaaatc	9	13	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:22902965G>C	uc001bfx.1	+	3	540	c.415G>C	c.(415-417)GAA>CAA	p.E139Q	EPHA8_uc001bfw.2_Missense_Mutation_p.E139Q	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	139	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CAGCACACAAGAAAGCCAGTT	0.612													0	0	0	0.011902	0	42	60										C	22902965	G	C	22902965	3	2	113	1	0	0	0	0	1	0	0	0	5173	943	33	1	425	1	EPHA8	1	22902965	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	157	22902965	226347656	4	34200										
ARID1A	8289	broad.mit.edu	37	chr1	27100988	27100988	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aagctgcccagccttcccctCagcaagatgtatacaaccag	7	15	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:27100988C>T	uc001bmv.1	+	18	4643	c.4270C>T	c.(4270-4272)CAG>TAG	p.Q1424*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1423*|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q1041*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q270*|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1424					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCCTTCCCCTCAGCAAGATGT	0.622			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.006999	0	40	68										T	27100988	C	T	27100988	4	4	113	1	0	0	0	0	0	1	0	0	913	827	29	1	4340	1	ARID1A	1	27100988	Nonsense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	4198023	27100988	222149633	5	34201										
ARID1A	8289	broad.mit.edu	37	chr1	27101586	27101586	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aggtcccccagtacctgcctCgcacatagcacctgcccctg	8	19	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:27101586C>T	uc001bmv.1	+	18	5241	c.4868C>T	c.(4867-4869)TCG>TTG	p.S1623L	ARID1A_uc001bmt.1_Missense_Mutation_p.S1622L|ARID1A_uc001bmu.1_Missense_Mutation_p.S1406L|ARID1A_uc001bmw.1_Missense_Mutation_p.S1240L|ARID1A_uc001bmx.1_Missense_Mutation_p.S469L|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1623					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTACCTGCCTCGCACATAGCA	0.602			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	52	78										T	27101586	C	T	27101586	3	4	113	1	0	0	0	0	1	0	0	0	913	893	31	1	4938	1	ARID1A	1	27101586	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	598	27101586	222149035	6	34202										
FAM76A	199870	broad.mit.edu	37	chr1	28086093	28086093	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcgcagatgagagccaaaatGaaccagatggagaaaaccca	10	9	0	5			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:28086093G>A	uc001boq.2	+	8	894	c.792G>A	c.(790-792)ATG>ATA	p.M264I	FAM76A_uc009vtb.2_Missense_Mutation_p.M264I|FAM76A_uc001bor.2_Missense_Mutation_p.M298I|FAM76A_uc001bos.2_Missense_Mutation_p.M269I|FAM76A_uc001bot.2_Missense_Mutation_p.M235I|FAM76A_uc010ofm.1_Missense_Mutation_p.M184I	NM_152660	NP_689873	Q8TAV0	FA76A_HUMAN	hypothetical protein LOC199870 isoform 3	264	Potential.										0		Colorectal(325;0.000147)|all_lung(284;0.00181)|Lung NSC(340;0.00278)|Renal(390;0.00357)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00253)|KIRC - Kidney renal clear cell carcinoma(1967;0.00292)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCCAAAATGAACCAGATGG	0.413													0	0	0	0.00333	0	22	45										A	28086093	G	A	28086093	3	1	113	1	0	0	0	0	1	0	0	0	5624	1290	45	1	928	1	FAM76A	1	28086093	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	984507	28086093	221164528	7	34203										
LRRC41	10489	broad.mit.edu	37	chr1	46745288	46745288	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagaaggagaaggtaatctcTgtcaagaaaaattatagtaa	9	4	2	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:46745288T>C	uc001cpn.2	-	8	2065	c.2021_splice	c.e8-1	p.E674_splice	LRRC41_uc010omb.1_Intron	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein											ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGGTAATCTCTGTCAAGAAAA	0.502													0	0	0	0.01441	0	59	115										C	46745288	T	C	46745288	5	2	113	1	0	0	0	0	0	0	1	0	8999	1594	55	5	431	5	LRRC41	1	46745288	Splice_Site	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	18659195	46745288	202505333	8	34204										
MCOLN3	55283	broad.mit.edu	37	chr1	85498432	85498432	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ttgatgacgaactgtctgcaGattaatggctttcagtttaa	9	6	2	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:85498432G>C	uc001dkp.2	-	6	772	c.679C>G	c.(679-681)CTG>GTG	p.L227V	MCOLN3_uc001dkq.2_Missense_Mutation_p.L171V|MCOLN3_uc001dkr.2_Missense_Mutation_p.L227V|MCOLN3_uc001dks.3_Missense_Mutation_p.L72V	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	227						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		ACTGTCTGCAGATTAATGGCT	0.408													0	0	0	0.01441	0	104	75										C	85498432	G	C	85498432	3	2	113	1	0	0	0	0	1	0	0	0	9397	933	33	1	1014	1	MCOLN3	1	85498432	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	38753144	85498432	163752189	9	34205										
DBT	1629	broad.mit.edu	37	chr1	100701034	100701034	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	taatcccttctccaatgtctGagagcttgaactgaacaacc	6	12	2	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:100701034G>C	uc001dta.2	-	3	242	c.209C>G	c.(208-210)TCA>TGA	p.S70*	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	70	Lipoyl-binding.				branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TCCAATGTCTGAGAGCTTGAA	0.289													0	0	0	0.01441	0	41	87										C	100701034	G	C	100701034	4	2	113	1	0	0	0	0	0	1	0	0	4258	1294	45	1	1275	1	DBT	1	100701034	Nonsense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	15202602	100701034	148549587	10	34206										
OLFM3	118427	broad.mit.edu	37	chr1	102462345	102462345	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aaacaaagacagcagcaggaGgttgagaaggttggacgtcg	15	6	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:102462345G>C	uc001dug.2	-	1	446	c.28C>G	c.(28-30)CTC>GTC	p.L10V	OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_5'UTR	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGCAGCAGGAGGTTGAGAAGG	0.433													0	0	0	0.005524	0	34	67										C	102462345	G	C	102462345	3	2	113	1	0	0	0	0	1	0	0	0	10854	1000	35	4	1372	4	OLFM3	1	102462345	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	1761311	102462345	146788276	11	34207										
ATP1A1	476	broad.mit.edu	37	chr1	116932977	116932977	+	Frame_Shift_Del	DEL	C	C	-													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcagaaccggatgacagtggCccacatgtggtttgacaatc							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:116932977delC	uc001ege.2	+	9	1505	c.1166delC	c.(1165-1167)GCCfs	p.A389fs	ATP1A1_uc010owv.1_Frame_Shift_Del_p.A358fs|ATP1A1_uc010oww.1_Frame_Shift_Del_p.A389fs|ATP1A1_uc010owx.1_Frame_Shift_Del_p.A358fs	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	389	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	ATGACAGTGGCCCACATGTGG	0.413																		23	46	---	---								-	116932977	C	-	116932977	7	5	113	1	0	1	0	1	0	0	0	0	1128	739	26	0	1216	0	ATP1A1	1	116932977	Frame_Shift_Del	DEL	C	TCGA-GU-A42R-01A-11D-A23M-08	14470632	116932977	132317644	12	34208										
TRIM46	80128	broad.mit.edu	37	chr1	155154488	155154488	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agtgtggatgtggtcctgggCgacgtggctgtgacccaggg	19	8	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:155154488C>T	uc001fhs.1	+	9	1832	c.1749C>T	c.(1747-1749)GGC>GGT	p.G583G	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Silent_p.G457G|TRIM46_uc001fhu.1_Silent_p.G560G|TRIM46_uc009wpg.1_Silent_p.G570G|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	583	B30.2/SPRY.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTCCTGGGCGACGTGGCTG	0.562													0	0	0	0.001855	0	14	25										T	155154488	C	T	155154488	2	4	113	1	0	0	0	0	0	0	0	1	16518	755	27	2		2	TRIM46	1	155154488	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	38221511	155154488	94096133	13	34209										
SCAMP3	10067	broad.mit.edu	37	chr1	155230165	155230165	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gctgcagctctcgctcccttCggtccaactcctctgccttc	7	19	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:155230165C>T	uc001fjs.2	-	4	597	c.344G>A	c.(343-345)CGA>CAA	p.R115Q	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_5'UTR|SCAMP3_uc001fju.2_Missense_Mutation_p.R115Q|SCAMP3_uc001fjv.2_Missense_Mutation_p.R115Q|SCAMP3_uc001fjt.2_Missense_Mutation_p.R89Q	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	115	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCGCTCCCTTCGGTCCAACTC	0.582													0	0	0	0.01441	0	59	94										T	155230165	C	T	155230165	3	4	113	1	0	0	0	0	1	0	0	0	13872	884	31	1	723	1	SCAMP3	1	155230165	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	75677	155230165	94020456	14	34210										
ARHGEF2	9181	broad.mit.edu	37	chr1	155922418	155922418	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttccctgggagctccctcaCcctcacggatggcatcctgc	9	18	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:155922418C>A	uc001fmt.2	-	15	2102	c.1984_splice	c.e15+1	p.V662_splice	ARHGEF2_uc001fmq.2_5'Flank|ARHGEF2_uc001fmr.2_Splice_Site_p.V634_splice|ARHGEF2_uc001fms.2_Splice_Site_p.V661_splice|ARHGEF2_uc001fmu.2_Splice_Site_p.V706_splice	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2						actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGCTCCCTCACCCTCACGGAT	0.607													1	0	2.46105e-21	0.010818	2.69399e-21	30	49										A	155922418	C	A	155922418	5	1	113	1	0	0	0	0	0	0	1	0	903	521	18	4	1007	4	ARHGEF2	1	155922418	Splice_Site	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	692253	155922418	93328203	15	34211										
ASTN1	460	broad.mit.edu	37	chr1	176833476	176833476	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gatactcagggtctgctcctCacacgtcttcctgaggtccc	9	15	4	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:176833476C>T	uc001glc.2	-	23	4041	c.3829G>A	c.(3829-3831)GAG>AAG	p.E1277K	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1285					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GTCTGCTCCTCACACGTCTTC	0.577													0	0	0	0.01441	0	74	102										T	176833476	C	T	176833476	3	4	113	1	0	0	0	0	1	0	0	0	1064	835	29	1	59	1	ASTN1	1	176833476	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	20911058	176833476	72417145	16	34212										
CFHR5	81494	broad.mit.edu	37	chr1	196965186	196965186	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgtggatacatacctgaactCgagtacggttatgttcagcc	10	9	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:196965186C>A	uc001gts.3	+	6	953	c.825C>A	c.(823-825)CTC>CTA	p.L275L		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	275	Sushi 5.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TACCTGAACTCGAGTACGGTT	0.348													1	0	7.82978e-24	0.01441	8.642e-24	59	108										A	196965186	C	A	196965186	2	1	113	1	0	0	0	0	0	0	0	1	3288	871	31	3		3	CFHR5	1	196965186	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	20131710	196965186	52285435	17	34213										
CYB5R1	51706	broad.mit.edu	37	chr1	202936373	202936373	+	Translation_Start_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	caccacctgacaagccgacaGatcccacaatgcgccgcggg	10	17	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:202936373G>C	uc001gyt.2	-	1	32	c.-39C>G	c.(-41--37)ATCTG>ATGTG		CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1						sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			CAAGCCGACAGATCCCACAAT	0.348													0	0	0	0.00245	0	10	20										C	202936373	G	C	202936373	1	2	113	1	0	0	0	0	0	0	0	0	4126	957	33	1		1	CYB5R1	1	202936373	Translation_Start_Site	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	5971187	202936373	46314248	18	34214										
LYST	1130	broad.mit.edu	37	chr1	235973532	235973532	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tttggggtggtcttgtttagGaaacgatgttaaaaaatgat	12	2	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:235973532G>T	uc001hxj.2	-	5	761	c.586C>A	c.(586-588)CCT>ACT	p.P196T	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.P196T	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	196					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTTGTTTAGGAAACGATGTT	0.428									Chediak-Higashi_syndrome				1	0	9.11151e-29	0.01441	1.01408e-28	87	162										T	235973532	G	T	235973532	3	4	113	1	0	0	0	0	1	0	0	0	9128	1174	41	3	11015	3	LYST	1	235973532	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	33037159	235973532	13277089	19	34215										
APOB	338	broad.mit.edu	37	chr2	21233836	21233836	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gctggagtaagcagggcactGactttgtgttcaagagctgc	14	8	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:21233836G>A	uc002red.2	-	26	6032	c.5904C>T	c.(5902-5904)GTC>GTT	p.V1968V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1968					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCAGGGCACTGACTTTGTGTT	0.453													0	0	0	0.01441	0	56	105										A	21233836	G	A	21233836	2	1	113	1	0	0	0	0	0	0	0	1	785	1277	45	1		1	APOB	2	21233836	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		21233836	221965537	20	34216										
OTOF	9381	broad.mit.edu	37	chr2	26717812	26717812	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccccacagggccactgacctCgttgtaataggggcagttag	12	12	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:26717812C>T	uc002rhk.2	-	9	1022	c.895G>A	c.(895-897)GAG>AAG	p.E299K		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	299	Cytoplasmic (Potential).|C2 1.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCACTGACCTCGTTGTAATAG	0.572													0	0	0	0.009535	0	30	82										T	26717812	C	T	26717812	3	4	113	1	0	0	0	0	1	0	0	0	11303	893	31	1	5579	1	OTOF	2	26717812	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	5483976	26717812	216481561	21	34217										
AGBL5	60509	broad.mit.edu	37	chr2	27276416	27276416	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cacccggccacgctgggaacGcattcgagaccggcccacct	11	18	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:27276416G>A	uc002rie.2	+	3	579	c.362G>A	c.(361-363)CGC>CAC	p.R121H	AGBL5_uc002ric.2_Missense_Mutation_p.R121H|AGBL5_uc002rid.2_Missense_Mutation_p.R121H|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	121					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCTGGGAACGCATTCGAGAC	0.498													0	0	0	0.006999	0	35	109										A	27276416	G	A	27276416	3	1	113	1	0	0	0	0	1	0	0	0	378	1087	38	2	368	2	AGBL5	2	27276416	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	558604	27276416	215922957	22	34218										
CDC42EP3	10602	broad.mit.edu	37	chr2	37873446	37873446	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	accggggagggcgtttctgtGaacacagagtccgaggtgct	16	9	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:37873446G>A	uc002rqi.1	-	2	1278	c.285C>T	c.(283-285)TTC>TTT	p.F95F		NM_006449	NP_006440	Q9UKI2	BORG2_HUMAN	Cdc42 effector protein 3	95					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding				0		all_hematologic(82;0.172)				GCGTTTCTGTGAACACAGAGT	0.532													0	0	0	0.01441	0	59	128										A	37873446	G	A	37873446	2	1	113	1	0	0	0	0	0	0	0	1	3077	1281	45	1		1	CDC42EP3	2	37873446	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	10597030	37873446	205325927	23	34219										
OXER1	165140	broad.mit.edu	37	chr2	42990228	42990228	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cccagcaaggcccggctctgGtggaggaagttggggctaga	17	10	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:42990228G>A	uc002rss.2	-	1	1174	c.1092C>T	c.(1090-1092)CAC>CAT	p.H364H		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	364	Cytoplasmic (Potential).				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						CCCGGCTCTGGTGGAGGAAGT	0.657													0	0	0	0.003271	0	31	39										A	42990228	G	A	42990228	2	1	113	1	0	0	0	0	0	0	0	1	11331	1252	44	2		2	OXER1	2	42990228	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	5116782	42990228	200209145	24	34220										
STON1-GTF2A1L	286749	broad.mit.edu	37	chr2	48808503	48808503	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gtcagctgagaaccaagactCacttagaagtttgtctatgc	9	9	3	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:48808503C>A	uc010yol.1	+	1	778	c.731C>A	c.(730-732)TCA>TAA	p.S244*	STON1_uc002rwo.3_Nonsense_Mutation_p.S244*|STON1_uc010fbm.2_Nonsense_Mutation_p.S244*|STON1-GTF2A1L_uc002rwp.1_Nonsense_Mutation_p.S244*|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Nonsense_Mutation_p.S244*	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	244					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AACCAAGACTCACTTAGAAGT	0.433													1	0	3.07002e-29	0.01441	3.43119e-29	51	80										A	48808503	C	A	48808503	4	1	113	1	0	0	0	0	0	1	0	0	15316	838	29	3	733	3	STON1-GTF2A1L	2	48808503	Nonsense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	5818275	48808503	194390870	25	34221										
UGP2	7360	broad.mit.edu	37	chr2	64114602	64114602	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gggctgccatcaaaagttttGagaattctctaggtattaat	9	6	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:64114602G>T	uc002scm.2	+	8	1444	c.1138G>T	c.(1138-1140)GAG>TAG	p.E380*	UGP2_uc002scl.2_Nonsense_Mutation_p.E369*|UGP2_uc010ypx.1_Nonsense_Mutation_p.E389*	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	380					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						CAAAAGTTTTGAGAATTCTCT	0.423													1	0	6.84511e-11	0.003271	7.1685e-11	36	79										T	64114602	G	T	64114602	4	4	113	1	0	0	0	0	0	1	0	0	16940	1291	45	3	1168	3	UGP2	2	64114602	Nonsense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	15306099	64114602	179084771	26	34222										
SPRED2	200734	broad.mit.edu	37	chr2	65571896	65571896	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	catggatgagaaagccgcttCgtccattgccttcggggtgc	13	11	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:65571896C>T	uc002sdr.3	-	2	696	c.161G>A	c.(160-162)CGA>CAA	p.R54Q	SPRED2_uc010fcw.2_Missense_Mutation_p.R51Q|SPRED2_uc010fcx.1_RNA	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	54	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						AAAGCCGCTTCGTCCATTGCC	0.512													0	0	0	0.003163	0	14	22										T	65571896	C	T	65571896	3	4	113	1	0	0	0	0	1	0	0	0	15092	884	31	1	1115	1	SPRED2	2	65571896	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	1457294	65571896	177627477	27	34223										
TANC1	85461	broad.mit.edu	37	chr2	160006935	160006935	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccacactaacaagcagcaccGcatctcctagcaccgatagc	6	17	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:160006935G>A	uc002uag.2	+	7	824	c.550G>A	c.(550-552)GCA>ACA	p.A184T	TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Missense_Mutation_p.A183T|TANC1_uc010fom.1_Intron|TANC1_uc002uah.1_3'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	184	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AAGCAGCACCGCATCTCCTAG	0.527													0	0	0	0.007291	0	26	51										A	160006935	G	A	160006935	3	1	113	1	0	0	0	0	1	0	0	0	15541	1087	38	2	568	2	TANC1	2	160006935	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	94435039	160006935	83192438	28	34224										
TLK1	9874	broad.mit.edu	37	chr2	172016855	172016855	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agcagggacctggccgccgcCgccgagcccggggttggaga	18	14	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:172016855C>T	uc002ugn.2	-	1	556	c.84G>A	c.(82-84)GCG>GCA	p.A28A	TLK1_uc002ugo.2_Silent_p.A28A|TLK1_uc002ugp.2_Intron|TLK1_uc002ugq.2_RNA	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	28					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TGGCCGCCGCCGCCGAGCCCG	0.507													0	0	0	0.009096	0	4	50										T	172016855	C	T	172016855	2	4	113	1	0	0	0	0	0	0	0	1	15940	639	23	2		2	TLK1	2	172016855	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	12009920	172016855	71182518	29	34225										
COL3A1	1281	broad.mit.edu	37	chr2	189876410	189876410	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tatcgaacacgcaaggctgtGagactacctattgtagatat	9	8	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:189876410G>C	uc002uqj.1	+	51	4428	c.4311G>C	c.(4309-4311)GTG>GTC	p.V1437V		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1437	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GCAAGGCTGTGAGACTACCTA	0.393													0	0	0	0.005524	0	36	83										C	189876410	G	C	189876410	2	2	113	1	0	0	0	0	0	0	0	1	3688	1277	45	1		1	COL3A1	2	189876410	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	17859555	189876410	53322963	30	34226										
ZDBF2	57683	broad.mit.edu	37	chr2	207171761	207171761	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttttgattctgatattcctCttcattcaggaaatgatcac	5	9	5	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:207171761C>G	uc002vbp.2	+	5	2759	c.2509C>G	c.(2509-2511)CTT>GTT	p.L837V		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	837							nucleic acid binding|zinc ion binding			ovary(3)	3						TGATATTCCTCTTCATTCAGG	0.358													0	0	0	0.008361	0	29	46										G	207171761	C	G	207171761	3	3	113	1	0	0	0	0	1	0	0	0	17596	913	32	1	2519	1	ZDBF2	2	207171761	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	17295351	207171761	36027612	31	34227										
DOCK10	55619	broad.mit.edu	37	chr2	225796298	225796298	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	actggggaagaacaagagatCttgaagaggatcattccggt	13	6	2	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:225796298C>G	uc010fwz.1	-	2	450	c.211G>C	c.(211-213)GAT>CAT	p.D71H	DOCK10_uc002vob.2_Missense_Mutation_p.D65H|DOCK10_uc002vod.1_Missense_Mutation_p.D71H	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	71							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AACAAGAGATCTTGAAGAGGA	0.428													0	0	0	0.00308	0	7	18										G	225796298	C	G	225796298	3	3	113	1	0	0	0	0	1	0	0	0	4685	913	32	1	6569	1	DOCK10	2	225796298	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	18624537	225796298	17403075	32	34228										
COL6A3	1293	broad.mit.edu	37	chr2	238305397	238305397	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctgctgctgggcatgagttgTaggaaagcctgagagaaaga	15	6	0	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:238305397T>C	uc002vwl.2	-	2	349	c.64A>G	c.(64-66)ACA>GCA	p.T22A	COL6A3_uc002vwo.2_Missense_Mutation_p.T22A|COL6A3_uc010znj.1_Missense_Mutation_p.T22A|COL6A3_uc002vwq.2_Missense_Mutation_p.T22A|COL6A3_uc002vwr.2_Missense_Mutation_p.T22A|COL6A3_uc010znk.1_Missense_Mutation_p.T22A	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	22					axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCATGAGTTGTAGGAAAGCCT	0.418													0	0	0	0.01441	0	54	89										C	238305397	T	C	238305397	3	2	113	1	0	0	0	0	1	0	0	0	3701	1638	57	5	9688	5	COL6A3	2	238305397	Missense_Mutation	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	12509099	238305397	4893976	33	34229										
ANKMY1	51281	broad.mit.edu	37	chr2	241421610	241421610	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	acacacttactgcccctgctCcttcacatccaggcccctgg	6	19	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:241421610C>A	uc002vyz.1	-	15	2837	c.2608G>T	c.(2608-2610)GAG>TAG	p.E870*	ANKMY1_uc002vza.1_Nonsense_Mutation_p.E646*|ANKMY1_uc010fzd.1_Nonsense_Mutation_p.E959*|ANKMY1_uc002vzb.1_Nonsense_Mutation_p.E631*|ANKMY1_uc002vzc.1_Nonsense_Mutation_p.E649*|ANKMY1_uc002vzd.1_Nonsense_Mutation_p.E693*	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	870							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TGCCCCTGCTCCTTCACATCC	0.612													1	0	1.30998e-17	0.005524	1.41649e-17	34	70										A	241421610	C	A	241421610	4	1	113	1	0	0	0	0	0	1	0	0	634	864	30	3	229	3	ANKMY1	2	241421610	Nonsense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	3116213	241421610	1777763	34	34230										
PASK	23178	broad.mit.edu	37	chr2	242082263	242082263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ggtcattaccagagagcgctGtcctgctctggcagagtctg	13	11	3	2	rs144572631		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:242082263G>A	uc002wao.1	-	2	277	c.185C>T	c.(184-186)ACA>ATA	p.T62I	PASK_uc010zol.1_Nonsense_Mutation_p.Q11*|PASK_uc010zom.1_Missense_Mutation_p.T62I|PASK_uc010fzl.1_Missense_Mutation_p.T62I|PASK_uc010zon.1_Intron|PASK_uc002waq.2_Missense_Mutation_p.T62I	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	62					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		AGAGAGCGCTGTCCTGCTCTG	0.562													0	0	0	0.009096	0	4	50										A	242082263	G	A	242082263	3	1	113	1	0	0	0	0	1	0	0	0	11472	1377	48	2	3854	2	PASK	2	242082263	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	660653	242082263	1117110	35	34231										
TGM4	7047	broad.mit.edu	37	chr3	44943289	44943289	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccctggatcatttcagtgctGagagcgttgggcatcccagc	12	12	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:44943289G>C	uc003coc.3	+	8	910	c.837G>C	c.(835-837)CTG>CTC	p.L279L		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	279					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TTTCAGTGCTGAGAGCGTTGG	0.587													0	0	0	0.003163	0	15	33										C	44943289	G	C	44943289	2	2	113	1	0	0	0	0	0	0	0	1	15829	1277	45	1		1	TGM4	3	44943289	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		44943289	153079141	36	34232										
SETD2	29072	broad.mit.edu	37	chr3	47147508	47147508	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcatcattcttcagggccatGaaatagtaatggatgttttt	8	6	4	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:47147508G>A	uc003cqs.2	-	6	4871	c.4818C>T	c.(4816-4818)TTC>TTT	p.F1606F	SETD2_uc003cqv.2_Silent_p.F1595F	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1606	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCAGGGCCATGAAATAGTAAT	0.378			N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.01441	0	55	130										A	47147508	G	A	47147508	2	1	113	1	0	0	0	0	0	0	0	1	14131	1281	45	1		1	SETD2	3	47147508	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2204219	47147508	150874922	37	34233										
ROBO1	6091	broad.mit.edu	37	chr3	78676636	78676636	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gaacagggggagtggggcctCgttcatcttcctcctcttct	12	12	4	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:78676636C>T	uc003dqe.2	-	26	3918	c.3710G>A	c.(3709-3711)CGA>CAA	p.R1237Q	ROBO1_uc003dqb.2_Missense_Mutation_p.R1198Q|ROBO1_uc003dqc.2_Missense_Mutation_p.R1137Q|ROBO1_uc003dqd.2_Missense_Mutation_p.R1192Q|ROBO1_uc010hoh.2_Missense_Mutation_p.R429Q|ROBO1_uc011bgl.1_Missense_Mutation_p.R809Q	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1237	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGTGGGGCCTCGTTCATCTTC	0.507													0	0	0	0.00499	0	18	28										T	78676636	C	T	78676636	3	4	113	1	0	0	0	0	1	0	0	0	13513	884	31	1	1269	1	ROBO1	3	78676636	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	31529128	78676636	119345794	38	34234										
TFG	10342	broad.mit.edu	37	chr3	100463742	100463742	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agcagccgcaggctccacctCagcagcctcaacagtatggt	10	15	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:100463742C>T	uc003due.2	+	7	1236	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	TFG_uc003duf.2_Nonsense_Mutation_p.Q263*|TFG_uc003dug.2_Nonsense_Mutation_p.Q259*|TFG_uc003duh.2_Nonsense_Mutation_p.Q259*|TFG_uc003dui.2_Nonsense_Mutation_p.Q263*	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	263					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						GGCTCCACCTCAGCAGCCTCA	0.463			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	0.01441	0	49	112										T	100463742	C	T	100463742	4	4	113	1	0	0	0	0	0	1	0	0	15803	827	29	1	809	1	TFG	3	100463742	Nonsense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	21787106	100463742	97558688	39	34235										
EEFSEC	60678	broad.mit.edu	37	chr3	128060617	128060617	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cattcacaccaacacgtgccGgctagccttccatggcatcc	7	17	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:128060617G>T	uc003eki.2	+	5	1366	c.1328G>T	c.(1327-1329)CGG>CTG	p.R443L	EEFSEC_uc003ekj.2_Missense_Mutation_p.R388L	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	443						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						AACACGTGCCGGCTAGCCTTC	0.602													1	0	2.74695e-27	0.01441	3.04454e-27	47	73										T	128060617	G	T	128060617	3	4	113	1	0	0	0	0	1	0	0	0	4931	1116	39	4	1346	4	EEFSEC	3	128060617	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	27596875	128060617	69961813	40	34236										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	38	10										G	1803568	C	G	1803568	3	3	113	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		1803568	189350708	41	34237										
FGFR3	2261	broad.mit.edu	37	chr4	1805533	1805533	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gcaattctattgggttttctCatcactctgcgtggctggtg	11	9	4	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1805533C>T	uc003gdr.3	+	8	1301	c.1045C>T	c.(1045-1047)CAT>TAT	p.H349Y	FGFR3_uc003gdu.2_Intron|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.H349Y|FGFR3_uc010icb.1_Missense_Mutation_p.H157Y|FGFR3_uc003gdt.1_Missense_Mutation_p.H178Y	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	349	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TGGGTTTTCTCATCACTCTGC	0.612		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	96	30										T	1805533	C	T	1805533	3	4	113	1	0	0	0	0	1	0	0	0	5867	826	29	1	1226	1	FGFR3	4	1805533	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	1965	1805533	189348743	42	34238										
FGFR3	2261	broad.mit.edu	37	chr4	1806112	1806112	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agtgtgtatgcaggcatcctCagctacggggtgggcttctt	14	9	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1806112C>T	uc003gdr.3	+	9	1387	c.1131C>T	c.(1129-1131)CTC>CTT	p.L377L	FGFR3_uc003gdu.2_Silent_p.L379L|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Silent_p.L377L	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	377	Helical; (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.L377L(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CAGGCATCCTCAGCTACGGGG	0.687		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	334	70										T	1806112	C	T	1806112	2	4	113	1	0	0	0	0	0	0	0	1	5867	813	29	1		1	FGFR3	4	1806112	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	579	1806112	189348164	43	34239										
C4orf21	55345	broad.mit.edu	37	chr4	113545020	113545020	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	caaacatgctcctttgtcatCatataaaattgcctgtatga	5	9	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:113545020C>G	uc003iau.2	-	4	326	c.115G>C	c.(115-117)GAT>CAT	p.D39H	C4orf21_uc003iaw.2_Missense_Mutation_p.D39H	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		CCTTTGTCATCATATAAAATT	0.254													0	0	0	0.009718	0	39	9										G	113545020	C	G	113545020	3	3	113	1	0	0	0	0	1	0	0	0	2254	826	29	1	6299	1	C4orf21	4	113545020	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	111738908	113545020	77609256	44	34240										
SH3RF1	57630	broad.mit.edu	37	chr4	170038745	170038745	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gcaacaagaccttagcctgaGgacttgtctggatgtgagct	12	9	1	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:170038745G>C	uc003isa.1	-	9	2041	c.1706C>G	c.(1705-1707)CCT>CGT	p.P569R	SH3RF1_uc010irc.1_Missense_Mutation_p.P269R	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	569						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CTTAGCCTGAGGACTTGTCTG	0.582													0	0	0	0.01441	0	79	89										C	170038745	G	C	170038745	3	2	113	1	0	0	0	0	1	0	0	0	14258	1000	35	4	976	4	SH3RF1	4	170038745	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	56493725	170038745	21115531	45	34241			1	156		3	3	159	G		4.918131e-07
SH3RF1	57630	broad.mit.edu	37	chr4	170038769	170038769	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ttgtctggatgtgagctgctGataccacagctgcggggaca	14	9	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:170038769G>A	uc003isa.1	-	9	2017	c.1682C>T	c.(1681-1683)TCA>TTA	p.S561L	SH3RF1_uc010irc.1_Missense_Mutation_p.S261L	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	561						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		GTGAGCTGCTGATACCACAGC	0.587													0	0	0	0.01441	0	74	90										A	170038769	G	A	170038769	3	1	113	1	0	0	0	0	1	0	0	0	14258	1294	45	1	1000	1	SH3RF1	4	170038769	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	24	170038769	21115507	46	34242			1	156		3	3	159	G		4.918131e-07
SH3RF1	57630	broad.mit.edu	37	chr4	170038903	170038903	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tggccagctgtagacataggGactttagcttgggaagcatt	13	7	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:170038903G>A	uc003isa.1	-	9	1883	c.1548C>T	c.(1546-1548)GTC>GTT	p.V516V	SH3RF1_uc010irc.1_Silent_p.V216V	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	516	Interaction with AKT2 (By similarity).					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TAGACATAGGGACTTTAGCTT	0.527													0	0	0	0.005443	0	26	38										A	170038903	G	A	170038903	2	1	113	1	0	0	0	0	0	0	0	1	14258	1161	41	1		1	SH3RF1	4	170038903	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	134	170038903	21115373	47	34243			1	156		3	3	159	G		4.918131e-07
KIAA1430	57587	broad.mit.edu	37	chr4	186111756	186111756	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttagatgacggagacgaatCagatagatggctatcagacc	11	8	2	6			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:186111756C>T	uc003ixf.3	-	2	742	c.595G>A	c.(595-597)GAT>AAT	p.D199N	KIAA1430_uc003ixg.2_Missense_Mutation_p.D199N	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	199	Ser-rich.										0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		GGAGACGAATCAGATAGATGG	0.318													0	0	0	0.00499	0	18	4										T	186111756	C	T	186111756	3	4	113	1	0	0	0	0	1	0	0	0	8232	826	29	1	1019	1	KIAA1430	4	186111756	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	16072853	186111756	5042520	48	34244										
TRIML1	339976	broad.mit.edu	37	chr4	189061706	189061706	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aactccaggaaatcctgaatCttttgcgtgtaaggagaaag	10	7	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:189061706C>G	uc003izm.1	+	2	548	c.433C>G	c.(433-435)CTT>GTT	p.L145V		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	145	Potential.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AATCCTGAATCTTTTGCGTGT	0.478													0	0	0	0.01441	0	100	34										G	189061706	C	G	189061706	3	3	113	1	0	0	0	0	1	0	0	0	16547	913	32	1	439	1	TRIML1	4	189061706	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	2949950	189061706	2092570	49	34245										
ADAMTS16	170690	broad.mit.edu	37	chr5	5237159	5237159	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgtcaaataaagtcaaagatGggactccatgctcggaggat	11	7	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:5237159G>A	uc003jdl.2	+	14	2239	c.2101G>A	c.(2101-2103)GGG>AGG	p.G701R	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G701R|ADAMTS16_uc010itk.1_Intron	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	701	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGTCAAAGATGGGACTCCATG	0.308													0	0	0	0.007835	0	42	96										A	5237159	G	A	5237159	3	1	113	1	0	0	0	0	1	0	0	0	261	1348	47	2	2155	2	ADAMTS16	5	5237159	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		5237159	175678101	50	34246										
RAI14	26064	broad.mit.edu	37	chr5	34823332	34823332	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	acaggtcgaactccaatcccGaagggcagaactggtatgct	11	11	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:34823332G>C	uc003jir.2	+	15	1581	c.1385G>C	c.(1384-1386)CGA>CCA	p.R462P	RAI14_uc010iur.2_Missense_Mutation_p.R433P|RAI14_uc011coj.1_Missense_Mutation_p.R462P|RAI14_uc003jis.2_Missense_Mutation_p.R465P|RAI14_uc003jit.2_Missense_Mutation_p.R462P|RAI14_uc011cok.1_Missense_Mutation_p.R454P	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	462	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CTCCAATCCCGAAGGGCAGAA	0.443													0	0	0	0.005524	0	37	67										C	34823332	G	C	34823332	3	2	113	1	0	0	0	0	1	0	0	0	13008	1058	37	1	1504	1	RAI14	5	34823332	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	29586173	34823332	146091928	51	34247			2	157		3	3	1055	G		2.192193e-05
RAI14	26064	broad.mit.edu	37	chr5	34823439	34823439	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aatacgaggaggctatgaaaGaagtccttagtgtgcagaag	13	5	0	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:34823439G>C	uc003jir.2	+	15	1688	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q	RAI14_uc010iur.2_Missense_Mutation_p.E469Q|RAI14_uc011coj.1_Missense_Mutation_p.E498Q|RAI14_uc003jis.2_Missense_Mutation_p.E501Q|RAI14_uc003jit.2_Missense_Mutation_p.E498Q|RAI14_uc011cok.1_Missense_Mutation_p.E490Q	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	498	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					GGCTATGAAAGAAGTCCTTAG	0.438													0	0	0	0.006999	0	37	49										C	34823439	G	C	34823439	3	2	113	1	0	0	0	0	1	0	0	0	13008	943	33	1	1611	1	RAI14	5	34823439	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	107	34823439	146091821	52	34248			2	157		3	3	1055	G		2.192193e-05
RAI14	26064	broad.mit.edu	37	chr5	34824386	34824386	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ttaaaggaatctgtgaaagaGaaagagaaggtccattcaga	11	4	2	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:34824386G>C	uc003jir.2	+	15	2635	c.2439G>C	c.(2437-2439)GAG>GAC	p.E813D	RAI14_uc010iur.2_Missense_Mutation_p.E784D|RAI14_uc011coj.1_Missense_Mutation_p.E813D|RAI14_uc003jis.2_Missense_Mutation_p.E816D|RAI14_uc003jit.2_Missense_Mutation_p.E813D|RAI14_uc011cok.1_Missense_Mutation_p.E805D	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	813	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CTGTGAAAGAGAAAGAGAAGG	0.413													0	0	0	0.01441	0	60	128										C	34824386	G	C	34824386	3	2	113	1	0	0	0	0	1	0	0	0	13008	933	33	1	2558	1	RAI14	5	34824386	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	947	34824386	146090874	53	34249			2	157		3	3	1055	G		2.192193e-05
C5orf42	65250	broad.mit.edu	37	chr5	37173929	37173929	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	caatctggtaactgagccgtGaattcatttctctgggtctt	9	9	4	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:37173929G>A	uc011cpa.1	-	32	6330	c.6099C>T	c.(6097-6099)TTC>TTT	p.F2033F	C5orf42_uc011coy.1_Silent_p.F533F|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.F1108F|C5orf42_uc003jkr.1_Silent_p.F66F	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2033										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACTGAGCCGTGAATTCATTTC	0.403													0	0	0	0.01441	0	64	91										A	37173929	G	A	37173929	2	1	113	1	0	0	0	0	0	0	0	1	2301	1281	45	1		1	C5orf42	5	37173929	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2349543	37173929	143741331	54	34250										
GDNF	2668	broad.mit.edu	37	chr5	37816164	37816164	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgtttatctggtgaccttttCagtcttttaatggtggcttg	10	6	3	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:37816164C>T	uc011cpi.1	-	3	425	c.225G>A	c.(223-225)CTG>CTA	p.L75L	GDNF_uc011cpc.1_Intron|GDNF_uc011cpd.1_Silent_p.L23L|GDNF_uc011cpe.1_Silent_p.L49L|GDNF_uc011cpf.1_Silent_p.L49L|GDNF_uc011cpg.1_Silent_p.L92L|GDNF_uc011cph.1_Silent_p.L66L	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	75					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					GTGACCTTTTCAGTCTTTTAA	0.438													0	0	0	0.00874	0	41	89										T	37816164	C	T	37816164	2	4	113	1	0	0	0	0	0	0	0	1	6322	813	29	1		1	GDNF	5	37816164	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	642235	37816164	143099096	55	34251										
NNT	23530	broad.mit.edu	37	chr5	43628317	43628317	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cctagagctgcagctttggaAcagttcaagtctcttggtgc	11	10	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:43628317A>G	uc003joe.2	+	7	1047	c.792A>G	c.(790-792)GAA>GAG	p.E264E	NNT_uc003jof.2_Silent_p.E264E	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	264	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAGCTTTGGAACAGTTCAAGT	0.413													0	0	0	0.01441	0	72	138										G	43628317	A	G	43628317	2	3	113	1	0	0	0	0	0	0	0	1	10510	40	2	5		5	NNT	5	43628317	Silent	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	5812153	43628317	137286943	56	34252										
SKIV2L2	23517	broad.mit.edu	37	chr5	54640370	54640370	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccttgtcatgttatttacacAgattatcggcccactccatt	5	12	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:54640370A>G	uc003jpy.3	+	9	1193	c.927A>G	c.(925-927)ACA>ACG	p.T309T	SKIV2L2_uc011cqi.1_Silent_p.T208T	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	309					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTATTTACACAGATTATCGGC	0.348													0	0	0	0.007413	0	16	35										G	54640370	A	G	54640370	2	3	113	1	0	0	0	0	0	0	0	1	14360	175	7	5		5	SKIV2L2	5	54640370	Silent	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	11012053	54640370	126274890	57	34253										
POC5	134359	broad.mit.edu	37	chr5	74984960	74984960	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	atgttgcattctttgaatctCagcttttgcattttccaaag	6	8	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:74984960C>T	uc003keh.3	-	9	1203	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	POC5_uc010izu.2_Missense_Mutation_p.E219K|POC5_uc003keg.3_Missense_Mutation_p.E311K	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	336	Potential.				cell cycle	centriole				lung(1)	1						CTTTGAATCTCAGCTTTTGCA	0.308													0	0	0	0.000602	0	5	11										T	74984960	C	T	74984960	3	4	113	1	0	0	0	0	1	0	0	0	12177	835	29	1	737	1	POC5	5	74984960	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	20344590	74984960	105930300	58	34254										
RASA1	5921	broad.mit.edu	37	chr5	86670043	86670043	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagtaaaacattttactaatCcatattgtaacatctacctg	3	9	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:86670043C>T	uc003kiw.2	+	14	1958	c.1840C>T	c.(1840-1842)CCA>TCA	p.P614S	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.P437S|RASA1_uc011ctv.1_Missense_Mutation_p.P447S|RASA1_uc011ctw.1_Missense_Mutation_p.P448S|RASA1_uc010jaw.2_Missense_Mutation_p.P436S	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	614	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TTTTACTAATCCATATTGTAA	0.338													0	0	0	0.004656	0	27	30										T	86670043	C	T	86670043	3	4	113	1	0	0	0	0	1	0	0	0	13060	855	30	1	1906	1	RASA1	5	86670043	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	11685083	86670043	94245217	59	34255										
C5orf48	389320	broad.mit.edu	37	chr5	125967431	125967431	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tccattgctgtcaggaatggCttcagggaaagatacttgtc	11	8	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:125967431C>A	uc003kub.1	+	1	18	c.5C>A	c.(4-6)GCT>GAT	p.A2D		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	2										ovary(1)	1						TCAGGAATGGCTTCAGGGAAA	0.378													1	0	4.7796e-09	0.004656	4.98578e-09	25	76										A	125967431	C	A	125967431	3	1	113	1	0	0	0	0	1	0	0	0	2306	797	28	4	7	4	C5orf48	5	125967431	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	39297388	125967431	54947829	60	34256										
C5orf48	389320	broad.mit.edu	37	chr5	125967495	125967495	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aactgctctgatgagagtctCtataaatctgctaataagta	7	7	3	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:125967495C>G	uc003kub.1	+	1	82	c.69C>G	c.(67-69)CTC>CTG	p.L23L		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	23										ovary(1)	1						ATGAGAGTCTCTATAAATCTG	0.398													0	0	0	0.007291	0	27	66										G	125967495	C	G	125967495	2	3	113	1	0	0	0	0	0	0	0	1	2306	900	32	1		1	C5orf48	5	125967495	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	64	125967495	54947765	61	34257										
FBN2	2201	broad.mit.edu	37	chr5	127654607	127654607	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgttctgtccaattcataacCatcatcgcagatgcaatgaa	6	10	3	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:127654607C>T	uc003kuu.2	-	35	4997	c.4558G>A	c.(4558-4560)GGT>AGT	p.G1520S		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1520	EGF-like 25; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AATTCATAACCATCATCGCAG	0.378													0	0	0	0.005443	0	29	83										T	127654607	C	T	127654607	3	4	113	1	0	0	0	0	1	0	0	0	5703	594	21	2	4304	2	FBN2	5	127654607	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	1687112	127654607	53260653	62	34258										
PCDHGA5	56110	broad.mit.edu	37	chr5	140744002	140744002	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gggcagatccgctactcgatGccggaggagctggacaaagg	16	10	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:140744002G>A	uc003lju.1	+	1	105	c.105G>A	c.(103-105)ATG>ATA	p.M35I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.M35I	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	35	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTACTCGATGCCGGAGGAGC	0.667													0	0	0	0.003954	0	27	37										A	140744002	G	A	140744002	3	1	113	1	0	0	0	0	1	0	0	0	11557	1319	46	2	107	2	PCDHGA5	5	140744002	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	13089395	140744002	40171258	63	34259										
FAM193B	54540	broad.mit.edu	37	chr5	176951275	176951275	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tctgtggccttgctgggcctGagggctgcacagactcctgc	14	13	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:176951275G>A	uc003mhs.3	-	8	3697	c.2108C>T	c.(2107-2109)CCA>CTA	p.P703L	FAM193B_uc003mhr.2_Missense_Mutation_p.S240L|FAM193B_uc003mht.2_Missense_Mutation_p.S362L|FAM193B_uc003mhu.2_Missense_Mutation_p.S415L|FAM193B_uc003mhv.2_Missense_Mutation_p.S362L|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						TGCTGGGCCTGAGGGCTGCAC	0.667													0	0	0	0.000602	0	5	5										A	176951275	G	A	176951275	3	1	113	1	0	0	0	0	1	0	0	0	5525	1294	45	1	273	1	FAM193B	5	176951275	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	36207273	176951275	3963985	64	34260										
CANX	821	broad.mit.edu	37	chr5	179151700	179151700	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ataagaaaactgatgcacctCaaccggatgtgaaggaagag	11	7	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:179151700C>T	uc003mkk.2	+	13	1738	c.1561C>T	c.(1561-1563)CAA>TAA	p.Q521*	CANX_uc011dgp.1_Nonsense_Mutation_p.Q556*|CANX_uc003mkl.2_Nonsense_Mutation_p.Q521*|CANX_uc011dgq.1_Nonsense_Mutation_p.Q413*	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	521	Cytoplasmic (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGATGCACCTCAACCGGATGT	0.239													0	0	0	0.00623	0	38	74										T	179151700	C	T	179151700	4	4	113	1	0	0	0	0	0	1	0	0	2618	827	29	1	1607	1	CANX	5	179151700	Nonsense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	2200425	179151700	1763560	65	34261										
VARS	7407	broad.mit.edu	37	chr6	31760563	31760563	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gagagagaggcctggctcctGagtatagaaccacttctcct	11	11	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:31760563G>A	uc003nxe.2	-	4	1055	c.632C>T	c.(631-633)TCA>TTA	p.S211L	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	211	GST C-terminal.				translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CCTGGCTCCTGAGTATAGAAC	0.562													0	0	0	0.01441	0	68	25										A	31760563	G	A	31760563	3	1	113	1	0	0	0	0	1	0	0	0	17120	1294	45	1	3270	1	VARS	6	31760563	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		31760563	139354504	66	34262										
GPR110	266977	broad.mit.edu	37	chr6	46977913	46977913	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccgagaaaaattcagaggaaGagctgtcggaggcaccagag	14	8	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:46977913G>C	uc003oyt.2	-	11	1457	c.1258C>G	c.(1258-1260)CTT>GTT	p.L420V	GPR110_uc011dwl.1_Missense_Mutation_p.L108V	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	420	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TTCAGAGGAAGAGCTGTCGGA	0.438													0	0	0	0.010818	0	32	103										C	46977913	G	C	46977913	3	2	113	1	0	0	0	0	1	0	0	0	6627	942	33	1	1494	1	GPR110	6	46977913	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	15217350	46977913	124137154	67	34263										
PRIM2	5558	broad.mit.edu	37	chr6	57512667	57512667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cctctctggaaatggatatgGaaggactagaggattacttt	11	6	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:57512667G>A	uc003pdx.2	+	15	1582	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	499					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		AATGGATATGGAAGGACTAGA	0.388													0	0	0	0.01441	0	70	620										A	57512667	G	A	57512667	3	1	113	1	0	0	0	0	1	0	0	0	12491	1175	41	1	1545	1	PRIM2	6	57512667	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	10534754	57512667	113602400	68	34264										
ANKRD6	22881	broad.mit.edu	37	chr6	90327727	90327727	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	acaataacccggaagttgctCttctccttactaaagctccc	5	14	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:90327727C>G	uc003pni.3	+	9	1110	c.769C>G	c.(769-771)CTT>GTT	p.L257V	ANKRD6_uc003pne.3_Missense_Mutation_p.L257V|ANKRD6_uc003pnf.3_Missense_Mutation_p.L257V|ANKRD6_uc011dzy.1_Missense_Mutation_p.L257V|ANKRD6_uc010kcd.2_Intron|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	257	ANK 8.						protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		GGAAGTTGCTCTTCTCCTTAC	0.542													0	0	0	0.01441	0	65	47										G	90327727	C	G	90327727	3	3	113	1	0	0	0	0	1	0	0	0	685	913	32	1	799	1	ANKRD6	6	90327727	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	32815060	90327727	80787340	69	34265										
C6orf182	285753	broad.mit.edu	37	chr6	109471320	109471320	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgaataccctttatttcataGatataagtatacagttaagc	5	6	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:109471320G>C	uc010kdk.2	+	6	918	c.341_splice	c.e6-1	p.D114_splice	C6orf182_uc003psv.3_Intron|C6orf182_uc003psw.3_Splice_Site_p.D114_splice|C6orf182_uc003psx.3_Splice_Site_p.D114_splice|C6orf182_uc010kdl.2_Splice_Site_p.D114_splice|C6orf182_uc003psy.3_Splice_Site_p.D114_splice	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753							microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		ttatttcATAGATATAAGTAT	0.194													0	0	0	0.01441	0	55	25										C	109471320	G	C	109471320	5	2	113	1	0	0	0	0	0	0	1	0	2346	956	33	1	350	1	C6orf182	6	109471320	Splice_Site	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	19143593	109471320	61643747	70	34266										
PMS2	5395	broad.mit.edu	37	chr7	6045538	6045538	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttaccaatattagtggcacCagcatccagactgttttcta	6	11	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:6045538C>G	uc003spl.2	-	2	235	c.148G>C	c.(148-150)GGT>CGT	p.G50R	PMS2_uc003spj.2_5'Flank|PMS2_uc003spk.2_5'UTR|PMS2_uc011jwl.1_Intron|PMS2_uc010ktg.2_5'UTR|PMS2_uc010kte.2_Missense_Mutation_p.G50R|PMS2_uc010ktf.1_Missense_Mutation_p.G50R	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	50					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TTAGTGGCACCAGCATCCAGA	0.398			Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.01441	0	175	379										G	6045538	C	G	6045538	3	3	113	1	0	0	0	0	1	0	0	0	12143	594	21	4	2496	4	PMS2	7	6045538	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		6045538	153093125	71	34267										
TMEM195	392636	broad.mit.edu	37	chr7	15430465	15430465	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ttttaatacattttacttacCaaaaattttatcccaaataa	0	7	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:15430465C>T	uc003stb.1	-	7	912	c.742G>A	c.(742-744)GGG>AGG	p.G248R		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	248					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TTTTACTTACCAAAAATTTTA	0.264													0	0	0	0.007291	0	29	43										T	15430465	C	T	15430465	3	4	113	1	0	0	0	0	1	0	0	0	16114	608	21	2	623	2	TMEM195	7	15430465	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	9384927	15430465	143708198	72	34268										
AGR3	155465	broad.mit.edu	37	chr7	16913467	16913467	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aagtgatgtcatctccccatCctgaaatagaagagagaaat	8	8	2	5			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:16913467C>T	uc003sts.2	-	3	183	c.110G>A	c.(109-111)GGA>GAA	p.G37E		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	37						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		ATCTCCCCATCCTGAAATAGA	0.353													0	0	0	0.007291	0	26	47										T	16913467	C	T	16913467	3	4	113	1	0	0	0	0	1	0	0	0	396	869	30	1	414	1	AGR3	7	16913467	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	1483002	16913467	142225196	73	34269										
DFNA5	1687	broad.mit.edu	37	chr7	24784190	24784190	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agtctccttacctctcggcaGagtctctgatgagctgctgc	10	13	3	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:24784190G>C	uc010kus.1	-	3	483	c.395C>G	c.(394-396)TCT>TGT	p.S132C	DFNA5_uc003swz.2_5'UTR|DFNA5_uc003sxa.1_Missense_Mutation_p.S132C|DFNA5_uc010kut.1_5'UTR|DFNA5_uc003sxb.2_Missense_Mutation_p.S132C|DFNA5_uc003sxc.2_Missense_Mutation_p.S132C	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	132					sensory perception of sound					ovary(1)	1						CCTCTCGGCAGAGTCTCTGAT	0.493													0	0	0	0.01441	0	59	73										C	24784190	G	C	24784190	3	2	113	1	0	0	0	0	1	0	0	0	4454	942	33	1	1127	1	DFNA5	7	24784190	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	7870723	24784190	134354473	74	34270										
OSBPL3	26031	broad.mit.edu	37	chr7	24856260	24856260	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cacatgggttgtgccaattgGaacaatttccatggatttgc	10	8	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:24856260G>A	uc003sxf.2	-	18	2401	c.1996C>T	c.(1996-1998)CCA>TCA	p.P666S	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.P630S|OSBPL3_uc003sxh.2_Missense_Mutation_p.P635S|OSBPL3_uc003sxi.2_Missense_Mutation_p.P599S	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	666					lipid transport		lipid binding|protein binding			skin(1)	1						GTGCCAATTGGAACAATTTCC	0.398													0	0	0	0.01441	0	74	116										A	24856260	G	A	24856260	3	1	113	1	0	0	0	0	1	0	0	0	11279	1174	41	1	691	1	OSBPL3	7	24856260	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	72070	24856260	134282403	75	34271										
AKAP9	10142	broad.mit.edu	37	chr7	91603051	91603051	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagtttcgacaaagaaaagcTcagtcggatgggcagagtcc	12	9	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:91603051T>C	uc003ulg.2	+	2	300	c.75T>C	c.(73-75)GCT>GCC	p.A25A	AKAP9_uc003uld.3_Silent_p.A25A|AKAP9_uc003ule.2_Silent_p.A37A|AKAP9_uc003ulf.2_Silent_p.A25A	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	37					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAGAAAAGCTCAGTCGGATG	0.368			T	BRAF	papillary thyroid								0	0	0	0.008871	0	17	34										C	91603051	T	C	91603051	2	2	113	1	0	0	0	0	0	0	0	1	459	1538	54	5		5	AKAP9	7	91603051	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	66746791	91603051	67535612	76	34272										
ZNF394	84124	broad.mit.edu	37	chr7	99096378	99096378	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ggaatccttctgcgcactctCtctgcagaagtccctccgtg	9	15	3	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:99096378C>T	uc003uqs.2	-	2	705	c.544G>A	c.(544-546)GAG>AAG	p.E182K	ZNF394_uc003uqt.2_Intron|ZNF394_uc003uqu.1_Missense_Mutation_p.E182K	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	182	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGCGCACTCTCTCTGCAGAAG	0.577													0	0	0	0.010504	0	20	44										T	99096378	C	T	99096378	3	4	113	1	0	0	0	0	1	0	0	0	17877	922	32	1	1149	1	ZNF394	7	99096378	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	7493327	99096378	60042285	77	34273										
MLL5	55904	broad.mit.edu	37	chr7	104753361	104753361	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagcacccccaccaccccctCcgccgccaccttccagtgtt	5	24	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:104753361C>G	uc003vcm.2	+	27	5692	c.5158C>G	c.(5158-5160)CCG>GCG	p.P1720A	MLL5_uc010ljc.2_Missense_Mutation_p.P1720A|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.P454A	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1720	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACCACCCCCTCCGCCGCCACC	0.552													0	0	0	0.00874	0	41	46										G	104753361	C	G	104753361	3	3	113	1	0	0	0	0	1	0	0	0	9624	855	30	1	5256	1	MLL5	7	104753361	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	5656983	104753361	54385302	78	34274										
SLC26A4	5172	broad.mit.edu	37	chr7	107335098	107335098	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gctgttgtaattgccaacctGaaagggatgtttatgcagct	11	7	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:107335098G>T	uc003vep.2	+	12	1598	c.1374G>T	c.(1372-1374)CTG>CTT	p.L458L	SLC26A4_uc011kmb.1_Silent_p.L45L|SLC26A4_uc011kmc.1_Silent_p.L19L|SLC26A4_uc011kmd.1_Silent_p.L27L	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	458	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						TTGCCAACCTGAAAGGGATGT	0.418									Pendred_syndrome				1	0	6.61955e-31	0.01441	7.42954e-31	40	75										T	107335098	G	T	107335098	2	4	113	1	0	0	0	0	0	0	0	1	14519	1277	45	3		3	SLC26A4	7	107335098	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2581737	107335098	51803565	79	34275										
FLNC	2318	broad.mit.edu	37	chr7	128470904	128470904	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agcgacgggctccggctcatCgcgctgctcgaggtgctcag	15	14	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:128470904C>T	uc003vnz.3	+	1	422	c.213C>T	c.(211-213)ATC>ATT	p.I71I	FLNC_uc003voa.3_Silent_p.I71I	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	71	CH 1.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCCGGCTCATCGCGCTGCTCG	0.637													0	0	0	0.003163	0	16	35										T	128470904	C	T	128470904	2	4	113	1	0	0	0	0	0	0	0	1	5935	874	31	1		1	FLNC	7	128470904	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	21135806	128470904	30667759	80	34276										
GIMAP8	155038	broad.mit.edu	37	chr7	150174632	150174632	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	actcagataacaaagcccttCggcgcatttttaaaaagtgt	7	9	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:150174632C>T	uc003whj.2	+	5	2092	c.1762C>T	c.(1762-1764)CGG>TGG	p.R588W		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	588						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAAAGCCCTTCGGCGCATTTT	0.463													0	0	0	0.01441	0	61	86										T	150174632	C	T	150174632	3	4	113	1	0	0	0	0	1	0	0	0	6385	875	31	1	1776	1	GIMAP8	7	150174632	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	21703728	150174632	8964031	81	34277										
SLC4A2	6522	broad.mit.edu	37	chr7	150767332	150767332	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagctggctccctgggctccCtgctggggcatcaccatggt	13	15	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:150767332C>T	uc003wit.3	+	10	1604	c.1348C>T	c.(1348-1350)CTG>TTG	p.L450L	SLC4A2_uc011kve.1_Silent_p.L441L|SLC4A2_uc003wiu.3_Silent_p.L436L|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	450	Cytoplasmic (Potential).			LLGHHHGQGAESDPHVTEPLMGGVPE -> CWGITMVRGLR VTPTSPSLSWEVFLR (in Ref. 6; CAA27556).	bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTGGGCTCCCTGCTGGGGCA	0.642													0	0	0	0.01441	0	46	72										T	150767332	C	T	150767332	2	4	113	1	0	0	0	0	0	0	0	1	14654	680	24	2		2	SLC4A2	7	150767332	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	592700	150767332	8371331	82	34278										
GALNT11	63917	broad.mit.edu	37	chr7	151791435	151791435	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagccacttaagaatgtgccCgtcaaggggtctgggcccca	12	13	2	1	rs138436495	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:151791435C>T	uc010lqg.1	+	2	353	c.123C>T	c.(121-123)CCC>CCT	p.P41P	GALNT11_uc011kvm.1_Intron|GALNT11_uc003wku.2_Silent_p.P41P|GALNT11_uc003wkv.1_Silent_p.P41P|GALNT11_uc011kvn.1_RNA	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	41	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		AGAATGTGCCCGTCAAGGGGT	0.473													0	0	0	0.013537	0	12	284										T	151791435	C	T	151791435	2	4	113	1	0	0	0	0	0	0	0	1	6209	639	23	2		2	GALNT11	7	151791435	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	1024103	151791435	7347228	83	34279										
CLDN23	137075	broad.mit.edu	37	chr8	8560467	8560467	+	Frame_Shift_Del	DEL	G	G	-													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gcttcgcgccctggtgcgacGagcgttgtcgccgccgccgc							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:8560467delG	uc003wsi.2	+	1	802	c.559delG	c.(559-561)GAGfs	p.E187fs		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	187	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CTGGTGCGACGAGCGTTGTCG	0.731																		9	6	---	---								-	8560467	G	-	8560467	7	5	113	1	0	1	0	1	0	0	0	0	3484	1059	37	0	561	0	CLDN23	8	8560467	Frame_Shift_Del	DEL	G	TCGA-GU-A42R-01A-11D-A23M-08		8560467	137803555	84	34280										
BMP1	649	broad.mit.edu	37	chr8	22052270	22052270	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	acagctgtgcctacgactatCtggaggtgcgcgacgggcac	14	12	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:22052270C>T	uc003xbg.2	+	12	1721	c.1477C>T	c.(1477-1479)CTG>TTG	p.L493L	BMP1_uc003xba.2_Silent_p.L493L|BMP1_uc003xbb.2_Silent_p.L493L|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.L242L|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.L242L|BMP1_uc011kzc.1_Silent_p.L242L|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	493	CUB 2.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		CTACGACTATCTGGAGGTGCG	0.617													0	0	0	0.003755	0	31	52										T	22052270	C	T	22052270	2	4	113	1	0	0	0	0	0	0	0	1	1456	912	32	1		1	BMP1	8	22052270	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	13491803	22052270	124311752	85	34281										
DDHD2	23259	broad.mit.edu	37	chr8	38095721	38095721	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agaacatctctgttgacattCattgtggtaatgttaatcgt	8	6	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:38095721C>A	uc003xlb.2	+	5	993	c.616C>A	c.(616-618)CAT>AAT	p.H206N	DDHD2_uc003xla.2_Missense_Mutation_p.H206N|DDHD2_uc003xlc.2_Missense_Mutation_p.H206N|DDHD2_uc011lbl.1_Intron	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	206					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TGTTGACATTCATTGTGGTAA	0.418													1	0	3.03874e-20	0.003271	3.2992e-20	32	63										A	38095721	C	A	38095721	3	1	113	1	0	0	0	0	1	0	0	0	4327	826	29	3	630	3	DDHD2	8	38095721	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	16043451	38095721	108268301	86	34282										
EIF3E	3646	broad.mit.edu	37	chr8	109240615	109240615	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agagactgaagtggagaactCacagactaaaggatttaaaa	10	5	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:109240615C>G	uc003ymu.2	-	7	631	c.603G>C	c.(601-603)GTG>GTC	p.V201V	EIF3E_uc003ymt.2_Silent_p.V152V|EIF3E_uc003ymv.2_Silent_p.V108V|EIF3E_uc010mci.1_Silent_p.V201V	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	201					negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			GTGGAGAACTCACAGACTAAA	0.328													0	0	0	0.004289	0	37	75										G	109240615	C	G	109240615	2	3	113	1	0	0	0	0	0	0	0	1	5015	813	29	1		1	EIF3E	8	109240615	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	71144894	109240615	37123407	87	34283										
OC90	729330	broad.mit.edu	37	chr8	133047065	133047065	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctagcagctcccactccttcCtgatcgtggcctgcttctgt	8	16	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:133047065C>T	uc003ytg.2	-	9	696	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	OC90_uc011lix.1_Silent_p.Q232Q	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	248					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CCACTCCTTCCTGATCGTGGC	0.567													0	0	0	0.01441	0	49	99										T	133047065	C	T	133047065	2	4	113	1	0	0	0	0	0	0	0	1	10814	680	24	2		2	OC90	8	133047065	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	23806450	133047065	13316957	88	34284										
FRMPD1	22844	broad.mit.edu	37	chr9	37746352	37746352	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	attttagaaacttcctggggGgttggaaacaaacatccccc	9	10	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr9:37746352G>A	uc004aag.1	+	16	4367	c.4323G>A	c.(4321-4323)GGG>GGA	p.G1441G	FRMPD1_uc004aah.1_Silent_p.G1441G	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1441						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CTTCCTGGGGGGTTGGAAACA	0.572													0	0	0	0.006214	0	10	19										A	37746352	G	A	37746352	2	1	113	1	0	0	0	0	0	0	0	1	6057	1219	43	2		2	FRMPD1	9	37746352	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		37746352	103467079	89	34285										
CDC14B	8555	broad.mit.edu	37	chr9	99381613	99381613	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gacgagcagcgccgcgagcaGgggggcgcggcggcccagct	20	14	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr9:99381613G>C	uc004awj.2	-	1	500	c.48C>G	c.(46-48)CCC>CCG	p.P16P	CDC14B_uc004awk.2_Silent_p.P16P|CDC14B_uc004awl.2_RNA	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	16	Nucleolar localization signal (Probable).				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCCGCGAGCAGGGGGGCGCGG	0.677													0	0	0	0.013537	0	12	5										C	99381613	G	C	99381613	2	2	113	1	0	0	0	0	0	0	0	1	3057	987	35	4		4	CDC14B	9	99381613	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	61635261	99381613	41831818	90	34286										
KIF12	113220	broad.mit.edu	37	chr9	116854869	116854869	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gggctgcatgggggtgcccaGggtgggggccgggcagatgg	24	8	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr9:116854869G>A	uc004bif.2	-	14	1474	c.1236C>T	c.(1234-1236)CCC>CCT	p.P412P	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	545	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGGGTGCCCAGGGTGGGGGCC	0.652													0	0	0	0.013537	0	11	5										A	116854869	G	A	116854869	2	1	113	1	0	0	0	0	0	0	0	1	8273	987	35	2		2	KIF12	9	116854869	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	17473256	116854869	24358562	91	34287										
KIAA1279	26128	broad.mit.edu	37	chr10	70765492	70765492	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tattttttctttacagatttGaaaaggtttatactcataac	4	5	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:70765492G>C	uc001joy.2	+	4	706	c.610G>C	c.(610-612)GAA>CAA	p.E204Q		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	204					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						TTACAGATTTGAAAAGGTTTA	0.209													0	0	0	0.00499	0	17	29										C	70765492	G	C	70765492	3	2	113	1	0	0	0	0	1	0	0	0	8221	1291	45	1	624	1	KIAA1279	10	70765492	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		70765492	64769255	92	34288										
PPP3CB	5532	broad.mit.edu	37	chr10	75239146	75239146	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagcaccctcattgataattCtaagcgcaatttcttcatct	4	12	5	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:75239146C>T	uc001jue.2	-	2	350	c.215G>A	c.(214-216)AGA>AAA	p.R72K	PPP3CB_uc001juf.2_Missense_Mutation_p.R72K|PPP3CB_uc001jug.2_Missense_Mutation_p.R72K|PPP3CB_uc001jui.2_Missense_Mutation_p.R72K|PPP3CB_uc001juh.2_5'UTR	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	72	Catalytic.									skin(1)	1	Prostate(51;0.0119)					ATTGATAATTCTAAGCGCAAT	0.403													0	0	0	0.01441	0	115	226										T	75239146	C	T	75239146	3	4	113	1	0	0	0	0	1	0	0	0	12398	913	32	1	1414	1	PPP3CB	10	75239146	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	4473654	75239146	60295601	93	34289										
COMTD1	118881	broad.mit.edu	37	chr10	76993951	76993951	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcggccgccacgtcccctttCggaggttgcagcaccttccc	10	18	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:76993951C>T	uc001jxb.2	-	7	753	c.669G>A	c.(667-669)CCG>CCA	p.P223P	COMTD1_uc001jxc.1_Missense_Mutation_p.E315K	NM_144589	NP_653190	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing	223						integral to membrane	O-methyltransferase activity				0	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					CGTCCCCTTTCGGAGGTTGCA	0.697													0	0	0	0.010818	0	26	54										T	76993951	C	T	76993951	2	4	113	1	0	0	0	0	0	0	0	1	3726	871	31	1		1	COMTD1	10	76993951	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	1754805	76993951	58540796	94	34290										
PDCD11	22984	broad.mit.edu	37	chr10	105169473	105169474	+	Frame_Shift_Ins	INS	-	-	A													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aggtgactccatttggccttINSacgctaaacttcctcacatt							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:105169473_105169474insA	uc001kwy.1	+	8	975_976	c.888_889insA	c.(886-891)CTTACGfs	p.L296fs		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	296_297	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CATTTGGCCTTACGCTAAACTT	0.391																		51	95	---	---								A	105169474	-	A	105169473	7	5	113	1	0	1	1	0	0	0	0	0	11617	1741	61	0	914	0	PDCD11	10	105169473	Frame_Shift_Ins	INS	-	TCGA-GU-A42R-01A-11D-A23M-08	28175522	105169473	30365274	95	34291										
SLC18A2	6571	broad.mit.edu	37	chr10	119013596	119013596	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agctatgccttcctgctgatTgccaggtcgctgcagggcat	12	12	0	1	rs11568720		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:119013596T>C	uc001ldd.1	+	5	592	c.561T>C	c.(559-561)ATT>ATC	p.I187I	SLC18A2_uc009xyy.1_5'UTR	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	187	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TCCTGCTGATTGCCAGGTCGC	0.607													0	0	0	0.01441	0	70	138										C	119013596	T	C	119013596	2	2	113	1	0	0	0	0	0	0	0	1	14426	1800	63	5		5	SLC18A2	10	119013596	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	13844123	119013596	16521151	96	34292										
NUP98	4928	broad.mit.edu	37	chr11	3704662	3704662	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agcagctctcgaacagccttCtcacgtatgctacagggaga	10	12	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:3704662C>T	uc001lyh.2	-	30	4977	c.4686G>A	c.(4684-4686)GAG>GAA	p.E1562E	NUP98_uc001lyi.2_Silent_p.E1488E|NUP98_uc001lyg.2_Silent_p.E527E	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1579					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GAACAGCCTTCTCACGTATGC	0.537			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.005524	0	34	17										T	3704662	C	T	3704662	2	4	113	1	0	0	0	0	0	0	0	1	10773	912	32	1		1	NUP98	11	3704662	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		3704662	131301854	97	34293										
SBF2	81846	broad.mit.edu	37	chr11	10022460	10022460	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	actttaaagatgaatacttaCaagttcatggacatcagttt	6	6	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:10022460C>T	uc001mib.2	-	8	999	c.861_splice	c.e8+1	p.L287_splice	SBF2_uc001mif.3_Splice_Site_p.L43_splice	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2						myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TGAATACTTACAAGTTCATGG	0.363													0	0	0	0.00333	0	24	13										T	10022460	C	T	10022460	5	4	113	1	0	0	0	0	0	0	1	0	13859	492	17	2	4819	2	SBF2	11	10022460	Splice_Site	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	6317798	10022460	124984056	98	34294										
OR4A15	81328	broad.mit.edu	37	chr11	55136137	55136137	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ttaagactcagagtttggaaGggaaacgaaaagctttctac	10	6	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:55136137G>A	uc010rif.1	+	1	778	c.778G>A	c.(778-780)GGG>AGG	p.G260R		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	260	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGTTTGGAAGGGAAACGAAA	0.428													0	0	0	0.01441	0	89	106										A	55136137	G	A	55136137	3	1	113	1	0	0	0	0	1	0	0	0	11040	1000	35	2	780	2	OR4A15	11	55136137	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	45113677	55136137	79870379	99	34295										
OR9G9	504191	broad.mit.edu	37	chr11	56468004	56468004	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aatagcaccctcatcgtgttGatctgtaatgactcctgcct	7	12	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:56468004G>T	uc010rjn.1	+	1	141	c.141G>T	c.(139-141)TTG>TTT	p.L47F		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATCGTGTTGATCTGTAATG	0.502													1	0	3.73148e-12	0.007291	3.95447e-12	18	99										T	56468004	G	T	56468004	3	4	113	1	0	0	0	0	1	0	0	0	11252	1281	45	3	143	3	OR9G9	11	56468004	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	1331867	56468004	78538512	100	34296										
SLC22A8	9376	broad.mit.edu	37	chr11	62763286	62763286	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tccttctgcaggttgagtttGagctccttcgggcagaggag	14	9	1	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:62763286G>C	uc001nwo.2	-	7	1027	c.891C>G	c.(889-891)CTC>CTG	p.L297L	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Silent_p.L297L|SLC22A8_uc009yom.2_Silent_p.L174L|SLC22A8_uc010rmm.1_Silent_p.L206L|SLC22A8_uc009yon.2_Silent_p.L297L	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	297	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GGTTGAGTTTGAGCTCCTTCG	0.582													0	0	0	0.01441	0	60	98										C	62763286	G	C	62763286	2	2	113	1	0	0	0	0	0	0	0	1	14460	1277	45	1		1	SLC22A8	11	62763286	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	6295282	62763286	72243230	101	34297										
MEN1	4221	broad.mit.edu	37	chr11	64571830	64571830	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aggcctttgcgctgccgcttGaggaaagacagagtgtagtc	14	9	0	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:64571830G>C	uc001obj.2	-	10	1897	c.1824C>G	c.(1822-1824)CTC>CTG	p.L608L	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Silent_p.L608L|MEN1_uc001obl.2_Silent_p.L568L|MEN1_uc001obm.2_Silent_p.L603L|MEN1_uc001obn.2_Silent_p.L608L|MEN1_uc001obo.2_Silent_p.L608L|MEN1_uc001obp.2_Silent_p.L603L|MEN1_uc001obq.2_Silent_p.L608L|MEN1_uc001obr.2_Silent_p.L608L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	608					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						GCTGCCGCTTGAGGAAAGACA	0.577			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	114	177										C	64571830	G	C	64571830	2	2	113	1	0	0	0	0	0	0	0	1	9472	1277	45	1		1	MEN1	11	64571830	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	1808544	64571830	70434686	102	34298										
GSTP1	2950	broad.mit.edu	37	chr11	67353963	67353963	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gctctcagcatatgtggggcGcctcagtgcccggcccaagc	13	15	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:67353963G>C	uc001omf.2	+	7	797	c.548G>C	c.(547-549)CGC>CCC	p.R183P	GSTP1_uc001omg.1_Missense_Mutation_p.R164P	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	183	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TATGTGGGGCGCCTCAGTGCC	0.617													0	0	0	0.00278	0	22	38										C	67353963	G	C	67353963	3	2	113	1	0	0	0	0	1	0	0	0	6844	1087	38	4	574	4	GSTP1	11	67353963	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2782133	67353963	67652553	103	34299										
PIWIL4	143689	broad.mit.edu	37	chr11	94310554	94310554	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	atattccagatttagcatctAgaaggctgagaattgcttta	8	6	1	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:94310554A>G	uc001pfa.2	+	4	620	c.409A>G	c.(409-411)AGA>GGA	p.R137G	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	137					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTTAGCATCTAGAAGGCTGAG	0.383													0	0	0	0.009096	0	4	52										G	94310554	A	G	94310554	3	3	113	1	0	0	0	0	1	0	0	0	11960	412	15	5	423	5	PIWIL4	11	94310554	Missense_Mutation	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	26956591	94310554	40695962	104	34300										
CACNA1C	775	broad.mit.edu	37	chr12	2602373	2602373	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gagatgttccagcagaagatGacccttccccttgtgcgctg	11	12	0	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:2602373G>T	uc009zdu.1	+	7	1247	c.934G>T	c.(934-936)GAC>TAC	p.D312Y	CACNA1C_uc009zdv.1_Missense_Mutation_p.D309Y|CACNA1C_uc001qkb.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkc.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qke.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkf.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qjz.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkd.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkg.2_Missense_Mutation_p.D312Y|CACNA1C_uc009zdw.1_Missense_Mutation_p.D312Y|CACNA1C_uc001qkh.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkl.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkn.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qko.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkp.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkr.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qku.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkq.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qks.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkt.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.D48Y|CACNA1C_uc001qkj.1_Missense_Mutation_p.D48Y|CACNA1C_uc001qkk.1_Missense_Mutation_p.D48Y|CACNA1C_uc001qkm.1_Missense_Mutation_p.D48Y	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	312	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGCAGAAGATGACCCTTCCCC	0.592													1	0	2.87052e-16	0.005524	3.0665e-16	39	65										T	2602373	G	T	2602373	3	4	113	1	0	0	0	0	1	0	0	0	2540	1290	45	3	960	3	CACNA1C	12	2602373	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		2602373	131249522	105	34301										
TULP3	7289	broad.mit.edu	37	chr12	3000150	3000150	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gccggctcagtcccagcggcGacaggtcagacagggccgtg	16	14	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:3000150G>C	uc010seh.1	+	1	118	c.37G>C	c.(37-39)GAC>CAC	p.D13H	TULP3_uc010sef.1_Intron|TULP3_uc009zec.1_5'UTR|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.D13H|TULP3_uc010sei.1_5'UTR	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	13					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TCCCAGCGGCGACAGGTCAGA	0.711													0	0	0	0.00308	0	7	13										C	3000150	G	C	3000150	3	2	113	1	0	0	0	0	1	0	0	0	16772	1058	37	1	39	1	TULP3	12	3000150	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	397777	3000150	130851745	106	34302										
GPRC5A	9052	broad.mit.edu	37	chr12	13062090	13062090	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agaacagagcctactctcaaGaggaaatcactcaaggtaca	8	10	3	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:13062090G>C	uc001rba.2	+	2	1557	c.907G>C	c.(907-909)GAG>CAG	p.E303Q	GPRC5A_uc001raz.2_Missense_Mutation_p.E303Q	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	303	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	CTACTCTCAAGAGGAAATCAC	0.398													0	0	0	0.003954	0	21	37										C	13062090	G	C	13062090	3	2	113	1	0	0	0	0	1	0	0	0	6724	943	33	1	909	1	GPRC5A	12	13062090	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	10061940	13062090	120789805	107	34303										
PYROXD1	79912	broad.mit.edu	37	chr12	21608984	21608984	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gataatgtaggaagtgcattGggaccagattggcatgaagg	15	4	0	2	rs137912595		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:21608984G>A	uc001rew.2	+	7	832	c.705G>A	c.(703-705)TTG>TTA	p.L235L	PYROXD1_uc009ziq.2_5'UTR|PYROXD1_uc009zir.2_5'UTR	NM_024854	NP_079130	Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase	235							oxidoreductase activity			ovary(1)	1						GAAGTGCATTGGGACCAGATT	0.308													0	0	0	0.01441	0	43	64										A	21608984	G	A	21608984	2	1	113	1	0	0	0	0	0	0	0	1	12866	1339	47	2		2	PYROXD1	12	21608984	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	8546894	21608984	112242911	108	34304										
SLC38A2	54407	broad.mit.edu	37	chr12	46757598	46757598	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tggacacattcatcattcttCtacggctgcggctatgtaat	8	10	4	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:46757598C>A	uc001rpg.2	-	12	1405	c.965G>T	c.(964-966)AGA>ATA	p.R322I	SLC38A2_uc010sli.1_Missense_Mutation_p.R160I|SLC38A2_uc001rph.2_Missense_Mutation_p.R222I	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	322	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		CATCATTCTTCTACGGCTGCG	0.338													1	0	1.33986e-20	0.004656	1.46067e-20	25	56										A	46757598	C	A	46757598	3	1	113	1	0	0	0	0	1	0	0	0	14604	913	32	3	575	3	SLC38A2	12	46757598	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	25148614	46757598	87094297	109	34305										
ASB8	140461	broad.mit.edu	37	chr12	48547243	48547243	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ggagagagagtatttgctctGaatgctctgcataatatacc	10	7	2	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:48547243G>A	uc001rrh.2	-	2	206	c.37C>T	c.(37-39)CAG>TAG	p.Q13*	ASB8_uc010slr.1_Nonsense_Mutation_p.Q9*	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	13					intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						TATTTGCTCTGAATGCTCTGC	0.448													0	0	0	0.01441	0	55	81										A	48547243	G	A	48547243	4	1	113	1	0	0	0	0	0	1	0	0	1029	1299	45	1	841	1	ASB8	12	48547243	Nonsense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	1789645	48547243	85304652	110	34306										
ZNF641	121274	broad.mit.edu	37	chr12	48736909	48736909	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gtgtgggtcagccagtgtctCacaaggtggtgccttcggcc	15	11	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:48736909C>T	uc001rrn.1	-	6	1329	c.1164G>A	c.(1162-1164)GTG>GTA	p.V388V	ZNF641_uc001rro.1_Silent_p.V374V|ZNF641_uc010sls.1_Silent_p.V365V	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	388	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						GCCAGTGTCTCACAAGGTGGT	0.597													0	0	0	0.00499	0	14	179										T	48736909	C	T	48736909	2	4	113	1	0	0	0	0	0	0	0	1	18054	813	29	1		1	ZNF641	12	48736909	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	189666	48736909	85114986	111	34307										
GPD1	2819	broad.mit.edu	37	chr12	50500080	50500080	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cctgtgctcagggggtagacGagggccccaatgggctgaag	17	10	1	2	rs34783513	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:50500080G>A	uc001rvz.2	+	4	403	c.370G>A	c.(370-372)GAG>AAG	p.E124K	GPD1_uc001rwa.2_Missense_Mutation_p.E101K	NM_005276	NP_005267	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	124					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)	GGGGGTAGACGAGGGCCCCAA	0.622													0	0	0	0.004672	0	3	31										A	50500080	G	A	50500080	3	1	113	1	0	0	0	0	1	0	0	0	6604	1059	37	1	384	1	GPD1	12	50500080	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	1763171	50500080	83351815	112	34308										
KRT2	3849	broad.mit.edu	37	chr12	53045870	53045870	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gagccgctgctgaagccccgGaatcctcctccacctcctcc	8	20	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:53045870G>A	uc001sat.2	-	1	90	c.57C>T	c.(55-57)TTC>TTT	p.F19F		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	19	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		TGAAGCCCCGGAAtcctcctc	0.498													0	0	0	0.000602	0	5	9										A	53045870	G	A	53045870	2	1	113	1	0	0	0	0	0	0	0	1	8457	1165	41	1		1	KRT2	12	53045870	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2545790	53045870	80806025	113	34309										
ERBB3	2065	broad.mit.edu	37	chr12	56487277	56487277	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgaactggaccaaggtgcttCgggggcctacggaagagcga	16	9	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:56487277C>T	uc001sjh.2	+	12	1616	c.1423C>T	c.(1423-1425)CGG>TGG	p.R475W	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.R416W|ERBB3_uc009zok.2_5'Flank|ERBB3_uc001sjk.2_5'Flank|ERBB3_uc001sjj.1_Missense_Mutation_p.R43W	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	475	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAAGGTGCTTCGGGGGCCTAC	0.547													0	0	0	0.01441	0	91	61										T	56487277	C	T	56487277	3	4	113	1	0	0	0	0	1	0	0	0	5208	875	31	1	1600	1	ERBB3	12	56487277	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	3441407	56487277	77364618	114	34310										
TMEM194A	23306	broad.mit.edu	37	chr12	57472424	57472425	+	Missense_Mutation	DNP	GG	GG	AA													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gtgccgtagaccaagcagccGgagaggatcaagagtagccg							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:57472424_57472425GG>AA	uc001smy.2	-	1	150_151	c.104_105CC>TT	c.(103-105)TCC>TTT	p.S35F	TMEM194A_uc001smx.2_Missense_Mutation_p.S35F|TMEM194A_uc010sra.1_5'UTR	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	35	Helical; (Potential).					integral to membrane					0						CCAAGCAGCCGGAGAGGATCAA	0.673													0	0	0	0.004672	0	57	181										AA	57472425	GG	AA	57472424	3	1	113	1	0	0	0	0	1	0	0	0	16113	1103	39	2	1265	2	TMEM194A	12	57472424	Missense_Mutation	DNP	GG	TCGA-GU-A42R-01A-11D-A23M-08	985147	57472424	76379471	115	34311										
WIF1	11197	broad.mit.edu	37	chr12	65445160	65445169	+	Frame_Shift_Del	DEL	CGCCGCTCCT	CGCCGCTCCT	-													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aattggattcaggtggatccCgccgctcctcggccttttta					rs145628728	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:65445160_65445169delCGCCGCTCCT	uc001ssk.2	-	10	1245_1254	c.1100_1109delAGGAGCGGCG	c.(1099-1110)GAGGAGCGGCGGfs	p.E367fs		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	367_370					multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		AGGTGGATCCCGCCGCTCCTCGGCCTTTTT	0.495			T	HMGA2	pleomorphic salivary gland adenoma													24	132	---	---								-	65445169	CGCCGCTCCT	-	65445160	7	5	113	1	0	1	0	1	0	0	0	0	17363	652	23	0	34	0	WIF1	12	65445160	Frame_Shift_Del	DEL	CGCCGCTCCT	TCGA-GU-A42R-01A-11D-A23M-08	7972736	65445160	68406735	116	34312										
LEMD3	23592	broad.mit.edu	37	chr12	65564407	65564407	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ggcggccgcggagcagggagGagggtgtgatcaagtggact	21	7	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:65564407G>T	uc001ssl.1	+	1	1037	c.1031G>T	c.(1030-1032)GGA>GTA	p.G344V	LEMD3_uc009zqo.1_Missense_Mutation_p.G344V	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	344					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GAGCAGGGAGGAGGGTGTGAT	0.627													1	0	2.32416e-17	0.014323	2.50294e-17	22	71										T	65564407	G	T	65564407	3	4	113	1	0	0	0	0	1	0	0	0	8721	1174	41	3	1033	3	LEMD3	12	65564407	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	119247	65564407	68287488	117	34313										
TRHDE	29953	broad.mit.edu	37	chr12	73012710	73012710	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aatattcctctggagattatCagatacctgtctgaggagaa	9	7	3	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:73012710C>T	uc001sxa.2	+	13	2256	c.2226C>T	c.(2224-2226)ATC>ATT	p.I742I		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	742	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TGGAGATTATCAGATACCTGT	0.398													0	0	0	0.007291	0	29	62										T	73012710	C	T	73012710	2	4	113	1	0	0	0	0	0	0	0	1	16476	816	29	1		1	TRHDE	12	73012710	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	7448303	73012710	60839185	118	34314										
KRR1	11103	broad.mit.edu	37	chr12	75905329	75905329	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cggcttctggttacgaaattCactttttccagcgccttttt	7	11	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:75905329C>T	uc001sxt.2	-	1	90	c.49G>A	c.(49-51)GAA>AAA	p.E17K	KRR1_uc009zsc.2_Missense_Mutation_p.E17K|KRR1_uc010stx.1_Missense_Mutation_p.E17K	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	17					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						TTACGAAATTCACTTTTTCCA	0.502													0	0	0	0.01441	0	46	100										T	75905329	C	T	75905329	3	4	113	1	0	0	0	0	1	0	0	0	8446	835	29	1	1136	1	KRR1	12	75905329	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	2892619	75905329	57946566	119	34315										
SLC17A8	246213	broad.mit.edu	37	chr12	100797869	100797869	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	atgacaatcgttgtacctatTggaggacaattggctgatta	10	6	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:100797869T>C	uc010svi.1	+	9	1420	c.1107T>C	c.(1105-1107)ATT>ATC	p.I369I	SLC17A8_uc009ztx.2_Silent_p.I319I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	369	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TTGTACCTATTGGAGGACAAT	0.403													0	0	0	0.012213	0	31	67										C	100797869	T	C	100797869	2	2	113	1	0	0	0	0	0	0	0	1	14423	1800	63	5		5	SLC17A8	12	100797869	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	24892540	100797869	33054026	120	34316										
MED13L	23389	broad.mit.edu	37	chr12	116403955	116403955	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aaaccactggggaagattctCagctttggcagttgatacaa	10	8	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:116403955C>G	uc001tvw.2	-	29	6374	c.6319G>C	c.(6319-6321)GAG>CAG	p.E2107Q		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	2107					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGAAGATTCTCAGCTTTGGCA	0.488													0	0	0	0.01441	0	75	135										G	116403955	C	G	116403955	3	3	113	1	0	0	0	0	1	0	0	0	9431	835	29	1	325	1	MED13L	12	116403955	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	15606086	116403955	17447940	121	34317										
BRCA2	675	broad.mit.edu	37	chr13	32912514	32912514	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agaatttgatggcagtgattCaagtaaaaatgatactgttt	9	3	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:32912514C>G	uc001uub.1	+	11	4249	c.4022C>G	c.(4021-4023)TCA>TGA	p.S1341*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1341					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGCAGTGATTCAAGTAAAAAT	0.303			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00333	0	25	46										G	32912514	C	G	32912514	4	3	113	1	0	0	0	0	0	1	0	0	1499	838	29	1	4060	1	BRCA2	13	32912514	Nonsense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		32912514	82257364	122	34318										
CAB39L	81617	broad.mit.edu	37	chr13	49933858	49933858	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccatgtacctaccctttgagGagcataaacaggatatgagg	10	9	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:49933858G>A	uc001vcw.2	-	4	885	c.387C>T	c.(385-387)CTC>CTT	p.L129L	CAB39L_uc001vcx.2_Silent_p.L129L|CAB39L_uc010adf.2_Silent_p.L126L	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	129					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		ACCCTTTGAGGAGCATAAACA	0.393													0	0	0	0.013726	0	30	79										A	49933858	G	A	49933858	2	1	113	1	0	0	0	0	0	0	0	1	2526	1161	41	1		1	CAB39L	13	49933858	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	17021344	49933858	65236020	123	34319										
KLHL1	57626	broad.mit.edu	37	chr13	70681661	70681661	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccgcttctctcttggcttttGagcaggcgactctggctggg	13	12	3	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:70681661G>C	uc001vip.2	-	1	965	c.171C>G	c.(169-171)CTC>CTG	p.L57L	KLHL1_uc010thm.1_Silent_p.L57L|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	57	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTTGGCTTTTGAGCAGGCGAC	0.473													0	0	0	0.01441	0	49	92										C	70681661	G	C	70681661	2	2	113	1	0	0	0	0	0	0	0	1	8365	1277	45	1		1	KLHL1	13	70681661	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	20747803	70681661	44488217	124	34320										
DACH1	1602	broad.mit.edu	37	chr13	72146982	72146982	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aaagaattaccttaataactGatgtctcaactctggatggg	8	7	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:72146982G>C	uc010thn.1	-	5	1712	c.1289C>G	c.(1288-1290)TCA>TGA	p.S430*	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	482					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CTTAATAACTGATGTCTCAAC	0.398													0	0	0	0.010771	0	42	83										C	72146982	G	C	72146982	4	2	113	1	0	0	0	0	0	1	0	0	4220	1294	45	1	863	1	DACH1	13	72146982	Nonsense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	1465321	72146982	43022896	125	34321										
SLITRK5	26050	broad.mit.edu	37	chr13	88329086	88329086	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gagttattctatggcctgcaGagcctgcagtatctcttcct	9	11	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:88329086G>A	uc001vln.2	+	2	1662	c.1443G>A	c.(1441-1443)CAG>CAA	p.Q481Q	SLITRK5_uc010tic.1_Silent_p.Q240Q	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	481	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATGGCCTGCAGAGCCTGCAGT	0.537													0	0	0	0.01441	0	49	70										A	88329086	G	A	88329086	2	1	113	1	0	0	0	0	0	0	0	1	14746	933	33	1		1	SLITRK5	13	88329086	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	16182104	88329086	26840792	126	34322										
GPC5	2262	broad.mit.edu	37	chr13	92797155	92797155	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gcagtggtggaggcatggttGaacaagtcagtggggactgt	18	5	1	1	rs143874024		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:92797155G>A	uc010tif.1	+	7	1840	c.1474G>A	c.(1474-1476)GAA>AAA	p.E492K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	492						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGGCATGGTTGAACAAGTCAG	0.468													0	0	0	0.01441	0	48	91										A	92797155	G	A	92797155	3	1	113	1	0	0	0	0	1	0	0	0	6601	1291	45	1	1500	1	GPC5	13	92797155	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	4468069	92797155	22372723	127	34323										
FAM70B	348013	broad.mit.edu	37	chr13	114498181	114498181	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccgccttctgctgcgccatcGtggacggcgtatttgcagca	12	14	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:114498181G>A	uc001vuh.2	+	4	340	c.313G>A	c.(313-315)GTG>ATG	p.V105M		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	105	Helical; (Potential).					integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			CTGCGCCATCGTGGACGGCGT	0.527													0	0	0	0.01441	0	52	57										A	114498181	G	A	114498181	3	1	113	1	0	0	0	0	1	0	0	0	5606	1145	40	2	327	2	FAM70B	13	114498181	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	21701026	114498181	671697	128	34324										
MIA2	117153	broad.mit.edu	37	chr14	39717074	39717074	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gaaatagaaacgataaaaatTatagaaacagaagatcaaat	6	3	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:39717074T>C	uc001wux.2	+	4	1490	c.1296T>C	c.(1294-1296)ATT>ATC	p.I432I	MIA2_uc010amy.1_Silent_p.I363I	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	432						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		CGATAAAAATTATAGAAACAG	0.318													0	0	0	0.01441	0	54	74										C	39717074	T	C	39717074	2	2	113	1	0	0	0	0	0	0	0	1	9564	1742	61	5		5	MIA2	14	39717074	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08		39717074	67632466	129	34325										
ARID4A	5926	broad.mit.edu	37	chr14	58831658	58831658	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aagatgaggatgcaatgcctCtgatcgggcctgaaaccttg	12	9	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:58831658C>G	uc001xdp.2	+	20	3105	c.2851C>G	c.(2851-2853)CTG>GTG	p.L951V	ARID4A_uc001xdo.2_Missense_Mutation_p.L951V|ARID4A_uc001xdq.2_Missense_Mutation_p.L951V|ARID4A_uc010apg.1_Missense_Mutation_p.L629V	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	951	Retinoblastoma protein binding (Potential).				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TGCAATGCCTCTGATCGGGCC	0.408													0	0	0	0.01441	0	57	125										G	58831658	C	G	58831658	3	3	113	1	0	0	0	0	1	0	0	0	919	912	32	1	2925	1	ARID4A	14	58831658	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	19114584	58831658	48517882	130	34326										
SNAPC1	6617	broad.mit.edu	37	chr14	62244847	62244847	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aaaaaatggaaggaaattcaCaagaaacggaggtcagaaaa	10	4	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:62244847C>G	uc001xft.2	+	6	855	c.751C>G	c.(751-753)CAA>GAA	p.Q251E		NM_003082	NP_003073	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex,	251	SNAPC4-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		AGGAAATTCACAAGAAACGGA	0.294													0	0	0	0.010504	0	18	48										G	62244847	C	G	62244847	3	3	113	1	0	0	0	0	1	0	0	0	14834	479	17	4	773	4	SNAPC1	14	62244847	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	3413189	62244847	45104693	131	34327										
VTI1B	10490	broad.mit.edu	37	chr14	68123177	68123177	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gtctcgttgttcccccagctCttctatgatttctgagccaa	7	13	4	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:68123177C>T	uc001xjt.2	-	4	892	c.496G>A	c.(496-498)GAG>AAG	p.E166K	VTI1B_uc010aqp.2_Missense_Mutation_p.E105K|VTI1B_uc001xju.2_Missense_Mutation_p.E125K	NM_006370	NP_006361	Q9UEU0	VTI1B_HUMAN	vesicle transport through interaction with	166	Potential.|Cytoplasmic (Potential).				cell proliferation|cellular membrane fusion|intracellular protein transport|vesicle docking involved in exocytosis	endomembrane system|integral to membrane					0				all cancers(60;0.000344)|OV - Ovarian serous cystadenocarcinoma(108;0.00212)|BRCA - Breast invasive adenocarcinoma(234;0.00941)		TCCCCCAGCTCTTCTATGATT	0.522													0	0	0	0.01441	0	86	168										T	68123177	C	T	68123177	3	4	113	1	0	0	0	0	1	0	0	0	17233	922	32	1	214	1	VTI1B	14	68123177	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	5878330	68123177	39226363	132	34328										
CATSPERB	79820	broad.mit.edu	37	chr14	92074642	92074642	+	Missense_Mutation	SNP	G	G	A													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	taaaaaagttatttacctttGacatgtgaaacatgtttctt							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:92074642G>A	uc001xzs.1	-	22	2845	c.2705C>T	c.(2704-2706)TCA>TTA	p.S902L	CATSPERB_uc010aub.1_Missense_Mutation_p.S424L	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	902					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ATTTACCTTTGACATGTGAAA	0.308													0	0	0	0.009535	0	27	51										A	92074642	G	A	92074642	3	1	113	1	0	0	0	0	1	0	0	0	2691	1294	45	1	669	1	CATSPERB	14	92074642	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	23951465	92074642	15274898	133	34329	176	2								
CATSPERB	79820	broad.mit.edu	37	chr14	92074649	92074649	+	Missense_Mutation	SNP	G	G	A													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gttatttacctttgacatgtGaaacatgtttcttggtatgg							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:92074649G>A	uc001xzs.1	-	22	2838	c.2698C>T	c.(2698-2700)CAC>TAC	p.H900Y	CATSPERB_uc010aub.1_Missense_Mutation_p.H422Y	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	900					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TTTGACATGTGAAACATGTTT	0.299													0	0	0	0.013726	0	29	54										A	92074649	G	A	92074649	3	1	113	1	0	0	0	0	1	0	0	0	2691	1290	45	1	676	1	CATSPERB	14	92074649	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	7	92074649	15274891	134	34330	176	2								
KIAA1409	57578	broad.mit.edu	37	chr14	94155051	94155051	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccagcctctgcatgaagataCctttgggggacatctcaaag	10	11	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:94155051C>A	uc001ybv.1	+	43	6685	c.6602C>A	c.(6601-6603)ACC>AAC	p.T2201N	KIAA1409_uc001ybs.1_Missense_Mutation_p.T2179N	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2356						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CATGAAGATACCTTTGGGGGA	0.502													1	0	1.60099e-16	0.004878	1.71719e-16	38	69										A	94155051	C	A	94155051	3	1	113	1	0	0	0	0	1	0	0	0	8230	507	18	4	6702	4	KIAA1409	14	94155051	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	2080402	94155051	13194489	135	34331										
PPP4R4	57718	broad.mit.edu	37	chr14	94711948	94711948	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tagatgctcttatagatcatCttccagaaatcttggaactt	6	8	4	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:94711948C>T	uc001ycs.1	+	13	1523	c.1369C>T	c.(1369-1371)CTT>TTT	p.L457F		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	457						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TATAGATCATCTTCCAGAAAT	0.308													0	0	0	0.01441	0	66	90										T	94711948	C	T	94711948	3	4	113	1	0	0	0	0	1	0	0	0	12405	913	32	1	1492	1	PPP4R4	14	94711948	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	556897	94711948	12637592	136	34332										
OCA2	4948	broad.mit.edu	37	chr15	28231760	28231760	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gcacaataatcgaaaaatccCgtttctgaaaatatggctac	6	9	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:28231760C>T	uc001zbh.3	-	12	1322	c.1212G>A	c.(1210-1212)ACG>ACA	p.T404T	OCA2_uc010ayv.2_Silent_p.T380T	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	404	Cytoplasmic (Potential).		T -> M (in OCA2).		eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CGAAAAATCCCGTTTCTGAAA	0.303									Oculocutaneous_Albinism				0	0	0	0.01441	0	67	132										T	28231760	C	T	28231760	2	4	113	1	0	0	0	0	0	0	0	1	10815	639	23	2		2	OCA2	15	28231760	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		28231760	74299632	137	34333										
MTMR15	22909	broad.mit.edu	37	chr15	31197051	31197051	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttaaaccggcaccttgatgAaatgtgtgctaacaatgact	8	9	0	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:31197051A>G	uc001zff.2	+	2	476	c.185A>G	c.(184-186)GAA>GGA	p.E62G	MTMR15_uc001zfc.3_Missense_Mutation_p.E62G|MTMR15_uc010azw.2_Missense_Mutation_p.E62G|MTMR15_uc001zfd.3_Missense_Mutation_p.E62G|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	62	UBZ-type.				double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		CACCTTGATGAAATGTGTGCT	0.403								Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.00499	0	17	60										G	31197051	A	G	31197051	3	3	113	1	0	0	0	0	1	0	0	0	9943	246	9	5	187	5	MTMR15	15	31197051	Missense_Mutation	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	2965291	31197051	71334341	138	34334										
RYR3	6263	broad.mit.edu	37	chr15	33795931	33795931	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccaacacaggtgaaaatggcGgcgaaggggtgagtacccga	15	9	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:33795931G>A	uc001zhi.2	+	3	341	c.271G>A	c.(271-273)GGC>AGC	p.G91S	RYR3_uc010bar.2_Missense_Mutation_p.G91S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	91	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGAAAATGGCGGCGAAGGGGT	0.483													0	0	0	0.001168	0	4	15										A	33795931	G	A	33795931	3	1	113	1	0	0	0	0	1	0	0	0	13770	1116	39	2	281	2	RYR3	15	33795931	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2598880	33795931	68735461	139	34335										
BUB1B	701	broad.mit.edu	37	chr15	40488917	40488917	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tatgcaggagtaggggaattCtcctttgaagaaattcgggc	13	6	1	2	rs61733369	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:40488917C>G	uc001zkx.3	+	9	1442	c.1230C>G	c.(1228-1230)TTC>TTG	p.F410L	BUB1B_uc010ucl.1_Missense_Mutation_p.F273L	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	410					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TAGGGGAATTCTCCTTTGAAG	0.408			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.01441	0	51	94										G	40488917	C	G	40488917	3	3	113	1	0	0	0	0	1	0	0	0	1571	912	32	1	1264	1	BUB1B	15	40488917	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	6692986	40488917	62042475	140	34336										
SLC27A2	11001	broad.mit.edu	37	chr15	50519375	50519375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cagagttggagatacattccGgttggtttttctgaatcatt	10	6	2	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:50519375G>A	uc001zxw.2	+	7	1689	c.1457G>A	c.(1456-1458)CGG>CAG	p.R486Q	SLC27A2_uc010bes.2_Missense_Mutation_p.R433Q|SLC27A2_uc001zxx.2_Missense_Mutation_p.R251Q	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	486	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GATACATTCCGGTTGGTTTTT	0.403													0	0	0	0.010818	0	30	58										A	50519375	G	A	50519375	3	1	113	1	0	0	0	0	1	0	0	0	14526	1130	39	2	1483	2	SLC27A2	15	50519375	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	10030458	50519375	52012017	141	34337										
CPLX3	594855	broad.mit.edu	37	chr15	75122674	75122674	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ggggatctcaagcaatcagcTgagaagtgtcacgtcatgtg	13	8	4	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:75122674T>C	uc002ayu.1	+	3	550	c.456T>C	c.(454-456)GCT>GCC	p.A152A		NM_001030005	NP_001025176	Q8WVH0	CPLX3_HUMAN	complexin 3 precursor	152						cell junction|synapse	syntaxin binding				0						AGCAATCAGCTGAGAAGTGTC	0.602													0	0	0	0.00245	0	14	29										C	75122674	T	C	75122674	2	2	113	1	0	0	0	0	0	0	0	1	3806	1567	55	5		5	CPLX3	15	75122674	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	24603299	75122674	27408718	142	34338										
RLBP1	6017	broad.mit.edu	37	chr15	89760379	89760379	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agctcataggcacggcccacGttgaacttccgtgcgcggat	12	13	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:89760379G>A	uc002bnl.2	-	5	698	c.318C>T	c.(316-318)AAC>AAT	p.N106N		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	106					response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	CACGGCCCACGTTGAACTTCC	0.657													0	0	0	0.008871	0	18	41										A	89760379	G	A	89760379	2	1	113	1	0	0	0	0	0	0	0	1	13388	1136	40	2		2	RLBP1	15	89760379	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	14637705	89760379	12771013	143	34339										
SETD1A	9739	broad.mit.edu	37	chr16	30995215	30995215	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	accatcgagtcccagaagaaGatcgtgatctactccaagca	8	12	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr16:30995215G>A	uc002ead.1	+	19	5681	c.4995G>A	c.(4993-4995)AAG>AAA	p.K1665K	HSD3B7_uc002eaf.2_5'Flank|HSD3B7_uc010cac.2_5'Flank|HSD3B7_uc002eag.2_5'Flank|HSD3B7_uc002eah.2_5'Flank	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1665	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCCAGAAGAAGATCGTGATCT	0.582													0	0	0	0.010729	0	11	14										A	30995215	G	A	30995215	2	1	113	1	0	0	0	0	0	0	0	1	14130	933	33	1		1	SETD1A	16	30995215	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		30995215	59359538	144	34340										
ABCC12	94160	broad.mit.edu	37	chr16	48138177	48138177	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctgcagaaagttctctgcgtGaaacggcagcctcacatcca	9	13	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr16:48138177G>A	uc002efc.1	-	20	3122	c.2776C>T	c.(2776-2778)CAC>TAC	p.H926Y	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	926	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TTCTCTGCGTGAAACGGCAGC	0.488													0	0	0	0.01441	0	83	160										A	48138177	G	A	48138177	3	1	113	1	0	0	0	0	1	0	0	0	52	1290	45	1	1343	1	ABCC12	16	48138177	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	17142962	48138177	42216576	145	34341										
CA5A	763	broad.mit.edu	37	chr16	87921738	87921738	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	atgtggacctaatgtctctaGgaccttgtgccctcattagt	9	10	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr16:87921738G>A	uc002fkn.1	-	7	971	c.915C>T	c.(913-915)TCC>TCT	p.S305S		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	305					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		AATGTCTCTAGGACCTTGTGC	0.458													0	0	0	0.01441	0	41	66										A	87921738	G	A	87921738	2	1	113	1	0	0	0	0	0	0	0	1	2519	987	35	2		2	CA5A	16	87921738	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	39783561	87921738	2433015	146	34342										
TRPV3	162514	broad.mit.edu	37	chr17	3432259	3432259	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	catatgcagcagcgtgtgcaGcggctccagggtcagcatct	13	12	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:3432259G>A	uc002fvt.1	-	10	1595	c.1273C>T	c.(1273-1275)CTG>TTG	p.L425L	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Silent_p.L409L|TRPV3_uc010vri.1_Silent_p.L380L|TRPV3_uc010vrj.1_Silent_p.L409L|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Silent_p.L409L|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Silent_p.L425L|TRPV3_uc002fvu.2_Silent_p.L425L|TRPV3_uc010vrn.1_Silent_p.L7L	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	425	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	AGCGTGTGCAGCGGCTCCAGG	0.517													0	0	0	0.01441	0	111	164										A	3432259	G	A	3432259	2	1	113	1	0	0	0	0	0	0	0	1	16594	962	34	2		2	TRPV3	17	3432259	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		3432259	77762951	147	34343										
WDR16	146845	broad.mit.edu	37	chr17	9545099	9545099	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agaattggaaggttccctgtCtgggtcgataaatggcatgg	14	6	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:9545099C>T	uc002gly.2	+	13	1703	c.1634C>T	c.(1633-1635)TCT>TTT	p.S545F	WDR16_uc002glz.2_Missense_Mutation_p.S477F|WDR16_uc010coc.2_Missense_Mutation_p.S555F	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	545	WD 10.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GGTTCCCTGTCTGGGTCGATA	0.463													0	0	0	0.013114	0	38	25										T	9545099	C	T	9545099	3	4	113	1	0	0	0	0	1	0	0	0	17273	913	32	1	1684	1	WDR16	17	9545099	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	6112840	9545099	71650111	148	34344										
MYH13	8735	broad.mit.edu	37	chr17	10231294	10231294	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agttcttccttggtcctctcAaagtcttccttcatggtggc	8	12	4	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:10231294A>G	uc002gmk.1	-	22	2670	c.2580T>C	c.(2578-2580)TTT>TTC	p.F860F		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	860	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGTCCTCTCAAAGTCTTCCT	0.547											OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00623	0	37	20										G	10231294	A	G	10231294	2	3	113	1	0	0	0	0	0	0	0	1	10032	127	5	5		5	MYH13	17	10231294	Silent	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	686195	10231294	70963916	149	34345										
LRRC37B	114659	broad.mit.edu	37	chr17	30358451	30358451	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttggaacatttcaggcctgGcacggaatgcagtttttaca	10	9	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:30358451G>C	uc002hgu.2	+	5	1961	c.1950G>C	c.(1948-1950)TGG>TGC	p.W650C	LRRC37B_uc010wbx.1_Missense_Mutation_p.W568C|LRRC37B_uc010csu.2_Intron	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	650	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TTCAGGCCTGGCACGGAATGC	0.328													0	0	0	0.00333	0	16	145										C	30358451	G	C	30358451	3	2	113	1	0	0	0	0	1	0	0	0	8994	1212	42	4	1968	4	LRRC37B	17	30358451	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	20127157	30358451	50836759	150	34346										
ZNF830	91603	broad.mit.edu	37	chr17	33289624	33289624	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aactgcagaaaaaggaagaaGagaatgctgacagcgatgat	12	5	0	5			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:33289624G>C	uc002hih.3	+	1	1076	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	CCT6B_uc002hig.2_5'Flank|CCT6B_uc010ctg.2_5'Flank|CCT6B_uc010wcc.1_5'Flank	NM_052857	NP_443089	Q96NB3	ZN830_HUMAN	coiled-coil domain containing 16	347	Potential.				cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)	1		Ovarian(249;0.17)				AAAGGAAGAAGAGAATGCTGA	0.423													0	0	0	0.01441	0	104	68										C	33289624	G	C	33289624	3	2	113	1	0	0	0	0	1	0	0	0	18181	943	33	1	1041	1	ZNF830	17	33289624	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2931173	33289624	47905586	151	34347										
MMP28	79148	broad.mit.edu	37	chr17	34094869	34094869	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cctgcagtggacggggctctGagacgttgccatcagctgcc	14	13	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:34094869G>C	uc002hjy.1	-	9	1329	c.1070C>G	c.(1069-1071)TCA>TGA	p.S357*	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	357	Hemopexin-like 1.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACGGGGCTCTGAGACGTTGCC	0.527													0	0	0	0.007413	0	15	26										C	34094869	G	C	34094869	4	2	113	1	0	0	0	0	0	1	0	0	9665	1294	45	1	500	1	MMP28	17	34094869	Nonsense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	805245	34094869	47100341	152	34348										
CDK12	51755	broad.mit.edu	37	chr17	37687065	37687065	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccacatgagcaccaggccttGagaccaatggagtactccac	9	14	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:37687065G>C	uc010cvv.2	+	14	4555	c.3969G>C	c.(3967-3969)TTG>TTC	p.L1323F	CDK12_uc002hrw.3_Missense_Mutation_p.L1314F	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1323					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						ACCAGGCCTTGAGACCAATGG	0.562										TCGA Ovarian(9;0.13)			0	0	0	0.01441	0	101	96										C	37687065	G	C	37687065	3	2	113	1	0	0	0	0	1	0	0	0	3128	1281	45	1	4023	1	CDK12	17	37687065	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	3592196	37687065	43508145	153	34349										
MED24	9862	broad.mit.edu	37	chr17	38209839	38209839	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	caaaatggcttgcttcaggtTgaccaccttcattatttcac	6	11	3	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:38209839T>C	uc002htt.2	-	2	326	c.13A>G	c.(13-15)AAC>GAC	p.N5D	MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.N30D|MED24_uc002htu.2_Missense_Mutation_p.N5D|MED24_uc010cwn.2_Missense_Mutation_p.N5D|MED24_uc010weu.1_5'UTR|MED24_uc010wev.1_Intron|MED24_uc010wew.1_Intron|MED24_uc010wex.1_5'Flank|MED24_uc010wfa.1_5'Flank|MED24_uc010wfb.1_Missense_Mutation_p.N30D|MED24_uc010wfc.1_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	5					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TGCTTCAGGTTGACCACCTTC	0.488													0	0	0	0.01441	0	68	184										C	38209839	T	C	38209839	3	2	113	1	0	0	0	0	1	0	0	0	9442	1812	63	5	3056	5	MED24	17	38209839	Missense_Mutation	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	522774	38209839	42985371	154	34350										
KRT15	3866	broad.mit.edu	37	chr17	39674601	39674601	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccttgtcccggagctcttcaAtggtcttgaagtattggctg	11	10	3	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:39674601A>G	uc002hwy.2	-	1	670	c.479T>C	c.(478-480)ATT>ACT	p.I160T	KRT15_uc002hwz.2_Silent_p.L23L|KRT15_uc002hxa.2_Silent_p.L23L|KRT15_uc002hxb.1_Silent_p.L23L	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	160	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				GAGCTCTTCAATGGTCTTGAA	0.537													0	0	0	0.01441	0	82	81										G	39674601	A	G	39674601	3	3	113	1	0	0	0	0	1	0	0	0	8452	101	4	5	923	5	KRT15	17	39674601	Missense_Mutation	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	1464762	39674601	41520609	155	34351										
STAT5B	6777	broad.mit.edu	37	chr17	40379652	40379652	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcctgcaccaggccctccagGagctgggtggccttaatgtt	12	13	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:40379652G>C	uc002hzh.2	-	3	349	c.180C>G	c.(178-180)CTC>CTG	p.L60L	STAT5B_uc002hzi.3_Silent_p.L60L	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	60					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GGCCCTCCAGGAGCTGGGTGG	0.502													0	0	0	0.01441	0	47	35										C	40379652	G	C	40379652	2	2	113	1	0	0	0	0	0	0	0	1	15268	1161	41	1		1	STAT5B	17	40379652	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	705051	40379652	40815558	156	34352										
SCN4A	6329	broad.mit.edu	37	chr17	62029011	62029011	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cggctccttcttctcatcctCgggggcagtctcccccgcct	9	19	3	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:62029011C>T	uc002jds.1	-	14	2703	c.2626G>A	c.(2626-2628)GAG>AAG	p.E876K		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	876					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TTCTCATCCTCGGGGGCAGTC	0.657													0	0	0	0.009096	0	4	13										T	62029011	C	T	62029011	3	4	113	1	0	0	0	0	1	0	0	0	13920	893	31	1	2928	1	SCN4A	17	62029011	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	21649359	62029011	19166199	157	34353										
TIMP2	7077	broad.mit.edu	37	chr17	76866987	76866987	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cactcatacacacctgcaatGagatattccttctttcctcc	3	15	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:76866987G>A	uc002jwf.2	-	3	635	c.333C>T	c.(331-333)CTC>CTT	p.L111L	TIMP2_uc002jwe.2_Silent_p.L34L|TIMP2_uc010wty.1_Silent_p.L34L	NM_003255	NP_003246	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2 precursor	111	NTR.						metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			CACCTGCAATGAGATATTCCT	0.582													0	0	0	0.01441	0	90	103										A	76866987	G	A	76866987	2	1	113	1	0	0	0	0	0	0	0	1	15915	1277	45	1		1	TIMP2	17	76866987	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	14837976	76866987	4328223	158	34354										
PYCR1	5831	broad.mit.edu	37	chr17	79891201	79891201	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	accttgtccaggatggtcttCttgatggcggctggtgacac	13	10	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:79891201C>T	uc002kcr.1	-	7	1127	c.849G>A	c.(847-849)AAG>AAA	p.K283K	PYCR1_uc002kcq.1_3'UTR|PYCR1_uc002kcp.2_Silent_p.K283K|PYCR1_uc002kcs.1_3'UTR|PYCR1_uc010wvd.1_Silent_p.K310K|PYCR1_uc002kct.1_Silent_p.K283K|PYCR1_uc002kcu.1_Silent_p.K252K	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	283					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	GGATGGTCTTCTTGATGGCGG	0.642													0	0	0	0.00333	0	22	54										T	79891201	C	T	79891201	2	4	113	1	0	0	0	0	0	0	0	1	12855	912	32	1		1	PYCR1	17	79891201	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	3024214	79891201	1304009	159	34355										
PIK3C3	5289	broad.mit.edu	37	chr18	39584344	39584344	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgacaaaattcttgaaatgtGttaattgggatctacctcaa	7	6	3	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr18:39584344G>A	uc002lap.2	+	10	1067	c.1009G>A	c.(1009-1011)GTT>ATT	p.V337I	PIK3C3_uc010xcl.1_Missense_Mutation_p.V274I	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	337				FLKCVN -> ILTSVI (in Ref. 1; CAA87094).	cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CTTGAAATGTGTTAATTGGGA	0.413										TSP Lung(28;0.18)			0	0	0	0.01441	0	44	15										A	39584344	G	A	39584344	3	1	113	1	0	0	0	0	1	0	0	0	11912	1377	48	2	1047	2	PIK3C3	18	39584344	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08		39584344	38492904	160	34356										
PRKCSH	5589	broad.mit.edu	37	chr19	11559788	11559788	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gaaacccaaactcgggggctCtcccaccagccttgggtgag	12	14	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:11559788C>T	uc002mrt.2	+	15	1661	c.1325C>T	c.(1324-1326)TCT>TTT	p.S442F	PRKCSH_uc002mru.2_Missense_Mutation_p.S439F|PRKCSH_uc010xlz.1_Missense_Mutation_p.S449F|PRKCSH_uc010dya.2_Missense_Mutation_p.S224F|PRKCSH_uc010dyb.2_Missense_Mutation_p.S439F	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	442	PRKCSH.				innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						CTCGGGGGCTCTCCCACCAGC	0.642													0	0	0	0.01441	0	77	145										T	11559788	C	T	11559788	3	4	113	1	0	0	0	0	1	0	0	0	12516	913	32	1	1400	1	PRKCSH	19	11559788	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		11559788	47569195	161	34357										
CYP4F11	57834	broad.mit.edu	37	chr19	16045054	16045054	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccccaaaaccagttctgtttCgggggttgaggaaaacactg	11	10	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:16045054C>T	uc002nbu.2	-	2	201	c.165G>A	c.(163-165)CCG>CCA	p.P55P	CYP4F11_uc010eab.1_Silent_p.P55P|CYP4F11_uc002nbt.2_Silent_p.P55P	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	55					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						AGTTCTGTTTCGGGGGTTGAG	0.612													0	0	0	0.006999	0	34	70										T	16045054	C	T	16045054	2	4	113	1	0	0	0	0	0	0	0	1	4186	871	31	1		1	CYP4F11	19	16045054	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	4485266	16045054	43083929	162	34358										
SIN3B	23309	broad.mit.edu	37	chr19	16982110	16982110	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agcctgctggagggcagcatCgaccccacgcagtacgagga	14	13	0	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:16982110C>T	uc002ney.1	+	15	2603	c.2589C>T	c.(2587-2589)ATC>ATT	p.I863I	SIN3B_uc002nez.1_Silent_p.I831I|SIN3B_uc010xpi.1_Silent_p.I421I	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	863					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						AGGGCAGCATCGACCCCACGC	0.612													0	0	0	0.01441	0	48	65										T	16982110	C	T	16982110	2	4	113	1	0	0	0	0	0	0	0	1	14326	874	31	1		1	SIN3B	19	16982110	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	937056	16982110	42146873	163	34359										
RFXANK	8625	broad.mit.edu	37	chr19	19308943	19308943	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	acccccacatcctggcaaaaGagcgagagagcgccctgtcg	11	15	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:19308943G>C	uc002nls.2	+	7	971	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	RFXANK_uc002nlt.2_Missense_Mutation_p.E133Q|RFXANK_uc002nlu.2_Missense_Mutation_p.E134Q|RFXANK_uc002nlv.2_Missense_Mutation_p.E156Q|RFXANK_uc002nlw.2_Missense_Mutation_p.E155Q	NM_003721	NP_003712	O14593	RFXK_HUMAN	regulatory factor X-associated	156	ANK 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2			Epithelial(12;0.00228)			CCTGGCAAAAGAGCGAGAGAG	0.597													0	0	0	0.01441	0	74	165										C	19308943	G	C	19308943	3	2	113	1	0	0	0	0	1	0	0	0	13269	943	33	1	484	1	RFXANK	19	19308943	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2326833	19308943	39820040	164	34360										
NR2C2AP	126382	broad.mit.edu	37	chr19	19313302	19313302	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccaggcagccccggcgactgGagaagccaccctgaaactgg	13	15	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:19313302G>C	uc002nlx.2	-	3	581	c.212C>G	c.(211-213)TCC>TGC	p.S71C	NR2C2AP_uc010xqq.1_5'Flank|NR2C2AP_uc002nly.2_Missense_Mutation_p.S71C	NM_176880	NP_795361	Q86WQ0	NR2CA_HUMAN	TR4 orphan receptor associated protein TRA16	71					cell adhesion|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm				ovary(1)	1			Epithelial(12;0.00235)			CCGGCGACTGGAGAAGCCACC	0.617													0	0	0	0.00278	0	22	68										C	19313302	G	C	19313302	3	2	113	1	0	0	0	0	1	0	0	0	10624	1174	41	1	219	1	NR2C2AP	19	19313302	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	4359	19313302	39815681	165	34361										
ZNF14	7561	broad.mit.edu	37	chr19	19822176	19822176	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tattcttagactttctctccCatatgagtcctttcatgcag	5	11	3	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:19822176C>T	uc002nnk.1	-	4	2068	c.1914G>A	c.(1912-1914)ATG>ATA	p.M638I		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				CTTTCTCTCCCATATGAGTCC	0.413													0	0	0	0.003271	0	32	69										T	19822176	C	T	19822176	3	4	113	1	0	0	0	0	1	0	0	0	17725	594	21	2	18	2	ZNF14	19	19822176	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	508874	19822176	39306807	166	34362										
GPI	2821	broad.mit.edu	37	chr19	34884827	34884827	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctcctgtttcaggaccagcaCttccgcacgacgcccctgga	9	17	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:34884827C>G	uc002nvg.1	+	12	1021	c.918C>G	c.(916-918)CAC>CAG	p.H306Q	GPI_uc002nvf.2_Missense_Mutation_p.H345Q|GPI_uc010xrv.1_Missense_Mutation_p.H317Q|GPI_uc010xrw.1_Missense_Mutation_p.H278Q|GPI_uc010edl.1_Missense_Mutation_p.H306Q|GPI_uc002nvi.1_5'UTR	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	306					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					AGGACCAGCACTTCCGCACGA	0.627													0	0	0	0.01441	0	106	454										G	34884827	C	G	34884827	3	3	113	1	0	0	0	0	1	0	0	0	6611	564	20	4	1085	4	GPI	19	34884827	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	15062651	34884827	24244156	167	34363										
UBA2	10054	broad.mit.edu	37	chr19	34949727	34949727	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aagcttcttgtgccttgtgcActggatcctcccaaccccaa	7	15	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:34949727A>G	uc002nvk.2	+	13	1369	c.1299A>G	c.(1297-1299)GCA>GCG	p.A433A	UBA2_uc010xrx.1_Silent_p.A306A|UBA2_uc002nvl.2_Silent_p.A337A	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	433					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TGCCTTGTGCACTGGATCCTC	0.433													0	0	0	0.01441	0	164	106										G	34949727	A	G	34949727	2	3	113	1	0	0	0	0	0	0	0	1	16825	146	6	5		5	UBA2	19	34949727	Silent	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	64900	34949727	24179256	168	34364										
ZNF546	339327	broad.mit.edu	37	chr19	40521413	40521413	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	attttagacttcatactggtGagaaaccttatagctgtaaa	7	6	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:40521413G>A	uc002oms.2	+	7	2492	c.2236G>A	c.(2236-2238)GAG>AAG	p.E746K	ZNF546_uc002omt.2_Missense_Mutation_p.E720K	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	746					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCATACTGGTGAGAAACCTTA	0.398													0	0	0	0.01441	0	150	79										A	40521413	G	A	40521413	3	1	113	1	0	0	0	0	1	0	0	0	17975	1291	45	1	2254	1	ZNF546	19	40521413	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	5571686	40521413	18607570	169	34365										
ZFP112	7771	broad.mit.edu	37	chr19	44833549	44833549	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aggcttttctatacccagtaCatggatagggcttctcctct	8	11	3	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:44833549C>T	uc010ejj.2	-	5	892	c.779G>A	c.(778-780)TGT>TAT	p.C260Y	ZFP112_uc002ozc.3_Missense_Mutation_p.C254Y|ZFP112_uc010xwy.1_Missense_Mutation_p.C277Y|ZFP112_uc010xwz.1_Missense_Mutation_p.C259Y	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	260	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ATACCCAGTACATGGATAGGG	0.423													0	0	0	0.010771	0	44	243										T	44833549	C	T	44833549	3	4	113	1	0	0	0	0	1	0	0	0	17635	478	17	2	1966	2	ZFP112	19	44833549	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	4312136	44833549	14295434	170	34366										
PNMAL2	57469	broad.mit.edu	37	chr19	46998590	46998590	+	Missense_Mutation	SNP	G	G	A													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	caacctgaacgtgcccagggGcaggagggtcggctgcagga							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:46998590G>A	uc002pes.2	-	1	580	c.133C>T	c.(133-135)CCC>TCC	p.P45S	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	45										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		gtgcccaggggcaggagggtc	0													0	0	0	0.00874	0	39	168										A	46998590	G	A	46998590	3	1	113	1	0	0	0	0	1	0	0	0	12158	1203	42	2	1778	2	PNMAL2	19	46998590	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2165041	46998590	12130393	171	34367	177	2								
PNMAL2	57469	broad.mit.edu	37	chr19	46998594	46998594	+	Silent	SNP	G	G	A													0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctgaacgtgcccaggggcagGagggtcggctgcaggacggc							TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:46998594G>A	uc002pes.2	-	1	576	c.129C>T	c.(127-129)CTC>CTT	p.L43L	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	43										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ccaggggcaggagggtcggct	0													0	0	0	0.007835	0	38	165										A	46998594	G	A	46998594	2	1	113	1	0	0	0	0	0	0	0	1	12158	1161	41	1		1	PNMAL2	19	46998594	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	4	46998594	12130389	172	34368	177	2								
ZNF347	84671	broad.mit.edu	37	chr19	53644201	53644201	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aggctttgccatactcattaTacttgtaaggtttctctcca	6	10	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:53644201T>A	uc002qbb.1	-	5	1949	c.1880A>T	c.(1879-1881)TAT>TTT	p.Y627F	ZNF347_uc010eql.1_Missense_Mutation_p.Y628F|ZNF347_uc002qbc.1_Missense_Mutation_p.Y628F	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	627	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		ATACTCATTATACTTGTAAGG	0.378													0	0	0	0.01441	0	198	114										A	53644201	T	A	53644201	3	1	113	1	0	0	0	0	1	0	0	0	17858	1406	49	5	643	5	ZNF347	19	53644201	Missense_Mutation	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	6645607	53644201	5484782	173	34369										
ZNF134	7693	broad.mit.edu	37	chr19	58131830	58131830	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gggataaaagtgaggcctcaAttgtgaagaactgcacagtt	12	6	1	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:58131830A>G	uc002qpn.2	+	3	442	c.343A>G	c.(343-345)ATT>GTT	p.I115V	ZNF134_uc002qpo.2_5'UTR|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	115						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TGAGGCCTCAATTGTGAAGAA	0.463													0	0	0	0.01441	0	94	63										G	58131830	A	G	58131830	3	3	113	1	0	0	0	0	1	0	0	0	17721	101	4	5	349	5	ZNF134	19	58131830	Missense_Mutation	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	4487629	58131830	997153	174	34370										
PAK7	57144	broad.mit.edu	37	chr20	9561367	9561367	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttttcggtcgtgtagtcagCagtagtatcggattcgctgg	13	8	1	0	rs144997856		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:9561367C>A	uc002wnl.2	-	5	960	c.415G>T	c.(415-417)GCT>TCT	p.A139S	PAK7_uc002wnk.2_Missense_Mutation_p.A139S|PAK7_uc002wnj.2_Missense_Mutation_p.A139S|PAK7_uc010gby.1_Missense_Mutation_p.A139S	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	139	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GTGTAGTCAGCAGTAGTATCG	0.537													1	0	4.68919e-08	0.008291	4.87236e-08	10	183										A	9561367	C	A	9561367	3	1	113	1	0	0	0	0	1	0	0	0	11405	710	25	4	1772	4	PAK7	20	9561367	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		9561367	53464153	175	34371										
SSTR4	6754	broad.mit.edu	37	chr20	23017195	23017195	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	agagcaaaggtggggcagggTgcatgtgccccccactcccc	14	14	0	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:23017195T>G	uc002wsr.2	+	1	1139	c.1075T>G	c.(1075-1077)TGC>GGC	p.C359G		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	359	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGGGGCAGGGTGCATGTGCCC	0.652													0	0	0	0.013114	0	40	28										G	23017195	T	G	23017195	3	3	113	1	0	0	0	0	1	0	0	0	15199	1696	59	5	1077	5	SSTR4	20	23017195	Missense_Mutation	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	13455828	23017195	40008325	176	34372										
HCK	3055	broad.mit.edu	37	chr20	30676371	30676371	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctcccctctcccccatatagGaagcttgctggactttctga	7	15	2	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:30676371G>T	uc002wxh.2	+	10	1187	c.1016G>T	c.(1015-1017)GGA>GTA	p.G339V	HCK_uc010gdy.2_Missense_Mutation_p.G318V|HCK_uc002wxi.2_Missense_Mutation_p.G317V	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	339	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCCCATATAGGAAGCTTGCTG	0.378													1	0	6.38683e-12	0.008361	6.74166e-12	29	99										T	30676371	G	T	30676371	3	4	113	1	0	0	0	0	1	0	0	0	6994	1188	41	3	1060	3	HCK	20	30676371	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	7659176	30676371	32349149	177	34373										
RBM39	9584	broad.mit.edu	37	chr20	34312571	34312571	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctagaggcactgagctaacaTcgacgaactccacataagca	8	12	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:34312571T>C	uc002xeb.2	-	8	952	c.608A>G	c.(607-609)GAT>GGT	p.D203G	RBM39_uc002xdz.2_Missense_Mutation_p.D179G|RBM39_uc002xea.2_Missense_Mutation_p.D46G|RBM39_uc010gfn.2_Missense_Mutation_p.D46G|RBM39_uc010zvm.1_Missense_Mutation_p.D181G|RBM39_uc002xeg.2_Missense_Mutation_p.D181G|RBM39_uc002xec.2_Missense_Mutation_p.D203G|RBM39_uc002xed.2_5'UTR|RBM39_uc002xee.2_Missense_Mutation_p.D46G|RBM39_uc002xef.2_Missense_Mutation_p.D46G|RBM39_uc010zvn.1_Missense_Mutation_p.D46G	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	203	RRM 1.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TGAGCTAACATCGACGAACTC	0.413													0	0	0	0.01441	0	73	184										C	34312571	T	C	34312571	3	2	113	1	0	0	0	0	1	0	0	0	13133	1435	50	5	1024	5	RBM39	20	34312571	Missense_Mutation	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	3636200	34312571	28712949	178	34374										
DLGAP4	22839	broad.mit.edu	37	chr20	35060846	35060846	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cgcagccagccacgctacttCatgcacgcctacaacaccat	6	18	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:35060846C>A	uc002xff.2	+	3	1161	c.726C>A	c.(724-726)TTC>TTA	p.F242L	DLGAP4_uc010zvp.1_Missense_Mutation_p.F242L	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	242					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CACGCTACTTCATGCACGCCT	0.637													1	0	2.77807e-22	0.013114	3.05358e-22	41	125										A	35060846	C	A	35060846	3	1	113	1	0	0	0	0	1	0	0	0	4562	825	29	3	728	3	DLGAP4	20	35060846	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	748275	35060846	27964674	179	34375										
SLC12A5	57468	broad.mit.edu	37	chr20	44669042	44669042	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcccagccatggccatcttcAaggcagaagatgccagtggg	12	12	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:44669042A>G	uc010zxl.1	+	7	788	c.712A>G	c.(712-714)AAG>GAG	p.K238E	SLC12A5_uc002xra.2_Missense_Mutation_p.K215E|SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.K215E	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	238	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGCCATCTTCAAGGCAGAAGA	0.547													0	0	0	0.01441	0	91	282										G	44669042	A	G	44669042	3	3	113	1	0	0	0	0	1	0	0	0	14386	131	5	5	794	5	SLC12A5	20	44669042	Missense_Mutation	SNP	A	TCGA-GU-A42R-01A-11D-A23M-08	9608196	44669042	18356478	180	34376										
SLC13A3	64849	broad.mit.edu	37	chr20	45216772	45216772	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	aggaggatggcaaacatgcaGaaaaggatgaaaacagcctg	13	6	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:45216772G>C	uc002xsf.1	-	8	1085	c.1047C>G	c.(1045-1047)TTC>TTG	p.F349L	SLC13A3_uc010ghn.1_Missense_Mutation_p.F318L|SLC13A3_uc010zxw.1_Missense_Mutation_p.F299L|SLC13A3_uc002xsg.1_Missense_Mutation_p.F302L|SLC13A3_uc010gho.1_Intron|SLC13A3_uc010zxx.1_Missense_Mutation_p.F251L	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	349	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CAAACATGCAGAAAAGGATGA	0.592													0	0	0	0.003163	0	14	58										C	45216772	G	C	45216772	3	2	113	1	0	0	0	0	1	0	0	0	14393	933	33	1	785	1	SLC13A3	20	45216772	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	547730	45216772	17808748	181	34377										
KCNB1	3745	broad.mit.edu	37	chr20	47990422	47990422	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gatactctccatttcaagttCttcctttggtttgctctgtg	7	10	4	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:47990422C>G	uc002xur.1	-	2	1839	c.1675G>C	c.(1675-1677)GAA>CAA	p.E559Q	KCNB1_uc002xus.1_Missense_Mutation_p.E559Q	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	559	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATTTCAAGTTCTTCCTTTGGT	0.493													0	0	0	0.01441	0	81	174										G	47990422	C	G	47990422	3	3	113	1	0	0	0	0	1	0	0	0	8012	922	32	1	905	1	KCNB1	20	47990422	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	2773650	47990422	15035098	182	34378										
RNF160	26046	broad.mit.edu	37	chr21	30307608	30307608	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tttaatgtcatatgatagacTgaacaagccaagtgtggaat	9	5	1	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:30307608T>C	uc002ymr.2	-	27	4849	c.4836A>G	c.(4834-4836)TCA>TCG	p.S1612S		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1566							ligase activity|zinc ion binding				0						TATGATAGACTGAACAAGCCA	0.343													0	0	0	0.00245	0	15	34										C	30307608	T	C	30307608	2	2	113	1	0	0	0	0	0	0	0	1	13455	1567	55	5		5	RNF160	21	30307608	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08		30307608	17822287	183	34379										
HUNK	30811	broad.mit.edu	37	chr21	33368255	33368255	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cctccaagtccagcttccccGacaaaggtgggtcagctctg	10	15	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:33368255G>T	uc002yph.2	+	10	1840	c.1480G>T	c.(1480-1482)GAC>TAC	p.D494Y		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	494					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CAGCTTCCCCGACAAAGGTGG	0.602													1	0	7.48243e-07	0.006214	7.71444e-07	10	24										T	33368255	G	T	33368255	3	4	113	1	0	0	0	0	1	0	0	0	7458	1058	37	3	1518	3	HUNK	21	33368255	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	3060647	33368255	14761640	184	34380										
UBASH3A	53347	broad.mit.edu	37	chr21	43838679	43838679	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttcctgccggaaaactacaCggatcgagccagtgagtctg	11	12	1	1	rs141628178	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:43838679C>T	uc002zbe.2	+	7	1043	c.1007C>T	c.(1006-1008)ACG>ATG	p.T336M	UBASH3A_uc002zbf.2_Missense_Mutation_p.T298M|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.T298M	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	336	SH3.					cytosol|nucleus				ovary(3)	3						GAAAACTACACGGATCGAGCC	0.612													0	0	0	0.014323	0	20	28										T	43838679	C	T	43838679	3	4	113	1	0	0	0	0	1	0	0	0	16836	536	19	2	1033	2	UBASH3A	21	43838679	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	10470424	43838679	4291216	185	34381										
LSS	4047	broad.mit.edu	37	chr21	47648499	47648499	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cggtcttgtaggggccccctCggcgccgcagacacctgagg	15	15	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:47648499C>A	uc002zij.2	-	2	108	c.29G>T	c.(28-30)CGA>CTA	p.R10L	LSS_uc011afv.1_Missense_Mutation_p.R10L|LSS_uc002zil.2_Missense_Mutation_p.R10L|LSS_uc002zik.2_5'UTR|MCM3APAS_uc002zim.2_5'Flank|MCM3APAS_uc002zin.2_5'Flank	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	10					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GGGGCCCCCTCGGCGCCGCAG	0.746													1	0	1.23904e-05	0.000602	1.26278e-05	5	8										A	47648499	C	A	47648499	3	1	113	1	0	0	0	0	1	0	0	0	9065	884	31	3	2253	3	LSS	21	47648499	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	3809820	47648499	481396	186	34382										
PEX26	55670	broad.mit.edu	37	chr22	18567938	18567938	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcgccagctttgggactctgCggtgagccacttcttttctc	10	13	3	1	rs149153003	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:18567938C>T	uc002znp.3	+	5	937	c.728C>T	c.(727-729)GCG>GTG	p.A243V	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Missense_Mutation_p.A243V|PEX26_uc002znt.2_Intron	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	243	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						TGGGACTCTGCGGTGAGCCAC	0.542													0	0	0	0.000602	0	5	85										T	18567938	C	T	18567938	3	4	113	1	0	0	0	0	1	0	0	0	11746	768	27	2	742	2	PEX26	22	18567938	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		18567938	32736628	187	34383										
CDC45	8318	broad.mit.edu	37	chr22	19504100	19504100	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ctggtgatggctgcccccctGagcatggagcatggcacagt	14	12	0	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:19504100G>A	uc002zpr.2	+	16	1567	c.1491G>A	c.(1489-1491)CTG>CTA	p.L497L	CDC45_uc011aha.1_Silent_p.L529L|CDC45_uc002zps.2_Silent_p.L497L|CDC45_uc002zpt.2_Silent_p.L451L	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	497					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						CTGCCCCCCTGAGCATGGAGC	0.632													0	0	0	0.00333	0	22	35										A	19504100	G	A	19504100	2	1	113	1	0	0	0	0	0	0	0	1	3081	1277	45	1		1	CDC45	22	19504100	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	936162	19504100	31800466	188	34384										
COMT	1312	broad.mit.edu	37	chr22	19951738	19951738	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gacatcatcccccagctgaaGaagaagtatgatgtggacac	10	10	1	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:19951738G>A	uc002zqu.2	+	5	780	c.531G>A	c.(529-531)AAG>AAA	p.K177K	COMT_uc002zqt.2_Silent_p.K177K|COMT_uc002zqv.2_Silent_p.K177K|COMT_uc002zqw.2_Silent_p.K177K|COMT_uc011ahd.1_Silent_p.K177K|COMT_uc002zqx.2_Silent_p.K177K	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	177					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	CCCAGCTGAAGAAGAAGTATG	0.592													0	0	0	0.01441	0	61	111										A	19951738	G	A	19951738	2	1	113	1	0	0	0	0	0	0	0	1	3725	933	33	1		1	COMT	22	19951738	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	447638	19951738	31352828	189	34385										
OSM	5008	broad.mit.edu	37	chr22	30659991	30659991	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ccggctccggttcgggctctCcccccacttgctgaagaccc	10	19	1	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:30659991C>T	uc003ahb.2	-	3	692	c.640G>A	c.(640-642)GAG>AAG	p.E214K		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	214					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			TTCGGGCTCTCCCCCCACTTG	0.637													0	0	0	0.004878	0	39	59										T	30659991	C	T	30659991	3	4	113	1	0	0	0	0	1	0	0	0	11291	864	30	1	122	1	OSM	22	30659991	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	10708253	30659991	20644575	190	34386										
WNT7B	7477	broad.mit.edu	37	chr22	46319096	46319096	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tgcacggccgcgttgtacttCtccttcagcaggtggcccac	11	15	2	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:46319096C>T	uc003bgo.2	-	4	1064	c.690G>A	c.(688-690)GAG>GAA	p.E230E	WNT7B_uc010haa.2_Silent_p.E234E	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	230					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CGTTGTACTTCTCCTTCAGCA	0.642													0	0	0	0.003271	0	31	43										T	46319096	C	T	46319096	2	4	113	1	0	0	0	0	0	0	0	1	17392	912	32	1		1	WNT7B	22	46319096	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	15659105	46319096	4985470	191	34387										
RPGR	6103	broad.mit.edu	37	chrX	38135986	38135986	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	attaatttcctcatccacatCttctagttttagttcctcag	3	11	4	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:38135986C>G	uc004deb.2	-	16	2113	c.1945G>C	c.(1945-1947)GAT>CAT	p.D649H	RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_000328	NP_000319	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCATCCACATCTTCTAGTTTT	0.353													0	0	0	0.005524	0	40	21										G	38135986	C	G	38135986	3	3	113	1	0	0	0	0	1	0	0	0	13548	913	32	1	518	1	RPGR	23	38135986	Missense_Mutation	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08		38135986	117134574	192	34388										
KDM6A	7403	broad.mit.edu	37	chrX	44966676	44966676	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tattgtcttctaagaactctGaagcaatgtcagacattgag	8	7	4	4			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:44966676G>A	uc004dge.3	+	27	4275	c.3900G>A	c.(3898-3900)CTG>CTA	p.L1300L	KDM6A_uc011mkz.1_Silent_p.L1352L|KDM6A_uc011mla.1_Silent_p.L1255L|KDM6A_uc011mlb.1_Silent_p.L1307L|KDM6A_uc011mlc.1_Silent_p.L1004L|KDM6A_uc011mld.1_Silent_p.L939L	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1300					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAAGAACTCTGAAGCAATGTC	0.373			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.01441	0	66	18										A	44966676	G	A	44966676	2	1	113	1	0	0	0	0	0	0	0	1	8137	1277	45	1		1	KDM6A	23	44966676	Silent	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	6830690	44966676	110303884	193	34389										
KDM6A	7403	broad.mit.edu	37	chrX	44969330	44969330	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	cttgtataaaacaggtggagGtttttgatctgctttttgtc	10	5	1	1			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:44969330G>T	uc004dge.3	+	28	4387	c.4012G>T	c.(4012-4014)GTT>TTT	p.V1338F	KDM6A_uc011mkz.1_Missense_Mutation_p.V1390F|KDM6A_uc011mla.1_Missense_Mutation_p.V1293F|KDM6A_uc011mlb.1_Missense_Mutation_p.V1345F|KDM6A_uc011mlc.1_Missense_Mutation_p.V1042F|KDM6A_uc011mld.1_Missense_Mutation_p.V977F	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1338					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						ACAGGTGGAGGTTTTTGATCT	0.338			D|N|F|S		renal|oesophageal SCC|MM								1	0	1.08052e-11	0.004289	1.13604e-11	36	23										T	44969330	G	T	44969330	3	4	113	1	0	0	0	0	1	0	0	0	8137	1261	44	4	4122	4	KDM6A	23	44969330	Missense_Mutation	SNP	G	TCGA-GU-A42R-01A-11D-A23M-08	2654	44969330	110301230	194	34390										
CCDC120	90060	broad.mit.edu	37	chrX	48925201	48925201	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	tcccgccgggatgggctcctCaccatgctccccggcccacc	10	21	1	0			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:48925201C>T	uc010nik.2	+	10	1953	c.1446C>T	c.(1444-1446)CTC>CTT	p.L482L	CCDC120_uc011mmq.1_Silent_p.L470L|CCDC120_uc004dmf.2_Silent_p.L482L|CCDC120_uc010nil.2_Silent_p.L482L|CCDC120_uc011mmr.1_Silent_p.L482L|CCDC120_uc011mms.1_Silent_p.L470L	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	482	Pro-rich.						protein binding			pancreas(1)	1						ATGGGCTCCTCACCATGCTCC	0.711													0	0	0	0.00278	0	21	9										T	48925201	C	T	48925201	2	4	113	1	0	0	0	0	0	0	0	1	2756	813	29	1		1	CCDC120	23	48925201	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	3955871	48925201	106345359	195	34391										
MED12	9968	broad.mit.edu	37	chrX	70351453	70351453	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	ttggagctgcagctcatgatCaagcagacccctaacaatgt	9	11	2	2			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:70351453C>T	uc004dyy.2	+	29	4300	c.4101C>T	c.(4099-4101)ATC>ATT	p.I1367I	MED12_uc011mpq.1_Silent_p.I1367I|MED12_uc004dyz.2_Silent_p.I1367I|MED12_uc004dza.2_Silent_p.I1214I|MED12_uc010nla.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1367					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AGCTCATGATCAAGCAGACCC	0.562													0	0	0	0.010818	0	27	11										T	70351453	C	T	70351453	2	4	113	1	0	0	0	0	0	0	0	1	9428	816	29	1		1	MED12	23	70351453	Silent	SNP	C	TCGA-GU-A42R-01A-11D-A23M-08	21426252	70351453	84919107	196	34392										
RLIM	51132	broad.mit.edu	37	chrX	73812256	73812256	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.394871794871795	77	6.75443669261188e-26	3.67057754075511	4.93723324127542	3.0240553602812	0.355292149207636	0.570221967864107	56	gcagctgtgtctgaagaaccTgctccttgagaagcatttct	10	10	2	3			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:73812256T>C	uc004ebu.2	-	5	1184	c.894A>G	c.(892-894)GCA>GCG	p.A298A	RLIM_uc004ebw.2_Silent_p.A298A	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	298					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTGAAGAACCTGCTCCTTGAG	0.488													0	0	0	0.003755	0	34	15										C	73812256	T	C	73812256	2	2	113	1	0	0	0	0	0	0	0	1	13390	1567	55	5		5	RLIM	23	73812256	Silent	SNP	T	TCGA-GU-A42R-01A-11D-A23M-08	3460803	73812256	81458304	197	34393										
CLCN6	1185	broad.mit.edu	37	chr1	11867207	11867207	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gaccatccttggagaaacacAggaggaggaggatgagattc	14	7	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:11867207A>G	uc001ate.3	+	2	220	c.107A>G	c.(106-108)CAG>CGG	p.Q36R	MTHFR_uc001atc.1_5'Flank|MTHFR_uc001atd.1_5'Flank|MTHFR_uc009vnd.1_5'Flank|CLCN6_uc009vne.1_Missense_Mutation_p.Q36R|CLCN6_uc009vnf.1_Missense_Mutation_p.Q36R|CLCN6_uc009vng.1_Missense_Mutation_p.Q36R|CLCN6_uc009vnh.1_Missense_Mutation_p.Q36R|CLCN6_uc010oat.1_5'UTR|CLCN6_uc010oau.1_Missense_Mutation_p.Q36R	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	36	Cytoplasmic (By similarity).				cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGAAACACAGGAGGAGGAG	0.473													0	0	0	0.010818	0	23	14										G	11867207	A	G	11867207	3	3	114	1	0	0	0	0	1	0	0	0	3467	188	7	5	113	5	CLCN6	1	11867207	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08		11867207	237383414	1	34394										
ARID1A	8289	broad.mit.edu	37	chr1	27100375	27100375	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gccagcagactacaatgtatCaacagcaacagcaggtgagg	11	10	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:27100375C>T	uc001bmv.1	+	17	4460	c.4087C>T	c.(4087-4089)CAA>TAA	p.Q1363*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1362*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1363*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q980*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q209*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1363	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TACAATGTATCAACAGCAACA	0.488			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	121	96										T	27100375	C	T	27100375	4	4	114	1	0	0	0	0	0	1	0	0	913	827	29	1	4153	1	ARID1A	1	27100375	Nonsense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	15233168	27100375	222150246	2	34395										
ROR1	4919	broad.mit.edu	37	chr1	64643579	64643579	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tccacaaggaccttgcagctCgcaatattttaatcggagag	9	10	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:64643579C>T	uc001dbj.2	+	9	2254	c.1855C>T	c.(1855-1857)CGC>TGC	p.R619C	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	619	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						CCTTGCAGCTCGCAATATTTT	0.453													0	0	0	0.016723	0	13	28										T	64643579	C	T	64643579	3	4	114	1	0	0	0	0	1	0	0	0	13526	884	31	1	1897	1	ROR1	1	64643579	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	37543204	64643579	184607042	3	34396										
ST6GALNAC5	81849	broad.mit.edu	37	chr1	77510286	77510286	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgagctcttcaagcaggagaCtggcaaagacaggtacaaag	12	8	2	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:77510286C>A	uc001dhi.2	+	3	834	c.659C>A	c.(658-660)ACT>AAT	p.T220N	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	220	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						AAGCAGGAGACTGGCAAAGAC	0.527													1	0	5.35356e-11	0.016522	5.80548e-11	20	216										A	77510286	C	A	77510286	3	1	114	1	0	0	0	0	1	0	0	0	15226	565	20	4	669	4	ST6GALNAC5	1	77510286	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	12866707	77510286	171740335	4	34397										
IFI44	10561	broad.mit.edu	37	chr1	79115948	79115948	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaatcattttggagggaagcGgcttagccttctctataagg	11	7	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:79115948G>A	uc001dip.3	+	2	192	c.68G>A	c.(67-69)CGG>CAG	p.R23Q	IFI44_uc010orr.1_Missense_Mutation_p.R23Q|IFI44_uc010ors.1_Intron	NM_006417	NP_006408	Q8TCB0	IFI44_HUMAN	interferon-induced, hepatitis C-associated	23					response to virus	cytoplasm				ovary(1)|central_nervous_system(1)	2						GGAGGGAAGCGGCTTAGCCTT	0.403													0	0	0	0.012319	0	19	55										A	79115948	G	A	79115948	3	1	114	1	0	0	0	0	1	0	0	0	7517	1116	39	2	70	2	IFI44	1	79115948	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	1605662	79115948	170134673	5	34398										
DPYD	1806	broad.mit.edu	37	chr1	98187182	98187182	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	taccattccacaagtcagacCaagtgggttgtcagaaaata	8	9	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:98187182C>A	uc001drv.2	-	5	504	c.367G>T	c.(367-369)GGT>TGT	p.G123C	DPYD_uc010oub.1_RNA|DPYD_uc001drw.2_Missense_Mutation_p.G123C	NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	123					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CAAGTCAGACCAAGTGGGTTG	0.348													1	0	4.34086e-07	0.023175	4.58813e-07	32	51										A	98187182	C	A	98187182	3	1	114	1	0	0	0	0	1	0	0	0	4745	594	21	4	2829	4	DPYD	1	98187182	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	19071234	98187182	151063439	6	34399										
DENND4B	9909	broad.mit.edu	37	chr1	153915377	153915377	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gccagggttgaggttgcgggGcagccggcagtaagtatgag	19	7	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:153915377G>A	uc001fdd.1	-	3	948	c.547C>T	c.(547-549)CCC>TCC	p.P183S		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	183	MABP.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGGTTGCGGGGCAGCCGGCAG	0.632													0	0	0	0.009096	0	3	43										A	153915377	G	A	153915377	3	1	114	1	0	0	0	0	1	0	0	0	4434	1203	42	2	4047	2	DENND4B	1	153915377	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	55728195	153915377	95335244	7	34400										
TNR	7143	broad.mit.edu	37	chr1	175372615	175372615	+	Frame_Shift_Del	DEL	C	C	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcactggccatccacacacaCcccccggctggagcaaccca							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:175372615delC	uc001gkp.1	-	2	718	c.637delG	c.(637-639)GTGfs	p.V213fs	TNR_uc009wwu.1_Frame_Shift_Del_p.V213fs|TNR_uc010pmz.1_Frame_Shift_Del_p.V213fs	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	213	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCACACACACCCCCCGGCTG	0.607																		7	611	---	---								-	175372615	C	-	175372615	7	5	114	1	0	1	0	1	0	0	0	0	16335	507	18	0	3519	0	TNR	1	175372615	Frame_Shift_Del	DEL	C	TCGA-GV-A3JV-01A-11D-A21Z-08	21457238	175372615	73878006	8	34401										
CACNA1S	779	broad.mit.edu	37	chr1	201029886	201029886	+	Frame_Shift_Del	DEL	T	T	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	acacctggtactggtatgggTttttgggaatgtagcacctc							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:201029886delT	uc001gvv.2	-	26	3541	c.3314delA	c.(3313-3315)AACfs	p.N1105fs		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1105	Cytoplasmic (Potential).|IV.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTGGTATGGGTTTTTGGGAAT	0.532																		7	785	---	---								-	201029886	T	-	201029886	7	5	114	1	0	1	0	1	0	0	0	0	2547	1725	60	0	2383	0	CACNA1S	1	201029886	Frame_Shift_Del	DEL	T	TCGA-GV-A3JV-01A-11D-A21Z-08	25657271	201029886	48220735	9	34402										
ELF3	1999	broad.mit.edu	37	chr1	201981520	201981521	+	Frame_Shift_Ins	INS	-	-	G													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atcattgagctgctggagaaINSggatggcatggccttccagg							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:201981520_201981521insG	uc001gxg.3	+	3	3626_3627	c.434_435insG	c.(433-435)AAGfs	p.K145fs	ELF3_uc001gxi.3_Frame_Shift_Ins_p.K145fs|ELF3_uc001gxh.3_Frame_Shift_Ins_p.K145fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	145	9aaTAD.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CTGCTGGAGAAGGATGGCATGG	0.579																		25	184	---	---								G	201981521	-	G	201981520	7	5	114	1	0	1	1	0	0	0	0	0	5055	72	3	0	444	0	ELF3	1	201981520	Frame_Shift_Ins	INS	-	TCGA-GV-A3JV-01A-11D-A21Z-08	951634	201981520	47269101	10	34403										
ELF3	1999	broad.mit.edu	37	chr1	201983142	201983142	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgacctacgagaagctgagcCgggccatgaggtgagctggc	16	10	0	5			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:201983142C>T	uc001gxg.3	+	7	4183	c.991C>T	c.(991-993)CGG>TGG	p.R331W	ELF3_uc001gxi.3_Missense_Mutation_p.R331W|ELF3_uc001gxh.3_Missense_Mutation_p.R331W	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	331	ETS.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						GAAGCTGAGCCGGGCCATGAG	0.607													0	0	0	0.024245	0	13	9										T	201983142	C	T	201983142	3	4	114	1	0	0	0	0	1	0	0	0	5055	643	23	2	1017	2	ELF3	1	201983142	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	1622	201983142	47267479	11	34404										
PRSS38	339501	broad.mit.edu	37	chr1	228005156	228005156	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	agtgccaattgctgggctacGggatggggactagtctcaaa	14	8	1	0	rs139000968	by1000genomes	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:228005156G>A	uc001hrh.2	+	3	558	c.558G>A	c.(556-558)ACG>ACA	p.T186T		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	186	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						GCTGGGCTACGGGATGGGGAC	0.527													0	0	0	0.020292	0	12	74										A	228005156	G	A	228005156	2	1	114	1	0	0	0	0	0	0	0	1	12627	1103	39	2		2	PRSS38	1	228005156	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	26022014	228005156	21245465	12	34405										
LYST	1130	broad.mit.edu	37	chr1	235922848	235922848	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atgctggtaggcttctagaaCgcagcatatgggcggccatc	13	10	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:235922848C>T	uc001hxj.2	-	23	6480	c.6305G>A	c.(6304-6306)CGT>CAT	p.R2102H	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2102					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCTTCTAGAACGCAGCATATG	0.378									Chediak-Higashi_syndrome				0	0	0	0.00499	0	14	66										T	235922848	C	T	235922848	3	4	114	1	0	0	0	0	1	0	0	0	9128	536	19	2	5224	2	LYST	1	235922848	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	7917692	235922848	13327773	13	34406										
OR2T12	127064	broad.mit.edu	37	chr1	248458734	248458735	+	Missense_Mutation	DNP	CC	CC	AA													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ggcctgtggagccggtggtcCcagtgaatcaggagaatcat							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr1:248458734_248458735CC>AA	uc010pzj.1	-	1	146_147	c.146_147GG>TT	c.(145-147)TGG>TTT	p.W49F		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GCCGGTGGTCCCAGTGAATCAG	0.535													0	0	0	0.004672	0	22	33										AA	248458735	CC	AA	248458734	3	1	114	1	0	0	0	0	1	0	0	0	11019	624	22	4	818	4	OR2T12	1	248458734	Missense_Mutation	DNP	CC	TCGA-GV-A3JV-01A-11D-A21Z-08	12535886	248458734	791887	14	34407										
TPO	7173	broad.mit.edu	37	chr2	1497623	1497623	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctgcctcgcctggagaccccCgctgacctgagcacagccat	10	18	0	3	rs148782927	by1000genomes	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr2:1497623C>T	uc002qww.2	+	11	1909	c.1818C>T	c.(1816-1818)CCC>CCT	p.P606P	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Silent_p.P549P|TPO_uc002qwr.2_Silent_p.P606P|TPO_uc002qwx.2_Silent_p.P549P|TPO_uc010yio.1_Silent_p.P433P|TPO_uc010yip.1_Silent_p.P606P|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	606	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGGAGACCCCCGCTGACCTGA	0.577													0	0	0	0.010729	0	11	17										T	1497623	C	T	1497623	2	4	114	1	0	0	0	0	0	0	0	1	16407	639	23	2		2	TPO	2	1497623	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		1497623	241701750	15	34408										
SLC6A1	6529	broad.mit.edu	37	chr3	11058951	11058951	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cagatctccaccgaggtcagCgaggcccctgtggccaatga	12	14	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:11058951C>T	uc010hdq.2	+	3	465	c.54C>T	c.(52-54)AGC>AGT	p.S18S		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	18	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CCGAGGTCAGCGAGGCCCCTG	0.637													0	0	0	0.013537	0	12	65										T	11058951	C	T	11058951	2	4	114	1	0	0	0	0	0	0	0	1	14673	767	27	2		2	SLC6A1	3	11058951	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		11058951	186963479	16	34409										
NUP210	23225	broad.mit.edu	37	chr3	13376966	13376966	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cctcctacctggacttggatCtcatccgagagttctctggc	9	14	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13376966C>T	uc003bxv.1	-	28	3914	c.3831G>A	c.(3829-3831)GAG>GAA	p.E1277E		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1277	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GGACTTGGATCTCATCCGAGA	0.627													0	0	0	0.017118	0	25	184										T	13376966	C	T	13376966	2	4	114	1	0	0	0	0	0	0	0	1	10760	912	32	1		1	NUP210	3	13376966	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	2318015	13376966	184645464	17	34410			1	158		5	4	109	N	C	2.054109e-11
NUP210	23225	broad.mit.edu	37	chr3	13376980	13376980	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttggatctcatccgagagttCtctggccaggccatacagct	10	12	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13376980C>T	uc003bxv.1	-	28	3900	c.3817G>A	c.(3817-3819)GAA>AAA	p.E1273K		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1273	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TCCGAGAGTTCTCTGGCCAGG	0.632													0	0	0	0.024334	0	15	164										T	13376980	C	T	13376980	3	4	114	1	0	0	0	0	1	0	0	0	10760	922	32	1	1898	1	NUP210	3	13376980	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	14	13376980	184645450	18	34411			1	158		5	4	109	N	C	2.054109e-11
NUP210	23225	broad.mit.edu	37	chr3	13377022	13377022	+	Missense_Mutation	SNP	C	C	T													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccccgatgtggggtccacagCcttgaccaccaccctcagcc					rs146409293		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13377022C>T	uc003bxv.1	-	28	3858	c.3775G>A	c.(3775-3777)GCT>ACT	p.A1259T		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1259	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GGGTCCACAGCCTTGACCACC	0.617													0	0	0	0.013537	0	9	110										T	13377022	C	T	13377022	3	4	114	1	0	0	0	0	1	0	0	0	10760	739	26	2	1940	2	NUP210	3	13377022	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	42	13377022	184645408	19	34412	178	2	1	158		5	4	109	N	C	2.054109e-11
NUP210	23225	broad.mit.edu	37	chr3	13377029	13377029	+	Silent	SNP	C	C	T													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtggggtccacagccttgacCaccaccctcagcccggtccg							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13377029C>T	uc003bxv.1	-	28	3851	c.3768G>A	c.(3766-3768)GTG>GTA	p.V1256V		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1256	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CAGCCTTGACCACCACCCTCA	0.602													0	0	0	0.008291	0	8	112										T	13377029	C	T	13377029	2	4	114	1	0	0	0	0	0	0	0	1	10760	581	21	2		2	NUP210	3	13377029	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	7	13377029	184645401	20	34413	178	2	1	158		5	4	109	N	C	2.054109e-11
NUP210	23225	broad.mit.edu	37	chr3	13377074	13377074	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tttacccggccgagcacgttCatggcaaagttgtactgtga	11	10	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13377074C>T	uc003bxv.1	-	28	3806	c.3723G>A	c.(3721-3723)ATG>ATA	p.M1241I		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1241	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CGAGCACGTTCATGGCAAAGT	0.602													0	0	0	0.010729	0	9	99										T	13377074	C	T	13377074	3	4	114	1	0	0	0	0	1	0	0	0	10760	826	29	1	1992	1	NUP210	3	13377074	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	45	13377074	184645356	21	34414			1	158		5	4	109	N	C	2.054109e-11
FBLN2	2199	broad.mit.edu	37	chr3	13612699	13612701	+	In_Frame_Del	DEL	GAG	GAG	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aggacagtgaggaggaagaaGaggaggaggaggagagagag							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:13612699_13612701delGAG	uc011avb.1	+	2	969_971	c.844_846delGAG	c.(844-846)GAGdel	p.E286del	FBLN2_uc011auz.1_In_Frame_Del_p.E312del|FBLN2_uc011ava.1_In_Frame_Del_p.E286del|FBLN2_uc011avc.1_In_Frame_Del_p.E286del	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	286	Subdomain NB (Cys-free).|N.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			ggaggaagaagaggaggaggagg	0.557																		7	350	---	---								-	13612701	GAG	-	13612699	7	5	114	1	0	1	0	1	0	0	0	0	5699	943	33	0		0	FBLN2	3	13612699	In_Frame_Del	DEL	GAG	TCGA-GV-A3JV-01A-11D-A21Z-08	235625	13612699	184409731	22	34415										
MAP4	4134	broad.mit.edu	37	chr3	47913557	47913558	+	In_Frame_Ins	INS	-	-	CCG													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gctggcttggatggtgaggcINSccgcttctcaggagcctttg							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:47913557_47913558insCCG	uc003csb.2	-	11	2881_2882	c.2355_2356insCGG	c.(2353-2358)insCGG	p.785_786insR	MAP4_uc003csc.3_In_Frame_Ins_p.785_786insR|MAP4_uc003crw.2_5'Flank|MAP4_uc003crx.2_In_Frame_Ins_p.45_46insR|MAP4_uc011bbe.1_In_Frame_Ins_p.536_537insR|MAP4_uc003cry.2_In_Frame_Ins_p.520_521insR|MAP4_uc003csa.3_In_Frame_Ins_p.520_521insR|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_In_Frame_Ins_p.520_521insR	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	785_786					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GATGGTGAGGCCCGCTTCTCAG	0.55																		74	256	---	---								CCG	47913558	-	CCG	47913557	7	5	114	1	0	1	1	0	0	0	0	0	9258	739	26	0	1289	0	MAP4	3	47913557	In_Frame_Ins	INS	-	TCGA-GV-A3JV-01A-11D-A21Z-08	34300858	47913557	150108873	23	34416										
PTPRG	5793	broad.mit.edu	37	chr3	61989042	61989042	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtcgccatccttctgaaagaCgactattttgtcagtggagc	10	10	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:61989042C>T	uc003dlb.2	+	4	1109	c.390C>T	c.(388-390)GAC>GAT	p.D130D	PTPRG_uc003dlc.2_Silent_p.D130D	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	130	Extracellular (Potential).|Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TTCTGAAAGACGACTATTTTG	0.438													0	0	0	0.007291	0	22	72										T	61989042	C	T	61989042	2	4	114	1	0	0	0	0	0	0	0	1	12802	535	19	2		2	PTPRG	3	61989042	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	14075485	61989042	136033388	24	34417										
FAM19A1	407738	broad.mit.edu	37	chr3	68466476	68466476	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcacaccgatgttgtaacaaGaatcgcattgaggagcggtc	12	9	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:68466476G>A	uc003dnd.2	+	3	381	c.165G>A	c.(163-165)AAG>AAA	p.K55K	FAM19A1_uc003dne.2_Silent_p.K55K|FAM19A1_uc003dng.2_Silent_p.K55K	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	55						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		GTTGTAACAAGAATCGCATTG	0.468													0	0	0	0.00632	0	27	41										A	68466476	G	A	68466476	2	1	114	1	0	0	0	0	0	0	0	1	5531	933	33	1		1	FAM19A1	3	68466476	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	6477434	68466476	129555954	25	34418										
MORC1	27136	broad.mit.edu	37	chr3	108682322	108682322	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gattcttcagcttatcctcaGagatttttcttttattttca	4	8	5	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:108682322G>C	uc003dxl.2	-	27	2825	c.2738C>G	c.(2737-2739)TCT>TGT	p.S913C	MORC1_uc011bhn.1_Missense_Mutation_p.S892C	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	913	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTTATCCTCAGAGATTTTTCT	0.294													0	0	0	0.01441	0	38	55										C	108682322	G	C	108682322	3	2	114	1	0	0	0	0	1	0	0	0	9701	942	33	1	224	1	MORC1	3	108682322	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	40215846	108682322	89340108	26	34419										
C3orf15	89876	broad.mit.edu	37	chr3	119445049	119445049	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccagcaggacaagctgaggtGgagatgatagaaagagcccg	15	8	0	5			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:119445049G>A	uc003ede.3	+	7	791	c.714G>A	c.(712-714)GTG>GTA	p.V238V	C3orf15_uc010hqy.1_Silent_p.V238V|C3orf15_uc010hqz.2_Silent_p.V176V|C3orf15_uc011bjd.1_Silent_p.V112V|C3orf15_uc011bje.1_Silent_p.V218V|C3orf15_uc010hra.1_5'UTR	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	238						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		AAGCTGAGGTGGAGATGATAG	0.532													0	0	0	0.024245	0	14	28										A	119445049	G	A	119445049	2	1	114	1	0	0	0	0	0	0	0	1	2209	1335	47	2		2	C3orf15	3	119445049	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	10762727	119445049	78577381	27	34420										
ZIC1	7545	broad.mit.edu	37	chr3	147127954	147127954	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcggcgtgaccacctttggcGcgtcccgccaccactccgcg	11	19	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:147127954G>A	uc003ewe.2	+	1	774	c.55G>A	c.(55-57)GCG>ACG	p.A19T		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	19					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A19A(1)		ovary(1)|central_nervous_system(1)	2						CACCTTTGGCGCGTCCCGCCA	0.741													0	0	0	0.020292	0	12	37										A	147127954	G	A	147127954	3	1	114	1	0	0	0	0	1	0	0	0	17675	1087	38	2	57	2	ZIC1	3	147127954	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	27682905	147127954	50894476	28	34421										
ARPM1	84517	broad.mit.edu	37	chr3	169485270	169485270	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tccaacttctttaaattctgCagcagtgatccacatgtcct	5	12	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:169485270C>T	uc003ffs.1	-	2	1444	c.1069G>A	c.(1069-1071)GCA>ACA	p.A357T	TERC_uc003ffr.1_5'Flank	NM_032487	NP_115876	Q9BYD9	ARPM1_HUMAN	actin related protein M1	357						cytoplasm|cytoskeleton					0	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;5.01e-59)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TTAAATTCTGCAGCAGTGATC	0.398													0	0	0	0.00499	0	14	195										T	169485270	C	T	169485270	3	4	114	1	0	0	0	0	1	0	0	0	976	710	25	2	53	2	ARPM1	3	169485270	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	22357316	169485270	28537160	29	34422										
TP63	8626	broad.mit.edu	37	chr3	189455639	189455639	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tccagaggttttccagcataTctgggattttctggaacagt	10	8	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr3:189455639T>C	uc003fry.2	+	2	262	c.173T>C	c.(172-174)ATC>ACC	p.I58T	TP63_uc003frx.2_Missense_Mutation_p.I58T|TP63_uc003frz.2_Missense_Mutation_p.I58T|TP63_uc010hzc.1_Missense_Mutation_p.I58T	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	58	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TTCCAGCATATCTGGGATTTT	0.403									Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.028581	0	14	51										C	189455639	T	C	189455639	3	2	114	1	0	0	0	0	1	0	0	0	16389	1435	50	5	179	5	TP63	3	189455639	Missense_Mutation	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08	19970369	189455639	8566791	30	34423										
CRMP1	1400	broad.mit.edu	37	chr4	5837699	5837699	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcggggtcccagatgaccacGtcggcatccgagcccacggc	13	16	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:5837699G>A	uc003gip.2	-	12	1325	c.1224C>T	c.(1222-1224)GAC>GAT	p.D408D	CRMP1_uc003gin.1_Silent_p.D320D|CRMP1_uc003giq.2_Silent_p.D408D|CRMP1_uc003gir.2_Silent_p.D403D|CRMP1_uc003gis.2_Silent_p.D522D	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	408					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		AGATGACCACGTCGGCATCCG	0.517													0	0	0	0.015359	0	33	84										A	5837699	G	A	5837699	2	1	114	1	0	0	0	0	0	0	0	1	3890	1136	40	2		2	CRMP1	4	5837699	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		5837699	185316577	31	34424										
LGI2	55203	broad.mit.edu	37	chr4	25005321	25005321	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaagggctgcagggtcatggCcccccgggatggaagagctt	16	10	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:25005321C>A	uc003grf.2	-	8	1489	c.1390G>T	c.(1390-1392)GCC>TCC	p.A464S		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	464	EAR 6.					extracellular region					0		Breast(46;0.173)				AGGGTCATGGCCCCCCGGGAT	0.512													1	0	3.00307e-07	0.008361	3.19434e-07	27	146										A	25005321	C	A	25005321	3	1	114	1	0	0	0	0	1	0	0	0	8752	739	26	4	251	4	LGI2	4	25005321	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	19167622	25005321	166148955	32	34425										
TBC1D1	23216	broad.mit.edu	37	chr4	38016441	38016441	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcccagcccggcctgcgctcGctggcctttaggaaggagct	13	15	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:38016441G>A	uc003gtb.2	+	3	1072	c.729G>A	c.(727-729)TCG>TCA	p.S243S	TBC1D1_uc011byd.1_Silent_p.S243S|TBC1D1_uc010ifd.2_Intron|TBC1D1_uc011byf.1_Silent_p.S114S	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	243						nucleus	Rab GTPase activator activity			ovary(1)	1						GCCTGCGCTCGCTGGCCTTTA	0.672													0	0	0	0.001984	0	7	7										A	38016441	G	A	38016441	2	1	114	1	0	0	0	0	0	0	0	1	15594	1074	38	2		2	TBC1D1	4	38016441	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	13011120	38016441	153137835	33	34426										
FRYL	285527	broad.mit.edu	37	chr4	48549697	48549697	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaggacagaagcaacagttcGgatgttactattgggtccca	11	8	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:48549697G>A	uc003gyh.1	-	41	5583	c.4978C>T	c.(4978-4980)CGA>TGA	p.R1660*	FRYL_uc003gyg.1_Nonsense_Mutation_p.R356*|FRYL_uc003gyi.1_Nonsense_Mutation_p.R549*|FRYL_uc003gyj.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1660					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GCAACAGTTCGGATGTTACTA	0.418													0	0	0	0.013537	0	12	37										A	48549697	G	A	48549697	4	1	114	1	0	0	0	0	0	1	0	0	6064	1124	39	2	4159	2	FRYL	4	48549697	Nonsense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	10533256	48549697	142604579	34	34427										
PDGFRA	5156	broad.mit.edu	37	chr4	55140704	55140704	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctcttgtcacgtagccctgcGttctgaactcacggtggctg	11	13	4	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:55140704G>A	uc003han.3	+	11	1896	c.1565G>A	c.(1564-1566)CGT>CAT	p.R522H	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.R416H|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_5'Flank	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	522	Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GTAGCCCTGCGTTCTGAACTC	0.498			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.009535	0	27	83										A	55140704	G	A	55140704	3	1	114	1	0	0	0	0	1	0	0	0	11661	1145	40	2	1603	2	PDGFRA	4	55140704	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	6591007	55140704	136013572	35	34428										
SORBS2	8470	broad.mit.edu	37	chr4	186545479	186545479	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtgctgctccagatttctgcGttttgccgggccatttgcca	11	12	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr4:186545479G>A	uc003iyl.2	-	13	1950	c.1092C>T	c.(1090-1092)AAC>AAT	p.N364N	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Silent_p.N464N|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Silent_p.N268N|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Silent_p.N478N|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	364						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGATTTCTGCGTTTTGCCGGG	0.517													0	0	0	0.009096	0	3	55										A	186545479	G	A	186545479	2	1	114	1	0	0	0	0	0	0	0	1	14928	1136	40	2		2	SORBS2	4	186545479	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	131404775	186545479	4608797	36	34429										
SLC9A3	6550	broad.mit.edu	37	chr5	482184	482184	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccccagccccgcacttacgCgcccgtgcagcttctcgttg	9	20	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:482184C>T	uc003jbe.2	-	8	1557	c.1445G>A	c.(1444-1446)CGC>CAC	p.R482H	SLC9A3_uc011clx.1_Missense_Mutation_p.R473H	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	482	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGCACTTACGCGCCCGTGCAG	0.692													0	0	0	0.014758	0	3	25										T	482184	C	T	482184	3	4	114	1	0	0	0	0	1	0	0	0	14713	782	27	2	1099	2	SLC9A3	5	482184	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		482184	180433076	37	34430										
SLC9A3	6550	broad.mit.edu	37	chr5	484634	484634	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcgtgtgtgggagggactcaCgcgaggatggccgacagcga	19	9	1	0	rs144524702		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:484634C>T	uc003jbe.2	-	5	1044	c.932_splice	c.e5+1	p.A311_splice	SLC9A3_uc011clx.1_Splice_Site_p.A311_splice	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen							cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GAGGGACTCACGCGAGGATGG	0.642													0	0	0	0.010504	0	17	31										T	484634	C	T	484634	5	4	114	1	0	0	0	0	0	0	1	0	14713	550	19	2	1623	2	SLC9A3	5	484634	Splice_Site	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	2450	484634	180430626	38	34431										
SLC6A18	348932	broad.mit.edu	37	chr5	1232401	1232401	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccattttccacgtcgagctCgccatcggccagcggctgcg	11	17	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:1232401C>T	uc003jby.1	+	2	351	c.228C>T	c.(226-228)CTC>CTT	p.L76L		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	76	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			ACGTCGAGCTCGCCATCGGCC	0.667													0	0	0	0.014758	0	3	38										T	1232401	C	T	1232401	2	4	114	1	0	0	0	0	0	0	0	1	14681	871	31	1		1	SLC6A18	5	1232401	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	747767	1232401	179682859	39	34432										
MAP3K1	4214	broad.mit.edu	37	chr5	56177590	56177590	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	acttcaccaggatgcgtcgcCgtttgatggctattgcagat	11	10	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:56177590C>T	uc003jqw.3	+	14	3064	c.2563C>T	c.(2563-2565)CGT>TGT	p.R855C		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	855					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		GATGCGTCGCCGTTTGATGGC	0.478													0	0	0	0.010729	0	8	80										T	56177590	C	T	56177590	3	4	114	1	0	0	0	0	1	0	0	0	9243	652	23	2	2617	2	MAP3K1	5	56177590	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	54945189	56177590	124737670	40	34433										
MEGF10	84466	broad.mit.edu	37	chr5	126781188	126781188	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaatctgaacagcttaagccGaaccagtactgctctccctg	7	13	2	1	rs138372925		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:126781188G>T	uc003kuh.3	+	21	2893	c.2531G>T	c.(2530-2532)CGA>CTA	p.R844L	MEGF10_uc003kui.3_Missense_Mutation_p.R844L	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	844	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGCTTAAGCCGAACCAGTACT	0.438													1	0	1.51926e-22	0.01441	1.68024e-22	39	45										T	126781188	G	T	126781188	3	4	114	1	0	0	0	0	1	0	0	0	9460	1058	37	3	2605	3	MEGF10	5	126781188	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	70603598	126781188	54134072	41	34434										
KDM3B	51780	broad.mit.edu	37	chr5	137761242	137761242	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttccgatgtgaaagttcgggAtttctgggatggtttcgaga	14	5	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:137761242A>G	uc003lcy.1	+	17	4582	c.4382A>G	c.(4381-4383)GAT>GGT	p.D1461G	KDM3B_uc010jew.1_Missense_Mutation_p.D1117G|KDM3B_uc011cys.1_Missense_Mutation_p.D493G	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1461					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						AAAGTTCGGGATTTCTGGGAT	0.453													0	0	0	0.01441	0	51	43										G	137761242	A	G	137761242	3	3	114	1	0	0	0	0	1	0	0	0	8127	333	12	5	4448	5	KDM3B	5	137761242	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08	10980054	137761242	43154018	42	34435										
PCDHGA2	56113	broad.mit.edu	37	chr5	140719540	140719540	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctaaccagagcgaaggttatCgtcacggttctggatgtgaa	12	8	2	2	rs149528645		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:140719540C>T	uc003ljk.1	+	1	1187	c.1002C>T	c.(1000-1002)ATC>ATT	p.I334I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.I334I	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	334	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAAGGTTATCGTCACGGTTC	0.428													0	0	0	0.013114	0	41	135										T	140719540	C	T	140719540	2	4	114	1	0	0	0	0	0	0	0	1	11554	874	31	1		1	PCDHGA2	5	140719540	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	2958298	140719540	40195720	43	34436										
PCDHGB1	56104	broad.mit.edu	37	chr5	140730581	140730581	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gggttagcctccaagaaaacGtaccgtggggaacctccgtg	13	11	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:140730581G>A	uc003ljo.1	+	1	754	c.754G>A	c.(754-756)GTA>ATA	p.V252I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.V252I	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	252	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAGAAAACGTACCGTGGGG	0.522													0	0	0	0.007413	0	17	66										A	140730581	G	A	140730581	3	1	114	1	0	0	0	0	1	0	0	0	11562	1145	40	2	756	2	PCDHGB1	5	140730581	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	11041	140730581	40184679	44	34437										
PCDHGA8	9708	broad.mit.edu	37	chr5	140774130	140774130	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tggcgccccgctccgcagagCgtggctacctggtgaccaag	14	15	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr5:140774130C>T	uc003lkd.1	+	1	2648	c.1750C>T	c.(1750-1752)CGT>TGT	p.R584C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.R584C	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	584	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCGCAGAGCGTGGCTACCT	0.672													0	0	0	0.01441	0	47	146										T	140774130	C	T	140774130	3	4	114	1	0	0	0	0	1	0	0	0	11560	768	27	2	1752	2	PCDHGA8	5	140774130	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	43549	140774130	40141130	45	34438										
KIAA0319	9856	broad.mit.edu	37	chr6	24596319	24596319	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtctccaacagaggagttgaAggccccctcgctgcccggca	12	15	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:24596319A>G	uc011djo.1	-	3	820	c.583T>C	c.(583-585)TTC>CTC	p.F195L	KIAA0319_uc011djp.1_Missense_Mutation_p.F150L|KIAA0319_uc003neh.1_Missense_Mutation_p.F195L|KIAA0319_uc011djq.1_Missense_Mutation_p.F186L|KIAA0319_uc011djr.1_Missense_Mutation_p.F195L	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	195	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						GAGGAGTTGAAGGCCCCCTCG	0.632													0	0	0	0.006122	0	13	23										G	24596319	A	G	24596319	3	3	114	1	0	0	0	0	1	0	0	0	8168	72	3	5	2711	5	KIAA0319	6	24596319	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08		24596319	146518748	46	34439										
HIST1H1E	3008	broad.mit.edu	37	chr6	26156830	26156830	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	agcgctggcagccgctggctAtgacgtggagaagaacaaca	14	10	0	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:26156830A>G	uc003ngq.2	+	1	272	c.212A>G	c.(211-213)TAT>TGT	p.Y71C	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	71	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						GCCGCTGGCTATGACGTGGAG	0.627													0	0	0	0.006122	0	15	30										G	26156830	A	G	26156830	3	3	114	1	0	0	0	0	1	0	0	0	7126	449	16	5	214	5	HIST1H1E	6	26156830	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08	1560511	26156830	144958237	47	34440										
MUC21	394263	broad.mit.edu	37	chr6	30954151	30954151	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccaccatctcagggtccagcGtgacctccaatggggtcagc	11	15	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:30954151G>A	uc003nsh.2	+	2	450	c.199G>A	c.(199-201)GTG>ATG	p.V67M	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	67	Ser-rich.|3.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						AGGGTCCAGCGTGACCTCCAA	0.572													0	0	0	0.01441	0	68	180										A	30954151	G	A	30954151	3	1	114	1	0	0	0	0	1	0	0	0	9977	1145	40	2	205	2	MUC21	6	30954151	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	4797321	30954151	140160916	48	34441										
RNF5	6048	broad.mit.edu	37	chr6	32146400	32146400	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tggagactgctcgggaagctGtggtcagtgtgtgtggccac	17	8	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:32146400G>T	uc003oaj.3	+	1	239	c.112G>T	c.(112-114)GTG>TTG	p.V38L	AGPAT1_uc003oae.2_5'Flank|AGPAT1_uc011dpk.1_5'Flank|AGPAT1_uc003oaf.2_5'Flank|AGPAT1_uc003oag.2_5'Flank|AGPAT1_uc003oah.2_5'Flank|AGPAT1_uc003oai.1_5'Flank|AGPAT1_uc011dpl.1_5'Flank	NM_006913	NP_008844	Q99942	RNF5_HUMAN	ring finger protein 5	38	RING-type.				ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						TCGGGAAGCTGTGGTCAGTGT	0.612													1	0	1.57019e-19	0.007835	1.71387e-19	29	97										T	32146400	G	T	32146400	3	4	114	1	0	0	0	0	1	0	0	0	13497	1377	48	4	114	4	RNF5	6	32146400	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	1192249	32146400	138968667	49	34442										
B3GALT4	8705	broad.mit.edu	37	chr6	33245984	33245984	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccctttccaccctatgcctCaggcacggggtatgtgctgt	10	15	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:33245984C>A	uc003odr.2	+	1	1068	c.788C>A	c.(787-789)TCA>TAA	p.S263*		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	263	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						CCCTATGCCTCAGGCACGGGG	0.637													1	0	2.47511e-08	0.008361	2.66673e-08	30	39										A	33245984	C	A	33245984	4	1	114	1	0	0	0	0	0	1	0	0	1249	838	29	3	790	3	B3GALT4	6	33245984	Nonsense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	1099584	33245984	137869083	50	34443										
LEMD2	221496	broad.mit.edu	37	chr6	33740447	33740447	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gaagagggcttagtccatctCcacaccagcatgtcctctcc	8	15	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:33740447C>G	uc011drm.1	-	9	1483	c.1470G>C	c.(1468-1470)TGG>TGC	p.W490C	LEMD2_uc010jvg.2_Missense_Mutation_p.W199C|LEMD2_uc011drl.1_Missense_Mutation_p.W188C|LEMD2_uc003ofe.2_Missense_Mutation_p.W188C	NM_181336	NP_851853	Q8NC56	LEMD2_HUMAN	LEM domain containing 2 isoform 1	490						integral to nuclear inner membrane				central_nervous_system(1)	1						TAGTCCATCTCCACACCAGCA	0.622													0	0	0	0.027894	0	35	37										G	33740447	C	G	33740447	3	3	114	1	0	0	0	0	1	0	0	0	8720	856	30	1	45	1	LEMD2	6	33740447	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	494463	33740447	137374620	51	34444										
C6orf153	88745	broad.mit.edu	37	chr6	42989434	42989451	+	In_Frame_Del	DEL	CGGGGCCCGACGTCCCCG	CGGGGCCCGACGTCCCCG	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gccggggccggggccggggcCggggcccgacgtccccgcgg					rs60664426		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:42989434_42989451delCGGGGCCCGACGTCCCCG	uc003otp.1	+	1	50_67	c.42_59delCGGGGCCCGACGTCCCCG	c.(40-60)GCCGGGGCCCGACGTCCCCGC>GCC	p.GARRPR15del		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	15_20					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			gggccggggccggggcccgacgtccccgcggggcccgg	0.55																		3	3	---	---								-	42989451	CGGGGCCCGACGTCCCCG	-	42989434	7	5	114	1	0	1	0	1	0	0	0	0	2338	639	23	0	44	0	C6orf153	6	42989434	In_Frame_Del	DEL	CGGGGCCCGACGTCCCCG	TCGA-GV-A3JV-01A-11D-A21Z-08	9248987	42989434	128125633	52	34445										
FAM135A	57579	broad.mit.edu	37	chr6	71234834	71234834	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	taggaccttggacagagcttCgacaagaggaaatacttgtg	12	7	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:71234834C>T	uc003pfj.2	+	13	2180	c.2047C>T	c.(2047-2049)CGA>TGA	p.R683*	FAM135A_uc003pfi.2_Nonsense_Mutation_p.R487*|FAM135A_uc003pfh.2_Nonsense_Mutation_p.R470*|FAM135A_uc003pfl.2_Nonsense_Mutation_p.R350*|FAM135A_uc003pfn.2_Nonsense_Mutation_p.R113*|FAM135A_uc003pfo.1_Nonsense_Mutation_p.R54*	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	683										central_nervous_system(1)	1						GACAGAGCTTCGACAAGAGGA	0.353													0	0	0	0.023175	0	34	42										T	71234834	C	T	71234834	4	4	114	1	0	0	0	0	0	1	0	0	5448	876	31	1	2175	1	FAM135A	6	71234834	Nonsense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	28245400	71234834	99880233	53	34446										
LAMA2	3908	broad.mit.edu	37	chr6	129380937	129380937	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctaactcaatagagagacacCcgattacaaatgctattgat	6	9	1	3	rs140199131		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:129380937C>T	uc003qbn.2	+	3	397	c.292C>T	c.(292-294)CCG>TCG	p.P98S	LAMA2_uc003qbo.2_Missense_Mutation_p.P98S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	98	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGAGAGACACCCGATTACAAA	0.328													0	0	0	0.004482	0	9	44										T	129380937	C	T	129380937	3	4	114	1	0	0	0	0	1	0	0	0	8606	623	22	2	302	2	LAMA2	6	129380937	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	58146103	129380937	41734130	54	34447										
ALDH8A1	64577	broad.mit.edu	37	chr6	135263702	135263702	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttgccagtgctaaggttttcCctgtaagaagcaaacaacat	8	9	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:135263702C>T	uc003qew.2	-	3	340	c.287G>A	c.(286-288)GGG>GAG	p.G96E	ALDH8A1_uc003qex.2_Missense_Mutation_p.G96E|ALDH8A1_uc010kgh.2_5'UTR|ALDH8A1_uc011ecx.1_Missense_Mutation_p.G96E	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	96					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		TAAGGTTTTCCCTGTAAGAAG	0.522													0	0	0	0.007413	0	18	573										T	135263702	C	T	135263702	3	4	114	1	0	0	0	0	1	0	0	0	505	637	22	2	1196	2	ALDH8A1	6	135263702	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	5882765	135263702	35851365	55	34448										
PLEKHG1	57480	broad.mit.edu	37	chr6	151055093	151055093	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccacccagagcgcagtggagAgtggactcaaacggggcacc	14	13	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:151055093A>G	uc003qny.1	+	3	588	c.276A>G	c.(274-276)AGA>AGG	p.R92R	PLEKHG1_uc011eel.1_Silent_p.R132R|PLEKHG1_uc011eem.1_Silent_p.R151R|PLEKHG1_uc003qnz.2_Silent_p.R92R	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	92					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CGCAGTGGAGAGTGGACTCAA	0.602													0	0	0	0.001984	0	5	31										G	151055093	A	G	151055093	2	3	114	1	0	0	0	0	0	0	0	1	12068	301	11	5		5	PLEKHG1	6	151055093	Silent	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08	15791391	151055093	20059974	56	34449										
SERAC1	84947	broad.mit.edu	37	chr6	158564168	158564168	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	acactcatctagctctgtttGaggtaaggaagccagcaact	9	10	3	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:158564168G>A	uc003qrc.2	-	8	800	c.658C>T	c.(658-660)CAA>TAA	p.Q220*	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	220					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		AGCTCTGTTTGAGGTAAGGAA	0.373													0	0	0	0.015359	0	27	52										A	158564168	G	A	158564168	4	1	114	1	0	0	0	0	0	1	0	0	14074	1299	45	1	1346	1	SERAC1	6	158564168	Nonsense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	7509075	158564168	12550899	57	34450										
PARK2	5071	broad.mit.edu	37	chr6	162864342	162864342	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ggccgccaagggagactcacCtgcacagtccagtcattcct	10	15	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr6:162864342C>T	uc003qtx.3	-	2	305	c.171G>A	c.(169-171)CAG>CAA	p.Q57Q	PARK2_uc010kkd.2_5'UTR|PARK2_uc003qtw.3_5'UTR|PARK2_uc003qty.3_Silent_p.Q57Q|PARK2_uc003qtz.3_Silent_p.Q57Q|PARK2_uc010kke.1_Silent_p.Q57Q	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	57	Ubiquitin-like.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GGAGACTCACCTGCACAGTCC	0.567													0	0	0	0.028581	0	15	53										T	162864342	C	T	162864342	2	4	114	1	0	0	0	0	0	0	0	1	11449	695	24	2		2	PARK2	6	162864342	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	4300174	162864342	8250725	58	34451										
THSD7A	221981	broad.mit.edu	37	chr7	11871469	11871470	+	In_Frame_Ins	INS	-	-	GCAGCG													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcgtagcagcagcagcaggaINSgcagcggcagcggcagcggc							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:11871469_11871470insGCAGCG	uc003ssf.3	-	1	355_356	c.103_104insCGCTGC	c.(103-105)CTC>CCGCTGCTC	p.34_35insPL		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	34_35						integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		cagcagcaggagcagcggcagc	0.436										HNSCC(18;0.044)								4	8	---	---								GCAGCG	11871470	-	GCAGCG	11871469	7	5	114	1	0	1	1	0	0	0	0	0	15876	304	11	0	4977	0	THSD7A	7	11871469	In_Frame_Ins	INS	-	TCGA-GV-A3JV-01A-11D-A21Z-08		11871469	147267194	59	34452										
FZD9	8326	broad.mit.edu	37	chr7	72850005	72850005	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcccgggccaaggcctgccgCgcccccgggagctacggacg	16	18	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:72850005C>T	uc003tyb.2	+	1	1897	c.1668C>T	c.(1666-1668)CGC>CGT	p.R556R		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	556	Cytoplasmic (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				AGGCCTGCCGCGCCCCCGGGA	0.652													0	0	0	0.00308	0	7	51										T	72850005	C	T	72850005	2	4	114	1	0	0	0	0	0	0	0	1	6137	755	27	2		2	FZD9	7	72850005	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	60978536	72850005	86288658	60	34453										
CYP3A7	1551	broad.mit.edu	37	chr7	99314836	99314836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcttgcctgtctctgcttccCgcctcagatttctcaccaac	6	17	3	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:99314836C>T	uc003uru.2	-	6	590	c.485G>A	c.(484-486)CGG>CAG	p.R162Q	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	162					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.R162R(1)		ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					CTCTGCTTCCCGCCTCAGATT	0.502													0	0	0	0.025465	0	26	104										T	99314836	C	T	99314836	3	4	114	1	0	0	0	0	1	0	0	0	4181	652	23	2	1058	2	CYP3A7	7	99314836	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	26464831	99314836	59823827	61	34454										
MUC17	140453	broad.mit.edu	37	chr7	100686998	100686998	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccaggacaaaacccagcacaCggaccacttccttccccacg	6	19	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:100686998C>T	uc003uxp.1	+	3	12354	c.12301C>T	c.(12301-12303)CGG>TGG	p.R4101W	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4101	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACCCAGCACACGGACCACTTC	0.562													0	0	0	0.007291	0	28	102										T	100686998	C	T	100686998	3	4	114	1	0	0	0	0	1	0	0	0	9974	527	19	2	12311	2	MUC17	7	100686998	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	1372162	100686998	58451665	62	34455										
AASS	10157	broad.mit.edu	37	chr7	121741434	121741434	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	acaatacttacctgctctccCggagtgtctggatatattta	7	10	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:121741434C>T	uc003vka.2	-	12	1493	c.1397G>A	c.(1396-1398)CGG>CAG	p.R466Q	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.R466Q|AASS_uc011knw.1_5'UTR	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	466					protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCTGCTCTCCCGGAGTGTCTG	0.318													0	0	0	0.014323	0	17	59										T	121741434	C	T	121741434	3	4	114	1	0	0	0	0	1	0	0	0	24	652	23	2	1431	2	AASS	7	121741434	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	21054436	121741434	37397229	63	34456										
ZNF786	136051	broad.mit.edu	37	chr7	148768943	148768943	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cgagcctgcgtgctgtccacTgggagggagcgcttgccgca	16	13	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr7:148768943T>C	uc003wfh.2	-	4	1058	c.921A>G	c.(919-921)CCA>CCG	p.P307P	ZNF786_uc011kuk.1_Silent_p.P270P|ZNF786_uc003wfi.2_Silent_p.P221P	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGCTGTCCACTGGGAGGGAGC	0.697													0	0	0	0.006122	0	15	22										C	148768943	T	C	148768943	2	2	114	1	0	0	0	0	0	0	0	1	18155	1567	55	5		5	ZNF786	7	148768943	Silent	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08	27027509	148768943	10369720	64	34457										
DLC1	10395	broad.mit.edu	37	chr8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccgactggctgctgctgctgCtggtctgcgtggagttggaa	16	10	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:12957624C>G	uc003wwm.2	-	9	2666	c.2222G>C	c.(2221-2223)AGC>ACC	p.S741T	DLC1_uc003wwk.1_Missense_Mutation_p.S304T|DLC1_uc003wwl.1_Missense_Mutation_p.S338T|DLC1_uc011kxx.1_Missense_Mutation_p.S230T	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GCTGCTGCTGCTGGTCTGCGT	0.627													0	0	0	0.009096	0	3	90										G	12957624	C	G	12957624	3	3	114	1	0	0	0	0	1	0	0	0	4550	797	28	4	2404	4	DLC1	8	12957624	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		12957624	133406398	65	34458										
MTMR7	9108	broad.mit.edu	37	chr8	17157445	17157445	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	actcggtgcatgctcaccacCacttggagaccgacagctca	9	15	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:17157445C>T	uc003wxm.2	-	14	2148	c.1909G>A	c.(1909-1911)GGT>AGT	p.G637S	MTMR7_uc011kya.1_Missense_Mutation_p.G271S|MTMR7_uc011kyb.1_Missense_Mutation_p.G228S	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	637							protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		TGCTCACCACCACTTGGAGAC	0.498													0	0	0	0.01441	0	70	66										T	17157445	C	T	17157445	3	4	114	1	0	0	0	0	1	0	0	0	9948	594	21	2	77	2	MTMR7	8	17157445	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	4199821	17157445	129206577	66	34459										
FZD3	7976	broad.mit.edu	37	chr8	28385479	28385479	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tatatccctaaacagagttcGaattgagattccattagaaa	6	7	0	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:28385479G>T	uc003xgx.2	+	5	1680	c.1202G>T	c.(1201-1203)CGA>CTA	p.R401L	FZD3_uc010lvb.2_Missense_Mutation_p.R401L	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	401	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		AACAGAGTTCGAATTGAGATT	0.403													1	0	1.17611e-34	0.01441	1.3094e-34	82	83										T	28385479	G	T	28385479	3	4	114	1	0	0	0	0	1	0	0	0	6131	1058	37	3	1212	3	FZD3	8	28385479	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	11228034	28385479	117978543	67	34460										
FUT10	84750	broad.mit.edu	37	chr8	33247281	33247281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccagtcatgatgggctttccGaggcagaggtaagctatcta	12	9	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:33247281G>A	uc003xje.2	-	4	768	c.412C>T	c.(412-414)CGG>TGG	p.R138W	FUT10_uc003xjc.2_Missense_Mutation_p.R145W|FUT10_uc003xjd.2_Missense_Mutation_p.R110W|FUT10_uc011lbi.1_Missense_Mutation_p.R188W|FUT10_uc003xjf.2_Missense_Mutation_p.R76W|FUT10_uc003xjg.2_Missense_Mutation_p.R110W|FUT10_uc003xjh.2_Missense_Mutation_p.R138W	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	138	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TGGGCTTTCCGAGGCAGAGGT	0.388													0	0	0	0.007835	0	37	71										A	33247281	G	A	33247281	3	1	114	1	0	0	0	0	1	0	0	0	6102	1057	37	1	1035	1	FUT10	8	33247281	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	4861802	33247281	113116741	68	34461										
PXDNL	137902	broad.mit.edu	37	chr8	52384861	52384861	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gctcaaaagtaattcgggggCtctctgcaacaaaagaatta	9	8	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:52384861C>A	uc003xqu.3	-	8	799	c.698G>T	c.(697-699)AGC>ATC	p.S233I		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	233	LRRCT.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AATTCGGGGGCTCTCTGCAAC	0.408													1	0	8.34094e-07	0.008871	8.70585e-07	17	133										A	52384861	C	A	52384861	3	1	114	1	0	0	0	0	1	0	0	0	12848	797	28	4	3757	4	PXDNL	8	52384861	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	19137580	52384861	93979161	69	34462										
VPS13B	157680	broad.mit.edu	37	chr8	100865842	100865842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctggtcccctccctggggaaGagcctgtggctgcgttgttt	14	12	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:100865842G>A	uc003yiv.2	+	56	10411	c.10300G>A	c.(10300-10302)GAG>AAG	p.E3434K	VPS13B_uc003yiw.2_Missense_Mutation_p.E3409K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3434					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCCTGGGGAAGAGCCTGTGGC	0.527													0	0	0	0.01441	0	45	58										A	100865842	G	A	100865842	3	1	114	1	0	0	0	0	1	0	0	0	17187	943	33	1	10712	1	VPS13B	8	100865842	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	48480981	100865842	45498180	70	34463										
PKHD1L1	93035	broad.mit.edu	37	chr8	110498987	110498987	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aagattaccccggttggtctGaggactcttttggagcacgc	12	10	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:110498987G>A	uc003yne.2	+	59	9921	c.9817G>A	c.(9817-9819)GAG>AAG	p.E3273K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3273	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CGGTTGGTCTGAGGACTCTTT	0.423										HNSCC(38;0.096)			0	0	0	0.01441	0	59	336										A	110498987	G	A	110498987	3	1	114	1	0	0	0	0	1	0	0	0	11972	1291	45	1	10051	1	PKHD1L1	8	110498987	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	9633145	110498987	35865035	71	34464										
CSMD3	114788	broad.mit.edu	37	chr8	113694839	113694839	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgcattgattggtattccagGatcagggcattcattatgtc	10	7	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:113694839G>A	uc003ynu.2	-	16	2668	c.2509C>T	c.(2509-2511)CCT>TCT	p.P837S	CSMD3_uc003yns.2_Missense_Mutation_p.P109S|CSMD3_uc003ynt.2_Missense_Mutation_p.P797S|CSMD3_uc011lhx.1_Missense_Mutation_p.P733S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	837	Sushi 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGTATTCCAGGATCAGGGCAT	0.358										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.007413	0	15	164										A	113694839	G	A	113694839	3	1	114	1	0	0	0	0	1	0	0	0	3946	1174	41	1	8838	1	CSMD3	8	113694839	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	3195852	113694839	32669183	72	34465										
C8orf85	441376	broad.mit.edu	37	chr8	117950663	117950663	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cgctgctggaggacctcagaCgacggctgacgcgcgccttc	14	15	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:117950663C>T	uc003yof.2	+	1	200	c.181C>T	c.(181-183)CGA>TGA	p.R61*		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing	61	Ala/Arg-rich.										0						GGACCTCAGACGACGGCTGAC	0.607													0	0	0	0.014758	0	4	35										T	117950663	C	T	117950663	4	4	114	1	0	0	0	0	0	1	0	0	2441	528	19	2	183	2	C8orf85	8	117950663	Nonsense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	4255824	117950663	28413359	73	34466										
FER1L6	654463	broad.mit.edu	37	chr8	125082841	125082841	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	agtcataggaaaatttaaggCaggttccatttttaatcctt	7	6	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:125082841C>T	uc003yqw.2	+	30	4172	c.3966_splice	c.e30+2	p.K1322_splice	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6							integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AAATTTAAGGCAGGTTCCATT	0.418													0	0	0	0.027894	0	33	109										T	125082841	C	T	125082841	5	4	114	1	0	0	0	0	0	0	1	0	5815	724	25	2	4082	2	FER1L6	8	125082841	Splice_Site	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	7132178	125082841	21281181	74	34467										
FLJ43860	389690	broad.mit.edu	37	chr8	142481169	142481169	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aactcacttttgtggcacatCaagagctggtagagatggct	11	8	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr8:142481169C>G	uc003ywi.2	-	16	2073	c.1992G>C	c.(1990-1992)TTG>TTC	p.L664F	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	664							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGTGGCACATCAAGAGCTGGT	0.592													0	0	0	0.01441	0	77	338										G	142481169	C	G	142481169	3	3	114	1	0	0	0	0	1	0	0	0	5930	825	29	1	2024	1	FLJ43860	8	142481169	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	17398328	142481169	3882853	75	34468										
C9orf46	55848	broad.mit.edu	37	chr9	5431965	5431965	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttcattcatagattttgaaaAtataaaccccattttgacct	3	8	2	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:5431965A>T	uc003zjc.2	-	3	217	c.13T>A	c.(13-15)TTT>ATT	p.F5I	C9orf46_uc003zjd.2_Missense_Mutation_p.F5I	NM_018465	NP_060935	Q9HBL7	CI046_HUMAN	hypothetical protein LOC55848	5						integral to membrane				ovary(1)	1	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.00106)|Lung(218;0.125)		GATTTTGAAAATATAAACCCC	0.313													0	0	0	0.021553	0	5	5										T	5431965	A	T	5431965	3	4	114	1	0	0	0	0	1	0	0	0	2484	101	4	5	446	5	C9orf46	9	5431965	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08		5431965	135781466	76	34469										
RUSC2	9853	broad.mit.edu	37	chr9	35547012	35547012	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atgggggacaacacgcagtcGggctggagtggtggaagggc	20	7	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:35547012G>A	uc003zww.2	+	2	749	c.494G>A	c.(493-495)CGG>CAG	p.R165Q	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.R165Q	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	165						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			ACACGCAGTCGGGCTGGAGTG	0.622													0	0	0	0.016522	0	22	69										A	35547012	G	A	35547012	3	1	114	1	0	0	0	0	1	0	0	0	13751	1116	39	2	496	2	RUSC2	9	35547012	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	30115047	35547012	105666419	77	34470										
NOL8	55035	broad.mit.edu	37	chr9	95081520	95081520	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	caccttatgccctggcacttCtgtccctggcacagctttca	7	16	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:95081520C>T	uc004arv.2	-	5	737	c.400G>A	c.(400-402)GAA>AAA	p.E134K	NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.E66K|NOL8_uc004arx.2_Missense_Mutation_p.E134K	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	134					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						CCTGGCACTTCTGTCCCTGGC	0.463													0	0	0	0.016723	0	12	30										T	95081520	C	T	95081520	3	4	114	1	0	0	0	0	1	0	0	0	10527	922	32	1	3155	1	NOL8	9	95081520	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	59534508	95081520	46131911	78	34471										
NOTCH1	4851	broad.mit.edu	37	chr9	139399897	139399897	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgcagttcttccaggggtcaTtgaagttgagggagcagtca	14	7	3	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr9:139399897T>A	uc004chz.2	-	25	4451	c.4451A>T	c.(4450-4452)AAT>ATT	p.N1484I	NOTCH1_uc004cia.1_Missense_Mutation_p.N714I	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1484	Extracellular (Potential).|LNR 1.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCAGGGGTCATTGAAGTTGAG	0.622			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.020292	0	9	36										A	139399897	T	A	139399897	3	1	114	1	0	0	0	0	1	0	0	0	10547	1493	52	5	3256	5	NOTCH1	9	139399897	Missense_Mutation	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08	44318377	139399897	1813534	79	34472										
C10orf2	56652	broad.mit.edu	37	chr10	102749592	102749592	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atcactgggctgaccgctttGaggacctgcccctctatttc	9	14	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr10:102749592G>C	uc001ksf.2	+	2	2110	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Missense_Mutation_p.E479Q|C10orf2_uc001ksi.2_Missense_Mutation_p.E25Q|C10orf2_uc010qpv.1_Missense_Mutation_p.E25Q|C10orf2_uc001ksh.2_RNA	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	479	SF4 helicase.		E -> K (in PEOA3).		cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TGACCGCTTTGAGGACCTGCC	0.532													0	0	0	0.01441	0	45	144										C	102749592	G	C	102749592	3	2	114	1	0	0	0	0	1	0	0	0	1597	1291	45	1	1441	1	C10orf2	10	102749592	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		102749592	32785155	80	34473										
SFXN4	119559	broad.mit.edu	37	chr10	120925084	120925084	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccagaagcgcacgttgggctCaatgaaggcggggacggcgt	17	10	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr10:120925084C>A	uc001leb.2	-	1	121	c.76G>T	c.(76-78)GAG>TAG	p.E26*	SFXN4_uc001ldz.2_5'Flank|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	26					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		ACGTTGGGCTCAATGAAGGCG	0.433													1	0	4.3838e-07	0.016723	4.60437e-07	12	26										A	120925084	C	A	120925084	4	1	114	1	0	0	0	0	0	1	0	0	14197	835	29	3	993	3	SFXN4	10	120925084	Nonsense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	18175492	120925084	14609663	81	34474										
CDHR5	53841	broad.mit.edu	37	chr11	617954	617954	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttctccatcctgggcctcacCggagctttgccacagcagca	9	16	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:617954C>T	uc001lqj.2	-	14	2223	c.2118G>A	c.(2116-2118)CCG>CCA	p.P706P	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Silent_p.P512P|CDHR5_uc009ycc.2_Silent_p.P540P|CDHR5_uc009ycd.2_Silent_p.P700P|CDHR5_uc001lql.2_Silent_p.P706P	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	706	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						TGGGCCTCACCGGAGCTTTGC	0.672													0	0	0	0.010729	0	9	12										T	617954	C	T	617954	2	4	114	1	0	0	0	0	0	0	0	1	3122	666	23	2		2	CDHR5	11	617954	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		617954	134388562	82	34475										
MRGPRE	116534	broad.mit.edu	37	chr11	3249921	3249921	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccattccccagcagcccacCgaggccgagcccctcggtga	10	20	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:3249921C>T	uc001lxq.3	-	2	416	c.106G>A	c.(106-108)GGT>AGT	p.G36S		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	36	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCAGCCCACCGAGGCCGAGC	0.652													0	0	0	0.006214	0	9	76										T	3249921	C	T	3249921	3	4	114	1	0	0	0	0	1	0	0	0	9764	652	23	2	833	2	MRGPRE	11	3249921	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	2631967	3249921	131756595	83	34476										
C11orf16	56673	broad.mit.edu	37	chr11	8947502	8947502	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	agagcagcaaggggcccagtGaaggggcctggggtgctccc	18	11	0	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:8947502G>A	uc001mhb.3	-	5	836	c.712C>T	c.(712-714)CAC>TAC	p.H238Y	C11orf16_uc001mhc.3_Missense_Mutation_p.H238Y	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	238										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GGGGCCCAGTGAAGGGGCCTG	0.607													0	0	0	0.013537	0	10	88										A	8947502	G	A	8947502	3	1	114	1	0	0	0	0	1	0	0	0	1631	1290	45	1	699	1	C11orf16	11	8947502	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	5697581	8947502	126059014	84	34477										
TIGD3	220359	broad.mit.edu	37	chr11	65123927	65123927	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cgggtactgctgggtgggctCcaggctgccccgagatgctt	16	12	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:65123927C>T	uc001odo.3	+	2	811	c.648C>T	c.(646-648)CTC>CTT	p.L216L		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	216	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						TGGGTGGGCTCCAGGCTGCCC	0.637													0	0	0	0.00308	0	8	129										T	65123927	C	T	65123927	2	4	114	1	0	0	0	0	0	0	0	1	15894	842	30	1		1	TIGD3	11	65123927	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	56176425	65123927	69882589	85	34478										
SSH3	54961	broad.mit.edu	37	chr11	67077777	67077777	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctggagccctccttggagctGgagagcacctcagagaccag	13	13	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:67077777G>A	uc001okj.2	+	13	1828	c.1650G>A	c.(1648-1650)CTG>CTA	p.L550L	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Silent_p.L404L	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	550					regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCTTGGAGCTGGAGAGCACCT	0.622													0	0	0	0.028581	0	12	72										A	67077777	G	A	67077777	2	1	114	1	0	0	0	0	0	0	0	1	15185	1335	47	2		2	SSH3	11	67077777	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	1953850	67077777	67928739	86	34479										
PRCP	5547	broad.mit.edu	37	chr11	82611320	82611320	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aatagttcttggctacagccGggagggatgtggggttggtt	17	5	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:82611320G>C	uc001ozs.2	-	1	238	c.125C>G	c.(124-126)CCG>CGG	p.P42R	PRCP_uc001ozr.2_Missense_Mutation_p.P42R|C11orf82_uc001ozt.2_5'Flank|C11orf82_uc010rsr.1_5'Flank|C11orf82_uc010rss.1_5'Flank|C11orf82_uc009yvd.2_5'Flank	NM_005040	NP_005031	P42785	PCP_HUMAN	prolylcarboxypeptidase isoform 1 preproprotein	42					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			skin(1)	1						GGCTACAGCCGGGAGGGATGT	0.637													0	0	0	0.028581	0	13	85										C	82611320	G	C	82611320	3	2	114	1	0	0	0	0	1	0	0	0	12449	1116	39	4	1468	4	PRCP	11	82611320	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	15533543	82611320	52395196	87	34480										
KBTBD3	143879	broad.mit.edu	37	chr11	105929784	105929784	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gaattccattacatgtgcttCgttgattgaaagcatatgaa	8	6	0	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:105929784C>T	uc001pja.2	-	3	681	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	KBTBD3_uc001pjb.2_Missense_Mutation_p.R14Q|KBTBD3_uc009yxm.2_Intron	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	10										ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		ACATGTGCTTCGTTGATTGAA	0.328													0	0	0	0.014758	0	4	35										T	105929784	C	T	105929784	3	4	114	1	0	0	0	0	1	0	0	0	7994	884	31	1	1805	1	KBTBD3	11	105929784	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	23318464	105929784	29076732	88	34481										
CHEK1	1111	broad.mit.edu	37	chr11	125513987	125513987	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttctgtcttaatgcctcagtGaagaaaatgtgaagtactcc	8	8	3	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr11:125513987G>A	uc009zbo.2	+	10	1817	c.925G>A	c.(925-927)GAA>AAA	p.E309K	CHEK1_uc010sbh.1_Missense_Mutation_p.E325K|CHEK1_uc010sbi.1_Missense_Mutation_p.E309K|CHEK1_uc001qcf.3_Missense_Mutation_p.E309K|CHEK1_uc009zbp.2_Missense_Mutation_p.E309K|CHEK1_uc001qcg.3_Missense_Mutation_p.E309K|CHEK1_uc009zbq.2_Missense_Mutation_p.E309K|CHEK1_uc001qci.1_RNA|CHEK1_uc001qcj.2_5'UTR	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	309					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		ATGCCTCAGTGAAGAAAATGT	0.378								Other_conserved_DNA_damage_response_genes					0	0	0	0.007835	0	38	26										A	125513987	G	A	125513987	3	1	114	1	0	0	0	0	1	0	0	0	3334	1304	45	1	959	1	CHEK1	11	125513987	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	19584203	125513987	9492529	89	34482										
VWF	7450	broad.mit.edu	37	chr12	6105241	6105241	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atttcatgcagccctgccttGctccagggctgcaggcacca	10	15	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:6105241G>C	uc001qnn.1	-	35	6240	c.5990C>G	c.(5989-5991)GCA>GGA	p.A1997G	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1997	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GCCCTGCCTTGCTCCAGGGCT	0.522													0	0	0	0.00499	0	14	24										C	6105241	G	C	6105241	3	2	114	1	0	0	0	0	1	0	0	0	17243	1319	46	4	2523	4	VWF	12	6105241	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		6105241	127746654	90	34483										
PRR4	11272	broad.mit.edu	37	chr12	11000981	11000981	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgggatttacctggtatggtGaaagtaaagtcttcatagtt	11	4	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:11000981G>A	uc001qyz.3	-	2	129	c.90C>T	c.(88-90)TTC>TTT	p.F30F	PRR4_uc009zhp.2_Silent_p.F43F|PRH1_uc001qzb.3_RNA|PRR4_uc001qza.3_RNA|PRR4_uc009zhq.1_RNA	NM_007244	NP_009175	Q16378	PROL4_HUMAN	proline rich 4 (lacrimal) isoform 2	30					visual perception	extracellular space					0						CTGGTATGGTGAAAGTAAAGT	0.358													0	0	0	0.007413	0	15	15										A	11000981	G	A	11000981	2	1	114	1	0	0	0	0	0	0	0	1	12599	1281	45	1		1	PRR4	12	11000981	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	4895740	11000981	122850914	91	34484										
ATF7IP	55729	broad.mit.edu	37	chr12	14577646	14577646	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atcctctagtgaactggcctCtgatgatctggccactggtg	11	11	3	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:14577646C>T	uc001rbw.2	+	2	955	c.797C>T	c.(796-798)TCT>TTT	p.S266F	ATF7IP_uc010shs.1_Missense_Mutation_p.S266F|ATF7IP_uc001rbu.2_Missense_Mutation_p.S266F|ATF7IP_uc001rbv.1_Missense_Mutation_p.S266F|ATF7IP_uc001rbx.2_Missense_Mutation_p.S266F|ATF7IP_uc010sht.1_Missense_Mutation_p.S266F|ATF7IP_uc001rby.3_Missense_Mutation_p.S266F|ATF7IP_uc001rbz.1_Missense_Mutation_p.S266F|ATF7IP_uc001rca.2_Missense_Mutation_p.S266F|ATF7IP_uc001rcb.2_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	266					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						GAACTGGCCTCTGATGATCTG	0.483													0	0	0	0.010818	0	29	86										T	14577646	C	T	14577646	3	4	114	1	0	0	0	0	1	0	0	0	1087	913	32	1	799	1	ATF7IP	12	14577646	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	3576665	14577646	119274249	92	34485										
PRPF40B	25766	broad.mit.edu	37	chr12	50026812	50026812	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccagagggccctatggagtGagcatgtggccccagatggg	16	11	0	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:50026812G>A	uc001rur.1	+	6	362	c.298G>A	c.(298-300)GAG>AAG	p.E100K	PRPF40B_uc001rup.1_Missense_Mutation_p.E122K|PRPF40B_uc001ruq.1_Missense_Mutation_p.E94K|PRPF40B_uc001rus.1_Missense_Mutation_p.E43K	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	100	WW 1.				mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CCTATGGAGTGAGCATGTGGC	0.582													0	0	0	0.014758	0	4	10										A	50026812	G	A	50026812	3	1	114	1	0	0	0	0	1	0	0	0	12572	1291	45	1	320	1	PRPF40B	12	50026812	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	35449166	50026812	83825083	93	34486										
KRT7	3855	broad.mit.edu	37	chr12	52627328	52627328	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcggctggacgccgacccctCcctccagcgggtgcgccagg	15	18	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:52627328C>G	uc001saa.1	+	1	375	c.248C>G	c.(247-249)TCC>TGC	p.S83C	KRT7_uc009zmf.1_Missense_Mutation_p.S83C	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	83	Head.			SL -> FS (in Ref. 3; CAB41416).	cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GCCGACCCCTCCCTCCAGCGG	0.677													0	0	0	0.00499	0	16	64										G	52627328	C	G	52627328	3	3	114	1	0	0	0	0	1	0	0	0	8483	855	30	1	250	1	KRT7	12	52627328	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	2600516	52627328	81224567	94	34487										
NAV3	89795	broad.mit.edu	37	chr12	78360077	78360077	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aatgttcaaggtctatctgcTgaaggtaagaaaaagaatga	10	4	3	4			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:78360077T>C	uc001syp.2	+	4	656	c.483T>C	c.(481-483)GCT>GCC	p.A161A	NAV3_uc001syo.2_Silent_p.A161A	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	161	CH.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GTCTATCTGCTGAAGGTAAGA	0.338										HNSCC(70;0.22)			0	0	0	0.010504	0	18	22										C	78360077	T	C	78360077	2	2	114	1	0	0	0	0	0	0	0	1	10185	1567	55	5		5	NAV3	12	78360077	Silent	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08	25732749	78360077	55491818	95	34488										
NTS	4922	broad.mit.edu	37	chr12	86272345	86272345	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcagggcttttcaacactggGaggtatagcaataacaaaat	10	7	1	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:86272345G>A	uc001tag.2	+	3	465	c.358G>A	c.(358-360)GAG>AAG	p.E120K		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	120					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						TCAACACTGGGAGGTATAGCA	0.333													0	0	0	0.00308	0	6	41										A	86272345	G	A	86272345	3	1	114	1	0	0	0	0	1	0	0	0	10709	1175	41	1	368	1	NTS	12	86272345	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	7912268	86272345	47579550	96	34489										
GPR109A	338442	broad.mit.edu	37	chr12	123186957	123186957	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gctggagaagtagtacaccaCggggtccagcatgctgttca	13	10	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr12:123186957C>T	uc001ucx.1	-	1	948	c.874G>A	c.(874-876)GTG>ATG	p.V292M	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	292	Helical; Name=7; (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	TAGTACACCACGGGGTCCAGC	0.527													0	0	0	0.021553	0	4	44										T	123186957	C	T	123186957	3	4	114	1	0	0	0	0	1	0	0	0	6625	536	19	2	221	2	GPR109A	12	123186957	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	36914612	123186957	10664938	97	34490										
KL	9365	broad.mit.edu	37	chr13	33635874	33635874	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	catgctgaggacgaccagctGagggtgtattatatgcagaa	13	7	0	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr13:33635874G>A	uc001uus.2	+	4	2666	c.2658G>A	c.(2656-2658)CTG>CTA	p.L886L	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	886	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		ACGACCAGCTGAGGGTGTATT	0.488													0	0	0	0.007413	0	18	67										A	33635874	G	A	33635874	2	1	114	1	0	0	0	0	0	0	0	1	8331	1277	45	1		1	KL	13	33635874	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		33635874	81534004	98	34491										
POU4F1	5457	broad.mit.edu	37	chr13	79175873	79175873	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtgcgagagcgtgagcgactCgaacctgcagatggtgctct	15	10	1	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr13:79175873C>T	uc001vkv.2	-	2	1171	c.937G>A	c.(937-939)GAG>AAG	p.E313K	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	313	POU-specific.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GTGAGCGACTCGAACCTGCAG	0.647													0	0	0	0.008291	0	6	18										T	79175873	C	T	79175873	3	4	114	1	0	0	0	0	1	0	0	0	12278	893	31	1	326	1	POU4F1	13	79175873	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	45539999	79175873	35994005	99	34492										
TPP2	7174	broad.mit.edu	37	chr13	103326724	103326724	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttcttcacacccaggctcaaGacggagccatttccactgat	7	14	3	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr13:103326724G>A	uc001vpi.3	+	27	3527	c.3424G>A	c.(3424-3426)GAC>AAC	p.D1142N		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	1142					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CCAGGCTCAAGACGGAGCCAT	0.478													0	0	0	0.027356	0	24	39										A	103326724	G	A	103326724	3	1	114	1	0	0	0	0	1	0	0	0	16409	942	33	1	3530	1	TPP2	13	103326724	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	24150851	103326724	11843154	100	34493										
SLC7A7	9056	broad.mit.edu	37	chr14	23249162	23249162	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aagtctaacaatgcctgcaaCgatgaccgcgatcagtgcca	9	12	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:23249162C>T	uc001wgr.3	-	3	736	c.598G>A	c.(598-600)GTT>ATT	p.V200I	SLC7A7_uc001wgs.3_Missense_Mutation_p.V200I|SLC7A7_uc001wgt.3_Missense_Mutation_p.V200I|SLC7A7_uc001wgu.3_Missense_Mutation_p.V200I|SLC7A7_uc001wgv.3_Missense_Mutation_p.V200I	NM_003982	NP_003973	Q9UM01	YLAT1_HUMAN	solute carrier family 7 member 7	200	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			ovary(1)|breast(1)	2	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		ATGCCTGCAACGATGACCGCG	0.299													0	0	0	0.016522	0	18	53										T	23249162	C	T	23249162	3	4	114	1	0	0	0	0	1	0	0	0	14703	536	19	2	969	2	SLC7A7	14	23249162	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		23249162	84100378	101	34494										
MYH6	4624	broad.mit.edu	37	chr14	23866174	23866174	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gggcaccctcatacccacctCtgccggaagtccccgtagag	10	17	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:23866174C>A	uc001wjv.2	-	18	2233	c.2166G>T	c.(2164-2166)CAG>CAT	p.Q722H		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	722	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ATACCCACCTCTGCCGGAAGT	0.627													1	0	8.88839e-20	0.010818	9.76554e-20	22	60										A	23866174	C	A	23866174	3	1	114	1	0	0	0	0	1	0	0	0	10038	912	32	3	3741	3	MYH6	14	23866174	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	617012	23866174	83483366	102	34495										
DDX24	57062	broad.mit.edu	37	chr14	94527268	94527268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccatctattacctgagctgcCgaaggttcctcaaatgataa	7	11	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:94527268C>T	uc001ycj.2	-	4	1487	c.1388G>A	c.(1387-1389)CGG>CAG	p.R463Q	DDX24_uc010twq.1_Missense_Mutation_p.R420Q|DDX24_uc010twr.1_Missense_Mutation_p.R213Q	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	463	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CCTGAGCTGCCGAAGGTTCCT	0.488													0	0	0	0.004482	0	7	34										T	94527268	C	T	94527268	3	4	114	1	0	0	0	0	1	0	0	0	4351	652	23	2	1215	2	DDX24	14	94527268	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	70661094	94527268	12822272	103	34496										
CLMN	79789	broad.mit.edu	37	chr14	95688091	95688091	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaccgaaaaatacgatgcgaCgaggatttgtattcgtgcag	11	7	0	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:95688091C>T	uc001yef.2	-	4	377	c.261G>A	c.(259-261)TCG>TCA	p.S87S		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	87	Actin-binding.|CH 1.					integral to membrane	actin binding				0				Epithelial(152;0.193)		TACGATGCGACGAGGATTTGT	0.443													0	0	0	0.006214	0	8	43										T	95688091	C	T	95688091	2	4	114	1	0	0	0	0	0	0	0	1	3542	523	19	2		2	CLMN	14	95688091	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	1160823	95688091	11661449	104	34497										
PAPOLA	10914	broad.mit.edu	37	chr14	97003321	97003321	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tttttaatttaggtcttgctAtcacagatgaaattttgctg	7	5	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:97003321A>G	uc001yfq.2	+	12	1249	c.1039A>G	c.(1039-1041)ATC>GTC	p.I347V	PAPOLA_uc001yfr.2_Missense_Mutation_p.I347V|PAPOLA_uc010twv.1_Missense_Mutation_p.I347V|PAPOLA_uc010avp.2_Missense_Mutation_p.I97V	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	347					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AGGTCTTGCTATCACAGATGA	0.308													0	0	0	0.016723	0	10	24										G	97003321	A	G	97003321	3	3	114	1	0	0	0	0	1	0	0	0	11429	449	16	5	1085	5	PAPOLA	14	97003321	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08	1315230	97003321	10346219	105	34498										
HSP90AA1	3320	broad.mit.edu	37	chr14	102549453	102549453	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ttttctcttcctgcttctttTtctcttcttcatcctctgga	3	13	6	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr14:102549453T>C	uc001yku.3	-	9	1863	c.1673A>G	c.(1672-1674)AAA>AGA	p.K558R	HSP90AA1_uc001ykv.3_Missense_Mutation_p.K680R|HSP90AA1_uc001ykw.1_Missense_Mutation_p.K379R|HSP90AA1_uc001ykx.1_Missense_Mutation_p.K547R	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	558					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	ctgcttctttttctcttcttc	0.224													0	0	0	0.004482	0	9	15										C	102549453	T	C	102549453	3	2	114	1	0	0	0	0	1	0	0	0	7401	1841	64	5	537	5	HSP90AA1	14	102549453	Missense_Mutation	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08	5546132	102549453	4800087	106	34499										
ATP10A	57194	broad.mit.edu	37	chr15	25947187	25947187	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaatctgcaggcccgcttgaCgcaatttagaaatagtttca	8	9	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:25947187C>T	uc010ayu.2	-	13	2742	c.2636G>A	c.(2635-2637)CGT>CAT	p.R879H		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	879	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GCCCGCTTGACGCAATTTAGA	0.527													0	0	0	0.016522	0	22	76										T	25947187	C	T	25947187	3	4	114	1	0	0	0	0	1	0	0	0	1116	536	19	2	1899	2	ATP10A	15	25947187	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		25947187	76584205	107	34500										
SLC12A1	6557	broad.mit.edu	37	chr15	48541868	48541868	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccatgcctcttatgccaaatCtccaggtaagctgacttcca	6	14	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:48541868C>A	uc001zwn.3	+	14	1997	c.1781C>A	c.(1780-1782)TCT>TAT	p.S594Y	SLC12A1_uc010uew.1_Missense_Mutation_p.S400Y|SLC12A1_uc010bem.2_Missense_Mutation_p.S594Y|SLC12A1_uc001zwq.3_Missense_Mutation_p.S365Y|SLC12A1_uc001zwr.3_Missense_Mutation_p.S321Y	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	594	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TATGCCAAATCTCCAGGTAAG	0.388													1	0	1.08611e-07	0.010729	1.16269e-07	10	48										A	48541868	C	A	48541868	3	1	114	1	0	0	0	0	1	0	0	0	14382	913	32	3	1931	3	SLC12A1	15	48541868	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	22594681	48541868	53989524	108	34501										
CGNL1	84952	broad.mit.edu	37	chr15	57730261	57730261	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atggggtccatctgagactcGcaagtgatgatacccaaaaa	10	9	1	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:57730261G>A	uc002aeg.2	+	2	140	c.64G>A	c.(64-66)GCA>ACA	p.A22T	CGNL1_uc010bfw.2_Missense_Mutation_p.A22T	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	22	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TCTGAGACTCGCAAGTGATGA	0.493													0	0	0	0.01441	0	70	179										A	57730261	G	A	57730261	3	1	114	1	0	0	0	0	1	0	0	0	3304	1087	38	2	66	2	CGNL1	15	57730261	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	9188393	57730261	44801131	109	34502										
DPP8	54878	broad.mit.edu	37	chr15	65756226	65756226	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aagagaaaatttctggaggaGtatagtcaggaagaggacct	13	4	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:65756226G>A	uc002aov.2	-	15	3470	c.1892C>T	c.(1891-1893)ACT>ATT	p.T631I	DPP8_uc002aow.2_Missense_Mutation_p.T631I|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Missense_Mutation_p.T615I|DPP8_uc002aoy.2_Missense_Mutation_p.T631I|DPP8_uc002aoz.2_Missense_Mutation_p.T615I|DPP8_uc010bhj.2_Missense_Mutation_p.T631I|DPP8_uc002apa.2_Missense_Mutation_p.T528I|DPP8_uc010bhi.2_5'UTR|DPP8_uc010bhk.1_Missense_Mutation_p.T200I	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	631					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						TTCTGGAGGAGTATAGTCAGG	0.378													0	0	0	0.007413	0	17	26										A	65756226	G	A	65756226	3	1	114	1	0	0	0	0	1	0	0	0	4732	1029	36	2	828	2	DPP8	15	65756226	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	8025965	65756226	36775166	110	34503										
PTPN9	5780	broad.mit.edu	37	chr15	75762295	75762295	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ggaagggacaccatagtctgGccagctcaagaactggaagt	13	9	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:75762295G>T	uc002bal.2	-	12	1913	c.1405C>A	c.(1405-1407)CCA>ACA	p.P469T		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	469	Tyrosine-protein phosphatase.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						CCATAGTCTGGCCAGCTCAAG	0.507													1	0	5.01169e-05	0.00499	5.16638e-05	15	48										T	75762295	G	T	75762295	3	4	114	1	0	0	0	0	1	0	0	0	12794	1203	42	4	384	4	PTPN9	15	75762295	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	10006069	75762295	26769097	111	34504										
IREB2	3658	broad.mit.edu	37	chr15	78790398	78790398	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	agcactggaaaagtattcagCgtgattgcttcgtttgaaga	11	6	1	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:78790398C>T	uc002bdr.2	+	22	2967	c.2805C>T	c.(2803-2805)AGC>AGT	p.S935S	IREB2_uc010unb.1_Silent_p.S685S	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	935							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AAGTATTCAGCGTGATTGCTT	0.363													0	0	0	0.014758	0	5	53										T	78790398	C	T	78790398	2	4	114	1	0	0	0	0	0	0	0	1	7826	767	27	2		2	IREB2	15	78790398	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	3028103	78790398	23740994	112	34505										
ADAMTS7	11173	broad.mit.edu	37	chr15	79060507	79060507	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ggctgctcgctgcacttcctCtgttggtcatcaggccggcc	12	15	3	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr15:79060507C>A	uc002bej.3	-	17	2824	c.2613G>T	c.(2611-2613)CAG>CAT	p.Q871H	ADAMTS7_uc010und.1_Missense_Mutation_p.Q447H	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	871	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						TGCACTTCCTCTGTTGGTCAT	0.453													1	0	5.18039e-06	0.00308	5.37345e-06	7	18										A	79060507	C	A	79060507	3	1	114	1	0	0	0	0	1	0	0	0	271	912	32	3	2479	3	ADAMTS7	15	79060507	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	270109	79060507	23470885	113	34506										
CCDC78	124093	broad.mit.edu	37	chr16	775266	775266	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cagcctgtgctgctcattctCggggttcatggtgttcttgg	13	10	4	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr16:775266C>T	uc002cjg.2	-	5	569	c.463G>A	c.(463-465)GAG>AAG	p.E155K	CCDC78_uc002cjf.2_Missense_Mutation_p.E4K|CCDC78_uc002cji.3_Missense_Mutation_p.E229K|CCDC78_uc002cjj.3_Missense_Mutation_p.E99K|CCDC78_uc002cjh.2_5'UTR|CCDC78_uc010uuo.1_Missense_Mutation_p.E155K|CCDC78_uc002cjk.2_Missense_Mutation_p.E144K|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	155										central_nervous_system(1)	1		Hepatocellular(780;0.0218)				TGCTCATTCTCGGGGTTCATG	0.627													0	0	0	0.010818	0	22	108										T	775266	C	T	775266	3	4	114	1	0	0	0	0	1	0	0	0	2852	893	31	1	893	1	CCDC78	16	775266	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		775266	89579487	114	34507										
SRRM2	23524	broad.mit.edu	37	chr16	2818182	2818182	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcttcatcatcgtcgtcgtcGtcctcctcctcctctggctc	6	18	4	0	rs149616150	byFrequency	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr16:2818182G>C	uc002crk.2	+	11	8202	c.7653G>C	c.(7651-7653)TCG>TCC	p.S2551S	SRRM2_uc002crj.1_Silent_p.S2455S|SRRM2_uc002crl.1_Silent_p.S2551S|SRRM2_uc010bsu.1_Silent_p.S2455S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2551	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						cgtcgtcgtcgtcctcctcct	0.368													0	0	0	0.013537	0	11	10										C	2818182	G	C	2818182	2	2	114	1	0	0	0	0	0	0	0	1	15168	1132	40	4		4	SRRM2	16	2818182	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	2042916	2818182	87536571	115	34508										
CREBBP	1387	broad.mit.edu	37	chr16	3779153	3779153	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aggtgctgctgctgctgggcCtcacgctcgatctgccgagc	14	14	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr16:3779153C>T	uc002cvv.2	-	31	6099	c.5895G>A	c.(5893-5895)GAG>GAA	p.E1965E	CREBBP_uc002cvw.2_Silent_p.E1927E	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1965					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCTGCTGGGCCTCACGCTCGA	0.711			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.004672	0	3	6										T	3779153	C	T	3779153	2	4	114	1	0	0	0	0	0	0	0	1	3861	680	24	2		2	CREBBP	16	3779153	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	960971	3779153	86575600	116	34509										
ABR	29	broad.mit.edu	37	chr17	1028677	1028677	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcctcattcccctctccgtcGtactcgtccgtcccgtagct	6	19	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:1028677G>A	uc002fsd.2	-	2	197	c.87C>T	c.(85-87)TAC>TAT	p.Y29Y	ABR_uc002fse.2_Translation_Start_Site|ABR_uc010cjq.1_Silent_p.Y41Y	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	29					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		CCTCTCCGTCGTACTCGTCCG	0.592													0	0	0	0.01441	0	44	142										A	1028677	G	A	1028677	2	1	114	1	0	0	0	0	0	0	0	1	99	1140	40	2		2	ABR	17	1028677	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		1028677	80166533	117	34510										
CYTSB	92521	broad.mit.edu	37	chr17	20108086	20108086	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	actttcagaaagagctttccGatctagaggaagaaaaccgg	10	8	2	4	rs144644210		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:20108086G>A	uc002gwq.2	+	4	869	c.724G>A	c.(724-726)GAT>AAT	p.D242N	CYTSB_uc010cqx.2_Missense_Mutation_p.D242N|CYTSB_uc002gwr.2_Missense_Mutation_p.D242N|CYTSB_uc002gws.2_Missense_Mutation_p.D242N|CYTSB_uc002gwv.2_Missense_Mutation_p.D161N|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.D18N|CYTSB_uc002gwt.2_Missense_Mutation_p.D161N|CYTSB_uc002gwu.2_Missense_Mutation_p.D161N	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	242						nucleus					0						AGAGCTTTCCGATCTAGAGGA	0.498													0	0	0	0.008361	0	28	110										A	20108086	G	A	20108086	3	1	114	1	0	0	0	0	1	0	0	0	4210	1058	37	1	778	1	CYTSB	17	20108086	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	19079409	20108086	61087124	118	34511										
JUP	3728	broad.mit.edu	37	chr17	39681230	39681231	+	Frame_Shift_Ins	INS	-	-	AG													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cggcctccacgctcatgcgcINSagagcctgttccgtctcaaa							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:39681230_39681231insAG	uc010wfs.1	-	6	1021_1022	c.1013_1014insCT	c.(1012-1014)CTGfs	p.L338fs	KRT19_uc002hxd.3_Frame_Shift_Ins_p.L175fs	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CGCTCATGCGCAGAGCCTGTTC	0.584																		77	120	---	---								AG	39681231	-	AG	39681230	7	5	114	1	0	1	1	0	0	0	0	0	7972	697	25	0		0	JUP	17	39681230	Frame_Shift_Ins	INS	-	TCGA-GV-A3JV-01A-11D-A21Z-08	19573144	39681230	41513980	119	34512										
NBR1	4077	broad.mit.edu	37	chr17	41343528	41343528	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	aaattcacctgtggaattcaAtccatggactccagagcccc	7	13	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:41343528A>T	uc010czd.2	+	10	1143	c.1003A>T	c.(1003-1005)ATC>TTC	p.I335F	NBR1_uc010diz.2_Missense_Mutation_p.I335F|NBR1_uc010whu.1_Missense_Mutation_p.I335F|NBR1_uc010whv.1_Missense_Mutation_p.I335F|NBR1_uc010whw.1_Missense_Mutation_p.I314F|NBR1_uc010whx.1_Missense_Mutation_p.I144F	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	335					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GTGGAATTCAATCCATGGACT	0.478													0	0	0	0.009096	0	3	11										T	41343528	A	T	41343528	3	4	114	1	0	0	0	0	1	0	0	0	10200	101	4	5	1037	5	NBR1	17	41343528	Missense_Mutation	SNP	A	TCGA-GV-A3JV-01A-11D-A21Z-08	1662298	41343528	39851682	120	34513										
CACNA1G	8913	broad.mit.edu	37	chr17	48649340	48649340	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcatcttcggcatcgtcggcGtccagctgtgggcagggctg	15	12	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:48649340G>A	uc002irk.1	+	5	1060	c.688G>A	c.(688-690)GTC>ATC	p.V230I	CACNA1G_uc002iri.1_Missense_Mutation_p.V230I|CACNA1G_uc002irj.1_Missense_Mutation_p.V230I|CACNA1G_uc002irl.1_Missense_Mutation_p.V230I|CACNA1G_uc002irm.1_Missense_Mutation_p.V230I|CACNA1G_uc002irn.1_Missense_Mutation_p.V230I|CACNA1G_uc002iro.1_Missense_Mutation_p.V230I|CACNA1G_uc002irp.1_Missense_Mutation_p.V230I|CACNA1G_uc002irq.1_Missense_Mutation_p.V230I|CACNA1G_uc002irr.1_Missense_Mutation_p.V230I|CACNA1G_uc002irs.1_Missense_Mutation_p.V230I|CACNA1G_uc002irt.1_Missense_Mutation_p.V230I|CACNA1G_uc002irv.1_Missense_Mutation_p.V230I|CACNA1G_uc002irw.1_Missense_Mutation_p.V230I|CACNA1G_uc002iru.1_Missense_Mutation_p.V230I|CACNA1G_uc002irx.1_Missense_Mutation_p.V143I|CACNA1G_uc002iry.1_Missense_Mutation_p.V143I|CACNA1G_uc002irz.1_Missense_Mutation_p.V143I|CACNA1G_uc002isa.1_Missense_Mutation_p.V143I|CACNA1G_uc002isb.1_Missense_Mutation_p.V143I|CACNA1G_uc002isc.1_Missense_Mutation_p.V143I|CACNA1G_uc002isd.1_Missense_Mutation_p.V143I|CACNA1G_uc002ise.1_Missense_Mutation_p.V143I|CACNA1G_uc002isf.1_Missense_Mutation_p.V143I|CACNA1G_uc002isg.1_Missense_Mutation_p.V143I|CACNA1G_uc002ish.1_Missense_Mutation_p.V143I|CACNA1G_uc002isi.1_Missense_Mutation_p.V143I	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	230	I.|Helical; Name=S5 of repeat I; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CATCGTCGGCGTCCAGCTGTG	0.587													0	0	0	0.016723	0	14	32										A	48649340	G	A	48649340	3	1	114	1	0	0	0	0	1	0	0	0	2544	1145	40	2	706	2	CACNA1G	17	48649340	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	7305812	48649340	32545870	121	34514										
KCNJ2	3759	broad.mit.edu	37	chr17	68172154	68172154	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgaaatcctgtggggccaccGctatgagcctgtgctctttg	12	11	1	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:68172154G>A	uc010dfg.2	+	2	1375	c.974G>A	c.(973-975)CGC>CAC	p.R325H	KCNJ2_uc002jir.2_Missense_Mutation_p.R325H	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	325	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					TGGGGCCACCGCTATGAGCCT	0.493													0	0	0	0.013537	0	12	57										A	68172154	G	A	68172154	3	1	114	1	0	0	0	0	1	0	0	0	8051	1087	38	2	976	2	KCNJ2	17	68172154	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	19522814	68172154	13023056	122	34515										
ST6GALNAC1	55808	broad.mit.edu	37	chr17	74625715	74625716	+	Frame_Shift_Del	DEL	TG	TG	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcatagatggttgtcctcctTgcccttgtgggtgcctggga					rs8081258	byFrequency	TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr17:74625715_74625716delTG	uc002jsh.2	-	2	383_384	c.209_210delCA	c.(208-210)GCAfs	p.A70fs	ST6GALNAC1_uc002jsi.2_5'UTR|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	70	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						TTGTCCTCCTTGCCCTTGTGGG	0.535																		70	141	---	---								-	74625716	TG	-	74625715	7	5	114	1	0	1	0	1	0	0	0	0	15222	1799	63	0	1624	0	ST6GALNAC1	17	74625715	Frame_Shift_Del	DEL	TG	TCGA-GV-A3JV-01A-11D-A21Z-08	6453561	74625715	6569495	123	34516										
ESCO1	114799	broad.mit.edu	37	chr18	19112474	19112474	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	agaagcaattttcttccgacGcatcatgctgaatacccata	6	11	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr18:19112474G>A	uc002kth.1	-	11	3269	c.2335C>T	c.(2335-2337)CGT>TGT	p.R779C	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	779					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						TTCTTCCGACGCATCATGCTG	0.408													0	0	0	0.008291	0	9	103										A	19112474	G	A	19112474	3	1	114	1	0	0	0	0	1	0	0	0	5248	1087	38	2	195	2	ESCO1	18	19112474	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		19112474	58964774	124	34517										
ESCO1	114799	broad.mit.edu	37	chr18	19154691	19154691	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atagtctcctttggacctgaTttttttgctagattcttttg	7	7	2	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr18:19154691T>C	uc002kth.1	-	4	1048	c.114A>G	c.(112-114)AAA>AAG	p.K38K	ESCO1_uc002kti.1_RNA	NM_052911	NP_443143	Q5FWF5	ESCO1_HUMAN	establishment of cohesion 1 homolog 1	38					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding				0						TTGGACCTGATTTTTTTGCTA	0.338													0	0	0	0.019004	0	36	29										C	19154691	T	C	19154691	2	2	114	1	0	0	0	0	0	0	0	1	5248	1490	52	5		5	ESCO1	18	19154691	Silent	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08	42217	19154691	58922557	125	34518										
DCC	1630	broad.mit.edu	37	chr18	50731606	50731606	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgcaagttccagggccagtaGaaaacctgcaagctgtatct	10	10	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr18:50731606G>A	uc002lfe.1	+	10	2181	c.1594G>A	c.(1594-1596)GAA>AAA	p.E532K	DCC_uc010xdr.1_Missense_Mutation_p.E380K|DCC_uc010dpf.1_Missense_Mutation_p.E187K	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	532	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGGGCCAGTAGAAAACCTGCA	0.388													0	0	0	0.01441	0	47	163										A	50731606	G	A	50731606	3	1	114	1	0	0	0	0	1	0	0	0	4282	943	33	1	1632	1	DCC	18	50731606	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	31576915	50731606	27345642	126	34519										
FSTL3	10272	broad.mit.edu	37	chr19	681360	681360	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tgagcacgtggtgtgcccgcGgccacagtcgtgcgtcgtgg	17	12	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:681360G>A	uc002lpk.1	+	4	568	c.533G>A	c.(532-534)CGG>CAG	p.R178Q	FSTL3_uc010drt.1_RNA	NM_005860	NP_005851	O95633	FSTL3_HUMAN	follistatin-like 3 glycoprotein precursor	178	Follistatin-like 2.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of osteoclast differentiation|ossification|positive regulation of cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	extracellular space|nucleus	activin binding|fibronectin binding				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTGCCCGCGGCCACAGTCG	0.701			T	CCND1	B-CLL								0	0	0	0.006214	0	6	11										A	681360	G	A	681360	3	1	114	1	0	0	0	0	1	0	0	0	6078	1116	39	2	547	2	FSTL3	19	681360	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		681360	58447623	127	34520										
ZNF414	84330	broad.mit.edu	37	chr19	8576365	8576365	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctccctggtggtcacctgcaCgcacctgagggcgcgtcgga	14	15	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:8576365C>T	uc002mkf.2	-	6	1048	c.930G>A	c.(928-930)GCG>GCA	p.A310A	ZNF414_uc002mke.3_Intron|ZNF414_uc010dwf.2_Silent_p.A299A	NM_032370	NP_115746	Q96IQ9	ZN414_HUMAN	zinc finger protein 414 isoform 2	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCACCTGCACGCACCTGAGG	0.687													0	0	0	0.013537	0	10	21										T	8576365	C	T	8576365	2	4	114	1	0	0	0	0	0	0	0	1	17888	523	19	2		2	ZNF414	19	8576365	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	7895005	8576365	50552618	128	34521										
ADAMTS10	81794	broad.mit.edu	37	chr19	8665902	8665902	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gccaccaccagggtctccacGtagcgctctcggctgaccga	11	17	2	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:8665902G>A	uc002mkj.1	-	6	994	c.720C>T	c.(718-720)TAC>TAT	p.Y240Y	ADAMTS10_uc002mkk.1_Translation_Start_Site	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	240	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GGGTCTCCACGTAGCGCTCTC	0.622													0	0	0	0.021022	0	35	104										A	8665902	G	A	8665902	2	1	114	1	0	0	0	0	0	0	0	1	256	1140	40	2		2	ADAMTS10	19	8665902	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	89537	8665902	50463081	129	34522										
MUC16	94025	broad.mit.edu	37	chr19	8996396	8996396	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtgggtcagctggctcagctCccaatacagctgctctctgt	11	13	3	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:8996396C>G	uc002mkp.2	-	61	41380	c.41176G>C	c.(41176-41178)GAG>CAG	p.E13726Q	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.E543Q|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13728	Extracellular (Potential).|SEA 11.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCTCAGCTCCCAATACAGC	0.567													0	0	0	0.01441	0	54	108										G	8996396	C	G	8996396	3	3	114	1	0	0	0	0	1	0	0	0	9973	864	30	1	2443	1	MUC16	19	8996396	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	330494	8996396	50132587	130	34523										
ZNF844	284391	broad.mit.edu	37	chr19	12187307	12187307	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcaatgtgggaaagccttcaGatctgcctcacaccttcaaa	8	12	4	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:12187307G>C	uc002mtb.2	+	4	1515	c.1372G>C	c.(1372-1374)GAT>CAT	p.D458H	ZNF844_uc010dym.1_Missense_Mutation_p.D301H	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	458					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAAGCCTTCAGATCTGCCTCA	0.423													0	0	0	0.009096	0	4	105										C	12187307	G	C	12187307	3	2	114	1	0	0	0	0	1	0	0	0	18187	942	33	1	1386	1	ZNF844	19	12187307	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	3190911	12187307	46941676	131	34524										
CD97	976	broad.mit.edu	37	chr19	14512345	14512345	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccaagagcctgcctaaaggcCccttcacctacatttcccct	5	18	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:14512345C>T	uc002myl.2	+	10	1168	c.1045C>T	c.(1045-1047)CCC>TCC	p.P349S	CD97_uc002mym.2_Missense_Mutation_p.P300S|CD97_uc002myn.2_Missense_Mutation_p.P256S	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	349	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						GCCTAAAGGCCCCTTCACCTA	0.612													0	0	0	0.013537	0	11	71										T	14512345	C	T	14512345	3	4	114	1	0	0	0	0	1	0	0	0	3049	623	22	2	1083	2	CD97	19	14512345	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	2325038	14512345	44616638	132	34525										
ZNF529	57711	broad.mit.edu	37	chr19	37038913	37038913	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atattcatcaaactctaagtCacaactgaagaccttctcat	3	11	5	2			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:37038913C>T	uc002oeh.3	-	5	749	c.547G>A	c.(547-549)GAC>AAC	p.D183N	ZNF529_uc010xth.1_Missense_Mutation_p.D183N|ZNF529_uc010xti.1_Missense_Mutation_p.D165N|ZNF529_uc002oeg.3_Missense_Mutation_p.D78N	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					AACTCTAAGTCACAACTGAAG	0.363													0	0	0	0.014323	0	23	24										T	37038913	C	T	37038913	3	4	114	1	0	0	0	0	1	0	0	0	17967	826	29	1	1148	1	ZNF529	19	37038913	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	22526568	37038913	22090070	133	34526										
CYP2A6	1548	broad.mit.edu	37	chr19	41354273	41354273	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gctcaggaagaaggtgggatCgatattggcgcctgcgggta	17	7	1	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:41354273C>T	uc002opl.3	-	4	526	c.505G>A	c.(505-507)GAT>AAT	p.D169N	CYP2A6_uc010ehe.1_5'UTR|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	169					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	AAGGTGGGATCGATATTGGCG	0.542													0	0	0	0.00632	0	17	95										T	41354273	C	T	41354273	3	4	114	1	0	0	0	0	1	0	0	0	4162	884	31	1	1003	1	CYP2A6	19	41354273	Missense_Mutation	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	4315360	41354273	17774710	134	34527										
ZNF534	147658	broad.mit.edu	37	chr19	52954586	52954586	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ctctgctaccatttccttccGtttctgcttcgcttggcgat	7	14	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:52954586G>A	uc002pzj.1	+	5	543	c.418G>A	c.(418-420)GTT>ATT	p.V140I	ZNF534_uc010epo.1_Missense_Mutation_p.V97I|ZNF578_uc002pzm.2_5'Flank|ZNF578_uc002pzn.2_5'Flank|ZNF578_uc002pzp.3_5'Flank|ZNF578_uc002pzo.1_5'Flank|ZNF578_uc010epp.1_5'Flank			Q76KX8	ZN534_HUMAN	SubName: Full=Putative uncharacterized protein;	Error:Variant_position_missing_in_Q76KX8_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTCCTTCCGTTTCTGCTTC	0.682													0	0	0	0.014758	0	4	8										A	52954586	G	A	52954586	3	1	114	1	0	0	0	0	1	0	0	0	17970	1160	40	2		2	ZNF534	19	52954586	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	11600313	52954586	6174397	135	34528										
ZNF578	147660	broad.mit.edu	37	chr19	53014654	53014654	+	Frame_Shift_Del	DEL	G	G	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cataggtgtcacactggtgaGaaaccttacaagtgtaatga							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr19:53014654delG	uc002pzp.3	+	6	1264	c.1020delG	c.(1018-1020)GAGfs	p.E340fs		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ACACTGGTGAGAAACCTTACA	0.403																		21	119	---	---								-	53014654	G	-	53014654	7	5	114	1	0	1	0	1	0	0	0	0	18007	933	33	0	1030	0	ZNF578	19	53014654	Frame_Shift_Del	DEL	G	TCGA-GV-A3JV-01A-11D-A21Z-08	60068	53014654	6114329	136	34529										
DEFB126	81623	broad.mit.edu	37	chr20	126332	126332	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccccgtttctcccactggttGaacattccagcctctgtctc	6	17	3	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:126332G>A	uc002wcx.2	+	2	353	c.335G>A	c.(334-336)TGA>TAA	p.*112*		NM_030931	NP_112193	Q9BYW3	DB126_HUMAN	defensin, beta 126 preproprotein	112					defense response to bacterium	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			CCCACTGGTTGAACATTCCAG	0.408													0	0	0	0.011902	0	33	178										A	126332	G	A	126332	2	1	114	1	0	0	0	0	0	0	0	1	4412	1285	45	1		1	DEFB126	20	126332	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		126332	62899188	137	34530										
C20orf186	149954	broad.mit.edu	37	chr20	31685499	31685501	+	In_Frame_Del	DEL	AGA	AGA	-													0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccaccatctgtgatgctgcAgaaggacaaagcgctggtga							TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:31685499_31685501delAGA	uc010zue.1	+	11	1490_1492	c.1475_1477delAGA	c.(1474-1479)CAGAAG>CAG	p.K493del		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	493						cytoplasm|extracellular region	lipid binding				0						GTGATGCTGCAGAAGGACAAAGC	0.576																		28	140	---	---								-	31685501	AGA	-	31685499	7	5	114	1	0	1	0	1	0	0	0	0	2098	188	7	0	1517	0	C20orf186	20	31685499	In_Frame_Del	DEL	AGA	TCGA-GV-A3JV-01A-11D-A21Z-08	31559167	31685499	31340021	138	34531										
RALGAPB	57148	broad.mit.edu	37	chr20	37117126	37117126	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gtgattcagaatgatcaaggCcataccagtgtgctgcacag	11	9	2	3			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:37117126C>T	uc002xiw.2	+	2	308	c.51C>T	c.(49-51)GGC>GGT	p.G17G	RALGAPB_uc010zvz.1_Silent_p.G17G|RALGAPB_uc002xix.2_Silent_p.G17G|RALGAPB_uc002xiy.1_Silent_p.G17G	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	17					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						ATGATCAAGGCCATACCAGTG	0.493													0	0	0	0.019004	0	31	154										T	37117126	C	T	37117126	2	4	114	1	0	0	0	0	0	0	0	1	13015	726	26	2		2	RALGAPB	20	37117126	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	5431627	37117126	25908394	139	34532										
TOMM34	10953	broad.mit.edu	37	chr20	43572202	43572202	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	gcttctgtgtactgcttcagGaccaaatagcagagtgctct	10	10	3	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr20:43572202G>A	uc002xmy.2	-	6	857	c.717C>T	c.(715-717)GTC>GTT	p.V239V	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	239	TPR 5.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				ACTGCTTCAGGACCAAATAGC	0.493													0	0	0	0.008871	0	17	84										A	43572202	G	A	43572202	2	1	114	1	0	0	0	0	0	0	0	1	16354	1161	41	1		1	TOMM34	20	43572202	Silent	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	6455076	43572202	19453318	140	34533										
SFRS15	57466	broad.mit.edu	37	chr21	33065763	33065763	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	atgccgagaccttcgagatcTagaaccagatctagatcgcc	9	12	2	5			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr21:33065763T>C	uc002ypd.2	-	12	1783	c.1357A>G	c.(1357-1359)AGA>GGA	p.R453G	SFRS15_uc002ype.2_Missense_Mutation_p.R453G|SFRS15_uc010glu.2_Missense_Mutation_p.R438G|SFRS15_uc002ypf.1_Missense_Mutation_p.R127G	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	453						nucleus	nucleotide binding|RNA binding				0						CTTCGAGATCTAGAACCAGAT	0.453													0	0	0	0.013726	0	25	11										C	33065763	T	C	33065763	3	2	114	1	0	0	0	0	1	0	0	0	14171	1530	53	5	2122	5	SFRS15	21	33065763	Missense_Mutation	SNP	T	TCGA-GV-A3JV-01A-11D-A21Z-08		33065763	15064132	141	34534										
MN1	4330	broad.mit.edu	37	chr22	28193514	28193514	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	cccttcccccaggatggcgaCgtgagcgccttttcgtgggg	14	14	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr22:28193514C>T	uc003adj.2	-	1	3973	c.3018G>A	c.(3016-3018)ACG>ACA	p.T1006T		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1006							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						AGGATGGCGACGTGAGCGCCT	0.701			T	ETV6	AML|meningioma								0	0	0	0.00632	0	24	64										T	28193514	C	T	28193514	2	4	114	1	0	0	0	0	0	0	0	1	9673	523	19	2		2	MN1	22	28193514	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08		28193514	23111052	142	34535										
MAPK11	5600	broad.mit.edu	37	chr22	50705688	50705688	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccctgcggtcgcacctacccGgtggatgatcccggccgagt	13	16	0	1			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chr22:50705688G>A	uc003bkr.2	-	5	503	c.445C>T	c.(445-447)CGG>TGG	p.R149W	MAPK11_uc010hax.2_5'UTR|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_Missense_Mutation_p.P129L|MAPK11_uc010haz.2_Missense_Mutation_p.R41W	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	149	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCACCTACCCGGTGGATGATC	0.587													0	0	0	0.001984	0	4	22										A	50705688	G	A	50705688	3	1	114	1	0	0	0	0	1	0	0	0	9273	1115	39	2	681	2	MAPK11	22	50705688	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08	22512174	50705688	598878	143	34536										
CLCN4	1183	broad.mit.edu	37	chrX	10188760	10188760	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	ccatcatgtacttcacggagGaaccccccgagctgccggcc	10	17	2	0			TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chrX:10188760G>A	uc004csy.3	+	12	2465	c.2035G>A	c.(2035-2037)GAA>AAA	p.E679K	CLCN4_uc011mid.1_Missense_Mutation_p.E585K	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	679	Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CTTCACGGAGGAACCCCCCGA	0.567													0	0	0	0.01441	0	109	35										A	10188760	G	A	10188760	3	1	114	1	0	0	0	0	1	0	0	0	3465	1175	41	1	2073	1	CLCN4	23	10188760	Missense_Mutation	SNP	G	TCGA-GV-A3JV-01A-11D-A21Z-08		10188760	145081800	144	34537										
XAGE5	170627	broad.mit.edu	37	chrX	52844174	52844174	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.159722222222222	23	0.00692547715793835	1.74461346762889	2.84103062712688	1.61352011160195	9.60182780261739e-05	0.000567380733791028	10	tcaaagactggggatgaatgCggagatagtcctgatgtcca	13	7	1	4	rs146352090		TCGA-GV-A3JV-01A-11D-A21Z-08	TCGA-GV-A3JV-10B-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5fed4b8a-4b59-4424-bbf1-bc73ce041361	f9fd3c7e-20a6-4d48-a45b-6482fdc10173	g.chrX:52844174C>T	uc004drd.1	+	4	302	c.237C>T	c.(235-237)TGC>TGT	p.C79C		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	79										ovary(1)	1						GGGATGAATGCGGAGATAGTC	0.438													0	0	0	0.008361	0	26	47										T	52844174	C	T	52844174	2	4	114	1	0	0	0	0	0	0	0	1	17418	776	27	2		2	XAGE5	23	52844174	Silent	SNP	C	TCGA-GV-A3JV-01A-11D-A21Z-08	42655414	52844174	102426386	145	34538										
C8A	731	broad.mit.edu	37	chr1	57373628	57373628	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agtttatcctcttgatggcaGaaagggccaggaaggccatg	13	8	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:57373628G>A	uc001cyo.2	+	9	1355	c.1223_splice	c.e9-1	p.E408_splice		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						CTTGATGGCAGAAAGGGCCAG	0.488													0	0	0	0.049695	0	14	38										A	57373628	G	A	57373628	5	1	115	1	0	0	0	0	0	0	1	0	2416	956	33	1	1256	1	C8A	1	57373628	Splice_Site	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		57373628	191876993	1	34539										
OR6N2	81442	broad.mit.edu	37	chr1	158746645	158746645	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggaatagctcttctttagccGcacatacatgaagatgatgc	9	9	2	3			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:158746645G>A	uc010pir.1	-	1	781	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TTCTTTAGCCGCACATACATG	0.433													0	0	0	0.09319	0	12	38										A	158746645	G	A	158746645	3	1	115	1	0	0	0	0	1	0	0	0	11207	1086	38	2	175	2	OR6N2	1	158746645	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	101373017	158746645	90503976	2	34540										
DNM3	26052	broad.mit.edu	37	chr1	171890908	171890908	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggactttctccctcgagggtCgggcattgtaacaagacgac	12	11	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:171890908C>T	uc001gie.2	+	2	358	c.182C>T	c.(181-183)TCG>TTG	p.S61L	DNM3_uc001gid.3_Missense_Mutation_p.S61L|DNM3_uc009wwb.2_Missense_Mutation_p.S61L|DNM3_uc001gif.2_Missense_Mutation_p.S61L	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	61					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						CCTCGAGGGTCGGGCATTGTA	0.433													0	0	0	0.080935	0	9	10										T	171890908	C	T	171890908	3	4	115	1	0	0	0	0	1	0	0	0	4673	893	31	1	188	1	DNM3	1	171890908	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	13144263	171890908	77359713	3	34541										
PROX1	5629	broad.mit.edu	37	chr1	214184960	214184960	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agtacgcacgtcaagccatcAacgatggggtcaccagtact	10	12	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr1:214184960A>C	uc001hkh.2	+	4	2202	c.1930A>C	c.(1930-1932)AAC>CAC	p.N644H		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	644	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TCAAGCCATCAACGATGGGGT	0.443													0	0	0	0.139131	0	64	8										C	214184960	A	C	214184960	3	2	115	1	0	0	0	0	1	0	0	0	12560	130	5	5	1940	5	PROX1	1	214184960	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	42294052	214184960	35065661	4	34542										
ZNF513	130557	broad.mit.edu	37	chr2	27600891	27600892	+	Frame_Shift_Del	DEL	TG	TG	-													0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gcggaagggcttctcaccacTgtgtgtcttcatgtgccggg							TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:27600891_27600892delTG	uc002rkk.2	-	4	1346_1347	c.1146_1147delCA	c.(1144-1149)CACAGTfs	p.H382fs	ZNF513_uc002rkj.2_Frame_Shift_Del_p.H320fs	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	382_383					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding	p.S383C(1)		ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTCACCACTGTGTGTCTTCA	0.609																		57	160	---	---								-	27600892	TG	-	27600891	7	5	115	1	0	1	0	1	0	0	0	0	17955	1580	55	0	482	0	ZNF513	2	27600891	Frame_Shift_Del	DEL	TG	TCGA-GV-A3JW-01A-11D-A20D-08		27600891	215598482	5	34543										
GPAT2	150763	broad.mit.edu	37	chr2	96698049	96698049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggaggagccacattacctctCggccactggggctgctcctt	12	14	1	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:96698049C>T	uc002svf.2	-	2	282	c.59G>A	c.(58-60)CGA>CAA	p.R20Q	GPAT2_uc002svg.2_5'UTR|GPAT2_uc010yuh.1_Missense_Mutation_p.R20Q|GPAT2_uc002svh.2_Missense_Mutation_p.R20Q	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	20					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						CATTACCTCTCGGCCACTGGG	0.572													0	0	0	0.058154	0	6	44										T	96698049	C	T	96698049	3	4	115	1	0	0	0	0	1	0	0	0	6589	884	31	1	2412	1	GPAT2	2	96698049	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	69097158	96698049	146501324	6	34544										
IL18R1	8809	broad.mit.edu	37	chr2	103013325	103013325	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agagacgaaccggaagtcttGcctgttctttccgagtctta	10	10	3	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:103013325G>A	uc002tbw.3	+	11	1755	c.1605G>A	c.(1603-1605)TTG>TTA	p.L535L	IL18R1_uc010ywc.1_Silent_p.L534L|IL18R1_uc010ywd.1_Silent_p.L379L|IL18R1_uc010fiy.2_Silent_p.L535L	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	535	Cytoplasmic (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						CGGAAGTCTTGCCTGTTCTTT	0.413													0	0	0	0.080935	0	9	21										A	103013325	G	A	103013325	2	1	115	1	0	0	0	0	0	0	0	1	7647	1310	46	2		2	IL18R1	2	103013325	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	6315276	103013325	140186048	7	34545										
SULT1C4	27233	broad.mit.edu	37	chr2	108994731	108994731	+	Translation_Start_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agtgctgcctctatccacaaCgcagccatatgctgactgaa	8	13	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr2:108994731C>T	uc002tea.1	+	1	311	c.-62C>T	c.(-64--60)AACGC>AATGC		SULT1C4_uc002tdz.2_Translation_Start_Site|SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Translation_Start_Site	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member						3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						CTATCCACAACGCAGCCATAT	0.488													0	0	0	0.02938	0	7	29										T	108994731	C	T	108994731	1	4	115	1	0	0	0	0	0	0	0	0	15376	551	19	2		2	SULT1C4	2	108994731	Translation_Start_Site	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	5981406	108994731	134204642	8	34546										
EDEM1	9695	broad.mit.edu	37	chr3	5249807	5249807	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggagatgtggaagatgccatCtgccttcatgccttctacta	10	10	3	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:5249807C>T	uc003bqi.2	+	8	1500	c.1368C>T	c.(1366-1368)ATC>ATT	p.I456I	EDEM1_uc011asz.1_Silent_p.I234I|EDEM1_uc003bqh.2_Silent_p.I456I	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	456	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		AAGATGCCATCTGCCTTCATG	0.512													0	0	0	0.139131	0	47	93										T	5249807	C	T	5249807	2	4	115	1	0	0	0	0	0	0	0	1	4911	903	32	1		1	EDEM1	3	5249807	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		5249807	192772623	9	34547										
IRAK2	3656	broad.mit.edu	37	chr3	10264330	10264330	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	atttccacagctctaatgtcTtgctggaccaaaatctcacc	5	13	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:10264330T>G	uc003bve.1	+	9	1100	c.1024T>G	c.(1024-1026)TTG>GTG	p.L342V		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	342	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						CTCTAATGTCTTGCTGGACCA	0.453													0	0	0	0.139131	0	64	259										G	10264330	T	G	10264330	3	3	115	1	0	0	0	0	1	0	0	0	7823	1606	56	5	1058	5	IRAK2	3	10264330	Missense_Mutation	SNP	T	TCGA-GV-A3JW-01A-11D-A20D-08	5014523	10264330	187758100	10	34548										
SEC13	6396	broad.mit.edu	37	chr3	10342968	10342968	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ctgctcgttctgctggccctCtgtcactgatgctgatacgg	11	13	3	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:10342968C>G	uc003bvn.2	-	9	1065	c.946G>C	c.(946-948)GAG>CAG	p.E316Q	SEC13_uc003bvl.2_Missense_Mutation_p.E248Q|SEC13_uc003bvm.2_Missense_Mutation_p.E302Q|SEC13_uc003bvp.2_Missense_Mutation_p.E319Q|SEC13_uc003bvo.2_Missense_Mutation_p.E362Q|SEC13_uc003bvq.1_Intron	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	316					COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						TGCTGGCCCTCTGTCACTGAT	0.607													0	0	0	0.125774	0	24	236										G	10342968	C	G	10342968	3	3	115	1	0	0	0	0	1	0	0	0	13980	922	32	1	26	1	SEC13	3	10342968	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	78638	10342968	187679462	11	34549										
PDCD6IP	10015	broad.mit.edu	37	chr3	33870428	33870428	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tctatcctggcaaaacagcaGaagaaatttggagaagaaat	9	6	1	4			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:33870428G>A	uc003cfx.2	+	7	956	c.801G>A	c.(799-801)CAG>CAA	p.Q267Q	PDCD6IP_uc003cfy.2_Silent_p.Q272Q|PDCD6IP_uc011axw.1_Silent_p.Q48Q	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	267	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.|BRO1.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						CAAAACAGCAGAAGAAATTTG	0.388													0	0	0	0.0333	0	13	43										A	33870428	G	A	33870428	2	1	115	1	0	0	0	0	0	0	0	1	11624	933	33	1		1	PDCD6IP	3	33870428	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	23527460	33870428	164152002	12	34550										
COL6A6	131873	broad.mit.edu	37	chr3	130285707	130285707	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ttggggccgttcagtatgctGacagctgggacttggaattt	14	7	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:130285707G>A	uc010htl.2	+	4	1475	c.1444G>A	c.(1444-1446)GAC>AAC	p.D482N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	482	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCAGTATGCTGACAGCTGGGA	0.478													0	0	0	0.059317	0	27	124										A	130285707	G	A	130285707	3	1	115	1	0	0	0	0	1	0	0	0	3703	1290	45	1	1458	1	COL6A6	3	130285707	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	96415279	130285707	67736723	13	34551										
ACPL2	92370	broad.mit.edu	37	chr3	141011518	141011518	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gctctgccacttctgccacaAtgtcagctttccctgtacca	6	16	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:141011518A>G	uc003etu.2	+	8	1213	c.914A>G	c.(913-915)AAT>AGT	p.N305S	ACPL2_uc003etv.2_Missense_Mutation_p.N305S|ACPL2_uc011bna.1_Missense_Mutation_p.N267S|ACPL2_uc011bnb.1_Missense_Mutation_p.N288S	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	305						extracellular region	acid phosphatase activity			skin(1)	1						TTCTGCCACAATGTCAGCTTT	0.517													0	0	0	0.105934	0	12	79										G	141011518	A	G	141011518	3	3	115	1	0	0	0	0	1	0	0	0	166	101	4	5	932	5	ACPL2	3	141011518	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	10725811	141011518	57010912	14	34552										
LSG1	55341	broad.mit.edu	37	chr3	194373664	194373664	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ttccttgggaccgtcttcttCtgagcacgtctgccagtcgt	10	13	4	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:194373664C>T	uc003fui.2	-	8	1282	c.967G>A	c.(967-969)GAA>AAA	p.E323K		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	323					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		CCGTCTTCTTCTGAGCACGTC	0.527													0	0	0	0.009096	0	4	70										T	194373664	C	T	194373664	3	4	115	1	0	0	0	0	1	0	0	0	9049	922	32	1	1037	1	LSG1	3	194373664	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	53362146	194373664	3648766	15	34553										
MUC4	4585	broad.mit.edu	37	chr3	195512118	195512118	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gcatcggtgtcatgaagagcGgtggcgtgacctgtggatac	16	8	1	3			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr3:195512118G>A	uc011bto.1	-	2	6793	c.6333C>T	c.(6331-6333)ACC>ACT	p.T2111T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	886	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CATGAAGAGCGGTGGCGTGAC	0.572													0	0	0	0.115264	0	3	5										A	195512118	G	A	195512118	2	1	115	1	0	0	0	0	0	0	0	1	9978	1103	39	2		2	MUC4	3	195512118	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	1138454	195512118	2510312	16	34554										
BMP2K	55589	broad.mit.edu	37	chr4	79832995	79832995	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cgtgctgatcacaatactgtCctgccagggcggccaagaca	11	13	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:79832995C>T	uc003hlk.2	+	16	3460	c.3294C>T	c.(3292-3294)GTC>GTT	p.V1098V	PAQR3_uc003hlm.2_Intron|PAQR3_uc003hln.2_Intron|uc010ijm.1_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	1098						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						ACAATACTGTCCTGCCAGGGC	0.517													0	0	0	0.02938	0	5	46										T	79832995	C	T	79832995	2	4	115	1	0	0	0	0	0	0	0	1	1460	842	30	1		1	BMP2K	4	79832995	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		79832995	111321281	17	34555										
HNRPDL	9987	broad.mit.edu	37	chr4	83348369	83348369	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cacgacccctcgtaccacctCgtccaccagctgcagcacct	6	21	0	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr4:83348369C>T	uc003hmr.2	-	5	1530	c.995G>A	c.(994-996)CGA>CAA	p.R332Q	HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.R332Q	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	332	Gly-rich.				regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				CGTACCACCTCGTCCACCAGC	0.438													0	0	0	0.139131	0	66	165										T	83348369	C	T	83348369	3	4	115	1	0	0	0	0	1	0	0	0	7276	884	31	1	279	1	HNRPDL	4	83348369	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	3515374	83348369	107805907	18	34556										
HCN1	348980	broad.mit.edu	37	chr5	45262592	45262592	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tacaggagggctgcagaccgCggtggtgtaggagcagggtg	20	7	0	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:45262592C>T	uc003jok.2	-	8	2129	c.2104G>A	c.(2104-2106)GCG>ACG	p.A702T		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	702	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTGCAGACCGCGGTGGTGTAG	0.592													0	0	0	0.0333	0	15	4										T	45262592	C	T	45262592	3	4	115	1	0	0	0	0	1	0	0	0	6996	768	27	2	572	2	HCN1	5	45262592	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		45262592	135652668	19	34557										
DDX4	54514	broad.mit.edu	37	chr5	55088541	55088541	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tggatatgggttttggtccaGaaatgaagaagttaatttct	11	3	1	3			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:55088541G>A	uc003jqg.3	+	17	1449	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	DDX4_uc010ivz.2_Missense_Mutation_p.E439K|DDX4_uc003jqh.3_Missense_Mutation_p.E425K|DDX4_uc003jqj.2_Missense_Mutation_p.E310K	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	459	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TTTTGGTCCAGAAATGAAGAA	0.378													0	0	0	0.062417	0	16	24										A	55088541	G	A	55088541	3	1	115	1	0	0	0	0	1	0	0	0	4360	943	33	1	1478	1	DDX4	5	55088541	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	9825949	55088541	125826719	20	34558										
DDX4	54514	broad.mit.edu	37	chr5	55094390	55094390	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aaaagctcgttgaaattctgCgaaacataggtatcttacgt	8	7	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:55094390C>G	uc003jqg.3	+	18	1680	c.1606C>G	c.(1606-1608)CGA>GGA	p.R536G	DDX4_uc010ivz.2_Missense_Mutation_p.R516G|DDX4_uc003jqh.3_Missense_Mutation_p.R502G|DDX4_uc003jqj.2_Missense_Mutation_p.R387G	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	536	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				TGAAATTCTGCGAAACATAGG	0.343													0	0	0	0.105934	0	12	18										G	55094390	C	G	55094390	3	3	115	1	0	0	0	0	1	0	0	0	4360	760	27	4	1713	4	DDX4	5	55094390	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	5849	55094390	125820870	21	34559										
ADAMTS6	11174	broad.mit.edu	37	chr5	64756014	64756014	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cacccgaaaccccacaatgaGagtgatcatacagatgtcgt	8	12	1	3			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:64756014G>C	uc003jtp.2	-	4	1428	c.614C>G	c.(613-615)TCT>TGT	p.S205C	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_5'UTR	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	205					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CCCACAATGAGAGTGATCATA	0.408													0	0	0	0.144211	0	24	29										C	64756014	G	C	64756014	3	2	115	1	0	0	0	0	1	0	0	0	270	942	33	1	2827	1	ADAMTS6	5	64756014	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	9661624	64756014	116159246	22	34560										
DMGDH	29958	broad.mit.edu	37	chr5	78294073	78294073	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	acatatgcgaaagccagactCttctggatgctgtagctata	9	9	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:78294073C>G	uc003kfs.2	-	16	2439	c.2433G>C	c.(2431-2433)AAG>AAC	p.K811N		NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	811					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		AAGCCAGACTCTTCTGGATGC	0.473													0	0	0	0.02938	0	7	11										G	78294073	C	G	78294073	3	3	115	1	0	0	0	0	1	0	0	0	4581	912	32	1	171	1	DMGDH	5	78294073	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	13538059	78294073	102621187	23	34561										
TSSK1B	83942	broad.mit.edu	37	chr5	112769745	112769745	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cagcagtggctgaggatctcGtcgatgtggagccgccggtt	16	10	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:112769745G>A	uc003kqm.2	-	1	984	c.792C>T	c.(790-792)GAC>GAT	p.D264D	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	264	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TGAGGATCTCGTCGATGTGGA	0.617													0	0	0	0.014758	0	4	32										A	112769745	G	A	112769745	2	1	115	1	0	0	0	0	0	0	0	1	16665	1136	40	2		2	TSSK1B	5	112769745	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	34475672	112769745	68145515	24	34562										
PCDHA2	56146	broad.mit.edu	37	chr5	140175132	140175132	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	taagcgaatctttgtctctcGtgctggggaaatcgctggac	12	9	2	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:140175132G>A	uc003lhd.2	+	1	689	c.583G>A	c.(583-585)GTG>ATG	p.V195M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.V195M|PCDHA2_uc011czy.1_Missense_Mutation_p.V195M	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	195	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTGTCTCTCGTGCTGGGGAA	0.463													0	0	0	0.116897	0	24	34										A	140175132	G	A	140175132	3	1	115	1	0	0	0	0	1	0	0	0	11524	1145	40	2	585	2	PCDHA2	5	140175132	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	27405387	140175132	40740128	25	34563										
PCDHGA9	56107	broad.mit.edu	37	chr5	140784367	140784367	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aaggccagtgagccagggctCttctcggtggggctgcacac	15	12	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:140784367C>T	uc003lkh.1	+	1	1848	c.1848C>T	c.(1846-1848)CTC>CTT	p.L616L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Silent_p.L616L	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	616	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAGGGCTCTTCTCGGTGG	0.597													0	0	0	0.076483	0	21	20										T	140784367	C	T	140784367	2	4	115	1	0	0	0	0	0	0	0	1	11561	900	32	1		1	PCDHGA9	5	140784367	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	609235	140784367	40130893	26	34564										
TCOF1	6949	broad.mit.edu	37	chr5	149755460	149755460	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gaggaggcaccagcagccatGactgcagctcaggtgaggcc	15	12	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr5:149755460G>C	uc003lry.2	+	12	1989	c.1881G>C	c.(1879-1881)ATG>ATC	p.M627I	TCOF1_uc003lrw.2_Missense_Mutation_p.M627I|TCOF1_uc011dch.1_Missense_Mutation_p.M627I|TCOF1_uc003lrz.2_Missense_Mutation_p.M627I|TCOF1_uc003lrx.2_Missense_Mutation_p.M550I|TCOF1_uc003lsa.2_Missense_Mutation_p.M550I|TCOF1_uc011dci.1_Missense_Mutation_p.M116I	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	627					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGCAGCCATGACTGCAGCTC	0.627													0	0	0	0.058154	0	7	18										C	149755460	G	C	149755460	3	2	115	1	0	0	0	0	1	0	0	0	15705	1290	45	1	1927	1	TCOF1	5	149755460	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	8971093	149755460	31159800	27	34565										
NHLRC1	378884	broad.mit.edu	37	chr6	18121856	18121856	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aatcacatttccctggtgatCaaaggtcacagcggaggcag	11	10	3	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18121856C>G	uc003ncl.1	-	1	996	c.982G>C	c.(982-984)GAT>CAT	p.D328H		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	328	NHL 5.				proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			CCCTGGTGATCAAAGGTCACA	0.483													0	0	0	0.139131	0	61	76										G	18121856	C	G	18121856	3	3	115	1	0	0	0	0	1	0	0	0	10405	826	29	1	209	1	NHLRC1	6	18121856	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		18121856	152993211	28	34566			1	159		3	3	931	C		4.146356e-06
NHLRC1	378884	broad.mit.edu	37	chr6	18122765	18122765	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ctcaaagcacaccttgcactCgagcaggctgatctccgcct	8	16	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18122765C>A	uc003ncl.1	-	1	87	c.73G>T	c.(73-75)GAG>TAG	p.E25*		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	25					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ACCTTGCACTCGAGCAGGCTG	0.711													1	0	9.39395e-14	0.116897	1.0348e-13	22	40										A	18122765	C	A	18122765	4	1	115	1	0	0	0	0	0	1	0	0	10405	893	31	3	1118	3	NHLRC1	6	18122765	Nonsense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	909	18122765	152992302	29	34567			1	159		3	3	931	C		4.146356e-06
NHLRC1	378884	broad.mit.edu	37	chr6	18122786	18122786	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gagcaggctgatctccgcctCgcgcatgagctcatgcagcg	13	14	2	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr6:18122786C>T	uc003ncl.1	-	1	66	c.52G>A	c.(52-54)GAG>AAG	p.E18K		NM_198586	NP_940988	Q6VVB1	NHLC1_HUMAN	NHL repeat containing 1	18					proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	endoplasmic reticulum|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.165)	all cancers(50;0.0451)|Epithelial(50;0.0493)			ATCTCCGCCTCGCGCATGAGC	0.711													0	0	0	0.083992	0	18	33										T	18122786	C	T	18122786	3	4	115	1	0	0	0	0	1	0	0	0	10405	893	31	1	1139	1	NHLRC1	6	18122786	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	21	18122786	152992281	30	34568			1	159		3	3	931	C		4.146356e-06
CPVL	54504	broad.mit.edu	37	chr7	29070210	29070210	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tacctgatggaagtcacccgCttgccggatgtaaccagcca	10	13	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:29070210C>G	uc003szv.2	-	12	1422	c.1303G>C	c.(1303-1305)GCG>CCG	p.A435P	CPVL_uc003szw.2_Missense_Mutation_p.A435P|CPVL_uc003szx.2_Missense_Mutation_p.A435P	NM_031311	NP_112601	Q9H3G5	CPVL_HUMAN	serine carboxypeptidase vitellogenic-like	435					proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2						AAGTCACCCGCTTGCCGGATG	0.478													0	0	0	0.139131	0	167	185										G	29070210	C	G	29070210	3	3	115	1	0	0	0	0	1	0	0	0	3835	797	28	4	135	4	CPVL	7	29070210	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		29070210	130068453	31	34569										
NOD1	10392	broad.mit.edu	37	chr7	30485764	30485764	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cccttctactcacccaacctCagagattgatttgctgttct	5	14	4	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:30485764C>G	uc003tav.2	-	9	2969	c.2446G>C	c.(2446-2448)GAG>CAG	p.E816Q		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	816					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CACCCAACCTCAGAGATTGAT	0.488													0	0	0	0.074837	0	29	398										G	30485764	C	G	30485764	3	3	115	1	0	0	0	0	1	0	0	0	10516	835	29	1	439	1	NOD1	7	30485764	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	1415554	30485764	128652899	32	34570										
AOAH	313	broad.mit.edu	37	chr7	36657936	36657936	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cttctcatatggaactccatCttttggatcgacacccttta	5	12	2	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:36657936C>G	uc003tfh.3	-	10	1119	c.718G>C	c.(718-720)GAT>CAT	p.D240H	AOAH_uc010kxf.2_Missense_Mutation_p.D240H|AOAH_uc011kba.1_Missense_Mutation_p.D208H	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	240					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						GGAACTCCATCTTTTGGATCG	0.308													0	0	0	0.09319	0	10	71										G	36657936	C	G	36657936	3	3	115	1	0	0	0	0	1	0	0	0	726	913	32	1	1398	1	AOAH	7	36657936	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	6172172	36657936	122480727	33	34571										
ZNF92	168374	broad.mit.edu	37	chr7	64863839	64863840	+	Missense_Mutation	DNP	CC	CC	AT													0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agcttttaaccggtcctcaaCccttactaaacataaaagaa							TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:64863839_64863840CC>AT	uc003ttz.2	+	4	955_956	c.812_813CC>AT	c.(811-813)ACC>AAT	p.T271N	ZNF92_uc003tua.2_Missense_Mutation_p.T202N|ZNF92_uc010kzu.2_Missense_Mutation_p.T239N|ZNF92_uc003tub.2_Missense_Mutation_p.T195N	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	271	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CGGTCCTCAACCCTTACTAAAC	0.351													0	0	0	0.115264	0	3	53										AT	64863840	CC	AT	64863839	3	1	115	1	0	0	0	0	1	0	0	0	18198	507	18	4	826	4	ZNF92	7	64863839	Missense_Mutation	DNP	CC	TCGA-GV-A3JW-01A-11D-A20D-08	28205903	64863839	94274824	34	34572										
CYP3A7	1551	broad.mit.edu	37	chr7	99308460	99308460	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agaacactgctcgtggtttcAtagccagcaaaaataaagat	8	8	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:99308460A>C	uc003uru.2	-	10	1026	c.921T>G	c.(919-921)TAT>TAG	p.Y307*	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	307					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TCGTGGTTTCATAGCCAGCAA	0.413													0	0	0	0.108266	0	24	40										C	99308460	A	C	99308460	4	2	115	1	0	0	0	0	0	1	0	0	4181	224	8	5	606	5	CYP3A7	7	99308460	Nonsense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	34444621	99308460	59830203	35	34573										
CAV2	858	broad.mit.edu	37	chr7	116139888	116139888	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gctcttcatggacgacgactCctacagccaccacagcggcc	9	17	2	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr7:116139888C>G	uc003vid.2	+	1	445	c.53C>G	c.(52-54)TCC>TGC	p.S18C	CAV2_uc003vhv.2_Intron|CAV2_uc003vhw.2_Intron|CAV2_uc003vhx.2_Intron|CAV2_uc010lkb.1_Intron|CAV2_uc010lkc.2_Intron|CAV2_uc003vib.2_Intron|CAV2_uc003vhz.2_Intron|CAV2_uc003via.2_Intron|CAV1_uc010lkd.1_Intron|CAV1_uc010lke.1_Intron|CAV2_uc003vie.2_Missense_Mutation_p.S18C	NM_001233	NP_001224	P51636	CAV2_HUMAN	caveolin 2 isoform a and b	18	Cytoplasmic (Potential).				caveola assembly|endoplasmic reticulum organization|mitochondrion organization|negative regulation of endothelial cell proliferation|positive regulation of dopamine receptor signaling pathway|regulation of mitosis|skeletal muscle fiber development|vesicle docking|vesicle fusion	caveola|extrinsic to internal side of plasma membrane|Golgi membrane|integral to plasma membrane|membrane fraction|nucleus|perinuclear region of cytoplasm|transport vesicle	D1 dopamine receptor binding|protein homodimerization activity				0	all_epithelial(6;1.53e-06)|Lung NSC(10;0.00592)|all_lung(10;0.00642)		STAD - Stomach adenocarcinoma(10;0.00878)			GACGACGACTCCTACAGCCAC	0.682													0	0	0	0.115264	0	2	2										G	116139888	C	G	116139888	3	3	115	1	0	0	0	0	1	0	0	0	2694	855	30	1	55	1	CAV2	7	116139888	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	16831428	116139888	42998775	36	34574										
ZNF395	55893	broad.mit.edu	37	chr8	28210752	28210752	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aggatcggtctcaaagccatGatcagtttggggagaaccaa	12	8	2	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:28210752G>A	uc003xgq.2	-	5	845	c.757C>T	c.(757-759)CAT>TAT	p.H253Y	ZNF395_uc003xgt.2_Missense_Mutation_p.H253Y|ZNF395_uc003xgr.2_Missense_Mutation_p.H253Y|ZNF395_uc003xgs.2_Missense_Mutation_p.H253Y	NM_018660	NP_061130	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	253					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		TCAAAGCCATGATCAGTTTGG	0.587													0	0	0	0.045705	0	23	21										A	28210752	G	A	28210752	3	1	115	1	0	0	0	0	1	0	0	0	17878	1290	45	1	808	1	ZNF395	8	28210752	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		28210752	118153270	37	34575										
ENPP2	5168	broad.mit.edu	37	chr8	120598469	120598469	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	caccaataaatggatatcctCaattcttctgttgttggcat	6	9	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr8:120598469C>G	uc003yot.1	-	15	1410	c.1324G>C	c.(1324-1326)GAG>CAG	p.E442Q	ENPP2_uc011lic.1_5'Flank|ENPP2_uc003yor.1_Missense_Mutation_p.E81Q|ENPP2_uc003yos.1_Missense_Mutation_p.E494Q|ENPP2_uc010mdd.1_Missense_Mutation_p.E442Q	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	442					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGGATATCCTCAATTCTTCTG	0.413													0	0	0	0.108266	0	25	60										G	120598469	C	G	120598469	3	3	115	1	0	0	0	0	1	0	0	0	5130	835	29	1	1390	1	ENPP2	8	120598469	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	92387717	120598469	25765553	38	34576										
KIAA0368	23392	broad.mit.edu	37	chr9	114206748	114206748	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gggcggctttttatacgtttAttcagatggaccagcagttc	11	8	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:114206748A>C	uc004bfe.1	-	5	714	c.714T>G	c.(712-714)AAT>AAG	p.N238K	KIAA0368_uc010muc.1_Missense_Mutation_p.N60K	NM_001080398	NP_001073867			KIAA0368 protein												0						TTATACGTTTATTCAGATGGA	0.388													0	0	0	0.080935	0	9	35										C	114206748	A	C	114206748	3	2	115	1	0	0	0	0	1	0	0	0	8171	446	16	5	5527	5	KIAA0368	9	114206748	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08		114206748	27006683	39	34577										
C5	727	broad.mit.edu	37	chr9	123742496	123742496	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tggcagtgtattttcaagcaGaaagttgtcagctttaatta	9	5	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:123742496G>T	uc004bkv.2	-	28	3553	c.3523C>A	c.(3523-3525)CTG>ATG	p.L1175M		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1175					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TTTTCAAGCAGAAAGTTGTCA	0.408													1	0	1.04858e-14	0.058154	1.16417e-14	7	50										T	123742496	G	T	123742496	3	4	115	1	0	0	0	0	1	0	0	0	2280	933	33	3	1563	3	C5	9	123742496	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	9535748	123742496	17470935	40	34578										
ZNF79	7633	broad.mit.edu	37	chr9	130207140	130207140	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aggactcacactggggagaaAccctacaagtgcagcgagtg	13	10	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:130207140A>G	uc004bqw.3	+	5	1575	c.1161A>G	c.(1159-1161)AAA>AAG	p.K387K	ZNF79_uc011maf.1_Silent_p.K363K|ZNF79_uc011mag.1_Silent_p.K363K	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CTGGGGAGAAACCCTACAAGT	0.532													0	0	0	0.02938	0	3	72										G	130207140	A	G	130207140	2	3	115	1	0	0	0	0	0	0	0	1	18158	40	2	5		5	ZNF79	9	130207140	Silent	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	6464644	130207140	11006291	41	34579										
C9orf119	375757	broad.mit.edu	37	chr9	131038427	131038427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gcggaagggggcgtggctatGcagcggcgtggccagaggga	22	8	0	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:131038427G>A	uc004bup.2	+	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I	GOLGA2_uc011maw.1_5'Flank|GOLGA2_uc010mxw.2_5'Flank|GOLGA2_uc004bul.1_5'Flank|C9orf119_uc010mxx.1_Missense_Mutation_p.M1I	NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	1					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						GCGTGGCTATGCAGCGGCGTG	0.627													0	0	0	0.139131	0	45	57										A	131038427	G	A	131038427	3	1	115	1	0	0	0	0	1	0	0	0	2452	1319	46	2	5	2	C9orf119	9	131038427	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	831287	131038427	10175004	42	34580										
WDR34	89891	broad.mit.edu	37	chr9	131397988	131397988	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gtcaggcctgtgcgccacagCagcgggtcctcaagacggct	14	14	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr9:131397988C>A	uc004bvq.1	-	5	886	c.762G>T	c.(760-762)CTG>CTT	p.L254L	WDR34_uc004bvs.1_Silent_p.L245L|WDR34_uc004bvr.1_Silent_p.L254L	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	254	WD 1.					cytoplasm				central_nervous_system(2)|skin(1)	3						TGCGCCACAGCAGCGGGTCCT	0.692													1	0	0.00909568	0.009096	0.00949993	3	38										A	131397988	C	A	131397988	2	1	115	1	0	0	0	0	0	0	0	1	17285	697	25	4		4	WDR34	9	131397988	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	359561	131397988	9815443	43	34581										
KIF11	3832	broad.mit.edu	37	chr10	94405356	94405356	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tttttctgaacagtgggtatCttccttaaatgaaagggaac	9	6	2	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:94405356C>G	uc001kic.2	+	18	2812	c.2504C>G	c.(2503-2505)TCT>TGT	p.S835C	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	835					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						CAGTGGGTATCTTCCTTAAAT	0.343													0	0	0	0.0333	0	14	20										G	94405356	C	G	94405356	3	3	115	1	0	0	0	0	1	0	0	0	8272	913	32	1	2574	1	KIF11	10	94405356	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		94405356	41129391	44	34582										
PGAM1	5223	broad.mit.edu	37	chr10	99190742	99190742	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	atgcagacctcacagaagatCagctaccctcctgtgagagt	9	12	2	4			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:99190742C>G	uc001knh.2	+	3	483	c.445C>G	c.(445-447)CAG>GAG	p.Q149E	PGAM1_uc009xvo.2_Intron|PGAM1_uc010qov.1_Missense_Mutation_p.Q134E	NM_002629	NP_002620	P18669	PGAM1_HUMAN	phosphoglycerate mutase 1	149					gluconeogenesis|glycolysis|regulation of glycolysis|regulation of pentose-phosphate shunt|respiratory burst	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|protein kinase binding				0		Colorectal(252;0.162)		Epithelial(162;8.36e-10)|all cancers(201;5.62e-08)		CACAGAAGATCAGCTACCCTC	0.433													0	0	0	0.0918	0	15	28										G	99190742	C	G	99190742	3	3	115	1	0	0	0	0	1	0	0	0	11773	827	29	1	455	1	PGAM1	10	99190742	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	4785386	99190742	36344005	45	34583										
SEC23IP	11196	broad.mit.edu	37	chr10	121663630	121663630	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gagagcgtggttcttggcacGgatggagggcgctacgatgt	18	7	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr10:121663630G>A	uc001leu.1	+	4	1014	c.942G>A	c.(940-942)ACG>ACA	p.T314T	SEC23IP_uc010qtc.1_Silent_p.T103T	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	314	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TTCTTGGCACGGATGGAGGGC	0.453													0	0	0	0.014758	0	4	53										A	121663630	G	A	121663630	2	1	115	1	0	0	0	0	0	0	0	1	13993	1103	39	2		2	SEC23IP	10	121663630	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	22472888	121663630	13871117	46	34584										
NUP98	4928	broad.mit.edu	37	chr11	3794864	3794864	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gtattgtattttactgacctCtagtgacttgctttcatatt	6	7	2	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:3794864C>G	uc001lyh.2	-	6	892	c.601G>C	c.(601-603)GAG>CAG	p.E201Q	NUP98_uc001lyi.2_Missense_Mutation_p.E201Q|NUP98_uc001lyj.1_Missense_Mutation_p.E201Q|NUP98_uc001lyk.1_Missense_Mutation_p.E201Q|NUP98_uc010qxv.1_Missense_Mutation_p.E164Q	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	201	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TTACTGACCTCTAGTGACTTG	0.343			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.105934	0	11	8										G	3794864	C	G	3794864	3	3	115	1	0	0	0	0	1	0	0	0	10773	922	32	1	4985	1	NUP98	11	3794864	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		3794864	131211652	47	34585										
OR52B6	340980	broad.mit.edu	37	chr11	5602231	5602231	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tggcatccctgggctggagcAactacatatctggctgtcca	11	12	1	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:5602231A>C	uc010qzi.1	+	1	125	c.125A>C	c.(124-126)CAA>CCA	p.Q42P	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	42	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGCTGGAGCAACTACATATC	0.502													0	0	0	0.038147	0	7	12										C	5602231	A	C	5602231	3	2	115	1	0	0	0	0	1	0	0	0	11113	130	5	5	127	5	OR52B6	11	5602231	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	1807367	5602231	129404285	48	34586										
OR5A2	219981	broad.mit.edu	37	chr11	59189895	59189895	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tggagggaggtcacagaaaaAgtggttgatcatatagggcc	15	5	2	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:59189895A>C	uc010rkt.1	-	1	532	c.532T>G	c.(532-534)TTT>GTT	p.F178V		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCACAGAAAAAGTGGTTGATC	0.483													0	0	0	0.009096	0	3	65										C	59189895	A	C	59189895	3	2	115	1	0	0	0	0	1	0	0	0	11140	72	3	5	444	5	OR5A2	11	59189895	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	53587664	59189895	75816621	49	34587										
OR6X1	390260	broad.mit.edu	37	chr11	123624493	123624493	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ccccgtagagcagggagacaActgtcaggtgcgaggcacag	15	11	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:123624493A>G	uc010rzy.1	-	1	734	c.734T>C	c.(733-735)GTT>GCT	p.V245A		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CAGGGAGACAACTGTCAGGTG	0.453													0	0	0	0.09319	0	13	22										G	123624493	A	G	123624493	3	3	115	1	0	0	0	0	1	0	0	0	11212	43	2	5	206	5	OR6X1	11	123624493	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	64434598	123624493	11382023	50	34588										
SLC37A2	219855	broad.mit.edu	37	chr11	124952197	124952197	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agctggtcagttacaccttcCtctactggctgcccctctac	7	16	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr11:124952197C>A	uc001qbn.2	+	10	1194	c.943C>A	c.(943-945)CTC>ATC	p.L315I	SLC37A2_uc010sau.1_Missense_Mutation_p.L315I|SLC37A2_uc010sav.1_5'Flank|SLC37A2_uc001qbp.2_5'Flank	NM_001145290	NP_001138762	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glycerol-3-phosphate	315	Helical; (Potential).				carbohydrate transport|transmembrane transport	integral to membrane				ovary(2)	2	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		TTACACCTTCCTCTACTGGCT	0.587													1	0	9.45814e-24	0.074837	1.06688e-23	30	48										A	124952197	C	A	124952197	3	1	115	1	0	0	0	0	1	0	0	0	14598	681	24	4	981	4	SLC37A2	11	124952197	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	1327704	124952197	10054319	51	34589										
BCL2L14	79370	broad.mit.edu	37	chr12	12232321	12232321	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ccatagaattcaaaatcctcGcctactacaccagacatcat	3	14	2	2	rs142096906	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:12232321G>A	uc001rac.2	+	2	283	c.82G>A	c.(82-84)GCC>ACC	p.A28T	ETV6_uc001raa.1_Intron|BCL2L14_uc001raf.1_RNA|BCL2L14_uc001rad.2_Missense_Mutation_p.A28T|BCL2L14_uc001rae.2_Missense_Mutation_p.A28T	NM_138723	NP_620049	Q9BZR8	B2L14_HUMAN	BCL2-like 14 isoform 1	28					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			skin(1)	1		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CAAAATCCTCGCCTACTACAC	0.488													0	0	0	0.083992	0	22	29										A	12232321	G	A	12232321	3	1	115	1	0	0	0	0	1	0	0	0	1372	1087	38	2	84	2	BCL2L14	12	12232321	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		12232321	121619574	52	34590										
PAN2	9924	broad.mit.edu	37	chr12	56716212	56716212	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	catgttgcaactaaccttatCaataggttcaataagaaagt	6	7	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr12:56716212C>T	uc001skx.2	-	19	3077	c.2704G>A	c.(2704-2706)GAT>AAT	p.D902N	PAN2_uc001skw.2_Missense_Mutation_p.D50N|PAN2_uc001skz.2_Missense_Mutation_p.D901N|PAN2_uc001sky.2_Missense_Mutation_p.D898N	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	902					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CTAACCTTATCAATAGGTTCA	0.408													0	0	0	0.132662	0	12	42										T	56716212	C	T	56716212	3	4	115	1	0	0	0	0	1	0	0	0	11414	826	29	1	936	1	PAN2	12	56716212	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	44483891	56716212	77135683	53	34591										
MTMR6	9107	broad.mit.edu	37	chr13	25840079	25840079	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aagttctctggggtaagtttCacaaatctgtaaatatcaaa	7	6	4	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:25840079C>T	uc001uqf.3	-	5	788	c.469G>A	c.(469-471)GAA>AAA	p.E157K	MTMR6_uc001uqe.1_Missense_Mutation_p.E157K	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	157	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		GGGTAAGTTTCACAAATCTGT	0.353													0	0	0	0.09319	0	11	17										T	25840079	C	T	25840079	3	4	115	1	0	0	0	0	1	0	0	0	9947	835	29	1	1436	1	MTMR6	13	25840079	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		25840079	89329799	54	34592										
AKAP11	11215	broad.mit.edu	37	chr13	42876628	42876628	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gcctacttttttaaacccctCagacgaaaatttgaaaacat	4	10	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:42876628C>G	uc001uys.1	+	8	3921	c.3746C>G	c.(3745-3747)TCA>TGA	p.S1249*		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1249					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTAAACCCCTCAGACGAAAAT	0.363													0	0	0	0.038395	0	16	5										G	42876628	C	G	42876628	4	3	115	1	0	0	0	0	0	1	0	0	447	838	29	1	3768	1	AKAP11	13	42876628	Nonsense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	17036549	42876628	72293250	55	34593										
IRS2	8660	broad.mit.edu	37	chr13	110436504	110436504	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggagccgatctcgatgtctcCgtagtcctctgggtaggggt	15	10	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr13:110436504C>T	uc001vqv.2	-	1	2411	c.1897G>A	c.(1897-1899)GGA>AGA	p.G633R		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	633					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TCGATGTCTCCGTAGTCCTCT	0.711													0	0	0	0.047766	0	5	5										T	110436504	C	T	110436504	3	4	115	1	0	0	0	0	1	0	0	0	7841	661	23	2	2127	2	IRS2	13	110436504	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	67559876	110436504	4733374	56	34594										
HOMEZ	57594	broad.mit.edu	37	chr14	23746018	23746018	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gtcccgcatgatgagtaaaaGagagaagggatttgaaatgg	14	4	0	5			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:23746018G>T	uc001wja.2	-	2	567	c.419C>A	c.(418-420)TCT>TAT	p.S140Y	HOMEZ_uc001wjb.2_Missense_Mutation_p.S142Y	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	140						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ATGAGTAAAAGAGAGAAGGGA	0.537													1	0	1.58521e-26	0.080422	1.80253e-26	34	89										T	23746018	G	T	23746018	3	4	115	1	0	0	0	0	1	0	0	0	7281	942	33	3	1237	3	HOMEZ	14	23746018	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		23746018	83603522	57	34595										
TGM1	7051	broad.mit.edu	37	chr14	24731538	24731538	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ccaccccaacggcccacatcGgaacgtggcccatccatcat	7	19	1	0	rs150913268	by1000genomes	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:24731538G>A	uc001wod.2	-	2	145	c.21C>T	c.(19-21)TCC>TCT	p.S7S	TGM1_uc010tog.1_5'UTR	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	7	Membrane anchorage region.				cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGCCCACATCGGAACGTGGCC	0.632													0	0	0	0.146539	0	15	47										A	24731538	G	A	24731538	2	1	115	1	0	0	0	0	0	0	0	1	15826	1103	39	2		2	TGM1	14	24731538	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	985520	24731538	82618002	58	34596										
GNPNAT1	64841	broad.mit.edu	37	chr14	53251332	53251332	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ccagtccacttctttgagtaGacttgggtcaaacataggag	10	9	2	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:53251332G>C	uc001xab.2	-	2	292	c.37C>G	c.(37-39)CTA>GTA	p.L13V		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	13					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					TCTTTGAGTAGACTTGGGTCA	0.363													0	0	0	0.038395	0	13	18										C	53251332	G	C	53251332	3	2	115	1	0	0	0	0	1	0	0	0	6544	933	33	1	537	1	GNPNAT1	14	53251332	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	28519794	53251332	54098208	59	34597										
SMOC1	64093	broad.mit.edu	37	chr14	70418941	70418941	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tgtgcctctgatggcaggtcCtacgagtccatgtgtgagta	13	9	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:70418941C>A	uc001xls.1	+	2	439	c.186C>A	c.(184-186)TCC>TCA	p.S62S	SMOC1_uc001xlt.1_Silent_p.S62S	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	62	Kazal-like.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATGGCAGGTCCTACGAGTCCA	0.562													1	0	9.62906e-15	0.086207	1.07754e-14	32	75										A	70418941	C	A	70418941	2	1	115	1	0	0	0	0	0	0	0	1	14801	668	24	4		4	SMOC1	14	70418941	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	17167609	70418941	36930599	60	34598										
ADAM20	8748	broad.mit.edu	37	chr14	70991613	70991613	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tggggatctgtgtcctggtgGagctggaccatcagagctgc	16	9	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:70991613G>A	uc001xme.2	-	2	257	c.12C>T	c.(10-12)CTC>CTT	p.L4L		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	Error:Variant_position_missing_in_O43506_after_alignment					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TGTCCTGGTGGAGCTGGACCA	0.522													0	0	0	0.139131	0	67	46										A	70991613	G	A	70991613	2	1	115	1	0	0	0	0	0	0	0	1	242	1161	41	1		1	ADAM20	14	70991613	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	572672	70991613	36357927	61	34599										
MTA1	9112	broad.mit.edu	37	chr14	105936438	105936438	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ctctcatcctcggaaaccaaGcgtgctgcccgccggcccta	9	18	1	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr14:105936438G>C	uc001yqx.2	+	21	2221	c.2034G>C	c.(2032-2034)AAG>AAC	p.K678N	MTA1_uc001yqy.2_RNA|MTA1_uc001yrb.2_Missense_Mutation_p.K443N|CRIP2_uc010tyr.1_5'Flank|CRIP2_uc001yrc.2_5'Flank	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	678					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		CGGAAACCAAGCGTGCTGCCC	0.716													0	0	0	0.116897	0	21	48										C	105936438	G	C	105936438	3	2	115	1	0	0	0	0	1	0	0	0	9908	962	34	4	2116	4	MTA1	14	105936438	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	34944825	105936438	1413102	62	34600										
HERC2	8924	broad.mit.edu	37	chr15	28458889	28458889	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	taagcacaagttcacctactGgtttcagctgattcaatggg	9	9	3	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr15:28458889G>A	uc001zbj.2	-	42	6891	c.6785C>T	c.(6784-6786)CCA>CTA	p.P2262L		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2262					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TTCACCTACTGGTTTCAGCTG	0.478													0	0	0	0.146539	0	14	22										A	28458889	G	A	28458889	3	1	115	1	0	0	0	0	1	0	0	0	7058	1362	47	2	7927	2	HERC2	15	28458889	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		28458889	74072503	63	34601										
MYO5A	4644	broad.mit.edu	37	chr15	52632551	52632551	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gagggcctcggcctcattctCatggctcctcttctgtgact	10	14	4	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr15:52632551C>T	uc002aby.2	-	32	4325	c.4081G>A	c.(4081-4083)GAG>AAG	p.E1361K	MYO5A_uc002abx.3_Missense_Mutation_p.E1334K|MYO5A_uc010ugd.1_Missense_Mutation_p.E83K|MYO5A_uc002abz.1_RNA|MYO5A_uc002aca.1_Missense_Mutation_p.E113K|MYO5A_uc002acb.1_Missense_Mutation_p.E86K|MYO5A_uc002acc.1_Missense_Mutation_p.E110K	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1361	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GCCTCATTCTCATGGCTCCTC	0.632													0	0	0	0.139131	0	55	411										T	52632551	C	T	52632551	3	4	115	1	0	0	0	0	1	0	0	0	10078	835	29	1	1526	1	MYO5A	15	52632551	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	24173662	52632551	49898841	64	34602										
CACNG3	10368	broad.mit.edu	37	chr16	24268126	24268126	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ttgatcaccactgtaggagcCtttgccgcttttagtttaat	8	9	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:24268126C>T	uc002dmf.2	+	1	1251	c.51C>T	c.(49-51)GCC>GCT	p.A17A		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	17	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CTGTAGGAGCCTTTGCCGCTT	0.473													0	0	0	0.043863	0	17	801										T	24268126	C	T	24268126	2	4	115	1	0	0	0	0	0	0	0	1	2558	668	24	2		2	CACNG3	16	24268126	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		24268126	66086627	65	34603										
SEZ6L2	26470	broad.mit.edu	37	chr16	29883848	29883848	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tggatctgtggtctgggtcaCtacaggaggaggagaggccg	18	7	3	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:29883848C>G	uc002duq.3	-	15	2729	c.2489_splice	c.e15-1	p.V830_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Splice_Site_p.V773_splice|SEZ6L2_uc002dur.3_Splice_Site_p.V760_splice|SEZ6L2_uc002dus.3_Splice_Site_p.V729_splice|SEZ6L2_uc010vec.1_Splice_Site_p.V843_splice|SEZ6L2_uc010ved.1_Splice_Site_p.V799_splice	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GTCTGGGTCACTACAGGAGGA	0.657													0	0	0	0.062417	0	15	64										G	29883848	C	G	29883848	5	3	115	1	0	0	0	0	0	0	1	0	14144	579	20	4	256	4	SEZ6L2	16	29883848	Splice_Site	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	5615722	29883848	60470905	66	34604										
DOC2A	8448	broad.mit.edu	37	chr16	30018508	30018508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	acagaccgggacctggcgctCgaggcagatgttaaaatgct	13	10	0	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30018508C>T	uc002dvm.2	-	6	740	c.640G>A	c.(640-642)GAG>AAG	p.E214K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Missense_Mutation_p.E214K|DOC2A_uc002dvn.2_Missense_Mutation_p.E214K|DOC2A_uc010vef.1_RNA|DOC2A_uc002dvo.2_Missense_Mutation_p.E214K|DOC2A_uc002dvp.2_Missense_Mutation_p.E214K|DOC2A_uc002dvq.2_Missense_Mutation_p.E214K	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	214					nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						ACCTGGCGCTCGAGGCAGATG	0.627													0	0	0	0.09319	0	9	229										T	30018508	C	T	30018508	3	4	115	1	0	0	0	0	1	0	0	0	4683	893	31	1	586	1	DOC2A	16	30018508	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	134660	30018508	60336245	67	34605										
ZNF768	79724	broad.mit.edu	37	chr16	30536523	30536523	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gacatttgtagggccgctcgCcagtgtgggtgcgctggtgt	17	9	0	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30536523C>T	uc002dyk.3	-	2	1114	c.938G>A	c.(937-939)GGC>GAC	p.G313D	ZNF768_uc010vex.1_Missense_Mutation_p.G282D|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.G282D	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	313					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GGGCCGCTCGCCAGTGTGGGT	0.607													0	0	0	0.038395	0	14	49										T	30536523	C	T	30536523	3	4	115	1	0	0	0	0	1	0	0	0	18138	739	26	2	688	2	ZNF768	16	30536523	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	518015	30536523	59818230	68	34606			2	160		4	4	9362	N	G_C	3.988203e-06
ZNF768	79724	broad.mit.edu	37	chr16	30537018	30537018	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cagtgttctgggattcatatCtagagctctcagattcatag	9	8	5	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30537018C>A	uc002dyk.3	-	2	619	c.443G>T	c.(442-444)AGA>ATA	p.R148I	ZNF768_uc010vex.1_Missense_Mutation_p.R117I|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.R117I	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	148					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GGATTCATATCTAGAGCTCTC	0.527													1	0	8.10497e-08	0.055883	8.72367e-08	22	77										A	30537018	C	A	30537018	3	1	115	1	0	0	0	0	1	0	0	0	18138	913	32	3	1183	3	ZNF768	16	30537018	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	495	30537018	59817735	69	34607			2	160		4	4	9362	N	G_C	3.988203e-06
ZNF768	79724	broad.mit.edu	37	chr16	30537349	30537349	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ttcttgctgagaaatttcctCttcctcattctcactcatgt	4	12	5	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30537349C>T	uc002dyk.3	-	2	288	c.112G>A	c.(112-114)GAG>AAG	p.E38K	ZNF768_uc010vex.1_Missense_Mutation_p.E7K|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.E7K	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	38	Poly-Glu.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						gaaatttcctctTCCTCATTC	0.408													0	0	0	0.080422	0	29	139										T	30537349	C	T	30537349	3	4	115	1	0	0	0	0	1	0	0	0	18138	922	32	1	1514	1	ZNF768	16	30537349	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	331	30537349	59817404	70	34608			2	160		4	4	9362	N	G_C	3.988203e-06
ZNF747	65988	broad.mit.edu	37	chr16	30545884	30545884	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aagtacacggccacgtcggcGaagctcacggccccgggctt	13	15	1	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:30545884G>A	uc002dyn.2	-	1	311	c.117C>T	c.(115-117)TTC>TTT	p.F39F	ZNF768_uc010vex.1_5'UTR|ZNF747_uc002dyo.1_Silent_p.F39F|ZNF747_uc010vey.1_Silent_p.F39F|uc002dyp.1_5'Flank	NM_023931	NP_076420	Q9BV97	ZN747_HUMAN	zinc finger protein 747	39	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0						CCACGTCGGCGAAGCTCACGG	0.731													0	0	0	0.047766	0	5	10										A	30545884	G	A	30545884	2	1	115	1	0	0	0	0	0	0	0	1	18127	1049	37	1		1	ZNF747	16	30545884	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	8535	30545884	59808869	71	34609			2	160		4	4	9362	N	G_C	3.988203e-06
ABCC11	85320	broad.mit.edu	37	chr16	48234386	48234387	+	Nonsense_Mutation	DNP	CC	CC	TA													0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agaggttgaggccccgctctCcaatctgcagacaggcagta							TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:48234386_48234387CC>TA	uc002eff.1	-	14	2232_2233	c.1882_1883GG>TA	c.(1882-1884)GGA>TAA	p.G628*	ABCC11_uc002efg.1_Nonsense_Mutation_p.G628*|ABCC11_uc002efh.1_Nonsense_Mutation_p.G628*|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	628	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCCCCGCTCTCCAATCTGCAGA	0.594									Cerumen_Type				0	0	0	0.115264	0	6	47										TA	48234387	CC	TA	48234386	4	4	115	1	0	0	0	0	0	1	0	0	51	855	30	1	2329	1	ABCC11	16	48234386	Nonsense_Mutation	DNP	CC	TCGA-GV-A3JW-01A-11D-A20D-08	17688502	48234386	42120367	72	34610										
CDH13	1012	broad.mit.edu	37	chr16	83711918	83711918	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gccccagctccacagccaccGtccacatcactgtcctggat	7	19	1	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr16:83711918G>A	uc002fgx.2	+	10	1510	c.1390G>A	c.(1390-1392)GTC>ATC	p.V464I	CDH13_uc010vns.1_Missense_Mutation_p.V511I|CDH13_uc010vnt.1_Missense_Mutation_p.V210I|CDH13_uc010vnu.1_Missense_Mutation_p.V425I	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	464	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		CACAGCCACCGTCCACATCAC	0.577													0	0	0	0.132662	0	13	69										A	83711918	G	A	83711918	3	1	115	1	0	0	0	0	1	0	0	0	3099	1145	40	2	1428	2	CDH13	16	83711918	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	35477532	83711918	6642835	73	34611										
SGSM2	9905	broad.mit.edu	37	chr17	2279473	2279473	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ccttaaacctgcaccgcataGacaaggatgtgcagaggtgt	11	10	0	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:2279473G>A	uc002fun.3	+	18	2567	c.2392G>A	c.(2392-2394)GAC>AAC	p.D798N	SGSM2_uc002fum.3_Missense_Mutation_p.D843N|SGSM2_uc010vqw.1_Missense_Mutation_p.D798N|SGSM2_uc002fup.1_5'UTR|SGSM2_uc002fuq.2_5'Flank	NM_001098509	NP_001091979	O43147	SGSM2_HUMAN	RUN and TBC1 domain containing 1 isoform 2	798	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GCACCGCATAGACAAGGATGT	0.607													0	0	0	0.043863	0	15	76										A	2279473	G	A	2279473	3	1	115	1	0	0	0	0	1	0	0	0	14223	942	33	1	2601	1	SGSM2	17	2279473	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		2279473	78915737	74	34612										
PLD2	5338	broad.mit.edu	37	chr17	4718857	4718857	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggctatagcaagagggcgctGatgctgctgcaccccaacat	12	12	0	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:4718857G>A	uc002fzc.2	+	13	1361	c.1260G>A	c.(1258-1260)CTG>CTA	p.L420L	PLD2_uc010vsj.1_Silent_p.L277L|PLD2_uc002fzd.2_Silent_p.L420L	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	420					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	AGAGGGCGCTGATGCTGCTGC	0.577											OREG0024105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	47	165										A	4718857	G	A	4718857	2	1	115	1	0	0	0	0	0	0	0	1	12046	1277	45	1		1	PLD2	17	4718857	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	2439384	4718857	76476353	75	34613										
RPAIN	84268	broad.mit.edu	37	chr17	5331461	5331461	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aaatgagcacagtgcacattGtccccacacacctgaatttt	6	12	0	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:5331461G>T	uc002gbq.2	+	6	1130	c.560G>T	c.(559-561)TGT>TTT	p.C187F	RPAIN_uc010vsz.1_Missense_Mutation_p.C187F|RPAIN_uc002gbp.1_Missense_Mutation_p.C203F|RPAIN_uc010vta.1_3'UTR|RPAIN_uc010vtb.1_Intron|RPAIN_uc002gbs.2_Missense_Mutation_p.C203F|RPAIN_uc002gbt.2_Intron|RPAIN_uc002gbu.2_Intron|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Intron|RPAIN_uc002gbx.1_5'Flank	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	187	RIP-type.				DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						AGTGCACATTGTCCCCACACA	0.463													1	0	6.3237e-29	0.139131	7.24912e-29	48	53										T	5331461	G	T	5331461	3	4	115	1	0	0	0	0	1	0	0	0	13540	1377	48	4	582	4	RPAIN	17	5331461	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	612604	5331461	75863749	76	34614										
TP53	7157	broad.mit.edu	37	chr17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	actgcttgtagatggccatgGcgcggacgcgggtgccgggc	18	11	0	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:7578454G>A	uc002gim.2	-	5	670	c.476C>T	c.(475-477)GCC>GTC	p.A159V	TP53_uc002gig.1_Missense_Mutation_p.A159V|TP53_uc002gih.2_Missense_Mutation_p.A159V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27V|TP53_uc010cng.1_Missense_Mutation_p.A27V|TP53_uc002gii.1_Missense_Mutation_p.A27V|TP53_uc010cnh.1_Missense_Mutation_p.A159V|TP53_uc010cni.1_Missense_Mutation_p.A159V|TP53_uc002gij.2_Missense_Mutation_p.A159V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66V|TP53_uc002gio.2_Missense_Mutation_p.A27V|TP53_uc010vug.1_Missense_Mutation_p.A120V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.139131	0	48	8										A	7578454	G	A	7578454	3	1	115	1	0	0	0	0	1	0	0	0	16378	1203	42	2	822	2	TP53	17	7578454	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	2246993	7578454	73616756	77	34615										
FLII	2314	broad.mit.edu	37	chr17	18155374	18155374	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agccgcagctggttctgcagCgagaagtcgatgttgtacca	13	10	1	1	rs145214604		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:18155374C>T	uc002gsr.1	-	11	1236	c.1185G>A	c.(1183-1185)TCG>TCA	p.S395S	FLII_uc002gsq.1_Silent_p.S267S|FLII_uc010cpy.1_Silent_p.S384S|FLII_uc010vxn.1_Silent_p.S364S|FLII_uc010vxo.1_Silent_p.S341S|FLII_uc002gss.1_Silent_p.S395S	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	395	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GGTTCTGCAGCGAGAAGTCGA	0.652													0	0	0	0.139131	0	43	43										T	18155374	C	T	18155374	2	4	115	1	0	0	0	0	0	0	0	1	5925	755	27	2		2	FLII	17	18155374	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	10576920	18155374	63039836	78	34616										
SLFN13	146857	broad.mit.edu	37	chr17	33769022	33769022	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	atgttcactagcttctgcttCaaagtaaaggcggtgcgagt	11	8	3	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:33769022C>T	uc002hjk.1	-	3	1812	c.1482G>A	c.(1480-1482)TTG>TTA	p.L494L	SLFN13_uc010wch.1_Silent_p.L494L|SLFN13_uc002hjl.2_Silent_p.L494L|SLFN13_uc010ctt.2_Silent_p.L176L|SLFN13_uc002hjm.2_Silent_p.L163L	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	494						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GCTTCTGCTTCAAAGTAAAGG	0.582													0	0	0	0.069234	0	5	67										T	33769022	C	T	33769022	2	4	115	1	0	0	0	0	0	0	0	1	14736	825	29	1		1	SLFN13	17	33769022	Silent	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	15613648	33769022	47426188	79	34617										
ITGA3	3675	broad.mit.edu	37	chr17	48155574	48155574	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ctgcatttcctcccaaggtcGagtcaccaggacaacctgtg	9	14	1	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:48155574G>A	uc010dbl.2	+	18	2687	c.2223G>A	c.(2221-2223)TCG>TCA	p.S741S	ITGA3_uc010dbm.2_Silent_p.S741S	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	741	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						TCCCAAGGTCGAGTCACCAGG	0.572													0	0	0	0.021553	0	5	87										A	48155574	G	A	48155574	2	1	115	1	0	0	0	0	0	0	0	1	7877	1045	37	1		1	ITGA3	17	48155574	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	14386552	48155574	33039636	80	34618										
TEX2	55852	broad.mit.edu	37	chr17	62230483	62230483	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aattttatcaacaaacctcaTaatcttacttgttcgatgac	3	9	3	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:62230483T>G	uc002jec.2	-	10	3135	c.2962A>C	c.(2962-2964)ATG>CTG	p.M988L	TEX2_uc002jed.2_Missense_Mutation_p.M995L|TEX2_uc002jee.2_Missense_Mutation_p.M988L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	988					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		ACAAACCTCATAATCTTACTT	0.383													0	0	0	0.038147	0	6	31										G	62230483	T	G	62230483	3	3	115	1	0	0	0	0	1	0	0	0	15778	1406	49	5	433	5	TEX2	17	62230483	Missense_Mutation	SNP	T	TCGA-GV-A3JW-01A-11D-A20D-08	14074909	62230483	18964727	81	34619										
BPTF	2186	broad.mit.edu	37	chr17	65941562	65941562	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cagagtaaactgtcaccccaGatgcaggtacatcaagacaa	8	11	2	3			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:65941562G>A	uc002jgf.2	+	21	6799	c.6738G>A	c.(6736-6738)CAG>CAA	p.Q2246Q	BPTF_uc002jge.2_Silent_p.Q2372Q|BPTF_uc002jgg.2_Silent_p.Q46Q|BPTF_uc002jgh.2_5'Flank	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2372					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTCACCCCAGATGCAGGTAC	0.448													0	0	0	0.064281	0	27	58										A	65941562	G	A	65941562	2	1	115	1	0	0	0	0	0	0	0	1	1495	933	33	1		1	BPTF	17	65941562	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	3711079	65941562	15253648	82	34620										
UTS2R	2837	broad.mit.edu	37	chr17	80333364	80333364	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cccgagggtcccagggccccGgcgtgagcacgcggaggggc	19	15	0	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr17:80333364G>A	uc010wvl.1	+	1	1164	c.1164G>A	c.(1162-1164)CCG>CCA	p.P388P		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	urotensin 2 receptor	388	Cytoplasmic (Potential).					integral to membrane|plasma membrane				breast(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			CCAGGGCCCCGGCGTGAGCAC	0.761													0	0	0	0.021553	0	5	8										A	80333364	G	A	80333364	2	1	115	1	0	0	0	0	0	0	0	1	17103	1103	39	2		2	UTS2R	17	80333364	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	14391802	80333364	861846	83	34621										
RAB12	201475	broad.mit.edu	37	chr18	8624998	8624998	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	aaattagattacagatctggTaagtgggagagtgtgcaccc	12	6	1	3			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr18:8624998T>C	uc002knp.2	+	2	570	c.287_splice	c.e2+2	p.W96_splice		NM_001025300	NP_001020471	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0						ACAGATCTGGTAAGTGGGAGA	0.358													0	0	0	0.139131	0	45	96										C	8624998	T	C	8624998	5	2	115	1	0	0	0	0	0	0	1	0	12898	1652	57	5	295	5	RAB12	18	8624998	Splice_Site	SNP	T	TCGA-GV-A3JW-01A-11D-A20D-08		8624998	69452250	84	34622										
ICAM5	7087	broad.mit.edu	37	chr19	10402342	10402342	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cggtgaaccaccccgagcgcGgggcgcggtgctcacagcca	15	16	1	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:10402342G>A	uc002mnu.3	+	3	595	c.530G>A	c.(529-531)CGG>CAG	p.R177Q	ICAM5_uc002mnv.3_Missense_Mutation_p.R52Q	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	177	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CCCCGAGCGCGGGGCGCGGTG	0.736													0	0	0	0.080935	0	7	23										A	10402342	G	A	10402342	3	1	115	1	0	0	0	0	1	0	0	0	7483	1116	39	2	540	2	ICAM5	19	10402342	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08		10402342	48726641	85	34623										
ZNF878	729747	broad.mit.edu	37	chr19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ctacgaacagaactgggaaaActgaatgctttcccacactg	8	11	0	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:12155673A>C	uc002mta.1	-	5	684	c.684T>G	c.(682-684)AGT>AGG	p.S228R		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	181	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AACTGGGAAAACTGAATGCTT	0.403													0	0	0	0.021553	0	4	158										C	12155673	A	C	12155673	3	2	115	1	0	0	0	0	1	0	0	0	18193	40	2	5	1056	5	ZNF878	19	12155673	Missense_Mutation	SNP	A	TCGA-GV-A3JW-01A-11D-A20D-08	1753331	12155673	46973310	86	34624										
KLHL26	55295	broad.mit.edu	37	chr19	18778894	18778894	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gagatcgacctgttccgcgcGgccgtccgctggctgcagca	14	15	0	1	rs150852328	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:18778894G>A	uc002njz.1	+	3	714	c.687G>A	c.(685-687)GCG>GCA	p.A229A		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	229	BACK.									ovary(1)	1						TGTTCCGCGCGGCCGTCCGCT	0.582													0	0	0	0.11911	0	14	22										A	18778894	G	A	18778894	2	1	115	1	0	0	0	0	0	0	0	1	8381	1103	39	2		2	KLHL26	19	18778894	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	6623221	18778894	40350089	87	34625										
SLC8A2	6543	broad.mit.edu	37	chr19	47935695	47935695	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gacccgtcctcctcctcctcCtcgtcccctgtgggcacacg	8	21	0	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:47935695C>G	uc002pgx.2	-	9	2396	c.2118G>C	c.(2116-2118)GAG>GAC	p.E706D	SLC8A2_uc010xyq.1_Missense_Mutation_p.E462D|SLC8A2_uc010xyr.1_Missense_Mutation_p.E169D|SLC8A2_uc010ele.2_Missense_Mutation_p.E706D	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	706	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCTCCTCCTCCTCGTCCCCTG	0.602													0	0	0	0.021553	0	5	144										G	47935695	C	G	47935695	3	3	115	1	0	0	0	0	1	0	0	0	14707	680	24	4	655	4	SLC8A2	19	47935695	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08	29156801	47935695	11193288	88	34626										
CPT1C	126129	broad.mit.edu	37	chr19	50216744	50216744	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ggcctccctgttccaggcggGacagcattttaagcgccggt	13	13	0	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:50216744G>A	uc002ppj.2	+	19	2499	c.2294G>A	c.(2293-2295)GGA>GAA	p.G765E	CPT1C_uc002ppk.2_Missense_Mutation_p.G754E|CPT1C_uc010eng.2_Missense_Mutation_p.G765E|CPT1C_uc010enh.2_Missense_Mutation_p.G765E|CPT1C_uc010eni.1_Missense_Mutation_p.G333E	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	765	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTCCAGGCGGGACAGCATTTT	0.542													0	0	0	0.125774	0	23	101										A	50216744	G	A	50216744	3	1	115	1	0	0	0	0	1	0	0	0	3833	1174	41	1	2364	1	CPT1C	19	50216744	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	2281049	50216744	8912239	89	34627										
ZNF347	84671	broad.mit.edu	37	chr19	53644380	53644380	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cactcattacatttgtaaggTttttctccagtatggatgac	7	8	2	1			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:53644380T>C	uc002qbb.1	-	5	1770	c.1701A>G	c.(1699-1701)AAA>AAG	p.K567K	ZNF347_uc010eql.1_Silent_p.K568K|ZNF347_uc002qbc.1_Silent_p.K568K	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	567					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		ATTTGTAAGGTTTTTCTCCAG	0.413													0	0	0	0.02938	0	6	250										C	53644380	T	C	53644380	2	2	115	1	0	0	0	0	0	0	0	1	17858	1722	60	5		5	ZNF347	19	53644380	Silent	SNP	T	TCGA-GV-A3JW-01A-11D-A20D-08	3427636	53644380	5484603	90	34628										
ZNF329	79673	broad.mit.edu	37	chr19	58639722	58639722	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	tgatgcacaatgaggtgagaGtttctgttgaaggatttccc	12	6	1	4			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr19:58639722G>A	uc002qrn.2	-	4	1386	c.1149C>T	c.(1147-1149)AAC>AAT	p.N383N	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	383	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TGAGGTGAGAGTTTCTGTTGA	0.498													0	0	0	0.09836	0	35	102										A	58639722	G	A	58639722	2	1	115	1	0	0	0	0	0	0	0	1	17844	1020	36	2		2	ZNF329	19	58639722	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	4995342	58639722	489261	91	34629										
CHD6	84181	broad.mit.edu	37	chr20	40049547	40049547	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	gcttcctttcttggtttcatCttggaagccttggttctttt	8	9	4	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr20:40049547C>G	uc002xka.1	-	31	5906	c.5728G>C	c.(5728-5730)GAT>CAT	p.D1910H		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1910					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TTGGTTTCATCTTGGAAGCCT	0.517													0	0	0	0.125774	0	23	42										G	40049547	C	G	40049547	3	3	115	1	0	0	0	0	1	0	0	0	3329	913	32	1	2447	1	CHD6	20	40049547	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		40049547	22975973	92	34630										
PREX1	57580	broad.mit.edu	37	chr20	47266680	47266680	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	agaagtccaggccacacagcGggtggggctccaggggggct	18	11	0	1	rs41283554		TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr20:47266680G>A	uc002xtw.1	-	24	2905	c.2882C>T	c.(2881-2883)CCG>CTG	p.P961L	PREX1_uc002xtv.1_Missense_Mutation_p.P258L	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	961					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCCACACAGCGGGTGGGGCTC	0.592													0	0	0	0.124865	0	33	132										A	47266680	G	A	47266680	3	1	115	1	0	0	0	0	1	0	0	0	12476	1116	39	2	2165	2	PREX1	20	47266680	Missense_Mutation	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	7217133	47266680	15758840	93	34631										
IFNAR2	3455	broad.mit.edu	37	chr21	34621017	34621017	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	ttttgttttttgcacagtgtCttttgaaccaccagagtttg	8	7	1	2			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chr21:34621017C>G	uc002yrd.2	+	6	726	c.398C>G	c.(397-399)TCT>TGT	p.S133C	IFNAR2_uc002yrb.2_Missense_Mutation_p.S133C|IFNAR2_uc002yrc.2_Missense_Mutation_p.S133C|IFNAR2_uc002yre.2_Missense_Mutation_p.S133C|IFNAR2_uc002yrf.2_Missense_Mutation_p.S133C|IFNAR2_uc002yrg.2_Missense_Mutation_p.S2C|IL10RB_uc002yrh.1_5'UTR|IL10RB_uc002yri.1_5'UTR	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	133	Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	tGCACAGTGTCTTTTGAACCA	0.194													0	0	0	0.043863	0	17	80										G	34621017	C	G	34621017	3	3	115	1	0	0	0	0	1	0	0	0	7545	913	32	1	416	1	IFNAR2	21	34621017	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		34621017	13508878	94	34632										
WNK3	65267	broad.mit.edu	37	chrX	54321158	54321158	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	atagacttgcactgagaatcCctgcgttcttccaaacagcc	7	13	1	2	rs149832313	byFrequency	TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chrX:54321158C>G	uc004dtd.1	-	8	1960	c.1521G>C	c.(1519-1521)AGG>AGC	p.R507S	WNK3_uc004dtc.1_Missense_Mutation_p.R507S	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	507					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ACTGAGAATCCCTGCGTTCTT	0.478													0	0	0	0.134883	0	27	2										G	54321158	C	G	54321158	3	3	115	1	0	0	0	0	1	0	0	0	17376	622	22	4	3949	4	WNK3	23	54321158	Missense_Mutation	SNP	C	TCGA-GV-A3JW-01A-11D-A20D-08		54321158	100949402	95	34633										
MAGEC1	9947	broad.mit.edu	37	chrX	140994960	140994960	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.322916666666667	31	3.52645459940474e-09	3.15898453398453	5.0024975024975	2.34783882783883	1	1	21	cctcagggggaggactccctGtctcctcactactttcctca	8	16	4	0			TCGA-GV-A3JW-01A-11D-A20D-08	TCGA-GV-A3JW-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4534413b-d0d0-4b34-a3d4-f821705485ae	ce1d3ff8-4d0d-4764-8243-da7b6102d4ea	g.chrX:140994960G>A	uc004fbt.2	+	4	2056	c.1770G>A	c.(1768-1770)CTG>CTA	p.L590L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	590							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTGTCTCCTCACT	0.567										HNSCC(15;0.026)			0	0	0	0.02938	0	6	249										A	140994960	G	A	140994960	2	1	115	1	0	0	0	0	0	0	0	1	9180	1364	48	2		2	MAGEC1	23	140994960	Silent	SNP	G	TCGA-GV-A3JW-01A-11D-A20D-08	86673802	140994960	14275600	96	34634										
SAMD11	148398	broad.mit.edu	37	chr1	879384	879384	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggccccggagcgagaactcGgcacaggagagcagcccttg	16	13	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:879384G>A	uc001abw.1	+	14	1977	c.1897G>A	c.(1897-1899)GGC>AGC	p.G633S	SAMD11_uc001abx.1_Missense_Mutation_p.G496S	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	633						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GCGAGAACTCGGCACAGGAGA	0.682													0	0	0	0.01441	0	53	45										A	879384	G	A	879384	3	1	116	1	0	0	0	0	1	0	0	0	13816	1116	39	2	1947	2	SAMD11	1	879384	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		879384	248371237	1	34635										
TPRG1L	127262	broad.mit.edu	37	chr1	3544178	3544178	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gccactttcacagaacacccGatggctggcgcagatgagaa	11	12	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:3544178G>A	uc001akm.2	+	4	666	c.585G>A	c.(583-585)CCG>CCA	p.P195P	TPRG1L_uc009vlj.2_Silent_p.P136P	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	195						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		CAGAACACCCGATGGCTGGCG	0.532													0	0	0	0.007413	0	17	161										A	3544178	G	A	3544178	2	1	116	1	0	0	0	0	0	0	0	1	16416	1045	37	1		1	TPRG1L	1	3544178	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2664794	3544178	245706443	2	34636										
CHD5	26038	broad.mit.edu	37	chr1	6196893	6196893	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgatgagctcataggaggtGagcagcacgtggaatttgat	15	5	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:6196893G>C	uc001amb.1	-	16	2569	c.2469C>G	c.(2467-2469)CTC>CTG	p.L823L	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	823	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CATAGGAGGTGAGCAGCACGT	0.567													0	0	0	0.004289	0	28	41										C	6196893	G	C	6196893	2	2	116	1	0	0	0	0	0	0	0	1	3328	1277	45	1		1	CHD5	1	6196893	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2652715	6196893	243053728	3	34637										
PRDM2	7799	broad.mit.edu	37	chr1	14075874	14075874	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agccaatcgcgccgggcgagGagctcctggtctggtacaat	14	12	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:14075874G>A	uc001avi.2	+	6	1259	c.403G>A	c.(403-405)GAG>AAG	p.E135K	PRDM2_uc001avg.2_Missense_Mutation_p.E135K|PRDM2_uc001avh.2_Missense_Mutation_p.E135K|PRDM2_uc001avj.2_RNA|PRDM2_uc009vod.1_5'UTR|PRDM2_uc001avk.2_5'UTR|PRDM2_uc009voe.2_RNA|PRDM2_uc009vof.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	135	SET.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GCCGGGCGAGGAGCTCCTGGT	0.537													0	0	0	0.000602	0	5	37										A	14075874	G	A	14075874	3	1	116	1	0	0	0	0	1	0	0	0	12458	1175	41	1	421	1	PRDM2	1	14075874	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7878981	14075874	235174747	4	34638										
UBR4	23352	broad.mit.edu	37	chr1	19528304	19528304	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tctcatggtgcaggatttctGattcactgtaaaaataataa	7	6	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:19528304G>A	uc001bbi.2	-	2	186	c.182C>T	c.(181-183)TCA>TTA	p.S61L		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	61					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGGATTTCTGATTCACTGTA	0.219													0	0	0	0.001984	0	6	48										A	19528304	G	A	19528304	3	1	116	1	0	0	0	0	1	0	0	0	16901	1294	45	1	15789	1	UBR4	1	19528304	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5452430	19528304	229722317	5	34639										
PQLC2	54896	broad.mit.edu	37	chr1	19653762	19653762	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggatctcctactctctgttCgcgctggtgatgctggggaa	14	10	2	1	rs139194294	byFrequency	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:19653762C>T	uc001bby.2	+	8	1012	c.660C>T	c.(658-660)TTC>TTT	p.F220F	PQLC2_uc001bbz.2_Silent_p.F155F|PQLC2_uc001bca.2_Silent_p.F220F|PQLC2_uc001bcb.2_Silent_p.F109F|PQLC2_uc001bcc.2_Silent_p.F109F	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	220	PQ-loop 2.|Helical; (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ACTCTCTGTTCGCGCTGGTGA	0.552													0	0	0	0.01441	0	51	69										T	19653762	C	T	19653762	2	4	116	1	0	0	0	0	0	0	0	1	12419	883	31	1		1	PQLC2	1	19653762	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	125458	19653762	229596859	6	34640										
HNRNPR	10236	broad.mit.edu	37	chr1	23648144	23648144	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgtttaccagggcgaatttCatagctgtcacactgcaata	9	9	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:23648144C>T	uc001bgr.3	-	7	847	c.688G>A	c.(688-690)GAA>AAA	p.E230K	HNRNPR_uc001bgp.3_Missense_Mutation_p.E230K|HNRNPR_uc009vqk.2_Missense_Mutation_p.E129K|HNRNPR_uc001bgs.3_Missense_Mutation_p.E129K|HNRNPR_uc010odw.1_Missense_Mutation_p.E192K|HNRNPR_uc010odx.1_Missense_Mutation_p.E70K|HNRNPR_uc009vql.2_Missense_Mutation_p.E91K	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	230	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GGGCGAATTTCATAGCTGTCA	0.383													0	0	0	0.01441	0	78	92										T	23648144	C	T	23648144	3	4	116	1	0	0	0	0	1	0	0	0	7272	835	29	1	1242	1	HNRNPR	1	23648144	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3994382	23648144	225602477	7	34641										
ASAP3	55616	broad.mit.edu	37	chr1	23767922	23767922	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtccctcggagggagtcccgGagctgggtcagcttctgtag	16	11	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:23767922G>A	uc001bha.2	-	9	916	c.792C>T	c.(790-792)CTC>CTT	p.L264L	ASAP3_uc010odz.1_Silent_p.L133L|ASAP3_uc010oea.1_Silent_p.L255L|ASAP3_uc001bhb.2_5'Flank	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	264	Potential.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GGGAGTCCCGGAGCTGGGTCA	0.597													0	0	0	0.003163	0	11	22										A	23767922	G	A	23767922	2	1	116	1	0	0	0	0	0	0	0	1	1012	1161	41	1		1	ASAP3	1	23767922	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	119778	23767922	225482699	8	34642										
CSMD2	114784	broad.mit.edu	37	chr1	34042907	34042907	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcttctcaccttgacagagaGggatggcttcgctccacagg	12	12	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:34042907G>A	uc001bxn.1	-	50	7600	c.7571C>T	c.(7570-7572)CCT>CTT	p.P2524L	CSMD2_uc001bxm.1_Missense_Mutation_p.P2522L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2524	Sushi 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTGACAGAGAGGGATGGCTTC	0.577													0	0	0	0.01441	0	47	61										A	34042907	G	A	34042907	3	1	116	1	0	0	0	0	1	0	0	0	3945	1000	35	2	2972	2	CSMD2	1	34042907	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	10274985	34042907	215207714	9	34643										
EIF2C3	192669	broad.mit.edu	37	chr1	36520571	36520571	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccagtcgtccttcacactatCatgttttatgggatgataac	7	10	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:36520571C>T	uc001bzp.2	+	18	2555	c.2299C>T	c.(2299-2301)CAT>TAT	p.H767Y	EIF2C3_uc001bzq.2_Missense_Mutation_p.H533Y	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	767	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTCACACTATCATGTTTTATG	0.348													0	0	0	0.01441	0	46	84										T	36520571	C	T	36520571	3	4	116	1	0	0	0	0	1	0	0	0	5007	826	29	1	2369	1	EIF2C3	1	36520571	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2477664	36520571	212730050	10	34644										
EIF2C3	192669	broad.mit.edu	37	chr1	36520721	36520721	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tagcatttagagccagatatCatcttgtggacaaagaacat	8	7	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:36520721C>T	uc001bzp.2	+	18	2705	c.2449C>T	c.(2449-2451)CAT>TAT	p.H817Y	EIF2C3_uc001bzq.2_Missense_Mutation_p.H583Y	NM_024852	NP_079128	Q9H9G7	AGO3_HUMAN	eukaryotic translation initiation factor 2C, 3	817	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCCAGATATCATCTTGTGGA	0.423													0	0	0	0.000602	0	3	11										T	36520721	C	T	36520721	3	4	116	1	0	0	0	0	1	0	0	0	5007	826	29	1	2519	1	EIF2C3	1	36520721	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	150	36520721	212729900	11	34645										
MANEAL	149175	broad.mit.edu	37	chr1	38265848	38265848	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cgctgggcggagcacttcatCaaagagaaggagcagtggct	15	9	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:38265848C>T	uc001cby.2	+	4	1428	c.1347C>T	c.(1345-1347)ATC>ATT	p.I449I	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Silent_p.I227I	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	449	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGCACTTCATCAAAGAGAAGG	0.582													0	0	0	0.007835	0	35	59										T	38265848	C	T	38265848	2	4	116	1	0	0	0	0	0	0	0	1	9222	816	29	1		1	MANEAL	1	38265848	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1745127	38265848	210984773	12	34646										
ERMAP	114625	broad.mit.edu	37	chr1	43296669	43296669	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgctagtgagagatgcccaaGagggaagtgtcactctgcag	14	8	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:43296669G>A	uc001cic.1	+	4	586	c.316G>A	c.(316-318)GAG>AAG	p.E106K	ERMAP_uc010ojw.1_Missense_Mutation_p.E167K|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Missense_Mutation_p.E106K|ERMAP_uc001cif.1_Missense_Mutation_p.E16K	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	106	Ig-like V-type.|Extracellular (Potential).		DAQEGSVTLQI -> CPRGKCHSADP (in Sc-3 allele).			integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGATGCCCAAGAGGGAAGTGT	0.532													0	0	0	0.001984	0	5	67										A	43296669	G	A	43296669	3	1	116	1	0	0	0	0	1	0	0	0	5234	943	33	1	322	1	ERMAP	1	43296669	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5030821	43296669	205953952	13	34647										
NASP	4678	broad.mit.edu	37	chr1	46080036	46080036	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cggagaagttagtgttgaatCtggtaatgcattttccattt	10	5	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:46080036C>A	uc001coi.1	+	9	1766	c.1664C>A	c.(1663-1665)TCT>TAT	p.S555Y	NASP_uc001coh.1_Missense_Mutation_p.S557Y|NASP_uc001coj.1_Missense_Mutation_p.S216Y|NASP_uc010olr.1_Missense_Mutation_p.S491Y|NASP_uc001col.1_Missense_Mutation_p.S63Y	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	555	TPR 2.|Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					AGTGTTGAATCTGGTAATGCA	0.378													1	0	9.65021e-13	0.010818	1.02374e-12	25	42										A	46080036	C	A	46080036	3	1	116	1	0	0	0	0	1	0	0	0	10172	913	32	3	1775	3	NASP	1	46080036	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2783367	46080036	203170585	14	34648										
PRKACB	5567	broad.mit.edu	37	chr1	84668421	84668421	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtgctaatctatgaaatggCagctggctatcccccattct	8	11	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:84668421C>T	uc001djj.2	+	8	962	c.698C>T	c.(697-699)GCA>GTA	p.A233V	PRKACB_uc001djl.2_Missense_Mutation_p.A280V|PRKACB_uc010ort.1_Missense_Mutation_p.A240V|PRKACB_uc001djn.2_Missense_Mutation_p.A237V|PRKACB_uc010oru.1_Missense_Mutation_p.A221V|PRKACB_uc001djp.2_Missense_Mutation_p.A239V|PRKACB_uc001djq.2_Missense_Mutation_p.A203V|PRKACB_uc010orv.1_Missense_Mutation_p.A220V|PRKACB_uc001dji.2_Missense_Mutation_p.A233V|PRKACB_uc001djk.2_Missense_Mutation_p.A280V|PRKACB_uc009wcf.1_Missense_Mutation_p.A239V	NM_002731	NP_002722	P22694	KAPCB_HUMAN	cAMP-dependent protein kinase catalytic subunit	233	Protein kinase.			A -> V (in Ref. 3; CAI56774).	activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		TATGAAATGGCAGCTGGCTAT	0.373													0	0	0	0.007413	0	15	193										T	84668421	C	T	84668421	3	4	116	1	0	0	0	0	1	0	0	0	12498	710	25	2	919	2	PRKACB	1	84668421	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	38588385	84668421	164582200	15	34649										
CLCA2	9635	broad.mit.edu	37	chr1	86921014	86921014	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctccttacagtctgctgtatCtaacattgcccaggcgcctc	7	15	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:86921014C>T	uc001dlr.3	+	14	2798	c.2636C>T	c.(2635-2637)TCT>TTT	p.S879F		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	879	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCTGCTGTATCTAACATTGCC	0.423													0	0	0	0.007291	0	21	275										T	86921014	C	T	86921014	3	4	116	1	0	0	0	0	1	0	0	0	3458	913	32	1	2690	1	CLCA2	1	86921014	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2252593	86921014	162329607	16	34650										
PTBP2	58155	broad.mit.edu	37	chr1	97278831	97278831	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tttataattttgtttcagaaGagatcacaaaatggctcttc	6	6	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:97278831G>C	uc001drq.2	+	14	1713	c.1467_splice	c.e14-1	p.Q489_splice	PTBP2_uc001drn.2_Missense_Mutation_p.R495T|PTBP2_uc001dro.2_Missense_Mutation_p.R490T|PTBP2_uc010otz.1_Missense_Mutation_p.R506T|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.R438T|PTBP2_uc001drr.2_Splice_Site_p.Q494_splice|PTBP2_uc010oua.1_Missense_Mutation_p.R498T|PTBP2_uc001dru.2_Splice_Site|PTBP2_uc001drs.1_Missense_Mutation_p.R109T|PTBP2_uc001drt.2_Splice_Site_p.Q108_splice	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2								nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TGTTTCAGAAGAGATCACAAA	0.323													0	0	0	0.009096	0	3	53										C	97278831	G	C	97278831	5	2	116	1	0	0	0	0	0	0	1	0	12726	956	33	1	1520	1	PTBP2	1	97278831	Splice_Site	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	10357817	97278831	151971790	17	34651										
STXBP3	6814	broad.mit.edu	37	chr1	109339242	109339242	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	catatttttacctatttaagGaactacggaagaaaatttgg	7	5	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:109339242G>T	uc001dvy.2	+	15	1325	c.1250G>T	c.(1249-1251)GGA>GTA	p.G417V	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	417					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		CCTATTTAAGGAACTACGGAA	0.338													1	0	1.68575e-08	0.007291	1.75581e-08	26	27										T	109339242	G	T	109339242	3	4	116	1	0	0	0	0	1	0	0	0	15353	1188	41	3	1308	3	STXBP3	1	109339242	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	12060411	109339242	139911379	18	34652										
AMIGO1	57463	broad.mit.edu	37	chr1	110050083	110050083	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atgggcgtatcagagaagacCgagctgactgattctggatc	13	8	2	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:110050083C>T	uc001dxx.3	-	2	1834	c.1452G>A	c.(1450-1452)TCG>TCA	p.S484S		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	484	Cytoplasmic (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		CAGAGAAGACCGAGCTGACTG	0.582													0	0	0	0.008871	0	16	214										T	110050083	C	T	110050083	2	4	116	1	0	0	0	0	0	0	0	1	575	639	23	2		2	AMIGO1	1	110050083	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	710841	110050083	139200538	19	34653										
DDX20	11218	broad.mit.edu	37	chr1	112298569	112298569	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggcggcggcatttgaagcctCgggagccttagcagcagtgg	17	10	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:112298569C>T	uc001ebs.2	+	1	380	c.23C>T	c.(22-24)TCG>TTG	p.S8L	C1orf183_uc001ebp.1_5'Flank|uc001ebr.2_5'Flank|DDX20_uc010owf.1_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	8					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTGAAGCCTCGGGAGCCTTA	0.632													0	0	0	0.004007	0	13	29										T	112298569	C	T	112298569	3	4	116	1	0	0	0	0	1	0	0	0	4348	893	31	1	25	1	DDX20	1	112298569	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2248486	112298569	136952052	20	34654										
TTF2	8458	broad.mit.edu	37	chr1	117633952	117633952	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctttttaatctgaggcaggtCagctctgcaatcctatctaa	7	10	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:117633952C>G	uc001egy.2	+	16	2611	c.2591C>G	c.(2590-2592)TCA>TGA	p.S864*		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	864					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TGAGGCAGGTCAGCTCTGCAA	0.393													0	0	0	0.013114	0	42	77										G	117633952	C	G	117633952	4	3	116	1	0	0	0	0	0	1	0	0	16716	838	29	1	2653	1	TTF2	1	117633952	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5335383	117633952	131616669	21	34655										
HRNR	388697	broad.mit.edu	37	chr1	152190860	152190860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agctcgatgactgtcctgatGtagaaccgtgttgcccatgg	12	10	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:152190860G>A	uc001ezt.1	-	3	3321	c.3245C>T	c.(3244-3246)ACA>ATA	p.T1082I		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1082	12.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCCTGATGTAGAACCGTG	0.552													0	0	0	0.01441	0	197	517										A	152190860	G	A	152190860	3	1	116	1	0	0	0	0	1	0	0	0	7359	1377	48	2	5311	2	HRNR	1	152190860	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	34556908	152190860	97059761	22	34656										
LCE1D	353134	broad.mit.edu	37	chr1	152770489	152770489	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggggtggtggctgctgcctGagccaccacaggcgccacag	17	13	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:152770489G>A	uc009wnp.2	+	2	262	c.219G>A	c.(217-219)CTG>CTA	p.L73L		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	73	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGCTGCCTGAGCCACCACA	0.711													0	0	0	0.00308	0	8	22										A	152770489	G	A	152770489	2	1	116	1	0	0	0	0	0	0	0	1	8662	1277	45	1		1	LCE1D	1	152770489	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	579629	152770489	96480132	23	34657										
LCE1D	353134	broad.mit.edu	37	chr1	152770614	152770614	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcactctggaggctgctgctGaagtggaccttgacttcctc	12	12	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:152770614G>A	uc009wnp.2	+	2	387	c.344G>A	c.(343-345)TGA>TAA	p.*115*		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	115					cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCTGCTGCTGAAGTGGACCT	0.602													0	0	0	0.01441	0	39	2										A	152770614	G	A	152770614	2	1	116	1	0	0	0	0	0	0	0	1	8662	1285	45	1		1	LCE1D	1	152770614	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	125	152770614	96480007	24	34658										
INTS3	65123	broad.mit.edu	37	chr1	153745426	153745426	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgatctcttctccctggcgGaggaatatgaggactcttcc	11	11	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:153745426G>A	uc009wom.2	+	30	3141	c.2920G>A	c.(2920-2922)GAG>AAG	p.E974K	INTS3_uc001fct.2_Missense_Mutation_p.E974K|INTS3_uc001fcu.2_Missense_Mutation_p.E666K|INTS3_uc001fcv.2_Missense_Mutation_p.E768K|INTS3_uc010peb.1_Missense_Mutation_p.E834K|INTS3_uc001fcw.2_Missense_Mutation_p.E487K|INTS3_uc010pec.1_Missense_Mutation_p.E487K|INTS3_uc001fcy.2_Missense_Mutation_p.E337K|INTS3_uc001fcx.2_Missense_Mutation_p.E271K	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	975					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTCCCTGGCGGAGGAATATGA	0.572													0	0	0	0.006122	0	17	138										A	153745426	G	A	153745426	3	1	116	1	0	0	0	0	1	0	0	0	7779	1175	41	1	3034	1	INTS3	1	153745426	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	974812	153745426	95505195	25	34659										
ADAR	103	broad.mit.edu	37	chr1	154557296	154557296	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agcatactatactgggcagaGataaaagttcttttcctcct	7	9	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:154557296G>C	uc001ffh.2	-	15	3867	c.3667C>G	c.(3667-3669)CTC>GTC	p.L1223V	ADAR_uc001ffj.2_Missense_Mutation_p.L1178V|ADAR_uc001ffi.2_Missense_Mutation_p.L1197V|ADAR_uc001ffk.2_Missense_Mutation_p.L928V	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	1223					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		ACTGGGCAGAGATAAAAGTTC	0.483													0	0	0	0.01441	0	71	190										C	154557296	G	C	154557296	3	2	116	1	0	0	0	0	1	0	0	0	281	942	33	1	17	1	ADAR	1	154557296	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	811870	154557296	94693325	26	34660										
ADAR	103	broad.mit.edu	37	chr1	154571024	154571024	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcttccagcttcagctggggGaaactctcggccattgatga	12	11	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:154571024G>A	uc001ffh.2	-	3	1839	c.1639C>T	c.(1639-1641)CCC>TCC	p.P547S	ADAR_uc001ffj.2_Missense_Mutation_p.P547S|ADAR_uc001ffi.2_Missense_Mutation_p.P547S|ADAR_uc001ffk.2_Missense_Mutation_p.P252S	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	547	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TCAGCTGGGGGAAACTCTCGG	0.473													0	0	0	0.00245	0	12	167										A	154571024	G	A	154571024	3	1	116	1	0	0	0	0	1	0	0	0	281	1174	41	1	2093	1	ADAR	1	154571024	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	13728	154571024	94679597	27	34661										
KIRREL	55243	broad.mit.edu	37	chr1	158061194	158061194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggaggtggggaccctggaacGctatacagtggagaggacca	17	8	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:158061194G>A	uc001frn.3	+	11	1723	c.1319G>A	c.(1318-1320)CGC>CAC	p.R440H	KIRREL_uc010pib.1_Missense_Mutation_p.R340H|KIRREL_uc009wsq.2_Missense_Mutation_p.R276H|KIRREL_uc001fro.3_Missense_Mutation_p.R254H	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	440	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					ACCCTGGAACGCTATACAGTG	0.567													0	0	0	0.006999	0	41	120										A	158061194	G	A	158061194	3	1	116	1	0	0	0	0	1	0	0	0	8324	1087	38	2	1361	2	KIRREL	1	158061194	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3490170	158061194	91189427	28	34662										
OR6Y1	391112	broad.mit.edu	37	chr1	158517192	158517192	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccttttggcggccctgagcaGaagggatcctgaggatggtg	16	9	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:158517192G>A	uc010pil.1	-	1	704	c.704C>T	c.(703-705)TCT>TTT	p.S235F		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GCCCTGAGCAGAAGGGATCCT	0.522													0	0	0	0.01441	0	55	95										A	158517192	G	A	158517192	3	1	116	1	0	0	0	0	1	0	0	0	11213	942	33	1	275	1	OR6Y1	1	158517192	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	455998	158517192	90733429	29	34663										
OR10J1	26476	broad.mit.edu	37	chr1	159409658	159409658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttccatgagcagcagatcaCcctttttggcgtgttccttg	9	12	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:159409658C>T	uc010piv.1	+	1	110	c.110C>T	c.(109-111)ACC>ATC	p.T37I	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	37	Helical; Name=1; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					CAGCAGATCACCCTTTTTGGC	0.418													0	0	0	0.01441	0	177	124										T	159409658	C	T	159409658	3	4	116	1	0	0	0	0	1	0	0	0	10910	507	18	2	112	2	OR10J1	1	159409658	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	892466	159409658	89840963	30	34664										
IGSF9	57549	broad.mit.edu	37	chr1	159897219	159897219	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtagcatctcggcggcggcgGaaggccaggaattcctcccg	15	13	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:159897219G>A	uc001fur.2	-	21	3654	c.3456C>T	c.(3454-3456)TTC>TTT	p.F1152F	IGSF9_uc001fuq.2_Silent_p.F1136F|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.F298F	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1152	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GGCGGCGGCGGAAGGCCAGGA	0.632													0	0	0	0.01441	0	46	106										A	159897219	G	A	159897219	2	1	116	1	0	0	0	0	0	0	0	1	7605	1165	41	1		1	IGSF9	1	159897219	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	487561	159897219	89353402	31	34665										
BLZF1	8548	broad.mit.edu	37	chr1	169345923	169345923	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagaaagcagttccatcagaGagcccaggagttcttcagct	10	10	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:169345923G>C	uc001gfx.1	+	3	611	c.174G>C	c.(172-174)GAG>GAC	p.E58D	BLZF1_uc001gfw.2_Missense_Mutation_p.E58D|BLZF1_uc001gfy.2_Missense_Mutation_p.E58D|BLZF1_uc009wvp.1_Missense_Mutation_p.E35D	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	58					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					TTCCATCAGAGAGCCCAGGAG	0.413													0	0	0	0.014323	0	20	83										C	169345923	G	C	169345923	3	2	116	1	0	0	0	0	1	0	0	0	1453	933	33	1	180	1	BLZF1	1	169345923	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	9448704	169345923	79904698	32	34666										
BLZF1	8548	broad.mit.edu	37	chr1	169346158	169346158	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tggaaaagctcaagaattctGaaagaaggttactacaggac	10	6	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:169346158G>C	uc001gfx.1	+	3	846	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	BLZF1_uc001gfw.2_Missense_Mutation_p.E137Q|BLZF1_uc001gfy.2_Missense_Mutation_p.E137Q|BLZF1_uc009wvp.1_Missense_Mutation_p.E114Q	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	137	Potential.				cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					CAAGAATTCTGAAAGAAGGTT	0.383													0	0	0	0.010818	0	25	49										C	169346158	G	C	169346158	3	2	116	1	0	0	0	0	1	0	0	0	1453	1291	45	1	415	1	BLZF1	1	169346158	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	235	169346158	79904463	33	34667										
SCYL3	57147	broad.mit.edu	37	chr1	169825055	169825055	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaggggttctccaagattggCgagatctgactgtgatggct	14	7	2	4	rs75739679	byFrequency	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:169825055C>T	uc001ggs.2	-	12	1554	c.1356G>A	c.(1354-1356)TCG>TCA	p.S452S	SCYL3_uc010plw.1_Intron|SCYL3_uc001ggt.2_Intron|SCYL3_uc001ggu.2_Intron	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	452					cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCAAGATTGGCGAGATCTGAC	0.428													0	0	0	0.000602	0	4	133										T	169825055	C	T	169825055	2	4	116	1	0	0	0	0	0	0	0	1	13949	755	27	2		2	SCYL3	1	169825055	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	478897	169825055	79425566	34	34668										
TPR	7175	broad.mit.edu	37	chr1	186326652	186326652	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgtaagatactagatgctgtGatattacctcagatgaacta	8	6	1	5			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:186326652G>A	uc001grv.2	-	14	1898	c.1601C>T	c.(1600-1602)TCA>TTA	p.S534L	TPR_uc010pop.1_Missense_Mutation_p.S610L	NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	534	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TAGATGCTGTGATATTACCTC	0.403			T	NTRK1	papillary thyroid								0	0	0	0.013114	0	44	83										A	186326652	G	A	186326652	3	1	116	1	0	0	0	0	1	0	0	0	16413	1294	45	1	5642	1	TPR	1	186326652	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	16501597	186326652	62923969	35	34669										
CFH	3075	broad.mit.edu	37	chr1	196643008	196643008	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaggccctgtggacatcctgGagatactccttttggtactt	10	10	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:196643008G>C	uc001gtj.3	+	3	506	c.266G>C	c.(265-267)GGA>GCA	p.G89A	CFH_uc001gti.3_Missense_Mutation_p.G89A|CFH_uc009wyw.2_Missense_Mutation_p.G89A|CFH_uc009wyx.2_Missense_Mutation_p.G89A	NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	89	Sushi 2.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GGACATCCTGGAGATACTCCT	0.363													0	0	0	0.004007	0	13	199										C	196643008	G	C	196643008	3	2	116	1	0	0	0	0	1	0	0	0	3283	1174	41	1	276	1	CFH	1	196643008	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	10316356	196643008	52607613	36	34670										
LAD1	3898	broad.mit.edu	37	chr1	201351425	201351425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttctgtccccactgagtcctCtcggttgcagatgatgcttt	9	12	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:201351425C>G	uc001gwm.2	-	9	1738	c.1503G>C	c.(1501-1503)GAG>GAC	p.E501D		NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	501						basement membrane	structural molecule activity				0						ACTGAGTCCTCTCGGTTGCAG	0.607													0	0	0	0.01441	0	107	59										G	201351425	C	G	201351425	3	3	116	1	0	0	0	0	1	0	0	0	8599	912	32	1	58	1	LAD1	1	201351425	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4708417	201351425	47899196	37	34671										
ATP2B4	493	broad.mit.edu	37	chr1	203676348	203676348	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atctcactggcctactctgtGaaggtgagactagaacaatc	9	10	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:203676348G>A	uc001gzw.2	+	9	2195	c.1311G>A	c.(1309-1311)GTG>GTA	p.V437V	ATP2B4_uc001gzv.2_Silent_p.V437V|ATP2B4_uc009xaq.2_Silent_p.V437V	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	437	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTACTCTGTGAAGGTGAGAC	0.468													0	0	0	0.001984	0	7	115										A	203676348	G	A	203676348	2	1	116	1	0	0	0	0	0	0	0	1	1142	1277	45	1		1	ATP2B4	1	203676348	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2324923	203676348	45574273	38	34672										
PIGR	5284	broad.mit.edu	37	chr1	207112588	207112588	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	accacaaatgtgccgttctcCgggaagttggtgaggttagc	13	9	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:207112588C>T	uc001hez.2	-	3	448	c.264G>A	c.(262-264)CCG>CCA	p.P88P	PIGR_uc009xbz.2_Silent_p.P88P	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	88	Ig-like V-type 1.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGCCGTTCTCCGGGAAGTTGG	0.592													0	0	0	0.009096	0	4	91										T	207112588	C	T	207112588	2	4	116	1	0	0	0	0	0	0	0	1	11897	639	23	2		2	PIGR	1	207112588	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3436240	207112588	42138033	39	34673										
INTS7	25896	broad.mit.edu	37	chr1	212115191	212115193	+	In_Frame_Del	DEL	TGC	TGC	-													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	accgtgtgtaggcattgcgtTgctgctgctgctgtaatggc							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:212115191_212115193delTGC	uc001hiw.1	-	20	2967_2969	c.2862_2864delGCA	c.(2860-2865)CAGCAA>CAA	p.954_955QQ>Q	INTS7_uc009xdb.1_In_Frame_Del_p.934_935QQ>Q|INTS7_uc001hix.1_In_Frame_Del_p.830_831QQ>Q|INTS7_uc001hiy.1_In_Frame_Del_p.940_941QQ>Q|INTS7_uc010pta.1_In_Frame_Del_p.905_906QQ>Q	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	954_955	Gln-rich.				snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GGCATTGCGTTGCTGCTGCTGCT	0.443																		9	353	---	---								-	212115193	TGC	-	212115191	7	5	116	1	0	1	0	1	0	0	0	0	7783	1812	63	0	28	0	INTS7	1	212115191	In_Frame_Del	DEL	TGC	TCGA-GV-A3JX-01A-11D-A20D-08	5002603	212115191	37135430	40	34674										
NSL1	25936	broad.mit.edu	37	chr1	212911828	212911828	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tctttagtttgctttcttttCagtaccatgtcagaggtttt	7	7	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:212911828C>T	uc001hjn.2	-	6	802	c.768G>A	c.(766-768)CTG>CTA	p.L256L	NSL1_uc001hjm.2_3'UTR|NSL1_uc010pti.1_Silent_p.L215L	NM_015471	NP_056286	Q96IY1	NSL1_HUMAN	NSL1, MIND kinetochore complex component isoform	256					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		GCTTTCTTTTCAGTACCATGT	0.398													0	0	0	0.005443	0	20	176										T	212911828	C	T	212911828	2	4	116	1	0	0	0	0	0	0	0	1	10673	813	29	1		1	NSL1	1	212911828	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	796637	212911828	36338793	41	34675										
EPRS	2058	broad.mit.edu	37	chr1	220174523	220174523	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tggtcttttcctttgaccctGatgttggcatttcctttgtg	9	9	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr1:220174523G>T	uc001hly.1	-	17	2408	c.2138C>A	c.(2137-2139)TCA>TAA	p.S713*	EPRS_uc010puf.1_Nonsense_Mutation_p.S464*|EPRS_uc001hlz.1_Nonsense_Mutation_p.S720*|EPRS_uc009xdt.1_Nonsense_Mutation_p.S301*	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	713	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	CTTTGACCCTGATGTTGGCAT	0.373													1	0	2.81731e-10	0.010818	2.95744e-10	29	65										T	220174523	G	T	220174523	4	4	116	1	0	0	0	0	0	1	0	0	5191	1294	45	3	2464	3	EPRS	1	220174523	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7262695	220174523	29076098	42	34676										
CCDC88A	55704	broad.mit.edu	37	chr2	55563882	55563882	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgagctttctccttcattaGatccttgcttaaattctgac	5	11	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:55563882G>C	uc002ryv.2	-	14	2433	c.1591C>G	c.(1591-1593)CTA>GTA	p.L531V	CCDC88A_uc010yoz.1_Missense_Mutation_p.L531V|CCDC88A_uc010ypa.1_Missense_Mutation_p.L531V|CCDC88A_uc010ypb.1_Missense_Mutation_p.L433V|CCDC88A_uc002ryu.2_5'Flank|CCDC88A_uc002ryw.2_5'Flank	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	531	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TCCTTCATTAGATCCTTGCTT	0.299													0	0	0	0.010729	0	11	90										C	55563882	G	C	55563882	3	2	116	1	0	0	0	0	1	0	0	0	2863	933	33	1	4100	1	CCDC88A	2	55563882	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		55563882	187635491	43	34677										
KCNIP3	30818	broad.mit.edu	37	chr2	96048223	96048223	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcggagcacgtggagaggttCttcgaggtgagcgagcgcca	18	9	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:96048223C>T	uc002sup.2	+	7	769	c.654C>T	c.(652-654)TTC>TTT	p.F218F	KCNIP3_uc002suq.2_Silent_p.F192F	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	218	EF-hand 4.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		TGGAGAGGTTCTTCGAGGTGA	0.657													0	0	0	0.012213	0	25	24										T	96048223	C	T	96048223	2	4	116	1	0	0	0	0	0	0	0	1	8041	912	32	1		1	KCNIP3	2	96048223	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	40484341	96048223	147151150	44	34678										
PSD4	23550	broad.mit.edu	37	chr2	113940993	113940993	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggcattgtacccctccattCcctgtgcccatctataaacc	6	16	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:113940993C>T	uc002tjc.2	+	2	1143	c.960C>T	c.(958-960)TTC>TTT	p.F320F	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Silent_p.F319F|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	320					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CCCCTCCATTCCCTGTGCCCA	0.607													0	0	0	0.000602	0	4	84										T	113940993	C	T	113940993	2	4	116	1	0	0	0	0	0	0	0	1	12649	854	30	1		1	PSD4	2	113940993	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	17892770	113940993	129258380	45	34679										
PLA2R1	22925	broad.mit.edu	37	chr2	160833209	160833209	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcttaccgtactggtaccaGaacggaatcttgggtttcac	9	10	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:160833209G>A	uc002ube.1	-	16	2631	c.2424C>T	c.(2422-2424)TTC>TTT	p.F808F	PLA2R1_uc010zcp.1_Silent_p.F808F|PLA2R1_uc002ubf.2_Silent_p.F808F	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	808	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						ACTGGTACCAGAACGGAATCT	0.353													0	0	0	0.006214	0	6	92										A	160833209	G	A	160833209	2	1	116	1	0	0	0	0	0	0	0	1	12010	933	33	1		1	PLA2R1	2	160833209	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	46892216	160833209	82366164	46	34680										
PLA2R1	22925	broad.mit.edu	37	chr2	160840459	160840459	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caattaaattttgaatgtaaGagctcattcacaaaattctc	4	7	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:160840459G>C	uc002ube.1	-	13	2370	c.2163C>G	c.(2161-2163)CTC>CTG	p.L721L	PLA2R1_uc010zcp.1_Silent_p.L721L|PLA2R1_uc002ubf.2_Silent_p.L721L	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	721	Extracellular (Potential).|C-type lectin 4.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTGAATGTAAGAGCTCATTCA	0.353													0	0	0	0.009096	0	4	63										C	160840459	G	C	160840459	2	2	116	1	0	0	0	0	0	0	0	1	12010	929	33	1		1	PLA2R1	2	160840459	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7250	160840459	82358914	47	34681										
SCN9A	6335	broad.mit.edu	37	chr2	167159806	167159806	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcaaagcccctacaattgtcTtcaggcctgaaaatgggaga	9	10	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:167159806T>G	uc010fpl.2	-	7	1036	c.695A>C	c.(694-696)AAG>ACG	p.K232T	SCN9A_uc002udr.1_Missense_Mutation_p.K103T|SCN9A_uc002uds.1_Missense_Mutation_p.K103T|SCN9A_uc002udt.1_Missense_Mutation_p.K103T	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	232	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TACAATTGTCTTCAGGCCTGA	0.393													0	0	0	0.004289	0	32	34										G	167159806	T	G	167159806	3	3	116	1	0	0	0	0	1	0	0	0	13925	1609	56	5	5322	5	SCN9A	2	167159806	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	6319347	167159806	76039567	48	34682										
NOSTRIN	115677	broad.mit.edu	37	chr2	169681198	169681198	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagaaactggcaagcaagctGagcaaagcattacagaacac	9	10	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:169681198G>A	uc002ueg.2	+	3	172	c.168G>A	c.(166-168)CTG>CTA	p.L56L	NOSTRIN_uc002uef.2_Silent_p.L56L|NOSTRIN_uc002uei.2_5'UTR|NOSTRIN_uc010fpu.2_Intron|NOSTRIN_uc002ueh.2_5'UTR|NOSTRIN_uc002uej.2_5'UTR	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	56	FCH.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						CAAGCAAGCTGAGCAAAGCAT	0.323													0	0	0	0.006214	0	8	88										A	169681198	G	A	169681198	2	1	116	1	0	0	0	0	0	0	0	1	10546	1277	45	1		1	NOSTRIN	2	169681198	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2521392	169681198	73518175	49	34683										
DFNB59	494513	broad.mit.edu	37	chr2	179319144	179319144	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggtaaccatattgtaaatgaCgttgggattaacgttgctgg	12	5	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179319144C>T	uc002umi.3	+	3	653	c.297C>T	c.(295-297)GAC>GAT	p.D99D	DFNB59_uc002umj.3_Silent_p.D99D	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	99					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			TTGTAAATGACGTTGGGATTA	0.338													0	0	0	0.00308	0	6	119										T	179319144	C	T	179319144	2	4	116	1	0	0	0	0	0	0	0	1	4456	535	19	2		2	DFNB59	2	179319144	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	9637946	179319144	63880229	50	34684										
TTN	7273	broad.mit.edu	37	chr2	179438342	179438342	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tacttggacttctgaggctaCatttgtccatgccaatctgc	8	11	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179438342C>G	uc010zfg.1	-	275	65037	c.64813G>C	c.(64813-64815)GTA>CTA	p.V21605L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V15300L|TTN_uc010zfi.1_Missense_Mutation_p.V15233L|TTN_uc010zfj.1_Missense_Mutation_p.V15108L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22532							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGAGGCTACATTTGTCCAT	0.413													0	0	0	0.001855	0	11	398										G	179438342	C	G	179438342	3	3	116	1	0	0	0	0	1	0	0	0	16732	478	17	4	35610	4	TTN	2	179438342	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	119198	179438342	63761031	51	34685										
TTN	7273	broad.mit.edu	37	chr2	179588019	179588019	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttccctggttctacagaatGatcacttaatctcttcaaaa	4	11	4	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179588019G>T	uc010zfg.1	-	72	18207	c.17983C>A	c.(17983-17985)CAT>AAT	p.H5995N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.H2656N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6922							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACAGAATGATCACTTAAT	0.388													1	0	9.16793e-09	0.00499	9.5738e-09	14	36										T	179588019	G	T	179588019	3	4	116	1	0	0	0	0	1	0	0	0	16732	1290	45	3	82966	3	TTN	2	179588019	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	149677	179588019	63611354	52	34686										
TTN	7273	broad.mit.edu	37	chr2	179612864	179612864	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acttctgcctccattttctaGaggacaacttttctcagaaa	5	11	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:179612864G>C	uc002unb.2	-	46	14487	c.14263C>G	c.(14263-14265)CTA>GTA	p.L4755V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATTTTCTAGAGGACAACTT	0.388													0	0	0	0.00333	0	17	28										C	179612864	G	C	179612864	3	2	116	1	0	0	0	0	1	0	0	0	16732	933	33	1	96034	1	TTN	2	179612864	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	24845	179612864	63586509	53	34687										
MFSD6	54842	broad.mit.edu	37	chr2	191362263	191362263	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agacagaagatgtcatgccaCgcattgagcccagacttcca	9	12	1	5			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:191362263C>G	uc002urz.2	+	7	2314	c.1990C>G	c.(1990-1992)CGC>GGC	p.R664G	MFSD6_uc010zge.1_Missense_Mutation_p.R126G	NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing	664					transmembrane transport	integral to membrane				ovary(2)	2						TGTCATGCCACGCATTGAGCC	0.502													0	0	0	0.003163	0	12	145										G	191362263	C	G	191362263	3	3	116	1	0	0	0	0	1	0	0	0	9535	536	19	4	2008	4	MFSD6	2	191362263	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	11749399	191362263	51837110	54	34688										
SDPR	8436	broad.mit.edu	37	chr2	192701216	192701216	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcttgaggctatccactttCttcaggctggatctttttat	7	9	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:192701216C>G	uc002utb.2	-	2	1041	c.711G>C	c.(709-711)AAG>AAC	p.K237N		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	237	Potential.					caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TATCCACTTTCTTCAGGCTGG	0.463													0	0	0	0.006122	0	18	226										G	192701216	C	G	192701216	3	3	116	1	0	0	0	0	1	0	0	0	13970	912	32	1	570	1	SDPR	2	192701216	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1338953	192701216	50498157	55	34689										
HSPD1	3329	broad.mit.edu	37	chr2	198358053	198358053	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	accactgcttattacctattCaagacgagtgtacttagagc	7	10	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:198358053C>G	uc002uui.2	-	7	1001	c.864G>C	c.(862-864)TTG>TTC	p.L288F	HSPD1_uc002uuj.2_Missense_Mutation_p.L286F|HSPD1_uc010zgx.1_Missense_Mutation_p.L279F|HSPD1_uc010fsm.2_Missense_Mutation_p.L99F|HSPD1_uc002uuk.2_Missense_Mutation_p.L288F	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	288					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			ATTACCTATTCAAGACGAGTG	0.393													0	0	0	0.00499	0	13	184										G	198358053	C	G	198358053	3	3	116	1	0	0	0	0	1	0	0	0	7428	825	29	1	881	1	HSPD1	2	198358053	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5656837	198358053	44841320	56	34690										
NOP58	51602	broad.mit.edu	37	chr2	203164980	203164980	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtgaagacttacgatccttCtggtgactccacacttccaa	7	12	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:203164980C>G	uc002uzb.2	+	13	1442	c.1292C>G	c.(1291-1293)TCT>TGT	p.S431C		NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	431					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0						TACGATCCTTCTGGTGACTCC	0.333													0	0	0	0.010729	0	11	89										G	203164980	C	G	203164980	3	3	116	1	0	0	0	0	1	0	0	0	10540	913	32	1	1342	1	NOP58	2	203164980	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4806927	203164980	40034393	57	34691										
PLEKHM3	389072	broad.mit.edu	37	chr2	208795681	208795681	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atcctctgccaccgctgcccGgcagctgaacaaataggctc	9	16	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:208795681G>A	uc002vcl.2	-	5	2345	c.1855C>T	c.(1855-1857)CGG>TGG	p.R619W	PLEKHM3_uc002vcm.2_Missense_Mutation_p.R619W	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	619					intracellular signal transduction		metal ion binding			ovary(1)	1						ACCGCTGCCCGGCAGCTGAAC	0.622													0	0	0	0.001168	0	5	99										A	208795681	G	A	208795681	3	1	116	1	0	0	0	0	1	0	0	0	12082	1115	39	2	446	2	PLEKHM3	2	208795681	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5630701	208795681	34403692	58	34692										
ZNF142	7701	broad.mit.edu	37	chr2	219508869	219508869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aatgggggcaagggtgctgtCtcagcaggtggagttgtctt	17	6	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:219508869C>T	uc002vin.2	-	8	2806	c.2370G>A	c.(2368-2370)GAG>GAA	p.E790E	ZNF142_uc002vil.2_Silent_p.E751E|ZNF142_uc010fvt.2_Silent_p.E627E|ZNF142_uc002vim.2_Silent_p.E627E	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	790					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGGTGCTGTCTCAGCAGGTG	0.532													0	0	0	0.008291	0	6	198										T	219508869	C	T	219508869	2	4	116	1	0	0	0	0	0	0	0	1	17728	912	32	1		1	ZNF142	2	219508869	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	10713188	219508869	23690504	59	34693										
CYP27A1	1593	broad.mit.edu	37	chr2	219679356	219679356	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccagccccaccgctggctgaGaaacagccagcctgctaccc	9	19	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:219679356G>C	uc002viz.3	+	8	1786	c.1352G>C	c.(1351-1353)AGA>ACA	p.R451T		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	451					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	CGCTGGCTGAGAAACAGCCAG	0.607													0	0	0	0.001984	0	6	60										C	219679356	G	C	219679356	3	2	116	1	0	0	0	0	1	0	0	0	4158	942	33	1	1382	1	CYP27A1	2	219679356	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	170487	219679356	23520017	60	34694										
ANKZF1	55139	broad.mit.edu	37	chr2	220100580	220100580	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agcagcggcgatttgccgccCtcagtgaccgagagaaggtg	15	11	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr2:220100580C>T	uc002vkg.2	+	12	2128	c.1954C>T	c.(1954-1956)CTC>TTC	p.L652F	ANKZF1_uc002vkh.2_Missense_Mutation_p.L442F|ANKZF1_uc002vki.2_Missense_Mutation_p.L652F	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	652	Potential.					intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATTTGCCGCCCTCAGTGACCG	0.622													0	0	0	0.01441	0	46	93										T	220100580	C	T	220100580	3	4	116	1	0	0	0	0	1	0	0	0	693	681	24	2	1996	2	ANKZF1	2	220100580	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	421224	220100580	23098793	61	34695										
IRAK2	3656	broad.mit.edu	37	chr3	10254974	10254974	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tggagtgaggcagacgtggtCcaggcaaccgatgacttcaa	14	9	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:10254974C>G	uc003bve.1	+	5	688	c.612C>G	c.(610-612)GTC>GTG	p.V204V		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	204					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						CAGACGTGGTCCAGGCAACCG	0.527													0	0	0	0.003163	0	14	66										G	10254974	C	G	10254974	2	3	116	1	0	0	0	0	0	0	0	1	7823	842	30	1		1	IRAK2	3	10254974	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		10254974	187767456	62	34696										
TATDN2	9797	broad.mit.edu	37	chr3	10301923	10301923	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aacccaacaaggtccagaaaAggaagagggatagacttcga	11	8	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:10301923A>G	uc003bvg.2	+	3	1098	c.517A>G	c.(517-519)AGG>GGG	p.R173G	TATDN2_uc003bvf.2_Missense_Mutation_p.R173G|TATDN2_uc011atr.1_Missense_Mutation_p.R173G|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	173						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						GGTCCAGAAAAGGAAGAGGGA	0.473													0	0	0	0.01441	0	47	41										G	10301923	A	G	10301923	3	3	116	1	0	0	0	0	1	0	0	0	15589	63	3	5	523	5	TATDN2	3	10301923	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	46949	10301923	187720507	63	34697										
NUP210	23225	broad.mit.edu	37	chr3	13381432	13381432	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acagtgccgttcccgatggcGaggccctgtaccagcccagc	12	16	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:13381432G>A	uc003bxv.1	-	25	3476	c.3393C>T	c.(3391-3393)CTC>CTT	p.L1131L		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1131	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TCCCGATGGCGAGGCCCTGTA	0.493													0	0	0	0.01441	0	79	109										A	13381432	G	A	13381432	2	1	116	1	0	0	0	0	0	0	0	1	10760	1045	37	1		1	NUP210	3	13381432	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3079509	13381432	184640998	64	34698										
RFTN1	23180	broad.mit.edu	37	chr3	16475483	16475483	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccctgctggtacagctccagGagctgggcgggcaggtcacg	16	13	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:16475483G>A	uc003cay.2	-	3	489	c.207C>T	c.(205-207)CTC>CTT	p.L69L	RFTN1_uc010hes.2_Silent_p.L33L	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	69						plasma membrane				ovary(3)|central_nervous_system(1)	4						ACAGCTCCAGGAGCTGGGCGG	0.652													0	0	0	0.00333	0	23	30										A	16475483	G	A	16475483	2	1	116	1	0	0	0	0	0	0	0	1	13258	1161	41	1		1	RFTN1	3	16475483	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3094051	16475483	181546947	65	34699										
TRANK1	9881	broad.mit.edu	37	chr3	36874032	36874032	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctcctggtggagcagcttttCaaactcctccgggtagttgg	12	11	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:36874032C>G	uc003cgj.2	-	12	5562	c.5260G>C	c.(5260-5262)GAA>CAA	p.E1754Q		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2304	Potential.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGCAGCTTTTCAAACTCCTCC	0.522													0	0	0	0.003755	0	35	33										G	36874032	C	G	36874032	3	3	116	1	0	0	0	0	1	0	0	0	16451	835	29	1	1879	1	TRANK1	3	36874032	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	20398549	36874032	161148398	66	34700										
SCN11A	11280	broad.mit.edu	37	chr3	38988357	38988357	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aacaaggcatgcttggcactGaagcggtagattgtcctctt	11	9	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:38988357G>A	uc011ays.1	-	2	508	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	103					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCTTGGCACTGAAGCGGTAGA	0.363													0	0	0	0.009535	0	26	56										A	38988357	G	A	38988357	2	1	116	1	0	0	0	0	0	0	0	1	13913	1281	45	1		1	SCN11A	3	38988357	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2114325	38988357	159034073	67	34701										
TGM4	7047	broad.mit.edu	37	chr3	44926861	44926861	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcttgaatcaggacaacgccGtttctcaccacacatgggag	9	12	3	1	rs141141838		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:44926861G>A	uc003coc.3	+	2	137	c.64G>A	c.(64-66)GTT>ATT	p.V22I	TGM4_uc003coa.2_Missense_Mutation_p.V22I|TGM4_uc003cob.2_RNA	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	22					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GGACAACGCCGTTTCTCACCA	0.517													0	0	0	0.004007	0	12	32										A	44926861	G	A	44926861	3	1	116	1	0	0	0	0	1	0	0	0	15829	1145	40	2	70	2	TGM4	3	44926861	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5938504	44926861	153095569	68	34702										
ITIH4	3700	broad.mit.edu	37	chr3	52859944	52859944	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcccggtccacatcatagcgGataatgaggttgccgtccag	12	12	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:52859944G>A	uc003dfz.2	-	6	753	c.717C>T	c.(715-717)ATC>ATT	p.I239I	ITIH4_uc011bel.1_5'UTR|ITIH4_uc003dfy.2_Silent_p.I103I|ITIH4_uc011bem.1_Silent_p.I239I|ITIH4_uc011ben.1_Silent_p.I239I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	239					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CATCATAGCGGATAATGAGGT	0.572													0	0	0	0.008291	0	8	81										A	52859944	G	A	52859944	2	1	116	1	0	0	0	0	0	0	0	1	7906	1164	41	1		1	ITIH4	3	52859944	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7933083	52859944	145162486	69	34703										
EPHA3	2042	broad.mit.edu	37	chr3	89259649	89259649	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cctgcaatgctggctatgaaGaaagaggttttatgtgccaa	11	7	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:89259649G>A	uc003dqy.2	+	3	1018	c.793G>A	c.(793-795)GAA>AAA	p.E265K	EPHA3_uc003dqx.1_Missense_Mutation_p.E265K|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	265	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGGCTATGAAGAAAGAGGTTT	0.403										TSP Lung(6;0.00050)			0	0	0	0.01441	0	112	147										A	89259649	G	A	89259649	3	1	116	1	0	0	0	0	1	0	0	0	5168	943	33	1	803	1	EPHA3	3	89259649	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	36399705	89259649	108762781	70	34704										
RPL24	6152	broad.mit.edu	37	chr3	101404687	101404687	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtccctttttgtgcttccttCtgtagaggacagtccagttt	9	10	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:101404687C>G	uc003dvh.1	-	3	210	c.167G>C	c.(166-168)AGA>ACA	p.R56T	RPL24_uc003dvi.1_Missense_Mutation_p.R56T	NM_000986	NP_000977	P83731	RL24_HUMAN	ribosomal protein L24	56					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						GTGCTTCCTTCTGTAGAGGAC	0.458													0	0	0	0.01441	0	44	49										G	101404687	C	G	101404687	3	3	116	1	0	0	0	0	1	0	0	0	13572	913	32	1	322	1	RPL24	3	101404687	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	12145038	101404687	96617743	71	34705										
CBLB	868	broad.mit.edu	37	chr3	105377987	105377987	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gacattttccaatgccgcctCaggcccatggggttttctgt	10	12	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:105377987C>T	uc003dwc.2	-	19	3098	c.2776G>A	c.(2776-2778)GAG>AAG	p.E926K	CBLB_uc003dwa.2_Missense_Mutation_p.E141K|CBLB_uc011bhi.1_Missense_Mutation_p.E904K	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	926	Interaction with SH3KBP1.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						AATGCCGCCTCAGGCCCATGG	0.493			Mis S		AML								0	0	0	0.006214	0	9	115										T	105377987	C	T	105377987	3	4	116	1	0	0	0	0	1	0	0	0	2701	835	29	1	176	1	CBLB	3	105377987	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3973300	105377987	92644443	72	34706										
KALRN	8997	broad.mit.edu	37	chr3	124048774	124048774	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtctgccatccgagatgcaaGacctagagctggcaatccac	10	13	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:124048774G>T	uc003ehg.2	+	8	1472	c.1345G>T	c.(1345-1347)GAC>TAC	p.D449Y	KALRN_uc010hrv.1_Missense_Mutation_p.D449Y|KALRN_uc003ehf.1_Missense_Mutation_p.D449Y|KALRN_uc011bjy.1_Missense_Mutation_p.D449Y	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	449					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CGAGATGCAAGACCTAGAGCT	0.572													1	0	0.00074312	0.006122	0.000756323	15	117										T	124048774	G	T	124048774	3	4	116	1	0	0	0	0	1	0	0	0	7975	942	33	3	1375	3	KALRN	3	124048774	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	18670787	124048774	73973656	73	34707										
COPG	22820	broad.mit.edu	37	chr3	128973917	128973917	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agctctgccctcgtgtcttcCttggtgtgtagttgctgctg	12	11	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:128973917C>T	uc003els.2	+	7	589	c.489C>T	c.(487-489)TCC>TCT	p.S163S	COPG_uc010htb.2_Silent_p.S69S	NM_016128	NP_057212	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	163					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(3)|breast(1)	4						TCGTGTCTTCCTTGGTGTGTA	0.483													0	0	0	0.008871	0	17	33										T	128973917	C	T	128973917	2	4	116	1	0	0	0	0	0	0	0	1	3731	668	24	2		2	COPG	3	128973917	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4925143	128973917	69048513	74	34708										
ACAD11	84129	broad.mit.edu	37	chr3	132347277	132347277	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aattatttcccagaagatatCtgctatatactccctataaa	3	9	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:132347277C>G	uc003eov.3	-	8	1357	c.977G>C	c.(976-978)AGA>ACA	p.R326T	ACAD11_uc011blr.1_5'Flank|ACAD11_uc003eoy.2_Missense_Mutation_p.R326T	NM_032169	NP_115545	Q709F0	ACD11_HUMAN	putative acyl-CoA dehydrogenase	326						peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1						CAGAAGATATCTGCTATATAC	0.348													0	0	0	0.004482	0	7	96										G	132347277	C	G	132347277	3	3	116	1	0	0	0	0	1	0	0	0	109	913	32	1	1417	1	ACAD11	3	132347277	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3373360	132347277	65675153	75	34709										
TOPBP1	11073	broad.mit.edu	37	chr3	133362970	133362970	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgctcagaagggacatgattTtcccagcattttcttttatg	8	8	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:133362970T>C	uc003eps.2	-	11	1874	c.1742A>G	c.(1741-1743)AAA>AGA	p.K581R		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	581	BRCT 4.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						GGACATGATTTTCCCAGCATT	0.403								Other_conserved_DNA_damage_response_genes					0	0	0	0.006999	0	38	48										C	133362970	T	C	133362970	3	2	116	1	0	0	0	0	1	0	0	0	16366	1841	64	5	2898	5	TOPBP1	3	133362970	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	1015693	133362970	64659460	76	34710										
WDR49	151790	broad.mit.edu	37	chr3	167248966	167248966	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cataacagcatttttgccctCagtgtcaatctcaaagttgc	6	11	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:167248966C>T	uc003fev.1	-	9	1405	c.1099G>A	c.(1099-1101)GAG>AAG	p.E367K	WDR49_uc003feu.1_Missense_Mutation_p.E192K|WDR49_uc011bpd.1_Missense_Mutation_p.E431K|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	367	WD 6.									large_intestine(1)|ovary(1)|skin(1)	3						TTTTTGCCCTCAGTGTCAATC	0.408													0	0	0	0.001168	0	6	112										T	167248966	C	T	167248966	3	4	116	1	0	0	0	0	1	0	0	0	17299	835	29	1	1022	1	WDR49	3	167248966	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	33885996	167248966	30773464	77	34711										
TNFSF10	8743	broad.mit.edu	37	chr3	172229441	172229441	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atggtttcctcagaggttctCaaaatcatctgcaaatatta	6	8	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:172229441C>G	uc003fid.2	-	3	374	c.279G>C	c.(277-279)TTG>TTC	p.L93F	TNFSF10_uc003fie.2_Intron	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	93	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CAGAGGTTCTCAAAATCATCT	0.313													0	0	0	0.007291	0	22	14										G	172229441	C	G	172229441	3	3	116	1	0	0	0	0	1	0	0	0	16298	825	29	1	578	1	TNFSF10	3	172229441	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4980475	172229441	25792989	78	34712										
PIK3CA	5290	broad.mit.edu	37	chr3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atcctctctctgaaatcactGagcaggagaaagattttcta	7	9	4	4	rs104886003		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.004878	0	30	50										A	178936091	G	A	178936091	3	1	116	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1667	1	PIK3CA	3	178936091	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	6706650	178936091	19086339	79	34713										
CHRD	8646	broad.mit.edu	37	chr3	184104518	184104518	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgggcgcccaactacgaccCgctctgctcactctgcacct	8	19	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:184104518C>T	uc003fov.2	+	16	2417	c.2171C>T	c.(2170-2172)CCG>CTG	p.P724L	CHRD_uc003fow.2_Missense_Mutation_p.P354L|CHRD_uc003fox.2_Missense_Mutation_p.P724L|CHRD_uc003foy.2_Missense_Mutation_p.P354L|CHRD_uc010hyc.2_Missense_Mutation_p.P314L|CHRD_uc011brr.1_Intron	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	724	VWFC 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AACTACGACCCGCTCTGCTCA	0.672													0	0	0	0.013537	0	12	16										T	184104518	C	T	184104518	3	4	116	1	0	0	0	0	1	0	0	0	3372	652	23	2	2233	2	CHRD	3	184104518	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5168427	184104518	13917912	80	34714										
DGKG	1608	broad.mit.edu	37	chr3	185985533	185985533	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtctctgagttccccaccgtCacacaacgttgataattcac	6	14	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:185985533C>T	uc003fqa.2	-	13	1687	c.1150G>A	c.(1150-1152)GAC>AAC	p.D384N	DGKG_uc003fqb.2_Missense_Mutation_p.D345N|DGKG_uc003fqc.2_Missense_Mutation_p.D384N|DGKG_uc011brx.1_Missense_Mutation_p.D345N	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	384	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TCCCCACCGTCACACAACGTT	0.522													0	0	0	0.01441	0	56	101										T	185985533	C	T	185985533	3	4	116	1	0	0	0	0	1	0	0	0	4469	826	29	1	1277	1	DGKG	3	185985533	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1881015	185985533	12036897	81	34715										
CPN2	1370	broad.mit.edu	37	chr3	194062300	194062300	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gttggtgtcgaagatgccctCcggaagtgtggtcagctggt	16	8	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr3:194062300C>T	uc003fts.2	-	2	1222	c.1132G>A	c.(1132-1134)GAG>AAG	p.E378K		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	378	LRR 12.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		AAGATGCCCTCCGGAAGTGTG	0.602													0	0	0	0.01441	0	52	76										T	194062300	C	T	194062300	3	4	116	1	0	0	0	0	1	0	0	0	3810	864	30	1	509	1	CPN2	3	194062300	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	8076767	194062300	3960130	82	34716										
SORCS2	57537	broad.mit.edu	37	chr4	7398029	7398029	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccacaggtgatcttgatcctGacgaagtactaccacgcaga	9	12	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:7398029G>C	uc003gkb.3	+	2	495	c.495G>C	c.(493-495)CTG>CTC	p.L165L	SORCS2_uc011bwi.1_5'UTR	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	165	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						TCTTGATCCTGACGAAGTACT	0.517													0	0	0	0.005443	0	18	35										C	7398029	G	C	7398029	2	2	116	1	0	0	0	0	0	0	0	1	14931	1277	45	1		1	SORCS2	4	7398029	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		7398029	183756247	83	34717										
TEC	7006	broad.mit.edu	37	chr4	48151605	48151605	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgcttatgatattcaataatCtcaggaatggagccaaaagc	8	7	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:48151605C>G	uc003gxz.2	-	11	1066	c.975G>C	c.(973-975)GAG>GAC	p.E325D		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	325	SH2.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						ATTCAATAATCTCAGGAATGG	0.343													0	0	0	0.000602	0	3	88										G	48151605	C	G	48151605	3	3	116	1	0	0	0	0	1	0	0	0	15739	912	32	1	952	1	TEC	4	48151605	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	40753576	48151605	143002671	84	34718										
KDR	3791	broad.mit.edu	37	chr4	55948135	55948135	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtcttacccaaaagatggaGataatttggttctgtcttcc	8	8	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:55948135G>A	uc003has.2	-	29	4138	c.3836C>T	c.(3835-3837)TCT>TTT	p.S1279F	KDR_uc003hat.1_Missense_Mutation_p.S1279F	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1279	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AAAAGATGGAGATAATTTGGT	0.388			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.001855	0	9	102										A	55948135	G	A	55948135	3	1	116	1	0	0	0	0	1	0	0	0	8139	942	33	1	242	1	KDR	4	55948135	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7796530	55948135	135206141	85	34719										
NAAA	27163	broad.mit.edu	37	chr4	76862017	76862017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agcgcggcgctgctgggggcGaggcggctgacagcccggcc	20	14	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:76862017G>A	uc003hjb.2	-	1	150	c.86C>T	c.(85-87)TCG>TTG	p.S29L	NAAA_uc003hja.2_Missense_Mutation_p.S29L|NAAA_uc003hjc.3_Missense_Mutation_p.S29L|NAAA_uc003hjd.3_RNA|NAAA_uc011cbq.1_5'Flank|NAAA_uc010iiz.1_Missense_Mutation_p.S29L	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	29					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						TGCTGGGGGCGAGGCGGCTGA	0.756													0	0	0	0.008291	0	10	6										A	76862017	G	A	76862017	3	1	116	1	0	0	0	0	1	0	0	0	10127	1059	37	1	1040	1	NAAA	4	76862017	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	20913882	76862017	114292259	86	34720										
HERC6	55008	broad.mit.edu	37	chr4	89361189	89361189	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcattggaaatactgattatGactggaaacagtttgaacag	9	5	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:89361189G>C	uc011cdi.1	+	21	2902	c.2719G>C	c.(2719-2721)GAC>CAC	p.D907H	HERC6_uc011cdj.1_Missense_Mutation_p.D871H|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	907	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TACTGATTATGACTGGAAACA	0.378													0	0	0	0.007291	0	22	31										C	89361189	G	C	89361189	3	2	116	1	0	0	0	0	1	0	0	0	7062	1290	45	1	2598	1	HERC6	4	89361189	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	12499172	89361189	101793087	87	34721										
FAM190A	401145	broad.mit.edu	37	chr4	91230198	91230198	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgctgatcttaccacagctCagacaccttcagaattttta	5	12	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:91230198C>G	uc003hsv.3	+	2	1103	c.763C>G	c.(763-765)CAG>GAG	p.Q255E	FAM190A_uc003hsu.3_Missense_Mutation_p.Q255E|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.Q255E	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	255										large_intestine(1)|ovary(1)	2						TACCACAGCTCAGACACCTTC	0.433													0	0	0	0.01441	0	49	61										G	91230198	C	G	91230198	3	3	116	1	0	0	0	0	1	0	0	0	5521	827	29	1	765	1	FAM190A	4	91230198	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1869009	91230198	99924078	88	34722										
BDH2	56898	broad.mit.edu	37	chr4	104003301	104003301	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcagttgcgaatcttcccgtCttttgtctcttcaggaaatc	8	11	4	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:104003301C>A	uc003hwz.2	-	9	726	c.621G>T	c.(619-621)AAG>AAT	p.K207N	BDH2_uc003hxa.2_RNA	NM_020139	NP_064524	Q9BUT1	BDH2_HUMAN	3-hydroxybutyrate dehydrogenase, type 2	207					fatty acid beta-oxidation|heme metabolic process|iron ion homeostasis|siderophore biosynthetic process	cytoplasm	3-hydroxybutyrate dehydrogenase activity|NAD binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.02e-08)		ATCTTCCCGTCTTTTGTCTCT	0.458													1	0	2.17888e-05	0.006214	2.2289e-05	8	85										A	104003301	C	A	104003301	3	1	116	1	0	0	0	0	1	0	0	0	1391	912	32	3	124	3	BDH2	4	104003301	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	12773103	104003301	87150975	89	34723										
TET2	54790	broad.mit.edu	37	chr4	106157401	106157401	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctcacccccaaagcaacaatGatcagcaaagagaaggatca	7	12	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:106157401G>C	uc003hxk.2	+	3	2688	c.2302G>C	c.(2302-2304)GAT>CAT	p.D768H	TET2_uc011cez.1_Missense_Mutation_p.D789H|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.D768H|TET2_uc003hxi.1_Missense_Mutation_p.D768H	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	768	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AAGCAACAATGATCAGCAAAG	0.383			Mis N|F		MDS								0	0	0	0.01441	0	42	54										C	106157401	G	C	106157401	3	2	116	1	0	0	0	0	1	0	0	0	15767	1290	45	1	2304	1	TET2	4	106157401	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2154100	106157401	84996875	90	34724			1	161		3	3	1015	G		6.739662e-05
TET2	54790	broad.mit.edu	37	chr4	106158369	106158369	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caaacaacttcttcagaaaaGacaccaaccaaaagaacagc	4	12	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:106158369G>C	uc003hxk.2	+	3	3656	c.3270G>C	c.(3268-3270)AAG>AAC	p.K1090N	TET2_uc011cez.1_Missense_Mutation_p.K1111N|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.K1090N|TET2_uc003hxi.1_Missense_Mutation_p.K1090N	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	1090					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.K1090fs*16(1)		haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CTTCAGAAAAGACACCAACCA	0.393			Mis N|F		MDS								0	0	0	0.003271	0	30	26										C	106158369	G	C	106158369	3	2	116	1	0	0	0	0	1	0	0	0	15767	933	33	1	3272	1	TET2	4	106158369	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	968	106158369	84995907	91	34725			1	161		3	3	1015	G		6.739662e-05
TET2	54790	broad.mit.edu	37	chr4	106158415	106158415	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgttctcaataattttataGagtcaccttccaaattacta	3	9	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:106158415G>C	uc003hxk.2	+	3	3702	c.3316G>C	c.(3316-3318)GAG>CAG	p.E1106Q	TET2_uc011cez.1_Missense_Mutation_p.E1127Q|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.E1106Q|TET2_uc003hxi.1_Missense_Mutation_p.E1106Q	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	1106					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TAATTTTATAGAGTCACCTTC	0.373			Mis N|F		MDS								0	0	0	0.00623	0	35	45										C	106158415	G	C	106158415	3	2	116	1	0	0	0	0	1	0	0	0	15767	943	33	1	3318	1	TET2	4	106158415	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	46	106158415	84995861	92	34726			1	161		3	3	1015	G		6.739662e-05
UCP1	7350	broad.mit.edu	37	chr4	141489036	141489036	+	Frame_Shift_Del	DEL	G	G	-													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cccgcaggcagcccgctgtaGagtttcatccgcccttctgt					rs17848358		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:141489036delG	uc011chj.1	-	2	298	c.222delC	c.(220-222)CTCfs	p.L74fs	UCP1_uc011chk.1_Frame_Shift_Del_p.L74fs	NM_021833	NP_068605	P25874	UCP1_HUMAN	uncoupling protein 1	74	Solcar 1.|Helical; Name=2; (Potential).				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	all_hematologic(180;0.162)					GCCCGCTGTAGAGTTTCATCC	0.567																		71	90	---	---								-	141489036	G	-	141489036	7	5	116	1	0	1	0	1	0	0	0	0	16927	929	33	0	719	0	UCP1	4	141489036	Frame_Shift_Del	DEL	G	TCGA-GV-A3JX-01A-11D-A20D-08	35330621	141489036	49665240	93	34727										
INPP4B	8821	broad.mit.edu	37	chr4	143045828	143045828	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcctgaaggagcacaaatgtCagggactgcttggctcggtt	13	9	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:143045828C>G	uc003iix.3	-	20	2401	c.1806G>C	c.(1804-1806)CTG>CTC	p.L602L	INPP4B_uc003iiw.3_Silent_p.L602L|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Silent_p.L417L|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Silent_p.L473L	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	602					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GCACAAATGTCAGGGACTGCT	0.537													0	0	0	0.013726	0	32	48										G	143045828	C	G	143045828	2	3	116	1	0	0	0	0	0	0	0	1	7753	813	29	1		1	INPP4B	4	143045828	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1556792	143045828	48108448	94	34728										
MAP9	79884	broad.mit.edu	37	chr4	156289749	156289749	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtgctaacctcaggatcaaGgttttcagagaatgcttttt	9	7	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:156289749G>C	uc003ios.2	-	5	961	c.697C>G	c.(697-699)CTT>GTT	p.L233V	MAP9_uc011cin.1_Missense_Mutation_p.L232V|MAP9_uc010iqa.1_RNA|MAP9_uc003iot.1_Missense_Mutation_p.L232V|MAP9_uc010iqb.1_Missense_Mutation_p.L160V	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	aster-associated protein	233					cell division|mitosis	cytoplasm|microtubule|spindle				ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		TCAGGATCAAGGTTTTCAGAG	0.378													0	0	0	0.003954	0	22	35										C	156289749	G	C	156289749	3	2	116	1	0	0	0	0	1	0	0	0	9270	1000	35	4	1286	4	MAP9	4	156289749	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	13243921	156289749	34864527	95	34729										
ANXA10	11199	broad.mit.edu	37	chr4	169108570	169108570	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttgccatctgtgctggtgaTgctgaggactactaaaatga	11	8	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:169108570T>C	uc003irm.2	+	12	1105	c.960T>C	c.(958-960)GAT>GAC	p.D320D	ANXA10_uc003irn.2_Silent_p.D192D	NM_007193	NP_009124	Q9UJ72	ANX10_HUMAN	annexin A10	320							calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		GTGCTGGTGATGCTGAGGACT	0.338													0	0	0	0.00874	0	32	42										C	169108570	T	C	169108570	2	2	116	1	0	0	0	0	0	0	0	1	715	1461	51	5		5	ANXA10	4	169108570	Silent	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	12818821	169108570	22045706	96	34730										
NEIL3	55247	broad.mit.edu	37	chr4	178274823	178274823	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtccagcacataaaaaaccGaaaacagcccaatactcatc	4	13	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:178274823G>A	uc003iut.2	+	8	1518	c.1401G>A	c.(1399-1401)CCG>CCA	p.P467P	NEIL3_uc010irs.2_3'UTR	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	467					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		ATAAAAAACCGAAAACAGCCC	0.353								BER_DNA_glycosylases					0	0	0	0.009718	0	35	51										A	178274823	G	A	178274823	2	1	116	1	0	0	0	0	0	0	0	1	10320	1045	37	1		1	NEIL3	4	178274823	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	9166253	178274823	12879453	97	34731										
ODZ3	55714	broad.mit.edu	37	chr4	183713719	183713719	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aattttatatgatagcacaaGagtcagttttacctatgatg	7	5	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr4:183713719G>A	uc003ivd.1	+	25	5931	c.5894G>A	c.(5893-5895)AGA>AAA	p.R1965K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1965	Extracellular (Potential).|YD 10.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GATAGCACAAGAGTCAGTTTT	0.418													0	0	0	0.01441	0	57	47										A	183713719	G	A	183713719	3	1	116	1	0	0	0	0	1	0	0	0	10836	942	33	1	5992	1	ODZ3	4	183713719	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5438896	183713719	7440557	98	34732										
PLEKHG4B	153478	broad.mit.edu	37	chr5	169623	169623	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggcaacttggagaagctccaCgacttccaccagcagcactt	9	14	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:169623C>T	uc003jak.2	+	12	2627	c.2577C>T	c.(2575-2577)CAC>CAT	p.H859H		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	859	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAGCTCCACGACTTCCACC	0.567													0	0	0	0.01441	0	62	163										T	169623	C	T	169623	2	4	116	1	0	0	0	0	0	0	0	1	12072	535	19	2		2	PLEKHG4B	5	169623	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		169623	180745637	99	34733										
CDH9	1007	broad.mit.edu	37	chr5	26988259	26988259	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgtgtactcttccaataagAagaactgattccacatccag	6	11	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:26988259A>G	uc003jgs.1	-	2	351	c.182T>C	c.(181-183)TTC>TCC	p.F61S	CDH9_uc010iug.2_Missense_Mutation_p.F61S	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	61	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTCCAATAAGAAGAACTGATT	0.383													0	0	0	0.007413	0	14	34										G	26988259	A	G	26988259	3	3	116	1	0	0	0	0	1	0	0	0	3117	246	9	5	2231	5	CDH9	5	26988259	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	26818636	26988259	153927001	100	34734										
RNASEN	29102	broad.mit.edu	37	chr5	31526792	31526792	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcgctgacggaggcatgggtGgggggaagggtacaaagtct	20	6	1	1	rs149389256	by1000genomes	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:31526792G>A	uc003jhg.2	-	4	607	c.248C>T	c.(247-249)CCA>CTA	p.P83L	RNASEN_uc003jhh.2_Missense_Mutation_p.P83L|RNASEN_uc003jhi.2_Missense_Mutation_p.P83L|RNASEN_uc010iui.1_Missense_Mutation_p.P74L	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	83	Pro-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						AGGCATGGGTGGGGGGAAGGG	0.577													0	0	0	0.004672	0	3	50										A	31526792	G	A	31526792	3	1	116	1	0	0	0	0	1	0	0	0	13417	1348	47	2	4004	2	RNASEN	5	31526792	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	4538533	31526792	149388468	101	34735										
PAIP1	10605	broad.mit.edu	37	chr5	43527531	43527531	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaacttttcataagcttcttCtatctctgggtccatctcat	4	11	5	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:43527531C>G	uc003job.2	-	11	1634	c.1387G>C	c.(1387-1389)GAA>CAA	p.E463Q	PAIP1_uc003joa.2_Missense_Mutation_p.E384Q|PAIP1_uc010ivp.2_Nonstop_Mutation_p.*352Y|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.E351Q	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	463	PABPC1-interacting motif-1 (PAM1).				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					TAAGCTTCTTCTATCTCTGGG	0.333													0	0	0	0.006214	0	7	98										G	43527531	C	G	43527531	3	3	116	1	0	0	0	0	1	0	0	0	11396	922	32	1	56	1	PAIP1	5	43527531	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	12000739	43527531	137387729	102	34736										
ISL1	3670	broad.mit.edu	37	chr5	50685565	50685565	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acccgcgtgcggactgtgctGaacgagaagcagctgcacac	13	13	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:50685565G>C	uc003jor.2	+	4	1112	c.564G>C	c.(562-564)CTG>CTC	p.L188L		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	188	Homeobox.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				GGACTGTGCTGAACGAGAAGC	0.667													0	0	0	0.004482	0	9	43										C	50685565	G	C	50685565	2	2	116	1	0	0	0	0	0	0	0	1	7856	1277	45	1		1	ISL1	5	50685565	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7158034	50685565	130229695	103	34737										
BDP1	55814	broad.mit.edu	37	chr5	70818248	70818248	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaaaaagtcacaacagatcaGagcaaggaaggcaagccaga	11	8	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:70818248G>C	uc003kbp.1	+	23	5387	c.5124G>C	c.(5122-5124)CAG>CAC	p.Q1708H	BDP1_uc003kbo.2_Missense_Mutation_p.Q1708H|BDP1_uc003kbq.1_Intron	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1708					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAACAGATCAGAGCAAGGAAG	0.388													0	0	0	0.00499	0	15	98										C	70818248	G	C	70818248	3	2	116	1	0	0	0	0	1	0	0	0	1395	933	33	1	5214	1	BDP1	5	70818248	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	20132683	70818248	110097012	104	34738										
BDP1	55814	broad.mit.edu	37	chr5	70820129	70820129	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cctgaacctgtttctgctcaGattgaggaaacaatggaaga	10	8	2	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:70820129G>C	uc003kbp.1	+	25	6014	c.5751G>C	c.(5749-5751)CAG>CAC	p.Q1917H	BDP1_uc003kbo.2_Missense_Mutation_p.Q1917H|BDP1_uc003kbq.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1917					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TTTCTGCTCAGATTGAGGAAA	0.383													0	0	0	0.008291	0	8	51										C	70820129	G	C	70820129	3	2	116	1	0	0	0	0	1	0	0	0	1395	933	33	1	5849	1	BDP1	5	70820129	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1881	70820129	110095131	105	34739										
MAN2A1	4124	broad.mit.edu	37	chr5	109026163	109026163	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgttcggcagtgcgatcttCtgtgtggtgattttctcgct	13	8	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:109026163C>G	uc003kou.1	+	1	1008	c.45C>G	c.(43-45)TTC>TTG	p.F15L	MAN2A1_uc003kot.1_RNA	NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	15	Helical; Signal-anchor for type II membrane protein; (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GTGCGATCTTCTGTGTGGTGA	0.582													0	0	0	0.006122	0	15	5										G	109026163	C	G	109026163	3	3	116	1	0	0	0	0	1	0	0	0	9214	912	32	1	47	1	MAN2A1	5	109026163	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	38206034	109026163	71889097	106	34740										
CAMK4	814	broad.mit.edu	37	chr5	110710590	110710590	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgagataggagttcttcttCgcctctcacatccaaacatt	6	12	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:110710590C>T	uc011cvj.1	+	4	382	c.283C>T	c.(283-285)CGC>TGC	p.R95C	CAMK4_uc003kpf.2_Missense_Mutation_p.R95C|CAMK4_uc010jbv.2_Intron	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	95	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AGTTCTTCTTCGCCTCTCACA	0.393													0	0	0	0.006214	0	9	33										T	110710590	C	T	110710590	3	4	116	1	0	0	0	0	1	0	0	0	2605	884	31	1	293	1	CAMK4	5	110710590	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1684427	110710590	70204670	107	34741										
ACSL6	23305	broad.mit.edu	37	chr5	131307298	131307298	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgttggtgatgctggggctGctccagtaacaatcatccgc	12	11	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:131307298G>A	uc010jdo.1	-	14	1387	c.1304C>T	c.(1303-1305)GCA>GTA	p.A435V	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Missense_Mutation_p.A460V|ACSL6_uc003kvy.1_Missense_Mutation_p.A460V|ACSL6_uc003kwb.2_Missense_Mutation_p.A425V|ACSL6_uc003kvz.1_Missense_Mutation_p.A360V|ACSL6_uc003kwa.1_Missense_Mutation_p.A446V|ACSL6_uc003kvw.1_Missense_Mutation_p.A81V|ACSL6_uc010jdn.1_Missense_Mutation_p.A450V	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	435	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGCTGGGGCTGCTCCAGTAAC	0.522													0	0	0	0.00278	0	19	3										A	131307298	G	A	131307298	3	1	116	1	0	0	0	0	1	0	0	0	181	1319	46	2	821	2	ACSL6	5	131307298	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	20596708	131307298	49607962	108	34742										
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	chr5	139917031	139917031	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtcagtgccagtcaagatcGaaagatacctcccccaattg	8	12	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:139917031G>A	uc003lfs.1	+	31	7209	c.7085G>A	c.(7084-7086)CGA>CAA	p.R2362Q	ANKHD1_uc003lfr.2_Missense_Mutation_p.R2362Q|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R1118Q|ANKHD1_uc003lfw.2_Missense_Mutation_p.R1017Q|ANKHD1_uc010jfl.2_Missense_Mutation_p.R738Q|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.R516Q	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2362						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCAAGATCGAAAGATACCT	0.547													0	0	0	0.01441	0	44	27										A	139917031	G	A	139917031	3	1	116	1	0	0	0	0	1	0	0	0	629	1058	37	1	7207	1	ANKHD1-EIF4EBP3	5	139917031	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	8609733	139917031	40998229	109	34743										
PCDHB7	56129	broad.mit.edu	37	chr5	140553317	140553317	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcaatccaacatctggcagtCttcatcttaaagcgcaattg	6	11	5	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:140553317C>T	uc003lit.2	+	1	1075	c.901C>T	c.(901-903)CTT>TTT	p.L301F		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	301	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L301P(1)		ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATCTGGCAGTCTTCATCTTAA	0.408													0	0	0	0.01441	0	73	12										T	140553317	C	T	140553317	3	4	116	1	0	0	0	0	1	0	0	0	11547	913	32	1	903	1	PCDHB7	5	140553317	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	636286	140553317	40361943	110	34744										
PCDHGB3	56102	broad.mit.edu	37	chr5	140750463	140750463	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atgtaggtgtcaattcgctgCagcagtactacctcagccct	9	12	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:140750463C>T	uc003ljw.1	+	1	502	c.502C>T	c.(502-504)CAG>TAG	p.Q168*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Nonsense_Mutation_p.Q168*	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	168	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATTCGCTGCAGCAGTACTA	0.512													0	0	0	0.001855	0	9	214										T	140750463	C	T	140750463	4	4	116	1	0	0	0	0	0	1	0	0	11564	711	25	2	504	2	PCDHGB3	5	140750463	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	197146	140750463	40164797	111	34745										
FAT2	2196	broad.mit.edu	37	chr5	150925437	150925437	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cataggagcattgtcattttCatcaattatgtcaaccacca	5	10	4	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:150925437C>A	uc003lue.3	-	9	5264	c.5251G>T	c.(5251-5253)GAA>TAA	p.E1751*	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1751	Cadherin 15.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGTCATTTTCATCAATTATG	0.408													1	0	5.35267e-07	0.007413	5.53201e-07	18	147										A	150925437	C	A	150925437	4	1	116	1	0	0	0	0	0	1	0	0	5690	835	29	3	7858	3	FAT2	5	150925437	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	10174974	150925437	29989823	112	34746										
PANK3	79646	broad.mit.edu	37	chr5	167991021	167991021	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagagcctcttcaaaactttCacagccagtcaataaactgc	5	12	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:167991021C>T	uc003lzz.1	-	4	985	c.685G>A	c.(685-687)GAA>AAA	p.E229K		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	229					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		TCAAAACTTTCACAGCCAGTC	0.383													0	0	0	0.013726	0	25	173										T	167991021	C	T	167991021	3	4	116	1	0	0	0	0	1	0	0	0	11418	835	29	1	443	1	PANK3	5	167991021	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	17065584	167991021	12924239	113	34747										
ZNF354A	6940	broad.mit.edu	37	chr5	178152427	178152427	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccacctcccagggatcttctCcttgctgcaacagggagatc	9	15	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:178152427C>G	uc003mjj.2	-	4	404	c.206G>C	c.(205-207)GGA>GCA	p.G69A		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	69	KRAB.				regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		GGGATCTTCTCCTTGCTGCAA	0.493													0	0	0	0.008361	0	21	133										G	178152427	C	G	178152427	3	3	116	1	0	0	0	0	1	0	0	0	17861	855	30	1	1619	1	ZNF354A	5	178152427	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	10161406	178152427	2762833	114	34748										
RUFY1	80230	broad.mit.edu	37	chr5	178977723	178977723	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cccggcccaggcgacctgcgGagcgcaacgaggccgcgggc	17	17	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr5:178977723G>A	uc003mka.1	+	1	153	c.153G>A	c.(151-153)CGG>CGA	p.R51R		NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	51					endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGACCTGCGGAGCGCAACGA	0.652										HNSCC(44;0.11)			0	0	0	0.008291	0	7	1										A	178977723	G	A	178977723	2	1	116	1	0	0	0	0	0	0	0	1	13738	1161	41	1		1	RUFY1	5	178977723	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	825296	178977723	1937537	115	34749										
DTNBP1	84062	broad.mit.edu	37	chr6	15523430	15523430	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctggagggtaatctcattctGacaggtactggattcaggcc	12	9	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:15523430G>C	uc003nbm.2	-	10	1003	c.832C>G	c.(832-834)CAG>GAG	p.Q278E	DTNBP1_uc003nbl.2_Missense_Mutation_p.Q197E|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	278	Dysbindin.				actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			ATCTCATTCTGACAGGTACTG	0.488									Hermansky-Pudlak_syndrome				0	0	0	0.001168	0	4	185										C	15523430	G	C	15523430	3	2	116	1	0	0	0	0	1	0	0	0	4790	1299	45	1	227	1	DTNBP1	6	15523430	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		15523430	155591637	116	34750										
HIST1H3H	8357	broad.mit.edu	37	chr6	27778040	27778040	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagtccaccgagctgctgatCagaaagctgccttttcagcg	10	12	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:27778040C>G	uc003njm.2	+	1	199	c.189C>G	c.(187-189)ATC>ATG	p.I63M	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	63					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AGCTGCTGATCAGAAAGCTGC	0.617													0	0	0	0.001168	0	4	71										G	27778040	C	G	27778040	3	3	116	1	0	0	0	0	1	0	0	0	7162	816	29	1	191	1	HIST1H3H	6	27778040	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	12254610	27778040	143337027	117	34751										
BAT2	7916	broad.mit.edu	37	chr6	31602332	31602332	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttgaggatgtggctggcacaGaagtgagtgagggtgggagg	21	3	0	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:31602332G>C	uc003nvb.3	+	20	5182	c.4933G>C	c.(4933-4935)GAA>CAA	p.E1645Q	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.E1645Q	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1645	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GGCTGGCACAGAAGTGAGTGA	0.582													0	0	0	0.00278	0	20	3										C	31602332	G	C	31602332	3	2	116	1	0	0	0	0	1	0	0	0	1319	943	33	1	5007	1	BAT2	6	31602332	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3824292	31602332	139512735	118	34752										
EHMT2	10919	broad.mit.edu	37	chr6	31855876	31855876	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggacaggggtgggggtgcagGagctgcagtgccggccggtg	23	8	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:31855876G>C	uc003nxz.1	-	13	1697	c.1687C>G	c.(1687-1689)CCT>GCT	p.P563A	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.P354A|EHMT2_uc011don.1_Missense_Mutation_p.P586A|EHMT2_uc003nya.1_Missense_Mutation_p.P529A	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	563					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGGGGTGCAGGAGCTGCAGTG	0.652													0	0	0	0.004672	0	3	22										C	31855876	G	C	31855876	3	2	116	1	0	0	0	0	1	0	0	0	4984	1174	41	1	2009	1	EHMT2	6	31855876	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	253544	31855876	139259191	119	34753										
PBX2	5089	broad.mit.edu	37	chr6	32156277	32156277	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcctgggagctccgaatgctGaggcctagcatgcaggcgag	15	11	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:32156277G>A	uc003oav.1	-	3	571	c.300C>T	c.(298-300)CTC>CTT	p.L100L	PBX2_uc003oaw.2_Silent_p.L100L	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	100							transcription factor binding			ovary(1)	1						TCCGAATGCTGAGGCCTAGCA	0.617													0	0	0	0.009535	0	25	5										A	32156277	G	A	32156277	2	1	116	1	0	0	0	0	0	0	0	1	11493	1277	45	1		1	PBX2	6	32156277	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	300401	32156277	138958790	120	34754										
CDKN1A	1026	broad.mit.edu	37	chr6	36652112	36652113	+	Frame_Shift_Ins	INS	-	-	C													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcctgcccaagctctaccttINScccacggggccccggcgagg							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:36652112_36652113insC	uc003omm.3	+	2	356_357	c.234_235insC	c.(232-237)CTTCCCfs	p.L78fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.L112fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.L78fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.L78fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	78_79					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						AGCTCTACCTTCCCACGGGGCC	0.663									Multiple_Endocrine_Neoplasia_type_1									29	7	---	---								C	36652113	-	C	36652112	7	5	116	1	0	1	1	0	0	0	0	0	3158	1770	62	0	236	0	CDKN1A	6	36652112	Frame_Shift_Ins	INS	-	TCGA-GV-A3JX-01A-11D-A20D-08	4495835	36652112	134462955	121	34755										
REV3L	5980	broad.mit.edu	37	chr6	111697267	111697267	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tatttagtccactttcatcaGcagtgctattaagagaatgc	7	8	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:111697267G>T	uc003puy.3	-	13	2614	c.2291C>A	c.(2290-2292)GCT>GAT	p.A764D	REV3L_uc003pux.3_Missense_Mutation_p.A686D|REV3L_uc003puz.3_Missense_Mutation_p.A686D	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	764					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ACTTTCATCAGCAGTGCTATT	0.368								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					1	0	1.14069e-49	0.01441	1.23961e-49	96	17										T	111697267	G	T	111697267	3	4	116	1	0	0	0	0	1	0	0	0	13240	971	34	4	7181	4	REV3L	6	111697267	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	75045155	111697267	59417800	122	34756			2	162		3	3	345	G		7.781667e-06
REV3L	5980	broad.mit.edu	37	chr6	111697396	111697396	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcctttttcatttccttcaGaggatactttattttttgaa	4	7	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:111697396G>C	uc003puy.3	-	13	2485	c.2162C>G	c.(2161-2163)TCT>TGT	p.S721C	REV3L_uc003pux.3_Missense_Mutation_p.S643C|REV3L_uc003puz.3_Missense_Mutation_p.S643C	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	721					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATTTCCTTCAGAGGATACTTT	0.353								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	50	7										C	111697396	G	C	111697396	3	2	116	1	0	0	0	0	1	0	0	0	13240	942	33	1	7310	1	REV3L	6	111697396	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	129	111697396	59417671	123	34757			2	162		3	3	345	G		7.781667e-06
REV3L	5980	broad.mit.edu	37	chr6	111697611	111697611	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcacaggaagatactgggagGatctctttcttactattctc	8	9	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:111697611G>A	uc003puy.3	-	13	2270	c.1947C>T	c.(1945-1947)ATC>ATT	p.I649I	REV3L_uc003pux.3_Silent_p.I571I|REV3L_uc003puz.3_Silent_p.I571I	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	649					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		ATACTGGGAGGATCTCTTTCT	0.313								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00333	0	23	2										A	111697611	G	A	111697611	2	1	116	1	0	0	0	0	0	0	0	1	13240	1164	41	1		1	REV3L	6	111697611	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	215	111697611	59417456	124	34758			2	162		3	3	345	G		7.781667e-06
LAMA2	3908	broad.mit.edu	37	chr6	129777521	129777521	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttctgtgagagccctggatgGacccaaagccagcattgtgc	12	11	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr6:129777521G>A	uc003qbn.2	+	47	6854	c.6749G>A	c.(6748-6750)GGA>GAA	p.G2250E	LAMA2_uc003qbo.2_Missense_Mutation_p.G2250E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2250	Laminin G-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCCCTGGATGGACCCAAAGCC	0.478													0	0	0	0.01441	0	104	26										A	129777521	G	A	129777521	3	1	116	1	0	0	0	0	1	0	0	0	8606	1174	41	1	6939	1	LAMA2	6	129777521	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	18079910	129777521	41337546	125	34759										
CARD11	84433	broad.mit.edu	37	chr7	2978453	2978453	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttgtctgagtctggcaggcTgcgcttcccggcctgggtgg	16	12	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:2978453T>A	uc003smv.2	-	7	1281	c.877A>T	c.(877-879)AGC>TGC	p.S293C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	293	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCTGGCAGGCTGCGCTTCCCG	0.632			Mis		DLBCL								0	0	0	0.000602	0	4	84										A	2978453	T	A	2978453	3	1	116	1	0	0	0	0	1	0	0	0	2645	1580	55	5	2663	5	CARD11	7	2978453	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08		2978453	156160210	126	34760										
ACTB	60	broad.mit.edu	37	chr7	5568878	5568878	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctcgggagccacacgcagctCattgtagaaggtgtggtgcc	14	11	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:5568878C>G	uc003sos.3	-	2	313	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	ACTB_uc003sor.3_5'UTR|ACTB_uc003sot.3_Missense_Mutation_p.E93Q|ACTB_uc003soq.3_5'UTR|ACTB_uc010ksy.2_Intron	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	93					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		ACACGCAGCTCATTGTAGAAG	0.617													0	0	0	0.001168	0	5	94										G	5568878	C	G	5568878	3	3	116	1	0	0	0	0	1	0	0	0	193	835	29	1	866	1	ACTB	7	5568878	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2590425	5568878	153569785	127	34761										
DNAH11	8701	broad.mit.edu	37	chr7	21934388	21934388	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atattctcattcgggaaataCgtatatcacttgaacaactg	6	8	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:21934388C>T	uc003svc.2	+	79	12950	c.12919C>T	c.(12919-12921)CGT>TGT	p.R4307C		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4307					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCGGGAAATACGTATATCACT	0.368									Kartagener_syndrome				0	0	0	0.008291	0	11	10										T	21934388	C	T	21934388	3	4	116	1	0	0	0	0	1	0	0	0	4599	536	19	2	13230	2	DNAH11	7	21934388	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16365510	21934388	137204275	128	34762										
C7orf30	115416	broad.mit.edu	37	chr7	23340550	23340550	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgtgatccaggttcctccaGaaatgagatatacagattac	9	8	0	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:23340550G>C	uc003swd.1	+	2	381	c.349G>C	c.(349-351)GAA>CAA	p.E117Q		NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	117						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)			GGTTCCTCCAGAAATGAGATA	0.408													0	0	0	0.01441	0	112	133										C	23340550	G	C	23340550	3	2	116	1	0	0	0	0	1	0	0	0	2386	943	33	1	355	1	C7orf30	7	23340550	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1406162	23340550	135798113	129	34763										
PDE1C	5137	broad.mit.edu	37	chr7	31890295	31890295	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gttggtggttccggtatgctCgtagtcatggatggcagctg	16	7	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:31890295C>T	uc003tcm.1	-	8	1280	c.811G>A	c.(811-813)GAG>AAG	p.E271K	PDE1C_uc003tcn.1_Missense_Mutation_p.E271K|PDE1C_uc003tco.1_Missense_Mutation_p.E331K|PDE1C_uc003tcr.2_Missense_Mutation_p.E271K|PDE1C_uc003tcs.2_Missense_Mutation_p.E271K	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	271	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CCGGTATGCTCGTAGTCATGG	0.443													0	0	0	0.003163	0	11	156										T	31890295	C	T	31890295	3	4	116	1	0	0	0	0	1	0	0	0	11635	893	31	1	1133	1	PDE1C	7	31890295	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	8549745	31890295	127248368	130	34764										
EPDR1	54749	broad.mit.edu	37	chr7	37960519	37960519	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttgggcttgggcttgccctCgggccggggaaggctgaccg	18	12	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:37960519C>T	uc003tfp.2	+	1	357	c.338C>T	c.(337-339)TCG>TTG	p.S113L	EPDR1_uc003tfq.2_Missense_Mutation_p.S113L|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	Error:Variant_position_missing_in_Q9UM22_after_alignment					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GGCTTGCCCTCGGGCCGGGGA	0.736													0	0	0	0.013537	0	12	11										T	37960519	C	T	37960519	3	4	116	1	0	0	0	0	1	0	0	0	5163	893	31	1	340	1	EPDR1	7	37960519	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	6070224	37960519	121178144	131	34765										
DDC	1644	broad.mit.edu	37	chr7	50531017	50531017	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggcagattccaccgtgcgaGaacagatggcaaagcgcagg	15	10	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:50531017G>A	uc003tpf.3	-	14	1441	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	DDC_uc010kza.2_Missense_Mutation_p.S367F|DDC_uc003tpg.3_Missense_Mutation_p.S452F	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	452					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CACCGTGCGAGAACAGATGGC	0.537													0	0	0	0.003271	0	30	30										A	50531017	G	A	50531017	3	1	116	1	0	0	0	0	1	0	0	0	4325	942	33	1	91	1	DDC	7	50531017	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	12570498	50531017	108607646	132	34766										
COBL	23242	broad.mit.edu	37	chr7	51095966	51095966	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggggctcccactgccaaatCttccccgtggttgttgggag	13	12	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:51095966C>T	uc003tpr.3	-	10	3012	c.2827G>A	c.(2827-2829)GAT>AAT	p.D943N	COBL_uc003tps.2_Missense_Mutation_p.D1000N|COBL_uc011kcl.1_Missense_Mutation_p.D943N|COBL_uc003tpp.3_Missense_Mutation_p.D729N|COBL_uc003tpq.3_Missense_Mutation_p.D884N|COBL_uc003tpo.3_Missense_Mutation_p.D485N	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	943										skin(3)|ovary(2)	5	Glioma(55;0.08)					ACTGCCAAATCTTCCCCGTGG	0.562													0	0	0	0.000602	0	4	93										T	51095966	C	T	51095966	3	4	116	1	0	0	0	0	1	0	0	0	3653	913	32	1	974	1	COBL	7	51095966	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	564949	51095966	108042697	133	34767										
SEMA3D	223117	broad.mit.edu	37	chr7	84671602	84671602	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cgttgtcctcctacatcattCtgacatgaaaaaaaaaataa	4	9	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:84671602C>G	uc003uic.2	-	8	902	c.862_splice	c.e8-1	p.N288_splice	SEMA3D_uc010led.2_Splice_Site_p.N288_splice|SEMA3D_uc003uib.2_5'Flank	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CTACATCATTCTGACATGAAA	0.373													0	0	0	0.01441	0	86	97										G	84671602	C	G	84671602	5	3	116	1	0	0	0	0	0	0	1	0	14027	927	32	1	1512	1	SEMA3D	7	84671602	Splice_Site	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	33575636	84671602	74467061	134	34768										
ADAM22	53616	broad.mit.edu	37	chr7	87760697	87760697	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atcaccctacgtgagtttatGaaatacaggagggattttat	9	6	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:87760697G>C	uc003ujn.2	+	11	1018	c.939G>C	c.(937-939)ATG>ATC	p.M313I	ADAM22_uc003ujj.1_Missense_Mutation_p.M313I|ADAM22_uc003ujk.1_Missense_Mutation_p.M313I|ADAM22_uc003ujl.1_Missense_Mutation_p.M313I|ADAM22_uc003ujm.2_Missense_Mutation_p.M313I|ADAM22_uc003ujo.2_Missense_Mutation_p.M313I|ADAM22_uc003ujp.1_Missense_Mutation_p.M365I	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	313	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GTGAGTTTATGAAATACAGGA	0.363													0	0	0	0.000602	0	3	88										C	87760697	G	C	87760697	3	2	116	1	0	0	0	0	1	0	0	0	244	1290	45	1	981	1	ADAM22	7	87760697	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3089095	87760697	71377966	135	34769										
ANKIB1	54467	broad.mit.edu	37	chr7	91972349	91972349	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttctttaagactgggacaggGagaaattacttgaagcttgg	12	5	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:91972349G>C	uc003ulw.2	+	6	1175	c.799G>C	c.(799-801)GAG>CAG	p.E267Q		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	267							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGGGACAGGGAGAAATTACT	0.383													0	0	0	0.008291	0	10	155										C	91972349	G	C	91972349	3	2	116	1	0	0	0	0	1	0	0	0	630	1175	41	1	817	1	ANKIB1	7	91972349	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	4211652	91972349	67166314	136	34770										
MET	4233	broad.mit.edu	37	chr7	116398529	116398529	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcagtgtgtcaaacagtattCttgaatgttataccccagcc	7	10	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:116398529C>G	uc003vij.2	+	9	2306	c.2119C>G	c.(2119-2121)CTT>GTT	p.L707V	MET_uc010lkh.2_Missense_Mutation_p.L707V|MET_uc011kng.1_Missense_Mutation_p.L707V|MET_uc011knh.1_Missense_Mutation_p.L707V|MET_uc011kni.1_Missense_Mutation_p.L707V|MET_uc011knj.1_Missense_Mutation_p.L277V	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	707	Extracellular (Potential).|IPT/TIG 2.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			AAACAGTATTCTTGAATGTTA	0.328			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.009096	0	4	111										G	116398529	C	G	116398529	3	3	116	1	0	0	0	0	1	0	0	0	9485	913	32	1	2149	1	MET	7	116398529	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	24426180	116398529	42740134	137	34771										
MET	4233	broad.mit.edu	37	chr7	116398545	116398545	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tattcttgaatgttatacccCagcccaaaccatttcaactg	4	12	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:116398545C>G	uc003vij.2	+	9	2322	c.2135C>G	c.(2134-2136)CCA>CGA	p.P712R	MET_uc010lkh.2_Missense_Mutation_p.P712R|MET_uc011kng.1_Missense_Mutation_p.P712R|MET_uc011knh.1_Missense_Mutation_p.P712R|MET_uc011kni.1_Missense_Mutation_p.P712R|MET_uc011knj.1_Missense_Mutation_p.P282R	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	712	Extracellular (Potential).|IPT/TIG 2.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGTTATACCCCAGCCCAAACC	0.338			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.001168	0	4	123										G	116398545	C	G	116398545	3	3	116	1	0	0	0	0	1	0	0	0	9485	594	21	4	2165	4	MET	7	116398545	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16	116398545	42740118	138	34772										
C7orf58	79974	broad.mit.edu	37	chr7	120906763	120906763	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tttctttctgaatttcagatCacgtcccctagagaatactg	6	10	4	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:120906763C>T	uc003vjq.3	+	20	2981	c.2534C>T	c.(2533-2535)TCA>TTA	p.S845L		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	845						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AATTTCAGATCACGTCCCCTA	0.403													0	0	0	0.001984	0	5	87										T	120906763	C	T	120906763	3	4	116	1	0	0	0	0	1	0	0	0	2405	838	29	1	2654	1	C7orf58	7	120906763	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4508218	120906763	38231900	139	34773										
AKR1B10	57016	broad.mit.edu	37	chr7	134216707	134216707	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttgtgaggaaagcctttgaGaagaccctcaaggacctgaa	11	9	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:134216707G>C	uc003vrr.2	+	3	602	c.282G>C	c.(280-282)GAG>GAC	p.E94D		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	94					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						AAGCCTTTGAGAAGACCCTCA	0.468													0	0	0	0.004482	0	8	136										C	134216707	G	C	134216707	3	2	116	1	0	0	0	0	1	0	0	0	467	933	33	1	292	1	AKR1B10	7	134216707	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	13309944	134216707	24921956	140	34774										
CUL1	8454	broad.mit.edu	37	chr7	148484180	148484180	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	accagaacagtgcaagtgacGatgccgaagccagcatgatc	11	11	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:148484180G>A	uc010lpg.2	+	13	1973	c.1447G>A	c.(1447-1449)GAT>AAT	p.D483N	CUL1_uc003wey.2_Missense_Mutation_p.D483N|CUL1_uc003wez.2_Missense_Mutation_p.D373N|CUL1_uc003wfa.2_Missense_Mutation_p.D144N	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	483					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGCAAGTGACGATGCCGAAGC	0.413													0	0	0	0.01441	0	47	41										A	148484180	G	A	148484180	3	1	116	1	0	0	0	0	1	0	0	0	4054	1058	37	1	1493	1	CUL1	7	148484180	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	14267473	148484180	10654483	141	34775										
KCNH2	3757	broad.mit.edu	37	chr7	150649632	150649632	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggggtggctgaccacctcctCgttggcattgacgtaggtgg	16	10	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:150649632C>T	uc003wic.2	-	6	1451	c.1438G>A	c.(1438-1440)GAG>AAG	p.E480K	KCNH2_uc003wib.2_Missense_Mutation_p.E140K|KCNH2_uc011kux.1_Missense_Mutation_p.E384K|KCNH2_uc003wid.2_Missense_Mutation_p.E140K|KCNH2_uc003wie.2_Missense_Mutation_p.E480K	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	480	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity	p.E480E(1)		skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	ACCACCTCCTCGTTGGCATTG	0.597													0	0	0	0.004482	0	7	121										T	150649632	C	T	150649632	3	4	116	1	0	0	0	0	1	0	0	0	8032	893	31	1	2350	1	KCNH2	7	150649632	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2165452	150649632	8489031	142	34776										
GALNTL5	168391	broad.mit.edu	37	chr7	151699831	151699831	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgttcctggacagccactgtGaggtgaacagagtatggctg	14	8	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:151699831G>A	uc003wkp.2	+	6	914	c.691G>A	c.(691-693)GAG>AAG	p.E231K	GALNTL5_uc003wkq.2_5'UTR|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.E120K	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	231	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		CAGCCACTGTGAGGTGAACAG	0.502													0	0	0	0.00623	0	36	39										A	151699831	G	A	151699831	3	1	116	1	0	0	0	0	1	0	0	0	6224	1291	45	1	709	1	GALNTL5	7	151699831	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1050199	151699831	7438832	143	34777										
MLL3	58508	broad.mit.edu	37	chr7	151949650	151949650	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccttttgcacatattacaatGaagcatgtctttctgcaatt	5	9	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr7:151949650G>T	uc003wla.2	-	10	1669	c.1450C>A	c.(1450-1452)CAT>AAT	p.H484N		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	484	DHHC-type.|PHD-type 3.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATATTACAATGAAGCATGTCT	0.368			N		medulloblastoma								1	0	6.02846e-25	0.003271	6.44643e-25	28	33										T	151949650	G	T	151949650	3	4	116	1	0	0	0	0	1	0	0	0	9622	1290	45	3	13485	3	MLL3	7	151949650	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	249819	151949650	7189013	144	34778										
DUSP26	78986	broad.mit.edu	37	chr8	33454844	33454844	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atagaggcctggccagacctCgtcggcatggttacaggctg	14	11	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:33454844C>T	uc003xjp.2	-	2	523	c.190G>A	c.(190-192)GAG>AAG	p.E64K	DUSP26_uc003xjq.2_Missense_Mutation_p.E64K	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	64	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		GGCCAGACCTCGTCGGCATGG	0.557													0	0	0	0.001855	0	12	2										T	33454844	C	T	33454844	3	4	116	1	0	0	0	0	1	0	0	0	4823	893	31	1	457	1	DUSP26	8	33454844	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		33454844	112909178	145	34779										
PRKDC	5591	broad.mit.edu	37	chr8	48761858	48761858	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agcagaaagaacacagcattCatgaacctggcggggaaggg	14	8	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:48761858C>A	uc003xqi.2	-	55	7194	c.7137G>T	c.(7135-7137)ATG>ATT	p.M2379I	PRKDC_uc003xqj.2_Missense_Mutation_p.M2379I|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2379					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ACACAGCATTCATGAACCTGG	0.542								NHEJ					1	0	1.15088e-07	0.004007	1.19251e-07	14	132										A	48761858	C	A	48761858	3	1	116	1	0	0	0	0	1	0	0	0	12521	826	29	3	5381	3	PRKDC	8	48761858	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	15307014	48761858	97602164	146	34780										
NSMAF	8439	broad.mit.edu	37	chr8	59522183	59522183	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cgggtagccgttgaggggctGaaaatacaggtttgtgtccg	16	7	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:59522183G>A	uc003xtt.2	-	10	881	c.667C>T	c.(667-669)CAG>TAG	p.Q223*	NSMAF_uc011lee.1_Nonsense_Mutation_p.Q254*|NSMAF_uc003xtu.2_Nonsense_Mutation_p.Q223*	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	223	GRAM.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				TTGAGGGGCTGAAAATACAGG	0.532													0	0	0	0.004289	0	31	37										A	59522183	G	A	59522183	4	1	116	1	0	0	0	0	0	1	0	0	10674	1299	45	1	2174	1	NSMAF	8	59522183	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	10760325	59522183	86841839	147	34781										
KCNB2	9312	broad.mit.edu	37	chr8	73849046	73849046	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggactccgccgacgataatCacctgtcgccaagccggtgg	12	14	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:73849046C>G	uc003xzb.2	+	3	2044	c.1456C>G	c.(1456-1458)CAC>GAC	p.H486D		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	486	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CGACGATAATCACCTGTCGCC	0.512													0	0	0	0.004007	0	16	163										G	73849046	C	G	73849046	3	3	116	1	0	0	0	0	1	0	0	0	8013	826	29	1	1462	1	KCNB2	8	73849046	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	14326863	73849046	72514976	148	34782										
PI15	51050	broad.mit.edu	37	chr8	75761397	75761397	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atataaagtaggggtaccatGttcatcttgtcctccaagtt	8	8	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:75761397G>T	uc003yal.2	+	6	865	c.686G>T	c.(685-687)TGT>TTT	p.C229F	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.C229F	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	229						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GGGGTACCATGTTCATCTTGT	0.393													1	0	4.4782e-45	0.01441	4.8273e-45	78	100										T	75761397	G	T	75761397	3	4	116	1	0	0	0	0	1	0	0	0	11868	1377	48	4	704	4	PI15	8	75761397	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1912351	75761397	70602625	149	34783										
MMP16	4325	broad.mit.edu	37	chr8	89180039	89180039	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gctgtccccatggaaaccagAtgcaaaaataatggttatat	8	8	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:89180039A>T	uc003yeb.3	-	4	850	c.568T>A	c.(568-570)TCT>ACT	p.S190T	MMP16_uc003yec.2_Missense_Mutation_p.S190T	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	190	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGGAAACCAGATGCAAAAATA	0.438													0	0	0	0.006999	0	37	36										T	89180039	A	T	89180039	3	4	116	1	0	0	0	0	1	0	0	0	9655	333	12	5	1439	5	MMP16	8	89180039	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	13418642	89180039	57183983	150	34784										
UBR5	51366	broad.mit.edu	37	chr8	103358508	103358508	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgtatcatccccatcatctCcatcttcatcatcccggcta	3	17	6	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:103358508C>T	uc003ykr.1	-	7	725	c.692G>A	c.(691-693)GGA>GAA	p.G231E	UBR5_uc003yks.1_Missense_Mutation_p.G231E	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	231					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CCCATCATCTCCATCTTCATC	0.433													0	0	0	0.01441	0	84	197										T	103358508	C	T	103358508	3	4	116	1	0	0	0	0	1	0	0	0	16902	855	30	1	7919	1	UBR5	8	103358508	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	14178469	103358508	43005514	151	34785										
UBR5	51366	broad.mit.edu	37	chr8	103358578	103358578	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagatttgttctctgaagttCtcgaataatgacacttctgg	8	7	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:103358578C>T	uc003ykr.1	-	7	655	c.622G>A	c.(622-624)GAA>AAA	p.E208K	UBR5_uc003yks.1_Missense_Mutation_p.E208K	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	208					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTCTGAAGTTCTCGAATAATG	0.353													0	0	0	0.01441	0	46	90										T	103358578	C	T	103358578	3	4	116	1	0	0	0	0	1	0	0	0	16902	922	32	1	7989	1	UBR5	8	103358578	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	70	103358578	43005444	152	34786										
UBR5	51366	broad.mit.edu	37	chr8	103373849	103373849	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcagcttctcagaaacttctCgtaacctttaaaacaaaaca	3	11	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:103373849C>T	uc003ykr.1	-	2	101	c.68G>A	c.(67-69)CGA>CAA	p.R23Q	UBR5_uc003yks.1_Missense_Mutation_p.R23Q	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	23					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AGAAACTTCTCGTAACCTTTA	0.269													0	0	0	0.005443	0	24	40										T	103373849	C	T	103373849	3	4	116	1	0	0	0	0	1	0	0	0	16902	884	31	1	8563	1	UBR5	8	103373849	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	15271	103373849	42990173	153	34787										
DPYS	1807	broad.mit.edu	37	chr8	105436556	105436556	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcttggatagagattaaaaAttttggctgcatttgtgctg	10	4	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:105436556A>C	uc003yly.3	-	7	1283	c.1154T>G	c.(1153-1155)ATT>AGT	p.I385S		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	385					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGATTAAAAATTTTGGCTGC	0.353													0	0	0	0.010818	0	30	42										C	105436556	A	C	105436556	3	2	116	1	0	0	0	0	1	0	0	0	4746	101	4	5	417	5	DPYS	8	105436556	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	2062707	105436556	40927466	154	34788										
LRP12	29967	broad.mit.edu	37	chr8	105509596	105509596	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggcaatgccaatacccatcaCaacgctgctgctcagtataa	7	13	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:105509596C>T	uc003yma.2	-	5	1279	c.1184G>A	c.(1183-1185)TGT>TAT	p.C395Y	LRP12_uc003ymb.2_Missense_Mutation_p.C376Y|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	395	Extracellular (Potential).|LDL-receptor class A 3.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATACCCATCACAACGCTGCTG	0.463													0	0	0	0.006214	0	8	118										T	105509596	C	T	105509596	3	4	116	1	0	0	0	0	1	0	0	0	8954	478	17	2	1407	2	LRP12	8	105509596	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	73040	105509596	40854426	155	34789										
KCNV1	27012	broad.mit.edu	37	chr8	110984590	110984593	+	Frame_Shift_Del	DEL	ACTT	ACTT	-													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcctgcgtggtctggctcccActtaggctctctaccagaag							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr8:110984590_110984593delACTT	uc003ynr.3	-	2	1227_1230	c.885_888delAAGT	c.(883-888)CTAAGTfs	p.L295fs	KCNV1_uc010mcw.2_Frame_Shift_Del_p.L295fs	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	295_296	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TCTGGCTCCCACTTAGGCTCTCTA	0.559																		21	62	---	---								-	110984593	ACTT	-	110984590	7	5	116	1	0	1	0	1	0	0	0	0	8094	156	6	0	622	0	KCNV1	8	110984590	Frame_Shift_Del	DEL	ACTT	TCGA-GV-A3JX-01A-11D-A20D-08	5474994	110984590	35379432	156	34790										
DOCK8	81704	broad.mit.edu	37	chr9	434934	434934	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgagtatctgagcatgctgGaggaccacagctacctgccc	11	13	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:434934G>C	uc003zgf.2	+	39	5150	c.5038G>C	c.(5038-5040)GAG>CAG	p.E1680Q	DOCK8_uc010mgu.2_Missense_Mutation_p.E982Q|DOCK8_uc010mgv.2_Missense_Mutation_p.E1580Q|DOCK8_uc003zgk.2_Missense_Mutation_p.E1138Q	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1680	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GAGCATGCTGGAGGACCACAG	0.488													0	0	0	0.007413	0	14	46										C	434934	G	C	434934	3	2	116	1	0	0	0	0	1	0	0	0	4693	1175	41	1	5192	1	DOCK8	9	434934	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		434934	140778497	157	34791										
DMRT1	1761	broad.mit.edu	37	chr9	841870	841870	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cgaggcattcagcaagccctCtacaccgtcggaagcccctc	9	17	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:841870C>G	uc003zgv.2	+	1	181	c.32C>G	c.(31-33)TCT>TGT	p.S11C	DMRT1_uc003zgu.1_Missense_Mutation_p.S11C	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	11					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		AGCAAGCCCTCTACACCGTCG	0.692													0	0	0	0.004482	0	7	15										G	841870	C	G	841870	3	3	116	1	0	0	0	0	1	0	0	0	4585	913	32	1	34	1	DMRT1	9	841870	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	406936	841870	140371561	158	34792										
PDCD1LG2	80380	broad.mit.edu	37	chr9	5534978	5534978	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctcaagtccaagtgagggacGaaggacagtaccaatgcata	11	9	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:5534978G>A	uc003zjg.3	+	3	562	c.289G>A	c.(289-291)GAA>AAA	p.E97K	C9orf46_uc003zjd.2_Intron|PDCD1LG2_uc011lmc.1_Missense_Mutation_p.E97K|PDCD1LG2_uc011lmd.1_Missense_Mutation_p.E97K|PDCD1LG2_uc010mhp.1_Missense_Mutation_p.E97K|PDCD1LG2_uc010mho.1_Missense_Mutation_p.E97K	NM_025239	NP_079515	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2 precursor	97	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		AGTGAGGGACGAAGGACAGTA	0.507													0	0	0	0.00632	0	26	38										A	5534978	G	A	5534978	3	1	116	1	0	0	0	0	1	0	0	0	11618	1059	37	1	295	1	PDCD1LG2	9	5534978	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	4693108	5534978	135678453	159	34793										
PTPRD	5789	broad.mit.edu	37	chr9	8499822	8499822	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagcctctacctcgactttgCgaggaggaccactaggaact	10	13	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:8499822C>T	uc003zkk.2	-	24	2858	c.2147G>A	c.(2146-2148)CGC>CAC	p.R716H	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.R716H|PTPRD_uc003zkm.2_Missense_Mutation_p.R703H|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	716	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTCGACTTTGCGAGGAGGACC	0.448										TSP Lung(15;0.13)			0	0	0	0.004878	0	30	51										T	8499822	C	T	8499822	3	4	116	1	0	0	0	0	1	0	0	0	12799	768	27	2	3747	2	PTPRD	9	8499822	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2964844	8499822	132713609	160	34794										
RUSC2	9853	broad.mit.edu	37	chr9	35555321	35555321	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cactccccgagccactggcaGaggtgccaggaaagctgggt	14	13	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35555321G>A	uc003zww.2	+	3	2534	c.2279G>A	c.(2278-2280)AGA>AAA	p.R760K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.R760K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	760						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCCACTGGCAGAGGTGCCAGG	0.667													0	0	0	0.01441	0	56	59										A	35555321	G	A	35555321	3	1	116	1	0	0	0	0	1	0	0	0	13751	942	33	1	2285	1	RUSC2	9	35555321	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	27055499	35555321	105658110	161	34795			3	163		5	5	5071	N	G	4.590524e-07
RUSC2	9853	broad.mit.edu	37	chr9	35555344	35555344	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgccaggaaagctgggtctGagccagagacctctcggcca	14	12	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35555344G>A	uc003zww.2	+	3	2557	c.2302G>A	c.(2302-2304)GAG>AAG	p.E768K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E768K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	768						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			AGCTGGGTCTGAGCCAGAGAC	0.657													0	0	0	0.01441	0	87	88										A	35555344	G	A	35555344	3	1	116	1	0	0	0	0	1	0	0	0	13751	1291	45	1	2308	1	RUSC2	9	35555344	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	23	35555344	105658087	162	34796			3	163		5	5	5071	N	G	4.590524e-07
RUSC2	9853	broad.mit.edu	37	chr9	35560363	35560363	+	Frame_Shift_Del	DEL	G	G	-													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaaggtggagaagaggaagaGgaagaagaggagacagaaga							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35560363delG	uc003zww.2	+	10	3981	c.3726delG	c.(3724-3726)GAGfs	p.E1242fs	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Frame_Shift_Del_p.E1242fs	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1242	Poly-Glu.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			aagaggaagaggaagaagagg	0.547																		8	16	---	---								-	35560363	G	-	35560363	7	5	116	1	0	1	0	1	0	0	0	0	13751	991	35	0	3760	0	RUSC2	9	35560363	Frame_Shift_Del	DEL	G	TCGA-GV-A3JX-01A-11D-A20D-08	5019	35560363	105653068	163	34797			3	163		5	5	5071	N	G	4.590524e-07
RUSC2	9853	broad.mit.edu	37	chr9	35560379	35560379	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagaggaagaagaggagacaGaagaggtggcagaggcagcc	18	5	0	7			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35560379G>A	uc003zww.2	+	10	3997	c.3742G>A	c.(3742-3744)GAA>AAA	p.E1248K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E1248K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1248	Poly-Glu.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			agaggagacagaagaggtggc	0.517													0	0	0	0.013537	0	8	18										A	35560379	G	A	35560379	3	1	116	1	0	0	0	0	1	0	0	0	13751	943	33	1	3776	1	RUSC2	9	35560379	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	16	35560379	105653052	164	34798			3	163		5	5	5071	N	G	4.590524e-07
RUSC2	9853	broad.mit.edu	37	chr9	35560391	35560391	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggagacagaagaggtggcaGaggcagccgggggctcaggg	21	7	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:35560391G>A	uc003zww.2	+	10	4009	c.3754G>A	c.(3754-3756)GAG>AAG	p.E1252K	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E1252K	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1252						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			agaggtggcagaggcagCCGG	0.502													0	0	0	0.008871	0	15	23										A	35560391	G	A	35560391	3	1	116	1	0	0	0	0	1	0	0	0	13751	943	33	1	3788	1	RUSC2	9	35560391	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	12	35560391	105653040	165	34799			3	163		5	5	5071	N	G	4.590524e-07
SLC28A3	64078	broad.mit.edu	37	chr9	86900922	86900922	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acagggctgaattcataaaaGacagcagggccaggaaggca	13	8	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:86900922G>T	uc010mpz.2	-	13	1510	c.1385C>A	c.(1384-1386)TCT>TAT	p.S462Y	SLC28A3_uc011lsy.1_Missense_Mutation_p.S393Y|SLC28A3_uc004anu.1_Missense_Mutation_p.S462Y	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	462	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						ATTCATAAAAGACAGCAGGGC	0.498													1	0	5.35356e-11	0.00278	5.63458e-11	18	31										T	86900922	G	T	86900922	3	4	116	1	0	0	0	0	1	0	0	0	14533	942	33	3	714	3	SLC28A3	9	86900922	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	51340531	86900922	54312509	166	34800										
DAPK1	1612	broad.mit.edu	37	chr9	90296407	90296407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caagctgtttggccactcggGatccgggaaaaccacccttg	11	13	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:90296407G>A	uc004apc.2	+	20	2228	c.2090G>A	c.(2089-2091)GGA>GAA	p.G697E	DAPK1_uc004apd.2_Missense_Mutation_p.G697E|DAPK1_uc011ltg.1_Missense_Mutation_p.G697E|DAPK1_uc011lth.1_Missense_Mutation_p.G434E|DAPK1_uc004apf.1_Missense_Mutation_p.G251E	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	697					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						GGCCACTCGGGATCCGGGAAA	0.552									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.01441	0	77	75										A	90296407	G	A	90296407	3	1	116	1	0	0	0	0	1	0	0	0	4235	1174	41	1	2164	1	DAPK1	9	90296407	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3395485	90296407	50917024	167	34801										
IPPK	64768	broad.mit.edu	37	chr9	95418779	95418779	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccccaaaaactccttcatgaCatttttcccaaagtccacta	2	15	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:95418779C>T	uc004asl.1	-	3	461	c.184G>A	c.(184-186)GTC>ATC	p.V62I		NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	62					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2						TCCTTCATGACATTTTTCCCA	0.433													0	0	0	0.01441	0	55	79										T	95418779	C	T	95418779	3	4	116	1	0	0	0	0	1	0	0	0	7801	478	17	2	1335	2	IPPK	9	95418779	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5122372	95418779	45794652	168	34802										
SMC2	10592	broad.mit.edu	37	chr9	106882409	106882409	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atgagctgcgggctctagaaGaggaattagcaggtcttaaa	13	6	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:106882409G>A	uc004bbv.2	+	16	2386	c.2098G>A	c.(2098-2100)GAG>AAG	p.E700K	SMC2_uc004bbu.1_Missense_Mutation_p.E700K|SMC2_uc004bbw.2_Missense_Mutation_p.E700K|SMC2_uc011lvl.1_Missense_Mutation_p.E700K|SMC2_uc004bbx.2_Missense_Mutation_p.E700K	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	700	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						GGCTCTAGAAGAGGAATTAGC	0.353													0	0	0	0.01441	0	80	95										A	106882409	G	A	106882409	3	1	116	1	0	0	0	0	1	0	0	0	14783	943	33	1	2156	1	SMC2	9	106882409	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	11463630	106882409	34331022	169	34803										
OR13C2	392376	broad.mit.edu	37	chr9	107367631	107367631	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcactgcacagccagaaaggGaaatggtctttctttctgaa	10	9	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:107367631G>A	uc011lvq.1	-	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCCAGAAAGGGAAATGGTCTT	0.517													0	0	0	0.01441	0	51	59										A	107367631	G	A	107367631	3	1	116	1	0	0	0	0	1	0	0	0	10934	1174	41	1	681	1	OR13C2	9	107367631	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	485222	107367631	33845800	170	34804										
SVEP1	79987	broad.mit.edu	37	chr9	113341490	113341490	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cgtgggcaccacggggaagtCggacagcagcttgcggacga	17	11	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:113341490C>G	uc010mtz.2	-	1	671	c.334G>C	c.(334-336)GAC>CAC	p.D112H	SVEP1_uc010mua.1_Missense_Mutation_p.D112H|SVEP1_uc004beu.2_Missense_Mutation_p.D112H|uc004bew.1_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	112	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACGGGGAAGTCGGACAGCAGC	0.642													0	0	0	0.004672	0	2	1										G	113341490	C	G	113341490	3	3	116	1	0	0	0	0	1	0	0	0	15417	884	31	1	10573	1	SVEP1	9	113341490	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5973859	113341490	27871941	171	34805										
TLR4	7099	broad.mit.edu	37	chr9	120476771	120476771	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggtggagctgtaccgccttCtcagcaggaacacttacctg	11	12	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:120476771C>G	uc004bjz.2	+	3	2656	c.2365C>G	c.(2365-2367)CTC>GTC	p.L789V	TLR4_uc004bka.2_Missense_Mutation_p.L749V|TLR4_uc004bkb.2_Missense_Mutation_p.L589V	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	789	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GTACCGCCTTCTCAGCAGGAA	0.552													0	0	0	0.01441	0	50	55										G	120476771	C	G	120476771	3	3	116	1	0	0	0	0	1	0	0	0	15950	913	32	1	2375	1	TLR4	9	120476771	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	7135281	120476771	20736660	172	34806										
PBX3	5090	broad.mit.edu	37	chr9	128677988	128677988	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcagcatcagaggagcccagGaggaggaccctcccgatccc	12	15	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:128677988G>T	uc004bqb.2	+	3	414	c.298G>T	c.(298-300)GAG>TAG	p.E100*	PBX3_uc004bqc.2_Intron|PBX3_uc004bqd.2_Intron|PBX3_uc011lzw.1_Nonsense_Mutation_p.E25*|PBX3_uc011lzx.1_Nonsense_Mutation_p.E11*|PBX3_uc004bqe.2_5'UTR	NM_006195	NP_006186	P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3 isoform 1	100					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						AGGAGCCCAGGAGGAGGACCC	0.413													1	0	0.000673444	0.008291	0.000687153	11	12										T	128677988	G	T	128677988	4	4	116	1	0	0	0	0	0	1	0	0	11494	1175	41	3	308	3	PBX3	9	128677988	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	8201217	128677988	12535443	173	34807										
ZBTB34	403341	broad.mit.edu	37	chr9	129642198	129642198	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tctctcctccatattgctctCagggacggcagcccaccgca	8	17	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:129642198C>G	uc004bqm.3	+	2	605	c.508C>G	c.(508-510)CAG>GAG	p.Q170E		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATATTGCTCTCAGGGACGGCA	0.592													0	0	0	0.01441	0	40	46										G	129642198	C	G	129642198	3	3	116	1	0	0	0	0	1	0	0	0	17534	827	29	1	510	1	ZBTB34	9	129642198	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	964210	129642198	11571233	174	34808										
ZBTB34	403341	broad.mit.edu	37	chr9	129642324	129642324	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgggagcgtttctgaatatGagattcagatagagggagac	15	4	2	5			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:129642324G>C	uc004bqm.3	+	2	731	c.634G>C	c.(634-636)GAG>CAG	p.E212Q		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCTGAATATGAGATTCAGAT	0.577													0	0	0	0.001984	0	6	45										C	129642324	G	C	129642324	3	2	116	1	0	0	0	0	1	0	0	0	17534	1291	45	1	636	1	ZBTB34	9	129642324	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	126	129642324	11571107	175	34809										
FAM129B	64855	broad.mit.edu	37	chr9	130280190	130280190	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggatggcatctgtgaacgcaGggccctctaccttggagtcc	13	12	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:130280190G>C	uc004brh.2	-	6	822	c.620C>G	c.(619-621)CCT>CGT	p.P207R	FAM129B_uc004bri.2_Missense_Mutation_p.P194R|FAM129B_uc004brj.3_Missense_Mutation_p.P207R	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	207							protein binding				0						TGTGAACGCAGGGCCCTCTAC	0.612													0	0	0	0.00278	0	21	17										C	130280190	G	C	130280190	3	2	116	1	0	0	0	0	1	0	0	0	5437	1000	35	4	1656	4	FAM129B	9	130280190	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	637866	130280190	10933241	176	34810										
GOLGA2	2801	broad.mit.edu	37	chr9	131023520	131023520	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	actcatgctacattccttctCctctctcaatgtgtgcacct	4	15	4	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131023520C>T	uc011maw.1	-	16	1283	c.1270G>A	c.(1270-1272)GAG>AAG	p.E424K	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_5'Flank|GOLGA2_uc004bul.1_Missense_Mutation_p.E325K|uc004bun.2_5'Flank	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	424	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CATTCCTTCTCCTCTCTCAAT	0.607													0	0	0	0.007413	0	16	160										T	131023520	C	T	131023520	3	4	116	1	0	0	0	0	1	0	0	0	6552	864	30	1	1782	1	GOLGA2	9	131023520	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	743330	131023520	10189911	177	34811										
SPTAN1	6709	broad.mit.edu	37	chr9	131346753	131346753	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcttccgggatgttgaggatGaggagacgtggattcgagag	17	5	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131346753G>C	uc004bvl.3	+	17	2499	c.2386G>C	c.(2386-2388)GAG>CAG	p.E796Q	SPTAN1_uc011mbg.1_Missense_Mutation_p.E796Q|SPTAN1_uc011mbh.1_Missense_Mutation_p.E808Q|SPTAN1_uc004bvm.3_Missense_Mutation_p.E796Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E796Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	796	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGTTGAGGATGAGGAGACGTG	0.562													0	0	0	0.00245	0	13	26										C	131346753	G	C	131346753	3	2	116	1	0	0	0	0	1	0	0	0	15116	1291	45	1	2448	1	SPTAN1	9	131346753	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	323233	131346753	9866678	178	34812										
SPTAN1	6709	broad.mit.edu	37	chr9	131348070	131348070	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaggccaagcttcacgagctGaaccaaaagtgggaggcact	12	10	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131348070G>A	uc004bvl.3	+	19	2717	c.2604G>A	c.(2602-2604)CTG>CTA	p.L868L	SPTAN1_uc011mbg.1_Silent_p.L868L|SPTAN1_uc011mbh.1_Silent_p.L880L|SPTAN1_uc004bvm.3_Silent_p.L868L|SPTAN1_uc004bvn.3_Silent_p.L868L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	868	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TTCACGAGCTGAACCAAAAGT	0.527													0	0	0	0.009535	0	28	61										A	131348070	G	A	131348070	2	1	116	1	0	0	0	0	0	0	0	1	15116	1277	45	1		1	SPTAN1	9	131348070	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1317	131348070	9865361	179	34813										
SPTAN1	6709	broad.mit.edu	37	chr9	131348091	131348091	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaccaaaagtgggaggcactGaaagccaaagcttcccagcg	11	11	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:131348091G>A	uc004bvl.3	+	19	2738	c.2625G>A	c.(2623-2625)CTG>CTA	p.L875L	SPTAN1_uc011mbg.1_Silent_p.L875L|SPTAN1_uc011mbh.1_Silent_p.L887L|SPTAN1_uc004bvm.3_Silent_p.L875L|SPTAN1_uc004bvn.3_Silent_p.L875L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	875	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGGAGGCACTGAAAGCCAAAG	0.537													0	0	0	0.004289	0	31	51										A	131348091	G	A	131348091	2	1	116	1	0	0	0	0	0	0	0	1	15116	1277	45	1		1	SPTAN1	9	131348091	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	21	131348091	9865340	180	34814										
BRD3	8019	broad.mit.edu	37	chr9	136917464	136917464	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caatttgtaaacatggtgttGaagtcctgcatacattcgct	8	8	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:136917464G>A	uc004cew.2	-	3	503	c.315C>T	c.(313-315)TTC>TTT	p.F105F	BRD3_uc004cex.2_Silent_p.F105F	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	105	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		ACATGGTGTTGAAGTCCTGCA	0.398			T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.000602	0	5	52										A	136917464	G	A	136917464	2	1	116	1	0	0	0	0	0	0	0	1	1503	1281	45	1		1	BRD3	9	136917464	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5569373	136917464	4295967	181	34815										
UAP1L1	91373	broad.mit.edu	37	chr9	139973451	139973451	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcaacgggggcctctactgcGcgctggaggaccacaagatc	14	13	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:139973451G>A	uc010ncb.2	+	4	726	c.694G>A	c.(694-696)GCG>ACG	p.A232T	UAP1L1_uc004cla.3_Missense_Mutation_p.A109T	NM_207309	NP_997192	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like	232							nucleotidyltransferase activity			ovary(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CCTCTACTGCGCGCTGGAGGA	0.652													0	0	0	0.01441	0	37	36										A	139973451	G	A	139973451	3	1	116	1	0	0	0	0	1	0	0	0	16823	1087	38	2	708	2	UAP1L1	9	139973451	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3055987	139973451	1239980	182	34816										
TUBB2C	10383	broad.mit.edu	37	chr9	140137804	140137804	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acggccatccaggagctgttCaagcgcatctccgagcagtt	11	13	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr9:140137804C>G	uc004cmh.1	+	4	1236	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	TUBB2C_uc004cmg.1_Missense_Mutation_p.F232L	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	378					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		AGGAGCTGTTCAAGCGCATCT	0.597													0	0	0	0.01441	0	82	171										G	140137804	C	G	140137804	3	3	116	1	0	0	0	0	1	0	0	0	16753	825	29	1	1148	1	TUBB2C	9	140137804	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	164353	140137804	1075627	183	34817										
CUBN	8029	broad.mit.edu	37	chr10	17145185	17145185	+	Frame_Shift_Del	DEL	G	G	-													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	catgaacataaccaacatccGggctcctgtagctgaagctt							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:17145185delG	uc001ioo.2	-	13	1521	c.1469delC	c.(1468-1470)CCGfs	p.P490fs		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	490	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACCAACATCCGGGCTCCTGTA	0.398																		45	73	---	---								-	17145185	G	-	17145185	7	5	116	1	0	1	0	1	0	0	0	0	4051	1116	39	0	9622	0	CUBN	10	17145185	Frame_Shift_Del	DEL	G	TCGA-GV-A3JX-01A-11D-A20D-08		17145185	118389562	184	34818										
NSUN6	221078	broad.mit.edu	37	chr10	18840786	18840786	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcgctgtaatggctgatatGatgccacttccttcacagac	8	11	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:18840786G>T	uc010qcp.1	-	9	1455	c.1037C>A	c.(1036-1038)TCA>TAA	p.S346*		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	346							methyltransferase activity|RNA binding			ovary(2)	2						TGGCTGATATGATGCCACTTC	0.423													1	0	0.00198382	0.001984	0.00201395	5	155										T	18840786	G	T	18840786	4	4	116	1	0	0	0	0	0	1	0	0	10682	1294	45	3	384	3	NSUN6	10	18840786	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1695601	18840786	116693961	185	34819										
ARMC4	55130	broad.mit.edu	37	chr10	28276464	28276464	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caacttcttctgatttgactGttgtttcactaaaaaataaa	4	7	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:28276464G>C	uc009xky.2	-	3	331	c.233C>G	c.(232-234)ACA>AGA	p.T78R	ARMC4_uc001itz.2_Missense_Mutation_p.T78R	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	78							binding			ovary(4)|skin(2)	6						TGATTTGACTGTTGTTTCACt	0.318													0	0	0	0.006214	0	8	22										C	28276464	G	C	28276464	3	2	116	1	0	0	0	0	1	0	0	0	953	1377	48	4	2973	4	ARMC4	10	28276464	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	9435678	28276464	107258283	186	34820										
VCL	7414	broad.mit.edu	37	chr10	75849105	75849105	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caaagaagatcgatgctgctCaggtagtcacagtgattttc	10	8	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:75849105C>T	uc001jwd.2	+	9	1268	c.1174C>T	c.(1174-1176)CAG>TAG	p.Q392*	VCL_uc009xrr.2_Nonsense_Mutation_p.Q141*|VCL_uc010qky.1_Nonsense_Mutation_p.Q299*|VCL_uc001jwe.2_Nonsense_Mutation_p.Q392*|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	392	N-terminal globular head.|3 X 112 AA tandem repeats.|2.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					CGATGCTGCTCAGGTAGTCAC	0.423													0	0	0	0.01441	0	35	8										T	75849105	C	T	75849105	4	4	116	1	0	0	0	0	0	1	0	0	17136	827	29	1	1208	1	VCL	10	75849105	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	47572641	75849105	59685642	187	34821										
PKD2L1	9033	broad.mit.edu	37	chr10	102056962	102056962	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtagctggaaactccaccacCagcctatagggggaggggga	15	10	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:102056962C>T	uc001kqx.1	-	6	1343	c.960G>A	c.(958-960)CTG>CTA	p.L320L	PKD2L1_uc009xwm.1_Silent_p.L273L	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	320	Helical; (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		ACTCCACCACCAGCCTATAGG	0.582													0	0	0	0.000602	0	4	52										T	102056962	C	T	102056962	2	4	116	1	0	0	0	0	0	0	0	1	11967	581	21	2		2	PKD2L1	10	102056962	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	26207857	102056962	33477785	188	34822										
PDCD11	22984	broad.mit.edu	37	chr10	105191938	105191938	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctcactctgttagccccatgGagaagattaaacagtaccag	8	11	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:105191938G>A	uc001kwy.1	+	22	3508	c.3421G>A	c.(3421-3423)GAG>AAG	p.E1141K		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1141					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TAGCCCCATGGAGAAGATTAA	0.438													0	0	0	0.00278	0	17	69										A	105191938	G	A	105191938	3	1	116	1	0	0	0	0	1	0	0	0	11617	1175	41	1	3503	1	PDCD11	10	105191938	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3134976	105191938	30342809	189	34823										
SORCS1	114815	broad.mit.edu	37	chr10	108371749	108371749	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gttgtagtcatccaggtttgGagaaaaggacaagcgaagag	14	5	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:108371749G>C	uc001kym.2	-	22	2961	c.2953C>G	c.(2953-2955)CCA>GCA	p.P985A	SORCS1_uc001kyl.2_Missense_Mutation_p.P985A|SORCS1_uc009xxs.2_Missense_Mutation_p.P985A|SORCS1_uc001kyn.1_Missense_Mutation_p.P985A|SORCS1_uc001kyo.2_Missense_Mutation_p.P985A	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	985	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCCAGGTTTGGAGAAAAGGAC	0.458													0	0	0	0.004878	0	33	7										C	108371749	G	C	108371749	3	2	116	1	0	0	0	0	1	0	0	0	14930	1174	41	1	807	1	SORCS1	10	108371749	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3179811	108371749	27162998	190	34824										
MKI67	4288	broad.mit.edu	37	chr10	129904104	129904104	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cctactttccccaaggatatCttgagtcgttgcttggagct	9	11	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr10:129904104C>G	uc001lke.2	-	13	6195	c.6000G>C	c.(5998-6000)AAG>AAC	p.K2000N	MKI67_uc001lkf.2_Missense_Mutation_p.K1640N|MKI67_uc009yav.1_Missense_Mutation_p.K1575N|MKI67_uc009yaw.1_Missense_Mutation_p.K1150N	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2000	16 X 122 AA approximate repeats.|9.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CCAAGGATATCTTGAGTCGTT	0.493													0	0	0	0.01441	0	168	41										G	129904104	C	G	129904104	3	3	116	1	0	0	0	0	1	0	0	0	9598	912	32	1	3782	1	MKI67	10	129904104	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	21532355	129904104	5630643	191	34825										
KRTAP5-4	387267	broad.mit.edu	37	chr11	1642643	1642643	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgagtccagagcctcagatCttacactggcagcacacagg	10	13	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:1642643C>G	uc009ycy.1	-	4	906	c.819G>C	c.(817-819)AAG>AAC	p.K273N		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	287						keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCTCAGATCTTACACTGGC	0.547													0	0	0	0.006214	0	9	159										G	1642643	C	G	1642643	3	3	116	1	0	0	0	0	1	0	0	0	8563	912	32	1	9	1	KRTAP5-4	11	1642643	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		1642643	133363873	192	34826										
TRPM5	29850	broad.mit.edu	37	chr11	2427906	2427906	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cgcacctgtgggcggttttcCgcagcacctccccctcgctg	11	18	0	0	rs148532424		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:2427906C>T	uc001lwm.3	-	21	3245	c.3236G>A	c.(3235-3237)CGG>CAG	p.R1079Q	TRPM5_uc010qxl.1_Missense_Mutation_p.R1079Q|TRPM5_uc009ydn.2_Missense_Mutation_p.R1081Q	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	1079	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGCGGTTTTCCGCAGCACCTC	0.617													0	0	0	0.01441	0	74	96										T	2427906	C	T	2427906	3	4	116	1	0	0	0	0	1	0	0	0	16586	652	23	2	277	2	TRPM5	11	2427906	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	785263	2427906	132578610	193	34827										
OR51F1	256892	broad.mit.edu	37	chr11	4790271	4790271	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttttgtttttacactgtcgaTgatggggttgagcacagggg	14	5	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:4790271T>C	uc010qyl.1	-	1	877	c.877A>G	c.(877-879)ATC>GTC	p.I293V		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	293						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACACTGTCGATGATGGGGTTG	0.448													0	0	0	0.01441	0	56	69										C	4790271	T	C	4790271	3	2	116	1	0	0	0	0	1	0	0	0	11096	1464	51	5	64	5	OR51F1	11	4790271	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	2362365	4790271	130216245	194	34828										
OR2D3	120775	broad.mit.edu	37	chr11	6942471	6942471	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcccatgtatttttttcttaGaaatctctcctttgcagatc	4	10	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:6942471G>C	uc010rav.1	+	1	239	c.239G>C	c.(238-240)AGA>ACA	p.R80T		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	80	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTTTTTCTTAGAAATCTCTCC	0.408													0	0	0	0.01441	0	55	58										C	6942471	G	C	6942471	3	2	116	1	0	0	0	0	1	0	0	0	10995	942	33	1	241	1	OR2D3	11	6942471	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2152200	6942471	128064045	195	34829										
MRGPRX3	117195	broad.mit.edu	37	chr11	18159013	18159013	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgttcgccgttacgcctcatCaatatccgccatcccatctc	5	17	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:18159013C>G	uc001mnu.2	+	3	625	c.264C>G	c.(262-264)ATC>ATG	p.I88M		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	88	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						TACGCCTCATCAATATCCGCC	0.547													0	0	0	0.00874	0	42	50										G	18159013	C	G	18159013	3	3	116	1	0	0	0	0	1	0	0	0	9768	816	29	1	266	1	MRGPRX3	11	18159013	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	11216542	18159013	116847503	196	34830										
ABTB2	25841	broad.mit.edu	37	chr11	34181459	34181459	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgaggctgcctacctgttaGaagctgtcaccagcaggact	11	12	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:34181459G>C	uc001mvl.1	-	13	2272	c.2042C>G	c.(2041-2043)TCT>TGT	p.S681C		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	681							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				CTACCTGTTAGAAGCTGTCAC	0.488													0	0	0	0.009535	0	27	22										C	34181459	G	C	34181459	3	2	116	1	0	0	0	0	1	0	0	0	103	942	33	1	497	1	ABTB2	11	34181459	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	16022446	34181459	100825057	197	34831										
SERPING1	710	broad.mit.edu	37	chr11	57367761	57367761	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agatttctccctgaagctctAccacgccttctcagcaatga	6	14	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:57367761A>G	uc001nkp.1	+	3	652	c.461A>G	c.(460-462)TAC>TGC	p.Y154C	SERPING1_uc001nkq.1_Missense_Mutation_p.Y154C|SERPING1_uc010rju.1_Missense_Mutation_p.Y102C|SERPING1_uc010rjv.1_Missense_Mutation_p.Y159C|SERPING1_uc001nkr.1_Missense_Mutation_p.Y154C|SERPING1_uc009ymi.1_Missense_Mutation_p.Y154C|SERPING1_uc009ymj.1_Missense_Mutation_p.Y154C|SERPING1_uc001nks.1_Intron	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	154					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						CTGAAGCTCTACCACGCCTTC	0.542									Hereditary_Angioedema				0	0	0	0.00245	0	10	169										G	57367761	A	G	57367761	3	3	116	1	0	0	0	0	1	0	0	0	14116	391	14	5	467	5	SERPING1	11	57367761	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	23186302	57367761	77638755	198	34832										
DAGLA	747	broad.mit.edu	37	chr11	61507077	61507077	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctctcagccagcactccactCtacccgcccggccgcatcat	6	21	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:61507077C>T	uc001nsa.2	+	17	1908	c.1797C>T	c.(1795-1797)CTC>CTT	p.L599L		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	599	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GCACTCCACTCTACCCGCCCG	0.657													0	0	0	0.01441	0	48	63										T	61507077	C	T	61507077	2	4	116	1	0	0	0	0	0	0	0	1	4226	900	32	1		1	DAGLA	11	61507077	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4139316	61507077	73499439	199	34833										
KRTAP5-7	440050	broad.mit.edu	37	chr11	71238815	71238815	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gctcccagtctagctgctgtGtccccgtgtgctgccagtgt	12	14	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:71238815G>T	uc001oqq.1	+	1	503	c.469G>T	c.(469-471)GTC>TTC	p.V157F		NM_001012503	NP_001012521	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	157	7 X 4 AA repeats of C-C-X-P.|7.					keratin filament					0						TAGCTGCTGTGTCCCCGTGTG	0.323													1	0	2.45186e-53	0.01441	2.679e-53	136	202										T	71238815	G	T	71238815	3	4	116	1	0	0	0	0	1	0	0	0	8566	1377	48	4	471	4	KRTAP5-7	11	71238815	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	9731738	71238815	63767701	200	34834										
TMEM126A	84233	broad.mit.edu	37	chr11	85366703	85366704	+	Frame_Shift_Ins	INS	-	-	TA													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tggtcttgttattggtggtcINStataccctgttttcttggct							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:85366703_85366704insTA	uc001par.2	+	4	442_443	c.346_347insTA	c.(346-348)CTAfs	p.L116fs		NM_032273	NP_115649	Q9H061	T126A_HUMAN	transmembrane protein 126A	116	Helical; (Potential).					integral to membrane|mitochondrion				ovary(2)	2		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TATTGGTGGTCTATACCCTGTT	0.366																		84	231	---	---								TA	85366704	-	TA	85366703	7	5	116	1	0	1	1	0	0	0	0	0	16035	912	32	0	356	0	TMEM126A	11	85366703	Frame_Shift_Ins	INS	-	TCGA-GV-A3JX-01A-11D-A20D-08	14127888	85366703	49639813	201	34835										
FAT3	120114	broad.mit.edu	37	chr11	92087838	92087838	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtactgaaatcattcaagtgGaagccagagacaaagactta	9	7	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:92087838G>A	uc001pdj.3	+	1	2577	c.2560G>A	c.(2560-2562)GAA>AAA	p.E854K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	854	Cadherin 8.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CATTCAAGTGGAAGCCAGAGA	0.393										TCGA Ovarian(4;0.039)			0	0	0	0.004656	0	22	27										A	92087838	G	A	92087838	3	1	116	1	0	0	0	0	1	0	0	0	5691	1175	41	1	2562	1	FAT3	11	92087838	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	6721135	92087838	42918678	202	34836										
KIAA1377	57562	broad.mit.edu	37	chr11	101868342	101868342	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atttccaggagaagagagaaGatagaaccagcagctgcaga	12	7	0	6			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:101868342G>C	uc001pgm.2	+	11	3592	c.3322G>C	c.(3322-3324)GAT>CAT	p.D1108H	KIAA1377_uc001pgn.2_Missense_Mutation_p.D1064H|KIAA1377_uc010run.1_Missense_Mutation_p.D909H	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	1108							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAAGAGAGAAGATAGAACCAG	0.428													0	0	0	0.001168	0	5	88										C	101868342	G	C	101868342	3	2	116	1	0	0	0	0	1	0	0	0	8227	942	33	1	3364	1	KIAA1377	11	101868342	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	9780504	101868342	33138174	203	34837										
DLAT	1737	broad.mit.edu	37	chr11	111896985	111896985	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tagcccgttgggaaaaaaaaGagggggacaaaatcaatgaa	12	5	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:111896985G>A	uc001pmo.2	+	2	1002	c.343G>A	c.(343-345)GAG>AAG	p.E115K	DLAT_uc009yyk.1_Missense_Mutation_p.E115K|DLAT_uc010rwr.1_Missense_Mutation_p.E115K	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	115	Lipoyl-binding 1.				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	GGAAAAAAAAGAGGGGGACAA	0.303													0	0	0	0.006214	0	5	19										A	111896985	G	A	111896985	3	1	116	1	0	0	0	0	1	0	0	0	4549	943	33	1	349	1	DLAT	11	111896985	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	10028643	111896985	23109531	204	34838										
USP28	57646	broad.mit.edu	37	chr11	113672370	113672370	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggagtgatcatcatttgtttCaaaaagagaagctgctttgg	11	5	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:113672370C>T	uc001poh.2	-	24	2926	c.2893G>A	c.(2893-2895)GAA>AAA	p.E965K	USP28_uc001pog.2_Missense_Mutation_p.E641K|USP28_uc010rwy.1_Missense_Mutation_p.E808K|USP28_uc001poi.2_Missense_Mutation_p.E288K	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	965					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCATTTGTTTCAAAAAGAGAA	0.363													0	0	0	0.005443	0	20	34										T	113672370	C	T	113672370	3	4	116	1	0	0	0	0	1	0	0	0	17055	835	29	1	348	1	USP28	11	113672370	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1775385	113672370	21334146	205	34839										
PHLDB1	23187	broad.mit.edu	37	chr11	118485345	118485345	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gacaaaccccacctggtgagCctgggcagtgggcgactcag	14	13	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:118485345C>T	uc001ptr.1	+	4	485	c.132C>T	c.(130-132)AGC>AGT	p.S44S	PHLDB1_uc010ryh.1_Silent_p.S44S|PHLDB1_uc001pts.2_Silent_p.S44S|PHLDB1_uc001ptt.2_Silent_p.S44S|PHLDB1_uc001ptu.1_RNA	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	44											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACCTGGTGAGCCTGGGCAGTG	0.572													0	0	0	0.00499	0	17	23										T	118485345	C	T	118485345	2	4	116	1	0	0	0	0	0	0	0	1	11851	738	26	2		2	PHLDB1	11	118485345	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4812975	118485345	16521171	206	34840										
SORL1	6653	broad.mit.edu	37	chr11	121485651	121485651	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgacttgggggatagccctCtggcatttgagcatgttatg	13	8	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:121485651C>G	uc001pxx.2	+	41	5571	c.5491C>G	c.(5491-5493)CTG>GTG	p.L1831V	SORL1_uc010rzp.1_Missense_Mutation_p.L677V|SORL1_uc010rzq.1_Missense_Mutation_p.L446V	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1831	Extracellular (Potential).|Fibronectin type-III 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GGATAGCCCTCTGGCATTTGA	0.527													0	0	0	0.003163	0	14	180										G	121485651	C	G	121485651	3	3	116	1	0	0	0	0	1	0	0	0	14934	912	32	1	5653	1	SORL1	11	121485651	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3000306	121485651	13520865	207	34841										
UBASH3B	84959	broad.mit.edu	37	chr11	122672000	122672000	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgcatggatacctccatcaGagttagctgcagccaacctg	9	13	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:122672000G>C	uc001pyi.3	+	11	1915	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	519	Protein tyrosine phosphatase (By similarity).					cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		ACCTCCATCAGAGTTAGCTGC	0.488													0	0	0	0.008871	0	16	206										C	122672000	G	C	122672000	3	2	116	1	0	0	0	0	1	0	0	0	16837	943	33	1	1597	1	UBASH3B	11	122672000	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1186349	122672000	12334516	208	34842										
OR8B2	26595	broad.mit.edu	37	chr11	124253209	124253209	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	taatccagcaagaataaattCagtcactaaggagttgtttc	7	7	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:124253209C>T	uc010sai.1	-	1	31	c.31G>A	c.(31-33)GAA>AAA	p.E11K	OR8B2_uc001qab.3_RNA	NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGAATAAATTCAGTCACTAAG	0.373													0	0	0	0.010818	0	12	138										T	124253209	C	T	124253209	3	4	116	1	0	0	0	0	1	0	0	0	11227	835	29	1	913	1	OR8B2	11	124253209	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1581209	124253209	10753307	209	34843										
PRDM10	56980	broad.mit.edu	37	chr11	129785719	129785719	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgctcctgggtggttcttcaGaatgtgggctttgcgcttgc	14	9	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:129785719G>C	uc001qfm.2	-	17	2606	c.2374C>G	c.(2374-2376)CTG>GTG	p.L792V	PRDM10_uc001qfj.2_Missense_Mutation_p.L706V|PRDM10_uc001qfk.2_Missense_Mutation_p.L702V|PRDM10_uc001qfl.2_Missense_Mutation_p.L706V|PRDM10_uc010sbx.1_Missense_Mutation_p.L702V|PRDM10_uc001qfn.2_Missense_Mutation_p.L788V|PRDM10_uc009zcs.1_5'UTR	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	792	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TGGTTCTTCAGAATGTGGGCT	0.532													0	0	0	0.001984	0	6	123										C	129785719	G	C	129785719	3	2	116	1	0	0	0	0	1	0	0	0	12451	933	33	1	1132	1	PRDM10	11	129785719	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5532510	129785719	5220797	210	34844										
APLP2	334	broad.mit.edu	37	chr11	130003611	130003611	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttatgtagcccaagaaattCaagaggaaattggtgggtac	11	6	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr11:130003611C>G	uc010sby.1	+	12	1829	c.1672C>G	c.(1672-1674)CAA>GAA	p.Q558E	APLP2_uc001qfp.2_Missense_Mutation_p.Q558E|APLP2_uc001qfq.2_Missense_Mutation_p.Q502E|APLP2_uc010sbz.1_Missense_Mutation_p.Q346E|APLP2_uc001qfr.2_Missense_Mutation_p.Q324E|APLP2_uc001qfs.2_Missense_Mutation_p.Q329E|APLP2_uc001qfv.2_Missense_Mutation_p.Q449E	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	558	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		CCAAGAAATTCAAGAGGAAAT	0.478													0	0	0	0.009096	0	4	78										G	130003611	C	G	130003611	3	3	116	1	0	0	0	0	1	0	0	0	779	827	29	1	1718	1	APLP2	11	130003611	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	217892	130003611	5002905	211	34845										
C12orf4	57102	broad.mit.edu	37	chr12	4639192	4639192	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcatcccagctgggttcttCaggccttgcatgctctaacg	9	13	4	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:4639192C>G	uc001qms.2	-	4	437	c.349G>C	c.(349-351)GAA>CAA	p.E117Q	C12orf4_uc001qmt.2_Missense_Mutation_p.E117Q	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	117											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CTGGGTTCTTCAGGCCTTGCA	0.343													0	0	0	0.001168	0	6	96										G	4639192	C	G	4639192	3	3	116	1	0	0	0	0	1	0	0	0	1685	835	29	1	1353	1	C12orf4	12	4639192	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		4639192	129212703	212	34846										
KLRC4	8302	broad.mit.edu	37	chr12	10562024	10562024	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttgtcattcccttgatgatCcgaagaagcattttgaaggt	9	8	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:10562024C>G	uc001qye.2	-	1	333	c.151G>C	c.(151-153)GAT>CAT	p.D51H	KLRK1_uc001qyc.2_5'Flank|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_Intron	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	51	Cytoplasmic (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						CCTTGATGATCCGAAGAAGCA	0.353													0	0	0	0.003163	0	10	140										G	10562024	C	G	10562024	3	3	116	1	0	0	0	0	1	0	0	0	8418	855	30	1	341	1	KLRC4	12	10562024	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5922832	10562024	123289871	213	34847										
TAS2R9	50835	broad.mit.edu	37	chr12	10962188	10962188	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaatttccaagtaatgttttCttcatgactgactttgaaaa	6	6	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:10962188C>G	uc001qyx.2	-	1	580	c.487G>C	c.(487-489)GAA>CAA	p.E163Q	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	163	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GTAATGTTTTCTTCATGACTG	0.378													0	0	0	0.00308	0	8	61										G	10962188	C	G	10962188	3	3	116	1	0	0	0	0	1	0	0	0	15585	922	32	1	455	1	TAS2R9	12	10962188	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	400164	10962188	122889707	214	34848										
MANSC1	54682	broad.mit.edu	37	chr12	12491411	12491411	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tttcaatggacaggcttcctCgttgggacagaaaaataggt	11	7	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:12491411C>T	uc001rai.1	-	3	565	c.307G>A	c.(307-309)GAG>AAG	p.E103K	MANSC1_uc010shm.1_Missense_Mutation_p.E37K|MANSC1_uc001raj.1_Missense_Mutation_p.E69K|MANSC1_uc009zht.1_Missense_Mutation_p.E22K	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	103	MANSC.|Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CAGGCTTCCTCGTTGGGACAG	0.383													0	0	0	0.001984	0	5	159										T	12491411	C	T	12491411	3	4	116	1	0	0	0	0	1	0	0	0	9224	893	31	1	996	1	MANSC1	12	12491411	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1529223	12491411	121360484	215	34849										
PIK3C2G	5288	broad.mit.edu	37	chr12	18552648	18552648	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atcgcttctactgcaataatGaaaactgctcccttccttta	4	12	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:18552648G>A	uc001rdt.2	+	15	2175	c.2059G>A	c.(2059-2061)GAA>AAA	p.E687K	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.E728K|PIK3C2G_uc010sic.1_Missense_Mutation_p.E506K	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	687					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CTGCAATAATGAAAACTGCTC	0.388													0	0	0	0.005443	0	24	48										A	18552648	G	A	18552648	3	1	116	1	0	0	0	0	1	0	0	0	11911	1291	45	1	2113	1	PIK3C2G	12	18552648	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	6061237	18552648	115299247	216	34850										
ABCC9	10060	broad.mit.edu	37	chr12	22063765	22063765	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acagtctttacataccagcaGagctccacggaggttaatgc	9	11	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:22063765G>C	uc001rfi.1	-	7	1179	c.1159C>G	c.(1159-1161)CTG>GTG	p.L387V	ABCC9_uc001rfh.2_Missense_Mutation_p.L387V|ABCC9_uc001rfj.1_Missense_Mutation_p.L387V	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	387	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CATACCAGCAGAGCTCCACGG	0.393													0	0	0	0.008871	0	7	105										C	22063765	G	C	22063765	3	2	116	1	0	0	0	0	1	0	0	0	59	933	33	1	3760	1	ABCC9	12	22063765	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3511117	22063765	111788130	217	34851										
FMNL3	91010	broad.mit.edu	37	chr12	50044977	50044977	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gatcttctcatcatcaagttCgctgaagacagtgccactga	8	11	4	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:50044977C>T	uc001ruv.1	-	16	2005	c.1771G>A	c.(1771-1773)GAA>AAA	p.E591K	FMNL3_uc001ruw.1_Missense_Mutation_p.E540K|FMNL3_uc001rut.1_Missense_Mutation_p.E157K|FMNL3_uc001ruu.1_Missense_Mutation_p.E441K	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	591	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						TCATCAAGTTCGCTGAAGACA	0.512													0	0	0	0.008291	0	10	141										T	50044977	C	T	50044977	3	4	116	1	0	0	0	0	1	0	0	0	5953	893	31	1	1356	1	FMNL3	12	50044977	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	27981212	50044977	83806918	218	34852										
LIMA1	51474	broad.mit.edu	37	chr12	50642443	50642443	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atatttccacaatagccgatGacttgttcttgttgacaaga	7	8	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:50642443G>A	uc001rwj.3	-	2	266	c.92C>T	c.(91-93)TCA>TTA	p.S31L	LIMA1_uc001rwk.3_Missense_Mutation_p.S31L|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	31					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						AATAGCCGATGACTTGTTCTT	0.438													0	0	0	0.010771	0	41	50										A	50642443	G	A	50642443	3	1	116	1	0	0	0	0	1	0	0	0	8796	1294	45	1	2230	1	LIMA1	12	50642443	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	597466	50642443	83209452	219	34853										
KRT79	338785	broad.mit.edu	37	chr12	53227849	53227849	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agagatactcttgtggccccCcaagttatagaggcttcggc	11	11	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:53227849C>T	uc001sbb.2	-	1	229	c.196G>A	c.(196-198)GGG>AGG	p.G66R		NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	66	Head.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						TTGTGGCCCCCCAAGTTATAG	0.642													0	0	0	0.007291	0	28	31										T	53227849	C	T	53227849	3	4	116	1	0	0	0	0	1	0	0	0	8492	623	22	2	1447	2	KRT79	12	53227849	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2585406	53227849	80624046	220	34854										
ESPL1	9700	broad.mit.edu	37	chr12	53676185	53676185	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agcctcccgtcaaacaacctCtcacactccctgtgggagca	7	17	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:53676185C>G	uc001sck.2	+	14	2848	c.2757C>G	c.(2755-2757)CTC>CTG	p.L919L	ESPL1_uc001scj.2_Silent_p.L594L|ESPL1_uc010soe.1_Silent_p.L130L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	919					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CAAACAACCTCTCACACTCCC	0.572													0	0	0	0.001168	0	5	63										G	53676185	C	G	53676185	2	3	116	1	0	0	0	0	0	0	0	1	5253	900	32	1		1	ESPL1	12	53676185	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	448336	53676185	80175710	221	34855										
TIMELESS	8914	broad.mit.edu	37	chr12	56825382	56825382	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccctactcccgccagctgctCggggttctagattggaacaa	10	14	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:56825382C>T	uc001slf.2	-	8	862	c.694G>A	c.(694-696)GAG>AAG	p.E232K	TIMELESS_uc001slg.2_Missense_Mutation_p.E231K	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	232					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GCCAGCTGCTCGGGGTTCTAG	0.517													0	0	0	0.000602	0	4	60										T	56825382	C	T	56825382	3	4	116	1	0	0	0	0	1	0	0	0	15901	893	31	1	3020	1	TIMELESS	12	56825382	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3149197	56825382	77026513	222	34856										
BAZ2A	11176	broad.mit.edu	37	chr12	56999009	56999010	+	Frame_Shift_Ins	INS	-	-	CA													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttggcaggatcaaagcccagINScaccttgccaaagctatgca							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:56999009_56999010insCA	uc001slq.1	-	14	2795_2796	c.2601_2602insTG	c.(2599-2604)GTGCTGfs	p.V867fs	BAZ2A_uc001slp.1_Frame_Shift_Ins_p.V865fs|BAZ2A_uc009zov.1_5'Flank|BAZ2A_uc009zow.1_Frame_Shift_Ins_p.V835fs	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	867_868	DDT.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TCAAAGCCCAGCACCTTGCCAA	0.574																		25	33	---	---								CA	56999010	-	CA	56999009	7	5	116	1	0	1	1	0	0	0	0	0	1331	962	34	0	3179	0	BAZ2A	12	56999009	Frame_Shift_Ins	INS	-	TCGA-GV-A3JX-01A-11D-A20D-08	173627	56999009	76852886	223	34857										
CDK4	1019	broad.mit.edu	37	chr12	58144834	58144834	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgaacgatgcaattggcatGaaggaaatctaggcctctta	11	7	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:58144834G>C	uc001spv.2	-	4	621	c.394C>G	c.(394-396)CAT>GAT	p.H132D	CDK4_uc010ssb.1_Missense_Mutation_p.H12D|CDK4_uc001spw.2_Intron|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	132	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CAATTGGCATGAAGGAAATCT	0.488			Mis			melanoma 			Hereditary_Melanoma				0	0	0	0.001168	0	6	75										C	58144834	G	C	58144834	3	2	116	1	0	0	0	0	1	0	0	0	3141	1290	45	1	537	1	CDK4	12	58144834	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1145825	58144834	75707061	224	34858										
CDK4	1019	broad.mit.edu	37	chr12	58144855	58144855	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaggaaatctaggcctcttaGaaactggcgcatcagatcct	9	10	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:58144855G>C	uc001spv.2	-	4	600	c.373C>G	c.(373-375)CTA>GTA	p.L125V	CDK4_uc010ssb.1_Missense_Mutation_p.L5V|CDK4_uc001spw.2_Intron|uc010ssc.1_5'Flank	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	125	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			AGGCCTCTTAGAAACTGGCGC	0.483			Mis			melanoma 			Hereditary_Melanoma				0	0	0	0.000602	0	4	68										C	58144855	G	C	58144855	3	2	116	1	0	0	0	0	1	0	0	0	3141	933	33	1	558	1	CDK4	12	58144855	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	21	58144855	75707040	225	34859										
SLC6A15	55117	broad.mit.edu	37	chr12	85266414	85266414	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcttcaattttacaggaattGagatgaagagcaggaaactc	9	6	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:85266414G>C	uc001szv.2	-	8	1762	c.1269C>G	c.(1267-1269)CTC>CTG	p.L423L	SLC6A15_uc010sul.1_Silent_p.L316L|SLC6A15_uc001szw.1_Silent_p.L131L	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	423	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						TACAGGAATTGAGATGAAGAG	0.318													0	0	0	0.012213	0	29	48										C	85266414	G	C	85266414	2	2	116	1	0	0	0	0	0	0	0	1	14678	1277	45	1		1	SLC6A15	12	85266414	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	27121559	85266414	48585481	226	34860										
PLXNC1	10154	broad.mit.edu	37	chr12	94543416	94543416	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acgcaggagctggggcgcctCaagctgtgcgagggcgcggg	20	11	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:94543416C>G	uc001tdc.2	+	1	918	c.669C>G	c.(667-669)CTC>CTG	p.L223L		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	223	Extracellular (Potential).|Sema.				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						TGGGGCGCCTCAAGCTGTGCG	0.687													0	0	0	0.004672	0	3	3										G	94543416	C	G	94543416	2	3	116	1	0	0	0	0	0	0	0	1	12126	813	29	1		1	PLXNC1	12	94543416	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	9277002	94543416	39308479	227	34861										
SYCP3	50511	broad.mit.edu	37	chr12	102122982	102122982	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atcatgattcttctccaactCttccatactctaaaaacaca	1	13	5	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:102122982C>T	uc001tiq.2	-	8	694	c.562G>A	c.(562-564)GAG>AAG	p.E188K	CHPT1_uc001tip.1_3'UTR|SYCP3_uc001tir.2_Missense_Mutation_p.E188K|SYCP3_uc001tis.2_Missense_Mutation_p.E188K	NM_153694	NP_710161	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	188	Potential.|Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding				0						TTCTCCAACTCTTCCATACTC	0.289													0	0	0	0.007291	0	25	37										T	102122982	C	T	102122982	3	4	116	1	0	0	0	0	1	0	0	0	15431	922	32	1	156	1	SYCP3	12	102122982	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	7579566	102122982	31728913	228	34862										
HCFC2	29915	broad.mit.edu	37	chr12	104487163	104487163	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aatctgttatatttcttgtaGatcaatgatacaataaacag	5	5	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:104487163G>A	uc001tkj.3	+	10	1388	c.1285_splice	c.e10-1	p.I429_splice	HCFC2_uc009zul.2_Splice_Site	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2						regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						ATTTCTTGTAGATCAATGATA	0.279													0	0	0	0.001984	0	7	49										A	104487163	G	A	104487163	5	1	116	1	0	0	0	0	0	0	1	0	6993	956	33	1	1322	1	HCFC2	12	104487163	Splice_Site	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2364181	104487163	29364732	229	34863										
MMAB	326625	broad.mit.edu	37	chr12	110002929	110002929	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gatggtgttactcactttctGaagctcttcggcaaatgtat	9	8	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:110002929G>A	uc001tou.2	-	4	416	c.343C>T	c.(343-345)CAG>TAG	p.Q115*	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Nonsense_Mutation_p.Q24*|MMAB_uc001tox.2_Nonsense_Mutation_p.Q63*	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	115					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CTCACTTTCTGAAGCTCTTCG	0.408													0	0	0	0.003954	0	19	226										A	110002929	G	A	110002929	4	1	116	1	0	0	0	0	0	1	0	0	9640	1299	45	1	433	1	MMAB	12	110002929	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5515766	110002929	23848966	230	34864										
NAA25	80018	broad.mit.edu	37	chr12	112512548	112512548	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagaatcgaaataagtcagaTagaactgccagtcatctgag	9	8	3	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:112512548T>C	uc001ttm.2	-	9	817	c.797A>G	c.(796-798)TAT>TGT	p.Y266C	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.Y238C|NAA25_uc009zwa.1_Missense_Mutation_p.Y266C	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	266						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ATAAGTCAGATAGAACTGCCA	0.398													0	0	0	0.01441	0	72	106										C	112512548	T	C	112512548	3	2	116	1	0	0	0	0	1	0	0	0	10121	1406	49	5	2185	5	NAA25	12	112512548	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	2509619	112512548	21339347	231	34865										
OASL	8638	broad.mit.edu	37	chr12	121465572	121465572	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atagatggttagaagttcaaGagcatagagagggggcagat	15	3	1	5			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:121465572G>C	uc001tzj.1	-	4	712	c.706C>G	c.(706-708)CTT>GTT	p.L236V	OASL_uc001tzk.1_Intron	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	236					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAAGTTCAAGAGCATAGAGA	0.473													0	0	0	0.009096	0	3	78										C	121465572	G	C	121465572	3	2	116	1	0	0	0	0	1	0	0	0	10802	942	33	1	850	1	OASL	12	121465572	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	8953024	121465572	12386323	232	34866										
GPR81	27198	broad.mit.edu	37	chr12	123214255	123214255	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccttcttcatccgagcctgtCtggccagctgctgcctccgc	9	18	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:123214255C>G	uc001ucz.2	-	1	875	c.632G>C	c.(631-633)AGA>ACA	p.R211T	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	211	Cytoplasmic (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CCGAGCCTGTCTGGCCAGCTG	0.527													0	0	0	0.012213	0	28	38										G	123214255	C	G	123214255	3	3	116	1	0	0	0	0	1	0	0	0	6711	913	32	1	412	1	GPR81	12	123214255	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1748683	123214255	10637640	233	34867										
GPR81	27198	broad.mit.edu	37	chr12	123214498	123214498	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agacgatgccagccgccaccCgggtggagatagtgttcacc	13	13	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr12:123214498C>T	uc001ucz.2	-	1	632	c.389G>A	c.(388-390)CGG>CAG	p.R130Q	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	130	Cytoplasmic (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		AGCCGCCACCCGGGTGGAGAT	0.602													0	0	0	0.01441	0	43	54										T	123214498	C	T	123214498	3	4	116	1	0	0	0	0	1	0	0	0	6711	652	23	2	655	2	GPR81	12	123214498	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	243	123214498	10637397	234	34868										
FLT3	2322	broad.mit.edu	37	chr13	28601286	28601286	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attgtgttccttgaaaatctCtgtccaagtcctgtgaaatt	7	8	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:28601286C>G	uc001urw.2	-	17	2228	c.2146G>C	c.(2146-2148)GAG>CAG	p.E716Q	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.E716Q	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	716	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TTGAAAATCTCTGTCCAAGTC	0.358			Mis|O		AML|ALL								0	0	0	0.014323	0	18	244										G	28601286	C	G	28601286	3	3	116	1	0	0	0	0	1	0	0	0	5942	922	32	1	867	1	FLT3	13	28601286	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		28601286	86568592	235	34869										
FRY	10129	broad.mit.edu	37	chr13	32757127	32757127	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tccacagagaattggtagaaGaacttcatccattaatgaaa	7	7	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:32757127G>C	uc001utx.2	+	24	3506	c.3010G>C	c.(3010-3012)GAA>CAA	p.E1004Q	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1004					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ATTGGTAGAAGAACTTCATCC	0.313													0	0	0	0.001984	0	7	78										C	32757127	G	C	32757127	3	2	116	1	0	0	0	0	1	0	0	0	6063	943	33	1	3104	1	FRY	13	32757127	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	4155841	32757127	82412751	236	34870										
ITM2B	9445	broad.mit.edu	37	chr13	48832951	48832951	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggctggaacctatttgcctCagtcctatctgattcatgag	9	10	3	2	rs11556901		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:48832951C>G	uc001vbz.3	+	5	806	c.583C>G	c.(583-585)CAG>GAG	p.Q195E		NM_021999	NP_068839	Q9Y287	ITM2B_HUMAN	integral membrane protein 2B	195	BRICHOS.|Lumenal (Potential).				nervous system development	Golgi membrane|integral to membrane|nucleus|plasma membrane	beta-amyloid binding				0		all_cancers(8;2.2e-31)|all_epithelial(8;6.77e-15)|all_lung(13;9.67e-07)|all_hematologic(8;9.72e-06)|Lung NSC(96;8.3e-05)|Breast(56;0.000141)|Acute lymphoblastic leukemia(8;0.00045)|Prostate(109;0.000669)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;1.97e-06)		CTATTTGCCTCAGTCCTATCT	0.373													0	0	0	0.001984	0	5	61										G	48832951	C	G	48832951	3	3	116	1	0	0	0	0	1	0	0	0	7913	827	29	1	601	1	ITM2B	13	48832951	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16075824	48832951	66336927	237	34871										
RB1	5925	broad.mit.edu	37	chr13	48934194	48934194	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atgatctggtgatttcatttCagttaatgctatgtgtcctt	8	6	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:48934194C>T	uc001vcb.2	+	7	815	c.649C>T	c.(649-651)CAG>TAG	p.Q217*	RB1_uc010acs.1_RNA|RB1_uc010act.1_5'UTR	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	217					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.Q217*(2)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GATTTCATTTCAGTTAATGCT	0.308		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.01441	0	67	17										T	48934194	C	T	48934194	4	4	116	1	0	0	0	0	0	1	0	0	13098	827	29	1	675	1	RB1	13	48934194	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	101243	48934194	66235684	238	34872										
CKAP2	26586	broad.mit.edu	37	chr13	53039469	53039469	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tactggtcacactgaatgacCtgattaaaaatattccagat	6	8	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:53039469C>T	uc001vgv.2	+	6	1545	c.1348C>T	c.(1348-1350)CTG>TTG	p.L450L	CKAP2_uc001vgt.2_Silent_p.L449L|CKAP2_uc001vgu.2_Silent_p.L449L|CKAP2_uc010tha.1_Silent_p.L401L	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	450					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		ACTGAATGACCTGATTAAAAA	0.303													0	0	0	0.001984	0	5	173										T	53039469	C	T	53039469	2	4	116	1	0	0	0	0	0	0	0	1	3442	680	24	2		2	CKAP2	13	53039469	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4105275	53039469	62130409	239	34873										
PCDH8	5100	broad.mit.edu	37	chr13	53420766	53420766	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggactggcgcatggtcgttCtggtccagcacgcgcacttg	14	12	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:53420766C>G	uc001vhi.2	-	1	2009	c.1806G>C	c.(1804-1806)CAG>CAC	p.Q602H	PCDH8_uc001vhj.2_Missense_Mutation_p.Q602H	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	602	Extracellular (Potential).|Cadherin 5.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CATGGTCGTTCTGGTCCAGCA	0.662													0	0	0	0.00308	0	5	10										G	53420766	C	G	53420766	3	3	116	1	0	0	0	0	1	0	0	0	11517	912	32	1	1418	1	PCDH8	13	53420766	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	381297	53420766	61749112	240	34874										
DZIP1	22873	broad.mit.edu	37	chr13	96246297	96246297	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttactcttcaaagctttcctTaaatgcattttgttgttatt	4	7	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:96246297T>C	uc001vmk.2	-	16	2433	c.1581A>G	c.(1579-1581)TTA>TTG	p.L527L	DZIP1_uc001vmj.2_Silent_p.L3L|DZIP1_uc001vml.2_Silent_p.L508L	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	527					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AAGCTTTCCTTAAATGCATTT	0.333													0	0	0	0.012213	0	34	66										C	96246297	T	C	96246297	2	2	116	1	0	0	0	0	0	0	0	1	4863	1751	61	5		5	DZIP1	13	96246297	Silent	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	42825531	96246297	18923581	241	34875										
GAS6	2621	broad.mit.edu	37	chr13	114523972	114523972	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cggtagaacgcggtgactggCgctgaagtcaccggcacatc	14	12	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr13:114523972C>T	uc001vud.2	-	15	2055	c.1902G>A	c.(1900-1902)GCG>GCA	p.A634A	GAS6_uc001vug.2_Silent_p.A335A|GAS6_uc001vuf.2_Silent_p.A361A	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	677	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				CGGTGACTGGCGCTGAAGTCA	0.672													0	0	0	0.001984	0	4	67										T	114523972	C	T	114523972	2	4	116	1	0	0	0	0	0	0	0	1	6249	755	27	2		2	GAS6	13	114523972	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	18277675	114523972	645906	242	34876										
SALL2	6297	broad.mit.edu	37	chr14	21993420	21993420	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tggaggtaatggggttgctcCcagcttgggactggccaaga	16	8	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:21993420C>T	uc001wbe.2	-	2	724	c.442G>A	c.(442-444)GGA>AGA	p.G148R	SALL2_uc010tly.1_Missense_Mutation_p.G146R|SALL2_uc010tlz.1_Intron|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Intron|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	148							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGGGTTGCTCCCAGCTTGGGA	0.652													0	0	0	0.01441	0	46	73										T	21993420	C	T	21993420	3	4	116	1	0	0	0	0	1	0	0	0	13811	632	22	2	2585	2	SALL2	14	21993420	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		21993420	85356120	243	34877										
HECTD1	25831	broad.mit.edu	37	chr14	31626439	31626439	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attgtgaccaacatcagaatCacaaacttcttttaacagtg	5	9	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:31626439C>T	uc001wrc.1	-	11	2182	c.1693G>A	c.(1693-1695)GAT>AAT	p.D565N	HECTD1_uc001wrd.1_Missense_Mutation_p.D80N	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	565					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACATCAGAATCACAAACTTCT	0.338													0	0	0	0.01441	0	74	87										T	31626439	C	T	31626439	3	4	116	1	0	0	0	0	1	0	0	0	7039	826	29	1	6271	1	HECTD1	14	31626439	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	9633019	31626439	75723101	244	34878										
KTN1	3895	broad.mit.edu	37	chr14	56142555	56142555	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gttcctttatttttacagttGaaggcacagttaaatgaaac	7	6	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:56142555G>A	uc001xcb.2	+	42	4076	c.3774G>A	c.(3772-3774)TTG>TTA	p.L1258L	KTN1_uc001xce.2_Silent_p.L1201L|KTN1_uc001xcc.2_Silent_p.L1258L|KTN1_uc001xcd.2_Silent_p.L1207L|KTN1_uc010trb.1_Silent_p.L1230L|KTN1_uc001xcf.1_Silent_p.L1207L|KTN1_uc010aoq.2_Silent_p.L496L|KTN1_uc010trc.1_Silent_p.L235L|KTN1_uc001xcg.2_Silent_p.L191L	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	1258	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						TTTTACAGTTGAAGGCACAGT	0.368			T	RET	papillary thryoid								0	0	0	0.014323	0	22	32										A	56142555	G	A	56142555	2	1	116	1	0	0	0	0	0	0	0	1	8585	1281	45	1		1	KTN1	14	56142555	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	24516116	56142555	51206985	245	34879										
KIAA0586	9786	broad.mit.edu	37	chr14	58954657	58954657	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	actccaacagttacccctacTactacacctcctccagcggc	4	19	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:58954657T>G	uc001xdv.3	+	22	3402	c.3129T>G	c.(3127-3129)ACT>ACG	p.T1043T	KIAA0586_uc010trr.1_Silent_p.T1160T|KIAA0586_uc001xdt.3_Silent_p.T1075T|KIAA0586_uc001xdu.3_Silent_p.T1104T|KIAA0586_uc010trs.1_Silent_p.T1034T|KIAA0586_uc010trt.1_Silent_p.T979T|KIAA0586_uc010tru.1_Silent_p.T979T	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	1043										ovary(1)	1						TTACCCCTACTACTACACCTC	0.418													0	0	0	0.010729	0	10	19										G	58954657	T	G	58954657	2	3	116	1	0	0	0	0	0	0	0	1	8186	1509	53	5		5	KIAA0586	14	58954657	Silent	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	2812102	58954657	48394883	246	34880										
SYNE2	23224	broad.mit.edu	37	chr14	64619413	64619413	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attgatgagttatttcaaaaGagaagcagtgttctcactca	8	6	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:64619413G>C	uc001xgm.2	+	85	16001	c.15771G>C	c.(15769-15771)AAG>AAC	p.K5257N	SYNE2_uc001xgl.2_Missense_Mutation_p.K5257N|SYNE2_uc010apy.2_Missense_Mutation_p.K1642N|SYNE2_uc001xgn.2_Missense_Mutation_p.K219N|SYNE2_uc001xgo.2_RNA	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5257	Spectrin 3.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TATTTCAAAAGAGAAGCAGTG	0.373													0	0	0	0.001984	0	5	85										C	64619413	G	C	64619413	3	2	116	1	0	0	0	0	1	0	0	0	15443	933	33	1	16105	1	SYNE2	14	64619413	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5664756	64619413	42730127	247	34881										
ZFYVE26	23503	broad.mit.edu	37	chr14	68260378	68260378	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcaggatgccagcagtgactCaggtggggagaacatcatgg	16	8	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:68260378C>G	uc001xka.2	-	14	2639	c.2500G>C	c.(2500-2502)GAG>CAG	p.E834Q	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.E834Q	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	834					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGCAGTGACTCAGGTGGGGAG	0.552													0	0	0	0.01441	0	44	24										G	68260378	C	G	68260378	3	3	116	1	0	0	0	0	1	0	0	0	17665	835	29	1	5235	1	ZFYVE26	14	68260378	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3640965	68260378	39089162	248	34882										
PSEN1	5663	broad.mit.edu	37	chr14	73637508	73637508	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttttcttgtgcttatagaatGacaatagagaacggcaggag	11	5	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:73637508G>A	uc001xnr.2	+	4	375	c.91G>A	c.(91-93)GAC>AAC	p.D31N	PSEN1_uc001xnv.2_Missense_Mutation_p.D27N|PSEN1_uc010ark.2_Missense_Mutation_p.D27N|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA|PSEN1_uc001xnq.3_Missense_Mutation_p.D31N	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	31	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		CTTATAGAATGACAATAGAGA	0.483													0	0	0	0.000602	0	4	39										A	73637508	G	A	73637508	3	1	116	1	0	0	0	0	1	0	0	0	12650	1290	45	1	97	1	PSEN1	14	73637508	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5377130	73637508	33712032	249	34883										
LIN52	91750	broad.mit.edu	37	chr14	74567922	74567922	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggcctacagaacctagcctaTcagctggggctggatgagtg	14	10	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:74567922T>C	uc001xpp.2	+	5	286	c.276T>C	c.(274-276)TAT>TAC	p.Y92Y	LIN52_uc010asb.2_Intron	NM_001024674	NP_001019845	Q52LA3	LIN52_HUMAN	lin-52 homolog	92										breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00471)		ACCTAGCCTATCAGCTGGGGC	0.488													0	0	0	0.012213	0	28	71										C	74567922	T	C	74567922	2	2	116	1	0	0	0	0	0	0	0	1	8808	1442	50	5		5	LIN52	14	74567922	Silent	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	930414	74567922	32781618	250	34884										
C14orf115	55237	broad.mit.edu	37	chr14	74825046	74825046	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gctgcccgcaggcaggtgctGagtgggcatctccctttctg	14	13	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:74825046G>C	uc001xpw.3	+	2	1751	c.1560G>C	c.(1558-1560)CTG>CTC	p.L520L		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	520					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		GGCAGGTGCTGAGTGGGCATC	0.672													0	0	0	0.01441	0	43	100										C	74825046	G	C	74825046	2	2	116	1	0	0	0	0	0	0	0	1	1740	1277	45	1		1	C14orf115	14	74825046	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	257124	74825046	32524494	251	34885										
GSTZ1	2954	broad.mit.edu	37	chr14	77797454	77797454	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	taccctaccatcagctccatCaacaagaggctgctggtctt	7	14	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:77797454C>G	uc001xtj.2	+	9	849	c.567C>G	c.(565-567)ATC>ATG	p.I189M	GSTZ1_uc001xtk.2_Missense_Mutation_p.I147M|GSTZ1_uc010ass.2_Missense_Mutation_p.I134M|GSTZ1_uc001xtm.2_Missense_Mutation_p.I134M	NM_145870	NP_665877	O43708	MAAI_HUMAN	glutathione transferase zeta 1 isoform 1	189	GST C-terminal.				glutathione metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol|mitochondrion	glutathione peroxidase activity|glutathione transferase activity|maleylacetoacetate isomerase activity|protein homodimerization activity				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)	Glutathione(DB00143)	TCAGCTCCATCAACAAGAGGC	0.567													0	0	0	0.01441	0	54	47										G	77797454	C	G	77797454	3	3	116	1	0	0	0	0	1	0	0	0	6848	816	29	1	601	1	GSTZ1	14	77797454	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2972408	77797454	29552086	252	34886										
SERPINA9	327657	broad.mit.edu	37	chr14	94936059	94936059	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggaatacacctgtgaggcaGgggtgctctttgtggaggaa	17	6	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:94936059G>C	uc001ydf.2	-	2	334	c.173C>G	c.(172-174)CCT>CGT	p.P58R	SERPINA9_uc001yde.2_Missense_Mutation_p.P58R|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.P58R|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	40					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		CTGTGAGGCAGGGGTGCTCTT	0.577													0	0	0	0.013537	0	10	73										C	94936059	G	C	94936059	3	2	116	1	0	0	0	0	1	0	0	0	14095	1000	35	4	1150	4	SERPINA9	14	94936059	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	17138605	94936059	12413481	253	34887										
RAGE	5891	broad.mit.edu	37	chr14	102718331	102718331	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tctgataatgggtatcttctCcctgtacaatcaaggaaata	7	8	4	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:102718331C>G	uc001ylm.2	-	5	511	c.285G>C	c.(283-285)GGG>GGC	p.G95G	RAGE_uc010txv.1_Silent_p.G65G|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	95	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GGTATCTTCTCCCTGTACAAT	0.318													0	0	0	0.001168	0	5	71										G	102718331	C	G	102718331	2	3	116	1	0	0	0	0	0	0	0	1	13006	869	30	1		1	RAGE	14	102718331	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	7782272	102718331	4631209	254	34888										
KIF26A	26153	broad.mit.edu	37	chr14	104642805	104642805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cacccgtgtgggctgtgctcGcctgggccagagcccacctg	14	16	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr14:104642805G>A	uc001yos.3	+	12	3680	c.3680G>A	c.(3679-3681)CGC>CAC	p.R1227H		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1227					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGCTGTGCTCGCCTGGGCCAG	0.701													0	0	0	0.00499	0	16	21										A	104642805	G	A	104642805	3	1	116	1	0	0	0	0	1	0	0	0	8294	1087	38	2	3726	2	KIF26A	14	104642805	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1924474	104642805	2706735	255	34889										
NUSAP1	51203	broad.mit.edu	37	chr15	41657646	41657646	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caggactccagtacctccaaGaggaagactctctgtggctt	10	12	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:41657646G>C	uc001zns.3	+	7	937	c.707G>C	c.(706-708)AGA>ACA	p.R236T	NUSAP1_uc001znq.3_Missense_Mutation_p.R41T|NUSAP1_uc001znr.3_Missense_Mutation_p.R235T|NUSAP1_uc010bce.2_Missense_Mutation_p.R236T|NUSAP1_uc001znt.3_Missense_Mutation_p.R221T|NUSAP1_uc001znv.3_Missense_Mutation_p.R234T|NUSAP1_uc001znu.3_Missense_Mutation_p.R235T|NUSAP1_uc010ucw.1_Missense_Mutation_p.R212T|NUSAP1_uc001znw.3_Missense_Mutation_p.R40T	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	236					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		GTACCTCCAAGAGGAAGACTC	0.493													0	0	0	0.00308	0	6	6										C	41657646	G	C	41657646	3	2	116	1	0	0	0	0	1	0	0	0	10778	942	33	1	733	1	NUSAP1	15	41657646	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		41657646	60873746	256	34890										
SHC4	399694	broad.mit.edu	37	chr15	49255156	49255156	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgcagcatcccggggtgcccGaagagtcctacatacagcac	11	14	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:49255156G>T	uc001zxb.1	-	1	486	c.57C>A	c.(55-57)TTC>TTA	p.F19L		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	19	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		CGGGGTGCCCGAAGAGTCCTA	0.592													1	0	4.85316e-53	0.01441	5.28836e-53	81	27										T	49255156	G	T	49255156	3	4	116	1	0	0	0	0	1	0	0	0	14273	1049	37	3	1883	3	SHC4	15	49255156	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	7597510	49255156	53276236	257	34891										
IGDCC4	57722	broad.mit.edu	37	chr15	65702611	65702611	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcaaagcgagctgtcccgttCtcctccaccgtctgagactc	8	16	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:65702611C>T	uc002aou.1	-	3	678	c.468G>A	c.(466-468)GAG>GAA	p.E156E		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	156	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane		p.E156V(1)		ovary(1)|pancreas(1)|skin(1)	3						CTGTCCCGTTCTCCTCCACCG	0.577													0	0	0	0.000602	0	3	59										T	65702611	C	T	65702611	2	4	116	1	0	0	0	0	0	0	0	1	7569	912	32	1		1	IGDCC4	15	65702611	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16447455	65702611	36828781	258	34892										
MPI	4351	broad.mit.edu	37	chr15	75183866	75183866	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aatggcaacctgcccttcctCttcaaagtgctctcagttga	7	13	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:75183866C>T	uc002azc.1	+	3	296	c.291C>T	c.(289-291)CTC>CTT	p.L97L	MPI_uc010ulv.1_Silent_p.L97L|MPI_uc010ulw.1_Silent_p.L47L|MPI_uc002azd.1_Silent_p.L97L|MPI_uc010ulx.1_Silent_p.L47L|MPI_uc002aze.1_Silent_p.L97L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	97					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						TGCCCTTCCTCTTCAAAGTGC	0.527													0	0	0	0.006122	0	18	108										T	75183866	C	T	75183866	2	4	116	1	0	0	0	0	0	0	0	1	9729	900	32	1		1	MPI	15	75183866	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	9481255	75183866	27347526	259	34893										
UNC45A	55898	broad.mit.edu	37	chr15	91483695	91483695	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttggcatttgctctgagcatCagtcacgggtaggtggagtg	15	7	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr15:91483695C>G	uc002bqg.2	+	6	1019	c.679C>G	c.(679-681)CAG>GAG	p.Q227E	UNC45A_uc002bqd.2_Missense_Mutation_p.Q212E|UNC45A_uc010uqo.1_Missense_Mutation_p.Q219E|UNC45A_uc010uqp.1_RNA|UNC45A_uc010uqq.1_Missense_Mutation_p.Q227E	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	227					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CTCTGAGCATCAGTCACGGGT	0.433													0	0	0	0.00308	0	6	37										G	91483695	C	G	91483695	3	3	116	1	0	0	0	0	1	0	0	0	16985	827	29	1	701	1	UNC45A	15	91483695	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16299829	91483695	11047697	260	34894										
WDR90	197335	broad.mit.edu	37	chr16	700002	700002	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttctccaggacaagaccctGaagggcgccgtgtatcgcat	11	13	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:700002G>A	uc002cii.1	+	3	168	c.114G>A	c.(112-114)CTG>CTA	p.L38L	WDR90_uc002cig.1_Silent_p.L38L|WDR90_uc002cih.1_Silent_p.L38L|WDR90_uc002cij.1_RNA	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	38										ovary(1)	1		Hepatocellular(780;0.0218)				ACAAGACCCTGAAGGGCGCCG	0.667													0	0	0	0.008291	0	11	53										A	700002	G	A	700002	2	1	116	1	0	0	0	0	0	0	0	1	17334	1277	45	1		1	WDR90	16	700002	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		700002	89654751	261	34895										
UNKL	64718	broad.mit.edu	37	chr16	1464642	1464643	+	Frame_Shift_Ins	INS	-	-	G													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggtcggcttctcagtctgcINSgggggggacccgctcagcgc							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:1464642_1464643insG	uc010bro.1	-	1	58_59	c.50_51insC	c.(49-51)CCGfs	p.P17fs	UNKL_uc002clq.2_Frame_Shift_Ins_p.P17fs	NM_001037125	NP_001032202	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 2	17						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				TCTCAGTCTGCGGGGGGGACCC	0.332																		2	4	---	---								G	1464643	-	G	1464642	7	5	116	1	0	1	1	0	0	0	0	0	16998	755	27	0	1521	0	UNKL	16	1464642	Frame_Shift_Ins	INS	-	TCGA-GV-A3JX-01A-11D-A20D-08	764640	1464642	88890111	262	34896										
TIGD7	91151	broad.mit.edu	37	chr16	3349173	3349173	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaaggtagtccaaactctctCttacagcagataatttaaat	6	8	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:3349173C>T	uc002cus.2	-	1	2228	c.1442G>A	c.(1441-1443)AGA>AAA	p.R481K	ZNF263_uc002cur.2_3'UTR	NM_033208	NP_149985	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	481					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CAAACTCTCTCTTACAGCAGA	0.393													0	0	0	0.01441	0	74	15										T	3349173	C	T	3349173	3	4	116	1	0	0	0	0	1	0	0	0	15898	913	32	1	211	1	TIGD7	16	3349173	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1884531	3349173	87005580	263	34897										
CREBBP	1387	broad.mit.edu	37	chr16	3820785	3820785	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cggaagacgacacaggagttGatggctgagtgggagctgct	17	7	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:3820785G>C	uc002cvv.2	-	14	2870	c.2666C>G	c.(2665-2667)TCA>TGA	p.S889*	CREBBP_uc002cvw.2_Nonsense_Mutation_p.S851*	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	889					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CACAGGAGTTGATGGCTGAGT	0.642			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.00308	0	6	35										C	3820785	G	C	3820785	4	2	116	1	0	0	0	0	0	1	0	0	3861	1294	45	1	4734	1	CREBBP	16	3820785	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	471612	3820785	86533968	264	34898										
GP2	2813	broad.mit.edu	37	chr16	20331027	20331027	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gttgatgttgaggatggtgtCtctgatgatgaaatcattga	13	3	2	6			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:20331027C>G	uc002dgv.2	-	7	1014	c.931G>C	c.(931-933)GAC>CAC	p.D311H	GP2_uc002dgw.2_Missense_Mutation_p.D308H|GP2_uc002dgx.2_Missense_Mutation_p.D164H|GP2_uc002dgy.2_Missense_Mutation_p.D161H	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	311	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						AGGATGGTGTCTCTGATGATG	0.438													0	0	0	0.01441	0	117	23										G	20331027	C	G	20331027	3	3	116	1	0	0	0	0	1	0	0	0	6582	913	32	1	706	1	GP2	16	20331027	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16510242	20331027	70023726	265	34899										
ACSM2B	348158	broad.mit.edu	37	chr16	20552067	20552067	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggtcatgggataggaactgcGaggccaggatcacaaatgcc	14	9	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:20552067G>T	uc002dhj.3	-	14	1748	c.1538C>A	c.(1537-1539)TCG>TAG	p.S513*	ACSM2B_uc002dhk.3_Nonsense_Mutation_p.S513*	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	513					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TAGGAACTGCGAGGCCAGGAT	0.478													1	0	8.16569e-41	0.01441	8.77867e-41	67	13										T	20552067	G	T	20552067	4	4	116	1	0	0	0	0	0	1	0	0	184	1059	37	3	203	3	ACSM2B	16	20552067	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	221040	20552067	69802686	266	34900										
ZNF689	115509	broad.mit.edu	37	chr16	30616005	30616005	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtgtgcaagagctggtgctgGagcagcgtgctgcgctggga	19	8	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:30616005G>C	uc002dyx.2	-	3	1403	c.1083C>G	c.(1081-1083)CTC>CTG	p.L361L	ZNF689_uc010bzy.2_Missense_Mutation_p.S17C	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	361	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GCTGGTGCTGGAGCAGCGTGC	0.687													0	0	0	0.009096	0	2	9										C	30616005	G	C	30616005	2	2	116	1	0	0	0	0	0	0	0	1	18091	1161	41	1		1	ZNF689	16	30616005	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	10063938	30616005	59738748	267	34901										
ZNF689	115509	broad.mit.edu	37	chr16	30616651	30616651	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagggcagatggggcccccgGacgtctgcctaggaatcagt	15	12	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:30616651G>A	uc002dyx.2	-	3	757	c.437C>T	c.(436-438)TCC>TTC	p.S146F	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GGGGCCCCCGGACGTCTGCCT	0.602													0	0	0	0.003163	0	12	76										A	30616651	G	A	30616651	3	1	116	1	0	0	0	0	1	0	0	0	18091	1174	41	1	1069	1	ZNF689	16	30616651	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	646	30616651	59738102	268	34902										
KCTD19	146212	broad.mit.edu	37	chr16	67323532	67323532	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acagacctagacaggcccctCtggatgagcaggtccatgca	11	13	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:67323532C>G	uc002esu.2	-	16	2772	c.2721G>C	c.(2719-2721)CAG>CAC	p.Q907H	KCTD19_uc002est.2_Missense_Mutation_p.Q679H|KCTD19_uc010vjj.1_Missense_Mutation_p.Q650H	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	907						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		ACAGGCCCCTCTGGATGAGCA	0.562													0	0	0	0.01441	0	60	15										G	67323532	C	G	67323532	3	3	116	1	0	0	0	0	1	0	0	0	8106	912	32	1	63	1	KCTD19	16	67323532	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	36706881	67323532	23031221	269	34903										
CDH13	1012	broad.mit.edu	37	chr16	83704469	83704469	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaagataaggatgaccccacCacaggtgcatggagggctgc	14	10	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr16:83704469C>T	uc002fgx.2	+	9	1296	c.1176C>T	c.(1174-1176)ACC>ACT	p.T392T	CDH13_uc010vns.1_Silent_p.T439T|CDH13_uc010vnt.1_Silent_p.T138T|CDH13_uc010vnu.1_Silent_p.T353T	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	392	Cadherin 3.			T -> A (in Ref. 4; AAH28624/AAH30653).	adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		ATGACCCCACCACAGGTGCAT	0.498													0	0	0	0.01441	0	47	6										T	83704469	C	T	83704469	2	4	116	1	0	0	0	0	0	0	0	1	3099	581	21	2		2	CDH13	16	83704469	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16380937	83704469	6650284	270	34904										
MYO1C	4641	broad.mit.edu	37	chr17	1370776	1370776	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggccgcccgcgcctcacctGccctggttgatgttgatgct	13	15	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:1370776G>A	uc002fsp.2	-	30	3283	c.3063C>T	c.(3061-3063)GGC>GGT	p.G1021G	MYO1C_uc002fsn.2_Silent_p.G1002G|MYO1C_uc002fso.2_Silent_p.G986G	NM_001080779	NP_001074248	O00159	MYO1C_HUMAN	myosin IC isoform a	1021					mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGCCTCACCTGCCCTGGTTGA	0.677													0	0	0	0.010729	0	10	68										A	1370776	G	A	1370776	2	1	116	1	0	0	0	0	0	0	0	1	10070	1306	46	2		2	MYO1C	17	1370776	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		1370776	79824434	271	34905										
TEKT1	83659	broad.mit.edu	37	chr17	6703366	6703366	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttagcagacagcatcagggcGgaggcccccagcccagaccc	12	16	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:6703366G>A	uc002gdt.2	-	8	1347	c.1237C>T	c.(1237-1239)CGC>TGC	p.R413C	TEKT1_uc010vth.1_Missense_Mutation_p.R267C	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	413					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				GCATCAGGGCGGAGGCCCCCA	0.488													0	0	0	0.01441	0	63	105										A	6703366	G	A	6703366	3	1	116	1	0	0	0	0	1	0	0	0	15749	1116	39	2	23	2	TEKT1	17	6703366	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5332590	6703366	74491844	272	34906										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	63	11										T	7577538	C	T	7577538	3	4	116	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	874172	7577538	73617672	273	34907										
PIGL	9487	broad.mit.edu	37	chr17	16137360	16137360	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgttttggggattccactctCcagtgtaatgattattgaca	9	7	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:16137360C>G	uc002gpv.2	+	2	343	c.311C>G	c.(310-312)TCC>TGC	p.S104C	PIGL_uc010vwd.1_Missense_Mutation_p.S104C	NM_004278	NP_004269	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	104	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		ATTCCACTCTCCAGTGTAATG	0.333													0	0	0	0.01441	0	79	8										G	16137360	C	G	16137360	3	3	116	1	0	0	0	0	1	0	0	0	11891	855	30	1	317	1	PIGL	17	16137360	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	8559822	16137360	65057850	274	34908										
FAM83G	644815	broad.mit.edu	37	chr17	18880947	18880947	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgcatcctcttcaacgcatCtgcttcttctcttccccgac	4	18	5	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:18880947C>G	uc002guw.2	-	5	2199	c.2032G>C	c.(2032-2034)GAT>CAT	p.D678H	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	678										ovary(1)|central_nervous_system(1)	2						TTCAACGCATCTGCTTCTTCT	0.652													0	0	0	0.013537	0	10	60										G	18880947	C	G	18880947	3	3	116	1	0	0	0	0	1	0	0	0	5639	913	32	1	447	1	FAM83G	17	18880947	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2743587	18880947	62314263	275	34909										
MAPK7	5598	broad.mit.edu	37	chr17	19285429	19285429	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccccagtccaacctaccagtCctcctcctggccctgtagcc	6	21	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:19285429C>T	uc002gvn.2	+	5	2199	c.1813C>T	c.(1813-1815)CCT>TCT	p.P605S	MAPK7_uc002gvo.2_Missense_Mutation_p.P466S|MAPK7_uc002gvq.2_Missense_Mutation_p.P605S|MAPK7_uc002gvp.2_Missense_Mutation_p.P605S|uc010vyt.1_5'Flank	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	605	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).|Pro-rich.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					ACCTACCAGTCCTCCTCCTGG	0.423													0	0	0	0.003163	0	13	0										T	19285429	C	T	19285429	3	4	116	1	0	0	0	0	1	0	0	0	9282	855	30	1	1827	1	MAPK7	17	19285429	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	404482	19285429	61909781	276	34910										
DHRS7B	25979	broad.mit.edu	37	chr17	21086979	21086979	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccatagttgcagcagcagctGagatcctgcagtgctttggc	12	11	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:21086979G>A	uc002gyo.2	+	4	409	c.382G>A	c.(382-384)GAG>AAG	p.E128K		NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	128	Peroxisomal (Potential).					integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			pancreas(1)	1						AGCAGCAGCTGAGATCCTGCA	0.498													0	0	0	0.009535	0	27	37										A	21086979	G	A	21086979	3	1	116	1	0	0	0	0	1	0	0	0	4496	1291	45	1	396	1	DHRS7B	17	21086979	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1801550	21086979	60108231	277	34911										
RAB11FIP4	84440	broad.mit.edu	37	chr17	29857477	29857477	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgcggagatagacaccgcctCgcgcgatgaggtaaccacac	12	13	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:29857477C>T	uc002hgn.1	+	14	2016	c.1787C>T	c.(1786-1788)TCG>TTG	p.S596L	RAB11FIP4_uc002hgo.2_Missense_Mutation_p.S494L	NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	596	Potential.|Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.|FIP-RBD.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GACACCGCCTCGCGCGATGAG	0.582													0	0	0	0.01441	0	67	61										T	29857477	C	T	29857477	3	4	116	1	0	0	0	0	1	0	0	0	12896	893	31	1	1841	1	RAB11FIP4	17	29857477	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	8770498	29857477	51337733	278	34912										
RAD51L3	5892	broad.mit.edu	37	chr17	33430494	33430494	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttccctctgctgacctcccaGaagtggggaaaccaccgcag	10	15	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:33430494G>A	uc002hir.2	-	7	902	c.646C>T	c.(646-648)CTG>TTG	p.L216L	RFFL_uc002hiq.2_Silent_p.L57L|RAD51L3_uc010ctj.2_Missense_Mutation_p.S34F|RAD51L3_uc010wcd.1_Silent_p.L236L|RAD51L3_uc002his.2_Silent_p.L104L|RAD51L3_uc010ctk.2_Silent_p.L97L|RAD51L3_uc010wce.1_Silent_p.L97L|RAD51L3_uc002hit.2_Silent_p.L97L|RAD51L3_uc002hiu.2_Silent_p.L39L	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	216					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		TGACCTCCCAGAAGTGGGGAA	0.592								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.01441	0	47	66										A	33430494	G	A	33430494	2	1	116	1	0	0	0	0	0	0	0	1	12990	933	33	1		1	RAD51L3	17	33430494	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	3573017	33430494	47764716	279	34913										
MED1	5469	broad.mit.edu	37	chr17	37587411	37587411	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccaacacttccatgaagaatCttatccaagggaccagcatt	6	12	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:37587411C>G	uc002hrv.3	-	9	818	c.606G>C	c.(604-606)AAG>AAC	p.K202N	MED1_uc010wee.1_Missense_Mutation_p.K30N|MED1_uc002hru.2_Missense_Mutation_p.K202N	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	202	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		CATGAAGAATCTTATCCAAGG	0.393										HNSCC(31;0.082)			0	0	0	0.01441	0	83	114										G	37587411	C	G	37587411	3	3	116	1	0	0	0	0	1	0	0	0	9425	912	32	1	4175	1	MED1	17	37587411	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4156917	37587411	43607799	280	34914										
KRT33A	3883	broad.mit.edu	37	chr17	39502796	39502796	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cctgatactcctggttctgcCgctccaggtcactgcggatc	10	15	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:39502796C>A	uc002hwk.1	-	6	1038	c.1001G>T	c.(1000-1002)CGG>CTG	p.R334L		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	334	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				CTGGTTCTGCCGCTCCAGGTC	0.632													1	0	5.78178e-49	0.01441	6.24931e-49	84	108										A	39502796	C	A	39502796	3	1	116	1	0	0	0	0	1	0	0	0	8469	652	23	4	221	4	KRT33A	17	39502796	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1915385	39502796	41692414	281	34915										
KRT34	3885	broad.mit.edu	37	chr17	39538044	39538044	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attctcagccttggcacacaGaatctgaaaagaaatttctc	6	10	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:39538044G>C	uc002hwm.2	-	2	490	c.478C>G	c.(478-480)CTG>GTG	p.L160V		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	160	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TTGGCACACAGAATCTGAAAA	0.483													0	0	0	0.01441	0	39	45										C	39538044	G	C	39538044	3	2	116	1	0	0	0	0	1	0	0	0	8471	933	33	1	856	1	KRT34	17	39538044	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	35248	39538044	41657166	282	34916										
UBTF	7343	broad.mit.edu	37	chr17	42284923	42284923	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atcttcctcttcttcatcctCgtcctcgtcatcctcatcct	2	18	6	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:42284923C>T	uc002igb.2	-	19	2135	c.2068G>A	c.(2068-2070)GAG>AAG	p.E690K	UBTF_uc002igc.2_Missense_Mutation_p.E653K|UBTF_uc010czs.2_Missense_Mutation_p.E690K|UBTF_uc002igd.2_Missense_Mutation_p.E653K|UBTF_uc010czt.2_Missense_Mutation_p.E690K	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	690	Asp/Glu/Ser-rich (acidic).				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		tcttcatcctcgtcctcgtca	0.428													0	0	0	0.004007	0	16	26										T	42284923	C	T	42284923	3	4	116	1	0	0	0	0	1	0	0	0	16906	893	31	1	234	1	UBTF	17	42284923	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2746879	42284923	38910287	283	34917										
MAPT	4137	broad.mit.edu	37	chr17	44067367	44067368	+	Missense_Mutation	DNP	CC	CC	AT													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctgctgtgtgcccagagccaCcttcctctcctaaatacgtc							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:44067367_44067368CC>AT	uc002ijr.3	+	8	1626_1627	c.1306_1307CC>AT	c.(1306-1308)CCT>ATT	p.P436I	MAPT_uc010dau.2_Missense_Mutation_p.P436I|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	436					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CCCAGAGCCACCTTCCTCTCCT	0.515													0	0	0	0.004672	0	126	151										AT	44067368	CC	AT	44067367	3	1	116	1	0	0	0	0	1	0	0	0	9297	507	18	4	1332	4	MAPT	17	44067367	Missense_Mutation	DNP	CC	TCGA-GV-A3JX-01A-11D-A20D-08	1782444	44067367	37127843	284	34918										
MAPT	4137	broad.mit.edu	37	chr17	44067427	44067427	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctggcagttctggagcaaagGagatgaaactcaaggtaagg	14	6	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:44067427G>A	uc002ijr.3	+	8	1686	c.1366G>A	c.(1366-1368)GAG>AAG	p.E456K	MAPT_uc010dau.2_Missense_Mutation_p.E456K|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	456					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				TGGAGCAAAGGAGATGAAACT	0.453													0	0	0	0.00623	0	31	44										A	44067427	G	A	44067427	3	1	116	1	0	0	0	0	1	0	0	0	9297	1175	41	1	1392	1	MAPT	17	44067427	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	60	44067427	37127783	285	34919										
TTLL6	284076	broad.mit.edu	37	chr17	46863537	46863537	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caggtttacctgtttggaggCttgggtggcggccttgtctt	15	8	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:46863537C>T	uc010wlo.1	-	13	1785	c.1750G>A	c.(1750-1752)GCC>ACC	p.A584T	TTLL6_uc002iob.2_Missense_Mutation_p.A277T|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.A337T|TTLL6_uc002iod.2_Missense_Mutation_p.A431T	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	536						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						TGTTTGGAGGCTTGGGTGGCG	0.587													0	0	0	0.01441	0	231	305										T	46863537	C	T	46863537	3	4	116	1	0	0	0	0	1	0	0	0	16728	797	28	2	941	2	TTLL6	17	46863537	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2796110	46863537	34331673	286	34920										
SPOP	8405	broad.mit.edu	37	chr17	47699430	47699430	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gagaatttcactaccttgatCtgttgatagaaaaacaggaa	8	6	2	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:47699430C>A	uc010dbk.2	-	4	711	c.79_splice	c.e4-1	p.I27_splice	SPOP_uc002ipb.2_Splice_Site_p.I27_splice|SPOP_uc002ipc.2_Splice_Site_p.I27_splice|SPOP_uc002ipd.2_Splice_Site_p.I27_splice|SPOP_uc002ipe.2_Splice_Site_p.I27_splice|SPOP_uc002ipf.2_Splice_Site_p.I27_splice|SPOP_uc002ipg.2_Splice_Site_p.I27_splice	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein						mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						CTACCTTGATCTGTTGATAGA	0.398										Prostate(2;0.17)			1	0	5.03518e-11	0.007413	5.31344e-11	14	21										A	47699430	C	A	47699430	5	1	116	1	0	0	0	0	0	0	1	0	15083	927	32	3	1078	3	SPOP	17	47699430	Splice_Site	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	835893	47699430	33495780	287	34921										
UTP18	51096	broad.mit.edu	37	chr17	49337968	49337968	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gccgccggagcggaggagacGaatgaaactggaccggagaa	17	9	0	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:49337968G>A	uc002its.2	+	1	72	c.23G>A	c.(22-24)CGA>CAA	p.R8Q	MBTD1_uc002itr.3_5'Flank|MBTD1_uc002itq.3_5'Flank	NM_016001	NP_057085	Q9Y5J1	UTP18_HUMAN	UTP18, small subunit processome component	8					rRNA processing	nucleolus					0			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			CGGAGGAGACGAATGAAACTG	0.687													0	0	0	0.006214	0	7	19										A	49337968	G	A	49337968	3	1	116	1	0	0	0	0	1	0	0	0	17095	1058	37	1	25	1	UTP18	17	49337968	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	1638538	49337968	31857242	288	34922										
MARCH10	162333	broad.mit.edu	37	chr17	60813767	60813767	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtcgatgacattgacaagtCtactggaatatcatctctca	7	9	4	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:60813767C>A	uc010ddr.2	-	6	1700	c.1462G>T	c.(1462-1464)GAC>TAC	p.D488Y	MARCH10_uc002jag.3_Missense_Mutation_p.D488Y|MARCH10_uc010dds.2_Missense_Mutation_p.D526Y|MARCH10_uc002jah.2_Missense_Mutation_p.D487Y|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	488							ligase activity|zinc ion binding				0						ATTGACAAGTCTACTGGAATA	0.433													1	0	6.31663e-08	0.003163	6.56209e-08	13	133										A	60813767	C	A	60813767	3	1	116	1	0	0	0	0	1	0	0	0	9299	913	32	3	988	3	MARCH10	17	60813767	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	11475799	60813767	20381443	289	34923										
GPR142	350383	broad.mit.edu	37	chr17	72368385	72368385	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cggctacggaggaggggccgGagtgggctgcagccccgggt	21	11	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:72368385G>A	uc010wqy.1	+	4	1035	c.1035G>A	c.(1033-1035)CGG>CGA	p.R345R	GPR142_uc010wqx.1_Silent_p.R257R	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	345	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GGAGGGGCCGGAGTGGGCTGC	0.627													0	0	0	0.00632	0	27	33										A	72368385	G	A	72368385	2	1	116	1	0	0	0	0	0	0	0	1	6650	1161	41	1		1	GPR142	17	72368385	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	11554618	72368385	8826825	290	34924										
NUP85	79902	broad.mit.edu	37	chr17	73231773	73231773	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aggctcactggaaggttcctGagaactgcttcaatgtggta	12	8	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:73231773G>A	uc002jng.1	+	19	2230	c.1970G>A	c.(1969-1971)TGA>TAA	p.*657*	NUP85_uc010dgd.1_Silent_p.*612*|NUP85_uc010wrv.1_Silent_p.*611*|NUP85_uc002jnh.1_Silent_p.*260*	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	657					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GAAGGTTCCTGAGAACTGCTT	0.398													0	0	0	0.008291	0	8	70										A	73231773	G	A	73231773	2	1	116	1	0	0	0	0	0	0	0	1	10770	1285	45	1		1	NUP85	17	73231773	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	863388	73231773	7963437	291	34925										
SAP30BP	29115	broad.mit.edu	37	chr17	73695901	73695901	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttcggaacatgtcgcctgatGaaatcaagatcccgccagaa	9	11	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:73695901G>A	uc002jpe.2	+	5	400	c.346G>A	c.(346-348)GAA>AAA	p.E116K	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.E100K	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	116					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTCGCCTGATGAAATCAAGAT	0.428													0	0	0	0.01441	0	73	175										A	73695901	G	A	73695901	3	1	116	1	0	0	0	0	1	0	0	0	13834	1291	45	1	364	1	SAP30BP	17	73695901	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	464128	73695901	7499309	292	34926										
SAP30BP	29115	broad.mit.edu	37	chr17	73695932	73695932	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cccgccagaaccccctggcaGatgttcaaatcacttgcaag	8	15	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:73695932G>C	uc002jpe.2	+	5	431	c.377G>C	c.(376-378)AGA>ACA	p.R126T	SAP30BP_uc002jpc.1_RNA|SAP30BP_uc010wsf.1_RNA|SAP30BP_uc010wsg.1_RNA|SAP30BP_uc002jpf.2_Missense_Mutation_p.R110T	NM_013260	NP_037392	Q9UHR5	S30BP_HUMAN	transcriptional regulator protein	126					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCCCTGGCAGATGTTCAAAT	0.453													0	0	0	0.01441	0	53	152										C	73695932	G	C	73695932	3	2	116	1	0	0	0	0	1	0	0	0	13834	942	33	1	395	1	SAP30BP	17	73695932	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	31	73695932	7499278	293	34927										
EIF4A3	9775	broad.mit.edu	37	chr17	78111277	78111277	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acagtgaagttggcttccctCattttctccgtcagccagtc	8	13	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr17:78111277C>T	uc010wuc.1	-	10	964	c.891G>A	c.(889-891)ATG>ATA	p.M297I	EIF4A3_uc002jxs.2_Missense_Mutation_p.M297I	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	297	Helicase C-terminal.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TGGCTTCCCTCATTTTCTCCG	0.517													0	0	0	0.00632	0	24	24										T	78111277	C	T	78111277	3	4	116	1	0	0	0	0	1	0	0	0	5026	826	29	1	360	1	EIF4A3	17	78111277	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4415345	78111277	3083933	294	34928										
NDC80	10403	broad.mit.edu	37	chr18	2578034	2578034	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tacaagctccctctgttaaaGacttcctgaagatcttcaca	5	12	3	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:2578034G>C	uc002kli.2	+	5	552	c.370G>C	c.(370-372)GAC>CAC	p.D124H		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	124	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						CTCTGTTAAAGACTTCCTGAA	0.368													0	0	0	0.006214	0	8	246										C	2578034	G	C	2578034	3	2	116	1	0	0	0	0	1	0	0	0	10242	942	33	1	384	1	NDC80	18	2578034	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		2578034	75499214	295	34929										
LPIN2	9663	broad.mit.edu	37	chr18	2921615	2921615	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcatttagacactcaattttGaacttctctggtttcttttc	4	9	4	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:2921615G>A	uc002klo.2	-	18	2597	c.2358C>T	c.(2356-2358)TTC>TTT	p.F786F		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	786	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		ACTCAATTTTGAACTTCTCTG	0.393													0	0	0	0.004482	0	8	204										A	2921615	G	A	2921615	2	1	116	1	0	0	0	0	0	0	0	1	8919	1281	45	1		1	LPIN2	18	2921615	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	343581	2921615	75155633	296	34930										
EPB41L3	23136	broad.mit.edu	37	chr18	5489114	5489114	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cccgcgcgcccctgcgccccCgccgcctcctggggctcggc	13	24	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:5489114C>A	uc002kmt.1	-	2	155	c.69G>T	c.(67-69)GCG>GCT	p.A23A	EPB41L3_uc010wzh.1_Silent_p.A23A|EPB41L3_uc002kmu.1_Silent_p.A23A|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Silent_p.A45A|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	23					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						cctgcgcccccgccgccTCCT	0.517													1	0	1.30293e-26	0.003271	1.397e-26	31	57										A	5489114	C	A	5489114	2	1	116	1	0	0	0	0	0	0	0	1	5154	639	23	4		4	EPB41L3	18	5489114	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2567499	5489114	72588134	297	34931										
PPP4R1	9989	broad.mit.edu	37	chr18	9570582	9570582	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcagcagcatggtcttccatCgtgttttccagtatgacact	8	11	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:9570582C>T	uc002koe.1	-	11	1264	c.1146G>A	c.(1144-1146)ACG>ACA	p.T382T	PPP4R1_uc002kof.2_5'UTR|PPP4R1_uc010wzo.1_Silent_p.T228T|PPP4R1_uc002kod.1_Silent_p.T365T|PPP4R1_uc010wzp.1_RNA	NM_001042388	NP_001035847	Q8TF05	PP4R1_HUMAN	protein phosphatase 4, regulatory subunit 1	382					protein phosphorylation|signal transduction	protein phosphatase 4 complex	protein binding|protein phosphatase type 4 regulator activity			skin(1)	1						GGTCTTCCATCGTGTTTTCCA	0.478													0	0	0	0.01441	0	161	79										T	9570582	C	T	9570582	2	4	116	1	0	0	0	0	0	0	0	1	12403	871	31	1		1	PPP4R1	18	9570582	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	4081468	9570582	68506666	298	34932										
AFG3L2	10939	broad.mit.edu	37	chr18	12367072	12367072	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccccagaacagagcagtccaGaggaagaacatcctgaaatc	9	12	0	5			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:12367072G>C	uc002kqz.1	-	5	557	c.444C>G	c.(442-444)CTC>CTG	p.L148L		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	148	Helical; (Potential).				cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	GAGCAGTCCAGAGGAAGAACA	0.453													0	0	0	0.013537	0	11	192										C	12367072	G	C	12367072	2	2	116	1	0	0	0	0	0	0	0	1	360	929	33	1		1	AFG3L2	18	12367072	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2796490	12367072	65710176	299	34933										
ANKRD30B	374860	broad.mit.edu	37	chr18	14764040	14764040	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttggaaaaaggaacatctaaTatgattgcatgtcctacaaa	7	6	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:14764040T>C	uc010dlo.2	+	7	1356	c.1176T>C	c.(1174-1176)AAT>AAC	p.N392N	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	392										ovary(1)|skin(1)	2						GAACATCTAATATGATTGCAT	0.383													0	0	0	0.004289	0	32	9										C	14764040	T	C	14764040	2	2	116	1	0	0	0	0	0	0	0	1	659	1403	49	5		5	ANKRD30B	18	14764040	Silent	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	2396968	14764040	63313208	300	34934										
ZNF521	25925	broad.mit.edu	37	chr18	22807046	22807046	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtagacacactggagggccGctcggtcctcatttggggag	15	10	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:22807046G>A	uc002kvk.2	-	4	1083	c.836C>T	c.(835-837)GCG>GTG	p.A279V	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.A279V|ZNF521_uc002kvl.2_Missense_Mutation_p.A59V	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	279					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CTGGAGGGCCGCTCGGTCCTC	0.557			T	PAX5	ALL								0	0	0	0.004672	0	3	55										A	22807046	G	A	22807046	3	1	116	1	0	0	0	0	1	0	0	0	17962	1087	38	2	3119	2	ZNF521	18	22807046	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	8043006	22807046	55270202	301	34935										
DSC3	1825	broad.mit.edu	37	chr18	28588292	28588292	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccttatagccgttgatctttGaccccactgctaagttttct	6	12	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:28588292G>A	uc002kwj.3	-	10	1618	c.1463C>T	c.(1462-1464)TCA>TTA	p.S488L	DSC3_uc002kwi.3_Missense_Mutation_p.S488L	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	488	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GTTGATCTTTGACCCCACTGC	0.403													0	0	0	0.001168	0	5	22										A	28588292	G	A	28588292	3	1	116	1	0	0	0	0	1	0	0	0	4767	1294	45	1	1286	1	DSC3	18	28588292	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	5781246	28588292	49488956	302	34936										
DSG4	147409	broad.mit.edu	37	chr18	28972175	28972175	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aactgatacgattacaagcaAttgatcttgatgaagaaggc	9	6	1	5			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:28972175A>G	uc002kwq.2	+	8	1012	c.877A>G	c.(877-879)ATT>GTT	p.I293V	DSG4_uc002kwr.2_Missense_Mutation_p.I293V	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	293	Cadherin 3.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATTACAAGCAATTGATCTTGA	0.343													0	0	0	0.008291	0	9	54										G	28972175	A	G	28972175	3	3	116	1	0	0	0	0	1	0	0	0	4779	101	4	5	907	5	DSG4	18	28972175	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	383883	28972175	49105073	303	34937										
MC4R	4160	broad.mit.edu	37	chr18	58038604	58038604	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttaatatctgctagacaagtCacaaaggcctcccaggggat	9	10	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:58038604C>T	uc002lie.1	-	1	1398	c.979G>A	c.(979-981)GAC>AAC	p.D327N		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	327	Cytoplasmic (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				CTAGACAAGTCACAAAGGCCT	0.418													0	0	0	0.01441	0	41	23										T	58038604	C	T	58038604	3	4	116	1	0	0	0	0	1	0	0	0	9366	826	29	1	23	1	MC4R	18	58038604	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	29066429	58038604	20038644	304	34938										
ATP9B	374868	broad.mit.edu	37	chr18	77089190	77089190	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggcctcacgctggtcagcaGggacctcacctccatgcagc	12	16	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr18:77089190G>C	uc002lmx.2	+	16	1837	c.1823G>C	c.(1822-1824)AGG>ACG	p.R608T	ATP9B_uc002lmv.1_RNA|ATP9B_uc002lmw.1_Missense_Mutation_p.R608T|ATP9B_uc002lmz.1_Missense_Mutation_p.R302T	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	608	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CTGGTCAGCAGGGACCTCACC	0.622													0	0	0	0.001168	0	6	16										C	77089190	G	C	77089190	3	2	116	1	0	0	0	0	1	0	0	0	1199	1000	35	4	1885	4	ATP9B	18	77089190	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	19050586	77089190	988058	305	34939										
PIAS4	51588	broad.mit.edu	37	chr19	4028756	4028756	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagcccggggtggagcccaaGaggccgtgccgccccatcaa	14	15	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:4028756G>C	uc002lzg.2	+	6	721	c.711G>C	c.(709-711)AAG>AAC	p.K237N		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	237	PINIT.				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGCCCAAGAGGCCGTGCC	0.647													0	0	0	0.006214	0	7	32										C	4028756	G	C	4028756	3	2	116	1	0	0	0	0	1	0	0	0	11878	933	33	1	733	1	PIAS4	19	4028756	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		4028756	55100227	306	34940										
PLIN4	729359	broad.mit.edu	37	chr19	4511893	4511893	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	actgtgtccttggtgccggtCagcacggtcttggccgtgtc	14	12	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:4511893C>G	uc002mar.1	-	3	2037	c.2037G>C	c.(2035-2037)CTG>CTC	p.L679L	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	679	18.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						TGGTGCCGGTCAGCACGGTCT	0.577													0	0	0	0.00245	0	11	252										G	4511893	C	G	4511893	2	3	116	1	0	0	0	0	0	0	0	1	12092	813	29	1		1	PLIN4	19	4511893	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	483137	4511893	54617090	307	34941										
UHRF1	29128	broad.mit.edu	37	chr19	4944248	4944248	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggcctcggccacatcgtcctCacagcgggactggggcaagg	15	14	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:4944248C>G	uc002mbo.2	+	8	1346	c.1178C>G	c.(1177-1179)TCA>TGA	p.S393*	UHRF1_uc010xik.1_RNA|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Nonsense_Mutation_p.S406*	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	393	Methyl-CpG binding and interaction with HDAC1.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		ACATCGTCCTCACAGCGGGAC	0.652													0	0	0	0.001168	0	4	39										G	4944248	C	G	4944248	4	3	116	1	0	0	0	0	0	1	0	0	16964	838	29	1	1243	1	UHRF1	19	4944248	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	432355	4944248	54184735	308	34942										
GPR108	56927	broad.mit.edu	37	chr19	6732095	6732095	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tccaccaggaacaaaatctcCttccacagcacgtagtcgct	6	15	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:6732095C>T	uc002mfp.2	-	13	1243	c.1197G>A	c.(1195-1197)AAG>AAA	p.K399K	GPR108_uc010duv.2_5'UTR|GPR108_uc002mfn.2_Silent_p.K70K|GPR108_uc002mfo.3_Silent_p.K157K|GPR108_uc010duw.2_RNA	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1	399						integral to membrane					0						ACAAAATCTCCTTCCACAGCA	0.652													0	0	0	0.001855	0	12	4										T	6732095	C	T	6732095	2	4	116	1	0	0	0	0	0	0	0	1	6624	680	24	2		2	GPR108	19	6732095	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1787847	6732095	52396888	309	34943										
ZNF823	55552	broad.mit.edu	37	chr19	11833886	11833886	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctttccggtggggggcctttCatgtgtctggaaggagtgct	16	8	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:11833886C>G	uc002msm.2	-	4	589	c.463G>C	c.(463-465)GAA>CAA	p.E155Q	ZNF823_uc010xmd.1_5'UTR|ZNF823_uc010dyi.1_Missense_Mutation_p.E111Q	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGGGGCCTTTCATGTGTCTGG	0.468										HNSCC(68;0.2)			0	0	0	0.001855	0	13	68										G	11833886	C	G	11833886	3	3	116	1	0	0	0	0	1	0	0	0	18176	835	29	1	1373	1	ZNF823	19	11833886	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5101791	11833886	47295097	310	34944										
ABHD8	79575	broad.mit.edu	37	chr19	17405223	17405223	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggccagtactggccgctcatCatggcccggagtacgaagga	14	12	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:17405223C>A	uc002ngb.3	-	4	1263	c.1023G>T	c.(1021-1023)ATG>ATT	p.M341I		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	341							hydrolase activity				0						GGCCGCTCATCATGGCCCGGA	0.632													1	0	8.34094e-07	0.008871	8.57619e-07	18	158										A	17405223	C	A	17405223	3	1	116	1	0	0	0	0	1	0	0	0	87	826	29	3	304	3	ABHD8	19	17405223	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	5571337	17405223	41723760	311	34945										
ZNF536	9745	broad.mit.edu	37	chr19	31039136	31039136	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctctcctctggagatcactcGgggcaggccacgggcatgtc	13	14	3	1	rs149881182	byFrequency	TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:31039136G>A	uc002nsu.1	+	4	2748	c.2610G>A	c.(2608-2610)TCG>TCA	p.S870S	ZNF536_uc010edd.1_Silent_p.S870S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GAGATCACTCGGGGCAGGCCA	0.582													0	0	0	0.009535	0	31	40										A	31039136	G	A	31039136	2	1	116	1	0	0	0	0	0	0	0	1	17971	1103	39	2		2	ZNF536	19	31039136	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	13633913	31039136	28089847	312	34946										
SARS2	54938	broad.mit.edu	37	chr19	39421292	39421292	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtgaaacttctccttggacTatcgttggagatgcagcctc	10	10	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:39421292T>C	uc002oka.2	-	1	245	c.85A>G	c.(85-87)AGT>GGT	p.S29G	SARS2_uc002ojz.2_5'Flank|SARS2_uc010xup.1_Missense_Mutation_p.S29G|SARS2_uc002okb.2_Missense_Mutation_p.S29G|SARS2_uc010xuq.1_Intron|SARS2_uc010xur.1_RNA|SARS2_uc010xus.1_Missense_Mutation_p.S29G|MRPS12_uc002okc.2_5'Flank|MRPS12_uc002okd.2_5'Flank|MRPS12_uc002oke.2_5'Flank	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	29					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTCCTTGGACTATCGTTGGAG	0.607											OREG0025455	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	88										C	39421292	T	C	39421292	3	2	116	1	0	0	0	0	1	0	0	0	13845	1522	53	5	1616	5	SARS2	19	39421292	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	8382156	39421292	19707691	313	34947										
AXL	558	broad.mit.edu	37	chr19	41737167	41737167	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtggcttggactccaggcctGagcggcatctaccccctgac	12	15	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:41737167G>C	uc010ehj.2	+	6	937	c.747G>C	c.(745-747)CTG>CTC	p.L249L	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Silent_p.L249L|AXL_uc010ehk.2_Silent_p.L249L	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	249	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						CTCCAGGCCTGAGCGGCATCT	0.622													0	0	0	0.001168	0	4	77										C	41737167	G	C	41737167	2	2	116	1	0	0	0	0	0	0	0	1	1238	1277	45	1		1	AXL	19	41737167	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2315875	41737167	17391816	314	34948										
ZNF221	7638	broad.mit.edu	37	chr19	44470975	44470975	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attcacgacgatcttcccatCagagatcccacaatggagaa	7	12	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:44470975C>G	uc002oxx.2	+	6	1649	c.1321C>G	c.(1321-1323)CAG>GAG	p.Q441E	ZNF221_uc010ejb.1_Missense_Mutation_p.Q441E|ZNF221_uc010xws.1_Missense_Mutation_p.Q441E	NM_013359	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	441	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Prostate(69;0.0352)				ATCTTCCCATCAGAGATCCCA	0.433													0	0	0	0.008291	0	9	87										G	44470975	C	G	44470975	3	3	116	1	0	0	0	0	1	0	0	0	17772	827	29	1	1335	1	ZNF221	19	44470975	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2733808	44470975	14658008	315	34949										
MARK4	57787	broad.mit.edu	37	chr19	45805792	45805792	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gccgccagccacagccgttcCtgctggcctgcctgcacggg	13	18	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:45805792C>T	uc002pbb.1	+	17	2088	c.2083C>T	c.(2083-2085)CTG>TTG	p.L695L	MARK4_uc002pba.1_3'UTR			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	695					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACAGCCGTTCCTGCTGGCCTG	0.726													0	0	0	0.001984	0	4	6										T	45805792	C	T	45805792	2	4	116	1	0	0	0	0	0	0	0	1	9315	696	24	2		2	MARK4	19	45805792	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	1334817	45805792	13323191	316	34950										
CD3EAP	10849	broad.mit.edu	37	chr19	45912513	45912513	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aagaagaagaagaagaaagaGagaggtcacacagtgactga	13	4	1	9			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:45912513G>C	uc002pbq.1	+	3	1775	c.1287G>C	c.(1285-1287)GAG>GAC	p.E429D	PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Missense_Mutation_p.E431D	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	429					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		agaagaaagagaGAGGTCACA	0.537													0	0	0	0.010504	0	22	10										C	45912513	G	C	45912513	3	2	116	1	0	0	0	0	1	0	0	0	3012	933	33	1	1297	1	CD3EAP	19	45912513	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	106721	45912513	13216470	317	34951										
QPCTL	54814	broad.mit.edu	37	chr19	46206179	46206179	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caggggtacccgtgctccatCtcatctccacgcccttccct	7	19	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:46206179C>G	uc010xxr.1	+	7	1242	c.1021C>G	c.(1021-1023)CTC>GTC	p.L341V	QPCTL_uc010ekn.2_Missense_Mutation_p.L247V	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	341					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		CGTGCTCCATCTCATCTCCAC	0.597													0	0	0	0.01441	0	86	125										G	46206179	C	G	46206179	3	3	116	1	0	0	0	0	1	0	0	0	12875	913	32	1	1047	1	QPCTL	19	46206179	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	293666	46206179	12922804	318	34952										
CARD8	22900	broad.mit.edu	37	chr19	48734962	48734962	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tcaactcaacatccacatttCcttcaggccccagaaactga	4	15	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:48734962C>T	uc002pie.3	-	4	495	c.182G>A	c.(181-183)GGA>GAA	p.G61E	CARD8_uc002pii.3_Missense_Mutation_p.G166E|CARD8_uc010xzi.1_Missense_Mutation_p.G61E|CARD8_uc010els.2_Missense_Mutation_p.G99E|CARD8_uc010xzj.1_Missense_Mutation_p.G166E|CARD8_uc010xzk.1_Missense_Mutation_p.G85E|CARD8_uc002pif.3_Missense_Mutation_p.G61E|CARD8_uc002pig.3_5'UTR|CARD8_uc002pih.3_Missense_Mutation_p.G116E|CARD8_uc010xzl.1_Missense_Mutation_p.G116E|CARD8_uc010xzm.1_Missense_Mutation_p.G166E	NM_014959	NP_055774	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	61					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity				0		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		ATCCACATTTCCTTCAGGCCC	0.363													0	0	0	0.01441	0	52	55										T	48734962	C	T	48734962	3	4	116	1	0	0	0	0	1	0	0	0	2651	855	30	1	1144	1	CARD8	19	48734962	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2528783	48734962	10394021	319	34953										
ZNF578	147660	broad.mit.edu	37	chr19	52994576	52994576	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attggtgtttatattttgtaGatatctcttccaaatgcatg	7	5	1	1	rs61191258		TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:52994576G>C	uc002pzp.3	+	3	124	c.-120_splice	c.e3-1			NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATATTTTGTAGATATCTCTTC	0.169													0	0	0	0.009096	0	3	2										C	52994576	G	C	52994576	5	2	116	1	0	0	0	0	0	0	1	0	18007	956	33	1		1	ZNF578	19	52994576	Splice_Site	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	4259614	52994576	6134407	320	34954										
FCAR	2204	broad.mit.edu	37	chr19	55401022	55401023	+	Missense_Mutation	DNP	CC	CC	TA													0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	attgtgtctccagactccatCcaccaagattacacgacgca							TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:55401022_55401023CC>TA	uc002qhr.1	+	5	854_855	c.657_658CC>TA	c.(655-660)ATCCAC>ATTAAC	p.H220N	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.H171N|FCAR_uc010esi.1_Missense_Mutation_p.H97N|FCAR_uc002qhu.1_Missense_Mutation_p.H124N|FCAR_uc002qhv.1_Missense_Mutation_p.H198N|FCAR_uc002qhw.1_Missense_Mutation_p.H208N|FCAR_uc002qhx.1_Missense_Mutation_p.H112N|FCAR_uc002qhy.1_Missense_Mutation_p.H186N|FCAR_uc002qhz.1_Nonsense_Mutation_p.P183*|FCAR_uc002qia.1_Missense_Mutation_p.H111N	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	220	Extracellular (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CAGACTCCATCCACCAAGATTA	0.515													0	0	0	0.004672	0	52	606										TA	55401023	CC	TA	55401022	3	4	116	1	0	0	0	0	1	0	0	0	5773	855	30	1	746	1	FCAR	19	55401022	Missense_Mutation	DNP	CC	TCGA-GV-A3JX-01A-11D-A20D-08	2406446	55401022	3727961	321	34955										
C19orf51	352909	broad.mit.edu	37	chr19	55677318	55677318	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagaagcagcacatctagctCggggttgctgtgcactgtat	12	10	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:55677318C>T	uc002qji.1	-	3	170	c.136G>A	c.(136-138)GAG>AAG	p.E46K	C19orf51_uc002qjj.1_Missense_Mutation_p.E93K|C19orf51_uc002qjk.1_5'UTR|C19orf51_uc002qjl.1_Missense_Mutation_p.E114K			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	46											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACATCTAGCTCGGGGTTGCTG	0.632											OREG0025679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	34	36										T	55677318	C	T	55677318	3	4	116	1	0	0	0	0	1	0	0	0	1933	893	31	1	1529	1	C19orf51	19	55677318	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	276296	55677318	3451665	322	34956										
ZNF667	63934	broad.mit.edu	37	chr19	56953734	56953734	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agaataagggttgttctttgAttgaagctttccccacattt	8	7	1	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:56953734A>T	uc002qnd.2	-	5	792	c.630T>A	c.(628-630)AAT>AAA	p.N210K	ZNF667_uc010etl.2_5'UTR|ZNF667_uc002qne.2_Missense_Mutation_p.N210K|ZNF667_uc010etm.2_Missense_Mutation_p.N153K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	210	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		TTGTTCTTTGATTGAAGCTTT	0.378													0	0	0	0.007413	0	17	152										T	56953734	A	T	56953734	3	4	116	1	0	0	0	0	1	0	0	0	18071	330	12	5	1206	5	ZNF667	19	56953734	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	1276416	56953734	2175249	323	34957										
SLC27A5	10998	broad.mit.edu	37	chr19	59011880	59011880	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caggtacccgcacactcactCggaggaggcagctcatcttg	11	14	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr19:59011880C>T	uc002qtc.2	-	5	1486	c.1376G>A	c.(1375-1377)CGA>CAA	p.R459Q	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	459	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CACACTCACTCGGAGGAGGCA	0.607													0	0	0	0.000602	0	4	31										T	59011880	C	T	59011880	3	4	116	1	0	0	0	0	1	0	0	0	14529	898	31	1	720	1	SLC27A5	19	59011880	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2058146	59011880	117103	324	34958										
ZCCHC3	85364	broad.mit.edu	37	chr20	279194	279194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggccttcttcctgggggccGagaggggctacagctggtac	17	11	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:279194G>A	uc002wdf.2	+	2	988	c.964G>A	c.(964-966)GAG>AAG	p.E322K	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	323							nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CCTGGGGGCCGAGAGGGGCTA	0.632													0	0	0	0.00874	0	43	64										A	279194	G	A	279194	3	1	116	1	0	0	0	0	1	0	0	0	17586	1059	37	1	969	1	ZCCHC3	20	279194	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		279194	62746326	325	34959										
ZCCHC3	85364	broad.mit.edu	37	chr20	279302	279302	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	acaggtgcttcaggtgcgggGaggaggggcacctgagccct	18	10	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:279302G>A	uc002wdf.2	+	2	1096	c.1072G>A	c.(1072-1074)GAG>AAG	p.E358K	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	359	CCHC-type 2.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CAGGTGCGGGGAGGAGGGGCA	0.607													0	0	0	0.01441	0	54	77										A	279302	G	A	279302	3	1	116	1	0	0	0	0	1	0	0	0	17586	1175	41	1	1077	1	ZCCHC3	20	279302	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	108	279302	62746218	326	34960										
CD93	22918	broad.mit.edu	37	chr20	23065965	23065965	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	atccagcagccggaatcctgGtcggcagccgcagaggaagg	15	12	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:23065965G>T	uc002wsv.2	-	1	1013	c.865C>A	c.(865-867)CCA>ACA	p.P289T		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	289	EGF-like 1.|Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGAATCCTGGTCGGCAGCCG	0.637													1	0	8.34094e-07	0.008871	8.57619e-07	18	258										T	23065965	G	T	23065965	3	4	116	1	0	0	0	0	1	0	0	0	3047	1261	44	4	1101	4	CD93	20	23065965	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	22786663	23065965	39959555	327	34961										
MYLK2	85366	broad.mit.edu	37	chr20	30412081	30412081	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtggcaagtttggggcagtcTgtacctgcatggagaaagcc	15	8	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:30412081T>A	uc002wwq.2	+	6	1000	c.898T>A	c.(898-900)TGT>AGT	p.C300S	MYLK2_uc002wws.2_5'Flank	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	300	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGGGGCAGTCTGTACCTGCAT	0.562													0	0	0	0.007291	0	23	41										A	30412081	T	A	30412081	3	1	116	1	0	0	0	0	1	0	0	0	10057	1580	55	5	916	5	MYLK2	20	30412081	Missense_Mutation	SNP	T	TCGA-GV-A3JX-01A-11D-A20D-08	7346116	30412081	32613439	328	34962										
EMILIN3	90187	broad.mit.edu	37	chr20	39990291	39990291	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agcctgaagcctggagccttGgctgctgacctgctcctgga	13	13	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:39990291G>C	uc002xjy.1	-	4	2142	c.1918C>G	c.(1918-1920)CAA>GAA	p.Q640E		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	640	Potential.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CTGGAGCCTTGGCTGCTGACC	0.632													0	0	0	0.009096	0	3	34										C	39990291	G	C	39990291	3	2	116	1	0	0	0	0	1	0	0	0	5095	1357	47	4	386	4	EMILIN3	20	39990291	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	9578210	39990291	23035229	329	34963										
LAMA5	3911	broad.mit.edu	37	chr20	60909254	60909254	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcgcccacctggacaggtgcCatctgcgcgtagcccctcca	11	18	1	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:60909254C>T	uc002ycq.2	-	22	2794	c.2727G>A	c.(2725-2727)ATG>ATA	p.M909I		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	909	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGACAGGTGCCATCTGCGCGT	0.672													0	0	0	0.007835	0	32	21										T	60909254	C	T	60909254	3	4	116	1	0	0	0	0	1	0	0	0	8609	594	21	2	8596	2	LAMA5	20	60909254	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	20918963	60909254	2116266	330	34964										
DIDO1	11083	broad.mit.edu	37	chr20	61512799	61512799	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gagaccccgacggcggccctCtgctgcctgagagcttcttc	12	16	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:61512799C>T	uc002ydr.1	-	16	4773	c.4509G>A	c.(4507-4509)CAG>CAA	p.Q1503Q	DIDO1_uc002yds.1_Silent_p.Q1503Q	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1503					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGGCGGCCCTCTGCTGCCTGA	0.587													0	0	0	0.01441	0	67	142										T	61512799	C	T	61512799	2	4	116	1	0	0	0	0	0	0	0	1	4522	912	32	1		1	DIDO1	20	61512799	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	603545	61512799	1512721	331	34965										
KCNQ2	3785	broad.mit.edu	37	chr20	62038153	62038153	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gcacaaggcgccacggccgcGtagcagctgttgagagcatc	14	13	0	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr20:62038153G>C	uc002yey.1	-	17	2640	c.2463C>G	c.(2461-2463)TAC>TAG	p.Y821*	KCNQ2_uc002yez.1_Nonsense_Mutation_p.Y790*|KCNQ2_uc002yfa.1_Nonsense_Mutation_p.Y803*|KCNQ2_uc002yfb.1_Nonsense_Mutation_p.Y793*	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	821	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCACGGCCGCGTAGCAGCTGT	0.642													0	0	0	0.010504	0	15	10										C	62038153	G	C	62038153	4	2	116	1	0	0	0	0	0	1	0	0	8083	1140	40	4	159	4	KCNQ2	20	62038153	Nonsense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	525354	62038153	987367	332	34966										
TPTE	7179	broad.mit.edu	37	chr21	10951278	10951278	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aaacttacctttctacaaatActcgaagaagaacatccatg	4	10	1	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr21:10951278A>G	uc002yip.1	-	10	802	c.434T>C	c.(433-435)GTA>GCA	p.V145A	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V127A|TPTE_uc002yir.1_Missense_Mutation_p.V107A|TPTE_uc010gkv.1_Missense_Mutation_p.V7A	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	145	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCTACAAATACTCGAAGAAG	0.244													0	0	0	0.001855	0	11	124										G	10951278	A	G	10951278	3	3	116	1	0	0	0	0	1	0	0	0	16427	391	14	5	1281	5	TPTE	21	10951278	Missense_Mutation	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08		10951278	37178617	333	34967										
UBASH3A	53347	broad.mit.edu	37	chr21	43838515	43838515	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttgcctcttttctagaccctGagagccctattccagtacaa	6	13	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr21:43838515G>A	uc002zbe.2	+	7	879	c.843G>A	c.(841-843)CTG>CTA	p.L281L	UBASH3A_uc002zbf.2_Silent_p.L243L|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.L243L	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	281	SH3.					cytosol|nucleus				ovary(3)	3						TCTAGACCCTGAGAGCCCTAT	0.522													0	0	0	0.013537	0	11	199										A	43838515	G	A	43838515	2	1	116	1	0	0	0	0	0	0	0	1	16836	1277	45	1		1	UBASH3A	21	43838515	Silent	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	32887237	43838515	4291380	334	34968										
UPB1	51733	broad.mit.edu	37	chr22	24906761	24906761	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gagagaagcttccttggacaGaatttgctgagtcagcagag	13	7	1	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:24906761G>C	uc003aaf.2	+	4	530	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	UPB1_uc003aae.2_Missense_Mutation_p.E69Q|UPB1_uc011ajt.1_Missense_Mutation_p.E137Q	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	137	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					TCCTTGGACAGAATTTGCTGA	0.502													0	0	0	0.014323	0	17	55										C	24906761	G	C	24906761	3	2	116	1	0	0	0	0	1	0	0	0	16999	943	33	1	423	1	UPB1	22	24906761	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08		24906761	26397805	335	34969										
SYN3	8224	broad.mit.edu	37	chr22	33402582	33402582	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tctgggcgttgcaggtccgtCatatagccattaggcaggtt	13	9	2	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:33402582C>T	uc003amx.2	-	1	225	c.66G>A	c.(64-66)ATG>ATA	p.M22I	SYN3_uc003amy.2_Missense_Mutation_p.M22I|SYN3_uc003amz.2_Missense_Mutation_p.M22I	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	22	A.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						GCAGGTCCGTCATATAGCCAT	0.607											OREG0003521	type=REGULATORY REGION|Gene=SYN3|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.01441	0	74	19										T	33402582	C	T	33402582	3	4	116	1	0	0	0	0	1	0	0	0	15439	826	29	1	1728	1	SYN3	22	33402582	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	8495821	33402582	17901984	336	34970										
MYH9	4627	broad.mit.edu	37	chr22	36695028	36695028	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ggcgaggctcttagatttctCctcctcttctgtgaggttgg	12	10	4	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36695028C>A	uc003apg.2	-	24	3268	c.3037G>T	c.(3037-3039)GAG>TAG	p.E1013*		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1013	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTAGATTTCTCCTCCTCTTCT	0.527			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				1	0	3.61183e-13	0.01441	3.84176e-13	44	14										A	36695028	C	A	36695028	4	1	116	1	0	0	0	0	0	1	0	0	10042	864	30	3	2917	3	MYH9	22	36695028	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3292446	36695028	14609538	337	34971			4	164		4	4	5156	C		3.319673e-05
MYH9	4627	broad.mit.edu	37	chr22	36695058	36695058	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	tgtgaggttggtggtgaactCagctattctgtcttccagca	12	8	3	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36695058C>T	uc003apg.2	-	24	3238	c.3007G>A	c.(3007-3009)GAG>AAG	p.E1003K		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1003	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GTGGTGAACTCAGCTATTCTG	0.498			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.01441	0	60	18										T	36695058	C	T	36695058	3	4	116	1	0	0	0	0	1	0	0	0	10042	835	29	1	2947	1	MYH9	22	36695058	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	30	36695058	14609508	338	34972			4	164		4	4	5156	C		3.319673e-05
MYH9	4627	broad.mit.edu	37	chr22	36697638	36697638	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccgcagccagctgcttctctCtgaccttcaccagctcctcc	6	20	3	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36697638C>G	uc003apg.2	-	21	2804	c.2573G>C	c.(2572-2574)AGA>ACA	p.R858T	MYH9_uc003aph.1_Missense_Mutation_p.R722T	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	858	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTGCTTCTCTCTGACCTTCAC	0.617			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated		OREG0026520	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	26	11										G	36697638	C	G	36697638	3	3	116	1	0	0	0	0	1	0	0	0	10042	913	32	1	3393	1	MYH9	22	36697638	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2580	36697638	14606928	339	34973			4	164		4	4	5156	C		3.319673e-05
MYH9	4627	broad.mit.edu	37	chr22	36700183	36700183	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	aatgcggtacagattgctgtCgagctccagggcttttatct	11	9	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:36700183C>G	uc003apg.2	-	19	2479	c.2248G>C	c.(2248-2250)GAC>CAC	p.D750H	MYH9_uc003aph.1_Missense_Mutation_p.D614H	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	750	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						AGATTGCTGTCGAGCTCCAGG	0.597			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.010771	0	34	7										G	36700183	C	G	36700183	3	3	116	1	0	0	0	0	1	0	0	0	10042	884	31	1	3726	1	MYH9	22	36700183	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	2545	36700183	14604383	340	34974			4	164		4	4	5156	C		3.319673e-05
GTPBP1	9567	broad.mit.edu	37	chr22	39104929	39104929	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaggatggacgagggatgcgGagagaccatatatgtcattg	16	5	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:39104929G>A	uc003awg.2	+	2	426	c.272G>A	c.(271-273)GGA>GAA	p.G91E		NM_004286	NP_004277	O00178	GTPB1_HUMAN	GTP binding protein 1	91					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			ovary(1)	1	Melanoma(58;0.04)					GAGGGATGCGGAGAGACCATA	0.393													0	0	0	0.01441	0	41	16										A	39104929	G	A	39104929	3	1	116	1	0	0	0	0	1	0	0	0	6878	1174	41	1	278	1	GTPBP1	22	39104929	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2404746	39104929	12199637	341	34975										
EP300	2033	broad.mit.edu	37	chr22	41568628	41568628	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ctggaacaggaggaagaagaGagaaaacgagaggaaaacac	14	5	0	4			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:41568628G>C	uc003azl.3	+	28	4973	c.4578G>C	c.(4576-4578)GAG>GAC	p.E1526D		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1526	Poly-Glu.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGGAAGAAGAGAGAAAACGAG	0.388			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.004482	0	7	26										C	41568628	G	C	41568628	3	2	116	1	0	0	0	0	1	0	0	0	5148	933	33	1	4688	1	EP300	22	41568628	Missense_Mutation	SNP	G	TCGA-GV-A3JX-01A-11D-A20D-08	2463699	41568628	9735938	342	34976										
CYP2D6	1565	broad.mit.edu	37	chr22	42523483	42523483	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agccctgtacttcgatgtcaCgggatgtcatatgggtcaca	11	10	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chr22:42523483C>T	uc003bce.2	-	7	1229	c.1139G>A	c.(1138-1140)CGT>CAT	p.R380H	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Missense_Mutation_p.R74H|CYP2D6_uc003bcf.2_Missense_Mutation_p.R329H	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	380							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						TTCGATGTCACGGGATGTCAT	0.612													0	0	0	0.009096	0	3	32										T	42523483	C	T	42523483	3	4	116	1	0	0	0	0	1	0	0	0	4169	536	19	2	366	2	CYP2D6	22	42523483	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	954855	42523483	8781083	343	34977										
SHROOM2	357	broad.mit.edu	37	chrX	9863321	9863321	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cttccagaacgacagccctcCtcaggtgagggggctcagca	12	14	2	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:9863321C>T	uc004csu.1	+	4	1463	c.1373C>T	c.(1372-1374)CCT>CTT	p.P458L		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	458					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				GACAGCCCTCCTCAGGTGAGG	0.677													0	0	0	0.001984	0	6	26										T	9863321	C	T	9863321	3	4	116	1	0	0	0	0	1	0	0	0	14294	681	24	2	1387	2	SHROOM2	23	9863321	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08		9863321	145407239	344	34978										
MID1	4281	broad.mit.edu	37	chrX	10427830	10427830	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gggtactatcatccagctatCagccgaattacacagacctg	8	12	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:10427830C>G	uc004cte.3	-	8	1494	c.1303G>C	c.(1303-1305)GAT>CAT	p.D435H	MID1_uc004ctd.3_Missense_Mutation_p.D146H|MID1_uc004ctg.3_Missense_Mutation_p.D435H|MID1_uc004cth.3_Missense_Mutation_p.D397H|MID1_uc004ctk.3_Missense_Mutation_p.D435H|MID1_uc004cti.3_Missense_Mutation_p.D435H|MID1_uc004ctj.3_Missense_Mutation_p.D435H|MID1_uc011mie.1_RNA|MID1_uc004csz.3_Missense_Mutation_p.D107H|MID1_uc004cta.3_Missense_Mutation_p.D191H|MID1_uc004ctb.3_Missense_Mutation_p.D95H|MID1_uc004ctc.3_Missense_Mutation_p.D202H	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	435	Fibronectin type-III.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						ATCCAGCTATCAGCCGAATTA	0.463													0	0	0	0.013537	0	9	144										G	10427830	C	G	10427830	3	3	116	1	0	0	0	0	1	0	0	0	9576	826	29	1	712	1	MID1	23	10427830	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	564509	10427830	144842730	345	34979										
FAM47C	442444	broad.mit.edu	37	chrX	37027200	37027200	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agtctccacctggagcctccAgagactggagtgtcccatct	10	14	2	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637													0	0	0	0.004672	0	3	71										C	37027200	A	C	37027200	2	2	116	1	0	0	0	0	0	0	0	1	5571	175	7	5		5	FAM47C	23	37027200	Silent	SNP	A	TCGA-GV-A3JX-01A-11D-A20D-08	26599370	37027200	118243360	346	34980										
HUWE1	10075	broad.mit.edu	37	chrX	53617425	53617425	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ccagagacatagcaattgctCtcatcatctggtcctcttca	6	13	5	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:53617425C>G	uc004dsp.2	-	35	4532	c.4130G>C	c.(4129-4131)AGA>ACA	p.R1377T	HUWE1_uc004dsn.2_Missense_Mutation_p.R202T	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1377	UIM.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGCAATTGCTCTCATCATCTG	0.443													0	0	0	0.01441	0	103	9										G	53617425	C	G	53617425	3	3	116	1	0	0	0	0	1	0	0	0	7461	913	32	1	9194	1	HUWE1	23	53617425	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	16590225	53617425	101653135	347	34981										
OTUD6A	139562	broad.mit.edu	37	chrX	69282408	69282408	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	agagtgaacagcagcgcataCtgcgccgccaccaacgcgag	12	14	0	2			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:69282408C>G	uc004dxu.1	+	1	68	c.34C>G	c.(34-36)CTG>GTG	p.L12V		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	12										lung(1)|skin(1)	2						GCAGCGCATACTGCGCCGCCA	0.532													0	0	0	0.004672	0	3	10										G	69282408	C	G	69282408	3	3	116	1	0	0	0	0	1	0	0	0	11316	564	20	4	36	4	OTUD6A	23	69282408	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	15664983	69282408	85988152	348	34982										
BRWD3	254065	broad.mit.edu	37	chrX	79936980	79936980	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	caagtagatatagtgaaagcCcttcagcagcatctgaaact	8	9	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:79936980C>G	uc004edt.2	-	40	4777	c.4514G>C	c.(4513-4515)GGG>GCG	p.G1505A	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G1101A|BRWD3_uc004edp.2_Missense_Mutation_p.G1334A|BRWD3_uc004edq.2_Missense_Mutation_p.G1101A|BRWD3_uc010nmj.1_Missense_Mutation_p.G1101A|BRWD3_uc004edr.2_Missense_Mutation_p.G1175A|BRWD3_uc004eds.2_Missense_Mutation_p.G1101A|BRWD3_uc004edu.2_Missense_Mutation_p.G1175A|BRWD3_uc004edv.2_Missense_Mutation_p.G1101A|BRWD3_uc004edw.2_Missense_Mutation_p.G1101A|BRWD3_uc004edx.2_Missense_Mutation_p.G1101A|BRWD3_uc004edy.2_Missense_Mutation_p.G1101A|BRWD3_uc004edz.2_Missense_Mutation_p.G1175A|BRWD3_uc004eea.2_Missense_Mutation_p.G1175A|BRWD3_uc004eeb.2_Missense_Mutation_p.G1101A	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1505										ovary(4)	4						TAGTGAAAGCCCTTCAGCAGC	0.373													0	0	0	0.000602	0	5	33										G	79936980	C	G	79936980	3	3	116	1	0	0	0	0	1	0	0	0	1526	623	22	4	902	4	BRWD3	23	79936980	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	10654572	79936980	75333580	349	34983										
PCDH19	57526	broad.mit.edu	37	chrX	99663097	99663097	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagctcgttgggcgtgagctCgtaagtctgcacgccaaagc	13	12	1	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:99663097C>G	uc010nmz.2	-	1	2175	c.499G>C	c.(499-501)GAG>CAG	p.E167Q	PCDH19_uc004efw.3_Missense_Mutation_p.E167Q|PCDH19_uc004efx.3_Missense_Mutation_p.E167Q	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	167	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GGCGTGAGCTCGTAAGTCTGC	0.637													0	0	0	0.005524	0	39	5										G	99663097	C	G	99663097	3	3	116	1	0	0	0	0	1	0	0	0	11514	893	31	1	2971	1	PCDH19	23	99663097	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	19726117	99663097	55607463	350	34984										
MORC4	79710	broad.mit.edu	37	chrX	106243186	106243186	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	cagggccggcgggggcccctCggtacaggagcatttttttg	16	11	0	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:106243186C>T	uc004emu.3	-	1	257	c.14G>A	c.(13-15)CGA>CAA	p.R5Q	MORC4_uc004emv.3_Missense_Mutation_p.R5Q|MORC4_uc004emw.3_5'UTR	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	5							ATP binding|zinc ion binding			ovary(1)	1						gggggccccTCGGTACAGGAG	0.448													0	0	0	0.00308	0	6	0										T	106243186	C	T	106243186	3	4	116	1	0	0	0	0	1	0	0	0	9704	884	31	1	2867	1	MORC4	23	106243186	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	6580089	106243186	49027374	351	34985										
BCORL1	63035	broad.mit.edu	37	chrX	129149373	129149373	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttttctggtgtgccatctctCagctccagcgaagccgtgca	10	13	3	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:129149373C>G	uc004evb.1	+	4	2739	c.2625C>G	c.(2623-2625)CTC>CTG	p.L875L	BCORL1_uc010nrd.1_Silent_p.L777L	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	875					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGCCATCTCTCAGCTCCAGCG	0.602													0	0	0	0.000602	0	5	30										G	129149373	C	G	129149373	2	3	116	1	0	0	0	0	0	0	0	1	1387	813	29	1		1	BCORL1	23	129149373	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	22906187	129149373	26121187	352	34986										
BCORL1	63035	broad.mit.edu	37	chrX	129149590	129149590	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtggggacattcgaatgaatCaggggcctgaggaatcagag	16	6	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:129149590C>T	uc004evb.1	+	4	2956	c.2842C>T	c.(2842-2844)CAG>TAG	p.Q948*	BCORL1_uc010nrd.1_Nonsense_Mutation_p.Q850*	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	948					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TCGAATGAATCAGGGGCCTGA	0.567													0	0	0	0.006214	0	8	49										T	129149590	C	T	129149590	4	4	116	1	0	0	0	0	0	1	0	0	1387	827	29	1	2852	1	BCORL1	23	129149590	Nonsense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	217	129149590	26120970	353	34987										
ENOX2	10495	broad.mit.edu	37	chrX	129790591	129790591	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	ttttgtttctgtcatttcttCtatttcatcatcagacattt	3	8	7	1			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:129790591C>G	uc004evw.2	-	11	1598	c.1180G>C	c.(1180-1182)GAA>CAA	p.E394Q	ENOX2_uc004evx.2_Missense_Mutation_p.E365Q|ENOX2_uc004evy.2_Missense_Mutation_p.E365Q|ENOX2_uc004evv.2_Missense_Mutation_p.E221Q	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	394	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GTCATTTCTTCTATTTCATCA	0.269													0	0	0	0.01441	0	46	4										G	129790591	C	G	129790591	3	3	116	1	0	0	0	0	1	0	0	0	5127	922	32	1	676	1	ENOX2	23	129790591	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	641001	129790591	25479969	354	34988										
CNGA2	1260	broad.mit.edu	37	chrX	150911830	150911830	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gtcctctacatcttggtcatCatccactggaatgcctgcat	7	13	4	0			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:150911830C>A	uc004fey.1	+	7	1079	c.855C>A	c.(853-855)ATC>ATA	p.I285I		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	285	Helical; Name=H4; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGGTCATCATCCACTGGA	0.493													1	0	3.13773e-49	0.01441	3.40063e-49	111	22										A	150911830	C	A	150911830	2	1	116	1	0	0	0	0	0	0	0	1	3597	816	29	3		3	CNGA2	23	150911830	Silent	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	21121239	150911830	4358730	355	34989										
F8	2157	broad.mit.edu	37	chrX	154227805	154227805	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.497191011235955	177	5.93606753184626e-61	3.7512464591735	5.06948109058927	2.7372198196229	0.00204234626314866	0.00948232193604735	130	gaaaaggtgatccgtgaattCtacaaacagagtctttttgt	9	6	2	3			TCGA-GV-A3JX-01A-11D-A20D-08	TCGA-GV-A3JX-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21525d6f-4222-4e0a-9f07-8adbbd55c54f	aecc0cdf-ce83-4121-a26b-b31d1d86ec2f	g.chrX:154227805C>G	uc004fmt.2	-	2	385	c.214G>C	c.(214-216)GAA>CAA	p.E72Q	F8_uc011mzx.1_Missense_Mutation_p.E37Q	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	72	Plastocyanin-like 1.|F5/8 type A 1.		E -> K (in HEMA; moderate).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCCGTGAATTCTACAAACAGA	0.388													0	0	0	0.007291	0	23	91										G	154227805	C	G	154227805	3	3	116	1	0	0	0	0	1	0	0	0	5350	922	32	1	6969	1	F8	23	154227805	Missense_Mutation	SNP	C	TCGA-GV-A3JX-01A-11D-A20D-08	3315975	154227805	1042755	356	34990										
TAS1R3	83756	broad.mit.edu	37	chr1	1268136	1268136	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggccctgcacaacactcttCagtgcaacgcctcaggctgc	9	16	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:1268136C>T	uc010nyk.1	+	3	1225	c.1225C>T	c.(1225-1227)CAG>TAG	p.Q409*		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	409	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CAACACTCTTCAGTGCAACGC	0.637													0	0	0	0.006122	0	15	51										T	1268136	C	T	1268136	4	4	117	1	0	0	0	0	0	1	0	0	15561	827	29	1	1235	1	TAS1R3	1	1268136	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		1268136	247982485	1	34991										
C1orf86	199990	broad.mit.edu	37	chr1	2125221	2125221	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctggcgggggattccaggtgCcctcctgccccgtgaagcag	15	14	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:2125221C>T	uc001aiy.2	-	3	353	c.327G>A	c.(325-327)GGG>GGA	p.G109G	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Missense_Mutation_p.G105D	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	109											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		ATTCCAGGTGCCCTCCTGCCC	0.701													0	0	0	0.003163	0	16	28										T	2125221	C	T	2125221	2	4	117	1	0	0	0	0	0	0	0	1	2063	739	26	2		2	C1orf86	1	2125221	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	857085	2125221	247125400	2	34992										
MMEL1	79258	broad.mit.edu	37	chr1	2526322	2526322	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctcaaagtacaggtcctctGagaagttcagctacgggaga	11	9	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:2526322G>A	uc001ajy.2	-	17	1809	c.1595C>T	c.(1594-1596)TCA>TTA	p.S532L	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	532	Potential.|Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGGTCCTCTGAGAAGTTCAG	0.607													0	0	0	0.00361	0	47	41										A	2526322	G	A	2526322	3	1	117	1	0	0	0	0	1	0	0	0	9646	1294	45	1	776	1	MMEL1	1	2526322	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	401101	2526322	246724299	3	34993										
PER3	8863	broad.mit.edu	37	chr1	7902801	7902801	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctgtggtcaggttctggtaGaagacagctgttgagtgact	14	7	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:7902801G>C	uc001aoo.2	+	21	3767	c.3592G>C	c.(3592-3594)GAA>CAA	p.E1198Q	PER3_uc001aop.2_Missense_Mutation_p.E1207Q|PER3_uc010nzw.1_Missense_Mutation_p.E887Q	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1198	CRY binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GGTTCTGGTAGAAGACAGCTG	0.453													0	0	0	0.00278	0	20	55										C	7902801	G	C	7902801	3	2	117	1	0	0	0	0	1	0	0	0	11731	943	33	1	3674	1	PER3	1	7902801	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5376479	7902801	241347820	4	34994										
DFFA	1676	broad.mit.edu	37	chr1	10529339	10529339	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atccactatggtgccatcctCtgccaggaccagggtgactg	11	13	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:10529339C>G	uc001arj.2	-	2	291	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	DFFA_uc001ark.2_Missense_Mutation_p.E65Q	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	65	CIDE-N.				DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		GTGCCATCCTCTGCCAGGACC	0.428													0	0	0	0.007291	0	26	61										G	10529339	C	G	10529339	3	3	117	1	0	0	0	0	1	0	0	0	4452	922	32	1	846	1	DFFA	1	10529339	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2626538	10529339	238721282	5	34995										
EXOSC10	5394	broad.mit.edu	37	chr1	11132177	11132177	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgccttcttcttgacagcttCtttagagtctttttgtactt	6	9	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:11132177C>A	uc001asa.2	-	20	2259	c.2209G>T	c.(2209-2211)GAA>TAA	p.E737*	EXOSC10_uc001asb.2_Nonsense_Mutation_p.E712*	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	737					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TTGACAGCTTCTTTAGAGTCT	0.453													1	0	5.78141e-17	0.013114	6.17496e-17	34	70										A	11132177	C	A	11132177	4	1	117	1	0	0	0	0	0	1	0	0	5314	922	32	3	472	3	EXOSC10	1	11132177	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	602838	11132177	238118444	6	34996										
PLOD1	5351	broad.mit.edu	37	chr1	12020784	12020784	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgtgaagctggtgggccctGaggtgcggatggcgaatgca	18	8	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:12020784G>A	uc001atm.2	+	10	1148	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	PLOD1_uc010obb.1_Missense_Mutation_p.E400K	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	353					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGTGGGCCCTGAGGTGCGGAT	0.627													0	0	0	0.00361	0	58	39										A	12020784	G	A	12020784	3	1	117	1	0	0	0	0	1	0	0	0	12101	1291	45	1	1095	1	PLOD1	1	12020784	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	888607	12020784	237229837	7	34997										
ATP13A2	23400	broad.mit.edu	37	chr1	17323611	17323611	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtgtgccgccggtgtgtctCtgcacagtagggccccagcc	14	14	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:17323611C>T	uc001baa.2	-	12	1289	c.1099G>A	c.(1099-1101)GAG>AAG	p.E367K	ATP13A2_uc001bab.2_Missense_Mutation_p.E362K|ATP13A2_uc001bac.2_Missense_Mutation_p.E362K|ATP13A2_uc009vpa.1_Missense_Mutation_p.E80K|ATP13A2_uc001bad.1_Missense_Mutation_p.E80K	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	367	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CGGTGTGTCTCTGCACAGTAG	0.652													0	0	0	0.00361	0	130	68										T	17323611	C	T	17323611	3	4	117	1	0	0	0	0	1	0	0	0	1124	922	32	1	2751	1	ATP13A2	1	17323611	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5302827	17323611	231927010	8	34998										
UBR4	23352	broad.mit.edu	37	chr1	19497282	19497282	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tatttgccttgcacctgctaGagccaatagccaaaacagca	7	12	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:19497282G>C	uc001bbi.2	-	26	3621	c.3617C>G	c.(3616-3618)TCT>TGT	p.S1206C	UBR4_uc001bbm.1_Missense_Mutation_p.S417C	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1206					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCACCTGCTAGAGCCAATAGC	0.428													0	0	0	0.00361	0	71	37										C	19497282	G	C	19497282	3	2	117	1	0	0	0	0	1	0	0	0	16901	942	33	1	12258	1	UBR4	1	19497282	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2173671	19497282	229753339	9	34999										
MYOM3	127294	broad.mit.edu	37	chr1	24387794	24387794	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgttcagccattgcatcctCaaaagctataagaaggacag	9	9	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:24387794C>T	uc001bin.3	-	34	4103	c.3940G>A	c.(3940-3942)GAG>AAG	p.E1314K	MYOM3_uc001bil.3_Missense_Mutation_p.E207K|MYOM3_uc001bim.3_Missense_Mutation_p.E971K	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1314										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ATTGCATCCTCAAAAGCTATA	0.502													0	0	0	0.001368	0	10	27										T	24387794	C	T	24387794	3	4	117	1	0	0	0	0	1	0	0	0	10093	835	29	1	389	1	MYOM3	1	24387794	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4890512	24387794	224862827	10	35000										
RHD	6007	broad.mit.edu	37	chr1	25599110	25599110	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctaacactggaagcagctctCattctcctcttctatttttt	4	12	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:25599110C>T	uc001bjz.2	+	1	130	c.72C>T	c.(70-72)CTC>CTT	p.L24L	RHD_uc010oep.1_Silent_p.L24L|RHD_uc001bkc.2_Silent_p.L24L|RHD_uc009vrm.2_5'UTR|RHD_uc001bka.2_Silent_p.L24L|RHD_uc001bkb.2_Silent_p.L24L|RHD_uc009vrn.2_Silent_p.L24L|RHD_uc009vro.2_Silent_p.L24L|RHD_uc009vrp.2_Silent_p.L24L	NM_016124	NP_057208	Q02161	RHD_HUMAN	Rh blood group D antigen isoform 1	24	Helical; (Potential).					integral to plasma membrane				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		AAGCAGCTCTCATTCTCCTCT	0.532													0	0	0	0.010729	0	9	45										T	25599110	C	T	25599110	2	4	117	1	0	0	0	0	0	0	0	1	13327	813	29	1		1	RHD	1	25599110	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1211316	25599110	223651511	11	35001										
SF3A3	10946	broad.mit.edu	37	chr1	38450421	38450421	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctctcgagccttcaggagttCctcaaattccactgacattg	7	13	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:38450421C>T	uc001cci.2	-	5	458	c.334G>A	c.(334-336)GAA>AAA	p.E112K	SF3A3_uc010oik.1_Missense_Mutation_p.E59K	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3	112					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TTCAGGAGTTCCTCAAATTCC	0.353													0	0	0	0.013114	0	35	86										T	38450421	C	T	38450421	3	4	117	1	0	0	0	0	1	0	0	0	14148	864	30	1	1223	1	SF3A3	1	38450421	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	12851311	38450421	210800200	12	35002										
MACF1	23499	broad.mit.edu	37	chr1	39782127	39782127	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aactcttggtcaaaggttatGagattaagctgagtcaagaa	10	5	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:39782127G>C	uc010ois.1	+	29	3734	c.3529G>C	c.(3529-3531)GAG>CAG	p.E1177Q	MACF1_uc001cda.1_Missense_Mutation_p.E1085Q|MACF1_uc001cdc.1_Missense_Mutation_p.E264Q|MACF1_uc009vvq.1_Missense_Mutation_p.E234Q|MACF1_uc001cdb.1_Missense_Mutation_p.E264Q	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1177					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAAAGGTTATGAGATTAAGCT	0.433													0	0	0	0.00361	0	82	50										C	39782127	G	C	39782127	3	2	117	1	0	0	0	0	1	0	0	0	9144	1291	45	1	3635	1	MACF1	1	39782127	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1331706	39782127	209468494	13	35003										
EBNA1BP2	10969	broad.mit.edu	37	chr1	43637293	43637293	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acccattccagatcccgcttGaattctgccaaacattgctt	5	14	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:43637293G>A	uc001cin.2	-	3	377	c.180C>T	c.(178-180)TTC>TTT	p.F60F	EBNA1BP2_uc001cio.2_Silent_p.F115F|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_5'UTR|EBNA1BP2_uc010ojx.1_Silent_p.F115F|EBNA1BP2_uc010ojy.1_RNA	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	60					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATCCCGCTTGAATTCTGCCA	0.522													0	0	0	0.00361	0	146	109										A	43637293	G	A	43637293	2	1	117	1	0	0	0	0	0	0	0	1	4885	1281	45	1		1	EBNA1BP2	1	43637293	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3855166	43637293	205613328	14	35004										
BEND5	79656	broad.mit.edu	37	chr1	49208411	49208411	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cggctcgggctcgagacattCtgactttactttttccagat	9	11	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:49208411C>T	uc001crx.3	-	4	822	c.778G>A	c.(778-780)GAA>AAA	p.E260K	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Missense_Mutation_p.E91K	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	260										skin(1)	1						TCGAGACATTCTGACTTTACT	0.443													0	0	0	0.000602	0	3	76										T	49208411	C	T	49208411	3	4	117	1	0	0	0	0	1	0	0	0	1401	922	32	1	499	1	BEND5	1	49208411	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5571118	49208411	200042210	15	35005										
EPS15	2060	broad.mit.edu	37	chr1	51913720	51913720	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agagcctgatatactgaccgTttttctcttagatggtggca	10	8	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:51913720T>A	uc001csq.1	-	9	741	c.649A>T	c.(649-651)ACG>TCG	p.T217S	EPS15_uc009vyz.1_Missense_Mutation_p.T217S	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	217					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						ATACTGACCGTTTTTCTCTTA	0.463			T	MLL	ALL								0	0	0	0.002299	0	19	59										A	51913720	T	A	51913720	3	1	117	1	0	0	0	0	1	0	0	0	5192	1725	60	5	2207	5	EPS15	1	51913720	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	2705309	51913720	197336901	16	35006										
GADD45A	1647	broad.mit.edu	37	chr1	68152235	68152235	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccgcggcgagcgagggcgccGagcagcccccggacctgcac	16	18	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:68152235G>A	uc001ddz.1	+	3	644	c.349G>A	c.(349-351)GAG>AAG	p.E117K	GADD45A_uc009wbb.1_Missense_Mutation_p.E83K|GADD45A_uc009wbc.1_Intron|GADD45A_uc009wbd.1_Intron	NM_001924	NP_001915	P24522	GA45A_HUMAN	growth arrest and DNA-damage-inducible, alpha	117					apoptosis|cell cycle arrest|cellular response to ionizing radiation|cellular response to mechanical stimulus|DNA repair|positive regulation of reactive oxygen species metabolic process|regulation of cyclin-dependent protein kinase activity|signal transduction in response to DNA damage	nucleus	protein binding			ovary(1)	1						CGAGGGCGCCGAGCAGCCCCC	0.706													0	0	0	0.00632	0	19	9										A	68152235	G	A	68152235	3	1	117	1	0	0	0	0	1	0	0	0	6181	1059	37	1	359	1	GADD45A	1	68152235	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	16238515	68152235	181098386	17	35007										
CTH	1491	broad.mit.edu	37	chr1	70897772	70897772	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgttcattttgcagctcttgGagcagttccatctcctattg	8	10	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:70897772G>T	uc001dfd.2	+	8	875	c.731G>T	c.(730-732)GGA>GTA	p.G244V	CTH_uc009wbl.1_RNA|CTH_uc001dfe.2_Missense_Mutation_p.G200V|CTH_uc010oqq.1_Missense_Mutation_p.G212V	NM_001902	NP_001893	P32929	CGL_HUMAN	cystathionase isoform 1	244					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GCAGCTCTTGGAGCAGTTCCA	0.438													1	0	1.02788e-11	0.00499	1.07691e-11	14	35										T	70897772	G	T	70897772	3	4	117	1	0	0	0	0	1	0	0	0	4009	1174	41	3	761	3	CTH	1	70897772	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2745537	70897772	178352849	18	35008										
C1orf173	127254	broad.mit.edu	37	chr1	75037069	75037069	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttgctcctgtcctagccctGaggtcttccgctccagggct	10	16	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:75037069G>C	uc001dgg.2	-	14	4544	c.4325C>G	c.(4324-4326)TCA>TGA	p.S1442*		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1442	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCCTAGCCCTGAGGTCTTCCG	0.612													0	0	0	0.00361	0	58	159										C	75037069	G	C	75037069	4	2	117	1	0	0	0	0	0	1	0	0	2014	1294	45	1	271	1	C1orf173	1	75037069	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4139297	75037069	174213552	19	35009										
BARHL2	343472	broad.mit.edu	37	chr1	91182377	91182377	+	Frame_Shift_Del	DEL	G	G	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcggccgagcccagctgctGggggggcggcggcggcggct							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:91182377delG	uc001dns.2	-	1	418	c.376delC	c.(376-378)CAGfs	p.Q126fs		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	126	Gln/Pro-rich.					nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CCCAGCTGCTGGGGGggcggc	0.423																		2	4	---	---								-	91182377	G	-	91182377	7	5	117	1	0	1	0	1	0	0	0	0	1314	1357	47	0	799	0	BARHL2	1	91182377	Frame_Shift_Del	DEL	G	TCGA-GV-A3JZ-01A-11D-A21A-08	16145308	91182377	158068244	20	35010										
MAGI3	260425	broad.mit.edu	37	chr1	114128143	114128143	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgacatctgtcagcaagatgGaaagaatggatagctctctt	10	8	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:114128143G>A	uc001edk.2	+	4	869	c.688G>A	c.(688-690)GAA>AAA	p.E230K	MAGI3_uc001edh.3_Missense_Mutation_p.E230K|MAGI3_uc001edi.3_Missense_Mutation_p.E230K|MAGI3_uc010owm.1_Missense_Mutation_p.E230K	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	230	Guanylate kinase-like.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGCAAGATGGAAAGAATGGA	0.418													0	0	0	0.006122	0	17	34										A	114128143	G	A	114128143	3	1	117	1	0	0	0	0	1	0	0	0	9192	1175	41	1	702	1	MAGI3	1	114128143	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	22945766	114128143	135122478	21	35011										
DENND2C	163259	broad.mit.edu	37	chr1	115147614	115147614	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tttggaataactttaagtctCtcttccatgtctttggactg	7	8	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:115147614C>T	uc001efd.1	-	11	2298	c.1596G>A	c.(1594-1596)GAG>GAA	p.E532E	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Silent_p.E475E	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	532	UDENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTTAAGTCTCTCTTCCATGT	0.343													0	0	0	0.001368	0	12	12										T	115147614	C	T	115147614	2	4	117	1	0	0	0	0	0	0	0	1	4430	912	32	1		1	DENND2C	1	115147614	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1019471	115147614	134103007	22	35012										
DENND2C	163259	broad.mit.edu	37	chr1	115147649	115147649	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggactgcttatagccatgatCatcctgaaaaagataacacc	7	10	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:115147649C>T	uc001efd.1	-	11	2263	c.1561G>A	c.(1561-1563)GAT>AAT	p.D521N	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.D464N	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	521	UDENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGCCATGATCATCCTGAAAA	0.363													0	0	0	0.001168	0	6	8										T	115147649	C	T	115147649	3	4	117	1	0	0	0	0	1	0	0	0	4430	826	29	1	1269	1	DENND2C	1	115147649	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	35	115147649	134102972	23	35013										
SPAG17	200162	broad.mit.edu	37	chr1	118624183	118624183	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccagaaggtttcagtttcccTttttcatcaacctcagagag	7	11	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:118624183T>C	uc001ehk.2	-	14	1913	c.1845A>G	c.(1843-1845)AAA>AAG	p.K615K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	615						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCAGTTTCCCTTTTTCATCAA	0.448													0	0	0	0.009096	0	3	87										C	118624183	T	C	118624183	2	2	117	1	0	0	0	0	0	0	0	1	14979	1606	56	5		5	SPAG17	1	118624183	Silent	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	3476534	118624183	130626438	24	35014										
SPAG17	200162	broad.mit.edu	37	chr1	118640379	118640379	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacatcaaagagatttgtttCaggtttctcattattcagga	7	6	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:118640379C>T	uc001ehk.2	-	7	993	c.925G>A	c.(925-927)GAA>AAA	p.E309K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	309						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AGATTTGTTTCAGGTTTCTCA	0.373													0	0	0	0.001855	0	13	31										T	118640379	C	T	118640379	3	4	117	1	0	0	0	0	1	0	0	0	14979	835	29	1	5914	1	SPAG17	1	118640379	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	16196	118640379	130610242	25	35015										
PDE4DIP	9659	broad.mit.edu	37	chr1	144857625	144857625	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tatttaccatttgctctgttGattatgggcgtttctgagcc	9	8	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144857625G>A	uc001elw.3	-	39	6720	c.6429C>T	c.(6427-6429)ATC>ATT	p.I2143I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.I2037I|PDE4DIP_uc001elv.3_Silent_p.I1150I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2143					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTGCTCTGTTGATTATGGGCG	0.468			T	PDGFRB	MPD								0	0	0	0.013114	0	35	289										A	144857625	G	A	144857625	2	1	117	1	0	0	0	0	0	0	0	1	11643	1280	45	1		1	PDE4DIP	1	144857625	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	26217246	144857625	104392996	26	35016										
PDE4DIP	9659	broad.mit.edu	37	chr1	144871718	144871718	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctcccaactgcttctgcagCatctgtagctcctgctgagc	8	15	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144871718C>A	uc001elw.3	-	32	5535	c.5244G>T	c.(5242-5244)ATG>ATT	p.M1748I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.M755I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1748	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTTCTGCAGCATCTGTAGCT	0.582			T	PDGFRB	MPD								1	0	0.00229938	0.002299	0.00233481	10	184										A	144871718	C	A	144871718	3	1	117	1	0	0	0	0	1	0	0	0	11643	710	25	4	1848	4	PDE4DIP	1	144871718	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	14093	144871718	104378903	27	35017										
PDE4DIP	9659	broad.mit.edu	37	chr1	144882662	144882662	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctcagcacaagttgttctttGaggaggttgatgatattgtg	12	5	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:144882662G>C	uc001elw.3	-	24	3648	c.3357C>G	c.(3355-3357)CTC>CTG	p.L1119L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Silent_p.L126L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1119	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTTGTTCTTTGAGGAGGTTGA	0.453			T	PDGFRB	MPD								0	0	0	0.005443	0	24	186										C	144882662	G	C	144882662	2	2	117	1	0	0	0	0	0	0	0	1	11643	1277	45	1		1	PDE4DIP	1	144882662	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	10944	144882662	104367959	28	35018										
GABPB2	126626	broad.mit.edu	37	chr1	151065682	151065682	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgacagaatggtgcagatgtGaatgccaaggacatgctgaa	13	6	0	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:151065682G>T	uc001ewr.2	+	4	622	c.291G>T	c.(289-291)GTG>GTT	p.V97V	GABPB2_uc010pcp.1_Silent_p.V113V|GABPB2_uc001ews.2_Silent_p.V57V|GABPB2_uc001ewt.2_5'UTR	NM_144618	NP_653219	Q8TAK5	GABP2_HUMAN	GA repeat binding protein, beta 2	97	ANK 3.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		GTGCAGATGTGAATGCCAAGG	0.443													1	0	2.51308e-46	0.00361	2.75103e-46	90	168										T	151065682	G	T	151065682	2	4	117	1	0	0	0	0	0	0	0	1	6159	1277	45	3		3	GABPB2	1	151065682	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6183020	151065682	98184939	29	35019										
ZNF687	57592	broad.mit.edu	37	chr1	151258795	151258795	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atatgaagacccctgattttGatgacctccttgctgccttt	7	11	0	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:151258795G>C	uc001exq.2	+	2	126	c.28G>C	c.(28-30)GAT>CAT	p.D10H	ZNF687_uc001exp.1_Missense_Mutation_p.D19H|ZNF687_uc009wmo.2_Missense_Mutation_p.D10H|ZNF687_uc009wmp.2_Missense_Mutation_p.D10H	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCCTGATTTTGATGACCTCCT	0.517													0	0	0	0.00361	0	216	139										C	151258795	G	C	151258795	3	2	117	1	0	0	0	0	1	0	0	0	18089	1290	45	1	30	1	ZNF687	1	151258795	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	193113	151258795	97991826	30	35020										
HRNR	388697	broad.mit.edu	37	chr1	152191810	152191810	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gatccagacccttgtcggccGtggcccgaagattgatggga	14	11	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:152191810G>A	uc001ezt.1	-	3	2371	c.2295C>T	c.(2293-2295)CAC>CAT	p.H765H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	765	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGTCGGCCGTGGCCCGAAG	0.592													0	0	0	0.003271	0	32	167										A	152191810	G	A	152191810	2	1	117	1	0	0	0	0	0	0	0	1	7359	1136	40	2		2	HRNR	1	152191810	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	933015	152191810	97058811	31	35021										
HRNR	388697	broad.mit.edu	37	chr1	152193146	152193146	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acccgtgttggccgtggctgGaggagtgccccgaaccggac	16	13	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:152193146G>C	uc001ezt.1	-	3	1035	c.959C>G	c.(958-960)TCC>TGC	p.S320C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	320	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTGGCTGGAGGAGTGCCC	0.607													0	0	0	0.007291	0	27	119										C	152193146	G	C	152193146	3	2	117	1	0	0	0	0	1	0	0	0	7359	1174	41	1	7597	1	HRNR	1	152193146	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1336	152193146	97057475	32	35022										
HRNR	388697	broad.mit.edu	37	chr1	152193539	152193539	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacattggccgcggcctgaaGactgatgggagtcggagttt	15	9	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:152193539G>T	uc001ezt.1	-	3	642	c.566C>A	c.(565-567)TCT>TAT	p.S189Y		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	189	2.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGGCCTGAAGACTGATGGGA	0.537													1	0	2.32416e-17	0.002299	2.49044e-17	5	75										T	152193539	G	T	152193539	3	4	117	1	0	0	0	0	1	0	0	0	7359	942	33	3	7990	3	HRNR	1	152193539	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	393	152193539	97057082	33	35023										
CLK2	1196	broad.mit.edu	37	chr1	155234440	155234440	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccttgccctcccttaccaagGatgacttctggtgctcggta	9	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155234440G>A	uc001fjy.2	-	9	1349	c.1059C>T	c.(1057-1059)ATC>ATT	p.I353I	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjs.2_5'Flank|SCAMP3_uc001fju.2_5'Flank|SCAMP3_uc001fjv.2_5'Flank|SCAMP3_uc001fjt.2_5'Flank|CLK2_uc001fjw.2_Silent_p.I352I|CLK2_uc001fjx.2_Silent_p.I125I|CLK2_uc009wqm.2_Silent_p.I353I	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	353	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCTTACCAAGGATGACTTCTG	0.552								Other_conserved_DNA_damage_response_genes					0	0	0	0.00361	0	37	156										A	155234440	G	A	155234440	2	1	117	1	0	0	0	0	0	0	0	1	3537	1164	41	1		1	CLK2	1	155234440	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3040901	155234440	94016181	34	35024										
YY1AP1	55249	broad.mit.edu	37	chr1	155630385	155630385	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttttgctcggaggggcttctGaatgagttgattgggctggt	16	5	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155630385G>T	uc001fln.2	-	11	1478	c.1454C>A	c.(1453-1455)TCA>TAA	p.S485*	YY1AP1_uc001flg.2_Nonsense_Mutation_p.S224*|YY1AP1_uc010pgg.1_Nonsense_Mutation_p.S324*|YY1AP1_uc010pgh.1_Nonsense_Mutation_p.S428*|YY1AP1_uc010pgi.1_Nonsense_Mutation_p.S577*|YY1AP1_uc001flh.2_Nonsense_Mutation_p.S557*|YY1AP1_uc009wqt.2_Nonsense_Mutation_p.S408*|YY1AP1_uc001flk.2_Nonsense_Mutation_p.S428*|YY1AP1_uc001fll.2_Nonsense_Mutation_p.S439*|YY1AP1_uc009wqv.2_Nonsense_Mutation_p.S156*|YY1AP1_uc001flm.2_Nonsense_Mutation_p.S428*|YY1AP1_uc001fli.2_Nonsense_Mutation_p.S439*|YY1AP1_uc009wqu.2_Nonsense_Mutation_p.S272*|YY1AP1_uc001flj.2_Nonsense_Mutation_p.S419*|YY1AP1_uc009wqw.2_Nonsense_Mutation_p.S408*|YY1AP1_uc001flo.2_Nonsense_Mutation_p.S373*|YY1AP1_uc001flp.2_Nonsense_Mutation_p.S439*|YY1AP1_uc010pgj.1_3'UTR	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	485					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					AGGGGCTTCTGAATGAGTTGA	0.552													1	0	3.52435e-65	0.00361	3.89036e-65	114	69										T	155630385	G	T	155630385	4	4	117	1	0	0	0	0	0	1	0	0	17505	1294	45	3	940	3	YY1AP1	1	155630385	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	395945	155630385	93620236	35	35025										
KIAA0907	22889	broad.mit.edu	37	chr1	155891202	155891202	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggaggctgcacttgtgttatCgggtattgtgttggcacagg	16	6	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155891202C>T	uc001fmi.1	-	10	1254	c.1230G>A	c.(1228-1230)CCG>CCA	p.P410P	KIAA0907_uc001fmj.1_Silent_p.P410P|KIAA0907_uc009wrk.1_Silent_p.P267P|KIAA0907_uc009wrl.1_RNA|SNORA42_uc001fmk.1_5'Flank|KIAA0907_uc001fml.1_Missense_Mutation_p.D377N	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	410	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CTTGTGTTATCGGGTATTGTG	0.493													0	0	0	0.005443	0	23	100										T	155891202	C	T	155891202	2	4	117	1	0	0	0	0	0	0	0	1	8199	871	31	1		1	KIAA0907	1	155891202	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	260817	155891202	93359419	36	35026										
KIAA0907	22889	broad.mit.edu	37	chr1	155903521	155903521	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cagcagcatccaaggctcctGaaggagcagctgtggtgccc	13	13	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:155903521G>A	uc001fmi.1	-	2	182	c.158C>T	c.(157-159)TCA>TTA	p.S53L	KIAA0907_uc001fmj.1_Missense_Mutation_p.S53L|KIAA0907_uc009wrk.1_Missense_Mutation_p.S53L|KIAA0907_uc009wrl.1_RNA|KIAA0907_uc001fml.1_Missense_Mutation_p.S53L|KIAA0907_uc001fmm.2_Missense_Mutation_p.S53L|KIAA0907_uc001fmo.2_Missense_Mutation_p.S53L	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	53											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CAAGGCTCCTGAAGGAGCAGC	0.592													0	0	0	0.006214	0	10	22										A	155903521	G	A	155903521	3	1	117	1	0	0	0	0	1	0	0	0	8199	1294	45	1	1738	1	KIAA0907	1	155903521	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12319	155903521	93347100	37	35027										
SMG5	23381	broad.mit.edu	37	chr1	156230257	156230257	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttacctcctctaaggtgctGagcaggggccgatccgtgtc	12	13	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156230257G>C	uc001foc.3	-	15	2417	c.2268C>G	c.(2266-2268)CTC>CTG	p.L756L	SMG5_uc009wrv.2_Silent_p.L241L	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	756					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					CTAAGGTGCTGAGCAGGGGCC	0.562													0	0	0	0.00361	0	49	161										C	156230257	G	C	156230257	2	2	117	1	0	0	0	0	0	0	0	1	14796	1277	45	1		1	SMG5	1	156230257	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	326736	156230257	93020364	38	35028										
SMG5	23381	broad.mit.edu	37	chr1	156247764	156247764	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acttcatagtatacctttctCcacagcagctcctcagcctt	4	15	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156247764C>G	uc001foc.3	-	3	398	c.249G>C	c.(247-249)TGG>TGC	p.W83C		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	83					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ATACCTTTCTCCACAGCAGCT	0.493													0	0	0	0.009535	0	29	143										G	156247764	C	G	156247764	3	3	117	1	0	0	0	0	1	0	0	0	14796	856	30	1	2881	1	SMG5	1	156247764	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	17507	156247764	93002857	39	35029										
SMG5	23381	broad.mit.edu	37	chr1	156247778	156247778	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttctccacagcagctcctCagcctttctcccatagtcca	4	18	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156247778C>T	uc001foc.3	-	3	384	c.235G>A	c.(235-237)GAG>AAG	p.E79K		NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	79					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					AGCAGCTCCTCAGCCTTTCTC	0.502													0	0	0	0.007291	0	28	118										T	156247778	C	T	156247778	3	4	117	1	0	0	0	0	1	0	0	0	14796	835	29	1	2895	1	SMG5	1	156247778	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	14	156247778	93002843	40	35030										
CCT3	7203	broad.mit.edu	37	chr1	156279057	156279057	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgcctttctttttgtggcctGaaacgatgtcatcaattcgc	8	11	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156279057G>A	uc001fol.1	-	14	1791	c.1571C>T	c.(1570-1572)TCA>TTA	p.S524L	CCT3_uc001fom.1_Missense_Mutation_p.S523L|CCT3_uc001fon.1_Missense_Mutation_p.S486L|CCT3_uc010phj.1_Missense_Mutation_p.S478L|CCT3_uc010phk.1_Missense_Mutation_p.S478L|CCT3_uc010phl.1_Missense_Mutation_p.S478L	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	524					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					TTTGTGGCCTGAAACGATGTC	0.512													0	0	0	0.00623	0	37	183										A	156279057	G	A	156279057	3	1	117	1	0	0	0	0	1	0	0	0	2954	1294	45	1	70	1	CCT3	1	156279057	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	31279	156279057	92971564	41	35031										
C1orf66	51093	broad.mit.edu	37	chr1	156698908	156698908	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaccccgggatgccgggcatCtccgcccgaggcctctctca	12	18	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:156698908C>T	uc001fpu.2	+	1	646	c.12C>T	c.(10-12)ATC>ATT	p.I4I	ISG20L2_uc001fps.1_5'Flank|ISG20L2_uc001fpt.1_5'Flank|C1orf66_uc001fpv.2_Silent_p.I4I	NM_015997	NP_057081	Q96FB5	RRNAD_HUMAN	hypothetical protein LOC51093 isoform 1	4						integral to membrane	rRNA (adenine-N6,N6-)-dimethyltransferase activity				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGCCGGGCATCTCCGCCCGAG	0.642													0	0	0	0.008291	0	10	36										T	156698908	C	T	156698908	2	4	117	1	0	0	0	0	0	0	0	1	2056	903	32	1		1	C1orf66	1	156698908	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	419851	156698908	92551713	42	35032										
OR10X1	128367	broad.mit.edu	37	chr1	158549345	158549345	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccaagaagaagcacatctgTaagctacaacctgtgactga	8	11	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:158549345T>A	uc010pin.1	-	1	345	c.345A>T	c.(343-345)TTA>TTT	p.L115F		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	115	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGCACATCTGTAAGCTACAAC	0.478													0	0	0	0.005443	0	23	129										A	158549345	T	A	158549345	3	1	117	1	0	0	0	0	1	0	0	0	10922	1635	57	5	630	5	OR10X1	1	158549345	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	1850437	158549345	90701276	43	35033										
OR6N2	81442	broad.mit.edu	37	chr1	158747168	158747168	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaaatggttttcttctcactGagaatattagacaacatctt	6	7	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:158747168G>A	uc010pir.1	-	1	258	c.258C>T	c.(256-258)CTC>CTT	p.L86L		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TCTTCTCACTGAGAATATTAG	0.453													0	0	0	0.006214	0	9	232										A	158747168	G	A	158747168	2	1	117	1	0	0	0	0	0	0	0	1	11207	1277	45	1		1	OR6N2	1	158747168	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	197823	158747168	90503453	44	35034										
IFI16	3428	broad.mit.edu	37	chr1	158985757	158985757	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgtcaaaactgaaggagcaGaggcaactcctggagctcag	12	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:158985757G>C	uc001ftf.1	+	4	968	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	IFI16_uc001ftg.2_Missense_Mutation_p.E121Q|IFI16_uc010pis.1_Missense_Mutation_p.E121Q	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	121	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TGAAGGAGCAGAGGCAACTCC	0.522													0	0	0	0.004878	0	33	84										C	158985757	G	C	158985757	3	2	117	1	0	0	0	0	1	0	0	0	7511	943	33	1	367	1	IFI16	1	158985757	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	238589	158985757	90264864	45	35035										
CADM3	57863	broad.mit.edu	37	chr1	159161793	159161793	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtggtgctcaagtgccaagtGaaagatcacgaggactcatc	12	9	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:159161793G>A	uc001ftl.2	+	2	298	c.156G>A	c.(154-156)GTG>GTA	p.V52V	CADM3_uc009wsx.1_Silent_p.V86V|CADM3_uc009wsy.1_Silent_p.V52V|CADM3_uc001ftk.2_Silent_p.V86V	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	52	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					AGTGCCAAGTGAAAGATCACG	0.512													0	0	0	0.00361	0	91	57										A	159161793	G	A	159161793	2	1	117	1	0	0	0	0	0	0	0	1	2568	1277	45	1		1	CADM3	1	159161793	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	176036	159161793	90088828	46	35036										
CADM3	57863	broad.mit.edu	37	chr1	159161862	159161862	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	actctctactttggggagaaGagaggtagtatctcatgagt	12	6	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:159161862G>A	uc001ftl.2	+	2	367	c.225G>A	c.(223-225)AAG>AAA	p.K75K	CADM3_uc009wsx.1_Silent_p.K109K|CADM3_uc009wsy.1_Silent_p.K75K|CADM3_uc001ftk.2_Silent_p.K109K	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	75	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					TTGGGGAGAAGAGAGGTAGTA	0.527													0	0	0	0.00361	0	55	36										A	159161862	G	A	159161862	2	1	117	1	0	0	0	0	0	0	0	1	2568	933	33	1		1	CADM3	1	159161862	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	69	159161862	90088759	47	35037										
COPA	1314	broad.mit.edu	37	chr1	160267134	160267134	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcaagtctcggatacttactCtgtccacagttcttcaggat	8	11	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:160267134C>G	uc009wti.2	-	21	2656	c.2262G>C	c.(2260-2262)CAG>CAC	p.Q754H	COPA_uc001fvv.3_Missense_Mutation_p.Q763H	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	754					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GATACTTACTCTGTCCACAGT	0.453													0	0	0	0.00361	0	39	338										G	160267134	C	G	160267134	3	3	117	1	0	0	0	0	1	0	0	0	3727	927	32	1	1464	1	COPA	1	160267134	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1105272	160267134	88983487	48	35038										
USP21	27005	broad.mit.edu	37	chr1	161130796	161130796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agtggggacttgcgtccaatGgggattgccttgggagggca	18	7	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:161130796G>A	uc010pke.1	+	3	743	c.366G>A	c.(364-366)ATG>ATA	p.M122I	USP21_uc010pkc.1_Missense_Mutation_p.M122I|USP21_uc010pkd.1_Missense_Mutation_p.M122I|USP21_uc010pkf.1_Missense_Mutation_p.M122I	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	122					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGCGTCCAATGGGGATTGCCT	0.632													0	0	0	0.00632	0	24	209										A	161130796	G	A	161130796	3	1	117	1	0	0	0	0	1	0	0	0	17050	1348	47	2	368	2	USP21	1	161130796	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	863662	161130796	88119825	49	35039										
ATF6	22926	broad.mit.edu	37	chr1	161789498	161789498	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agtctcgcaagaagaagaaaGaatatatgctagggttagag	12	4	1	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:161789498G>C	uc001gbr.2	+	8	1052	c.985G>C	c.(985-987)GAA>CAA	p.E329Q	ATF6_uc001gbq.1_Missense_Mutation_p.E329Q	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	329	Cytoplasmic (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GAAGAAGAAAGAATATATGCT	0.413													0	0	0	0.001984	0	7	93										C	161789498	G	C	161789498	3	2	117	1	0	0	0	0	1	0	0	0	1084	943	33	1	1015	1	ATF6	1	161789498	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	658702	161789498	87461123	50	35040										
DUSP27	92235	broad.mit.edu	37	chr1	167096654	167096654	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcagtaccagcggctagctgCctgggggatgaccaagtctc	14	12	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:167096654C>A	uc001geb.1	+	5	2286	c.2286C>A	c.(2284-2286)TGC>TGA	p.C762*		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	762					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CGGCTAGCTGCCTGGGGGATG	0.562													1	0	6.13486e-44	0.00361	6.7046e-44	102	33										A	167096654	C	A	167096654	4	1	117	1	0	0	0	0	0	1	0	0	4824	747	26	4	2304	4	DUSP27	1	167096654	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5307156	167096654	82153967	51	35041										
SCYL3	57147	broad.mit.edu	37	chr1	169847945	169847945	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcttagcaagcaagggtgacGaagtgtcttcaaatgcttta	10	7	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:169847945G>A	uc001ggs.2	-	3	379	c.181C>T	c.(181-183)CGT>TGT	p.R61C	SCYL3_uc001ggt.2_Missense_Mutation_p.R61C|SCYL3_uc001ggu.2_RNA	NM_181093	NP_851607	Q8IZE3	PACE1_HUMAN	SCY1-like 3 isoform 2	61	Protein kinase.				cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			ovary(1)|skin(1)	2	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAAGGGTGACGAAGTGTCTTC	0.408													0	0	0	0.00361	0	113	41										A	169847945	G	A	169847945	3	1	117	1	0	0	0	0	1	0	0	0	13949	1058	37	1	2095	1	SCYL3	1	169847945	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2751291	169847945	79402676	52	35042										
FMO2	2327	broad.mit.edu	37	chr1	171174608	171174608	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctcttttcccttccttgaaGattcactcgttaaagtagag	6	10	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171174608G>T	uc001ghk.1	+	7	1135	c.1018G>T	c.(1018-1020)GAT>TAT	p.D340Y	FMO2_uc010pmd.1_Missense_Mutation_p.D120Y	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	340					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCCTTGAAGATTCACTCGT	0.418													1	0	0.000673444	0.008291	0.000686996	10	27										T	171174608	G	T	171174608	3	4	117	1	0	0	0	0	1	0	0	0	5955	942	33	3	1040	3	FMO2	1	171174608	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1326663	171174608	78076013	53	35043										
FMO4	2329	broad.mit.edu	37	chr1	171292305	171292305	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagaatttgctgagcactttGacctcctgaaatacattcag	7	9	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171292305G>C	uc001gho.2	+	4	512	c.295G>C	c.(295-297)GAC>CAC	p.D99H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	99					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGAGCACTTTGACCTCCTGAA	0.373													0	0	0	0.00874	0	32	44										C	171292305	G	C	171292305	3	2	117	1	0	0	0	0	1	0	0	0	5957	1290	45	1	301	1	FMO4	1	171292305	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	117697	171292305	77958316	54	35044										
FMO4	2329	broad.mit.edu	37	chr1	171293307	171293307	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcagcataacgaagcgtccaGacttctccgaaactggtcag	10	12	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171293307G>C	uc001gho.2	+	5	569	c.352G>C	c.(352-354)GAC>CAC	p.D118H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	118					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GAAGCGTCCAGACTTCTCCGA	0.463													0	0	0	0.00361	0	123	247										C	171293307	G	C	171293307	3	2	117	1	0	0	0	0	1	0	0	0	5957	942	33	1	362	1	FMO4	1	171293307	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1002	171293307	77957314	55	35045										
FMO4	2329	broad.mit.edu	37	chr1	171293376	171293376	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcaaaatagagctgtctttGatgctgttatggtttgcact	10	6	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:171293376G>C	uc001gho.2	+	5	638	c.421G>C	c.(421-423)GAT>CAT	p.D141H		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	141					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					AGCTGTCTTTGATGCTGTTAT	0.478													0	0	0	0.00361	0	260	469										C	171293376	G	C	171293376	3	2	117	1	0	0	0	0	1	0	0	0	5957	1290	45	1	431	1	FMO4	1	171293376	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	69	171293376	77957245	56	35046										
TNN	63923	broad.mit.edu	37	chr1	175087808	175087808	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtatgtggtgcactacacgtCtgccaacggagagaccaggg	14	10	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:175087808C>G	uc001gkl.1	+	11	2611	c.2498C>G	c.(2497-2499)TCT>TGT	p.S833C		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	833	Fibronectin type-III 7.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CACTACACGTCTGCCAACGGA	0.612													0	0	0	0.00361	0	125	42										G	175087808	C	G	175087808	3	3	117	1	0	0	0	0	1	0	0	0	16320	913	32	1	2536	1	TNN	1	175087808	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3794432	175087808	74162813	57	35047										
MR1	3140	broad.mit.edu	37	chr1	181019244	181019244	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tatgacgggcaggatttcctGatcttcaataaagacaccct	8	10	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:181019244G>C	uc001goq.1	+	3	431	c.426G>C	c.(424-426)CTG>CTC	p.L142L	MR1_uc001gop.2_Silent_p.L142L|MR1_uc001gor.1_Intron|MR1_uc001gos.1_Silent_p.L142L|MR1_uc010pns.1_Silent_p.L142L	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	142	Extracellular (Potential).|Ligand-binding.|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						AGGATTTCCTGATCTTCAATA	0.498													0	0	0	0.009718	0	39	47										C	181019244	G	C	181019244	2	2	117	1	0	0	0	0	0	0	0	1	9752	1277	45	1		1	MR1	1	181019244	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5931436	181019244	68231377	58	35048										
UCHL5	51377	broad.mit.edu	37	chr1	193028361	193028361	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	accccggggtcgctttccatGaggcaccactccccggcatt	10	17	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:193028361G>A	uc001gsm.2	-	1	161	c.30C>T	c.(28-30)CTC>CTT	p.L10L	UCHL5_uc001gsn.2_RNA|UCHL5_uc001gso.2_Silent_p.L10L|UCHL5_uc010pov.1_RNA|UCHL5_uc001gsp.2_Silent_p.L10L|UCHL5_uc001gsq.2_Silent_p.L10L|UCHL5_uc010pow.1_Intron|UCHL5_uc010pox.1_5'UTR|UCHL5_uc001gsr.1_3'UTR|TROVE2_uc001gst.1_5'Flank|TROVE2_uc001gss.2_5'Flank|TROVE2_uc001gsu.1_5'Flank|TROVE2_uc001gsv.1_5'Flank|TROVE2_uc001gsw.2_5'Flank|TROVE2_uc009wyp.2_5'Flank|TROVE2_uc009wyq.2_5'Flank	NM_015984	NP_057068	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	10					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3						CGCTTTCCATGAGGCACCACT	0.677													0	0	0	0.004007	0	13	41										A	193028361	G	A	193028361	2	1	117	1	0	0	0	0	0	0	0	1	16919	1277	45	1		1	UCHL5	1	193028361	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12009117	193028361	56222260	59	35049										
CRB1	23418	broad.mit.edu	37	chr1	197398672	197398672	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caagtgggaaagcctgtgagGaggttcagtggtgtggattc	17	5	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:197398672G>T	uc001gtz.2	+	8	2905	c.2770G>T	c.(2770-2772)GAG>TAG	p.E924*	CRB1_uc010poz.1_Nonsense_Mutation_p.E900*|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Nonsense_Mutation_p.E812*|CRB1_uc010ppb.1_Intron|CRB1_uc010ppd.1_Nonsense_Mutation_p.E405*|CRB1_uc001gub.1_Nonsense_Mutation_p.E573*	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	924	Extracellular (Potential).|EGF-like 14.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						AGCCTGTGAGGAGGTTCAGTG	0.547													1	0	8.16721e-17	0.010818	8.70905e-17	28	62										T	197398672	G	T	197398672	4	4	117	1	0	0	0	0	0	1	0	0	3848	1175	41	3	2800	3	CRB1	1	197398672	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4370311	197398672	51851949	60	35050										
ZNF281	23528	broad.mit.edu	37	chr1	200376276	200376276	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tatggtccacttctccattaGagttagtgataaaggtcatt	8	7	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:200376276G>C	uc001gve.2	-	2	2665	c.2558C>G	c.(2557-2559)TCT>TGT	p.S853C	ZNF281_uc001gvf.1_Missense_Mutation_p.S853C|ZNF281_uc001gvg.1_Missense_Mutation_p.S817C	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	853					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TTCTCCATTAGAGTTAGTGAT	0.418													0	0	0	0.00333	0	24	48										C	200376276	G	C	200376276	3	2	117	1	0	0	0	0	1	0	0	0	17815	942	33	1	133	1	ZNF281	1	200376276	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2977604	200376276	48874345	61	35051										
ADIPOR1	51094	broad.mit.edu	37	chr1	202917512	202917512	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tacccgcacctcctcctcttCttcctggggcactgggcatg	9	17	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:202917512C>T	uc001gyq.3	-	3	445	c.178G>A	c.(178-180)GAA>AAA	p.E60K	ADIPOR1_uc010pqd.1_5'UTR|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Missense_Mutation_p.E60K	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	60	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			TCCTCCTCTTCTTCCTGGGGC	0.507													0	0	0	0.001368	0	11	48										T	202917512	C	T	202917512	3	4	117	1	0	0	0	0	1	0	0	0	318	922	32	1	973	1	ADIPOR1	1	202917512	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2541236	202917512	46333109	62	35052										
USH2A	7399	broad.mit.edu	37	chr1	216465553	216465553	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acaatcatcacaaactcctcCtccccctctgaagtgctcaa	3	17	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:216465553C>G	uc001hku.1	-	10	2191	c.1804G>C	c.(1804-1806)GGA>CGA	p.G602R	USH2A_uc001hkv.2_Missense_Mutation_p.G602R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	602	Laminin EGF-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAACTCCTCCTCCCCCTCTG	0.423										HNSCC(13;0.011)			0	0	0	0.011902	0	35	173										G	216465553	C	G	216465553	3	3	117	1	0	0	0	0	1	0	0	0	17033	690	24	4	14070	4	USH2A	1	216465553	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	13548041	216465553	32785068	63	35053										
ESRRG	2104	broad.mit.edu	37	chr1	216850701	216850701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaactgtagctcccactggcGtctgaagagccaccagggct	12	13	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:216850701G>A	uc001hkw.1	-	2	355	c.189C>T	c.(187-189)GAC>GAT	p.D63D	ESRRG_uc001hky.1_Silent_p.D40D|ESRRG_uc009xdp.1_Silent_p.D40D|ESRRG_uc001hkz.1_Silent_p.D40D|ESRRG_uc010puc.1_Silent_p.D40D|ESRRG_uc001hla.1_Silent_p.D40D|ESRRG_uc001hlb.1_Silent_p.D40D|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Silent_p.D40D|ESRRG_uc001hld.1_Silent_p.D40D|ESRRG_uc001hkx.1_Silent_p.D68D|ESRRG_uc009xdo.1_Silent_p.D40D|ESRRG_uc001hle.1_Silent_p.D40D	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	63					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TCCCACTGGCGTCTGAAGAGC	0.572													0	0	0	0.007835	0	39	77										A	216850701	G	A	216850701	2	1	117	1	0	0	0	0	0	0	0	1	5262	1136	40	2		2	ESRRG	1	216850701	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	385148	216850701	32399920	64	35054										
SLC30A10	55532	broad.mit.edu	37	chr1	220089088	220089088	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttctgctccaggggttccttCaagtccacattttcaaactg	7	12	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:220089088C>A	uc001hlw.2	-	4	1372	c.1161G>T	c.(1159-1161)TTG>TTT	p.L387F	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlv.2_Missense_Mutation_p.L142F|SLC30A10_uc001hlx.2_Missense_Mutation_p.L162F	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	387	Cytoplasmic (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GGGGTTCCTTCAAGTCCACAT	0.517													1	0	2.79863e-10	0.004656	2.90899e-10	25	130										A	220089088	C	A	220089088	3	1	117	1	0	0	0	0	1	0	0	0	14554	825	29	3	300	3	SLC30A10	1	220089088	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3238387	220089088	29161533	65	35055										
C1orf65	164127	broad.mit.edu	37	chr1	223566977	223566977	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggactccgggtgcggagagcGaagctggggcgtgctggctg	21	9	0	1	rs143800669		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:223566977G>A	uc001hoa.2	+	1	263	c.160G>A	c.(160-162)GAA>AAA	p.E54K		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	54								p.E54K(1)		central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		TGCGGAGAGCGAAGCTGGGGC	0.736													0	0	0	0.00361	0	45	15										A	223566977	G	A	223566977	3	1	117	1	0	0	0	0	1	0	0	0	2055	1059	37	1	162	1	C1orf65	1	223566977	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3477889	223566977	25683644	66	35056										
GALNT2	2590	broad.mit.edu	37	chr1	230415081	230415081	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atcgagggcaactccaagctGaggcacgtgggcagcaacct	13	12	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:230415081G>C	uc010pwa.1	+	16	1665	c.1593G>C	c.(1591-1593)CTG>CTC	p.L531L	GALNT2_uc010pvy.1_Silent_p.L493L|GALNT2_uc001htu.2_Silent_p.L143L	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	531	Lumenal (Potential).|Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ACTCCAAGCTGAGGCACGTGG	0.582													0	0	0	0.012319	0	18	60										C	230415081	G	C	230415081	2	2	117	1	0	0	0	0	0	0	0	1	6213	1277	45	1		1	GALNT2	1	230415081	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6848104	230415081	18835540	67	35057										
ARID4B	51742	broad.mit.edu	37	chr1	235383127	235383127	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccagattttgctttttcttCctcagcttctacctttatgt	4	12	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:235383127C>A	uc001hwq.2	-	16	2062	c.1564G>T	c.(1564-1566)GAA>TAA	p.E522*	ARID4B_uc001hwr.2_Nonsense_Mutation_p.E522*|ARID4B_uc001hws.3_Nonsense_Mutation_p.E522*|ARID4B_uc001hwt.3_Nonsense_Mutation_p.E203*	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	522	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GCTTTTTCTTCCTCAGCTTCT	0.338													1	0	3.5997e-14	0.002299	3.80161e-14	17	58										A	235383127	C	A	235383127	4	1	117	1	0	0	0	0	0	1	0	0	920	864	30	3	2410	3	ARID4B	1	235383127	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4968046	235383127	13867494	68	35058										
ARID4B	51742	broad.mit.edu	37	chr1	235383646	235383646	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttaatattttcttttctttCaatttcatcctcaataggct	2	9	5	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:235383646C>T	uc001hwq.2	-	15	1876	c.1378G>A	c.(1378-1380)GAA>AAA	p.E460K	ARID4B_uc001hwr.2_Missense_Mutation_p.E460K|ARID4B_uc001hws.3_Missense_Mutation_p.E460K|ARID4B_uc001hwt.3_Missense_Mutation_p.E141K	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	460	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TCTTTTCTTTCAATTTCATCC	0.308													0	0	0	0.004482	0	8	31										T	235383646	C	T	235383646	3	4	117	1	0	0	0	0	1	0	0	0	920	835	29	1	2600	1	ARID4B	1	235383646	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	519	235383646	13866975	69	35059										
TBCE	6905	broad.mit.edu	37	chr1	235611710	235611710	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggattgctgtcacgtcttctCaaagttcctgtgtcagacct	9	11	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:235611710C>G	uc001hwz.1	+	16	1569	c.1446C>G	c.(1444-1446)CTC>CTG	p.L482L	TBCE_uc001hxa.1_Silent_p.L482L|TBCE_uc010pxr.1_Silent_p.L533L|TBCE_uc001hxb.1_Silent_p.L369L|B3GALNT2_uc001hxc.2_3'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	482					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			CACGTCTTCTCAAAGTTCCTG	0.403													0	0	0	0.004289	0	28	117										G	235611710	C	G	235611710	2	3	117	1	0	0	0	0	0	0	0	1	15631	813	29	1		1	TBCE	1	235611710	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	228064	235611710	13638911	70	35060										
FH	2271	broad.mit.edu	37	chr1	241663770	241663770	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gagagctgtcaccaacattaGagactcattcatcagcttgt	8	10	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:241663770G>C	uc001hyx.2	-	9	1389	c.1357C>G	c.(1357-1359)CTA>GTA	p.L453V		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	453					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		ACCAACATTAGAGACTCATTC	0.388			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				0	0	0	0.00361	0	134	70										C	241663770	G	C	241663770	3	2	117	1	0	0	0	0	1	0	0	0	5875	933	33	1	183	1	FH	1	241663770	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6052060	241663770	7586851	71	35061										
OR1C1	26188	broad.mit.edu	37	chr1	247920818	247920818	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	attttctgaagtcccctcttCatatccctgttccttagggt	6	12	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr1:247920818C>T	uc010pza.1	-	1	891	c.891G>A	c.(889-891)ATG>ATA	p.M297I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GTCCCCTCTTCATATCCCTGT	0.428													0	0	0	0.00361	0	61	46										T	247920818	C	T	247920818	3	4	117	1	0	0	0	0	1	0	0	0	10952	826	29	1	55	1	OR1C1	1	247920818	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6257048	247920818	1329803	72	35062										
LAPTM4A	9741	broad.mit.edu	37	chr2	20251207	20251207	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggatgatcgtcccggtgcgGacatggcaacagccgcagca	14	12	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:20251207G>C	uc002rdm.2	-	1	583	c.75C>G	c.(73-75)GTC>GTG	p.V25V	LAPTM4A_uc002rdn.2_5'UTR|LAPTM4A_uc010yjx.1_Silent_p.V25V	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	25					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCCGGTGCGGACATGGCAAC	0.667													0	0	0	0.002299	0	17	16										C	20251207	G	C	20251207	2	2	117	1	0	0	0	0	0	0	0	1	8624	1161	41	1		1	LAPTM4A	2	20251207	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		20251207	222948166	73	35063										
LAPTM4A	9741	broad.mit.edu	37	chr2	20251240	20251240	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccgcagcaccgggtgctgtaGaaccggtcactgcggttccg	14	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:20251240G>A	uc002rdm.2	-	1	550	c.42C>T	c.(40-42)TTC>TTT	p.F14F	LAPTM4A_uc002rdn.2_5'UTR|LAPTM4A_uc010yjx.1_Silent_p.F14F	NM_014713	NP_055528	Q15012	LAP4A_HUMAN	lysosomal protein transmembrane 4 alpha	14					transport	endomembrane system|Golgi apparatus|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGTGCTGTAGAACCGGTCAC	0.642													0	0	0	0.00499	0	13	15										A	20251240	G	A	20251240	2	1	117	1	0	0	0	0	0	0	0	1	8624	933	33	1		1	LAPTM4A	2	20251240	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	33	20251240	222948133	74	35064										
SDC1	6382	broad.mit.edu	37	chr2	20405149	20405149	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agagtcatccccagagccatCttgatcttcagggggcaaat	10	11	4	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:20405149C>T	uc002rdo.1	-	2	402	c.103G>A	c.(103-105)GAT>AAT	p.D35N	SDC1_uc002rdp.1_Missense_Mutation_p.D35N|SDC1_uc010exv.2_Missense_Mutation_p.D35N|SDC1_uc010exw.1_RNA	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	35	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCAGAGCCATCTTGATCTTCA	0.557													0	0	0	0.00361	0	50	114										T	20405149	C	T	20405149	3	4	117	1	0	0	0	0	1	0	0	0	13951	913	32	1	845	1	SDC1	2	20405149	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	153909	20405149	222794224	75	35065										
ASXL2	55252	broad.mit.edu	37	chr2	25990551	25990551	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaagctggagtttgagttttGagggctgcctgtctgtccat	13	7	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:25990551G>A	uc002rgs.2	-	7	897	c.676C>T	c.(676-678)CAA>TAA	p.Q226*	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	226	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGAGTTTTGAGGGCTGCCT	0.418													0	0	0	0.00361	0	77	12										A	25990551	G	A	25990551	4	1	117	1	0	0	0	0	0	1	0	0	1067	1299	45	1	3655	1	ASXL2	2	25990551	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5585402	25990551	217208822	76	35066										
TMEM214	54867	broad.mit.edu	37	chr2	27260564	27260564	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agctgtccccctgagatgaaGaaagaggtgaggatatggtg	15	6	0	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:27260564G>A	uc002ria.3	+	9	1256	c.1146G>A	c.(1144-1146)AAG>AAA	p.K382K	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Silent_p.K337K	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	382						integral to membrane	protein binding				0						CTGAGATGAAGAAAGAGGTGA	0.547													0	0	0	0.004656	0	23	98										A	27260564	G	A	27260564	2	1	117	1	0	0	0	0	0	0	0	1	16134	933	33	1		1	TMEM214	2	27260564	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1270013	27260564	215938809	77	35067										
EIF2AK2	5610	broad.mit.edu	37	chr2	37366873	37366873	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtaccaatactatattctttCtgtcccattttgcatttata	3	9	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:37366873C>T	uc010ynh.1	-	6	974	c.417G>A	c.(415-417)CAG>CAA	p.Q139Q	EIF2AK2_uc010fab.1_Silent_p.Q139Q|EIF2AK2_uc010yng.1_Silent_p.Q139Q|EIF2AK2_uc010fac.2_Silent_p.Q139Q|EIF2AK2_uc010fad.2_Silent_p.Q139Q	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	139	DRBM 2.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TATATTCTTTCTGTCCCATTT	0.323													0	0	0	0.006214	0	8	41										T	37366873	C	T	37366873	2	4	117	1	0	0	0	0	0	0	0	1	4997	912	32	1		1	EIF2AK2	2	37366873	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	10106309	37366873	205832500	78	35068										
SOCS5	9655	broad.mit.edu	37	chr2	46986049	46986049	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gggtgggaagaaaaaacattCctgttctacaaagacccaga	10	8	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:46986049C>T	uc002rvf.2	+	2	544	c.380C>T	c.(379-381)TCC>TTC	p.S127F	SOCS5_uc010yoe.1_Missense_Mutation_p.S96F|SOCS5_uc002rvg.2_Missense_Mutation_p.S127F	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	127					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			AAAAAACATTCCTGTTCTACA	0.443													0	0	0	0.007413	0	18	37										T	46986049	C	T	46986049	3	4	117	1	0	0	0	0	1	0	0	0	14917	855	30	1	382	1	SOCS5	2	46986049	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	9619176	46986049	196213324	79	35069										
FOXN2	3344	broad.mit.edu	37	chr2	48573386	48573386	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	attggaatgactccagataaGagagctgaaaccccaggagc	11	9	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:48573386G>A	uc002rwh.1	+	3	348	c.33G>A	c.(31-33)AAG>AAA	p.K11K		NM_002158	NP_002149	P32314	FOXN2_HUMAN	T-cell leukemia virus enhancer factor	11					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			CTCCAGATAAGAGAGCTGAAA	0.423													0	0	0	0.00361	0	76	15										A	48573386	G	A	48573386	2	1	117	1	0	0	0	0	0	0	0	1	6020	933	33	1		1	FOXN2	2	48573386	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1587337	48573386	194625987	80	35070										
SPTBN1	6711	broad.mit.edu	37	chr2	54858547	54858547	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaggaggactaccagaagatGagggacatgggcgagatggt	18	5	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:54858547G>A	uc002rxu.2	+	16	3612	c.3363G>A	c.(3361-3363)ATG>ATA	p.M1121I	SPTBN1_uc002rxx.2_Missense_Mutation_p.M1108I	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1121	Spectrin 8.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACCAGAAGATGAGGGACATGG	0.587													0	0	0	0.00361	0	75	130										A	54858547	G	A	54858547	3	1	117	1	0	0	0	0	1	0	0	0	15118	1290	45	1	3534	1	SPTBN1	2	54858547	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6285161	54858547	188340826	81	35071										
CCDC88A	55704	broad.mit.edu	37	chr2	55523009	55523009	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtaggtatcttcagtttttcGaggaccaggtctcaaaaact	9	8	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:55523009G>A	uc002ryv.2	-	31	6114	c.5272C>T	c.(5272-5274)CGA>TGA	p.R1758*	CCDC88A_uc010yoz.1_Nonsense_Mutation_p.R1731*|CCDC88A_uc010ypa.1_Intron|CCDC88A_uc002ryt.2_Nonsense_Mutation_p.R49*|CCDC88A_uc010fbw.2_Nonsense_Mutation_p.R260*|CCDC88A_uc002ryu.2_Nonsense_Mutation_p.R1013*|CCDC88A_uc002rys.2_Nonsense_Mutation_p.R716*|CCDC88A_uc002ryw.2_Nonsense_Mutation_p.R1042*|CCDC88A_uc010fby.1_Nonsense_Mutation_p.R610*	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	1759					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TCAGTTTTTCGAGGACCAGGT	0.438													0	0	0	0.00874	0	36	43										A	55523009	G	A	55523009	4	1	117	1	0	0	0	0	0	1	0	0	2863	1066	37	1	348	1	CCDC88A	2	55523009	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	664462	55523009	187676364	82	35072										
SLC1A4	6509	broad.mit.edu	37	chr2	65217170	65217170	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acactgagtgcctcggcgctCgccgtggccttggcgttcat	13	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:65217170C>T	uc010yqa.1	+	1	715	c.393C>T	c.(391-393)CTC>CTT	p.L131L	SLC1A4_uc010ypy.1_Intron|SLC1A4_uc010ypz.1_Intron|SLC1A4_uc010fcv.2_Silent_p.L131L	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	131	Helical; (Potential).				cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	CCTCGGCGCTCGCCGTGGCCT	0.687													0	0	0	0.004656	0	21	3										T	65217170	C	T	65217170	2	4	117	1	0	0	0	0	0	0	0	1	14434	871	31	1		1	SLC1A4	2	65217170	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	9694161	65217170	177982203	83	35073										
DYSF	8291	broad.mit.edu	37	chr2	71730410	71730410	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctagtctgtccgccagcttCaatgcccccctgctggacac	8	18	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:71730410C>T	uc002sie.2	+	4	679	c.303C>T	c.(301-303)TTC>TTT	p.F101F	DYSF_uc010feg.2_Silent_p.F101F|DYSF_uc010feh.2_Silent_p.F101F|DYSF_uc002sig.3_Silent_p.F101F|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.F101F|DYSF_uc010fef.2_Silent_p.F101F|DYSF_uc010fei.2_Silent_p.F101F|DYSF_uc010fek.2_Silent_p.F102F|DYSF_uc010fej.2_Silent_p.F102F|DYSF_uc010fel.2_Silent_p.F102F|DYSF_uc010feo.2_Silent_p.F102F|DYSF_uc010fem.2_Silent_p.F102F|DYSF_uc010fen.2_Silent_p.F102F|DYSF_uc002sif.2_Silent_p.F102F	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	101	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CCGCCAGCTTCAATGCCCCCC	0.577													0	0	0	0.00361	0	219	31										T	71730410	C	T	71730410	2	4	117	1	0	0	0	0	0	0	0	1	4859	825	29	1		1	DYSF	2	71730410	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6513240	71730410	171468963	84	35074										
DYSF	8291	broad.mit.edu	37	chr2	71776507	71776507	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcaggtgctgtcaagccttCgaaagcctcagactgtacgt	11	11	2	1	rs144931729	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:71776507C>T	uc002sie.2	+	17	1884	c.1508C>T	c.(1507-1509)TCG>TTG	p.S503L	DYSF_uc010feg.2_Missense_Mutation_p.S534L|DYSF_uc010feh.2_Intron|DYSF_uc002sig.3_Intron|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.S503L|DYSF_uc010fef.2_Intron|DYSF_uc010fei.2_Intron|DYSF_uc010fek.2_Intron|DYSF_uc010fej.2_Intron|DYSF_uc010fel.2_Intron|DYSF_uc010feo.2_Missense_Mutation_p.S535L|DYSF_uc010fem.2_Missense_Mutation_p.S504L|DYSF_uc010fen.2_Intron|DYSF_uc002sif.2_Missense_Mutation_p.S504L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	503	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GTCAAGCCTTCGAAAGCCTCA	0.577													0	0	0	0.010771	0	36	6										T	71776507	C	T	71776507	3	4	117	1	0	0	0	0	1	0	0	0	4859	893	31	1	1766	1	DYSF	2	71776507	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	46097	71776507	171422866	85	35075										
TET3	200424	broad.mit.edu	37	chr2	74326619	74326619	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgccaagtcctgccgccagCggcagctggaagccagaaag	13	14	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74326619C>T	uc002skb.3	+	8	3079	c.3079C>T	c.(3079-3081)CGG>TGG	p.R1027W		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1027							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTGCCGCCAGCGGCAGCTGGA	0.637													0	0	0	0.003954	0	19	15										T	74326619	C	T	74326619	3	4	117	1	0	0	0	0	1	0	0	0	15768	759	27	2	3109	2	TET3	2	74326619	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2550112	74326619	168872754	86	35076										
BOLA3	388962	broad.mit.edu	37	chr2	74369455	74369455	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctccttaaattcttctgattCaattttaatttcatacatcg	2	9	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74369455C>G	uc002skc.1	-	3	240	c.202G>C	c.(202-204)GAA>CAA	p.E68Q	BOLA3_uc002skd.1_Intron	NM_212552	NP_997717	Q53S33	BOLA3_HUMAN	bolA-like 3 isoform 1	68						extracellular region					0						TCTTCTGATTCAATTTTAATT	0.423													0	0	0	0.010771	0	34	65										G	74369455	C	G	74369455	3	3	117	1	0	0	0	0	1	0	0	0	1486	835	29	1	200	1	BOLA3	2	74369455	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	42836	74369455	168829918	87	35077										
MOGS	7841	broad.mit.edu	37	chr2	74689799	74689799	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttcagctggaaggtcttctCaaagcgctctctaaagcctt	8	12	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74689799C>G	uc010ffj.2	-	4	1280	c.1117G>C	c.(1117-1119)GAG>CAG	p.E373Q	MOGS_uc010ffh.2_Missense_Mutation_p.E98Q|MOGS_uc010yrt.1_Missense_Mutation_p.E254Q|MOGS_uc010ffi.2_Missense_Mutation_p.E267Q	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	373	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AAGGTCTTCTCAAAGCGCTCT	0.587													0	0	0	0.010818	0	33	108										G	74689799	C	G	74689799	3	3	117	1	0	0	0	0	1	0	0	0	9697	835	29	1	1400	1	MOGS	2	74689799	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	320344	74689799	168509574	88	35078										
MOGS	7841	broad.mit.edu	37	chr2	74689864	74689864	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcagtagactgcctgccagtCttggcagggcttgatttcct	11	11	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:74689864C>G	uc010ffj.2	-	4	1215	c.1052G>C	c.(1051-1053)AGA>ACA	p.R351T	MOGS_uc010ffh.2_Missense_Mutation_p.R76T|MOGS_uc010yrt.1_Missense_Mutation_p.R232T|MOGS_uc010ffi.2_Missense_Mutation_p.R245T	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	351	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						GCCTGCCAGTCTTGGCAGGGC	0.532													0	0	0	0.00361	0	69	93										G	74689864	C	G	74689864	3	3	117	1	0	0	0	0	1	0	0	0	9697	913	32	1	1465	1	MOGS	2	74689864	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	65	74689864	168509509	89	35079										
TGOLN2	10618	broad.mit.edu	37	chr2	85554607	85554607	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctttgcctccgcacccgacTtgttgggggtgtcttctggg	13	12	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:85554607T>C	uc010fgd.1	-	2	537	c.248A>G	c.(247-249)AAG>AGG	p.K83R	TGOLN2_uc002soz.2_Missense_Mutation_p.K83R|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.K83R|TGOLN2_uc002spc.1_Missense_Mutation_p.K83R	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	83	Extracellular (Potential).|14 X 14 AA tandem repeats.|3.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CGCACCCGACTTGTTGGGGGT	0.602													0	0	0	0.004482	0	7	533										C	85554607	T	C	85554607	3	2	117	1	0	0	0	0	1	0	0	0	15833	1609	56	5	1077	5	TGOLN2	2	85554607	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	10864743	85554607	157644766	90	35080										
REV1	51455	broad.mit.edu	37	chr2	100052376	100052376	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcattatacagctctgatgtCtgggagaattcaatactgac	9	8	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:100052376C>G	uc002tad.2	-	7	1453	c.1241G>C	c.(1240-1242)AGA>ACA	p.R414T	REV1_uc002tac.2_Missense_Mutation_p.R414T	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	414					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						GCTCTGATGTCTGGGAGAATT	0.348								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00361	0	39	119										G	100052376	C	G	100052376	3	3	117	1	0	0	0	0	1	0	0	0	13239	913	32	1	2582	1	REV1	2	100052376	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	14497769	100052376	143146997	91	35081										
NPAS2	4862	broad.mit.edu	37	chr2	101591943	101591943	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctcccaccaagctgatggcaGaggccagcaccccggctttg	11	16	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:101591943G>A	uc002tap.1	+	14	1592	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	NPAS2_uc010yvt.1_Missense_Mutation_p.E501K|NPAS2_uc010fit.1_Missense_Mutation_p.E14K	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	436					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						GCTGATGGCAGAGGCCAGCAC	0.577													0	0	0	0.00361	0	156	253										A	101591943	G	A	101591943	3	1	117	1	0	0	0	0	1	0	0	0	10563	943	33	1	1356	1	NPAS2	2	101591943	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1539567	101591943	141607430	92	35082										
C2orf29	55571	broad.mit.edu	37	chr2	101885518	101885518	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acagactaactacagctgttGatctacctcctgaatttatt	5	10	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:101885518G>C	uc002taw.3	+	6	1337	c.1255G>C	c.(1255-1257)GAT>CAT	p.D419H		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	419					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TACAGCTGTTGATCTACCTCC	0.279													0	0	0	0.001168	0	5	24										C	101885518	G	C	101885518	3	2	117	1	0	0	0	0	1	0	0	0	2161	1290	45	1	1277	1	C2orf29	2	101885518	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	293575	101885518	141313855	93	35083										
IMP4	92856	broad.mit.edu	37	chr2	131103254	131103254	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccgatctgctggtcgttcacGagcatcggggcacacctggt	13	13	2	0	rs146322628	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:131103254G>A	uc002tra.1	+	5	438	c.421G>A	c.(421-423)GAG>AAG	p.E141K		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	141	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					GGTCGTTCACGAGCATCGGGG	0.667													0	0	0	0.00361	0	48	36										A	131103254	G	A	131103254	3	1	117	1	0	0	0	0	1	0	0	0	7720	1059	37	1	439	1	IMP4	2	131103254	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	29217736	131103254	112096119	94	35084										
FAM123C	205147	broad.mit.edu	37	chr2	131520411	131520411	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gttgtggggaggtgttcgcaGatgagagctcggtgccatct	17	7	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:131520411G>A	uc002trw.2	+	2	956	c.766G>A	c.(766-768)GAT>AAT	p.D256N	FAM123C_uc010fmv.2_Missense_Mutation_p.D256N|FAM123C_uc010fms.1_Missense_Mutation_p.D256N|FAM123C_uc010fmt.1_Missense_Mutation_p.D256N|FAM123C_uc010fmu.1_Missense_Mutation_p.D256N	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	256										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GGTGTTCGCAGATGAGAGCTC	0.647													0	0	0	0.00361	0	58	54										A	131520411	G	A	131520411	3	1	117	1	0	0	0	0	1	0	0	0	5424	942	33	1	768	1	FAM123C	2	131520411	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	417157	131520411	111678962	95	35085										
LRP1B	53353	broad.mit.edu	37	chr2	141625324	141625324	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atatagagacacagcaaaggGatgggaaaggtattcatgac	12	5	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:141625324G>C	uc002tvj.1	-	27	5386	c.4414C>G	c.(4414-4416)CCC>GCC	p.P1472A	LRP1B_uc010fnl.1_Missense_Mutation_p.P654A	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1472	Extracellular (Potential).|LDL-receptor class B 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACAGCAAAGGGATGGGAAAGG	0.428										TSP Lung(27;0.18)			0	0	0	0.009096	0	4	78										C	141625324	G	C	141625324	3	2	117	1	0	0	0	0	1	0	0	0	8955	1174	41	1	9645	1	LRP1B	2	141625324	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	10104913	141625324	101574049	96	35086										
NEB	4703	broad.mit.edu	37	chr2	152468805	152468805	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggcgatacttcctgtcactCaggatttctccagctctctt	7	13	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:152468805C>G	uc010fnx.2	-	74	11162	c.10971G>C	c.(10969-10971)CTG>CTC	p.L3657L		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3657	Nebulin 100.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCCTGTCACTCAGGATTTCTC	0.473													0	0	0	0.00361	0	49	6										G	152468805	C	G	152468805	2	3	117	1	0	0	0	0	0	0	0	1	10302	813	29	1		1	NEB	2	152468805	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	10843481	152468805	90730568	97	35087										
HOXD13	3239	broad.mit.edu	37	chr2	176958267	176958267	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtccactttcggctccgggGagcctcggcacgaggcctac	13	15	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:176958267G>A	uc002ukf.1	+	1	736	c.649G>A	c.(649-651)GAG>AAG	p.E217K		NM_000523	NP_000514	P35453	HXD13_HUMAN	homeobox D13	217					skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		CGGCTCCGGGGAGCCTCGGCA	0.617			T	NUP98	AML*								0	0	0	0.00361	0	67	12										A	176958267	G	A	176958267	3	1	117	1	0	0	0	0	1	0	0	0	7322	1175	41	1	651	1	HOXD13	2	176958267	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	24489462	176958267	66241106	98	35088										
COL5A2	1290	broad.mit.edu	37	chr2	189931201	189931201	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttcaccgggtgggcctatcGgaccctgaataccatgtggc	12	13	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:189931201G>A	uc002uqk.2	-	23	1753	c.1478C>T	c.(1477-1479)CCG>CTG	p.P493L	COL5A2_uc010frx.2_Intron	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	493					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TGGGCCTATCGGACCCTGAAT	0.478													0	0	0	0.00361	0	51	136										A	189931201	G	A	189931201	3	1	117	1	0	0	0	0	1	0	0	0	3697	1116	39	2	3149	2	COL5A2	2	189931201	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12972934	189931201	53268172	99	35089										
AOX1	316	broad.mit.edu	37	chr2	201469496	201469496	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggttttcccccgtgaccctGaaggaactgctggaatttaa	10	10	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:201469496G>T	uc002uvx.2	+	9	848	c.747G>T	c.(745-747)CTG>CTT	p.L249L		NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	249	FAD-binding PCMH-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCGTGACCCTGAAGGAACTGC	0.448													1	0	3.27315e-48	0.00361	3.59501e-48	85	41										T	201469496	G	T	201469496	2	4	117	1	0	0	0	0	0	0	0	1	729	1277	45	3		3	AOX1	2	201469496	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	11538295	201469496	41729877	100	35090										
ICOS	29851	broad.mit.edu	37	chr2	204820542	204820542	+	Missense_Mutation	SNP	A	A	T													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agtgtccattaagagtctgaAattctgccattctcagttat							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:204820542A>T	uc002vam.2	+	2	309	c.242A>T	c.(241-243)AAA>ATA	p.K81I	ICOS_uc010zip.1_Missense_Mutation_p.K81I|ICOS_uc010fua.2_Missense_Mutation_p.K81I	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	81	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	extracellular region					0						AAGAGTCTGAAATTCTGCCAT	0.388													0	0	0	0.010818	0	29	63										T	204820542	A	T	204820542	3	4	117	1	0	0	0	0	1	0	0	0	7486	14	1	5	248	5	ICOS	2	204820542	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	3351046	204820542	38378831	101	35091	179	2								
ICOS	29851	broad.mit.edu	37	chr2	204820544	204820544	+	Missense_Mutation	SNP	T	T	C													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtccattaagagtctgaaaTtctgccattctcagttatcc							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:204820544T>C	uc002vam.2	+	2	311	c.244T>C	c.(244-246)TTC>CTC	p.F82L	ICOS_uc010zip.1_Missense_Mutation_p.F82L|ICOS_uc010fua.2_Missense_Mutation_p.F82L	NM_012092	NP_036224	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator precursor	82	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	extracellular region					0						GAGTCTGAAATTCTGCCATTC	0.388													0	0	0	0.010818	0	28	61										C	204820544	T	C	204820544	3	2	117	1	0	0	0	0	1	0	0	0	7486	1493	52	5	250	5	ICOS	2	204820544	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	2	204820544	38378829	102	35092	179	2								
BARD1	580	broad.mit.edu	37	chr2	215645993	215645993	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctttttttgcttttttccaGatcttgcagaagccttttta	5	8	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:215645993G>C	uc002veu.2	-	4	740	c.605C>G	c.(604-606)TCT>TGT	p.S202C	BARD1_uc010zjm.1_Missense_Mutation_p.S58C	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	202					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTTTTTTCCAGATCTTGCAGA	0.368									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				0	0	0	0.001984	0	7	15										C	215645993	G	C	215645993	3	2	117	1	0	0	0	0	1	0	0	0	1312	942	33	1	1760	1	BARD1	2	215645993	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	10825449	215645993	27553380	103	35093										
OBSL1	23363	broad.mit.edu	37	chr2	220432452	220432452	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccctcacattttactctgaGaagcgtagtggtacgggagt	12	9	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:220432452G>A	uc010fwk.2	-	3	1579	c.1522C>T	c.(1522-1524)CTC>TTC	p.L508F	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.L508F|OBSL1_uc002vmj.2_Missense_Mutation_p.L95F	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	508					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		TTTACTCTGAGAAGCGTAGTG	0.597													0	0	0	0.005443	0	22	66										A	220432452	G	A	220432452	3	1	117	1	0	0	0	0	1	0	0	0	10813	942	33	1	4396	1	OBSL1	2	220432452	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4786459	220432452	22766921	104	35094										
MFF	56947	broad.mit.edu	37	chr2	228205033	228205033	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcagttggcagactaaaaaGagagcggtctatgagtgaaa	13	5	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:228205033G>C	uc002vos.2	+	6	873	c.455G>C	c.(454-456)AGA>ACA	p.R152T	MFF_uc002vot.2_Missense_Mutation_p.R126T|MFF_uc002vou.2_Missense_Mutation_p.R152T|MFF_uc002vov.2_Missense_Mutation_p.R126T|MFF_uc002vow.2_Missense_Mutation_p.R126T|MFF_uc002vox.2_Missense_Mutation_p.R126T|MFF_uc002voy.2_Missense_Mutation_p.R152T|MFF_uc002voz.2_Missense_Mutation_p.R126T	NM_020194	NP_064579	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	152	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane				large_intestine(1)	1						AGACTAAAAAGAGAGCGGTCT	0.413													0	0	0	0.00874	0	28	18										C	228205033	G	C	228205033	3	2	117	1	0	0	0	0	1	0	0	0	9519	942	33	1	469	1	MFF	2	228205033	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	7772581	228205033	14994340	105	35095										
USP40	55230	broad.mit.edu	37	chr2	234386116	234386116	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcgtctctgcactggagagGatgtagctgctctgctcatg	14	10	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr2:234386116G>A	uc010zmr.1	-	31	3666	c.3666C>T	c.(3664-3666)ATC>ATT	p.I1222I	USP40_uc002vul.2_Silent_p.I206I	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	1210					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CACTGGAGAGGATGTAGCTGC	0.602													0	0	0	0.006122	0	15	45										A	234386116	G	A	234386116	2	1	117	1	0	0	0	0	0	0	0	1	17069	1164	41	1		1	USP40	2	234386116	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6181083	234386116	8813257	106	35096										
TMEM40	55287	broad.mit.edu	37	chr3	12783978	12783978	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tagagttgaagctcatccttCaaaacgtcaggctccccatg	8	12	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:12783978C>G	uc003bxg.1	-	5	457	c.330G>C	c.(328-330)TTG>TTC	p.L110F	TMEM40_uc003bxh.1_Missense_Mutation_p.L80F|TMEM40_uc003bxi.1_Missense_Mutation_p.L34F|TMEM40_uc011auv.1_Missense_Mutation_p.L126F	NM_018306	NP_060776	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	110						integral to membrane					0						GCTCATCCTTCAAAACGTCAG	0.517													0	0	0	0.00361	0	74	98										G	12783978	C	G	12783978	3	3	117	1	0	0	0	0	1	0	0	0	16160	825	29	1	403	1	TMEM40	3	12783978	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		12783978	185238452	107	35097										
GRIP2	80852	broad.mit.edu	37	chr3	14583429	14583429	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcagggagaggctcgccatGaagaccctggccttcaccag	13	13	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:14583429G>T	uc011avi.1	-	1	160	c.160C>A	c.(160-162)CAT>AAT	p.H54N	GRIP2_uc011avh.1_5'Flank|GRIP2_uc003byv.1_5'Flank	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	Error:Variant_position_missing_in_Q9C0E4_after_alignment					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						GGCTCGCCATGAAGACCCTGG	0.572													1	0	1.33987e-11	0.008291	1.40155e-11	8	12										T	14583429	G	T	14583429	3	4	117	1	0	0	0	0	1	0	0	0	6788	1290	45	3	3364	3	GRIP2	3	14583429	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1799451	14583429	183439001	108	35098										
MRPS25	64432	broad.mit.edu	37	chr3	15094937	15094937	+	Missense_Mutation	SNP	C	C	G													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tccatgatctccttattgctCttggtctccacatccaccag							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:15094937C>G	uc003bzl.2	-	3	394	c.279G>C	c.(277-279)AAG>AAC	p.K93N	MRPS25_uc011avl.1_Intron|MRPS25_uc011avm.1_Missense_Mutation_p.K93N	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	93					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CCTTATTGCTCTTGGTCTCCA	0.488													0	0	0	0.00278	0	18	58										G	15094937	C	G	15094937	3	3	117	1	0	0	0	0	1	0	0	0	9836	912	32	1	250	1	MRPS25	3	15094937	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	511508	15094937	182927493	109	35099	180	2								
MRPS25	64432	broad.mit.edu	37	chr3	15094945	15094945	+	Missense_Mutation	SNP	C	C	G													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctccttattgctcttggtctCcacatccaccaggacctgct							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:15094945C>G	uc003bzl.2	-	3	386	c.271G>C	c.(271-273)GAG>CAG	p.E91Q	MRPS25_uc011avl.1_Intron|MRPS25_uc011avm.1_Missense_Mutation_p.E91Q	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	91					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CTCTTGGTCTCCACATCCACC	0.473													0	0	0	0.00278	0	17	58										G	15094945	C	G	15094945	3	3	117	1	0	0	0	0	1	0	0	0	9836	864	30	1	258	1	MRPS25	3	15094945	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	8	15094945	182927485	110	35100	180	2								
EFHB	151651	broad.mit.edu	37	chr3	19975088	19975088	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccaaaggagctctcctgctCcctgcagcctgtgaacttcc	9	16	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:19975088C>A	uc003cbl.3	-	1	619	c.423G>T	c.(421-423)GGG>GGT	p.G141G	EFHB_uc003cbm.2_Intron	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	141					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CTCTCCTGCTCCCTGCAGCCT	0.493													1	0	4.26978e-12	0.00333	4.48055e-12	21	82										A	19975088	C	A	19975088	2	1	117	1	0	0	0	0	0	0	0	1	4945	842	30	3		3	EFHB	3	19975088	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4880143	19975088	178047342	111	35101										
SCN5A	6331	broad.mit.edu	37	chr3	38622656	38622656	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgcagctgggcagctggccCtgggcggcaagggctgcggg	20	11	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:38622656C>G	uc003cio.2	-	17	3188	c.2994G>C	c.(2992-2994)CAG>CAC	p.Q998H	SCN5A_uc003cin.2_Missense_Mutation_p.Q998H|SCN5A_uc003cil.3_Missense_Mutation_p.Q998H|SCN5A_uc010hhi.2_Missense_Mutation_p.Q998H|SCN5A_uc010hhk.2_Missense_Mutation_p.Q998H|SCN5A_uc011ayr.1_Missense_Mutation_p.Q998H|SCN5A_uc010hhj.1_Missense_Mutation_p.Q609H	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	998					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GCAGCTGGCCCTGGGCGGCAA	0.672													0	0	0	0.003163	0	14	15										G	38622656	C	G	38622656	3	3	117	1	0	0	0	0	1	0	0	0	13922	680	24	4	3104	4	SCN5A	3	38622656	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	18647568	38622656	159399774	112	35102										
HHATL	57467	broad.mit.edu	37	chr3	42734575	42734575	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccctgtccctcacctgtgaGtagcaggcgccgggcaacca	11	17	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:42734575G>A	uc003clw.2	-	12	1531	c.1384C>T	c.(1384-1386)CTC>TTC	p.L462F	HHATL_uc003clx.2_Missense_Mutation_p.L462F	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	462	Helical; (Potential).				negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TCACCTGTGAGTAGCAGGCGC	0.567													0	0	0	0.009096	0	4	264										A	42734575	G	A	42734575	3	1	117	1	0	0	0	0	1	0	0	0	7090	1029	36	2	138	2	HHATL	3	42734575	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4111919	42734575	155287855	113	35103										
BSN	8927	broad.mit.edu	37	chr3	49698105	49698105	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccaaggccagcctgctccggGagctggaccgggacctgcgg	16	15	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:49698105G>A	uc003cxe.3	+	6	8941	c.8827G>A	c.(8827-8829)GAG>AAG	p.E2943K		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2943	Potential.				synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCTGCTCCGGGAGCTGGACCG	0.657													0	0	0	0.008291	0	7	22										A	49698105	G	A	49698105	3	1	117	1	0	0	0	0	1	0	0	0	1530	1175	41	1	8849	1	BSN	3	49698105	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6963530	49698105	148324325	114	35104										
C3orf54	389119	broad.mit.edu	37	chr3	49842359	49842359	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcggatgtctcacgctttgCagctctcatgagctgtcgta	11	11	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:49842359C>A	uc003cxq.1	+	2	936	c.803C>A	c.(802-804)GCA>GAA	p.A268E		NM_203370	NP_976248	Q96EL1	CC054_HUMAN	hypothetical protein LOC389119	266											0				BRCA - Breast invasive adenocarcinoma(193;3.55e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TCACGCTTTGCAGCTCTCATG	0.597													1	0	1.23719e-20	0.00361	1.33658e-20	70	216										A	49842359	C	A	49842359	3	1	117	1	0	0	0	0	1	0	0	0	2233	710	25	4	809	4	C3orf54	3	49842359	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	144254	49842359	148180071	115	35105										
SEMA3B	7869	broad.mit.edu	37	chr3	50314055	50314055	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcagtcactgcccctggagtCgcggagaaagggccgtaacc	14	13	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:50314055C>T	uc003cyu.2	+	19	2410	c.2168C>T	c.(2167-2169)TCG>TTG	p.S723L	SEMA3B_uc003cyt.2_Missense_Mutation_p.S722L|SEMA3B_uc003cyv.2_Missense_Mutation_p.S610L|SEMA3B_uc003cyw.2_Missense_Mutation_p.S446L|SEMA3B_uc010hli.2_Missense_Mutation_p.S615L|SEMA3B_uc003cyx.2_Missense_Mutation_p.S609L|SEMA3B_uc003cyy.2_Missense_Mutation_p.S380L|SEMA3B_uc011bdo.1_Missense_Mutation_p.S380L|C3orf45_uc003cyz.2_5'Flank	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	723					axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CCCCTGGAGTCGCGGAGAAAG	0.721													0	0	0	0.00499	0	14	8										T	50314055	C	T	50314055	3	4	117	1	0	0	0	0	1	0	0	0	14025	893	31	1	2233	1	SEMA3B	3	50314055	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	471696	50314055	147708375	116	35106										
ACY1	95	broad.mit.edu	37	chr3	52019910	52019910	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttgaggccttcaaggattctGagggctacatctatgccagg	12	9	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:52019910G>C	uc003dcp.2	+	5	368	c.307G>C	c.(307-309)GAG>CAG	p.E103Q	ABHD14B_uc003dcn.2_5'Flank|ACY1_uc011bea.1_Missense_Mutation_p.E193Q|ACY1_uc011beb.1_Missense_Mutation_p.E103Q|ACY1_uc003dcq.2_Missense_Mutation_p.E103Q	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	103					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CAAGGATTCTGAGGGCTACAT	0.552													0	0	0	0.010729	0	9	19										C	52019910	G	C	52019910	3	2	117	1	0	0	0	0	1	0	0	0	226	1291	45	1	321	1	ACY1	3	52019910	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1705855	52019910	146002520	117	35107										
ACTR8	93973	broad.mit.edu	37	chr3	53905383	53905383	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcggaatcgttgccggccatCaggccatctccctgtgcaga	11	14	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:53905383C>A	uc003dhd.2	-	11	1502	c.1443G>T	c.(1441-1443)CTG>CTT	p.L481L	ACTR8_uc003dhb.2_Silent_p.L186L|ACTR8_uc003dhc.2_Silent_p.L370L	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	481					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		TGCCGGCCATCAGGCCATCTC	0.547													1	0	2.65435e-51	0.00361	2.92023e-51	87	78										A	53905383	C	A	53905383	2	1	117	1	0	0	0	0	0	0	0	1	217	813	29	3		3	ACTR8	3	53905383	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1885473	53905383	144117047	118	35108										
FAM3D	131177	broad.mit.edu	37	chr3	58631354	58631354	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acacttgtactttttaacctCtggggaggaaagagaccagc	10	9	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:58631354C>G	uc003dkq.2	-	5	443	c.146_splice	c.e5-1	p.Q49_splice		NM_138805	NP_620160	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D						negative regulation of insulin secretion	extracellular region	cytokine activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		TTTTTAACCTCTGGGGAGGAA	0.587													0	0	0	0.00361	0	57	34										G	58631354	C	G	58631354	5	3	117	1	0	0	0	0	0	0	1	0	5559	927	32	1	553	1	FAM3D	3	58631354	Splice_Site	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4725971	58631354	139391076	119	35109										
SHQ1	55164	broad.mit.edu	37	chr3	72890342	72890342	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aactacttcctcaggaatctCagaagcacctgaatgtgtta	7	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:72890342C>G	uc003dpf.2	-	4	447	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	SHQ1_uc010hod.2_Missense_Mutation_p.E25Q	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	114					ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		TCAGGAATCTCAGAAGCACCT	0.338													0	0	0	0.001368	0	13	21										G	72890342	C	G	72890342	3	3	117	1	0	0	0	0	1	0	0	0	14292	835	29	1	1425	1	SHQ1	3	72890342	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	14258988	72890342	125132088	120	35110										
CNTN3	5067	broad.mit.edu	37	chr3	74344388	74344388	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agatggggccactgtaggctCtgttcggaaacagaaattga	13	7	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:74344388C>G	uc003dpm.1	-	18	2482	c.2402_splice	c.e18-1	p.E801_splice		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACTGTAGGCTCTGTTCGGAAA	0.353													0	0	0	0.006999	0	37	23										G	74344388	C	G	74344388	5	3	117	1	0	0	0	0	0	0	1	0	3642	927	32	1	705	1	CNTN3	3	74344388	Splice_Site	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1454046	74344388	123678042	121	35111										
ST3GAL6	10402	broad.mit.edu	37	chr3	98510824	98510824	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctatgggaatgccaccatgtCtttgatgaataaggtaatat	9	6	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:98510824C>T	uc003dsz.2	+	9	1132	c.896C>T	c.(895-897)TCT>TTT	p.S299F	ST3GAL6_uc003dsy.2_Missense_Mutation_p.S213F|ST3GAL6_uc003dta.2_Missense_Mutation_p.S181F|ST3GAL6_uc003dtb.2_Missense_Mutation_p.S155F|ST3GAL6_uc003dtc.2_Missense_Mutation_p.S299F|ST3GAL6_uc010hpd.2_Missense_Mutation_p.S352F	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	299	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						GCCACCATGTCTTTGATGAAT	0.373													0	0	0	0.009535	0	23	53										T	98510824	C	T	98510824	3	4	117	1	0	0	0	0	1	0	0	0	15218	913	32	1	926	1	ST3GAL6	3	98510824	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	24166436	98510824	99511606	122	35112										
IMPG2	50939	broad.mit.edu	37	chr3	101038512	101038512	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tttcactccattaggaaacaGaatagatctccgccttctga	6	11	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:101038512G>A	uc003duq.1	-	2	453	c.250C>T	c.(250-252)CTG>TTG	p.L84L	IMPG2_uc011bhe.1_5'UTR	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	84	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTAGGAAACAGAATAGATCTC	0.428													0	0	0	0.00632	0	27	85										A	101038512	G	A	101038512	2	1	117	1	0	0	0	0	0	0	0	1	7729	933	33	1		1	IMPG2	3	101038512	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2527688	101038512	96983918	123	35113										
CBLB	868	broad.mit.edu	37	chr3	105421029	105421029	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtgccttccattgacatttGaactcgctgtgattccaggt	9	10	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:105421029G>C	uc003dwc.2	-	12	2190	c.1868C>G	c.(1867-1869)TCA>TGA	p.S623*	CBLB_uc011bhi.1_Nonsense_Mutation_p.S645*|CBLB_uc003dwd.1_Nonsense_Mutation_p.S623*|CBLB_uc003dwe.1_Nonsense_Mutation_p.S623*	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	623	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						ATTGACATTTGAACTCGCTGT	0.502			Mis S		AML								0	0	0	0.010504	0	21	51										C	105421029	G	C	105421029	4	2	117	1	0	0	0	0	0	1	0	0	2701	1294	45	1	1112	1	CBLB	3	105421029	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4382517	105421029	92601401	124	35114										
CCDC80	151887	broad.mit.edu	37	chr3	112358139	112358139	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctccaggatctggccctcgCtggtgatccttctcaccttg	10	15	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:112358139C>T	uc003dzf.2	-	2	832	c.614G>A	c.(613-615)AGC>AAC	p.S205N	CCDC80_uc011bhv.1_Missense_Mutation_p.S205N|CCDC80_uc003dzg.2_Missense_Mutation_p.S205N|CCDC80_uc003dzh.1_Missense_Mutation_p.S205N	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	205										ovary(2)	2						CTGGCCCTCGCTGGTGATCCT	0.577													0	0	0	0.00361	0	59	61										T	112358139	C	T	112358139	3	4	117	1	0	0	0	0	1	0	0	0	2854	797	28	2	2266	2	CCDC80	3	112358139	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6937110	112358139	85664291	125	35115										
IQCB1	9657	broad.mit.edu	37	chr3	121509013	121509013	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caattgtaatttgaggtcctCttcttccttctgcctattta	5	10	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:121509013C>A	uc010hre.1	-	11	1251	c.1036G>T	c.(1036-1038)GAG>TAG	p.E346*	IQCB1_uc003eek.2_Nonsense_Mutation_p.E213*|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	346	Potential.				cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TTGAGGTCCTCTTCTTCCTTC	0.373													1	0	6.02501e-08	0.00623	6.21359e-08	34	104										A	121509013	C	A	121509013	4	1	117	1	0	0	0	0	0	1	0	0	7803	922	32	3	780	3	IQCB1	3	121509013	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	9150874	121509013	76513417	126	35116										
SLC15A2	6565	broad.mit.edu	37	chr3	121642098	121642098	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggactttgcaagccatcagGatgaataggaatttggtgag	13	5	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:121642098G>A	uc003eep.2	+	11	1140	c.987G>A	c.(985-987)AGG>AGA	p.R329R	SLC15A2_uc011bjn.1_Silent_p.R298R	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	329					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AAGCCATCAGGATGAATAGGA	0.403													0	0	0	0.008871	0	18	63										A	121642098	G	A	121642098	2	1	117	1	0	0	0	0	0	0	0	1	14399	1165	41	1		1	SLC15A2	3	121642098	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	133085	121642098	76380332	127	35117										
ZNF148	7707	broad.mit.edu	37	chr3	124952313	124952313	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcatactttgaaactttgctCtcttcatatgtggataaagg	8	7	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:124952313C>A	uc003ehx.3	-	9	1743	c.1257G>T	c.(1255-1257)GAG>GAT	p.E419D	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Missense_Mutation_p.E419D|ZNF148_uc010hsa.2_Missense_Mutation_p.E419D|ZNF148_uc003eia.3_Missense_Mutation_p.E419D|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	419					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						AAACTTTGCTCTCTTCATATG	0.373													1	0	4.36969e-10	0.001855	4.53484e-10	13	49										A	124952313	C	A	124952313	3	1	117	1	0	0	0	0	1	0	0	0	17731	912	32	3	1131	3	ZNF148	3	124952313	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3310215	124952313	73070117	128	35118										
H1FOO	132243	broad.mit.edu	37	chr3	129268112	129268113	+	Frame_Shift_Ins	INS	-	-	G													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cagtcgggagaggctaggaaINSggtgccccccaagccagaca							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:129268112_129268113insG	uc003emu.2	+	3	652_653	c.647_648insG	c.(646-648)AAGfs	p.K216fs	H1FOO_uc003emv.2_Frame_Shift_Ins_p.K77fs	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	216					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						GAGGCTAGGAAGGTGCCCCCCA	0.649																		3	6	---	---								G	129268113	-	G	129268112	7	5	117	1	0	1	1	0	0	0	0	0	6922	72	3	0	657	0	H1FOO	3	129268112	Frame_Shift_Ins	INS	-	TCGA-GV-A3JZ-01A-11D-A21A-08	4315799	129268112	68754318	129	35119										
COL6A6	131873	broad.mit.edu	37	chr3	130292929	130292929	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttgatgtcagcctcaacaGagtgcgaataggagcggccc	12	11	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:130292929G>A	uc010htl.2	+	7	3138	c.3107G>A	c.(3106-3108)AGA>AAA	p.R1036K		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1036	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AGCCTCAACAGAGTGCGAATA	0.418													0	0	0	0.004672	0	3	12										A	130292929	G	A	130292929	3	1	117	1	0	0	0	0	1	0	0	0	3703	942	33	1	3133	1	COL6A6	3	130292929	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1024817	130292929	67729501	130	35120										
SLCO2A1	6578	broad.mit.edu	37	chr3	133670119	133670119	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggtgagaaccaataaagctGaagaaatgagcaggcctagc	12	7	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:133670119G>A	uc003eqa.3	-	6	1068	c.794C>T	c.(793-795)TCA>TTA	p.S265L	SLCO2A1_uc003eqb.3_Missense_Mutation_p.S189L|SLCO2A1_uc011blv.1_Intron|SLCO2A1_uc010htw.1_Missense_Mutation_p.S97L	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	265	Helical; Name=6; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						CAATAAAGCTGAAGAAATGAG	0.493													0	0	0	0.012213	0	33	33										A	133670119	G	A	133670119	3	1	117	1	0	0	0	0	1	0	0	0	14726	1294	45	1	1173	1	SLCO2A1	3	133670119	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3377190	133670119	64352311	131	35121										
PPP2R3A	5523	broad.mit.edu	37	chr3	135820922	135820922	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtatgagctggagtacttcTatgaggagcagtgtgaacgg	15	5	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:135820922T>C	uc003eqv.1	+	11	3566	c.3001T>C	c.(3001-3003)TAT>CAT	p.Y1001H	PPP2R3A_uc011blz.1_Missense_Mutation_p.Y265H|PPP2R3A_uc003eqw.1_Missense_Mutation_p.Y380H	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	1001	EF-hand 2.				protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						GGAGTACTTCTATGAGGAGCA	0.468													0	0	0	0.00333	0	22	29										C	135820922	T	C	135820922	3	2	117	1	0	0	0	0	1	0	0	0	12388	1522	53	5	3175	5	PPP2R3A	3	135820922	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	2150803	135820922	62201508	132	35122										
PAQR9	344838	broad.mit.edu	37	chr3	142682017	142682017	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gacaggatgaagcactccacGaagtcgtcgggcacctcgtc	12	13	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:142682017G>A	uc003evg.2	-	1	162	c.162C>T	c.(160-162)TTC>TTT	p.F54F	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	54	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AGCACTCCACGAAGTCGTCGG	0.687													0	0	0	0.00308	0	7	5										A	142682017	G	A	142682017	2	1	117	1	0	0	0	0	0	0	0	1	11442	1049	37	1		1	PAQR9	3	142682017	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6861095	142682017	55340413	133	35123										
TM4SF4	7104	broad.mit.edu	37	chr3	149220466	149220466	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccttttctaccttctagggaGatggacccgtttaaacctcc	7	13	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:149220466G>C	uc003exd.1	+	5	826	c.595G>C	c.(595-597)GAT>CAT	p.D199H		NM_004617	NP_004608	P48230	T4S4_HUMAN	transmembrane 4 superfamily member 4	199	Cytoplasmic (Potential).					integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CTTCTAGGGAGATGGACCCGT	0.403													0	0	0	0.00361	0	63	42										C	149220466	G	C	149220466	3	2	117	1	0	0	0	0	1	0	0	0	15967	942	33	1	613	1	TM4SF4	3	149220466	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6538449	149220466	48801964	134	35124										
SI	6476	broad.mit.edu	37	chr3	164733762	164733762	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggataataatgtatctcattCcttctcctcttattttgtca	4	9	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:164733762C>T	uc003fei.2	-	32	3928	c.3866G>A	c.(3865-3867)GGA>GAA	p.G1289E		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1289	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTATCTCATTCCTTCTCCTCT	0.403										HNSCC(35;0.089)			0	0	0	0.010504	0	17	69										T	164733762	C	T	164733762	3	4	117	1	0	0	0	0	1	0	0	0	14297	855	30	1	1685	1	SI	3	164733762	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	15513296	164733762	33288668	135	35125										
MECOM	2122	broad.mit.edu	37	chr3	168834306	168834306	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	attaaccatggacgttttatCcatagctggggttccaggaa	10	8	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:168834306C>A	uc003ffi.3	-	7	1059	c.790G>T	c.(790-792)GAT>TAT	p.D264Y	MECOM_uc010hwk.1_Missense_Mutation_p.D287Y|MECOM_uc003ffj.3_Missense_Mutation_p.D329Y|MECOM_uc011bpi.1_Missense_Mutation_p.D265Y|MECOM_uc003ffn.3_Missense_Mutation_p.D264Y|MECOM_uc003ffk.2_Missense_Mutation_p.D264Y|MECOM_uc003ffl.2_Missense_Mutation_p.D424Y|MECOM_uc011bpj.1_Missense_Mutation_p.D452Y|MECOM_uc011bpk.1_Missense_Mutation_p.D254Y|MECOM_uc010hwn.2_Missense_Mutation_p.D452Y	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	264					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GACGTTTTATCCATAGCTGGG	0.478													1	0	5.8336e-16	0.003271	6.19057e-16	35	31										A	168834306	C	A	168834306	3	1	117	1	0	0	0	0	1	0	0	0	9422	855	30	3	2405	3	MECOM	3	168834306	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4100544	168834306	29188124	136	35126										
LRRIQ4	344657	broad.mit.edu	37	chr3	169539844	169539844	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccattcctttggagatcttCacattcacagaattagaaga	7	9	3	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:169539844C>T	uc003fgb.2	+	1	135	c.135C>T	c.(133-135)TTC>TTT	p.F45F		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	45	LRR 1.										0						TGGAGATCTTCACATTCACAG	0.398													0	0	0	0.012319	0	15	60										T	169539844	C	T	169539844	2	4	117	1	0	0	0	0	0	0	0	1	9031	825	29	1		1	LRRIQ4	3	169539844	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	705538	169539844	28482586	137	35127										
TBL1XR1	79718	broad.mit.edu	37	chr3	176755921	176755921	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcagaacaggaggccaagaGattgccagttgggtcccatt	13	9	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:176755921G>C	uc003fiw.3	-	12	1347	c.1087C>G	c.(1087-1089)CTC>GTC	p.L363V	TBL1XR1_uc003fix.3_Missense_Mutation_p.L363V|TBL1XR1_uc011bpz.1_Missense_Mutation_p.L35V	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	363	WD 5.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			GAGGCCAAGAGATTGCCAGTT	0.383													0	0	0	0.008361	0	21	23										C	176755921	G	C	176755921	3	2	117	1	0	0	0	0	1	0	0	0	15637	942	33	1	477	1	TBL1XR1	3	176755921	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	7216077	176755921	21266509	138	35128										
USP13	8975	broad.mit.edu	37	chr3	179371085	179371085	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagatggctgcaggagacatCggcgagctgctagtgcccca	14	11	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:179371085C>T	uc003fkh.2	+	1	153	c.72C>T	c.(70-72)ATC>ATT	p.I24I	USP13_uc003fkf.2_Silent_p.I24I	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	24					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			CAGGAGACATCGGCGAGCTGC	0.692													0	0	0	0.000602	0	4	3										T	179371085	C	T	179371085	2	4	117	1	0	0	0	0	0	0	0	1	17041	874	31	1		1	USP13	3	179371085	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2615164	179371085	18651345	139	35129										
CHRD	8646	broad.mit.edu	37	chr3	184099750	184099750	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccctaccaggatccgcttctCagactccaatggcagtgtcc	8	16	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:184099750C>G	uc003fov.2	+	6	887	c.641C>G	c.(640-642)TCA>TGA	p.S214*	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Nonsense_Mutation_p.S214*|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	214	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATCCGCTTCTCAGACTCCAAT	0.527													0	0	0	0.004656	0	22	50										G	184099750	C	G	184099750	4	3	117	1	0	0	0	0	0	1	0	0	3372	838	29	1	663	1	CHRD	3	184099750	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4728665	184099750	13922680	140	35130										
ACAP2	23527	broad.mit.edu	37	chr3	195063325	195063325	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	attttttactaacgcattttCtttttcttcactgacttttt	2	8	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:195063325C>G	uc003fun.3	-	6	644	c.403G>C	c.(403-405)GAA>CAA	p.E135Q	ACAP2_uc003fuo.2_Missense_Mutation_p.E135Q	NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	135	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AACGCATTTTCTTTTTCTTCA	0.328													0	0	0	0.001855	0	14	5										G	195063325	C	G	195063325	3	3	117	1	0	0	0	0	1	0	0	0	119	922	32	1	2005	1	ACAP2	3	195063325	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	10963575	195063325	2959105	141	35131										
TFRC	7037	broad.mit.edu	37	chr3	195780393	195780393	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcacggaagaagtctccacGagcagaatacagccactgta	10	11	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr3:195780393G>A	uc003fvz.3	-	18	2219	c.1936C>T	c.(1936-1938)CGT>TGT	p.R646C	TFRC_uc003fwa.3_Missense_Mutation_p.R646C|TFRC_uc010hzy.2_Missense_Mutation_p.R565C|TFRC_uc011btr.1_Missense_Mutation_p.R364C	NM_003234	NP_003225	P02786	TFR1_HUMAN	transferrin receptor	646	Cell attachment site; required for binding to transferrin.|Extracellular (Potential).|Ligand-binding.			R->A,H: No binding to transferrin.|R->K: 5% binding to transferrin.	cellular iron ion homeostasis|endocytosis|interspecies interaction between organisms|proteolysis|transferrin transport|transmembrane transport	coated pit|endosome|integral to plasma membrane|melanosome	peptidase activity|transferrin receptor activity			ovary(3)	3	all_cancers(143;1.94e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.36e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.17e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00233)		AAGTCTCCACGAGCAGAATAC	0.403			T	BCL6	NHL								0	0	0	0.00361	0	68	59										A	195780393	G	A	195780393	3	1	117	1	0	0	0	0	1	0	0	0	15809	1058	37	1	354	1	TFRC	3	195780393	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	717068	195780393	2242037	142	35132										
GAK	2580	broad.mit.edu	37	chr4	844837	844837	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccttgattggacaacagatCttcaaagtcgttctcagaga	9	9	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:844837C>G	uc003gbm.3	-	26	3743	c.3544G>C	c.(3544-3546)GAT>CAT	p.D1182H	GAK_uc003gbn.3_Missense_Mutation_p.D1103H|GAK_uc003gbk.3_Intron|GAK_uc010ibi.2_Missense_Mutation_p.D407H|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.D1035H	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	1182					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GACAACAGATCTTCAAAGTCG	0.363													0	0	0	0.012319	0	19	49										G	844837	C	G	844837	3	3	117	1	0	0	0	0	1	0	0	0	6195	913	32	1	403	1	GAK	4	844837	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		844837	190309439	143	35133										
POLN	353497	broad.mit.edu	37	chr4	2172884	2172884	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcctgcaacaaaatgagcttCttgctccaattccttgagac	6	12	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:2172884C>G	uc003ger.2	-	10	1399	c.1399G>C	c.(1399-1401)GAA>CAA	p.E467Q	POLN_uc010ich.1_Missense_Mutation_p.E58Q|POLN_uc011bvi.1_Missense_Mutation_p.E467Q	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	467					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			AAATGAGCTTCTTGCTCCAAT	0.323								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.00874	0	34	18										G	2172884	C	G	2172884	3	3	117	1	0	0	0	0	1	0	0	0	12207	922	32	1	1363	1	POLN	4	2172884	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1328047	2172884	188981392	144	35134										
OTOP1	133060	broad.mit.edu	37	chr4	4199382	4199382	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccgaggcagtgcccaccaaGaggtccgagtccagtttgcg	13	14	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:4199382G>A	uc003ghp.1	-	5	1209	c.1179C>T	c.(1177-1179)CTC>CTT	p.L393L		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	393	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGCCCACCAAGAGGTCCGAGT	0.597													0	0	0	0.00361	0	55	62										A	4199382	G	A	4199382	2	1	117	1	0	0	0	0	0	0	0	1	11305	929	33	1		1	OTOP1	4	4199382	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2026498	4199382	186954894	145	35135										
TBC1D1	23216	broad.mit.edu	37	chr4	38138896	38138896	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtggaggagctgcggcggcgGagcgcagagcccagcgaccg	20	12	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:38138896G>A	uc003gtb.2	+	20	3790	c.3447G>A	c.(3445-3447)CGG>CGA	p.R1149R	TBC1D1_uc011byd.1_Silent_p.R1140R|TBC1D1_uc010ifd.2_Silent_p.R936R|TBC1D1_uc003gtd.2_Silent_p.R161R	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1149						nucleus	Rab GTPase activator activity			ovary(1)	1						TGCGGCGGCGGAGCGCAGAGC	0.647													0	0	0	0.004007	0	16	193										A	38138896	G	A	38138896	2	1	117	1	0	0	0	0	0	0	0	1	15594	1161	41	1		1	TBC1D1	4	38138896	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	33939514	38138896	153015380	146	35136										
N4BP2	55728	broad.mit.edu	37	chr4	40104488	40104488	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccaactaaggggaaggatgtGagttactgcccggtacttgc	13	9	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:40104488G>A	uc003guy.3	+	4	1361	c.1023G>A	c.(1021-1023)GTG>GTA	p.V341V	N4BP2_uc010ifq.2_Silent_p.V261V|N4BP2_uc010ifr.2_Silent_p.V261V	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	341	Pro-rich.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GGAAGGATGTGAGTTACTGCC	0.502													0	0	0	0.00333	0	21	37										A	40104488	G	A	40104488	2	1	117	1	0	0	0	0	0	0	0	1	10110	1277	45	1		1	N4BP2	4	40104488	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1965592	40104488	151049788	147	35137										
LPHN3	23284	broad.mit.edu	37	chr4	62849139	62849139	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctgccctgttacatttcttCttcttggctgccttcacctg	7	14	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:62849139C>T	uc010ihh.2	+	16	3023	c.2850C>T	c.(2848-2850)TTC>TTT	p.F950F	LPHN3_uc003hcq.3_Silent_p.F950F|LPHN3_uc003hct.2_Silent_p.F343F	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	937	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TACATTTCTTCTTCTTGGCTG	0.438													0	0	0	0.001855	0	10	18										T	62849139	C	T	62849139	2	4	117	1	0	0	0	0	0	0	0	1	8917	912	32	1		1	LPHN3	4	62849139	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	22744651	62849139	128305137	148	35138										
FRAS1	80144	broad.mit.edu	37	chr4	79437102	79437102	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agagctgcgtgtggacctttGatgcttattatgacatgact	11	7	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:79437102G>A	uc003hlb.2	+	66	10764	c.10324G>A	c.(10324-10326)GAT>AAT	p.D3442N		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3437	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GTGGACCTTTGATGCTTATTA	0.557													0	0	0	0.008291	0	11	27										A	79437102	G	A	79437102	3	1	117	1	0	0	0	0	1	0	0	0	6042	1290	45	1	10661	1	FRAS1	4	79437102	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	16587963	79437102	111717174	149	35139										
WDFY3	23001	broad.mit.edu	37	chr4	85741262	85741262	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atttgtgtttgatccttgaaGaagcactgtcaaggtctcca	9	8	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:85741262G>A	uc003hpd.2	-	12	2077	c.1669C>T	c.(1669-1671)CTT>TTT	p.L557F	WDFY3_uc003hpf.2_Missense_Mutation_p.L557F	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	557						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GATCCTTGAAGAAGCACTGTC	0.378													0	0	0	0.011902	0	35	145										A	85741262	G	A	85741262	3	1	117	1	0	0	0	0	1	0	0	0	17267	942	33	1	9182	1	WDFY3	4	85741262	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6304160	85741262	105413014	150	35140										
MMRN1	22915	broad.mit.edu	37	chr4	90857267	90857267	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttgcaggtattcccagagaTgagaaactaaatcagtccaa	8	9	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:90857267T>C	uc003hst.2	+	6	2507	c.2436T>C	c.(2434-2436)GAT>GAC	p.D812D	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Silent_p.D554D	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	812					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTCCCAGAGATGAGAAACTAA	0.383													0	0	0	0.010729	0	9	30										C	90857267	T	C	90857267	2	2	117	1	0	0	0	0	0	0	0	1	9670	1461	51	5		5	MMRN1	4	90857267	Silent	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	5116005	90857267	100297009	151	35141										
RAP1GDS1	5910	broad.mit.edu	37	chr4	99325699	99325699	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aactcttcaagaaacaaataGaacatgataagagagaaatg	7	5	2	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:99325699G>C	uc003htx.3	+	7	899	c.709G>C	c.(709-711)GAA>CAA	p.E237Q	RAP1GDS1_uc003htw.3_Missense_Mutation_p.E238Q|RAP1GDS1_uc003htv.3_Missense_Mutation_p.E238Q|RAP1GDS1_uc003htz.3_Missense_Mutation_p.E188Q|RAP1GDS1_uc003hty.3_Missense_Mutation_p.E189Q|RAP1GDS1_uc003hua.3_Missense_Mutation_p.E146Q	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	237							binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GAAACAAATAGAACATGATAA	0.318			T	NUP98	T-ALL								0	0	0	0.004482	0	9	25										C	99325699	G	C	99325699	3	2	117	1	0	0	0	0	1	0	0	0	13039	943	33	1	738	1	RAP1GDS1	4	99325699	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8468432	99325699	91828577	152	35142										
ANK2	287	broad.mit.edu	37	chr4	114278820	114278820	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acagtgtctcttcatctttcGagcctactatgtccgctaca	6	13	3	0	rs149963885	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:114278820G>A	uc003ibe.3	+	38	9146	c.9046G>A	c.(9046-9048)GAG>AAG	p.E3016K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.E318K|ANK2_uc011cgb.1_Missense_Mutation_p.E3031K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2983					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCATCTTTCGAGCCTACTAT	0.398													0	0	0	0.00361	0	42	76										A	114278820	G	A	114278820	3	1	117	1	0	0	0	0	1	0	0	0	621	1059	37	1	9261	1	ANK2	4	114278820	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	14953121	114278820	76875456	153	35143										
SYNPO2	171024	broad.mit.edu	37	chr4	119951529	119951529	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	accgatggcctgagaaccacGacttcttaccaaagaaagga	9	11	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:119951529G>A	uc003icm.3	+	4	1795	c.1599G>A	c.(1597-1599)ACG>ACA	p.T533T	SYNPO2_uc010ina.2_Silent_p.T533T|SYNPO2_uc010inb.2_Silent_p.T533T|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Silent_p.T461T	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	533						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TGAGAACCACGACTTCTTACC	0.507													0	0	0	0.003954	0	23	20										A	119951529	G	A	119951529	2	1	117	1	0	0	0	0	0	0	0	1	15454	1045	37	1		1	SYNPO2	4	119951529	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5672709	119951529	71202747	154	35144										
MORF4	10934	broad.mit.edu	37	chr4	174537213	174537213	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttgagtaataaagcaaggctCttctcattcagaggtgtata	9	6	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr4:174537213C>G	uc011cke.1	-	1	582	c.582G>C	c.(580-582)AAG>AAC	p.K194N		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AAGCAAGGCTCTTCTCATTCA	0.438													0	0	0	0.007291	0	25	46										G	174537213	C	G	174537213	3	3	117	1	0	0	0	0	1	0	0	0	9705	912	32	1	128	1	MORF4	4	174537213	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	54585684	174537213	16617063	155	35145										
ADAMTS16	170690	broad.mit.edu	37	chr5	5239991	5239991	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gacggtcctataatgagcccGagaacttaatcgctactgga	10	10	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:5239991G>A	uc003jdl.2	+	16	2614	c.2476G>A	c.(2476-2478)GAG>AAG	p.E826K	ADAMTS16_uc003jdk.1_Missense_Mutation_p.E826K	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	826	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TAATGAGCCCGAGAACTTAAT	0.517													0	0	0	0.009535	0	27	118										A	5239991	G	A	5239991	3	1	117	1	0	0	0	0	1	0	0	0	261	1059	37	1	2538	1	ADAMTS16	5	5239991	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		5239991	175675269	156	35146										
KIAA0947	23379	broad.mit.edu	37	chr5	5460802	5460802	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacagcaacactgagagaatCttctgccacacactccttag	6	14	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:5460802C>T	uc003jdm.3	+	13	1577	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	452										ovary(1)|central_nervous_system(1)	2						CTGAGAGAATCTTCTGCCACA	0.408													0	0	0	0.006214	0	7	27										T	5460802	C	T	5460802	3	4	117	1	0	0	0	0	1	0	0	0	8202	913	32	1	1405	1	KIAA0947	5	5460802	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	220811	5460802	175454458	157	35147										
RICTOR	253260	broad.mit.edu	37	chr5	38947495	38947495	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtattttgattaataggactCaataaatcttctttatctaa	4	5	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:38947495C>T	uc003jlp.2	-	32	4209	c.4185G>A	c.(4183-4185)TTG>TTA	p.L1395L	RICTOR_uc003jlo.2_Silent_p.L1419L|RICTOR_uc010ivf.2_Silent_p.L1110L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1395					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding	p.L1395L(1)		ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TAATAGGACTCAATAAATCTT	0.373													0	0	0	0.010818	0	34	30										T	38947495	C	T	38947495	2	4	117	1	0	0	0	0	0	0	0	1	13358	825	29	1		1	RICTOR	5	38947495	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	33486693	38947495	141967765	158	35148										
MAP1B	4131	broad.mit.edu	37	chr5	71494799	71494799	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgactttagctatgcctatCaaaagcctgaggaaacaacc	8	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:71494799C>T	uc003kbw.3	+	5	5858	c.5617C>T	c.(5617-5619)CAA>TAA	p.Q1873*	MAP1B_uc010iyw.1_Nonsense_Mutation_p.Q1890*|MAP1B_uc010iyx.1_Nonsense_Mutation_p.Q1747*|MAP1B_uc010iyy.1_Nonsense_Mutation_p.Q1747*	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1873						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTATGCCTATCAAAAGCCTGA	0.473													0	0	0	0.010818	0	29	7										T	71494799	C	T	71494799	4	4	117	1	0	0	0	0	0	1	0	0	9228	827	29	1	5635	1	MAP1B	5	71494799	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	32547304	71494799	109420461	159	35149										
CHD1	1105	broad.mit.edu	37	chr5	98236691	98236691	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcgacgagaacttcttttaTcattatcataatcttcttca	5	9	6	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:98236691T>C	uc003knf.2	-	6	831	c.683A>G	c.(682-684)GAT>GGT	p.D228G		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	228					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ACTTCTTTTATCATTATCATA	0.363													0	0	0	0.00499	0	15	20										C	98236691	T	C	98236691	3	2	117	1	0	0	0	0	1	0	0	0	3323	1435	50	5	4569	5	CHD1	5	98236691	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	26741892	98236691	82678569	160	35150										
PPP2CA	5515	broad.mit.edu	37	chr5	133536147	133536147	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gagatataccccaaccaccaCggtcatctggatctgaccac	7	15	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:133536147C>T	uc003kze.2	-	5	1015	c.617G>A	c.(616-618)CGT>CAT	p.R206H		NM_002715	NP_002706	P67775	PP2AA_HUMAN	protein phosphatase 2, catalytic subunit, alpha	206					ceramide metabolic process|inactivation of MAPK activity|induction of apoptosis|meiosis|negative regulation of cell growth|negative regulation of epithelial to mesenchymal transition|negative regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of protein serine/threonine kinase activity|protein dephosphorylation|regulation of cell adhesion|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction|spindle pole	metal ion binding|phosphoprotein phosphatase activity			ovary(2)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Vitamin E(DB00163)	CCAACCACCACGGTCATCTGG	0.413													0	0	0	0.00874	0	36	12										T	133536147	C	T	133536147	3	4	117	1	0	0	0	0	1	0	0	0	12380	536	19	2	324	2	PPP2CA	5	133536147	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	35299456	133536147	47379113	161	35151										
PURA	5813	broad.mit.edu	37	chr5	139494256	139494256	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggatctcaaggagaaccagCgcggccgcttcctgcgcatc	12	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:139494256C>T	uc003lfa.2	+	1	549	c.490C>T	c.(490-492)CGC>TGC	p.R164C		NM_005859	NP_005850	Q00577	PURA_HUMAN	purine-rich element binding protein A	164					DNA unwinding involved in replication|DNA-dependent DNA replication initiation	DNA replication factor A complex	double-stranded telomeric DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|single-stranded DNA binding|transcription factor binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAACCAGCGCGGCCGCTT	0.692													0	0	0	0.001855	0	11	30										T	139494256	C	T	139494256	3	4	117	1	0	0	0	0	1	0	0	0	12827	768	27	2	492	2	PURA	5	139494256	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5958109	139494256	41421004	162	35152										
WDR55	54853	broad.mit.edu	37	chr5	140048746	140048746	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttggggccacaagtgaccGctttgccctgagagctgaat	12	11	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140048746G>A	uc003lgr.3	+	6	857	c.743G>A	c.(742-744)CGC>CAC	p.R248H	WDR55_uc011czl.1_Missense_Mutation_p.R87H	NM_017706	NP_060176	Q9H6Y2	WDR55_HUMAN	WD repeat domain 55	248					rRNA processing	cytoplasm|nucleolus				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAGTGACCGCTTTGCCCTG	0.532													0	0	0	0.00308	0	8	72										A	140048746	G	A	140048746	3	1	117	1	0	0	0	0	1	0	0	0	17304	1087	38	2	765	2	WDR55	5	140048746	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	554490	140048746	40866514	163	35153										
PCDHA2	56146	broad.mit.edu	37	chr5	140175513	140175513	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctacgagattcaggtcactGcaactgacaaaggaacccct	8	13	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140175513G>A	uc003lhd.2	+	1	1070	c.964G>A	c.(964-966)GCA>ACA	p.A322T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A322T|PCDHA2_uc011czy.1_Missense_Mutation_p.A322T	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	322	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGGTCACTGCAACTGACAA	0.378													0	0	0	0.010729	0	12	35										A	140175513	G	A	140175513	3	1	117	1	0	0	0	0	1	0	0	0	11524	1319	46	2	966	2	PCDHA2	5	140175513	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	126767	140175513	40739747	164	35154										
PCDHB16	57717	broad.mit.edu	37	chr5	140563916	140563916	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaggtggtggcggtggacggCgactcgggccagaatgcctg	19	9	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140563916C>T	uc003liv.2	+	1	2937	c.1782C>T	c.(1780-1782)GGC>GGT	p.G594G	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	594	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGTGGACGGCGACTCGGGCC	0.706													0	0	0	0.001168	0	4	52										T	140563916	C	T	140563916	2	4	117	1	0	0	0	0	0	0	0	1	11541	755	27	2		2	PCDHB16	5	140563916	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	388403	140563916	40351344	165	35155										
PCDHB9	56127	broad.mit.edu	37	chr5	140569002	140569002	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcttcgctcttcctcctctCggtgctcctgttcgtggcgg	11	15	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140569002C>T	uc003liw.1	+	3	2111	c.2111C>T	c.(2110-2112)TCG>TTG	p.S704L	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	704	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCCTCCTCTCGGTGCTCCTG	0.701													0	0	0	0.00361	0	99	204										T	140569002	C	T	140569002	3	4	117	1	0	0	0	0	1	0	0	0	11549	875	31	1	2112	1	PCDHB9	5	140569002	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5086	140569002	40346258	166	35156										
PCDHGB5	56101	broad.mit.edu	37	chr5	140779598	140779598	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gggcgacagggacgcggcccGccagcgcctgctggttgctg	18	14	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140779598G>A	uc003lkf.1	+	1	1904	c.1904G>A	c.(1903-1905)CGC>CAC	p.R635H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.R635H|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	635	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCGGCCCGCCAGCGCCTG	0.687													0	0	0	0.00245	0	15	29										A	140779598	G	A	140779598	3	1	117	1	0	0	0	0	1	0	0	0	11566	1087	38	2	1906	2	PCDHGB5	5	140779598	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	210596	140779598	40135662	167	35157										
DIAPH1	1729	broad.mit.edu	37	chr5	140953172	140953172	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaatccaaatgggggaggtgGaggcatacccattccgggtg	15	8	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:140953172G>A	uc003llb.3	-	16	2386	c.2245C>T	c.(2245-2247)CCA>TCA	p.P749S	DIAPH1_uc003llc.3_Missense_Mutation_p.P740S|DIAPH1_uc010jgc.1_Missense_Mutation_p.P188S	NM_005219	NP_005210	O60610	DIAP1_HUMAN	diaphanous 1 isoform 1	749	FH1.				regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGGAGGTGGAGGCATACCC	0.587													0	0	0	0.003163	0	14	34										A	140953172	G	A	140953172	3	1	117	1	0	0	0	0	1	0	0	0	4518	1174	41	1	1625	1	DIAPH1	5	140953172	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	173574	140953172	39962088	168	35158										
ARHGAP26	23092	broad.mit.edu	37	chr5	142435652	142435652	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagtttcatcaaagcagcaaGtaagtcttttttgtctcagt	7	7	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:142435652G>T	uc011dbj.1	+	16	1467	c.1432_splice	c.e16+1	p.K478_splice	ARHGAP26_uc003lmt.2_Splice_Site_p.K478_splice|ARHGAP26_uc003lmw.2_Splice_Site_p.K478_splice	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal						actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAGCAGCAAGTAAGTCTTTT	0.353													1	0	2.05212e-20	0.005524	2.21333e-20	33	55										T	142435652	G	T	142435652	5	4	117	1	0	0	0	0	0	0	1	0	875	1043	36	4	1495	4	ARHGAP26	5	142435652	Splice_Site	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1482480	142435652	38479608	169	35159										
ARSI	340075	broad.mit.edu	37	chr5	149676860	149676860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttgcattttttcttgcgacGaccccgggagaagcttcgag	11	11	1	1	rs142267983		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:149676860G>A	uc003lrv.2	-	2	2216	c.1627C>T	c.(1627-1629)CGT>TGT	p.R543C		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	543						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTTGCGACGACCCCGGGAG	0.547													0	0	0	0.00361	0	42	96										A	149676860	G	A	149676860	3	1	117	1	0	0	0	0	1	0	0	0	994	1058	37	1	86	1	ARSI	5	149676860	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	7241208	149676860	31238400	170	35160										
ODZ2	57451	broad.mit.edu	37	chr5	167642220	167642220	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcagtgtctaccctttgatGaagcccgctgcggggatgga	14	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:167642220G>A	uc010jjd.2	+	21	3994	c.3994G>A	c.(3994-3996)GAA>AAA	p.E1332K	ODZ2_uc003lzr.3_Missense_Mutation_p.E1102K|ODZ2_uc003lzt.3_Missense_Mutation_p.E705K|ODZ2_uc010jje.2_Missense_Mutation_p.E596K	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACCCTTTGATGAAGCCCGCTG	0.557													0	0	0	0.00361	0	105	23										A	167642220	G	A	167642220	3	1	117	1	0	0	0	0	1	0	0	0	10835	1291	45	1	4076	1	ODZ2	5	167642220	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	17965360	167642220	13273040	171	35161										
RANBP17	64901	broad.mit.edu	37	chr5	170319554	170319554	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctgatgtgaagaagtttctCcaggtaagaagtcattgcta	11	6	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:170319554C>G	uc003mba.2	+	4	436	c.420C>G	c.(418-420)CTC>CTG	p.L140L	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA|RANBP17_uc003maw.2_Silent_p.L140L|RANBP17_uc011dew.1_Silent_p.L140L	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	140					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGAAGTTTCTCCAGGTAAGAA	0.348			T	TRD@	ALL								0	0	0	0.009535	0	25	69										G	170319554	C	G	170319554	2	3	117	1	0	0	0	0	0	0	0	1	13027	842	30	1		1	RANBP17	5	170319554	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2677334	170319554	10595706	172	35162										
RANBP17	64901	broad.mit.edu	37	chr5	170610195	170610195	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atccttttaaaaaaacttgtGaagatagatgctgtgaaatt	7	4	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr5:170610195G>A	uc003mba.2	+	17	1906	c.1890G>A	c.(1888-1890)GTG>GTA	p.V630V	RANBP17_uc003mbb.2_Intron|RANBP17_uc003mbd.2_5'UTR|RANBP17_uc010jjs.2_RNA|RANBP17_uc003mbc.2_5'UTR	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	630					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AAAAACTTGTGAAGATAGATG	0.264			T	TRD@	ALL								0	0	0	0.002299	0	18	1										A	170610195	G	A	170610195	2	1	117	1	0	0	0	0	0	0	0	1	13027	1277	45	1		1	RANBP17	5	170610195	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	290641	170610195	10305065	173	35163										
BMP6	654	broad.mit.edu	37	chr6	7727603	7727603	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgcccctcttcatgctggatCtgtacaacgccctgtccgcc	8	18	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:7727603C>T	uc003mxu.3	+	1	593	c.415C>T	c.(415-417)CTG>TTG	p.L139L		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	139					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CATGCTGGATCTGTACAACGC	0.597													0	0	0	0.012319	0	19	55										T	7727603	C	T	7727603	2	4	117	1	0	0	0	0	0	0	0	1	1464	912	32	1		1	BMP6	6	7727603	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		7727603	163387464	174	35164										
BMP6	654	broad.mit.edu	37	chr6	7727750	7727750	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgctcaaccgcaagagccttCtggcccccggatctggcagc	11	17	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:7727750C>T	uc003mxu.3	+	1	740	c.562C>T	c.(562-564)CTG>TTG	p.L188L		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	188					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CAAGAGCCTTCTGGCCCCCGG	0.711													0	0	0	0.004007	0	13	23										T	7727750	C	T	7727750	2	4	117	1	0	0	0	0	0	0	0	1	1464	912	32	1		1	BMP6	6	7727750	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	147	7727750	163387317	175	35165										
TXNDC5	81567	broad.mit.edu	37	chr6	7891866	7891866	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcactcaccttgccaatcttGacagtttcggaatgttcaag	7	11	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:7891866G>A	uc003mxv.2	-	5	752	c.720C>T	c.(718-720)GTC>GTT	p.V240V	TXNDC5_uc003mxw.2_Silent_p.V197V|TXNDC5_uc010jnz.2_Silent_p.V132V|TXNDC5_uc010joa.1_Silent_p.V132V	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	240	Thioredoxin 2.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					TGCCAATCTTGACAGTTTCGG	0.493													0	0	0	0.00623	0	35	128										A	7891866	G	A	7891866	2	1	117	1	0	0	0	0	0	0	0	1	16796	1277	45	1		1	TXNDC5	6	7891866	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	164116	7891866	163223201	176	35166										
RANBP9	10048	broad.mit.edu	37	chr6	13711709	13711709	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctgctgttgctgctgctgcGgcggcggcggcggcggctgc	20	13	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:13711709G>T	uc003nbb.2	-	1	88	c.29C>A	c.(28-30)CCG>CAG	p.P10Q		NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	10	Poly-Pro.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ctgctgctgcggcggcggcgg	0.517													1	0	0.00448238	0.004482	0.00453746	8	69										T	13711709	G	T	13711709	3	4	117	1	0	0	0	0	1	0	0	0	13032	1116	39	4	2216	4	RANBP9	6	13711709	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5819843	13711709	157403358	177	35167										
SOX4	6659	broad.mit.edu	37	chr6	21595158	21595158	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gactacaagtaccggcccagGaagaaggtgaagtccggcaa	13	10	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:21595158G>T	uc003ndi.2	+	1	1187	c.393G>T	c.(391-393)AGG>AGT	p.R131S		NM_003107	NP_003098	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	131					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity				0	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			ACCGGCCCAGGAAGAAGGTGA	0.557													1	0	2.0095e-06	0.001984	2.06271e-06	5	215										T	21595158	G	T	21595158	3	4	117	1	0	0	0	0	1	0	0	0	14953	1165	41	3	395	3	SOX4	6	21595158	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	7883449	21595158	149519909	178	35168										
NRSN1	140767	broad.mit.edu	37	chr6	24145869	24145869	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccaaaatcgaagcatttggcGaagccgattttgtggtggtc	12	8	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:24145869G>A	uc010jpq.1	+	4	520	c.283G>A	c.(283-285)GAA>AAA	p.E95K		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	95					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						AGCATTTGGCGAAGCCGATTT	0.507													0	0	0	0.00361	0	47	208										A	24145869	G	A	24145869	3	1	117	1	0	0	0	0	1	0	0	0	10662	1059	37	1	289	1	NRSN1	6	24145869	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2550711	24145869	146969198	179	35169										
HIST1H2BE	8344	broad.mit.edu	37	chr6	26184245	26184245	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacgacatcttcgagcgcatCgccggcgaggcttcccgcct	11	16	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:26184245C>T	uc003ngt.2	+	1	222	c.222C>T	c.(220-222)ATC>ATT	p.I74I		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	74					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						TCGAGCGCATCGCCGGCGAGG	0.607													0	0	0	0.00361	0	292	26										T	26184245	C	T	26184245	2	4	117	1	0	0	0	0	0	0	0	1	7144	874	31	1		1	HIST1H2BE	6	26184245	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2038376	26184245	144930822	180	35170										
BTN3A1	11119	broad.mit.edu	37	chr6	26408131	26408131	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gagggtgtatcctgtaccatCagaagttccctcctcggcct	10	13	1	1	rs140260146		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:26408131C>G	uc003nhv.2	+	4	1034	c.666C>G	c.(664-666)ATC>ATG	p.I222M	BTN3A1_uc011dkj.1_Missense_Mutation_p.I222M|BTN3A1_uc011dkk.1_Missense_Mutation_p.I170M|BTN3A1_uc010jqj.2_Missense_Mutation_p.I222M	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	222	Ig-like V-type 2.|Extracellular (Potential).				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCTGTACCATCAGAAGTTCCC	0.557													0	0	0	0.00361	0	221	16										G	26408131	C	G	26408131	3	3	117	1	0	0	0	0	1	0	0	0	1562	816	29	1	676	1	BTN3A1	6	26408131	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	223886	26408131	144706936	181	35171										
BTN1A1	696	broad.mit.edu	37	chr6	26505305	26505305	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctacatcagagtccaggaatCctgatgaagaaggtttgttc	10	8	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:26505305C>G	uc003nif.3	+	3	600	c.580C>G	c.(580-582)CCT>GCT	p.P194A		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	194	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						GTCCAGGAATCCTGATGAAGA	0.502													0	0	0	0.00361	0	88	6										G	26505305	C	G	26505305	3	3	117	1	0	0	0	0	1	0	0	0	1559	855	30	1	590	1	BTN1A1	6	26505305	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	97174	26505305	144609762	182	35172										
HIST1H4I	8294	broad.mit.edu	37	chr6	27107240	27107240	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagcgcatttctggcctcatCtatgaggagacccgcggagt	12	11	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:27107240C>G	uc003niy.1	+	1	153	c.153C>G	c.(151-153)ATC>ATG	p.I51M	HIST1H2BK_uc003nix.1_Intron	NM_003495	NP_003486	P62805	H4_HUMAN	histone cluster 1, H4i	51					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						CTGGCCTCATCTATGAGGAGA	0.637			T	BCL6	NHL								0	0	0	0.00361	0	185	141										G	27107240	C	G	27107240	3	3	117	1	0	0	0	0	1	0	0	0	7173	903	32	1	155	1	HIST1H4I	6	27107240	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	601935	27107240	144007827	183	35173										
BAT2	7916	broad.mit.edu	37	chr6	31591626	31591626	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggcaatgaccccaatgtctCactagtgccaaaagacggaa	9	11	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:31591626C>T	uc003nvb.3	+	3	479	c.230C>T	c.(229-231)TCA>TTA	p.S77L	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.S77L|BAT2_uc003nve.2_5'Flank	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	77	4 X 57 AA type A repeats.|1-1.					cytoplasm|nucleus	protein binding				0						CCCAATGTCTCACTAGTGCCA	0.547													0	0	0	0.004656	0	19	89										T	31591626	C	T	31591626	3	4	117	1	0	0	0	0	1	0	0	0	1319	838	29	1	236	1	BAT2	6	31591626	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4484386	31591626	139523441	184	35174										
PHF1	5252	broad.mit.edu	37	chr6	33380128	33380128	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccacctctggccccaggcctCggctttgggagggtcaagat	13	14	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:33380128C>T	uc003oeh.2	+	2	324	c.88C>T	c.(88-90)CGG>TGG	p.R30W	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.R30W|PHF1_uc010jux.2_5'UTR	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	30					chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CCCCAGGCCTCGGCTTTGGGA	0.607													0	0	0	0.002836	0	28	7										T	33380128	C	T	33380128	3	4	117	1	0	0	0	0	1	0	0	0	11820	875	31	1	90	1	PHF1	6	33380128	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1788502	33380128	137734939	185	35175										
FGD2	221472	broad.mit.edu	37	chr6	36982667	36982667	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggatgcaccccaaccccctaGgagcggctgcaggacctgtg	13	15	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:36982667G>A	uc010jwp.1	+	8	1054	c.883_splice	c.e8-1	p.E295_splice	FGD2_uc003ong.2_Splice_Site_p.E17_splice|FGD2_uc011dtv.1_Splice_Site|FGD2_uc003oni.1_Splice_Site_p.E101_splice	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						CAACCCCCTAGGAGCGGCTGC	0.652													0	0	0	0.007291	0	24	292										A	36982667	G	A	36982667	5	1	117	1	0	0	0	0	0	0	1	0	5833	1014	35	2	912	2	FGD2	6	36982667	Splice_Site	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3602539	36982667	134132400	186	35176										
CYP39A1	51302	broad.mit.edu	37	chr6	46593206	46593206	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cataatggccttgtggatatCaggatgagaaaggacgtatg	13	5	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:46593206C>T	uc003oyf.1	-	7	1084	c.880G>A	c.(880-882)GAT>AAT	p.D294N	CYP39A1_uc011dwa.1_Missense_Mutation_p.D274N|CYP39A1_uc010jzd.1_Missense_Mutation_p.D122N	NM_016593	NP_057677	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A,	294					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1						TTGTGGATATCAGGATGAGAA	0.343													0	0	0	0.00361	0	142	112										T	46593206	C	T	46593206	3	4	117	1	0	0	0	0	1	0	0	0	4177	826	29	1	553	1	CYP39A1	6	46593206	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	9610539	46593206	124521861	187	35177										
PLA2G7	7941	broad.mit.edu	37	chr6	46682224	46682224	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccaagaccatgagaaaaaAcaacaagtggatatttttca	6	9	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:46682224A>G	uc010jzf.2	-	5	712	c.443T>C	c.(442-444)GTT>GCT	p.V148A	PLA2G7_uc010jzg.1_Missense_Mutation_p.V148A|PLA2G7_uc011dwd.1_Missense_Mutation_p.V103A|PLA2G7_uc011dwe.1_Missense_Mutation_p.V21A	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	148					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			ATGAGAAAAAACAACAAGTGG	0.368													0	0	0	0.00361	0	58	477										G	46682224	A	G	46682224	3	3	117	1	0	0	0	0	1	0	0	0	12009	43	2	5	914	5	PLA2G7	6	46682224	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	89018	46682224	124432843	188	35178										
KLHL31	401265	broad.mit.edu	37	chr6	53516582	53516582	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tacttcttctcgccctcgttCcagccccccaccaggtaggc	7	19	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:53516582C>T	uc003pcb.3	-	3	1860	c.1719G>A	c.(1717-1719)TGG>TGA	p.W573*	uc003pcc.1_5'UTR	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	573	Kelch 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CGCCCTCGTTCCAGCCCCCCA	0.687													0	0	0	0.004007	0	15	41										T	53516582	C	T	53516582	4	4	117	1	0	0	0	0	0	1	0	0	8385	856	30	1	189	1	KLHL31	6	53516582	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6834358	53516582	117598485	189	35179										
KLHL31	401265	broad.mit.edu	37	chr6	53516760	53516760	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgccgcccatcacgtacactCtgtcgctcagcgtgaccgcg	10	17	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:53516760C>G	uc003pcb.3	-	3	1682	c.1541G>C	c.(1540-1542)AGA>ACA	p.R514T	uc003pcc.1_Missense_Mutation_p.S51C	NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	514					regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					CACGTACACTCTGTCGCTCAG	0.716													0	0	0	0.000602	0	3	10										G	53516760	C	G	53516760	3	3	117	1	0	0	0	0	1	0	0	0	8385	913	32	1	367	1	KLHL31	6	53516760	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	178	53516760	117598307	190	35180										
DST	667	broad.mit.edu	37	chr6	56505039	56505039	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caaagaagactttagaagggGttttcggatctgcatcaact	10	7	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:56505039G>T	uc003pdf.2	-	17	2321	c.2293C>A	c.(2293-2295)CCC>ACC	p.P765T	DST_uc003pcz.3_Missense_Mutation_p.P587T|DST_uc011dxj.1_Missense_Mutation_p.P616T|DST_uc011dxk.1_Missense_Mutation_p.P627T|DST_uc011dxl.1_Missense_Mutation_p.P616T|DST_uc003pcy.3_Missense_Mutation_p.P261T|DST_uc003pdb.2_Missense_Mutation_p.P261T|DST_uc003pdc.3_Missense_Mutation_p.P261T|DST_uc003pdd.3_Missense_Mutation_p.P261T|DST_uc003pde.2_Missense_Mutation_p.P703T	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	587					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTAGAAGGGGTTTTCGGATC	0.368													1	0	8.12818e-05	0.001984	8.31751e-05	7	35										T	56505039	G	T	56505039	3	4	117	1	0	0	0	0	1	0	0	0	4783	1261	44	4	19698	4	DST	6	56505039	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2988279	56505039	114610028	191	35181										
DST	667	broad.mit.edu	37	chr6	56716381	56716381	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agaggaagacatagagcagcGataggacgcgttcccggaac	14	9	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:56716381G>C	uc003pdf.2	-	4	467	c.439C>G	c.(439-441)CGC>GGC	p.R147G	DST_uc011dxj.1_Translation_Start_Site|DST_uc011dxk.1_Missense_Mutation_p.R9G|DST_uc011dxl.1_Translation_Start_Site	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATAGAGCAGCGATAGGACGCG	0.478											OREG0017515	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	6	13										C	56716381	G	C	56716381	3	2	117	1	0	0	0	0	1	0	0	0	4783	1073	37	1		1	DST	6	56716381	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	211342	56716381	114398686	192	35182										
PHF3	23469	broad.mit.edu	37	chr6	64416024	64416024	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcagaaagtatagcagatgCattatcttcaacctcaaata	6	8	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:64416024C>T	uc003pep.1	+	11	3499	c.3473C>T	c.(3472-3474)GCA>GTA	p.A1158V	PHF3_uc010kah.1_Missense_Mutation_p.A972V|PHF3_uc003pen.2_Missense_Mutation_p.A1070V|PHF3_uc011dxs.1_Missense_Mutation_p.A427V	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1158					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			ATAGCAGATGCATTATCTTCA	0.398													0	0	0	0.001368	0	12	27										T	64416024	C	T	64416024	3	4	117	1	0	0	0	0	1	0	0	0	11836	710	25	2	3515	2	PHF3	6	64416024	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7699643	64416024	106699043	193	35183										
BAI3	577	broad.mit.edu	37	chr6	70034888	70034888	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aattaggacacggcttataaGaaaacgctttttgtgccttg	9	7	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:70034888G>A	uc003pev.3	+	21	3387	c.2939G>A	c.(2938-2940)AGA>AAA	p.R980K	BAI3_uc010kak.2_Missense_Mutation_p.R980K|BAI3_uc011dxx.1_Missense_Mutation_p.R186K|BAI3_uc003pex.1_Missense_Mutation_p.R110K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	980	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CGGCTTATAAGAAAACGCTTT	0.398													0	0	0	0.008871	0	17	50										A	70034888	G	A	70034888	3	1	117	1	0	0	0	0	1	0	0	0	1300	942	33	1	3013	1	BAI3	6	70034888	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5618864	70034888	101080179	194	35184										
KCNQ5	56479	broad.mit.edu	37	chr6	73904395	73904395	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aactagtgccaacatctcgaGaggcctgcagttcattctga	9	11	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:73904395G>A	uc003pgk.2	+	14	2404	c.2057G>A	c.(2056-2058)AGA>AAA	p.R686K	KCNQ5_uc011dyh.1_Missense_Mutation_p.R705K|KCNQ5_uc011dyi.1_Missense_Mutation_p.R696K|KCNQ5_uc010kat.2_Missense_Mutation_p.R677K|KCNQ5_uc011dyj.1_Missense_Mutation_p.R576K|KCNQ5_uc011dyk.1_Missense_Mutation_p.R436K	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	686					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AACATCTCGAGAGGCCTGCAG	0.488													0	0	0	0.00361	0	71	70										A	73904395	G	A	73904395	3	1	117	1	0	0	0	0	1	0	0	0	8086	942	33	1	2172	1	KCNQ5	6	73904395	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3869507	73904395	97210672	195	35185										
DDX43	55510	broad.mit.edu	37	chr6	74119057	74119057	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gatgtgcgcccagataggcaGacagttatgaccaggtacgt	13	9	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:74119057G>A	uc003pgw.2	+	10	1610	c.1266G>A	c.(1264-1266)CAG>CAA	p.Q422Q		NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	422	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						CAGATAGGCAGACAGTTATGA	0.383													0	0	0	0.00361	0	47	138										A	74119057	G	A	74119057	2	1	117	1	0	0	0	0	0	0	0	1	4363	933	33	1		1	DDX43	6	74119057	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	214662	74119057	96996010	196	35186										
LCA5	167691	broad.mit.edu	37	chr6	80223183	80223183	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaatataagttgtgagatttCattttcggcatcttcaaact	6	6	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:80223183C>T	uc003pix.2	-	3	901	c.466G>A	c.(466-468)GAA>AAA	p.E156K	LCA5_uc003piy.2_Missense_Mutation_p.E156K|LCA5_uc011dyq.1_RNA|LCA5_uc011dyr.1_Missense_Mutation_p.E156K	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	156	Potential.				protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TGTGAGATTTCATTTTCGGCA	0.378													0	0	0	0.012319	0	18	16										T	80223183	C	T	80223183	3	4	117	1	0	0	0	0	1	0	0	0	8656	835	29	1	1651	1	LCA5	6	80223183	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6104126	80223183	90891884	197	35187										
SLC35A1	10559	broad.mit.edu	37	chr6	88210332	88210332	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catcgttagtgtatgctgttCagaacaacatggctttccta	8	9	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:88210332C>G	uc011dzj.1	+	3	380	c.301C>G	c.(301-303)CAG>GAG	p.Q101E	SLC35A1_uc003plx.2_RNA|SLC35A1_uc010kbw.2_5'UTR|SLC35A1_uc003plz.2_Intron|SLC35A1_uc011dzi.1_Intron|SLC35A1_uc003ply.2_RNA|SLC35A1_uc010kbx.2_Missense_Mutation_p.Q101E|SLC35A1_uc010kby.2_RNA	NM_006416	NP_006407	P78382	S35A1_HUMAN	solute carrier family 35 (CMP-sialic acid	101	Helical; (Potential).				carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GTATGCTGTTCAGAACAACAT	0.413													0	0	0	0.004289	0	30	23										G	88210332	C	G	88210332	3	3	117	1	0	0	0	0	1	0	0	0	14570	827	29	1	311	1	SLC35A1	6	88210332	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7987149	88210332	82904735	198	35188										
RARS2	57038	broad.mit.edu	37	chr6	88299660	88299660	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctggcaagcaatagcgcggcGaaagccgcacgccatgtcca	12	14	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:88299660G>A	uc003pme.2	-	1	76	c.16C>T	c.(16-18)CGC>TGC	p.R6C	ORC3L_uc011dzl.1_5'Flank|ORC3L_uc011dzm.1_5'Flank|ORC3L_uc011dzn.1_5'Flank|ORC3L_uc003pmg.2_5'Flank|ORC3L_uc003pmh.2_5'Flank|ORC3L_uc003pmi.2_5'Flank|ORC3L_uc011dzo.1_5'Flank|ORC3L_uc011dzp.1_5'Flank|RARS2_uc003pmb.2_5'UTR|RARS2_uc003pmc.2_5'UTR|RARS2_uc003pmd.2_5'UTR|RARS2_uc003pmf.2_RNA	NM_020320	NP_064716	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	6					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		ATAGCGCGGCGAAAGCCGCAC	0.672											OREG0031911	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.00361	0	45	25										A	88299660	G	A	88299660	3	1	117	1	0	0	0	0	1	0	0	0	13059	1058	37	1	1800	1	RARS2	6	88299660	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	89328	88299660	82815407	199	35189										
GJA10	84694	broad.mit.edu	37	chr6	90605283	90605283	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcctgcagaatacaatgtctCagtcctggctaggtacaact	9	11	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:90605283C>G	uc011eaa.1	+	1	1096	c.1096C>G	c.(1096-1098)CAG>GAG	p.Q366E		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	366	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TACAATGTCTCAGTCCTGGCT	0.552													0	0	0	0.00361	0	95	65										G	90605283	C	G	90605283	3	3	117	1	0	0	0	0	1	0	0	0	6401	827	29	1	1098	1	GJA10	6	90605283	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2305623	90605283	80509784	200	35190										
BACH2	60468	broad.mit.edu	37	chr6	90661329	90661329	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atccatcgtctcctcctcttCatcctcctcctctcctgcag	3	20	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:90661329C>T	uc011eab.1	-	7	1305	c.496G>A	c.(496-498)GAA>AAA	p.E166K	BACH2_uc003pnw.2_Missense_Mutation_p.E166K|BACH2_uc010kch.2_Missense_Mutation_p.E166K	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	166	Poly-Glu.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TCCTCCTCTTCATCCTCCTCC	0.612													0	0	0	0.00361	0	57	41										T	90661329	C	T	90661329	3	4	117	1	0	0	0	0	1	0	0	0	1284	835	29	1	2041	1	BACH2	6	90661329	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	56046	90661329	80453738	201	35191										
ZBTB24	9841	broad.mit.edu	37	chr6	109802504	109802504	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttgcctggccatcctcggtCttgggatcatagttctcatc	9	13	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:109802504C>G	uc003ptl.1	-	2	894	c.726G>C	c.(724-726)AAG>AAC	p.K242N	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.K242N|ZBTB24_uc010kdt.1_RNA|ZBTB24_uc003ptm.2_Missense_Mutation_p.K242N	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		CATCCTCGGTCTTGGGATCAT	0.463													0	0	0	0.00361	0	55	104										G	109802504	C	G	109802504	3	3	117	1	0	0	0	0	1	0	0	0	17528	912	32	1	1441	1	ZBTB24	6	109802504	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	19141175	109802504	61312563	202	35192										
TUBE1	51175	broad.mit.edu	37	chr6	112400898	112400898	+	Missense_Mutation	SNP	C	C	T													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacagtgctctgccgactttCtgaatttctctaaaatctgg							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:112400898C>T	uc003pvq.2	-	6	500	c.386G>A	c.(385-387)AGA>AAA	p.R129K	TUBE1_uc003pvr.2_Missense_Mutation_p.R54K	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	129					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TGCCGACTTTCTGAATTTCTC	0.368													0	0	0	0.012319	0	20	28										T	112400898	C	T	112400898	3	4	117	1	0	0	0	0	1	0	0	0	16760	913	32	1	1069	1	TUBE1	6	112400898	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2598394	112400898	58714169	203	35193	181	2								
TUBE1	51175	broad.mit.edu	37	chr6	112400906	112400906	+	Missense_Mutation	SNP	C	C	A													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctgccgactttctgaatttCtctaaaatctggtcttggta							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:112400906C>A	uc003pvq.2	-	6	492	c.378G>T	c.(376-378)GAG>GAT	p.E126D	TUBE1_uc003pvr.2_Missense_Mutation_p.E51D	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	126					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TTCTGAATTTCTCTAAAATCT	0.358													1	0	1.01871e-10	0.008871	1.06056e-10	20	25										A	112400906	C	A	112400906	3	1	117	1	0	0	0	0	1	0	0	0	16760	912	32	3	1077	3	TUBE1	6	112400906	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	8	112400906	58714161	204	35194	181	2								
LAMA4	3910	broad.mit.edu	37	chr6	112452258	112452258	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aactttgattccctttacatCcatgatgacagtaccattat	4	10	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:112452258C>T	uc003pvu.2	-	29	4189	c.3880G>A	c.(3880-3882)GAT>AAT	p.D1294N	LAMA4_uc003pvv.2_Missense_Mutation_p.D1287N|LAMA4_uc003pvt.2_Missense_Mutation_p.D1287N	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1294	Laminin G-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CCCTTTACATCCATGATGACA	0.458													0	0	0	0.005443	0	23	42										T	112452258	C	T	112452258	3	4	117	1	0	0	0	0	1	0	0	0	8608	855	30	1	1635	1	LAMA4	6	112452258	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	51352	112452258	58662809	205	35195										
DSE	29940	broad.mit.edu	37	chr6	116757927	116757927	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agatactgtcccgagtccggAacacagctagctttaggaag	11	10	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:116757927A>C	uc003pws.2	+	6	2490	c.2296A>C	c.(2296-2298)AAC>CAC	p.N766H	DSE_uc011ebg.1_Missense_Mutation_p.N785H|DSE_uc003pwt.2_Missense_Mutation_p.N766H|DSE_uc003pwu.2_Missense_Mutation_p.N433H	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	766					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		CCGAGTCCGGAACACAGCTAG	0.478													0	0	0	0.00632	0	24	43										C	116757927	A	C	116757927	3	2	117	1	0	0	0	0	1	0	0	0	4774	246	9	5	2314	5	DSE	6	116757927	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	4305669	116757927	54357140	206	35196										
LAMA2	3908	broad.mit.edu	37	chr6	129634083	129634083	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caatgcaactgtcatccaaaAttctctggtgcaaaatgtac	6	10	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:129634083A>T	uc003qbn.2	+	23	3357	c.3252A>T	c.(3250-3252)AAA>AAT	p.K1084N	LAMA2_uc003qbo.2_Missense_Mutation_p.K1084N	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1084	Laminin EGF-like 12.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTCATCCAAAATTCTCTGGTG	0.473													0	0	0	0.010729	0	12	18										T	129634083	A	T	129634083	3	4	117	1	0	0	0	0	1	0	0	0	8606	98	4	5	3342	5	LAMA2	6	129634083	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	12876156	129634083	41480984	207	35197										
HBS1L	10767	broad.mit.edu	37	chr6	135318567	135318567	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agttgagtagctgcttccctCcttgccgcttctccagttcc	8	15	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:135318567C>T	uc003qez.2	-	6	974	c.767G>A	c.(766-768)GGA>GAA	p.G256E	HBS1L_uc003qey.2_Missense_Mutation_p.G92E|HBS1L_uc011ecy.1_Intron|HBS1L_uc011ecz.1_Missense_Mutation_p.G92E|HBS1L_uc011eda.1_Missense_Mutation_p.G214E	NM_006620	NP_006611	Q9Y450	HBS1L_HUMAN	Hsp70 subfamily B suppressor 1-like protein	256					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		CTGCTTCCCTCCTTGCCGCTT	0.542													0	0	0	0.004878	0	29	57										T	135318567	C	T	135318567	3	4	117	1	0	0	0	0	1	0	0	0	6987	855	30	1	1339	1	HBS1L	6	135318567	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5684484	135318567	35796500	208	35198										
MAP3K5	4217	broad.mit.edu	37	chr6	136882784	136882784	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tacaggcaattcaggaatttCtagaacagaattttgggaag	10	5	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:136882784C>T	uc003qhc.2	-	28	4236	c.3875_splice	c.e28-1	p.E1292_splice	MAP3K5_uc011edj.1_Splice_Site_p.E539_splice	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TCAGGAATTTCTAGAACAGAA	0.358													0	0	0	0.004482	0	9	15										T	136882784	C	T	136882784	5	4	117	1	0	0	0	0	0	0	1	0	9253	927	32	1	262	1	MAP3K5	6	136882784	Splice_Site	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1564217	136882784	34232283	209	35199										
LRP11	84918	broad.mit.edu	37	chr6	150174190	150174190	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agtgcccactcatactggacGatggcgtggtcatctgtgct	12	11	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:150174190G>A	uc003qng.2	-	2	1044	c.720C>T	c.(718-720)ATC>ATT	p.I240I	LRP11_uc003qnh.1_Silent_p.I240I	NM_032832	NP_116221	Q86VZ4	LRP11_HUMAN	low density lipoprotein receptor-related protein	240	PKD.|Extracellular (Potential).					integral to membrane	receptor activity				0		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;4.56e-12)|GBM - Glioblastoma multiforme(68;0.225)		CATACTGGACGATGGCGTGGT	0.562													0	0	0	0.00361	0	37	32										A	150174190	G	A	150174190	2	1	117	1	0	0	0	0	0	0	0	1	8953	1048	37	1		1	LRP11	6	150174190	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	13291406	150174190	20940877	210	35200										
SYNE1	23345	broad.mit.edu	37	chr6	152737832	152737832	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttctaatgctttagcattttGaagagcatcattgaggtcct	8	7	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:152737832G>A	uc010kiw.2	-	41	6342	c.5740C>T	c.(5740-5742)CAA>TAA	p.Q1914*	SYNE1_uc003qot.3_Nonsense_Mutation_p.Q1921*|SYNE1_uc003qou.3_Nonsense_Mutation_p.Q1914*|SYNE1_uc010kjb.1_Nonsense_Mutation_p.Q1897*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1914	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTAGCATTTTGAAGAGCATCA	0.458										HNSCC(10;0.0054)			0	0	0	0.006214	0	9	21										A	152737832	G	A	152737832	4	1	117	1	0	0	0	0	0	1	0	0	15442	1299	45	1	21150	1	SYNE1	6	152737832	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2563642	152737832	18377235	211	35201										
SYNE1	23345	broad.mit.edu	37	chr6	152765587	152765587	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgtgcttcaaacagattttCagtatccaagatcttctcag	6	10	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:152765587C>T	uc010kiw.2	-	30	4398	c.3796G>A	c.(3796-3798)GAA>AAA	p.E1266K	SYNE1_uc003qot.3_Missense_Mutation_p.E1273K|SYNE1_uc003qou.3_Missense_Mutation_p.E1266K|SYNE1_uc010kjb.1_Missense_Mutation_p.E1249K|SYNE1_uc003qow.2_Missense_Mutation_p.E561K|SYNE1_uc003qox.1_Missense_Mutation_p.E782K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1266	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AACAGATTTTCAGTATCCAAG	0.368										HNSCC(10;0.0054)			0	0	0	0.012213	0	25	38										T	152765587	C	T	152765587	3	4	117	1	0	0	0	0	1	0	0	0	15442	835	29	1	23138	1	SYNE1	6	152765587	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	27755	152765587	18349480	212	35202										
SYNE1	23345	broad.mit.edu	37	chr6	152768689	152768689	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttctcagaagaaacttctgtCaaaactttcagcctggattt	6	9	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr6:152768689C>G	uc010kiw.2	-	29	4175	c.3573G>C	c.(3571-3573)TTG>TTC	p.L1191F	SYNE1_uc003qot.3_Missense_Mutation_p.L1198F|SYNE1_uc003qou.3_Missense_Mutation_p.L1191F|SYNE1_uc010kjb.1_Missense_Mutation_p.L1174F|SYNE1_uc003qow.2_Missense_Mutation_p.L486F|SYNE1_uc003qox.1_Missense_Mutation_p.L707F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1191	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAACTTCTGTCAAAACTTTCA	0.458										HNSCC(10;0.0054)			0	0	0	0.009535	0	26	41										G	152768689	C	G	152768689	3	3	117	1	0	0	0	0	1	0	0	0	15442	825	29	1	23365	1	SYNE1	6	152768689	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3102	152768689	18346378	213	35203										
PAPOLB	56903	broad.mit.edu	37	chr7	4899851	4899851	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggcacagacatgctgttttCacagcctgcagacaagtcaa	9	11	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:4899851C>G	uc003snk.2	-	1	1775	c.1591G>C	c.(1591-1593)GAA>CAA	p.E531Q	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	530					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		ATGCTGTTTTCACAGCCTGCA	0.468													0	0	0	0.00361	0	54	44										G	4899851	C	G	4899851	3	3	117	1	0	0	0	0	1	0	0	0	11430	835	29	1	326	1	PAPOLB	7	4899851	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		4899851	154238812	214	35204										
DNAH11	8701	broad.mit.edu	37	chr7	21840770	21840770	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttcaggatctggatcgaaatCtgagcagactcacggcttca	10	10	5	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:21840770C>T	uc003svc.2	+	63	10094	c.10063C>T	c.(10063-10065)CTG>TTG	p.L3355L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3355	Potential.|Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGATCGAAATCTGAGCAGACT	0.373									Kartagener_syndrome				0	0	0	0.004672	0	3	10										T	21840770	C	T	21840770	2	4	117	1	0	0	0	0	0	0	0	1	4599	912	32	1		1	DNAH11	7	21840770	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	16940919	21840770	137297893	215	35205										
MPP6	51678	broad.mit.edu	37	chr7	24681456	24681456	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggatgaaaatgtggcagaatTggttggtatactcaaagaac	12	4	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:24681456T>G	uc003swx.2	+	4	538	c.239T>G	c.(238-240)TTG>TGG	p.L80W	MPP6_uc003swy.2_Missense_Mutation_p.L80W	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	80	L27 2.				protein complex assembly		protein binding				0						GTGGCAGAATTGGTTGGTATA	0.378													0	0	0	0.00245	0	11	113										G	24681456	T	G	24681456	3	3	117	1	0	0	0	0	1	0	0	0	9738	1821	63	5	245	5	MPP6	7	24681456	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	2840686	24681456	134457207	216	35206										
TAX1BP1	8887	broad.mit.edu	37	chr7	27825064	27825064	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacatgaaagagaacaacttGaatgtcagttgaagacagag	10	5	1	6			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:27825064G>C	uc003szl.2	+	7	966	c.808G>C	c.(808-810)GAA>CAA	p.E270Q	TAX1BP1_uc011jzo.1_Missense_Mutation_p.E270Q|TAX1BP1_uc003szk.2_Missense_Mutation_p.E270Q|TAX1BP1_uc011jzp.1_Missense_Mutation_p.E113Q	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	270	Potential.				anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			AGAACAACTTGAATGTCAGTT	0.214													0	0	0	0.00361	0	45	62										C	27825064	G	C	27825064	3	2	117	1	0	0	0	0	1	0	0	0	15591	1291	45	1	830	1	TAX1BP1	7	27825064	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3143608	27825064	131313599	217	35207										
NT5C3	51251	broad.mit.edu	37	chr7	33066465	33066465	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctcctttgataagaccacaGataatttcttctactcttgt	4	11	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:33066465G>A	uc003tdk.2	-	2	293	c.216C>T	c.(214-216)ATC>ATT	p.I72I	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Silent_p.I33I|NT5C3_uc003tdj.2_Silent_p.I33I	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	72					nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			TAAGACCACAGATAATTTCTT	0.264													0	0	0	0.003163	0	13	63										A	33066465	G	A	33066465	2	1	117	1	0	0	0	0	0	0	0	1	10688	932	33	1		1	NT5C3	7	33066465	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5241401	33066465	126072198	218	35208										
BBS9	27241	broad.mit.edu	37	chr7	33644572	33644572	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	accacagacatctcactgcaGagacacccaggcctggtaag	9	14	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:33644572G>A	uc003tdn.1	+	22	3130	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K	BBS9_uc003tdo.1_Missense_Mutation_p.E838K|BBS9_uc003tdp.1_Missense_Mutation_p.E868K|BBS9_uc003tdq.1_Missense_Mutation_p.E833K|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.E397K|BBS9_uc003tds.1_Missense_Mutation_p.E296K|BBS9_uc003tdt.2_Intron	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	873					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TCTCACTGCAGAGACACCCAG	0.453									Bardet-Biedl_syndrome				0	0	0	0.004007	0	15	18										A	33644572	G	A	33644572	3	1	117	1	0	0	0	0	1	0	0	0	1342	943	33	1	2699	1	BBS9	7	33644572	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	578107	33644572	125494091	219	35209										
POU6F2	11281	broad.mit.edu	37	chr7	39500145	39500145	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tttttaaaaacatctccacaGatcctcaaacggcagcgggt	7	11	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:39500145G>A	uc003thb.1	+	9	1445	c.1403_splice	c.e9-1	p.N468_splice		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CATCTCCACAGATCCTCAAAC	0.453													0	0	0	0.005443	0	21	27										A	39500145	G	A	39500145	5	1	117	1	0	0	0	0	0	0	1	0	12285	956	33	1	1436	1	POU6F2	7	39500145	Splice_Site	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5855573	39500145	119638518	220	35210										
BLVRA	644	broad.mit.edu	37	chr7	43830958	43830958	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgagagctccagccatgaggActacatcaggtgggttttcc	12	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:43830958A>G	uc003tir.2	+	4	328	c.245A>G	c.(244-246)GAC>GGC	p.D82G	BLVRA_uc010kxv.2_Missense_Mutation_p.D82G	NM_000712	NP_000703	P53004	BIEA_HUMAN	biliverdin reductase A precursor	82					heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)	AGCCATGAGGACTACATCAGG	0.323													0	0	0	0.00361	0	103	55										G	43830958	A	G	43830958	3	3	117	1	0	0	0	0	1	0	0	0	1451	275	10	5	255	5	BLVRA	7	43830958	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	4330813	43830958	115307705	221	35211										
H2AFV	94239	broad.mit.edu	37	chr7	44880509	44880509	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtacaaacctctgcagtgaGgtactccagaatcgcagcac	9	12	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:44880509G>A	uc003tma.2	-	3	339	c.184C>T	c.(184-186)CTC>TTC	p.L62F	H2AFV_uc003tlz.2_Missense_Mutation_p.L62F|H2AFV_uc003tmb.2_Intron|H2AFV_uc003tmc.2_Missense_Mutation_p.L62F|H2AFV_uc003tmd.2_Missense_Mutation_p.L36F	NM_012412	NP_036544	Q71UI9	H2AV_HUMAN	H2A histone family, member V isoform 1	62					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TCTGCAGTGAGGTACTCCAGA	0.502													0	0	0	0.00361	0	86	40										A	44880509	G	A	44880509	3	1	117	1	0	0	0	0	1	0	0	0	6927	1000	35	2	238	2	H2AFV	7	44880509	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1049551	44880509	114258154	222	35212										
TBRG4	9238	broad.mit.edu	37	chr7	45142089	45142089	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgaccccagcttctcatgtAcctgggcaaggatagagtgt	11	11	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:45142089A>C	uc003tmv.2	-	7	1304	c.1178T>G	c.(1177-1179)GTA>GGA	p.V393G	TBRG4_uc003tmu.2_Missense_Mutation_p.V218G|TBRG4_uc003tmw.2_Missense_Mutation_p.V283G|TBRG4_uc003tmx.2_Missense_Mutation_p.V283G|TBRG4_uc011kcd.1_Missense_Mutation_p.V404G	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	393					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CTTCTCATGTACCTGGGCAAG	0.597													0	0	0	0.003954	0	24	168										C	45142089	A	C	45142089	3	2	117	1	0	0	0	0	1	0	0	0	15646	405	14	5	737	5	TBRG4	7	45142089	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	261580	45142089	113996574	223	35213										
DDC	1644	broad.mit.edu	37	chr7	50537777	50537777	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaaaacaaagtcaccttgcgGatataagcctgcagtccttt	7	10	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:50537777G>C	uc003tpf.3	-	12	1220	c.1134C>G	c.(1132-1134)ATC>ATG	p.I378M	DDC_uc010kza.2_Missense_Mutation_p.I293M|DDC_uc003tpg.3_Missense_Mutation_p.I378M	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	378					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TCACCTTGCGGATATAAGCCT	0.338													0	0	0	0.009535	0	27	139										C	50537777	G	C	50537777	3	2	117	1	0	0	0	0	1	0	0	0	4325	1164	41	1	320	1	DDC	7	50537777	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5395688	50537777	108600886	224	35214										
GRB10	2887	broad.mit.edu	37	chr7	50737442	50737442	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttgcggcggcctggctcgGaggtaaagaacccggcgtga	16	11	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:50737442G>C	uc003tpi.2	-	4	512	c.481C>G	c.(481-483)CCG>GCG	p.P161A	GRB10_uc003tph.3_Missense_Mutation_p.P103A|GRB10_uc003tpj.2_Missense_Mutation_p.P161A|GRB10_uc003tpk.2_Missense_Mutation_p.P161A|GRB10_uc010kzb.2_Missense_Mutation_p.P103A|GRB10_uc003tpl.2_Missense_Mutation_p.P155A|GRB10_uc003tpm.2_Missense_Mutation_p.P103A|GRB10_uc003tpn.2_Missense_Mutation_p.P103A	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	161					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					GCCTGGCTCGGAGGTAAAGAA	0.592									Russell-Silver_syndrome				0	0	0	0.00623	0	34	31										C	50737442	G	C	50737442	3	2	117	1	0	0	0	0	1	0	0	0	6756	1174	41	1	1355	1	GRB10	7	50737442	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	199665	50737442	108401221	225	35215										
WBSCR28	135886	broad.mit.edu	37	chr7	73280067	73280068	+	Frame_Shift_Ins	INS	-	-	C													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgcaggctgcctttgagcaINScacgacccagctggccgagg							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:73280067_73280068insC	uc003tzk.2	+	3	698_699	c.662_663insC	c.(661-663)CACfs	p.H221fs	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_Frame_Shift_Ins_p.H120fs	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	221						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				GCCTTTGAGCACACGACCCAGC	0.629																		7	511	---	---								C	73280068	-	C	73280067	7	5	117	1	0	1	1	0	0	0	0	0	17264	159	6	0	672	0	WBSCR28	7	73280067	Frame_Shift_Ins	INS	-	TCGA-GV-A3JZ-01A-11D-A21A-08	22542625	73280067	85858596	226	35216										
ELN	2006	broad.mit.edu	37	chr7	73474260	73474260	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctcctggagttggcgtggctCctggtgtcggtgtggctcct	16	11	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:73474260C>T	uc003tzw.2	+	23	1568	c.1477C>T	c.(1477-1479)CCT>TCT	p.P493S	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Missense_Mutation_p.P487S|ELN_uc003tzz.2_Missense_Mutation_p.P406S|ELN_uc003tzo.2_Missense_Mutation_p.P454S|ELN_uc003tzp.2_Missense_Mutation_p.P398S|ELN_uc003tzq.2_Missense_Mutation_p.P351S|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Missense_Mutation_p.P468S|ELN_uc003tzt.2_Missense_Mutation_p.P492S|ELN_uc003tzu.2_Missense_Mutation_p.P473S|ELN_uc003tzv.2_Missense_Mutation_p.P458S|ELN_uc003tzx.2_Missense_Mutation_p.P477S|ELN_uc011kff.1_Missense_Mutation_p.P487S|ELN_uc003tzy.2_Missense_Mutation_p.P463S	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	516	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGGCGTGGCTCCTGGTGTCGG	0.547			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						0	0	0	0.00361	0	130	179										T	73474260	C	T	73474260	3	4	117	1	0	0	0	0	1	0	0	0	5071	855	30	1	1564	1	ELN	7	73474260	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	194193	73474260	85664403	227	35217										
FGL2	10875	broad.mit.edu	37	chr7	76828885	76828885	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gacttctttgaacacctcctCgatcctgctgaattgcttcg	7	13	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:76828885C>G	uc003ugb.2	-	1	266	c.226G>C	c.(226-228)GAG>CAG	p.E76Q	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.2_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	fibrinogen-like 2 precursor	76	Potential.				signal transduction	fibrinogen complex	receptor binding			skin(2)	2						AACACCTCCTCGATCCTGCTG	0.507													0	0	0	0.009535	0	27	85										G	76828885	C	G	76828885	3	3	117	1	0	0	0	0	1	0	0	0	5873	893	31	1	1101	1	FGL2	7	76828885	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3354625	76828885	82309778	228	35218										
SEMA3E	9723	broad.mit.edu	37	chr7	82997265	82997265	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acaaagctatgctctactgtCtggcaaaaataggtcccagc	8	11	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:82997265C>T	uc003uhy.1	-	17	2431	c.1965G>A	c.(1963-1965)CAG>CAA	p.Q655Q		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	655	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GCTCTACTGTCTGGCAAAAAT	0.443													0	0	0	0.009718	0	38	62										T	82997265	C	T	82997265	2	4	117	1	0	0	0	0	0	0	0	1	14028	912	32	1		1	SEMA3E	7	82997265	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6168380	82997265	76141398	229	35219										
ADAM22	53616	broad.mit.edu	37	chr7	87757967	87757967	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaaaccaaatacattgaactGatgattgtgaatgatcacct	7	7	1	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:87757967G>C	uc003ujn.2	+	9	808	c.729G>C	c.(727-729)CTG>CTC	p.L243L	ADAM22_uc003uji.1_Silent_p.L242L|ADAM22_uc003ujj.1_Silent_p.L243L|ADAM22_uc003ujk.1_Silent_p.L243L|ADAM22_uc003ujl.1_Silent_p.L243L|ADAM22_uc003ujm.2_Silent_p.L243L|ADAM22_uc003ujo.2_Silent_p.L243L|ADAM22_uc003ujp.1_Silent_p.L295L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	243	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ACATTGAACTGATGATTGTGA	0.383													0	0	0	0.007835	0	31	51										C	87757967	G	C	87757967	2	2	117	1	0	0	0	0	0	0	0	1	244	1277	45	1		1	ADAM22	7	87757967	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4760702	87757967	71380696	230	35220										
C7orf64	84060	broad.mit.edu	37	chr7	92158136	92158136	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaagtaggcaagatggcgtcGagcggcggggagctagggag	20	6	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:92158136G>A	uc003ulz.2	+	1	50	c.9G>A	c.(7-9)TCG>TCA	p.S3S	PEX1_uc003uly.2_5'Flank|PEX1_uc011khr.1_5'Flank|PEX1_uc010ley.2_5'Flank|PEX1_uc011khs.1_5'Flank|C7orf64_uc011khu.1_Silent_p.S3S|C7orf64_uc003uma.2_Silent_p.S3S	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	3							nucleotide binding			ovary(2)	2						AGATGGCGTCGAGCGGCGGGG	0.567													0	0	0	0.003271	0	28	35										A	92158136	G	A	92158136	2	1	117	1	0	0	0	0	0	0	0	1	2410	1045	37	1		1	C7orf64	7	92158136	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4400169	92158136	66980527	231	35221										
TRRAP	8295	broad.mit.edu	37	chr7	98522777	98522777	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcctgaaaagcgccaacactGagccctactaccggaggcag	11	14	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:98522777G>A	uc003upp.2	+	22	3075	c.2866G>A	c.(2866-2868)GAG>AAG	p.E956K	TRRAP_uc011kis.1_Missense_Mutation_p.E956K|TRRAP_uc003upr.2_Missense_Mutation_p.E648K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	956					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGCCAACACTGAGCCCTACTA	0.507													0	0	0	0.00361	0	44	68										A	98522777	G	A	98522777	3	1	117	1	0	0	0	0	1	0	0	0	16598	1291	45	1	2948	1	TRRAP	7	98522777	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6364641	98522777	60615886	232	35222										
TRRAP	8295	broad.mit.edu	37	chr7	98534849	98534849	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctgcactcttcaaagccctGaattccaccaatagtgagct	7	13	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:98534849G>A	uc003upp.2	+	29	4391	c.4182G>A	c.(4180-4182)CTG>CTA	p.L1394L	TRRAP_uc011kis.1_Silent_p.L1394L|TRRAP_uc003upr.2_Silent_p.L1086L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1394					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCAAAGCCCTGAATTCCACCA	0.363													0	0	0	0.00361	0	49	203										A	98534849	G	A	98534849	2	1	117	1	0	0	0	0	0	0	0	1	16598	1277	45	1		1	TRRAP	7	98534849	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12072	98534849	60603814	233	35223										
PILRA	29992	broad.mit.edu	37	chr7	99995535	99995535	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	taaagccacaaccccagccaGgtgagtgctgggcctcccca	10	16	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:99995535G>T	uc003uuo.1	+	4	919	c.707G>T	c.(706-708)AGG>ATG	p.R236M	PILRA_uc011kjo.1_Missense_Mutation_p.R163M|PILRA_uc003uup.1_Missense_Mutation_p.R163M|PILRA_uc003uuq.1_Intron	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	236	Cytoplasmic (Potential).				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACCCCAGCCAGGTGAGTGCTG	0.612													1	0	4.65686e-17	0.003755	4.98194e-17	32	126										T	99995535	G	T	99995535	3	4	117	1	0	0	0	0	1	0	0	0	11925	1014	35	4	721	4	PILRA	7	99995535	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1460686	99995535	59143128	234	35224										
TFR2	7036	broad.mit.edu	37	chr7	100231073	100231073	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cagccccacgtagtgcgtgtCggtccacacgtggtccagct	12	15	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:100231073C>T	uc003uvv.1	-	4	621	c.580G>A	c.(580-582)GAC>AAC	p.D194N	TFR2_uc010lhc.1_5'Flank|TFR2_uc003uvu.1_Missense_Mutation_p.D23N	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	194	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TAGTGCGTGTCGGTCCACACG	0.512													0	0	0	0.00333	0	20	29										T	100231073	C	T	100231073	3	4	117	1	0	0	0	0	1	0	0	0	15808	884	31	1	1885	1	TFR2	7	100231073	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	235538	100231073	58907590	235	35225										
ZAN	7455	broad.mit.edu	37	chr7	100363105	100363105	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtgaatgcaatccgggcttCgtcctcagtggcctcgagtg	13	11	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:100363105C>T	uc003uwj.2	+	23	4563	c.4398C>T	c.(4396-4398)TTC>TTT	p.F1466F	ZAN_uc003uwk.2_Silent_p.F1466F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.F43F	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1466	TIL 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ATCCGGGCTTCGTCCTCAGTG	0.627													0	0	0	0.004007	0	16	25										T	100363105	C	T	100363105	2	4	117	1	0	0	0	0	0	0	0	1	17510	883	31	1		1	ZAN	7	100363105	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	132032	100363105	58775558	236	35226										
FEZF1	389549	broad.mit.edu	37	chr7	121942239	121942239	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcggacatgcttcttgaggtCaaagttcctgcagaaaccct	10	11	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:121942239C>T	uc003vkd.2	-	4	1314	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	FEZF1_uc003vkc.2_Missense_Mutation_p.D364N|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	414	C2H2-type 6.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						TTCTTGAGGTCAAAGTTCCTG	0.527													0	0	0	0.010771	0	42	141										T	121942239	C	T	121942239	3	4	117	1	0	0	0	0	1	0	0	0	5825	826	29	1	191	1	FEZF1	7	121942239	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	21579134	121942239	37196424	237	35227										
IQUB	154865	broad.mit.edu	37	chr7	123092843	123092843	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	taatcttaggtgttgtgtctGagtgatacttccatctgatc	9	7	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:123092843G>C	uc003vkn.2	-	13	2907	c.2330C>G	c.(2329-2331)TCA>TGA	p.S777*	IQUB_uc011kny.1_Nonsense_Mutation_p.S110*|IQUB_uc003vko.2_Nonsense_Mutation_p.S777*|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	777										ovary(3)|large_intestine(1)	4						TGTTGTGTCTGAGTGATACTT	0.398													0	0	0	0.008871	0	18	19										C	123092843	G	C	123092843	4	2	117	1	0	0	0	0	0	1	0	0	7820	1294	45	1	49	1	IQUB	7	123092843	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1150604	123092843	36045820	238	35228										
RBM28	55131	broad.mit.edu	37	chr7	127978389	127978389	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acaaaaccaaaaccgcgcatCttcccatctgtgtgcaaatg	6	13	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:127978389C>T	uc003vmp.2	-	5	571	c.456G>A	c.(454-456)AAG>AAA	p.K152K	RBM28_uc003vmo.2_5'Flank|RBM28_uc011koj.1_Intron|RBM28_uc011kok.1_Silent_p.K99K	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	152	RRM 2.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						AACCGCGCATCTTCCCATCTG	0.418													0	0	0	0.00499	0	14	51										T	127978389	C	T	127978389	2	4	117	1	0	0	0	0	0	0	0	1	13128	912	32	1		1	RBM28	7	127978389	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4885546	127978389	31160274	239	35229										
KIAA1147	57189	broad.mit.edu	37	chr7	141364706	141364706	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccttagctgccactacctCtgctcgttgagccggcggta	10	16	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:141364706C>A	uc003vwk.2	-	7	1101	c.1101G>T	c.(1099-1101)CAG>CAT	p.Q367H		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	367										ovary(1)	1	Melanoma(164;0.0171)					GCCACTACCTCTGCTCGTTGA	0.597													1	0	9.16793e-09	0.00499	9.48456e-09	11	19										A	141364706	C	A	141364706	3	1	117	1	0	0	0	0	1	0	0	0	8210	912	32	3	278	3	KIAA1147	7	141364706	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	13386317	141364706	17773957	240	35230										
NOBOX	135935	broad.mit.edu	37	chr7	144097329	144097329	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggggggtcacccccaccgtCtgggcaatctctcggcgttt	13	14	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:144097329C>T	uc011kue.1	-	5	921	c.921G>A	c.(919-921)CAG>CAA	p.Q307Q		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	307	Homeobox.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					CCCCCACCGTCTGGGCAATCT	0.552													0	0	0	0.002836	0	30	60										T	144097329	C	T	144097329	2	4	117	1	0	0	0	0	0	0	0	1	10512	912	32	1		1	NOBOX	7	144097329	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2732623	144097329	15041334	241	35231										
NOS3	4846	broad.mit.edu	37	chr7	150696118	150696118	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggccccagatgatcccccaGaactcttccttctgcccccc	6	20	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:150696118G>A	uc003wif.2	+	8	1197	c.901G>A	c.(901-903)GAA>AAA	p.E301K	NOS3_uc011kuy.1_Missense_Mutation_p.E95K|NOS3_uc011kuz.1_Missense_Mutation_p.E301K|NOS3_uc011kva.1_Missense_Mutation_p.E301K|NOS3_uc011kvb.1_Missense_Mutation_p.E301K	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	301	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TGATCCCCCAGAACTCTTCCT	0.657													0	0	0	0.00361	0	44	227										A	150696118	G	A	150696118	3	1	117	1	0	0	0	0	1	0	0	0	10544	943	33	1	927	1	NOS3	7	150696118	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6598789	150696118	8442545	242	35232										
ATG9B	285973	broad.mit.edu	37	chr7	150714325	150714325	+	Missense_Mutation	SNP	G	G	C													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgccgtcctccgcacgctgaGacagcgaggcctcagtctgt							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:150714325G>C	uc011kvc.1	-	9	2163	c.2087C>G	c.(2086-2088)TCT>TGT	p.S696C	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	696	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGCACGCTGAGACAGCGAGGC	0.592													0	0	0	0.00632	0	23	31										C	150714325	G	C	150714325	3	2	117	1	0	0	0	0	1	0	0	0	1103	942	33	1	706	1	ATG9B	7	150714325	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	18207	150714325	8424338	243	35233	182	2								
ATG9B	285973	broad.mit.edu	37	chr7	150714331	150714331	+	Missense_Mutation	SNP	G	G	A													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctccgcacgctgagacagcGaggcctcagtctgtcccgcc							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:150714331G>A	uc011kvc.1	-	9	2157	c.2081C>T	c.(2080-2082)TCG>TTG	p.S694L	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	694	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGAGACAGCGAGGCCTCAGT	0.582													0	0	0	0.00632	0	24	35										A	150714331	G	A	150714331	3	1	117	1	0	0	0	0	1	0	0	0	1103	1059	37	1	712	1	ATG9B	7	150714331	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6	150714331	8424332	244	35234	182	2								
WDR60	55112	broad.mit.edu	37	chr7	158672547	158672547	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agagaaaagtaattcattctCtgacaaaggggaagaaagac	10	5	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr7:158672547C>T	uc003woe.3	+	5	904	c.746C>T	c.(745-747)TCT>TTT	p.S249F	WDR60_uc010lqv.2_RNA	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	249										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		AATTCATTCTCTGACAAAGGG	0.398													0	0	0	0.001368	0	12	11										T	158672547	C	T	158672547	3	4	117	1	0	0	0	0	1	0	0	0	17308	913	32	1	764	1	WDR60	7	158672547	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7958216	158672547	466116	245	35235										
NEFM	4741	broad.mit.edu	37	chr8	24771416	24771416	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccgtccagtggcttccgctCgcagtcgtggtcccgcggct	13	17	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:24771416C>T	uc003xed.3	+	1	143	c.110C>T	c.(109-111)TCG>TTG	p.S37L	NEFM_uc011lac.1_Missense_Mutation_p.S37L|NEFM_uc010lue.2_5'Flank|uc010luc.1_3'UTR	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	37	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GGCTTCCGCTCGCAGTCGTGG	0.697													0	0	0	0.012319	0	17	13										T	24771416	C	T	24771416	3	4	117	1	0	0	0	0	1	0	0	0	10316	893	31	1	112	1	NEFM	8	24771416	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		24771416	121592606	246	35236										
CHRNA6	8973	broad.mit.edu	37	chr8	42611280	42611280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttgtccagaggccacctcatCagcaggacctggggcagcag	13	13	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:42611280C>T	uc003xpj.2	-	5	1108	c.1062G>A	c.(1060-1062)CTG>CTA	p.L354L	CHRNA6_uc011lcw.1_Silent_p.L339L	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	354	Cytoplasmic.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			GCCACCTCATCAGCAGGACCT	0.587													0	0	0	0.00361	0	53	38										T	42611280	C	T	42611280	2	4	117	1	0	0	0	0	0	0	0	1	3387	813	29	1		1	CHRNA6	8	42611280	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	17839864	42611280	103752742	247	35237										
ST18	9705	broad.mit.edu	37	chr8	53062480	53062480	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcagacttgtccaggattcGattttttttcatgcttaagt	8	7	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:53062480G>C	uc003xqz.2	-	11	2020	c.1864C>G	c.(1864-1866)CGA>GGA	p.R622G	ST18_uc011ldq.1_Missense_Mutation_p.R269G|ST18_uc011ldr.1_Missense_Mutation_p.R587G|ST18_uc011lds.1_Missense_Mutation_p.R527G|ST18_uc003xra.2_Missense_Mutation_p.R622G|ST18_uc003xrb.2_Missense_Mutation_p.R622G	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	622						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCCAGGATTCGATTTTTTTTC	0.413													0	0	0	0.00499	0	16	77										C	53062480	G	C	53062480	3	2	117	1	0	0	0	0	1	0	0	0	15211	1066	37	1	1323	1	ST18	8	53062480	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	10451200	53062480	93301542	248	35238										
ST18	9705	broad.mit.edu	37	chr8	53084386	53084386	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atttgtcttccacccatgtcGataactttggtttgcctcct	6	12	1	0	rs144551525		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:53084386G>A	uc003xqz.2	-	5	1191	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.I310I|ST18_uc011lds.1_Silent_p.I250I|ST18_uc003xra.2_Silent_p.I345I|ST18_uc003xrb.2_Silent_p.I345I	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	345						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CACCCATGTCGATAACTTTGG	0.403													0	0	0	0.00361	0	37	159										A	53084386	G	A	53084386	2	1	117	1	0	0	0	0	0	0	0	1	15211	1048	37	1		1	ST18	8	53084386	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	21906	53084386	93279636	249	35239										
RP1	6101	broad.mit.edu	37	chr8	55537511	55537511	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caactactgtcagtaaaactGgtccttctaataatgatgaa	6	8	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:55537511G>A	uc003xsd.1	+	4	1217	c.1069G>A	c.(1069-1071)GGT>AGT	p.G357S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	357					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CAGTAAAACTGGTCCTTCTAA	0.363													0	0	0	0.00308	0	7	18										A	55537511	G	A	55537511	3	1	117	1	0	0	0	0	1	0	0	0	13532	1348	47	2	1079	2	RP1	8	55537511	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2453125	55537511	90826511	250	35240										
RP1	6101	broad.mit.edu	37	chr8	55540055	55540055	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agaaagaacaagacatggttCcaatagatctttctgcaaat	7	7	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:55540055C>T	uc003xsd.1	+	4	3761	c.3613C>T	c.(3613-3615)CCA>TCA	p.P1205S	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1205					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AGACATGGTTCCAATAGATCT	0.423													0	0	0	0.002299	0	20	77										T	55540055	C	T	55540055	3	4	117	1	0	0	0	0	1	0	0	0	13532	855	30	1	3623	1	RP1	8	55540055	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2544	55540055	90823967	251	35241										
NCOA2	10499	broad.mit.edu	37	chr8	71036267	71036267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcatgttgttactgtacatgCtggtgtttgcttgctgccca	10	9	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:71036267C>T	uc003xyn.1	-	21	4307	c.4145G>A	c.(4144-4146)AGC>AAC	p.S1382N	NCOA2_uc011lfb.1_Missense_Mutation_p.S470N	NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	1382					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			ACTGTACATGCTGGTGTTTGC	0.473			T	RUNXBP2	AML								0	0	0	0.00361	0	40	23										T	71036267	C	T	71036267	3	4	117	1	0	0	0	0	1	0	0	0	10229	797	28	2	261	2	NCOA2	8	71036267	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	15496212	71036267	75327755	252	35242										
FAM92A1	137392	broad.mit.edu	37	chr8	94740514	94740514	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgttacagaagaagaaaatTttcttaagtaaactacacat	5	5	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:94740514T>C	uc010maq.2	+	8	962	c.859T>C	c.(859-861)TTT>CTT	p.F287L	FAM92A1_uc003yfv.3_RNA|FAM92A1_uc003yfx.3_RNA|FAM92A1_uc003yfw.3_RNA|FAM92A1_uc010mar.2_Missense_Mutation_p.F94L	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	287											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			AGAAGAAAATTTTCTTAAGTA	0.328													0	0	0	0.010818	0	28	9										C	94740514	T	C	94740514	3	2	117	1	0	0	0	0	1	0	0	0	5652	1841	64	5	889	5	FAM92A1	8	94740514	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	23704247	94740514	51623508	253	35243										
ODF1	4956	broad.mit.edu	37	chr8	103572771	103572771	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tatgcggttttgaacccgatCaagtcaaagttcgagtgaag	11	7	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:103572771C>G	uc003ykt.2	+	2	520	c.412C>G	c.(412-414)CAA>GAA	p.Q138E		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	138					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			TGAACCCGATCAAGTCAAAGT	0.448													0	0	0	0.00361	0	130	55										G	103572771	C	G	103572771	3	3	117	1	0	0	0	0	1	0	0	0	10826	827	29	1	418	1	ODF1	8	103572771	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	8832257	103572771	42791251	254	35244										
ODF1	4956	broad.mit.edu	37	chr8	103572958	103572958	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cagctgtgtcaagatcgagtCtccttgctacccttgcactt	8	13	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:103572958C>G	uc003ykt.2	+	2	707	c.599C>G	c.(598-600)TCT>TGT	p.S200C		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	200					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AAGATCGAGTCTCCTTGCTAC	0.343													0	0	0	0.00361	0	29	19										G	103572958	C	G	103572958	3	3	117	1	0	0	0	0	1	0	0	0	10826	913	32	1	605	1	ODF1	8	103572958	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	187	103572958	42791064	255	35245										
ATP6V1C1	528	broad.mit.edu	37	chr8	104064968	104064968	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttttcaaagggagtaactCagattgataatgacctgaaa	8	6	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:104064968C>G	uc003ykz.3	+	6	636	c.391C>G	c.(391-393)CAG>GAG	p.Q131E	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.Q56E|ATP6V1C1_uc003yla.2_Missense_Mutation_p.Q131E|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.Q56E	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	131					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			GGGAGTAACTCAGATTGATAA	0.318													0	0	0	0.008291	0	9	74										G	104064968	C	G	104064968	3	3	117	1	0	0	0	0	1	0	0	0	1180	827	29	1	409	1	ATP6V1C1	8	104064968	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	492010	104064968	42299054	256	35246										
GSDMC	56169	broad.mit.edu	37	chr8	130789625	130789625	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgacaatacctaggactgaaGaacttggctccaggatgtca	10	9	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:130789625G>C	uc003ysr.2	-	2	1091	c.209C>G	c.(208-210)TCT>TGT	p.S70C		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	70						mitochondrion				ovary(2)|skin(1)	3						TAGGACTGAAGAACTTGGCTC	0.443													0	0	0	0.010771	0	34	73										C	130789625	G	C	130789625	3	2	117	1	0	0	0	0	1	0	0	0	6818	942	33	1	1369	1	GSDMC	8	130789625	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	26724657	130789625	15574397	257	35247										
OC90	729330	broad.mit.edu	37	chr8	133044290	133044290	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccaggtgcaggaaggtgaatCtgtcacaggctgaaaggaac	14	8	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:133044290C>A	uc003ytg.2	-	11	869	c.869G>T	c.(868-870)AGA>ATA	p.R290I	OC90_uc011lix.1_Missense_Mutation_p.R290I	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	306					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			GAAGGTGAATCTGTCACAGGC	0.547													1	0	1.47857e-17	0.00361	1.58694e-17	41	275										A	133044290	C	A	133044290	3	1	117	1	0	0	0	0	1	0	0	0	10814	913	32	3	576	3	OC90	8	133044290	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2254665	133044290	13319732	258	35248										
TMEM71	137835	broad.mit.edu	37	chr8	133771110	133771110	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tactggtgttgacatcagttGagatattcggtacatcttgg	11	6	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:133771110G>C	uc003ytp.2	-	2	245	c.16C>G	c.(16-18)CAA>GAA	p.Q6E	TMEM71_uc003ytn.2_Missense_Mutation_p.Q6E|TMEM71_uc003yto.2_Missense_Mutation_p.Q6E	NM_144649	NP_653250	Q6P5X7	TMM71_HUMAN	transmembrane protein 71 isoform 1	6						integral to membrane				ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GACATCAGTTGAGATATTCGG	0.348													0	0	0	0.00361	0	50	254										C	133771110	G	C	133771110	3	2	117	1	0	0	0	0	1	0	0	0	16197	1299	45	1	907	1	TMEM71	8	133771110	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	726820	133771110	12592912	259	35249										
SLC45A4	57210	broad.mit.edu	37	chr8	142228490	142228492	+	In_Frame_Del	DEL	GCC	GCC	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcctgcctgcggaacgcgtGccgccgccgccgcatggagc							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:142228490_142228492delGCC	uc003ywd.1	-	4	1402_1404	c.1094_1096delGGC	c.(1093-1098)CGGCAC>CAC	p.R365del	SLC45A4_uc003ywc.1_In_Frame_Del_p.R365del|SLC45A4_uc010meq.1_In_Frame_Del_p.R363del	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	416					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGGAACGCGTGCCGCCGCCGCCG	0.675																		7	265	---	---								-	142228492	GCC	-	142228490	7	5	117	1	0	1	0	1	0	0	0	0	14643	1319	46	0	1320	0	SLC45A4	8	142228490	In_Frame_Del	DEL	GCC	TCGA-GV-A3JZ-01A-11D-A21A-08	8457380	142228490	4135532	260	35250										
EPPK1	83481	broad.mit.edu	37	chr8	144940345	144940345	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccgcgccggtaggccacgtcCacgggcacgcggtggctgtg	17	15	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:144940345C>T	uc003zaa.1	-	2	15100	c.15087G>A	c.(15085-15087)GTG>GTA	p.V5029V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5029	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGCCACGTCCACGGGCACGC	0.692													0	0	0	0.009718	0	34	663										T	144940345	C	T	144940345	2	4	117	1	0	0	0	0	0	0	0	1	5190	581	21	2		2	EPPK1	8	144940345	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2711855	144940345	1423677	261	35251										
EPPK1	83481	broad.mit.edu	37	chr8	144943935	144943935	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctcccctcctgcacgtcctCcagcaggcccctccgttgct	7	22	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:144943935C>G	uc003zaa.1	-	1	3500	c.3487G>C	c.(3487-3489)GAG>CAG	p.E1163Q		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1163						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCACGTCCTCCAGCAGGCCC	0.672													0	0	0	0.001168	0	5	23										G	144943935	C	G	144943935	3	3	117	1	0	0	0	0	1	0	0	0	5190	864	30	1	3779	1	EPPK1	8	144943935	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3590	144943935	1420087	262	35252										
HSF1	3297	broad.mit.edu	37	chr8	145535411	145535411	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctccccagcctacagcagctCcagcctctacgcccctgatg	7	20	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr8:145535411C>G	uc003zbt.3	+	8	919	c.749C>G	c.(748-750)TCC>TGC	p.S250C	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	250	Regulatory domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			TACAGCAGCTCCAGCCTCTAC	0.692													0	0	0	0.00361	0	41	163										G	145535411	C	G	145535411	3	3	117	1	0	0	0	0	1	0	0	0	7395	855	30	1	779	1	HSF1	8	145535411	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	591476	145535411	828611	263	35253										
KIAA1432	57589	broad.mit.edu	37	chr9	5772683	5772683	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtttaactcagtcagagctgGagcacatttccatggagttg	11	8	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:5772683G>A	uc003zji.2	+	23	3592	c.3499G>A	c.(3499-3501)GAG>AAG	p.E1167K	KIAA1432_uc003zjl.3_Missense_Mutation_p.E1130K|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1246						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		GTCAGAGCTGGAGCACATTTC	0.468													0	0	0	0.008871	0	19	128										A	5772683	G	A	5772683	3	1	117	1	0	0	0	0	1	0	0	0	8233	1175	41	1	3663	1	KIAA1432	9	5772683	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		5772683	135440748	264	35254										
RANBP6	26953	broad.mit.edu	37	chr9	6015556	6015556	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttcagaagctggtaaaactCttgcttttctgacacggtcg	9	10	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:6015556C>G	uc003zjr.2	-	1	63	c.52G>C	c.(52-54)GAG>CAG	p.E18Q	RANBP6_uc011lmf.1_Missense_Mutation_p.E18Q|RANBP6_uc003zjs.2_5'UTR	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	18					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TGGTAAAACTCTTGCTTTTCT	0.552													0	0	0	0.003755	0	30	304										G	6015556	C	G	6015556	3	3	117	1	0	0	0	0	1	0	0	0	13031	922	32	1	3269	1	RANBP6	9	6015556	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	242873	6015556	135197875	265	35255										
KIAA1797	54914	broad.mit.edu	37	chr9	20946772	20946772	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttattgaggctacagaggctGaggatgttatgaacaagctt	12	5	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:20946772G>A	uc003zog.1	+	32	3991	c.3628G>A	c.(3628-3630)GAG>AAG	p.E1210K	KIAA1797_uc003zoh.1_Missense_Mutation_p.E646K	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1210						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		TACAGAGGCTGAGGATGTTAT	0.448													0	0	0	0.00361	0	97	3										A	20946772	G	A	20946772	3	1	117	1	0	0	0	0	1	0	0	0	8258	1291	45	1	3742	1	KIAA1797	9	20946772	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	14931216	20946772	120266659	266	35256										
IFNA4	3441	broad.mit.edu	37	chr9	21186998	21186998	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atcttttttgcaagtttgttGaaaacgagagggatctcatg	10	5	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:21186998G>A	uc003zon.2	-	1	601	c.533C>T	c.(532-534)TCA>TTA	p.S178L		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	178					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CAAGTTTGTTGAAAACGAGAG	0.378													0	0	0	0.00361	0	324	34										A	21186998	G	A	21186998	3	1	117	1	0	0	0	0	1	0	0	0	7539	1294	45	1	40	1	IFNA4	9	21186998	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	240226	21186998	120026433	267	35257										
TEK	7010	broad.mit.edu	37	chr9	27203074	27203074	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacaacatagggtcaagcaaCccagccttttctcatgaact	6	12	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:27203074C>G	uc003zqi.3	+	13	2608	c.2166C>G	c.(2164-2166)AAC>AAG	p.N722K	TEK_uc011lno.1_Missense_Mutation_p.N679K|TEK_uc011lnp.1_Missense_Mutation_p.N575K|TEK_uc003zqj.1_Missense_Mutation_p.N656K	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	722	Extracellular (Potential).|Fibronectin type-III 3.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GGTCAAGCAACCCAGCCTTTT	0.473													0	0	0	0.001855	0	10	79										G	27203074	C	G	27203074	3	3	117	1	0	0	0	0	1	0	0	0	15748	506	18	4	2216	4	TEK	9	27203074	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6016076	27203074	114010357	268	35258										
NOL6	65083	broad.mit.edu	37	chr9	33466615	33466615	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccctgaacagcagacacggtCagtgggagaccctctagccc	11	15	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:33466615C>T	uc003zsz.2	-	16	2144	c.2043G>A	c.(2041-2043)CTG>CTA	p.L681L	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Silent_p.L678L|NOL6_uc011lob.1_Silent_p.L629L|NOL6_uc003ztb.1_Silent_p.L681L	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	681					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding	p.L681L(1)		ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CAGACACGGTCAGTGGGAGAC	0.622											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	94	71										T	33466615	C	T	33466615	2	4	117	1	0	0	0	0	0	0	0	1	10525	813	29	1		1	NOL6	9	33466615	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6263541	33466615	107746816	269	35259										
GNE	10020	broad.mit.edu	37	chr9	36246323	36246323	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacctgtctccatgaacaatCatgatatcaggcttcaggcg	8	11	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:36246323C>G	uc010mlh.2	-	3	536	c.321G>C	c.(319-321)ATG>ATC	p.M107I	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.M107I|GNE_uc011lpl.1_Missense_Mutation_p.M48I|GNE_uc010mli.2_Missense_Mutation_p.M138I|GNE_uc010mlj.2_Missense_Mutation_p.M102I	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	107	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CATGAACAATCATGATATCAG	0.522													0	0	0	0.007413	0	18	108										G	36246323	C	G	36246323	3	3	117	1	0	0	0	0	1	0	0	0	6522	826	29	1	1887	1	GNE	9	36246323	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2779708	36246323	104967108	270	35260										
GNE	10020	broad.mit.edu	37	chr9	36246416	36246416	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctgcctcatcttctcccctCacaattgtgtgtagcctggt	8	14	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:36246416C>G	uc010mlh.2	-	3	443	c.228G>C	c.(226-228)GTG>GTC	p.V76V	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Silent_p.V76V|GNE_uc011lpl.1_Silent_p.V17V|GNE_uc010mli.2_Silent_p.V107V|GNE_uc010mlj.2_Silent_p.V71V	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	76	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CTTCTCCCCTCACAATTGTGT	0.438													0	0	0	0.007291	0	24	173										G	36246416	C	G	36246416	2	3	117	1	0	0	0	0	0	0	0	1	6522	813	29	1		1	GNE	9	36246416	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	93	36246416	104967015	271	35261										
GNE	10020	broad.mit.edu	37	chr9	36249349	36249349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcggttatttccattcttctCcatgatttgcttgtttcgtt	6	9	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:36249349C>T	uc010mlh.2	-	2	219	c.4G>A	c.(4-6)GAG>AAG	p.E2K	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.E2K|GNE_uc011lpl.1_Intron|GNE_uc010mli.2_Missense_Mutation_p.E33K|GNE_uc010mlj.2_Intron	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	2	UDP-N-acetylglucosamine 2-epimerase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			CCATTCTTCTCCATGATTTGC	0.353													0	0	0	0.007413	0	17	134										T	36249349	C	T	36249349	3	4	117	1	0	0	0	0	1	0	0	0	6522	864	30	1	2208	1	GNE	9	36249349	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2933	36249349	104964082	272	35262										
DAPK1	1612	broad.mit.edu	37	chr9	90283556	90283556	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctagatcggaacagcacgaGcacgtagcaggtctccttgc	12	12	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:90283556G>C	uc004apc.2	+	19	2106	c.1968G>C	c.(1966-1968)GAG>GAC	p.E656D	DAPK1_uc004apd.2_Missense_Mutation_p.E656D|DAPK1_uc011ltg.1_Missense_Mutation_p.E656D|DAPK1_uc011lth.1_Missense_Mutation_p.E393D|DAPK1_uc004apf.1_Missense_Mutation_p.E210D	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	656					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						AACAGCACGAGCACGTAGCAG	0.428									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.00361	0	58	209										C	90283556	G	C	90283556	3	2	117	1	0	0	0	0	1	0	0	0	4235	962	34	4	2038	4	DAPK1	9	90283556	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	54034207	90283556	50929875	273	35263										
SPTLC1	10558	broad.mit.edu	37	chr9	94843181	94843181	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agggttatccaacaatccaaGaaaattaaatgaggcgaagt	9	6	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:94843181G>A	uc004arl.1	-	4	363	c.325C>T	c.(325-327)CTT>TTT	p.L109F	SPTLC1_uc011ltv.1_Missense_Mutation_p.L109F|SPTLC1_uc004arm.1_Missense_Mutation_p.L109F|SPTLC1_uc004arn.1_Missense_Mutation_p.L109F	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	109	Cytoplasmic (Potential).					integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	AACAATCCAAGAAAATTAAAT	0.373													0	0	0	0.008871	0	18	48										A	94843181	G	A	94843181	3	1	117	1	0	0	0	0	1	0	0	0	15122	942	33	1	1153	1	SPTLC1	9	94843181	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4559625	94843181	46370250	274	35264										
FOXE1	2304	broad.mit.edu	37	chr9	100616407	100616407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggccatcgcgcacgcgcccGagcgccgcctcacgctgggc	14	19	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:100616407G>A	uc004axu.2	+	1	871	c.211G>A	c.(211-213)GAG>AAG	p.E71K		NM_004473	NP_004464	O00358	FOXE1_HUMAN	forkhead box E1	71	Fork-head.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		Acute lymphoblastic leukemia(62;0.158)				GCACGCGCCCGAGCGCCGCCT	0.572													0	0	0	0.00245	0	12	14										A	100616407	G	A	100616407	3	1	117	1	0	0	0	0	1	0	0	0	6003	1059	37	1	213	1	FOXE1	9	100616407	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5773226	100616407	40597024	275	35265										
TMEM38B	55151	broad.mit.edu	37	chr9	108536171	108536171	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catgatgactacacagacttCtactatgacatttgctcctt	5	11	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:108536171C>T	uc004bcu.1	+	6	803	c.686C>T	c.(685-687)TCT>TTT	p.S229F	TMEM38B_uc010mtn.1_3'UTR	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	229	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						ACACAGACTTCTACTATGACA	0.358													0	0	0	0.009535	0	23	73										T	108536171	C	T	108536171	3	4	117	1	0	0	0	0	1	0	0	0	16157	913	32	1	708	1	TMEM38B	9	108536171	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7919764	108536171	32677260	276	35266										
IKBKAP	8518	broad.mit.edu	37	chr9	111659293	111659293	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggggttgtcttctttacatGagatgtaagtatggataggc	13	4	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:111659293G>T	uc004bdm.3	-	24	3047	c.2527C>A	c.(2527-2529)CAT>AAT	p.H843N	IKBKAP_uc004bdl.2_Missense_Mutation_p.H494N|IKBKAP_uc011lwc.1_Missense_Mutation_p.H729N|IKBKAP_uc010mtq.2_Missense_Mutation_p.H494N	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	843					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						TTCTTTACATGAGATGTAAGT	0.433													1	0	3.8784e-16	0.012319	4.12237e-16	17	76										T	111659293	G	T	111659293	3	4	117	1	0	0	0	0	1	0	0	0	7610	1290	45	3	1527	3	IKBKAP	9	111659293	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3123122	111659293	29554138	277	35267										
ZFP37	7539	broad.mit.edu	37	chr9	115805645	115805645	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcacatgttcggtaagagatGagttatacctaaaagacttc	8	7	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:115805645G>A	uc004bgm.1	-	4	1281	c.1253C>T	c.(1252-1254)TCA>TTA	p.S418L	ZFP37_uc011lwz.1_Missense_Mutation_p.S433L|ZFP37_uc011lxa.1_Missense_Mutation_p.S419L	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	418	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTAAGAGATGAGTTATACCT	0.388													0	0	0	0.00361	0	49	36										A	115805645	G	A	115805645	3	1	117	1	0	0	0	0	1	0	0	0	17645	1294	45	1	643	1	ZFP37	9	115805645	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4146352	115805645	25407786	278	35268										
ZFP37	7539	broad.mit.edu	37	chr9	115806039	115806039	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atagggtttcacacaagcttGaggtttttcatgcttagtag	10	6	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:115806039G>A	uc004bgm.1	-	4	887	c.859C>T	c.(859-861)CAA>TAA	p.Q287*	ZFP37_uc011lwz.1_Nonsense_Mutation_p.Q302*|ZFP37_uc011lxa.1_Nonsense_Mutation_p.Q288*	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	287						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ACACAAGCTTGAGGTTTTTCA	0.403													0	0	0	0.00361	0	61	51										A	115806039	G	A	115806039	4	1	117	1	0	0	0	0	0	1	0	0	17645	1299	45	1	1037	1	ZFP37	9	115806039	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	394	115806039	25407392	279	35269										
TRIM32	22954	broad.mit.edu	37	chr9	119461344	119461344	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcaatgaactgccaggggctGattggtgtgactgacagcta	14	8	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:119461344G>A	uc004bjx.2	+	2	1481	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Silent_p.L441L	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	441	NHL 2.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GCCAGGGGCTGATTGGTGTGA	0.547									Bardet-Biedl_syndrome				0	0	0	0.00361	0	63	211										A	119461344	G	A	119461344	2	1	117	1	0	0	0	0	0	0	0	1	16503	1277	45	1		1	TRIM32	9	119461344	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3655305	119461344	21752087	280	35270										
DAB2IP	153090	broad.mit.edu	37	chr9	124535708	124535708	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgggccccagtacccgcctGaggcagcagtcctcttcctc	11	17	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:124535708G>A	uc004bln.2	+	12	2886	c.2817G>A	c.(2815-2817)CTG>CTA	p.L939L	DAB2IP_uc004blo.2_Silent_p.L843L|DAB2IP_uc004blp.2_Silent_p.L372L	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	967					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						GTACCCGCCTGAGGCAGCAGT	0.657													0	0	0	0.012319	0	16	8										A	124535708	G	A	124535708	2	1	117	1	0	0	0	0	0	0	0	1	4219	1277	45	1		1	DAB2IP	9	124535708	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5074364	124535708	16677723	281	35271										
LMX1B	4010	broad.mit.edu	37	chr9	129455807	129455807	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctctctctgagccaggtccGagagacactggcagctgaga	12	13	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:129455807G>C	uc004bqj.2	+	5	727	c.677G>C	c.(676-678)CGA>CCA	p.R226P	LMX1B_uc004bqi.2_Missense_Mutation_p.R226P|LMX1B_uc011maa.1_Missense_Mutation_p.R226P	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	226	Homeobox.		R -> P (in NPS).		dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGCCAGGTCCGAGAGACACTG	0.612									Nail-Patella_Syndrome				0	0	0	0.00361	0	48	39										C	129455807	G	C	129455807	3	2	117	1	0	0	0	0	1	0	0	0	8862	1058	37	1	764	1	LMX1B	9	129455807	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4920099	129455807	11757624	282	35272										
RALGPS1	9649	broad.mit.edu	37	chr9	129728131	129728131	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgctctccacagggcagcagCagctcggactctctggaggg	14	13	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:129728131C>A	uc004bqo.1	+	3	333	c.66C>A	c.(64-66)AGC>AGA	p.S22R	RALGPS1_uc011mab.1_Missense_Mutation_p.S22R|RALGPS1_uc011mac.1_Missense_Mutation_p.S22R|RALGPS1_uc004bqq.3_Missense_Mutation_p.S22R	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	22	Poly-Ser.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						AGGGCAGCAGCAGCTCGGACT	0.542													1	0	0.000375601	0.00278	0.000383754	19	77										A	129728131	C	A	129728131	3	1	117	1	0	0	0	0	1	0	0	0	13017	709	25	4	72	4	RALGPS1	9	129728131	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	272324	129728131	11485300	283	35273										
RALGPS1	9649	broad.mit.edu	37	chr9	129958857	129958857	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctagagtcccgcagcccccGaaggggcctggctctgacct	12	17	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:129958857G>A	uc004bqo.1	+	13	1409	c.1142G>A	c.(1141-1143)CGA>CAA	p.R381Q	RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	381					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						CGCAGCCCCCGAAGGGGCCTG	0.577													0	0	0	0.004878	0	31	75										A	129958857	G	A	129958857	3	1	117	1	0	0	0	0	1	0	0	0	13017	1058	37	1	1188	1	RALGPS1	9	129958857	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	230726	129958857	11254574	284	35274										
GARNL3	84253	broad.mit.edu	37	chr9	130152935	130152935	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tccaggcctctcggatgaagGtggacccaagtcagaaggag	14	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:130152935G>T	uc011mae.1	+	27	3160	c.2759G>T	c.(2758-2760)GGT>GTT	p.G920V	GARNL3_uc011mad.1_Missense_Mutation_p.G898V|GARNL3_uc010mxi.2_Missense_Mutation_p.G150V	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	920					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCGGATGAAGGTGGACCCAAG	0.537													1	0	2.70572e-37	0.00361	2.94236e-37	79	71										T	130152935	G	T	130152935	3	4	117	1	0	0	0	0	1	0	0	0	6241	1261	44	4	2865	4	GARNL3	9	130152935	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	194078	130152935	11060496	285	35275										
LRSAM1	90678	broad.mit.edu	37	chr9	130265177	130265177	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccgcatctaccacagcagctGagtgctgcccgcccacctgg	10	18	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:130265177G>A	uc004brb.1	+	26	2516	c.2171G>A	c.(2170-2172)TGA>TAA	p.*724*	LRSAM1_uc010mxk.1_Silent_p.*697*|LRSAM1_uc004brc.1_Silent_p.*724*|LRSAM1_uc004brd.1_Silent_p.*724*|LRSAM1_uc004bre.1_Silent_p.*304*|LRSAM1_uc004brg.1_Silent_p.*155*	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	724					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						CACAGCAGCTGAGTGCTGCCC	0.697													0	0	0	0.00308	0	8	6										A	130265177	G	A	130265177	2	1	117	1	0	0	0	0	0	0	0	1	9043	1285	45	1		1	LRSAM1	9	130265177	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	112242	130265177	10948254	286	35276										
TTC16	158248	broad.mit.edu	37	chr9	130489656	130489656	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgaggagctgaaggccacccCtgagattccgcaggtaaaac	12	12	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:130489656C>T	uc004brq.1	+	12	1743	c.1676C>T	c.(1675-1677)CCT>CTT	p.P559L	PTRH1_uc011mah.1_5'Flank|TTC16_uc011mai.1_Missense_Mutation_p.P546L|TTC16_uc004brr.1_Missense_Mutation_p.P409L|TTC16_uc010mxn.1_Missense_Mutation_p.P155L	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	559							binding				0						AAGGCCACCCCTGAGATTCCG	0.493													0	0	0	0.007413	0	15	11										T	130489656	C	T	130489656	3	4	117	1	0	0	0	0	1	0	0	0	16680	681	24	2	1722	2	TTC16	9	130489656	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	224479	130489656	10723775	287	35277										
SARDH	1757	broad.mit.edu	37	chr9	136531911	136531911	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcgatggtcttgtcgatggcGaacccaaagtcagccctccg	12	13	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:136531911G>A	uc004cep.3	-	20	2711	c.2577C>T	c.(2575-2577)TTC>TTT	p.F859F	SARDH_uc004ceo.2_Silent_p.F859F|SARDH_uc011mdn.1_Silent_p.F859F|SARDH_uc011mdo.1_Silent_p.F691F|SARDH_uc004cen.2_Silent_p.F309F	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	859					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGTCGATGGCGAACCCAAAGT	0.597													0	0	0	0.004672	0	3	11										A	136531911	G	A	136531911	2	1	117	1	0	0	0	0	0	0	0	1	13841	1049	37	1		1	SARDH	9	136531911	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6042255	136531911	4681520	288	35278										
KCNT1	57582	broad.mit.edu	37	chr9	138606490	138606490	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agatgagcgacctggactccGaggtgctgcccttgccgccg	14	14	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:138606490G>A	uc011mdq.1	+	2	252	c.178G>A	c.(178-180)GAG>AAG	p.E60K	KCNT1_uc011mdr.1_5'UTR|KCNT1_uc010nbf.2_Intron	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	60						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CCTGGACTCCGAGGTGCTGCC	0.716													0	0	0	0.004656	0	19	39										A	138606490	G	A	138606490	3	1	117	1	0	0	0	0	1	0	0	0	8091	1059	37	1	184	1	KCNT1	9	138606490	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2074579	138606490	2606941	289	35279										
C9orf142	286257	broad.mit.edu	37	chr9	139887394	139887394	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tagaaagcccgttttggcctGagtgcggctgaggacatcac	13	10	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr9:139887394G>C	uc004cki.2	+	3	224	c.198G>C	c.(196-198)CTG>CTC	p.L66L		NM_183241	NP_899064	Q9BUH6	CI142_HUMAN	hypothetical protein LOC286257	66											0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GTTTTGGCCTGAGTGCGGCTG	0.662													0	0	0	0.004878	0	30	130										C	139887394	G	C	139887394	2	2	117	1	0	0	0	0	0	0	0	1	2461	1277	45	1		1	C9orf142	9	139887394	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1280904	139887394	1326037	290	35280										
PFKP	5214	broad.mit.edu	37	chr10	3155563	3155563	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacctgccttctgttttgcaGaccaattgcaacgtagctgt	8	12	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:3155563G>A	uc001igp.2	+	13	1261	c.1225_splice	c.e13-1	p.T409_splice	PFKP_uc001igq.2_Splice_Site_p.T401_splice|PFKP_uc009xhr.2_Splice_Site_p.T371_splice|PFKP_uc009xhs.1_Splice_Site_p.T193_splice|PFKP_uc009xht.2_Splice_Site_p.T147_splice|PFKP_uc009xhu.2_5'Flank	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet						glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CTGTTTTGCAGACCAATTGCA	0.607													0	0	0	0.001984	0	6	35										A	3155563	G	A	3155563	5	1	117	1	0	0	0	0	0	0	1	0	11766	956	33	1	1274	1	PFKP	10	3155563	Splice_Site	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		3155563	132379184	291	35281										
FAM171A1	221061	broad.mit.edu	37	chr10	15326105	15326105	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgcacctttaacgtcacctCtggaggtagagaaagcacaa	10	10	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:15326105C>G	uc001iob.2	-	2	105	c.98_splice	c.e2-1	p.E33_splice		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor							integral to membrane				ovary(2)|breast(1)|skin(1)	4						AACGTCACCTCTGGAGGTAGA	0.527													0	0	0	0.003163	0	15	65										G	15326105	C	G	15326105	5	3	117	1	0	0	0	0	0	0	1	0	5490	927	32	1	2603	1	FAM171A1	10	15326105	Splice_Site	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	12170542	15326105	120208642	292	35282										
YME1L1	10730	broad.mit.edu	37	chr10	27437904	27437904	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgagaaactgacactccactGagagaaacagaagtgttttt	9	7	0	5			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:27437904G>A	uc001iti.2	-	2	281	c.99C>T	c.(97-99)CTC>CTT	p.L33L	YME1L1_uc001itj.2_Silent_p.L33L|YME1L1_uc010qdl.1_Silent_p.L33L|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Silent_p.L33L	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	33					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						ACACTCCACTGAGAGAAACAG	0.408													0	0	0	0.00361	0	49	199										A	27437904	G	A	27437904	2	1	117	1	0	0	0	0	0	0	0	1	17484	1277	45	1		1	YME1L1	10	27437904	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12111799	27437904	108096843	293	35283										
YME1L1	10730	broad.mit.edu	37	chr10	27437951	27437951	+	Missense_Mutation	SNP	G	G	A													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atggaaggcattgatgagatGactcagaggaactgtaacct							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:27437951G>A	uc001iti.2	-	2	234	c.52C>T	c.(52-54)CAT>TAT	p.H18Y	YME1L1_uc001itj.2_Missense_Mutation_p.H18Y|YME1L1_uc010qdl.1_Missense_Mutation_p.H18Y|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Missense_Mutation_p.H18Y	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	18					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTGATGAGATGACTCAGAGGA	0.343													0	0	0	0.00361	0	33	157										A	27437951	G	A	27437951	3	1	117	1	0	0	0	0	1	0	0	0	17484	1290	45	1	2345	1	YME1L1	10	27437951	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	47	27437951	108096796	294	35284	183	2								
YME1L1	10730	broad.mit.edu	37	chr10	27437957	27437957	+	Silent	SNP	G	G	A													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcattgatgagatgactcaGaggaactgtaacctagaaaa							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:27437957G>A	uc001iti.2	-	2	228	c.46C>T	c.(46-48)CTG>TTG	p.L16L	YME1L1_uc001itj.2_Silent_p.L16L|YME1L1_uc010qdl.1_Silent_p.L16L|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Silent_p.L16L	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	16					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						AGATGACTCAGAGGAACTGTA	0.338													0	0	0	0.006999	0	28	139										A	27437957	G	A	27437957	2	1	117	1	0	0	0	0	0	0	0	1	17484	933	33	1		1	YME1L1	10	27437957	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6	27437957	108096790	295	35285	183	2								
WAC	51322	broad.mit.edu	37	chr10	28897142	28897142	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atcaggagacaaacccgtatCacattcttgcacaactcctt	5	13	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:28897142C>G	uc001iuf.2	+	8	1032	c.947C>G	c.(946-948)TCA>TGA	p.S316*	WAC_uc001iud.2_Nonsense_Mutation_p.S271*|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Nonsense_Mutation_p.S271*|WAC_uc001iug.2_Nonsense_Mutation_p.S213*|WAC_uc001iuh.2_Nonsense_Mutation_p.S271*	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	316					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						AAACCCGTATCACATTCTTGC	0.433													0	0	0	0.00361	0	66	107										G	28897142	C	G	28897142	4	3	117	1	0	0	0	0	0	1	0	0	17244	838	29	1	977	1	WAC	10	28897142	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1459185	28897142	106637605	296	35286										
PARD3	56288	broad.mit.edu	37	chr10	34805961	34805961	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acttgttgcttggtaaggctGaaaggctgagacattgttgg	14	5	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:34805961G>A	uc010qej.1	-	3	349	c.349C>T	c.(349-351)CAG>TAG	p.Q117*	PARD3_uc010qek.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qel.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qem.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qen.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qeo.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qep.1_Nonsense_Mutation_p.Q117*|PARD3_uc010qeq.1_Nonsense_Mutation_p.Q117*|PARD3_uc001ixp.1_5'UTR|PARD3_uc001ixq.1_Nonsense_Mutation_p.Q117*|PARD3_uc001ixr.1_Nonsense_Mutation_p.Q117*|PARD3_uc001ixt.1_5'UTR|PARD3_uc001ixu.1_Nonsense_Mutation_p.Q117*	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	117					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TGGTAAGGCTGAAAGGCTGAG	0.473													0	0	0	0.00361	0	46	78										A	34805961	G	A	34805961	4	1	117	1	0	0	0	0	0	1	0	0	11443	1299	45	1	3848	1	PARD3	10	34805961	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5908819	34805961	100728786	297	35287										
PCDH15	65217	broad.mit.edu	37	chr10	55569091	55569091	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tctttatcttcttcctcaagGcgtctctgccactcttcacc	4	16	7	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:55569091G>A	uc010qhs.1	-	37	5129	c.4734C>T	c.(4732-4734)CGC>CGT	p.R1578R	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Silent_p.R1571R|PCDH15_uc010qhu.1_3'UTR	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTTCCTCAAGGCGTCTCTGCC	0.428										HNSCC(58;0.16)			0	0	0	0.010729	0	9	31										A	55569091	G	A	55569091	2	1	117	1	0	0	0	0	0	0	0	1	11511	1190	42	2		2	PCDH15	10	55569091	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	20763130	55569091	79965656	298	35288										
DDX21	9188	broad.mit.edu	37	chr10	70733307	70733307	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttttacttcaataggatgtaGagtcctacattcatcgatcc	6	9	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:70733307G>C	uc001jov.1	+	10	1645	c.1555G>C	c.(1555-1557)GAG>CAG	p.E519Q	DDX21_uc001jow.1_Missense_Mutation_p.E451Q	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	519	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						ATAGGATGTAGAGTCCTACAT	0.443													0	0	0	0.010771	0	35	22										C	70733307	G	C	70733307	3	2	117	1	0	0	0	0	1	0	0	0	4349	943	33	1	1593	1	DDX21	10	70733307	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	15164216	70733307	64801440	299	35289										
HKDC1	80201	broad.mit.edu	37	chr10	70992797	70992797	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aatatgtagctgactgtctgGcagatttcatgaagaccaaa	9	7	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:70992797G>T	uc001jpf.3	+	4	536	c.403G>T	c.(403-405)GCA>TCA	p.A135S	HKDC1_uc010qje.1_5'UTR	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	135					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						TGACTGTCTGGCAGATTTCAT	0.468													1	0	7.93312e-07	0.00245	8.15589e-07	14	48										T	70992797	G	T	70992797	3	4	117	1	0	0	0	0	1	0	0	0	7193	1203	42	4	417	4	HKDC1	10	70992797	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	259490	70992797	64541950	300	35290										
ZMIZ1	57178	broad.mit.edu	37	chr10	81052006	81052026	+	In_Frame_Del	DEL	GCAGCAGCGGCAGTGGCAGCA	GCAGCAGCGGCAGTGGCAGCA	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctcagcccgcggcagccgctGcagcagcggcagtggcagca							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:81052006_81052026delGCAGCAGCGGCAGTGGCAGCA	uc001kaf.2	+	11	1422_1442	c.850_870delGCAGCAGCGGCAGTGGCAGCA	c.(850-870)GCAGCAGCGGCAGTGGCAGCAdel	p.AAAAVAA284del	ZMIZ1_uc001kag.2_In_Frame_Del_p.AAAAVAA160del|ZMIZ1_uc001kah.1_In_Frame_Del_p.AAAAVAA160del	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	284_290	Ala-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			ggcagccgctgcagcagcggcagtggcagcagcagcagcCA	0.511																		48	82	---	---								-	81052026	GCAGCAGCGGCAGTGGCAGCA	-	81052006	7	5	117	1	0	1	0	1	0	0	0	0	17693	1319	46	0	876	0	ZMIZ1	10	81052006	In_Frame_Del	DEL	GCAGCAGCGGCAGTGGCAGCA	TCGA-GV-A3JZ-01A-11D-A21A-08	10059209	81052006	54482741	301	35291										
COX15	1355	broad.mit.edu	37	chr10	101480768	101480768	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gagggccgtaaggaacaccaGacctgctgttccatgagcaa	12	11	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:101480768G>C	uc001kqb.3	-	6	1425	c.808C>G	c.(808-810)CTG>GTG	p.L270V	COX15_uc001kqc.3_Missense_Mutation_p.L270V|COX15_uc010qpj.1_Missense_Mutation_p.L91V	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	270	Helical; (Potential).				heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		AGGAACACCAGACCTGCTGTT	0.463													0	0	0	0.006214	0	7	13										C	101480768	G	C	101480768	3	2	117	1	0	0	0	0	1	0	0	0	3764	933	33	1	510	1	COX15	10	101480768	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	20428762	101480768	34053979	302	35292										
ABCC2	1244	broad.mit.edu	37	chr10	101567904	101567904	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caatattttggatgcacaaaAggccttcacctccattaccc	5	13	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:101567904A>C	uc001kqf.2	+	13	1872	c.1733A>C	c.(1732-1734)AAG>ACG	p.K578T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	578	ABC transmembrane type-1 1.|Extracellular (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GATGCACAAAAGGCCTTCACC	0.463													0	0	0	0.008871	0	20	107										C	101567904	A	C	101567904	3	2	117	1	0	0	0	0	1	0	0	0	53	72	3	5	1783	5	ABCC2	10	101567904	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	87136	101567904	33966843	303	35293										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118365052	118365052	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agatcactgtgcaaaagggaGaagagaagacagtgtatgta	13	4	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:118365052G>C	uc001lco.1	+	12	1345	c.1327G>C	c.(1327-1329)GAA>CAA	p.E443Q	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.E443Q	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	443	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GCAAAAGGGAGAAGAGAAGAC	0.403													0	0	0	0.00361	0	38	44										C	118365052	G	C	118365052	3	2	117	1	0	0	0	0	1	0	0	0	12150	943	33	1	1369	1	PNLIPRP1	10	118365052	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	16797148	118365052	17169695	304	35294										
SLC18A2	6571	broad.mit.edu	37	chr10	119014792	119014792	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttctctccctgcagtgggCccccccttcgggagtgtgct	11	16	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:119014792C>A	uc001ldd.1	+	7	736	c.705C>A	c.(703-705)GGC>GGA	p.G235G	SLC18A2_uc009xyy.1_Silent_p.G32G	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	235	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CTGCAGTGGGCCCCCCCTTCG	0.572													1	0	6.33695e-27	0.007835	6.8685e-27	33	66										A	119014792	C	A	119014792	2	1	117	1	0	0	0	0	0	0	0	1	14426	726	26	4		4	SLC18A2	10	119014792	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	649740	119014792	16519955	305	35295										
C10orf137	26098	broad.mit.edu	37	chr10	127413965	127413965	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agaggaagaaaaagagcaaaGagcactggtatcaaaaggca	12	5	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:127413965G>C	uc001liq.1	+	5	882	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	C10orf137_uc001lin.2_Missense_Mutation_p.E197Q|C10orf137_uc001lio.1_Missense_Mutation_p.E197Q|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAAGAGCAAAGAGCACTGGTA	0.348													0	0	0	0.008291	0	8	21										C	127413965	G	C	127413965	3	2	117	1	0	0	0	0	1	0	0	0	1594	943	33	1	607	1	C10orf137	10	127413965	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8399173	127413965	8120782	306	35296										
PTPRE	5791	broad.mit.edu	37	chr10	129877885	129877885	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acattttggagcgagtaaaaGccgagggacttttagatgta	12	5	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:129877885G>T	uc001lkb.2	+	20	2233	c.1954G>T	c.(1954-1956)GCC>TCC	p.A652S	PTPRE_uc009yat.2_Missense_Mutation_p.A663S|PTPRE_uc009yau.2_Missense_Mutation_p.A652S|PTPRE_uc001lkd.2_Missense_Mutation_p.A594S|PTPRE_uc010quq.1_Intron	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	652	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GCGAGTAAAAGCCGAGGGACT	0.458													1	0	0.004672	0.004672	0.00472216	3	40										T	129877885	G	T	129877885	3	4	117	1	0	0	0	0	1	0	0	0	12800	971	34	4	2063	4	PTPRE	10	129877885	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2463920	129877885	5656862	307	35297										
KNDC1	85442	broad.mit.edu	37	chr10	135038330	135038330	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggccaacttccaccaggtctCcagcgagaagcactcacgga	10	15	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr10:135038330C>G	uc001llz.1	+	30	5187	c.5186C>G	c.(5185-5187)TCC>TGC	p.S1729C		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1729					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CACCAGGTCTCCAGCGAGAAG	0.577													0	0	0	0.011902	0	36	10										G	135038330	C	G	135038330	3	3	117	1	0	0	0	0	1	0	0	0	8426	855	30	1	5304	1	KNDC1	10	135038330	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5160445	135038330	496417	308	35298										
MUC5B	727897	broad.mit.edu	37	chr11	1272679	1272679	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agccgagcactatagccaccGtgatggtgcccaccggttcc	11	15	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:1272679G>A	uc009ycr.1	+	52	15661	c.15535G>A	c.(15535-15537)GTG>ATG	p.V5179M	MUC5B_uc001ltb.2_Missense_Mutation_p.V4860M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4857	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TATAGCCACCGTGATGGTGCC	0.632													0	0	0	0.004289	0	32	138										A	1272679	G	A	1272679	3	1	117	1	0	0	0	0	1	0	0	0	9979	1145	40	2	14700	2	MUC5B	11	1272679	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		1272679	133733837	309	35299										
OR52I1	390037	broad.mit.edu	37	chr11	4616239	4616239	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgaccactccaacctgggttCatgaacacaatatctgttca	6	12	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:4616239C>G	uc010qyi.1	+	1	971	c.971C>G	c.(970-972)TCA>TGA	p.S324*		NM_001005169	NP_001005169	Q8NGK6	O52I1_HUMAN	olfactory receptor, family 52, subfamily I,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;7.98e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AACCTGGGTTCATGAACACAA	0.433													0	0	0	0.00632	0	24	89										G	4616239	C	G	4616239	4	3	117	1	0	0	0	0	0	1	0	0	11120	838	29	1	973	1	OR52I1	11	4616239	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3343560	4616239	130390277	310	35300										
PIK3C2A	5286	broad.mit.edu	37	chr11	17172072	17172072	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgtaaaagtaactggtagctGaaatccttcaatgtcaatgg	9	7	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:17172072G>A	uc001mmq.3	-	3	1366	c.1300C>T	c.(1300-1302)CAG>TAG	p.Q434*	PIK3C2A_uc009ygu.1_5'UTR|PIK3C2A_uc010rcw.1_Nonsense_Mutation_p.Q54*|PIK3C2A_uc001mmr.3_RNA|PIK3C2A_uc010rcx.1_Nonsense_Mutation_p.Q434*|PIK3C2A_uc009ygv.1_Nonsense_Mutation_p.Q434*	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	434					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	ACTGGTAGCTGAAATCCTTCA	0.403													0	0	0	0.008361	0	25	102										A	17172072	G	A	17172072	4	1	117	1	0	0	0	0	0	1	0	0	11909	1299	45	1	3880	1	PIK3C2A	11	17172072	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12555833	17172072	117834444	311	35301										
CCDC73	493860	broad.mit.edu	37	chr11	32705116	32705116	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcttctgtaaagagtatttaGaaaccttgaaaaataagggg	9	4	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:32705116G>C	uc001mtv.2	-	7	439	c.395C>G	c.(394-396)TCT>TGT	p.S132C	CCDC73_uc001mtw.1_Missense_Mutation_p.S132C|CCDC73_uc009yjt.2_Missense_Mutation_p.S132C	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	132	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					AGAGTATTTAGAAACCTTGAA	0.328													0	0	0	0.004878	0	29	7										C	32705116	G	C	32705116	3	2	117	1	0	0	0	0	1	0	0	0	2846	942	33	1	2892	1	CCDC73	11	32705116	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	15533044	32705116	102301400	312	35302										
AMBRA1	55626	broad.mit.edu	37	chr11	46529801	46529801	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaccctggttgtctgaggaaGaggaggaggtggaagaacgg	19	5	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:46529801G>C	uc010rgu.1	-	9	2639	c.2279C>G	c.(2278-2280)TCT>TGT	p.S760C	AMBRA1_uc010rgt.1_Missense_Mutation_p.S326C|AMBRA1_uc009ylc.1_Missense_Mutation_p.S731C|AMBRA1_uc001ncu.1_Missense_Mutation_p.S670C|AMBRA1_uc001ncv.2_Missense_Mutation_p.S763C|AMBRA1_uc001ncw.2_Missense_Mutation_p.S641C|AMBRA1_uc001ncx.2_Intron	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	760					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GTCTGAGGAAGAGGAGGAGGT	0.517													0	0	0	0.008361	0	24	67										C	46529801	G	C	46529801	3	2	117	1	0	0	0	0	1	0	0	0	565	942	33	1	1657	1	AMBRA1	11	46529801	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	13824685	46529801	88476715	313	35303										
OR4A5	81318	broad.mit.edu	37	chr11	51412330	51412330	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacatgacaaataatgctttTtgcacaccaggatcctgaga	7	9	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:51412330T>C	uc001nhi.1	-	1	66	c.66A>G	c.(64-66)CAA>CAG	p.Q22Q		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				ATAATGCTTTTTGCACACCAG	0.428													0	0	0	0.001368	0	10	35										C	51412330	T	C	51412330	2	2	117	1	0	0	0	0	0	0	0	1	11043	1838	64	5		5	OR4A5	11	51412330	Silent	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	4882529	51412330	83594186	314	35304										
OR4D11	219986	broad.mit.edu	37	chr11	59271357	59271357	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcatgacacagatatttctCttccacctccttggtggggc	9	12	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:59271357C>T	uc001noa.1	+	1	309	c.309C>T	c.(307-309)CTC>CTT	p.L103L		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGATATTTCTCTTCCACCTCC	0.468													0	0	0	0.00361	0	109	59										T	59271357	C	T	59271357	2	4	117	1	0	0	0	0	0	0	0	1	11055	900	32	1		1	OR4D11	11	59271357	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7859027	59271357	75735159	315	35305										
STX3	6809	broad.mit.edu	37	chr11	59560641	59560641	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caacccggccatcttcacttCtggggtgagtgccctgtgtg	12	13	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:59560641C>T	uc001nog.2	+	7	726	c.536C>T	c.(535-537)TCT>TTT	p.S179F	STX3_uc010rkx.1_Missense_Mutation_p.S179F|STX3_uc010rky.1_Missense_Mutation_p.S82F|STX3_uc009ymt.1_Missense_Mutation_p.S82F	NM_004177	NP_004168	Q13277	STX3_HUMAN	syntaxin 3	179	Cytoplasmic (Potential).				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			ovary(2)	2						ATCTTCACTTCTGGGGTGAGT	0.562													0	0	0	0.002299	0	20	14										T	59560641	C	T	59560641	3	4	117	1	0	0	0	0	1	0	0	0	15345	913	32	1	562	1	STX3	11	59560641	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	289284	59560641	75445875	316	35306										
TMEM132A	54972	broad.mit.edu	37	chr11	60702234	60702234	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcccggtgtcacctccattGaggtaagcagctggggacca	13	12	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:60702234G>A	uc001nqj.2	+	9	2027	c.1834G>A	c.(1834-1836)GAG>AAG	p.E612K	TMEM132A_uc001nqi.2_Missense_Mutation_p.E613K|TMEM132A_uc001nqm.2_5'UTR	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	612	Binds to HSPA5/GRP78 (By similarity).|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CACCTCCATTGAGGTAAGCAG	0.667													0	0	0	0.006999	0	34	19										A	60702234	G	A	60702234	3	1	117	1	0	0	0	0	1	0	0	0	16042	1291	45	1	1871	1	TMEM132A	11	60702234	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1141593	60702234	74304282	317	35307										
AHNAK	79026	broad.mit.edu	37	chr11	62293224	62293224	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gggcatcttcaggtgccagtCtggaccctgaacattaacat	10	11	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62293224C>G	uc001ntl.2	-	5	8965	c.8665G>C	c.(8665-8667)GAC>CAC	p.D2889H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2889					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGGTGCCAGTCTGGACCCTGA	0.517													0	0	0	0.00361	0	74	257										G	62293224	C	G	62293224	3	3	117	1	0	0	0	0	1	0	0	0	414	913	32	1	9127	1	AHNAK	11	62293224	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1590990	62293224	72713292	318	35308			1	165		4	4	2087	C		8.419733e-06
AHNAK	79026	broad.mit.edu	37	chr11	62293741	62293741	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccttcactttgggtcctttCaggtttaagtcaatatcagg	8	10	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62293741C>T	uc001ntl.2	-	5	8448	c.8148G>A	c.(8146-8148)CTG>CTA	p.L2716L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2716					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGTCCTTTCAGGTTTAAGT	0.473													0	0	0	0.00361	0	58	181										T	62293741	C	T	62293741	2	4	117	1	0	0	0	0	0	0	0	1	414	813	29	1		1	AHNAK	11	62293741	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	517	62293741	72712775	319	35309			1	165		4	4	2087	C		8.419733e-06
AHNAK	79026	broad.mit.edu	37	chr11	62293851	62293851	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggtccttcaatgttaacatCagggccttcaatgtccactt	7	11	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62293851C>G	uc001ntl.2	-	5	8338	c.8038G>C	c.(8038-8040)GAT>CAT	p.D2680H	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2680					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ATGTTAACATCAGGGCCTTCA	0.498													0	0	0	0.00361	0	53	159										G	62293851	C	G	62293851	3	3	117	1	0	0	0	0	1	0	0	0	414	826	29	1	9754	1	AHNAK	11	62293851	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	110	62293851	72712665	320	35310			1	165		4	4	2087	C		8.419733e-06
AHNAK	79026	broad.mit.edu	37	chr11	62295310	62295310	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctttgactttggggcctttCaagtttaagttcacatcagg	9	9	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62295310C>G	uc001ntl.2	-	5	6879	c.6579G>C	c.(6577-6579)TTG>TTC	p.L2193F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2193					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGGCCTTTCAAGTTTAAGT	0.473													0	0	0	0.00361	0	106	352										G	62295310	C	G	62295310	3	3	117	1	0	0	0	0	1	0	0	0	414	825	29	1	11213	1	AHNAK	11	62295310	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1459	62295310	72711206	321	35311			1	165		4	4	2087	C		8.419733e-06
EEF1G	1937	broad.mit.edu	37	chr11	62327634	62327634	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgacactggcgaaggcattCttcctcagcttgtccagtcg	10	12	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:62327634C>G	uc001ntm.1	-	9	1208	c.1062G>C	c.(1060-1062)AAG>AAC	p.K354N	EEF1G_uc010rlw.1_Missense_Mutation_p.K404N|EEF1G_uc001ntn.1_Missense_Mutation_p.K234N	NM_001404	NP_001395	P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1	354	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						CGAAGGCATTCTTCCTCAGCT	0.517													0	0	0	0.011902	0	45	19										G	62327634	C	G	62327634	3	3	117	1	0	0	0	0	1	0	0	0	4928	912	32	1	259	1	EEF1G	11	62327634	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	32324	62327634	72678882	322	35312										
COX8A	1351	broad.mit.edu	37	chr11	63742235	63742235	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccgcgcgccaagatccattCgttgccgccggaggggaagc	15	14	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:63742235C>G	uc001nye.2	+	1	157	c.83C>G	c.(82-84)TCG>TGG	p.S28W		NM_004074	NP_004065	P10176	COX8A_HUMAN	cytochrome c oxidase subunit VIIIa precursor	28	Mitochondrial matrix (By similarity).				respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity				0						AAGATCCATTCGTTGCCGCCG	0.687													0	0	0	0.001368	0	12	20										G	63742235	C	G	63742235	3	3	117	1	0	0	0	0	1	0	0	0	3785	893	31	1	85	1	COX8A	11	63742235	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1414601	63742235	71264281	323	35313										
CTTN	2017	broad.mit.edu	37	chr11	70281143	70281143	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttccccagcgggcgatgatGagatctcatttgaccctgat	10	12	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:70281143G>A	uc001opv.3	+	18	1734	c.1528G>A	c.(1528-1530)GAG>AAG	p.E510K	CTTN_uc001opu.2_Missense_Mutation_p.E473K|CTTN_uc001opw.3_Missense_Mutation_p.E473K|CTTN_uc010rqm.1_Missense_Mutation_p.E194K|CTTN_uc001opx.2_Missense_Mutation_p.E194K	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	510	SH3.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGGCGATGATGAGATCTCATT	0.557													0	0	0	0.00361	0	42	145										A	70281143	G	A	70281143	3	1	117	1	0	0	0	0	1	0	0	0	4044	1291	45	1	1590	1	CTTN	11	70281143	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6538908	70281143	64725373	324	35314										
TSKU	25987	broad.mit.edu	37	chr11	76506762	76506762	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtggagaccttcggccttttCgacagcttcagcctgactcg	11	13	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:76506762C>T	uc001oxt.2	+	2	274	c.102C>T	c.(100-102)TTC>TTT	p.F34F		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	34	LRRNT.					extracellular region					0	Ovarian(111;0.112)					TCGGCCTTTTCGACAGCTTCA	0.662													0	0	0	0.003271	0	32	87										T	76506762	C	T	76506762	2	4	117	1	0	0	0	0	0	0	0	1	16624	883	31	1		1	TSKU	11	76506762	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6225619	76506762	58499754	325	35315										
TSKU	25987	broad.mit.edu	37	chr11	76507100	76507100	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caaccagctccgggaggtctCagtgtctgccttcacgacgc	11	15	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:76507100C>T	uc001oxt.2	+	2	612	c.440C>T	c.(439-441)TCA>TTA	p.S147L		NM_015516	NP_056331	Q8WUA8	TSK_HUMAN	tsukushin precursor	147	LRR 4.					extracellular region					0	Ovarian(111;0.112)					CGGGAGGTCTCAGTGTCTGCC	0.652													0	0	0	0.007291	0	27	117										T	76507100	C	T	76507100	3	4	117	1	0	0	0	0	1	0	0	0	16624	838	29	1	442	1	TSKU	11	76507100	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	338	76507100	58499416	326	35316										
ODZ4	26011	broad.mit.edu	37	chr11	78381538	78381538	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcgtcacagaagagaggcggTcattcttgtcgaactcaaag	11	9	4	2	rs76161186		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:78381538T>C	uc001ozl.3	-	32	6315	c.5852A>G	c.(5851-5853)GAC>GGC	p.D1951G	ODZ4_uc001ozk.3_Missense_Mutation_p.D176G|ODZ4_uc009yvb.1_Missense_Mutation_p.D535G	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1951	YD 7.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						AGAGAGGCGGTCATTCTTGTC	0.547													0	0	0	0.001984	0	6	122										C	78381538	T	C	78381538	3	2	117	1	0	0	0	0	1	0	0	0	10837	1667	58	5	2469	5	ODZ4	11	78381538	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	1874438	78381538	56624978	327	35317										
FOLH1B	219595	broad.mit.edu	37	chr11	89424091	89424091	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tatccactgtatcacagtgtCtatgaaacatatgagttggt	8	7	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:89424091C>A	uc001pda.2	+	11	1267	c.741C>A	c.(739-741)GTC>GTA	p.V247V		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	247					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ATCACAGTGTCTATGAAACAT	0.373													1	0	0.00307968	0.00308	0.00312232	5	44										A	89424091	C	A	89424091	2	1	117	1	0	0	0	0	0	0	0	1	5980	900	32	3		3	FOLH1B	11	89424091	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	11042553	89424091	45582425	328	35318										
USP28	57646	broad.mit.edu	37	chr11	113694393	113694393	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaatacactctctcttatttCgaataagctccttgctcctg	5	12	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:113694393C>T	uc001poh.2	-	12	1250	c.1217G>A	c.(1216-1218)CGA>CAA	p.R406Q	USP28_uc001pog.2_Missense_Mutation_p.R114Q|USP28_uc010rwy.1_Missense_Mutation_p.R281Q|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Missense_Mutation_p.R406Q	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	406					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCTCTTATTTCGAATAAGCTC	0.284													0	0	0	0.00245	0	11	4										T	113694393	C	T	113694393	3	4	117	1	0	0	0	0	1	0	0	0	17055	884	31	1	2072	1	USP28	11	113694393	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	24270302	113694393	21312123	329	35319										
SIAE	54414	broad.mit.edu	37	chr11	124518069	124518069	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttacagaatcgtatggaatgGacctgaaatcatatgatgca	9	6	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:124518069G>A	uc001qan.2	-	6	838	c.725C>T	c.(724-726)TCC>TTC	p.S242F		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	242						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		GTATGGAATGGACCTGAAATC	0.443													0	0	0	0.003954	0	23	25										A	124518069	G	A	124518069	3	1	117	1	0	0	0	0	1	0	0	0	14298	1174	41	1	866	1	SIAE	11	124518069	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	10823676	124518069	10488447	330	35320										
ARHGAP32	9743	broad.mit.edu	37	chr11	128936700	128936700	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcttcggtcataaatacacaGatgaagatgtttatcaagta	7	6	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:128936700G>C	uc009zcp.2	-	6	553	c.553C>G	c.(553-555)CTG>GTG	p.L185V	ARHGAP32_uc009zcq.1_Missense_Mutation_p.L145V|ARHGAP32_uc001qfb.2_Translation_Start_Site	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	185	PX; atypical.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TAAATACACAGATGAAGATGT	0.373													0	0	0	0.000602	0	5	28										C	128936700	G	C	128936700	3	2	117	1	0	0	0	0	1	0	0	0	881	933	33	1	5778	1	ARHGAP32	11	128936700	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4418631	128936700	6069816	331	35321										
ADAMTS8	11095	broad.mit.edu	37	chr11	130275534	130275534	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caggtggcagaggcctggccGgaggggtccctgcactctac	16	13	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:130275534G>A	uc001qgg.3	-	9	2947	c.2589C>T	c.(2587-2589)TCC>TCT	p.S863S	ADAMTS8_uc001qgf.2_Silent_p.S344S	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	863	TSP type-1 2.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		AGGCCTGGCCGGAGGGGTCCC	0.672													0	0	0	0.009096	0	3	68										A	130275534	G	A	130275534	2	1	117	1	0	0	0	0	0	0	0	1	272	1103	39	2		2	ADAMTS8	11	130275534	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1338834	130275534	4730982	332	35322										
SNX19	399979	broad.mit.edu	37	chr11	130785702	130785702	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cagcagccacacgttgaccaGaaggtgtatgaccaggagcc	12	12	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:130785702G>C	uc001qgk.3	-	1	681	c.133C>G	c.(133-135)CTG>GTG	p.L45V	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.L45V|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	45					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ACGTTGACCAGAAGGTGTATG	0.587													0	0	0	0.002299	0	20	71										C	130785702	G	C	130785702	3	2	117	1	0	0	0	0	1	0	0	0	14890	933	33	1	2889	1	SNX19	11	130785702	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	510168	130785702	4220814	333	35323										
VPS26B	112936	broad.mit.edu	37	chr11	134113161	134113161	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgacacgatagccaagtacGagatcatggacggggcacca	12	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr11:134113161G>C	uc001qhe.2	+	4	1150	c.694G>C	c.(694-696)GAG>CAG	p.E232Q		NM_052875	NP_443107	Q4G0F5	VP26B_HUMAN	vacuolar protein sorting 26 homolog B	232					protein transport|vacuolar transport	cytosol|retromer complex					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;2.43e-10)|all cancers(11;2.94e-09)|BRCA - Breast invasive adenocarcinoma(10;9.57e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00164)|Lung(977;0.216)		AGCCAAGTACGAGATCATGGA	0.537													0	0	0	0.006214	0	9	22										C	134113161	G	C	134113161	3	2	117	1	0	0	0	0	1	0	0	0	17195	1059	37	1	708	1	VPS26B	11	134113161	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3327459	134113161	893355	334	35324										
ENO2	2026	broad.mit.edu	37	chr12	7031509	7031509	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcctttgaaatgtttcagatCaagactggtgccccgtgccg	10	11	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:7031509C>G	uc001qru.1	+	11	1401	c.1179C>G	c.(1177-1179)ATC>ATG	p.I393M	ENO2_uc009zfi.1_Missense_Mutation_p.I393M|ENO2_uc010sfq.1_Missense_Mutation_p.I350M|ENO2_uc001qrv.1_Missense_Mutation_p.I393M|ATN1_uc001qrw.1_5'Flank	NM_001975	NP_001966	P09104	ENOG_HUMAN	enolase 2	393					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity				0						TGTTTCAGATCAAGACTGGTG	0.547													0	0	0	0.013114	0	38	62										G	7031509	C	G	7031509	3	3	117	1	0	0	0	0	1	0	0	0	5122	816	29	1	1217	1	ENO2	12	7031509	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		7031509	126820386	335	35325										
DDX47	51202	broad.mit.edu	37	chr12	12978977	12978977	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacagctagagctgggcgctCcggaaaggctattacttttg	12	9	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:12978977C>G	uc001rav.2	+	13	1677	c.1079C>G	c.(1078-1080)TCC>TGC	p.S360C	DDX47_uc001rax.2_Missense_Mutation_p.S360C|DDX47_uc001ray.2_Missense_Mutation_p.S311C	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	360	Helicase C-terminal.					nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		GCTGGGCGCTCCGGAAAGGCT	0.254													0	0	0	0.000602	0	5	47										G	12978977	C	G	12978977	3	3	117	1	0	0	0	0	1	0	0	0	4365	855	30	1	1117	1	DDX47	12	12978977	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5947468	12978977	120872918	336	35326										
DDX47	51202	broad.mit.edu	37	chr12	12980212	12980212	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	actcttccagcgcatagaacActtaattgggaagaaactac	7	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:12980212A>T	uc001rav.2	+	14	1737	c.1139A>T	c.(1138-1140)CAC>CTC	p.H380L	DDX47_uc001rax.2_Missense_Mutation_p.H380L|DDX47_uc001ray.2_Missense_Mutation_p.H331L	NM_016355	NP_057439	Q9H0S4	DDX47_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47	380	Helicase C-terminal.					nucleolus|nucleolus	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding				0		Prostate(47;0.0526)		BRCA - Breast invasive adenocarcinoma(232;0.0354)		CGCATAGAACACTTAATTGGG	0.473													0	0	0	0.003755	0	35	111										T	12980212	A	T	12980212	3	4	117	1	0	0	0	0	1	0	0	0	4365	159	6	5	1181	5	DDX47	12	12980212	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	1235	12980212	120871683	337	35327										
GSG1	83445	broad.mit.edu	37	chr12	13243611	13243611	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttggctgccagacctttctCgcacaggggcttgggcacct	12	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:13243611C>T	uc001rbn.2	-	2	363	c.190G>A	c.(190-192)GAG>AAG	p.E64K	GSG1_uc001rbj.2_Missense_Mutation_p.E51K|GSG1_uc001rbk.2_Missense_Mutation_p.E51K|GSG1_uc001rbl.2_Missense_Mutation_p.E51K|GSG1_uc001rbm.2_Missense_Mutation_p.E51K|GSG1_uc001rbo.2_Missense_Mutation_p.E64K|GSG1_uc001rbp.2_Missense_Mutation_p.E64K|GSG1_uc001rbq.1_Missense_Mutation_p.E64K	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	51						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		AGACCTTTCTCGCACAGGGGC	0.542													0	0	0	0.00361	0	56	95										T	13243611	C	T	13243611	3	4	117	1	0	0	0	0	1	0	0	0	6820	893	31	1	1046	1	GSG1	12	13243611	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	263399	13243611	120608284	338	35328										
PDE3A	5139	broad.mit.edu	37	chr12	20803462	20803462	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtataaagttggctgatatCaatggtccagctaaatgtaa	9	5	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:20803462C>G	uc001reh.1	+	14	2875	c.2853C>G	c.(2851-2853)ATC>ATG	p.I951M		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	951	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGGCTGATATCAATGGTCCAG	0.348													0	0	0	0.003271	0	32	31										G	20803462	C	G	20803462	3	3	117	1	0	0	0	0	1	0	0	0	11637	816	29	1	2907	1	PDE3A	12	20803462	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7559851	20803462	113048433	339	35329										
ST8SIA1	6489	broad.mit.edu	37	chr12	22408294	22408294	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccatttcccaccaccgcgcaTttcttcaatggcagctggaa	7	15	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:22408294T>A	uc001rfo.3	-	3	893	c.411A>T	c.(409-411)AAA>AAT	p.K137N	ST8SIA1_uc009zix.2_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	137	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CCACCGCGCATTTCTTCAATG	0.478													0	0	0	0.00361	0	108	107										A	22408294	T	A	22408294	3	1	117	1	0	0	0	0	1	0	0	0	15230	1490	52	5	671	5	ST8SIA1	12	22408294	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	1604832	22408294	111443601	340	35330										
BCAT1	586	broad.mit.edu	37	chr12	25031487	25031487	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agttccaatgaatgtaggacGaatatacagactagcagatg	10	6	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:25031487G>A	uc001rgd.3	-	5	929	c.487C>T	c.(487-489)CGT>TGT	p.R163C	BCAT1_uc001rgc.2_Missense_Mutation_p.R162C|BCAT1_uc010six.1_Missense_Mutation_p.R175C|BCAT1_uc010siy.1_Missense_Mutation_p.R126C|BCAT1_uc001rge.3_Missense_Mutation_p.R102C	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	163					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	AATGTAGGACGAATATACAGA	0.373													0	0	0	0.008361	0	23	26										A	25031487	G	A	25031487	3	1	117	1	0	0	0	0	1	0	0	0	1354	1058	37	1	701	1	BCAT1	12	25031487	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2623193	25031487	108820408	341	35331										
MLL2	8085	broad.mit.edu	37	chr12	49447270	49447270	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cattcctacctgcaggcttgGcacactttgcattcagggca	9	13	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:49447270G>A	uc001rta.3	-	6	828	c.828C>T	c.(826-828)TGC>TGT	p.C276C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	276	PHD-type 2.|PHD-type 1.|RING-type 2; degenerate.|Cys-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGCAGGCTTGGCACACTTTGC	0.557			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.00308	0	6	16										A	49447270	G	A	49447270	2	1	117	1	0	0	0	0	0	0	0	1	9621	1195	42	2		2	MLL2	12	49447270	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	24415783	49447270	84404625	342	35332										
BCDIN3D	144233	broad.mit.edu	37	chr12	50232675	50232675	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggaaaaggacattctttttCggctcgcttcaccaggactg	10	10	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:50232675C>T	uc001rvh.2	-	2	400	c.358G>A	c.(358-360)GAA>AAA	p.E120K	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	120	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						CATTCTTTTTCGGCTCGCTTC	0.488											OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	17	50										T	50232675	C	T	50232675	3	4	117	1	0	0	0	0	1	0	0	0	1357	893	31	1	524	1	BCDIN3D	12	50232675	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	785405	50232675	83619220	343	35333										
DIP2B	57609	broad.mit.edu	37	chr12	51117053	51117053	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tacctgtgaccgtcagacctCcacatgctcagaacctcacg	7	16	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51117053C>G	uc001rwv.2	+	27	3391	c.3235C>G	c.(3235-3237)CCA>GCA	p.P1079A	DIP2B_uc009zlt.2_Missense_Mutation_p.P509A	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1079						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						CGTCAGACCTCCACATGCTCA	0.522													0	0	0	0.013114	0	36	98										G	51117053	C	G	51117053	3	3	117	1	0	0	0	0	1	0	0	0	4528	855	30	1	3341	1	DIP2B	12	51117053	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	884378	51117053	82734842	344	35334										
DIP2B	57609	broad.mit.edu	37	chr12	51118560	51118560	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtccatttgttttctaggtCagcaaagcagcctgtattct	8	9	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51118560C>T	uc001rwv.2	+	28	3447	c.3291C>T	c.(3289-3291)GTC>GTT	p.V1097V	DIP2B_uc009zlt.2_Silent_p.V527V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1097						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TTTTCTAGGTCAGCAAAGCAG	0.532													0	0	0	0.00245	0	8	53										T	51118560	C	T	51118560	2	4	117	1	0	0	0	0	0	0	0	1	4528	813	29	1		1	DIP2B	12	51118560	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1507	51118560	82733335	345	35335										
DIP2B	57609	broad.mit.edu	37	chr12	51121551	51121551	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctcctgagatgttggcatatCttgattttagtgtctccaca	8	9	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51121551C>G	uc001rwv.2	+	29	3622	c.3466C>G	c.(3466-3468)CTT>GTT	p.L1156V	DIP2B_uc009zlt.2_Missense_Mutation_p.L586V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1156						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GTTGGCATATCTTGATTTTAG	0.433													0	0	0	0.00361	0	42	114										G	51121551	C	G	51121551	3	3	117	1	0	0	0	0	1	0	0	0	4528	913	32	1	3580	1	DIP2B	12	51121551	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2991	51121551	82730344	346	35336										
METTL7A	25840	broad.mit.edu	37	chr12	51319290	51319290	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgaagaaccaggagcggattCtccgcgaggtgtgcagagtg	16	8	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51319290C>T	uc001rxb.2	+	1	757	c.469C>T	c.(469-471)CTC>TTC	p.L157F	METTL7A_uc010smv.1_Intron	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	157						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						GGAGCGGATTCTCCGCGAGGT	0.562													0	0	0	0.007413	0	18	36										T	51319290	C	T	51319290	3	4	117	1	0	0	0	0	1	0	0	0	9505	913	32	1	471	1	METTL7A	12	51319290	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	197739	51319290	82532605	347	35337										
POU6F1	5463	broad.mit.edu	37	chr12	51585471	51585471	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggcccagcgagagccgccgGatcttaaagttcttggcaaa	12	11	2	1	rs150600315	byFrequency	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51585471G>A	uc001rxy.2	-	4	660	c.468C>T	c.(466-468)ATC>ATT	p.I156I	POU6F1_uc001rxz.2_Silent_p.I156I|POU6F1_uc001rya.2_Silent_p.I156I	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	156	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGAGCCGCCGGATCTTAAAGT	0.572													0	0	0	0.00361	0	43	93										A	51585471	G	A	51585471	2	1	117	1	0	0	0	0	0	0	0	1	12284	1164	41	1		1	POU6F1	12	51585471	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	266181	51585471	82266424	348	35338			2	166		4	4	737	G		3.755786e-07
POU6F1	5463	broad.mit.edu	37	chr12	51585498	51585498	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagttcttggcaaactcccgGatctcttctaagttgatccc	7	12	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51585498G>C	uc001rxy.2	-	4	633	c.441C>G	c.(439-441)ATC>ATG	p.I147M	POU6F1_uc001rxz.2_Missense_Mutation_p.I147M|POU6F1_uc001rya.2_Missense_Mutation_p.I147M	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	147	POU-specific.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAAACTCCCGGATCTCTTCTA	0.557													0	0	0	0.00361	0	52	118										C	51585498	G	C	51585498	3	2	117	1	0	0	0	0	1	0	0	0	12284	1164	41	1	472	1	POU6F1	12	51585498	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	27	51585498	82266397	349	35339			2	166		4	4	737	G		3.755786e-07
POU6F1	5463	broad.mit.edu	37	chr12	51586129	51586129	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttactggacaccaactggctGacggtgggggtctctgagca	14	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51586129G>A	uc001rxy.2	-	3	567	c.375C>T	c.(373-375)GTC>GTT	p.V125V	POU6F1_uc001rxz.2_Silent_p.V125V|POU6F1_uc001rya.2_Silent_p.V125V	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	125	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCAACTGGCTGACGGTGGGGG	0.582													0	0	0	0.00361	0	52	176										A	51586129	G	A	51586129	2	1	117	1	0	0	0	0	0	0	0	1	12284	1277	45	1		1	POU6F1	12	51586129	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	631	51586129	82265766	350	35340			2	166		4	4	737	G		3.755786e-07
POU6F1	5463	broad.mit.edu	37	chr12	51586207	51586207	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctggagctgggctggcaatGaccacagcaggctggggcac	17	11	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:51586207G>A	uc001rxy.2	-	3	489	c.297C>T	c.(295-297)GTC>GTT	p.V99V	POU6F1_uc001rxz.2_Silent_p.V99V|POU6F1_uc001rya.2_Silent_p.V99V	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	99	Gln/Pro-rich.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCTGGCAATGACCACAGCAG	0.607													0	0	0	0.00361	0	50	147										A	51586207	G	A	51586207	2	1	117	1	0	0	0	0	0	0	0	1	12284	1277	45	1		1	POU6F1	12	51586207	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	78	51586207	82265688	351	35341			2	166		4	4	737	G		3.755786e-07
KRT18	3875	broad.mit.edu	37	chr12	53345344	53345344	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccaaatctcaggacctcgCcaagatcatggcagacatcc	7	16	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:53345344C>A	uc001sbe.2	+	5	806	c.737C>A	c.(736-738)GCC>GAC	p.A246D	KRT18_uc009zmn.1_Missense_Mutation_p.A246D|KRT18_uc001sbf.1_Missense_Mutation_p.A73D|KRT18_uc001sbg.2_Missense_Mutation_p.A246D|KRT18_uc009zmo.2_Missense_Mutation_p.A246D|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	246	Interaction with DNAJB6.|Linker 12.|Rod.|Necessary for interaction with PNN.			A -> S (in Ref. 8; CAA31369).	anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						CAGGACCTCGCCAAGATCATG	0.562													1	0	7.93312e-07	0.00245	8.15589e-07	12	30										A	53345344	C	A	53345344	3	1	117	1	0	0	0	0	1	0	0	0	8455	739	26	4	751	4	KRT18	12	53345344	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1759137	53345344	80506551	352	35342										
RARG	5916	broad.mit.edu	37	chr12	53607440	53607440	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcagcccgtcggagaaggtCatggtgtcctgctctggggt	16	10	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:53607440C>G	uc001sce.2	-	8	1343	c.858G>C	c.(856-858)ATG>ATC	p.M286I	RARG_uc001scd.2_Missense_Mutation_p.M275I|RARG_uc010sob.1_Missense_Mutation_p.M264I|RARG_uc001scf.2_Missense_Mutation_p.M286I|RARG_uc001scg.2_Missense_Mutation_p.M214I|RARG_uc010soc.1_Missense_Mutation_p.M165I|RARG_uc010sod.1_Missense_Mutation_p.M323I	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	286	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CGGAGAAGGTCATGGTGTCCT	0.607											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	91	65										G	53607440	C	G	53607440	3	3	117	1	0	0	0	0	1	0	0	0	13054	826	29	1	518	1	RARG	12	53607440	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	262096	53607440	80244455	353	35343										
RARG	5916	broad.mit.edu	37	chr12	53607956	53607956	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttgatgatgcacttggtagCcagctcactgaacttgtccc	9	12	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:53607956C>G	uc001sce.2	-	7	1185	c.700G>C	c.(700-702)GCT>CCT	p.A234P	RARG_uc001scd.2_Missense_Mutation_p.A223P|RARG_uc010sob.1_Missense_Mutation_p.A212P|RARG_uc001scf.2_Missense_Mutation_p.A234P|RARG_uc001scg.2_Missense_Mutation_p.A162P|RARG_uc010soc.1_Missense_Mutation_p.A113P|RARG_uc010sod.1_Missense_Mutation_p.A271P	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	234	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CACTTGGTAGCCAGCTCACTG	0.567													0	0	0	0.010771	0	41	113										G	53607956	C	G	53607956	3	3	117	1	0	0	0	0	1	0	0	0	13054	739	26	4	680	4	RARG	12	53607956	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	516	53607956	80243939	354	35344										
HOXC9	3225	broad.mit.edu	37	chr12	54394234	54394234	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcccccagccccacctcggcGccgacacgcgctacatgcgg	11	21	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:54394234G>A	uc001sep.2	+	2	360	c.262G>A	c.(262-264)GCC>ACC	p.A88T	HOXC9_uc001seq.2_Missense_Mutation_p.A88T	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	88					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						CCACCTCGGCGCCGACACGCG	0.711													0	0	0	0.007835	0	33	19										A	54394234	G	A	54394234	3	1	117	1	0	0	0	0	1	0	0	0	7317	1087	38	2	264	2	HOXC9	12	54394234	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	786278	54394234	79457661	355	35345										
NFE2	4778	broad.mit.edu	37	chr12	54686942	54686942	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcggctcactgagcaggcctGagaggctcagtggcttggag	17	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:54686942G>C	uc009znk.2	-	2	848	c.338C>G	c.(337-339)TCA>TGA	p.S113*	NFE2_uc001sfq.2_Nonsense_Mutation_p.S113*|NFE2_uc001sfr.3_Nonsense_Mutation_p.S113*|NFE2_uc009znl.2_Nonsense_Mutation_p.S113*	NM_006163	NP_006154	Q16621	NFE2_HUMAN	nuclear factor, erythroid derived 2 isoform 1	113	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding				0						GAGCAGGCCTGAGAGGCTCAG	0.592													0	0	0	0.00361	0	44	108										C	54686942	G	C	54686942	4	2	117	1	0	0	0	0	0	1	0	0	10366	1294	45	1	787	1	NFE2	12	54686942	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	292708	54686942	79164953	356	35346										
SMARCC2	6601	broad.mit.edu	37	chr12	56572315	56572315	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccgtactgttctcatcctCatcctacgagtatggaggct	8	14	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:56572315C>G	uc001skb.2	-	14	1289	c.1183G>C	c.(1183-1185)GAG>CAG	p.E395Q	SMARCC2_uc001skd.2_Missense_Mutation_p.E395Q|SMARCC2_uc001ska.2_Missense_Mutation_p.E395Q|SMARCC2_uc001skc.2_Missense_Mutation_p.E395Q|SMARCC2_uc010sqf.1_Missense_Mutation_p.E284Q	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	395					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TTCTCATCCTCATCCTACGAG	0.527													0	0	0	0.00361	0	77	45										G	56572315	C	G	56572315	3	3	117	1	0	0	0	0	1	0	0	0	14776	835	29	1	2618	1	SMARCC2	12	56572315	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1885373	56572315	77279580	357	35347										
CAND1	55832	broad.mit.edu	37	chr12	67700122	67700122	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgggcaaccttcctgaatatCtgccgtttgtcctgcaagaa	9	11	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:67700122C>G	uc001stn.2	+	10	3111	c.2674C>G	c.(2674-2676)CTG>GTG	p.L892V	CAND1_uc001sto.2_Missense_Mutation_p.L402V	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	892	HEAT 21.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCCTGAATATCTGCCGTTTGT	0.418													0	0	0	0.007413	0	15	113										G	67700122	C	G	67700122	3	3	117	1	0	0	0	0	1	0	0	0	2615	912	32	1	2712	1	CAND1	12	67700122	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	11127807	67700122	66151773	358	35348										
STAB2	55576	broad.mit.edu	37	chr12	104123937	104123937	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggctaagatcatatccagtgAtatcatcagtactaatggga	9	7	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:104123937A>C	uc001tjw.2	+	49	5312	c.5126A>C	c.(5125-5127)GAT>GCT	p.D1709A	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1709	Extracellular (Potential).|FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ATATCCAGTGATATCATCAGT	0.333													0	0	0	0.012213	0	27	42										C	104123937	A	C	104123937	3	2	117	1	0	0	0	0	1	0	0	0	15237	333	12	5	5320	5	STAB2	12	104123937	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	36423815	104123937	29727958	359	35349										
COX6A1	1337	broad.mit.edu	37	chr12	120875952	120875952	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcggtagttggtgtgtcctCggtttctcggctgctgggtc	17	9	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:120875952C>T	uc001tyf.1	+	1	49	c.23C>T	c.(22-24)TCG>TTG	p.S8L		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	8					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTGTCCTCGGTTTCTCGG	0.637													0	0	0	0.003954	0	21	6										T	120875952	C	T	120875952	3	4	117	1	0	0	0	0	1	0	0	0	3774	893	31	1	25	1	COX6A1	12	120875952	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	16752015	120875952	12975943	360	35350										
HIP1R	9026	broad.mit.edu	37	chr12	123338615	123338615	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cgacagctcaacacggccatCgccgtatcccagatgtcctc	8	17	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:123338615C>T	uc001udj.1	+	8	662	c.603C>T	c.(601-603)ATC>ATT	p.I201I	HIP1R_uc001udg.1_Silent_p.I189I|HIP1R_uc001udi.1_Silent_p.I201I	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	201					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		ACACGGCCATCGCCGTATCCC	0.602													0	0	0	0.00361	0	88	246										T	123338615	C	T	123338615	2	4	117	1	0	0	0	0	0	0	0	1	7115	874	31	1		1	HIP1R	12	123338615	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2462663	123338615	10513280	361	35351										
EP400	57634	broad.mit.edu	37	chr12	132547196	132547196	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcaagttccacagatccagGgccaggcccagtccccagca	10	16	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr12:132547196G>A	uc001ujn.2	+	46	8319	c.8284G>A	c.(8284-8286)GGC>AGC	p.G2762S	EP400_uc001ujl.2_Missense_Mutation_p.G2761S|EP400_uc001ujm.2_Missense_Mutation_p.G2681S|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2798					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACAGATCCAGGGCCAGGCCCA	0.418													0	0	0	0.00361	0	51	48										A	132547196	G	A	132547196	3	1	117	1	0	0	0	0	1	0	0	0	5149	1232	43	2	8463	2	EP400	12	132547196	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	9208581	132547196	1304699	362	35352										
ZDHHC20	253832	broad.mit.edu	37	chr13	21955650	21955650	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acaagcggttttttgattcaCtaagtggtttgataggaaaa	10	4	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:21955650C>T	uc001uob.2	-	11	1093	c.980G>A	c.(979-981)AGT>AAT	p.S327N	ZDHHC20_uc001uod.2_RNA|ZDHHC20_uc001uoc.2_RNA|ZDHHC20_uc001uoe.2_RNA|ZDHHC20_uc010tcs.1_Missense_Mutation_p.S265N	NM_153251	NP_694983	Q5W0Z9	ZDH20_HUMAN	zinc finger, DHHC-type containing 20	328						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		all_cancers(29;8.1e-16)|all_epithelial(30;3.63e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000268)|Epithelial(112;0.000735)|OV - Ovarian serous cystadenocarcinoma(117;0.00517)|Lung(94;0.171)		TTTTGATTCACTAAGTGGTTT	0.378													0	0	0	0.009718	0	35	14										T	21955650	C	T	21955650	3	4	117	1	0	0	0	0	1	0	0	0	17608	565	20	2	92	2	ZDHHC20	13	21955650	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		21955650	93214228	363	35353										
ATP12A	479	broad.mit.edu	37	chr13	25274960	25274960	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catagacgctatgaactttcCgacctccaacctctgttttg	6	13	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:25274960C>T	uc001upp.2	+	13	1968	c.1781C>T	c.(1780-1782)CCG>CTG	p.P594L	ATP12A_uc010aaa.2_Missense_Mutation_p.P600L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	594	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATGAACTTTCCGACCTCCAAC	0.488													0	0	0	0.00361	0	61	28										T	25274960	C	T	25274960	3	4	117	1	0	0	0	0	1	0	0	0	1122	652	23	2	1849	2	ATP12A	13	25274960	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3319310	25274960	89894918	364	35354										
PABPC3	5042	broad.mit.edu	37	chr13	25671754	25671754	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggttccacgagtcatgtcaaCgcagcgtgttgctaacacat	10	11	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:25671754C>T	uc001upy.2	+	1	1479	c.1418C>T	c.(1417-1419)ACG>ATG	p.T473M		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	473					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GTCATGTCAACGCAGCGTGTT	0.423													0	0	0	0.00278	0	20	88										T	25671754	C	T	25671754	3	4	117	1	0	0	0	0	1	0	0	0	11365	536	19	2	1420	2	PABPC3	13	25671754	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	396794	25671754	89498124	365	35355										
RNF6	6049	broad.mit.edu	37	chr13	26788716	26788716	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaagcccccactattgctttCaatagtgactgtattttctg	6	10	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:26788716C>T	uc001uqo.2	-	5	1594	c.1303G>A	c.(1303-1305)GAA>AAA	p.E435K	RNF6_uc001uqn.1_Intron|RNF6_uc010aak.2_Missense_Mutation_p.E435K|RNF6_uc001uqp.2_Missense_Mutation_p.E435K|RNF6_uc001uqq.2_Missense_Mutation_p.E435K|RNF6_uc010tdk.1_Missense_Mutation_p.E79K	NM_183044	NP_898865	Q9Y252	RNF6_HUMAN	ring finger protein 6	435					negative regulation of axon extension|positive regulation of transcription, DNA-dependent|protein K27-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|regulation of androgen receptor signaling pathway|ubiquitin-dependent protein catabolic process	axon|cytoplasm|PML body	androgen receptor binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.00893)|Epithelial(112;0.0481)|OV - Ovarian serous cystadenocarcinoma(117;0.148)|GBM - Glioblastoma multiforme(144;0.23)|Lung(94;0.245)		CTATTGCTTTCAATAGTGACT	0.438													0	0	0	0.00361	0	39	126										T	26788716	C	T	26788716	3	4	117	1	0	0	0	0	1	0	0	0	13498	835	29	1	758	1	RNF6	13	26788716	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1116962	26788716	88381162	366	35356										
BRCA2	675	broad.mit.edu	37	chr13	32911868	32911868	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagaatcaggaagtcagtttGaatttactcagtttagaaaa	8	4	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32911868G>C	uc001uub.1	+	11	3603	c.3376G>C	c.(3376-3378)GAA>CAA	p.E1126Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1126					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGTCAGTTTGAATTTACTCA	0.343			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.003163	0	15	28										C	32911868	G	C	32911868	3	2	117	1	0	0	0	0	1	0	0	0	1499	1291	45	1	3414	1	BRCA2	13	32911868	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6123152	32911868	82258010	367	35357			3	167		5	5	2356	G		1.26781e-07
BRCA2	675	broad.mit.edu	37	chr13	32912648	32912648	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agattaaagaagatttgtcaGatttaacttttttggaagtt	8	2	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32912648G>T	uc001uub.1	+	11	4383	c.4156G>T	c.(4156-4158)GAT>TAT	p.D1386Y		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1386					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGATTTGTCAGATTTAACTTT	0.338			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			1	0	0.00136819	0.001368	0.00139357	10	36										T	32912648	G	T	32912648	3	4	117	1	0	0	0	0	1	0	0	0	1499	942	33	3	4194	3	BRCA2	13	32912648	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	780	32912648	82257230	368	35358			3	167		5	5	2356	G		1.26781e-07
BRCA2	675	broad.mit.edu	37	chr13	32913201	32913201	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcaaagaccctaaagtacaGagaggcctgtaaagaccttg	11	9	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32913201G>C	uc001uub.1	+	11	4936	c.4709G>C	c.(4708-4710)AGA>ACA	p.R1570T		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1570					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTAAAGTACAGAGAGGCCTGT	0.383			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008871	0	16	86										C	32913201	G	C	32913201	3	2	117	1	0	0	0	0	1	0	0	0	1499	942	33	1	4747	1	BRCA2	13	32913201	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	553	32913201	82256677	369	35359			3	167		5	5	2356	G		1.26781e-07
BRCA2	675	broad.mit.edu	37	chr13	32914175	32914175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaattatggcaggttgttacGaggcattggatgattcagag	13	4	1	2	rs146351301	by1000genomes	TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32914175G>A	uc001uub.1	+	11	5910	c.5683G>A	c.(5683-5685)GAG>AAG	p.E1895K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1895					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGGTTGTTACGAGGCATTGGA	0.338			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.008291	0	10	48										A	32914175	G	A	32914175	3	1	117	1	0	0	0	0	1	0	0	0	1499	1059	37	1	5721	1	BRCA2	13	32914175	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	974	32914175	82255703	370	35360			3	167		5	5	2356	G		1.26781e-07
BRCA2	675	broad.mit.edu	37	chr13	32914223	32914223	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttcataactctctagataatGatgaatgtagcacgcattca	6	8	3	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:32914223G>A	uc001uub.1	+	11	5958	c.5731G>A	c.(5731-5733)GAT>AAT	p.D1911N		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1911					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TCTAGATAATGATGAATGTAG	0.338			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.001368	0	11	38										A	32914223	G	A	32914223	3	1	117	1	0	0	0	0	1	0	0	0	1499	1290	45	1	5769	1	BRCA2	13	32914223	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	48	32914223	82255655	371	35361			3	167		5	5	2356	G		1.26781e-07
SCEL	8796	broad.mit.edu	37	chr13	78163292	78163292	+	Missense_Mutation	SNP	C	C	T													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tttaaagggaaccaggtgttCaccctccaatacctccaaag							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:78163292C>T	uc001vki.2	+	10	729	c.559C>T	c.(559-561)CAC>TAC	p.H187Y	SCEL_uc001vkj.2_Missense_Mutation_p.H187Y|SCEL_uc010thx.1_Missense_Mutation_p.H165Y	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	187					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ACCAGGTGTTCACCCTCCAAT	0.393													0	0	0	0.006122	0	14	70										T	78163292	C	T	78163292	3	4	117	1	0	0	0	0	1	0	0	0	13888	826	29	1	593	1	SCEL	13	78163292	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	45249069	78163292	37006586	372	35362	184	2								
SCEL	8796	broad.mit.edu	37	chr13	78163298	78163298	+	Missense_Mutation	SNP	C	C	T													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gggaaccaggtgttcaccctCcaatacctccaaagcccagt							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:78163298C>T	uc001vki.2	+	10	735	c.565C>T	c.(565-567)CCA>TCA	p.P189S	SCEL_uc001vkj.2_Missense_Mutation_p.P189S|SCEL_uc010thx.1_Missense_Mutation_p.P167S	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	189					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		TGTTCACCCTCCAATACCTCC	0.393													0	0	0	0.008871	0	15	75										T	78163298	C	T	78163298	3	4	117	1	0	0	0	0	1	0	0	0	13888	855	30	1	599	1	SCEL	13	78163298	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6	78163298	37006580	373	35363	184	2								
DZIP1	22873	broad.mit.edu	37	chr13	96238358	96238358	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcgatgtggaaacatcttttCaactttttcagtaggtgttt	9	6	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:96238358C>T	uc001vmk.2	-	21	3103	c.2251G>A	c.(2251-2253)GAA>AAA	p.E751K	DZIP1_uc001vmi.2_5'UTR|DZIP1_uc001vmj.2_Missense_Mutation_p.E227K|DZIP1_uc001vml.2_Missense_Mutation_p.E732K|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	751					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AACATCTTTTCAACTTTTTCA	0.308													0	0	0	0.008291	0	10	26										T	96238358	C	T	96238358	3	4	117	1	0	0	0	0	1	0	0	0	4863	835	29	1	364	1	DZIP1	13	96238358	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	18075060	96238358	18931520	374	35364										
NALCN	259232	broad.mit.edu	37	chr13	101735186	101735186	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacaaagatgaaggtgaaaaCaactgacattgttgccaaag	9	6	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:101735186C>G	uc001vox.1	-	33	3928	c.3739G>C	c.(3739-3741)GTT>CTT	p.V1247L		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1247	Helical; Name=S2 of repeat IV; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAGGTGAAAACAACTGACATT	0.493													0	0	0	0.00632	0	26	106										G	101735186	C	G	101735186	3	3	117	1	0	0	0	0	1	0	0	0	10148	478	17	4	1525	4	NALCN	13	101735186	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5496828	101735186	13434692	375	35365										
TPP2	7174	broad.mit.edu	37	chr13	103275268	103275268	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agatggggacttgagtaaatCtaccgtgttgagaaactaca	11	6	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:103275268C>T	uc001vpi.3	+	6	765	c.662C>T	c.(661-663)TCT>TTT	p.S221F		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	221					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGAGTAAATCTACCGTGTTG	0.343													0	0	0	0.003954	0	23	109										T	103275268	C	T	103275268	3	4	117	1	0	0	0	0	1	0	0	0	16409	913	32	1	684	1	TPP2	13	103275268	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1540082	103275268	11894610	376	35366										
CARS2	79587	broad.mit.edu	37	chr13	111340160	111340160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cggttaccctcaggtacaccGtgggtgggagaacctgcaag	14	11	1	1	rs143602497		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:111340160G>A	uc001vrd.2	-	5	519	c.479C>T	c.(478-480)ACG>ATG	p.T160M	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	160					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	CAGGTACACCGTGGGTGGGAG	0.507													0	0	0	0.00361	0	47	131										A	111340160	G	A	111340160	3	1	117	1	0	0	0	0	1	0	0	0	2658	1145	40	2	1259	2	CARS2	13	111340160	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8064892	111340160	3829718	377	35367										
PROZ	8858	broad.mit.edu	37	chr13	113814360	113814360	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctccaaagcaaacgacgttCtggtgaggtggaagcgtgcg	14	10	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:113814360C>T	uc001vta.1	+	2	110	c.103C>T	c.(103-105)CTG>TTG	p.L35L	PROZ_uc010agr.1_Silent_p.L57L	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	35					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	AAACGACGTTCTGGTGAGGTG	0.517													0	0	0	0.00361	0	72	233										T	113814360	C	T	113814360	2	4	117	1	0	0	0	0	0	0	0	1	12562	912	32	1		1	PROZ	13	113814360	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2474200	113814360	1355518	378	35368										
FAM70B	348013	broad.mit.edu	37	chr13	114503880	114503880	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgctgtgacctctatgcctgCgggaggtgaggggcaccggg	18	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr13:114503880C>T	uc001vuh.2	+	6	531	c.504C>T	c.(502-504)TGC>TGT	p.C168C		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	168						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			TCTATGCCTGCGGGAGGTGAG	0.647													0	0	0	0.004289	0	20	12										T	114503880	C	T	114503880	2	4	117	1	0	0	0	0	0	0	0	1	5606	776	27	2		2	FAM70B	13	114503880	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	689520	114503880	665998	379	35369										
PSME1	5720	broad.mit.edu	37	chr14	24606976	24606976	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgcagcgcttgaagcctgaGatcaaggatgtcattgagca	12	9	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:24606976G>A	uc001wmg.2	+	6	454	c.360G>A	c.(358-360)GAG>GAA	p.E120E	PSME1_uc001wmh.2_Silent_p.E120E	NM_006263	NP_006254	Q06323	PSME1_HUMAN	proteasome activator subunit 1 isoform 1	120					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00831)		TGAAGCCTGAGATCAAGGATG	0.512													0	0	0	0.007835	0	29	48										A	24606976	G	A	24606976	2	1	117	1	0	0	0	0	0	0	0	1	12706	933	33	1		1	PSME1	14	24606976	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		24606976	82742564	380	35370										
TGM1	7051	broad.mit.edu	37	chr14	24727513	24727513	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgctagtctcttggggtgtGgcatccaccacctgccaccc	10	16	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:24727513G>A	uc001wod.2	-	9	1504	c.1380C>T	c.(1378-1380)GCC>GCT	p.A460A	TGM1_uc010tog.1_Silent_p.A18A	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	460					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CTTGGGGTGTGGCATCCACCA	0.592													0	0	0	0.003954	0	21	29										A	24727513	G	A	24727513	2	1	117	1	0	0	0	0	0	0	0	1	15826	1335	47	2		2	TGM1	14	24727513	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	120537	24727513	82622027	381	35371										
NUBPL	80224	broad.mit.edu	37	chr14	32068580	32068580	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaaaggaaatccggaattatCacagagtaagtaaagaaggg	12	4	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:32068580C>T	uc001wrk.3	+	4	432	c.377C>T	c.(376-378)TCA>TTA	p.S126L	NUBPL_uc010amj.2_RNA|NUBPL_uc010tpl.1_Missense_Mutation_p.S30L	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	126					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		CCGGAATTATCACAGAGTAAG	0.234													0	0	0	0.004007	0	17	26										T	32068580	C	T	32068580	3	4	117	1	0	0	0	0	1	0	0	0	10717	838	29	1	391	1	NUBPL	14	32068580	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7341067	32068580	75280960	382	35372										
ARHGAP5	394	broad.mit.edu	37	chr14	32560834	32560834	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaaggccagaaatacattctCaaaacatatagaacaactta	4	8	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:32560834C>G	uc001wrl.2	+	2	1198	c.959C>G	c.(958-960)TCA>TGA	p.S320*	ARHGAP5_uc001wrm.2_Nonsense_Mutation_p.S320*|ARHGAP5_uc001wrn.2_Nonsense_Mutation_p.S320*|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	320	FF 1.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AATACATTCTCAAAACATATA	0.299													0	0	0	0.007413	0	15	19										G	32560834	C	G	32560834	4	3	117	1	0	0	0	0	0	1	0	0	886	838	29	1	961	1	ARHGAP5	14	32560834	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	492254	32560834	74788706	383	35373										
CFL2	1073	broad.mit.edu	37	chr14	35182587	35182587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtaggggtcctctacagtatCaccaatgtcacccaccaaga	8	13	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:35182587C>G	uc001wsg.3	-	2	325	c.184G>C	c.(184-186)GAT>CAT	p.D62H	CFL2_uc010tpn.1_Missense_Mutation_p.D45H|CFL2_uc001wsh.3_Missense_Mutation_p.D62H|CFL2_uc001wsi.3_Intron|CFL2_uc001wsj.3_Intron	NM_021914	NP_068733	Q9Y281	COF2_HUMAN	cofilin 2	62	ADF-H.					cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(2)	2	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		TCTACAGTATCACCAATGTCA	0.398													0	0	0	0.003954	0	20	28										G	35182587	C	G	35182587	3	3	117	1	0	0	0	0	1	0	0	0	3291	826	29	1	328	1	CFL2	14	35182587	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2621753	35182587	72166953	384	35374										
C14orf106	55320	broad.mit.edu	37	chr14	45693269	45693269	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	accagacttctgaagagtttCtttgacggaaggtctagctt	10	8	3	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:45693269C>T	uc001wwf.2	-	11	2980	c.2521G>A	c.(2521-2523)GAA>AAA	p.E841K		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	841					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TGAAGAGTTTCTTTGACGGAA	0.358													0	0	0	0.001168	0	5	12										T	45693269	C	T	45693269	3	4	117	1	0	0	0	0	1	0	0	0	1738	922	32	1	905	1	C14orf106	14	45693269	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	10510682	45693269	61656271	385	35375										
L2HGDH	79944	broad.mit.edu	37	chr14	50735964	50735964	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaatggtacaattcgaggatCaggagtgcagccactcaact	11	9	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:50735964C>G	uc001wxu.2	-	7	902	c.823G>C	c.(823-825)GAT>CAT	p.D275H	L2HGDH_uc010tqn.1_Missense_Mutation_p.D275H|L2HGDH_uc010tqo.1_Missense_Mutation_p.D275H	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	275					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					ATTCGAGGATCAGGAGTGCAG	0.408													0	0	0	0.00361	0	52	72										G	50735964	C	G	50735964	3	3	117	1	0	0	0	0	1	0	0	0	8590	826	29	1	584	1	L2HGDH	14	50735964	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5042695	50735964	56613576	386	35376										
NID2	22795	broad.mit.edu	37	chr14	52477650	52477650	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	accagatctgtgtagaagagGaccttgcgctcagagccatc	11	11	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:52477650G>A	uc001wzo.2	-	18	3900	c.3666C>T	c.(3664-3666)GTC>GTT	p.V1222V	NID2_uc010tqs.1_Silent_p.V1174V|NID2_uc010tqt.1_Silent_p.V1222V	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1222	LDL-receptor class B 2.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TGTAGAAGAGGACCTTGCGCT	0.532													0	0	0	0.002836	0	32	53										A	52477650	G	A	52477650	2	1	117	1	0	0	0	0	0	0	0	1	10415	1161	41	1		1	NID2	14	52477650	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1741686	52477650	54871890	387	35377										
C14orf135	64430	broad.mit.edu	37	chr14	60585115	60585115	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tttgccgtgactgtgcttttGacatcatggacagagaaaaa	10	7	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:60585115G>C	uc001xer.3	+	6	1467	c.945G>C	c.(943-945)TTG>TTC	p.L315F	C14orf135_uc001xeq.2_Missense_Mutation_p.L315F|C14orf135_uc010apm.2_RNA	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	hepatitis C virus F protein-binding protein 2	549	Helical; (Potential).					integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		CTGTGCTTTTGACATCATGGA	0.338													0	0	0	0.000602	0	5	9										C	60585115	G	C	60585115	3	2	117	1	0	0	0	0	1	0	0	0	1745	1281	45	1	963	1	C14orf135	14	60585115	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8107465	60585115	46764425	388	35378										
SYNE2	23224	broad.mit.edu	37	chr14	64545285	64545285	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gttgaaaagatgttgcagcaGaaaagcaaaaatattgagaa	10	3	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:64545285G>C	uc001xgm.2	+	55	11354	c.11124G>C	c.(11122-11124)CAG>CAC	p.Q3708H	SYNE2_uc001xgl.2_Missense_Mutation_p.Q3708H|SYNE2_uc010apy.2_Missense_Mutation_p.Q70H|SYNE2_uc010apw.1_Missense_Mutation_p.Q414H|SYNE2_uc010apx.1_Missense_Mutation_p.Q100H	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3708	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGTTGCAGCAGAAAAGCAAAA	0.358													0	0	0	0.00308	0	8	12										C	64545285	G	C	64545285	3	2	117	1	0	0	0	0	1	0	0	0	15443	933	33	1	11338	1	SYNE2	14	64545285	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3960170	64545285	42804255	389	35379										
SYNE2	23224	broad.mit.edu	37	chr14	64680977	64680977	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaagaccccagagaaatccaGactgattcttggcgtaaacg	10	10	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:64680977G>C	uc001xgm.2	+	106	19352	c.19122G>C	c.(19120-19122)CAG>CAC	p.Q6374H	SYNE2_uc001xgl.2_Missense_Mutation_p.Q6374H|SYNE2_uc010apy.2_Missense_Mutation_p.Q2759H|SYNE2_uc001xgn.2_Missense_Mutation_p.Q1336H|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.Q344H|SYNE2_uc001xgq.2_Missense_Mutation_p.Q739H|SYNE2_uc001xgr.2_Missense_Mutation_p.Q157H|SYNE2_uc010tsi.1_Missense_Mutation_p.Q8H|SYNE2_uc001xgs.2_Missense_Mutation_p.Q8H|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6374	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAGAAATCCAGACTGATTCTT	0.512													0	0	0	0.00361	0	43	56										C	64680977	G	C	64680977	3	2	117	1	0	0	0	0	1	0	0	0	15443	933	33	1	19540	1	SYNE2	14	64680977	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	135692	64680977	42668563	390	35380										
C14orf4	64207	broad.mit.edu	37	chr14	77492329	77492329	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccggttggaatggggtcccaGaggtgggggcggcggaggcg	23	8	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:77492329G>A	uc001xsy.2	-	1	2706	c.1807C>T	c.(1807-1809)CTG>TTG	p.L603L		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	603	Pro-rich.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		TGGGGTCCCAGAGGTgggggc	0.507													0	0	0	0.009096	0	3	4										A	77492329	G	A	77492329	2	1	117	1	0	0	0	0	0	0	0	1	1773	933	33	1		1	C14orf4	14	77492329	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	12811352	77492329	29857211	391	35381										
KIAA1737	85457	broad.mit.edu	37	chr14	77580381	77580381	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccgcagcccagatatcttttCagagcagcggcagagcaaac	10	13	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:77580381C>T	uc001xtd.2	+	4	1099	c.920C>T	c.(919-921)TCA>TTA	p.S307L	KIAA1737_uc001xtc.1_Missense_Mutation_p.S209L	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	KIAA1737 protein	307											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		GATATCTTTTCAGAGCAGCGG	0.478													0	0	0	0.010504	0	19	36										T	77580381	C	T	77580381	3	4	117	1	0	0	0	0	1	0	0	0	8255	838	29	1	930	1	KIAA1737	14	77580381	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	88052	77580381	29769159	392	35382										
ADCK1	57143	broad.mit.edu	37	chr14	78397944	78397944	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgccgcgccagatgctgctCatcttgaagaccaacgacct	10	14	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:78397944C>G	uc001xui.2	+	10	1389	c.1290C>G	c.(1288-1290)CTC>CTG	p.L430L	ADCK1_uc001xuj.2_Silent_p.L362L|ADCK1_uc001xul.2_Silent_p.L137L	NM_020421	NP_065154	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1 isoform a	437	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		AGATGCTGCTCATCTTGAAGA	0.602													0	0	0	0.003954	0	25	43										G	78397944	C	G	78397944	2	3	117	1	0	0	0	0	0	0	0	1	288	813	29	1		1	ADCK1	14	78397944	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	817563	78397944	28951596	393	35383										
AKT1	207	broad.mit.edu	37	chr14	105242100	105242100	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcctcctgcttcttgaggccGtcagccacagtctggatggc	11	14	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:105242100G>A	uc001ypk.2	-	5	878	c.324C>T	c.(322-324)GAC>GAT	p.D108D	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.D108D|AKT1_uc010axa.2_Silent_p.D108D|AKT1_uc001ypm.2_Silent_p.D108D|AKT1_uc001ypn.2_Silent_p.D108D|AKT1_uc010tyk.1_Silent_p.D46D	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	108	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	TCTTGAGGCCGTCAGCCACAG	0.617		1	Mis		breast|colorectal|ovarian|NSCLC								0	0	0	0.007291	0	21	7										A	105242100	G	A	105242100	2	1	117	1	0	0	0	0	0	0	0	1	478	1136	40	2		2	AKT1	14	105242100	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	26844156	105242100	2107440	394	35384										
AHNAK2	113146	broad.mit.edu	37	chr14	105419487	105419487	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttgaggtccactttgggcatCttcaaactgggcctctgcac	10	12	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr14:105419487C>T	uc010axc.1	-	7	2421	c.2301G>A	c.(2299-2301)AAG>AAA	p.K767K	AHNAK2_uc001ypx.2_Silent_p.K667K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	767						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTTTGGGCATCTTCAAACTGG	0.617													0	0	0	0.00361	0	46	25										T	105419487	C	T	105419487	2	4	117	1	0	0	0	0	0	0	0	1	415	912	32	1		1	AHNAK2	14	105419487	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	177387	105419487	1930053	395	35385										
UBE3A	7337	broad.mit.edu	37	chr15	25615955	25615955	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agtataatctttatccatttCtagaacctcattcagtggtt	5	8	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:25615955C>G	uc001zaq.2	-	4	1375	c.1375G>C	c.(1375-1377)GAA>CAA	p.E459Q	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.E436Q|UBE3A_uc001zas.2_Missense_Mutation_p.E456Q|UBE3A_uc001zat.2_Missense_Mutation_p.E436Q	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	459	Interaction with HCV core protein.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TTATCCATTTCTAGAACCTCA	0.353													0	0	0	0.000602	0	5	17										G	25615955	C	G	25615955	3	3	117	1	0	0	0	0	1	0	0	0	16876	922	32	1	1284	1	UBE3A	15	25615955	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		25615955	76915437	396	35386										
KLF13	51621	broad.mit.edu	37	chr15	31619856	31619856	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gggagcggcgagcccggcctCagacaaagggtccggcgggg	20	12	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:31619856C>G	uc001zfo.2	+	1	774	c.441C>G	c.(439-441)CTC>CTG	p.L147L		NM_015995	NP_057079	Q9Y2Y9	KLF13_HUMAN	Kruppel-like factor 13	147					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding				0		all_lung(180;3.71e-11)		all cancers(64;1.11e-18)|Epithelial(43;1.73e-14)|GBM - Glioblastoma multiforme(186;0.00016)|Colorectal(1;0.00158)|BRCA - Breast invasive adenocarcinoma(123;0.00255)|COAD - Colon adenocarcinoma(236;0.0446)|READ - Rectum adenocarcinoma(1;0.13)|Lung(196;0.171)		AGCCCGGCCTCAGACAAAGGG	0.642													0	0	0	0.000602	0	4	6										G	31619856	C	G	31619856	2	3	117	1	0	0	0	0	0	0	0	1	8341	813	29	1		1	KLF13	15	31619856	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6003901	31619856	70911536	397	35387										
RYR3	6263	broad.mit.edu	37	chr15	34130198	34130198	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaatctttctgaacacatgcCaaacgattcccgcctgaagt	6	12	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:34130198C>A	uc001zhi.2	+	89	12087	c.12017C>A	c.(12016-12018)CCA>CAA	p.P4006Q	RYR3_uc010bar.2_Missense_Mutation_p.P4001Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4006					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAACACATGCCAAACGATTCC	0.463													1	0	2.46799e-47	0.00361	2.70616e-47	78	114										A	34130198	C	A	34130198	3	1	117	1	0	0	0	0	1	0	0	0	13770	594	21	4	12371	4	RYR3	15	34130198	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2510342	34130198	68401194	398	35388										
PAK6	56924	broad.mit.edu	37	chr15	40566413	40566424	+	In_Frame_Del	DEL	CCCCAGTGCAAG	CCCCAGTGCAAG	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccaccgtacttcagtgactCcccagtgcaagccatgaaga					rs74468066		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:40566413_40566424delCCCCAGTGCAAG	uc010bbl.2	+	10	2254_2265	c.1814_1825delCCCCAGTGCAAG	c.(1813-1827)TCCCCAGTGCAAGCC>TCC	p.PVQA606del	PAK6_uc010bbm.2_In_Frame_Del_p.PVQA606del|PAK6_uc001zky.3_Intron|PAK6_uc010bbn.2_In_Frame_Del_p.PVQA606del|PAK6_uc001zlb.2_In_Frame_Del_p.PVQA606del	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	606_609	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TTCAGTGACTCCCCAGTGCAAGCCATGAAGAG	0.571											OREG0023057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						40	87	---	---								-	40566424	CCCCAGTGCAAG	-	40566413	7	5	117	1	0	1	0	1	0	0	0	0	11404	855	30	0	1840	0	PAK6	15	40566413	In_Frame_Del	DEL	CCCCAGTGCAAG	TCGA-GV-A3JZ-01A-11D-A21A-08	6436215	40566413	61964979	399	35389										
INO80	54617	broad.mit.edu	37	chr15	41339643	41339643	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagcataaggtttgccatttCtgctggagatatatcaataa	8	6	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:41339643C>G	uc001zni.2	-	23	2911	c.2698G>C	c.(2698-2700)GAA>CAA	p.E900Q	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	900	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TTTGCCATTTCTGCTGGAGAT	0.373													0	0	0	0.003755	0	26	21										G	41339643	C	G	41339643	3	3	117	1	0	0	0	0	1	0	0	0	7746	922	32	1	2028	1	INO80	15	41339643	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	773230	41339643	61191749	400	35390										
RPAP1	26015	broad.mit.edu	37	chr15	41816160	41816160	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggtggccgagaggctggcctCagcagaatcactacaaaagt	13	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:41816160C>T	uc001zod.2	-	17	2369	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	RPAP1_uc001zoc.2_5'UTR	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	749						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AGGCTGGCCTCAGCAGAATCA	0.587													0	0	0	0.00308	0	8	14										T	41816160	C	T	41816160	3	4	117	1	0	0	0	0	1	0	0	0	13541	835	29	1	1972	1	RPAP1	15	41816160	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	476517	41816160	60715232	401	35391										
JMJD7-PLA2G4B	8681	broad.mit.edu	37	chr15	42132996	42132996	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcatggaactgaaagtctttGaccaggacctggtgaccgga	12	9	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:42132996G>C	uc010bco.2	+	4	345	c.244G>C	c.(244-246)GAC>CAC	p.D82H	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.D313H|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.D313H|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	82	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						GAAAGTCTTTGACCAGGACCT	0.597													0	0	0	0.005443	0	26	93										C	42132996	G	C	42132996	3	2	117	1	0	0	0	0	1	0	0	0	7955	1290	45	1	971	1	JMJD7-PLA2G4B	15	42132996	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	316836	42132996	60398396	402	35392										
USP8	9101	broad.mit.edu	37	chr15	50757369	50757369	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tacattctctcagtgttcctGaagaagccatcagtccaggg	9	11	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:50757369G>A	uc001zym.3	+	8	1167	c.667G>A	c.(667-669)GAA>AAA	p.E223K	USP8_uc001zyk.1_5'UTR|USP8_uc001zyl.3_Missense_Mutation_p.E223K|USP8_uc001zyn.3_Missense_Mutation_p.E223K|USP8_uc010ufh.1_Missense_Mutation_p.E146K|USP8_uc010bev.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	223	Rhodanese.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		CAGTGTTCCTGAAGAAGCCAT	0.378													0	0	0	0.00632	0	21	63										A	50757369	G	A	50757369	3	1	117	1	0	0	0	0	1	0	0	0	17086	1291	45	1	689	1	USP8	15	50757369	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8624373	50757369	51774023	403	35393										
LIPC	3990	broad.mit.edu	37	chr15	58838000	58838000	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccagcaatcgtctttctccaGatgatgccaattttgtggat	8	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:58838000G>C	uc010bga.1	+	7	1242	c.634G>C	c.(634-636)GAT>CAT	p.D212H	LIPC_uc010bfz.1_Missense_Mutation_p.D212H|LIPC_uc002afa.1_Missense_Mutation_p.D212H|LIPC_uc010bgb.1_Missense_Mutation_p.D110H|LIPC_uc010ugy.1_Missense_Mutation_p.D151H	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	212					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TCTTTCTCCAGATGATGCCAA	0.537													0	0	0	0.00361	0	189	128										C	58838000	G	C	58838000	3	2	117	1	0	0	0	0	1	0	0	0	8820	942	33	1	652	1	LIPC	15	58838000	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8080631	58838000	43693392	404	35394										
VPS13C	54832	broad.mit.edu	37	chr15	62212771	62212771	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtatttcctgaagaaatatGaattgccatttgtggctcag	9	6	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:62212771G>A	uc002agz.2	-	56	7212	c.7138C>T	c.(7138-7140)CAT>TAT	p.H2380Y	VPS13C_uc002aha.2_Missense_Mutation_p.H2337Y|VPS13C_uc002ahb.1_Missense_Mutation_p.H2380Y|VPS13C_uc002ahc.1_Missense_Mutation_p.H2337Y|VPS13C_uc002ahd.1_5'Flank	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2380					protein localization					ovary(2)	2						GAAGAAATATGAATTGCCATT	0.313													0	0	0	0.012319	0	14	9										A	62212771	G	A	62212771	3	1	117	1	0	0	0	0	1	0	0	0	17188	1290	45	1	4271	1	VPS13C	15	62212771	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3374771	62212771	40318621	405	35395										
VPS13C	54832	broad.mit.edu	37	chr15	62254674	62254674	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcagtatacaaatccccctCagtagcatctggatacaaat	6	11	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:62254674C>A	uc002agz.2	-	34	3573	c.3499G>T	c.(3499-3501)GAG>TAG	p.E1167*	VPS13C_uc002aha.2_Nonsense_Mutation_p.E1124*|VPS13C_uc002ahb.1_Nonsense_Mutation_p.E1167*|VPS13C_uc002ahc.1_Nonsense_Mutation_p.E1124*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1167					protein localization					ovary(2)	2						AAATCCCCCTCAGTAGCATCT	0.388													1	0	1.18608e-55	0.00361	1.30706e-55	121	92										A	62254674	C	A	62254674	4	1	117	1	0	0	0	0	0	1	0	0	17188	835	29	3	7998	3	VPS13C	15	62254674	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	41903	62254674	40276718	406	35396										
FBXL22	283807	broad.mit.edu	37	chr15	63893794	63893794	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaagcaggggcgcacgggcaGaaggagccaccgagccgctc	17	13	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:63893794G>A	uc002amn.2	+	2	649	c.635G>A	c.(634-636)AGA>AAA	p.R212K	uc002amj.2_5'Flank|uc002amk.2_5'Flank|uc002aml.2_5'Flank	NM_203373	NP_976307	Q6P050	FXL22_HUMAN	F-box and leucine-rich repeat protein 22	212											0						CGCACGGGCAGAAGGAGCCAC	0.716													0	0	0	0.006214	0	8	3										A	63893794	G	A	63893794	3	1	117	1	0	0	0	0	1	0	0	0	5719	942	33	1	641	1	FBXL22	15	63893794	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1639120	63893794	38637598	407	35397										
SMAD3	4088	broad.mit.edu	37	chr15	67477081	67477081	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtaggaagaggcgtgcggctCtactacatcggaggggaggt	18	7	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:67477081C>G	uc002aqj.2	+	7	1186	c.888C>G	c.(886-888)CTC>CTG	p.L296L	SMAD3_uc010ujr.1_Silent_p.L191L|SMAD3_uc010ujs.1_Silent_p.L252L|SMAD3_uc010ujt.1_Silent_p.L101L	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	296	Sufficient for interaction with XPO4.|MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GCGTGCGGCTCTACTACATCG	0.587													0	0	0	0.008361	0	24	87										G	67477081	C	G	67477081	2	3	117	1	0	0	0	0	0	0	0	1	14759	900	32	1		1	SMAD3	15	67477081	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3583287	67477081	35054311	408	35398										
C15orf59	388135	broad.mit.edu	37	chr15	74032703	74032703	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtggcccattggggatgggcGtgccaccattcatgaggcgg	17	10	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:74032703G>A	uc002avy.2	-	2	782	c.437C>T	c.(436-438)ACG>ATG	p.T146M		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	146										pancreas(1)	1						GGGGATGGGCGTGCCACCATT	0.667													0	0	0	0.004656	0	19	64										A	74032703	G	A	74032703	3	1	117	1	0	0	0	0	1	0	0	0	1807	1145	40	2	448	2	C15orf59	15	74032703	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6555622	74032703	28498689	409	35399										
CSK	1445	broad.mit.edu	37	chr15	75092810	75092810	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcattaaaccaaaggtcatgGagggcacagtggcggcccag	13	10	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:75092810G>C	uc010bkb.1	+	7	703	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	CSK_uc002ays.2_Missense_Mutation_p.E174Q|CSK_uc010bkc.1_5'UTR	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	174					blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						AAAGGTCATGGAGGGCACAGT	0.622											OREG0023291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	14	35										C	75092810	G	C	75092810	3	2	117	1	0	0	0	0	1	0	0	0	3943	1175	41	1	538	1	CSK	15	75092810	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1060107	75092810	27438582	410	35400										
IMP3	55272	broad.mit.edu	37	chr15	75932413	75932413	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cagccggtaacgccgcagcaCgcgcagctcgtgcaggttgt	14	14	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:75932413C>T	uc002bat.2	-	2	1041	c.97G>A	c.(97-99)GTG>ATG	p.V33M	IMP3_uc010bkl.1_Missense_Mutation_p.V33M	NM_018285	NP_060755	Q9NV31	IMP3_HUMAN	IMP3, U3 small nucleolar ribonucleoprotein	33	Arg-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	protein binding|rRNA binding				0						CGCCGCAGCACGCGCAGCTCG	0.657													0	0	0	0.010729	0	8	21										T	75932413	C	T	75932413	3	4	117	1	0	0	0	0	1	0	0	0	7719	536	19	2	461	2	IMP3	15	75932413	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	839603	75932413	26598979	411	35401										
MESDC2	23184	broad.mit.edu	37	chr15	81282044	81282044	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agccttcggccgcgcaggacCcaggcggtggtagcagtagc	16	13	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:81282044C>A	uc002bfy.1	-	1	162	c.89G>T	c.(88-90)GGG>GTG	p.G30V	MESDC2_uc002bfx.2_RNA|MESDC2_uc010uno.1_RNA	NM_015154	NP_055969	Q14696	MESD_HUMAN	mesoderm development candidate 2	30	Chaperone domain (By similarity).				mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum					0						CGCGCAGGACCCAGGCGGTGG	0.567													1	0	3.5997e-14	0.002299	3.80161e-14	21	44										A	81282044	C	A	81282044	3	1	117	1	0	0	0	0	1	0	0	0	9481	623	22	4	627	4	MESDC2	15	81282044	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	5349631	81282044	21249348	412	35402										
SEMA4B	10509	broad.mit.edu	37	chr15	90764303	90764303	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtcccttcgacccgaatttCaagtccactgccctggtggt	9	14	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:90764303C>G	uc002boy.2	+	6	856	c.573C>G	c.(571-573)TTC>TTG	p.F191L	SEMA4B_uc002boz.2_Missense_Mutation_p.F191L|SEMA4B_uc010uqd.1_Missense_Mutation_p.F29L|SEMA4B_uc002bpa.2_Missense_Mutation_p.F29L|SEMA4B_uc010bnv.1_5'Flank	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			ACCCGAATTTCAAGTCCACTG	0.572											OREG0023469	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	11	5										G	90764303	C	G	90764303	3	3	117	1	0	0	0	0	1	0	0	0	14032	825	29	1	591	1	SEMA4B	15	90764303	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	9482259	90764303	11767089	413	35403										
FURIN	5045	broad.mit.edu	37	chr15	91423349	91423349	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcgggaaacggctcgaggtgCggaagaccgtgaccgcgtgc	17	11	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:91423349C>T	uc002bpu.1	+	13	1618	c.1402C>T	c.(1402-1404)CGG>TGG	p.R468W		NM_002569	NP_002560	P09958	FURIN_HUMAN	furin preproprotein	468					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			central_nervous_system(4)|lung(2)|breast(1)	7	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GCTCGAGGTGCGGAAGACCGT	0.667													0	0	0	0.001855	0	10	40										T	91423349	C	T	91423349	3	4	117	1	0	0	0	0	1	0	0	0	6099	759	27	2	1448	2	FURIN	15	91423349	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	659046	91423349	11108043	414	35404										
OR4F15	390649	broad.mit.edu	37	chr15	102358647	102358647	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagatgatttgtgatattttCaagaagcacaaggccatctc	8	7	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr15:102358647C>G	uc010uts.1	+	1	258	c.258C>G	c.(256-258)TTC>TTG	p.F86L		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			GTGATATTTTCAAGAAGCACA	0.463													0	0	0	0.010504	0	22	84										G	102358647	C	G	102358647	3	3	117	1	0	0	0	0	1	0	0	0	11061	825	29	1	260	1	OR4F15	15	102358647	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	10935298	102358647	172745	415	35405										
RAB40C	57799	broad.mit.edu	37	chr16	677451	677451	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagagccacctcaagtccttCtcgatggccaacggcatgaa	9	13	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:677451C>T	uc002chr.2	+	6	791	c.675C>T	c.(673-675)TTC>TTT	p.F225F	RAB40C_uc002chq.2_Silent_p.F206F|WFIKKN1_uc002chs.1_5'Flank	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	225	SOCS box.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)				TCAAGTCCTTCTCGATGGCCA	0.652													0	0	0	0.00361	0	54	172										T	677451	C	T	677451	2	4	117	1	0	0	0	0	0	0	0	1	12942	912	32	1		1	RAB40C	16	677451	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		677451	89677302	416	35406										
CASKIN1	57524	broad.mit.edu	37	chr16	2237255	2237255	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtctggctgtaggtgttcctCacgtgggcattgatcccgct	13	11	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:2237255C>A	uc010bsg.1	-	8	779	c.747G>T	c.(745-747)GTG>GTT	p.V249V		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	249	ANK 6.				signal transduction	cytoplasm				skin(2)	2						AGGTGTTCCTCACGTGGGCAT	0.632													1	0	6.00712e-18	0.012213	6.46845e-18	27	73										A	2237255	C	A	2237255	2	1	117	1	0	0	0	0	0	0	0	1	2666	813	29	3		3	CASKIN1	16	2237255	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1559804	2237255	88117498	417	35407										
THOC6	79228	broad.mit.edu	37	chr16	3076366	3076366	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccttgcctttccttccccagGaccagcctggaagtgcctga	9	16	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:3076366G>C	uc002ctb.2	+	6	659	c.363G>C	c.(361-363)AGG>AGC	p.R121S	HCFC1R1_uc002csx.1_5'Flank|HCFC1R1_uc002csy.1_5'Flank|HCFC1R1_uc002csz.1_5'Flank|THOC6_uc002ctd.2_Missense_Mutation_p.R121S|THOC6_uc002ctc.2_Missense_Mutation_p.R97S|THOC6_uc002cta.2_Missense_Mutation_p.R97S	NM_024339	NP_077315	Q86W42	THOC6_HUMAN	WD repeat domain 58 isoform 1	121				R -> S (in Ref. 1; BAG36782).	intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			ovary(1)|central_nervous_system(1)	2						CCTTCCCCAGGACCAGCCTGG	0.572													0	0	0	0.007413	0	15	40										C	3076366	G	C	3076366	3	2	117	1	0	0	0	0	1	0	0	0	15866	1188	41	1	385	1	THOC6	16	3076366	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	839111	3076366	87278387	418	35408										
DNAH3	55567	broad.mit.edu	37	chr16	21128567	21128567	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgaaataccttgaaagtttGaatcaaaaaatcagaaacaa	5	6	2	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:21128567G>C	uc010vbe.1	-	12	1771	c.1771C>G	c.(1771-1773)CAA>GAA	p.Q591E	DNAH3_uc002die.2_Missense_Mutation_p.Q531E	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	591	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGAAAGTTTGAATCAAAAAA	0.363													0	0	0	0.000602	0	4	58										C	21128567	G	C	21128567	3	2	117	1	0	0	0	0	1	0	0	0	4603	1299	45	1	10782	1	DNAH3	16	21128567	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	18052201	21128567	69226186	419	35409										
ERN2	10595	broad.mit.edu	37	chr16	23724503	23724503	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctcgaccccctgaccgcactCgccatagcgcctgggcagct	10	19	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:23724503C>T	uc002dma.3	-	1	319	c.150G>A	c.(148-150)GCG>GCA	p.A50A	ERN2_uc010bxp.2_Silent_p.A50A|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	2					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGACCGCACTCGCCATAGCGC	0.736													0	0	0	0.004482	0	7	5										T	23724503	C	T	23724503	2	4	117	1	0	0	0	0	0	0	0	1	5238	871	31	1		1	ERN2	16	23724503	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2595936	23724503	66630250	420	35410										
XPO6	23214	broad.mit.edu	37	chr16	28145186	28145186	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtggagaaggcgtgcgtgggCaggagctccatcactttggc	17	9	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:28145186C>T	uc002dpa.1	-	11	2013	c.1512G>A	c.(1510-1512)CTG>CTA	p.L504L	XPO6_uc002dpb.1_Silent_p.L490L|XPO6_uc010vcp.1_Silent_p.L504L	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	504					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						CGTGCGTGGGCAGGAGCTCCA	0.587													0	0	0	0.00361	0	72	48										T	28145186	C	T	28145186	2	4	117	1	0	0	0	0	0	0	0	1	17445	697	25	2		2	XPO6	16	28145186	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4420683	28145186	62209567	421	35411										
RNF40	9810	broad.mit.edu	37	chr16	30775620	30775620	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcaaggccgaatggagttctCcaaggcagctgtgtctcgtg	14	10	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:30775620C>G	uc002dzq.2	+	5	686	c.563C>G	c.(562-564)TCC>TGC	p.S188C	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Missense_Mutation_p.S188C|RNF40_uc010cab.2_Missense_Mutation_p.S188C|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Missense_Mutation_p.S188C|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	188					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			ATGGAGTTCTCCAAGGCAGCT	0.627													0	0	0	0.007413	0	14	57										G	30775620	C	G	30775620	3	3	117	1	0	0	0	0	1	0	0	0	13493	855	30	1	577	1	RNF40	16	30775620	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2630434	30775620	59579133	422	35412										
RNF40	9810	broad.mit.edu	37	chr16	30776275	30776275	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccaggggacagtgagcccctCagtgaggcggctcaggcaca	15	13	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:30776275C>G	uc002dzq.2	+	6	789	c.666C>G	c.(664-666)CTC>CTG	p.L222L	C16orf93_uc002dzm.2_5'Flank|C16orf93_uc002dzn.2_5'Flank|C16orf93_uc002dzo.2_5'Flank|C16orf93_uc002dzp.2_5'Flank|RNF40_uc010caa.2_Silent_p.L222L|RNF40_uc010cab.2_Silent_p.L222L|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Silent_p.L222L|RNF40_uc010vfb.1_Intron	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	222	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GTGAGCCCCTCAGTGAGGCGG	0.602													0	0	0	0.010504	0	16	81										G	30776275	C	G	30776275	2	3	117	1	0	0	0	0	0	0	0	1	13493	813	29	1		1	RNF40	16	30776275	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	655	30776275	59578478	423	35413										
LONP2	83752	broad.mit.edu	37	chr16	48286132	48286132	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	attacaggcctatgccgtttCcagattgtacaggtcttaaa	8	9	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:48286132C>G	uc002efi.1	+	2	413	c.324C>G	c.(322-324)TTC>TTG	p.F108L	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Missense_Mutation_p.F108L	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	108	Lon.				misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						TATGCCGTTTCCAGATTGTAC	0.502													0	0	0	0.008871	0	17	16										G	48286132	C	G	48286132	3	3	117	1	0	0	0	0	1	0	0	0	8893	854	30	1	330	1	LONP2	16	48286132	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	17509857	48286132	42068621	424	35414										
IRX6	79190	broad.mit.edu	37	chr16	55363210	55363210	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtagtgcagtgccagtacccGtctggagcagaaggtagtgg	16	8	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:55363210G>C	uc002ehy.2	+	5	1853	c.1320G>C	c.(1318-1320)CCG>CCC	p.P440P	IRX6_uc002ehx.2_Silent_p.P440P	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	440						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						GCCAGTACCCGTCTGGAGCAG	0.627													0	0	0	0.009096	0	3	51										C	55363210	G	C	55363210	2	2	117	1	0	0	0	0	0	0	0	1	7848	1132	40	4		4	IRX6	16	55363210	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	7077078	55363210	34991543	425	35415										
CCDC135	84229	broad.mit.edu	37	chr16	57731954	57731954	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgggcgaggatggagaaaatGatgaggccagttgaggtgcg	19	4	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:57731954G>A	uc002emi.2	+	2	182	c.93G>A	c.(91-93)ATG>ATA	p.M31I	CCDC135_uc002emj.2_Missense_Mutation_p.M31I|CCDC135_uc002emk.2_Missense_Mutation_p.M31I	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	31	Potential.					cytoplasm				central_nervous_system(1)	1						TGGAGAAAATGATGAGGCCAG	0.438													0	0	0	0.008291	0	10	13										A	57731954	G	A	57731954	3	1	117	1	0	0	0	0	1	0	0	0	2769	1290	45	1	95	1	CCDC135	16	57731954	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2368744	57731954	32622799	426	35416										
CDH5	1003	broad.mit.edu	37	chr16	66423281	66423281	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gacgtattatcacaataacgAaaagcttggaccgagagaag	10	7	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:66423281A>C	uc002eom.3	+	5	793	c.637A>C	c.(637-639)AAA>CAA	p.K213Q	CDH5_uc002eon.1_Missense_Mutation_p.K213Q	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	213	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CACAATAACGAAAAGCTTGGA	0.443													0	0	0	0.006122	0	14	32										C	66423281	A	C	66423281	3	2	117	1	0	0	0	0	1	0	0	0	3113	247	9	5	651	5	CDH5	16	66423281	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	8691327	66423281	23931472	427	35417										
CDH5	1003	broad.mit.edu	37	chr16	66431938	66431938	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tccacattgaagttttggatGagaatgacaatgccccggag	11	8	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:66431938G>A	uc002eom.3	+	9	1570	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	472	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGTTTTGGATGAGAATGACAA	0.542													0	0	0	0.00361	0	72	96										A	66431938	G	A	66431938	3	1	117	1	0	0	0	0	1	0	0	0	3113	1291	45	1	1444	1	CDH5	16	66431938	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8657	66431938	23922815	428	35418										
SLC7A6	9057	broad.mit.edu	37	chr16	68325477	68325477	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccagacatttgctgaccagaCgtttggcatgttcagctgga	11	10	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:68325477C>T	uc002evt.1	+	8	1244	c.935C>T	c.(934-936)ACG>ATG	p.T312M	SLC7A6_uc010cfb.1_RNA|SLC7A6_uc002evu.1_Missense_Mutation_p.T312M|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	312	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GCTGACCAGACGTTTGGCATG	0.502													0	0	0	0.00361	0	67	79										T	68325477	C	T	68325477	3	4	117	1	0	0	0	0	1	0	0	0	14701	536	19	2	953	2	SLC7A6	16	68325477	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1893539	68325477	22029276	429	35419										
PRMT7	54496	broad.mit.edu	37	chr16	68389659	68389659	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcagggagagcagggaagctGagccccacccgctgtgggag	17	11	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:68389659G>C	uc002evy.1	+	17	1960	c.1684G>C	c.(1684-1686)GAG>CAG	p.E562Q	PRMT7_uc010vlg.1_Missense_Mutation_p.E512Q|PRMT7_uc002evz.1_Missense_Mutation_p.E334Q|PRMT7_uc010cfd.1_Missense_Mutation_p.E54Q	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	562					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		CAGGGAAGCTGAGCCCCACCC	0.677													0	0	0	0.006214	0	10	8										C	68389659	G	C	68389659	3	2	117	1	0	0	0	0	1	0	0	0	12541	1291	45	1	1742	1	PRMT7	16	68389659	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	64182	68389659	21965094	430	35420										
COG8	84342	broad.mit.edu	37	chr16	69368866	69368866	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccagcacctgcaggaattgtGagaccttctgtagcacccag	10	13	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:69368866G>C	uc002ewy.2	-	3	1042	c.971C>G	c.(970-972)TCA>TGA	p.S324*	COG8_uc002ewz.3_Nonsense_Mutation_p.S324*	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	324					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						CAGGAATTGTGAGACCTTCTG	0.592													0	0	0	0.005443	0	25	59										C	69368866	G	C	69368866	4	2	117	1	0	0	0	0	0	1	0	0	3664	1294	45	1	879	1	COG8	16	69368866	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	979207	69368866	20985887	431	35421										
COG8	84342	broad.mit.edu	37	chr16	69370435	69370435	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acagggatggaagagtatttCctctccagtcggcgtacgta	12	9	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:69370435C>T	uc002ewy.2	-	2	629	c.558G>A	c.(556-558)AGG>AGA	p.R186R	COG8_uc002ewz.3_Silent_p.R186R	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	186					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						AAGAGTATTTCCTCTCCAGTC	0.488													0	0	0	0.001368	0	9	36										T	69370435	C	T	69370435	2	4	117	1	0	0	0	0	0	0	0	1	3664	854	30	1		1	COG8	16	69370435	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1569	69370435	20984318	432	35422										
COG8	84342	broad.mit.edu	37	chr16	69373450	69373450	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gatgggatagtcgccgcggtCgccatcttcccagcaacaac	11	14	1	0	rs142062440		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:69373450C>T	uc002ewy.2	-	1	77	c.6G>A	c.(4-6)GCG>GCA	p.A2A	COG8_uc002ewz.3_Silent_p.A2A|NIP7_uc002exa.2_5'Flank|NIP7_uc002exb.2_5'Flank	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	2					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						TCGCCGCGGTCGCCATCTTCC	0.622											OREG0023907	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	17	25										T	69373450	C	T	69373450	2	4	117	1	0	0	0	0	0	0	0	1	3664	871	31	1		1	COG8	16	69373450	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3015	69373450	20981303	433	35423										
BANP	54971	broad.mit.edu	37	chr16	88017774	88017774	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccttagaagaaaagctggatCtggtcacgaacaagcagcac	10	10	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:88017774C>G	uc002fkr.2	+	4	468	c.244C>G	c.(244-246)CTG>GTG	p.L82V	BANP_uc002fkp.2_Missense_Mutation_p.L91V|BANP_uc002fkq.2_Missense_Mutation_p.L91V|BANP_uc010vow.1_Missense_Mutation_p.L90V|BANP_uc002fks.3_Missense_Mutation_p.L90V|BANP_uc002fko.1_Translation_Start_Site|BANP_uc010vov.1_Missense_Mutation_p.L96V	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b	83	Potential.				cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		AAAGCTGGATCTGGTCACGAA	0.527													0	0	0	0.000602	0	4	5										G	88017774	C	G	88017774	3	3	117	1	0	0	0	0	1	0	0	0	1310	912	32	1	299	1	BANP	16	88017774	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	18644324	88017774	2336979	434	35424										
ANKRD11	29123	broad.mit.edu	37	chr16	89349651	89349651	+	Frame_Shift_Del	DEL	G	G	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcttgtcatcttttttttcaGagaagtcttctgagatgatc							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:89349651delG	uc002fmx.1	-	9	3760	c.3299delC	c.(3298-3300)TCTfs	p.S1100fs	ANKRD11_uc002fmy.1_Frame_Shift_Del_p.S1100fs|ANKRD11_uc002fnc.1_Frame_Shift_Del_p.S1100fs|ANKRD11_uc002fnb.1_Frame_Shift_Del_p.S1057fs	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1100	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTTTTTTTCAGAGAAGTCTTC	0.463																		22	39	---	---								-	89349651	G	-	89349651	7	5	117	1	0	1	0	1	0	0	0	0	639	942	33	0	4712	0	ANKRD11	16	89349651	Frame_Shift_Del	DEL	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1331877	89349651	1005102	435	35425										
ANKRD11	29123	broad.mit.edu	37	chr16	89352493	89352493	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	taagtgcctttgcctaacagGaggttcaccatcgtggggga	13	9	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr16:89352493G>A	uc002fmx.1	-	8	1307	c.846C>T	c.(844-846)CTC>CTT	p.L282L	ANKRD11_uc002fmy.1_Silent_p.L282L|ANKRD11_uc002fnc.1_Silent_p.L282L|ANKRD11_uc002fnb.1_Silent_p.L239L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	282	ANK 4.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TGCCTAACAGGAGGTTCACCA	0.587													0	0	0	0.00361	0	68	74										A	89352493	G	A	89352493	2	1	117	1	0	0	0	0	0	0	0	1	639	1161	41	1		1	ANKRD11	16	89352493	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2842	89352493	1002260	436	35426										
SMYD4	114826	broad.mit.edu	37	chr17	1690794	1690794	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gacagtgctaatgaaggacaCgctggtgttggggctacagg	16	7	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:1690794C>G	uc002ftm.3	-	6	1810	c.1642G>C	c.(1642-1644)GTG>CTG	p.V548L	SMYD4_uc002ftn.1_Missense_Mutation_p.V403L	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	548	SET.						zinc ion binding			skin(3)|kidney(2)	5						ATGAAGGACACGCTGGTGTTG	0.577													0	0	0	0.004672	0	3	18										G	1690794	C	G	1690794	3	3	117	1	0	0	0	0	1	0	0	0	14824	536	19	4	796	4	SMYD4	17	1690794	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		1690794	79504416	437	35427										
CAMTA2	23125	broad.mit.edu	37	chr17	4876991	4876991	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccagacgttcaggacccttcCaggtggagcgtgggatcatg	14	11	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:4876991C>T	uc002gah.1	-	13	2198	c.2090G>A	c.(2089-2091)TGG>TAG	p.W697*	CAMTA2_uc010cku.1_Nonsense_Mutation_p.W720*|CAMTA2_uc002gag.1_Nonsense_Mutation_p.W696*|CAMTA2_uc002gai.1_Nonsense_Mutation_p.W699*|CAMTA2_uc010ckv.1_Nonsense_Mutation_p.W344*	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	697					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						AGGACCCTTCCAGGTGGAGCG	0.612													0	0	0	0.012319	0	17	103										T	4876991	C	T	4876991	4	4	117	1	0	0	0	0	0	1	0	0	2614	595	21	2	1612	2	CAMTA2	17	4876991	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3186197	4876991	76318219	438	35428										
GPR172B	55065	broad.mit.edu	37	chr17	4937171	4937171	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaaggcggcagctgaagtgaCcagaagggcagtcagtgccc	16	10	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:4937171C>G	uc002gap.3	-	3	1326	c.613G>C	c.(613-615)GTC>CTC	p.V205L	GPR172B_uc002gao.3_Missense_Mutation_p.V205L|GPR172B_uc010ckw.2_Missense_Mutation_p.V83L|GPR172B_uc010ckx.2_Missense_Mutation_p.V205L	NM_001104577	NP_001098047	Q9NWF4	RFT_HUMAN	G protein-coupled receptor 172B precursor	205	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0						GCTGAAGTGACCAGAAGGGCA	0.622													0	0	0	0.004878	0	30	189										G	4937171	C	G	4937171	3	3	117	1	0	0	0	0	1	0	0	0	6670	507	18	4	745	4	GPR172B	17	4937171	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	60180	4937171	76258039	439	35429										
C17orf74	201243	broad.mit.edu	37	chr17	7330189	7330189	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccctaacccctcttgggtCcccgtggggcacagccctta	9	19	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7330189C>T	uc002ggw.2	+	3	952	c.879C>T	c.(877-879)GTC>GTT	p.V293V	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	293						integral to membrane					0		Prostate(122;0.157)				CCTCTTGGGTCCCCGTGGGGC	0.677													0	0	0	0.008871	0	18	102										T	7330189	C	T	7330189	2	4	117	1	0	0	0	0	0	0	0	1	1879	842	30	1		1	C17orf74	17	7330189	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2393018	7330189	73865021	440	35430										
TP53	7157	broad.mit.edu	37	chr17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttccactcggataagatgctGaggaggggccagacctaaga	13	9	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	87	8										A	7578275	G	A	7578275	4	1	117	1	0	0	0	0	0	1	0	0	16378	1299	45	1	720	1	TP53	17	7578275	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	248086	7578275	73616935	441	35431										
DNAH2	146754	broad.mit.edu	37	chr17	7696168	7696168	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgctcgttgtcaacatgtccGcacaggtgtgtcggggatcc	13	11	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:7696168G>A	uc002giu.1	+	46	7353	c.7339G>A	c.(7339-7341)GCA>ACA	p.A2447T		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2447	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CAACATGTCCGCACAGGTGTG	0.647													0	0	0	0.000602	0	4	167										A	7696168	G	A	7696168	3	1	117	1	0	0	0	0	1	0	0	0	4602	1087	38	2	7521	2	DNAH2	17	7696168	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	117893	7696168	73499042	442	35432										
PER1	5187	broad.mit.edu	37	chr17	8045717	8045717	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccccgagcagccccagcctCagcctcggaagagtcgatgc	12	17	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:8045717C>T	uc002gkd.2	-	21	3557	c.3319G>A	c.(3319-3321)GAG>AAG	p.E1107K	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_RNA	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	1107					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						gccccagcctcagcctcggAA	0.443			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					0	0	0	0.012213	0	30	1										T	8045717	C	T	8045717	3	4	117	1	0	0	0	0	1	0	0	0	11729	835	29	1	565	1	PER1	17	8045717	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	349549	8045717	73149493	443	35433										
PER1	5187	broad.mit.edu	37	chr17	8048196	8048196	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agggacagcacggccttggtCagccccactggacggtaggc	15	13	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:8048196C>G	uc002gkd.2	-	18	2572	c.2334G>C	c.(2332-2334)CTG>CTC	p.L778L	PER1_uc010cns.2_5'Flank|PER1_uc010vuq.1_RNA|PER1_uc010vur.1_Silent_p.L762L	NM_002616	NP_002607	O15534	PER1_HUMAN	period 1	778	CSNK1E binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			lung(2)|breast(2)|skin(2)|large_intestine(1)|ovary(1)|kidney(1)	9						CGGCCTTGGTCAGCCCCACTG	0.433			T	ETV6	AML|CMML			Other_conserved_DNA_damage_response_genes					0	0	0	0.008871	0	19	2										G	8048196	C	G	8048196	2	3	117	1	0	0	0	0	0	0	0	1	11729	813	29	1		1	PER1	17	8048196	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2479	8048196	73147014	444	35434										
RCVRN	5957	broad.mit.edu	37	chr17	9808346	9808346	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggaagaacttggcgtagatgCtctggaactgctgctgggtg	16	7	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:9808346C>T	uc002gme.1	-	1	339	c.152G>A	c.(151-153)AGC>AAC	p.S51N		NM_002903	NP_002894	P35243	RECO_HUMAN	recoverin	51	EF-hand 1.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						GGCGTAGATGCTCTGGAACTG	0.602													0	0	0	0.001984	0	6	12										T	9808346	C	T	9808346	3	4	117	1	0	0	0	0	1	0	0	0	13186	797	28	2	462	2	RCVRN	17	9808346	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1760150	9808346	71386864	445	35435										
SUPT6H	6830	broad.mit.edu	37	chr17	27011877	27011877	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcagagatcaccctgtgttCtgcgccctggtcaatggtga	13	11	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:27011877C>G	uc002hby.2	+	19	2475	c.2385C>G	c.(2383-2385)TTC>TTG	p.F795L	SUPT6H_uc010crt.2_Missense_Mutation_p.F795L	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	795					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ACCCTGTGTTCTGCGCCCTGG	0.443													0	0	0	0.00361	0	93	42										G	27011877	C	G	27011877	3	3	117	1	0	0	0	0	1	0	0	0	15397	912	32	1	2455	1	SUPT6H	17	27011877	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	17203531	27011877	54183333	446	35436										
ZNF207	7756	broad.mit.edu	37	chr17	30678846	30678846	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgatgagaagatccttattcAgcaccaaaaagcaaagcatt	7	8	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:30678846A>G	uc002hhh.3	+	2	231	c.83A>G	c.(82-84)CAG>CGG	p.Q28R	ZNF207_uc002hhj.3_Missense_Mutation_p.Q28R|ZNF207_uc002hhi.3_Missense_Mutation_p.Q28R|ZNF207_uc010csz.2_Missense_Mutation_p.Q31R|ZNF207_uc002hhk.1_Missense_Mutation_p.Q28R	NM_003457	NP_003448	O43670	ZN207_HUMAN	zinc finger protein 207 isoform a	28	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			ATCCTTATTCAGCACCAAAAA	0.343													0	0	0	0.007835	0	38	47										G	30678846	A	G	30678846	3	3	117	1	0	0	0	0	1	0	0	0	17762	188	7	5	89	5	ZNF207	17	30678846	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	3666969	30678846	50516364	447	35437										
GGNBP2	79893	broad.mit.edu	37	chr17	34937963	34937963	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgaaaaggaagtaagccaaGagaaggtaatatttcttaat	9	3	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:34937963G>A	uc002hnb.2	+	9	1459	c.1210G>A	c.(1210-1212)GAG>AAG	p.E404K	GGNBP2_uc002hna.2_Missense_Mutation_p.E404K|GGNBP2_uc002hnc.1_Missense_Mutation_p.E233K	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403	404					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AGTAAGCCAAGAGAAGGTAAT	0.279													0	0	0	0.004656	0	22	35										A	34937963	G	A	34937963	3	1	117	1	0	0	0	0	1	0	0	0	6359	943	33	1	1240	1	GGNBP2	17	34937963	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4259117	34937963	46257247	448	35438										
MLLT6	4302	broad.mit.edu	37	chr17	36875796	36875796	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acctggaggactgcagcttcCggtgtcgggggacctcccct	14	14	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:36875796C>T	uc002hqi.3	+	13	1982	c.1969C>T	c.(1969-1971)CGG>TGG	p.R657W	MLLT6_uc002hqj.2_Missense_Mutation_p.R92W|MLLT6_uc002hqk.3_5'UTR	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	657					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					CTGCAGCTTCCGGTGTCGGGG	0.657			T	MLL	AL								0	0	0	0.010504	0	16	35										T	36875796	C	T	36875796	3	4	117	1	0	0	0	0	1	0	0	0	9630	643	23	2	2019	2	MLLT6	17	36875796	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1937833	36875796	44319414	449	35439										
TCAP	8557	broad.mit.edu	37	chr17	37822334	37822334	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcgtcgctccctgtcccgctCcatgtcccaggaagcacaga	9	17	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:37822334C>T	uc002hsh.2	+	2	490	c.476C>T	c.(475-477)TCC>TTC	p.S159F	PNMT_uc002hsi.1_5'Flank	NM_003673	NP_003664	O15273	TELT_HUMAN	telethonin	159					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding				0	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGTCCCGCTCCATGTCCCAG	0.657													0	0	0	0.00361	0	129	166										T	37822334	C	T	37822334	3	4	117	1	0	0	0	0	1	0	0	0	15663	855	30	1	482	1	TCAP	17	37822334	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	946538	37822334	43372876	450	35440										
GSDMA	284110	broad.mit.edu	37	chr17	38130640	38130640	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctcagctccctcagcaaacTtctagggaagaaaaaggagc	10	11	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:38130640T>G	uc002htl.1	+	9	984	c.866T>G	c.(865-867)CTT>CGT	p.L289R	GSDMA_uc002htm.1_Missense_Mutation_p.L289R	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	289					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						CTCAGCAAACTTCTAGGGAAG	0.512													0	0	0	0.004672	0	3	20										G	38130640	T	G	38130640	3	3	117	1	0	0	0	0	1	0	0	0	6816	1609	56	5	896	5	GSDMA	17	38130640	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	308306	38130640	43064570	451	35441										
KLHL10	317719	broad.mit.edu	37	chr17	40004197	40004197	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atccacaggtaggtggctttGatggagctaatcgacttagg	13	7	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:40004197G>C	uc010cxr.2	+	5	1607	c.1465G>C	c.(1465-1467)GAT>CAT	p.D489H	KLHL10_uc010wfw.1_Missense_Mutation_p.D401H	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	489	Kelch 5.					cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)				AGGTGGCTTTGATGGAGCTAA	0.483													0	0	0	0.00361	0	86	113										C	40004197	G	C	40004197	3	2	117	1	0	0	0	0	1	0	0	0	8366	1290	45	1	1483	1	KLHL10	17	40004197	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1873557	40004197	41191013	452	35442										
EFCAB3	146779	broad.mit.edu	37	chr17	60493508	60493508	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgacaccttttctacttatAcatggtcctggaatgtttgc	7	9	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:60493508A>G	uc002izu.1	+	10	1213	c.1135A>G	c.(1135-1137)ACA>GCA	p.T379A	EFCAB3_uc010wpc.1_Missense_Mutation_p.T431A	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	379							calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			TTCTACTTATACATGGTCCTG	0.408													0	0	0	0.00361	0	46	54										G	60493508	A	G	60493508	3	3	117	1	0	0	0	0	1	0	0	0	4935	391	14	5	1337	5	EFCAB3	17	60493508	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	20489311	60493508	20701702	453	35443										
TACO1	51204	broad.mit.edu	37	chr17	61678640	61678640	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacaacaagtggtccaaagtCaggcacatcaagggtccgaa	10	11	2	0	rs141350830		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:61678640C>T	uc002jbd.2	+	1	398	c.198C>T	c.(196-198)GTC>GTT	p.V66V		NM_016360	NP_057444	Q9BSH4	TACO1_HUMAN	translational activator of mitochondrially	66					regulation of translation	mitochondrion					0						GGTCCAAAGTCAGGCACATCA	0.637													0	0	0	0.00632	0	25	36										T	61678640	C	T	61678640	2	4	117	1	0	0	0	0	0	0	0	1	15501	813	29	1		1	TACO1	17	61678640	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1185132	61678640	19516570	454	35444										
SMURF2	64750	broad.mit.edu	37	chr17	62543775	62543775	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggatcctgtcacaaactgaaGcaatcttgctcgtcgctctt	8	12	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:62543775G>C	uc002jep.1	-	17	2402	c.2014C>G	c.(2014-2016)CTT>GTT	p.L672V	SMURF2_uc002jeq.1_Missense_Mutation_p.L431V|SMURF2_uc002jer.1_Missense_Mutation_p.L431V	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	672	HECT.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			ACAAACTGAAGCAATCTTGCT	0.517													0	0	0	0.00361	0	101	106										C	62543775	G	C	62543775	3	2	117	1	0	0	0	0	1	0	0	0	14820	971	34	4	244	4	SMURF2	17	62543775	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	865135	62543775	18651435	455	35445										
FAM20A	54757	broad.mit.edu	37	chr17	66535515	66535515	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggcgagaggatggagatttCatcatgggagtgtcgtccga	16	6	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:66535515C>T	uc002jho.2	-	10	1612	c.1324G>A	c.(1324-1326)GAA>AAA	p.E442K	FAM20A_uc010wqp.1_Missense_Mutation_p.E304K|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.E153K	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	442						extracellular region					0	Breast(10;1.64e-13)					ATGGAGATTTCATCATGGGAG	0.527													0	0	0	0.00361	0	36	159										T	66535515	C	T	66535515	3	4	117	1	0	0	0	0	1	0	0	0	5537	835	29	1	309	1	FAM20A	17	66535515	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3991740	66535515	14659695	456	35446										
SDK2	54549	broad.mit.edu	37	chr17	71391400	71391400	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtccactcctccaggtcctcGatggtgtagtcccgctccac	9	17	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:71391400G>A	uc010dfm.2	-	25	3486	c.3486C>T	c.(3484-3486)ATC>ATT	p.I1162I	SDK2_uc002jjt.3_Silent_p.I321I|SDK2_uc010dfn.2_Silent_p.I841I	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1162	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion	integral to membrane				ovary(2)	2						CCAGGTCCTCGATGGTGTAGT	0.652													0	0	0	0.010729	0	11	59										A	71391400	G	A	71391400	2	1	117	1	0	0	0	0	0	0	0	1	13969	1048	37	1		1	SDK2	17	71391400	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4855885	71391400	9803810	457	35447										
FDXR	2232	broad.mit.edu	37	chr17	72860373	72860373	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcggaggccccaggcacggGaggccgatgcctggcgggca	19	13	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:72860373G>A	uc002jly.2	-	9	986	c.899C>T	c.(898-900)TCC>TTC	p.S300F	FDXR_uc010wri.1_Missense_Mutation_p.S248F|FDXR_uc010wrj.1_Missense_Mutation_p.S298F|FDXR_uc002jlw.2_Missense_Mutation_p.S57F|FDXR_uc002jlx.2_Missense_Mutation_p.S306F|FDXR_uc002jmc.2_Missense_Mutation_p.S272F|FDXR_uc010wrk.1_Missense_Mutation_p.S331F|FDXR_uc010wrl.1_Missense_Mutation_p.S343F|FDXR_uc002jma.2_Missense_Mutation_p.S301F|FDXR_uc010wrm.1_Missense_Mutation_p.S260F|FDXR_uc002jlz.2_Missense_Mutation_p.S292F|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	300					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CCAGGCACGGGAGGCCGATGC	0.692													0	0	0	0.00623	0	35	41										A	72860373	G	A	72860373	3	1	117	1	0	0	0	0	1	0	0	0	5807	1174	41	1	592	1	FDXR	17	72860373	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1468973	72860373	8334837	458	35448										
CDK3	1018	broad.mit.edu	37	chr17	73998377	73998377	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgagtttctgccactcacatCgggtcatccaccgagacctg	9	14	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:73998377C>T	uc010dgt.2	+	5	440	c.364C>T	c.(364-366)CGG>TGG	p.R122W	CDK3_uc002jqg.3_Missense_Mutation_p.R150W	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	122	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						CCACTCACATCGGGTCATCCA	0.627													0	0	0	0.00361	0	77	82										T	73998377	C	T	73998377	3	4	117	1	0	0	0	0	1	0	0	0	3140	875	31	1	378	1	CDK3	17	73998377	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1138004	73998377	7196833	459	35449										
UBE2O	63893	broad.mit.edu	37	chr17	74396299	74396299	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccaggcaatcttggctggctCtaccttggctgggaagacat	12	11	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:74396299C>T	uc002jrm.3	-	8	1149	c.1084G>A	c.(1084-1086)GAG>AAG	p.E362K	UBE2O_uc002jrn.3_Missense_Mutation_p.E362K|UBE2O_uc002jrl.3_5'Flank	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	362							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						TTGGCTGGCTCTACCTTGGCT	0.582													0	0	0	0.00361	0	53	84										T	74396299	C	T	74396299	3	4	117	1	0	0	0	0	1	0	0	0	16865	922	32	1	2838	1	UBE2O	17	74396299	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	397922	74396299	6798911	460	35450										
NPTX1	4884	broad.mit.edu	37	chr17	78449360	78449360	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agggaggtcagggcggtctcGatcttgaccctctcctcggt	14	12	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:78449360G>T	uc002jyp.1	-	2	761	c.603C>A	c.(601-603)ATC>ATA	p.I201I		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	201					central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GGGCGGTCTCGATCTTGACCC	0.667													1	0	1.90571e-15	0.004289	2.01907e-15	32	53										T	78449360	G	T	78449360	2	4	117	1	0	0	0	0	0	0	0	1	10602	1048	37	3		3	NPTX1	17	78449360	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4053061	78449360	2745850	461	35451										
TMEM105	284186	broad.mit.edu	37	chr17	79287597	79287597	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcaggcccttcatgtcttcGccttcttatcttcatctcac	6	15	6	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr17:79287597G>A	uc002kad.1	-	3	794	c.244C>T	c.(244-246)CGA>TGA	p.R82*		NM_178520	NP_848615	Q8N8V8	TM105_HUMAN	transmembrane protein 105	82						integral to membrane				ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			TCATGTCTTCGCCTTCTTATC	0.662													0	0	0	0.00361	0	133	116										A	79287597	G	A	79287597	4	1	117	1	0	0	0	0	0	1	0	0	16016	1095	38	2	149	2	TMEM105	17	79287597	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	838237	79287597	1907613	462	35452										
CEP192	55125	broad.mit.edu	37	chr18	13092445	13092445	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catgtgtaaaattatactttCagtaattggagaattcagag	8	4	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:13092445C>T	uc010xac.1	+	34	6253	c.6173C>T	c.(6172-6174)TCA>TTA	p.S2058L	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.S1583L|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.S480L|CEP192_uc002krw.2_Missense_Mutation_p.S207L|CEP192_uc002krx.2_Missense_Mutation_p.S62L|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2058										ovary(4)|pancreas(1)	5						ATTATACTTTCAGTAATTGGA	0.333													0	0	0	0.010729	0	12	49										T	13092445	C	T	13092445	3	4	117	1	0	0	0	0	1	0	0	0	3251	838	29	1	6303	1	CEP192	18	13092445	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		13092445	64984803	463	35453										
ROCK1	6093	broad.mit.edu	37	chr18	18625257	18625257	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gcacttttatctttacctgtGaataaaacccatggaatgga	7	8	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:18625257G>A	uc002kte.2	-	5	1527	c.586C>T	c.(586-588)CAC>TAC	p.H196Y		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	196	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CTTTACCTGTGAATAAAACCC	0.343													0	0	0	0.00308	0	6	31										A	18625257	G	A	18625257	3	1	117	1	0	0	0	0	1	0	0	0	13517	1290	45	1	3594	1	ROCK1	18	18625257	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5532812	18625257	59451991	464	35454										
ZNF521	25925	broad.mit.edu	37	chr18	22806745	22806745	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccctcttcctccctcgactCtttgggattggcggggcagc	12	15	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:22806745C>T	uc002kvk.2	-	4	1384	c.1137G>A	c.(1135-1137)AAG>AAA	p.K379K	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.K379K|ZNF521_uc002kvl.2_Silent_p.K159K	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	379					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCCCTCGACTCTTTGGGATTG	0.532			T	PAX5	ALL								0	0	0	0.007291	0	20	77										T	22806745	C	T	22806745	2	4	117	1	0	0	0	0	0	0	0	1	17962	912	32	1		1	ZNF521	18	22806745	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	4181488	22806745	55270503	465	35455										
SS18	6760	broad.mit.edu	37	chr18	23612474	23612474	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gggtagttaggatactgaggAcctggaccaccctgtgaagg	15	8	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:23612474A>T	uc002kvm.2	-	10	1197	c.1119T>A	c.(1117-1119)GGT>GGA	p.G373G	SS18_uc002kvn.2_Silent_p.G342G|SS18_uc010xbf.1_Silent_p.G291G|SS18_uc010xbg.1_Silent_p.G290G|SS18_uc010xbh.1_Silent_p.G290G|SS18_uc010xbi.1_Silent_p.G350G	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	373	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					GATACTGAGGACCTGGACCAC	0.493			T	SSX1| SSX2	synovial sarcoma								0	0	0	0.003954	0	22	57										T	23612474	A	T	23612474	2	4	117	1	0	0	0	0	0	0	0	1	15174	262	10	5		5	SS18	18	23612474	Silent	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	805729	23612474	54464774	466	35456										
GALNT1	2589	broad.mit.edu	37	chr18	33243615	33243615	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tagagccagtacaaaagcctCatgaaggtcctggagaaatg	11	8	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:33243615C>T	uc010dmu.2	+	3	216	c.163C>T	c.(163-165)CAT>TAT	p.H55Y	GALNT1_uc002kyz.3_5'UTR|GALNT1_uc002kza.2_Missense_Mutation_p.H55Y|GALNT1_uc002kzb.2_Missense_Mutation_p.H55Y	NM_020474	NP_065207	Q10472	GALT1_HUMAN	polypeptide N-acetylgalactosaminyltransferase 1	55	Lumenal (Potential).				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						ACAAAAGCCTCATGAAGGTCC	0.328													0	0	0	0.003163	0	12	13										T	33243615	C	T	33243615	3	4	117	1	0	0	0	0	1	0	0	0	6207	826	29	1	169	1	GALNT1	18	33243615	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	9631141	33243615	44833633	467	35457										
KIAA0427	9811	broad.mit.edu	37	chr18	46287980	46287980	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	accgcagcttcgccttcaccGctgccaagctctgcgacaag	9	17	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:46287980G>A	uc002ldc.2	+	9	1576	c.1291G>A	c.(1291-1293)GCT>ACT	p.A431T	KIAA0427_uc002ldd.2_Missense_Mutation_p.A433T|KIAA0427_uc002lde.3_Missense_Mutation_p.A60T	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	431	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						CGCCTTCACCGCTGCCAAGCT	0.617													0	0	0	0.007835	0	35	100										A	46287980	G	A	46287980	3	1	117	1	0	0	0	0	1	0	0	0	8176	1087	38	2	1327	2	KIAA0427	18	46287980	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	13044365	46287980	31789268	468	35458										
LIPG	9388	broad.mit.edu	37	chr18	47101864	47101864	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcggcttgagcattggtattCagatgcctgtgggccacatt	12	9	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:47101864C>T	uc002ldv.2	+	5	949	c.697C>T	c.(697-699)CAG>TAG	p.Q233*	LIPG_uc002ldu.1_Nonsense_Mutation_p.Q233*|LIPG_uc010xdh.1_Intron	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	233					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						CATTGGTATTCAGATGCCTGT	0.532													0	0	0	0.007835	0	37	51										T	47101864	C	T	47101864	4	4	117	1	0	0	0	0	0	1	0	0	8823	827	29	1	715	1	LIPG	18	47101864	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	813884	47101864	30975384	469	35459										
CCDC11	220136	broad.mit.edu	37	chr18	47777950	47777950	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccaggcgtgtgttctccatCagctctttctgtctcctcgc	8	16	5	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:47777950C>G	uc002lee.2	-	4	769	c.678G>C	c.(676-678)CTG>CTC	p.L226L		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	226	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TGTTCTCCATCAGCTCTTTCT	0.552													0	0	0	0.00623	0	36	63										G	47777950	C	G	47777950	2	3	117	1	0	0	0	0	0	0	0	1	2746	813	29	1		1	CCDC11	18	47777950	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	676086	47777950	30299298	470	35460										
SOCS6	9306	broad.mit.edu	37	chr18	67992252	67992252	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccatagtctttaaagacgtGagagctcagaggccgataag	11	9	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr18:67992252G>A	uc002lkr.1	+	2	664	c.348G>A	c.(346-348)GTG>GTA	p.V116V	SOCS6_uc010dqq.2_Silent_p.V116V	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	116					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TTAAAGACGTGAGAGCTCAGA	0.597													0	0	0	0.010504	0	19	54										A	67992252	G	A	67992252	2	1	117	1	0	0	0	0	0	0	0	1	14918	1277	45	1		1	SOCS6	18	67992252	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	20214302	67992252	10084996	471	35461										
SHC2	25759	broad.mit.edu	37	chr19	418997	418997	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccacgatgggctgcccgttCtgcaggtggtggtcgatcag	16	11	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:418997C>G	uc002loq.3	-	12	1680	c.1680G>C	c.(1678-1680)CAG>CAC	p.Q560H	SHC2_uc002lop.3_Missense_Mutation_p.Q301H	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	560	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGCCCGTTCTGCAGGTGGT	0.677													0	0	0	0.001168	0	6	7										G	418997	C	G	418997	3	3	117	1	0	0	0	0	1	0	0	0	14271	912	32	1	72	1	SHC2	19	418997	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		418997	58709986	472	35462										
CNN2	1265	broad.mit.edu	37	chr19	1037770	1037770	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcttcggcctgggccggcaGatatatgaccccaagtactg	12	12	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:1037770G>C	uc002lqu.2	+	7	1164	c.801G>C	c.(799-801)CAG>CAC	p.Q267H	ABCA7_uc002lqw.3_5'Flank|CNN2_uc002lqv.2_Missense_Mutation_p.Q228H|CNN2_uc010xgb.1_Missense_Mutation_p.Q256H|CNN2_uc010xgc.1_Missense_Mutation_p.Q288H|ABCA7_uc010dsa.2_5'Flank	NM_004368	NP_004359	Q99439	CNN2_HUMAN	calponin 2 isoform a	267	Calponin-like 3.				actomyosin structure organization|cellular response to mechanical stimulus|regulation of actin filament-based process	cell-cell junction|stress fiber	actin binding|calmodulin binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGCCGGCAGATATATGACC	0.662													0	0	0	0.00361	0	41	69										C	1037770	G	C	1037770	3	2	117	1	0	0	0	0	1	0	0	0	3610	933	33	1	827	1	CNN2	19	1037770	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	618773	1037770	58091213	473	35463										
MUM1	84939	broad.mit.edu	37	chr19	1360523	1360523	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggaggtggtgcccaagatgaGagtgggtccagaatccacca	15	9	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:1360523G>C	uc010xgm.1	+	4	672	c.603G>C	c.(601-603)GAG>GAC	p.E201D	MUM1_uc010dsi.2_Missense_Mutation_p.E133D|MUM1_uc002lrz.2_Missense_Mutation_p.E202D|MUM1_uc002lsb.2_Missense_Mutation_p.E133D|MUM1_uc002lsc.1_Missense_Mutation_p.E133D			Q2TAK8	MUM1_HUMAN	SubName: Full=MUM1 protein;	201					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAAGATGAGAGTGGGTCCA	0.537											OREG0025088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	9	15										C	1360523	G	C	1360523	3	2	117	1	0	0	0	0	1	0	0	0	9985	933	33	1	620	1	MUM1	19	1360523	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	322753	1360523	57768460	474	35464										
LRRC8E	80131	broad.mit.edu	37	chr19	7964521	7964521	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcatgctgcacctcatcgatCagtacgactccctctactcc	5	17	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:7964521C>T	uc002mir.2	+	3	1215	c.1114C>T	c.(1114-1116)CAG>TAG	p.Q372*		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	372						integral to membrane				lung(1)|pancreas(1)	2						CCTCATCGATCAGTACGACTC	0.572													0	0	0	0.010504	0	17	49										T	7964521	C	T	7964521	4	4	117	1	0	0	0	0	0	1	0	0	9025	827	29	1	1120	1	LRRC8E	19	7964521	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6603998	7964521	51164462	475	35465										
TIMM44	10469	broad.mit.edu	37	chr19	7992542	7992542	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catcccactccctcactcacCgggtcaccctccaccacctc	3	24	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:7992542C>T	uc002miz.2	-	12	1241	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	TIMM44_uc002mja.2_Silent_p.P153P|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	413					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CCTCACTCACCGGGTCACCCT	0.627													0	0	0	0.00361	0	106	88										T	7992542	C	T	7992542	2	4	117	1	0	0	0	0	0	0	0	1	15909	666	23	2		2	TIMM44	19	7992542	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	28021	7992542	51136441	476	35466										
DNM2	1785	broad.mit.edu	37	chr19	10934516	10934516	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggcctgtgactcccaggaaGacgtggacagctggaaggcc	15	11	0	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:10934516G>A	uc002mps.1	+	17	1998	c.1834G>A	c.(1834-1836)GAC>AAC	p.D612N	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.D612N|DNM2_uc002mpv.1_Missense_Mutation_p.D608N|DNM2_uc002mpu.1_Missense_Mutation_p.D608N|DNM2_uc010dxl.1_Missense_Mutation_p.D612N|DNM2_uc002mpw.2_Missense_Mutation_p.D341N|DNM2_uc002mpx.1_5'UTR	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	612	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCCCAGGAAGACGTGGACAG	0.667													0	0	0	0.00361	0	39	52										A	10934516	G	A	10934516	3	1	117	1	0	0	0	0	1	0	0	0	4672	942	33	1	2043	1	DNM2	19	10934516	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2941974	10934516	48194467	477	35467										
DNM2	1785	broad.mit.edu	37	chr19	10934530	10934530	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caggaagacgtggacagctgGaaggcctcgttcctccgagc	14	12	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:10934530G>C	uc002mps.1	+	17	2012	c.1848G>C	c.(1846-1848)TGG>TGC	p.W616C	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.W616C|DNM2_uc002mpv.1_Missense_Mutation_p.W612C|DNM2_uc002mpu.1_Missense_Mutation_p.W612C|DNM2_uc010dxl.1_Missense_Mutation_p.W616C|DNM2_uc002mpw.2_Missense_Mutation_p.W345C|DNM2_uc002mpx.1_5'UTR	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	616	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TGGACAGCTGGAAGGCCTCGT	0.657													0	0	0	0.00361	0	30	49										C	10934530	G	C	10934530	3	2	117	1	0	0	0	0	1	0	0	0	4672	1183	41	1	2057	1	DNM2	19	10934530	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	14	10934530	48194453	478	35468										
ZNF442	79973	broad.mit.edu	37	chr19	12474396	12474396	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttctctcttcattagtctgaGagtcaggaaggaagagatca	10	7	6	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:12474396G>C	uc002mtr.1	-	3	661	c.50C>G	c.(49-51)TCT>TGT	p.S17C	ZNF442_uc010xmk.1_Intron	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						ATTAGTCTGAGAGTCAGGAAG	0.488													0	0	0	0.004482	0	8	140										C	12474396	G	C	12474396	3	2	117	1	0	0	0	0	1	0	0	0	17912	942	33	1	1849	1	ZNF442	19	12474396	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1539866	12474396	46654587	479	35469										
MAN2B1	4125	broad.mit.edu	37	chr19	12767436	12767436	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttcacaacgaaaacgccttcGctgaccggcagccgtaccat	8	15	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:12767436G>A	uc002mub.2	-	13	1669	c.1593C>T	c.(1591-1593)AGC>AGT	p.S531S	MAN2B1_uc010dyv.1_Silent_p.S530S	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	531					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						AAACGCCTTCGCTGACCGGCA	0.602													0	0	0	0.00361	0	106	68										A	12767436	G	A	12767436	2	1	117	1	0	0	0	0	0	0	0	1	9216	1078	38	2		2	MAN2B1	19	12767436	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	293040	12767436	46361547	480	35470										
CASP14	23581	broad.mit.edu	37	chr19	15164702	15164702	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gagaatctcttcgaggccctGaacaacaagaactgccaggc	10	12	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:15164702G>T	uc010dzv.1	+	4	644	c.336G>T	c.(334-336)CTG>CTT	p.L112L	CASP14_uc002naf.2_Silent_p.L112L	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor	112					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						TCGAGGCCCTGAACAACAAGA	0.562													1	0	3.11337e-16	0.002836	3.31456e-16	29	48										T	15164702	G	T	15164702	2	4	117	1	0	0	0	0	0	0	0	1	2670	1277	45	3		3	CASP14	19	15164702	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2397266	15164702	43964281	481	35471										
CHERP	10523	broad.mit.edu	37	chr19	16652774	16652774	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggggttgtccttctgcttctCcatagtcatcttctcaaact	7	12	5	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:16652774C>G	uc002nei.1	-	2	180	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	MED26_uc002nee.2_Intron|CHERP_uc002nej.2_Missense_Mutation_p.E4Q	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	36	SURP motif.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						TTCTGCTTCTCCATAGTCATC	0.532													0	0	0	0.00278	0	21	40										G	16652774	C	G	16652774	3	3	117	1	0	0	0	0	1	0	0	0	3336	864	30	1	2708	1	CHERP	19	16652774	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1488072	16652774	42476209	482	35472										
CHERP	10523	broad.mit.edu	37	chr19	16653168	16653168	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccggtttgggtctcaccatCggggggcagcggcatctcca	15	13	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:16653168C>G	uc002nei.1	-	1	96	c.22G>C	c.(22-24)GAT>CAT	p.D8H	MED26_uc002nee.2_Intron|CHERP_uc002nej.2_5'Flank	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	8					cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						GTCTCACCATCGGGGGGCAGC	0.726													0	0	0	0.004482	0	3	14										G	16653168	C	G	16653168	3	3	117	1	0	0	0	0	1	0	0	0	3336	884	31	1	2796	1	CHERP	19	16653168	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	394	16653168	42475815	483	35473										
MAP1S	55201	broad.mit.edu	37	chr19	17831750	17831750	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctccttcccaccaggcatcCggtcttgggatgtcgatcct	9	16	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:17831750C>T	uc002nhe.1	+	2	133	c.124C>T	c.(124-126)CGG>TGG	p.R42W	MAP1S_uc010eaz.1_Intron|MAP1S_uc010eba.1_Missense_Mutation_p.R42W|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Missense_Mutation_p.R16W	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	42	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						ACCAGGCATCCGGTCTTGGGA	0.582													0	0	0	0.010729	0	8	128										T	17831750	C	T	17831750	3	4	117	1	0	0	0	0	1	0	0	0	9234	643	23	2	130	2	MAP1S	19	17831750	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1178582	17831750	41297233	484	35474										
ZNF253	56242	broad.mit.edu	37	chr19	19990934	19990934	+	Missense_Mutation	SNP	G	G	A													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctttaactatggaaagacatGagatgattgccaaaccccca							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:19990934G>A	uc002noj.2	+	3	297	c.205G>A	c.(205-207)GAG>AAG	p.E69K	ZNF253_uc002nok.2_Intron|ZNF253_uc002nol.2_Intron	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	69	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAAAGACATGAGATGATTGC	0.373													0	0	0	0.001984	0	7	33										A	19990934	G	A	19990934	3	1	117	1	0	0	0	0	1	0	0	0	17794	1291	45	1	215	1	ZNF253	19	19990934	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2159184	19990934	39138049	485	35475	185	2								
ZNF253	56242	broad.mit.edu	37	chr19	19990939	19990939	+	Missense_Mutation	SNP	G	G	A													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	actatggaaagacatgagatGattgccaaacccccaggtag							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:19990939G>A	uc002noj.2	+	3	302	c.210G>A	c.(208-210)ATG>ATA	p.M70I	ZNF253_uc002nok.2_Intron|ZNF253_uc002nol.2_Intron	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	70	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACATGAGATGATTGCCAAAC	0.373													0	0	0	0.001168	0	6	33										A	19990939	G	A	19990939	3	1	117	1	0	0	0	0	1	0	0	0	17794	1290	45	1	220	1	ZNF253	19	19990939	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	5	19990939	39138044	486	35476	185	2								
ZNF493	284443	broad.mit.edu	37	chr19	21606279	21606279	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atgtgaagaatgtggcacatCtttctaccaattctcatacc	6	10	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21606279C>T	uc002npx.2	+	2	714	c.434C>T	c.(433-435)TCT>TTT	p.S145F	ZNF493_uc002npw.2_Missense_Mutation_p.S273F|ZNF493_uc002npy.2_Missense_Mutation_p.S145F	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	145	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGGCACATCTTTCTACCAA	0.348													0	0	0	0.00499	0	16	3										T	21606279	C	T	21606279	3	4	117	1	0	0	0	0	1	0	0	0	17941	913	32	1	895	1	ZNF493	19	21606279	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1615340	21606279	37522704	487	35477			4	168		4	4	1482	C		3.035891e-06
ZNF493	284443	broad.mit.edu	37	chr19	21607244	21607244	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttactaaacacaagataattCatactgataagaaaccctac	3	9	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21607244C>T	uc002npx.2	+	2	1679	c.1399C>T	c.(1399-1401)CAT>TAT	p.H467Y	ZNF493_uc002npw.2_Missense_Mutation_p.H595Y|ZNF493_uc002npy.2_Missense_Mutation_p.H467Y	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	467	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAAGATAATTCATACTGATAA	0.333													0	0	0	0.00308	0	7	1										T	21607244	C	T	21607244	3	4	117	1	0	0	0	0	1	0	0	0	17941	826	29	1	1860	1	ZNF493	19	21607244	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	965	21607244	37521739	488	35478			4	168		4	4	1482	C		3.035891e-06
ZNF493	284443	broad.mit.edu	37	chr19	21607722	21607722	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caaagcttttaggcggtcttCacatcttagtagacataaga	8	8	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21607722C>T	uc002npx.2	+	2	2157	c.1877C>T	c.(1876-1878)TCA>TTA	p.S626L	ZNF493_uc002npw.2_Missense_Mutation_p.S754L|ZNF493_uc002npy.2_Missense_Mutation_p.S626L	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	626	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGCGGTCTTCACATCTTAGT	0.373													0	0	0	0.004482	0	9	4										T	21607722	C	T	21607722	3	4	117	1	0	0	0	0	1	0	0	0	17941	838	29	1	2338	1	ZNF493	19	21607722	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	478	21607722	37521261	489	35479			4	168		4	4	1482	C		3.035891e-06
ZNF493	284443	broad.mit.edu	37	chr19	21607760	21607760	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agataattcatattggaattCatactgaagagactgtacaa	7	5	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:21607760C>T	uc002npx.2	+	2	2195	c.1915C>T	c.(1915-1917)CAT>TAT	p.H639Y	ZNF493_uc002npw.2_Missense_Mutation_p.H767Y|ZNF493_uc002npy.2_Missense_Mutation_p.H639Y	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	639					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TATTGGAATTCATACTGAAGA	0.378													0	0	0	0.00245	0	12	6										T	21607760	C	T	21607760	3	4	117	1	0	0	0	0	1	0	0	0	17941	826	29	1	2376	1	ZNF493	19	21607760	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	38	21607760	37521223	490	35480			4	168		4	4	1482	C		3.035891e-06
ZNF91	7644	broad.mit.edu	37	chr19	23544994	23544994	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttcacacttgtagattttctCtttagcacagattattttat	4	7	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:23544994C>G	uc002nre.2	-	4	900	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	ZNF91_uc010xrj.1_Missense_Mutation_p.E231Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	263						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TAGATTTTCTCTTTAGCACAG	0.378													0	0	0	0.002836	0	29	42										G	23544994	C	G	23544994	3	3	117	1	0	0	0	0	1	0	0	0	18197	922	32	1	2792	1	ZNF91	19	23544994	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1937234	23544994	35583989	491	35481										
ZNF536	9745	broad.mit.edu	37	chr19	30934886	30934886	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccactctgcggcaagcgcttCcgcttcaacagcatcctctc	7	18	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:30934886C>T	uc002nsu.1	+	2	555	c.417C>T	c.(415-417)TTC>TTT	p.F139F	ZNF536_uc010edd.1_Silent_p.F139F	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	139	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.F139F(1)		ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCAAGCGCTTCCGCTTCAACA	0.637													0	0	0	0.00361	0	207	50										T	30934886	C	T	30934886	2	4	117	1	0	0	0	0	0	0	0	1	17971	854	30	1		1	ZNF536	19	30934886	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	7389892	30934886	28194097	492	35482										
GPI	2821	broad.mit.edu	37	chr19	34884965	34884965	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caccgctttgctgcgtacttCcagcaggtaccagctgccaa	9	15	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:34884965C>T	uc002nvg.1	+	12	1159	c.1056C>T	c.(1054-1056)TTC>TTT	p.F352F	GPI_uc002nvf.2_Silent_p.F391F|GPI_uc010xrv.1_Silent_p.F363F|GPI_uc010xrw.1_Silent_p.F324F|GPI_uc010edl.1_Silent_p.F352F|GPI_uc002nvi.1_Silent_p.F15F	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	352					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					CTGCGTACTTCCAGCAGGTAC	0.577													0	0	0	0.00361	0	42	50										T	34884965	C	T	34884965	2	4	117	1	0	0	0	0	0	0	0	1	6611	854	30	1		1	GPI	19	34884965	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3950079	34884965	24244018	493	35483										
ZNF585B	92285	broad.mit.edu	37	chr19	37676214	37676214	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacacttgtagggtttgtctCcagtgtgtgttgtctgatgt	12	7	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:37676214C>G	uc002ofq.2	-	5	2479	c.2225G>C	c.(2224-2226)GGA>GCA	p.G742A	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.G556A	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	742					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGGTTTGTCTCCAGTGTGTGT	0.478													0	0	0	0.001368	0	10	203										G	37676214	C	G	37676214	3	3	117	1	0	0	0	0	1	0	0	0	18015	855	30	1	88	1	ZNF585B	19	37676214	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2791249	37676214	21452769	494	35484										
SIPA1L3	23094	broad.mit.edu	37	chr19	38633219	38633219	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgtctccttctaggcctgtCagcttcccagaaacccctta	6	16	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:38633219C>T	uc002ohk.2	+	12	3911	c.3402C>T	c.(3400-3402)GTC>GTT	p.V1134V		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1134					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTAGGCCTGTCAGCTTCCCAG	0.542											OREG0025445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	337	316										T	38633219	C	T	38633219	2	4	117	1	0	0	0	0	0	0	0	1	14331	813	29	1		1	SIPA1L3	19	38633219	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	957005	38633219	20495764	495	35485										
RYR1	6261	broad.mit.edu	37	chr19	39055650	39055650	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	acgtggtgaacgagggcggcGaggctgagaagatggagctc	19	7	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:39055650G>A	uc002oit.2	+	91	12806	c.12676G>A	c.(12676-12678)GAG>AAG	p.E4226K	RYR1_uc002oiu.2_Missense_Mutation_p.E4221K|RYR1_uc002oiv.1_Missense_Mutation_p.E1135K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4226					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGAGGGCGGCGAGGCTGAGAA	0.642													0	0	0	0.003163	0	11	20										A	39055650	G	A	39055650	3	1	117	1	0	0	0	0	1	0	0	0	13768	1059	37	1	13038	1	RYR1	19	39055650	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	422431	39055650	20073333	496	35486										
ZFP36	7538	broad.mit.edu	37	chr19	39898948	39898950	+	In_Frame_Del	DEL	CAC	CAC	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gccctctggccgccggacctCaccaccaccaccaggcctgg							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:39898948_39898950delCAC	uc002olh.1	+	2	648_650	c.590_592delCAC	c.(589-594)TCACCA>TCA	p.P201del	ZFP36_uc010egn.1_In_Frame_Del_p.H73del	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog	201	P-P-P-P-G.				positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGCCGGACCTCACCACCACCACC	0.685																		8	725	---	---								-	39898950	CAC	-	39898948	7	5	117	1	0	1	0	1	0	0	0	0	17642	838	29	0	596	0	ZFP36	19	39898948	In_Frame_Del	DEL	CAC	TCGA-GV-A3JZ-01A-11D-A21A-08	843298	39898948	19230035	497	35487										
ZNF780A	284323	broad.mit.edu	37	chr19	40580582	40580582	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agtcgaaaggctttcccacaCtccttacattcaaagggttt	7	11	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:40580582C>T	uc002omy.2	-	6	1992	c.1767G>A	c.(1765-1767)GAG>GAA	p.E589E	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Silent_p.E589E|ZNF780A_uc010xvh.1_Silent_p.E590E	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	589	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTTTCCCACACTCCTTACATT	0.393													0	0	0	0.000602	0	4	251										T	40580582	C	T	40580582	2	4	117	1	0	0	0	0	0	0	0	1	18149	564	20	2		2	ZNF780A	19	40580582	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	681634	40580582	18548401	498	35488										
CYP2A6	1548	broad.mit.edu	37	chr19	41351241	41351241	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aacttggtgtcctttttgacTctgcgggccaaactcatggg	11	10	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:41351241T>C	uc002opl.3	-	7	1140	c.1119A>G	c.(1117-1119)AGA>AGG	p.R373R	CYP2A6_uc010ehe.1_Silent_p.R169R	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	373					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CCTTTTTGACTCTGCGGGCCA	0.572													0	0	0	0.008291	0	5	270										C	41351241	T	C	41351241	2	2	117	1	0	0	0	0	0	0	0	1	4162	1548	54	5		5	CYP2A6	19	41351241	Silent	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	770659	41351241	17777742	499	35489										
CIC	23152	broad.mit.edu	37	chr19	42796294	42796294	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcggcctggtgccgcccctGagcccagccacactccctgg	12	19	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:42796294G>C	uc002otf.1	+	12	2983	c.2943G>C	c.(2941-2943)CTG>CTC	p.L981L		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	981	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				TGCCGCCCCTGAGCCCAGCCA	0.652			T	DUX4	soft tissue sarcoma								0	0	0	0.00361	0	80	64										C	42796294	G	C	42796294	2	2	117	1	0	0	0	0	0	0	0	1	3424	1277	45	1		1	CIC	19	42796294	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1445053	42796294	16332689	500	35490										
ZNF230	7773	broad.mit.edu	37	chr19	44514657	44514657	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcagtgatgttgccatctttGatcctcctcagcagttccac	7	13	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:44514657G>C	uc002oyb.1	+	5	717	c.466G>C	c.(466-468)GAT>CAT	p.D156H		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	156	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGCCATCTTTGATCCTCCTCA	0.453													0	0	0	0.00361	0	79	117										C	44514657	G	C	44514657	3	2	117	1	0	0	0	0	1	0	0	0	17781	1290	45	1	480	1	ZNF230	19	44514657	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1718363	44514657	14614326	501	35491										
ZNF223	7766	broad.mit.edu	37	chr19	44571265	44571265	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cattgccgaaaaaaaccattCaaatgtgaggattgtggaaa	9	6	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:44571265C>G	uc002oyf.1	+	5	1537	c.1284C>G	c.(1282-1284)TTC>TTG	p.F428L	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	428	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				AAAAACCATTCAAATGTGAGG	0.408													0	0	0	0.00361	0	60	66										G	44571265	C	G	44571265	3	3	117	1	0	0	0	0	1	0	0	0	17774	825	29	1	1298	1	ZNF223	19	44571265	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	56608	44571265	14557718	502	35492										
CEACAM19	56971	broad.mit.edu	37	chr19	45175238	45175238	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggggacccagggctgcttctCaaagagcctcctgctctcag	12	14	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:45175238C>T	uc002ozo.3	+	1	515	c.35C>T	c.(34-36)TCA>TTA	p.S12L	CEACAM19_uc002ozp.3_Missense_Mutation_p.S12L	NM_020219	NP_064604	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion	12						integral to membrane					0	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				GGCTGCTTCTCAAAGAGCCTC	0.562													0	0	0	0.00499	0	12	17										T	45175238	C	T	45175238	3	4	117	1	0	0	0	0	1	0	0	0	3190	838	29	1	37	1	CEACAM19	19	45175238	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	603973	45175238	13953745	503	35493										
GIPR	2696	broad.mit.edu	37	chr19	46178078	46178078	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaccaggcccttgcgctgtgGaaccaggtgggcatcctcct	13	14	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:46178078G>A	uc002pcu.1	+	7	726	c.627G>A	c.(625-627)TGG>TGA	p.W209*	GIPR_uc002pct.1_Nonsense_Mutation_p.W209*|GIPR_uc010xxp.1_Nonsense_Mutation_p.W173*|GIPR_uc010xxq.1_RNA|MIR642_hsa-mir-642|MI0003657_5'Flank	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	209	Extracellular (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		TTGCGCTGTGGAACCAGGTGG	0.577													0	0	0	0.004656	0	20	61										A	46178078	G	A	46178078	4	1	117	1	0	0	0	0	0	1	0	0	6395	1183	41	1	649	1	GIPR	19	46178078	Nonsense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1002840	46178078	12950905	504	35494										
TULP2	7288	broad.mit.edu	37	chr19	49392787	49392787	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttttggaaggccaagttttCatatacacagtcaccatcca	6	11	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:49392787C>T	uc002pkz.2	-	7	767	c.616G>A	c.(616-618)GAA>AAA	p.E206K		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	206					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GCCAAGTTTTCATATACACAG	0.502													0	0	0	0.00361	0	65	135										T	49392787	C	T	49392787	3	4	117	1	0	0	0	0	1	0	0	0	16771	835	29	1	974	1	TULP2	19	49392787	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3214709	49392787	9736196	505	35495										
ZNF766	90321	broad.mit.edu	37	chr19	52785369	52785369	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catcttttattttagggacaCttgacattcagggacgtggc	10	8	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:52785369C>T	uc002pyr.1	+	2	67	c.24C>T	c.(22-24)CAC>CAT	p.H8H	ZNF766_uc002pys.1_Silent_p.H8H|ZNF766_uc002pyt.1_Silent_p.H23H	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		TTTAGGGACACTTGACATTCA	0.438													0	0	0	0.00361	0	147	163										T	52785369	C	T	52785369	2	4	117	1	0	0	0	0	0	0	0	1	18137	564	20	2		2	ZNF766	19	52785369	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3392582	52785369	6343614	506	35496										
ZNF480	147657	broad.mit.edu	37	chr19	52824897	52824897	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aaaaacaacttggagtatccTttcacttacatctgtctgaa	5	9	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:52824897T>A	uc010ydl.1	+	5	464	c.394T>A	c.(394-396)TTT>ATT	p.F132I	ZNF480_uc002pyv.2_Missense_Mutation_p.F55I|ZNF480_uc010ydm.1_Missense_Mutation_p.F89I|ZNF480_uc010epn.2_5'UTR|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		TGGAGTATCCTTTCACTTACA	0.378													0	0	0	0.006122	0	14	78										A	52824897	T	A	52824897	3	1	117	1	0	0	0	0	1	0	0	0	17932	1609	56	5	408	5	ZNF480	19	52824897	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	39528	52824897	6304086	507	35497										
ZNF761	388561	broad.mit.edu	37	chr19	53959484	53959484	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	atcgtagacttcatagtggaGagaacccttacaaatgtgaa	9	7	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:53959484G>C	uc010eqp.2	+	7	2181	c.1723G>C	c.(1723-1725)GAG>CAG	p.E575Q	ZNF761_uc010ydy.1_Missense_Mutation_p.E521Q|ZNF761_uc002qbt.1_Missense_Mutation_p.E521Q	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TCATAGTGGAGAGAACCCTTA	0.383													0	0	0	0.010729	0	11	91										C	53959484	G	C	53959484	3	2	117	1	0	0	0	0	1	0	0	0	18133	943	33	1	1734	1	ZNF761	19	53959484	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1134587	53959484	5169499	508	35498										
USP29	57663	broad.mit.edu	37	chr19	57642777	57642777	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caggggtgatccctcaggggGaatacgaaggtgactctttg	15	8	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:57642777G>A	uc002qny.2	+	4	3090	c.2734G>A	c.(2734-2736)GAA>AAA	p.E912K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	912					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCTCAGGGGGAATACGAAGG	0.468													0	0	0	0.00361	0	76	92										A	57642777	G	A	57642777	3	1	117	1	0	0	0	0	1	0	0	0	17056	1175	41	1	2736	1	USP29	19	57642777	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3683293	57642777	1486206	509	35499										
ZNF544	27300	broad.mit.edu	37	chr19	58772798	58772799	+	Missense_Mutation	DNP	GG	GG	AT													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgatgactgtaaggattatGgaaacctcttcagtcacagt							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr19:58772798_58772799GG>AT	uc010euo.2	+	7	1300_1301	c.826_827GG>AT	c.(826-828)GGA>ATA	p.G276I	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.G248I|ZNF544_uc010yhy.1_Missense_Mutation_p.G248I|ZNF544_uc002qrt.3_Missense_Mutation_p.G134I|ZNF544_uc002qru.3_Missense_Mutation_p.G134I|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TAAGGATTATGGAAACCTCTTC	0.411													0	0	0	0.004672	0	13	82										AT	58772799	GG	AT	58772798	3	1	117	1	0	0	0	0	1	0	0	0	17974	1349	47	2	840	2	ZNF544	19	58772798	Missense_Mutation	DNP	GG	TCGA-GV-A3JZ-01A-11D-A21A-08	1130021	58772798	356185	510	35500										
IDH3B	3420	broad.mit.edu	37	chr20	2639436	2639436	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggtgaccgatgacagacttGatgaagtcggttgtggtgct	15	6	0	5	rs140692628		TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:2639436G>C	uc002wgp.2	-	12	1128	c.1119C>G	c.(1117-1119)ATC>ATG	p.I373M	IDH3B_uc002wgq.2_Intron|IDH3B_uc002wgr.2_Missense_Mutation_p.I221M	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	373					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	TGACAGACTTGATGAAGTCGG	0.552													0	0	0	0.00874	0	31	45										C	2639436	G	C	2639436	3	2	117	1	0	0	0	0	1	0	0	0	7497	1280	45	1	127	1	IDH3B	20	2639436	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		2639436	60386084	511	35501										
IDH3B	3420	broad.mit.edu	37	chr20	2640753	2640753	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccaaccaggccagcagccaGattgtcaataatgttcccat	7	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:2640753G>C	uc002wgp.2	-	9	847	c.838C>G	c.(838-840)CTG>GTG	p.L280V	IDH3B_uc002wgq.2_Missense_Mutation_p.L280V|IDH3B_uc002wgr.2_Missense_Mutation_p.L128V	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	280					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)	CCAGCAGCCAGATTGTCAATA	0.517													0	0	0	0.009718	0	38	55										C	2640753	G	C	2640753	3	2	117	1	0	0	0	0	1	0	0	0	7497	933	33	1	420	1	IDH3B	20	2640753	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1317	2640753	60384767	512	35502										
SEC23B	10483	broad.mit.edu	37	chr20	18535017	18535017	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgccacgttacatcaacacgGagcatggaggcagtcaggtg	13	10	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:18535017G>A	uc002wqz.1	+	18	2574	c.2131G>A	c.(2131-2133)GAG>AAG	p.E711K	SEC23B_uc002wra.1_Missense_Mutation_p.E711K|SEC23B_uc002wrb.1_Missense_Mutation_p.E711K|SEC23B_uc010zsb.1_Missense_Mutation_p.E693K|SEC23B_uc002wrc.1_Missense_Mutation_p.E711K	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	711					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CATCAACACGGAGCATGGAGG	0.458													0	0	0	0.00361	0	78	63										A	18535017	G	A	18535017	3	1	117	1	0	0	0	0	1	0	0	0	13992	1175	41	1	2197	1	SEC23B	20	18535017	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	15894264	18535017	44490503	513	35503										
C20orf26	26074	broad.mit.edu	37	chr20	20177385	20177385	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	taggctttaaatcctgtctcTactaccgtgtttacccaaaa	5	11	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:20177385T>G	uc002wru.2	+	16	1838	c.1762T>G	c.(1762-1764)TAC>GAC	p.Y588D	C20orf26_uc010zse.1_Missense_Mutation_p.Y568D	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	588										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ATCCTGTCTCTACTACCGTGT	0.473													0	0	0	0.010504	0	18	56										G	20177385	T	G	20177385	3	3	117	1	0	0	0	0	1	0	0	0	2106	1522	53	5	1852	5	C20orf26	20	20177385	Missense_Mutation	SNP	T	TCGA-GV-A3JZ-01A-11D-A21A-08	1642368	20177385	42848135	514	35504										
C20orf26	26074	broad.mit.edu	37	chr20	20257987	20257987	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggacgcgctaggagccgccgGagtcactatgtaccgggatg	16	11	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:20257987G>C	uc002wru.2	+	22	2757	c.2681G>C	c.(2680-2682)GGA>GCA	p.G894A	C20orf26_uc010zse.1_Missense_Mutation_p.G874A|C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	894										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GGAGCCGCCGGAGTCACTATG	0.652													0	0	0	0.007291	0	28	58										C	20257987	G	C	20257987	3	2	117	1	0	0	0	0	1	0	0	0	2106	1174	41	1	2795	1	C20orf26	20	20257987	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	80602	20257987	42767533	515	35505										
ENTPD6	955	broad.mit.edu	37	chr20	25203528	25203528	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtcagaggtccttcaaaacaGagtgcacaggacggaggaag	14	8	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:25203528G>C	uc002wuj.2	+	12	1280	c.1100G>C	c.(1099-1101)AGA>ACA	p.R367T	ENTPD6_uc010zsz.1_Missense_Mutation_p.R149T|ENTPD6_uc002wum.2_Missense_Mutation_p.R350T|ENTPD6_uc010zta.1_Missense_Mutation_p.R367T|ENTPD6_uc002wun.2_Missense_Mutation_p.R333T|ENTPD6_uc002wuk.2_Missense_Mutation_p.R366T|ENTPD6_uc002wul.2_Missense_Mutation_p.R366T|ENTPD6_uc010ztb.1_Missense_Mutation_p.R339T|ENTPD6_uc010ztc.1_Missense_Mutation_p.R339T|ENTPD6_uc002wuo.2_Missense_Mutation_p.R119T|ENTPD6_uc010ztd.1_Missense_Mutation_p.R115T|ENTPD6_uc010gdk.1_RNA|ENTPD6_uc010gdl.1_RNA	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	367	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						CTTCAAAACAGAGTGCACAGG	0.582													0	0	0	0.00361	0	116	65										C	25203528	G	C	25203528	3	2	117	1	0	0	0	0	1	0	0	0	5143	942	33	1	1149	1	ENTPD6	20	25203528	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	4945541	25203528	37821992	516	35506										
NINL	22981	broad.mit.edu	37	chr20	25459797	25459797	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	catgtccttcctctccttctCaaagttccttttcagtgccg	5	15	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:25459797C>T	uc002wux.1	-	16	2037	c.1963G>A	c.(1963-1965)GAG>AAG	p.E655K	NINL_uc010gdn.1_Missense_Mutation_p.E655K|NINL_uc010gdo.1_Missense_Mutation_p.E438K	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	655	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						CTCTCCTTCTCAAAGTTCCTT	0.537													0	0	0	0.00333	0	19	71										T	25459797	C	T	25459797	3	4	117	1	0	0	0	0	1	0	0	0	10420	835	29	1	2221	1	NINL	20	25459797	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	256269	25459797	37565723	517	35507										
CBFA2T2	9139	broad.mit.edu	37	chr20	32210977	32210977	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcgctcgggcggccaagcaGaccccatcccagtacctggc	12	17	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:32210977G>C	uc002wzg.1	+	6	1131	c.594G>C	c.(592-594)CAG>CAC	p.Q198H	CBFA2T2_uc010zug.1_5'UTR|CBFA2T2_uc002wze.1_Missense_Mutation_p.Q189H|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.Q169H|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	198	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						CGGCCAAGCAGACCCCATCCC	0.582													0	0	0	0.004289	0	32	129										C	32210977	G	C	32210977	3	2	117	1	0	0	0	0	1	0	0	0	2697	933	33	1	650	1	CBFA2T2	20	32210977	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6751180	32210977	30814543	518	35508										
NCOA6	23054	broad.mit.edu	37	chr20	33364229	33364229	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ctgttccagggctccaccttCtgtacttttagcttgctgga	9	12	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:33364229C>T	uc002xav.2	-	5	2829	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	NCOA6_uc002xaw.2_Silent_p.Q86Q|NCOA6_uc010gew.1_Silent_p.Q86Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	86	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GCTCCACCTTCTGTACTTTTA	0.453													0	0	0	0.00278	0	19	51										T	33364229	C	T	33364229	2	4	117	1	0	0	0	0	0	0	0	1	10233	912	32	1		1	NCOA6	20	33364229	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1153252	33364229	29661291	519	35509										
UQCC	55245	broad.mit.edu	37	chr20	33891825	33891825	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agagggcgccagctcacctcCcctgtcagaagcagatcctc	10	16	2	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:33891825C>T	uc002xcd.2	-	10	880	c.813G>A	c.(811-813)GGG>GGA	p.G271G	UQCC_uc010zuy.1_Silent_p.G172G|UQCC_uc010zuz.1_Silent_p.G116G|UQCC_uc010zva.1_Silent_p.G134G|UQCC_uc002xce.2_Silent_p.G244G|UQCC_uc002xcg.2_Silent_p.G137G|UQCC_uc010gfb.2_Silent_p.G245G|UQCC_uc010zvb.1_Silent_p.G203G|UQCC_uc002xcf.2_Silent_p.G159G|UQCC_uc002xch.2_RNA|UQCC_uc002xcc.2_Silent_p.G84G	NM_018244	NP_060714	Q9NVA1	UQCC_HUMAN	basic FGF-repressed Zic binding protein isoform	271						cytoplasmic membrane-bounded vesicle				breast(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			AGCTCACCTCCCCTGTCAGAA	0.592											OREG0025888	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	71	53										T	33891825	C	T	33891825	2	4	117	1	0	0	0	0	0	0	0	1	17012	610	22	2		2	UQCC	20	33891825	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	527596	33891825	29133695	520	35510										
CHD6	84181	broad.mit.edu	37	chr20	40127937	40127937	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaaacatgagccaccaacctCctggacagtcttagatgcca	8	13	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:40127937C>T	uc002xka.1	-	6	1091	c.913G>A	c.(913-915)GAG>AAG	p.E305K	CHD6_uc002xkd.2_Missense_Mutation_p.E283K|CHD6_uc002xkc.2_Missense_Mutation_p.E340K	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	305	Chromo 1.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CCACCAACCTCCTGGACAGTC	0.403													0	0	0	0.006122	0	13	5										T	40127937	C	T	40127937	3	4	117	1	0	0	0	0	1	0	0	0	3329	864	30	1	7362	1	CHD6	20	40127937	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	6236112	40127937	22897583	521	35511										
TOX2	84969	broad.mit.edu	37	chr20	42694696	42694696	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccctgtcctgcccaccccCatggcactccaggtgcagct	8	21	0	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:42694696C>A	uc002xlf.3	+	6	1268	c.1251C>A	c.(1249-1251)CCC>CCA	p.P417P	TOX2_uc010ggo.2_Silent_p.P435P|TOX2_uc002xle.3_Silent_p.P393P|TOX2_uc010ggp.2_Silent_p.P393P|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Silent_p.P313P	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	417	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGCCCACCCCCATGGCACTCC	0.677													1	0	2.47907e-22	0.00361	2.6826e-22	48	25										A	42694696	C	A	42694696	2	1	117	1	0	0	0	0	0	0	0	1	16375	581	21	4		4	TOX2	20	42694696	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2566759	42694696	20330824	522	35512										
ZMYND8	23613	broad.mit.edu	37	chr20	45875047	45875047	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttttcagctcctctttaatCtccactgggtttgtaggctt	7	11	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:45875047C>G	uc002xta.1	-	14	2183	c.1929G>C	c.(1927-1929)GAG>GAC	p.E643D	ZMYND8_uc010ghq.1_Missense_Mutation_p.E320D|ZMYND8_uc010ghr.1_Missense_Mutation_p.E618D|ZMYND8_uc002xst.1_Missense_Mutation_p.E571D|ZMYND8_uc002xsu.1_Missense_Mutation_p.E643D|ZMYND8_uc002xsv.1_Missense_Mutation_p.E571D|ZMYND8_uc002xsw.1_Missense_Mutation_p.E395D|ZMYND8_uc002xsx.1_Missense_Mutation_p.E395D|ZMYND8_uc002xsy.1_Missense_Mutation_p.E618D|ZMYND8_uc002xsz.1_Missense_Mutation_p.E580D|ZMYND8_uc010zxy.1_Missense_Mutation_p.E670D|ZMYND8_uc002xtb.1_Missense_Mutation_p.E663D|ZMYND8_uc002xss.2_Missense_Mutation_p.E643D|ZMYND8_uc010zxz.1_Missense_Mutation_p.E638D|ZMYND8_uc002xtc.1_Missense_Mutation_p.E663D|ZMYND8_uc002xtd.1_Missense_Mutation_p.E638D|ZMYND8_uc002xte.1_Missense_Mutation_p.E643D|ZMYND8_uc010zya.1_Missense_Mutation_p.E643D|ZMYND8_uc002xtf.1_Missense_Mutation_p.E663D|ZMYND8_uc002xtg.2_Missense_Mutation_p.E637D|ZMYND8_uc010ghs.1_Missense_Mutation_p.E637D	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	643							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CCTCTTTAATCTCCACTGGGT	0.512													0	0	0	0.00361	0	42	158										G	45875047	C	G	45875047	3	3	117	1	0	0	0	0	1	0	0	0	17708	912	32	1	1617	1	ZMYND8	20	45875047	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3180351	45875047	17150473	523	35513										
PARD6B	84612	broad.mit.edu	37	chr20	49354553	49354553	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tactacctataaataatgatGataattatcacaaagctgtt	4	6	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:49354553G>A	uc002xvo.2	+	2	469	c.226G>A	c.(226-228)GAT>AAT	p.D76N		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	76	OPR.				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1						AAATAATGATGATAATTATCA	0.338													0	0	0	0.00361	0	41	22										A	49354553	G	A	49354553	3	1	117	1	0	0	0	0	1	0	0	0	11446	1290	45	1	232	1	PARD6B	20	49354553	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3479506	49354553	13670967	524	35514										
ZNF831	128611	broad.mit.edu	37	chr20	57768706	57768706	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agagtgccaggcaggtgggcGagcctctggagtcctctgga	17	10	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:57768706G>A	uc002yan.2	+	1	2632	c.2632G>A	c.(2632-2634)GAG>AAG	p.E878K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	878						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCAGGTGGGCGAGCCTCTGGA	0.657													0	0	0	0.007413	0	14	86										A	57768706	G	A	57768706	3	1	117	1	0	0	0	0	1	0	0	0	18182	1059	37	1	2634	1	ZNF831	20	57768706	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8414153	57768706	5256814	525	35515										
CDH4	1002	broad.mit.edu	37	chr20	60509192	60509192	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cccctggcgtgcgtcgcgtgGatgagcggccggtgggcgct	19	13	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:60509192G>C	uc002ybn.1	+	15	2472	c.2458G>C	c.(2458-2460)GAT>CAT	p.D820H	CDH4_uc002ybp.1_Missense_Mutation_p.D746H	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	820	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCGTCGCGTGGATGAGCGGCC	0.677													0	0	0	0.004007	0	11	74										C	60509192	G	C	60509192	3	2	117	1	0	0	0	0	1	0	0	0	3112	1174	41	1	2516	1	CDH4	20	60509192	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	2740486	60509192	2516328	526	35516										
LAMA5	3911	broad.mit.edu	37	chr20	60921967	60921967	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgtgtgggaggaggcactcAcactggcactcgttggcact	15	10	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:60921967A>C	uc002ycq.2	-	7	1139	c.1072_splice	c.e7+1	p.S358_splice		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAGGCACTCACACTGGCACT	0.687													0	0	0	0.007835	0	33	52										C	60921967	A	C	60921967	5	2	117	1	0	0	0	0	0	0	1	0	8609	173	6	5	10309	5	LAMA5	20	60921967	Splice_Site	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	412775	60921967	2103553	527	35517										
CABLES2	81928	broad.mit.edu	37	chr20	60968519	60968519	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gttctgtgctggctggtgccGacttggtgggggcaggttta	18	7	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr20:60968519G>A	uc002ycv.2	-	6	864	c.857C>T	c.(856-858)TCG>TTG	p.S286L		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	286					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			GGCTGGTGCCGACTTGGTGGG	0.637													0	0	0	0.00361	0	45	151										A	60968519	G	A	60968519	3	1	117	1	0	0	0	0	1	0	0	0	2530	1059	37	1	599	1	CABLES2	20	60968519	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	46552	60968519	2057001	528	35518										
RNF160	26046	broad.mit.edu	37	chr21	30339132	30339132	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttcccagccttcaatcttctCtccttctgaagatacacatt	3	14	4	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:30339132C>G	uc002ymr.2	-	10	1832	c.1819G>C	c.(1819-1821)GAG>CAG	p.E607Q	RNF160_uc010gll.1_RNA	NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	561							ligase activity|zinc ion binding				0						TCAATCTTCTCTCCTTCTGAA	0.348													0	0	0	0.001855	0	13	7										G	30339132	C	G	30339132	3	3	117	1	0	0	0	0	1	0	0	0	13455	922	32	1	3703	1	RNF160	21	30339132	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		30339132	17790763	529	35519										
GRIK1	2897	broad.mit.edu	37	chr21	30934029	30934029	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtttctctgcgtcacatactCaatgctggtggactccatca	8	12	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:30934029C>G	uc002yno.1	-	15	2736	c.2272G>C	c.(2272-2274)GAG>CAG	p.E758Q	GRIK1_uc002ynn.2_Missense_Mutation_p.E743Q|GRIK1_uc011acs.1_Missense_Mutation_p.E758Q|GRIK1_uc011act.1_Missense_Mutation_p.E619Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	758	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GTCACATACTCAATGCTGGTG	0.547													0	0	0	0.00361	0	48	31										G	30934029	C	G	30934029	3	3	117	1	0	0	0	0	1	0	0	0	6773	835	29	1	656	1	GRIK1	21	30934029	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	594897	30934029	17195866	530	35520										
GRIK1	2897	broad.mit.edu	37	chr21	31066295	31066295	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tggtgttaggcatcagggttCggtttctgttaatgctggtg	15	5	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:31066295C>T	uc002yno.1	-	2	670	c.206G>A	c.(205-207)CGA>CAA	p.R69Q	GRIK1_uc002ynn.2_Missense_Mutation_p.R69Q|GRIK1_uc011acs.1_Missense_Mutation_p.R69Q|GRIK1_uc011act.1_Intron|GRIK1_uc010glq.1_Intron|GRIK1_uc002ynr.2_Missense_Mutation_p.R69Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	69	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CATCAGGGTTCGGTTTCTGTT	0.398													0	0	0	0.012213	0	26	71										T	31066295	C	T	31066295	3	4	117	1	0	0	0	0	1	0	0	0	6773	884	31	1	2774	1	GRIK1	21	31066295	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	132266	31066295	17063600	531	35521										
SON	6651	broad.mit.edu	37	chr21	34926321	34926321	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgcaggagaaactctatcttCtactggtccttttgctctgg	9	10	4	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:34926321C>T	uc002yse.1	+	3	4833	c.4784C>T	c.(4783-4785)TCT>TTT	p.S1595F	SON_uc002ysb.1_Missense_Mutation_p.S1595F|SON_uc002ysc.2_Missense_Mutation_p.S1595F|SON_uc002ysd.2_Missense_Mutation_p.S586F|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S586F	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1595					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						ACTCTATCTTCTACTGGTCCT	0.413													0	0	0	0.007291	0	25	51										T	34926321	C	T	34926321	3	4	117	1	0	0	0	0	1	0	0	0	14926	913	32	1	4794	1	SON	21	34926321	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	3860026	34926321	13203574	532	35522										
SLC5A3	6526	broad.mit.edu	37	chr21	35468011	35468011	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcattggcatgactgctttgCtgactgtcaccggaggcctt	11	11	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:35468011C>T	uc002yto.2	+	2	1026	c.514C>T	c.(514-516)CTG>TTG	p.L172L	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	172	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						GACTGCTTTGCTGACTGTCAC	0.473													0	0	0	0.004878	0	29	84										T	35468011	C	T	35468011	2	4	117	1	0	0	0	0	0	0	0	1	14666	796	28	2		2	SLC5A3	21	35468011	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	541690	35468011	12661884	533	35523										
COL18A1	80781	broad.mit.edu	37	chr21	46876059	46876059	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcaggccctgggcaccactCacggggccctcagtgccacc	13	18	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:46876059C>G	uc011afs.1	+	1	636	c.615C>G	c.(613-615)CTC>CTG	p.L205L	COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Silent_p.L205L	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	205					cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GGGCACCACTCACGGGGCCCT	0.687													0	0	0	0.010504	0	18	52										G	46876059	C	G	46876059	2	3	117	1	0	0	0	0	0	0	0	1	3675	813	29	1		1	COL18A1	21	46876059	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	11408048	46876059	1253836	534	35524										
COL6A2	1292	broad.mit.edu	37	chr21	47538527	47538527	+	Splice_Site	DEL	G	G	-													0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgattctgcaaacccttccaGggggaccctggccgcccagg							TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr21:47538527delG	uc002zia.1	+	13	1199	c.1117_splice	c.e13-1	p.G373_splice	COL6A2_uc002zhy.1_Splice_Site_p.G373_splice|COL6A2_uc002zhz.1_Splice_Site_p.G373_splice|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor						axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AACCCTTCCAGGGGGACCCTG	0.687																		21	25	---	---								-	47538527	G	-	47538527	8	5	117	1	0	1	0	1	0	0	1	0	3700	1014	35	0	1162	0	COL6A2	21	47538527	Splice_Site	DEL	G	TCGA-GV-A3JZ-01A-11D-A21A-08	662468	47538527	591368	535	35525										
IL17RA	23765	broad.mit.edu	37	chr22	17579721	17579721	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcctgcagctgaacaccaatGaacgtttgtgcgtcaggttt	10	10	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:17579721G>A	uc002zly.2	+	4	500	c.367G>A	c.(367-369)GAA>AAA	p.E123K	IL17RA_uc010gqt.2_Missense_Mutation_p.E123K	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	123	Extracellular (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		GAACACCAATGAACGTTTGTG	0.512													0	0	0	0.008361	0	26	102										A	17579721	G	A	17579721	3	1	117	1	0	0	0	0	1	0	0	0	7639	1291	45	1	381	1	IL17RA	22	17579721	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08		17579721	33724845	536	35526										
CLTCL1	8218	broad.mit.edu	37	chr22	19196576	19196576	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	agcaggctcattgcatctctCcgcaaactcatatgcccggt	8	14	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:19196576C>G	uc002zpb.2	-	21	3373	c.3298G>C	c.(3298-3300)GAG>CAG	p.E1100Q	CLTCL1_uc011agv.1_Missense_Mutation_p.E1100Q|CLTCL1_uc011agw.1_Missense_Mutation_p.E1100Q|CLTCL1_uc011agt.1_5'Flank|CLTCL1_uc011agu.1_5'Flank|CLTCL1_uc010grm.1_5'UTR|CLTCL1_uc002zpe.2_Missense_Mutation_p.E60Q|CLTCL1_uc002zpd.1_Missense_Mutation_p.E60Q	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1100	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTGCATCTCTCCGCAAACTCA	0.517			T	NaN	ALCL								0	0	0	0.00308	0	7	16										G	19196576	C	G	19196576	3	3	117	1	0	0	0	0	1	0	0	0	3567	864	30	1	1672	1	CLTCL1	22	19196576	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1616855	19196576	32107990	537	35527										
RTN4R	65078	broad.mit.edu	37	chr22	20230351	20230351	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctccaggagggccaggccaGtgaaggcagccgcatcaatt	14	12	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:20230351G>C	uc002zrv.2	-	2	506	c.305C>G	c.(304-306)ACT>AGT	p.T102S	RTN4R_uc002zru.2_5'UTR	NM_023004	NP_075380	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor precursor	102	LRR 2.				axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity				0	Colorectal(54;0.0993)					GGCCAGGCCAGTGAAGGCAGC	0.637													0	0	0	0.00361	0	48	25										C	20230351	G	C	20230351	3	2	117	1	0	0	0	0	1	0	0	0	13730	1029	36	4	1120	4	RTN4R	22	20230351	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1033775	20230351	31074215	538	35528										
SNAP29	9342	broad.mit.edu	37	chr22	21213633	21213633	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aggttggggtcgcctcttccGaggtgagcctggggcagggc	19	10	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:21213633G>A	uc011ahw.1	+	1	342	c.235G>A	c.(235-237)GAG>AAG	p.E79K	PI4KA_uc002zsz.3_5'Flank|PI4KA_uc010gsq.1_5'Flank	NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	79	Potential.				cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			CGCCTCTTCCGAGGTGAGCCT	0.612													0	0	0	0.003755	0	27	44										A	21213633	G	A	21213633	3	1	117	1	0	0	0	0	1	0	0	0	14831	1059	37	1	237	1	SNAP29	22	21213633	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	983282	21213633	30090933	539	35529										
AP1B1	162	broad.mit.edu	37	chr22	29738343	29738343	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcttctttagaaagagtttCacaatggctgtcagcagctg	11	8	3	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:29738343C>T	uc003afj.2	-	12	1651	c.1467G>A	c.(1465-1467)GTG>GTA	p.V489V	AP1B1_uc003afi.2_Silent_p.V489V|AP1B1_uc003afk.2_Silent_p.V489V|AP1B1_uc003afl.2_Silent_p.V489V|AP1B1_uc011ako.1_Silent_p.V42V	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	489					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GAAAGAGTTTCACAATGGCTG	0.582													0	0	0	0.00361	0	61	19										T	29738343	C	T	29738343	2	4	117	1	0	0	0	0	0	0	0	1	731	813	29	1		1	AP1B1	22	29738343	Silent	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	8524710	29738343	21566223	540	35530										
ASCC2	84164	broad.mit.edu	37	chr22	30185085	30185085	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tcttgtcgccttgttggcttCcttcttcctgcgttcctggg	10	13	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:30185085C>A	uc003agr.2	-	20	2296	c.2191G>T	c.(2191-2193)GAA>TAA	p.E731*	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Nonsense_Mutation_p.E731*|ASCC2_uc011akr.1_Nonsense_Mutation_p.E655*	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	731					regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			TTGTTGGCTTCCTTCTTCCTG	0.622													1	0	2.43435e-39	0.00361	2.65603e-39	119	403										A	30185085	C	A	30185085	4	1	117	1	0	0	0	0	0	1	0	0	1032	864	30	3	86	3	ASCC2	22	30185085	Nonsense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	446742	30185085	21119481	541	35531										
SLC5A4	6527	broad.mit.edu	37	chr22	32616910	32616910	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgtaaaccaaatattaccttCttcaacaccatcatctgttt	2	11	4	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:32616910C>T	uc003ami.2	-	14	1767	c.1765G>A	c.(1765-1767)GAA>AAA	p.E589K		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	589	Cytoplasmic (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						ATATTACCTTCTTCAACACCA	0.408													0	0	0	0.00361	0	47	65										T	32616910	C	T	32616910	3	4	117	1	0	0	0	0	1	0	0	0	14667	922	32	1	222	1	SLC5A4	22	32616910	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2431825	32616910	18687656	542	35532										
RASD2	23551	broad.mit.edu	37	chr22	35947637	35947637	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaagcagatcctggaggtcaAgtcctgcctgaagaacaaga	12	9	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:35947637A>G	uc003anx.2	+	3	564	c.359A>G	c.(358-360)AAG>AGG	p.K120R	RASD2_uc003any.2_Missense_Mutation_p.K120R	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	120					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CTGGAGGTCAAGTCCTGCCTG	0.597													0	0	0	0.003755	0	28	98										G	35947637	A	G	35947637	3	3	117	1	0	0	0	0	1	0	0	0	13067	72	3	5	365	5	RASD2	22	35947637	Missense_Mutation	SNP	A	TCGA-GV-A3JZ-01A-11D-A21A-08	3330727	35947637	15356929	543	35533										
MYH9	4627	broad.mit.edu	37	chr22	36681357	36681357	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gctgcgctccaggttcaggtCggtgttgatctggtcgatct	14	10	3	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:36681357C>T	uc003apg.2	-	38	5524	c.5293G>A	c.(5293-5295)GAC>AAC	p.D1765N		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1765	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						AGGTTCAGGTCGGTGTTGATC	0.617			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.007835	0	36	118										T	36681357	C	T	36681357	3	4	117	1	0	0	0	0	1	0	0	0	10042	884	31	1	605	1	MYH9	22	36681357	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	733720	36681357	14623209	544	35534										
TXN2	25828	broad.mit.edu	37	chr22	36876824	36876824	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gaggggtggccactgaccctGagagggcttcctggagatga	17	9	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:36876824G>C	uc003apk.1	-	2	138	c.61C>G	c.(61-63)CAG>GAG	p.Q21E	TXN2_uc003apl.1_RNA	NM_012473	NP_036605	Q99757	THIOM_HUMAN	thioredoxin 2 precursor	21					cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	mitochondrion|nucleolus	electron carrier activity				0						CACTGACCCTGAGAGGGCTTC	0.577													0	0	0	0.00333	0	23	78										C	36876824	G	C	36876824	3	2	117	1	0	0	0	0	1	0	0	0	16788	1299	45	1	451	1	TXN2	22	36876824	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	195467	36876824	14427742	545	35535										
FOXRED2	80020	broad.mit.edu	37	chr22	36900716	36900716	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	attctggcctacaaagtcctCagggtccacggacacggact	10	13	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:36900716C>T	uc003apn.3	-	2	733	c.625G>A	c.(625-627)GAG>AAG	p.E209K	FOXRED2_uc003apo.3_Missense_Mutation_p.E209K|FOXRED2_uc003app.3_Missense_Mutation_p.E209K	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	209					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						ACAAAGTCCTCAGGGTCCACG	0.527													0	0	0	0.00361	0	63	44										T	36900716	C	T	36900716	3	4	117	1	0	0	0	0	1	0	0	0	6034	835	29	1	1457	1	FOXRED2	22	36900716	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	23892	36900716	14403850	546	35536										
RPL3	6122	broad.mit.edu	37	chr22	39712783	39712783	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	aagtccttctccagctgcttCttgccatcctcatcctgcca	5	17	3	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:39712783C>G	uc003axi.2	-	4	497	c.429G>C	c.(427-429)AAG>AAC	p.K143N	RPL3_uc003axh.2_Intron|RPL3_uc003axj.2_5'UTR|RPL3_uc010gxx.2_Missense_Mutation_p.K91N|RPL3_uc003axg.2_Missense_Mutation_p.K91N|RPL3_uc003axk.1_5'UTR	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	143					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					CCAGCTGCTTCTTGCCATCCT	0.547											OREG0026575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	106										G	39712783	C	G	39712783	3	3	117	1	0	0	0	0	1	0	0	0	13579	912	32	1	810	1	RPL3	22	39712783	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	2812067	39712783	11591783	547	35537										
FAM83F	113828	broad.mit.edu	37	chr22	40417887	40417887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcgcccaatggcatggccaGctctgtctccaccgagacct	11	16	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:40417887G>A	uc003ayk.1	+	4	1467	c.1373G>A	c.(1372-1374)AGC>AAC	p.S458N		NM_138435	NP_612444	Q8NEG4	FA83F_HUMAN	hypothetical protein LOC113828	458										breast(1)	1						GGCATGGCCAGCTCTGTCTCC	0.657													0	0	0	0.010504	0	14	80										A	40417887	G	A	40417887	3	1	117	1	0	0	0	0	1	0	0	0	5638	971	34	2	1387	2	FAM83F	22	40417887	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	705104	40417887	10886679	548	35538										
EP300	2033	broad.mit.edu	37	chr22	41537064	41537064	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ttcaaaaggcggaatactacCaccttctagctgagaaaatc	7	10	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:41537064C>G	uc003azl.3	+	10	2286	c.1891C>G	c.(1891-1893)CAC>GAC	p.H631D		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	631	KIX.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GGAATACTACCACCTTCTAGC	0.373			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.006122	0	16	15										G	41537064	C	G	41537064	3	3	117	1	0	0	0	0	1	0	0	0	5148	594	21	4	1929	4	EP300	22	41537064	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	1119177	41537064	9767502	549	35539										
TCF20	6942	broad.mit.edu	37	chr22	42607575	42607575	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgattaaggggttttgagaaGaatgatcctcctggcctgga	13	6	0	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:42607575G>C	uc003bcj.1	-	1	3871	c.3737C>G	c.(3736-3738)TCT>TGT	p.S1246C	TCF20_uc003bck.1_Missense_Mutation_p.S1246C|TCF20_uc003bnt.2_Missense_Mutation_p.S1246C	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GTTTTGAGAAGAATGATCCTC	0.483													0	0	0	0.00333	0	21	60										C	42607575	G	C	42607575	3	2	117	1	0	0	0	0	1	0	0	0	15687	942	33	1	2183	1	TCF20	22	42607575	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1070511	42607575	8696991	550	35540										
CYB5R3	1727	broad.mit.edu	37	chr22	43032768	43032768	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttgatgtccgggctctcgaGggtgatggctggcgtggagc	18	9	1	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chr22:43032768G>A	uc003bcz.2	-	2	190	c.106C>T	c.(106-108)CTC>TTC	p.L36F	CYB5R3_uc010gzc.1_5'UTR|CYB5R3_uc003bcw.2_Missense_Mutation_p.L26F|CYB5R3_uc011aps.1_Missense_Mutation_p.L69F|CYB5R3_uc003bcy.2_Missense_Mutation_p.L13F|CYB5R3_uc003bcx.2_Missense_Mutation_p.L13F	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	36					blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	GGGCTCTCGAGGGTGATGGCT	0.627													0	0	0	0.003271	0	33	28										A	43032768	G	A	43032768	3	1	117	1	0	0	0	0	1	0	0	0	4128	1000	35	2	831	2	CYB5R3	22	43032768	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	425193	43032768	8271798	551	35541										
BCOR	54880	broad.mit.edu	37	chrX	39930340	39930340	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	tgggctgaatttgcacatctCggagtctttggttgctgggt	14	7	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:39930340C>T	uc004den.3	-	6	3416	c.3124G>A	c.(3124-3126)GAG>AAG	p.E1042K	BCOR_uc004dep.3_Missense_Mutation_p.E1042K|BCOR_uc004deo.3_Missense_Mutation_p.E1024K|BCOR_uc004dem.3_Missense_Mutation_p.E1042K	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1042					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TTGCACATCTCGGAGTCTTTG	0.488													0	0	0	0.009535	0	30	2										T	39930340	C	T	39930340	3	4	117	1	0	0	0	0	1	0	0	0	1386	893	31	1	2183	1	BCOR	23	39930340	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08		39930340	115340220	552	35542										
CHST7	56548	broad.mit.edu	37	chrX	46434158	46434158	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggcgtgctggtgcccctgttGcgtgatccaggcctcaacct	13	14	1	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:46434158G>A	uc004dgt.2	+	1	967	c.792G>A	c.(790-792)TTG>TTA	p.L264L		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	264	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						TGCCCCTGTTGCGTGATCCAG	0.657													0	0	0	0.004672	0	3	12										A	46434158	G	A	46434158	2	1	117	1	0	0	0	0	0	0	0	1	3409	1310	46	2		2	CHST7	23	46434158	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	6503818	46434158	108836402	553	35543										
ITIH5L	347365	broad.mit.edu	37	chrX	54783526	54783526	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggagcagactgatggcctcaGggaggatgctagaaggcagc	17	8	1	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:54783526G>T	uc004dtj.2	-	8	3011	c.2981C>A	c.(2980-2982)CCT>CAT	p.P994H		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	994	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GATGGCCTCAGGGAGGATGCT	0.547													1	0	1.00905e-13	0.008871	1.06394e-13	18	22										T	54783526	G	T	54783526	3	4	117	1	0	0	0	0	1	0	0	0	7908	1000	35	4	984	4	ITIH5L	23	54783526	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	8349368	54783526	100487034	554	35544										
ITGB1BP2	26548	broad.mit.edu	37	chrX	70521663	70521663	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	caaccaacgcttccatgtctCtactctgtcgtaacaaaggc	6	14	2	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:70521663C>G	uc004dzr.1	+	1	36	c.7C>G	c.(7-9)CTA>GTA	p.L3V	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_5'UTR	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	3					muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					TTCCATGTCTCTACTCTGTCG	0.507													0	0	0	0.00361	0	46	1										G	70521663	C	G	70521663	3	3	117	1	0	0	0	0	1	0	0	0	7892	912	32	1	9	1	ITGB1BP2	23	70521663	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	15738137	70521663	84748897	555	35545										
SLC16A2	6567	broad.mit.edu	37	chrX	73745728	73745728	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cttaagaagatctacttgcaGgtgagtgtgaccacttgtcc	10	9	1	4			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:73745728G>T	uc004ebt.2	+	4	1558	c.1392G>T	c.(1390-1392)CAG>CAT	p.Q464H	SLC16A2_uc010nlr.1_Missense_Mutation_p.Q139H	NM_006517	NP_006508	P36021	MOT8_HUMAN	solute carrier family 16, member 2	390	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|ovary(1)	3					Pyruvic acid(DB00119)	TCTACTTGCAGGTGAGTGTGA	0.488													1	0	1.50039e-11	0.012319	1.56697e-11	20	23										T	73745728	G	T	73745728	3	4	117	1	0	0	0	0	1	0	0	0	14408	1014	35	4	1406	4	SLC16A2	23	73745728	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	3224065	73745728	81524832	556	35546										
CSTF2	1478	broad.mit.edu	37	chrX	100088252	100088252	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ggttagatgccagaggattaGaggcccgtgcaatggaggcc	16	8	0	3			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:100088252G>A	uc004egh.2	+	11	1349	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	CSTF2_uc010nnd.2_Missense_Mutation_p.E451K|CSTF2_uc004egi.2_Missense_Mutation_p.E414K	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	431	5; approximate.|12 X 5 AA tandem repeats of M-E-A-R-[AG].				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						CAGAGGATTAGAGGCCCGTGC	0.587													0	0	0	0.00499	0	14	3										A	100088252	G	A	100088252	3	1	117	1	0	0	0	0	1	0	0	0	3984	943	33	1	1333	1	CSTF2	23	100088252	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	26342524	100088252	55182308	557	35547										
ARMCX5	64860	broad.mit.edu	37	chrX	101857861	101857861	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cctctggggattcgacctttGaccaagatcccaccttatca	7	14	2	2			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:101857861G>C	uc004ejg.2	+	6	1673	c.792G>C	c.(790-792)TTG>TTC	p.L264F	ARMCX5_uc004ejh.2_Missense_Mutation_p.L264F	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	264							binding			ovary(1)	1						TTCGACCTTTGACCAAGATCC	0.483													0	0	0	0.007835	0	30	52										C	101857861	G	C	101857861	3	2	117	1	0	0	0	0	1	0	0	0	962	1281	45	1	794	1	ARMCX5	23	101857861	Missense_Mutation	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1769609	101857861	53412699	558	35548										
H2BFWT	158983	broad.mit.edu	37	chrX	103267744	103267744	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	cacttgctcctggtgtacctGaggacagccttcgtgccttc	10	14	0	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:103267744G>C	uc004elr.2	-	1	513	c.489C>G	c.(487-489)CTC>CTG	p.L163L		NM_001002916	NP_001002916	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	163					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			ovary(1)	1						TGGTGTACCTGAGGACAGCCT	0.632													0	0	0	0.005524	0	34	7										C	103267744	G	C	103267744	2	2	117	1	0	0	0	0	0	0	0	1	6932	1277	45	1		1	H2BFWT	23	103267744	Silent	SNP	G	TCGA-GV-A3JZ-01A-11D-A21A-08	1409883	103267744	52002816	559	35549										
GPR101	83550	broad.mit.edu	37	chrX	136112978	136112978	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	ccccgtgcttccttccttggCcttcaggctgccgtccttgg	10	17	1	0			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:136112978C>A	uc011mwh.1	-	1	856	c.856G>T	c.(856-858)GCC>TCC	p.A286S		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	286	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CCTTCCTTGGCCTTCAGGCTG	0.612													1	0	7.28744e-38	0.00361	7.93789e-38	89	77										A	136112978	C	A	136112978	3	1	117	1	0	0	0	0	1	0	0	0	6622	739	26	4	673	4	GPR101	23	136112978	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	32845234	136112978	19157582	560	35550										
PLXNB3	5365	broad.mit.edu	37	chrX	153044065	153044065	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.507220216606498	281	3.4583514950438e-106	4.10693667972809	5.10086869842417	3.48747904835764	0.326218016583252	0.530104276947785	213	gtgcccccagaactacacttCtgctccccactgtctggagg	9	16	2	1			TCGA-GV-A3JZ-01A-11D-A21A-08	TCGA-GV-A3JZ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	074fc904-0a0e-4114-b569-89d51e7a89db	bc976042-8abc-4c49-b0f4-abd1c84ef41b	g.chrX:153044065C>G	uc004fii.2	+	35	5735	c.5561C>G	c.(5560-5562)TCT>TGT	p.S1854C	PLXNB3_uc010nuk.2_Missense_Mutation_p.S1877C|PLXNB3_uc011mzd.1_Missense_Mutation_p.S1493C|SRPK3_uc004fik.2_5'UTR|SRPK3_uc010nul.2_5'Flank|SRPK3_uc004fin.2_5'Flank|SRPK3_uc004fil.2_5'Flank|SRPK3_uc004fim.2_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1854	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AACTACACTTCTGCTCCCCAC	0.612													0	0	0	0.000602	0	4	8										G	153044065	C	G	153044065	3	3	117	1	0	0	0	0	1	0	0	0	12125	913	32	1	5813	1	PLXNB3	23	153044065	Missense_Mutation	SNP	C	TCGA-GV-A3JZ-01A-11D-A21A-08	16931087	153044065	2226495	561	35551										
GLTPD1	80772	broad.mit.edu	37	chr1	1262754	1262754	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tgcaggccatggtggcccacGagctgagcaaccggctggtg	16	12	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:1262754G>A	uc001aeo.2	+	3	671	c.256G>A	c.(256-258)GAG>AAG	p.E86K	CPSF3L_uc001aee.1_5'Flank|CPSF3L_uc001aef.1_5'Flank|CPSF3L_uc009vjz.1_5'Flank|CPSF3L_uc010nyj.1_5'Flank|CPSF3L_uc001aeg.1_5'Flank|CPSF3L_uc001aeh.1_5'Flank|CPSF3L_uc001aei.1_5'Flank|CPSF3L_uc001aej.1_5'Flank|CPSF3L_uc001aek.1_5'Flank|CPSF3L_uc001aem.1_5'Flank|CPSF3L_uc001ael.1_5'Flank|CPSF3L_uc001aen.1_5'Flank	NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	86						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGTGGCCCACGAGCTGAGCAA	0.706													0	0	0	0.000602	0	5	15										A	1262754	G	A	1262754	3	1	118	1	0	0	0	0	1	0	0	0	6472	1059	37	1	262	1	GLTPD1	1	1262754	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08		1262754	247987867	1	35552										
PRAMEF12	390999	broad.mit.edu	37	chr1	12835183	12835183	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cctgacaactatggtgcaggCctggcccttcacctgccttc	9	16	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:12835183C>T	uc001aui.2	+	1	200	c.173C>T	c.(172-174)GCC>GTC	p.A58V		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	58										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATGGTGCAGGCCTGGCCCTTC	0.577													0	0	0	0.00499	0	17	76										T	12835183	C	T	12835183	3	4	118	1	0	0	0	0	1	0	0	0	12428	739	26	2	175	2	PRAMEF12	1	12835183	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	11572429	12835183	236415438	2	35553										
UBR4	23352	broad.mit.edu	37	chr1	19473366	19473366	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tccgtaaagtggacaaggttGttggggcgcatgatggcaat	15	6	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:19473366G>T	uc001bbi.2	-	52	7762	c.7758C>A	c.(7756-7758)AAC>AAA	p.N2586K	UBR4_uc001bbk.1_Missense_Mutation_p.N240K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2586					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGACAAGGTTGTTGGGGCGCA	0.517													1	0	9.86323e-18	0.003954	1.13853e-17	25	155										T	19473366	G	T	19473366	3	4	118	1	0	0	0	0	1	0	0	0	16901	1368	48	4	8013	4	UBR4	1	19473366	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	6638183	19473366	229777255	3	35554										
GRIK3	2899	broad.mit.edu	37	chr1	37271789	37271789	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gttcctctgcgtgacgtactCgatggtggtggactccatga	13	10	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:37271789C>A	uc001caz.2	-	14	2365	c.2230G>T	c.(2230-2232)GAG>TAG	p.E744*	GRIK3_uc001cba.1_Nonsense_Mutation_p.E744*	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	744	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGACGTACTCGATGGTGGTG	0.637													1	0	1.66031e-10	0.003954	1.83714e-10	21	34										A	37271789	C	A	37271789	4	1	118	1	0	0	0	0	0	1	0	0	6775	893	31	3	541	3	GRIK3	1	37271789	Nonsense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	17798423	37271789	211978832	4	35555										
RLF	6018	broad.mit.edu	37	chr1	40704314	40704314	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	acaaaccattccattgtattCataaaacttgcaactcctca	2	12	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:40704314C>A	uc001cfc.3	+	8	3971	c.3940C>A	c.(3940-3942)CAT>AAT	p.H1314N	RLF_uc001cfd.3_Missense_Mutation_p.H1005N	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1314	C2H2-type 10.				chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			CCATTGTATTCATAAAACTTG	0.368													1	0	1.12685e-05	0.004482	1.17721e-05	8	37										A	40704314	C	A	40704314	3	1	118	1	0	0	0	0	1	0	0	0	13389	826	29	3	3970	3	RLF	1	40704314	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	3432525	40704314	208546307	5	35556										
TNNI3K	51086	broad.mit.edu	37	chr1	74801782	74801782	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tccacctagcatctgcaaaaGgattcttgaatattgcaaaa	6	9	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:74801782G>C	uc001dgf.1	+	7	682	c.631G>C	c.(631-633)GGA>CGA	p.G211R	TNNI3K_uc001dgc.1_Missense_Mutation_p.G312R|TNNI3K_uc001dgd.2_Missense_Mutation_p.G312R|TNNI3K_uc001dge.1_Missense_Mutation_p.G312R	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	211	ANK 5.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						ATCTGCAAAAGGATTCTTGAA	0.358													0	0	0	0.014323	0	23	41										C	74801782	G	C	74801782	3	2	118	1	0	0	0	0	1	0	0	0	16326	1001	35	4	1012	4	TNNI3K	1	74801782	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	34097468	74801782	174448839	6	35557										
RPF1	80135	broad.mit.edu	37	chr1	84944970	84944970	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aaaggagccaagaccatggcGaaagccggggataagagcag	15	8	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:84944970G>T	uc001djv.3	+	1	51	c.6G>T	c.(4-6)GCG>GCT	p.A2A		NM_025065	NP_079341	Q9H9Y2	RPF1_HUMAN	RNA processing factor 1	2					rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding				0						AGACCATGGCGAAAGCCGGGG	0.552													1	0	1.61879e-10	0.013537	1.80187e-10	11	19										T	84944970	G	T	84944970	2	4	118	1	0	0	0	0	0	0	0	1	13546	1045	37	3		3	RPF1	1	84944970	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	10143188	84944970	164305651	7	35558										
RPL5	6125	broad.mit.edu	37	chr1	93300335	93300335	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ctagtttctctcttactataGattgcttatgcccgtataga	6	9	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:93300335G>A	uc001doz.2	+	4	268	c.190_splice	c.e4-1	p.I64_splice	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_Splice_Site|RPL5_uc001dpb.2_Splice_Site_p.I14_splice|RPL5_uc001dpd.2_5'Flank|SNORD21_uc001dpe.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		TCTTACTATAGATTGCTTATG	0.388													0	0	0	0.01441	0	67	80										A	93300335	G	A	93300335	5	1	118	1	0	0	0	0	0	0	1	0	13597	956	33	1	203	1	RPL5	1	93300335	Splice_Site	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	8355365	93300335	155950286	8	35559										
MYBPHL	343263	broad.mit.edu	37	chr1	109838858	109838858	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cccagagcccccactcacccGgggagaggcgcggacacagc	13	18	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:109838858G>A	uc001dxk.1	-	6	915	c.865C>T	c.(865-867)CGG>TGG	p.R289W	MYBPHL_uc010ovh.1_Missense_Mutation_p.R266W|MYBPHL_uc001dxl.2_Intron	NM_001010985	NP_001010985	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	289	Ig-like C2-type 2.									ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CCACTCACCCGGGGAGAGGCG	0.562													0	0	0	0.009718	0	43	102										A	109838858	G	A	109838858	3	1	118	1	0	0	0	0	1	0	0	0	10015	1115	39	2	211	2	MYBPHL	1	109838858	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	16538523	109838858	139411763	9	35560										
SPAG17	200162	broad.mit.edu	37	chr1	118623868	118623868	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	actaggatctgaaggttctcGgttgctttcattatcttgca	9	8	4	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:118623868G>C	uc001ehk.2	-	15	2133	c.2065C>G	c.(2065-2067)CGA>GGA	p.R689G		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	689						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GAAGGTTCTCGGTTGCTTTCA	0.363													0	0	0	0.00333	0	22	126										C	118623868	G	C	118623868	3	2	118	1	0	0	0	0	1	0	0	0	14979	1124	39	4	4742	4	SPAG17	1	118623868	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	8785010	118623868	130626753	10	35561										
ANKRD35	148741	broad.mit.edu	37	chr1	145563013	145563013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aggccagcgagatgcgggggCgctccgagcagtttgagaaa	17	9	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:145563013C>T	uc001eob.1	+	10	2809	c.2701C>T	c.(2701-2703)CGC>TGC	p.R901C	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.R744C	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	901	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATGCGGGGGCGCTCCGAGCA	0.667													0	0	0	0.004482	0	9	36										T	145563013	C	T	145563013	3	4	118	1	0	0	0	0	1	0	0	0	664	768	27	2	2739	2	ANKRD35	1	145563013	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	26939145	145563013	103687608	11	35562										
GPR89B	51463	broad.mit.edu	37	chr1	147400669	147400669	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	catgagtttcctgatcgactCcagcatcatgattacctccc	6	14	1	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:147400669C>G	uc001epv.3	+	1	164	c.20C>G	c.(19-21)TCC>TGC	p.S7C	GPR89B_uc010ozs.1_Missense_Mutation_p.S7C|GPR89B_uc010ozt.1_5'UTR|GPR89B_uc010ozu.1_5'UTR|GPR89B_uc001epw.3_5'UTR|GPR89B_uc010ozv.1_5'Flank	NM_016334	NP_057418	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89B	7	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(923;0.0276)					CTGATCGACTCCAGCATCATG	0.662													0	0	0	0.005443	0	24	58										G	147400669	C	G	147400669	3	3	118	1	0	0	0	0	1	0	0	0	6719	855	30	1	22	1	GPR89B	1	147400669	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1837656	147400669	101849952	12	35563										
HIST2H2AC	8338	broad.mit.edu	37	chr1	149858559	149858559	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caaacaaggaggcaaggcccGcgccaaggccaagtcgcgct	13	14	0	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:149858559G>T	uc001etd.2	+	1	35	c.35G>T	c.(34-36)CGC>CTC	p.R12L	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	12					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGCAAGGCCCGCGCCAAGGCC	0.582													1	0	3.76054e-38	0.01441	4.5369e-38	74	111										T	149858559	G	T	149858559	3	4	118	1	0	0	0	0	1	0	0	0	7178	1087	38	4	37	4	HIST2H2AC	1	149858559	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	2457890	149858559	99392062	13	35564										
ATP1A4	480	broad.mit.edu	37	chr1	160143967	160143967	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cagtccaagcagcttgatcaGatcctccagaaccaccctga	7	15	1	4			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:160143967G>C	uc001fve.3	+	14	2537	c.2058G>C	c.(2056-2058)CAG>CAC	p.Q686H	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.Q189H	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	686	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			agcttgatcagatcctccaga	0.199													0	0	0	0.012319	0	18	70										C	160143967	G	C	160143967	3	2	118	1	0	0	0	0	1	0	0	0	1131	933	33	1	2112	1	ATP1A4	1	160143967	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	10285408	160143967	89106654	14	35565			1	169		3	3	2422	G		7.473394e-05
ATP1A4	480	broad.mit.edu	37	chr1	160143998	160143998	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	accaccctgagatcgtgtttGctcggacctcccctcagcag	9	16	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:160143998G>C	uc001fve.3	+	14	2568	c.2089G>C	c.(2089-2091)GCT>CCT	p.A697P	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.A200P	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	697	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			gatcgtgtttgctcgGACCTC	0.264													0	0	0	0.006122	0	16	79										C	160143998	G	C	160143998	3	2	118	1	0	0	0	0	1	0	0	0	1131	1319	46	4	2143	4	ATP1A4	1	160143998	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	31	160143998	89106623	15	35566			1	169		3	3	2422	G		7.473394e-05
ATP1A4	480	broad.mit.edu	37	chr1	160146388	160146388	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	attggcatggcctatggacaGattggtgcgcccagaggaat	14	8	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:160146388G>C	uc001fve.3	+	17	3065	c.2586G>C	c.(2584-2586)CAG>CAC	p.Q862H	ATP1A4_uc001fvf.3_Intron|ATP1A4_uc001fvg.2_Missense_Mutation_p.Q365H|ATP1A4_uc001fvh.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	862	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTATGGACAGATTGGTGCGC	0.527													0	0	0	0.00499	0	15	45										C	160146388	G	C	160146388	3	2	118	1	0	0	0	0	1	0	0	0	1131	933	33	1	2652	1	ATP1A4	1	160146388	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	2390	160146388	89104233	16	35567			1	169		3	3	2422	G		7.473394e-05
HSPA6	3310	broad.mit.edu	37	chr1	161495361	161495361	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccatcactcgtgcccgctttGaggaactgtgctcagacctc	9	15	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:161495361G>C	uc001gap.2	+	2	1573	c.913G>C	c.(913-915)GAG>CAG	p.E305Q	HSPA6_uc001gaq.2_Missense_Mutation_p.E305Q	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	305					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TGCCCGCTTTGAGGAACTGTG	0.627													0	0	0	0.010504	0	20	19										C	161495361	G	C	161495361	3	2	118	1	0	0	0	0	1	0	0	0	7415	1291	45	1	915	1	HSPA6	1	161495361	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	1348973	161495361	87755260	17	35568										
ZBTB37	84614	broad.mit.edu	37	chr1	173839474	173839474	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ctctgtgatattgtggtcaaTgtgcaaggacaagcttttcg	11	7	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:173839474T>G	uc009wwp.1	+	3	387	c.111T>G	c.(109-111)AAT>AAG	p.N37K	GAS5_uc001gjj.2_5'Flank|GAS5_uc001gjk.2_5'Flank|SNORD74_uc001gjo.1_5'Flank|ZBTB37_uc001gjp.1_Missense_Mutation_p.N37K|ZBTB37_uc001gjq.3_Missense_Mutation_p.N37K|ZBTB37_uc001gjr.2_Missense_Mutation_p.N37K	NM_001122770	NP_001116242	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37 isoform	37	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGTGGTCAATGTGCAAGGAC	0.507													0	0	0	0.004878	0	39	92										G	173839474	T	G	173839474	3	3	118	1	0	0	0	0	1	0	0	0	17535	1461	51	5	113	5	ZBTB37	1	173839474	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	12344113	173839474	75411147	18	35569										
HMCN1	83872	broad.mit.edu	37	chr1	185987360	185987360	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gatgaaagggatggattcaaGattttattaaatggacgcaa	11	3	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:185987360G>C	uc001grq.1	+	34	5575	c.5346G>C	c.(5344-5346)AAG>AAC	p.K1782N		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1782	Ig-like C2-type 15.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATGGATTCAAGATTTTATTAA	0.398													0	0	0	0.008361	0	30	90										C	185987360	G	C	185987360	3	2	118	1	0	0	0	0	1	0	0	0	7220	933	33	1	5480	1	HMCN1	1	185987360	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	12147886	185987360	63263261	19	35570										
CFHR5	81494	broad.mit.edu	37	chr1	196967415	196967415	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tgtataaacgggaaatggaaTcctgaagtagactgcacagg	12	6	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:196967415T>A	uc001gts.3	+	7	1256	c.1128T>A	c.(1126-1128)AAT>AAA	p.N376K		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	376	Sushi 6.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GGAAATGGAATCCTGAAGTAG	0.294													0	0	0	0.013537	0	10	29										A	196967415	T	A	196967415	3	1	118	1	0	0	0	0	1	0	0	0	3288	1432	50	5	1154	5	CFHR5	1	196967415	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	10980055	196967415	52283206	20	35571										
ZP4	57829	broad.mit.edu	37	chr1	238048117	238048117	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggatggtgtctcagcaggctGgcagactgacacgctgcagt	15	10	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:238048117G>T	uc001hym.2	-	10	1342	c.1342C>A	c.(1342-1344)CAG>AAG	p.Q448K	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	448	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCAGCAGGCTGGCAGACTGAC	0.498													1	0	2.74318e-10	0.006214	3.0175e-10	9	23										T	238048117	G	T	238048117	3	4	118	1	0	0	0	0	1	0	0	0	18215	1357	47	4	292	4	ZP4	1	238048117	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	41080702	238048117	11202504	21	35572										
OR2T12	127064	broad.mit.edu	37	chr1	248458286	248458286	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gagcattaacacacagcagaTgtacatggcgttttcgaaga	10	8	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr1:248458286T>A	uc010pzj.1	-	1	595	c.595A>T	c.(595-597)ATC>TTC	p.I199F		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ACACAGCAGATGTACATGGCG	0.537													0	0	0	0.004007	0	15	79										A	248458286	T	A	248458286	3	1	118	1	0	0	0	0	1	0	0	0	11019	1464	51	5	370	5	OR2T12	1	248458286	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	10410169	248458286	792335	22	35573										
PXDN	7837	broad.mit.edu	37	chr2	1652948	1652948	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cagcgggccccgctcctggcCcgggagtcattgggggggat	18	13	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:1652948C>T	uc002qxa.2	-	17	2668	c.2604G>A	c.(2602-2604)CGG>CGA	p.R868R		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	868					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGCTCCTGGCCCGGGAGTCAT	0.662													0	0	0	0.010729	0	10	21										T	1652948	C	T	1652948	2	4	118	1	0	0	0	0	0	0	0	1	12847	610	22	2		2	PXDN	2	1652948	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		1652948	241546425	23	35574										
TTC15	51112	broad.mit.edu	37	chr2	3425691	3425691	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cagcagtggacctgtgcggaCgtctcctcacagcccacggc	12	16	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:3425691C>T	uc002qxm.1	+	4	1410	c.1204C>T	c.(1204-1206)CGT>TGT	p.R402C	TTC15_uc002qxn.1_Missense_Mutation_p.R402C|TTC15_uc010ewm.1_Missense_Mutation_p.R402C	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	402							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CCTGTGCGGACGTCTCCTCAC	0.587													0	0	0	0.006214	0	9	22										T	3425691	C	T	3425691	3	4	118	1	0	0	0	0	1	0	0	0	16679	536	19	2	1214	2	TTC15	2	3425691	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1772743	3425691	239773682	24	35575										
ZFP36L2	678	broad.mit.edu	37	chr2	43452553	43452554	+	Frame_Shift_Ins	INS	-	-	C													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggtgcaggaggtgctggctgINScgatcgccgttctcgctaaa							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:43452553_43452554insC	uc002rsv.3	-	2	680_681	c.389_390insG	c.(388-390)CGCfs	p.R130fs	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	130					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GGTGCTGGCTGCGATCGCCGTT	0.658																		11	16	---	---								C	43452554	-	C	43452553	7	5	118	1	0	1	1	0	0	0	0	0	17644	1306	46	0	1098	0	ZFP36L2	2	43452553	Frame_Shift_Ins	INS	-	TCGA-GV-A3QF-01A-31D-A22Z-08	40026862	43452553	199746820	25	35576										
C2orf86	51057	broad.mit.edu	37	chr2	63660991	63660991	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccagtggccaccagcaaacaActctatcatgaacacagttg	7	13	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:63660991A>G	uc002sch.2	-	9	1159	c.713T>C	c.(712-714)GTT>GCT	p.V238A	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.V79A|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.V46A|C2orf86_uc002sci.1_Missense_Mutation_p.V214A|C2orf86_uc010fcr.1_Missense_Mutation_p.V128A	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	238					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						CCAGCAAACAACTCTATCATG	0.433													0	0	0	0.008871	0	16	27										G	63660991	A	G	63660991	3	3	118	1	0	0	0	0	1	0	0	0	2201	43	2	5	1567	5	C2orf86	2	63660991	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	20208438	63660991	179538382	26	35577										
DYSF	8291	broad.mit.edu	37	chr2	71894600	71894600	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggcctggtcccggagcacgtGgagtcacggcccctctacag	14	15	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:71894600G>A	uc002sie.2	+	47	5671	c.5295G>A	c.(5293-5295)GTG>GTA	p.V1765V	DYSF_uc010feg.2_Silent_p.V1796V|DYSF_uc010feh.2_Silent_p.V1772V|DYSF_uc002sig.3_Silent_p.V1751V|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.V1786V|DYSF_uc010fef.2_Silent_p.V1803V|DYSF_uc010fei.2_Silent_p.V1782V|DYSF_uc010fek.2_Silent_p.V1783V|DYSF_uc010fej.2_Silent_p.V1773V|DYSF_uc010fel.2_Silent_p.V1752V|DYSF_uc010feo.2_Silent_p.V1797V|DYSF_uc010fem.2_Silent_p.V1787V|DYSF_uc010fen.2_Silent_p.V1804V|DYSF_uc002sif.2_Silent_p.V1766V|DYSF_uc010yqy.1_Silent_p.V646V|DYSF_uc010yqz.1_Silent_p.V526V	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1765	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CGGAGCACGTGGAGTCACGGC	0.652													0	0	0	0.007413	0	20	42										A	71894600	G	A	71894600	2	1	118	1	0	0	0	0	0	0	0	1	4859	1335	47	2		2	DYSF	2	71894600	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	8233609	71894600	171304773	27	35578										
CNGA3	1261	broad.mit.edu	37	chr2	98986521	98986521	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agaccgagatctcaatcgcgCtgaaaatggcctcagcaggt	11	11	2	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:98986521C>T	uc002syt.2	+	2	500	c.83C>T	c.(82-84)GCT>GTT	p.A28V	CNGA3_uc002syu.2_Missense_Mutation_p.A28V	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	28					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CTCAATCGCGCTGAAAATGGC	0.502													0	0	0	0.007413	0	19	27										T	98986521	C	T	98986521	3	4	118	1	0	0	0	0	1	0	0	0	3598	797	28	2	85	2	CNGA3	2	98986521	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	27091921	98986521	144212852	28	35579										
TBC1D8	11138	broad.mit.edu	37	chr2	101670703	101670703	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttctccgcctcggggaagttGaacctggcctcgaacttcac	10	14	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:101670703G>A	uc010fiv.2	-	4	584	c.453C>T	c.(451-453)TTC>TTT	p.F151F	TBC1D8_uc010yvw.1_Silent_p.F166F|TBC1D8_uc002tau.3_5'UTR	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	151	GRAM 1.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CGGGGAAGTTGAACCTGGCCT	0.622													0	0	0	0.001984	0	7	12										A	101670703	G	A	101670703	2	1	118	1	0	0	0	0	0	0	0	1	15622	1281	45	1		1	TBC1D8	2	101670703	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	2684182	101670703	141528670	29	35580										
LRP1B	53353	broad.mit.edu	37	chr2	141812708	141812708	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tgcatgacctgccatcacttCccaagttgaagccagtcctg	8	14	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:141812708C>A	uc002tvj.1	-	10	2501	c.1529G>T	c.(1528-1530)GGA>GTA	p.G510V	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	510	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCATCACTTCCCAAGTTGAA	0.433										TSP Lung(27;0.18)			1	0	1.58986e-06	0.008291	1.69888e-06	10	62										A	141812708	C	A	141812708	3	1	118	1	0	0	0	0	1	0	0	0	8955	855	30	3	12598	3	LRP1B	2	141812708	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	40142005	141812708	101386665	30	35581										
TANC1	85461	broad.mit.edu	37	chr2	160074029	160074029	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cctgactgccgccgcaggaaGagggaagctggaggtctgtg	17	10	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:160074029G>A	uc002uag.2	+	20	3540	c.3266G>A	c.(3265-3267)AGA>AAA	p.R1089K	TANC1_uc010zcm.1_Missense_Mutation_p.R1081K|TANC1_uc010fom.1_Missense_Mutation_p.R895K|TANC1_uc010fon.2_5'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1089	ANK 6.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						GCCGCAGGAAGAGGGAAGCTG	0.522													0	0	0	0.004289	0	35	202										A	160074029	G	A	160074029	3	1	118	1	0	0	0	0	1	0	0	0	15541	942	33	1	3336	1	TANC1	2	160074029	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	18261321	160074029	83125344	31	35582										
SCN1A	6323	broad.mit.edu	37	chr2	166870384	166870384	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cttcttccacattgatttgaCaacacttgaatctttgtaca	4	10	2	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:166870384C>A	uc010zcz.1	-	18	3560	c.3542G>T	c.(3541-3543)TGT>TTT	p.C1181F	SCN1A_uc002udo.3_Missense_Mutation_p.C1061F|SCN1A_uc010fpk.2_Missense_Mutation_p.C1033F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1192						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ATTGATTTGACAACACTTGAA	0.388													1	0	1.76847e-28	0.01441	2.09306e-28	70	100										A	166870384	C	A	166870384	3	1	118	1	0	0	0	0	1	0	0	0	13914	478	17	4	2490	4	SCN1A	2	166870384	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	6796355	166870384	76328989	32	35583										
PDE11A	50940	broad.mit.edu	37	chr2	178545579	178545579	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tatatcacgatggtttttgaTgttccaatcgtattctcctt	6	8	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:178545579T>G	uc002ulq.2	-	16	2716	c.2398A>C	c.(2398-2400)ATC>CTC	p.I800L	PDE11A_uc002ulp.2_Missense_Mutation_p.I356L|PDE11A_uc002ulr.2_Missense_Mutation_p.I550L|PDE11A_uc002uls.1_Missense_Mutation_p.I442L|PDE11A_uc002ult.1_Missense_Mutation_p.I550L|PDE11A_uc002ulu.1_Missense_Mutation_p.I442L	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	800	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGGTTTTTGATGTTCCAATCG	0.318									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.004482	0	7	39										G	178545579	T	G	178545579	3	3	118	1	0	0	0	0	1	0	0	0	11631	1464	51	5	423	5	PDE11A	2	178545579	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	11675195	178545579	64653794	33	35584										
TTN	7273	broad.mit.edu	37	chr2	179575634	179575634	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caagacggatgtcaaagaagGgtgggttcttcccctctaat	11	9	3	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:179575634G>T	uc010zfg.1	-	95	24682	c.24458C>A	c.(24457-24459)CCC>CAC	p.P8153H	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P4814H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9080							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCAAAGAAGGGTGGGTTCTT	0.483													1	0	0.00621372	0.006214	0.00634953	8	92										T	179575634	G	T	179575634	3	4	118	1	0	0	0	0	1	0	0	0	16732	1232	43	4	76399	4	TTN	2	179575634	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	1030055	179575634	63623739	34	35585										
TTN	7273	broad.mit.edu	37	chr2	179644785	179644785	+	Nonsense_Mutation	SNP	A	A	T													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tggccattttcttcctaattAaggcttgttctttttcatac							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:179644785A>T	uc010zfg.1	-	22	3895	c.3671T>A	c.(3670-3672)TTA>TAA	p.L1224*	TTN_uc010zfh.1_Nonsense_Mutation_p.L1178*|TTN_uc010zfi.1_Nonsense_Mutation_p.L1178*|TTN_uc010zfj.1_Nonsense_Mutation_p.L1178*|TTN_uc002unb.2_Nonsense_Mutation_p.L1224*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1224							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCCTAATTAAGGCTTGTtc	0.308													0	0	0	0.003271	0	35	61										T	179644785	A	T	179644785	4	4	118	1	0	0	0	0	0	1	0	0	16732	372	13	5	107681	5	TTN	2	179644785	Nonsense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	69151	179644785	63554588	35	35586	186	2								
TTN	7273	broad.mit.edu	37	chr2	179644787	179644787	+	Silent	SNP	G	G	T													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gccattttcttcctaattaaGgcttgttctttttcatactc							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:179644787G>T	uc010zfg.1	-	22	3893	c.3669C>A	c.(3667-3669)GCC>GCA	p.A1223A	TTN_uc010zfh.1_Silent_p.A1177A|TTN_uc010zfi.1_Silent_p.A1177A|TTN_uc010zfj.1_Silent_p.A1177A|TTN_uc002unb.2_Silent_p.A1223A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1223							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTAATTAAGGCTTGTtctt	0.313													1	0	1.56442e-22	0.012213	1.81706e-22	33	62										T	179644787	G	T	179644787	2	4	118	1	0	0	0	0	0	0	0	1	16732	987	35	4		4	TTN	2	179644787	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	2	179644787	63554586	36	35587	186	2								
ANKRD44	91526	broad.mit.edu	37	chr2	197889932	197889932	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcacttacagctaagtggagTggactcttagtagcaccaga	10	9	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:197889932T>A	uc002uua.1	-	17	1712	c.1635A>T	c.(1633-1635)CCA>CCT	p.P545P	ANKRD44_uc002utz.3_Silent_p.P277P	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	570	ANK 17.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTAAGTGGAGTGGACTCTTAG	0.383													0	0	0	0.009535	0	30	51										A	197889932	T	A	197889932	2	1	118	1	0	0	0	0	0	0	0	1	672	1683	59	5		5	ANKRD44	2	197889932	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	18245145	197889932	45309441	37	35588										
SF3B1	23451	broad.mit.edu	37	chr2	198265453	198265453	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cattacctctgtagtctgttCttggaaagcataaagaatac	7	8	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:198265453C>T	uc002uue.2	-	18	2752	c.2704G>A	c.(2704-2706)GAA>AAA	p.E902K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	902					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTAGTCTGTTCTTGGAAAGCA	0.318													0	0	0	0.003954	0	25	50										T	198265453	C	T	198265453	3	4	118	1	0	0	0	0	1	0	0	0	14149	922	32	1	1242	1	SF3B1	2	198265453	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	375521	198265453	44933920	38	35589										
MAP2	4133	broad.mit.edu	37	chr2	210559447	210559447	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	actggcttgcccccggtaacTgatgaaaaccatgtcattgt	9	11	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:210559447T>C	uc002vde.1	+	7	2801	c.2553T>C	c.(2551-2553)ACT>ACC	p.T851T	MAP2_uc002vdc.1_Silent_p.T851T|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.T847T	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	851					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CCCCGGTAACTGATGAAAACC	0.493													0	0	0	0.001855	0	13	68										C	210559447	T	C	210559447	2	2	118	1	0	0	0	0	0	0	0	1	9235	1567	55	5		5	MAP2	2	210559447	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	12293994	210559447	32639926	39	35590										
SMARCAL1	50485	broad.mit.edu	37	chr2	217300080	217300080	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggccttccttcggtggctgcCatctctgagcccagattgca	11	14	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:217300080C>T	uc002vgc.3	+	9	1835	c.1505C>T	c.(1504-1506)CCA>CTA	p.P502L	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.P502L|SMARCAL1_uc010fvg.2_Missense_Mutation_p.P502L	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	502	Helicase ATP-binding.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CGGTGGCTGCCATCTCTGAGC	0.547									Schimke_Immuno-Osseous_Dysplasia				0	0	0	0.003163	0	13	62										T	217300080	C	T	217300080	3	4	118	1	0	0	0	0	1	0	0	0	14773	594	21	2	1531	2	SMARCAL1	2	217300080	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	6740633	217300080	25899293	40	35591										
TNS1	7145	broad.mit.edu	37	chr2	218713307	218713307	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggtgaccccgtccagagaagAgagtgtgcccatgctgcccg	14	13	0	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:218713307A>G	uc002vgt.2	-	17	1956	c.1558T>C	c.(1558-1560)TCT>CCT	p.S520P	TNS1_uc002vgr.2_Missense_Mutation_p.S520P|TNS1_uc002vgs.2_Missense_Mutation_p.S520P|TNS1_uc010zjv.1_Missense_Mutation_p.S520P|TNS1_uc010fvj.1_Missense_Mutation_p.S588P|TNS1_uc010fvk.1_Missense_Mutation_p.S645P|TNS1_uc010fvi.1_Missense_Mutation_p.S207P	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	520						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCCAGAGAAGAGAGTGTGCCC	0.592													0	0	0	0.004007	0	14	62										G	218713307	A	G	218713307	3	3	118	1	0	0	0	0	1	0	0	0	16340	304	11	5	3717	5	TNS1	2	218713307	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	1413227	218713307	24486066	41	35592										
IHH	3549	broad.mit.edu	37	chr2	219924972	219924972	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccttgaagcgctcggagctgCgagcgatcttgccttcatag	12	12	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:219924972C>T	uc002vjo.1	-	1	218	c.218G>A	c.(217-219)CGC>CAC	p.R73H	hsa-mir-3131|MI0014151_5'Flank	NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	73					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCGGAGCTGCGAGCGATCTT	0.612													0	0	0	0.012213	0	32	54										T	219924972	C	T	219924972	3	4	118	1	0	0	0	0	1	0	0	0	7607	768	27	2	1029	2	IHH	2	219924972	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1211665	219924972	23274401	42	35593										
KIF1A	547	broad.mit.edu	37	chr2	241715279	241715279	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agttctcacccaggttttccCggaggagccaggtcaacacg	11	13	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:241715279C>T	uc002vzy.2	-	11	1093	c.947G>A	c.(946-948)CGG>CAG	p.R316Q	KIF1A_uc010fzk.2_Missense_Mutation_p.R316Q|KIF1A_uc002vzz.1_Missense_Mutation_p.R316Q	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	316	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CAGGTTTTCCCGGAGGAGCCA	0.577													0	0	0	0.001168	0	6	24										T	241715279	C	T	241715279	3	4	118	1	0	0	0	0	1	0	0	0	8283	652	23	2	4273	2	KIF1A	2	241715279	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	21790307	241715279	1484094	43	35594										
NEU4	129807	broad.mit.edu	37	chr2	242757712	242757712	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cctccttcctgcccgcagagCgcgtggcttccctgcccgag	11	19	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr2:242757712C>T	uc010fzr.2	+	4	879	c.793C>T	c.(793-795)CGC>TGC	p.R265C	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.R265C|NEU4_uc002wcn.1_Missense_Mutation_p.R277C|NEU4_uc002wco.1_Missense_Mutation_p.R265C|NEU4_uc002wcp.1_Missense_Mutation_p.R277C	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	265						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GCCCGCAGAGCGCGTGGCTTC	0.697													0	0	0	0.000602	0	4	3										T	242757712	C	T	242757712	3	4	118	1	0	0	0	0	1	0	0	0	10344	768	27	2	846	2	NEU4	2	242757712	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1042433	242757712	441661	44	35595										
IL5RA	3568	broad.mit.edu	37	chr3	3139839	3139839	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	acctatagtagagaaaatacTgcgtgtcctcaggggcatct	10	9	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:3139839T>G	uc011ask.1	-	7	1147	c.503A>C	c.(502-504)CAG>CCG	p.Q168P	IL5RA_uc010hbq.2_Missense_Mutation_p.Q168P|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Missense_Mutation_p.Q168P|IL5RA_uc011asl.1_Missense_Mutation_p.Q168P|IL5RA_uc011asm.1_Missense_Mutation_p.Q168P|IL5RA_uc010hbt.2_Missense_Mutation_p.Q168P|IL5RA_uc011asn.1_Missense_Mutation_p.Q168P|IL5RA_uc010hbu.2_Missense_Mutation_p.Q168P	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	168	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		GAGAAAATACTGCGTGTCCTC	0.408													0	0	0	0.006122	0	17	76										G	3139839	T	G	3139839	3	3	118	1	0	0	0	0	1	0	0	0	7700	1580	55	5	813	5	IL5RA	3	3139839	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08		3139839	194882591	45	35596										
PRRT3	285368	broad.mit.edu	37	chr3	9989043	9989043	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cggccgcgccccaggcgcacGacaagccctgcgtcaggagg	15	17	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:9989043G>C	uc003bul.2	-	4	1944	c.1814C>G	c.(1813-1815)TCG>TGG	p.S605W	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	605	Helical; (Potential).					integral to membrane					0						CCAGGCGCACGACAAGCCCTG	0.711													0	0	0	0.000602	0	4	23										C	9989043	G	C	9989043	3	2	118	1	0	0	0	0	1	0	0	0	12611	1059	37	1	1135	1	PRRT3	3	9989043	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	6849204	9989043	188033387	46	35597										
ZNF385D	79750	broad.mit.edu	37	chr3	21465483	21465483	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gatgtgctgtcttctgtagtTtgttgtaaggactgtattta	11	4	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:21465483T>G	uc003cce.2	-	7	1334	c.926A>C	c.(925-927)AAA>ACA	p.K309T		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	309						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CTTCTGTAGTTTGTTGTAAGG	0.423													0	0	0	0.00499	0	12	84										G	21465483	T	G	21465483	3	3	118	1	0	0	0	0	1	0	0	0	17875	1841	64	5	269	5	ZNF385D	3	21465483	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	11476440	21465483	176556947	47	35598										
OSBPL10	114884	broad.mit.edu	37	chr3	32022461	32022461	+	Frame_Shift_Del	DEL	G	G	-													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gagcgccggctccctcctgcGgccgcctcccccggacgggc							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:32022461delG	uc003cev.2	-	2	592	c.211delC	c.(211-213)CGCfs	p.R71fs	OSBPL10_uc011axf.1_Frame_Shift_Del_p.R71fs|ZNF860_uc011axg.1_5'Flank	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	71					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		TCCCTCCTGCGGCCGCCTCCC	0.642																		8	5	---	---								-	32022461	G	-	32022461	7	5	118	1	0	1	0	1	0	0	0	0	11275	1116	39	0	2131	0	OSBPL10	3	32022461	Frame_Shift_Del	DEL	G	TCGA-GV-A3QF-01A-31D-A22Z-08	10556978	32022461	165999969	48	35599										
LRRFIP2	9209	broad.mit.edu	37	chr3	37100399	37100399	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aactgaagcttcagttttctAatctgaaatgaaaataaagg	7	5	3	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:37100399A>C	uc003cgp.2	-	26	2175	c.1752T>G	c.(1750-1752)ATT>ATG	p.I584M	MLH1_uc011aye.1_Intron|LRRFIP2_uc011ayf.1_Missense_Mutation_p.I366M|LRRFIP2_uc003cgr.2_Missense_Mutation_p.I287M|LRRFIP2_uc003cgs.3_Missense_Mutation_p.I287M|LRRFIP2_uc003cgt.3_Missense_Mutation_p.I263M	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	584	Potential.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						TCAGTTTTCTAATCTGAAATG	0.438													0	0	0	0.004482	0	9	59										C	37100399	A	C	37100399	3	2	118	1	0	0	0	0	1	0	0	0	9028	358	13	5	429	5	LRRFIP2	3	37100399	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	5077938	37100399	160922031	49	35600										
PLCD1	5333	broad.mit.edu	37	chr3	38050562	38050562	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agcccccattccacatctccAcggggctgtagttggaggag	12	13	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:38050562A>T	uc003chn.2	-	11	1818	c.1694T>A	c.(1693-1695)GTG>GAG	p.V565E	PLCD1_uc003chm.2_Missense_Mutation_p.V586E	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	565	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		CCACATCTCCACGGGGCTGTA	0.642													0	0	0	0.009096	0	4	29										T	38050562	A	T	38050562	3	4	118	1	0	0	0	0	1	0	0	0	12031	159	6	5	596	5	PLCD1	3	38050562	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	950163	38050562	159971868	50	35601										
TRAK1	22906	broad.mit.edu	37	chr3	42244140	42244140	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cactgagagcatcatgtcccTgggcacgcactcccgcttct	9	16	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:42244140T>C	uc003cky.2	+	13	1856	c.1640T>C	c.(1639-1641)CTG>CCG	p.L547P	TRAK1_uc011azh.1_Missense_Mutation_p.L547P|TRAK1_uc011azi.1_Missense_Mutation_p.L547P|TRAK1_uc003ckz.3_Missense_Mutation_p.L473P|TRAK1_uc011azj.1_Missense_Mutation_p.L473P|TRAK1_uc003cla.2_Missense_Mutation_p.L489P	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	547					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						ATCATGTCCCTGGGCACGCAC	0.622													0	0	0	0.014323	0	22	54										C	42244140	T	C	42244140	3	2	118	1	0	0	0	0	1	0	0	0	16446	1580	55	5	1806	5	TRAK1	3	42244140	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	4193578	42244140	155778290	51	35602										
MST1R	4486	broad.mit.edu	37	chr3	49932949	49932949	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggctccagcagtctggtccaGggatgccaggtcattcaggt	14	11	3	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:49932949G>T	uc003cxy.3	-	13	3259	c.2995C>A	c.(2995-2997)CTG>ATG	p.L999M	MST1R_uc011bdc.1_Translation_Start_Site	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	999	Cytoplasmic (Potential).				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		GTCTGGTCCAGGGATGCCAGG	0.567													1	0	1.75199e-13	0.007291	1.99769e-13	29	57										T	49932949	G	T	49932949	3	4	118	1	0	0	0	0	1	0	0	0	9891	991	35	4	1239	4	MST1R	3	49932949	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	7688809	49932949	148089481	52	35603										
TLR9	54106	broad.mit.edu	37	chr3	52256636	52256636	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agccacgaagctgaagttgtGgcccacgccctgcatgccaa	11	14	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:52256636G>A	uc003dda.1	-	2	2330	c.1696C>T	c.(1696-1698)CAC>TAC	p.H566Y	TLR9_uc003ddb.2_Missense_Mutation_p.H663Y	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	566	LRR 18.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CTGAAGTTGTGGCCCACGCCC	0.627													0	0	0	0.00245	0	14	38										A	52256636	G	A	52256636	3	1	118	1	0	0	0	0	1	0	0	0	15955	1348	47	2	1406	2	TLR9	3	52256636	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	2323687	52256636	145765794	53	35604										
CNTN3	5067	broad.mit.edu	37	chr3	74414794	74414794	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gcttgccctgcattcccaatAaagactgtcctccacggcta	7	15	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:74414794A>G	uc003dpm.1	-	8	1086	c.1006T>C	c.(1006-1008)TAT>CAT	p.Y336H		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	336	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CATTCCCAATAAAGACTGTCC	0.448													0	0	0	0.01441	0	91	201										G	74414794	A	G	74414794	3	3	118	1	0	0	0	0	1	0	0	0	3642	362	13	5	2140	5	CNTN3	3	74414794	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	22158158	74414794	123607636	54	35605										
IFT57	55081	broad.mit.edu	37	chr3	107881334	107881334	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccagtatgttttaataaaagCctgttgctggttctggaata	9	6	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:107881334C>G	uc003dwx.3	-	11	1528	c.1280G>C	c.(1279-1281)GGC>GCC	p.G427A		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	427					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTAATAAAAGCCTGTTGCTGG	0.343													0	0	0	0.01441	0	46	57										G	107881334	C	G	107881334	3	3	118	1	0	0	0	0	1	0	0	0	7562	739	26	4	13	4	IFT57	3	107881334	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	33466540	107881334	90141096	55	35606										
PODXL2	50512	broad.mit.edu	37	chr3	127379999	127379999	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aggataccctgggattctacGcaggtaaagtgaggggcatg	15	7	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:127379999G>A	uc003ejq.2	+	3	1152	c.1128G>A	c.(1126-1128)ACG>ACA	p.T376T		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	376	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						GGGATTCTACGCAGGTAAAGT	0.582													0	0	0	0.010729	0	12	44										A	127379999	G	A	127379999	2	1	118	1	0	0	0	0	0	0	0	1	12181	1074	38	2		2	PODXL2	3	127379999	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	19498665	127379999	70642431	56	35607										
PIK3CB	5291	broad.mit.edu	37	chr3	138474750	138474750	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	acagcagtctgattcacacaTgcaaacatataggagtcaat	7	9	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:138474750T>C	uc011bmq.1	-	2	243	c.243A>G	c.(241-243)GCA>GCG	p.A81A		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	81	PI3K-ABD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						GATTCACACATGCAAACATAT	0.368													0	0	0	0.010504	0	21	99										C	138474750	T	C	138474750	2	2	118	1	0	0	0	0	0	0	0	1	11914	1451	51	5		5	PIK3CB	3	138474750	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	11094751	138474750	59547680	57	35608										
IGSF10	285313	broad.mit.edu	37	chr3	151161553	151161553	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aaggtggtctgtgccaaacaGattggatgcggaacacaagt	13	7	1	1	rs143471166		TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:151161553G>C	uc011bod.1	-	5	5182	c.5182C>G	c.(5182-5184)CTG>GTG	p.L1728V	IGSF10_uc011bob.1_5'Flank|IGSF10_uc011boc.1_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1728	Ig-like C2-type 3.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGCCAAACAGATTGGATGCG	0.517													0	0	0	0.007835	0	41	47										C	151161553	G	C	151161553	3	2	118	1	0	0	0	0	1	0	0	0	7597	933	33	1	2745	1	IGSF10	3	151161553	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	12686803	151161553	46860877	58	35609										
DHX36	170506	broad.mit.edu	37	chr3	154018863	154018863	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cttgtctatttacatgccctTgcatgaaacccctcttaaac	4	13	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:154018863T>C	uc003ezy.3	-	10	1352	c.1271A>G	c.(1270-1272)CAA>CGA	p.Q424R	DHX36_uc010hvq.2_Missense_Mutation_p.Q424R|DHX36_uc003ezz.3_Missense_Mutation_p.Q424R	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	424						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TACATGCCCTTGCATGAAACC	0.328													0	0	0	0.01441	0	60	83										C	154018863	T	C	154018863	3	2	118	1	0	0	0	0	1	0	0	0	4509	1812	63	5	1819	5	DHX36	3	154018863	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	2857310	154018863	44003567	59	35610										
PLD1	5337	broad.mit.edu	37	chr3	171404550	171404550	+	Frame_Shift_Del	DEL	G	G	-													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gaagtggggttttaaaccatGgattaaattgtgatgacttc							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:171404550delG	uc003fhs.2	-	16	1908	c.1792delC	c.(1792-1794)CATfs	p.H598fs	PLD1_uc003fht.2_Intron	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	598	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TTTAAACCATGGATTAAATTG	0.333																		56	153	---	---								-	171404550	G	-	171404550	7	5	118	1	0	1	0	1	0	0	0	0	12045	1348	47	0	1480	0	PLD1	3	171404550	Frame_Shift_Del	DEL	G	TCGA-GV-A3QF-01A-31D-A22Z-08	17385687	171404550	26617880	60	35611										
TP63	8626	broad.mit.edu	37	chr3	189349307	189349307	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caaagacagttgaaggaaatGaattttgaaacttcacggtg	10	5	1	4			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:189349307G>A	uc003fry.2	+	1	92	c.3G>A	c.(1-3)ATG>ATA	p.M1I	TP63_uc003frx.2_Missense_Mutation_p.M1I|TP63_uc003frz.2_Missense_Mutation_p.M1I|TP63_uc010hzc.1_Missense_Mutation_p.M1I	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	1	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGAAGGAAATGAATTTTGAAA	0.373									Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.01441	0	61	127										A	189349307	G	A	189349307	3	1	118	1	0	0	0	0	1	0	0	0	16389	1290	45	1	5	1	TP63	3	189349307	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	17944757	189349307	8673123	61	35612										
HES1	3280	broad.mit.edu	37	chr3	193854476	193854478	+	In_Frame_Del	DEL	TGA	TGA	-													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tctgagccagctgaaaacacTgattttggatgctctgaaga							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr3:193854476_193854478delTGA	uc003ftq.1	+	2	415_417	c.179_181delTGA	c.(178-183)CTGATT>CTT	p.I61del	HES1_uc011bst.1_In_Frame_Del_p.I61del	NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	61	Helix-loop-helix motif.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		CTGAAAACACTGATTTTGGATGC	0.389																		23	48	---	---								-	193854478	TGA	-	193854476	7	5	118	1	0	1	0	1	0	0	0	0	7065	1580	55	0	185	0	HES1	3	193854476	In_Frame_Del	DEL	TGA	TCGA-GV-A3QF-01A-31D-A22Z-08	4505169	193854476	4167954	62	35613										
SLC34A2	10568	broad.mit.edu	37	chr4	25677925	25677925	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcttcttcctgatcccgctgAcggtgtttggcctctcgctg	10	14	3	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:25677925A>T	uc003grr.2	+	13	1708	c.1627A>T	c.(1627-1629)ACG>TCG	p.T543S	SLC34A2_uc003grs.2_Missense_Mutation_p.T542S|SLC34A2_uc010iev.2_Missense_Mutation_p.T542S	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	543	Helical; Name=M7; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GATCCCGCTGACGGTGTTTGG	0.607													0	0	0	0.01441	0	48	73										T	25677925	A	T	25677925	3	4	118	1	0	0	0	0	1	0	0	0	14568	275	10	5	1673	5	SLC34A2	4	25677925	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08		25677925	165476351	63	35614										
TMPRSS11B	132724	broad.mit.edu	37	chr4	69101967	69101967	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agaaatatgaaaatcaccttGataatagtaagtcttctctg	6	6	3	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:69101967G>T	uc003hdw.3	-	3	278	c.142C>A	c.(142-144)CAA>AAA	p.Q48K		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	48	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AAATCACCTTGATAATAGTAA	0.328													1	0	2.56e-06	0.009096	2.68944e-06	3	18										T	69101967	G	T	69101967	3	4	118	1	0	0	0	0	1	0	0	0	16237	1299	45	3	1140	3	TMPRSS11B	4	69101967	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	43424042	69101967	122052309	64	35615										
ANK2	287	broad.mit.edu	37	chr4	114170923	114170923	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tttaattcttttggcaggatGggttgacaccacttcactgt	9	8	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:114170923G>A	uc003ibe.3	+	10	995	c.895G>A	c.(895-897)GGG>AGG	p.G299R	ANK2_uc003ibd.3_Missense_Mutation_p.G278R|ANK2_uc003ibf.3_Missense_Mutation_p.G299R|ANK2_uc003ibc.2_Missense_Mutation_p.G275R|ANK2_uc011cgb.1_Missense_Mutation_p.G314R	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	299	ANK 9.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTGGCAGGATGGGTTGACACC	0.458													0	0	0	0.001168	0	5	22										A	114170923	G	A	114170923	3	1	118	1	0	0	0	0	1	0	0	0	621	1348	47	2	958	2	ANK2	4	114170923	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	45068956	114170923	76983353	65	35616										
FGA	2243	broad.mit.edu	37	chr4	155508016	155508016	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cttcagatctacttcacgagCtaaagccctactgcatgacc	6	14	3	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:155508016C>A	uc003iod.1	-	5	623	c.565G>T	c.(565-567)GCT>TCT	p.A189S	FGA_uc003ioe.1_Missense_Mutation_p.A189S|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	189	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ACTTCACGAGCTAAAGCCCTA	0.418													1	0	0.00198382	0.001984	0.00203832	6	75										A	155508016	C	A	155508016	3	1	118	1	0	0	0	0	1	0	0	0	5830	797	28	4	2087	4	FGA	4	155508016	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	41337093	155508016	35646260	66	35617										
GUCY1A3	2982	broad.mit.edu	37	chr4	156631990	156631990	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcataaaggcagctgctcacGtattatatgaaacggaagtg	10	7	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:156631990G>A	uc003iov.2	+	7	1209	c.673G>A	c.(673-675)GTA>ATA	p.V225I	GUCY1A3_uc003iou.2_Missense_Mutation_p.V225I|GUCY1A3_uc010iqc.2_Missense_Mutation_p.V225I|GUCY1A3_uc003iow.2_Missense_Mutation_p.V225I|GUCY1A3_uc010iqd.2_Missense_Mutation_p.V224I|GUCY1A3_uc003iox.2_Missense_Mutation_p.V225I|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.V225I|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.V225I	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	225					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		AGCTGCTCACGTATTATATGA	0.448													0	0	0	0.00632	0	29	74										A	156631990	G	A	156631990	3	1	118	1	0	0	0	0	1	0	0	0	6894	1145	40	2	687	2	GUCY1A3	4	156631990	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	1123974	156631990	34522286	67	35618										
HMGB2	3148	broad.mit.edu	37	chr4	174253977	174253977	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aagatgacactgtaccttttCatatttctcctttagcttag	5	9	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr4:174253977C>T	uc011ckc.1	-	3	586	c.466G>A	c.(466-468)GAA>AAA	p.E156K	HMGB2_uc003ita.3_Missense_Mutation_p.E156K|HMGB2_uc003itb.2_Missense_Mutation_p.E156K|HMGB2_uc003itc.2_3'UTR	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	156	HMG box 2.				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TGTACCTTTTCATATTTCTCC	0.363													0	0	0	0.01441	0	85	116										T	174253977	C	T	174253977	3	4	118	1	0	0	0	0	1	0	0	0	7226	835	29	1	171	1	HMGB2	4	174253977	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	17621987	174253977	16900299	68	35619										
NPR3	4883	broad.mit.edu	37	chr5	32780872	32780872	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atgccaacggagaccgatatGgggatttctctgtgattgcc	12	9	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:32780872G>A	uc003jhv.2	+	5	1458	c.1240G>A	c.(1240-1242)GGG>AGG	p.G414R	NPR3_uc010iuo.2_Missense_Mutation_p.G198R|NPR3_uc011cnz.1_Missense_Mutation_p.G198R|NPR3_uc003jhu.2_Missense_Mutation_p.G414R	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	414	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	AGACCGATATGGGGATTTCTC	0.547													0	0	0	0.01441	0	70	148										A	32780872	G	A	32780872	3	1	118	1	0	0	0	0	1	0	0	0	10596	1348	47	2	1258	2	NPR3	5	32780872	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08		32780872	148134388	69	35620										
BDP1	55814	broad.mit.edu	37	chr5	70761989	70761989	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gaagagacagatgatgggccAttactggttcctcgagtaaa	12	7	0	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:70761989A>G	uc003kbp.1	+	5	989	c.726A>G	c.(724-726)CCA>CCG	p.P242P	BDP1_uc003kbn.1_Silent_p.P242P|BDP1_uc003kbo.2_Silent_p.P242P	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	242	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ATGATGGGCCATTACTGGTTC	0.368													0	0	0	0.009718	0	41	53										G	70761989	A	G	70761989	2	3	118	1	0	0	0	0	0	0	0	1	1395	204	8	5		5	BDP1	5	70761989	Silent	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	37981117	70761989	110153271	70	35621										
ZNF608	57507	broad.mit.edu	37	chr5	123983756	123983756	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttggtgtagcctgaacaacaGttgttgtgagggagggcagt	16	5	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:123983756G>C	uc003ktq.1	-	4	2444	c.2321C>G	c.(2320-2322)ACT>AGT	p.T774S	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Missense_Mutation_p.T774S|ZNF608_uc003ktt.1_Missense_Mutation_p.T774S	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	774						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTGAACAACAGTTGTTGTGAG	0.552													0	0	0	0.000602	0	5	81										C	123983756	G	C	123983756	3	2	118	1	0	0	0	0	1	0	0	0	18031	1029	36	4	2241	4	ZNF608	5	123983756	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	53221767	123983756	56931504	71	35622										
GRM6	2916	broad.mit.edu	37	chr5	178416401	178416401	+	Missense_Mutation	SNP	C	C	T													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcgagtcatgaagtactggtCaaatcctacagacagggaag							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:178416401C>T	uc003mjr.2	-	5	1197	c.1018G>A	c.(1018-1020)GAC>AAC	p.D340N	GRM6_uc010jla.1_5'UTR|GRM6_uc003mjs.1_5'UTR	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	340	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AAGTACTGGTCAAATCCTACA	0.527													0	0	0	0.013537	0	13	68										T	178416401	C	T	178416401	3	4	118	1	0	0	0	0	1	0	0	0	6801	826	29	1	1639	1	GRM6	5	178416401	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	54432645	178416401	2498859	72	35623	187	2								
GRM6	2916	broad.mit.edu	37	chr5	178416406	178416406	+	Missense_Mutation	SNP	C	C	T													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcatgaagtactggtcaaatCctacagacagggaagaaggg							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr5:178416406C>T	uc003mjr.2	-	5	1192	c.1013G>A	c.(1012-1014)GGA>GAA	p.G338E	GRM6_uc010jla.1_5'UTR|GRM6_uc003mjs.1_5'UTR	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	338	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CTGGTCAAATCCTACAGACAG	0.532													0	0	0	0.008291	0	11	66										T	178416406	C	T	178416406	3	4	118	1	0	0	0	0	1	0	0	0	6801	869	30	1	1644	1	GRM6	5	178416406	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	5	178416406	2498854	73	35624	187	2								
TFAP2A	7020	broad.mit.edu	37	chr6	10410399	10410399	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggtcgttgacgtgggagtaaGgatcttgcgactgggggtag	19	5	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:10410399G>A	uc003myr.2	-	2	467	c.215C>T	c.(214-216)CCT>CTT	p.P72L	TFAP2A_uc003myq.2_Missense_Mutation_p.P66L|TFAP2A_uc003mys.2_Intron|TFAP2A_uc011dih.1_Missense_Mutation_p.P72L|TFAP2A_uc003myt.2_Missense_Mutation_p.P68L|TFAP2A_uc003myu.1_Missense_Mutation_p.P72L|TFAP2A_uc003myv.1_Missense_Mutation_p.P58L|TFAP2A_uc011dii.1_Missense_Mutation_p.P68L|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	72	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding	p.P66R(1)		ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				GTGGGAGTAAGGATCTTGCGA	0.672													0	0	0	0.004482	0	8	63										A	10410399	G	A	10410399	3	1	118	1	0	0	0	0	1	0	0	0	15784	1000	35	2	1122	2	TFAP2A	6	10410399	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08		10410399	160704668	74	35625										
OR2W1	26692	broad.mit.edu	37	chr6	29012935	29012935	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ataaaaccatgtaaagaactAtaattgctttggtccatagt	6	6	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:29012935A>G	uc003nlw.2	-	1	18	c.18T>C	c.(16-18)TAT>TAC	p.Y6Y		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTAAAGAACTATAATTGCTTT	0.284													0	0	0	0.00632	0	28	51										G	29012935	A	G	29012935	2	3	118	1	0	0	0	0	0	0	0	1	11032	456	16	5		5	OR2W1	6	29012935	Silent	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	18602536	29012935	142102132	75	35626										
CCHCR1	54535	broad.mit.edu	37	chr6	31110378	31110378	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ctgtcagctgcttagctgctCatctggggattggagctgga	14	9	3	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:31110378C>T	uc003nsr.3	-	18	2463	c.2340G>A	c.(2338-2340)ATG>ATA	p.M780I	CCHCR1_uc011dne.1_Missense_Mutation_p.M766I|CCHCR1_uc003nsq.3_Missense_Mutation_p.M833I|CCHCR1_uc003nsp.3_Missense_Mutation_p.M869I	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	780					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1						CTTAGCTGCTCATCTGGGGAT	0.577													0	0	0	0.004007	0	17	36										T	31110378	C	T	31110378	3	4	118	1	0	0	0	0	1	0	0	0	2877	826	29	1	12	1	CCHCR1	6	31110378	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	2097443	31110378	140004689	76	35627										
PGC	5225	broad.mit.edu	37	chr6	41712175	41712175	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tagacagagggcacccacaaGttggaggagccggtgtcaaa	14	9	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:41712175G>A	uc003ora.1	-	3	337	c.288C>T	c.(286-288)AAC>AAT	p.N96N		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	96					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GCACCCACAAGTTGGAGGAGC	0.612													0	0	0	0.014323	0	21	50										A	41712175	G	A	41712175	2	1	118	1	0	0	0	0	0	0	0	1	11785	1020	36	2		2	PGC	6	41712175	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	10601797	41712175	129402892	77	35628										
TRERF1	55809	broad.mit.edu	37	chr6	42203985	42203985	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cagatgaaggagcctgagggCtggcccagggcctgcagggg	19	10	0	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:42203985C>A	uc003osd.2	-	16	3587	c.3024G>T	c.(3022-3024)CAG>CAT	p.Q1008H	TRERF1_uc011duq.1_Missense_Mutation_p.Q925H|TRERF1_uc003osb.2_Missense_Mutation_p.Q764H|TRERF1_uc003osc.2_Missense_Mutation_p.Q764H|TRERF1_uc003ose.2_Missense_Mutation_p.Q1028H	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1008	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGCCTGAGGGCTGGCCCAGGG	0.627													1	0	2.0095e-06	0.001984	2.13509e-06	6	14										A	42203985	C	A	42203985	3	1	118	1	0	0	0	0	1	0	0	0	16472	796	28	4	590	4	TRERF1	6	42203985	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	491810	42203985	128911082	78	35629										
DPPA5	340168	broad.mit.edu	37	chr6	74063929	74063929	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cccacggcgggatatgtctaCgtgccgggagagttcccatc	13	13	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:74063929C>T	uc003pgs.1	-	1	25	c.20G>A	c.(19-21)CGT>CAT	p.R7H		NM_001025290	NP_001020461	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	7					multicellular organismal development	cytoplasm	RNA binding				0						GATATGTCTACGTGCCGGGAG	0.572													0	0	0	0.009096	0	4	29										T	74063929	C	T	74063929	3	4	118	1	0	0	0	0	1	0	0	0	4737	536	19	2	342	2	DPPA5	6	74063929	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	31859944	74063929	97051138	79	35630										
TPBG	7162	broad.mit.edu	37	chr6	83075858	83075858	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	acatcagagatgcctgcaggGatcacatggaagggtatcat	12	8	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:83075858G>T	uc003pjn.3	+	3	2116	c.1180G>T	c.(1180-1182)GAT>TAT	p.D394Y	TPBG_uc010kbj.2_Missense_Mutation_p.D394Y|TPBG_uc003pjo.2_Missense_Mutation_p.D394Y	NM_006670	NP_006661	Q13641	TPBG_HUMAN	trophoblast glycoprotein precursor	394	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(1)	1		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		TGCCTGCAGGGATCACATGGA	0.423													1	0	1.50039e-11	0.012319	1.68008e-11	19	63										T	83075858	G	T	83075858	3	4	118	1	0	0	0	0	1	0	0	0	16391	1174	41	3	1182	3	TPBG	6	83075858	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	9011929	83075858	88039209	80	35631										
C6orf97	80129	broad.mit.edu	37	chr6	151907137	151907137	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aaagcagagaatatgttggaGactcttcagggtcagctgac	12	7	3	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr6:151907137G>A	uc003qol.2	+	7	1295	c.1206G>A	c.(1204-1206)GAG>GAA	p.E402E		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	402	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		ATATGTTGGAGACTCTTCAGG	0.473													0	0	0	0.000602	0	4	13										A	151907137	G	A	151907137	2	1	118	1	0	0	0	0	0	0	0	1	2374	933	33	1		1	C6orf97	6	151907137	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	68831279	151907137	19207930	81	35632										
ETV1	2115	broad.mit.edu	37	chr7	13971355	13971355	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aggaaaggagttacagggttCagaaagctggcggcgaaatc	15	6	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:13971355C>G	uc011jxq.1	-	9	1313	c.574G>C	c.(574-576)GAA>CAA	p.E192Q	ETV1_uc011jxn.1_Missense_Mutation_p.E152Q|ETV1_uc011jxo.1_Missense_Mutation_p.E89Q|ETV1_uc011jxp.1_Missense_Mutation_p.E134Q|ETV1_uc003ssw.3_Missense_Mutation_p.E192Q|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.E174Q|ETV1_uc011jxs.1_Missense_Mutation_p.E174Q|ETV1_uc010ktv.2_Missense_Mutation_p.E61Q	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	192					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						TTACAGGGTTCAGAAAGCTGG	0.468			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								0	0	0	0.004482	0	6	34										G	13971355	C	G	13971355	3	3	118	1	0	0	0	0	1	0	0	0	5277	835	29	1	883	1	ETV1	7	13971355	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		13971355	145167308	82	35633										
EVX1	2128	broad.mit.edu	37	chr7	27282715	27282715	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cttggcactctggttggcaaGagagtctcaaatttgtccga	11	9	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:27282715G>C	uc003szd.1	+	1	552	c.66G>C	c.(64-66)AAG>AAC	p.K22N	EVX1_uc011jzn.1_5'UTR|EVX1_uc010kuy.1_Missense_Mutation_p.K22N	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	22						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TGGTTGGCAAGAGAGTCTCAA	0.652													0	0	0	0.001168	0	4	8										C	27282715	G	C	27282715	3	2	118	1	0	0	0	0	1	0	0	0	5294	933	33	1	68	1	EVX1	7	27282715	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	13311360	27282715	131855948	83	35634										
CCDC129	223075	broad.mit.edu	37	chr7	31683174	31683174	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gtggccttggggactggtccCagaggaacatctttagaatg	14	8	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:31683174C>T	uc003tcj.1	+	11	3183	c.2190C>T	c.(2188-2190)CCC>CCT	p.P730P	CCDC129_uc011kad.1_Silent_p.P740P|CCDC129_uc003tci.1_Silent_p.P581P|CCDC129_uc011kae.1_Silent_p.P756P|CCDC129_uc003tck.1_Silent_p.P638P	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	730											0						GGACTGGTCCCAGAGGAACAT	0.507													0	0	0	0.004007	0	16	50										T	31683174	C	T	31683174	2	4	118	1	0	0	0	0	0	0	0	1	2764	581	21	2		2	CCDC129	7	31683174	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	4400459	31683174	127455489	84	35635										
TXNDC3	51314	broad.mit.edu	37	chr7	37904018	37904018	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aaaaagttctagaaattaaaAgaaaagtaagtaatattttc	5	2	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:37904018A>G	uc003tfn.2	+	9	895	c.523A>G	c.(523-525)AGA>GGA	p.R175G		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	175	NDK 1.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						AGAAATTAAAAGAAAAGTAAG	0.274									Kartagener_syndrome				0	0	0	0.004672	0	3	12										G	37904018	A	G	37904018	3	3	118	1	0	0	0	0	1	0	0	0	16795	64	3	5	549	5	TXNDC3	7	37904018	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	6220844	37904018	121234645	85	35636										
ZMIZ2	83637	broad.mit.edu	37	chr7	44795867	44795867	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caatgaactccatgaaccccAtgaaacctgccctgccccct	5	18	0	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:44795867A>G	uc003tlr.2	+	2	142	c.19A>G	c.(19-21)ATG>GTG	p.M7V	ZMIZ2_uc003tlq.2_Missense_Mutation_p.M7V|ZMIZ2_uc003tls.2_Missense_Mutation_p.M7V	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	7					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CATGAACCCCATGAAACCTGC	0.607													0	0	0	0.008871	0	19	35										G	44795867	A	G	44795867	3	3	118	1	0	0	0	0	1	0	0	0	17694	217	8	5	21	5	ZMIZ2	7	44795867	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	6891849	44795867	114342796	86	35637										
ADCY1	107	broad.mit.edu	37	chr7	45726145	45726145	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttcttcctcatcttcccccaGgggtggtgccgtctccgggc	11	16	4	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:45726145G>A	uc003tne.3	+	14	2346	c.2328_splice	c.e14-1	p.G776_splice		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCTTCCCCCAGGGGTGGTGCC	0.612													0	0	0	0.001855	0	12	30										A	45726145	G	A	45726145	5	1	118	1	0	0	0	0	0	0	1	0	292	1014	35	2	2381	2	ADCY1	7	45726145	Splice_Site	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	930278	45726145	113412518	87	35638										
ZNF804B	219578	broad.mit.edu	37	chr7	88963715	88963715	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	acagaaccctgtatctcttaTggctgcaacccactgtattt	6	12	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr7:88963715T>C	uc011khi.1	+	4	1957	c.1419T>C	c.(1417-1419)TAT>TAC	p.Y473Y		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	473						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTATCTCTTATGGCTGCAACC	0.433										HNSCC(36;0.09)			0	0	0	0.003954	0	25	59										C	88963715	T	C	88963715	2	2	118	1	0	0	0	0	0	0	0	1	18168	1471	51	5		5	ZNF804B	7	88963715	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	43237570	88963715	70174948	88	35639										
CSMD1	64478	broad.mit.edu	37	chr8	2824091	2824091	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccatgatgtctgcttactaaCttgtgcagtcgggagcagtg	12	9	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:2824091C>G	uc011kwk.1	-	58	9493	c.9103_splice	c.e58+1	p.I3035_splice	CSMD1_uc011kwj.1_Splice_Site_p.I2364_splice|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTTACTAACTTGTGCAGTC	0.443													0	0	0	0.000602	0	5	12										G	2824091	C	G	2824091	5	3	118	1	0	0	0	0	0	0	1	0	3944	579	20	4	1645	4	CSMD1	8	2824091	Splice_Site	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		2824091	143539931	89	35640										
EBF2	64641	broad.mit.edu	37	chr8	25718601	25718601	+	Frame_Shift_Del	DEL	C	C	-													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tgttgactctgagatgctgaCcccaagctggctgccatagg							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:25718601delC	uc003xes.1	-	13	1323	c.1306delG	c.(1306-1308)GTCfs	p.V436fs	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	436					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GAGATGCTGACCCCAAGCTGG	0.493																		53	63	---	---								-	25718601	C	-	25718601	7	5	118	1	0	1	0	1	0	0	0	0	4881	507	18	0	437	0	EBF2	8	25718601	Frame_Shift_Del	DEL	C	TCGA-GV-A3QF-01A-31D-A22Z-08	22894510	25718601	120645421	90	35641										
ZFHX4	79776	broad.mit.edu	37	chr8	77767234	77767234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caaagtcggccttagaaagcCacattcgctctcggcactgg	10	13	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:77767234C>T	uc003yav.2	+	10	8329	c.7942C>T	c.(7942-7944)CAC>TAC	p.H2648Y	ZFHX4_uc003yau.1_Missense_Mutation_p.H2693Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.H2648Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2648	C2H2-type 17.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTTAGAAAGCCACATTCGCTC	0.542										HNSCC(33;0.089)			0	0	0	0.008291	0	9	53										T	77767234	C	T	77767234	3	4	118	1	0	0	0	0	1	0	0	0	17632	594	21	2	8111	2	ZFHX4	8	77767234	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	52048633	77767234	68596788	91	35642										
TRHR	7201	broad.mit.edu	37	chr8	110131363	110131363	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gtggttgtcaactcatttctCtccagtcctttccaagaaaa	6	11	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:110131363C>T	uc003ymz.3	+	2	892	c.876C>T	c.(874-876)CTC>CTT	p.L292L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	292	Extracellular (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ACTCATTTCTCTCCAGTCCTT	0.428													0	0	0	0.01441	0	118	206										T	110131363	C	T	110131363	2	4	118	1	0	0	0	0	0	0	0	1	16477	900	32	1		1	TRHR	8	110131363	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	32364129	110131363	36232659	92	35643										
PKHD1L1	93035	broad.mit.edu	37	chr8	110439238	110439238	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tctgtgagtgcaggcctcccCgctgctgtgtcagctgcaga	13	13	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:110439238C>T	uc003yne.2	+	25	2957	c.2853C>T	c.(2851-2853)CCC>CCT	p.P951P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	951	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAGGCCTCCCCGCTGCTGTGT	0.438										HNSCC(38;0.096)			0	0	0	0.004007	0	17	85										T	110439238	C	T	110439238	2	4	118	1	0	0	0	0	0	0	0	1	11972	639	23	2		2	PKHD1L1	8	110439238	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	307875	110439238	35924784	93	35644										
NOV	4856	broad.mit.edu	37	chr8	120428805	120428805	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cagagcacgagcttttgtctCcgaaagcagtgcctttgcct	10	12	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:120428805C>T	uc003yoq.2	+	1	254	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	11					regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTTTTGTCTCCGAAAGCAGT	0.542											OREG0018940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	13										T	120428805	C	T	120428805	2	4	118	1	0	0	0	0	0	0	0	1	10553	842	30	1		1	NOV	8	120428805	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	9989567	120428805	25935217	94	35645										
FER1L6	654463	broad.mit.edu	37	chr8	125072849	125072849	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcctctctgtggatcggcctCaggctctcattgagtgcgga	12	12	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:125072849C>G	uc003yqw.2	+	24	3252	c.3046C>G	c.(3046-3048)CAG>GAG	p.Q1016E	uc003yqy.1_RNA	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1016	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GGATCGGCCTCAGGCTCTCAT	0.542													0	0	0	0.00333	0	25	39										G	125072849	C	G	125072849	3	3	118	1	0	0	0	0	1	0	0	0	5815	827	29	1	3136	1	FER1L6	8	125072849	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	4644044	125072849	21291173	95	35646										
PHF20L1	51105	broad.mit.edu	37	chr8	133854841	133854842	+	Frame_Shift_Ins	INS	-	-	A													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aaataatagctggggtggagINSaaaaaaatagctcaagacac							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr8:133854841_133854842insA	uc003ytt.2	+	19	2794_2795	c.2469_2470insA	c.(2467-2472)GAGAAAfs	p.E823fs	PHF20L1_uc011lja.1_Frame_Shift_Ins_p.E797fs	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	823_824							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			CTGGGGTGGAGAAAAAAATAGC	0.381																		12	26	---	---								A	133854842	-	A	133854841	7	5	118	1	0	1	1	0	0	0	0	0	11832	933	33	0	2635	0	PHF20L1	8	133854841	Frame_Shift_Ins	INS	-	TCGA-GV-A3QF-01A-31D-A22Z-08	8781992	133854841	12509181	96	35647										
DOCK8	81704	broad.mit.edu	37	chr9	429743	429743	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gaggaggtggaacagtgtttCgacctatgtcaccaagtcct	12	9	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:429743C>T	uc003zgf.2	+	36	4627	c.4515C>T	c.(4513-4515)TTC>TTT	p.F1505F	DOCK8_uc010mgu.2_Silent_p.F807F|DOCK8_uc010mgv.2_Silent_p.F1405F|DOCK8_uc003zgk.2_Silent_p.F963F	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1505	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		AACAGTGTTTCGACCTATGTC	0.502													0	0	0	0.01441	0	60	18										T	429743	C	T	429743	2	4	118	1	0	0	0	0	0	0	0	1	4693	883	31	1		1	DOCK8	9	429743	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		429743	140783688	97	35648										
RLN1	6013	broad.mit.edu	37	chr9	5339616	5339616	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tgctcatgccgcaaatggcaAtctgcgcgcgaactaattcg	10	12	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:5339616A>T	uc003zjb.1	-	1	258	c.131T>A	c.(130-132)ATT>AAT	p.I44N		NM_006911	NP_008842	P04808	REL1_HUMAN	relaxin 1 preproprotein	44					female pregnancy|signal transduction	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.02)|Lung(218;0.0984)		GCAAATGGCAATCTGCGCGCG	0.527													0	0	0	0.009096	0	4	56										T	5339616	A	T	5339616	3	4	118	1	0	0	0	0	1	0	0	0	13391	101	4	5	434	5	RLN1	9	5339616	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	4909873	5339616	135873815	98	35649										
MPDZ	8777	broad.mit.edu	37	chr9	13205963	13205963	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caaatctgcatcttttgtgaCgtcttcccttgacatgagct	7	11	3	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:13205963C>A	uc010mia.1	-	10	1483	c.1426G>T	c.(1426-1428)GTC>TTC	p.V476F	MPDZ_uc010mhy.2_Missense_Mutation_p.V476F|MPDZ_uc010mhz.2_Missense_Mutation_p.V476F|MPDZ_uc011lmn.1_Missense_Mutation_p.V476F|MPDZ_uc003zlb.3_Missense_Mutation_p.V476F	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	476					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TCTTTTGTGACGTCTTCCCTT	0.418													1	0	2.56e-06	0.009096	2.68944e-06	4	39										A	13205963	C	A	13205963	3	1	118	1	0	0	0	0	1	0	0	0	9722	536	19	4	4843	4	MPDZ	9	13205963	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	7866347	13205963	128007468	99	35650										
ARID3C	138715	broad.mit.edu	37	chr9	34622477	34622477	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttctcccgtgtaggtcccagTgccaggcccacaggcagtgc	12	15	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:34622477T>C	uc011lon.1	-	5	915	c.915A>G	c.(913-915)GCA>GCG	p.A305A	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	305	REKLES.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TAGGTCCCAGTGCCAGGCCCA	0.582													0	0	0	0.010771	0	44	34										C	34622477	T	C	34622477	2	2	118	1	0	0	0	0	0	0	0	1	918	1683	59	5		5	ARID3C	9	34622477	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	21416514	34622477	106590954	100	35651										
PTPN3	5774	broad.mit.edu	37	chr9	112151578	112151590	+	Frame_Shift_Del	DEL	GCCAAAACTGTGC	GCCAAAACTGTGC	-													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cttctgatcccagacaacctGccaaaactgtgcacaggtat							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:112151578_112151590delGCCAAAACTGTGC	uc004bed.2	-	22	2288_2300	c.2176_2188delGCACAGTTTTGGC	c.(2176-2190)GCACAGTTTTGGCAGfs	p.A726fs	PTPN3_uc004beb.2_Frame_Shift_Del_p.A595fs|PTPN3_uc004bec.2_Frame_Shift_Del_p.A550fs|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Frame_Shift_Del_p.A681fs|PTPN3_uc011lwh.1_Frame_Shift_Del_p.A572fs|PTPN3_uc011lwd.1_Frame_Shift_Del_p.A194fs|PTPN3_uc011lwe.1_Frame_Shift_Del_p.A439fs|PTPN3_uc011lwf.1_Frame_Shift_Del_p.A394fs	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	726_730	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CAGACAACCTGCCAAAACTGTGCACAGGTATGC	0.465																		16	21	---	---								-	112151590	GCCAAAACTGTGC	-	112151578	7	5	118	1	0	1	0	1	0	0	0	0	12789	1328	46	0	573	0	PTPN3	9	112151578	Frame_Shift_Del	DEL	GCCAAAACTGTGC	TCGA-GV-A3QF-01A-31D-A22Z-08	77529101	112151578	29061853	101	35652										
DFNB31	25861	broad.mit.edu	37	chr9	117186682	117186682	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cacagagacgctgccaccacGgtactcatccaggtagtagg	11	13	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:117186682G>C	uc004biz.3	-	6	1997	c.1348C>G	c.(1348-1350)CGT>GGT	p.R450G	DFNB31_uc004bix.2_Missense_Mutation_p.R99G|DFNB31_uc004biy.3_Missense_Mutation_p.R67G|DFNB31_uc004bja.3_Missense_Mutation_p.R450G	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	450					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTGCCACCACGGTACTCATCC	0.632													0	0	0	0.010729	0	12	56										C	117186682	G	C	117186682	3	2	118	1	0	0	0	0	1	0	0	0	4455	1116	39	4	1403	4	DFNB31	9	117186682	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	5035104	117186682	24026749	102	35653										
TSC1	7248	broad.mit.edu	37	chr9	135777087	135777087	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ctgcagtcctccagcttcgtCtgcccaaagagacgtggaca	10	14	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:135777087C>A	uc004cca.2	-	19	2626	c.2392_splice	c.e19-1	p.T798_splice	TSC1_uc004ccb.3_Splice_Site_p.T797_splice|TSC1_uc011mcq.1_Splice_Site_p.T747_splice|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1						activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CCAGCTTCGTCTGCCCAAAGA	0.547			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis		OREG0019577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	7.73544e-29	0.01441	9.21355e-29	68	42										A	135777087	C	A	135777087	5	1	118	1	0	0	0	0	0	0	1	0	16602	927	32	3	1123	3	TSC1	9	135777087	Splice_Site	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	18590405	135777087	5436344	103	35654										
SNAPC4	6621	broad.mit.edu	37	chr9	139276292	139276292	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ataccttgagtctgcactacGgcgggtctctgggaagcctg	13	11	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr9:139276292G>A	uc004chh.2	-	17	2310	c.2301C>T	c.(2299-2301)GCC>GCT	p.A767A		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	767					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TCTGCACTACGGCGGGTCTCT	0.642													0	0	0	0.006214	0	9	36										A	139276292	G	A	139276292	2	1	118	1	0	0	0	0	0	0	0	1	14837	1103	39	2		2	SNAPC4	9	139276292	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	3499205	139276292	1937139	104	35655										
SLC39A12	221074	broad.mit.edu	37	chr10	18292239	18292239	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccatgtgttcaagactggatCttcacagtcactgctgggat	10	10	4	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr10:18292239C>A	uc001ipo.2	+	12	2172	c.1899C>A	c.(1897-1899)ATC>ATA	p.I633I	SLC39A12_uc001ipn.2_Silent_p.I596I|SLC39A12_uc001ipp.2_Silent_p.I632I|SLC39A12_uc010qck.1_Silent_p.I499I|uc001ipq.1_RNA	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	633	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						AAGACTGGATCTTCACAGTCA	0.393													1	0	1.13049e-35	0.01441	1.35514e-35	93	112										A	18292239	C	A	18292239	2	1	118	1	0	0	0	0	0	0	0	1	14615	903	32	3		3	SLC39A12	10	18292239	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		18292239	117242508	105	35656										
WAPAL	23063	broad.mit.edu	37	chr10	88259960	88259960	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gtccaactgtccctctaaaaCtggtcccacaacttacaccc	4	17	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr10:88259960C>A	uc001kdo.2	-	3	1482	c.1040G>T	c.(1039-1041)AGT>ATT	p.S347I	WAPAL_uc001kdn.2_Missense_Mutation_p.S390I|WAPAL_uc009xsw.2_Missense_Mutation_p.S347I	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	347	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						CCCTCTAAAACTGGTCCCACA	0.463													1	0	7.88023e-25	0.01441	9.21002e-25	45	48										A	88259960	C	A	88259960	3	1	118	1	0	0	0	0	1	0	0	0	17245	565	20	4	2600	4	WAPAL	10	88259960	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	69967721	88259960	47274787	106	35657										
OR51M1	390059	broad.mit.edu	37	chr11	5410829	5410829	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	attaagaccaaccctcgtctGcacacacccatgtactatct	4	15	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:5410829G>T	uc010qzc.1	+	1	201	c.201G>T	c.(199-201)CTG>CTT	p.L67L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	67						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCCTCGTCTGCACACACCCA	0.463													1	0	1.33834e-09	0.007413	1.46356e-09	20	75										T	5410829	G	T	5410829	2	4	118	1	0	0	0	0	0	0	0	1	11103	1306	46	4		4	OR51M1	11	5410829	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08		5410829	129595687	107	35658										
DBX1	120237	broad.mit.edu	37	chr11	20178183	20178183	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agatcaggggctccgggggaCgcacgggggcggggagtgga	23	8	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:20178183C>T	uc001mpw.1	-	4	726	c.726G>A	c.(724-726)GCG>GCA	p.A242A		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCCGGGGGACGCACGGGGGC	0.622													0	0	0	0.007413	0	19	18										T	20178183	C	T	20178183	2	4	118	1	0	0	0	0	0	0	0	1	4259	523	19	2		2	DBX1	11	20178183	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	14767354	20178183	114828333	108	35659										
OR4P4	81300	broad.mit.edu	37	chr11	55406051	55406051	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ctccgacctttgctacacatCcacagtgacccccaaattaa	4	16	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:55406051C>T	uc010rij.1	+	1	218	c.218C>T	c.(217-219)TCC>TTC	p.S73F		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TGCTACACATCCACAGTGACC	0.398													0	0	0	0.01441	0	49	99										T	55406051	C	T	55406051	3	4	118	1	0	0	0	0	1	0	0	0	11080	855	30	1	220	1	OR4P4	11	55406051	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	35227868	55406051	79600465	109	35660										
OR5W2	390148	broad.mit.edu	37	chr11	55681672	55681672	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atgttgactgtatagagcagGgggttgatgatggccttgta	15	4	0	4			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:55681672G>T	uc010rir.1	-	1	387	c.387C>A	c.(385-387)CCC>CCA	p.P129P		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TATAGAGCAGGGGGTTGATGA	0.463													1	0	2.20262e-25	0.013726	2.5905e-25	34	47										T	55681672	G	T	55681672	2	4	118	1	0	0	0	0	0	0	0	1	11185	1219	43	4		4	OR5W2	11	55681672	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	275621	55681672	79324844	110	35661										
MPEG1	219972	broad.mit.edu	37	chr11	58979792	58979792	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	catcctcgtctggttgttctCtagacggtcagagatgtcaa	10	10	4	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:58979792C>G	uc001nnu.3	-	1	703	c.547G>C	c.(547-549)GAG>CAG	p.E183Q		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	183	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				TGGTTGTTCTCTAGACGGTCA	0.507													0	0	0	0.004289	0	36	90										G	58979792	C	G	58979792	3	3	118	1	0	0	0	0	1	0	0	0	9723	922	32	1	1607	1	MPEG1	11	58979792	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	3298120	58979792	76026724	111	35662										
RASGRP2	10235	broad.mit.edu	37	chr11	64494818	64494818	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atcctccaccgtctgtacctCctcctcacggatctctgctg	6	18	3	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:64494818C>A	uc009ypu.2	-	16	2013	c.1786G>T	c.(1786-1788)GAG>TAG	p.E596*	RASGRP2_uc001oat.2_Nonsense_Mutation_p.E499*|RASGRP2_uc001oau.2_Nonsense_Mutation_p.E452*|RASGRP2_uc009ypv.2_Nonsense_Mutation_p.E596*|RASGRP2_uc009ypw.2_Nonsense_Mutation_p.E596*	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	596					platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						GTCTGTACCTCCTCCTCACGG	0.597													1	0	3.09899e-07	0.004482	3.36925e-07	9	49										A	64494818	C	A	64494818	4	1	118	1	0	0	0	0	0	1	0	0	13075	864	30	3	47	3	RASGRP2	11	64494818	Nonsense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	5515026	64494818	70511698	112	35663										
PYGM	5837	broad.mit.edu	37	chr11	64519519	64519519	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tttgtattccctctctaggtAggcagcaaacttcaacttgt	7	10	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:64519519A>G	uc001oax.3	-	14	2462	c.1645T>C	c.(1645-1647)TAC>CAC	p.Y549H	PYGM_uc001oay.3_Missense_Mutation_p.Y461H	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	549					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CTCTCTAGGTAGGCAGCAAAC	0.517													0	0	0	0.01441	0	50	118										G	64519519	A	G	64519519	3	3	118	1	0	0	0	0	1	0	0	0	12862	420	15	5	911	5	PYGM	11	64519519	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08	24701	64519519	70486997	113	35664										
PCNXL3	399909	broad.mit.edu	37	chr11	65392689	65392689	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gtcctcttctcagtcttctgTggcctcctggtggcactgtc	10	14	4	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:65392689T>C	uc001oey.2	+	17	2967	c.2967T>C	c.(2965-2967)TGT>TGC	p.C989C	PCNXL3_uc009yqn.2_5'UTR|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	989	Helical; (Potential).					integral to membrane					0						CAGTCTTCTGTGGCCTCCTGG	0.642													0	0	0	0.004482	0	7	16										C	65392689	T	C	65392689	2	2	118	1	0	0	0	0	0	0	0	1	11593	1702	59	5		5	PCNXL3	11	65392689	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	873170	65392689	69613827	114	35665										
BUD13	84811	broad.mit.edu	37	chr11	116628530	116628531	+	Missense_Mutation	DNP	CC	CC	AA													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	attcttcttgatgaagttggCcatagggtccccctctcttt							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:116628530_116628531CC>AA	uc001ppn.2	-	8	1669_1670	c.1635_1636GG>TT	c.(1633-1638)ATGGCC>ATTTCC	p.545_546MA>IS	BUD13_uc001ppo.2_Missense_Mutation_p.411_412MA>IS	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	545_546										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		ATGAAGTTGGCCATAGGGTCCC	0.45													0	0	0	0.004672	0	89	153										AA	116628531	CC	AA	116628530	3	1	118	1	0	0	0	0	1	0	0	0	1573	739	26	4	235	4	BUD13	11	116628530	Missense_Mutation	DNP	CC	TCGA-GV-A3QF-01A-31D-A22Z-08	51235841	116628530	18377986	115	35666										
OR8B2	26595	broad.mit.edu	37	chr11	124252689	124252690	+	Frame_Shift_Ins	INS	-	-	G													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggtgcaggaaagctggaggaINSgggggagtatgtcacacaag							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:124252689_124252690insG	uc010sai.1	-	1	550_551	c.550_551insC	c.(550-552)CTCfs	p.L184fs		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AAGCTGGAGGAGGGGGAGTATG	0.5																		11	57	---	---								G	124252690	-	G	124252689	7	5	118	1	0	1	1	0	0	0	0	0	11227	304	11	0	393	0	OR8B2	11	124252689	Frame_Shift_Ins	INS	-	TCGA-GV-A3QF-01A-31D-A22Z-08	7624159	124252689	10753827	116	35667										
OPCML	4978	broad.mit.edu	37	chr11	132307139	132307139	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttacagtgatttttactttcCgcacatcgggcgcagcgaca	9	11	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr11:132307139C>T	uc001qgs.2	-	4	691	c.641G>A	c.(640-642)CGG>CAG	p.R214Q	OPCML_uc001qgu.2_Missense_Mutation_p.R207Q|OPCML_uc010sck.1_Missense_Mutation_p.R214Q|OPCML_uc001qgt.2_Missense_Mutation_p.R213Q|OPCML_uc010scl.1_Missense_Mutation_p.R173Q	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	214	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TTTTACTTTCCGCACATCGGG	0.542													0	0	0	0.008871	0	16	68										T	132307139	C	T	132307139	3	4	118	1	0	0	0	0	1	0	0	0	10874	652	23	2	412	2	OPCML	11	132307139	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	8054450	132307139	2699377	117	35668										
ABCD2	225	broad.mit.edu	37	chr12	40013068	40013068	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	catagatagaaagaaaggttCttgagattagagccactgag	11	5	1	6			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:40013068C>T	uc001rmb.2	-	1	776	c.350G>A	c.(349-351)AGA>AAA	p.R117K		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	117	ABC transmembrane type-1.|Interaction with PEX19.|Helical; (Potential).				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						AAGAAAGGTTCTTGAGATTAG	0.413													0	0	0	0.012319	0	23	62										T	40013068	C	T	40013068	3	4	118	1	0	0	0	0	1	0	0	0	61	913	32	1	1912	1	ABCD2	12	40013068	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		40013068	93838827	118	35669										
SYT1	6857	broad.mit.edu	37	chr12	79842725	79842726	+	In_Frame_Ins	INS	-	-	ACA													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggtggtggtaactgttttggINSactatgacaagattggcaag							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:79842725_79842726insACA	uc001sys.2	+	12	1761_1762	c.1090_1091insACA	c.(1090-1092)GAC>GACAAC	p.364_365insN	SYT1_uc001syt.2_In_Frame_Ins_p.364_365insN|SYT1_uc001syu.2_In_Frame_Ins_p.361_362insN|SYT1_uc001syv.2_In_Frame_Ins_p.364_365insN	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	364_365	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 2.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AACTGTTTTGGACTATGACAAG	0.49																		19	98	---	---								ACA	79842726	-	ACA	79842725	7	5	118	1	0	1	1	0	0	0	0	0	15462	1174	41	0	1120	0	SYT1	12	79842725	In_Frame_Ins	INS	-	TCGA-GV-A3QF-01A-31D-A22Z-08	39829657	79842725	54009170	119	35670										
KSR2	283455	broad.mit.edu	37	chr12	117914394	117914394	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttctggatgcgcagtttgtcCtcccgcctggagaagcaaag	12	11	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:117914394C>T	uc001two.2	-	17	2425	c.2370G>A	c.(2368-2370)GAG>GAA	p.E790E		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	819	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCAGTTTGTCCTCCCGCCTGG	0.602													0	0	0	0.009096	0	3	7										T	117914394	C	T	117914394	2	4	118	1	0	0	0	0	0	0	0	1	8582	680	24	2		2	KSR2	12	117914394	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	38071669	117914394	15937501	120	35671										
CLIP1	6249	broad.mit.edu	37	chr12	122818658	122818658	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gtgtaacttatttacagtttCtatttaggataaaagttaga	7	3	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:122818658C>T	uc001ucg.1	-	13	2733	c.2627_splice	c.e13-1	p.E876_splice	CLIP1_uc001uch.1_Splice_Site_p.E865_splice|CLIP1_uc001uci.1_Splice_Site_p.E830_splice|CLIP1_uc001ucj.1_Splice_Site_p.E451_splice	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a						mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTTACAGTTTCTATTTAGGAT	0.343													0	0	0	0.000602	0	5	17										T	122818658	C	T	122818658	5	4	118	1	0	0	0	0	0	0	1	0	3532	927	32	1	1742	1	CLIP1	12	122818658	Splice_Site	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	4904264	122818658	11033237	121	35672										
DNAH10	196385	broad.mit.edu	37	chr12	124265822	124265822	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agaaatttgcaagtaatattCaaagaaccatgcagcaactt	6	7	1	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:124265822C>G	uc001uft.3	+	6	659	c.634C>G	c.(634-636)CAA>GAA	p.Q212E		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	212	Stem (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAGTAATATTCAAAGAACCAT	0.313													0	0	0	0.01441	0	68	100										G	124265822	C	G	124265822	3	3	118	1	0	0	0	0	1	0	0	0	4598	827	29	1	656	1	DNAH10	12	124265822	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1447164	124265822	9586073	122	35673										
DNAH10	196385	broad.mit.edu	37	chr12	124359912	124359912	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tttattgctgcaatgggaaaGgctggaggaggccgcaatga	15	6	0	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr12:124359912G>A	uc001uft.3	+	46	7744	c.7719G>A	c.(7717-7719)AAG>AAA	p.K2573K		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2573	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAATGGGAAAGGCTGGAGGAG	0.438													0	0	0	0.001984	0	7	32										A	124359912	G	A	124359912	2	1	118	1	0	0	0	0	0	0	0	1	4598	991	35	2		2	DNAH10	12	124359912	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	94090	124359912	9491983	123	35674										
ARHGEF7	8874	broad.mit.edu	37	chr13	111929950	111929950	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttaggaaaagaatgaaagatAtcttctactcttcccaaatg	6	7	3	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr13:111929950A>C	uc001vrs.2	+	14	1749	c.1499A>C	c.(1498-1500)TAT>TCT	p.Y500S	ARHGEF7_uc001vrr.2_Missense_Mutation_p.Y479S|ARHGEF7_uc001vrt.2_Missense_Mutation_p.Y450S|ARHGEF7_uc010tjn.1_RNA|ARHGEF7_uc001vru.1_Missense_Mutation_p.Y322S|ARHGEF7_uc001vrv.3_Missense_Mutation_p.Y322S|ARHGEF7_uc001vrw.3_Missense_Mutation_p.Y322S|ARHGEF7_uc001vrx.3_Missense_Mutation_p.Y322S|ARHGEF7_uc010tjo.1_Missense_Mutation_p.Y397S|ARHGEF7_uc010tjp.1_Missense_Mutation_p.Y244S	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	500	PH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			AATGAAAGATATCTTCTACTC	0.279													0	0	0	0.004656	0	25	44										C	111929950	A	C	111929950	3	2	118	1	0	0	0	0	1	0	0	0	911	449	16	5	1553	5	ARHGEF7	13	111929950	Missense_Mutation	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08		111929950	3239928	124	35675										
OR4M1	441670	broad.mit.edu	37	chr14	20249177	20249177	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aagaaacattcaggctcaggTgagaataccaacagggccat	10	9	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr14:20249177T>A	uc010tku.1	+	1	696	c.696T>A	c.(694-696)GGT>GGA	p.G232G		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGGCTCAGGTGAGAATACCA	0.463													0	0	0	0.01441	0	61	167										A	20249177	T	A	20249177	2	1	118	1	0	0	0	0	0	0	0	1	11075	1683	59	5		5	OR4M1	14	20249177	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08		20249177	87100363	125	35676										
NUBPL	80224	broad.mit.edu	37	chr14	32315779	32315779	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caaggaaactagcacagaccCttggtcttgaagttctaggt	10	9	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr14:32315779C>T	uc001wrk.3	+	9	851	c.796C>T	c.(796-798)CTT>TTT	p.L266F	NUBPL_uc010amj.2_RNA|NUBPL_uc010tpl.1_Missense_Mutation_p.L170F	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	266					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		AGCACAGACCCTTGGTCTTGA	0.428													0	0	0	0.001168	0	6	12										T	32315779	C	T	32315779	3	4	118	1	0	0	0	0	1	0	0	0	10717	681	24	2	830	2	NUBPL	14	32315779	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	12066602	32315779	75033761	126	35677										
ZFP36L1	677	broad.mit.edu	37	chr14	69256673	69256674	+	Frame_Shift_Ins	INS	-	-	A													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	caaagctaaagctatgctggINSaggcggggacggtcagcgga							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr14:69256673_69256674insA	uc001xkh.1	-	2	723_724	c.593_594insT	c.(592-594)CTCfs	p.L198fs	ZFP36L1_uc001xki.1_Frame_Shift_Ins_p.L198fs	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	198					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGCTATGCTGGAGGCGGGGACG	0.584											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						29	29	---	---								A	69256674	-	A	69256673	7	5	118	1	0	1	1	0	0	0	0	0	17643	1161	41	0	426	0	ZFP36L1	14	69256673	Frame_Shift_Ins	INS	-	TCGA-GV-A3QF-01A-31D-A22Z-08	36940894	69256673	38092867	127	35678										
PDIA3	2923	broad.mit.edu	37	chr15	44055308	44055308	+	Frame_Shift_Del	DEL	C	C	-													0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttcattcagtgaggctcactCcgagttcctaaaagcagcca							TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr15:44055308delC	uc001zsu.2	+	5	654	c.506delC	c.(505-507)TCCfs	p.S169fs	PDIA3_uc010bdp.2_Frame_Shift_Del_p.S149fs|PDIA3_uc010ued.1_5'UTR	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	169					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		GAGGCTCACTCCGAGTTCCTA	0.398																		30	91	---	---								-	44055308	C	-	44055308	7	5	118	1	0	1	0	1	0	0	0	0	11669	855	30	0	524	0	PDIA3	15	44055308	Frame_Shift_Del	DEL	C	TCGA-GV-A3QF-01A-31D-A22Z-08		44055308	58476084	128	35679										
STOML1	9399	broad.mit.edu	37	chr15	74281034	74281034	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tggcgttctgggctgtcatgCgtgtggctgtgttcaggtct	16	8	4	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr15:74281034C>T	uc002awe.2	-	4	571	c.500G>A	c.(499-501)CGC>CAC	p.R167H	STOML1_uc002awf.2_Missense_Mutation_p.R167H|STOML1_uc010bje.2_Missense_Mutation_p.R167H|STOML1_uc010uld.1_Missense_Mutation_p.R125H|STOML1_uc002awh.2_Missense_Mutation_p.R117H|STOML1_uc002awg.2_Missense_Mutation_p.R117H|STOML1_uc002awi.2_Missense_Mutation_p.R80H	NM_004809	NP_004800	Q9UBI4	STML1_HUMAN	stomatin (EPB72)-like 1	167	Cytoplasmic (Potential).					integral to membrane	sterol binding			skin(1)	1						GGCTGTCATGCGTGTGGCTGT	0.602													0	0	0	0.007835	0	43	34										T	74281034	C	T	74281034	3	4	118	1	0	0	0	0	1	0	0	0	15312	768	27	2	712	2	STOML1	15	74281034	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	30225726	74281034	28250358	129	35680										
SRRM2	23524	broad.mit.edu	37	chr16	2813316	2813316	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atatcaccaagacaaagaagCcattctggctcctcttctcc	5	14	4	2	rs137907192	byFrequency	TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:2813316C>T	uc002crk.2	+	11	3336	c.2787C>T	c.(2785-2787)AGC>AGT	p.S929S	SRRM2_uc002crj.1_Silent_p.S833S|SRRM2_uc002crl.1_Silent_p.S929S|SRRM2_uc010bsu.1_Silent_p.S833S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	929	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GACAAAGAAGCCATTCTGGCT	0.493													0	0	0	0.001984	0	6	93										T	2813316	C	T	2813316	2	4	118	1	0	0	0	0	0	0	0	1	15168	738	26	2		2	SRRM2	16	2813316	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		2813316	87541437	130	35681										
A2BP1	54715	broad.mit.edu	37	chr16	7645613	7645613	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agggcgagggagaaattacaCggcaccgtggtagagggccg	18	8	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:7645613C>T	uc002cys.2	+	8	1519	c.531C>T	c.(529-531)CAC>CAT	p.H177H	A2BP1_uc010buf.1_Silent_p.H177H|A2BP1_uc002cyr.1_Silent_p.H176H|A2BP1_uc002cyt.2_Silent_p.H177H|A2BP1_uc010uxz.1_Silent_p.H220H|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Silent_p.H177H|A2BP1_uc010uyb.1_Silent_p.H177H|A2BP1_uc002cyw.2_Silent_p.H197H|A2BP1_uc002cyy.2_Silent_p.H197H|A2BP1_uc002cyx.2_Silent_p.H197H|A2BP1_uc010uyc.1_Silent_p.H197H	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	177	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AGAAATTACACGGCACCGTGG	0.448													0	0	0	0.00333	0	23	92										T	7645613	C	T	7645613	2	4	118	1	0	0	0	0	0	0	0	1	3	535	19	2		2	A2BP1	16	7645613	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	4832297	7645613	82709140	131	35682										
DNAH3	55567	broad.mit.edu	37	chr16	21061283	21061283	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tggtttctgtcttgccagtcCcagctggaccctctggagca	11	13	3	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:21061283C>T	uc010vbe.1	-	30	4295	c.4295G>A	c.(4294-4296)GGG>GAG	p.G1432E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1432	ATP (Potential).|AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTTGCCAGTCCCAGCTGGACC	0.522													0	0	0	0.001855	0	13	67										T	21061283	C	T	21061283	3	4	118	1	0	0	0	0	1	0	0	0	4603	623	22	2	8186	2	DNAH3	16	21061283	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	13415670	21061283	69293470	132	35683										
SHCBP1	79801	broad.mit.edu	37	chr16	46638001	46638001	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tgagtgatcttctgaccgctGgaacggacaccctttgcttg	11	11	2	3			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:46638001G>T	uc002eec.3	-	7	1018	c.978C>A	c.(976-978)TCC>TCA	p.S326S		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	326										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				TCTGACCGCTGGAACGGACAC	0.493													1	0	4.4004e-07	0.00333	4.72917e-07	25	92										T	46638001	G	T	46638001	2	4	118	1	0	0	0	0	0	0	0	1	14274	1335	47	4		4	SHCBP1	16	46638001	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	25576718	46638001	43716752	133	35684										
CNOT1	23019	broad.mit.edu	37	chr16	58620581	58620581	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atcttggaagccaccttcttGatttccactgacgtctgcgt	8	12	3	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:58620581G>A	uc002env.2	-	7	798	c.505C>T	c.(505-507)CAA>TAA	p.Q169*	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Nonsense_Mutation_p.Q169*|CNOT1_uc002enx.2_Nonsense_Mutation_p.Q169*|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	169					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CCACCTTCTTGATTTCCACTG	0.473													0	0	0	0.01441	0	119	165										A	58620581	G	A	58620581	4	1	118	1	0	0	0	0	0	1	0	0	3617	1299	45	1	7019	1	CNOT1	16	58620581	Nonsense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	11982580	58620581	31734172	134	35685										
WWOX	51741	broad.mit.edu	37	chr16	78198152	78198152	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ctgcaggaacatggcaagggCgagtgaagcagtgtcacgca	15	9	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr16:78198152C>T	uc002ffk.2	+	5	607	c.482C>T	c.(481-483)GCG>GTG	p.A161V	WWOX_uc010vnk.1_Missense_Mutation_p.A48V|WWOX_uc002ffl.2_Missense_Mutation_p.A161V|WWOX_uc010che.2_Intron|WWOX_uc002ffj.1_Missense_Mutation_p.A161V	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	161	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)		ATGGCAAGGGCGAGTGAAGCA	0.448													0	0	0	0.000602	0	4	28										T	78198152	C	T	78198152	3	4	118	1	0	0	0	0	1	0	0	0	17411	768	27	2	504	2	WWOX	16	78198152	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	19577571	78198152	12156601	135	35686										
SMYD4	114826	broad.mit.edu	37	chr17	1690224	1690224	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aagaaatactgagacctcagCttctgctgcctttcggcaac	8	12	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr17:1690224C>A	uc002ftm.3	-	7	1932	c.1764G>T	c.(1762-1764)AAG>AAT	p.K588N	SMYD4_uc002ftn.1_Missense_Mutation_p.K443N	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	588							zinc ion binding			skin(3)|kidney(2)	5						GAGACCTCAGCTTCTGCTGCC	0.542													1	0	1.49906e-05	0.00245	1.55736e-05	13	18										A	1690224	C	A	1690224	3	1	118	1	0	0	0	0	1	0	0	0	14824	796	28	4	670	4	SMYD4	17	1690224	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		1690224	79504986	136	35687										
CCDC42	146849	broad.mit.edu	37	chr17	8638796	8638796	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gcaggatctcatcatcctttTcctccatgtagcgcgccagc	8	15	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr17:8638796T>C	uc002gln.2	-	5	853	c.626A>G	c.(625-627)GAA>GGA	p.E209G	CCDC42_uc002glo.2_Intron	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	209	Potential.			Missing (in Ref. 2; AAH29224).						ovary(1)	1						ATCATCCTTTTCCTCCATGTA	0.562													0	0	0	0.00308	0	8	35										C	8638796	T	C	8638796	3	2	118	1	0	0	0	0	1	0	0	0	2814	1783	62	5	336	5	CCDC42	17	8638796	Missense_Mutation	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	6948572	8638796	72556414	137	35688										
BRIP1	83990	broad.mit.edu	37	chr17	59821938	59821938	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gtagagagccaacgttctttTaatttttctaataactaaag	6	6	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr17:59821938T>C	uc002izk.1	-	15	2253	c.2112A>G	c.(2110-2112)TTA>TTG	p.L704L	BRIP1_uc002izl.1_Silent_p.L85L	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	704					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						AACGTTCTTTTAATTTTTCTA	0.308			F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	66	108										C	59821938	T	C	59821938	2	2	118	1	0	0	0	0	0	0	0	1	1514	1751	61	5		5	BRIP1	17	59821938	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	51183142	59821938	21373272	138	35689										
PTPN2	5771	broad.mit.edu	37	chr18	12794331	12794331	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccaacaaaagcgccaaccaaAatgactgacataaaccccat	4	14	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr18:12794331A>T	uc002krp.2	-	9	1388	c.1194T>A	c.(1192-1194)ATT>ATA	p.I398I	PTPN2_uc002krl.2_Intron|PTPN2_uc002krn.2_Intron|PTPN2_uc002kro.2_Intron|PTPN2_uc002krm.2_Intron	NM_002828	NP_002819	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type	398					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			skin(2)	2		Lung NSC(161;8.94e-06)				CGCCAACCAAAATGACTGACA	0.398													0	0	0	0.012319	0	20	79										T	12794331	A	T	12794331	2	4	118	1	0	0	0	0	0	0	0	1	12785	10	1	5		5	PTPN2	18	12794331	Silent	SNP	A	TCGA-GV-A3QF-01A-31D-A22Z-08		12794331	65282917	139	35690										
WDR7	23335	broad.mit.edu	37	chr18	54694285	54694285	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atgctgaactcggcacctcaGctgcgctgcattaaaaccta	8	13	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr18:54694285G>A	uc002lgk.1	+	28	4531	c.4320G>A	c.(4318-4320)CAG>CAA	p.Q1440Q	WDR7_uc002lgl.1_Silent_p.Q1407Q	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1440										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		CGGCACCTCAGCTGCGCTGCA	0.607													0	0	0	0.007835	0	41	32										A	54694285	G	A	54694285	2	1	118	1	0	0	0	0	0	0	0	1	17317	962	34	2		2	WDR7	18	54694285	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	41899954	54694285	23382963	140	35691										
GALR1	2587	broad.mit.edu	37	chr18	74980672	74980672	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ttcctcttcagaatcaccgcCcactgcctggcgtacagcaa	7	16	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr18:74980672C>T	uc002lms.3	+	3	1361	c.864C>T	c.(862-864)GCC>GCT	p.A288A		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	288	Helical; Name=7; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		GAATCACCGCCCACTGCCTGG	0.493													0	0	0	0.01441	0	49	28										T	74980672	C	T	74980672	2	4	118	1	0	0	0	0	0	0	0	1	6227	610	22	2		2	GALR1	18	74980672	Silent	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	20286387	74980672	3096576	141	35692										
AP3D1	8943	broad.mit.edu	37	chr19	2121015	2121015	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cttcacgcggatggccacgtCcagcatttgggcggcgatga	14	12	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:2121015C>A	uc002luz.2	-	14	1550	c.1327G>T	c.(1327-1329)GAC>TAC	p.D443Y	AP3D1_uc002luy.2_Missense_Mutation_p.D352Y|AP3D1_uc002lva.2_Missense_Mutation_p.D443Y	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	443	HEAT 9.				eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGGCCACGTCCAGCATTTGG	0.652													1	0	4.3838e-07	0.001855	4.72917e-07	12	50										A	2121015	C	A	2121015	3	1	118	1	0	0	0	0	1	0	0	0	746	855	30	3	2360	3	AP3D1	19	2121015	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		2121015	57007968	142	35693										
FBN3	84467	broad.mit.edu	37	chr19	8161817	8161817	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cctcgggtgcacttgcagcgGtagctaccggggatgttgat	15	10	0	1	rs138081025		TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:8161817G>A	uc002mjf.2	-	42	5382	c.5361C>T	c.(5359-5361)TAC>TAT	p.Y1787Y		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1787	EGF-like 27; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						ACTTGCAGCGGTAGCTACCGG	0.607													0	0	0	0.00278	0	25	55										A	8161817	G	A	8161817	2	1	118	1	0	0	0	0	0	0	0	1	5704	1256	44	2		2	FBN3	19	8161817	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	6040802	8161817	50967166	143	35694										
GATAD2A	54815	broad.mit.edu	37	chr19	19612809	19612809	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccggcgtaagttggcgttccGctcaggagaggcccgcgact	15	13	1	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:19612809G>A	uc010xqt.1	+	10	1844	c.1532G>A	c.(1531-1533)CGC>CAC	p.R511H	GATAD2A_uc010xqu.1_Missense_Mutation_p.R140H|GATAD2A_uc010xqv.1_Missense_Mutation_p.R531H|GATAD2A_uc010xqw.1_Intron	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	511					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTGGCGTTCCGCTCAGGAGAG	0.667													0	0	0	0.012319	0	18	69										A	19612809	G	A	19612809	3	1	118	1	0	0	0	0	1	0	0	0	6260	1087	38	2	1566	2	GATAD2A	19	19612809	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	11450992	19612809	39516174	144	35695										
ZNF536	9745	broad.mit.edu	37	chr19	30934886	30934886	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccactctgcggcaagcgcttCcgcttcaacagcatcctctc	7	18	3	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:30934886C>A	uc002nsu.1	+	2	555	c.417C>A	c.(415-417)TTC>TTA	p.F139L	ZNF536_uc010edd.1_Missense_Mutation_p.F139L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	139	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.F139F(1)		ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCAAGCGCTTCCGCTTCAACA	0.637													1	0	4.87955e-14	0.005443	5.59802e-14	25	67										A	30934886	C	A	30934886	3	1	118	1	0	0	0	0	1	0	0	0	17971	854	30	3	419	3	ZNF536	19	30934886	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	11322077	30934886	28194097	145	35696										
TSHZ3	57616	broad.mit.edu	37	chr19	31769796	31769796	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ggttccttcagaggcactttTtggtagtgttttgttttgat	11	5	1	2	rs61747216	byFrequency	TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:31769796T>C	uc002nsy.3	-	2	968	c.903A>G	c.(901-903)CAA>CAG	p.Q301Q		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	301					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GAGGCACTTTTTGGTAGTGTT	0.537													0	0	0	0.009718	0	44	96										C	31769796	T	C	31769796	2	2	118	1	0	0	0	0	0	0	0	1	16622	1838	64	5		5	TSHZ3	19	31769796	Silent	SNP	T	TCGA-GV-A3QF-01A-31D-A22Z-08	834910	31769796	27359187	146	35697										
TTC9B	148014	broad.mit.edu	37	chr19	40722099	40722099	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tacatcccgagtctgggaccCagccccactgtcttcccgct	8	18	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:40722099C>T	uc002onc.2	-	3	709	c.691G>A	c.(691-693)GGG>AGG	p.G231R		NM_152479	NP_689692	Q8N6N2	TTC9B_HUMAN	tetratricopeptide repeat domain 9B	231							binding				0						GTCTGGGACCCAGCCCCACTG	0.597													0	0	0	0.003271	0	32	63										T	40722099	C	T	40722099	3	4	118	1	0	0	0	0	1	0	0	0	16713	594	21	2	32	2	TTC9B	19	40722099	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	8952303	40722099	18406884	147	35698										
ZNF574	64763	broad.mit.edu	37	chr19	42583136	42583136	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	agctccagcaccatccactaCgagtgtgtggattgcaaggc	11	12	0	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:42583136C>G	uc002osm.3	+	2	547	c.378C>G	c.(376-378)TAC>TAG	p.Y126*	ZNF574_uc002osk.3_Nonsense_Mutation_p.Y216*	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	126	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CCATCCACTACGAGTGTGTGG	0.632													0	0	0	0.00278	0	25	80										G	42583136	C	G	42583136	4	3	118	1	0	0	0	0	0	1	0	0	18003	547	19	4	380	4	ZNF574	19	42583136	Nonsense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1861037	42583136	16545847	148	35699										
IZUMO1	284359	broad.mit.edu	37	chr19	49248950	49248950	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccttcacggcattctctaccCtttccatcatggctttgtga	6	14	3	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:49248950C>A	uc002pkj.2	-	2	715	c.167G>T	c.(166-168)AGG>ATG	p.R56M	IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	56	Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		ATTCTCTACCCTTTCCATCAT	0.552													1	0	6.1244e-12	0.007835	6.94099e-12	41	106										A	49248950	C	A	49248950	3	1	118	1	0	0	0	0	1	0	0	0	7933	681	24	4	921	4	IZUMO1	19	49248950	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	6665814	49248950	9880033	149	35700										
SHANK1	50944	broad.mit.edu	37	chr19	51171701	51171701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gcctcggtgctgctgccctgGctgctgcggccgctgctact	14	16	0	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr19:51171701G>A	uc002psx.1	-	22	3535	c.3516C>T	c.(3514-3516)AGC>AGT	p.S1172S	SHANK1_uc002psw.1_Silent_p.S556S	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1172					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGCTGCCCTGGCTGCTGCGGC	0.522													0	0	0	0.004007	0	11	15										A	51171701	G	A	51171701	2	1	118	1	0	0	0	0	0	0	0	1	14264	1194	42	2		2	SHANK1	19	51171701	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	1922751	51171701	7957282	150	35701										
ZNF341	84905	broad.mit.edu	37	chr20	32349815	32349815	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	cgaaactctgtgaccgtacaGgtcatggccctgaaccccag	10	14	2	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:32349815G>A	uc002wzy.2	+	8	1196	c.1176G>A	c.(1174-1176)CAG>CAA	p.Q392Q	ZNF341_uc002wzx.2_Silent_p.Q385Q|ZNF341_uc010geq.2_Silent_p.Q302Q|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGACCGTACAGGTCATGGCCC	0.567													0	0	0	0.007835	0	37	77										A	32349815	G	A	32349815	2	1	118	1	0	0	0	0	0	0	0	1	17854	991	35	2		2	ZNF341	20	32349815	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08		32349815	30675705	151	35702										
CPNE1	8904	broad.mit.edu	37	chr20	34219095	34219095	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aaaggagtactctgtttctaCctgcaaatgaaaccagggtc	9	9	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:34219095C>T	uc002xdf.2	-	12	1165	c.802G>A	c.(802-804)GTA>ATA	p.V268I	CPNE1_uc002xdc.2_5'UTR|CPNE1_uc010zvj.1_Missense_Mutation_p.V273I|CPNE1_uc002xde.2_Missense_Mutation_p.V244I|CPNE1_uc002xdg.2_Missense_Mutation_p.V268I|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Missense_Mutation_p.V268I|CPNE1_uc002xdi.2_Missense_Mutation_p.V268I|CPNE1_uc002xdj.2_Missense_Mutation_p.V268I|CPNE1_uc002xdk.2_Missense_Mutation_p.V268I|CPNE1_uc002xdl.2_Missense_Mutation_p.V268I|CPNE1_uc002xdm.2_Missense_Mutation_p.V268I|CPNE1_uc010gfk.1_Missense_Mutation_p.V268I	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	268					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TCTGTTTCTACCTGCAAATGA	0.493													0	0	0	0.01441	0	64	157										T	34219095	C	T	34219095	3	4	118	1	0	0	0	0	1	0	0	0	3811	521	18	2	839	2	CPNE1	20	34219095	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	1869280	34219095	28806425	152	35703										
KIAA0406	9675	broad.mit.edu	37	chr20	36611923	36611923	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gttctgctgcccgctggcccCgtgcagctgcacagggtgga	15	14	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:36611923C>T	uc002xhl.2	-	9	3414	c.3205G>A	c.(3205-3207)GGG>AGG	p.G1069R	KIAA0406_uc002xhm.2_Missense_Mutation_p.G1069R	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	1069							binding				0		Myeloproliferative disorder(115;0.00874)				CCGCTGGCCCCGTGCAGCTGC	0.652													0	0	0	0.001855	0	12	32										T	36611923	C	T	36611923	3	4	118	1	0	0	0	0	1	0	0	0	8173	652	23	2	68	2	KIAA0406	20	36611923	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	2392828	36611923	26413597	153	35704										
CDH4	1002	broad.mit.edu	37	chr20	60508129	60508129	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	tcattgaccccgaggacgacGtccgcgacaacatcctcaag	9	15	2	1	rs142330895		TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr20:60508129G>A	uc002ybn.1	+	14	2340	c.2326G>A	c.(2326-2328)GTC>ATC	p.V776I	CDH4_uc002ybp.1_Missense_Mutation_p.V702I	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	776	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CGAGGACGACGTCCGCGACAA	0.657													0	0	0	0.003954	0	21	56										A	60508129	G	A	60508129	3	1	118	1	0	0	0	0	1	0	0	0	3112	1145	40	2	2380	2	CDH4	20	60508129	Missense_Mutation	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	23896206	60508129	2517391	154	35705										
PWP2	5822	broad.mit.edu	37	chr21	45542227	45542227	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	aagattacagccaagcacgcGgccaaggggaagtgagtgtc	14	9	0	2			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr21:45542227G>A	uc002zeb.2	+	14	1896	c.1806G>A	c.(1804-1806)GCG>GCA	p.A602A		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	602						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CCAAGCACGCGGCCAAGGGGA	0.582													0	0	0	0.006214	0	10	43										A	45542227	G	A	45542227	2	1	118	1	0	0	0	0	0	0	0	1	12844	1103	39	2		2	PWP2	21	45542227	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08		45542227	2587668	155	35706										
ITGB2	3689	broad.mit.edu	37	chr21	46306766	46306766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	gaatgccgatcagcacgatgCctgccacggtgcccccgacg	12	16	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chr21:46306766C>T	uc002zgd.2	-	14	2176	c.2132G>A	c.(2131-2133)GGC>GAC	p.G711D	ITGB2_uc002zge.2_Missense_Mutation_p.G711D|ITGB2_uc002zgf.3_Missense_Mutation_p.G711D|ITGB2_uc011afl.1_Missense_Mutation_p.G633D|ITGB2_uc010gpw.2_Missense_Mutation_p.G654D|ITGB2_uc002zgg.2_Missense_Mutation_p.G711D	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	711	Helical; (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	CAGCACGATGCCTGCCACGGT	0.612													0	0	0	0.004482	0	7	57										T	46306766	C	T	46306766	3	4	118	1	0	0	0	0	1	0	0	0	7894	739	26	2	185	2	ITGB2	21	46306766	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	764539	46306766	1823129	156	35707										
KDM6A	7403	broad.mit.edu	37	chrX	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ccagagtgcctagcgtctctCagcctggagtccgtcctgcc	11	16	2	1			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.005443	0	27	12										T	44922802	C	T	44922802	4	4	118	1	0	0	0	0	0	1	0	0	8137	827	29	1	1725	1	KDM6A	23	44922802	Nonsense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08		44922802	110347758	157	35708										
GPR173	54328	broad.mit.edu	37	chrX	53106253	53106253	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	atctgcatggcctggaccctGtctgtggccatggccttccc	11	15	2	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chrX:53106253G>A	uc004dru.2	+	2	708	c.450G>A	c.(448-450)CTG>CTA	p.L150L		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	150	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCTGGACCCTGTCTGTGGCCA	0.587													0	0	0	0.010729	0	12	19										A	53106253	G	A	53106253	2	1	118	1	0	0	0	0	0	0	0	1	6671	1364	48	2		2	GPR173	23	53106253	Silent	SNP	G	TCGA-GV-A3QF-01A-31D-A22Z-08	8183451	53106253	102164307	158	35709										
MAGEA10	4109	broad.mit.edu	37	chrX	151303231	151303231	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.146496815286624	23	0.000818463798687554	2.03670703575548	3.76348039215686	1.50539215686275	0.582571722137745	0.7111952018206	12	ataccgtgcaggatcactgcCaggcacctgccggtactcca	10	15	1	0			TCGA-GV-A3QF-01A-31D-A22Z-08	TCGA-GV-A3QF-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1948230a-2e9d-4557-b37e-dfee2537901b	aebf15c2-06c0-45fd-873c-1f784bb15385	g.chrX:151303231C>T	uc004ffk.2	-	5	1270	c.862G>A	c.(862-864)GGC>AGC	p.G288S	MAGEA10_uc004ffl.2_Missense_Mutation_p.G288S	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	288	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GGATCACTGCCAGGCACCTGC	0.522													0	0	0	0.01441	0	69	36										T	151303231	C	T	151303231	3	4	118	1	0	0	0	0	1	0	0	0	9164	594	21	2	251	2	MAGEA10	23	151303231	Missense_Mutation	SNP	C	TCGA-GV-A3QF-01A-31D-A22Z-08	98196978	151303231	3967329	159	35710										
ENO1	2023	broad.mit.edu	37	chr1	8934961	8934961	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cctggcatggatcttgagaaTagacatggtgaacttctgta	11	7	2	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:8934961T>C	uc001apj.1	-	2	158	c.7A>G	c.(7-9)ATT>GTT	p.I3V	ENO1_uc001apk.1_5'UTR|ENO1_uc001apl.1_Missense_Mutation_p.I3V|ENO1_uc009vmi.1_Missense_Mutation_p.I3V|ENO1_uc009vmj.1_Missense_Mutation_p.I3V|ENO1_uc009vmk.1_5'UTR|ENO1_uc009vml.1_Missense_Mutation_p.I3V|ENO1_uc009vmm.1_RNA	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	3					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		ATCTTGAGAATAGACATGGTG	0.448													0	0	0	0.007835	0	38	38										C	8934961	T	C	8934961	3	2	119	1	0	0	0	0	1	0	0	0	5121	1406	49	5	1341	5	ENO1	1	8934961	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08		8934961	240315660	1	35711										
FMO5	2330	broad.mit.edu	37	chr1	146684955	146684955	+	Frame_Shift_Del	DEL	T	T	-													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	catcaaagacattcatctccTttttcccttcagattcagtg							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:146684955delT	uc001epi.2	-	4	796	c.407delA	c.(406-408)AAGfs	p.K136fs	FMO5_uc001eph.3_Frame_Shift_Del_p.K136fs|FMO5_uc001epj.2_Frame_Shift_Del_p.K136fs|FMO5_uc001epk.3_Frame_Shift_Del_p.K136fs	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	136						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					ATTCATCTCCTTTTTCCCTTC	0.473																		8	600	---	---								-	146684955	T	-	146684955	7	5	119	1	0	1	0	1	0	0	0	0	5958	1609	56	0	1361	0	FMO5	1	146684955	Frame_Shift_Del	DEL	T	TCGA-GV-A3QG-01A-11D-A21Z-08	137749994	146684955	102565666	2	35712										
BAT2L2	23215	broad.mit.edu	37	chr1	171510162	171510162	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	agattggtttccagatcaagGatacagaggtcgaggccgag	14	7	1	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:171510162G>T	uc010pmg.1	+	16	3817	c.3551G>T	c.(3550-3552)GGA>GTA	p.G1184V	BAT2L2_uc010pmh.1_Missense_Mutation_p.G161V	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	1184							protein C-terminus binding				0						CCAGATCAAGGATACAGAGGT	0.493													1	0	4.36969e-10	0.001855	5.34073e-10	13	64										T	171510162	G	T	171510162	3	4	119	1	0	0	0	0	1	0	0	0	1321	1174	41	3	3609	3	BAT2L2	1	171510162	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	24825207	171510162	77740459	3	35713										
HMCN1	83872	broad.mit.edu	37	chr1	185972852	185972852	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acactgtctttgttcaagttCcacccaccataataggtacc	5	13	2	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:185972852C>G	uc001grq.1	+	29	4580	c.4351C>G	c.(4351-4353)CCA>GCA	p.P1451A		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1451					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGTTCAAGTTCCACCCACCAT	0.433													0	0	0	0.00308	0	7	119										G	185972852	C	G	185972852	3	3	119	1	0	0	0	0	1	0	0	0	7220	855	30	1	4465	1	HMCN1	1	185972852	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	14462690	185972852	63277769	4	35714										
CENPF	1063	broad.mit.edu	37	chr1	214814730	214814730	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gcatttcagagttatctgatCagtacaagcaagaaaaactt	7	7	3	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:214814730C>T	uc001hkm.2	+	12	3223	c.3049C>T	c.(3049-3051)CAG>TAG	p.Q1017*		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1017	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GTTATCTGATCAGTACAAGCA	0.333													0	0	0	0.006122	0	16	79										T	214814730	C	T	214814730	4	4	119	1	0	0	0	0	0	1	0	0	3231	827	29	1	3091	1	CENPF	1	214814730	Nonsense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	28841878	214814730	34435891	5	35715										
OR2B11	127623	broad.mit.edu	37	chr1	247614709	247614709	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ttcacagcggtgtcagcacaCgacagcttgatcacggccgg	12	13	3	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:247614709C>T	uc010pyx.1	-	1	576	c.576G>A	c.(574-576)TCG>TCA	p.S192S		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	192	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TGTCAGCACACGACAGCTTGA	0.562													0	0	0	0.001984	0	7	32										T	247614709	C	T	247614709	2	4	119	1	0	0	0	0	0	0	0	1	10988	523	19	2		2	OR2B11	1	247614709	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	32799979	247614709	1635912	6	35716										
OR11L1	391189	broad.mit.edu	37	chr1	248005058	248005058	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cgcaggccctggctcaccacGgtgatgatgacaacattccc	10	15	1	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr1:248005058G>A	uc001idn.1	-	1	141	c.141C>T	c.(139-141)ACC>ACT	p.T47T		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	47	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTCACCACGGTGATGATGA	0.522													0	0	0	0.013537	0	10	27										A	248005058	G	A	248005058	2	1	119	1	0	0	0	0	0	0	0	1	10930	1103	39	2		2	OR11L1	1	248005058	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	390349	248005058	1245563	7	35717										
MSGN1	343930	broad.mit.edu	37	chr2	17998336	17998336	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	actcacagacctccttaaccGcggcagagagcccagagccc	9	17	1	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:17998336G>A	uc010yjt.1	+	1	551	c.551G>A	c.(550-552)CGC>CAC	p.R184H		NM_001105569	NP_001099039	A6NI15	MSGN1_HUMAN	mesogenin 1	184					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTCCTTAACCGCGGCAGAGAG	0.577													0	0	0	0.006122	0	13	49										A	17998336	G	A	17998336	3	1	119	1	0	0	0	0	1	0	0	0	9869	1087	38	2	553	2	MSGN1	2	17998336	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		17998336	225201037	8	35718										
PLEKHH2	130271	broad.mit.edu	37	chr2	43939394	43939394	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aaaaacacacatactatctgActgcagattctcccaatata	3	11	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:43939394A>T	uc010yny.1	+	15	2415	c.2332A>T	c.(2332-2334)ACT>TCT	p.T778S	PLEKHH2_uc002rte.3_3'UTR|PLEKHH2_uc002rtf.3_Missense_Mutation_p.T777S	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	778	PH 1.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ATACTATCTGACTGCAGATTC	0.408													0	0	0	0.003755	0	27	132										T	43939394	A	T	43939394	3	4	119	1	0	0	0	0	1	0	0	0	12077	275	10	5	2386	5	PLEKHH2	2	43939394	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	25941058	43939394	199259979	9	35719										
USP34	9736	broad.mit.edu	37	chr2	61566811	61566811	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gaattgatgtttatgaactaCaggtcctgaagagaaaaaaa	9	4	0	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:61566811C>T	uc002sbe.2	-	17	2528	c.2506G>A	c.(2506-2508)GTA>ATA	p.V836I		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	836					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TTATGAACTACAGGTCCTGAA	0.328													0	0	0	0.001168	0	6	18										T	61566811	C	T	61566811	3	4	119	1	0	0	0	0	1	0	0	0	17062	478	17	2	8390	2	USP34	2	61566811	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	17627417	61566811	181632562	10	35720										
DYSF	8291	broad.mit.edu	37	chr2	71892312	71892312	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctctggaccgaaccagtggcGggaccagctccgcccctccc	11	19	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:71892312G>A	uc002sie.2	+	46	5454	c.5078G>A	c.(5077-5079)CGG>CAG	p.R1693Q	DYSF_uc010feg.2_Missense_Mutation_p.R1724Q|DYSF_uc010feh.2_Missense_Mutation_p.R1700Q|DYSF_uc002sig.3_Missense_Mutation_p.R1679Q|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1714Q|DYSF_uc010fef.2_Missense_Mutation_p.R1731Q|DYSF_uc010fei.2_Missense_Mutation_p.R1710Q|DYSF_uc010fek.2_Missense_Mutation_p.R1711Q|DYSF_uc010fej.2_Missense_Mutation_p.R1701Q|DYSF_uc010fel.2_Missense_Mutation_p.R1680Q|DYSF_uc010feo.2_Missense_Mutation_p.R1725Q|DYSF_uc010fem.2_Missense_Mutation_p.R1715Q|DYSF_uc010fen.2_Missense_Mutation_p.R1732Q|DYSF_uc002sif.2_Missense_Mutation_p.R1694Q|DYSF_uc010yqy.1_Missense_Mutation_p.R574Q|DYSF_uc010yqz.1_Missense_Mutation_p.R454Q	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1693	Cytoplasmic (Potential).		R -> Q (in MMD1).|R -> W (in MMD1).			cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						AACCAGTGGCGGGACCAGCTC	0.562													0	0	0	0.01441	0	42	167										A	71892312	G	A	71892312	3	1	119	1	0	0	0	0	1	0	0	0	4859	1116	39	2	5519	2	DYSF	2	71892312	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	10325501	71892312	171307061	11	35721										
AFF3	3899	broad.mit.edu	37	chr2	100209852	100209852	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctgatctcatcactgtccttTagaggggagagaagttcgtt	11	8	2	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:100209852T>C	uc002tag.2	-	14	2507	c.2271A>G	c.(2269-2271)CTA>CTG	p.L757L	AFF3_uc002taf.2_Silent_p.L782L|AFF3_uc010fiq.1_Silent_p.L757L|AFF3_uc010yvr.1_Silent_p.L910L|AFF3_uc002tah.1_Silent_p.L782L	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	757					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CACTGTCCTTTAGAGGGGAGA	0.577													0	0	0	0.004007	0	14	46										C	100209852	T	C	100209852	2	2	119	1	0	0	0	0	0	0	0	1	358	1741	61	5		5	AFF3	2	100209852	Silent	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	28317540	100209852	142989521	12	35722										
RGPD3	653489	broad.mit.edu	37	chr2	107040980	107040980	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctggtgttttaaattttgctGccaatcgctctagtttggca	9	8	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:107040980G>T	uc010ywi.1	-	20	3500	c.3443C>A	c.(3442-3444)GCA>GAA	p.A1148E		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1148	RanBD1 1.				intracellular transport		binding			ovary(1)	1						AAATTTTGCTGCCAATCGCTC	0.453													1	0	1.06801e-11	0.009535	1.34264e-11	29	170										T	107040980	G	T	107040980	3	4	119	1	0	0	0	0	1	0	0	0	13287	1319	46	4	1849	4	RGPD3	2	107040980	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	6831128	107040980	136158393	13	35723										
RANBP2	5903	broad.mit.edu	37	chr2	109379691	109379691	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gttttaactttctgtcttttAgggcccagtctatggcatga	9	8	3	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:109379691A>G	uc002tem.3	+	20	2824	c.2698_splice	c.e20-2	p.G900_splice		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TCTGTCTTTTAGGGCCCAGTC	0.398													0	0	0	0.006122	0	16	39										G	109379691	A	G	109379691	5	3	119	1	0	0	0	0	0	0	1	0	13028	434	15	5	2774	5	RANBP2	2	109379691	Splice_Site	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	2338711	109379691	133819682	14	35724										
NXPH2	11249	broad.mit.edu	37	chr2	139429145	139429145	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	actgatgatccttgagtgcaCcacgttgccgaccaacgtcc	9	14	0	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:139429145C>A	uc002tvi.2	-	2	142	c.142G>T	c.(142-144)GTG>TTG	p.V48L		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	48	II.				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		CTTGAGTGCACCACGTTGCCG	0.542													1	0	5.43694e-19	0.005524	7.1057e-19	33	132										A	139429145	C	A	139429145	3	1	119	1	0	0	0	0	1	0	0	0	10791	507	18	4	656	4	NXPH2	2	139429145	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	30049454	139429145	103770228	15	35725										
LRP2	4036	broad.mit.edu	37	chr2	170097513	170097513	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cttactgcaaagtggggactCatctgtcccattggggcagt	12	10	2	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:170097513C>G	uc002ues.2	-	25	4243	c.4030G>C	c.(4030-4032)GAG>CAG	p.E1344Q	LRP2_uc010zdf.1_Missense_Mutation_p.E1207Q	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1344	LDL-receptor class A 15.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGTGGGGACTCATCTGTCCCA	0.483													0	0	0	0.008361	0	28	78										G	170097513	C	G	170097513	3	3	119	1	0	0	0	0	1	0	0	0	8956	835	29	1	10157	1	LRP2	2	170097513	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	30668368	170097513	73101860	16	35726										
MAP1D	254042	broad.mit.edu	37	chr2	172928446	172928446	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctttttcctcaagcacataaAgaagccagactatgtgacga	7	10	1	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:172928446A>G	uc002uhk.2	+	3	279	c.206A>G	c.(205-207)AAG>AGG	p.K69R	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	69					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AAGCACATAAAGAAGCCAGAC	0.458													0	0	0	0.001168	0	4	19										G	172928446	A	G	172928446	3	3	119	1	0	0	0	0	1	0	0	0	9229	72	3	5	216	5	MAP1D	2	172928446	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	2830933	172928446	70270927	17	35727										
TTN	7273	broad.mit.edu	37	chr2	179629296	179629296	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgttgtggcaacaccatagtCattcttggcttcacaggtat	9	9	3	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:179629296C>T	uc010zfg.1	-	42	10170	c.9946G>A	c.(9946-9948)GAC>AAC	p.D3316N	TTN_uc010zfh.1_Missense_Mutation_p.D3270N|TTN_uc010zfi.1_Missense_Mutation_p.D3270N|TTN_uc010zfj.1_Missense_Mutation_p.D3270N|TTN_uc002umz.1_5'Flank|TTN_uc002unb.2_Missense_Mutation_p.D3316N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3316							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACCATAGTCATTCTTGGCT	0.453													0	0	0	0.004007	0	12	136										T	179629296	C	T	179629296	3	4	119	1	0	0	0	0	1	0	0	0	16732	826	29	1	101326	1	TTN	2	179629296	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	6700850	179629296	63570077	18	35728										
XRCC5	7520	broad.mit.edu	37	chr2	216992289	216992289	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	agagagttaaaaagacttggAcagttgtggatgcaaaaacc	11	5	0	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr2:216992289A>G	uc002vfy.2	+	8	969	c.829A>G	c.(829-831)ACA>GCA	p.T277A	XRCC5_uc002vfz.2_Missense_Mutation_p.T163A	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	277	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AAAGACTTGGACAGTTGTGGA	0.308								Direct_reversal_of_damage|NHEJ					0	0	0	0.001855	0	12	47										G	216992289	A	G	216992289	3	3	119	1	0	0	0	0	1	0	0	0	17453	275	10	5	859	5	XRCC5	2	216992289	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	37362993	216992289	26207084	19	35729										
LHFPL4	375323	broad.mit.edu	37	chr3	9547837	9547837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acacatgtcccggatggtctCggcatcccagccatcaggaa	10	14	2	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr3:9547837C>T	uc003bry.2	-	3	743	c.457G>A	c.(457-459)GAG>AAG	p.E153K		NM_198560	NP_940962	Q7Z7J7	LHPL4_HUMAN	lipoma HMGIC fusion partner-like 4	153						integral to membrane				ovary(2)|skin(1)	3	Medulloblastoma(99;0.227)					CGGATGGTCTCGGCATCCCAG	0.612													0	0	0	0.01441	0	71	101										T	9547837	C	T	9547837	3	4	119	1	0	0	0	0	1	0	0	0	8767	893	31	1	294	1	LHFPL4	3	9547837	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		9547837	188474593	20	35730										
SATB1	6304	broad.mit.edu	37	chr3	18427954	18427954	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cccatggccgaggcagcattCaagctcctttccctttcgtc	8	16	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr3:18427954C>T	uc003cbh.2	-	8	3091	c.1356G>A	c.(1354-1356)TTG>TTA	p.L452L	SATB1_uc003cbi.2_Silent_p.L452L|SATB1_uc003cbj.2_Silent_p.L452L	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	452					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						AGGCAGCATTCAAGCTCCTTT	0.547													0	0	0	0.013537	0	8	175										T	18427954	C	T	18427954	2	4	119	1	0	0	0	0	0	0	0	1	13853	825	29	1		1	SATB1	3	18427954	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	8880117	18427954	179594476	21	35731										
EFHB	151651	broad.mit.edu	37	chr3	19947209	19947209	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cacactacacctatggaaacTtgatgggttatactttcggt	8	9	0	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr3:19947209T>C	uc003cbl.3	-	6	1517	c.1321A>G	c.(1321-1323)AGT>GGT	p.S441G	EFHB_uc003cbm.2_Missense_Mutation_p.S311G	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	441					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CTATGGAAACTTGATGGGTTA	0.398													0	0	0	0.00632	0	27	43										C	19947209	T	C	19947209	3	2	119	1	0	0	0	0	1	0	0	0	4945	1609	56	5	1212	5	EFHB	3	19947209	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	1519255	19947209	178075221	22	35732										
MAP4	4134	broad.mit.edu	37	chr3	47958161	47958161	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aggagccaagtccatttttaTaggagatgccctctctgttt	9	9	1	1	rs142423472	byFrequency	TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr3:47958161T>C	uc003csb.2	-	7	1682	c.1156A>G	c.(1156-1158)ATA>GTA	p.I386V	MAP4_uc003csc.3_Missense_Mutation_p.I386V|MAP4_uc011bbf.1_Missense_Mutation_p.I363V|MAP4_uc003csf.3_Missense_Mutation_p.I403V	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	386	17 X 14 AA tandem repeats.|26 residues 2.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TCCATTTTTATAGGAGATGCC	0.453													0	0	0	0.00874	0	38	162										C	47958161	T	C	47958161	3	2	119	1	0	0	0	0	1	0	0	0	9258	1406	49	5	3713	5	MAP4	3	47958161	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	28010952	47958161	150064269	23	35733										
MORC1	27136	broad.mit.edu	37	chr3	108812380	108812380	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cttcaagttataaataaccaGcaaagtacctggtagaaaaa	6	7	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr3:108812380G>T	uc003dxl.2	-	8	679	c.592C>A	c.(592-594)CTG>ATG	p.L198M	MORC1_uc011bhn.1_Missense_Mutation_p.L198M	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	198					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TAAATAACCAGCAAAGTACCT	0.363													1	0	1.55795e-14	0.012319	2.01617e-14	17	41										T	108812380	G	T	108812380	3	4	119	1	0	0	0	0	1	0	0	0	9701	962	34	4	2446	4	MORC1	3	108812380	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	60854219	108812380	89210050	24	35734										
PLCH1	23007	broad.mit.edu	37	chr3	155206449	155206449	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aaaggccagctcatacctacCaggcactaagctgctgaagg	10	12	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr3:155206449C>A	uc011bok.1	-	19	2780	c.2503G>T	c.(2503-2505)GGC>TGC	p.G835C	PLCH1_uc011boj.1_Missense_Mutation_p.G835C|PLCH1_uc011bol.1_Missense_Mutation_p.G817C	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	835					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCATACCTACCAGGCACTAAG	0.418													1	0	2.35188e-11	0.006122	2.90139e-11	15	31										A	155206449	C	A	155206449	3	1	119	1	0	0	0	0	1	0	0	0	12037	608	21	4	2613	4	PLCH1	3	155206449	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	46394069	155206449	42815981	25	35735										
CYTL1	54360	broad.mit.edu	37	chr4	5016903	5016903	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gctgacgatctggcaggaccGtagtcactgggattgggtat	15	8	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr4:5016903G>A	uc003gig.2	-	4	411	c.386C>T	c.(385-387)ACG>ATG	p.T129M		NM_018659	NP_061129	Q9NRR1	CYTL1_HUMAN	cytokine-like 1 precursor	129					signal transduction	extracellular space|soluble fraction	receptor binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TGGCAGGACCGTAGTCACTGG	0.483													0	0	0	0.003954	0	18	49										A	5016903	G	A	5016903	3	1	119	1	0	0	0	0	1	0	0	0	4208	1145	40	2	28	2	CYTL1	4	5016903	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		5016903	186137373	26	35736										
LRRC66	339977	broad.mit.edu	37	chr4	52862091	52862091	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ggggagcgtcctcttttttgCcggcagcctgcacatcgcgg	14	13	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr4:52862091C>T	uc003gzi.2	-	4	1110	c.1097G>A	c.(1096-1098)GGC>GAC	p.G366D		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	366						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTCTTTTTTGCCGGCAGCCTG	0.592													0	0	0	0.001168	0	6	27										T	52862091	C	T	52862091	3	4	119	1	0	0	0	0	1	0	0	0	9018	739	26	2	1549	2	LRRC66	4	52862091	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	47845188	52862091	138292185	27	35737										
SHROOM3	57619	broad.mit.edu	37	chr4	77700119	77700119	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctaccagcacttcgtgaaaaTgaagtccacgctcctcattg	7	13	1	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr4:77700119T>C	uc011cbx.1	+	11	6733	c.5780T>C	c.(5779-5781)ATG>ACG	p.M1927T	SHROOM3_uc003hkg.2_Missense_Mutation_p.M1705T	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1927	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TTCGTGAAAATGAAGTCCACG	0.547													0	0	0	0.005443	0	24	82										C	77700119	T	C	77700119	3	2	119	1	0	0	0	0	1	0	0	0	14295	1464	51	5	5822	5	SHROOM3	4	77700119	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	24838028	77700119	113454157	28	35738										
ANK2	287	broad.mit.edu	37	chr4	114286340	114286340	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acactggatcatagtgaaggTcaaactgtgtgtgtgtatgt	12	5	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr4:114286340T>G	uc003ibe.3	+	41	11132	c.11032_splice	c.e41+2	p.G3678_splice	ANK2_uc003ibd.3_Splice_Site_p.G1584_splice|ANK2_uc003ibf.3_Splice_Site_p.G1593_splice|ANK2_uc011cgc.1_Splice_Site_p.G769_splice|ANK2_uc003ibg.3_Splice_Site_p.G577_splice|ANK2_uc003ibh.3_Splice_Site_p.G267_splice|ANK2_uc011cgd.1_Splice_Site_p.G980_splice	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATAGTGAAGGTCAAACtgtgt	0.294													0	0	0	0.001984	0	7	49										G	114286340	T	G	114286340	5	3	119	1	0	0	0	0	0	0	1	0	621	1681	58	5	11261	5	ANK2	4	114286340	Splice_Site	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	36586221	114286340	76867936	29	35739										
DCHS2	54798	broad.mit.edu	37	chr4	155191121	155191121	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgaatatttcatgctgtcctGaattgagtcaggagcaaaag	10	6	2	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr4:155191121G>A	uc003inw.2	-	19	5143	c.5143C>T	c.(5143-5145)CAG>TAG	p.Q1715*		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1715	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATGCTGTCCTGAATTGAGTCA	0.338													0	0	0	0.005443	0	21	69										A	155191121	G	A	155191121	4	1	119	1	0	0	0	0	0	1	0	0	4288	1299	45	1	3635	1	DCHS2	4	155191121	Nonsense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	40904781	155191121	35963155	30	35740										
ADAMTS6	11174	broad.mit.edu	37	chr5	64537939	64537939	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gttatacattacctccagtaTagggtttccagttataatac	6	8	0	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr5:64537939T>C	uc003jtp.2	-	15	2739	c.1925A>G	c.(1924-1926)TAT>TGT	p.Y642C	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.Y263C	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	642					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		ACCTCCAGTATAGGGTTTCCA	0.378													0	0	0	0.010729	0	9	40										C	64537939	T	C	64537939	3	2	119	1	0	0	0	0	1	0	0	0	270	1406	49	5	1472	5	ADAMTS6	5	64537939	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08		64537939	116377321	31	35741										
AQPEP	206338	broad.mit.edu	37	chr5	115323525	115323525	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tttagatacgcatctgggccCggaaagatgcaattgcaaat	10	8	1	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr5:115323525C>T	uc003kro.2	+	4	1158	c.994C>T	c.(994-996)CGG>TGG	p.R332W	AQPEP_uc003krp.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	332	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						CATCTGGGCCCGGAAAGATGC	0.418													0	0	0	0.00245	0	13	75										T	115323525	C	T	115323525	3	4	119	1	0	0	0	0	1	0	0	0	834	643	23	2	1008	2	AQPEP	5	115323525	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	50785586	115323525	65591735	32	35742										
PCDHGA2	56113	broad.mit.edu	37	chr5	140718896	140718896	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aattgactatttattcagtaGaggtggaaataacagatatt	8	3	1	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr5:140718896G>C	uc003ljk.1	+	1	543	c.358G>C	c.(358-360)GAG>CAG	p.E120Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E120Q	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	120	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTATTCAGTAGAGGTGGAAAT	0.458													0	0	0	0.001984	0	5	54										C	140718896	G	C	140718896	3	2	119	1	0	0	0	0	1	0	0	0	11554	943	33	1	360	1	PCDHGA2	5	140718896	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	25395371	140718896	40196364	33	35743										
PCDHGB2	56103	broad.mit.edu	37	chr5	140740084	140740084	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	taattgtgcaggatataaatGataataccccgctattcaaa	6	7	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr5:140740084G>A	uc003ljs.1	+	1	382	c.382G>A	c.(382-384)GAT>AAT	p.D128N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.D128N	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	128	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATATAAATGATAATACCCC	0.398													0	0	0	0.00245	0	14	29										A	140740084	G	A	140740084	3	1	119	1	0	0	0	0	1	0	0	0	11563	1290	45	1	384	1	PCDHGB2	5	140740084	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	21188	140740084	40175176	34	35744										
FAM8A1	51439	broad.mit.edu	37	chr6	17601039	17601039	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ggctacctcacctggcacagCggcctggccgccttcccagc	11	19	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr6:17601039C>T	uc003ncc.2	+	1	522	c.399C>T	c.(397-399)AGC>AGT	p.S133S		NM_016255	NP_057339	Q9UBU6	FA8A1_HUMAN	family with sequence similarity 8, member A1	133						integral to membrane					0	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)			CCTGGCACAGCGGCCTGGCCG	0.637													0	0	0	0.00245	0	12	49										T	17601039	C	T	17601039	2	4	119	1	0	0	0	0	0	0	0	1	5649	767	27	2		2	FAM8A1	6	17601039	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		17601039	153514028	35	35745										
HIST1H2AC	8334	broad.mit.edu	37	chr6	26124513	26124513	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tcgcgccaaagcgaaatcccGctcttctcgcgctggtctcc	9	17	3	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr6:26124513G>C	uc003ngm.2	+	1	141	c.53G>C	c.(52-54)CGC>CCC	p.R18P	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.R18P	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	18					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCGAAATCCCGCTCTTCTCGC	0.597													0	0	0	0.006122	0	13	38										C	26124513	G	C	26124513	3	2	119	1	0	0	0	0	1	0	0	0	7130	1087	38	4	55	4	HIST1H2AC	6	26124513	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	8523474	26124513	144990554	36	35746										
C6orf142	90523	broad.mit.edu	37	chr6	53989534	53989534	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ggcaccgcagctgtccggccCaagtctctagctatctcgtc	10	16	2	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr6:53989534C>A	uc003pcg.3	+	3	596	c.483C>A	c.(481-483)CCC>CCA	p.P161P	C6orf142_uc003pcf.2_Silent_p.P161P|C6orf142_uc003pch.3_Silent_p.P99P|C6orf142_uc011dwz.1_Silent_p.P120P|C6orf142_uc011dxa.1_Silent_p.P172P	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	161						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CTGTCCGGCCCAAGTCTCTAG	0.527													1	0	1.75199e-13	0.007291	2.24526e-13	23	68										A	53989534	C	A	53989534	2	1	119	1	0	0	0	0	0	0	0	1	2333	581	21	4		4	C6orf142	6	53989534	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	27865021	53989534	117125533	37	35747										
C6orf182	285753	broad.mit.edu	37	chr6	109484117	109484117	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acagcagctttcatccaataCgagttcataatcttcaaatg	5	10	4	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr6:109484117C>T	uc010kdk.2	+	13	1904	c.1327C>T	c.(1327-1329)CGA>TGA	p.R443*	C6orf182_uc003psx.3_3'UTR|C6orf182_uc010kdl.2_Nonsense_Mutation_p.R443*|C6orf182_uc003psy.3_Nonsense_Mutation_p.R443*	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753	443						microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		TCATCCAATACGAGTTCATAA	0.358													0	0	0	0.001168	0	6	30										T	109484117	C	T	109484117	4	4	119	1	0	0	0	0	0	1	0	0	2346	528	19	2	1365	2	C6orf182	6	109484117	Nonsense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	55494583	109484117	61630950	38	35748										
THBS2	7058	broad.mit.edu	37	chr6	169632172	169632172	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cgcagatgagcccgtcgcccGcgtagcctgtctggcactcg	13	16	1	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr6:169632172G>A	uc003qwt.2	-	14	2302	c.2054C>T	c.(2053-2055)GCG>GTG	p.A685V		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	685	EGF-like 3.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCCGTCGCCCGCGTAGCCTGT	0.622													0	0	0	0.012213	0	30	89										A	169632172	G	A	169632172	3	1	119	1	0	0	0	0	1	0	0	0	15851	1087	38	2	1504	2	THBS2	6	169632172	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	60148055	169632172	1482895	39	35749										
SCIN	85477	broad.mit.edu	37	chr7	12680101	12680101	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctccccctacacgcctctttCaagtccggagaaacctggca	7	17	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr7:12680101C>G	uc003ssn.3	+	11	1750	c.1540C>G	c.(1540-1542)CAA>GAA	p.Q514E	SCIN_uc010ktt.2_RNA|SCIN_uc003sso.3_Missense_Mutation_p.Q267E	NM_001112706	NP_001106177	Q9Y6U3	ADSV_HUMAN	scinderin isoform 1	514	Ca(2+)-dependent actin binding.				actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ACGCCTCTTTCAAGTCCGGAG	0.458													0	0	0	0.009096	0	3	21										G	12680101	C	G	12680101	3	3	119	1	0	0	0	0	1	0	0	0	13905	827	29	1	1582	1	SCIN	7	12680101	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		12680101	146458562	40	35750										
NFE2L3	9603	broad.mit.edu	37	chr7	26224583	26224584	+	Frame_Shift_Ins	INS	-	-	T													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gattctgattctggcctttcINStttagattcaagtcacaata							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr7:26224583_26224584insT	uc003sxq.2	+	4	1537_1538	c.1265_1266insT	c.(1264-1266)TCTfs	p.S422fs		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	422					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						TCTGGCCTTTCTTTAGATTCAA	0.376																		82	120	---	---								T	26224584	-	T	26224583	7	5	119	1	0	1	1	0	0	0	0	0	10369	913	32	0	1279	0	NFE2L3	7	26224583	Frame_Shift_Ins	INS	-	TCGA-GV-A3QG-01A-11D-A21Z-08	13544482	26224583	132914080	41	35751										
GLI3	2737	broad.mit.edu	37	chr7	42116455	42116456	+	Frame_Shift_Ins	INS	-	-	T													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cagggaaaagatgaggagggINStctgaaaagaagagagagcc							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr7:42116455_42116456insT	uc011kbh.1	-	4	459_460	c.368_369insA	c.(367-369)CACfs	p.H123fs	GLI3_uc011kbg.1_Frame_Shift_Ins_p.H64fs	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	123					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.H123D(1)		lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GATGAGGAGGGTCTGAAAAGAA	0.436									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome									12	45	---	---								T	42116456	-	T	42116455	7	5	119	1	0	1	1	0	0	0	0	0	6439	1275	44	0	4421	0	GLI3	7	42116455	Frame_Shift_Ins	INS	-	TCGA-GV-A3QG-01A-11D-A21Z-08	15891872	42116455	117022208	42	35752										
CNTNAP2	26047	broad.mit.edu	37	chr7	146829367	146829367	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gcttttcttgtgtggaacccTatacggtgcctgtctttttc	9	10	2	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr7:146829367T>A	uc003weu.1	+	8	1630	c.1114T>A	c.(1114-1116)TAT>AAT	p.Y372N		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	372	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGTGGAACCCTATACGGTGCC	0.448										HNSCC(39;0.1)			0	0	0	0.013114	0	37	95										A	146829367	T	A	146829367	3	1	119	1	0	0	0	0	1	0	0	0	3647	1522	53	5	1144	5	CNTNAP2	7	146829367	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	104712912	146829367	12309296	43	35753										
SSPO	23145	broad.mit.edu	37	chr7	149522398	149522398	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gcccaagacactgtattcacCctggactgtgccaaccagtg	9	14	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr7:149522398C>T	uc010lpk.2	+	101	14025	c.14025C>T	c.(14023-14025)ACC>ACT	p.T4675T	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_RNA|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4675	TIL 6.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGTATTCACCCTGGACTGTG	0.637													0	0	0	0.01441	0	67	135										T	149522398	C	T	149522398	2	4	119	1	0	0	0	0	0	0	0	1	15188	623	22	2		2	SSPO	7	149522398	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	2693031	149522398	9616265	44	35754										
DEFA5	1670	broad.mit.edu	37	chr8	6914048	6914048	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gcaagattgatgtctcctacCtgaggttctaagagcagaga	11	8	2	5			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr8:6914048C>A	uc003wra.1	-	1	212	c.172G>T	c.(172-174)GGT>TGT	p.G58C		NM_021010	NP_066290	Q01523	DEF5_HUMAN	defensin, alpha 5 preproprotein	58					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		TGTCTCCTACCTGAGGTTCTA	0.338													1	0	3.07112e-06	0.010729	3.61953e-06	8	77										A	6914048	C	A	6914048	3	1	119	1	0	0	0	0	1	0	0	0	4392	695	24	4	120	4	DEFA5	8	6914048	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		6914048	139449974	45	35755										
PLAT	5327	broad.mit.edu	37	chr8	42045071	42045071	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tagctgatgccctggtcctcGtagcacgtggccctggtatc	12	13	0	1	rs114679748	by1000genomes	TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr8:42045071G>A	uc003xos.2	-	6	593	c.384C>T	c.(382-384)TAC>TAT	p.Y128Y	PLAT_uc010lxf.1_Silent_p.Y45Y|PLAT_uc010lxg.1_Intron|PLAT_uc003xot.2_Silent_p.Y82Y|PLAT_uc011lcm.1_Intron|PLAT_uc011lcn.1_Intron	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	128	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCTGGTCCTCGTAGCACGTGG	0.632													0	0	0	0.00499	0	13	42										A	42045071	G	A	42045071	2	1	119	1	0	0	0	0	0	0	0	1	12021	1140	40	2		2	PLAT	8	42045071	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	35131023	42045071	104318951	46	35756										
HSPA5	3309	broad.mit.edu	37	chr9	127999293	127999293	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tttgttccctgtacccttgtCttcagctgtcactcgaagaa	7	12	3	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr9:127999293C>G	uc004bpn.2	-	8	1799	c.1543G>C	c.(1543-1545)GAC>CAC	p.D515H		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	515					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	GTACCCTTGTCTTCAGCTGTC	0.438										Prostate(1;0.17)			0	0	0	0.01441	0	37	145										G	127999293	C	G	127999293	3	3	119	1	0	0	0	0	1	0	0	0	7414	913	32	1	425	1	HSPA5	9	127999293	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		127999293	13214138	47	35757										
LCN15	389812	broad.mit.edu	37	chr9	139656658	139656658	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acctgactggggcagcatgaCcatcatgtccttggggagcc	13	12	1	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr9:139656658C>T	uc004cjd.2	-	5	527	c.502G>A	c.(502-504)GTC>ATC	p.V168I		NM_203347	NP_976222	Q6UWW0	LCN15_HUMAN	lipocalin 15 precursor	168					lipid metabolic process	extracellular region	binding|transporter activity				0						GGCAGCATGACCATCATGTCC	0.657													0	0	0	0.00308	0	3	8										T	139656658	C	T	139656658	3	4	119	1	0	0	0	0	1	0	0	0	8683	507	18	2	60	2	LCN15	9	139656658	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	11657365	139656658	1556773	48	35758										
WAC	51322	broad.mit.edu	37	chr10	28908493	28908493	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tttttgagacaacaaattaaGgaacttgaaaagctaaaaaa	6	4	0	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:28908493G>A	uc001iuf.2	+	14	1987	c.1902G>A	c.(1900-1902)AAG>AAA	p.K634K	WAC_uc001iud.2_Silent_p.K589K|WAC_uc001iue.2_Silent_p.K324K|WAC_uc001iug.2_Silent_p.K531K|WAC_uc001iuh.2_Silent_p.K585K	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	634	Potential.				cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						AACAAATTAAGGAACTTGAAA	0.318													0	0	0	0.001855	0	11	25										A	28908493	G	A	28908493	2	1	119	1	0	0	0	0	0	0	0	1	17244	991	35	2		2	WAC	10	28908493	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		28908493	106626254	49	35759										
LYZL2	119180	broad.mit.edu	37	chr10	30915167	30915167	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgggctgtggtgttgtagccGctctcataatacgccatgca	12	10	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:30915167G>A	uc001ivk.2	-	3	316	c.303C>T	c.(301-303)AGC>AGT	p.S101S		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	55					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				TGTTGTAGCCGCTCTCATAAT	0.557													0	0	0	0.010504	0	19	50										A	30915167	G	A	30915167	2	1	119	1	0	0	0	0	0	0	0	1	9132	1078	38	2		2	LYZL2	10	30915167	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	2006674	30915167	104619580	50	35760										
TET1	80312	broad.mit.edu	37	chr10	70446227	70446228	+	Frame_Shift_Ins	INS	-	-	A													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	agatgagtttggctccaaggINSaaggaatggaagccaagatc							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:70446227_70446228insA	uc001jok.3	+	11	5672_5673	c.5167_5168insA	c.(5167-5169)GAAfs	p.E1723fs		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1723					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TGGCTCCAAGGAAGGAATGGAA	0.495																		26	88	---	---								A	70446228	-	A	70446227	7	5	119	1	0	1	1	0	0	0	0	0	15766	1175	41	0	5205	0	TET1	10	70446227	Frame_Shift_Ins	INS	-	TCGA-GV-A3QG-01A-11D-A21Z-08	39531060	70446227	65088520	51	35761										
ADK	132	broad.mit.edu	37	chr10	76349059	76349059	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ggaagctgccacttttgctaGagagcaaggctttgaggtga	14	7	0	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:76349059G>C	uc001jwi.2	+	8	818	c.746G>C	c.(745-747)AGA>ACA	p.R249T	ADK_uc010qlb.1_Missense_Mutation_p.R192T|ADK_uc001jwj.2_Missense_Mutation_p.R232T|ADK_uc010qlc.1_Missense_Mutation_p.R214T|ADK_uc001jwl.2_Missense_Mutation_p.R19T	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	249					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	ACTTTTGCTAGAGAGCAAGGC	0.338													0	0	0	0.003163	0	13	67										C	76349059	G	C	76349059	3	2	119	1	0	0	0	0	1	0	0	0	320	942	33	1	794	1	ADK	10	76349059	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	5902832	76349059	59185688	52	35762										
CDHR1	92211	broad.mit.edu	37	chr10	85974343	85974345	+	In_Frame_Del	DEL	AGA	AGA	-													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgagctcaagcaaaagtttgAgaagaagagtgtgcacaaca							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:85974343_85974345delAGA	uc001kcv.2	+	17	2546_2548	c.2546_2548delAGA	c.(2545-2550)GAGAAG>GAG	p.K851del	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_In_Frame_Del_p.K555del|CDHR1_uc001kcx.2_In_Frame_Del_p.K165del	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	851	Cytoplasmic (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CAAAAGTTTGAGAAGAAGAGTGT	0.562											OREG0020334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						27	121	---	---								-	85974345	AGA	-	85974343	7	5	119	1	0	1	0	1	0	0	0	0	3118	304	11	0	2612	0	CDHR1	10	85974343	In_Frame_Del	DEL	AGA	TCGA-GV-A3QG-01A-11D-A21Z-08	9625284	85974343	49560404	53	35763										
GRID1	2894	broad.mit.edu	37	chr10	87487630	87487630	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	accttgctgatgagctccccGatcatcccgttccaggaggt	10	14	1	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:87487630G>T	uc001kdl.1	-	10	1616	c.1515C>A	c.(1513-1515)ATC>ATA	p.I505I	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.I76I	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	505	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGAGCTCCCCGATCATCCCGT	0.532										Multiple Myeloma(13;0.14)			1	0	3.52763e-06	0.00499	4.12077e-06	13	51										T	87487630	G	T	87487630	2	4	119	1	0	0	0	0	0	0	0	1	6771	1048	37	3		3	GRID1	10	87487630	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	1513287	87487630	48047117	54	35764										
SCD	6319	broad.mit.edu	37	chr10	102107836	102107838	+	In_Frame_Del	DEL	ACC	ACC	-													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tccagatctctagctcctatAccaccaccaccaccattaca							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:102107836_102107838delACC	uc001kqy.2	+	2	533_535	c.43_45delACC	c.(43-45)ACCdel	p.T19del		NM_005063	NP_005054	O00767	ACOD_HUMAN	stearoyl-CoA desaturase 1	19	Cytoplasmic (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity				0		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TAGCTCCTATACCACCACCACCA	0.581																		8	229	---	---								-	102107838	ACC	-	102107836	7	5	119	1	0	1	0	1	0	0	0	0	13886	391	14	0	49	0	SCD	10	102107836	In_Frame_Del	DEL	ACC	TCGA-GV-A3QG-01A-11D-A21Z-08	14620206	102107836	33426911	55	35765										
SORCS3	22986	broad.mit.edu	37	chr10	106918731	106918731	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tctctagcaaggagacagccCcaggacttgtggtggctaca	12	11	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:106918731C>A	uc001kyi.1	+	11	1938	c.1711C>A	c.(1711-1713)CCA>ACA	p.P571T		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	571	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGAGACAGCCCCAGGACTTGT	0.383													1	0	1.06961e-07	0.00308	1.28354e-07	7	49										A	106918731	C	A	106918731	3	1	119	1	0	0	0	0	1	0	0	0	14932	623	22	4	1753	4	SORCS3	10	106918731	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	4810895	106918731	28616016	56	35766										
SORCS3	22986	broad.mit.edu	37	chr10	106937850	106937850	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ttttgatgagggccactcttGggacaagtatggtttcactt	11	7	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr10:106937850G>T	uc001kyi.1	+	14	2155	c.1928G>T	c.(1927-1929)TGG>TTG	p.W643L	SORCS3_uc010qqz.1_Intron	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	643	BNR 6.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGCCACTCTTGGGACAAGTAT	0.463													1	0	0.000219431	0.00245	0.000249698	12	54										T	106937850	G	T	106937850	3	4	119	1	0	0	0	0	1	0	0	0	14932	1357	47	4	1982	4	SORCS3	10	106937850	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	19119	106937850	28596897	57	35767										
OR5I1	10798	broad.mit.edu	37	chr11	55703362	55703362	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aatgattaataacatttttgTcacaatatttcagaataaag	4	4	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:55703362T>A	uc010ris.1	-	1	515	c.515A>T	c.(514-516)GAC>GTC	p.D172V		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AACATTTTTGTCACAATATTT	0.428													0	0	0	0.006122	0	17	39										A	55703362	T	A	55703362	3	1	119	1	0	0	0	0	1	0	0	0	11164	1667	58	5	432	5	OR5I1	11	55703362	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08		55703362	79303154	58	35768										
CTSW	1521	broad.mit.edu	37	chr11	65650570	65650570	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gtacctggccacttatggccCcatcaccgtgaccatcaaca	7	16	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:65650570C>T	uc001ogc.1	+	8	818	c.776C>T	c.(775-777)CCC>CTC	p.P259L	CTSW_uc001ogb.1_Missense_Mutation_p.P259L	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	259					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		ACTTATGGCCCCATCACCGTG	0.607													0	0	0	0.01441	0	60	177										T	65650570	C	T	65650570	3	4	119	1	0	0	0	0	1	0	0	0	4042	623	22	2	806	2	CTSW	11	65650570	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	9947208	65650570	69355946	59	35769										
BBS1	582	broad.mit.edu	37	chr11	66297375	66297375	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	caggccctcgagtccagcctGagccccctgtccacgacagc	10	19	0	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:66297375G>A	uc001oij.1	+	14	1437	c.1425G>A	c.(1423-1425)CTG>CTA	p.L475L	BBS1_uc001oii.1_Silent_p.L512L|BBS1_uc010rpg.1_Silent_p.L378L|BBS1_uc001oik.1_Silent_p.L399L|BBS1_uc001oil.1_Silent_p.L346L|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Silent_p.L143L	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	475					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						AGTCCAGCCTGAGCCCCCTGT	0.667									Bardet-Biedl_syndrome				0	0	0	0.001168	0	5	17										A	66297375	G	A	66297375	2	1	119	1	0	0	0	0	0	0	0	1	1335	1277	45	1		1	BBS1	11	66297375	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	646805	66297375	68709141	60	35770										
FAT3	120114	broad.mit.edu	37	chr11	92085844	92085844	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aacagacgcagatattggttCcaatggagaattctactact	8	8	1	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:92085844C>G	uc001pdj.3	+	1	583	c.566C>G	c.(565-567)TCC>TGC	p.S189C		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	189	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GATATTGGTTCCAATGGAGAA	0.408										TCGA Ovarian(4;0.039)			0	0	0	0.004482	0	8	33										G	92085844	C	G	92085844	3	3	119	1	0	0	0	0	1	0	0	0	5691	855	30	1	568	1	FAT3	11	92085844	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	25788469	92085844	42920672	61	35771										
HEPHL1	341208	broad.mit.edu	37	chr11	93844208	93844208	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ccatgctggcatggagacaaCctacacggtccttcgtaaca	9	13	0	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:93844208C>T	uc001pep.2	+	18	3342	c.3185C>T	c.(3184-3186)ACC>ATC	p.T1062I	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	1062	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATGGAGACAACCTACACGGTC	0.512													0	0	0	0.001168	0	5	18										T	93844208	C	T	93844208	3	4	119	1	0	0	0	0	1	0	0	0	7055	507	18	2	3255	2	HEPHL1	11	93844208	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	1758364	93844208	41162308	62	35772										
ATM	472	broad.mit.edu	37	chr11	108188181	108188181	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aaaataaagactggtgtcctGaactagaagaacttcattac	7	7	1	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:108188181G>A	uc001pkb.1	+	43	6665	c.6280G>A	c.(6280-6282)GAA>AAA	p.E2094K	ATM_uc009yxr.1_Missense_Mutation_p.E2094K|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E746K|ATM_uc001pkg.1_Missense_Mutation_p.E451K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2094	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CTGGTGTCCTGAACTAGAAGA	0.378			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.006999	0	35	124										A	108188181	G	A	108188181	3	1	119	1	0	0	0	0	1	0	0	0	1109	1291	45	1	6446	1	ATM	11	108188181	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	14343973	108188181	26818335	63	35773										
ARHGAP32	9743	broad.mit.edu	37	chr11	128839161	128839161	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctgagtgaggtgttcttcctCcttgtagcagtctctggagt	12	9	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr11:128839161C>G	uc009zcp.2	-	22	5905	c.5905G>C	c.(5905-5907)GAG>CAG	p.E1969Q	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.E928Q|ARHGAP32_uc001qez.2_Missense_Mutation_p.E1620Q	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1969	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TGTTCTTCCTCCTTGTAGCAG	0.537													0	0	0	0.00333	0	20	97										G	128839161	C	G	128839161	3	3	119	1	0	0	0	0	1	0	0	0	881	864	30	1	362	1	ARHGAP32	11	128839161	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	20650980	128839161	6167355	64	35774										
NUP107	57122	broad.mit.edu	37	chr12	69121136	69121136	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ttttttcctatgaaggaggaAgtttctattgaagttttaaa	8	3	1	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr12:69121136A>C	uc001suf.2	+	20	1816	c.1701A>C	c.(1699-1701)GAA>GAC	p.E567D	NUP107_uc001sug.2_Missense_Mutation_p.E414D|NUP107_uc010stj.1_Missense_Mutation_p.E538D	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	567					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TGAAGGAGGAAGTTTCTATTG	0.234													0	0	0	0.003163	0	14	61										C	69121136	A	C	69121136	3	2	119	1	0	0	0	0	1	0	0	0	10753	69	3	5	1779	5	NUP107	12	69121136	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08		69121136	64730759	65	35775										
UTP20	27340	broad.mit.edu	37	chr12	101679598	101679598	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgtatcaccaaaacgagataGttcagagtttgaagactcac	8	8	3	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr12:101679598G>T	uc001tia.1	+	4	421	c.265G>T	c.(265-267)GTT>TTT	p.V89F	UTP20_uc009ztz.1_Missense_Mutation_p.V89F	NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	89					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						AAACGAGATAGTTCAGAGTTT	0.358													1	0	3.80469e-20	0.009535	5.0222e-20	30	80										T	101679598	G	T	101679598	3	4	119	1	0	0	0	0	1	0	0	0	17096	1029	36	4	279	4	UTP20	12	101679598	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	32558462	101679598	32172297	66	35776										
CCDC60	160777	broad.mit.edu	37	chr12	119909888	119909888	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aaagaagcaacaacaacttcAgaaactgaaagaggaggaaa	9	6	1	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr12:119909888A>G	uc001txe.2	+	3	725	c.260A>G	c.(259-261)CAG>CGG	p.Q87R	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	87	Potential.									ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		CAACAACTTCAGAAACTGAAA	0.423													0	0	0	0.009535	0	27	99										G	119909888	A	G	119909888	3	3	119	1	0	0	0	0	1	0	0	0	2831	188	7	5	270	5	CCDC60	12	119909888	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	18230290	119909888	13942007	67	35777										
NCOR2	9612	broad.mit.edu	37	chr12	124846735	124846735	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ggggctgctgccaggctgctGaggggcgtcgctctccggct	18	13	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr12:124846735G>A	uc010tba.1	-	22	3154	c.3037C>T	c.(3037-3039)CAG>TAG	p.Q1013*	NCOR2_uc010tay.1_Nonsense_Mutation_p.Q1012*|NCOR2_uc010taz.1_Nonsense_Mutation_p.Q996*|NCOR2_uc010tbb.1_Nonsense_Mutation_p.Q1013*|NCOR2_uc010tbc.1_Nonsense_Mutation_p.Q995*|NCOR2_uc001ugj.1_Nonsense_Mutation_p.Q1013*	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1013					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCAGGCTGCTGAGGGGCGTCG	0.721													0	0	0	0.004482	0	6	18										A	124846735	G	A	124846735	4	1	119	1	0	0	0	0	0	1	0	0	10236	1299	45	1	4635	1	NCOR2	12	124846735	Nonsense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	4936847	124846735	9005160	68	35778										
PDS5B	23047	broad.mit.edu	37	chr13	33315272	33315272	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cagatgaagaagtatctcctGagacaatggtcaaagtgagt	11	6	2	5			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr13:33315272G>C	uc010abf.2	+	22	2619	c.2461G>C	c.(2461-2463)GAG>CAG	p.E821Q	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	821					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGTATCTCCTGAGACAATGGT	0.299													0	0	0	0.00499	0	12	44										C	33315272	G	C	33315272	3	2	119	1	0	0	0	0	1	0	0	0	11692	1291	45	1	2543	1	PDS5B	13	33315272	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		33315272	81854606	69	35779										
NALCN	259232	broad.mit.edu	37	chr13	101944345	101944345	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cttgctgatagcgtacctggGtggtggctgttgaggtagtg	17	6	0	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr13:101944345G>C	uc001vox.1	-	9	1232	c.1043C>G	c.(1042-1044)ACC>AGC	p.T348S	NALCN_uc001voy.2_Missense_Mutation_p.T63S|NALCN_uc001voz.2_Missense_Mutation_p.T348S|NALCN_uc001vpa.2_Missense_Mutation_p.T348S	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	348	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCGTACCTGGGTGGTGGCTGT	0.468													0	0	0	0.006122	0	13	101										C	101944345	G	C	101944345	3	2	119	1	0	0	0	0	1	0	0	0	10148	1261	44	4	4317	4	NALCN	13	101944345	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	68629073	101944345	13225533	70	35780										
SRP54	6729	broad.mit.edu	37	chr14	35480773	35480773	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gagtagagaaatttaaaaatGaaaattttgaaattattatt	6	0	0	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr14:35480773G>A	uc001wso.2	+	8	895	c.544G>A	c.(544-546)GAA>AAA	p.E182K	SRP54_uc010tpp.1_Missense_Mutation_p.E133K|SRP54_uc010tpq.1_Missense_Mutation_p.E118K	NM_003136	NP_003127	P61011	SRP54_HUMAN	signal recognition particle 54kDa isoform 1	182	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		ATTTAAAAATGAAAATTTTGA	0.313													0	0	0	0.008361	0	25	72										A	35480773	G	A	35480773	3	1	119	1	0	0	0	0	1	0	0	0	15154	1291	45	1	570	1	SRP54	14	35480773	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		35480773	71868767	71	35781										
NIN	51199	broad.mit.edu	37	chr14	51206189	51206189	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gccctgatggatgagtagctAtctctggggcccagctctta	12	11	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr14:51206189A>G	uc001wym.2	-	26	5656	c.5465T>C	c.(5464-5466)ATA>ACA	p.I1822T	NIN_uc001wyi.2_Missense_Mutation_p.I1822T|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.I1109T|NIN_uc010tqp.1_Missense_Mutation_p.I1828T|NIN_uc001wyo.2_Missense_Mutation_p.I1822T|NIN_uc001wyn.2_RNA	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1822					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					ATGAGTAGCTATCTCTGGGGC	0.463			T	PDGFRB	MPD								0	0	0	0.006122	0	15	47										G	51206189	A	G	51206189	3	3	119	1	0	0	0	0	1	0	0	0	10417	449	16	5	1108	5	NIN	14	51206189	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	15725416	51206189	56143351	72	35782										
SIX4	51804	broad.mit.edu	37	chr14	61186531	61186531	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gcagtggagagaatccaatgCtcccattaaggaactggctg	12	9	0	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr14:61186531C>T	uc001xfc.2	-	2	1496	c.1496G>A	c.(1495-1497)AGC>AAC	p.S499N	SIX4_uc010app.1_Missense_Mutation_p.S491N	NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	499						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GAATCCAATGCTCCCATTAAG	0.478													0	0	0	0.004656	0	20	84										T	61186531	C	T	61186531	3	4	119	1	0	0	0	0	1	0	0	0	14349	797	28	2	857	2	SIX4	14	61186531	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	9980342	61186531	46163009	73	35783										
PCNX	22990	broad.mit.edu	37	chr14	71568799	71568800	+	Frame_Shift_Ins	INS	-	-	T													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acctcgtaatagcccatgaaINSggggaccctgcatggcggag							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr14:71568799_71568800insT	uc001xmo.2	+	31	6128_6129	c.5682_5683insT	c.(5680-5685)GAAGGGfs	p.E1894fs	PCNX_uc010are.1_Frame_Shift_Ins_p.E1783fs|PCNX_uc010arf.1_Frame_Shift_Ins_p.E682fs|PCNX_uc001xmp.2_Translation_Start_Site	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1894_1895						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TAGCCCATGAAGGGGACCCTGC	0.45																		25	240	---	---								T	71568800	-	T	71568799	7	5	119	1	0	1	1	0	0	0	0	0	11591	69	3	0	5804	0	PCNX	14	71568799	Frame_Shift_Ins	INS	-	TCGA-GV-A3QG-01A-11D-A21Z-08	10382268	71568799	35780741	74	35784										
GOLGA5	9950	broad.mit.edu	37	chr14	93299497	93299497	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aaactttaagcaatagcagtCagtctgagttagaaaatcga	8	6	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr14:93299497C>A	uc001yaz.1	+	10	1932	c.1750C>A	c.(1750-1752)CAG>AAG	p.Q584K	GOLGA5_uc001yba.1_5'UTR	NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	584	Cytoplasmic (Potential).|Potential.			QS -> PV (in Ref. 8; CAB36967).	Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CAATAGCAGTCAGTCTGAGTT	0.378			T	RET	papillary thyroid								1	0	2.48696e-23	0.003271	3.31594e-23	26	79										A	93299497	C	A	93299497	3	1	119	1	0	0	0	0	1	0	0	0	6556	827	29	3	1784	3	GOLGA5	14	93299497	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	21730698	93299497	14050043	75	35785										
DICER1	23405	broad.mit.edu	37	chr14	95560364	95560364	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ccagcgatgcaaagatggtgTtgttgaccagggcagaccgc	14	10	0	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr14:95560364T>C	uc001ydw.2	-	25	5407	c.5225A>G	c.(5224-5226)AAC>AGC	p.N1742S	DICER1_uc010avh.1_Missense_Mutation_p.N640S|DICER1_uc001ydv.2_Missense_Mutation_p.N1732S|DICER1_uc001ydx.2_Missense_Mutation_p.N1742S	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1742	RNase III 2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AAAGATGGTGTTGTTGACCAG	0.512			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.013726	0	27	51										C	95560364	T	C	95560364	3	2	119	1	0	0	0	0	1	0	0	0	4521	1725	60	5	559	5	DICER1	14	95560364	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	2260867	95560364	11789176	76	35786										
TLN2	83660	broad.mit.edu	37	chr15	62939540	62939540	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgtccttaaagatttgtgtgCgccactgcaacgtggtgaag	12	8	0	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr15:62939540C>T	uc002alb.3	+	1	31	c.31C>T	c.(31-33)CGC>TGC	p.R11C	MGC15885_uc010uib.1_5'Flank|MGC15885_uc002ala.3_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	11					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GATTTGTGTGCGCCACTGCAA	0.488													0	0	0	0.008361	0	26	84										T	62939540	C	T	62939540	3	4	119	1	0	0	0	0	1	0	0	0	15945	768	27	2	33	2	TLN2	15	62939540	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		62939540	39591852	77	35787										
IREB2	3658	broad.mit.edu	37	chr15	78780657	78780657	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tagcaggcacagtgaatataGatttccagacagaaccttta	8	8	0	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr15:78780657G>A	uc002bdr.2	+	15	2092	c.1930G>A	c.(1930-1932)GAT>AAT	p.D644N	IREB2_uc010unb.1_Missense_Mutation_p.D394N	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	644							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AGTGAATATAGATTTCCAGAC	0.363													0	0	0	0.012319	0	17	77										A	78780657	G	A	78780657	3	1	119	1	0	0	0	0	1	0	0	0	7826	942	33	1	1988	1	IREB2	15	78780657	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	15841117	78780657	23750735	78	35788										
KIAA1024	23251	broad.mit.edu	37	chr15	79750503	79750503	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acgcacacagtggctcccacGgacccaaactagagaacaac	8	15	0	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr15:79750503G>A	uc002bew.1	+	2	2089	c.2014G>A	c.(2014-2016)GGA>AGA	p.G672R	KIAA1024_uc010unk.1_Missense_Mutation_p.G672R	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	672						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TGGCTCCCACGGACCCAAACT	0.547													0	0	0	0.01441	0	100	236										A	79750503	G	A	79750503	3	1	119	1	0	0	0	0	1	0	0	0	8205	1117	39	2	2016	2	KIAA1024	15	79750503	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	969846	79750503	22780889	79	35789										
HDGFRP3	50810	broad.mit.edu	37	chr15	83876119	83876119	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gggtagcccttcatcttggcGaagaccaggtcgcccgcttt	12	13	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr15:83876119G>A	uc002bjs.1	-	1	203	c.48C>T	c.(46-48)TTC>TTT	p.F16F		NM_016073	NP_057157	Q9Y3E1	HDGR3_HUMAN	hepatoma-derived growth factor, related protein	16	PWWP.				cell proliferation	nucleus	growth factor activity				0						TCATCTTGGCGAAGACCAGGT	0.582													0	0	0	0.009096	0	3	16										A	83876119	G	A	83876119	2	1	119	1	0	0	0	0	0	0	0	1	7021	1049	37	1		1	HDGFRP3	15	83876119	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	4125616	83876119	18655273	80	35790										
CREBBP	1387	broad.mit.edu	37	chr16	3807992	3807992	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctcttggtattgccctgtgtCcagcttccgcttgatggtgg	12	11	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr16:3807992C>G	uc002cvv.2	-	18	3631	c.3427G>C	c.(3427-3429)GAC>CAC	p.D1143H	CREBBP_uc002cvw.2_Missense_Mutation_p.D1105H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1143	Bromo.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCCCTGTGTCCAGCTTCCGC	0.463			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.010729	0	9	31										G	3807992	C	G	3807992	3	3	119	1	0	0	0	0	1	0	0	0	3861	855	30	1	3957	1	CREBBP	16	3807992	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		3807992	86546761	81	35791										
ACSM5	54988	broad.mit.edu	37	chr16	20432694	20432694	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gtcgagcactcccagagcagCtacggactgggttttgtggc	14	11	0	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr16:20432694C>A	uc002dhe.2	+	5	885	c.738C>A	c.(736-738)AGC>AGA	p.S246R		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	246					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CCCAGAGCAGCTACGGACTGG	0.408													1	0	0.00829132	0.008291	0.00927503	9	33										A	20432694	C	A	20432694	3	1	119	1	0	0	0	0	1	0	0	0	187	796	28	4	752	4	ACSM5	16	20432694	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	16624702	20432694	69922059	82	35792										
SLC12A3	6559	broad.mit.edu	37	chr16	56920342	56920342	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctggtggactttgtgggcacCttcacccggaacctcagcct	11	14	2	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr16:56920342C>G	uc010ccm.2	+	16	2021	c.1992C>G	c.(1990-1992)ACC>ACG	p.T664T	SLC12A3_uc002ekd.3_Silent_p.T664T|SLC12A3_uc010ccn.2_Silent_p.T663T	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	664	Helical; (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TTGTGGGCACCTTCACCCGGA	0.572													0	0	0	0.004007	0	12	100										G	56920342	C	G	56920342	2	3	119	1	0	0	0	0	0	0	0	1	14384	668	24	4		4	SLC12A3	16	56920342	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	36487648	56920342	33434411	83	35793										
PRMT7	54496	broad.mit.edu	37	chr16	68349908	68349908	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gatcttctgcagtcgggccaAtccgaccacggggtctgtgg	14	12	3	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr16:68349908A>G	uc002evy.1	+	3	302	c.26A>G	c.(25-27)AAT>AGT	p.N9S	PRMT7_uc002evx.1_Missense_Mutation_p.N9S|PRMT7_uc010vlg.1_Missense_Mutation_p.N9S	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	9					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		AGTCGGGCCAATCCGACCACG	0.532													0	0	0	0.012319	0	13	53										G	68349908	A	G	68349908	3	3	119	1	0	0	0	0	1	0	0	0	12541	101	4	5	28	5	PRMT7	16	68349908	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	11429566	68349908	22004845	84	35794										
SPIRE2	84501	broad.mit.edu	37	chr16	89916779	89916779	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gctggacgagagcgaggagcGcgaactcagccctcagctgg	16	12	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr16:89916779G>A	uc002foz.1	+	3	408	c.356G>A	c.(355-357)CGC>CAC	p.R119H	SPIRE2_uc010civ.1_Missense_Mutation_p.R34H|SPIRE2_uc010ciw.1_Missense_Mutation_p.R119H|SPIRE2_uc002fpa.1_Missense_Mutation_p.R71H|SPIRE2_uc010cix.1_5'UTR	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	119	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		AGCGAGGAGCGCGAACTCAGC	0.701													0	0	0	0.00308	0	6	13										A	89916779	G	A	89916779	3	1	119	1	0	0	0	0	1	0	0	0	15071	1087	38	2	366	2	SPIRE2	16	89916779	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	21566871	89916779	437974	85	35795										
PRDM7	11105	broad.mit.edu	37	chr16	90127012	90127012	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	caggttctgctcttcatcatCccgggcacagttcacatacc	7	15	5	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr16:90127012C>A	uc010cje.2	-	9	990	c.970G>T	c.(970-972)GAT>TAT	p.D324Y	PRDM7_uc002fqo.2_Intron|PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjg.1_Missense_Mutation_p.D118Y	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	324	SET.					chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TCTTCATCATCCCGGGCACAG	0.542													1	0	4.68919e-08	0.008291	5.67865e-08	8	92										A	90127012	C	A	90127012	3	1	119	1	0	0	0	0	1	0	0	0	12461	855	30	3	516	3	PRDM7	16	90127012	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	210233	90127012	227741	86	35796										
DPH1	1801	broad.mit.edu	37	chr17	1939321	1939321	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	acctacggggcttgctgtgtGgatgacttcacagcgagggc	15	10	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr17:1939321G>T	uc002fts.2	+	4	369	c.351G>T	c.(349-351)GTG>GTT	p.V117V	DPH1_uc002ftr.1_RNA|DPH1_uc002ftt.2_Silent_p.V112V|DPH1_uc010cjx.2_Intron|DPH1_uc010vqs.1_Silent_p.V127V|DPH1_uc002ftu.2_5'Flank|DPH1_uc002ftv.2_5'Flank	NM_001383	NP_001374	Q9BZG8	DPH1_HUMAN	diptheria toxin resistance protein required for	117					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				pancreas(1)	1						CTTGCTGTGTGGATGACTTCA	0.652													1	0	0.00316338	0.003163	0.00356894	13	79										T	1939321	G	T	1939321	2	4	119	1	0	0	0	0	0	0	0	1	4719	1335	47	4		4	DPH1	17	1939321	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		1939321	79255889	87	35797										
AKAP10	11216	broad.mit.edu	37	chr17	19880956	19880956	+	Frame_Shift_Del	DEL	G	G	-													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cgggtcgggacggagggtgcGgggggactggcgcggggagg							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr17:19880956delG	uc002gwo.2	-	1	174	c.37delC	c.(37-39)CGCfs	p.R13fs	AKAP10_uc002gwp.1_Frame_Shift_Del_p.R13fs|AKAP10_uc010cqw.1_Frame_Shift_Del_p.R13fs|AKAP10_uc010vze.1_5'UTR	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	13					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CGGAGGGTGCGGGGGGACTGG	0.746																		2	4	---	---								-	19880956	G	-	19880956	7	5	119	1	0	1	0	1	0	0	0	0	446	1116	39	0	2011	0	AKAP10	17	19880956	Frame_Shift_Del	DEL	G	TCGA-GV-A3QG-01A-11D-A21Z-08	17941635	19880956	61314254	88	35798										
ABCA9	10350	broad.mit.edu	37	chr17	67029998	67029998	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gggcattagaattcacatcaTagtccaaatgtataagctga	8	7	2	2	rs138456095	by1000genomes	TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr17:67029998T>C	uc002jhu.2	-	9	1288	c.1145A>G	c.(1144-1146)TAT>TGT	p.Y382C	ABCA9_uc010dez.2_Missense_Mutation_p.Y382C	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	382					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ATTCACATCATAGTCCAAATG	0.289													0	0	0	0.011902	0	35	149										C	67029998	T	C	67029998	3	2	119	1	0	0	0	0	1	0	0	0	39	1406	49	5	3853	5	ABCA9	17	67029998	Missense_Mutation	SNP	T	TCGA-GV-A3QG-01A-11D-A21Z-08	47149042	67029998	14165212	89	35799										
ABCA6	23460	broad.mit.edu	37	chr17	67079441	67079441	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ggtcaggaggacacctctctCtgtgtttttaacgactgcct	10	11	3	0	rs143326198	by1000genomes	TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr17:67079441C>G	uc002jhw.1	-	35	4562	c.4387G>C	c.(4387-4389)GAG>CAG	p.E1463Q		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1463	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					ACACCTCTCTCTGTGTTTTTA	0.453													0	0	0	0.003271	0	25	48										G	67079441	C	G	67079441	3	3	119	1	0	0	0	0	1	0	0	0	36	922	32	1	486	1	ABCA6	17	67079441	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	49443	67079441	14115769	90	35800										
DSG2	1829	broad.mit.edu	37	chr18	29126318	29126318	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tacagttgtggtcactgaaaGagtaatacagcctcatgggg	12	7	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr18:29126318G>C	uc002kwu.3	+	15	3157	c.2969G>C	c.(2968-2970)AGA>ACA	p.R990T	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	990	Desmoglein repeat 4.|Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			GTCACTGAAAGAGTAATACAG	0.483													0	0	0	0.006214	0	10	27										C	29126318	G	C	29126318	3	2	119	1	0	0	0	0	1	0	0	0	4777	942	33	1	3027	1	DSG2	18	29126318	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08		29126318	48950930	91	35801										
PIK3C3	5289	broad.mit.edu	37	chr18	39607448	39607448	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	agatcaagatactcagcagaGagatccaaagacccatgaga	9	9	2	6			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr18:39607448G>A	uc002lap.2	+	14	1584	c.1526G>A	c.(1525-1527)AGA>AAA	p.R509K	PIK3C3_uc010xcl.1_Missense_Mutation_p.R446K|PIK3C3_uc002laq.2_5'UTR	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	509					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						ACTCAGCAGAGAGATCCAAAG	0.328										TSP Lung(28;0.18)			0	0	0	0.001984	0	6	71										A	39607448	G	A	39607448	3	1	119	1	0	0	0	0	1	0	0	0	11912	942	33	1	1580	1	PIK3C3	18	39607448	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	10481130	39607448	38469800	92	35802										
MALT1	10892	broad.mit.edu	37	chr18	56414989	56414989	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cgctcaccatgcttcatgtcAttttagtagaagtaatgtgc	8	9	3	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr18:56414989A>G	uc002lhm.1	+	17	2648	c.2390A>G	c.(2389-2391)CAT>CGT	p.H797R	MALT1_uc002lhn.1_Missense_Mutation_p.H786R	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	797					activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						GCTTCATGTCATTTTAGTAGA	0.398			T	BIRC3	MALT								0	0	0	0.01441	0	49	170										G	56414989	A	G	56414989	3	3	119	1	0	0	0	0	1	0	0	0	9202	217	8	5	2456	5	MALT1	18	56414989	Missense_Mutation	SNP	A	TCGA-GV-A3QG-01A-11D-A21Z-08	16807541	56414989	21662259	93	35803										
TMEM146	257062	broad.mit.edu	37	chr19	5727329	5727329	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cgcttgattaaacatccttgCgagaaaaatatagcactata	6	8	0	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr19:5727329C>A	uc002mda.2	+	3	238	c.177C>A	c.(175-177)TGC>TGA	p.C59*	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	59	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						AACATCCTTGCGAGAAAAATA	0.328													1	0	1.17739e-12	0.005443	1.49438e-12	25	78										A	5727329	C	A	5727329	4	1	119	1	0	0	0	0	0	1	0	0	16057	776	27	4	187	4	TMEM146	19	5727329	Nonsense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		5727329	53401654	94	35804										
ATP4A	495	broad.mit.edu	37	chr19	36054349	36054351	+	In_Frame_Del	DEL	CTT	CTT	-													0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ttgccacccccgccacccgcCttcttcttcttgctcatctt							TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr19:36054349_36054351delCTT	uc002oal.1	-	2	120_122	c.91_93delAAG	c.(91-93)AAGdel	p.K31del		NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	31	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CGCCACCCGCCTTCTTCTTCTTG	0.601																		7	555	---	---								-	36054351	CTT	-	36054349	7	5	119	1	0	1	0	1	0	0	0	0	1145	680	24	0	3098	0	ATP4A	19	36054349	In_Frame_Del	DEL	CTT	TCGA-GV-A3QG-01A-11D-A21Z-08	30327020	36054349	23074634	95	35805										
GIPR	2696	broad.mit.edu	37	chr19	46180989	46180989	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tgctgggagcgcaacgaagtCaaggccatttggtggattat	14	7	1	0			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr19:46180989C>G	uc002pcu.1	+	10	975	c.876C>G	c.(874-876)GTC>GTG	p.V292V	GIPR_uc002pct.1_Silent_p.V292V|GIPR_uc010xxp.1_Silent_p.V256V|GIPR_uc010xxq.1_Intron	NM_000164	NP_000155	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	292	Extracellular (Potential).				generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		GCAACGAAGTCAAGGCCATTT	0.562													0	0	0	0.01441	0	60	249										G	46180989	C	G	46180989	2	3	119	1	0	0	0	0	0	0	0	1	6395	813	29	1		1	GIPR	19	46180989	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	10126640	46180989	12947994	96	35806										
PLA2G4C	8605	broad.mit.edu	37	chr19	48601511	48601511	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	atattggacaaatgagactcCggcagctttgggagaaggtg	14	6	0	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr19:48601511C>T	uc002phx.2	-	6	851	c.453G>A	c.(451-453)CCG>CCA	p.P151P	PLA2G4C_uc002phw.2_Silent_p.P86P|PLA2G4C_uc010elr.2_Silent_p.P151P|PLA2G4C_uc010xzd.1_Silent_p.P161P|PLA2G4C_uc002phy.3_Silent_p.P151P	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	151	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		AATGAGACTCCGGCAGCTTTG	0.498													0	0	0	0.009096	0	4	47										T	48601511	C	T	48601511	2	4	119	1	0	0	0	0	0	0	0	1	12003	639	23	2		2	PLA2G4C	19	48601511	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	2420522	48601511	10527472	97	35807										
HSD17B14	51171	broad.mit.edu	37	chr19	49316806	49316806	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gtccagatgtttcctggggaGatactagaggaagggagagg	17	5	0	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr19:49316806G>A	uc002pkv.1	-	8	812	c.546C>T	c.(544-546)ATC>ATT	p.I182I	BCAT2_uc002pkq.3_5'Flank|BCAT2_uc002pkr.2_5'Flank|BCAT2_uc002pks.2_5'Flank|BCAT2_uc002pkt.2_5'Flank|BCAT2_uc010emh.1_5'Flank|BCAT2_uc010emi.1_5'Flank|BCAT2_uc010emj.1_5'Flank|HSD17B14_uc010emk.1_Intron	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	182					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		TTCCTGGGGAGATACTAGAGG	0.607													0	0	0	0.001984	0	6	28										A	49316806	G	A	49316806	2	1	119	1	0	0	0	0	0	0	0	1	7383	932	33	1		1	HSD17B14	19	49316806	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	715295	49316806	9812177	98	35808										
MBOAT7	79143	broad.mit.edu	37	chr19	54692102	54692102	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ctgaatgagggcccaggtccCgaggatggtgaccagagaat	15	9	0	4			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr19:54692102C>A	uc002qdq.2	-	4	441	c.175G>T	c.(175-177)GGG>TGG	p.G59W	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Missense_Mutation_p.G41W|MBOAT7_uc002qdr.2_Missense_Mutation_p.G59W|MBOAT7_uc002qds.2_Missense_Mutation_p.R28L|MBOAT7_uc010yen.1_Missense_Mutation_p.R28L|MBOAT7_uc002qdt.3_Missense_Mutation_p.G59W|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	59	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCCAGGTCCCGAGGATGGTG	0.622													1	0	3.67414e-24	0.012213	4.94884e-24	25	100										A	54692102	C	A	54692102	3	1	119	1	0	0	0	0	1	0	0	0	9358	652	23	4	1271	4	MBOAT7	19	54692102	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	5375296	54692102	4436881	99	35809										
SIRPB2	284759	broad.mit.edu	37	chr20	1460373	1460373	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	agcactgaggtgccttcatcCgatttcatttctgagtgttc	9	10	3	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr20:1460373C>T	uc002wfg.2	-	2	651	c.423G>A	c.(421-423)TCG>TCA	p.S141S	SIRPB2_uc002wfh.3_Intron|SIRPB2_uc010zpr.1_Silent_p.S3S	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	141	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane					0						TGCCTTCATCCGATTTCATTT	0.478													0	0	0	0.01441	0	79	192										T	1460373	C	T	1460373	2	4	119	1	0	0	0	0	0	0	0	1	14334	639	23	2		2	SIRPB2	20	1460373	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		1460373	61565147	100	35810										
ITCH	83737	broad.mit.edu	37	chr20	33028050	33028050	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aaatacaaatacaaatacatCtgaaggagcaacatctggat	6	7	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr20:33028050C>A	uc010geu.1	+	10	1085	c.893C>A	c.(892-894)TCT>TAT	p.S298Y	ITCH_uc002xak.2_Missense_Mutation_p.S257Y|ITCH_uc010zuj.1_Missense_Mutation_p.S147Y	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	298					apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						ACAAATACATCTGAAGGAGCA	0.448													1	0	2.35188e-11	0.006122	2.90139e-11	17	59										A	33028050	C	A	33028050	3	1	119	1	0	0	0	0	1	0	0	0	7868	913	32	3	796	3	ITCH	20	33028050	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	31567677	33028050	29997470	101	35811										
C20orf132	140699	broad.mit.edu	37	chr20	35743603	35743603	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	aataaggagaacagggtcctCatcatggcagccagggtagt	13	8	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr20:35743603C>T	uc010zvu.1	-	21	2629	c.2538G>A	c.(2536-2538)ATG>ATA	p.M846I	C20orf132_uc002xgk.2_Missense_Mutation_p.M468I	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:Variant_position_missing_in_Q9H579_after_alignment											0		Myeloproliferative disorder(115;0.00878)				ACAGGGTCCTCATCATGGCAG	0.458													0	0	0	0.001984	0	7	60										T	35743603	C	T	35743603	3	4	119	1	0	0	0	0	1	0	0	0	2086	826	29	1	644	1	C20orf132	20	35743603	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	2715553	35743603	27281917	102	35812										
SMTN	6525	broad.mit.edu	37	chr22	31486843	31486843	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	tccctgtcggtgctcagcccCcgccaaccagcccagaaccg	9	20	1	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr22:31486843C>T	uc003ajl.1	+	9	1133	c.915C>T	c.(913-915)CCC>CCT	p.P305P	SMTN_uc003ajk.1_Silent_p.P305P|SMTN_uc003ajm.1_Silent_p.P305P|SMTN_uc011ale.1_Silent_p.P359P|SMTN_uc011alf.1_Silent_p.P361P|SMTN_uc003ajn.1_Silent_p.P297P|SMTN_uc011alg.1_5'Flank|SMTN_uc003ajo.1_5'Flank|SMTN_uc011alh.1_5'Flank|SMTN_uc010gwe.1_5'Flank	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	305					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						TGCTCAGCCCCCGCCAACCAG	0.622													0	0	0	0.01441	0	71	177										T	31486843	C	T	31486843	2	4	119	1	0	0	0	0	0	0	0	1	14814	610	22	2		2	SMTN	22	31486843	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		31486843	19817723	103	35813										
DEPDC5	9681	broad.mit.edu	37	chr22	32239701	32239701	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cccactcagactcagagttcGtctcctgctgggtggaattc	10	13	3	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr22:32239701G>A	uc003als.2	+	29	2819	c.2677G>A	c.(2677-2679)GTC>ATC	p.V893I	DEPDC5_uc011als.1_Missense_Mutation_p.V824I|DEPDC5_uc011alu.1_Missense_Mutation_p.V902I|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.V893I|DEPDC5_uc003alu.2_Missense_Mutation_p.V342I|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.V223I|DEPDC5_uc003alw.2_Missense_Mutation_p.V191I|DEPDC5_uc011alx.1_Intron|DEPDC5_uc010gwk.2_5'Flank	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	893					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CTCAGAGTTCGTCTCCTGCTG	0.498													0	0	0	0.01441	0	47	103										A	32239701	G	A	32239701	3	1	119	1	0	0	0	0	1	0	0	0	4442	1145	40	2	2805	2	DEPDC5	22	32239701	Missense_Mutation	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	752858	32239701	19064865	104	35814										
ENTHD1	150350	broad.mit.edu	37	chr22	40161511	40161511	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	ttttctaaaggtgtttccaaGaggttttctgtgacagtatt	9	5	2	2			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chr22:40161511G>A	uc003ayg.2	-	6	1187	c.936C>T	c.(934-936)CTC>CTT	p.L312L		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	312										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GTGTTTCCAAGAGGTTTTCTG	0.413													0	0	0	0.01441	0	41	128										A	40161511	G	A	40161511	2	1	119	1	0	0	0	0	0	0	0	1	5137	929	33	1		1	ENTHD1	22	40161511	Silent	SNP	G	TCGA-GV-A3QG-01A-11D-A21Z-08	7921810	40161511	11143055	105	35815										
FRMPD4	9758	broad.mit.edu	37	chrX	12736410	12736410	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	cgcttcttaactgacgtgacCtgtgcatcttcagccaaaga	8	12	3	3			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chrX:12736410C>T	uc004cuz.1	+	16	3971	c.3465C>T	c.(3463-3465)ACC>ACT	p.T1155T	FRMPD4_uc011mij.1_Silent_p.T1147T	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1155					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CTGACGTGACCTGTGCATCTT	0.562													0	0	0	0.01441	0	60	52										T	12736410	C	T	12736410	2	4	119	1	0	0	0	0	0	0	0	1	6059	668	24	2		2	FRMPD4	23	12736410	Silent	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08		12736410	142534150	106	35816										
ZNF645	158506	broad.mit.edu	37	chrX	22291514	22291514	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.214953271028037	23	2.56196112139054e-05	2.48536184210526	3.64699835526316	2.0629485645933	0.256254350060281	0.444174206771154	14	gcttacaggctcatatcaaaCgccgccataagagagctcga	9	12	2	1			TCGA-GV-A3QG-01A-11D-A21Z-08	TCGA-GV-A3QG-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90534196-b1d8-4054-b4d5-1d29943b52bc	124003ae-aa1c-48a9-aecb-38b6995d8d27	g.chrX:22291514C>T	uc004dai.1	+	1	455	c.406C>T	c.(406-408)CGC>TGC	p.R136C		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	136	C2H2-type.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						TCATATCAAACGCCGCCATAA	0.438													0	0	0	0.013537	0	11	22										T	22291514	C	T	22291514	3	4	119	1	0	0	0	0	1	0	0	0	18058	536	19	2	408	2	ZNF645	23	22291514	Missense_Mutation	SNP	C	TCGA-GV-A3QG-01A-11D-A21Z-08	9555104	22291514	132979046	107	35817										
EPHA2	1969	broad.mit.edu	37	chr1	16464437	16464437	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggcctccacggtgaaggtgTagttcatgtggggctccagg	17	9	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:16464437T>C	uc001aya.1	-	5	1360	c.1223A>G	c.(1222-1224)TAC>TGC	p.Y408C	EPHA2_uc010oca.1_Missense_Mutation_p.Y408C	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	408	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGTGAAGGTGTAGTTCATGTG	0.627													0	0	0	0.00361	0	46	36										C	16464437	T	C	16464437	3	2	120	1	0	0	0	0	1	0	0	0	5167	1638	57	5	1759	5	EPHA2	1	16464437	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08		16464437	232786184	1	35818										
ARHGEF10L	55160	broad.mit.edu	37	chr1	17939589	17939589	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctaggctaaaggagagatacGccaggactaagagagacatc	12	8	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:17939589G>A	uc001ban.2	+	8	805	c.646G>A	c.(646-648)GCC>ACC	p.A216T	ARHGEF10L_uc009vpe.1_Intron|ARHGEF10L_uc001bao.2_Intron|ARHGEF10L_uc001bap.2_Intron|ARHGEF10L_uc010ocr.1_Intron|ARHGEF10L_uc001baq.2_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	216					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GGAGAGATACGCCAGGACTAA	0.547													0	0	0	0.002836	0	28	126										A	17939589	G	A	17939589	3	1	120	1	0	0	0	0	1	0	0	0	895	1087	38	2	672	2	ARHGEF10L	1	17939589	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1475152	17939589	231311032	2	35819										
EIF4G3	8672	broad.mit.edu	37	chr1	21186926	21186926	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttgctggaccttcctttgctCttcttgttcttctattttag	6	10	4	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:21186926C>G	uc001bec.2	-	19	3284	c.3028G>C	c.(3028-3030)GAG>CAG	p.E1010Q	EIF4G3_uc010odi.1_Missense_Mutation_p.E614Q|EIF4G3_uc010odj.1_Missense_Mutation_p.E1009Q|EIF4G3_uc009vpz.2_Missense_Mutation_p.E730Q|EIF4G3_uc001bed.2_Missense_Mutation_p.E1010Q|EIF4G3_uc001bef.2_Missense_Mutation_p.E1046Q|EIF4G3_uc001bee.2_Missense_Mutation_p.E1016Q	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1010	eIF3/EIF4A-binding (By similarity).|Potential.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TTCCTTTGCTCTTCTTGTTCT	0.428													0	0	0	0.00361	0	58	63										G	21186926	C	G	21186926	3	3	120	1	0	0	0	0	1	0	0	0	5038	922	32	1	1785	1	EIF4G3	1	21186926	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3247337	21186926	228063695	3	35820										
BAI2	576	broad.mit.edu	37	chr1	32222088	32222088	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctgactccgcctgggccaccGcctcctcggggctaggccgc	13	19	0	1	rs145025368		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:32222088G>A	uc001btn.2	-	4	704	c.350C>T	c.(349-351)GCG>GTG	p.A117V	BAI2_uc010ogp.1_Missense_Mutation_p.A105V|BAI2_uc010ogq.1_Missense_Mutation_p.A117V|BAI2_uc001bto.2_Missense_Mutation_p.A117V|BAI2_uc001btq.1_Missense_Mutation_p.A105V|BAI2_uc010ogr.1_Missense_Mutation_p.A105V	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	117	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CTGGGCCACCGCCTCCTCGGG	0.687													0	0	0	0.004672	0	3	14										A	32222088	G	A	32222088	3	1	120	1	0	0	0	0	1	0	0	0	1299	1087	38	2	4527	2	BAI2	1	32222088	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	11035162	32222088	217028533	4	35821										
CYP4B1	1580	broad.mit.edu	37	chr1	47279201	47279201	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggtaagtcctttgacatcttCtgcgatgtgggtcacatggc	12	9	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:47279201C>G	uc001cqm.3	+	5	627	c.543C>G	c.(541-543)TTC>TTG	p.F181L	CYP4B1_uc009vyl.1_Missense_Mutation_p.F18L|CYP4B1_uc001cqn.3_Missense_Mutation_p.F181L|CYP4B1_uc009vym.2_Missense_Mutation_p.F166L|CYP4B1_uc010omk.1_Missense_Mutation_p.F18L|CYP4B1_uc010oml.1_Missense_Mutation_p.F18L	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	181					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TTGACATCTTCTGCGATGTGG	0.572													0	0	0	0.008871	0	17	80										G	47279201	C	G	47279201	3	3	120	1	0	0	0	0	1	0	0	0	4185	912	32	1	561	1	CYP4B1	1	47279201	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	15057113	47279201	201971420	5	35822										
SLC44A5	204962	broad.mit.edu	37	chr1	75862289	75862289	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaagtcctcttcctcagaggGagtatctgctggtttttcta	9	9	4	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:75862289G>A	uc001dgu.2	-	3	175	c.31C>T	c.(31-33)CCC>TCC	p.P11S	SLC44A5_uc001dgt.2_Missense_Mutation_p.P11S|SLC44A5_uc001dgs.2_5'UTR|SLC44A5_uc001dgr.2_5'UTR|SLC44A5_uc010oqz.1_Missense_Mutation_p.P50S|SLC44A5_uc010ora.1_Intron|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	11	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TCCTCAGAGGGAGTATCTGCT	0.363													0	0	0	0.00361	0	63	51										A	75862289	G	A	75862289	3	1	120	1	0	0	0	0	1	0	0	0	14639	1174	41	1	2327	1	SLC44A5	1	75862289	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	28583088	75862289	173388332	6	35823										
ARHGAP29	9411	broad.mit.edu	37	chr1	94697113	94697113	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgtaatatcagtagagagttGacctgatgcccaagcacgtt	10	8	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:94697113G>C	uc001dqj.3	-	2	424	c.55C>G	c.(55-57)CAA>GAA	p.Q19E	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.Q19E	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	19					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GTAGAGAGTTGACCTGATGCC	0.388													0	0	0	0.005443	0	20	154										C	94697113	G	C	94697113	3	2	120	1	0	0	0	0	1	0	0	0	878	1299	45	1	3818	1	ARHGAP29	1	94697113	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	18834824	94697113	154553508	7	35824										
DBT	1629	broad.mit.edu	37	chr1	100706396	100706396	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaacacacataatttggcttCaaaacatgaacattaccaca	3	10	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:100706396C>A	uc001dta.2	-	2	129	c.96G>T	c.(94-96)TTG>TTT	p.L32F	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	32					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		AATTTGGCTTCAAAACATGAA	0.323													1	0	5.82388e-19	0.00361	6.16791e-19	45	56										A	100706396	C	A	100706396	3	1	120	1	0	0	0	0	1	0	0	0	4258	825	29	3	1392	3	DBT	1	100706396	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	6009283	100706396	148544225	8	35825										
ATP1A1	476	broad.mit.edu	37	chr1	116941293	116941293	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtgaatgactctccagctttGaagaaagcagacattggggt	12	7	1	5			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:116941293G>A	uc001ege.2	+	16	2514	c.2175G>A	c.(2173-2175)TTG>TTA	p.L725L	ATP1A1_uc010owv.1_Silent_p.L694L|ATP1A1_uc010oww.1_Silent_p.L725L|ATP1A1_uc010owx.1_Silent_p.L694L|C1orf203_uc009whb.2_Intron|ATP1A1_uc001egh.2_5'Flank	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	725	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	CTCCAGCTTTGAAGAAAGCAG	0.483													0	0	0	0.004878	0	31	160										A	116941293	G	A	116941293	2	1	120	1	0	0	0	0	0	0	0	1	1128	1281	45	1		1	ATP1A1	1	116941293	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	16234897	116941293	132309328	9	35826										
PDE4DIP	9659	broad.mit.edu	37	chr1	144946680	144946680	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtagcagttgttgtttctccCgagatagctgttctacaagc	10	9	2	1	rs144942272		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:144946680C>T	uc001elw.3	-	5	872	c.581G>A	c.(580-582)CGG>CAG	p.R194Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.R260Q|PDE4DIP_uc001emc.1_Missense_Mutation_p.R194Q|PDE4DIP_uc001emd.1_Missense_Mutation_p.R194Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	194	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTGTTTCTCCCGAGATAGCTG	0.458			T	PDGFRB	MPD								0	0	0	0.004482	0	8	67										T	144946680	C	T	144946680	3	4	120	1	0	0	0	0	1	0	0	0	11643	652	23	2	7758	2	PDE4DIP	1	144946680	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	28005387	144946680	104303941	10	35827										
ECM1	1893	broad.mit.edu	37	chr1	150484939	150484939	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggatgagtgctttgcccgtCgggctccttaccccaactat	11	13	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:150484939C>T	uc001eus.2	+	8	1394	c.1195C>T	c.(1195-1197)CGG>TGG	p.R399W	ECM1_uc001eut.2_Missense_Mutation_p.R274W|ECM1_uc001euu.2_Missense_Mutation_p.R428W|ECM1_uc001euv.2_Missense_Mutation_p.R426W|ECM1_uc009wlu.2_Missense_Mutation_p.R159W	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	399	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTTTGCCCGTCGGGCTCCTTA	0.567													0	0	0	0.00278	0	21	100										T	150484939	C	T	150484939	3	4	120	1	0	0	0	0	1	0	0	0	4897	875	31	1	1225	1	ECM1	1	150484939	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	5538259	150484939	98765682	11	35828										
FLG2	388698	broad.mit.edu	37	chr1	152325463	152325463	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	catgttgagatccggcttggCcgtaagtgtgttctcgtgag	14	8	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:152325463C>T	uc001ezw.3	-	3	4872	c.4799G>A	c.(4798-4800)GGC>GAC	p.G1600D	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1600							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCGGCTTGGCCGTAAGTGTG	0.507													0	0	0	0.00361	0	145	131										T	152325463	C	T	152325463	3	4	120	1	0	0	0	0	1	0	0	0	5923	739	26	2	2380	2	FLG2	1	152325463	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	1840524	152325463	96925158	12	35829										
F5	2153	broad.mit.edu	37	chr1	169510442	169510442	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agtcatatggctgagttctgGagagaggtttgtctggctga	15	5	3	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:169510442G>C	uc001ggg.1	-	13	4031	c.3886C>G	c.(3886-3888)CCA>GCA	p.P1296A		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1296	2-13.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTGAGTTCTGGAGAGAGGTTT	0.522													0	0	0	0.00361	0	151	173										C	169510442	G	C	169510442	3	2	120	1	0	0	0	0	1	0	0	0	5348	1174	41	1	2840	1	F5	1	169510442	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	17184979	169510442	79740179	13	35830										
RYR2	6262	broad.mit.edu	37	chr1	237944916	237944916	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	taatggatctgcagaaggatAtggtggtcatgttgctgtcc	13	6	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:237944916A>T	uc001hyl.1	+	89	12052	c.11932A>T	c.(11932-11934)ATG>TTG	p.M3978L	RYR2_uc010pya.1_Missense_Mutation_p.M393L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3978	Helical; Name=M2; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCAGAAGGATATGGTGGTCAT	0.318													0	0	0	0.000602	0	3	5										T	237944916	A	T	237944916	3	4	120	1	0	0	0	0	1	0	0	0	13769	449	16	5	12286	5	RYR2	1	237944916	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	68434474	237944916	11305705	14	35831										
GEN1	348654	broad.mit.edu	37	chr2	17961316	17961316	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttgaggaagaatcattgtttGaagcagcatatcctgagatc	10	6	1	4			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:17961316G>C	uc002rct.2	+	13	1409	c.1336G>C	c.(1336-1338)GAA>CAA	p.E446Q	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.E446Q|GEN1_uc002rcu.2_Missense_Mutation_p.E446Q	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	446					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ATCATTGTTTGAAGCAGCATA	0.303								Homologous_recombination					0	0	0	0.00361	0	52	6										C	17961316	G	C	17961316	3	2	120	1	0	0	0	0	1	0	0	0	6335	1291	45	1	1382	1	GEN1	2	17961316	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		17961316	225238057	15	35832										
PUM2	23369	broad.mit.edu	37	chr2	20508104	20508104	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggaattgtagtcaaaaaggcCtacagtagctcctgaagagt	11	7	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:20508104C>G	uc002rds.1	-	5	783	c.760G>C	c.(760-762)GGC>CGC	p.G254R	PUM2_uc002rdt.1_Missense_Mutation_p.G254R|PUM2_uc002rdr.2_Missense_Mutation_p.G193R|PUM2_uc010yjy.1_Missense_Mutation_p.G254R|PUM2_uc002rdu.1_Missense_Mutation_p.G254R|PUM2_uc010yjz.1_Missense_Mutation_p.G193R	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	254	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCAAAAAGGCCTACAGTAGCT	0.433													0	0	0	0.00361	0	111	22										G	20508104	C	G	20508104	3	3	120	1	0	0	0	0	1	0	0	0	12826	681	24	4	2498	4	PUM2	2	20508104	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	2546788	20508104	222691269	16	35833										
XPO1	7514	broad.mit.edu	37	chr2	61706062	61706062	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ccgtagggctatttctctctCttccaaaaacaaatcagaag	6	11	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:61706062C>G	uc002sbj.2	-	25	3837	c.3109G>C	c.(3109-3111)GAG>CAG	p.E1037Q	XPO1_uc010fcl.2_Missense_Mutation_p.E1033Q|XPO1_uc010ypn.1_Missense_Mutation_p.E1033Q|XPO1_uc002sbk.2_Missense_Mutation_p.E598Q|XPO1_uc002sbg.2_Missense_Mutation_p.E234Q|XPO1_uc002sbh.2_Missense_Mutation_p.E684Q	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	1037	HEAT 10.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			ATTTCTCTCTCTTCCAAAAAC	0.388													0	0	0	0.00361	0	52	44										G	61706062	C	G	61706062	3	3	120	1	0	0	0	0	1	0	0	0	17442	922	32	1	110	1	XPO1	2	61706062	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	41197958	61706062	181493311	17	35834										
STARD7	56910	broad.mit.edu	37	chr2	96859074	96859074	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ccagggcatcccatttttttCtatactctgtgtccagctgc	7	13	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:96859074C>G	uc002svm.3	-	4	967	c.566G>C	c.(565-567)AGA>ACA	p.R189T	STARD7_uc002svl.2_5'UTR	NM_020151	NP_064536	Q9NQZ5	STAR7_HUMAN	START domain containing 7 precursor	189	START.					mitochondrion					0						CCATTTTTTTCTATACTCTGT	0.443													0	0	0	0.00361	0	43	95										G	96859074	C	G	96859074	3	3	120	1	0	0	0	0	1	0	0	0	15261	913	32	1	566	1	STARD7	2	96859074	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	35153012	96859074	146340299	18	35835										
BUB1	699	broad.mit.edu	37	chr2	111413469	111413469	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tacagttgagtcatccaaaaActcttcagcatgaggcactt	7	10	3	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:111413469A>C	uc002tgc.2	-	16	1835	c.1723T>G	c.(1723-1725)TTT>GTT	p.F575V	BUB1_uc010yxh.1_Missense_Mutation_p.F555V|BUB1_uc010fkb.2_Missense_Mutation_p.F575V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	575					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TCATCCAAAAACTCTTCAGCA	0.438													0	0	0	0.004482	0	7	228										C	111413469	A	C	111413469	3	2	120	1	0	0	0	0	1	0	0	0	1570	43	2	5	1574	5	BUB1	2	111413469	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	14554395	111413469	131785904	19	35836										
MYO7B	4648	broad.mit.edu	37	chr2	128389955	128389955	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gctggcccccgactgcagccGccgaatccagaaggtcctga	12	16	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:128389955G>A	uc002top.2	+	38	5359	c.5306G>A	c.(5305-5307)CGC>CAC	p.R1769H	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1769	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GACTGCAGCCGCCGAATCCAG	0.682													0	0	0	0.006999	0	31	79										A	128389955	G	A	128389955	3	1	120	1	0	0	0	0	1	0	0	0	10083	1087	38	2	5452	2	MYO7B	2	128389955	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	16976486	128389955	114809418	20	35837										
MBD5	55777	broad.mit.edu	37	chr2	149226442	149226442	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	actacaaagagtccagtaatGaaaaaaccaatgtgtaattt	6	6	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:149226442G>C	uc002twm.3	+	9	1918	c.930G>C	c.(928-930)ATG>ATC	p.M310I	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.M310I|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	310						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GTCCAGTAATGAAAAAACCAA	0.448													0	0	0	0.004656	0	23	73										C	149226442	G	C	149226442	3	2	120	1	0	0	0	0	1	0	0	0	9347	1290	45	1	944	1	MBD5	2	149226442	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	20836487	149226442	93972931	21	35838										
TTN	7273	broad.mit.edu	37	chr2	179411950	179411950	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atgattttactgccaccatcGtggtagggttcttcccaacg	9	11	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179411950G>A	uc010zfg.1	-	289	86822	c.86598C>T	c.(86596-86598)CAC>CAT	p.H28866H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.H22561H|TTN_uc010zfi.1_Silent_p.H22494H|TTN_uc010zfj.1_Silent_p.H22369H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29793							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCACCATCGTGGTAGGGTT	0.443													0	0	0	0.004482	0	8	225										A	179411950	G	A	179411950	2	1	120	1	0	0	0	0	0	0	0	1	16732	1136	40	2		2	TTN	2	179411950	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	30185508	179411950	63787423	22	35839										
TTN	7273	broad.mit.edu	37	chr2	179556797	179556797	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aggaactggctttttctcctCtggcacgggtttcttgggaa	12	9	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179556797C>G	uc010zfg.1	-	118	28200	c.27976G>C	c.(27976-27978)GAG>CAG	p.E9326Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E5987Q|TTN_uc010fre.1_Missense_Mutation_p.E437Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10253							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCTCCTCTGGCACGGGT	0.453													0	0	0	0.001855	0	12	35										G	179556797	C	G	179556797	3	3	120	1	0	0	0	0	1	0	0	0	16732	922	32	1	72789	1	TTN	2	179556797	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	144847	179556797	63642576	23	35840										
TTN	7273	broad.mit.edu	37	chr2	179582433	179582433	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atccttgtaccaagacacttGaagaggttctgagccattga	9	9	1	5			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179582433G>A	uc010zfg.1	-	84	21660	c.21436C>T	c.(21436-21438)CAA>TAA	p.Q7146*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.Q3807*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8073							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGACACTTGAAGAGGTTCT	0.398													0	0	0	0.003163	0	14	17										A	179582433	G	A	179582433	4	1	120	1	0	0	0	0	0	1	0	0	16732	1299	45	1	79465	1	TTN	2	179582433	Nonsense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	25636	179582433	63616940	24	35841										
TTN	7273	broad.mit.edu	37	chr2	179590304	179590304	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	taggctgggcgccttctatgGatgcttgtaattcagcaggc	13	9	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179590304G>T	uc010zfg.1	-	68	17119	c.16895C>A	c.(16894-16896)TCC>TAC	p.S5632Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2293Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6559							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCTTCTATGGATGCTTGTAA	0.423													1	0	1.66031e-10	0.003954	1.71497e-10	25	29										T	179590304	G	T	179590304	3	4	120	1	0	0	0	0	1	0	0	0	16732	1174	41	3	84070	3	TTN	2	179590304	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	7871	179590304	63609069	25	35842										
SP100	6672	broad.mit.edu	37	chr2	231281027	231281027	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggaagatggcaggtgggggcGgcgacctgagcaccaggtga	20	8	0	3	rs151275724	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:231281027G>A	uc002vqt.2	+	1	157	c.16G>A	c.(16-18)GGC>AGC	p.G6S	SP100_uc002vqs.2_Missense_Mutation_p.G6S|SP100_uc002vqu.1_Missense_Mutation_p.G6S|SP100_uc010zmb.1_Missense_Mutation_p.G6S|SP100_uc002vqq.1_Missense_Mutation_p.G6S|SP100_uc002vqr.1_Missense_Mutation_p.G6S|SP100_uc010zmc.1_Missense_Mutation_p.G6S|SP100_uc002vqv.1_5'Flank	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	6	Poly-Gly.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGGTGGGGGCGGCGACCTGAG	0.592													0	0	0	0.004482	0	6	23										A	231281027	G	A	231281027	3	1	120	1	0	0	0	0	1	0	0	0	14960	1116	39	2	18	2	SP100	2	231281027	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	51690723	231281027	11918346	26	35843										
FARP2	9855	broad.mit.edu	37	chr2	242433449	242433449	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggaggtgatccagggggccaGcagctcagccgggagggccc	19	12	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:242433449G>A	uc002wbi.1	+	27	3191	c.3074G>A	c.(3073-3075)AGC>AAC	p.S1025N		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	1025	PH 2.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CAGGGGGCCAGCAGCTCAGCC	0.632													0	0	0	0.009535	0	30	65										A	242433449	G	A	242433449	3	1	120	1	0	0	0	0	1	0	0	0	5677	971	34	2	3176	2	FARP2	2	242433449	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	11152422	242433449	765924	27	35844										
CLASP2	23122	broad.mit.edu	37	chr3	33552094	33552094	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggcaaaagcaggtttagggTttccttggacactctctcta	10	9	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:33552094T>A	uc003cfu.2	-	36	4627	c.4273A>T	c.(4273-4275)ACC>TCC	p.T1425S	CLASP2_uc003cfs.2_Missense_Mutation_p.T632S|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1434										ovary(3)|central_nervous_system(1)	4						AGGTTTAGGGTTTCCTTGGAC	0.398													0	0	0	0.001855	0	8	72										A	33552094	T	A	33552094	3	1	120	1	0	0	0	0	1	0	0	0	3455	1725	60	5	259	5	CLASP2	3	33552094	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08		33552094	164470336	28	35845										
WDR48	57599	broad.mit.edu	37	chr3	39093559	39093559	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acacagcagggcggaggaaaGtgcaggtatggaagcccggt	17	8	0	0	rs147741658		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:39093559G>T	uc003cit.2	+	1	53	c.43G>T	c.(43-45)GTG>TTG	p.V15L	WDR48_uc011ayt.1_Missense_Mutation_p.V15L|WDR48_uc011ayu.1_5'UTR|WDR48_uc011ayv.1_Missense_Mutation_p.V15L|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	15					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GCGGAGGAAAGTGCAGGTATG	0.662													1	0	6.50621e-10	0.002836	6.66555e-10	27	60										T	39093559	G	T	39093559	3	4	120	1	0	0	0	0	1	0	0	0	17298	1029	36	4	45	4	WDR48	3	39093559	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	5541465	39093559	158928871	29	35846										
LZTFL1	54585	broad.mit.edu	37	chr3	45879482	45879482	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtctcaagcctctctttgaaCgagcaaaacgcatataatta	6	10	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:45879482C>T	uc003cox.1	-	2	203	c.65G>A	c.(64-66)CGT>CAT	p.R22H	LZTFL1_uc003coy.1_Missense_Mutation_p.R5H|LZTFL1_uc011bak.1_Intron	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	22											0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TCTCTTTGAACGAGCAAAACG	0.393													0	0	0	0.00308	0	6	65										T	45879482	C	T	45879482	3	4	120	1	0	0	0	0	1	0	0	0	9136	536	19	2	870	2	LZTFL1	3	45879482	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	6785923	45879482	152142948	30	35847										
CADPS	8618	broad.mit.edu	37	chr3	62739220	62739220	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cagaatcagctcggaggctgCgctggctgtcatccgggcct	14	13	2	1	rs150415917	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:62739220C>T	uc003dll.2	-	3	1144	c.784G>A	c.(784-786)GCA>ACA	p.A262T	CADPS_uc003dlm.2_Missense_Mutation_p.A262T|CADPS_uc003dln.2_Missense_Mutation_p.A262T	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	262					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCGGAGGCTGCGCTGGCTGTC	0.537													0	0	0	0.00361	0	60	63										T	62739220	C	T	62739220	3	4	120	1	0	0	0	0	1	0	0	0	2570	768	27	2	3462	2	CADPS	3	62739220	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	16859738	62739220	135283210	31	35848										
TMF1	7110	broad.mit.edu	37	chr3	69097297	69097297	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acttacagttggcaccttcaTatccgattctttattaacag	5	10	2	0	rs76863529	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:69097297T>C	uc003dnn.2	-	2	806	c.559A>G	c.(559-561)ATG>GTG	p.M187V	TMF1_uc011bfx.1_Missense_Mutation_p.M187V	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	187					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GGCACCTTCATATCCGATTCT	0.393													0	0	0	0.00361	0	42	144										C	69097297	T	C	69097297	3	2	120	1	0	0	0	0	1	0	0	0	16225	1406	49	5	2786	5	TMF1	3	69097297	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	6358077	69097297	128925133	32	35849										
ARHGAP31	57514	broad.mit.edu	37	chr3	119134219	119134219	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggtcacatggatgacctcatCttactgtaaagcagacccct	8	12	3	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:119134219C>G	uc003ecj.3	+	12	3975	c.3443C>G	c.(3442-3444)TCT>TGT	p.S1148C		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1148					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						ATGACCTCATCTTACTGTAAA	0.532													0	0	0	0.00632	0	27	46										G	119134219	C	G	119134219	3	3	120	1	0	0	0	0	1	0	0	0	880	913	32	1	3489	1	ARHGAP31	3	119134219	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	50036922	119134219	78888211	33	35850										
PIK3R4	30849	broad.mit.edu	37	chr3	130449257	130449257	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tactaattccaggaatctcaGagctgtttctgccagcagag	9	10	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:130449257G>C	uc003enj.2	-	5	2061	c.1480C>G	c.(1480-1482)CTG>GTG	p.L494V		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	494	HEAT 2.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						AGGAATCTCAGAGCTGTTTCT	0.299													0	0	0	0.00623	0	34	51										C	130449257	G	C	130449257	3	2	120	1	0	0	0	0	1	0	0	0	11921	933	33	1	2660	1	PIK3R4	3	130449257	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	11315038	130449257	67573173	34	35851										
TOPBP1	11073	broad.mit.edu	37	chr3	133362908	133362908	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcccacagtggcttccacttCacaccccagcagaggaacca	7	17	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:133362908C>T	uc003eps.2	-	11	1936	c.1804G>A	c.(1804-1806)GAA>AAA	p.E602K		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	602	BRCT 4.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						GCTTCCACTTCACACCCCAGC	0.423								Other_conserved_DNA_damage_response_genes					0	0	0	0.00361	0	54	102										T	133362908	C	T	133362908	3	4	120	1	0	0	0	0	1	0	0	0	16366	835	29	1	2836	1	TOPBP1	3	133362908	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	2913651	133362908	64659522	35	35852										
CHST2	9435	broad.mit.edu	37	chr3	142840195	142840195	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggcgctctggctcgtcgttCttcggcgagctattcaacca	11	13	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:142840195C>T	uc003evm.2	+	2	1426	c.537C>T	c.(535-537)TTC>TTT	p.F179F		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	179	PAPS (Probable).|Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GCTCGTCGTTCTTCGGCGAGC	0.617													0	0	0	0.004656	0	26	29										T	142840195	C	T	142840195	2	4	120	1	0	0	0	0	0	0	0	1	3404	912	32	1		1	CHST2	3	142840195	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	9477287	142840195	55182235	36	35853										
OTOL1	131149	broad.mit.edu	37	chr3	161221324	161221324	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gttggctagagtgccccggtCggctttcagcgctggtttgt	15	10	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:161221324C>A	uc011bpb.1	+	4	1028	c.1028C>A	c.(1027-1029)TCG>TAG	p.S343*		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	343	C1q.					collagen					0						GTGCCCCGGTCGGCTTTCAGC	0.517													1	0	5.35356e-11	0.00278	5.55266e-11	18	31										A	161221324	C	A	161221324	4	1	120	1	0	0	0	0	0	1	0	0	11304	893	31	3	1042	3	OTOL1	3	161221324	Nonsense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	18381129	161221324	36801106	37	35854										
SOX2	6657	broad.mit.edu	37	chr3	181430953	181430953	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggcgccctgccaggccgggGacctccgggacatgatcagc	16	15	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:181430953G>T	uc003fkx.2	+	1	1232	c.805G>T	c.(805-807)GAC>TAC	p.D269Y	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	269					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			CCAGGCCGGGGACCTCCGGGA	0.682			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						1	0	1.95512e-22	0.00361	2.09716e-22	47	84										T	181430953	G	T	181430953	3	4	120	1	0	0	0	0	1	0	0	0	14949	1174	41	3	807	3	SOX2	3	181430953	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	20209629	181430953	16591477	38	35855										
MFSD10	10227	broad.mit.edu	37	chr4	2932969	2932969	+	Frame_Shift_Del	DEL	C	C	-													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctcaccatagccagcgaccaCggaggacaggcagggcacca							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:2932969delC	uc003gfw.2	-	10	1461	c.1147delG	c.(1147-1149)GTGfs	p.V383fs	MFSD10_uc003gfv.2_Frame_Shift_Del_p.V73fs|MFSD10_uc003gfx.2_Frame_Shift_Del_p.V207fs|MFSD10_uc003gfz.2_Frame_Shift_Del_p.V383fs|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Frame_Shift_Del_p.P346fs|MFSD10_uc003ggb.1_Frame_Shift_Del_p.V383fs|MFSD10_uc003ggc.2_Intron	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	383					apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCAGCGACCACGGAGGACAGG	0.692																		2	4	---	---								-	2932969	C	-	2932969	7	5	120	1	0	1	0	1	0	0	0	0	9528	536	19	0	232	0	MFSD10	4	2932969	Frame_Shift_Del	DEL	C	TCGA-GV-A3QH-01A-11D-A21Z-08		2932969	188221307	39	35856										
TBC1D19	55296	broad.mit.edu	37	chr4	26675453	26675453	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tacatcagacaaggaagtccCacggcactgagagctgaatt	10	10	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:26675453C>T	uc003gsf.3	+	11	1029	c.759C>T	c.(757-759)CCC>CCT	p.P253P	TBC1D19_uc010iew.2_Silent_p.P253P|TBC1D19_uc011bxu.1_Silent_p.P188P	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	253	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				AAGGAAGTCCCACGGCACTGA	0.408													0	0	0	0.001984	0	5	43										T	26675453	C	T	26675453	2	4	120	1	0	0	0	0	0	0	0	1	15604	581	21	2		2	TBC1D19	4	26675453	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	23742484	26675453	164478823	40	35857										
PDGFRA	5156	broad.mit.edu	37	chr4	55139760	55139760	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	caatgtctcaaacatcatcaCggagatccactcccgagaca	6	14	3	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:55139760C>T	uc003han.3	+	10	1752	c.1421C>T	c.(1420-1422)ACG>ATG	p.T474M	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.T368M|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	474	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AACATCATCACGGAGATCCAC	0.493			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.00361	0	47	58										T	55139760	C	T	55139760	3	4	120	1	0	0	0	0	1	0	0	0	11661	536	19	2	1455	2	PDGFRA	4	55139760	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	28464307	55139760	136014516	41	35858										
C4orf14	84273	broad.mit.edu	37	chr4	57840060	57840060	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctttttgaggacattaagctGattttgttcttgctcactaa	7	7	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:57840060G>C	uc003hck.2	-	2	1348	c.1273C>G	c.(1273-1275)CAG>GAG	p.Q425E		NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	425							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					ACATTAAGCTGATTTTGTTCT	0.368													0	0	0	0.003271	0	30	121										C	57840060	G	C	57840060	3	2	120	1	0	0	0	0	1	0	0	0	2251	1299	45	1	847	1	C4orf14	4	57840060	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	2700300	57840060	133314216	42	35859										
SCARB2	950	broad.mit.edu	37	chr4	77102129	77102129	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atacaggaatatttaatgttCtaattaagtcaattttaggg	7	3	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:77102129C>G	uc003hju.1	-	3	740	c.401G>C	c.(400-402)AGA>ACA	p.R134T	SCARB2_uc011cbu.1_Intron	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	134	Lumenal (Potential).				cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			ATTTAATGTTCTAATTAAGTC	0.318													0	0	0	0.011902	0	38	18										G	77102129	C	G	77102129	3	3	120	1	0	0	0	0	1	0	0	0	13882	913	32	1	1075	1	SCARB2	4	77102129	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	19262069	77102129	114052147	43	35860										
DKK2	27123	broad.mit.edu	37	chr4	107956668	107956668	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttggcccgcgaactgccgatCtgtgagctctccaccatcag	10	15	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:107956668C>G	uc003hyi.2	-	1	786	c.81G>C	c.(79-81)CAG>CAC	p.Q27H	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.Q27H	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	27					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		AACTGCCGATCTGTGAGCTCT	0.647													0	0	0	0.009096	0	4	166										G	107956668	C	G	107956668	3	3	120	1	0	0	0	0	1	0	0	0	4545	912	32	1	714	1	DKK2	4	107956668	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	30854539	107956668	83197608	44	35861										
HHIP	64399	broad.mit.edu	37	chr4	145567851	145567853	+	In_Frame_Del	DEL	GCT	GCT	-													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctgaagatgctctcctttaaGctgctgctgctggccgtggc							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:145567851_145567853delGCT	uc003ijs.1	+	1	679_681	c.24_26delGCT	c.(22-27)AAGCTG>AAG	p.L12del	uc003ijq.1_5'Flank|HHIP_uc003ijr.1_In_Frame_Del_p.L12del	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	12						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TCTCCTTTAAGCTGCTGCTGCTG	0.621											OREG0016346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						7	536	---	---								-	145567853	GCT	-	145567851	7	5	120	1	0	1	0	1	0	0	0	0	7092	962	34	0	26	0	HHIP	4	145567851	In_Frame_Del	DEL	GCT	TCGA-GV-A3QH-01A-11D-A21Z-08	37611183	145567851	45586425	45	35862										
SMAD1	4086	broad.mit.edu	37	chr4	146463782	146463782	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcctgaagaccccatgacccAggatggctctcagccgatgg	11	14	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:146463782A>G	uc003ikc.2	+	4	1123	c.707A>G	c.(706-708)CAG>CGG	p.Q236R	SMAD1_uc003ikd.2_Missense_Mutation_p.Q236R|SMAD1_uc010iov.2_Missense_Mutation_p.Q236R|SMAD1_uc011cic.1_Intron	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1	236					BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					CCCATGACCCAGGATGGCTCT	0.468													0	0	0	0.010504	0	19	384										G	146463782	A	G	146463782	3	3	120	1	0	0	0	0	1	0	0	0	14757	188	7	5	717	5	SMAD1	4	146463782	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	895931	146463782	44690494	46	35863										
TLL1	7092	broad.mit.edu	37	chr4	166935664	166935664	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	caattggtcagcgaacccgtCtaagcaaaggagatatcgca	10	10	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:166935664C>G	uc003irh.1	+	8	1641	c.994C>G	c.(994-996)CTA>GTA	p.L332V	TLL1_uc011cjn.1_Missense_Mutation_p.L332V|TLL1_uc011cjo.1_Missense_Mutation_p.L156V	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	332	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GCGAACCCGTCTAAGCAAAGG	0.463													0	0	0	0.000602	0	4	184										G	166935664	C	G	166935664	3	3	120	1	0	0	0	0	1	0	0	0	15942	912	32	1	1024	1	TLL1	4	166935664	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	20471882	166935664	24218612	47	35864										
TLR3	7098	broad.mit.edu	37	chr4	187004826	187004826	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggtttgttaattggattaaCgagacccataccaacatccc	7	10	0	1	rs149490656		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:187004826C>T	uc003iyq.2	+	4	2087	c.1986C>T	c.(1984-1986)AAC>AAT	p.N662N	TLR3_uc011ckz.1_Silent_p.N385N|TLR3_uc003iyr.2_Silent_p.N385N	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	662	Lumenal (Potential).|LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ATTGGATTAACGAGACCCATA	0.443													0	0	0	0.00361	0	89	65										T	187004826	C	T	187004826	2	4	120	1	0	0	0	0	0	0	0	1	15949	535	19	2		2	TLR3	4	187004826	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	20069162	187004826	4149450	48	35865										
KIAA0947	23379	broad.mit.edu	37	chr5	5476116	5476116	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggcctgtgatggataaatgGataaaatacagaaaaggaca	11	4	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:5476116G>C	uc003jdm.3	+	17	6666	c.6444G>C	c.(6442-6444)TGG>TGC	p.W2148C		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2148										ovary(1)|central_nervous_system(1)	2						TGGATAAATGGATAAAATACA	0.313													0	0	0	0.009096	0	3	38										C	5476116	G	C	5476116	3	2	120	1	0	0	0	0	1	0	0	0	8202	1183	41	1	6510	1	KIAA0947	5	5476116	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		5476116	175439144	49	35866										
ADCY2	108	broad.mit.edu	37	chr5	7773125	7773125	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tatgagctgaagatgttgatCatgatggtggccttggtggg	16	4	1	5			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:7773125C>T	uc003jdz.1	+	18	2362	c.2295C>T	c.(2293-2295)ATC>ATT	p.I765I	ADCY2_uc011cmo.1_Silent_p.I585I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	765	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGATGTTGATCATGATGGTGG	0.527													0	0	0	0.00361	0	47	199										T	7773125	C	T	7773125	2	4	120	1	0	0	0	0	0	0	0	1	294	816	29	1		1	ADCY2	5	7773125	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	2297009	7773125	173142135	50	35867										
ITGA2	3673	broad.mit.edu	37	chr5	52351969	52351969	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acattaggagaacaaattttCagcattgaaggtaaaaaaaa	7	4	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:52351969C>T	uc003joy.2	+	9	1229	c.1086C>T	c.(1084-1086)TTC>TTT	p.F362F	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.F286F|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	362	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AACAAATTTTCAGCATTGAAG	0.299													0	0	0	0.010504	0	19	54										T	52351969	C	T	52351969	2	4	120	1	0	0	0	0	0	0	0	1	7875	825	29	1		1	ITGA2	5	52351969	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	44578844	52351969	128563291	51	35868										
RAB3C	115827	broad.mit.edu	37	chr5	58021940	58021940	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aagaatccttcaatgcagtaCaagattggtaagtcagagca	9	7	2	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:58021940C>T	uc003jrp.2	+	3	461	c.364C>T	c.(364-366)CAA>TAA	p.Q122*		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	122					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		CAATGCAGTACAAGATTGGTA	0.398													0	0	0	0.005443	0	26	48										T	58021940	C	T	58021940	4	4	120	1	0	0	0	0	0	1	0	0	12933	479	17	2	374	2	RAB3C	5	58021940	Nonsense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	5669971	58021940	122893320	52	35869										
CDK7	1022	broad.mit.edu	37	chr5	68531243	68531243	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgccaccgtttacaaggccaGagataagaacaccaaccaaa	7	12	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:68531243G>C	uc003jvs.3	+	2	270	c.89G>C	c.(88-90)AGA>ACA	p.R30T	CDK7_uc010ixd.1_Missense_Mutation_p.R30T|CDK7_uc003jvt.3_5'UTR|CDK7_uc003jvu.3_5'UTR	NM_001799	NP_001790	P50613	CDK7_HUMAN	cyclin-dependent kinase 7	30	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			lung(1)	1		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		TACAAGGCCAGAGATAAGAAC	0.333								NER					0	0	0	0.007413	0	16	42										C	68531243	G	C	68531243	3	2	120	1	0	0	0	0	1	0	0	0	3149	942	33	1	95	1	CDK7	5	68531243	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	10509303	68531243	112384017	53	35870										
CCDC125	202243	broad.mit.edu	37	chr5	68616096	68616096	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtcgtctgtaattggaaattCtggacacttgagggaatgta	12	5	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:68616096C>G	uc003jvv.1	-	1	315	c.272G>C	c.(271-273)AGA>ACA	p.R91T	CCDC125_uc003jvx.1_Missense_Mutation_p.R91T|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_5'UTR|CCDC125_uc003jvz.1_Missense_Mutation_p.R91T	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	91						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		ATTGGAAATTCTGGACACTTG	0.418													0	0	0	0.00361	0	71	139										G	68616096	C	G	68616096	3	3	120	1	0	0	0	0	1	0	0	0	2761	913	32	1	1307	1	CCDC125	5	68616096	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	84853	68616096	112299164	54	35871										
RIOK2	55781	broad.mit.edu	37	chr5	96500768	96500768	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tacttactggaggaattgttGaacagcttacagcactgcct	9	9	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:96500768G>A	uc003kmz.2	-	9	1591	c.1481C>T	c.(1480-1482)TCA>TTA	p.S494L		NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	494	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		AGGAATTGTTGAACAGCTTAC	0.358													0	0	0	0.010818	0	27	58										A	96500768	G	A	96500768	3	1	120	1	0	0	0	0	1	0	0	0	13378	1294	45	1	185	1	RIOK2	5	96500768	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	27884672	96500768	84414492	55	35872										
CSNK1G3	1456	broad.mit.edu	37	chr5	122881389	122881389	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaagaaagacaaggacaaatCagatgatagaatggcacgac	10	6	1	5			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:122881389C>G	uc003ktm.2	+	2	751	c.32C>G	c.(31-33)TCA>TGA	p.S11*	CSNK1G3_uc003ktl.2_Nonsense_Mutation_p.S11*|CSNK1G3_uc003ktn.2_Nonsense_Mutation_p.S11*|CSNK1G3_uc003kto.2_Nonsense_Mutation_p.S11*|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Nonsense_Mutation_p.S11*	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	11					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		AAGGACAAATCAGATGATAGA	0.408													0	0	0	0.001368	0	11	33										G	122881389	C	G	122881389	4	3	120	1	0	0	0	0	0	1	0	0	3956	838	29	1	34	1	CSNK1G3	5	122881389	Nonsense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	26380621	122881389	58033871	56	35873										
CHSY3	337876	broad.mit.edu	37	chr5	129520128	129520128	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cacagggaaagtgccctgatGagcaagctcagtaacacaga	11	10	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:129520128G>A	uc003kvd.2	+	3	1293	c.1293G>A	c.(1291-1293)ATG>ATA	p.M431I		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	431	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GTGCCCTGATGAGCAAGCTCA	0.502													0	0	0	0.010729	0	9	86										A	129520128	G	A	129520128	3	1	120	1	0	0	0	0	1	0	0	0	3413	1290	45	1	1303	1	CHSY3	5	129520128	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	6638739	129520128	51395132	57	35874										
KLHL3	26249	broad.mit.edu	37	chr5	136969816	136969816	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cacagtgctcagacactggcGggaagctccatcataacccc	9	15	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:136969816G>A	uc010jek.2	-	12	1804	c.1360C>T	c.(1360-1362)CGC>TGC	p.R454C	KLHL3_uc011cyc.1_Missense_Mutation_p.R189C|KLHL3_uc003lbr.3_Missense_Mutation_p.R372C|KLHL3_uc011cyd.1_Intron|KLHL3_uc010jel.1_Missense_Mutation_p.R189C	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	454	Kelch 4.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		AGACACTGGCGGGAAGCTCCA	0.557													0	0	0	0.004672	0	3	92										A	136969816	G	A	136969816	3	1	120	1	0	0	0	0	1	0	0	0	8383	1116	39	2	419	2	KLHL3	5	136969816	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	7449688	136969816	43945444	58	35875										
WNT8A	7478	broad.mit.edu	37	chr5	137426224	137426224	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctctctatgaaggcagtgaGagccaccatgaaaaggacat	10	9	2	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:137426224G>A	uc003lcd.1	+	6	523	c.518G>A	c.(517-519)AGA>AAA	p.R173K	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Missense_Mutation_p.R191K|WNT8A_uc011cyk.1_Missense_Mutation_p.R191K	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	173					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AAGGCAGTGAGAGCCACCATG	0.453													0	0	0	0.004656	0	21	30										A	137426224	G	A	137426224	3	1	120	1	0	0	0	0	1	0	0	0	17393	942	33	1	540	1	WNT8A	5	137426224	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	456408	137426224	43489036	59	35876										
PCDHA10	56139	broad.mit.edu	37	chr5	140237156	140237156	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctcgctgtcgagctacgtgtCggtgcacgcggagagcggca	16	12	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140237156C>T	uc003lhx.2	+	1	1523	c.1523C>T	c.(1522-1524)TCG>TTG	p.S508L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.S508L|PCDHA10_uc011dad.1_Missense_Mutation_p.S508L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	508	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTACGTGTCGGTGCACGCG	0.692													0	0	0	0.00361	0	44	116										T	140237156	C	T	140237156	3	4	120	1	0	0	0	0	1	0	0	0	11520	893	31	1	1525	1	PCDHA10	5	140237156	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	2810932	140237156	40678104	60	35877										
PCDHB9	56127	broad.mit.edu	37	chr5	140569145	140569145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgttccagagctaccagtacGaggtgtgtctgactggaggt	14	8	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140569145G>A	uc003liw.1	+	3	2254	c.2254G>A	c.(2254-2256)GAG>AAG	p.E752K	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	752	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTACCAGTACGAGGTGTGTCT	0.622													0	0	0	0.00361	0	71	170										A	140569145	G	A	140569145	3	1	120	1	0	0	0	0	1	0	0	0	11549	1045	37	1	2255	1	PCDHB9	5	140569145	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	331989	140569145	40346115	61	35878										
PCDHB9	56127	broad.mit.edu	37	chr5	140569220	140569220	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttaccccccacctcccgcccCataggggtgggaaagaaata	9	15	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140569220C>T	uc003liw.1	+	3	2329	c.2329C>T	c.(2329-2331)CAT>TAT	p.H777Y	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	777	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCCGCCCCATAGGGGTGG	0.463													0	0	0	0.00361	0	45	96										T	140569220	C	T	140569220	3	4	120	1	0	0	0	0	1	0	0	0	11549	581	21	2	2330	2	PCDHB9	5	140569220	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	75	140569220	40346040	62	35879										
PCDHGA10	56106	broad.mit.edu	37	chr5	140793096	140793096	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atccttgtggaagacagggtGaaactttttgggatagaaat	12	4	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140793096G>A	uc003lkl.1	+	1	354	c.354G>A	c.(352-354)GTG>GTA	p.V118V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.V118V	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	118	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGACAGGGTGAAACTTTTTG	0.463													0	0	0	0.010504	0	19	32										A	140793096	G	A	140793096	2	1	120	1	0	0	0	0	0	0	0	1	11551	1277	45	1		1	PCDHGA10	5	140793096	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	223876	140793096	40122164	63	35880										
GPR151	134391	broad.mit.edu	37	chr5	145894805	145894805	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggaaaacatcaagacttgaGacagggctatgaaaccttgt	10	7	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:145894805G>C	uc003lod.1	-	1	872	c.872C>G	c.(871-873)TCT>TGT	p.S291C		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	291	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAGACTTGAGACAGGGCTAT	0.502													0	0	0	0.007413	0	17	38										C	145894805	G	C	145894805	3	2	120	1	0	0	0	0	1	0	0	0	6657	942	33	1	391	1	GPR151	5	145894805	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	5101709	145894805	35020455	64	35881										
ZFP2	80108	broad.mit.edu	37	chr5	178359437	178359437	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cccttaccgtgcatcaggtcAttcacactggagagaaacct	8	13	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:178359437A>T	uc003mjn.1	+	5	1632	c.1123A>T	c.(1123-1125)ATT>TTT	p.I375F	ZFP2_uc010jky.2_Missense_Mutation_p.I375F|ZFP2_uc010jkx.1_Missense_Mutation_p.I375F	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	375	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GCATCAGGTCATTCACACTGG	0.423													0	0	0	0.010729	0	9	82										T	178359437	A	T	178359437	3	4	120	1	0	0	0	0	1	0	0	0	17638	217	8	5	1125	5	ZFP2	5	178359437	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	32464632	178359437	2555823	65	35882										
MAML1	9794	broad.mit.edu	37	chr5	179201773	179201773	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggcagccaggtggcagtggGctctctagtgtggctggaca	18	9	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:179201773G>T	uc003mkm.2	+	5	3209	c.2946G>T	c.(2944-2946)GGG>GGT	p.G982G	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	982					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGGCAGTGGGCTCTCTAGTG	0.627													1	0	1.37657e-19	0.012319	1.46406e-19	22	52										T	179201773	G	T	179201773	2	4	120	1	0	0	0	0	0	0	0	1	9205	1190	42	4		4	MAML1	5	179201773	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	842336	179201773	1713487	66	35883										
BTN2A2	10385	broad.mit.edu	37	chr6	26393028	26393028	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgagggacagatcgcacatcTacacatgtccccgttcagcc	9	14	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:26393028T>C	uc003nhq.2	+	8	1491	c.1405T>C	c.(1405-1407)TAC>CAC	p.Y469H	BTN2A2_uc011dkg.1_3'UTR|BTN2A2_uc003nhr.2_Missense_Mutation_p.Y353H|BTN2A2_uc011dkh.1_Missense_Mutation_p.Y259H|BTN2A2_uc003nhs.2_Intron|BTN2A2_uc003nht.2_Missense_Mutation_p.Y469H|BTN2A2_uc011dki.1_3'UTR	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	469	B30.2/SPRY.|Cytoplasmic (Potential).				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						ATCGCACATCTACACATGTCC	0.542													0	0	0	0.001368	0	10	80										C	26393028	T	C	26393028	3	2	120	1	0	0	0	0	1	0	0	0	1561	1522	53	5	1431	5	BTN2A2	6	26393028	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08		26393028	144722039	67	35884										
CUL7	9820	broad.mit.edu	37	chr6	43011253	43011253	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acatgcaccagcaggtgagtGagacggcgcacccgcgagaa	14	12	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:43011253G>A	uc003otq.2	-	17	3591	c.3288C>T	c.(3286-3288)CTC>CTT	p.L1096L	CUL7_uc010jyg.2_Silent_p.L375L|CUL7_uc011dvb.1_Silent_p.L1180L|CUL7_uc010jyh.2_Silent_p.L89L|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1096					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCAGGTGAGTGAGACGGCGCA	0.647													0	0	0	0.00361	0	79	12										A	43011253	G	A	43011253	2	1	120	1	0	0	0	0	0	0	0	1	4060	1277	45	1		1	CUL7	6	43011253	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	16618225	43011253	128103814	68	35885										
RIMS1	22999	broad.mit.edu	37	chr6	73110200	73110200	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atttctctatctctgcaggtGattgtctggggagactatgg	12	7	3	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:73110200G>C	uc003pga.2	+	34	4940	c.4863G>C	c.(4861-4863)GTG>GTC	p.V1621V	RIMS1_uc011dyb.1_Silent_p.V1018V|RIMS1_uc003pgc.2_Silent_p.V1036V|RIMS1_uc010kaq.2_Silent_p.V941V|RIMS1_uc011dyc.1_Silent_p.V746V|RIMS1_uc010kar.2_Silent_p.V689V|RIMS1_uc011dyd.1_Silent_p.V755V|RIMS1_uc003pgf.2_Silent_p.V621V|RIMS1_uc003pgg.2_Silent_p.V517V|RIMS1_uc003pgi.2_Silent_p.V437V|RIMS1_uc003pgh.2_Silent_p.V488V|RIMS1_uc003pgd.2_Silent_p.V687V|RIMS1_uc003pge.2_Silent_p.V661V|RIMS1_uc011dye.1_Silent_p.V427V|RIMS1_uc011dyf.1_Silent_p.V245V|RIMS1_uc011dyg.1_Silent_p.V148V	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1621	C2 2.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTCTGCAGGTGATTGTCTGGG	0.478													0	0	0	0.010729	0	11	43										C	73110200	G	C	73110200	2	2	120	1	0	0	0	0	0	0	0	1	13367	1277	45	1		1	RIMS1	6	73110200	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	30098947	73110200	98004867	69	35886										
DOPEY1	23033	broad.mit.edu	37	chr6	83818645	83818645	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atagttctggattatttcctCttcttgcaaatgctgccatg	7	9	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:83818645C>G	uc003pjs.1	+	5	597	c.337C>G	c.(337-339)CTT>GTT	p.L113V	DOPEY1_uc011dyy.1_Missense_Mutation_p.L113V|DOPEY1_uc010kbl.1_Missense_Mutation_p.L113V	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	113					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ATTATTTCCTCTTCTTGCAAA	0.313													0	0	0	0.007291	0	24	56										G	83818645	C	G	83818645	3	3	120	1	0	0	0	0	1	0	0	0	4707	913	32	1	347	1	DOPEY1	6	83818645	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	10708445	83818645	87296422	70	35887										
KLHL32	114792	broad.mit.edu	37	chr6	97561859	97561859	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agcatctatgcacagcctgtCtggcagactcgcaggaccaa	10	13	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:97561859C>T	uc010kcm.1	+	7	1300	c.828C>T	c.(826-828)GTC>GTT	p.V276V	KLHL32_uc003poy.2_Silent_p.V276V|KLHL32_uc011ead.1_Silent_p.V240V|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Silent_p.V207V|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	276										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CACAGCCTGTCTGGCAGACTC	0.542													0	0	0	0.004878	0	31	43										T	97561859	C	T	97561859	2	4	120	1	0	0	0	0	0	0	0	1	8386	900	32	1		1	KLHL32	6	97561859	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	13743214	97561859	73553208	71	35888										
FIG4	9896	broad.mit.edu	37	chr6	110110816	110110816	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtgactttatgcctaagaccGttggaattgatccaagtcca	9	9	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:110110816G>A	uc003ptt.2	+	19	2331	c.2116G>A	c.(2116-2118)GTT>ATT	p.V706I	FIG4_uc011eau.1_Missense_Mutation_p.V429I	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	706					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GCCTAAGACCGTTGGAATTGA	0.358													0	0	0	0.007291	0	22	63										A	110110816	G	A	110110816	3	1	120	1	0	0	0	0	1	0	0	0	5888	1145	40	2	2190	2	FIG4	6	110110816	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	12548957	110110816	61004251	72	35889										
SYNE1	23345	broad.mit.edu	37	chr6	152772267	152772267	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cagttctgcattcttctacaGaggctaagaacctattcttc	6	11	4	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:152772267G>A	uc010kiw.2	-	26	3703	c.3101C>T	c.(3100-3102)TCT>TTT	p.S1034F	SYNE1_uc003qot.3_Missense_Mutation_p.S1041F|SYNE1_uc003qou.3_Missense_Mutation_p.S1034F|SYNE1_uc010kjb.1_Missense_Mutation_p.S1017F|SYNE1_uc003qow.2_Missense_Mutation_p.S329F|SYNE1_uc003qox.1_Missense_Mutation_p.S550F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1034	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTTCTACAGAGGCTAAGAA	0.443										HNSCC(10;0.0054)			0	0	0	0.00623	0	37	70										A	152772267	G	A	152772267	3	1	120	1	0	0	0	0	1	0	0	0	15442	942	33	1	23849	1	SYNE1	6	152772267	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	42661451	152772267	18342800	73	35890										
EZR	7430	broad.mit.edu	37	chr6	159192335	159192335	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gccttcatctgctgcacctcGatggtgtcaggcttcctgcg	11	14	3	0	rs139648265	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:159192335G>C	uc003qrt.3	-	8	1115	c.900C>G	c.(898-900)ATC>ATG	p.I300M	EZR_uc011efr.1_5'Flank|EZR_uc011efs.1_Missense_Mutation_p.I268M|EZR_uc003qru.3_Missense_Mutation_p.I300M	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	300	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GCTGCACCTCGATGGTGTCAG	0.597													0	0	0	0.007413	0	17	46										C	159192335	G	C	159192335	3	2	120	1	0	0	0	0	1	0	0	0	5335	1048	37	1	884	1	EZR	6	159192335	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	6420068	159192335	11922732	74	35891										
PNLDC1	154197	broad.mit.edu	37	chr6	160239602	160239602	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgcagcatcgaccccgtgccCgagtcatcctttcctcagta	8	16	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:160239602C>T	uc003qsx.1	+	16	1311	c.1140C>T	c.(1138-1140)CCC>CCT	p.P380P	PNLDC1_uc003qsy.1_Silent_p.P391P	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	380	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ACCCCGTGCCCGAGTCATCCT	0.552													0	0	0	0.012319	0	18	37										T	160239602	C	T	160239602	2	4	120	1	0	0	0	0	0	0	0	1	12148	639	23	2		2	PNLDC1	6	160239602	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	1047267	160239602	10875465	75	35892										
DLL1	28514	broad.mit.edu	37	chr6	170597419	170597419	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cgaaggcatcgtcccggggaCggcagaaaacggagcagccc	15	13	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:170597419C>T	uc003qxm.2	-	4	1048	c.578G>A	c.(577-579)CGT>CAT	p.R193H	DLL1_uc011ehc.1_Missense_Mutation_p.R193H	NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	193	Extracellular (Potential).|DSL.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		GTCCCGGGGACGGCAGAAAAC	0.622													0	0	0	0.012213	0	24	49										T	170597419	C	T	170597419	3	4	120	1	0	0	0	0	1	0	0	0	4566	536	19	2	1625	2	DLL1	6	170597419	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	10357817	170597419	517648	76	35893										
MICALL2	79778	broad.mit.edu	37	chr7	1487240	1487240	+	Missense_Mutation	SNP	C	C	T													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggcgggccccctgcaccctCattcctcctctggaccacag							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:1487240C>T	uc003skj.3	-	4	643	c.496G>A	c.(496-498)GAG>AAG	p.E166K		NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	166						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CCTGCACCCTCATTCCTCCTC	0.677													0	0	0	0.006214	0	6	16										T	1487240	C	T	1487240	3	4	120	1	0	0	0	0	1	0	0	0	9574	835	29	1	2274	1	MICALL2	7	1487240	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		1487240	157651423	77	35894	188	2								
MICALL2	79778	broad.mit.edu	37	chr7	1487250	1487250	+	Missense_Mutation	SNP	C	C	G													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cctgcaccctcattcctcctCtggaccacagggtttgtctg							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:1487250C>G	uc003skj.3	-	4	633	c.486G>C	c.(484-486)CAG>CAC	p.Q162H		NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	162						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CATTCCTCCTCTGGACCACAG	0.672													0	0	0	0.006214	0	6	15										G	1487250	C	G	1487250	3	3	120	1	0	0	0	0	1	0	0	0	9574	912	32	1	2284	1	MICALL2	7	1487250	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	10	1487250	157651413	78	35895	188	2								
DFNA5	1687	broad.mit.edu	37	chr7	24745981	24745981	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	actgtgggcgagaggccgctGaccaggtcatcgcactgtag	15	11	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:24745981G>T	uc010kus.1	-	8	1093	c.1005C>A	c.(1003-1005)GTC>GTA	p.V335V	DFNA5_uc003swz.2_Silent_p.V171V|DFNA5_uc003sxa.1_Silent_p.V335V|DFNA5_uc010kut.1_Silent_p.V171V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	335					sensory perception of sound					ovary(1)	1						AGAGGCCGCTGACCAGGTCAT	0.647													1	0	6.32553e-13	0.004656	6.588e-13	21	14										T	24745981	G	T	24745981	2	4	120	1	0	0	0	0	0	0	0	1	4454	1277	45	3		3	DFNA5	7	24745981	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	23258731	24745981	134392682	79	35896										
NFE2L3	9603	broad.mit.edu	37	chr7	26224981	26224981	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctttttctgtagatgaaattGtcggcatgcctgttgattct	9	7	2	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:26224981G>A	uc003sxq.2	+	4	1935	c.1663G>A	c.(1663-1665)GTC>ATC	p.V555I		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	555					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						AGATGAAATTGTCGGCATGCC	0.398													0	0	0	0.001855	0	11	81										A	26224981	G	A	26224981	3	1	120	1	0	0	0	0	1	0	0	0	10369	1377	48	2	1677	2	NFE2L3	7	26224981	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1479000	26224981	132913682	80	35897										
LOC402644	402644	broad.mit.edu	37	chr7	28319234	28319234	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gttttctgctgtctttggaaActtttctgcaaacagctcaa	7	9	4	0	rs177484	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:28319234A>C	uc010kuz.1	-	1	85	c.85T>G	c.(85-87)TTT>GTT	p.F29V		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						GTCTTTGGAAACTTTTCTGCA	0.468													0	0	0	0.009096	0	3	62										C	28319234	A	C	28319234	3	2	120	1	0	0	0	0	1	0	0	0	8878	43	2	5	395	5	LOC402644	7	28319234	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	2094253	28319234	130819429	81	35898										
AMPH	273	broad.mit.edu	37	chr7	38543250	38543250	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaacaactcatacacattacCtttgattgctgctaaatatc	3	10	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:38543250C>T	uc003tgu.2	-	3	274	c.205G>A	c.(205-207)GGC>AGC	p.G69S	AMPH_uc003tgv.2_Missense_Mutation_p.G69S	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	69	BAR.|Potential.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TACACATTACCTTTGATTGCT	0.393													0	0	0	0.00361	0	129	87										T	38543250	C	T	38543250	3	4	120	1	0	0	0	0	1	0	0	0	588	695	24	2	1958	2	AMPH	7	38543250	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	10224016	38543250	120595413	82	35899										
IKZF1	10320	broad.mit.edu	37	chr7	50468280	50468280	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agccaggaccggtacgagttCtcgtcgcacataacgcgagg	13	12	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:50468280C>T	uc003tow.3	+	9	1683	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F	IKZF1_uc003tox.3_Silent_p.F463F|IKZF1_uc003toy.3_Silent_p.F463F|IKZF1_uc011kck.1_Silent_p.F418F|IKZF1_uc003toz.3_Silent_p.F475F|IKZF1_uc010kyx.2_Silent_p.F245F|IKZF1_uc003tpa.3_Silent_p.F247F	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	505	C2H2-type 6.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GGTACGAGTTCTCGTCGCACA	0.607			D		ALL								0	0	0	0.009535	0	24	46										T	50468280	C	T	50468280	2	4	120	1	0	0	0	0	0	0	0	1	7614	912	32	1		1	IKZF1	7	50468280	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	11925030	50468280	108670383	83	35900										
GRB10	2887	broad.mit.edu	37	chr7	50660679	50660679	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	actcggatgcagtggtgcttGagtttgcaaggcaggactcc	14	9	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:50660679G>C	uc003tpi.2	-	16	1786	c.1755C>G	c.(1753-1755)CTC>CTG	p.L585L	GRB10_uc003tph.3_Silent_p.L527L|GRB10_uc003tpj.2_Silent_p.L539L|GRB10_uc003tpk.2_Silent_p.L585L|GRB10_uc010kzb.2_Silent_p.L527L|GRB10_uc003tpl.2_Silent_p.L579L|GRB10_uc003tpm.2_Silent_p.L527L|GRB10_uc003tpn.2_Silent_p.L527L	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	585					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					AGTGGTGCTTGAGTTTGCAAG	0.522									Russell-Silver_syndrome				0	0	0	0.00361	0	88	106										C	50660679	G	C	50660679	2	2	120	1	0	0	0	0	0	0	0	1	6756	1277	45	1		1	GRB10	7	50660679	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	192399	50660679	108477984	84	35901										
AUTS2	26053	broad.mit.edu	37	chr7	70255920	70255920	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctcccagaaggacgactcctCtgtccgcagagataagggag	12	12	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:70255920C>T	uc003tvw.3	+	19	4461	c.3718C>T	c.(3718-3720)CTG>TTG	p.L1240L	AUTS2_uc003tvx.3_Silent_p.L1216L|AUTS2_uc011keg.1_Silent_p.L692L	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1240										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GACGACTCCTCTGTCCGCAGA	0.622													0	0	0	0.001855	0	13	15										T	70255920	C	T	70255920	2	4	120	1	0	0	0	0	0	0	0	1	1225	912	32	1		1	AUTS2	7	70255920	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	19595241	70255920	88882743	85	35902										
TYW1B	441250	broad.mit.edu	37	chr7	72193853	72193853	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cttcaagatcatttcaggctGgtccatcttctaccgccatt	6	13	5	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:72193853G>A	uc011kej.1	-	12	1288	c.1129C>T	c.(1129-1131)CAG>TAG	p.Q377*	TYW1B_uc011keh.1_Nonsense_Mutation_p.Q215*|TYW1B_uc011kei.1_Nonsense_Mutation_p.Q3*|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	377					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						ATTTCAGGCTGGTCCATCTTC	0.423													0	0	0	0.006122	0	13	9										A	72193853	G	A	72193853	4	1	120	1	0	0	0	0	0	1	0	0	16816	1357	47	2	1022	2	TYW1B	7	72193853	Nonsense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1937933	72193853	86944810	86	35903										
ST7	7982	broad.mit.edu	37	chr7	116859168	116859168	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gatcccttatcccttggaaaAggggcacctattttatcctt	7	11	0	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:116859168A>G	uc003vin.2	+	14	1650	c.1436A>G	c.(1435-1437)AAG>AGG	p.K479R	ST7_uc011knl.1_Missense_Mutation_p.K456R|ST7_uc003vio.2_Missense_Mutation_p.K456R|ST7_uc003viq.2_Missense_Mutation_p.K433R|ST7_uc011knm.1_Missense_Mutation_p.K436R|ST7_uc003vir.2_Missense_Mutation_p.K399R|ST7_uc011knn.1_Missense_Mutation_p.K427R	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	479						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CCCTTGGAAAAGGGGCACCTA	0.453													0	0	0	0.001168	0	3	192										G	116859168	A	G	116859168	3	3	120	1	0	0	0	0	1	0	0	0	15228	72	3	5	1490	5	ST7	7	116859168	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	44665315	116859168	42279495	87	35904										
CFTR	1080	broad.mit.edu	37	chr7	117232685	117232685	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaactggcttggaaataagtGaagaaattaacgaagaagac	10	4	0	4			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:117232685G>A	uc003vjd.2	+	14	2596	c.2464G>A	c.(2464-2466)GAA>AAA	p.E822K	CFTR_uc011knq.1_Missense_Mutation_p.E228K	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	822	Cytoplasmic (Potential).		E -> K (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GGAAATAAGTGAAGAAATTAA	0.403									Cystic_Fibrosis				0	0	0	0.005443	0	21	63										A	117232685	G	A	117232685	3	1	120	1	0	0	0	0	1	0	0	0	3294	1291	45	1	2518	1	CFTR	7	117232685	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	373517	117232685	41905978	88	35905										
C7orf58	79974	broad.mit.edu	37	chr7	120782154	120782154	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atagagaagaccgcccaagtCtgcccttgtttgaggccttc	10	12	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:120782154C>A	uc003vjq.3	+	16	2461	c.2014C>A	c.(2014-2016)CTG>ATG	p.L672M	C7orf58_uc003vjs.3_Missense_Mutation_p.L672M|C7orf58_uc003vjt.3_Missense_Mutation_p.L452M	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	672						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CCGCCCAAGTCTGCCCTTGTT	0.443													1	0	4.83814e-26	0.00361	5.2119e-26	58	135										A	120782154	C	A	120782154	3	1	120	1	0	0	0	0	1	0	0	0	2405	912	32	3	2072	3	C7orf58	7	120782154	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3549469	120782154	38356509	89	35906										
GPR37	2861	broad.mit.edu	37	chr7	124404068	124404068	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agccacttcttggtcagctcGtggaagatgaccagcggaag	13	10	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:124404068G>A	uc003vli.2	-	1	1614	c.963C>T	c.(961-963)CAC>CAT	p.H321H		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	321	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						TGGTCAGCTCGTGGAAGATGA	0.522													0	0	0	0.004482	0	6	192										A	124404068	G	A	124404068	2	1	120	1	0	0	0	0	0	0	0	1	6691	1136	40	2		2	GPR37	7	124404068	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	3621914	124404068	34734595	90	35907										
MKRN1	23608	broad.mit.edu	37	chr7	140159649	140159649	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agtggtccaactatcgatgaGagacttgaggaagcagcaag	13	7	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:140159649G>C	uc003vvt.2	-	3	627	c.402C>G	c.(400-402)CTC>CTG	p.L134L	MKRN1_uc003vvs.2_Silent_p.L70L|MKRN1_uc011krd.1_Intron|MKRN1_uc003vvv.3_Silent_p.L134L|MKRN1_uc003vvu.3_Silent_p.L70L	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	134							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CTATCGATGAGAGACTTGAGG	0.413													0	0	0	0.004878	0	32	87										C	140159649	G	C	140159649	2	2	120	1	0	0	0	0	0	0	0	1	9606	929	33	1		1	MKRN1	7	140159649	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	15755581	140159649	18979014	91	35908										
ZNF425	155054	broad.mit.edu	37	chr7	148802225	148802225	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttctcacactcactgcactgGaaccgcttcttctgacacag	6	15	4	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:148802225G>C	uc003wfj.2	-	4	811	c.738C>G	c.(736-738)TTC>TTG	p.F246L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	246	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CACTGCACTGGAACCGCTTCT	0.582													0	0	0	0.00632	0	24	57										C	148802225	G	C	148802225	3	2	120	1	0	0	0	0	1	0	0	0	17896	1165	41	1	1524	1	ZNF425	7	148802225	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	8642576	148802225	10336438	92	35909										
ZNF467	168544	broad.mit.edu	37	chr7	149463272	149463272	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctggggccattcgacctcctCttctgcctcctgatcttcgt	8	16	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:149463272C>G	uc003wgd.2	-	5	460	c.319G>C	c.(319-321)GAG>CAG	p.E107Q	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCGACCTCCTCTTCTGCCTCC	0.572													0	0	0	0.007835	0	34	44										G	149463272	C	G	149463272	3	3	120	1	0	0	0	0	1	0	0	0	17924	922	32	1	1472	1	ZNF467	7	149463272	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	661047	149463272	9675391	93	35910										
USP17L2	377630	broad.mit.edu	37	chr8	11995859	11995859	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggatgacatgaccaggactGtggagggcccatgtgatgtg	16	7	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:11995859G>A	uc003wvc.1	-	1	411	c.411C>T	c.(409-411)CAC>CAT	p.H137H	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	137					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						GACCAGGACTGTGGAGGGCCC	0.532													0	0	0	0.006122	0	12	29										A	11995859	G	A	11995859	2	1	120	1	0	0	0	0	0	0	0	1	17045	1368	48	2		2	USP17L2	8	11995859	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		11995859	134368163	94	35911										
ARFGEF1	10565	broad.mit.edu	37	chr8	68150646	68150646	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	taagagatccttctctgcctCgcactgttccagaaatgtat	7	11	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:68150646C>T	uc003xxo.1	-	22	3611	c.3221G>A	c.(3220-3222)CGA>CAA	p.R1074Q	ARFGEF1_uc003xxl.1_Missense_Mutation_p.R528Q|ARFGEF1_uc003xxn.1_Missense_Mutation_p.R57Q	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1074					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTCTCTGCCTCGCACTGTTCC	0.403													0	0	0	0.00361	0	41	84										T	68150646	C	T	68150646	3	4	120	1	0	0	0	0	1	0	0	0	852	884	31	1	2400	1	ARFGEF1	8	68150646	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	56154787	68150646	78213376	95	35912										
ARFGEF1	10565	broad.mit.edu	37	chr8	68150723	68150723	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tccaactgactgatgcacttCagaatcttaattacaaaaag	5	9	2	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:68150723C>T	uc003xxo.1	-	22	3534	c.3144G>A	c.(3142-3144)CTG>CTA	p.L1048L	ARFGEF1_uc003xxl.1_Silent_p.L502L|ARFGEF1_uc003xxn.1_Silent_p.L31L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1048					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGATGCACTTCAGAATCTTAA	0.368													0	0	0	0.008871	0	20	32										T	68150723	C	T	68150723	2	4	120	1	0	0	0	0	0	0	0	1	852	813	29	1		1	ARFGEF1	8	68150723	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	77	68150723	78213299	96	35913										
ZFHX4	79776	broad.mit.edu	37	chr8	77767807	77767807	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acaaagatggcgaccacgacCaaagcttttacatcacagat	7	11	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:77767807C>A	uc003yav.2	+	10	8902	c.8515C>A	c.(8515-8517)CAA>AAA	p.Q2839K	ZFHX4_uc003yau.1_Missense_Mutation_p.Q2884K|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q2839K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2839						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGACCACGACCAAAGCTTTTA	0.522										HNSCC(33;0.089)			1	0	1.90627e-21	0.012319	2.03606e-21	17	37										A	77767807	C	A	77767807	3	1	120	1	0	0	0	0	1	0	0	0	17632	595	21	4	8684	4	ZFHX4	8	77767807	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	9617084	77767807	68596215	97	35914										
PKIA	5569	broad.mit.edu	37	chr8	79513978	79513978	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tttcgtttttcttttgcagaAggtgaagaagatgcacaacg	10	6	1	4			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:79513978A>T	uc003yba.2	+	4	677	c.153A>T	c.(151-153)GAA>GAT	p.E51D	PKIA_uc003ybb.2_Missense_Mutation_p.E51D|PKIA_uc010lzo.2_Missense_Mutation_p.E51D	NM_006823	NP_006814	P61925	IPKA_HUMAN	cAMP-dependent protein kinase inhibitor alpha	51							cAMP-dependent protein kinase inhibitor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTTTTGCAGAAGGTGAAGAAG	0.383													0	0	0	0.002299	0	21	25										T	79513978	A	T	79513978	3	4	120	1	0	0	0	0	1	0	0	0	11973	86	3	5	159	5	PKIA	8	79513978	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	1746171	79513978	66850044	98	35915										
SPAG1	6674	broad.mit.edu	37	chr8	101251630	101251630	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gaaggaaaattgagattcaaGaggtatttgtatttgattat	10	1	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:101251630G>C	uc003yjh.1	+	17	2364	c.2278G>C	c.(2278-2280)GAG>CAG	p.E760Q	SPAG1_uc003yji.1_Missense_Mutation_p.E760Q	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	760					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TGAGATTCAAGAGGTATTTGT	0.353													0	0	0	0.004289	0	32	53										C	101251630	G	C	101251630	3	2	120	1	0	0	0	0	1	0	0	0	14975	943	33	1	2340	1	SPAG1	8	101251630	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	21737652	101251630	45112392	99	35916										
DPYS	1807	broad.mit.edu	37	chr8	105436562	105436562	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gatagagattaaaaattttgGctgcatttgtgctggtaact	10	4	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:105436562G>A	uc003yly.3	-	7	1277	c.1148C>T	c.(1147-1149)GCC>GTC	p.A383V		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	383					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAAAATTTTGGCTGCATTTGT	0.348													0	0	0	0.006214	0	9	80										A	105436562	G	A	105436562	3	1	120	1	0	0	0	0	1	0	0	0	4746	1203	42	2	423	2	DPYS	8	105436562	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	4184932	105436562	40927460	100	35917										
TRPS1	7227	broad.mit.edu	37	chr8	116616680	116616680	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtctgtcttggtcattgtctCtccttctgaacttttggcta	8	10	5	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:116616680C>T	uc003ynz.2	-	3	1936	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	TRPS1_uc011lhy.1_Missense_Mutation_p.E497K|TRPS1_uc003yny.2_Missense_Mutation_p.E506K|TRPS1_uc010mcy.2_Missense_Mutation_p.E493K	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	493					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTCATTGTCTCTCCTTCTGAA	0.463									Langer-Giedion_syndrome				0	0	0	0.006214	0	10	119										T	116616680	C	T	116616680	3	4	120	1	0	0	0	0	1	0	0	0	16590	922	32	1	2384	1	TRPS1	8	116616680	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	11180118	116616680	29747342	101	35918										
UNC13B	10497	broad.mit.edu	37	chr9	35400365	35400365	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gcccagatctgcagtctctaCgctatgccctgtctctgtac	8	15	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:35400365C>T	uc003zwq.2	+	36	4454	c.4162C>T	c.(4162-4164)CGC>TGC	p.R1388C	UNC13B_uc003zwr.2_Missense_Mutation_p.R1388C	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1388	MHD2.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GCAGTCTCTACGCTATGCCCT	0.522													0	0	0	0.00361	0	119	174										T	35400365	C	T	35400365	3	4	120	1	0	0	0	0	1	0	0	0	16982	536	19	2	4304	2	UNC13B	9	35400365	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		35400365	105813066	102	35919										
TJP2	9414	broad.mit.edu	37	chr9	71844153	71844153	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttcgtcctagtcctgaagatGaagcaatatatgggtatgta	10	6	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:71844153G>T	uc004ahe.2	+	10	1707	c.1507G>T	c.(1507-1509)GAA>TAA	p.E503*	TJP2_uc011lrs.1_Nonsense_Mutation_p.E480*|TJP2_uc011lrt.1_Nonsense_Mutation_p.E480*|TJP2_uc004ahd.2_Nonsense_Mutation_p.E503*|TJP2_uc004ahf.2_Nonsense_Mutation_p.E503*|TJP2_uc011lru.1_Nonsense_Mutation_p.E507*|TJP2_uc011lrv.1_Nonsense_Mutation_p.E525*	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	503					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						TCCTGAAGATGAAGCAATATA	0.423													1	0	6.23295e-54	0.00361	6.83175e-54	102	50										T	71844153	G	T	71844153	4	4	120	1	0	0	0	0	0	1	0	0	15927	1291	45	3	1702	3	TJP2	9	71844153	Nonsense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	36443788	71844153	69369278	103	35920										
GALNT12	79695	broad.mit.edu	37	chr9	101570311	101570311	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acatctacctcagcgaccgcAtctcactgcaccgccgcctg	7	19	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:101570311A>G	uc004ayz.2	+	1	331	c.331A>G	c.(331-333)ATC>GTC	p.I111V		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	111	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				CAGCGACCGCATCTCACTGCA	0.692													0	0	0	0.001168	0	5	5										G	101570311	A	G	101570311	3	3	120	1	0	0	0	0	1	0	0	0	6210	217	8	5	333	5	GALNT12	9	101570311	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	29726158	101570311	39643120	104	35921										
INVS	27130	broad.mit.edu	37	chr9	103002414	103002414	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctcctcttcactttgcagttGctgatgggaatgtgaccgtg	11	10	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:103002414G>T	uc004bap.1	+	6	900	c.688G>T	c.(688-690)GCT>TCT	p.A230S	INVS_uc010mta.1_Missense_Mutation_p.A134S|INVS_uc011lve.1_Missense_Mutation_p.A134S|INVS_uc004bao.1_Missense_Mutation_p.A230S|INVS_uc004baq.1_Missense_Mutation_p.A134S|INVS_uc004bar.1_Missense_Mutation_p.A134S|INVS_uc010mtb.1_5'UTR	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	230	ANK 7.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				CTTTGCAGTTGCTGATGGGAA	0.463													1	0	4.11147e-13	0.003755	4.29992e-13	32	59										T	103002414	G	T	103002414	3	4	120	1	0	0	0	0	1	0	0	0	7787	1319	46	4	706	4	INVS	9	103002414	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1432103	103002414	38211017	105	35922										
C9orf78	51759	broad.mit.edu	37	chr9	132590500	132590500	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tagtcatcagttgccttctcGttagcaggacgcttgcggtt	11	10	3	0	rs147768922	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:132590500G>A	uc004byp.2	-	9	882	c.810C>T	c.(808-810)AAC>AAT	p.N270N	C9orf78_uc004byo.2_Missense_Mutation_p.T185M	NM_016520	NP_057604	Q9NZ63	CI078_HUMAN	chromosome 9 open reading frame 78	270											0		Ovarian(14;0.00556)				TTGCCTTCTCGTTAGCAGGAC	0.413													0	0	0	0.00361	0	57	69										A	132590500	G	A	132590500	2	1	120	1	0	0	0	0	0	0	0	1	2496	1136	40	2		2	C9orf78	9	132590500	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	29588086	132590500	8622931	106	35923										
RXRA	6256	broad.mit.edu	37	chr9	137328351	137328351	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ccgcctgccggctctgcgctCcatcgggctcaaatgcctgg	12	17	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:137328351C>A	uc004cfb.2	+	10	1442	c.1280C>A	c.(1279-1281)TCC>TAC	p.S427Y	RXRA_uc004cfc.1_Missense_Mutation_p.S330Y	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607													1	0	3.47803e-31	0.00361	3.76287e-31	72	36										A	137328351	C	A	137328351	3	1	120	1	0	0	0	0	1	0	0	0	13763	855	30	3	1318	3	RXRA	9	137328351	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	4737851	137328351	3885080	107	35924										
ITGA8	8516	broad.mit.edu	37	chr10	15760899	15760899	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cccccaccaagacactcgctCtgcaaaagagttggagaaag	9	13	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:15760899C>G	uc001ioc.1	-	2	210	c.210_splice	c.e2-1	p.T70_splice	ITGA8_uc010qcb.1_Splice_Site_p.T70_splice	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor						cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GACACTCGCTCTGCAAAAGAG	0.607													0	0	0	0.00874	0	39	55										G	15760899	C	G	15760899	5	3	120	1	0	0	0	0	0	0	1	0	7882	927	32	1	3098	1	ITGA8	10	15760899	Splice_Site	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		15760899	119773848	108	35925										
FAM13C	220965	broad.mit.edu	37	chr10	61012730	61012730	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gttgttggcttccctgtggaCggtcttcatcagagtcctct	11	11	4	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:61012730C>T	uc001jkn.2	-	13	1495	c.1361G>A	c.(1360-1362)CGT>CAT	p.R454H	FAM13C_uc001jko.2_Missense_Mutation_p.R356H|FAM13C_uc010qid.1_Missense_Mutation_p.R370H|FAM13C_uc010qie.1_Missense_Mutation_p.R371H|FAM13C_uc010qif.1_Missense_Mutation_p.R476H	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	454										ovary(2)	2						TCCCTGTGGACGGTCTTCATC	0.483													0	0	0	0.003271	0	29	53										T	61012730	C	T	61012730	3	4	120	1	0	0	0	0	1	0	0	0	5454	536	19	2	408	2	FAM13C	10	61012730	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	45251831	61012730	74522017	109	35926										
PDE6C	5146	broad.mit.edu	37	chr10	95396758	95396758	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cttttacattttagaaatttCaagagaagttaaatgttgat	6	3	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:95396758C>G	uc001kiu.3	+	11	1558	c.1420C>G	c.(1420-1422)CAA>GAA	p.Q474E		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	474					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TTAGAAATTTCAAGAGAAGTT	0.289													0	0	0	0.008871	0	17	10										G	95396758	C	G	95396758	3	3	120	1	0	0	0	0	1	0	0	0	11647	827	29	1	1462	1	PDE6C	10	95396758	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	34384028	95396758	40137989	110	35927										
NRAP	4892	broad.mit.edu	37	chr10	115401142	115401142	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acgttgcttgccaggctgccAactttcatagcatgcagagt	10	11	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:115401142A>G	uc001laj.2	-	13	1469	c.1305T>C	c.(1303-1305)GTT>GTC	p.V435V	NRAP_uc001lak.2_Silent_p.V400V|NRAP_uc001lal.3_Silent_p.V435V	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	435	Nebulin 10.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CCAGGCTGCCAACTTTCATAG	0.458													0	0	0	0.00361	0	51	26										G	115401142	A	G	115401142	2	3	120	1	0	0	0	0	0	0	0	1	10638	117	5	5		5	NRAP	10	115401142	Silent	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	20004384	115401142	20133605	111	35928										
SEC23IP	11196	broad.mit.edu	37	chr10	121652431	121652431	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agtcacccaggcctccgcttCtccggcctccctgctcttac	7	20	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:121652431C>G	uc001leu.1	+	1	209	c.137C>G	c.(136-138)TCT>TGT	p.S46C	SEC23IP_uc010qtc.1_Missense_Mutation_p.L13V	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	46	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GCCTCCGCTTCTCCGGCCTCC	0.622													0	0	0	0.00361	0	50	9										G	121652431	C	G	121652431	3	3	120	1	0	0	0	0	1	0	0	0	13993	913	32	1	139	1	SEC23IP	10	121652431	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	6251289	121652431	13882316	112	35929										
TACC2	10579	broad.mit.edu	37	chr10	123845062	123845062	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agcatgtcaaaggcatccagGagcttctgaagcagctgatg	12	9	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:123845062G>C	uc001lfv.2	+	4	3407	c.3047G>C	c.(3046-3048)GGA>GCA	p.G1016A	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.G1016A|TACC2_uc010qtv.1_Missense_Mutation_p.G1016A	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1016						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGCATCCAGGAGCTTCTGAA	0.557													0	0	0	0.007413	0	16	10										C	123845062	G	C	123845062	3	2	120	1	0	0	0	0	1	0	0	0	15499	1174	41	1	3057	1	TACC2	10	123845062	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	2192631	123845062	11689685	113	35930										
MUC5B	727897	broad.mit.edu	37	chr11	1268537	1268537	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agcctggacttcggccacctCgggcatcttgggcaccaccc	11	17	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:1268537C>A	uc009ycr.1	+	50	12137	c.12011C>A	c.(12010-12012)TCG>TAG	p.S4004*	MUC5B_uc001ltb.2_Nonsense_Mutation_p.S3479*	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3476	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCGGCCACCTCGGGCATCTTG	0.672													1	0	2.87052e-16	0.005524	3.02731e-16	24	130										A	1268537	C	A	1268537	4	1	120	1	0	0	0	0	0	1	0	0	9979	893	31	3	10558	3	MUC5B	11	1268537	Nonsense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		1268537	133737979	114	35931										
TRPM5	29850	broad.mit.edu	37	chr11	2443523	2443523	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gcaggtcaaagagcacagacGgggccactccgctcggcacc	13	15	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:2443523G>A	uc001lwm.3	-	2	155	c.146C>T	c.(145-147)CCG>CTG	p.P49L	TRPM5_uc010qxl.1_Missense_Mutation_p.P49L|TRPM5_uc009ydn.2_Missense_Mutation_p.P49L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	49	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GAGCACAGACGGGGCCACTCC	0.662													0	0	0	0.004289	0	33	60										A	2443523	G	A	2443523	3	1	120	1	0	0	0	0	1	0	0	0	16586	1116	39	2	3443	2	TRPM5	11	2443523	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1174986	2443523	132562993	115	35932										
NAP1L4	4676	broad.mit.edu	37	chr11	2975840	2975840	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acggaaaaagtgtccaatttCaaaatcagaggctaatgtga	9	6	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:2975840C>A	uc001lxc.2	-	12	1093	c.952G>T	c.(952-954)GAA>TAA	p.E318*	NAP1L4_uc001lxb.2_5'Flank|NAP1L4_uc009ydt.2_RNA|NAP1L4_uc010qxm.1_Nonsense_Mutation_p.E318*|NAP1L4_uc010qxn.1_Nonsense_Mutation_p.E318*	NM_005969	NP_005960	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	318					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			ovary(1)	1		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		TGTCCAATTTCAAAATCAGAG	0.448													1	0	7.11191e-15	0.002836	7.46899e-15	32	37										A	2975840	C	A	2975840	4	1	120	1	0	0	0	0	0	1	0	0	10159	835	29	3	191	3	NAP1L4	11	2975840	Nonsense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	532317	2975840	132030676	116	35933										
ZNF195	7748	broad.mit.edu	37	chr11	3380678	3380678	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cattcgtcacatttgtagggCttctctccagtatgggtttt	9	9	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:3380678C>T	uc001lxt.2	-	6	1738	c.1560G>A	c.(1558-1560)AAG>AAA	p.K520K	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.K497K|ZNF195_uc001lxs.2_Silent_p.K448K|ZNF195_uc010qxr.1_Silent_p.K501K|ZNF195_uc009ydz.2_Silent_p.K475K|ZNF195_uc001lxu.2_Silent_p.K452K	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGCTTCTCTCCAG	0.403													0	0	0	0.009096	0	4	171										T	3380678	C	T	3380678	2	4	120	1	0	0	0	0	0	0	0	1	17755	796	28	2		2	ZNF195	11	3380678	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	404838	3380678	131625838	117	35934										
HPS5	11234	broad.mit.edu	37	chr11	18322409	18322409	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	caaagaagaacttgaacattCtgaggaatgaaaatataaat	7	4	1	5			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:18322409C>T	uc001mod.1	-	9	1229	c.951G>A	c.(949-951)CAG>CAA	p.Q317Q	HPS5_uc001moe.1_Silent_p.Q203Q|HPS5_uc001mof.1_Silent_p.Q203Q	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	317						cytosol				ovary(1)|pancreas(1)|skin(1)	3						CTTGAACATTCTGAGGAATGA	0.323									Hermansky-Pudlak_syndrome				0	0	0	0.003954	0	20	19										T	18322409	C	T	18322409	2	4	120	1	0	0	0	0	0	0	0	1	7342	912	32	1		1	HPS5	11	18322409	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	14941731	18322409	116684107	118	35935										
ARHGAP1	392	broad.mit.edu	37	chr11	46700690	46700690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggccttgagggtgatggccGcatccttggcccacagcagg	15	12	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:46700690G>A	uc001ndd.2	-	13	1286	c.1217C>T	c.(1216-1218)GCG>GTG	p.A406V		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	406	Rho-GAP.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		GGTGATGGCCGCATCCTTGGC	0.552													0	0	0	0.009096	0	4	107										A	46700690	G	A	46700690	3	1	120	1	0	0	0	0	1	0	0	0	861	1087	38	2	106	2	ARHGAP1	11	46700690	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	28378281	46700690	88305826	119	35936										
OR4X2	119764	broad.mit.edu	37	chr11	48267009	48267009	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tatgaccactatgtggccatCtgcaagcccctcagctacac	7	15	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:48267009C>T	uc001ngs.1	+	1	354	c.354C>T	c.(352-354)ATC>ATT	p.I118I		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	118	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGTGGCCATCTGCAAGCCCC	0.512													0	0	0	0.011902	0	44	47										T	48267009	C	T	48267009	2	4	120	1	0	0	0	0	0	0	0	1	11085	903	32	1		1	OR4X2	11	48267009	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	1566319	48267009	86739507	120	35937										
VWCE	220001	broad.mit.edu	37	chr11	61039180	61039180	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aactcacaggggtcaccaggCgaccagatctgtccaatcgg	11	13	3	1	rs141642839		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:61039180C>T	uc001nra.2	-	14	2031	c.1752G>A	c.(1750-1752)TCG>TCA	p.S584S	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	584	VWFC 4.					extracellular region	calcium ion binding			ovary(1)	1						GGTCACCAGGCGACCAGATCT	0.557													0	0	0	0.001984	0	6	40										T	61039180	C	T	61039180	2	4	120	1	0	0	0	0	0	0	0	1	17242	755	27	2		2	VWCE	11	61039180	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	12772171	61039180	73967336	121	35938										
GANAB	23193	broad.mit.edu	37	chr11	62397103	62397103	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaggccctggccaggacaaaGgggcgttccatgcccccaga	13	14	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:62397103G>C	uc001nub.2	-	15	1824	c.1791C>G	c.(1789-1791)CCC>CCG	p.P597P	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Silent_p.P619P|GANAB_uc001nuc.2_Silent_p.P500P|GANAB_uc010rma.1_Silent_p.P505P|GANAB_uc010rmb.1_Silent_p.P483P	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	597					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CCAGGACAAAGGGGCGTTCCA	0.597													0	0	0	0.00499	0	14	35										C	62397103	G	C	62397103	2	2	120	1	0	0	0	0	0	0	0	1	6233	987	35	4		4	GANAB	11	62397103	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1357923	62397103	72609413	122	35939										
DKFZp761E198	91056	broad.mit.edu	37	chr11	65547046	65547046	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	accagctgcggcttgaagagTgccggtggctgtccctgcag	15	12	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:65547046T>C	uc001ofo.3	-	1	777	c.747A>G	c.(745-747)GCA>GCG	p.A249A		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	249	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		GCTTGAAGAGTGCCGGTGGCT	0.642													0	0	0	0.001168	0	5	6										C	65547046	T	C	65547046	2	2	120	1	0	0	0	0	0	0	0	1	4543	1683	59	5		5	DKFZp761E198	11	65547046	Silent	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	3149943	65547046	69459470	123	35940										
CCDC87	55231	broad.mit.edu	37	chr11	66360121	66360121	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aagaagagctgctcgctgctCagcagcacgtaggcctcgag	13	12	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:66360121C>T	uc001oiq.3	-	1	434	c.366G>A	c.(364-366)CTG>CTA	p.L122L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	122										ovary(1)|skin(1)	2						GCTCGCTGCTCAGCAGCACGT	0.627											OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	48	57										T	66360121	C	T	66360121	2	4	120	1	0	0	0	0	0	0	0	1	2862	813	29	1		1	CCDC87	11	66360121	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	813075	66360121	68646395	124	35941										
LRP5	4041	broad.mit.edu	37	chr11	68171050	68171050	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggacttcatctactggactGactggcagcgccgcagcatc	12	13	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:68171050G>C	uc001ont.2	+	8	1759	c.1684G>C	c.(1684-1686)GAC>CAC	p.D562H	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	562	YWTD 8.|Beta-propeller 2.|LDL-receptor class B 10.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CTACTGGACTGACTGGCAGCG	0.597													0	0	0	0.005524	0	35	61										C	68171050	G	C	68171050	3	2	120	1	0	0	0	0	1	0	0	0	8960	1290	45	1	1714	1	LRP5	11	68171050	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1810929	68171050	66835466	125	35942										
MYO7A	4647	broad.mit.edu	37	chr11	76873903	76873903	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cccctccactccccagggcaCagacaccaccatgttacaca	5	20	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:76873903C>G	uc001oyb.2	+	14	1831	c.1559C>G	c.(1558-1560)ACA>AGA	p.T520R	MYO7A_uc010rsl.1_Missense_Mutation_p.T520R|MYO7A_uc010rsm.1_Missense_Mutation_p.T509R|MYO7A_uc001oyc.2_Missense_Mutation_p.T520R	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	520	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCCCAGGGCACAGACACCACC	0.587													0	0	0	0.00361	0	70	73										G	76873903	C	G	76873903	3	3	120	1	0	0	0	0	1	0	0	0	10082	478	17	4	1609	4	MYO7A	11	76873903	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	8702853	76873903	58132613	126	35943										
FAT3	120114	broad.mit.edu	37	chr11	92616246	92616246	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aacaagagcaatggcatcccGttccggaacctgcgcggcag	12	13	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:92616246G>A	uc001pdj.3	+	23	12641	c.12624G>A	c.(12622-12624)CCG>CCA	p.P4208P	FAT3_uc001pdi.3_Silent_p.P648P	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4208	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGGCATCCCGTTCCGGAACC	0.657										TCGA Ovarian(4;0.039)			0	0	0	0.004007	0	14	96										A	92616246	G	A	92616246	2	1	120	1	0	0	0	0	0	0	0	1	5691	1132	40	2		2	FAT3	11	92616246	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	15742343	92616246	42390270	127	35944										
HYOU1	10525	broad.mit.edu	37	chr11	118919580	118919580	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gacgccctcaggccctgcctCtgccttctcacttggtttct	8	17	4	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:118919580C>T	uc001puu.2	-	18	2204	c.2011G>A	c.(2011-2013)GAG>AAG	p.E671K	HYOU1_uc001put.2_Missense_Mutation_p.E636K|HYOU1_uc010ryu.1_Missense_Mutation_p.E629K|HYOU1_uc010ryv.1_Missense_Mutation_p.E560K|HYOU1_uc001pux.3_Missense_Mutation_p.E671K|HYOU1_uc010ryw.1_RNA	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	671						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GGCCCTGCCTCTGCCTTCTCA	0.612													0	0	0	0.00361	0	46	40										T	118919580	C	T	118919580	3	4	120	1	0	0	0	0	1	0	0	0	7470	922	32	1	1024	1	HYOU1	11	118919580	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	26303334	118919580	16086936	128	35945										
CCDC153	283152	broad.mit.edu	37	chr11	119061144	119061144	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atggctctcagcttggccaaGagcctgtccagactgtcctg	11	13	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:119061144G>C	uc010rze.1	-	7	586	c.498C>G	c.(496-498)CTC>CTG	p.L166L		NM_001145018	NP_001138490	Q494R4	CC153_HUMAN	coiled-coil domain containing 153	166											0						GCTTGGCCAAGAGCCTGTCCA	0.562													0	0	0	0.00361	0	74	56										C	119061144	G	C	119061144	2	2	120	1	0	0	0	0	0	0	0	1	2787	929	33	1		1	CCDC153	11	119061144	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	141564	119061144	15945372	129	35946										
TECTA	7007	broad.mit.edu	37	chr11	120989224	120989224	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agccacactaccacacttttGacggcttcctcttccacttc	4	17	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:120989224G>C	uc010rzo.1	+	6	1000	c.1000G>C	c.(1000-1002)GAC>CAC	p.D334H		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	334	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCACACTTTTGACGGCTTCCT	0.557													0	0	0	0.003163	0	15	93										C	120989224	G	C	120989224	3	2	120	1	0	0	0	0	1	0	0	0	15744	1290	45	1	1022	1	TECTA	11	120989224	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1928080	120989224	14017292	130	35947										
IGSF9B	22997	broad.mit.edu	37	chr11	133789947	133789947	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctgctgcaggaggcccgggcGaggccgggcacgggcggcga	21	13	0	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:133789947G>A	uc001qgx.3	-	18	3904	c.3673C>T	c.(3673-3675)CGC>TGC	p.R1225C		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1225	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGGCCCGGGCGAGGCCGGGCA	0.677													0	0	0	0.009535	0	27	18										A	133789947	G	A	133789947	3	1	120	1	0	0	0	0	1	0	0	0	7606	1058	37	1	384	1	IGSF9B	11	133789947	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	12800723	133789947	1216569	131	35948										
CHD4	1108	broad.mit.edu	37	chr12	6707456	6707456	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tttcacaaagaactgccgctCtggccgcccctccaagggct	9	16	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:6707456C>T	uc001qpo.2	-	11	1782	c.1618G>A	c.(1618-1620)GAG>AAG	p.E540K	CHD4_uc001qpn.2_Missense_Mutation_p.E533K|CHD4_uc001qpp.2_Missense_Mutation_p.E537K	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	540	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AACTGCCGCTCTGGCCGCCCC	0.572													0	0	0	0.00361	0	123	115										T	6707456	C	T	6707456	3	4	120	1	0	0	0	0	1	0	0	0	3327	922	32	1	4240	1	CHD4	12	6707456	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		6707456	127144439	132	35949										
KLRC4	8302	broad.mit.edu	37	chr12	10560257	10560257	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tttcttcctcattatctataGaaagcagatcagagttcttc	5	9	5	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:10560257G>C	uc001qye.2	-	4	654	c.472C>G	c.(472-474)CTA>GTA	p.L158V	KLRK1_uc001qyc.2_5'UTR|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_5'UTR	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	158	Extracellular (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						ATTATCTATAGAAAGCAGATC	0.274													0	0	0	0.00361	0	61	180										C	10560257	G	C	10560257	3	2	120	1	0	0	0	0	1	0	0	0	8418	933	33	1	8	1	KLRC4	12	10560257	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	3852801	10560257	123291638	133	35950										
ANO6	196527	broad.mit.edu	37	chr12	45823019	45823019	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gagaatcacctcaaagatatGacgaaaaatatgggggtgat	11	5	2	4			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:45823019G>C	uc001roo.2	+	20	2993	c.2658G>C	c.(2656-2658)ATG>ATC	p.M886I	ANO6_uc010sld.1_Intron|ANO6_uc010sle.1_Intron|ANO6_uc010slf.1_Missense_Mutation_p.M907I|ANO6_uc010slg.1_Missense_Mutation_p.M868I	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	886	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						TCAAAGATATGACGAAAAATA	0.388													0	0	0	0.004007	0	13	36										C	45823019	G	C	45823019	3	2	120	1	0	0	0	0	1	0	0	0	701	1290	45	1	2756	1	ANO6	12	45823019	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	35262762	45823019	88028876	134	35951										
SLC38A2	54407	broad.mit.edu	37	chr12	46757539	46757540	+	Frame_Shift_Ins	INS	-	-	A													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aggtatccaaagagggcggcINSaagcagatacatgagaaaca							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:46757539_46757540insA	uc001rpg.2	-	12	1463_1464	c.1023_1024insT	c.(1021-1026)CTTGCCfs	p.L341fs	SLC38A2_uc010sli.1_Frame_Shift_Ins_p.L179fs|SLC38A2_uc001rph.2_Frame_Shift_Ins_p.L241fs	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	341_342	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		AAGAGGGCGGCAAGCAGATACA	0.332																		49	46	---	---								A	46757540	-	A	46757539	7	5	120	1	0	1	1	0	0	0	0	0	14604	710	25	0	516	0	SLC38A2	12	46757539	Frame_Shift_Ins	INS	-	TCGA-GV-A3QH-01A-11D-A21Z-08	934520	46757539	87094356	135	35952										
ANKRD52	283373	broad.mit.edu	37	chr12	56641847	56641847	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cacttgcgcttgcgctccttGatgagggcagaggcgccgtg	15	12	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:56641847G>C	uc001skm.3	-	18	2028	c.1938C>G	c.(1936-1938)ATC>ATG	p.I646M		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	646	ANK 18.						protein binding			ovary(2)	2						TGCGCTCCTTGATGAGGGCAG	0.637													0	0	0	0.008291	0	10	15										C	56641847	G	C	56641847	3	2	120	1	0	0	0	0	1	0	0	0	678	1280	45	1	1336	1	ANKRD52	12	56641847	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	9884308	56641847	77210048	136	35953										
GNS	2799	broad.mit.edu	37	chr12	65110565	65110565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcgagtcctgacactgccgcGattgctgaacatgagacggg	13	11	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:65110565G>A	uc001ssg.3	-	14	1785	c.1615C>T	c.(1615-1617)CGC>TGC	p.R539C	GNS_uc001ssf.2_Missense_Mutation_p.R483C|GNS_uc010ssq.1_Missense_Mutation_p.R571C|GNS_uc010ssr.1_Missense_Mutation_p.R519C	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	539						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		ACACTGCCGCGATTGCTGAAC	0.473													0	0	0	0.010504	0	15	53										A	65110565	G	A	65110565	3	1	120	1	0	0	0	0	1	0	0	0	6550	1058	37	1	47	1	GNS	12	65110565	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	8468718	65110565	68741330	137	35954										
TMTC2	160335	broad.mit.edu	37	chr12	83081401	83081401	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtgagcagcgctctggggctCgccttgtatctcaacaccct	11	14	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:83081401C>T	uc001szt.2	+	1	468	c.36C>T	c.(34-36)CTC>CTT	p.L12L	TMTC2_uc001szr.1_Silent_p.L12L|TMTC2_uc001szs.1_Silent_p.L12L|TMTC2_uc010suk.1_5'UTR	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	12						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CTCTGGGGCTCGCCTTGTATC	0.627											OREG0022010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001368	0	11	25										T	83081401	C	T	83081401	2	4	120	1	0	0	0	0	0	0	0	1	16258	871	31	1		1	TMTC2	12	83081401	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	17970836	83081401	50770494	138	35955										
OAS2	4939	broad.mit.edu	37	chr12	113440781	113440781	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggccaccttctggataagttCatcaaggagtttctccagcc	9	12	4	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:113440781C>A	uc001tuj.2	+	6	1193	c.1053C>A	c.(1051-1053)TTC>TTA	p.F351L	OAS2_uc001tui.1_Missense_Mutation_p.F351L	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	351	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						TGGATAAGTTCATCAAGGAGT	0.507													1	0	2.37301e-105	0.00361	2.63551e-105	169	189										A	113440781	C	A	113440781	3	1	120	1	0	0	0	0	1	0	0	0	10800	825	29	3	1146	3	OAS2	12	113440781	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	30359380	113440781	20411114	139	35956										
WSB2	55884	broad.mit.edu	37	chr12	118480669	118480669	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtttattcaggtcccagatgCgaagagtcttatcccgtgac	10	10	2	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:118480669C>T	uc001twr.2	-	4	634	c.536G>A	c.(535-537)CGC>CAC	p.R179H	WSB2_uc010sza.1_5'UTR|WSB2_uc010szb.1_Intron|WSB2_uc009zws.1_Missense_Mutation_p.R179H	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	179	WD 2.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCCCAGATGCGAAGAGTCTT	0.458													0	0	0	0.009718	0	39	146										T	118480669	C	T	118480669	3	4	120	1	0	0	0	0	1	0	0	0	17402	768	27	2	702	2	WSB2	12	118480669	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	5039888	118480669	15371226	140	35957										
GALNT9	50614	broad.mit.edu	37	chr12	132685671	132685671	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cctcgggggaggtgctacctCtccgtacgtgagggtgttgt	16	10	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:132685671C>G	uc001ukc.3	-	8	1515	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q	GALNT9_uc009zyr.2_Missense_Mutation_p.E241Q|GALNT9_uc001ukb.2_Missense_Mutation_p.E324Q|GALNT9_uc001uka.2_Missense_Mutation_p.E101Q	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	467	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		GGTGCTACCTCTCCGTACGTG	0.607													0	0	0	0.004482	0	6	21										G	132685671	C	G	132685671	3	3	120	1	0	0	0	0	1	0	0	0	6220	922	32	1	428	1	GALNT9	12	132685671	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	14205002	132685671	1166224	141	35958										
FRY	10129	broad.mit.edu	37	chr13	32821530	32821530	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtcagccagccttgttttacCttcataccagcacagtgacc	7	14	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr13:32821530C>T	uc001utx.2	+	48	7395	c.6899C>T	c.(6898-6900)CCT>CTT	p.P2300L	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTTGTTTTACCTTCATACCAG	0.433													0	0	0	0.00361	0	67	88										T	32821530	C	T	32821530	3	4	120	1	0	0	0	0	1	0	0	0	6063	681	24	2	7089	2	FRY	13	32821530	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		32821530	82348348	142	35959										
FREM2	341640	broad.mit.edu	37	chr13	39262725	39262725	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgaactggaattggaggtagTggatctagaaggagcagctt	15	4	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr13:39262725T>A	uc001uwv.2	+	1	1553	c.1244T>A	c.(1243-1245)GTG>GAG	p.V415E		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	415	CSPG 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TTGGAGGTAGTGGATCTAGAA	0.532													0	0	0	0.007413	0	18	55										A	39262725	T	A	39262725	3	1	120	1	0	0	0	0	1	0	0	0	6045	1696	59	5	1246	5	FREM2	13	39262725	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	6441195	39262725	75907153	143	35960										
LRCH1	23143	broad.mit.edu	37	chr13	47243183	47243186	+	Frame_Shift_Del	DEL	CCTG	CCTG	-													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agtcgaaatcagctgtccgcCctgcctgcctgcctgtgtgg							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr13:47243183_47243186delCCTG	uc001vbj.2	+	3	707_710	c.471_474delCCTG	c.(469-474)GCCCTGfs	p.A157fs	LRCH1_uc010acp.2_Frame_Shift_Del_p.A157fs|LRCH1_uc001vbk.2_Frame_Shift_Del_p.A157fs|LRCH1_uc001vbl.3_Frame_Shift_Del_p.A157fs	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	157_158	LRR 3.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		AGCTGTCCGCCCTGCCTGCCTGCC	0.436																		7	318	---	---								-	47243186	CCTG	-	47243183	7	5	120	1	0	1	0	1	0	0	0	0	8932	610	22	0	481	0	LRCH1	13	47243183	Frame_Shift_Del	DEL	CCTG	TCGA-GV-A3QH-01A-11D-A21Z-08	7980458	47243183	67926695	144	35961										
OR4K14	122740	broad.mit.edu	37	chr14	20482654	20482654	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtggagagtgctttggatgtGctaccggcagcacgctgtct	15	9	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:20482654G>T	uc010tky.1	-	1	699	c.699C>A	c.(697-699)AGC>AGA	p.S233R		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTTTGGATGTGCTACCGGCAG	0.502													1	0	0.00307968	0.00308	0.00310442	8	15										T	20482654	G	T	20482654	3	4	120	1	0	0	0	0	1	0	0	0	11069	1310	46	4	236	4	OR4K14	14	20482654	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		20482654	86866886	145	35962										
SLC7A8	23428	broad.mit.edu	37	chr14	23596404	23596404	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cctcagggctggggctgcccCgccacgtccttgtccttcgt	12	17	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:23596404C>T	uc001wiz.2	-	11	2316	c.1590G>A	c.(1588-1590)GCG>GCA	p.A530A	SLC7A8_uc001wiw.2_Silent_p.A147A|SLC7A8_uc001wix.2_Silent_p.A327A|SLC7A8_uc010tnk.1_Silent_p.A306A|SLC7A8_uc010tnl.1_Silent_p.A425A|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_3'UTR	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	530					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GGGGCTGCCCCGCCACGTCCT	0.617													0	0	0	0.003271	0	27	74										T	23596404	C	T	23596404	2	4	120	1	0	0	0	0	0	0	0	1	14704	639	23	2		2	SLC7A8	14	23596404	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3113750	23596404	83753136	146	35963										
CLEC14A	161198	broad.mit.edu	37	chr14	38724762	38724762	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gcatcgcatctccttccagcCtgcgggctcgaccccaccgg	10	19	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:38724762C>T	uc001wum.1	-	1	813	c.466G>A	c.(466-468)GGC>AGC	p.G156S		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	156	Extracellular (Potential).|C-type lectin.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCCTTCCAGCCTGCGGGCTCG	0.572													0	0	0	0.003755	0	30	32										T	38724762	C	T	38724762	3	4	120	1	0	0	0	0	1	0	0	0	3499	681	24	2	1010	2	CLEC14A	14	38724762	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	15128358	38724762	68624778	147	35964										
DAAM1	23002	broad.mit.edu	37	chr14	59820639	59820639	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	caatcgctgtacttcaaaaaGaagtttgcagagcgtgtggc	11	8	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:59820639G>C	uc001xdz.1	+	20	2468	c.2343G>C	c.(2341-2343)AAG>AAC	p.K781N	DAAM1_uc001xea.1_Missense_Mutation_p.K771N|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	781	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ACTTCAAAAAGAAGTTTGCAG	0.348													0	0	0	0.00245	0	11	47										C	59820639	G	C	59820639	3	2	120	1	0	0	0	0	1	0	0	0	4215	933	33	1	2417	1	DAAM1	14	59820639	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	21095877	59820639	47528901	148	35965										
VTI1B	10490	broad.mit.edu	37	chr14	68120200	68120200	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ccgacttttgctcaagttttCacttgtgtttaccagctgag	8	10	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:68120200C>T	uc001xjt.2	-	5	952	c.556G>A	c.(556-558)GAA>AAA	p.E186K	VTI1B_uc010aqp.2_Missense_Mutation_p.E125K|VTI1B_uc001xju.2_Missense_Mutation_p.E145K	NM_006370	NP_006361	Q9UEU0	VTI1B_HUMAN	vesicle transport through interaction with	186	Potential.|Cytoplasmic (Potential).				cell proliferation|cellular membrane fusion|intracellular protein transport|vesicle docking involved in exocytosis	endomembrane system|integral to membrane					0				all cancers(60;0.000344)|OV - Ovarian serous cystadenocarcinoma(108;0.00212)|BRCA - Breast invasive adenocarcinoma(234;0.00941)		CTCAAGTTTTCACTTGTGTTT	0.333													0	0	0	0.00245	0	12	46										T	68120200	C	T	68120200	3	4	120	1	0	0	0	0	1	0	0	0	17233	835	29	1	150	1	VTI1B	14	68120200	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	8299561	68120200	39229340	149	35966										
SIPA1L1	26037	broad.mit.edu	37	chr14	72196849	72196849	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gccttgcacagaacactgtcGgacgagagcatttacaatag	10	10	0	2	rs141905323		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:72196849G>A	uc001xms.2	+	18	5103	c.4755G>A	c.(4753-4755)TCG>TCA	p.S1585S	SIPA1L1_uc001xmt.2_Silent_p.S1564S|SIPA1L1_uc001xmu.2_Silent_p.S1564S|SIPA1L1_uc001xmv.2_Silent_p.S1585S|SIPA1L1_uc010ttm.1_Silent_p.S1039S|SIPA1L1_uc001xmw.2_Silent_p.S350S	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1585					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAACACTGTCGGACGAGAGCA	0.557													0	0	0	0.001984	0	6	88										A	72196849	G	A	72196849	2	1	120	1	0	0	0	0	0	0	0	1	14329	1103	39	2		2	SIPA1L1	14	72196849	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	4076649	72196849	35152691	150	35967										
BTBD7	55727	broad.mit.edu	37	chr14	93714878	93714878	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctctcttagcactcgaatctGaatttcatagctgacagtgg	8	10	3	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:93714878G>C	uc001ybo.2	-	9	2391	c.2065C>G	c.(2065-2067)CAG>GAG	p.Q689E	BTBD7_uc010aur.2_Missense_Mutation_p.Q214E|BTBD7_uc010two.1_Missense_Mutation_p.Q509E|BTBD7_uc001ybp.2_Missense_Mutation_p.Q338E	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	689										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTCGAATCTGAATTTCATAG	0.517													0	0	0	0.00623	0	29	32										C	93714878	G	C	93714878	3	2	120	1	0	0	0	0	1	0	0	0	1546	1299	45	1	1345	1	BTBD7	14	93714878	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	21518029	93714878	13634662	151	35968										
DICER1	23405	broad.mit.edu	37	chr14	95562743	95562743	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gatagcacattgcatcccaaGagctgtagtcaaaatcctca	7	11	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:95562743G>C	uc001ydw.2	-	24	4696	c.4514C>G	c.(4513-4515)TCT>TGT	p.S1505C	DICER1_uc010avh.1_Missense_Mutation_p.S403C|DICER1_uc001ydv.2_Missense_Mutation_p.S1495C|DICER1_uc001ydx.2_Missense_Mutation_p.S1505C|DICER1_uc001ydy.1_Missense_Mutation_p.S357C	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1505					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGCATCCCAAGAGCTGTAGTC	0.408			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.00333	0	24	55										C	95562743	G	C	95562743	3	2	120	1	0	0	0	0	1	0	0	0	4521	942	33	1	1274	1	DICER1	14	95562743	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1847865	95562743	11786797	152	35969										
APBA2	321	broad.mit.edu	37	chr15	29346371	29346371	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggcctccctgaggaggaggAgggcatcacctactacatcc	13	13	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:29346371A>G	uc001zck.2	+	3	491	c.284A>G	c.(283-285)GAG>GGG	p.E95G	APBA2_uc010azj.2_Missense_Mutation_p.E95G|APBA2_uc010uat.1_Missense_Mutation_p.E95G|APBA2_uc001zcl.2_Missense_Mutation_p.E95G|APBA2_uc010uas.1_Missense_Mutation_p.E95G	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	95	Poly-Glu.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GAGGAGGAGGAGGGCATCACC	0.607													0	0	0	0.009096	0	3	170										G	29346371	A	G	29346371	3	3	120	1	0	0	0	0	1	0	0	0	757	304	11	5	286	5	APBA2	15	29346371	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08		29346371	73185021	153	35970										
TMEM87A	25963	broad.mit.edu	37	chr15	42512293	42512293	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cagcataggctccttttgttCatcctcctcctcttcctcag	5	16	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:42512293C>T	uc010udd.1	-	16	1603	c.1444G>A	c.(1444-1446)GAA>AAA	p.E482K		NM_015497	NP_056312	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A isoform 1	482	Poly-Glu.					integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		TCCTTTTGTTCATCCTCCTCC	0.318													0	0	0	0.004289	0	27	91										T	42512293	C	T	42512293	3	4	120	1	0	0	0	0	1	0	0	0	16207	835	29	1	243	1	TMEM87A	15	42512293	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	13165922	42512293	60019099	154	35971										
DENND4A	10260	broad.mit.edu	37	chr15	66015201	66015201	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cttacattttgccaattgctGatgcaaattattcagtgtgt	7	7	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:66015201G>A	uc002aph.2	-	12	1951	c.1573C>T	c.(1573-1575)CAG>TAG	p.Q525*	DENND4A_uc002api.2_Nonsense_Mutation_p.Q525*|DENND4A_uc002apj.3_Nonsense_Mutation_p.Q525*|DENND4A_uc010ujj.1_Nonsense_Mutation_p.Q525*	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GCCAATTGCTGATGCAAATTA	0.308													0	0	0	0.00308	0	7	27										A	66015201	G	A	66015201	4	1	120	1	0	0	0	0	0	1	0	0	4433	1299	45	1	4235	1	DENND4A	15	66015201	Nonsense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	23502908	66015201	36516191	155	35972										
PAQR5	54852	broad.mit.edu	37	chr15	69677202	69677202	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tacttcctggactatggtgcCgtcaacctcttcagcctggg	10	13	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:69677202C>T	uc002arz.2	+	5	744	c.366C>T	c.(364-366)GCC>GCT	p.A122A	PAQR5_uc002asa.2_Silent_p.A122A	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	122	Helical; Name=3; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						ACTATGGTGCCGTCAACCTCT	0.562													0	0	0	0.006122	0	16	19										T	69677202	C	T	69677202	2	4	120	1	0	0	0	0	0	0	0	1	11438	639	23	2		2	PAQR5	15	69677202	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3662001	69677202	32854190	156	35973										
THSD4	79875	broad.mit.edu	37	chr15	72039168	72039176	+	Splice_Site	DEL	CTGAACCAG	CTGAACCAG	-													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcactctcgctctctcattcCtgaaccagctgggacatcgg							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:72039168_72039176delCTGAACCAG	uc002atb.1	+	12	2116	c.2037_splice	c.e12-1	p.F679_splice	THSD4_uc002ate.2_Splice_Site_p.F319_splice	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4							proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TCTCTCATTCCTGAACCAGCTGGGACATC	0.584																		12	101	---	---								-	72039176	CTGAACCAG	-	72039168	8	5	120	1	0	1	0	1	0	0	1	0	15875	696	24	0		0	THSD4	15	72039168	Splice_Site	DEL	CTGAACCAG	TCGA-GV-A3QH-01A-11D-A21Z-08	2361966	72039168	30492224	157	35974										
BTBD1	53339	broad.mit.edu	37	chr15	83698894	83698894	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aatataacagatacctgattCgatcactcgtcccactgtaa	5	11	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:83698894C>T	uc002bjn.2	-	5	1252	c.1049G>A	c.(1048-1050)CGA>CAA	p.R350Q	BTBD1_uc002bjo.2_Missense_Mutation_p.R350Q	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	350						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		ATACCTGATTCGATCACTCGT	0.448													0	0	0	0.00361	0	187	388										T	83698894	C	T	83698894	3	4	120	1	0	0	0	0	1	0	0	0	1537	884	31	1	415	1	BTBD1	15	83698894	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	11659726	83698894	18832498	158	35975										
BTBD1	53339	broad.mit.edu	37	chr15	83735836	83735836	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agggcggcggcggcggccccGcggggcccggctccgcctca	19	18	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:83735836G>A	uc002bjn.2	-	1	271	c.68C>T	c.(67-69)GCG>GTG	p.A23V	BTBD1_uc002bjo.2_Missense_Mutation_p.A23V	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	23						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		cggcggccccgcggggcccgg	0.582													0	0	0	0.009096	0	4	5										A	83735836	G	A	83735836	3	1	120	1	0	0	0	0	1	0	0	0	1537	1087	38	2	1412	2	BTBD1	15	83735836	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	36942	83735836	18795556	159	35976										
MPG	4350	broad.mit.edu	37	chr16	135661	135661	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggctgtagtggcagcagcccGggtgggcgtcggccatgcag	19	11	0	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:135661G>A	uc002cfn.2	+	5	1100	c.782G>A	c.(781-783)CGG>CAG	p.R261Q	MPG_uc002cfm.2_Missense_Mutation_p.R244Q|MPG_uc002cfo.2_Missense_Mutation_p.R256Q|NPRL3_uc010uua.1_Intron|NPRL3_uc002cfp.1_Intron	NM_002434	NP_002425	P29372	3MG_HUMAN	N-methylpurine-DNA glycosylase isoform a	261					depurination|DNA dealkylation involved in DNA repair	nucleoplasm	alkylbase DNA N-glycosylase activity|damaged DNA binding|identical protein binding			ovary(1)|skin(1)	2		all_cancers(16;9.01e-08)|all_epithelial(16;7.64e-07)|Hepatocellular(780;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GCAGCAGCCCGGGTGGGCGTC	0.657								BER_DNA_glycosylases					0	0	0	0.009096	0	4	6										A	135661	G	A	135661	3	1	120	1	0	0	0	0	1	0	0	0	9724	1116	39	2	824	2	MPG	16	135661	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		135661	90219092	160	35977										
BTBD12	84464	broad.mit.edu	37	chr16	3639978	3639978	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gccccgattctccggcagcgCcccctcatcctcctgctgca	8	21	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:3639978C>A	uc002cvp.2	-	12	4288	c.3661G>T	c.(3661-3663)GCG>TCG	p.A1221S		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1221	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TCCGGCAGCGCCCCCTCATCC	0.607								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				1	0	5.35267e-07	0.007413	5.46146e-07	17	45										A	3639978	C	A	3639978	3	1	120	1	0	0	0	0	1	0	0	0	1540	739	26	4	1859	4	BTBD12	16	3639978	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3504317	3639978	86714775	161	35978										
ERCC4	2072	broad.mit.edu	37	chr16	14021928	14021928	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttttagaacagcacaaacctGaagttgtagaaatccatgtt	7	7	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:14021928G>A	uc002dce.2	+	4	637	c.628G>A	c.(628-630)GAA>AAA	p.E210K	ERCC4_uc010bva.2_Missense_Mutation_p.E210K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	210					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						GCACAAACCTGAAGTTGTAGA	0.343			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.007835	0	29	77										A	14021928	G	A	14021928	3	1	120	1	0	0	0	0	1	0	0	0	5215	1291	45	1	642	1	ERCC4	16	14021928	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	10381950	14021928	76332825	162	35979										
MKL2	57496	broad.mit.edu	37	chr16	14354763	14354764	+	Splice_Site	INS	-	-	A													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttacttcatttattttacacINSagagatctccctccccataa							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:14354763_14354764insA	uc010uza.1	+	17	2920	c.2765_splice	c.e17-2	p.E922_splice	MKL2_uc002dcg.2_Splice_Site_p.E872_splice|MKL2_uc002dcj.2_Splice_Site_p.E167_splice	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein						cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						TTATTTTACACAGAGATCTCCC	0.361																		27	81	---	---								A	14354764	-	A	14354763	8	5	120	1	0	1	1	0	0	0	1	0	9602	493	17	0		0	MKL2	16	14354763	Splice_Site	INS	-	TCGA-GV-A3QH-01A-11D-A21Z-08	332835	14354763	75999990	163	35980										
TAOK2	9344	broad.mit.edu	37	chr16	29996729	29996729	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctggctttggggcagaggcaGaaaagctggcccggcggcac	17	11	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:29996729G>A	uc002dva.1	+	14	2401	c.1618G>A	c.(1618-1620)GAA>AAA	p.E540K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.E540K|TAOK2_uc002dvc.1_Missense_Mutation_p.E540K|TAOK2_uc010bzm.1_Missense_Mutation_p.E547K|TAOK2_uc002dvd.1_Missense_Mutation_p.E367K	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	540	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GGCAGAGGCAGAAAAGCTGGC	0.672													0	0	0	0.000602	0	5	6										A	29996729	G	A	29996729	3	1	120	1	0	0	0	0	1	0	0	0	15545	943	33	1	1668	1	TAOK2	16	29996729	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	15641966	29996729	60358024	164	35981										
ZNF267	10308	broad.mit.edu	37	chr16	31927296	31927296	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttcatactggagaaaaaccaTacaaatgtaaagcatgtagc	7	7	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:31927296T>C	uc002ecs.3	+	4	1935	c.1726T>C	c.(1726-1728)TAC>CAC	p.Y576H		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	576	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AGAAAAACCATACAAATGTAA	0.383													0	0	0	0.006122	0	14	42										C	31927296	T	C	31927296	3	2	120	1	0	0	0	0	1	0	0	0	17803	1406	49	5	1740	5	ZNF267	16	31927296	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	1930567	31927296	58427457	165	35982										
MYLK3	91807	broad.mit.edu	37	chr16	46771856	46771856	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tccaggccagtcctgaggttCtcgctgggtgtctcaggagc	14	12	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46771856C>T	uc002eei.3	-	3	884	c.768G>A	c.(766-768)GAG>GAA	p.E256E	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	256					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCTGAGGTTCTCGCTGGGTG	0.647													0	0	0	0.001368	0	11	42										T	46771856	C	T	46771856	2	4	120	1	0	0	0	0	0	0	0	1	10058	912	32	1		1	MYLK3	16	46771856	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	14844560	46771856	43582897	166	35983			1	170		4	4	2126	C		5.439777e-07
MYLK3	91807	broad.mit.edu	37	chr16	46772020	46772020	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctgatggggggcagcctctCcgctgtcccctccagcacgt	12	16	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46772020C>T	uc002eei.3	-	3	720	c.604G>A	c.(604-606)GAG>AAG	p.E202K	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	202					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGCAGCCTCTCCGCTGTCCCC	0.637													0	0	0	0.00308	0	6	13										T	46772020	C	T	46772020	3	4	120	1	0	0	0	0	1	0	0	0	10058	864	30	1	1899	1	MYLK3	16	46772020	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	164	46772020	43582733	167	35984			1	170		4	4	2126	C		5.439777e-07
MYLK3	91807	broad.mit.edu	37	chr16	46773969	46773969	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gcaaatggggtcccactcacCttccccaggctccctggcat	9	17	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46773969C>T	uc002eei.3	-	2	684	c.568G>A	c.(568-570)GAG>AAG	p.E190K	MYLK3_uc010vge.1_5'UTR|MYLK3_uc002eej.1_5'Flank	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	190					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCCACTCACCTTCCCCAGGC	0.502													0	0	0	0.00333	0	12	155										T	46773969	C	T	46773969	3	4	120	1	0	0	0	0	1	0	0	0	10058	695	24	2	1939	2	MYLK3	16	46773969	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	1949	46773969	43580784	168	35985			1	170		4	4	2126	C		5.439777e-07
MYLK3	91807	broad.mit.edu	37	chr16	46773981	46773981	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ccactcaccttccccaggctCcctggcatcagactgcaccc	6	21	2	1	rs55813660		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46773981C>T	uc002eei.3	-	2	672	c.556G>A	c.(556-558)GAG>AAG	p.E186K	MYLK3_uc010vge.1_5'UTR|MYLK3_uc002eej.1_5'Flank	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	186					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCCCAGGCTCCCTGGCATCA	0.473													0	0	0	0.003954	0	12	165										T	46773981	C	T	46773981	3	4	120	1	0	0	0	0	1	0	0	0	10058	864	30	1	1951	1	MYLK3	16	46773981	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	12	46773981	43580772	169	35986			1	170		4	4	2126	C		5.439777e-07
CDH11	1009	broad.mit.edu	37	chr16	64981662	64981662	+	Nonsense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gccactgagcccctgccttcAtaaccgtagatttgaatgga	9	12	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:64981662A>C	uc002eoi.2	-	13	2669	c.2235T>G	c.(2233-2235)TAT>TAG	p.Y745*	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Nonsense_Mutation_p.Y619*	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	745	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCCTGCCTTCATAACCGTAGA	0.527			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.008871	0	16	57										C	64981662	A	C	64981662	4	2	120	1	0	0	0	0	0	1	0	0	3097	224	8	5	159	5	CDH11	16	64981662	Nonsense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	18207681	64981662	25373091	170	35987										
C16orf55	124045	broad.mit.edu	37	chr16	89735693	89735693	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cctggatgttttttcctctaGagaaacctgatgtaaagcaa	8	8	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:89735693G>C	uc002fnw.1	+	3	209	c.209_splice	c.e3-1	p.E70_splice	C16orf55_uc010vpk.1_Splice_Site_p.E71_splice|C16orf55_uc002fny.1_Splice_Site	NM_153025	NP_694570	Q96N06	CP055_HUMAN	hypothetical protein LOC124045												0		all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		TTTTCCTCTAGAGAAACCTGA	0.458													0	0	0	0.004482	0	8	32										C	89735693	G	C	89735693	5	2	120	1	0	0	0	0	0	0	1	0	1820	956	33	1	218	1	C16orf55	16	89735693	Splice_Site	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	24754031	89735693	619060	171	35988										
TP53	7157	broad.mit.edu	37	chr17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgatggtgaggatgggcctcCggttcatgccgcccatgcag	15	11	1	2	rs11540652		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	54	16										T	7577538	C	T	7577538	3	4	120	1	0	0	0	0	1	0	0	0	16378	652	23	2	547	2	TP53	17	7577538	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		7577538	73617672	172	35989										
MYH10	4628	broad.mit.edu	37	chr17	8379127	8379127	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tggcttcctgcaactttactCtgactggggtggctgcgtct	12	11	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:8379127C>G	uc002gll.2	-	41	6022	c.5926G>C	c.(5926-5928)GAG>CAG	p.E1976Q	MYH10_uc002glm.2_Missense_Mutation_p.E2007Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1985Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1976	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CAACTTTACTCTGACTGGGGT	0.562													0	0	0	0.00361	0	151	67										G	8379127	C	G	8379127	3	3	120	1	0	0	0	0	1	0	0	0	10030	922	32	1	8	1	MYH10	17	8379127	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	801589	8379127	72816083	173	35990										
SUZ12	23512	broad.mit.edu	37	chr17	30323833	30323833	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ccagcaaattgaagagttttCtgatgttaatgaaggagaga	11	4	1	5			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:30323833C>G	uc002hgs.2	+	15	2033	c.1811C>G	c.(1810-1812)TCT>TGT	p.S604C	SUZ12_uc002hgt.2_Missense_Mutation_p.S581C	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	604	VEFS-box.				negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				GAAGAGTTTTCTGATGTTAAT	0.294			T	JAZF1	endometrial stromal tumours								0	0	0	0.00361	0	38	32										G	30323833	C	G	30323833	3	3	120	1	0	0	0	0	1	0	0	0	15413	913	32	1	1869	1	SUZ12	17	30323833	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	21944706	30323833	50871377	174	35991										
GAS2L2	246176	broad.mit.edu	37	chr17	34077315	34077315	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttcttgcgcagcaccaagtcCtccgtctcgaacatcagcac	7	16	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:34077315C>T	uc002hjv.1	-	2	436	c.408G>A	c.(406-408)GAG>GAA	p.E136E		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	136	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCACCAAGTCCTCCGTCTCGA	0.662													0	0	0	0.00632	0	27	260										T	34077315	C	T	34077315	2	4	120	1	0	0	0	0	0	0	0	1	6247	680	24	2		2	GAS2L2	17	34077315	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3753482	34077315	47117895	175	35992										
GAS2L2	246176	broad.mit.edu	37	chr17	34079717	34079717	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	acctgcaggaagttggctgcGtcgatgtccagcccatagag	13	11	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:34079717G>T	uc002hjv.1	-	1	181	c.153C>A	c.(151-153)GAC>GAA	p.D51E		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	51	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTTGGCTGCGTCGATGTCCA	0.607													1	0	4.09166e-32	0.00361	4.44592e-32	60	87										T	34079717	G	T	34079717	3	4	120	1	0	0	0	0	1	0	0	0	6247	1136	40	4	2513	4	GAS2L2	17	34079717	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	2402	34079717	47115493	176	35993										
ACACA	31	broad.mit.edu	37	chr17	35615271	35615271	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	catacggatatccttgattcTatatagaggaatccccatgg	8	9	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:35615271T>G	uc002hnm.2	-	13	1605	c.1414A>C	c.(1414-1416)AGA>CGA	p.R472R	ACACA_uc002hnk.2_Silent_p.R394R|ACACA_uc002hnl.2_Silent_p.R414R|ACACA_uc002hnn.2_Silent_p.R472R|ACACA_uc002hno.2_Silent_p.R509R|ACACA_uc010cuz.2_Silent_p.R472R	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	472	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TCCTTGATTCTATATAGAGGA	0.403													0	0	0	0.009535	0	23	110										G	35615271	T	G	35615271	2	3	120	1	0	0	0	0	0	0	0	1	106	1530	53	5		5	ACACA	17	35615271	Silent	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	1535554	35615271	45579939	177	35994										
ERBB2	2064	broad.mit.edu	37	chr17	37868200	37868200	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gacaactacctttctacggaCgtgggatcctgcaccctcgt	9	14	1	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:37868200C>T	uc002hso.2	+	8	1159	c.921C>T	c.(919-921)GAC>GAT	p.D307D	ERBB2_uc002hsm.2_Silent_p.D277D|ERBB2_uc010cwa.2_Silent_p.D292D|ERBB2_uc002hsp.2_Silent_p.D110D|ERBB2_uc010cwb.2_Silent_p.D307D|ERBB2_uc010wek.1_Silent_p.D31D|ERBB2_uc002hsl.2_Silent_p.D277D|ERBB2_uc002hsn.1_Silent_p.D307D	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	307	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TTTCTACGGACGTGGGATCCT	0.577		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.010729	0	9	949										T	37868200	C	T	37868200	2	4	120	1	0	0	0	0	0	0	0	1	5206	535	19	2		2	ERBB2	17	37868200	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	2252929	37868200	43327010	178	35995										
TUBG2	27175	broad.mit.edu	37	chr17	40817733	40817733	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggccagcaccaccaccctgcGctaccccggctacatgaaca	8	19	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:40817733G>A	uc010wgr.1	+	8	987	c.731G>A	c.(730-732)CGC>CAC	p.R244H	TUBG2_uc002iaq.2_Missense_Mutation_p.R86H|TUBG2_uc002iar.2_Missense_Mutation_p.R91H|TUBG2_uc002ias.2_Missense_Mutation_p.R86H|TUBG2_uc002iap.2_Missense_Mutation_p.R91H	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	244					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		ACCACCCTGCGCTACCCCGGC	0.637													0	0	0	0.00361	0	78	162										A	40817733	G	A	40817733	3	1	120	1	0	0	0	0	1	0	0	0	16762	1087	38	2	761	2	TUBG2	17	40817733	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	2949533	40817733	40377477	179	35996										
VAT1	10493	broad.mit.edu	37	chr17	41168155	41168155	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctgcatctgtttcatggcatCagccacctggggaggaagga	13	10	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:41168155C>T	uc002icm.1	-	6	1225	c.1105G>A	c.(1105-1107)GAT>AAT	p.D369N	VAT1_uc010cyw.1_Missense_Mutation_p.D235N|VAT1_uc010whk.1_Missense_Mutation_p.D301N	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	369						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TTCATGGCATCAGCCACCTGG	0.567													0	0	0	0.008291	0	9	424										T	41168155	C	T	41168155	3	4	120	1	0	0	0	0	1	0	0	0	17126	826	29	1	80	1	VAT1	17	41168155	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	350422	41168155	40027055	180	35997										
BCAS3	54828	broad.mit.edu	37	chr17	59152341	59152341	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtcttacgacagtttagcttCtgaccatagtggacaggaag	11	8	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:59152341C>T	uc002iyv.3	+	21	2244	c.2135C>T	c.(2134-2136)TCT>TTT	p.S712F	BCAS3_uc002iyu.3_Missense_Mutation_p.S697F|BCAS3_uc002iyw.3_Missense_Mutation_p.S693F|BCAS3_uc002iyy.3_Missense_Mutation_p.S468F|BCAS3_uc002iyz.3_Missense_Mutation_p.S266F|BCAS3_uc002iza.3_Missense_Mutation_p.S251F	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	712						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGTTTAGCTTCTGACCATAGT	0.378													0	0	0	0.00361	0	64	112										T	59152341	C	T	59152341	3	4	120	1	0	0	0	0	1	0	0	0	1352	913	32	1	2213	1	BCAS3	17	59152341	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	17984186	59152341	22042869	181	35998										
ABCA8	10351	broad.mit.edu	37	chr17	66899519	66899519	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gcgcagatttgctgtcgccaGagagccacaccacctattgt	10	13	0	2	rs144614574		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:66899519G>A	uc002jhp.2	-	18	2579	c.2400C>T	c.(2398-2400)CTC>CTT	p.L800L	ABCA8_uc002jhq.2_Silent_p.L840L|ABCA8_uc010wqq.1_Silent_p.L840L|ABCA8_uc010wqr.1_Silent_p.L779L|ABCA8_uc002jhr.2_Silent_p.L840L	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	800						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GCTGTCGCCAGAGAGCCACAC	0.433													0	0	0	0.00361	0	69	133										A	66899519	G	A	66899519	2	1	120	1	0	0	0	0	0	0	0	1	38	929	33	1		1	ABCA8	17	66899519	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	7747178	66899519	14295691	182	35999										
DSG2	1829	broad.mit.edu	37	chr18	29125912	29125912	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ataaggaaattgagcagagaCaaaaacctgccacagaaaca	8	8	0	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:29125912C>A	uc002kwu.3	+	15	2751	c.2563C>A	c.(2563-2565)CAA>AAA	p.Q855K	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	855	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TGAGCAGAGACAAAAACCTGC	0.388													1	0	0.000566183	0.00499	0.000573032	4	95										A	29125912	C	A	29125912	3	1	120	1	0	0	0	0	1	0	0	0	4777	479	17	4	2621	4	DSG2	18	29125912	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		29125912	48951336	183	36000										
C18orf34	374864	broad.mit.edu	37	chr18	30804901	30804901	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	taaatggaatatagttttttCtgccagcaaagattttaaat	6	4	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:30804901C>G	uc002kxn.2	-	16	1799	c.1657_splice	c.e16-1	p.K553_splice	C18orf34_uc010dme.1_Splice_Site_p.K67_splice|C18orf34_uc010xbr.1_Splice_Site_p.K553_splice|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Splice_Site_p.K553_splice|C18orf34_uc002kxp.2_Splice_Site_p.K553_splice	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1											ovary(1)	1						ATAGTTTTTTCTGCCAGCAAA	0.328													0	0	0	0.004007	0	13	50										G	30804901	C	G	30804901	5	3	120	1	0	0	0	0	0	0	1	0	1902	927	32	1	975	1	C18orf34	18	30804901	Splice_Site	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	1678989	30804901	47272347	184	36001										
SEC11C	90701	broad.mit.edu	37	chr18	56816747	56816747	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcctctttttcattccagctCtattaccaggttttaaactt	3	11	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:56816747C>T	uc002lht.2	+	2	146	c.90C>T	c.(88-90)CTC>CTT	p.L30L	SEC11C_uc010dpo.1_Silent_p.L30L|SEC11C_uc010xej.1_Silent_p.L30L	NM_033280	NP_150596	Q9BY50	SC11C_HUMAN	SEC11-like 3	30	Helical; Signal-anchor for type II membrane protein; (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity				0		Colorectal(73;0.175)				CATTCCAGCTCTATTACCAGG	0.448													0	0	0	0.00361	0	59	57										T	56816747	C	T	56816747	2	4	120	1	0	0	0	0	0	0	0	1	13979	900	32	1		1	SEC11C	18	56816747	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	26011846	56816747	21260501	185	36002										
ZCCHC2	54877	broad.mit.edu	37	chr18	60241918	60241918	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gttgctaccacggaccccatCacaaaatctgcatcccaagt	6	15	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:60241918C>T	uc002lip.3	+	13	2604	c.2604C>T	c.(2602-2604)ATC>ATT	p.I868I	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Silent_p.I338I	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	868					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						CGGACCCCATCACAAAATCTG	0.507													0	0	0	0.004878	0	33	117										T	60241918	C	T	60241918	2	4	120	1	0	0	0	0	0	0	0	1	17584	816	29	1		1	ZCCHC2	18	60241918	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3425171	60241918	17835330	186	36003										
VPS4B	9525	broad.mit.edu	37	chr18	61058250	61058250	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctgtaaacttctttaatttCaacaagtcatgttcattgac	4	8	5	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:61058250C>G	uc002lix.2	-	11	1553	c.1293G>C	c.(1291-1293)TTG>TTC	p.L431F		NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	431					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						TCTTTAATTTCAACAAGTCAT	0.353													0	0	0	0.012213	0	24	39										G	61058250	C	G	61058250	3	3	120	1	0	0	0	0	1	0	0	0	17210	825	29	1	45	1	VPS4B	18	61058250	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	816332	61058250	17018998	187	36004										
C19orf26	255057	broad.mit.edu	37	chr19	1231042	1231042	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctgggccgcctaggggggggCgaaggggggcaagggcccac	22	11	0	0	rs75463186		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:1231042C>A	uc002lrm.2	-	9	1469	c.1194G>T	c.(1192-1194)TCG>TCT	p.S398S		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGGGGGGGGCGAAGGGGGGC	0.716										HNSCC(14;0.022)			1	0	2.0095e-06	0.001984	2.04204e-06	6	28										A	1231042	C	A	1231042	2	1	120	1	0	0	0	0	0	0	0	1	1916	755	27	4		4	C19orf26	19	1231042	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		1231042	57897941	188	36005										
MUC16	94025	broad.mit.edu	37	chr19	9071151	9071151	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aggattgtgatttatgtccaGacccggaagtccctacattg	10	9	0	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:9071151G>C	uc002mkp.2	-	3	16499	c.16295C>G	c.(16294-16296)TCT>TGT	p.S5432C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5434	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTATGTCCAGACCCGGAAGT	0.522													0	0	0	0.001984	0	6	369										C	9071151	G	C	9071151	3	2	120	1	0	0	0	0	1	0	0	0	9973	942	33	1	27556	1	MUC16	19	9071151	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	7840109	9071151	50057832	189	36006										
MUC16	94025	broad.mit.edu	37	chr19	9076312	9076312	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctttgtactagcatgatctgTagaaaccattgaaacaggca	8	8	1	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:9076312T>C	uc002mkp.2	-	3	11338	c.11134A>G	c.(11134-11136)ACA>GCA	p.T3712A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3713	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATGATCTGTAGAAACCATT	0.458													0	0	0	0.004878	0	32	123										C	9076312	T	C	9076312	3	2	120	1	0	0	0	0	1	0	0	0	9973	1638	57	5	32717	5	MUC16	19	9076312	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	5161	9076312	50052671	190	36007										
CARM1	10498	broad.mit.edu	37	chr19	11031771	11031771	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cagtgttattgccagtggctCcagcgtgggccacaacaacc	11	13	0	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:11031771C>G	uc002mpz.2	+	14	1709	c.1583C>G	c.(1582-1584)TCC>TGC	p.S528C	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Missense_Mutation_p.S311C	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	528	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						GCCAGTGGCTCCAGCGTGGGC	0.662													0	0	0	0.003163	0	11	44										G	11031771	C	G	11031771	3	3	120	1	0	0	0	0	1	0	0	0	2655	855	30	1	1637	1	CARM1	19	11031771	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	1955459	11031771	48097212	191	36008										
FBXW9	84261	broad.mit.edu	37	chr19	12800930	12800931	+	In_Frame_Ins	INS	-	-	GAA													0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cagggctgggccggcttcatINSgggtgatgggccggtgagga							TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:12800930_12800931insGAA	uc010dyx.2	-	6	937_938	c.937_938insTTC	c.(937-939)CAT>CTTCAT	p.312_313insL	FBXW9_uc010xmp.1_Intron|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Intron|FBXW9_uc002mun.1_Intron	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	322_323							protein binding			ovary(1)	1						GCCGGCTTCATGGGTGATGGGC	0.634																		23	109	---	---								GAA	12800931	-	GAA	12800930	7	5	120	1	0	1	1	0	0	0	0	0	5771	1479	51	0		0	FBXW9	19	12800930	In_Frame_Ins	INS	-	TCGA-GV-A3QH-01A-11D-A21Z-08	1769159	12800930	46328053	192	36009										
BEST2	54831	broad.mit.edu	37	chr19	12864153	12864153	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	agtatgccagcctcatccctGtctccttcgtgcttggtgcg	10	14	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:12864153G>C	uc002mux.2	+	2	232	c.232G>C	c.(232-234)GTC>CTC	p.V78L		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	78	Helical; (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						CCTCATCCCTGTCTCCTTCGT	0.552													0	0	0	0.00278	0	20	124										C	12864153	G	C	12864153	3	2	120	1	0	0	0	0	1	0	0	0	1405	1377	48	4	238	4	BEST2	19	12864153	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	63223	12864153	46264830	193	36010										
ZNF257	113835	broad.mit.edu	37	chr19	22271633	22271633	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	accggtcttcacaccttactCaacataagataattcatact	3	12	4	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:22271633C>G	uc010ecx.2	+	4	1250	c.1081C>G	c.(1081-1083)CAA>GAA	p.Q361E	ZNF257_uc010ecy.2_Missense_Mutation_p.Q329E	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	361	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACACCTTACTCAACATAAGAT	0.398													0	0	0	0.006122	0	13	37										G	22271633	C	G	22271633	3	3	120	1	0	0	0	0	1	0	0	0	17797	827	29	1	1095	1	ZNF257	19	22271633	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	9407480	22271633	36857350	194	36011										
SIPA1L3	23094	broad.mit.edu	37	chr19	38655151	38655151	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tactcaagtcattccagcagCaacaccctctccagcaacgc	5	17	3	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:38655151C>G	uc002ohk.2	+	15	4322	c.3813C>G	c.(3811-3813)AGC>AGG	p.S1271R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1271					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATTCCAGCAGCAACACCCTCT	0.622													0	0	0	0.00361	0	72	139										G	38655151	C	G	38655151	3	3	120	1	0	0	0	0	1	0	0	0	14331	709	25	4	3863	4	SIPA1L3	19	38655151	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	16383518	38655151	20473832	195	36012										
HNRNPUL1	11100	broad.mit.edu	37	chr19	41782119	41782119	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cggagtagtggctatccgctCacaattgagggctttgcata	12	9	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:41782119C>T	uc002oqb.3	+	5	991	c.702C>T	c.(700-702)CTC>CTT	p.L234L	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.L134L|HNRNPUL1_uc002oqa.3_Silent_p.L134L|HNRNPUL1_uc010ehm.2_Silent_p.L234L|HNRNPUL1_uc002oqc.3_Silent_p.L191L|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.L134L|HNRNPUL1_uc010ehn.2_Silent_p.L134L|HNRNPUL1_uc010eho.2_Silent_p.L134L|HNRNPUL1_uc010xvy.1_Silent_p.L134L|HNRNPUL1_uc010ehp.2_Silent_p.L90L|HNRNPUL1_uc010ehl.1_Silent_p.L134L	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	234	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						GCTATCCGCTCACAATTGAGG	0.512													0	0	0	0.00361	0	101	138										T	41782119	C	T	41782119	2	4	120	1	0	0	0	0	0	0	0	1	7274	813	29	1		1	HNRNPUL1	19	41782119	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	3126968	41782119	17346864	196	36013										
PPP5C	5536	broad.mit.edu	37	chr19	46888119	46888119	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgtagaagtgatcctcacccTtttcggcttcaagctcctgt	8	12	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:46888119T>C	uc002pem.2	+	7	917	c.857T>C	c.(856-858)CTT>CCT	p.L286P	PPP5C_uc010xya.1_Missense_Mutation_p.L153P|PPP5C_uc002pen.2_Missense_Mutation_p.L264P|PPP5C_uc010xyb.1_Missense_Mutation_p.L144P	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	286	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		ATCCTCACCCTTTTCGGCTTC	0.527													0	0	0	0.000602	0	3	139										C	46888119	T	C	46888119	3	2	120	1	0	0	0	0	1	0	0	0	12406	1609	56	5	883	5	PPP5C	19	46888119	Missense_Mutation	SNP	T	TCGA-GV-A3QH-01A-11D-A21Z-08	5106000	46888119	12240864	197	36014										
ZNF83	55769	broad.mit.edu	37	chr19	53116283	53116283	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cacattaattacatgtgttaGatttctttccggcatgaaat	6	7	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:53116283G>C	uc002pzu.3	-	2	2779	c.1535C>G	c.(1534-1536)TCT>TGT	p.S512C	ZNF83_uc002pzv.3_Missense_Mutation_p.S512C|ZNF83_uc010eps.2_Missense_Mutation_p.S484C|ZNF83_uc010ept.2_Missense_Mutation_p.S512C|ZNF83_uc010epu.2_Missense_Mutation_p.S512C|ZNF83_uc010epv.2_Missense_Mutation_p.S512C|ZNF83_uc010epw.2_Missense_Mutation_p.S512C|ZNF83_uc010epx.2_Missense_Mutation_p.S484C|ZNF83_uc010epy.2_Missense_Mutation_p.S512C|ZNF83_uc010epz.2_Missense_Mutation_p.S484C	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	512						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		ACATGTGTTAGATTTCTTTCC	0.348													0	0	0	0.00361	0	44	75										C	53116283	G	C	53116283	3	2	120	1	0	0	0	0	1	0	0	0	18180	942	33	1	19	1	ZNF83	19	53116283	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	6228164	53116283	6012700	198	36015										
ZNF71	58491	broad.mit.edu	37	chr19	57133450	57133450	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gtgcaccagcgcacgcacacCggggagaagccgtacgtgtg	15	13	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:57133450C>G	uc002qnm.3	+	3	1033	c.795C>G	c.(793-795)ACC>ACG	p.T265T		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	265						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GCACGCACACCGGGGAGAAGC	0.672													0	0	0	0.010504	0	20	94										G	57133450	C	G	57133450	2	3	120	1	0	0	0	0	0	0	0	1	18111	639	23	4		4	ZNF71	19	57133450	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	4017167	57133450	1995533	199	36016										
RALGAPA2	57186	broad.mit.edu	37	chr20	20506951	20506951	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctgaagcttctcccagtagGaaaccagcaactgaaggaca	9	11	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:20506951G>C	uc002wrz.2	-	28	3781	c.3638C>G	c.(3637-3639)TCC>TGC	p.S1213C	RALGAPA2_uc010gcx.2_Missense_Mutation_p.S917C|RALGAPA2_uc010zsg.1_Missense_Mutation_p.S661C|RALGAPA2_uc002wsa.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1213					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CTCCCAGTAGGAAACCAGCAA	0.408													0	0	0	0.001368	0	9	31										C	20506951	G	C	20506951	3	2	120	1	0	0	0	0	1	0	0	0	13014	1174	41	1	2031	1	RALGAPA2	20	20506951	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		20506951	42518569	200	36017										
ZNF337	26152	broad.mit.edu	37	chr20	25656896	25656896	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atctgtaaggcttctctcctGagtgtattctcttgtgcaca	8	10	3	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:25656896G>C	uc002wva.2	-	4	1550	c.1028C>G	c.(1027-1029)TCA>TGA	p.S343*	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Nonsense_Mutation_p.S311*|ZNF337_uc002wvb.2_Nonsense_Mutation_p.S343*|ZNF337_uc002wvc.2_Nonsense_Mutation_p.S343*	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTCTCCTGAGTGTATTCT	0.498													0	0	0	0.003755	0	35	53										C	25656896	G	C	25656896	4	2	120	1	0	0	0	0	0	1	0	0	17850	1294	45	1	1231	1	ZNF337	20	25656896	Nonsense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	5149945	25656896	37368624	201	36018										
NCOA6	23054	broad.mit.edu	37	chr20	33364214	33364214	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aatgtcacacgcacgctgttCcagggctccaccttctgtac	8	15	2	0			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:33364214C>T	uc002xav.2	-	5	2844	c.273G>A	c.(271-273)TGG>TGA	p.W91*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.W91*|NCOA6_uc010gew.1_Nonsense_Mutation_p.W91*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	91	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GCACGCTGTTCCAGGGCTCCA	0.473													0	0	0	0.013114	0	39	64										T	33364214	C	T	33364214	4	4	120	1	0	0	0	0	0	1	0	0	10233	856	30	1	5966	1	NCOA6	20	33364214	Nonsense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	7707318	33364214	29661306	202	36019										
PHF20	51230	broad.mit.edu	37	chr20	34526618	34526618	+	Splice_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcctctttgtcctctcaacaGaagccgggagcatcctgatc	8	14	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:34526618G>T	uc002xek.1	+	16	2412	c.2301_splice	c.e16-1	p.Q767_splice		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20						regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCTCTCAACAGAAGCCGGGAG	0.542													1	0	4.89347e-83	0.00361	5.38711e-83	148	247										T	34526618	G	T	34526618	5	4	120	1	0	0	0	0	0	0	1	0	11831	956	33	3	2358	3	PHF20	20	34526618	Splice_Site	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1162404	34526618	28498902	203	36020										
PHF20	51230	broad.mit.edu	37	chr20	34526935	34526935	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	atgcggtcaaccccctccatGagaacggcgatgattccctt	9	14	1	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:34526935G>A	uc002xek.1	+	16	2728	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCCCCTCCATGAGAACGGCGA	0.632													0	0	0	0.006999	0	38	59										A	34526935	G	A	34526935	3	1	120	1	0	0	0	0	1	0	0	0	11831	1291	45	1	2675	1	PHF20	20	34526935	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	317	34526935	28498585	204	36021										
TRAPPC10	7109	broad.mit.edu	37	chr21	45479022	45479022	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ttcgagatgctgcagcagttCgaggacgccctggtgcagta	14	10	0	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr21:45479022C>T	uc002zea.2	+	6	886	c.717C>T	c.(715-717)TTC>TTT	p.F239F	TRAPPC10_uc010gpo.2_5'UTR|TRAPPC10_uc002zdz.2_Silent_p.F239F	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	239					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TGCAGCAGTTCGAGGACGCCC	0.473													0	0	0	0.008361	0	22	51										T	45479022	C	T	45479022	2	4	120	1	0	0	0	0	0	0	0	1	16454	883	31	1		1	TRAPPC10	21	45479022	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		45479022	2650873	205	36022										
PCNT	5116	broad.mit.edu	37	chr21	47768968	47768968	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ctgaaaaagatttatgtttaGaaaatctacgcaaagaactg	7	5	1	4			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr21:47768968G>C	uc002zji.3	+	7	1182	c.1075G>C	c.(1075-1077)GAA>CAA	p.E359Q	PCNT_uc002zjj.2_Missense_Mutation_p.E241Q|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	359	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TTTATGTTTAGAAAATCTACG	0.323													0	0	0	0.00361	0	41	112										C	47768968	G	C	47768968	3	2	120	1	0	0	0	0	1	0	0	0	11590	943	33	1	1101	1	PCNT	21	47768968	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	2289946	47768968	360927	206	36023										
CECR2	27443	broad.mit.edu	37	chr22	17976513	17976513	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gaagggaagcccaaccctctGagggaagccagtttccagga	13	11	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:17976513G>C	uc010gqw.1	+	2	300	c.174G>C	c.(172-174)CTG>CTC	p.L58L	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	100					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CCAACCCTCTGAGGGAAGCCA	0.567													0	0	0	0.010504	0	20	93										C	17976513	G	C	17976513	2	2	120	1	0	0	0	0	0	0	0	1	3206	1277	45	1		1	CECR2	22	17976513	Silent	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		17976513	33328053	207	36024										
TRIOBP	11078	broad.mit.edu	37	chr22	38119384	38119384	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tcaggctgcctctacacgtgAaatccccagagcctcctctc	7	17	3	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:38119384A>C	uc003atr.2	+	7	1092	c.821A>C	c.(820-822)GAA>GCA	p.E274A	TRIOBP_uc003atu.2_Missense_Mutation_p.E102A|TRIOBP_uc003atq.1_Missense_Mutation_p.E274A|TRIOBP_uc003ats.1_Missense_Mutation_p.E102A	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	274					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TCTACACGTGAAATCCCCAGA	0.592													0	0	0	0.012319	0	19	75										C	38119384	A	C	38119384	3	2	120	1	0	0	0	0	1	0	0	0	16550	246	9	5	839	5	TRIOBP	22	38119384	Missense_Mutation	SNP	A	TCGA-GV-A3QH-01A-11D-A21Z-08	20142871	38119384	13185182	208	36025										
POLDIP3	84271	broad.mit.edu	37	chr22	42999052	42999052	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gcatctgagaggccaatcttCtgccgggcatcaaatctctg	10	12	5	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:42999052C>G	uc003bcu.2	-	2	273	c.174G>C	c.(172-174)CAG>CAC	p.Q58H	POLDIP3_uc011app.1_5'UTR|POLDIP3_uc003bcv.2_Missense_Mutation_p.Q58H|POLDIP3_uc011apq.1_Missense_Mutation_p.Q58H|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Missense_Mutation_p.Q58H	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	58					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						GGCCAATCTTCTGCCGGGCAT	0.557													0	0	0	0.00361	0	49	96										G	42999052	C	G	42999052	3	3	120	1	0	0	0	0	1	0	0	0	12195	912	32	1	1123	1	POLDIP3	22	42999052	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	4879668	42999052	8305514	209	36026										
PARVB	29780	broad.mit.edu	37	chr22	44532339	44532339	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tgtttattttggggttttcaGaaacgggaaggcctgctgca	13	6	1	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:44532339G>A	uc003ben.2	+	7	686	c.634_splice	c.e7-1	p.K212_splice	PARVB_uc003bem.2_Splice_Site_p.K245_splice|PARVB_uc010gzn.2_Splice_Site_p.K160_splice|PARVB_uc003beo.2_Splice_Site_p.K175_splice	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b						cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				GGGGTTTTCAGAAACGGGAAG	0.542													0	0	0	0.005443	0	25	69										A	44532339	G	A	44532339	5	1	120	1	0	0	0	0	0	0	1	0	11469	956	33	1	878	1	PARVB	22	44532339	Splice_Site	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	1533287	44532339	6772227	210	36027										
HDAC10	83933	broad.mit.edu	37	chr22	50686355	50686355	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctcctccctcagggctgacGcttcctgttggatgacgtca	10	14	3	2	rs139748706		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:50686355G>A	uc003bkg.2	-	13	1674	c.1301C>T	c.(1300-1302)GCG>GTG	p.A434V	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.A160V|HDAC10_uc003bkf.2_Missense_Mutation_p.A160V|HDAC10_uc010hav.2_Missense_Mutation_p.A414V|HDAC10_uc003bkh.2_Missense_Mutation_p.A227V|HDAC10_uc003bki.2_Missense_Mutation_p.A384V|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.A68V	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	434					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGGCTGACGCTTCCTGTTG	0.652													0	0	0	0.006122	0	17	32										A	50686355	G	A	50686355	3	1	120	1	0	0	0	0	1	0	0	0	7005	1087	38	2	740	2	HDAC10	22	50686355	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	6154016	50686355	618211	211	36028										
WWC3	55841	broad.mit.edu	37	chrX	10093067	10093067	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	cgtgtctggtttcctaggcgCgacagtggcagcgagtgtct	15	10	2	0	rs11544574	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:10093067C>T	uc004csx.3	+	14	2028	c.1830C>T	c.(1828-1830)CGC>CGT	p.R610R	WWC3_uc010nds.2_Silent_p.R274R|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	610										ovary(4)	4						TTCCTAGGCGCGACAGTGGCA	0.607													0	0	0	0.00245	0	14	27										T	10093067	C	T	10093067	2	4	120	1	0	0	0	0	0	0	0	1	17410	755	27	2		2	WWC3	23	10093067	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08		10093067	145177493	212	36029										
BMX	660	broad.mit.edu	37	chrX	15526533	15526533	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aaaagatcacagcaaaagaaGaaaatgtcaccaaataatta	5	6	2	3			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:15526533G>C	uc004cww.2	+	2	245	c.57G>C	c.(55-57)AAG>AAC	p.K19N	BMX_uc004cwx.3_Missense_Mutation_p.K19N|BMX_uc004cwy.3_Missense_Mutation_p.K19N	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	19	PH.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AGCAAAAGAAGAAAATGTCAC	0.294													0	0	0	0.00361	0	47	8										C	15526533	G	C	15526533	3	2	120	1	0	0	0	0	1	0	0	0	1473	933	33	1	59	1	BMX	23	15526533	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	5433466	15526533	139744027	213	36030										
KDM6A	7403	broad.mit.edu	37	chrX	44969327	44969327	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctcttgtataaaacaggtgGaggtttttgatctgcttttt	9	5	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:44969327G>A	uc004dge.3	+	28	4384	c.4009G>A	c.(4009-4011)GAG>AAG	p.E1337K	KDM6A_uc011mkz.1_Missense_Mutation_p.E1389K|KDM6A_uc011mla.1_Missense_Mutation_p.E1292K|KDM6A_uc011mlb.1_Missense_Mutation_p.E1344K|KDM6A_uc011mlc.1_Missense_Mutation_p.E1041K|KDM6A_uc011mld.1_Missense_Mutation_p.E976K	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1337					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAACAGGTGGAGGTTTTTGA	0.348			D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.004289	0	32	11										A	44969327	G	A	44969327	3	1	120	1	0	0	0	0	1	0	0	0	8137	1175	41	1	4119	1	KDM6A	23	44969327	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08	29442794	44969327	110301233	214	36031										
AFF2	2334	broad.mit.edu	37	chrX	148072790	148072790	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	gggcctctgacccagcacagCagcatgaccaatcttgtccg	10	15	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:148072790C>A	uc004fcp.2	+	21	4343	c.3864C>A	c.(3862-3864)AGC>AGA	p.S1288R	AFF2_uc004fcq.2_Missense_Mutation_p.S1278R|AFF2_uc004fcr.2_Missense_Mutation_p.S1249R|AFF2_uc011mxb.1_Missense_Mutation_p.S1253R|AFF2_uc004fcs.2_Missense_Mutation_p.S1253R|AFF2_uc011mxc.1_Missense_Mutation_p.S929R	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1288					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGCACAGCAGCATGACCA	0.493													1	0	1.41595e-48	0.00361	1.54523e-48	55	97										A	148072790	C	A	148072790	3	1	120	1	0	0	0	0	1	0	0	0	357	709	25	4	4001	4	AFF2	23	148072790	Missense_Mutation	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	103103463	148072790	7197770	215	36032										
ATP2B3	492	broad.mit.edu	37	chrX	152815032	152815032	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	aacgccacagccatctgctcCgacaagacgggcacgctcac	9	17	2	1			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:152815032C>T	uc004fht.1	+	9	1542	c.1416C>T	c.(1414-1416)TCC>TCT	p.S472S	ATP2B3_uc004fhs.1_Silent_p.S472S	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	472	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCATCTGCTCCGACAAGACGG	0.607													0	0	0	0.00361	0	95	17										T	152815032	C	T	152815032	2	4	120	1	0	0	0	0	0	0	0	1	1141	639	23	2		2	ATP2B3	23	152815032	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	4742242	152815032	2455528	216	36033										
UTY	7404	broad.mit.edu	37	chrY	15435627	15435627	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	tctaccaaagttttggtagaGaaaagtccaagatctttaaa	7	6	2	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrY:15435627G>C	uc004fsx.1	-	19	3798	c.2793C>G	c.(2791-2793)TTC>TTG	p.F931L	UTY_uc004fsw.1_Missense_Mutation_p.F594L|UTY_uc010nwx.1_5'UTR|UTY_uc004fsy.2_Missense_Mutation_p.F931L|UTY_uc004fsz.2_Missense_Mutation_p.F931L	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	931					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TTTTGGTAGAGAAAAGTCCAA	0.318													0	0	0	0.008871	0	18	3										C	15435627	G	C	15435627	3	2	120	1	0	0	0	0	1	0	0	0	17104	933	33	1	1553	1	UTY	24	15435627	Missense_Mutation	SNP	G	TCGA-GV-A3QH-01A-11D-A21Z-08		15435627	43937939	217	36034										
UTY	7404	broad.mit.edu	37	chrY	15466934	15466934	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.410138248847926	89	5.51247557209935e-30	3.69258000566412	5.45524240654206	2.57564541500879	0.0821744359915376	0.201559937337734	65	ggctcttctgtgctgctgttCaggtctgtatgattatgagg	13	7	4	2			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrY:15466934C>T	uc004fsx.1	-	15	2724	c.1719G>A	c.(1717-1719)CTG>CTA	p.L573L	UTY_uc004fsw.1_Silent_p.L236L|UTY_uc010nwx.1_5'UTR|UTY_uc004fsy.2_Silent_p.L573L|UTY_uc004fsz.2_Silent_p.L573L	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	573					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGCTGCTGTTCAGGTCTGTAT	0.408													0	0	0	0.00499	0	13	8										T	15466934	C	T	15466934	2	4	120	1	0	0	0	0	0	0	0	1	17104	813	29	1		1	UTY	24	15466934	Silent	SNP	C	TCGA-GV-A3QH-01A-11D-A21Z-08	31307	15466934	43906632	218	36035										
VWA1	64856	broad.mit.edu	37	chr1	1374720	1374720	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcctgaggccccagatcctGcgggtgcgcacgcggcccgg	15	17	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:1374720G>T	uc001afs.2	+	3	1111	c.891G>T	c.(889-891)CTG>CTT	p.L297L	VWA1_uc001afr.2_Silent_p.L85L	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	297	Fibronectin type-III 1.					basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CCCAGATCCTGCGGGTGCGCA	0.766													1	0	0.004672	0.004672	0.00475046	3	0										T	1374720	G	T	1374720	2	4	121	1	0	0	0	0	0	0	0	1	17235	1306	46	4		4	VWA1	1	1374720	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		1374720	247875901	1	36036										
CLCNKA	1187	broad.mit.edu	37	chr1	16353844	16353844	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggtcatgtcttcccacttctCtgtccgggattactggaggg	12	11	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:16353844C>A	uc001axu.2	+	8	775	c.695C>A	c.(694-696)TCT>TAT	p.S232Y	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.S232Y|CLCNKA_uc010obw.1_Missense_Mutation_p.S189Y|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_5'Flank|CLCNKA_uc010oby.1_5'Flank	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	232					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	TCCCACTTCTCTGTCCGGGAT	0.647													1	0	3.00167e-28	0.00361	3.47672e-28	57	4										A	16353844	C	A	16353844	3	1	121	1	0	0	0	0	1	0	0	0	3469	913	32	3	721	3	CLCNKA	1	16353844	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	14979124	16353844	232896777	2	36037										
ECE1	1889	broad.mit.edu	37	chr1	21582529	21582529	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gatgttggccagtgccgtctCaaagtccaagatctgctgca	11	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:21582529C>G	uc001bek.2	-	8	1006	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	ECE1_uc001bem.2_Missense_Mutation_p.E295Q|ECE1_uc001bej.2_Missense_Mutation_p.E299Q|ECE1_uc001bei.2_Missense_Mutation_p.E308Q|ECE1_uc010odl.1_Missense_Mutation_p.E311Q|ECE1_uc009vqa.1_Missense_Mutation_p.E311Q	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	311	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		AGTGCCGTCTCAAAGTCCAAG	0.602													0	0	0	0.010771	0	36	8										G	21582529	C	G	21582529	3	3	121	1	0	0	0	0	1	0	0	0	4889	835	29	1	1429	1	ECE1	1	21582529	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5228685	21582529	227668092	3	36038										
NBPF3	84224	broad.mit.edu	37	chr1	21795335	21795335	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagttcagaaacctcaaacaGaaatgtcttgtaactcaagt	6	9	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:21795335G>T	uc001ber.2	+	3	638	c.288G>T	c.(286-288)CAG>CAT	p.Q96H	NBPF3_uc001bes.2_Missense_Mutation_p.Q40H|NBPF3_uc009vqb.2_Missense_Mutation_p.Q96H|NBPF3_uc010odm.1_Intron	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	96						cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACCTCAAACAGAAATGTCTTG	0.458											OREG0013205	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.5997e-14	0.002299	3.9692e-14	16	0										T	21795335	G	T	21795335	3	4	121	1	0	0	0	0	1	0	0	0	10197	933	33	3	294	3	NBPF3	1	21795335	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	212806	21795335	227455286	4	36039										
NBPF3	84224	broad.mit.edu	37	chr1	21795351	21795351	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aacagaaatgtcttgtaactCaagtggcctacttcctggcc	8	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:21795351C>G	uc001ber.2	+	3	654	c.304C>G	c.(304-306)CAA>GAA	p.Q102E	NBPF3_uc001bes.2_Missense_Mutation_p.Q46E|NBPF3_uc009vqb.2_Missense_Mutation_p.Q102E|NBPF3_uc010odm.1_Intron	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	102						cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCTTGTAACTCAAGTGGCCTA	0.453											OREG0013205	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	10	0										G	21795351	C	G	21795351	3	3	121	1	0	0	0	0	1	0	0	0	10197	827	29	1	310	1	NBPF3	1	21795351	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	16	21795351	227455270	5	36040										
FGR	2268	broad.mit.edu	37	chr1	27949568	27949568	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttacgtattgttcaggatgTggaacttctcgcccttggtg	11	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:27949568T>C	uc001boj.2	-	2	460	c.314A>G	c.(313-315)CAC>CGC	p.H105R	FGR_uc001bok.2_Missense_Mutation_p.H105R|FGR_uc001bol.2_Missense_Mutation_p.H105R|FGR_uc001bom.2_Missense_Mutation_p.H105R	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	105	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTTCAGGATGTGGAACTTCTC	0.383													0	0	0	0.00361	0	38	0										C	27949568	T	C	27949568	3	2	121	1	0	0	0	0	1	0	0	0	5874	1696	59	5	1315	5	FGR	1	27949568	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	6154217	27949568	221301053	6	36041										
CSMD2	114784	broad.mit.edu	37	chr1	34083156	34083156	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acatcattcaccaagtagcgCtcgccagtcttcaccccgtt	6	16	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:34083156C>A	uc001bxn.1	-	38	5798	c.5769G>T	c.(5767-5769)GAG>GAT	p.E1923D	CSMD2_uc001bxm.1_Missense_Mutation_p.E1963D|CSMD2_uc001bxo.1_Missense_Mutation_p.E836D	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1923	Sushi 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCAAGTAGCGCTCGCCAGTCT	0.567													1	0	4.3181e-19	0.002836	4.9076e-19	30	1										A	34083156	C	A	34083156	3	1	121	1	0	0	0	0	1	0	0	0	3945	796	28	4	4822	4	CSMD2	1	34083156	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6133588	34083156	215167465	7	36042										
THRAP3	9967	broad.mit.edu	37	chr1	36769407	36769407	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttcccctcagcatgatgaccGtgaaggcgaaggcagtgaca	12	11	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:36769407G>A	uc001cae.3	+	12	2881	c.2657G>A	c.(2656-2658)CGT>CAT	p.R886H	THRAP3_uc001caf.3_Missense_Mutation_p.R886H|C1orf113_uc010oia.1_5'Flank	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	886					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CATGATGACCGTGAAGGCGAA	0.587			T	USP6	aneurysmal bone cysts								0	0	0	0.00361	0	68	8										A	36769407	G	A	36769407	3	1	121	1	0	0	0	0	1	0	0	0	15871	1145	40	2	2695	2	THRAP3	1	36769407	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2686251	36769407	212481214	8	36043										
MACF1	23499	broad.mit.edu	37	chr1	39800781	39800781	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcaggcaaaaaagagcaggGaaatttccttaaaggaattt	10	5	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:39800781G>T	uc010oiu.1	+	1	3972	c.3841G>T	c.(3841-3843)GAA>TAA	p.E1281*	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2846					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAAGAGCAGGGAAATTTCCTT	0.363													1	0	1.33834e-09	0.007413	1.42385e-09	16	3										T	39800781	G	T	39800781	4	4	121	1	0	0	0	0	0	1	0	0	9144	1175	41	3	8612	3	MACF1	1	39800781	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3031374	39800781	209449840	9	36044										
NT5C1A	84618	broad.mit.edu	37	chr1	40131301	40131301	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agggtacagctcccgcagccGcctgttcacggcctccagag	12	16	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:40131301G>A	uc001cdq.1	-	3	325	c.325C>T	c.(325-327)CGG>TGG	p.R109W		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	109					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCCCGCAGCCGCCTGTTCACG	0.562													0	0	0	0.003271	0	27	1										A	40131301	G	A	40131301	3	1	121	1	0	0	0	0	1	0	0	0	10685	1086	38	2	797	2	NT5C1A	1	40131301	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	330520	40131301	209119320	10	36045										
RNF11	26994	broad.mit.edu	37	chr1	51702486	51702486	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctccctgcttcacgagtctCagtccgaccgggctagcttt	9	15	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:51702486C>G	uc001csi.3	+	1	542	c.58C>G	c.(58-60)CAG>GAG	p.Q20E		NM_014372	NP_055187	Q9Y3C5	RNF11_HUMAN	ring finger protein 11	20					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	DNA binding|protein binding|zinc ion binding				0						TCACGAGTCTCAGTCCGACCG	0.637													0	0	0	0.004878	0	33	2										G	51702486	C	G	51702486	3	3	121	1	0	0	0	0	1	0	0	0	13424	827	29	1	60	1	RNF11	1	51702486	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	11571185	51702486	197548135	11	36046										
MRPL37	51253	broad.mit.edu	37	chr1	54670971	54670971	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctctttttgtcttcaagcccGgtcatcgtggacaacctaat	7	12	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:54670971G>A	uc001cxa.3	+	3	611	c.534G>A	c.(532-534)CCG>CCA	p.P178P	MRPL37_uc009vzp.2_Intron|MRPL37_uc001cxb.1_Silent_p.P178P|MRPL37_uc001cxc.3_5'UTR|MRPL37_uc010oob.1_RNA	NM_016491	NP_057575	Q9BZE1	RM37_HUMAN	mitochondrial ribosomal protein L37 precursor	178					translation	mitochondrial ribosome	structural constituent of ribosome				0						CTTCAAGCCCGGTCATCGTGG	0.448													0	0	0	0.00499	0	16	3										A	54670971	G	A	54670971	2	1	121	1	0	0	0	0	0	0	0	1	9800	1103	39	2		2	MRPL37	1	54670971	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2968485	54670971	194579650	12	36047										
C1orf173	127254	broad.mit.edu	37	chr1	75039034	75039034	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccccttttccctgtactatgTcagcatctctgtgctggggc	9	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:75039034T>A	uc001dgg.2	-	14	2579	c.2360A>T	c.(2359-2361)GAC>GTC	p.D787V		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	787	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTGTACTATGTCAGCATCTCT	0.517													0	0	0	0.00361	0	60	2										A	75039034	T	A	75039034	3	1	121	1	0	0	0	0	1	0	0	0	2014	1667	58	5	2236	5	C1orf173	1	75039034	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	20368063	75039034	174211587	13	36048										
LRRC8D	55144	broad.mit.edu	37	chr1	90398656	90398656	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccttgcggaagttgcatcacTtaatgacattcagccaactt	7	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:90398656T>A	uc001dnm.2	+	3	454	c.29T>A	c.(28-30)CTT>CAT	p.L10H	LRRC8D_uc001dnn.2_Missense_Mutation_p.L10H	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	10						integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GTTGCATCACTTAATGACATT	0.378													0	0	0	0.004482	0	5	46										A	90398656	T	A	90398656	3	1	121	1	0	0	0	0	1	0	0	0	9024	1609	56	5	31	5	LRRC8D	1	90398656	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	15359622	90398656	158851965	14	36049										
ZNF644	84146	broad.mit.edu	37	chr1	91404364	91404364	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctgtttcataactatctttCttttcagcagaattaagttt	4	7	5	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:91404364C>G	uc001dnw.2	-	3	2689	c.2547G>C	c.(2545-2547)AAG>AAC	p.K849N	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.K849N	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AACTATCTTTCTTTTCAGCAG	0.358													0	0	0	0.001368	0	10	3										G	91404364	C	G	91404364	3	3	121	1	0	0	0	0	1	0	0	0	18057	912	32	1	1452	1	ZNF644	1	91404364	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1005708	91404364	157846257	15	36050										
HFM1	164045	broad.mit.edu	37	chr1	91784664	91784664	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccagttgtttggatacatgcAgagagttttcccaaagttta	9	7	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:91784664A>G	uc001doa.3	-	25	2883	c.2783T>C	c.(2782-2784)CTG>CCG	p.L928P	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.L607P|HFM1_uc001dob.3_Intron|HFM1_uc010osv.1_Missense_Mutation_p.L612P	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	928	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GGATACATGCAGAGAGTTTTC	0.338													0	0	0	0.007291	0	20	5										G	91784664	A	G	91784664	3	3	121	1	0	0	0	0	1	0	0	0	7083	188	7	5	1584	5	HFM1	1	91784664	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	380300	91784664	157465957	16	36051										
NTNG1	22854	broad.mit.edu	37	chr1	107979293	107979293	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcttgtttctacagagtgttAttgtaaccctttgggctcaa	8	8	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:107979293A>T	uc001dvh.3	+	7	1980	c.1262A>T	c.(1261-1263)TAT>TTT	p.Y421F	NTNG1_uc001dvf.3_Intron|NTNG1_uc010out.1_Missense_Mutation_p.Y387F|NTNG1_uc001dvc.3_Intron|NTNG1_uc001dvi.2_5'UTR|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_Intron|NTNG1_uc009wem.2_Intron	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	421	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		ACAGAGTGTTATTGTAACCCT	0.453													0	0	0	0.008871	0	15	18										T	107979293	A	T	107979293	3	4	121	1	0	0	0	0	1	0	0	0	10704	449	16	5	1418	5	NTNG1	1	107979293	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	16194629	107979293	141271328	17	36052										
PTPN22	26191	broad.mit.edu	37	chr1	114380599	114380599	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaaacaagaatcatgtggttGagattccaaataagaaaagt	8	4	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:114380599G>C	uc001eds.2	-	13	1553	c.1423C>G	c.(1423-1425)CAA>GAA	p.Q475E	PTPN22_uc009wgq.2_Missense_Mutation_p.Q420E|PTPN22_uc010owo.1_Missense_Mutation_p.Q231E|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.Q475E|PTPN22_uc009wgs.2_Missense_Mutation_p.Q348E|PTPN22_uc001edu.2_Missense_Mutation_p.Q475E	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	475					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCATGTGGTTGAGATTCCAAA	0.393													0	0	0	0.00874	0	34	2										C	114380599	G	C	114380599	3	2	121	1	0	0	0	0	1	0	0	0	12787	1299	45	1	1059	1	PTPN22	1	114380599	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6401306	114380599	134870022	18	36053										
PDE4DIP	9659	broad.mit.edu	37	chr1	144864173	144864173	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agggaaagacgttcctccctGaaatgcaagacctcttgctg	10	11	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:144864173G>A	uc001elw.3	-	36	6213	c.5922C>T	c.(5920-5922)TTC>TTT	p.F1974F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.F1868F|PDE4DIP_uc001elv.3_Silent_p.F981F|PDE4DIP_uc001ema.2_Silent_p.F161F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1974	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTTCCTCCCTGAAATGCAAGA	0.458			T	PDGFRB	MPD								0	0	0	0.006214	0	8	321										A	144864173	G	A	144864173	2	1	121	1	0	0	0	0	0	0	0	1	11643	1281	45	1		1	PDE4DIP	1	144864173	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	30483574	144864173	104386448	19	36054										
PDE4DIP	9659	broad.mit.edu	37	chr1	144877097	144877097	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccctgggcgagttgctcccgGaagctctgtcccaggtagta	13	13	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:144877097G>A	uc001elw.3	-	28	4881	c.4590C>T	c.(4588-4590)TTC>TTT	p.F1530F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.F1486F|PDE4DIP_uc001elv.3_Silent_p.F537F	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1530					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GTTGCTCCCGGAAGCTCTGTC	0.493			T	PDGFRB	MPD								0	0	0	0.010729	0	10	13										A	144877097	G	A	144877097	2	1	121	1	0	0	0	0	0	0	0	1	11643	1165	41	1		1	PDE4DIP	1	144877097	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	12924	144877097	104373524	20	36055										
NBPF10	100132406	broad.mit.edu	37	chr1	146399628	146399628	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctggaatcatctgcccccagGtaacactgaatactcaggag	9	12	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:146399628G>T	uc001emp.3	+	14	2577	c.1379_splice	c.e14+1	p.R460_splice	uc010ozk.1_Splice_Site	NM_017940	NP_060410	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC55672												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTGCCCCCAGGTAACACTGAA	0.418													1	0	2.79145e-41	0.00361	3.29629e-41	40	485										T	146399628	G	T	146399628	5	4	121	1	0	0	0	0	0	0	1	0	10193	1276	44	4		4	NBPF10	1	146399628	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1522531	146399628	102850993	21	36056										
TARS2	80222	broad.mit.edu	37	chr1	150478109	150478109	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caggactggtcagtgacctgGatgcagactctggactgacc	13	11	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:150478109G>C	uc001euq.2	+	17	1943	c.1936G>C	c.(1936-1938)GAT>CAT	p.D646H	TARS2_uc001eur.2_Missense_Mutation_p.D564H|TARS2_uc009wlt.2_Missense_Mutation_p.D272H|TARS2_uc009wls.2_Missense_Mutation_p.D516H|ECM1_uc010pce.1_5'Flank|ECM1_uc010pcf.1_5'Flank|ECM1_uc001eus.2_5'Flank|ECM1_uc001eut.2_5'Flank|ECM1_uc001euu.2_5'Flank|ECM1_uc001euv.2_5'Flank|ECM1_uc009wlu.2_5'Flank	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	646					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CAGTGACCTGGATGCAGACTC	0.532													0	0	0	0.00361	0	40	185										C	150478109	G	C	150478109	3	2	121	1	0	0	0	0	1	0	0	0	15557	1174	41	1	2002	1	TARS2	1	150478109	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4078481	150478109	98772512	22	36057										
PRUNE	58497	broad.mit.edu	37	chr1	151006538	151006538	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagtaactccctgatttctgGcctgagtcaagatgaggagg	12	8	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:151006538G>A	uc001ewh.1	+	8	1326	c.1190G>A	c.(1189-1191)GGA>GAA	p.G397E	PRUNE_uc001ewi.1_Missense_Mutation_p.G215D|PRUNE_uc010pco.1_Missense_Mutation_p.G165D|PRUNE_uc001ewj.1_Missense_Mutation_p.G112D|PRUNE_uc001ewk.1_Missense_Mutation_p.G162D|BNIPL_uc009wmi.2_5'Flank|BNIPL_uc001ewl.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	397	Essential for homodimerization.					cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGATTTCTGGCCTGAGTCAA	0.562													0	0	0	0.002299	0	18	102										A	151006538	G	A	151006538	3	1	121	1	0	0	0	0	1	0	0	0	12640	1203	42	2	1220	2	PRUNE	1	151006538	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	528429	151006538	98244083	23	36058										
FLG2	388698	broad.mit.edu	37	chr1	152328035	152328035	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccatgttgtccaaagccagAggactgacctgagcctgatc	10	13	0	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:152328035A>C	uc001ezw.3	-	3	2300	c.2227T>G	c.(2227-2229)TCT>GCT	p.S743A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	743	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAAAGCCAGAGGACTGACCT	0.507													0	0	0	0.008291	0	11	621										C	152328035	A	C	152328035	3	2	121	1	0	0	0	0	1	0	0	0	5923	304	11	5	4952	5	FLG2	1	152328035	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1321497	152328035	96922586	24	36059										
CRTC2	200186	broad.mit.edu	37	chr1	153921785	153921785	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtggggctgggtaggcagaaCcagacttggggagctgtatg	19	6	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:153921785C>G	uc010ped.1	-	12	1550	c.1480G>C	c.(1480-1482)GTT>CTT	p.V494L	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Missense_Mutation_p.V30L	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	494					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GTAGGCAGAACCAGACTTGGG	0.582													0	0	0	0.010504	0	16	119										G	153921785	C	G	153921785	3	3	121	1	0	0	0	0	1	0	0	0	3900	507	18	4	613	4	CRTC2	1	153921785	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1593750	153921785	95328836	25	36060										
NUP210L	91181	broad.mit.edu	37	chr1	153998045	153998045	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccagttatggttgtttggttGactccaaaaggttctataga	10	6	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:153998045G>A	uc001fdw.2	-	30	4167	c.4095C>T	c.(4093-4095)GTC>GTT	p.V1365V	NUP210L_uc009woq.2_Silent_p.V274V|NUP210L_uc010peh.1_Silent_p.V1365V	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1365						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTGTTTGGTTGACTCCAAAAG	0.413													0	0	0	0.00361	0	113	50										A	153998045	G	A	153998045	2	1	121	1	0	0	0	0	0	0	0	1	10761	1277	45	1		1	NUP210L	1	153998045	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	76260	153998045	95252576	26	36061										
PYGO2	90780	broad.mit.edu	37	chr1	154932130	154932130	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acctccagtgctgtagcctgGgggtacctggcccgccatgc	13	15	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:154932130G>A	uc001fft.2	-	3	552	c.346C>T	c.(346-348)CCA>TCA	p.P116S		NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	116	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGTAGCCTGGGGGTACCTGG	0.682													0	0	0	0.004007	0	12	2										A	154932130	G	A	154932130	3	1	121	1	0	0	0	0	1	0	0	0	12864	1232	43	2	878	2	PYGO2	1	154932130	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	934085	154932130	94318491	27	36062										
ADAM15	8751	broad.mit.edu	37	chr1	155030787	155030787	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcctctgctgggctccatccGggatctactctgggagacaa	12	13	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:155030787G>A	uc001fgr.1	+	15	1888	c.1787G>A	c.(1786-1788)CGG>CAG	p.R596Q	ADAM15_uc001fgq.1_Missense_Mutation_p.R281Q|ADAM15_uc010pet.1_Missense_Mutation_p.R580Q|ADAM15_uc010peu.1_Missense_Mutation_p.R613Q|ADAM15_uc001fgt.1_Missense_Mutation_p.R596Q|ADAM15_uc010pev.1_Missense_Mutation_p.R606Q|ADAM15_uc001fgs.1_Missense_Mutation_p.R596Q|ADAM15_uc001fgu.1_Missense_Mutation_p.R596Q|ADAM15_uc001fgw.1_Missense_Mutation_p.R596Q|ADAM15_uc001fgv.1_Missense_Mutation_p.R596Q|ADAM15_uc001fgx.1_Missense_Mutation_p.R596Q|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'UTR	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	596	Extracellular (Potential).|Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GGCTCCATCCGGGATCTACTC	0.597													0	0	0	0.007413	0	13	65										A	155030787	G	A	155030787	3	1	121	1	0	0	0	0	1	0	0	0	237	1116	39	2	1845	2	ADAM15	1	155030787	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	98657	155030787	94219834	28	36063										
NES	10763	broad.mit.edu	37	chr1	156640230	156640230	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccagggcttcagccctcccCtgcaccccccagctagcctc	7	23	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:156640230C>T	uc001fpq.2	-	4	3883	c.3750G>A	c.(3748-3750)CAG>CAA	p.Q1250Q		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1250	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGCCCTCCCCTGCACCCCCC	0.662													0	0	0	0.00361	0	49	216										T	156640230	C	T	156640230	2	4	121	1	0	0	0	0	0	0	0	1	10337	680	24	2		2	NES	1	156640230	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1609443	156640230	92610391	29	36064										
OR10R2	343406	broad.mit.edu	37	chr1	158450082	158450082	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcctgctattgggtgtgatgGgttatgatcgctatgctgcc	14	8	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:158450082G>C	uc010pik.1	+	1	415	c.415G>C	c.(415-417)GGT>CGT	p.G139R	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	139	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					GGGTGTGATGGGTTATGATCG	0.488													0	0	0	0.00361	0	341	134										C	158450082	G	C	158450082	3	2	121	1	0	0	0	0	1	0	0	0	10917	1232	43	4	417	4	OR10R2	1	158450082	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1809852	158450082	90800539	30	36065										
OR6N2	81442	broad.mit.edu	37	chr1	158747267	158747267	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tacataggtgtgtgcagagcTgcatccagtcggatgactga	13	8	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:158747267T>C	uc010pir.1	-	1	159	c.159A>G	c.(157-159)GCA>GCG	p.A53A		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TGTGCAGAGCTGCATCCAGTC	0.463													0	0	0	0.00361	0	174	58										C	158747267	T	C	158747267	2	2	121	1	0	0	0	0	0	0	0	1	11207	1567	55	5		5	OR6N2	1	158747267	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	297185	158747267	90503354	31	36066										
CADM3	57863	broad.mit.edu	37	chr1	159166685	159166685	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgtctgcctcgacagccccCagcagtacctatgggagaag	11	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:159166685C>T	uc001ftl.2	+	7	929	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	CADM3_uc009wsy.1_Nonsense_Mutation_p.Q217*|CADM3_uc001ftk.2_Nonsense_Mutation_p.Q297*|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	263	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					CGACAGCCCCCAGCAGTACCT	0.527													0	0	0	0.00361	0	92	30										T	159166685	C	T	159166685	4	4	121	1	0	0	0	0	0	1	0	0	2568	595	21	2	919	2	CADM3	1	159166685	Nonsense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	419418	159166685	90083936	32	36067										
CRP	1401	broad.mit.edu	37	chr1	159683378	159683378	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcatacttcagtgcccgccaGttcaggacattaggactgaa	9	11	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:159683378G>A	uc001ftw.2	-	2	716	c.612C>T	c.(610-612)AAC>AAT	p.N204N	CRP_uc001ftx.1_Silent_p.N71N|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	204	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	GTGCCCGCCAGTTCAGGACAT	0.532													0	0	0	0.012319	0	20	120										A	159683378	G	A	159683378	2	1	121	1	0	0	0	0	0	0	0	1	3895	1020	36	2		2	CRP	1	159683378	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	516693	159683378	89567243	33	36068										
NCSTN	23385	broad.mit.edu	37	chr1	160326392	160326392	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctttggtctgcactcaggtGacgggcctcttcaacattac	9	13	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:160326392G>T	uc001fvx.2	+	15	1766	c.1642G>T	c.(1642-1644)GAC>TAC	p.D548Y	NCSTN_uc001fvy.2_Missense_Mutation_p.D528Y|NCSTN_uc010pjf.1_Missense_Mutation_p.D410Y|NCSTN_uc001fvz.2_Missense_Mutation_p.D328Y|NCSTN_uc010pjg.1_Missense_Mutation_p.D290Y	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	548	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCACTCAGGTGACGGGCCTCT	0.512													1	0	2.93687e-30	0.00361	3.4315e-30	48	251										T	160326392	G	T	160326392	3	4	121	1	0	0	0	0	1	0	0	0	10241	1290	45	3	1700	3	NCSTN	1	160326392	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	643014	160326392	88924229	34	36069										
SLAMF6	114836	broad.mit.edu	37	chr1	160466111	160466111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcctgcaggaaactccaggGgaagagttactgactccccc	10	14	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:160466111G>A	uc001fwe.1	-	2	182	c.122C>T	c.(121-123)CCC>CTC	p.P41L	SLAMF6_uc001fwd.1_Missense_Mutation_p.P41L|SLAMF6_uc010pjh.1_Intron|SLAMF6_uc010pji.1_Intron|SLAMF6_uc010pjj.1_Intron|SLAMF6_uc009wtm.1_Intron	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	41	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			AAACTCCAGGGGAAGAGTTAC	0.438													0	0	0	0.00361	0	47	412										A	160466111	G	A	160466111	3	1	121	1	0	0	0	0	1	0	0	0	14368	1232	43	2	904	2	SLAMF6	1	160466111	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	139719	160466111	88784510	35	36070										
NDUFS2	4720	broad.mit.edu	37	chr1	161176202	161176202	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttcttacttctcagatgtgGaccctccaaaggacacaatt	6	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:161176202G>A	uc001fyv.2	+	4	656	c.208G>A	c.(208-210)GAC>AAC	p.D70N	NDUFS2_uc010pki.1_5'UTR|NDUFS2_uc001fyw.2_Missense_Mutation_p.D70N|NDUFS2_uc010pkj.1_Missense_Mutation_p.D19N|NDUFS2_uc001fyx.2_Missense_Mutation_p.D70N|NDUFS2_uc001fyy.1_Missense_Mutation_p.D19N	NM_004550	NP_004541	O75306	NDUS2_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 2	70					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding			skin(1)	1	all_cancers(52;1.16e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		NADH(DB00157)	CTCAGATGTGGACCCTCCAAA	0.473													0	0	0	0.004007	0	12	98										A	161176202	G	A	161176202	3	1	121	1	0	0	0	0	1	0	0	0	10292	1174	41	1	218	1	NDUFS2	1	161176202	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	710091	161176202	88074419	36	36071										
RXRG	6258	broad.mit.edu	37	chr1	165414106	165414106	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atagcctgcgggaaacttcaTgaagtgagaataatttccat	9	7	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:165414106T>C	uc001gda.2	-	1	325	c.25A>G	c.(25-27)ATG>GTG	p.M9V	RXRG_uc001gdb.1_Missense_Mutation_p.M9V	NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	9	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	GGAAACTTCATGAAGTGAGAA	0.473													0	0	0	0.00361	0	51	108										C	165414106	T	C	165414106	3	2	121	1	0	0	0	0	1	0	0	0	13765	1464	51	5	1463	5	RXRG	1	165414106	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	4237904	165414106	83836515	37	36072										
LRRC52	440699	broad.mit.edu	37	chr1	165532930	165532930	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggctcacaggtgtgtgtgctGtgctctaccagaacacccgc	12	13	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:165532930G>C	uc001gde.2	+	2	867	c.811G>C	c.(811-813)GTG>CTG	p.V271L	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	271	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					TGTGTGTGCTGTGCTCTACCA	0.582													0	0	0	0.001368	0	12	95										C	165532930	G	C	165532930	3	2	121	1	0	0	0	0	1	0	0	0	9010	1377	48	4	817	4	LRRC52	1	165532930	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	118824	165532930	83717691	38	36073										
ILDR2	387597	broad.mit.edu	37	chr1	166891923	166891923	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcccatgacacctgaccaaTagtcaggattgctctccaag	7	14	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:166891923T>C	uc001gdx.1	-	8	1174	c.1118A>G	c.(1117-1119)TAT>TGT	p.Y373C		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	373	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						ACCTGACCAATAGTCAGGATT	0.552													0	0	0	0.00361	0	313	252										C	166891923	T	C	166891923	3	2	121	1	0	0	0	0	1	0	0	0	7710	1406	49	5	813	5	ILDR2	1	166891923	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	1358993	166891923	82358698	39	36074										
CD247	919	broad.mit.edu	37	chr1	167487650	167487650	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acacgtcggccctacctgtaAtcggcaactgtgcctgcagg	11	14	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:167487650A>T	uc001gei.3	-	1	198	c.53T>A	c.(52-54)ATT>AAT	p.I18N	CD247_uc001gej.3_Missense_Mutation_p.I18N|CD247_uc001gek.2_Missense_Mutation_p.I18N	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	18					interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			CCTACCTGTAATCGGCAACTG	0.587													0	0	0	0.002299	0	15	145										T	167487650	A	T	167487650	3	4	121	1	0	0	0	0	1	0	0	0	2988	101	4	5	473	5	CD247	1	167487650	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	595727	167487650	81762971	40	36075										
DCAF6	55827	broad.mit.edu	37	chr1	167962475	167962475	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttttttagggaattatgcaGgtcgagggactactggaatg	13	5	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:167962475G>A	uc001gew.2	+	7	942	c.700G>A	c.(700-702)GGT>AGT	p.G234S	DCAF6_uc001gev.2_Missense_Mutation_p.G234S|DCAF6_uc001gex.2_Missense_Mutation_p.G234S|DCAF6_uc010plk.1_Missense_Mutation_p.G203S|DCAF6_uc001gey.2_Missense_Mutation_p.G87S	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	234					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAATTATGCAGGTCGAGGGAC	0.303													0	0	0	0.00361	0	44	57										A	167962475	G	A	167962475	3	1	121	1	0	0	0	0	1	0	0	0	4274	1000	35	2	726	2	DCAF6	1	167962475	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	474825	167962475	81288146	41	36076										
FMO2	2327	broad.mit.edu	37	chr1	171162616	171162616	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	taaacttctggaatatttcaGgatttttgctaaaaaatttg	6	4	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:171162616G>A	uc001ghk.1	+	3	392	c.275G>A	c.(274-276)AGG>AAG	p.R92K	FMO2_uc010pmd.1_5'UTR	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	92					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAATATTTCAGGATTTTTGCT	0.343													0	0	0	0.00308	0	7	58										A	171162616	G	A	171162616	3	1	121	1	0	0	0	0	1	0	0	0	5955	1000	35	2	281	2	FMO2	1	171162616	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3200141	171162616	78088005	42	36077										
TNN	63923	broad.mit.edu	37	chr1	175086217	175086217	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggagagaccagggaggttccGgtggggaaggagcagagtag	21	5	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:175086217G>A	uc001gkl.1	+	10	2375	c.2262G>A	c.(2260-2262)CCG>CCA	p.P754P		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	754	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGGAGGTTCCGGTGGGGAAGG	0.637													0	0	0	0.001855	0	5	146										A	175086217	G	A	175086217	2	1	121	1	0	0	0	0	0	0	0	1	16320	1103	39	2		2	TNN	1	175086217	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3923601	175086217	74164404	43	36078										
CEP350	9857	broad.mit.edu	37	chr1	180053254	180053254	+	Frame_Shift_Del	DEL	A	A	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accagctgaagaaggaacagAaaaaaaggcaaaaggaaaga							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:180053254delA	uc001gnt.2	+	31	6609	c.6226delA	c.(6226-6228)AAAfs	p.K2076fs	CEP350_uc009wxl.2_Frame_Shift_Del_p.K2075fs|CEP350_uc001gnv.2_Frame_Shift_Del_p.K211fs|CEP350_uc001gnw.1_5'Flank	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2076	Potential.					centrosome|nucleus|spindle				ovary(4)	4						GAAGGAACAGAAAAAAAGGCA	0.423																		2	4	---	---								-	180053254	A	-	180053254	7	5	121	1	0	1	0	1	0	0	0	0	3254	247	9	0	6344	0	CEP350	1	180053254	Frame_Shift_Del	DEL	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4967037	180053254	69197367	44	36079										
KIF14	9928	broad.mit.edu	37	chr1	200558410	200558410	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atatatttcctgttcaagatGctgctttgccttttctaatt	5	8	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:200558410G>T	uc010ppk.1	-	18	3488	c.3049C>A	c.(3049-3051)CAT>AAT	p.H1017N	KIF14_uc010ppj.1_Missense_Mutation_p.H526N	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1017	Potential.|Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TGTTCAAGATGCTGCTTTGCC	0.323													1	0	6.49762e-13	0.006122	7.09412e-13	16	33										T	200558410	G	T	200558410	3	4	121	1	0	0	0	0	1	0	0	0	8276	1319	46	4	1949	4	KIF14	1	200558410	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	20505156	200558410	48692211	45	36080										
GOLT1A	127845	broad.mit.edu	37	chr1	204170901	204170901	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagaaccaaaaggtcttcctCaggccaatgatgagggacag	11	9	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:204170901C>T	uc001has.1	-	3	342	c.156G>A	c.(154-156)CTG>CTA	p.L52L	GOLT1A_uc001hat.1_Silent_p.L52L	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	golgi transport 1 homolog A	52	Helical; Name=2; (Potential).				protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane					0	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			AGGTCTTCCTCAGGCCAATGA	0.592													0	0	0	0.00361	0	66	24										T	204170901	C	T	204170901	2	4	121	1	0	0	0	0	0	0	0	1	6570	813	29	1		1	GOLT1A	1	204170901	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3612491	204170901	45079720	46	36081										
MFSD4	148808	broad.mit.edu	37	chr1	205561360	205561360	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcaagcctgggcctgtttctCagcagcaccttccccagcat	9	16	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:205561360C>T	uc001hcv.3	+	7	1328	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L	MFSD4_uc010prk.1_Silent_p.L327L|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Silent_p.L359L|MFSD4_uc009xbn.2_RNA	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	414	Helical; (Potential).				transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GCCTGTTTCTCAGCAGCACCT	0.622											OREG0014160	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	35	13										T	205561360	C	T	205561360	2	4	121	1	0	0	0	0	0	0	0	1	9533	813	29	1		1	MFSD4	1	205561360	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1390459	205561360	43689261	47	36082										
SRGAP2	23380	broad.mit.edu	37	chr1	206566186	206566186	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accccacgctcccctgactcCacggccaacgttcgcattga	7	19	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:206566186C>T	uc001hdy.2	+	3	699	c.366C>T	c.(364-366)TCC>TCT	p.S122S	SRGAP2_uc009xbt.2_Silent_p.S46S|SRGAP2_uc010prt.1_Silent_p.S46S|SRGAP2_uc001hdx.2_Silent_p.S122S|SRGAP2_uc010pru.1_Silent_p.S46S|SRGAP2_uc010prv.1_Silent_p.S46S	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	209					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					CCCCTGACTCCACGGCCAACG	0.532													0	0	0	0.000602	0	3	39										T	206566186	C	T	206566186	2	4	121	1	0	0	0	0	0	0	0	1	15145	581	21	2		2	SRGAP2	1	206566186	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1004826	206566186	42684435	48	36083										
TRAF3IP3	80342	broad.mit.edu	37	chr1	209935923	209935923	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctccctcaggcatctgcaggGatctgtctgaccacctctcc	8	17	5	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:209935923G>T	uc001hho.2	+	4	699	c.409G>T	c.(409-411)GAT>TAT	p.D137Y	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.D117Y|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.D137Y|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.D117Y|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.D137Y	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	137	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CATCTGCAGGGATCTGTCTGA	0.587													1	0	7.38237e-10	0.00632	7.86665e-10	20	5										T	209935923	G	T	209935923	3	4	121	1	0	0	0	0	1	0	0	0	16439	1174	41	3	415	3	TRAF3IP3	1	209935923	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3369737	209935923	39314698	49	36084										
ESRRG	2104	broad.mit.edu	37	chr1	216737663	216737663	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	actgtcggggacagtagggtCaggcatggcatagatcttct	14	8	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:216737663C>T	uc001hkw.1	-	5	926	c.760G>A	c.(760-762)GAC>AAC	p.D254N	ESRRG_uc001hky.1_Missense_Mutation_p.D231N|ESRRG_uc009xdp.1_Missense_Mutation_p.D231N|ESRRG_uc001hkz.1_Missense_Mutation_p.D192N|ESRRG_uc010puc.1_Missense_Mutation_p.D231N|ESRRG_uc001hla.1_Missense_Mutation_p.D231N|ESRRG_uc001hlb.1_Missense_Mutation_p.D231N|ESRRG_uc010pud.1_Missense_Mutation_p.D62N|ESRRG_uc001hlc.1_Missense_Mutation_p.D231N|ESRRG_uc001hld.1_Missense_Mutation_p.D231N|ESRRG_uc001hkx.1_Missense_Mutation_p.D266N|ESRRG_uc009xdo.1_Missense_Mutation_p.D231N|ESRRG_uc001hle.1_Missense_Mutation_p.D231N	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	254					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	ACAGTAGGGTCAGGCATGGCA	0.493													0	0	0	0.011902	0	37	4										T	216737663	C	T	216737663	3	4	121	1	0	0	0	0	1	0	0	0	5262	826	29	1	628	1	ESRRG	1	216737663	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6801740	216737663	32512958	50	36085										
LYST	1130	broad.mit.edu	37	chr1	235964228	235964228	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctaataattttcaaaaaactCtcaaatacatgggcaagcac	4	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:235964228C>T	uc001hxj.2	-	9	4057	c.3882G>A	c.(3880-3882)GAG>GAA	p.E1294E	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.E1294E	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	1294					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCAAAAAACTCTCAAATACAT	0.313									Chediak-Higashi_syndrome				0	0	0	0.001984	0	7	23										T	235964228	C	T	235964228	2	4	121	1	0	0	0	0	0	0	0	1	9128	912	32	1		1	LYST	1	235964228	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	19226565	235964228	13286393	51	36086										
MTR	4548	broad.mit.edu	37	chr1	237016251	237016251	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atttgtattgcccttagtctGgcatggacatggggatagtg	13	6	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:237016251G>A	uc001hyi.3	+	18	2239	c.1816G>A	c.(1816-1818)GGC>AGC	p.G606S	MTR_uc010pxw.1_Missense_Mutation_p.G199S|MTR_uc010pxx.1_Missense_Mutation_p.G606S|MTR_uc010pxy.1_Intron	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	606	Pterin-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CCCTTAGTCTGGCATGGACAT	0.299													0	0	0	0.004656	0	18	67										A	237016251	G	A	237016251	3	1	121	1	0	0	0	0	1	0	0	0	9958	1348	47	2	1886	2	MTR	1	237016251	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1052023	237016251	12234370	52	36087										
CHRM3	1131	broad.mit.edu	37	chr1	240072203	240072203	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cggaaaaggatgtccctggtCaaggagaagaaagcggccca	14	9	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:240072203C>G	uc001hyp.2	+	5	2231	c.1452C>G	c.(1450-1452)GTC>GTG	p.V484V		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	484	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TGTCCCTGGTCAAGGAGAAGA	0.517													0	0	0	0.002299	0	19	77										G	240072203	C	G	240072203	2	3	121	1	0	0	0	0	0	0	0	1	3378	813	29	1		1	CHRM3	1	240072203	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3055952	240072203	9178418	53	36088										
CHRM3	1131	broad.mit.edu	37	chr1	240072271	240072271	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catcatcacttggaccccatAcaacatcatggttctggtga	7	12	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:240072271A>T	uc001hyp.2	+	5	2299	c.1520A>T	c.(1519-1521)TAC>TTC	p.Y507F		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	507	Helical; Name=6; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TGGACCCCATACAACATCATG	0.502													0	0	0	0.011902	0	33	106										T	240072271	A	T	240072271	3	4	121	1	0	0	0	0	1	0	0	0	3378	391	14	5	1522	5	CHRM3	1	240072271	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	68	240072271	9178350	54	36089										
OR6F1	343169	broad.mit.edu	37	chr1	247875413	247875414	+	Frame_Shift_Del	DEL	AA	AA	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgatgtacacataggagacAaaggtgatgaggcatgaact					rs147403383		TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:247875413_247875414delAA	uc001idj.1	-	1	644_645	c.644_645delTT	c.(643-645)TTTfs	p.F215fs		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CATAGGAGACAAAGGTGATGAG	0.559																		136	96	---	---								-	247875414	AA	-	247875413	7	5	121	1	0	1	0	1	0	0	0	0	11201	127	5	0	285	0	OR6F1	1	247875413	Frame_Shift_Del	DEL	AA	TCGA-GV-A3QI-01A-11D-A21Z-08	7803142	247875413	1375208	55	36090										
OR6F1	343169	broad.mit.edu	37	chr1	247875858	247875858	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tataccaaatctccaggaagGagaggttgctcagaaagaag	11	7	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:247875858G>T	uc001idj.1	-	1	200	c.200C>A	c.(199-201)TCC>TAC	p.S67Y		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CTCCAGGAAGGAGAGGTTGCT	0.478													1	0	1.76689e-08	0.006214	1.85901e-08	8	65										T	247875858	G	T	247875858	3	4	121	1	0	0	0	0	1	0	0	0	11201	1174	41	3	730	3	OR6F1	1	247875858	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	445	247875858	1374763	56	36091										
OR2T10	127069	broad.mit.edu	37	chr1	248756394	248756394	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcaactgagttcatcttatGgatggtgaggatgatatagt	11	5	3	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr1:248756394G>C	uc010pzn.1	-	1	676	c.676C>G	c.(676-678)CAT>GAT	p.H226D		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCATCTTATGGATGGTGAGG	0.443													0	0	0	0.00632	0	22	78										C	248756394	G	C	248756394	3	2	121	1	0	0	0	0	1	0	0	0	11017	1348	47	4	265	4	OR2T10	1	248756394	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	880536	248756394	494227	57	36092										
ROCK2	9475	broad.mit.edu	37	chr2	11333916	11333916	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tatgtttacctggaatatccTtggaatttctttagcatctg	7	7	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:11333916T>C	uc002rbd.1	-	30	4125	c.3676A>G	c.(3676-3678)AGG>GGG	p.R1226G		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	1226	PH.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TGGAATATCCTTGGAATTTCT	0.299													0	0	0	0.00333	0	15	30										C	11333916	T	C	11333916	3	2	121	1	0	0	0	0	1	0	0	0	13518	1608	56	5	506	5	ROCK2	2	11333916	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08		11333916	231865457	58	36093										
ITSN2	50618	broad.mit.edu	37	chr2	24535214	24535214	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagaactcttgctgatccatCttcccatccttgtttaggtc	7	12	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:24535214C>G	uc002rfe.2	-	5	477	c.219G>C	c.(217-219)AAG>AAC	p.K73N	ITSN2_uc002rff.2_Missense_Mutation_p.K73N|ITSN2_uc002rfg.2_Missense_Mutation_p.K73N|ITSN2_uc010eyd.2_Missense_Mutation_p.K73N	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	73	EH 1.|Potential.|EF-hand 1.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGATCCATCTTCCCATCCT	0.453													0	0	0	0.00361	0	35	137										G	24535214	C	G	24535214	3	3	121	1	0	0	0	0	1	0	0	0	7927	912	32	1	5069	1	ITSN2	2	24535214	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	13201298	24535214	218664159	59	36094										
EPT1	85465	broad.mit.edu	37	chr2	26587758	26587758	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttctggctttctgctggtcgTattcaattttctgctaatgg	9	8	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:26587758T>A	uc010ykz.1	+	3	332	c.185T>A	c.(184-186)GTA>GAA	p.V62E	EPT1_uc010eyl.1_RNA	NM_033505	NP_277040	Q9C0D9	EPT1_HUMAN	selenoprotein I	62	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding				0						CTGCTGGTCGTATTCAATTTT	0.303													0	0	0	0.00623	0	26	17										A	26587758	T	A	26587758	3	1	121	1	0	0	0	0	1	0	0	0	5199	1638	57	5	195	5	EPT1	2	26587758	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2052544	26587758	216611615	60	36095										
CAD	790	broad.mit.edu	37	chr2	27448663	27448663	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctctggctttgcctctaacAgggaggagctctctgctctc	11	13	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:27448663A>G	uc002rji.2	+	12	1873	c.1711A>G	c.(1711-1713)AGG>GGG	p.R571G	CAD_uc010eyw.2_Missense_Mutation_p.R571G	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	571	CPSase (Carbamoyl-phosphate synthase).|CPSase A.|ATP-grasp 1.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	TGCCTCTAACAGGGAGGAGCT	0.597													0	0	0	0.00361	0	42	18										G	27448663	A	G	27448663	3	3	121	1	0	0	0	0	1	0	0	0	2565	179	7	5	1757	5	CAD	2	27448663	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	860905	27448663	215750710	61	36096										
SLC30A3	7781	broad.mit.edu	37	chr2	27480167	27480167	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccagcggtgcatactctgctCccctagacccgtggctgtgg	12	15	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:27480167C>T	uc002rjk.2	-	5	818	c.632G>A	c.(631-633)GGA>GAA	p.G211E	SLC30A3_uc002rjj.2_Missense_Mutation_p.E57K|SLC30A3_uc010ylh.1_Missense_Mutation_p.G206E	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	211	Cytoplasmic (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATACTCTGCTCCCCTAGACCC	0.677													0	0	0	0.001168	0	4	11										T	27480167	C	T	27480167	3	4	121	1	0	0	0	0	1	0	0	0	14556	855	30	1	550	1	SLC30A3	2	27480167	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	31504	27480167	215719206	62	36097										
ZNF512	84450	broad.mit.edu	37	chr2	27821096	27821096	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgaagatgagaagaatcaaGccagctgctacttctcatgt	9	8	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:27821096G>A	uc002rla.2	+	3	339	c.252G>A	c.(250-252)AAG>AAA	p.K84K	ZNF512_uc010ylv.1_Silent_p.K5K|ZNF512_uc010ylw.1_Silent_p.K83K|ZNF512_uc002rlb.2_Silent_p.K5K|ZNF512_uc010ylx.1_Silent_p.K5K|ZNF512_uc002rlc.2_Silent_p.K5K|ZNF512_uc010yly.1_RNA|ZNF512_uc010ylz.1_Silent_p.K5K	NM_032434	NP_115810	Q96ME7	ZN512_HUMAN	zinc finger protein 512	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GAAGAATCAAGCCAGCTGCTA	0.408													0	0	0	0.002299	0	16	68										A	27821096	G	A	27821096	2	1	121	1	0	0	0	0	0	0	0	1	17953	962	34	2		2	ZNF512	2	27821096	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	340929	27821096	215378277	63	36098										
LTBP1	4052	broad.mit.edu	37	chr2	33589420	33589420	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtatacgaccggctgagtcaAacggtatgtttccaggagat	12	8	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:33589420A>G	uc002ros.2	+	30	4540	c.4540A>G	c.(4540-4542)AAC>GAC	p.N1514D	LTBP1_uc002rot.2_Missense_Mutation_p.N1188D|LTBP1_uc002rou.2_Missense_Mutation_p.N1187D|LTBP1_uc002rov.2_Missense_Mutation_p.N1134D|LTBP1_uc010ymz.1_Missense_Mutation_p.N1145D|LTBP1_uc010yna.1_Missense_Mutation_p.N1092D|LTBP1_uc010ynb.1_Missense_Mutation_p.N411D	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1513					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GGCTGAGTCAAACGGTATGTT	0.398													0	0	0	0.00499	0	14	7										G	33589420	A	G	33589420	3	3	121	1	0	0	0	0	1	0	0	0	9073	14	1	5	4710	5	LTBP1	2	33589420	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	5768324	33589420	209609953	64	36099										
EML4	27436	broad.mit.edu	37	chr2	42552634	42552634	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccagctacatcacacaccttGactggtccccagacaacaag	6	16	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:42552634G>C	uc002rsi.2	+	20	2444	c.2182G>C	c.(2182-2184)GAC>CAC	p.D728H	EML4_uc010fap.2_Missense_Mutation_p.D670H|EML4_uc002rsj.2_Missense_Mutation_p.D417H|EML4_uc010faq.2_Missense_Mutation_p.D73H|EML4_uc010ynv.1_5'UTR	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	728	WD 8.				microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						CACACACCTTGACTGGTCCCC	0.313			T	ALK	NSCLC								0	0	0	0.000602	0	3	10										C	42552634	G	C	42552634	3	2	121	1	0	0	0	0	1	0	0	0	5099	1290	45	1	2260	1	EML4	2	42552634	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8963214	42552634	200646739	65	36100										
C2orf63	130162	broad.mit.edu	37	chr2	55444968	55444968	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgcttcaagttggattgttCttttcctgtaatataccaaa	6	7	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:55444968C>G	uc002ryi.2	-	4	690	c.344G>C	c.(343-345)AGA>ACA	p.R115T	C2orf63_uc002ryh.2_Intron|C2orf63_uc002ryj.2_5'UTR	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	115							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)			TTGGATTGTTCTTTTCCTGTA	0.358													0	0	0	0.001168	0	4	15										G	55444968	C	G	55444968	3	3	121	1	0	0	0	0	1	0	0	0	2182	913	32	1	1456	1	C2orf63	2	55444968	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	12892334	55444968	187754405	66	36101										
USP34	9736	broad.mit.edu	37	chr2	61416073	61416073	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttctttctttggcttcttgCtcttggagtgagtttctctg	9	8	5	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:61416073C>T	uc002sbe.2	-	79	10027	c.10005G>A	c.(10003-10005)GAG>GAA	p.E3335E	USP34_uc002sbd.2_Silent_p.E137E	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3335					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TGGCTTCTTGCTCTTGGAGTG	0.413													0	0	0	0.012213	0	28	21										T	61416073	C	T	61416073	2	4	121	1	0	0	0	0	0	0	0	1	17062	796	28	2		2	USP34	2	61416073	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5971105	61416073	181783300	67	36102										
ATP6V1B1	525	broad.mit.edu	37	chr2	71191936	71191936	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggggaggaggcgctcacctCtgaggacctgctctacctgg	15	12	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:71191936C>A	uc002shj.2	+	13	1406	c.1319C>A	c.(1318-1320)TCT>TAT	p.S440Y	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.S423Y|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.S398Y	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	440					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GCGCTCACCTCTGAGGACCTG	0.597											OREG0014686	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.16721e-17	0.010818	9.15717e-17	25	24										A	71191936	C	A	71191936	3	1	121	1	0	0	0	0	1	0	0	0	1178	913	32	3	1369	3	ATP6V1B1	2	71191936	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9775863	71191936	172007437	68	36103										
LRRTM4	80059	broad.mit.edu	37	chr2	77745525	77745525	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccatggtctcagagtttgtAggcttgtagtccacataata	9	8	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:77745525A>T	uc002snr.2	-	3	1885	c.1470T>A	c.(1468-1470)CCT>CCA	p.P490P	LRRTM4_uc002snq.2_Silent_p.P490P|LRRTM4_uc002sns.2_Silent_p.P490P|LRRTM4_uc002snt.2_Silent_p.P491P	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	490	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CAGAGTTTGTAGGCTTGTAGT	0.468													0	0	0	0.003755	0	27	15										T	77745525	A	T	77745525	2	4	121	1	0	0	0	0	0	0	0	1	9042	407	15	5		5	LRRTM4	2	77745525	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	6553589	77745525	165453848	69	36104										
LRRTM4	80059	broad.mit.edu	37	chr2	77746266	77746266	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catgtcaaaccttggctaatGgagcgaatcctgttccattg	9	10	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:77746266G>A	uc002snr.2	-	3	1144	c.729C>T	c.(727-729)TCC>TCT	p.S243S	LRRTM4_uc002snq.2_Silent_p.S243S|LRRTM4_uc002sns.2_Silent_p.S243S|LRRTM4_uc002snt.2_Silent_p.S244S	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	243	LRR 8.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTTGGCTAATGGAGCGAATCC	0.448													0	0	0	0.004007	0	14	25										A	77746266	G	A	77746266	2	1	121	1	0	0	0	0	0	0	0	1	9042	1335	47	2		2	LRRTM4	2	77746266	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	741	77746266	165453107	70	36105										
SMYD1	150572	broad.mit.edu	37	chr2	88405960	88405960	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtcctttcctacctccaggcCtttgaggaggcctcgttcta	9	14	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:88405960C>A	uc002ssr.2	+	8	1100	c.1098C>A	c.(1096-1098)GCC>GCA	p.A366A	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Silent_p.A62A	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						ACCTCCAGGCCTTTGAGGAGG	0.522													1	0	8.16721e-17	0.010818	9.15717e-17	26	39										A	88405960	C	A	88405960	2	1	121	1	0	0	0	0	0	0	0	1	14821	668	24	4		4	SMYD1	2	88405960	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	10659694	88405960	154793413	71	36106										
CNGA3	1261	broad.mit.edu	37	chr2	98996644	98996644	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgtcaccttccaggctgtcGcgcctcatcttcttgctgcg	10	15	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:98996644G>A	uc002syt.2	+	4	639	c.222G>A	c.(220-222)TCG>TCA	p.S74S	CNGA3_uc002syu.2_Silent_p.S74S|CNGA3_uc010fij.2_Silent_p.S78S	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	74					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						CCAGGCTGTCGCGCCTCATCT	0.527													0	0	0	0.010504	0	14	20										A	98996644	G	A	98996644	2	1	121	1	0	0	0	0	0	0	0	1	3598	1074	38	2		2	CNGA3	2	98996644	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	10590684	98996644	144202729	72	36107										
BUB1	699	broad.mit.edu	37	chr2	111423892	111423892	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catgggatgtctccaccaccTgatgcaacttcttatgaagt	8	11	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:111423892T>G	uc002tgc.2	-	9	1017	c.905A>C	c.(904-906)CAG>CCG	p.Q302P	BUB1_uc010yxh.1_Missense_Mutation_p.Q282P|BUB1_uc010fkb.2_Missense_Mutation_p.Q302P|BUB1_uc002tgd.2_Missense_Mutation_p.Q302P	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	302					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		CTCCACCACCTGATGCAACTT	0.443													0	0	0	0.008871	0	18	19										G	111423892	T	G	111423892	3	3	121	1	0	0	0	0	1	0	0	0	1570	1580	55	5	2420	5	BUB1	2	111423892	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	12427248	111423892	131775481	73	36108										
SLC20A1	6574	broad.mit.edu	37	chr2	113420544	113420544	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtttgtcacagtccccatttCtggagttatcagtgctgcca	9	11	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:113420544C>G	uc002tib.2	+	11	2428	c.1982C>G	c.(1981-1983)TCT>TGT	p.S661C		NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	661	Helical; (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2						GTCCCCATTTCTGGAGTTATC	0.458													0	0	0	0.00361	0	73	59										G	113420544	C	G	113420544	3	3	121	1	0	0	0	0	1	0	0	0	14438	913	32	1	2020	1	SLC20A1	2	113420544	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1996652	113420544	129778829	74	36109										
PTPN4	5775	broad.mit.edu	37	chr2	120639722	120639722	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttttagcttcatttgctgttCagtgtaagtatcagcccatt	7	8	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:120639722C>G	uc002tmf.1	+	7	1234	c.463C>G	c.(463-465)CAG>GAG	p.Q155E	PTPN4_uc010flj.1_5'UTR	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	155	FERM.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	ATTTGCTGTTCAGTGTAAGTA	0.358													0	0	0	0.00361	0	58	44										G	120639722	C	G	120639722	3	3	121	1	0	0	0	0	1	0	0	0	12790	827	29	1	485	1	PTPN4	2	120639722	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7219178	120639722	122559651	75	36110										
GLI2	2736	broad.mit.edu	37	chr2	121747231	121747231	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgagcccccatgcctgctaTggccaagtccacccccagct	8	18	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:121747231T>C	uc010flp.2	+	13	3771	c.3741T>C	c.(3739-3741)TAT>TAC	p.Y1247Y	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.Y919Y|GLI2_uc002tmu.3_Silent_p.Y902Y	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1247					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				ATGCCTGCTATGGCCAAGTCC	0.622													0	0	0	0.010771	0	37	24										C	121747231	T	C	121747231	2	2	121	1	0	0	0	0	0	0	0	1	6438	1471	51	5		5	GLI2	2	121747231	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	1107509	121747231	121452142	76	36111										
POTEF	728378	broad.mit.edu	37	chr2	130872849	130872849	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgacatcgtctgtccagcaGgagttttactacttctgaat	8	9	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:130872849G>A	uc010fmh.2	-	4	974	c.574C>T	c.(574-576)CTG>TTG	p.L192L		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	192	ANK 1.					cell cortex	ATP binding			skin(3)|ovary(2)	5						CTGTCCAGCAGGAGTTTTACT	0.428													0	0	0	0.00361	0	26	81										A	130872849	G	A	130872849	2	1	121	1	0	0	0	0	0	0	0	1	12265	991	35	2		2	POTEF	2	130872849	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	9125618	130872849	112326524	77	36112										
RIF1	55183	broad.mit.edu	37	chr2	152330584	152330584	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgatgaagaaagacttgtctCaggtatattttagcaaaagt	9	4	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:152330584C>G	uc002txm.2	+	35	7332	c.7202C>G	c.(7201-7203)TCA>TGA	p.S2401*	RIF1_uc002txl.2_Nonsense_Mutation_p.S2375*|RIF1_uc002txn.2_Nonsense_Mutation_p.S2375*|RIF1_uc002txo.2_Nonsense_Mutation_p.S2375*|RIF1_uc002txp.2_RNA|uc010fnw.1_5'Flank	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	2401	Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AGACTTGTCTCAGGTATATTT	0.299													0	0	0	0.007835	0	32	26										G	152330584	C	G	152330584	4	3	121	1	0	0	0	0	0	1	0	0	13359	838	29	1	7336	1	RIF1	2	152330584	Nonsense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	21457735	152330584	90868789	78	36113										
BAZ2B	29994	broad.mit.edu	37	chr2	160252303	160252303	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcttttttacgagcttccaTagctttcataagcatcatgt	6	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:160252303T>C	uc002uao.2	-	20	3404	c.3052A>G	c.(3052-3054)ATG>GTG	p.M1018V	BAZ2B_uc002uap.2_Missense_Mutation_p.M982V	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1018	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CGAGCTTCCATAGCTTTCATA	0.338													0	0	0	0.00308	0	5	12										C	160252303	T	C	160252303	3	2	121	1	0	0	0	0	1	0	0	0	1332	1406	49	5	3526	5	BAZ2B	2	160252303	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	7921719	160252303	82947070	79	36114										
FAP	2191	broad.mit.edu	37	chr2	163051256	163051256	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggtggaaatggggatgcctgGgcctgtgggcaggatgaaaa	19	5	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:163051256G>A	uc002ucd.2	-	17	1613	c.1405C>T	c.(1405-1407)CCA>TCA	p.P469S	FAP_uc010fpc.2_Missense_Mutation_p.P18S|FAP_uc010zct.1_Missense_Mutation_p.P444S|FAP_uc010fpd.2_5'UTR	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	469	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GGGATGCCTGGGCCTGTGGGC	0.438													0	0	0	0.007413	0	14	49										A	163051256	G	A	163051256	3	1	121	1	0	0	0	0	1	0	0	0	5673	1232	43	2	917	2	FAP	2	163051256	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2798953	163051256	80148117	80	36115										
GCA	25801	broad.mit.edu	37	chr2	163213345	163213345	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatgcctggaaggaaaacttCatgactgttgatcaagatgg	11	6	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:163213345C>T	uc002ucg.2	+	5	560	c.384C>T	c.(382-384)TTC>TTT	p.F128F	GCA_uc010zcu.1_Silent_p.F109F	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	128	EF-hand 3.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						AGGAAAACTTCATGACTGTTG	0.368													0	0	0	0.00361	0	46	22										T	163213345	C	T	163213345	2	4	121	1	0	0	0	0	0	0	0	1	6283	825	29	1		1	GCA	2	163213345	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	162089	163213345	79986028	81	36116										
SCN2A	6326	broad.mit.edu	37	chr2	166245291	166245291	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctttgatgatgtcccttcctGcgttgtttaacatcggcctc	8	12	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:166245291G>C	uc002udc.2	+	27	5265	c.4975G>C	c.(4975-4977)GCG>CCG	p.A1659P	SCN2A_uc002udd.2_Missense_Mutation_p.A1659P|SCN2A_uc002ude.2_Missense_Mutation_p.A1659P	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1659	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	GTCCCTTCCTGCGTTGTTTAA	0.498													0	0	0	0.001855	0	13	94										C	166245291	G	C	166245291	3	2	121	1	0	0	0	0	1	0	0	0	13916	1319	46	4	5173	4	SCN2A	2	166245291	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3031946	166245291	76954082	82	36117										
SCN2A	6326	broad.mit.edu	37	chr2	166246148	166246148	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaagaatgtgatggaacaccCatcaaagaagatactctcat	7	8	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:166246148C>A	uc002udc.2	+	27	6122	c.5832C>A	c.(5830-5832)CCC>CCA	p.P1944P	SCN2A_uc002udd.2_Silent_p.P1944P|SCN2A_uc002ude.2_Silent_p.P1944P	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1944					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ATGGAACACCCATCAAAGAAG	0.403													1	0	5.2432e-18	0.00361	5.9186e-18	35	13										A	166246148	C	A	166246148	2	1	121	1	0	0	0	0	0	0	0	1	13916	581	21	4		4	SCN2A	2	166246148	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	857	166246148	76953225	83	36118										
SCN1A	6323	broad.mit.edu	37	chr2	166859238	166859238	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cattcatgatggatggaattGctcctaaaagggcattcaca	9	8	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:166859238G>T	uc010zcz.1	-	21	4013	c.3995C>A	c.(3994-3996)GCA>GAA	p.A1332E	SCN1A_uc002udo.3_Missense_Mutation_p.A1212E|SCN1A_uc010fpk.2_Missense_Mutation_p.A1184E	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1343	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGATGGAATTGCTCCTAAAAG	0.348													1	0	5.73237e-09	0.00623	6.05993e-09	28	14										T	166859238	G	T	166859238	3	4	121	1	0	0	0	0	1	0	0	0	13914	1319	46	4	2025	4	SCN1A	2	166859238	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	613090	166859238	76340135	84	36119										
STK39	27347	broad.mit.edu	37	chr2	169020276	169020276	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctgaccgtttctgtgtagaTagtctaagccttccaaaacc	7	11	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:169020276T>C	uc002uea.2	-	4	705	c.545A>G	c.(544-546)TAT>TGT	p.Y182C		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	182	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						TCTGTGTAGATAGTCTAAGCC	0.378													0	0	0	0.009096	0	4	35										C	169020276	T	C	169020276	3	2	121	1	0	0	0	0	1	0	0	0	15304	1406	49	5	1152	5	STK39	2	169020276	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2161038	169020276	74179097	85	36120										
LRP2	4036	broad.mit.edu	37	chr2	170060728	170060728	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caaaagcatgaacggctgcaTtgacaatgacttcacgatcc	8	11	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:170060728T>A	uc002ues.2	-	42	7982	c.7769A>T	c.(7768-7770)AAT>ATT	p.N2590I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2590	LDL-receptor class B 28.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AACGGCTGCATTGACAATGAC	0.418													0	0	0	0.00361	0	167	101										A	170060728	T	A	170060728	3	1	121	1	0	0	0	0	1	0	0	0	8956	1493	52	5	6350	5	LRP2	2	170060728	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	1040452	170060728	73138645	86	36121										
PDE11A	50940	broad.mit.edu	37	chr2	178684974	178684974	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttggtggttgctattccaaaTagggacacaaagaacagatc	10	7	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:178684974T>C	uc002ulq.2	-	7	1867	c.1549A>G	c.(1549-1551)ATT>GTT	p.I517V	PDE11A_uc002ulp.2_Missense_Mutation_p.I73V|PDE11A_uc002ulr.2_Missense_Mutation_p.I267V|PDE11A_uc002uls.1_Missense_Mutation_p.I159V|PDE11A_uc002ult.1_Missense_Mutation_p.I267V|PDE11A_uc002ulu.1_Missense_Mutation_p.I159V	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	517	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CTATTCCAAATAGGGACACAA	0.294									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.010771	0	29	16										C	178684974	T	C	178684974	3	2	121	1	0	0	0	0	1	0	0	0	11631	1406	49	5	1308	5	PDE11A	2	178684974	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	8624246	178684974	64514399	87	36122										
TTN	7273	broad.mit.edu	37	chr2	179396043	179396043	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cacttttcatttctgcagatGcagagtgttcatatgaggag	10	7	3	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:179396043G>A	uc010zfg.1	-	307	97819	c.97595C>T	c.(97594-97596)GCA>GTA	p.A32532V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A26227V|TTN_uc010zfi.1_Missense_Mutation_p.A26160V|TTN_uc010zfj.1_Missense_Mutation_p.A26035V|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33459							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGCAGATGCAGAGTGTTC	0.408													0	0	0	0.004878	0	32	10										A	179396043	G	A	179396043	3	1	121	1	0	0	0	0	1	0	0	0	16732	1319	46	2	2700	2	TTN	2	179396043	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	711069	179396043	63803330	88	36123										
TTN	7273	broad.mit.edu	37	chr2	179428076	179428076	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggtgcgccaccatcataaaTtggcttactccatgccaggg	10	12	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:179428076T>A	uc010zfg.1	-	275	75303	c.75079A>T	c.(75079-75081)ATT>TTT	p.I25027F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I18722F|TTN_uc010zfi.1_Missense_Mutation_p.I18655F|TTN_uc010zfj.1_Missense_Mutation_p.I18530F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25954							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATCATAAATTGGCTTACTC	0.507													0	0	0	0.001368	0	10	22										A	179428076	T	A	179428076	3	1	121	1	0	0	0	0	1	0	0	0	16732	1493	52	5	25344	5	TTN	2	179428076	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	32033	179428076	63771297	89	36124										
TTN	7273	broad.mit.edu	37	chr2	179431369	179431369	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgaatttttagtggtgtctAcaatgtgtgcattggtaggt	12	3	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:179431369A>G	uc010zfg.1	-	275	72010	c.71786T>C	c.(71785-71787)GTA>GCA	p.V23929A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V17624A|TTN_uc010zfi.1_Missense_Mutation_p.V17557A|TTN_uc010zfj.1_Missense_Mutation_p.V17432A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24856							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGGTGTCTACAATGTGTGC	0.443													0	0	0	0.00361	0	57	165										G	179431369	A	G	179431369	3	3	121	1	0	0	0	0	1	0	0	0	16732	391	14	5	28637	5	TTN	2	179431369	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	3293	179431369	63768004	90	36125										
TTN	7273	broad.mit.edu	37	chr2	179440159	179440159	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttctttgggcttcaatcacaTagccagtgatcttgctgcca	8	11	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:179440159T>C	uc010zfg.1	-	275	63220	c.62996A>G	c.(62995-62997)TAT>TGT	p.Y20999C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y14694C|TTN_uc010zfi.1_Missense_Mutation_p.Y14627C|TTN_uc010zfj.1_Missense_Mutation_p.Y14502C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21926							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAATCACATAGCCAGTGAT	0.493													0	0	0	0.002299	0	20	40										C	179440159	T	C	179440159	3	2	121	1	0	0	0	0	1	0	0	0	16732	1406	49	5	37427	5	TTN	2	179440159	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	8790	179440159	63759214	91	36126										
TTN	7273	broad.mit.edu	37	chr2	179621183	179621183	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaggaattgagccgtgtcacCgcactttacagtgacgtcct	11	11	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:179621183C>T	uc010zfh.1	-	44	10731	c.10507G>A	c.(10507-10509)GGT>AGT	p.G3503S	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	3517							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCGTGTCACCGCACTTTACA	0.453													0	0	0	0.00333	0	22	8										T	179621183	C	T	179621183	3	4	121	1	0	0	0	0	1	0	0	0	16732	652	23	2	100236	2	TTN	2	179621183	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	181024	179621183	63578190	92	36127										
HECW2	57520	broad.mit.edu	37	chr2	197183282	197183282	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgtccatatcctacctccagTagcgccctcctcctgggcag	8	17	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:197183282T>A	uc002utm.1	-	9	2515	c.2332A>T	c.(2332-2334)ACT>TCT	p.T778S	HECW2_uc002utl.1_Missense_Mutation_p.T422S	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	778	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CTACCTCCAGTAGCGCCCTCC	0.592													0	0	0	0.007291	0	24	19										A	197183282	T	A	197183282	3	1	121	1	0	0	0	0	1	0	0	0	7043	1638	57	5	2470	5	HECW2	2	197183282	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	17562099	197183282	46016091	93	36128										
HSPE1	3336	broad.mit.edu	37	chr2	198367982	198367982	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcttggaaagtacgtagactGaaataagtcactattgaaat	8	5	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:198367982G>A	uc002uul.2	+	4	748	c.308G>A	c.(307-309)TGA>TAA	p.*103*	HSPD1_uc002uuk.2_5'Flank	NM_002157	NP_002148	P61604	CH10_HUMAN	heat shock 10kDa protein 1	103					activation of caspase activity|protein folding|response to unfolded protein	mitochondrial matrix	ATP binding|chaperone binding|unfolded protein binding				0			Epithelial(96;0.225)			TACGTAGACTGAAATAAGTCA	0.328													0	0	0	0.00361	0	38	9										A	198367982	G	A	198367982	2	1	121	1	0	0	0	0	0	0	0	1	7429	1285	45	1		1	HSPE1	2	198367982	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1184700	198367982	44831391	94	36129										
ADAM23	8745	broad.mit.edu	37	chr2	207459510	207459510	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cggatgtgggctatgtagaaGatggaacgccatgtggcccg	16	8	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:207459510G>C	uc002vbq.2	+	23	2351	c.2128G>C	c.(2128-2130)GAT>CAT	p.D710H	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	710	Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		CTATGTAGAAGATGGAACGCC	0.428													0	0	0	0.00361	0	42	25										C	207459510	G	C	207459510	3	2	121	1	0	0	0	0	1	0	0	0	245	942	33	1	2218	1	ADAM23	2	207459510	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	9091528	207459510	35739863	95	36130										
USP37	57695	broad.mit.edu	37	chr2	219324581	219324581	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atcaaaaacatcctcatttcCagagtcctcatcagaaccca	3	14	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:219324581C>G	uc002vie.2	-	23	3028	c.2575G>C	c.(2575-2577)GGA>CGA	p.G859R	USP37_uc010fvs.1_Missense_Mutation_p.G859R|USP37_uc010zkf.1_Missense_Mutation_p.G859R|USP37_uc002vif.2_Missense_Mutation_p.G859R|USP37_uc002vig.2_Missense_Mutation_p.G765R	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	859					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TCCTCATTTCCAGAGTCCTCA	0.358													0	0	0	0.00361	0	60	3										G	219324581	C	G	219324581	3	3	121	1	0	0	0	0	1	0	0	0	17065	603	21	4	380	4	USP37	2	219324581	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	11865071	219324581	23874792	96	36131										
PAX3	5077	broad.mit.edu	37	chr2	223086063	223086063	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagccatcagttgattggccCcagcttgcttcctccatctt	7	14	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:223086063C>T	uc010fwo.2	-	6	1202	c.836G>A	c.(835-837)GGG>GAG	p.G279E	PAX3_uc002vmt.1_Missense_Mutation_p.G279E|PAX3_uc002vmy.1_Missense_Mutation_p.G278E|PAX3_uc002vmv.1_Missense_Mutation_p.G279E|PAX3_uc002vmw.1_Missense_Mutation_p.G279E|PAX3_uc002vmx.1_Missense_Mutation_p.G279E	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	279					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGATTGGCCCCAGCTTGCTT	0.473			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						0	0	0	0.00361	0	74	5										T	223086063	C	T	223086063	3	4	121	1	0	0	0	0	1	0	0	0	11480	623	22	2	729	2	PAX3	2	223086063	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3761482	223086063	20113310	97	36132										
WDR69	164781	broad.mit.edu	37	chr2	228758558	228758558	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgcaagctctgggacactgCgtctggagaggagctgaaca	15	9	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:228758558C>T	uc002vpn.1	+	5	444	c.365C>T	c.(364-366)GCG>GTG	p.A122V	WDR69_uc010zlw.1_Missense_Mutation_p.A107V|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	122	WD 1.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TGGGACACTGCGTCTGGAGAG	0.433													0	0	0	0.00308	0	7	2										T	228758558	C	T	228758558	3	4	121	1	0	0	0	0	1	0	0	0	17316	768	27	2	383	2	WDR69	2	228758558	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5672495	228758558	14440815	98	36133										
PSMD1	5707	broad.mit.edu	37	chr2	231927368	231927368	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcaatgtcaatgataactctGaatatgtggaaactattata	6	5	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr2:231927368G>A	uc002vrn.1	+	4	414	c.283G>A	c.(283-285)GAA>AAA	p.E95K	PSMD1_uc002vrm.1_Missense_Mutation_p.E95K|PSMD1_uc010fxu.1_Intron	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	95					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	TGATAACTCTGAATATGTGGA	0.398													0	0	0	0.003954	0	20	3										A	231927368	G	A	231927368	3	1	121	1	0	0	0	0	1	0	0	0	12692	1291	45	1	297	1	PSMD1	2	231927368	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3168810	231927368	11272005	99	36134										
SNRK	54861	broad.mit.edu	37	chr3	43384866	43384866	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accaacaggtataaccatatCacagccacatacttcctgct	4	14	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:43384866C>G	uc003cms.3	+	6	1307	c.975C>G	c.(973-975)ATC>ATG	p.I325M	SNRK_uc003cmt.3_Missense_Mutation_p.I325M|SNRK_uc010hik.2_Missense_Mutation_p.I325M|SNRK_uc011azr.1_Missense_Mutation_p.I119M	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	325	UBA.				myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		ATAACCATATCACAGCCACAT	0.448													0	0	0	0.009096	0	3	87										G	43384866	C	G	43384866	3	3	121	1	0	0	0	0	1	0	0	0	14851	816	29	1	989	1	SNRK	3	43384866	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		43384866	154637564	100	36135										
TMIE	259236	broad.mit.edu	37	chr3	46751086	46751086	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagaggataagaagaagaagAagaagaagaagaaggacagt	14	2	0	9			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:46751086A>C	uc010hjk.1	+	4	534	c.379A>C	c.(379-381)AAG>CAG	p.K127Q	TMIE_uc010hjj.1_3'UTR	NM_147196	NP_671729	Q8NEW7	TMIE_HUMAN	transmembrane inner ear protein precursor	127	Cytoplasmic (Potential).|Lys-rich.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000688)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		gaagaagaagaagaagaagaa	0.458													0	0	0	0.008871	0	19	28										C	46751086	A	C	46751086	3	2	121	1	0	0	0	0	1	0	0	0	16226	247	9	5	393	5	TMIE	3	46751086	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	3366220	46751086	151271344	101	36136										
CELSR3	1951	broad.mit.edu	37	chr3	48699092	48699092	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgtctggtagttgtactgcgGaaactgcgggtggcggtttg	17	7	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:48699092G>A	uc003cul.2	-	1	1257	c.976C>T	c.(976-978)CCG>TCG	p.P326S	CELSR3_uc003cuf.1_Missense_Mutation_p.P396S	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	326	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TTGTACTGCGGAAACTGCGGG	0.701													0	0	0	0.009535	0	25	80										A	48699092	G	A	48699092	3	1	121	1	0	0	0	0	1	0	0	0	3223	1174	41	1	9102	1	CELSR3	3	48699092	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1948006	48699092	149323338	102	36137										
BSN	8927	broad.mit.edu	37	chr3	49689154	49689154	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gccacatccacccagcccctCcgagatccacaaggtgggga	10	17	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:49689154C>T	uc003cxe.3	+	5	2279	c.2165C>T	c.(2164-2166)TCC>TTC	p.S722F		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	722					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCCAGCCCCTCCGAGATCCAC	0.647													0	0	0	0.00361	0	62	30										T	49689154	C	T	49689154	3	4	121	1	0	0	0	0	1	0	0	0	1530	855	30	1	2183	1	BSN	3	49689154	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	990062	49689154	148333276	103	36138										
GRM2	2912	broad.mit.edu	37	chr3	51746972	51746972	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caggcagtgagggggctgctGagggtgctatcaccatcgag	17	9	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:51746972G>A	uc010hlv.2	+	3	1173	c.934G>A	c.(934-936)GAG>AAG	p.E312K	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	312	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGGGGCTGCTGAGGGTGCTAT	0.627													0	0	0	0.00361	0	39	23										A	51746972	G	A	51746972	3	1	121	1	0	0	0	0	1	0	0	0	6797	1291	45	1	940	1	GRM2	3	51746972	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2057818	51746972	146275458	104	36139										
UBA3	9039	broad.mit.edu	37	chr3	69113226	69113226	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtaaaaaacttacgtcgataGaaagtgtcgttaaaatcttg	8	5	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:69113226G>A	uc003dno.2	-	7	485	c.465C>T	c.(463-465)TTC>TTT	p.F155F	UBA3_uc003dnq.2_Silent_p.F141F|UBA3_uc011bfy.1_Intron|UBA3_uc011bfz.1_Intron	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	155	ATP.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		TACGTCGATAGAAAGTGTCGT	0.289													0	0	0	0.006214	0	6	7										A	69113226	G	A	69113226	2	1	121	1	0	0	0	0	0	0	0	1	16826	933	33	1		1	UBA3	3	69113226	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	17366254	69113226	128909204	105	36140										
ROBO2	6092	broad.mit.edu	37	chr3	77607281	77607281	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aattcaagagcaaggcacacTgcagattaagaatttacggg	10	7	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:77607281T>C	uc003dpy.3	+	9	2061	c.1418T>C	c.(1417-1419)CTG>CCG	p.L473P	ROBO2_uc003dpz.2_Missense_Mutation_p.L477P|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.L477P	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	473	Ig-like C2-type 5.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAAGGCACACTGCAGATTAAG	0.378													0	0	0	0.00361	0	55	24										C	77607281	T	C	77607281	3	2	121	1	0	0	0	0	1	0	0	0	13514	1580	55	5	1454	5	ROBO2	3	77607281	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	8494055	77607281	120415149	106	36141										
ROBO2	6092	broad.mit.edu	37	chr3	77626765	77626765	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggaattatccaagaatacaaGgtaggacccgggtgaagaag	13	6	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:77626765G>T	uc003dpy.3	+	15	2971	c.2328G>T	c.(2326-2328)AAG>AAT	p.K776N	ROBO2_uc003dpz.2_Missense_Mutation_p.K780N|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.K780N	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	776	Fibronectin type-III 3.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AAGAATACAAGGTAGGACCCG	0.443													1	0	6.00712e-18	0.012213	6.76945e-18	25	14										T	77626765	G	T	77626765	3	4	121	1	0	0	0	0	1	0	0	0	13514	1014	35	4	2388	4	ROBO2	3	77626765	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	19484	77626765	120395665	107	36142										
EPHA6	285220	broad.mit.edu	37	chr3	97311498	97311498	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggaggcgttttgccccagctTcctgagggcagggtttttaa	14	9	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:97311498T>A	uc010how.1	+	12	2472	c.2429T>A	c.(2428-2430)TTC>TAC	p.F810Y	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.F176Y|EPHA6_uc003drs.3_Missense_Mutation_p.F202Y|EPHA6_uc003drr.3_Missense_Mutation_p.F202Y|EPHA6_uc003drt.2_Missense_Mutation_p.F202Y|EPHA6_uc010hox.1_Intron	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	715	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TGCCCCAGCTTCCTGAGGGCA	0.493													0	0	0	0.00245	0	11	23										A	97311498	T	A	97311498	3	1	121	1	0	0	0	0	1	0	0	0	5171	1783	62	5	2543	5	EPHA6	3	97311498	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	19684733	97311498	100710932	108	36143										
CD200	4345	broad.mit.edu	37	chr3	112059796	112059796	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctacctacagcctggtttgGgtcatggcagcagtggtgct	13	10	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:112059796G>A	uc003dyw.2	+	3	279	c.135G>A	c.(133-135)TGG>TGA	p.W45*	CD200_uc010hqd.1_5'UTR|CD200_uc003dyx.2_Nonsense_Mutation_p.W20*|CD200_uc003dyy.2_Intron|CD200_uc003dyz.2_Intron	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	20					regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				GCCTGGTTTGGGTCATGGCAG	0.483													0	0	0	0.005443	0	16	57										A	112059796	G	A	112059796	4	1	121	1	0	0	0	0	0	1	0	0	2980	1241	43	2	145	2	CD200	3	112059796	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	14748298	112059796	85962634	109	36144										
CCDC52	152185	broad.mit.edu	37	chr3	113188079	113188079	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttctcttctgttagttgttgGagaaacctataaattacagg	8	6	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:113188079G>C	uc003eag.3	-	8	909	c.618C>G	c.(616-618)CTC>CTG	p.L206L	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Silent_p.L102L	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	206					cell division|mitosis	centriole|spindle	protein binding				0						TTAGTTGTTGGAGAAACCTAT	0.259													0	0	0	0.007413	0	16	6										C	113188079	G	C	113188079	2	2	121	1	0	0	0	0	0	0	0	1	2822	1161	41	1		1	CCDC52	3	113188079	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1128283	113188079	84834351	110	36145										
KIAA2018	205717	broad.mit.edu	37	chr3	113376934	113376934	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agttgcttcaattgaaccctGagaattaaattcatttggtg	8	6	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:113376934G>A	uc003eam.2	-	7	4006	c.3595C>T	c.(3595-3597)CAG>TAG	p.Q1199*	KIAA2018_uc003eal.2_Nonsense_Mutation_p.Q1143*	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1199					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						ATTGAACCCTGAGAATTAAAT	0.413													0	0	0	0.00333	0	21	17										A	113376934	G	A	113376934	4	1	121	1	0	0	0	0	0	1	0	0	8268	1299	45	1	3146	1	KIAA2018	3	113376934	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	188855	113376934	84645496	111	36146										
ZBTB20	26137	broad.mit.edu	37	chr3	114070467	114070467	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgtacatgaagtcaatgagcTtttgcactgactgcactgac	9	9	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:114070467T>C	uc003ebi.2	-	4	638	c.458A>G	c.(457-459)AAG>AGG	p.K153R	ZBTB20_uc003ebj.2_Missense_Mutation_p.K80R|ZBTB20_uc010hqp.2_Missense_Mutation_p.K80R|ZBTB20_uc003ebk.2_Missense_Mutation_p.K80R|ZBTB20_uc003ebl.2_Missense_Mutation_p.K80R|ZBTB20_uc003ebm.2_Missense_Mutation_p.K80R|ZBTB20_uc003ebn.2_Missense_Mutation_p.K80R|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	153	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GTCAATGAGCTTTTGCACTGA	0.582													0	0	0	0.012319	0	18	53										C	114070467	T	C	114070467	3	2	121	1	0	0	0	0	1	0	0	0	17526	1609	56	5	1775	5	ZBTB20	3	114070467	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	693533	114070467	83951963	112	36147										
KTELC1	56983	broad.mit.edu	37	chr3	119205718	119205718	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcctctcattcttctgtctcGgaaaaacccaaaacttgttg	5	12	4	0	rs117423733	by1000genomes	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:119205718G>T	uc003ecm.2	+	7	761	c.677G>T	c.(676-678)CGG>CTG	p.R226L	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Missense_Mutation_p.R67L	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	226						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		CTTCTGTCTCGGAAAAACCCA	0.413													1	0	1.88225e-35	0.00361	2.21481e-35	47	68										T	119205718	G	T	119205718	3	4	121	1	0	0	0	0	1	0	0	0	8583	1116	39	4	703	4	KTELC1	3	119205718	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5135251	119205718	78816712	113	36148										
GOLGB1	2804	broad.mit.edu	37	chr3	121410945	121410945	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttctcctcttcctcctgggaCagcaggttttccagctcttt	7	14	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:121410945C>T	uc003eei.3	-	14	7377	c.7251G>A	c.(7249-7251)CTG>CTA	p.L2417L	GOLGB1_uc010hrc.2_Silent_p.L2422L|GOLGB1_uc003eej.3_Silent_p.L2383L	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2417	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		CCTCCTGGGACAGCAGGTTTT	0.403													0	0	0	0.002836	0	29	29										T	121410945	C	T	121410945	2	4	121	1	0	0	0	0	0	0	0	1	6565	465	17	2		2	GOLGB1	3	121410945	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2205227	121410945	76611485	114	36149										
GOLGB1	2804	broad.mit.edu	37	chr3	121417379	121417379	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctttgttgatttcaattctActccagcatcatttaaagat	5	8	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:121417379A>C	uc003eei.3	-	13	2102	c.1976T>G	c.(1975-1977)GTA>GGA	p.V659G	GOLGB1_uc010hrc.2_Missense_Mutation_p.V664G|GOLGB1_uc003eej.3_Missense_Mutation_p.V625G|GOLGB1_uc011bjm.1_Missense_Mutation_p.V545G|GOLGB1_uc010hrd.1_Missense_Mutation_p.V623G	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	659	Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTCAATTCTACTCCAGCATC	0.393													0	0	0	0.001168	0	3	92										C	121417379	A	C	121417379	3	2	121	1	0	0	0	0	1	0	0	0	6565	391	14	5	7843	5	GOLGB1	3	121417379	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	6434	121417379	76605051	115	36150										
CCDC37	348807	broad.mit.edu	37	chr3	126142417	126142417	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcagaacctgtcgctgatcCagaacagccaggagacggag	13	11	0	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:126142417C>T	uc003eiu.1	+	13	1315	c.1216C>T	c.(1216-1218)CAG>TAG	p.Q406*	CCDC37_uc010hsg.1_Nonsense_Mutation_p.Q407*	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	406	Potential.									ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)		GTCGCTGATCCAGAACAGCCA	0.597													0	0	0	0.009718	0	33	39										T	126142417	C	T	126142417	4	4	121	1	0	0	0	0	0	1	0	0	2809	595	21	2	1262	2	CCDC37	3	126142417	Nonsense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	4725038	126142417	71880013	116	36151										
ABTB1	80325	broad.mit.edu	37	chr3	127391916	127391916	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcaggaagggggatgtgggCcgagtgcggtgaggacctcg	21	7	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:127391916C>T	uc003ejt.2	+	1	136	c.48C>T	c.(46-48)GGC>GGT	p.G16G	ABTB1_uc003ejr.2_5'UTR|ABTB1_uc003ejs.2_Missense_Mutation_p.A3V|ABTB1_uc003eju.2_5'Flank	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	16	ANK 1.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						GGGATGTGGGCCGAGTGCGGT	0.746													0	0	0	0.010729	0	9	19										T	127391916	C	T	127391916	2	4	121	1	0	0	0	0	0	0	0	1	102	726	26	2		2	ABTB1	3	127391916	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1249499	127391916	70630514	117	36152										
ATP2C1	27032	broad.mit.edu	37	chr3	130686221	130686221	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	attagaaacaatactctaatGgggaagccaacagaaggggc	11	7	1	2	rs115441492	by1000genomes	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:130686221G>T	uc003enl.2	+	16	1488	c.1266G>T	c.(1264-1266)ATG>ATT	p.M422I	ATP2C1_uc011blg.1_Missense_Mutation_p.M456I|ATP2C1_uc011blh.1_Missense_Mutation_p.M417I|ATP2C1_uc011bli.1_Missense_Mutation_p.M456I|ATP2C1_uc003enk.2_Missense_Mutation_p.M406I|ATP2C1_uc003enm.2_Missense_Mutation_p.M422I|ATP2C1_uc003enn.2_Missense_Mutation_p.M406I|ATP2C1_uc003eno.2_Missense_Mutation_p.M422I|ATP2C1_uc003enp.2_Missense_Mutation_p.M422I|ATP2C1_uc003enq.2_Missense_Mutation_p.M422I|ATP2C1_uc003enr.2_Missense_Mutation_p.M422I|ATP2C1_uc003ens.2_Missense_Mutation_p.M422I|ATP2C1_uc003ent.2_Missense_Mutation_p.M422I|ATP2C1_uc003enu.2_Missense_Mutation_p.M100I	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	422	Cytoplasmic (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	ATACTCTAATGGGGAAGCCAA	0.393									Hailey-Hailey_disease				1	0	1.06644e-07	0.007835	1.11675e-07	29	36										T	130686221	G	T	130686221	3	4	121	1	0	0	0	0	1	0	0	0	1143	1348	47	4	1324	4	ATP2C1	3	130686221	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3294305	130686221	67336209	118	36153										
EPHB1	2047	broad.mit.edu	37	chr3	134851706	134851706	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggcagaccgccggagctgctCccgctgtgacgacaatgtgg	15	13	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:134851706C>T	uc003eqt.2	+	5	1332	c.1112C>T	c.(1111-1113)TCC>TTC	p.S371F	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	371	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CGGAGCTGCTCCCGCTGTGAC	0.612													0	0	0	0.007835	0	29	27										T	134851706	C	T	134851706	3	4	121	1	0	0	0	0	1	0	0	0	5174	855	30	1	1130	1	EPHB1	3	134851706	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	4165485	134851706	63170724	119	36154										
STAG1	10274	broad.mit.edu	37	chr3	136085925	136085925	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttcatcttcttcatcaccctCtaaacacagattacaaattg	2	12	6	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:136085925C>G	uc003era.1	-	25	2838	c.2546_splice	c.e25-1	p.E849_splice	STAG1_uc003erb.1_Splice_Site_p.E849_splice|STAG1_uc003erc.1_Intron	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1						cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						TCATCACCCTCTAAACACAGA	0.299													0	0	0	0.012213	0	22	119										G	136085925	C	G	136085925	5	3	121	1	0	0	0	0	0	0	1	0	15241	927	32	1	1271	1	STAG1	3	136085925	Splice_Site	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1234219	136085925	61936505	120	36155										
STAG1	10274	broad.mit.edu	37	chr3	136196190	136196190	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtcatttaggaaggcatcacTatacattttcatccatactc	5	10	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:136196190T>A	uc003era.1	-	10	1259	c.967A>T	c.(967-969)AGT>TGT	p.S323C	STAG1_uc003erb.1_Missense_Mutation_p.S323C|STAG1_uc003erc.1_Missense_Mutation_p.S97C|STAG1_uc010hua.1_Missense_Mutation_p.S186C	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	323	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						AAGGCATCACTATACATTTTC	0.343													0	0	0	0.00361	0	57	29										A	136196190	T	A	136196190	3	1	121	1	0	0	0	0	1	0	0	0	15241	1522	53	5	2909	5	STAG1	3	136196190	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	110265	136196190	61826240	121	36156										
PRR23A	729627	broad.mit.edu	37	chr3	138724664	138724664	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	taggcctcttcctgggcggcGatctctgggacagatgcgca	14	12	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:138724664G>A	uc011bms.1	-	1	447	c.447C>T	c.(445-447)ATC>ATT	p.I149I		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	149											0						CCTGGGCGGCGATCTCTGGGA	0.647													0	0	0	0.00499	0	11	24										A	138724664	G	A	138724664	2	1	121	1	0	0	0	0	0	0	0	1	12594	1048	37	1		1	PRR23A	3	138724664	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2528474	138724664	59297766	122	36157										
GRK7	131890	broad.mit.edu	37	chr3	141497288	141497288	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctccgccagaagctgtccctGaacttccacagcctgtgtga	9	15	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:141497288G>A	uc011bnd.1	+	1	246	c.162G>A	c.(160-162)CTG>CTA	p.L54L		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	54					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						AGCTGTCCCTGAACTTCCACA	0.677													0	0	0	0.00278	0	20	1										A	141497288	G	A	141497288	2	1	121	1	0	0	0	0	0	0	0	1	6794	1277	45	1		1	GRK7	3	141497288	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2772624	141497288	56525142	123	36158										
PAQR9	344838	broad.mit.edu	37	chr3	142681984	142681984	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcctgggccgtgcacggcagAcgccggtagcccgacaggat	15	14	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:142681984A>T	uc003evg.2	-	1	195	c.195T>A	c.(193-195)CGT>CGA	p.R65R	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	65	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TGCACGGCAGACGCCGGTAGC	0.667													0	0	0	0.00245	0	13	4										T	142681984	A	T	142681984	2	4	121	1	0	0	0	0	0	0	0	1	11442	262	10	5		5	PAQR9	3	142681984	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1184696	142681984	55340446	124	36159										
WDR49	151790	broad.mit.edu	37	chr3	167196776	167196776	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtttttctcatcaaatacagCtttcaaagctacaaaatgat	4	8	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:167196776C>G	uc003fev.1	-	15	2290	c.1984G>C	c.(1984-1986)GCT>CCT	p.A662P	WDR49_uc003feu.1_Missense_Mutation_p.A487P|WDR49_uc011bpd.1_Missense_Mutation_p.A627P|WDR49_uc003few.1_3'UTR	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	662										large_intestine(1)|ovary(1)|skin(1)	3						TCAAATACAGCTTTCAAAGCT	0.318													0	0	0	0.004672	0	2	9										G	167196776	C	G	167196776	3	3	121	1	0	0	0	0	1	0	0	0	17299	797	28	4	113	4	WDR49	3	167196776	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	24514792	167196776	30825654	125	36160										
PLD1	5337	broad.mit.edu	37	chr3	171427487	171427487	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgtctatagctgttgcatttTaaaataagtgtcctttaaag	7	5	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:171427487T>C	uc003fhs.2	-	10	1040	c.924A>G	c.(922-924)TTA>TTG	p.L308L	PLD1_uc003fht.2_Silent_p.L308L	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	308	PH.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TGTTGCATTTTAAAATAAGTG	0.373													0	0	0	0.00361	0	39	39										C	171427487	T	C	171427487	2	2	121	1	0	0	0	0	0	0	0	1	12045	1751	61	5		5	PLD1	3	171427487	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	4230711	171427487	26594943	126	36161										
NLGN1	22871	broad.mit.edu	37	chr3	173998359	173998359	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tagcatggaccagatattccCagaaagaccaactttatctc	6	11	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr3:173998359C>A	uc003fio.1	+	7	2161	c.1738C>A	c.(1738-1740)CAG>AAG	p.Q580K	NLGN1_uc003fip.1_Missense_Mutation_p.Q580K	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	597	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CAGATATTCCCAGAAAGACCA	0.403													1	0	1.30916e-28	0.00361	1.519e-28	41	48										A	173998359	C	A	173998359	3	1	121	1	0	0	0	0	1	0	0	0	10461	595	21	4	1756	4	NLGN1	3	173998359	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2570872	173998359	24024071	127	36162										
GAK	2580	broad.mit.edu	37	chr4	860930	860930	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttgcaggcctgcgggggtaCagctggccctgcgcccacct	14	16	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:860930C>A	uc003gbm.3	-	21	2885	c.2686G>T	c.(2686-2688)GTA>TTA	p.V896L	GAK_uc003gbn.3_Missense_Mutation_p.V817L|GAK_uc010ibk.1_Missense_Mutation_p.V790L|GAK_uc010ibi.2_Missense_Mutation_p.V77L|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Missense_Mutation_p.V760L	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	896					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		TGCGGGGGTACAGCTGGCCCT	0.701													1	0	5.35267e-07	0.007413	5.57884e-07	16	6										A	860930	C	A	860930	3	1	121	1	0	0	0	0	1	0	0	0	6195	478	17	4	1281	4	GAK	4	860930	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		860930	190293346	128	36163										
RGS12	6002	broad.mit.edu	37	chr4	3424264	3424264	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cggcatggcatcaacggggcGgccgcggacctcttcctggt	15	14	2	0	rs139780010		TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:3424264G>A	uc003ggw.2	+	11	3904	c.3000G>A	c.(2998-3000)GCG>GCA	p.A1000A	RGS12_uc003ggv.2_Silent_p.A1000A|RGS12_uc003ggy.1_Silent_p.A398A|RGS12_uc003ggz.2_Silent_p.A352A|RGS12_uc010icu.1_Silent_p.A199A|RGS12_uc011bvs.1_Silent_p.A342A|RGS12_uc003gha.2_Silent_p.A342A|RGS12_uc010icv.2_Silent_p.A199A|RGS12_uc003ghb.2_Silent_p.A199A	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1000	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCAACGGGGCGGCCGCGGACC	0.672													0	0	0	0.006122	0	13	44										A	3424264	G	A	3424264	2	1	121	1	0	0	0	0	0	0	0	1	13295	1103	39	2		2	RGS12	4	3424264	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2563334	3424264	187730012	129	36164										
HGFAC	3083	broad.mit.edu	37	chr4	3449273	3449273	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagcacttcttcaaccgcacGacggacgtgacgcagacctt	9	15	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:3449273G>A	uc003ghc.2	+	11	1413	c.1410G>A	c.(1408-1410)ACG>ACA	p.T470T	HGFAC_uc010icw.2_Silent_p.T477T	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	470	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TCAACCGCACGACGGACGTGA	0.662													0	0	0	0.00361	0	218	127										A	3449273	G	A	3449273	2	1	121	1	0	0	0	0	0	0	0	1	7086	1045	37	1		1	HGFAC	4	3449273	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	25009	3449273	187705003	130	36165										
STK32B	55351	broad.mit.edu	37	chr4	5468533	5468533	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	attggcaaagaacagatccaGggatggcacaaaggacagct	12	8	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:5468533G>A	uc003gih.1	+	10	1077	c.1013G>A	c.(1012-1014)AGG>AAG	p.R338K	STK32B_uc010ida.1_Missense_Mutation_p.R291K	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	338							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AACAGATCCAGGGATGGCACA	0.517													0	0	0	0.009535	0	24	15										A	5468533	G	A	5468533	3	1	121	1	0	0	0	0	1	0	0	0	15297	1000	35	2	1051	2	STK32B	4	5468533	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2019260	5468533	185685743	131	36166										
HTRA3	94031	broad.mit.edu	37	chr4	8288388	8288388	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgcccacgtggtgtccagcAacagtgctgccccgggcagg	14	14	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:8288388A>C	uc003gla.2	+	3	790	c.586A>C	c.(586-588)AAC>CAC	p.N196H	HTRA3_uc003gkz.2_Missense_Mutation_p.N196H	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	196	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						GGTGTCCAGCAACAGTGCTGC	0.592													0	0	0	0.001168	0	5	121										C	8288388	A	C	8288388	3	2	121	1	0	0	0	0	1	0	0	0	7455	130	5	5	596	5	HTRA3	4	8288388	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2819855	8288388	182865888	132	36167										
C4orf23	152992	broad.mit.edu	37	chr4	8469757	8469757	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctgtaagcccacctggctgGgagctttccccttctccacg	9	17	1	0	rs35357682	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:8469757G>C	uc003glg.1	+	9	1112	c.924G>C	c.(922-924)TGG>TGC	p.W308C	C4orf23_uc003glf.1_Missense_Mutation_p.W296C|C4orf23_uc003glh.1_Missense_Mutation_p.W145C	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	537					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						CACCTGGCTGGGAGCTTTCCC	0.587													0	0	0	0.008871	0	15	10										C	8469757	G	C	8469757	3	2	121	1	0	0	0	0	1	0	0	0	2256	1241	43	4	1645	4	C4orf23	4	8469757	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	181369	8469757	182684519	133	36168										
LDB2	9079	broad.mit.edu	37	chr4	16900017	16900017	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcttgttcatctcatagattCggtactctggctgtaccatg	8	10	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:16900017C>T	uc003goz.2	-	1	408	c.92G>A	c.(91-93)CGA>CAA	p.R31Q	LDB2_uc003gpa.2_Missense_Mutation_p.R31Q|LDB2_uc003gpb.2_Missense_Mutation_p.R31Q|LDB2_uc011bxh.1_Missense_Mutation_p.R31Q|LDB2_uc010iee.2_Missense_Mutation_p.R31Q	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	31							LIM domain binding|transcription cofactor activity				0						CTCATAGATTCGGTACTCTGG	0.453													0	0	0	0.00499	0	17	49										T	16900017	C	T	16900017	3	4	121	1	0	0	0	0	1	0	0	0	8696	884	31	1	1170	1	LDB2	4	16900017	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	8430260	16900017	174254259	134	36169										
FRYL	285527	broad.mit.edu	37	chr4	48592691	48592691	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctaacctatgacttttgcttCttcatctgtcaaggttttat	5	9	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:48592691C>G	uc003gyh.1	-	17	2097	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q	FRYL_uc003gyk.2_Missense_Mutation_p.E498Q	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						ACTTTTGCTTCTTCATCTGTC	0.299													0	0	0	0.004007	0	13	22										G	48592691	C	G	48592691	3	3	121	1	0	0	0	0	1	0	0	0	6064	922	32	1	7741	1	FRYL	4	48592691	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	31692674	48592691	142561585	135	36170										
PDGFRA	5156	broad.mit.edu	37	chr4	55144549	55144549	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gccccatttacatcatcacaGagtattgcttctatggagat	7	10	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:55144549G>C	uc003han.3	+	15	2354	c.2023G>C	c.(2023-2025)GAG>CAG	p.E675Q	PDGFRA_uc003haa.2_Missense_Mutation_p.E435Q|PDGFRA_uc010igq.1_Missense_Mutation_p.E569Q|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_Missense_Mutation_p.E54Q	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	675	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CATCATCACAGAGTATTGCTT	0.433			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.00333	0	17	26										C	55144549	G	C	55144549	3	2	121	1	0	0	0	0	1	0	0	0	11661	943	33	1	2077	1	PDGFRA	4	55144549	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6551858	55144549	136009727	136	36171										
LPHN3	23284	broad.mit.edu	37	chr4	62800644	62800644	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acgagtgatcagctgcgtgcGgccaccatgttgcttcatac	11	12	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:62800644G>T	uc010ihh.2	+	11	2168	c.1995G>T	c.(1993-1995)GCG>GCT	p.A665A	LPHN3_uc003hcq.3_Silent_p.A665A|LPHN3_uc003hct.2_Silent_p.A58A|LPHN3_uc003hcs.1_Silent_p.A481A	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	652	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AGCTGCGTGCGGCCACCATGT	0.463													1	0	5.4927e-09	0.004482	5.8158e-09	7	27										T	62800644	G	T	62800644	2	4	121	1	0	0	0	0	0	0	0	1	8917	1103	39	4		4	LPHN3	4	62800644	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	7656095	62800644	128353632	137	36172										
C4orf35	85438	broad.mit.edu	37	chr4	71201390	71201390	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccaggtcactgattccactAttcctgaggctgaaatccct	7	13	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:71201390A>G	uc003hff.2	+	1	720	c.634A>G	c.(634-636)ATT>GTT	p.I212V		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	212						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				TGATTCCACTATTCCTGAGGC	0.428													0	0	0	0.00632	0	18	26										G	71201390	A	G	71201390	3	3	121	1	0	0	0	0	1	0	0	0	2265	449	16	5	636	5	C4orf35	4	71201390	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	8400746	71201390	119952886	138	36173										
MUC7	4589	broad.mit.edu	37	chr4	71347138	71347138	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcaactacaccagctccacCatcttcctcagctccaccag	4	19	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:71347138C>T	uc011cat.1	+	4	965	c.677C>T	c.(676-678)CCA>CTA	p.P226L	MUC7_uc011cau.1_Missense_Mutation_p.P226L|MUC7_uc003hfj.2_Missense_Mutation_p.P226L|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	226	3.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CCAGCTCCACCATCTTCCTCA	0.582													0	0	0	0.000602	0	5	244										T	71347138	C	T	71347138	3	4	121	1	0	0	0	0	1	0	0	0	9981	594	21	2	683	2	MUC7	4	71347138	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	145748	71347138	119807138	139	36174										
RASGEF1B	153020	broad.mit.edu	37	chr4	82355883	82355883	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagagactgaagaatggtatCacaatctagaggaaacaaaa	9	5	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:82355883C>T	uc003hmi.1	-	11	1254	c.1110G>A	c.(1108-1110)GTG>GTA	p.V370V	RASGEF1B_uc003hmj.1_Silent_p.V369V|RASGEF1B_uc010ijq.1_Silent_p.V328V	NM_152545	NP_689758	Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	370	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						AGAATGGTATCACAATCTAGA	0.358													0	0	0	0.004482	0	7	5										T	82355883	C	T	82355883	2	4	121	1	0	0	0	0	0	0	0	1	13070	813	29	1		1	RASGEF1B	4	82355883	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	11008745	82355883	108798393	140	36175										
MRPS18C	51023	broad.mit.edu	37	chr4	84382165	84382165	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaaagaaatcacaaaagcaaTtaagagagctcaaataatgg	8	5	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:84382165T>A	uc003hor.3	+	5	445	c.332T>A	c.(331-333)ATT>AAT	p.I111N	MRPS18C_uc011ccu.1_Missense_Mutation_p.I111N|FAM175A_uc003hot.2_3'UTR|FAM175A_uc003hou.2_3'UTR|FAM175A_uc003hov.2_3'UTR	NM_016067	NP_057151	Q9Y3D5	RT18C_HUMAN	mitochondrial ribosomal protein S18C precursor	111					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0		Hepatocellular(203;0.114)				ACAAAAGCAATTAAGAGAGCT	0.279													0	0	0	0.006214	0	7	23										A	84382165	T	A	84382165	3	1	121	1	0	0	0	0	1	0	0	0	9830	1493	52	5	350	5	MRPS18C	4	84382165	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2026282	84382165	106772111	141	36176										
MAPK10	5602	broad.mit.edu	37	chr4	87080492	87080492	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagccaataggctttagattCtggtagcgcttgagaactgt	12	7	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:87080492C>T	uc003hpq.2	-	3	262	c.195G>A	c.(193-195)CAG>CAA	p.Q65Q	MAPK10_uc010ikg.2_Silent_p.Q27Q|MAPK10_uc003hpr.2_Silent_p.Q27Q|MAPK10_uc003hps.2_Silent_p.Q65Q|MAPK10_uc003hpt.2_Silent_p.Q65Q|MAPK10_uc003hpu.2_Silent_p.Q65Q|MAPK10_uc003hpv.2_5'UTR|MAPK10_uc010ikh.1_RNA|uc003hpw.2_Intron	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	65	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		GCTTTAGATTCTGGTAGCGCT	0.443													0	0	0	0.010729	0	11	45										T	87080492	C	T	87080492	2	4	121	1	0	0	0	0	0	0	0	1	9272	912	32	1		1	MAPK10	4	87080492	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2698327	87080492	104073784	142	36177										
RG9MTD2	93587	broad.mit.edu	37	chr4	100479265	100479265	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaggcgaagggtgctatgaaCaacatctcttcgaacacgtt	10	9	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:100479265C>T	uc003huy.2	-	3	602	c.289G>A	c.(289-291)GTT>ATT	p.V97I	RG9MTD2_uc003huz.3_Missense_Mutation_p.V97I|RG9MTD2_uc003hva.3_Missense_Mutation_p.V97I	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	97							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		GTGCTATGAACAACATCTCTT	0.353													0	0	0	0.00245	0	13	11										T	100479265	C	T	100479265	3	4	121	1	0	0	0	0	1	0	0	0	13272	478	17	2	754	2	RG9MTD2	4	100479265	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	13398773	100479265	90675011	143	36178										
ENPEP	2028	broad.mit.edu	37	chr4	111441503	111441503	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acccaagagctaacccttctCagcccccttcagatcttggg	7	16	3	2	rs138043602	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:111441503C>G	uc003iab.3	+	10	2050	c.1708C>G	c.(1708-1710)CAG>GAG	p.Q570E		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	570	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TAACCCTTCTCAGCCCCCTTC	0.413													0	0	0	0.005443	0	21	18										G	111441503	C	G	111441503	3	3	121	1	0	0	0	0	1	0	0	0	5128	827	29	1	1746	1	ENPEP	4	111441503	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	10962238	111441503	79712773	144	36179										
ANK2	287	broad.mit.edu	37	chr4	114179491	114179491	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggcctcacaccaatacatgTggctgccttcatgggccact	9	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:114179491T>C	uc003ibe.3	+	13	1410	c.1310T>C	c.(1309-1311)GTG>GCG	p.V437A	ANK2_uc003ibd.3_Missense_Mutation_p.V416A|ANK2_uc003ibf.3_Missense_Mutation_p.V437A|ANK2_uc003ibc.2_Missense_Mutation_p.V413A|ANK2_uc011cgb.1_Missense_Mutation_p.V452A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	437	ANK 13.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCAATACATGTGGCTGCCTTC	0.488													0	0	0	0.005524	0	28	96										C	114179491	T	C	114179491	3	2	121	1	0	0	0	0	1	0	0	0	621	1696	59	5	1385	5	ANK2	4	114179491	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2737988	114179491	76974785	145	36180										
SYNPO2	171024	broad.mit.edu	37	chr4	119951885	119951885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gccccctccatggccccagcCtgccccgtggtcccagccag	10	22	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:119951885C>T	uc003icm.3	+	4	2151	c.1955C>T	c.(1954-1956)CCT>CTT	p.P652L	SYNPO2_uc010ina.2_Missense_Mutation_p.P652L|SYNPO2_uc010inb.2_Missense_Mutation_p.P652L|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.P580L	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	652	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						TGGCCCCAGCCTGCCCCGTGG	0.582													0	0	0	0.004289	0	28	24										T	119951885	C	T	119951885	3	4	121	1	0	0	0	0	1	0	0	0	15454	681	24	2	1969	2	SYNPO2	4	119951885	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5772394	119951885	71202391	146	36181										
PDE5A	8654	broad.mit.edu	37	chr4	120527872	120527872	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcccctgtttacctcatatgCatctttgatgttcaagggct	7	11	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:120527872C>A	uc003idh.2	-	2	888	c.733G>T	c.(733-735)GCA>TCA	p.A245S	PDE5A_uc003idf.2_Missense_Mutation_p.A203S|PDE5A_uc003idg.2_Missense_Mutation_p.A193S	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	245	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	ACCTCATATGCATCTTTGATG	0.507													1	0	2.29192e-23	0.00361	2.63175e-23	39	44										A	120527872	C	A	120527872	3	1	121	1	0	0	0	0	1	0	0	0	11644	710	25	4	1974	4	PDE5A	4	120527872	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	575987	120527872	70626404	147	36182										
ANKRD50	57182	broad.mit.edu	37	chr4	125593360	125593360	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caaaggtcggcaggctgcaaGaatcacattcaaaataggct	10	9	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:125593360G>A	uc003ifg.3	-	3	1338	c.1072C>T	c.(1072-1074)CTT>TTT	p.L358F	ANKRD50_uc011cgo.1_Missense_Mutation_p.L179F|ANKRD50_uc010inw.2_Missense_Mutation_p.L358F	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	358										central_nervous_system(1)	1						CAGGCTGCAAGAATCACATTC	0.383													0	0	0	0.010818	0	25	50										A	125593360	G	A	125593360	3	1	121	1	0	0	0	0	1	0	0	0	677	942	33	1	3221	1	ANKRD50	4	125593360	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5065488	125593360	65560916	148	36183										
INPP4B	8821	broad.mit.edu	37	chr4	143007320	143007320	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcagccagccacataatttCtacattctttctttttttgg	5	10	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:143007320C>T	uc003iix.3	-	25	3059	c.2464G>A	c.(2464-2466)GAA>AAA	p.E822K	INPP4B_uc003iiw.3_Missense_Mutation_p.E822K|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.E637K|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	822					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					CACATAATTTCTACATTCTTT	0.358													0	0	0	0.004007	0	11	8										T	143007320	C	T	143007320	3	4	121	1	0	0	0	0	1	0	0	0	7753	922	32	1	322	1	INPP4B	4	143007320	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17413960	143007320	48146956	149	36184										
GUCY1A3	2982	broad.mit.edu	37	chr4	156634314	156634314	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcaatcttgtttttggggtCaccctgtgtggacagattag	12	7	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:156634314C>T	uc003iov.2	+	8	1687	c.1151C>T	c.(1150-1152)TCA>TTA	p.S384L	GUCY1A3_uc010iqc.2_Missense_Mutation_p.S384L|GUCY1A3_uc003iow.2_Missense_Mutation_p.S384L|GUCY1A3_uc010iqd.2_Missense_Mutation_p.S383L|GUCY1A3_uc003iox.2_Missense_Mutation_p.S384L|GUCY1A3_uc003ioz.2_Missense_Mutation_p.S149L|GUCY1A3_uc003ioy.2_Missense_Mutation_p.S384L|GUCY1A3_uc010iqe.2_Missense_Mutation_p.S149L|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Missense_Mutation_p.S384L	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	384					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TTTTTGGGGTCACCCTGTGTG	0.428													0	0	0	0.010504	0	18	32										T	156634314	C	T	156634314	3	4	121	1	0	0	0	0	1	0	0	0	6894	838	29	1	1184	1	GUCY1A3	4	156634314	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	13626994	156634314	34519962	150	36185										
TMEM144	55314	broad.mit.edu	37	chr4	159174635	159174635	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	taatgatacttgcattttgcAtcatcttgactggagcctta	7	8	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:159174635A>G	uc003ipx.2	+	13	1514	c.994A>G	c.(994-996)ATC>GTC	p.I332V	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	332	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		TGCATTTTGCATCATCTTGAC	0.378													0	0	0	0.00623	0	27	62										G	159174635	A	G	159174635	3	3	121	1	0	0	0	0	1	0	0	0	16055	217	8	5	1036	5	TMEM144	4	159174635	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2540321	159174635	31979641	151	36186										
ADAM29	11086	broad.mit.edu	37	chr4	175898028	175898028	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agactgcaagttcctaccatCagggaaagtgtgtagaaagg	12	7	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:175898028C>G	uc003iuc.2	+	5	2022	c.1352C>G	c.(1351-1353)TCA>TGA	p.S451*	ADAM29_uc003iud.2_Nonsense_Mutation_p.S451*|ADAM29_uc010irr.2_Nonsense_Mutation_p.S451*|ADAM29_uc011cki.1_Nonsense_Mutation_p.S451*	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	451	Disintegrin.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCCTACCATCAGGGAAAGTG	0.443													0	0	0	0.002299	0	15	29										G	175898028	C	G	175898028	4	3	121	1	0	0	0	0	0	1	0	0	247	838	29	1	1354	1	ADAM29	4	175898028	Nonsense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	16723393	175898028	15256248	152	36187										
WDR17	116966	broad.mit.edu	37	chr4	177089822	177089822	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccccttttgttacgttaacaGgaatttggcagctgatcttc	8	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:177089822G>A	uc003iuj.2	+	25	3263	c.3107G>A	c.(3106-3108)AGG>AAG	p.R1036K	WDR17_uc003iuk.2_Missense_Mutation_p.R1012K|WDR17_uc003ium.3_Splice_Site_p.W997_splice|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Splice_Site_p.R247_splice	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1036										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TACGTTAACAGGAATTTGGCA	0.338													0	0	0	0.010729	0	7	43										A	177089822	G	A	177089822	3	1	121	1	0	0	0	0	1	0	0	0	17274	1014	35	2	3201	2	WDR17	4	177089822	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1191794	177089822	14064454	153	36188										
CDKN2AIP	55602	broad.mit.edu	37	chr4	184367945	184367945	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttcccaggtagctgcatcaCtactagcttccaagagcagc	8	14	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:184367945C>T	uc003ivp.1	+	3	1270	c.1108C>T	c.(1108-1110)CTA>TTA	p.L370L	CDKN2AIP_uc003ivq.1_Silent_p.L115L	NM_017632	NP_060102	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	370	Ser-rich.				negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding				0		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AGCTGCATCACTACTAGCTTC	0.488													0	0	0	0.00632	0	21	38										T	184367945	C	T	184367945	2	4	121	1	0	0	0	0	0	0	0	1	3162	564	20	2		2	CDKN2AIP	4	184367945	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7278123	184367945	6786331	154	36189										
SORBS2	8470	broad.mit.edu	37	chr4	186544731	186544731	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	actgcagaaggatgacccctCtaggtgaatgtagtcactgt	11	9	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:186544731C>G	uc003iyl.2	-	13	2698	c.1840G>C	c.(1840-1842)GAG>CAG	p.E614Q	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.E714Q|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.E518Q|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.E728Q|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	614						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GATGACCCCTCTAGGTGAATG	0.463													0	0	0	0.003271	0	29	23										G	186544731	C	G	186544731	3	3	121	1	0	0	0	0	1	0	0	0	14928	922	32	1	1498	1	SORBS2	4	186544731	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2176786	186544731	4609545	155	36190										
FAT1	2195	broad.mit.edu	37	chr4	187541806	187541807	+	Frame_Shift_Ins	INS	-	-	TTTAGGTGACT													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtagacatcctgggtaaacINStttaggtgactttctttgct							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr4:187541806_187541807insTTTAGGTGACT	uc003izf.2	-	10	6121_6122	c.5933_5934insAGTCACCTAAA	c.(5932-5934)AAGfs	p.K1978fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1978	Extracellular (Potential).|Cadherin 17.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CCTGGGTAAACTTTAGGTGACT	0.45										HNSCC(5;0.00058)								10	231	---	---								TTTAGGTGACT	187541807	-	TTTAGGTGACT	187541806	7	5	121	1	0	1	1	0	0	0	0	0	5689	564	20	0	7904	0	FAT1	4	187541806	Frame_Shift_Ins	INS	-	TCGA-GV-A3QI-01A-11D-A21Z-08	997075	187541806	3612470	156	36191										
DNAH5	1767	broad.mit.edu	37	chr5	13753590	13753590	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttccgccagtcatttaacaGaagatcacgaaactcttggt	7	11	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:13753590G>A	uc003jfd.2	-	63	10666	c.10624C>T	c.(10624-10626)CTG>TTG	p.L3542L	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3542					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCATTTAACAGAAGATCACGA	0.373									Kartagener_syndrome				0	0	0	0.007835	0	33	68										A	13753590	G	A	13753590	2	1	121	1	0	0	0	0	0	0	0	1	4604	933	33	1		1	DNAH5	5	13753590	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		13753590	167161670	157	36192										
RNASEN	29102	broad.mit.edu	37	chr5	31431748	31431748	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	attctctacaaaggtcaggcCcgtgagcatacagcataaat	8	10	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:31431748C>T	uc003jhg.2	-	25	3439	c.3080G>A	c.(3079-3081)GGG>GAG	p.G1027E	RNASEN_uc003jhh.2_Missense_Mutation_p.G990E|RNASEN_uc003jhi.2_Missense_Mutation_p.G990E	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	1027	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|RNase III 1.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						AAGGTCAGGCCCGTGAGCATA	0.373													0	0	0	0.011902	0	30	48										T	31431748	C	T	31431748	3	4	121	1	0	0	0	0	1	0	0	0	13417	623	22	2	1088	2	RNASEN	5	31431748	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17678158	31431748	149483512	158	36193										
C9	735	broad.mit.edu	37	chr5	39288867	39288867	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gatttcacaggcaattccctCaaatttgaatgggcaggcac	9	10	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:39288867C>G	uc003jlv.3	-	10	1692	c.1603G>C	c.(1603-1605)GAG>CAG	p.E535Q		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	535	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GCAATTCCCTCAAATTTGAAT	0.348													0	0	0	0.00361	0	50	82										G	39288867	C	G	39288867	3	3	121	1	0	0	0	0	1	0	0	0	2443	835	29	1	84	1	C9	5	39288867	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7857119	39288867	141626393	159	36194										
PAIP1	10605	broad.mit.edu	37	chr5	43547879	43547879	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcaaagcatcatctgttgtaAcacaaccattcagggtctct	7	11	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:43547879A>T	uc003job.2	-	3	819	c.572T>A	c.(571-573)GTT>GAT	p.V191D	PAIP1_uc003joa.2_Missense_Mutation_p.V112D|PAIP1_uc010ivp.2_Missense_Mutation_p.V112D|PAIP1_uc010ivo.2_RNA|PAIP1_uc003joc.2_Missense_Mutation_p.V79D	NM_006451	NP_006442	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	191	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			ovary(1)	1	Lung NSC(6;2.07e-05)					ATCTGTTGTAACACAACCATT	0.408													0	0	0	0.00361	0	56	63										T	43547879	A	T	43547879	3	4	121	1	0	0	0	0	1	0	0	0	11396	43	2	5	903	5	PAIP1	5	43547879	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4259012	43547879	137367381	160	36195										
HCN1	348980	broad.mit.edu	37	chr5	45303881	45303881	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggcagtcacaaaattaggatCcgcattagcaaataaaggca	9	8	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:45303881C>A	uc003jok.2	-	6	1463	c.1438G>T	c.(1438-1440)GAT>TAT	p.D480Y		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	480	cAMP.|Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						AAATTAGGATCCGCATTAGCA	0.383													1	0	1.21826e-31	0.00361	1.42594e-31	60	88										A	45303881	C	A	45303881	3	1	121	1	0	0	0	0	1	0	0	0	6996	855	30	3	1246	3	HCN1	5	45303881	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1756002	45303881	135611379	161	36196										
GPR98	84059	broad.mit.edu	37	chr5	90101230	90101230	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctggatatgctcctgggttaGaaattcctgaattcattgtt	9	7	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:90101230G>C	uc003kju.2	+	72	14887	c.14791G>C	c.(14791-14793)GAA>CAA	p.E4931Q	GPR98_uc003kjt.2_Missense_Mutation_p.E2637Q|GPR98_uc003kjw.2_Missense_Mutation_p.E592Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4931	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCTGGGTTAGAAATTCCTGA	0.453													0	0	0	0.00361	0	38	2										C	90101230	G	C	90101230	3	2	121	1	0	0	0	0	1	0	0	0	6721	943	33	1	15077	1	GPR98	5	90101230	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	44797349	90101230	90814030	162	36197										
GPR98	84059	broad.mit.edu	37	chr5	90106817	90106817	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcagaagttcttatccgaaGaactggtgggtttactggca	12	7	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:90106817G>A	uc003kju.2	+	74	15836	c.15740G>A	c.(15739-15741)AGA>AAA	p.R5247K	GPR98_uc003kjt.2_Missense_Mutation_p.R2953K|GPR98_uc003kjw.2_Missense_Mutation_p.R908K	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5247	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTATCCGAAGAACTGGTGGG	0.418													0	0	0	0.012213	0	31	0										A	90106817	G	A	90106817	3	1	121	1	0	0	0	0	1	0	0	0	6721	942	33	1	16034	1	GPR98	5	90106817	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5587	90106817	90808443	163	36198										
DMXL1	1657	broad.mit.edu	37	chr5	118440935	118440935	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggaatcaatagcacacaatAtaacctgggatcccacaggt	8	10	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:118440935A>G	uc003ksd.2	+	4	527	c.346A>G	c.(346-348)ATA>GTA	p.I116V	DMXL1_uc010jcl.1_Missense_Mutation_p.I116V|DMXL1_uc003ksc.1_Missense_Mutation_p.I116V	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	116	WD 1.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		AGCACACAATATAACCTGGGA	0.318													0	0	0	0.004289	0	27	23										G	118440935	A	G	118440935	3	3	121	1	0	0	0	0	1	0	0	0	4594	449	16	5	360	5	DMXL1	5	118440935	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	28334118	118440935	62474325	164	36199										
FBN2	2201	broad.mit.edu	37	chr5	127674745	127674745	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtcaggagaaatcctgcactCgtcgatgtctaattcacagg	10	10	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:127674745C>A	uc003kuu.2	-	26	3791	c.3352G>T	c.(3352-3354)GAG>TAG	p.E1118*	FBN2_uc003kuv.2_Nonsense_Mutation_p.E1085*	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1118	EGF-like 16; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ATCCTGCACTCGTCGATGTCT	0.458													1	0	1.67305e-13	0.00623	1.83567e-13	26	28										A	127674745	C	A	127674745	4	1	121	1	0	0	0	0	0	1	0	0	5703	893	31	3	5546	3	FBN2	5	127674745	Nonsense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9233810	127674745	53240515	165	36200										
LECT2	3950	broad.mit.edu	37	chr5	135288607	135288607	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggcggtcacacgtccggatCtcattggaagacttgccagc	12	12	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:135288607C>A	uc003lbe.1	-	2	297	c.96G>T	c.(94-96)GAG>GAT	p.E32D		NM_002302	NP_002293	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2 precursor	32					chemotaxis|skeletal system development	cytoplasm|extracellular space				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACGTCCGGATCTCATTGGAAG	0.507													1	0	6.40141e-05	0.010729	6.55898e-05	8	283										A	135288607	C	A	135288607	3	1	121	1	0	0	0	0	1	0	0	0	8713	912	32	3	371	3	LECT2	5	135288607	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7613862	135288607	45626653	166	36201										
FAM13B	51306	broad.mit.edu	37	chr5	137347541	137347541	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgctacattggctaaaaatCtacacagaaactttaacaaa	4	8	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:137347541C>G	uc003lbz.2	-	5	998	c.464G>C	c.(463-465)AGA>ACA	p.R155T	FAM13B_uc003lcb.2_Missense_Mutation_p.R37T|FAM13B_uc003lca.2_Missense_Mutation_p.R155T	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	155	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						GGCTAAAAATCTACACAGAAA	0.338													0	0	0	0.010818	0	24	25										G	137347541	C	G	137347541	3	3	121	1	0	0	0	0	1	0	0	0	5453	913	32	1	2429	1	FAM13B	5	137347541	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2058934	137347541	43567719	167	36202										
PCDHA6	56142	broad.mit.edu	37	chr5	140209923	140209923	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcgcagtggggagctggtcGtactcgcagcagaggcggca	18	10	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:140209923G>A	uc003lho.2	+	1	2274	c.2247G>A	c.(2245-2247)TCG>TCA	p.S749S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S749S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	749	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGCTGGTCGTACTCGCAGC	0.657													0	0	0	0.001168	0	3	52										A	140209923	G	A	140209923	2	1	121	1	0	0	0	0	0	0	0	1	11528	1132	40	2		2	PCDHA6	5	140209923	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2862382	140209923	40705337	168	36203										
PCDHA8	56140	broad.mit.edu	37	chr5	140221688	140221688	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgcagacaacggaacaacagTtatcaaactgaatgcttctg	8	10	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:140221688T>A	uc003lhs.2	+	1	782	c.782T>A	c.(781-783)GTT>GAT	p.V261D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.V261D	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	261	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAACAACAGTTATCAAACTG	0.408													0	0	0	0.008361	0	27	38										A	140221688	T	A	140221688	3	1	121	1	0	0	0	0	1	0	0	0	11530	1725	60	5	784	5	PCDHA8	5	140221688	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	11765	140221688	40693572	169	36204										
PCDHA12	56137	broad.mit.edu	37	chr5	140255207	140255207	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttcgtgggccgcatcgctcaGgacctggggctggagctggc	17	12	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:140255207G>A	uc003lic.2	+	1	277	c.150G>A	c.(148-150)CAG>CAA	p.Q50Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.Q50Q	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	50	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCATCGCTCAGGACCTGGGGC	0.642													0	0	0	0.007291	0	21	35										A	140255207	G	A	140255207	2	1	121	1	0	0	0	0	0	0	0	1	11522	991	35	2		2	PCDHA12	5	140255207	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	33519	140255207	40660053	170	36205										
PCDHB16	57717	broad.mit.edu	37	chr5	140563833	140563833	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcgtgctgtacccgctgcagAacggctccgcgccctgcact	11	17	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:140563833A>G	uc003liv.2	+	1	2854	c.1699A>G	c.(1699-1701)AAC>GAC	p.N567D		NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	567	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCGCTGCAGAACGGCTCCGC	0.711													0	0	0	0.004656	0	20	86										G	140563833	A	G	140563833	3	3	121	1	0	0	0	0	1	0	0	0	11541	246	9	5	1701	5	PCDHB16	5	140563833	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	308626	140563833	40351427	171	36206										
PCDHB10	56126	broad.mit.edu	37	chr5	140573673	140573673	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aacggccacctgttcgccctCaggtcgctggactacgaggc	12	15	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:140573673C>T	uc003lix.2	+	1	1722	c.1548C>T	c.(1546-1548)CTC>CTT	p.L516L		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	516	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCGCCCTCAGGTCGCTGG	0.706													0	0	0	0.00361	0	76	224										T	140573673	C	T	140573673	2	4	121	1	0	0	0	0	0	0	0	1	11535	813	29	1		1	PCDHB10	5	140573673	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9840	140573673	40341587	172	36207										
PCDHGA11	56105	broad.mit.edu	37	chr5	140800805	140800805	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agagcctgccatggcgaatcGgctacagcgcggggaccgca	15	13	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:140800805G>A	uc003lkq.1	+	1	269	c.11G>A	c.(10-12)CGG>CAG	p.R4Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.R4Q|PCDHGA11_uc003lkp.1_Missense_Mutation_p.R4Q	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	4					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGGCGAATCGGCTACAGCGC	0.592													0	0	0	0.004482	0	5	15										A	140800805	G	A	140800805	3	1	121	1	0	0	0	0	1	0	0	0	11552	1116	39	2	13	2	PCDHGA11	5	140800805	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	227132	140800805	40114455	173	36208										
ARAP3	64411	broad.mit.edu	37	chr5	141035204	141035204	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttaccagggtctgattggcaGagaggagggtggctccactg	16	8	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:141035204G>A	uc003llm.2	-	31	4172	c.4094C>T	c.(4093-4095)TCT>TTT	p.S1365F	ARAP3_uc003lll.2_Missense_Mutation_p.S316F|ARAP3_uc011dbe.1_Missense_Mutation_p.S1027F|ARAP3_uc003lln.2_Missense_Mutation_p.S1196F	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1365					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTGATTGGCAGAGAGGAGGGT	0.587													0	0	0	0.00499	0	13	74										A	141035204	G	A	141035204	3	1	121	1	0	0	0	0	1	0	0	0	840	942	33	1	552	1	ARAP3	5	141035204	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	234399	141035204	39880056	174	36209										
PCDH1	5097	broad.mit.edu	37	chr5	141243228	141243228	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caggtccttggtctccttctTaccagcctggtaaccacttt	7	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:141243228T>C	uc003llq.2	-	3	2785	c.2668A>G	c.(2668-2670)AAG>GAG	p.K890E	PCDH1_uc003llp.2_Missense_Mutation_p.K890E|PCDH1_uc011dbf.1_Missense_Mutation_p.K868E	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	890	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTCTCCTTCTTACCAGCCTGG	0.587													0	0	0	0.00361	0	92	97										C	141243228	T	C	141243228	3	2	121	1	0	0	0	0	1	0	0	0	11506	1763	61	5	1141	5	PCDH1	5	141243228	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	208024	141243228	39672032	175	36210										
SLC6A7	6534	broad.mit.edu	37	chr5	149585112	149585112	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agctgctgggcatcctgatgGgcctgctgtcctgcctcatg	13	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:149585112G>A	uc003lrr.2	+	13	1998	c.1627G>A	c.(1627-1629)GGC>AGC	p.G543S		NM_014228	NP_055043	Q99884	SC6A7_HUMAN	solute carrier family 6, member 7	543	Helical; Name=12; (Potential).					integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity				0		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	CATCCTGATGGGCCTGCTGTC	0.612													0	0	0	0.00361	0	60	47										A	149585112	G	A	149585112	3	1	121	1	0	0	0	0	1	0	0	0	14689	1232	43	2	1677	2	SLC6A7	5	149585112	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8341884	149585112	31330148	176	36211										
SYNPO	11346	broad.mit.edu	37	chr5	150029566	150029566	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgctctttgtcctctcacctAtcaaggagcctgccaaggtc	8	15	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:150029566A>C	uc003lsn.2	+	3	2835	c.2461A>C	c.(2461-2463)ATC>CTC	p.I821L	SYNPO_uc003lso.3_Missense_Mutation_p.I577L|SYNPO_uc003lsp.2_Missense_Mutation_p.I577L	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	821	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTCTCACCTATCAAGGAGCC	0.652													0	0	0	0.00361	0	46	52										C	150029566	A	C	150029566	3	2	121	1	0	0	0	0	1	0	0	0	15453	449	16	5	2467	5	SYNPO	5	150029566	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	444454	150029566	30885694	177	36212										
IL12B	3593	broad.mit.edu	37	chr5	158750268	158750268	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggtgataccatcttcttcaGgggtgtcacaggtgaggacc	13	9	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:158750268G>T	uc003lxr.1	-	3	200	c.158C>A	c.(157-159)CCT>CAT	p.P53H		NM_002187	NP_002178	P29460	IL12B_HUMAN	interleukin 12B precursor	53	Ig-like C2-type.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCTTCTTCAGGGGTGTCACA	0.483													1	0	3.57192e-18	0.006122	4.03888e-18	14	17										T	158750268	G	T	158750268	3	4	121	1	0	0	0	0	1	0	0	0	7625	1000	35	4	848	4	IL12B	5	158750268	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8720702	158750268	22164992	178	36213										
ZNF354A	6940	broad.mit.edu	37	chr5	178139071	178139071	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatctactttctaggggtccTcttcgatatgaattttataa	6	7	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:178139071T>A	uc003mjj.2	-	5	2006	c.1808A>T	c.(1807-1809)GAG>GTG	p.E603V		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	603					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		CTAGGGGTCCTCTTCGATATG	0.348													0	0	0	0.00632	0	22	15										A	178139071	T	A	178139071	3	1	121	1	0	0	0	0	1	0	0	0	17861	1551	54	5	13	5	ZNF354A	5	178139071	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	19388803	178139071	2776189	179	36214										
MAPK9	5601	broad.mit.edu	37	chr5	179675979	179675979	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccggctatactcaccgttctCtttgtagcccatacccagga	7	15	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr5:179675979C>T	uc003mls.3	-	6	881	c.610G>A	c.(610-612)GAG>AAG	p.E204K	MAPK9_uc003mlt.3_Missense_Mutation_p.E204K|MAPK9_uc010jlc.2_Missense_Mutation_p.E204K|MAPK9_uc003mlv.3_Missense_Mutation_p.E204K|MAPK9_uc011dgx.1_Missense_Mutation_p.E204K	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	204	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCACCGTTCTCTTTGTAGCCC	0.527													0	0	0	0.00361	0	248	343										T	179675979	C	T	179675979	3	4	121	1	0	0	0	0	1	0	0	0	9287	922	32	1	814	1	MAPK9	5	179675979	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1536908	179675979	1239281	180	36215										
TBC1D7	51256	broad.mit.edu	37	chr6	13327121	13327121	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acgaaagtttctctgagagtCctcagtcatatttcattctt	6	9	5	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:13327121C>G	uc003naj.2	-	2	101	c.10G>C	c.(10-12)GAC>CAC	p.D4H	TBC1D7_uc011dis.1_RNA|TBC1D7_uc003nan.2_Missense_Mutation_p.D4H|TBC1D7_uc003nal.2_Missense_Mutation_p.D4H|TBC1D7_uc003nam.2_Missense_Mutation_p.D4H|TBC1D7_uc003nao.2_Missense_Mutation_p.D4H|TBC1D7_uc010jpd.2_Missense_Mutation_p.D4H|TBC1D7_uc003nap.2_Missense_Mutation_p.D4H|TBC1D7_uc003naq.2_Missense_Mutation_p.D4H	NM_016495	NP_057579	Q9P0N9	TBCD7_HUMAN	TBC1 domain family, member 7 isoform a	4					positive regulation of protein ubiquitination	cytoplasmic membrane-bounded vesicle	protein binding|Rab GTPase activator activity			ovary(1)	1	Breast(50;0.0296)|Ovarian(93;0.0339)	all_hematologic(90;0.135)	Epithelial(50;0.0784)|BRCA - Breast invasive adenocarcinoma(129;0.13)|all cancers(50;0.21)			CTCTGAGAGTCCTCAGTCATA	0.383													0	0	0	0.001168	0	4	22										G	13327121	C	G	13327121	3	3	121	1	0	0	0	0	1	0	0	0	15621	855	30	1	899	1	TBC1D7	6	13327121	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		13327121	157787946	181	36216										
KDM1B	221656	broad.mit.edu	37	chr6	18222170	18222170	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggcatttcccacaaactgttAcaggggcatatttgagtggc	11	9	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:18222170A>G	uc003nco.1	+	15	1882	c.1807A>G	c.(1807-1809)ACA>GCA	p.T603A	KDM1B_uc003ncn.1_Missense_Mutation_p.T574A|KDM1B_uc003ncp.1_Missense_Mutation_p.T159A|KDM1B_uc003ncq.1_Missense_Mutation_p.Y157C	NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	806					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						ACAAACTGTTACAGGGGCATA	0.398													0	0	0	0.010729	0	7	136										G	18222170	A	G	18222170	3	3	121	1	0	0	0	0	1	0	0	0	8123	391	14	5	1782	5	KDM1B	6	18222170	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4895049	18222170	152892897	182	36217										
RNF39	80352	broad.mit.edu	37	chr6	30043128	30043128	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cacctccaccgccagccgcaCattagacctcaggctgcggc	9	19	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:30043128C>T	uc003npe.2	-	1	501	c.439G>A	c.(439-441)GTG>ATG	p.V147M	RNF39_uc003npd.2_Missense_Mutation_p.V147M	NM_025236	NP_079512	Q9H2S5	RNF39_HUMAN	ring finger protein 39 isoform 1	147						cytoplasm	zinc ion binding				0						GCCAGCCGCACATTAGACCTC	0.751													0	0	0	0.008291	0	8	0										T	30043128	C	T	30043128	3	4	121	1	0	0	0	0	1	0	0	0	13491	478	17	2	839	2	RNF39	6	30043128	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	11820958	30043128	141071939	183	36218										
MICB	4277	broad.mit.edu	37	chr6	31473433	31473433	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caacctcatggtgctgtcccAggatggatctgtgcagtcag	12	11	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:31473433A>G	uc003ntn.3	+	2	226	c.110A>G	c.(109-111)CAG>CGG	p.Q37R	MICB_uc011dnm.1_Missense_Mutation_p.Q5R|MICB_uc003nto.3_Missense_Mutation_p.Q37R	NM_005931	NP_005922	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	37	Extracellular (Potential).				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding				0						GTGCTGTCCCAGGATGGATCT	0.522													0	0	0	0.009096	0	3	124										G	31473433	A	G	31473433	3	3	121	1	0	0	0	0	1	0	0	0	9575	188	7	5	116	5	MICB	6	31473433	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1430305	31473433	139641634	184	36219										
COL11A2	1302	broad.mit.edu	37	chr6	33141522	33141522	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gccatcaccaccagatgttcCctgtggggggaaacagagtc	12	12	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:33141522C>T	uc003ocx.1	-	35	2812	c.2584G>A	c.(2584-2586)GGA>AGA	p.G862R	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.G776R|COL11A2_uc003ocz.1_Missense_Mutation_p.G755R	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	862	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CCAGATGTTCCCTGTGGGGGG	0.642													0	0	0	0.002299	0	18	0										T	33141522	C	T	33141522	3	4	121	1	0	0	0	0	1	0	0	0	3668	637	22	2	2754	2	COL11A2	6	33141522	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1668089	33141522	137973545	185	36220										
GRM4	2914	broad.mit.edu	37	chr6	34003490	34003490	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagaagatggggatgaaggcCagccagacgatgcaagtggt	16	6	0	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:34003490C>A	uc003oir.3	-	8	2567	c.2397G>T	c.(2395-2397)CTG>CTT	p.L799L	GRM4_uc011dsn.1_Silent_p.L752L|GRM4_uc010jvh.2_Silent_p.L799L|GRM4_uc010jvi.2_Silent_p.L491L|GRM4_uc003oio.2_Silent_p.L491L|GRM4_uc003oip.2_RNA|GRM4_uc011dsl.1_Silent_p.L659L|GRM4_uc003oiq.2_Silent_p.L666L|GRM4_uc011dsm.1_Silent_p.L630L	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	799	Helical; Name=6; (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	GGATGAAGGCCAGCCAGACGA	0.622													1	0	4.13886e-29	0.00361	4.81061e-29	46	2										A	34003490	C	A	34003490	2	1	121	1	0	0	0	0	0	0	0	1	6799	581	21	4		4	GRM4	6	34003490	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	861968	34003490	137111577	186	36221										
FKBP5	2289	broad.mit.edu	37	chr6	35586902	35586902	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgctccttcgtttggatttGaatatccctctcctttccgt	6	12	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:35586902G>C	uc011dte.1	-	5	682	c.479C>G	c.(478-480)TCA>TGA	p.S160*	FKBP5_uc003okx.2_Nonsense_Mutation_p.S160*|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Nonsense_Mutation_p.S160*|FKBP5_uc003okz.2_Nonsense_Mutation_p.S160*	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	160	PPIase FKBP-type 2.				protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						GTTTGGATTTGAATATCCCTC	0.383													0	0	0	0.00361	0	47	4										C	35586902	G	C	35586902	4	2	121	1	0	0	0	0	0	1	0	0	5911	1294	45	1	980	1	FKBP5	6	35586902	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1583412	35586902	135528165	187	36222										
MTCH1	23787	broad.mit.edu	37	chr6	36937845	36937845	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggtacttccagcagtgaatCcaggatttgaacactgggga	12	8	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:36937845C>G	uc003ond.1	-	11	1068	c.1068G>C	c.(1066-1068)TGG>TGC	p.W356C	MTCH1_uc003onc.1_Missense_Mutation_p.W339C|MTCH1_uc010jwo.1_RNA|MTCH1_uc003one.3_Missense_Mutation_p.W356C|MTCH1_uc011dtt.1_Missense_Mutation_p.W171C	NM_014341	NP_055156	Q9NZJ7	MTCH1_HUMAN	mitochondrial carrier homolog 1	356					activation of caspase activity|neuronal ion channel clustering|positive regulation of apoptosis|regulation of signal transduction|transport	integral to membrane|mitochondrial inner membrane	protein binding				0						AGCAGTGAATCCAGGATTTGA	0.552													0	0	0	0.00361	0	54	3										G	36937845	C	G	36937845	3	3	121	1	0	0	0	0	1	0	0	0	9913	856	30	1	109	1	MTCH1	6	36937845	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1350943	36937845	134177222	188	36223										
TSPO2	222642	broad.mit.edu	37	chr6	41010863	41010863	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcccattctacaaagtcttaTtgcttgtacagacagccatc	6	12	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:41010863T>C	uc003opj.2	+	2	440	c.139T>C	c.(139-141)TTG>CTG	p.L47L	UNC5CL_uc010jxe.1_Intron|TSPO2_uc003opk.2_Silent_p.Y56Y|TSPO2_uc011dub.1_Silent_p.L47L	NM_001010873	NP_001010873	Q5TGU0	TSPO2_HUMAN	benzodiazapine receptor (peripheral)-like 1	47	Helical; (Potential).				transport	endoplasmic reticulum membrane|integral to membrane	cholesterol binding|receptor activity				0						CAAAGTCTTATTGCTTGTACA	0.537													0	0	0	0.00361	0	43	89										C	41010863	T	C	41010863	2	2	121	1	0	0	0	0	0	0	0	1	16653	1490	52	5		5	TSPO2	6	41010863	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	4073018	41010863	130104204	189	36224										
GUCA1B	2979	broad.mit.edu	37	chr6	42156424	42156424	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctccagggtgcccctcagcaCgagattcagagctgccacgt	11	15	2	2	rs147956742	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:42156424C>T	uc003orz.2	-	2	389	c.253G>A	c.(253-255)GTG>ATG	p.V85M		NM_002098	NP_002089	Q9UMX6	GUC1B_HUMAN	guanylate cyclase activator 1B (retina)	85	EF-hand 2.				body fluid secretion|cell-cell signaling|receptor guanylyl cyclase signaling pathway|visual perception	plasma membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity			skin(2)	2	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00154)|STAD - Stomach adenocarcinoma(11;0.00177)			CCCCTCAGCACGAGATTCAGA	0.547													0	0	0	0.008291	0	9	22										T	42156424	C	T	42156424	3	4	121	1	0	0	0	0	1	0	0	0	6889	536	19	2	361	2	GUCA1B	6	42156424	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1145561	42156424	128958643	190	36225										
CENPQ	55166	broad.mit.edu	37	chr6	49448703	49448703	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	actctgaaagtccctcccaaAaagatggaagatttaactaa	6	9	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:49448703A>T	uc003ozh.1	+	6	476	c.387A>T	c.(385-387)AAA>AAT	p.K129N		NM_018132	NP_060602	Q7L2Z9	CENPQ_HUMAN	centromere protein Q	129					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				ovary(2)	2	Lung NSC(77;0.0128)					TCCCTCCCAAAAAGATGGAAG	0.303													0	0	0	0.008871	0	13	26										T	49448703	A	T	49448703	3	4	121	1	0	0	0	0	1	0	0	0	3241	11	1	5	405	5	CENPQ	6	49448703	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	7292279	49448703	121666364	191	36226										
MCM3	4172	broad.mit.edu	37	chr6	52141909	52141909	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagccgtcagacccactccaGaggagccccggccagtggtg	13	16	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:52141909G>A	uc003pan.1	-	8	1231	c.1121C>T	c.(1120-1122)TCT>TTT	p.S374F	MCM3_uc011dwu.1_Missense_Mutation_p.S328F	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	374	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					ACCCACTCCAGAGGAGCCCCG	0.602													0	0	0	0.008871	0	16	30										A	52141909	G	A	52141909	3	1	121	1	0	0	0	0	1	0	0	0	9387	942	33	1	1345	1	MCM3	6	52141909	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2693206	52141909	118973158	192	36227										
B3GAT2	135152	broad.mit.edu	37	chr6	71665987	71665987	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcggagcgggagtcgggcgCccccgcggcccaccgcgtag	18	16	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:71665987C>T	uc003pfv.2	-	1	802	c.146G>A	c.(145-147)GGC>GAC	p.G49D	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.G49D	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	49	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GAGTCGGGCGCCCCCGCGGCC	0.711													0	0	0	0.001168	0	5	2										T	71665987	C	T	71665987	3	4	121	1	0	0	0	0	1	0	0	0	1254	739	26	2	841	2	B3GAT2	6	71665987	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	19524078	71665987	99449080	193	36228										
OGFRL1	79627	broad.mit.edu	37	chr6	72011571	72011571	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caatgaagctgccaagccaaGaaatacagagaaggacagta	10	8	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:72011571G>A	uc003pfx.1	+	7	1338	c.1175G>A	c.(1174-1176)AGA>AAA	p.R392K		NM_024576	NP_078852	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	392						membrane	receptor activity				0						GCCAAGCCAAGAAATACAGAG	0.448													0	0	0	0.010729	0	9	14										A	72011571	G	A	72011571	3	1	121	1	0	0	0	0	1	0	0	0	10844	942	33	1	1201	1	OGFRL1	6	72011571	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	345584	72011571	99103496	194	36229										
DOPEY1	23033	broad.mit.edu	37	chr6	83835289	83835289	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatgatttctgccttgacaaGccatctccagacattgcact	6	12	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:83835289G>A	uc003pjs.1	+	15	1816	c.1556G>A	c.(1555-1557)AGC>AAC	p.S519N	DOPEY1_uc011dyy.1_Missense_Mutation_p.S510N|DOPEY1_uc010kbl.1_Missense_Mutation_p.S510N	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	519					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GCCTTGACAAGCCATCTCCAG	0.418													0	0	0	0.00361	0	43	82										A	83835289	G	A	83835289	3	1	121	1	0	0	0	0	1	0	0	0	4707	971	34	2	1606	2	DOPEY1	6	83835289	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	11823718	83835289	87279778	195	36230										
SPACA1	81833	broad.mit.edu	37	chr6	88775899	88775899	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggtttttgttttttcttccaGggcagcagtcaaggctttct	10	8	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:88775899G>T	uc003pmn.2	+	7	849	c.732_splice	c.e7-1	p.W244_splice		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor							integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TTTTCTTCCAGGGCAGCAGTC	0.343													1	0	5.16669e-11	0.010729	5.57701e-11	10	31										T	88775899	G	T	88775899	5	4	121	1	0	0	0	0	0	0	1	0	14972	1014	35	4	757	4	SPACA1	6	88775899	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4940610	88775899	82339168	196	36231										
CNR1	1268	broad.mit.edu	37	chr6	88854586	88854586	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggaggatgacgcacagcacCaggaggttctccaggaccgt	14	11	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:88854586C>A	uc011dzq.1	-	2	3971	c.408G>T	c.(406-408)CTG>CTT	p.L136L	CNR1_uc010kbz.2_Silent_p.L136L|CNR1_uc011dzr.1_Silent_p.L136L|CNR1_uc011dzs.1_Silent_p.L136L|CNR1_uc003pmq.3_Silent_p.L136L|CNR1_uc011dzt.1_Silent_p.L136L|CNR1_uc010kca.2_Silent_p.L103L	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	136	Helical; Name=1; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CGCACAGCACCAGGAGGTTCT	0.617													1	0	5.3912e-06	0.006122	5.55811e-06	12	7										A	88854586	C	A	88854586	2	1	121	1	0	0	0	0	0	0	0	1	3631	581	21	4		4	CNR1	6	88854586	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	78687	88854586	82260481	197	36232										
KIAA0776	23376	broad.mit.edu	37	chr6	97000455	97000455	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcacatcagtcctgttgtttCagttttcaacccacagcatg	6	12	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:97000455C>A	uc003por.2	+	18	2131	c.2083C>A	c.(2083-2085)CAG>AAG	p.Q695K	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	695					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		CCTGTTGTTTCAGTTTTCAAC	0.423													1	0	9.39395e-14	0.00632	1.0324e-13	22	20										A	97000455	C	A	97000455	3	1	121	1	0	0	0	0	1	0	0	0	8193	827	29	3	2153	3	KIAA0776	6	97000455	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	8145869	97000455	74114612	198	36233										
TRDN	10345	broad.mit.edu	37	chr6	123759226	123759226	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accttttttttccacatcaaTggcagtttccttctcacttt	3	12	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:123759226T>C	uc003pzj.1	-	12	1055	c.1033A>G	c.(1033-1035)ATT>GTT	p.I345V	TRDN_uc003pzk.1_Missense_Mutation_p.I346V|TRDN_uc003pzl.1_Missense_Mutation_p.I346V|uc003pzm.1_5'Flank	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	345	Lumenal.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		TCCACATCAATGGCAGTTTCC	0.338													0	0	0	0.001984	0	5	0										C	123759226	T	C	123759226	3	2	121	1	0	0	0	0	1	0	0	0	16465	1464	51	5	1276	5	TRDN	6	123759226	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	26758771	123759226	47355841	199	36234										
TRDN	10345	broad.mit.edu	37	chr6	123892184	123892185	+	Frame_Shift_Del	DEL	TC	TC	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agctgaacgtcgtcactatgTcttctgtgactgtcctcttc							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:123892184_123892185delTC	uc003pzj.1	-	2	137_138	c.115_116delGA	c.(115-117)GACfs	p.D39fs	TRDN_uc003pzk.1_Frame_Shift_Del_p.D39fs|TRDN_uc003pzl.1_Frame_Shift_Del_p.D39fs|TRDN_uc010ken.2_Frame_Shift_Del_p.D39fs|TRDN_uc010keo.1_Frame_Shift_Del_p.D39fs	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	39	Cytoplasmic.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		CGTCACTATGTCTTCTGTGACT	0.47																		29	27	---	---								-	123892185	TC	-	123892184	7	5	121	1	0	1	0	1	0	0	0	0	16465	1667	58	0	2233	0	TRDN	6	123892184	Frame_Shift_Del	DEL	TC	TCGA-GV-A3QI-01A-11D-A21Z-08	132958	123892184	47222883	200	36235										
EYA4	2070	broad.mit.edu	37	chr6	133769307	133769307	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgagttgcaacaccccctcTtctgcaacaagtatgagaga	8	12	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:133769307T>A	uc003qec.3	+	5	725	c.267T>A	c.(265-267)TCT>TCA	p.S89S	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Silent_p.S89S|EYA4_uc003qee.3_Intron|EYA4_uc011ecs.1_Silent_p.S89S|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	89					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		ACACCCCCTCTTCTGCAACAA	0.448													0	0	0	0.005524	0	28	23										A	133769307	T	A	133769307	2	1	121	1	0	0	0	0	0	0	0	1	5331	1596	56	5		5	EYA4	6	133769307	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	9877123	133769307	37345760	201	36236										
CNKSR3	154043	broad.mit.edu	37	chr6	154727695	154727695	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accagatgccgctcggtcgtGggtctggagaaccggtatgg	16	10	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:154727695G>A	uc003qpy.2	-	13	1966	c.1461C>T	c.(1459-1461)CCC>CCT	p.P487P		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3	487	DUF1170.				negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		GCTCGGTCGTGGGTCTGGAGA	0.577													0	0	0	0.002836	0	31	23										A	154727695	G	A	154727695	2	1	121	1	0	0	0	0	0	0	0	1	3608	1335	47	2		2	CNKSR3	6	154727695	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	20958388	154727695	16387372	202	36237										
ARID1B	57492	broad.mit.edu	37	chr6	157222596	157222596	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agccagcagccgcagcccccGcacctcccaccccaggcgca	9	23	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:157222596G>T	uc003qqn.2	+	3	1802	c.1650G>T	c.(1648-1650)CCG>CCT	p.P550P	ARID1B_uc003qqo.2_Silent_p.P563P|ARID1B_uc003qqp.2_Silent_p.P550P	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	608	Gln-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CGCAGCCCCCGCACCTCCCAC	0.617													1	0	3.52763e-06	0.00499	3.64248e-06	12	25										T	157222596	G	T	157222596	2	4	121	1	0	0	0	0	0	0	0	1	914	1074	38	4		4	ARID1B	6	157222596	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2494901	157222596	13892471	203	36238										
RSPH3	83861	broad.mit.edu	37	chr6	159404769	159404769	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtggtgttggtggtctgtcCaaaaatgcatctgtttggca	13	6	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:159404769C>T	uc003qrx.2	-	4	1033	c.843G>A	c.(841-843)TTG>TTA	p.L281L	RSPH3_uc010kju.2_Intron|RSPH3_uc003qry.1_Silent_p.L281L	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	281										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		GTGGTCTGTCCAAAAATGCAT	0.393													0	0	0	0.005443	0	21	30										T	159404769	C	T	159404769	2	4	121	1	0	0	0	0	0	0	0	1	13705	593	21	2		2	RSPH3	6	159404769	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2182173	159404769	11710298	204	36239										
LPA	4018	broad.mit.edu	37	chr6	161022029	161022029	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccattctgcatctgagcatCgtgtcaggttgcagtactcc	9	12	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:161022029C>A	uc003qtl.2	-	20	3167	c.3047G>T	c.(3046-3048)CGA>CTA	p.R1016L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3524	Kringle 31.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATCTGAGCATCGTGTCAGGTT	0.498													1	0	1.10513e-12	0.002299	1.20461e-12	16	16										A	161022029	C	A	161022029	3	1	121	1	0	0	0	0	1	0	0	0	8903	884	31	3	3159	3	LPA	6	161022029	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1617260	161022029	10093038	205	36240										
T	6862	broad.mit.edu	37	chr6	166571949	166571949	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agagggcgccgagaccggatGggtgaggggtgtgtagtgcg	22	6	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr6:166571949G>A	uc003quu.1	-	9	1655	c.1162C>T	c.(1162-1164)CAT>TAT	p.H388Y	T_uc003qut.1_Missense_Mutation_p.H389Y|T_uc003quv.1_Missense_Mutation_p.H330Y	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	388					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		GAGACCGGATGGGTGAGGGGT	0.716									Chordoma_Familial_Clustering_of				0	0	0	0.008871	0	14	12										A	166571949	G	A	166571949	3	1	121	1	0	0	0	0	1	0	0	0	15485	1348	47	2	149	2	T	6	166571949	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5549920	166571949	4543118	206	36241										
ICA1	3382	broad.mit.edu	37	chr7	8196838	8196838	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttctcccaaaaatgaagcaGagtggtctgcaaagaaagac	9	8	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:8196838G>C	uc003srm.2	-	8	779	c.712C>G	c.(712-714)CTG>GTG	p.L238V	ICA1_uc010ktr.2_Missense_Mutation_p.L238V|ICA1_uc003srl.2_Missense_Mutation_p.L226V|ICA1_uc003srn.3_Missense_Mutation_p.L164V|ICA1_uc003srp.3_Missense_Mutation_p.L237V|ICA1_uc010kts.2_Intron|ICA1_uc003srq.2_Missense_Mutation_p.L238V|ICA1_uc003srr.2_Missense_Mutation_p.L237V|ICA1_uc003sro.3_Missense_Mutation_p.L238V|ICA1_uc011jxg.1_Missense_Mutation_p.L238V|ICA1_uc003srs.1_Missense_Mutation_p.L238V	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	238	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		AAATGAAGCAGAGTGGTCTGC	0.393													0	0	0	0.010729	0	8	40										C	8196838	G	C	8196838	3	2	121	1	0	0	0	0	1	0	0	0	7477	933	33	1	767	1	ICA1	7	8196838	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		8196838	150941825	207	36242										
ETV1	2115	broad.mit.edu	37	chr7	14026281	14026281	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accttctgcaagccatgtttCctgtaattgacttagatctt	6	10	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:14026281C>G	uc011jxq.1	-	5	902	c.163G>C	c.(163-165)GAA>CAA	p.E55Q	ETV1_uc011jxn.1_5'Flank|ETV1_uc011jxo.1_5'Flank|ETV1_uc011jxp.1_5'Flank|ETV1_uc003ssw.3_Missense_Mutation_p.E55Q|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.E55Q|ETV1_uc011jxs.1_Missense_Mutation_p.E55Q|ETV1_uc010ktv.2_5'Flank	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	55					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						AGCCATGTTTCCTGTAATTGA	0.323			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								0	0	0	0.004482	0	6	30										G	14026281	C	G	14026281	3	3	121	1	0	0	0	0	1	0	0	0	5277	864	30	1	1375	1	ETV1	7	14026281	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5829443	14026281	145112382	208	36243										
ABCB5	340273	broad.mit.edu	37	chr7	20785059	20785059	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttttattgaaggtctccctGaggtaagaaaatttctgaaa	8	6	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:20785059G>A	uc003suw.3	+	17	2638	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	ABCB5_uc010kuh.2_Missense_Mutation_p.E1143K	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	698	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						AGGTCTCCCTGAGGTAAGAAA	0.398													0	0	0	0.008291	0	9	13										A	20785059	G	A	20785059	3	1	121	1	0	0	0	0	1	0	0	0	44	1291	45	1	3566	1	ABCB5	7	20785059	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6758778	20785059	138353604	209	36244										
DNAH11	8701	broad.mit.edu	37	chr7	21826250	21826250	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcttttcttcaggtcaacctCagtgagctgaaagcctttcc	8	12	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:21826250C>T	uc003svc.2	+	60	9658	c.9627C>T	c.(9625-9627)CTC>CTT	p.L3209L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3209	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGGTCAACCTCAGTGAGCTGA	0.517									Kartagener_syndrome				0	0	0	0.005443	0	20	42										T	21826250	C	T	21826250	2	4	121	1	0	0	0	0	0	0	0	1	4599	813	29	1		1	DNAH11	7	21826250	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1041191	21826250	137312413	210	36245										
DFNA5	1687	broad.mit.edu	37	chr7	24756952	24756952	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctgggatctccagcaccacGttggagtccttggtgacatt	12	11	1	1	rs142033677		TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:24756952G>A	uc010kus.1	-	5	706	c.618C>T	c.(616-618)AAC>AAT	p.N206N	DFNA5_uc003swz.2_Silent_p.N42N|DFNA5_uc003sxa.1_Silent_p.N206N|DFNA5_uc010kut.1_Silent_p.N42N|DFNA5_uc003sxb.2_Silent_p.N206N	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	206					sensory perception of sound					ovary(1)	1						CCAGCACCACGTTGGAGTCCT	0.582													0	0	0	0.006999	0	32	17										A	24756952	G	A	24756952	2	1	121	1	0	0	0	0	0	0	0	1	4454	1136	40	2		2	DFNA5	7	24756952	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2930702	24756952	134381711	211	36246										
CREB5	9586	broad.mit.edu	37	chr7	28763907	28763907	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccaaatctcagcaacccctgTgcttctccccaggtccagcc	6	19	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:28763907T>A	uc003szq.2	+	7	1050	c.660T>A	c.(658-660)TGT>TGA	p.C220*	CREB5_uc003szo.2_Nonsense_Mutation_p.C187*|CREB5_uc003szr.2_Nonsense_Mutation_p.C213*|CREB5_uc003szs.2_Nonsense_Mutation_p.C81*|CREB5_uc011jzr.1_Nonsense_Mutation_p.C69*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	220					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GCAACCCCTGTGCTTCTCCCC	0.408													0	0	0	0.006122	0	12	27										A	28763907	T	A	28763907	4	1	121	1	0	0	0	0	0	1	0	0	3860	1702	59	5	737	5	CREB5	7	28763907	Nonsense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	4006955	28763907	130374756	212	36247										
FAM188B	84182	broad.mit.edu	37	chr7	30831104	30831104	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gacaggatgcccttgaagctCtacttgcctggtggtaattc	11	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:30831104C>G	uc003tbt.2	+	5	1064	c.987C>G	c.(985-987)CTC>CTG	p.L329L	FAM188B_uc010kwe.2_Silent_p.L300L	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	329											0						CCTTGAAGCTCTACTTGCCTG	0.627													0	0	0	0.001368	0	10	35										G	30831104	C	G	30831104	2	3	121	1	0	0	0	0	0	0	0	1	5515	900	32	1		1	FAM188B	7	30831104	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2067197	30831104	128307559	213	36248										
GHRHR	2692	broad.mit.edu	37	chr7	31014105	31014105	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctggccttcgaggacatcgcGtgagtcggagcggccacctt	14	13	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:31014105G>A	uc003tbx.2	+	8	860	c.812_splice	c.e8+1	p.A271_splice	GHRHR_uc003tbw.1_Splice_Site_p.A271_splice|GHRHR_uc003tby.2_Splice_Site_p.A207_splice|GHRHR_uc003tbz.2_Splice_Site_p.R37_splice	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor						activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	AGGACATCGCGTGAGTCGGAG	0.617													0	0	0	0.010818	0	25	71										A	31014105	G	A	31014105	5	1	121	1	0	0	0	0	0	0	1	0	6373	1159	40	2	843	2	GHRHR	7	31014105	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	183001	31014105	128124558	214	36249										
POU6F2	11281	broad.mit.edu	37	chr7	39247149	39247149	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgccaacagcgaatctcacCaacatccaagggctggtggc	10	14	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:39247149C>A	uc003thb.1	+	4	483	c.441C>A	c.(439-441)ACC>ACA	p.T147T	POU6F2_uc010kxo.2_Silent_p.T139T	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	147					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CGAATCTCACCAACATCCAAG	0.552													1	0	3.52763e-06	0.00499	3.64248e-06	17	26										A	39247149	C	A	39247149	2	1	121	1	0	0	0	0	0	0	0	1	12285	581	21	4		4	POU6F2	7	39247149	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	8233044	39247149	119891514	215	36250										
TNS3	64759	broad.mit.edu	37	chr7	47408849	47408849	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccttcagagcagcgtctccaTtcacgtgaacctgggctggc	11	14	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:47408849T>A	uc003tnv.2	-	17	1761	c.1394A>T	c.(1393-1395)AAT>ATT	p.N465I	TNS3_uc003tnw.2_Missense_Mutation_p.N465I	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	465						focal adhesion	protein binding			ovary(4)	4						AGCGTCTCCATTCACGTGAAC	0.582													0	0	0	0.00333	0	18	24										A	47408849	T	A	47408849	3	1	121	1	0	0	0	0	1	0	0	0	16341	1493	52	5	3003	5	TNS3	7	47408849	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	8161700	47408849	111729814	216	36251										
C7orf57	136288	broad.mit.edu	37	chr7	48081010	48081010	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcccagatcccaggtctcagCaatttgggagactcacacag	9	13	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:48081010C>T	uc003toh.3	+	3	347	c.135C>T	c.(133-135)AGC>AGT	p.S45S	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	45										ovary(1)	1						CAGGTCTCAGCAATTTGGGAG	0.537													0	0	0	0.004007	0	13	23										T	48081010	C	T	48081010	2	4	121	1	0	0	0	0	0	0	0	1	2404	709	25	2		2	C7orf57	7	48081010	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	672161	48081010	111057653	217	36252										
ABCA13	154664	broad.mit.edu	37	chr7	48316091	48316091	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acattcttctccctttttctAaaggaagattctgagaacaa	5	9	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:48316091A>G	uc003toq.2	+	17	6853	c.6828A>G	c.(6826-6828)CTA>CTG	p.L2276L	ABCA13_uc010kyr.2_Silent_p.L1779L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2276					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CCCTTTTTCTAAAGGAAGATT	0.343													0	0	0	0.001855	0	12	8										G	48316091	A	G	48316091	2	3	121	1	0	0	0	0	0	0	0	1	31	349	13	5		5	ABCA13	7	48316091	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	235081	48316091	110822572	218	36253										
IKZF1	10320	broad.mit.edu	37	chr7	50468169	50468169	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tacaagtgcgaacactgccgGgtgctcttcctggatcacgt	11	12	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:50468169G>T	uc003tow.3	+	9	1572	c.1404G>T	c.(1402-1404)CGG>CGT	p.R468R	IKZF1_uc003tox.3_Silent_p.R426R|IKZF1_uc003toy.3_Silent_p.R426R|IKZF1_uc011kck.1_Silent_p.R381R|IKZF1_uc003toz.3_Silent_p.R438R|IKZF1_uc010kyx.2_Silent_p.R208R|IKZF1_uc003tpa.3_Silent_p.R210R	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	468	C2H2-type 5.|Required for binding PP1CC (By similarity).				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AACACTGCCGGGTGCTCTTCC	0.622			D		ALL								1	0	3.11337e-16	0.002836	3.47904e-16	22	14										T	50468169	G	T	50468169	2	4	121	1	0	0	0	0	0	0	0	1	7614	1219	43	4		4	IKZF1	7	50468169	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2152078	50468169	108670494	219	36254										
POM121L12	285877	broad.mit.edu	37	chr7	53103682	53103682	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctgcccttcccggggagacCgctctggggcgagacctctc	13	17	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:53103682C>G	uc003tpz.2	+	1	334	c.318C>G	c.(316-318)ACC>ACG	p.T106T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	106											0						CCGGGGAGACCGCTCTGGGGC	0.711													0	0	0	0.004482	0	8	15										G	53103682	C	G	53103682	2	3	121	1	0	0	0	0	0	0	0	1	12241	639	23	4		4	POM121L12	7	53103682	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2635513	53103682	106034981	220	36255										
ZNF713	349075	broad.mit.edu	37	chr7	56006860	56006860	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaaaccacaagagatatttaGgacaagtaactttgacccac	6	9	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:56006860G>A	uc003trc.1	+	4	492	c.454G>A	c.(454-456)GGA>AGA	p.G152R	ZNF713_uc003tra.1_Missense_Mutation_p.G165R|MRPS17_uc003trb.2_Intron	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAGATATTTAGGACAAGTAAC	0.413													0	0	0	0.004007	0	12	11										A	56006860	G	A	56006860	3	1	121	1	0	0	0	0	1	0	0	0	18114	1001	35	2	468	2	ZNF713	7	56006860	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2903178	56006860	103131803	221	36256										
ZNF679	168417	broad.mit.edu	37	chr7	63721301	63721301	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaaatgagatggtaaccaaaCacccaggtaagtgagagtgg	13	6	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:63721301C>T	uc003tsx.2	+	4	525	c.256C>T	c.(256-258)CAC>TAC	p.H86Y		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	86	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GGTAACCAAACACCCAGGTAA	0.428													0	0	0	0.004672	0	3	21										T	63721301	C	T	63721301	3	4	121	1	0	0	0	0	1	0	0	0	18083	478	17	2	266	2	ZNF679	7	63721301	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7714441	63721301	95417362	222	36257										
SRRM3	222183	broad.mit.edu	37	chr7	75890733	75890733	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagaagcatcgccgagacagGtacccttgctgcccccaccc	9	17	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:75890733G>A	uc010ldi.2	+	7	847	c.638_splice	c.e7+1	p.R213_splice		NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0						GCCGAGACAGGTACCCTTGCT	0.667													0	0	0	0.002299	0	16	1										A	75890733	G	A	75890733	5	1	121	1	0	0	0	0	0	0	1	0	15169	1275	44	2	661	2	SRRM3	7	75890733	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	12169432	75890733	83247930	223	36258										
PION	54103	broad.mit.edu	37	chr7	76950709	76950709	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttggtttctacgatgtggcaAatgagatccagctggagggt	14	6	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:76950709A>G	uc003ugf.2	-	25	2014	c.1935T>C	c.(1933-1935)ATT>ATC	p.I645I	PION_uc011kgo.1_Intron|PION_uc003ugd.2_Silent_p.I39I	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	645					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						CGATGTGGCAAATGAGATCCA	0.453													0	0	0	0.00308	0	4	86										G	76950709	A	G	76950709	2	3	121	1	0	0	0	0	0	0	0	1	11934	10	1	5		5	PION	7	76950709	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1059976	76950709	82187954	224	36259										
MTERF	7978	broad.mit.edu	37	chr7	91503775	91503775	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgctagctcctttggaaagAaggaacatcttcaggtcctg	10	9	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:91503775A>T	uc003ulb.1	-	2	377	c.333T>A	c.(331-333)CTT>CTA	p.L111L	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Silent_p.L111L|MTERF_uc011khm.1_Silent_p.L91L|MTERF_uc010leu.1_Silent_p.L91L	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	111					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			CTTTGGAAAGAAGGAACATCT	0.428													0	0	0	0.00361	0	93	40										T	91503775	A	T	91503775	2	4	121	1	0	0	0	0	0	0	0	1	9918	233	9	5		5	MTERF	7	91503775	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	14553066	91503775	67634888	225	36260										
NPTX2	4885	broad.mit.edu	37	chr7	98256632	98256632	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caccccatcaagcccgggggCgtgctgatccttggacaaga	12	14	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:98256632C>T	uc003upl.2	+	4	1221	c.1044C>T	c.(1042-1044)GGC>GGT	p.G348G		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	348	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			AGCCCGGGGGCGTGCTGATCC	0.677													0	0	0	0.00361	0	53	11										T	98256632	C	T	98256632	2	4	121	1	0	0	0	0	0	0	0	1	10603	755	27	2		2	NPTX2	7	98256632	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6752857	98256632	60882031	226	36261										
ZNF394	84124	broad.mit.edu	37	chr7	99097527	99097527	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagctgcctaaagtgcagtcGagaagtttcggggtccggcg	15	10	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:99097527G>A	uc003uqs.2	-	1	351	c.190C>T	c.(190-192)CGA>TGA	p.R64*	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Nonsense_Mutation_p.R64*	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	64	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAGTGCAGTCGAGAAGTTTCG	0.627													0	0	0	0.001984	0	7	46										A	99097527	G	A	99097527	4	1	121	1	0	0	0	0	0	1	0	0	17877	1066	37	1	1507	1	ZNF394	7	99097527	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	840895	99097527	60041136	227	36262										
GIGYF1	64599	broad.mit.edu	37	chr7	100280767	100280767	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcttggccaggccagcccaGagtgggggcggggagctggg	21	10	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:100280767G>C	uc003uwg.1	-	19	3289	c.2280C>G	c.(2278-2280)CTC>CTG	p.L760L		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	760										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GGCCAGCCCAGAGTGGGGGCG	0.677													0	0	0	0.006214	0	8	1										C	100280767	G	C	100280767	2	2	121	1	0	0	0	0	0	0	0	1	6377	929	33	1		1	GIGYF1	7	100280767	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1183240	100280767	58857896	228	36263										
MUC17	140453	broad.mit.edu	37	chr7	100684490	100684490	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagccagttcatctcctcccActgctgaaggtaccagcatg	8	14	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:100684490A>G	uc003uxp.1	+	3	9846	c.9793A>G	c.(9793-9795)ACT>GCT	p.T3265A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3265	Extracellular (Potential).|Ser-rich.|53.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATCTCCTCCCACTGCTGAAGG	0.517													0	0	0	0.00361	0	516	155										G	100684490	A	G	100684490	3	3	121	1	0	0	0	0	1	0	0	0	9974	159	6	5	9803	5	MUC17	7	100684490	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	403723	100684490	58454173	229	36264										
NAPEPLD	222236	broad.mit.edu	37	chr7	102743924	102743924	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tatcttgattctccatgcttCaagacaaaaaaatcttcagc	4	10	5	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:102743924C>G	uc003vbc.2	-	5	1462	c.1134G>C	c.(1132-1134)TTG>TTC	p.L378F	NAPEPLD_uc003vbd.2_Missense_Mutation_p.L378F|NAPEPLD_uc011klj.1_Missense_Mutation_p.L451F|NAPEPLD_uc003vbe.2_RNA	NM_198990	NP_945341	Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	378					phospholipid catabolic process	membrane	metal ion binding			skin(1)	1						CTCCATGCTTCAAGACAAAAA	0.348													0	0	0	0.003163	0	14	7										G	102743924	C	G	102743924	3	3	121	1	0	0	0	0	1	0	0	0	10163	825	29	1	51	1	NAPEPLD	7	102743924	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2059434	102743924	56394739	230	36265										
MLL5	55904	broad.mit.edu	37	chr7	104731675	104731675	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttttcaggaaccagattttAttgatgatatagaagaaaaa	7	3	1	5			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:104731675A>G	uc003vcm.2	+	15	2170	c.1636A>G	c.(1636-1638)ATT>GTT	p.I546V	MLL5_uc003vcl.2_Missense_Mutation_p.I546V|MLL5_uc010ljc.2_Missense_Mutation_p.I546V	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	546					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACCAGATTTTATTGATGATAT	0.318													0	0	0	0.004672	0	3	10										G	104731675	A	G	104731675	3	3	121	1	0	0	0	0	1	0	0	0	9624	449	16	5	1686	5	MLL5	7	104731675	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1987751	104731675	54406988	231	36266										
CADPS2	93664	broad.mit.edu	37	chr7	122377026	122377026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tacctcataataactccgaaCtgcgttgcaaaatgcttcgt	6	11	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:122377026C>T	uc010lkp.2	-	2	599	c.436G>A	c.(436-438)GTT>ATT	p.V146I	CADPS2_uc010lkq.2_Missense_Mutation_p.V146I	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	146					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TAACTCCGAACTGCGTTGCAA	0.378													0	0	0	0.001855	0	10	16										T	122377026	C	T	122377026	3	4	121	1	0	0	0	0	1	0	0	0	2571	565	20	2	3614	2	CADPS2	7	122377026	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17645351	122377026	36761637	232	36267										
AHCYL2	23382	broad.mit.edu	37	chr7	129040163	129040163	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgcctggaagggagagtcaGaagatgacttttggtggtgt	16	4	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:129040163G>C	uc011kov.1	+	6	910	c.856G>C	c.(856-858)GAA>CAA	p.E286Q	AHCYL2_uc003vot.2_Missense_Mutation_p.E285Q|AHCYL2_uc003vov.2_Missense_Mutation_p.E183Q|AHCYL2_uc011kow.1_Missense_Mutation_p.E184Q|AHCYL2_uc011kox.1_Missense_Mutation_p.E183Q	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	286					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GGGAGAGTCAGAAGATGACTT	0.448													0	0	0	0.002299	0	19	43										C	129040163	G	C	129040163	3	2	121	1	0	0	0	0	1	0	0	0	411	943	33	1	1000	1	AHCYL2	7	129040163	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6663137	129040163	30098500	233	36268										
LRGUK	136332	broad.mit.edu	37	chr7	133812382	133812382	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcgagggcgaggcgggatccGaggagtcctcagagtccgaa	18	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:133812382G>A	uc003vrm.1	+	1	278	c.262G>A	c.(262-264)GAG>AAG	p.E88K		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	88							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GGCGGGATCCGAGGAGTCCTC	0.617													0	0	0	0.012213	0	22	39										A	133812382	G	A	133812382	3	1	121	1	0	0	0	0	1	0	0	0	8943	1059	37	1	264	1	LRGUK	7	133812382	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4772219	133812382	25326281	234	36269										
SMARCD3	6604	broad.mit.edu	37	chr7	150939810	150939810	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccccgaactaaggcaccttCatgggcctcttcagagcctc	8	17	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:150939810C>T	uc003wjs.2	-	4	554	c.453G>A	c.(451-453)ATG>ATA	p.M151I	SMARCD3_uc003wjt.2_Missense_Mutation_p.M138I|SMARCD3_uc003wju.2_Missense_Mutation_p.M138I|SMARCD3_uc011kvh.1_Missense_Mutation_p.M151I|SMARCD3_uc010lqa.1_Missense_Mutation_p.M151I	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	151					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAGGCACCTTCATGGGCCTCT	0.577													0	0	0	0.00361	0	54	127										T	150939810	C	T	150939810	3	4	121	1	0	0	0	0	1	0	0	0	14779	826	29	1	1038	1	SMARCD3	7	150939810	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17127428	150939810	8198853	235	36270										
DPP6	1804	broad.mit.edu	37	chr7	154598703	154598703	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgcgtcctttgctcttccaGtgccaacacggtgggcaact	10	14	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:154598703G>T	uc003wlk.2	+	16	1677	c.1548_splice	c.e16-1	p.S516_splice	DPP6_uc003wli.2_Splice_Site_p.S452_splice|DPP6_uc003wlm.2_Splice_Site_p.S454_splice|DPP6_uc011kvq.1_Splice_Site_p.S409_splice	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1						cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGCTCTTCCAGTGCCAACACG	0.597													1	0	2.04263e-09	0.004289	2.16969e-09	33	54										T	154598703	G	T	154598703	5	4	121	1	0	0	0	0	0	0	1	0	4730	1043	36	4	1725	4	DPP6	7	154598703	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3658893	154598703	4539960	236	36271										
VIPR2	7434	broad.mit.edu	37	chr7	158851235	158851235	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagagacactgtagcccagtGtataaatggccttcaccaga	10	10	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr7:158851235G>T	uc003woh.2	-	5	578	c.392C>A	c.(391-393)ACC>AAC	p.T131N	VIPR2_uc010lqx.2_RNA|VIPR2_uc010lqy.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	131	Helical; Name=1; (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		GTAGCCCAGTGTATAAATGGC	0.413													1	0	2.19489e-29	0.00623	2.55559e-29	27	58										T	158851235	G	T	158851235	3	4	121	1	0	0	0	0	1	0	0	0	17167	1377	48	4	960	4	VIPR2	7	158851235	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4252532	158851235	287428	237	36272										
PTK2B	2185	broad.mit.edu	37	chr8	27277583	27277583	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtgtctgcacgtggaagccGagtggaggtaggagtggatt	18	5	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:27277583G>A	uc003xfn.1	+	8	1184	c.376G>A	c.(376-378)GAG>AAG	p.E126K	PTK2B_uc003xfo.1_Missense_Mutation_p.E126K|PTK2B_uc003xfp.1_Missense_Mutation_p.E126K|PTK2B_uc003xfq.1_Missense_Mutation_p.E126K	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	126	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CGTGGAAGCCGAGTGGAGGTA	0.582													0	0	0	0.00623	0	29	26										A	27277583	G	A	27277583	3	1	121	1	0	0	0	0	1	0	0	0	12763	1059	37	1	382	1	PTK2B	8	27277583	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		27277583	119086439	238	36273										
ANK1	286	broad.mit.edu	37	chr8	41525865	41525865	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctccggtccctgtcggcctGggagctctcagcctcgggct	13	17	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:41525865G>T	uc003xok.2	-	39	5398	c.5314C>A	c.(5314-5316)CAG>AAG	p.Q1772K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.Q926K|ANK1_uc003xoi.2_Missense_Mutation_p.Q1772K|ANK1_uc003xoj.2_Missense_Mutation_p.Q1772K|ANK1_uc003xol.2_Missense_Mutation_p.Q1610K|ANK1_uc003xom.2_Missense_Mutation_p.Q1813K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1772	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTGTCGGCCTGGGAGCTCTCA	0.617													1	0	1.61788e-16	0.012213	1.81094e-16	29	22										T	41525865	G	T	41525865	3	4	121	1	0	0	0	0	1	0	0	0	620	1357	47	4	673	4	ANK1	8	41525865	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	14248282	41525865	104838157	239	36274										
PRKDC	5591	broad.mit.edu	37	chr8	48694764	48694764	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcttgggacatggtgttcaaAagaaggtccttcaaggtaac	11	7	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:48694764A>G	uc003xqi.2	-	81	11505	c.11448T>C	c.(11446-11448)CTT>CTC	p.L3816L	PRKDC_uc003xqj.2_Intron|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3816	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGGTGTTCAAAAGAAGGTCCT	0.502								NHEJ					0	0	0	0.004482	0	8	50										G	48694764	A	G	48694764	2	3	121	1	0	0	0	0	0	0	0	1	12521	1	1	5		5	PRKDC	8	48694764	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	7168899	48694764	97669258	240	36275										
SLCO5A1	81796	broad.mit.edu	37	chr8	70744123	70744123	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caaatgaataaagccacgtaGacccagtgattatttcctcc	6	11	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:70744123G>T	uc003xyl.2	-	2	1493	c.786C>A	c.(784-786)GTC>GTA	p.V262V	SLCO5A1_uc010lzb.2_Silent_p.V262V|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Silent_p.V262V|SLCO5A1_uc010lzc.2_Silent_p.V262V	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	262	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AAGCCACGTAGACCCAGTGAT	0.542													1	0	1.05386e-31	0.00361	1.23568e-31	40	16										T	70744123	G	T	70744123	2	4	121	1	0	0	0	0	0	0	0	1	14731	929	33	3		3	SLCO5A1	8	70744123	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	22049359	70744123	75619899	241	36276										
TRPA1	8989	broad.mit.edu	37	chr8	72981302	72981302	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgcacagctatgtggagagGagccatcatgttgaagtttc	12	8	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:72981302G>A	uc003xza.2	-	3	575	c.400C>T	c.(400-402)CCT>TCT	p.P134S		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	134	Cytoplasmic (Potential).|ANK 3.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	ATGTGGAGAGGAGCCATCATG	0.512													0	0	0	0.00361	0	110	190										A	72981302	G	A	72981302	3	1	121	1	0	0	0	0	1	0	0	0	16574	1174	41	1	3059	1	TRPA1	8	72981302	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2237179	72981302	73382720	242	36277										
ZFHX4	79776	broad.mit.edu	37	chr8	77765656	77765656	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggaaatggcagagaaatctGgcctctcccaaaaagttatc	9	9	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:77765656G>T	uc003yav.2	+	10	6751	c.6364G>T	c.(6364-6366)GGC>TGC	p.G2122C	ZFHX4_uc003yau.1_Missense_Mutation_p.G2167C|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2122C	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2122	Homeobox 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGAGAAATCTGGCCTCTCCCA	0.368										HNSCC(33;0.089)			1	0	4.96729e-08	0.008871	5.20979e-08	19	17										T	77765656	G	T	77765656	3	4	121	1	0	0	0	0	1	0	0	0	17632	1348	47	4	6533	4	ZFHX4	8	77765656	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4784354	77765656	68598366	243	36278										
RUNX1T1	862	broad.mit.edu	37	chr8	93004034	93004034	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agccgttatttggactgtacCgctggcctgggctaatagtg	13	9	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:93004034C>A	uc003yfd.2	-	6	908	c.824G>T	c.(823-825)CGG>CTG	p.R275L	RUNX1T1_uc003yfc.1_Missense_Mutation_p.R248L|RUNX1T1_uc003yfe.1_Missense_Mutation_p.R238L|RUNX1T1_uc010mao.2_Missense_Mutation_p.R248L|RUNX1T1_uc011lgi.1_Missense_Mutation_p.R286L|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.R238L	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	275					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGGACTGTACCGCTGGCCTGG	0.512													1	0	4.87955e-14	0.005443	5.37154e-14	22	23										A	93004034	C	A	93004034	3	1	121	1	0	0	0	0	1	0	0	0	13747	652	23	4	1014	4	RUNX1T1	8	93004034	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	15238378	93004034	53359988	244	36279										
PKHD1L1	93035	broad.mit.edu	37	chr8	110410761	110410761	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccccccaaacctcatattctCaaaactgtatatccaggtaa	3	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:110410761C>G	uc003yne.2	+	12	1100	c.996C>G	c.(994-996)CTC>CTG	p.L332L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	332	Extracellular (Potential).|IPT/TIG 3.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTCATATTCTCAAAACTGTAT	0.294										HNSCC(38;0.096)			0	0	0	0.00308	0	5	12										G	110410761	C	G	110410761	2	3	121	1	0	0	0	0	0	0	0	1	11972	813	29	1		1	PKHD1L1	8	110410761	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17406727	110410761	35953261	245	36280										
CSMD3	114788	broad.mit.edu	37	chr8	113299303	113299303	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgagattacctttgcactcTggctgccttccggtccaact	8	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:113299303T>C	uc003ynu.2	-	58	9480	c.9321A>G	c.(9319-9321)CCA>CCG	p.P3107P	CSMD3_uc003yns.2_Silent_p.P2309P|CSMD3_uc003ynt.2_Silent_p.P3067P|CSMD3_uc011lhx.1_Silent_p.P2938P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3107	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTTGCACTCTGGCTGCCTTC	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.00308	0	6	133										C	113299303	T	C	113299303	2	2	121	1	0	0	0	0	0	0	0	1	3946	1567	55	5		5	CSMD3	8	113299303	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2888542	113299303	33064719	246	36281										
KCNK9	51305	broad.mit.edu	37	chr8	140715046	140715046	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttccgactgcaggatcaccaGctccagctgccggtagtcct	10	15	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:140715046G>A	uc003yvf.1	-	1	254	c.190C>T	c.(190-192)CTG>TTG	p.L64L	KCNK9_uc003yvg.1_Silent_p.L64L	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	64	Extracellular (Potential).					integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			ovary(2)|lung(1)	3	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			AGGATCACCAGCTCCAGCTGC	0.597													0	0	0	0.00333	0	21	27										A	140715046	G	A	140715046	2	1	121	1	0	0	0	0	0	0	0	1	8072	962	34	2		2	KCNK9	8	140715046	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	27415743	140715046	5648976	247	36282										
CHRAC1	54108	broad.mit.edu	37	chr8	141524510	141524510	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccacctattcctacagacacGgcagtggaaaggaaaagaaa	9	10	0	2	rs143839289		TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:141524510G>T	uc003yvl.2	+	2	388	c.190G>T	c.(190-192)GGC>TGC	p.G64C	CHRAC1_uc010mem.1_Intron	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1	64					chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			CTACAGACACGGCAGTGGAAA	0.383													1	0	7.41945e-09	0.005443	7.8186e-09	19	11										T	141524510	G	T	141524510	3	4	121	1	0	0	0	0	1	0	0	0	3371	1116	39	4	196	4	CHRAC1	8	141524510	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	809464	141524510	4839512	248	36283										
PTP4A3	11156	broad.mit.edu	37	chr8	142441037	142441037	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcttcccaggaagcgccgcGgagccatcaacagcaagcag	11	15	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:142441037G>T	uc003ywg.1	+	5	749	c.415G>T	c.(415-417)GGA>TGA	p.G139*	PTP4A3_uc003ywh.1_Nonsense_Mutation_p.G114*|PTP4A3_uc010met.1_Silent_p.A52A	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	139	Tyrosine-protein phosphatase.					early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			GAAGCGCCGCGGAGCCATCAA	0.597													1	0	1.96292e-10	0.010504	2.10516e-10	17	23										T	142441037	G	T	142441037	4	4	121	1	0	0	0	0	0	1	0	0	12772	1117	39	4	433	4	PTP4A3	8	142441037	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	916527	142441037	3922985	249	36284										
PPP1R16A	84988	broad.mit.edu	37	chr8	145727093	145727093	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctgaagcgccagcgagctgCtgccaagctgcagcgacccc	12	17	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr8:145727093C>T	uc003zdd.2	+	11	2307	c.1394C>T	c.(1393-1395)GCT>GTT	p.A465V	uc003zde.1_5'Flank|PPP1R16A_uc003zdf.2_Missense_Mutation_p.A465V|GPT_uc011lli.1_5'Flank|GPT_uc011llj.1_5'Flank|GPT_uc003zdh.3_5'Flank	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	465						plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CAGCGAGCTGCTGCCAAGCTG	0.692													0	0	0	0.001984	0	5	7										T	145727093	C	T	145727093	3	4	121	1	0	0	0	0	1	0	0	0	12365	797	28	2	1432	2	PPP1R16A	8	145727093	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3286056	145727093	636929	250	36285										
MPDZ	8777	broad.mit.edu	37	chr9	13107098	13107098	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccttttcagacgtccgtcttCagaggctgctccctgcaaat	8	14	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:13107098C>T	uc010mhy.2	-	45	6043	c.5992G>A	c.(5992-5994)GAA>AAA	p.E1998K	MPDZ_uc003zkx.3_Missense_Mutation_p.E222K|MPDZ_uc003zky.3_Missense_Mutation_p.E561K|MPDZ_uc010mib.2_Missense_Mutation_p.E732K|MPDZ_uc010mhx.2_Missense_Mutation_p.E849K|MPDZ_uc011lmm.1_Missense_Mutation_p.E886K|MPDZ_uc003zkz.3_Missense_Mutation_p.E720K|MPDZ_uc010mhz.2_Missense_Mutation_p.E1994K|MPDZ_uc011lmn.1_Missense_Mutation_p.E1965K|MPDZ_uc003zlb.3_Missense_Mutation_p.E1998K	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	2027	PDZ 13.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CGTCCGTCTTCAGAGGCTGCT	0.433													0	0	0	0.003954	0	21	90										T	13107098	C	T	13107098	3	4	121	1	0	0	0	0	1	0	0	0	9722	835	29	1	137	1	MPDZ	9	13107098	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		13107098	128106333	251	36286										
CER1	9350	broad.mit.edu	37	chr9	14720287	14720287	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtgagagcaggaggtatggGagtgctgcgcggctccagga	19	7	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:14720287G>T	uc003zlj.2	-	2	650	c.605C>A	c.(604-606)TCC>TAC	p.S202Y		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	202	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		GGAGGTATGGGAGTGCTGCGC	0.502													1	0	1.80694e-10	0.009535	1.94101e-10	25	98										T	14720287	G	T	14720287	3	4	121	1	0	0	0	0	1	0	0	0	3265	1174	41	3	202	3	CER1	9	14720287	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1613189	14720287	126493144	252	36287										
TOPORS	10210	broad.mit.edu	37	chr9	32544067	32544067	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgaagtcatcttctgccctCacagaatggaaaatagaatc	7	9	4	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:32544067C>T	uc003zrb.2	-	3	623	c.456G>A	c.(454-456)GTG>GTA	p.V152V	TOPORS_uc003zrc.2_Silent_p.V85V	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	152	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CTTCTGCCCTCACAGAATGGA	0.428													0	0	0	0.00333	0	22	72										T	32544067	C	T	32544067	2	4	121	1	0	0	0	0	0	0	0	1	16367	813	29	1		1	TOPORS	9	32544067	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17823780	32544067	108669364	253	36288										
DNAI1	27019	broad.mit.edu	37	chr9	34514538	34514538	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagatctgggaccacaccatCaagtgaggggcctgttcctg	12	11	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:34514538C>G	uc003zum.2	+	17	1909	c.1716C>G	c.(1714-1716)ATC>ATG	p.I572M		NM_012144	NP_036276	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	572	WD 3.				cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		ACCACACCATCAAGTGAGGGG	0.597									Kartagener_syndrome				0	0	0	0.00361	0	56	42										G	34514538	C	G	34514538	3	3	121	1	0	0	0	0	1	0	0	0	4609	816	29	1	1782	1	DNAI1	9	34514538	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1970471	34514538	106698893	254	36289										
PIGO	84720	broad.mit.edu	37	chr9	35090170	35090170	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catcagtggctcctcttcctCctcgggtctgactctggcat	9	15	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:35090170C>G	uc003zwd.2	-	9	3358	c.2962G>C	c.(2962-2964)GAG>CAG	p.E988Q	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Missense_Mutation_p.E571Q|PIGO_uc003zwf.2_Missense_Mutation_p.E571Q|PIGO_uc003zwg.1_3'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	988					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCCTCTTCCTCCTCGGGTCTG	0.597													0	0	0	0.001368	0	13	53										G	35090170	C	G	35090170	3	3	121	1	0	0	0	0	1	0	0	0	11894	864	30	1	319	1	PIGO	9	35090170	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	575632	35090170	106123261	255	36290										
NPR2	4882	broad.mit.edu	37	chr9	35792645	35792645	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcctgctctgagtacctggcAccgctgagcgctgtggacct	13	14	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:35792645A>G	uc003zyd.2	+	1	240	c.240A>G	c.(238-240)GCA>GCG	p.A80A	NPR2_uc010mlb.2_Silent_p.A80A	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	80	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	AGTACCTGGCACCGCTGAGCG	0.657													0	0	0	0.008871	0	16	105										G	35792645	A	G	35792645	2	3	121	1	0	0	0	0	0	0	0	1	10595	146	6	5		5	NPR2	9	35792645	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	702475	35792645	105420786	256	36291										
FRMPD1	22844	broad.mit.edu	37	chr9	37745551	37745551	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acagggaccgagcagatcccAccacatccccctagagaccc	8	18	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:37745551A>T	uc004aag.1	+	16	3566	c.3522A>T	c.(3520-3522)CCA>CCT	p.P1174P	FRMPD1_uc004aah.1_Silent_p.P1174P	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1174						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		AGCAGATCCCACCACATCCCC	0.478													0	0	0	0.001168	0	6	25										T	37745551	A	T	37745551	2	4	121	1	0	0	0	0	0	0	0	1	6057	146	6	5		5	FRMPD1	9	37745551	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1952906	37745551	103467880	257	36292										
FAM75A6	389730	broad.mit.edu	37	chr9	43627203	43627203	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagactgaagatgggcctgaGcctcggcctgagccataggt	14	10	0	5			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:43627203G>T	uc011lrb.1	-	4	1513	c.1484C>A	c.(1483-1485)GCT>GAT	p.A495D		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	495						integral to membrane					0						ATGGGCCTGAGCCTCGGCCTG	0.542													1	0	1.06012e-137	0.00361	1.27214e-137	277	449										T	43627203	G	T	43627203	3	4	121	1	0	0	0	0	1	0	0	0	5622	971	34	4	2551	4	FAM75A6	9	43627203	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5881652	43627203	97586228	258	36293										
PTAR1	375743	broad.mit.edu	37	chr9	72333393	72333393	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agggagtctggaactggcgtCcgcttcaggcgtttggtttc	15	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:72333393C>A	uc004ahj.3	-	8	1096	c.1074G>T	c.(1072-1074)CGG>CGT	p.R358R	PTAR1_uc004ahi.2_Silent_p.R306R	NM_001099666	NP_001093136	Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat	358					protein prenylation		protein prenyltransferase activity			central_nervous_system(1)	1						GAACTGGCGTCCGCTTCAGGC	0.522													1	0	2.39556e-15	0.00278	2.65908e-15	19	20										A	72333393	C	A	72333393	2	1	121	1	0	0	0	0	0	0	0	1	12724	842	30	3		3	PTAR1	9	72333393	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	28706190	72333393	68880038	259	36294										
GNA14	9630	broad.mit.edu	37	chr9	80043925	80043925	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgaatccacttccgtctttcCgatcgttggccaccaacatc	6	15	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:80043925C>T	uc004aku.2	-	5	1144	c.621G>A	c.(619-621)TCG>TCA	p.S207S		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	207					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TCCGTCTTTCCGATCGTTGGC	0.453													0	0	0	0.00361	0	112	71										T	80043925	C	T	80043925	2	4	121	1	0	0	0	0	0	0	0	1	6502	639	23	2		2	GNA14	9	80043925	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7710532	80043925	61169506	260	36295										
TLE1	7088	broad.mit.edu	37	chr9	84230944	84230944	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtggaacttgccgaggaggCcgtggaagctggactgctag	17	8	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:84230944C>T	uc004aly.2	-	11	1312	c.871G>A	c.(871-873)GCC>ACC	p.A291T	TLE1_uc004alz.2_Missense_Mutation_p.A301T|TLE1_uc011lsr.1_Missense_Mutation_p.A291T|TLE1_uc004ama.1_Missense_Mutation_p.A291T|TLE1_uc011lss.1_Missense_Mutation_p.A217T	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	291	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GCCGAGGAGGCCGTGGAAGCT	0.488													0	0	0	0.004289	0	32	16										T	84230944	C	T	84230944	3	4	121	1	0	0	0	0	1	0	0	0	15935	739	26	2	1481	2	TLE1	9	84230944	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	4187019	84230944	56982487	261	36296										
KIF27	55582	broad.mit.edu	37	chr9	86518142	86518142	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgttgctgcttttcgtttaGtctgacagtatcttttaggt	10	6	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:86518142G>A	uc004ana.2	-	4	1435	c.1291C>T	c.(1291-1293)CTA>TTA	p.L431L	KIF27_uc010mpw.2_Silent_p.L431L|KIF27_uc010mpx.2_Silent_p.L431L	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	431					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TTTTCGTTTAGTCTGACAGTA	0.473													0	0	0	0.001368	0	10	21										A	86518142	G	A	86518142	2	1	121	1	0	0	0	0	0	0	0	1	8296	1020	36	2		2	KIF27	9	86518142	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2287198	86518142	54695289	262	36297										
DAPK1	1612	broad.mit.edu	37	chr9	90266558	90266558	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggcacggcaatactcccctCcatgtggcatgtaaagatgg	11	11	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:90266558C>T	uc004apc.2	+	17	1881	c.1743C>T	c.(1741-1743)CTC>CTT	p.L581L	DAPK1_uc004apd.2_Silent_p.L581L|DAPK1_uc011ltg.1_Silent_p.L581L|DAPK1_uc011lth.1_Silent_p.L318L|DAPK1_uc004apf.1_Silent_p.L135L	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	581	ANK 7.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						ATACTCCCCTCCATGTGGCAT	0.493									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.000602	0	4	66										T	90266558	C	T	90266558	2	4	121	1	0	0	0	0	0	0	0	1	4235	842	30	1		1	DAPK1	9	90266558	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3748416	90266558	50946873	263	36298										
FAM75C1	441452	broad.mit.edu	37	chr9	90536698	90536698	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acgtgaaaaccagcaatctaGcagccccgaaaagtaggaaa	9	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:90536698G>A	uc010mqi.2	+	4	1905	c.1876G>A	c.(1876-1878)GCA>ACA	p.A626T	FAM75C1_uc004apq.3_Missense_Mutation_p.A609T	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CAGCAATCTAGCAGCCCCGAA	0.537													0	0	0	0.002836	0	29	62										A	90536698	G	A	90536698	3	1	121	1	0	0	0	0	1	0	0	0	5623	971	34	2	1890	2	FAM75C1	9	90536698	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	270140	90536698	50676733	264	36299										
NCBP1	4686	broad.mit.edu	37	chr9	100433475	100433475	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagcagttctgtgccctgcaGgcctaagggtcattttttcc	10	12	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:100433475G>A	uc004axq.2	+	23	2826	c.2367G>A	c.(2365-2367)CAG>CAA	p.Q789Q		NM_002486	NP_002477	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	789					gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			central_nervous_system(1)	1		Acute lymphoblastic leukemia(62;0.158)				GTGCCCTGCAGGCCTAAGGGT	0.393													0	0	0	0.010729	0	10	26										A	100433475	G	A	100433475	2	1	121	1	0	0	0	0	0	0	0	1	10211	991	35	2		2	NCBP1	9	100433475	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	9896777	100433475	40779956	265	36300										
FKBP15	23307	broad.mit.edu	37	chr9	115931551	115931551	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgagggctgctcctgcaacTgtggaacctgcctctgtgct	12	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:115931551T>A	uc004bgs.2	-	26	3556	c.3438A>T	c.(3436-3438)ACA>ACT	p.T1146T	FKBP15_uc004bgr.2_Silent_p.T583T|FKBP15_uc011lxc.1_Silent_p.T727T|FKBP15_uc011lxd.1_Silent_p.T1078T	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	1146					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						CTCCTGCAACTGTGGAACCTG	0.562													0	0	0	0.003163	0	11	32										A	115931551	T	A	115931551	2	1	121	1	0	0	0	0	0	0	0	1	5905	1567	55	5		5	FKBP15	9	115931551	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	15498076	115931551	25281880	266	36301										
RPL35	11224	broad.mit.edu	37	chr9	127623766	127623766	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agctgggacagctccaccttCaggtcgtccagctgtttcag	11	13	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:127623766C>T	uc004boy.1	-	2	121	c.72G>A	c.(70-72)CTG>CTA	p.L24L	ARPC5L_uc004boz.1_5'Flank	NM_007209	NP_009140	P42766	RL35_HUMAN	ribosomal protein L35	24					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome			ovary(1)	1				GBM - Glioblastoma multiforme(294;0.182)		GCTCCACCTTCAGGTCGTCCA	0.612													0	0	0	0.00361	0	44	10										T	127623766	C	T	127623766	2	4	121	1	0	0	0	0	0	0	0	1	13584	813	29	1		1	RPL35	9	127623766	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	11692215	127623766	13589665	267	36302										
BARHL1	56751	broad.mit.edu	37	chr9	135458598	135458598	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaggccgcggaggactttagAgacaagctggacaaaagtgg	15	7	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:135458598A>G	uc004cbp.1	+	1	606	c.414A>G	c.(412-414)AGA>AGG	p.R138R		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	138						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		AGGACTTTAGAGACAAGCTGG	0.582													0	0	0	0.004007	0	15	2										G	135458598	A	G	135458598	2	3	121	1	0	0	0	0	0	0	0	1	1313	301	11	5		5	BARHL1	9	135458598	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	7834832	135458598	5754833	268	36303										
COL5A1	1289	broad.mit.edu	37	chr9	137687131	137687131	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgaggggtgaaagaggcccCcggggcatcactgggaagcc	17	12	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:137687131C>G	uc004cfe.2	+	34	3151	c.2769C>G	c.(2767-2769)CCC>CCG	p.P923P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	923	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AAAGAGGCCCCCGGGGCATCA	0.632													0	0	0	0.003163	0	12	63										G	137687131	C	G	137687131	2	3	121	1	0	0	0	0	0	0	0	1	3696	610	22	4		4	COL5A1	9	137687131	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2228533	137687131	3526300	269	36304										
KCNT1	57582	broad.mit.edu	37	chr9	138675901	138675901	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaatggctccaacctggcctTcatgttccgcctgccgttcg	10	15	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr9:138675901T>A	uc011mdq.1	+	25	2947	c.2873T>A	c.(2872-2874)TTC>TAC	p.F958Y	KCNT1_uc011mdr.1_Missense_Mutation_p.F785Y|KCNT1_uc010nbf.2_Missense_Mutation_p.F913Y|KCNT1_uc004cgo.1_Missense_Mutation_p.F707Y	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	958						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AACCTGGCCTTCATGTTCCGC	0.662													0	0	0	0.00361	0	67	23										A	138675901	T	A	138675901	3	1	121	1	0	0	0	0	1	0	0	0	8091	1783	62	5	2971	5	KCNT1	9	138675901	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	988770	138675901	2537530	270	36305										
FBXO18	84893	broad.mit.edu	37	chr10	5951204	5951204	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gggaccaccccctcctccccGaggctgaggcgtgtgtgcgg	15	16	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:5951204G>A	uc001iis.2	+	5	1062	c.967G>A	c.(967-969)GAG>AAG	p.E323K	FBXO18_uc001iir.2_Missense_Mutation_p.E249K|FBXO18_uc009xig.2_Missense_Mutation_p.E249K|FBXO18_uc001iit.2_Missense_Mutation_p.E374K	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	323					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCTCCTCCCCGAGGCTGAGGC	0.617													0	0	0	0.00361	0	50	22										A	5951204	G	A	5951204	3	1	121	1	0	0	0	0	1	0	0	0	5731	1059	37	1	1147	1	FBXO18	10	5951204	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		5951204	129583543	271	36306										
BEND7	222389	broad.mit.edu	37	chr10	13481367	13481367	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtaaggttgttcaggagcacGagatgctgctcctcccaggg	14	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:13481367G>A	uc001imm.2	-	9	1509	c.1212C>T	c.(1210-1212)CTC>CTT	p.L404L	BEND7_uc001iml.2_RNA	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	455							protein binding			ovary(1)|breast(1)	2						TCAGGAGCACGAGATGCTGCT	0.493													0	0	0	0.00245	0	13	41										A	13481367	G	A	13481367	2	1	121	1	0	0	0	0	0	0	0	1	1403	1045	37	1		1	BEND7	10	13481367	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	7530163	13481367	122053380	272	36307										
FAM188A	80013	broad.mit.edu	37	chr10	15875631	15875631	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aacaaggaatatacttactcAttcctgagcactctctatca	4	11	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:15875631A>G	uc001iod.1	-	8	949	c.728T>C	c.(727-729)ATG>ACG	p.M243T	FAM188A_uc001ioe.1_Missense_Mutation_p.M70T|FAM188A_uc001iof.1_Missense_Mutation_p.M243T	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	243					apoptosis	nucleus	calcium ion binding			ovary(1)	1						ATACTTACTCATTCCTGAGCA	0.249													0	0	0	0.00361	0	49	25										G	15875631	A	G	15875631	3	3	121	1	0	0	0	0	1	0	0	0	5514	217	8	5	641	5	FAM188A	10	15875631	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2394264	15875631	119659116	273	36308										
ABI1	10006	broad.mit.edu	37	chr10	27052865	27052865	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtggtgctggtggagctccaGaaggaggagggacagaaatg	19	5	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:27052865G>T	uc001isx.2	-	8	1012	c.845C>A	c.(844-846)TCT>TAT	p.S282Y	ABI1_uc001ite.2_Intron|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Intron|ABI1_uc001ita.2_Intron|ABI1_uc001isz.2_Intron|ABI1_uc001itb.2_Missense_Mutation_p.S299Y|ABI1_uc001itc.2_Intron|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Intron|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Intron	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	282	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						TGGAGCTCCAGAAGGAGGAGG	0.413													1	0	2.98393e-07	0.00278	3.11978e-07	21	41										T	27052865	G	T	27052865	3	4	121	1	0	0	0	0	1	0	0	0	88	942	33	3	701	3	ABI1	10	27052865	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	11177234	27052865	108481882	274	36309										
ARHGAP12	94134	broad.mit.edu	37	chr10	32197606	32197606	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggctggcacataaaacgcttTggagttttcatctggcttga	11	8	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:32197606T>C	uc001ivz.1	-	3	448	c.178A>G	c.(178-180)AAA>GAA	p.K60E	ARHGAP12_uc001ivy.1_Missense_Mutation_p.K58E|ARHGAP12_uc009xls.2_Missense_Mutation_p.K58E|ARHGAP12_uc001iwb.1_Missense_Mutation_p.K58E|ARHGAP12_uc001iwc.1_Missense_Mutation_p.K58E|ARHGAP12_uc009xlq.1_Missense_Mutation_p.K58E|ARHGAP12_uc001iwd.1_Missense_Mutation_p.K58E|ARHGAP12_uc009xlr.1_Missense_Mutation_p.K58E	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	60	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TAAAACGCTTTGGAGTTTTCA	0.468													0	0	0	0.008291	0	10	6										C	32197606	T	C	32197606	3	2	121	1	0	0	0	0	1	0	0	0	865	1821	63	5	2434	5	ARHGAP12	10	32197606	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	5144741	32197606	103337141	275	36310										
ITGB1	3688	broad.mit.edu	37	chr10	33211203	33211203	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acattgtatgcatcaatgatCaactgaattacattgctaga	6	7	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:33211203C>T	uc001iws.3	-	9	1246	c.1110G>A	c.(1108-1110)TTG>TTA	p.L370L	ITGB1_uc001iwp.3_Silent_p.L370L|ITGB1_uc001iwq.3_Silent_p.L370L|ITGB1_uc001iwr.3_Silent_p.L370L|ITGB1_uc001iwt.3_Silent_p.L370L|ITGB1_uc001iwu.1_Silent_p.L370L	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	370	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				CATCAATGATCAACTGAATTA	0.323													0	0	0	0.00623	0	28	84										T	33211203	C	T	33211203	2	4	121	1	0	0	0	0	0	0	0	1	7890	825	29	1		1	ITGB1	10	33211203	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1013597	33211203	102323544	276	36311										
SLC18A3	6572	broad.mit.edu	37	chr10	50820268	50820268	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagccaccgcaaggtctgtaCgatgcggtgcgcctgcgtga	15	12	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:50820268C>T	uc001jhw.2	+	1	1922	c.1482C>T	c.(1480-1482)TAC>TAT	p.Y494Y	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	494	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						AAGGTCTGTACGATGCGGTGC	0.647													0	0	0	0.010504	0	17	25										T	50820268	C	T	50820268	2	4	121	1	0	0	0	0	0	0	0	1	14427	547	19	2		2	SLC18A3	10	50820268	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17609065	50820268	84714479	277	36312										
PCDH15	65217	broad.mit.edu	37	chr10	55782693	55782693	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccagctggcaaattctcttCaacaaggacagtgtatgttg	9	10	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:55782693C>T	uc001jju.1	-	19	2880	c.2485G>A	c.(2485-2487)GAA>AAA	p.E829K	PCDH15_uc010qhq.1_Missense_Mutation_p.E834K|PCDH15_uc010qhr.1_Missense_Mutation_p.E829K|PCDH15_uc010qhs.1_Missense_Mutation_p.E841K|PCDH15_uc010qht.1_Missense_Mutation_p.E836K|PCDH15_uc010qhu.1_Missense_Mutation_p.E829K|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.E829K|PCDH15_uc010qhw.1_Missense_Mutation_p.E792K|PCDH15_uc010qhx.1_Missense_Mutation_p.E758K|PCDH15_uc010qhy.1_Missense_Mutation_p.E834K|PCDH15_uc010qhz.1_Missense_Mutation_p.E829K|PCDH15_uc010qia.1_Missense_Mutation_p.E807K|PCDH15_uc010qib.1_Missense_Mutation_p.E807K|PCDH15_uc001jjw.2_Missense_Mutation_p.E829K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	829	Extracellular (Potential).|Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AAATTCTCTTCAACAAGGACA	0.393										HNSCC(58;0.16)			0	0	0	0.00361	0	99	5										T	55782693	C	T	55782693	3	4	121	1	0	0	0	0	1	0	0	0	11511	835	29	1	5061	1	PCDH15	10	55782693	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	4962425	55782693	79752054	278	36313										
DNA2	1763	broad.mit.edu	37	chr10	70206090	70206090	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttggcaggcacagggtacatCtgaccagtcttgaggtagag	14	8	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:70206090C>T	uc001jof.2	-	7	1278	c.1278G>A	c.(1276-1278)CAG>CAA	p.Q426Q	DNA2_uc001jog.1_Silent_p.Q340Q|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	340					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						CAGGGTACATCTGACCAGTCT	0.453													0	0	0	0.001168	0	5	4										T	70206090	C	T	70206090	2	4	121	1	0	0	0	0	0	0	0	1	4596	912	32	1		1	DNA2	10	70206090	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	14423397	70206090	65328657	279	36314										
TSPAN14	81619	broad.mit.edu	37	chr10	82269119	82269119	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtggccgtgctggccttcctGttccaggactgggtgaggga	17	10	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:82269119G>A	uc001kcj.3	+	5	449	c.342G>A	c.(340-342)CTG>CTA	p.L114L	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.L97L	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	114						integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			TGGCCTTCCTGTTCCAGGACT	0.592													0	0	0	0.00278	0	20	16										A	82269119	G	A	82269119	2	1	121	1	0	0	0	0	0	0	0	1	16635	1364	48	2		2	TSPAN14	10	82269119	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	12063029	82269119	53265628	280	36315										
PDCD4	27250	broad.mit.edu	37	chr10	112650398	112650398	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgtggggctctggaggtggGcagcaatctgtcaatcacct	15	9	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:112650398G>C	uc001kzh.2	+	8	1203	c.960G>C	c.(958-960)GGG>GGC	p.G320G	PDCD4_uc001kzg.2_Silent_p.G309G|PDCD4_uc010qre.1_Silent_p.G306G	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	320					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CTGGAGGTGGGCAGCAATCTG	0.398													0	0	0	0.00278	0	15	25										C	112650398	G	C	112650398	2	2	121	1	0	0	0	0	0	0	0	1	11621	1190	42	4		4	PDCD4	10	112650398	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	30381279	112650398	22884349	281	36316										
PNLIP	5406	broad.mit.edu	37	chr10	118327270	118327270	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caacttctgtagtccagaaaCcgtcagggaggaagttctgc	11	10	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:118327270C>T	uc001lcm.2	+	13	1401	c.1358C>T	c.(1357-1359)ACC>ATC	p.T453I		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	453	PLAT.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AGTCCAGAAACCGTCAGGGAG	0.433													0	0	0	0.004878	0	27	3										T	118327270	C	T	118327270	3	4	121	1	0	0	0	0	1	0	0	0	12149	507	18	2	1404	2	PNLIP	10	118327270	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5676872	118327270	17207477	282	36317										
PNLIPRP1	5407	broad.mit.edu	37	chr10	118352009	118352009	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccggttcatcatccatggcTtcatagacaaaggagatgag	10	10	3	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:118352009T>A	uc001lco.1	+	4	304	c.286T>A	c.(286-288)TTC>ATC	p.F96I	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.F96I|PNLIPRP1_uc001lcn.2_Missense_Mutation_p.F96I|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	96					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		CATCCATGGCTTCATAGACAA	0.488													0	0	0	0.00361	0	49	3										A	118352009	T	A	118352009	3	1	121	1	0	0	0	0	1	0	0	0	12150	1609	56	5	296	5	PNLIPRP1	10	118352009	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	24739	118352009	17182738	283	36318										
EIF3A	8661	broad.mit.edu	37	chr10	120802195	120802195	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctggtctaagagagggctctCtatcttcatcatcccccaga	8	13	5	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:120802195C>G	uc001ldu.2	-	19	2983	c.2837G>C	c.(2836-2838)AGA>ACA	p.R946T	EIF3A_uc010qsu.1_Missense_Mutation_p.R912T|EIF3A_uc009xzg.1_5'UTR	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	946	3.|Asp-rich.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AGAGGGCTCTCTATCTTCATC	0.567													0	0	0	0.00361	0	84	2										G	120802195	C	G	120802195	3	3	121	1	0	0	0	0	1	0	0	0	5012	913	32	1	1327	1	EIF3A	10	120802195	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2450186	120802195	14732552	284	36319										
DMBT1	1755	broad.mit.edu	37	chr10	124357509	124357509	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gacacattgccgaccatcacCttgcctgcatcgacagtagg	9	14	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr10:124357509C>G	uc001lgk.1	+	25	3043	c.2937C>G	c.(2935-2937)ACC>ACG	p.T979T	DMBT1_uc001lgl.1_Silent_p.T969T|DMBT1_uc001lgm.1_Silent_p.T480T|DMBT1_uc009xzz.1_Silent_p.T979T|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_5'UTR	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	979					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CGACCATCACCTTGCCTGCAT	0.453													0	0	0	0.00361	0	122	5										G	124357509	C	G	124357509	2	3	121	1	0	0	0	0	0	0	0	1	4577	668	24	4		4	DMBT1	10	124357509	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3555314	124357509	11177238	285	36320										
OR51G2	81282	broad.mit.edu	37	chr11	4936589	4936589	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgaaaaagagctgagcaaagCaggcatcatggctaatttct	10	7	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:4936589C>T	uc001lzr.1	-	1	305	c.305G>A	c.(304-306)TGC>TAC	p.C102Y		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	102	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGAGCAAAGCAGGCATCATG	0.522													0	0	0	0.009096	0	4	11										T	4936589	C	T	4936589	3	4	121	1	0	0	0	0	1	0	0	0	11099	710	25	2	643	2	OR51G2	11	4936589	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		4936589	130069927	286	36321										
OR52E6	390078	broad.mit.edu	37	chr11	5863035	5863035	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agatacacagagaaaaaaggGaatccaatccagatgtgcac	9	8	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:5863035G>C	uc010qzq.1	-	1	93	c.93C>G	c.(91-93)TTC>TTG	p.F31L	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAAAAAAGGGAATCCAATCC	0.458													0	0	0	0.012319	0	13	35										C	5863035	G	C	5863035	3	2	121	1	0	0	0	0	1	0	0	0	11117	1165	41	1	850	1	OR52E6	11	5863035	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	926446	5863035	129143481	287	36322										
IPO7	10527	broad.mit.edu	37	chr11	9450663	9450663	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttagagctaacaagaagatGtctgattgatgatagagaaa	10	4	1	7			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:9450663G>A	uc001mho.2	+	14	1653	c.1511G>A	c.(1510-1512)TGT>TAT	p.C504Y		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	504					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		ACAAGAAGATGTCTGATTGAT	0.378													0	0	0	0.005443	0	18	4										A	9450663	G	A	9450663	3	1	121	1	0	0	0	0	1	0	0	0	7797	1377	48	2	1565	2	IPO7	11	9450663	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3587628	9450663	125555853	288	36323										
DKK3	27122	broad.mit.edu	37	chr11	11987391	11987391	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggaggccactggcacaaggGcatcggtccaaggctccatc	13	13	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:11987391G>T	uc001mju.2	-	6	852	c.795C>A	c.(793-795)TGC>TGA	p.C265*	DKK3_uc010rcf.1_Nonsense_Mutation_p.C237*|DKK3_uc001mjv.2_Nonsense_Mutation_p.C265*|DKK3_uc001mjw.2_Nonsense_Mutation_p.C265*|DKK3_uc010rcg.1_Nonsense_Mutation_p.C265*	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	265	DKK-type Cys-2.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		TGGCACAAGGGCATCGGTCCA	0.672													1	0	1.75199e-13	0.007291	1.91912e-13	21	1										T	11987391	G	T	11987391	4	4	121	1	0	0	0	0	0	1	0	0	4546	1195	42	4	265	4	DKK3	11	11987391	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2536728	11987391	123019125	289	36324										
DKK3	27122	broad.mit.edu	37	chr11	12020244	12020244	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggggaaatgacaacttacgTggctccttctgccttcttcg	10	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:12020244T>A	uc001mju.2	-	3	491	c.434A>T	c.(433-435)CAC>CTC	p.H145L	DKK3_uc010rcf.1_Intron|DKK3_uc001mjv.2_Missense_Mutation_p.H145L|DKK3_uc001mjw.2_Missense_Mutation_p.H145L|DKK3_uc010rcg.1_Missense_Mutation_p.H145L	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	145					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		ACAACTTACGTGGCTCCTTCT	0.473													0	0	0	0.003755	0	32	1										A	12020244	T	A	12020244	3	1	121	1	0	0	0	0	1	0	0	0	4546	1710	59	5	638	5	DKK3	11	12020244	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	32853	12020244	122986272	290	36325										
MICAL2	9645	broad.mit.edu	37	chr11	12247859	12247859	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagcctgacaagctcagcatGgtcatgtacctctccaagtt	9	12	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:12247859G>A	uc001mjz.2	+	14	2118	c.1830G>A	c.(1828-1830)ATG>ATA	p.M610I	MICAL2_uc010rch.1_Missense_Mutation_p.M610I|MICAL2_uc001mka.2_Missense_Mutation_p.M610I|MICAL2_uc010rci.1_Missense_Mutation_p.M610I|MICAL2_uc001mkb.2_Missense_Mutation_p.M610I|MICAL2_uc001mkc.2_Missense_Mutation_p.M610I|MICAL2_uc001mkd.2_Missense_Mutation_p.M439I|MICAL2_uc010rcj.1_Missense_Mutation_p.M12I	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	610	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		AGCTCAGCATGGTCATGTACC	0.582													0	0	0	0.00361	0	47	7										A	12247859	G	A	12247859	3	1	121	1	0	0	0	0	1	0	0	0	9570	1348	47	2	1876	2	MICAL2	11	12247859	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	227615	12247859	122758657	291	36326										
PDE3B	5140	broad.mit.edu	37	chr11	14856593	14856593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atctgacaacacggccagttCctggcttacagcagatccac	8	14	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:14856593C>T	uc001mln.2	+	11	2625	c.2272C>T	c.(2272-2274)CCT>TCT	p.P758S	PDE3B_uc010rcr.1_Missense_Mutation_p.P707S	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	758	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						ACGGCCAGTTCCTGGCTTACA	0.383													0	0	0	0.00361	0	41	40										T	14856593	C	T	14856593	3	4	121	1	0	0	0	0	1	0	0	0	11638	855	30	1	2314	1	PDE3B	11	14856593	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2608734	14856593	120149923	292	36327										
LDHC	3948	broad.mit.edu	37	chr11	18434294	18434294	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtcaaggagcagctaattgaGaagctaattgaggatgatga	13	4	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:18434294G>A	uc001mon.3	+	2	142	c.30G>A	c.(28-30)GAG>GAA	p.E10E	LDHC_uc001mom.3_Silent_p.E10E|LDHC_uc009yhp.2_Silent_p.E10E|LDHC_uc001moo.3_5'UTR|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_5'UTR	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	10					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	AGCTAATTGAGAAGCTAATTG	0.393													0	0	0	0.00245	0	12	52										A	18434294	G	A	18434294	2	1	121	1	0	0	0	0	0	0	0	1	8702	933	33	1		1	LDHC	11	18434294	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3577701	18434294	116572222	293	36328										
NELL1	4745	broad.mit.edu	37	chr11	20940866	20940866	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atttacaagagcttttggccAagatgactgcaaaagtaggt	10	6	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:20940866A>T	uc001mqe.2	+	7	898	c.745A>T	c.(745-747)AAG>TAG	p.K249*	NELL1_uc001mqf.2_Nonsense_Mutation_p.K249*|NELL1_uc009yid.2_Nonsense_Mutation_p.K277*|NELL1_uc010rdo.1_Nonsense_Mutation_p.K192*|NELL1_uc010rdp.1_Nonsense_Mutation_p.K9*	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	249					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GCTTTTGGCCAAGATGACTGC	0.318													0	0	0	0.003271	0	26	40										T	20940866	A	T	20940866	4	4	121	1	0	0	0	0	0	1	0	0	10333	131	5	5	771	5	NELL1	11	20940866	Nonsense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2506572	20940866	114065650	294	36329										
CCDC73	493860	broad.mit.edu	37	chr11	32781668	32781668	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcttacccttctcatacgcAattcttctaatgcctccagt	4	14	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:32781668A>T	uc001mtv.2	-	2	166	c.122T>A	c.(121-123)TTG>TAG	p.L41*	CCDC73_uc001mtw.1_Nonsense_Mutation_p.L41*|CCDC73_uc009yjt.2_Nonsense_Mutation_p.L41*	NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	41										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TCTCATACGCAATTCTTCTAA	0.289													0	0	0	0.001168	0	5	111										T	32781668	A	T	32781668	4	4	121	1	0	0	0	0	0	1	0	0	2846	131	5	5	3185	5	CCDC73	11	32781668	Nonsense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	11840802	32781668	102224848	295	36330										
HIPK3	10114	broad.mit.edu	37	chr11	33370305	33370305	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgagtcctgcagtgagtgtCatcactatcagcagtgacac	10	12	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:33370305C>T	uc001mul.1	+	13	2877	c.2607C>T	c.(2605-2607)GTC>GTT	p.V869V	HIPK3_uc001mum.1_Silent_p.V848V|HIPK3_uc009yjv.1_Silent_p.V848V	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	869	SUMO interaction motifs (SIM); required for nuclear localization and kinase activity (By similarity).|Interaction with FAS (By similarity).|Required for localization to nuclear speckles (By similarity).|Interaction with AR (By similarity).				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						CAGTGAGTGTCATCACTATCA	0.473													0	0	0	0.00361	0	56	84										T	33370305	C	T	33370305	2	4	121	1	0	0	0	0	0	0	0	1	7118	813	29	1		1	HIPK3	11	33370305	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	588637	33370305	101636211	296	36331										
ABTB2	25841	broad.mit.edu	37	chr11	34226117	34226117	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgagatgctgcccacgcagGtggccaggagggactgctcc	15	14	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:34226117G>A	uc001mvl.1	-	2	676	c.446C>T	c.(445-447)ACC>ATC	p.T149I		NM_145804	NP_665803	Q8N961	ABTB2_HUMAN	ankyrin repeat and BTB (POZ) domain containing	149							DNA binding			central_nervous_system(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				GCCCACGCAGGTGGCCAGGAG	0.642													0	0	0	0.00361	0	36	33										A	34226117	G	A	34226117	3	1	121	1	0	0	0	0	1	0	0	0	103	1261	44	2	2137	2	ABTB2	11	34226117	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	855812	34226117	100780399	297	36332										
LRRC4C	57689	broad.mit.edu	37	chr11	40136115	40136115	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctttccatgggtgtgtctccCgtaatctcatcatccacatt	6	13	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:40136115C>A	uc001mxa.1	-	2	3692	c.1728G>T	c.(1726-1728)ACG>ACT	p.T576T	LRRC4C_uc001mxc.1_Silent_p.T572T|LRRC4C_uc001mxd.1_Silent_p.T572T|LRRC4C_uc001mxb.1_Silent_p.T572T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	576					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTGTGTCTCCCGTAATCTCAT	0.458													1	0	1.42923e-14	0.00361	1.58117e-14	44	59										A	40136115	C	A	40136115	2	1	121	1	0	0	0	0	0	0	0	1	9008	639	23	4		4	LRRC4C	11	40136115	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5909998	40136115	94870401	298	36333										
EXT2	2132	broad.mit.edu	37	chr11	44255775	44255775	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttcctggtggccaacgtcacGggaaaagcagttatcaaggt	12	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:44255775G>T	uc001mxz.2	+	12	2251	c.1917G>T	c.(1915-1917)ACG>ACT	p.T639T	EXT2_uc010rfo.1_Silent_p.T667T|EXT2_uc001mxy.2_Silent_p.T652T|EXT2_uc009ykt.2_Silent_p.T649T|EXT2_uc001mya.2_Silent_p.T672T	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	639	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						CCAACGTCACGGGAAAAGCAG	0.284			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				1	0	8.24728e-16	0.004656	9.1851e-16	23	16										T	44255775	G	T	44255775	2	4	121	1	0	0	0	0	0	0	0	1	5324	1103	39	4		4	EXT2	11	44255775	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4119660	44255775	90750741	299	36334										
CKAP5	9793	broad.mit.edu	37	chr11	46802036	46802036	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgaaagctttgacattcaacCtagaagaaacatttagaatt	6	6	1	5			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:46802036C>T	uc001ndi.1	-	19	2360	c.2250_splice	c.e19-1	p.G750_splice	CKAP5_uc009ylg.1_Splice_Site_p.G636_splice|CKAP5_uc001ndj.1_Splice_Site_p.G750_splice	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein						cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						GACATTCAACCTAGAAGAAAC	0.338													0	0	0	0.00245	0	11	10										T	46802036	C	T	46802036	5	4	121	1	0	0	0	0	0	0	1	0	3445	695	24	2	3953	2	CKAP5	11	46802036	Splice_Site	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2546261	46802036	88204480	300	36335										
OR4C3	256144	broad.mit.edu	37	chr11	48346740	48346740	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagccccacgctggcttcccCtgtgtattttttcctggcca	8	16	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:48346740C>T	uc010rhv.1	+	1	248	c.248C>T	c.(247-249)CCT>CTT	p.P83L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTGGCTTCCCCTGTGTATTTT	0.458													0	0	0	0.001168	0	3	35										T	48346740	C	T	48346740	3	4	121	1	0	0	0	0	1	0	0	0	11050	681	24	2	250	2	OR4C3	11	48346740	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1544704	48346740	86659776	301	36336										
OR5AS1	219447	broad.mit.edu	37	chr11	55798291	55798291	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctgcaacccactgctctatActacactgatgtctaggaga	7	12	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:55798291A>G	uc010riw.1	+	1	397	c.397A>G	c.(397-399)ACT>GCT	p.T133A		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					ACTGCTCTATACTACACTGAT	0.463													0	0	0	0.009535	0	33	25										G	55798291	A	G	55798291	3	3	121	1	0	0	0	0	1	0	0	0	11146	391	14	5	399	5	OR5AS1	11	55798291	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	7451551	55798291	79208225	302	36337										
OR8H3	390152	broad.mit.edu	37	chr11	55890516	55890516	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atcctatgtgtccattctctCtaccatcctgaaaattaatt	3	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:55890516C>T	uc001nii.1	+	1	668	c.668C>T	c.(667-669)TCT>TTT	p.S223F		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TCCATTCTCTCTACCATCCTG	0.418													0	0	0	0.00361	0	53	57										T	55890516	C	T	55890516	3	4	121	1	0	0	0	0	1	0	0	0	11239	913	32	1	670	1	OR8H3	11	55890516	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	92225	55890516	79116000	303	36338										
OR5R1	219479	broad.mit.edu	37	chr11	56185025	56185025	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgttgcccctgagtagagcgGatccttaggatagcggcaat	13	9	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:56185025G>A	uc010rji.1	-	1	684	c.684C>T	c.(682-684)ATC>ATT	p.I228I		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAGTAGAGCGGATCCTTAGGA	0.443													0	0	0	0.005524	0	29	41										A	56185025	G	A	56185025	2	1	121	1	0	0	0	0	0	0	0	1	11180	1164	41	1		1	OR5R1	11	56185025	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	294509	56185025	78821491	304	36339										
OR5M10	390167	broad.mit.edu	37	chr11	56345172	56345172	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctaagagaatgaattctgtcActatggtgtggtttggggac	13	5	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:56345172A>G	uc001niz.1	-	1	26	c.26T>C	c.(25-27)GTG>GCG	p.V9A		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAATTCTGTCACTATGGTGTG	0.433													0	0	0	0.010771	0	38	59										G	56345172	A	G	56345172	3	3	121	1	0	0	0	0	1	0	0	0	11173	159	6	5	925	5	OR5M10	11	56345172	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	160147	56345172	78661344	305	36340										
VWCE	220001	broad.mit.edu	37	chr11	61026169	61026170	+	Missense_Mutation	DNP	CG	CG	GA													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acatggtggactcttcccccCgagaagcccccactgggggc					rs143205377	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:61026169_61026170CG>GA	uc001nra.2	-	20	3124_3125	c.2845_2846CG>TC	c.(2845-2847)CGG>TCG	p.R949S	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	949						extracellular region	calcium ion binding			ovary(1)	1						CTCTTCCCCCCGAGAAGCCCCC	0.663													0	0	0	0.004672	0	15	27										GA	61026170	CG	GA	61026169	3	3	121	1	0	0	0	0	1	0	0	0	17242	652	23	4	25	4	VWCE	11	61026169	Missense_Mutation	DNP	CG	TCGA-GV-A3QI-01A-11D-A21Z-08	4680997	61026169	73980347	306	36341										
AHNAK	79026	broad.mit.edu	37	chr11	62292550	62292550	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgtcaccttccacttttggCagagacacatccatgtcacc	6	14	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:62292550C>A	uc001ntl.2	-	5	9639	c.9339G>T	c.(9337-9339)CTG>CTT	p.L3113L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3113					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCACTTTTGGCAGAGACACAT	0.473													1	0	2.68928e-46	0.00361	3.18128e-46	96	127										A	62292550	C	A	62292550	2	1	121	1	0	0	0	0	0	0	0	1	414	697	25	4		4	AHNAK	11	62292550	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1266381	62292550	72713966	307	36342										
ATG2A	23130	broad.mit.edu	37	chr11	64679559	64679560	+	Frame_Shift_Del	DEL	GT	GT	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtctgaccccacacccaccaGtgttatccaggttgagaagg							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:64679559_64679560delGT	uc001obx.2	-	8	1199_1200	c.1084_1085delAC	c.(1084-1086)ACTfs	p.T362fs		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	362							protein binding			ovary(1)|central_nervous_system(1)	2						ACACCCACCAGTGTTATCCAGG	0.639																		17	99	---	---								-	64679560	GT	-	64679559	7	5	121	1	0	1	0	1	0	0	0	0	1093	1029	36	0	4867	0	ATG2A	11	64679559	Frame_Shift_Del	DEL	GT	TCGA-GV-A3QI-01A-11D-A21Z-08	2387009	64679559	70326957	308	36343										
CDCA5	113130	broad.mit.edu	37	chr11	64847132	64847132	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctctccttccttggagctgGactcggcctcagggttcggc	13	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:64847132G>A	uc001ocp.2	-	5	536	c.371C>T	c.(370-372)TCC>TTC	p.S124F		NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	124					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						CTTGGAGCTGGACTCGGCCTC	0.607													0	0	0	0.001168	0	5	2										A	64847132	G	A	64847132	3	1	121	1	0	0	0	0	1	0	0	0	3089	1174	41	1	395	1	CDCA5	11	64847132	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	167573	64847132	70159384	309	36344										
PELI3	246330	broad.mit.edu	37	chr11	66236342	66236342	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgaggaaaccgaggctcagaGaggggaagtgactggcccaa	16	8	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:66236342G>C	uc001oic.3	+	3	355	c.191G>C	c.(190-192)AGA>ACA	p.R64T	PELI3_uc001oib.2_Missense_Mutation_p.R64T|PELI3_uc001oid.3_Intron|PELI3_uc001oie.3_Intron	NM_145065	NP_659502	Q8N2H9	PELI3_HUMAN	pellino 3 alpha isoform 1	64						cytosol	protein binding			ovary(1)	1						gaggctcagagaggggaagtg	0													0	0	0	0.00308	0	8	8										C	66236342	G	C	66236342	3	2	121	1	0	0	0	0	1	0	0	0	11723	942	33	1	197	1	PELI3	11	66236342	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1389210	66236342	68770174	310	36345										
RBM14	10432	broad.mit.edu	37	chr11	66392723	66392723	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agccactaccccaatggctgGctcctatggggcccagccgg	12	16	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:66392723G>T	uc001oit.2	+	2	1515	c.1376G>T	c.(1375-1377)GGC>GTC	p.G459V	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	459	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CCAATGGCTGGCTCCTATGGG	0.622													1	0	4.15467e-78	0.00361	4.9588e-78	84	107										T	66392723	G	T	66392723	3	4	121	1	0	0	0	0	1	0	0	0	13115	1203	42	4	1382	4	RBM14	11	66392723	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	156381	66392723	68613793	311	36346										
CTTN	2017	broad.mit.edu	37	chr11	70277332	70277332	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaaacgcaaacgccccctgtGtcgcccgcacctcagccaac	7	19	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:70277332G>C	uc001opv.3	+	15	1418	c.1212G>C	c.(1210-1212)GTG>GTC	p.V404V	CTTN_uc001opu.2_Silent_p.V367V|CTTN_uc001opw.3_Silent_p.V367V|CTTN_uc010rqm.1_Silent_p.V88V|CTTN_uc001opx.2_Silent_p.V88V	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	404						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CGCCCCCTGTGTCGCCCGCAC	0.562													0	0	0	0.00361	0	71	82										C	70277332	G	C	70277332	2	2	121	1	0	0	0	0	0	0	0	1	4044	1364	48	4		4	CTTN	11	70277332	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3884609	70277332	64729184	312	36347										
NADSYN1	55191	broad.mit.edu	37	chr11	71169536	71169536	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttgcactcgtttcaagtccTagcggcccttgtggagtctc	10	13	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:71169536T>C	uc001oqn.2	+	3	335	c.209T>C	c.(208-210)CTA>CCA	p.L70P	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	70	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTTCAAGTCCTAGCGGCCCTT	0.542													0	0	0	0.012213	0	27	67										C	71169536	T	C	71169536	3	2	121	1	0	0	0	0	1	0	0	0	10138	1522	53	5	219	5	NADSYN1	11	71169536	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	892204	71169536	63836980	313	36348										
SLCO2B1	11309	broad.mit.edu	37	chr11	74911311	74911311	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcgtggtggagggcaaccccGtgctggcaggatcctgcgac	17	12	0	0	rs149242910	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:74911311G>A	uc001owb.2	+	11	2029	c.1642G>A	c.(1642-1644)GTG>ATG	p.V548M	SLCO2B1_uc010rrq.1_Missense_Mutation_p.V293M|SLCO2B1_uc010rrr.1_Missense_Mutation_p.V404M|SLCO2B1_uc010rrs.1_Missense_Mutation_p.V432M|SLCO2B1_uc001owc.2_Missense_Mutation_p.V321M|SLCO2B1_uc001owd.2_Missense_Mutation_p.V526M	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	548	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	GGGCAACCCCGTGCTGGCAGG	0.632													0	0	0	0.00361	0	82	110										A	74911311	G	A	74911311	3	1	121	1	0	0	0	0	1	0	0	0	14727	1145	40	2	1684	2	SLCO2B1	11	74911311	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3741775	74911311	60095205	314	36349										
PRKRIR	5612	broad.mit.edu	37	chr11	76062849	76062849	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgtgtcactatttataccatCtaaacataaaacaagtgctt	4	8	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:76062849C>G	uc001oxh.1	-	5	1345	c.1345G>C	c.(1345-1347)GAT>CAT	p.D449H	PRKRIR_uc010rrz.1_Missense_Mutation_p.D274H	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	449					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						TTTATACCATCTAAACATAAA	0.383													0	0	0	0.010818	0	24	24										G	76062849	C	G	76062849	3	3	121	1	0	0	0	0	1	0	0	0	12526	913	32	1	944	1	PRKRIR	11	76062849	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1151538	76062849	58943667	315	36350										
CAPN5	726	broad.mit.edu	37	chr11	76826502	76826502	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctggtaaagggccacgcatAcgccgtcactgatgtgcgca	12	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:76826502A>G	uc001oxx.2	+	6	946	c.761A>G	c.(760-762)TAC>TGC	p.Y254C	CAPN5_uc009yup.2_Missense_Mutation_p.Y294C|CAPN5_uc009yuq.2_Missense_Mutation_p.Y290C|CAPN5_uc001oxy.2_Missense_Mutation_p.Y294C	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	254	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GGCCACGCATACGCCGTCACT	0.642													0	0	0	0.008291	0	8	17										G	76826502	A	G	76826502	3	3	121	1	0	0	0	0	1	0	0	0	2629	391	14	5	779	5	CAPN5	11	76826502	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	763653	76826502	58180014	316	36351										
GRM5	2915	broad.mit.edu	37	chr11	88780576	88780576	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcaaattctggacctgaatGgctacagaactggagccagg	12	9	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:88780576G>T	uc001pcq.2	-	1	665	c.465C>A	c.(463-465)GCC>GCA	p.A155A	GRM5_uc009yvm.2_Silent_p.A155A|GRM5_uc009yvn.1_Silent_p.A155A	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	155	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GGACCTGAATGGCTACAGAAC	0.493													1	0	7.11191e-15	0.002836	7.88108e-15	27	21										T	88780576	G	T	88780576	2	4	121	1	0	0	0	0	0	0	0	1	6800	1335	47	4		4	GRM5	11	88780576	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	11954074	88780576	46225940	317	36352										
FAT3	120114	broad.mit.edu	37	chr11	92532922	92532922	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agttgttagccctttggattAtgaagttacatctgcttaca	8	7	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:92532922A>G	uc001pdj.3	+	9	6760	c.6743A>G	c.(6742-6744)TAT>TGT	p.Y2248C		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2248	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTTTGGATTATGAAGTTACA	0.423										TCGA Ovarian(4;0.039)			0	0	0	0.004482	0	9	4										G	92532922	A	G	92532922	3	3	121	1	0	0	0	0	1	0	0	0	5691	449	16	5	6777	5	FAT3	11	92532922	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	3752346	92532922	42473594	318	36353										
AMOTL1	154810	broad.mit.edu	37	chr11	94597966	94597966	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agctcgctggaggcccacatCtggcaagaggaggaggaggt	17	9	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:94597966C>T	uc001pfb.2	+	10	2372	c.2202C>T	c.(2200-2202)ATC>ATT	p.I734I	AMOTL1_uc001pfc.2_Silent_p.I684I	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	734	Potential.					cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				AGGCCCACATCTGGCAAGAGG	0.557													0	0	0	0.006999	0	30	134										T	94597966	C	T	94597966	2	4	121	1	0	0	0	0	0	0	0	1	583	903	32	1		1	AMOTL1	11	94597966	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2065044	94597966	40408550	319	36354										
ATM	472	broad.mit.edu	37	chr11	108175524	108175524	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagggatttttcaccagctgTcttcgacacttctcgcaaac	7	13	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:108175524T>C	uc001pkb.1	+	37	6004	c.5619T>C	c.(5617-5619)TGT>TGC	p.C1873C	ATM_uc009yxr.1_Silent_p.C1873C|ATM_uc001pke.1_Silent_p.C525C|ATM_uc001pkg.1_Silent_p.C230C|ATM_uc009yxt.1_Missense_Mutation_p.S17P	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1873					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TCACCAGCTGTCTTCGACACT	0.368			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.010729	0	11	23										C	108175524	T	C	108175524	2	2	121	1	0	0	0	0	0	0	0	1	1109	1673	58	5		5	ATM	11	108175524	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	13577558	108175524	26830992	320	36355										
C11orf57	55216	broad.mit.edu	37	chr11	111951225	111951225	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gacactggaagatgattttcTtaaggctaaatcctggaata	9	6	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:111951225T>C	uc001pmr.3	+	4	944	c.263T>C	c.(262-264)CTT>CCT	p.L88P	C11orf57_uc001pmu.2_Missense_Mutation_p.L88P|C11orf57_uc001pmw.3_Missense_Mutation_p.L88P|C11orf57_uc001pmt.3_Missense_Mutation_p.L88P|C11orf57_uc001pmv.3_Missense_Mutation_p.L88P|C11orf57_uc001pms.3_Missense_Mutation_p.L59P	NM_001082970	NP_001076439	Q6ZUT1	CK057_HUMAN	hypothetical protein LOC55216 isoform b	88										breast(2)|ovary(1)	3		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		GATGATTTTCTTAAGGCTAAA	0.373													0	0	0	0.008291	0	9	31										C	111951225	T	C	111951225	3	2	121	1	0	0	0	0	1	0	0	0	1650	1609	56	5	273	5	C11orf57	11	111951225	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	3775701	111951225	23055291	321	36356										
USP28	57646	broad.mit.edu	37	chr11	113694349	113694350	+	Frame_Shift_Del	DEL	TT	TT	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttccaatttttgctgcagaaTttttatttcctccttcaact							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:113694349_113694350delTT	uc001poh.2	-	12	1293_1294	c.1260_1261delAA	c.(1258-1263)AAAATTfs	p.K420fs	USP28_uc001pog.2_Frame_Shift_Del_p.K128fs|USP28_uc010rwy.1_Frame_Shift_Del_p.K295fs|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Frame_Shift_Del_p.K420fs	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	420_421					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TGCTGCAGAATTTTTATTTCCT	0.302																		25	29	---	---								-	113694350	TT	-	113694349	7	5	121	1	0	1	0	1	0	0	0	0	17055	1493	52	0	2028	0	USP28	11	113694349	Frame_Shift_Del	DEL	TT	TCGA-GV-A3QI-01A-11D-A21Z-08	1743124	113694349	21312167	322	36357										
BUD13	84811	broad.mit.edu	37	chr11	116643573	116643573	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgccaggcttcggccgcttTttgcgacgcttgcgaccgga	13	15	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:116643573T>A	uc001ppn.2	-	1	142	c.108A>T	c.(106-108)AAA>AAT	p.K36N	BUD13_uc001ppo.2_Missense_Mutation_p.K36N|BUD13_uc009yzc.2_Missense_Mutation_p.K36N	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	36										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TCGGCCGCTTTTTGCGACGCT	0.692													0	0	0	0.004482	0	6	3										A	116643573	T	A	116643573	3	1	121	1	0	0	0	0	1	0	0	0	1573	1838	64	5	1791	5	BUD13	11	116643573	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2949224	116643573	18362943	323	36358										
OR8B8	26493	broad.mit.edu	37	chr11	124310918	124310918	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaagagggggatctggactcCcggttggtcagttaagcctg	16	8	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:124310918C>A	uc010sal.1	-	1	64	c.64G>T	c.(64-66)GGA>TGA	p.G22*		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ATCTGGACTCCCGGTTGGTCA	0.502													1	0	6.55177e-30	0.007291	7.64182e-30	20	42										A	124310918	C	A	124310918	4	1	121	1	0	0	0	0	0	1	0	0	11230	632	22	4	874	4	OR8B8	11	124310918	Nonsense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7667345	124310918	10695598	324	36359										
OR8A1	390275	broad.mit.edu	37	chr11	124440003	124440003	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgcatccctgcaggcctccCacccagaggagaatggctgc	11	15	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:124440003C>T	uc010san.1	+	1	39	c.39C>T	c.(37-39)CCC>CCT	p.P13P		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GCAGGCCTCCCACCCAGAGGA	0.522													0	0	0	0.00499	0	16	11										T	124440003	C	T	124440003	2	4	121	1	0	0	0	0	0	0	0	1	11225	581	21	2		2	OR8A1	11	124440003	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	129085	124440003	10566513	325	36360										
NFRKB	4798	broad.mit.edu	37	chr11	129758510	129758510	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcggaaaagcttctgggcaaTgtgcagagggtttccaaagc	13	8	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:129758510T>A	uc001qfi.2	-	4	517	c.316A>T	c.(316-318)ATT>TTT	p.I106F	NFRKB_uc001qfg.2_Missense_Mutation_p.I119F|NFRKB_uc001qfh.2_Missense_Mutation_p.I129F|NFRKB_uc010sbw.1_Missense_Mutation_p.I106F	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	106					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TTCTGGGCAATGTGCAGAGGG	0.493													0	0	0	0.00623	0	28	46										A	129758510	T	A	129758510	3	1	121	1	0	0	0	0	1	0	0	0	10384	1464	51	5	3715	5	NFRKB	11	129758510	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	5318507	129758510	5248006	326	36361										
SNX19	399979	broad.mit.edu	37	chr11	130785171	130785171	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtggggcttgggcaccagccCttgaagcaacaaattcacaa	11	11	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr11:130785171C>T	uc001qgk.3	-	1	1212	c.664G>A	c.(664-666)GGG>AGG	p.G222R	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.G222R|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	222	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		GGCACCAGCCCTTGAAGCAAC	0.567													0	0	0	0.007413	0	14	12										T	130785171	C	T	130785171	3	4	121	1	0	0	0	0	1	0	0	0	14890	681	24	2	2358	2	SNX19	11	130785171	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1026661	130785171	4221345	327	36362										
B4GALNT3	283358	broad.mit.edu	37	chr12	662804	662804	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggagtcgtacatcgcagagcAgagacggggtgacaggatgc	17	8	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:662804A>T	uc001qii.1	+	14	1715	c.1715A>T	c.(1714-1716)CAG>CTG	p.Q572L	B4GALNT3_uc001qij.1_Missense_Mutation_p.Q475L|B4GALNT3_uc001qik.1_Missense_Mutation_p.Q121L	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	572	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			ATCGCAGAGCAGAGACGGGGT	0.637													0	0	0	0.012213	0	24	23										T	662804	A	T	662804	3	4	121	1	0	0	0	0	1	0	0	0	1268	188	7	5	1769	5	B4GALNT3	12	662804	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08		662804	133189091	328	36363										
C12orf4	57102	broad.mit.edu	37	chr12	4599748	4599748	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcccatgaagccatttccatCatgaaacctaaaatagaaaa	4	10	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:4599748C>T	uc001qms.2	-	13	1594	c.1506G>A	c.(1504-1506)ATG>ATA	p.M502I	C12orf4_uc001qmt.2_Missense_Mutation_p.M502I	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	502											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		CCATTTCCATCATGAAACCTA	0.388													0	0	0	0.007835	0	31	37										T	4599748	C	T	4599748	3	4	121	1	0	0	0	0	1	0	0	0	1685	826	29	1	160	1	C12orf4	12	4599748	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3936944	4599748	129252147	329	36364										
LAG3	3902	broad.mit.edu	37	chr12	6882428	6882428	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggggctcctgcccagctcccCtgcagccccacaatccccct	8	22	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:6882428C>A	uc001qqt.3	+	2	478	c.129C>A	c.(127-129)CCC>CCA	p.P43P	LAG3_uc001qqs.2_Silent_p.P43P|LAG3_uc001qqu.2_Translation_Start_Site	NM_002286	NP_002277	P18627	LAG3_HUMAN	lymphocyte-activation protein 3 precursor	43	Ig-like V-type.|Extracellular (Potential).					integral to membrane	antigen binding|MHC class II protein binding				0						CCCAGCTCCCCTGCAGCCCCA	0.637													1	0	6.2361e-21	0.007835	7.12392e-21	38	23										A	6882428	C	A	6882428	2	1	121	1	0	0	0	0	0	0	0	1	8600	668	24	4		4	LAG3	12	6882428	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2282680	6882428	126969467	330	36365										
APOBEC1	339	broad.mit.edu	37	chr12	7805283	7805283	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgtaaatttttttataaaatTaacttccacgtgattggtgg	7	5	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:7805283T>C	uc001qtb.2	-	3	227	c.193A>G	c.(193-195)AAT>GAT	p.N65D	APOBEC1_uc001qtc.2_Missense_Mutation_p.N20D|APOBEC1_uc010sgf.1_Missense_Mutation_p.N65D	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	65					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0						tttataaaattaaCTTCCACG	0.473													0	0	0	0.004672	0	2	10										C	7805283	T	C	7805283	3	2	121	1	0	0	0	0	1	0	0	0	787	1754	61	5	529	5	APOBEC1	12	7805283	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	922855	7805283	126046612	331	36366										
SLC2A3	6515	broad.mit.edu	37	chr12	8083210	8083210	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcagcggccatagctcttcaGacccaaggatgaattccaga	10	12	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:8083210G>T	uc001qtr.2	-	5	801	c.539C>A	c.(538-540)TCT>TAT	p.S180Y	SLC2A3_uc001qts.2_Missense_Mutation_p.S180Y	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	180	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TAGCTCTTCAGACCCAAGGAT	0.438													1	0	6.53348e-20	0.003755	7.43811e-20	29	25										T	8083210	G	T	8083210	3	4	121	1	0	0	0	0	1	0	0	0	14545	942	33	3	975	3	SLC2A3	12	8083210	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	277927	8083210	125768685	332	36367										
MFAP5	8076	broad.mit.edu	37	chr12	8800748	8800748	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaggaagtcggaagtaattgGagcgacggagtctcctaggg	17	6	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:8800748G>A	uc001qut.1	-	10	674	c.461C>T	c.(460-462)TCC>TTC	p.S154F	MFAP5_uc001qus.2_Missense_Mutation_p.S144F|MFAP5_uc009zge.1_Missense_Mutation_p.S129F	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor	154						microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)					GAAGTAATTGGAGCGACGGAG	0.453													0	0	0	0.005524	0	26	29										A	8800748	G	A	8800748	3	1	121	1	0	0	0	0	1	0	0	0	9518	1174	41	1	64	1	MFAP5	12	8800748	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	717538	8800748	125051147	333	36368										
STRAP	11171	broad.mit.edu	37	chr12	16036570	16036570	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggggtgcaacactgaataagGatgccaccaaagcagctaca	11	10	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:16036570G>T	uc001rdc.3	+	2	562	c.208G>T	c.(208-210)GAT>TAT	p.D70Y	STRAP_uc010shw.1_Missense_Mutation_p.D83Y|STRAP_uc001rdd.3_Intron	NM_007178	NP_009109	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated	70	WD 2.				mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			skin(1)	1		Hepatocellular(102;0.121)				ACTGAATAAGGATGCCACCAA	0.458													1	0	5.91797e-21	0.012213	6.77211e-21	25	17										T	16036570	G	T	16036570	3	4	121	1	0	0	0	0	1	0	0	0	15325	1174	41	3	214	3	STRAP	12	16036570	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	7235822	16036570	117815325	334	36369										
SLCO1C1	53919	broad.mit.edu	37	chr12	20886039	20886039	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctaactgtctcctaccaaggGtatgttccctcattaaatag	6	11	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:20886039G>C	uc001rej.3	+	11	1737	c.1382_splice	c.e11+1	p.G461_splice	SLCO1C1_uc010sii.1_Splice_Site_p.G461_splice|SLCO1C1_uc010sij.1_Splice_Site_p.G412_splice|SLCO1C1_uc009zip.2_Splice_Site_p.G295_splice|SLCO1C1_uc001rei.2_Splice_Site_p.G461_splice|SLCO1C1_uc010sik.1_Splice_Site_p.G343_splice	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CCTACCAAGGGTATGTTCCCT	0.363													0	0	0	0.00361	0	72	63										C	20886039	G	C	20886039	5	2	121	1	0	0	0	0	0	0	1	0	14725	1275	44	4	1417	4	SLCO1C1	12	20886039	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4849469	20886039	112965856	335	36370										
NELL2	4753	broad.mit.edu	37	chr12	44926364	44926364	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggtcttctccttgtactgacCttcacacgattctccacttg	6	14	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:44926364C>T	uc001rog.2	-	16	2399	c.1804G>A	c.(1804-1806)GAT>AAT	p.D602N	NELL2_uc001rof.3_Missense_Mutation_p.D601N|NELL2_uc001roh.2_Missense_Mutation_p.D602N|NELL2_uc009zkd.2_Intron|NELL2_uc010skz.1_Missense_Mutation_p.D652N|NELL2_uc010sla.1_Missense_Mutation_p.D625N|NELL2_uc001roi.1_Missense_Mutation_p.D602N|NELL2_uc010slb.1_3'UTR	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	602	EGF-like 6; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity	p.D602N(1)		skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTGTACTGACCTTCACACGAT	0.403													0	0	0	0.00361	0	75	67										T	44926364	C	T	44926364	3	4	121	1	0	0	0	0	1	0	0	0	10334	695	24	2	666	2	NELL2	12	44926364	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	24040325	44926364	88925531	336	36371										
HDAC7	51564	broad.mit.edu	37	chr12	48191920	48191920	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atgccggggctgttgggatgGactgttctttctagggccgc	16	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:48191920G>C	uc009zkv.1	-	3	530	c.315C>G	c.(313-315)GTC>GTG	p.V105V	HDAC7_uc010slo.1_Silent_p.V144V|HDAC7_uc001rqj.3_Silent_p.V144V|HDAC7_uc001rqk.3_Silent_p.V127V			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.	105	Interaction with MEF2A (By similarity).|Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		TGTTGGGATGGACTGTTCTTT	0.602													0	0	0	0.00361	0	188	214										C	48191920	G	C	48191920	2	2	121	1	0	0	0	0	0	0	0	1	7012	1161	41	1		1	HDAC7	12	48191920	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3265556	48191920	85659975	337	36372										
COL2A1	1280	broad.mit.edu	37	chr12	48375906	48375906	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttactcgtccaccatcctttCcaggggctccctcagggcct	8	17	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:48375906C>A	uc001rqu.2	-	35	2520	c.2339G>T	c.(2338-2340)GGA>GTA	p.G780V	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.G711V	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	780	Triple-helical region.		G -> R (in ACG2).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	ACCATCCTTTCCAGGGGCTCC	0.617													1	0	1.33835e-49	0.00361	1.58602e-49	79	126										A	48375906	C	A	48375906	3	1	121	1	0	0	0	0	1	0	0	0	3687	855	30	3	2204	3	COL2A1	12	48375906	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	183986	48375906	85475989	338	36373										
ZNF641	121274	broad.mit.edu	37	chr12	48739259	48739259	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccttgatggttaccaggcccTgaaacaaaatgtagcatctt	8	10	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:48739259T>A	uc001rrn.1	-	4	484	c.319_splice	c.e4-1	p.G107_splice	ZNF641_uc001rro.1_Splice_Site_p.G93_splice|ZNF641_uc010sls.1_Intron	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TACCAGGCCCTGAAACAAAAT	0.448													0	0	0	0.00361	0	33	34										A	48739259	T	A	48739259	5	1	121	1	0	0	0	0	0	0	1	0	18054	1594	55	5	1011	5	ZNF641	12	48739259	Splice_Site	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	363353	48739259	85112636	339	36374										
MLL2	8085	broad.mit.edu	37	chr12	49420164	49420164	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcactatgaaagtcagccatCtggtgaggcagcagctgtcc	12	11	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:49420164C>G	uc001rta.3	-	48	15585	c.15585G>C	c.(15583-15585)CAG>CAC	p.Q5195H		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5195	FYR N-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGTCAGCCATCTGGTGAGGCA	0.587			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.00278	0	19	26										G	49420164	C	G	49420164	3	3	121	1	0	0	0	0	1	0	0	0	9621	912	32	1	1056	1	MLL2	12	49420164	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	680905	49420164	84431731	340	36375										
MLL2	8085	broad.mit.edu	37	chr12	49420438	49420438	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggggcaacgcatgcgattgCagctgctggtggcaccagtt	15	10	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:49420438C>T	uc001rta.3	-	48	15311	c.15311G>A	c.(15310-15312)TGC>TAC	p.C5104Y		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5104	RING-type 4; degenerate.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CATGCGATTGCAGCTGCTGGT	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.003271	0	32	32										T	49420438	C	T	49420438	3	4	121	1	0	0	0	0	1	0	0	0	9621	710	25	2	1330	2	MLL2	12	49420438	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	274	49420438	84431457	341	36376										
TUBA1A	7846	broad.mit.edu	37	chr12	49579351	49579351	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcatatgtggccagagggaaGtggatgcggggatagggcac	19	6	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:49579351G>C	uc009zlf.2	-	4	1070	c.798C>G	c.(796-798)CAC>CAG	p.H266Q	TUBA1B_uc001rto.2_Intron|TUBA1A_uc001rtp.2_Missense_Mutation_p.H266Q|TUBA1A_uc001rtq.2_Missense_Mutation_p.H113Q|TUBA1A_uc001rtr.2_Missense_Mutation_p.H113Q|TUBA1A_uc009zlg.2_Missense_Mutation_p.H113Q	NM_006009	NP_006000	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	266					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity				0						CCAGAGGGAAGTGGATGCGGG	0.512													0	0	0	0.003954	0	18	95										C	49579351	G	C	49579351	3	2	121	1	0	0	0	0	1	0	0	0	16740	1020	36	4	561	4	TUBA1A	12	49579351	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	158913	49579351	84272544	342	36377										
DNAJC22	79962	broad.mit.edu	37	chr12	49745187	49745187	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctggcacccagaccacaacCtggaccagacagaggaggca	11	14	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:49745187C>A	uc001rua.2	+	3	1329	c.928C>A	c.(928-930)CTG>ATG	p.L310M	DNAJC22_uc001rub.2_Missense_Mutation_p.L310M	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	310	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						AGACCACAACCTGGACCAGAC	0.542													1	0	1.13719e-10	0.008361	1.22354e-10	25	33										A	49745187	C	A	49745187	3	1	121	1	0	0	0	0	1	0	0	0	4641	680	24	4	934	4	DNAJC22	12	49745187	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	165836	49745187	84106708	343	36378										
NCKAP5L	57701	broad.mit.edu	37	chr12	50189721	50189721	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctggctgggcttcttggatGagttgcctggggtcctgcgg	17	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:50189721G>T	uc009zlk.2	-	8	2124	c.1922C>A	c.(1921-1923)TCA>TAA	p.S641*	NCKAP5L_uc001rvc.3_5'Flank|NCKAP5L_uc001rvb.2_Nonsense_Mutation_p.S234*	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	637										central_nervous_system(1)	1						CTTCTTGGATGAGTTGCCTGG	0.652													1	0	2.0095e-06	0.001984	2.08462e-06	6	2										T	50189721	G	T	50189721	4	4	121	1	0	0	0	0	0	1	0	0	10224	1294	45	3	2106	3	NCKAP5L	12	50189721	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	444534	50189721	83662174	344	36379										
ACVRL1	94	broad.mit.edu	37	chr12	52312784	52312784	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccaggcatcgtggaggactAtagaccacccttctatgatg	10	11	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:52312784A>G	uc001rzj.2	+	9	1545	c.1262A>G	c.(1261-1263)TAT>TGT	p.Y421C	ACVRL1_uc001rzk.2_Missense_Mutation_p.Y421C|ACVRL1_uc010snm.1_Missense_Mutation_p.Y247C	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	421	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GTGGAGGACTATAGACCACCC	0.532									Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.00361	0	52	54										G	52312784	A	G	52312784	3	3	121	1	0	0	0	0	1	0	0	0	225	449	16	5	1292	5	ACVRL1	12	52312784	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2123063	52312784	81539111	345	36380										
KRT85	3891	broad.mit.edu	37	chr12	52758771	52758771	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttgtagccctccagcacctCctgcacatggttgagctctg	9	15	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:52758771C>T	uc001sag.2	-	2	724	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	202	Rod.|Coil 1B.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCCAGCACCTCCTGCACATGG	0.622													0	0	0	0.00361	0	99	157										T	52758771	C	T	52758771	3	4	121	1	0	0	0	0	1	0	0	0	8499	864	30	1	951	1	KRT85	12	52758771	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	445987	52758771	81093124	346	36381										
GDF11	10220	broad.mit.edu	37	chr12	56143318	56143318	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagcttcgagtcctagagaaCacaaaacgttcccggcggaa	11	11	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:56143318C>G	uc001shq.2	+	3	913	c.876C>G	c.(874-876)AAC>AAG	p.N292K	GDF11_uc010spv.1_Missense_Mutation_p.N292K	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	292					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						TCCTAGAGAACACAAAACGTT	0.547													0	0	0	0.008361	0	25	74										G	56143318	C	G	56143318	3	3	121	1	0	0	0	0	1	0	0	0	6312	477	17	4	886	4	GDF11	12	56143318	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3384547	56143318	77708577	347	36382										
PAN2	9924	broad.mit.edu	37	chr12	56713447	56713447	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcatcaatgaaggggataccCtcattgggtccctggccccg	11	13	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:56713447C>A	uc001skx.2	-	22	3433	c.3060G>T	c.(3058-3060)GAG>GAT	p.E1020D	PAN2_uc001skw.2_Missense_Mutation_p.E168D|PAN2_uc001skz.2_Missense_Mutation_p.E1019D|PAN2_uc001sky.2_Missense_Mutation_p.E1016D	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1020	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						AGGGGATACCCTCATTGGGTC	0.498													1	0	9.31168e-06	0.001855	9.58513e-06	13	50										A	56713447	C	A	56713447	3	1	121	1	0	0	0	0	1	0	0	0	11414	680	24	4	568	4	PAN2	12	56713447	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	570129	56713447	77138448	348	36383										
ATP5B	506	broad.mit.edu	37	chr12	57033894	57033894	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccagctcagcaatggcacgcGacagtacagtggtagcatcc	11	13	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:57033894G>A	uc001slr.2	-	8	1262	c.1157C>T	c.(1156-1158)TCG>TTG	p.S386L		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	386					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						AATGGCACGCGACAGTACAGT	0.512													0	0	0	0.004656	0	23	44										A	57033894	G	A	57033894	3	1	121	1	0	0	0	0	1	0	0	0	1148	1059	37	1	444	1	ATP5B	12	57033894	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	320447	57033894	76818001	349	36384										
BEST3	144453	broad.mit.edu	37	chr12	70070964	70070964	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaaaagtatttcttacctggGtgtaaaccagcggaatccca	9	9	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:70070964G>A	uc001svg.2	-	6	937	c.710C>T	c.(709-711)ACC>ATC	p.T237I	BEST3_uc001svd.1_Missense_Mutation_p.T237I|BEST3_uc001sve.1_RNA|BEST3_uc001svf.2_Missense_Mutation_p.T75I|BEST3_uc010stm.1_Missense_Mutation_p.T131I|BEST3_uc001svh.2_Missense_Mutation_p.T75I	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	237						chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TCTTACCTGGGTGTAAACCAG	0.478													0	0	0	0.009096	0	4	16										A	70070964	G	A	70070964	3	1	121	1	0	0	0	0	1	0	0	0	1406	1261	44	2	1316	2	BEST3	12	70070964	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	13037070	70070964	63780931	350	36385										
ALX1	8092	broad.mit.edu	37	chr12	85695132	85695132	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttcactgactctcttcttaCtggggcaaccaatggacatg	8	11	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:85695132C>T	uc001tae.3	+	4	864	c.860C>T	c.(859-861)ACT>ATT	p.T287I		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	287					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TCTCTTCTTACTGGGGCAACC	0.493													0	0	0	0.008871	0	18	51										T	85695132	C	T	85695132	3	4	121	1	0	0	0	0	1	0	0	0	556	565	20	2	874	2	ALX1	12	85695132	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	15624168	85695132	48156763	351	36386										
CEP290	80184	broad.mit.edu	37	chr12	88482860	88482860	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttattaactcttccaggccCtttaattttaattccatctc	2	12	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:88482860C>A	uc001tar.2	-	31	4322	c.3978G>T	c.(3976-3978)AAG>AAT	p.K1326N	CEP290_uc001taq.2_Missense_Mutation_p.K386N	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1326	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						CTTCCAGGCCCTTTAATTTTA	0.259													1	0	3.62473e-10	0.012319	3.88114e-10	17	12										A	88482860	C	A	88482860	3	1	121	1	0	0	0	0	1	0	0	0	3253	680	24	4	3557	4	CEP290	12	88482860	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2787728	88482860	45369035	352	36387										
ATP2B1	490	broad.mit.edu	37	chr12	90004246	90004246	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agatgatcttgcaagtactcGaagttttggccaaatcttgt	9	7	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:90004246G>A	uc001tbh.2	-	13	2468	c.2287C>T	c.(2287-2289)CGA>TGA	p.R763*	ATP2B1_uc001tbg.2_Nonsense_Mutation_p.R763*|ATP2B1_uc001tbf.2_Nonsense_Mutation_p.R433*	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	763	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						GCAAGTACTCGAAGTTTTGGC	0.323													0	0	0	0.00361	0	43	123										A	90004246	G	A	90004246	4	1	121	1	0	0	0	0	0	1	0	0	1139	1066	37	1	1565	1	ATP2B1	12	90004246	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1521386	90004246	43847649	353	36388										
ANKS1B	56899	broad.mit.edu	37	chr12	100048914	100048914	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatgcttcccaaagtcctgaTggcccacacgtattttcatc	6	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:100048914T>A	uc001tge.1	-	9	1620	c.1203A>T	c.(1201-1203)CCA>CCT	p.P401P	ANKS1B_uc001tgf.1_5'UTR|ANKS1B_uc009ztt.1_Silent_p.P367P	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	401						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		AAAGTCCTGATGGCCCACACG	0.393													0	0	0	0.008871	0	16	12										A	100048914	T	A	100048914	2	1	121	1	0	0	0	0	0	0	0	1	689	1451	51	5		5	ANKS1B	12	100048914	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	10044668	100048914	33802981	354	36389										
GLTP	51228	broad.mit.edu	37	chr12	110290444	110290444	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gccgtgtagttgactaggaaGaggcggatcttctccaggca	14	9	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:110290444G>C	uc001tpm.2	-	5	660	c.546C>G	c.(544-546)CTC>CTG	p.L182L	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	182						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		TGACTAGGAAGAGGCGGATCT	0.537											OREG0022112	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	140	213										C	110290444	G	C	110290444	2	2	121	1	0	0	0	0	0	0	0	1	6471	929	33	1		1	GLTP	12	110290444	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	10241530	110290444	23561451	355	36390										
C12orf51	283450	broad.mit.edu	37	chr12	112720937	112720937	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cttgatcctctttcagtgtgTtggagatggtggaaccagtc	12	8	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:112720937T>C	uc009zwc.2	-	2	341	c.323A>G	c.(322-324)AAC>AGC	p.N108S		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TTTCAGTGTGTTGGAGATGGT	0.478													0	0	0	0.00623	0	27	18										C	112720937	T	C	112720937	3	2	121	1	0	0	0	0	1	0	0	0	1696	1725	60	5	11939	5	C12orf51	12	112720937	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2430493	112720937	21130958	356	36391										
RASAL1	8437	broad.mit.edu	37	chr12	113565880	113565880	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaccacaaacccgacagtgtCctcatccagcacgtagaagg	8	14	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:113565880C>A	uc001tum.1	-	4	519	c.226G>T	c.(226-228)GAC>TAC	p.D76Y	RASAL1_uc010syp.1_Missense_Mutation_p.D76Y|RASAL1_uc001tul.2_Missense_Mutation_p.D76Y|RASAL1_uc001tun.1_Missense_Mutation_p.D76Y|RASAL1_uc010syq.1_Missense_Mutation_p.D76Y|RASAL1_uc001tuo.3_Missense_Mutation_p.D76Y|RASAL1_uc010syr.1_Missense_Mutation_p.D76Y	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	76	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						CCGACAGTGTCCTCATCCAGC	0.617													1	0	1.72433e-176	0.00361	2.07293e-176	309	201										A	113565880	C	A	113565880	3	1	121	1	0	0	0	0	1	0	0	0	13063	855	30	3	2264	3	RASAL1	12	113565880	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	844943	113565880	20286015	357	36392										
NOS1	4842	broad.mit.edu	37	chr12	117724011	117724011	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccttgagctggtaagtgctAgtggtgtcgatctctttgtt	12	7	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:117724011A>G	uc001twm.1	-	6	1874	c.1188T>C	c.(1186-1188)ACT>ACC	p.T396T		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	396					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGTAAGTGCTAGTGGTGTCGA	0.562													0	0	0	0.003163	0	14	31										G	117724011	A	G	117724011	2	3	121	1	0	0	0	0	0	0	0	1	10541	407	15	5		5	NOS1	12	117724011	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4158131	117724011	16127884	358	36393										
KSR2	283455	broad.mit.edu	37	chr12	118293355	118293355	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgtcatctccaagaggtccTccaggctcagctggccgggg	13	15	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:118293355T>G	uc001two.2	-	3	318	c.263A>C	c.(262-264)GAG>GCG	p.E88A		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	117					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAAGAGGTCCTCCAGGCTCAG	0.612													0	0	0	0.009535	0	26	20										G	118293355	T	G	118293355	3	3	121	1	0	0	0	0	1	0	0	0	8582	1551	54	5	2574	5	KSR2	12	118293355	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	569344	118293355	15558540	359	36394										
VSIG10	54621	broad.mit.edu	37	chr12	118511557	118511557	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccctacagggctgtcagctCggcagatgtagtagccctca	11	14	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:118511557C>G	uc001tws.2	-	5	1500	c.1166G>C	c.(1165-1167)CGA>CCA	p.R389P		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	389	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane					0						GCTGTCAGCTCGGCAGATGTA	0.577													0	0	0	0.00361	0	48	36										G	118511557	C	G	118511557	3	3	121	1	0	0	0	0	1	0	0	0	17220	884	31	1	476	1	VSIG10	12	118511557	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	218202	118511557	15340338	360	36395										
CIT	11113	broad.mit.edu	37	chr12	120195199	120195199	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgcaatcttgtctccagttcCagcagccgattcttgtcact	7	14	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:120195199C>T	uc001txi.1	-	21	2609	c.2556G>A	c.(2554-2556)CTG>CTA	p.L852L	CIT_uc001txh.1_Silent_p.L386L|CIT_uc001txj.1_Silent_p.L894L	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	852	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TCTCCAGTTCCAGCAGCCGAT	0.557													0	0	0	0.00361	0	189	308										T	120195199	C	T	120195199	2	4	121	1	0	0	0	0	0	0	0	1	3438	581	21	2		2	CIT	12	120195199	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1683642	120195199	13656696	361	36396										
HIP1R	9026	broad.mit.edu	37	chr12	123333067	123333067	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttcaccttctggtcctacgCcattgggctgccgctgccca	9	16	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:123333067C>T	uc001udj.1	+	3	271	c.212C>T	c.(211-213)GCC>GTC	p.A71V	HIP1R_uc001udg.1_Missense_Mutation_p.A59V|HIP1R_uc001udi.1_Missense_Mutation_p.A71V|HIP1R_uc001udh.2_Missense_Mutation_p.A71V	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	71	ENTH.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		TGGTCCTACGCCATTGGGCTG	0.597													0	0	0	0.012319	0	18	46										T	123333067	C	T	123333067	3	4	121	1	0	0	0	0	1	0	0	0	7115	739	26	2	222	2	HIP1R	12	123333067	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3137868	123333067	10518828	362	36397										
SBNO1	55206	broad.mit.edu	37	chr12	123782653	123782653	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgaaccacataatacataaTatgtacggcaacgaagacct	6	10	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:123782653T>A	uc010tap.1	-	30	3911	c.3911A>T	c.(3910-3912)TAT>TTT	p.Y1304F	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Missense_Mutation_p.Y1303F|SBNO1_uc010taq.1_Missense_Mutation_p.Y255F	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1304							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TAATACATAATATGTACGGCA	0.438													0	0	0	0.003755	0	30	56										A	123782653	T	A	123782653	3	1	121	1	0	0	0	0	1	0	0	0	13862	1406	49	5	278	5	SBNO1	12	123782653	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	449586	123782653	10069242	363	36398										
DNAH10	196385	broad.mit.edu	37	chr12	124403343	124403343	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcgtcctgtctgagatggccCtggtgaactccatgtaccag	11	12	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:124403343C>T	uc001uft.3	+	64	11024	c.10999C>T	c.(10999-11001)CTG>TTG	p.L3667L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3667					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGAGATGGCCCTGGTGAACTC	0.577													0	0	0	0.006214	0	7	16										T	124403343	C	T	124403343	2	4	121	1	0	0	0	0	0	0	0	1	4598	680	24	2		2	DNAH10	12	124403343	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	620690	124403343	9448552	364	36399										
SFRS8	6433	broad.mit.edu	37	chr12	132241141	132241141	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gggcaggctcaggcgggaagAaggaggcatcgtccagtaag	18	8	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr12:132241141A>T	uc001uja.1	+	11	1812	c.1672A>T	c.(1672-1674)AAG>TAG	p.K558*	SFRS8_uc010tbn.1_Nonsense_Mutation_p.K558*|SFRS8_uc001ujb.1_Nonsense_Mutation_p.K351*	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	558					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		AGGCGGGAAGAAGGAGGCATC	0.607													0	0	0	0.008291	0	9	14										T	132241141	A	T	132241141	4	4	121	1	0	0	0	0	0	1	0	0	14183	247	9	5	1714	5	SFRS8	12	132241141	Nonsense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	7837798	132241141	1610754	365	36400										
RNF17	56163	broad.mit.edu	37	chr13	25362208	25362208	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggctaaaagctacattgaaGagaaaaaaaataatttgaat	7	3	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr13:25362208G>C	uc001upr.2	+	7	735	c.694G>C	c.(694-696)GAG>CAG	p.E232Q	RNF17_uc010tdd.1_Missense_Mutation_p.E91Q|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.E232Q|RNF17_uc001ups.2_Missense_Mutation_p.E171Q|RNF17_uc001upq.1_Missense_Mutation_p.E232Q	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	232					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTACATTGAAGAGAAAAAAAA	0.303													0	0	0	0.007413	0	19	14										C	25362208	G	C	25362208	3	2	121	1	0	0	0	0	1	0	0	0	13461	943	33	1	720	1	RNF17	13	25362208	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		25362208	89807670	366	36401										
FRY	10129	broad.mit.edu	37	chr13	32869562	32869562	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accgagtcctcactacttttCttccagactccagtgtttct	5	14	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr13:32869562C>G	uc001utx.2	+	61	9503	c.9007C>G	c.(9007-9009)CTT>GTT	p.L3003V	FRY_uc010tdw.1_RNA|FRY_uc001utz.2_Missense_Mutation_p.L534V|FRY_uc010tdx.1_Missense_Mutation_p.L373V	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	3003					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CACTACTTTTCTTCCAGACTC	0.567													0	0	0	0.010818	0	27	25										G	32869562	C	G	32869562	3	3	121	1	0	0	0	0	1	0	0	0	6063	913	32	1	9249	1	FRY	13	32869562	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	7507354	32869562	82300316	367	36402										
FREM2	341640	broad.mit.edu	37	chr13	39265823	39265823	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagacctactaagcactagtGacttgaacagtcctgatgaa	8	10	0	5			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr13:39265823G>C	uc001uwv.2	+	1	4651	c.4342G>C	c.(4342-4344)GAC>CAC	p.D1448H		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1448	Extracellular (Potential).|CSPG 10.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAGCACTAGTGACTTGAACAG	0.488													0	0	0	0.005524	0	31	30										C	39265823	G	C	39265823	3	2	121	1	0	0	0	0	1	0	0	0	6045	1290	45	1	4344	1	FREM2	13	39265823	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6396261	39265823	75904055	368	36403										
ZIC2	7546	broad.mit.edu	37	chr13	100634920	100634920	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgccaggtggccagcccgcGgaccgacccctactcggcgg	14	19	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr13:100634920G>C	uc001von.2	+	1	602	c.602G>C	c.(601-603)CGG>CCG	p.R201P		NM_007129	NP_009060	O95409	ZIC2_HUMAN	zinc finger protein of the cerebellum 2	201	Necessary for interaction with MDFIC and transcriptional activation or repression (By similarity).				brain development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|visual perception	cytoplasm|nucleus	chromatin DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCCAGCCCGCGGACCGACCCC	0.627													0	0	0	0.001984	0	7	24										C	100634920	G	C	100634920	3	2	121	1	0	0	0	0	1	0	0	0	17676	1116	39	4	604	4	ZIC2	13	100634920	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	61369097	100634920	14534958	369	36404										
TMTC4	84899	broad.mit.edu	37	chr13	101315400	101315400	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gttgaccacgtgaaagcccaCggggtggaagcctcccgaga	14	12	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr13:101315400C>A	uc001vou.2	-	4	473	c.313G>T	c.(313-315)GTG>TTG	p.V105L	TMTC4_uc001vot.2_Missense_Mutation_p.V124L|TMTC4_uc010tja.1_Intron	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	105						integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGAAAGCCCACGGGGTGGAAG	0.562													1	0	4.10826e-27	0.00361	4.75018e-27	37	50										A	101315400	C	A	101315400	3	1	121	1	0	0	0	0	1	0	0	0	16260	536	19	4	1972	4	TMTC4	13	101315400	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	680480	101315400	13854478	370	36405										
ACIN1	22985	broad.mit.edu	37	chr14	23528466	23528466	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcgttctcggtccctttccCtatcccgatctcggtccccc	6	20	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:23528466C>T	uc001wit.3	-	19	4245	c.3917G>A	c.(3916-3918)AGG>AAG	p.R1306K	CDH24_uc001wil.2_5'Flank|CDH24_uc010akf.2_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.R548K|ACIN1_uc001wiq.3_Missense_Mutation_p.R548K|ACIN1_uc001wir.3_Missense_Mutation_p.R579K|ACIN1_uc001wis.3_Missense_Mutation_p.R987K|ACIN1_uc010akg.2_Missense_Mutation_p.R1293K	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1306	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTCCCTTTCCCTATCCCGATC	0.507											OREG0022595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	25	95										T	23528466	C	T	23528466	3	4	121	1	0	0	0	0	1	0	0	0	142	681	24	2	112	2	ACIN1	14	23528466	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		23528466	83821074	371	36406										
RABGGTA	5875	broad.mit.edu	37	chr14	24738749	24738749	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgtggtccagaatccggctgGgggtgcagctggggcaagag	19	8	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:24738749G>A	uc001wof.2	-	5	1001	c.579C>T	c.(577-579)CCC>CCT	p.P193P	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Silent_p.P193P|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	193	PFTA 4.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		AATCCGGCTGGGGGTGCAGCT	0.592													0	0	0	0.00361	0	40	156										A	24738749	G	A	24738749	2	1	121	1	0	0	0	0	0	0	0	1	12967	1219	43	2		2	RABGGTA	14	24738749	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1210283	24738749	82610791	372	36407										
ADCY4	196883	broad.mit.edu	37	chr14	24800296	24800296	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccttaggggaacactcgctGgccagccgcgtgaagcccac	12	15	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:24800296G>A	uc001wov.2	-	6	864	c.858C>T	c.(856-858)GCC>GCT	p.A286A	ADCY4_uc001wow.2_Silent_p.A286A|ADCY4_uc010toh.1_5'UTR|ADCY4_uc001wox.2_Silent_p.A286A|ADCY4_uc001woy.2_Silent_p.A286A	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	286	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		AACACTCGCTGGCCAGCCGCG	0.602													0	0	0	0.012213	0	21	29										A	24800296	G	A	24800296	2	1	121	1	0	0	0	0	0	0	0	1	296	1335	47	2		2	ADCY4	14	24800296	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	61547	24800296	82549244	373	36408										
FOXG1	2290	broad.mit.edu	37	chr14	29237880	29237880	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctttgccaagttttacgacGggactgtctgggggactgtc	13	9	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:29237880G>A	uc001wqe.2	+	1	1594	c.1395G>A	c.(1393-1395)ACG>ACA	p.T465T		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	465					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GTTTTACGACGGGACTGTCTG	0.547													0	0	0	0.00361	0	41	50										A	29237880	G	A	29237880	2	1	121	1	0	0	0	0	0	0	0	1	6007	1103	39	2		2	FOXG1	14	29237880	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4437584	29237880	78111660	374	36409										
BAZ1A	11177	broad.mit.edu	37	chr14	35240754	35240755	+	Frame_Shift_Del	DEL	CT	CT	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaacgccgctcaatgccctgCtctatttgaaagagtgccat							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:35240754_35240755delCT	uc001wsk.2	-	21	3831_3832	c.3263_3264delAG	c.(3262-3264)GAGfs	p.E1088fs	BAZ1A_uc001wsl.2_Frame_Shift_Del_p.E1056fs	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1088					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CAATGCCCTGCTCTATTTGAAA	0.366																		49	166	---	---								-	35240755	CT	-	35240754	7	5	121	1	0	1	0	1	0	0	0	0	1329	796	28	0	1434	0	BAZ1A	14	35240754	Frame_Shift_Del	DEL	CT	TCGA-GV-A3QI-01A-11D-A21Z-08	6002874	35240754	72108786	375	36410										
SOS2	6655	broad.mit.edu	37	chr14	50649252	50649252	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atcagtcatttcaactgtgtCttcaatcaaacctaaaagtt	4	9	6	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:50649252C>T	uc001wxs.3	-	6	885	c.787G>A	c.(787-789)GAC>AAC	p.D263N	SOS2_uc010tql.1_Missense_Mutation_p.D263N|SOS2_uc001wxt.2_5'Flank	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	263	DH.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TCAACTGTGTCTTCAATCAAA	0.333													0	0	0	0.001855	0	11	19										T	50649252	C	T	50649252	3	4	121	1	0	0	0	0	1	0	0	0	14937	913	32	1	3283	1	SOS2	14	50649252	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	15408498	50649252	56700288	376	36411										
C14orf101	54916	broad.mit.edu	37	chr14	57083924	57083924	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagacagaatccatcattagTatggctttttactggaatgt	8	7	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:57083924T>C	uc001xcm.2	+	9	1087	c.965T>C	c.(964-966)GTA>GCA	p.V322A	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_Intron|C14orf101_uc010trf.1_5'UTR|C14orf101_uc001xco.2_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	322	Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		CCATCATTAGTATGGCTTTTT	0.284													0	0	0	0.001368	0	9	29										C	57083924	T	C	57083924	3	2	121	1	0	0	0	0	1	0	0	0	1734	1638	57	5	999	5	C14orf101	14	57083924	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	6434672	57083924	50265616	377	36412										
SLC38A6	145389	broad.mit.edu	37	chr14	61486258	61486258	+	Splice_Site	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatatttctgttcttttacaGttggtggtggcaggcaccat	10	7	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:61486258G>C	uc001xfg.1	+	5	480	c.364_splice	c.e5-1	p.L122_splice	SLC38A6_uc001xfh.1_Splice_Site_p.L122_splice|SLC38A6_uc001xfi.2_Splice_Site|SLC38A6_uc001xfj.1_Splice_Site|SLC38A6_uc001xfk.2_Splice_Site|SLC38A6_uc010trz.1_Splice_Site_p.L99_splice	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6						amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TTCTTTTACAGTTGGTGGTGG	0.323													0	0	0	0.00278	0	20	86										C	61486258	G	C	61486258	5	2	121	1	0	0	0	0	0	0	1	0	14608	1043	36	4	381	4	SLC38A6	14	61486258	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4402334	61486258	45863282	378	36413										
SGPP1	81537	broad.mit.edu	37	chr14	64153045	64153045	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aataccatccctatgaggatCcgcaatatggcttttccaaa	6	11	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:64153045C>A	uc001xgj.2	-	3	1198	c.1104G>T	c.(1102-1104)CGG>CGT	p.R368R		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	368	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		CTATGAGGATCCGCAATATGG	0.378													1	0	1.64113e-05	0.010504	1.68672e-05	19	40										A	64153045	C	A	64153045	2	1	121	1	0	0	0	0	0	0	0	1	14219	842	30	3		3	SGPP1	14	64153045	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2666787	64153045	43196495	379	36414										
MTHFD1	4522	broad.mit.edu	37	chr14	64898301	64898301	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccatcactgcagctaataacCtcgttgctgcggccattgat	8	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:64898301C>T	uc001xhb.2	+	14	1750	c.1363C>T	c.(1363-1365)CTC>TTC	p.L455F	MTHFD1_uc010aqe.2_Missense_Mutation_p.L491F|MTHFD1_uc010aqf.2_Missense_Mutation_p.L511F	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	455	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	AGCTAATAACCTCGTTGCTGC	0.463													0	0	0	0.00361	0	40	28										T	64898301	C	T	64898301	3	4	121	1	0	0	0	0	1	0	0	0	9927	681	24	2	1417	2	MTHFD1	14	64898301	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	745256	64898301	42451239	380	36415										
TMEM229B	161145	broad.mit.edu	37	chr14	67940532	67940532	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccagggaacttccagttcaAgttcaccacgaactcccagg	8	15	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:67940532A>G	uc001xjk.2	-	3	519	c.109T>C	c.(109-111)TTG>CTG	p.L37L	TMEM229B_uc001xjj.1_RNA	NM_182526	NP_872332	Q8NBD8	T229B_HUMAN	transmembrane protein 229B	37	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						TTCCAGTTCAAGTTCACCACG	0.632													0	0	0	0.003163	0	10	17										G	67940532	A	G	67940532	2	3	121	1	0	0	0	0	0	0	0	1	16145	69	3	5		5	TMEM229B	14	67940532	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	3042231	67940532	39409008	381	36416										
ZFYVE26	23503	broad.mit.edu	37	chr14	68264756	68264756	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgatggttgcttgtcaccacCttgtgtctccactgggcctc	10	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:68264756C>G	uc001xka.2	-	11	2362	c.2223G>C	c.(2221-2223)AAG>AAC	p.K741N	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.K741N|ZFYVE26_uc010tta.1_Missense_Mutation_p.K741N	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	741					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TTGTCACCACCTTGTGTCTCC	0.542													0	0	0	0.00361	0	83	36										G	68264756	C	G	68264756	3	3	121	1	0	0	0	0	1	0	0	0	17665	680	24	4	5524	4	ZFYVE26	14	68264756	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	324224	68264756	39084784	382	36417										
KIAA0317	9870	broad.mit.edu	37	chr14	75142403	75142403	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgagaatggaaggtccaaccTttggtgacacatagcagtac	11	9	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:75142403T>A	uc001xqb.2	-	8	1584	c.1079A>T	c.(1078-1080)AAG>ATG	p.K360M	KIAA0317_uc010tut.1_Missense_Mutation_p.K199M|KIAA0317_uc001xqc.2_Missense_Mutation_p.K360M	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	360					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		AGGTCCAACCTTTGGTGACAC	0.478													0	0	0	0.00361	0	356	202										A	75142403	T	A	75142403	3	1	121	1	0	0	0	0	1	0	0	0	8167	1623	56	5	1444	5	KIAA0317	14	75142403	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	6877647	75142403	32207137	383	36418										
C14orf102	55051	broad.mit.edu	37	chr14	90767622	90767622	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctttcacgctgtcgggtttGaagaaggtgaagtccaccat	11	9	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:90767622G>C	uc001xyi.1	-	7	1537	c.1506C>G	c.(1504-1506)TTC>TTG	p.F502L	C14orf102_uc010atp.1_Missense_Mutation_p.F7L|C14orf102_uc001xyj.1_Missense_Mutation_p.F271L	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	502							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TGTCGGGTTTGAAGAAGGTGA	0.562													0	0	0	0.00361	0	42	24										C	90767622	G	C	90767622	3	2	121	1	0	0	0	0	1	0	0	0	1735	1281	45	1	2020	1	C14orf102	14	90767622	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	15625219	90767622	16581918	384	36419										
TTC7B	145567	broad.mit.edu	37	chr14	91077094	91077094	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttttattctcacctgtctcgGgatcgctgaagtctggcaaa	9	10	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:91077094G>A	uc001xyp.2	-	17	2080	c.1958C>T	c.(1957-1959)CCC>CTC	p.P653L	TTC7B_uc001xyo.2_Missense_Mutation_p.P80L|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	653							binding			ovary(2)	2		Melanoma(154;0.222)				ACCTGTCTCGGGATCGCTGAA	0.498													0	0	0	0.004482	0	8	106										A	91077094	G	A	91077094	3	1	121	1	0	0	0	0	1	0	0	0	16710	1232	43	2	589	2	TTC7B	14	91077094	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	309472	91077094	16272446	385	36420										
ASB2	51676	broad.mit.edu	37	chr14	94404063	94404063	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctgccttctccttgatgacGgcccagtcctcaaagctgtc	8	16	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:94404063G>C	uc001ycc.1	-	7	2097	c.1608C>G	c.(1606-1608)GCC>GCG	p.A536A	ASB2_uc001ycb.1_Silent_p.A230A|ASB2_uc001ycd.2_Silent_p.A584A|ASB2_uc001yce.1_Silent_p.A482A	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	536	SOCS box.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		CCTTGATGACGGCCCAGTCCT	0.617													0	0	0	0.00361	0	49	28										C	94404063	G	C	94404063	2	2	121	1	0	0	0	0	0	0	0	1	1023	1103	39	4		4	ASB2	14	94404063	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3326969	94404063	12945477	386	36421										
EML1	2009	broad.mit.edu	37	chr14	100402395	100402395	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcttagccataggctcacatGacaactgcatctatatatat	5	10	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:100402395G>A	uc001ygs.2	+	18	2008	c.1939G>A	c.(1939-1941)GAC>AAC	p.D647N	EML1_uc010tww.1_Missense_Mutation_p.D635N|EML1_uc001ygr.2_Missense_Mutation_p.D666N	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	647	WD 8.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)				AGGCTCACATGACAACTGCAT	0.423													0	0	0	0.012319	0	15	51										A	100402395	G	A	100402395	3	1	121	1	0	0	0	0	1	0	0	0	5096	1290	45	1	2070	1	EML1	14	100402395	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5998332	100402395	6947145	387	36422										
WDR20	91833	broad.mit.edu	37	chr14	102675273	102675273	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgactcagtggagctgcacGgtacgatgaaaagctacttt	11	8	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:102675273G>A	uc001ykz.2	+	3	815	c.766G>A	c.(766-768)GGT>AGT	p.G256S	WDR20_uc001yky.1_5'UTR|WDR20_uc001yla.2_Missense_Mutation_p.G132S|WDR20_uc001ylb.2_Missense_Mutation_p.G195S|WDR20_uc010txu.1_Missense_Mutation_p.G287S|WDR20_uc001ylc.2_Intron|WDR20_uc001yld.2_Missense_Mutation_p.G256S|WDR20_uc001yle.2_Missense_Mutation_p.G195S|WDR20_uc001ylf.2_Missense_Mutation_p.G268S	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	256	WD 2.										0						GGAGCTGCACGGTACGATGAA	0.557													0	0	0	0.00632	0	24	1										A	102675273	G	A	102675273	3	1	121	1	0	0	0	0	1	0	0	0	17277	1116	39	2	793	2	WDR20	14	102675273	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2272878	102675273	4674267	388	36423										
RCOR1	23186	broad.mit.edu	37	chr14	103188691	103188691	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagaagagaccaatgggcccAgtaaccagaagcctgtgaag	12	9	0	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:103188691A>T	uc001ymb.2	+	11	1348	c.1348A>T	c.(1348-1350)AGT>TGT	p.S450C		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	450					blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						CAATGGGCCCAGTAACCAGAA	0.418													0	0	0	0.00361	0	53	44										T	103188691	A	T	103188691	3	4	121	1	0	0	0	0	1	0	0	0	13182	188	7	5	1390	5	RCOR1	14	103188691	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	513418	103188691	4160849	389	36424										
AHNAK2	113146	broad.mit.edu	37	chr14	105410488	105410488	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggacgtccacctccacgctgGgcagagacacctccacatca	9	17	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr14:105410488G>A	uc010axc.1	-	7	11420	c.11300C>T	c.(11299-11301)CCC>CTC	p.P3767L	AHNAK2_uc001ypx.2_Missense_Mutation_p.P3667L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3767						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTCCACGCTGGGCAGAGACAC	0.617													0	0	0	0.00361	0	82	97										A	105410488	G	A	105410488	3	1	121	1	0	0	0	0	1	0	0	0	415	1232	43	2	6091	2	AHNAK2	14	105410488	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2221797	105410488	1939052	390	36425										
C15orf55	256646	broad.mit.edu	37	chr15	34640693	34640693	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccctggaaaaagcttggccAgggccacatgggacaaccgg	13	13	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:34640693A>G	uc001zif.2	+	2	695	c.540A>G	c.(538-540)CCA>CCG	p.P180P	C15orf55_uc010ucc.1_Silent_p.P208P|C15orf55_uc010ucd.1_Silent_p.P198P	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	180	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AAGCTTGGCCAGGGCCACATG	0.582			T	BRD3|BRD4	lethal midline carcinoma								0	0	0	0.003163	0	10	7										G	34640693	A	G	34640693	2	3	121	1	0	0	0	0	0	0	0	1	1803	175	7	5		5	C15orf55	15	34640693	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08		34640693	67890699	391	36426										
GJD2	57369	broad.mit.edu	37	chr15	35045148	35045148	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccttaacctctaaacaatctGgctctgtctccttactggtg	6	13	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:35045148G>A	uc001zis.1	-	2	497	c.497C>T	c.(496-498)CCA>CTA	p.P166L	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	166	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		TAAACAATCTGGCTCTGTCTC	0.507													0	0	0	0.00361	0	61	122										A	35045148	G	A	35045148	3	1	121	1	0	0	0	0	1	0	0	0	6417	1348	47	2	472	2	GJD2	15	35045148	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	404455	35045148	67486244	392	36427										
TP53BP1	7158	broad.mit.edu	37	chr15	43712625	43712625	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catcatcaaagagcaatttaTacttcccagctccgacatct	4	13	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:43712625T>G	uc001zrs.2	-	21	4692	c.4544A>C	c.(4543-4545)TAT>TCT	p.Y1515S	TP53BP1_uc010udp.1_Missense_Mutation_p.Y1515S|TP53BP1_uc001zrq.3_Missense_Mutation_p.Y1520S|TP53BP1_uc001zrr.3_Missense_Mutation_p.Y1520S|TP53BP1_uc010udq.1_Missense_Mutation_p.Y1520S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1515	Interaction with dimethylated histone H4.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GAGCAATTTATACTTCCCAGC	0.488								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.004656	0	19	289										G	43712625	T	G	43712625	3	3	121	1	0	0	0	0	1	0	0	0	16380	1406	49	5	1406	5	TP53BP1	15	43712625	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	8667477	43712625	58818767	393	36428										
SPATA5L1	79029	broad.mit.edu	37	chr15	45713304	45713304	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagtgaaacaagagcactttCtaaaatcacttaagactgta	6	8	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:45713304C>T	uc001zve.2	+	8	2267	c.2158C>T	c.(2158-2160)CTA>TTA	p.L720L	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	720						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		AGAGCACTTTCTAAAATCACT	0.348													0	0	0	0.000602	0	5	9										T	45713304	C	T	45713304	2	4	121	1	0	0	0	0	0	0	0	1	15011	912	32	1		1	SPATA5L1	15	45713304	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2000679	45713304	56818088	394	36429										
UNC13C	440279	broad.mit.edu	37	chr15	54306784	54306784	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aattgtgtcagtcttactcaGaagatttttcagaaaatcag	7	6	5	3	rs142320070	by1000genomes	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:54306784G>C	uc002ack.2	+	1	1684	c.1684G>C	c.(1684-1686)GAA>CAA	p.E562Q		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	562					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTCTTACTCAGAAGATTTTTC	0.423													0	0	0	0.003163	0	12	4										C	54306784	G	C	54306784	3	2	121	1	0	0	0	0	1	0	0	0	16983	943	33	1	1686	1	UNC13C	15	54306784	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8593480	54306784	48224608	395	36430										
PIGB	9488	broad.mit.edu	37	chr15	55647054	55647054	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcccgccagacctgactggaAaaagtcattatcttgatgaa	9	10	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:55647054A>G	uc002act.2	+	11	1712	c.1396A>G	c.(1396-1398)AAA>GAA	p.K466E	PIGB_uc010ugg.1_Missense_Mutation_p.K271E	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	466					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		CCTGACTGGAAAAAGTCATTA	0.378													0	0	0	0.004007	0	10	5										G	55647054	A	G	55647054	3	3	121	1	0	0	0	0	1	0	0	0	11885	15	1	5	1438	5	PIGB	15	55647054	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1340270	55647054	46884338	396	36431										
PAQR5	54852	broad.mit.edu	37	chr15	69677081	69677081	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caagaatgacagctactcctGgcccatgcttgtgtacatgt	9	11	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:69677081G>A	uc002arz.2	+	5	623	c.245G>A	c.(244-246)TGG>TAG	p.W82*	PAQR5_uc002asa.2_Nonsense_Mutation_p.W82*	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	82	Helical; Name=2; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						AGCTACTCCTGGCCCATGCTT	0.527													0	0	0	0.00361	0	53	139										A	69677081	G	A	69677081	4	1	121	1	0	0	0	0	0	1	0	0	11438	1357	47	2	255	2	PAQR5	15	69677081	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	14030027	69677081	32854311	397	36432										
TLE3	7090	broad.mit.edu	37	chr15	70389121	70389121	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcaattactcaccggatgtCtgccctgcggatacatggca	10	12	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:70389121C>G	uc002asm.2	-	1	1136	c.17G>C	c.(16-18)AGA>ACA	p.R6T	TLE3_uc002ask.2_5'Flank|TLE3_uc002asl.2_5'Flank|TLE3_uc010ukd.1_5'Flank|TLE3_uc010bik.1_Intron|TLE3_uc010bil.1_Missense_Mutation_p.R6T|TLE3_uc002asn.2_Missense_Mutation_p.R6T|TLE3_uc002asp.2_Missense_Mutation_p.R6T|TLE3_uc002aso.2_Missense_Mutation_p.R6T	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	6	Gln-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						CACCGGATGTCTGCCCTGCGG	0.592													0	0	0	0.001855	0	9	29										G	70389121	C	G	70389121	3	3	121	1	0	0	0	0	1	0	0	0	15937	913	32	1	2381	1	TLE3	15	70389121	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	712040	70389121	32142271	398	36433										
CYP1A1	1543	broad.mit.edu	37	chr15	75013618	75013618	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cctccatatagggcagatggGatctgtcagagagccggggc	15	10	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:75013618G>T	uc002ayp.3	-	5	1210	c.1088C>A	c.(1087-1089)TCC>TAC	p.S363Y	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Missense_Mutation_p.S99Y|CYP1A1_uc010bjx.2_Missense_Mutation_p.S99Y|CYP1A1_uc002ayq.3_Missense_Mutation_p.S363Y|CYP1A1_uc010bjy.2_Missense_Mutation_p.S363Y|CYP1A1_uc010bjz.1_Missense_Mutation_p.S99Y	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	363					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GGGCAGATGGGATCTGTCAGA	0.607									Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				1	0	2.70639e-06	0.002299	2.8032e-06	19	43										T	75013618	G	T	75013618	3	4	121	1	0	0	0	0	1	0	0	0	4149	1174	41	3	462	3	CYP1A1	15	75013618	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4624497	75013618	27517774	399	36434										
CSPG4	1464	broad.mit.edu	37	chr15	75981450	75981450	+	Frame_Shift_Del	DEL	G	G	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atggccaccaccttcagcgtGgccggggggctggcctgcag					rs141434179	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:75981450delG	uc002baw.2	-	3	2049	c.1956delC	c.(1954-1956)GCCfs	p.A652fs		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	652	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCTTCAGCGTGGCCGGGGGGC	0.672																		63	27	---	---								-	75981450	G	-	75981450	7	5	121	1	0	1	0	1	0	0	0	0	3960	1335	47	0	5044	0	CSPG4	15	75981450	Frame_Shift_Del	DEL	G	TCGA-GV-A3QI-01A-11D-A21Z-08	967832	75981450	26549942	400	36435										
KIAA1024	23251	broad.mit.edu	37	chr15	79748439	79748439	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttctcaatattgccaccacaGaactgacctgaagtttcagt	6	11	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:79748439G>A	uc002bew.1	+	2	26	c.-49_splice	c.e2-1		KIAA1024_uc010unk.1_5'Flank	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251							integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TGCCACCACAGAACTGACCTG	0.403													0	0	0	0.008291	0	8	6										A	79748439	G	A	79748439	5	1	121	1	0	0	0	0	0	0	1	0	8205	956	33	1		1	KIAA1024	15	79748439	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3766989	79748439	22782953	401	36436										
ADAMTSL3	57188	broad.mit.edu	37	chr15	84706492	84706492	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cactactgtatgtttgtaaaAcatcttaatttgtgttctct	5	7	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr15:84706492A>T	uc002bjz.3	+	30	5234	c.5010A>T	c.(5008-5010)AAA>AAT	p.K1670N	ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1670	PLAC.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGTTTGTAAAACATCTTAATT	0.373													0	0	0	0.00623	0	30	38										T	84706492	A	T	84706492	3	4	121	1	0	0	0	0	1	0	0	0	276	40	2	5	5124	5	ADAMTSL3	15	84706492	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4958053	84706492	17824900	402	36437										
IL32	9235	broad.mit.edu	37	chr16	3117416	3117416	+	Frame_Shift_Del	DEL	G	G	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagaagctgaaggcccgaatGgtaatgctcctccctacttc							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:3117416delG	uc002cto.2	+	3	265	c.54delG	c.(52-54)ATGfs	p.M18fs	IL32_uc002ctk.2_Frame_Shift_Del_p.M18fs|IL32_uc010uwp.1_Frame_Shift_Del_p.M18fs|IL32_uc010btb.2_Frame_Shift_Del_p.M8fs|IL32_uc002ctl.2_Frame_Shift_Del_p.M18fs|IL32_uc002ctm.2_Frame_Shift_Del_p.M18fs|IL32_uc002ctn.2_Frame_Shift_Del_p.M18fs|IL32_uc010btc.1_Frame_Shift_Del_p.M18fs|IL32_uc002cts.3_Frame_Shift_Del_p.M18fs|IL32_uc002ctp.2_Frame_Shift_Del_p.M18fs|IL32_uc010uwq.1_Frame_Shift_Del_p.M18fs|IL32_uc002ctq.2_Frame_Shift_Del_p.M18fs|IL32_uc002ctr.2_Frame_Shift_Del_p.M18fs|IL32_uc002ctt.2_Frame_Shift_Del_p.M18fs|IL32_uc010uwr.1_Frame_Shift_Del_p.M18fs|IL32_uc002ctu.2_Frame_Shift_Del_p.M18fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	18					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						AGGCCCGAATGGTAATGCTCC	0.552																		31	61	---	---								-	3117416	G	-	3117416	7	5	121	1	0	1	0	1	0	0	0	0	7692	1362	47	0	60	0	IL32	16	3117416	Frame_Shift_Del	DEL	G	TCGA-GV-A3QI-01A-11D-A21Z-08		3117416	87237337	403	36438										
TXNDC11	51061	broad.mit.edu	37	chr16	11794368	11794368	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagtgtactaaggataccagTttcgcaagatgtttatttgt	10	5	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:11794368T>A	uc010buu.1	-	7	989	c.927A>T	c.(925-927)AAA>AAT	p.K309N	TXNDC11_uc002dbg.1_Missense_Mutation_p.K282N	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	309					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						AGGATACCAGTTTCGCAAGAT	0.328													0	0	0	0.00361	0	45	26										A	11794368	T	A	11794368	3	1	121	1	0	0	0	0	1	0	0	0	16789	1722	60	5	2058	5	TXNDC11	16	11794368	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	8676952	11794368	78560385	404	36439										
PDILT	204474	broad.mit.edu	37	chr16	20380853	20380853	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aagctgcggccaaatttcttGaggctttcgtaggttatgtc	11	8	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:20380853G>A	uc002dhc.1	-	8	1300	c.1077C>T	c.(1075-1077)CTC>CTT	p.L359L		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	359					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						CAAATTTCTTGAGGCTTTCGT	0.443													0	0	0	0.00361	0	52	31										A	20380853	G	A	20380853	2	1	121	1	0	0	0	0	0	0	0	1	11674	1277	45	1		1	PDILT	16	20380853	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8586485	20380853	69973900	405	36440										
SULT1A1	6817	broad.mit.edu	37	chr16	28617545	28617545	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctccaggatcttttgaatctCccttttcgggttctgagcag	9	11	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:28617545C>G	uc002dqi.2	-	6	1080	c.607G>C	c.(607-609)GAG>CAG	p.E203Q	uc010vct.1_Intron|SULT1A1_uc002dqj.2_Missense_Mutation_p.E203Q|SULT1A1_uc002dqk.2_Missense_Mutation_p.E203Q|SULT1A1_uc002dql.2_Missense_Mutation_p.E203Q|SULT1A1_uc002dqm.2_Missense_Mutation_p.E125Q|SULT1A1_uc002dqn.2_Missense_Mutation_p.E294Q|SULT1A1_uc002dqo.2_Missense_Mutation_p.E203Q|SULT1A1_uc002dqp.2_Missense_Mutation_p.E203Q	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,	203	PAPS.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						TTTTGAATCTCCCTTTTCGGG	0.542													0	0	0	0.001368	0	9	2										G	28617545	C	G	28617545	3	3	121	1	0	0	0	0	1	0	0	0	15371	864	30	1	288	1	SULT1A1	16	28617545	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	8236692	28617545	61737208	406	36441										
ATP2A1	487	broad.mit.edu	37	chr16	28911941	28911941	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgtagtgggcatgctggacCctccgcgcaaggaggtcacg	16	11	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:28911941C>A	uc002dro.1	+	15	1988	c.1804C>A	c.(1804-1806)CCT>ACT	p.P602T	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.P602T|ATP2A1_uc002drp.1_Missense_Mutation_p.P477T	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	602	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CATGCTGGACCCTCCGCGCAA	0.612													1	0	2.78669e-64	0.00361	3.31417e-64	69	46										A	28911941	C	A	28911941	3	1	121	1	0	0	0	0	1	0	0	0	1136	623	22	4	1862	4	ATP2A1	16	28911941	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	294396	28911941	61442812	407	36442										
ATP2A1	487	broad.mit.edu	37	chr16	28911981	28911981	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gggctccatccagctgtgccGtgacgccgggatccgggtga	16	13	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:28911981G>A	uc002dro.1	+	15	2028	c.1844G>A	c.(1843-1845)CGT>CAT	p.R615H	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.R615H|ATP2A1_uc002drp.1_Missense_Mutation_p.R490H	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	615	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAGCTGTGCCGTGACGCCGGG	0.612													0	0	0	0.00361	0	50	42										A	28911981	G	A	28911981	3	1	121	1	0	0	0	0	1	0	0	0	1136	1145	40	2	1902	2	ATP2A1	16	28911981	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	40	28911981	61442772	408	36443										
CD19	930	broad.mit.edu	37	chr16	28947484	28947484	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcccaccagccctggtcctGaggaggaaaagaaagcgaat	11	12	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:28947484G>C	uc002drs.2	+	6	1019	c.957G>C	c.(955-957)CTG>CTC	p.L319L	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.L319L	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	319	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						CCCTGGTCCTGAGGAGGAAAA	0.547													0	0	0	0.007291	0	22	52										C	28947484	G	C	28947484	2	2	121	1	0	0	0	0	0	0	0	1	2973	1277	45	1		1	CD19	16	28947484	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	35503	28947484	61407269	409	36444										
ZNF646	9726	broad.mit.edu	37	chr16	31090894	31090894	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggagactttctctgccctgtCtgctcccgctgctaccccaa	8	17	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:31090894C>T	uc002eap.2	+	2	3538	c.3249C>T	c.(3247-3249)GTC>GTT	p.V1083V		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1083	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TCTGCCCTGTCTGCTCCCGCT	0.627													0	0	0	0.00361	0	129	272										T	31090894	C	T	31090894	2	4	121	1	0	0	0	0	0	0	0	1	18059	900	32	1		1	ZNF646	16	31090894	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2143410	31090894	59263859	410	36445										
COX6A2	1339	broad.mit.edu	37	chr16	31439103	31439103	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcgtccggggcctcaggggtGttcgtagcccgtgggcagag	19	11	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:31439103G>T	uc002ebx.1	-	3	361	c.286C>A	c.(286-288)CAC>AAC	p.H96N		NM_005205	NP_005196	Q02221	CX6A2_HUMAN	cytochrome c oxidase subunit VIa polypeptide 2	96					generation of precursor metabolites and energy	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0						CCTCAGGGGTGTTCGTAGCCC	0.682													1	0	2.7689e-08	0.001984	2.90865e-08	5	8										T	31439103	G	T	31439103	3	4	121	1	0	0	0	0	1	0	0	0	3775	1377	48	4	11	4	COX6A2	16	31439103	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	348209	31439103	58915650	411	36446										
ARMC5	79798	broad.mit.edu	37	chr16	31476086	31476086	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgcaaccctgcctgcctcgAggccttcgtgcgcagctatg	11	16	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:31476086A>C	uc002ecc.2	+	4	2271	c.1742A>C	c.(1741-1743)GAG>GCG	p.E581A	ARMC5_uc010vfn.1_Missense_Mutation_p.E676A|ARMC5_uc010vfo.1_Missense_Mutation_p.E613A|ARMC5_uc002eca.3_Missense_Mutation_p.E581A|ARMC5_uc010vfp.1_Missense_Mutation_p.E389A|ARMC5_uc002ecb.2_Missense_Mutation_p.E581A	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	581							binding			pancreas(1)	1						GCCTGCCTCGAGGCCTTCGTG	0.716													0	0	0	0.001168	0	5	13										C	31476086	A	C	31476086	3	2	121	1	0	0	0	0	1	0	0	0	954	304	11	5	1756	5	ARMC5	16	31476086	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	36983	31476086	58878667	412	36447										
CX3CL1	6376	broad.mit.edu	37	chr16	57416799	57416799	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggggctgctggccttccttgGcctcctcttctgcctggggg	15	14	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:57416799G>T	uc002eli.2	+	3	1116	c.1049G>T	c.(1048-1050)GGC>GTC	p.G350V		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	350	Helical; (Potential).				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GCCTTCCTTGGCCTCCTCTTC	0.667													1	0	0.000132079	0.008871	0.000135122	14	2										T	57416799	G	T	57416799	3	4	121	1	0	0	0	0	1	0	0	0	4074	1203	42	4	1059	4	CX3CL1	16	57416799	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	25940713	57416799	32937954	413	36448										
GPR56	9289	broad.mit.edu	37	chr16	57685294	57685294	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgcttcccgatccttccctGaccccaggggcctctaccac	7	20	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:57685294G>T	uc002emb.2	+	4	539	c.247G>T	c.(247-249)GAC>TAC	p.D83Y	GPR56_uc002elz.1_Intron|GPR56_uc002ema.1_5'UTR|GPR56_uc002emc.2_Missense_Mutation_p.D83Y|GPR56_uc002emf.2_Missense_Mutation_p.D83Y|GPR56_uc010vhs.1_Missense_Mutation_p.D83Y|GPR56_uc002emd.2_Missense_Mutation_p.D83Y|GPR56_uc002eme.2_Missense_Mutation_p.D83Y|GPR56_uc010vht.1_Missense_Mutation_p.D88Y|GPR56_uc002emg.3_Missense_Mutation_p.D83Y|GPR56_uc010vhu.1_5'UTR	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	83	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						ATCCTTCCCTGACCCCAGGGG	0.577													1	0	1.52319e-26	0.00874	1.75813e-26	32	4										T	57685294	G	T	57685294	3	4	121	1	0	0	0	0	1	0	0	0	6700	1290	45	3	268	3	GPR56	16	57685294	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	268495	57685294	32669459	414	36449										
SLC9A5	6553	broad.mit.edu	37	chr16	67290524	67290524	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catctcagccgtggactcttCtaagtgggcctgggattctg	12	11	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:67290524C>A	uc002esm.2	+	6	1127	c.1064C>A	c.(1063-1065)TCT>TAT	p.S355Y	SLC9A5_uc010cee.2_Missense_Mutation_p.S60Y|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	355					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GTGGACTCTTCTAAGTGGGCC	0.537													1	0	5.41189e-41	0.00361	6.37933e-41	56	3										A	67290524	C	A	67290524	3	1	121	1	0	0	0	0	1	0	0	0	14717	913	32	3	1086	3	SLC9A5	16	67290524	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9605230	67290524	23064229	415	36450										
ACD	65057	broad.mit.edu	37	chr16	67693135	67693135	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtcaagctctacagtacctgCattggacgaggtggactctg	12	10	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:67693135C>T	uc002etq.3	-	6	1085	c.748G>A	c.(748-750)GCA>ACA	p.A250T	ACD_uc002etp.3_Missense_Mutation_p.A247T|ACD_uc002etr.3_Missense_Mutation_p.A247T|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	250	Interaction with POT1.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		ACAGTACCTGCATTGGACGAG	0.532													0	0	0	0.00361	0	67	4										T	67693135	C	T	67693135	3	4	121	1	0	0	0	0	1	0	0	0	135	710	25	2	914	2	ACD	16	67693135	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	402611	67693135	22661618	416	36451										
NFAT5	10725	broad.mit.edu	37	chr16	69729203	69729203	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catcctctataaacaccaacCagaacatcgaaaagattgat	4	11	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:69729203C>A	uc002exm.1	+	13	5733	c.4525C>A	c.(4525-4527)CAG>AAG	p.Q1509K	NFAT5_uc002exi.2_Missense_Mutation_p.Q1433K|NFAT5_uc002exj.1_Missense_Mutation_p.Q1433K|NFAT5_uc002exk.1_Missense_Mutation_p.Q1433K|NFAT5_uc002exl.1_Missense_Mutation_p.Q1527K|NFAT5_uc002exn.1_Missense_Mutation_p.Q1526K|NFAT5_uc002exo.1_Intron	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	1509					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AAACACCAACCAGAACATCGA	0.438													1	0	1.53716e-24	0.00361	1.77119e-24	45	0										A	69729203	C	A	69729203	3	1	121	1	0	0	0	0	1	0	0	0	10360	595	21	4	4633	4	NFAT5	16	69729203	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2036068	69729203	20625550	417	36452										
VAT1L	57687	broad.mit.edu	37	chr16	77896683	77896683	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgtgttccactgtccccaaCgtgactgtctttggaacagc	9	13	1	1	rs147711332		TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr16:77896683C>T	uc002ffg.1	+	4	715	c.618C>T	c.(616-618)AAC>AAT	p.N206N		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	206							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						CTGTCCCCAACGTGACTGTCT	0.478													0	0	0	0.00361	0	54	4										T	77896683	C	T	77896683	2	4	121	1	0	0	0	0	0	0	0	1	17127	535	19	2		2	VAT1L	16	77896683	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	8167480	77896683	12458070	418	36453										
OR1A2	26189	broad.mit.edu	37	chr17	3100986	3100986	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gacattcgccttcacaacccCatgtattttctccttgccaa	4	15	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:3100986C>T	uc002fvd.1	+	1	174	c.174C>T	c.(172-174)CCC>CCT	p.P58P		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TTCACAACCCCATGTATTTTC	0.463													0	0	0	0.00361	0	112	168										T	3100986	C	T	3100986	2	4	121	1	0	0	0	0	0	0	0	1	10950	581	21	2		2	OR1A2	17	3100986	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		3100986	78094224	419	36454										
TRPV1	7442	broad.mit.edu	37	chr17	3477062	3477062	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggatgatgaagacagccttGaagtcatagttctcagtgaa	11	6	2	5			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:3477062G>C	uc010vrr.1	-	12	2495	c.1968C>G	c.(1966-1968)TTC>TTG	p.F656L	TRPV1_uc010vro.1_Missense_Mutation_p.F667L|TRPV1_uc010vrp.1_Missense_Mutation_p.F596L|TRPV1_uc010vrq.1_Missense_Mutation_p.F654L|TRPV1_uc010vrs.1_Missense_Mutation_p.F656L|TRPV1_uc010vrt.1_Missense_Mutation_p.F656L|TRPV1_uc010vru.1_Missense_Mutation_p.F656L	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	656					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	AGACAGCCTTGAAGTCATAGT	0.527													0	0	0	0.00623	0	34	50										C	3477062	G	C	3477062	3	2	121	1	0	0	0	0	1	0	0	0	16592	1281	45	1		1	TRPV1	17	3477062	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	376076	3477062	77718148	420	36455										
ZZEF1	23140	broad.mit.edu	37	chr17	3919633	3919633	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttacctcgaagttggtgttgTtgttatacgggtgtttcgac	12	6	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:3919633T>C	uc002fxe.2	-	49	8193	c.8129A>G	c.(8128-8130)AAC>AGC	p.N2710S	ZZEF1_uc002fxg.1_Missense_Mutation_p.N31S	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2710							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GTTGGTGTTGTTGTTATACGG	0.612													0	0	0	0.00361	0	37	48										C	3919633	T	C	3919633	3	2	121	1	0	0	0	0	1	0	0	0	18252	1725	60	5	784	5	ZZEF1	17	3919633	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	442571	3919633	77275577	421	36456										
MINK1	50488	broad.mit.edu	37	chr17	4797304	4797304	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcgatggggatacagacagCgtcagcaccatggtggtcca	14	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:4797304C>T	uc010vsl.1	+	22	2782	c.2586C>T	c.(2584-2586)AGC>AGT	p.S862S	MINK1_uc010vsk.1_Silent_p.S833S|MINK1_uc010vsm.1_Silent_p.S842S|MINK1_uc010vsn.1_Silent_p.S825S|MINK1_uc010vso.1_Silent_p.S770S|MINK1_uc010vsp.1_Silent_p.S323S	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	862					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						ATACAGACAGCGTCAGCACCA	0.657													0	0	0	0.008291	0	6	11										T	4797304	C	T	4797304	2	4	121	1	0	0	0	0	0	0	0	1	9587	767	27	2		2	MINK1	17	4797304	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	877671	4797304	76397906	422	36457										
KIAA0753	9851	broad.mit.edu	37	chr17	6493200	6493200	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tagtcaccgatgctgtgctgCatacccggtgggacaaagag	13	10	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:6493200C>T	uc002gde.3	-	18	3044	c.2685G>A	c.(2683-2685)ATG>ATA	p.M895I	KIAA0753_uc010vtd.1_Missense_Mutation_p.M351I|KIAA0753_uc010clo.2_Missense_Mutation_p.M596I|KIAA0753_uc010vte.1_Missense_Mutation_p.M596I	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	895						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		TGCTGTGCTGCATACCCGGTG	0.522													0	0	0	0.009535	0	24	30										T	6493200	C	T	6493200	3	4	121	1	0	0	0	0	1	0	0	0	8191	710	25	2	226	2	KIAA0753	17	6493200	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1695896	6493200	74702010	423	36458										
XAF1	54739	broad.mit.edu	37	chr17	6674105	6674105	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgtccaaagacaagaagtatAaacagatttcctcttcattc	5	10	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:6674105A>T	uc002gdn.2	+	6	893	c.651A>T	c.(649-651)ATA>ATT	p.I217I	XAF1_uc002gdm.1_Silent_p.I157I|XAF1_uc002gdo.2_Silent_p.I198I|XAF1_uc002gdp.2_Silent_p.I166I|XAF1_uc002gdq.2_Silent_p.I49I|XAF1_uc002gdr.2_Silent_p.I147I	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	217					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						CAAGAAGTATAAACAGATTTC	0.398													0	0	0	0.012319	0	18	13										T	6674105	A	T	6674105	2	4	121	1	0	0	0	0	0	0	0	1	17416	352	13	5		5	XAF1	17	6674105	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	180905	6674105	74521105	424	36459										
C17orf74	201243	broad.mit.edu	37	chr17	7330284	7330284	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggagggctttgagcgcccccCtgcctcggtgtcccggaacg	15	15	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:7330284C>A	uc002ggw.2	+	3	1047	c.974C>A	c.(973-975)CCT>CAT	p.P325H	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	325						integral to membrane					0		Prostate(122;0.157)				GAGCGCCCCCCTGCCTCGGTG	0.697													1	0	3.01185e-09	0.003954	3.19409e-09	23	12										A	7330284	C	A	7330284	3	1	121	1	0	0	0	0	1	0	0	0	1879	681	24	4	984	4	C17orf74	17	7330284	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	656179	7330284	73864926	425	36460										
CHD3	1107	broad.mit.edu	37	chr17	7800409	7800409	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgccctgctagctggaaatCttccatttggttatgtatcg	10	9	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:7800409C>G	uc002gje.2	+	11	1866	c.1716C>G	c.(1714-1716)ATC>ATG	p.I572M	CHD3_uc002gjd.2_Missense_Mutation_p.I631M|CHD3_uc002gjf.2_Missense_Mutation_p.I572M|CHD3_uc002gjg.1_Missense_Mutation_p.I400M	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	572	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				AGCTGGAAATCTTCCATTTGG	0.532													0	0	0	0.010729	0	9	43										G	7800409	C	G	7800409	3	3	121	1	0	0	0	0	1	0	0	0	3326	903	32	1	2039	1	CHD3	17	7800409	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	470125	7800409	73394801	426	36461										
COX10	1352	broad.mit.edu	37	chr17	13977769	13977769	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcactttagcttcctcaaacGcatggtatgtttagaagacc	8	10	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:13977769G>A	uc002gof.3	+	2	377	c.173G>A	c.(172-174)CGC>CAC	p.R58H	COX10_uc010vvs.1_5'UTR|COX10_uc010vvt.1_5'UTR	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	58					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		TTCCTCAAACGCATGGTATGT	0.348													0	0	0	0.00361	0	77	110										A	13977769	G	A	13977769	3	1	121	1	0	0	0	0	1	0	0	0	3762	1087	38	2	179	2	COX10	17	13977769	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6177360	13977769	67217441	427	36462										
RAI1	10743	broad.mit.edu	37	chr17	17697690	17697690	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccaggaccccagagcagcaTaaaagccagcactgcagccc	9	16	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:17697690T>G	uc002grm.2	+	3	1897	c.1428T>G	c.(1426-1428)CAT>CAG	p.H476Q	RAI1_uc002grn.1_Missense_Mutation_p.H476Q	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	476						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CAGAGCAGCATAAAAGCCAGC	0.627													0	0	0	0.001855	0	9	27										G	17697690	T	G	17697690	3	3	121	1	0	0	0	0	1	0	0	0	13007	1403	49	5	1430	5	RAI1	17	17697690	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	3719921	17697690	63497520	428	36463										
CCDC144B	284047	broad.mit.edu	37	chr17	18513402	18513402	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tagctgtgattggcacaggtCatggagagtatcattccctg	12	8	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:18513402C>A	uc002gub.1	-	3	704	c.619G>T	c.(619-621)GAC>TAC	p.D207Y	CCDC144B_uc002gua.3_RNA|CCDC144B_uc010vyc.1_RNA|CCDC144B_uc002guc.1_Missense_Mutation_p.D207Y	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2						TGGCACAGGTCATGGAGAGTA	0.433													1	0	1.61004e-24	0.00361	1.85196e-24	42	95										A	18513402	C	A	18513402	3	1	121	1	0	0	0	0	1	0	0	0	2778	826	29	3	1589	3	CCDC144B	17	18513402	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	815712	18513402	62681808	429	36464										
MAPK7	5598	broad.mit.edu	37	chr17	19286175	19286175	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aggcacaccaaagggcagtgGggctggctacggtgttggct	17	9	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:19286175G>A	uc002gvn.2	+	6	2599	c.2213G>A	c.(2212-2214)GGG>GAG	p.G738E	MAPK7_uc002gvo.2_Missense_Mutation_p.G599E|MAPK7_uc002gvq.2_Missense_Mutation_p.G738E|MAPK7_uc002gvp.2_Missense_Mutation_p.G738E|uc010vyt.1_5'Flank	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	738	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					AAGGGCAGTGGGGCTGGCTAC	0.577													0	0	0	0.00361	0	60	68										A	19286175	G	A	19286175	3	1	121	1	0	0	0	0	1	0	0	0	9282	1232	43	2	2231	2	MAPK7	17	19286175	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	772773	19286175	61909035	430	36465										
ACACA	31	broad.mit.edu	37	chr17	35454054	35454054	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcctccagcagaagacgcctCagccgccagtagaagaaggt	11	13	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:35454054C>G	uc002hnm.2	-	54	6848	c.6657G>C	c.(6655-6657)CTG>CTC	p.L2219L	ACACA_uc002hnk.2_Silent_p.L2141L|ACACA_uc002hnl.2_Silent_p.L2161L|ACACA_uc002hnn.2_Silent_p.L2219L|ACACA_uc002hno.2_Silent_p.L2256L|ACACA_uc010cuy.2_Silent_p.L864L|ACACA_uc010wdb.1_Silent_p.L257L|ACACA_uc010wdc.1_Silent_p.L345L	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2219					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAAGACGCCTCAGCCGCCAGT	0.488													0	0	0	0.00278	0	19	11										G	35454054	C	G	35454054	2	3	121	1	0	0	0	0	0	0	0	1	106	813	29	1		1	ACACA	17	35454054	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	16167879	35454054	45741156	431	36466										
KRT222	125113	broad.mit.edu	37	chr17	38812797	38812797	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	taaatgaagatcaaatcgaaGagaaacagactttttcctca	6	7	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:38812797G>C	uc002hvc.2	-	6	810	c.745C>G	c.(745-747)CTT>GTT	p.L249V	KRT222_uc010wfk.1_RNA|KRT222_uc002hvb.2_Missense_Mutation_p.L209V	NM_152349	NP_689562	Q8N1A0	KT222_HUMAN	truncated type I keratin KA21	249						intermediate filament	structural molecule activity			central_nervous_system(1)|skin(1)	2						TCAAATCGAAGAGAAACAGAC	0.363													0	0	0	0.004656	0	23	34										C	38812797	G	C	38812797	3	2	121	1	0	0	0	0	1	0	0	0	8459	942	33	1	146	1	KRT222	17	38812797	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3358743	38812797	42382413	432	36467										
KRTAP3-1	83896	broad.mit.edu	37	chr17	39165064	39165064	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cacagggactctcacagccaGgctgaacataggtggtcagg	13	11	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:39165064G>A	uc002hvt.1	-	1	303	c.263C>T	c.(262-264)CCT>CTT	p.P88L		NM_031958	NP_114164	Q9BYR8	KRA31_HUMAN	keratin associated protein 3.1	88						keratin filament	structural molecule activity				0		Breast(137;0.00043)				CTCACAGCCAGGCTGAACATA	0.582													0	0	0	0.002299	0	19	42										A	39165064	G	A	39165064	3	1	121	1	0	0	0	0	1	0	0	0	8545	1000	35	2	37	2	KRTAP3-1	17	39165064	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	352267	39165064	42030146	433	36468										
KRT36	8689	broad.mit.edu	37	chr17	39646100	39646100	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagtggagaaggtaggggtgCaggtctgggtggccatggtg	21	5	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:39646100C>T	uc002hwt.2	-	1	17	c.17G>A	c.(16-18)TGC>TAC	p.C6Y		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	6	Head.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				GGTAGGGGTGCAGGTCTGGGT	0.582													0	0	0	0.006214	0	9	37										T	39646100	C	T	39646100	3	4	121	1	0	0	0	0	1	0	0	0	8473	710	25	2	1414	2	KRT36	17	39646100	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	481036	39646100	41549110	434	36469										
KAT2A	2648	broad.mit.edu	37	chr17	40269467	40269468	+	Frame_Shift_Ins	INS	-	-	A													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggcagctggtgggaaaagacINSattctgcagccccacgagcc							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:40269467_40269468insA	uc002hyx.2	-	10	1635_1636	c.1575_1576insT	c.(1573-1578)AATGTCfs	p.N525fs		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	525_526	N-acetyltransferase.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						TGGGAAAAGACATTCTGCAGCC	0.644																		13	58	---	---								A	40269468	-	A	40269467	7	5	121	1	0	1	1	0	0	0	0	0	7981	478	17	0	973	0	KAT2A	17	40269467	Frame_Shift_Ins	INS	-	TCGA-GV-A3QI-01A-11D-A21Z-08	623367	40269467	40925743	435	36470										
ATP6V0A1	535	broad.mit.edu	37	chr17	40635081	40635081	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagcctcactctatccctgtCctgagacaccacaggagagg	10	14	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:40635081C>A	uc002hzr.2	+	9	909	c.742C>A	c.(742-744)CCT>ACT	p.P248T	ATP6V0A1_uc002hzq.2_Missense_Mutation_p.P248T|ATP6V0A1_uc002hzs.2_Missense_Mutation_p.P255T|ATP6V0A1_uc010wgj.1_Missense_Mutation_p.P205T|ATP6V0A1_uc010wgk.1_Missense_Mutation_p.P205T|ATP6V0A1_uc010cyg.2_Intron|ATP6V0A1_uc010wgl.1_Missense_Mutation_p.P107T	NM_001130021	NP_001123493	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	248	Cytoplasmic (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		CTATCCCTGTCCTGAGACACC	0.408													1	0	3.51602e-12	0.008871	3.82001e-12	16	50										A	40635081	C	A	40635081	3	1	121	1	0	0	0	0	1	0	0	0	1168	855	30	3	793	3	ATP6V0A1	17	40635081	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	365614	40635081	40560129	436	36471										
IMP5	162540	broad.mit.edu	37	chr17	43922946	43922946	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgaagaggaggggggtctgGtggtcaccatcagctgcagg	18	9	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:43922946G>A	uc010wka.1	+	1	674	c.674G>A	c.(673-675)GGT>GAT	p.G225D	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	225	Cytoplasmic (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		GGGGGGTCTGGTGGTCACCAT	0.652													0	0	0	0.004482	0	9	12										A	43922946	G	A	43922946	3	1	121	1	0	0	0	0	1	0	0	0	7721	1261	44	2	676	2	IMP5	17	43922946	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3287865	43922946	37272264	437	36472										
MAPT	4137	broad.mit.edu	37	chr17	44067379	44067379	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagagccaccttcctctcctAaatacgtctcttctgtcact	4	16	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:44067379A>G	uc002ijr.3	+	8	1638	c.1318A>G	c.(1318-1320)AAA>GAA	p.K440E	MAPT_uc010dau.2_Missense_Mutation_p.K440E|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	440					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				TTCCTCTCCTAAATACGTCTC	0.537													0	0	0	0.00361	0	107	117										G	44067379	A	G	44067379	3	3	121	1	0	0	0	0	1	0	0	0	9297	363	13	5	1344	5	MAPT	17	44067379	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	144433	44067379	37127831	438	36473										
KPNB1	3837	broad.mit.edu	37	chr17	45752045	45752045	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catcaagatgctttgcagatCtctgatgtggttatggcctc	10	9	2	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:45752045C>G	uc002ilt.1	+	15	2145	c.1809C>G	c.(1807-1809)ATC>ATG	p.I603M	KPNB1_uc010wkw.1_Missense_Mutation_p.I458M|KPNB1_uc010wkx.1_Missense_Mutation_p.I387M	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	603	HEAT 7.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTTGCAGATCTCTGATGTGG	0.463													0	0	0	0.004007	0	13	200										G	45752045	C	G	45752045	3	3	121	1	0	0	0	0	1	0	0	0	8435	903	32	1	1867	1	KPNB1	17	45752045	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1684666	45752045	35443165	439	36474										
LPO	4025	broad.mit.edu	37	chr17	56327830	56327830	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgaatgaggagggtgttctgGaccaaaacaggtccctgctc	13	9	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:56327830G>A	uc002ivt.2	+	7	944	c.628G>A	c.(628-630)GAC>AAC	p.D210N	LPO_uc010dco.2_Missense_Mutation_p.D210N|LPO_uc010wnr.1_Missense_Mutation_p.D127N|LPO_uc010wns.1_Missense_Mutation_p.D151N|LPO_uc010dcp.2_Missense_Mutation_p.D127N|LPO_uc010dcq.2_5'UTR|LPO_uc010dcr.2_5'Flank	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	210					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						GGGTGTTCTGGACCAAAACAG	0.527													0	0	0	0.005443	0	24	47										A	56327830	G	A	56327830	3	1	121	1	0	0	0	0	1	0	0	0	8922	1174	41	1	650	1	LPO	17	56327830	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	10575785	56327830	24867380	440	36475										
MRC2	9902	broad.mit.edu	37	chr17	60755974	60755974	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggccagctacgaggaggagcActttgtggccaacatgctca	13	11	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:60755974A>T	uc002jad.2	+	13	2564	c.2162A>T	c.(2161-2163)CAC>CTC	p.H721L	MRC2_uc010ddq.1_RNA|MRC2_uc002jae.2_5'Flank|MRC2_uc002jaf.2_5'Flank	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	721	Extracellular (Potential).|C-type lectin 4.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GAGGAGGAGCACTTTGTGGCC	0.647													0	0	0	0.010729	0	10	38										T	60755974	A	T	60755974	3	4	121	1	0	0	0	0	1	0	0	0	9758	159	6	5	2212	5	MRC2	17	60755974	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4428144	60755974	20439236	441	36476										
CCDC46	201134	broad.mit.edu	37	chr17	63848079	63848079	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaccaagctctaccagctgcTgtttccgctgtgagttcaca	9	13	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:63848079T>G	uc002jfl.2	-	21	2456	c.2237A>C	c.(2236-2238)CAG>CCG	p.Q746P	CCDC46_uc010deo.2_Missense_Mutation_p.Q488P|CCDC46_uc002jfm.2_Missense_Mutation_p.Q746P|CCDC46_uc010dep.2_Missense_Mutation_p.Q704P	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	746	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			TACCAGCTGCTGTTTCCGCTG	0.403													0	0	0	0.005524	0	30	15										G	63848079	T	G	63848079	3	3	121	1	0	0	0	0	1	0	0	0	2817	1580	55	5	824	5	CCDC46	17	63848079	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	3092105	63848079	17347131	442	36477										
KCNJ2	3759	broad.mit.edu	37	chr17	68171368	68171368	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcagttcatcaatgtgggtgAgaaggggcaacggtacctcg	14	8	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:68171368A>G	uc010dfg.2	+	2	589	c.188A>G	c.(187-189)GAG>GGG	p.E63G	KCNJ2_uc002jir.2_Missense_Mutation_p.E63G	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	63	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					AATGTGGGTGAGAAGGGGCAA	0.527													0	0	0	0.004482	0	6	75										G	68171368	A	G	68171368	3	3	121	1	0	0	0	0	1	0	0	0	8051	304	11	5	190	5	KCNJ2	17	68171368	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	4323289	68171368	13023842	443	36478										
ITGB4	3691	broad.mit.edu	37	chr17	73746222	73746222	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccggagcttcacgagtcagaTgttgtcatcacagccacccc	9	15	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:73746222T>A	uc002jpg.2	+	28	3534	c.3347T>A	c.(3346-3348)ATG>AAG	p.M1116K	ITGB4_uc002jph.2_Missense_Mutation_p.M1116K|ITGB4_uc002jpi.3_Missense_Mutation_p.M1116K|ITGB4_uc002jpj.2_Missense_Mutation_p.M1116K	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1116	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAGTCAGATGTTGTCATCA	0.632											OREG0024739	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	18	78										A	73746222	T	A	73746222	3	1	121	1	0	0	0	0	1	0	0	0	7897	1464	51	5	3453	5	ITGB4	17	73746222	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	5574854	73746222	7448988	444	36479										
DNAH17	8632	broad.mit.edu	37	chr17	76554223	76554223	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccaacgatgagctccaggttGcccacaaacttccggaaagt	9	13	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:76554223G>A	uc002jvv.1	-	10	1357	c.1251C>T	c.(1249-1251)GGC>GGT	p.G417G						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GCTCCAGGTTGCCCACAAACT	0.433													0	0	0	0.008871	0	13	11										A	76554223	G	A	76554223	2	1	121	1	0	0	0	0	0	0	0	1	4601	1306	46	2		2	DNAH17	17	76554223	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	2808001	76554223	4640987	445	36480										
CARD14	79092	broad.mit.edu	37	chr17	78179329	78179329	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccgtccaatgtcacctgtaGagtacttgagccaggaggag	12	11	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:78179329G>C	uc002jxw.1	+	19	2765	c.2570_splice	c.e19-1	p.E857_splice	CARD14_uc002jxt.1_Splice_Site	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1						activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GTCACCTGTAGAGTACTTGAG	0.632													0	0	0	0.009096	0	3	8										C	78179329	G	C	78179329	5	2	121	1	0	0	0	0	0	0	1	0	2646	956	33	1	2804	1	CARD14	17	78179329	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1625106	78179329	3015881	446	36481										
PCYT2	5833	broad.mit.edu	37	chr17	79866776	79866776	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgaacacagaagtcacagtTgtatttgtccagggtctcta	10	8	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:79866776T>G	uc002kcf.1	-	3	379	c.316A>C	c.(316-318)AAC>CAC	p.N106H	PCYT2_uc010wva.1_Missense_Mutation_p.N74H|PCYT2_uc010wvb.1_Missense_Mutation_p.N74H|PCYT2_uc002kce.1_Missense_Mutation_p.N28H|PCYT2_uc002kcg.1_Missense_Mutation_p.N117H|PCYT2_uc002kch.1_Missense_Mutation_p.N106H|PCYT2_uc002kci.1_Missense_Mutation_p.N47H|PCYT2_uc010dii.1_Missense_Mutation_p.N106H|PCYT2_uc010wvc.1_Missense_Mutation_p.N28H	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	106	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			AAGTCACAGTTGTATTTGTCC	0.587													0	0	0	0.00632	0	20	44										G	79866776	T	G	79866776	3	3	121	1	0	0	0	0	1	0	0	0	11612	1812	63	5	955	5	PCYT2	17	79866776	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	1687447	79866776	1328434	447	36482										
TBCD	6904	broad.mit.edu	37	chr17	80772748	80772748	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgacaaggcgtggcatggggGatgtctggcgctggcagagc	19	8	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr17:80772748G>T	uc002kfz.2	+	13	1386	c.1256G>T	c.(1255-1257)GGA>GTA	p.G419V	TBCD_uc002kfx.1_Missense_Mutation_p.G402V|TBCD_uc002kfy.1_Missense_Mutation_p.G419V	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	419					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TGGCATGGGGGATGTCTGGCG	0.602													1	0	5.04308e-16	0.00623	5.62595e-16	28	16										T	80772748	G	T	80772748	3	4	121	1	0	0	0	0	1	0	0	0	15630	1174	41	3	1306	3	TBCD	17	80772748	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	905972	80772748	422462	448	36483										
SMCHD1	23347	broad.mit.edu	37	chr18	2688390	2688390	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgcattaatgttttattttAgtgatcattcaggatatgtt	7	4	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:2688390A>G	uc002klm.3	+	6	828	c.639_splice	c.e6-2	p.S213_splice		NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible						chromosome organization		ATP binding				0						GTTTTATTTTAGTGATCATTC	0.358													0	0	0	0.005524	0	30	32										G	2688390	A	G	2688390	5	3	121	1	0	0	0	0	0	0	1	0	14788	434	15	5	659	5	SMCHD1	18	2688390	Splice_Site	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08		2688390	75388858	449	36484										
KIAA0802	23255	broad.mit.edu	37	chr18	8784103	8784103	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtcctggtgccgggggtggGgcccccctgcaggaggagct	19	12	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:8784103G>T	uc002knr.2	+	6	1135	c.993G>T	c.(991-993)GGG>GGT	p.G331G	KIAA0802_uc002knq.2_Silent_p.G331G|KIAA0802_uc010dkw.1_Silent_p.G169G	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	682	Potential.										0						CCGGGGGTGGGGCCCCCCTGC	0.642													1	0	3.43241e-23	0.009718	3.93458e-23	36	31										T	8784103	G	T	8784103	2	4	121	1	0	0	0	0	0	0	0	1	8194	1219	43	4		4	KIAA0802	18	8784103	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6095713	8784103	69293145	450	36485										
POTEC	388468	broad.mit.edu	37	chr18	14542642	14542642	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tacctcttttgcttgtccctCttgttcatgtccgtgtccct	6	14	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:14542642C>G	uc010dln.2	-	1	958	c.504G>C	c.(502-504)AAG>AAC	p.K168N	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	168	ANK 1.									skin(3)	3						GCTTGTCCCTCTTGTTCATGT	0.597													0	0	0	0.00361	0	102	114										G	14542642	C	G	14542642	3	3	121	1	0	0	0	0	1	0	0	0	12262	912	32	1	1168	1	POTEC	18	14542642	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	5758539	14542642	63534606	451	36486										
SS18	6760	broad.mit.edu	37	chr18	23637560	23637560	+	Missense_Mutation	SNP	C	C	G													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagaaaaacttaccaggcatCtggccgttcatctggttctg							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:23637560C>G	uc002kvm.2	-	4	456	c.378G>C	c.(376-378)CAG>CAC	p.Q126H	SS18_uc002kvn.2_Missense_Mutation_p.Q126H|SS18_uc010xbf.1_Missense_Mutation_p.Q44H|SS18_uc010xbg.1_Missense_Mutation_p.Q74H|SS18_uc010xbh.1_Missense_Mutation_p.Q74H|SS18_uc010xbi.1_Missense_Mutation_p.Q103H|SS18_uc010dlz.1_Missense_Mutation_p.Q74H	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	126	Transcriptional activation.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TACCAGGCATCTGGCCGTTCA	0.522			T	SSX1| SSX2	synovial sarcoma								0	0	0	0.011902	0	34	46										G	23637560	C	G	23637560	3	3	121	1	0	0	0	0	1	0	0	0	15174	912	32	1	910	1	SS18	18	23637560	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9094918	23637560	54439688	452	36487	189	2								
SS18	6760	broad.mit.edu	37	chr18	23637569	23637569	+	Missense_Mutation	SNP	C	C	T													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttaccaggcatctggccgttCatctggttctgcatgtgcgg							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:23637569C>T	uc002kvm.2	-	4	447	c.369G>A	c.(367-369)ATG>ATA	p.M123I	SS18_uc002kvn.2_Missense_Mutation_p.M123I|SS18_uc010xbf.1_Missense_Mutation_p.M41I|SS18_uc010xbg.1_Missense_Mutation_p.M71I|SS18_uc010xbh.1_Missense_Mutation_p.M71I|SS18_uc010xbi.1_Missense_Mutation_p.M100I|SS18_uc010dlz.1_Missense_Mutation_p.M71I	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	123	Transcriptional activation.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					TCTGGCCGTTCATCTGGTTCT	0.522			T	SSX1| SSX2	synovial sarcoma								0	0	0	0.00361	0	39	49										T	23637569	C	T	23637569	3	4	121	1	0	0	0	0	1	0	0	0	15174	826	29	1	919	1	SS18	18	23637569	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9	23637569	54439679	453	36488	189	2								
DSG1	1828	broad.mit.edu	37	chr18	28926104	28926104	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acattaagaagaaattctatGagggaatgtagagaaggagg	13	2	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:28926104G>C	uc002kwp.2	+	14	2255	c.2043G>C	c.(2041-2043)ATG>ATC	p.M681I	DSG1_uc010xbp.1_Missense_Mutation_p.M40I	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	681	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GAAATTCTATGAGGGAATGTA	0.418													0	0	0	0.00361	0	40	44										C	28926104	G	C	28926104	3	2	121	1	0	0	0	0	1	0	0	0	4776	1290	45	1	2097	1	DSG1	18	28926104	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5288535	28926104	49151144	454	36489										
C18orf10	25941	broad.mit.edu	37	chr18	34378506	34378506	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggcggtaataggcagtaaagGtgtctgtgagaaaatgccag	15	5	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:34378506G>C	uc002kzw.1	-	6	991	c.563C>G	c.(562-564)ACC>AGC	p.T188S	C18orf10_uc002kzv.1_Missense_Mutation_p.T188S|C18orf10_uc010xci.1_Missense_Mutation_p.T153S|C18orf10_uc002kzx.1_Missense_Mutation_p.T145S|C18orf10_uc002kzy.3_Missense_Mutation_p.T188S	NM_015476	NP_056291	Q68CL5	TPGS2_HUMAN	tubulin polyglutamylase complex subunit 2	188						cytoplasm|microtubule				skin(1)	1						GGCAGTAAAGGTGTCTGTGAG	0.493													0	0	0	0.00361	0	62	62										C	34378506	G	C	34378506	3	2	121	1	0	0	0	0	1	0	0	0	1895	1261	44	4	347	4	C18orf10	18	34378506	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5452402	34378506	43698742	455	36490										
RNF165	494470	broad.mit.edu	37	chr18	44035973	44035973	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcaagggcaagaaggatgagGgggaggagtcagacacagat	18	5	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:44035973G>A	uc002lcb.1	+	7	904	c.853G>A	c.(853-855)GGG>AGG	p.G285R	RNF165_uc002lby.1_Missense_Mutation_p.G218R|RNF165_uc010dnn.1_Missense_Mutation_p.G81R	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	285							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		GAAGGATGAGGGGGAGGAGTC	0.507													0	0	0	0.00278	0	17	20										A	44035973	G	A	44035973	3	1	121	1	0	0	0	0	1	0	0	0	13456	1232	43	2	879	2	RNF165	18	44035973	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	9657467	44035973	34041275	456	36491										
SERPINB7	8710	broad.mit.edu	37	chr18	61465923	61465923	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctgtgtacttcaaaggcaaGtggcaatcagccttcaccaa	9	11	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:61465923G>C	uc002ljl.2	+	6	636	c.540G>C	c.(538-540)AAG>AAC	p.K180N	SERPINB7_uc002ljm.2_Missense_Mutation_p.K180N|SERPINB7_uc010xet.1_Missense_Mutation_p.K163N|SERPINB7_uc010dqg.2_Missense_Mutation_p.K180N	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	180					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				TCAAAGGCAAGTGGCAATCAG	0.393													0	0	0	0.010771	0	37	114										C	61465923	G	C	61465923	3	2	121	1	0	0	0	0	1	0	0	0	14106	1020	36	4	558	4	SERPINB7	18	61465923	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	17429950	61465923	16611325	457	36492										
RTTN	25914	broad.mit.edu	37	chr18	67788894	67788894	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaatgtatgatatctattagCagtttctcatcttcagtgca	6	7	4	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:67788894C>T	uc002lkp.2	-	26	3494	c.3426G>A	c.(3424-3426)CTG>CTA	p.L1142L	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.L230L	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1142							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TATCTATTAGCAGTTTCTCAT	0.308													0	0	0	0.004672	0	3	1										T	67788894	C	T	67788894	2	4	121	1	0	0	0	0	0	0	0	1	13737	697	25	2		2	RTTN	18	67788894	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6322971	67788894	10288354	458	36493										
TSHZ1	10194	broad.mit.edu	37	chr18	72999303	72999303	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagctggtggagaaggtcacGggcaaggtcaacatcaagaa	15	7	3	2	rs141313878	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:72999303G>A	uc002lly.2	+	2	2369	c.1806G>A	c.(1804-1806)ACG>ACA	p.T602T		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	647						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AGAAGGTCACGGGCAAGGTCA	0.602													0	0	0	0.003954	0	22	18										A	72999303	G	A	72999303	2	1	121	1	0	0	0	0	0	0	0	1	16620	1103	39	2		2	TSHZ1	18	72999303	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5210409	72999303	5077945	459	36494										
ZNF236	7776	broad.mit.edu	37	chr18	74580691	74580691	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tttactctgcagagtcagctGgccgtgcacatggaggagca	13	10	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:74580691G>A	uc002lmi.2	+	4	606	c.408G>A	c.(406-408)CTG>CTA	p.L136L	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Silent_p.L136L	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	136	C2H2-type 4.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AGAGTCAGCTGGCCGTGCACA	0.557													0	0	0	0.00361	0	78	72										A	74580691	G	A	74580691	2	1	121	1	0	0	0	0	0	0	0	1	17786	1335	47	2		2	ZNF236	18	74580691	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1581388	74580691	3496557	460	36495										
MBP	4155	broad.mit.edu	37	chr18	74700837	74700837	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cattccaaggtcttacctttCcctgcgacgggggtggtgtg	13	11	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr18:74700837C>T	uc010xfd.1	-	6	977	c.713G>A	c.(712-714)GGA>GAA	p.G238E	MBP_uc002lml.2_Missense_Mutation_p.G131E|MBP_uc002lmn.2_Missense_Mutation_p.G131E|MBP_uc002lmp.2_Missense_Mutation_p.G105E|MBP_uc010xfe.1_Missense_Mutation_p.G105E|MBP_uc010dqz.2_5'Flank	NM_001025101	NP_001020272	P02686	MBP_HUMAN	Golli-mbp isoform 1	238					central nervous system development|immune response|synaptic transmission	plasma membrane	structural constituent of myelin sheath			haematopoietic_and_lymphoid_tissue(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.79e-06)|BRCA - Breast invasive adenocarcinoma(31;0.113)|READ - Rectum adenocarcinoma(1;0.188)		TCTTACCTTTCCCTGCGACGG	0.522													0	0	0	0.00361	0	82	104										T	74700837	C	T	74700837	3	4	121	1	0	0	0	0	1	0	0	0	9359	855	30	1	217	1	MBP	18	74700837	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	120146	74700837	3376411	461	36496										
PRSSL1	400668	broad.mit.edu	37	chr19	691938	691938	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcatcgatgccaaacacctGctgggtgggctccgcagtac	12	13	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:691938G>T	uc002lpl.1	-	3	332	c.301C>A	c.(301-303)CAG>AAG	p.Q101K	PRSSL1_uc010xfs.1_Missense_Mutation_p.Q100K	NM_214710	NP_999875	Q6UWY2	PRS57_HUMAN	protease, serine-like 1 precursor	101	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAAACACCTGCTGGGTGGGC	0.672													1	0	6.94344e-10	0.006122	7.41079e-10	16	23										T	691938	G	T	691938	3	4	121	1	0	0	0	0	1	0	0	0	12636	1328	46	4	562	4	PRSSL1	19	691938	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		691938	58437045	462	36497										
DOT1L	84444	broad.mit.edu	37	chr19	2216762	2216762	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctgccagtgagctgcattcGaggtgagtgccctggtgggg	18	9	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:2216762G>A	uc002lvb.3	+	20	2442	c.2406G>A	c.(2404-2406)TCG>TCA	p.S802S	DOT1L_uc002lvc.1_Silent_p.S96S|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Silent_p.S96S	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	802						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGCATTCGAGGTGAGTGC	0.652													0	0	0	0.008361	0	23	96										A	2216762	G	A	2216762	2	1	121	1	0	0	0	0	0	0	0	1	4709	1045	37	1		1	DOT1L	19	2216762	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1524824	2216762	56912221	463	36498										
CREB3L3	84699	broad.mit.edu	37	chr19	4168393	4168393	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccgccggaaaatccggaacAagcagtcggcgcaagaaagc	12	12	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:4168393A>G	uc002lzl.2	+	6	876	c.760A>G	c.(760-762)AAG>GAG	p.K254E	CREB3L3_uc002lzm.2_Missense_Mutation_p.K244E|CREB3L3_uc010xib.1_Missense_Mutation_p.K243E|CREB3L3_uc010xic.1_Intron	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	254	Basic motif.|Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		AATCCGGAACAAGCAGTCGGC	0.413													0	0	0	0.010504	0	19	16										G	4168393	A	G	4168393	3	3	121	1	0	0	0	0	1	0	0	0	3858	131	5	5	782	5	CREB3L3	19	4168393	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1951631	4168393	54960590	464	36499										
SH3GL1	6455	broad.mit.edu	37	chr19	4361711	4361711	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggttggtcagcgtgatgacGtcgccctcatggaagcccag	14	11	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:4361711G>A	uc002maj.2	-	10	1099	c.993C>T	c.(991-993)GAC>GAT	p.D331D	SH3GL1_uc002mak.2_Silent_p.D267D|SH3GL1_uc010xig.1_Silent_p.D283D	NM_003025	NP_003016	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	331	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		GCGTGATGACGTCGCCCTCAT	0.662			T	MLL	AL								0	0	0	0.008291	0	6	120										A	4361711	G	A	4361711	2	1	121	1	0	0	0	0	0	0	0	1	14250	1136	40	2		2	SH3GL1	19	4361711	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	193318	4361711	54767272	465	36500										
PLIN4	729359	broad.mit.edu	37	chr19	4504533	4504533	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctgagcgggggattgtgctGtaggccctccagcagctgct	16	11	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:4504533G>A	uc002mar.1	-	6	4012	c.4012C>T	c.(4012-4014)CAG>TAG	p.Q1338*	PLIN4_uc010dub.1_Nonsense_Mutation_p.Q362*	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1338						lipid particle|plasma membrane					0						GGATTGTGCTGTAGGCCCTCC	0.701													0	0	0	0.010818	0	22	5										A	4504533	G	A	4504533	4	1	121	1	0	0	0	0	0	1	0	0	12092	1386	48	2	65	2	PLIN4	19	4504533	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	142822	4504533	54624450	466	36501										
DENND1C	79958	broad.mit.edu	37	chr19	6479898	6479898	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgaagtctggagggaactgcCgcaggatggggggatctgta	18	6	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:6479898C>A	uc002mfe.2	-	3	190	c.98G>T	c.(97-99)CGG>CTG	p.R33L	DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Intron	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	33	UDENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						AGGGAACTGCCGCAGGATGGG	0.642													1	0	0.00448238	0.004482	0.00456463	6	4										A	6479898	C	A	6479898	3	1	121	1	0	0	0	0	1	0	0	0	4428	652	23	4	2391	4	DENND1C	19	6479898	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1975365	6479898	52649085	467	36502										
TUBB4	10382	broad.mit.edu	37	chr19	6501571	6501571	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gatcctctccagttgcaggtCactgtccccatggtatgtgc	10	13	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:6501571C>T	uc002mfg.1	-	2	228	c.121G>A	c.(121-123)GAC>AAC	p.D41N	TUBB4_uc002mff.1_5'UTR	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	41					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		AGTTGCAGGTCACTGTCCCCA	0.572													0	0	0	0.00361	0	127	36										T	6501571	C	T	6501571	3	4	121	1	0	0	0	0	1	0	0	0	16755	826	29	1	1225	1	TUBB4	19	6501571	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	21673	6501571	52627412	468	36503										
ARHGEF18	23370	broad.mit.edu	37	chr19	7518383	7518383	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggactatgaagacctgacccAggccttgaacctcatcaaag	9	12	2	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:7518383A>T	uc002mgi.2	+	7	1575	c.1322A>T	c.(1321-1323)CAG>CTG	p.Q441L	ARHGEF18_uc010xjm.1_Missense_Mutation_p.Q283L|ARHGEF18_uc002mgh.2_Missense_Mutation_p.Q283L|ARHGEF18_uc002mgj.1_Missense_Mutation_p.Q84L	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	441	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GACCTGACCCAGGCCTTGAAC	0.507													0	0	0	0.004656	0	21	88										T	7518383	A	T	7518383	3	4	121	1	0	0	0	0	1	0	0	0	901	188	7	5	1348	5	ARHGEF18	19	7518383	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1016812	7518383	51610600	469	36504										
FBN3	84467	broad.mit.edu	37	chr19	8182137	8182137	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcagtgttaatacagtgcaCgtcacacccaccattctgga	7	13	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:8182137C>T	uc002mjf.2	-	27	3523	c.3502G>A	c.(3502-3504)GTG>ATG	p.V1168M		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1168	EGF-like 16; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						ATACAGTGCACGTCACACCCA	0.473													0	0	0	0.009718	0	31	148										T	8182137	C	T	8182137	3	4	121	1	0	0	0	0	1	0	0	0	5704	536	19	2	5075	2	FBN3	19	8182137	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	663754	8182137	50946846	470	36505										
ZNF558	148156	broad.mit.edu	37	chr19	8922561	8922561	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catagggtttctccccattaTggattctcttatgaatagta	7	8	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:8922561T>G	uc002mkn.1	-	6	835	c.605A>C	c.(604-606)CAT>CCT	p.H202P	ZNF558_uc010xkh.1_Missense_Mutation_p.H131P|ZNF558_uc010dwg.1_Missense_Mutation_p.H202P	NM_144693	NP_653294	Q96NG5	ZN558_HUMAN	zinc finger protein 558	202	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CTCCCCATTATGGATTCTCTT	0.413													0	0	0	0.006122	0	14	63										G	8922561	T	G	8922561	3	3	121	1	0	0	0	0	1	0	0	0	17986	1464	51	5	607	5	ZNF558	19	8922561	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	740424	8922561	50206422	471	36506										
MUC16	94025	broad.mit.edu	37	chr19	8969284	8969284	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccccttctcaccgcatcctCaatattccttttgttcctct	2	18	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:8969284C>G	uc002mkp.2	-	79	43264	c.43060G>C	c.(43060-43062)GAG>CAG	p.E14354Q	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.E1154Q|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACCGCATCCTCAATATTCCTT	0.463													0	0	0	0.00361	0	46	222										G	8969284	C	G	8969284	3	3	121	1	0	0	0	0	1	0	0	0	9973	835	29	1	487	1	MUC16	19	8969284	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	46723	8969284	50159699	472	36507										
MUC16	94025	broad.mit.edu	37	chr19	9058783	9058783	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggaaaccatgttgtctcttaTagaggaagaggtgaccactg	12	7	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:9058783T>C	uc002mkp.2	-	3	28867	c.28663A>G	c.(28663-28665)ATA>GTA	p.I9555V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9557	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGTCTCTTATAGAGGAAGAG	0.488													0	0	0	0.00361	0	39	8										C	9058783	T	C	9058783	3	2	121	1	0	0	0	0	1	0	0	0	9973	1406	49	5	15188	5	MUC16	19	9058783	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	89499	9058783	50070200	473	36508										
MUC16	94025	broad.mit.edu	37	chr19	9065491	9065491	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggtcatttctgatgattctgCcaggatgggggaagtaggga	16	5	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:9065491C>G	uc002mkp.2	-	3	22159	c.21955G>C	c.(21955-21957)GCA>CCA	p.A7319P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7321	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGATTCTGCCAGGATGGGG	0.453													0	0	0	0.002836	0	30	10										G	9065491	C	G	9065491	3	3	121	1	0	0	0	0	1	0	0	0	9973	739	26	4	21896	4	MUC16	19	9065491	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6708	9065491	50063492	474	36509										
MUC16	94025	broad.mit.edu	37	chr19	9086871	9086871	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gatgttcctatgggaaggtgGgctatgcccagggtgactcc	15	9	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:9086871G>T	uc002mkp.2	-	1	5148	c.4944C>A	c.(4942-4944)GCC>GCA	p.A1648A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1648	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGAAGGTGGGCTATGCCCA	0.517													1	0	3.47496e-60	0.00361	4.12536e-60	118	34										T	9086871	G	T	9086871	2	4	121	1	0	0	0	0	0	0	0	1	9973	1219	43	4		4	MUC16	19	9086871	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	21380	9086871	50042112	475	36510										
COL5A3	50509	broad.mit.edu	37	chr19	10084485	10084485	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccaggcagccctggagtgcCctggagagacagcaaggggt	16	11	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:10084485C>T	uc002mmq.1	-	49	3645	c.3559G>A	c.(3559-3561)GGC>AGC	p.G1187S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1187	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCTGGAGTGCCCTGGAGAGAC	0.592													0	0	0	0.00361	0	93	39										T	10084485	C	T	10084485	3	4	121	1	0	0	0	0	1	0	0	0	3698	637	22	2	1754	2	COL5A3	19	10084485	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	997614	10084485	49044498	476	36511										
COL5A3	50509	broad.mit.edu	37	chr19	10116261	10116261	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtcttttccccaaggtcctgGgtccccagcacagtgagtcc	10	15	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:10116261G>A	uc002mmq.1	-	4	653	c.567C>T	c.(565-567)ACC>ACT	p.T189T		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	189	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CAAGGTCCTGGGTCCCCAGCA	0.562													0	0	0	0.001168	0	3	71										A	10116261	G	A	10116261	2	1	121	1	0	0	0	0	0	0	0	1	3698	1219	43	2		2	COL5A3	19	10116261	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	31776	10116261	49012722	477	36512										
PPAN-P2RY11	692312	broad.mit.edu	37	chr19	10225253	10225253	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtgtccaccctctactctacAtggccgcagtgcccagcctg	9	17	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:10225253A>G	uc002mna.2	+	13	2224	c.2224A>G	c.(2224-2226)ATG>GTG	p.M742V	PPAN-P2RY11_uc010xla.1_3'UTR|P2RY11_uc002mnc.2_Missense_Mutation_p.M322V	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TCTACTCTACATGGCCGCAGT	0.682													0	0	0	0.004656	0	21	89										G	10225253	A	G	10225253	3	3	121	1	0	0	0	0	1	0	0	0	12289	217	8	5		5	PPAN-P2RY11	19	10225253	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	108992	10225253	48903730	478	36513										
PRKCSH	5589	broad.mit.edu	37	chr19	11558507	11558507	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgaccctgcccctgccccaGgaggccccaccgccactgtc	9	22	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:11558507G>A	uc002mrt.2	+	12	1345	c.1009_splice	c.e12-1	p.E337_splice	PRKCSH_uc002mru.2_Intron|PRKCSH_uc010xlz.1_Splice_Site_p.E344_splice|PRKCSH_uc010dya.2_Splice_Site_p.E119_splice|PRKCSH_uc010dyb.2_Intron	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1						innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						CCCTGCCCCAGGAGGCCCCAC	0.667													0	0	0	0.006214	0	7	4										A	11558507	G	A	11558507	5	1	121	1	0	0	0	0	0	0	1	0	12516	1014	35	2	1071	2	PRKCSH	19	11558507	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1333254	11558507	47570476	479	36514										
ZNF878	729747	broad.mit.edu	37	chr19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctacgaacagaactgggaaaActgaatgctttcccacactg	8	11	0	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:12155673A>C	uc002mta.1	-	5	684	c.684T>G	c.(682-684)AGT>AGG	p.S228R		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	181	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AACTGGGAAAACTGAATGCTT	0.403													0	0	0	0.00308	0	8	179										C	12155673	A	C	12155673	3	2	121	1	0	0	0	0	1	0	0	0	18193	40	2	5	1056	5	ZNF878	19	12155673	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	597166	12155673	46973310	480	36515										
MAST1	22983	broad.mit.edu	37	chr19	12984213	12984213	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	actagccgctcgctgtcgtcGctgaaccgctcgctgtcatc	10	16	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:12984213G>T	uc002mvm.2	+	25	3467	c.3339G>T	c.(3337-3339)TCG>TCT	p.S1113S		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	1113					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CGCTGTCGTCGCTGAACCGCT	0.667													1	0	1.55795e-14	0.012319	1.72072e-14	17	14										T	12984213	G	T	12984213	2	4	121	1	0	0	0	0	0	0	0	1	9324	1074	38	4		4	MAST1	19	12984213	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	828540	12984213	46144770	481	36516										
FARSA	2193	broad.mit.edu	37	chr19	13039382	13039382	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agatctgtcggaactgggagCggaccttgagcagcgggtga	17	8	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:13039382C>A	uc002mvs.2	-	6	740	c.692G>T	c.(691-693)CGC>CTC	p.R231L	FARSA_uc002mvt.2_Intron|FARSA_uc010xmv.1_Missense_Mutation_p.R200L|FARSA_uc010dyy.1_Missense_Mutation_p.R152L	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	231					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	GAACTGGGAGCGGACCTTGAG	0.657													1	0	5.60225e-13	0.009535	6.1266e-13	25	13										A	13039382	C	A	13039382	3	1	121	1	0	0	0	0	1	0	0	0	5679	768	27	4	866	4	FARSA	19	13039382	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	55169	13039382	46089601	482	36517										
NFIX	4784	broad.mit.edu	37	chr19	13201190	13201190	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acggcaactttctgaacatcCcacagcagtctcaggtagga	9	12	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:13201190C>A	uc010xmx.1	+	10	1557	c.1504C>A	c.(1504-1506)CCA>ACA	p.P502T	NFIX_uc002mwd.2_3'UTR|NFIX_uc002mwe.2_3'UTR|NFIX_uc002mwf.2_3'UTR|NFIX_uc002mwg.1_3'UTR			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	494					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			TCTGAACATCCCACAGCAGTC	0.622													1	0	2.21704e-12	0.00278	2.41266e-12	17	59										A	13201190	C	A	13201190	3	1	121	1	0	0	0	0	1	0	0	0	10374	638	22	4		4	NFIX	19	13201190	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	161808	13201190	45927793	483	36518										
CACNA1A	773	broad.mit.edu	37	chr19	13325352	13325352	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcaggtctagcgtcttctgGgacagattgggccaaatcgc	13	10	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:13325352G>T	uc010dze.2	-	39	6041	c.5805C>A	c.(5803-5805)TCC>TCA	p.S1935S	CACNA1A_uc010xnd.1_Silent_p.S640S|CACNA1A_uc002mwx.3_Silent_p.S640S|CACNA1A_uc010dzc.2_Silent_p.S1460S|CACNA1A_uc002mwy.3_Silent_p.S1934S|CACNA1A_uc002mwv.3_Silent_p.S451S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1935	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCGTCTTCTGGGACAGATTGG	0.582													1	0	7.41945e-09	0.005443	7.8186e-09	19	13										T	13325352	G	T	13325352	2	4	121	1	0	0	0	0	0	0	0	1	2538	1219	43	4		4	CACNA1A	19	13325352	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	124162	13325352	45803631	484	36519										
LPHN1	22859	broad.mit.edu	37	chr19	14263685	14263685	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gggtggggagcggatgcagcAgtaggagtgacgcaggcact	20	7	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:14263685A>T	uc010xnn.1	-	20	3645	c.3349T>A	c.(3349-3351)TGC>AGC	p.C1117S	LPHN1_uc010xno.1_Missense_Mutation_p.C1112S|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	1117	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						CGGATGCAGCAGTAGGAGTGA	0.627													0	0	0	0.00361	0	41	109										T	14263685	A	T	14263685	3	4	121	1	0	0	0	0	1	0	0	0	8915	188	7	5	1095	5	LPHN1	19	14263685	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	938333	14263685	44865298	485	36520										
TECR	9524	broad.mit.edu	37	chr19	14640523	14640523	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ggagccatgaagcattacgaGgtaagaagcgagaaacaggg	15	6	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:14640523G>A	uc002mza.2	+	1	142	c.15G>A	c.(13-15)GAG>GAA	p.E5E	DNAJB1_uc010xnr.1_5'Flank|TECR_uc002mzb.2_5'UTR|TECR_uc010xns.1_5'UTR|TECR_uc002mzc.2_5'UTR|TECR_uc002mzd.2_Silent_p.E5E	NM_138501	NP_612510	Q9NZ01	TECR_HUMAN	glycoprotein, synaptic 2	5					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity				0						AGCATTACGAGGTAAGAAGCG	0.622													0	0	0	0.004482	0	5	36										A	14640523	G	A	14640523	2	1	121	1	0	0	0	0	0	0	0	1	15742	1014	35	2		2	TECR	19	14640523	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	376838	14640523	44488460	486	36521										
MYO9B	4650	broad.mit.edu	37	chr19	17312810	17312810	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgagaagttcaggagcaacAtcaaaacgatgtactctgtc	9	10	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:17312810A>T	uc010eak.2	+	27	4791	c.4639A>T	c.(4639-4641)ATC>TTC	p.I1547F	MYO9B_uc002nfi.2_Missense_Mutation_p.I1547F|MYO9B_uc002nfj.1_Missense_Mutation_p.I1547F|MYO9B_uc002nfl.1_Missense_Mutation_p.I96F	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1547	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CAGGAGCAACATCAAAACGAT	0.567													0	0	0	0.003163	0	11	7										T	17312810	A	T	17312810	3	4	121	1	0	0	0	0	1	0	0	0	10085	217	8	5	4741	5	MYO9B	19	17312810	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2672287	17312810	41816173	487	36522										
ATP13A1	57130	broad.mit.edu	37	chr19	19756542	19756542	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatgatggccaggagtgaaaCtgccagactccacaccaggg	12	11	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:19756542C>G	uc002nnh.3	-	25	3446	c.3418G>C	c.(3418-3420)GTT>CTT	p.V1140L	GMIP_uc002nnd.2_5'Flank|GMIP_uc010xrb.1_5'Flank|GMIP_uc010xrc.1_5'Flank|ATP13A1_uc002nne.2_Missense_Mutation_p.V280L|ATP13A1_uc002nnf.3_Missense_Mutation_p.V508L|ATP13A1_uc002nng.2_Missense_Mutation_p.V1022L	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	1140	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						AGGAGTGAAACTGCCAGACTC	0.637													0	0	0	0.004672	0	2	2										G	19756542	C	G	19756542	3	3	121	1	0	0	0	0	1	0	0	0	1123	565	20	4	204	4	ATP13A1	19	19756542	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2443732	19756542	39372441	488	36523										
ZNF507	22847	broad.mit.edu	37	chr19	32845599	32845599	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gcccagtgccaacccaacagCgatacaagtttgtccggaaa	9	13	0	0	rs139741881	by1000genomes	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:32845599C>G	uc002nte.2	+	3	2135	c.1863C>G	c.(1861-1863)AGC>AGG	p.S621R	ZNF507_uc002ntc.2_Missense_Mutation_p.S621R|ZNF507_uc010xrn.1_Missense_Mutation_p.S621R|ZNF507_uc002ntd.2_Missense_Mutation_p.S621R	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	621					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					AACCCAACAGCGATACAAGTT	0.488													0	0	0	0.004007	0	12	165										G	32845599	C	G	32845599	3	3	121	1	0	0	0	0	1	0	0	0	17950	767	27	4	1865	4	ZNF507	19	32845599	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	13089057	32845599	26283384	489	36524										
ZFP14	57677	broad.mit.edu	37	chr19	36831467	36831467	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttcacattcatagggtctctCaccaatatgaatgctctggt	7	10	5	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:36831467C>T	uc002odx.1	-	4	1354	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K	ZFP14_uc010xtd.1_Missense_Mutation_p.E422K|ZFP14_uc010eex.1_Missense_Mutation_p.E421K	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					TAGGGTCTCTCACCAATATGA	0.403													0	0	0	0.009535	0	27	105										T	36831467	C	T	36831467	3	4	121	1	0	0	0	0	1	0	0	0	17636	835	29	1	344	1	ZFP14	19	36831467	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3985868	36831467	22297516	490	36525										
ZNF260	339324	broad.mit.edu	37	chr19	37005871	37005871	+	Frame_Shift_Del	DEL	T	T	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttttccttctggctgaaggcTtttccacatttattacattt							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:37005871delT	uc002oee.1	-	4	1114	c.270delA	c.(268-270)AAAfs	p.K90fs	ZNF260_uc002oed.1_Frame_Shift_Del_p.K87fs|ZNF260_uc010eey.1_Frame_Shift_Del_p.K87fs|ZNF260_uc002oef.1_Frame_Shift_Del_p.K87fs	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	90	C2H2-type 3.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					GGCTGAAGGCTTTTCCACATT	0.393																		34	7	---	---								-	37005871	T	-	37005871	7	5	121	1	0	1	0	1	0	0	0	0	17799	1606	56	0	972	0	ZNF260	19	37005871	Frame_Shift_Del	DEL	T	TCGA-GV-A3QI-01A-11D-A21Z-08	174404	37005871	22123112	491	36526										
FCGBP	8857	broad.mit.edu	37	chr19	40354440	40354440	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agccacacctggacccctgcCttctggcggactagcaggga	12	15	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:40354440C>T	uc002omp.3	-	35	16037	c.16029G>A	c.(16027-16029)AAG>AAA	p.K5343K		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5343	VWFD 13.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGACCCCTGCCTTCTGGCGGA	0.572													0	0	0	0.004656	0	19	1										T	40354440	C	T	40354440	2	4	121	1	0	0	0	0	0	0	0	1	5778	680	24	2		2	FCGBP	19	40354440	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3348569	40354440	18774543	492	36527										
LTBP4	8425	broad.mit.edu	37	chr19	41115484	41115484	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cccccaggtctgcggcccagGacgctgcatttcccggccca	11	19	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:41115484G>A	uc002ooh.1	+	13	1676	c.1676G>A	c.(1675-1677)GGA>GAA	p.G559E	LTBP4_uc002oog.1_Missense_Mutation_p.G522E|LTBP4_uc002ooi.1_Missense_Mutation_p.G492E|LTBP4_uc002ooj.1_5'Flank|LTBP4_uc010xvo.1_5'Flank|LTBP4_uc010ehb.1_5'Flank|LTBP4_uc002ook.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	559	Pro-rich.|EGF-like 3.|Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGCGGCCCAGGACGCTGCATT	0.667													0	0	0	0.00361	0	48	2										A	41115484	G	A	41115484	3	1	121	1	0	0	0	0	1	0	0	0	9076	1174	41	1	2019	1	LTBP4	19	41115484	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	761044	41115484	18013499	493	36528										
CEACAM21	90273	broad.mit.edu	37	chr19	42092192	42092192	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cacttttgtctctgtccccaGgccatggaccctctgacagc	8	16	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:42092192G>A	uc002ore.3	+	6	947	c.851_splice	c.e6-1	p.G284_splice	CEACAM21_uc002orc.1_Splice_Site|CEACAM21_uc002ord.1_Intron|CEACAM21_uc002orf.2_Splice_Site|CEACAM21_uc002org.3_Splice_Site_p.G283_splice	NM_001098506	NP_001091976	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion							integral to membrane				ovary(1)	1						TCTGTCCCCAGGCCATGGACC	0.587													0	0	0	0.010504	0	15	1										A	42092192	G	A	42092192	5	1	121	1	0	0	0	0	0	0	1	0	3192	1014	35	2	872	2	CEACAM21	19	42092192	Splice_Site	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	976708	42092192	17036791	494	36529										
PRKD2	25865	broad.mit.edu	37	chr19	47178362	47178362	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttcacctgcagcaggttgttGatgaggtcaatggctgcaca	12	9	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:47178362G>C	uc002pfh.2	-	18	2694	c.2352C>G	c.(2350-2352)ATC>ATG	p.I784M	PRKD2_uc002pfd.2_Missense_Mutation_p.I158M|PRKD2_uc010eks.2_Missense_Mutation_p.I187M|PRKD2_uc010ekt.2_Missense_Mutation_p.I51M|PRKD2_uc002pfe.2_Missense_Mutation_p.I314M|PRKD2_uc002pff.2_Missense_Mutation_p.I304M|PRKD2_uc002pfg.2_Missense_Mutation_p.I627M|PRKD2_uc002pfi.2_Missense_Mutation_p.I784M|PRKD2_uc002pfj.2_Missense_Mutation_p.I784M|PRKD2_uc010xye.1_Missense_Mutation_p.I794M|PRKD2_uc002pfk.2_Missense_Mutation_p.I627M	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	784	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GCAGGTTGTTGATGAGGTCAA	0.572													0	0	0	0.003163	0	13	0										C	47178362	G	C	47178362	3	2	121	1	0	0	0	0	1	0	0	0	12519	1280	45	1	292	1	PRKD2	19	47178362	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	5086170	47178362	11950621	495	36530										
IL4I1	259307	broad.mit.edu	37	chr19	50393824	50393824	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagctcagcagcgcgcgcggCagcaggtcccagccacccac	13	18	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:50393824C>A	uc002pqt.1	-	8	885	c.807G>T	c.(805-807)CTG>CTT	p.L269L	IL4I1_uc002pqv.1_Silent_p.L278L|IL4I1_uc010eno.1_Silent_p.L277L|IL4I1_uc002pqw.1_Silent_p.L277L|IL4I1_uc002pqu.1_Silent_p.L291L	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	269						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		GCGCGCGCGGCAGCAGGTCCC	0.721													1	0	9.95505e-16	0.002299	1.10686e-15	14	1										A	50393824	C	A	50393824	2	1	121	1	0	0	0	0	0	0	0	1	7697	697	25	4		4	IL4I1	19	50393824	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3215462	50393824	8735159	496	36531										
SYT3	84258	broad.mit.edu	37	chr19	51140567	51140567	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cggattcggtcattgaactcCtggcacctgtcgttggtgtc	12	11	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:51140567C>T	uc002pst.2	-	1	736	c.102G>A	c.(100-102)CAG>CAA	p.Q34Q	SYT3_uc002psv.2_Silent_p.Q34Q|SYT3_uc010ycd.1_Silent_p.Q34Q	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	34	Vesicular (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CATTGAACTCCTGGCACCTGT	0.627													0	0	0	0.00361	0	130	3										T	51140567	C	T	51140567	2	4	121	1	0	0	0	0	0	0	0	1	15472	680	24	2		2	SYT3	19	51140567	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	746743	51140567	7988416	497	36532										
SHANK1	50944	broad.mit.edu	37	chr19	51205873	51205873	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcccccggggccccctgagCcccccgtgcccccggctggc	13	23	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:51205873C>T	uc002psx.1	-	11	1617	c.1598G>A	c.(1597-1599)GGC>GAC	p.G533D		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	533					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GCCCCCTGAGCCCCCCGTGCC	0.716													0	0	0	0.004482	0	6	0										T	51205873	C	T	51205873	3	4	121	1	0	0	0	0	1	0	0	0	14264	739	26	2	4939	2	SHANK1	19	51205873	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	65306	51205873	7923110	498	36533										
ACPT	93650	broad.mit.edu	37	chr19	51298162	51298162	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctaccagctgactgccccggCccggcctcccgcccatgggg	12	20	0	1	rs140557537	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:51298162C>T	uc002pta.1	+	10	1106	c.1106C>T	c.(1105-1107)GCC>GTC	p.A369V		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	369	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		ACTGCCCCGGCCCGGCCTCCC	0.692													0	0	0	0.00361	0	241	3										T	51298162	C	T	51298162	3	4	121	1	0	0	0	0	1	0	0	0	168	739	26	2	1144	2	ACPT	19	51298162	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	92289	51298162	7830821	499	36534										
ZNF528	84436	broad.mit.edu	37	chr19	52918824	52918824	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatgcatactggagagaagcCttacaaatgtcatgaatgtg	10	6	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:52918824C>T	uc002pzh.2	+	7	1145	c.719C>T	c.(718-720)CCT>CTT	p.P240L	ZNF528_uc002pzi.2_Missense_Mutation_p.P7L	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GGAGAGAAGCCTTACAAATGT	0.388													0	0	0	0.010729	0	9	55										T	52918824	C	T	52918824	3	4	121	1	0	0	0	0	1	0	0	0	17966	681	24	2	733	2	ZNF528	19	52918824	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1620662	52918824	6210159	500	36535										
ZNF578	147660	broad.mit.edu	37	chr19	53014565	53014565	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gccatcgtagatgtcacactGgtgagaaaccttacaagtgt	10	9	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:53014565G>A	uc002pzp.3	+	6	1175	c.931G>A	c.(931-933)GGT>AGT	p.G311S		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATGTCACACTGGTGAGAAACC	0.418													0	0	0	0.004672	0	3	126										A	53014565	G	A	53014565	3	1	121	1	0	0	0	0	1	0	0	0	18007	1348	47	2	941	2	ZNF578	19	53014565	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	95741	53014565	6114418	501	36536										
ZNF578	147660	broad.mit.edu	37	chr19	53014626	53014626	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagttacaagtcatcccttaCatgccatcataggtgtcaca	6	12	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:53014626C>G	uc002pzp.3	+	6	1236	c.992C>G	c.(991-993)ACA>AGA	p.T331R		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	106	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TCATCCCTTACATGCCATCAT	0.423													0	0	0	0.009096	0	3	132										G	53014626	C	G	53014626	3	3	121	1	0	0	0	0	1	0	0	0	18007	478	17	4	1002	4	ZNF578	19	53014626	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	61	53014626	6114357	502	36537										
ZNF808	388558	broad.mit.edu	37	chr19	53057047	53057047	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttacaagtgtaaagagtgtgGaaagtccttcagttacaagt	10	5	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:53057047G>C	uc010epq.1	+	5	1055	c.878G>C	c.(877-879)GGA>GCA	p.G293A	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	293	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		AAAGAGTGTGGAAAGTCCTTC	0.408													0	0	0	0.001168	0	4	180										C	53057047	G	C	53057047	3	2	121	1	0	0	0	0	1	0	0	0	18170	1174	41	1	888	1	ZNF808	19	53057047	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	42421	53057047	6071936	503	36538										
VN1R4	317703	broad.mit.edu	37	chr19	53770252	53770252	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gttctctggggaggctctggGggagagattgctcctatcaa	15	8	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:53770252G>T	uc010ydu.1	-	1	667	c.667C>A	c.(667-669)CCC>ACC	p.P223T		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	223	Cytoplasmic (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		GAGGCTCTGGGGGAGAGATTG	0.537										HNSCC(26;0.072)			1	0	7.92952e-12	0.003954	8.58709e-12	21	2										T	53770252	G	T	53770252	3	4	121	1	0	0	0	0	1	0	0	0	17177	1232	43	4	241	4	VN1R4	19	53770252	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	713205	53770252	5358731	504	36539										
LILRA4	23547	broad.mit.edu	37	chr19	54848849	54848849	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgggggaggccatcggccccCtccttgtacagagtgtatct	13	12	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:54848849C>T	uc002qfj.2	-	5	831	c.774G>A	c.(772-774)GAG>GAA	p.E258E	LILRA4_uc002qfi.2_Silent_p.E192E	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	258	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CATCGGCCCCCTCCTTGTACA	0.677													0	0	0	0.00623	0	34	1										T	54848849	C	T	54848849	2	4	121	1	0	0	0	0	0	0	0	1	8787	680	24	2		2	LILRA4	19	54848849	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1078597	54848849	4280134	505	36540										
PTPRH	5794	broad.mit.edu	37	chr19	55718252	55718252	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgtgagtctaggccatcggGgacctcccagctcagggaga	14	12	2	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:55718252G>T	uc002qjq.2	-	3	230	c.157C>A	c.(157-159)CCC>ACC	p.P53T	PTPRH_uc010esv.2_Missense_Mutation_p.P53T|PTPRH_uc002qjs.2_Missense_Mutation_p.P60T	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	53	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGGCCATCGGGGACCTCCCAG	0.567													1	0	5.12918e-33	0.00361	6.02475e-33	53	2										T	55718252	G	T	55718252	3	4	121	1	0	0	0	0	1	0	0	0	12803	1232	43	4	3262	4	PTPRH	19	55718252	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	869403	55718252	3410731	506	36541										
ZNF776	284309	broad.mit.edu	37	chr19	58265844	58265844	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcaaaagggcagtctcattcAacatcagcagatccactctg	7	12	5	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:58265844A>G	uc002qpx.2	+	3	1569	c.1346A>G	c.(1345-1347)CAA>CGA	p.Q449R	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.Q449R	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	449	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		AGTCTCATTCAACATCAGCAG	0.448													0	0	0	0.000602	0	4	133										G	58265844	A	G	58265844	3	3	121	1	0	0	0	0	1	0	0	0	18146	130	5	5	1356	5	ZNF776	19	58265844	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	2547592	58265844	863139	507	36542										
ZNF776	284309	broad.mit.edu	37	chr19	58265857	58265857	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcattcaacatcagcagatCcactctggagaaaggccaca	7	13	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr19:58265857C>T	uc002qpx.2	+	3	1582	c.1359C>T	c.(1357-1359)ATC>ATT	p.I453I	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Silent_p.I453I	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	453	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		ATCAGCAGATCCACTCTGGAG	0.453													0	0	0	0.000602	0	4	121										T	58265857	C	T	58265857	2	4	121	1	0	0	0	0	0	0	0	1	18146	845	30	1		1	ZNF776	19	58265857	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	13	58265857	863126	508	36543										
HSPA12B	116835	broad.mit.edu	37	chr20	3730479	3730479	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagcagccccatggcaccctCaaggagctctacaaggcatc	10	15	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:3730479C>T	uc002wjd.2	+	10	1123	c.1020C>T	c.(1018-1020)CTC>CTT	p.L340L	HSPA12B_uc010zqi.1_Silent_p.L339L|HSPA12B_uc002wje.2_Silent_p.L253L|HSPA12B_uc010zqj.1_Silent_p.L174L	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	340							ATP binding				0						ATGGCACCCTCAAGGAGCTCT	0.746													0	0	0	0.009096	0	4	13										T	3730479	C	T	3730479	2	4	121	1	0	0	0	0	0	0	0	1	7405	813	29	1		1	HSPA12B	20	3730479	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08		3730479	59295041	509	36544										
SPTLC3	55304	broad.mit.edu	37	chr20	13052966	13052966	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agaaacctttacatgcgaatCagagacaactggaaccggcc	9	11	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:13052966C>G	uc002wod.1	+	3	655	c.366C>G	c.(364-366)ATC>ATG	p.I122M		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	122					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	ACATGCGAATCAGAGACAACT	0.433													0	0	0	0.00361	0	34	83										G	13052966	C	G	13052966	3	3	121	1	0	0	0	0	1	0	0	0	15124	816	29	1	376	1	SPTLC3	20	13052966	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	9322487	13052966	49972554	510	36545										
ID1	3397	broad.mit.edu	37	chr20	30193268	30193268	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aaggccggcaagacagcgagCggtgcgggcgaggtggtgcg	21	9	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:30193268C>G	uc002wwg.1	+	1	177	c.78C>G	c.(76-78)AGC>AGG	p.S26R	ID1_uc002wwh.1_Missense_Mutation_p.S26R|hsa-mir-3193|MI0014238_5'Flank	NM_002165	NP_002156	P41134	ID1_HUMAN	inhibitor of DNA binding 1 isoform a	26					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			AGACAGCGAGCGGTGCGGGCG	0.607													0	0	0	0.001168	0	6	15										G	30193268	C	G	30193268	3	3	121	1	0	0	0	0	1	0	0	0	7489	767	27	4	80	4	ID1	20	30193268	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	17140302	30193268	32832252	511	36546										
CEP250	11190	broad.mit.edu	37	chr20	34057721	34057721	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctcttctctttagggtgacCgagctctctgctctgttgac	10	12	4	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:34057721C>G	uc002xcm.2	+	11	1529	c.858C>G	c.(856-858)ACC>ACG	p.T286T	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_Silent_p.T93T	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	286	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TTAGGGTGACCGAGCTCTCTG	0.418													0	0	0	0.001168	0	5	27										G	34057721	C	G	34057721	2	3	121	1	0	0	0	0	0	0	0	1	3252	639	23	4		4	CEP250	20	34057721	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3864453	34057721	28967799	512	36547										
FITM2	128486	broad.mit.edu	37	chr20	42935833	42935833	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agttggtgagggcaatgaaaGgcagaaggagacagaacgtc	16	5	0	5			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:42935833G>C	uc002xlr.1	-	2	322	c.221C>G	c.(220-222)CCT>CGT	p.P74R		NM_001080472	NP_001073941	Q8N6M3	FITM2_HUMAN	fat storage-inducing transmembrane protein 2	74	Helical; (Potential).				cellular triglyceride homeostasis|lipid particle organization|positive regulation of sequestering of triglyceride|regulation of triglyceride biosynthetic process	integral to endoplasmic reticulum membrane				skin(2)	2						GGCAATGAAAGGCAGAAGGAG	0.577													0	0	0	0.005443	0	24	8										C	42935833	G	C	42935833	3	2	121	1	0	0	0	0	1	0	0	0	5899	1000	35	4	571	4	FITM2	20	42935833	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8878112	42935833	20089687	513	36548										
TTPAL	79183	broad.mit.edu	37	chr20	43115337	43115337	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccatttctaaaggagaaaatAgcaaacagagtaagtgatga	9	5	1	4			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:43115337A>T	uc002xmc.1	+	5	865	c.741A>T	c.(739-741)ATA>ATT	p.I247I	TTPAL_uc002xmd.1_Silent_p.I247I|TTPAL_uc010ggr.1_Silent_p.I60I	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	247	CRAL-TRIO.					intracellular	transporter activity			breast(1)	1						AGGAGAAAATAGCAAACAGAG	0.348													0	0	0	0.000602	0	5	8										T	43115337	A	T	43115337	2	4	121	1	0	0	0	0	0	0	0	1	16734	410	15	5		5	TTPAL	20	43115337	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	179504	43115337	19910183	514	36549										
ZSWIM1	90204	broad.mit.edu	37	chr20	44511647	44511647	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caagaagtttaatccagcatGggagagagtctgtaccatcc	10	9	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:44511647G>T	uc010ghi.2	+	2	529	c.416G>T	c.(415-417)TGG>TTG	p.W139L	ZSWIM1_uc010zxh.1_Missense_Mutation_p.W12L	NM_080603	NP_542170	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	139							zinc ion binding			skin(1)	1		Myeloproliferative disorder(115;0.028)				AATCCAGCATGGGAGAGAGTC	0.527													1	0	7.92952e-12	0.003954	8.58709e-12	23	69										T	44511647	G	T	44511647	3	4	121	1	0	0	0	0	1	0	0	0	18237	1357	47	4	418	4	ZSWIM1	20	44511647	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	1396310	44511647	18513873	515	36550										
CD40	958	broad.mit.edu	37	chr20	44751393	44751393	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cggctttggggtcaagcagaTtggtaagtggctcatctggg	16	7	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:44751393T>C	uc002xrg.1	+	4	478	c.401T>C	c.(400-402)ATT>ACT	p.I134T	CD40_uc002xrf.1_Missense_Mutation_p.I134T|CD40_uc002xrh.1_Missense_Mutation_p.I134T|CD40_uc002xri.1_Missense_Mutation_p.I134T|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	134	Extracellular (Potential).|TNFR-Cys 3.				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	GTCAAGCAGATTGGTAAGTGG	0.597									Immune_Deficiency_with_Hyper-IgM				0	0	0	0.00361	0	57	22										C	44751393	T	C	44751393	3	2	121	1	0	0	0	0	1	0	0	0	3015	1493	52	5	415	5	CD40	20	44751393	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	239746	44751393	18274127	516	36551										
ZNF334	55713	broad.mit.edu	37	chr20	45130608	45130608	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tacattcataagacttctttCctctatgagttatctgatgt	5	8	4	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:45130608C>A	uc002xsc.2	-	5	1554	c.1370G>T	c.(1369-1371)GGA>GTA	p.G457V	ZNF334_uc002xsa.2_Missense_Mutation_p.G480V|ZNF334_uc002xsb.2_Missense_Mutation_p.G419V|ZNF334_uc002xsd.2_Missense_Mutation_p.G419V|ZNF334_uc010ghl.2_Missense_Mutation_p.G456V	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				AGACTTCTTTCCTCTATGAGT	0.388													1	0	1.3612e-06	0.003163	1.41429e-06	13	63										A	45130608	C	A	45130608	3	1	121	1	0	0	0	0	1	0	0	0	17848	855	30	3	676	3	ZNF334	20	45130608	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	379215	45130608	17894912	517	36552										
TSHZ2	128553	broad.mit.edu	37	chr20	51873094	51873094	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agtttgtaacagacgtggatGaagaatagctctgcaggtat	12	5	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:51873094G>A	uc002xwo.2	+	2	4053	c.3097G>A	c.(3097-3099)GAA>AAA	p.E1033K		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	1033					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGACGTGGATGAAGAATAGCT	0.493													0	0	0	0.00361	0	85	41										A	51873094	G	A	51873094	3	1	121	1	0	0	0	0	1	0	0	0	16621	1291	45	1	3103	1	TSHZ2	20	51873094	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	6742486	51873094	11152426	518	36553										
CYP24A1	1591	broad.mit.edu	37	chr20	52788149	52788149	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgtccagcttcatcacttcCcctggtttcattagtttctt	5	12	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:52788149C>A	uc002xwv.2	-	3	908	c.510G>T	c.(508-510)GGG>GGT	p.G170G	CYP24A1_uc002xwu.1_Silent_p.G28G|CYP24A1_uc002xww.2_Silent_p.G170G	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	170					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TCATCACTTCCCCTGGTTTCA	0.507													1	0	2.80507e-11	0.012213	3.03276e-11	29	153										A	52788149	C	A	52788149	2	1	121	1	0	0	0	0	0	0	0	1	4154	610	22	4		4	CYP24A1	20	52788149	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	915055	52788149	10237371	519	36554										
NTSR1	4923	broad.mit.edu	37	chr20	61341220	61341220	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgacggccagcacgccggcGgcctggtgtgcacccccacc	13	20	0	0	rs143560266	byFrequency	TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr20:61341220G>A	uc002ydf.2	+	1	1032	c.661G>A	c.(661-663)GGC>AGC	p.G221S		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	221	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GCACGCCGGCGGCCTGGTGTG	0.672													0	0	0	0.010771	0	30	15										A	61341220	G	A	61341220	3	1	121	1	0	0	0	0	1	0	0	0	10710	1116	39	2	663	2	NTSR1	20	61341220	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	8553071	61341220	1684300	520	36555										
TPTE	7179	broad.mit.edu	37	chr21	10951423	10951423	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	taagaccaggaaaactccaaAtagtctaaaataaacaaata	4	7	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:10951423A>T	uc002yip.1	-	10	657	c.289T>A	c.(289-291)TTT>ATT	p.F97I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.F79I|TPTE_uc002yir.1_Missense_Mutation_p.F59I|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	97	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAAACTCCAAATAGTCTAaaa	0.333													0	0	0	0.009096	0	3	42										T	10951423	A	T	10951423	3	4	121	1	0	0	0	0	1	0	0	0	16427	101	4	5	1426	5	TPTE	21	10951423	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08		10951423	37178472	521	36556										
KRTAP22-1	337979	broad.mit.edu	37	chr21	31973522	31973522	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctatggctgtggtcttagcgGctatggctatgcctgctact	12	10	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:31973522G>A	uc011add.1	+	1	83	c.83G>A	c.(82-84)GGC>GAC	p.G28D	KRTAP6-2_uc011adc.1_5'Flank	NM_181620	NP_853651	Q3MIV0	KR221_HUMAN	keratin associated protein 22-1	28						intermediate filament					0						GGTCTTAGCGGCTATGGCTAT	0.488													0	0	0	0.00361	0	111	9										A	31973522	G	A	31973522	3	1	121	1	0	0	0	0	1	0	0	0	8540	1203	42	2	85	2	KRTAP22-1	21	31973522	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	21022099	31973522	16156373	522	36557										
KRTAP8-1	337879	broad.mit.edu	37	chr21	32185477	32185477	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caacgctatatcccagcgggTagccatagctgccccagtag	10	14	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:32185477T>G	uc002you.2	-	1	94	c.62A>C	c.(61-63)TAC>TCC	p.Y21S		NM_175857	NP_787053	Q8IUC2	KRA81_HUMAN	keratin associated protein 8-1	21	12 X 2 AA repeats of G-[YCGS].					intermediate filament					0						TCCCAGCGGGTAGCCATAGCT	0.602													0	0	0	0.00874	0	36	2										G	32185477	T	G	32185477	3	3	121	1	0	0	0	0	1	0	0	0	8572	1638	57	5	133	5	KRTAP8-1	21	32185477	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	211955	32185477	15944418	523	36558										
TIAM1	7074	broad.mit.edu	37	chr21	32617923	32617924	+	Missense_Mutation	DNP	TG	TG	AA													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gacggcgtgtttggggatgcTgttgtggtctatcccagacc							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:32617923_32617924TG>AA	uc002yow.1	-	7	1936_1937	c.1464_1465CA>TT	c.(1462-1467)AACAGC>AATTGC	p.S489C	TIAM1_uc011adk.1_Missense_Mutation_p.S489C|TIAM1_uc011adl.1_Missense_Mutation_p.S489C|TIAM1_uc002yox.1_Missense_Mutation_p.S97C	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	489	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TTGGGGATGCTGTTGTGGTCTA	0.545													0	0	0	0.004672	0	18	3										AA	32617924	TG	AA	32617923	3	1	121	1	0	0	0	0	1	0	0	0	15887	1580	55	5	3402	5	TIAM1	21	32617923	Missense_Mutation	DNP	TG	TCGA-GV-A3QI-01A-11D-A21Z-08	432446	32617923	15511972	524	36559										
DSCAM	1826	broad.mit.edu	37	chr21	41385013	41385013	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgtttcctttcaaatggcccCgggagtcgagcagtgattct	11	10	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:41385013C>T	uc002yyq.1	-	33	6439	c.5987G>A	c.(5986-5988)CGG>CAG	p.R1996Q	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1996	Cytoplasmic (Potential).			HRPGDLIHLPPYLRMDFLLNRGGPGTSRDLSLGQACLEPQK SRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQR EGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV -> IGQVTSYICLHTLEWTFC (in Ref. 1; AAC17966).	cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CAAATGGCCCCGGGAGTCGAG	0.517													0	0	0	0.003271	0	26	2										T	41385013	C	T	41385013	3	4	121	1	0	0	0	0	1	0	0	0	4768	652	23	2	55	2	DSCAM	21	41385013	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	8767090	41385013	6744882	525	36560										
DSCAM	1826	broad.mit.edu	37	chr21	41416166	41416166	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tggcatagcggtttctcgctGtgggcccagccttggcattc	13	12	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:41416166G>T	uc002yyq.1	-	31	5674	c.5222C>A	c.(5221-5223)ACA>AAA	p.T1741K	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1741	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTTTCTCGCTGTGGGCCCAGC	0.602													1	0	1.01871e-10	0.008871	1.09784e-10	16	1										T	41416166	G	T	41416166	3	4	121	1	0	0	0	0	1	0	0	0	4768	1377	48	4	828	4	DSCAM	21	41416166	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	31153	41416166	6713729	526	36561										
PDE9A	5152	broad.mit.edu	37	chr21	44108087	44108088	+	Frame_Shift_Ins	INS	-	-	C													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tctccatcgaccccaccatgINScccgcgaattcagaacggta							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:44108087_44108088insC	uc002zbm.2	+	3	264_265	c.201_202insC	c.(199-204)ATGCCCfs	p.M67fs	PDE9A_uc002zbn.2_Intron|PDE9A_uc002zbo.2_Frame_Shift_Ins_p.M67fs|PDE9A_uc002zbp.2_Intron|PDE9A_uc002zbq.2_Frame_Shift_Ins_p.A44fs|PDE9A_uc002zbs.2_Intron|PDE9A_uc002zbr.2_Intron|PDE9A_uc002zbt.2_Intron|PDE9A_uc002zbu.2_Frame_Shift_Ins_p.M26fs|PDE9A_uc002zbv.2_Intron|PDE9A_uc002zbw.2_Intron|PDE9A_uc002zbx.2_Frame_Shift_Ins_p.M67fs|PDE9A_uc002zby.2_Intron|PDE9A_uc002zbz.2_Translation_Start_Site|PDE9A_uc002zca.2_Frame_Shift_Ins_p.M26fs|PDE9A_uc002zcb.2_Intron|PDE9A_uc002zcc.2_Frame_Shift_Ins_p.M26fs|PDE9A_uc002zcd.2_Intron|PDE9A_uc002zce.2_Intron|PDE9A_uc002zcf.2_Translation_Start_Site|PDE9A_uc002zcg.2_Intron	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	67_68					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						ACCCCACCATGCCCGCGAATTC	0.574																		50	7	---	---								C	44108088	-	C	44108087	7	5	121	1	0	1	1	0	0	0	0	0	11655	1319	46	0	211	0	PDE9A	21	44108087	Frame_Shift_Ins	INS	-	TCGA-GV-A3QI-01A-11D-A21Z-08	2691921	44108087	4021808	527	36562										
KRTAP10-4	386672	broad.mit.edu	37	chr21	45994247	45994247	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcaggctgcatcagctcctgCacgccctcgtgctgccagca	10	17	2	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr21:45994247C>T	uc002zfk.1	+	1	642	c.612C>T	c.(610-612)TGC>TGT	p.C204C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	204	36 X 5 AA repeats of C-C-X(3).					keratin filament					0						TCAGCTCCTGCACGCCCTCGT	0.662													0	0	0	0.00361	0	51	6										T	45994247	C	T	45994247	2	4	121	1	0	0	0	0	0	0	0	1	8511	718	25	2		2	KRTAP10-4	21	45994247	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1886160	45994247	2135648	528	36563										
CCT8L2	150160	broad.mit.edu	37	chr22	17073279	17073279	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	accaggaacttctgccggccGtgggggccatagcaaggccg	15	13	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:17073279G>A	uc002zlp.1	-	1	422	c.162C>T	c.(160-162)CAC>CAT	p.H54H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	54					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TCTGCCGGCCGTGGGGGCCAT	0.637													0	0	0	0.000602	0	3	94										A	17073279	G	A	17073279	2	1	121	1	0	0	0	0	0	0	0	1	2961	1136	40	2		2	CCT8L2	22	17073279	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		17073279	34231287	529	36564										
C22orf29	79680	broad.mit.edu	37	chr22	19838758	19838758	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	caccacctcctgtggggtacCtaaggacacctcctggtctc	9	16	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:19838758C>T	uc002zqg.2	-	2	1626	c.1027G>A	c.(1027-1029)GGT>AGT	p.G343S	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Missense_Mutation_p.G343S|C22orf29_uc002zqi.2_Missense_Mutation_p.G343S|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	343											0	Colorectal(54;0.0993)					TGTGGGGTACCTAAGGACACC	0.602													0	0	0	0.009096	0	4	2										T	19838758	C	T	19838758	3	4	121	1	0	0	0	0	1	0	0	0	2141	681	24	2	71	2	C22orf29	22	19838758	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2765479	19838758	31465808	530	36565										
MED15	51586	broad.mit.edu	37	chr22	20937496	20937496	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gctgtcgaagtacatcgagcCcctgcgccgcatgatcaaca	10	14	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:20937496C>A	uc002zsp.2	+	12	1714	c.1634C>A	c.(1633-1635)CCC>CAC	p.P545H	MED15_uc002zsq.2_Missense_Mutation_p.P505H|MED15_uc010gso.2_Missense_Mutation_p.P488H|MED15_uc002zsr.2_Missense_Mutation_p.P479H|MED15_uc011ahs.1_Missense_Mutation_p.P479H|MED15_uc002zss.2_Missense_Mutation_p.P424H|MED15_uc011ahu.1_Missense_Mutation_p.P255H|MED15_uc002zst.2_Missense_Mutation_p.P161H|MED15_uc002zsu.2_Missense_Mutation_p.P150H	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	545					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TACATCGAGCCCCTGCGCCGC	0.607													1	0	0.000442599	0.006214	0.000451411	10	9										A	20937496	C	A	20937496	3	1	121	1	0	0	0	0	1	0	0	0	9433	623	22	4	1680	4	MED15	22	20937496	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	1098738	20937496	30367070	531	36566										
LZTR1	8216	broad.mit.edu	37	chr22	21345960	21345960	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acctgctccggggctccccaCcacccccgcagcggcgctac	10	22	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:21345960C>G	uc002zto.2	+	9	938	c.835C>G	c.(835-837)CCA>GCA	p.P279A	LZTR1_uc002ztn.2_Missense_Mutation_p.P238A|LZTR1_uc011ahy.1_Missense_Mutation_p.P260A|LZTR1_uc010gsr.1_Missense_Mutation_p.P150A	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	279	Kelch 4.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGGCTCCCCACCACCCCCGCA	0.647													0	0	0	0.006214	0	7	19										G	21345960	C	G	21345960	3	3	121	1	0	0	0	0	1	0	0	0	9137	507	18	4	869	4	LZTR1	22	21345960	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	408464	21345960	29958606	532	36567										
PPM1F	9647	broad.mit.edu	37	chr22	22277628	22277628	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccgtgatgttgtcgtgggagCcccgctcccgggccgcagcc	15	16	0	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:22277628C>A	uc002zvp.1	-	8	1316	c.1202G>T	c.(1201-1203)GGC>GTC	p.G401V	PPM1F_uc011aik.1_Missense_Mutation_p.G297V	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	401					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		GTCGTGGGAGCCCCGCTCCCG	0.687													1	0	1.7489e-18	0.011902	1.98428e-18	35	35										A	22277628	C	A	22277628	3	1	121	1	0	0	0	0	1	0	0	0	12339	739	26	4	166	4	PPM1F	22	22277628	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	931668	22277628	29026938	533	36568										
CRYBA4	1413	broad.mit.edu	37	chr22	27021570	27021570	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cgagaggctcacctccttccGgcctgcggcctgtgctgtaa	12	15	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:27021570G>A	uc003acz.3	+	4	319	c.284G>A	c.(283-285)CGG>CAG	p.R95Q		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	95	Beta/gamma crystallin 'Greek key' 2.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0						ACCTCCTTCCGGCCTGCGGCC	0.537													0	0	0	0.00361	0	56	64										A	27021570	G	A	27021570	3	1	121	1	0	0	0	0	1	0	0	0	3909	1116	39	2	294	2	CRYBA4	22	27021570	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	4743942	27021570	24282996	534	36569										
AP1B1	162	broad.mit.edu	37	chr22	29763219	29763219	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcttggtcgtggtgaaatatTttgagtcagtcattttggtc	11	5	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:29763219T>G	uc003afj.2	-	2	198	c.14A>C	c.(13-15)AAA>ACA	p.K5T	AP1B1_uc003afi.2_Missense_Mutation_p.K5T|AP1B1_uc003afk.2_Missense_Mutation_p.K5T|AP1B1_uc003afl.2_Missense_Mutation_p.K5T	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	5					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GGTGAAATATTTTGAGTCAGT	0.443													0	0	0	0.004656	0	13	43										G	29763219	T	G	29763219	3	3	121	1	0	0	0	0	1	0	0	0	731	1841	64	5	2923	5	AP1B1	22	29763219	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	2741649	29763219	21541347	535	36570										
PLA2G3	50487	broad.mit.edu	37	chr22	31532738	31532738	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcccagcagctcccaaagcAtgttggtaacctcgggtggg	13	12	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:31532738A>G	uc003aka.2	-	6	1376	c.1247T>C	c.(1246-1248)ATG>ACG	p.M416T		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	416					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						CTCCCAAAGCATGTTGGTAAC	0.627													0	0	0	0.001168	0	5	157										G	31532738	A	G	31532738	3	3	121	1	0	0	0	0	1	0	0	0	12000	217	8	5	290	5	PLA2G3	22	31532738	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1769519	31532738	19771828	536	36571										
TRIOBP	11078	broad.mit.edu	37	chr22	38119892	38119892	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatcccagagcctcctctccCagtagagctacacgagacaa	7	15	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:38119892C>G	uc003atr.2	+	7	1600	c.1329C>G	c.(1327-1329)CCC>CCG	p.P443P	TRIOBP_uc003atu.2_Silent_p.P271P|TRIOBP_uc003atq.1_Silent_p.P443P|TRIOBP_uc003ats.1_Silent_p.P271P	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	443					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCTCCTCTCCCAGTAGAGCTA	0.582													0	0	0	0.00245	0	5	111										G	38119892	C	G	38119892	2	3	121	1	0	0	0	0	0	0	0	1	16550	581	21	4		4	TRIOBP	22	38119892	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6587154	38119892	13184674	537	36572										
TRIOBP	11078	broad.mit.edu	37	chr22	38120039	38120039	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	aatcccagagcctcctctccCagtagagctacacgagacaa	7	15	1	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:38120039C>G	uc003atr.2	+	7	1747	c.1476C>G	c.(1474-1476)CCC>CCG	p.P492P	TRIOBP_uc003atu.2_Silent_p.P320P|TRIOBP_uc003atq.1_Silent_p.P492P|TRIOBP_uc003ats.1_Silent_p.P320P	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	492					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCTCCTCTCCCAGTAGAGCTA	0.582													0	0	0	0.00361	0	49	58										G	38120039	C	G	38120039	2	3	121	1	0	0	0	0	0	0	0	1	16550	581	21	4		4	TRIOBP	22	38120039	Silent	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	147	38120039	13184527	538	36573										
DNAJB7	150353	broad.mit.edu	37	chr22	41257777	41257777	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcaaaatgacttccacctccGtttaatccttctgtgccata	4	13	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:41257777G>A	uc003azj.2	-	1	354	c.222C>T	c.(220-222)AAC>AAT	p.N74N	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_RNA|XPNPEP3_uc003azf.1_RNA|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	74					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1						TTCCACCTCCGTTTAATCCTT	0.358													0	0	0	0.00361	0	66	1										A	41257777	G	A	41257777	2	1	121	1	0	0	0	0	0	0	0	1	4625	1136	40	2		2	DNAJB7	22	41257777	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3137738	41257777	10046789	539	36574										
EFCAB6	64800	broad.mit.edu	37	chr22	44031097	44031097	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atcccagtgtcttccagtacCtgacgagggagacaggggag	14	10	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:44031097C>T	uc003bdy.1	-	18	2199	c.1984_splice	c.e18-1	p.V662_splice	EFCAB6_uc003bdz.1_Splice_Site_p.V510_splice|EFCAB6_uc010gzi.1_Splice_Site_p.V510_splice|EFCAB6_uc010gzj.1_Intron|EFCAB6_uc010gzk.1_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				CTTCCAGTACCTGACGAGGGA	0.572													0	0	0	0.00361	0	37	40										T	44031097	C	T	44031097	5	4	121	1	0	0	0	0	0	0	1	0	4939	695	24	2	2582	2	EFCAB6	22	44031097	Splice_Site	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	2773320	44031097	7273469	540	36575										
FBLN1	2192	broad.mit.edu	37	chr22	45972913	45972913	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctgccagccaggctaacatcAtcttcgacatcacggaaggg	10	13	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chr22:45972913A>G	uc003bgj.1	+	16	2044	c.1897A>G	c.(1897-1899)ATC>GTC	p.I633V		NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	633					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GGCTAACATCATCTTCGACAT	0.552													0	0	0	0.013114	0	36	101										G	45972913	A	G	45972913	3	3	121	1	0	0	0	0	1	0	0	0	5698	217	8	5	2439	5	FBLN1	22	45972913	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	1941816	45972913	5331653	541	36576										
SFRS17A	8227	broad.mit.edu	37	chrX	1719725	1719725	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gagcggctgctgagcatcctGctgagcaagaagccggacga	15	11	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:1719725G>T	uc004cqa.2	+	5	1522	c.1326G>T	c.(1324-1326)CTG>CTT	p.L442L	SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_Intron	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	442	PKA-RI-alpha subunit binding domain.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGAGCATCCTGCTGAGCAAGA	0.692													1	0	3.86212e-05	0.008291	3.96328e-05	5	8										T	1719725	G	T	1719725	2	4	121	1	0	0	0	0	0	0	0	1	14173	1306	46	4		4	SFRS17A	23	1719725	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08		1719725	153550835	542	36577										
ZBED1	9189	broad.mit.edu	37	chrX	2407722	2407722	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccaggagacgcggttgctcaCcagcatgcagtgggccacgt	14	13	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:2407722C>T	uc004cqg.2	-	2	1240	c.1039G>A	c.(1039-1041)GTG>ATG	p.V347M	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.V347M	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	347						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGTTGCTCACCAGCATGCAG	0.617													0	0	0	0.012319	0	20	13										T	2407722	C	T	2407722	3	4	121	1	0	0	0	0	1	0	0	0	17514	507	18	2	1049	2	ZBED1	23	2407722	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	687997	2407722	152862838	543	36578										
CLCN4	1183	broad.mit.edu	37	chrX	10155598	10155598	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	catatgggagttcatcaagaGcctgctggatgcctggtcgg	14	9	2	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:10155598G>T	uc004csy.3	+	4	618	c.188G>T	c.(187-189)AGC>ATC	p.S63I	CLCN4_uc011mid.1_Intron	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	63	Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TTCATCAAGAGCCTGCTGGAT	0.542													1	0	8.60899e-122	0.00361	1.03122e-121	184	8										T	10155598	G	T	10155598	3	4	121	1	0	0	0	0	1	0	0	0	3465	971	34	4	194	4	CLCN4	23	10155598	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	7747876	10155598	145114962	544	36579										
NHS	4810	broad.mit.edu	37	chrX	17739625	17739625	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gaggccgaaaaacccaatacAcaatatcccttccacactgg	6	14	0	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:17739625A>G	uc004cxx.2	+	4	1255	c.917A>G	c.(916-918)CAC>CGC	p.H306R	NHS_uc011mix.1_Missense_Mutation_p.H327R|NHS_uc004cxy.2_Missense_Mutation_p.H150R|NHS_uc004cxz.2_Missense_Mutation_p.H129R|NHS_uc004cya.2_Missense_Mutation_p.H29R	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	306						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AACCCAATACACAATATCCCT	0.483													0	0	0	0.00361	0	67	2										G	17739625	A	G	17739625	3	3	121	1	0	0	0	0	1	0	0	0	10411	159	6	5	1036	5	NHS	23	17739625	Missense_Mutation	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	7584027	17739625	137530935	545	36580										
PTCHD1	139411	broad.mit.edu	37	chrX	23411277	23411277	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acactactgcccagcaaaagTacttcagcaactacagtcct	5	14	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:23411277T>A	uc004dal.3	+	3	1650	c.1642T>A	c.(1642-1644)TAC>AAC	p.Y548N		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	548					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CCAGCAAAAGTACTTCAGCAA	0.433													0	0	0	0.00278	0	18	59										A	23411277	T	A	23411277	3	1	121	1	0	0	0	0	1	0	0	0	12732	1638	57	5	1652	5	PTCHD1	23	23411277	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	5671652	23411277	131859283	546	36581										
MAGEB2	4113	broad.mit.edu	37	chrX	30237164	30237164	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ccctgagatcctcaagaaagCctctgagggcctcagtgttg	11	12	3	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:30237164C>G	uc004dbz.2	+	2	570	c.467C>G	c.(466-468)GCC>GGC	p.A156G		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	156	MAGE.						protein binding			ovary(1)	1						CTCAAGAAAGCCTCTGAGGGC	0.448													0	0	0	0.006214	0	8	0										G	30237164	C	G	30237164	3	3	121	1	0	0	0	0	1	0	0	0	9176	739	26	4	469	4	MAGEB2	23	30237164	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6825887	30237164	125033396	547	36582										
CASK	8573	broad.mit.edu	37	chrX	41437603	41437603	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tcctacttaccattggttcaTctgtgttcttttgaaactgt	6	9	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:41437603T>C	uc004dfl.3	-	15	1539	c.1493A>G	c.(1492-1494)GAT>GGT	p.D498G	CASK_uc004dfj.3_Missense_Mutation_p.D61G|CASK_uc004dfk.3_Missense_Mutation_p.D313G|CASK_uc004dfm.3_Missense_Mutation_p.D498G|CASK_uc004dfn.3_Missense_Mutation_p.D492G	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	498	PDZ.				cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						CATTGGTTCATCTGTGTTCTT	0.413													0	0	0	0.009718	0	36	0										C	41437603	T	C	41437603	3	2	121	1	0	0	0	0	1	0	0	0	2665	1435	50	5	1339	5	CASK	23	41437603	Missense_Mutation	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	11200439	41437603	113832957	548	36583										
RRAGB	10325	broad.mit.edu	37	chrX	55777615	55777615	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tccgaacatctatctgggatGaaaccctctataaggtgtgt	9	9	3	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:55777615G>T	uc004dup.2	+	7	1333	c.682G>T	c.(682-684)GAA>TAA	p.E228*	RRAGB_uc004duq.2_Nonsense_Mutation_p.E200*	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	228					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						TATCTGGGATGAAACCCTCTA	0.363													1	0	2.54575e-18	0.010504	2.88345e-18	14	0										T	55777615	G	T	55777615	4	4	121	1	0	0	0	0	0	1	0	0	13673	1291	45	3	708	3	RRAGB	23	55777615	Nonsense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	14340012	55777615	99492945	549	36584										
OPHN1	4983	broad.mit.edu	37	chrX	67431998	67431998	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ttgtatgggaggaaatcctgTgtgagctccacagtcaggct	13	8	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:67431998T>C	uc004dww.3	-	8	948	c.654A>G	c.(652-654)ACA>ACG	p.T218T	OPHN1_uc011mpg.1_Silent_p.T218T|OPHN1_uc004dwx.2_Silent_p.T218T	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	218					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						GGAAATCCTGTGTGAGCTCCA	0.403													0	0	0	0.007413	0	13	1										C	67431998	T	C	67431998	2	2	121	1	0	0	0	0	0	0	0	1	10875	1683	59	5		5	OPHN1	23	67431998	Silent	SNP	T	TCGA-GV-A3QI-01A-11D-A21Z-08	11654383	67431998	87838562	550	36585										
ACRC	93953	broad.mit.edu	37	chrX	70823918	70823918	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cagcagtgatgattcggaagCtcccgacgacagcagtgatg	13	10	0	3			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:70823918C>T	uc004eae.2	+	8	1292	c.791C>T	c.(790-792)GCT>GTT	p.A264V	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	264	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					GATTCGGAAGCTCCCGACGAC	0.557													0	0	0	0.008291	0	3	39										T	70823918	C	T	70823918	3	4	121	1	0	0	0	0	1	0	0	0	171	797	28	2	817	2	ACRC	23	70823918	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	3391920	70823918	84446642	551	36586										
ZMAT1	84460	broad.mit.edu	37	chrX	101153125	101153125	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	acatgcatcttcattttcttAccaggcacttcattttgttc	4	11	4	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:101153125A>T	uc011mrl.1	-	4	608	c.297T>A	c.(295-297)GGT>GGA	p.G99G	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						TCATTTTCTTACCAGGCACTT	0.313													0	0	0	0.008361	0	22	0										T	101153125	A	T	101153125	2	4	121	1	0	0	0	0	0	0	0	1	17688	378	14	5		5	ZMAT1	23	101153125	Silent	SNP	A	TCGA-GV-A3QI-01A-11D-A21Z-08	30329207	101153125	54117435	552	36587										
PLS3	5358	broad.mit.edu	37	chrX	114871237	114871237	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgcttagatgggcaaactttCatttggaaaactcgggctgg	12	7	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:114871237C>G	uc004eqd.2	+	8	1228	c.838C>G	c.(838-840)CAT>GAT	p.H280D	PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Missense_Mutation_p.H258D|PLS3_uc004eqe.2_Missense_Mutation_p.H280D|PLS3_uc011mtg.1_Missense_Mutation_p.H253D|PLS3_uc011mth.1_Missense_Mutation_p.H235D	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	280	CH 2.|Actin-binding 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						GGCAAACTTTCATTTGGAAAA	0.408													0	0	0	0.002299	0	17	43										G	114871237	C	G	114871237	3	3	121	1	0	0	0	0	1	0	0	0	12108	826	29	1	864	1	PLS3	23	114871237	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	13718112	114871237	40399323	553	36588										
UBE2A	7319	broad.mit.edu	37	chrX	118708895	118708895	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	atcctccagccggagtcagcGgggctccgtccgagaacaac	12	15	1	1			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:118708895G>A	uc004erl.2	+	2	252	c.76G>A	c.(76-78)GGG>AGG	p.G26R	UBE2A_uc004erm.2_Missense_Mutation_p.G26R|UBE2A_uc004ern.2_RNA|UBE2A_uc004ero.2_RNA	NM_003336	NP_003327	P49459	UBE2A_HUMAN	ubiquitin-conjugating enzyme E2A isoform 1	26					histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						CGGAGTCAGCGGGGCTCCGTC	0.657								Direct_reversal_of_damage|Rad6_pathway					0	0	0	0.00361	0	61	3										A	118708895	G	A	118708895	3	1	121	1	0	0	0	0	1	0	0	0	16841	1116	39	2	82	2	UBE2A	23	118708895	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	3837658	118708895	36561665	554	36589										
ODZ1	10178	broad.mit.edu	37	chrX	123518470	123518496	+	In_Frame_Del	DEL	TTCATCACTGTAGTAGTTATGACCTGA	TTCATCACTGTAGTAGTTATGACCTGA	-													0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	cactgaagattttggtgtgtTtcatcactgtagtagttatg							TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:123518470_123518496delTTCATCACTGTAGTAGTTATGACCTGA	uc004euj.2	-	29	6328_6354	c.6264_6290delTCAGGTCATAACTACTACAGTGATGAA	c.(6262-6291)AATCAGGTCATAACTACTACAGTGATGAAA>AAA	p.NQVITTTVM2088del	ODZ1_uc011muj.1_In_Frame_Del_p.NQVITTTVM2094del|ODZ1_uc010nqy.2_In_Frame_Del_p.NQVITTTVM2095del	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2088_2096	YD 15.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTTGGTGTGTTTCATCACTGTAGTAGTTATGACCTGATTTAAATCGT	0.366																		8	76	---	---								-	123518496	TTCATCACTGTAGTAGTTATGACCTGA	-	123518470	7	5	121	1	0	1	0	1	0	0	0	0	10834	1841	64	0	1899	0	ODZ1	23	123518470	In_Frame_Del	DEL	TTCATCACTGTAGTAGTTATGACCTGA	TCGA-GV-A3QI-01A-11D-A21Z-08	4809575	123518470	31752090	555	36590										
ENOX2	10495	broad.mit.edu	37	chrX	129801714	129801714	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	agcttctgagaatttggaatCatctgaaaaaaatatatttt	6	4	3	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:129801714C>A	uc004evw.2	-	9	1202	c.784G>T	c.(784-786)GAT>TAT	p.D262Y	ENOX2_uc004evx.2_Missense_Mutation_p.D233Y|ENOX2_uc004evy.2_Missense_Mutation_p.D233Y|ENOX2_uc004evv.2_Missense_Mutation_p.D89Y	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	262					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						AATTTGGAATCATCTGAAAAA	0.403													1	0	5.9392e-07	0.001168	6.18048e-07	5	10										A	129801714	C	A	129801714	3	1	121	1	0	0	0	0	1	0	0	0	5127	826	29	3	1080	3	ENOX2	23	129801714	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	6283244	129801714	25468846	556	36591										
IGSF1	3547	broad.mit.edu	37	chrX	130409559	130409559	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	tgctagtaccagatatattgGtgatggggaatgccccgtca	12	8	1	2			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:130409559G>A	uc004ewd.2	-	16	3315	c.3077C>T	c.(3076-3078)ACC>ATC	p.T1026I	IGSF1_uc004ewe.3_Missense_Mutation_p.T1020I|IGSF1_uc004ewf.2_Missense_Mutation_p.T1006I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1026	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						AGATATATTGGTGATGGGGAA	0.517													0	0	0	0.00361	0	89	2										A	130409559	G	A	130409559	3	1	121	1	0	0	0	0	1	0	0	0	7596	1261	44	2	953	2	IGSF1	23	130409559	Missense_Mutation	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	607845	130409559	24861001	557	36592										
MAGEC1	9947	broad.mit.edu	37	chrX	140994913	140994913	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	ctcctcagggggaggactccCtgtctcctcactactttcct	8	16	3	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:140994913C>A	uc004fbt.2	+	4	2009	c.1723C>A	c.(1723-1725)CTG>ATG	p.L575M	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	575							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GGAGGACTCCCTGTCTCCTCA	0.597										HNSCC(15;0.026)			1	0	3.09899e-07	0.004482	3.23499e-07	6	301										A	140994913	C	A	140994913	3	1	121	1	0	0	0	0	1	0	0	0	9180	680	24	4	1729	4	MAGEC1	23	140994913	Missense_Mutation	SNP	C	TCGA-GV-A3QI-01A-11D-A21Z-08	10585354	140994913	14275647	558	36593										
ATP2B3	492	broad.mit.edu	37	chrX	152807362	152807362	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.186379928315412	104	5.31493568747149e-18	2.44507944508351	4.10125505211657	1.68246835161247	0.51358335859283	0.695477464761124	61	gtggctgcgctggtggtgggGgacattgcccaggtcaagta	18	8	1	0			TCGA-GV-A3QI-01A-11D-A21Z-08	TCGA-GV-A3QI-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33a9da52-5471-456f-84cb-13c5de5b0994	59c24b21-b1e8-4752-bd0a-b48dd802643b	g.chrX:152807362G>A	uc004fht.1	+	3	768	c.642G>A	c.(640-642)GGG>GGA	p.G214G	ATP2B3_uc004fhs.1_Silent_p.G214G	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	214	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGTGGTGGGGGACATTGCCC	0.637													0	0	0	0.00361	0	59	9										A	152807362	G	A	152807362	2	1	121	1	0	0	0	0	0	0	0	1	1141	1219	43	2		2	ATP2B3	23	152807362	Silent	SNP	G	TCGA-GV-A3QI-01A-11D-A21Z-08	11812449	152807362	2463198	559	36594										
CELA2A	63036	broad.mit.edu	37	chr1	15789243	15789243	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cccagctcctccaggacctaCcgcgtggggctgggccggca	14	17	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:15789243C>T	uc001awk.2	+	4	269	c.243C>T	c.(241-243)TAC>TAT	p.Y81Y		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	81	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CCAGGACCTACCGCGTGGGGC	0.612													0	0	0	0.039052	0	43	81										T	15789243	C	T	15789243	2	4	122	1	0	0	0	0	0	0	0	1	3211	518	18	2		2	CELA2A	1	15789243	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		15789243	233461378	1	36595										
CNKSR1	10256	broad.mit.edu	37	chr1	26514993	26514993	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggctgggtcccactcagcctCggtgagtggggggctgccgg	19	12	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:26514993C>T	uc001bln.3	+	18	1668	c.1610C>T	c.(1609-1611)TCG>TTG	p.S537L	CNKSR1_uc001blm.3_Missense_Mutation_p.S530L|CNKSR1_uc009vsd.2_Missense_Mutation_p.S272L|CNKSR1_uc009vse.2_Missense_Mutation_p.S272L|CNKSR1_uc001blo.2_Missense_Mutation_p.S272L|CATSPER4_uc010oey.1_5'Flank|CATSPER4_uc010oez.1_5'Flank|CATSPER4_uc009vsf.2_5'Flank	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	537					Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CACTCAGCCTCGGTGAGTGGG	0.637													0	0	0	0.038147	0	7	13										T	26514993	C	T	26514993	3	4	122	1	0	0	0	0	1	0	0	0	3606	898	31	1	1659	1	CNKSR1	1	26514993	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	10725750	26514993	222735628	2	36596										
CNKSR1	10256	broad.mit.edu	37	chr1	26515960	26515960	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cacagaacagtccccccactCcctgccctctgaccctgaag	6	20	1	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:26515960C>G	uc001bln.3	+	21	2142	c.2084C>G	c.(2083-2085)TCC>TGC	p.S695C	CNKSR1_uc001blm.3_Missense_Mutation_p.S688C|CNKSR1_uc009vsd.2_Missense_Mutation_p.S430C|CNKSR1_uc009vse.2_Missense_Mutation_p.S430C|CNKSR1_uc001blo.2_Missense_Mutation_p.S430C|CATSPER4_uc010oey.1_5'Flank|CATSPER4_uc010oez.1_5'Flank|CATSPER4_uc009vsf.2_5'Flank	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	695					Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCCCCACTCCCTGCCCTCT	0.642													0	0	0	0.11126	0	42	84										G	26515960	C	G	26515960	3	3	122	1	0	0	0	0	1	0	0	0	3606	855	30	1	2145	1	CNKSR1	1	26515960	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	967	26515960	222734661	3	36597										
ARID1A	8289	broad.mit.edu	37	chr1	27107085	27107102	+	In_Frame_Del	DEL	GCGGGCTGCCCGCGCGCT	GCGGGCTGCCCGCGCGCT	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	actagtgtggacatgatgcgGcgggctgcccgcgcgctgct							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08			GCGGGCTGCCCGCGCGCT	-	GCGGGCTGCCCGCGCGCT	GCGGGCTGCCCGCGCGCT		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:27107085_27107102delGCGGGCTGCCCGCGCGCT	uc001bmv.1	+	20	7069_7086	c.6696_6713delGCGGGCTGCCCGCGCGCT	c.(6694-6714)CGGCGGGCTGCCCGCGCGCTG>CGG	p.RAARAL2233del	ARID1A_uc001bmu.1_In_Frame_Del_p.RAARAL2016del|ARID1A_uc001bmx.1_In_Frame_Del_p.RAARAL1079del|ARID1A_uc009vsm.1_In_Frame_Del_p.RAARAL561del|ARID1A_uc009vsn.1_In_Frame_Del_p.RAARAL475del	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2233_2238					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.L2238fs*40(1)|p.A2235fs*32(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ACATGATGCGGCGGGCTGCCCGCGCGCTGCTTGCCTTG	0.573			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													27	123	---	---								-	27107102	GCGGGCTGCCCGCGCGCT	-	27107085	7	5	122	1	0	1	0	1	0	0	0	0	913	1190	42	0	6774	0	ARID1A	1	27107085	In_Frame_Del	DEL	GCGGGCTGCCCGCGCGCT	TCGA-GV-A3QK-01B-11D-A23M-08	591125	27107085	222143536	4	36598										
FGR	2268	broad.mit.edu	37	chr1	27943478	27943478	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aatgcttcacatgatcgcctCtggtctgatcccagtcccgg	9	14	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:27943478C>G	uc001boj.2	-	5	718	c.572G>C	c.(571-573)AGA>ACA	p.R191T	FGR_uc001boi.2_5'Flank|FGR_uc001bok.2_Missense_Mutation_p.R191T|FGR_uc001bol.2_Missense_Mutation_p.R191T|FGR_uc001bom.2_Missense_Mutation_p.R191T	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	191	SH2.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ATGATCGCCTCTGGTCTGATC	0.557													0	0	0	0.048971	0	50	94										G	27943478	C	G	27943478	3	3	122	1	0	0	0	0	1	0	0	0	5874	913	32	1	1045	1	FGR	1	27943478	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	836393	27943478	221307143	5	36599										
BAI2	576	broad.mit.edu	37	chr1	32204223	32204223	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cagctggcgcaatggggatcCgtggtcccctggggagcaaa	16	11	0	0	rs140870509		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:32204223C>T	uc001btn.2	-	17	2964	c.2610G>A	c.(2608-2610)ACG>ACA	p.T870T	BAI2_uc001btm.2_5'Flank|BAI2_uc001btp.1_5'Flank|BAI2_uc010ogn.1_5'Flank|BAI2_uc010ogo.1_Silent_p.T512T|BAI2_uc010ogp.1_Silent_p.T803T|BAI2_uc010ogq.1_Silent_p.T870T|BAI2_uc001bto.2_Silent_p.T870T|BAI2_uc001btq.1_Silent_p.T803T	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	870	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.T870T(1)		lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AATGGGGATCCGTGGTCCCCT	0.632													0	0	0	0.047766	0	8	13										T	32204223	C	T	32204223	2	4	122	1	0	0	0	0	0	0	0	1	1299	639	23	2		2	BAI2	1	32204223	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	4260745	32204223	217046398	6	36600										
GNL2	29889	broad.mit.edu	37	chr1	38032516	38032516	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccctctgagtcattggtcttCtttttgttcctgttcctatt	6	11	4	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:38032516C>G	uc001cbk.2	-	16	2299	c.2136G>C	c.(2134-2136)AAG>AAC	p.K712N		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	712					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				CATTGGTCTTCTTTTTGTTCC	0.388													0	0	0	0.048971	0	52	108										G	38032516	C	G	38032516	3	3	122	1	0	0	0	0	1	0	0	0	6536	912	32	1	63	1	GNL2	1	38032516	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	5828293	38032516	211218105	7	36601										
DMBX1	127343	broad.mit.edu	37	chr1	46976774	46976774	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cagcccccacgtctgcctggCagcgacccccctgctgagct	10	20	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:46976774C>A	uc001cpx.2	+	3	531	c.516C>A	c.(514-516)GGC>GGA	p.G172G	DMBX1_uc001cpw.2_Silent_p.G167G	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	172					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					GTCTGCCTGGCAGCGACCCCC	0.662													1	0	1.36161e-19	0.069456	1.46477e-19	33	114										A	46976774	C	A	46976774	2	1	122	1	0	0	0	0	0	0	0	1	4578	697	25	4		4	DMBX1	1	46976774	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	8944258	46976774	202273847	8	36602										
HSPB11	51668	broad.mit.edu	37	chr1	54405716	54405716	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgatgtagctaaaatcacttCggacccttcagagctcagac	8	11	3	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:54405716C>T	uc001cwh.2	-	2	116	c.40G>A	c.(40-42)GAA>AAA	p.E14K	HSPB11_uc001cwi.1_Missense_Mutation_p.E14K	NM_016126	NP_057210	Q9Y547	HSB11_HUMAN	heat shock protein family B (small), member 11	14					cell adhesion|response to stress						0						AAAATCACTTCGGACCCTTCA	0.328													0	0	0	0.038395	0	14	31										T	54405716	C	T	54405716	3	4	122	1	0	0	0	0	1	0	0	0	7419	893	31	1	414	1	HSPB11	1	54405716	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	7428942	54405716	194844905	9	36603										
LRRIQ3	127255	broad.mit.edu	37	chr1	74506961	74506961	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgcttttagtttttgcttaaCaatcaggcttttctctttta	5	7	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:74506961C>A	uc001dfy.3	-	7	1846	c.1654G>T	c.(1654-1656)GTT>TTT	p.V552F	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	552										ovary(2)	2						TTTTGCTTAACAATCAGGCTT	0.313													1	0	2.2171e-23	0.041601	2.4094e-23	32	45										A	74506961	C	A	74506961	3	1	122	1	0	0	0	0	1	0	0	0	9030	478	17	4	228	4	LRRIQ3	1	74506961	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	20101245	74506961	174743660	10	36604										
GTF2B	2959	broad.mit.edu	37	chr1	89323052	89323052	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggaagacaaaggttggaacaGaacctggacatgaagtcccc	12	9	0	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:89323052G>A	uc001dmo.3	-	6	773	c.654C>T	c.(652-654)TTC>TTT	p.F218F		NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	218	2.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		GGTTGGAACAGAACCTGGACA	0.433													0	0	0	0.083992	0	26	50										A	89323052	G	A	89323052	2	1	122	1	0	0	0	0	0	0	0	1	6855	933	33	1		1	GTF2B	1	89323052	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	14816091	89323052	159927569	11	36605										
COL11A1	1301	broad.mit.edu	37	chr1	103488345	103488345	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tggtacacctggaccaaattCttcattaggggggcttgttg	12	8	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:103488345C>G	uc001dul.2	-	8	1516	c.1198G>C	c.(1198-1200)GAA>CAA	p.E400Q	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E412Q|COL11A1_uc001dun.2_Missense_Mutation_p.E361Q|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	400	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGACCAAATTCTTCATTAGGG	0.363													0	0	0	0.108266	0	28	81										G	103488345	C	G	103488345	3	3	122	1	0	0	0	0	1	0	0	0	3667	922	32	1	4462	1	COL11A1	1	103488345	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	14165293	103488345	145762276	12	36606										
ADAR	103	broad.mit.edu	37	chr1	154562706	154562706	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttgagaggaggagcatagttCttctgagactggcccctgtc	13	9	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:154562706C>G	uc001ffh.2	-	7	2650	c.2450G>C	c.(2449-2451)AGA>ACA	p.R817T	ADAR_uc001ffj.2_Intron|ADAR_uc001ffi.2_Intron|ADAR_uc001ffk.2_Missense_Mutation_p.R522T	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	817					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GAGCATAGTTCTTCTGAGACT	0.552													0	0	0	0.074837	0	33	60										G	154562706	C	G	154562706	3	3	122	1	0	0	0	0	1	0	0	0	281	913	32	1	1266	1	ADAR	1	154562706	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	51074361	154562706	94687915	13	36607										
SELP	6403	broad.mit.edu	37	chr1	169566333	169566333	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cacaagagaaatggcaggtgGagccaacattgaattctcca	10	9	1	2	rs143148749		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:169566333G>A	uc001ggi.3	-	11	1852	c.1787C>T	c.(1786-1788)TCC>TTC	p.S596F	SELP_uc001ggh.2_Missense_Mutation_p.S431F|SELP_uc009wvr.2_Missense_Mutation_p.S596F	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	596	Extracellular (Potential).|Sushi 7.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding	p.S596T(1)		ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	ATGGCAGGTGGAGCCAACATT	0.498													0	0	0	0.030593	0	29	33										A	169566333	G	A	169566333	3	1	122	1	0	0	0	0	1	0	0	0	14019	1174	41	1	729	1	SELP	1	169566333	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	15003627	169566333	79684288	14	36608										
CHIT1	1118	broad.mit.edu	37	chr1	203194936	203194936	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	caagtccttgggcaggaagcGagcctccccctgtctgtact	11	14	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:203194936G>A	uc001gzn.2	-	3	214	c.118C>T	c.(118-120)CGC>TGC	p.R40C	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.R50C	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	40					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						GGCAGGAAGCGAGCCTCCCCC	0.577													0	0	0	0.059317	0	32	52										A	203194936	G	A	203194936	3	1	122	1	0	0	0	0	1	0	0	0	3346	1058	37	1	1318	1	CHIT1	1	203194936	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	33628603	203194936	46055685	15	36609										
NFASC	23114	broad.mit.edu	37	chr1	204923365	204923365	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tcaacatcgccaaggaccccCgggtgtccatgaggaggagg	14	12	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr1:204923365C>T	uc001hbj.2	+	6	593	c.265C>T	c.(265-267)CGG>TGG	p.R89W	NFASC_uc001hbh.2_Missense_Mutation_p.R89W|NFASC_uc010pqz.1_Missense_Mutation_p.R83W|NFASC_uc010pra.1_Missense_Mutation_p.R83W|NFASC_uc001hbi.2_Missense_Mutation_p.R83W|NFASC_uc009xbg.1_Missense_Mutation_p.R156W|NFASC_uc010prb.1_Missense_Mutation_p.R83W|NFASC_uc010prc.1_5'UTR	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	89	Ig-like C2-type 1.|Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CAAGGACCCCCGGGTGTCCAT	0.602													0	0	0	0.049695	0	19	53										T	204923365	C	T	204923365	3	4	122	1	0	0	0	0	1	0	0	0	10359	643	23	2	279	2	NFASC	1	204923365	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	1728429	204923365	44327256	16	36610										
MAP4K3	8491	broad.mit.edu	37	chr2	39505628	39505628	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	accaaatatcaagtactgatCtgaaataaaagtaattcact	4	7	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:39505628C>T	uc002rro.2	-	24	1806	c.1715_splice	c.e24-1	p.D572_splice	MAP4K3_uc002rrp.2_Splice_Site_p.D551_splice|MAP4K3_uc010yns.1_Splice_Site_p.D125_splice	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase						JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				AAGTACTGATCTGAAATAAAA	0.254													0	0	0	0.045705	0	31	27										T	39505628	C	T	39505628	5	4	122	1	0	0	0	0	0	0	1	0	9261	927	32	1	1014	1	MAP4K3	2	39505628	Splice_Site	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		39505628	203693745	17	36611										
ZFP36L2	678	broad.mit.edu	37	chr2	43452831	43452832	+	Frame_Shift_Ins	INS	-	-	C													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggggcggcggccacaggcgtINSccccaccgccttcttgtcca							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:43452831_43452832insC	uc002rsv.3	-	2	402_403	c.111_112insG	c.(109-114)GGGACGfs	p.G37fs	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	37_38					cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				GCCACAGGCGTCCCCACCGCCT	0.663																		21	19	---	---								C	43452832	-	C	43452831	7	5	122	1	0	1	1	0	0	0	0	0	17644	1667	58	0	1376	0	ZFP36L2	2	43452831	Frame_Shift_Ins	INS	-	TCGA-GV-A3QK-01B-11D-A23M-08	3947203	43452831	199746542	18	36612										
KLRAQ1	129285	broad.mit.edu	37	chr2	48698230	48698230	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttccctcctgtttagttctCacaataccttcatgaaaatg	4	11	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:48698230C>T	uc002rwm.2	+	10	1087	c.902C>T	c.(901-903)TCA>TTA	p.S301L	KLRAQ1_uc002rwi.1_Missense_Mutation_p.S301L|KLRAQ1_uc002rwj.2_Missense_Mutation_p.S301L|KLRAQ1_uc002rwl.2_Missense_Mutation_p.S255L|KLRAQ1_uc002rwk.2_Missense_Mutation_p.S301L|KLRAQ1_uc010yok.1_Missense_Mutation_p.S301L	NM_001135629	NP_001129101	Q6ZMI0	KLRAQ_HUMAN	KLRAQ motif containing 1 isoform 1	301										ovary(1)	1						GTTTAGTTCTCACAATACCTT	0.363													0	0	0	0.054565	0	31	29										T	48698230	C	T	48698230	3	4	122	1	0	0	0	0	1	0	0	0	8413	838	29	1	940	1	KLRAQ1	2	48698230	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	5245399	48698230	194501143	19	36613										
ASB3	51130	broad.mit.edu	37	chr2	53897698	53897698	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	acatcctcagaacgtcttcaTagagcaaataattatgtagg	7	8	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:53897698T>C	uc002rxg.1	-	10	1634	c.1499A>G	c.(1498-1500)TAT>TGT	p.Y500C	ASB3_uc002rxh.1_Missense_Mutation_p.Y427C|ASB3_uc002rxi.3_Missense_Mutation_p.Y538C|ASB3_uc002rxf.1_RNA	NM_016115	NP_057199	Q9Y575	ASB3_HUMAN	ankyrin repeat and SOCS box-containing protein 3	500	SOCS box.				intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AACGTCTTCATAGAGCAAATA	0.388													0	0	0	0.080935	0	11	35										C	53897698	T	C	53897698	3	2	122	1	0	0	0	0	1	0	0	0	1024	1406	49	5	61	5	ASB3	2	53897698	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	5199468	53897698	189301675	20	36614										
ALMS1	7840	broad.mit.edu	37	chr2	73717138	73717138	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccttggctgtcagaattagtAgaacctgcttttgtgccacc	9	11	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:73717138A>G	uc002sje.1	+	12	8166	c.8055A>G	c.(8053-8055)GTA>GTG	p.V2685V	ALMS1_uc002sjf.1_Silent_p.V2641V|ALMS1_uc002sjg.2_Silent_p.V2071V|ALMS1_uc002sjh.1_Silent_p.V2071V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2683					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CAGAATTAGTAGAACCTGCTT	0.398													0	0	0	0.048971	0	173	126										G	73717138	A	G	73717138	2	3	122	1	0	0	0	0	0	0	0	1	535	407	15	5		5	ALMS1	2	73717138	Silent	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	19819440	73717138	169482235	21	36615										
GPAT2	150763	broad.mit.edu	37	chr2	96690055	96690055	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	agggcccctggggcggcactCtgcctgccagcagcccccgc	14	19	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:96690055C>T	uc002svf.2	-	16	1923	c.1700G>A	c.(1699-1701)AGA>AAA	p.R567K	GPAT2_uc002svd.2_Missense_Mutation_p.R386K|GPAT2_uc002sve.2_Missense_Mutation_p.R369K|GPAT2_uc002svg.2_Missense_Mutation_p.R446K|GPAT2_uc010yuh.1_Missense_Mutation_p.R496K|GPAT2_uc002svh.2_Missense_Mutation_p.R567K	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	567					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GGGCGGCACTCTGCCTGCCAG	0.642													0	0	0	0.050027	0	25	23										T	96690055	C	T	96690055	3	4	122	1	0	0	0	0	1	0	0	0	6589	913	32	1	715	1	GPAT2	2	96690055	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	22972917	96690055	146509318	22	36616										
GLI2	2736	broad.mit.edu	37	chr2	121708927	121708927	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttcaacgccccccacccgtaCgtgaacccccacatggagca	7	19	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:121708927C>G	uc010flp.2	+	3	393	c.363C>G	c.(361-363)TAC>TAG	p.Y121*	GLI2_uc010yyu.1_Nonsense_Mutation_p.Y121*|GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Intron|GLI2_uc010flo.1_5'UTR|GLI2_uc002tmw.1_Nonsense_Mutation_p.Y121*	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	121					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CCCACCCGTACGTGAACCCCC	0.657													0	0	0	0.038147	0	8	84										G	121708927	C	G	121708927	4	3	122	1	0	0	0	0	0	1	0	0	6438	547	19	4	373	4	GLI2	2	121708927	Nonsense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	25018872	121708927	121490446	23	36617										
ZRANB3	84083	broad.mit.edu	37	chr2	136107676	136107676	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttcatgtagtgtgattcatCcactataactactttgaagt	6	7	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:136107676C>G	uc002tum.2	-	5	586	c.469G>C	c.(469-471)GAT>CAT	p.D157H	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.D157H|ZRANB3_uc002tun.1_Missense_Mutation_p.D97H	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	157	DEAH box.|Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		TGTGATTCATCCACTATAACT	0.408													0	0	0	0.080935	0	12	14										G	136107676	C	G	136107676	3	3	122	1	0	0	0	0	1	0	0	0	18221	855	30	1	2838	1	ZRANB3	2	136107676	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	14398749	136107676	107091697	24	36618										
TTN	7273	broad.mit.edu	37	chr2	179610937	179610937	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgactgaacatttgaatacaGcatctgaattttctggaatt	7	6	2	4			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:179610937G>A	uc002unb.2	-	46	16414	c.16190C>T	c.(16189-16191)GCT>GTT	p.A5397V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8905							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGAATACAGCATCTGAATT	0.328													0	0	0	0.069288	0	23	30										A	179610937	G	A	179610937	3	1	122	1	0	0	0	0	1	0	0	0	16732	971	34	2	94107	2	TTN	2	179610937	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	43503261	179610937	63588436	25	36619										
FARSB	10056	broad.mit.edu	37	chr2	223436667	223436667	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttggtgataacgtcaggatGaaggaccccaagcttcccga	11	10	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:223436667G>A	uc002vne.1	-	17	1728	c.1693C>T	c.(1693-1695)CAT>TAT	p.H565Y	FARSB_uc010zlq.1_Missense_Mutation_p.H585Y|FARSB_uc002vnf.1_Missense_Mutation_p.H466Y	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	565					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	ACGTCAGGATGAAGGACCCCA	0.488													0	0	0	0.069288	0	21	17										A	223436667	G	A	223436667	3	1	122	1	0	0	0	0	1	0	0	0	5680	1290	45	1	80	1	FARSB	2	223436667	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	43825730	223436667	19762706	26	36620										
HDAC4	9759	broad.mit.edu	37	chr2	240061422	240061422	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcgggcgcgataccgttctcCgcgctgacgctcccggagct	14	16	1	1	rs138989369	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:240061422C>T	uc002vyk.3	-	9	1728	c.936G>A	c.(934-936)GCG>GCA	p.A312A	HDAC4_uc010fyz.1_Silent_p.A307A|HDAC4_uc010zoa.1_Silent_p.A307A|HDAC4_uc010fza.2_Silent_p.A312A|HDAC4_uc010fyy.2_Silent_p.A264A|HDAC4_uc010znz.1_Silent_p.A195A|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	312	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		TACCGTTCTCCGCGCTGACGC	0.662													0	0	0	0.09319	0	11	124										T	240061422	C	T	240061422	2	4	122	1	0	0	0	0	0	0	0	1	7009	639	23	2		2	HDAC4	2	240061422	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	16624755	240061422	3137951	27	36621										
PASK	23178	broad.mit.edu	37	chr2	242065894	242065894	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cccacacagctctcccggaaCcgtcggccttggccaaggtc	10	18	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr2:242065894C>T	uc002wao.1	-	10	2528	c.2436G>A	c.(2434-2436)CGG>CGA	p.R812R	PASK_uc010zol.1_Silent_p.R626R|PASK_uc010zom.1_Silent_p.R777R|PASK_uc010fzl.1_Silent_p.R812R|PASK_uc010zon.1_Silent_p.R593R|PASK_uc002wap.2_Silent_p.R355R|PASK_uc002waq.2_Silent_p.R812R	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	812					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TCTCCCGGAACCGTCGGCCTT	0.562													0	0	0	0.041601	0	31	33										T	242065894	C	T	242065894	2	4	122	1	0	0	0	0	0	0	0	1	11472	494	18	2		2	PASK	2	242065894	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	2004472	242065894	1133479	28	36622										
LRRN1	57633	broad.mit.edu	37	chr3	3887651	3887651	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aacgtggatatcggcacgacGgttttcctagactgtcgagc	12	10	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:3887651G>A	uc003bpt.3	+	2	2087	c.1326G>A	c.(1324-1326)ACG>ACA	p.T442T	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	442	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCGGCACGACGGTTTTCCTAG	0.448													0	0	0	0.045705	0	31	102										A	3887651	G	A	3887651	2	1	122	1	0	0	0	0	0	0	0	1	9034	1103	39	2		2	LRRN1	3	3887651	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		3887651	194134779	29	36623										
ATG7	10533	broad.mit.edu	37	chr3	11340868	11340868	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggctgccagctcgcttaacaTtggagttcagtgcttttgac	11	10	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:11340868T>C	uc003bwc.2	+	3	310	c.193T>C	c.(193-195)TTG>CTG	p.L65L	ATG7_uc003bwd.2_Silent_p.L65L|ATG7_uc011aum.1_Silent_p.L65L	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	65					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						TCGCTTAACATTGGAGTTCAG	0.393													0	0	0	0.048971	0	50	147										C	11340868	T	C	11340868	2	2	122	1	0	0	0	0	0	0	0	1	1101	1490	52	5		5	ATG7	3	11340868	Silent	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	7453217	11340868	186681562	30	36624										
LRRFIP2	9209	broad.mit.edu	37	chr3	37125241	37125241	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttgttcttctcattgtctaaCtgtgcattggaaaccatggc	8	9	3	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:37125241C>A	uc003cgp.2	-	20	1587	c.1164G>T	c.(1162-1164)CAG>CAT	p.Q388H	LRRFIP2_uc011ayf.1_Missense_Mutation_p.Q204H|LRRFIP2_uc003cgr.2_Missense_Mutation_p.Q156H|LRRFIP2_uc003cgs.3_Missense_Mutation_p.Q156H|LRRFIP2_uc003cgt.3_Missense_Mutation_p.Q132H	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	388	Potential.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						CATTGTCTAACTGTGCATTGG	0.348													1	0	2.4624e-09	0.049695	2.53377e-09	19	74										A	37125241	C	A	37125241	3	1	122	1	0	0	0	0	1	0	0	0	9028	564	20	4	1041	4	LRRFIP2	3	37125241	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	25784373	37125241	160897189	31	36625										
GOLGA4	2803	broad.mit.edu	37	chr3	37336557	37336557	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aagatcagtatatcagtgttCtccaaactcaggtaaaagag	8	7	4	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:37336557C>G	uc003cgv.2	+	6	974	c.670C>G	c.(670-672)CTC>GTC	p.L224V	GOLGA4_uc010hgr.1_Intron|GOLGA4_uc003cgw.2_Missense_Mutation_p.L246V|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.L105V	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	224	Potential.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TATCAGTGTTCTCCAAACTCA	0.363													0	0	0	0.064281	0	36	85										G	37336557	C	G	37336557	3	3	122	1	0	0	0	0	1	0	0	0	6555	913	32	1	762	1	GOLGA4	3	37336557	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	211316	37336557	160685873	32	36626										
ARIH2	10425	broad.mit.edu	37	chr3	49005998	49005998	+	Frame_Shift_Del	DEL	C	C	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atggctcaggactgtccactCcgtacaccagaggactttgt							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:49005998delC	uc003cvb.2	+	7	882	c.570delC	c.(568-570)CTCfs	p.L190fs	ARIH2_uc003cvc.2_Frame_Shift_Del_p.L190fs|ARIH2_uc003cvf.2_Frame_Shift_Del_p.L108fs|ARIH2_uc010hkl.2_Frame_Shift_Del_p.L190fs	NM_006321	NP_006312	O95376	ARI2_HUMAN	ariadne homolog 2	190					developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		ACTGTCCACTCCGTACACCAG	0.378																		151	155	---	---								-	49005998	C	-	49005998	7	5	122	1	0	1	0	1	0	0	0	0	924	842	30	0	588	0	ARIH2	3	49005998	Frame_Shift_Del	DEL	C	TCGA-GV-A3QK-01B-11D-A23M-08	11669441	49005998	149016432	33	36627										
GRM2	2912	broad.mit.edu	37	chr3	51743211	51743211	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	catgctttttgcactggaccGcatcaaccgtgacccgcacc	8	16	1	1	rs144180122	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:51743211G>A	uc010hlv.2	+	2	451	c.212G>A	c.(211-213)CGC>CAC	p.R71H	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	71	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCACTGGACCGCATCAACCGT	0.632													0	0	0	0.048971	0	52	202										A	51743211	G	A	51743211	3	1	122	1	0	0	0	0	1	0	0	0	6797	1087	38	2	214	2	GRM2	3	51743211	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	2737213	51743211	146279219	34	36628										
ERC2	26059	broad.mit.edu	37	chr3	56468686	56468686	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcccaccatgttgatctgtgTatgaaaggacatctgtgtgg	12	8	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:56468686T>C	uc003dhr.1	-	2	606	c.350A>G	c.(349-351)TAC>TGC	p.Y117C		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	117						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TTGATCTGTGTATGAAAGGAC	0.507													0	0	0	0.048971	0	69	174										C	56468686	T	C	56468686	3	2	122	1	0	0	0	0	1	0	0	0	5211	1638	57	5	2577	5	ERC2	3	56468686	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	4725475	56468686	141553744	35	36629										
MGLL	11343	broad.mit.edu	37	chr3	127439916	127439916	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cttgaaagttgttgcagattCaggattggcaagaaccagag	12	6	1	4			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:127439916C>G	uc003ejx.2	-	5	605	c.460G>C	c.(460-462)GAA>CAA	p.E154Q	MGLL_uc003ejw.2_Missense_Mutation_p.E164Q|MGLL_uc011bko.1_Missense_Mutation_p.E164Q|MGLL_uc010hsp.1_Missense_Mutation_p.E154Q|MGLL_uc003ejv.2_Missense_Mutation_p.E128Q	NM_001003794	NP_001003794	Q99685	MGLL_HUMAN	monoglyceride lipase isoform 2	154					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity				0						GTTGCAGATTCAGGATTGGCA	0.537													0	0	0	0.037714	0	26	85										G	127439916	C	G	127439916	3	3	122	1	0	0	0	0	1	0	0	0	9556	835	29	1	467	1	MGLL	3	127439916	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	70971230	127439916	70582514	36	36630										
ECE2	9718	broad.mit.edu	37	chr3	183995773	183995773	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gacacagcgcttctacctatCttgcctacaggtggagcgca	10	13	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:183995773C>G	uc003fni.3	+	5	931	c.893C>G	c.(892-894)TCT>TGT	p.S298C	ECE2_uc011brg.1_Missense_Mutation_p.S226C|ECE2_uc011brh.1_Missense_Mutation_p.S151C|ECE2_uc003fnl.3_Missense_Mutation_p.S226C|ECE2_uc003fnm.3_Missense_Mutation_p.S180C|ECE2_uc003fnk.3_Missense_Mutation_p.S151C|ECE2_uc011bri.1_Missense_Mutation_p.S213C|ECE2_uc010hxv.2_Translation_Start_Site	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	298	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCTACCTATCTTGCCTACAG	0.562													0	0	0	0.086207	0	40	115										G	183995773	C	G	183995773	3	3	122	1	0	0	0	0	1	0	0	0	4890	913	32	1	1475	1	ECE2	3	183995773	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	56555857	183995773	14026657	37	36631										
ST6GAL1	6480	broad.mit.edu	37	chr3	186760727	186760727	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	caggggccgccagaccctcgGcagtctcagaggcctagcca	13	16	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:186760727G>T	uc003frb.2	+	4	668	c.236G>T	c.(235-237)GGC>GTC	p.G79V	ST6GAL1_uc003frc.2_Intron|ST6GAL1_uc003frd.2_Missense_Mutation_p.G79V	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	79	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CAGACCCTCGGCAGTCTCAGA	0.567													1	0	9.85913e-13	0.11126	1.02439e-12	43	137										T	186760727	G	T	186760727	3	4	122	1	0	0	0	0	1	0	0	0	15220	1203	42	4	238	4	ST6GAL1	3	186760727	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	2764954	186760727	11261703	38	36632										
LMLN	89782	broad.mit.edu	37	chr3	197726164	197726164	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cgatgactggttctcacactCagaatcgagtactctctcga	8	12	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr3:197726164C>G	uc011buo.1	+	11	1205	c.1183C>G	c.(1183-1185)CAG>GAG	p.Q395E	LMLN_uc003fyt.2_Missense_Mutation_p.Q343E|LMLN_uc010iar.2_Missense_Mutation_p.Q395E|LMLN_uc010ias.2_Missense_Mutation_p.Q343E|LMLN_uc003fyu.2_Missense_Mutation_p.Q155E	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	395					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		TTCTCACACTCAGAATCGAGT	0.388													0	0	0	0.043863	0	17	58										G	197726164	C	G	197726164	3	3	122	1	0	0	0	0	1	0	0	0	8847	827	29	1	1225	1	LMLN	3	197726164	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	10965437	197726164	296266	39	36633										
RNF212	285498	broad.mit.edu	37	chr4	1107304	1107304	+	Translation_Start_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcccacgcgaagcccacgcaAggttgggaccagcctccccg	12	18	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:1107304A>T	uc003gcj.2	-	1	279	c.-51T>A	c.(-53--49)CCTTG>CCATG		RNF212_uc003gci.2_Translation_Start_Site|RNF212_uc010ibp.2_RNA|RNF212_uc010ibq.2_Translation_Start_Site|RNF212_uc003gck.2_Translation_Start_Site	NM_001131034	NP_001124506	Q495C1	RN212_HUMAN	ring finger protein 212 isoform a								zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (64;0.151)		AGCCCACGCAAGGTTGGGACC	0.736													0	0	0	0.080935	0	10	17										T	1107304	A	T	1107304	1	4	122	1	0	0	0	0	0	0	0	0	13476	87	3	5		5	RNF212	4	1107304	Translation_Start_Site	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08		1107304	190046972	40	36634										
KIAA0232	9778	broad.mit.edu	37	chr4	6862671	6862671	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttctgagaaaccagtttgcCtgcaagaaatcatgactgtg	9	8	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:6862671C>G	uc003gjr.3	+	7	1025	c.562C>G	c.(562-564)CTG>GTG	p.L188V	KIAA0232_uc003gjq.3_Missense_Mutation_p.L188V	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	188							ATP binding			ovary(2)	2						ACCAGTTTGCCTGCAAGAAAT	0.408													0	0	0	0.048971	0	50	97										G	6862671	C	G	6862671	3	3	122	1	0	0	0	0	1	0	0	0	8163	680	24	4	580	4	KIAA0232	4	6862671	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	5755367	6862671	184291605	41	36635										
CC2D2A	57545	broad.mit.edu	37	chr4	15542459	15542459	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gtgaatggtctccttttgcaGagcggaggtctcgagaaggg	16	7	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:15542459G>A	uc010idv.2	+	18	2249	c.2004_splice	c.e18-1	p.R668_splice	CC2D2A_uc003gnx.2_Splice_Site_p.R619_splice|CC2D2A_uc003gnz.1_Splice_Site|CC2D2A_uc003goa.1_Splice_Site	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform						cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						TCCTTTTGCAGAGCGGAGGTC	0.433													0	0	0	0.004672	0	3	10										A	15542459	G	A	15542459	5	1	122	1	0	0	0	0	0	0	1	0	2728	956	33	1	2268	1	CC2D2A	4	15542459	Splice_Site	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	8679788	15542459	175611817	42	36636										
UCHL1	7345	broad.mit.edu	37	chr4	41263746	41263746	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttaagaggatggatcagttCtgaaacagtttctttctgaa	9	5	4	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:41263746C>T	uc003gvo.2	+	5	436	c.340C>T	c.(340-342)CTG>TTG	p.L114L	UCHL1_uc003gvp.2_Silent_p.L33L|UCHL1_uc003gvq.2_Silent_p.L33L|UCHL1_uc003gvr.2_Silent_p.L33L|UCHL1_uc003gvs.2_Silent_p.L33L	NM_004181	NP_004172	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1	114					cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|skin(1)	2						TGGATCAGTTCTGAAACAGTT	0.343													0	0	0	0.038395	0	18	41										T	41263746	C	T	41263746	2	4	122	1	0	0	0	0	0	0	0	1	16917	912	32	1		1	UCHL1	4	41263746	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	25721287	41263746	149890530	43	36637										
LPHN3	23284	broad.mit.edu	37	chr4	62813863	62813863	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	actgttcattttggagctacTccaagcgtacaatgacaggt	9	9	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:62813863T>C	uc010ihh.2	+	14	2643	c.2470T>C	c.(2470-2472)TCC>CCC	p.S824P	LPHN3_uc003hcq.3_Missense_Mutation_p.S824P|LPHN3_uc003hct.2_Missense_Mutation_p.S217P	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	811	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TTGGAGCTACTCCAAGCGTAC	0.373													0	0	0	0.02938	0	6	15										C	62813863	T	C	62813863	3	2	122	1	0	0	0	0	1	0	0	0	8917	1551	54	5	2524	5	LPHN3	4	62813863	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	21550117	62813863	128340413	44	36638										
SHROOM3	57619	broad.mit.edu	37	chr4	77357255	77357255	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcctagtgccacattaaactCtaacacggccaccaagggaa	8	13	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:77357255C>G	uc011cbx.1	+	1	1003	c.50C>G	c.(49-51)TCT>TGT	p.S17C		NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	17					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			ACATTAAACTCTAACACGGCC	0.483													0	0	0	0.048971	0	66	131										G	77357255	C	G	77357255	3	3	122	1	0	0	0	0	1	0	0	0	14295	913	32	1	52	1	SHROOM3	4	77357255	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	14543392	77357255	113797021	45	36639										
ATOH1	474	broad.mit.edu	37	chr4	94750250	94750250	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgagctgtccctcctggacaGcaccgacccacgcgcctggc	11	18	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr4:94750250G>T	uc003hta.1	+	1	173	c.173G>T	c.(172-174)AGC>ATC	p.S58I		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	58					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CTCCTGGACAGCACCGACCCA	0.677													1	0	1.16021e-09	0.034045	1.19963e-09	27	47										T	94750250	G	T	94750250	3	4	122	1	0	0	0	0	1	0	0	0	1112	971	34	4	175	4	ATOH1	4	94750250	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	17392995	94750250	96404026	46	36640										
ADCY2	108	broad.mit.edu	37	chr5	7695949	7695949	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gtccacatgctgaatgagctCtttggaaagtttgatcaaat	9	7	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:7695949C>G	uc003jdz.1	+	6	1021	c.954C>G	c.(952-954)CTC>CTG	p.L318L	ADCY2_uc011cmo.1_Silent_p.L138L	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	318	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TGAATGAGCTCTTTGGAAAGT	0.433													0	0	0	0.0333	0	14	33										G	7695949	C	G	7695949	2	3	122	1	0	0	0	0	0	0	0	1	294	900	32	1		1	ADCY2	5	7695949	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		7695949	173219311	47	36641										
MARCH11	441061	broad.mit.edu	37	chr5	16067768	16067768	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tggcaaccacaaagtcctacTtgtggaagactctccccggc	9	14	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:16067768T>C	uc003jfo.2	-	4	1234	c.1021A>G	c.(1021-1023)AGT>GGT	p.S341G	MARCH11_uc010itw.1_Missense_Mutation_p.S97G	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	341						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AAAGTCCTACTTGTGGAAGAC	0.473													0	0	0	0.108266	0	28	62										C	16067768	T	C	16067768	3	2	122	1	0	0	0	0	1	0	0	0	9300	1609	56	5	191	5	MARCH11	5	16067768	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	8371819	16067768	164847492	48	36642										
BASP1	10409	broad.mit.edu	37	chr5	17275799	17275799	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gaggcgcccgcagctcctgcCgcccaggagaccaaaagtga	13	15	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:17275799C>T	uc003jfx.2	+	2	653	c.474C>T	c.(472-474)GCC>GCT	p.A158A		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	158					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						CAGCTCCTGCCGCCCAGGAGA	0.517													0	0	0	0.02938	0	6	15										T	17275799	C	T	17275799	2	4	122	1	0	0	0	0	0	0	0	1	1317	639	23	2		2	BASP1	5	17275799	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	1208031	17275799	163639461	49	36643										
ANKRD55	79722	broad.mit.edu	37	chr5	55407474	55407475	+	Missense_Mutation	DNP	CC	CC	AA													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tcctcctctctgtatcggtcCctgctgggatccttctgatg							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:55407474_55407475CC>AA	uc003jqu.2	-	10	1252_1253	c.1100_1101GG>TT	c.(1099-1101)AGG>ATT	p.R367I	ANKRD55_uc003jqt.2_Missense_Mutation_p.R79I	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	366										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TGTATCGGTCCCTGCTGGGATC	0.505													0	0	0	0.004672	0	81	185										AA	55407475	CC	AA	55407474	3	1	122	1	0	0	0	0	1	0	0	0	681	622	22	4	755	4	ANKRD55	5	55407474	Missense_Mutation	DNP	CC	TCGA-GV-A3QK-01B-11D-A23M-08	38131675	55407474	125507786	50	36644										
ZNF608	57507	broad.mit.edu	37	chr5	123983602	123983602	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atttttgggcttcccgtctcTttcccttctttgtcctttag	6	12	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:123983602T>C	uc003ktq.1	-	4	2598	c.2475A>G	c.(2473-2475)AAA>AAG	p.K825K	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Silent_p.K825K|ZNF608_uc003ktt.1_Silent_p.K825K	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	825						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TTCCCGTCTCTTTCCCTTCTT	0.473													0	0	0	0.048971	0	76	174										C	123983602	T	C	123983602	2	2	122	1	0	0	0	0	0	0	0	1	18031	1606	56	5		5	ZNF608	5	123983602	Silent	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	68576128	123983602	56931658	51	36645										
FBN2	2201	broad.mit.edu	37	chr5	127674667	127674667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gaagccactttcatagccttCgaagcactcgcactcaaagc	7	14	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:127674667C>T	uc003kuu.2	-	26	3869	c.3430G>A	c.(3430-3432)GAA>AAA	p.E1144K	FBN2_uc003kuv.2_Missense_Mutation_p.E1111K	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1144	EGF-like 16; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATAGCCTTCGAAGCACTCG	0.507													0	0	0	0.054565	0	32	84										T	127674667	C	T	127674667	3	4	122	1	0	0	0	0	1	0	0	0	5703	893	31	1	5468	1	FBN2	5	127674667	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	3691065	127674667	53240593	52	36646										
REEP2	51308	broad.mit.edu	37	chr5	137777134	137777134	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccacggccgagacgctcacgGatatagtgctctcctggtga	12	13	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:137777134G>A	uc003lcz.2	+	3	288	c.166G>A	c.(166-168)GAT>AAT	p.D56N	REEP2_uc003lda.2_Missense_Mutation_p.D56N|REEP2_uc011cyt.1_Missense_Mutation_p.D17N	NM_016606	NP_057690	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	56						integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GACGCTCACGGATATAGTGCT	0.602													0	0	0	0.050027	0	29	57										A	137777134	G	A	137777134	3	1	122	1	0	0	0	0	1	0	0	0	13205	1174	41	1	176	1	REEP2	5	137777134	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	10102467	137777134	43138126	53	36647										
PCDHA4	56144	broad.mit.edu	37	chr5	140188665	140188665	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gggctgtacactggcgagatCagcacaacgcgtgccctgga	14	12	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:140188665C>T	uc003lhi.2	+	1	1994	c.1893C>T	c.(1891-1893)ATC>ATT	p.I631I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.I631I|PCDHA4_uc011daa.1_Silent_p.I631I	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	631	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCGAGATCAGCACAACGC	0.682													0	0	0	0.048971	0	59	132										T	140188665	C	T	140188665	2	4	122	1	0	0	0	0	0	0	0	1	11526	816	29	1		1	PCDHA4	5	140188665	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	2411531	140188665	40726595	54	36648										
PCDHGB1	56104	broad.mit.edu	37	chr5	140730728	140730728	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctggcgacatcacaaccaatGgcacattggattttgaagag	10	9	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr5:140730728G>A	uc003ljo.1	+	1	901	c.901G>A	c.(901-903)GGC>AGC	p.G301S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.G301S	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	301	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAACCAATGGCACATTGGA	0.418													0	0	0	0.048971	0	47	97										A	140730728	G	A	140730728	3	1	122	1	0	0	0	0	1	0	0	0	11562	1348	47	2	903	2	PCDHGB1	5	140730728	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	542063	140730728	40184532	55	36649										
FOXC1	2296	broad.mit.edu	37	chr6	1612318	1612318	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	taccgcacgtccggagctttCgtctacgactgtagcaagtt	10	12	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:1612318C>T	uc003mtp.2	+	1	1638	c.1638C>T	c.(1636-1638)TTC>TTT	p.F546F		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	546					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		CCGGAGCTTTCGTCTACGACT	0.498													0	0	0	0.105934	0	14	21										T	1612318	C	T	1612318	2	4	122	1	0	0	0	0	0	0	0	1	5994	883	31	1		1	FOXC1	6	1612318	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		1612318	169502749	56	36650										
HLA-DMB	3109	broad.mit.edu	37	chr6	32906580	32906580	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggtgctgtgagaggacattcGccaagctattcagcacccca	11	12	1	1	rs12176347		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:32906580G>A	uc003ocl.1	-	2	451	c.218C>T	c.(217-219)GCG>GTG	p.A73V	HLA-DMB_uc003ocj.1_Missense_Mutation_p.A73V|HLA-DMB_uc003ock.1_5'Flank|HLA-DMB_uc010jud.1_5'Flank|HLA-DMB_uc010jue.1_5'Flank|HLA-DMB_uc010juf.1_5'Flank|HLA-DMB_uc011dql.1_Missense_Mutation_p.A73V	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	73	Beta-1.|Lumenal (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						GAGGACATTCGCCAAGCTATT	0.527													0	0	0	0.045515	0	47	80										A	32906580	G	A	32906580	3	1	122	1	0	0	0	0	1	0	0	0	7199	1087	38	2	593	2	HLA-DMB	6	32906580	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	31294262	32906580	138208487	57	36651										
TRERF1	55809	broad.mit.edu	37	chr6	42196333	42196333	+	Frame_Shift_Del	DEL	T	T	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	caaaagccgccttctgagccTtttgcctctgttgttcctcc							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:42196333delT	uc003osd.2	-	18	3916	c.3353delA	c.(3352-3354)AAGfs	p.K1118fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.K1035fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.K886fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.K874fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.K1138fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542																		8	554	---	---								-	42196333	T	-	42196333	7	5	122	1	0	1	0	1	0	0	0	0	16472	1609	56	0	253	0	TRERF1	6	42196333	Frame_Shift_Del	DEL	T	TCGA-GV-A3QK-01B-11D-A23M-08	9289753	42196333	128918734	58	36652										
RWDD2A	112611	broad.mit.edu	37	chr6	83905938	83905938	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttctcaagaagcacaaaagtGagcatgtttttcagatacta	7	7	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:83905938G>C	uc003pjx.3	+	3	1097	c.826G>C	c.(826-828)GAG>CAG	p.E276Q	PGM3_uc011dyz.1_5'Flank|RWDD2A_uc011dza.1_Missense_Mutation_p.E201Q	NM_033411	NP_219479	Q9UIY3	RWD2A_HUMAN	RWD domain containing 2A	276											0		all_cancers(76;2.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00217)		BRCA - Breast invasive adenocarcinoma(397;0.045)		GCACAAAAGTGAGCATGTTTT	0.363													0	0	0	0.069288	0	23	55										C	83905938	G	C	83905938	3	2	122	1	0	0	0	0	1	0	0	0	13755	1291	45	1	832	1	RWDD2A	6	83905938	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	41709605	83905938	87209129	59	36653										
PRSS35	167681	broad.mit.edu	37	chr6	84234199	84234199	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atgctgagtcgggctccaccGgttcgggggtctatctgcgt	15	11	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:84234199G>A	uc003pjz.2	+	2	1202	c.1039G>A	c.(1039-1041)GGT>AGT	p.G347S	PRSS35_uc010kbm.2_Missense_Mutation_p.G347S	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	347	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		GGGCTCCACCGGTTCGGGGGT	0.512													0	0	0	0.048971	0	52	72										A	84234199	G	A	84234199	3	1	122	1	0	0	0	0	1	0	0	0	12624	1116	39	2	1041	2	PRSS35	6	84234199	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	328261	84234199	86880868	60	36654										
SFRS18	25957	broad.mit.edu	37	chr6	99848724	99848724	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tctatcatcctgactactgaActtaaaatctttttcttccc	2	12	4	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:99848724A>G	uc003ppo.3	-	12	2338	c.2110T>C	c.(2110-2112)TTC>CTC	p.F704L	SFRS18_uc003ppl.2_Missense_Mutation_p.F250L|SFRS18_uc003ppp.3_Missense_Mutation_p.F704L|SFRS18_uc011eag.1_Missense_Mutation_p.F704L	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	704						nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TGACTACTGAACTTAAAATCt	0.169													0	0	0	0.105934	0	14	29										G	99848724	A	G	99848724	3	3	122	1	0	0	0	0	1	0	0	0	14174	43	2	5	311	5	SFRS18	6	99848724	Missense_Mutation	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	15614525	99848724	71266343	61	36655										
LAMA2	3908	broad.mit.edu	37	chr6	129794495	129794495	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctgccaacgctgagaaacttGaggtaatttagtttatatgt	9	6	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:129794495G>C	uc003qbn.2	+	51	7542	c.7437G>C	c.(7435-7437)TTG>TTC	p.L2479F	LAMA2_uc003qbo.2_Missense_Mutation_p.L2479F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2479	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGAGAAACTTGAGGTAATTTA	0.333													0	0	0	0.099896	0	26	48										C	129794495	G	C	129794495	3	2	122	1	0	0	0	0	1	0	0	0	8606	1281	45	1	7643	1	LAMA2	6	129794495	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	29945771	129794495	41320572	62	36656										
OLIG3	167826	broad.mit.edu	37	chr6	137815072	137815072	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcctcaactgctgtaggtccTgctccgacagctgcttcttg	10	14	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr6:137815072T>A	uc003qhp.1	-	1	460	c.236A>T	c.(235-237)CAG>CTG	p.Q79L		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	79	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		CTGTAGGTCCTGCTCCGACAG	0.597													0	0	0	0.048971	0	63	120										A	137815072	T	A	137815072	3	1	122	1	0	0	0	0	1	0	0	0	10862	1580	55	5	586	5	OLIG3	6	137815072	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	8020577	137815072	33299995	63	36657										
TWISTNB	221830	broad.mit.edu	37	chr7	19738064	19738064	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	actttggtaaccactggagtCactgccttggaaaacagggt	11	9	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:19738064C>T	uc003sup.1	-	4	913	c.892G>A	c.(892-894)GAC>AAC	p.D298N		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	298	Lys-rich.					microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						CCACTGGAGTCACTGCCTTGG	0.423													0	0	0	0.048971	0	208	207										T	19738064	C	T	19738064	3	4	122	1	0	0	0	0	1	0	0	0	16781	826	29	1	128	1	TWISTNB	7	19738064	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		19738064	139400599	64	36658										
DNAH11	8701	broad.mit.edu	37	chr7	21857887	21857887	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttggtgatgtcatcttaattGaaaatctcgaggaaacgata	9	5	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:21857887G>A	uc003svc.2	+	66	10673	c.10642G>A	c.(10642-10644)GAA>AAA	p.E3548K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3548	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CATCTTAATTGAAAATCTCGA	0.328									Kartagener_syndrome				0	0	0	0.104719	0	38	22										A	21857887	G	A	21857887	3	1	122	1	0	0	0	0	1	0	0	0	4599	1291	45	1	10901	1	DNAH11	7	21857887	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	2119823	21857887	137280776	65	36659										
AMPH	273	broad.mit.edu	37	chr7	38475976	38475976	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	agtctcctctttcttcacctCagggacttcattctgttaaa	5	12	7	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:38475976C>T	uc003tgu.2	-	12	1099	c.1030G>A	c.(1030-1032)GAG>AAG	p.E344K	AMPH_uc003tgv.2_Missense_Mutation_p.E344K|AMPH_uc003tgt.2_Missense_Mutation_p.E97K	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	344					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TTCTTCACCTCAGGGACTTCA	0.428													0	0	0	0.050027	0	32	33										T	38475976	C	T	38475976	3	4	122	1	0	0	0	0	1	0	0	0	588	835	29	1	1097	1	AMPH	7	38475976	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	16618089	38475976	120662687	66	36660										
GRB10	2887	broad.mit.edu	37	chr7	50663213	50663213	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttggattactctggctgtcaCggaggagaaaaagcctgggg	15	7	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:50663213C>A	uc003tpi.2	-	15	1590	c.1559G>T	c.(1558-1560)CGT>CTT	p.R520L	GRB10_uc003tph.3_Missense_Mutation_p.R462L|GRB10_uc003tpj.2_Missense_Mutation_p.R474L|GRB10_uc003tpk.2_Missense_Mutation_p.R520L|GRB10_uc010kzb.2_Missense_Mutation_p.R462L|GRB10_uc003tpl.2_Missense_Mutation_p.R514L|GRB10_uc003tpm.2_Missense_Mutation_p.R462L|GRB10_uc003tpn.2_Missense_Mutation_p.R462L	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	520	SH2.			R->K: No effect on NEDD4-binding. No effect on the disruption of the interaction between INSR and IRS1 and IRS2.	insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity	p.R520H(1)		lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					CTGGCTGTCACGGAGGAGAAA	0.303									Russell-Silver_syndrome				1	0	6.95862e-65	0.048971	7.71972e-65	137	152										A	50663213	C	A	50663213	3	1	122	1	0	0	0	0	1	0	0	0	6756	536	19	4	233	4	GRB10	7	50663213	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	12187237	50663213	108475450	67	36661										
GIGYF1	64599	broad.mit.edu	37	chr7	100283947	100283948	+	Frame_Shift_Ins	INS	-	-	C													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggtgagagctgcctccccctINSccccgcccctcctcttcacc							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:100283947_100283948insC	uc003uwg.1	-	8	1812_1813	c.803_804insG	c.(802-804)GGAfs	p.G268fs		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	268	Poly-Gly.									large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGCCTCCCCCTCCCCGCCCCTC	0.644																		7	186	---	---								C	100283948	-	C	100283947	7	5	122	1	0	1	1	0	0	0	0	0	6377	1538	54	0	2371	0	GIGYF1	7	100283947	Frame_Shift_Ins	INS	-	TCGA-GV-A3QK-01B-11D-A23M-08	49620734	100283947	58854716	68	36662										
MUC17	140453	broad.mit.edu	37	chr7	100681563	100681563	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aagtatacctgtcagccacaCgctggtggccaattctgagg	11	11	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:100681563C>T	uc003uxp.1	+	3	6919	c.6866C>T	c.(6865-6867)ACG>ATG	p.T2289M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2289	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|36.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCCACACGCTGGTGGCC	0.478													0	0	0	0.048971	0	292	342										T	100681563	C	T	100681563	3	4	122	1	0	0	0	0	1	0	0	0	9974	536	19	2	6876	2	MUC17	7	100681563	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	397616	100681563	58457100	69	36663										
RELN	5649	broad.mit.edu	37	chr7	103368593	103368593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atatggttcacagaaggtgaCggcattgccatgcataatcg	11	8	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:103368593C>T	uc003vca.2	-	7	878	c.718G>A	c.(718-720)GTC>ATC	p.V240I	RELN_uc010liz.2_Missense_Mutation_p.V240I	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	240					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGAAGGTGACGGCATTGCCA	0.433													0	0	0	0.048971	0	50	59										T	103368593	C	T	103368593	3	4	122	1	0	0	0	0	1	0	0	0	13220	536	19	2	9900	2	RELN	7	103368593	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	2687030	103368593	55770070	70	36664										
OR2F1	26211	broad.mit.edu	37	chr7	143657782	143657782	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aagaaagaaagctttccacaCgtgtgcctctcacctcacag	7	13	2	2	rs73464588	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:143657782C>A	uc003wds.1	+	1	763	c.719C>A	c.(718-720)ACG>AAG	p.T240K		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					GCTTTCCACACGTGTGCCTCT	0.507													1	0	8.70839e-23	0.048971	9.41567e-23	80	90										A	143657782	C	A	143657782	3	1	122	1	0	0	0	0	1	0	0	0	10996	536	19	4	721	4	OR2F1	7	143657782	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	40289189	143657782	15480881	71	36665										
ZNF862	643641	broad.mit.edu	37	chr7	149558887	149558887	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gccgcgcctacgtggcactgGagagcctccgtcaccaggca	13	16	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:149558887G>A	uc010lpn.2	+	7	2830	c.2638G>A	c.(2638-2640)GAG>AAG	p.E880K	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	880					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						CGTGGCACTGGAGAGCCTCCG	0.602													0	0	0	0.069456	0	39	37										A	149558887	G	A	149558887	3	1	122	1	0	0	0	0	1	0	0	0	18192	1175	41	1	2664	1	ZNF862	7	149558887	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	5901105	149558887	9579776	72	36666										
DPP6	1804	broad.mit.edu	37	chr7	154564587	154564587	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aaccccagcatttccctacaCgttattggcttaaatggacc	6	13	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr7:154564587C>T	uc003wlk.2	+	10	1200	c.1071C>T	c.(1069-1071)CAC>CAT	p.H357H	DPP6_uc003wli.2_Silent_p.H293H|DPP6_uc003wlm.2_Silent_p.H295H|DPP6_uc011kvq.1_Silent_p.H250H	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	357	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TTTCCCTACACGTTATTGGCT	0.453													0	0	0	0.038395	0	17	13										T	154564587	C	T	154564587	2	4	122	1	0	0	0	0	0	0	0	1	4730	535	19	2		2	DPP6	7	154564587	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	5005700	154564587	4574076	73	36667										
MYOM2	9172	broad.mit.edu	37	chr8	2044236	2044236	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttcaccataaaaactggcacGaggtcaattcctcacccagc	6	14	3	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:2044236G>A	uc003wpx.3	+	18	2413	c.2275G>A	c.(2275-2277)GAG>AAG	p.E759K	MYOM2_uc011kwi.1_Missense_Mutation_p.E184K	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	759	Fibronectin type-III 4.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAACTGGCACGAGGTCAATTC	0.493													0	0	0	0.069288	0	23	49										A	2044236	G	A	2044236	3	1	122	1	0	0	0	0	1	0	0	0	10092	1059	37	1	2341	1	MYOM2	8	2044236	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		2044236	144319786	74	36668										
DOCK5	80005	broad.mit.edu	37	chr8	25267711	25267711	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgaaggcagccagaggaactCcactgaggtagggaaatcac	13	9	1	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:25267711C>G	uc003xeg.2	+	51	5638	c.5501C>G	c.(5500-5502)TCC>TGC	p.S1834C	PPP2R2A_uc003xek.2_Intron|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1834	Pro-rich.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CAGAGGAACTCCACTGAGGTA	0.592													0	0	0	0.024245	0	15	29										G	25267711	C	G	25267711	3	3	122	1	0	0	0	0	1	0	0	0	4690	855	30	1	5703	1	DOCK5	8	25267711	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	23223475	25267711	121096311	75	36669										
RB1CC1	9821	broad.mit.edu	37	chr8	53568651	53568651	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctctccaatttaaattctttTagggcagtctgaatagcttc	6	9	3	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:53568651T>C	uc003xre.3	-	15	4296	c.3738A>G	c.(3736-3738)CTA>CTG	p.L1246L	RB1CC1_uc003xrf.3_Silent_p.L1246L	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	1246	Potential.				autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TAAATTCTTTTAGGGCAGTCT	0.328													0	0	0	0.041601	0	30	46										C	53568651	T	C	53568651	2	2	122	1	0	0	0	0	0	0	0	1	13099	1741	61	5		5	RB1CC1	8	53568651	Silent	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	28300940	53568651	92795371	76	36670										
SLCO5A1	81796	broad.mit.edu	37	chr8	70588853	70588853	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cagggacgtaccaagtgttcGcaacaaaacaaactgcattc	8	11	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:70588853G>A	uc003xyl.2	-	9	2787	c.2080C>T	c.(2080-2082)CGA>TGA	p.R694*	SLCO5A1_uc010lzb.2_Nonsense_Mutation_p.R639*|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Intron	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	694	Helical; Name=11; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CCAAGTGTTCGCAACAAAACA	0.418													0	0	0	0.043863	0	20	48										A	70588853	G	A	70588853	4	1	122	1	0	0	0	0	0	1	0	0	14731	1095	38	2	474	2	SLCO5A1	8	70588853	Nonsense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	17020202	70588853	75775169	77	36671										
PDP1	54704	broad.mit.edu	37	chr8	94934630	94934630	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctatccttggatttgacagcAatcagctgcctgcaaatgca	8	11	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:94934630A>G	uc003yge.2	+	2	612	c.343A>G	c.(343-345)AAT>GAT	p.N115D	PDP1_uc003ygf.2_Missense_Mutation_p.N140D|PDP1_uc010max.2_Missense_Mutation_p.N140D|PDP1_uc011lgm.1_Missense_Mutation_p.N115D|PDP1_uc011lgn.1_Missense_Mutation_p.N174D	NM_018444	NP_060914	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic	115				NVSSILGFDSNQ -> MSVLSLDLTAIK (in Ref. 1; AAF67480).	pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						ATTTGACAGCAATCAGCTGCC	0.468													0	0	0	0.104719	0	41	117										G	94934630	A	G	94934630	3	3	122	1	0	0	0	0	1	0	0	0	11685	130	5	5	526	5	PDP1	8	94934630	Missense_Mutation	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	24345777	94934630	51429392	78	36672										
COL22A1	169044	broad.mit.edu	37	chr8	139609214	139609214	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tccatggatggagactccccCtaggagggagggaaggtgga	17	8	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr8:139609214C>T	uc003yvd.2	-	62	4813	c.4366_splice	c.e62-1	p.G1456_splice	COL22A1_uc011ljo.1_Splice_Site_p.G736_splice	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GAGACTCCCCCTAGGAGGGAG	0.507										HNSCC(7;0.00092)			0	0	0	0.11126	0	44	84										T	139609214	C	T	139609214	5	4	122	1	0	0	0	0	0	0	1	0	3681	695	24	2	531	2	COL22A1	8	139609214	Splice_Site	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	44674584	139609214	6754808	79	36673										
ZNF510	22869	broad.mit.edu	37	chr9	99522006	99522006	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atttaacccaagtctgtgttCtgtcattacttaccaatggg	7	9	3	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:99522006C>T	uc004awn.1	-	6	1295	c.1106G>A	c.(1105-1107)AGA>AAA	p.R369K	ZNF510_uc004awo.1_Missense_Mutation_p.R369K	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				AGTCTGTGTTCTGTCATTACT	0.388													0	0	0	0.048971	0	56	41										T	99522006	C	T	99522006	3	4	122	1	0	0	0	0	1	0	0	0	17951	913	32	1	949	1	ZNF510	9	99522006	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		99522006	41691425	80	36674										
HSDL2	84263	broad.mit.edu	37	chr9	115171290	115171290	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atgaacgtgaacaccagaggCacctaccttgcgtaagtttg	10	10	0	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115171290C>T	uc004bga.1	+	4	477	c.384C>T	c.(382-384)GGC>GGT	p.G128G	HSDL2_uc011lwv.1_Silent_p.G7G|HSDL2_uc004bgb.1_Intron|HSDL2_uc004bgc.1_Intron|HSDL2_uc011lww.1_5'UTR	NM_032303	NP_115679	Q6YN16	HSDL2_HUMAN	hydroxysteroid dehydrogenase like 2	128						peroxisome	oxidoreductase activity|sterol binding				0						ACACCAGAGGCACCTACCTTG	0.418													0	0	0	0.050027	0	28	59										T	115171290	C	T	115171290	2	4	122	1	0	0	0	0	0	0	0	1	7394	697	25	2		2	HSDL2	9	115171290	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	15649284	115171290	26042141	81	36675										
ZFP37	7539	broad.mit.edu	37	chr9	115805288	115805288	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gtttctctccagtatgaactCtctgatgttgagtaaggcct	9	9	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115805288C>G	uc004bgm.1	-	4	1638	c.1610G>C	c.(1609-1611)AGA>ACA	p.R537T	ZFP37_uc011lwz.1_Missense_Mutation_p.R552T|ZFP37_uc011lxa.1_Missense_Mutation_p.R538T	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	537	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGTATGAACTCTCTGATGTTG	0.403													0	0	0	0.041601	0	30	47										G	115805288	C	G	115805288	3	3	122	1	0	0	0	0	1	0	0	0	17645	913	32	1	286	1	ZFP37	9	115805288	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	633998	115805288	25408143	82	36676			1	171		4	4	1254	C		5.978854e-08
ZFP37	7539	broad.mit.edu	37	chr9	115805738	115805738	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gaataaggtttgagctgtgtCtgaaggttttcccacattca	10	7	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115805738C>G	uc004bgm.1	-	4	1188	c.1160G>C	c.(1159-1161)AGA>ACA	p.R387T	ZFP37_uc011lwz.1_Missense_Mutation_p.R402T|ZFP37_uc011lxa.1_Missense_Mutation_p.R388T	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	387	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGAGCTGTGTCTGAAGGTTTT	0.413													0	0	0	0.092188	0	41	82										G	115805738	C	G	115805738	3	3	122	1	0	0	0	0	1	0	0	0	17645	913	32	1	736	1	ZFP37	9	115805738	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	450	115805738	25407693	83	36677			1	171		4	4	1254	C		5.978854e-08
ZFP37	7539	broad.mit.edu	37	chr9	115806346	115806346	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggtaaatctaaattctgtttCaaaatttttccacatgactc	4	8	3	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115806346C>T	uc004bgm.1	-	4	580	c.552G>A	c.(550-552)TTG>TTA	p.L184L	ZFP37_uc011lwz.1_Silent_p.L199L|ZFP37_uc011lxa.1_Silent_p.L185L	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AATTCTGTTTCAAAATTTTTC	0.333													0	0	0	0.069456	0	39	63										T	115806346	C	T	115806346	2	4	122	1	0	0	0	0	0	0	0	1	17645	825	29	1		1	ZFP37	9	115806346	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	608	115806346	25407085	84	36678			1	171		4	4	1254	C		5.978854e-08
ZFP37	7539	broad.mit.edu	37	chr9	115806541	115806541	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tcaagctggtcatcatctttCtggacttctaaaatggaatt	7	8	6	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:115806541C>G	uc004bgm.1	-	4	385	c.357G>C	c.(355-357)CAG>CAC	p.Q119H	ZFP37_uc011lwz.1_Missense_Mutation_p.Q134H|ZFP37_uc011lxa.1_Missense_Mutation_p.Q120H	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	119						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CATCATCTTTCTGGACTTCTA	0.353													0	0	0	0.0918	0	26	54										G	115806541	C	G	115806541	3	3	122	1	0	0	0	0	1	0	0	0	17645	912	32	1	1539	1	ZFP37	9	115806541	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	195	115806541	25406890	85	36679			1	171		4	4	1254	C		5.978854e-08
LRSAM1	90678	broad.mit.edu	37	chr9	130217858	130217858	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tctttatcttatcttagattCcatttggagcttttgcaaca	5	8	3	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:130217858C>G	uc004brb.1	+	5	478	c.133C>G	c.(133-135)CCA>GCA	p.P45A	LRSAM1_uc010mxk.1_Missense_Mutation_p.P45A|LRSAM1_uc004brc.1_Missense_Mutation_p.P45A|LRSAM1_uc004brd.1_Missense_Mutation_p.P45A	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	45	LRR 1.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						ATCTTAGATTCCATTTGGAGC	0.438													0	0	0	0.030593	0	29	60										G	130217858	C	G	130217858	3	3	122	1	0	0	0	0	1	0	0	0	9043	855	30	1	143	1	LRSAM1	9	130217858	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	14411317	130217858	10995573	86	36680										
FAM78A	286336	broad.mit.edu	37	chr9	134136337	134136337	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gggctcattcttgctcaggaTtttgggctggtcctgggcga	15	9	3	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:134136337T>G	uc004cak.2	-	2	1064	c.724A>C	c.(724-726)ATC>CTC	p.I242L	FAM78A_uc004caj.2_Missense_Mutation_p.I239L	NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	242										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		TTGCTCAGGATTTTGGGCTGG	0.682													0	0	0	0.048971	0	58	111										G	134136337	T	G	134136337	3	3	122	1	0	0	0	0	1	0	0	0	5626	1493	52	5	131	5	FAM78A	9	134136337	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	3918479	134136337	7077094	87	36681										
GTF3C4	9329	broad.mit.edu	37	chr9	135555086	135555086	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	acatgaagcgagtcttaggaGaagtgtatctgcacacctgg	12	8	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr9:135555086G>A	uc010mzv.2	+	2	2338	c.2080G>A	c.(2080-2082)GAA>AAA	p.E694K	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	694					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		AGTCTTAGGAGAAGTGTATCT	0.478													0	0	0	0.030593	0	30	53										A	135555086	G	A	135555086	3	1	122	1	0	0	0	0	1	0	0	0	6875	943	33	1	2086	1	GTF3C4	9	135555086	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	1418749	135555086	5658345	88	36682										
ITIH2	3698	broad.mit.edu	37	chr10	7774363	7774363	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gacttgcaggattttctatcGaaagacaagcatgcagatcc	9	9	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:7774363G>A	uc001ijs.2	+	14	1872	c.1710G>A	c.(1708-1710)TCG>TCA	p.S570S		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	570					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.S570L(1)		ovary(1)|pancreas(1)|skin(1)	3						ATTTTCTATCGAAAGACAAGC	0.483													0	0	0	0.09319	0	13	43										A	7774363	G	A	7774363	2	1	122	1	0	0	0	0	0	0	0	1	7904	1045	37	1		1	ITIH2	10	7774363	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		7774363	127760384	89	36683										
TAF3	83860	broad.mit.edu	37	chr10	8056618	8056618	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aggccctgtgttggaatcatGactgcacccccagaagagat	11	11	1	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:8056618G>T	uc010qbd.1	+	7	2694	c.2694G>T	c.(2692-2694)ATG>ATT	p.M898I		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	898	PHD-type.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						TTGGAATCATGACTGCACCCC	0.448													1	0	6.4e-05	0.004672	6.46066e-05	3	18										T	8056618	G	T	8056618	3	4	122	1	0	0	0	0	1	0	0	0	15522	1290	45	3	2720	3	TAF3	10	8056618	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	282255	8056618	127478129	90	36684										
PTCHD3	374308	broad.mit.edu	37	chr10	27688159	27688159	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atcatgataaacatgtcatcGaccccaacacctgtaaaaaa	4	11	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:27688159G>A	uc001itu.2	-	4	1486	c.1368C>T	c.(1366-1368)GTC>GTT	p.V456V		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	456	SSD.|Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						ACATGTCATCGACCCCAACAC	0.358													0	0	0	0.055883	0	18	30										A	27688159	G	A	27688159	2	1	122	1	0	0	0	0	0	0	0	1	12734	1045	37	1		1	PTCHD3	10	27688159	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	19631541	27688159	107846588	91	36685										
ADAMTS14	140766	broad.mit.edu	37	chr10	72517796	72517796	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccaacagcctcgggcattgcGagggggataggccagacact	14	12	0	1	rs146237817	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:72517796G>A	uc001jrh.2	+	20	3016	c.3016G>A	c.(3016-3018)GAG>AAG	p.E1006K	ADAMTS14_uc001jrg.2_Missense_Mutation_p.E1009K	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1006	TSP type-1 4.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						CGGGCATTGCGAGGGGGATAG	0.667													0	0	0	0.021553	0	6	79										A	72517796	G	A	72517796	3	1	122	1	0	0	0	0	1	0	0	0	259	1059	37	1	3103	1	ADAMTS14	10	72517796	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	44829637	72517796	63016951	92	36686										
MRPS16	51021	broad.mit.edu	37	chr10	75011600	75011600	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctgtctaggttgagggcaacGagtttttctccatgactgtt	11	8	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:75011600G>A	uc001jts.1	-	2	406	c.195C>T	c.(193-195)CTC>CTT	p.L65L	DNAJC9_uc010qkg.1_5'Flank|MRPS16_uc010qkh.1_RNA|MRPS16_uc001jtt.1_RNA|uc001jtu.1_5'Flank	NM_016065	NP_057149	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16 precursor	65					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0	Prostate(51;0.0119)					TGAGGGCAACGAGTTTTTCTC	0.537													0	0	0	0.048971	0	50	113										A	75011600	G	A	75011600	2	1	122	1	0	0	0	0	0	0	0	1	9826	1045	37	1		1	MRPS16	10	75011600	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	2493804	75011600	60523147	93	36687										
LIPF	8513	broad.mit.edu	37	chr10	90427424	90427424	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aatagaattccttatgggaaGaaaaattcagggaatacagg	10	4	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:90427424G>A	uc001kfg.1	+	3	370	c.204G>A	c.(202-204)AAG>AAA	p.K68K	LIPF_uc009xtk.2_Silent_p.K68K|LIPF_uc001kfh.1_Silent_p.K78K|LIPF_uc010qmt.1_Silent_p.K78K|LIPF_uc010qmu.1_Silent_p.K68K	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	68					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		CTTATGGGAAGAAAAATTCAG	0.214													0	0	0	0.108266	0	25	55										A	90427424	G	A	90427424	2	1	122	1	0	0	0	0	0	0	0	1	8822	933	33	1		1	LIPF	10	90427424	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	15415824	90427424	45107323	94	36688										
DMBT1	1755	broad.mit.edu	37	chr10	124348479	124348479	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggacctgaatccagtttggcCctgaggctggtgaatggagg	16	8	0	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr10:124348479C>T	uc001lgk.1	+	17	1909	c.1803C>T	c.(1801-1803)GCC>GCT	p.A601A	DMBT1_uc001lgl.1_Silent_p.A591A|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Silent_p.A601A|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	601					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCAGTTTGGCCCTGAGGCTGG	0.542													0	0	0	0.047766	0	8	5										T	124348479	C	T	124348479	2	4	122	1	0	0	0	0	0	0	0	1	4577	610	22	2		2	DMBT1	10	124348479	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	33921055	124348479	11186268	95	36689										
MUC5B	727897	broad.mit.edu	37	chr11	1267503	1267503	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccctcctccactccggggacGacctggatcctcacagagct	9	18	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:1267503G>A	uc009ycr.1	+	49	11268	c.11142G>A	c.(11140-11142)ACG>ACA	p.T3714T	MUC5B_uc001ltb.2_Silent_p.T3134T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3131	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCGGGGACGACCTGGATCC	0.657													0	0	0	0.048971	0	58	134										A	1267503	G	A	1267503	2	1	122	1	0	0	0	0	0	0	0	1	9979	1045	37	1		1	MUC5B	11	1267503	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		1267503	133739013	96	36690										
PLEKHA7	144100	broad.mit.edu	37	chr11	16838371	16838390	+	Frame_Shift_Del	DEL	CCTTGGAGAATCCCCCAGCG	CCTTGGAGAATCCCCCAGCG	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	acagcgtggccccgtgccctCcttggagaatcccccagcga					rs142792914		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:16838371_16838390delCCTTGGAGAATCCCCCAGCG	uc001mmo.2	-	11	1838_1857	c.1823_1842delCGCTGGGGGATTCTCCAAGG	c.(1822-1842)TCGCTGGGGGATTCTCCAAGGfs	p.S608fs	PLEKHA7_uc010rcu.1_Frame_Shift_Del_p.S608fs|PLEKHA7_uc010rcv.1_Frame_Shift_Del_p.S182fs|PLEKHA7_uc001mmn.2_Frame_Shift_Del_p.S316fs	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	608_614	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CCCGTGCCCTCCTTGGAGAATCCCCCAGCGAGATGTCCAC	0.641																		9	72	---	---								-	16838390	CCTTGGAGAATCCCCCAGCG	-	16838371	7	5	122	1	0	1	0	1	0	0	0	0	12061	854	30	0	1575	0	PLEKHA7	11	16838371	Frame_Shift_Del	DEL	CCTTGGAGAATCCCCCAGCG	TCGA-GV-A3QK-01B-11D-A23M-08	15570868	16838371	118168145	97	36691										
LGR4	55366	broad.mit.edu	37	chr11	27398722	27398722	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cacatttcttccagagcatgGcaaccattaaaacttggaag	7	10	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:27398722G>T	uc001mrj.3	-	12	1577	c.1092C>A	c.(1090-1092)TGC>TGA	p.C364*	LGR4_uc001mrk.3_Nonsense_Mutation_p.C340*	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	364	Extracellular (Potential).|LRR 12.					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						CCAGAGCATGGCAACCATTAA	0.308													1	0	5.77227e-19	0.037714	6.17836e-19	28	47										T	27398722	G	T	27398722	4	4	122	1	0	0	0	0	0	1	0	0	8756	1195	42	4	1791	4	LGR4	11	27398722	Nonsense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	10560351	27398722	107607794	98	36692										
TMX2	51075	broad.mit.edu	37	chr11	57505121	57505121	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttctcagtgccattgtgatGatgaagaaccgcagatccag	10	9	1	5			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:57505121G>A	uc001nlc.1	+	2	280	c.231G>A	c.(229-231)ATG>ATA	p.M77I	CTNND1_uc001nlf.1_5'UTR|TMX2_uc001nld.1_5'UTR|TMX2_uc001nle.1_Missense_Mutation_p.M77I	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	77	Extracellular (Potential).				cell redox homeostasis	integral to membrane					0						CCATTGTGATGATGAAGAACC	0.433													0	0	0	0.024245	0	13	32										A	57505121	G	A	57505121	3	1	122	1	0	0	0	0	1	0	0	0	16264	1290	45	1	237	1	TMX2	11	57505121	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	30106399	57505121	77501395	99	36693										
CD5	921	broad.mit.edu	37	chr11	60892591	60892591	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggataacgaatacagccaacCtcccaggaactcccacctgt	7	15	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:60892591C>A	uc009ynk.2	+	9	1470	c.1367C>A	c.(1366-1368)CCT>CAT	p.P456H		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	456	Cytoplasmic (Potential).				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		TACAGCCAACCTCCCAGGAAC	0.617													1	0	3.10358e-05	0.069288	3.14792e-05	22	39										A	60892591	C	A	60892591	3	1	122	1	0	0	0	0	1	0	0	0	3021	681	24	4	1401	4	CD5	11	60892591	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	3387470	60892591	74113925	100	36694										
GDPD4	220032	broad.mit.edu	37	chr11	76944073	76944073	+	Silent	SNP	G	G	A													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctggacaaccagctcaccatGaagaagtgagggtgatcaag							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:76944073G>A	uc001oyf.2	-	13	1637	c.1386C>T	c.(1384-1386)TTC>TTT	p.F462F		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	462	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						AGCTCACCATGAAGAAGTGAG	0.557													0	0	0	0.069456	0	13	43										A	76944073	G	A	76944073	2	1	122	1	0	0	0	0	0	0	0	1	6326	1281	45	1		1	GDPD4	11	76944073	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	16051482	76944073	58062443	101	36695	190	2	2	172		3	2	15	N	G	7.959192e-05
GDPD4	220032	broad.mit.edu	37	chr11	76944076	76944076	+	Silent	SNP	G	G	A													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gacaaccagctcaccatgaaGaagtgagggtgatcaagctg							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:76944076G>A	uc001oyf.2	-	13	1634	c.1383C>T	c.(1381-1383)TTC>TTT	p.F461F		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	461	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						TCACCATGAAGAAGTGAGGGT	0.547													0	0	0	0.074837	0	13	43										A	76944076	G	A	76944076	2	1	122	1	0	0	0	0	0	0	0	1	6326	933	33	1		1	GDPD4	11	76944076	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3	76944076	58062440	102	36696	190	2	2	172		3	2	15	N	G	7.959192e-05
GDPD4	220032	broad.mit.edu	37	chr11	76944087	76944087	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	caccatgaagaagtgagggtGatcaagctgactcaggagcc	13	9	2	5			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:76944087G>A	uc001oyf.2	-	13	1623	c.1372C>T	c.(1372-1374)CAC>TAC	p.H458Y		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	458	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						AAGTGAGGGTGATCAAGCTGA	0.537													0	0	0	0.09836	0	18	43										A	76944087	G	A	76944087	3	1	122	1	0	0	0	0	1	0	0	0	6326	1290	45	1	206	1	GDPD4	11	76944087	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	11	76944087	58062429	103	36697			2	172		3	2	15	N	G	7.959192e-05
MMP8	4317	broad.mit.edu	37	chr11	102586120	102586120	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gatggccagaatagagaaatAaaattcatttcgactctttg	8	6	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr11:102586120A>G	uc001phe.2	-	7	1050	c.951T>C	c.(949-951)TTT>TTC	p.F317F	MMP8_uc010rut.1_Silent_p.F252F|MMP8_uc010ruu.1_Silent_p.F294F	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	317	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ATAGAGAAATAAAATTCATTT	0.383													0	0	0	0.0333	0	18	16										G	102586120	A	G	102586120	2	3	122	1	0	0	0	0	0	0	0	1	9668	359	13	5		5	MMP8	11	102586120	Silent	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	25642033	102586120	32420396	104	36698										
MBD6	114785	broad.mit.edu	37	chr12	57920934	57920934	+	Frame_Shift_Del	DEL	C	C	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	acttttccccccactttcagCcccccctaccctcatagctt							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:57920934delC	uc001soj.1	+	7	2230	c.2006delC	c.(2005-2007)GCCfs	p.A669fs	MBD6_uc001sok.1_Frame_Shift_Del_p.A536fs|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	669	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						CCACTTTCAGCCCCCCCTACC	0.642																		28	24	---	---								-	57920934	C	-	57920934	7	5	122	1	0	1	0	1	0	0	0	0	9348	739	26	0	2024	0	MBD6	12	57920934	Frame_Shift_Del	DEL	C	TCGA-GV-A3QK-01B-11D-A23M-08		57920934	75930961	105	36699										
RPH3A	22895	broad.mit.edu	37	chr12	113325677	113325677	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	agattctccctcaagaaactGaagcccaaccagaggaagaa	8	11	2	5			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:113325677G>A	uc010syl.1	+	17	1874	c.1512G>A	c.(1510-1512)CTG>CTA	p.L504L	RPH3A_uc001ttz.2_Silent_p.L504L|RPH3A_uc001tty.2_Silent_p.L500L|RPH3A_uc009zwe.1_Silent_p.L500L|RPH3A_uc010sym.1_Silent_p.L455L|RPH3A_uc001tua.2_Silent_p.L264L	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	504					intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TCAAGAAACTGAAGCCCAACC	0.502													0	0	0	0.048971	0	63	198										A	113325677	G	A	113325677	2	1	122	1	0	0	0	0	0	0	0	1	13551	1277	45	1		1	RPH3A	12	113325677	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	55404743	113325677	20526218	106	36700										
DTX1	1840	broad.mit.edu	37	chr12	113515459	113515459	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cgcagatgaaccgccagacgCgccggcgccgccgcctgcgc	14	19	0	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:113515459C>T	uc001tuk.1	+	2	826	c.490C>T	c.(490-492)CGC>TGC	p.R164C		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	164	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						CCGCCAGAcgcgccggcgccg	0.527													0	0	0	0.038147	0	6	22										T	113515459	C	T	113515459	3	4	122	1	0	0	0	0	1	0	0	0	4793	768	27	2	496	2	DTX1	12	113515459	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	189782	113515459	20336436	107	36701										
SLC24A6	80024	broad.mit.edu	37	chr12	113742153	113742153	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tctgtgtggcttcgggagatCtggagcaggcagcccagccc	15	12	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr12:113742153C>T	uc001tvc.2	-	15	1740	c.1530G>A	c.(1528-1530)CAG>CAA	p.Q510Q	SLC24A6_uc001tuz.2_Silent_p.Q215Q|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Silent_p.Q248Q	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	510	Cytoplasmic (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						TTCGGGAGATCTGGAGCAGGC	0.502													0	0	0	0.048971	0	48	182										T	113742153	C	T	113742153	2	4	122	1	0	0	0	0	0	0	0	1	14470	912	32	1		1	SLC24A6	12	113742153	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	226694	113742153	20109742	108	36702										
FLT3	2322	broad.mit.edu	37	chr13	28609758	28609759	+	Frame_Shift_Ins	INS	-	-	T													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gacacccactgtccaaacacINSttttctgttagcctttctat							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:28609758_28609759insT	uc001urw.2	-	12	1552_1553	c.1470_1471insA	c.(1468-1473)AAAGTGfs	p.K490fs	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Frame_Shift_Ins_p.K490fs	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	490_491	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TGTCCAAACACTTTTCTGTTAG	0.426			Mis|O		AML|ALL													60	126	---	---								T	28609759	-	T	28609758	7	5	122	1	0	1	1	0	0	0	0	0	5942	565	20	0	1562	0	FLT3	13	28609758	Frame_Shift_Ins	INS	-	TCGA-GV-A3QK-01B-11D-A23M-08		28609758	86560120	109	36703										
NBEA	26960	broad.mit.edu	37	chr13	35731303	35731303	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctgaggaacagaagattaccGaaatggtctacaatatcttc	8	8	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:35731303G>T	uc001uvb.2	+	22	2946	c.2740G>T	c.(2740-2742)GAA>TAA	p.E914*		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	914						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GAAGATTACCGAAATGGTCTA	0.408													1	0	1.84765e-07	0.064281	1.89206e-07	37	76										T	35731303	G	T	35731303	4	4	122	1	0	0	0	0	0	1	0	0	10187	1059	37	3	2822	3	NBEA	13	35731303	Nonsense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	7121545	35731303	79438575	110	36704										
PCDH8	5100	broad.mit.edu	37	chr13	53421499	53421499	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcgcgcctggggcggccagcGgggtgatggcgatgtcgggt	22	10	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:53421499G>A	uc001vhi.2	-	1	1276	c.1073C>T	c.(1072-1074)CCG>CTG	p.P358L	PCDH8_uc001vhj.2_Missense_Mutation_p.P358L	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	358	Extracellular (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		GGCGGCCAGCGGGGTGATGGC	0.761													0	0	0	0.047766	0	8	14										A	53421499	G	A	53421499	3	1	122	1	0	0	0	0	1	0	0	0	11517	1116	39	2	2151	2	PCDH8	13	53421499	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	17690196	53421499	61748379	111	36705										
KLF5	688	broad.mit.edu	37	chr13	73649881	73649881	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	agtgtacctgggaaggctgcGactggaggttcgcgcgatcg	17	9	0	0	rs144543104		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:73649881G>T	uc001vje.2	+	4	1555	c.1231G>T	c.(1231-1233)GAC>TAC	p.D411Y	KLF5_uc001vjd.2_Missense_Mutation_p.D320Y	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	411	C2H2-type 2.				transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GGAAGGCTGCGACTGGAGGTT	0.577													1	0	9.90819e-18	0.048971	1.04997e-17	54	137										T	73649881	G	T	73649881	3	4	122	1	0	0	0	0	1	0	0	0	8349	1058	37	3	1245	3	KLF5	13	73649881	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	20228382	73649881	41519997	112	36706			3	173		2	2	12	N	G_C	6.253704e-05
KLF5	688	broad.mit.edu	37	chr13	73649892	73649892	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gaaggctgcgactggaggttCgcgcgatcggatgagctgac	17	9	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:73649892C>T	uc001vje.2	+	4	1566	c.1242C>T	c.(1240-1242)TTC>TTT	p.F414F	KLF5_uc001vjd.2_Silent_p.F323F	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	414	C2H2-type 2.				transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		ACTGGAGGTTCGCGCGATCGG	0.582													0	0	0	0.11126	0	43	108										T	73649892	C	T	73649892	2	4	122	1	0	0	0	0	0	0	0	1	8349	883	31	1		1	KLF5	13	73649892	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	11	73649892	41519986	113	36707			3	173		2	2	12	N	G_C	6.253704e-05
ABCC4	10257	broad.mit.edu	37	chr13	95813572	95813572	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tcttgctatgccaaaaagaaCggtagctacagttaaacctg	8	9	1	1	rs146708960		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:95813572C>T	uc001vmd.3	-	19	2445	c.2326G>A	c.(2326-2328)GTT>ATT	p.V776I	ABCC4_uc010afk.2_Missense_Mutation_p.V729I|ABCC4_uc001vme.2_Missense_Mutation_p.V776I|ABCC4_uc010tih.1_Missense_Mutation_p.V701I	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	776	ABC transmembrane type-1 2.|Helical; (Potential).		V -> I (20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type).		platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CCAAAAAGAACGGTAGCTACA	0.358													0	0	0	0.058154	0	10	39										T	95813572	C	T	95813572	3	4	122	1	0	0	0	0	1	0	0	0	55	536	19	2	1752	2	ABCC4	13	95813572	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	22163680	95813572	19356306	114	36708										
COL4A1	1282	broad.mit.edu	37	chr13	110830437	110830437	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	acccaggaatcccaggagccCcctgctgtccaggaaggcca	11	16	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr13:110830437C>T	uc001vqw.3	-	32	2722	c.2600G>A	c.(2599-2601)GGG>GAG	p.G867E	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	867	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCCAGGAGCCCCCTGCTGTCC	0.547													0	0	0	0.048971	0	50	109										T	110830437	C	T	110830437	3	4	122	1	0	0	0	0	1	0	0	0	3689	623	22	2	2493	2	COL4A1	13	110830437	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	15016865	110830437	4339441	115	36709										
RNASE3	6037	broad.mit.edu	37	chr14	21359944	21359944	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gccagacccccacagtttacGagggctcagtggtttgccat	11	13	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:21359944G>T	uc001vyj.2	+	2	153	c.99G>T	c.(97-99)ACG>ACT	p.T33T		NM_002935	NP_002926	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3 (eosinophil	33					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	CACAGTTTACGAGGGCTCAGT	0.507													1	0	3.70713e-34	0.048971	4.0702e-34	47	109										T	21359944	G	T	21359944	2	4	122	1	0	0	0	0	0	0	0	1	13405	1045	37	3		3	RNASE3	14	21359944	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		21359944	85989596	116	36710										
C14orf21	161424	broad.mit.edu	37	chr14	24769970	24769970	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttgtctactgtggagacacaCatggcagcttcgtggtcaga	12	9	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:24769970C>T	uc001wol.1	+	2	667	c.604C>T	c.(604-606)CAT>TAT	p.H202Y	C14orf21_uc001wom.1_5'Flank|DHRS1_uc001woj.1_5'Flank|DHRS1_uc001wok.2_5'Flank	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	202	Pumilio 2.						RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		TGGAGACACACATGGCAGCTT	0.527													0	0	0	0.048971	0	54	107										T	24769970	C	T	24769970	3	4	122	1	0	0	0	0	1	0	0	0	1769	478	17	2	610	2	C14orf21	14	24769970	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	3410026	24769970	82579570	117	36711										
ARHGAP5	394	broad.mit.edu	37	chr14	32561150	32561150	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cagcatctgatatccgagaaGaggagggtggaaatgaagga	15	5	1	4			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:32561150G>C	uc001wrl.2	+	2	1514	c.1275G>C	c.(1273-1275)AAG>AAC	p.K425N	ARHGAP5_uc001wrm.2_Missense_Mutation_p.K425N|ARHGAP5_uc001wrn.2_Missense_Mutation_p.K425N|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	425					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TATCCGAGAAGAGGAGGGTGG	0.393													0	0	0	0.069456	0	38	58										C	32561150	G	C	32561150	3	2	122	1	0	0	0	0	1	0	0	0	886	933	33	1	1277	1	ARHGAP5	14	32561150	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	7791180	32561150	74788390	118	36712										
FOXA1	3169	broad.mit.edu	37	chr14	38060758	38060762	+	Frame_Shift_Del	DEL	GCTCC	GCTCC	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gaagtccagcttatgctgctGctccgaggaggacatgaggt							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08			GCTCC	-	GCTCC	GCTCC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:38060758_38060762delGCTCC	uc001wuf.2	-	2	1539_1543	c.1227_1231delGGAGC	c.(1225-1233)TCGGAGCAGfs	p.S409fs	FOXA1_uc010tpz.1_Frame_Shift_Del_p.S376fs	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	409_411					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TTATGCTGCTGCTCCGAGGAGGACA	0.6																		11	49	---	---								-	38060762	GCTCC	-	38060758	7	5	122	1	0	1	0	1	0	0	0	0	5989	1328	46	0	191	0	FOXA1	14	38060758	Frame_Shift_Del	DEL	GCTCC	TCGA-GV-A3QK-01B-11D-A23M-08	5499608	38060758	69288782	119	36713										
PPM1A	5494	broad.mit.edu	37	chr14	60750068	60750068	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tcctactgagcagcttgtctCaccagagcctgaagtccatg	9	13	1	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:60750068C>T	uc010apn.2	+	3	1049	c.647C>T	c.(646-648)TCA>TTA	p.S216L	PPM1A_uc001xew.3_Missense_Mutation_p.S289L|PPM1A_uc001xex.3_Missense_Mutation_p.S216L|PPM1A_uc001xey.3_Missense_Mutation_p.S216L	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	216					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		CAGCTTGTCTCACCAGAGCCT	0.443													0	0	0	0.048971	0	55	112										T	60750068	C	T	60750068	3	4	122	1	0	0	0	0	1	0	0	0	12335	838	29	1	872	1	PPM1A	14	60750068	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	22689310	60750068	46599472	120	36714										
ZFP36L1	677	broad.mit.edu	37	chr14	69256761	69256761	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgaagtggcagcggggcccgTaggggcaaaagccgatggtg	19	8	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:69256761T>C	uc001xkh.1	-	2	636	c.506A>G	c.(505-507)TAC>TGC	p.Y169C	ZFP36L1_uc001xki.1_Missense_Mutation_p.Y169C	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	169	C3H1-type 2.				regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCGGGGCCCGTAGGGGCAAAA	0.672											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.042209	0	38	83										C	69256761	T	C	69256761	3	2	122	1	0	0	0	0	1	0	0	0	17643	1638	57	5	514	5	ZFP36L1	14	69256761	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	8506693	69256761	38092779	121	36715										
C14orf49	161176	broad.mit.edu	37	chr14	95884264	95884264	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctcttccctgattgggagcaGgaacagcaggaggaggaaca	14	9	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:95884264G>A	uc001yei.3	-	17	2842	c.2827C>T	c.(2827-2829)CTG>TTG	p.L943L	C14orf49_uc010avi.2_Silent_p.L938L	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	943	Helical; Anchor for type IV membrane protein; (Potential).|KASH.				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		ATTGGGagcaggaacagcagg	0.493													0	0	0	0.048971	0	47	74										A	95884264	G	A	95884264	2	1	122	1	0	0	0	0	0	0	0	1	1776	991	35	2		2	C14orf49	14	95884264	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	26627503	95884264	11465276	122	36716										
HHIPL1	84439	broad.mit.edu	37	chr14	100118593	100118593	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tatgcagcccacctctatgaCgccgaggacccattcacgcc	8	17	2	1	rs142575301		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr14:100118593C>T	uc010avs.2	+	2	353	c.288C>T	c.(286-288)GAC>GAT	p.D96D	HHIPL1_uc001ygl.1_Silent_p.D96D	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	96					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				ACCTCTATGACGCCGAGGACC	0.522													0	0	0	0.099896	0	27	68										T	100118593	C	T	100118593	2	4	122	1	0	0	0	0	0	0	0	1	7093	535	19	2		2	HHIPL1	14	100118593	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	4234329	100118593	7230947	123	36717										
UNC13C	440279	broad.mit.edu	37	chr15	54793159	54793159	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctgaagcattatctcacttaAtgagaagatttgcaaaggta	8	6	1	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:54793159A>C	uc002ack.2	+	20	5284	c.5284A>C	c.(5284-5286)ATG>CTG	p.M1762L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1762	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCTCACTTAATGAGAAGATT	0.368													0	0	0	0.045515	0	44	75										C	54793159	A	C	54793159	3	2	122	1	0	0	0	0	1	0	0	0	16983	101	4	5	5362	5	UNC13C	15	54793159	Missense_Mutation	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08		54793159	47738233	124	36718										
TLN2	83660	broad.mit.edu	37	chr15	63128203	63128203	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gccaagcaggtcgccgcttcCacggctcagctgctggtggc	14	15	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:63128203C>G	uc002alb.3	+	54	7305	c.7305C>G	c.(7303-7305)TCC>TCG	p.S2435S	TLN2_uc002alc.3_Silent_p.S828S|TLN2_uc010uic.1_Silent_p.S36S|uc002ale.1_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2435	I/LWEQ.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TCGCCGCTTCCACGGCTCAGC	0.612													0	0	0	0.105934	0	14	25										G	63128203	C	G	63128203	2	3	122	1	0	0	0	0	0	0	0	1	15945	581	21	4		4	TLN2	15	63128203	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	8335044	63128203	39403189	125	36719										
HERC1	8925	broad.mit.edu	37	chr15	63927026	63927026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gacgaccatagtcaccattcCcaaaggtgaacagtttgcca	8	12	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:63927026C>T	uc002amp.2	-	66	12624	c.12476G>A	c.(12475-12477)GGG>GAG	p.G4159E		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4159	RCC1 11.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GTCACCATTCCCAAAGGTGAA	0.448													0	0	0	0.105934	0	14	18										T	63927026	C	T	63927026	3	4	122	1	0	0	0	0	1	0	0	0	7057	623	22	2	2161	2	HERC1	15	63927026	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	798823	63927026	38604366	126	36720										
THSD4	79875	broad.mit.edu	37	chr15	72030322	72030322	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggaagcagcttgggacaacaGaatgttccacgacctgtggg	14	9	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:72030322G>C	uc002atb.1	+	10	1961	c.1882G>C	c.(1882-1884)GAA>CAA	p.E628Q	THSD4_uc010ukg.1_Missense_Mutation_p.E268Q|THSD4_uc002ate.2_Missense_Mutation_p.E268Q	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	628						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TGGGACAACAGAATGTTCCAC	0.587													0	0	0	0.055883	0	20	43										C	72030322	G	C	72030322	3	2	122	1	0	0	0	0	1	0	0	0	15875	943	33	1	1920	1	THSD4	15	72030322	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	8103296	72030322	30501070	127	36721										
NEO1	4756	broad.mit.edu	37	chr15	73428236	73428236	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttttttttaacacagctctGaaagattggtattgctggca	8	6	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr15:73428236G>A	uc002avm.3	+	5	1025	c.883G>A	c.(883-885)GAA>AAA	p.E295K	NEO1_uc010ukx.1_Missense_Mutation_p.E295K|NEO1_uc010uky.1_Missense_Mutation_p.E295K|NEO1_uc010ukz.1_5'UTR|NEO1_uc002avn.3_5'UTR	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	295	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						ACACAGCTCTGAAAGATTGGT	0.338													0	0	0	0.02938	0	5	8										A	73428236	G	A	73428236	3	1	122	1	0	0	0	0	1	0	0	0	10336	1291	45	1	901	1	NEO1	15	73428236	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	1397914	73428236	29103156	128	36722										
SRRM2	23524	broad.mit.edu	37	chr16	2820448	2820448	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccgtccctcgccccagccctCaccacgggaccagcagaggt	10	20	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:2820448C>T	uc002crk.2	+	13	8666	c.8117C>T	c.(8116-8118)TCA>TTA	p.S2706L		NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2706	Ser-rich.|Arg-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCCCAGCCCTCACCACGGGAC	0.642													0	0	0	0.02938	0	7	12										T	2820448	C	T	2820448	3	4	122	1	0	0	0	0	1	0	0	0	15168	838	29	1	8163	1	SRRM2	16	2820448	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		2820448	87534305	129	36723										
MEFV	4210	broad.mit.edu	37	chr16	3297033	3297033	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cacctgcagaagttcccattCtgactggcactccttggcct	8	15	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:3297033C>T	uc002cun.1	-	5	1610	c.1570G>A	c.(1570-1572)GAA>AAA	p.E524K		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	524					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	AGTTCCCATTCTGACTGGCAC	0.617													0	0	0	0.048971	0	51	74										T	3297033	C	T	3297033	3	4	122	1	0	0	0	0	1	0	0	0	9459	922	32	1	799	1	MEFV	16	3297033	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	476585	3297033	87057720	130	36724										
TNRC6A	27327	broad.mit.edu	37	chr16	24826603	24826603	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgccaaatcgcctaacggctCtagcagtgttaattggccac	9	12	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:24826603C>G	uc002dmm.2	+	19	4922	c.4808C>G	c.(4807-4809)TCT>TGT	p.S1603C	TNRC6A_uc010bxs.2_Missense_Mutation_p.S1350C|TNRC6A_uc002dmn.2_Missense_Mutation_p.S1301C|TNRC6A_uc002dmo.2_Missense_Mutation_p.S1242C|TNRC6A_uc002dmp.2_Missense_Mutation_p.S204C|TNRC6A_uc002dmq.2_Missense_Mutation_p.S270C	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1603					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CCTAACGGCTCTAGCAGTGTT	0.433													0	0	0	0.0918	0	26	34										G	24826603	C	G	24826603	3	3	122	1	0	0	0	0	1	0	0	0	16337	913	32	1	4882	1	TNRC6A	16	24826603	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	21529570	24826603	65528150	131	36725										
MYLK3	91807	broad.mit.edu	37	chr16	46744549	46744549	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgacaagcaatgaaaggtacCtcttctctttgaccagcaac	7	11	2	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:46744549C>T	uc002eei.3	-	11	2383	c.2267G>A	c.(2266-2268)AGC>AAC	p.S756N	MYLK3_uc010vge.1_Missense_Mutation_p.S415N	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	756	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGAAAGGTACCTCTTCTCTTT	0.532													0	0	0	0.045515	0	43	101										T	46744549	C	T	46744549	3	4	122	1	0	0	0	0	1	0	0	0	10058	695	24	2	204	2	MYLK3	16	46744549	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	21917946	46744549	43610204	132	36726										
MYLK3	91807	broad.mit.edu	37	chr16	46766181	46766181	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cttactgcttcagctctcacCggagccctggctgcacagtc	9	16	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:46766181C>A	uc002eei.3	-	4	1517	c.1401G>T	c.(1399-1401)CCG>CCT	p.P467P	MYLK3_uc010vge.1_Silent_p.P126P|MYLK3_uc002eej.1_Silent_p.P126P	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	467					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CAGCTCTCACCGGAGCCCTGG	0.657													1	0	5.60225e-13	0.041601	5.84941e-13	32	61										A	46766181	C	A	46766181	2	1	122	1	0	0	0	0	0	0	0	1	10058	639	23	4		4	MYLK3	16	46766181	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	21632	46766181	43588572	133	36727										
ZNF423	23090	broad.mit.edu	37	chr16	49671231	49671231	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gccgcttcggggaagacaccTccacatcggacgagactggg	14	13	0	2	rs114911915	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:49671231T>A	uc002efs.2	-	5	2130	c.1832A>T	c.(1831-1833)GAG>GTG	p.E611V	ZNF423_uc010vgn.1_Missense_Mutation_p.E494V	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	611					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGAAGACACCTCCACATCGGA	0.547													0	0	0	0.048971	0	46	60										A	49671231	T	A	49671231	3	1	122	1	0	0	0	0	1	0	0	0	17895	1551	54	5	2042	5	ZNF423	16	49671231	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	2905050	49671231	40683522	134	36728										
PARD6A	50855	broad.mit.edu	37	chr16	67695399	67695399	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttcgcgctgcctcgcgcttcGgtgagcggcttccaggagtt	14	13	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:67695399G>A	uc002ett.2	+	2	196	c.105G>A	c.(103-105)TCG>TCA	p.S35S	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Silent_p.S35S|PARD6A_uc002etu.2_5'UTR	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	35	Interaction with PRKCI and PRKCZ.|OPR.				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCGCGCTTCGGTGAGCGGCT	0.657													0	0	0	0.039052	0	38	87										A	67695399	G	A	67695399	2	1	122	1	0	0	0	0	0	0	0	1	11445	1103	39	2		2	PARD6A	16	67695399	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	18024168	67695399	22659354	135	36729										
LDHD	197257	broad.mit.edu	37	chr16	75149486	75149487	+	Missense_Mutation	DNP	CC	CC	TT													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cccgtgctgctctcggaccaCcgcggcagtggacacgtggg							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:75149486_75149487CC>TT	uc002fdm.2	-	2	191_192	c.144_145GG>AA	c.(142-147)GCGGTG>GCAATG	p.V49M	LDHD_uc002fdn.2_Missense_Mutation_p.V49M	NM_153486	NP_705690	Q86WU2	LDHD_HUMAN	D-lactate dehydrogenase isoform 1 precursor	49							D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding				0						TCTCGGACCACCGCGGCAGTGG	0.649													0	0	0	0.004672	0	7	38										TT	75149487	CC	TT	75149486	3	4	122	1	0	0	0	0	1	0	0	0	8703	507	18	2	1418	2	LDHD	16	75149486	Missense_Mutation	DNP	CC	TCGA-GV-A3QK-01B-11D-A23M-08	7454087	75149486	15205267	136	36730										
RPL13	6137	broad.mit.edu	37	chr16	89629441	89629441	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcagaacaggatgttgaaaaGaaaaaataaagccctcctgg	10	7	0	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr16:89629441G>T	uc002fnm.1	+	6	678	c.627G>T	c.(625-627)AAG>AAT	p.K209N	RPL13_uc010vpj.1_Missense_Mutation_p.K162N|RPL13_uc002fnn.1_Missense_Mutation_p.K209N|RPL13_uc002fno.1_3'UTR	NM_000977	NP_000968	P26373	RL13_HUMAN	ribosomal protein L13	209					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic ribosome	protein binding|RNA binding|structural constituent of ribosome				0		all_hematologic(23;0.0748)		all cancers(4;1.15e-07)|OV - Ovarian serous cystadenocarcinoma(4;7.8e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0139)		ATGTTGAAAAGAAAAAATAAA	0.557													1	0	2.10051e-16	0.09319	2.21489e-16	12	21										T	89629441	G	T	89629441	3	4	122	1	0	0	0	0	1	0	0	0	13559	933	33	3	645	3	RPL13	16	89629441	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	14479955	89629441	725312	137	36731										
RILP	83547	broad.mit.edu	37	chr17	1551226	1551226	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggcctcgagcagaaggccggGgacccggtggtctgtgagca	18	11	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:1551226G>A	uc002ftd.2	-	6	1141	c.847C>T	c.(847-849)CCC>TCC	p.P283S	SCARF1_uc002fsy.1_5'Flank|SCARF1_uc002fsz.1_5'Flank|SCARF1_uc002fta.1_5'Flank|SCARF1_uc010cjv.1_5'Flank	NM_031430	NP_113618	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	283	Necessary for the interaction with RAB7 and RAB34, lysosomal distribution and morphology.				endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AGAAGGCCGGGGACCCGGTGG	0.602													0	0	0	0.0918	0	25	36										A	1551226	G	A	1551226	3	1	122	1	0	0	0	0	1	0	0	0	13360	1232	43	2	370	2	RILP	17	1551226	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		1551226	79643984	138	36732										
ITGAE	3682	broad.mit.edu	37	chr17	3661102	3661104	+	In_Frame_Del	DEL	GAC	GAC	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccatcggtgagcaccaccatGaccttggatgcctttctcct							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:3661102_3661104delGAC	uc002fwo.3	-	9	1015_1017	c.916_918delGTC	c.(916-918)GTCdel	p.V306del		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	306	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GCACCACCATGACCTTGGATGCC	0.532																		13	300	---	---								-	3661104	GAC	-	3661102	7	5	122	1	0	1	0	1	0	0	0	0	7885	1277	45	0	2713	0	ITGAE	17	3661102	In_Frame_Del	DEL	GAC	TCGA-GV-A3QK-01B-11D-A23M-08	2109876	3661102	77534108	139	36733										
TP53	7157	broad.mit.edu	37	chr17	7579472	7579472	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctgctggtgcaggggccacgGggggagcagcctctggcatt	18	11	1	0	rs1042522	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:7579472G>C	uc002gim.2	-	4	409	c.215C>G	c.(214-216)CCC>CGC	p.P72R	TP53_uc002gig.1_Missense_Mutation_p.P72R|TP53_uc002gih.2_Missense_Mutation_p.P72R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.P72R|TP53_uc010cni.1_Missense_Mutation_p.P72R|TP53_uc002gij.2_Missense_Mutation_p.P72R|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.P33R|TP53_uc010cnk.1_Missense_Mutation_p.P87R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	72	Interaction with WWOX.|Interaction with HRMT1L2.		P -> C (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> L (in a sporadic cancer; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> G (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.R72fs*51(6)|p.G59fs*23(3)|p.R72C(2)|p.R72H(2)|p.E68fs*76(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.R65fs*38(1)|p.D57_A76del20(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGCCACGGGGGGAGCAGC	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.09319	0	12	141										C	7579472	G	C	7579472	3	2	122	1	0	0	0	0	1	0	0	0	16378	1232	43	4	1087	4	TP53	17	7579472	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3918370	7579472	73615738	140	36734										
GAS2L2	246176	broad.mit.edu	37	chr17	34073278	34073278	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aagatgtgggaatccttcccCtggggagttcaggggggtat	16	7	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:34073278C>T	uc002hjv.1	-	6	1266	c.1238G>A	c.(1237-1239)AGG>AAG	p.R413K		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	413					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AATCCTTCCCCTGGGGAGTTC	0.597													0	0	0	0.048971	0	154	150										T	34073278	C	T	34073278	3	4	122	1	0	0	0	0	1	0	0	0	6247	681	24	2	1408	2	GAS2L2	17	34073278	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	26493806	34073278	47121932	141	36735										
STARD3	10948	broad.mit.edu	37	chr17	37809815	37809815	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgcccagggagctgacccgaGacttggagcgcagcctgcct	14	14	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:37809815G>A	uc002hsd.2	+	2	155	c.31G>A	c.(31-33)GAC>AAC	p.D11N	STARD3_uc010weg.1_Missense_Mutation_p.D11N|STARD3_uc010weh.1_RNA|STARD3_uc002hse.2_Missense_Mutation_p.D11N|STARD3_uc010wei.1_Missense_Mutation_p.D11N|STARD3_uc002hsf.2_5'UTR	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	11	Cytoplasmic (Potential).				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GCTGACCCGAGACTTGGAGCG	0.716											OREG0024381	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.043863	0	16	74										A	37809815	G	A	37809815	3	1	122	1	0	0	0	0	1	0	0	0	15256	942	33	1	33	1	STARD3	17	37809815	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3736537	37809815	43385395	142	36736										
NSF	4905	broad.mit.edu	37	chr17	44827187	44827187	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctagccgcaaagatgtccttCaggagatggaaatgcttaac	10	9	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:44827187C>A	uc002iku.2	+	18	2061	c.1957C>A	c.(1957-1959)CAG>AAG	p.Q653K	NSF_uc010wke.1_Missense_Mutation_p.Q559K|NSF_uc010wkf.1_Missense_Mutation_p.Q559K|NSF_uc010wkg.1_Missense_Mutation_p.Q648K	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	653					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		AGATGTCCTTCAGGAGATGGA	0.448													1	0	6.00712e-18	0.050027	6.39759e-18	29	109										A	44827187	C	A	44827187	3	1	122	1	0	0	0	0	1	0	0	0	10671	827	29	3	2027	3	NSF	17	44827187	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	7017372	44827187	36368023	143	36737										
COIL	8161	broad.mit.edu	37	chr17	55023818	55023818	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctcaccaggtaaggatgaaaGaatttctatatctacttgct	7	8	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:55023818G>A	uc002iuu.2	-	5	1574	c.1543C>T	c.(1543-1545)CTT>TTT	p.L515F		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	515	2 X 4 AA repeats of S-L-P-A.					Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					AAGGATGAAAGAATTTCTATA	0.308													0	0	0	0.048971	0	47	161										A	55023818	G	A	55023818	3	1	122	1	0	0	0	0	1	0	0	0	3665	942	33	1	199	1	COIL	17	55023818	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	10196631	55023818	26171392	144	36738										
SMARCD2	6603	broad.mit.edu	37	chr17	61910950	61910950	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggagccagagggcccaccttGacatcaagggaggcgatctc	14	12	2	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:61910950G>A	uc010deb.1	-	10	1631	c.1314C>T	c.(1312-1314)GTC>GTT	p.V438V	SMARCD2_uc010wpt.1_Silent_p.V390V|SMARCD2_uc010dea.1_Silent_p.V363V|SMARCD2_uc010dec.1_Silent_p.V417V	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	438					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						GGCCCACCTTGACATCAAGGG	0.577													0	0	0	0.045515	0	40	121										A	61910950	G	A	61910950	2	1	122	1	0	0	0	0	0	0	0	1	14778	1277	45	1		1	SMARCD2	17	61910950	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	6887132	61910950	19284260	145	36739										
ABCA8	10351	broad.mit.edu	37	chr17	66915581	66915581	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgagattttctaggtcagccAtttctgaaagcttattgtta	8	6	3	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr17:66915581A>G	uc002jhp.2	-	13	1828	c.1649T>C	c.(1648-1650)ATG>ACG	p.M550T	ABCA8_uc002jhq.2_Missense_Mutation_p.M550T|ABCA8_uc010wqq.1_Missense_Mutation_p.M550T|ABCA8_uc010wqr.1_Missense_Mutation_p.M489T|ABCA8_uc002jhr.2_Missense_Mutation_p.M550T	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	550	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					TAGGTCAGCCATTTCTGAAAG	0.368													0	0	0	0.062417	0	19	82										G	66915581	A	G	66915581	3	3	122	1	0	0	0	0	1	0	0	0	38	217	8	5	3200	5	ABCA8	17	66915581	Missense_Mutation	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	5004631	66915581	14279629	146	36740										
DCC	1630	broad.mit.edu	37	chr18	50985651	50985651	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggaagggcagccagaaggacCtccgaccccctgatctttgg	13	13	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr18:50985651C>A	uc002lfe.1	+	24	4029	c.3442C>A	c.(3442-3444)CTC>ATC	p.L1148I	DCC_uc010dpf.1_Missense_Mutation_p.L783I	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1148	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CCAGAAGGACCTCCGACCCCC	0.493													1	0	1.49552e-23	0.048971	1.63357e-23	70	27										A	50985651	C	A	50985651	3	1	122	1	0	0	0	0	1	0	0	0	4282	681	24	4	3536	4	DCC	18	50985651	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		50985651	27091597	147	36741										
SERPINB11	89778	broad.mit.edu	37	chr18	61383320	61383320	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	aagccaggttgcaaactgtgGattttgaacagtctacagaa	10	7	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr18:61383320G>A	uc002ljk.3	+	6	471	c.409G>A	c.(409-411)GAT>AAT	p.D137N	SERPINB11_uc010xes.1_Intron|SERPINB11_uc010dqd.2_Missense_Mutation_p.D23N|SERPINB11_uc002ljj.3_Missense_Mutation_p.D23N|SERPINB11_uc010dqe.2_Intron|SERPINB11_uc010dqf.2_Intron	NM_080475	NP_536723	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B, member 11	137					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)	1		Esophageal squamous(42;0.129)				GCAAACTGTGGATTTTGAACA	0.343													0	0	0	0.049695	0	18	10										A	61383320	G	A	61383320	3	1	122	1	0	0	0	0	1	0	0	0	14098	1174	41	1	423	1	SERPINB11	18	61383320	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	10397669	61383320	16693928	148	36742										
POLRMT	5442	broad.mit.edu	37	chr19	619039	619039	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tagggctggatgacggggacGcccaggggtgtgacccactc	17	11	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:619039G>A	uc002lpf.1	-	15	3281	c.3225C>T	c.(3223-3225)GGC>GGT	p.G1075G		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1075	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGACGGGGACGCCCAGGGGTG	0.647													0	0	0	0.049695	0	20	21										A	619039	G	A	619039	2	1	122	1	0	0	0	0	0	0	0	1	12238	1074	38	2		2	POLRMT	19	619039	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		619039	58509944	149	36743										
AP3D1	8943	broad.mit.edu	37	chr19	2110148	2110148	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgcataccttggcaatgaagGacagggtccccttgagcttc	11	11	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:2110148G>A	uc002luz.2	-	26	3288	c.3065C>T	c.(3064-3066)TCC>TTC	p.S1022F	AP3D1_uc010dsv.2_Missense_Mutation_p.S112F|AP3D1_uc002luy.2_Missense_Mutation_p.S981F|AP3D1_uc002lva.2_Missense_Mutation_p.S1084F	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	1022					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCAATGAAGGACAGGGTCCC	0.632													0	0	0	0.069288	0	21	42										A	2110148	G	A	2110148	3	1	122	1	0	0	0	0	1	0	0	0	746	1174	41	1	416	1	AP3D1	19	2110148	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	1491109	2110148	57018835	150	36744										
SAFB	6294	broad.mit.edu	37	chr19	5668195	5668195	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcggcagctttgccccaggcGgggcctcccggggccacccc	15	19	0	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:5668195G>A	uc002mcf.2	+	21	2694	c.2641G>A	c.(2641-2643)GGG>AGG	p.G881R	SAFB_uc002mcg.2_Missense_Mutation_p.G883R|SAFB_uc002mce.3_Missense_Mutation_p.G882R|SAFB_uc010xir.1_Missense_Mutation_p.G880R|SAFB_uc010xis.1_Missense_Mutation_p.G814R|SAFB_uc010xit.1_Missense_Mutation_p.G725R|SAFB_uc010xiu.1_Missense_Mutation_p.G682R	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	881	Interaction with SAFB2.|Gly-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		TGCCCCAGGCGGGGCCTCCCG	0.682													0	0	0	0.048971	0	46	78										A	5668195	G	A	5668195	3	1	122	1	0	0	0	0	1	0	0	0	13806	1116	39	2	2723	2	SAFB	19	5668195	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3558047	5668195	53460788	151	36745										
ICAM3	3385	broad.mit.edu	37	chr19	10445321	10445321	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggtagcatttagctgaagttGagctggctgccccggggccg	16	10	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:10445321G>C	uc002mob.2	-	5	1130	c.1075C>G	c.(1075-1077)CAA>GAA	p.Q359E	RAVER1_uc002moa.2_5'Flank|ICAM3_uc010dxd.1_Missense_Mutation_p.Q282E	NM_002162	NP_002153	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3 precursor	359	Extracellular (Potential).|Ig-like C2-type 4.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			AGCTGAAGTTGAGCTGGCTGC	0.632													0	0	0	0.074837	0	32	67										C	10445321	G	C	10445321	3	2	122	1	0	0	0	0	1	0	0	0	7481	1299	45	1	580	1	ICAM3	19	10445321	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	4777126	10445321	48683662	152	36746										
ZNF799	90576	broad.mit.edu	37	chr19	12491949	12491949	+	Missense_Mutation	SNP	T	T	C													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cgagtggcaataactgaaggTtttccaaaattgtttacgtg					rs11668955	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:12491949T>C	uc002mts.3	-	4	593	c.127A>G	c.(127-129)ACC>GCC	p.T43A				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TAACTGAAGGTTTTCCAAAAT	0.403													0	0	0	0.004672	0	3	24										C	12491949	T	C	12491949	3	2	122	1	0	0	0	0	1	0	0	0	18163	1740	60	5		5	ZNF799	19	12491949	Missense_Mutation	SNP	T	TCGA-GV-A3QK-01B-11D-A23M-08	2046628	12491949	46637034	153	36747	191	2								
ZNF799	90576	broad.mit.edu	37	chr19	12491955	12491955	+	Missense_Mutation	SNP	A	A	C													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcaataactgaaggttttccAaaattgtttacgtgtattac					rs11668074	by1000genomes	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:12491955A>C	uc002mts.3	-	4	587	c.121T>G	c.(121-123)TGG>GGG	p.W41G				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						AAGGTTTTCCAAAATTGTTTA	0.408													0	0	0	0.004672	0	3	20										C	12491955	A	C	12491955	3	2	122	1	0	0	0	0	1	0	0	0	18163	145	5	5		5	ZNF799	19	12491955	Missense_Mutation	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	6	12491955	46637028	154	36748	191	2								
SLC5A5	6528	broad.mit.edu	37	chr19	17992856	17992856	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	cggagcctggcacccaggaaActcgtgattatctccaaggg	12	12	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:17992856A>T	uc002nhr.3	+	9	1493	c.1146A>T	c.(1144-1146)AAA>AAT	p.K382N		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	382	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CACCCAGGAAACTCGTGATTA	0.577													0	0	0	0.108266	0	28	52										T	17992856	A	T	17992856	3	4	122	1	0	0	0	0	1	0	0	0	14668	40	2	5	1180	5	SLC5A5	19	17992856	Missense_Mutation	SNP	A	TCGA-GV-A3QK-01B-11D-A23M-08	5500901	17992856	41136127	155	36749										
MAST3	23031	broad.mit.edu	37	chr19	18234408	18234408	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	agcccgggccgtgcaacgggGaccttcgacaatgagattgt	14	11	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:18234408G>A	uc002nhz.3	+	7	489	c.489G>A	c.(487-489)GGG>GGA	p.G163G		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	163							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GTGCAACGGGGACCTTCGACA	0.602													0	0	0	0.014758	0	5	10										A	18234408	G	A	18234408	2	1	122	1	0	0	0	0	0	0	0	1	9326	1161	41	1		1	MAST3	19	18234408	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	241552	18234408	40894575	156	36750										
PDCD2L	84306	broad.mit.edu	37	chr19	34895679	34895679	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	caccgtctgctgcacgtgttCgcgtgcgcctgccccggctg	13	17	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:34895679C>T	uc002nvj.2	+	2	267	c.234C>T	c.(232-234)TTC>TTT	p.F78F		NM_032346	NP_115722	Q9BRP1	PDD2L_HUMAN	programmed cell death 2-like	78						cytoplasm				ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TGCACGTGTTCGCGTGCGCCT	0.711													0	0	0	0.09319	0	10	10										T	34895679	C	T	34895679	2	4	122	1	0	0	0	0	0	0	0	1	11620	883	31	1		1	PDCD2L	19	34895679	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	16661271	34895679	24233304	157	36751										
ZNF223	7766	broad.mit.edu	37	chr19	44564985	44564985	+	Frame_Shift_Del	DEL	G	G	-													0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atatagcaacccaaagggaaGggaattcaggtaagaagcac							TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:44564985delG	uc002oyf.1	+	4	479	c.226delG	c.(226-228)GGGfs	p.G76fs	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	76	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				CCAAAGGGAAGGGAATTCAGG	0.338																		46	146	---	---								-	44564985	G	-	44564985	7	5	122	1	0	1	0	1	0	0	0	0	17774	1000	35	0	236	0	ZNF223	19	44564985	Frame_Shift_Del	DEL	G	TCGA-GV-A3QK-01B-11D-A23M-08	9669306	44564985	14563998	158	36752										
ZNF841	284371	broad.mit.edu	37	chr19	52568806	52568806	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atgacgtgcgaggcctgagcGataacggaagaccttgccac	13	11	0	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:52568806G>A	uc002pyl.1	-	5	2533	c.1981C>T	c.(1981-1983)CGC>TGC	p.R661C	ZNF841_uc010ydh.1_Missense_Mutation_p.R777C|ZNF841_uc010epk.1_Missense_Mutation_p.R353C	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	661	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGCCTGAGCGATAACGGAAG	0.428													0	0	0	0.020292	0	15	29										A	52568806	G	A	52568806	3	1	122	1	0	0	0	0	1	0	0	0	18186	1058	37	1	449	1	ZNF841	19	52568806	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	8003821	52568806	6560177	159	36753										
LAIR1	3903	broad.mit.edu	37	chr19	54871634	54871634	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggccctgctactgaccagctGaggagccgggctctgtgtcc	14	14	1	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:54871634G>A	uc002qfk.1	-	4	720	c.410C>T	c.(409-411)TCA>TTA	p.S137L	LAIR1_uc002qfl.1_Intron|LAIR1_uc002qfm.1_Missense_Mutation_p.S136L|LAIR1_uc002qfn.1_Intron|LAIR1_uc010yex.1_Missense_Mutation_p.S130L|LAIR1_uc002qfo.2_Missense_Mutation_p.S119L	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	leukocyte-associated immunoglobulin-like	137	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity			ovary(4)	4	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CTGACCAGCTGAGGAGCCGGG	0.627													0	0	0	0.024245	0	12	30										A	54871634	G	A	54871634	3	1	122	1	0	0	0	0	1	0	0	0	8602	1294	45	1	481	1	LAIR1	19	54871634	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	2302828	54871634	4257349	160	36754										
NLRP2	55655	broad.mit.edu	37	chr19	55512138	55512138	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgtaccccaggttgaaaatcGatgactttaatgatgaactc	8	8	0	4	rs144393067		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr19:55512138G>C	uc002qij.2	+	13	3147	c.3061G>C	c.(3061-3063)GAT>CAT	p.D1021H	NLRP2_uc010yfp.1_Missense_Mutation_p.D998H|NLRP2_uc010esn.2_Missense_Mutation_p.D997H|NLRP2_uc010eso.2_Missense_Mutation_p.D1018H|NLRP2_uc010esp.2_Missense_Mutation_p.D999H	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1021	LRR 8.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTTGAAAATCGATGACTTTAA	0.393													0	0	0	0.09836	0	36	53										C	55512138	G	C	55512138	3	2	122	1	0	0	0	0	1	0	0	0	10477	1058	37	1	3107	1	NLRP2	19	55512138	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	640504	55512138	3616845	161	36755										
CSNK2A1	1457	broad.mit.edu	37	chr20	472991	472991	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgataaaactcagccaaaccCcagtctattagtcgtagctg	7	11	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:472991C>T	uc002wdw.1	-	9	921	c.528G>A	c.(526-528)TGG>TGA	p.W176*	CSNK2A1_uc002wdx.1_Nonsense_Mutation_p.W176*|CSNK2A1_uc002wdy.1_Nonsense_Mutation_p.W40*	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	176	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CAGCCAAACCCCAGTCTATTA	0.393													0	0	0	0.080935	0	11	43										T	472991	C	T	472991	4	4	122	1	0	0	0	0	0	1	0	0	3957	624	22	2	671	2	CSNK2A1	20	472991	Nonsense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		472991	62552529	162	36756										
PIGU	128869	broad.mit.edu	37	chr20	33162908	33162908	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ccccatgctgtccctcttacCtgcccaacgttgaaggtcag	8	16	2	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:33162908C>T	uc002xas.2	-	11	1394	c.1194G>A	c.(1192-1194)CAG>CAA	p.Q398Q	PIGU_uc010zul.1_Silent_p.Q398Q|PIGU_uc002xat.2_Silent_p.Q378Q	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	398	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0						TCCCTCTTACCTGCCCAACGT	0.483													0	0	0	0.086207	0	37	81										T	33162908	C	T	33162908	2	4	122	1	0	0	0	0	0	0	0	1	11900	695	24	2		2	PIGU	20	33162908	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	32689917	33162908	29862612	163	36757										
TGM2	7052	broad.mit.edu	37	chr20	36760817	36760817	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctgttgataactggctccacGaggagggcccgcaccttgat	12	12	0	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:36760817G>A	uc002xhr.2	-	11	1801	c.1701C>T	c.(1699-1701)CTC>CTT	p.L567L	TGM2_uc002xhq.2_Silent_p.L168L|TGM2_uc010zvx.1_Silent_p.L486L|TGM2_uc010zvy.1_Silent_p.L507L|TGM2_uc002xhs.1_Silent_p.L543L	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	567					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	CTGGCTCCACGAGGAGGGCCC	0.557													0	0	0	0.048971	0	93	216										A	36760817	G	A	36760817	2	1	122	1	0	0	0	0	0	0	0	1	15827	1045	37	1		1	TGM2	20	36760817	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3597909	36760817	26264703	164	36758										
KCNB1	3745	broad.mit.edu	37	chr20	47991418	47991418	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ctccacgtgggccagctgggGgttgtctgtggactggccga	17	11	1	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:47991418G>A	uc002xur.1	-	2	843	c.679C>T	c.(679-681)CCC>TCC	p.P227S	KCNB1_uc002xus.1_Missense_Mutation_p.P227S	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	227					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GCCAGCTGGGGGTTGTCTGTG	0.572													0	0	0	0.041601	0	31	41										A	47991418	G	A	47991418	3	1	122	1	0	0	0	0	1	0	0	0	8012	1232	43	2	1901	2	KCNB1	20	47991418	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	11230601	47991418	15034102	165	36759										
DIDO1	11083	broad.mit.edu	37	chr20	61541160	61541160	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gctctattgttcctatacttGtacaatcggtgccatcagca	7	11	2	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr20:61541160G>A	uc002ydr.1	-	4	1316	c.1052C>T	c.(1051-1053)ACA>ATA	p.T351I	DIDO1_uc002yds.1_Missense_Mutation_p.T351I|DIDO1_uc002ydt.1_Missense_Mutation_p.T351I|DIDO1_uc002ydu.1_Missense_Mutation_p.T351I|DIDO1_uc002ydv.1_Missense_Mutation_p.T351I|DIDO1_uc002ydw.1_Missense_Mutation_p.T351I|DIDO1_uc002ydx.1_Missense_Mutation_p.T351I|DIDO1_uc011aao.1_Missense_Mutation_p.T351I	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	351					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TCCTATACTTGTACAATCGGT	0.453													0	0	0	0.048971	0	69	102										A	61541160	G	A	61541160	3	1	122	1	0	0	0	0	1	0	0	0	4522	1377	48	2	5852	2	DIDO1	20	61541160	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	13549742	61541160	1484360	166	36760										
KRTAP19-2	337969	broad.mit.edu	37	chr21	31859546	31859546	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	atctatatcttctgtagcatGatgggcagcagcagccatct	9	10	4	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:31859546G>T	uc011acy.1	-	1	122	c.122C>A	c.(121-123)TCA>TAA	p.S41*		NM_181608	NP_853639	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	41						intermediate filament					0						TCTGTAGCATGATGGGCAGCA	0.453													1	0	2.08937e-45	0.048971	2.30589e-45	78	138										T	31859546	G	T	31859546	4	4	122	1	0	0	0	0	0	1	0	0	8529	1294	45	3	38	3	KRTAP19-2	21	31859546	Nonsense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		31859546	16270349	167	36761										
SLC5A3	6526	broad.mit.edu	37	chr21	35468622	35468622	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gcagtgatgattgcagctctGatgagtgacttagactctat	11	7	2	6			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:35468622G>C	uc002yto.2	+	2	1637	c.1125G>C	c.(1123-1125)CTG>CTC	p.L375L	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	375	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						TTGCAGCTCTGATGAGTGACT	0.493													0	0	0	0.0918	0	24	45										C	35468622	G	C	35468622	2	2	122	1	0	0	0	0	0	0	0	1	14666	1277	45	1		1	SLC5A3	21	35468622	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3609076	35468622	12661273	168	36762										
RRP1B	23076	broad.mit.edu	37	chr21	45106729	45106729	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ttgcggaggacatttctgctGatgaagatgaccaaatcctc	10	9	1	4			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr21:45106729G>T	uc002zdk.2	+	12	1168	c.1054G>T	c.(1054-1056)GAT>TAT	p.D352Y	RRP1B_uc002zdl.2_5'UTR	NM_015056	NP_055871	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1 homolog B	352					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.178)		CATTTCTGCTGATGAAGATGA	0.428													1	0	2.47316e-13	0.059317	2.59499e-13	35	84										T	45106729	G	T	45106729	3	4	122	1	0	0	0	0	1	0	0	0	13688	1290	45	3	1100	3	RRP1B	21	45106729	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	9638107	45106729	3023166	169	36763										
ASCC2	84164	broad.mit.edu	37	chr22	30200815	30200815	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gatgtaggcagtccgcgtctCgtccctgtgaggacttgtta	13	10	1	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr22:30200815C>T	uc003agr.2	-	13	1270	c.1165G>A	c.(1165-1167)GAG>AAG	p.E389K	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Missense_Mutation_p.E389K|ASCC2_uc011akr.1_Missense_Mutation_p.E313K	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GTCCGCGTCTCGTCCCTGTGA	0.547													0	0	0	0.048971	0	97	315										T	30200815	C	T	30200815	3	4	122	1	0	0	0	0	1	0	0	0	1032	893	31	1	1140	1	ASCC2	22	30200815	Missense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08		30200815	21103751	170	36764										
IL2RB	3560	broad.mit.edu	37	chr22	37524480	37524480	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggcagtgcttggggggctggGgccaccgaggagactggggg	23	8	0	1			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chr22:37524480G>C	uc003aqv.1	-	10	1443	c.1312C>G	c.(1312-1314)CCC>GCC	p.P438A		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	438	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GGGGGGCTGGGGCCACCGAGG	0.672													0	0	0	0.076483	0	23	23										C	37524480	G	C	37524480	3	2	122	1	0	0	0	0	1	0	0	0	7687	1232	43	4	347	4	IL2RB	22	37524480	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	7323665	37524480	13780086	171	36765										
FAM9B	171483	broad.mit.edu	37	chrX	8997436	8997436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	ggacatttagcaacttcagaGaatgtatataatcacgtttc	7	7	2	1	rs12839241		TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:8997436G>A	uc011mhu.1	-	5	394	c.305C>T	c.(304-306)TCT>TTT	p.S102F	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Missense_Mutation_p.S142F	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	102						nucleus					0		Hepatocellular(5;0.219)				CAACTTCAGAGAATGTATATA	0.294													0	0	0	0.09319	0	12	36										A	8997436	G	A	8997436	3	1	122	1	0	0	0	0	1	0	0	0	5660	942	33	1	267	1	FAM9B	23	8997436	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08		8997436	146273124	172	36766										
TSPAN6	7105	broad.mit.edu	37	chrX	99888429	99888429	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tttactttgtctgcatctctCtgtggagtacaatcttcaag	7	9	5	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:99888429C>T	uc004ega.1	-	5	661	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	TSPAN6_uc010nna.1_Silent_p.Q92Q	NM_003270	NP_003261	O43657	TSN6_HUMAN	transmembrane 4 superfamily member 6	186	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			ovary(1)	1						CTGCATCTCTCTGTGGAGTAC	0.338													0	0	0	0.037714	0	29	19										T	99888429	C	T	99888429	2	4	122	1	0	0	0	0	0	0	0	1	16648	912	32	1		1	TSPAN6	23	99888429	Silent	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	90890993	99888429	55382131	173	36767										
LAMP2	3920	broad.mit.edu	37	chrX	119589270	119589270	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gtgttgtaggaaaatgagacGctgtcaattgaataagtaga	12	3	1	3	rs147369153	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:119589270G>A	uc004est.3	-	3	519	c.339C>T	c.(337-339)AGC>AGT	p.S113S	LAMP2_uc004ess.3_Silent_p.S113S|LAMP2_uc011mtz.1_Intron|LAMP2_uc011mua.1_Silent_p.S66S|LAMP2_uc010nqp.1_Silent_p.S113S	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	113	Lumenal (Potential).|First lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						AAAATGAGACGCTGTCAATTG	0.403													0	0	0	0.064281	0	35	24										A	119589270	G	A	119589270	2	1	122	1	0	0	0	0	0	0	0	1	8618	1078	38	2		2	LAMP2	23	119589270	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	19700841	119589270	35681290	174	36768										
MAGEC1	9947	broad.mit.edu	37	chrX	140993238	140993238	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	gggatgccgagtcttctccaGagttcctctgagagtcctca	11	12	4	2			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:140993238G>C	uc004fbt.2	+	4	334	c.48G>C	c.(46-48)CAG>CAC	p.Q16H	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	16							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GTCTTCTCCAGAGTTCCTCTG	0.463										HNSCC(15;0.026)			0	0	0	0.039052	0	45	48										C	140993238	G	C	140993238	3	2	122	1	0	0	0	0	1	0	0	0	9180	933	33	1	54	1	MAGEC1	23	140993238	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	21403968	140993238	14277322	175	36769										
MAGEC1	9947	broad.mit.edu	37	chrX	140995384	140995384	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	actttcctcagtttcctcctCagggggaggacttccagtct	9	13	3	0			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:140995384C>T	uc004fbt.2	+	4	2480	c.2194C>T	c.(2194-2196)CAG>TAG	p.Q732*	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	732							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTCCTCCTCAGGGGGAGGA	0.542										HNSCC(15;0.026)			0	0	0	0.048971	0	100	84										T	140995384	C	T	140995384	4	4	122	1	0	0	0	0	0	1	0	0	9180	827	29	1	2200	1	MAGEC1	23	140995384	Nonsense_Mutation	SNP	C	TCGA-GV-A3QK-01B-11D-A23M-08	2146	140995384	14275176	176	36770										
MTMR1	8776	broad.mit.edu	37	chrX	149900044	149900044	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	tgccaactagtgtaaaagatGatgacctttcaaaagtggca	9	7	1	3			TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:149900044G>A	uc004fei.2	+	8	955	c.820G>A	c.(820-822)GAT>AAT	p.D274N	MTMR1_uc011mya.1_Missense_Mutation_p.D180N|MTMR1_uc004feg.1_Missense_Mutation_p.D274N|MTMR1_uc004feh.1_Missense_Mutation_p.D282N|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	274	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TGTAAAAGATGATGACCTTTC	0.358													0	0	0	0.048971	0	52	30										A	149900044	G	A	149900044	3	1	122	1	0	0	0	0	1	0	0	0	9938	1290	45	1	850	1	MTMR1	23	149900044	Missense_Mutation	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	8904660	149900044	5370516	177	36771										
DUSP9	1852	broad.mit.edu	37	chrX	152915679	152915679	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.295454545454545	52	3.78005363573693e-14	3.11434081829453	4.94971537001898	2.48910333364115	0.0901326460466097	0.216985999741838	35	caggagcagggcagtgggggGcaggcatctgcggcctccaa	18	11	1	0	rs139744131	byFrequency	TCGA-GV-A3QK-01B-11D-A23M-08	TCGA-GV-A3QK-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bba535e3-c48a-4b50-af45-409c099d5be0	b833e093-cd12-441b-9791-fdd25c031925	g.chrX:152915679G>T	uc004fhx.3	+	4	1278	c.1074G>T	c.(1072-1074)GGG>GGT	p.G358G	DUSP9_uc004fhy.3_Silent_p.G358G	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	358	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGTGGGGGGCAGGCATCTG	0.672													1	0	0.00198382	0.02938	0.00199318	7	117										T	152915679	G	T	152915679	2	4	122	1	0	0	0	0	0	0	0	1	4832	1190	42	4		4	DUSP9	23	152915679	Silent	SNP	G	TCGA-GV-A3QK-01B-11D-A23M-08	3015635	152915679	2354881	178	36772										
MFN2	9927	broad.mit.edu	37	chr1	12065806	12065806	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttcctgtgtctgtgcggagtCagatagacatgctggtccca	12	10	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:12065806C>G	uc001atn.3	+	15	1987	c.1534C>G	c.(1534-1536)CAG>GAG	p.Q512E	MFN2_uc009vni.2_Missense_Mutation_p.Q512E	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	512	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TGTGCGGAGTCAGATAGACAT	0.512													0	0	0	0.00361	0	78	287										G	12065806	C	G	12065806	3	3	123	1	0	0	0	0	1	0	0	0	9524	827	29	1	1584	1	MFN2	1	12065806	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08		12065806	237184815	1	36773										
EYA3	2140	broad.mit.edu	37	chr1	28362171	28362171	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cagtttccgaaacaggaactGagagaatatgtgcataaggt	11	6	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:28362171G>C	uc001bpi.1	-	6	410	c.245C>G	c.(244-246)TCA>TGA	p.S82*	EYA3_uc010ofs.1_Nonsense_Mutation_p.S29*|EYA3_uc010oft.1_Nonsense_Mutation_p.S82*|EYA3_uc001bpj.2_Nonsense_Mutation_p.S82*|EYA3_uc001bpk.1_RNA|EYA3_uc010ofu.1_RNA	NM_001990	NP_001981	Q99504	EYA3_HUMAN	eyes absent 3	82					anatomical structure morphogenesis|double-strand break repair|histone dephosphorylation|multicellular organismal development|positive regulation of DNA repair|regulation of transcription, DNA-dependent|response to ionizing radiation|transcription, DNA-dependent|visual perception	cytoplasm	metal ion binding|protein binding|protein tyrosine phosphatase activity			ovary(2)|skin(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000432)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0484)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;2.8e-06)|STAD - Stomach adenocarcinoma(196;0.00364)|KIRC - Kidney renal clear cell carcinoma(1967;0.00378)|BRCA - Breast invasive adenocarcinoma(304;0.00718)|READ - Rectum adenocarcinoma(331;0.0642)		AACAGGAACTGAGAGAATATG	0.398													0	0	0	0.001984	0	7	134										C	28362171	G	C	28362171	4	2	123	1	0	0	0	0	0	1	0	0	5330	1294	45	1	1528	1	EYA3	1	28362171	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	16296365	28362171	220888450	2	36774										
PHACTR4	65979	broad.mit.edu	37	chr1	28817515	28817515	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cgagaaattaaacgtcggctCactagaaaggtactactgcc	9	10	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:28817515C>G	uc001bpw.2	+	11	2151	c.1869C>G	c.(1867-1869)CTC>CTG	p.L623L	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Silent_p.L607L|PHACTR4_uc001bpy.2_Silent_p.L633L|PHACTR4_uc001bpz.2_5'Flank	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	623	RPEL 3.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		AACGTCGGCTCACTAGAAAGG	0.333													0	0	0	0.004482	0	9	74										G	28817515	C	G	28817515	2	3	123	1	0	0	0	0	0	0	0	1	11812	813	29	1		1	PHACTR4	1	28817515	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	455344	28817515	220433106	3	36775										
KDM4A	9682	broad.mit.edu	37	chr1	44156655	44156655	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	catcaacctttctactccttAtcttgaggaggatggcacca	7	12	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:44156655A>T	uc001cjx.2	+	14	2343	c.2177A>T	c.(2176-2178)TAT>TTT	p.Y726F	KDM4A_uc010oki.1_Intron	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	726	PHD-type 1.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						TCTACTCCTTATCTTGAGGAG	0.532													0	0	0	0.00361	0	60	379										T	44156655	A	T	44156655	3	4	123	1	0	0	0	0	1	0	0	0	8128	449	16	5	2227	5	KDM4A	1	44156655	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	15339140	44156655	205093966	4	36776										
DENND2C	163259	broad.mit.edu	37	chr1	115168392	115168392	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	attttcacggctggttacatCcaagtttttgctctttctct	6	10	3	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:115168392C>T	uc001efd.1	-	4	916	c.214G>A	c.(214-216)GAT>AAT	p.D72N	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Missense_Mutation_p.D72N	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	72										skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGTTACATCCAAGTTTTTG	0.363													0	0	0	0.003954	0	26	171										T	115168392	C	T	115168392	3	4	123	1	0	0	0	0	1	0	0	0	4430	855	30	1	2469	1	DENND2C	1	115168392	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	71011737	115168392	134082229	5	36777										
FLG2	388698	broad.mit.edu	37	chr1	152323576	152323576	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	catagtgggcatgtctagtgGtatctcctgtctgtccatga	11	9	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:152323576G>A	uc001ezw.3	-	3	6759	c.6686C>T	c.(6685-6687)ACC>ATC	p.T2229I	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2229							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGTCTAGTGGTATCTCCTGT	0.527													0	0	0	0.00361	0	203	475										A	152323576	G	A	152323576	3	1	123	1	0	0	0	0	1	0	0	0	5923	1261	44	2	493	2	FLG2	1	152323576	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	37155184	152323576	96927045	6	36778										
FLG2	388698	broad.mit.edu	37	chr1	152325626	152325626	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tctagtggtatctcctgtctGtccatgagtaattctgtgtc	9	9	4	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:152325626G>T	uc001ezw.3	-	3	4709	c.4636C>A	c.(4636-4638)CAG>AAG	p.Q1546K	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1546							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCCTGTCTGTCCATGAGTA	0.483													1	0	7.82978e-24	0.00361	8.90638e-24	65	434										T	152325626	G	T	152325626	3	4	123	1	0	0	0	0	1	0	0	0	5923	1386	48	4	2543	4	FLG2	1	152325626	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	2050	152325626	96924995	7	36779										
PBXIP1	57326	broad.mit.edu	37	chr1	154920741	154920741	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agccaggggcaccatgggctGaggtgggccggcctcccggc	18	14	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:154920741G>C	uc001ffr.2	-	6	570	c.511C>G	c.(511-513)CAG>GAG	p.Q171E	PBXIP1_uc001ffs.2_Missense_Mutation_p.Q142E|PBXIP1_uc010pep.1_Missense_Mutation_p.Q16E	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	171					cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ACCATGGGCTGAGGTGGGCCG	0.692													0	0	0	0.001168	0	5	13										C	154920741	G	C	154920741	3	2	123	1	0	0	0	0	1	0	0	0	11496	1299	45	1	1708	1	PBXIP1	1	154920741	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	2595115	154920741	94329880	8	36780										
ZBTB7B	51043	broad.mit.edu	37	chr1	154988787	154988787	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cccgcttcctgcacagctacGacctcaagaaccacatgcac	6	18	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:154988787G>A	uc001fgk.3	+	4	1404	c.1246G>A	c.(1246-1248)GAC>AAC	p.D416N	ZBTB7B_uc009wpa.2_Missense_Mutation_p.D416N|ZBTB7B_uc001fgj.3_Missense_Mutation_p.D450N|ZBTB7B_uc010peq.1_Missense_Mutation_p.D450N|ZBTB7B_uc001fgl.3_Missense_Mutation_p.D416N	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	416	C2H2-type 3.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACAGCTACGACCTCAAGAA	0.627													0	0	0	0.008361	0	32	91										A	154988787	G	A	154988787	3	1	123	1	0	0	0	0	1	0	0	0	17551	1058	37	1	1252	1	ZBTB7B	1	154988787	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	68046	154988787	94261834	9	36781										
DPM3	54344	broad.mit.edu	37	chr1	155112686	155112686	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggtggagcccaggatcgctaGtccccaaagccactgcgcta	12	14	0	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:155112686G>A	uc001fhn.2	-	2	66	c.31C>T	c.(31-33)CTA>TTA	p.L11L	RAG1AP1_uc010pey.1_Intron|DPM3_uc001fhm.2_Silent_p.L41L	NM_153741	NP_714963	Q9P2X0	DPM3_HUMAN	dolichyl-phosphate mannosyltransferase	11	Helical; (Potential).				C-terminal protein lipidation|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|protein N-linked glycosylation via asparagine|protein O-linked mannosylation|regulation of protein stability	dolichol-phosphate-mannose synthase complex|integral to endoplasmic reticulum membrane	protein binding				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGGATCGCTAGTCCCCAAAGC	0.478													0	0	0	0.002836	0	32	43										A	155112686	G	A	155112686	2	1	123	1	0	0	0	0	0	0	0	1	4726	1020	36	2		2	DPM3	1	155112686	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	123899	155112686	94137935	10	36782										
PAPPA2	60676	broad.mit.edu	37	chr1	176525600	176525600	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atcaggtgctgttggaaggaGaacgttgttggctgggggcc	18	6	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:176525600G>A	uc001gkz.2	+	2	1306	c.142G>A	c.(142-144)GAA>AAA	p.E48K	PAPPA2_uc001gky.1_Missense_Mutation_p.E48K|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	48					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GTTGGAAGGAGAACGTTGTTG	0.572													0	0	0	0.00308	0	7	152										A	176525600	G	A	176525600	3	1	123	1	0	0	0	0	1	0	0	0	11433	943	33	1	144	1	PAPPA2	1	176525600	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	21412914	176525600	72725021	11	36783										
FAM5C	339479	broad.mit.edu	37	chr1	190068168	190068168	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	accacctggtcattcggacaCgtgcacgagtgcgtctcttc	10	14	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:190068168C>T	uc001gse.1	-	8	1513	c.1281G>A	c.(1279-1281)ACG>ACA	p.T427T	FAM5C_uc010pot.1_Silent_p.T325T	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	427						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CATTCGGACACGTGCACGAGT	0.587													0	0	0	0.000602	0	4	58										T	190068168	C	T	190068168	2	4	123	1	0	0	0	0	0	0	0	1	5594	523	19	2		2	FAM5C	1	190068168	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13542568	190068168	59182453	12	36784										
TTC13	79573	broad.mit.edu	37	chr1	231060618	231060618	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aactgcaatgtcaaacatgtCtctccactgcatcaaccgtg	6	13	3	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:231060618C>G	uc001huf.3	-	14	1721	c.1690G>C	c.(1690-1692)GAC>CAC	p.D564H	TTC13_uc009xfi.2_Missense_Mutation_p.D511H|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.D511H|TTC13_uc009xfk.1_Missense_Mutation_p.D454H	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	564							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TCAAACATGTCTCTCCACTGC	0.423													0	0	0	0.007291	0	27	164										G	231060618	C	G	231060618	3	3	123	1	0	0	0	0	1	0	0	0	16677	913	32	1	932	1	TTC13	1	231060618	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	40992450	231060618	18190003	13	36785										
SIPA1L2	57568	broad.mit.edu	37	chr1	232649719	232649719	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctctgggcacttccaagacgGagacacctgcatttgtgcag	11	12	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:232649719G>C	uc001hvg.2	-	1	1525	c.1367C>G	c.(1366-1368)TCC>TGC	p.S456C		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	456					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTCCAAGACGGAGACACCTGC	0.498													0	0	0	0.005443	0	26	210										C	232649719	G	C	232649719	3	2	123	1	0	0	0	0	1	0	0	0	14330	1174	41	1	3885	1	SIPA1L2	1	232649719	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1589101	232649719	16600902	14	36786										
FMN2	56776	broad.mit.edu	37	chr1	240370532	240370532	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ccatcagcccacacagagcaTctcacagcctccaccacctc	4	21	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:240370532T>C	uc010pyd.1	+	5	2645	c.2420T>C	c.(2419-2421)ATC>ACC	p.I807T	FMN2_uc010pye.1_Missense_Mutation_p.I811T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	807	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			ACACAGAGCATCTCACAGCCT	0.527													0	0	0	0.000602	0	5	92										C	240370532	T	C	240370532	3	2	123	1	0	0	0	0	1	0	0	0	5950	1435	50	5	2438	5	FMN2	1	240370532	Missense_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	7720813	240370532	8880089	15	36787										
ZNF695	57116	broad.mit.edu	37	chr1	247151507	247151507	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	catcactttttggaatgaaaCttgcaggccctgctctggca	9	11	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr1:247151507C>A	uc009xgu.2	-	4	455	c.310G>T	c.(310-312)GTT>TTT	p.V104F	ZNF695_uc001ica.2_RNA|ZNF695_uc001icb.1_RNA|ZNF695_uc009xgt.1_RNA|ZNF695_uc001ibx.2_Missense_Mutation_p.V104F|ZNF695_uc001iby.2_Intron|ZNF695_uc001icc.2_Missense_Mutation_p.V92F	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	104					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGGAATGAAACTTGCAGGCCC	0.373													1	0	6.57855e-14	0.009718	7.33038e-14	45	111										A	247151507	C	A	247151507	3	1	123	1	0	0	0	0	1	0	0	0	18095	565	20	4	1241	4	ZNF695	1	247151507	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	6780975	247151507	2099114	16	36788										
ASAP2	8853	broad.mit.edu	37	chr2	9498900	9498900	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggcagatcctacatggctttCcaccaacctgggcatcctga	9	14	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:9498900C>A	uc002qzh.2	+	15	1683	c.1343C>A	c.(1342-1344)TCC>TAC	p.S448Y	ASAP2_uc002qzi.2_Missense_Mutation_p.S448Y	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	448	Arf-GAP.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						ACATGGCTTTCCACCAACCTG	0.498													1	0	4.75955e-12	0.00361	5.23934e-12	48	321										A	9498900	C	A	9498900	3	1	123	1	0	0	0	0	1	0	0	0	1011	855	30	3	1401	3	ASAP2	2	9498900	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08		9498900	233700473	17	36789										
ROCK2	9475	broad.mit.edu	37	chr2	11355053	11355053	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aagattgataaattccttttCaagttttaacttggcagtct	6	6	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:11355053C>G	uc002rbd.1	-	16	2298	c.1849G>C	c.(1849-1851)GAA>CAA	p.E617Q		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	617	Potential.|Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AATTCCTTTTCAAGTTTTAAC	0.383													0	0	0	0.001168	0	6	94										G	11355053	C	G	11355053	3	3	123	1	0	0	0	0	1	0	0	0	13518	835	29	1	2389	1	ROCK2	2	11355053	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1856153	11355053	231844320	18	36790										
NT5C1B	93034	broad.mit.edu	37	chr2	18757543	18757543	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgttcagactcatcagagaaGaggacagcatccccatcaaa	8	11	4	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:18757543G>A	uc002rcz.2	-	9	1520	c.1416C>T	c.(1414-1416)CTC>CTT	p.L472L	NT5C1B_uc002rcy.2_Silent_p.L472L|NT5C1B_uc010exr.2_Silent_p.L414L|NT5C1B_uc010yju.1_Silent_p.L412L|NT5C1B_uc002rda.2_Silent_p.L412L|NT5C1B_uc010yjv.1_Silent_p.L489L|NT5C1B_uc010yjw.1_Silent_p.L455L|NT5C1B_uc010exs.2_Silent_p.L474L	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	472					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CATCAGAGAAGAGGACAGCAT	0.453													0	0	0	0.001168	0	5	83										A	18757543	G	A	18757543	2	1	123	1	0	0	0	0	0	0	0	1	10686	929	33	1		1	NT5C1B	2	18757543	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	7402490	18757543	224441830	19	36791										
SIX2	10736	broad.mit.edu	37	chr2	45233476	45233476	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cagggacggcagcccaggggGcggcgggctgaggagcagtg	22	10	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:45233476G>A	uc002ruo.2	-	2	1002	c.709C>T	c.(709-711)CCC>TCC	p.P237S	SIX2_uc002rup.2_Missense_Mutation_p.P239S	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	237						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCCCAGGGGGCGGCGGGCTG	0.701													0	0	0	0.00499	0	16	140										A	45233476	G	A	45233476	3	1	123	1	0	0	0	0	1	0	0	0	14347	1203	42	2	170	2	SIX2	2	45233476	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	26475933	45233476	197965897	20	36792										
TSPYL6	388951	broad.mit.edu	37	chr2	54482756	54482756	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgtttacctcatctattgctCtgttttcttccgccacgtcc	5	14	4	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:54482756C>G	uc002rxr.2	-	1	654	c.533G>C	c.(532-534)AGA>ACA	p.R178T	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	178					nucleosome assembly	nucleus					0						ATCTATTGCTCTGTTTTCTTC	0.617													0	0	0	0.004007	0	15	166										G	54482756	C	G	54482756	3	3	123	1	0	0	0	0	1	0	0	0	16660	913	32	1	703	1	TSPYL6	2	54482756	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	9249280	54482756	188716617	21	36793										
MCEE	84693	broad.mit.edu	37	chr2	71337220	71337220	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgcggatcttcttttttttCaaatccatcacagctgcatt	5	11	4	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:71337220C>G	uc002shs.2	-	3	456	c.411G>C	c.(409-411)TTG>TTC	p.L137F		NM_032601	NP_115990	Q96PE7	MCEE_HUMAN	methylmalonyl CoA epimerase precursor	137					fatty acid beta-oxidation|L-methylmalonyl-CoA metabolic process	mitochondrial matrix	methylmalonyl-CoA epimerase activity			ovary(1)	1						TCTTTTTTTTCAAATCCATCA	0.333													0	0	0	0.006214	0	8	42										G	71337220	C	G	71337220	3	3	123	1	0	0	0	0	1	0	0	0	9377	825	29	1	123	1	MCEE	2	71337220	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	16854464	71337220	171862153	22	36794										
FBXO41	150726	broad.mit.edu	37	chr2	73493771	73493771	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttggcgctggcctcccgcgcCgccgtctccttcaggaactg	12	17	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:73493771C>T	uc002sjb.1	-	3	1128	c.1128G>A	c.(1126-1128)GCG>GCA	p.A376A		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	315	Potential.					intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						CCTCCCGCGCCGCCGTCTCCT	0.667													0	0	0	0.00308	0	7	77										T	73493771	C	T	73493771	2	4	123	1	0	0	0	0	0	0	0	1	5750	639	23	2		2	FBXO41	2	73493771	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	2156551	73493771	169705602	23	36795										
C2orf3	6936	broad.mit.edu	37	chr2	75917840	75917840	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tccacttgtggatgtctcatCtttgcctgttaataaataaa	6	8	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:75917840C>T	uc002sno.2	-	8	1280	c.1150G>A	c.(1150-1152)GAT>AAT	p.D384N	C2orf3_uc010ffs.2_5'UTR|C2orf3_uc002snn.2_Missense_Mutation_p.D215N|C2orf3_uc010fft.2_Missense_Mutation_p.D59N	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	384					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GATGTCTCATCTTTGCCTGTT	0.289													0	0	0	0.007413	0	19	163										T	75917840	C	T	75917840	3	4	123	1	0	0	0	0	1	0	0	0	2162	913	32	1	1235	1	C2orf3	2	75917840	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	2424069	75917840	167281533	24	36796										
LRP2	4036	broad.mit.edu	37	chr2	170063207	170063207	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tccaagcaagggttgttgttGacctctgctggtgaccgggg	15	9	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:170063207G>C	uc002ues.2	-	39	7236	c.7023C>G	c.(7021-7023)GTC>GTG	p.V2341V		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2341	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGTTGTTGTTGACCTCTGCTG	0.507													0	0	0	0.006214	0	9	59										C	170063207	G	C	170063207	2	2	123	1	0	0	0	0	0	0	0	1	8956	1277	45	1		1	LRP2	2	170063207	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	94145367	170063207	73136166	25	36797										
AGPS	8540	broad.mit.edu	37	chr2	178346824	178346824	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	acagaagctacaataaaaatCagaccagtccctgaatacca	5	11	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:178346824C>G	uc002ull.2	+	11	1190	c.1143C>G	c.(1141-1143)ATC>ATG	p.I381M	AGPS_uc010zfb.1_Missense_Mutation_p.I291M	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	381	FAD-binding PCMH-type.				ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			CAATAAAAATCAGACCAGTCC	0.338													0	0	0	0.008291	0	10	47										G	178346824	C	G	178346824	3	3	123	1	0	0	0	0	1	0	0	0	394	816	29	1	1185	1	AGPS	2	178346824	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	8283617	178346824	64852549	26	36798										
TTN	7273	broad.mit.edu	37	chr2	179474920	179474920	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aagtattcaccatttggtatGagatccttcacagtccatga	7	9	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:179474920G>T	uc010zfg.1	-	220	43853	c.43629C>A	c.(43627-43629)CTC>CTA	p.L14543L	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L8238L|TTN_uc010zfi.1_Silent_p.L8171L|TTN_uc010zfj.1_Silent_p.L8046L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15470							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTTGGTATGAGATCCTTCA	0.418													1	0	5.61819e-17	0.005443	6.33787e-17	27	220										T	179474920	G	T	179474920	2	4	123	1	0	0	0	0	0	0	0	1	16732	1277	45	3		3	TTN	2	179474920	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1128096	179474920	63724453	27	36799										
TTN	7273	broad.mit.edu	37	chr2	179640747	179640747	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cctggttcatgtacgtgaaaCtcaggccttggttcaggagc	12	10	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:179640747C>G	uc010zfg.1	-	28	6068	c.5844G>C	c.(5842-5844)GAG>GAC	p.E1948D	TTN_uc010zfh.1_Missense_Mutation_p.E1902D|TTN_uc010zfi.1_Missense_Mutation_p.E1902D|TTN_uc010zfj.1_Missense_Mutation_p.E1902D|TTN_uc002unb.2_Missense_Mutation_p.E1948D|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1948							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACGTGAAACTCAGGCCTTG	0.423													0	0	0	0.008871	0	18	261										G	179640747	C	G	179640747	3	3	123	1	0	0	0	0	1	0	0	0	16732	564	20	4	105484	4	TTN	2	179640747	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	165827	179640747	63558626	28	36800										
NCKAP1	10787	broad.mit.edu	37	chr2	183817542	183817542	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgatatgtcagaatattcctCtgcattgaatgttaattcat	6	6	3	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:183817542C>T	uc002upc.2	-	22	2884	c.2482G>A	c.(2482-2484)GAG>AAG	p.E828K	NCKAP1_uc002upb.2_Missense_Mutation_p.E834K	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	828					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GAATATTCCTCTGCATTGAAT	0.338													0	0	0	0.008291	0	9	44										T	183817542	C	T	183817542	3	4	123	1	0	0	0	0	1	0	0	0	10221	922	32	1	944	1	NCKAP1	2	183817542	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	4176795	183817542	59381831	29	36801										
PMS1	5378	broad.mit.edu	37	chr2	190728630	190728630	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	caagttaaaaacctcattatCtaatcaaccaaaacttgatg	3	9	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:190728630C>G	uc002urh.3	+	10	2547	c.2018C>G	c.(2017-2019)TCT>TGT	p.S673C	PMS1_uc010zga.1_3'UTR|PMS1_uc010zgb.1_Missense_Mutation_p.S612C|PMS1_uc002urk.3_Missense_Mutation_p.S634C|PMS1_uc002uri.3_Intron|PMS1_uc010zgc.1_Missense_Mutation_p.S497C|PMS1_uc010zgd.1_Missense_Mutation_p.S497C|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Missense_Mutation_p.S634C|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Intron|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Missense_Mutation_p.S341C	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	673					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			ACCTCATTATCTAATCAACCA	0.358			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					0	0	0	0.001855	0	13	117										G	190728630	C	G	190728630	3	3	123	1	0	0	0	0	1	0	0	0	12142	913	32	1	2052	1	PMS1	2	190728630	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	6911088	190728630	52470743	30	36802										
CCDC150	284992	broad.mit.edu	37	chr2	197521488	197521488	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgtgagtttctggtaaatcGaatgtgccgtcttgaaagcc	11	8	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:197521488G>A	uc002utp.1	+	3	443	c.308G>A	c.(307-309)CGA>CAA	p.R103Q	CCDC150_uc002uto.1_Missense_Mutation_p.R103Q|CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	103											0						CTGGTAAATCGAATGTGCCGT	0.398													0	0	0	0.008361	0	29	65										A	197521488	G	A	197521488	3	1	123	1	0	0	0	0	1	0	0	0	2785	1058	37	1	318	1	CCDC150	2	197521488	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	6792858	197521488	45677885	31	36803										
BOLL	66037	broad.mit.edu	37	chr2	198607796	198607796	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atttcttactttaattggctCaggctgcatcacaggcgcag	9	10	3	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:198607796C>G	uc002uus.2	-	10	1127	c.817G>C	c.(817-819)GAG>CAG	p.E273Q	uc002uup.2_Intron|BOLL_uc002uur.2_Missense_Mutation_p.E279Q|BOLL_uc002uut.2_Missense_Mutation_p.E285Q|BOLL_uc010zha.1_Missense_Mutation_p.E164Q|BOLL_uc002uuu.1_Missense_Mutation_p.E301Q	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2	273					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						TTAATTGGCTCAGGCTGCATC	0.358													0	0	0	0.012319	0	21	36										G	198607796	C	G	198607796	3	3	123	1	0	0	0	0	1	0	0	0	1487	835	29	1	42	1	BOLL	2	198607796	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1086308	198607796	44591577	32	36804										
PARD3B	117583	broad.mit.edu	37	chr2	205969201	205969201	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttttgaatggtgtacagacaGaactactaacttcgccaaga	8	8	0	4			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr2:205969201G>C	uc002var.1	+	5	763	c.556G>C	c.(556-558)GAA>CAA	p.E186Q	PARD3B_uc010fub.1_Missense_Mutation_p.E186Q|PARD3B_uc002vao.1_Missense_Mutation_p.E186Q|PARD3B_uc002vap.1_Missense_Mutation_p.E186Q|PARD3B_uc002vaq.1_Missense_Mutation_p.E186Q	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	186					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TGTACAGACAGAACTACTAAC	0.338													0	0	0	0.010818	0	29	128										C	205969201	G	C	205969201	3	2	123	1	0	0	0	0	1	0	0	0	11444	943	33	1	574	1	PARD3B	2	205969201	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	7361405	205969201	37230172	33	36805										
SCN10A	6336	broad.mit.edu	37	chr3	38783971	38783971	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tcccagatcagatacttctgAgacaagctggtcaagcaggg	11	10	3	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:38783971A>C	uc003ciq.2	-	13	1917	c.1917T>G	c.(1915-1917)TCT>TCG	p.S639S		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	639					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GATACTTCTGAGACAAGCTGG	0.488													0	0	0	0.004656	0	23	178										C	38783971	A	C	38783971	2	2	123	1	0	0	0	0	0	0	0	1	13912	291	11	5		5	SCN10A	3	38783971	Silent	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08		38783971	159238459	34	36806										
IMPDH2	3615	broad.mit.edu	37	chr3	49063798	49063798	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agccacttcccatgcccaccCgcagggcatccacacctgca	7	20	0	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:49063798C>T	uc003cvt.2	-	9	1057	c.965G>A	c.(964-966)CGG>CAG	p.R322Q		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	322		IMP.			GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CATGCCCACCCGCAGGGCATC	0.527													0	0	0	0.001168	0	5	47										T	49063798	C	T	49063798	3	4	123	1	0	0	0	0	1	0	0	0	7727	652	23	2	603	2	IMPDH2	3	49063798	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	10279827	49063798	148958632	35	36807										
TLR9	54106	broad.mit.edu	37	chr3	52256140	52256140	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgagggcgttggcgctaaggTtgagctctcgcagctccttg	15	10	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:52256140T>G	uc003dda.1	-	2	2826	c.2192A>C	c.(2191-2193)AAC>ACC	p.N731T	TLR9_uc003ddb.2_Missense_Mutation_p.N828T	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	731	LRR 25.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GGCGCTAAGGTTGAGCTCTCG	0.617													0	0	0	0.00245	0	14	139										G	52256140	T	G	52256140	3	3	123	1	0	0	0	0	1	0	0	0	15955	1725	60	5	910	5	TLR9	3	52256140	Missense_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	3192342	52256140	145766290	36	36808										
SFMBT1	51460	broad.mit.edu	37	chr3	52962228	52962228	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tggaggggggctgatgtgtaGgccattcttcagactccact	14	9	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:52962228G>A	uc003dgf.2	-	10	1596	c.1027C>T	c.(1027-1029)CTA>TTA	p.L343L	SFMBT1_uc010hmr.2_Silent_p.L290L|SFMBT1_uc003dgg.2_Silent_p.L343L|SFMBT1_uc003dgh.2_Silent_p.L343L	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	343	MBT 3.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CTGATGTGTAGGCCATTCTTC	0.522													0	0	0	0.010504	0	18	179										A	52962228	G	A	52962228	2	1	123	1	0	0	0	0	0	0	0	1	14157	991	35	2		2	SFMBT1	3	52962228	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	706088	52962228	145060202	37	36809										
C3orf26	84319	broad.mit.edu	37	chr3	99881159	99881159	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tatcttagaagaaaattactGatgttcttgcaaaatcagaa	6	5	3	4			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:99881159G>A	uc003dtl.2	+	4	381	c.238G>A	c.(238-240)GAT>AAT	p.D80N		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	80							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						GAAAATTACTGATGTTCTTGC	0.373													0	0	0	0.010771	0	42	53										A	99881159	G	A	99881159	3	1	123	1	0	0	0	0	1	0	0	0	2218	1290	45	1	266	1	C3orf26	3	99881159	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	46918931	99881159	98141271	38	36810										
RAB6B	51560	broad.mit.edu	37	chr3	133614283	133614283	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	caacttgaattttctcagtgGattcccaaaatctccccctg	5	13	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:133614283G>A	uc003epy.2	-	1	409	c.28C>T	c.(28-30)CCA>TCA	p.P10S	RAB6B_uc011blu.1_5'UTR	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	10					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						TTTCTCAGTGGATTCCCAAAA	0.408													0	0	0	0.004482	0	7	85										A	133614283	G	A	133614283	3	1	123	1	0	0	0	0	1	0	0	0	12952	1174	41	1	630	1	RAB6B	3	133614283	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	33733124	133614283	64408147	39	36811										
LRRC33	375387	broad.mit.edu	37	chr3	196387064	196387064	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tcgagggcctggagcgtctcCgggagctggatctgcagagg	18	10	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr3:196387064C>T	uc003fwv.2	+	3	654	c.550C>T	c.(550-552)CGG>TGG	p.R184W		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	184	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GGAGCGTCTCCGGGAGCTGGA	0.632													0	0	0	0.001984	0	6	53										T	196387064	C	T	196387064	3	4	123	1	0	0	0	0	1	0	0	0	8988	643	23	2	556	2	LRRC33	3	196387064	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	62772781	196387064	1635366	40	36812										
TMEM33	55161	broad.mit.edu	37	chr4	41941219	41941219	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctggtaatttgcaggttgcaTgaagcagcaagcttttacca	10	8	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:41941219T>C	uc003gwi.2	+	3	512	c.147T>C	c.(145-147)CAT>CAC	p.H49H	TMEM33_uc010ifw.2_Intron	NM_018126	NP_060596	P57088	TMM33_HUMAN	transmembrane protein 33	49	Helical; (Potential).					integral to membrane|melanosome	protein binding			ovary(1)	1						GCAGGTTGCATGAAGCAGCAA	0.438													0	0	0	0.008291	0	10	101										C	41941219	T	C	41941219	2	2	123	1	0	0	0	0	0	0	0	1	16153	1461	51	5		5	TMEM33	4	41941219	Silent	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08		41941219	149213057	41	36813										
CEP135	9662	broad.mit.edu	37	chr4	56818365	56818365	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gatcagctgggataccgccaGactctgacagtggagtgttt	13	9	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:56818365G>C	uc003hbi.2	+	2	303	c.69G>C	c.(67-69)CAG>CAC	p.Q23H	CEP135_uc003hbh.1_Missense_Mutation_p.Q23H|CEP135_uc010igz.1_5'Flank	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	23					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					GATACCGCCAGACTCTGACAG	0.373													0	0	0	0.010729	0	10	107										C	56818365	G	C	56818365	3	2	123	1	0	0	0	0	1	0	0	0	3247	933	33	1	71	1	CEP135	4	56818365	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	14877146	56818365	134335911	42	36814										
CSN3	1448	broad.mit.edu	37	chr4	71114859	71114859	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttaataatccatatgtgcctCgcacatattatgcaaaccca	4	11	0	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:71114859C>T	uc003hfe.3	+	4	290	c.232C>T	c.(232-234)CGC>TGC	p.R78C		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	78						extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						ATATGTGCCTCGCACATATTA	0.448													0	0	0	0.004482	0	9	91										T	71114859	C	T	71114859	3	4	123	1	0	0	0	0	1	0	0	0	3949	884	31	1	242	1	CSN3	4	71114859	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	14296494	71114859	120039417	43	36815										
SPATA5	166378	broad.mit.edu	37	chr4	123900543	123900543	+	Splice_Site	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agcaattgatgtcccaaatgTaagtcatttatgtcccacac	6	10	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:123900543T>G	uc003iez.3	+	10	1942	c.1869_splice	c.e10+2	p.N623_splice	SPATA5_uc003iey.2_Splice_Site_p.N622_splice	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5						cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						GTCCCAAATGTAAGTCATTTA	0.388													0	0	0	0.001368	0	13	172										G	123900543	T	G	123900543	5	3	123	1	0	0	0	0	0	0	1	0	15010	1652	57	5	1909	5	SPATA5	4	123900543	Splice_Site	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	52785684	123900543	67253733	44	36816										
PCDH10	57575	broad.mit.edu	37	chr4	134072052	134072052	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atgtgcccgctttcgaccaaCccgtctacactgtgtcccta	7	16	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:134072052C>T	uc003iha.2	+	1	1583	c.757C>T	c.(757-759)CCC>TCC	p.P253S	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.P253S	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	253	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TTTCGACCAACCCGTCTACAC	0.602													0	0	0	0.001984	0	7	97										T	134072052	C	T	134072052	3	4	123	1	0	0	0	0	1	0	0	0	11507	507	18	2	759	2	PCDH10	4	134072052	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	10171509	134072052	57082224	45	36817										
DCHS2	54798	broad.mit.edu	37	chr4	155254442	155254442	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggaacgctgggtggttgtcaTtgacatccatgactgttatg	13	7	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:155254442T>G	uc003inw.2	-	9	1421	c.1421A>C	c.(1420-1422)AAT>ACT	p.N474T	DCHS2_uc003inx.2_Missense_Mutation_p.N973T	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	474	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GTGGTTGTCATTGACATCCAT	0.607													0	0	0	0.007413	0	19	105										G	155254442	T	G	155254442	3	3	123	1	0	0	0	0	1	0	0	0	4288	1493	52	5	7493	5	DCHS2	4	155254442	Missense_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	21182390	155254442	35899834	46	36818										
SH3RF1	57630	broad.mit.edu	37	chr4	170017810	170017810	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttcaagttctgcctcactctGaggaggataggaaaccacca	9	11	4	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:170017810G>A	uc003isa.1	-	12	2862	c.2527C>T	c.(2527-2529)CAG>TAG	p.Q843*		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	843	SH3 4.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		GCCTCACTCTGAGGAGGATAG	0.398													0	0	0	0.001855	0	14	86										A	170017810	G	A	170017810	4	1	123	1	0	0	0	0	0	1	0	0	14258	1299	45	1	143	1	SH3RF1	4	170017810	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	14763368	170017810	21136466	47	36819										
MLF1IP	79682	broad.mit.edu	37	chr4	185622015	185622015	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tcaatcatacgctgccttttCttttcgatatctgaaatcat	4	10	5	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:185622015C>G	uc003iwq.2	-	11	1015	c.945G>C	c.(943-945)AAG>AAC	p.K315N	MLF1IP_uc003iwp.2_Intron|MLF1IP_uc003iwr.1_Intron	NM_024629	NP_078905	Q71F23	CENPU_HUMAN	MLF1 interacting protein	315	Nuclear localization signal (Potential).|Potential.				CenH3-containing nucleosome assembly at centromere|interspecies interaction between organisms|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|condensed chromosome kinetochore|cytosol|nucleoplasm					0		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Hepatocellular(41;0.000519)|Colorectal(36;0.00172)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.0299)|all_hematologic(60;0.0592)|Medulloblastoma(177;0.146)		all cancers(43;7.83e-28)|Epithelial(43;2.56e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-11)|Colorectal(24;3.27e-06)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.16e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000252)|COAD - Colon adenocarcinoma(29;0.000512)|LUSC - Lung squamous cell carcinoma(40;0.01)|READ - Rectum adenocarcinoma(43;0.0419)		GCTGCCTTTTCTTTTCGATAT	0.333													0	0	0	0.00308	0	8	87										G	185622015	C	G	185622015	3	3	123	1	0	0	0	0	1	0	0	0	9615	912	32	1	323	1	MLF1IP	4	185622015	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	15604205	185622015	5532261	48	36820										
F11	2160	broad.mit.edu	37	chr4	187201424	187201424	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	acactgatttcttgggagaaGaactggatattgttgctgca	11	6	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr4:187201424G>A	uc003iza.1	+	9	1246	c.913G>A	c.(913-915)GAA>AAA	p.E305K		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	305	Apple 4.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CTTGGGAGAAGAACTGGATAT	0.493													0	0	0	0.00499	0	16	207										A	187201424	G	A	187201424	3	1	123	1	0	0	0	0	1	0	0	0	5337	943	33	1	943	1	F11	4	187201424	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1579409	187201424	3952852	49	36821										
KIAA0947	23379	broad.mit.edu	37	chr5	5457794	5457794	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cctcctcttctgtcaccagtGccctcgccccctccgatgtc	6	21	3	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:5457794G>C	uc003jdm.3	+	12	1263	c.1041G>C	c.(1039-1041)GTG>GTC	p.V347V		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	347	Pro-rich.									ovary(1)|central_nervous_system(1)	2						TGTCACCAGTGCCCTCGCCCC	0.458													0	0	0	0.00361	0	62	420										C	5457794	G	C	5457794	2	2	123	1	0	0	0	0	0	0	0	1	8202	1306	46	4		4	KIAA0947	5	5457794	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		5457794	175457466	50	36822										
SKP2	6502	broad.mit.edu	37	chr5	36163852	36163852	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgtttgtaagaggtggtatcGcctagcgtaagtatttttca	11	5	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:36163852G>A	uc003jkc.1	+	3	568	c.386G>A	c.(385-387)CGC>CAC	p.R129H	SKP2_uc011cou.1_Intron|SKP2_uc003jkd.2_Missense_Mutation_p.R129H	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	129	F-box.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGGTGGTATCGCCTAGCGTAA	0.468													0	0	0	0.008291	0	10	120										A	36163852	G	A	36163852	3	1	123	1	0	0	0	0	1	0	0	0	14362	1087	38	2	396	2	SKP2	5	36163852	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	30706058	36163852	144751408	51	36823										
C9	735	broad.mit.edu	37	chr5	39308390	39308390	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttaaattcagctccaacagaGatttcagagaaagccagaga	8	8	2	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:39308390G>C	uc003jlv.3	-	8	1271	c.1182C>G	c.(1180-1182)ATC>ATG	p.I394M		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	394	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CTCCAACAGAGATTTCAGAGA	0.368													0	0	0	0.00308	0	8	166										C	39308390	G	C	39308390	3	2	123	1	0	0	0	0	1	0	0	0	2443	932	33	1	513	1	C9	5	39308390	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	3144538	39308390	141606870	52	36824										
GPR98	84059	broad.mit.edu	37	chr5	89985813	89985813	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgtgcaactgatgaatgaaaCaacaggaggagccagactag	12	7	0	4			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:89985813C>A	uc003kju.2	+	30	6722	c.6626C>A	c.(6625-6627)ACA>AAA	p.T2209K	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2209	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGAATGAAACAACAGGAGGA	0.398													1	0	3.07112e-06	0.010729	3.23712e-06	11	9										A	89985813	C	A	89985813	3	1	123	1	0	0	0	0	1	0	0	0	6721	478	17	4	6744	4	GPR98	5	89985813	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	50677423	89985813	90929447	53	36825										
CHD1	1105	broad.mit.edu	37	chr5	98212205	98212205	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttctgagatggaatcactatCagatccagagtatctcctac	7	10	4	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:98212205C>A	uc003knf.2	-	23	3443	c.3295G>T	c.(3295-3297)GAT>TAT	p.D1099Y	CHD1_uc010jbn.2_5'Flank	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1099					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GAATCACTATCAGATCCAGAG	0.408													1	0	3.07112e-06	0.010729	3.23712e-06	9	185										A	98212205	C	A	98212205	3	1	123	1	0	0	0	0	1	0	0	0	3323	826	29	3	1889	3	CHD1	5	98212205	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	8226392	98212205	82703055	54	36826										
APC	324	broad.mit.edu	37	chr5	112179759	112179759	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agattccaaaactgacagcaCagaatccagtggaacccaaa	7	11	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:112179759C>G	uc010jby.2	+	16	8848	c.8468C>G	c.(8467-8469)ACA>AGA	p.T2823R	APC_uc011cvt.1_Missense_Mutation_p.T2805R|APC_uc003kpz.3_Missense_Mutation_p.T2823R|APC_uc003kpy.3_Missense_Mutation_p.T2823R|APC_uc010jbz.2_Missense_Mutation_p.T2540R|APC_uc010jca.2_Missense_Mutation_p.T2123R	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2823	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ACTGACAGCACAGAATCCAGT	0.438		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			0	0	0	0.006999	0	40	42										G	112179759	C	G	112179759	3	3	123	1	0	0	0	0	1	0	0	0	763	478	17	4	8526	4	APC	5	112179759	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13967554	112179759	68735501	55	36827										
PCDHA12	56137	broad.mit.edu	37	chr5	140256667	140256667	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gctgcagttccaggtgagcgCgcgcgacgccggcgtgccgc	17	15	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:140256667C>T	uc003lic.2	+	1	1737	c.1610C>T	c.(1609-1611)GCG>GTG	p.A537V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.A537V	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	537	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGTGAGCGCGCGCGACGCC	0.687													0	0	0	0.00361	0	107	89										T	140256667	C	T	140256667	3	4	123	1	0	0	0	0	1	0	0	0	11522	768	27	2	1612	2	PCDHA12	5	140256667	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	28076908	140256667	40658593	56	36828										
PCDHB9	56127	broad.mit.edu	37	chr5	140568500	140568500	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gcgtgggcgcctcagaccgcGgctccccggctttgagcagc	15	16	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:140568500G>A	uc003liw.1	+	3	1609	c.1609G>A	c.(1609-1611)GGC>AGC	p.G537S		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	537	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCAGACCGCGGCTCCCCGGC	0.667													0	0	0	0.00361	0	46	113										A	140568500	G	A	140568500	3	1	123	1	0	0	0	0	1	0	0	0	11549	1103	39	2	1610	2	PCDHB9	5	140568500	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	311833	140568500	40346760	57	36829										
PCDHGC5	56097	broad.mit.edu	37	chr5	140890659	140890659	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agcaatgccacactgaccaaCgcagctggcaagcgggatgg	13	12	0	1	rs143362044	byFrequency	TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:140890659C>T	uc003lla.1	+	4	2754	c.2754C>T	c.(2752-2754)AAC>AAT	p.N918N	PCDHGA1_uc003lji.1_Silent_p.N905N|PCDHGA2_uc003ljk.1_Silent_p.N906N|PCDHGA3_uc003ljm.1_Silent_p.N906N|PCDHGA3_uc010jfx.1_Silent_p.N666N|PCDHGB1_uc003ljo.1_Silent_p.N901N|PCDHGA4_uc003ljq.1_Silent_p.N905N|PCDHGB2_uc003ljs.1_Silent_p.N905N|PCDHGA5_uc003lju.1_Silent_p.N905N|PCDHGB3_uc003ljw.1_Silent_p.N903N|PCDHGA6_uc003ljy.1_Silent_p.N906N|PCDHGA7_uc003lka.1_Silent_p.N906N|PCDHGB4_uc003lkc.1_Silent_p.N897N|PCDHGA8_uc003lkd.1_Silent_p.N906N|PCDHGB5_uc003lkf.1_Silent_p.N897N|PCDHGA9_uc003lkh.1_Silent_p.N906N|PCDHGB6_uc003lkj.1_Silent_p.N904N|PCDHGA10_uc003lkl.1_Silent_p.N910N|PCDHGB7_uc003lkn.1_Silent_p.N903N|PCDHGA11_uc003lkp.1_Silent_p.N724N|PCDHGA11_uc003lkq.1_Silent_p.N909N|PCDHGA12_uc003lkt.1_Silent_p.N906N|PCDHGC3_uc003lkv.1_Silent_p.N908N|PCDHGC3_uc003lkw.1_Silent_p.N108N|PCDHGC4_uc003lky.1_Silent_p.N912N	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	918	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACTGACCAACGCAGCTGGCA	0.597													0	0	0	0.004482	0	8	127										T	140890659	C	T	140890659	2	4	123	1	0	0	0	0	0	0	0	1	11571	535	19	2		2	PCDHGC5	5	140890659	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	322159	140890659	40024601	58	36830										
TCERG1	10915	broad.mit.edu	37	chr5	145890061	145890061	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaagatgtagaaaaaattttAcagaatgacaaacggtatct	7	4	1	4			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:145890061A>G	uc003lob.2	+	22	3193	c.3153A>G	c.(3151-3153)TTA>TTG	p.L1051L	TCERG1_uc003loc.2_Silent_p.L1030L	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	1051	FF 6.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAAAAATTTTACAGAATGACA	0.383													0	0	0	0.009535	0	31	46										G	145890061	A	G	145890061	2	3	123	1	0	0	0	0	0	0	0	1	15682	388	14	5		5	TCERG1	5	145890061	Silent	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	4999402	145890061	35025199	59	36831										
GRIA1	2890	broad.mit.edu	37	chr5	153144142	153144142	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aggacctagcgaagcagacaGaaattgcctacgggacgctg	13	10	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr5:153144142G>C	uc003lva.3	+	12	2337	c.1972G>C	c.(1972-1974)GAA>CAA	p.E658Q	GRIA1_uc003luy.3_Missense_Mutation_p.E658Q|GRIA1_uc003luz.3_Missense_Mutation_p.E563Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.E578Q|GRIA1_uc011dcx.1_Missense_Mutation_p.E589Q|GRIA1_uc011dcy.1_Missense_Mutation_p.E668Q|GRIA1_uc011dcz.1_Missense_Mutation_p.E668Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	658	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GAAGCAGACAGAAATTGCCTA	0.507													0	0	0	0.004482	0	8	52										C	153144142	G	C	153144142	3	2	123	1	0	0	0	0	1	0	0	0	6767	943	33	1	2018	1	GRIA1	5	153144142	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	7254081	153144142	27771118	60	36832										
DSP	1832	broad.mit.edu	37	chr6	7585963	7585963	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttacaacatgtcttcggctcCggggtcccgctccggctccc	10	17	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:7585963C>A	uc003mxp.1	+	24	8747	c.8468C>A	c.(8467-8469)CCG>CAG	p.P2823Q	DSP_uc003mxq.1_Missense_Mutation_p.P2224Q	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2823	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TCTTCGGCTCCGGGGtcccgc	0.428													1	0	2.44723e-14	0.004656	2.74936e-14	27	137										A	7585963	C	A	7585963	3	1	123	1	0	0	0	0	1	0	0	0	4781	652	23	4	8562	4	DSP	6	7585963	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08		7585963	163529104	61	36833										
HIST1H1D	3007	broad.mit.edu	37	chr6	26234919	26234919	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aagctcttgaggccaagcttGatacggctgttgtttttttc	10	8	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:26234919G>C	uc003nhd.2	-	1	298	c.243C>G	c.(241-243)ATC>ATG	p.I81M		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	81	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GGCCAAGCTTGATACGGCTGT	0.542													0	0	0	0.012319	0	22	160										C	26234919	G	C	26234919	3	2	123	1	0	0	0	0	1	0	0	0	7125	1280	45	1	426	1	HIST1H1D	6	26234919	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	18648956	26234919	144880148	62	36834										
CFB	629	broad.mit.edu	37	chr6	31918657	31918657	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctttataggcccatttgtctCccctgcaccgagggaacaac	8	14	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:31918657C>G	uc003nyj.3	+	14	2069	c.1791C>G	c.(1789-1791)CTC>CTG	p.L597L	CFB_uc011dor.1_Silent_p.L1099L	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	597	Peptidase S1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CCATTTGTCTCCCCTGCACCG	0.532													0	0	0	0.008871	0	18	130										G	31918657	C	G	31918657	2	3	123	1	0	0	0	0	0	0	0	1	3278	842	30	1		1	CFB	6	31918657	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	5683738	31918657	139196410	63	36835										
CDKN1A	1026	broad.mit.edu	37	chr6	36651924	36651925	+	Frame_Shift_Del	DEL	AA	AA	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gtcagaacccatgcggcagcAaggcctgccgccgcctcttc							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			AA	-	AA	AA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:36651924_36651925delAA	uc003omm.3	+	2	168_169	c.46_47delAA	c.(46-48)AAGfs	p.K16fs	CDKN1A_uc011dtq.1_Frame_Shift_Del_p.K50fs|CDKN1A_uc003oml.2_Frame_Shift_Del_p.K16fs|CDKN1A_uc003omn.2_Frame_Shift_Del_p.K16fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	16	C4-type (Potential).				cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						ATGCGGCAGCAAGGCCTGCCGC	0.649									Multiple_Endocrine_Neoplasia_type_1									47	24	---	---								-	36651925	AA	-	36651924	7	5	123	1	0	1	0	1	0	0	0	0	3158	131	5	0	48	0	CDKN1A	6	36651924	Frame_Shift_Del	DEL	AA	TCGA-GV-A40E-01A-12D-A23M-08	4733267	36651924	134463143	64	36836										
BEND6	221336	broad.mit.edu	37	chr6	56882036	56882037	+	Frame_Shift_Ins	INS	-	-	T													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaatggcagattgcccgttgINStaacaagagcaagcctcaga							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:56882036_56882037insT	uc010kab.2	+	5	1137_1138	c.551_552insT	c.(550-552)TGTfs	p.C184fs	BEND6_uc003pdi.3_Frame_Shift_Ins_p.C86fs	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	184	BEN.										0						ATTGCCCGTTGTAACAAGAGCA	0.361																		20	30	---	---								T	56882037	-	T	56882036	7	5	123	1	0	1	1	0	0	0	0	0	1402	1377	48	0	565	0	BEND6	6	56882036	Frame_Shift_Ins	INS	-	TCGA-GV-A40E-01A-12D-A23M-08	20230112	56882036	114233031	65	36837										
PHF3	23469	broad.mit.edu	37	chr6	64422216	64422216	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	catttttaacaaatttatcaAttcagtcaaaacaagaggaa	4	6	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:64422216A>G	uc003pep.1	+	15	4758	c.4732A>G	c.(4732-4734)ATT>GTT	p.I1578V	PHF3_uc003pen.2_Missense_Mutation_p.I1490V|PHF3_uc011dxs.1_Missense_Mutation_p.I847V	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1578					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAATTTATCAATTCAGTCAAA	0.378													0	0	0	0.000602	0	5	95										G	64422216	A	G	64422216	3	3	123	1	0	0	0	0	1	0	0	0	11836	101	4	5	4790	5	PHF3	6	64422216	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	7540180	64422216	106692851	66	36838										
IRAK1BP1	134728	broad.mit.edu	37	chr6	79577433	79577433	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cctctcctcaacacaagcccAaactgctacccgcgaggtgc	7	18	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:79577433A>C	uc003pim.2	+	1	245	c.140A>C	c.(139-141)CAA>CCA	p.Q47P	IRAK1BP1_uc010kbg.1_RNA	NM_001010844	NP_001010844	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1	47	Intrinsically disordered.				I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)		ACACAAGCCCAAACTGCTACC	0.652													0	0	0	0.001368	0	12	45										C	79577433	A	C	79577433	3	2	123	1	0	0	0	0	1	0	0	0	7822	130	5	5	142	5	IRAK1BP1	6	79577433	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	15155217	79577433	91537634	67	36839										
C6orf165	154313	broad.mit.edu	37	chr6	88144700	88144700	+	Frame_Shift_Del	DEL	A	A	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	acatagttagagaaaaggccAaaaaaaatacagagttaatt							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:88144700delA	uc003plv.2	+	11	1515	c.1423delA	c.(1423-1425)AAAfs	p.K475fs	SLC35A1_uc003plx.2_5'Flank|C6orf165_uc003plw.2_Frame_Shift_Del_p.K287fs|C6orf165_uc010kbv.1_RNA|C6orf165_uc003plu.1_Frame_Shift_Del_p.K475fs	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	475										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGAAAAGGCCAAAAAAAATAC	0.269																		7	86	---	---								-	88144700	A	-	88144700	7	5	123	1	0	1	0	1	0	0	0	0	2341	131	5	0	1461	0	C6orf165	6	88144700	Frame_Shift_Del	DEL	A	TCGA-GV-A40E-01A-12D-A23M-08	8567267	88144700	82970367	68	36840										
ECHDC1	55862	broad.mit.edu	37	chr6	127611373	127611373	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gccaccccagcttggtattaTgcccatctctttgtggacga	9	13	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:127611373T>C	uc003qax.2	-	6	601	c.565A>G	c.(565-567)ATA>GTA	p.I189V	ECHDC1_uc003qaz.3_Missense_Mutation_p.I183V|ECHDC1_uc010key.2_Missense_Mutation_p.I108V|ECHDC1_uc003qay.3_3'UTR|ECHDC1_uc010kez.2_3'UTR|ECHDC1_uc010kex.2_RNA	NM_001139510	NP_001132982	Q9NTX5	ECHD1_HUMAN	enoyl Coenzyme A hydratase domain containing 1	189							catalytic activity				0				GBM - Glioblastoma multiforme(226;0.0423)|all cancers(137;0.156)		CTTGGTATTATGCCCATCTCT	0.413													0	0	0	0.006214	0	10	84										C	127611373	T	C	127611373	3	2	123	1	0	0	0	0	1	0	0	0	4893	1464	51	5	362	5	ECHDC1	6	127611373	Missense_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	39466673	127611373	43503694	69	36841										
BCLAF1	9774	broad.mit.edu	37	chr6	136600967	136600967	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tagactgtgatctagactttGaccttgaagaatgtgatcta	9	6	2	7			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:136600967G>T	uc003qgx.1	-	3	291	c.38C>A	c.(37-39)TCA>TAA	p.S13*	BCLAF1_uc003qgw.1_Nonsense_Mutation_p.S13*|BCLAF1_uc003qgy.1_Nonsense_Mutation_p.S13*|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Nonsense_Mutation_p.S13*	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	13					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCTAGACTTTGACCTTGAAGA	0.303													1	0	1.12685e-05	0.004482	1.18319e-05	9	75										T	136600967	G	T	136600967	4	4	123	1	0	0	0	0	0	1	0	0	1383	1294	45	3	2768	3	BCLAF1	6	136600967	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	8989594	136600967	34514100	70	36842										
PHACTR2	9749	broad.mit.edu	37	chr6	144081695	144081696	+	Frame_Shift_Ins	INS	-	-	A													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gtgatgaagtgcctcccattINSaaaaaaaataccaaggctcc							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:144081695_144081696insA	uc003qjq.3	+	5	709_710	c.579_580insA	c.(577-582)ATTAAAfs	p.I193fs	PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Frame_Shift_Ins_p.I204fs|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	193_194							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TGCCTCCCATTAAAAAAAATAC	0.569																		8	252	---	---								A	144081696	-	A	144081695	7	5	123	1	0	1	1	0	0	0	0	0	11810	1742	61	0	647	0	PHACTR2	6	144081695	Frame_Shift_Ins	INS	-	TCGA-GV-A40E-01A-12D-A23M-08	7480728	144081695	27033372	71	36843										
SASH1	23328	broad.mit.edu	37	chr6	148864865	148864865	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gccaagtcatccaccgagccCagcttgaagtcttttagcag	9	13	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:148864865C>G	uc003qme.1	+	18	2734	c.2259C>G	c.(2257-2259)CCC>CCG	p.P753P	SASH1_uc011eeb.1_Silent_p.P514P|SASH1_uc003qmf.1_Silent_p.P163P	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	753							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CCACCGAGCCCAGCTTGAAGT	0.463													0	0	0	0.00278	0	21	93										G	148864865	C	G	148864865	2	3	123	1	0	0	0	0	0	0	0	1	13848	581	21	4		4	SASH1	6	148864865	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	4783170	148864865	22250202	72	36844										
C6orf72	116254	broad.mit.edu	37	chr6	149901812	149901812	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atgaagatgttttacctggcAagttacctgaaactcctctc	7	10	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:149901812A>C	uc003qmq.1	+	6	697	c.670A>C	c.(670-672)AAG>CAG	p.K224Q	C6orf72_uc010kie.1_Missense_Mutation_p.K104Q	NM_138785	NP_620140	Q9NU53	CF072_HUMAN	hypothetical protein LOC116254 precursor	224	Extracellular (Potential).					integral to membrane					0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.66e-12)|GBM - Glioblastoma multiforme(68;0.171)		TTTACCTGGCAAGTTACCTGA	0.398													0	0	0	0.001168	0	6	107										C	149901812	A	C	149901812	3	2	123	1	0	0	0	0	1	0	0	0	2371	131	5	5	692	5	C6orf72	6	149901812	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	1036947	149901812	21213255	73	36845										
AKAP12	9590	broad.mit.edu	37	chr6	151671634	151671634	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctcttctgatgaggaaggggGaccaaaagcaatgggaggag	16	6	2	2	rs151321698	byFrequency	TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:151671634G>A	uc011eep.1	+	4	2348	c.2108G>A	c.(2107-2109)GGA>GAA	p.G703E	AKAP12_uc003qoe.2_Missense_Mutation_p.G703E|AKAP12_uc003qof.2_Missense_Mutation_p.G605E|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.G598E	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	703					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GAGGAAGGGGGACCAAAAGCA	0.502													0	0	0	0.00499	0	17	150										A	151671634	G	A	151671634	3	1	123	1	0	0	0	0	1	0	0	0	448	1174	41	1	2147	1	AKAP12	6	151671634	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1769822	151671634	19443433	74	36846										
SYNE1	23345	broad.mit.edu	37	chr6	152621819	152621819	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tagccacaggtgaaggggagCgacaggcaggtggagaggaa	19	6	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr6:152621819C>G	uc010kiw.2	-	93	18241	c.17639G>C	c.(17638-17640)CGC>CCC	p.R5880P	SYNE1_uc010kiv.2_Missense_Mutation_p.R404P|SYNE1_uc003qos.3_Missense_Mutation_p.R404P|SYNE1_uc003qot.3_Missense_Mutation_p.R5809P|SYNE1_uc003qou.3_Missense_Mutation_p.R5880P|SYNE1_uc010kiy.1_Intron	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5880	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGAAGGGGAGCGACAGGCAGG	0.537										HNSCC(10;0.0054)			0	0	0	0.004482	0	6	74										G	152621819	C	G	152621819	3	3	123	1	0	0	0	0	1	0	0	0	15442	768	27	4	9043	4	SYNE1	6	152621819	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	950185	152621819	18493248	75	36847										
CARD11	84433	broad.mit.edu	37	chr7	2954983	2954983	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttgctgttcatccgcttataCttgttctcggacctgctgac	8	12	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:2954983C>G	uc003smv.2	-	21	3131	c.2727G>C	c.(2725-2727)AAG>AAC	p.K909N		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	909					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCCGCTTATACTTGTTCTCGG	0.602			Mis		DLBCL								0	0	0	0.008291	0	9	86										G	2954983	C	G	2954983	3	3	123	1	0	0	0	0	1	0	0	0	2645	564	20	4	757	4	CARD11	7	2954983	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08		2954983	156183680	76	36848										
CARD11	84433	broad.mit.edu	37	chr7	2956960	2956960	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaaaggaagcttgctcgcgaGagacgggggctgacccgggg	18	9	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:2956960G>C	uc003smv.2	-	20	3071	c.2667C>G	c.(2665-2667)CTC>CTG	p.L889L		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	889					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGCTCGCGAGAGACGGGGGC	0.557			Mis		DLBCL								0	0	0	0.009096	0	4	40										C	2956960	G	C	2956960	2	2	123	1	0	0	0	0	0	0	0	1	2645	929	33	1		1	CARD11	7	2956960	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1977	2956960	156181703	77	36849										
AGR3	155465	broad.mit.edu	37	chr7	16913456	16913456	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agtttgtacccaagtgatgtCatctccccatcctgaaatag	7	11	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:16913456C>T	uc003sts.2	-	3	194	c.121G>A	c.(121-123)GAC>AAC	p.D41N		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	41						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		CAAGTGATGTCATCTCCCCAT	0.348													0	0	0	0.004482	0	9	126										T	16913456	C	T	16913456	3	4	123	1	0	0	0	0	1	0	0	0	396	826	29	1	403	1	AGR3	7	16913456	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13956496	16913456	142225207	78	36850										
OGDH	4967	broad.mit.edu	37	chr7	44746824	44746824	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ccatgggaactctcttgtagGaacccacttccagcgggtga	11	12	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:44746824G>A	uc003tln.2	+	21	2742	c.2633G>A	c.(2632-2634)GGA>GAA	p.G878E	OGDH_uc011kbx.1_Missense_Mutation_p.G874E|OGDH_uc011kby.1_Missense_Mutation_p.G728E|OGDH_uc003tlp.2_Missense_Mutation_p.G889E|OGDH_uc011kbz.1_Missense_Mutation_p.G673E	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	878					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TCTCTTGTAGGAACCCACTTC	0.562													0	0	0	0.001984	0	6	102										A	44746824	G	A	44746824	3	1	123	1	0	0	0	0	1	0	0	0	10839	1188	41	1	2884	1	OGDH	7	44746824	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	27833368	44746824	114391839	79	36851										
TPST1	8460	broad.mit.edu	37	chr7	65817531	65817531	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aactacctgactttcttaaaGaaaaaccacaggtactgtgt	6	9	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:65817531G>C	uc003tuw.2	+	4	1436	c.1084G>C	c.(1084-1086)GAA>CAA	p.E362Q	TPST1_uc010kzy.2_RNA|TPST1_uc010kzz.2_Missense_Mutation_p.E362Q|TPST1_uc010laa.2_Intron	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	362	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						CTTTCTTAAAGAAAAACCACA	0.383													0	0	0	0.003954	0	22	187										C	65817531	G	C	65817531	3	2	123	1	0	0	0	0	1	0	0	0	16424	943	33	1	1094	1	TPST1	7	65817531	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	21070707	65817531	93321132	80	36852										
PCLO	27445	broad.mit.edu	37	chr7	82585934	82585934	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gttttctcttggtctttaggCtgttcaggagaaacttcatg	10	7	4	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:82585934C>T	uc003uhx.2	-	5	4624	c.4335G>A	c.(4333-4335)CAG>CAA	p.Q1445Q	PCLO_uc003uhv.2_Silent_p.Q1445Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1376					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGTCTTTAGGCTGTTCAGGAG	0.373													0	0	0	0.010818	0	33	57										T	82585934	C	T	82585934	2	4	123	1	0	0	0	0	0	0	0	1	11583	796	28	2		2	PCLO	7	82585934	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	16768403	82585934	76552729	81	36853										
SMURF1	57154	broad.mit.edu	37	chr7	98638102	98638103	+	Frame_Shift_Ins	INS	-	-	C													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgtagaagggcactgtgaagINScccccgttgatgtagtgtcc							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:98638102_98638103insC	uc003upu.1	-	14	1846_1847	c.1526_1527insG	c.(1525-1527)GGCfs	p.G509fs	SMURF1_uc003upv.1_Frame_Shift_Ins_p.G483fs|SMURF1_uc003upt.2_Frame_Shift_Ins_p.G483fs	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	509	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GCACTGTGAAGCCCCCGTTGAT	0.559											OREG0018189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						12	177	---	---								C	98638103	-	C	98638102	7	5	123	1	0	1	1	0	0	0	0	0	14819	958	34	0	770	0	SMURF1	7	98638102	Frame_Shift_Ins	INS	-	TCGA-GV-A40E-01A-12D-A23M-08	16052168	98638102	60500561	82	36854										
FBXL13	222235	broad.mit.edu	37	chr7	102669092	102669092	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	catataagagtgccagtgatGaaatacagatttttgaagtc	9	5	0	5			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:102669092G>A	uc003vaq.2	-	4	599	c.172C>T	c.(172-174)CAT>TAT	p.H58Y	FBXL13_uc010lir.1_Missense_Mutation_p.H58Y|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.H58Y|FBXL13_uc003vav.2_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	58											0						TGCCAGTGATGAAATACAGAT	0.318													0	0	0	0.00308	0	8	101										A	102669092	G	A	102669092	3	1	123	1	0	0	0	0	1	0	0	0	5709	1290	45	1	2103	1	FBXL13	7	102669092	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	4030990	102669092	56469571	83	36855										
OR6B1	135946	broad.mit.edu	37	chr7	143701410	143701410	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgtacttcttcattgctctCatgtgcacagaatgtgtgct	8	10	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:143701410C>G	uc003wdt.1	+	1	321	c.321C>G	c.(319-321)CTC>CTG	p.L107L		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TCATTGCTCTCATGTGCACAG	0.483													0	0	0	0.004007	0	16	262										G	143701410	C	G	143701410	2	3	123	1	0	0	0	0	0	0	0	1	11187	813	29	1		1	OR6B1	7	143701410	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	41032318	143701410	15437253	84	36856										
GBX1	2636	broad.mit.edu	37	chr7	150845868	150845868	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atcttgacctgcacctcactGagcttgagggcgtgggcgat	13	11	2	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr7:150845868G>A	uc011kvg.1	-	2	1132	c.900C>T	c.(898-900)CTC>CTT	p.L300L		NM_001098834	NP_001092304	Q14549	GBX1_HUMAN	gastrulation brain homeo box 1	300	Homeobox.					nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCACCTCACTGAGCTTGAGGG	0.522													0	0	0	0.006214	0	9	160										A	150845868	G	A	150845868	2	1	123	1	0	0	0	0	0	0	0	1	6280	1277	45	1		1	GBX1	7	150845868	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	7144458	150845868	8292795	85	36857										
CDCA2	157313	broad.mit.edu	37	chr8	25365244	25365244	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gattgaacataatggagaaaGaaagcagtaattgacatttc	9	4	0	4			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr8:25365244G>C	uc003xep.1	+	15	3541	c.3062G>C	c.(3061-3063)AGA>ACA	p.R1021T	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.R1006T|CDCA2_uc003xer.1_Missense_Mutation_p.R684T	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	1021					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AATGGAGAAAGAAAGCAGTAA	0.453													0	0	0	0.001168	0	6	82										C	25365244	G	C	25365244	3	2	123	1	0	0	0	0	1	0	0	0	3086	942	33	1	3116	1	CDCA2	8	25365244	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		25365244	120998778	86	36858										
TSPYL5	85453	broad.mit.edu	37	chr8	98288924	98288924	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tctacacgagccccttcactCaaaaggtagaactgcaaggg	9	12	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr8:98288924C>T	uc003yhy.2	-	1	1253	c.1149G>A	c.(1147-1149)TTG>TTA	p.L383L		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	383					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)					CCCCTTCACTCAAAAGGTAGA	0.483													0	0	0	0.00361	0	42	321										T	98288924	C	T	98288924	2	4	123	1	0	0	0	0	0	0	0	1	16659	825	29	1		1	TSPYL5	8	98288924	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	72923680	98288924	48075098	87	36859										
OXR1	55074	broad.mit.edu	37	chr8	107719297	107719297	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	actatgcaacaaactaaacaGcaaagggaaaatattcaaca	5	8	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr8:107719297G>C	uc011lht.1	+	8	1650	c.1551G>C	c.(1549-1551)CAG>CAC	p.Q517H	OXR1_uc003ymf.2_Missense_Mutation_p.Q516H|OXR1_uc011lhu.1_Missense_Mutation_p.Q509H|OXR1_uc010mcg.2_Intron|OXR1_uc010mch.2_Missense_Mutation_p.Q214H|OXR1_uc003ymg.1_Missense_Mutation_p.Q449H|OXR1_uc003ymi.1_Missense_Mutation_p.Q428H	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	517					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			AAACTAAACAGCAAAGGGAAA	0.368													0	0	0	0.010729	0	12	151										C	107719297	G	C	107719297	3	2	123	1	0	0	0	0	1	0	0	0	11334	962	34	4	1781	4	OXR1	8	107719297	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	9430373	107719297	38644725	88	36860										
ABRA	137735	broad.mit.edu	37	chr8	107773566	107773566	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggcggccatagccctcatctCctttgtgtaggcgggtggac	14	12	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr8:107773566C>T	uc003ymm.3	-	2	899	c.845G>A	c.(844-846)GGA>GAA	p.G282E		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	282	Interaction with actin (By similarity).				positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			GCCCTCATCTCCTTTGTGTAG	0.517													0	0	0	0.00361	0	75	100										T	107773566	C	T	107773566	3	4	123	1	0	0	0	0	1	0	0	0	100	855	30	1	304	1	ABRA	8	107773566	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	54269	107773566	38590456	89	36861										
PHF20L1	51105	broad.mit.edu	37	chr8	133827086	133827086	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cagaattaatacaagtcgagGatttgacgcttgtatctcag	9	7	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr8:133827086G>C	uc003ytt.2	+	10	1460	c.1135G>C	c.(1135-1137)GAT>CAT	p.D379H	PHF20L1_uc003yts.2_Missense_Mutation_p.D379H|PHF20L1_uc011lja.1_Missense_Mutation_p.D353H|PHF20L1_uc003ytu.1_RNA	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	379							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			ACAAGTCGAGGATTTGACGCT	0.348													0	0	0	0.005443	0	21	167										C	133827086	G	C	133827086	3	2	123	1	0	0	0	0	1	0	0	0	11832	1174	41	1	1175	1	PHF20L1	8	133827086	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	26053520	133827086	12536936	90	36862										
HAUS6	54801	broad.mit.edu	37	chr9	19093277	19093277	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaatagtgaaccaacaacttGaggaaagctacttccacatt	6	9	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:19093277G>C	uc003znk.2	-	4	581	c.328C>G	c.(328-330)CAA>GAA	p.Q110E	HAUS6_uc003znl.1_5'UTR	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	110					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						CCAACAACTTGAGGAAAGCTA	0.313													0	0	0	0.008291	0	11	74										C	19093277	G	C	19093277	3	2	123	1	0	0	0	0	1	0	0	0	6970	1299	45	1	2595	1	HAUS6	9	19093277	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		19093277	122120154	91	36863										
CDKN2A	1029	broad.mit.edu	37	chr9	21971111	21971111	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gccctcccgggcagcgtcgtGcacgggtcgggtgagagtgg	19	12	0	1	rs121913385		TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:21971111G>A	uc003zpk.2	-	2	459	c.247C>T	c.(247-249)CAC>TAC	p.H83Y	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.A138V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	83	ANK 3.		H -> N (in a lung tumor).|H -> Y (in a pancreas and a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.H83Y(28)|p.?(13)|p.H83fs*2(2)|p.H83P(2)|p.H83N(1)|p.V82fs*62(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.A138V(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.H83R(1)|p.H83Q(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGCGTCGTGCACGGGTCGG	0.741	H83Y(CALU3_LUNG)|H83Y(JHH2_LIVER)|H83Y(HS944T_SKIN)|H83Y(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|H83Y(OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.00245	0	11	16										A	21971111	G	A	21971111	3	1	123	1	0	0	0	0	1	0	0	0	3161	1319	46	2	231	2	CDKN2A	9	21971111	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	2877834	21971111	119242320	92	36864										
KIAA1045	23349	broad.mit.edu	37	chr9	34977116	34977116	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttctgacagtgaaggagcggGagcgagcccgagccgccttc	15	12	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:34977116G>T	uc003zvq.2	+	6	1064	c.886G>T	c.(886-888)GAG>TAG	p.E296*	KIAA1045_uc003zvr.2_Nonsense_Mutation_p.E296*	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	296							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			GAAGGAGCGGGAGCGAGCCCG	0.572													1	0	1.88708e-17	0.008361	2.13765e-17	27	76										T	34977116	G	T	34977116	4	4	123	1	0	0	0	0	0	1	0	0	8207	1175	41	3	904	3	KIAA1045	9	34977116	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	13006005	34977116	106236315	93	36865										
WNK2	65268	broad.mit.edu	37	chr9	96079823	96079823	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgaccgcacctcgagcaggaGtggggatgccacgtctgccc	14	14	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:96079823G>A	uc004ati.1	+	29	6649	c.6649G>A	c.(6649-6651)GTG>ATG	p.V2217M	WNK2_uc011lud.1_Missense_Mutation_p.V2180M|WNK2_uc004atj.2_Missense_Mutation_p.V2180M|WNK2_uc004atk.2_Missense_Mutation_p.V1705M	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	2217					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TCGAGCAGGAGTGGGGATGCC	0.657													0	0	0	0.00623	0	33	32										A	96079823	G	A	96079823	3	1	123	1	0	0	0	0	1	0	0	0	17375	1029	36	2	6648	2	WNK2	9	96079823	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	61102707	96079823	45133608	94	36866										
MUSK	4593	broad.mit.edu	37	chr9	113444998	113444998	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaacagtggatgccttagttGaagaagtggctactttcatg	11	6	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:113444998G>C	uc004bey.2	+	2	222	c.124G>C	c.(124-126)GAA>CAA	p.E42Q	MUSK_uc004bex.2_Missense_Mutation_p.E42Q	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	42	Ig-like 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TGCCTTAGTTGAAGAAGTGGC	0.393													0	0	0	0.006122	0	18	200										C	113444998	G	C	113444998	3	2	123	1	0	0	0	0	1	0	0	0	9989	1291	45	1	130	1	MUSK	9	113444998	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	17365175	113444998	27768433	95	36867										
LHX2	9355	broad.mit.edu	37	chr9	126794886	126794886	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gacagacttgactagccccaCcctgccaactgtgacgtccg	9	16	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:126794886C>T	uc004boe.1	+	5	1860	c.1121C>T	c.(1120-1122)ACC>ATC	p.T374I	LHX2_uc010mwi.1_Missense_Mutation_p.T382I	NM_004789	NP_004780	P50458	LHX2_HUMAN	LIM homeobox protein 2	374						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACTAGCCCCACCCTGCCAACT	0.617													0	0	0	0.004482	0	8	68										T	126794886	C	T	126794886	3	4	123	1	0	0	0	0	1	0	0	0	8771	507	18	2	1139	2	LHX2	9	126794886	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13349888	126794886	14418545	96	36868										
DNM1	1759	broad.mit.edu	37	chr9	131010868	131010868	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gttctccatggcaggccagcGagaccgaggagaatggctcc	14	12	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:131010868G>T	uc011mau.1	+	19	1999	c.1912G>T	c.(1912-1914)GAG>TAG	p.E638*	DNM1_uc011mat.1_Nonsense_Mutation_p.E638*|DNM1_uc004bub.1_Nonsense_Mutation_p.E11*|DNM1_uc004buc.1_Nonsense_Mutation_p.E105*|DNM1_uc004bud.3_RNA	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	638					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						GCAGGCCAGCGAGACCGAGGA	0.597													1	0	2.61681e-11	0.00245	2.85756e-11	15	109										T	131010868	G	T	131010868	4	4	123	1	0	0	0	0	0	1	0	0	4670	1059	37	3	1981	3	DNM1	9	131010868	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	4215982	131010868	10202563	97	36869										
MAMDC4	158056	broad.mit.edu	37	chr9	139750491	139750491	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gcacttcctgtctctgcagcGggcctgggggcagctaggcg	16	13	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr9:139750491G>A	uc004cjs.2	+	14	1660	c.1610G>A	c.(1609-1611)CGG>CAG	p.R537Q	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TCTCTGCAGCGGGCCTGGGGG	0.632													0	0	0	0.008871	0	18	110										A	139750491	G	A	139750491	3	1	123	1	0	0	0	0	1	0	0	0	9204	1116	39	2	1664	2	MAMDC4	9	139750491	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	8739623	139750491	1462940	98	36870										
TUBAL3	79861	broad.mit.edu	37	chr10	5436157	5436157	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gcattcaacaccgagtttacGatggcatatatcatagacgg	9	9	2	1	rs149499697	byFrequency	TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:5436157G>A	uc001ihy.2	-	4	704	c.664C>T	c.(664-666)CGT>TGT	p.R222C	TUBAL3_uc001ihz.2_Missense_Mutation_p.R182C	NM_024803	NP_079079	A6NHL2	TBAL3_HUMAN	tubulin, alpha-like 3	222					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1						CCGAGTTTACGATGGCATATA	0.522													0	0	0	0.001168	0	6	126										A	5436157	G	A	5436157	3	1	123	1	0	0	0	0	1	0	0	0	16748	1058	37	1	680	1	TUBAL3	10	5436157	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		5436157	130098590	99	36871										
STAM	8027	broad.mit.edu	37	chr10	17750829	17750829	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tggttgcagggaacgcgcagAtgagccacctccagagctac	13	12	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:17750829A>T	uc001ipj.1	+	13	1480	c.1264A>T	c.(1264-1266)ATG>TTG	p.M422L	STAM_uc009xjw.1_Missense_Mutation_p.M80L	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	422					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						GAACGCGCAGATGAGCCACCT	0.527													0	0	0	0.007835	0	41	103										T	17750829	A	T	17750829	3	4	123	1	0	0	0	0	1	0	0	0	15247	333	12	5	1314	5	STAM	10	17750829	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	12314672	17750829	117783918	100	36872										
CUL2	8453	broad.mit.edu	37	chr10	35351949	35351949	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tttctgtataaagtctttctCcaaggggttcaggataggcc	10	8	4	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:35351949C>G	uc001ixv.2	-	3	371	c.161G>C	c.(160-162)GGA>GCA	p.G54A	CUL2_uc009xma.2_5'UTR|CUL2_uc010qer.1_Missense_Mutation_p.G73A|CUL2_uc001ixw.2_Missense_Mutation_p.G54A|CUL2_uc010qes.1_Missense_Mutation_p.G54A	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	54					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						AAGTCTTTCTCCAAGGGGTTC	0.299													0	0	0	0.003163	0	14	123										G	35351949	C	G	35351949	3	3	123	1	0	0	0	0	1	0	0	0	4055	855	30	1	2152	1	CUL2	10	35351949	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	17601120	35351949	100182798	101	36873										
BMS1	9790	broad.mit.edu	37	chr10	43281092	43281092	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	acccggcagaagttgactgaGatcagaggccctgtgacgat	13	10	1	5			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:43281092G>C	uc001jaj.2	+	3	697	c.339G>C	c.(337-339)GAG>GAC	p.E113D		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	113					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						AGTTGACTGAGATCAGAGGCC	0.507													0	0	0	0.00632	0	26	259										C	43281092	G	C	43281092	3	2	123	1	0	0	0	0	1	0	0	0	1472	933	33	1	345	1	BMS1	10	43281092	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	7929143	43281092	92253655	102	36874										
PRF1	5551	broad.mit.edu	37	chr10	72358024	72358024	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atcgtccctgccagagtcctGatcccagacctgcaacctca	7	17	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:72358024G>C	uc009xqg.2	-	3	1614	c.1453C>G	c.(1453-1455)CAG>GAG	p.Q485E	PRF1_uc001jrf.3_Missense_Mutation_p.Q485E	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	485	C2.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CCAGAGTCCTGATCCCAGACC	0.582			M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.00245	0	15	121										C	72358024	G	C	72358024	3	2	123	1	0	0	0	0	1	0	0	0	12478	1299	45	1	218	1	PRF1	10	72358024	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	29076932	72358024	63176723	103	36875										
PTEN	5728	broad.mit.edu	37	chr10	89717615	89717615	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tatttaaccatgcagatcctCagtttgtggtctgccagcta	8	10	2	1	rs121909227		TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:89717615C>T	uc001kfb.2	+	8	1671	c.640C>T	c.(640-642)CAG>TAG	p.Q214*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	214	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.Q214*(8)|p.R55fs*1(4)|p.N212fs*1(2)|p.Y27fs*1(2)|p.G165_*404del(1)|p.?(1)|p.G165_K342del(1)|p.Q214fs*22(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TGCAGATCCTCAGTTTGTGGT	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			0	0	0	0.00361	0	72	55										T	89717615	C	T	89717615	4	4	123	1	0	0	0	0	0	1	0	0	12738	827	29	1	666	1	PTEN	10	89717615	Nonsense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	17359591	89717615	45817132	104	36876										
ADRA2A	150	broad.mit.edu	37	chr10	112838906	112838906	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cgcgggcggcagaaccgcgaGaagcgcttcacgttcgtgct	15	13	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr10:112838906G>A	uc001kzo.2	+	1	2117	c.1152G>A	c.(1150-1152)GAG>GAA	p.E384E		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	369	Cytoplasmic (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	AGAACCGCGAGAAGCGCTTCA	0.667													0	0	0	0.010729	0	11	66										A	112838906	G	A	112838906	2	1	123	1	0	0	0	0	0	0	0	1	337	933	33	1		1	ADRA2A	10	112838906	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	23121291	112838906	22695841	105	36877										
IGSF22	283284	broad.mit.edu	37	chr11	18737135	18737135	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gctgtacttagtgccatgcaTcagcagctgcccatccttct	8	14	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:18737135T>A	uc009yht.2	-	11	1565	c.1375A>T	c.(1375-1377)ATG>TTG	p.M459L	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	459	Ig-like 3.									ovary(4)|large_intestine(2)|kidney(1)	7						GTGCCATGCATCAGCAGCTGC	0.537													0	0	0	0.010729	0	12	78										A	18737135	T	A	18737135	3	1	123	1	0	0	0	0	1	0	0	0	7600	1435	50	5	2657	5	IGSF22	11	18737135	Missense_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08		18737135	116269381	106	36878										
MPPED2	744	broad.mit.edu	37	chr11	30439147	30439147	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agcagagactgacctctgggTaggttaaagccccatccatt	10	11	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:30439147T>C	uc001msr.2	-	4	690	c.570A>G	c.(568-570)CTA>CTG	p.L190L	MPPED2_uc001msq.3_Silent_p.L190L|MPPED2_uc009yji.2_Silent_p.L64L	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	190					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						GACCTCTGGGTAGGTTAAAGC	0.517													0	0	0	0.004672	0	3	37										C	30439147	T	C	30439147	2	2	123	1	0	0	0	0	0	0	0	1	9742	1625	57	5		5	MPPED2	11	30439147	Silent	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	11702012	30439147	104567369	107	36879										
OR5L2	26338	broad.mit.edu	37	chr11	55595183	55595183	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgattcactcgtccttagcTcttaggatcctcttctatag	6	12	4	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:55595183T>C	uc001nhy.1	+	1	489	c.489T>C	c.(487-489)GCT>GCC	p.A163A		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CGTCCTTAGCTCTTAGGATCC	0.473										HNSCC(27;0.073)			0	0	0	0.002299	0	23	475										C	55595183	T	C	55595183	2	2	123	1	0	0	0	0	0	0	0	1	11171	1538	54	5		5	OR5L2	11	55595183	Silent	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	25156036	55595183	79411333	108	36880										
INTS5	80789	broad.mit.edu	37	chr11	62415419	62415419	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	actgagagagtctcattgtcCccatctacttgcccaccaaa	6	14	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:62415419C>T	uc001nud.2	-	2	2186	c.2133G>A	c.(2131-2133)GGG>GGA	p.G711G	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	711					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						TCTCATTGTCCCCATCTACTT	0.557													0	0	0	0.001984	0	7	80										T	62415419	C	T	62415419	2	4	123	1	0	0	0	0	0	0	0	1	7781	610	22	2		2	INTS5	11	62415419	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	6820236	62415419	72591097	109	36881										
NUDT22	84304	broad.mit.edu	37	chr11	63996776	63996776	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgttgggcatcgcccgaaatGagaccagtgctggccgagcc	14	12	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:63996776G>A	uc001nyp.3	+	4	817	c.637G>A	c.(637-639)GAG>AAG	p.E213K	NUDT22_uc009ype.2_Missense_Mutation_p.E213K|NUDT22_uc001nyq.3_Missense_Mutation_p.E180K|NUDT22_uc010rng.1_RNA|uc001nyr.1_3'UTR|DNAJC4_uc001nys.2_5'Flank|DNAJC4_uc001nyt.2_5'Flank|DNAJC4_uc001nyu.2_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	213	Nudix hydrolase.						hydrolase activity				0						CGCCCGAAATGAGACCAGTGC	0.632													0	0	0	0.004672	0	3	11										A	63996776	G	A	63996776	3	1	123	1	0	0	0	0	1	0	0	0	10739	1291	45	1	647	1	NUDT22	11	63996776	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1581357	63996776	71009740	110	36882										
SPDYC	387778	broad.mit.edu	37	chr11	64939959	64939959	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggccccaaatgtgagattttTccatgggccctgggaaaaga	12	9	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:64939959T>C	uc010rnz.1	+	5	399	c.399T>C	c.(397-399)TTT>TTC	p.F133F		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	133	Speedy/Ringo box; Required for CDK- binding (By similarity).				cell cycle	nucleus	protein kinase binding				0						GTGAGATTTTTCCATGGGCCC	0.557													0	0	0	0.00245	0	13	143										C	64939959	T	C	64939959	2	2	123	1	0	0	0	0	0	0	0	1	15027	1780	62	5		5	SPDYC	11	64939959	Silent	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	943183	64939959	70066557	111	36883										
LTBP3	4054	broad.mit.edu	37	chr11	65315511	65315511	+	Missense_Mutation	SNP	C	C	A													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctggttcagtcggcactcatCagtctctgcgggcatggcca							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:65315511C>A	uc001oej.2	-	12	1995	c.1726G>T	c.(1726-1728)GAT>TAT	p.D576Y	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Missense_Mutation_p.D6Y|LTBP3_uc010roi.1_Missense_Mutation_p.D459Y|LTBP3_uc001oei.2_Missense_Mutation_p.D576Y|LTBP3_uc010roj.1_Missense_Mutation_p.D277Y|LTBP3_uc010rok.1_Missense_Mutation_p.D487Y	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	576	EGF-like 3.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CGGCACTCATCAGTCTCTGCG	0.637													1	0	3.59834e-05	0.001168	3.73515e-05	5	80										A	65315511	C	A	65315511	3	1	123	1	0	0	0	0	1	0	0	0	9075	826	29	3	2253	3	LTBP3	11	65315511	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	375552	65315511	69691005	112	36884	192	2								
LTBP3	4054	broad.mit.edu	37	chr11	65315517	65315517	+	Splice_Site	SNP	C	C	T													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cagtcggcactcatcagtctCtgcgggcatggccaggtcaa							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:65315517C>T	uc001oej.2	-	12	1990	c.1721_splice	c.e12-1	p.E574_splice	LTBP3_uc001oeg.2_5'Flank|LTBP3_uc001oeh.2_Missense_Mutation_p.E4K|LTBP3_uc010roi.1_Splice_Site_p.E457_splice|LTBP3_uc001oei.2_Splice_Site_p.E574_splice|LTBP3_uc010roj.1_Splice_Site_p.E275_splice|LTBP3_uc010rok.1_Splice_Site_p.E485_splice	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding							extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						TCATCAGTCTCTGCGGGCATG	0.637													0	0	0	0.001168	0	5	80										T	65315517	C	T	65315517	5	4	123	1	0	0	0	0	0	0	1	0	9075	927	32	1	2259	1	LTBP3	11	65315517	Splice_Site	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	6	65315517	69690999	113	36885	192	2								
SHANK2	22941	broad.mit.edu	37	chr11	70319061	70319061	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agatcgatgaggtcctccttCtgcaggtttggtaagtgact	12	8	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:70319061C>G	uc001oqc.2	-	22	5541	c.5463G>C	c.(5461-5463)CAG>CAC	p.Q1821H	SHANK2_uc010rqn.1_Missense_Mutation_p.Q1233H|SHANK2_uc001opz.2_Missense_Mutation_p.Q1226H|uc009ysn.1_5'UTR|SHANK2_uc001opy.2_Missense_Mutation_p.Q157H	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1442	SAM.				intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGTCCTCCTTCTGCAGGTTTG	0.493													0	0	0	0.00278	0	21	448										G	70319061	C	G	70319061	3	3	123	1	0	0	0	0	1	0	0	0	14265	912	32	1	90	1	SHANK2	11	70319061	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	5003544	70319061	64687455	114	36886										
RNF169	254225	broad.mit.edu	37	chr11	74500681	74500681	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tttctttcagactttatattCagagcaccaatcaaattaag	4	8	4	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:74500681C>G	uc001ovl.3	+	2	526	c.513C>G	c.(511-513)TTC>TTG	p.F171L		NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	171							zinc ion binding			ovary(1)	1						ACTTTATATTCAGAGCACCAA	0.343													0	0	0	0.004007	0	14	228										G	74500681	C	G	74500681	3	3	123	1	0	0	0	0	1	0	0	0	13460	825	29	1	519	1	RNF169	11	74500681	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	4181620	74500681	60505835	115	36887										
MTMR2	8898	broad.mit.edu	37	chr11	95568599	95568599	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tagcaagaagttctttgtatCtgttgtgaataggttcctgc	10	6	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:95568599C>G	uc001pfu.2	-	15	2040	c.1787G>C	c.(1786-1788)AGA>ACA	p.R596T	MTMR2_uc001pfv.2_Missense_Mutation_p.R524T|MTMR2_uc001pfs.2_Missense_Mutation_p.R524T|MTMR2_uc001pft.2_Missense_Mutation_p.R524T	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	596						nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTCTTTGTATCTGTTGTGAAT	0.408													0	0	0	0.006214	0	9	128										G	95568599	C	G	95568599	3	3	123	1	0	0	0	0	1	0	0	0	9944	913	32	1	148	1	MTMR2	11	95568599	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	21067918	95568599	39437917	116	36888										
TRPC6	7225	broad.mit.edu	37	chr11	101341944	101341944	+	Frame_Shift_Del	DEL	T	T	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tctgcatcttcctggaaaccTtttttatggccctggaacag					rs144927067		TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:101341944delT	uc001pgk.3	-	9	2804	c.2379delA	c.(2377-2379)AAAfs	p.K793fs	TRPC6_uc009ywy.2_Frame_Shift_Del_p.K677fs|TRPC6_uc009ywz.1_Frame_Shift_Del_p.K738fs	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	793	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CCTGGAAACCTTTTTTATGGC	0.393																		7	2377	---	---								-	101341944	T	-	101341944	7	5	123	1	0	1	0	1	0	0	0	0	16580	1606	56	0	436	0	TRPC6	11	101341944	Frame_Shift_Del	DEL	T	TCGA-GV-A40E-01A-12D-A23M-08	5773345	101341944	33664572	117	36889										
MMP13	4322	broad.mit.edu	37	chr11	102825997	102825997	+	Frame_Shift_Del	DEL	T	T	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttacctgtaggttaaattcaTtttggaccatttaagagttc							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:102825997delT	uc001phl.2	-	2	374	c.346delA	c.(346-348)ATGfs	p.M116fs		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	116					collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		GTTAAATTCATTTTGGACCAT	0.343																		9	901	---	---								-	102825997	T	-	102825997	7	5	123	1	0	1	0	1	0	0	0	0	9652	1493	52	0	1105	0	MMP13	11	102825997	Frame_Shift_Del	DEL	T	TCGA-GV-A40E-01A-12D-A23M-08	1484053	102825997	32180519	118	36890										
ATM	472	broad.mit.edu	37	chr11	108142128	108142129	+	Frame_Shift_Ins	INS	-	-	T													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttcttacagtaattggagcaINSttttggtaggtacagtctat							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:108142128_108142129insT	uc001pkb.1	+	20	3457_3458	c.3072_3073insT	c.(3070-3075)GCATTTfs	p.A1024fs	ATM_uc009yxr.1_Frame_Shift_Ins_p.A1024fs|ATM_uc009yxs.1_RNA	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1024_1025					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TAATTGGAGCATTTTGGTAGGT	0.381			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)								35	250	---	---								T	108142129	-	T	108142128	7	5	123	1	0	1	1	0	0	0	0	0	1109	204	8	0	3146	0	ATM	11	108142128	Frame_Shift_Ins	INS	-	TCGA-GV-A40E-01A-12D-A23M-08	5316131	108142128	26864388	119	36891										
TECTA	7007	broad.mit.edu	37	chr11	120996394	120996394	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tactgcggcttcctcaacaaGacagacggccctctgtggga	11	13	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:120996394G>C	uc010rzo.1	+	7	1587	c.1587G>C	c.(1585-1587)AAG>AAC	p.K529N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	529	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCCTCAACAAGACAGACGGCC	0.597													0	0	0	0.002836	0	29	189										C	120996394	G	C	120996394	3	2	123	1	0	0	0	0	1	0	0	0	15744	933	33	1	1613	1	TECTA	11	120996394	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	12854266	120996394	14010122	120	36892										
SNX19	399979	broad.mit.edu	37	chr11	130785020	130785020	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgggcagggtgctggatctCtggccttggaaaagataccc	14	10	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr11:130785020C>G	uc001qgk.3	-	1	1363	c.815G>C	c.(814-816)AGA>ACA	p.R272T	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Missense_Mutation_p.R272T|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	272	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		TGCTGGATCTCTGGCCTTGGA	0.547													0	0	0	0.010504	0	20	118										G	130785020	C	G	130785020	3	3	123	1	0	0	0	0	1	0	0	0	14890	913	32	1	2207	1	SNX19	11	130785020	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	9788626	130785020	4221496	121	36893										
KCNA5	3741	broad.mit.edu	37	chr12	5153719	5153719	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgcgctttgagacgcagctgGgcaccctggcgcagttcccc	13	15	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:5153719G>A	uc001qni.2	+	1	635	c.406G>A	c.(406-408)GGC>AGC	p.G136S		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	136						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GACGCAGCTGGGCACCCTGGC	0.677													0	0	0	0.001855	0	14	66										A	5153719	G	A	5153719	3	1	123	1	0	0	0	0	1	0	0	0	8006	1232	43	2	408	2	KCNA5	12	5153719	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		5153719	128698176	122	36894										
VWF	7450	broad.mit.edu	37	chr12	6078463	6078463	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggacctccagctgggggcagGagacgttcctttgttgtata	14	9	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:6078463G>C	uc001qnn.1	-	45	7893	c.7643C>G	c.(7642-7644)TCC>TGC	p.S2548C	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2548					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CTGGGGGCAGGAGACGTTCCT	0.607													0	0	0	0.001168	0	6	84										C	6078463	G	C	6078463	3	2	123	1	0	0	0	0	1	0	0	0	17243	1174	41	1	830	1	VWF	12	6078463	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	924744	6078463	127773432	123	36895										
CD163	9332	broad.mit.edu	37	chr12	7635996	7635996	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgcagcgtcttccttgtgccCacactcactatggccccagc	8	17	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:7635996C>T	uc001qsz.3	-	12	3183	c.3055G>A	c.(3055-3057)GGG>AGG	p.G1019R	CD163_uc001qta.3_Missense_Mutation_p.G1019R|CD163_uc009zfw.2_Missense_Mutation_p.G1052R	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1019	SRCR 9.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TCCTTGTGCCCACACTCACTA	0.537													0	0	0	0.00308	0	7	56										T	7635996	C	T	7635996	3	4	123	1	0	0	0	0	1	0	0	0	2967	594	21	2	435	2	CD163	12	7635996	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1557533	7635996	126215899	124	36896										
SLCO1A2	6579	broad.mit.edu	37	chr12	21427510	21427510	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gcgccaaaatatataggtgcAggaatgccagctacaattga	10	8	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:21427510A>C	uc001rer.2	-	13	1937	c.1686T>G	c.(1684-1686)CCT>CCG	p.P562P	SLCO1A2_uc001res.2_Silent_p.P562P|SLCO1A2_uc010siq.1_Silent_p.P430P|SLCO1A2_uc010sio.1_Silent_p.P430P|SLCO1A2_uc010sip.1_Silent_p.P430P	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	562	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ATATAGGTGCAGGAATGCCAG	0.363													0	0	0	0.006122	0	15	140										C	21427510	A	C	21427510	2	2	123	1	0	0	0	0	0	0	0	1	14722	175	7	5		5	SLCO1A2	12	21427510	Silent	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	13791514	21427510	112424385	125	36897										
SYT10	341359	broad.mit.edu	37	chr12	33579134	33579134	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgcatgtttaattaaatgttCttttaaagcagtttggactt	7	4	1	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:33579134C>G	uc001rll.1	-	2	745	c.448G>C	c.(448-450)GAA>CAA	p.E150Q	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	150	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					ATTAAATGTTCTTTTAAAGCA	0.363													0	0	0	0.003755	0	34	317										G	33579134	C	G	33579134	3	3	123	1	0	0	0	0	1	0	0	0	15463	922	32	1	1147	1	SYT10	12	33579134	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	12151624	33579134	100272761	126	36898										
AMIGO2	347902	broad.mit.edu	37	chr12	47471606	47471606	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaaagctgtgttaaatgcctCatgagcatgggatctgctta	10	7	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:47471606C>G	uc001rpm.2	-	3	1835	c.1180G>C	c.(1180-1182)GAG>CAG	p.E394Q	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Missense_Mutation_p.E394Q|AMIGO2_uc001rpl.2_Missense_Mutation_p.E394Q	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	394	Extracellular (Potential).				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					TTAAATGCCTCATGAGCATGG	0.428													0	0	0	0.010729	0	12	63										G	47471606	C	G	47471606	3	3	123	1	0	0	0	0	1	0	0	0	576	835	29	1	392	1	AMIGO2	12	47471606	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13892472	47471606	86380289	127	36899										
MLL2	8085	broad.mit.edu	37	chr12	49433094	49433094	+	Frame_Shift_Del	DEL	G	G	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaggaccctggccccaggatGgggccactcagcttgcttgg							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:49433094delG	uc001rta.3	-	33	8277	c.8277delC	c.(8275-8277)CCCfs	p.P2759fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2759					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCCCAGGATGGGGCCACTCA	0.602			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)								39	55	---	---								-	49433094	G	-	49433094	7	5	123	1	0	1	0	1	0	0	0	0	9621	1335	47	0	8424	0	MLL2	12	49433094	Frame_Shift_Del	DEL	G	TCGA-GV-A40E-01A-12D-A23M-08	1961488	49433094	84418801	128	36900										
FMNL3	91010	broad.mit.edu	37	chr12	50044479	50044479	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gtatgaatggccctgcagatCtcctcagccgagcggccagc	12	14	2	2	rs118114169	by1000genomes	TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:50044479C>T	uc001ruv.1	-	17	2214	c.1980G>A	c.(1978-1980)GAG>GAA	p.E660E	FMNL3_uc001ruw.1_Silent_p.E609E|FMNL3_uc001rut.1_Silent_p.E226E|FMNL3_uc001ruu.1_Silent_p.E510E	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	660	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						CCCTGCAGATCTCCTCAGCCG	0.592													0	0	0	0.000602	0	5	97										T	50044479	C	T	50044479	2	4	123	1	0	0	0	0	0	0	0	1	5953	912	32	1		1	FMNL3	12	50044479	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	611385	50044479	83807416	129	36901										
SBNO1	55206	broad.mit.edu	37	chr12	123815804	123815804	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cttaccacaatgctcgttttCtactcaacaaataattttca	2	11	3	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr12:123815804C>G	uc010tap.1	-	7	1028	c.1028G>C	c.(1027-1029)AGA>ACA	p.R343T	SBNO1_uc010tao.1_Missense_Mutation_p.R342T|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.R343T|SBNO1_uc001ueu.2_Missense_Mutation_p.R342T|SBNO1_uc001uev.2_Missense_Mutation_p.R341T|SBNO1_uc009zxy.1_Missense_Mutation_p.R308T	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	343							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TGCTCGTTTTCTACTCAACAA	0.289													0	0	0	0.00308	0	6	127										G	123815804	C	G	123815804	3	3	123	1	0	0	0	0	1	0	0	0	13862	913	32	1	3253	1	SBNO1	12	123815804	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	73771325	123815804	10036091	130	36902										
SACS	26278	broad.mit.edu	37	chr13	23913766	23913766	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atgcaccaaaatgattggttCcacagaatcttcaagtaagt	7	8	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr13:23913766C>T	uc001uon.2	-	10	4838	c.4249G>A	c.(4249-4251)GAA>AAA	p.E1417K	SACS_uc001uoo.2_Missense_Mutation_p.E1270K|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1417					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATGATTGGTTCCACAGAATCT	0.368													0	0	0	0.004007	0	16	107										T	23913766	C	T	23913766	3	4	123	1	0	0	0	0	1	0	0	0	13804	864	30	1	9494	1	SACS	13	23913766	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08		23913766	91256112	131	36903										
NAA16	79612	broad.mit.edu	37	chr13	41946363	41946363	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaaatccattagaggaagccGttaagttccttatacctctt	6	9	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr13:41946363G>A	uc001uyf.2	+	16	2296	c.1972G>A	c.(1972-1974)GTT>ATT	p.V658I	NAA16_uc010tfg.1_Intron	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	658					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						AGAGGAAGCCGTTAAGTTCCT	0.279													0	0	0	0.00361	0	62	34										A	41946363	G	A	41946363	3	1	123	1	0	0	0	0	1	0	0	0	10119	1145	40	2	2067	2	NAA16	13	41946363	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	18032597	41946363	73223515	132	36904										
LRP10	26020	broad.mit.edu	37	chr14	23344898	23344898	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttgggctttggagatgcagtGcatgtgtatgacggccctgg	16	7	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:23344898G>A	uc001whd.2	+	5	1294	c.741G>A	c.(739-741)GTG>GTA	p.V247V	LRP10_uc001whe.2_Silent_p.V123V	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	247	CUB 2.|Extracellular (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GAGATGCAGTGCATGTGTATG	0.627													0	0	0	0.010729	0	11	80										A	23344898	G	A	23344898	2	1	123	1	0	0	0	0	0	0	0	1	8952	1306	46	2		2	LRP10	14	23344898	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		23344898	84004642	133	36905										
ACIN1	22985	broad.mit.edu	37	chr14	23548778	23548778	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttctgctgttgcttgatgctGaacgagaacgtgaacgtgac	12	8	1	5			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:23548778G>A	uc001wit.3	-	6	2268	c.1940C>T	c.(1939-1941)TCA>TTA	p.S647L	ACIN1_uc001wis.3_Missense_Mutation_p.S329L|ACIN1_uc010akg.2_Missense_Mutation_p.S647L|ACIN1_uc010tnj.1_Missense_Mutation_p.S607L	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	647	Ser-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GCTTGATGCTGAACGAGAACG	0.498													0	0	0	0.00361	0	54	582										A	23548778	G	A	23548778	3	1	123	1	0	0	0	0	1	0	0	0	142	1294	45	1	2288	1	ACIN1	14	23548778	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	203880	23548778	83800762	134	36906										
NYNRIN	57523	broad.mit.edu	37	chr14	24878129	24878129	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggatcaatgagctgcattctCtacatctggcctggctcctg	10	12	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:24878129C>T	uc001wpf.3	+	4	1447	c.1129C>T	c.(1129-1131)CTA>TTA	p.L377L		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	377					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GCTGCATTCTCTACATCTGGC	0.602													0	0	0	0.008291	0	11	27										T	24878129	C	T	24878129	2	4	123	1	0	0	0	0	0	0	0	1	10796	912	32	1		1	NYNRIN	14	24878129	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1329351	24878129	82471411	135	36907										
FANCM	57697	broad.mit.edu	37	chr14	45658163	45658163	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aagtataaaactcgacgtgcAgtaatgctaaaagaaatgat	8	5	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:45658163A>C	uc001wwd.3	+	20	5037	c.4938A>C	c.(4936-4938)GCA>GCC	p.A1646A	FANCM_uc010anf.2_Silent_p.A1620A|FANCM_uc001wwe.3_Silent_p.A1182A|FANCM_uc010ang.2_Silent_p.A860A	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1646					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						CTCGACGTGCAGTAATGCTAA	0.318								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.008871	0	19	82										C	45658163	A	C	45658163	2	2	123	1	0	0	0	0	0	0	0	1	5671	175	7	5		5	FANCM	14	45658163	Silent	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	20780034	45658163	61691377	136	36908										
PSMC6	5706	broad.mit.edu	37	chr14	53190725	53190725	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttcggatggctttaatggagCagatctgagaaatgtttgta	12	4	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:53190725C>G	uc010tqx.1	+	13	1064	c.1064C>G	c.(1063-1065)GCA>GGA	p.A355G	PSMC6_uc001wzy.2_RNA	NM_002806	NP_002797	P62333	PRS10_HUMAN	proteasome 26S ATPase subunit 6	341					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			lung(1)	1	Breast(41;0.176)					TTTAATGGAGCAGATCTGAGA	0.279													0	0	0	0.001984	0	7	97										G	53190725	C	G	53190725	3	3	123	1	0	0	0	0	1	0	0	0	12691	710	25	4	1114	4	PSMC6	14	53190725	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	7532562	53190725	54158815	137	36909										
RTN1	6252	broad.mit.edu	37	chr14	60193839	60193839	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gttgaggggtagtcgaggaaGgaacccggctcggccaggcc	18	10	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:60193839G>T	uc001xen.1	-	3	1772	c.1563C>A	c.(1561-1563)TCC>TCA	p.S521S	RTN1_uc001xem.1_Silent_p.S101S	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	521					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		AGTCGAGGAAGGAACCCGGCT	0.721													1	0	0.004672	0.004672	0.00475916	3	8										T	60193839	G	T	60193839	2	4	123	1	0	0	0	0	0	0	0	1	13725	987	35	4		4	RTN1	14	60193839	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	7003114	60193839	47155701	138	36910										
COX16	51241	broad.mit.edu	37	chr14	70793096	70793096	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctggatttcttccttggaggAggtcaggatcttcccaaggc	12	10	3	0	rs139121123		TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:70793096A>C	uc001xmb.2	-	4	415	c.275T>G	c.(274-276)CTC>CGC	p.L92R		NM_016468	NP_057552	Q9P0S2	COX16_HUMAN	COX16 cytochrome c oxidase assembly homolog	92						integral to membrane|mitochondrial membrane					0						TCCTTGGAGGAGGTCAGGATC	0.328													0	0	0	0.009096	0	4	45										C	70793096	A	C	70793096	3	2	123	1	0	0	0	0	1	0	0	0	3765	304	11	5	49	5	COX16	14	70793096	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	10599257	70793096	36556444	139	36911										
NRXN3	9369	broad.mit.edu	37	chr14	79432421	79432421	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tccacaacattgaaacgggaAtcatgactgagaaacgctac	8	10	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:79432421A>G	uc001xun.2	+	9	1821	c.1330A>G	c.(1330-1332)ATC>GTC	p.I444V	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.I569V	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	817	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGAAACGGGAATCATGACTGA	0.433													0	0	0	0.00361	0	53	37										G	79432421	A	G	79432421	3	3	123	1	0	0	0	0	1	0	0	0	10667	101	4	5	1356	5	NRXN3	14	79432421	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	8639325	79432421	27917119	140	36912										
FLRT2	23768	broad.mit.edu	37	chr14	86088385	86088385	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tcacctgagcagtgtgcctgTtgggcttcctgtggacttgc	13	11	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:86088385T>C	uc001xvr.2	+	2	1294	c.527T>C	c.(526-528)GTT>GCT	p.V176A	FLRT2_uc010atd.2_Missense_Mutation_p.V176A	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	176	Extracellular (Potential).|LRR 5.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AGTGTGCCTGTTGGGCTTCCT	0.502													0	0	0	0.013114	0	48	58										C	86088385	T	C	86088385	3	2	123	1	0	0	0	0	1	0	0	0	5939	1725	60	5	529	5	FLRT2	14	86088385	Missense_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	6655964	86088385	21261155	141	36913										
WDR20	91833	broad.mit.edu	37	chr14	102675837	102675837	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	attcagcagtctcaaatgctGgcagcaaaagcagtgtcatg	10	9	3	0	rs12888595	byFrequency	TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:102675837G>T	uc001ykz.2	+	3	1379	c.1330G>T	c.(1330-1332)GGC>TGC	p.G444C	WDR20_uc001yky.1_Missense_Mutation_p.G187C|WDR20_uc001yla.2_Missense_Mutation_p.G320C|WDR20_uc001ylb.2_Missense_Mutation_p.G383C|WDR20_uc010txu.1_Missense_Mutation_p.G475C|WDR20_uc001ylc.2_Intron|WDR20_uc001yld.2_Missense_Mutation_p.G444C|WDR20_uc001yle.2_Missense_Mutation_p.G383C|WDR20_uc001ylf.2_Missense_Mutation_p.G456C	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	444											0						CTCAAATGCTGGCAGCAAAAG	0.537											OREG0022939	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.59834e-05	0.001168	3.73515e-05	6	104										T	102675837	G	T	102675837	3	4	123	1	0	0	0	0	1	0	0	0	17277	1348	47	4	1357	4	WDR20	14	102675837	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	16587452	102675837	4673703	142	36914										
AHNAK2	113146	broad.mit.edu	37	chr14	105408168	105408168	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggcaggtgccctttgaggccGgctacctcgggcatgtggcc	16	13	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr14:105408168G>A	uc010axc.1	-	7	13740	c.13620C>T	c.(13618-13620)GCC>GCT	p.A4540A	AHNAK2_uc001ypx.2_Silent_p.A4440A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4540						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTTTGAGGCCGGCTACCTCGG	0.632													0	0	0	0.00361	0	53	174										A	105408168	G	A	105408168	2	1	123	1	0	0	0	0	0	0	0	1	415	1103	39	2		2	AHNAK2	14	105408168	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	2732331	105408168	1941372	143	36915										
APBA2	321	broad.mit.edu	37	chr15	29346684	29346684	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	taccaggactactaccccgaGgaggccaacgggaacaccgg	12	14	0	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:29346684G>A	uc001zck.2	+	3	804	c.597G>A	c.(595-597)GAG>GAA	p.E199E	APBA2_uc010azj.2_Silent_p.E199E|APBA2_uc010uat.1_Silent_p.E199E|APBA2_uc001zcl.2_Silent_p.E199E|APBA2_uc010uas.1_Silent_p.E199E	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	199	STXBP1-binding.			DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		ACTACCCCGAGGAGGCCAACG	0.627													0	0	0	0.001168	0	6	23										A	29346684	G	A	29346684	2	1	123	1	0	0	0	0	0	0	0	1	757	991	35	2		2	APBA2	15	29346684	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		29346684	73184708	144	36916										
CASC5	57082	broad.mit.edu	37	chr15	40916744	40916744	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tatcttttaagcttccaaagGatcaaatgaaagtctatgtt	6	6	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:40916744G>C	uc010bbs.1	+	11	4521	c.4360G>C	c.(4360-4362)GAT>CAT	p.D1454H	CASC5_uc010ucq.1_Missense_Mutation_p.D1278H|CASC5_uc001zme.2_Missense_Mutation_p.D1428H|CASC5_uc010bbt.1_Missense_Mutation_p.D1428H	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	1454					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		GCTTCCAAAGGATCAAATGAA	0.358													0	0	0	0.004482	0	7	144										C	40916744	G	C	40916744	3	2	123	1	0	0	0	0	1	0	0	0	2663	1174	41	1	4398	1	CASC5	15	40916744	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	11570060	40916744	61614648	145	36917										
RAD51	5888	broad.mit.edu	37	chr15	41020994	41020994	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	accagacccagctcctttatCaagcatcagccatgatggta	7	13	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:41020994C>G	uc001zmi.3	+	7	915	c.616C>G	c.(616-618)CAA>GAA	p.Q206E	RAD51_uc010bbw.2_Missense_Mutation_p.Q206E|RAD51_uc010bbx.2_Missense_Mutation_p.Q207E|RAD51_uc001zmk.3_RNA|RAD51_uc001zml.3_Missense_Mutation_p.Q207E	NM_002875	NP_002866	Q06609	RAD51_HUMAN	RAD51 homolog protein isoform 1	206	Interaction with PALB2.				DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity				0		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		GCTCCTTTATCAAGCATCAGC	0.443								Homologous_recombination					0	0	0	0.004878	0	34	199										G	41020994	C	G	41020994	3	3	123	1	0	0	0	0	1	0	0	0	12985	827	29	1	763	1	RAD51	15	41020994	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	104250	41020994	61510398	146	36918										
MGA	23269	broad.mit.edu	37	chr15	42054514	42054514	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cagatgtttataaataacagGagggggaaacctttgattct	10	5	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:42054514G>A	uc010ucy.1	+	22	7879	c.7698G>A	c.(7696-7698)AGG>AGA	p.R2566R	MGA_uc010ucz.1_Silent_p.R2357R|MGA_uc010uda.1_Silent_p.R1182R	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2527						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TAAATAACAGGAGGGGGAAAC	0.403													0	0	0	0.00245	0	15	64										A	42054514	G	A	42054514	2	1	123	1	0	0	0	0	0	0	0	1	9540	1165	41	1		1	MGA	15	42054514	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1033520	42054514	60476878	147	36919										
AQP9	366	broad.mit.edu	37	chr15	58465375	58465375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gttcttgggagcctttgtggGggctgcaaccgtctttggca	15	9	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:58465375G>A	uc002aez.2	+	3	704	c.347G>A	c.(346-348)GGG>GAG	p.G116E	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Missense_Mutation_p.G51E	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	116	Helical; (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		GCCTTTGTGGGGGCTGCAACC	0.453													0	0	0	0.002836	0	34	158										A	58465375	G	A	58465375	3	1	123	1	0	0	0	0	1	0	0	0	833	1232	43	2	357	2	AQP9	15	58465375	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	16410861	58465375	44066017	148	36920										
ZNF609	23060	broad.mit.edu	37	chr15	64968122	64968122	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cagcagcggggagtggacaaGaaggcagagatgggcctgaa	18	7	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:64968122G>A	uc002ann.2	+	4	3069	c.3069G>A	c.(3067-3069)AAG>AAA	p.K1023K		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	1023						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GAGTGGACAAGAAGGCAGAGA	0.577													0	0	0	0.002299	0	24	132										A	64968122	G	A	64968122	2	1	123	1	0	0	0	0	0	0	0	1	18032	933	33	1		1	ZNF609	15	64968122	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	6502747	64968122	37563270	149	36921										
SCAPER	49855	broad.mit.edu	37	chr15	76995194	76995194	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttgatataacaacctaccagGacattgcagagagaacactg	8	9	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:76995194G>A	uc002bby.2	-	18	2456	c.2397C>T	c.(2395-2397)GTC>GTT	p.V799V	SCAPER_uc010bkr.2_Silent_p.V107V|SCAPER_uc002bbx.2_Silent_p.V553V|SCAPER_uc002bbz.1_Silent_p.V670V|SCAPER_uc002bca.1_Silent_p.V664V|SCAPER_uc002bcb.1_Silent_p.V805V	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	798	C2H2-type.					endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AACCTACCAGGACATTGCAGA	0.368													0	0	0	0.001168	0	6	131										A	76995194	G	A	76995194	2	1	123	1	0	0	0	0	0	0	0	1	13878	1161	41	1		1	SCAPER	15	76995194	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	12027072	76995194	25536198	150	36922										
IREB2	3658	broad.mit.edu	37	chr15	78790483	78790483	+	Nonstop_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttgtggcacgaaaattctcaTagtatctacttaccatagat	6	8	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:78790483T>C	uc002bdr.2	+	22	3052	c.2890T>C	c.(2890-2892)TAG>CAG	p.*964Q	IREB2_uc010unb.1_Nonstop_Mutation_p.*714Q	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	964							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AAAATTCTCATAGTATCTACT	0.388													0	0	0	0.006214	0	10	66										C	78790483	T	C	78790483	4	2	123	1	0	0	0	0	0	0	0	0	7826	1419	49	5	2976	5	IREB2	15	78790483	Nonstop_Mutation	SNP	T	TCGA-GV-A40E-01A-12D-A23M-08	1795289	78790483	23740909	151	36923										
NTRK3	4916	broad.mit.edu	37	chr15	88670429	88670429	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tctggtttgtgggtcacagtGataggaggtgtgggactcac	16	6	3	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr15:88670429G>A	uc002bme.1	-	11	1419	c.1257C>T	c.(1255-1257)ATC>ATT	p.I419I	NTRK3_uc002bmh.2_Silent_p.I411I|NTRK3_uc002bmf.1_Silent_p.I419I|NTRK3_uc010upl.1_Silent_p.I321I|NTRK3_uc010bnh.1_Silent_p.I411I|NTRK3_uc002bmg.2_Silent_p.I419I	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	419	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGTCACAGTGATAGGAGGTG	0.498			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.001168	0	4	28										A	88670429	G	A	88670429	2	1	123	1	0	0	0	0	0	0	0	1	10708	1280	45	1		1	NTRK3	15	88670429	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	9879946	88670429	13860963	152	36924										
TMEM8A	58986	broad.mit.edu	37	chr16	427570	427570	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gggttgatgaccggaggggcGccggaacggaagtgcctgga	20	8	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr16:427570G>A	uc002cgu.3	-	3	444	c.315C>T	c.(313-315)GGC>GGT	p.G105G	TMEM8A_uc002cgv.3_5'UTR	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	105	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3						CCGGAGGGGCGCCGGAACGGA	0.711													0	0	0	0.009096	0	4	5										A	427570	G	A	427570	2	1	123	1	0	0	0	0	0	0	0	1	16211	1074	38	2		2	TMEM8A	16	427570	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		427570	89927183	153	36925										
MMP2	4313	broad.mit.edu	37	chr16	55539318	55539318	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	caaagtctgaagagcgtgaaGtttggaagcatcaaatccga	11	7	2	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr16:55539318G>T	uc002ehz.3	+	13	2258	c.1947G>T	c.(1945-1947)AAG>AAT	p.K649N	MMP2_uc010vhd.1_Missense_Mutation_p.K573N|MMP2_uc010ccc.2_Missense_Mutation_p.K599N|MMP2_uc002eia.3_Missense_Mutation_p.K146N	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	649	Required for inhibitor TIMP2 binding.|Hemopexin-like 4.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGAGCGTGAAGTTTGGAAGCA	0.552													1	0	3.5997e-14	0.002299	4.02753e-14	21	165										T	55539318	G	T	55539318	3	4	123	1	0	0	0	0	1	0	0	0	9658	1020	36	4	2004	4	MMP2	16	55539318	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	55111748	55539318	34815435	154	36926										
NFAT5	10725	broad.mit.edu	37	chr16	69681191	69681191	+	Frame_Shift_Del	DEL	A	A	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cacctgaggacttgctggatAacagtcggatgtcctgccag							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr16:69681191delA	uc002exm.1	+	3	1668	c.460delA	c.(460-462)AACfs	p.N154fs	NFAT5_uc002exh.1_Intron|NFAT5_uc002exi.2_Frame_Shift_Del_p.N78fs|NFAT5_uc002exj.1_Frame_Shift_Del_p.N78fs|NFAT5_uc002exk.1_Frame_Shift_Del_p.N78fs|NFAT5_uc002exl.1_Frame_Shift_Del_p.N172fs|NFAT5_uc002exn.1_Frame_Shift_Del_p.N172fs	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	154					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CTTGCTGGATAACAGTCGGAT	0.502																		14	115	---	---								-	69681191	A	-	69681191	7	5	123	1	0	1	0	1	0	0	0	0	10360	362	13	0	528	0	NFAT5	16	69681191	Frame_Shift_Del	DEL	A	TCGA-GV-A40E-01A-12D-A23M-08	14141873	69681191	20673562	155	36927										
ADAMTS18	170692	broad.mit.edu	37	chr16	77465452	77465452	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cctgccgttgtgcaaaatgtCgtgtgaaatatatgacccgg	11	9	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr16:77465452C>G	uc002ffc.3	-	3	654	c.235G>C	c.(235-237)GAC>CAC	p.D79H	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	79					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGCAAAATGTCGTGTGAAATA	0.488													0	0	0	0.00361	0	125	303										G	77465452	C	G	77465452	3	3	123	1	0	0	0	0	1	0	0	0	263	884	31	1	3514	1	ADAMTS18	16	77465452	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	7784261	77465452	12889301	156	36928										
ATMIN	23300	broad.mit.edu	37	chr16	81077964	81077964	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgacacaaatcctggacctGacacccagctcccatctggc	7	17	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr16:81077964G>C	uc002ffz.1	+	4	1879	c.1861G>C	c.(1861-1863)GAC>CAC	p.D621H	ATMIN_uc002fga.2_Missense_Mutation_p.D463H|ATMIN_uc010vnn.1_Missense_Mutation_p.D392H|ATMIN_uc002fgb.1_Missense_Mutation_p.D463H	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	621					response to DNA damage stimulus	nucleus	zinc ion binding				0						TCCTGGACCTGACACCCAGCT	0.443													0	0	0	0.001168	0	4	59										C	81077964	G	C	81077964	3	2	123	1	0	0	0	0	1	0	0	0	1110	1290	45	1	1875	1	ATMIN	16	81077964	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	3612512	81077964	9276789	157	36929										
TRPV3	162514	broad.mit.edu	37	chr17	3438937	3438937	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gcgtgcgcgttgacgtcggcGccggcggcgatgagcagggc	20	12	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:3438937G>A	uc002fvt.1	-	7	1036	c.714C>T	c.(712-714)GGC>GGT	p.G238G	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Silent_p.G222G|TRPV3_uc010vri.1_Silent_p.G193G|TRPV3_uc010vrj.1_Silent_p.G222G|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Silent_p.G222G|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Silent_p.G238G|TRPV3_uc002fvu.2_Silent_p.G238G	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	238	Cytoplasmic (Potential).|ANK 1.					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	TGACGTCGGCGCCGGCGGCGA	0.721													0	0	0	0.001168	0	5	21										A	3438937	G	A	3438937	2	1	123	1	0	0	0	0	0	0	0	1	16594	1074	38	2		2	TRPV3	17	3438937	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		3438937	77756273	158	36930										
KIAA0100	9703	broad.mit.edu	37	chr17	26962026	26962026	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggagtgggacagggcttggaGaggcccaagcacgagtccct	17	10	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:26962026G>A	uc002hbu.2	-	16	2678	c.2579C>T	c.(2578-2580)TCT>TTT	p.S860F		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	860						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGGGCTTGGAGAGGCCCAAGC	0.468													0	0	0	0.00361	0	127	289										A	26962026	G	A	26962026	3	1	123	1	0	0	0	0	1	0	0	0	8154	942	33	1	4224	1	KIAA0100	17	26962026	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	23523089	26962026	54233184	159	36931										
NF1	4763	broad.mit.edu	37	chr17	29554622	29554622	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aagccaaaatggaagatggcCaggtaagtctgtaaagttga	12	5	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:29554622C>G	uc002hgg.2	+	20	2740	c.2407C>G	c.(2407-2409)CAG>GAG	p.Q803E	NF1_uc002hgh.2_Missense_Mutation_p.Q803E|NF1_uc010csn.1_Missense_Mutation_p.Q663E|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	803					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GGAAGATGGCCAGGTAAGTCT	0.353			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.001168	0	6	107										G	29554622	C	G	29554622	3	3	123	1	0	0	0	0	1	0	0	0	10356	595	21	4	2546	4	NF1	17	29554622	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	2592596	29554622	51640588	160	36932										
NF1	4763	broad.mit.edu	37	chr17	29664524	29664524	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ccgggacaggtcattctctcCtggctcctatgagagagaga	12	11	2	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:29664524C>G	uc002hgg.2	+	43	6899	c.6566C>G	c.(6565-6567)CCT>CGT	p.P2189R	NF1_uc002hgh.2_Missense_Mutation_p.P2168R|NF1_uc010cso.2_Missense_Mutation_p.P377R|NF1_uc010wbt.1_5'Flank|NF1_uc010wbu.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2189					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCATTCTCTCCTGGCTCCTAT	0.433			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.00499	0	17	197										G	29664524	C	G	29664524	3	3	123	1	0	0	0	0	1	0	0	0	10356	681	24	4	6797	4	NF1	17	29664524	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	109902	29664524	51530686	161	36933										
GAS2L2	246176	broad.mit.edu	37	chr17	34073205	34073206	+	Frame_Shift_Ins	INS	-	-	G													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	caatggctcggagtctttgtINSggggtggggttcccggcgtc							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:34073205_34073206insG	uc002hjv.1	-	6	1338_1339	c.1310_1311insC	c.(1309-1311)CCAfs	p.P437fs		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	437					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGAGTCTTTGTGGGGTGGGGTT	0.599																		8	298	---	---								G	34073206	-	G	34073205	7	5	123	1	0	1	1	0	0	0	0	0	6247	1683	59	0	1335	0	GAS2L2	17	34073205	Frame_Shift_Ins	INS	-	TCGA-GV-A40E-01A-12D-A23M-08	4408681	34073205	47122005	162	36934										
TAF15	8148	broad.mit.edu	37	chr17	34149829	34149829	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aagggaaaactacagccaccAcacacaaggtaagatttact	7	10	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:34149829A>G	uc002hkd.2	+	6	562	c.476A>G	c.(475-477)CAC>CGC	p.H159R	TAF15_uc010ctw.1_RNA|TAF15_uc002hkc.2_Missense_Mutation_p.H156R	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	159	Gln/Gly/Ser/Tyr-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		TACAGCCACCACACACAAGGT	0.378			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								0	0	0	0.00245	0	12	160										G	34149829	A	G	34149829	3	3	123	1	0	0	0	0	1	0	0	0	15515	159	6	5	498	5	TAF15	17	34149829	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	76624	34149829	47045381	163	36935										
ACACA	31	broad.mit.edu	37	chr17	35486362	35486362	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgggaacaaactcgatgattCtgtctataggatcctttgag	10	7	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:35486362C>G	uc002hnm.2	-	47	5953	c.5762G>C	c.(5761-5763)AGA>ACA	p.R1921T	ACACA_uc002hnk.2_Missense_Mutation_p.R1843T|ACACA_uc002hnl.2_Missense_Mutation_p.R1863T|ACACA_uc002hnn.2_Missense_Mutation_p.R1921T|ACACA_uc002hno.2_Missense_Mutation_p.R1958T|ACACA_uc010cuy.2_Missense_Mutation_p.R566T|ACACA_uc010wdc.1_Missense_Mutation_p.R47T	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1921	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCGATGATTCTGTCTATAGG	0.478													0	0	0	0.001984	0	7	67										G	35486362	C	G	35486362	3	3	123	1	0	0	0	0	1	0	0	0	106	913	32	1	1318	1	ACACA	17	35486362	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1336533	35486362	45708848	164	36936										
MLLT6	4302	broad.mit.edu	37	chr17	36876912	36876912	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgtgacatccctcccacagCcggcagcagcgactccttga	9	17	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:36876912C>G	uc002hqi.3	+	16	2367	c.2354C>G	c.(2353-2355)GCC>GGC	p.A785G	MLLT6_uc002hqj.2_Missense_Mutation_p.A220G|MLLT6_uc002hqk.3_Missense_Mutation_p.A116G	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	785					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					CCTCCCACAGCCGGCAGCAGC	0.667			T	MLL	AL								0	0	0	0.00308	0	7	111										G	36876912	C	G	36876912	3	3	123	1	0	0	0	0	1	0	0	0	9630	753	26	4	2416	4	MLLT6	17	36876912	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1390550	36876912	44318298	165	36937										
CCR7	1236	broad.mit.edu	37	chr17	38711197	38711197	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gcggacgcaggccaggctgtAggtgacgtcgtaggcgatgt	18	9	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:38711197A>G	uc002huw.2	-	3	997	c.934T>C	c.(934-936)TAC>CAC	p.Y312H		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	312	Extracellular (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				GCCAGGCTGTAGGTGACGTCG	0.567													0	0	0	0.00245	0	13	122										G	38711197	A	G	38711197	3	3	123	1	0	0	0	0	1	0	0	0	2946	420	15	5	206	5	CCR7	17	38711197	Missense_Mutation	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08	1834285	38711197	42484013	166	36938										
SMARCE1	6605	broad.mit.edu	37	chr17	38788611	38788611	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atgcttcattgaaaagccatCatcataatctggagtgaaca	7	8	4	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:38788611C>T	uc002hux.2	-	8	674	c.550G>A	c.(550-552)GAT>AAT	p.D184N	SMARCE1_uc010wff.1_Missense_Mutation_p.D149N|SMARCE1_uc010wfg.1_Missense_Mutation_p.D114N|SMARCE1_uc002huy.2_Missense_Mutation_p.D149N|SMARCE1_uc010wfh.1_Missense_Mutation_p.D114N|SMARCE1_uc010wfi.1_Missense_Mutation_p.D166N	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	184					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				GAAAAGCCATCATCATAATCT	0.433													0	0	0	0.004878	0	35	67										T	38788611	C	T	38788611	3	4	123	1	0	0	0	0	1	0	0	0	14780	826	29	1	701	1	SMARCE1	17	38788611	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	77414	38788611	42406599	167	36939										
TMEM99	147184	broad.mit.edu	37	chr17	38991162	38991162	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tcagtctctctcaagggtctCacgttgcagcattcttacca	7	13	5	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:38991162C>G	uc002hvj.1	+	3	701	c.394C>G	c.(394-396)CAC>GAC	p.H132D		NM_145274	NP_660317	Q8N816	TMM99_HUMAN	transmembrane protein 99 precursor	132						integral to membrane				skin(1)	1		Breast(137;0.000301)				TCAAGGGTCTCACGTTGCAGC	0.512													0	0	0	0.003163	0	16	269										G	38991162	C	G	38991162	3	3	123	1	0	0	0	0	1	0	0	0	16223	826	29	1	396	1	TMEM99	17	38991162	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	202551	38991162	42204048	168	36940										
KRTAP4-11	653240	broad.mit.edu	37	chr17	39274518	39274518	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aggtctcctggcagaggtctCggccacagccttggtgagag	15	11	2	2	rs9897031	by1000genomes	TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:39274518C>T	uc002hvz.2	-	1	89	c.50G>A	c.(49-51)CGA>CAA	p.R17Q		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	17	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].			R -> Q (in Ref. 1; CAC27583 and 3; AAI26132/AAI30563).		keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGAGGTCTCGGCCACAGCC	0.592													0	0	0	0.001168	0	5	69										T	39274518	C	T	39274518	3	4	123	1	0	0	0	0	1	0	0	0	8549	884	31	1	541	1	KRTAP4-11	17	39274518	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	283356	39274518	41920692	169	36941										
CDC27	996	broad.mit.edu	37	chr17	45214642	45214642	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggcataagcgtaatttggatCaacttggatagctctctgga	11	7	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:45214642C>G	uc002ild.3	-	14	1916	c.1789G>C	c.(1789-1791)GAT>CAT	p.D597H	CDC27_uc002ile.3_Missense_Mutation_p.D603H|CDC27_uc002ilf.3_Missense_Mutation_p.D596H|CDC27_uc010wkp.1_Missense_Mutation_p.D536H|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	597	TPR 4.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						TAATTTGGATCAACTTGGATA	0.393													0	0	0	0.00308	0	7	64										G	45214642	C	G	45214642	3	3	123	1	0	0	0	0	1	0	0	0	3066	826	29	1	709	1	CDC27	17	45214642	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	5940124	45214642	35980568	170	36942										
USP32	84669	broad.mit.edu	37	chr17	58372085	58372085	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgtatctgggactttaccatCcaccacgtggagcattcttt	8	11	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:58372085C>T	uc002iyo.1	-	4	656	c.370G>A	c.(370-372)GAT>AAT	p.D124N	USP32_uc010wov.1_Missense_Mutation_p.D124N	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	124	EF-hand 1.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACTTTACCATCCACCACGTGG	0.338													0	0	0	0.001368	0	12	100										T	58372085	C	T	58372085	3	4	123	1	0	0	0	0	1	0	0	0	17060	855	30	1	4568	1	USP32	17	58372085	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13157443	58372085	22823125	171	36943										
EFCAB3	146779	broad.mit.edu	37	chr17	60493466	60493466	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gaggggatttgattgggatgGactctagaaatgagtccttt	14	4	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:60493466G>C	uc002izu.1	+	10	1171	c.1093G>C	c.(1093-1095)GAC>CAC	p.D365H	EFCAB3_uc010wpc.1_Missense_Mutation_p.D417H	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	365							calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			GATTGGGATGGACTCTAGAAA	0.398													0	0	0	0.006122	0	17	120										C	60493466	G	C	60493466	3	2	123	1	0	0	0	0	1	0	0	0	4935	1174	41	1	1295	1	EFCAB3	17	60493466	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	2121381	60493466	20701744	172	36944										
RECQL5	9400	broad.mit.edu	37	chr17	73625043	73625043	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tccctgaggcactcctcagtCtggggaggggcaggcgaatg	16	11	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:73625043C>A	uc010dgl.2	-	16	2616	c.2460G>T	c.(2458-2460)CAG>CAT	p.Q820H	RECQL5_uc010dgk.2_Missense_Mutation_p.Q793H|RECQL5_uc002jot.3_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	820					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			ACTCCTCAGTCTGGGGAGGGG	0.617								Other_identified_genes_with_known_or_suspected_DNA_repair_function					1	0	2.17888e-05	0.006214	2.27906e-05	8	89										A	73625043	C	A	73625043	3	1	123	1	0	0	0	0	1	0	0	0	13203	912	32	3	535	3	RECQL5	17	73625043	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	13131577	73625043	7570167	173	36945										
PGS1	9489	broad.mit.edu	37	chr17	76411074	76411074	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggcccagattgcgatcgtgaCggagaaccaggccctgcagc	14	13	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr17:76411074C>G	uc002jvm.2	+	8	1529	c.1517C>G	c.(1516-1518)ACG>AGG	p.T506R	PGS1_uc010wtt.1_RNA|PGS1_uc010dho.2_RNA|PGS1_uc002jvn.2_Missense_Mutation_p.T219R|PGS1_uc002jvo.2_RNA|PGS1_uc002jvp.1_Missense_Mutation_p.T219R	NM_024419	NP_077733	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	506					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			GCGATCGTGACGGAGAACCAG	0.632													0	0	0	0.006214	0	9	70										G	76411074	C	G	76411074	3	3	123	1	0	0	0	0	1	0	0	0	11808	536	19	4	1547	4	PGS1	17	76411074	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	2786031	76411074	4784136	174	36946										
ASXL3	80816	broad.mit.edu	37	chr18	31326430	31326430	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tttgccgacagcagcaatgcAgatgaattggaactgaaatg	11	7	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr18:31326430A>T	uc010dmg.1	+	12	6673	c.6618A>T	c.(6616-6618)GCA>GCT	p.A2206A	ASXL3_uc002kxq.2_Silent_p.A1913A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCAGCAATGCAGATGAATTGG	0.517													0	0	0	0.001168	0	5	77										T	31326430	A	T	31326430	2	4	123	1	0	0	0	0	0	0	0	1	1068	175	7	5		5	ASXL3	18	31326430	Silent	SNP	A	TCGA-GV-A40E-01A-12D-A23M-08		31326430	46750818	175	36947										
SYT4	6860	broad.mit.edu	37	chr18	40851688	40851688	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cattcttacctgaaagtccgGacacatcagatttaggcaga	8	10	2	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr18:40851688G>C	uc002law.2	-	3	1328	c.959C>G	c.(958-960)TCC>TGC	p.S320C	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.S302C|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	320	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						TGAAAGTCCGGACACATCAGA	0.423													0	0	0	0.003163	0	13	99										C	40851688	G	C	40851688	3	2	123	1	0	0	0	0	1	0	0	0	15473	1174	41	1	326	1	SYT4	18	40851688	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	9525258	40851688	37225560	176	36948										
HMHA1	23526	broad.mit.edu	37	chr19	1080305	1080305	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttcaacgtgagtgatgtggcGcggccggaggctgccgggag	19	9	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:1080305G>A	uc002lqz.1	+	14	1986	c.1755G>A	c.(1753-1755)GCG>GCA	p.A585A	HMHA1_uc010xgd.1_Silent_p.A601A|HMHA1_uc010xge.1_Silent_p.A425A|HMHA1_uc002lra.1_Silent_p.A425A|HMHA1_uc002lrb.1_Silent_p.A468A|HMHA1_uc002lrc.1_Silent_p.A220A|HMHA1_uc002lrd.1_5'Flank|HMHA1_uc010dsd.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	585					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGATGTGGCGCGGCCGGAGG	0.677													0	0	0	0.007291	0	29	111										A	1080305	G	A	1080305	2	1	123	1	0	0	0	0	0	0	0	1	7240	1074	38	2		2	HMHA1	19	1080305	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		1080305	58048678	177	36949										
REXO1	57455	broad.mit.edu	37	chr19	1817224	1817224	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gagaacagcctcaccatctcGcagtccagggcgtagatccc	10	15	2	2	rs141798167		TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:1817224G>A	uc002lua.3	-	12	3290	c.3195C>T	c.(3193-3195)TGC>TGT	p.C1065C	REXO1_uc010dsq.2_Silent_p.C374C|REXO1_uc010xgs.1_Silent_p.C51C|MIR1909_hsa-mir-1909|MI0008330_5'Flank|REXO1_uc010dsp.1_RNA	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	1065	Exonuclease.					nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCACCATCTCGCAGTCCAGGG	0.647													0	0	0	0.005443	0	21	35										A	1817224	G	A	1817224	2	1	123	1	0	0	0	0	0	0	0	1	13241	1079	38	2		2	REXO1	19	1817224	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	736919	1817224	57311759	178	36950										
SLC39A3	29985	broad.mit.edu	37	chr19	2733469	2733469	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gtgctgatgtggccgaggctCaggaccttctggagctgcag	16	10	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:2733469C>G	uc002lwg.2	-	3	479	c.225G>C	c.(223-225)CTG>CTC	p.L75L	SLC39A3_uc010xgy.1_Silent_p.L75L	NM_144564	NP_653165	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter),	75	Extracellular (Potential).					integral to membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGAGGCTCAGGACCTTCT	0.632													0	0	0	0.00308	0	7	84										G	2733469	C	G	2733469	2	3	123	1	0	0	0	0	0	0	0	1	14619	813	29	1		1	SLC39A3	19	2733469	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	916245	2733469	56395514	179	36951										
DOCK6	57572	broad.mit.edu	37	chr19	11313296	11313296	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	atctctgccagcttcgtgatCgatggctccttgtacacaaa	8	12	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:11313296C>T	uc002mqs.3	-	42	5366	c.5325G>A	c.(5323-5325)TCG>TCA	p.S1775S	DOCK6_uc002mqr.3_Silent_p.S175S|DOCK6_uc010xlq.1_Silent_p.S1114S	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1775	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GCTTCGTGATCGATGGCTCCT	0.632													0	0	0	0.00278	0	19	251										T	11313296	C	T	11313296	2	4	123	1	0	0	0	0	0	0	0	1	4691	871	31	1		1	DOCK6	19	11313296	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	8579827	11313296	47815687	180	36952										
RGL3	57139	broad.mit.edu	37	chr19	11527337	11527337	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	taccgctgtcttcttgatctCtaccctgggaagaggccccc	9	15	3	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:11527337C>G	uc002mrp.2	-	4	440	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_Splice_Site|RGL3_uc002mro.2_Missense_Mutation_p.E126Q|RGL3_uc002mrq.2_3'UTR	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	126	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						TTCTTGATCTCTACCCTGGGA	0.572													0	0	0	0.001984	0	6	115										G	11527337	C	G	11527337	3	3	123	1	0	0	0	0	1	0	0	0	13278	922	32	1	1838	1	RGL3	19	11527337	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	214041	11527337	47601646	181	36953										
ANKLE1	126549	broad.mit.edu	37	chr19	17394183	17394183	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttgaaactgtggacaaacatGggagctcggcgtcccctcca	11	12	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:17394183G>T	uc002nga.2	+	5	886	c.610G>T	c.(610-612)GGG>TGG	p.G204W	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Missense_Mutation_p.G226W|ANKLE1_uc010xpn.1_Missense_Mutation_p.G258W|ANKLE1_uc002nfy.2_Missense_Mutation_p.G193W|ANKLE1_uc002nfz.2_5'UTR	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	204						nuclear envelope					0						GGACAAACATGGGAGCTCGGC	0.607													1	0	2.4624e-09	0.008871	2.6676e-09	20	130										T	17394183	G	T	17394183	3	4	123	1	0	0	0	0	1	0	0	0	632	1348	47	4	628	4	ANKLE1	19	17394183	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	5866846	17394183	41734800	182	36954										
ANKLE1	126549	broad.mit.edu	37	chr19	17394264	17394264	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cggttgaggtctctggagctGaggacccagcctcggacact	14	12	1	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:17394264G>C	uc002nga.2	+	5	967	c.691G>C	c.(691-693)GAG>CAG	p.E231Q	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Missense_Mutation_p.E253Q|ANKLE1_uc010xpn.1_Missense_Mutation_p.E285Q|ANKLE1_uc002nfy.2_Missense_Mutation_p.E220Q|ANKLE1_uc002nfz.2_5'UTR	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	231						nuclear envelope					0						CTCTGGAGCTGAGGACCCAGC	0.607													0	0	0	0.003163	0	14	98										C	17394264	G	C	17394264	3	2	123	1	0	0	0	0	1	0	0	0	632	1291	45	1	709	1	ANKLE1	19	17394264	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	81	17394264	41734719	183	36955										
ZNF43	7594	broad.mit.edu	37	chr19	21991453	21991453	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aggtttgagaactggttaaaGgctttgccacatacttcaca	9	8	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:21991453G>C	uc002nqj.2	-	4	1516	c.1386C>G	c.(1384-1386)GCC>GCG	p.A462A	ZNF43_uc010ecv.2_Silent_p.A456A|ZNF43_uc002nql.2_Silent_p.A456A|ZNF43_uc002nqm.2_Silent_p.A456A|ZNF43_uc002nqk.2_Silent_p.A392A	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	462	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		ACTGGTTAAAGGCTTTGCCAC	0.398													0	0	0	0.004482	0	9	81										C	21991453	G	C	21991453	2	2	123	1	0	0	0	0	0	0	0	1	17900	987	35	4		4	ZNF43	19	21991453	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	4597189	21991453	37137530	184	36956										
FBXO27	126433	broad.mit.edu	37	chr19	39516075	39516075	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gacagacggactcgcacgatCacactggagttggtcacacg	12	12	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:39516075C>T	uc002okh.2	-	6	910	c.828G>A	c.(826-828)GTG>GTA	p.V276V		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	276	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTCGCACGATCACACTGGAGT	0.587													0	0	0	0.006214	0	8	143										T	39516075	C	T	39516075	2	4	123	1	0	0	0	0	0	0	0	1	5737	813	29	1		1	FBXO27	19	39516075	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	17524622	39516075	19612908	185	36957										
ITPKC	80271	broad.mit.edu	37	chr19	41239168	41239168	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	accctggggcccctacccctGaggagcatgcccagggtgca	13	16	0	1	rs144541337		TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:41239168G>A	uc002oot.2	+	4	1606	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K		NM_025194	NP_079470	Q96DU7	IP3KC_HUMAN	inositol 1,4,5-trisphosphate 3-kinase C	525						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CCCTACCCCTGAGGAGCATGC	0.612													0	0	0	0.00308	0	8	71										A	41239168	G	A	41239168	3	1	123	1	0	0	0	0	1	0	0	0	7919	1291	45	1	1587	1	ITPKC	19	41239168	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1723093	41239168	17889815	186	36958										
ZNF227	7770	broad.mit.edu	37	chr19	44740795	44740795	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ttcgagtccacctgggtgttCacaccagggaaaaactcttt	9	11	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:44740795C>A	uc002oyu.2	+	6	2417	c.2212C>A	c.(2212-2214)CAC>AAC	p.H738N	ZNF227_uc010xwu.1_Missense_Mutation_p.H687N|ZNF227_uc002oyv.2_Missense_Mutation_p.H738N|ZNF227_uc010xwv.1_Missense_Mutation_p.H687N|ZNF227_uc010xww.1_Missense_Mutation_p.H659N|ZNF227_uc002oyw.2_Missense_Mutation_p.H710N|ZNF227_uc010ejh.2_Missense_Mutation_p.H731N|ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_3'UTR	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	738	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				CCTGGGTGTTCACACCAGGGA	0.498													1	0	1.15088e-07	0.004007	1.23697e-07	15	146										A	44740795	C	A	44740795	3	1	123	1	0	0	0	0	1	0	0	0	17778	826	29	3	2226	3	ZNF227	19	44740795	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	3501627	44740795	14388188	187	36959										
DMPK	1760	broad.mit.edu	37	chr19	46278206	46278206	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gccgtccagggcagtgcttaCctgagggccatgcaggagta	15	11	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:46278206C>G	uc002pdd.1	-	8	1806	c.1262_splice	c.e8+1	p.R421_splice	DMPK_uc010xxs.1_Splice_Site_p.R322_splice|DMPK_uc002pde.1_Splice_Site_p.R416_splice|DMPK_uc002pdf.1_Splice_Site_p.R411_splice|DMPK_uc002pdg.1_Splice_Site_p.R406_splice|DMPK_uc002pdh.1_Splice_Site_p.R406_splice|DMPK_uc002pdi.1_Splice_Site_p.R437_splice|DMPK_uc010xxt.1_Splice_Site_p.R406_splice	NM_001081563	NP_001075032	Q09013	DMPK_HUMAN	myotonic dystrophy protein kinase isoform 1						regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)	3		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		GCAGTGCTTACCTGAGGGCCA	0.612													0	0	0	0.009096	0	4	56										G	46278206	C	G	46278206	5	3	123	1	0	0	0	0	0	0	1	0	4584	521	18	4	691	4	DMPK	19	46278206	Splice_Site	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	1537411	46278206	12850777	188	36960										
FOXA3	3171	broad.mit.edu	37	chr19	46375619	46375619	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	cctggcacacgccaagccacCgtattcctatatctcactca	5	17	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:46375619C>T	uc002pdr.2	+	2	553	c.356C>T	c.(355-357)CCG>CTG	p.P119L		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	119	Fork-head.				brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		GCCAAGCCACCGTATTCCTAT	0.627													0	0	0	0.003163	0	15	127										T	46375619	C	T	46375619	3	4	123	1	0	0	0	0	1	0	0	0	5991	652	23	2	362	2	FOXA3	19	46375619	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	97413	46375619	12753364	189	36961										
C19orf48	84798	broad.mit.edu	37	chr19	51301447	51301447	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgagagccaggcccaggtctCacggtggcgtatggacagct	15	11	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:51301447C>T	uc002ptf.2	-	5	1181	c.259G>A	c.(259-261)GAG>AAG	p.E87K	C19orf48_uc002pte.2_RNA|C19orf48_uc002ptg.2_Missense_Mutation_p.E87K	NM_199249	NP_954857	Q6RUI8	CS048_HUMAN	multidrug resistance-related protein	87										ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00531)|GBM - Glioblastoma multiforme(134;0.0145)		GCCCAGGTCTCACGGTGGCGT	0.642													0	0	0	0.003163	0	16	115										T	51301447	C	T	51301447	3	4	123	1	0	0	0	0	1	0	0	0	1931	835	29	1	98	1	C19orf48	19	51301447	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	4925828	51301447	7827536	190	36962										
ZNF841	284371	broad.mit.edu	37	chr19	52570184	52570184	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgccacatacatcacattgGtatggtttccctcttgtatg	7	11	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:52570184G>C	uc002pyl.1	-	5	1155	c.603C>G	c.(601-603)TAC>TAG	p.Y201*	ZNF841_uc010ydh.1_Nonsense_Mutation_p.Y317*|ZNF841_uc010epk.1_Nonsense_Mutation_p.Y201*	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	201	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATCACATTGGTATGGTTTCC	0.418													0	0	0	0.001168	0	6	44										C	52570184	G	C	52570184	4	2	123	1	0	0	0	0	0	1	0	0	18186	1256	44	4	1827	4	ZNF841	19	52570184	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1268737	52570184	6558799	191	36963										
NLRP5	126206	broad.mit.edu	37	chr19	56539147	56539147	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctcacccctcgaggcgtggtCcggcgctgtctcaatctgga	12	15	3	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:56539147C>T	uc002qmj.2	+	7	1548	c.1548C>T	c.(1546-1548)GTC>GTT	p.V516V	NLRP5_uc002qmi.2_Silent_p.V497V	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	516	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GAGGCGTGGTCCGGCGCTGTC	0.592													0	0	0	0.00308	0	8	29										T	56539147	C	T	56539147	2	4	123	1	0	0	0	0	0	0	0	1	10480	842	30	1		1	NLRP5	19	56539147	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	3968963	56539147	2589836	192	36964										
ZNF132	7691	broad.mit.edu	37	chr19	58946488	58946488	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agttagctttcttggtggaaGgatctgcattagggatcctg	13	6	2	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr19:58946488G>A	uc002qst.3	-	3	724	c.323C>T	c.(322-324)CCT>CTT	p.P108L		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	108	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		CTTGGTGGAAGGATCTGCATT	0.498													0	0	0	0.008361	0	27	210										A	58946488	G	A	58946488	3	1	123	1	0	0	0	0	1	0	0	0	17719	1000	35	2	1801	2	ZNF132	19	58946488	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	2407341	58946488	182495	193	36965										
PROCR	10544	broad.mit.edu	37	chr20	33762599	33762599	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tcgctggggggacacctaacGcacgtgctggaaggcccaga	15	12	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr20:33762599G>A	uc002xbt.2	+	2	349	c.165G>A	c.(163-165)ACG>ACA	p.T55T	EDEM2_uc010zuv.1_Intron|PROCR_uc010zuw.1_Silent_p.T92T	NM_006404	NP_006395	Q9UNN8	EPCR_HUMAN	endothelial protein C receptor precursor	55	Extracellular (Potential).				antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity				0			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	GACACCTAACGCACGTGCTGG	0.627													0	0	0	0.001984	0	7	110										A	33762599	G	A	33762599	2	1	123	1	0	0	0	0	0	0	0	1	12547	1074	38	2		2	PROCR	20	33762599	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		33762599	29262921	194	36966										
RALGAPB	57148	broad.mit.edu	37	chr20	37153561	37153561	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgtggttccttactttatttCagctcttgaaaccattttgc	6	9	2	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr20:37153561C>A	uc002xiw.2	+	11	2017	c.1760C>A	c.(1759-1761)TCA>TAA	p.S587*	RALGAPB_uc010zvz.1_3'UTR|RALGAPB_uc002xix.2_Nonsense_Mutation_p.S587*|RALGAPB_uc002xiy.1_Nonsense_Mutation_p.S587*|RALGAPB_uc002xiz.2_Nonsense_Mutation_p.S365*|RALGAPB_uc002xja.1_Nonsense_Mutation_p.S314*	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	587					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TACTTTATTTCAGCTCTTGAA	0.433													1	0	3.8128e-34	0.00361	4.35521e-34	55	275										A	37153561	C	A	37153561	4	1	123	1	0	0	0	0	0	1	0	0	13015	838	29	3	1798	3	RALGAPB	20	37153561	Nonsense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	3390962	37153561	25871959	195	36967										
CABLES2	81928	broad.mit.edu	37	chr20	60966489	60966494	+	In_Frame_Del	DEL	CTCCGC	CTCCGC	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ggctgcactcctccgacaggCtccgcatctcccgctttaag							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr20:60966489_60966494delCTCCGC	uc002ycv.2	-	9	1114_1119	c.1107_1112delGCGGAG	c.(1105-1113)ATGCGGAGC>ATC	p.369_371MRS>I		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	369_371					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			CTCCGACAGGCTCCGCATCTCCCGCT	0.636																		86	231	---	---								-	60966494	CTCCGC	-	60966489	7	5	123	1	0	1	0	1	0	0	0	0	2530	797	28	0	332	0	CABLES2	20	60966489	In_Frame_Del	DEL	CTCCGC	TCGA-GV-A40E-01A-12D-A23M-08	23812928	60966489	2059031	196	36968										
SLC37A1	54020	broad.mit.edu	37	chr21	43938572	43938572	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agtggcgacgtaaatggctcGactccccgctggcattcgct	12	13	0	0			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr21:43938572G>A	uc002zbi.2	+	3	420	c.8G>A	c.(7-9)CGA>CAA	p.R3Q	SLC37A1_uc002zbh.1_RNA|SLC37A1_uc002zbj.2_Missense_Mutation_p.R3Q	NM_018964	NP_061837	P57057	GLPT_HUMAN	solute carrier family 37 member 1	3					carbohydrate transport|transmembrane transport	integral to membrane					0						TAAATGGCTCGACTCCCCGCT	0.547													0	0	0	0.002836	0	30	80										A	43938572	G	A	43938572	3	1	123	1	0	0	0	0	1	0	0	0	14597	1058	37	1	10	1	SLC37A1	21	43938572	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		43938572	4191323	197	36969										
PDE9A	5152	broad.mit.edu	37	chr21	44174150	44174150	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ctgcggaagccgacctttgaCgtctggctttgggagcccaa	13	12	1	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr21:44174150C>T	uc002zbm.2	+	10	849	c.786C>T	c.(784-786)GAC>GAT	p.D262D	PDE9A_uc002zbn.2_Silent_p.D135D|PDE9A_uc002zbo.2_Silent_p.D209D|PDE9A_uc002zbp.2_Silent_p.D55D|PDE9A_uc002zbq.2_Silent_p.D160D|PDE9A_uc002zbs.2_Silent_p.D55D|PDE9A_uc002zbr.2_Silent_p.D55D|PDE9A_uc002zbt.2_Silent_p.D134D|PDE9A_uc002zbu.2_Silent_p.D128D|PDE9A_uc002zbv.2_Silent_p.D102D|PDE9A_uc002zbw.2_Silent_p.D45D|PDE9A_uc002zbx.2_Silent_p.D202D|PDE9A_uc002zby.2_Silent_p.D45D|PDE9A_uc002zbz.2_Silent_p.D154D|PDE9A_uc002zca.2_Silent_p.D221D|PDE9A_uc002zcb.2_Silent_p.D236D|PDE9A_uc002zcc.2_Silent_p.D161D|PDE9A_uc002zcd.2_Silent_p.D176D|PDE9A_uc002zce.2_Silent_p.D195D|PDE9A_uc002zcf.2_Silent_p.D55D|PDE9A_uc002zcg.2_Silent_p.D55D|PDE9A_uc002zch.2_Silent_p.D45D|PDE9A_uc010gpf.1_Silent_p.D55D	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	262					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						CGACCTTTGACGTCTGGCTTT	0.627													0	0	0	0.004482	0	7	56										T	44174150	C	T	44174150	2	4	123	1	0	0	0	0	0	0	0	1	11655	535	19	2		2	PDE9A	21	44174150	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	235578	44174150	3955745	198	36970										
CLTCL1	8218	broad.mit.edu	37	chr22	19175135	19175135	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ccagttattgcccttgtacaGataggccgcaatgcacctga	9	12	0	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr22:19175135G>T	uc002zpb.2	-	30	4615	c.4540C>A	c.(4540-4542)CTG>ATG	p.L1514M	CLTCL1_uc011agv.1_Intron|CLTCL1_uc011agw.1_Missense_Mutation_p.L1493M|CLTCL1_uc011agt.1_Missense_Mutation_p.L305M|CLTCL1_uc011agu.1_Intron	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1514	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					CCCTTGTACAGATAGGCCGCA	0.542			T	NaN	ALCL								1	0	4.14922e-12	0.004007	4.58598e-12	15	115										T	19175135	G	T	19175135	3	4	123	1	0	0	0	0	1	0	0	0	3567	933	33	3	398	3	CLTCL1	22	19175135	Missense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		19175135	32129431	199	36971										
MCM5	4174	broad.mit.edu	37	chr22	35808507	35808507	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgctttgcctaccaaggccgCagctttgctggggccgtgag	14	12	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr22:35808507C>T	uc003anu.3	+	8	1018	c.924C>T	c.(922-924)CGC>CGT	p.R308R	MCM5_uc010gwr.2_Silent_p.R117R|MCM5_uc003anv.3_Silent_p.R265R|MCM5_uc010gws.1_RNA|MCM5_uc003anw.1_Silent_p.R92R	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	308					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						ACCAAGGCCGCAGCTTTGCTG	0.627													0	0	0	0.007413	0	15	186										T	35808507	C	T	35808507	2	4	123	1	0	0	0	0	0	0	0	1	9390	697	25	2		2	MCM5	22	35808507	Silent	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	16633372	35808507	15496059	200	36972										
SYNGR1	9145	broad.mit.edu	37	chr22	39770522	39770522	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	agatcagcagcgtcaaggacCgcaagaaagccgtcctgtcc	11	13	2	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr22:39770522C>G	uc003axq.3	+	2	363	c.301C>G	c.(301-303)CGC>GGC	p.R101G	SYNGR1_uc003axo.3_Missense_Mutation_p.R101G|SYNGR1_uc003axp.3_Silent_p.T31T|TAB1_uc003axr.2_5'UTR|SYNGR1_uc003axs.3_Missense_Mutation_p.R102G	NM_004711	NP_004702	O43759	SNG1_HUMAN	synaptogyrin 1 isoform 1a	101	MARVEL.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity	cell junction|integral to plasma membrane|melanosome					0	Melanoma(58;0.04)					CGTCAAGGACCGCAAGAAAGC	0.622													0	0	0	0.00245	0	13	174										G	39770522	C	G	39770522	3	3	123	1	0	0	0	0	1	0	0	0	15445	652	23	4	413	4	SYNGR1	22	39770522	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	3962015	39770522	11534044	201	36973										
MKL1	57591	broad.mit.edu	37	chr22	40814492	40814492	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	gtgggaggtgcaacccccttGatgaggctggggccctgagg	18	10	0	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chr22:40814492G>A	uc003ayv.1	-	9	2157	c.1950C>T	c.(1948-1950)ATC>ATT	p.I650I	MKL1_uc003ayw.1_Silent_p.I650I|MKL1_uc010gye.1_Silent_p.I650I|MKL1_uc010gyf.1_Silent_p.I600I	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	650	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CAACCCCCTTGATGAGGCTGG	0.662			T	RBM15	acute megakaryocytic leukemia								0	0	0	0.006214	0	9	142										A	40814492	G	A	40814492	2	1	123	1	0	0	0	0	0	0	0	1	9601	1280	45	1		1	MKL1	22	40814492	Silent	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08	1043970	40814492	10490074	202	36974										
PTCHD1	139411	broad.mit.edu	37	chrX	23411319	23411319	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	tgattgggttttacatatatGagtctatagaatactggaac	9	4	1	3			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chrX:23411319G>T	uc004dal.3	+	3	1692	c.1684G>T	c.(1684-1686)GAG>TAG	p.E562*		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	562					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						TTACATATATGAGTCTATAGA	0.403													1	0	0.000274275	0.004482	0.000282555	9	152										T	23411319	G	T	23411319	4	4	123	1	0	0	0	0	0	1	0	0	12732	1291	45	3	1694	3	PTCHD1	23	23411319	Nonsense_Mutation	SNP	G	TCGA-GV-A40E-01A-12D-A23M-08		23411319	131859241	203	36975										
ATRX	546	broad.mit.edu	37	chrX	76939791	76939791	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	ccattacaatttgaactagtCttctttggagaaaatctgga	7	7	3	2			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chrX:76939791C>G	uc004ecp.3	-	9	1189	c.957G>C	c.(955-957)AAG>AAC	p.K319N	ATRX_uc004ecq.3_Missense_Mutation_p.K281N|ATRX_uc004eco.3_Missense_Mutation_p.K104N|ATRX_uc004ecr.2_Missense_Mutation_p.K280N|ATRX_uc010nlx.1_Missense_Mutation_p.K319N|ATRX_uc010nly.1_Missense_Mutation_p.K264N	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	319					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTGAACTAGTCTTCTTTGGAG	0.333			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.008291	0	11	80										G	76939791	C	G	76939791	3	3	123	1	0	0	0	0	1	0	0	0	1208	912	32	1	6629	1	ATRX	23	76939791	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08	53528472	76939791	78330769	204	36976										
RHOXF2B	727940	broad.mit.edu	37	chrX	119293071	119293071	+	Frame_Shift_Del	DEL	A	A	-													0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	aaaagatggcggcggagaagAaaaagatggcggcggcgccg							TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chrX:119293071delA	uc004esl.3	+	2	420	c.230delA	c.(229-231)GAAfs	p.E77fs		NM_001099685	NP_001093155	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2B	77						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCGGAGAAGAAAAAGATGGC	0.607																		18	48	---	---								-	119293071	A	-	119293071	7	5	123	1	0	1	0	1	0	0	0	0	13349	246	9	0	1119	0	RHOXF2B	23	119293071	Frame_Shift_Del	DEL	A	TCGA-GV-A40E-01A-12D-A23M-08	42353280	119293071	35977489	205	36977										
ZFY	7544	broad.mit.edu	37	chrY	2847298	2847298	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.331707317073171	68	1.3837227844324e-19	3.27498197548666	4.44643962848297	2.25371120107962	0.00537021545591478	0.0193924447019145	47	taaaggtttccgacacccgtCggaactgagaaagcacatgc	10	11	0	1			TCGA-GV-A40E-01A-12D-A23M-08	TCGA-GV-A40E-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41dea334-9fa2-4ba1-8091-a17d80d8e950	90e12daf-9cc0-48ae-a8b6-f59ff2037384	g.chrY:2847298C>T	uc004fqj.2	+	8	1991	c.1670C>T	c.(1669-1671)TCG>TTG	p.S557L	ZFY_uc011nan.1_Missense_Mutation_p.S366L|ZFY_uc010nwe.2_Missense_Mutation_p.S480L	NM_003411	NP_003402	P08048	ZFY_HUMAN	zinc finger protein, Y-linked isoform 1	557	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CGACACCCGTCGGAACTGAGA	0.473													0	0	0	0.001984	0	6	26										T	2847298	C	T	2847298	3	4	123	1	0	0	0	0	1	0	0	0	17659	893	31	1	1696	1	ZFY	24	2847298	Missense_Mutation	SNP	C	TCGA-GV-A40E-01A-12D-A23M-08		2847298	56526268	206	36978										
CALML6	163688	broad.mit.edu	37	chr1	1848429	1848429	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtaggtacgtgctaatgaacGcaggggagcccctcaacgag	14	10	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:1848429G>T	uc001aih.1	+	5	869	c.415G>T	c.(415-417)GCA>TCA	p.A139S		NM_138705	NP_619650	Q8TD86	CALL6_HUMAN	calmodulin-like 6	139	EF-hand 3.					cytoplasm|nucleus	calcium ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GCTAATGAACGCAGGGGAGCC	0.667													1	0	8.34094e-07	0.049695	8.73136e-07	20	43										T	1848429	G	T	1848429	3	4	124	1	0	0	0	0	1	0	0	0	2590	1087	38	4	433	4	CALML6	1	1848429	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		1848429	247402192	1	36979										
ACOT7	11332	broad.mit.edu	37	chr1	6445578	6445578	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagtaatgcaggctccacagGgtgggagatcagccctgggc	15	11	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:6445578G>C	uc001ams.2	-	1	306	c.149C>G	c.(148-150)CCC>CGC	p.P50R	ACOT7_uc010nzq.1_Intron|ACOT7_uc001amt.2_Intron|ACOT7_uc001amu.2_Intron|ACOT7_uc001amv.2_Intron	NM_181864	NP_863654	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHb	50						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		GGCTCCACAGGGTGGGAGATC	0.652													0	0	0	0.048971	0	90	154										C	6445578	G	C	6445578	3	2	124	1	0	0	0	0	1	0	0	0	155	1232	43	4	1140	4	ACOT7	1	6445578	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	4597149	6445578	242805043	2	36980										
GRIK3	2899	broad.mit.edu	37	chr1	37319237	37319237	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttctccaggccatcctctttCaggctgatgatgtccagatc	8	13	3	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:37319237C>A	uc001caz.2	-	8	1326	c.1191G>T	c.(1189-1191)CTG>CTT	p.L397L	GRIK3_uc001cba.1_Silent_p.L397L	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	397	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CATCCTCTTTCAGGCTGATGA	0.542													1	0	1.42536e-11	0.099896	1.53788e-11	28	41										A	37319237	C	A	37319237	2	1	124	1	0	0	0	0	0	0	0	1	6775	813	29	3		3	GRIK3	1	37319237	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	30873659	37319237	211931384	3	36981										
LRRC7	57554	broad.mit.edu	37	chr1	70488833	70488833	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tctcctgccaagccccctggGaaaggggccagcgtgggatt	14	13	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:70488833G>A	uc001dep.2	+	15	1486	c.1456G>A	c.(1456-1458)GAA>AAA	p.E486K	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	486						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AGCCCCCTGGGAAAGGGGCCA	0.517													0	0	0	0.038395	0	18	71										A	70488833	G	A	70488833	3	1	124	1	0	0	0	0	1	0	0	0	9020	1175	41	1	1514	1	LRRC7	1	70488833	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	33169596	70488833	178761788	4	36982										
LRRC40	55631	broad.mit.edu	37	chr1	70616831	70616831	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctattaaaggaaagattgatCgtttgcagtcttaccagtga	9	6	1	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:70616831C>T	uc001der.1	-	13	1549	c.1497G>A	c.(1495-1497)ACG>ACA	p.T499T		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	499	LRR 17.									ovary(1)	1						AAAGATTGATCGTTTGCAGTC	0.294													0	0	0	0.038147	0	6	22										T	70616831	C	T	70616831	2	4	124	1	0	0	0	0	0	0	0	1	8998	871	31	1		1	LRRC40	1	70616831	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	127998	70616831	178633790	5	36983										
KCNA10	3744	broad.mit.edu	37	chr1	111061072	111061072	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcatccttttttcccggtctCccaggagagtctctgggaac	10	13	2	1	rs141128096		TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:111061072C>T	uc001dzt.1	-	1	726	c.338G>A	c.(337-339)GGA>GAA	p.G113E		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	113						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		TTCCCGGTCTCCCAGGAGAGT	0.458													0	0	0	0.055883	0	21	44										T	111061072	C	T	111061072	3	4	124	1	0	0	0	0	1	0	0	0	8002	855	30	1	1201	1	KCNA10	1	111061072	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	40444241	111061072	138189549	6	36984										
SEC22B	9554	broad.mit.edu	37	chr1	145103968	145103968	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aactctttcgaaagttgaatGaacagtcccctaccagatgt	7	10	1	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:145103968G>A	uc001eml.1	+	4	276	c.136G>A	c.(136-138)GAA>AAA	p.E46K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	46	Longin.|Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						AAAGTTGAATGAACAGTCCCC	0.383													0	0	0	0.0333	0	16	33										A	145103968	G	A	145103968	3	1	124	1	0	0	0	0	1	0	0	0	13989	1291	45	1	142	1	SEC22B	1	145103968	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	34042896	145103968	104146653	7	36985										
TXNIP	10628	broad.mit.edu	37	chr1	145440061	145440064	+	Frame_Shift_Del	DEL	AAAG	AAAG	-													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cctgtgtctgctaaaaaagaAaagaaagtttcctgcatgtt							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			AAAG	-	AAAG	AAAG		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:145440061_145440064delAAAG	uc001enn.3	+	4	836_839	c.495_498delAAAG	c.(493-498)GAAAAGfs	p.E165fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Del_p.E110fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	165_166					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding	p.K166R(1)		ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTAAAAAAGAAAAGAAAGTTTCCT	0.417																		123	642	---	---								-	145440064	AAAG	-	145440061	7	5	124	1	0	1	0	1	0	0	0	0	16800	11	1	0	509	0	TXNIP	1	145440061	Frame_Shift_Del	DEL	AAAG	TCGA-GV-A40G-01A-11D-A23M-08	336093	145440061	103810560	8	36986										
FLG	2312	broad.mit.edu	37	chr1	152283577	152283577	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tggatccctggtgcctgcttGtcctggaccccgatgattgt	12	12	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:152283577G>C	uc001ezu.1	-	3	3821	c.3785C>G	c.(3784-3786)ACA>AGA	p.T1262R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1262	Ser-rich.|Filaggrin 7.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCCTGCTTGTCCTGGACCC	0.532									Ichthyosis				0	0	0	0.048971	0	87	771										C	152283577	G	C	152283577	3	2	124	1	0	0	0	0	1	0	0	0	5922	1377	48	4	8404	4	FLG	1	152283577	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	6843516	152283577	96967044	9	36987										
FLG2	388698	broad.mit.edu	37	chr1	152324511	152324511	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccatgagtagtttggtgtctCttgtgaactgtggattctga	12	6	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:152324511C>G	uc001ezw.3	-	3	5824	c.5751G>C	c.(5749-5751)AAG>AAC	p.K1917N	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1917							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTGGTGTCTCTTGTGAACTG	0.502													0	0	0	0.048971	0	70	546										G	152324511	C	G	152324511	3	3	124	1	0	0	0	0	1	0	0	0	5923	912	32	1	1428	1	FLG2	1	152324511	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	40934	152324511	96926110	10	36988										
MUC1	4582	broad.mit.edu	37	chr1	155161799	155161799	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gacatcgtgggctggcggggTggtggagcccagggctggcc	21	10	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:155161799T>G	uc010pft.1	-	2	400	c.334A>C	c.(334-336)ACC>CCC	p.T112P	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_5'Flank|MUC1_uc001fhz.2_5'Flank|MUC1_uc010pfb.1_Intron|MUC1_uc010pfc.1_Intron|MUC1_uc009wph.2_Intron|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Intron|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Intron|MUC1_uc010pfi.1_Intron|MUC1_uc010pfj.1_Intron|MUC1_uc010pfk.1_Intron|MUC1_uc010pfl.1_Intron|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Intron|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Intron|MUC1_uc009wps.2_Intron|MUC1_uc009wpt.2_Intron|MUC1_uc001fic.2_Intron|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Intron|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Intron|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Intron|MUC1_uc001fiq.2_Intron|MUC1_uc009wpz.2_Intron|MUC1_uc010pfn.1_Intron|MUC1_uc009wqa.2_Intron|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Intron|MUC1_uc009wqc.2_Intron|MUC1_uc009wqd.2_Intron|MUC1_uc009wqb.2_Intron|MUC1_uc010pfq.1_Intron|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Intron|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Intron|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_Intron|MUC1_uc001fik.2_Intron|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Intron|MUC1_uc001fis.1_Intron|uc009wqh.2_5'Flank|MUC1_uc001fiv.1_Missense_Mutation_p.T121P|MUC1_uc001fiw.1_Missense_Mutation_p.T112P			P15941	MUC1_HUMAN	SubName: Full=MUC1 isoform M13;	112	Extracellular (Potential).|3.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTGGCGGGGTGGTGGAGCCC	0.711			T	IGH@	B-NHL								0	0	0	0.099896	0	16	62										G	155161799	T	G	155161799	3	3	124	1	0	0	0	0	1	0	0	0	9970	1711	59	5		5	MUC1	1	155161799	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	2837288	155161799	94088822	11	36989										
IQGAP3	128239	broad.mit.edu	37	chr1	156500962	156500962	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggctactcacttgctctctgGaagccgagagggacaggatc	13	11	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:156500962G>A	uc001fpf.2	-	33	4256	c.4181C>T	c.(4180-4182)TCC>TTC	p.S1394F		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1394					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTGCTCTCTGGAAGCCGAGAG	0.582													0	0	0	0.048971	0	42	267										A	156500962	G	A	156500962	3	1	124	1	0	0	0	0	1	0	0	0	7816	1174	41	1	738	1	IQGAP3	1	156500962	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1339163	156500962	92749659	12	36990										
CD1E	913	broad.mit.edu	37	chr1	158325145	158325145	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atgaatgccccacaaatcttCttaaatatggcatatcaagg	6	9	3	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:158325145C>T	uc001fse.2	+	3	650	c.411C>T	c.(409-411)TTC>TTT	p.F137F	CD1E_uc010pid.1_Silent_p.F135F|CD1E_uc010pie.1_Silent_p.F38F|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Silent_p.F137F|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Silent_p.F137F|CD1E_uc001fry.2_Silent_p.F137F|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Silent_p.F137F|CD1E_uc009wsv.2_Silent_p.F38F|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	137					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					CACAAATCTTCTTAAATATGG	0.463													0	0	0	0.11126	0	43	257										T	158325145	C	T	158325145	2	4	124	1	0	0	0	0	0	0	0	1	2978	912	32	1		1	CD1E	1	158325145	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1824183	158325145	90925476	13	36991										
F5	2153	broad.mit.edu	37	chr1	169505755	169505755	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aagacttacttggataacatCatccacttcagctctgataa	5	10	3	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:169505755C>T	uc001ggg.1	-	14	5105	c.4960G>A	c.(4960-4962)GAT>AAT	p.D1654N		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1654	F5/8 type A 3.|Plastocyanin-like 5.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGGATAACATCATCCACTTCA	0.458													0	0	0	0.021553	0	5	26										T	169505755	C	T	169505755	3	4	124	1	0	0	0	0	1	0	0	0	5348	826	29	1	1762	1	F5	1	169505755	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	11180610	169505755	79744866	14	36992										
FAM5C	339479	broad.mit.edu	37	chr1	190067739	190067739	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccgaagggattgacataaacAgccaacactggctccaaggt	10	11	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:190067739A>C	uc001gse.1	-	8	1942	c.1710T>G	c.(1708-1710)GCT>GCG	p.A570A	FAM5C_uc010pot.1_Silent_p.A468A	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	570						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGACATAAACAGCCAACACTG	0.453													0	0	0	0.014758	0	5	125										C	190067739	A	C	190067739	2	2	124	1	0	0	0	0	0	0	0	1	5594	175	7	5		5	FAM5C	1	190067739	Silent	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	20561984	190067739	59182882	15	36993										
CD34	947	broad.mit.edu	37	chr1	208072507	208072507	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acagaggtctgtgactggacAgaagagtttgtgtttccata	12	6	1	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:208072507A>G	uc001hgw.1	-	3	585	c.327T>C	c.(325-327)TCT>TCC	p.S109S	CD34_uc001hgx.1_Silent_p.S109S|CD34_uc010psj.1_Intron	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	109	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						GTGACTGGACAGAAGAGTTTG	0.468													0	0	0	0.048971	0	130	64										G	208072507	A	G	208072507	2	3	124	1	0	0	0	0	0	0	0	1	3006	175	7	5		5	CD34	1	208072507	Silent	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	18004768	208072507	41178114	16	36994										
DISP1	84976	broad.mit.edu	37	chr1	223177436	223177436	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gctatcatggagctggaaagGagtacagggtaccatttgga	14	6	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:223177436G>A	uc001hnu.1	+	8	2844	c.2697G>A	c.(2695-2697)AGG>AGA	p.R899R		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	899					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AGCTGGAAAGGAGTACAGGGT	0.493													0	0	0	0.108266	0	27	45										A	223177436	G	A	223177436	2	1	124	1	0	0	0	0	0	0	0	1	4539	1165	41	1		1	DISP1	1	223177436	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	15104929	223177436	26073185	17	36995										
SUSD4	55061	broad.mit.edu	37	chr1	223465953	223465953	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggggtcctgaagccattctcGggaatgccggggtcagcaca	15	11	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:223465953G>A	uc001hnx.2	-	2	823	c.189C>T	c.(187-189)CCC>CCT	p.P63P	SUSD4_uc001hny.3_Silent_p.P63P|SUSD4_uc010puw.1_5'UTR|SUSD4_uc001hnz.2_Silent_p.P63P|SUSD4_uc010pux.1_Intron	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	63	Sushi 1.|Extracellular (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		AGCCATTCTCGGGAATGCCGG	0.517													0	0	0	0.048971	0	47	32										A	223465953	G	A	223465953	2	1	124	1	0	0	0	0	0	0	0	1	15407	1103	39	2		2	SUSD4	1	223465953	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	288517	223465953	25784668	18	36996										
RGS7	6000	broad.mit.edu	37	chr1	241099994	241099994	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagccattaatgttcccaaaTggagcgcctccactgtttta	7	12	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:241099994T>C	uc001hyv.2	-	5	569	c.239A>G	c.(238-240)CAT>CGT	p.H80R	RGS7_uc010pyh.1_Missense_Mutation_p.H54R|RGS7_uc010pyj.1_5'UTR|RGS7_uc001hyu.2_Missense_Mutation_p.H80R|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Missense_Mutation_p.H80R	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	80	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TGTTCCCAAATGGAGCGCCTC	0.383													0	0	0	0.083992	0	24	49										C	241099994	T	C	241099994	3	2	124	1	0	0	0	0	1	0	0	0	13310	1464	51	5	1280	5	RGS7	1	241099994	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	17634041	241099994	8150627	19	36997										
OR2M2	391194	broad.mit.edu	37	chr1	248343646	248343646	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcttttggctgttatggcttAtgaccgctatattgctattt	8	7	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr1:248343646A>G	uc010pzf.1	+	1	359	c.359A>G	c.(358-360)TAT>TGT	p.Y120C		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	120	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTTATGGCTTATGACCGCTAT	0.413													0	0	0	0.048971	0	53	215										G	248343646	A	G	248343646	3	3	124	1	0	0	0	0	1	0	0	0	11010	449	16	5	361	5	OR2M2	1	248343646	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	7243652	248343646	906975	20	36998										
MYT1L	23040	broad.mit.edu	37	chr2	1983318	1983319	+	Nonsense_Mutation	DNP	CC	CC	AT													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagctcttgtatggctggttCcacgggaactgcagagagat							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:1983318_1983319CC>AT	uc002qxe.2	-	7	890_891	c.63_64GG>AT	c.(61-66)GTGGAA>GTATAA	p.E22*	MYT1L_uc002qxd.2_Nonsense_Mutation_p.E22*	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	22					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		ATGGCTGGTTCCACGGGAACTG	0.45													0	0	0	0.004672	0	18	43										AT	1983319	CC	AT	1983318	4	1	124	1	0	0	0	0	0	1	0	0	10107	864	30	3	3566	3	MYT1L	2	1983318	Nonsense_Mutation	DNP	CC	TCGA-GV-A40G-01A-11D-A23M-08		1983318	241216055	21	36999										
CD207	50489	broad.mit.edu	37	chr2	71060168	71060168	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cttccagccttgagaaaccaCctgtagaatatcatctagag	7	11	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:71060168C>T	uc002shg.2	-	4	627	c.580G>A	c.(580-582)GTG>ATG	p.V194M		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	194	Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						TGAGAAACCACCTGTAGAATA	0.453													0	0	0	0.099896	0	27	18										T	71060168	C	T	71060168	3	4	124	1	0	0	0	0	1	0	0	0	2983	507	18	2	418	2	CD207	2	71060168	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	69076850	71060168	172139205	22	37000										
DCTN1	1639	broad.mit.edu	37	chr2	74598210	74598210	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gattttgtgtttctccagctCttttagctttgctttgtctt	7	8	3	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:74598210C>T	uc002skx.2	-	9	1050	c.739G>A	c.(739-741)GAG>AAG	p.E247K	DCTN1_uc002skv.2_Missense_Mutation_p.E113K|DCTN1_uc002sku.2_Missense_Mutation_p.E113K|DCTN1_uc002skw.1_Missense_Mutation_p.E223K|DCTN1_uc010ffd.2_Missense_Mutation_p.E227K|DCTN1_uc002sky.2_Missense_Mutation_p.E210K	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	247	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						TTCTCCAGCTCTTTTAGCTTT	0.562													0	0	0	0.105934	0	14	397										T	74598210	C	T	74598210	3	4	124	1	0	0	0	0	1	0	0	0	4306	922	32	1	3193	1	DCTN1	2	74598210	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	3538042	74598210	168601163	23	37001										
AUP1	550	broad.mit.edu	37	chr2	74756363	74756363	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccggagtccggagtcctcctGccgggccacgagccctagca	13	17	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:74756363G>A	uc010yry.1	-	3	453	c.235C>T	c.(235-237)CAG>TAG	p.Q79*	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Nonsense_Mutation_p.Q79*|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_5'UTR|AUP1_uc010yrx.1_Nonsense_Mutation_p.Q136*|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ58836, highly similar to Ancient ubiquitous protein 1;	79	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						GAGTCCTCCTGCCGGGCCACG	0.587													0	0	0	0.038147	0	8	26										A	74756363	G	A	74756363	4	1	124	1	0	0	0	0	0	1	0	0	1220	1328	46	2	1037	2	AUP1	2	74756363	Nonsense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	158153	74756363	168443010	24	37002										
HTRA2	27429	broad.mit.edu	37	chr2	74757942	74757942	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atcgcaacgctgaggattcaGactaaggtgggggctggggt	17	7	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:74757942G>C	uc002smi.1	+	2	1307	c.705G>C	c.(703-705)CAG>CAC	p.Q235H	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.Q235H|HTRA2_uc002smk.1_Missense_Mutation_p.Q235H|HTRA2_uc002sml.1_Missense_Mutation_p.Q235H|HTRA2_uc002smm.1_5'UTR|HTRA2_uc002smn.1_5'UTR|HTRA2_uc010ffl.2_5'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	235	Serine protease.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						TGAGGATTCAGACTAAGGTGG	0.572													0	0	0	0.092188	0	43	123										C	74757942	G	C	74757942	3	2	124	1	0	0	0	0	1	0	0	0	7454	933	33	1	711	1	HTRA2	2	74757942	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1579	74757942	168441431	25	37003										
FER1L5	90342	broad.mit.edu	37	chr2	97368447	97368447	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctttaccatggactacctggCggcggagcgcacgtgtgtcc	13	13	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:97368447C>T	uc010fia.2	+	47	5474	c.5474C>T	c.(5473-5475)GCG>GTG	p.A1825V	FER1L5_uc002sws.3_Missense_Mutation_p.A534V|FER1L5_uc002swt.3_Missense_Mutation_p.A534V|FER1L5_uc010yus.1_Missense_Mutation_p.A533V	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1825	C2 6.					integral to membrane				ovary(1)	1						GACTACCTGGCGGCGGAGCGC	0.612													0	0	0	0.038147	0	8	23										T	97368447	C	T	97368447	3	4	124	1	0	0	0	0	1	0	0	0	5814	768	27	2	5660	2	FER1L5	2	97368447	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	22610505	97368447	145830926	26	37004										
C2orf55	343990	broad.mit.edu	37	chr2	99463239	99463239	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgcagcctcccgaagcttaaTgtccatcacccttgtggaaa	8	13	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:99463239T>C	uc002szf.1	-	2	319	c.25A>G	c.(25-27)ATT>GTT	p.I9V		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	9											0						CGAAGCTTAATGTCCATCACC	0.502													0	0	0	0.048971	0	57	65										C	99463239	T	C	99463239	3	2	124	1	0	0	0	0	1	0	0	0	2176	1464	51	5	2899	5	C2orf55	2	99463239	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	2094792	99463239	143736134	27	37005										
IL1F10	84639	broad.mit.edu	37	chr2	113832410	113832410	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtgtggagacagaagaggggCcttccctacagctggaggtg	17	8	0	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:113832410C>A	uc002tiu.2	+	4	304	c.229C>A	c.(229-231)CCT>ACT	p.P77T	IL1F10_uc002tiv.2_Missense_Mutation_p.P77T|IL1F10_uc002tiw.2_Missense_Mutation_p.P69T	NM_173161	NP_775184	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10	77						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			ovary(1)	1						AGAAGAGGGGCCTTCCCTACA	0.602													1	0	2.27111e-07	0.09319	2.38758e-07	13	41										A	113832410	C	A	113832410	3	1	124	1	0	0	0	0	1	0	0	0	7652	739	26	4	239	4	IL1F10	2	113832410	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	14369171	113832410	129366963	28	37006										
NCKAP5	344148	broad.mit.edu	37	chr2	133542251	133542251	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcaattccctgaggtaaaagCtcagtatgttctgccttggg	11	9	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:133542251C>A	uc002ttp.2	-	14	2507	c.2133G>T	c.(2131-2133)GAG>GAT	p.E711D	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	711							protein binding				0						GAGGTAAAAGCTCAGTATGTT	0.433													1	0	1.16021e-09	0.034045	1.24634e-09	30	111										A	133542251	C	A	133542251	3	1	124	1	0	0	0	0	1	0	0	0	10223	796	28	4	3624	4	NCKAP5	2	133542251	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	19709841	133542251	109657122	29	37007										
GRB14	2888	broad.mit.edu	37	chr2	165350941	165350941	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgaaatcacgaattacttacTggtataatttgaaagtgctt	7	5	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:165350941T>C	uc002ucl.2	-	13	2017	c.1476A>G	c.(1474-1476)CCA>CCG	p.P492P	GRB14_uc010zcv.1_Silent_p.P405P|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	492	SH2.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						AATTACTTACTGGTATAATTT	0.323													0	0	0	0.059317	0	33	38										C	165350941	T	C	165350941	2	2	124	1	0	0	0	0	0	0	0	1	6757	1594	55	5		5	GRB14	2	165350941	Silent	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	31808690	165350941	77848432	30	37008										
SCN9A	6335	broad.mit.edu	37	chr2	167108339	167108339	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcctctgcttcttctccttcTccaggcaaagggttatcaac	7	14	5	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:167108339T>C	uc010fpl.2	-	18	3716	c.3375A>G	c.(3373-3375)GGA>GGG	p.G1125G	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1136						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CTTCTCCTTCTCCAGGCAAAG	0.458													0	0	0	0.09319	0	11	46										C	167108339	T	C	167108339	2	2	124	1	0	0	0	0	0	0	0	1	13925	1538	54	5		5	SCN9A	2	167108339	Silent	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	1757398	167108339	76091034	31	37009										
TTN	7273	broad.mit.edu	37	chr2	179425858	179425858	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagatggctcactaactgagTcagcagcattccttgcaaaa	8	11	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:179425858T>C	uc010zfg.1	-	275	77521	c.77297A>G	c.(77296-77298)GAC>GGC	p.D25766G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D19461G|TTN_uc010zfi.1_Missense_Mutation_p.D19394G|TTN_uc010zfj.1_Missense_Mutation_p.D19269G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26693							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTAACTGAGTCAGCAGCATT	0.383													0	0	0	0.045705	0	31	127										C	179425858	T	C	179425858	3	2	124	1	0	0	0	0	1	0	0	0	16732	1667	58	5	23126	5	TTN	2	179425858	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	12317519	179425858	63773515	32	37010										
TTN	7273	broad.mit.edu	37	chr2	179634499	179634499	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggtgttcatgatgatcagctGatggagttttccctgcacaa	11	8	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:179634499G>A	uc010zfg.1	-	37	9033	c.8809C>T	c.(8809-8811)CAG>TAG	p.Q2937*	TTN_uc010zfh.1_Nonsense_Mutation_p.Q2891*|TTN_uc010zfi.1_Nonsense_Mutation_p.Q2891*|TTN_uc010zfj.1_Nonsense_Mutation_p.Q2891*|TTN_uc002unb.2_Nonsense_Mutation_p.Q2937*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2937							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGATCAGCTGATGGAGTTTT	0.473													0	0	0	0.048971	0	50	182										A	179634499	G	A	179634499	4	1	124	1	0	0	0	0	0	1	0	0	16732	1299	45	1	102483	1	TTN	2	179634499	Nonsense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	208641	179634499	63564874	33	37011										
INO80D	54891	broad.mit.edu	37	chr2	206872144	206872144	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tccggcaactcatcagcactCagctctggcgtggatgggct	12	13	4	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:206872144C>T	uc002vaz.3	-	10	2187	c.1782G>A	c.(1780-1782)CTG>CTA	p.L594L		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	594					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CATCAGCACTCAGCTCTGGCG	0.498													0	0	0	0.058154	0	8	165										T	206872144	C	T	206872144	2	4	124	1	0	0	0	0	0	0	0	1	7749	813	29	1		1	INO80D	2	206872144	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	27237645	206872144	36327229	34	37012										
ZDBF2	57683	broad.mit.edu	37	chr2	207170653	207170653	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gttaccaaccaatcccaaatGattgttaaagaaataagtct	5	8	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:207170653G>A	uc002vbp.2	+	5	1651	c.1401G>A	c.(1399-1401)ATG>ATA	p.M467I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	467							nucleic acid binding|zinc ion binding			ovary(3)	3						AATCCCAAATGATTGTTAAAG	0.323													0	0	0	0.069234	0	11	19										A	207170653	G	A	207170653	3	1	124	1	0	0	0	0	1	0	0	0	17596	1290	45	1	1411	1	ZDBF2	2	207170653	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	298509	207170653	36028720	35	37013										
FASTKD2	22868	broad.mit.edu	37	chr2	207636741	207636741	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aatgcagtaaggtggtcctaGgtaagaggaatttttctttc	11	5	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:207636741G>T	uc002vbu.2	+	5	1524	c.1114G>T	c.(1114-1116)GAT>TAT	p.D372Y	FASTKD2_uc002vbv.2_Missense_Mutation_p.D372Y|FASTKD2_uc002vbx.2_Missense_Mutation_p.D372Y|FASTKD2_uc002vbw.1_Missense_Mutation_p.D372Y	NM_001136193	NP_001129665	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	372					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|skin(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		GGTGGTCCTAGGTAAGAGGAA	0.333													1	0	0.000157383	0.038147	0.000162673	8	141										T	207636741	G	T	207636741	3	4	124	1	0	0	0	0	1	0	0	0	5686	1014	35	4	1128	4	FASTKD2	2	207636741	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	466088	207636741	35562632	36	37014										
CHRND	1144	broad.mit.edu	37	chr2	233391291	233391291	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atccggcacctgtttcaagaGaagggctacaacaaggagct	11	10	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:233391291G>C	uc002vsw.2	+	2	109	c.105G>C	c.(103-105)GAG>GAC	p.E35D	CHRND_uc010zmg.1_Missense_Mutation_p.E35D|CHRND_uc010fyc.2_5'UTR|CHRND_uc010zmh.1_5'UTR	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	35	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		TGTTTCAAGAGAAGGGCTACA	0.632													0	0	0	0.021553	0	6	43										C	233391291	G	C	233391291	3	2	124	1	0	0	0	0	1	0	0	0	3394	933	33	1	111	1	CHRND	2	233391291	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	25754550	233391291	9808082	37	37015										
TRPM8	79054	broad.mit.edu	37	chr2	234878872	234878872	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggaagaaacctgtcgacaaGcacaagaagctgctttggta	11	8	0	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr2:234878872G>A	uc002vvh.2	+	17	2197	c.2157G>A	c.(2155-2157)AAG>AAA	p.K719K	TRPM8_uc010fyj.2_Intron	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	719	Extracellular (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTGTCGACAAGCACAAGAAGC	0.532													0	0	0	0.02938	0	6	95										A	234878872	G	A	234878872	2	1	124	1	0	0	0	0	0	0	0	1	16589	962	34	2		2	TRPM8	2	234878872	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1487581	234878872	8320501	38	37016										
GRM7	2917	broad.mit.edu	37	chr3	6903549	6903549	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggagtgattggggcttcgggGagttcggtctccatcatggt	17	7	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:6903549G>A	uc003bqm.2	+	1	748	c.474G>A	c.(472-474)GGG>GGA	p.G158G	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.G158G|GRM7_uc003bql.2_Silent_p.G158G	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	158	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGGCTTCGGGGAGTTCGGTCT	0.612													0	0	0	0.038395	0	17	82										A	6903549	G	A	6903549	2	1	124	1	0	0	0	0	0	0	0	1	6802	1161	41	1		1	GRM7	3	6903549	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		6903549	191118881	39	37017										
RARB	5915	broad.mit.edu	37	chr3	25637964	25637964	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttcctggatcaatgccacctCtcattcaagaaatgctggag	8	11	3	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:25637964C>G	uc011awl.1	+	8	1291	c.1225C>G	c.(1225-1227)CTC>GTC	p.L409V	RARB_uc003cdi.1_Missense_Mutation_p.L290V|RARB_uc003cdh.2_Missense_Mutation_p.L402V	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	409	Ligand-binding.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AATGCCACCTCTCATTCAAGA	0.433													0	0	0	0.11126	0	41	137										G	25637964	C	G	25637964	3	3	124	1	0	0	0	0	1	0	0	0	13053	913	32	1	1234	1	RARB	3	25637964	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	18734415	25637964	172384466	40	37018										
ZCWPW2	152098	broad.mit.edu	37	chr3	28562491	28562491	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctgtttttttagttgtctgtGagacggaagttttactaaaa	9	4	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:28562491G>A	uc003ceh.2	+	9	961	c.793G>A	c.(793-795)GAG>AAG	p.E265K	ZCWPW2_uc003cei.2_Missense_Mutation_p.E265K|ZCWPW2_uc010hfo.2_Missense_Mutation_p.E70K	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	265							zinc ion binding			ovary(2)	2						AGTTGTCTGTGAGACGGAAGT	0.373													0	0	0	0.080935	0	12	40										A	28562491	G	A	28562491	3	1	124	1	0	0	0	0	1	0	0	0	17595	1291	45	1	819	1	ZCWPW2	3	28562491	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2924527	28562491	169459939	41	37019										
ZNF445	353274	broad.mit.edu	37	chr3	44491019	44491019	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	actcacctgtaggagcagcaActggattccccttaggctga	10	12	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:44491019A>G	uc003cnf.2	-	7	1265	c.917T>C	c.(916-918)GTT>GCT	p.V306A	ZNF445_uc011azv.1_Missense_Mutation_p.V294A|ZNF445_uc011azw.1_Missense_Mutation_p.V306A	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	306					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		AGGAGCAGCAACTGGATTCCC	0.522													0	0	0	0.030593	0	29	41										G	44491019	A	G	44491019	3	3	124	1	0	0	0	0	1	0	0	0	17915	43	2	5	2186	5	ZNF445	3	44491019	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	15928528	44491019	153531411	42	37020										
ZNF660	285349	broad.mit.edu	37	chr3	44636003	44636003	+	Nonsense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cacactggactgaagccctaTacatgcagtgaatgtgggaa	11	9	0	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:44636003T>G	uc003cnl.1	+	3	651	c.318T>G	c.(316-318)TAT>TAG	p.Y106*		NM_173658	NP_775929	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	106	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TGAAGCCCTATACATGCAGTG	0.443													0	0	0	0.009096	0	4	110										G	44636003	T	G	44636003	4	3	124	1	0	0	0	0	0	1	0	0	18067	1413	49	5	320	5	ZNF660	3	44636003	Nonsense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	144984	44636003	153386427	43	37021										
PROS1	5627	broad.mit.edu	37	chr3	93611935	93611935	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagtatcacgccttctgaatCatatgtccggaaatcaaatt	6	10	4	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:93611935C>T	uc003drb.3	-	10	1338	c.997G>A	c.(997-999)GAT>AAT	p.D333N	PROS1_uc010hoo.2_Missense_Mutation_p.D202N|PROS1_uc003dqz.3_Missense_Mutation_p.D202N	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	333	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CCTTCTGAATCATATGTCCGG	0.383													0	0	0	0.014758	0	5	34										T	93611935	C	T	93611935	3	4	124	1	0	0	0	0	1	0	0	0	12558	826	29	1	1057	1	PROS1	3	93611935	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	48975932	93611935	104410495	44	37022										
ZIC1	7545	broad.mit.edu	37	chr3	147128662	147128662	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccatgcacgagctagttacgCacgtcaccgtggagcacgta	11	13	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:147128662C>A	uc003ewe.2	+	1	1482	c.763C>A	c.(763-765)CAC>AAC	p.H255N		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	255	C2H2-type 1; atypical.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GCTAGTTACGCACGTCACCGT	0.557													1	0	1.08241e-25	0.048971	1.23274e-25	67	107										A	147128662	C	A	147128662	3	1	124	1	0	0	0	0	1	0	0	0	17675	710	25	4	765	4	ZIC1	3	147128662	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	53516727	147128662	50893768	45	37023										
SHOX2	6474	broad.mit.edu	37	chr3	157815938	157815938	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgaggcggcggaagccgaatCcgcggccagcgtggcgagcg	19	13	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:157815938C>T	uc003fbr.2	-	5	1013	c.874G>A	c.(874-876)GAT>AAT	p.D292N	SHOX2_uc003fbs.2_Missense_Mutation_p.D316N|SHOX2_uc010hvw.2_Missense_Mutation_p.D280N	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	292					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			GAAGCCGAATCCGCGGCCAGC	0.672													0	0	0	0.048971	0	70	428										T	157815938	C	T	157815938	3	4	124	1	0	0	0	0	1	0	0	0	14289	855	30	1	125	1	SHOX2	3	157815938	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	10687276	157815938	40206492	46	37024										
ATP13A4	84239	broad.mit.edu	37	chr3	193166040	193166040	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggctgagatgagctcttccaAgacaggttttgtctcttcct	10	10	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr3:193166040A>C	uc003ftd.2	-	18	2215	c.2107T>G	c.(2107-2109)TTG>GTG	p.L703V	ATP13A4_uc003fte.1_Missense_Mutation_p.L703V|ATP13A4_uc011bsr.1_Missense_Mutation_p.L174V|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	703	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AGCTCTTCCAAGACAGGTTTT	0.398													0	0	0	0.0333	0	15	72										C	193166040	A	C	193166040	3	2	124	1	0	0	0	0	1	0	0	0	1126	69	3	5	1535	5	ATP13A4	3	193166040	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	35350102	193166040	4856390	47	37025										
GRXCR1	389207	broad.mit.edu	37	chr4	42895368	42895368	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cctctcacagtgggcgagttCtgaaggaagtgtatgaagat	13	7	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:42895368C>T	uc003gwt.2	+	1	85	c.85C>T	c.(85-87)CTG>TTG	p.L29L		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	29					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						TGGGCGAGTTCTGAAGGAAGT	0.522													0	0	0	0.059317	0	37	74										T	42895368	C	T	42895368	2	4	124	1	0	0	0	0	0	0	0	1	6812	912	32	1		1	GRXCR1	4	42895368	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		42895368	148258908	48	37026										
WDFY3	23001	broad.mit.edu	37	chr4	85634393	85634393	+	Splice_Site	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atggcactacagccaaaaacCtgaaaaatttaaaatagcgt	6	8	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:85634393C>T	uc003hpd.2	-	51	8370	c.7962_splice	c.e51-1	p.R2654_splice	WDFY3_uc003hpe.1_Splice_Site_p.R265_splice	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGCCAAAAACCTGAAAAATTT	0.423													0	0	0	0.034045	0	30	99										T	85634393	C	T	85634393	5	4	124	1	0	0	0	0	0	0	1	0	17267	695	24	2	2691	2	WDFY3	4	85634393	Splice_Site	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	42739025	85634393	105519883	49	37027										
FAT4	79633	broad.mit.edu	37	chr4	126370861	126370861	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agtaactcaggtatttgcaaCagatcctgatgagggatcaa	10	7	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:126370861C>G	uc003ifj.3	+	9	8690	c.8690C>G	c.(8689-8691)ACA>AGA	p.T2897R	FAT4_uc011cgp.1_Missense_Mutation_p.T1195R|FAT4_uc003ifi.1_Missense_Mutation_p.T375R	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2897	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTATTTGCAACAGATCCTGAT	0.363													0	0	0	0.014758	0	5	89										G	126370861	C	G	126370861	3	3	124	1	0	0	0	0	1	0	0	0	5692	478	17	4	8724	4	FAT4	4	126370861	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	40736468	126370861	64783415	50	37028										
DCLK2	166614	broad.mit.edu	37	chr4	151168844	151168844	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctgggataacatcacggactCtgccaaggtaccctccaggc	10	14	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:151168844C>T	uc003ilm.3	+	13	1968	c.1868C>T	c.(1867-1869)TCT>TTT	p.S623F	DCLK2_uc003iln.3_Missense_Mutation_p.S622F|DCLK2_uc003ilo.3_Missense_Mutation_p.S640F|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	623	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					ATCACGGACTCTGCCAAGGTA	0.542													0	0	0	0.058154	0	9	14										T	151168844	C	T	151168844	3	4	124	1	0	0	0	0	1	0	0	0	4292	913	32	1	1918	1	DCLK2	4	151168844	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	24797983	151168844	39985432	51	37029										
PRSS48	345062	broad.mit.edu	37	chr4	152203350	152203350	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gctaggatcgattacagtagGtgactcaaggaaacgtgtga	13	6	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:152203350G>A	uc011cif.1	+	3	266	c.266G>A	c.(265-267)GGT>GAT	p.G89D	PRSS48_uc011cig.1_Intron	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	89	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			large_intestine(1)	1						ATTACAGTAGGTGACTCAAGG	0.478													0	0	0	0.105934	0	13	168										A	152203350	G	A	152203350	3	1	124	1	0	0	0	0	1	0	0	0	12630	1261	44	2	276	2	PRSS48	4	152203350	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1034506	152203350	38950926	52	37030										
FSTL5	56884	broad.mit.edu	37	chr4	162954796	162954796	+	Frame_Shift_Del	DEL	T	T	-													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cctttgactcttgaactttcTtgatttttttcctgctggaa							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:162954796delT	uc003iqh.2	-	3	577	c.141delA	c.(139-141)CAAfs	p.Q47fs	FSTL5_uc003iqi.2_Frame_Shift_Del_p.Q46fs|FSTL5_uc010iqv.2_Frame_Shift_Del_p.Q46fs|uc011cji.1_Intron	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	47						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTGAACTTTCTTGATTTTTTT	0.259																		2	4	---	---								-	162954796	T	-	162954796	7	5	124	1	0	1	0	1	0	0	0	0	6080	1606	56	0	2458	0	FSTL5	4	162954796	Frame_Shift_Del	DEL	T	TCGA-GV-A40G-01A-11D-A23M-08	10751446	162954796	28199480	53	37031										
SC4MOL	6307	broad.mit.edu	37	chr4	166254772	166254772	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atatgaaaaaatacaaaattCaaaaggtgagtataagggac	8	3	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:166254772C>G	uc003ire.2	+	2	380	c.250C>G	c.(250-252)CAA>GAA	p.Q84E	SC4MOL_uc010irb.2_Missense_Mutation_p.Q84E|SC4MOL_uc003irf.2_Intron	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	84					cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	ATACAAAATTCAAAAGGTGAG	0.279													0	0	0	0.038147	0	8	11										G	166254772	C	G	166254772	3	3	124	1	0	0	0	0	1	0	0	0	13865	827	29	1	252	1	SC4MOL	4	166254772	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	3299976	166254772	24899504	54	37032										
SC4MOL	6307	broad.mit.edu	37	chr4	166263045	166263045	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gaatttttggaacagactctCagtataatgcctataatgaa	7	6	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:166263045C>A	uc003ire.2	+	6	959	c.829C>A	c.(829-831)CAG>AAG	p.Q277K	SC4MOL_uc003irf.2_Missense_Mutation_p.Q146K	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	277					cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)	AACAGACTCTCAGTATAATGC	0.363													1	0	6.31663e-08	0.024245	6.66906e-08	15	17										A	166263045	C	A	166263045	3	1	124	1	0	0	0	0	1	0	0	0	13865	827	29	3	847	3	SC4MOL	4	166263045	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	8273	166263045	24891231	55	37033										
KIAA1430	57587	broad.mit.edu	37	chr4	186112120	186112120	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcattctctacggggtgttcTgggggaaatttcacgtttct	11	8	5	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr4:186112120T>C	uc003ixf.3	-	2	378	c.231A>G	c.(229-231)CCA>CCG	p.P77P	KIAA1430_uc003ixg.2_Silent_p.P77P	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	77											0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		CGGGGTGTTCTGGGGGAAATT	0.348													0	0	0	0.02938	0	7	13										C	186112120	T	C	186112120	2	2	124	1	0	0	0	0	0	0	0	1	8232	1567	55	5		5	KIAA1430	4	186112120	Silent	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	19849075	186112120	5042156	56	37034										
IL7R	3575	broad.mit.edu	37	chr5	35874558	35874558	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcttgctttccaggggagatGgatcctatcttactaaccat	8	10	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:35874558G>A	uc003jjs.2	+	6	803	c.714G>A	c.(712-714)ATG>ATA	p.M238I	IL7R_uc011coo.1_Intron|IL7R_uc011cop.1_Intron	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	238	Extracellular (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CAGGGGAGATGGATCCTATCT	0.448													0	0	0	0.034045	0	30	98										A	35874558	G	A	35874558	3	1	124	1	0	0	0	0	1	0	0	0	7705	1348	47	2	736	2	IL7R	5	35874558	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		35874558	145040702	57	37035										
NUP155	9631	broad.mit.edu	37	chr5	37371058	37371058	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgtagaggccggcatcgccgCgcccaacaaagaagacggca	13	13	0	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:37371058C>T	uc003jku.1	-	1	140	c.22G>A	c.(22-24)GCG>ACG	p.A8T	NUP155_uc003jkt.1_5'Flank|NUP155_uc010iuz.1_Missense_Mutation_p.A8T	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	8					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGCATCGCCGCGCCCAACAAA	0.527													0	0	0	0.020292	0	15	106										T	37371058	C	T	37371058	3	4	124	1	0	0	0	0	1	0	0	0	10756	768	27	2	4293	2	NUP155	5	37371058	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1496500	37371058	143544202	58	37036										
GHR	2690	broad.mit.edu	37	chr5	42689121	42689121	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acagctgttctataccagaaGgtgccaccatcatgcctttc	7	13	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:42689121G>T	uc003jmt.2	+	4	309	c.266G>T	c.(265-267)AGG>ATG	p.R89M	GHR_uc011cpq.1_Intron	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	89	Extracellular (Potential).		R -> K (in LARS).		2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TATACCAGAAGGTGCCACCAT	0.453													1	0	6.49762e-13	0.038395	7.07263e-13	19	111										T	42689121	G	T	42689121	3	4	124	1	0	0	0	0	1	0	0	0	6371	1014	35	4	276	4	GHR	5	42689121	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	5318063	42689121	138226139	59	37037										
ZNF608	57507	broad.mit.edu	37	chr5	123977030	123977030	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtgtgcaggtgccgctggccGaagggggagtggcgatccct	19	10	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:123977030G>T	uc003ktq.1	-	7	4488	c.4365C>A	c.(4363-4365)TTC>TTA	p.F1455L	ZNF608_uc003ktr.1_Intron|ZNF608_uc003ktp.1_Missense_Mutation_p.F150L	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1455						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCGCTGGCCGAAGGGGGAGT	0.567													1	0	1.15505e-17	0.11126	1.27992e-17	46	51										T	123977030	G	T	123977030	3	4	124	1	0	0	0	0	1	0	0	0	18031	1049	37	3	185	3	ZNF608	5	123977030	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	81287909	123977030	56938230	60	37038										
PHF15	23338	broad.mit.edu	37	chr5	133909338	133909338	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctctcttgttttctcaggttAgaaatctgtgctacatggtg	9	8	3	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:133909338A>G	uc003kzo.1	+	10	1617	c.1438A>G	c.(1438-1440)AGA>GGA	p.R480G	PHF15_uc011cxt.1_Missense_Mutation_p.R480G|PHF15_uc003kzk.2_Missense_Mutation_p.R496G|PHF15_uc003kzl.2_Missense_Mutation_p.R480G|PHF15_uc003kzm.2_Missense_Mutation_p.R480G|PHF15_uc003kzn.2_Intron|PHF15_uc003kzp.2_Missense_Mutation_p.R188G	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	480					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCTCAGGTTAGAAATCTGTG	0.512													0	0	0	0.059317	0	36	12										G	133909338	A	G	133909338	3	3	124	1	0	0	0	0	1	0	0	0	11826	412	15	5	1472	5	PHF15	5	133909338	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	9932308	133909338	47005922	61	37039										
GLRA1	2741	broad.mit.edu	37	chr5	151202511	151202511	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agaagttaaagcggccttctCcagcttcatcctcctggaat	8	12	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:151202511C>G	uc003lut.2	-	9	1384	c.1097G>C	c.(1096-1098)GGA>GCA	p.G366A	GLRA1_uc003lur.2_Missense_Mutation_p.G358A|GLRA1_uc003lus.2_Missense_Mutation_p.G275A	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	366	Cytoplasmic (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GCGGCCTTCTCCAGCTTCATC	0.562													0	0	0	0.080935	0	11	16										G	151202511	C	G	151202511	3	3	124	1	0	0	0	0	1	0	0	0	6454	855	30	1	280	1	GLRA1	5	151202511	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	17293173	151202511	29712749	62	37040										
C5orf41	153222	broad.mit.edu	37	chr5	172517872	172517872	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aaggtgaactttcatgttgaAtgtaaagactatgtaaaaaa	8	3	1	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr5:172517872A>G	uc003mch.2	+	4	994	c.690A>G	c.(688-690)GAA>GAG	p.E230E	C5orf41_uc003mcg.2_Silent_p.E230E|C5orf41_uc003mcf.2_Silent_p.E230E|C5orf41_uc011dfd.1_Silent_p.E230E	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	230							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTCATGTTGAATGTAAAGACT	0.413													0	0	0	0.034045	0	31	13										G	172517872	A	G	172517872	2	3	124	1	0	0	0	0	0	0	0	1	2300	98	4	5		5	C5orf41	5	172517872	Silent	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	21315361	172517872	8397388	63	37041										
SLC22A23	63027	broad.mit.edu	37	chr6	3273582	3273582	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcctttctggttgtgcagctCgatgatgggtgccgtcagca	14	10	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:3273582C>T	uc003mvm.3	-	10	1768	c.1768G>A	c.(1768-1770)GAG>AAG	p.E590K	uc003mvi.1_Intron|SLC22A23_uc003mvn.3_Missense_Mutation_p.E309K|SLC22A23_uc003mvo.3_Missense_Mutation_p.E309K|SLC22A23_uc003mvp.1_RNA	NM_015482	NP_056297	A1A5C7	S22AN_HUMAN	solute carrier family 22, member 23 isoform a	590					ion transport	integral to membrane	transmembrane transporter activity			ovary(1)	1	Ovarian(93;0.0493)	all_hematologic(90;0.0905)				ttgtgcagctcgatGATGGGT	0.478													0	0	0	0.021553	0	6	112										T	3273582	C	T	3273582	3	4	124	1	0	0	0	0	1	0	0	0	14452	893	31	1	296	1	SLC22A23	6	3273582	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		3273582	167841485	64	37042										
C6orf106	64771	broad.mit.edu	37	chr6	34574587	34574587	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tttccttctaccttacgatgCggctgtgtgttgaactccgt	9	11	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:34574587C>G	uc003ojr.2	-	4	851	c.606G>C	c.(604-606)CCG>CCC	p.P202P	C6orf106_uc003ojs.2_Silent_p.P136P	NM_024294	NP_077270	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106 isoform a	202										skin(2)|ovary(1)	3						CCTTACGATGCGGCTGTGTGT	0.478													0	0	0	0.009096	0	4	77										G	34574587	C	G	34574587	2	3	124	1	0	0	0	0	0	0	0	1	2319	755	27	4		4	C6orf106	6	34574587	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	31301005	34574587	136540480	65	37043										
ETV7	51513	broad.mit.edu	37	chr6	36334426	36334426	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggagtccacctgcccctcacGgagagatttctggcctcttg	11	14	3	1	rs145392208	byFrequency	TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:36334426G>A	uc003omb.2	-	8	1171	c.1022C>T	c.(1021-1023)CCG>CTG	p.P341L	ETV7_uc003olz.1_Intron|ETV7_uc003oma.1_Intron|ETV7_uc010jwg.2_RNA|ETV7_uc003omc.2_Missense_Mutation_p.P286L|ETV7_uc010jwj.2_Missense_Mutation_p.P282L|ETV7_uc010jwh.2_Missense_Mutation_p.P260L|ETV7_uc010jwi.2_Missense_Mutation_p.P264L|ETV7_uc011dtl.1_Missense_Mutation_p.P190L	NM_016135	NP_057219	Q9Y603	ETV7_HUMAN	ets variant 7	341					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						TGCCCCTCACGGAGAGATTTC	0.622													0	0	0	0.069456	0	36	97										A	36334426	G	A	36334426	3	1	124	1	0	0	0	0	1	0	0	0	5284	1116	39	2	7	2	ETV7	6	36334426	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1759839	36334426	134780641	66	37044										
DNAH8	1769	broad.mit.edu	37	chr6	38723820	38723820	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acggtgtgtcaaggtattatAatacctcagagagaatgacc	10	7	2	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:38723820A>G	uc003ooe.1	+	8	1429	c.829A>G	c.(829-831)AAT>GAT	p.N277D		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAGGTATTATAATACCTCAGA	0.348													0	0	0	0.055883	0	18	44										G	38723820	A	G	38723820	3	3	124	1	0	0	0	0	1	0	0	0	4607	362	13	5	851	5	DNAH8	6	38723820	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	2389394	38723820	132391247	67	37045										
KIF6	221458	broad.mit.edu	37	chr6	39507890	39507890	+	Frame_Shift_Del	DEL	G	G	-													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttcttctgggtttcctaggcGgaagggtgggctctgggact							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:39507890delG	uc003oot.2	-	13	1629	c.1534delC	c.(1534-1536)CGCfs	p.R512fs	KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Frame_Shift_Del_p.R303fs|KIF6_uc011dua.1_Frame_Shift_Del_p.R512fs|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	512					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TTTCCTAGGCGGAAGGGTGGG	0.498																		8	254	---	---								-	39507890	G	-	39507890	7	5	124	1	0	1	0	1	0	0	0	0	8308	1116	39	0	954	0	KIF6	6	39507890	Frame_Shift_Del	DEL	G	TCGA-GV-A40G-01A-11D-A23M-08	784070	39507890	131607177	68	37046										
LAMA2	3908	broad.mit.edu	37	chr6	129649559	129649559	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgaaacatcgatatgccaggTagtcctctgagccttccttg	9	11	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:129649559T>C	uc003qbn.2	+	29	4416	c.4311_splice	c.e29+2	p.Q1437_splice	LAMA2_uc003qbo.2_Splice_Site_p.Q1437_splice	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATATGCCAGGTAGTCCTCTGA	0.532													0	0	0	0.014758	0	4	67										C	129649559	T	C	129649559	5	2	124	1	0	0	0	0	0	0	1	0	8606	1652	57	5	4427	5	LAMA2	6	129649559	Splice_Site	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	90141669	129649559	41465508	69	37047										
NMBR	4829	broad.mit.edu	37	chr6	142409489	142409489	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccactcgtcgaagaagtagcGcgaggcgtccaccgggacgc	14	14	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:142409489G>A	uc003qiu.2	-	1	448	c.307C>T	c.(307-309)CGC>TGC	p.R103C		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	103	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AAGAAGTAGCGCGAGGCGTCC	0.602													0	0	0	0.048971	0	75	13										A	142409489	G	A	142409489	3	1	124	1	0	0	0	0	1	0	0	0	10487	1087	38	2	877	2	NMBR	6	142409489	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	12759930	142409489	28705578	70	37048										
SYNE1	23345	broad.mit.edu	37	chr6	152651705	152651705	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agagaaagagcctcctcaacGgccaggtcggtgggaacttt	13	10	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr6:152651705G>A	uc010kiw.2	-	78	14717	c.14115C>T	c.(14113-14115)GCC>GCT	p.A4705A	SYNE1_uc003qot.3_Silent_p.A4634A|SYNE1_uc003qou.3_Silent_p.A4705A|SYNE1_uc010kiz.2_Silent_p.A460A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4705	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTCCTCAACGGCCAGGTCGG	0.522										HNSCC(10;0.0054)			0	0	0	0.076483	0	22	7										A	152651705	G	A	152651705	2	1	124	1	0	0	0	0	0	0	0	1	15442	1103	39	2		2	SYNE1	6	152651705	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	10242216	152651705	18463362	71	37049										
EVX1	2128	broad.mit.edu	37	chr7	27285924	27285924	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccccgggctgccgccgcctcGgacttcacctgtgcctccac	10	21	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:27285924G>A	uc003szd.1	+	3	1590	c.1104G>A	c.(1102-1104)TCG>TCA	p.S368S	EVX1_uc011jzn.1_Silent_p.S186S|EVX1_uc010kuy.1_3'UTR	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	368	Ala-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						CCGCCGCCTCGGACTTCACCT	0.751													0	0	0	0.058154	0	8	5										A	27285924	G	A	27285924	2	1	124	1	0	0	0	0	0	0	0	1	5294	1103	39	2		2	EVX1	7	27285924	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		27285924	131852739	72	37050										
AVL9	23080	broad.mit.edu	37	chr7	32598622	32598622	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agatggtgggcttcaggaaaGtaacccatgtgcagatgatt	13	6	1	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:32598622G>C	uc003tcv.1	+	10	907	c.761G>C	c.(760-762)AGT>ACT	p.S254T	AVL9_uc011kai.1_Missense_Mutation_p.S254T|AVL9_uc010kwj.1_Missense_Mutation_p.S95T	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	254						integral to membrane					0						CTTCAGGAAAGTAACCCATGT	0.423													0	0	0	0.0333	0	18	46										C	32598622	G	C	32598622	3	2	124	1	0	0	0	0	1	0	0	0	1228	1029	36	4	799	4	AVL9	7	32598622	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	5312698	32598622	126540041	73	37051										
POU6F2	11281	broad.mit.edu	37	chr7	39379526	39379526	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccagaaccaaccatctccaaCccagcagagctccagccccc	5	21	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:39379526C>T	uc003thb.1	+	5	839	c.797C>T	c.(796-798)ACC>ATC	p.T266I	POU6F2_uc010kxo.2_Missense_Mutation_p.T258I	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	266	Pro-rich.|Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						ccatctccaacccagcagagc	0.244													0	0	0	0.062417	0	23	45										T	39379526	C	T	39379526	3	4	124	1	0	0	0	0	1	0	0	0	12285	507	18	2	815	2	POU6F2	7	39379526	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	6780904	39379526	119759137	74	37052										
ABHD11	83451	broad.mit.edu	37	chr7	73153094	73153094	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cctccaggctcgggtccagcGgagcatgcttgcaagctgtt	13	13	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:73153094G>A	uc003tzb.2	-	1	91	c.34C>T	c.(34-36)CGC>TGC	p.R12C	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Missense_Mutation_p.R12C|ABHD11_uc003tzc.2_Missense_Mutation_p.R12C|ABHD11_uc003tza.2_5'UTR|ABHD11_uc003tzf.2_Missense_Mutation_p.R12C|ABHD11_uc011kfc.1_Missense_Mutation_p.R12C	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	12							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CGGGTCCAGCGGAGCATGCTT	0.532													0	0	0	0.038147	0	8	26										A	73153094	G	A	73153094	3	1	124	1	0	0	0	0	1	0	0	0	75	1116	39	2	1208	2	ABHD11	7	73153094	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	33773568	73153094	85985569	75	37053										
CALCR	799	broad.mit.edu	37	chr7	93055890	93055890	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgggcccattggcgcttcacGgtggtttggacctggaagag	16	9	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:93055890G>A	uc003umv.1	-	15	1566	c.1305C>T	c.(1303-1305)ACC>ACT	p.T435T	CALCR_uc011kia.1_Silent_p.T215T|CALCR_uc003ums.1_RNA|CALCR_uc003umt.1_RNA|CALCR_uc003umu.1_Silent_p.T401T|CALCR_uc003umw.2_Silent_p.T401T	NM_001742	NP_001733	P30988	CALCR_HUMAN	calcitonin receptor isoform 2 precursor	417	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin binding|calcitonin receptor activity|calcitonin receptor activity|protein binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GGCGCTTCACGGTGGTTTGGA	0.522													0	0	0	0.064281	0	36	38										A	93055890	G	A	93055890	2	1	124	1	0	0	0	0	0	0	0	1	2579	1103	39	2		2	CALCR	7	93055890	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	19902796	93055890	66082773	76	37054										
DYNC1I1	1780	broad.mit.edu	37	chr7	95442532	95442532	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gccgctgcattttttaacatGggatacctgttattttcatt	7	8	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:95442532G>A	uc003uoc.3	+	4	525	c.248G>A	c.(247-249)TGG>TAG	p.W83*	DYNC1I1_uc003uod.3_Intron|DYNC1I1_uc003uob.2_Intron|DYNC1I1_uc003uoe.3_Nonsense_Mutation_p.W83*|DYNC1I1_uc010lfl.2_Intron	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	83	Interaction with DCTN1 (By similarity).				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TTTTTAACATGGGATACCTGT	0.458													0	0	0	0.048971	0	46	35										A	95442532	G	A	95442532	4	1	124	1	0	0	0	0	0	1	0	0	4842	1357	47	2	258	2	DYNC1I1	7	95442532	Nonsense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2386642	95442532	63696131	77	37055										
PILRA	29992	broad.mit.edu	37	chr7	99997420	99997420	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcgcccaggatgacggcatcGtctatgcttcccttgccctc	9	16	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:99997420G>A	uc003uuo.1	+	7	1014	c.802G>A	c.(802-804)GTC>ATC	p.V268I	PILRA_uc011kjo.1_Intron|PILRA_uc003uup.1_Missense_Mutation_p.V195I|PILRA_uc003uuq.1_3'UTR	NM_013439	NP_038467	Q9UKJ1	PILRA_HUMAN	paired immunoglobulin-like type 2 receptor alpha	268	Cytoplasmic (Potential).|ITIM motif 1.				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGACGGCATCGTCTATGCTTC	0.587													0	0	0	0.080422	0	40	139										A	99997420	G	A	99997420	3	1	124	1	0	0	0	0	1	0	0	0	11925	1145	40	2	828	2	PILRA	7	99997420	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	4554888	99997420	59141243	78	37056										
TRIM56	81844	broad.mit.edu	37	chr7	100731304	100731304	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gaggcagcgcggagggtggaGaaggaggcgctagcccggct	21	9	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:100731304G>A	uc003uxq.2	+	3	942	c.711G>A	c.(709-711)GAG>GAA	p.E237E	TRIM56_uc003uxr.2_Silent_p.E237E	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	237	Potential.				defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAGGGTGGAGAAGGAGGCGC	0.726													0	0	0	0.004672	0	3	9										A	100731304	G	A	100731304	2	1	124	1	0	0	0	0	0	0	0	1	16527	933	33	1		1	TRIM56	7	100731304	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	733884	100731304	58407359	79	37057										
DLD	1738	broad.mit.edu	37	chr7	107546721	107546721	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttttcttacagatagatgaaGatacaatagtgtcatctaca	6	6	3	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:107546721G>A	uc003vet.2	+	8	702	c.592G>A	c.(592-594)GAT>AAT	p.D198N	DLD_uc010ljm.1_RNA|DLD_uc011kmg.1_Missense_Mutation_p.D150N|DLD_uc011kmh.1_Missense_Mutation_p.D175N|DLD_uc011kmi.1_Missense_Mutation_p.D99N	NM_000108	NP_000099	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase precursor	198					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			central_nervous_system(1)	1					NADH(DB00157)	GATAGATGAAGATACAATAGT	0.234													0	0	0	0.047766	0	8	25										A	107546721	G	A	107546721	3	1	124	1	0	0	0	0	1	0	0	0	4551	942	33	1	622	1	DLD	7	107546721	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	6815417	107546721	51591942	80	37058										
ZYX	7791	broad.mit.edu	37	chr7	143085644	143085644	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagccgtccgcgctctagggCagctgttccacatcgcctgc	11	17	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:143085644C>G	uc003wcw.2	+	7	1362	c.1207C>G	c.(1207-1209)CAG>GAG	p.Q403E	ZYX_uc011ktd.1_Missense_Mutation_p.Q246E|ZYX_uc003wcx.2_Missense_Mutation_p.Q403E|ZYX_uc011kte.1_Missense_Mutation_p.Q372E|ZYX_uc011ktf.1_Missense_Mutation_p.Q246E	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	403	LIM zinc-binding 1.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CGCTCTAGGGCAGCTGTTCCA	0.642													0	0	0	0.030593	0	26	84										G	143085644	C	G	143085644	3	3	124	1	0	0	0	0	1	0	0	0	18251	711	25	4	1229	4	ZYX	7	143085644	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	35538923	143085644	16053019	81	37059										
SSPO	23145	broad.mit.edu	37	chr7	149512268	149512268	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tttcttcctgcgtagactgcGggggtggccagagtctgcat	14	10	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr7:149512268G>A	uc010lpk.2	+	76	10588	c.10588G>A	c.(10588-10590)GGG>AGG	p.G3530R		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3530					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGTAGACTGCGGGGGTGGCCA	0.662													0	0	0	0.024245	0	14	42										A	149512268	G	A	149512268	3	1	124	1	0	0	0	0	1	0	0	0	15188	1116	39	2	10880	2	SSPO	7	149512268	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	6426624	149512268	9626395	82	37060										
MYOM2	9172	broad.mit.edu	37	chr8	2026821	2026821	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tttttaacttgaagatgtgaAgtaggaacgaataattgggt	11	2	0	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:2026821A>C	uc003wpx.3	+	12	1407	c.1269A>C	c.(1267-1269)GAA>GAC	p.E423D	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	423	Fibronectin type-III 1.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GAAGATGTGAAGTAGGAACGA	0.378													0	0	0	0.050027	0	31	17										C	2026821	A	C	2026821	3	2	124	1	0	0	0	0	1	0	0	0	10092	69	3	5	1311	5	MYOM2	8	2026821	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08		2026821	144337201	83	37061										
AMAC1L2	83650	broad.mit.edu	37	chr8	11189370	11189370	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gttgcccagtgacctcctgaGttggagttgtgtgggggcag	17	8	0	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:11189370G>A	uc003wtp.1	+	1	876	c.755G>A	c.(754-756)AGT>AAT	p.S252N		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	252	Helical; (Potential).					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		GACCTCCTGAGTTGGAGTTGT	0.632													0	0	0	0.02938	0	4	57										A	11189370	G	A	11189370	3	1	124	1	0	0	0	0	1	0	0	0	560	1029	36	2	757	2	AMAC1L2	8	11189370	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	9162549	11189370	135174652	84	37062										
PXDNL	137902	broad.mit.edu	37	chr8	52321799	52321799	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atgcgcgtgtagctgtggtcGggggtgacggccgccgcgcg	20	11	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:52321799G>A	uc003xqu.3	-	17	2486	c.2385C>T	c.(2383-2385)CCC>CCT	p.P795P	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	795					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AGCTGTGGTCGGGGGTGACGG	0.726													0	0	0	0.004672	0	3	3										A	52321799	G	A	52321799	2	1	124	1	0	0	0	0	0	0	0	1	12848	1103	39	2		2	PXDNL	8	52321799	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	41132429	52321799	94042223	85	37063										
PREX2	80243	broad.mit.edu	37	chr8	69020396	69020396	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tacttttaaacaggccaaatCtaaaatctccccactgcaca	3	13	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:69020396C>T	uc003xxv.1	+	24	2795	c.2768C>T	c.(2767-2769)TCT>TTT	p.S923F	PREX2_uc011lez.1_Missense_Mutation_p.S858F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	923					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CAGGCCAAATCTAAAATCTCC	0.403													0	0	0	0.014758	0	5	32										T	69020396	C	T	69020396	3	4	124	1	0	0	0	0	1	0	0	0	12477	913	32	1	3091	1	PREX2	8	69020396	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	16698597	69020396	77343626	86	37064										
PKHD1L1	93035	broad.mit.edu	37	chr8	110457754	110457754	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aagtctactgccgcactcccGctgggaccactggaatggtc	11	14	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:110457754G>A	uc003yne.2	+	38	5760	c.5656G>A	c.(5656-5658)GCT>ACT	p.A1886T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1886	Extracellular (Potential).|IPT/TIG 11.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCGCACTCCCGCTGGGACCAC	0.433										HNSCC(38;0.096)			0	0	0	0.004672	0	3	16										A	110457754	G	A	110457754	3	1	124	1	0	0	0	0	1	0	0	0	11972	1087	38	2	5806	2	PKHD1L1	8	110457754	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	41437358	110457754	35906268	87	37065										
RAD21	5885	broad.mit.edu	37	chr8	117866640	117866640	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctaagttgggctctaattgtCttgctatccaactctttgac	7	10	3	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:117866640C>G	uc003yod.2	-	9	1293	c.1005G>C	c.(1003-1005)AAG>AAC	p.K335N		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	335	Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					CTCTAATTGTCTTGCTATCCA	0.378													0	0	0	0.028581	0	14	57										G	117866640	C	G	117866640	3	3	124	1	0	0	0	0	1	0	0	0	12981	912	32	1	914	1	RAD21	8	117866640	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	7408886	117866640	28497382	88	37066										
ADCY8	114	broad.mit.edu	37	chr8	131922042	131922042	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cttccttagtcccaaaacacCgcacagcaccgagccggagt	8	16	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:131922042C>T	uc003ytd.3	-	6	1808	c.1552G>A	c.(1552-1554)GGT>AGT	p.G518S	ADCY8_uc010mds.2_Missense_Mutation_p.G518S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	518	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CCCAAAACACCGCACAGCACC	0.473										HNSCC(32;0.087)			0	0	0	0.048971	0	63	51										T	131922042	C	T	131922042	3	4	124	1	0	0	0	0	1	0	0	0	300	652	23	2	2255	2	ADCY8	8	131922042	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	14055402	131922042	14441980	89	37067										
SLC45A4	57210	broad.mit.edu	37	chr8	142228784	142228784	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagcagctcgggctccaggtCcagcgcggtgtccggcacgt	15	15	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:142228784C>T	uc003ywd.1	-	4	1110	c.802G>A	c.(802-804)GAC>AAC	p.D268N	SLC45A4_uc003ywc.1_Missense_Mutation_p.D268N|SLC45A4_uc010meq.1_Missense_Mutation_p.D266N	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	319					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGCTCCAGGTCCAGCGCGGTG	0.672													0	0	0	0.086207	0	39	86										T	142228784	C	T	142228784	3	4	124	1	0	0	0	0	1	0	0	0	14643	855	30	1	1614	1	SLC45A4	8	142228784	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	10306742	142228784	4135238	90	37068										
TOP1MT	116447	broad.mit.edu	37	chr8	144406198	144406198	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gaaatacagggccaccgcccGctgtctcgtcttcatttccc	8	16	3	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr8:144406198G>A	uc003yxz.2	-	7	950	c.931C>T	c.(931-933)CGG>TGG	p.R311W	TOP1MT_uc011lkd.1_Missense_Mutation_p.R213W|TOP1MT_uc011lke.1_Missense_Mutation_p.R213W|TOP1MT_uc010mfb.2_Missense_Mutation_p.R213W|TOP1MT_uc011lkf.1_Missense_Mutation_p.R106W|TOP1MT_uc010mfd.1_Missense_Mutation_p.R106W	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	311					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GCCACCGCCCGCTGTCTCGTC	0.582													0	0	0	0.048971	0	66	48										A	144406198	G	A	144406198	3	1	124	1	0	0	0	0	1	0	0	0	16361	1086	38	2	906	2	TOP1MT	8	144406198	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2177414	144406198	1957824	91	37069										
SPAG8	26206	broad.mit.edu	37	chr9	35811307	35811307	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttctaagacttgcaaaaattCccaaggtggttgtttctggg	10	7	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:35811307C>T	uc003zye.2	-	2	851	c.736G>A	c.(736-738)GAA>AAA	p.E246K	SPAG8_uc003zyf.2_Missense_Mutation_p.E163K|SPAG8_uc003zyg.2_Missense_Mutation_p.E246K	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	246						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			TGCAAAAATTCCCAAGGTGGT	0.532													0	0	0	0.069234	0	10	345										T	35811307	C	T	35811307	3	4	124	1	0	0	0	0	1	0	0	0	14984	864	30	1	996	1	SPAG8	9	35811307	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		35811307	105402124	92	37070										
NIPSNAP3B	55335	broad.mit.edu	37	chr9	107531159	107531159	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	catagataattttgctcatcGagctgaagttcggaaagcct	9	8	1	2	rs141198887	byFrequency	TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:107531159G>A	uc004bci.2	+	3	358	c.287G>A	c.(286-288)CGA>CAA	p.R96Q	NIPSNAP3A_uc011lvu.1_Intron|NIPSNAP3B_uc004bcj.1_RNA	NM_018376	NP_060846	Q9BS92	NPS3B_HUMAN	nipsnap homolog 3B	96										pancreas(1)|skin(1)	2						TTTGCTCATCGAGCTGAAGTT	0.343													0	0	0	0.047766	0	8	20										A	107531159	G	A	107531159	3	1	124	1	0	0	0	0	1	0	0	0	10431	1058	37	1	297	1	NIPSNAP3B	9	107531159	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	71719852	107531159	33682272	93	37071										
SVEP1	79987	broad.mit.edu	37	chr9	113252013	113252013	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgatagcaacatctccaattGggaaaaggtaaggtggggtg	14	6	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:113252013G>C	uc010mtz.2	-	9	2184	c.1847C>G	c.(1846-1848)CCA>CGA	p.P616R	SVEP1_uc010mua.1_Missense_Mutation_p.P616R|SVEP1_uc004beu.2_Missense_Mutation_p.P616R	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	616	HYR 1.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ATCTCCAATTGGGAAAAGGTA	0.398													0	0	0	0.062417	0	21	44										C	113252013	G	C	113252013	3	2	124	1	0	0	0	0	1	0	0	0	15417	1348	47	4	9028	4	SVEP1	9	113252013	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	5720854	113252013	27961418	94	37072										
LRSAM1	90678	broad.mit.edu	37	chr9	130265127	130265127	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagccactgcgcacctgcccGctgtgccgccaggacatcgc	11	19	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:130265127G>A	uc004brb.1	+	26	2466	c.2121G>A	c.(2119-2121)CCG>CCA	p.P707P	LRSAM1_uc010mxk.1_Silent_p.P680P|LRSAM1_uc004brc.1_Silent_p.P707P|LRSAM1_uc004brd.1_Silent_p.P707P|LRSAM1_uc004bre.1_Silent_p.P287P|LRSAM1_uc004brg.1_Silent_p.P138P	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	707	RING-type.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GCACCTGCCCGCTGTGCCGCC	0.682													0	0	0	0.058154	0	10	7										A	130265127	G	A	130265127	2	1	124	1	0	0	0	0	0	0	0	1	9043	1074	38	2		2	LRSAM1	9	130265127	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	17013114	130265127	10948304	95	37073										
ABO	28	broad.mit.edu	37	chr9	136137502	136137502	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gatggtcaaatgtgtcttacCcaaacaagaccaagacaagc	8	10	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:136137502C>T	uc004cda.1	-	2	123	c.98G>A	c.(97-99)GGT>GAT	p.G33D	ABO_uc010naf.1_5'UTR|ABO_uc011mcz.1_5'UTR|ABO_uc010nag.1_Intron	NM_020469	NP_065202	P16442	BGAT_HUMAN	ABO blood group (alpha	33	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		TGTGTCTTACCCAAACAAGAC	0.488													0	0	0	0.009096	0	4	11										T	136137502	C	T	136137502	3	4	124	1	0	0	0	0	1	0	0	0	97	637	22	2	989	2	ABO	9	136137502	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	5872375	136137502	5075929	96	37074										
ADAMTSL2	9719	broad.mit.edu	37	chr9	136409600	136409600	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttttgcctccaggttactctCtggtgacccacatcccggct	8	15	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:136409600C>T	uc011mdl.1	+	8	1248	c.691C>T	c.(691-693)CTG>TTG	p.L231L	ADAMTSL2_uc004cei.2_Silent_p.L231L	NM_001145320	NP_001138792	Q86TH1	ATL2_HUMAN	ADAMTS-like 2 precursor	231					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		AGGTTACTCTCTGGTGACCCA	0.587													0	0	0	0.045515	0	43	54										T	136409600	C	T	136409600	2	4	124	1	0	0	0	0	0	0	0	1	275	912	32	1		1	ADAMTSL2	9	136409600	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	272098	136409600	4803831	97	37075										
RXRA	6256	broad.mit.edu	37	chr9	137321028	137321028	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acgggatcctcctggccaccGggctgcacgtccaccggaac	12	17	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:137321028G>A	uc004cfb.2	+	7	1147	c.985G>A	c.(985-987)GGG>AGG	p.G329R	RXRA_uc004cfc.1_Missense_Mutation_p.G232R	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	329	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCTGGCCACCGGGCTGCACGT	0.682													0	0	0	0.030593	0	28	51										A	137321028	G	A	137321028	3	1	124	1	0	0	0	0	1	0	0	0	13763	1116	39	2	1011	2	RXRA	9	137321028	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	911428	137321028	3892403	98	37076										
MAMDC4	158056	broad.mit.edu	37	chr9	139750013	139750013	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggggacctgtgtgtgcccccGgaacaactgtgtgacttcga	14	11	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr9:139750013G>A	uc004cjs.2	+	12	1463	c.1413G>A	c.(1411-1413)CCG>CCA	p.P471P	MAMDC4_uc011mej.1_Intron	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	471	Extracellular (Potential).|LDL-receptor class A 3.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GTGTGCCCCCGGAACAACTGT	0.701													0	0	0	0.004672	0	3	10										A	139750013	G	A	139750013	2	1	124	1	0	0	0	0	0	0	0	1	9204	1103	39	2		2	MAMDC4	9	139750013	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2428985	139750013	1463418	99	37077										
PITRM1	10531	broad.mit.edu	37	chr10	3180309	3180309	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtgtgtgctcttcccagtgcCgaggtatctgagaggaaggc	15	9	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr10:3180309C>T	uc010qah.1	-	24	2766	c.2734G>A	c.(2734-2736)GGC>AGC	p.G912S	PITRM1_uc001igr.1_3'UTR|PITRM1_uc001igs.1_Missense_Mutation_p.G115S|PITRM1_uc001igt.1_Missense_Mutation_p.G1010S			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	912					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						TTCCCAGTGCCGAGGTATCTG	0.607													0	0	0	0.021553	0	5	6										T	3180309	C	T	3180309	3	4	124	1	0	0	0	0	1	0	0	0	11953	652	23	2	89	2	PITRM1	10	3180309	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		3180309	132354438	100	37078										
CDH23	64072	broad.mit.edu	37	chr10	73571082	73571082	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cctcgcccagggtgatccagAtgatcgatgagaacaaggag	13	10	0	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr10:73571082A>G	uc001jrx.3	+	61	9465	c.9088A>G	c.(9088-9090)ATG>GTG	p.M3030V	CDH23_uc001jsg.3_Missense_Mutation_p.M790V|CDH23_uc001jsh.3_Missense_Mutation_p.M790V|CDH23_uc001jsi.3_Missense_Mutation_p.M790V|CDH23_uc001jsj.3_5'Flank|CDH23_uc010qjr.1_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3030	Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGTGATCCAGATGATCGATGA	0.592													0	0	0	0.09836	0	39	31										G	73571082	A	G	73571082	3	3	124	1	0	0	0	0	1	0	0	0	3108	333	12	5	9679	5	CDH23	10	73571082	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	70390773	73571082	61963665	101	37079										
SORCS3	22986	broad.mit.edu	37	chr10	106982952	106982952	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	caacatcagtgcagtcgtgtGgcccagtcaactggggaccc	12	13	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr10:106982952G>C	uc001kyi.1	+	20	3040	c.2813G>C	c.(2812-2814)TGG>TCG	p.W938S	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	938	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GCAGTCGTGTGGCCCAGTCAA	0.443													0	0	0	0.048971	0	89	16										C	106982952	G	C	106982952	3	2	124	1	0	0	0	0	1	0	0	0	14932	1357	47	4	2891	4	SORCS3	10	106982952	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	33411870	106982952	28551795	102	37080										
FAM175B	23172	broad.mit.edu	37	chr10	126523241	126523241	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	attttcacccaaacaatcaaGaaagtactttgagccactct	4	11	3	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr10:126523241G>A	uc001lib.3	+	9	994	c.949G>A	c.(949-951)GAA>AAA	p.E317K		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	317						BRISC complex	polyubiquitin binding				0						AAACAATCAAGAAAGTACTTT	0.517													0	0	0	0.028581	0	17	37										A	126523241	G	A	126523241	3	1	124	1	0	0	0	0	1	0	0	0	5498	943	33	1	983	1	FAM175B	10	126523241	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	19540289	126523241	9011506	103	37081										
CYP2E1	1571	broad.mit.edu	37	chr10	135350635	135350635	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctgccatcaaggataggcaaGagatgccctacatggatgct	11	10	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr10:135350635G>C	uc001lnj.1	+	7	1069	c.1036G>C	c.(1036-1038)GAG>CAG	p.E346Q	CYP2E1_uc001lnk.1_Missense_Mutation_p.E209Q|CYP2E1_uc009ybl.1_Missense_Mutation_p.E147Q|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Missense_Mutation_p.E147Q	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	346					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	GGATAGGCAAGAGATGCCCTA	0.517									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				0	0	0	0.020292	0	13	41										C	135350635	G	C	135350635	3	2	124	1	0	0	0	0	1	0	0	0	4170	943	33	1	1062	1	CYP2E1	10	135350635	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	8827394	135350635	184112	104	37082										
KRTAP5-1	387264	broad.mit.edu	37	chr11	1605847	1605847	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gaacaggaacagcaacacacGggcacaccgcagccggagcc	12	15	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:1605847G>A	uc001ltu.1	-	1	667	c.633C>T	c.(631-633)CCC>CCT	p.P211P	LOC338651_uc009ycx.1_Intron|LOC338651_uc001ltt.1_Intron	NM_001005922	NP_001005922	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	211	8 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCAACACACGGGCACACCGC	0.657													0	0	0	0.11126	0	40	95										A	1605847	G	A	1605847	2	1	124	1	0	0	0	0	0	0	0	1	8558	1103	39	2		2	KRTAP5-1	11	1605847	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		1605847	133400669	105	37083										
OR51A4	401666	broad.mit.edu	37	chr11	4967470	4967470	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	caataaacaattgggttcgtCagtggaggtacaagtaggag	13	5	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:4967470C>T	uc010qys.1	-	1	861	c.861G>A	c.(859-861)CTG>CTA	p.L287L		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGGGTTCGTCAGTGGAGGTA	0.428													0	0	0	0.041601	0	33	59										T	4967470	C	T	4967470	2	4	124	1	0	0	0	0	0	0	0	1	11087	813	29	1		1	OR51A4	11	4967470	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	3361623	4967470	130039046	106	37084										
OR10A2	341276	broad.mit.edu	37	chr11	6891085	6891085	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgggaaactgcctcatcattCtggttaccctagctgacccc	8	14	3	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:6891085C>A	uc001meu.1	+	1	100	c.100C>A	c.(100-102)CTG>ATG	p.L34M		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	34	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCTCATCATTCTGGTTACCCT	0.463													1	0	9.59835e-30	0.048971	1.09823e-29	56	127										A	6891085	C	A	6891085	3	1	124	1	0	0	0	0	1	0	0	0	10890	912	32	3	102	3	OR10A2	11	6891085	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1923615	6891085	128115431	107	37085										
OR4X2	119764	broad.mit.edu	37	chr11	48267353	48267353	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	caaagccctctccacctgtgGgtcccatttcgctgtggtta	9	14	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:48267353G>A	uc001ngs.1	+	1	698	c.698G>A	c.(697-699)GGG>GAG	p.G233E		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	233	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCACCTGTGGGTCCCATTTC	0.522													0	0	0	0.047766	0	9	47										A	48267353	G	A	48267353	3	1	124	1	0	0	0	0	1	0	0	0	11085	1232	43	2	700	2	OR4X2	11	48267353	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	41376268	48267353	86739163	108	37086										
OR4C3	256144	broad.mit.edu	37	chr11	48346728	48346728	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cactatcacctccagccccaCgctggcttcccctgtgtatt	6	18	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:48346728C>T	uc010rhv.1	+	1	236	c.236C>T	c.(235-237)ACG>ATG	p.T79M		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCCAGCCCCACGCTGGCTTCC	0.448													0	0	0	0.037714	0	31	60										T	48346728	C	T	48346728	3	4	124	1	0	0	0	0	1	0	0	0	11050	536	19	2	238	2	OR4C3	11	48346728	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	79375	48346728	86659788	109	37087										
OR4C13	283092	broad.mit.edu	37	chr11	49974164	49974164	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgtactttttcctggcctatCtctcctttattgatgcctgc	6	12	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:49974164C>T	uc010rhz.1	+	1	190	c.190C>T	c.(190-192)CTC>TTC	p.L64F		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						CCTGGCCTATCTCTCCTTTAT	0.433													0	0	0	0.099896	0	25	242										T	49974164	C	T	49974164	3	4	124	1	0	0	0	0	1	0	0	0	11047	913	32	1	192	1	OR4C13	11	49974164	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1627436	49974164	85032352	110	37088										
OR5B17	219965	broad.mit.edu	37	chr11	58126261	58126261	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aagaacatctgagcagcacaGgcactgtaggagatggcttt	12	8	1	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:58126261G>A	uc010rke.1	-	1	282	c.282C>T	c.(280-282)GCC>GCT	p.A94A		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GAGCAGCACAGGCACTGTAGG	0.483													0	0	0	0.054565	0	33	31										A	58126261	G	A	58126261	2	1	124	1	0	0	0	0	0	0	0	1	11149	987	35	2		2	OR5B17	11	58126261	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	8152097	58126261	76880255	111	37089										
SLC22A12	116085	broad.mit.edu	37	chr11	64368979	64368979	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gggcagtaaagaaggcaacaCatggcacgctggggaactct	14	9	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:64368979C>T	uc001oam.1	+	10	2365	c.1618C>T	c.(1618-1620)CAT>TAT	p.H540Y	SLC22A12_uc001oal.1_Missense_Mutation_p.H319Y|SLC22A12_uc009yps.1_Missense_Mutation_p.H506Y|SLC22A12_uc001oan.1_Missense_Mutation_p.H432Y	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	540					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						GAAGGCAACACATGGCACGCT	0.567													0	0	0	0.021553	0	6	17										T	64368979	C	T	64368979	3	4	124	1	0	0	0	0	1	0	0	0	14443	478	17	2	1656	2	SLC22A12	11	64368979	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	6242718	64368979	70637537	112	37090										
MRPL11	65003	broad.mit.edu	37	chr11	66206132	66206132	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cactgggcctagtgggggccCgggcatggccaggcctgccc	17	15	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:66206132C>G	uc001ohz.3	-	1	179	c.94G>C	c.(94-96)GGG>CGG	p.G32R	MRPL11_uc001ohy.3_Missense_Mutation_p.G32R|MRPL11_uc001oia.3_Intron	NM_016050	NP_057134	Q9Y3B7	RM11_HUMAN	mitochondrial ribosomal protein L11 isoform a	32					translation		structural constituent of ribosome				0						AGTGGGGGCCCGGGCATGGCC	0.697													0	0	0	0.092188	0	38	13										G	66206132	C	G	66206132	3	3	124	1	0	0	0	0	1	0	0	0	9776	652	23	4	581	4	MRPL11	11	66206132	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1837153	66206132	68800384	113	37091										
CLPB	81570	broad.mit.edu	37	chr11	72012890	72012890	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tggtgagcacatctggatggGccttgtctacttcatcaaag	11	9	4	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:72012890G>A	uc001osj.2	-	12	1426	c.1376C>T	c.(1375-1377)GCC>GTC	p.A459V	CLPB_uc010rqx.1_Missense_Mutation_p.A414V|CLPB_uc010rqy.1_Missense_Mutation_p.A400V|CLPB_uc001osk.2_Missense_Mutation_p.A429V|CLPB_uc009ytg.2_RNA|CLPB_uc010rqz.1_Missense_Mutation_p.A258V|CLPB_uc001osi.2_Missense_Mutation_p.A67V	NM_030813	NP_110440	Q9H078	CLPB_HUMAN	caseinolytic peptidase B	459					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			pancreas(1)	1						ATCTGGATGGGCCTTGTCTAC	0.567													0	0	0	0.047766	0	9	265										A	72012890	G	A	72012890	3	1	124	1	0	0	0	0	1	0	0	0	3551	1203	42	2	771	2	CLPB	11	72012890	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	5806758	72012890	62993626	114	37092										
UCP2	7351	broad.mit.edu	37	chr11	73689056	73689056	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggcttcgggggccctcagtaCgcaccatggtcagaatggtg	15	11	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:73689056C>A	uc001oup.1	-	4	592	c.212G>T	c.(211-213)CGT>CTT	p.R71L	UCP2_uc001ouq.1_Missense_Mutation_p.R71L	NM_003355	NP_003346	P55851	UCP2_HUMAN	uncoupling protein 2	71	Solcar 1.				proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)					GCCCTCAGTACGCACCATGGT	0.602													1	0	2.12129e-23	0.048971	2.39374e-23	54	41										A	73689056	C	A	73689056	3	1	124	1	0	0	0	0	1	0	0	0	16928	536	19	4	737	4	UCP2	11	73689056	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1676166	73689056	61317460	115	37093										
CTSC	1075	broad.mit.edu	37	chr11	88070744	88070744	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccaggtgcccagcaggtcaaGataggtgcagttggcaggtg	16	9	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:88070744G>A	uc001pck.3	-	1	198	c.97C>T	c.(97-99)CTT>TTT	p.L33F	CTSC_uc001pcl.3_5'UTR|CTSC_uc001pcm.3_Missense_Mutation_p.L33F|CTSC_uc001pcn.3_Missense_Mutation_p.L33F	NM_001814	NP_001805	P53634	CATC_HUMAN	cathepsin C isoform a preproprotein	33					immune response	lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGCAGGTCAAGATAGGTGCAG	0.672													0	0	0	0.021553	0	5	6										A	88070744	G	A	88070744	3	1	124	1	0	0	0	0	1	0	0	0	4031	942	33	1	1453	1	CTSC	11	88070744	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	14381688	88070744	46935772	116	37094										
FAT3	120114	broad.mit.edu	37	chr11	92532148	92532148	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acaaagcttctattccacctCaatctcagagaacaacacta	3	13	3	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:92532148C>T	uc001pdj.3	+	9	5986	c.5969C>T	c.(5968-5970)TCA>TTA	p.S1990L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1990	Extracellular (Potential).|Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATTCCACCTCAATCTCAGAG	0.428										TCGA Ovarian(4;0.039)			0	0	0	0.048971	0	92	135										T	92532148	C	T	92532148	3	4	124	1	0	0	0	0	1	0	0	0	5691	838	29	1	6003	1	FAT3	11	92532148	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	4461404	92532148	42474368	117	37095										
DIXDC1	85458	broad.mit.edu	37	chr11	111853166	111853166	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttggaacaacaagaatatttAgaaaaagaaatggaggaagc	10	3	0	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:111853166A>G	uc001pml.2	+	8	1170	c.873A>G	c.(871-873)TTA>TTG	p.L291L	DIXDC1_uc001pmm.2_Silent_p.L80L|DIXDC1_uc001pmn.2_5'UTR	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	291	Potential.|Actin-binding.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)		AAGAATATTTAGAAAAAGAAA	0.433											OREG0021331	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	18										G	111853166	A	G	111853166	2	3	124	1	0	0	0	0	0	0	0	1	4541	433	15	5		5	DIXDC1	11	111853166	Silent	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	19321018	111853166	23153350	118	37096										
ABCG4	64137	broad.mit.edu	37	chr11	119020905	119020905	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcgggaggggccctgctggcGcaaaaggggtagggaacagc	20	9	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr11:119020905G>A	uc001pvs.2	+	2	566	c.230G>A	c.(229-231)CGC>CAC	p.R77H	ABCG4_uc009zar.2_Missense_Mutation_p.R77H	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	77	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CCCTGCTGGCGCAAAAGGGGT	0.622													0	0	0	0.048971	0	48	85										A	119020905	G	A	119020905	3	1	124	1	0	0	0	0	1	0	0	0	70	1087	38	2	232	2	ABCG4	11	119020905	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	7167739	119020905	15985611	119	37097										
PRMT8	56341	broad.mit.edu	37	chr12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctcaggtgaacagcccccccTcccagcccccccagcccgtc	7	24	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:3649787T>C	uc001qmf.2	+	2	458	c.91T>C	c.(91-93)TCC>CCC	p.S31P	PRMT8_uc009zed.2_Missense_Mutation_p.S22P|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	31	SH3-binding 1.				regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652													0	0	0	0.059317	0	21	137										C	3649787	T	C	3649787	3	2	124	1	0	0	0	0	1	0	0	0	12542	1551	54	5	97	5	PRMT8	12	3649787	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08		3649787	130202108	120	37098										
GALNT8	26290	broad.mit.edu	37	chr12	4835870	4835870	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcacagcttttcaggcaatgGggcgaggatctttctgaggc	13	9	4	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:4835870G>T	uc001qne.1	+	2	476	c.384G>T	c.(382-384)TGG>TGT	p.W128C		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	128	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						TCAGGCAATGGGGCGAGGATC	0.517													1	0	8.58068e-18	0.034045	9.55135e-18	31	33										T	4835870	G	T	4835870	3	4	124	1	0	0	0	0	1	0	0	0	6219	1241	43	4	390	4	GALNT8	12	4835870	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1186083	4835870	129016025	121	37099										
SOX5	6660	broad.mit.edu	37	chr12	23793806	23793806	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcagctgccatggtagttggGatcagctgaacagggtaagg	16	7	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:23793806G>T	uc001rfw.2	-	8	1059	c.957C>A	c.(955-957)ATC>ATA	p.I319I	SOX5_uc001rfx.2_Silent_p.I306I|SOX5_uc001rfy.2_Silent_p.I306I|SOX5_uc010siv.1_Silent_p.I306I|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Silent_p.I271I	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	319					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TGGTAGTTGGGATCAGCTGAA	0.473													1	0	1.00221e-16	0.048971	1.10558e-16	49	74										T	23793806	G	T	23793806	2	4	124	1	0	0	0	0	0	0	0	1	14954	1164	41	3		3	SOX5	12	23793806	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	18957936	23793806	110058089	122	37100										
DENND5B	160518	broad.mit.edu	37	chr12	31633168	31633168	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtccgtttgtgtcctgaaagAtagccctttaggcatgcaca	10	10	0	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:31633168A>T	uc001rki.1	-	3	445	c.259T>A	c.(259-261)TCT>ACT	p.S87T	DENND5B_uc001rkh.1_Missense_Mutation_p.S122T|DENND5B_uc009zjq.1_Missense_Mutation_p.S6T|DENND5B_uc001rkj.2_Missense_Mutation_p.S109T|DENND5B_uc001rkk.1_Missense_Mutation_p.S9T	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	87	UDENN.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GTCCTGAAAGATAGCCCTTTA	0.353													0	0	0	0.009096	0	3	17										T	31633168	A	T	31633168	3	4	124	1	0	0	0	0	1	0	0	0	4437	333	12	5	3641	5	DENND5B	12	31633168	Missense_Mutation	SNP	A	TCGA-GV-A40G-01A-11D-A23M-08	7839362	31633168	102218727	123	37101										
C12orf35	55196	broad.mit.edu	37	chr12	32136195	32136195	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agtgtcaccgttagttctgtCagaggtcaaaacattgtctg	10	8	5	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:32136195C>A	uc001rks.2	+	4	2720	c.2306C>A	c.(2305-2307)TCA>TAA	p.S769*		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	769										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			TTAGTTCTGTCAGAGGTCAAA	0.378													1	0	2.08457e-15	0.045705	2.27913e-15	32	54										A	32136195	C	A	32136195	4	1	124	1	0	0	0	0	0	1	0	0	1682	838	29	3	2308	3	C12orf35	12	32136195	Nonsense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	503027	32136195	101715700	124	37102										
ARID2	196528	broad.mit.edu	37	chr12	46230707	46230707	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcttcgtttcctattactttCtgcacatagtcattttattt	3	9	3	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:46230707C>T	uc001ros.1	+	8	956	c.956C>T	c.(955-957)TCT>TTT	p.S319F	ARID2_uc001ror.2_Missense_Mutation_p.S319F|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	319					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CTATTACTTTCTGCACATAGT	0.378													0	0	0	0.049695	0	21	58										T	46230707	C	T	46230707	3	4	124	1	0	0	0	0	1	0	0	0	915	913	32	1	986	1	ARID2	12	46230707	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	14094512	46230707	87621188	125	37103										
FMNL3	91010	broad.mit.edu	37	chr12	50044617	50044617	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggtcaagggcagggccctgCgcttttgtcttgaataattc	12	9	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:50044617C>T	uc001ruv.1	-	17	2076	c.1842G>A	c.(1840-1842)GCG>GCA	p.A614A	FMNL3_uc001ruw.1_Silent_p.A563A|FMNL3_uc001rut.1_Silent_p.A180A|FMNL3_uc001ruu.1_Silent_p.A464A	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	614	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						CAGGGCCCTGCGCTTTTGTCT	0.498													0	0	0	0.045705	0	31	79										T	50044617	C	T	50044617	2	4	124	1	0	0	0	0	0	0	0	1	5953	755	27	2		2	FMNL3	12	50044617	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	3813910	50044617	83807278	126	37104										
NR4A1	3164	broad.mit.edu	37	chr12	52449884	52449884	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccctgtggacaagaggcggcGaaaccgctgccagttctgcc	13	14	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:52449884G>A	uc001rzs.2	+	4	1261	c.947G>A	c.(946-948)CGA>CAA	p.R316Q	NR4A1_uc010sno.1_Missense_Mutation_p.R329Q|NR4A1_uc001rzt.2_Missense_Mutation_p.R316Q|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	316	NR C4-type.|Nuclear receptor.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		AAGAGGCGGCGAAACCGCTGC	0.632													0	0	0	0.062417	0	22	96										A	52449884	G	A	52449884	3	1	124	1	0	0	0	0	1	0	0	0	10632	1058	37	1	953	1	NR4A1	12	52449884	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2405267	52449884	81402011	127	37105										
NAB2	4665	broad.mit.edu	37	chr12	57485744	57485744	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	catctatggccgtttcgactCtaagcggcgggagggcaagc	14	11	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:57485744C>G	uc001smz.2	+	2	1298	c.920C>G	c.(919-921)TCT>TGT	p.S307C		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	307	NCD2.				cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CGTTTCGACTCTAAGCGGCGG	0.567													0	0	0	0.009096	0	4	97										G	57485744	C	G	57485744	3	3	124	1	0	0	0	0	1	0	0	0	10132	913	32	1	926	1	NAB2	12	57485744	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	5035860	57485744	76366151	128	37106										
TBK1	29110	broad.mit.edu	37	chr12	64875732	64875732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aactagtgatatacttcaccGaatggtaattcatgtttttt	6	6	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:64875732G>A	uc001ssc.1	+	8	985	c.923G>A	c.(922-924)CGA>CAA	p.R308Q		NM_013254	NP_037386	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	308	Protein kinase.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)		ATACTTCACCGAATGGTAATT	0.348													0	0	0	0.058154	0	10	27										A	64875732	G	A	64875732	3	1	124	1	0	0	0	0	1	0	0	0	15634	1058	37	1	949	1	TBK1	12	64875732	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	7389988	64875732	68976163	129	37107										
VEZT	55591	broad.mit.edu	37	chr12	95656756	95656756	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttacaagaggatgtggagctGattgagctacttgatcccag	12	7	0	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr12:95656756G>T	uc001tdz.2	+	4	438	c.333G>T	c.(331-333)CTG>CTT	p.L111L	VEZT_uc009zsy.1_Intron|VEZT_uc001tdr.2_Intron|VEZT_uc001tds.2_Silent_p.L63L|VEZT_uc001tdt.2_Silent_p.L63L|VEZT_uc009zsz.1_Silent_p.L111L|VEZT_uc001tdv.2_Silent_p.L80L|VEZT_uc001tdw.1_Silent_p.L63L|VEZT_uc009zta.1_Silent_p.L63L	NM_017599	NP_060069	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane	111						acrosomal vesicle|adherens junction|integral to membrane|nucleus				ovary(1)	1						ATGTGGAGCTGATTGAGCTAC	0.453													1	0	9.45814e-24	0.074837	1.07221e-23	38	108										T	95656756	G	T	95656756	2	4	124	1	0	0	0	0	0	0	0	1	17153	1277	45	3		3	VEZT	12	95656756	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	30781024	95656756	38195139	130	37108										
RB1	5925	broad.mit.edu	37	chr13	49050981	49050981	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagatgaagcagatggaaggTaggaaccagttttgaatgtt	13	4	0	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr13:49050981T>C	uc001vcb.2	+	25	2829	c.2663_splice	c.e25+2	p.S888_splice		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGATGGAAGGTAGGAACCAGT	0.453		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.108266	0	25	74										C	49050981	T	C	49050981	5	2	124	1	0	0	0	0	0	0	1	0	13098	1652	57	5	2763	5	RB1	13	49050981	Splice_Site	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08		49050981	66118897	131	37109										
NALCN	259232	broad.mit.edu	37	chr13	101720314	101720314	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccatattatttgaaagtggcGaagatcattgtaacttaaaa	7	5	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr13:101720314G>A	uc001vox.1	-	39	4591	c.4402C>T	c.(4402-4404)CGC>TGC	p.R1468C		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1468	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAAAGTGGCGAAGATCATTG	0.363													0	0	0	0.009096	0	4	56										A	101720314	G	A	101720314	3	1	124	1	0	0	0	0	1	0	0	0	10148	1058	37	1	838	1	NALCN	13	101720314	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	52669333	101720314	13449564	132	37110										
TPP2	7174	broad.mit.edu	37	chr13	103249446	103249446	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acggtctcctgccgaagaagGagaccggagccgcctccttc	12	15	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr13:103249446G>A	uc001vpi.3	+	1	161	c.58G>A	c.(58-60)GAG>AAG	p.E20K		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	20					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCCGAAGAAGGAGACCGGAGC	0.677													0	0	0	0.069234	0	10	29										A	103249446	G	A	103249446	3	1	124	1	0	0	0	0	1	0	0	0	16409	1175	41	1	60	1	TPP2	13	103249446	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1529132	103249446	11920432	133	37111										
ZNF828	283489	broad.mit.edu	37	chr13	115089871	115089871	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acctgcctctgtttcttctcCtgaacctccaaaatcagtcc	4	16	4	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr13:115089871C>T	uc010ahb.2	+	3	883	c.554C>T	c.(553-555)CCT>CTT	p.P185L	ZNF828_uc001vuv.2_Missense_Mutation_p.P185L|ZNF828_uc010tko.1_Missense_Mutation_p.P185L	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	185	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		GTTTCTTCTCCTGAACCTCCA	0.507													0	0	0	0.11126	0	42	156										T	115089871	C	T	115089871	3	4	124	1	0	0	0	0	1	0	0	0	18178	681	24	2	556	2	ZNF828	13	115089871	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	11840425	115089871	80007	134	37112										
C14orf101	54916	broad.mit.edu	37	chr14	57052563	57052563	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cttttggttcaattgcctacCgcgtcaatcttctctgtggc	8	12	4	0	rs144727961	by1000genomes	TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr14:57052563C>T	uc001xcm.2	+	3	399	c.277C>T	c.(277-279)CGC>TGC	p.R93C	C14orf101_uc001xcj.2_RNA|C14orf101_uc001xck.2_Missense_Mutation_p.R93C|C14orf101_uc010aot.1_Missense_Mutation_p.R93C|C14orf101_uc001xcl.1_RNA|C14orf101_uc001xcn.2_RNA|C14orf101_uc010trf.1_5'UTR	NM_017799	NP_060269	Q9NX78	CN101_HUMAN	hypothetical protein LOC54916	93						integral to membrane				breast(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(311;0.226)		AATTGCCTACCGCGTCAATCT	0.403													0	0	0	0.069288	0	21	50										T	57052563	C	T	57052563	3	4	124	1	0	0	0	0	1	0	0	0	1734	652	23	2	287	2	C14orf101	14	57052563	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		57052563	50296977	135	37113										
ALKBH1	8846	broad.mit.edu	37	chr14	78140190	78140190	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tatcctggcccgttttacttCgctattctggtcatccagat	7	12	2	1	rs146924402	byFrequency	TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr14:78140190C>T	uc001xuc.1	-	6	1144	c.1135G>A	c.(1135-1137)GAA>AAA	p.E379K	ALKBH1_uc001xud.1_RNA	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	379					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CGTTTTACTTCGCTATTCTGG	0.463													0	0	0	0.099896	0	27	44										T	78140190	C	T	78140190	3	4	124	1	0	0	0	0	1	0	0	0	526	893	31	1	38	1	ALKBH1	14	78140190	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	21087627	78140190	29209350	136	37114										
CDC42BPB	9578	broad.mit.edu	37	chr14	103426018	103426018	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agtgttgaaatactcaaaaaTggaatcctgaaaatctggaa	8	5	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr14:103426018T>C	uc001ymi.1	-	21	3083	c.2851A>G	c.(2851-2853)ATT>GTT	p.I951V	CDC42BPB_uc001ymj.1_Missense_Mutation_p.I79V	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	951					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TACTCAAAAATGGAATCCTGA	0.333													0	0	0	0.038395	0	15	4										C	103426018	T	C	103426018	3	2	124	1	0	0	0	0	1	0	0	0	3073	1464	51	5	2352	5	CDC42BPB	14	103426018	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	25285828	103426018	3923522	137	37115										
HERC2	8924	broad.mit.edu	37	chr15	28456242	28456242	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agcgcccgacctgctttcagGatgtatagcttcaactgctg	10	12	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr15:28456242G>A	uc001zbj.2	-	44	7081	c.6975C>T	c.(6973-6975)ATC>ATT	p.I2325I		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2325					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTGCTTTCAGGATGTATAGCT	0.577													0	0	0	0.059317	0	30	48										A	28456242	G	A	28456242	2	1	124	1	0	0	0	0	0	0	0	1	7058	1164	41	1		1	HERC2	15	28456242	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		28456242	74075150	138	37116										
NARG2	79664	broad.mit.edu	37	chr15	60740312	60740312	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agctaggtattccgatgtatCttcaacatagtcctgaagtt	8	8	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr15:60740312C>G	uc002agp.2	-	11	2387	c.2152G>C	c.(2152-2154)GAT>CAT	p.D718H	NARG2_uc002ago.2_Missense_Mutation_p.D581H|NARG2_uc002agq.3_Intron	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	718						nucleus				ovary(1)|lung(1)	2						TCCGATGTATCTTCAACATAG	0.363													0	0	0	0.043863	0	20	36										G	60740312	C	G	60740312	3	3	124	1	0	0	0	0	1	0	0	0	10169	913	32	1	820	1	NARG2	15	60740312	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	32284070	60740312	41791080	139	37117										
CCDC78	124093	broad.mit.edu	37	chr16	775574	775574	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagtacccggctctccagccGaaggatctgtgggacaactg	12	13	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:775574G>A	uc002cjg.2	-	4	380	c.274C>T	c.(274-276)CGG>TGG	p.R92W	CCDC78_uc002cjf.2_5'Flank|CCDC78_uc002cji.3_Missense_Mutation_p.R166W|CCDC78_uc002cjj.3_Intron|CCDC78_uc002cjh.2_5'UTR|CCDC78_uc010uuo.1_Missense_Mutation_p.R92W|CCDC78_uc002cjk.2_Missense_Mutation_p.R92W|HAGHL_uc002cjl.1_5'Flank|HAGHL_uc002cjm.1_5'Flank|HAGHL_uc002cjn.1_5'Flank|HAGHL_uc002cjo.1_5'Flank|HAGHL_uc010uup.1_5'Flank	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	92	Potential.									central_nervous_system(1)	1		Hepatocellular(780;0.0218)				CTCTCCAGCCGAAGGATCTGT	0.677													0	0	0	0.09319	0	12	43										A	775574	G	A	775574	3	1	124	1	0	0	0	0	1	0	0	0	2852	1057	37	1	1086	1	CCDC78	16	775574	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		775574	89579179	140	37118										
CEMP1	752014	broad.mit.edu	37	chr16	2580885	2580885	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtgaggtgcagggatacccaCctctgccttgacggccgcgc	14	14	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:2580885C>T	uc002cqr.2	-	1	546	c.190G>A	c.(190-192)GTG>ATG	p.V64M	AMDHD2_uc010uwc.1_3'UTR|AMDHD2_uc010uwd.1_3'UTR	NM_001048212	NP_001041677	Q6PRD7	CEMP1_HUMAN	cementum protein 1	64						cytoplasm				skin(1)	1						GGGATACCCACCTCTGCCTTG	0.662													0	0	0	0.049695	0	17	45										T	2580885	C	T	2580885	3	4	124	1	0	0	0	0	1	0	0	0	3224	507	18	2	557	2	CEMP1	16	2580885	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1805311	2580885	87773868	141	37119										
ZSCAN10	84891	broad.mit.edu	37	chr16	3139654	3139654	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgtgggtcagcaggtggcggGcaaggctggcccggcgcaca	19	12	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:3139654G>A	uc002ctv.1	-	5	1704	c.1616C>T	c.(1615-1617)GCC>GTC	p.A539V	ZSCAN10_uc002cty.1_Missense_Mutation_p.A200V|ZSCAN10_uc002ctw.1_Missense_Mutation_p.A457V|ZSCAN10_uc002ctx.1_Missense_Mutation_p.A467V	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	539	C2H2-type 8.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CAGGTGGCGGGCAAGGCTGGC	0.706													0	0	0	0.014758	0	5	19										A	3139654	G	A	3139654	3	1	124	1	0	0	0	0	1	0	0	0	18224	1203	42	2	565	2	ZSCAN10	16	3139654	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	558769	3139654	87215099	142	37120										
OTOA	146183	broad.mit.edu	37	chr16	21696662	21696662	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctgccatgaaatgcctcttaGaagacaagaaggacggcttg	11	9	1	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:21696662G>C	uc002djh.2	+	6	380	c.379G>C	c.(379-381)GAA>CAA	p.E127Q	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.E48Q	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	127					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		ATGCCTCTTAGAAGACAAGAA	0.557													0	0	0	0.014758	0	5	56										C	21696662	G	C	21696662	3	2	124	1	0	0	0	0	1	0	0	0	11302	943	33	1	435	1	OTOA	16	21696662	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	18557008	21696662	68658091	143	37121										
ZKSCAN2	342357	broad.mit.edu	37	chr16	25258366	25258366	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctggggttctaaggaagccaCattctcgcaaccattcagcc	9	13	3	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:25258366C>T	uc002dod.3	-	5	1558	c.1151G>A	c.(1150-1152)TGT>TAT	p.C384Y	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.C180Y|ZKSCAN2_uc002doe.2_Missense_Mutation_p.C384Y	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	384					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		AAGGAAGCCACATTCTCGCAA	0.483													0	0	0	0.048971	0	94	72										T	25258366	C	T	25258366	3	4	124	1	0	0	0	0	1	0	0	0	17684	478	17	2	1764	2	ZKSCAN2	16	25258366	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	3561704	25258366	65096387	144	37122										
PYDC1	260434	broad.mit.edu	37	chr16	31228334	31228334	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cagcaccttcaggatggcctCgcgcttcgttcccatggctc	10	16	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:31228334C>T	uc002ebo.2	-	1	65	c.16G>A	c.(16-18)GAG>AAG	p.E6K	TRIM72_uc002ebn.1_Intron	NM_152901	NP_690865	Q8WXC3	PYDC1_HUMAN	pyrin domain containing 1	6	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding				0						AGGATGGCCTCGCGCTTCGTT	0.647													0	0	0	0.02938	0	5	49										T	31228334	C	T	31228334	3	4	124	1	0	0	0	0	1	0	0	0	12858	893	31	1	257	1	PYDC1	16	31228334	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	5969968	31228334	59126419	145	37123										
CIRH1A	84916	broad.mit.edu	37	chr16	69184784	69184784	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	taaagaattacgatgccgctCtccgaaaaatcacctttccc	5	13	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:69184784C>G	uc002ews.3	+	8	1075	c.979C>G	c.(979-981)CTC>GTC	p.L327V	CIRH1A_uc002ewr.2_Missense_Mutation_p.L327V|CIRH1A_uc002ewt.3_Missense_Mutation_p.L244V|CIRH1A_uc010cfi.2_Missense_Mutation_p.L244V|CIRH1A_uc010cfj.1_Missense_Mutation_p.L146V	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	327	WD 8.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CGATGCCGCTCTCCGAAAAAT	0.522													0	0	0	0.043863	0	19	51										G	69184784	C	G	69184784	3	3	124	1	0	0	0	0	1	0	0	0	3434	913	32	1	1005	1	CIRH1A	16	69184784	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	37956450	69184784	21169969	146	37124										
HYDIN	54768	broad.mit.edu	37	chr16	70841650	70841650	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cttcttgggccgcacagactCtccagcgcgaatggtgaagg	13	12	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:70841650C>T	uc002ezr.2	-	86	15324	c.15196G>A	c.(15196-15198)GAG>AAG	p.E5066K	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	5067										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CGCACAGACTCTCCAGCGCGA	0.512													0	0	0	0.108266	0	28	91										T	70841650	C	T	70841650	3	4	124	1	0	0	0	0	1	0	0	0	7467	922	32	1	170	1	HYDIN	16	70841650	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1656866	70841650	19513103	147	37125										
PHLPP2	23035	broad.mit.edu	37	chr16	71682799	71682799	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gcccagtggggcagtcatagTgctgtgtcgaactcctccgg	14	12	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr16:71682799T>A	uc002fax.2	-	18	3972	c.3966A>T	c.(3964-3966)GCA>GCT	p.A1322A	PHLPP2_uc002fav.2_Intron|PHLPP2_uc010cgf.2_Silent_p.A1255A	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	1322						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						GCAGTCATAGTGCTGTGTCGA	0.542													0	0	0	0.048971	0	52	28										A	71682799	T	A	71682799	2	1	124	1	0	0	0	0	0	0	0	1	11855	1683	59	5		5	PHLPP2	16	71682799	Silent	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	841149	71682799	18671954	148	37126										
OR1A1	8383	broad.mit.edu	37	chr17	3119784	3119784	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aatcctttcatctacagtctGagaaatcgggacatgaaggc	9	9	3	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:3119784G>A	uc010vrc.1	+	1	870	c.870G>A	c.(868-870)CTG>CTA	p.L290L		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCTACAGTCTGAGAAATCGGG	0.463													0	0	0	0.080422	0	38	104										A	3119784	G	A	3119784	2	1	124	1	0	0	0	0	0	0	0	1	10949	1277	45	1		1	OR1A1	17	3119784	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		3119784	78075426	149	37127										
PLD2	5338	broad.mit.edu	37	chr17	4721806	4721807	+	Frame_Shift_Ins	INS	-	-	A													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agacaggggtggtgttaccgINSagtctacgtgcttttgccct							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:4721806_4721807insA	uc002fzc.2	+	20	2128_2129	c.2027_2028insA	c.(2026-2028)CGAfs	p.R676fs	PLD2_uc002fzd.2_Frame_Shift_Ins_p.R676fs	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	676	Catalytic.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	TGGTGTTACCGAGTCTACGTGC	0.599																		19	80	---	---								A	4721807	-	A	4721806	7	5	124	1	0	1	1	0	0	0	0	0	12046	1058	37	0	2101	0	PLD2	17	4721806	Frame_Shift_Ins	INS	-	TCGA-GV-A40G-01A-11D-A23M-08	1602022	4721806	76473404	150	37128										
CAMTA2	23125	broad.mit.edu	37	chr17	4883062	4883062	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggtcggagcagggatgcttgGagcttcgtcactgatgagtt	16	7	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:4883062G>A	uc002gah.1	-	9	1663	c.1555C>T	c.(1555-1557)CCA>TCA	p.P519S	CAMTA2_uc010cku.1_Missense_Mutation_p.P542S|CAMTA2_uc002gag.1_Missense_Mutation_p.P518S|CAMTA2_uc002gai.1_Missense_Mutation_p.P521S|CAMTA2_uc010ckv.1_Missense_Mutation_p.P166S|CAMTA2_uc010vsu.1_Missense_Mutation_p.P332S	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	519					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGGATGCTTGGAGCTTCGTCA	0.557													0	0	0	0.042209	0	45	109										A	4883062	G	A	4883062	3	1	124	1	0	0	0	0	1	0	0	0	2614	1174	41	1	2163	1	CAMTA2	17	4883062	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	161256	4883062	76312148	151	37129										
TP53	7157	broad.mit.edu	37	chr17	7577084	7577084	+	Missense_Mutation	SNP	T	T	A													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcttgcggagattctcttccTctgtgcgccggtctctccca					rs121912667		TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:7577084T>A	uc002gim.2	-	8	1048	c.854A>T	c.(853-855)GAG>GTG	p.E285V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153V|TP53_uc010cng.1_Missense_Mutation_p.E153V|TP53_uc002gii.1_Missense_Mutation_p.E153V|TP53_uc010cnh.1_Missense_Mutation_p.E285V|TP53_uc010cni.1_Missense_Mutation_p.E285V|TP53_uc002gij.2_Missense_Mutation_p.E285V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATTCTCTTCCTCTGTGCGCCG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.034045	0	30	36										A	7577084	T	A	7577084	3	1	124	1	0	0	0	0	1	0	0	0	16378	1551	54	5	432	5	TP53	17	7577084	Missense_Mutation	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	2694022	7577084	73618126	152	37130	193	2								
TP53	7157	broad.mit.edu	37	chr17	7577094	7577094	+	Missense_Mutation	SNP	G	G	A													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	attctcttcctctgtgcgccGgtctctcccaggacaggcac					rs28934574		TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.062417	0	23	31										A	7577094	G	A	7577094	3	1	124	1	0	0	0	0	1	0	0	0	16378	1115	39	2	442	2	TP53	17	7577094	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	10	7577094	73618116	153	37131	193	2								
RPL26	6154	broad.mit.edu	37	chr17	8285552	8285552	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gggaagacataatcttccttCgaatgtgggaaggtgcattg	13	6	1	1	rs11542516		TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:8285552C>T	uc002glh.1	-	2	173	c.77G>A	c.(76-78)CGA>CAA	p.R26Q		NM_000987	NP_000978	P61254	RL26_HUMAN	ribosomal protein L26	26					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						AATCTTCCTTCGAATGTGGGA	0.418													0	0	0	0.069234	0	11	36										T	8285552	C	T	8285552	3	4	124	1	0	0	0	0	1	0	0	0	13573	884	31	1	372	1	RPL26	17	8285552	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	708458	8285552	72909658	154	37132										
SUPT6H	6830	broad.mit.edu	37	chr17	27011886	27011886	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	caccctgtgttctgcgccctGgtcaatggtgaaggagaagt	13	10	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:27011886G>T	uc002hby.2	+	19	2484	c.2394G>T	c.(2392-2394)CTG>CTT	p.L798L	SUPT6H_uc010crt.2_Silent_p.L798L	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	798					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TCTGCGCCCTGGTCAATGGTG	0.453													1	0	7.41877e-09	0.062417	7.90051e-09	21	46										T	27011886	G	T	27011886	2	4	124	1	0	0	0	0	0	0	0	1	15397	1335	47	4		4	SUPT6H	17	27011886	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	18726334	27011886	54183324	155	37133										
PROCA1	147011	broad.mit.edu	37	chr17	27031334	27031334	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggctcactcaccagccatacCggaatcgctccacatgctcc	7	18	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:27031334C>T	uc002hcb.3	-	4	556	c.353G>A	c.(352-354)CGG>CAG	p.R118Q	PROCA1_uc010crv.2_Missense_Mutation_p.R44Q|PROCA1_uc002hca.1_Missense_Mutation_p.R116Q	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	144					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					CCAGCCATACCGGAATCGCTC	0.642													0	0	0	0.048971	0	50	243										T	27031334	C	T	27031334	3	4	124	1	0	0	0	0	1	0	0	0	12546	652	23	2	671	2	PROCA1	17	27031334	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	19448	27031334	54163876	156	37134										
ABHD15	116236	broad.mit.edu	37	chr17	27893269	27893269	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggacaggagcagcgccgagCccgagccttcgctcaccgcg	14	16	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:27893269C>G	uc002hed.1	-	1	780	c.716G>C	c.(715-717)GGC>GCC	p.G239A	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	239						extracellular region	carboxylesterase activity				0						CAGCGCCGAGCCCGAGCCTTC	0.697													0	0	0	0.069234	0	11	46										G	27893269	C	G	27893269	3	3	124	1	0	0	0	0	1	0	0	0	81	739	26	4	698	4	ABHD15	17	27893269	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	861935	27893269	53301941	157	37135										
PIGW	284098	broad.mit.edu	37	chr17	34894046	34894046	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	taaatgtagaagcagtatctCgaagaatggcaaatttagcc	9	6	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:34894046C>T	uc002hmy.1	+	2	1139	c.1096C>T	c.(1096-1098)CGA>TGA	p.R366*	MYO19_uc010wcy.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Nonsense_Mutation_p.R366*	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	366					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGCAGTATCTCGAAGAATGGC	0.343													0	0	0	0.009096	0	4	65										T	34894046	C	T	34894046	4	4	124	1	0	0	0	0	0	1	0	0	11902	876	31	1	1098	1	PIGW	17	34894046	Nonsense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	7000777	34894046	46301164	158	37136										
ERBB2	2064	broad.mit.edu	37	chr17	37866359	37866359	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgacgcgcactgtctgtgccGgtggctgtgcccgctgcaag	15	13	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:37866359G>T	uc002hso.2	+	6	902	c.664G>T	c.(664-666)GGT>TGT	p.G222C	ERBB2_uc002hsm.2_Missense_Mutation_p.G192C|ERBB2_uc010cwa.2_Missense_Mutation_p.G207C|ERBB2_uc002hsp.2_Missense_Mutation_p.G25C|ERBB2_uc010cwb.2_Missense_Mutation_p.G222C|ERBB2_uc010wek.1_Intron|ERBB2_uc002hsl.2_Missense_Mutation_p.G192C|ERBB2_uc002hsn.1_Missense_Mutation_p.G222C	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	222	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TGTCTGTGCCGGTGGCTGTGC	0.647		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			1	0	2.96211e-45	0.048971	3.40504e-45	101	47										T	37866359	G	T	37866359	3	4	124	1	0	0	0	0	1	0	0	0	5206	1116	39	4	686	4	ERBB2	17	37866359	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2972313	37866359	43328851	159	37137										
KRT38	8687	broad.mit.edu	37	chr17	39597029	39597029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gactcggttggcatgtgccaCgttggccaaaaggcacatgg	14	10	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:39597029C>T	uc002hwq.1	-	1	568	c.145G>A	c.(145-147)GTG>ATG	p.V49M		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	49	Head.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GCATGTGCCACGTTGGCCAAA	0.632													0	0	0	0.069234	0	10	120										T	39597029	C	T	39597029	3	4	124	1	0	0	0	0	1	0	0	0	8475	536	19	2	1253	2	KRT38	17	39597029	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1730670	39597029	41598181	160	37138										
NKIRAS2	28511	broad.mit.edu	37	chr17	40175690	40175690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggtcaccatcgtggtccttGgcaacaagtgtgacttacag	11	10	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:40175690G>A	uc002hyq.2	+	4	420	c.355G>A	c.(355-357)GGC>AGC	p.G119S	NKIRAS2_uc010wgd.1_Silent_p.L86L|NKIRAS2_uc002hyr.2_Missense_Mutation_p.G119S|NKIRAS2_uc002hys.2_Missense_Mutation_p.G119S|NKIRAS2_uc010wge.1_Missense_Mutation_p.G63S|NKIRAS2_uc002hyt.2_Missense_Mutation_p.G119S	NM_001001349	NP_001001349	Q9NYR9	KBRS2_HUMAN	NFKB inhibitor interacting Ras-like 2 isoform a	119	Small GTPase-like.				I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			ovary(1)	1		all_cancers(22;1.1e-05)|Breast(137;0.000143)|all_epithelial(22;0.000319)				CGTGGTCCTTGGCAACAAGTG	0.572													0	0	0	0.069288	0	18	81										A	40175690	G	A	40175690	3	1	124	1	0	0	0	0	1	0	0	0	10445	1348	47	2	365	2	NKIRAS2	17	40175690	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	578661	40175690	41019520	161	37139										
ITGA2B	3674	broad.mit.edu	37	chr17	42457993	42457993	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cacagccacctggttggcccCgtaagctcccacgatcaggt	10	16	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:42457993C>T	uc002igt.1	-	14	1446	c.1414G>A	c.(1414-1416)GGG>AGG	p.G472R	ITGA2B_uc002igu.1_5'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	472	Extracellular (Potential).|FG-GAP 7.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity	p.G472R(1)		ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	TGGTTGGCCCCGTAAGCTCCC	0.597													0	0	0	0.039052	0	40	59										T	42457993	C	T	42457993	3	4	124	1	0	0	0	0	1	0	0	0	7876	652	23	2	1773	2	ITGA2B	17	42457993	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	2282303	42457993	38737217	162	37140										
SPATA20	64847	broad.mit.edu	37	chr17	48628894	48628894	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttgatggtgtcaggctatgcTgtgactggggctgtcctggg	17	7	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:48628894T>C	uc002irf.2	+	12	1692	c.1551T>C	c.(1549-1551)GCT>GCC	p.A517A	SPATA20_uc002irc.2_Silent_p.A184A|SPATA20_uc002ire.2_Silent_p.A473A|SPATA20_uc002ird.2_Silent_p.A533A|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	517					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CAGGCTATGCTGTGACTGGGG	0.582													0	0	0	0.09319	0	12	82										C	48628894	T	C	48628894	2	2	124	1	0	0	0	0	0	0	0	1	15005	1567	55	5		5	SPATA20	17	48628894	Silent	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	6170901	48628894	32566316	163	37141										
C17orf71	55181	broad.mit.edu	37	chr17	57289841	57289841	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aaagcagccaattatgacttCtatcaggtagactctgaatt	7	8	3	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:57289841C>G	uc002ixi.2	+	2	1941	c.1899C>G	c.(1897-1899)TTC>TTG	p.F633L		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	633					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					ATTATGACTTCTATCAGGTAG	0.368													0	0	0	0.014758	0	4	108										G	57289841	C	G	57289841	3	3	124	1	0	0	0	0	1	0	0	0	1878	912	32	1	1905	1	C17orf71	17	57289841	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	8660947	57289841	23905369	164	37142										
EVPL	2125	broad.mit.edu	37	chr17	74011020	74011020	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggtccagctggtcccctacGgcgtggtagcggtcggtgag	17	11	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:74011020G>A	uc002jqi.2	-	17	2427	c.2199C>T	c.(2197-2199)GCC>GCT	p.A733A	EVPL_uc010wss.1_Silent_p.A755A|EVPL_uc010wst.1_Silent_p.A203A	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	733	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GGTCCCCTACGGCGTGGTAGC	0.542													0	0	0	0.009096	0	4	67										A	74011020	G	A	74011020	2	1	124	1	0	0	0	0	0	0	0	1	5292	1103	39	2		2	EVPL	17	74011020	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	16721179	74011020	7184190	165	37143										
CARD14	79092	broad.mit.edu	37	chr17	78180861	78180861	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtcatccacgtctctgtcaaCgagaagatggcaaagaagct	10	10	3	3	rs140536892		TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:78180861C>T	uc002jxw.1	+	20	2979	c.2784C>T	c.(2782-2784)AAC>AAT	p.N928N	CARD14_uc002jxt.1_RNA	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	928	Guanylate kinase-like.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TCTCTGTCAACGAGAAGATGG	0.612													0	0	0	0.11126	0	42	27										T	78180861	C	T	78180861	2	4	124	1	0	0	0	0	0	0	0	1	2646	535	19	2		2	CARD14	17	78180861	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	4169841	78180861	3014349	166	37144										
NPB	256933	broad.mit.edu	37	chr17	79860514	79860514	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggctgtgtgcgtccaggacGtcgccccaaacctgcagagg	14	13	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:79860514G>A	uc002kcd.2	+	2	350	c.268G>A	c.(268-270)GTC>ATC	p.V90I		NM_148896	NP_683694	Q8NG41	NPB_HUMAN	preproneuropeptide B precursor	90					neuropeptide signaling pathway	extracellular region					0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CGTCCAGGACGTCGCCCCAAA	0.726													0	0	0	0.021553	0	6	33										A	79860514	G	A	79860514	3	1	124	1	0	0	0	0	1	0	0	0	10567	1145	40	2	274	2	NPB	17	79860514	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1679653	79860514	1334696	167	37145										
HEXDC	284004	broad.mit.edu	37	chr17	80400084	80400084	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agtggagcaccctcgtgcagGagctggaggctgccctgcag	16	12	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr17:80400084G>A	uc002kew.2	+	12	1336	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K	HEXDC_uc002kev.3_Silent_p.R458R|HEXDC_uc010diq.2_Missense_Mutation_p.G431E|HEXDC_uc010wvm.1_RNA			Q8WVB3	HEXDC_HUMAN	SubName: Full=Hexosaminidase (Glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_c; SubName: Full=Hexosaminidase D;	429					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			ovary(1)|skin(1)	2	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CCTCGTGCAGGAGCTGGAGGC	0.642													0	0	0	0.020292	0	13	57										A	80400084	G	A	80400084	3	1	124	1	0	0	0	0	1	0	0	0	7075	1165	41	1	1416	1	HEXDC	17	80400084	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	539570	80400084	795126	168	37146										
AP3D1	8943	broad.mit.edu	37	chr19	2111719	2111719	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgcgccattctgcaccggctCccccgctgcctcctcgctgc	9	22	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:2111719C>T	uc002luz.2	-	23	2933	c.2710G>A	c.(2710-2712)GAG>AAG	p.E904K	AP3D1_uc010dsv.2_5'Flank|AP3D1_uc002luy.2_Missense_Mutation_p.E863K|AP3D1_uc002lva.2_Missense_Mutation_p.E966K	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	904					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCACCGGCTCCCCCGCTGCC	0.498													0	0	0	0.009096	0	4	8										T	2111719	C	T	2111719	3	4	124	1	0	0	0	0	1	0	0	0	746	864	30	1	783	1	AP3D1	19	2111719	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		2111719	57017264	169	37147										
XAB2	56949	broad.mit.edu	37	chr19	7684884	7684884	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gggctggtcacgctccgcctCagccgccagctgctctgccc	12	19	3	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:7684884C>T	uc002mgx.2	-	17	2370	c.2344G>A	c.(2344-2346)GAG>AAG	p.E782K		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	782					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						CGCTCCGCCTCAGCCGCCAGC	0.667								Direct_reversal_of_damage|NER					0	0	0	0.038395	0	16	63										T	7684884	C	T	7684884	3	4	124	1	0	0	0	0	1	0	0	0	17415	835	29	1	235	1	XAB2	19	7684884	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	5573165	7684884	51444099	170	37148										
CLEC4M	10332	broad.mit.edu	37	chr19	7831632	7831632	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccagcggaactggcacgactCcgtcaccgcctgccaggaag	12	16	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:7831632C>G	uc002mih.2	+	6	924	c.806C>G	c.(805-807)TCC>TGC	p.S269C	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.S225C|CLEC4M_uc010dvt.2_Missense_Mutation_p.S246C|CLEC4M_uc010dvs.2_Missense_Mutation_p.S268C|CLEC4M_uc010xjx.1_Missense_Mutation_p.S241C|CLEC4M_uc002mhz.2_Missense_Mutation_p.S200C|CLEC4M_uc002mic.2_Missense_Mutation_p.S264C|CLEC4M_uc002mia.2_Missense_Mutation_p.S156C	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	292	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						TGGCACGACTCCGTCACCGCC	0.597													0	0	0	0.055883	0	22	102										G	7831632	C	G	7831632	3	3	124	1	0	0	0	0	1	0	0	0	3518	855	30	1	914	1	CLEC4M	19	7831632	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	146748	7831632	51297351	171	37149										
DOCK6	57572	broad.mit.edu	37	chr19	11312572	11312572	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gatccccacccacctcctccCggtggcacacacggatgcga	9	19	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:11312572C>T	uc002mqs.3	-	44	5722	c.5681G>A	c.(5680-5682)CGG>CAG	p.R1894Q	DOCK6_uc002mqr.3_Missense_Mutation_p.R294Q|DOCK6_uc010xlq.1_Missense_Mutation_p.R1233Q	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1894	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CACCTCCTCCCGGTGGCACAC	0.677													0	0	0	0.009096	0	4	12										T	11312572	C	T	11312572	3	4	124	1	0	0	0	0	1	0	0	0	4691	652	23	2	482	2	DOCK6	19	11312572	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	3480940	11312572	47816411	172	37150										
ASNA1	439	broad.mit.edu	37	chr19	12856516	12856520	+	Frame_Shift_Del	DEL	GCGGG	GCGGG	-													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aacttccccaccatcgtggaGcggggcctgggccggcttat							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:12856516_12856520delGCGGG	uc002muv.2	+	4	566_570	c.552_556delGCGGG	c.(550-558)GAGCGGGGCfs	p.E184fs	ASNA1_uc002muw.2_Frame_Shift_Del_p.E183fs	NM_004317	NP_004308	O43681	ASNA_HUMAN	arsA arsenite transporter, ATP-binding, homolog	184_186					response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding	p.E184_L187del(1)		ovary(2)	2					Adenosine triphosphate(DB00171)	CCATCGTGGAGCGGGGCCTGGGCCG	0.644																		12	84	---	---								-	12856520	GCGGG	-	12856516	7	5	124	1	0	1	0	1	0	0	0	0	1047	962	34	0	566	0	ASNA1	19	12856516	Frame_Shift_Del	DEL	GCGGG	TCGA-GV-A40G-01A-11D-A23M-08	1543944	12856516	46272467	173	37151										
MYO9B	4650	broad.mit.edu	37	chr19	17295781	17295781	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aagaaaaagccaccaagcatCagcgcccagttccaggtagg	10	12	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:17295781C>T	uc010eak.2	+	17	2633	c.2481C>T	c.(2479-2481)ATC>ATT	p.I827I	MYO9B_uc002nfi.2_Silent_p.I827I|MYO9B_uc002nfj.1_Silent_p.I827I	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	827	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						CACCAAGCATCAGCGCCCAGT	0.557													0	0	0	0.080935	0	8	229										T	17295781	C	T	17295781	2	4	124	1	0	0	0	0	0	0	0	1	10085	816	29	1		1	MYO9B	19	17295781	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	4439265	17295781	41833202	174	37152										
KLHL26	55295	broad.mit.edu	37	chr19	18779242	18779242	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgccacttccgcgagctcacGgagatggaggtaggctgcag	15	12	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:18779242G>A	uc002njz.1	+	3	1062	c.1035G>A	c.(1033-1035)ACG>ACA	p.T345T		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	345	Kelch 1.									ovary(1)	1						GCGAGCTCACGGAGATGGAGG	0.682													0	0	0	0.062417	0	19	17										A	18779242	G	A	18779242	2	1	124	1	0	0	0	0	0	0	0	1	8381	1103	39	2		2	KLHL26	19	18779242	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1483461	18779242	40349741	175	37153										
ZNF492	57615	broad.mit.edu	37	chr19	22847804	22847805	+	Missense_Mutation	DNP	GG	GG	TT													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aacataaggtaattcatactGgagagaagccctacaaatat							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:22847804_22847805GG>TT	uc002nqw.3	+	4	1577_1578	c.1333_1334GG>TT	c.(1333-1335)GGA>TTA	p.G445L		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AATTCATACTGGAGAGAAGCCC	0.376													0	0	0	0.004672	0	26	47										TT	22847805	GG	TT	22847804	3	4	124	1	0	0	0	0	1	0	0	0	17940	1349	47	4	1343	4	ZNF492	19	22847804	Missense_Mutation	DNP	GG	TCGA-GV-A40G-01A-11D-A23M-08	4068562	22847804	36281179	176	37154										
ZNF792	126375	broad.mit.edu	37	chr19	35449114	35449114	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aactttcaggtgctgcctcaGattggacctctgcctgaagg	11	11	3	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:35449114G>A	uc002nxh.1	-	4	2032	c.1645C>T	c.(1645-1647)CTG>TTG	p.L549L		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	549	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCTGCCTCAGATTGGACCTC	0.527													0	0	0	0.105934	0	13	37										A	35449114	G	A	35449114	2	1	124	1	0	0	0	0	0	0	0	1	18161	933	33	1		1	ZNF792	19	35449114	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	12601310	35449114	23679869	177	37155										
CATSPERG	57828	broad.mit.edu	37	chr19	38845387	38845387	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ctggccagcgagtgcatcaaGaagctgtgccctgtgtattt	12	10	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:38845387G>C	uc002oih.3	+	9	1122	c.1035G>C	c.(1033-1035)AAG>AAC	p.K345N	CATSPERG_uc002oig.3_Missense_Mutation_p.K345N|CATSPERG_uc002oif.3_5'UTR|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	345	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						AGTGCATCAAGAAGCTGTGCC	0.562													0	0	0	0.058154	0	9	256										C	38845387	G	C	38845387	3	2	124	1	0	0	0	0	1	0	0	0	2692	933	33	1	1065	1	CATSPERG	19	38845387	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	3396273	38845387	20283596	178	37156										
CATSPERG	57828	broad.mit.edu	37	chr19	38845424	38845424	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atttccatagcaatggctctGagtacataatggccctcacc	7	12	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:38845424G>C	uc002oih.3	+	9	1159	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	CATSPERG_uc002oig.3_Missense_Mutation_p.E358Q|CATSPERG_uc002oif.3_5'UTR|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	358	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CAATGGCTCTGAGTACATAAT	0.557													0	0	0	0.069234	0	11	337										C	38845424	G	C	38845424	3	2	124	1	0	0	0	0	1	0	0	0	2692	1291	45	1	1102	1	CATSPERG	19	38845424	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	37	38845424	20283559	179	37157										
C19orf54	284325	broad.mit.edu	37	chr19	41248439	41248439	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cacccggccgtcagtggcccGtgagggcgagaagtccgtca	15	14	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:41248439G>A	uc002oou.1	-	6	1075	c.955C>T	c.(955-957)CGG>TGG	p.R319W	C19orf54_uc002oow.1_Missense_Mutation_p.R147W|C19orf54_uc002oox.1_RNA|C19orf54_uc002ooy.1_Intron|C19orf54_uc010xvs.1_Intron	NM_198476	NP_940878	Q5BKX5	CS054_HUMAN	hypothetical protein LOC284325	319											0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TCAGTGGCCCGTGAGGGCGAG	0.647													0	0	0	0.080935	0	12	13										A	41248439	G	A	41248439	3	1	124	1	0	0	0	0	1	0	0	0	1936	1144	40	2	104	2	C19orf54	19	41248439	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2403015	41248439	17880544	180	37158										
MEGF8	1954	broad.mit.edu	37	chr19	42866549	42866549	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tcaccaggcgtccaccccccGctgtaagtggtgtaccaact	9	16	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:42866549G>A	uc002otl.3	+	33	6292	c.5657G>A	c.(5656-5658)CGC>CAC	p.R1886H	MEGF8_uc002otm.3_Missense_Mutation_p.R1494H	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1953	Extracellular (Potential).|PSI 5.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TCCACCCCCCGCTGTAAGTGG	0.607													0	0	0	0.048971	0	74	95										A	42866549	G	A	42866549	3	1	124	1	0	0	0	0	1	0	0	0	9463	1087	38	2	5787	2	MEGF8	19	42866549	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1618110	42866549	16262434	181	37159										
IRGC	56269	broad.mit.edu	37	chr19	44222828	44222828	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgggtgacctcccccaggccGcctctcacctccaggagctg	11	19	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:44222828G>A	uc002oxh.2	+	2	265	c.118G>A	c.(118-120)GCC>ACC	p.A40T		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	40						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCCCCAGGCCGCCTCTCACCT	0.667													0	0	0	0.02938	0	6	116										A	44222828	G	A	44222828	3	1	124	1	0	0	0	0	1	0	0	0	7838	1087	38	2	120	2	IRGC	19	44222828	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1356279	44222828	14906155	182	37160										
ZFP112	7771	broad.mit.edu	37	chr19	44832186	44832186	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tatggtctttctccagaatgGacactctgatgactctgaag	9	9	4	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:44832186G>A	uc010ejj.2	-	5	2255	c.2142C>T	c.(2140-2142)GTC>GTT	p.V714V	ZFP112_uc002ozc.3_Silent_p.V708V|ZFP112_uc010xwy.1_Silent_p.V731V|ZFP112_uc010xwz.1_Silent_p.V713V	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	714	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CTCCAGAATGGACACTCTGAT	0.463													0	0	0	0.045705	0	32	104										A	44832186	G	A	44832186	2	1	124	1	0	0	0	0	0	0	0	1	17635	1161	41	1		1	ZFP112	19	44832186	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	609358	44832186	14296797	183	37161										
GEMIN7	79760	broad.mit.edu	37	chr19	45593632	45593632	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cacgttgcacgagggtgtgcGtgtggccgcccactttggag	16	11	0	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:45593632G>A	uc002pap.1	+	3	411	c.260G>A	c.(259-261)CGT>CAT	p.R87H	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.R87H|GEMIN7_uc002par.1_Missense_Mutation_p.R87H	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	87					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		GAGGGTGTGCGTGTGGCCGCC	0.642													0	0	0	0.0333	0	17	59										A	45593632	G	A	45593632	3	1	124	1	0	0	0	0	1	0	0	0	6333	1145	40	2	262	2	GEMIN7	19	45593632	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	761446	45593632	13535351	184	37162										
SAE1	10055	broad.mit.edu	37	chr19	47646784	47646784	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgggtgcttcttgtcggcttGaaaggacttggggctgaaat	15	7	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:47646784G>A	uc002pgc.2	+	2	188	c.132G>A	c.(130-132)TTG>TTA	p.L44L	SAE1_uc002pgd.2_Silent_p.L44L|SAE1_uc010ekx.2_Silent_p.L44L|SAE1_uc010ekw.2_RNA|SAE1_uc010xyk.1_5'UTR|SAE1_uc002pge.2_5'UTR	NM_016402	NP_057486	Q9UBE0	SAE1_HUMAN	SubName: Full=SUMO-1 activating enzyme subunit 1, isoform CRA_b; SubName: Full=cDNA, FLJ96708, Homo sapiens SUMO-1 activating enzyme subunit 1 (SAE1), mRNA;	44					protein sumoylation|protein ubiquitination	nucleus	ATP-dependent protein binding|enzyme activator activity|ligase activity|protein C-terminus binding|protein heterodimerization activity|ubiquitin activating enzyme activity			ovary(1)	1		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.00013)|OV - Ovarian serous cystadenocarcinoma(262;0.000146)|Epithelial(262;0.00697)|GBM - Glioblastoma multiforme(486;0.0278)		TTGTCGGCTTGAAAGGACTTG	0.488													0	0	0	0.024245	0	15	92										A	47646784	G	A	47646784	2	1	124	1	0	0	0	0	0	0	0	1	13805	1281	45	1		1	SAE1	19	47646784	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	2053152	47646784	11482199	185	37163										
GRIN2D	2906	broad.mit.edu	37	chr19	48919345	48919345	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtggacttctccgtccccttCgtggagaccggcatcagcgt	12	14	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:48919345C>T	uc002pjc.3	+	7	1756	c.1668C>T	c.(1666-1668)TTC>TTT	p.F556F		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	556	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CCGTCCCCTTCGTGGAGACCG	0.667													0	0	0	0.0333	0	17	93										T	48919345	C	T	48919345	2	4	124	1	0	0	0	0	0	0	0	1	6782	883	31	1		1	GRIN2D	19	48919345	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1272561	48919345	10209638	186	37164										
NR1H2	7376	broad.mit.edu	37	chr19	50881790	50881790	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cccctacaggcgtcctttctGaagaacagatccggaagaag	10	12	1	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:50881790G>A	uc010enw.2	+	6	760	c.484G>A	c.(484-486)GAA>AAA	p.E162K	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.E162K|NR1H2_uc002psa.3_Missense_Mutation_p.E65K	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	162					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CGTCCTTTCTGAAGAACAGAT	0.647													0	0	0	0.062417	0	21	98										A	50881790	G	A	50881790	3	1	124	1	0	0	0	0	1	0	0	0	10617	1291	45	1	498	1	NR1H2	19	50881790	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1962445	50881790	8247193	187	37165										
CD33	945	broad.mit.edu	37	chr19	51742831	51742831	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aacctcaagctgttcaggtgCcgcccctactgtggagatgg	12	12	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:51742831C>T	uc002pwa.2	+	7	1023	c.983C>T	c.(982-984)GCC>GTC	p.A328V	CD33_uc010eos.1_3'UTR|CD33_uc010eot.1_Missense_Mutation_p.A201V|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	328	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TGTTCAGGTGCCGCCCCTACT	0.517													0	0	0	0.09319	0	11	31										T	51742831	C	T	51742831	3	4	124	1	0	0	0	0	1	0	0	0	3005	739	26	2	1022	2	CD33	19	51742831	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	861041	51742831	7386152	188	37166										
ZNF468	90333	broad.mit.edu	37	chr19	53344325	53344325	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttcacatttgtaaggtttctCtccactatgaatcctcctat	4	11	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:53344325C>T	uc002qaf.2	-	4	1373	c.1222G>A	c.(1222-1224)GAG>AAG	p.E408K	ZNF468_uc002qae.2_Missense_Mutation_p.E355K	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		TAAGGTTTCTCTCCACTATGA	0.388													0	0	0	0.034045	0	29	110										T	53344325	C	T	53344325	3	4	124	1	0	0	0	0	1	0	0	0	17925	922	32	1	350	1	ZNF468	19	53344325	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1601494	53344325	5784658	189	37167										
NLRP12	91662	broad.mit.edu	37	chr19	54314478	54314478	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ttgacacattcccctaggcgCgcattgcggtcttccatgag	10	13	1	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:54314478C>A	uc002qch.3	-	3	655	c.435G>T	c.(433-435)GCG>GCT	p.A145A	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.A145A|NLRP12_uc002qcj.3_Silent_p.A145A|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.A145A	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	145					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCCCTAGGCGCGCATTGCGGT	0.567													1	0	3.69857e-22	0.037714	4.15455e-22	26	138										A	54314478	C	A	54314478	2	1	124	1	0	0	0	0	0	0	0	1	10474	755	27	4		4	NLRP12	19	54314478	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	970153	54314478	4814505	190	37168										
NLRP7	199713	broad.mit.edu	37	chr19	55451478	55451478	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ggctaggatgcttggaatgtCatcctgcaattcaggccagt	12	9	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:55451478C>T	uc002qih.3	-	4	785	c.709G>A	c.(709-711)GAC>AAC	p.D237N	NLRP7_uc002qig.3_Missense_Mutation_p.D237N|NLRP7_uc002qii.3_Missense_Mutation_p.D237N|NLRP7_uc010esk.2_Missense_Mutation_p.D237N|NLRP7_uc010esl.2_Missense_Mutation_p.D265N	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	237	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CTTGGAATGTCATCCTGCAAT	0.557													0	0	0	0.069456	0	35	127										T	55451478	C	T	55451478	3	4	124	1	0	0	0	0	1	0	0	0	10482	826	29	1	2436	1	NLRP7	19	55451478	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1137000	55451478	3677505	191	37169										
ZNF548	147694	broad.mit.edu	37	chr19	57910071	57910071	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aggggatgattggataccttCatttgggaagaaccacagag	13	6	1	3			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr19:57910071C>T	uc002qom.2	+	3	666	c.416C>T	c.(415-417)TCA>TTA	p.S139L	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.S142L	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGGATACCTTCATTTGGGAAG	0.478													0	0	0	0.062417	0	22	99										T	57910071	C	T	57910071	3	4	124	1	0	0	0	0	1	0	0	0	17977	838	29	1	466	1	ZNF548	19	57910071	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	2458593	57910071	1218912	192	37170										
XRN2	22803	broad.mit.edu	37	chr20	21309203	21309203	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aaatacattttcaggcaccaCgtgctaaaatgaaccagcag	7	10	1	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr20:21309203C>T	uc002wsf.1	+	4	417	c.322C>T	c.(322-324)CGT>TGT	p.R108C	XRN2_uc002wsg.1_Missense_Mutation_p.R32C|XRN2_uc010zsk.1_Missense_Mutation_p.R54C	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	108					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						TCAGGCACCACGTGCTAAAAT	0.388													0	0	0	0.038147	0	8	27										T	21309203	C	T	21309203	3	4	124	1	0	0	0	0	1	0	0	0	17457	536	19	2	336	2	XRN2	20	21309203	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		21309203	41716317	193	37171										
ZNF341	84905	broad.mit.edu	37	chr20	32336863	32336863	+	Frame_Shift_Del	DEL	C	C	-													0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gaccagcccatgccccagggCcccccacctgtgcaggtaag							TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr20:32336863delC	uc002wzy.2	+	4	494	c.474delC	c.(472-474)GGCfs	p.G158fs	ZNF341_uc002wzx.2_Frame_Shift_Del_p.G158fs|ZNF341_uc010geq.2_Frame_Shift_Del_p.G68fs|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	158	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGCCCCAGGGCCCCCCACCTG	0.537																		21	49	---	---								-	32336863	C	-	32336863	7	5	124	1	0	1	0	1	0	0	0	0	17854	726	26	0	488	0	ZNF341	20	32336863	Frame_Shift_Del	DEL	C	TCGA-GV-A40G-01A-11D-A23M-08	11027660	32336863	30688657	194	37172										
SERINC3	10955	broad.mit.edu	37	chr20	43138622	43138622	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atctaccagcagcaccagctGaatgaggatgaagagggcgg	14	9	1	4			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr20:43138622G>A	uc002xme.2	-	5	657	c.523C>T	c.(523-525)CAG>TAG	p.Q175*	SERINC3_uc002xmf.1_Nonsense_Mutation_p.Q175*|SERINC3_uc010ggs.1_Nonsense_Mutation_p.Q168*|SERINC3_uc010zwp.1_Nonsense_Mutation_p.Q120*	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	175	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGCACCAGCTGAATGAGGATG	0.433													0	0	0	0.020292	0	15	664										A	43138622	G	A	43138622	4	1	124	1	0	0	0	0	0	1	0	0	14081	1299	45	1	922	1	SERINC3	20	43138622	Nonsense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	10801759	43138622	19886898	195	37173										
CD40	958	broad.mit.edu	37	chr20	44756829	44756829	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	atccccatcatcttcgggatCctgtttgccatcctcttggt	7	14	3	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr20:44756829C>A	uc002xrg.1	+	7	689	c.612C>A	c.(610-612)ATC>ATA	p.I204I	CD40_uc002xrh.1_Missense_Mutation_p.P184T|CD40_uc002xri.1_Missense_Mutation_p.P218T|CD40_uc002xrj.1_RNA|CD40_uc002xrk.1_RNA|CD40_uc002xrl.1_RNA	NM_001250	NP_001241	P25942	TNR5_HUMAN	CD40 antigen isoform 1 precursor	204	Helical; (Potential).				B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			lung(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCTTCGGGATCCTGTTTGCCA	0.572									Immune_Deficiency_with_Hyper-IgM		OREG0025991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	9.16793e-09	0.0333	9.72117e-09	17	85										A	44756829	C	A	44756829	2	1	124	1	0	0	0	0	0	0	0	1	3015	855	30	3		3	CD40	20	44756829	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	1618207	44756829	18268691	196	37174										
COL20A1	57642	broad.mit.edu	37	chr20	61943386	61943386	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agggtcacctatgtgtccagCgagggtggacactcggggca	16	10	1	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr20:61943386C>T	uc011aau.1	+	14	1882	c.1782C>T	c.(1780-1782)AGC>AGT	p.S594S	COL20A1_uc011aav.1_Silent_p.S415S	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	594	Fibronectin type-III 4.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					ATGTGTCCAGCGAGGGTGGAC	0.677													0	0	0	0.069234	0	11	28										T	61943386	C	T	61943386	2	4	124	1	0	0	0	0	0	0	0	1	3679	767	27	2		2	COL20A1	20	61943386	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	17186557	61943386	1082134	197	37175										
GABPA	2551	broad.mit.edu	37	chr21	27141436	27141436	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	agttgaaccgtttggtcacaGaatgtgaacagaagaaactt	10	6	1	5			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr21:27141436G>A	uc002ylx.3	+	10	1785	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	GABPA_uc002yly.3_Missense_Mutation_p.E420K	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	420					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						TTTGGTCACAGAATGTGAACA	0.448													0	0	0	0.086207	0	38	102										A	27141436	G	A	27141436	3	1	124	1	0	0	0	0	1	0	0	0	6157	943	33	1	1292	1	GABPA	21	27141436	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		27141436	20988459	198	37176										
C2CD2	25966	broad.mit.edu	37	chr21	43321769	43321769	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gataatagtgcttttcttccGtggcgacttgagtttcagct	10	8	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr21:43321769G>A	uc002yzw.2	-	12	1764	c.1522C>T	c.(1522-1524)CGG>TGG	p.R508W	C2CD2_uc002yzs.2_Translation_Start_Site|C2CD2_uc002yzt.2_Missense_Mutation_p.R124W|C2CD2_uc002yzu.2_Missense_Mutation_p.R340W|C2CD2_uc002yzv.2_Missense_Mutation_p.R353W|C2CD2_uc002yzx.1_Missense_Mutation_p.R353W	NM_015500	NP_056315	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2 isoform	508						cytosol|extracellular region|nucleus				ovary(1)	1						CTTTTCTTCCGTGGCGACTTG	0.498													0	0	0	0.0918	0	22	56										A	43321769	G	A	43321769	3	1	124	1	0	0	0	0	1	0	0	0	2152	1144	40	2	580	2	C2CD2	21	43321769	Missense_Mutation	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	16180333	43321769	4808126	199	37177										
OSM	5008	broad.mit.edu	37	chr22	30659956	30659956	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	acccccttcctcagggcctgGtgggggctgtgtctccggct	14	15	2	0			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr22:30659956G>A	uc003ahb.2	-	3	727	c.675C>T	c.(673-675)CAC>CAT	p.H225H		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	225					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			TCAGGGCCTGGTGGGGGCTGT	0.657													0	0	0	0.038147	0	7	216										A	30659956	G	A	30659956	2	1	124	1	0	0	0	0	0	0	0	1	11291	1252	44	2		2	OSM	22	30659956	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08		30659956	20644610	200	37178										
C22orf24	25775	broad.mit.edu	37	chr22	32330184	32330184	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	tgatcttcctggctccctcaGggcctggtggcatcctgagg	13	13	2	2			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chr22:32330184G>A	uc003aly.2	-	3	570	c.403C>T	c.(403-405)CTG>TTG	p.L135L	C22orf24_uc003alx.2_RNA	NM_015372	NP_056187	Q9Y442	CV024_HUMAN	hypothetical protein LOC25775	135						integral to membrane				central_nervous_system(1)	1						GGCTCCCTCAGGGCCTGGTGG	0.373													0	0	0	0.038395	0	17	4										A	32330184	G	A	32330184	2	1	124	1	0	0	0	0	0	0	0	1	2138	991	35	2		2	C22orf24	22	32330184	Silent	SNP	G	TCGA-GV-A40G-01A-11D-A23M-08	1670228	32330184	18974382	201	37179										
DHRSX	207063	broad.mit.edu	37	chrX	2184836	2184836	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	gtaatgggtggcagaggagaCggtgaccaccctcgcactgt	15	10	0	3	rs149133886		TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chrX:2184836C>T	uc004cqf.3	-	5	590	c.541G>A	c.(541-543)GTC>ATC	p.V181I		NM_145177	NP_660160	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	181							binding|oxidoreductase activity				0		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCAGAGGAGACGGTGACCACC	0.547													0	0	0	0.048971	0	113	103										T	2184836	C	T	2184836	3	4	124	1	0	0	0	0	1	0	0	0	4499	536	19	2	463	2	DHRSX	23	2184836	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08		2184836	153085724	202	37180										
DHRSX	207063	broad.mit.edu	37	chrX	2343295	2343295	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	cgctgtagaatagccaatgcCatctgtccctcccgtcacta	7	15	2	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chrX:2343295C>A	uc004cqf.3	-	2	209	c.160G>T	c.(160-162)GGC>TGC	p.G54C		NM_145177	NP_660160	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	54	NAD or NADP (By similarity).						binding|oxidoreductase activity				0		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TAGCCAATGCCATCTGTCCCT	0.408													1	0	2.62258e-09	0.039052	2.80502e-09	44	57										A	2343295	C	A	2343295	3	1	124	1	0	0	0	0	1	0	0	0	4499	594	21	4	856	4	DHRSX	23	2343295	Missense_Mutation	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	158459	2343295	152927265	203	37181										
KIF4A	24137	broad.mit.edu	37	chrX	69626162	69626162	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	aaacatcttcctaaggatacCcttctatctccagactcttc	3	14	4	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chrX:69626162C>T	uc004dyg.2	+	27	3157	c.3030C>T	c.(3028-3030)ACC>ACT	p.T1010T	KIF4A_uc010nkw.2_Silent_p.T1010T	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	1010	Globular.|Interaction with PRC1.			QKHLPKDTLLSP -> RTLPRIPFYLQ (in Ref. 8; AAF86334).	anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						CTAAGGATACCCTTCTATCTC	0.443													0	0	0	0.042209	0	41	6										T	69626162	C	T	69626162	2	4	124	1	0	0	0	0	0	0	0	1	8303	610	22	2		2	KIF4A	23	69626162	Silent	SNP	C	TCGA-GV-A40G-01A-11D-A23M-08	67282867	69626162	85644398	204	37182										
COL4A6	1288	broad.mit.edu	37	chrX	107433641	107433641	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.230392156862745	47	1.51336312927694e-09	2.57993346399835	4.37448620082208	2.19748779877362	0.00034074130120774	0.0017037065060387	29	ccttttattcctttgaggccTaggtttccttttggaccttg	8	10	0	1			TCGA-GV-A40G-01A-11D-A23M-08	TCGA-GV-A40G-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	686d8ded-e77d-4a18-b51b-57b52bd6bce6	5cea95d6-c3e3-44ec-ac10-4f5ff302ee90	g.chrX:107433641T>A	uc004enw.3	-	20	1513	c.1410A>T	c.(1408-1410)CTA>CTT	p.L470L	COL4A6_uc004env.3_Silent_p.L469L|COL4A6_uc011msn.1_Silent_p.L469L|COL4A6_uc010npk.2_Silent_p.L469L	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	470	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CTTTGAGGCCTAGGTTTCCTT	0.453									Alport_syndrome_with_Diffuse_Leiomyomatosis				0	0	0	0.09836	0	42	14										A	107433641	T	A	107433641	2	1	124	1	0	0	0	0	0	0	0	1	3695	1509	53	5		5	COL4A6	23	107433641	Silent	SNP	T	TCGA-GV-A40G-01A-11D-A23M-08	37807479	107433641	47836919	205	37183										
PLCH2	9651	broad.mit.edu	37	chr1	2409941	2409941	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ggtgcatgggtgccatgcaaGaggggatgcagatggtgaag	19	5	0	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:2409941G>A	uc001aji.1	+	2	425	c.151G>A	c.(151-153)GAG>AAG	p.E51K	PLCH2_uc010nyz.1_5'Flank|PLCH2_uc009vle.1_5'Flank|PLCH2_uc001ajj.1_5'Flank|PLCH2_uc001ajk.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	51	PH.|Necessary for plasma membrane localization (By similarity).				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TGCCATGCAAGAGGGGATGCA	0.662													0	0	0	0.000308642	0	14	46										A	2409941	G	A	2409941	3	1	125	1	0	0	0	0	1	0	0	0	12038	943	33	1	157	1	PLCH2	1	2409941	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		2409941	246840680	1	37184										
CNR2	1269	broad.mit.edu	37	chr1	24201432	24201432	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tggcacctgcctgtcctggtGgccagacaagctggccacat	12	14	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:24201432G>A	uc001bif.2	-	2	803	c.676C>T	c.(676-678)CAC>TAC	p.H226Y		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	226	Cytoplasmic (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	CTGTCCTGGTGGCCAGACAAG	0.567													0	0	0	0.000422831	0	15	31										A	24201432	G	A	24201432	3	1	125	1	0	0	0	0	1	0	0	0	3632	1348	47	2	410	2	CNR2	1	24201432	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	21791491	24201432	225049189	2	37185										
ARID1A	8289	broad.mit.edu	37	chr1	27102153	27102153	+	Frame_Shift_Del	DEL	C	C	-													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gcattagataccatcaacatCctgctgtatgatgacaacag							TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:27102153delC	uc001bmv.1	+	19	5452	c.5079delC	c.(5077-5079)ATCfs	p.I1693fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.I1692fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.I1476fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.I539fs|ARID1A_uc009vsm.1_Frame_Shift_Del_p.I21fs|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1693					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCATCAACATCCTGCTGTATG	0.498			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC													27	59	---	---								-	27102153	C	-	27102153	7	5	125	1	0	1	0	1	0	0	0	0	913	845	30	0	5153	0	ARID1A	1	27102153	Frame_Shift_Del	DEL	C	TCGA-H4-A2HO-01A-11D-A17V-08	2900721	27102153	222148468	3	37186										
MAP7D1	55700	broad.mit.edu	37	chr1	36636771	36636771	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gggcctaggccagcccccccGcaggaagagtccccttcctc	11	19	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:36636771G>A	uc001bzz.2	+	2	462	c.246G>A	c.(244-246)CCG>CCA	p.P82P	MAP7D1_uc001caa.2_Silent_p.P82P|MAP7D1_uc001cab.2_Silent_p.P82P|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	82	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CAGCCCCCCCGCAGGAAGAGT	0.647													0	0	0	0.000339439	0	33	55										A	36636771	G	A	36636771	2	1	125	1	0	0	0	0	0	0	0	1	9267	1074	38	2		2	MAP7D1	1	36636771	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	9534618	36636771	212613850	4	37187										
HFM1	164045	broad.mit.edu	37	chr1	91778984	91778984	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttcagattttctttgcatagTgatttgatttccaaacctct	5	8	3	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:91778984T>C	uc001doa.3	-	30	3413	c.3313A>G	c.(3313-3315)ACT>GCT	p.T1105A	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.T784A|HFM1_uc001dob.3_Missense_Mutation_p.T293A|HFM1_uc010osv.1_Missense_Mutation_p.T789A	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1105							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CTTTGCATAGTGATTTGATTT	0.323													0	0	0	0.00111076	0	37	51										C	91778984	T	C	91778984	3	2	125	1	0	0	0	0	1	0	0	0	7083	1696	59	5	1034	5	HFM1	1	91778984	Missense_Mutation	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	55142213	91778984	157471637	5	37188										
LCE1E	353135	broad.mit.edu	37	chr1	152760035	152760035	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	caggcaccacaggtcccaccGtcacagaccccagagctctg	9	18	2	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:152760035G>A	uc001fan.2	+	2	313	c.260G>A	c.(259-261)CGT>CAT	p.R87H		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	87	Cys-rich.				keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGTCCCACCGTCACAGACCC	0.687													0	0	0	0.000442599	0	7	112										A	152760035	G	A	152760035	3	1	125	1	0	0	0	0	1	0	0	0	8663	1145	40	2	262	2	LCE1E	1	152760035	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	60981051	152760035	96490586	6	37189										
FCER1A	2205	broad.mit.edu	37	chr1	159275915	159275915	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aagctctcaagtactggtatGagaaccacaacatctccatt	6	11	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:159275915G>A	uc001ftq.2	+	5	568	c.469G>A	c.(469-471)GAG>AAG	p.E157K		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	157	Ig-like 2.|Extracellular (Potential).					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GTACTGGTATGAGAACCACAA	0.502													0	0	0	0.000274275	0	8	39										A	159275915	G	A	159275915	3	1	125	1	0	0	0	0	1	0	0	0	5774	1291	45	1	483	1	FCER1A	1	159275915	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	6515880	159275915	89974706	7	37190										
RC3H1	149041	broad.mit.edu	37	chr1	173907942	173907942	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agggtcctctgacaggttcaGagagctggtcttgtttgata	13	7	3	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:173907942G>C	uc001gju.3	-	19	3406	c.3319C>G	c.(3319-3321)CTG>GTG	p.L1107V	RC3H1_uc010pms.1_Missense_Mutation_p.L1098V|RC3H1_uc001gjv.2_Missense_Mutation_p.L1099V|RC3H1_uc010pmt.1_Missense_Mutation_p.L1108V	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	1107					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GACAGGTTCAGAGAGCTGGTC	0.443													0	0	0	0.000279167	0	31	65										C	173907942	G	C	173907942	3	2	125	1	0	0	0	0	1	0	0	0	13166	933	33	1	86	1	RC3H1	1	173907942	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	14632027	173907942	75342679	8	37191										
NUAK2	81788	broad.mit.edu	37	chr1	205273537	205273537	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agcctcctgctctcccactcGggtggcgtagccccagttga	11	16	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:205273537G>A	uc001hce.2	-	7	1055	c.928C>T	c.(928-930)CGA>TGA	p.R310*		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	310					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TCTCCCACTCGGGTGGCGTAG	0.692													0	0	0	0.000602214	0	5	18										A	205273537	G	A	205273537	4	1	125	1	0	0	0	0	0	1	0	0	10713	1124	39	2	962	2	NUAK2	1	205273537	Nonsense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	31365595	205273537	43977084	9	37192										
CABC1	56997	broad.mit.edu	37	chr1	227153387	227153388	+	Missense_Mutation	DNP	CG	CG	AT													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tccagctcagcgagcatgccCgggagcggaaggtgcctgtg					rs145350362		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:227153387_227153388CG>AT	uc001hqm.1	+	9	4023_4024	c.604_605CG>AT	c.(604-606)CGG>ATG	p.R202M	CABC1_uc001hqn.1_Missense_Mutation_p.R202M|CABC1_uc009xeq.1_Missense_Mutation_p.R150M|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_Translation_Start_Site	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	202					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CGAGCATGCCCGGGAGCGGAAG	0.639													0	0	0	6.4e-05	0	6	65										AT	227153388	CG	AT	227153387	3	1	125	1	0	0	0	0	1	0	0	0	2527	643	23	4	614	4	CABC1	1	227153387	Missense_Mutation	DNP	CG	TCGA-H4-A2HO-01A-11D-A17V-08	21879850	227153387	22097234	10	37193										
OBSCN	84033	broad.mit.edu	37	chr1	228433250	228433250	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tacaaggacgggaagaagctGagctccagctcaaaagtacg	12	9	1	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:228433250G>A	uc009xez.1	+	12	3662	c.3618G>A	c.(3616-3618)CTG>CTA	p.L1206L	OBSCN_uc001hsn.2_Silent_p.L1206L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1206	Ig-like 12.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAAGAAGCTGAGCTCCAGCT	0.602													0	0	0	0.000953801	0	36	77										A	228433250	G	A	228433250	2	1	125	1	0	0	0	0	0	0	0	1	10812	1277	45	1		1	OBSCN	1	228433250	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	1279863	228433250	20817371	11	37194										
PGBD5	79605	broad.mit.edu	37	chr1	230492669	230492669	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ggaaggcctgaaggcagagtCgaagctgttctgcagggagt	17	7	1	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr1:230492669C>T	uc010pwb.1	-	2	523	c.523G>A	c.(523-525)GAC>AAC	p.D175N	PGBD5_uc001htv.2_Missense_Mutation_p.D274N	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	175						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		AAGGCAGAGTCGAAGCTGTTC	0.612													0	0	0	0.000157383	0	6	102										T	230492669	C	T	230492669	3	4	125	1	0	0	0	0	1	0	0	0	11784	884	31	1	868	1	PGBD5	1	230492669	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	2059419	230492669	18757952	12	37195										
NBAS	51594	broad.mit.edu	37	chr2	15676631	15676631	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gctttatattctaaaaatatCaacccagcaatggcatagct	5	9	2	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:15676631C>G	uc002rcc.1	-	8	584	c.558G>C	c.(556-558)TTG>TTC	p.L186F	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	186										ovary(2)|liver(1)|skin(1)	4						CTAAAAATATCAACCCAGCAA	0.348													0	0	0	0.000781405	0	64	179										G	15676631	C	G	15676631	3	3	125	1	0	0	0	0	1	0	0	0	10186	825	29	1	6737	1	NBAS	2	15676631	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		15676631	227522742	13	37196										
MATN3	4148	broad.mit.edu	37	chr2	20202935	20202935	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gcctcacctgaacacgttttCttgtcggcattcaaggtgta	9	11	3	1	rs139419822	by1000genomes	TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:20202935C>T	uc002rdl.2	-	3	966	c.903G>A	c.(901-903)AAG>AAA	p.K301K	MATN3_uc010exu.1_Intron	NM_002381	NP_002372	O15232	MATN3_HUMAN	matrilin 3 precursor	301	EGF-like 1.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACACGTTTTCTTGTCGGCAT	0.527													0	0	0	0.000295444	0	20	45										T	20202935	C	T	20202935	2	4	125	1	0	0	0	0	0	0	0	1	9335	912	32	1		1	MATN3	2	20202935	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	4526304	20202935	222996438	14	37197										
TMEM214	54867	broad.mit.edu	37	chr2	27259978	27259978	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cttaccaagggcttcggcatGattggccccaaggacttctt	10	12	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:27259978G>T	uc002ria.3	+	8	1052	c.942G>T	c.(940-942)ATG>ATT	p.M314I	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.M269I	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	314						integral to membrane	protein binding				0						GCTTCGGCATGATTGGCCCCA	0.567													1	0	3.8128e-34	0.000781405	3.91141e-33	65	163										T	27259978	G	T	27259978	3	4	125	1	0	0	0	0	1	0	0	0	16134	1290	45	3	972	3	TMEM214	2	27259978	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	7057043	27259978	215939395	15	37198										
C2orf53	339779	broad.mit.edu	37	chr2	27361074	27361074	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttgagagggagggaggccctGatggggagagagaggctgta	21	4	0	4			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:27361074G>A	uc002rjb.2	-	3	704	c.124C>T	c.(124-126)CAG>TAG	p.Q42*		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	42	Pro-rich.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGAGGCCCTGATGGGGAGAG	0.627													0	0	0	0.00074312	0	19	30										A	27361074	G	A	27361074	4	1	125	1	0	0	0	0	0	1	0	0	2174	1299	45	1	1118	1	C2orf53	2	27361074	Nonsense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	101096	27361074	215838299	16	37199										
QPCT	25797	broad.mit.edu	37	chr2	37596833	37596834	+	Frame_Shift_Ins	INS	-	-	T													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tttttctccctcaggatttaINSttggtcttattggatttgat							TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:37596833_37596834insT	uc002rqg.2	+	5	851_852	c.729_730insT	c.(727-732)TTATTGfs	p.L243fs	QPCT_uc002rqh.2_Frame_Shift_Ins_p.L194fs	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	243_244					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				CTCAGGATTTATTGGTCTTATT	0.366																		31	70	---	---								T	37596834	-	T	37596833	7	5	125	1	0	1	1	0	0	0	0	0	12874	446	16	0	747	0	QPCT	2	37596833	Frame_Shift_Ins	INS	-	TCGA-H4-A2HO-01A-11D-A17V-08	10235759	37596833	205602540	17	37200										
ACYP2	98	broad.mit.edu	37	chr2	54531938	54531938	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	taattttagtattagatactAatagaagagaaaaattgtaa	6	1	0	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:54531938A>G	uc002rxq.3	+	4	725	c.299A>G	c.(298-300)TAA>TGA	p.*100*		NM_138448	NP_612457	P14621	ACYP2_HUMAN	acylphosphatase 2	100					phosphate metabolic process		acylphosphatase activity				0						ATTAGATACTAATAGAAGAGA	0.333													0	0	0	0.000151284	0	14	16										G	54531938	A	G	54531938	2	3	125	1	0	0	0	0	0	0	0	1	229	369	13	5		5	ACYP2	2	54531938	Silent	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08	16935105	54531938	188667435	18	37201										
PAPOLG	64895	broad.mit.edu	37	chr2	60996024	60996024	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agatggcattagaaacttaaGagtaagtatcctctggcatt	9	6	1	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:60996024G>A	uc002sai.2	+	5	668	c.437G>A	c.(436-438)AGA>AAA	p.R146K	PAPOLG_uc002saj.2_5'UTR|PAPOLG_uc002sak.2_5'UTR	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	146					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			AGAAACTTAAGAGTAAGTATC	0.284													0	0	0	0.00010058	0	12	15										A	60996024	G	A	60996024	3	1	125	1	0	0	0	0	1	0	0	0	11431	956	33	1	455	1	PAPOLG	2	60996024	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	6464086	60996024	182203349	19	37202										
EIF2AK3	9451	broad.mit.edu	37	chr2	88894996	88894996	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttttcacttacctttccactAtatgcactgagtccatatgt	4	11	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:88894996A>G	uc002stc.3	-	3	826	c.624T>C	c.(622-624)TAT>TAC	p.Y208Y		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	208	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						CCTTTCCACTATATGCACTGA	0.318													0	0	0	0.000566183	0	16	37										G	88894996	A	G	88894996	2	3	125	1	0	0	0	0	0	0	0	1	4998	456	16	5		5	EIF2AK3	2	88894996	Silent	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08	27898972	88894996	154304377	20	37203										
BOLL	66037	broad.mit.edu	37	chr2	198621229	198621229	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgcaatttccactggttgatAaataacctcagaaggttgca	8	8	1	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:198621229A>T	uc002uus.2	-	9	962	c.652T>A	c.(652-654)TAT>AAT	p.Y218N	uc002uup.2_Intron|BOLL_uc002uur.2_Missense_Mutation_p.Y224N|BOLL_uc002uut.2_Missense_Mutation_p.Y230N|BOLL_uc010zha.1_Missense_Mutation_p.Y109N|BOLL_uc002uuu.1_Missense_Mutation_p.Y246N	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	boule isoform 2	218					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2						ACTGGTTGATAAATAACCTCA	0.373													0	0	0	0.000274275	0	8	28										T	198621229	A	T	198621229	3	4	125	1	0	0	0	0	1	0	0	0	1487	362	13	5	211	5	BOLL	2	198621229	Missense_Mutation	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08	109726233	198621229	44578144	21	37204										
PIKFYVE	200576	broad.mit.edu	37	chr2	209189658	209189658	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gttttggaacgaatcagtcgAatgacccaaggtgatttagt	11	6	1	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:209189658A>T	uc002vcz.2	+	19	2513	c.2355A>T	c.(2353-2355)CGA>CGT	p.R785R	PIKFYVE_uc010fun.1_Silent_p.R466R|PIKFYVE_uc002vcy.1_Silent_p.R729R	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	785					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GAATCAGTCGAATGACCCAAG	0.343													0	0	0	0.00106085	0	25	58										T	209189658	A	T	209189658	2	4	125	1	0	0	0	0	0	0	0	1	11924	233	9	5		5	PIKFYVE	2	209189658	Silent	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08	10568429	209189658	34009715	22	37205										
CXCR2	3579	broad.mit.edu	37	chr2	219000386	219000386	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgatccaggagacctgtgagCgccgcaatcacatcgaccgg	12	13	1	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:219000386C>T	uc002vgz.1	+	4	1087	c.862C>T	c.(862-864)CGC>TGC	p.R288C	CXCR2_uc002vha.1_Missense_Mutation_p.R288C|CXCR2_uc002vhb.1_Missense_Mutation_p.R288C	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	288	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						GACCTGTGAGCGCCGCAATCA	0.592													0	0	0	8.12818e-05	0	7	95										T	219000386	C	T	219000386	3	4	125	1	0	0	0	0	1	0	0	0	4091	768	27	2	864	2	CXCR2	2	219000386	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	9810728	219000386	24198987	23	37206										
FAM134A	79137	broad.mit.edu	37	chr2	220047272	220047272	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agagacaccgccaaaaccccCtgatgctccacccctggggc	9	18	0	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:220047272C>T	uc002vjw.3	+	9	1689	c.1553C>T	c.(1552-1554)CCT>CTT	p.P518L	FAM134A_uc010fwc.2_Missense_Mutation_p.P311L|FAM134A_uc002vjx.2_Missense_Mutation_p.P276L	NM_024293	NP_077269	Q8NC44	F134A_HUMAN	hypothetical protein LOC79137	518						endoplasmic reticulum|integral to membrane				ovary(1)|central_nervous_system(1)	2		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAAAACCCCCTGATGCTCCA	0.607													0	0	0	0.000720815	0	27	66										T	220047272	C	T	220047272	3	4	125	1	0	0	0	0	1	0	0	0	5445	681	24	2	1587	2	FAM134A	2	220047272	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	1046886	220047272	23152101	24	37207										
TMEM198	130612	broad.mit.edu	37	chr2	220412380	220412380	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgggcatcgggctgctctgcGggctggtggccatgctagtg	18	10	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:220412380G>A	uc002vme.2	+	4	904	c.319G>A	c.(319-321)GGG>AGG	p.G107R	TMEM198_uc002vmf.2_Missense_Mutation_p.G107R	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	107	Helical; (Potential).|Leu-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GCTGCTCTGCGGGCTGGTGGC	0.687													0	0	0	0.000151284	0	14	125										A	220412380	G	A	220412380	3	1	125	1	0	0	0	0	1	0	0	0	16116	1116	39	2	325	2	TMEM198	2	220412380	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	365108	220412380	22786993	25	37208										
MTERFD2	130916	broad.mit.edu	37	chr2	242039054	242039054	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gagggaactcatgaccctctCtagctccaaggacccttgta	9	13	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr2:242039054C>G	uc002wan.1	-	1	857	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	MTERFD2_uc010zoj.1_Intron|MTERFD2_uc010zok.1_Missense_Mutation_p.E93Q	NM_182501	NP_872307	Q7Z6M4	MTER2_HUMAN	MTERF domain containing 2	93										ovary(1)	1		all_cancers(19;4.67e-31)|all_epithelial(40;8.67e-13)|Breast(86;0.000141)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;2.47e-32)|all cancers(36;1.79e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-14)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;2.81e-06)|Lung(119;0.000509)|LUSC - Lung squamous cell carcinoma(224;0.00442)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0886)		ATGACCCTCTCTAGCTCCAAG	0.507													0	0	0	0.000781405	0	44	82										G	242039054	C	G	242039054	3	3	125	1	0	0	0	0	1	0	0	0	9920	922	32	1	880	1	MTERFD2	2	242039054	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	21626674	242039054	1160319	26	37209										
SRGAP3	9901	broad.mit.edu	37	chr3	9032407	9032407	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttttgtgggggctgctggggCaggcagcagcccggggtggt	21	8	0	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:9032407C>T	uc003brf.1	-	21	3351	c.2675G>A	c.(2674-2676)TGC>TAC	p.C892Y	SRGAP3_uc003brg.1_Missense_Mutation_p.C868Y	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	892					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GCTGCTGGGGCAGGCAGCAGC	0.697			T	RAF1	pilocytic astrocytoma								0	0	0	0.00010058	0	12	18										T	9032407	C	T	9032407	3	4	125	1	0	0	0	0	1	0	0	0	15146	710	25	2	632	2	SRGAP3	3	9032407	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		9032407	188990023	27	37210										
ZNF167	55888	broad.mit.edu	37	chr3	44598778	44598778	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ccggcttcgggagctctgccGctggtggctcatgccagagg	16	13	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:44598778G>A	uc010hin.2	+	2	627	c.239G>A	c.(238-240)CGC>CAC	p.R80H	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Missense_Mutation_p.R80H|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.R80H|ZNF167_uc003cnk.2_Missense_Mutation_p.R80H	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	80	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		GAGCTCTGCCGCTGGTGGCTC	0.607													0	0	0	0.000151284	0	14	38										A	44598778	G	A	44598778	3	1	125	1	0	0	0	0	1	0	0	0	17738	1087	38	2	241	2	ZNF167	3	44598778	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	35566371	44598778	153423652	28	37211										
CACNA2D2	9254	broad.mit.edu	37	chr3	50414954	50414954	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agccacgtcaatgcccatcaCgcccaggatcagctggttct	9	15	4	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:50414954C>T	uc003daq.2	-	17	1608	c.1570G>A	c.(1570-1572)GTG>ATG	p.V524M	CACNA2D2_uc003dap.2_Missense_Mutation_p.V524M	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	524	Cache.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	ATGCCCATCACGCCCAGGATC	0.602													0	0	0	0.000673444	0	11	24										T	50414954	C	T	50414954	3	4	125	1	0	0	0	0	1	0	0	0	2549	536	19	2	1980	2	CACNA2D2	3	50414954	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	5816176	50414954	147607476	29	37212										
BOC	91653	broad.mit.edu	37	chr3	112998756	112998756	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tctcggccctacgtggtgtcGggctacagcggtcgcgtgta	15	12	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:112998756G>A	uc003dzx.2	+	13	2727	c.2106G>A	c.(2104-2106)TCG>TCA	p.S702S	BOC_uc003dzy.2_Silent_p.S702S|BOC_uc003dzz.2_Silent_p.S703S|BOC_uc003eab.2_Silent_p.S403S|BOC_uc003eac.2_Silent_p.S17S	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	702	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			ACGTGGTGTCGGGCTACAGCG	0.607													0	0	0	0.000589545	0	46	81										A	112998756	G	A	112998756	2	1	125	1	0	0	0	0	0	0	0	1	1481	1103	39	2		2	BOC	3	112998756	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	62583802	112998756	85023674	30	37213										
KIAA1407	57577	broad.mit.edu	37	chr3	113753924	113753924	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cactgagcctccaagaaggcCgattttttcagggtcttttc	9	11	2	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:113753924C>T	uc003eax.2	-	6	813	c.666G>A	c.(664-666)TCG>TCA	p.S222S	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Silent_p.S200S|KIAA1407_uc011bip.1_Silent_p.S209S	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	222	Potential.									ovary(2)	2						CCAAGAAGGCCGATTTTTTCA	0.423													0	0	0	0.000586117	0	26	69										T	113753924	C	T	113753924	2	4	125	1	0	0	0	0	0	0	0	1	8229	639	23	2		2	KIAA1407	3	113753924	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	755168	113753924	84268506	31	37214										
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.000422831	0	16	42										A	178936082	G	A	178936082	3	1	125	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1658	1	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	65182158	178936082	19086348	32	37215										
KLHL8	57563	broad.mit.edu	37	chr4	88099702	88099702	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aagaaccaactgtttttgttGatagaatagcattcaatact	6	6	1	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr4:88099702G>A	uc011cdb.1	-	5	1408	c.1023C>T	c.(1021-1023)ATC>ATT	p.I341I	KLHL8_uc003hql.1_Silent_p.I341I|KLHL8_uc003hqm.1_Silent_p.I265I|KLHL8_uc003hqn.1_Silent_p.I158I|KLHL8_uc010ikj.1_5'UTR	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	341	Kelch 1.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		TGTTTTTGTTGATAGAATAGC	0.428													0	0	0	0.000442599	0	8	64										A	88099702	G	A	88099702	2	1	125	1	0	0	0	0	0	0	0	1	8395	1280	45	1		1	KLHL8	4	88099702	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		88099702	103054574	33	37216										
FGA	2243	broad.mit.edu	37	chr4	155506820	155506820	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gagtctcctctgttgtaactCgtgctactagtaaattgttt	8	8	2	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr4:155506820C>G	uc003iod.1	-	5	1819	c.1761G>C	c.(1759-1761)ACG>ACC	p.T587T	FGA_uc003ioe.1_Silent_p.T587T|FGA_uc003iof.1_3'UTR	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	587	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TGTTGTAACTCGTGCTACTAG	0.433													0	0	0	0.000878237	0	27	49										G	155506820	C	G	155506820	2	3	125	1	0	0	0	0	0	0	0	1	5830	871	31	1		1	FGA	4	155506820	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	67407118	155506820	35647456	34	37217										
TLL1	7092	broad.mit.edu	37	chr4	166795194	166795194	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aacgaagaggataaaacagaGactatagattacaaggaccc	9	7	0	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr4:166795194G>C	uc003irh.1	+	1	785	c.138G>C	c.(136-138)GAG>GAC	p.E46D	TLL1_uc011cjn.1_Missense_Mutation_p.E46D|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	46					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATAAAACAGAGACTATAGATT	0.577													0	0	0	0.000781405	0	94	177										C	166795194	G	C	166795194	3	2	125	1	0	0	0	0	1	0	0	0	15942	933	33	1	140	1	TLL1	4	166795194	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	11288374	166795194	24359082	35	37218										
DNAH5	1767	broad.mit.edu	37	chr5	13814929	13814929	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ccagatggcatctactggacCatcaagaattatccagatat	7	10	2	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:13814929C>T	uc003jfd.2	-	43	7057	c.7015G>A	c.(7015-7017)GGT>AGT	p.G2339S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2339	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTACTGGACCATCAAGAATT	0.383									Kartagener_syndrome				0	0	0	0.000151284	0	13	24										T	13814929	C	T	13814929	3	4	125	1	0	0	0	0	1	0	0	0	4604	594	21	2	7007	2	DNAH5	5	13814929	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		13814929	167100331	36	37219										
SKIV2L2	23517	broad.mit.edu	37	chr5	54674240	54674240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gacagcagcttgccaaattgGgtaaagaaattgaagaatat	10	5	0	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:54674240G>A	uc003jpy.3	+	17	2175	c.1909G>A	c.(1909-1911)GGT>AGT	p.G637S	SKIV2L2_uc011cqi.1_Missense_Mutation_p.G536S	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	637					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGCCAAATTGGGTAAAGAAAT	0.308													0	0	0	0.000375601	0	23	69										A	54674240	G	A	54674240	3	1	125	1	0	0	0	0	1	0	0	0	14360	1232	43	2	1975	2	SKIV2L2	5	54674240	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	40859311	54674240	126241020	37	37220										
PCDHA7	56141	broad.mit.edu	37	chr5	140215322	140215322	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tggccgacgtgaacgacaacGccccggcgttcgcgcagccc	13	17	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:140215322G>A	uc003lhq.2	+	1	1354	c.1354G>A	c.(1354-1356)GCC>ACC	p.A452T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A452T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACAACGCCCCGGCGTT	0.677													0	0	0	0.000781405	0	50	99										A	140215322	G	A	140215322	3	1	125	1	0	0	0	0	1	0	0	0	11529	1087	38	2	1356	2	PCDHA7	5	140215322	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	85541082	140215322	40699938	38	37221										
PCDHA7	56141	broad.mit.edu	37	chr5	140215822	140215822	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	caaccggtggcggccggtgcGagcatcccgttccgcgtggg	17	14	0	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:140215822G>C	uc003lhq.2	+	1	1854	c.1854G>C	c.(1852-1854)GCG>GCC	p.A618A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.A618A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	618	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCCGGTGCGAGCATCCCGT	0.637													0	0	0	0.000589545	0	41	92										C	140215822	G	C	140215822	2	2	125	1	0	0	0	0	0	0	0	1	11529	1045	37	1		1	PCDHA7	5	140215822	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	500	140215822	40699438	39	37222										
PCDHGB6	56100	broad.mit.edu	37	chr5	140787909	140787909	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gctggccaagggctcggtggTggggaacctcgctaaggatc	17	10	0	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:140787909T>A	uc003lkj.1	+	1	140	c.140T>A	c.(139-141)GTG>GAG	p.V47E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.V47E	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	47	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTCGGTGGTGGGGAACCTC	0.592													0	0	0	0.000132079	0	20	55										A	140787909	T	A	140787909	3	1	125	1	0	0	0	0	1	0	0	0	11567	1696	59	5	142	5	PCDHGB6	5	140787909	Missense_Mutation	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	572087	140787909	40127351	40	37223										
DBN1	1627	broad.mit.edu	37	chr5	176885084	176885084	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tcccctccttctgggtggtcTcgccattggttagcaggtgg	13	12	2	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr5:176885084T>C	uc003mgy.2	-	12	1923	c.1751A>G	c.(1750-1752)GAG>GGG	p.E584G	DBN1_uc011dga.1_Missense_Mutation_p.E316G|DBN1_uc003mgx.2_Missense_Mutation_p.E586G|DBN1_uc010jkn.1_Missense_Mutation_p.E534G|DBN1_uc003mgz.1_Missense_Mutation_p.E567G	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	584					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGGTGGTCTCGCCATTGGT	0.682													0	0	0	0.000339439	0	31	88										C	176885084	T	C	176885084	3	2	125	1	0	0	0	0	1	0	0	0	4252	1551	54	5	210	5	DBN1	5	176885084	Missense_Mutation	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	36097175	176885084	4030176	41	37224										
HIVEP1	3096	broad.mit.edu	37	chr6	12124529	12124529	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aaacatcaaactccagctctAccaacgtttttcctgttcaa	3	13	3	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:12124529A>C	uc003nac.2	+	4	4680	c.4501A>C	c.(4501-4503)ACC>CCC	p.T1501P	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1501					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTCCAGCTCTACCAACGTTTT	0.438													0	0	0	0.00106085	0	27	40										C	12124529	A	C	12124529	3	2	125	1	0	0	0	0	1	0	0	0	7186	391	14	5	4511	5	HIVEP1	6	12124529	Missense_Mutation	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08		12124529	158990538	42	37225										
HIST1H2BG	8339	broad.mit.edu	37	chr6	26216573	26216573	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gctctccgggaagcagcagaCgcacggcggtctggatctcc	14	14	3	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:26216573C>T	uc003ngz.2	-	1	300	c.299G>A	c.(298-300)CGT>CAT	p.R100H	HIST1H2AE_uc003nha.1_5'Flank	NM_003518	NP_003509	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	100					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1		all_hematologic(11;0.196)				AAGCAGCAGACGCACGGCGGT	0.567													0	0	0	0.000878237	0	26	148										T	26216573	C	T	26216573	3	4	125	1	0	0	0	0	1	0	0	0	7146	536	19	2	85	2	HIST1H2BG	6	26216573	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	14092044	26216573	144898494	43	37226										
HLA-F	3134	broad.mit.edu	37	chr6	29694776	29694776	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gtcacagtgtcttgggccgcCggaaggtgggtgacatgtgg	18	8	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:29694776C>A	uc003nno.3	+	7	1277	c.1153C>A	c.(1153-1155)CGG>AGG	p.R385R	HLA-F_uc011dlx.1_Silent_p.R385R|HLA-F_uc011dly.1_RNA|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0						CTTGGGCCGCCGGAAGGTGGG	0.512													1	0	1.50039e-11	0.000229342	1.48789e-10	21	244										A	29694776	C	A	29694776	2	1	125	1	0	0	0	0	0	0	0	1	7211	643	23	4		4	HLA-F	6	29694776	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	3478203	29694776	141420291	44	37227										
HLA-C	3107	broad.mit.edu	37	chr6	31239532	31239532	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ccctctcggactcgcggcgtCgctgtcgaaccgcacgaact	11	17	1	0	rs41543115		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:31239532C>T	uc003nsy.2	-	2	194	c.187G>A	c.(187-189)GAC>AAC	p.D63N	HLA-C_uc011dnj.1_Missense_Mutation_p.D35N|HLA-C_uc003nsx.2_5'UTR|HLA-C_uc003nsz.2_Missense_Mutation_p.D63N|HLA-C_uc010jsl.2_Missense_Mutation_p.D63N|HLA-C_uc003nta.2_Missense_Mutation_p.D63N|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_5'UTR|HLA-B_uc003ntf.2_Intron	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	63	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						CTCGCGGCGTCGCTGTCGAAC	0.687													0	0	0	0.000781405	0	63	50										T	31239532	C	T	31239532	3	4	125	1	0	0	0	0	1	0	0	0	7197	884	31	1	941	1	HLA-C	6	31239532	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	1544756	31239532	139875535	45	37228										
HSPA1A	3303	broad.mit.edu	37	chr6	31785219	31785219	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gaggggctcaagggcaagatCagcgaggcggacaagaagaa	17	7	2	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:31785219C>T	uc003nxj.2	+	1	1929	c.1686C>T	c.(1684-1686)ATC>ATT	p.I562I	HSPA1L_uc003nxh.2_5'Flank|HSPA1L_uc010jte.2_5'Flank|HSPA1A_uc011doj.1_Silent_p.I325I|HSPA1A_uc003nxi.1_Silent_p.I397I|uc011dok.1_RNA	NM_005345	NP_005336	P08107	HSP71_HUMAN	heat shock 70kDa protein 1A	562					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			ovary(1)	1						AGGGCAAGATCAGCGAGGCGG	0.587													0	0	0	0.000781405	0	53	64										T	31785219	C	T	31785219	2	4	125	1	0	0	0	0	0	0	0	1	7408	816	29	1		1	HSPA1A	6	31785219	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	545687	31785219	139329848	46	37229										
EPHA7	2045	broad.mit.edu	37	chr6	93955099	93955099	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tatctttccatcttaatagcTtgtagccattctccaactga	4	11	3	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:93955099T>C	uc003poe.2	-	16	3040	c.2799A>G	c.(2797-2799)CAA>CAG	p.Q933Q	EPHA7_uc003pof.2_Silent_p.Q928Q|EPHA7_uc011eac.1_Silent_p.Q929Q	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	933	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TCTTAATAGCTTGTAGCCATT	0.378													0	0	0	0.000227799	0	29	78										C	93955099	T	C	93955099	2	2	125	1	0	0	0	0	0	0	0	1	5172	1606	56	5		5	EPHA7	6	93955099	Silent	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	62169880	93955099	77159968	47	37230										
HACE1	57531	broad.mit.edu	37	chr6	105225170	105225170	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aatgcaaatgttcatagaacCattcacagcgatctttaaaa	5	8	3	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr6:105225170C>T	uc003pqu.1	-	15	1866	c.1589G>A	c.(1588-1590)TGG>TAG	p.W530*	HACE1_uc010kcy.1_Nonsense_Mutation_p.W12*|HACE1_uc010kcz.1_Intron|HACE1_uc010kcx.1_5'UTR|HACE1_uc003pqt.1_Nonsense_Mutation_p.W183*	NM_020771	NP_065822	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing, E3	530					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			ovary(5)|lung(2)	7		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TTCATAGAACCATTCACAGCG	0.373													0	0	0	0.000781405	0	48	99										T	105225170	C	T	105225170	4	4	125	1	0	0	0	0	0	1	0	0	6940	595	21	2	1180	2	HACE1	6	105225170	Nonsense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	11270071	105225170	65889897	48	37231										
CREB5	9586	broad.mit.edu	37	chr7	28843821	28843821	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tttgttctgtttcagaggttGaaggctgcattgactcacca	10	8	3	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr7:28843821G>A	uc003szq.2	+	8	1098	c.708G>A	c.(706-708)TTG>TTA	p.L236L	CREB5_uc003szo.2_Silent_p.L203L|CREB5_uc003szr.2_Silent_p.L229L|CREB5_uc003szs.2_Silent_p.L97L	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	236					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						TTCAGAGGTTGAAGGCTGCAT	0.453													0	0	0	0.00058488	0	33	43										A	28843821	G	A	28843821	2	1	125	1	0	0	0	0	0	0	0	1	3860	1281	45	1		1	CREB5	7	28843821	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		28843821	130294842	49	37232										
ASB4	51666	broad.mit.edu	37	chr7	95157438	95157438	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tggaactgtgaccacgtgctCatgcacatgatgctggaagc	12	10	1	2	rs142833028		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr7:95157438C>T	uc011kij.1	+	3	801	c.801C>T	c.(799-801)CTC>CTT	p.L267L	ASB4_uc003unx.2_Silent_p.L267L	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	267	ANK 6.				intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			ACCACGTGCTCATGCACATGA	0.562											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000175454	0	22	42										T	95157438	C	T	95157438	2	4	125	1	0	0	0	0	0	0	0	1	1025	813	29	1		1	ASB4	7	95157438	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	66313617	95157438	63981225	50	37233										
DOCK4	9732	broad.mit.edu	37	chr7	111422965	111422965	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tttttgccatctacctctccCattttcatgcagtccctaaa	3	14	3	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr7:111422965C>T	uc003vfx.2	-	34	3782	c.3513G>A	c.(3511-3513)ATG>ATA	p.M1171I	DOCK4_uc011kml.1_Missense_Mutation_p.M52I|DOCK4_uc011kmm.1_Missense_Mutation_p.M78I|DOCK4_uc003vfw.2_Missense_Mutation_p.M621I|DOCK4_uc003vfy.2_Missense_Mutation_p.M1216I	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1171	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CTACCTCTCCCATTTTCATGC	0.373													0	0	0	0.000509022	0	41	108										T	111422965	C	T	111422965	3	4	125	1	0	0	0	0	1	0	0	0	4689	594	21	2	2463	2	DOCK4	7	111422965	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	16265527	111422965	47715698	51	37234										
TGS1	96764	broad.mit.edu	37	chr8	56711557	56711557	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ctcatgacaatgtgcacgacGcttccacaagtagtgattca	8	11	2	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr8:56711557G>A	uc003xsj.3	+	8	2014	c.1627G>A	c.(1627-1629)GCT>ACT	p.A543T	TGS1_uc010lyh.2_Missense_Mutation_p.A447T	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	543					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGTGCACGACGCTTCCACAAG	0.388													0	0	0	0.00047179	0	23	48										A	56711557	G	A	56711557	3	1	125	1	0	0	0	0	1	0	0	0	15834	1087	38	2	1657	2	TGS1	8	56711557	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		56711557	89652465	52	37235										
C8orf45	157777	broad.mit.edu	37	chr8	67786681	67786681	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	acctttaaaagctgctgaagTctttcaatcagtaagtcaaa	6	8	4	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr8:67786681T>C	uc003xwz.3	+	3	386	c.215T>C	c.(214-216)GTC>GCC	p.V72A	C8orf45_uc003xwv.2_Missense_Mutation_p.V72A|C8orf45_uc011lev.1_Missense_Mutation_p.V72A|C8orf45_uc011lew.1_Intron|C8orf45_uc011lex.1_5'UTR|C8orf45_uc003xwy.3_Missense_Mutation_p.V72A	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	72					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCTGCTGAAGTCTTTCAATCA	0.303													0	0	0	0.000279167	0	28	61										C	67786681	T	C	67786681	3	2	125	1	0	0	0	0	1	0	0	0	2430	1667	58	5	221	5	C8orf45	8	67786681	Missense_Mutation	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	11075124	67786681	78577341	53	37236										
CDKN2B	1030	broad.mit.edu	37	chr9	22008871	22008871	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	caggagctgtcgcaccttctCcactagtccccgcgccgcgg	11	18	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:22008871C>G	uc003zpo.2	-	1	442	c.82G>C	c.(82-84)GAG>CAG	p.E28Q	MTAP_uc003zpi.1_Intron|CDKN2BAS_uc010miw.1_Intron|CDKN2BAS_uc010mix.1_Intron|CDKN2BAS_uc003zpm.2_Intron|CDKN2B_uc003zpn.2_Missense_Mutation_p.E28Q	NM_004936	NP_004927	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B isoform 1	28	ANK 1; truncated.				cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CGCACCTTCTCCACTAGTCCC	0.716									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System		OREG0019127	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000274275	0	9	16										G	22008871	C	G	22008871	3	3	125	1	0	0	0	0	1	0	0	0	3164	864	30	1	423	1	CDKN2B	9	22008871	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		22008871	119204560	54	37237										
TLE4	7091	broad.mit.edu	37	chr9	82267521	82267521	+	Frame_Shift_Del	DEL	C	C	-													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	acagcagcaacaactccaggCccagcatttatcacatggac							TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:82267521delC	uc004ald.2	+	7	1232	c.383delC	c.(382-384)GCCfs	p.A128fs	TLE4_uc004alc.2_Frame_Shift_Del_p.A135fs|TLE4_uc010mpr.2_Frame_Shift_Del_p.A14fs|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Frame_Shift_Del_p.A103fs|TLE4_uc010mps.2_Frame_Shift_Del_p.A128fs|TLE4_uc004alf.2_Frame_Shift_Del_p.A74fs	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						CAACTCCAGGCCCAGCATTTA	0.532																		70	174	---	---								-	82267521	C	-	82267521	7	5	125	1	0	1	0	1	0	0	0	0	15938	739	26	0	430	0	TLE4	9	82267521	Frame_Shift_Del	DEL	C	TCGA-H4-A2HO-01A-11D-A17V-08	60258650	82267521	58945910	55	37238										
ASPN	54829	broad.mit.edu	37	chr9	95219645	95219645	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gttgcaggttgcatttcccaGtatttcaccgggttgttgaa	11	8	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:95219645G>T	uc004ase.1	-	8	1312	c.1068C>A	c.(1066-1068)TAC>TAA	p.Y356*	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ASPN_uc010mqy.1_3'UTR	NM_017680	NP_060150	Q9BXN1	ASPN_HUMAN	asporin precursor	356	LRR 10.				bone mineralization|negative regulation of tooth mineralization|negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	calcium ion binding				0						GCATTTCCCAGTATTTCACCG	0.378													1	0	4.35082e-09	0.000175454	4.24383e-08	20	39										T	95219645	G	T	95219645	4	4	125	1	0	0	0	0	0	1	0	0	1057	1024	36	4	78	4	ASPN	9	95219645	Nonsense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	12952124	95219645	45993786	56	37239										
STXBP1	6812	broad.mit.edu	37	chr9	130438119	130438119	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cagatgctgagggagagaagAtcaaggaccctatgcgagcc	14	9	1	4			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:130438119A>T	uc004brl.2	+	14	1344	c.1147A>T	c.(1147-1149)ATC>TTC	p.I383F	STXBP1_uc004brk.2_Missense_Mutation_p.I383F	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	383					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						GGGAGAGAAGATCAAGGACCC	0.488													0	0	0	0.000151284	0	12	40										T	130438119	A	T	130438119	3	4	125	1	0	0	0	0	1	0	0	0	15351	333	12	5	1201	5	STXBP1	9	130438119	Missense_Mutation	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08	35218474	130438119	10775312	57	37240										
CCBL1	883	broad.mit.edu	37	chr9	131600026	131600026	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ggtgcgtgatgtgaatttgcCggccagctccatggggtcca	15	10	0	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr9:131600026C>T	uc004bwh.2	-	6	690	c.505G>A	c.(505-507)GGC>AGC	p.G169S	CCBL1_uc004bwf.2_Missense_Mutation_p.G203S|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.G169S|CCBL1_uc004bwj.2_Missense_Mutation_p.G119S|CCBL1_uc011mbl.1_Missense_Mutation_p.G263S|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Intron	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	169					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	GTGAATTTGCCGGCCAGCTCC	0.622													0	0	0	0.000308642	0	13	127										T	131600026	C	T	131600026	3	4	125	1	0	0	0	0	1	0	0	0	2732	652	23	2	795	2	CCBL1	9	131600026	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	1161907	131600026	9613405	58	37241										
KIAA1217	56243	broad.mit.edu	37	chr10	24762637	24762637	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gtaacccctcaatgcaagcgGaaatgcatatggaacaatca	8	10	2	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:24762637G>A	uc001iru.3	+	6	1730	c.1327G>A	c.(1327-1329)GAA>AAA	p.E443K	KIAA1217_uc001irs.2_Missense_Mutation_p.E363K|KIAA1217_uc001irt.3_Missense_Mutation_p.E443K|KIAA1217_uc010qcy.1_Missense_Mutation_p.E443K|KIAA1217_uc010qcz.1_Missense_Mutation_p.E443K|KIAA1217_uc001irv.1_Missense_Mutation_p.E293K|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.E161K|KIAA1217_uc001irz.2_Missense_Mutation_p.E161K|KIAA1217_uc001irx.2_Missense_Mutation_p.E161K|KIAA1217_uc001iry.2_Missense_Mutation_p.E161K	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	443					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AATGCAAGCGGAAATGCATAT	0.517													0	0	0	0.00106085	0	28	40										A	24762637	G	A	24762637	3	1	125	1	0	0	0	0	1	0	0	0	8216	1175	41	1	1349	1	KIAA1217	10	24762637	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		24762637	110772110	59	37242										
PARD3	56288	broad.mit.edu	37	chr10	34648183	34648183	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tccatggcatcttggtttgtCttgcccaacagggattctcc	9	12	3	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:34648183C>G	uc010qej.1	-	14	1959	c.1959G>C	c.(1957-1959)AAG>AAC	p.K653N	PARD3_uc010qek.1_Missense_Mutation_p.K653N|PARD3_uc010qel.1_Missense_Mutation_p.K653N|PARD3_uc010qem.1_Missense_Mutation_p.K640N|PARD3_uc010qen.1_Missense_Mutation_p.K640N|PARD3_uc010qeo.1_Missense_Mutation_p.K640N|PARD3_uc010qep.1_Missense_Mutation_p.K596N|PARD3_uc010qeq.1_Missense_Mutation_p.K596N|PARD3_uc001ixo.1_Missense_Mutation_p.K370N|PARD3_uc001ixp.1_Missense_Mutation_p.K518N|PARD3_uc001ixq.1_Missense_Mutation_p.K640N|PARD3_uc001ixr.1_Missense_Mutation_p.K653N|PARD3_uc001ixt.1_Missense_Mutation_p.K474N|PARD3_uc001ixu.1_Missense_Mutation_p.K596N|PARD3_uc001ixs.1_Missense_Mutation_p.K306N	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	653	PDZ 3.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				CTTGGTTTGTCTTGCCCAACA	0.413													0	0	0	0.000781405	0	43	85										G	34648183	C	G	34648183	3	3	125	1	0	0	0	0	1	0	0	0	11443	912	32	1	2194	1	PARD3	10	34648183	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	9885546	34648183	100886564	60	37243										
HIF1AN	55662	broad.mit.edu	37	chr10	102296389	102296389	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gagttcgttgagaaactgcaGgatatacagcagcgaggagg	15	6	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:102296389G>A	uc001krj.3	+	2	474	c.399G>A	c.(397-399)CAG>CAA	p.Q133Q		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	133	Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		AGAAACTGCAGGATATACAGC	0.398													0	0	0	0.000374591	0	39	119										A	102296389	G	A	102296389	2	1	125	1	0	0	0	0	0	0	0	1	7104	991	35	2		2	HIF1AN	10	102296389	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	67648206	102296389	33238358	61	37244										
PSTK	118672	broad.mit.edu	37	chr10	124740004	124740004	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tccccgggcagcatgaagacCgccgagaacatcagaggaac	12	13	1	4			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:124740004C>T	uc001lgy.1	+	1	449	c.9C>T	c.(7-9)ACC>ACT	p.T3T		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	3							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GCATGAAGACCGCCGAGAACA	0.701											OREG0020597	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978159	0	10	13										T	124740004	C	T	124740004	2	4	125	1	0	0	0	0	0	0	0	1	12720	639	23	2		2	PSTK	10	124740004	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	22443615	124740004	10794743	62	37245										
FAM175B	23172	broad.mit.edu	37	chr10	126523363	126523363	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tatcctggaagtggggctgaCcttcctcctccccaaagagc	10	14	0	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr10:126523363C>T	uc001lib.3	+	9	1116	c.1071C>T	c.(1069-1071)GAC>GAT	p.D357D		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	357						BRISC complex	polyubiquitin binding				0						GTGGGGCTGACCTTCCTCCTC	0.493													0	0	0	0.000157383	0	8	23										T	126523363	C	T	126523363	2	4	125	1	0	0	0	0	0	0	0	1	5498	506	18	2		2	FAM175B	10	126523363	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	1783359	126523363	9011384	63	37246										
FJX1	24147	broad.mit.edu	37	chr11	35640997	35640997	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ctgcgccccctccgggatgcCgggggtgagctggccaacct	15	16	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:35640997C>T	uc001mwh.2	+	1	1263	c.813C>T	c.(811-813)GCC>GCT	p.A271A		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	271						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				TCCGGGATGCCGGGGGTGAGC	0.677													0	0	0	0.00024832	0	4	33										T	35640997	C	T	35640997	2	4	125	1	0	0	0	0	0	0	0	1	5901	639	23	2		2	FJX1	11	35640997	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		35640997	99365519	64	37247										
OR5R1	219479	broad.mit.edu	37	chr11	56185064	56185064	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ataataaagatgtaggaggtGaggacaatggaagaggaaga	15	1	0	4			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:56185064G>T	uc010rji.1	-	1	645	c.645C>A	c.(643-645)CTC>CTA	p.L215L		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGTAGGAGGTGAGGACAATGG	0.468													1	0	2.70639e-06	0.000295444	2.5161e-05	22	40										T	56185064	G	T	56185064	2	4	125	1	0	0	0	0	0	0	0	1	11180	1277	45	3		3	OR5R1	11	56185064	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	20544067	56185064	78821452	65	37248										
TNKS1BP1	85456	broad.mit.edu	37	chr11	57077076	57077076	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tctctgcccgagtgccccatCcggcacgtgggcagtgctag	13	15	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:57077076C>G	uc001njr.2	-	5	3421	c.3109G>C	c.(3109-3111)GAT>CAT	p.D1037H	TNKS1BP1_uc001njs.2_Missense_Mutation_p.D1037H|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.D488H	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1037	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				AGTGCCCCATCCGGCACGTGG	0.637													0	0	0	0.000781405	0	45	106										G	57077076	C	G	57077076	3	3	125	1	0	0	0	0	1	0	0	0	16317	855	30	1	2104	1	TNKS1BP1	11	57077076	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	892012	57077076	77929440	66	37249										
SPTBN2	6712	broad.mit.edu	37	chr11	66468734	66468734	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgccttcttgccgtctgccaGacgccgaaactgctgccacc	9	17	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:66468734G>T	uc001ojd.2	-	16	2908	c.2836C>A	c.(2836-2838)CTG>ATG	p.L946M		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	946	Spectrin 6.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCGTCTGCCAGACGCCGAAAC	0.582													1	0	5.35267e-07	0.000958276	5.09574e-06	19	43										T	66468734	G	T	66468734	3	4	125	1	0	0	0	0	1	0	0	0	15119	933	33	3	4424	3	SPTBN2	11	66468734	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	9391658	66468734	68537782	67	37250										
MOGAT2	80168	broad.mit.edu	37	chr11	75438555	75438555	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cccatggagtcctggcagtcGgagcctttgccaacctgtgc	12	14	0	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:75438555G>A	uc010rru.1	+	3	346	c.346G>A	c.(346-348)GGA>AGA	p.G116R	MOGAT2_uc001oww.1_Missense_Mutation_p.G116R|MOGAT2_uc010rrv.1_Missense_Mutation_p.G34R	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	116	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					CCTGGCAGTCGGAGCCTTTGC	0.602													0	0	0	0.000566183	0	16	176										A	75438555	G	A	75438555	3	1	125	1	0	0	0	0	1	0	0	0	9695	1117	39	2	356	2	MOGAT2	11	75438555	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	8969821	75438555	59567961	68	37251										
INTS4	92105	broad.mit.edu	37	chr11	77605369	77605369	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ctacttcctgtaaaaattttTcacacatcccaaataagggg	5	10	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:77605369T>G	uc001oys.2	-	19	2283	c.2255A>C	c.(2254-2256)GAA>GCA	p.E752A	C11orf67_uc001oyp.2_Intron|C11orf67_uc001oyr.1_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	752					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TAAAAATTTTTCACACATCCC	0.353													0	0	0	0.000958276	0	19	25										G	77605369	T	G	77605369	3	3	125	1	0	0	0	0	1	0	0	0	7780	1783	62	5	656	5	INTS4	11	77605369	Missense_Mutation	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	2166814	77605369	57401147	69	37252										
C11orf53	341032	broad.mit.edu	37	chr11	111156561	111156561	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gggctcagtcatactcgctgCatgctctggaagatctgcac	11	12	4	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr11:111156561C>T	uc001plc.2	+	4	640	c.493C>T	c.(493-495)CAT>TAT	p.H165Y		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	165											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		ATACTCGCTGCATGCTCTGGA	0.617													0	0	0	0.000409698	0	33	66										T	111156561	C	T	111156561	3	4	125	1	0	0	0	0	1	0	0	0	1648	710	25	2	503	2	C11orf53	11	111156561	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	33551192	111156561	23849955	70	37253										
GYS2	2998	broad.mit.edu	37	chr12	21757466	21757466	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ctcctccacaggaagttcttCgacttcccactggggaagcc	9	15	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:21757466C>G	uc001rfb.2	-	1	316	c.61G>C	c.(61-63)GAA>CAA	p.E21Q		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	21					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						GGAAGTTCTTCGACTTCCCAC	0.493													0	0	0	0.000184323	0	29	54										G	21757466	C	G	21757466	3	3	125	1	0	0	0	0	1	0	0	0	6913	893	31	1	2114	1	GYS2	12	21757466	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		21757466	112094429	71	37254										
ADAMTS20	80070	broad.mit.edu	37	chr12	43771260	43771260	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aggcaccacagggcattcttGataaactataggccgaagtc	10	10	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:43771260G>C	uc010skx.1	-	32	4903	c.4903C>G	c.(4903-4905)CAA>GAA	p.Q1635E		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1635	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GGGCATTCTTGATAAACTATA	0.428													0	0	0	0.000978159	0	12	23										C	43771260	G	C	43771260	3	2	125	1	0	0	0	0	1	0	0	0	266	1299	45	1	860	1	ADAMTS20	12	43771260	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	22013794	43771260	90080635	72	37255										
ADAMTS20	80070	broad.mit.edu	37	chr12	43886428	43886428	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	catcaaaattaatgactggtCcttcctatgcaaaataagca	5	9	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:43886428C>A	uc010skx.1	-	6	956	c.956G>T	c.(955-957)GGA>GTA	p.G319V		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	319	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AATGACTGGTCCTTCCTATGC	0.363													1	0	4.68919e-08	0.000673444	4.50011e-07	9	42										A	43886428	C	A	43886428	3	1	125	1	0	0	0	0	1	0	0	0	266	855	30	3	4911	3	ADAMTS20	12	43886428	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	115168	43886428	89965467	73	37256										
PPFIA2	8499	broad.mit.edu	37	chr12	81688723	81688723	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgattccaatttctctctggAtctcagtgtcagataaagca	7	9	4	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:81688723A>G	uc001szo.1	-	24	2977	c.2816T>C	c.(2815-2817)ATC>ACC	p.I939T	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	865										ovary(3)|lung(2)|pancreas(1)	6						TTCTCTCTGGATCTCAGTGTC	0.488													0	0	0	0.00024832	0	4	22										G	81688723	A	G	81688723	3	3	125	1	0	0	0	0	1	0	0	0	12310	333	12	5	993	5	PPFIA2	12	81688723	Missense_Mutation	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08	37802295	81688723	52163172	74	37257										
PLEKHG7	440107	broad.mit.edu	37	chr12	93149620	93149620	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ggggaccttgaaggaaaagtGaagtggctggacaatttcca	14	6	0	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:93149620G>A	uc001tcj.2	+	7	740	c.510G>A	c.(508-510)GTG>GTA	p.V170V		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	170	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						AAGGAAAAGTGAAGTGGCTGG	0.383													0	0	0	0.00106085	0	27	65										A	93149620	G	A	93149620	2	1	125	1	0	0	0	0	0	0	0	1	12075	1277	45	1		1	PLEKHG7	12	93149620	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	11460897	93149620	40702275	75	37258										
CCDC63	160762	broad.mit.edu	37	chr12	111319049	111319049	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agctcaagtccttcctgctcGtcaagctgaatgatcgcaat	8	12	2	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr12:111319049G>A	uc001trv.1	+	7	997	c.802G>A	c.(802-804)GTC>ATC	p.V268I	CCDC63_uc009zvt.1_3'UTR|CCDC63_uc010sye.1_Missense_Mutation_p.V228I|CCDC63_uc001trw.1_Missense_Mutation_p.V183I	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	268	Potential.									skin(6)|ovary(1)|pancreas(1)	8						CTTCCTGCTCGTCAAGCTGAA	0.498													0	0	0	0.000978159	0	12	28										A	111319049	G	A	111319049	3	1	125	1	0	0	0	0	1	0	0	0	2834	1145	40	2	824	2	CCDC63	12	111319049	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	18169429	111319049	22532846	76	37259										
SNX6	58533	broad.mit.edu	37	chr14	35036931	35036931	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aactctgccagttccactaaAttttttctgaatgcagcaac	5	11	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr14:35036931A>T	uc001wsf.1	-	13	1172	c.1164T>A	c.(1162-1164)AAT>AAA	p.N388K	SNX6_uc001wse.1_Missense_Mutation_p.N260K|SNX6_uc010tpm.1_Missense_Mutation_p.N264K	NM_152233	NP_689419	Q9UNH7	SNX6_HUMAN	sorting nexin 6 isoform b	376					cell communication|intracellular protein transport|negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent|negative regulation of transforming growth factor beta receptor signaling pathway|retrograde transport, endosome to Golgi	cytoplasmic vesicle membrane|early endosome membrane|nucleus	phosphatidylinositol binding|protein homodimerization activity				0	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00199)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.0245)		GTTCCACTAAATTTTTTCTGA	0.269													0	0	0	0.000295444	0	21	46										T	35036931	A	T	35036931	3	4	125	1	0	0	0	0	1	0	0	0	14906	98	4	5	100	5	SNX6	14	35036931	Missense_Mutation	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08		35036931	72312609	77	37260										
MTHFD1	4522	broad.mit.edu	37	chr14	64921557	64921557	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	attcgcgacatccgcgccagCgttggggctggttttctgta	13	11	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr14:64921557C>T	uc001xhb.2	+	26	3069	c.2682C>T	c.(2680-2682)AGC>AGT	p.S894S	MTHFD1_uc010aqf.2_Silent_p.S950S|ZBTB25_uc001xhc.2_Intron	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	894	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCCGCGCCAGCGTTGGGGCTG	0.532													0	0	0	0.000319135	0	37	93										T	64921557	C	T	64921557	2	4	125	1	0	0	0	0	0	0	0	1	9927	767	27	2		2	MTHFD1	14	64921557	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	29884626	64921557	42427983	78	37261										
KIF26A	26153	broad.mit.edu	37	chr14	104641739	104641739	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	acggagctcaggccagccccGcccgagggggccggaagccc	16	17	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr14:104641739G>A	uc001yos.3	+	12	2614	c.2614G>A	c.(2614-2616)GCC>ACC	p.A872T		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	872					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GGCCAGCCCCGCCCGAGGGGG	0.711													0	0	0	0.000978159	0	10	16										A	104641739	G	A	104641739	3	1	125	1	0	0	0	0	1	0	0	0	8294	1087	38	2	2660	2	KIF26A	14	104641739	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	39720182	104641739	2707801	79	37262										
LRRC49	54839	broad.mit.edu	37	chr15	71302329	71302329	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgcagaaaataaatggaacaGaggtaagctaaaaactagat	9	4	0	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr15:71302329G>C	uc002asw.2	+	13	1838	c.1591G>C	c.(1591-1593)GAG>CAG	p.E531Q	LRRC49_uc002asu.2_Missense_Mutation_p.E521Q|LRRC49_uc002asx.2_Missense_Mutation_p.E487Q|LRRC49_uc010ukf.1_Missense_Mutation_p.E536Q|LRRC49_uc002asy.2_Missense_Mutation_p.E237Q|LRRC49_uc002asz.2_Missense_Mutation_p.E503Q	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	531						cytoplasm|microtubule				ovary(1)	1						AAATGGAACAGAGGTAAGCTA	0.299													0	0	0	0.000132079	0	19	39										C	71302329	G	C	71302329	3	2	125	1	0	0	0	0	1	0	0	0	9006	943	33	1	1641	1	LRRC49	15	71302329	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		71302329	31229063	80	37263										
MAN2C1	4123	broad.mit.edu	37	chr15	75651976	75651976	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cgtacctaggctgtgggcccCgcccggtttgggcagggcca	16	14	0	0	rs147452674		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr15:75651976C>A	uc002baf.2	-	16	1950	c.1933G>T	c.(1933-1935)GGG>TGG	p.G645W	MAN2C1_uc002bag.2_Missense_Mutation_p.G645W|MAN2C1_uc002bah.2_Missense_Mutation_p.G645W|MAN2C1_uc010bkk.2_Missense_Mutation_p.G546W|MAN2C1_uc010umi.1_Missense_Mutation_p.G427W	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	645					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CTGTGGGCCCCGCCCGGTTTG	0.647													1	0	2.94398e-08	0.000958276	2.84824e-07	16	36										A	75651976	C	A	75651976	3	1	125	1	0	0	0	0	1	0	0	0	9218	652	23	4	1233	4	MAN2C1	15	75651976	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	4349647	75651976	26879416	81	37264										
MYLK3	91807	broad.mit.edu	37	chr16	46766260	46766260	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cctgctgcaggcccagggccCcaacctcgtggtcattgtcg	12	16	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:46766260C>A	uc002eei.3	-	4	1438	c.1322G>T	c.(1321-1323)GGG>GTG	p.G441V	MYLK3_uc010vge.1_Missense_Mutation_p.G100V|MYLK3_uc002eej.1_Missense_Mutation_p.G100V	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	441					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GCCCAGGGCCCCAACCTCGTG	0.662													1	0	1.67305e-13	0.000228196	1.68723e-12	38	102										A	46766260	C	A	46766260	3	1	125	1	0	0	0	0	1	0	0	0	10058	623	22	4	1177	4	MYLK3	16	46766260	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		46766260	43588493	82	37265										
CNTNAP4	85445	broad.mit.edu	37	chr16	76481915	76481915	+	Frame_Shift_Del	DEL	A	A	-													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	atctttgtttctaggatcagAagtggttgatcttgatggaa							TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:76481915delA	uc002feu.1	+	7	930	c.545delA	c.(544-546)GAAfs	p.E182fs	CNTNAP4_uc002fev.1_Frame_Shift_Del_p.E94fs|CNTNAP4_uc010chb.1_Frame_Shift_Del_p.E157fs|CNTNAP4_uc002fex.1_Frame_Shift_Del_p.E185fs|CNTNAP4_uc002few.2_Frame_Shift_Del_p.E157fs	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	182	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						CTAGGATCAGAAGTGGTTGAT	0.308																		21	69	---	---								-	76481915	A	-	76481915	7	5	125	1	0	1	0	1	0	0	0	0	3649	246	9	0	576	0	CNTNAP4	16	76481915	Frame_Shift_Del	DEL	A	TCGA-H4-A2HO-01A-11D-A17V-08	29715655	76481915	13872838	83	37266										
BANP	54971	broad.mit.edu	37	chr16	88098939	88098939	+	Splice_Site	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tcaaagccagcagtggccagGtgagtcctttgtacatccca	10	12	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:88098939G>T	uc002fkr.2	+	12	1565	c.1341_splice	c.e12+1	p.Q447_splice	BANP_uc002fkp.2_Splice_Site_p.Q420_splice|BANP_uc002fkq.2_Intron|BANP_uc010vow.1_Intron|BANP_uc002fks.3_Intron	NM_079837	NP_524576	Q8N9N5	BANP_HUMAN	BTG3 associated nuclear protein isoform b						cell cycle|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0				BRCA - Breast invasive adenocarcinoma(80;0.00551)		cagtggccaggtgagtccttt	0													1	0	2.23348e-06	0.000422831	2.09279e-05	15	35										T	88098939	G	T	88098939	5	4	125	1	0	0	0	0	0	0	1	0	1310	1275	44	4	1438	4	BANP	16	88098939	Splice_Site	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	11617024	88098939	2255814	84	37267										
SNAI3	333929	broad.mit.edu	37	chr16	88745035	88745035	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cgagcaggcatagggcttctCccctgtgggaggaaggcggc	17	11	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:88745035C>T	uc002flj.2	-	3	768	c.700G>A	c.(700-702)GAG>AAG	p.E234K	MGC23284_uc002fli.3_Intron	NM_178310	NP_840101	Q3KNW1	SNAI3_HUMAN	snail homolog 3	234					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.048)		TAGGGCTTCTCCCCTGTGGGA	0.612													0	0	0	0.000219431	0	15	23										T	88745035	C	T	88745035	3	4	125	1	0	0	0	0	1	0	0	0	14828	864	30	1	182	1	SNAI3	16	88745035	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	646096	88745035	1609718	85	37268										
GALNS	2588	broad.mit.edu	37	chr16	88893122	88893122	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gcaccaacctgtccatcagcCggccctgcaggagggtgggg	15	14	1	0	rs150734270	byFrequency	TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr16:88893122C>T	uc002fly.3	-	10	1216	c.1127G>A	c.(1126-1128)CGG>CAG	p.R376Q	GALNS_uc010cid.2_Missense_Mutation_p.R382Q|GALNS_uc002flz.3_Missense_Mutation_p.R59Q	NM_000512	NP_000503	P34059	GALNS_HUMAN	galactosamine (N-acetyl)-6-sulfate sulfatase	376			R -> Q (in MPS4A; severe form).			lysosome	metal ion binding|N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity			large_intestine(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GTCCATCAGCCGGCCCTGCAG	0.662													0	0	0	0.000586117	0	21	20										T	88893122	C	T	88893122	3	4	125	1	0	0	0	0	1	0	0	0	6206	652	23	2	461	2	GALNS	16	88893122	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	148087	88893122	1461631	86	37269										
MYBBP1A	10514	broad.mit.edu	37	chr17	4445105	4445105	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gacctttgctaggacctggcCcatcagctgcttccactcgg	10	15	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:4445105C>A	uc002fyb.3	-	23	3231	c.3169G>T	c.(3169-3171)GGC>TGC	p.G1057C	MYBBP1A_uc002fxz.3_Missense_Mutation_p.G1057C|MYBBP1A_uc002fya.3_Missense_Mutation_p.G2C|MYBBP1A_uc010vsa.1_Missense_Mutation_p.G99C	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	1057					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						AGGACCTGGCCCATCAGCTGC	0.627													1	0	1.99505e-19	0.000409698	2.02916e-18	30	96										A	4445105	C	A	4445105	3	1	125	1	0	0	0	0	1	0	0	0	10008	623	22	4	873	4	MYBBP1A	17	4445105	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		4445105	76750105	87	37270										
NCOR1	9611	broad.mit.edu	37	chr17	16029478	16029478	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tttttctgctttatcctcttCtttttcttctactttttctt	1	10	6	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:16029478C>A	uc002gpo.2	-	15	1792	c.1552G>T	c.(1552-1554)GAA>TAA	p.E518*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.E518*|NCOR1_uc002gpp.1_Nonsense_Mutation_p.E409*|NCOR1_uc002gpr.2_Nonsense_Mutation_p.E409*|NCOR1_uc002gps.1_Nonsense_Mutation_p.E527*|NCOR1_uc010coz.1_Nonsense_Mutation_p.E334*|NCOR1_uc010cpb.1_Nonsense_Mutation_p.E528*|NCOR1_uc010cpa.1_Nonsense_Mutation_p.E519*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	518	Potential.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ttatcctcttctttttcttct	0.179													1	0	6.49762e-13	0.00074312	6.49762e-12	19	28										A	16029478	C	A	16029478	4	1	125	1	0	0	0	0	0	1	0	0	10235	922	32	3	5898	3	NCOR1	17	16029478	Nonsense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	11584373	16029478	65165732	88	37271										
SLC13A2	9058	broad.mit.edu	37	chr17	26821083	26821083	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttcatcggcataattatgttCatcataccctccaagttccc	4	13	3	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:26821083C>T	uc002hbh.2	+	8	1213	c.1146C>T	c.(1144-1146)TTC>TTT	p.F382F	SLC13A2_uc010wal.1_3'UTR|SLC13A2_uc010wam.1_Silent_p.F338F|SLC13A2_uc010wan.1_Silent_p.F431F|SLC13A2_uc010wao.1_Silent_p.F339F|SLC13A2_uc002hbi.2_Silent_p.F311F	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	382	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	TAATTATGTTCATCATACCCT	0.607													0	0	0	0.000175454	0	17	91										T	26821083	C	T	26821083	2	4	125	1	0	0	0	0	0	0	0	1	14392	825	29	1		1	SLC13A2	17	26821083	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	10791605	26821083	54374127	89	37272										
SRCIN1	80725	broad.mit.edu	37	chr17	36705305	36705305	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gtggtaccttgatgaaggccGagtccttcttgctggtgacc	13	10	1	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:36705305G>A	uc002hqd.2	-	16	3329	c.3104C>T	c.(3103-3105)TCG>TTG	p.S1035L	SRCIN1_uc002hqf.1_Missense_Mutation_p.S907L|SRCIN1_uc002hqe.2_Missense_Mutation_p.S889L	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	907					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						GATGAAGGCCGAGTCCTTCTT	0.632													0	0	0	0.000319135	0	35	62										A	36705305	G	A	36705305	3	1	125	1	0	0	0	0	1	0	0	0	15135	1059	37	1	463	1	SRCIN1	17	36705305	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	9884222	36705305	44489905	90	37273										
PTRF	284119	broad.mit.edu	37	chr17	40556948	40556949	+	Frame_Shift_Del	DEL	GC	GC	-													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttgtagaccgcggtcttggaGcgcgcgtacaccacgtggtc							TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:40556948_40556949delGC	uc002hzo.2	-	2	1088_1089	c.929_930delGC	c.(928-930)CGCfs	p.R310fs	PTRF_uc010wgi.1_Frame_Shift_Del_p.R292fs	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	310					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CGGTCTTGGAGCGCGCGTACAC	0.649																		26	94	---	---								-	40556949	GC	-	40556948	7	5	125	1	0	1	0	1	0	0	0	0	12815	958	34	0	246	0	PTRF	17	40556948	Frame_Shift_Del	DEL	GC	TCGA-H4-A2HO-01A-11D-A17V-08	3851643	40556948	40638262	91	37274										
C17orf57	124989	broad.mit.edu	37	chr17	45447812	45447812	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ttctattacaggtaaccacaTggtggatattggggatatta	10	5	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr17:45447812T>C	uc002iln.2	+	11	1226	c.815T>C	c.(814-816)ATG>ACG	p.M272T	C17orf57_uc002ilm.2_Missense_Mutation_p.M176T|C17orf57_uc002ill.1_Missense_Mutation_p.M28T|C17orf57_uc010daz.1_Missense_Mutation_p.M224T	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	272							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GGTAACCACATGGTGGATATT	0.318													0	0	0	0.000375601	0	23	54										C	45447812	T	C	45447812	3	2	125	1	0	0	0	0	1	0	0	0	1865	1464	51	5	845	5	C17orf57	17	45447812	Missense_Mutation	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	4890864	45447812	35747398	92	37275										
ANKRD30B	374860	broad.mit.edu	37	chr18	14779986	14779986	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gttcccatcagaatccaaacGagaggaagatgaagaatatt	9	7	1	5	rs76927023	byFrequency	TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr18:14779986G>A	uc010dlo.2	+	11	1628	c.1448G>A	c.(1447-1449)CGA>CAA	p.R483Q	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	483										ovary(1)|skin(1)	2						GAATCCAAACGAGAGGAAGAT	0.284													0	0	0	0.000673444	0	7	29										A	14779986	G	A	14779986	3	1	125	1	0	0	0	0	1	0	0	0	659	1058	37	1	1490	1	ANKRD30B	18	14779986	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		14779986	63297262	93	37276										
CCDC102B	79839	broad.mit.edu	37	chr18	66678339	66678339	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gactcaatcaaaaagaagatGaggtactactttatgagtga	9	5	2	5			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr18:66678339G>A	uc002lkk.2	+	9	1655	c.1432G>A	c.(1432-1434)GAG>AAG	p.E478K	CCDC102B_uc002lki.2_Missense_Mutation_p.E478K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	478	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AAAAGAAGATGAGGTACTACT	0.368													0	0	0	3.59834e-05	0	6	33										A	66678339	G	A	66678339	3	1	125	1	0	0	0	0	1	0	0	0	2737	1291	45	1	1454	1	CCDC102B	18	66678339	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	51898353	66678339	11398909	94	37277										
MUC16	94025	broad.mit.edu	37	chr19	9014673	9014673	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	acggtgggtgcagatggcatCcactccagtggctgctccat	13	12	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:9014673C>G	uc002mkp.2	-	31	38506	c.38302G>C	c.(38302-38304)GAT>CAT	p.D12768H	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12770	SEA 5.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGATGGCATCCACTCCAGTG	0.547													0	0	0	0.000227799	0	20	28										G	9014673	C	G	9014673	3	3	125	1	0	0	0	0	1	0	0	0	9973	855	30	1	5437	1	MUC16	19	9014673	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		9014673	50114310	95	37278										
MUC16	94025	broad.mit.edu	37	chr19	9017487	9017487	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	acggtgggtgcagatggcatCcactccagtggctgctccat	13	12	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:9017487C>G	uc002mkp.2	-	26	38041	c.37837G>C	c.(37837-37839)GAT>CAT	p.D12613H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12615	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGATGGCATCCACTCCAGTG	0.547													0	0	0	0.00010058	0	8	75										G	9017487	C	G	9017487	3	3	125	1	0	0	0	0	1	0	0	0	9973	855	30	1	5922	1	MUC16	19	9017487	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	2814	9017487	50111496	96	37279										
COL5A3	50509	broad.mit.edu	37	chr19	10116237	10116237	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	catcactgaactcctacctcGaaagtcttttccccaaggtc	5	15	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:10116237G>A	uc002mmq.1	-	4	677	c.591C>T	c.(589-591)TTC>TTT	p.F197F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	197	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTCCTACCTCGAAAGTCTTTT	0.532													0	0	0	0.000151284	0	11	96										A	10116237	G	A	10116237	2	1	125	1	0	0	0	0	0	0	0	1	3698	1049	37	1		1	COL5A3	19	10116237	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	1098750	10116237	49012746	97	37280										
ICAM3	3385	broad.mit.edu	37	chr19	10445810	10445811	+	Missense_Mutation	DNP	CG	CG	AT													0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tcacgttgcagacgatctccCgggcaccctcctgatccgcg							TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:10445810_10445811CG>AT	uc002mob.2	-	4	923_924	c.868_869CG>AT	c.(868-870)CGG>ATG	p.R290M	RAVER1_uc002moa.2_5'Flank|ICAM3_uc010dxd.1_Missense_Mutation_p.R213M|ICAM3_uc010xlf.1_3'UTR	NM_002162	NP_002153	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3 precursor	290	Extracellular (Potential).|Ig-like C2-type 3.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			GACGATCTCCCGGGCACCCTCC	0.668													0	0	0	6.4e-05	0	13	274										AT	10445811	CG	AT	10445810	3	1	125	1	0	0	0	0	1	0	0	0	7481	652	23	4	790	4	ICAM3	19	10445810	Missense_Mutation	DNP	CG	TCGA-H4-A2HO-01A-11D-A17V-08	329573	10445810	48683173	98	37281										
CYP4F12	66002	broad.mit.edu	37	chr19	15791063	15791063	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gttcatgtcagctgccattgCacccaaggataatctcttca	7	12	4	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:15791063C>T	uc002nbl.2	+	4	414	c.353C>T	c.(352-354)GCA>GTA	p.A118V	CYP4F12_uc010xoo.1_Missense_Mutation_p.A118V|CYP4F12_uc010xop.1_Missense_Mutation_p.A118V	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GCTGCCATTGCACCCAAGGAT	0.567													0	0	0	0.000781405	0	67	174										T	15791063	C	T	15791063	3	4	125	1	0	0	0	0	1	0	0	0	4187	710	25	2	363	2	CYP4F12	19	15791063	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	5345253	15791063	43337920	99	37282										
MAST3	23031	broad.mit.edu	37	chr19	18245741	18245741	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	atgagtttctggtgggctgcGtgcctttctttggagatacc	13	8	2	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:18245741G>A	uc002nhz.3	+	16	1732	c.1732G>A	c.(1732-1734)GTG>ATG	p.V578M		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	578	Protein kinase.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GGTGGGCTGCGTGCCTTTCTT	0.617													0	0	0	0.000781405	0	45	91										A	18245741	G	A	18245741	3	1	125	1	0	0	0	0	1	0	0	0	9326	1145	40	2	1794	2	MAST3	19	18245741	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	2454678	18245741	40883242	100	37283										
ZNF569	148266	broad.mit.edu	37	chr19	37903795	37903795	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cacaataagggaagttctttGagagaaggctttcccacatt	9	8	1	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:37903795G>A	uc002ogi.2	-	6	2323	c.1765C>T	c.(1765-1767)CAA>TAA	p.Q589*	ZNF569_uc002ogh.2_Nonsense_Mutation_p.Q430*|ZNF569_uc002ogj.2_Nonsense_Mutation_p.Q613*	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	589	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGTTCTTTGAGAGAAGGCT	0.418													0	0	0	0.000339439	0	32	72										A	37903795	G	A	37903795	4	1	125	1	0	0	0	0	0	1	0	0	17997	1299	45	1	299	1	ZNF569	19	37903795	Nonsense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	19658054	37903795	21225188	101	37284										
SIPA1L3	23094	broad.mit.edu	37	chr19	38682830	38682830	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gtctttgggcaaccgaggttGagggcatccctccgagacct	13	12	1	2			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:38682830G>A	uc002ohk.2	+	17	4985	c.4476G>A	c.(4474-4476)TTG>TTA	p.L1492L		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1492					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AACCGAGGTTGAGGGCATCCC	0.552													0	0	0	0.000295444	0	21	44										A	38682830	G	A	38682830	2	1	125	1	0	0	0	0	0	0	0	1	14331	1281	45	1		1	SIPA1L3	19	38682830	Silent	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	779035	38682830	20446153	102	37285										
NUMBL	9253	broad.mit.edu	37	chr19	41188699	41188699	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aggacagacttcacggacttTcggcccatctggagggaggc	14	11	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:41188699T>C	uc002oon.2	-	5	501	c.333A>G	c.(331-333)CGA>CGG	p.R111R	NUMBL_uc010xvq.1_Silent_p.R70R|NUMBL_uc002ooo.2_Silent_p.R111R|NUMBL_uc010xvr.1_Silent_p.R70R	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	111	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			TCACGGACTTTCGGCCCATCT	0.657													0	0	0	0.000308642	0	15	55										C	41188699	T	C	41188699	2	2	125	1	0	0	0	0	0	0	0	1	10752	1770	62	5		5	NUMBL	19	41188699	Silent	SNP	T	TCGA-H4-A2HO-01A-11D-A17V-08	2505869	41188699	17940284	103	37286										
ERCC2	2068	broad.mit.edu	37	chr19	45867337	45867337	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cagcccctccaccagacgccGgtactcgtcccgcaggcgct	10	20	0	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:45867337G>A	uc002pbj.2	-	10	903	c.856C>T	c.(856-858)CGG>TGG	p.R286W	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.R208W|ERCC2_uc002pbk.2_Missense_Mutation_p.R262W|ERCC2_uc002pbl.3_Missense_Mutation_p.R262W|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	286					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		ACCAGACGCCGGTACTCGTCC	0.701			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.000274275	0	9	16										A	45867337	G	A	45867337	3	1	125	1	0	0	0	0	1	0	0	0	5213	1115	39	2	1539	2	ERCC2	19	45867337	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	4678638	45867337	13261646	104	37287										
PLA2G4C	8605	broad.mit.edu	37	chr19	48609779	48609779	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tcagctctaagaggacttacCttcccatggtgcactgcggt	10	12	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr19:48609779C>T	uc002phx.2	-	2	406	c.8G>A	c.(7-9)AGC>AAC	p.S3N	PLA2G4C_uc002phw.2_5'Flank|PLA2G4C_uc010elr.2_Missense_Mutation_p.S3N|PLA2G4C_uc010xzd.1_Silent_p.K23K|PLA2G4C_uc002phy.3_Missense_Mutation_p.S3N	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	3	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		GAGGACTTACCTTCCCATGGT	0.502													0	0	0	0.000319135	0	38	82										T	48609779	C	T	48609779	3	4	125	1	0	0	0	0	1	0	0	0	12003	695	24	2	1685	2	PLA2G4C	19	48609779	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	2742442	48609779	10519204	105	37288										
ZNF343	79175	broad.mit.edu	37	chr20	2464291	2464291	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agcctcgcccacactccctgCaaacataaggcttctcatcc	5	18	1	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:2464291C>A	uc002wge.1	-	6	1804	c.1316G>T	c.(1315-1317)TGC>TTC	p.C439F	ZNF343_uc010gao.1_Missense_Mutation_p.C439F|ZNF343_uc002wgd.1_Missense_Mutation_p.C349F	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	439	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACACTCCCTGCAAACATAAGG	0.522													1	0	6.72482e-11	0.000308642	6.61367e-10	16	41										A	2464291	C	A	2464291	3	1	125	1	0	0	0	0	1	0	0	0	17855	710	25	4	487	4	ZNF343	20	2464291	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08		2464291	60561229	106	37289										
DLGAP4	22839	broad.mit.edu	37	chr20	35064675	35064675	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	cggcggcagccccaagccctCacccaagaccgcggcgcggc	13	20	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:35064675C>A	uc002xff.2	+	4	1598	c.1163C>A	c.(1162-1164)TCA>TAA	p.S388*	DLGAP4_uc010zvp.1_Nonsense_Mutation_p.S388*	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	388					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCAAGCCCTCACCCAAGACC	0.711													1	0	1.3612e-06	0.000308642	1.28558e-05	14	29										A	35064675	C	A	35064675	4	1	125	1	0	0	0	0	0	1	0	0	4562	838	29	3	1169	3	DLGAP4	20	35064675	Nonsense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	32600384	35064675	27960845	107	37290										
MAFB	9935	broad.mit.edu	37	chr20	39316580	39316580	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	agcccgcctccctgaagccgGagttggcgagtttctcgcac	12	15	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:39316580G>A	uc002xji.2	-	1	1297	c.911C>T	c.(910-912)TCC>TTC	p.S304F		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	304					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				CCTGAAGCCGGAGTTGGCGAG	0.527			T	IGH@	MM								0	0	0	0.000958276	0	19	105										A	39316580	G	A	39316580	3	1	125	1	0	0	0	0	1	0	0	0	9158	1174	41	1	64	1	MAFB	20	39316580	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08	4251905	39316580	23708940	108	37291										
EDN3	1908	broad.mit.edu	37	chr20	57875894	57875894	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ccggggctgtggctccttttCgggctcacagtgacctccgc	13	15	1	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr20:57875894C>T	uc002yap.2	+	1	396	c.27C>T	c.(25-27)TTC>TTT	p.F9F	EDN3_uc002yao.1_Silent_p.F9F|EDN3_uc002yaq.2_Silent_p.F9F|EDN3_uc002yar.2_Silent_p.F9F|EDN3_uc002yas.2_Silent_p.F9F	NM_000114	NP_000105	P14138	EDN3_HUMAN	endothelin 3 isoform 1 preproprotein	9					cell surface receptor linked signaling pathway|inositol phosphate-mediated signaling|neutrophil chemotaxis|peptide hormone secretion|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of leukocyte chemotaxis|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space|soluble fraction	endothelin B receptor binding|hormone activity			skin(1)	1	all_lung(29;0.0115)					GGCTCCTTTTCGGGCTCACAG	0.721													0	0	0	0.000308642	0	12	22										T	57875894	C	T	57875894	2	4	125	1	0	0	0	0	0	0	0	1	4918	883	31	1		1	EDN3	20	57875894	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	18559314	57875894	5149626	109	37292										
POTEH	23784	broad.mit.edu	37	chr22	16287731	16287731	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tcctgagtgtcttcatagcaGaatcgtcgtggtctccagaa	10	10	3	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr22:16287731G>T	uc010gqp.2	-	1	207	c.155C>A	c.(154-156)TCT>TAT	p.S52Y	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Translation_Start_Site	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	52										skin(1)	1						CTTCATAGCAGAATCGTCGTG	0.612													1	0	5.96743e-59	0.000781405	6.17499e-58	87	442										T	16287731	G	T	16287731	3	4	125	1	0	0	0	0	1	0	0	0	12267	942	33	3	1522	3	POTEH	22	16287731	Missense_Mutation	SNP	G	TCGA-H4-A2HO-01A-11D-A17V-08		16287731	35016835	110	37293										
TOB2	10766	broad.mit.edu	37	chr22	41833080	41833080	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	aagggatcaatccagacactCagctcctcaggcacattggc	9	13	3	1	rs61756254		TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chr22:41833080C>T	uc003azz.1	-	2	977	c.270G>A	c.(268-270)CTG>CTA	p.L90L		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	90					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1						TCCAGACACTCAGCTCCTCAG	0.597													0	0	0	0.000589545	0	40	88										T	41833080	C	T	41833080	2	4	125	1	0	0	0	0	0	0	0	1	16345	813	29	1		1	TOB2	22	41833080	Silent	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	25545349	41833080	9471486	111	37294										
IQSEC2	23096	broad.mit.edu	37	chrX	53283763	53283763	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	atgtcattagaaaactctccAgatgtggtgacggagcttcc	10	9	2	3			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:53283763A>G	uc004dsd.2	-	4	1551	c.1350T>C	c.(1348-1350)TCT>TCC	p.S450S	IQSEC2_uc004dsc.2_Silent_p.S245S	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	440					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						AAAACTCTCCAGATGTGGTGA	0.572													0	0	0	0.000184323	0	27	30										G	53283763	A	G	53283763	2	3	125	1	0	0	0	0	0	0	0	1	7818	175	7	5		5	IQSEC2	23	53283763	Silent	SNP	A	TCGA-H4-A2HO-01A-11D-A17V-08		53283763	101986797	112	37295										
EFNB1	1947	broad.mit.edu	37	chrX	68060145	68060145	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	tgggggcagcagcggggaccCtgatggcttcttcaactcca	14	12	2	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:68060145C>T	uc004dxd.3	+	5	1469	c.689C>T	c.(688-690)CCT>CTT	p.P230L	EFNB1_uc004dxe.2_Missense_Mutation_p.P230L	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	230	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						AGCGGGGACCCTGATGGCTTC	0.582													0	0	0	8.12818e-05	0	6	31										T	68060145	C	T	68060145	3	4	125	1	0	0	0	0	1	0	0	0	4955	681	24	2	707	2	EFNB1	23	68060145	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	14776382	68060145	87210415	113	37296										
SLC6A14	11254	broad.mit.edu	37	chrX	115584268	115584268	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	ccatattattttttttcatgCttttaactttgggtctcgat	5	7	2	0			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:115584268C>T	uc004eqi.2	+	9	1350	c.1246C>T	c.(1246-1248)CTT>TTT	p.L416F		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	416	Helical; Name=8; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTTTTTCATGCTTTTAACTTT	0.378													0	0	0	0.000720815	0	26	11										T	115584268	C	T	115584268	3	4	125	1	0	0	0	0	1	0	0	0	14677	797	28	2	1280	2	SLC6A14	23	115584268	Missense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	47524123	115584268	39686292	114	37297										
LONRF3	79836	broad.mit.edu	37	chrX	118109240	118109240	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.217391304347826	25	1.71689207182869e-05	2.48917748917749	4.08888888888889	2.10215053763441	0.0373675354940918	0.0991383594741211	15	gaaatgtcatgggtttctatCagaccccgtgtccttgtcgt	10	10	3	1			TCGA-H4-A2HO-01A-11D-A17V-08	TCGA-H4-A2HO-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e327841-eef0-42dd-883e-7d5b5a0d3a93	ca6fa0fa-acad-4b0e-8fa7-33391d18e353	g.chrX:118109240C>G	uc004eqw.2	+	1	528	c.497C>G	c.(496-498)TCA>TGA	p.S166*	LONRF3_uc004eqx.2_Nonsense_Mutation_p.S166*|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_5'Flank	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	166	RING-type 1.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						GGGTTTCTATCAGACCCCGTG	0.672													0	0	0	0.00047179	0	21	6										G	118109240	C	G	118109240	4	3	125	1	0	0	0	0	0	1	0	0	8896	838	29	1	499	1	LONRF3	23	118109240	Nonsense_Mutation	SNP	C	TCGA-H4-A2HO-01A-11D-A17V-08	2524972	118109240	37161320	115	37298										
TAS1R3	83756	broad.mit.edu	37	chr1	1268732	1268732	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctacgactgtgtggactgcGaggcgggcagctaccggcaa	16	11	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:1268732G>A	uc010nyk.1	+	5	1573	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	525	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGTGGACTGCGAGGCGGGCAG	0.692													0	0	0	0.001984	0	7	21										A	1268732	G	A	1268732	3	1	126	1	0	0	0	0	1	0	0	0	15561	1059	37	1	1591	1	TAS1R3	1	1268732	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		1268732	247981889	1	37299										
PRDM16	63976	broad.mit.edu	37	chr1	3102752	3102752	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctgctggccagccacagcgCggaggacgaggccgaggaca	16	14	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:3102752C>A	uc001akf.2	+	2	181	c.101C>A	c.(100-102)GCG>GAG	p.A34E	PRDM16_uc001akc.2_Missense_Mutation_p.A34E|PRDM16_uc001akd.2_Missense_Mutation_p.A34E|PRDM16_uc001ake.2_Missense_Mutation_p.A34E|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	34					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCCACAGCGCGGAGGACGAG	0.642			T	EVI1	MDS|AML								1	0	1.33834e-09	0.007413	1.79893e-09	17	111										A	3102752	C	A	3102752	3	1	126	1	0	0	0	0	1	0	0	0	12457	768	27	4	107	4	PRDM16	1	3102752	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1834020	3102752	246147869	2	37300										
C1orf127	148345	broad.mit.edu	37	chr1	11007721	11007721	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctggagtctccatggaggctCagcgtgagggcctctcagaa	14	11	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:11007721C>T	uc010oao.1	-	8	2029	c.2024G>A	c.(2023-2025)TGA>TAA	p.*675*	C1orf127_uc001arr.1_Silent_p.*657*|C1orf127_uc001ars.1_Silent_p.*649*	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345	675										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CATGGAGGCTCAGCGTGAGGG	0.637													0	0	0	0.009096	0	4	20										T	11007721	C	T	11007721	2	4	126	1	0	0	0	0	0	0	0	1	1994	837	29	1		1	C1orf127	1	11007721	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7904969	11007721	238242900	3	37301										
MIIP	60672	broad.mit.edu	37	chr1	12090089	12090089	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgcccccctgcgcagggtgAgcatcccgctgtcgatcctg	12	17	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:12090089A>T	uc001ato.1	+	8	1030	c.850A>T	c.(850-852)AGC>TGC	p.S284C		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	284										ovary(1)	1						GCGCAGGGTGAGCATCCCGCT	0.667													0	0	0	0.007413	0	19	83										T	12090089	A	T	12090089	3	4	126	1	0	0	0	0	1	0	0	0	9585	304	11	5	876	5	MIIP	1	12090089	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1082368	12090089	237160532	4	37302										
VPS13D	55187	broad.mit.edu	37	chr1	12429573	12429573	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgaacccaggctccggactGaagtgaagcccatgacttca	10	13	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:12429573G>T	uc001atv.2	+	54	10765	c.10624G>T	c.(10624-10626)GAA>TAA	p.E3542*	VPS13D_uc001atw.2_Nonsense_Mutation_p.E3517*|VPS13D_uc001atx.2_Nonsense_Mutation_p.E2729*|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3541					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCTCCGGACTGAAGTGAAGCC	0.517													1	0	1.88708e-17	0.008361	2.62165e-17	28	181										T	12429573	G	T	12429573	4	4	126	1	0	0	0	0	0	1	0	0	17189	1291	45	3	10834	3	VPS13D	1	12429573	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	339484	12429573	236821048	5	37303										
AADACL3	126767	broad.mit.edu	37	chr1	12785550	12785550	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagaggtcatcatgaaaggtGcccatttgcctgctgaagtc	11	9	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:12785550G>A	uc009vnn.1	+	4	873	c.640G>A	c.(640-642)GCC>ACC	p.A214T	AADACL3_uc001aug.1_Missense_Mutation_p.A144T	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3 isoform 1	214							hydrolase activity				0	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CATGAAAGGTGCCCATTTGCC	0.483													0	0	0	0.01441	0	76	61										A	12785550	G	A	12785550	3	1	126	1	0	0	0	0	1	0	0	0	12	1319	46	2	658	2	AADACL3	1	12785550	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	355977	12785550	236465071	6	37304										
LOC440563	440563	broad.mit.edu	37	chr1	13183214	13183214	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tactgctctgctcctcttctGacttagcatttttcacctct	4	14	5	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:13183214G>A	uc010obg.1	-	1	754	c.659C>T	c.(658-660)TCA>TTA	p.S220L		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	220						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CTCCTCTTCTGACTTAGCATT	0.458													0	0	0	0.00874	0	36	120										A	13183214	G	A	13183214	3	1	126	1	0	0	0	0	1	0	0	0	8879	1294	45	1	226	1	LOC440563	1	13183214	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	397664	13183214	236067407	7	37305										
CELA2B	51032	broad.mit.edu	37	chr1	15813791	15813791	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttcctcagggagactccggTgggccgctgaactgtcaggc	14	13	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:15813791T>A	uc001awl.2	+	7	676	c.651T>A	c.(649-651)GGT>GGA	p.G217G		NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	217	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						GAGACTCCGGTGGGCCGCTGA	0.562													0	0	0	0.015359	0	30	137										A	15813791	T	A	15813791	2	1	126	1	0	0	0	0	0	0	0	1	3212	1683	59	5		5	CELA2B	1	15813791	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	2630577	15813791	233436830	8	37306										
PLEKHM2	23207	broad.mit.edu	37	chr1	16060340	16060340	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagcctccaacaagaagaaaTtcgaggatgccttgagcctc	9	11	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:16060340T>G	uc010obo.1	+	20	3198	c.2971T>G	c.(2971-2973)TTC>GTC	p.F991V	SLC25A34_uc001axb.1_5'Flank	NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	991					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		CAAGAAGAAATTCGAGGATGC	0.642													0	0	0	0.017118	0	34	130										G	16060340	T	G	16060340	3	3	126	1	0	0	0	0	1	0	0	0	12081	1493	52	5	3049	5	PLEKHM2	1	16060340	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	246549	16060340	233190281	9	37307										
EPHA2	1969	broad.mit.edu	37	chr1	16459810	16459810	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttgatggccaccggcacctCcttcttccccgaggatgtct	9	16	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:16459810C>A	uc001aya.1	-	11	2055	c.1918G>T	c.(1918-1920)GAG>TAG	p.E640*		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	640	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	ACCGGCACCTCCTTCTTCCCC	0.627													1	0	9.86323e-18	0.021523	1.37256e-17	22	113										A	16459810	C	A	16459810	4	1	126	1	0	0	0	0	0	1	0	0	5167	864	30	3	1040	3	EPHA2	1	16459810	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	399470	16459810	232790811	10	37308										
ATP13A2	23400	broad.mit.edu	37	chr1	17314949	17314949	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacagtcattggcgccgtctCcgcacatgcccacgcagtac	9	17	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:17314949C>G	uc001baa.2	-	24	2820	c.2630G>C	c.(2629-2631)GGA>GCA	p.G877A	ATP13A2_uc001azz.1_Missense_Mutation_p.G24A|ATP13A2_uc001bab.2_Missense_Mutation_p.G872A|ATP13A2_uc001bac.2_Missense_Mutation_p.G833A	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	877	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		GGCGCCGTCTCCGCACATGCC	0.592													0	0	0	0.015359	0	32	141										G	17314949	C	G	17314949	3	3	126	1	0	0	0	0	1	0	0	0	1124	855	30	1	1172	1	ATP13A2	1	17314949	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	855139	17314949	231935672	11	37309										
UBR4	23352	broad.mit.edu	37	chr1	19441311	19441311	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agatctggcctcaccttcttCcggtcttcttcattctcaat	5	14	7	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:19441311C>T	uc001bbi.2	-	75	11200	c.11196G>A	c.(11194-11196)CGG>CGA	p.R3732R	UBR4_uc001bbj.1_Silent_p.R147R	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3732					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCACCTTCTTCCGGTCTTCTT	0.522													0	0	0	0.007835	0	33	183										T	19441311	C	T	19441311	2	4	126	1	0	0	0	0	0	0	0	1	16901	842	30	1		1	UBR4	1	19441311	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2126362	19441311	229809310	12	37310										
TMCO4	255104	broad.mit.edu	37	chr1	20107215	20107215	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcagctaccagaggctgctGaggcagcctctggcatggcc	13	14	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:20107215G>C	uc001bcn.2	-	4	279	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	TMCO4_uc001bcm.2_Missense_Mutation_p.Q13E|TMCO4_uc001bco.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcp.1_Missense_Mutation_p.Q13E|TMCO4_uc009vpn.1_Missense_Mutation_p.Q13E|TMCO4_uc001bcq.1_Missense_Mutation_p.Q13E	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	13						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AGAGGCTGCTGAGGCAGCCTC	0.498													0	0	0	0.001168	0	6	46										C	20107215	G	C	20107215	3	2	126	1	0	0	0	0	1	0	0	0	15995	1299	45	1	1919	1	TMCO4	1	20107215	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	665904	20107215	229143406	13	37311										
KIF17	57576	broad.mit.edu	37	chr1	21042025	21042025	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgctcgaaggccctggggatGatgcctctctgggagggcgg	18	10	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:21042025G>C	uc001bdr.3	-	2	457	c.339C>G	c.(337-339)ATC>ATG	p.I113M	KIF17_uc001bds.3_Missense_Mutation_p.I113M	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	113	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CCCTGGGGATGATGCCTCTCT	0.652													0	0	0	0.004656	0	25	107										C	21042025	G	C	21042025	3	2	126	1	0	0	0	0	1	0	0	0	8279	1280	45	1	2806	1	KIF17	1	21042025	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	934810	21042025	228208596	14	37312										
RPL11	6135	broad.mit.edu	37	chr1	24021182	24021182	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagttaagaaaaaacaacttCtcagatactggaaactttgg	8	6	1	2	rs1059937		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:24021182C>T	uc001bhk.2	+	4	317	c.297C>T	c.(295-297)TTC>TTT	p.F99F	RPL11_uc001bhl.2_Silent_p.F98F|RPL11_uc001bhm.2_Silent_p.F88F|RPL11_uc001bhn.1_Silent_p.F88F	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	99					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		AAAACAACTTCTCAGATACTG	0.438													0	0	0	0.01441	0	84	60										T	24021182	C	T	24021182	2	4	126	1	0	0	0	0	0	0	0	1	13557	912	32	1		1	RPL11	1	24021182	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2979157	24021182	225229439	15	37313										
RPL11	6135	broad.mit.edu	37	chr1	24021260	24021260	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tatgacccaagcattggtatCtacggcctggacttctatgt	9	10	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:24021260C>G	uc001bhk.2	+	4	395	c.375C>G	c.(373-375)ATC>ATG	p.I125M	RPL11_uc001bhl.2_Missense_Mutation_p.I124M|RPL11_uc001bhm.2_Missense_Mutation_p.I114M|RPL11_uc001bhn.1_Missense_Mutation_p.I114M	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	125					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		GCATTGGTATCTACGGCCTGG	0.403													0	0	0	0.01441	0	78	69										G	24021260	C	G	24021260	3	3	126	1	0	0	0	0	1	0	0	0	13557	903	32	1	389	1	RPL11	1	24021260	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	78	24021260	225229361	16	37314										
CSMD2	114784	broad.mit.edu	37	chr1	34208917	34208917	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaagcccctcttccctgtggAgtggtcagtctggaactcga	12	12	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:34208917A>T	uc001bxn.1	-	14	2046	c.2017T>A	c.(2017-2019)TCC>ACC	p.S673T	CSMD2_uc001bxm.1_Missense_Mutation_p.S713T	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	673	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTCCCTGTGGAGTGGTCAGTC	0.597													0	0	0	0.020292	0	14	49										T	34208917	A	T	34208917	3	4	126	1	0	0	0	0	1	0	0	0	3945	304	11	5	8670	5	CSMD2	1	34208917	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	10187657	34208917	215041704	17	37315										
CSMD2	114784	broad.mit.edu	37	chr1	34291361	34291361	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacacctcgagacttcaactCaatttgcttcttgactagag	6	12	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:34291361C>G	uc001bxn.1	-	7	957	c.928G>C	c.(928-930)GAG>CAG	p.E310Q	CSMD2_uc001bxm.1_Missense_Mutation_p.E350Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	310	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GACTTCAACTCAATTTGCTTC	0.537													0	0	0	0.006214	0	9	43										G	34291361	C	G	34291361	3	3	126	1	0	0	0	0	1	0	0	0	3945	835	29	1	9787	1	CSMD2	1	34291361	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	82444	34291361	214959260	18	37316										
ZMYM1	79830	broad.mit.edu	37	chr1	35576046	35576046	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agctaagatggaatcttcttCaggtaatgtttgtttagcaa	9	5	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:35576046C>T	uc001bym.2	+	8	1107	c.959C>T	c.(958-960)TCA>TTA	p.S320L	ZMYM1_uc001byn.2_Missense_Mutation_p.S320L|ZMYM1_uc010ohu.1_Missense_Mutation_p.S320L|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.S245L	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	320	MYM-type 4.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GAATCTTCTTCAGGTAATGTT	0.289													0	0	0	0.003163	0	16	102										T	35576046	C	T	35576046	3	4	126	1	0	0	0	0	1	0	0	0	17696	838	29	1	981	1	ZMYM1	1	35576046	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1284685	35576046	213674575	19	37317										
ZMYM1	79830	broad.mit.edu	37	chr1	35579264	35579264	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgaattcacaagttgacttCtataacagtacacaaattca	4	8	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:35579264C>T	uc001bym.2	+	11	1981	c.1833C>T	c.(1831-1833)TTC>TTT	p.F611F	ZMYM1_uc001byn.2_Silent_p.F611F|ZMYM1_uc010ohu.1_Silent_p.F592F|ZMYM1_uc001byo.2_Silent_p.F251F|ZMYM1_uc009vut.2_Silent_p.F536F	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	611						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAGTTGACTTCTATAACAGTA	0.299													0	0	0	0.004007	0	15	54										T	35579264	C	T	35579264	2	4	126	1	0	0	0	0	0	0	0	1	17696	912	32	1		1	ZMYM1	1	35579264	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3218	35579264	213671357	20	37318										
ZMYM1	79830	broad.mit.edu	37	chr1	35580694	35580694	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagtactgagaactcattttCtaccctgcctcgtcttaaga	6	11	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:35580694C>A	uc001bym.2	+	11	3411	c.3263C>A	c.(3262-3264)TCT>TAT	p.S1088Y	ZMYM1_uc001byn.2_Missense_Mutation_p.S1088Y|ZMYM1_uc010ohu.1_Missense_Mutation_p.S1069Y|ZMYM1_uc001byo.2_Missense_Mutation_p.S728Y|ZMYM1_uc009vut.2_Missense_Mutation_p.S1013Y	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	1088						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AACTCATTTTCTACCCTGCCT	0.398													1	0	3.08376e-08	0.01892	4.11168e-08	25	107										A	35580694	C	A	35580694	3	1	126	1	0	0	0	0	1	0	0	0	17696	913	32	3	3297	3	ZMYM1	1	35580694	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1430	35580694	213669927	21	37319										
EIF2C4	192670	broad.mit.edu	37	chr1	36298149	36298149	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttgttttgcacctcagaaaCaatgtagggaagatttacta	8	7	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:36298149C>T	uc001bzj.1	+	11	1547	c.1357C>T	c.(1357-1359)CAA>TAA	p.Q453*		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	453					mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ACCTCAGAAACAATGTAGGGA	0.398													0	0	0	0.005443	0	26	75										T	36298149	C	T	36298149	4	4	126	1	0	0	0	0	0	1	0	0	5008	479	17	2	1399	2	EIF2C4	1	36298149	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	717455	36298149	212952472	22	37320										
HIVEP3	59269	broad.mit.edu	37	chr1	41978764	41978764	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgctcgaggggccagttctCttcccagggggcagagggtg	18	10	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:41978764C>G	uc001cgz.3	-	8	7341	c.6128G>C	c.(6127-6129)AGA>ACA	p.R2043T	HIVEP3_uc001cha.3_Missense_Mutation_p.R2043T|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2043					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGCCAGTTCTCTTCCCAGGGG	0.637													0	0	0	0.01892	0	22	100										G	41978764	C	G	41978764	3	3	126	1	0	0	0	0	1	0	0	0	7188	913	32	1	1100	1	HIVEP3	1	41978764	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	5680615	41978764	207271857	23	37321										
CCDC23	374969	broad.mit.edu	37	chr1	43282117	43282117	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcacctctgctctttgtctCtgcttcagctcctgctgggc	8	16	5	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:43282117C>G	uc001cib.2	-	2	334	c.99G>C	c.(97-99)CAG>CAC	p.Q33H	ERMAP_uc010ojw.1_5'Flank|ERMAP_uc001cic.1_5'Flank|ERMAP_uc001cid.1_5'Flank	NM_199342	NP_955374	Q8N300	CCD23_HUMAN	coiled-coil domain containing 23	33	Potential.										0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTCTTTGTCTCTGCTTCAGCT	0.473													0	0	0	0.01441	0	45	247										G	43282117	C	G	43282117	3	3	126	1	0	0	0	0	1	0	0	0	2798	912	32	1	109	1	CCDC23	1	43282117	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1303353	43282117	205968504	24	37322										
C1orf83	127428	broad.mit.edu	37	chr1	54520107	54520107	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccctaacaatggataaattCgtcattcgaacgcctagaat	6	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:54520107C>A	uc001cwt.1	+	2	212	c.12C>A	c.(10-12)TTC>TTA	p.F4L	C1orf83_uc001cwu.1_RNA|TMEM59_uc001cwp.2_5'Flank|TMEM59_uc001cwq.2_5'Flank|TMEM59_uc001cwr.2_5'Flank|TMEM59_uc001cws.1_5'Flank	NM_153035	NP_694580	Q96MN5	TEAN2_HUMAN	hypothetical protein LOC127428	4					transcription, DNA-dependent	nucleus	DNA binding				0						TGGATAAATTCGTCATTCGAA	0.478													1	0	0.000308642	0.003163	0.000392558	14	70										A	54520107	C	A	54520107	3	1	126	1	0	0	0	0	1	0	0	0	2060	883	31	3	14	3	C1orf83	1	54520107	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	11237990	54520107	194730514	25	37323										
RAVER2	55225	broad.mit.edu	37	chr1	65273062	65273062	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctcagggtcgcagccttatCttcagagctttccaaacctt	7	13	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:65273062C>T	uc001dbs.1	+	9	1624	c.1546C>T	c.(1546-1548)CTT>TTT	p.L516F	RAVER2_uc001dbt.1_Missense_Mutation_p.L408F|RAVER2_uc010opb.1_Intron	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	529						cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						GCAGCCTTATCTTCAGAGCTT	0.532													0	0	0	0.008291	0	11	99										T	65273062	C	T	65273062	3	4	126	1	0	0	0	0	1	0	0	0	13095	913	32	1	1580	1	RAVER2	1	65273062	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	10752955	65273062	183977559	26	37324										
IL23R	149233	broad.mit.edu	37	chr1	67724193	67724193	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttatgaataataattccagTgagcaggtcctatatgttga	8	6	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:67724193T>G	uc001ddo.2	+	11	1357	c.1272T>G	c.(1270-1272)AGT>AGG	p.S424R	IL23R_uc009waz.2_Missense_Mutation_p.S221R|IL23R_uc001ddp.2_Intron|IL23R_uc010opi.1_RNA|IL23R_uc010opj.1_Missense_Mutation_p.S22R|IL23R_uc010opk.1_3'UTR|IL23R_uc010opl.1_Missense_Mutation_p.S6R|IL23R_uc010opm.1_RNA|IL23R_uc001ddq.2_Missense_Mutation_p.S170R|IL23R_uc010opn.1_Missense_Mutation_p.S269R|IL23R_uc001ddr.2_RNA|IL23R_uc010opo.1_Intron|IL23R_uc010opp.1_Intron|IL23R_uc010opq.1_Intron|IL23R_uc010opr.1_Intron|IL23R_uc010ops.1_Missense_Mutation_p.S221R|IL23R_uc010opt.1_Missense_Mutation_p.S65R|IL23R_uc010opu.1_Missense_Mutation_p.S120R|IL23R_uc010opv.1_Missense_Mutation_p.S182R|IL23R_uc010opw.1_Missense_Mutation_p.S59R|IL23R_uc010opx.1_Missense_Mutation_p.S65R|IL23R_uc010opy.1_Missense_Mutation_p.S191R|IL23R_uc010opz.1_Missense_Mutation_p.S65R|IL23R_uc010oqa.1_Missense_Mutation_p.S65R|IL23R_uc010oqb.1_Missense_Mutation_p.S253R|IL23R_uc010oqc.1_Missense_Mutation_p.S140R|IL23R_uc010oqd.1_Missense_Mutation_p.S59R|IL23R_uc010oqe.1_Missense_Mutation_p.S22R|IL23R_uc010oqf.1_Missense_Mutation_p.S22R|IL23R_uc010oqg.1_Missense_Mutation_p.S22R|IL23R_uc010oqh.1_Missense_Mutation_p.S65R|IL23R_uc001dds.2_Missense_Mutation_p.S169R|IL23R_uc001ddt.2_Missense_Mutation_p.S22R	NM_144701	NP_653302	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor precursor	424	Cytoplasmic (Potential).				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity				0						ATAATTCCAGTGAGCAGGTCC	0.343													0	0	0	0.021523	0	22	180										G	67724193	T	G	67724193	3	3	126	1	0	0	0	0	1	0	0	0	7676	1693	59	5	1310	5	IL23R	1	67724193	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	2451131	67724193	181526428	27	37325										
LRRC7	57554	broad.mit.edu	37	chr1	70504754	70504754	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatcagtggaagtgaaagccGaaaagaggataccaccccct	11	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:70504754G>A	uc001dep.2	+	19	3163	c.3133G>A	c.(3133-3135)GAA>AAA	p.E1045K	LRRC7_uc009wbg.2_Missense_Mutation_p.E329K|LRRC7_uc001deq.2_Missense_Mutation_p.E286K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1045						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						AGTGAAAGCCGAAAAGAGGAT	0.438													0	0	0	0.010729	0	11	33										A	70504754	G	A	70504754	3	1	126	1	0	0	0	0	1	0	0	0	9020	1059	37	1	3207	1	LRRC7	1	70504754	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2780561	70504754	178745867	28	37326										
LRRIQ3	127255	broad.mit.edu	37	chr1	74507428	74507428	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tccgctccaatcgtatgtctTttttaatgattggctttgga	8	8	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:74507428T>A	uc001dfy.3	-	7	1379	c.1187A>T	c.(1186-1188)AAA>ATA	p.K396I	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	396										ovary(2)	2						TCGTATGTCTTTTTTAATGAT	0.343													0	0	0	0.013537	0	12	71										A	74507428	T	A	74507428	3	1	126	1	0	0	0	0	1	0	0	0	9030	1841	64	5	695	5	LRRIQ3	1	74507428	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	4002674	74507428	174743193	29	37327										
FPGT	8790	broad.mit.edu	37	chr1	74670357	74670357	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acatggagtatttgtcttagAtccttttgatgatttaaaac	7	5	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:74670357A>G	uc001dgb.1	+	4	663	c.626A>G	c.(625-627)GAT>GGT	p.D209G	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	209					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TTTGTCTTAGATCCTTTTGAT	0.378													0	0	0	0.020292	0	13	111										G	74670357	A	G	74670357	3	3	126	1	0	0	0	0	1	0	0	0	6037	333	12	5	640	5	FPGT	1	74670357	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	162929	74670357	174580264	30	37328										
LPHN2	23266	broad.mit.edu	37	chr1	82421724	82421724	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttagaaccaacaagggtctCaatgcccacagaaaatattg	7	9	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:82421724C>G	uc001dit.3	+	10	2127	c.1946C>G	c.(1945-1947)TCA>TGA	p.S649*	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Nonsense_Mutation_p.S649*|LPHN2_uc001div.2_Nonsense_Mutation_p.S649*|LPHN2_uc009wcd.2_Nonsense_Mutation_p.S649*|LPHN2_uc001diw.2_Nonsense_Mutation_p.S233*	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	662	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding	p.S649S(1)		ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACAAGGGTCTCAATGCCCACA	0.353													0	0	0	0.007413	0	15	19										G	82421724	C	G	82421724	4	3	126	1	0	0	0	0	0	1	0	0	8916	838	29	1	1976	1	LPHN2	1	82421724	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7751367	82421724	166828897	31	37329										
TTLL7	79739	broad.mit.edu	37	chr1	84335732	84335732	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagttgtaggttggtgttctCaagaagaattgggtgctccc	13	6	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:84335732C>G	uc001djc.2	-	21	2973	c.2577G>C	c.(2575-2577)TTG>TTC	p.L859F	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_Intron	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	859					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TTGGTGTTCTCAAGAAGAATT	0.368													0	0	0	0.020292	0	15	12										G	84335732	C	G	84335732	3	3	126	1	0	0	0	0	1	0	0	0	16729	825	29	1	90	1	TTLL7	1	84335732	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1914008	84335732	164914889	32	37330										
LPAR3	23566	broad.mit.edu	37	chr1	85331077	85331077	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcttacctacctaagacagTcatcaccgtcttcattagct	4	14	5	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:85331077T>C	uc001dkl.2	-	1	766	c.727A>G	c.(727-729)ACT>GCT	p.T243A	LPAR3_uc009wcj.1_Missense_Mutation_p.T243A	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	243	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						CCTAAGACAGTCATCACCGTC	0.368													0	0	0	0.014758	0	4	18										C	85331077	T	C	85331077	3	2	126	1	0	0	0	0	1	0	0	0	8906	1667	58	5	342	5	LPAR3	1	85331077	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	995345	85331077	163919544	33	37331										
HFM1	164045	broad.mit.edu	37	chr1	91784914	91784914	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtgtcaaagcaaaatcttgTatgggaatgcatcctagttg	10	6	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:91784914T>C	uc001doa.3	-	24	2716	c.2616A>G	c.(2614-2616)ATA>ATG	p.I872M	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.I551M|HFM1_uc001dob.3_Missense_Mutation_p.I104M|HFM1_uc010osv.1_Missense_Mutation_p.I556M	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	872	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CAAAATCTTGTATGGGAATGC	0.353													0	0	0	0.010504	0	19	13										C	91784914	T	C	91784914	3	2	126	1	0	0	0	0	1	0	0	0	7083	1628	57	5	1755	5	HFM1	1	91784914	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	6453837	91784914	157465707	34	37332										
TGFBR3	7049	broad.mit.edu	37	chr1	92178024	92178024	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggtgtaatgagacatcctatCagggttcgaatatggagaga	13	5	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:92178024C>G	uc001doh.2	-	13	2408	c.1942G>C	c.(1942-1944)GAT>CAT	p.D648H	TGFBR3_uc009wde.2_Intron|TGFBR3_uc010osy.1_Missense_Mutation_p.D606H|TGFBR3_uc001doi.2_Missense_Mutation_p.D647H|TGFBR3_uc001doj.2_Missense_Mutation_p.D647H	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	648	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GACATCCTATCAGGGTTCGAA	0.393													0	0	0	0.013537	0	12	59										G	92178024	C	G	92178024	3	3	126	1	0	0	0	0	1	0	0	0	15820	826	29	1	633	1	TGFBR3	1	92178024	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	393110	92178024	157072597	35	37333										
NTNG1	22854	broad.mit.edu	37	chr1	107867236	107867236	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacatggatcctaaatccgtGaaggatttatcacagcatac	7	10	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:107867236G>A	uc001dvh.3	+	3	1297	c.579G>A	c.(577-579)GTG>GTA	p.V193V	NTNG1_uc001dvf.3_Silent_p.V193V|NTNG1_uc010out.1_Silent_p.V193V|NTNG1_uc001dvc.3_Silent_p.V193V|NTNG1_uc001dvd.1_Silent_p.V193V	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	193	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CTAAATCCGTGAAGGATTTAT	0.398													0	0	0	0.001168	0	6	15										A	107867236	G	A	107867236	2	1	126	1	0	0	0	0	0	0	0	1	10704	1277	45	1		1	NTNG1	1	107867236	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	15689212	107867236	141383385	36	37334										
RBM15	64783	broad.mit.edu	37	chr1	110882179	110882179	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatgaagggaaaagagcgctCgccagtgaaggccaaacgct	13	9	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:110882179C>A	uc001dzl.1	+	1	235	c.152C>A	c.(151-153)TCG>TAG	p.S51*	RBM15_uc001dzm.1_Nonsense_Mutation_p.S51*|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	51					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AAAGAGCGCTCGCCAGTGAAG	0.647			T	MKL1	acute megakaryocytic leukemia								1	0	0.00185496	0.016723	0.00234132	13	54										A	110882179	C	A	110882179	4	1	126	1	0	0	0	0	0	1	0	0	13116	893	31	3	154	3	RBM15	1	110882179	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3014943	110882179	138368442	37	37335										
SLC16A1	6566	broad.mit.edu	37	chr1	113460090	113460090	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctacaagtcccatagatggtCgggctaccatgtcaacaaaa	8	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:113460090C>A	uc001ecx.2	-	4	1770	c.938G>T	c.(937-939)CGA>CTA	p.R313L	SLC16A1_uc001ecy.2_Missense_Mutation_p.R313L|SLC16A1_uc001ecz.2_Missense_Mutation_p.R313L	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	313	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	CATAGATGGTCGGGCTACCAT	0.433													1	0	3.59834e-05	0.001168	4.64808e-05	6	29										A	113460090	C	A	113460090	3	1	126	1	0	0	0	0	1	0	0	0	14402	884	31	3	572	3	SLC16A1	1	113460090	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2577911	113460090	135790531	38	37336										
CD2	914	broad.mit.edu	37	chr1	117297379	117297379	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tataaaatgggaaaaaacttCagacaagaaaaagattgcac	7	5	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:117297379C>G	uc001egu.3	+	2	217	c.188C>G	c.(187-189)TCA>TGA	p.S63*	CD2_uc010owz.1_Nonsense_Mutation_p.S63*|CD2_uc010oxa.1_Nonsense_Mutation_p.S63*	NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	63	Extracellular (Potential).|LFA-3 (CD58) binding region 1.|Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GAAAAAACTTCAGACAAGAAA	0.348													0	0	0	0.001984	0	7	66										G	117297379	C	G	117297379	4	3	126	1	0	0	0	0	0	1	0	0	2979	838	29	1	194	1	CD2	1	117297379	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3837289	117297379	131953242	39	37337										
ACP6	51205	broad.mit.edu	37	chr1	147126339	147126339	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccacgttgtccaggaggatGaagaagtccactttatcact	10	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:147126339G>T	uc001epr.2	-	6	1214	c.750C>A	c.(748-750)TTC>TTA	p.F250L	ACP6_uc009wjj.1_Missense_Mutation_p.F207L	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	250					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					CCAGGAGGATGAAGAAGTCCA	0.537													1	0	8.12818e-05	0.001984	0.000104505	7	128										T	147126339	G	T	147126339	3	4	126	1	0	0	0	0	1	0	0	0	165	1281	45	3	556	3	ACP6	1	147126339	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	29828960	147126339	102124282	40	37338										
RPRD2	23248	broad.mit.edu	37	chr1	150444194	150444194	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgtaagagggaatgaacctGggtctgaccggtcaccatca	13	10	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:150444194G>A	uc009wlr.2	+	11	2971	c.2770G>A	c.(2770-2772)GGG>AGG	p.G924R	RPRD2_uc010pcc.1_Missense_Mutation_p.G898R|RPRD2_uc001eup.3_Missense_Mutation_p.G898R	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	924	Ser-rich.						protein binding			ovary(1)	1						GAATGAACCTGGGTCTGACCG	0.502													0	0	0	0.01441	0	81	288										A	150444194	G	A	150444194	3	1	126	1	0	0	0	0	1	0	0	0	13617	1348	47	2	2812	2	RPRD2	1	150444194	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3317855	150444194	98806427	41	37339										
MCL1	4170	broad.mit.edu	37	chr1	150551725	150551725	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggcgcgaagaaaagcagcctCgcgggggtcgcggtgacgtc	18	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:150551725C>G	uc001euz.2	-	1	412	c.282G>C	c.(280-282)GCG>GCC	p.A94A	MCL1_uc010pch.1_5'UTR|MCL1_uc001eva.2_Silent_p.A94A	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	94					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AAAGCAGCCTCGCGGGGGTCG	0.751													0	0	0	0.00308	0	5	14										G	150551725	C	G	150551725	2	3	126	1	0	0	0	0	0	0	0	1	9384	871	31	1		1	MCL1	1	150551725	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	107531	150551725	98698896	42	37340										
PGLYRP3	114771	broad.mit.edu	37	chr1	153270479	153270479	+	Frame_Shift_Del	DEL	G	G	-													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatgatgttatacaaagcctGcccaggggacaggatgttga							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:153270479delG	uc001fbn.1	-	7	1032	c.979delC	c.(979-981)CAGfs	p.Q327fs		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	327					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TACAAAGCCTGCCCAGGGGAC	0.587																		98	179	---	---								-	153270479	G	-	153270479	7	5	126	1	0	1	0	1	0	0	0	0	11795	1328	46	0	50	0	PGLYRP3	1	153270479	Frame_Shift_Del	DEL	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2718754	153270479	95980142	43	37341										
FCER1A	2205	broad.mit.edu	37	chr1	159273962	159273962	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtgaacctgtgtacctggaAgtcttcagtggtaagttcca	11	8	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:159273962A>C	uc001ftq.2	+	4	420	c.321A>C	c.(319-321)GAA>GAC	p.E107D		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	107	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	TGTACCTGGAAGTCTTCAGTG	0.403													0	0	0	0.001984	0	6	87										C	159273962	A	C	159273962	3	2	126	1	0	0	0	0	1	0	0	0	5774	69	3	5	331	5	FCER1A	1	159273962	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	6003483	159273962	89976659	44	37342										
MPZ	4359	broad.mit.edu	37	chr1	161276626	161276626	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgacaatggagccatccttcCagcgagggtcccctacccac	9	16	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:161276626C>T	uc001gaf.3	-	3	387	c.350G>A	c.(349-351)TGG>TAG	p.W117*	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	107	Ig-like V-type.|Extracellular (Potential).				synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			GCCATCCTTCCAGCGAGGGTC	0.517													0	0	0	0.01441	0	54	478										T	161276626	C	T	161276626	4	4	126	1	0	0	0	0	0	1	0	0	9748	595	21	2	442	2	MPZ	1	161276626	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2002664	161276626	87973995	45	37343										
BAT2L2	23215	broad.mit.edu	37	chr1	171484935	171484936	+	Frame_Shift_Ins	INS	-	-	A													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcaggcagctggggatcaggINSaaaaaaaagaaaaggaaaca							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:171484935_171484936insA	uc010pmg.1	+	5	723_724	c.457_458insA	c.(457-459)GAAfs	p.E153fs	BAT2L2_uc001ghq.1_Frame_Shift_Ins_p.E150fs|BAT2L2_uc001ghr.1_Frame_Shift_Ins_p.E155fs	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	153							protein C-terminus binding				0						TGGGGATCAGGAAAAAAAAGAA	0.356																		7	249	---	---								A	171484936	-	A	171484935	7	5	126	1	0	1	1	0	0	0	0	0	1321	1175	41	0	471	0	BAT2L2	1	171484935	Frame_Shift_Ins	INS	-	TCGA-H4-A2HQ-01A-11D-A17V-08	10208309	171484935	77765686	46	37344										
C1orf9	51430	broad.mit.edu	37	chr1	172526519	172526519	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaggcccttgatgctagtgcTccaattgaacaaccttcctt	8	12	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:172526519T>A	uc001giq.3	+	5	859	c.543T>A	c.(541-543)GCT>GCA	p.A181A	C1orf9_uc010pmm.1_Silent_p.A181A|C1orf9_uc009wwd.2_Silent_p.A144A|C1orf9_uc010pmn.1_Silent_p.A144A|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	181					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		ATGCTAGTGCTCCAATTGAAC	0.433													0	0	0	0.01441	0	169	75										A	172526519	T	A	172526519	2	1	126	1	0	0	0	0	0	0	0	1	2067	1538	54	5		5	C1orf9	1	172526519	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	1041584	172526519	76724102	47	37345										
DARS2	55157	broad.mit.edu	37	chr1	173810010	173810010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tacccattttccagattataGatatcagtgatgtgtttaga	7	6	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:173810010G>C	uc001gjh.1	+	11	1437	c.1027G>C	c.(1027-1029)GAT>CAT	p.D343H		NM_018122	NP_060592	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	343					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			central_nervous_system(2)	2					L-Aspartic Acid(DB00128)	CCAGATTATAGATATCAGTGA	0.323													0	0	0	0.016723	0	12	175										C	173810010	G	C	173810010	3	2	126	1	0	0	0	0	1	0	0	0	4242	942	33	1	1069	1	DARS2	1	173810010	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1283491	173810010	75440611	48	37346										
ASTN1	460	broad.mit.edu	37	chr1	176913088	176913088	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctaggcattgattctccagGggcacagtggccaccacaag	11	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:176913088G>T	uc001glc.2	-	14	2528	c.2316C>A	c.(2314-2316)CCC>CCA	p.P772P	ASTN1_uc001glb.1_Silent_p.P772P|ASTN1_uc001gld.1_Silent_p.P772P|ASTN1_uc009wwx.1_Silent_p.P772P	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	780					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GATTCTCCAGGGGCACAGTGG	0.512													1	0	3.45872e-05	0.004007	4.48172e-05	17	47										T	176913088	G	T	176913088	2	4	126	1	0	0	0	0	0	0	0	1	1064	1219	43	4		4	ASTN1	1	176913088	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3103078	176913088	72337533	49	37347										
SOAT1	6646	broad.mit.edu	37	chr1	179310346	179310346	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcttccatggctttcttttCatgatcttccagattggagt	7	10	4	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:179310346C>T	uc001gml.2	+	7	744	c.681C>T	c.(679-681)TTC>TTT	p.F227F	SOAT1_uc010pni.1_Silent_p.F162F|SOAT1_uc001gmm.2_Silent_p.F169F|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Silent_p.F162F	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	227					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GCTTTCTTTTCATGATCTTCC	0.433													0	0	0	0.01441	0	57	256										T	179310346	C	T	179310346	2	4	126	1	0	0	0	0	0	0	0	1	14910	825	29	1		1	SOAT1	1	179310346	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2397258	179310346	69940275	50	37348										
MR1	3140	broad.mit.edu	37	chr1	181018405	181018405	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggggctggcagcagatgttCaaggtggaactgaagcgcct	16	8	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:181018405C>G	uc001goq.1	+	2	290	c.285C>G	c.(283-285)TTC>TTG	p.F95L	MR1_uc001gop.2_Missense_Mutation_p.F95L|MR1_uc001gor.1_Missense_Mutation_p.F95L|MR1_uc001gos.1_Missense_Mutation_p.F95L|MR1_uc010pns.1_Missense_Mutation_p.F95L	NM_001531	NP_001522	Q95460	HMR1_HUMAN	major histocompatibility complex, class	95	Extracellular (Potential).|Ligand-binding.|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|immune response	endoplasmic reticulum|extracellular region|integral to membrane|MHC class I protein complex	MHC class I receptor activity			skin(1)	1						AGCAGATGTTCAAGGTGGAAC	0.617													0	0	0	0.004482	0	8	44										G	181018405	C	G	181018405	3	3	126	1	0	0	0	0	1	0	0	0	9752	825	29	1	291	1	MR1	1	181018405	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1708059	181018405	68232216	51	37349										
NCF2	4688	broad.mit.edu	37	chr1	183532431	183532431	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caccagctcattgctgtcccGaggccgatagctgggtgggg	15	12	1	0	rs145970396		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:183532431G>A	uc001gqj.3	-	13	1464	c.1189C>T	c.(1189-1191)CGG>TGG	p.R397W	NCF2_uc010pod.1_Missense_Mutation_p.R352W|NCF2_uc010poe.1_Missense_Mutation_p.R316W|NCF2_uc001gqk.3_Missense_Mutation_p.R397W	NM_000433	NP_000424	P19878	NCF2_HUMAN	neutrophil cytosolic factor 2	397	OPR.				cellular defense response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex|nucleolus	electron carrier activity|protein C-terminus binding			ovary(3)	3						TTGCTGTCCCGAGGCCGATAG	0.522													0	0	0	0.010818	0	31	104										A	183532431	G	A	183532431	3	1	126	1	0	0	0	0	1	0	0	0	10217	1057	37	1	403	1	NCF2	1	183532431	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2514026	183532431	65718190	52	37350										
CAMSAP1L1	23271	broad.mit.edu	37	chr1	200824006	200824006	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagagtgtacattcaggcaaGaggacgccaaggtaaatcta	12	7	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:200824006G>C	uc001gvl.2	+	15	4188	c.3918G>C	c.(3916-3918)AAG>AAC	p.K1306N	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.K1295N|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.K1279N	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1306						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ATTCAGGCAAGAGGACGCCAA	0.343													0	0	0	0.001168	0	6	21										C	200824006	G	C	200824006	3	2	126	1	0	0	0	0	1	0	0	0	2612	933	33	1	3939	1	CAMSAP1L1	1	200824006	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	17291575	200824006	48426615	53	37351										
ATP2B4	493	broad.mit.edu	37	chr1	203678495	203678495	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccgagtgtgctctgctaggcTttgtcacagatctgaagcag	12	10	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:203678495T>G	uc001gzw.2	+	11	2508	c.1624T>G	c.(1624-1626)TTT>GTT	p.F542V	ATP2B4_uc001gzv.2_Missense_Mutation_p.F542V|ATP2B4_uc009xaq.2_Missense_Mutation_p.F542V	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	542	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCTGCTAGGCTTTGTCACAGA	0.512													0	0	0	0.013114	0	46	84										G	203678495	T	G	203678495	3	3	126	1	0	0	0	0	1	0	0	0	1142	1609	56	5	1662	5	ATP2B4	1	203678495	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	2854489	203678495	45572126	54	37352										
FAIM3	9214	broad.mit.edu	37	chr1	207087118	207087119	+	Frame_Shift_Ins	INS	-	-	G													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctaccactgtggacattcaINSgggtgactttctgggtcttt							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:207087118_207087119insG	uc001hey.2	-	2	537_538	c.358_359insC	c.(358-360)CTGfs	p.L120fs	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_Intron|FAIM3_uc010psb.1_Frame_Shift_Ins_p.L120fs	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	120	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					GTGGACATTCAGGGTGACTTTC	0.515																		24	116	---	---								G	207087119	-	G	207087118	7	5	126	1	0	1	1	0	0	0	0	0	5377	188	7	0	841	0	FAIM3	1	207087118	Frame_Shift_Ins	INS	-	TCGA-H4-A2HQ-01A-11D-A17V-08	3408623	207087118	42163503	55	37353										
FCAMR	83953	broad.mit.edu	37	chr1	207135777	207135777	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatccatcttgggggccccaGacggcaccagtacttcctct	10	15	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:207135777G>A	uc001hfa.3	-	5	933	c.433C>T	c.(433-435)CTG>TTG	p.L145L	FCAMR_uc001hfb.2_Silent_p.L145L|FCAMR_uc009xca.1_Silent_p.L145L|FCAMR_uc001hfc.2_Silent_p.L120L	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	100	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						GGGGGCCCCAGACGGCACCAG	0.577													0	0	0	0.004007	0	15	61										A	207135777	G	A	207135777	2	1	126	1	0	0	0	0	0	0	0	1	5772	933	33	1		1	FCAMR	1	207135777	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	48659	207135777	42114844	56	37354										
C4BPA	722	broad.mit.edu	37	chr1	207286412	207286412	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctggggctcttcatagaaaAaggaaaatggcagcctggcc	12	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:207286412A>C	uc001hfo.2	+	2	236	c.42A>C	c.(40-42)AAA>AAC	p.K14N		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	14					complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TTCATAGAAAAAGGAAAATGG	0.453													0	0	0	0.005443	0	27	29										C	207286412	A	C	207286412	3	2	126	1	0	0	0	0	1	0	0	0	2249	11	1	5	44	5	C4BPA	1	207286412	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	150635	207286412	41964209	57	37355										
CD34	947	broad.mit.edu	37	chr1	208072532	208072532	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtttgtgtttccataaactGaggttatcacagaggtagat	10	5	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:208072532G>C	uc001hgw.1	-	3	560	c.302C>G	c.(301-303)TCA>TGA	p.S101*	CD34_uc001hgx.1_Nonsense_Mutation_p.S101*|CD34_uc010psj.1_Intron	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	101	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						TCCATAAACTGAGGTTATCAC	0.448													0	0	0	0.007291	0	28	191										C	208072532	G	C	208072532	4	2	126	1	0	0	0	0	0	1	0	0	3006	1294	45	1	898	1	CD34	1	208072532	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	786120	208072532	41178089	58	37356										
USH2A	7399	broad.mit.edu	37	chr1	216052273	216052273	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccaaggtacccattacccccTgagcaagcaacaatggtgac	8	14	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:216052273T>A	uc001hku.1	-	42	8778	c.8391A>T	c.(8389-8391)TCA>TCT	p.S2797S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2797	Fibronectin type-III 14.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CATTACCCCCTGAGCAAGCAA	0.448										HNSCC(13;0.011)			0	0	0	0.010729	0	10	53										A	216052273	T	A	216052273	2	1	126	1	0	0	0	0	0	0	0	1	17033	1567	55	5		5	USH2A	1	216052273	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	7979741	216052273	33198348	59	37357										
TP53BP2	7159	broad.mit.edu	37	chr1	223976866	223976866	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gttacatgaggcagcacaatGtaatggagtcctgtgaagca	12	7	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:223976866G>A	uc010pvb.1	-	16	3299	c.3007C>T	c.(3007-3009)CAT>TAT	p.H1003Y	TP53BP2_uc001hod.2_Missense_Mutation_p.H874Y|TP53BP2_uc010puz.1_Missense_Mutation_p.H236Y|TP53BP2_uc010pva.1_Missense_Mutation_p.H642Y	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	997	ANK 2.|Mediates interaction with APC2.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCAGCACAATGTAATGGAGTC	0.458													0	0	0	0.012319	0	19	88										A	223976866	G	A	223976866	3	1	126	1	0	0	0	0	1	0	0	0	16381	1377	48	2	409	2	TP53BP2	1	223976866	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7924593	223976866	25273755	60	37358										
SIPA1L2	57568	broad.mit.edu	37	chr1	232596869	232596869	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggcccagcccgttcctcctCagggtcatttccacagtctc	8	17	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:232596869C>T	uc001hvg.2	-	8	3017	c.2859G>A	c.(2857-2859)CTG>CTA	p.L953L	SIPA1L2_uc001hvf.2_Silent_p.L27L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	953	PDZ.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CGTTCCTCCTCAGGGTCATTT	0.562													0	0	0	0.01441	0	93	199										T	232596869	C	T	232596869	2	4	126	1	0	0	0	0	0	0	0	1	14330	813	29	1		1	SIPA1L2	1	232596869	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8620003	232596869	16653752	61	37359										
SLC35F3	148641	broad.mit.edu	37	chr1	234452365	234452365	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagattgtggccgccatcctCgccatcgctggcattgtgat	11	13	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:234452365C>T	uc001hwa.1	+	4	867	c.639C>T	c.(637-639)CTC>CTT	p.L213L	SLC35F3_uc001hvy.1_Silent_p.L282L	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	213	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CCGCCATCCTCGCCATCGCTG	0.577													0	0	0	0.01441	0	228	429										T	234452365	C	T	234452365	2	4	126	1	0	0	0	0	0	0	0	1	14590	871	31	1		1	SLC35F3	1	234452365	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1855496	234452365	14798256	62	37360										
PLD5	200150	broad.mit.edu	37	chr1	242383316	242383316	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagggattgccagtccaaacCggcactgccgatatacacgt	10	13	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:242383316C>A	uc001hzn.1	-	5	836	c.709G>T	c.(709-711)GGT>TGT	p.G237C	PLD5_uc001hzl.3_Missense_Mutation_p.G175C|PLD5_uc001hzm.3_Missense_Mutation_p.G27C|PLD5_uc001hzo.1_Missense_Mutation_p.G145C			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	237	PLD phosphodiesterase 1.					integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			CAGTCCAAACCGGCACTGCCG	0.517													1	0	0.000602214	0.014758	0.000762437	5	43										A	242383316	C	A	242383316	3	1	126	1	0	0	0	0	1	0	0	0	12049	652	23	4	925	4	PLD5	1	242383316	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7930951	242383316	6867305	63	37361										
ZNF124	7678	broad.mit.edu	37	chr1	247323035	247323035	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcctgcatcacgtctctataGagattcttctgggaaggatc	9	10	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:247323035G>C	uc001ick.2	-	2	250	c.111C>G	c.(109-111)CTC>CTG	p.L37L	ZNF124_uc001ici.2_RNA|ZNF124_uc001icj.1_Silent_p.L37L	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CGTCTCTATAGAGATTCTTCT	0.418													0	0	0	0.013726	0	33	61										C	247323035	G	C	247323035	2	2	126	1	0	0	0	0	0	0	0	1	17717	929	33	1		1	ZNF124	1	247323035	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4939719	247323035	1927586	64	37362										
OR2AK2	391191	broad.mit.edu	37	chr1	248129260	248129260	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgtgtcaggacacctcccaGtatgagtatacagtcctcct	9	12	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr1:248129260G>A	uc010pzd.1	+	1	627	c.627G>A	c.(625-627)CAG>CAA	p.Q209Q	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	209	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ACACCTCCCAGTATGAGTATA	0.443													0	0	0	0.004007	0	17	28										A	248129260	G	A	248129260	2	1	126	1	0	0	0	0	0	0	0	1	10986	1020	36	2		2	OR2AK2	1	248129260	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	806225	248129260	1121361	65	37363										
TPO	7173	broad.mit.edu	37	chr2	1481320	1481320	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcaaggccctcaatgcgcacTggagcgcggacgccgtgtac	13	14	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:1481320T>A	uc002qww.2	+	8	1373	c.1282T>A	c.(1282-1284)TGG>AGG	p.W428R	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.W428R|TPO_uc002qwr.2_Missense_Mutation_p.W428R|TPO_uc002qwx.2_Missense_Mutation_p.W428R|TPO_uc010yio.1_Intron|TPO_uc010yip.1_Missense_Mutation_p.W428R	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	428	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAATGCGCACTGGAGCGCGGA	0.741													0	0	0	0.00308	0	7	9										A	1481320	T	A	1481320	3	1	126	1	0	0	0	0	1	0	0	0	16407	1580	55	5	1308	5	TPO	2	1481320	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08		1481320	241718053	66	37364										
C2orf44	80304	broad.mit.edu	37	chr2	24261333	24261333	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctttaagattaaatgctatCagatcaggaaccagaatgcc	8	8	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:24261333C>G	uc002rep.2	-	2	1163	c.1032G>C	c.(1030-1032)CTG>CTC	p.L344L	C2orf44_uc010eya.2_Silent_p.L344L	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	344							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAAATGCTATCAGATCAGGAA	0.418													0	0	0	0.009096	0	4	93										G	24261333	C	G	24261333	2	3	126	1	0	0	0	0	0	0	0	1	2168	813	29	1		1	C2orf44	2	24261333	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	22780013	24261333	218938040	67	37365										
ADCY3	109	broad.mit.edu	37	chr2	25141819	25141819	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actcggctgagtactcggccGagtattcgggctcggagaag	15	10	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:25141819G>A	uc002rfs.3	-	1	237	c.38C>T	c.(37-39)TCG>TTG	p.S13L	ADCY3_uc010ykm.1_Missense_Mutation_p.S13L	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	13	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					gtactcggccgagtattcggG	0.542													0	0	0	0.014758	0	4	21										A	25141819	G	A	25141819	3	1	126	1	0	0	0	0	1	0	0	0	295	1059	37	1	3480	1	ADCY3	2	25141819	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	880486	25141819	218057554	68	37366										
OTOF	9381	broad.mit.edu	37	chr2	26706369	26706369	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acttgcacgtaggggtccacGaggtccttgttttcaccgat	11	11	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:26706369G>C	uc002rhk.2	-	13	1480	c.1353C>G	c.(1351-1353)CTC>CTG	p.L451L		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	451	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGGGTCCACGAGGTCCTTGT	0.537													0	0	0	0.003163	0	15	92										C	26706369	G	C	26706369	2	2	126	1	0	0	0	0	0	0	0	1	11303	1045	37	1		1	OTOF	2	26706369	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1564550	26706369	216493004	69	37367										
C2orf16	84226	broad.mit.edu	37	chr2	27804486	27804486	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggagccatcgcggtccctcaGagagaagccattgcagtccc	12	14	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:27804486G>C	uc002rkz.3	+	1	5098	c.5047G>C	c.(5047-5049)GAG>CAG	p.E1683Q	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1683	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.|7.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CGGTCCCTCAGAGAGAAGCCA	0.567													0	0	0	0.010729	0	11	342										C	27804486	G	C	27804486	3	2	126	1	0	0	0	0	1	0	0	0	2157	943	33	1	5049	1	C2orf16	2	27804486	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1098117	27804486	215394887	70	37368										
BIRC6	57448	broad.mit.edu	37	chr2	32743962	32743962	+	Missense_Mutation	SNP	C	C	T													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caggccacaaattccgtactCttcatttgccagtctcaaca							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:32743962C>T	uc010ezu.2	+	57	11706	c.11572C>T	c.(11572-11574)CTT>TTT	p.L3858F		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3858					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATTCCGTACTCTTCATTTGCC	0.368													0	0	0	0.004482	0	7	36										T	32743962	C	T	32743962	3	4	126	1	0	0	0	0	1	0	0	0	1438	913	32	1	11798	1	BIRC6	2	32743962	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4939476	32743962	210455411	71	37369	194	2								
BIRC6	57448	broad.mit.edu	37	chr2	32743965	32743965	+	Missense_Mutation	SNP	C	C	T													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccacaaattccgtactcttCatttgccagtctcaacaaca							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:32743965C>T	uc010ezu.2	+	57	11709	c.11575C>T	c.(11575-11577)CAT>TAT	p.H3859Y		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3859					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CCGTACTCTTCATTTGCCAGT	0.363													0	0	0	0.004482	0	7	36										T	32743965	C	T	32743965	3	4	126	1	0	0	0	0	1	0	0	0	1438	826	29	1	11801	1	BIRC6	2	32743965	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3	32743965	210455408	72	37370	194	2								
BIRC6	57448	broad.mit.edu	37	chr2	32743998	32743998	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caacaacattatcagatgttCttgacagagtgtcaggcaag	9	8	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:32743998C>G	uc010ezu.2	+	57	11742	c.11608C>G	c.(11608-11610)CTT>GTT	p.L3870V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3870					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATCAGATGTTCTTGACAGAGT	0.348													0	0	0	0.014758	0	5	27										G	32743998	C	G	32743998	3	3	126	1	0	0	0	0	1	0	0	0	1438	913	32	1	11834	1	BIRC6	2	32743998	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	33	32743998	210455375	73	37371										
PRKD3	23683	broad.mit.edu	37	chr2	37505009	37505009	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaatgtatttgattactgacCaggttatccctgctggtgta	9	7	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:37505009C>G	uc002rqd.2	-	8	1851	c.1296G>C	c.(1294-1296)CTG>CTC	p.L432L	PRKD3_uc002rqe.1_Silent_p.L32L|PRKD3_uc002rqf.1_Silent_p.L432L	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	432	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				GATTACTGACCAGGTTATCCC	0.378													0	0	0	0.005524	0	36	83										G	37505009	C	G	37505009	2	3	126	1	0	0	0	0	0	0	0	1	12520	608	21	4		4	PRKD3	2	37505009	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4761011	37505009	205694364	74	37372										
PLEKHH2	130271	broad.mit.edu	37	chr2	43953483	43953483	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatcttgtgattcagatgaaGattatgaagccagtggacga	12	5	2	5			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:43953483G>C	uc010yny.1	+	17	2697	c.2614G>C	c.(2614-2616)GAT>CAT	p.D872H	PLEKHH2_uc002rtf.3_Missense_Mutation_p.D871H	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	872	PH 2.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTCAGATGAAGATTATGAAGC	0.398													0	0	0	0.004672	0	3	51										C	43953483	G	C	43953483	3	2	126	1	0	0	0	0	1	0	0	0	12077	942	33	1	2676	1	PLEKHH2	2	43953483	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6448474	43953483	199245890	75	37373										
SIX3	6496	broad.mit.edu	37	chr2	45171878	45171878	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atcctctcggtaacctccagCgactcggaatgtgatgtatg	10	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:45171878C>G	uc002run.1	+	2	1185	c.978C>G	c.(976-978)AGC>AGG	p.S326R		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	326					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TAACCTCCAGCGACTCGGAAT	0.448													0	0	0	0.009096	0	3	9										G	45171878	C	G	45171878	3	3	126	1	0	0	0	0	1	0	0	0	14348	767	27	4	984	4	SIX3	2	45171878	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1218395	45171878	198027495	76	37374										
PAIP2B	400961	broad.mit.edu	37	chr2	71415650	71415650	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaactccttggcatctgggtTcaggttacttttgctctgaa	9	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:71415650T>C	uc002shu.2	-	4	518	c.331A>G	c.(331-333)AAC>GAC	p.N111D		NM_020459	NP_065192	Q9ULR5	PAI2B_HUMAN	poly(A) binding protein interacting protein 2B	111					negative regulation of translational initiation		protein binding|translation repressor activity, nucleic acid binding				0						GCATCTGGGTTCAGGTTACTT	0.433													0	0	0	0.004672	0	3	21										C	71415650	T	C	71415650	3	2	126	1	0	0	0	0	1	0	0	0	11398	1783	62	5	44	5	PAIP2B	2	71415650	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	26243772	71415650	171783723	77	37375										
RAB11FIP5	26056	broad.mit.edu	37	chr2	73316194	73316194	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagcctttggctttgcccatCttgcccaggctgcccaggtc	10	15	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:73316194C>G	uc002siu.3	-	2	922	c.681G>C	c.(679-681)AAG>AAC	p.K227N	RAB11FIP5_uc002sit.3_Missense_Mutation_p.K149N	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	227					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CTTTGCCCATCTTGCCCAGGC	0.587													0	0	0	0.009535	0	31	134										G	73316194	C	G	73316194	3	3	126	1	0	0	0	0	1	0	0	0	12897	912	32	1	1296	1	RAB11FIP5	2	73316194	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1900544	73316194	169883179	78	37376										
SEMA4F	10505	broad.mit.edu	37	chr2	74900804	74900804	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaggccactggtattcccagCcccagcctttgtcgcagccg	11	16	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:74900804C>T	uc002sna.1	+	7	782	c.671C>T	c.(670-672)GCC>GTC	p.A224V	SEMA4F_uc010ysb.1_3'UTR|SEMA4F_uc010ffq.1_Missense_Mutation_p.A191V|SEMA4F_uc010ffr.1_Intron|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	224	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTATTCCCAGCCCCAGCCTTT	0.592													0	0	0	0.005443	0	28	57										T	74900804	C	T	74900804	3	4	126	1	0	0	0	0	1	0	0	0	14035	753	26	2	697	2	SEMA4F	2	74900804	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1584610	74900804	168298569	79	37377										
TACR1	6869	broad.mit.edu	37	chr2	75425676	75425676	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caaaggctaatctcacctatCaaaggccacagccgtcatgg	8	13	3	0	rs77755890		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:75425676C>G	uc002sng.2	-	1	970	c.385G>C	c.(385-387)GAT>CAT	p.D129H	TACR1_uc002snh.2_Missense_Mutation_p.D129H	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	129	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TCTCACCTATCAAAGGCCACA	0.512													0	0	0	0.001984	0	7	103										G	75425676	C	G	75425676	3	3	126	1	0	0	0	0	1	0	0	0	15502	826	29	1	862	1	TACR1	2	75425676	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	524872	75425676	167773697	80	37378										
REG1A	5967	broad.mit.edu	37	chr2	79347991	79347991	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attcattgcagctcagcatgGctcagaccagctcatacttc	7	13	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:79347991G>T	uc002snz.2	+	2	107	c.4G>T	c.(4-6)GCT>TCT	p.A2S	REG1A_uc010ffx.1_Missense_Mutation_p.A2S|REG1A_uc010ysd.1_Missense_Mutation_p.A2S	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	2					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GCTCAGCATGGCTCAGACCAG	0.473													1	0	5.9392e-07	0.001168	7.88086e-07	5	48										T	79347991	G	T	79347991	3	4	126	1	0	0	0	0	1	0	0	0	13210	1203	42	4	6	4	REG1A	2	79347991	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3922315	79347991	163851382	81	37379										
POLR1A	25885	broad.mit.edu	37	chr2	86280076	86280076	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	taggcggagctcccatagtgCgccttgtccagcactccgca	11	15	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:86280076C>T	uc002sqs.2	-	16	2635	c.2256G>A	c.(2254-2256)GCG>GCA	p.A752A	POLR1A_uc010ytb.1_Silent_p.A118A	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	752					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TCCCATAGTGCGCCTTGTCCA	0.632													0	0	0	0.007291	0	28	39										T	86280076	C	T	86280076	2	4	126	1	0	0	0	0	0	0	0	1	12209	755	27	2		2	POLR1A	2	86280076	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6932085	86280076	156919297	82	37380										
RPIA	22934	broad.mit.edu	37	chr2	89034118	89034118	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtagatgctgatctcaatcTcatcaagggtggcgggtgag	14	7	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:89034118T>C	uc002ste.2	+	5	553	c.512T>C	c.(511-513)CTC>CCC	p.L171P		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	171					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				GATCTCAATCTCATCAAGGGT	0.448													0	0	0	0.009535	0	31	62										C	89034118	T	C	89034118	3	2	126	1	0	0	0	0	1	0	0	0	13553	1551	54	5	530	5	RPIA	2	89034118	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	2754042	89034118	154165255	83	37381										
GPAT2	150763	broad.mit.edu	37	chr2	96687951	96687951	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaactgttctagtttttcctGattgtccaggctggcaaaag	10	8	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:96687951G>C	uc002svf.2	-	22	2567	c.2344C>G	c.(2344-2346)CAG>GAG	p.Q782E	LOC729234_uc010fht.2_Intron|GPAT2_uc002svd.2_Missense_Mutation_p.Q601E|GPAT2_uc002sve.2_Missense_Mutation_p.Q584E|GPAT2_uc002svg.2_Missense_Mutation_p.Q661E|GPAT2_uc010yuh.1_Missense_Mutation_p.Q711E|GPAT2_uc002svh.2_3'UTR	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	782					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						AGTTTTTCCTGATTGTCCAGG	0.562													0	0	0	0.008871	0	16	25										C	96687951	G	C	96687951	3	2	126	1	0	0	0	0	1	0	0	0	6589	1299	45	1	47	1	GPAT2	2	96687951	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7653833	96687951	146511422	84	37382										
REV1	51455	broad.mit.edu	37	chr2	100020219	100020219	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgcctttgtctttgatcataCgctgctttcagctccctctg	7	13	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:100020219C>T	uc002tad.2	-	19	3317	c.3105G>A	c.(3103-3105)GCG>GCA	p.A1035A	REV1_uc002tac.2_Silent_p.A1034A	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	1035					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding	p.A1035A(1)		ovary(2)	2						TTTGATCATACGCTGCTTTCA	0.498								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	54	70										T	100020219	C	T	100020219	2	4	126	1	0	0	0	0	0	0	0	1	13239	523	19	2		2	REV1	2	100020219	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3332268	100020219	143179154	85	37383										
IL18R1	8809	broad.mit.edu	37	chr2	102984374	102984374	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gttcacttgcacatgagattGaaacaaccaccaaaagctgg	8	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:102984374G>A	uc002tbw.3	+	3	298	c.148G>A	c.(148-150)GAA>AAA	p.E50K	IL18R1_uc010ywb.1_Missense_Mutation_p.E50K|IL18R1_uc010ywc.1_Missense_Mutation_p.E50K|IL18R1_uc010ywd.1_Intron|IL18R1_uc010fiy.2_Missense_Mutation_p.E50K	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	50	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity	p.E50K(1)		ovary(2)|pancreas(1)	3						ACATGAGATTGAAACAACCAC	0.428													0	0	0	0.009096	0	4	45										A	102984374	G	A	102984374	3	1	126	1	0	0	0	0	1	0	0	0	7647	1291	45	1	154	1	IL18R1	2	102984374	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2964155	102984374	140214999	86	37384										
SLC9A4	389015	broad.mit.edu	37	chr2	103119941	103119941	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gttaattgcctttacaaagaTgcataaatttgaagacatag	7	5	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:103119941T>G	uc002tbz.3	+	3	1212	c.755T>G	c.(754-756)ATG>AGG	p.M252R		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	252	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						TTTACAAAGATGCATAAATTT	0.373													0	0	0	0.014758	0	5	31										G	103119941	T	G	103119941	3	3	126	1	0	0	0	0	1	0	0	0	14716	1464	51	5	765	5	SLC9A4	2	103119941	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	135567	103119941	140079432	87	37385										
GCC2	9648	broad.mit.edu	37	chr2	109087478	109087478	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaaataccataaagaaccttCaagaaaagaatggagtatac	6	6	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:109087478C>T	uc002tec.2	+	6	1847	c.1693C>T	c.(1693-1695)CAA>TAA	p.Q565*	GCC2_uc002ted.2_Nonsense_Mutation_p.Q464*	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	565	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAAGAACCTTCAAGAAAAGAA	0.204													0	0	0	0.001984	0	7	29										T	109087478	C	T	109087478	4	4	126	1	0	0	0	0	0	1	0	0	6286	827	29	1	1715	1	GCC2	2	109087478	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	5967537	109087478	134111895	88	37386										
UGGT1	56886	broad.mit.edu	37	chr2	128913070	128913070	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttttttctcccagataacttCtttgtggatgattatgctag	7	7	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:128913070C>T	uc002tps.2	+	20	2323	c.2145C>T	c.(2143-2145)TTC>TTT	p.F715F	UGGT1_uc010fme.1_Silent_p.F590F|UGGT1_uc002tpr.2_Silent_p.F691F	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	715					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						CAGATAACTTCTTTGTGGATG	0.323													0	0	0	0.001168	0	6	42										T	128913070	C	T	128913070	2	4	126	1	0	0	0	0	0	0	0	1	16938	912	32	1		1	UGGT1	2	128913070	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	19825592	128913070	114286303	89	37387										
NXPH2	11249	broad.mit.edu	37	chr2	139428601	139428601	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caatgtaaatgcaaatgaccTtgaagggcttggagcacaac	10	8	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:139428601T>C	uc002tvi.2	-	2	686	c.686A>G	c.(685-687)AAG>AGG	p.K229R		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	229	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		GCAAATGACCTTGAAGGGCTT	0.468													0	0	0	0.010504	0	21	16										C	139428601	T	C	139428601	3	2	126	1	0	0	0	0	1	0	0	0	10791	1609	56	5	112	5	NXPH2	2	139428601	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	10515531	139428601	103770772	90	37388										
LRP1B	53353	broad.mit.edu	37	chr2	141806780	141806780	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccataaaagaggaacaactCattctttggtcctgcagagg	9	10	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:141806780C>G	uc002tvj.1	-	11	2536	c.1564G>C	c.(1564-1566)GAG>CAG	p.E522Q	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	522	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGAACAACTCATTCTTTGGT	0.398										TSP Lung(27;0.18)			0	0	0	0.008291	0	10	21										G	141806780	C	G	141806780	3	3	126	1	0	0	0	0	1	0	0	0	8955	835	29	1	12559	1	LRP1B	2	141806780	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2378179	141806780	101392593	91	37389										
BAZ2B	29994	broad.mit.edu	37	chr2	160194090	160194090	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcagataccttctttcaatgTtccgctccaaatcagccagc	5	14	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:160194090T>A	uc002uao.2	-	32	6000	c.5648A>T	c.(5647-5649)AAC>ATC	p.N1883I	BAZ2B_uc002uap.2_Missense_Mutation_p.N1847I	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1883					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TCTTTCAATGTTCCGCTCCAA	0.483													0	0	0	0.015359	0	35	89										A	160194090	T	A	160194090	3	1	126	1	0	0	0	0	1	0	0	0	1332	1725	60	5	882	5	BAZ2B	2	160194090	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	18387310	160194090	83005283	92	37390										
BAZ2B	29994	broad.mit.edu	37	chr2	160206576	160206576	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccagtgaatgttttccactGttctgataagacaacgtgca	8	10	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:160206576G>C	uc002uao.2	-	28	4858	c.4506C>G	c.(4504-4506)AAC>AAG	p.N1502K	BAZ2B_uc002uap.2_Missense_Mutation_p.N1466K	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						GTTTTCCACTGTTCTGATAAG	0.448													0	0	0	0.004007	0	17	43										C	160206576	G	C	160206576	3	2	126	1	0	0	0	0	1	0	0	0	1332	1368	48	4	2040	4	BAZ2B	2	160206576	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	12486	160206576	82992797	93	37391										
SCN1A	6323	broad.mit.edu	37	chr2	166850897	166850897	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcaaaaacttgtctggttacGaagtcaaagaccattccttg	7	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:166850897G>T	uc010zcz.1	-	25	4596	c.4578C>A	c.(4576-4578)TTC>TTA	p.F1526L		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1537	Helical; Name=S1 of repeat IV; (By similarity).|IV.			F -> L (in Ref. 7; CAA46439/M91803).		voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTCTGGTTACGAAGTCAAAGA	0.353													1	0	1.23904e-05	0.014758	1.61056e-05	4	10										T	166850897	G	T	166850897	3	4	126	1	0	0	0	0	1	0	0	0	13914	1049	37	3	1426	3	SCN1A	2	166850897	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6644321	166850897	76348476	94	37392										
XIRP2	129446	broad.mit.edu	37	chr2	168105339	168105339	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaacacacggagacaaagcaGaacgttattagtaagagtct	10	7	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:168105339G>A	uc002udx.2	+	8	7455	c.7437G>A	c.(7435-7437)CAG>CAA	p.Q2479Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.Q2304Q|XIRP2_uc010fpq.2_Silent_p.Q2257Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2304					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGACAAAGCAGAACGTTATTA	0.403													0	0	0	0.013537	0	13	15										A	168105339	G	A	168105339	2	1	126	1	0	0	0	0	0	0	0	1	17427	933	33	1		1	XIRP2	2	168105339	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1254442	168105339	75094034	95	37393										
LRP2	4036	broad.mit.edu	37	chr2	170019001	170019001	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgcaacccagttcatcggaCcagtcaccacagtcatcggc	8	16	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:170019001C>A	uc002ues.2	-	63	12081	c.11868G>T	c.(11866-11868)TGG>TGT	p.W3956C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3956	LDL-receptor class A 36.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTTCATCGGACCAGTCACCAC	0.388													1	0	3.65163e-15	0.00632	5.03086e-15	27	47										A	170019001	C	A	170019001	3	1	126	1	0	0	0	0	1	0	0	0	8956	508	18	4	2167	4	LRP2	2	170019001	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1913662	170019001	73180372	96	37394										
SLC25A12	8604	broad.mit.edu	37	chr2	172749752	172749752	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttaactcatgaggatcccctCgcttagttgtctgcacctgt	8	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:172749752C>T	uc002uhh.2	-	2	118	c.29G>A	c.(28-30)CGA>CAA	p.R10Q	SLC25A12_uc010fqh.2_5'UTR|SLC25A12_uc010zdv.1_RNA	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	10					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	AGGATCCCCTCGCTTAGTTGT	0.393													0	0	0	0.008361	0	27	133										T	172749752	C	T	172749752	3	4	126	1	0	0	0	0	1	0	0	0	14474	884	31	1	2075	1	SLC25A12	2	172749752	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2730751	172749752	70449621	97	37395										
TTN	7273	broad.mit.edu	37	chr2	179399173	179399173	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtcatgcgagatttcctctCtttcactaacaaccggtcaa	6	12	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179399173C>A	uc010zfg.1	-	307	94689	c.94465G>T	c.(94465-94467)GAG>TAG	p.E31489*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.E25184*|TTN_uc010zfi.1_Nonsense_Mutation_p.E25117*|TTN_uc010zfj.1_Nonsense_Mutation_p.E24992*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32416							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTTCCTCTCTTTCACTAAC	0.398													1	0	1.26454e-06	0.005443	1.67527e-06	25	98										A	179399173	C	A	179399173	4	1	126	1	0	0	0	0	0	1	0	0	16732	922	32	3	5830	3	TTN	2	179399173	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6649421	179399173	63800200	98	37396										
TTN	7273	broad.mit.edu	37	chr2	179444828	179444828	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agaccaggatttcctctctgCatcacgtttttgtaccacat	6	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179444828C>G	uc010zfg.1	-	267	59706	c.59482G>C	c.(59482-59484)GCA>CCA	p.A19828P	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.A13523P|TTN_uc010zfi.1_Missense_Mutation_p.A13456P|TTN_uc010zfj.1_Missense_Mutation_p.A13331P|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20755							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTCTCTGCATCACGTTTT	0.438													0	0	0	0.003163	0	15	106										G	179444828	C	G	179444828	3	3	126	1	0	0	0	0	1	0	0	0	16732	710	25	4	40973	4	TTN	2	179444828	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	45655	179444828	63754545	99	37397										
TTN	7273	broad.mit.edu	37	chr2	179578817	179578817	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacttagtactgagttcaggGgtgccagctactgtacactc	10	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179578817G>C	uc010zfg.1	-	89	23060	c.22836C>G	c.(22834-22836)ACC>ACG	p.T7612T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T4273T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8539							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGTTCAGGGGTGCCAGCTA	0.413													0	0	0	0.013537	0	13	17										C	179578817	G	C	179578817	2	2	126	1	0	0	0	0	0	0	0	1	16732	1219	43	4		4	TTN	2	179578817	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	133989	179578817	63620556	100	37398										
TTN	7273	broad.mit.edu	37	chr2	179579153	179579153	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttctgaataagaaatccatAtgttgtcactttctctaacg	5	8	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179579153A>G	uc010zfg.1	-	88	22840	c.22616T>C	c.(22615-22617)ATA>ACA	p.I7539T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I4200T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8466							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAATCCATATGTTGTCACT	0.413													0	0	0	0.004007	0	17	23										G	179579153	A	G	179579153	3	3	126	1	0	0	0	0	1	0	0	0	16732	449	16	5	78269	5	TTN	2	179579153	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	336	179579153	63620220	101	37399										
TTN	7273	broad.mit.edu	37	chr2	179642507	179642507	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctggcagtttgcccttctaaAcatttgaaagaaacaggttt	8	8	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:179642507A>C	uc010zfg.1	-	25	4628	c.4404T>G	c.(4402-4404)TGT>TGG	p.C1468W	TTN_uc010zfh.1_Missense_Mutation_p.C1422W|TTN_uc010zfi.1_Missense_Mutation_p.C1422W|TTN_uc010zfj.1_Missense_Mutation_p.C1422W|TTN_uc002unb.2_Missense_Mutation_p.C1468W|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1468							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCCTTCTAAACATTTGAAAG	0.418													0	0	0	0.013537	0	12	59										C	179642507	A	C	179642507	3	2	126	1	0	0	0	0	1	0	0	0	16732	41	2	5	106936	5	TTN	2	179642507	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	63354	179642507	63556866	102	37400										
DNAH7	56171	broad.mit.edu	37	chr2	196602713	196602713	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttccttgggttggtcagaggGaagagtcatggcaatcacaa	13	7	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:196602713G>A	uc002utj.3	-	65	12108	c.12007C>T	c.(12007-12009)CCC>TCC	p.P4003S	DNAH7_uc002uti.3_Missense_Mutation_p.P486S	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	4003					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGGTCAGAGGGAAGAGTCATG	0.438													0	0	0	0.00308	0	7	41										A	196602713	G	A	196602713	3	1	126	1	0	0	0	0	1	0	0	0	4606	1174	41	1	71	1	DNAH7	2	196602713	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	16960206	196602713	46596660	103	37401										
CFLAR	8837	broad.mit.edu	37	chr2	202000716	202000716	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtttcttggaccttgtggttGagttggagaaactaaatctg	12	5	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:202000716G>A	uc002uxb.3	+	4	861	c.409G>A	c.(409-411)GAG>AAG	p.E137K	CFLAR_uc002uwy.2_Missense_Mutation_p.E137K|CFLAR_uc002uwz.2_Missense_Mutation_p.E137K|CFLAR_uc002uxa.3_Missense_Mutation_p.E137K|CFLAR_uc010zhk.1_Missense_Mutation_p.E41K|CFLAR_uc002uxc.3_Missense_Mutation_p.E137K|CFLAR_uc010zhl.1_Missense_Mutation_p.E41K|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Missense_Mutation_p.E137K|CFLAR_uc002uxe.2_Missense_Mutation_p.E137K|CFLAR_uc002uxf.2_Missense_Mutation_p.E137K|CFLAR_uc010fsy.2_RNA|CFLAR_uc010fsx.2_Missense_Mutation_p.E137K|CFLAR_uc010zhm.1_Missense_Mutation_p.E41K|CFLAR_uc010fsz.2_5'UTR	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	137	Interaction with FADD.|Interaction with caspase-8.|DED 2.|Not proteolytically processed and involved in apoptosis inhibition.|Interaction with caspase-8 propeptide.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						CCTTGTGGTTGAGTTGGAGAA	0.313													0	0	0	0.008361	0	28	139										A	202000716	G	A	202000716	3	1	126	1	0	0	0	0	1	0	0	0	3292	1291	45	1	419	1	CFLAR	2	202000716	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5398003	202000716	41198657	104	37402										
BMPR2	659	broad.mit.edu	37	chr2	203420499	203420499	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccactgagcagtactagttCtagcttgctttacccactca	6	14	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:203420499C>G	uc002uzf.3	+	12	3259	c.2111C>G	c.(2110-2112)TCT>TGT	p.S704C	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	704	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AGTACTAGTTCTAGCTTGCTT	0.443													0	0	0	0.009096	0	4	102										G	203420499	C	G	203420499	3	3	126	1	0	0	0	0	1	0	0	0	1471	913	32	1	2157	1	BMPR2	2	203420499	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1419783	203420499	39778874	105	37403										
ABCA12	26154	broad.mit.edu	37	chr2	215851389	215851389	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctttgtgaccccatgcaggGcaaccccgactgtgagatct	10	13	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:215851389G>A	uc002vew.2	-	28	4260	c.4040C>T	c.(4039-4041)GCC>GTC	p.A1347V	ABCA12_uc002vev.2_Missense_Mutation_p.A1029V|ABCA12_uc010zjn.1_Missense_Mutation_p.A274V	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1347	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CCCATGCAGGGCAACCCCGAC	0.438													0	0	0	0.014758	0	4	64										A	215851389	G	A	215851389	3	1	126	1	0	0	0	0	1	0	0	0	30	1203	42	2	3851	2	ABCA12	2	215851389	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	12430890	215851389	27347984	106	37404										
STK36	27148	broad.mit.edu	37	chr2	219559043	219559043	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tacccattcgcatgtcgtctCtcttgtggtaagtttttaac	7	10	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:219559043C>T	uc002viu.2	+	20	2659	c.2393C>T	c.(2392-2394)TCT>TTT	p.S798F	STK36_uc002viv.2_Missense_Mutation_p.S798F|STK36_uc002viw.2_5'Flank|STK36_uc002vix.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	798					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CATGTCGTCTCTCTTGTGGTA	0.458													0	0	0	0.008291	0	8	195										T	219559043	C	T	219559043	3	4	126	1	0	0	0	0	1	0	0	0	15301	913	32	1	2467	1	STK36	2	219559043	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3707654	219559043	23640330	107	37405										
COL4A3	1285	broad.mit.edu	37	chr2	228148486	228148486	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttaatttgtttccataggtgAagatggagtgattgggatga	13	2	0	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:228148486A>T	uc002vom.1	+	33	2822	c.2660A>T	c.(2659-2661)GAA>GTA	p.E887V	COL4A3_uc002von.1_Missense_Mutation_p.E887V|COL4A3_uc002voo.1_Missense_Mutation_p.E887V|COL4A3_uc002vop.1_Missense_Mutation_p.E887V|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	887	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TCCATAGGTGAAGATGGAGTG	0.458													0	0	0	0.009718	0	40	111										T	228148486	A	T	228148486	3	4	126	1	0	0	0	0	1	0	0	0	3691	246	9	5	2790	5	COL4A3	2	228148486	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	8589443	228148486	15050887	108	37406										
SPHKAP	80309	broad.mit.edu	37	chr2	228881823	228881823	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttgatgggcacattcactgtCagcctggagcatggggatct	13	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:228881823C>T	uc002vpq.2	-	7	3794	c.3747G>A	c.(3745-3747)CTG>CTA	p.L1249L	SPHKAP_uc002vpp.2_Silent_p.L1249L|SPHKAP_uc010zlx.1_Silent_p.L1249L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1249						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATTCACTGTCAGCCTGGAGC	0.567													0	0	0	0.016723	0	13	91										T	228881823	C	T	228881823	2	4	126	1	0	0	0	0	0	0	0	1	15047	813	29	1		1	SPHKAP	2	228881823	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	733337	228881823	14317550	109	37407										
SPHKAP	80309	broad.mit.edu	37	chr2	228882099	228882099	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atggctgagttcagaatgctGctggcgttcttgccagcata	12	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr2:228882099G>C	uc002vpq.2	-	7	3518	c.3471C>G	c.(3469-3471)AGC>AGG	p.S1157R	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1157R|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1157R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1157						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCAGAATGCTGCTGGCGTTCT	0.512													0	0	0	0.008291	0	11	79										C	228882099	G	C	228882099	3	2	126	1	0	0	0	0	1	0	0	0	15047	1310	46	4	1655	4	SPHKAP	2	228882099	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	276	228882099	14317274	110	37408										
CHL1	10752	broad.mit.edu	37	chr3	424356	424356	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgaaacaccaccagcaggTatgcaggttctcacatcagg	9	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:424356T>A	uc003bou.2	+	17	2399	c.2128_splice	c.e17+2	p.A710_splice	CHL1_uc003bot.2_Splice_Site_p.A726_splice|CHL1_uc003bow.1_Splice_Site_p.A710_splice|CHL1_uc011asi.1_Splice_Site_p.A726_splice|uc003box.1_RNA	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CACCAGCAGGTATGCAGGTTC	0.413													0	0	0	0.00308	0	7	14										A	424356	T	A	424356	5	1	126	1	0	0	0	0	0	0	1	0	3349	1652	57	5	2240	5	CHL1	3	424356	Splice_Site	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08		424356	197598074	111	37409										
ITPR1	3708	broad.mit.edu	37	chr3	4715070	4715070	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctcggagatcgccattgacGagtgagcctggcacctgaaa	12	12	0	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:4715070G>A	uc003bqa.2	+	21	2803	c.2455G>A	c.(2455-2457)GAC>AAC	p.D819N	ITPR1_uc010hca.1_Missense_Mutation_p.D804N|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.D804N	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	819	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CGCCATTGACGAGTGAGCCTG	0.498													0	0	0	0.010818	0	27	141										A	4715070	G	A	4715070	3	1	126	1	0	0	0	0	1	0	0	0	7920	1072	37	1	2529	1	ITPR1	3	4715070	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4290714	4715070	193307360	112	37410										
BRPF1	7862	broad.mit.edu	37	chr3	9783835	9783835	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgagccggtccctctgtctGaggtaaccgaattggacgaa	13	11	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:9783835G>A	uc003bse.2	+	6	2380	c.1981G>A	c.(1981-1983)GAG>AAG	p.E661K	BRPF1_uc003bsf.2_Missense_Mutation_p.E661K|BRPF1_uc003bsg.2_Missense_Mutation_p.E661K|BRPF1_uc011ati.1_Missense_Mutation_p.E661K	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	661	Required for RUNX1 and RUNX2 transcriptional activation.|Interaction with MEAF6 and ING5.|Bromo.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					CCCTCTGTCTGAGGTAACCGA	0.557													0	0	0	0.014323	0	21	89										A	9783835	G	A	9783835	3	1	126	1	0	0	0	0	1	0	0	0	1520	1291	45	1	1999	1	BRPF1	3	9783835	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5068765	9783835	188238595	113	37411										
JAGN1	84522	broad.mit.edu	37	chr3	9934620	9934620	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgactctcaagtatgaaatCaagaagctgatctacgtaca	8	8	3	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:9934620C>G	uc003btt.3	+	2	247	c.111C>G	c.(109-111)ATC>ATG	p.I37M	CIDEC_uc003bto.2_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1	37	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(1)	1	Medulloblastoma(99;0.227)					AGTATGAAATCAAGAAGCTGA	0.383													0	0	0	0.014758	0	5	86										G	9934620	C	G	9934620	3	3	126	1	0	0	0	0	1	0	0	0	7936	816	29	1	117	1	JAGN1	3	9934620	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	150785	9934620	188087810	114	37412										
RPL15	6138	broad.mit.edu	37	chr3	23959373	23959373	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggtgcatacaagtacatccAggagctatggagaaagaagc	13	7	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:23959373A>G	uc003ccn.2	+	2	59	c.23A>G	c.(22-24)CAG>CGG	p.Q8R	NKIRAS1_uc003cck.2_Intron|NKIRAS1_uc003ccj.2_5'Flank|NKIRAS1_uc003ccl.2_5'Flank|NKIRAS1_uc003ccm.2_5'Flank|RPL15_uc011awi.1_Missense_Mutation_p.Q8R|RPL15_uc011awj.1_Missense_Mutation_p.Q8R|RPL15_uc003cco.2_Missense_Mutation_p.Q8R|RPL15_uc003ccp.2_Missense_Mutation_p.Q8R|RPL15_uc003ccq.2_Missense_Mutation_p.Q8R|RPL15_uc003ccr.2_Missense_Mutation_p.Q8R	NM_002948	NP_002939	P61313	RL15_HUMAN	ribosomal protein L15	8					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			ovary(1)	1						AAGTACATCCAGGAGCTATGG	0.493													0	0	0	0.007291	0	25	46										G	23959373	A	G	23959373	3	3	126	1	0	0	0	0	1	0	0	0	13562	188	7	5	25	5	RPL15	3	23959373	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	14024753	23959373	174063057	115	37413										
OXSM	54995	broad.mit.edu	37	chr3	25832554	25832554	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcctgaaaattacaagcactCgtcttctatgttcaagatta	5	9	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:25832554C>A	uc003cdn.2	+	2	150	c.43C>A	c.(43-45)CGT>AGT	p.R15S	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_5'UTR|OXSM_uc010hfh.2_Missense_Mutation_p.R15S	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	15					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						TACAAGCACTCGTCTTCTATG	0.388													1	0	2.89027e-11	0.014323	3.92963e-11	24	60										A	25832554	C	A	25832554	3	1	126	1	0	0	0	0	1	0	0	0	11335	884	31	3	45	3	OXSM	3	25832554	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1873181	25832554	172189876	116	37414										
SLC4A7	9497	broad.mit.edu	37	chr3	27446455	27446455	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaaagagactctattgcactCtgtttaaggaaaaaagaaat	7	5	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:27446455C>G	uc003cdv.2	-	14	1986	c.1915_splice	c.e14-1	p.S639_splice	SLC4A7_uc011awu.1_Splice_Site|SLC4A7_uc011awv.1_Splice_Site|SLC4A7_uc003cdu.3_Splice_Site_p.S520_splice|SLC4A7_uc011aww.1_Splice_Site_p.S648_splice|SLC4A7_uc011awx.1_Splice_Site_p.S635_splice|SLC4A7_uc011awy.1_Splice_Site_p.S631_splice|SLC4A7_uc011awz.1_Splice_Site|SLC4A7_uc011axa.1_Splice_Site_p.S520_splice|SLC4A7_uc011axb.1_Splice_Site_p.S635_splice|SLC4A7_uc010hfl.2_Splice_Site_p.S189_splice|SLC4A7_uc003cdw.2_Splice_Site_p.S515_splice	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate							apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CTATTGCACTCTGTTTAAGGA	0.353													0	0	0	0.008291	0	9	29										G	27446455	C	G	27446455	5	3	126	1	0	0	0	0	0	0	1	0	14658	927	32	1	1778	1	SLC4A7	3	27446455	Splice_Site	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1613901	27446455	170575975	117	37415										
ZNF620	253639	broad.mit.edu	37	chr3	40553923	40553923	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caccacgcctgttctggtctCccagctggagcaaggggaac	12	14	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:40553923C>G	uc003ckk.2	+	4	331	c.182C>G	c.(181-183)TCC>TGC	p.S61C	ZNF620_uc003ckl.2_Intron	NM_175888	NP_787084	Q6ZNG0	ZN620_HUMAN	zinc finger protein 620	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		GTTCTGGTCTCCCAGCTGGAG	0.572													0	0	0	0.004656	0	25	12										G	40553923	C	G	40553923	3	3	126	1	0	0	0	0	1	0	0	0	18041	855	30	1	192	1	ZNF620	3	40553923	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	13107468	40553923	157468507	118	37416										
ULK4	54986	broad.mit.edu	37	chr3	41942279	41942280	+	Missense_Mutation	DNP	TC	TC	AA													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgtgtagataagctctctcaTctgggattccaggtcctgct							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:41942279_41942280TC>AA	uc003ckv.3	-	13	1425_1426	c.1224_1225GA>TT	c.(1222-1227)CAGATG>CATTTG	p.408_409QM>HL	ULK4_uc003ckw.2_Missense_Mutation_p.408_409QM>HL|ULK4_uc003ckx.1_Missense_Mutation_p.408_409QM>HL	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	408_409							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGCTCTCTCATCTGGGATTCCA	0.411													0	0	0	0.004672	0	50	179										AA	41942280	TC	AA	41942279	3	1	126	1	0	0	0	0	1	0	0	0	16975	1435	50	5	2702	5	ULK4	3	41942279	Missense_Mutation	DNP	TC	TCGA-H4-A2HQ-01A-11D-A17V-08	1388356	41942279	156080151	119	37417										
ZNF445	353274	broad.mit.edu	37	chr3	44488486	44488486	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgacatttgaaaggtctctCtgtagagtggatcctctgat	10	8	3	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:44488486C>T	uc003cnf.2	-	8	3025	c.2677G>A	c.(2677-2679)GAG>AAG	p.E893K	ZNF445_uc011azv.1_Missense_Mutation_p.E881K|ZNF445_uc011azw.1_Missense_Mutation_p.E893K	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	893					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		AAAGGTCTCTCTGTAGAGTGG	0.453													0	0	0	0.007291	0	27	95										T	44488486	C	T	44488486	3	4	126	1	0	0	0	0	1	0	0	0	17915	922	32	1	422	1	ZNF445	3	44488486	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2546207	44488486	153533944	120	37418										
ZNF502	91392	broad.mit.edu	37	chr3	44763893	44763893	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attgagtgtggaaagttcttCagacatagttcagtcctttt	9	6	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:44763893C>T	uc011baa.1	+	4	1839	c.1584C>T	c.(1582-1584)TTC>TTT	p.F528F	ZNF502_uc003cns.2_Silent_p.F528F|ZNF502_uc011bab.1_Silent_p.F528F|ZNF502_uc003cnt.2_Silent_p.F528F	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	528	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		GAAAGTTCTTCAGACATAGTT	0.413													0	0	0	0.004482	0	9	41										T	44763893	C	T	44763893	2	4	126	1	0	0	0	0	0	0	0	1	17947	825	29	1		1	ZNF502	3	44763893	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	275407	44763893	153258537	121	37419										
DHX30	22907	broad.mit.edu	37	chr3	47887268	47887268	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctctttgcgtgagctgggtGagacccagcgccgaccatgc	13	14	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:47887268G>T	uc003cru.2	+	10	1444	c.1018G>T	c.(1018-1020)GAG>TAG	p.E340*	DHX30_uc003crt.2_Nonsense_Mutation_p.E301*|DHX30_uc010hjr.1_Nonsense_Mutation_p.E368*	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	340						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TGAGCTGGGTGAGACCCAGCG	0.597													1	0	6.05902e-23	0.017118	8.50317e-23	35	26										T	47887268	G	T	47887268	4	4	126	1	0	0	0	0	0	1	0	0	4504	1291	45	3	1059	3	DHX30	3	47887268	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3123375	47887268	150135162	122	37420										
COL7A1	1294	broad.mit.edu	37	chr3	48612135	48612135	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcctttgggaccttggtcaCcattgctgcccggctccccc	9	18	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:48612135C>A	uc003ctz.2	-	77	6369	c.6368G>T	c.(6367-6369)GGT>GTT	p.G2123V		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2123	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACCTTGGTCACCATTGCTGCC	0.597													1	0	2.17888e-05	0.006214	2.82776e-05	9	47										A	48612135	C	A	48612135	3	1	126	1	0	0	0	0	1	0	0	0	3704	507	18	4	2634	4	COL7A1	3	48612135	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	724867	48612135	149410295	123	37421										
CELSR3	1951	broad.mit.edu	37	chr3	48698069	48698069	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatgtggatgactgagtgacCcaagggagcattttccaaga	12	7	0	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:48698069C>A	uc003cul.2	-	1	2280	c.1999G>T	c.(1999-2001)GGT>TGT	p.G667C	CELSR3_uc003cuf.1_Missense_Mutation_p.G737C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	667	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACTGAGTGACCCAAGGGAGCA	0.517													1	0	5.3912e-06	0.006122	7.052e-06	17	42										A	48698069	C	A	48698069	3	1	126	1	0	0	0	0	1	0	0	0	3223	623	22	4	8079	4	CELSR3	3	48698069	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	85934	48698069	149324361	124	37422										
USP4	7375	broad.mit.edu	37	chr3	49363263	49363263	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttgcagtgcttgacaaacaGgccatgctccacaacctatg	8	12	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:49363263G>A	uc003cwq.2	-	4	455	c.376C>T	c.(376-378)CTG>TTG	p.L126L	USP4_uc003cwr.2_Silent_p.L126L	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	126					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		TTGACAAACAGGCCATGCTCC	0.498													0	0	0	0.007835	0	35	119										A	49363263	G	A	49363263	2	1	126	1	0	0	0	0	0	0	0	1	17068	991	35	2		2	USP4	3	49363263	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	665194	49363263	148659167	125	37423										
RHOA	387	broad.mit.edu	37	chr3	49400019	49400019	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgatgggcacgttgggacaGaaatgcttgacttctggggt	15	6	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:49400019G>C	uc003cwu.2	-	4	594	c.318C>G	c.(316-318)TTC>TTG	p.F106L	RHOA_uc010hku.2_Missense_Mutation_p.F25L	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	106					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	CGTTGGGACAGAAATGCTTGA	0.443													0	0	0	0.01441	0	46	46										C	49400019	G	C	49400019	3	2	126	1	0	0	0	0	1	0	0	0	13331	933	33	1	271	1	RHOA	3	49400019	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	36756	49400019	148622411	126	37424										
DOCK3	1795	broad.mit.edu	37	chr3	51112865	51112865	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attagtgtctcagatctctaTaagatggtaagaaatctaac	7	6	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:51112865T>C	uc011bds.1	+	7	566	c.543T>C	c.(541-543)TAT>TAC	p.Y181Y		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	181						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGATCTCTATAAGATGGTAA	0.393													0	0	0	0.00308	0	8	0										C	51112865	T	C	51112865	2	2	126	1	0	0	0	0	0	0	0	1	4688	1413	49	5		5	DOCK3	3	51112865	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	1712846	51112865	146909565	127	37425										
COL8A1	1295	broad.mit.edu	37	chr3	99513764	99513764	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggggagcaaggactgccagGgctaccaggacccccaggcc	15	14	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:99513764G>A	uc003dtg.1	+	5	1264	c.1019G>A	c.(1018-1020)GGG>GAG	p.G340E	COL8A1_uc003dth.1_Missense_Mutation_p.G340E|COL8A1_uc003dti.1_Missense_Mutation_p.G341E	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	340	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						GGACTGCCAGGGCTACCAGGA	0.627													0	0	0	0.009096	0	4	62										A	99513764	G	A	99513764	3	1	126	1	0	0	0	0	1	0	0	0	3705	1232	43	2	1025	2	COL8A1	3	99513764	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	48400899	99513764	98508666	128	37426										
GPR128	84873	broad.mit.edu	37	chr3	100362453	100362453	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagatgcacagactgagcttCaggtcttgcttaatatgacg	10	9	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:100362453C>G	uc003duc.2	+	8	1190	c.922C>G	c.(922-924)CAG>GAG	p.Q308E	GPR128_uc011bhc.1_Intron	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	308	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GACTGAGCTTCAGGTCTTGCT	0.363													0	0	0	0.013114	0	45	28										G	100362453	C	G	100362453	3	3	126	1	0	0	0	0	1	0	0	0	6641	827	29	1	952	1	GPR128	3	100362453	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	848689	100362453	97659977	129	37427										
SIDT1	54847	broad.mit.edu	37	chr3	113327035	113327035	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgacatcctccatcggagaGccctggaagccaaggacatc	11	14	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:113327035G>T	uc003eak.2	+	16	2224	c.1573G>T	c.(1573-1575)GCC>TCC	p.A525S	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.A525S|SIDT1_uc011big.1_Missense_Mutation_p.A278S|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	525	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						CCATCGGAGAGCCCTGGAAGC	0.542													1	0	1.64293e-13	0.01892	2.25223e-13	26	125										T	113327035	G	T	113327035	3	4	126	1	0	0	0	0	1	0	0	0	14302	971	34	4	1635	4	SIDT1	3	113327035	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	12964582	113327035	84695395	130	37428										
NR1I2	8856	broad.mit.edu	37	chr3	119535943	119535943	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcctgaagatcatggctatgCtcaccgagctccgcagcatc	9	14	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:119535943C>A	uc003edj.2	+	9	3028	c.1189C>A	c.(1189-1191)CTC>ATC	p.L397I	NR1I2_uc003edi.2_Missense_Mutation_p.L360I|NR1I2_uc003edk.2_Missense_Mutation_p.L436I|NR1I2_uc003edl.2_Missense_Mutation_p.L285I	NM_003889	NP_003880	O75469	NR1I2_HUMAN	nuclear receptor subfamily 1, group I, member 2	397	Ligand-binding.				drug export|exogenous drug catabolic process|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid metabolic process|xenobiotic metabolic process|xenobiotic transport	nucleoplasm	drug binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(114;0.175)	Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Rifampin(DB01045)|Vitamin E(DB00163)	CATGGCTATGCTCACCGAGCT	0.592													1	0	3.05275e-18	0.013114	4.25534e-18	44	91										A	119535943	C	A	119535943	3	1	126	1	0	0	0	0	1	0	0	0	10620	797	28	4	1340	4	NR1I2	3	119535943	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6208908	119535943	78486487	131	37429										
POLQ	10721	broad.mit.edu	37	chr3	121209029	121209029	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaatgtgtgttcctttacttCggactcactatgagtcaatg	8	8	2	1	rs149007312	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:121209029C>T	uc003eee.3	-	16	2878	c.2749G>A	c.(2749-2751)GAA>AAA	p.E917K	POLQ_uc003eed.2_Missense_Mutation_p.E89K	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	917					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TCCTTTACTTCGGACTCACTA	0.338								DNA_polymerases_(catalytic_subunits)					0	0	0	0.007835	0	42	46										T	121209029	C	T	121209029	3	4	126	1	0	0	0	0	1	0	0	0	12208	893	31	1	5083	1	POLQ	3	121209029	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1673086	121209029	76813401	132	37430										
ZNF148	7707	broad.mit.edu	37	chr3	124951899	124951899	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctgcaacactgaaggatatCtcatgctgtccattagcttt	7	10	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:124951899C>G	uc003ehx.3	-	9	2157	c.1671G>C	c.(1669-1671)GAG>GAC	p.E557D	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Missense_Mutation_p.E557D|ZNF148_uc010hsa.2_Missense_Mutation_p.E557D|ZNF148_uc003eia.3_Missense_Mutation_p.E557D|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	557					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						TGAAGGATATCTCATGCTGTC	0.398													0	0	0	0.004482	0	8	44										G	124951899	C	G	124951899	3	3	126	1	0	0	0	0	1	0	0	0	17731	912	32	1	717	1	ZNF148	3	124951899	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3742870	124951899	73070531	133	37431										
C3orf22	152065	broad.mit.edu	37	chr3	126272147	126272147	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggtgtcagcctcccgcacctGtacggaaacttcttggcaaa	10	13	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:126272147G>A	uc003ejb.2	-	2	416	c.87C>T	c.(85-87)TAC>TAT	p.Y29Y		NM_152533	NP_689746	Q8N5N4	CC022_HUMAN	hypothetical protein LOC152065	29											0				GBM - Glioblastoma multiforme(114;0.147)		TCCCGCACCTGTACGGAAACT	0.567													0	0	0	0.003163	0	15	638										A	126272147	G	A	126272147	2	1	126	1	0	0	0	0	0	0	0	1	2215	1372	48	2		2	C3orf22	3	126272147	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1320248	126272147	71750283	134	37432										
NEK11	79858	broad.mit.edu	37	chr3	130828671	130828671	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagatctggacgataaaattCaggaatataaacaagctgga	10	5	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:130828671C>T	uc003eny.2	+	5	687	c.361C>T	c.(361-363)CAG>TAG	p.Q121*	NEK11_uc003enx.2_Nonsense_Mutation_p.Q121*|NEK11_uc003eoa.2_Nonsense_Mutation_p.Q121*|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_5'UTR|NEK11_uc011bll.1_Nonsense_Mutation_p.Q121*|NEK11_uc003enw.1_Nonsense_Mutation_p.Q121*|NEK11_uc011blm.1_Nonsense_Mutation_p.Q121*|NEK11_uc010hto.1_5'UTR	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	121	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						CGATAAAATTCAGGAATATAA	0.338													0	0	0	0.013726	0	31	24										T	130828671	C	T	130828671	4	4	126	1	0	0	0	0	0	1	0	0	10323	827	29	1	371	1	NEK11	3	130828671	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4556524	130828671	67193759	135	37433										
PLCH1	23007	broad.mit.edu	37	chr3	155203300	155203300	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catcttgatctcttgtggccTcggacacagaatcctttatc	7	12	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:155203300T>A	uc011bok.1	-	22	3120	c.2843A>T	c.(2842-2844)GAG>GTG	p.E948V	PLCH1_uc011boj.1_Missense_Mutation_p.E948V|PLCH1_uc011bol.1_Missense_Mutation_p.E910V	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	948					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCTTGTGGCCTCGGACACAGA	0.522													0	0	0	0.013114	0	43	132										A	155203300	T	A	155203300	3	1	126	1	0	0	0	0	1	0	0	0	12037	1551	54	5	2261	5	PLCH1	3	155203300	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	24374629	155203300	42819130	136	37434										
SI	6476	broad.mit.edu	37	chr3	164750379	164750379	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttattttccgccactctaacTtctgtaacactgtctgtcaa	4	12	4	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:164750379T>A	uc003fei.2	-	24	2729	c.2667A>T	c.(2665-2667)GAA>GAT	p.E889D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	889	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CCACTCTAACTTCTGTAACAC	0.348										HNSCC(35;0.089)			0	0	0	0.010729	0	10	8										A	164750379	T	A	164750379	3	1	126	1	0	0	0	0	1	0	0	0	14297	1606	56	5	2916	5	SI	3	164750379	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	9547079	164750379	33272051	137	37435										
SERPINI2	5276	broad.mit.edu	37	chr3	167183097	167183097	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttcttctatatccataccttCtgcaggaagtatgataatta	5	8	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:167183097C>G	uc003fer.1	-	4	821	c.763G>C	c.(763-765)GAA>CAA	p.E255Q	SERPINI2_uc003fes.1_Missense_Mutation_p.E265Q|SERPINI2_uc003fet.1_Missense_Mutation_p.E255Q	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	255					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TCCATACCTTCTGCAGGAAGT	0.358													0	0	0	0.010729	0	11	102										G	167183097	C	G	167183097	3	3	126	1	0	0	0	0	1	0	0	0	14119	922	32	1	474	1	SERPINI2	3	167183097	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2432718	167183097	30839333	138	37436										
DCUN1D1	54165	broad.mit.edu	37	chr3	182681826	182681826	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atctattccaattttattctCatcttgagggtctttaaaaa	4	7	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:182681826C>A	uc003fld.1	-	3	281	c.232G>T	c.(232-234)GAG>TAG	p.E78*	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	78	DCUN1.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			ATTTTATTCTCATCTTGAGGG	0.353													1	0	2.7689e-08	0.001984	3.69782e-08	7	48										A	182681826	C	A	182681826	4	1	126	1	0	0	0	0	0	1	0	0	4313	835	29	3	567	3	DCUN1D1	3	182681826	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	15498729	182681826	15340604	139	37437										
C3orf70	285382	broad.mit.edu	37	chr3	184801154	184801154	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acatttaacctgatagttgtCaataaaaaggtctgaaatca	6	6	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:184801154C>T	uc003fpd.2	-	2	585	c.394G>A	c.(394-396)GAC>AAC	p.D132N		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	132											0						TGATAGTTGTCAATAAAAAGG	0.468													0	0	0	0.010504	0	20	113										T	184801154	C	T	184801154	3	4	126	1	0	0	0	0	1	0	0	0	2242	826	29	1	362	1	C3orf70	3	184801154	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2119328	184801154	13221276	140	37438										
ETV5	2119	broad.mit.edu	37	chr3	185798944	185798944	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcccgtttgatcttggttgGaggtggggcatgaagcacca	14	9	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:185798944G>C	uc003fpz.2	-	6	500	c.253C>G	c.(253-255)CCA>GCA	p.P85A	ETV5_uc003fpy.2_Missense_Mutation_p.P127A	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	85					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			ATCTTGGTTGGAGGTGGGGCA	0.512			T	TMPRSS2|SCL45A3	Prostate 								0	0	0	0.01441	0	85	104										C	185798944	G	C	185798944	3	2	126	1	0	0	0	0	1	0	0	0	5282	1174	41	1	1311	1	ETV5	3	185798944	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	997790	185798944	12223486	141	37439										
LPP	4026	broad.mit.edu	37	chr3	188327375	188327375	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caggacttcagccggagcctGggtatgggtatgcccccaac	13	13	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr3:188327375G>A	uc003frs.1	+	6	1102	c.856G>A	c.(856-858)GGG>AGG	p.G286R	LPP_uc011bsg.1_Intron|LPP_uc011bsi.1_Missense_Mutation_p.G286R|LPP_uc003frt.2_Missense_Mutation_p.G286R|LPP_uc011bsj.1_Missense_Mutation_p.G123R	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	286	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		GCCGGAGCCTGGGTATGGGTA	0.567			T	HMGA2|MLL|C12orf9	lipoma|leukemia								0	0	0	0.010729	0	11	96										A	188327375	G	A	188327375	3	1	126	1	0	0	0	0	1	0	0	0	8923	1348	47	2	870	2	LPP	3	188327375	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2528431	188327375	9695055	142	37440										
PIGG	54872	broad.mit.edu	37	chr4	494383	494383	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acctacagttactatgcctcGaatcaaggtaagtttgcctt	7	10	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:494383G>A	uc003gak.3	+	2	489	c.353G>A	c.(352-354)CGA>CAA	p.R118Q	PIGG_uc003gaj.3_Missense_Mutation_p.R118Q|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.R118Q|PIGG_uc003gal.3_Missense_Mutation_p.R29Q|ZNF721_uc003gag.2_5'Flank|ZNF721_uc010ibe.2_5'Flank|ZNF721_uc003gah.1_5'Flank|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_5'UTR|PIGG_uc003gam.2_Missense_Mutation_p.R29Q|PIGG_uc003gan.2_Missense_Mutation_p.R29Q	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	118	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						ACTATGCCTCGAATCAAGGTA	0.408													0	0	0	0.01892	0	23	18										A	494383	G	A	494383	3	1	126	1	0	0	0	0	1	0	0	0	11888	1058	37	1	359	1	PIGG	4	494383	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		494383	190659893	143	37441										
PDE6B	5158	broad.mit.edu	37	chr4	628477	628477	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttgcggcagtgccctcacttCagctcatttgctgacgagct	10	13	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:628477C>T	uc003gap.2	+	2	533	c.480C>T	c.(478-480)TTC>TTT	p.F160F	PDE6B_uc003gao.3_Silent_p.F160F	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	160	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GCCCTCACTTCAGCTCATTTG	0.567													0	0	0	0.005524	0	35	76										T	628477	C	T	628477	2	4	126	1	0	0	0	0	0	0	0	1	11646	825	29	1		1	PDE6B	4	628477	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	134094	628477	190525799	144	37442										
FGFR3	2261	broad.mit.edu	37	chr4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atctgcccccacagagcgctCcccgcaccggcccatcctgc	8	22	1	1	rs121913483		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.013726	0	22	15										G	1803568	C	G	1803568	3	3	126	1	0	0	0	0	1	0	0	0	5867	855	30	1	768	1	FGFR3	4	1803568	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1175091	1803568	189350708	145	37443										
OTOP1	133060	broad.mit.edu	37	chr4	4199019	4199019	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagctgctctcctcctgcttCtcctcctccttgtcatggct	6	18	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:4199019C>G	uc003ghp.1	-	5	1572	c.1542G>C	c.(1540-1542)GAG>GAC	p.E514D		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	514					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCTCCTGCTTCTCCTCCTCCT	0.577													0	0	0	0.014323	0	20	70										G	4199019	C	G	4199019	3	3	126	1	0	0	0	0	1	0	0	0	11305	912	32	1	304	1	OTOP1	4	4199019	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2395451	4199019	186955257	146	37444										
ZBTB49	166793	broad.mit.edu	37	chr4	4314802	4314802	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gactcacttacgacggcattCtggtgaaaaaccatacatct	7	11	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:4314802C>G	uc003ghu.2	+	5	1512	c.1337C>G	c.(1336-1338)TCT>TGT	p.S446C	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_Intron|ZBTB49_uc010icz.2_Intron	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CGACGGCATTCTGGTGAAAAA	0.413													0	0	0	0.01892	0	19	47										G	4314802	C	G	4314802	3	3	126	1	0	0	0	0	1	0	0	0	17547	913	32	1	1351	1	ZBTB49	4	4314802	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	115783	4314802	186839474	147	37445										
EVC2	132884	broad.mit.edu	37	chr4	5586480	5586480	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acagagtctcggtcacccggGacgccttctggaactgcaga	12	13	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:5586480G>C	uc003gij.2	-	17	2981	c.2927C>G	c.(2926-2928)TCC>TGC	p.S976C	EVC2_uc011bwb.1_Missense_Mutation_p.S416C|EVC2_uc003gik.2_Missense_Mutation_p.S896C	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	976						integral to membrane				large_intestine(3)|ovary(2)	5						GGTCACCCGGGACGCCTTCTG	0.607													0	0	0	0.006122	0	16	35										C	5586480	G	C	5586480	3	2	126	1	0	0	0	0	1	0	0	0	5286	1174	41	1	1023	1	EVC2	4	5586480	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1271678	5586480	185567796	148	37446										
TXK	7294	broad.mit.edu	37	chr4	48106974	48106974	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatgtttctatggtaccaccTgtaaaagcaataaaaatgat	6	6	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:48106974T>C	uc003gxx.3	-	6	533	c.447_splice	c.e6-1	p.E149_splice	TXK_uc003gxy.1_Splice_Site_p.E149_splice	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase							cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TGGTACCACCTGTAAAAGCaa	0.274													0	0	0	0.006214	0	10	19										C	48106974	T	C	48106974	5	2	126	1	0	0	0	0	0	0	1	0	16783	1594	55	5	1178	5	TXK	4	48106974	Splice_Site	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	42520494	48106974	143047302	149	37447										
LPHN3	23284	broad.mit.edu	37	chr4	62849142	62849142	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccctgttacatttcttcttCttggctgccttcacctggat	7	13	4	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:62849142C>A	uc010ihh.2	+	16	3026	c.2853C>A	c.(2851-2853)TTC>TTA	p.F951L	LPHN3_uc003hcq.3_Missense_Mutation_p.F951L|LPHN3_uc003hct.2_Missense_Mutation_p.F344L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	938	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATTTCTTCTTCTTGGCTGCCT	0.433													1	0	0.00024832	0.009096	0.000317298	4	16										A	62849142	C	A	62849142	3	1	126	1	0	0	0	0	1	0	0	0	8917	912	32	3	2915	3	LPHN3	4	62849142	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	14742168	62849142	128305134	150	37448										
COPS4	51138	broad.mit.edu	37	chr4	83984325	83984325	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agagaaaatgtatctagataGgatcatcagaggaaatcaac	9	5	4	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:83984325G>A	uc003hoa.2	+	7	951	c.812G>A	c.(811-813)AGG>AAG	p.R271K	COPS4_uc003hob.2_Missense_Mutation_p.R271K|COPS4_uc010ijw.2_Missense_Mutation_p.R271K|COPS4_uc010ijx.2_Missense_Mutation_p.R271K	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	271	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				TATCTAGATAGGATCATCAGA	0.428													0	0	0	0.007413	0	20	45										A	83984325	G	A	83984325	3	1	126	1	0	0	0	0	1	0	0	0	3735	1000	35	2	838	2	COPS4	4	83984325	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	21135183	83984325	107169951	151	37449										
WDFY3	23001	broad.mit.edu	37	chr4	85634326	85634326	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acctacccctgctccacactCgtgtttggtcgttgcccaga	8	16	0	1	rs150169644	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:85634326C>A	uc003hpd.2	-	51	8436	c.8028G>T	c.(8026-8028)ACG>ACT	p.T2676T	WDFY3_uc003hpe.1_Silent_p.T287T	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2676						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCTCCACACTCGTGTTTGGTC	0.383													1	0	1.85257e-25	0.01441	2.60873e-25	59	158										A	85634326	C	A	85634326	2	1	126	1	0	0	0	0	0	0	0	1	17267	871	31	3		3	WDFY3	4	85634326	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1650001	85634326	105519950	152	37450										
HSD17B13	345275	broad.mit.edu	37	chr4	88238286	88238286	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acctcaaatgtcttggtaatCtcttcatccttggtgctgag	8	10	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:88238286C>A	uc003hqo.2	-	3	471	c.408G>T	c.(406-408)GAG>GAT	p.E136D	HSD17B13_uc010ikk.2_Missense_Mutation_p.E100D	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	136						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TCTTGGTAATCTCTTCATCCT	0.403													1	0	0.00400662	0.004007	0.00503412	15	54										A	88238286	C	A	88238286	3	1	126	1	0	0	0	0	1	0	0	0	7382	912	32	3	514	3	HSD17B13	4	88238286	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2603960	88238286	102915990	153	37451										
PDHA2	5161	broad.mit.edu	37	chr4	96761707	96761707	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tccgatccattctcgcagagCtgacgggaagaagaggaggt	14	9	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:96761707C>T	uc003htr.3	+	1	469	c.406C>T	c.(406-408)CTG>TTG	p.L136L		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	136					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TCTCGCAGAGCTGACGGGAAG	0.517													0	0	0	0.010504	0	20	56										T	96761707	C	T	96761707	2	4	126	1	0	0	0	0	0	0	0	1	11665	796	28	2		2	PDHA2	4	96761707	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8523421	96761707	94392569	154	37452										
MANBA	4126	broad.mit.edu	37	chr4	103571706	103571706	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caacttacctgagtaaggtaGatggtatctttaaatgtgcg	10	6	1	2	rs141009346		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:103571706G>C	uc003hwg.2	-	13	1957	c.1857C>G	c.(1855-1857)ATC>ATG	p.I619M	MANBA_uc011ces.1_Missense_Mutation_p.I562M	NM_005908	NP_005899	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal precursor	619					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GAGTAAGGTAGATGGTATCTT	0.363													0	0	0	0.00308	0	7	32										C	103571706	G	C	103571706	3	2	126	1	0	0	0	0	1	0	0	0	9219	932	33	1	802	1	MANBA	4	103571706	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6809999	103571706	87582570	155	37453										
KIAA1109	84162	broad.mit.edu	37	chr4	123117944	123117944	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atttgctgtttaccaaaaatAgggtaattattataataata	5	3	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:123117944A>C	uc003ieh.2	+	10	1252	c.1207A>C	c.(1207-1209)AGG>CGG	p.R403R	KIAA1109_uc003iei.1_Silent_p.R157R|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	403					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TACCAAAAATAGGGtaattat	0.284													0	0	0	0.010729	0	12	27										C	123117944	A	C	123117944	2	2	126	1	0	0	0	0	0	0	0	1	8208	411	15	5		5	KIAA1109	4	123117944	Silent	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	19546238	123117944	68036332	156	37454										
PDGFC	56034	broad.mit.edu	37	chr4	157684305	157684305	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggtgctccagggccacgtcGgtgagtgatttgtgcaatcc	14	10	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:157684305G>C	uc003iph.1	-	6	1466	c.975C>G	c.(973-975)ACC>ACG	p.T325T	PDGFC_uc003ipi.1_Silent_p.T162T|PDGFC_uc011cis.1_Silent_p.T162T|PDGFC_uc011cir.1_Silent_p.T169T	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	325					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		GGGCCACGTCGGTGAGTGATT	0.527													0	0	0	0.010729	0	10	27										C	157684305	G	C	157684305	2	2	126	1	0	0	0	0	0	0	0	1	11659	1103	39	4		4	PDGFC	4	157684305	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	34566361	157684305	33469971	157	37455										
TLL1	7092	broad.mit.edu	37	chr4	167020652	167020652	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggtcttgattcaacagctgtGgggcttggtcgattctgtgg	15	7	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:167020652G>T	uc003irh.1	+	20	3527	c.2880G>T	c.(2878-2880)GTG>GTT	p.V960V	TLL1_uc011cjn.1_Silent_p.V983V|TLL1_uc011cjo.1_Silent_p.V784V	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	960	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CAACAGCTGTGGGGCTTGGTC	0.433													1	0	4.36969e-10	0.016723	5.90229e-10	13	37										T	167020652	G	T	167020652	2	4	126	1	0	0	0	0	0	0	0	1	15942	1335	47	4		4	TLL1	4	167020652	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	9336347	167020652	24133624	158	37456										
CBR4	84869	broad.mit.edu	37	chr4	169931103	169931103	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccagtttggtacctaccgccGaggtcaccggcggcggcttt	13	14	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:169931103G>A	uc003iry.2	-	1	320	c.138C>T	c.(136-138)CTC>CTT	p.L46L	CBR4_uc011cjy.1_RNA|CBR4_uc003irz.1_Silent_p.L46L	NM_032783	NP_116172	Q8N4T8	CBR4_HUMAN	carbonic reductase 4	46					fatty acid biosynthetic process|protein homotetramerization	mitochondrial matrix	NADPH binding|NADPH dehydrogenase (quinone) activity|protein binding|quinone binding				0		Prostate(90;0.00263)|Renal(120;0.0183)|Melanoma(52;0.123)		GBM - Glioblastoma multiforme(119;0.0321)		ACCTACCGCCGAGGTCACCGG	0.587											OREG0016397	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	10	26										A	169931103	G	A	169931103	2	1	126	1	0	0	0	0	0	0	0	1	2710	1045	37	1		1	CBR4	4	169931103	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2910451	169931103	21223173	159	37457										
VEGFC	7424	broad.mit.edu	37	chr4	177608517	177608517	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccccacattggctggggaaGagtttgtttttacagacaca	11	9	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr4:177608517G>C	uc003ius.1	-	6	1399	c.969C>G	c.(967-969)CTC>CTG	p.L323L		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	323	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GGCTGGGGAAGAGTTTGTTTT	0.502													0	0	0	0.010818	0	28	75										C	177608517	G	C	177608517	2	2	126	1	0	0	0	0	0	0	0	1	17149	929	33	1		1	VEGFC	4	177608517	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7677414	177608517	13545759	160	37458										
SLC12A7	10723	broad.mit.edu	37	chr5	1087072	1087072	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcccctgcaaacgtcgtgccCaggtagaagcagaggccgac	13	14	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:1087072C>T	uc003jbu.2	-	6	687	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	207	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ACGTCGTGCCCAGGTAGAAGC	0.587													0	0	0	0.007413	0	19	82										T	1087072	C	T	1087072	2	4	126	1	0	0	0	0	0	0	0	1	14388	581	21	2		2	SLC12A7	5	1087072	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		1087072	179828188	161	37459										
IRX2	153572	broad.mit.edu	37	chr5	2748596	2748596	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccgcggccgcagagttgtacCgcaggagaccctggccctgc	14	16	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:2748596C>A	uc003jda.2	-	3	1468	c.1226G>T	c.(1225-1227)CGG>CTG	p.R409L	IRX2_uc003jdb.2_Missense_Mutation_p.R409L	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	409						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		AGAGTTGTACCGCAGGAGACC	0.716													1	0	8.16721e-17	0.010818	1.13274e-16	31	67										A	2748596	C	A	2748596	3	1	126	1	0	0	0	0	1	0	0	0	7844	652	23	4	197	4	IRX2	5	2748596	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1661524	2748596	178166664	162	37460										
ADAMTS16	170690	broad.mit.edu	37	chr5	5190099	5190099	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacagccaggactggtgataAgtcaccacgcagaccacacc	9	15	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:5190099A>T	uc003jdl.2	+	7	1201	c.1063A>T	c.(1063-1065)AGT>TGT	p.S355C	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S355C|ADAMTS16_uc003jdj.1_Missense_Mutation_p.S355C	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	355	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ACTGGTGATAAGTCACCACGC	0.473													0	0	0	0.013537	0	11	110										T	5190099	A	T	5190099	3	4	126	1	0	0	0	0	1	0	0	0	261	72	3	5	1089	5	ADAMTS16	5	5190099	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	2441503	5190099	175725161	163	37461										
ADCY2	108	broad.mit.edu	37	chr5	7695884	7695884	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcatcttatacgctgacatcGttggctttacccggctggca	10	12	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:7695884G>A	uc003jdz.1	+	6	956	c.889G>A	c.(889-891)GTT>ATT	p.V297I	ADCY2_uc011cmo.1_Missense_Mutation_p.V117I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	297	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGCTGACATCGTTGGCTTTAC	0.408													0	0	0	0.015359	0	34	57										A	7695884	G	A	7695884	3	1	126	1	0	0	0	0	1	0	0	0	294	1145	40	2	911	2	ADCY2	5	7695884	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2505785	7695884	173219376	164	37462										
FASTKD3	79072	broad.mit.edu	37	chr5	7867275	7867275	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagaggaaatgcttgactttGatcaagaaccaccagggcag	11	9	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:7867275G>C	uc003jeb.2	-	2	1059	c.922C>G	c.(922-924)CAA>GAA	p.Q308E	FASTKD3_uc011cmp.1_Missense_Mutation_p.Q10E|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	308					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						GCTTGACTTTGATCAAGAACC	0.393													0	0	0	0.005443	0	25	204										C	7867275	G	C	7867275	3	2	126	1	0	0	0	0	1	0	0	0	5687	1299	45	1	1090	1	FASTKD3	5	7867275	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	171391	7867275	173047985	165	37463										
CTNND2	1501	broad.mit.edu	37	chr5	11098851	11098851	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acagtctggaagaggtcctaCtccatcccactggcggaaga	11	12	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:11098851C>A	uc003jfa.1	-	15	2618	c.2473G>T	c.(2473-2475)GTA>TTA	p.V825L	CTNND2_uc010itt.2_Missense_Mutation_p.V734L|CTNND2_uc011cmy.1_Missense_Mutation_p.V488L|CTNND2_uc011cmz.1_Missense_Mutation_p.V392L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.V392L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	825					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AGAGGTCCTACTCCATCCCAC	0.468													1	0	3.86212e-05	0.008291	4.98105e-05	9	83										A	11098851	C	A	11098851	3	1	126	1	0	0	0	0	1	0	0	0	4020	565	20	4	1236	4	CTNND2	5	11098851	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3231576	11098851	169816409	166	37464										
TRIO	7204	broad.mit.edu	37	chr5	14381300	14381300	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacacacacctccacgggctCcagtatacagcacacccagg	7	18	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:14381300C>G	uc003jff.2	+	21	3515	c.3509C>G	c.(3508-3510)TCC>TGC	p.S1170C	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.S1121C|TRIO_uc003jfh.1_Missense_Mutation_p.S819C	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1170	Spectrin 4.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					TCCACGGGCTCCAGTATACAG	0.512													0	0	0	0.01441	0	70	130										G	14381300	C	G	14381300	3	3	126	1	0	0	0	0	1	0	0	0	16549	855	30	1	3591	1	TRIO	5	14381300	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3282449	14381300	166533960	167	37465										
TRIO	7204	broad.mit.edu	37	chr5	14387928	14387928	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgctcatgaacttaatgaaGagaagcggaaatctgcccgc	10	10	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:14387928G>C	uc003jff.2	+	23	3859	c.3853G>C	c.(3853-3855)GAG>CAG	p.E1285Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.E1236Q|TRIO_uc003jfh.1_Missense_Mutation_p.E934Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1285					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					ACTTAATGAAGAGAAGCGGAA	0.443													0	0	0	0.016723	0	13	106										C	14387928	G	C	14387928	3	2	126	1	0	0	0	0	1	0	0	0	16549	943	33	1	3943	1	TRIO	5	14387928	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6628	14387928	166527332	168	37466										
MARCH11	441061	broad.mit.edu	37	chr5	16177939	16177939	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccattttagcaggcacagctGatgtgtataccgaactgacc	9	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:16177939G>T	uc003jfo.2	-	2	802	c.589C>A	c.(589-591)CAG>AAG	p.Q197K	uc003jfp.2_5'Flank	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	197	RING-CH-type.					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AGGCACAGCTGATGTGTATAC	0.423													1	0	2.32078e-09	0.003163	3.11444e-09	14	128										T	16177939	G	T	16177939	3	4	126	1	0	0	0	0	1	0	0	0	9300	1299	45	3	631	3	MARCH11	5	16177939	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1790011	16177939	164737321	169	37467										
CDH12	1010	broad.mit.edu	37	chr5	21802336	21802336	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagcgccaatgatggtccctAccggagtgtcttcataaacc	9	13	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:21802336A>T	uc010iuc.2	-	7	1654	c.1196T>A	c.(1195-1197)GTA>GAA	p.V399E	CDH12_uc011cno.1_Missense_Mutation_p.V359E|CDH12_uc003jgk.2_Missense_Mutation_p.V399E	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	399	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GATGGTCCCTACCGGAGTGTC	0.478										HNSCC(59;0.17)			0	0	0	0.008871	0	19	17										T	21802336	A	T	21802336	3	4	126	1	0	0	0	0	1	0	0	0	3098	391	14	5	1212	5	CDH12	5	21802336	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	5624397	21802336	159112924	170	37468										
PRDM9	56979	broad.mit.edu	37	chr5	23526574	23526574	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggtcaagagatcaaagaaagGtccaaactcttgaataaaag	9	6	3	3	rs112001060		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:23526574G>A	uc003jgo.2	+	11	1559	c.1377G>A	c.(1375-1377)AGG>AGA	p.R459R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	459					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCAAAGAAAGGTCCAAACTCT	0.468										HNSCC(3;0.000094)			0	0	0	0.005443	0	29	17										A	23526574	G	A	23526574	2	1	126	1	0	0	0	0	0	0	0	1	12463	1252	44	2		2	PRDM9	5	23526574	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1724238	23526574	157388686	171	37469										
MTMR12	54545	broad.mit.edu	37	chr5	32239280	32239280	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaggtcggatgcattctcctCtaggagaggccccagcagca	13	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:32239280C>G	uc003jhq.2	-	13	1342	c.1172_splice	c.e13-1	p.E391_splice	MTMR12_uc010iuk.2_Splice_Site_p.E391_splice|MTMR12_uc010iul.2_Splice_Site_p.E391_splice	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12							cytoplasm	phosphatase activity			ovary(1)	1						GCATTCTCCTCTAGGAGAGGC	0.483													0	0	0	0.003163	0	14	90										G	32239280	C	G	32239280	5	3	126	1	0	0	0	0	0	0	1	0	9941	927	32	1	1088	1	MTMR12	5	32239280	Splice_Site	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8712706	32239280	148675980	172	37470										
OSMR	9180	broad.mit.edu	37	chr5	38917668	38917668	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctccctcagaggcccctgatGtctggagaattgtgagcttg	12	11	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:38917668G>A	uc003jln.1	+	10	1673	c.1306G>A	c.(1306-1308)GTC>ATC	p.V436I	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	436	Fibronectin type-III 2.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GGCCCCTGATGTCTGGAGAAT	0.408													0	0	0	0.012319	0	22	174										A	38917668	G	A	38917668	3	1	126	1	0	0	0	0	1	0	0	0	11292	1377	48	2	1378	2	OSMR	5	38917668	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6678388	38917668	141997592	173	37471										
PTGER4	5734	broad.mit.edu	37	chr5	40692210	40692210	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagaccctcctgccagacctCtcactgccagacctcagtga	7	18	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:40692210C>G	uc003jlz.2	+	3	1789	c.1197C>G	c.(1195-1197)CTC>CTG	p.L399L		NM_000958	NP_000949	P35408	PE2R4_HUMAN	prostaglandin E receptor 4, subtype EP4	399	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			lung(2)	2						TGCCAGACCTCTCACTGCCAG	0.572													0	0	0	0.016723	0	12	124										G	40692210	C	G	40692210	2	3	126	1	0	0	0	0	0	0	0	1	12745	900	32	1		1	PTGER4	5	40692210	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1774542	40692210	140223050	174	37472										
CARD6	84674	broad.mit.edu	37	chr5	40843437	40843437	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggacaagaaaactagttataGggaaacagctttgtctgcca	10	7	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:40843437G>C	uc003jmg.2	+	2	542	c.467G>C	c.(466-468)AGG>ACG	p.R156T		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	156					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						ACTAGTTATAGGGAAACAGCT	0.418													0	0	0	0.009096	0	4	73										C	40843437	G	C	40843437	3	2	126	1	0	0	0	0	1	0	0	0	2650	1000	35	4	473	4	CARD6	5	40843437	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	151227	40843437	140071823	175	37473										
HEXB	3074	broad.mit.edu	37	chr5	74014165	74014165	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agggatccattgtctggcagGaggtttttgatgataaagca	13	5	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:74014165G>C	uc003kdf.3	+	10	1336	c.1219G>C	c.(1219-1221)GAG>CAG	p.E407Q	HEXB_uc003kdd.2_Missense_Mutation_p.E182Q|HEXB_uc010izh.2_RNA|HEXB_uc003kdg.1_RNA|HEXB_uc010izi.1_RNA	NM_000521	NP_000512	P07686	HEXB_HUMAN	hexosaminidase B preproprotein	407					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		TGTCTGGCAGGAGGTTTTTGA	0.328													0	0	0	0.020292	0	11	44										C	74014165	G	C	74014165	3	2	126	1	0	0	0	0	1	0	0	0	7074	1175	41	1	1257	1	HEXB	5	74014165	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	33170728	74014165	106901095	176	37474										
GFM2	84340	broad.mit.edu	37	chr5	74054712	74054712	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atccggaatagtacaatattCtttctgtggtggtagttttg	10	5	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:74054712C>T	uc003kdh.1	-	5	570	c.266G>A	c.(265-267)AGA>AAA	p.R89K	GFM2_uc003kdi.1_Missense_Mutation_p.R89K|GFM2_uc010izj.1_Missense_Mutation_p.R121K|GFM2_uc010izk.1_RNA|GFM2_uc003kdj.1_Missense_Mutation_p.R89K|GFM2_uc010izl.1_Missense_Mutation_p.R89K	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	89					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		GTACAATATTCTTTCTGTGGT	0.358													0	0	0	0.009096	0	3	32										T	74054712	C	T	74054712	3	4	126	1	0	0	0	0	1	0	0	0	6342	913	32	1	2173	1	GFM2	5	74054712	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	40547	74054712	106860548	177	37475										
POC5	134359	broad.mit.edu	37	chr5	74990490	74990490	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaaagaagacctcatcttttCtcccaatggagatttcaaag	6	9	4	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:74990490C>T	uc003keh.3	-	6	877	c.680G>A	c.(679-681)AGA>AAA	p.R227K	POC5_uc010izu.2_Missense_Mutation_p.R110K|POC5_uc003keg.3_Missense_Mutation_p.R202K	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	227					cell cycle	centriole				lung(1)	1						CTCATCTTTTCTCCCAATGGA	0.294													0	0	0	0.014758	0	5	25										T	74990490	C	T	74990490	3	4	126	1	0	0	0	0	1	0	0	0	12177	913	32	1	1075	1	POC5	5	74990490	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	935778	74990490	105924770	178	37476										
GPR98	84059	broad.mit.edu	37	chr5	90281315	90281315	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcatcagagcatgtcacagaTctatggactcattcatggtg	9	9	6	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:90281315T>A	uc003kju.2	+	85	18224	c.18128T>A	c.(18127-18129)ATC>AAC	p.I6043N	GPR98_uc003kjt.2_Missense_Mutation_p.I3749N|GPR98_uc003kjw.2_Missense_Mutation_p.I1704N|GPR98_uc003kjx.2_Missense_Mutation_p.I71N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	6043	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCACAGATCTATGGACTC	0.423													0	0	0	0.004007	0	14	16										A	90281315	T	A	90281315	3	1	126	1	0	0	0	0	1	0	0	0	6721	1435	50	5	18466	5	GPR98	5	90281315	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	15290825	90281315	90633945	179	37477										
TRIM36	55521	broad.mit.edu	37	chr5	114473227	114473227	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttagaggagtcaattgctttCaaaacagatgatttcctctc	7	8	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:114473227C>G	uc003kqs.2	-	6	1463	c.954G>C	c.(952-954)TTG>TTC	p.L318F	TRIM36_uc011cwc.1_Missense_Mutation_p.L306F|TRIM36_uc003kqt.2_Missense_Mutation_p.L163F	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	318	Potential.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		CAATTGCTTTCAAAACAGATG	0.368													0	0	0	0.00623	0	40	76										G	114473227	C	G	114473227	3	3	126	1	0	0	0	0	1	0	0	0	16507	825	29	1	1252	1	TRIM36	5	114473227	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	24191912	114473227	66442033	180	37478										
LRRTM2	26045	broad.mit.edu	37	chr5	138209627	138209627	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtgctctaggtgaagctctCtcagtttaattaatcctgca	8	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:138209627C>T	uc011cyz.1	-	2	1080	c.623G>A	c.(622-624)AGA>AAA	p.R208K	CTNNA1_uc003ldh.2_Intron|CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Intron|LRRTM2_uc010jez.2_Intron|LRRTM2_uc011cza.1_Missense_Mutation_p.R74K|CTNNA1_uc003ldl.2_5'Flank	NM_015564	NP_056379	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	208	Extracellular (Potential).|LRR 7.					cell junction|integral to membrane|postsynaptic membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTGAAGCTCTCTCAGTTTAAT	0.448													0	0	0	0.01441	0	159	17										T	138209627	C	T	138209627	3	4	126	1	0	0	0	0	1	0	0	0	9040	913	32	1	931	1	LRRTM2	5	138209627	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	23736400	138209627	42705633	181	37479										
DND1	373863	broad.mit.edu	37	chr5	140052881	140052881	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggtggcccgccatacttcctCtgcccgttcacctgcaccag	9	18	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140052881C>T	uc003lgt.2	-	2	161	c.117G>A	c.(115-117)CAG>CAA	p.Q39Q		NM_194249	NP_919225	Q8IYX4	DND1_HUMAN	dead end homolog 1	39					multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATACTTCCTCTGCCCGTTCA	0.667													0	0	0	0.007291	0	25	71										T	140052881	C	T	140052881	2	4	126	1	0	0	0	0	0	0	0	1	4666	912	32	1		1	DND1	5	140052881	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1843254	140052881	40862379	182	37480										
PCDHA2	56146	broad.mit.edu	37	chr5	140176232	140176232	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgctggacgagaacgacaaCgcgccggcactgttggcgcc	15	13	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140176232C>T	uc003lhd.2	+	1	1789	c.1683C>T	c.(1681-1683)AAC>AAT	p.N561N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.N561N|PCDHA2_uc011czy.1_Silent_p.N561N	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	561	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGACAACGCGCCGGCAC	0.692													0	0	0	0.00632	0	25	71										T	140176232	C	T	140176232	2	4	126	1	0	0	0	0	0	0	0	1	11524	535	19	2		2	PCDHA2	5	140176232	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	123351	140176232	40739028	183	37481										
PCDHA4	56144	broad.mit.edu	37	chr5	140187223	140187223	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatccaggccgcttgactctCggtttccactagagggcgcc	11	14	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140187223C>G	uc003lhi.2	+	1	552	c.451C>G	c.(451-453)CGG>GGG	p.R151G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.R151G|PCDHA4_uc011daa.1_Missense_Mutation_p.R151G	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	151	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTGACTCTCGGTTTCCACT	0.542													0	0	0	0.014758	0	5	87										G	140187223	C	G	140187223	3	3	126	1	0	0	0	0	1	0	0	0	11526	875	31	1	453	1	PCDHA4	5	140187223	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	10991	140187223	40728037	184	37482										
PCDHA9	9752	broad.mit.edu	37	chr5	140229336	140229336	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctggaccgcgagagtgtgtCcgcctacgagctggtggtta	15	10	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140229336C>T	uc003lhu.2	+	1	1980	c.1256C>T	c.(1255-1257)TCC>TTC	p.S419F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.S419F	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	419	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAGTGTGTCCGCCTACGAG	0.637													0	0	0	0.012213	0	33	101										T	140229336	C	T	140229336	3	4	126	1	0	0	0	0	1	0	0	0	11531	855	30	1	1258	1	PCDHA9	5	140229336	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	42113	140229336	40685924	185	37483										
PCDHAC2	56134	broad.mit.edu	37	chr5	140348186	140348186	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caaagtcatagctatggactCagactctgggcaaaatgctt	9	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140348186C>A	uc003lii.2	+	1	2075	c.1835C>A	c.(1834-1836)TCA>TAA	p.S612*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Nonsense_Mutation_p.S612*	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	612	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTATGGACTCAGACTCTGGG	0.507													1	0	2.35188e-11	0.006122	3.20289e-11	17	31										A	140348186	C	A	140348186	4	1	126	1	0	0	0	0	0	1	0	0	11533	838	29	3	1837	3	PCDHAC2	5	140348186	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	118850	140348186	40567074	186	37484										
PCDHGA10	56106	broad.mit.edu	37	chr5	140793480	140793480	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatgacaacgcgccggtcttCaccttgccagaataccgagt	9	13	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:140793480C>T	uc003lkl.1	+	1	738	c.738C>T	c.(736-738)TTC>TTT	p.F246F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.F246F	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	246	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCGGTCTTCACCTTGCCAG	0.582													0	0	0	0.008291	0	9	34										T	140793480	C	T	140793480	2	4	126	1	0	0	0	0	0	0	0	1	11551	825	29	1		1	PCDHGA10	5	140793480	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	445294	140793480	40121780	187	37485										
JAKMIP2	9832	broad.mit.edu	37	chr5	147015815	147015815	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agctcctggtttctcttaatGaaaagttgtttatcttctac	6	8	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:147015815G>A	uc003loq.1	-	12	2029	c.1647C>T	c.(1645-1647)TTC>TTT	p.F549F	JAKMIP2_uc011dbx.1_Silent_p.F507F|JAKMIP2_uc003lor.1_Intron|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Silent_p.F549F	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	549	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCTTAATGAAAAGTTGTT	0.468													0	0	0	0.001984	0	6	14										A	147015815	G	A	147015815	2	1	126	1	0	0	0	0	0	0	0	1	7941	1281	45	1		1	JAKMIP2	5	147015815	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6222335	147015815	33899445	188	37486										
FAM71B	153745	broad.mit.edu	37	chr5	156589870	156589870	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtttttatggccagatgcgGaccggtgggaagacgctttc	14	8	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:156589870G>T	uc003lwn.2	-	2	1506	c.1406C>A	c.(1405-1407)TCC>TAC	p.S469Y		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	469						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCCAGATGCGGACCGGTGGGA	0.532													1	0	2.27054e-47	0.01441	3.22472e-47	130	22										T	156589870	G	T	156589870	3	4	126	1	0	0	0	0	1	0	0	0	5608	1174	41	3	415	3	FAM71B	5	156589870	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	9574055	156589870	24325390	189	37487										
ODZ2	57451	broad.mit.edu	37	chr5	167625892	167625892	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caaatggaggtgcttccttgActctacactttgagcgagcc	10	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:167625892A>T	uc010jjd.2	+	16	2908	c.2908A>T	c.(2908-2910)ACT>TCT	p.T970S	ODZ2_uc003lzr.3_Missense_Mutation_p.T747S|ODZ2_uc003lzt.3_Missense_Mutation_p.T343S|ODZ2_uc010jje.2_Missense_Mutation_p.T241S	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		TGCTTCCTTGACTCTACACTT	0.547													0	0	0	0.01441	0	45	26										T	167625892	A	T	167625892	3	4	126	1	0	0	0	0	1	0	0	0	10835	275	10	5	2970	5	ODZ2	5	167625892	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	11036022	167625892	13289368	190	37488										
CDHR2	54825	broad.mit.edu	37	chr5	176008383	176008383	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgggcaccaacaacagccgtCtgctcttcaacctgctgcct	8	17	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176008383C>G	uc003mem.1	+	17	1924	c.1858C>G	c.(1858-1860)CTG>GTG	p.L620V	CDHR2_uc003men.1_Missense_Mutation_p.L620V	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	620	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CAACAGCCGTCTGCTCTTCAA	0.632													0	0	0	0.019004	0	34	9										G	176008383	C	G	176008383	3	3	126	1	0	0	0	0	1	0	0	0	3119	912	32	1	1920	1	CDHR2	5	176008383	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8382491	176008383	4906877	191	37489										
UNC5A	90249	broad.mit.edu	37	chr5	176304243	176304243	+	Missense_Mutation	SNP	G	G	A													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	taccccgagggaagatctatGagatctacctcacgctgcac							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176304243G>A	uc003mey.2	+	9	1621	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	477	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAAGATCTATGAGATCTACCT	0.642													0	0	0	0.021523	0	23	45										A	176304243	G	A	176304243	3	1	126	1	0	0	0	0	1	0	0	0	16988	1291	45	1	1463	1	UNC5A	5	176304243	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	295860	176304243	4611017	192	37490	195	2								
UNC5A	90249	broad.mit.edu	37	chr5	176304245	176304245	+	Silent	SNP	G	G	A													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccccgagggaagatctatgaGatctacctcacgctgcacaa							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176304245G>A	uc003mey.2	+	9	1623	c.1431G>A	c.(1429-1431)GAG>GAA	p.E477E		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	477	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGATCTATGAGATCTACCTCA	0.642													0	0	0	0.021523	0	24	42										A	176304245	G	A	176304245	2	1	126	1	0	0	0	0	0	0	0	1	16988	933	33	1		1	UNC5A	5	176304245	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2	176304245	4611015	193	37491	195	2								
FAM193B	54540	broad.mit.edu	37	chr5	176952002	176952002	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attgctgtccatgctgagctCacacacactgaagctggcac	9	13	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:176952002C>G	uc003mhs.3	-	8	2970	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	FAM193B_uc003mhr.2_5'UTR|FAM193B_uc003mht.2_Missense_Mutation_p.E120Q|FAM193B_uc003mhu.2_Missense_Mutation_p.E173Q|FAM193B_uc003mhv.2_Missense_Mutation_p.E120Q|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	494											0						ATGCTGAGCTCACACACACTG	0.572													0	0	0	0.009096	0	4	91										G	176952002	C	G	176952002	3	3	126	1	0	0	0	0	1	0	0	0	5525	835	29	1	1000	1	FAM193B	5	176952002	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	647757	176952002	3963258	194	37492										
FAM153C	653316	broad.mit.edu	37	chr5	177468711	177468711	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	taggtgacctggaagacctgGaggagcatctgccagggcag	16	9	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr5:177468711G>A	uc011dge.1	+	7	352	c.151G>A	c.(151-153)GAG>AAG	p.E51K	FAM153C_uc003mig.1_Missense_Mutation_p.E51K	NM_001079527	NP_001072995			hypothetical protein LOC653316												0	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAAGACCTGGAGGAGCATCT	0.522													0	0	0	0.01441	0	61	168										A	177468711	G	A	177468711	3	1	126	1	0	0	0	0	1	0	0	0	5462	1175	41	1	169	1	FAM153C	5	177468711	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	516709	177468711	3446549	195	37493										
EXOC2	55770	broad.mit.edu	37	chr6	592509	592509	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccctctttgcaactgtgcatGagctgaaggatccacttgtg	10	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:592509G>C	uc003mtd.2	-	11	1286	c.1152C>G	c.(1150-1152)CTC>CTG	p.L384L	EXOC2_uc003mte.2_Silent_p.L384L|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	384					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		AACTGTGCATGAGCTGAAGGA	0.468													0	0	0	0.007413	0	19	46										C	592509	G	C	592509	2	2	126	1	0	0	0	0	0	0	0	1	5302	1277	45	1		1	EXOC2	6	592509	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		592509	170522558	196	37494										
HIST1H4D	8360	broad.mit.edu	37	chr6	26188994	26188994	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgtactgtagaggtaagctCagccgccgaagccataaaga	12	9	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:26188994C>T	uc003ngu.2	-	1	311	c.311G>A	c.(310-312)TGA>TAA	p.*104*		NM_003539	NP_003530	P62805	H4_HUMAN	histone cluster 1, H4d	104					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.196)				GAGGTAAGCTCAGCCGCCGAA	0.537													0	0	0	0.01892	0	22	69										T	26188994	C	T	26188994	2	4	126	1	0	0	0	0	0	0	0	1	7168	837	29	1		1	HIST1H4D	6	26188994	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	25596485	26188994	144926073	197	37495										
BTN3A1	11119	broad.mit.edu	37	chr6	26413833	26413833	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggatcgcatattcatactttCctggacgtctccttctctga	7	12	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:26413833C>T	uc003nhv.2	+	10	1823	c.1455C>T	c.(1453-1455)TTC>TTT	p.F485F	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Silent_p.F433F|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	485	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TTCATACTTTCCTGGACGTCT	0.463													0	0	0	0.00632	0	29	127										T	26413833	C	T	26413833	2	4	126	1	0	0	0	0	0	0	0	1	1562	854	30	1		1	BTN3A1	6	26413833	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	224839	26413833	144701234	198	37496										
BTN3A1	11119	broad.mit.edu	37	chr6	26413848	26413848	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actttcctggacgtctccttCtctgaggctctatatcctgt	7	13	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:26413848C>G	uc003nhv.2	+	10	1838	c.1470C>G	c.(1468-1470)TTC>TTG	p.F490L	BTN3A1_uc011dkj.1_3'UTR|BTN3A1_uc011dkk.1_Missense_Mutation_p.F438L|BTN3A1_uc010jqj.2_3'UTR	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	490	Cytoplasmic (Potential).|B30.2/SPRY.				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACGTCTCCTTCTCTGAGGCTC	0.458													0	0	0	0.009535	0	32	113										G	26413848	C	G	26413848	3	3	126	1	0	0	0	0	1	0	0	0	1562	912	32	1	1672	1	BTN3A1	6	26413848	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	15	26413848	144701219	199	37497										
BAT2	7916	broad.mit.edu	37	chr6	31600510	31600510	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacccaaggctgtgggaactCctgggggaggtggaggtgga	19	8	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:31600510C>G	uc003nvb.3	+	16	4309	c.4060C>G	c.(4060-4062)CCT>GCT	p.P1354A	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.P1354A	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1354	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TGTGGGAACTCCTGGGGGAGG	0.582													0	0	0	0.016522	0	24	89										G	31600510	C	G	31600510	3	3	126	1	0	0	0	0	1	0	0	0	1319	855	30	1	4118	1	BAT2	6	31600510	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	5186662	31600510	139514557	200	37498										
BAT2	7916	broad.mit.edu	37	chr6	31600529	31600529	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcctgggggaggtggaggtgGagccgtaccaggtatttcag	18	7	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:31600529G>C	uc003nvb.3	+	16	4328	c.4079G>C	c.(4078-4080)GGA>GCA	p.G1360A	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.G1360A	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1360	4 X 57 AA type A repeats.|Poly-Gly.					cytoplasm|nucleus	protein binding				0						GGTGGAGGTGGAGCCGTACCA	0.592													0	0	0	0.01441	0	85	49										C	31600529	G	C	31600529	3	2	126	1	0	0	0	0	1	0	0	0	1319	1174	41	1	4137	1	BAT2	6	31600529	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	19	31600529	139514538	201	37499										
RXRB	6257	broad.mit.edu	37	chr6	33165552	33165552	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tccttaccctccctcttcatGccagtggccaggcacttctg	7	17	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:33165552G>A	uc003odb.2	-	4	986	c.807C>T	c.(805-807)GGC>GGT	p.G269G	RXRB_uc003odc.2_Silent_p.G269G|RXRB_uc003odd.2_Silent_p.G173G|RXRB_uc011dqr.1_Silent_p.G79G|RXRB_uc011dqs.1_Silent_p.G152G|RXRB_uc003ode.1_Silent_p.G133G|RXRB_uc011dqt.1_Silent_p.G269G|RXRB_uc011dqu.1_Silent_p.G173G	NM_021976	NP_068811	P28702	RXRB_HUMAN	retinoid X receptor, beta	269	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			ovary(3)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Bexarotene(DB00307)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CCCTCTTCATGCCAGTGGCCA	0.577													0	0	0	0.00308	0	7	64										A	33165552	G	A	33165552	2	1	126	1	0	0	0	0	0	0	0	1	13764	1306	46	2		2	RXRB	6	33165552	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1565023	33165552	137949515	202	37500										
DEF6	50619	broad.mit.edu	37	chr6	35265694	35265694	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctttaccgcgctggacgtgGagaagagtggcaaagtctcc	13	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:35265694G>C	uc003okk.2	+	1	100	c.61G>C	c.(61-63)GAG>CAG	p.E21Q	DEF6_uc010jvs.2_Missense_Mutation_p.E21Q|DEF6_uc010jvt.2_5'UTR	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	21						cytoplasm|nucleus|plasma membrane					0						GCTGGACGTGGAGAAGAGTGG	0.672													0	0	0	0.004482	0	8	37										C	35265694	G	C	35265694	3	2	126	1	0	0	0	0	1	0	0	0	4386	1175	41	1	63	1	DEF6	6	35265694	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2100142	35265694	135849373	203	37501										
TULP1	7287	broad.mit.edu	37	chr6	35471540	35471540	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacagctgccagctcctgccGaaggcttgccacattagtgc	10	15	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:35471540G>A	uc003okv.3	-	12	1210	c.1198C>T	c.(1198-1200)CGG>TGG	p.R400W	TULP1_uc003okw.3_Missense_Mutation_p.R347W	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	400			R -> W (in LCA15).		dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						AGCTCCTGCCGAAGGCTTGCC	0.597													0	0	0	0.014323	0	21	7										A	35471540	G	A	35471540	3	1	126	1	0	0	0	0	1	0	0	0	16770	1057	37	1	446	1	TULP1	6	35471540	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	205846	35471540	135643527	204	37502										
PNPLA1	285848	broad.mit.edu	37	chr6	36259282	36259282	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcacccgcttaacggacgggGagaatgtggtggtttcagag	15	8	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:36259282G>A	uc010jwf.2	+	2	391	c.391G>A	c.(391-393)GAG>AAG	p.E131K	PNPLA1_uc003olw.1_Missense_Mutation_p.E36K|PNPLA1_uc010jwe.1_Missense_Mutation_p.E36K	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	131	Patatin.				lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						AACGGACGGGGAGAATGTGGT	0.637													0	0	0	0.014758	0	5	34										A	36259282	G	A	36259282	3	1	126	1	0	0	0	0	1	0	0	0	12164	1175	41	1	397	1	PNPLA1	6	36259282	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	787742	36259282	134855785	205	37503										
C6orf129	154467	broad.mit.edu	37	chr6	37451064	37451064	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgaagaaacttcagttccttCtctgggaggaaagagggtga	13	7	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:37451064C>T	uc003ont.2	-	4	253	c.192G>A	c.(190-192)GAG>GAA	p.E64E		NM_138493	NP_612502	Q9P0B6	CF129_HUMAN	hypothetical protein LOC154467	64	Potential.					integral to membrane					0						TCAGTTCCTTCTCTGGGAGGA	0.532													0	0	0	0.001168	0	6	74										T	37451064	C	T	37451064	2	4	126	1	0	0	0	0	0	0	0	1	2328	927	32	1		1	C6orf129	6	37451064	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1191782	37451064	133664003	206	37504										
UNC5CL	222643	broad.mit.edu	37	chr6	41002620	41002620	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggctggcaggtgctgccttGagacctcattttctagttgg	13	9	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:41002620G>C	uc003opi.2	-	2	283	c.194C>G	c.(193-195)TCA>TGA	p.S65*	UNC5CL_uc010jxe.1_Nonsense_Mutation_p.S65*	NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	65	Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTGCTGCCTTGAGACCTCATT	0.587													0	0	0	0.01892	0	24	131										C	41002620	G	C	41002620	4	2	126	1	0	0	0	0	0	1	0	0	16991	1294	45	1	1394	1	UNC5CL	6	41002620	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3551556	41002620	130112447	207	37505										
CNPY3	10695	broad.mit.edu	37	chr6	42902239	42902239	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatatgttgctgtggagctgAagtcagcctttgaggaaacc	12	7	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:42902239A>C	uc003ota.3	+	2	627	c.178A>C	c.(178-180)AAG>CAG	p.K60Q	CNPY3_uc003osy.2_RNA|CNPY3_uc003osz.2_Missense_Mutation_p.K60Q|CNPY3_uc003otc.3_5'UTR|CNPY3_uc003otb.3_Intron	NM_006586	NP_006577	Q9BT09	CNPY3_HUMAN	trinucleotide repeat containing 5 precursor	60	Saposin B-type.				innate immune response	endoplasmic reticulum				ovary(1)	1	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			TGTGGAGCTGAAGTCAGCCTT	0.537													0	0	0	0.006122	0	19	53										C	42902239	A	C	42902239	3	2	126	1	0	0	0	0	1	0	0	0	3629	247	9	5	184	5	CNPY3	6	42902239	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1899619	42902239	128212828	208	37506										
CUL7	9820	broad.mit.edu	37	chr6	43006375	43006375	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgaggggcccaatcgcctgaTtgagcatgtctgcggagagc	15	10	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:43006375T>C	uc003otq.2	-	24	4799	c.4496A>G	c.(4495-4497)AAT>AGT	p.N1499S	CUL7_uc010jyg.2_Missense_Mutation_p.N778S|CUL7_uc011dvb.1_Missense_Mutation_p.N1583S|CUL7_uc010jyh.2_Missense_Mutation_p.N492S|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1499					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AATCGCCTGATTGAGCATGTC	0.587													0	0	0	0.004656	0	26	89										C	43006375	T	C	43006375	3	2	126	1	0	0	0	0	1	0	0	0	4060	1493	52	5	612	5	CUL7	6	43006375	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	104136	43006375	128108692	209	37507										
COL21A1	81578	broad.mit.edu	37	chr6	56044893	56044893	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acactataagagccatctaaGatgaaaactaaatctgtcgg	7	8	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:56044893G>C	uc003pcs.2	-	3	355	c.123C>G	c.(121-123)ATC>ATG	p.I41M	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.I41M|COL21A1_uc003pcu.1_Missense_Mutation_p.I41M	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	41	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGCCATCTAAGATGAAAACTA	0.348													0	0	0	0.001984	0	6	9										C	56044893	G	C	56044893	3	2	126	1	0	0	0	0	1	0	0	0	3680	932	33	1	2862	1	COL21A1	6	56044893	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	13038518	56044893	115070174	210	37508										
RIMS1	22999	broad.mit.edu	37	chr6	72678707	72678707	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtgttgtcagggacatggcGaagcctgctgcctgcaaaac	13	10	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:72678707G>A	uc003pga.2	+	2	263	c.186G>A	c.(184-186)GCG>GCA	p.A62A		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	62	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGGACATGGCGAAGCCTGCTG	0.453													0	0	0	0.01441	0	46	43										A	72678707	G	A	72678707	2	1	126	1	0	0	0	0	0	0	0	1	13367	1045	37	1		1	RIMS1	6	72678707	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	16633814	72678707	98436360	211	37509										
GJB7	375519	broad.mit.edu	37	chr6	87994088	87994088	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgaggtgatgaccaagaaGaggatgaagatcgtcttctc	12	7	2	7			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:87994088G>A	uc003plo.2	-	3	889	c.543C>T	c.(541-543)CTC>CTT	p.L181L		NM_198568	NP_940970	Q6PEY0	CXB7_HUMAN	gap junction protein, beta 7, 25kDa	181	Helical; (Potential).				cell communication	connexon complex|integral to membrane					0		all_cancers(76;1.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;7.38e-10)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00323)		BRCA - Breast invasive adenocarcinoma(108;0.0167)		TGACCAAGAAGAGGATGAAGA	0.398													0	0	0	0.010729	0	12	30										A	87994088	G	A	87994088	2	1	126	1	0	0	0	0	0	0	0	1	6413	929	33	1		1	GJB7	6	87994088	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	15315381	87994088	83120979	212	37510										
EPHA7	2045	broad.mit.edu	37	chr6	93965737	93965737	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcctactaactgaatgactgTaaattgcccatcatgtttct	5	10	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:93965737T>C	uc003poe.2	-	13	2432	c.2191A>G	c.(2191-2193)ACA>GCA	p.T731A	EPHA7_uc003pof.2_Missense_Mutation_p.T726A|EPHA7_uc011eac.1_Missense_Mutation_p.T727A	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	731	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGAATGACTGTAAATTGCCCA	0.398													0	0	0	0.009096	0	3	21										C	93965737	T	C	93965737	3	2	126	1	0	0	0	0	1	0	0	0	5172	1638	57	5	825	5	EPHA7	6	93965737	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	5971649	93965737	77149330	213	37511										
FAM54A	113115	broad.mit.edu	37	chr6	136564027	136564027	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagataactggcttcttcatCatttgccacatacaaaatat	5	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:136564027C>G	uc010kgp.1	-	4	643	c.253G>C	c.(253-255)GAT>CAT	p.D85H	FAM54A_uc003qgt.1_Missense_Mutation_p.D85H|FAM54A_uc003qgu.1_Missense_Mutation_p.D42H	NM_001099286	NP_001092756	Q6P444	FA54A_HUMAN	DUF729 domain containing 1	85										skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)		GCTTCTTCATCATTTGCCACA	0.358													0	0	0	0.004672	0	3	78										G	136564027	C	G	136564027	3	3	126	1	0	0	0	0	1	0	0	0	5582	826	29	1	924	1	FAM54A	6	136564027	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	42598290	136564027	34551040	214	37512										
STXBP5	134957	broad.mit.edu	37	chr6	147648324	147648324	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctccagaaagcagtgctgctCaacctgggcactattgaatt	9	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:147648324C>G	uc003qlz.2	+	18	2153	c.1992C>G	c.(1990-1992)CTC>CTG	p.L664L	STXBP5_uc010khz.1_Silent_p.L664L|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.L335L|STXBP5_uc003qma.2_Silent_p.L11L	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	664	WD 10.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		CAGTGCTGCTCAACCTGGGCA	0.428													0	0	0	0.021523	0	24	48										G	147648324	C	G	147648324	2	3	126	1	0	0	0	0	0	0	0	1	15355	813	29	1		1	STXBP5	6	147648324	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	11084297	147648324	23466743	215	37513										
EZR	7430	broad.mit.edu	37	chr6	159206483	159206483	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatctcatcgctaaggattcCttccttcacttggaggaaga	9	10	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:159206483C>G	uc003qrt.3	-	4	540	c.325G>C	c.(325-327)GGA>CGA	p.G109R	EZR_uc011efs.1_Missense_Mutation_p.G77R|EZR_uc003qru.3_Missense_Mutation_p.G109R	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	109	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		CTAAGGATTCCTTCCTTCACT	0.532													0	0	0	0.001984	0	6	51										G	159206483	C	G	159206483	3	3	126	1	0	0	0	0	1	0	0	0	5335	690	24	4	1475	4	EZR	6	159206483	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	11558159	159206483	11908584	216	37514										
PNLDC1	154197	broad.mit.edu	37	chr6	160237614	160237614	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgaagccgcgtatgatgcctTcctctgtgggtcaggtaagg	14	10	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:160237614T>G	uc003qsx.1	+	14	1238	c.1067T>G	c.(1066-1068)TTC>TGC	p.F356C	PNLDC1_uc003qsy.1_Missense_Mutation_p.F367C	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	356	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TATGATGCCTTCCTCTGTGGG	0.378													0	0	0	0.008361	0	25	76										G	160237614	T	G	160237614	3	3	126	1	0	0	0	0	1	0	0	0	12148	1783	62	5	1117	5	PNLDC1	6	160237614	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	1031131	160237614	10877453	217	37515										
LPA	4018	broad.mit.edu	37	chr6	160999635	160999635	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcgattctgtcactggacatCgtgtcaggttgcagtactcc	10	11	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr6:160999635C>T	uc003qtl.2	-	28	4511	c.4391G>A	c.(4390-4392)CGA>CAA	p.R1464Q		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3972	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CACTGGACATCGTGTCAGGTT	0.527													0	0	0	0.010504	0	21	43										T	160999635	C	T	160999635	3	4	126	1	0	0	0	0	1	0	0	0	8903	884	31	1	1783	1	LPA	6	160999635	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	762021	160999635	10115432	218	37516										
SDK1	221935	broad.mit.edu	37	chr7	4107520	4107520	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagagatcttggacacatctCtcaaggtcagctggcaggag	12	10	4	1	rs142269128		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:4107520C>G	uc003smx.2	+	20	3101	c.2962C>G	c.(2962-2964)CTC>GTC	p.L988V	SDK1_uc010kso.2_Missense_Mutation_p.L264V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	988	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGACACATCTCTCAAGGTCAG	0.423													0	0	0	0.014758	0	5	35										G	4107520	C	G	4107520	3	3	126	1	0	0	0	0	1	0	0	0	13968	913	32	1	3040	1	SDK1	7	4107520	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		4107520	155031143	219	37517										
CYTH3	9265	broad.mit.edu	37	chr7	6227347	6227347	+	Silent	SNP	C	C	T													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acctctgcaatttcatatttCagcctctgtcaaaaaagaag							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:6227347C>T	uc003spt.2	-	3	227	c.123G>A	c.(121-123)CTG>CTA	p.L41L		NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	41	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						TTTCATATTTCAGCCTCTGTC	0.418													0	0	0	0.012319	0	21	87										T	6227347	C	T	6227347	2	4	126	1	0	0	0	0	0	0	0	1	4205	813	29	1		1	CYTH3	7	6227347	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2119827	6227347	152911316	220	37518	196	2								
CYTH3	9265	broad.mit.edu	37	chr7	6227353	6227353	+	Splice_Site	SNP	C	C	T													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcaatttcatatttcagcctCtgtcaaaaaagaagaatttc							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:6227353C>T	uc003spt.2	-	3	222	c.118_splice	c.e3-1	p.R40_splice		NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						ATTTCAGCCTCTGTCAAAAAA	0.433													0	0	0	0.008871	0	20	79										T	6227353	C	T	6227353	5	4	126	1	0	0	0	0	0	0	1	0	4205	927	32	1	1126	1	CYTH3	7	6227353	Splice_Site	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6	6227353	152911310	221	37519	196	2								
FAM126A	84668	broad.mit.edu	37	chr7	23030703	23030703	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaactctgacaaccattcctCcacaacccctttctctgaag	3	16	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:23030703C>T	uc003svm.3	-	2	283	c.28G>A	c.(28-30)GAG>AAG	p.E10K	FAM126A_uc003svn.3_Intron|FAM126A_uc011jyr.1_Missense_Mutation_p.E10K	NM_032581	NP_115970	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	10						cytoplasm|membrane	signal transducer activity			central_nervous_system(1)	1						AACCATTCCTCCACAACCCCT	0.303													0	0	0	0.010729	0	9	32										T	23030703	C	T	23030703	3	4	126	1	0	0	0	0	1	0	0	0	5429	864	30	1	1577	1	FAM126A	7	23030703	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	16803350	23030703	136107960	222	37520										
CREB5	9586	broad.mit.edu	37	chr7	28858828	28858828	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctacttcctcatcggtcagcGaggtggtaggaagctccacc	11	13	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:28858828G>T	uc003szq.2	+	11	1849	c.1459G>T	c.(1459-1461)GAG>TAG	p.E487*	CREB5_uc003szo.2_Nonsense_Mutation_p.E454*|CREB5_uc003szr.2_Nonsense_Mutation_p.E480*|CREB5_uc003szs.2_Nonsense_Mutation_p.E348*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	487					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						ATCGGTCAGCGAGGTGGTAGG	0.532													1	0	1.75199e-13	0.007291	2.39776e-13	28	107										T	28858828	G	T	28858828	4	4	126	1	0	0	0	0	0	1	0	0	3860	1059	37	3	1552	3	CREB5	7	28858828	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5828125	28858828	130279835	223	37521										
GLI3	2737	broad.mit.edu	37	chr7	42005202	42005202	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gttccactgaatgggcaggtCggttttgctgccctcggggc	15	11	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:42005202C>T	uc011kbh.1	-	15	3560	c.3469G>A	c.(3469-3471)GAC>AAC	p.D1157N	GLI3_uc011kbg.1_Missense_Mutation_p.D1098N	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1157					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATGGGCAGGTCGGTTTTGCTG	0.692									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.01441	0	55	245										T	42005202	C	T	42005202	3	4	126	1	0	0	0	0	1	0	0	0	6439	884	31	1	1277	1	GLI3	7	42005202	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	13146374	42005202	117133461	224	37522										
ZNF117	51351	broad.mit.edu	37	chr7	64439571	64439571	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctagtttggattcttttatgTtgagttaggtgtgaaagcat	11	3	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:64439571T>A	uc003ttr.2	-	4	1663	c.378A>T	c.(376-378)CAA>CAT	p.Q126H		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	126	C2H2-type 1; degenerate.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				TTCTTTTATGTTGAGTTAGGT	0.308													0	0	0	0.001168	0	6	15										A	64439571	T	A	64439571	3	1	126	1	0	0	0	0	1	0	0	0	17714	1722	60	5	1077	5	ZNF117	7	64439571	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	22434369	64439571	94699092	225	37523										
C7orf42	55069	broad.mit.edu	37	chr7	66409968	66409968	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttcactttcccaaaggattgGaatacttttctgctacggtt	7	9	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:66409968G>A	uc003tvk.2	+	3	429	c.165G>A	c.(163-165)TGG>TGA	p.W55*	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Nonsense_Mutation_p.W55*	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	55						integral to membrane				ovary(1)	1						CAAAGGATTGGAATACTTTTC	0.473													0	0	0	0.008291	0	9	71										A	66409968	G	A	66409968	4	1	126	1	0	0	0	0	0	1	0	0	2392	1183	41	1	171	1	C7orf42	7	66409968	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1970397	66409968	92728695	226	37524										
WBSCR17	64409	broad.mit.edu	37	chr7	70886021	70886021	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cggcccacgggtacagctggGagctgtggtgcatgtacatc	15	11	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:70886021G>A	uc003tvy.2	+	5	892	c.892G>A	c.(892-894)GAG>AAG	p.E298K	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	298	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GTACAGCTGGGAGCTGTGGTG	0.597													0	0	0	0.01441	0	52	83										A	70886021	G	A	70886021	3	1	126	1	0	0	0	0	1	0	0	0	17261	1175	41	1	910	1	WBSCR17	7	70886021	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4476053	70886021	88252642	227	37525										
POM121	9883	broad.mit.edu	37	chr7	72413873	72413873	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagtgggagctttgggatcaAtgtggccaccccaggctcca	13	12	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:72413873A>G	uc003twk.2	+	11	3341	c.3341A>G	c.(3340-3342)AAT>AGT	p.N1114S	POM121_uc003twj.2_Missense_Mutation_p.N849S|POM121_uc010lam.1_Missense_Mutation_p.N849S	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1114	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				TTTGGGATCAATGTGGCCACC	0.637													0	0	0	0.01441	0	54	17										G	72413873	A	G	72413873	3	3	126	1	0	0	0	0	1	0	0	0	12239	101	4	5	2584	5	POM121	7	72413873	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1527852	72413873	86724790	228	37526										
PHTF2	57157	broad.mit.edu	37	chr7	77549772	77549772	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacaggaacactgaggaatgGtcctagcaaagtacgtgtga	12	8	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:77549772G>C	uc003ugs.3	+	9	1079	c.953G>C	c.(952-954)GGT>GCT	p.G318A	PHTF2_uc003ugo.3_Missense_Mutation_p.G280A|PHTF2_uc003ugp.2_Missense_Mutation_p.G280A|PHTF2_uc003ugq.3_Missense_Mutation_p.G280A|PHTF2_uc010ldv.2_Missense_Mutation_p.G280A|PHTF2_uc003ugr.3_Missense_Mutation_p.G284A|PHTF2_uc003ugt.3_Missense_Mutation_p.G284A|PHTF2_uc003ugu.3_Missense_Mutation_p.G280A|PHTF2_uc003ugv.2_Missense_Mutation_p.G143A|PHTF2_uc010ldw.1_Missense_Mutation_p.G143A	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	318					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						CTGAGGAATGGTCCTAGCAAA	0.383													0	0	0	0.021022	0	35	23										C	77549772	G	C	77549772	3	2	126	1	0	0	0	0	1	0	0	0	11863	1261	44	4	881	4	PHTF2	7	77549772	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5135899	77549772	81588891	229	37527										
CYP51A1	1595	broad.mit.edu	37	chr7	91763582	91763582	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggcgatcagcagcatggacaAgaggttgccgcctgtcacct	13	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:91763582A>C	uc003ulm.3	-	1	259	c.97T>G	c.(97-99)TTG>GTG	p.L33V	CYP51A1_uc011khn.1_Intron|CYP51A1_uc003uln.3_Intron|uc003ulo.1_5'Flank	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	27	Helical; (Potential).				cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	AGCATGGACAAGAGGTTGCCG	0.687											OREG0018160	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	8	39										C	91763582	A	C	91763582	3	2	126	1	0	0	0	0	1	0	0	0	4195	69	3	5	1472	5	CYP51A1	7	91763582	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	14213810	91763582	67375081	230	37528										
CYP3A7	1551	broad.mit.edu	37	chr7	99319922	99319922	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcttccagaatactcaccccCagacttttctatacttttta	2	13	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:99319922C>T	uc003uru.2	-	3	320	c.215G>A	c.(214-216)TGG>TAG	p.W72*	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	72					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TACTCACCCCCAGACTTTTCT	0.388													0	0	0	0.001168	0	5	39										T	99319922	C	T	99319922	4	4	126	1	0	0	0	0	0	1	0	0	4181	595	21	2	1340	2	CYP3A7	7	99319922	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7556340	99319922	59818741	231	37529										
GATS	352954	broad.mit.edu	37	chr7	99821277	99821277	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaccacaggatggtgaactcTgatgacaacgtgtgggtgac	14	8	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:99821277T>A	uc003uua.3	-	4	705	c.456A>T	c.(454-456)TCA>TCT	p.S152S	GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc010lgt.2_RNA|GATS_uc011kjl.1_5'Flank|GATS_uc010lgu.2_RNA	NM_178831	NP_849153	Q8NAP1	GATS_HUMAN	GATS, stromal antigen 3 opposite strand	152											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGGTGAACTCTGATGACAACG	0.612													0	0	0	0.01441	0	49	217										A	99821277	T	A	99821277	2	1	126	1	0	0	0	0	0	0	0	1	6264	1567	55	5		5	GATS	7	99821277	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	501355	99821277	59317386	232	37530										
SRRT	51593	broad.mit.edu	37	chr7	100479836	100479836	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggcaacagatgcaggatttCttcctggcgcacaaagatga	11	9	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:100479836C>T	uc003uwy.2	+	6	829	c.561C>T	c.(559-561)TTC>TTT	p.F187F	SRRT_uc010lhl.1_Silent_p.F187F|SRRT_uc003uxa.2_Silent_p.F187F|SRRT_uc003uwz.2_Silent_p.F187F	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	187					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TGCAGGATTTCTTCCTGGCGC	0.587													0	0	0	0.008291	0	10	62										T	100479836	C	T	100479836	2	4	126	1	0	0	0	0	0	0	0	1	15171	912	32	1		1	SRRT	7	100479836	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	658559	100479836	58658827	233	37531										
MUC17	140453	broad.mit.edu	37	chr7	100680758	100680758	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcctgccaccacttctactGaaggcagttcatctcctaca	5	16	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:100680758G>A	uc003uxp.1	+	3	6114	c.6061G>A	c.(6061-6063)GAA>AAA	p.E2021K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2021	Extracellular (Potential).|32.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTTCTACTGAAGGCAGTTC	0.517													0	0	0	0.01441	0	67	290										A	100680758	G	A	100680758	3	1	126	1	0	0	0	0	1	0	0	0	9974	1291	45	1	6071	1	MUC17	7	100680758	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	200922	100680758	58457905	234	37532										
TRIM56	81844	broad.mit.edu	37	chr7	100730635	100730635	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccctccctcctggaggccctGagcagcgacttcctggcctg	11	18	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:100730635G>A	uc003uxq.2	+	3	273	c.42G>A	c.(40-42)CTG>CTA	p.L14L	TRIM56_uc003uxr.2_Silent_p.L14L	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	14					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					TGGAGGCCCTGAGCAGCGACT	0.622													0	0	0	0.008291	0	10	317										A	100730635	G	A	100730635	2	1	126	1	0	0	0	0	0	0	0	1	16527	1277	45	1		1	TRIM56	7	100730635	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	49877	100730635	58408028	235	37533										
TES	26136	broad.mit.edu	37	chr7	115889220	115889220	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtcagatggaattcccatgtAtaaacgcaatgttatgatat	8	6	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:115889220A>G	uc003vho.2	+	3	441	c.260A>G	c.(259-261)TAT>TGT	p.Y87C	TES_uc011kmx.1_Missense_Mutation_p.Y87C|TES_uc011kmy.1_Intron|TES_uc010lka.1_Missense_Mutation_p.Y78C|TES_uc003vhp.2_Missense_Mutation_p.Y78C	NM_015641	NP_056456	Q9UGI8	TES_HUMAN	testin isoform 1	87					negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding				0	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			ATTCCCATGTATAAACGCAAT	0.403													0	0	0	0.005443	0	25	37										G	115889220	A	G	115889220	3	3	126	1	0	0	0	0	1	0	0	0	15762	449	16	5	270	5	TES	7	115889220	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	15158585	115889220	43249443	236	37534										
PTPRZ1	5803	broad.mit.edu	37	chr7	121651654	121651654	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttacttcagctaccgagagtGataaggtgcccttgcatgct	10	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:121651654G>A	uc003vjy.2	+	12	2949	c.2554G>A	c.(2554-2556)GAT>AAT	p.D852N	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	852	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TACCGAGAGTGATAAGGTGCC	0.473													0	0	0	0.008291	0	10	81										A	121651654	G	A	121651654	3	1	126	1	0	0	0	0	1	0	0	0	12814	1290	45	1	2600	1	PTPRZ1	7	121651654	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5762434	121651654	37487009	237	37535										
FAM71F1	84691	broad.mit.edu	37	chr7	128355536	128355536	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tagaaagacttggaggaaatCaaagaagacagtaaaagtca	10	4	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:128355536C>G	uc003vno.1	+	1	94	c.41C>G	c.(40-42)TCA>TGA	p.S14*	FAM71F1_uc010llo.1_Intron|FAM71F1_uc011koq.1_Intron|FAM71F1_uc003vnm.1_Intron|FAM71F1_uc003vnn.1_Intron|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Nonsense_Mutation_p.S14*	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	14										skin(1)	1						TGGAGGAAATCAAAGAAGACA	0.493													0	0	0	0.01441	0	53	58										G	128355536	C	G	128355536	4	3	126	1	0	0	0	0	0	1	0	0	5612	838	29	1	43	1	FAM71F1	7	128355536	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6703882	128355536	30783127	238	37536										
FAM71F1	84691	broad.mit.edu	37	chr7	128359081	128359081	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccaccaaagaccctaggattCttgtcacgcactgcctggta	8	14	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:128359081C>G	uc003vno.1	+	3	684	c.631C>G	c.(631-633)CTT>GTT	p.L211V	FAM71F1_uc010llo.1_Missense_Mutation_p.L112V|FAM71F1_uc011koq.1_Missense_Mutation_p.L103V|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.L112V|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.L211V	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	211										skin(1)	1						CCCTAGGATTCTTGTCACGCA	0.542													0	0	0	0.01441	0	80	63										G	128359081	C	G	128359081	3	3	126	1	0	0	0	0	1	0	0	0	5612	913	32	1	641	1	FAM71F1	7	128359081	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3545	128359081	30779582	239	37537										
EZH2	2146	broad.mit.edu	37	chr7	148526869	148526870	+	Missense_Mutation	DNP	GA	GA	AT													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttttttattagttcttcaatGaaagtaccatcctgatctaa							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr7:148526869_148526870GA>AT	uc003wfd.1	-	5	600_601	c.434_435TC>AT	c.(433-435)TTC>TAT	p.F145Y	EZH2_uc011kug.1_Missense_Mutation_p.F136Y|EZH2_uc003wfb.1_Missense_Mutation_p.F145Y|EZH2_uc003wfc.1_Missense_Mutation_p.F106Y|EZH2_uc011kuh.1_Missense_Mutation_p.F136Y|EZH2_uc011kui.1_Missense_Mutation_p.F145Y|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	145	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.F145C(1)		haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			GTTCTTCAATGAAAGTACCATC	0.337			Mis		DLBCL								0	0	0	0.004672	0	12	59										AT	148526870	GA	AT	148526869	3	1	126	1	0	0	0	0	1	0	0	0	5334	1281	45	1	1884	1	EZH2	7	148526869	Missense_Mutation	DNP	GA	TCGA-H4-A2HQ-01A-11D-A17V-08	20167788	148526869	10611794	240	37538										
ERICH1	157697	broad.mit.edu	37	chr8	618727	618727	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggcagcatgctgtgtgacgCaaggcggtccagcagctcct	15	12	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:618727C>T	uc003wph.2	-	5	1194	c.1129G>A	c.(1129-1131)GCG>ACG	p.A377T	ERICH1_uc011kwh.1_Missense_Mutation_p.A377T|ERICH1_uc003wpe.1_Missense_Mutation_p.A283T|ERICH1_uc003wpi.2_Missense_Mutation_p.A189T	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	377										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CTGTGTGACGCAAGGCGGTCC	0.517													0	0	0	0.006122	0	18	26										T	618727	C	T	618727	3	4	126	1	0	0	0	0	1	0	0	0	5230	710	25	2	210	2	ERICH1	8	618727	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		618727	145745295	241	37539										
SGK223	157285	broad.mit.edu	37	chr8	8234441	8234441	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccactgcacccccactgcaGagtcagggctgctcaggtag	12	15	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:8234441G>C	uc003wsh.3	-	2	1478	c.1478C>G	c.(1477-1479)TCT>TGT	p.S493C		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	493							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CCCCACTGCAGAGTCAGGGCT	0.642													0	0	0	0.008291	0	9	22										C	8234441	G	C	8234441	3	2	126	1	0	0	0	0	1	0	0	0	14210	942	33	1	2746	1	SGK223	8	8234441	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7615714	8234441	138129581	242	37540										
ADAM7	8756	broad.mit.edu	37	chr8	24324310	24324310	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attgtgttcccaatttctacAggggattcttcagaataaac	7	8	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:24324310A>C	uc003xeb.2	+	6	503	c.390_splice	c.e6-2	p.R130_splice	ADAM7_uc003xea.1_Splice_Site_p.R130_splice	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7						proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAATTTCTACAGGGGATTCTT	0.383													0	0	0	0.004482	0	8	15										C	24324310	A	C	24324310	5	2	126	1	0	0	0	0	0	0	1	0	251	202	7	5	410	5	ADAM7	8	24324310	Splice_Site	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	16089869	24324310	122039712	243	37541										
PRKDC	5591	broad.mit.edu	37	chr8	48803019	48803019	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagaaagccactgctttcaaAagtgaagactgggcttcagt	10	8	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:48803019A>C	uc003xqi.2	-	33	3927	c.3870T>G	c.(3868-3870)CTT>CTG	p.L1290L	PRKDC_uc003xqj.2_Silent_p.L1290L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1290					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTGCTTTCAAAAGTGAAGACT	0.383								NHEJ					0	0	0	0.014758	0	5	11										C	48803019	A	C	48803019	2	2	126	1	0	0	0	0	0	0	0	1	12521	1	1	5		5	PRKDC	8	48803019	Silent	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	24478709	48803019	97561003	244	37542										
CHD7	55636	broad.mit.edu	37	chr8	61655385	61655385	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcgtccatttataggcatgtCctcggcaccaagggaattga	10	10	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:61655385C>A	uc003xue.2	+	2	1871	c.1394C>A	c.(1393-1395)TCC>TAC	p.S465Y		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	465	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ATAGGCATGTCCTCGGCACCA	0.557													1	0	0.000274275	0.004482	0.000349923	9	39										A	61655385	C	A	61655385	3	1	126	1	0	0	0	0	1	0	0	0	3330	855	30	3	1396	3	CHD7	8	61655385	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	12852366	61655385	84708637	245	37543										
CHD7	55636	broad.mit.edu	37	chr8	61735064	61735064	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttcattttcctcctaaaggcGaaactgcattttagcagatg	7	9	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:61735064G>A	uc003xue.2	+	12	3437	c.2960G>A	c.(2959-2961)CGA>CAA	p.R987Q	CHD7_uc003xuf.2_Missense_Mutation_p.R100Q	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	987	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCCTAAAGGCGAAACTGCATT	0.343													0	0	0	0.001984	0	7	49										A	61735064	G	A	61735064	3	1	126	1	0	0	0	0	1	0	0	0	3330	1058	37	1	3002	1	CHD7	8	61735064	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	79679	61735064	84628958	246	37544										
CSPP1	79848	broad.mit.edu	37	chr8	68076741	68076741	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtgatgatgaaattcctatCaggcaagtttagaattgcag	10	5	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:68076741C>G	uc003xxi.2	+	24	2947	c.2916C>G	c.(2914-2916)ATC>ATG	p.I972M	CSPP1_uc003xxj.2_Missense_Mutation_p.I937M|CSPP1_uc003xxk.2_Missense_Mutation_p.I592M|CSPP1_uc010lyw.2_Missense_Mutation_p.I32M	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	972						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAATTCCTATCAGGCAAGTTT	0.368													0	0	0	0.013726	0	30	204										G	68076741	C	G	68076741	3	3	126	1	0	0	0	0	1	0	0	0	3962	816	29	1	3010	1	CSPP1	8	68076741	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6341677	68076741	78287281	247	37545										
PREX2	80243	broad.mit.edu	37	chr8	69011949	69011949	+	Frame_Shift_Del	DEL	T	T	-													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctggctaaaagtgatgagcaTtttgtacaaaactgtaccag							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:69011949delT	uc003xxv.1	+	23	2613	c.2586delT	c.(2584-2586)CATfs	p.H862fs	PREX2_uc003xxu.1_Frame_Shift_Del_p.H862fs|PREX2_uc011lez.1_Frame_Shift_Del_p.H797fs	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	862					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GTGATGAGCATTTTGTACAAA	0.289																		13	80	---	---								-	69011949	T	-	69011949	7	5	126	1	0	1	0	1	0	0	0	0	12477	1490	52	0	2676	0	PREX2	8	69011949	Frame_Shift_Del	DEL	T	TCGA-H4-A2HQ-01A-11D-A17V-08	935208	69011949	77352073	248	37546										
SULF1	23213	broad.mit.edu	37	chr8	70536209	70536209	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatttgtccatactcggcagAcacgttccttgtccgtcgaa	9	12	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:70536209A>G	uc010lza.1	+	15	2344	c.1627A>G	c.(1627-1629)ACA>GCA	p.T543A	SULF1_uc003xyd.2_Missense_Mutation_p.T543A|SULF1_uc003xye.2_Missense_Mutation_p.T543A|SULF1_uc003xyf.2_Missense_Mutation_p.T543A|SULF1_uc003xyg.2_Missense_Mutation_p.T543A|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	543					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TACTCGGCAGACACGTTCCTT	0.408													0	0	0	0.010818	0	29	138										G	70536209	A	G	70536209	3	3	126	1	0	0	0	0	1	0	0	0	15369	275	10	5	1669	5	SULF1	8	70536209	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1524260	70536209	75827813	249	37547										
SLCO5A1	81796	broad.mit.edu	37	chr8	70585512	70585512	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cattcctgttgccagagcatGcaggtggtgtcaatgactgc	12	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:70585512G>A	uc003xyl.2	-	10	2846	c.2139C>T	c.(2137-2139)TGC>TGT	p.C713C	SLCO5A1_uc010lzb.2_Silent_p.C658C|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	713	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			GCCAGAGCATGCAGGTGGTGT	0.478													0	0	0	0.00874	0	42	214										A	70585512	G	A	70585512	2	1	126	1	0	0	0	0	0	0	0	1	14731	1311	46	2		2	SLCO5A1	8	70585512	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	49303	70585512	75778510	250	37548										
ZFHX4	79776	broad.mit.edu	37	chr8	77767112	77767112	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaaaagggtcgtgcaagtctGgttccagaatacacgagcgc	12	9	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:77767112G>T	uc003yav.2	+	10	8207	c.7820G>T	c.(7819-7821)TGG>TTG	p.W2607L	ZFHX4_uc003yau.1_Missense_Mutation_p.W2652L|ZFHX4_uc003yaw.1_Missense_Mutation_p.W2607L	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2607	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTGCAAGTCTGGTTCCAGAAT	0.498										HNSCC(33;0.089)			1	0	3.83957e-06	0.016522	5.04629e-06	24	124										T	77767112	G	T	77767112	3	4	126	1	0	0	0	0	1	0	0	0	17632	1357	47	4	7989	4	ZFHX4	8	77767112	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7181600	77767112	68596910	251	37549										
DCAF4L2	138009	broad.mit.edu	37	chr8	88885180	88885180	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggccatgacggaggctccaGattctcgtgtagcagtcctg	13	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:88885180G>A	uc003ydz.2	-	1	1117	c.1020C>T	c.(1018-1020)ATC>ATT	p.I340I		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	340	WD 2.									ovary(1)	1						GGAGGCTCCAGATTCTCGTGT	0.592													0	0	0	0.00499	0	14	129										A	88885180	G	A	88885180	2	1	126	1	0	0	0	0	0	0	0	1	4272	932	33	1		1	DCAF4L2	8	88885180	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	11118068	88885180	57478842	252	37550										
SLC26A7	115111	broad.mit.edu	37	chr8	92301462	92301462	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccatatttggaatgggacatCatgttgccacaggtaataat	9	7	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:92301462C>A	uc003yex.2	+	4	570	c.292C>A	c.(292-294)CAT>AAT	p.H98N	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.H98N|SLC26A7_uc003yfa.2_Missense_Mutation_p.H98N	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	98	Extracellular (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AATGGGACATCATGTTGCCAC	0.378													1	0	0.000175454	0.010504	0.000224886	21	199										A	92301462	C	A	92301462	3	1	126	1	0	0	0	0	1	0	0	0	14522	826	29	3	298	3	SLC26A7	8	92301462	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3416282	92301462	54062560	253	37551										
KIAA1429	25962	broad.mit.edu	37	chr8	95508024	95508024	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggttctacatcctggtcactGagaggtaaagggtcacctga	12	9	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:95508024G>A	uc003ygo.1	-	19	4492	c.4479C>T	c.(4477-4479)CTC>CTT	p.L1493L	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1493					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			CCTGGTCACTGAGAGGTAAAG	0.388													0	0	0	0.016723	0	12	97										A	95508024	G	A	95508024	2	1	126	1	0	0	0	0	0	0	0	1	8231	1277	45	1		1	KIAA1429	8	95508024	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3206562	95508024	50855998	254	37552										
UBR5	51366	broad.mit.edu	37	chr8	103354706	103354706	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attttttccaaataccttatCaggccaccactgcaaatctt	3	12	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:103354706C>G	uc003ykr.1	-	9	1126	c.1093G>C	c.(1093-1095)GAT>CAT	p.D365H	UBR5_uc003yks.1_Missense_Mutation_p.D365H	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	365					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AATACCTTATCAGGCCACCAC	0.408													0	0	0	0.01892	0	24	144										G	103354706	C	G	103354706	3	3	126	1	0	0	0	0	1	0	0	0	16902	826	29	1	7510	1	UBR5	8	103354706	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7846682	103354706	43009316	255	37553										
PKHD1L1	93035	broad.mit.edu	37	chr8	110460594	110460594	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtatttgagtacccgcttaAtattcaaaatattaatccaa	4	7	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:110460594A>C	uc003yne.2	+	39	6103	c.5999A>C	c.(5998-6000)AAT>ACT	p.N2000T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2000	Extracellular (Potential).|IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TACCCGCTTAATATTCAAAAT	0.373										HNSCC(38;0.096)			0	0	0	0.014758	0	5	46										C	110460594	A	C	110460594	3	2	126	1	0	0	0	0	1	0	0	0	11972	101	4	5	6153	5	PKHD1L1	8	110460594	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	7105888	110460594	35903428	256	37554										
COL14A1	7373	broad.mit.edu	37	chr8	121211724	121211724	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tatccaaaattggcattttaAtcacagatggaaaatcccaa	5	8	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:121211724A>T	uc003yox.2	+	8	1061	c.796A>T	c.(796-798)ATC>TTC	p.I266F	COL14A1_uc003yoy.2_5'UTR|COL14A1_uc010mde.1_Intron	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	266	VWFA 1.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGCATTTTAATCACAGATGG	0.383													0	0	0	0.00308	0	8	46										T	121211724	A	T	121211724	3	4	126	1	0	0	0	0	1	0	0	0	3671	101	4	5	822	5	COL14A1	8	121211724	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	10751130	121211724	25152298	257	37555										
C8orf76	84933	broad.mit.edu	37	chr8	124253563	124253563	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagtcctcgaactcgccgccGaacaaccagcacccggaatc	9	17	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:124253563G>A	uc003yqc.1	-	1	55	c.24C>T	c.(22-24)TTC>TTT	p.F8F	C8orf76_uc003yqd.2_Intron	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	8							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ACTCGCCGCCGAACAACCAGC	0.716													0	0	0	0.010729	0	10	49										A	124253563	G	A	124253563	2	1	126	1	0	0	0	0	0	0	0	1	2437	1049	37	1		1	C8orf76	8	124253563	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3041839	124253563	22110459	258	37556										
ATAD2	29028	broad.mit.edu	37	chr8	124392872	124392872	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttttctcaaagatcttaaagCacgtgtccggtggtaggttt	10	7	2	1	rs148295369		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:124392872C>G	uc003yqh.3	-	2	325	c.217G>C	c.(217-219)GCT>CCT	p.A73P	ATAD2_uc011lii.1_5'UTR|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.A73P	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	73					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GATCTTAAAGCACGTGTCCGG	0.358													0	0	0	0.001984	0	7	153										G	124392872	C	G	124392872	3	3	126	1	0	0	0	0	1	0	0	0	1071	710	25	4	4063	4	ATAD2	8	124392872	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	139309	124392872	21971150	259	37557										
KLHL38	340359	broad.mit.edu	37	chr8	124664510	124664510	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tactgcagcctgacctgcttGaacagttcctgcatgtatcg	9	12	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:124664510G>C	uc003yqs.1	-	1	681	c.657C>G	c.(655-657)TTC>TTG	p.F219L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	219	BACK.										0						TGACCTGCTTGAACAGTTCCT	0.557													0	0	0	0.012319	0	23	155										C	124664510	G	C	124664510	3	2	126	1	0	0	0	0	1	0	0	0	8390	1281	45	1	1100	1	KLHL38	8	124664510	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	271638	124664510	21699512	260	37558										
FAM49B	51571	broad.mit.edu	37	chr8	130883726	130883726	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttataaatttccttctcagaCtctgtaggctgggcatctaa	7	9	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:130883726C>G	uc003yss.2	-	7	639	c.90G>C	c.(88-90)GAG>GAC	p.E30D	FAM49B_uc003yst.2_Missense_Mutation_p.E30D|FAM49B_uc003ysu.2_Missense_Mutation_p.E30D|FAM49B_uc003ysv.2_5'UTR|FAM49B_uc003ysw.2_Missense_Mutation_p.E30D|FAM49B_uc003ysx.2_Missense_Mutation_p.E30D|FAM49B_uc003ysy.1_Missense_Mutation_p.E30D	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	30											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			CCTTCTCAGACTCTGTAGGCT	0.383													0	0	0	0.008291	0	9	59										G	130883726	C	G	130883726	3	3	126	1	0	0	0	0	1	0	0	0	5576	564	20	4	920	4	FAM49B	8	130883726	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6219216	130883726	15480296	261	37559										
LRRC6	23639	broad.mit.edu	37	chr8	133645151	133645151	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgatttgtggttcaattactGaatagtcctgcaatgcctta	8	7	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:133645151G>T	uc003ytk.2	-	5	562	c.488C>A	c.(487-489)TCA>TAA	p.S163*	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	163						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTCAATTACTGAATAGTCCTG	0.363													1	0	5.43694e-19	0.005524	7.59154e-19	39	89										T	133645151	G	T	133645151	4	4	126	1	0	0	0	0	0	1	0	0	9016	1294	45	3	944	3	LRRC6	8	133645151	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2761425	133645151	12718871	262	37560										
TG	7038	broad.mit.edu	37	chr8	134146952	134146952	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgggcagtcagcagagagtGaagaggaggagttgacggct	19	6	1	4	rs35054972		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:134146952G>A	uc003ytw.2	+	48	8262	c.8221G>A	c.(8221-8223)GAA>AAA	p.E2741K	TG_uc010mdw.2_Missense_Mutation_p.E1500K|TG_uc011ljb.1_Missense_Mutation_p.E1110K|TG_uc011ljc.1_Missense_Mutation_p.E874K	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2741					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCAGAGAGTGAAGAGGAGGA	0.547													0	0	0	0.005443	0	26	58										A	134146952	G	A	134146952	3	1	126	1	0	0	0	0	1	0	0	0	15810	1291	45	1	8411	1	TG	8	134146952	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	501801	134146952	12217070	263	37561										
NDRG1	10397	broad.mit.edu	37	chr8	134251299	134251299	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggctgcgggtgccatccagaGaagtgacgctggaaccagag	16	10	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:134251299G>C	uc003yuh.2	-	16	1593	c.1007C>G	c.(1006-1008)TCT>TGT	p.S336C	NDRG1_uc003yue.1_Missense_Mutation_p.S51C|NDRG1_uc003yuf.1_Missense_Mutation_p.S147C|NDRG1_uc003yug.2_Missense_Mutation_p.S336C|NDRG1_uc010mee.2_Missense_Mutation_p.S255C|NDRG1_uc010mef.2_Missense_Mutation_p.S270C|NDRG1_uc011ljh.1_Missense_Mutation_p.S164C|NDRG1_uc011lji.1_Missense_Mutation_p.S83C|NDRG1_uc003yui.1_Intron	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	336					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			GCCATCCAGAGAAGTGACGCT	0.687													0	0	0	0.014758	0	5	41										C	134251299	G	C	134251299	3	2	126	1	0	0	0	0	1	0	0	0	10251	942	33	1	181	1	NDRG1	8	134251299	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	104347	134251299	12112723	264	37562										
FAM135B	51059	broad.mit.edu	37	chr8	139255208	139255208	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgaggaagtcggcttgcagtAcccagctccaaagaccaagt	11	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:139255208A>T	uc003yuy.2	-	7	817	c.646T>A	c.(646-648)TAC>AAC	p.Y216N	FAM135B_uc003yux.2_Missense_Mutation_p.Y117N|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	216										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCTTGCAGTACCCAGCTCCA	0.483										HNSCC(54;0.14)			0	0	0	0.013537	0	11	103										T	139255208	A	T	139255208	3	4	126	1	0	0	0	0	1	0	0	0	5449	391	14	5	3630	5	FAM135B	8	139255208	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	5003909	139255208	7108814	265	37563										
PTK2	5747	broad.mit.edu	37	chr8	141712710	141712710	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgctatctcctgaggtctatGattccatgaatctgtttggt	9	8	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:141712710G>C	uc003yvu.2	-	25	2556	c.2326C>G	c.(2326-2328)CAT>GAT	p.H776D	PTK2_uc011ljp.1_Missense_Mutation_p.H84D|PTK2_uc003yvo.2_Missense_Mutation_p.H404D|PTK2_uc011ljq.1_Missense_Mutation_p.H471D|PTK2_uc003yvp.2_Missense_Mutation_p.H444D|PTK2_uc003yvq.2_Missense_Mutation_p.H302D|PTK2_uc003yvr.2_Missense_Mutation_p.H716D|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Missense_Mutation_p.H798D|PTK2_uc003yvv.2_Missense_Mutation_p.H676D|PTK2_uc011ljr.1_Missense_Mutation_p.H776D	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	776	Interaction with TGFB1I1.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TGAGGTCTATGATTCCATGAA	0.453													0	0	0	0.012319	0	20	139										C	141712710	G	C	141712710	3	2	126	1	0	0	0	0	1	0	0	0	12762	1290	45	1	864	1	PTK2	8	141712710	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2457502	141712710	4651312	266	37564										
ZNF696	79943	broad.mit.edu	37	chr8	144378379	144378379	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagcgggcgcacagcggggaGaggccctacgcgtgcgccga	18	14	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:144378379G>A	uc003yxy.3	+	3	943	c.534G>A	c.(532-534)GAG>GAA	p.E178E		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			ACAGCGGGGAGAGGCCCTACG	0.697													0	0	0	0.00308	0	7	36										A	144378379	G	A	144378379	2	1	126	1	0	0	0	0	0	0	0	1	18096	933	33	1		1	ZNF696	8	144378379	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2665669	144378379	1985643	267	37565										
EEF1D	1936	broad.mit.edu	37	chr8	144662724	144662724	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttggccaccagtgcaggcttCttggccttcttctccgcgta	10	14	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr8:144662724C>T	uc011lki.1	-	6	833	c.564G>A	c.(562-564)AAG>AAA	p.K188K	NAPRT1_uc003yym.3_5'Flank|NAPRT1_uc003yyn.3_5'Flank|NAPRT1_uc011lkh.1_5'Flank|NAPRT1_uc003yyo.3_5'Flank|EEF1D_uc003yyp.1_Silent_p.K530K|EEF1D_uc003yyq.1_Silent_p.K604K|EEF1D_uc011lkj.1_Silent_p.K553K|EEF1D_uc003yyr.2_Silent_p.K554K|EEF1D_uc003yyt.2_Silent_p.K554K|EEF1D_uc011lkk.1_Silent_p.K188K|EEF1D_uc003yys.2_Silent_p.K188K|EEF1D_uc003yyv.2_Silent_p.K164K|EEF1D_uc003yyu.2_Silent_p.K188K|EEF1D_uc011lkl.1_Silent_p.K169K	NM_001130057	NP_001123529	P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta	188					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			ovary(1)|kidney(1)|skin(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GTGCAGGCTTCTTGGCCTTCT	0.637													0	0	0	0.006999	0	39	241										T	144662724	C	T	144662724	2	4	126	1	0	0	0	0	0	0	0	1	4926	912	32	1		1	EEF1D	8	144662724	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	284345	144662724	1701298	268	37566										
FRMPD1	22844	broad.mit.edu	37	chr9	37735728	37735728	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaagtgtatcttcaggacgtCaaggtaacacaatggggaga	12	6	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:37735728C>T	uc004aag.1	+	13	1442	c.1398C>T	c.(1396-1398)GTC>GTT	p.V466V	FRMPD1_uc004aah.1_Silent_p.V466V|FRMPD1_uc011lqm.1_Silent_p.V288V|FRMPD1_uc011lqn.1_Silent_p.V335V	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	466	FERM.					cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TTCAGGACGTCAAGGTAACAC	0.423													0	0	0	0.00874	0	42	3										T	37735728	C	T	37735728	2	4	126	1	0	0	0	0	0	0	0	1	6057	813	29	1		1	FRMPD1	9	37735728	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		37735728	103477703	269	37567										
FAM75C1	441452	broad.mit.edu	37	chr9	90535926	90535926	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catcttcaatcctctttcccAgtcctatctcctgcttttct	2	16	5	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:90535926A>C	uc010mqi.2	+	4	1133	c.1104A>C	c.(1102-1104)CCA>CCC	p.P368P	FAM75C1_uc004apq.3_Silent_p.P351P	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CCTCTTTCCCAGTCCTATCTC	0.537													0	0	0	0.01441	0	218	409										C	90535926	A	C	90535926	2	2	126	1	0	0	0	0	0	0	0	1	5623	175	7	5		5	FAM75C1	9	90535926	Silent	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	52800198	90535926	50677505	270	37568										
CTNNAL1	8727	broad.mit.edu	37	chr9	111745534	111745534	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tatccaatgccactttcataCggtcaaatactccttctttg	4	12	3	0	rs150483984	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:111745534C>T	uc004bdo.1	-	6	833	c.791G>A	c.(790-792)CGT>CAT	p.R264H	CTNNAL1_uc010mts.1_5'UTR|CTNNAL1_uc010mtt.1_Missense_Mutation_p.R264H|CTNNAL1_uc004bdp.1_Missense_Mutation_p.R264H	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	264					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		CACTTTCATACGGTCAAATAC	0.333													0	0	0	0.016723	0	10	46										T	111745534	C	T	111745534	3	4	126	1	0	0	0	0	1	0	0	0	4015	536	19	2	1469	2	CTNNAL1	9	111745534	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	21209608	111745534	29467897	271	37569										
PALM2-AKAP2	445815	broad.mit.edu	37	chr9	112642957	112642957	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agcaacttgaagataacattCagaggtaggtggcttccagc	11	8	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:112642957C>A	uc004bei.2	+	3	445	c.253C>A	c.(253-255)CAG>AAG	p.Q85K	PALM2_uc004bef.2_Missense_Mutation_p.Q87K|PALM2_uc004beg.2_Missense_Mutation_p.Q87K|PALM2_uc004beh.3_Missense_Mutation_p.Q85K|PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.Q85K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.Q85K|PALM2-AKAP2_uc004bel.1_5'UTR	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGATAACATTCAGAGGTAGGT	0.527													1	0	4.72057e-08	0.021523	6.28398e-08	26	18										A	112642957	C	A	112642957	3	1	126	1	0	0	0	0	1	0	0	0	11410	827	29	3	263	3	PALM2-AKAP2	9	112642957	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	897423	112642957	28570474	272	37570										
ZNF483	158399	broad.mit.edu	37	chr9	114304279	114304279	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccgcaaggagaaaaccgccgGagaaaagtcacggaaatcta	11	10	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:114304279G>C	uc004bff.2	+	6	1288	c.1064G>C	c.(1063-1065)GGA>GCA	p.G355A	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	355					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						AAAACCGCCGGAGAAAAGTCA	0.438													0	0	0	0.01441	0	105	7										C	114304279	G	C	114304279	3	2	126	1	0	0	0	0	1	0	0	0	17933	1174	41	1	1082	1	ZNF483	9	114304279	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1661322	114304279	26909152	273	37571										
COL27A1	85301	broad.mit.edu	37	chr9	116930564	116930564	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggacaggctgacacgtaccaGtccccactgggacctctctt	10	15	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:116930564G>A	uc011lxl.1	+	3	729	c.729G>A	c.(727-729)CAG>CAA	p.Q243Q	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Silent_p.Q93Q	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	243					cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ACACGTACCAGTCCCCACTGG	0.567													0	0	0	0.001984	0	7	162										A	116930564	G	A	116930564	2	1	126	1	0	0	0	0	0	0	0	1	3685	1020	36	2		2	COL27A1	9	116930564	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2626285	116930564	24282867	274	37572										
COL27A1	85301	broad.mit.edu	37	chr9	116931301	116931301	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccatttactgctttatcctCatctcctgcccctactcctg	3	18	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:116931301C>T	uc011lxl.1	+	3	1466	c.1466C>T	c.(1465-1467)TCA>TTA	p.S489L	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.S339L	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	489	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GCTTTATCCTCATCTCCTGCC	0.592													0	0	0	0.01441	0	165	254										T	116931301	C	T	116931301	3	4	126	1	0	0	0	0	1	0	0	0	3685	838	29	1	1476	1	COL27A1	9	116931301	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	737	116931301	24282130	275	37573										
TNFSF8	944	broad.mit.edu	37	chr9	117668133	117668133	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggtaggcccatgacttcttGaatggagcccttttcaggat	11	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:117668133G>C	uc004bji.1	-	3	472	c.285C>G	c.(283-285)TTC>TTG	p.F95L		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	95	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						ATGACTTCTTGAATGGAGCCC	0.413													0	0	0	0.01441	0	49	185										C	117668133	G	C	117668133	3	2	126	1	0	0	0	0	1	0	0	0	16308	1281	45	1	427	1	TNFSF8	9	117668133	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	736832	117668133	23545298	276	37574										
TNFSF8	944	broad.mit.edu	37	chr9	117668170	117668170	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggatacataagaggtcttctGagcaatttcctaaaaataag	8	6	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:117668170G>A	uc004bji.1	-	3	435	c.248C>T	c.(247-249)TCA>TTA	p.S83L		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	83	Extracellular (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GAGGTCTTCTGAGCAATTTCC	0.403													0	0	0	0.015359	0	31	144										A	117668170	G	A	117668170	3	1	126	1	0	0	0	0	1	0	0	0	16308	1294	45	1	464	1	TNFSF8	9	117668170	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	37	117668170	23545261	277	37575										
TNC	3371	broad.mit.edu	37	chr9	117800543	117800543	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttggacaaaaccttaccttTctcgcctgtgtaggagatga	9	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:117800543T>C	uc004bjj.3	-	20	5871	c.5509A>G	c.(5509-5511)AAA>GAA	p.K1837E	TNC_uc010mvf.2_Missense_Mutation_p.K1564E	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1837	Fibronectin type-III 14.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						ACCTTACCTTTCTCGCCTGTG	0.517													0	0	0	0.01441	0	82	94										C	117800543	T	C	117800543	3	2	126	1	0	0	0	0	1	0	0	0	16267	1792	62	5	1132	5	TNC	9	117800543	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	132373	117800543	23412888	278	37576										
GOLGA2	2801	broad.mit.edu	37	chr9	131020315	131020315	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggtctccccacacacagaatCacccccggtccctggggctg	10	18	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:131020315C>A	uc011maw.1	-	22	2384	c.2371G>T	c.(2371-2373)GAT>TAT	p.D791Y	GOLGA2_uc010mxw.2_Missense_Mutation_p.D114Y|GOLGA2_uc004buh.2_Missense_Mutation_p.D264Y	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	791	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						CACACAGAATCACCCCCGGTC	0.687													1	0	5.20837e-25	0.00874	7.32178e-25	41	63										A	131020315	C	A	131020315	3	1	126	1	0	0	0	0	1	0	0	0	6552	826	29	3	657	3	GOLGA2	9	131020315	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	13219772	131020315	10193116	279	37577										
ZER1	10444	broad.mit.edu	37	chr9	131504994	131504994	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcctcggggatgctgaagtTgcagagcgtcaggcagcagt	15	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:131504994T>C	uc004bwa.1	-	9	1823	c.1390A>G	c.(1390-1392)AAC>GAC	p.N464D		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	464	ARM 1.				ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						ATGCTGAAGTTGCAGAGCGTC	0.617													0	0	0	0.001168	0	6	32										C	131504994	T	C	131504994	3	2	126	1	0	0	0	0	1	0	0	0	17622	1812	63	5	942	5	ZER1	9	131504994	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	484679	131504994	9708437	280	37578										
USP20	10868	broad.mit.edu	37	chr9	132637006	132637006	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caccacctacgacctcctctCggtcatctgccaccacggca	6	20	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:132637006C>T	uc004bys.2	+	18	2103	c.1892C>T	c.(1891-1893)TCG>TTG	p.S631L	USP20_uc004byr.2_Missense_Mutation_p.S631L|USP20_uc004byt.1_Missense_Mutation_p.S631L	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	631					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)				GACCTCCTCTCGGTCATCTGC	0.647													0	0	0	0.01441	0	49	103										T	132637006	C	T	132637006	3	4	126	1	0	0	0	0	1	0	0	0	17049	893	31	1	1954	1	USP20	9	132637006	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1132012	132637006	8576425	281	37579										
SETX	23064	broad.mit.edu	37	chr9	135158707	135158707	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttgcccacggaaagcagactCaagtagtaaaccaccacttg	8	12	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:135158707C>G	uc004cbk.2	-	19	6673	c.6490G>C	c.(6490-6492)GAG>CAG	p.E2164Q	SETX_uc004cbj.2_Missense_Mutation_p.E1783Q|SETX_uc010mzt.2_Missense_Mutation_p.E1783Q	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2164					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AAAGCAGACTCAAGTAGTAAA	0.483													0	0	0	0.009096	0	4	116										G	135158707	C	G	135158707	3	3	126	1	0	0	0	0	1	0	0	0	14141	835	29	1	1575	1	SETX	9	135158707	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2521701	135158707	6054724	282	37580										
RXRA	6256	broad.mit.edu	37	chr9	137300887	137300887	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccgcgacaacaaggactgcCtgattgacaagcggcagcgg	14	12	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr9:137300887C>G	uc004cfb.2	+	4	694	c.532C>G	c.(532-534)CTG>GTG	p.L178V	RXRA_uc004cfc.1_Missense_Mutation_p.L81V	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	178	NR C4-type.|Nuclear receptor.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CAAGGACTGCCTGATTGACAA	0.627													0	0	0	0.001168	0	5	195										G	137300887	C	G	137300887	3	3	126	1	0	0	0	0	1	0	0	0	13763	680	24	4	546	4	RXRA	9	137300887	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2142180	137300887	3912544	283	37581										
MAPK8	5599	broad.mit.edu	37	chr10	49633979	49633979	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acagcttggaacaccatgtcCtgaattcatgaagaaactgc	8	10	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:49633979C>G	uc009xnz.2	+	8	961	c.737C>G	c.(736-738)CCT>CGT	p.P246R	MAPK8_uc001jgl.2_Missense_Mutation_p.P246R|MAPK8_uc001jgm.2_Missense_Mutation_p.P246R|MAPK8_uc001jgo.2_Missense_Mutation_p.P246R|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.P246R|MAPK8_uc010qgk.1_Missense_Mutation_p.P246R|MAPK8_uc001jgp.2_Missense_Mutation_p.P246R|MAPK8_uc001jgq.2_Missense_Mutation_p.P246R	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	246	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		ACACCATGTCCTGAATTCATG	0.343													0	0	0	0.020292	0	13	18										G	49633979	C	G	49633979	3	3	126	1	0	0	0	0	1	0	0	0	9283	681	24	4	839	4	MAPK8	10	49633979	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		49633979	85900768	284	37582										
CTNNA3	29119	broad.mit.edu	37	chr10	67829226	67829226	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aatcttttctttttctgcctCaggcagttgagtcatcttag	7	9	6	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:67829226C>T	uc009xpn.1	-	15	2122	c.1999G>A	c.(1999-2001)GAG>AAG	p.E667K	CTNNA3_uc001jmw.2_Missense_Mutation_p.E667K	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	667					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						TTTTCTGCCTCAGGCAGTTGA	0.348													0	0	0	0.001984	0	6	34										T	67829226	C	T	67829226	3	4	126	1	0	0	0	0	1	0	0	0	4014	835	29	1	704	1	CTNNA3	10	67829226	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	18195247	67829226	67705521	285	37583										
HNRNPH3	3189	broad.mit.edu	37	chr10	70099239	70099239	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggagctggtgatgcaagttCaggttttcatggtggtcatt	14	5	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:70099239C>T	uc001jnw.3	+	6	795	c.566C>T	c.(565-567)TCA>TTA	p.S189L	HNRNPH3_uc001jnx.3_Missense_Mutation_p.S174L|HNRNPH3_uc009xpu.2_Missense_Mutation_p.S58L|HNRNPH3_uc010qiv.1_Missense_Mutation_p.S81L|HNRNPH3_uc001jny.3_Missense_Mutation_p.S140L	NM_012207	NP_036339	P31942	HNRH3_HUMAN	heterogeneous nuclear ribonucleoprotein H3	189	Gly-rich.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2						GATGCAAGTTCAGGTTTTCAT	0.378													0	0	0	0.006122	0	17	35										T	70099239	C	T	70099239	3	4	126	1	0	0	0	0	1	0	0	0	7268	838	29	1	584	1	HNRNPH3	10	70099239	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2270013	70099239	65435508	286	37584										
ADAMTS14	140766	broad.mit.edu	37	chr10	72520585	72520585	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agacatcccggcaccagcctCcctgctgcctccccggtgac	9	20	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:72520585C>T	uc001jrh.2	+	22	3648	c.3648C>T	c.(3646-3648)CTC>CTT	p.L1216L	ADAMTS14_uc001jrg.2_Silent_p.L1219L	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1216	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GCACCAGCCTCCCTGCTGCCT	0.637													0	0	0	0.006122	0	18	23										T	72520585	C	T	72520585	2	4	126	1	0	0	0	0	0	0	0	1	259	842	30	1		1	ADAMTS14	10	72520585	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2421346	72520585	63014162	287	37585										
CDH23	64072	broad.mit.edu	37	chr10	73567089	73567089	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgagcactcaccacgcggcaCcctcgtgggcaacgtgacag	12	15	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:73567089C>T	uc001jrx.3	+	56	8611	c.8234C>T	c.(8233-8235)ACC>ATC	p.T2745I	CDH23_uc001jsg.3_Missense_Mutation_p.T505I|CDH23_uc001jsh.3_Missense_Mutation_p.T505I|CDH23_uc001jsi.3_Missense_Mutation_p.T505I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2745	Cadherin 26.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCACGCGGCACCCTCGTGGGC	0.627													0	0	0	0.003163	0	16	17										T	73567089	C	T	73567089	3	4	126	1	0	0	0	0	1	0	0	0	3108	507	18	2	8805	2	CDH23	10	73567089	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1046504	73567089	61967658	288	37586										
KIF20B	9585	broad.mit.edu	37	chr10	91477195	91477195	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttcagtcacagcatattcaCtgttaaaatattacagattg	5	7	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:91477195C>G	uc001kgs.1	+	10	1139	c.1067C>G	c.(1066-1068)ACT>AGT	p.T356S	KIF20B_uc001kgr.1_Missense_Mutation_p.T356S	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	356	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AGCATATTCACTGTTAAAATA	0.254													0	0	0	0.004672	0	2	4										G	91477195	C	G	91477195	3	3	126	1	0	0	0	0	1	0	0	0	8287	565	20	4	1101	4	KIF20B	10	91477195	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	17910106	91477195	44057552	289	37587										
ZNF518A	9849	broad.mit.edu	37	chr10	97919098	97919098	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcgtggaactgtgactaagGagccttgcaaaacacctatt	9	10	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:97919098G>C	uc001klp.2	+	6	3876	c.3019G>C	c.(3019-3021)GAG>CAG	p.E1007Q	ZNF518A_uc001klo.1_Missense_Mutation_p.E477Q|ZNF518A_uc001klq.2_Missense_Mutation_p.E1007Q|ZNF518A_uc001klr.2_Missense_Mutation_p.E1007Q	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1007					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TGTGACTAAGGAGCCTTGCAA	0.433													0	0	0	0.004672	0	3	23										C	97919098	G	C	97919098	3	2	126	1	0	0	0	0	1	0	0	0	17959	1175	41	1	3021	1	ZNF518A	10	97919098	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6441903	97919098	37615649	290	37588										
LCOR	84458	broad.mit.edu	37	chr10	98715326	98715326	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attcttggggctcagatgctGagcagtctacctctggacag	12	10	4	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:98715326G>C	uc001kms.1	+	8	1470	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	LCOR_uc001kmr.2_Missense_Mutation_p.E317Q|C10orf12_uc009xvg.1_Intron|LCOR_uc001kmt.1_Missense_Mutation_p.E317Q|LCOR_uc001kmu.1_Missense_Mutation_p.E317Q	NM_032440	NP_115816	Q96JN0	LCOR_HUMAN	ligand dependent nuclear receptor corepressor	317						nucleus	DNA binding			ovary(3)	3		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTCAGATGCTGAGCAGTCTAC	0.483													0	0	0	0.004007	0	15	11										C	98715326	G	C	98715326	3	2	126	1	0	0	0	0	1	0	0	0	8689	1291	45	1	959	1	LCOR	10	98715326	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	796228	98715326	36819421	291	37589										
RRP12	23223	broad.mit.edu	37	chr10	99160977	99160977	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acaccagaaggcaactttccCgagcgacccatgttgactaa	8	13	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:99160977C>T	uc001knf.2	-	1	151	c.12G>A	c.(10-12)TCG>TCA	p.S4S	RRP12_uc010qou.1_Silent_p.S4S|RRP12_uc009xvn.2_Silent_p.S4S	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	4						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GCAACTTTCCCGAGCGACCCA	0.587													0	0	0	0.006122	0	16	44										T	99160977	C	T	99160977	2	4	126	1	0	0	0	0	0	0	0	1	13686	639	23	2		2	RRP12	10	99160977	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	445651	99160977	36373770	292	37590										
PKD2L1	9033	broad.mit.edu	37	chr10	102057272	102057272	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actaccctgtcgggatcctgGaaggtccaggtagtagccac	12	12	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:102057272G>A	uc001kqx.1	-	5	1206	c.823C>T	c.(823-825)CCA>TCA	p.P275S	PKD2L1_uc009xwm.1_Missense_Mutation_p.P228S	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	275	Extracellular (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CGGGATCCTGGAAGGTCCAGG	0.617													0	0	0	0.007291	0	27	43										A	102057272	G	A	102057272	3	1	126	1	0	0	0	0	1	0	0	0	11967	1174	41	1	1642	1	PKD2L1	10	102057272	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2896295	102057272	33477475	293	37591										
CPXM2	119587	broad.mit.edu	37	chr10	125506529	125506529	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggcgccagtaatccccatcGttggctgtgaaaaagaaaac	10	10	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr10:125506529G>T	uc001lhk.1	-	14	2347	c.2022C>A	c.(2020-2022)AAC>AAA	p.N674K	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	674					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		AATCCCCATCGTTGGCTGTGA	0.552													1	0	3.28513e-13	0.021523	4.48859e-13	24	208										T	125506529	G	T	125506529	3	4	126	1	0	0	0	0	1	0	0	0	3838	1136	40	4	252	4	CPXM2	10	125506529	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	23449257	125506529	10028218	294	37592										
IFITM3	10410	broad.mit.edu	37	chr11	319922	319922	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agaatcagggcccagatgttCaggcacttggcggtggaggc	16	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:319922C>T	uc001lpa.2	-	2	419	c.318G>A	c.(316-318)CTG>CTA	p.L106L	uc001loz.2_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	interferon-induced transmembrane protein 3	106	Cytoplasmic (Potential).				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane				central_nervous_system(7)	7		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCCAGATGTTCAGGCACTTGG	0.587													0	0	0	0.01441	0	48	48										T	319922	C	T	319922	2	4	126	1	0	0	0	0	0	0	0	1	7528	813	29	1		1	IFITM3	11	319922	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		319922	134686594	295	37593										
OR51I2	390064	broad.mit.edu	37	chr11	5474803	5474803	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctctcactcctggctgtcaGggcccctctgcgtgatgtat	11	14	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:5474803G>T	uc010qzf.1	+	1	85	c.85G>T	c.(85-87)GGG>TGG	p.G29W	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGCTGTCAGGGCCCCTCTG	0.547													1	0	9.31168e-06	0.016723	1.21418e-05	12	31										T	5474803	G	T	5474803	3	4	126	1	0	0	0	0	1	0	0	0	11101	1000	35	4	87	4	OR51I2	11	5474803	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5154881	5474803	129531713	296	37594										
NLRP10	338322	broad.mit.edu	37	chr11	7984932	7984932	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtgggggctggccctcagaCagggtcatatcccgtaagta	14	10	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:7984932C>T	uc001mfv.1	-	1	128	c.111G>A	c.(109-111)CTG>CTA	p.L37L		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	37	DAPIN.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGCCCTCAGACAGGGTCATAT	0.542													0	0	0	0.016522	0	25	52										T	7984932	C	T	7984932	2	4	126	1	0	0	0	0	0	0	0	1	10472	465	17	2		2	NLRP10	11	7984932	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2510129	7984932	127021584	297	37595										
RIC3	79608	broad.mit.edu	37	chr11	8132430	8132430	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gacagcaggatcctcgtcttCatgaaaacagcaggaacatg	10	10	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:8132430C>A	uc001mgd.2	-	6	979	c.925G>T	c.(925-927)GAA>TAA	p.E309*	RIC3_uc001mgb.2_Nonsense_Mutation_p.E147*|RIC3_uc001mgc.2_Nonsense_Mutation_p.E308*|RIC3_uc001mge.2_Nonsense_Mutation_p.E127*|RIC3_uc010rbl.1_Nonsense_Mutation_p.E259*|RIC3_uc010rbm.1_Nonsense_Mutation_p.E337*|RIC3_uc009yfm.2_Nonsense_Mutation_p.E228*|RIC3_uc009yfn.2_Nonsense_Mutation_p.E112*	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	309	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		TCCTCGTCTTCATGAAAACAG	0.493													1	0	1.60099e-16	0.021022	2.21675e-16	36	78										A	8132430	C	A	8132430	4	1	126	1	0	0	0	0	0	1	0	0	13354	835	29	3	188	3	RIC3	11	8132430	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	147498	8132430	126874086	298	37596										
MICALCL	84953	broad.mit.edu	37	chr11	12315578	12315578	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggaatgactccatccctgaGagtgtgcacctcaaagctgg	11	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:12315578G>C	uc001mkg.1	+	3	891	c.600G>C	c.(598-600)GAG>GAC	p.E200D		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	200					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		CCATCCCTGAGAGTGTGCACC	0.537													0	0	0	0.010818	0	31	85										C	12315578	G	C	12315578	3	2	126	1	0	0	0	0	1	0	0	0	9572	933	33	1	606	1	MICALCL	11	12315578	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4183148	12315578	122690938	299	37597										
DBX1	120237	broad.mit.edu	37	chr11	20178727	20178727	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agcatgccccgccgaggcttCccgcgcgcggccagcggcca	14	19	0	0	rs143300593	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:20178727C>T	uc001mpw.1	-	3	528	c.528G>A	c.(526-528)GGG>GGA	p.G176G		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	176					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCGAGGCTTCCCGCGCGCGG	0.682													0	0	0	0.001168	0	6	10										T	20178727	C	T	20178727	2	4	126	1	0	0	0	0	0	0	0	1	4259	842	30	1		1	DBX1	11	20178727	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7863149	20178727	114827789	300	37598										
QSER1	79832	broad.mit.edu	37	chr11	32955355	32955355	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccatcaggcatctcttcctAatacacaggtccttttagat	6	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:32955355A>G	uc001mty.2	+	4	2431	c.2164A>G	c.(2164-2166)AAT>GAT	p.N722D	QSER1_uc001mtz.1_Missense_Mutation_p.N483D|QSER1_uc001mua.2_Missense_Mutation_p.N227D	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	722	Gln-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ATCTCTTCCTAATACACAGGT	0.413													0	0	0	0.00308	0	8	21										G	32955355	A	G	32955355	3	3	126	1	0	0	0	0	1	0	0	0	12882	362	13	5	2170	5	QSER1	11	32955355	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	12776628	32955355	102051161	301	37599										
C11orf74	119710	broad.mit.edu	37	chr11	36654908	36654908	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttacctcagcaaaagttactCataaaaatgaagcagatgac	6	8	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:36654908C>T	uc001mwy.1	+	3	284	c.211C>T	c.(211-213)CAT>TAT	p.H71Y	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Intron|C11orf74_uc001mwx.1_Intron|C11orf74_uc001mwz.1_Intron|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	71											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				AAAAGTTACTCATAAAAATGA	0.338													0	0	0	0.001168	0	5	24										T	36654908	C	T	36654908	3	4	126	1	0	0	0	0	1	0	0	0	1662	826	29	1	217	1	C11orf74	11	36654908	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3699553	36654908	98351608	302	37600										
ZNF408	79797	broad.mit.edu	37	chr11	46726955	46726955	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acccacacacgctccgagctCacgagcgcctgcactccgga	9	19	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:46726955C>T	uc001nde.1	+	5	1935	c.1705C>T	c.(1705-1707)CAC>TAC	p.H569Y	ZNF408_uc010rgw.1_Missense_Mutation_p.H561Y	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	569	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GCTCCGAGCTCACGAGCGCCT	0.657													0	0	0	0.001984	0	6	30										T	46726955	C	T	46726955	3	4	126	1	0	0	0	0	1	0	0	0	17885	826	29	1	1755	1	ZNF408	11	46726955	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	10072047	46726955	88279561	303	37601										
PSMC3	5702	broad.mit.edu	37	chr11	47444417	47444417	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caggcccgggccaggagggtCttccccgtccctgggggccc	16	17	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:47444417C>G	uc001nfh.2	-	7	893	c.699G>C	c.(697-699)AAG>AAC	p.K233N	PSMC3_uc009ylr.1_Missense_Mutation_p.K191N	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	233	ATP (Potential).			K->H: Loss of function.	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCAGGAGGGTCTTCCCCGTCC	0.582													0	0	0	0.006214	0	8	198										G	47444417	C	G	47444417	3	3	126	1	0	0	0	0	1	0	0	0	12687	912	32	1	644	1	PSMC3	11	47444417	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	717462	47444417	87562099	304	37602										
NUP160	23279	broad.mit.edu	37	chr11	47819815	47819815	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atacatgtccttagagtagcCtaaatatcaaatgtagatca	6	7	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:47819815C>A	uc001ngm.2	-	25	3077	c.2992_splice	c.e25-1	p.A998_splice	NUP160_uc009ylw.2_Splice_Site	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						TTAGAGTAGCCTAAATATCAA	0.353													1	0	0.000157383	0.00308	0.000202036	8	40										A	47819815	C	A	47819815	5	1	126	1	0	0	0	0	0	0	1	0	10757	695	24	4	1367	4	NUP160	11	47819815	Splice_Site	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	375398	47819815	87186701	305	37603										
OR5T1	390155	broad.mit.edu	37	chr11	56043764	56043764	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attcttctactttgtgggctCtattgagatagtcactatcc	7	9	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:56043764C>A	uc001nio.1	+	1	650	c.650C>A	c.(649-651)TCT>TAT	p.S217Y		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTTGTGGGCTCTATTGAGATA	0.408													1	0	1.96292e-10	0.010504	2.65572e-10	21	97										A	56043764	C	A	56043764	3	1	126	1	0	0	0	0	1	0	0	0	11181	913	32	3	652	3	OR5T1	11	56043764	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8223949	56043764	78962752	306	37604										
CLP1	10978	broad.mit.edu	37	chr11	57427259	57427259	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacagccttggaacagatgcGgaggcaagcggaaaaggaag	15	8	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:57427259G>A	uc001nkw.2	+	2	450	c.311G>A	c.(310-312)CGG>CAG	p.R104Q	CLP1_uc010rjw.1_Missense_Mutation_p.R104Q|CLP1_uc009yml.2_Missense_Mutation_p.R104Q	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	104					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						GAACAGATGCGGAGGCAAGCG	0.547													0	0	0	0.021523	0	27	61										A	57427259	G	A	57427259	3	1	126	1	0	0	0	0	1	0	0	0	3550	1116	39	2	313	2	CLP1	11	57427259	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1383495	57427259	77579257	307	37605										
CTNND1	1500	broad.mit.edu	37	chr11	57569394	57569394	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggattccgcttggatgctgtCaagtccaatgcagctgcata	11	10	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:57569394C>G	uc001nmc.3	+	7	1717	c.1146C>G	c.(1144-1146)GTC>GTG	p.V382V	CTNND1_uc001nlh.1_Silent_p.V382V|CTNND1_uc001nlu.3_Silent_p.V281V|CTNND1_uc001nlt.3_Silent_p.V281V|CTNND1_uc001nls.3_Silent_p.V281V|CTNND1_uc001nlw.3_Silent_p.V281V|CTNND1_uc001nmf.3_Silent_p.V382V|CTNND1_uc001nmd.3_Silent_p.V328V|CTNND1_uc001nlk.3_Silent_p.V328V|CTNND1_uc001nme.3_Silent_p.V382V|CTNND1_uc001nll.3_Silent_p.V328V|CTNND1_uc001nmg.3_Silent_p.V328V|CTNND1_uc001nlj.3_Silent_p.V328V|CTNND1_uc001nlr.3_Silent_p.V328V|CTNND1_uc001nlp.3_Silent_p.V328V|CTNND1_uc001nlx.3_Silent_p.V59V|CTNND1_uc001nlz.3_Silent_p.V59V|CTNND1_uc009ymn.2_Silent_p.V59V|CTNND1_uc001nlm.3_Silent_p.V382V|CTNND1_uc001nly.3_Silent_p.V59V|CTNND1_uc001nmb.3_Silent_p.V59V|CTNND1_uc001nma.3_Silent_p.V59V|CTNND1_uc001nmi.3_Silent_p.V281V|CTNND1_uc001nmh.3_Silent_p.V382V|CTNND1_uc001nlq.3_Silent_p.V281V|CTNND1_uc001nln.3_Silent_p.V382V|CTNND1_uc001nli.3_Silent_p.V382V|CTNND1_uc001nlo.3_Silent_p.V281V|CTNND1_uc001nlv.3_Silent_p.V281V	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	382	ARM 1.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				TGGATGCTGTCAAGTCCAATG	0.552													0	0	0	0.004007	0	16	94										G	57569394	C	G	57569394	2	3	126	1	0	0	0	0	0	0	0	1	4019	813	29	1		1	CTNND1	11	57569394	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	142135	57569394	77437122	308	37606										
OR9Q1	219956	broad.mit.edu	37	chr11	57947582	57947582	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgtcctacctgtttatcatCgtggccatcatggggatccc	10	12	2	0	rs139135884	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:57947582C>G	uc001nmj.2	+	3	982	c.666C>G	c.(664-666)ATC>ATG	p.I222M		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TGTTTATCATCGTGGCCATCA	0.512													0	0	0	0.008361	0	26	93										G	57947582	C	G	57947582	3	3	126	1	0	0	0	0	1	0	0	0	11255	874	31	1	668	1	OR9Q1	11	57947582	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	378188	57947582	77058934	309	37607										
TMEM132A	54972	broad.mit.edu	37	chr11	60703933	60703933	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggtcttcgtcctgcgctatCagcgcaaagaacctcccgac	9	15	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:60703933C>T	uc001nqj.2	+	11	2819	c.2626C>T	c.(2626-2628)CAG>TAG	p.Q876*	TMEM132A_uc001nqi.2_Nonsense_Mutation_p.Q877*|TMEM132A_uc001nqm.2_Nonsense_Mutation_p.Q86*	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	876	Binds to HSPA5/GRP78 (By similarity).|Cytoplasmic (Potential).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CCTGCGCTATCAGCGCAAAGA	0.607													0	0	0	0.01441	0	55	233										T	60703933	C	T	60703933	4	4	126	1	0	0	0	0	0	1	0	0	16042	827	29	1	2671	1	TMEM132A	11	60703933	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2756351	60703933	74302583	310	37608										
TMEM216	51259	broad.mit.edu	37	chr11	61161357	61161357	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctggcttttgtattggcaggTgtcctgctaccatatccaac	9	11	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:61161357T>G	uc010rlj.1	+	3	410	c.117T>G	c.(115-117)GGT>GGG	p.G39G	TMEM216_uc001nrn.1_5'UTR	NM_016499	NP_057583	Q9P0N5	TM216_HUMAN	transmembrane protein 216	39						integral to membrane					0						TATTGGCAGGTGTCCTGCTAC	0.438													0	0	0	0.010818	0	17	67										G	61161357	T	G	61161357	2	3	126	1	0	0	0	0	0	0	0	1	16136	1710	59	5		5	TMEM216	11	61161357	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	457424	61161357	73845159	311	37609										
DAGLA	747	broad.mit.edu	37	chr11	61511216	61511216	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctgtacagcttcgactcgcGccgctcctcaggcttccgca	9	18	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:61511216G>A	uc001nsa.2	+	20	2495	c.2384G>A	c.(2383-2385)CGC>CAC	p.R795H		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	795	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TTCGACTCGCGCCGCTCCTCA	0.682													0	0	0	0.010818	0	33	126										A	61511216	G	A	61511216	3	1	126	1	0	0	0	0	1	0	0	0	4226	1087	38	2	2458	2	DAGLA	11	61511216	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	349859	61511216	73495300	312	37610										
MTA2	9219	broad.mit.edu	37	chr11	62364201	62364201	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggctgaccattcctccatctCatcccgacacagcaccgggc	8	18	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:62364201C>T	uc001ntq.1	-	9	1171	c.790G>A	c.(790-792)GAG>AAG	p.E264K	MTA2_uc010rlx.1_Missense_Mutation_p.E91K	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	264	SANT.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCCTCCATCTCATCCCGACAC	0.537													0	0	0	0.01441	0	69	142										T	62364201	C	T	62364201	3	4	126	1	0	0	0	0	1	0	0	0	9909	835	29	1	1256	1	MTA2	11	62364201	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	852985	62364201	72642315	313	37611										
PYGM	5837	broad.mit.edu	37	chr11	64522956	64522956	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcattgggagccttggcagaCcagaggcgcatggtgttgac	15	9	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:64522956C>A	uc001oax.3	-	6	1552	c.735G>T	c.(733-735)TGG>TGT	p.W245C	PYGM_uc001oay.3_Missense_Mutation_p.W157C	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	245					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CCTTGGCAGACCAGAGGCGCA	0.622													1	0	9.31168e-06	0.016723	1.21418e-05	12	85										A	64522956	C	A	64522956	3	1	126	1	0	0	0	0	1	0	0	0	12862	508	18	4	1853	4	PYGM	11	64522956	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2158755	64522956	70483560	314	37612										
MAP4K2	5871	broad.mit.edu	37	chr11	64557220	64557220	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acctgtgggccccaagcactCggaagatccttgtttcatct	9	13	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:64557220C>T	uc001obh.2	-	31	2449	c.2357G>A	c.(2356-2358)CGA>CAA	p.R786Q	MAP4K2_uc001obg.2_RNA|MAP4K2_uc001obi.2_Missense_Mutation_p.R778Q	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	786	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						CCCAAGCACTCGGAAGATCCT	0.592													0	0	0	0.00632	0	25	123										T	64557220	C	T	64557220	3	4	126	1	0	0	0	0	1	0	0	0	9260	884	31	1	113	1	MAP4K2	11	64557220	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	34264	64557220	70449296	315	37613										
C11orf2	738	broad.mit.edu	37	chr11	64875784	64875784	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgcacgcccgcggccggctgGagaaggagctgagaaacctg	16	13	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:64875784G>C	uc001ocr.1	+	5	881	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	C11orf2_uc001ocs.1_Missense_Mutation_p.E157Q	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	281	Potential.				lipid transport|protein transport	Golgi apparatus|integral to membrane					0						CGGCCGGCTGGAGAAGGAGCT	0.706													0	0	0	0.004482	0	8	45										C	64875784	G	C	64875784	3	2	126	1	0	0	0	0	1	0	0	0	1633	1175	41	1	859	1	C11orf2	11	64875784	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	318564	64875784	70130732	316	37614										
CDC42EP2	10435	broad.mit.edu	37	chr11	65088417	65088417	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagcgtggcagtcgcaagggCaagaaggagaagcttcggga	17	7	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:65088417C>T	uc001odl.2	+	2	498	c.48C>T	c.(46-48)GGC>GGT	p.G16G		NM_006779	NP_006770	O14613	BORG1_HUMAN	Cdc42 effector protein 2	16					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity				0						GTCGCAAGGGCAAGAAGGAGA	0.627													0	0	0	0.001168	0	6	58										T	65088417	C	T	65088417	2	4	126	1	0	0	0	0	0	0	0	1	3076	697	25	2		2	CDC42EP2	11	65088417	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	212633	65088417	69918099	317	37615										
PC	5091	broad.mit.edu	37	chr11	66619932	66619932	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccccagttctccatgctgaaGagcttgctgaagttgtgggc	12	11	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:66619932G>C	uc001ojn.1	-	13	1852	c.1803C>G	c.(1801-1803)CTC>CTG	p.L601L	PC_uc001ojo.1_Silent_p.L601L|PC_uc001ojp.1_Silent_p.L601L|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	601	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CCATGCTGAAGAGCTTGCTGA	0.622													0	0	0	0.001984	0	7	139										C	66619932	G	C	66619932	2	2	126	1	0	0	0	0	0	0	0	1	11497	929	33	1		1	PC	11	66619932	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1531515	66619932	68386584	318	37616										
CABP4	57010	broad.mit.edu	37	chr11	67223786	67223786	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acagagcttcaggccgccttCgaggagtttgacactgaccg	12	12	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:67223786C>T	uc001olo.2	+	3	491	c.414C>T	c.(412-414)TTC>TTT	p.F138F	CABP4_uc001oln.2_Silent_p.F33F	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	138	EF-hand 1.				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AGGCCGCCTTCGAGGAGTTTG	0.652													0	0	0	0.012213	0	29	163										T	67223786	C	T	67223786	2	4	126	1	0	0	0	0	0	0	0	1	2533	883	31	1		1	CABP4	11	67223786	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	603854	67223786	67782730	319	37617										
NUMA1	4926	broad.mit.edu	37	chr11	71726086	71726086	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccatactgtgcctcctcttgCtggctatcctcataccgctc	6	17	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:71726086C>A	uc001orl.1	-	15	2635	c.2463G>T	c.(2461-2463)CAG>CAT	p.Q821H	NUMA1_uc009ysw.1_Missense_Mutation_p.Q384H|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Missense_Mutation_p.Q821H|NUMA1_uc001orn.2_Missense_Mutation_p.Q384H|NUMA1_uc009ysx.1_Missense_Mutation_p.Q821H|NUMA1_uc001oro.1_Missense_Mutation_p.Q821H	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	821	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCTCCTCTTGCTGGCTATCCT	0.577			T	RARA	APL								1	0	1.99505e-19	0.012213	2.7951e-19	33	255										A	71726086	C	A	71726086	3	1	126	1	0	0	0	0	1	0	0	0	10750	796	28	4	3936	4	NUMA1	11	71726086	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4502300	71726086	63280430	320	37618										
FOLR2	2350	broad.mit.edu	37	chr11	71932735	71932735	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccatgcatgtgaatgctggtGagatgcttcatgggactggg	15	7	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:71932735G>C	uc009ytd.2	+	5	866	c.697G>C	c.(697-699)GAG>CAG	p.E233Q	FOLR2_uc009yte.2_Missense_Mutation_p.E233Q|FOLR2_uc001ose.3_Missense_Mutation_p.E233Q|FOLR2_uc009ytf.2_Missense_Mutation_p.E233Q	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	233					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)	GAATGCTGGTGAGATGCTTCA	0.587													0	0	0	0.013537	0	13	161										C	71932735	G	C	71932735	3	2	126	1	0	0	0	0	1	0	0	0	5982	1291	45	1	711	1	FOLR2	11	71932735	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	206649	71932735	63073781	321	37619										
ARRB1	408	broad.mit.edu	37	chr11	74977287	74977287	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgcctttcagtctctggcGagcaaagtcctcaaatacaa	7	12	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:74977287G>A	uc001owe.1	-	16	1399	c.1177C>T	c.(1177-1179)CGC>TGC	p.R393C	ARRB1_uc001owf.1_Missense_Mutation_p.R385C	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	393	Interaction with TRAF6.|[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif.			R->A: Abolishes interaction with AP2B1.	G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						AGTCTCTGGCGAGCAAAGTCC	0.547													0	0	0	0.00632	0	28	152										A	74977287	G	A	74977287	3	1	126	1	0	0	0	0	1	0	0	0	980	1058	37	1	83	1	ARRB1	11	74977287	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3044552	74977287	60029229	322	37620										
FAT3	120114	broad.mit.edu	37	chr11	92533025	92533025	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctagttaatgatgtaaatgaCaacccccctattttcgatca	5	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:92533025C>A	uc001pdj.3	+	9	6863	c.6846C>A	c.(6844-6846)GAC>GAA	p.D2282E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2282	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGTAAATGACAACCCCCCTA	0.423										TCGA Ovarian(4;0.039)			1	0	0.00024832	0.009096	0.000317298	4	14										A	92533025	C	A	92533025	3	1	126	1	0	0	0	0	1	0	0	0	5691	477	17	4	6880	4	FAT3	11	92533025	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	17555738	92533025	42473491	323	37621										
CASP5	838	broad.mit.edu	37	chr11	104877904	104877904	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgcaaagagtctaccaagatCagggccttgtcttcaatttt	8	10	4	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:104877904C>T	uc010rva.1	-	3	371	c.339G>A	c.(337-339)CTG>CTA	p.L113L	CASP5_uc010ruz.1_Silent_p.L126L|CASP5_uc010rvb.1_Silent_p.L55L|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_5'UTR|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	113	CARD.				apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		CTACCAAGATCAGGGCCTTGT	0.368													0	0	0	0.013537	0	12	26										T	104877904	C	T	104877904	2	4	126	1	0	0	0	0	0	0	0	1	2674	813	29	1		1	CASP5	11	104877904	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	12344879	104877904	30128612	324	37622										
RDX	5962	broad.mit.edu	37	chr11	110128893	110128893	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcttcccactgttcttttgtTagtttgtgttgttccaatac	6	9	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:110128893T>G	uc001pku.2	-	6	799	c.489A>C	c.(487-489)CTA>CTC	p.L163L	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Silent_p.L163L|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Silent_p.L131L|RDX_uc010rwe.1_Silent_p.L27L	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	163	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GTTCTTTTGTTAGTTTGTGTT	0.294													0	0	0	0.008291	0	9	34										G	110128893	T	G	110128893	2	3	126	1	0	0	0	0	0	0	0	1	13198	1741	61	5		5	RDX	11	110128893	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	5250989	110128893	24877623	325	37623										
BUD13	84811	broad.mit.edu	37	chr11	116633707	116633707	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggcctccttgggggagaagGatctggagaatcatgacggg	17	7	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:116633707G>A	uc001ppn.2	-	4	632	c.598C>T	c.(598-600)CCT>TCT	p.P200S	BUD13_uc001ppo.2_Missense_Mutation_p.P200S|BUD13_uc009yzc.2_Missense_Mutation_p.P200S	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	200	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGGGAGAAGGATCTGGAGAA	0.567													0	0	0	0.005524	0	38	115										A	116633707	G	A	116633707	3	1	126	1	0	0	0	0	1	0	0	0	1573	1174	41	1	1289	1	BUD13	11	116633707	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6504814	116633707	18372809	326	37624										
SIDT2	51092	broad.mit.edu	37	chr11	117052804	117052804	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agcagttcagcttcaataccAcagcagcacagccccaggta	8	14	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:117052804A>T	uc001pqh.1	+	4	540	c.499A>T	c.(499-501)ACA>TCA	p.T167S	SIDT2_uc010rxe.1_Missense_Mutation_p.T167S|SIDT2_uc001pqg.2_Missense_Mutation_p.T167S|SIDT2_uc001pqi.1_Missense_Mutation_p.T167S	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	167	Extracellular (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		CTTCAATACCACAGCAGCACA	0.597													0	0	0	0.00308	0	6	23										T	117052804	A	T	117052804	3	4	126	1	0	0	0	0	1	0	0	0	14303	159	6	5	513	5	SIDT2	11	117052804	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	419097	117052804	17953712	327	37625										
CCDC84	338657	broad.mit.edu	37	chr11	118881534	118881534	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaaaaggaggataaagtgatCaaggaggtaagttaaagtag	14	1	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:118881534C>T	uc001pul.2	+	4	500	c.444C>T	c.(442-444)ATC>ATT	p.I148I	CCDC84_uc010ryk.1_RNA|CCDC84_uc010ryl.1_RNA|CCDC84_uc010rym.1_RNA	NM_198489	NP_940891	Q86UT8	CCD84_HUMAN	coiled-coil domain containing 84	148	Potential.									ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		ATAAAGTGATCAAGGAGGTAA	0.234													0	0	0	0.00308	0	7	41										T	118881534	C	T	118881534	2	4	126	1	0	0	0	0	0	0	0	1	2858	816	29	1		1	CCDC84	11	118881534	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1828730	118881534	16124982	328	37626										
TECTA	7007	broad.mit.edu	37	chr11	121016422	121016422	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acagtccctcggagcatgcaGaacagcacctatggtctgtg	11	12	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:121016422G>T	uc010rzo.1	+	11	3702	c.3702G>T	c.(3700-3702)CAG>CAT	p.Q1234H		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1234	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGAGCATGCAGAACAGCACCT	0.527													1	0	1.15919e-05	0.008871	1.50913e-05	20	71										T	121016422	G	T	121016422	3	4	126	1	0	0	0	0	1	0	0	0	15744	933	33	3	3744	3	TECTA	11	121016422	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2134888	121016422	13990094	329	37627										
OR8B4	283162	broad.mit.edu	37	chr11	124294480	124294480	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagaaaaatagctgagtcatAcatcccacataagagatgat	7	7	1	4	rs142136468		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:124294480A>G	uc010sak.1	-	1	288	c.288T>C	c.(286-288)TGT>TGC	p.C96C		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GCTGAGTCATACATCCCACAT	0.403													0	0	0	0.006214	0	10	37										G	124294480	A	G	124294480	2	3	126	1	0	0	0	0	0	0	0	1	11229	389	14	5		5	OR8B4	11	124294480	Silent	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	3278058	124294480	10712036	330	37628										
OPCML	4978	broad.mit.edu	37	chr11	132812893	132812893	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggaaggtggcatctccgctgCgcacgggcactcctgtgggt	16	12	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr11:132812893C>A	uc001qgs.2	-	1	145	c.95G>T	c.(94-96)CGC>CTC	p.R32L	OPCML_uc001qgu.2_Missense_Mutation_p.R25L|OPCML_uc010sck.1_Missense_Mutation_p.R32L|OPCML_uc001qgt.2_Missense_Mutation_p.R32L|OPCML_uc010scl.1_5'UTR	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	32					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ATCTCCGCTGCGCACGGGCAC	0.647													1	0	1.3268e-25	0.01441	1.87154e-25	54	30										A	132812893	C	A	132812893	3	1	126	1	0	0	0	0	1	0	0	0	10874	768	27	4	970	4	OPCML	11	132812893	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8518413	132812893	2193623	331	37629										
ERC1	23085	broad.mit.edu	37	chr12	1599298	1599298	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaggtgaacgggacaatgcaGaactgcaggagtttgccaac	13	8	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:1599298G>A	uc001qjb.2	+	19	3494	c.3253G>A	c.(3253-3255)GAA>AAA	p.E1085K	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.E1057K|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_3'UTR|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	1085	Potential.|FIP-RBD.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GGACAATGCAGAACTGCAGGA	0.483													0	0	0	0.006999	0	38	78										A	1599298	G	A	1599298	3	1	126	1	0	0	0	0	1	0	0	0	5210	943	33	1	3323	1	ERC1	12	1599298	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		1599298	132252597	332	37630										
PRMT8	56341	broad.mit.edu	37	chr12	3649850	3649850	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgtccatcatgtgtccactCaacccagctgcccaggacgg	10	16	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:3649850C>G	uc001qmf.2	+	2	521	c.154C>G	c.(154-156)CAA>GAA	p.Q52E	PRMT8_uc009zed.2_Missense_Mutation_p.Q43E|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	52					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			TGTGTCCACTCAACCCAGCTG	0.602													0	0	0	0.01441	0	54	339										G	3649850	C	G	3649850	3	3	126	1	0	0	0	0	1	0	0	0	12542	827	29	1	160	1	PRMT8	12	3649850	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2050552	3649850	130202045	333	37631										
C12orf4	57102	broad.mit.edu	37	chr12	4599751	4599751	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgaagccatttccatcatGaaacctaaaatagaaaaaca	4	9	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:4599751G>A	uc001qms.2	-	13	1591	c.1503C>T	c.(1501-1503)TTC>TTT	p.F501F	C12orf4_uc001qmt.2_Silent_p.F501F	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	501											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		TTTCCATCATGAAACCTAAAA	0.388													0	0	0	0.00308	0	7	24										A	4599751	G	A	4599751	2	1	126	1	0	0	0	0	0	0	0	1	1685	1281	45	1		1	C12orf4	12	4599751	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	949901	4599751	129252144	334	37632										
VWF	7450	broad.mit.edu	37	chr12	6143929	6143929	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgaggtagtgggccatgccGatcgtggagcacgtggcatc	17	9	0	1	rs141982646	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:6143929G>A	uc001qnn.1	-	20	2860	c.2610C>T	c.(2608-2610)ATC>ATT	p.I870I	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	870	VWFD 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GGGCCATGCCGATCGTGGAGC	0.587													0	0	0	0.010504	0	19	74										A	6143929	G	A	6143929	2	1	126	1	0	0	0	0	0	0	0	1	17243	1048	37	1		1	VWF	12	6143929	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1544178	6143929	127707966	335	37633										
IFFO1	25900	broad.mit.edu	37	chr12	6664602	6664602	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agccggcgggcgtgcgagaaCgaccagatggtgccgggcat	18	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:6664602C>T	uc001qpd.1	-	1	628	c.594G>A	c.(592-594)TCG>TCA	p.S198S	IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Silent_p.S198S|IFFO1_uc001qpf.1_Silent_p.S198S|IFFO1_uc001qpc.1_Silent_p.S198S	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	198						intermediate filament					0						CGTGCGAGAACGACCAGATGG	0.612													0	0	0	0.014758	0	5	34										T	6664602	C	T	6664602	2	4	126	1	0	0	0	0	0	0	0	1	7510	523	19	2		2	IFFO1	12	6664602	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	520673	6664602	127187293	336	37634										
ACRBP	84519	broad.mit.edu	37	chr12	6749264	6749264	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atcctggaagctaaggaactCagtctggagccacccagaga	11	11	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:6749264C>G	uc001qpu.1	-	8	1435	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	LPAR5_uc010sff.1_5'Flank|ACRBP_uc001qpt.1_5'Flank|ACRBP_uc010sfg.1_Missense_Mutation_p.E430Q	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	463						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						CTAAGGAACTCAGTCTGGAGC	0.562													0	0	0	0.020292	0	12	65										G	6749264	C	G	6749264	3	3	126	1	0	0	0	0	1	0	0	0	170	835	29	1	256	1	ACRBP	12	6749264	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	84662	6749264	127102631	337	37635										
NANOG	79923	broad.mit.edu	37	chr12	7942264	7942264	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccttgctttgaagcatccgaCtgtaaagaatcttcacctat	6	11	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:7942264C>G	uc009zfy.1	+	1	270	c.54C>G	c.(52-54)GAC>GAG	p.D18E		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	18					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		AAGCATCCGACTGTAAAGAAT	0.453													0	0	0	0.016522	0	22	112										G	7942264	C	G	7942264	3	3	126	1	0	0	0	0	1	0	0	0	10150	564	20	4	56	4	NANOG	12	7942264	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1193000	7942264	125909631	338	37636										
A2ML1	144568	broad.mit.edu	37	chr12	8988223	8988223	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctacactgtggcagtggctGagggcaagacctttggtact	13	10	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:8988223G>A	uc001quz.3	+	6	702	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	46						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GGCAGTGGCTGAGGGCAAGAC	0.507													0	0	0	0.021523	0	23	74										A	8988223	G	A	8988223	3	1	126	1	0	0	0	0	1	0	0	0	5	1291	45	1	626	1	A2ML1	12	8988223	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1045959	8988223	124863672	339	37637										
MANSC1	54682	broad.mit.edu	37	chr12	12483751	12483751	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acttctgagaaagtgtgtctCtccatgagatatcggtgggc	12	8	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:12483751C>G	uc001rai.1	-	4	764	c.506G>C	c.(505-507)AGA>ACA	p.R169T	MANSC1_uc010shm.1_Missense_Mutation_p.R103T|MANSC1_uc001raj.1_Missense_Mutation_p.R135T|MANSC1_uc009zht.1_Missense_Mutation_p.R88T	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	169	Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		AAGTGTGTCTCTCCATGAGAT	0.448													0	0	0	0.00499	0	16	100										G	12483751	C	G	12483751	3	3	126	1	0	0	0	0	1	0	0	0	9224	913	32	1	793	1	MANSC1	12	12483751	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3495528	12483751	121368144	340	37638										
GSG1	83445	broad.mit.edu	37	chr12	13240941	13240941	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtagcaggaggaagctgatGaattgaagtccgatgtaggt	15	4	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:13240941G>A	uc001rbn.2	-	5	707	c.534C>T	c.(532-534)TTC>TTT	p.F178F	GSG1_uc001rbj.2_Silent_p.F142F|GSG1_uc001rbk.2_Missense_Mutation_p.H184Y|GSG1_uc001rbl.2_Intron|GSG1_uc001rbm.2_Intron|GSG1_uc001rbo.2_Missense_Mutation_p.H220Y|GSG1_uc001rbp.2_Silent_p.F155F|GSG1_uc001rbq.1_Missense_Mutation_p.H220Y	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	165	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GGAAGCTGATGAATTGAAGTC	0.512													0	0	0	0.004656	0	22	141										A	13240941	G	A	13240941	2	1	126	1	0	0	0	0	0	0	0	1	6820	1290	45	1		1	GSG1	12	13240941	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	757190	13240941	120610954	341	37639										
GRIN2B	2904	broad.mit.edu	37	chr12	13768066	13768066	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acctaagaaggcagaaggtgAgacagtcccattgctgcgtg	13	9	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:13768066A>T	uc001rbt.2	-	7	1815	c.1636T>A	c.(1636-1638)TCA>ACA	p.S546T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	546	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCAGAAGGTGAGACAGTCCCA	0.498													0	0	0	0.015359	0	32	76										T	13768066	A	T	13768066	3	4	126	1	0	0	0	0	1	0	0	0	6780	304	11	5	2846	5	GRIN2B	12	13768066	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	527125	13768066	120083829	342	37640										
ERP27	121506	broad.mit.edu	37	chr12	15073907	15073907	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgtggaggctgttgatctCaatgaaacggctcaatttgg	12	7	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:15073907C>A	uc001rco.2	-	4	430	c.409G>T	c.(409-411)GAG>TAG	p.E137*		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	137	Thioredoxin.					endoplasmic reticulum lumen				breast(1)	1						CTGTTGATCTCAATGAAACGG	0.438													1	0	0.000602214	0.014758	0.000762437	5	65										A	15073907	C	A	15073907	4	1	126	1	0	0	0	0	0	1	0	0	5241	835	29	3	428	3	ERP27	12	15073907	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1305841	15073907	118777988	343	37641										
SOX5	6660	broad.mit.edu	37	chr12	23893833	23893833	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgcttggccagctccatttGctgacgctgtttctcaatct	8	13	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:23893833G>T	uc001rfw.2	-	5	811	c.709C>A	c.(709-711)CAA>AAA	p.Q237K	SOX5_uc001rfx.2_Missense_Mutation_p.Q224K|SOX5_uc001rfy.2_Missense_Mutation_p.Q224K|SOX5_uc010siv.1_Missense_Mutation_p.Q224K|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.Q189K	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	237	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						AGCTCCATTTGCTGACGCTGT	0.498													1	0	0.00198382	0.001984	0.00250015	7	57										T	23893833	G	T	23893833	3	4	126	1	0	0	0	0	1	0	0	0	14954	1328	46	4	1636	4	SOX5	12	23893833	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	8819926	23893833	109958062	344	37642										
TM7SF3	51768	broad.mit.edu	37	chr12	27148173	27148173	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgggactcagatttaccttGagagcactggccttcacctg	10	11	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:27148173G>A	uc010sjl.1	-	5	925	c.687C>T	c.(685-687)CTC>CTT	p.L229L		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	229						integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					GATTTACCTTGAGAGCACTGG	0.468													0	0	0	0.008871	0	20	110										A	27148173	G	A	27148173	2	1	126	1	0	0	0	0	0	0	0	1	15972	1277	45	1		1	TM7SF3	12	27148173	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3254340	27148173	106703722	345	37643										
C12orf35	55196	broad.mit.edu	37	chr12	32136973	32136973	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctcaggaaatagatgcatcCagcaactatactccccaaga	6	13	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:32136973C>T	uc001rks.2	+	4	3498	c.3084C>T	c.(3082-3084)TCC>TCT	p.S1028S		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1028										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			TAGATGCATCCAGCAACTATA	0.433													0	0	0	0.009096	0	4	47										T	32136973	C	T	32136973	2	4	126	1	0	0	0	0	0	0	0	1	1682	581	21	2		2	C12orf35	12	32136973	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4988800	32136973	101714922	346	37644										
MLL2	8085	broad.mit.edu	37	chr12	49446362	49446362	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcacctagtggtttggcttCacattgcaggggccctggtt	12	11	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:49446362C>A	uc001rta.3	-	9	1243	c.1243G>T	c.(1243-1245)GAA>TAA	p.E415*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	415	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGTTTGGCTTCACATTGCAGG	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	0.00448238	0.004482	0.00562335	8	25										A	49446362	C	A	49446362	4	1	126	1	0	0	0	0	0	1	0	0	9621	835	29	3	15554	3	MLL2	12	49446362	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	17309389	49446362	84405533	347	37645										
MLL2	8085	broad.mit.edu	37	chr12	49446375	49446375	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttggcttcacattgcaggggCcctggttccttgggttgcat	13	10	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:49446375C>G	uc001rta.3	-	9	1230	c.1230G>C	c.(1228-1230)GGG>GGC	p.G410G		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	410	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATTGCAGGGGCCCTGGTTCCT	0.547			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.008291	0	10	25										G	49446375	C	G	49446375	2	3	126	1	0	0	0	0	0	0	0	1	9621	726	26	4		4	MLL2	12	49446375	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	13	49446375	84405520	348	37646										
ESPL1	9700	broad.mit.edu	37	chr12	53679861	53679861	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctggtggccactgtggccaAggagcctggccccatagcac	14	14	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:53679861A>T	uc001sck.2	+	18	3432	c.3341A>T	c.(3340-3342)AAG>ATG	p.K1114M	ESPL1_uc001scj.2_Missense_Mutation_p.K789M|ESPL1_uc010soe.1_Intron	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1114					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						ACTGTGGCCAAGGAGCCTGGC	0.602													0	0	0	0.005524	0	39	139										T	53679861	A	T	53679861	3	4	126	1	0	0	0	0	1	0	0	0	5253	72	3	5	3407	5	ESPL1	12	53679861	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	4233486	53679861	80172034	349	37647										
TARBP2	6895	broad.mit.edu	37	chr12	53899548	53899548	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccgcagttgctccctgggctCcctgggtgccctgggccctg	14	17	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:53899548C>G	uc001sdo.2	+	8	1345	c.857C>G	c.(856-858)TCC>TGC	p.S286C	TARBP2_uc001sdp.2_Missense_Mutation_p.S265C|TARBP2_uc001sdq.2_Missense_Mutation_p.S142C|TARBP2_uc001sdr.2_Missense_Mutation_p.S142C|TARBP2_uc001sds.2_Silent_p.L243L|TARBP2_uc001sdt.2_Missense_Mutation_p.S265C|TARBP2_uc001sdu.2_Missense_Mutation_p.S142C|TARBP2_uc001sdv.2_RNA	NM_134323	NP_599150	Q15633	TRBP2_HUMAN	TAR RNA binding protein 2 isoform a	286	Sufficient for interaction with DICER1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)	1						TCCCTGGGCTCCCTGGGTGCC	0.597													0	0	0	0.019004	0	34	123										G	53899548	C	G	53899548	3	3	126	1	0	0	0	0	1	0	0	0	15553	855	30	1	887	1	TARBP2	12	53899548	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	219687	53899548	79952347	350	37648										
OR6C76	390326	broad.mit.edu	37	chr12	55820354	55820354	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttctttatcttccttggctCaacggagtttttcctcctgg	7	11	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:55820354C>T	uc010spm.1	+	1	317	c.317C>T	c.(316-318)TCA>TTA	p.S106L		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCCTTGGCTCAACGGAGTTT	0.403													0	0	0	0.016723	0	14	47										T	55820354	C	T	55820354	3	4	126	1	0	0	0	0	1	0	0	0	11200	838	29	1	319	1	OR6C76	12	55820354	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1920806	55820354	78031541	351	37649										
DYRK2	8445	broad.mit.edu	37	chr12	68052281	68052281	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccccaggccaggctttgcggCacccctggctgaggaggcgg	16	15	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:68052281C>T	uc001str.3	+	3	1996	c.1594C>T	c.(1594-1596)CAC>TAC	p.H532Y	DYRK2_uc001sts.3_Missense_Mutation_p.H459Y	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	532	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		GGCTTTGCGGCACCCCTGGCT	0.547													0	0	0	0.004007	0	16	447										T	68052281	C	T	68052281	3	4	126	1	0	0	0	0	1	0	0	0	4856	710	25	2	1604	2	DYRK2	12	68052281	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	12231927	68052281	65799614	352	37650										
ZFC3H1	196441	broad.mit.edu	37	chr12	72014016	72014016	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggagttggtgcagagcaatCatgtttgtgtaaagtggaag	15	3	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:72014016C>G	uc001swo.2	-	25	5183	c.4824G>C	c.(4822-4824)ATG>ATC	p.M1608I		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1608	TPR 3.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCAGAGCAATCATGTTTGTGT	0.403													0	0	0	0.021523	0	23	364										G	72014016	C	G	72014016	3	3	126	1	0	0	0	0	1	0	0	0	17630	826	29	1	1189	1	ZFC3H1	12	72014016	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3961735	72014016	61837879	353	37651										
EEA1	8411	broad.mit.edu	37	chr12	93174109	93174109	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttcgtttagtttagtgatttCtttttcttgtctacatttaa	5	5	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:93174109C>G	uc001tck.2	-	24	3680	c.3415G>C	c.(3415-3417)GAA>CAA	p.E1139Q		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	1139	Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TTAGTGATTTCTTTTTCTTGT	0.308													0	0	0	0.001168	0	5	20										G	93174109	C	G	93174109	3	3	126	1	0	0	0	0	1	0	0	0	4921	922	32	1	844	1	EEA1	12	93174109	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	21160093	93174109	40677786	354	37652										
STAB2	55576	broad.mit.edu	37	chr12	104096936	104096936	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttgttcacagctctatgtaaAtgaggctccaataaactaca	6	9	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:104096936A>G	uc001tjw.2	+	35	3911	c.3725A>G	c.(3724-3726)AAT>AGT	p.N1242S		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1242	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CTCTATGTAAATGAGGCTCCA	0.373													0	0	0	0.008871	0	20	48										G	104096936	A	G	104096936	3	3	126	1	0	0	0	0	1	0	0	0	15237	101	4	5	3863	5	STAB2	12	104096936	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	10922827	104096936	29754959	355	37653										
C12orf45	121053	broad.mit.edu	37	chr12	105388290	105388290	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgagatgaatcagtcggattCaaaagaagtggacagttcag	12	5	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:105388290C>G	uc001tlb.2	+	4	407	c.374C>G	c.(373-375)TCA>TGA	p.S125*		NM_152318	NP_689531	Q8N5I9	CL045_HUMAN	hypothetical protein LOC121053	125											0						CAGTCGGATTCAAAAGAAGTG	0.294													0	0	0	0.012319	0	22	30										G	105388290	C	G	105388290	4	3	126	1	0	0	0	0	0	1	0	0	1691	838	29	1	388	1	C12orf45	12	105388290	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1291354	105388290	28463605	356	37654										
ANKRD13A	88455	broad.mit.edu	37	chr12	110456242	110456242	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atatcacattgctgggatttGaaaacatgagctggataaga	10	5	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:110456242G>C	uc001tpx.2	+	5	752	c.493G>C	c.(493-495)GAA>CAA	p.E165Q	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc009zvm.1_Missense_Mutation_p.E165Q|ANKRD13A_uc010sxw.1_Missense_Mutation_p.E165Q	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	165											0						GCTGGGATTTGAAAACATGAG	0.443													0	0	0	0.013537	0	11	69										C	110456242	G	C	110456242	3	2	126	1	0	0	0	0	1	0	0	0	641	1291	45	1	511	1	ANKRD13A	12	110456242	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5067952	110456242	23395653	357	37655										
RPH3A	22895	broad.mit.edu	37	chr12	113314469	113314469	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtggctccgagcgaccctggGaccactgccccaccccgaga	12	18	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:113314469G>A	uc010syl.1	+	13	1331	c.969G>A	c.(967-969)GGG>GGA	p.G323G	RPH3A_uc001ttz.2_Silent_p.G323G|RPH3A_uc001tty.2_Silent_p.G319G|RPH3A_uc009zwe.1_Silent_p.G319G|RPH3A_uc010sym.1_Silent_p.G274G|RPH3A_uc001tua.2_Silent_p.G83G	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	323	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GCGACCCTGGGACCACTGCCC	0.527													0	0	0	0.00308	0	7	17										A	113314469	G	A	113314469	2	1	126	1	0	0	0	0	0	0	0	1	13551	1161	41	1		1	RPH3A	12	113314469	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2858227	113314469	20537426	358	37656										
DDX54	79039	broad.mit.edu	37	chr12	113600964	113600964	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgctgtcaaagtccttgggcCggtaggggatgtagaattcc	14	9	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:113600964C>T	uc001tup.2	-	16	2082	c.2054G>A	c.(2053-2055)CGG>CAG	p.R685Q	DDX54_uc001tuq.3_Missense_Mutation_p.R685Q	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	685					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GTCCTTGGGCCGGTAGGGGAT	0.662													0	0	0	0.009718	0	42	20										T	113600964	C	T	113600964	3	4	126	1	0	0	0	0	1	0	0	0	4372	652	23	2	614	2	DDX54	12	113600964	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	286495	113600964	20250931	359	37657										
RPLP0	6175	broad.mit.edu	37	chr12	120635157	120635157	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgggaaggtgtaatccgtctCcacagacaaggccaggactc	12	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:120635157C>G	uc001txp.2	-	7	997	c.760G>C	c.(760-762)GAG>CAG	p.E254Q	GCN1L1_uc001txo.2_5'Flank|RPLP0_uc001txq.2_Missense_Mutation_p.E254Q|RPLP0_uc001txr.2_Missense_Mutation_p.E192Q	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	254					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAATCCGTCTCCACAGACAAG	0.507													0	0	0	0.014323	0	21	105										G	120635157	C	G	120635157	3	3	126	1	0	0	0	0	1	0	0	0	13604	864	30	1	201	1	RPLP0	12	120635157	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7034193	120635157	13216738	360	37658										
HPD	3242	broad.mit.edu	37	chr12	122286936	122286936	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggacaccatctcctgatcagGctggtttcccacaatgtggt	10	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:122286936G>T	uc001ubj.2	-	9	605	c.565C>A	c.(565-567)CCT>ACT	p.P189T	HPD_uc001ubk.2_Missense_Mutation_p.P150T	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	189					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TCCTGATCAGGCTGGTTTCCC	0.602													1	0	2.68362e-12	0.013537	3.66069e-12	12	89										T	122286936	G	T	122286936	3	4	126	1	0	0	0	0	1	0	0	0	7332	1203	42	4	640	4	HPD	12	122286936	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1651779	122286936	11564959	361	37659										
HIP1R	9026	broad.mit.edu	37	chr12	123343743	123343743	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggcatccttcagctgggccAggtgaggcacagctgagtgt	16	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:123343743A>T	uc001udj.1	+	22	2353	c.2294A>T	c.(2293-2295)CAG>CTG	p.Q765L	HIP1R_uc001udk.1_Missense_Mutation_p.Q30L	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	765					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CAGCTGGGCCAGGTGAGGCAC	0.652													0	0	0	0.014758	0	4	6										T	123343743	A	T	123343743	3	4	126	1	0	0	0	0	1	0	0	0	7115	202	7	5	2380	5	HIP1R	12	123343743	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1056807	123343743	10508152	362	37660										
PITPNM2	57605	broad.mit.edu	37	chr12	123494488	123494488	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tatgcgcacatgatggggaaGacctgcttcttgtactcctc	10	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:123494488G>A	uc001uej.1	-	5	691	c.552C>T	c.(550-552)GTC>GTT	p.V184V	PITPNM2_uc001uek.1_Silent_p.V184V|PITPNM2_uc009zxu.1_Silent_p.V184V	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	184					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGATGGGGAAGACCTGCTTCT	0.562													0	0	0	0.01441	0	55	190										A	123494488	G	A	123494488	2	1	126	1	0	0	0	0	0	0	0	1	11951	929	33	1		1	PITPNM2	12	123494488	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	150745	123494488	10357407	363	37661										
CHFR	55743	broad.mit.edu	37	chr12	133428240	133428241	+	Missense_Mutation	DNP	CC	CC	GT													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acgcgggtcctgctcgcgctCcgctctccggtcgggcatgg							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr12:133428240_133428241CC>GT	uc001ulf.2	-	12	1575_1576	c.1491_1492GG>AC	c.(1489-1494)GCGGAG>GCACAG	p.E498Q	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.E486Q|CHFR_uc010tbs.1_Missense_Mutation_p.E497Q|CHFR_uc001uld.2_Missense_Mutation_p.E457Q|CHFR_uc010tbt.1_Missense_Mutation_p.E406Q	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	498					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TGCTCGCGCTCCGCTCTCCGGT	0.644													0	0	0	0.004672	0	38	181										GT	133428241	CC	GT	133428240	3	3	126	1	0	0	0	0	1	0	0	0	3337	864	30	1	530	1	CHFR	12	133428240	Missense_Mutation	DNP	CC	TCGA-H4-A2HQ-01A-11D-A17V-08	9933752	133428240	423655	364	37662										
SACS	26278	broad.mit.edu	37	chr13	23907016	23907016	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tacctcttgatattgaggatGaaatctaatgaattccgcgg	9	7	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:23907016G>A	uc001uon.2	-	10	11588	c.10999C>T	c.(10999-11001)CAT>TAT	p.H3667Y	SACS_uc001uoo.2_Missense_Mutation_p.H3520Y|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3667					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TATTGAGGATGAAATCTAATG	0.383													0	0	0	0.001168	0	6	27										A	23907016	G	A	23907016	3	1	126	1	0	0	0	0	1	0	0	0	13804	1290	45	1	2744	1	SACS	13	23907016	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		23907016	91262862	365	37663										
SACS	26278	broad.mit.edu	37	chr13	23914840	23914840	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaagagatcctttagtacttCtatatcagggtcaaagagtt	8	6	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:23914840C>G	uc001uon.2	-	10	3764	c.3175G>C	c.(3175-3177)GAA>CAA	p.E1059Q	SACS_uc001uoo.2_Missense_Mutation_p.E912Q|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1059					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTTAGTACTTCTATATCAGGG	0.383													0	0	0	0.016522	0	25	102										G	23914840	C	G	23914840	3	3	126	1	0	0	0	0	1	0	0	0	13804	922	32	1	10568	1	SACS	13	23914840	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7824	23914840	91255038	366	37664										
FAM123A	219287	broad.mit.edu	37	chr13	25744587	25744587	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtcacagctgggacctgcctCttcctcttggtctgcaataa	9	13	4	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:25744587C>G	uc001uqb.2	-	1	1271	c.1171G>C	c.(1171-1173)GAG>CAG	p.E391Q	FAM123A_uc001uqa.2_Missense_Mutation_p.E272Q|FAM123A_uc001uqc.2_Missense_Mutation_p.E272Q	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	391										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGACCTGCCTCTTCCTCTTGG	0.532													0	0	0	0.012319	0	21	103										G	25744587	C	G	25744587	3	3	126	1	0	0	0	0	1	0	0	0	5422	922	32	1	848	1	FAM123A	13	25744587	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1829747	25744587	89425291	367	37665										
GPR12	2835	broad.mit.edu	37	chr13	27333290	27333290	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctatctgatgggcgtgcctCatcacaatcttacagatctg	9	11	5	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:27333290C>A	uc010aal.2	-	2	897	c.675G>T	c.(673-675)ATG>ATT	p.M225I	GPR12_uc010tdl.1_Missense_Mutation_p.M66I	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	225	Cytoplasmic (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		GGGCGTGCCTCATCACAATCT	0.567													1	0	1.06647e-15	0.017118	1.47173e-15	37	36										A	27333290	C	A	27333290	3	1	126	1	0	0	0	0	1	0	0	0	6635	826	29	3	333	3	GPR12	13	27333290	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1588703	27333290	87836588	368	37666										
NBEA	26960	broad.mit.edu	37	chr13	35926317	35926317	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagtgtgcccaatatgctgcTgatagaagagaggaagaaaa	12	6	0	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:35926317T>C	uc001uvb.2	+	38	6242	c.6036T>C	c.(6034-6036)GCT>GCC	p.A2012A	NBEA_uc010abi.2_Silent_p.A668A	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2012						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AATATGCTGCTGATAGAAGAG	0.328													0	0	0	0.014758	0	5	5										C	35926317	T	C	35926317	2	2	126	1	0	0	0	0	0	0	0	1	10187	1567	55	5		5	NBEA	13	35926317	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	8593027	35926317	79243561	369	37667										
DCLK1	9201	broad.mit.edu	37	chr13	36428670	36428670	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggcttcctgggctggtgggtGatgggcttggcgacttgcct	18	9	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:36428670G>A	uc001uvf.2	-	6	1234	c.1001C>T	c.(1000-1002)TCA>TTA	p.S334L	DCLK1_uc001uve.3_Missense_Mutation_p.S27L|DCLK1_uc010teh.1_Missense_Mutation_p.S27L|DCLK1_uc010abk.2_Missense_Mutation_p.S27L|DCLK1_uc001uvh.3_RNA	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	334	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GCTGGTGGGTGATGGGCTTGG	0.527													0	0	0	0.017118	0	33	75										A	36428670	G	A	36428670	3	1	126	1	0	0	0	0	1	0	0	0	4291	1294	45	1	1240	1	DCLK1	13	36428670	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	502353	36428670	78741208	370	37668										
SPERT	220082	broad.mit.edu	37	chr13	46287727	46287727	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgcgaggagaaccggatgctCagcaaggagaacaagatcct	13	10	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:46287727C>G	uc001van.1	+	3	647	c.567C>G	c.(565-567)CTC>CTG	p.L189L	SPERT_uc001vao.2_Silent_p.L153L	NM_152719	NP_689932	Q8NA61	SPERT_HUMAN	spermatid associated	189	Potential.					cytoplasmic membrane-bounded vesicle				central_nervous_system(1)|pancreas(1)	2		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		ACCGGATGCTCAGCAAGGAGA	0.617													0	0	0	0.020292	0	13	74										G	46287727	C	G	46287727	2	3	126	1	0	0	0	0	0	0	0	1	15038	813	29	1		1	SPERT	13	46287727	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	9859057	46287727	68882151	371	37669										
FNDC3A	22862	broad.mit.edu	37	chr13	49710722	49710722	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggaaaggtggtacacaagttGatacagaaattgaaggtaac	12	4	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:49710722G>A	uc001vcm.2	+	6	1050	c.745G>A	c.(745-747)GAT>AAT	p.D249N	FNDC3A_uc001vcl.1_Missense_Mutation_p.D249N|FNDC3A_uc001vcn.2_Missense_Mutation_p.D249N|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.D193N|FNDC3A_uc001vcq.2_Missense_Mutation_p.D193N	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	249						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TACACAAGTTGATACAGAAAT	0.353													0	0	0	0.001168	0	6	51										A	49710722	G	A	49710722	3	1	126	1	0	0	0	0	1	0	0	0	5969	1290	45	1	774	1	FNDC3A	13	49710722	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3422995	49710722	65459156	372	37670										
RNASEH2B	79621	broad.mit.edu	37	chr13	51528086	51528086	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tagaagcaaaagaagattacActaagtttaatactaaagat	6	4	0	4	rs150363383	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:51528086A>G	uc001vfa.3	+	10	1108	c.787A>G	c.(787-789)ACT>GCT	p.T263A	RNASEH2B_uc001vfb.3_Intron	NM_024570	NP_078846	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B isoform 1	263					RNA catabolic process	nucleus|ribonuclease H2 complex					0		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		AGAAGATTACACTAAGTTTAA	0.368													0	0	0	0.016723	0	12	8										G	51528086	A	G	51528086	3	3	126	1	0	0	0	0	1	0	0	0	13413	159	6	5	825	5	RNASEH2B	13	51528086	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1817364	51528086	63641792	373	37671										
LECT1	11061	broad.mit.edu	37	chr13	53286974	53286974	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacccagataagagaattttCttcatatttgactggcatga	7	8	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:53286974C>G	uc001vhf.2	-	5	610	c.499G>C	c.(499-501)GAA>CAA	p.E167Q	LECT1_uc001vhg.2_Missense_Mutation_p.E167Q|LECT1_uc001vhh.2_Missense_Mutation_p.E156Q	NM_007015	NP_008946	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1 isoform 1	167	BRICHOS.				cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		AGAGAATTTTCTTCATATTTG	0.403													0	0	0	0.01892	0	23	51										G	53286974	C	G	53286974	3	3	126	1	0	0	0	0	1	0	0	0	8712	922	32	1	517	1	LECT1	13	53286974	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1758888	53286974	61882904	374	37672										
C13orf34	79866	broad.mit.edu	37	chr13	73321010	73321010	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaaatcagtccagtgcttctGagaaagaattagcactgttg	9	7	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:73321010G>C	uc001viv.1	+	10	1362	c.1243G>C	c.(1243-1245)GAG>CAG	p.E415Q	C13orf34_uc010thq.1_Missense_Mutation_p.E190Q|C13orf34_uc010aen.1_Missense_Mutation_p.E490Q|C13orf34_uc010thr.1_Missense_Mutation_p.E345Q|C13orf34_uc001viw.1_Missense_Mutation_p.E364Q	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	415					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		CAGTGCTTCTGAGAAAGAATT	0.423													0	0	0	0.010729	0	12	36										C	73321010	G	C	73321010	3	2	126	1	0	0	0	0	1	0	0	0	1728	1291	45	1	1277	1	C13orf34	13	73321010	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	20034036	73321010	41848868	375	37673										
DIS3	22894	broad.mit.edu	37	chr13	73334745	73334745	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgattttcactttaactttAtcaaatacatggaacactgt	4	7	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:73334745A>G	uc001vix.3	-	20	3089	c.2715T>C	c.(2713-2715)GAT>GAC	p.D905D	DIS3_uc001viy.3_Silent_p.D875D|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	905					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CTTTAACTTTATCAAATACAT	0.328										Multiple Myeloma(4;0.011)			0	0	0	0.004482	0	9	36										G	73334745	A	G	73334745	2	3	126	1	0	0	0	0	0	0	0	1	4535	446	16	5		5	DIS3	13	73334745	Silent	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	13735	73334745	41835133	376	37674										
TBC1D4	9882	broad.mit.edu	37	chr13	75900527	75900527	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gacggtggggacgctggcggTgtccctggtggagaatcccc	18	11	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:75900527T>A	uc001vjl.1	-	10	2186	c.1839A>T	c.(1837-1839)ACA>ACT	p.T613T	TBC1D4_uc010aer.2_Silent_p.T613T|TBC1D4_uc010aes.2_Silent_p.T613T	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	613						cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		ACGCTGGCGGTGTCCCTGGTG	0.587													0	0	0	0.006214	0	8	64										A	75900527	T	A	75900527	2	1	126	1	0	0	0	0	0	0	0	1	15619	1683	59	5		5	TBC1D4	13	75900527	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	2565782	75900527	39269351	377	37675										
STK24	8428	broad.mit.edu	37	chr13	99114063	99114063	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtccgatggctgaagagctcCattctcgagattcttgggat	12	9	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:99114063C>G	uc001vnm.1	-	8	1289	c.1054G>C	c.(1054-1056)GGA>CGA	p.G352R	STK24_uc001vnn.1_Missense_Mutation_p.G340R|STK24_uc010tim.1_Missense_Mutation_p.G321R	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	352					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGAAGAGCTCCATTCTCGAGA	0.512													0	0	0	0.01441	0	42	208										G	99114063	C	G	99114063	3	3	126	1	0	0	0	0	1	0	0	0	15292	603	21	4	293	4	STK24	13	99114063	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	23213536	99114063	16055815	378	37676										
MYO16	23026	broad.mit.edu	37	chr13	109562401	109562401	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccagacttgtttcacaacctCttggccagagcaattttctc	6	13	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:109562401C>G	uc001vqt.1	+	16	1888	c.1762C>G	c.(1762-1764)CTT>GTT	p.L588V	MYO16_uc010agk.1_Missense_Mutation_p.L610V|MYO16_uc001vqu.1_Missense_Mutation_p.L388V|MYO16_uc010tjh.1_Missense_Mutation_p.L100V	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	588	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCACAACCTCTTGGCCAGAG	0.358													0	0	0	0.004007	0	17	80										G	109562401	C	G	109562401	3	3	126	1	0	0	0	0	1	0	0	0	10064	913	32	1	1820	1	MYO16	13	109562401	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	10448338	109562401	5607477	379	37677										
TUBGCP3	10426	broad.mit.edu	37	chr13	113208461	113208461	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catcccaactcagaaagcctGactgctgtgtctctcaaaga	7	13	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr13:113208461G>C	uc001vse.1	-	8	1063	c.876C>G	c.(874-876)GTC>GTG	p.V292V	TUBGCP3_uc010tjq.1_Silent_p.V282V|TUBGCP3_uc001vsf.2_Silent_p.V292V|TUBGCP3_uc001vsg.1_Silent_p.V292V	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	292					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CAGAAAGCCTGACTGCTGTGT	0.403													0	0	0	0.004007	0	16	75										C	113208461	G	C	113208461	2	2	126	1	0	0	0	0	0	0	0	1	16764	1277	45	1		1	TUBGCP3	13	113208461	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3646060	113208461	1961417	380	37678										
NEDD8	4738	broad.mit.edu	37	chr14	24687356	24687356	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacatctgcttgccactgtaGatgagcctctgctgttgtgg	11	11	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:24687356G>A	uc001wnn.2	-	3	235	c.132C>T	c.(130-132)ATC>ATT	p.I44I	CHMP4A_uc001wnj.2_5'Flank|MDP1_uc001wnk.1_5'Flank|CHMP4A_uc001wnm.1_5'Flank|MDP1_uc001wnl.1_5'Flank|NEDD8_uc001wno.2_RNA	NM_006156	NP_006147	Q15843	NEDD8_HUMAN	neural precursor cell expressed, developmentally	44		Interaction with UBE1C.			anatomical structure morphogenesis|protein neddylation|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin protein ligase binding				0				GBM - Glioblastoma multiforme(265;0.0186)		TGCCACTGTAGATGAGCCTCT	0.512													0	0	0	0.01441	0	47	83										A	24687356	G	A	24687356	2	1	126	1	0	0	0	0	0	0	0	1	10312	932	33	1		1	NEDD8	14	24687356	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		24687356	82662184	381	37679										
CTSG	1511	broad.mit.edu	37	chr14	25045381	25045381	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggatggtcactcacctgcctCagccccagtgggtaggagaa	13	12	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:25045381C>A	uc001wpq.2	-	1	86	c.49G>T	c.(49-51)GAG>TAG	p.E17*		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	17					immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TCACCTGCCTCAGCCCCAGTG	0.438													1	0	0.00116845	0.001168	0.00147706	5	10										A	25045381	C	A	25045381	4	1	126	1	0	0	0	0	0	1	0	0	4035	835	29	3	738	3	CTSG	14	25045381	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	358025	25045381	82304159	382	37680										
C14orf106	55320	broad.mit.edu	37	chr14	45679581	45679581	+	Splice_Site	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tatcatatgcatgaatatttAcctatttatagaacctagca	4	7	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:45679581A>C	uc001wwf.2	-	14	3611	c.3152_splice	c.e14+1	p.R1051_splice		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106						cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						ATGAATATTTACCTATTTATA	0.378													0	0	0	0.008291	0	9	27										C	45679581	A	C	45679581	5	2	126	1	0	0	0	0	0	0	1	0	1738	405	14	5	260	5	C14orf106	14	45679581	Splice_Site	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	20634200	45679581	61669959	383	37681										
CDKL1	8814	broad.mit.edu	37	chr14	50845115	50845115	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	taggtaccagcagccgtcttGaaggggctgggccgtgatag	16	9	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:50845115G>C	uc010anu.1	-	9	1134	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	CDKL1_uc001wxz.2_Intron	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					cagccgtcttgaaggggctgg	0													0	0	0	0.006214	0	10	31										C	50845115	G	C	50845115	3	2	126	1	0	0	0	0	1	0	0	0	3153	1305	45	1		1	CDKL1	14	50845115	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5165534	50845115	56504425	384	37682										
PTGER2	5732	broad.mit.edu	37	chr14	52781368	52781368	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agctccgtcatgttctcggcCggggtgctggggaacctcat	14	12	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:52781368C>T	uc001wzr.2	+	1	353	c.102C>T	c.(100-102)GCC>GCT	p.A34A		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	34	Helical; Name=1; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	TGTTCTCGGCCGGGGTGCTGG	0.682													0	0	0	0.010504	0	20	19										T	52781368	C	T	52781368	2	4	126	1	0	0	0	0	0	0	0	1	12743	639	23	2		2	PTGER2	14	52781368	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1936253	52781368	54568172	385	37683										
RTN1	6252	broad.mit.edu	37	chr14	60193667	60193667	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	attgagaaacagcagtggggGcggggcgccaggacctagag	18	8	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:60193667G>C	uc001xen.1	-	3	1944	c.1735C>G	c.(1735-1737)CCC>GCC	p.P579A	RTN1_uc001xem.1_Missense_Mutation_p.P159A	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	579					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		AGCAGTGGGGGCGGGGCGCCA	0.582													0	0	0	0.001984	0	6	22										C	60193667	G	C	60193667	3	2	126	1	0	0	0	0	1	0	0	0	13725	1203	42	4	688	4	RTN1	14	60193667	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7412299	60193667	47155873	386	37684										
PPM1A	5494	broad.mit.edu	37	chr14	60749714	60749714	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	accttctgtggaaaatgtaaAgaatggaatcagaacaggtt	10	5	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:60749714A>G	uc010apn.2	+	3	695	c.293A>G	c.(292-294)AAG>AGG	p.K98R	PPM1A_uc001xew.3_Missense_Mutation_p.K171R|PPM1A_uc001xex.3_Missense_Mutation_p.K98R|PPM1A_uc001xey.3_Missense_Mutation_p.K98R	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	98					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		GAAAATGTAAAGAATGGAATC	0.418													0	0	0	0.004656	0	27	68										G	60749714	A	G	60749714	3	3	126	1	0	0	0	0	1	0	0	0	12335	72	3	5	518	5	PPM1A	14	60749714	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	556047	60749714	46599826	387	37685										
SYNE2	23224	broad.mit.edu	37	chr14	64497985	64497985	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggaaagtttactctgccaggCagagagaagcaggccacttc	12	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:64497985C>G	uc001xgm.2	+	45	7361	c.7131C>G	c.(7129-7131)GGC>GGG	p.G2377G	SYNE2_uc001xgl.2_Silent_p.G2377G	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2377	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTCTGCCAGGCAGAGAGAAGC	0.453													0	0	0	0.021523	0	25	76										G	64497985	C	G	64497985	2	3	126	1	0	0	0	0	0	0	0	1	15443	697	25	4		4	SYNE2	14	64497985	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3748271	64497985	42851555	388	37686										
PTPN21	11099	broad.mit.edu	37	chr14	88936060	88936060	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgtggccagtacctaaagctCttctcccttccaccctcctg	6	18	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:88936060C>A	uc001xwv.3	-	17	3349	c.3018G>T	c.(3016-3018)AAG>AAT	p.K1006N	PTPN21_uc010twc.1_Missense_Mutation_p.K802N	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1006	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						ACCTAAAGCTCTTCTCCCTTC	0.502													1	0	9.70103e-10	0.008291	1.30609e-09	9	20										A	88936060	C	A	88936060	3	1	126	1	0	0	0	0	1	0	0	0	12786	912	32	3	518	3	PTPN21	14	88936060	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	24438075	88936060	18413480	389	37687										
EML5	161436	broad.mit.edu	37	chr14	89109329	89109329	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaacattattcctacagtctCtgcctcgataaccaaaaatg	5	11	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:89109329C>G	uc001xxg.2	-	31	4331	c.4145G>C	c.(4144-4146)AGA>ACA	p.R1382T	EML5_uc001xxf.2_Missense_Mutation_p.R169T|EML5_uc001xxh.1_Missense_Mutation_p.R513T	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1374						cytoplasm|microtubule				ovary(3)	3						CCTACAGTCTCTGCCTCGATA	0.338													0	0	0	0.00499	0	16	45										G	89109329	C	G	89109329	3	3	126	1	0	0	0	0	1	0	0	0	5100	913	32	1	1844	1	EML5	14	89109329	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	173269	89109329	18240211	390	37688										
BTBD7	55727	broad.mit.edu	37	chr14	93717986	93717986	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgtttgttccaccatcatctCatctagcactgactgaaata	5	12	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:93717986C>T	uc001ybo.2	-	8	2091	c.1765G>A	c.(1765-1767)GAG>AAG	p.E589K	BTBD7_uc010aur.2_Missense_Mutation_p.E114K|BTBD7_uc010two.1_Missense_Mutation_p.E409K|BTBD7_uc001ybp.2_Missense_Mutation_p.E238K	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	589										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACCATCATCTCATCTAGCACT	0.403													0	0	0	0.01441	0	49	37										T	93717986	C	T	93717986	3	4	126	1	0	0	0	0	1	0	0	0	1546	835	29	1	1649	1	BTBD7	14	93717986	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4608657	93717986	13631554	391	37689										
DYNC1H1	1778	broad.mit.edu	37	chr14	102510695	102510695	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccatttatggcgggcgcgtgGacaacgagtttgaccagcgt	14	10	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr14:102510695G>C	uc001yks.2	+	71	12933	c.12769G>C	c.(12769-12771)GAC>CAC	p.D4257H		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4257					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CGGGCGCGTGGACAACGAGTT	0.557													0	0	0	0.013537	0	10	18										C	102510695	G	C	102510695	3	2	126	1	0	0	0	0	1	0	0	0	4841	1174	41	1	13051	1	DYNC1H1	14	102510695	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	8792709	102510695	4838845	392	37690										
EIF2AK4	440275	broad.mit.edu	37	chr15	40301819	40301819	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttctccatatcccaggaaaGaaattacagtatttatttga	5	7	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:40301819G>C	uc001zkm.1	+	26	3631	c.3581G>C	c.(3580-3582)AGA>ACA	p.R1194T	EIF2AK4_uc010bbj.1_Missense_Mutation_p.R895T|EIF2AK4_uc001zkn.1_Missense_Mutation_p.R294T|EIF2AK4_uc001zko.1_Missense_Mutation_p.R132T|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1194	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCCCAGGAAAGAAATTACAGT	0.333													0	0	0	0.004482	0	9	28										C	40301819	G	C	40301819	3	2	126	1	0	0	0	0	1	0	0	0	4999	942	33	1	3683	1	EIF2AK4	15	40301819	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		40301819	62229573	393	37691										
ITPKA	3706	broad.mit.edu	37	chr15	41794660	41794660	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaagccgagagcaggtgcttCgcgtctttgaagagtttgtg	15	7	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:41794660C>T	uc001znz.2	+	5	1080	c.1069C>T	c.(1069-1071)CGC>TGC	p.R357C		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	357					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCAGGTGCTTCGCGTCTTTGA	0.622													0	0	0	0.017118	0	33	67										T	41794660	C	T	41794660	3	4	126	1	0	0	0	0	1	0	0	0	7917	884	31	1	1087	1	ITPKA	15	41794660	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1492841	41794660	60736732	394	37692										
SLC24A5	283652	broad.mit.edu	37	chr15	48434351	48434351	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcctgcagaagtaaacagcAgaggactaacttacataacc	7	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:48434351A>G	uc001zwe.2	+	9	1379	c.1306A>G	c.(1306-1308)AGA>GGA	p.R436G	SLC24A5_uc010bel.2_Missense_Mutation_p.R376G|MYEF2_uc001zwg.3_3'UTR|MYEF2_uc001zwh.3_3'UTR|MYEF2_uc001zwi.3_3'UTR|MYEF2_uc001zwj.3_3'UTR|SLC24A5_uc001zwk.2_Missense_Mutation_p.R67G	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	436	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		AGTAAACAGCAGAGGACTAAC	0.363													0	0	0	0.003163	0	16	37										G	48434351	A	G	48434351	3	3	126	1	0	0	0	0	1	0	0	0	14469	180	7	5	1340	5	SLC24A5	15	48434351	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	6639691	48434351	54097041	395	37693										
MYEF2	50804	broad.mit.edu	37	chr15	48444460	48444460	+	Frame_Shift_Del	DEL	C	C	-													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttctattcattcctccaaaaCctggaccatccattcccata							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:48444460delC	uc001zwi.3	-	11	1233	c.1109delG	c.(1108-1110)GGTfs	p.G370fs	MYEF2_uc001zwg.3_5'Flank|MYEF2_uc001zwh.3_5'Flank|MYEF2_uc001zwj.3_Frame_Shift_Del_p.G370fs	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	370	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TCCTCCAAAACCTGGACCATC	0.289																		9	33	---	---								-	48444460	C	-	48444460	7	5	126	1	0	1	0	1	0	0	0	0	10024	507	18	0	721	0	MYEF2	15	48444460	Frame_Shift_Del	DEL	C	TCGA-H4-A2HQ-01A-11D-A17V-08	10109	48444460	54086932	396	37694										
USP8	9101	broad.mit.edu	37	chr15	50784944	50784944	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctcaaggctttctgcttctCagattcggaacctcaatcct	6	13	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:50784944C>G	uc001zym.3	+	16	2781	c.2281C>G	c.(2281-2283)CAG>GAG	p.Q761E	USP8_uc001zyl.3_Missense_Mutation_p.Q761E|USP8_uc001zyn.3_Missense_Mutation_p.Q761E|USP8_uc010ufh.1_Missense_Mutation_p.Q655E|uc001zyo.1_RNA|USP8_uc001zyp.3_5'Flank	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	761					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TTCTGCTTCTCAGATTCGGAA	0.388													0	0	0	0.012319	0	19	65										G	50784944	C	G	50784944	3	3	126	1	0	0	0	0	1	0	0	0	17086	827	29	1	2335	1	USP8	15	50784944	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2340484	50784944	51746448	397	37695										
WDR72	256764	broad.mit.edu	37	chr15	54008834	54008834	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtgtgcctgtaaggaagtgtAgccttctccatgcactgtcc	11	11	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:54008834A>T	uc002acj.2	-	4	351	c.309T>A	c.(307-309)GCT>GCA	p.A103A	WDR72_uc010bfi.1_Silent_p.A103A	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	103										lung(1)|skin(1)	2				all cancers(107;0.0511)		AAGGAAGTGTAGCCTTCTCCA	0.428													0	0	0	0.008291	0	9	25										T	54008834	A	T	54008834	2	4	126	1	0	0	0	0	0	0	0	1	17319	407	15	5		5	WDR72	15	54008834	Silent	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	3223890	54008834	48522558	398	37696										
GCOM1	145781	broad.mit.edu	37	chr15	57921940	57921940	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttggaaaacagcaacattaAggatcaaatcagaaatctgc	7	7	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:57921940A>T	uc002aei.2	+	6	685	c.566A>T	c.(565-567)AAG>ATG	p.K189M	GCOM1_uc002aej.2_Missense_Mutation_p.K189M|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Missense_Mutation_p.K189M|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Missense_Mutation_p.K189M|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	189	Potential.				intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AGCAACATTAAGGATCAAATC	0.458													0	0	0	0.016723	0	13	34										T	57921940	A	T	57921940	3	4	126	1	0	0	0	0	1	0	0	0	6304	72	3	5	588	5	GCOM1	15	57921940	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	3913106	57921940	44609452	399	37697										
VPS13C	54832	broad.mit.edu	37	chr15	62219320	62219320	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttttccctctcttttctctGagaaaagggcaagcgagcac	8	11	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:62219320G>C	uc002agz.2	-	52	6560	c.6486C>G	c.(6484-6486)CTC>CTG	p.L2162L	VPS13C_uc002aha.2_Silent_p.L2119L|VPS13C_uc002ahb.1_Silent_p.L2162L|VPS13C_uc002ahc.1_Silent_p.L2119L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2162					protein localization					ovary(2)	2						TCTTTTCTCTGAGAAAAGGGC	0.393													0	0	0	0.017118	0	34	71										C	62219320	G	C	62219320	2	2	126	1	0	0	0	0	0	0	0	1	17188	1277	45	1		1	VPS13C	15	62219320	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4297380	62219320	40312072	400	37698										
MPI	4351	broad.mit.edu	37	chr15	75183880	75183880	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttcctcttcaaagtgctctCagttgaaacacccctgtcca	5	15	3	1	rs104894494		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr15:75183880C>T	uc002azc.1	+	3	310	c.305C>T	c.(304-306)TCA>TTA	p.S102L	MPI_uc010ulv.1_Missense_Mutation_p.S102L|MPI_uc010ulw.1_Missense_Mutation_p.S52L|MPI_uc002azd.1_Missense_Mutation_p.S102L|MPI_uc010ulx.1_Missense_Mutation_p.S52L|MPI_uc002aze.1_Missense_Mutation_p.S102L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	102			S -> L (in CDG1B).		dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						AAAGTGCTCTCAGTTGAAACA	0.532													0	0	0	0.01441	0	44	107										T	75183880	C	T	75183880	3	4	126	1	0	0	0	0	1	0	0	0	9729	838	29	1	315	1	MPI	15	75183880	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	12964560	75183880	27347512	401	37699										
WFIKKN1	117166	broad.mit.edu	37	chr16	683267	683267	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtggtccagcgagagccggCcagggacgcagcccccagca	15	15	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:683267C>T	uc002cht.1	+	2	1099	c.857C>T	c.(856-858)GCC>GTC	p.A286V	WFIKKN1_uc002chs.1_3'UTR	NM_053284	NP_444514	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz	286						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity				0		Hepatocellular(780;0.00335)				CGAGAGCCGGCCAGGGACGCA	0.716													0	0	0	0.009096	0	4	10										T	683267	C	T	683267	3	4	126	1	0	0	0	0	1	0	0	0	17355	739	26	2	863	2	WFIKKN1	16	683267	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		683267	89671486	402	37700										
NUBP2	10101	broad.mit.edu	37	chr16	1836612	1836612	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggggcgttgggaaaagcaccAtctccacggagctggccctg	15	12	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:1836612A>G	uc002cmw.3	+	2	180	c.91A>G	c.(91-93)ATC>GTC	p.I31V	NUBP2_uc002cmx.3_5'UTR|NUBP2_uc010brx.2_5'UTR	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	31						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0						GAAAAGCACCATCTCCACGGA	0.662													0	0	0	0.016723	0	13	85										G	1836612	A	G	1836612	3	3	126	1	0	0	0	0	1	0	0	0	10716	217	8	5	97	5	NUBP2	16	1836612	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1153345	1836612	88518141	403	37701										
TSC2	7249	broad.mit.edu	37	chr16	2110796	2110796	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgctgaacatcatcgaacgGctccttcagcagctccaggt	9	14	2	1	rs45517149		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:2110796G>A	uc002con.2	+	11	1207	c.1101G>A	c.(1099-1101)CGG>CGA	p.R367R	TSC2_uc010bsd.2_Silent_p.R367R|TSC2_uc002coo.2_Silent_p.R367R|TSC2_uc010uvv.1_Silent_p.R330R|TSC2_uc010uvw.1_Silent_p.R318R|TSC2_uc002cop.2_Silent_p.R167R	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	367	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				TCATCGAACGGCTCCTTCAGC	0.602			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.014323	0	24	35										A	2110796	G	A	2110796	2	1	126	1	0	0	0	0	0	0	0	1	16603	1190	42	2		2	TSC2	16	2110796	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	274184	2110796	88243957	404	37702										
PRSS21	10942	broad.mit.edu	37	chr16	2868796	2868796	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acttcgtatcgaatatctatCtgagccctcgctacctgggg	9	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:2868796C>T	uc002crt.2	+	4	482	c.376C>T	c.(376-378)CTG>TTG	p.L126L	PRSS21_uc002crs.2_Silent_p.L124L|PRSS21_uc002crr.2_Silent_p.L126L	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	126	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						GAATATCTATCTGAGCCCTCG	0.537													0	0	0	0.005443	0	26	116										T	2868796	C	T	2868796	2	4	126	1	0	0	0	0	0	0	0	1	12618	912	32	1		1	PRSS21	16	2868796	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	758000	2868796	87485957	405	37703										
BTBD12	84464	broad.mit.edu	37	chr16	3641148	3641148	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cttggatttcaacaaagtctCcgcttcctcctcttcatctg	5	14	5	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:3641148C>A	uc002cvp.2	-	12	3118	c.2491G>T	c.(2491-2493)GAG>TAG	p.E831*		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	831	Potential.|Interaction with PLK1 and TERF2-TERF2IP.|Glu-rich.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						AACAAAGTCTCCGCTTCCTCC	0.453								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				1	0	2.94884e-30	0.01441	4.17374e-30	69	101										A	3641148	C	A	3641148	4	1	126	1	0	0	0	0	0	1	0	0	1540	864	30	3	3029	3	BTBD12	16	3641148	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	772352	3641148	86713605	406	37704										
VASN	114990	broad.mit.edu	37	chr16	4431070	4431070	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tacgtctttgagaacggcatCaccatgctcgacgcaggcag	11	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:4431070C>T	uc002cwj.1	+	2	347	c.192C>T	c.(190-192)ATC>ATT	p.I64I	CORO7_uc002cwe.2_Intron|CORO7_uc002cwf.2_Intron|CORO7_uc002cwg.3_Intron|CORO7_uc002cwh.3_Intron|CORO7_uc010uxh.1_Intron|CORO7_uc010uxi.1_Intron|CORO7_uc002cwi.1_Intron|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_Intron	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	slit-like 2 precursor	64	Extracellular (Potential).|LRR 1.					extracellular region|integral to membrane					0						AGAACGGCATCACCATGCTCG	0.672													0	0	0	0.00308	0	7	13										T	4431070	C	T	4431070	2	4	126	1	0	0	0	0	0	0	0	1	17124	816	29	1		1	VASN	16	4431070	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	789922	4431070	85923683	407	37705										
NAGPA	51172	broad.mit.edu	37	chr16	5075523	5075523	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gccccctggctgctccttctCtgcggccagaggctccccgt	11	19	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:5075523C>T	uc002cyg.2	-	10	1525	c.1504G>A	c.(1504-1506)GAG>AAG	p.E502K	NAGPA_uc010buc.2_Missense_Mutation_p.E199K|NAGPA_uc002cyf.2_Missense_Mutation_p.E220K|NAGPA_uc002cyh.2_RNA|NAGPA_uc002cyi.2_3'UTR	NM_016256	NP_057340	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester	502	Cytoplasmic (Potential).				carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity				0					N-Acetyl-D-glucosamine(DB00141)	TGCTCCTTCTCTGCGGCCAGA	0.647													0	0	0	0.01441	0	58	238										T	5075523	C	T	5075523	3	4	126	1	0	0	0	0	1	0	0	0	10144	922	32	1	47	1	NAGPA	16	5075523	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	644453	5075523	85279230	408	37706										
C16orf75	116028	broad.mit.edu	37	chr16	11444614	11444614	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgaaagtatgtgggaactGgaggtagaagatttacacag	13	4	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:11444614G>A	uc002daw.1	+	2	429	c.411G>A	c.(409-411)CTG>CTA	p.L137L	C16orf75_uc002daq.1_RNA	NM_152308	NP_689521	Q96E14	RMI2_HUMAN	RecQ-mediated genome instability protein 2	137					DNA replication	nucleus	DNA binding				0						TGTGGGAACTGGAGGTAGAAG	0.438			T	CIITA	PMBL|Hodgkin Lymphona|								0	0	0	0.010504	0	19	108										A	11444614	G	A	11444614	2	1	126	1	0	0	0	0	0	0	0	1	1834	1335	47	2		2	C16orf75	16	11444614	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	6369091	11444614	78910139	409	37707										
ITPRIPL2	162073	broad.mit.edu	37	chr16	19126901	19126901	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agctccaggtgcctgctaccTcaagtgcctgcagttgctta	10	13	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:19126901T>A	uc002dfu.3	+	1	1648	c.1118T>A	c.(1117-1119)CTC>CAC	p.L373H	ITPRIPL2_uc002dft.2_Missense_Mutation_p.L69H	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	373	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GCCTGCTACCTCAAGTGCCTG	0.647													0	0	0	0.013726	0	34	146										A	19126901	T	A	19126901	3	1	126	1	0	0	0	0	1	0	0	0	7925	1551	54	5	1120	5	ITPRIPL2	16	19126901	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	7682287	19126901	71227852	410	37708										
DNAH3	55567	broad.mit.edu	37	chr16	21073952	21073952	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cggctgcactcggagagggtCctttgtctcggacaagattt	13	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:21073952C>T	uc010vbe.1	-	25	3571	c.3571G>A	c.(3571-3573)GAC>AAC	p.D1191N		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1191	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CGGAGAGGGTCCTTTGTCTCG	0.448													0	0	0	0.004007	0	17	47										T	21073952	C	T	21073952	3	4	126	1	0	0	0	0	1	0	0	0	4603	855	30	1	8930	1	DNAH3	16	21073952	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1947051	21073952	69280801	411	37709										
JMJD5	79831	broad.mit.edu	37	chr16	27221612	27221612	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagcgagccactgagctcttCtacgagggcaggagggacga	15	11	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:27221612C>T	uc002doh.2	+	2	350	c.168C>T	c.(166-168)TTC>TTT	p.F56F	JMJD5_uc010bxv.2_Silent_p.F56F|JMJD5_uc010vcn.1_Silent_p.F94F|JMJD5_uc010bxw.2_Silent_p.F56F	NM_024773	NP_079049	Q8N371	KDM8_HUMAN	jumonji domain containing 5 isoform 2	56					G2/M transition of mitotic cell cycle|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|histone demethylase activity (H3-K36 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(2)|upper_aerodigestive_tract(1)	3						CTGAGCTCTTCTACGAGGGCA	0.587													0	0	0	0.013537	0	12	55										T	27221612	C	T	27221612	2	4	126	1	0	0	0	0	0	0	0	1	7952	912	32	1		1	JMJD5	16	27221612	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6147660	27221612	63133141	412	37710										
SRCAP	10847	broad.mit.edu	37	chr16	30750254	30750254	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggatggcaactccgaaagtCggacacagccacccccacac	10	16	0	0	rs141497857		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:30750254C>T	uc002dze.1	+	34	9278	c.8893C>T	c.(8893-8895)CGG>TGG	p.R2965W	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2760W	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2965	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTCCGAAAGTCGGACACAGCC	0.572													0	0	0	0.014323	0	22	111										T	30750254	C	T	30750254	3	4	126	1	0	0	0	0	1	0	0	0	15134	875	31	1	9019	1	SRCAP	16	30750254	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3528642	30750254	59604499	413	37711										
RNF40	9810	broad.mit.edu	37	chr16	30780185	30780185	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagctgcggagccgcatccgGgaattggaggagagggatcg	19	8	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:30780185G>A	uc002dzq.2	+	15	2247	c.2124G>A	c.(2122-2124)CGG>CGA	p.R708R	RNF40_uc010caa.2_Silent_p.R708R|RNF40_uc010cab.2_Silent_p.R608R|RNF40_uc010vfa.1_Silent_p.R40R|RNF40_uc002dzr.2_Silent_p.R708R|RNF40_uc010vfb.1_Silent_p.R400R|RNF40_uc010vfc.1_Silent_p.R40R	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	708	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GCCGCATCCGGGAATTGGAGG	0.562													0	0	0	0.01441	0	58	147										A	30780185	G	A	30780185	2	1	126	1	0	0	0	0	0	0	0	1	13493	1219	43	2		2	RNF40	16	30780185	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	29931	30780185	59574568	414	37712										
C16orf78	123970	broad.mit.edu	37	chr16	49433094	49433094	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccttgctcaagttgtgcaagGatgcaggaatgaatgtggat	13	6	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:49433094G>A	uc002efr.2	+	5	746	c.703G>A	c.(703-705)GAT>AAT	p.D235N		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	235										central_nervous_system(1)	1						GTTGTGCAAGGATGCAGGAAT	0.478													0	0	0	0.016522	0	23	101										A	49433094	G	A	49433094	3	1	126	1	0	0	0	0	1	0	0	0	1835	1174	41	1	721	1	C16orf78	16	49433094	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	18652909	49433094	40921659	415	37713										
GNAO1	2775	broad.mit.edu	37	chr16	56362664	56362664	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggaatccaagagtgcttcaAccggtcccgggagtatcagc	12	11	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:56362664A>G	uc002eit.3	+	4	1322	c.425A>G	c.(424-426)AAC>AGC	p.N142S	GNAO1_uc002eiu.3_Missense_Mutation_p.N142S	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	142					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				GAGTGCTTCAACCGGTCCCGG	0.602													0	0	0	0.005443	0	27	74										G	56362664	A	G	56362664	3	3	126	1	0	0	0	0	1	0	0	0	6508	43	2	5	439	5	GNAO1	16	56362664	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	6929570	56362664	33992089	416	37714										
AMFR	267	broad.mit.edu	37	chr16	56423172	56423172	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgctacaggaaccaaattctCatccaagttctctccttgat	5	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:56423172C>T	uc002eiy.2	-	9	1406	c.1201G>A	c.(1201-1203)GAG>AAG	p.E401K	AMFR_uc002eix.2_Intron	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor	401					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2						ACCAAATTCTCATCCAAGTTC	0.448													0	0	0	0.00499	0	16	113										T	56423172	C	T	56423172	3	4	126	1	0	0	0	0	1	0	0	0	571	835	29	1	754	1	AMFR	16	56423172	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	60508	56423172	33931581	417	37715										
GPR97	222487	broad.mit.edu	37	chr16	57712121	57712121	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggacgaggacaagccccctGacagagtgcgacttcccaag	12	13	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:57712121G>C	uc002emh.2	+	4	488	c.385G>C	c.(385-387)GAC>CAC	p.D129H	GPR97_uc010cdc.2_Missense_Mutation_p.D129H|GPR97_uc010vhv.1_Missense_Mutation_p.D9H|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_5'Flank	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	129	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CAAGCCCCCTGACAGAGTGCG	0.587													0	0	0	0.00632	0	26	153										C	57712121	G	C	57712121	3	2	126	1	0	0	0	0	1	0	0	0	6720	1290	45	1	399	1	GPR97	16	57712121	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1288949	57712121	32642632	418	37716										
CNGB1	1258	broad.mit.edu	37	chr16	57935315	57935315	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgaagcctcttcagcatgtCaaagatcatctgccggtcac	9	13	6	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:57935315C>T	uc002emt.2	-	29	2982	c.2917G>A	c.(2917-2919)GAC>AAC	p.D973N	CNGB1_uc010cdh.2_Missense_Mutation_p.D967N	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	973	Helical; Name=H6; (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						TTCAGCATGTCAAAGATCATC	0.572													0	0	0	0.01441	0	67	197										T	57935315	C	T	57935315	3	4	126	1	0	0	0	0	1	0	0	0	3600	826	29	1	858	1	CNGB1	16	57935315	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	223194	57935315	32419438	419	37717										
GFOD2	81577	broad.mit.edu	37	chr16	67709852	67709852	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aggcaggaagcgcagcacgtTccctaccaggctcatgagct	12	13	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:67709852T>A	uc002eub.2	-	3	659	c.364A>T	c.(364-366)AAC>TAC	p.N122Y	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.N17Y	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	122						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		CGCAGCACGTTCCCTACCAGG	0.572													0	0	0	0.013537	0	11	86										A	67709852	T	A	67709852	3	1	126	1	0	0	0	0	1	0	0	0	6344	1783	62	5	797	5	GFOD2	16	67709852	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	9774537	67709852	22644901	420	37718										
RANBP10	57610	broad.mit.edu	37	chr16	67768937	67768937	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgcaggcctacggtggggtaGaggttggcctgaggaggaga	20	6	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:67768937G>C	uc002eud.2	-	6	716	c.600C>G	c.(598-600)CTC>CTG	p.L200L	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Silent_p.L144L|RANBP10_uc010vjv.1_Silent_p.L83L|RANBP10_uc010vjx.1_Silent_p.L200L|RANBP10_uc010vjy.1_Silent_p.L68L	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	200	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		CGGTGGGGTAGAGGTTGGCCT	0.592													0	0	0	0.013537	0	12	81										C	67768937	G	C	67768937	2	2	126	1	0	0	0	0	0	0	0	1	13026	929	33	1		1	RANBP10	16	67768937	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	59085	67768937	22585816	421	37719										
CDH1	999	broad.mit.edu	37	chr16	68835746	68835746	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctacagaaagttttccaccAaagtcacgctgaatacagtg	7	11	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:68835746A>G	uc002ewg.1	+	3	461	c.337A>G	c.(337-339)AAA>GAA	p.K113E	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.K113E	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	113					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GTTTTCCACCAAAGTCACGCT	0.502			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.007413	0	14	96										G	68835746	A	G	68835746	3	3	126	1	0	0	0	0	1	0	0	0	3095	131	5	5	347	5	CDH1	16	68835746	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1066809	68835746	21519007	422	37720										
ZNF23	7571	broad.mit.edu	37	chr16	71482035	71482035	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggacactctgatgctgactGagctggaagctaaacctgaa	11	9	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:71482035G>C	uc002faf.2	-	6	2707	c.1893C>G	c.(1891-1893)CTC>CTG	p.L631L	ZNF23_uc002fad.2_Silent_p.L573L|ZNF23_uc002fae.2_Silent_p.L573L|ZNF23_uc010vmf.1_Silent_p.L573L|ZNF23_uc002fag.2_Silent_p.L573L|ZNF23_uc002fah.2_Silent_p.L631L|ZNF23_uc002fai.2_Silent_p.L670L	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	631	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		GATGCTGACTGAGCTGGAAGC	0.383													0	0	0	0.006214	0	10	102										C	71482035	G	C	71482035	2	2	126	1	0	0	0	0	0	0	0	1	17780	1277	45	1		1	ZNF23	16	71482035	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2646289	71482035	18872718	423	37721										
ZFPM1	161882	broad.mit.edu	37	chr16	88598530	88598530	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctccccggccgcagccgccaCagacgagaagcccaaagaga	11	17	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:88598530C>T	uc002fkv.2	+	7	866	c.833C>T	c.(832-834)ACA>ATA	p.T278I		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	278					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GCAGCCGCCACAGACGAGAAG	0.687													0	0	0	0.01441	0	34	50										T	88598530	C	T	88598530	3	4	126	1	0	0	0	0	1	0	0	0	17654	478	17	2	859	2	ZFPM1	16	88598530	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	17116495	88598530	1756223	424	37722										
FANCA	2175	broad.mit.edu	37	chr16	89813043	89813043	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtctggcacttggccagtatGaagtcgaccatcagggaggg	15	9	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr16:89813043G>A	uc002fou.1	-	35	3504	c.3462C>T	c.(3460-3462)TTC>TTT	p.F1154F	FANCA_uc010vpn.1_Silent_p.F1154F|FANCA_uc010vpo.1_Silent_p.F240F	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1154					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TGGCCAGTATGAAGTCGACCA	0.562			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.015359	0	30	92										A	89813043	G	A	89813043	2	1	126	1	0	0	0	0	0	0	0	1	5662	1281	45	1		1	FANCA	16	89813043	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1214513	89813043	541710	425	37723										
SLC25A11	8402	broad.mit.edu	37	chr17	4841336	4841336	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	accagcccgttcttgtattcCggcttcccatcaatcatccg	6	16	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:4841336C>T	uc002fzo.1	-	7	884	c.771G>A	c.(769-771)CCG>CCA	p.P257P	SLC25A11_uc002fzp.1_Silent_p.P253P|RNF167_uc002fzq.2_5'Flank|RNF167_uc002fzr.2_5'Flank|RNF167_uc002fzs.2_5'Flank|RNF167_uc002fzt.2_5'Flank|RNF167_uc002fzu.2_5'Flank|RNF167_uc002fzv.2_5'Flank|RNF167_uc002fzw.1_5'Flank|RNF167_uc002fzx.2_5'Flank	NM_003562	NP_003553	Q02978	M2OM_HUMAN	solute carrier family 25 member 11 isoform 1	257	Solcar 3.				gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity				0						TCTTGTATTCCGGCTTCCCAT	0.627													0	0	0	0.021022	0	34	140										T	4841336	C	T	4841336	2	4	126	1	0	0	0	0	0	0	0	1	14473	639	23	2		2	SLC25A11	17	4841336	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		4841336	76353874	426	37724										
ZNF232	7775	broad.mit.edu	37	chr17	5009199	5009199	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tccataagctttcccacattCtttacatataaaaggtttct	3	10	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:5009199C>G	uc002gas.2	-	5	1928	c.1174G>C	c.(1174-1176)GAA>CAA	p.E392Q	ZNF232_uc002gar.1_Missense_Mutation_p.E410Q|ZNF232_uc002gat.2_Missense_Mutation_p.E419Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	392	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTCCCACATTCTTTACATATA	0.443													0	0	0	0.01441	0	86	49										G	5009199	C	G	5009199	3	3	126	1	0	0	0	0	1	0	0	0	17782	922	32	1	83	1	ZNF232	17	5009199	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	167863	5009199	76186011	427	37725										
C1QBP	708	broad.mit.edu	37	chr17	5336678	5336678	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttcagactcgccagtggactGaaagctaacttccctgatag	9	11	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:5336678G>C	uc002gby.1	-	5	712	c.634C>G	c.(634-636)CAG>GAG	p.Q212E		NM_001212	NP_001203	Q07021	C1QBP_HUMAN	complement component 1, q subcomponent binding	212					blood coagulation, intrinsic pathway|immune response|interspecies interaction between organisms	mitochondrial matrix|nucleus|plasma membrane				ovary(1)	1						CCAGTGGACTGAAAGCTAACT	0.468													0	0	0	0.01441	0	48	132										C	5336678	G	C	5336678	3	2	126	1	0	0	0	0	1	0	0	0	1956	1299	45	1	222	1	C1QBP	17	5336678	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	327479	5336678	75858532	428	37726										
ACAP1	9744	broad.mit.edu	37	chr17	7250491	7250491	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccagtgctgcgactgccggGagccagccccggagtgggcc	16	16	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:7250491G>A	uc002ggd.2	+	14	1479	c.1273G>A	c.(1273-1275)GAG>AAG	p.E425K		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	425	Arf-GAP.|C4-type.|Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						CGACTGCCGGGAGCCAGCCCC	0.657													0	0	0	0.01892	0	20	60										A	7250491	G	A	7250491	3	1	126	1	0	0	0	0	1	0	0	0	118	1175	41	1	1327	1	ACAP1	17	7250491	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1913813	7250491	73944719	429	37727										
MYH13	8735	broad.mit.edu	37	chr17	10216043	10216043	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgccgtctccgtgttctcctCtgcttcctggagcctctggg	11	16	4	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10216043C>A	uc002gmk.1	-	31	4303	c.4213G>T	c.(4213-4215)GAG>TAG	p.E1405*		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1405	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTGTTCTCCTCTGCTTCCTGG	0.517													1	0	5.4927e-09	0.004482	7.35916e-09	7	22										A	10216043	C	A	10216043	4	1	126	1	0	0	0	0	0	1	0	0	10032	922	32	3	1647	3	MYH13	17	10216043	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2965552	10216043	70979167	430	37728										
MYH13	8735	broad.mit.edu	37	chr17	10243492	10243492	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtcttggtctcattgggaatCagacatcgtacaaagtgagg	12	7	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10243492C>G	uc002gmk.1	-	18	2121	c.2031G>C	c.(2029-2031)CTG>CTC	p.L677L		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	677	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CATTGGGAATCAGACATCGTA	0.428													0	0	0	0.010504	0	18	4										G	10243492	C	G	10243492	2	3	126	1	0	0	0	0	0	0	0	1	10032	813	29	1		1	MYH13	17	10243492	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	27449	10243492	70951718	431	37729										
MYH8	4626	broad.mit.edu	37	chr17	10309620	10309620	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tccaaatttatattgagtatGatcaatatcaatagatgcaa	5	5	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10309620G>A	uc002gmm.2	-	20	2361	c.2266C>T	c.(2266-2268)CAT>TAT	p.H756Y	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	756	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TATTGAGTATGATCAATATCA	0.378									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				0	0	0	0.006214	0	10	15										A	10309620	G	A	10309620	3	1	126	1	0	0	0	0	1	0	0	0	10041	1290	45	1	3631	1	MYH8	17	10309620	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	66128	10309620	70885590	432	37730										
MYH1	4619	broad.mit.edu	37	chr17	10395785	10395785	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccctgctcttcaccctcagcTtgttgacctgggactcagca	8	16	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:10395785T>G	uc002gmo.2	-	40	5862	c.5768A>C	c.(5767-5769)AAG>ACG	p.K1923T	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1923	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CACCCTCAGCTTGTTGACCTG	0.478													0	0	0	0.009535	0	29	72										G	10395785	T	G	10395785	3	3	126	1	0	0	0	0	1	0	0	0	10029	1609	56	5	55	5	MYH1	17	10395785	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	86165	10395785	70799425	433	37731										
ATPAF2	91647	broad.mit.edu	37	chr17	17924527	17924527	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaggttagcaccatggacttGagctgggcagctacaaactc	11	10	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:17924527G>C	uc002gse.1	-	7	795	c.642C>G	c.(640-642)CTC>CTG	p.L214L	ATPAF2_uc002gsd.1_RNA|ATPAF2_uc002gsf.1_RNA	NM_145691	NP_663729	Q8N5M1	ATPF2_HUMAN	ATP synthase mitochondrial F1 complex assembly	214					proton-transporting ATP synthase complex assembly	mitochondrion|nuclear speck	protein binding				0	all_neural(463;0.228)					CCATGGACTTGAGCTGGGCAG	0.592													0	0	0	0.013537	0	10	42										C	17924527	G	C	17924527	2	2	126	1	0	0	0	0	0	0	0	1	1201	1277	45	1		1	ATPAF2	17	17924527	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7528742	17924527	63270683	434	37732										
MYO15A	51168	broad.mit.edu	37	chr17	18042859	18042859	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccttttcaggtgcacaagttCctggacaagaaccacgacca	8	13	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:18042859C>T	uc010vxh.1	+	18	5483	c.5145C>T	c.(5143-5145)TTC>TTT	p.F1715F		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1715	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGCACAAGTTCCTGGACAAGA	0.592													0	0	0	0.01441	0	47	25										T	18042859	C	T	18042859	2	4	126	1	0	0	0	0	0	0	0	1	10063	854	30	1		1	MYO15A	17	18042859	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	118332	18042859	63152351	435	37733										
SLC47A2	146802	broad.mit.edu	37	chr17	19608794	19608794	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tagatgacagcctgggcagaGagatccaccacactgagcag	12	11	0	5			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:19608794G>C	uc002gwe.3	-	10	1147	c.972C>G	c.(970-972)CTC>CTG	p.L324L	SLC47A2_uc002gwg.3_Silent_p.L288L|SLC47A2_uc002gwf.3_Silent_p.L288L|SLC47A2_uc002gwh.3_RNA|SLC47A2_uc002gwi.2_RNA|SLC47A2_uc010cqs.1_RNA|SLC47A2_uc010cqt.1_RNA	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	solute carrier family 47, member 2 isoform 1	324	Extracellular (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					CCTGGGCAGAGAGATCCACCA	0.647													0	0	0	0.014758	0	5	23										C	19608794	G	C	19608794	2	2	126	1	0	0	0	0	0	0	0	1	14648	929	33	1		1	SLC47A2	17	19608794	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1565935	19608794	61586416	436	37734										
ALDH3A1	218	broad.mit.edu	37	chr17	19646659	19646659	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gatgtagagctcgtcctgctGagtctggggcgtcttctcca	13	11	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:19646659G>A	uc010cqu.2	-	2	610	c.280C>T	c.(280-282)CAG>TAG	p.Q94*	ALDH3A1_uc010vzd.1_Nonsense_Mutation_p.Q94*|ALDH3A1_uc002gwj.2_Nonsense_Mutation_p.Q94*|ALDH3A1_uc010cqv.2_Nonsense_Mutation_p.Q94*|ALDH3A1_uc002gwk.2_Silent_p.L10L|ALDH3A1_uc002gwl.1_Nonsense_Mutation_p.Q21*	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	94					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TCGTCCTGCTGAGTCTGGGGC	0.602													0	0	0	0.021523	0	26	161										A	19646659	G	A	19646659	4	1	126	1	0	0	0	0	0	1	0	0	497	1299	45	1	1117	1	ALDH3A1	17	19646659	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	37865	19646659	61548551	437	37735										
SSH2	85464	broad.mit.edu	37	chr17	27998974	27998974	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgtcggtgaagagagctggaGagtcgggccggtgggactgt	20	6	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27998974G>C	uc002heo.1	-	8	707	c.707C>G	c.(706-708)TCT>TGT	p.S236C	SSH2_uc010wbh.1_Missense_Mutation_p.S263C|SSH2_uc002hep.1_Missense_Mutation_p.S236C	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	236					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						GAGAGCTGGAGAGTCGGGCCG	0.448													0	0	0	0.00499	0	8	201										C	27998974	G	C	27998974	3	2	126	1	0	0	0	0	1	0	0	0	15184	942	33	1	3596	1	SSH2	17	27998974	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	8352315	27998974	53196236	438	37736			1	174		4	3	52	N	G	4.022278e-07
SSH2	85464	broad.mit.edu	37	chr17	27998987	27998987	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agctggagagtcgggccggtGggactgtacatcttgcattg	16	8	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27998987G>T	uc002heo.1	-	8	694	c.694C>A	c.(694-696)CAC>AAC	p.H232N	SSH2_uc010wbh.1_Missense_Mutation_p.H259N|SSH2_uc002hep.1_Missense_Mutation_p.H232N	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	232					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCGGGCCGGTGGGACTGTACA	0.448													1	0	1.87028e-06	0.012319	2.46985e-06	11	205										T	27998987	G	T	27998987	3	4	126	1	0	0	0	0	1	0	0	0	15184	1348	47	4	3609	4	SSH2	17	27998987	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	13	27998987	53196223	439	37737			1	174		4	3	52	N	G	4.022278e-07
SSH2	85464	broad.mit.edu	37	chr17	27999021	27999021	+	Silent	SNP	G	G	A													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgcattgcattccattcattGactgaggattgatctgagtt							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27999021G>A	uc002heo.1	-	8	660	c.660C>T	c.(658-660)GTC>GTT	p.V220V	SSH2_uc010wbh.1_Silent_p.V247V|SSH2_uc002hep.1_Silent_p.V220V	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	220					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCCATTCATTGACTGAGGATT	0.468													0	0	0	0.013537	0	10	187										A	27999021	G	A	27999021	2	1	126	1	0	0	0	0	0	0	0	1	15184	1277	45	1		1	SSH2	17	27999021	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	34	27999021	53196189	440	37738	197	2	1	174		4	3	52	N	G	4.022278e-07
SSH2	85464	broad.mit.edu	37	chr17	27999025	27999025	+	Missense_Mutation	SNP	G	G	A													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttgcattccattcattgactGaggattgatctgagttgata							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:27999025G>A	uc002heo.1	-	8	656	c.656C>T	c.(655-657)TCA>TTA	p.S219L	SSH2_uc010wbh.1_Missense_Mutation_p.S246L|SSH2_uc002hep.1_Missense_Mutation_p.S219L	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	219					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TTCATTGACTGAGGATTGATC	0.468													0	0	0	0.013537	0	10	194										A	27999025	G	A	27999025	3	1	126	1	0	0	0	0	1	0	0	0	15184	1294	45	1	3647	1	SSH2	17	27999025	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4	27999025	53196185	441	37739	197	2	1	174		4	3	52	N	G	4.022278e-07
CDK5R1	8851	broad.mit.edu	37	chr17	30814982	30814982	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acccccggccagccagctctCgggttcccagaccgggggct	13	18	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:30814982C>A	uc002hhn.2	+	2	565	c.344C>A	c.(343-345)TCG>TAG	p.S115*	CDK5R1_uc010wca.1_Nonsense_Mutation_p.S115*|CDK5R1_uc010ctc.2_5'UTR	NM_003885	NP_003876	Q15078	CD5R1_HUMAN	cyclin-dependent kinase 5, regulatory subunit 1	115					axon guidance|axonal fasciculation|brain development|cell proliferation|embryo development|ionotropic glutamate receptor signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of transcription, DNA-dependent|neuron cell-cell adhesion|neuron migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of neuron apoptosis|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation	axon|contractile fiber|cyclin-dependent protein kinase 5 holoenzyme complex|cytosol|dendritic spine|growth cone|neuromuscular junction|neuronal cell body|perinuclear region of cytoplasm|plasma membrane	cadherin binding|calcium ion binding|protein kinase binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.0938)			AGCCAGCTCTCGGGTTCCCAG	0.672													1	0	4.75426e-39	0.01441	6.74062e-39	76	164										A	30814982	C	A	30814982	4	1	126	1	0	0	0	0	0	1	0	0	3143	893	31	3	346	3	CDK5R1	17	30814982	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2815957	30814982	50380228	442	37740										
TMEM132E	124842	broad.mit.edu	37	chr17	32954018	32954018	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aagtgctcagcatcctcctcTatctggcccccaactcctcc	5	19	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:32954018T>G	uc002hif.2	+	3	998	c.670T>G	c.(670-672)TAT>GAT	p.Y224D		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	224	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CATCCTCCTCTATCTGGCCCC	0.632													0	0	0	0.014323	0	20	134										G	32954018	T	G	32954018	3	3	126	1	0	0	0	0	1	0	0	0	16045	1522	53	5	680	5	TMEM132E	17	32954018	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	2139036	32954018	48241192	443	37741										
DHRS11	79154	broad.mit.edu	37	chr17	34951498	34951498	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggacatcctctccatgttctCagctatccgttctcagcaca	6	15	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:34951498C>T	uc002hnd.2	+	2	459	c.245C>T	c.(244-246)TCA>TTA	p.S82L		NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	82						extracellular region	binding|oxidoreductase activity				0						TCCATGTTCTCAGCTATCCGT	0.542													0	0	0	0.01441	0	96	118										T	34951498	C	T	34951498	3	4	126	1	0	0	0	0	1	0	0	0	4487	838	29	1	251	1	DHRS11	17	34951498	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1997480	34951498	46243712	444	37742										
ORMDL3	94103	broad.mit.edu	37	chr17	38080454	38080454	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgtgcgctgtgcccacattCatcctgctgcccctctctgc	8	18	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:38080454C>T	uc002htj.1	-	2	143	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ORMDL3_uc002hti.1_RNA|ORMDL3_uc002htk.1_Missense_Mutation_p.M1I	NM_139280	NP_644809	Q8N138	ORML3_HUMAN	ORM1-like 3	1	Cytoplasmic (Potential).				ceramide metabolic process	integral to membrane|SPOTS complex	protein binding				0	Colorectal(19;0.000442)		Lung(15;0.0234)			TGCCCACATTCATCCTGCTGC	0.617													0	0	0	0.004007	0	15	119										T	38080454	C	T	38080454	3	4	126	1	0	0	0	0	1	0	0	0	11271	826	29	1	470	1	ORMDL3	17	38080454	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3128956	38080454	43114756	445	37743										
PSMD3	5709	broad.mit.edu	37	chr17	38151529	38151529	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	accctaattatccggctgcgGcacaacgtgattaagacagg	10	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:38151529G>A	uc002htn.1	+	8	1361	c.1197G>A	c.(1195-1197)CGG>CGA	p.R399R	PSMD3_uc010wen.1_RNA|PSMD3_uc010weo.1_Silent_p.R300R	NM_002809	NP_002800	O43242	PSMD3_HUMAN	proteasome 26S non-ATPase subunit 3	399	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			ovary(1)|pancreas(1)	2	Colorectal(19;0.000442)					TCCGGCTGCGGCACAACGTGA	0.537													0	0	0	0.011902	0	42	259										A	38151529	G	A	38151529	2	1	126	1	0	0	0	0	0	0	0	1	12699	1190	42	2		2	PSMD3	17	38151529	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	71075	38151529	43043681	446	37744										
KRT12	3859	broad.mit.edu	37	chr17	39019991	39019991	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcttcagcgtccttccgattCtgctcagcgatggtttcata	9	12	4	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:39019991C>T	uc002hvk.2	-	4	957	c.933G>A	c.(931-933)CAG>CAA	p.Q311Q		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	311	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CCTTCCGATTCTGCTCAGCGA	0.547													0	0	0	0.01441	0	63	33										T	39019991	C	T	39019991	2	4	126	1	0	0	0	0	0	0	0	1	8449	912	32	1		1	KRT12	17	39019991	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	868462	39019991	42175219	447	37745										
KRT38	8687	broad.mit.edu	37	chr17	39594846	39594846	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctcctcggagcaggacatgTcctgcaggctgatgccttca	12	13	1	1	rs143250758	byFrequency	TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:39594846T>G	uc002hwq.1	-	5	1340	c.917A>C	c.(916-918)GAC>GCC	p.D306A		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	306	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				GCAGGACATGTCCTGCAGGCT	0.632													0	0	0	0.014323	0	20	136										G	39594846	T	G	39594846	3	3	126	1	0	0	0	0	1	0	0	0	8475	1667	58	5	465	5	KRT38	17	39594846	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	574855	39594846	41600364	448	37746										
KRT36	8689	broad.mit.edu	37	chr17	39645947	39645947	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcaagcagctcccaaggccaGagaggcccgacctagcagaa	12	14	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:39645947G>C	uc002hwt.2	-	1	170	c.170C>G	c.(169-171)TCT>TGT	p.S57C		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	57	Head.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CCCAAGGCCAGAGAGGCCCGA	0.637													0	0	0	0.01441	0	104	53										C	39645947	G	C	39645947	3	2	126	1	0	0	0	0	1	0	0	0	8473	942	33	1	1261	1	KRT36	17	39645947	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	51101	39645947	41549263	449	37747										
UBTF	7343	broad.mit.edu	37	chr17	42290269	42290269	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgggcttctctgggatgtccGatttcttggcattctggatt	12	8	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:42290269G>T	uc002igb.2	-	6	645	c.578C>A	c.(577-579)TCG>TAG	p.S193*	UBTF_uc002igc.2_Nonsense_Mutation_p.S193*|UBTF_uc010czs.2_Nonsense_Mutation_p.S193*|UBTF_uc002igd.2_Nonsense_Mutation_p.S193*|UBTF_uc010czt.2_Nonsense_Mutation_p.S193*|UBTF_uc002ige.2_Nonsense_Mutation_p.S193*	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	193					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TGGGATGTCCGATTTCTTGGC	0.587													1	0	1.3612e-06	0.003163	1.80044e-06	13	346										T	42290269	G	T	42290269	4	4	126	1	0	0	0	0	0	1	0	0	16906	1059	37	3	1776	3	UBTF	17	42290269	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2644322	42290269	38904941	450	37748										
NMT1	4836	broad.mit.edu	37	chr17	43138785	43138785	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acgggaacggccatgagcacTgcagcgattgcgagaatgag	15	9	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:43138785T>C	uc002ihz.2	+	1	106	c.88T>C	c.(88-90)TGC>CGC	p.C30R	DCAKD_uc010dab.1_5'Flank|NMT1_uc010dac.1_RNA|NMT1_uc002iia.2_RNA	NM_021079	NP_066565	P30419	NMT1_HUMAN	N-myristoyltransferase 1	30					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity				0		Prostate(33;0.155)				CCATGAGCACTGCAGCGATTG	0.602													0	0	0	0.01441	0	58	16										C	43138785	T	C	43138785	3	2	126	1	0	0	0	0	1	0	0	0	10503	1580	55	5	90	5	NMT1	17	43138785	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	848516	43138785	38056425	451	37749										
TMEM100	55273	broad.mit.edu	37	chr17	53798395	53798395	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgctgccatgtgagcctttgGggctcccaggatctccttga	12	13	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:53798395G>A	uc002iuj.3	-	2	348	c.37C>T	c.(37-39)CCA>TCA	p.P13S	TMEM100_uc002iuk.3_Missense_Mutation_p.P13S	NM_018286	NP_060756	Q9NV29	TM100_HUMAN	transmembrane protein 100	13						integral to membrane					0						TGAGCCTTTGGGGCTCCCAGG	0.507													0	0	0	0.004656	0	25	159										A	53798395	G	A	53798395	3	1	126	1	0	0	0	0	1	0	0	0	16012	1232	43	2	371	2	TMEM100	17	53798395	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	10659610	53798395	27396815	452	37750										
EPX	8288	broad.mit.edu	37	chr17	56277646	56277650	+	Frame_Shift_Del	DEL	ATGCC	ATGCC	-													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgccaagctgaaccgtcaggAtgccatgttagtggatgagc							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:56277646_56277650delATGCC	uc002ivq.2	+	10	1684_1688	c.1598_1602delATGCC	c.(1597-1602)GATGCCfs	p.D533fs		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	533_534					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						AACCGTCAGGATGCCATGTTAGTGG	0.634											OREG0024608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)						21	221	---	---								-	56277650	ATGCC	-	56277646	7	5	126	1	0	1	0	1	0	0	0	0	5200	333	12	0	1636	0	EPX	17	56277646	Frame_Shift_Del	DEL	ATGCC	TCGA-H4-A2HQ-01A-11D-A17V-08	2479251	56277646	24917564	453	37751										
DDX42	11325	broad.mit.edu	37	chr17	61895172	61895172	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaattctgttccaactaactCagcacaacagggccataaca	6	12	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:61895172C>T	uc002jbu.2	+	19	2488	c.2231C>T	c.(2230-2232)TCA>TTA	p.S744L	DDX42_uc002jbv.2_Missense_Mutation_p.S744L|DDX42_uc002jbx.2_Missense_Mutation_p.S480L|DDX42_uc002jby.2_Missense_Mutation_p.S290L|DDX42_uc010wps.1_Missense_Mutation_p.S112L	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	744	Necessary for interaction with TP53BP2.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						CCAACTAACTCAGCACAACAG	0.542													0	0	0	0.01441	0	86	43										T	61895172	C	T	61895172	3	4	126	1	0	0	0	0	1	0	0	0	4362	838	29	1	2297	1	DDX42	17	61895172	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	5617526	61895172	19300038	454	37752										
GGA3	23163	broad.mit.edu	37	chr17	73242646	73242646	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctggatcttgtgggccagcaGtcggacggcgatctgtggcc	16	11	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:73242646G>T	uc002jni.1	-	3	154	c.145C>A	c.(145-147)CTG>ATG	p.L49M	GGA3_uc002jnj.1_Missense_Mutation_p.L49M|GGA3_uc010wrw.1_Translation_Start_Site|GGA3_uc002jnk.1_Translation_Start_Site|GGA3_uc010wrx.1_Intron|GGA3_uc010wry.1_Translation_Start_Site|GGA3_uc010wrz.1_Missense_Mutation_p.L49M	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	49	VHS.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TGGGCCAGCAGTCGGACGGCG	0.637													1	0	6.94344e-10	0.006122	9.36347e-10	15	77										T	73242646	G	T	73242646	3	4	126	1	0	0	0	0	1	0	0	0	6354	1020	36	4	2174	4	GGA3	17	73242646	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	11347474	73242646	7952564	455	37753										
SRP68	6730	broad.mit.edu	37	chr17	74068550	74068550	+	Frame_Shift_Del	DEL	G	G	-													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgccgccgccgccgccgcctGggacctgcttctcagcagcc							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr17:74068550delG	uc002jqk.1	-	1	58	c.23delC	c.(22-24)CCAfs	p.P8fs	SRP68_uc010wsu.1_5'UTR|SRP68_uc002jql.1_Frame_Shift_Del_p.P8fs|GALR2_uc002jqm.1_5'Flank	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	8					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						gccgccgccTGGGACCTGCTT	0.428																		25	124	---	---								-	74068550	G	-	74068550	7	5	126	1	0	1	0	1	0	0	0	0	15155	1348	47	0	1924	0	SRP68	17	74068550	Frame_Shift_Del	DEL	G	TCGA-H4-A2HQ-01A-11D-A17V-08	825904	74068550	7126660	456	37754										
APCDD1	147495	broad.mit.edu	37	chr18	10487667	10487667	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acgggaatgagtgcggggccGagggctcctggcaggtgggc	21	9	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:10487667G>A	uc002kom.3	+	5	1531	c.1177G>A	c.(1177-1179)GAG>AAG	p.E393K		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	393	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)		GTGCGGGGCCGAGGGCTCCTG	0.582													0	0	0	0.013726	0	32	84										A	10487667	G	A	10487667	3	1	126	1	0	0	0	0	1	0	0	0	765	1059	37	1	1195	1	APCDD1	18	10487667	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		10487667	67589581	457	37755										
MYO5B	4645	broad.mit.edu	37	chr18	47369614	47369614	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgcaggggctgcttactttCaggactttcttaatgccgtt	10	10	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:47369614C>T	uc002leb.2	-	34	4896	c.4608G>A	c.(4606-4608)CTG>CTA	p.L1536L	MYO5B_uc002ldz.2_Silent_p.L106L|MYO5B_uc002lea.2_Silent_p.L651L	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1536	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TGCTTACTTTCAGGACTTTCT	0.527													0	0	0	0.006214	0	9	30										T	47369614	C	T	47369614	2	4	126	1	0	0	0	0	0	0	0	1	10079	813	29	1		1	MYO5B	18	47369614	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	36881947	47369614	30707634	458	37756										
CDH7	1005	broad.mit.edu	37	chr18	63526247	63526247	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgaatttgccatggactatGagaccaccgtctgtgaaaat	9	9	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:63526247G>A	uc002ljz.2	+	9	1784	c.1459G>A	c.(1459-1461)GAG>AAG	p.E487K	CDH7_uc002lka.2_Missense_Mutation_p.E487K|CDH7_uc002lkb.2_Missense_Mutation_p.E487K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	487	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CATGGACTATGAGACCACCGT	0.428													0	0	0	0.014758	0	5	31										A	63526247	G	A	63526247	3	1	126	1	0	0	0	0	1	0	0	0	3115	1291	45	1	1489	1	CDH7	18	63526247	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	16156633	63526247	14551001	459	37757										
ZNF407	55628	broad.mit.edu	37	chr18	72343704	72343704	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcacatgggccacagaaggtCttttcctgtgatctttgtgg	12	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr18:72343704C>G	uc002llw.2	+	1	786	c.729C>G	c.(727-729)GTC>GTG	p.V243V	ZNF407_uc010xfc.1_Silent_p.V243V|ZNF407_uc010dqu.1_Silent_p.V243V|ZNF407_uc002llu.2_Silent_p.V242V	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CACAGAAGGTCTTTTCCTGTG	0.453													0	0	0	0.004656	0	27	93										G	72343704	C	G	72343704	2	3	126	1	0	0	0	0	0	0	0	1	17884	900	32	1		1	ZNF407	18	72343704	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8817457	72343704	5733544	460	37758										
MED16	10025	broad.mit.edu	37	chr19	875330	875330	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaaagtgggggcgcagcagcGacttcagggtggagctgatg	19	7	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:875330G>A	uc002lqd.1	-	10	1836	c.1685C>T	c.(1684-1686)TCG>TTG	p.S562L	MED16_uc010drw.1_Missense_Mutation_p.S387L|MED16_uc002lqe.2_Missense_Mutation_p.S551L|MED16_uc002lqf.2_Missense_Mutation_p.S551L|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Missense_Mutation_p.S482L|MED16_uc010xfx.1_Missense_Mutation_p.S407L|MED16_uc010xfy.1_Missense_Mutation_p.S139L|MED16_uc010xfz.1_5'Flank	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	562					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGCAGCAGCGACTTCAGGGT	0.627													0	0	0	0.021523	0	23	56										A	875330	G	A	875330	3	1	126	1	0	0	0	0	1	0	0	0	9434	1059	37	1	976	1	MED16	19	875330	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08		875330	58253653	461	37759										
CIRBP	1153	broad.mit.edu	37	chr19	1271019	1271019	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gagcaggtcttctcaaagtaCggacagatctctgaaggtga	12	8	3	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:1271019C>T	uc002lrr.3	+	2	236	c.87C>T	c.(85-87)TAC>TAT	p.Y29Y	C19orf23_uc010xgk.1_5'Flank|CIRBP_uc010dsg.1_Missense_Mutation_p.T12M|CIRBP_uc002lrt.2_Silent_p.Y29Y|CIRBP_uc010xgl.1_Silent_p.Y29Y|CIRBP_uc002lrv.3_Silent_p.Y29Y|CIRBP_uc002lru.2_RNA	NM_001280	NP_001271	Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	29	RRM.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCAAAGTACGGACAGATCT	0.418													0	0	0	0.00874	0	41	159										T	1271019	C	T	1271019	2	4	126	1	0	0	0	0	0	0	0	1	3433	547	19	2		2	CIRBP	19	1271019	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	395689	1271019	57857964	462	37760										
SPPL2B	56928	broad.mit.edu	37	chr19	2339822	2339822	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaccccatggtgtctcccaaGaaggtacatgaagcacaagc	10	12	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:2339822G>A	uc002lvs.2	+	6	680	c.600_splice	c.e6-1	p.K200_splice	SPPL2B_uc010dsw.1_Splice_Site_p.K172_splice|SPPL2B_uc010dsy.1_Splice_Site_p.K172_splice|SPPL2B_uc010dsz.1_Splice_Site_p.K200_splice|SPPL2B_uc002lvr.2_Splice_Site_p.K200_splice|SPPL2B_uc010dta.1_Intron|SPPL2B_uc002lvu.2_Silent_p.K5K	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTCTCCCAAGAAGGTACATG	0.677													0	0	0	0.001168	0	4	11										A	2339822	G	A	2339822	5	1	126	1	0	0	0	0	0	0	1	0	15088	956	33	1	621	1	SPPL2B	19	2339822	Splice_Site	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1068803	2339822	56789161	463	37761										
CELF5	60680	broad.mit.edu	37	chr19	3251037	3251037	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgccatcaaagctcagactgCcctgcacgagcagaagacct	9	15	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:3251037C>T	uc002lxm.2	+	2	351	c.314C>T	c.(313-315)GCC>GTC	p.A105V	CELF5_uc002lxl.1_Missense_Mutation_p.A105V|CELF5_uc010dtj.1_Missense_Mutation_p.A105V|CELF5_uc010xhg.1_5'UTR	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	105	RRM 1.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						GCTCAGACTGCCCTGCACGAG	0.597													0	0	0	0.012319	0	23	80										T	3251037	C	T	3251037	3	4	126	1	0	0	0	0	1	0	0	0	3219	739	26	2	320	2	CELF5	19	3251037	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	911215	3251037	55877946	464	37762										
ADAMTS10	81794	broad.mit.edu	37	chr19	8670587	8670587	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagcggaggatctggcaggcGggagccatagaggccacgtg	18	10	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:8670587G>T	uc002mkj.1	-	3	283	c.9C>A	c.(7-9)CCC>CCA	p.P3P	ADAMTS10_uc002mkk.1_5'UTR	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	3					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCTGGCAGGCGGGAGCCATAG	0.682													1	0	0.000308642	0.003163	0.000392558	11	22										T	8670587	G	T	8670587	2	4	126	1	0	0	0	0	0	0	0	1	256	1103	39	4		4	ADAMTS10	19	8670587	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	5419550	8670587	50458396	465	37763										
MUC16	94025	broad.mit.edu	37	chr19	9063595	9063595	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tacatcctcaggacccctccTcataagagtgctcatctgtg	7	14	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:9063595T>A	uc002mkp.2	-	3	24055	c.23851A>T	c.(23851-23853)AGG>TGG	p.R7951W		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7953	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGACCCCTCCTCATAAGAGTG	0.463													0	0	0	0.00499	0	17	55										A	9063595	T	A	9063595	3	1	126	1	0	0	0	0	1	0	0	0	9973	1550	54	5	20000	5	MUC16	19	9063595	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	393008	9063595	50065388	466	37764										
RAVER1	125950	broad.mit.edu	37	chr19	10444084	10444084	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atctagaggcggcagctcttCttccggcgcccggcgctccg	13	16	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:10444084C>T	uc002moa.2	-	1	231	c.151G>A	c.(151-153)GAA>AAA	p.E51K		NM_133452	NP_597709	Q8IY67	RAVR1_HUMAN	RAVER1	34						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GGCAGCTCTTCTTCCGGCGCC	0.672													0	0	0	0.009535	0	26	146										T	10444084	C	T	10444084	3	4	126	1	0	0	0	0	1	0	0	0	13094	922	32	1	2171	1	RAVER1	19	10444084	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1380489	10444084	48684899	467	37765										
SLC44A2	57153	broad.mit.edu	37	chr19	10745710	10745710	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctcatctttctccggaagaGaattctcatcgcgattgcac	8	12	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:10745710G>A	uc002mpf.2	+	12	1155	c.1016G>A	c.(1015-1017)AGA>AAA	p.R339K	SLC44A2_uc002mpe.3_Missense_Mutation_p.R337K|SLC44A2_uc002mpg.1_Missense_Mutation_p.R59K|SLC44A2_uc002mph.2_5'Flank	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	339	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	CTCCGGAAGAGAATTCTCATC	0.547													0	0	0	0.01441	0	64	234										A	10745710	G	A	10745710	3	1	126	1	0	0	0	0	1	0	0	0	14636	942	33	1	1097	1	SLC44A2	19	10745710	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	301626	10745710	48383273	468	37766										
RAB3D	9545	broad.mit.edu	37	chr19	11446394	11446394	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcgatgtcatacatgagcagGaagcccatggctccccggta	12	12	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:11446394G>C	uc002mqy.2	-	3	532	c.294C>G	c.(292-294)TTC>TTG	p.F98L		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	98					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						ACATGAGCAGGAAGCCCATGG	0.587													0	0	0	0.009718	0	36	155										C	11446394	G	C	11446394	3	2	126	1	0	0	0	0	1	0	0	0	12934	1165	41	1	377	1	RAB3D	19	11446394	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	700684	11446394	47682589	469	37767										
IL27RA	9466	broad.mit.edu	37	chr19	14150615	14150615	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acgtggacttttccgaggatGaccccctggaggccactgtc	12	13	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:14150615G>A	uc002mxx.2	+	4	850	c.427G>A	c.(427-429)GAC>AAC	p.D143N		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	143	Extracellular (Potential).|Fibronectin type-III 1.				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						TTCCGAGGATGACCCCCTGGA	0.607													0	0	0	0.01441	0	91	45										A	14150615	G	A	14150615	3	1	126	1	0	0	0	0	1	0	0	0	7681	1290	45	1	441	1	IL27RA	19	14150615	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2704221	14150615	44978368	470	37768										
ASF1B	55723	broad.mit.edu	37	chr19	14231399	14231399	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtcctgggtctctatggcctCcagcctgtccatgttgttgt	11	12	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:14231399C>A	uc002mye.2	-	4	653	c.481G>T	c.(481-483)GAG>TAG	p.E161*	PRKACA_uc002myc.2_5'Flank	NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	161					cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0						TCTATGGCCTCCAGCCTGTCC	0.632													1	0	0.000422831	0.004007	0.00053697	15	39										A	14231399	C	A	14231399	4	1	126	1	0	0	0	0	0	1	0	0	1038	864	30	3	131	3	ASF1B	19	14231399	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	80784	14231399	44897584	471	37769										
TECR	9524	broad.mit.edu	37	chr19	14675655	14675655	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctattacatcaatcaccctCtctacactccccctagtaag	2	17	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:14675655C>G	uc002mza.2	+	8	674	c.547C>G	c.(547-549)CTC>GTC	p.L183V	TECR_uc002mzb.2_Missense_Mutation_p.L198V|TECR_uc010xns.1_Missense_Mutation_p.L28V|TECR_uc002mzc.2_Missense_Mutation_p.L28V|TECR_uc002mzd.2_Missense_Mutation_p.L183V|TECR_uc002mze.2_Missense_Mutation_p.L9V|TECR_uc002mzf.1_5'Flank	NM_138501	NP_612510	Q9NZ01	TECR_HUMAN	glycoprotein, synaptic 2	183					fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity				0						CAATCACCCTCTCTACACTCC	0.632													0	0	0	0.010504	0	20	127										G	14675655	C	G	14675655	3	3	126	1	0	0	0	0	1	0	0	0	15742	913	32	1	577	1	TECR	19	14675655	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	444256	14675655	44453328	472	37770										
OCEL1	79629	broad.mit.edu	37	chr19	17337908	17337908	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccaagaagattgtgtttgagGatgagttgctctcccaggcc	12	9	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17337908G>A	uc002nfp.2	+	3	354	c.352G>A	c.(352-354)GAT>AAT	p.D118N		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	118										central_nervous_system(1)	1						TGTGTTTGAGGATGAGTTGCT	0.642													0	0	0	0.001984	0	6	171										A	17337908	G	A	17337908	3	1	126	1	0	0	0	0	1	0	0	0	10816	1174	41	1	362	1	OCEL1	19	17337908	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2662253	17337908	41791075	473	37771										
PLVAP	83483	broad.mit.edu	37	chr19	17476638	17476638	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgcagttgctccttggccagCtggcgctcttggtgctgcag	14	12	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17476638C>G	uc002ngk.1	-	3	686	c.636G>C	c.(634-636)CAG>CAC	p.Q212H		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	212	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CCTTGGCCAGCTGGCGCTCTT	0.562													0	0	0	0.004656	0	24	92										G	17476638	C	G	17476638	3	3	126	1	0	0	0	0	1	0	0	0	12116	796	28	4	708	4	PLVAP	19	17476638	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	138730	17476638	41652345	474	37772										
UNC13A	23025	broad.mit.edu	37	chr19	17735691	17735691	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttctccatggtgttcataaCcagcttccacagctccttca	5	14	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17735691C>T	uc002nhd.2	-	35	4408	c.4408G>A	c.(4408-4410)GTT>ATT	p.V1470I		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1382	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GTGTTCATAACCAGCTTCCAC	0.597													0	0	0	0.006214	0	9	44										T	17735691	C	T	17735691	3	4	126	1	0	0	0	0	1	0	0	0	16981	507	18	2	1003	2	UNC13A	19	17735691	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	259053	17735691	41393292	475	37773										
UNC13A	23025	broad.mit.edu	37	chr19	17737462	17737462	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttgctgtccagcaggtccatGatgggctgcaacacattgtc	11	11	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:17737462G>A	uc002nhd.2	-	34	4317	c.4317C>T	c.(4315-4317)ATC>ATT	p.I1439I		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1351	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GCAGGTCCATGATGGGCTGCA	0.647													0	0	0	0.004672	0	3	6										A	17737462	G	A	17737462	2	1	126	1	0	0	0	0	0	0	0	1	16981	1280	45	1		1	UNC13A	19	17737462	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1771	17737462	41391521	476	37774										
ZNF536	9745	broad.mit.edu	37	chr19	31040280	31040280	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggcgggcctgccaaagccgGagcgggggccccagagcctg	18	14	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:31040280G>A	uc002nsu.1	+	4	3892	c.3754G>A	c.(3754-3756)GAG>AAG	p.E1252K	ZNF536_uc010edd.1_Missense_Mutation_p.E1252K	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCAAAGCCGGAGCGGGGGCC	0.612													0	0	0	0.008871	0	19	49										A	31040280	G	A	31040280	3	1	126	1	0	0	0	0	1	0	0	0	17971	1175	41	1	3764	1	ZNF536	19	31040280	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	13302818	31040280	28088703	477	37775										
CCDC123	84902	broad.mit.edu	37	chr19	33444536	33444536	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aacacctgatttctgtgtggCacagcgtacaggtcatcact	9	11	3	1	rs140563444		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:33444536C>T	uc002nty.2	-	4	566	c.477G>A	c.(475-477)GTG>GTA	p.V159V	CCDC123_uc002ntx.2_5'UTR|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Silent_p.V159V|CCDC123_uc002nua.2_Silent_p.V159V|CCDC123_uc002nub.1_Silent_p.V51V	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	159						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					TTCTGTGTGGCACAGCGTACA	0.468													0	0	0	0.007413	0	17	741										T	33444536	C	T	33444536	2	4	126	1	0	0	0	0	0	0	0	1	2759	697	25	2		2	CCDC123	19	33444536	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2404256	33444536	25684447	478	37776										
CHST8	64377	broad.mit.edu	37	chr19	34263476	34263476	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctctttgtccgcgagcccttCgagaggctggtgtccgcctt	12	14	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:34263476C>G	uc002nus.3	+	5	1288	c.783C>G	c.(781-783)TTC>TTG	p.F261L	CHST8_uc002nut.3_Missense_Mutation_p.F261L|CHST8_uc002nuu.2_Missense_Mutation_p.F261L	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	261	PAPS (By similarity).|Lumenal (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					GCGAGCCCTTCGAGAGGCTGG	0.612													0	0	0	0.007413	0	18	191										G	34263476	C	G	34263476	3	3	126	1	0	0	0	0	1	0	0	0	3410	883	31	1	793	1	CHST8	19	34263476	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	818940	34263476	24865507	479	37777										
FFAR3	2865	broad.mit.edu	37	chr19	35850555	35850555	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gctatatctgcggtgaaagcCcggcgtggaggatctacgtg	15	9	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:35850555C>G	uc002nzd.2	+	2	838	c.763C>G	c.(763-765)CCG>GCG	p.P255A	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	255	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CGGTGAAAGCCCGGCGTGGAG	0.592													0	0	0	0.019004	0	34	583										G	35850555	C	G	35850555	3	3	126	1	0	0	0	0	1	0	0	0	5829	623	22	4	765	4	FFAR3	19	35850555	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1587079	35850555	23278428	480	37778										
IL28A	282616	broad.mit.edu	37	chr19	39759824	39759824	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgctgaaggactgcaggtgCcactcccgcctcttccccag	10	17	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:39759824C>A	uc002oku.1	+	3	277	c.225C>A	c.(223-225)TGC>TGA	p.C75*		NM_172138	NP_742150	Q8IZJ0	IL28A_HUMAN	interleukin 28A precursor	75					response to virus	extracellular space	cytokine activity			ovary(1)|skin(1)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;5.39e-26)|all cancers(26;4.1e-23)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			ACTGCAGGTGCCACTCCCGCC	0.637													1	0	8.12818e-05	0.001984	0.000104505	6	26										A	39759824	C	A	39759824	4	1	126	1	0	0	0	0	0	1	0	0	7682	747	26	4	235	4	IL28A	19	39759824	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3909269	39759824	19369159	481	37779										
CD3EAP	10849	broad.mit.edu	37	chr19	45910367	45910367	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tgcagatgctgctcggttctCttgtccccccaactttaccg	8	15	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:45910367C>T	uc002pbq.1	+	2	526	c.38C>T	c.(37-39)TCT>TTT	p.S13F	PPP1R13L_uc002pbn.2_5'Flank|PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Missense_Mutation_p.S15F	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	13					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		GCTCGGTTCTCTTGTCCCCCC	0.592													0	0	0	0.005443	0	27	221										T	45910367	C	T	45910367	3	4	126	1	0	0	0	0	1	0	0	0	3012	913	32	1	44	1	CD3EAP	19	45910367	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	6150543	45910367	13218616	482	37780										
PTOV1	53635	broad.mit.edu	37	chr19	50361229	50361229	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtctacgtgaaccagggggaGatcctgtgagtgctgggctg	17	8	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50361229G>C	uc002pqf.1	+	8	1043	c.873G>C	c.(871-873)GAG>GAC	p.E291D	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Missense_Mutation_p.E259D|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	291	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		ACCAGGGGGAGATCCTGTGAG	0.652													0	0	0	0.009096	0	4	123										C	50361229	G	C	50361229	3	2	126	1	0	0	0	0	1	0	0	0	12769	933	33	1	903	1	PTOV1	19	50361229	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4450862	50361229	8767754	483	37781										
TBC1D17	79735	broad.mit.edu	37	chr19	50387551	50387551	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acaggaccaacaagttctacGagggtcccgagaacccgggg	13	12	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50387551G>C	uc002pqo.2	+	11	1320	c.1168G>C	c.(1168-1170)GAG>CAG	p.E390Q	TBC1D17_uc010ybg.1_Missense_Mutation_p.E357Q|TBC1D17_uc002pqp.2_Missense_Mutation_p.E41Q|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.E41Q|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	390	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CAAGTTCTACGAGGGTCCCGA	0.632													0	0	0	0.010771	0	44	310										C	50387551	G	C	50387551	3	2	126	1	0	0	0	0	1	0	0	0	15603	1059	37	1	1210	1	TBC1D17	19	50387551	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	26322	50387551	8741432	484	37782			2	175		3	3	228	G		8.075345e-06
TBC1D17	79735	broad.mit.edu	37	chr19	50387587	50387587	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cggggctgggcctgctgaacGatatcctcctcacctactgc	11	15	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50387587G>A	uc002pqo.2	+	11	1356	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N	TBC1D17_uc010ybg.1_Missense_Mutation_p.D369N|TBC1D17_uc002pqp.2_Missense_Mutation_p.D53N|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.D53N|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	402	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCTGCTGAACGATATCCTCCT	0.662													0	0	0	0.01441	0	64	400										A	50387587	G	A	50387587	3	1	126	1	0	0	0	0	1	0	0	0	15603	1058	37	1	1246	1	TBC1D17	19	50387587	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	36	50387587	8741396	485	37783			2	175		3	3	228	G		8.075345e-06
TBC1D17	79735	broad.mit.edu	37	chr19	50387778	50387778	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acgtcattcagaacgaggtgGatgctttctggtgtttctgt	12	7	4	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:50387778G>C	uc002pqo.2	+	12	1458	c.1306G>C	c.(1306-1308)GAT>CAT	p.D436H	TBC1D17_uc010ybg.1_Missense_Mutation_p.D403H|TBC1D17_uc002pqp.2_Missense_Mutation_p.D87H|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_Missense_Mutation_p.D87H|TBC1D17_uc002pqs.2_RNA	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	436	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		GAACGAGGTGGATGCTTTCTG	0.592													0	0	0	0.019004	0	35	237										C	50387778	G	C	50387778	3	2	126	1	0	0	0	0	1	0	0	0	15603	1174	41	1	1352	1	TBC1D17	19	50387778	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	191	50387778	8741205	486	37784			2	175		3	3	228	G		8.075345e-06
FPR1	2357	broad.mit.edu	37	chr19	52249881	52249881	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgcaggacgcaaacacagcGgtccagagcaatgagggcga	14	10	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:52249881G>A	uc002pxq.2	-	2	462	c.367C>T	c.(367-369)CGC>TGC	p.R123C		NM_002029	NP_002020	P21462	FPR1_HUMAN	formyl peptide receptor 1	123	Cytoplasmic (Potential).				activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			ovary(1)|lung(1)|skin(1)	3		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CAAACACAGCGGTCCAGAGCA	0.552													0	0	0	0.005524	0	39	79										A	52249881	G	A	52249881	3	1	126	1	0	0	0	0	1	0	0	0	6038	1116	39	2	689	2	FPR1	19	52249881	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1862103	52249881	6879102	487	37785										
ZNF649	65251	broad.mit.edu	37	chr19	52393957	52393957	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agggcttttcccctgcacatGttcactaggacttaagctgt	9	11	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:52393957G>A	uc002pxy.2	-	5	1700	c.1432C>T	c.(1432-1434)CAT>TAT	p.H478Y	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_Intron	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CCCTGCACATGTTCACTAGGA	0.318													0	0	0	0.003163	0	15	319										A	52393957	G	A	52393957	3	1	126	1	0	0	0	0	1	0	0	0	18061	1377	48	2	89	2	ZNF649	19	52393957	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	144076	52393957	6735026	488	37786										
ZNF615	284370	broad.mit.edu	37	chr19	52507119	52507119	+	Translation_Start_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggaaactccgcctccttccTtcacttgatttctcttgttc	5	14	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:52507119T>A	uc002pye.1	-	3	138	c.-154A>T	c.(-156--152)GAAGG>GATGG		ZNF615_uc002pyf.1_Translation_Start_Site|ZNF615_uc002pyg.1_Translation_Start_Site|ZNF615_uc002pyh.1_Translation_Start_Site|ZNF615_uc010epi.1_Intron|ZNF615_uc010ydg.1_Intron	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCCTCCTTCCTTCACTTGATT	0.428													0	0	0	0.009096	0	4	14										A	52507119	T	A	52507119	1	1	126	1	0	0	0	0	0	0	0	0	18037	1624	56	5		5	ZNF615	19	52507119	Translation_Start_Site	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	113162	52507119	6621864	489	37787										
ZNF816A	125893	broad.mit.edu	37	chr19	53453850	53453850	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cacatttgtaaggtttctctCcagtgtgaagtatatgatgg	10	6	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:53453850C>G	uc002qal.1	-	5	1479	c.1178G>C	c.(1177-1179)GGA>GCA	p.G393A	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Missense_Mutation_p.G377A	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		AGGTTTCTCTCCAGTGTGAAG	0.393													0	0	0	0.01441	0	86	130										G	53453850	C	G	53453850	3	3	126	1	0	0	0	0	1	0	0	0	18174	855	30	1	781	1	ZNF816A	19	53453850	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	946731	53453850	5675133	490	37788										
RPL28	6158	broad.mit.edu	37	chr19	55897738	55897738	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccgccgccatgtctgcgcatCtgcaatggatggtcgtgcgg	14	13	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:55897738C>G	uc002qkv.2	+	2	55	c.13C>G	c.(13-15)CTG>GTG	p.L5V	uc002qku.2_5'Flank|RPL28_uc010yfz.1_Missense_Mutation_p.L5V|RPL28_uc010yfy.1_Missense_Mutation_p.L5V|RPL28_uc010yga.1_Missense_Mutation_p.L5V|RPL28_uc010ygb.1_Missense_Mutation_p.L5V|RPL28_uc002qkw.1_Missense_Mutation_p.L5V	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	5					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		GTCTGCGCATCTGCAATGGAT	0.607													0	0	0	0.00499	0	17	50										G	55897738	C	G	55897738	3	3	126	1	0	0	0	0	1	0	0	0	13577	912	32	1	15	1	RPL28	19	55897738	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2443888	55897738	3231245	491	37789										
UBE2S	27338	broad.mit.edu	37	chr19	55918274	55918274	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggtctgcggtcagtgtcgtCacctccttgtacaccaggcg	13	13	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:55918274C>A	uc002qkx.1	-	2	428	c.60G>T	c.(58-60)GTG>GTT	p.V20V	uc002qky.2_5'Flank	NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	20					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCAGTGTCGTCACCTCCTTGT	0.602													1	0	2.27525e-19	0.021523	3.18228e-19	25	159										A	55918274	C	A	55918274	2	1	126	1	0	0	0	0	0	0	0	1	16869	813	29	3		3	UBE2S	19	55918274	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	20536	55918274	3210709	492	37790										
ZNF581	51545	broad.mit.edu	37	chr19	56156283	56156283	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actcggaggtaaagcccttcGagtgtgacatctgtgggaag	14	8	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:56156283G>T	uc002qln.2	+	2	1062	c.346G>T	c.(346-348)GAG>TAG	p.E116*	ZNF581_uc002qlq.2_Nonsense_Mutation_p.E116*|CCDC106_uc002qlr.2_5'Flank	NM_016535	NP_057619	Q9P0T4	ZN581_HUMAN	zinc finger protein 581	116	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AAAGCCCTTCGAGTGTGACAT	0.607													1	0	0.00307968	0.00308	0.00387534	7	223										T	56156283	G	T	56156283	4	4	126	1	0	0	0	0	0	1	0	0	18010	1059	37	3	348	3	ZNF581	19	56156283	Nonsense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	238009	56156283	2972700	493	37791										
U2AF2	11338	broad.mit.edu	37	chr19	56175100	56175100	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgtcagagaacccctccgtCtatgtgcctggtgagtgggg	14	10	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:56175100C>G	uc002qlu.2	+	7	1787	c.732C>G	c.(730-732)GTC>GTG	p.V244V	U2AF2_uc002qlt.2_Silent_p.V244V	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	244					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		ACCCCTCCGTCTATGTGCCTG	0.587													0	0	0	0.01441	0	86	196										G	56175100	C	G	56175100	2	3	126	1	0	0	0	0	0	0	0	1	16820	900	32	1		1	U2AF2	19	56175100	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	18817	56175100	2953883	494	37792										
ZFP28	140612	broad.mit.edu	37	chr19	57058946	57058946	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggagtggctgaaccccattCagaggaacttgtacaggaag	14	8	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:57058946C>T	uc002qnj.2	+	3	441	c.370C>T	c.(370-372)CAG>TAG	p.Q124*	ZFP28_uc002qni.2_Nonsense_Mutation_p.Q124*|uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	124	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GAACCCCATTCAGAGGAACTT	0.527													0	0	0	0.006122	0	19	94										T	57058946	C	T	57058946	4	4	126	1	0	0	0	0	0	1	0	0	17639	827	29	1	380	1	ZFP28	19	57058946	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	883846	57058946	2070037	495	37793										
AURKC	6795	broad.mit.edu	37	chr19	57744973	57744973	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtctgtgcacaccccctcccTgaggtaggtcaggtggtggt	14	12	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr19:57744973T>A	uc002qoe.2	+	5	770	c.581T>A	c.(580-582)CTG>CAG	p.L194Q	AURKC_uc002qoc.2_Missense_Mutation_p.L175Q|AURKC_uc002qod.2_Missense_Mutation_p.L160Q|AURKC_uc010etv.2_Missense_Mutation_p.L191Q	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	194	Protein kinase.			SLR -> LPE (in Ref. 2; AAC77369).	cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ACCCCCTCCCTGAGGTAGGTC	0.483													0	0	0	0.005443	0	27	144										A	57744973	T	A	57744973	3	1	126	1	0	0	0	0	1	0	0	0	1224	1580	55	5	604	5	AURKC	19	57744973	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	686027	57744973	1384010	496	37794										
DEFB128	245939	broad.mit.edu	37	chr20	168750	168750	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tattgaagcattttttgagtCttgccccgtctgtgcatagg	10	8	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:168750C>T	uc002wcz.1	-	2	59	c.59G>A	c.(58-60)AGA>AAA	p.R20K		NM_001037732	NP_001032821	Q7Z7B8	DB128_HUMAN	beta-defensin 128 precursor	20					defense response to bacterium	extracellular region		p.R20fs*4(1)		breast(1)	1		all_cancers(10;0.00499)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TTTTTTGAGTCTTGCCCCGTC	0.423													0	0	0	0.00308	0	7	95										T	168750	C	T	168750	3	4	126	1	0	0	0	0	1	0	0	0	4414	913	32	1	226	1	DEFB128	20	168750	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		168750	62856770	497	37795										
TMC2	117532	broad.mit.edu	37	chr20	2573052	2573052	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttctgtcctttgggattttGaggtactattgtcaacatgc	9	7	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:2573052G>C	uc002wgf.1	+	8	946	c.931G>C	c.(931-933)GAG>CAG	p.E311Q	TMC2_uc002wgg.1_Missense_Mutation_p.E295Q|TMC2_uc010zpw.1_Missense_Mutation_p.E143Q|TMC2_uc010zpx.1_Missense_Mutation_p.E142Q	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	311	Extracellular (Potential).					integral to membrane				ovary(3)	3						TTGGGATTTTGAGGTACTATT	0.403													0	0	0	0.01441	0	70	113										C	2573052	G	C	2573052	3	2	126	1	0	0	0	0	1	0	0	0	15982	1291	45	1	961	1	TMC2	20	2573052	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2404302	2573052	60452468	498	37796										
CDC25B	994	broad.mit.edu	37	chr20	3783805	3783805	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aacatcgtggataagtttgtGattgtagactgcagataccc	10	7	0	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:3783805G>A	uc002wjn.2	+	13	2086	c.1308G>A	c.(1306-1308)GTG>GTA	p.V436V	CDC25B_uc010zqk.1_Silent_p.V372V|CDC25B_uc010zql.1_Silent_p.V358V|CDC25B_uc010zqm.1_Silent_p.V345V|CDC25B_uc002wjl.2_Silent_p.V324V|CDC25B_uc002wjm.2_Silent_p.V324V|CDC25B_uc002wjo.2_Silent_p.V422V|CDC25B_uc002wjp.2_Silent_p.V395V|CDC25B_uc002wjq.2_Silent_p.V236V|CDC25B_uc010gbc.2_Silent_p.V17V	NM_021873	NP_068659	P30305	MPIP2_HUMAN	cell division cycle 25B isoform 1	436	Rhodanese.				cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|ovary(2)	5						ATAAGTTTGTGATTGTAGACT	0.547													0	0	0	0.010818	0	29	55										A	3783805	G	A	3783805	2	1	126	1	0	0	0	0	0	0	0	1	3063	1277	45	1		1	CDC25B	20	3783805	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1210753	3783805	59241715	499	37797										
RIN2	54453	broad.mit.edu	37	chr20	19956386	19956386	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actatttgtctcagagctcgGagctggacccccccatcgag	10	14	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:19956386G>C	uc002wro.1	+	7	1753	c.1717G>C	c.(1717-1719)GAG>CAG	p.E573Q	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Missense_Mutation_p.E367Q	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	573					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TCAGAGCTCGGAGCTGGACCC	0.507													0	0	0	0.013537	0	12	41										C	19956386	G	C	19956386	3	2	126	1	0	0	0	0	1	0	0	0	13372	1175	41	1	1743	1	RIN2	20	19956386	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	16172581	19956386	43069134	500	37798										
ZNF337	26152	broad.mit.edu	37	chr20	25656356	25656356	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttggcttcaaggtaaagcctCgcccacaatccctgcagaaa	8	13	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:25656356C>T	uc002wva.2	-	4	2090	c.1568G>A	c.(1567-1569)CGA>CAA	p.R523Q	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.R491Q|ZNF337_uc002wvb.2_Missense_Mutation_p.R523Q|ZNF337_uc002wvc.2_Missense_Mutation_p.R523Q	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	523	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGTAAAGCCTCGCCCACAATC	0.488													0	0	0	0.010729	0	12	156										T	25656356	C	T	25656356	3	4	126	1	0	0	0	0	1	0	0	0	17850	884	31	1	691	1	ZNF337	20	25656356	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	5699970	25656356	37369164	501	37799										
MYLK2	85366	broad.mit.edu	37	chr20	30408240	30408240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agggagcctcaggcagccagGatcctggaaagcccagggtg	16	11	1	0	rs34471514		TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:30408240G>A	uc002wwq.2	+	3	466	c.364G>A	c.(364-366)GAT>AAT	p.D122N		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	122					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGGCAGCCAGGATCCTGGAAA	0.667													0	0	0	0.015359	0	31	109										A	30408240	G	A	30408240	3	1	126	1	0	0	0	0	1	0	0	0	10057	1174	41	1	370	1	MYLK2	20	30408240	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4751884	30408240	32617280	502	37800										
CBFA2T2	9139	broad.mit.edu	37	chr20	32199130	32199130	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agaaggtgcggactcttgttCttgcactggtggtaagtaca	13	7	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:32199130C>T	uc002wzg.1	+	4	973	c.436C>T	c.(436-438)CTT>TTT	p.L146F	CBFA2T2_uc010zug.1_Intron|CBFA2T2_uc002wze.1_Missense_Mutation_p.L137F|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.L117F|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	146	TAFH.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						GACTCTTGTTCTTGCACTGGT	0.478													0	0	0	0.020292	0	15	134										T	32199130	C	T	32199130	3	4	126	1	0	0	0	0	1	0	0	0	2697	913	32	1	484	1	CBFA2T2	20	32199130	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1790890	32199130	30826390	503	37801										
TRPC4AP	26133	broad.mit.edu	37	chr20	33596493	33596493	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gacgactctgctggctccttCttcatgacctgcagcagacg	10	14	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:33596493C>T	uc002xbk.2	-	13	1603	c.1569G>A	c.(1567-1569)AAG>AAA	p.K523K	TRPC4AP_uc002xbj.2_5'Flank|TRPC4AP_uc010zuq.1_Silent_p.K114K|TRPC4AP_uc002xbl.2_Silent_p.K515K|TRPC4AP_uc010zur.1_Silent_p.K484K|TRPC4AP_uc002xbm.1_Silent_p.K523K	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	523					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			CTGGCTCCTTCTTCATGACCT	0.507													0	0	0	0.01441	0	82	281										T	33596493	C	T	33596493	2	4	126	1	0	0	0	0	0	0	0	1	16578	912	32	1		1	TRPC4AP	20	33596493	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1397363	33596493	29429027	504	37802										
CPNE1	8904	broad.mit.edu	37	chr20	34219936	34219936	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tccagaaatggatctgatttTcccaggaagtcctgccaatg	9	10	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:34219936T>A	uc002xdf.2	-	8	831	c.468A>T	c.(466-468)GGA>GGT	p.G156G	CPNE1_uc002xdc.2_5'Flank|CPNE1_uc010zvj.1_Silent_p.G161G|CPNE1_uc002xde.2_Silent_p.G132G|CPNE1_uc002xdg.2_Silent_p.G156G|CPNE1_uc010gfi.2_RNA|CPNE1_uc010gfj.2_RNA|CPNE1_uc002xdh.2_Silent_p.G156G|CPNE1_uc002xdi.2_Silent_p.G156G|CPNE1_uc002xdj.2_Silent_p.G156G|CPNE1_uc002xdk.2_Silent_p.G156G|CPNE1_uc002xdl.2_Silent_p.G156G|CPNE1_uc002xdm.2_Silent_p.G156G|CPNE1_uc010gfk.1_Silent_p.G156G	NM_152931	NP_690908	Q99829	CPNE1_HUMAN	copine I isoform a	156	C2 2.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			upper_aerodigestive_tract(1)	1	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GATCTGATTTTCCCAGGAAGT	0.537													0	0	0	0.021523	0	25	162										A	34219936	T	A	34219936	2	1	126	1	0	0	0	0	0	0	0	1	3811	1770	62	5		5	CPNE1	20	34219936	Silent	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	623443	34219936	28805584	505	37803										
C20orf152	140894	broad.mit.edu	37	chr20	34596337	34596337	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gggctacaggggacaagcttCagcaggaagatcagaacctc	13	10	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:34596337C>T	uc002xes.1	+	9	1245	c.1089C>T	c.(1087-1089)TTC>TTT	p.F363F	C20orf152_uc002xer.1_Silent_p.F363F|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	363											0	Breast(12;0.00631)					GGACAAGCTTCAGCAGGAAGA	0.502													0	0	0	0.016723	0	13	147										T	34596337	C	T	34596337	2	4	126	1	0	0	0	0	0	0	0	1	2092	825	29	1		1	C20orf152	20	34596337	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	376401	34596337	28429183	506	37804										
SRC	6714	broad.mit.edu	37	chr20	36030892	36030892	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actacgtccaccgggaccttCgtgcagccaacatcctggtg	10	15	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:36030892C>T	uc002xgx.2	+	12	1620	c.1171C>T	c.(1171-1173)CGT>TGT	p.R391C	SRC_uc002xgy.2_Missense_Mutation_p.R391C	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	391	Protein kinase.				axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	CCGGGACCTTCGTGCAGCCAA	0.627													0	0	0	0.001168	0	6	112										T	36030892	C	T	36030892	3	4	126	1	0	0	0	0	1	0	0	0	15133	884	31	1	1205	1	SRC	20	36030892	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1434555	36030892	26994628	507	37805										
KIAA0406	9675	broad.mit.edu	37	chr20	36625251	36625251	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actggtccagccctggcactGatgggggcctgggtgactag	16	11	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:36625251G>A	uc002xhl.2	-	7	3107	c.2898C>T	c.(2896-2898)ATC>ATT	p.I966I	KIAA0406_uc002xhm.2_Silent_p.I966I	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	966							binding				0		Myeloproliferative disorder(115;0.00874)				CCCTGGCACTGATGGGGGCCT	0.597													0	0	0	0.01441	0	49	335										A	36625251	G	A	36625251	2	1	126	1	0	0	0	0	0	0	0	1	8173	1280	45	1		1	KIAA0406	20	36625251	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	594359	36625251	26400269	508	37806										
MAFB	9935	broad.mit.edu	37	chr20	39316774	39316774	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agggtccgccgcttctgcttCaggcggatcacctcgtcctt	11	15	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:39316774C>T	uc002xji.2	-	1	1103	c.717G>A	c.(715-717)CTG>CTA	p.L239L		NM_005461	NP_005452	Q9Y5Q3	MAFB_HUMAN	transcription factor MAFB	239	Basic motif.				negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		Myeloproliferative disorder(115;0.00878)				GCTTCTGCTTCAGGCGGATCA	0.632			T	IGH@	MM								0	0	0	0.00308	0	7	60										T	39316774	C	T	39316774	2	4	126	1	0	0	0	0	0	0	0	1	9158	813	29	1		1	MAFB	20	39316774	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2691523	39316774	23708746	509	37807										
SFRS6	6431	broad.mit.edu	37	chr20	42086760	42086760	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtggctatggccgcctcctCgaagtagacctcaaaaatgg	11	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:42086760C>G	uc010zwg.1	+	1	257	c.87C>G	c.(85-87)CTC>CTG	p.L29L	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Silent_p.L29L	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	29	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GCCGCCTCCTCGAAGTAGACC	0.647													0	0	0	0.007413	0	17	87										G	42086760	C	G	42086760	2	3	126	1	0	0	0	0	0	0	0	1	14181	871	31	1		1	SFRS6	20	42086760	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2769986	42086760	20938760	510	37808										
TOX2	84969	broad.mit.edu	37	chr20	42635186	42635186	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	catgtctttttgatgttttaGacctacaacggccagagcga	9	9	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:42635186G>A	uc002xlf.3	+	3	210	c.193_splice	c.e3-1	p.T65_splice	TOX2_uc010ggo.2_Splice_Site_p.T56_splice|TOX2_uc002xle.3_Splice_Site_p.T14_splice|TOX2_uc010ggp.2_Splice_Site_p.T14_splice|TOX2_uc002xlg.2_Splice_Site_p.T14_splice	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGATGTTTTAGACCTACAACG	0.453													0	0	0	0.010818	0	30	241										A	42635186	G	A	42635186	5	1	126	1	0	0	0	0	0	0	1	0	16375	956	33	1	305	1	TOX2	20	42635186	Splice_Site	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	548426	42635186	20390334	511	37809										
WISP2	8839	broad.mit.edu	37	chr20	43355830	43355830	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaccacctgtgggctgggcaTggccacccgggtgtccaacc	14	15	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:43355830T>A	uc002xmn.2	+	5	988	c.635T>A	c.(634-636)ATG>AAG	p.M212K	uc002xml.1_Intron|uc002xmm.1_Intron|WISP2_uc002xmp.2_Missense_Mutation_p.M212K|WISP2_uc002xmq.2_Missense_Mutation_p.W130R	NM_003881	NP_003872	O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	212	TSP type-1.				cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				GGGCTGGGCATGGCCACCCGG	0.687													0	0	0	0.00874	0	43	128										A	43355830	T	A	43355830	3	1	126	1	0	0	0	0	1	0	0	0	17370	1464	51	5	649	5	WISP2	20	43355830	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	720644	43355830	19669690	512	37810										
KCNK15	60598	broad.mit.edu	37	chr20	43379189	43379189	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcctcctggggctcacggtcAttggcgccttcctcaacctg	10	16	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:43379189A>C	uc002xmr.2	+	2	767	c.703A>C	c.(703-705)ATT>CTT	p.I235L		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	235	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GCTCACGGTCATTGGCGCCTT	0.612													0	0	0	0.01441	0	46	193										C	43379189	A	C	43379189	3	2	126	1	0	0	0	0	1	0	0	0	8062	217	8	5	709	5	KCNK15	20	43379189	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	23359	43379189	19646331	513	37811										
PI3	5266	broad.mit.edu	37	chr20	43804728	43804728	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actgactgcccaggaatcaaGaagtgctgtgaaggctcttg	12	9	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:43804728G>A	uc002xng.2	+	2	330	c.306G>A	c.(304-306)AAG>AAA	p.K102K		NM_002638	NP_002629	P19957	ELAF_HUMAN	elafin preproprotein	102	WAP.				copulation	proteinaceous extracellular matrix	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CAGGAATCAAGAAGTGCTGTG	0.542													0	0	0	0.00499	0	16	134										A	43804728	G	A	43804728	2	1	126	1	0	0	0	0	0	0	0	1	11870	933	33	1		1	PI3	20	43804728	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	425539	43804728	19220792	514	37812										
NCOA3	8202	broad.mit.edu	37	chr20	46279914	46279914	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagcagcaaacccaggccttCagcccacctcctaatgtgac	7	17	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:46279914C>T	uc002xtk.2	+	20	4045	c.3840C>T	c.(3838-3840)TTC>TTT	p.F1280F	NCOA3_uc010ght.1_Silent_p.F1271F|NCOA3_uc002xtl.2_Silent_p.F1276F|NCOA3_uc002xtm.2_Silent_p.F1275F|NCOA3_uc002xtn.2_Silent_p.F1279F|NCOA3_uc010zyc.1_Silent_p.F1075F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1280	Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CCCAGGCCTTCAGCCCACCTC	0.308													0	0	0	0.01892	0	25	100										T	46279914	C	T	46279914	2	4	126	1	0	0	0	0	0	0	0	1	10230	825	29	1		1	NCOA3	20	46279914	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2475186	46279914	16745606	515	37813										
PREX1	57580	broad.mit.edu	37	chr20	47274684	47274684	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agggcctcacctcagccagcGagcccctctggacggacttc	11	17	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:47274684G>A	uc002xtw.1	-	17	1987	c.1964C>T	c.(1963-1965)TCG>TTG	p.S655L	PREX1_uc002xtv.1_5'Flank	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	655	PDZ.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCAGCCAGCGAGCCCCTCTG	0.657											OREG0026010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	285	545										A	47274684	G	A	47274684	3	1	126	1	0	0	0	0	1	0	0	0	12476	1059	37	1	3111	1	PREX1	20	47274684	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	994770	47274684	15750836	516	37814										
SLC9A8	23315	broad.mit.edu	37	chr20	48503325	48503325	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cggagcacctgtcggagctcAcggaggaggagtacgaggcc	17	11	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:48503325A>G	uc002xuv.1	+	15	1738	c.1528A>G	c.(1528-1530)ACG>GCG	p.T510A	SLC9A8_uc010zym.1_Missense_Mutation_p.T210A|SLC9A8_uc010gid.2_Missense_Mutation_p.T134A	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	510						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			GTCGGAGCTCACGGAGGAGGA	0.647													0	0	0	0.01441	0	100	100										G	48503325	A	G	48503325	3	3	126	1	0	0	0	0	1	0	0	0	14720	159	6	5	1586	5	SLC9A8	20	48503325	Missense_Mutation	SNP	A	TCGA-H4-A2HQ-01A-11D-A17V-08	1228641	48503325	14522195	517	37815										
PCK1	5105	broad.mit.edu	37	chr20	56136482	56136482	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcagaaatgcctcctcagctGcaaaacggcctgaacctctc	8	15	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:56136482G>A	uc002xyn.3	+	2	178	c.15G>A	c.(13-15)CTG>CTA	p.L5L	PCK1_uc010zzm.1_5'UTR	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	5					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CTCCTCAGCTGCAAAACGGCC	0.527													0	0	0	0.010771	0	38	227										A	56136482	G	A	56136482	2	1	126	1	0	0	0	0	0	0	0	1	11581	1306	46	2		2	PCK1	20	56136482	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	7633157	56136482	6889038	518	37816										
GNAS	2778	broad.mit.edu	37	chr20	57429712	57429712	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcccctgacgccccagccgaTccagatgccggggcggcccc	13	20	0	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:57429712T>A	uc002xzw.2	+	1	1677	c.1392T>A	c.(1390-1392)GAT>GAA	p.D464E	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CCCCAGCCGATCCAGATGCCG	0.796			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			0	0	0	0.001984	0	7	3										A	57429712	T	A	57429712	3	1	126	1	0	0	0	0	1	0	0	0	6510	1435	50	5	2136	5	GNAS	20	57429712	Missense_Mutation	SNP	T	TCGA-H4-A2HQ-01A-11D-A17V-08	1293230	57429712	5595808	519	37817										
PRIC285	85441	broad.mit.edu	37	chr20	62196310	62196310	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctgctcccaggtgctggcctCaggcagcacctcccggacga	12	17	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:62196310C>G	uc002yfm.2	-	9	4757	c.3865G>C	c.(3865-3867)GAG>CAG	p.E1289Q	PRIC285_uc002yfl.1_Missense_Mutation_p.E720Q	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1289					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTGCTGGCCTCAGGCAGCACC	0.672													0	0	0	0.004482	0	9	51										G	62196310	C	G	62196310	3	3	126	1	0	0	0	0	1	0	0	0	12485	835	29	1	4132	1	PRIC285	20	62196310	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4766598	62196310	829210	520	37818										
UCKL1	54963	broad.mit.edu	37	chr20	62571633	62571633	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgagcagcgacagcaaaaaGatcttgtcctcaggcacgtc	10	11	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:62571633G>A	uc010gkn.2	-	14	1480	c.1437C>T	c.(1435-1437)ATC>ATT	p.I479I	UCKL1_uc002yhj.2_Silent_p.I122I|UCKL1_uc011abm.1_Silent_p.I464I|UCKL1_uc011abn.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	479					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ACAGCAAAAAGATCTTGTCCT	0.587													0	0	0	0.021022	0	34	53										A	62571633	G	A	62571633	2	1	126	1	0	0	0	0	0	0	0	1	16922	932	33	1		1	UCKL1	20	62571633	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	375323	62571633	453887	521	37819										
PRPF6	24148	broad.mit.edu	37	chr20	62624835	62624835	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	caacagcagttctcagacctCaaggtgagccgatgaagcgg	12	11	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr20:62624835C>G	uc002yho.2	+	4	603	c.435C>G	c.(433-435)CTC>CTG	p.L145L	PRPF6_uc002yhp.2_Silent_p.L145L	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	145					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TCTCAGACCTCAAGGTGAGCC	0.463													0	0	0	0.004656	0	23	38										G	62624835	C	G	62624835	2	3	126	1	0	0	0	0	0	0	0	1	12574	813	29	1		1	PRPF6	20	62624835	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	53202	62624835	400685	522	37820										
HSPA13	6782	broad.mit.edu	37	chr21	15746243	15746243	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gaggtcttcattaagggtatCaaagagtttccgtgatattt	10	5	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:15746243C>G	uc002yjt.2	-	5	1180	c.1111G>C	c.(1111-1113)GAT>CAT	p.D371H	HSPA13_uc011abx.1_Missense_Mutation_p.D163H	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	371						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						TTAAGGGTATCAAAGAGTTTC	0.408													0	0	0	0.007835	0	40	115										G	15746243	C	G	15746243	3	3	126	1	0	0	0	0	1	0	0	0	7406	826	29	1	308	1	HSPA13	21	15746243	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		15746243	32383652	523	37821										
KRTAP13-3	337960	broad.mit.edu	37	chr21	31798111	31798111	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tggcaggtgctgggagagcaGaggtcagtgctgtagaccag	18	7	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:31798111G>A	uc002yob.1	-	1	120	c.120C>T	c.(118-120)CTC>CTT	p.L40L		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	40						intermediate filament				ovary(1)|lung(1)	2						TGGGAGAGCAGAGGTCAGTGC	0.582													0	0	0	0.004482	0	8	82										A	31798111	G	A	31798111	2	1	126	1	0	0	0	0	0	0	0	1	8524	929	33	1		1	KRTAP13-3	21	31798111	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	16051868	31798111	16331784	524	37822										
SON	6651	broad.mit.edu	37	chr21	34927545	34927545	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ccgccggagaagatcaaggtCtgtggtaagaagacgaagct	14	8	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:34927545C>T	uc002yse.1	+	3	6057	c.6008C>T	c.(6007-6009)TCT>TTT	p.S2003F	SON_uc002ysb.1_Missense_Mutation_p.S2003F|SON_uc002ysc.2_Missense_Mutation_p.S2003F|SON_uc002ysd.2_Missense_Mutation_p.S994F|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S994F	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2003	2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V- V-R-R-R-S-F-S-I-S.|3-2.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						AGATCAAGGTCTGTGGTAAGA	0.254													0	0	0	0.004656	0	25	126										T	34927545	C	T	34927545	3	4	126	1	0	0	0	0	1	0	0	0	14926	913	32	1	6018	1	SON	21	34927545	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3129434	34927545	13202350	525	37823										
DOPEY2	9980	broad.mit.edu	37	chr21	37602841	37602841	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cgtttccccctctgaagtctGaggacagtgggatcgggctc	13	12	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:37602841G>C	uc002yvg.2	+	14	1838	c.1759G>C	c.(1759-1761)GAG>CAG	p.E587Q	DOPEY2_uc011aeb.1_Missense_Mutation_p.E587Q	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	587					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCTGAAGTCTGAGGACAGTGG	0.507													0	0	0	0.007291	0	29	137										C	37602841	G	C	37602841	3	2	126	1	0	0	0	0	1	0	0	0	4708	1291	45	1	1809	1	DOPEY2	21	37602841	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2675296	37602841	10527054	526	37824										
DSCR3	10311	broad.mit.edu	37	chr21	38612875	38612875	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tttacagttccttccatggtCaaagacactccctggtgttg	8	11	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:38612875C>G	uc002ywf.1	-	3	362	c.123G>C	c.(121-123)TTG>TTC	p.L41F	DSCR3_uc010gnm.1_RNA|DSCR3_uc010gnn.1_5'UTR|DSCR3_uc010gnl.2_Missense_Mutation_p.L41F|DSCR3_uc011aeg.1_Missense_Mutation_p.L41F|DSCR3_uc011aeh.1_Intron	NM_006052	NP_006043	O14972	DSCR3_HUMAN	Down syndrome critical region protein 3	41					vacuolar transport	nucleus|retromer complex					0						CTTCCATGGTCAAAGACACTC	0.443													0	0	0	0.014758	0	4	96										G	38612875	C	G	38612875	3	3	126	1	0	0	0	0	1	0	0	0	4771	825	29	1	798	1	DSCR3	21	38612875	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	1010034	38612875	9517020	527	37825										
LCA5L	150082	broad.mit.edu	37	chr21	40800153	40800153	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttcttctccttttcttttacCacaggctgctttaaataatt	3	10	3	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:40800153C>T	uc002yxu.2	-	4	580	c.267G>A	c.(265-267)GTG>GTA	p.V89V	LCA5L_uc002yxv.2_Silent_p.V89V|LCA5L_uc002yxw.1_Silent_p.V89V|LCA5L_uc002yxx.1_Intron|LCA5L_uc002yxy.2_RNA	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	89											0		Prostate(19;1.2e-06)				TTTCTTTTACCACAGGCTGCT	0.323													0	0	0	0.01441	0	54	107										T	40800153	C	T	40800153	2	4	126	1	0	0	0	0	0	0	0	1	8657	581	21	2		2	LCA5L	21	40800153	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2187278	40800153	7329742	528	37826										
UBASH3A	53347	broad.mit.edu	37	chr21	43833287	43833287	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagccccgcagacgtcatccGggaattcgccatgaccttcg	10	16	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:43833287G>A	uc002zbe.2	+	4	545	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	UBASH3A_uc002zbf.2_Missense_Mutation_p.R170Q|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.R170Q	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	170						cytosol|nucleus				ovary(3)	3						GACGTCATCCGGGAATTCGCC	0.622													0	0	0	0.016522	0	20	139										A	43833287	G	A	43833287	3	1	126	1	0	0	0	0	1	0	0	0	16836	1116	39	2	523	2	UBASH3A	21	43833287	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	3033134	43833287	4296608	529	37827										
LRRC3	81543	broad.mit.edu	37	chr21	45876889	45876889	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cctgcggctgctggacctgtCttacaaccgcatccagagga	11	14	1	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:45876889C>G	uc002zfa.2	+	2	655	c.362C>G	c.(361-363)TCT>TGT	p.S121C		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	121	LRR 3.					integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		CTGGACCTGTCTTACAACCGC	0.672													0	0	0	0.014323	0	19	60										G	45876889	C	G	45876889	3	3	126	1	0	0	0	0	1	0	0	0	8984	913	32	1	364	1	LRRC3	21	45876889	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	2043602	45876889	2253006	530	37828										
KRTAP10-10	353333	broad.mit.edu	37	chr21	46058039	46058039	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ctcctctgccgccccgtgtgCtcccgccctgcctgctacag	9	21	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr21:46058039C>T	uc002zfq.2	+	1	767	c.705C>T	c.(703-705)TGC>TGT	p.C235C	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	235						keratin filament					0						GCCCCGTGTGCTCCCGCCCTG	0.697													0	0	0	0.01441	0	61	178										T	46058039	C	T	46058039	2	4	126	1	0	0	0	0	0	0	0	1	8506	805	28	2		2	KRTAP10-10	21	46058039	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	181150	46058039	2071856	531	37829										
HIRA	7290	broad.mit.edu	37	chr22	19384471	19384471	+	Splice_Site	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tctcagagtagctagaatttCtgtgaagaaaaaaggaatgt	10	4	2	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:19384471C>T	uc002zpf.1	-	7	714	c.494_splice	c.e7-1	p.E165_splice	HIRA_uc011agx.1_Splice_Site_p.E31_splice|HIRA_uc010grn.1_Splice_Site_p.E165_splice|HIRA_uc010gro.1_Splice_Site_p.E121_splice|HIRA_uc010grp.2_Splice_Site	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective						chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GCTAGAATTTCTGTGAAGAAA	0.483													0	0	0	0.016723	0	13	64										T	19384471	C	T	19384471	5	4	126	1	0	0	0	0	0	0	1	0	7120	927	32	1	2636	1	HIRA	22	19384471	Splice_Site	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		19384471	31920095	532	37830										
ARVCF	421	broad.mit.edu	37	chr22	19967410	19967410	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cagtgccccacaggcccggcGccgcacctcagcccgcgggt	13	20	1	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:19967410G>A	uc002zqz.2	-	6	1523	c.1252C>T	c.(1252-1254)CGC>TGC	p.R418C	ARVCF_uc002zqy.2_5'Flank	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	418	ARM 2.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					CAGGCCCGGCGCCGCACCTCA	0.687													0	0	0	0.001168	0	5	14										A	19967410	G	A	19967410	3	1	126	1	0	0	0	0	1	0	0	0	1003	1087	38	2	1692	2	ARVCF	22	19967410	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	582939	19967410	31337156	533	37831										
CABIN1	23523	broad.mit.edu	37	chr22	24439456	24439456	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggatccccctggctcgccatGcttttgaggaagggctgcgg	15	12	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:24439456G>A	uc002zzi.1	+	6	563	c.436G>A	c.(436-438)GCT>ACT	p.A146T	CABIN1_uc002zzj.1_Missense_Mutation_p.A146T|CABIN1_uc002zzl.1_Missense_Mutation_p.A146T|CABIN1_uc010guk.1_Missense_Mutation_p.A101T|CABIN1_uc002zzk.1_Missense_Mutation_p.A101T	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	146	TPR 3.				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GGCTCGCCATGCTTTTGAGGA	0.537													0	0	0	0.014323	0	22	83										A	24439456	G	A	24439456	3	1	126	1	0	0	0	0	1	0	0	0	2528	1319	46	2	454	2	CABIN1	22	24439456	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	4472046	24439456	26865110	534	37832										
PATZ1	23598	broad.mit.edu	37	chr22	31731850	31731850	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcaaaagaagcattgcaggtCtgaaggcagaaaagaaaatg	12	5	1	4			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:31731850C>G	uc003akq.2	-	3	1997	c.1336_splice	c.e3-1	p.T446_splice	PATZ1_uc003akp.2_Splice_Site_p.T446_splice|PATZ1_uc003akr.2_Splice_Site_p.T446_splice	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1						negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CATTGCAGGTCTGAAGGCAGA	0.552													0	0	0	0.009096	0	4	76										G	31731850	C	G	31731850	5	3	126	1	0	0	0	0	0	0	1	0	11476	927	32	1	740	1	PATZ1	22	31731850	Splice_Site	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	7292394	31731850	19572716	535	37833										
L3MBTL2	83746	broad.mit.edu	37	chr22	41625593	41625593	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	cccctcagacaggggtccaaGaagcccctgctggaggacga	13	14	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:41625593G>A	uc003azo.2	+	16	1992	c.1938G>A	c.(1936-1938)AAG>AAA	p.K646K	L3MBTL2_uc003azn.2_RNA|CHADL_uc003azq.3_3'UTR|CHADL_uc010gyj.2_3'UTR	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	646					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						AGGGGTCCAAGAAGCCCCTGC	0.557													0	0	0	0.020292	0	15	40										A	41625593	G	A	41625593	2	1	126	1	0	0	0	0	0	0	0	1	8592	933	33	1		1	L3MBTL2	22	41625593	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	9893743	41625593	9678973	536	37834										
PARVB	29780	broad.mit.edu	37	chr22	44514968	44514968	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtggaggagaggatcattgtGaagcagctggaggaagacct	17	5	1	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:44514968G>A	uc003ben.2	+	4	376	c.324G>A	c.(322-324)GTG>GTA	p.V108V	PARVB_uc003bem.2_Silent_p.V141V|PARVB_uc010gzn.2_Silent_p.V56V|PARVB_uc003beo.2_Silent_p.V71V	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	108	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				GGATCATTGTGAAGCAGCTGG	0.587													0	0	0	0.01441	0	48	149										A	44514968	G	A	44514968	2	1	126	1	0	0	0	0	0	0	0	1	11469	1277	45	1		1	PARVB	22	44514968	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	2889375	44514968	6789598	537	37835										
FBLN1	2192	broad.mit.edu	37	chr22	45970446	45970446	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcaagtcctgccgccccaacGatgtcacatgcgtgttcgac	9	15	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:45970446G>A	uc003bgj.1	+	15	1900	c.1753G>A	c.(1753-1755)GAT>AAT	p.D585N		NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	585					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCGCCCCAACGATGTCACATG	0.627													0	0	0	0.013537	0	12	47										A	45970446	G	A	45970446	3	1	126	1	0	0	0	0	1	0	0	0	5698	1058	37	1	2291	1	FBLN1	22	45970446	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	1455478	45970446	5334120	538	37836										
PKDREJ	10343	broad.mit.edu	37	chr22	46655230	46655230	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gtatcaacagaaagccatttCtggcatatgaacagccaaat	7	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:46655230C>G	uc003bhh.2	-	1	3990	c.3990G>C	c.(3988-3990)CAG>CAC	p.Q1330H		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1330	Cytoplasmic (Potential).|PLAT.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AAAGCCATTTCTGGCATATGA	0.418													0	0	0	0.01441	0	51	83										G	46655230	C	G	46655230	3	3	126	1	0	0	0	0	1	0	0	0	11970	912	32	1	2775	1	PKDREJ	22	46655230	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	684784	46655230	4649336	539	37837										
ZBED4	9889	broad.mit.edu	37	chr22	50277651	50277651	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttccagccggaacatgagctCcaggaagaagtctccagcct	10	13	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:50277651C>A	uc003bix.2	+	2	811	c.341C>A	c.(340-342)TCC>TAC	p.S114Y		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	114						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AACATGAGCTCCAGGAAGAAG	0.532													1	0	9.39395e-14	0.00632	1.28991e-13	26	67										A	50277651	C	A	50277651	3	1	126	1	0	0	0	0	1	0	0	0	17517	855	30	3	343	3	ZBED4	22	50277651	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	3622421	50277651	1026915	540	37838										
PLXNB2	23654	broad.mit.edu	37	chr22	50722117	50722117	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	atgtcccctgcttggacgccCaaattggaccccaggatggt	11	13	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:50722117C>A	uc003bkv.3	-	15	2590	c.2484G>T	c.(2482-2484)TTG>TTT	p.L828F	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	828	Extracellular (Potential).|IPT/TIG 1.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTTGGACGCCCAAATTGGACC	0.647													1	0	3.07112e-06	0.010729	4.04274e-06	12	34										A	50722117	C	A	50722117	3	1	126	1	0	0	0	0	1	0	0	0	12124	593	21	4	3124	4	PLXNB2	22	50722117	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	444466	50722117	582449	541	37839										
ODF3B	440836	broad.mit.edu	37	chr22	50969699	50969699	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcactggggtacgtcgcgttCcccgctcgctccgggaagta	14	14	0	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chr22:50969699C>G	uc003bmh.2	-	4	476	c.339G>C	c.(337-339)GGG>GGC	p.G113G	TYMP_uc003bmb.3_5'Flank|TYMP_uc003bmc.3_5'Flank|TYMP_uc003bmd.3_5'Flank|TYMP_uc010hbd.2_5'Flank|TYMP_uc003bme.3_5'Flank|TYMP_uc003bmf.3_5'Flank|TYMP_uc011arz.1_5'Flank|ODF3B_uc003bmg.2_Missense_Mutation_p.E90Q	NM_001014440	NP_001014440	A8MYP8	ODF3B_HUMAN	outer dense fiber of sperm tails 3B	113											0						ACGTCGCGTTCCCCGCTCGCT	0.677													0	0	0	0.016723	0	12	40										G	50969699	C	G	50969699	2	3	126	1	0	0	0	0	0	0	0	1	10830	842	30	1		1	ODF3B	22	50969699	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	247582	50969699	334867	542	37840										
SHROOM2	357	broad.mit.edu	37	chrX	9864156	9864156	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcaggcctggcccagccaccCtcatctacaagtggcgggcc	12	17	2	0			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:9864156C>G	uc004csu.1	+	4	2298	c.2208C>G	c.(2206-2208)CCC>CCG	p.P736P		NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	736	ASD1.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CCCAGCCACCCTCATCTACAA	0.622													0	0	0	0.008291	0	9	9										G	9864156	C	G	9864156	2	3	126	1	0	0	0	0	0	0	0	1	14294	668	24	4		4	SHROOM2	23	9864156	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08		9864156	145406404	543	37841										
GEMIN8	54960	broad.mit.edu	37	chrX	14038306	14038306	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gcatctgactcagtctccatCtcttcctctttggacaaagc	6	14	5	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:14038306C>G	uc004cwb.2	-	4	706	c.363G>C	c.(361-363)GAG>GAC	p.E121D	GEMIN8_uc004cwc.2_Missense_Mutation_p.E121D|GEMIN8_uc004cwd.2_Missense_Mutation_p.E121D	NM_017856	NP_060326	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	121					spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0						CAGTCTCCATCTCTTCCTCTT	0.483													0	0	0	0.01441	0	115	24										G	14038306	C	G	14038306	3	3	126	1	0	0	0	0	1	0	0	0	6334	912	32	1	373	1	GEMIN8	23	14038306	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4174150	14038306	141232254	544	37842										
GPR64	10149	broad.mit.edu	37	chrX	19021018	19021018	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	tcggatgtaagtattaaataCtttgacaagggccaggtaca	10	6	0	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:19021018C>A	uc004cyx.2	-	24	2340	c.2176G>T	c.(2176-2178)GTA>TTA	p.V726L	GPR64_uc004cyy.2_Missense_Mutation_p.V723L|GPR64_uc004cyz.2_Missense_Mutation_p.V712L|GPR64_uc004czb.2_Missense_Mutation_p.V726L|GPR64_uc004czc.2_Missense_Mutation_p.V710L|GPR64_uc004czd.2_Missense_Mutation_p.V702L|GPR64_uc004cze.2_Missense_Mutation_p.V696L|GPR64_uc004czf.2_Missense_Mutation_p.V688L|GPR64_uc004cza.2_Missense_Mutation_p.V704L|GPR64_uc004cyw.2_Missense_Mutation_p.V710L|GPR64_uc010nfj.2_Missense_Mutation_p.V607L	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	726	Cytoplasmic (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					GTATTAAATACTTTGACAAGG	0.418													1	0	8.24728e-16	0.004656	1.14003e-15	25	33										A	19021018	C	A	19021018	3	1	126	1	0	0	0	0	1	0	0	0	6705	565	20	4	901	4	GPR64	23	19021018	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	4982712	19021018	136249542	545	37843										
DMD	1756	broad.mit.edu	37	chrX	32429985	32429985	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	taaggatttttcagtctcctGggcagactggatgctctgtt	11	8	3	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:32429985G>T	uc004dda.1	-	30	4361	c.4117C>A	c.(4117-4119)CAG>AAG	p.Q1373K	DMD_uc004dcw.2_Missense_Mutation_p.Q29K|DMD_uc004dcx.2_Missense_Mutation_p.Q32K|DMD_uc004dcz.2_Missense_Mutation_p.Q1250K|DMD_uc004dcy.1_Missense_Mutation_p.Q1369K|DMD_uc004ddb.1_Missense_Mutation_p.Q1365K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1373					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCAGTCTCCTGGGCAGACTGG	0.418													1	0	5.18039e-06	0.00308	6.79772e-06	7	8										T	32429985	G	T	32429985	3	4	126	1	0	0	0	0	1	0	0	0	4580	1357	47	4	7288	4	DMD	23	32429985	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	13408967	32429985	122840575	546	37844										
EDA2R	60401	broad.mit.edu	37	chrX	65824270	65824270	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	actgggtacacacattgaacCtcagaggtgggggtctgctt	13	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:65824270C>T	uc004dwq.2	-	3	356	c.345G>A	c.(343-345)GAG>GAA	p.E115E	EDA2R_uc004dwr.2_Silent_p.E115E|EDA2R_uc004dws.2_Silent_p.E115E|EDA2R_uc011mpb.1_RNA|EDA2R_uc011mpc.1_Intron|EDA2R_uc010nkt.1_Silent_p.E115E|EDA2R_uc004dwt.1_Silent_p.E115E	NM_021783	NP_068555	Q9HAV5	TNR27_HUMAN	X-linked ectodysplasin receptor	115	TNFR-Cys 3.|Extracellular (Potential).				cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			upper_aerodigestive_tract(1)	1						CACATTGAACCTCAGAGGTGG	0.512													0	0	0	0.020292	0	13	28										T	65824270	C	T	65824270	2	4	126	1	0	0	0	0	0	0	0	1	4904	680	24	2		2	EDA2R	23	65824270	Silent	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	33394285	65824270	89446290	547	37845										
PGAM4	441531	broad.mit.edu	37	chrX	77224638	77224638	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ggaactatttcttcattccaGaagggcagagctctggcaat	10	9	3	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:77224638G>A	uc004ecy.1	-	1	498	c.498C>T	c.(496-498)TTC>TTT	p.F166F	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	166					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CTTCATTCCAGAAGGGCAGAG	0.517													0	0	0	0.011902	0	43	53										A	77224638	G	A	77224638	2	1	126	1	0	0	0	0	0	0	0	1	11775	933	33	1		1	PGAM4	23	77224638	Silent	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	11400368	77224638	78045922	548	37846										
CENPI	2491	broad.mit.edu	37	chrX	100382569	100382569	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	aaaaaaagagatgagtctttCtgattgtctgaatagaagtg	10	3	3	5			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:100382569C>G	uc004egx.2	+	10	1259	c.989C>G	c.(988-990)TCT>TGT	p.S330C	CENPI_uc011mrg.1_Missense_Mutation_p.S330C|CENPI_uc004egy.2_Missense_Mutation_p.S330C	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	330					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						ATGAGTCTTTCTGATTGTCTG	0.378													0	0	0	0.014758	0	5	50										G	100382569	C	G	100382569	3	3	126	1	0	0	0	0	1	0	0	0	3233	913	32	1	1023	1	CENPI	23	100382569	Missense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	23157931	100382569	54887991	549	37847										
CXorf57	55086	broad.mit.edu	37	chrX	105882904	105882904	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	gactgaaagtgcctcagcatCagaaacacttcgggtatggt	11	9	2	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:105882904C>A	uc004emi.3	+	9	1872	c.1721C>A	c.(1720-1722)TCA>TAA	p.S574*	CXorf57_uc004emj.3_Intron	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	574										ovary(1)|lung(1)|breast(1)	3						GCCTCAGCATCAGAAACACTT	0.398													1	0	7.41877e-09	0.012319	9.92366e-09	21	37										A	105882904	C	A	105882904	4	1	126	1	0	0	0	0	0	1	0	0	4113	838	29	3	1755	3	CXorf57	23	105882904	Nonsense_Mutation	SNP	C	TCGA-H4-A2HQ-01A-11D-A17V-08	5500335	105882904	49387656	550	37848										
PLS3	5358	broad.mit.edu	37	chrX	114869355	114869355	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acattgaattaagcaggaatGaaggtaatggaacacagtca	10	5	1	2			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:114869355G>C	uc004eqd.2	+	7	1135	c.745G>C	c.(745-747)GAA>CAA	p.E249Q	PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Missense_Mutation_p.E227Q|PLS3_uc004eqe.2_Missense_Mutation_p.E249Q|PLS3_uc011mtg.1_Missense_Mutation_p.E222Q|PLS3_uc011mth.1_Missense_Mutation_p.E204Q	NM_005032	NP_005023	P13797	PLST_HUMAN	plastin 3	249	Actin-binding 1.					cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2						AAGCAGGAATGAAGGTAATGG	0.408													0	0	0	0.007291	0	26	51										C	114869355	G	C	114869355	3	2	126	1	0	0	0	0	1	0	0	0	12108	1291	45	1	767	1	PLS3	23	114869355	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	8986451	114869355	40401205	551	37849										
STAG2	10735	broad.mit.edu	37	chrX	123189994	123189994	+	Frame_Shift_Del	DEL	C	C	-													0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	ttaggagtagtgaagaagttCtcactgcagaagattgtgaa							TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:123189994delC	uc004etz.3	+	13	1552	c.1213delC	c.(1213-1215)CTCfs	p.L405fs	STAG2_uc004eua.2_Frame_Shift_Del_p.L405fs|STAG2_uc004eub.2_Frame_Shift_Del_p.L405fs|STAG2_uc004euc.2_Frame_Shift_Del_p.L405fs|STAG2_uc004eud.2_Frame_Shift_Del_p.L405fs|STAG2_uc004eue.2_Frame_Shift_Del_p.L405fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	405					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGAAGAAGTTCTCACTGCAGA	0.363																		57	21	---	---								-	123189994	C	-	123189994	7	5	126	1	0	1	0	1	0	0	0	0	15242	913	32	0	1259	0	STAG2	23	123189994	Frame_Shift_Del	DEL	C	TCGA-H4-A2HQ-01A-11D-A17V-08	8320639	123189994	32080566	552	37850										
MAGEC3	139081	broad.mit.edu	37	chrX	140985120	140985120	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	acaaccactcctatttctttGaagacacattagacctcacc	3	14	2	3			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:140985120G>A	uc011mwp.1	+	7	1576	c.1576G>A	c.(1576-1578)GAA>AAA	p.E526K	MAGEC3_uc004fbs.2_Missense_Mutation_p.E228K|MAGEC3_uc010nsj.2_Missense_Mutation_p.E228K	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	526	MAGE 2.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTATTTCTTTGAAGACACATT	0.438													0	0	0	0.01441	0	52	99										A	140985120	G	A	140985120	3	1	126	1	0	0	0	0	1	0	0	0	9182	1291	45	1	1831	1	MAGEC3	23	140985120	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	17795126	140985120	14285440	553	37851										
MTM1	4534	broad.mit.edu	37	chrX	149767125	149767125	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.392727272727273	216	1.70615309351e-76	3.89120549120549	4.65252830470222	3.32635308119179	0.783524973584344	0.870583303982605	160	agtttacatcacaaattatcGtctttatttaagaagtttgg	6	5	2	1			TCGA-H4-A2HQ-01A-11D-A17V-08	TCGA-H4-A2HQ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94108975-b7a0-40ba-ad39-e44cc62e8cc0	2a00d649-7f80-467d-849d-1383cceec965	g.chrX:149767125G>A	uc004fef.3	+	4	282	c.206G>A	c.(205-207)CGT>CAT	p.R69H	MTM1_uc011mxx.1_Intron|MTM1_uc011mxy.1_Missense_Mutation_p.R69H|MTM1_uc011mxz.1_Intron|MTM1_uc010nte.2_5'UTR	NM_000252	NP_000243	Q13496	MTM1_HUMAN	myotubularin	69	GRAM.		R -> P (in XCNM).|R -> C (in XCNM; mild; reduced response to PI5P and reduced binding to PI(3,5)P2).|R -> S (in XCNM; severe).		endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACAAATTATCGTCTTTATTTA	0.299													0	0	0	0.004482	0	8	13										A	149767125	G	A	149767125	3	1	126	1	0	0	0	0	1	0	0	0	9937	1145	40	2	216	2	MTM1	23	149767125	Missense_Mutation	SNP	G	TCGA-H4-A2HQ-01A-11D-A17V-08	8782005	149767125	5503435	554	37852										
DCDC2B	149069	broad.mit.edu	37	chr1	32678173	32678173	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atgtggctgtcggagaggatGagttcaaggaccttccctat	13	8	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:32678173G>A	uc001bun.2	+	5	610	c.610G>A	c.(610-612)GAG>AAG	p.E204K		NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	204	Doublecortin 2.				intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CGGAGAGGATGAGTTCAAGGA	0.612													0	0	0	0.009535	0	33	85										A	32678173	G	A	32678173	3	1	127	1	0	0	0	0	1	0	0	0	4286	1291	45	1	628	1	DCDC2B	1	32678173	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		32678173	216572448	1	37853										
HPCA	3208	broad.mit.edu	37	chr1	33354707	33354707	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agtttgccgagcacgtcttcCgcacctttgacaccaacagc	8	15	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:33354707C>T	uc001bwh.2	+	2	248	c.208C>T	c.(208-210)CGC>TGC	p.R70C		NM_002143	NP_002134	P84074	HPCA_HUMAN	hippocalcin	70	EF-hand 2.						actin binding|calcium ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GCACGTCTTCCGCACCTTTGA	0.557													0	0	0	0.009718	0	37	119										T	33354707	C	T	33354707	3	4	127	1	0	0	0	0	1	0	0	0	7329	652	23	2	210	2	HPCA	1	33354707	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	676534	33354707	215895914	2	37854										
MACF1	23499	broad.mit.edu	37	chr1	39851577	39851577	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggagacagttgccctgcctCtccaaggtttagaagacctt	10	11	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:39851577C>T	uc010oiu.1	+	21	9771	c.9640C>T	c.(9640-9642)CTC>TTC	p.L3214F	MACF1_uc010ois.1_Missense_Mutation_p.L2712F|MACF1_uc001cda.1_Missense_Mutation_p.L2599F|MACF1_uc001cdc.1_Missense_Mutation_p.L1778F	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4779	LRR 18.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGCCCTGCCTCTCCAAGGTTT	0.483													0	0	0	0.00632	0	24	54										T	39851577	C	T	39851577	3	4	127	1	0	0	0	0	1	0	0	0	9144	913	32	1	14491	1	MACF1	1	39851577	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	6496870	39851577	209399044	3	37855										
GLIS1	148979	broad.mit.edu	37	chr1	54060263	54060263	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tcccgtcagaggggggctccGgagtccatttacacaggtga	14	11	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:54060263G>A	uc001cvr.1	-	3	880	c.313C>T	c.(313-315)CGG>TGG	p.R105W		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	105					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						GGGGGGCTCCGGAGTCCATTT	0.662													0	0	0	0.010729	0	9	33										A	54060263	G	A	54060263	3	1	127	1	0	0	0	0	1	0	0	0	6445	1115	39	2	1581	2	GLIS1	1	54060263	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	14208686	54060263	195190358	4	37856										
LRRIQ3	127255	broad.mit.edu	37	chr1	74507362	74507362	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgtcaatatcactaaatgttCggagtttcataccagctctt	6	9	4	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:74507362C>T	uc001dfy.3	-	7	1445	c.1253G>A	c.(1252-1254)CGA>CAA	p.R418Q	LRRIQ3_uc001dfz.3_Intron	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	418										ovary(2)	2						ACTAAATGTTCGGAGTTTCAT	0.363													0	0	0	0.013537	0	13	30										T	74507362	C	T	74507362	3	4	127	1	0	0	0	0	1	0	0	0	9030	884	31	1	629	1	LRRIQ3	1	74507362	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	20447099	74507362	174743259	5	37857										
LPHN2	23266	broad.mit.edu	37	chr1	82436188	82436188	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggttggagtttcagctgctaTtgactataagagctatggaa	12	5	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:82436188T>C	uc001dit.3	+	15	3054	c.2873T>C	c.(2872-2874)ATT>ACT	p.I958T	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.I958T|LPHN2_uc001div.2_Missense_Mutation_p.I958T|LPHN2_uc009wcd.2_Missense_Mutation_p.I958T|LPHN2_uc001diw.2_Missense_Mutation_p.I542T|LPHN2_uc009wce.1_Missense_Mutation_p.I44T	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	971	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TCAGCTGCTATTGACTATAAG	0.353													0	0	0	0.010729	0	11	35										C	82436188	T	C	82436188	3	2	127	1	0	0	0	0	1	0	0	0	8916	1493	52	5	2923	5	LPHN2	1	82436188	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	7928826	82436188	166814433	6	37858										
CELSR2	1952	broad.mit.edu	37	chr1	109806339	109806339	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agcctcatgttccgcacgcgCcaggccgacggtgtcctgct	12	16	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:109806339C>T	uc001dxa.3	+	9	5002	c.4941C>T	c.(4939-4941)CGC>CGT	p.R1647R		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1647	Extracellular (Potential).|Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TCCGCACGCGCCAGGCCGACG	0.667											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00874	0	39	104										T	109806339	C	T	109806339	2	4	127	1	0	0	0	0	0	0	0	1	3222	726	26	2		2	CELSR2	1	109806339	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	27370151	109806339	139444282	7	37859										
C1orf183	55924	broad.mit.edu	37	chr1	112269937	112269937	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttcacgtgcccccccagtctCacccttctccccacccttct	3	23	4	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:112269937C>G	uc001ebo.1	-	2	705	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	C1orf183_uc001ebp.1_Missense_Mutation_p.E168Q	NM_019099	NP_061972	Q9NTI7	CA183_HUMAN	hypothetical protein LOC55924 isoform 1	183										ovary(2)	2		all_cancers(81;7.29e-06)|all_epithelial(167;4.98e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.16e-05)		Lung(183;0.0155)|Colorectal(144;0.0289)|all cancers(265;0.0592)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0852)|COAD - Colon adenocarcinoma(174;0.113)		CCCCCAGTCTCACCCTTCTCC	0.577													0	0	0	0.01441	0	68	53										G	112269937	C	G	112269937	3	3	127	1	0	0	0	0	1	0	0	0	2019	835	29	1	350	1	C1orf183	1	112269937	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	2463598	112269937	136980684	8	37860										
PDE4DIP	9659	broad.mit.edu	37	chr1	144923816	144923816	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgtttcagcaactcttcagtCatgggctaggaagaaacggc	11	9	4	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:144923816C>A	uc001elw.3	-	6	933	c.642G>T	c.(640-642)ATG>ATT	p.M214I	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.M280I|PDE4DIP_uc001emc.1_Missense_Mutation_p.M214I|PDE4DIP_uc001emd.1_Missense_Mutation_p.M214I|PDE4DIP_uc001emb.1_Missense_Mutation_p.M377I|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.M1I	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	214					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACTCTTCAGTCATGGGCTAGG	0.398			T	PDGFRB	MPD								1	0	1.15919e-05	0.008871	1.20509e-05	20	191										A	144923816	C	A	144923816	3	1	127	1	0	0	0	0	1	0	0	0	11643	826	29	3	6564	3	PDE4DIP	1	144923816	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	32653879	144923816	104326805	9	37861										
ZNF687	57592	broad.mit.edu	37	chr1	151260360	151260360	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gggctggccctgcctcccacCggctaccgctgcctggagtg	14	17	0	0	rs142842127	byFrequency	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:151260360C>T	uc001exq.2	+	2	1691	c.1593C>T	c.(1591-1593)ACC>ACT	p.T531T	ZNF687_uc001exp.1_Silent_p.T540T|ZNF687_uc009wmo.2_Silent_p.T531T|ZNF687_uc009wmp.2_Silent_p.T531T	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	531					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCCTCCCACCGGCTACCGCT	0.617													0	0	0	0.003163	0	15	76										T	151260360	C	T	151260360	2	4	127	1	0	0	0	0	0	0	0	1	18089	639	23	2		2	ZNF687	1	151260360	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	6336544	151260360	97990261	10	37862										
RHBG	57127	broad.mit.edu	37	chr1	156339062	156339073	+	In_Frame_Del	DEL	GCCGCGGGCCGG	GCCGCGGGCCGG	-													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggccgggtctcctagccgcGccgcgggccggcgactgcag							TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:156339062_156339073delGCCGCGGGCCGG	uc010pho.1	+	1	60_71	c.22_33delGCCGCGGGCCGG	c.(22-33)GCCGCGGGCCGGdel	p.AAGR8del	RHBG_uc010phm.1_In_Frame_Del_p.AAGR8del|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_5'UTR|RHBG_uc009wrz.2_5'UTR|RHBG_uc001for.2_5'UTR	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	8_11	Cytoplasmic (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					TCCTAGCCGCGCCGCGGGCCGGCGACTGCAGC	0.67																		16	90	---	---								-	156339073	GCCGCGGGCCGG	-	156339062	7	5	127	1	0	1	0	1	0	0	0	0	13324	1087	38	0	24	0	RHBG	1	156339062	In_Frame_Del	DEL	GCCGCGGGCCGG	TCGA-HQ-A2OE-01A-11D-A202-08	5078702	156339062	92911559	11	37863										
APCS	325	broad.mit.edu	37	chr1	159557901	159557901	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tatcccgcagacctcagtggGaaggtgtttgtatttcctag	11	9	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:159557901G>C	uc001ftv.2	+	2	171	c.75G>C	c.(73-75)GGG>GGC	p.G25G		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	25	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					ACCTCAGTGGGAAGGTGTTTG	0.393													0	0	0	0.013537	0	11	49										C	159557901	G	C	159557901	2	2	127	1	0	0	0	0	0	0	0	1	767	1161	41	1		1	APCS	1	159557901	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	3218839	159557901	89692720	12	37864										
PVRL4	81607	broad.mit.edu	37	chr1	161046208	161046208	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	acttgagcatagctccttctCtgccaatgtgccacagattt	7	12	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:161046208C>G	uc001fxo.2	-	4	1087	c.788G>C	c.(787-789)AGA>ACA	p.R263T	PVRL4_uc010pjy.1_5'Flank|PVRL4_uc010pjz.1_5'UTR	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	263	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			AGCTCCTTCTCTGCCAATGTG	0.552													0	0	0	0.00874	0	44	66										G	161046208	C	G	161046208	3	3	127	1	0	0	0	0	1	0	0	0	12842	913	32	1	768	1	PVRL4	1	161046208	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	1488307	161046208	88204413	13	37865										
FCGR2A	2212	broad.mit.edu	37	chr1	161480706	161480706	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtagcagccattgttgctgcTgtagtggccttgatctactg	12	9	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:161480706T>A	uc001gan.2	+	5	755	c.702T>A	c.(700-702)GCT>GCA	p.A234A	FCGR2A_uc001gam.2_Silent_p.A233A|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	234	Helical; (Potential).					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TTGTTGCTGCTGTAGTGGCCT	0.517													0	0	0	0.01441	0	47	225										A	161480706	T	A	161480706	2	1	127	1	0	0	0	0	0	0	0	1	5781	1567	55	5		5	FCGR2A	1	161480706	Silent	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	434498	161480706	87769915	14	37866										
GORAB	92344	broad.mit.edu	37	chr1	170511708	170511708	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaaataaacgtaaaaaagctCttttggctaaagctattgca	6	6	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:170511708C>G	uc001gha.2	+	3	598	c.571C>G	c.(571-573)CTT>GTT	p.L191V	GORAB_uc001ggz.3_Missense_Mutation_p.L191V|GORAB_uc009wvx.2_Missense_Mutation_p.L11V|GORAB_uc001ghb.2_Missense_Mutation_p.L11V|GORAB_uc001ghc.2_Missense_Mutation_p.L11V|GORAB_uc001ghd.2_5'Flank	NM_152281	NP_689494	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting isoform a	191	Potential.					Golgi apparatus|nucleus					0						TAAAAAAGCTCTTTTGGCTAA	0.403													0	0	0	0.014323	0	20	89										G	170511708	C	G	170511708	3	3	127	1	0	0	0	0	1	0	0	0	6574	913	32	1	581	1	GORAB	1	170511708	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	9031002	170511708	78738913	15	37867										
IVNS1ABP	10625	broad.mit.edu	37	chr1	185269586	185269586	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	taccatgagtacagccatttGaaatcgggctcttggtgttc	10	9	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:185269586G>C	uc001grl.2	-	11	1848	c.1225C>G	c.(1225-1227)CAA>GAA	p.Q409E	IVNS1ABP_uc001gri.2_Missense_Mutation_p.Q69E|IVNS1ABP_uc001grj.2_Missense_Mutation_p.Q69E|IVNS1ABP_uc009wyj.2_Missense_Mutation_p.Q191E|IVNS1ABP_uc009wyk.2_RNA|IVNS1ABP_uc001grm.2_Missense_Mutation_p.Q69E	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	409	Kelch 1.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ACAGCCATTTGAAATCGGGCT	0.428													0	0	0	0.000602	0	5	29										C	185269586	G	C	185269586	3	2	127	1	0	0	0	0	1	0	0	0	7930	1299	45	1	723	1	IVNS1ABP	1	185269586	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	14757878	185269586	63981035	16	37868										
IL19	29949	broad.mit.edu	37	chr1	207014389	207014389	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctgcaggcaggaagccaccaAtgccaccagagtcatccatg	10	14	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:207014389A>T	uc001hep.2	+	6	1343	c.404A>T	c.(403-405)AAT>ATT	p.N135I	IL19_uc001heo.2_Missense_Mutation_p.N173I	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	135					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			GAAGCCACCAATGCCACCAGA	0.517													0	0	0	0.013537	0	13	27										T	207014389	A	T	207014389	3	4	127	1	0	0	0	0	1	0	0	0	7649	101	4	5	536	5	IL19	1	207014389	Missense_Mutation	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08	21744803	207014389	42236232	17	37869										
CEP170	9859	broad.mit.edu	37	chr1	243328008	243328008	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gggtggttgatttactagatGaaccagataccaccggagaa	12	7	0	5			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:243328008G>A	uc001hzs.2	-	13	3662	c.3254C>T	c.(3253-3255)TCA>TTA	p.S1085L	CEP170_uc001hzt.2_Missense_Mutation_p.S987L|CEP170_uc001hzu.2_Missense_Mutation_p.S987L|CEP170_uc001hzv.1_Missense_Mutation_p.S463L	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	1085	Targeting to microtubules.					centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTTACTAGATGAACCAGATAC	0.483													0	0	0	0.001168	0	4	34										A	243328008	G	A	243328008	3	1	127	1	0	0	0	0	1	0	0	0	3250	1294	45	1	1562	1	CEP170	1	243328008	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	36313619	243328008	5922613	18	37870										
OR2M7	391196	broad.mit.edu	37	chr1	248487560	248487560	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cggagccaagcaatgatataTagaagaaaatttgtgtggca	11	5	0	3	rs41304034		TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr1:248487560T>C	uc010pzk.1	-	1	311	c.311A>G	c.(310-312)TAT>TGT	p.Y104C		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAATGATATATAGAAGAAAAT	0.458													0	0	0	0.01441	0	62	74										C	248487560	T	C	248487560	3	2	127	1	0	0	0	0	1	0	0	0	11014	1406	49	5	630	5	OR2M7	1	248487560	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	5159552	248487560	763061	19	37871										
SRBD1	55133	broad.mit.edu	37	chr2	45789849	45789849	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctccatcagaaatattgaccTtaaccgtcagtaccttcaaa	4	12	3	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:45789849T>A	uc002rus.2	-	10	1428	c.1352A>T	c.(1351-1353)AAG>ATG	p.K451M	SRBD1_uc010yoc.1_Translation_Start_Site	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	451					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AATATTGACCTTAACCGTCAG	0.343													0	0	0	0.00499	0	16	85										A	45789849	T	A	45789849	3	1	127	1	0	0	0	0	1	0	0	0	15132	1609	56	5	1683	5	SRBD1	2	45789849	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08		45789849	197409524	20	37872										
FAM123C	205147	broad.mit.edu	37	chr2	131520501	131520501	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggagagcaaggttcccaggGgccctctccagggcagtgtg	16	11	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:131520501G>A	uc002trw.2	+	2	1046	c.856G>A	c.(856-858)GGC>AGC	p.G286S	FAM123C_uc010fmv.2_Missense_Mutation_p.G286S|FAM123C_uc010fms.1_Missense_Mutation_p.G286S|FAM123C_uc010fmt.1_Missense_Mutation_p.G286S|FAM123C_uc010fmu.1_Missense_Mutation_p.G286S	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	286										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GGTTCCCAGGGGCCCTCTCCA	0.637													0	0	0	0.001855	0	13	40										A	131520501	G	A	131520501	3	1	127	1	0	0	0	0	1	0	0	0	5424	1232	43	2	858	2	FAM123C	2	131520501	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	85730652	131520501	111678872	21	37873										
PDE11A	50940	broad.mit.edu	37	chr2	178936789	178936789	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtggatggccttggagcgggCaaaactcttccttagctctt	12	10	2	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:178936789C>G	uc002ulq.2	-	1	694	c.376G>C	c.(376-378)GCC>CCC	p.A126P	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	126					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTGGAGCGGGCAAAACTCTTC	0.612									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	0.000602	0	4	79										G	178936789	C	G	178936789	3	3	127	1	0	0	0	0	1	0	0	0	11631	710	25	4	2505	4	PDE11A	2	178936789	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	47416288	178936789	64262584	22	37874										
TTN	7273	broad.mit.edu	37	chr2	179457374	179457374	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gccatgttggcatcaagaatCaactcagggggttctagaat	11	8	4	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:179457374C>T	uc010zfg.1	-	250	51878	c.51654G>A	c.(51652-51654)TTG>TTA	p.L17218L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L10913L|TTN_uc010zfi.1_Silent_p.L10846L|TTN_uc010zfj.1_Silent_p.L10721L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18145							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCAAGAATCAACTCAGGGG	0.373													0	0	0	0.001168	0	6	8										T	179457374	C	T	179457374	2	4	127	1	0	0	0	0	0	0	0	1	16732	825	29	1		1	TTN	2	179457374	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	520585	179457374	63741999	23	37875										
ZNF804A	91752	broad.mit.edu	37	chr2	185803315	185803315	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccaaacatgctggccaacaaGgttaaatttacctttcctcc	5	13	0	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:185803315G>A	uc002uph.2	+	4	3786	c.3192G>A	c.(3190-3192)AAG>AAA	p.K1064K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1064						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGGCCAACAAGGTTAAATTTA	0.468													0	0	0	0.004007	0	16	31										A	185803315	G	A	185803315	2	1	127	1	0	0	0	0	0	0	0	1	18167	991	35	2		2	ZNF804A	2	185803315	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	6345941	185803315	57396058	24	37876										
ESPNL	339768	broad.mit.edu	37	chr2	239013413	239013413	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggcgctgacgtgcaccttcGtgctctcgatggcatgagcg	14	12	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:239013413G>C	uc002vxq.3	+	3	712	c.602G>C	c.(601-603)CGT>CCT	p.R201P		NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	201										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GTGCACCTTCGTGCTCTCGAT	0.677													0	0	0	0.001984	0	7	7										C	239013413	G	C	239013413	3	2	127	1	0	0	0	0	1	0	0	0	5255	1145	40	4	612	4	ESPNL	2	239013413	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	53210098	239013413	4185960	25	37877										
PASK	23178	broad.mit.edu	37	chr2	242046892	242046892	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tcagggactggctgcagcagCccagacacaaggctcatgag	13	12	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr2:242046892C>T	uc002wao.1	-	17	3782	c.3690G>A	c.(3688-3690)GGG>GGA	p.G1230G	PASK_uc010zol.1_Silent_p.G1044G|PASK_uc010zom.1_Silent_p.G1195G|PASK_uc010fzl.1_Silent_p.G1237G|PASK_uc010zon.1_Silent_p.G1011G	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	1230	Protein kinase.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCTGCAGCAGCCCAGACACAA	0.542													0	0	0	0.004656	0	25	54										T	242046892	C	T	242046892	2	4	127	1	0	0	0	0	0	0	0	1	11472	726	26	2		2	PASK	2	242046892	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	3033479	242046892	1152481	26	37878										
BRPF1	7862	broad.mit.edu	37	chr3	9781381	9781381	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gcgggagacaggcgccaacgGcacctctttcagtgtccgca	13	14	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:9781381G>A	uc003bse.2	+	3	1697	c.1298G>A	c.(1297-1299)GGC>GAC	p.G433D	BRPF1_uc003bsf.2_Missense_Mutation_p.G433D|BRPF1_uc003bsg.2_Missense_Mutation_p.G433D|BRPF1_uc011ati.1_Missense_Mutation_p.G433D	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	433					histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GGCGCCAACGGCACCTCTTTC	0.567													0	0	0	0.000602	0	5	42										A	9781381	G	A	9781381	3	1	127	1	0	0	0	0	1	0	0	0	1520	1203	42	2	1304	2	BRPF1	3	9781381	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		9781381	188241049	27	37879										
PLCL2	23228	broad.mit.edu	37	chr3	17052785	17052785	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgggaagtctgttcctttaaTgaagtgcttgccagcaagta	11	7	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:17052785T>C	uc011awc.1	+	5	2028	c.1923T>C	c.(1921-1923)AAT>AAC	p.N641N	PLCL2_uc011awd.1_Silent_p.N523N	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	649	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GTTCCTTTAATGAAGTGCTTG	0.413													0	0	0	0.00245	0	11	54										C	17052785	T	C	17052785	2	2	127	1	0	0	0	0	0	0	0	1	12040	1461	51	5		5	PLCL2	3	17052785	Silent	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	7271404	17052785	180969645	28	37880										
CTNNB1	1499	broad.mit.edu	37	chr3	41266097	41266097	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggcagcaacagtcttacctgGactctggaatccattctggt	10	11	3	0	rs28931588		TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:41266097G>C	uc010hia.1	+	4	250	c.94G>C	c.(94-96)GAC>CAC	p.D32H	CTNNB1_uc003ckp.2_Missense_Mutation_p.D32H|CTNNB1_uc003ckq.2_Missense_Mutation_p.D32H|CTNNB1_uc003ckr.2_Missense_Mutation_p.D32H|CTNNB1_uc011azf.1_Missense_Mutation_p.D25H|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	32			Missing (in hepatocellular carcinoma).|D -> A (in hepatocellular carcinoma).|D -> G (in PTR and hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.D32Y(110)|p.A5_A80del(63)|p.D32N(58)|p.D32G(53)|p.D32H(37)|p.D32V(20)|p.D32A(12)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.WQQQSYLD25?(5)|p.Q28_H134del(5)|p.W25_D32del(4)|p.W25_I140del(4)|p.S23_S33del(3)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32E(2)|p.D32_S47del(2)|p.W25_H36del(2)|p.Y30_S33del(2)|p.V22_S33del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S29_H36del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.W25_I35del(1)|p.V22_G80>NNNNN(1)|p.A5_I35del(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.D32del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.W25_S33del(1)|p.V22_T102del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.D32_H36>D(1)|p.P16_K133del(1)|p.A5_T59del(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.V22_Y64del(1)|p.M8_A80del(1)|p.E9_I140del(1)|p.D32_S33insS(1)|p.Y30_T40del(1)|p.M1_T42del(1)|p.A5_Q143>E(1)|p.A5_Q72del(1)|p.Q28_D32>H(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.S23_I35del(1)|p.V22_S71>A(1)|p.W25_A80del(1)|p.A20_Q72del(1)|p.A20_S111del(1)|p.D32_H36del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GTCTTACCTGGACTCTGGAAT	0.478	D32N(KE39_STOMACH)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.001168	0	5	26										C	41266097	G	C	41266097	3	2	127	1	0	0	0	0	1	0	0	0	4016	1174	41	1	100	1	CTNNB1	3	41266097	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	24213312	41266097	156756333	29	37881										
NKTR	4820	broad.mit.edu	37	chr3	42678866	42678866	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtccagatctagttccaagtCtgggcaccgaaagagagcat	11	10	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:42678866C>T	uc003clo.2	+	13	1817	c.1670C>T	c.(1669-1671)TCT>TTT	p.S557F	NKTR_uc003clm.1_Missense_Mutation_p.S304F|NKTR_uc003clp.2_Missense_Mutation_p.S304F|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.S447F|NKTR_uc003clr.1_Missense_Mutation_p.S304F|NKTR_uc003cls.2_Missense_Mutation_p.S257F	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	557	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AGTTCCAAGTCTGGGCACCGA	0.413													0	0	0	0.013537	0	12	57										T	42678866	C	T	42678866	3	4	127	1	0	0	0	0	1	0	0	0	10448	913	32	1	1716	1	NKTR	3	42678866	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	1412769	42678866	155343564	30	37882										
CYP8B1	1582	broad.mit.edu	37	chr3	42917227	42917227	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agggggctcccatggcctgcGttgtcggagcatccctggca	15	13	0	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:42917227G>A	uc003cmh.2	-	1	407	c.82C>T	c.(82-84)CGC>TGC	p.R28C	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Missense_Mutation_p.R28C	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	28					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CATGGCCTGCGTTGTCGGAGC	0.582													0	0	0	0.006214	0	9	64										A	42917227	G	A	42917227	3	1	127	1	0	0	0	0	1	0	0	0	4198	1145	40	2	1427	2	CYP8B1	3	42917227	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	238361	42917227	155105203	31	37883										
KIF15	56992	broad.mit.edu	37	chr3	44867652	44867652	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	acctccaaaacttcaaaaaaGaaaatgaaactctgaaatct	3	9	3	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:44867652G>C	uc003cnx.3	+	21	2820	c.2671G>C	c.(2671-2673)GAA>CAA	p.E891Q	KIF15_uc010hiq.2_Missense_Mutation_p.E794Q|KIF15_uc010hir.2_5'UTR	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	891	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CTTCAAAAAAGAAAATGAAAC	0.259													0	0	0	0.004656	0	26	42										C	44867652	G	C	44867652	3	2	127	1	0	0	0	0	1	0	0	0	8277	943	33	1	2753	1	KIF15	3	44867652	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1950425	44867652	153154778	32	37884										
GNAT1	2779	broad.mit.edu	37	chr3	50231561	50231561	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gggcagcgctcggagcgcaaGaagtggatccactgcttcga	15	11	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:50231561G>C	uc003cym.2	+	6	731	c.615G>C	c.(613-615)AAG>AAC	p.K205N	GNAT1_uc003cyl.2_Missense_Mutation_p.K205N	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	205					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGGAGCGCAAGAAGTGGATCC	0.667													0	0	0	0.004007	0	14	16										C	50231561	G	C	50231561	3	2	127	1	0	0	0	0	1	0	0	0	6511	933	33	1	637	1	GNAT1	3	50231561	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	5363909	50231561	147790869	33	37885										
BAP1	8314	broad.mit.edu	37	chr3	52436687	52436687	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtgggtccttctctggtcatCaatctgtaggagagaagaag	13	7	4	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:52436687C>G	uc003ddx.2	-	16	2102	c.1987G>C	c.(1987-1989)GAT>CAT	p.D663H	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_RNA	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	663	Interaction with BRCA1.				monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CTCTGGTCATCAATCTGTAGG	0.527			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.012213	0	32	3										G	52436687	C	G	52436687	3	3	127	1	0	0	0	0	1	0	0	0	1311	826	29	1	210	1	BAP1	3	52436687	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	2205126	52436687	145585743	34	37886										
BAP1	8314	broad.mit.edu	37	chr3	52436810	52436810	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cccaccttgaacttcttcctCttctctacctcctccttgag	3	18	3	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:52436810C>G	uc003ddx.2	-	15	2083	c.1968G>C	c.(1966-1968)AAG>AAC	p.K656N	BAP1_uc003ddw.2_RNA|BAP1_uc010hmg.2_RNA|BAP1_uc010hmh.2_RNA	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	656	Potential.|Interaction with BRCA1.			KRKKFK->AAAAAA: Does not affect nuclear localization.	monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		ACTTCTTCCTCTTCTCTACCT	0.557			N|Mis|F|S|O		uveal melanoma|breast|NSCLC								0	0	0	0.01441	0	52	13										G	52436810	C	G	52436810	3	3	127	1	0	0	0	0	1	0	0	0	1311	912	32	1	233	1	BAP1	3	52436810	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	123	52436810	145585620	35	37887										
ADAMTS9	56999	broad.mit.edu	37	chr3	64666970	64666970	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttgttttgttcctcttcatCttcttgttcatccatagact	4	10	5	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:64666970C>T	uc003dmg.2	-	3	618	c.586G>A	c.(586-588)GAT>AAT	p.D196N	ADAMTS9_uc011bfo.1_Missense_Mutation_p.D196N|ADAMTS9_uc003dmh.1_Missense_Mutation_p.D25N|ADAMTS9_uc003dmk.1_Missense_Mutation_p.D196N	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	196					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TCCTCTTCATCTTCTTGTTCA	0.468													0	0	0	0.014323	0	24	6										T	64666970	C	T	64666970	3	4	127	1	0	0	0	0	1	0	0	0	273	913	32	1	5369	1	ADAMTS9	3	64666970	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	12230160	64666970	133355460	36	37888										
IMPG2	50939	broad.mit.edu	37	chr3	100963595	100963595	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttgaaggcaatgaatcaataGaaagaaaatcttctgactct	7	6	4	5			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:100963595G>C	uc003duq.1	-	13	1783	c.1580C>G	c.(1579-1581)TCT>TGT	p.S527C	IMPG2_uc011bhe.1_Missense_Mutation_p.S390C	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	527	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGAATCAATAGAAAGAAAATC	0.343													0	0	0	0.000602	0	5	14										C	100963595	G	C	100963595	3	2	127	1	0	0	0	0	1	0	0	0	7729	942	33	1	2173	1	IMPG2	3	100963595	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	36296625	100963595	97058835	37	37889										
MYLK	4638	broad.mit.edu	37	chr3	123383093	123383093	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gttctccaccttcatgtgctCgctttcctggatctaggggc	10	13	3	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:123383093C>A	uc003ego.2	-	23	4126	c.3844G>T	c.(3844-3846)GAG>TAG	p.E1282*	MYLK_uc010hrr.2_5'UTR|MYLK_uc011bjv.1_Nonsense_Mutation_p.E82*|MYLK_uc011bjw.1_Nonsense_Mutation_p.E1282*|MYLK_uc003egp.2_Nonsense_Mutation_p.E1213*|MYLK_uc003egq.2_Nonsense_Mutation_p.E1282*|MYLK_uc003egr.2_Nonsense_Mutation_p.E1213*|MYLK_uc003egs.2_Nonsense_Mutation_p.E1106*	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1282	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TTCATGTGCTCGCTTTCCTGG	0.617													1	0	3.85864e-22	0.00278	4.28738e-22	25	123										A	123383093	C	A	123383093	4	1	127	1	0	0	0	0	0	1	0	0	10056	893	31	3	1948	3	MYLK	3	123383093	Nonsense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	22419498	123383093	74639337	38	37890										
CDV3	55573	broad.mit.edu	37	chr3	133293897	133293897	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttacaggacgaagatgaatgGaaagaattggagcaaaaaga	12	3	0	4			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:133293897G>C	uc003epq.2	+	2	710	c.255G>C	c.(253-255)TGG>TGC	p.W85C	CDV3_uc003epp.3_Missense_Mutation_p.W85C|CDV3_uc003epr.2_5'UTR	NM_017548	NP_060018	Q9UKY7	CDV3_HUMAN	carnitine deficiency-associated gene expressed	85					cell proliferation	cytoplasm					0						AAGATGAATGGAAAGAATTGG	0.368													0	0	0	0.003954	0	23	46										C	133293897	G	C	133293897	3	2	127	1	0	0	0	0	1	0	0	0	3181	1183	41	1	261	1	CDV3	3	133293897	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	9910804	133293897	64728533	39	37891										
CDV3	55573	broad.mit.edu	37	chr3	133293922	133293922	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aattggagcaaaaagaggttGattacagcggcctcagggtt	13	6	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:133293922G>C	uc003epq.2	+	2	735	c.280G>C	c.(280-282)GAT>CAT	p.D94H	CDV3_uc003epp.3_Missense_Mutation_p.D94H|CDV3_uc003epr.2_5'UTR	NM_017548	NP_060018	Q9UKY7	CDV3_HUMAN	carnitine deficiency-associated gene expressed	94					cell proliferation	cytoplasm					0						AAAAGAGGTTGATTACAGCGG	0.358													0	0	0	0.008361	0	27	41										C	133293922	G	C	133293922	3	2	127	1	0	0	0	0	1	0	0	0	3181	1290	45	1	286	1	CDV3	3	133293922	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	25	133293922	64728508	40	37892										
HPS3	84343	broad.mit.edu	37	chr3	148847538	148847538	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agctgtacaacctgcacccgTtcgggtcgcagcaggtggtg	14	12	0	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr3:148847538T>C	uc003ewu.1	+	1	168	c.28T>C	c.(28-30)TTC>CTC	p.F10L	HPS3_uc003ewt.1_Missense_Mutation_p.F10L|HPS3_uc011bnq.1_Missense_Mutation_p.F10L	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	10						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CCTGCACCCGTTCGGGTCGCA	0.721									Hermansky-Pudlak_syndrome				0	0	0	0.006214	0	7	26										C	148847538	T	C	148847538	3	2	127	1	0	0	0	0	1	0	0	0	7340	1725	60	5	30	5	HPS3	3	148847538	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	15553616	148847538	49174892	41	37893										
PRKG2	5593	broad.mit.edu	37	chr4	82027076	82027076	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggtcatcatttggtcaacccCagaaaagggtgggctagata	12	8	3	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr4:82027076C>T	uc003hmh.2	-	15	1968	c.1954G>A	c.(1954-1956)GGG>AGG	p.G652R	PRKG2_uc011ccf.1_Missense_Mutation_p.G232R|PRKG2_uc011ccg.1_Missense_Mutation_p.G232R|PRKG2_uc011cch.1_Missense_Mutation_p.G623R	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	652	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						TGGTCAACCCCAGAAAAGGGT	0.358													0	0	0	0.001168	0	5	15										T	82027076	C	T	82027076	3	4	127	1	0	0	0	0	1	0	0	0	12523	594	21	2	350	2	PRKG2	4	82027076	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		82027076	109127200	42	37894										
COQ2	27235	broad.mit.edu	37	chr4	84193256	84193256	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tcacccaaggctagttgaggCcagtatgaaattcttttcat	8	9	3	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr4:84193256C>T	uc003hog.2	-	4	659	c.651G>A	c.(649-651)TGG>TGA	p.W217*	COQ2_uc011ccp.1_RNA|COQ2_uc003hof.2_RNA|COQ2_uc003hoh.1_Nonsense_Mutation_p.W217*	NM_015697	NP_056512	Q96H96	COQ2_HUMAN	para-hydroxybenzoate-polyprenyltransferase,	204	Helical; (Potential).				glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			ovary(1)|central_nervous_system(1)	2		Hepatocellular(203;0.114)				CTAGTTGAGGCCAGTATGAAA	0.358													0	0	0	0.00308	0	6	7										T	84193256	C	T	84193256	4	4	127	1	0	0	0	0	0	1	0	0	3745	740	26	2	519	2	COQ2	4	84193256	Nonsense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	2166180	84193256	106961020	43	37895										
SPARCL1	8404	broad.mit.edu	37	chr4	88414989	88414989	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccatcatcagtaggttccatGagcagagcctcagaaacagt	9	11	3	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr4:88414989G>A	uc010ikm.2	-	5	1535	c.963C>T	c.(961-963)CTC>CTT	p.L321L	SPARCL1_uc011cdc.1_Silent_p.L196L|SPARCL1_uc003hqs.3_Silent_p.L321L|SPARCL1_uc011cdd.1_Silent_p.L196L|SPARCL1_uc003hqt.2_Silent_p.L321L	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	321					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TAGGTTCCATGAGCAGAGCCT	0.408													0	0	0	0.00278	0	22	101										A	88414989	G	A	88414989	2	1	127	1	0	0	0	0	0	0	0	1	14995	1277	45	1		1	SPARCL1	4	88414989	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	4221733	88414989	102739287	44	37896										
CTSO	1519	broad.mit.edu	37	chr4	156850813	156850813	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	catctactatgactaccaaaGggccaaaggtaagaagtgct	9	9	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr4:156850813G>T	uc003ipg.2	-	6	768	c.719C>A	c.(718-720)CCT>CAT	p.P240H		NM_001334	NP_001325	P43234	CATO_HUMAN	cathepsin O preproprotein	240					proteolysis	lysosome	cysteine-type endopeptidase activity				0	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.05)|Kidney(143;0.0627)|COAD - Colon adenocarcinoma(41;0.148)		GACTACCAAAGGGCCAAAGGT	0.378													1	0	5.18039e-06	0.00308	5.41235e-06	8	16										T	156850813	G	T	156850813	3	4	127	1	0	0	0	0	1	0	0	0	4040	1000	35	4	258	4	CTSO	4	156850813	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	68435824	156850813	34303463	45	37897										
RXFP3	51289	broad.mit.edu	37	chr5	33937235	33937235	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctggcgctgacggactttcaGtttgtgctcaccctgccctt	10	14	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:33937235G>A	uc003jic.1	+	1	747	c.390G>A	c.(388-390)CAG>CAA	p.Q130Q		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	130	Helical; Name=2; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CGGACTTTCAGTTTGTGCTCA	0.567													0	0	0	0.000602	0	4	89										A	33937235	G	A	33937235	2	1	127	1	0	0	0	0	0	0	0	1	13761	1020	36	2		2	RXFP3	5	33937235	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		33937235	146978025	46	37898										
CWC27	10283	broad.mit.edu	37	chr5	64081347	64081347	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ataacatgttgcgactgtcaGaagtagacattgatgatgac	10	6	1	5			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:64081347G>C	uc003jtn.1	+	5	655	c.436G>C	c.(436-438)GAA>CAA	p.E146Q	CWC27_uc003jtl.2_Missense_Mutation_p.E146Q|CWC27_uc003jtm.2_Missense_Mutation_p.E146Q|CWC27_uc010iwt.1_Missense_Mutation_p.E146Q	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	146	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						GCGACTGTCAGAAGTAGACAT	0.333													0	0	0	0.003163	0	12	20										C	64081347	G	C	64081347	3	2	127	1	0	0	0	0	1	0	0	0	4070	943	33	1	454	1	CWC27	5	64081347	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	30144112	64081347	116833913	47	37899										
SLCO6A1	133482	broad.mit.edu	37	chr5	101735415	101735415	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctgcatctgcagttattaatCcttctttaatgcaagaacaa	5	9	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:101735415C>A	uc003knn.2	-	10	1830	c.1658G>T	c.(1657-1659)GGA>GTA	p.G553V	SLCO6A1_uc003kno.2_Missense_Mutation_p.G300V|SLCO6A1_uc003knp.2_Missense_Mutation_p.G553V|SLCO6A1_uc003knq.2_Missense_Mutation_p.G491V	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	553	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGTTATTAATCCTTCTTTAAT	0.323													1	0	0.00307968	0.00308	0.00313948	7	8										A	101735415	C	A	101735415	3	1	127	1	0	0	0	0	1	0	0	0	14732	855	30	3	517	3	SLCO6A1	5	101735415	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	37654068	101735415	79179845	48	37900										
MEGF10	84466	broad.mit.edu	37	chr5	126784798	126784799	+	Frame_Shift_Ins	INS	-	-	CAAT													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tatttttaacagtcaaaaaaINScaatcaactgtttgtgaatc							TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:126784798_126784799insCAAT	uc003kuh.3	+	23	3226_3227	c.2864_2865insCAAT	c.(2863-2865)AACfs	p.N955fs	MEGF10_uc003kui.3_Frame_Shift_Ins_p.N955fs	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	955	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CAGTCAAAAAACAATCAACTGT	0.446																		14	23	---	---								CAAT	126784799	-	CAAT	126784798	7	5	127	1	0	1	1	0	0	0	0	0	9460	43	2	0	2946	0	MEGF10	5	126784798	Frame_Shift_Ins	INS	-	TCGA-HQ-A2OE-01A-11D-A202-08	25049383	126784798	54130462	49	37901										
PRRC1	133619	broad.mit.edu	37	chr5	126860380	126860381	+	Frame_Shift_Ins	INS	-	-	A													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cttctgtcccaccacttgttINSacttctatgccacctcctgt							TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:126860380_126860381insA	uc003kuk.2	+	3	441_442	c.261_262insA	c.(259-264)GTTACTfs	p.V87fs	PRRC1_uc003kuj.3_Frame_Shift_Ins_p.V87fs	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	87_88	Pro-rich.					Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		CACCACTTGTTACTTCTATGCC	0.52																		63	98	---	---								A	126860381	-	A	126860380	7	5	127	1	0	1	1	0	0	0	0	0	12604	1741	61	0	267	0	PRRC1	5	126860380	Frame_Shift_Ins	INS	-	TCGA-HQ-A2OE-01A-11D-A202-08	75582	126860380	54054880	50	37902										
CAMLG	819	broad.mit.edu	37	chr5	134086448	134086448	+	Splice_Site	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttgagtctttctctacacaGagtgaaaagaagataaagac	8	6	2	6			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:134086448G>C	uc003kzt.2	+	4	805	c.700_splice	c.e4-1	p.S234_splice	CAMLG_uc003kzu.2_Splice_Site_p.E80_splice	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand						defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	TCTCTACACAGAGTGAAAAGA	0.358													0	0	0	0.004482	0	8	16										C	134086448	G	C	134086448	5	2	127	1	0	0	0	0	0	0	1	0	2609	956	33	1	713	1	CAMLG	5	134086448	Splice_Site	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	7226068	134086448	46828812	51	37903										
FGF18	8817	broad.mit.edu	37	chr5	170883752	170883752	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccggagcttcagaagcccttCaagtacacgacggtgaccaa	10	13	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr5:170883752C>T	uc003mbk.2	+	5	1104	c.567C>T	c.(565-567)TTC>TTT	p.F189F		NM_003862	NP_003853	O76093	FGF18_HUMAN	fibroblast growth factor 18 precursor	189					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGAAGCCCTTCAAGTACACGA	0.682													0	0	0	0.01441	0	53	9										T	170883752	C	T	170883752	2	4	127	1	0	0	0	0	0	0	0	1	5846	825	29	1		1	FGF18	5	170883752	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	36797304	170883752	10031508	52	37904										
HLA-B	3106	broad.mit.edu	37	chr6	31322894	31322894	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccttccctacctgaactcttCctcctacacatcacagcagc	3	19	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:31322894C>T	uc003nth.2	-	5	1056	c.1002G>A	c.(1000-1002)AGG>AGA	p.R334R	HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_5'Flank|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_RNA|HLA-B_uc003ntf.2_Intron|HLA-B_uc003ntg.1_Silent_p.R213R|HLA-B_uc003nti.1_Intron	NM_005514	NP_005505	P01889	1B07_HUMAN	major histocompatibility complex, class I, B	334	Cytoplasmic (Potential).				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity				0						CTGAACTCTTCCTCCTACACA	0.582									Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of				0	0	0	0.00245	0	14	102										T	31322894	C	T	31322894	2	4	127	1	0	0	0	0	0	0	0	1	7196	854	30	1		1	HLA-B	6	31322894	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		31322894	139792173	53	37905										
COL11A2	1302	broad.mit.edu	37	chr6	33136782	33136782	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtcaccaggaaaaccaacagGaccctgatccagatggagaa	10	11	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:33136782G>C	uc003ocx.1	-	52	4030	c.3802C>G	c.(3802-3804)CCT>GCT	p.P1268A	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.P1182A|COL11A2_uc003ocz.1_Missense_Mutation_p.P1161A	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1268	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						AAACCAACAGGACCCTGATCC	0.592													0	0	0	0.00278	0	23	41										C	33136782	G	C	33136782	3	2	127	1	0	0	0	0	1	0	0	0	3668	1174	41	1	1468	1	COL11A2	6	33136782	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1813888	33136782	137978285	54	37906										
PTCRA	171558	broad.mit.edu	37	chr6	42893345	42893345	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggtgctcaagatctgccctCagggctccttcctccagtct	9	15	4	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:42893345C>G	uc003osx.2	+	4	852	c.771C>G	c.(769-771)CTC>CTG	p.L257L	PTCRA_uc010jxy.2_Silent_p.L232L|PTCRA_uc010jxz.2_Silent_p.L150L	NM_138296	NP_612153	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha precursor	257	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(2)	2	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			GATCTGCCCTCAGGGCTCCTT	0.632													0	0	0	0.008291	0	11	12										G	42893345	C	G	42893345	2	3	127	1	0	0	0	0	0	0	0	1	12735	813	29	1		1	PTCRA	6	42893345	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	9756563	42893345	128221722	55	37907										
HSP90AB1	3326	broad.mit.edu	37	chr6	44221102	44221102	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaccgcatctatcgcatgatCaagctaggtctaggtaagta	9	9	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:44221102C>G	uc003oxa.1	+	11	2136	c.2052C>G	c.(2050-2052)ATC>ATG	p.I684M	HSP90AB1_uc011dvr.1_Missense_Mutation_p.I674M|HSP90AB1_uc003oxb.1_Missense_Mutation_p.I684M|HSP90AB1_uc011dvs.1_Missense_Mutation_p.I504M|HSP90AB1_uc003oxc.1_Missense_Mutation_p.I322M	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	684					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATCGCATGATCAAGCTAGGTC	0.483													0	0	0	0.01441	0	62	197										G	44221102	C	G	44221102	3	3	127	1	0	0	0	0	1	0	0	0	7402	816	29	1	2090	1	HSP90AB1	6	44221102	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	1327757	44221102	126893965	56	37908										
COL19A1	1310	broad.mit.edu	37	chr6	70639419	70639419	+	Frame_Shift_Del	DEL	C	C	-													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttagaaatcgagaactccgtCctttgtttgatcgtcagtgg					rs112596596	byFrequency	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:70639419delC	uc003pfc.1	+	6	610	c.493delC	c.(493-495)CCTfs	p.P165fs	COL19A1_uc010kam.1_Frame_Shift_Del_p.P61fs	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	165	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AGAACTCCGTCCTTTGTTTGA	0.393																		6	6	---	---								-	70639419	C	-	70639419	7	5	127	1	0	1	0	1	0	0	0	0	3676	855	30	0	511	0	COL19A1	6	70639419	Frame_Shift_Del	DEL	C	TCGA-HQ-A2OE-01A-11D-A202-08	26418317	70639419	100475648	57	37909										
LAMA2	3908	broad.mit.edu	37	chr6	129687390	129687390	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gagatgagtgcactggccttCttctcggtgacttggctcgc	13	11	2	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:129687390C>G	uc003qbn.2	+	33	4849	c.4744C>G	c.(4744-4746)CTT>GTT	p.L1582V	LAMA2_uc003qbo.2_Missense_Mutation_p.L1582V	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1582	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CACTGGCCTTCTTCTCGGTGA	0.463													0	0	0	0.012319	0	18	19										G	129687390	C	G	129687390	3	3	127	1	0	0	0	0	1	0	0	0	8606	913	32	1	4874	1	LAMA2	6	129687390	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	59047971	129687390	41427677	58	37910										
C6orf192	116843	broad.mit.edu	37	chr6	133105152	133105152	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	caataaaaggcacttcatagCcaaaggattgatacaaaaag	7	7	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:133105152C>A	uc003qdw.1	-	6	730	c.578G>T	c.(577-579)GGC>GTC	p.G193V	C6orf192_uc011eco.1_Missense_Mutation_p.G67V	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	hypothetical protein LOC116843	193	Extracellular (Potential).				transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)		CACTTCATAGCCAAAGGATTG	0.383													1	0	2.27111e-07	0.013537	2.38467e-07	12	23										A	133105152	C	A	133105152	3	1	127	1	0	0	0	0	1	0	0	0	2349	739	26	4	828	4	C6orf192	6	133105152	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	3417762	133105152	38009915	59	37911										
CCDC28A	25901	broad.mit.edu	37	chr6	139113917	139113917	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atttggcagatgcacaagatGttccaaatacttctgctagc	8	9	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr6:139113917G>A	uc003qie.2	+	6	957	c.802G>A	c.(802-804)GTT>ATT	p.V268I		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	268											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TGCACAAGATGTTCCAAATAC	0.338													0	0	0	0.00308	0	6	26										A	139113917	G	A	139113917	3	1	127	1	0	0	0	0	1	0	0	0	2802	1377	48	2	824	2	CCDC28A	6	139113917	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	6008765	139113917	32001150	60	37912										
CCDC126	90693	broad.mit.edu	37	chr7	23682709	23682709	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agtaaccacaaataaaagaaCgaatgtctcgggcagtatca	8	8	2	1	rs146283363	byFrequency	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:23682709C>T	uc003swl.2	+	4	855	c.398C>T	c.(397-399)ACG>ATG	p.T133M	CCDC126_uc003swm.2_Missense_Mutation_p.T133M|CCDC126_uc003swn.2_Missense_Mutation_p.T133M	NM_138771	NP_620126	Q96EE4	CC126_HUMAN	coiled-coil domain containing 126 precursor	133						extracellular region				ovary(1)|skin(1)	2						AATAAAAGAACGAATGTCTCG	0.428													0	0	0	0.00308	0	8	19										T	23682709	C	T	23682709	3	4	127	1	0	0	0	0	1	0	0	0	2762	536	19	2	404	2	CCDC126	7	23682709	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		23682709	135455954	61	37913										
TNS3	64759	broad.mit.edu	37	chr7	47408747	47408747	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gggccgactgaggcccttccGaggaggacagggtcccaagg	17	12	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:47408747G>A	uc003tnv.2	-	17	1863	c.1496C>T	c.(1495-1497)TCG>TTG	p.S499L	TNS3_uc003tnw.2_Missense_Mutation_p.S499L	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	499						focal adhesion	protein binding			ovary(4)	4						AGGCCCTTCCGAGGAGGACAG	0.592													0	0	0	0.004482	0	6	39										A	47408747	G	A	47408747	3	1	127	1	0	0	0	0	1	0	0	0	16341	1059	37	1	2901	1	TNS3	7	47408747	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	23726038	47408747	111729916	62	37914										
POM121L12	285877	broad.mit.edu	37	chr7	53104067	53104067	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccttcgtgcccaggccagggCctctgaagccgagcctcggc	13	17	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:53104067C>T	uc003tpz.2	+	1	719	c.703C>T	c.(703-705)CCT>TCT	p.P235S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	235											0						CAGGCCAGGGCCTCTGAAGCC	0.642													0	0	0	0.003163	0	14	56										T	53104067	C	T	53104067	3	4	127	1	0	0	0	0	1	0	0	0	12241	739	26	2	705	2	POM121L12	7	53104067	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	5695320	53104067	106034596	63	37915										
PSPH	5723	broad.mit.edu	37	chr7	56088853	56088853	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccgtgctgtcaacatcaaaaCacacagcatctgctgagtag	8	12	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:56088853C>A	uc003trg.2	-	3	416	c.53G>T	c.(52-54)TGT>TTT	p.C18F	PSPH_uc003trh.2_Missense_Mutation_p.C18F|PSPH_uc003tri.2_Missense_Mutation_p.C18F|PSPH_uc003trj.2_Missense_Mutation_p.C47F	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	18					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AACATCAAAACACACAGCATC	0.438													1	0	0.000219431	0.00245	0.000225885	15	76										A	56088853	C	A	56088853	3	1	127	1	0	0	0	0	1	0	0	0	12717	478	17	4	644	4	PSPH	7	56088853	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	2984786	56088853	103049810	64	37916										
MLXIPL	51085	broad.mit.edu	37	chr7	73011529	73011529	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cacctgctgtgagcagctgtGtgaggcaggggttgttgctc	16	9	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:73011529G>C	uc003tyn.1	-	9	1634	c.1586C>G	c.(1585-1587)ACA>AGA	p.T529R	MLXIPL_uc003tyj.1_5'UTR|MLXIPL_uc003tyk.1_Missense_Mutation_p.T529R|MLXIPL_uc003tyl.1_Missense_Mutation_p.T529R|MLXIPL_uc003tym.1_Missense_Mutation_p.T529R|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.T436R|MLXIPL_uc003tyq.1_Missense_Mutation_p.T271R	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	529					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GAGCAGCTGTGTGAGGCAGGG	0.672													0	0	0	0.009096	0	4	14										C	73011529	G	C	73011529	3	2	127	1	0	0	0	0	1	0	0	0	9637	1377	48	4	1008	4	MLXIPL	7	73011529	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	16922676	73011529	86127134	65	37917										
ZNF804B	219578	broad.mit.edu	37	chr7	88966018	88966018	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tctacatcctctttcacaggCacatttcagtcctatttcat	3	13	5	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:88966018C>T	uc011khi.1	+	4	4260	c.3722C>T	c.(3721-3723)GCA>GTA	p.A1241V		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1241						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTTTCACAGGCACATTTCAGT	0.468										HNSCC(36;0.09)			0	0	0	0.008871	0	21	63										T	88966018	C	T	88966018	3	4	127	1	0	0	0	0	1	0	0	0	18168	710	25	2	3736	2	ZNF804B	7	88966018	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	15954489	88966018	70172645	66	37918										
ANKIB1	54467	broad.mit.edu	37	chr7	91981821	91981821	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaataatcctgccattaaatGgtgtcctactccaggctgtg	8	10	0	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:91981821G>A	uc003ulw.2	+	9	1638	c.1262G>A	c.(1261-1263)TGG>TAG	p.W421*		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	421	IBR-type; degenerate.						protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GCCATTAAATGGTGTCCTACT	0.383													0	0	0	0.004482	0	7	40										A	91981821	G	A	91981821	4	1	127	1	0	0	0	0	0	1	0	0	630	1357	47	2	1292	2	ANKIB1	7	91981821	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	3015803	91981821	67156842	67	37919										
ANKIB1	54467	broad.mit.edu	37	chr7	91981845	91981845	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tcctactccaggctgtgacaGagcagtaagactaacgaaac	9	11	0	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:91981845G>C	uc003ulw.2	+	9	1662	c.1286G>C	c.(1285-1287)AGA>ACA	p.R429T		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	429	IBR-type; degenerate.						protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GGCTGTGACAGAGCAGTAAGA	0.398													0	0	0	0.00245	0	14	44										C	91981845	G	C	91981845	3	2	127	1	0	0	0	0	1	0	0	0	630	942	33	1	1316	1	ANKIB1	7	91981845	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	24	91981845	67156818	68	37920										
CTTNBP2	83992	broad.mit.edu	37	chr7	117375046	117375046	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cccaccgcagctgcacccagCggaaatgctgctgcaccagc	10	18	0	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:117375046C>T	uc003vjf.2	-	16	3889	c.3797G>A	c.(3796-3798)CGC>CAC	p.R1266H		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1266										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CTGCACCCAGCGGAAATGCTG	0.493													0	0	0	0.004482	0	9	30										T	117375046	C	T	117375046	3	4	127	1	0	0	0	0	1	0	0	0	4045	768	27	2	1226	2	CTTNBP2	7	117375046	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	25393201	117375046	41763617	69	37921										
XRCC2	7516	broad.mit.edu	37	chr7	152373252	152373252	+	Splice_Site	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gactctacggccagtcaaacCcgcccacccgcgcgcgtgcg	11	19	2	0	rs3218384	by1000genomes	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr7:152373252C>G	uc003wld.2	-	1	1	c.-85_splice	c.e1-1			NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2						meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		CCAGTCAAACCCGCCCACCCG	0.701								Homologous_recombination					0	0	0	0.004672	0	3	28										G	152373252	C	G	152373252	5	3	127	1	0	0	0	0	0	0	1	0	17450	638	22	4		4	XRCC2	7	152373252	Splice_Site	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	34998206	152373252	6765411	70	37922										
DEFA5	1670	broad.mit.edu	37	chr8	6912954	6912954	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggtttctatctaggaagctCagcgacagcagagtctgtag	12	8	4	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr8:6912954C>T	uc003wra.1	-	2	324	c.284G>A	c.(283-285)TGA>TAA	p.*95*		NM_021010	NP_066290	Q01523	DEF5_HUMAN	defensin, alpha 5 preproprotein	95					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CTAGGAAGCTCAGCGACAGCA	0.483													0	0	0	0.004482	0	9	9										T	6912954	C	T	6912954	2	4	127	1	0	0	0	0	0	0	0	1	4392	837	29	1		1	DEFA5	8	6912954	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		6912954	139451068	71	37923										
FGFR1	2260	broad.mit.edu	37	chr8	38275486	38275486	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cctgcccaaagcagccctctCccaggggtttgcctaagacc	9	17	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr8:38275486C>G	uc003xlp.2	-	12	2396	c.1454G>C	c.(1453-1455)GGA>GCA	p.G485A	FGFR1_uc010lwf.2_RNA|FGFR1_uc011lbo.1_Missense_Mutation_p.G483A|FGFR1_uc011lbp.1_Missense_Mutation_p.G396A|FGFR1_uc011lbq.1_Missense_Mutation_p.G394A|FGFR1_uc010lwk.2_Missense_Mutation_p.G475A	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	485	ATP.|Cytoplasmic (Potential).|Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	GCAGCCCTCTCCCAGGGGTTT	0.552		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						0	0	0	0.010771	0	46	25										G	38275486	C	G	38275486	3	3	127	1	0	0	0	0	1	0	0	0	5863	855	30	1	1046	1	FGFR1	8	38275486	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	31362532	38275486	108088536	72	37924										
MSC	9242	broad.mit.edu	37	chr8	72756080	72756080	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggcacgctcacgggcgttggCcgcgttccgctgcgactgct	15	15	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr8:72756080C>A	uc003xyx.1	-	1	652	c.334G>T	c.(334-336)GCC>TCC	p.A112S	uc011lff.1_Intron|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	112	Basic motif.				transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)			CGGGCGTTGGCCGCGTTCCGC	0.701											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	9.70103e-10	0.008291	1.0394e-09	11	25										A	72756080	C	A	72756080	3	1	127	1	0	0	0	0	1	0	0	0	9868	739	26	4	294	4	MSC	8	72756080	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	34480594	72756080	73607942	73	37925										
HNF4G	3174	broad.mit.edu	37	chr8	76468215	76468215	+	Splice_Site	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaactgagaatttttcattaAggtggcactgttgagagctc	10	6	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr8:76468215A>T	uc003yaq.2	+	7	775	c.505_splice	c.e7-2	p.V169_splice	HNF4G_uc003yar.2_Splice_Site_p.V206_splice	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma						endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TTTTTCATTAAGGTGGCACTG	0.333													0	0	0	0.000602	0	5	8										T	76468215	A	T	76468215	5	4	127	1	0	0	0	0	0	0	1	0	7254	86	3	5	636	5	HNF4G	8	76468215	Splice_Site	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08	3712135	76468215	69895807	74	37926										
IMPA1	3612	broad.mit.edu	37	chr8	82592977	82592977	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaatcaactggagaacttttCagcataacattcatttcatt	4	8	4	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr8:82592977C>A	uc003ych.2	-	3	232	c.105G>T	c.(103-105)CTG>CTT	p.L35L	IMPA1_uc011lfq.1_Silent_p.L94L|IMPA1_uc011lfr.1_Silent_p.L35L	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	35					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)	GAGAACTTTTCAGCATAACAT	0.299													1	0	5.16669e-11	0.010729	5.56412e-11	12	63										A	82592977	C	A	82592977	2	1	127	1	0	0	0	0	0	0	0	1	7722	813	29	3		3	IMPA1	8	82592977	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	6124762	82592977	63771045	75	37927										
DCAF10	79269	broad.mit.edu	37	chr9	37842171	37842171	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gaaaattgaacaccaaagtaTgcactttacatggtcacact	6	9	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr9:37842171T>C	uc004aao.2	+	3	813	c.739T>C	c.(739-741)TGC>CGC	p.C247R	DCAF10_uc010mlz.2_Missense_Mutation_p.C74R	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	247	WD 2.					CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						CACCAAAGTATGCACTTTACA	0.368													0	0	0	0.008871	0	19	26										C	37842171	T	C	37842171	3	2	127	1	0	0	0	0	1	0	0	0	4261	1464	51	5	749	5	DCAF10	9	37842171	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08		37842171	103371260	76	37928										
ANXA1	301	broad.mit.edu	37	chr9	75777739	75777739	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aagacataacctcagacacaTctggagattttcggaacgct	8	10	2	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr9:75777739T>C	uc004ajf.1	+	7	591	c.517T>C	c.(517-519)TCT>CCT	p.S173P	ANXA1_uc004aje.1_Missense_Mutation_p.S173P|ANXA1_uc004ajg.1_Missense_Mutation_p.S173P	NM_000700	NP_000691	P04083	ANXA1_HUMAN	annexin I	173	Annexin 2.				alpha-beta T cell differentiation|anti-apoptosis|cell surface receptor linked signaling pathway|cellular component movement|inflammatory response|keratinocyte differentiation|lipid metabolic process|peptide cross-linking|positive regulation of vesicle fusion	basolateral plasma membrane|cilium|cornified envelope|cytoplasm|extracellular region|nucleus	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity|protein binding, bridging|receptor binding|structural molecule activity			breast(1)|central_nervous_system(1)	2		all_epithelial(88;2.54e-11)		OV - Ovarian serous cystadenocarcinoma(323;2.82e-06)|GBM - Glioblastoma multiforme(74;0.0325)	Alclometasone(DB00240)|Amcinonide(DB00288)|Beclomethasone(DB00394)|Betamethasone(DB00443)|Clobetasol(DB01013)|Clocortolone(DB00838)|Desonide(DB01260)|Desoximetasone(DB00547)|Dexamethasone(DB01234)|Diflorasone(DB00223)|Flumethasone Pivalate(DB00663)|Halobetasol Propionate(DB00596)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mometasone(DB00764)|Prednicarbate(DB01130)|Prednisone(DB00635)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CTCAGACACATCTGGAGATTT	0.308													0	0	0	0.004672	0	3	1										C	75777739	T	C	75777739	3	2	127	1	0	0	0	0	1	0	0	0	714	1435	50	5	539	5	ANXA1	9	75777739	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	37935568	75777739	65435692	77	37929										
SCAI	286205	broad.mit.edu	37	chr9	127781102	127781102	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttattacaattaccaataatGagtgcgtcagccagagacaa	7	8	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr9:127781102G>A	uc004bpe.2	-	9	918	c.837C>T	c.(835-837)CTC>CTT	p.L279L	SCAI_uc004bpd.2_Silent_p.L302L|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	279					negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						TACCAATAATGAGTGCGTCAG	0.378													0	0	0	0.00278	0	22	31										A	127781102	G	A	127781102	2	1	127	1	0	0	0	0	0	0	0	1	13869	1277	45	1		1	SCAI	9	127781102	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	52003363	127781102	13432329	78	37930										
PRRX2	51450	broad.mit.edu	37	chr9	132481528	132481528	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aggtgagtgtcccagcccggGgcgcggtagcgccgccaagc	17	14	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr9:132481528G>A	uc004byh.2	+	2	505	c.278G>A	c.(277-279)GGG>GAG	p.G93E		NM_016307	NP_057391	Q99811	PRRX2_HUMAN	paired related homeobox 2	93						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		Ovarian(14;0.00556)				CCCAGCCCGGGGCGCGGTAGC	0.672													0	0	0	0.00308	0	8	4										A	132481528	G	A	132481528	3	1	127	1	0	0	0	0	1	0	0	0	12613	1232	43	2	284	2	PRRX2	9	132481528	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	4700426	132481528	8731903	79	37931										
PNPLA7	375775	broad.mit.edu	37	chr9	140379137	140379137	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccgtggacaggttgacagccGggttccccaagtcccacttg	12	14	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr9:140379137G>A	uc004cnf.2	-	20	2511	c.2174C>T	c.(2173-2175)CCG>CTG	p.P725L	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_5'UTR|PNPLA7_uc004cne.1_5'UTR|PNPLA7_uc011mfa.1_Missense_Mutation_p.P133L|PNPLA7_uc010ncj.1_Missense_Mutation_p.P750L	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	725					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GTTGACAGCCGGGTTCCCCAA	0.662													0	0	0	0.004672	0	3	11										A	140379137	G	A	140379137	3	1	127	1	0	0	0	0	1	0	0	0	12170	1116	39	2	1839	2	PNPLA7	9	140379137	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	7897609	140379137	834294	80	37932										
ZMYND19	116225	broad.mit.edu	37	chr9	140481554	140481554	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gggccacgcccccccggtgcCgctccctagaaacagacagc	11	19	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr9:140481554C>T	uc004cno.1	-	4	446	c.224G>A	c.(223-225)CGG>CAG	p.R75Q		NM_138462	NP_612471	Q96E35	ZMY19_HUMAN	zinc finger, MYND domain containing 19	75						Golgi apparatus|plasma membrane	zinc ion binding			skin(1)	1	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000275)|Epithelial(140;0.00047)		CCCCCGGTGCCGCTCCCTAGA	0.622													0	0	0	0.008291	0	10	55										T	140481554	C	T	140481554	3	4	127	1	0	0	0	0	1	0	0	0	17707	652	23	2	471	2	ZMYND19	9	140481554	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	102417	140481554	731877	81	37933										
KIN	22944	broad.mit.edu	37	chr10	7816818	7816818	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	acttggaagatgttgctccgGatgagctacatgctccttta	10	9	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:7816818G>A	uc001ijt.2	-	7	692	c.644C>T	c.(643-645)TCC>TTC	p.S215F	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.S215F|KIN_uc010qba.1_Missense_Mutation_p.S109F	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	215					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TGTTGCTCCGGATGAGCTACA	0.313													0	0	0	0.008871	0	18	87										A	7816818	G	A	7816818	3	1	127	1	0	0	0	0	1	0	0	0	8315	1174	41	1	565	1	KIN	10	7816818	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		7816818	127717929	82	37934										
DCLRE1C	64421	broad.mit.edu	37	chr10	14977537	14977537	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agtctcctgtgtacaggacaGttccattattgccctgaaat	8	10	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:14977537G>C	uc001inn.2	-	6	474	c.389C>G	c.(388-390)ACT>AGT	p.T130S	DCLRE1C_uc010qbx.1_Missense_Mutation_p.T130S|DCLRE1C_uc001inl.2_Missense_Mutation_p.T10S|DCLRE1C_uc009xji.2_Missense_Mutation_p.T15S|DCLRE1C_uc001inm.2_Missense_Mutation_p.T10S|DCLRE1C_uc001ino.2_Missense_Mutation_p.T15S|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Missense_Mutation_p.T10S|DCLRE1C_uc001inq.2_Missense_Mutation_p.T10S|DCLRE1C_uc001inr.2_Missense_Mutation_p.T15S|DCLRE1C_uc009xjj.1_5'Flank	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	130					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						GTACAGGACAGTTCCATTATT	0.443								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					0	0	0	0.007413	0	17	116										C	14977537	G	C	14977537	3	2	127	1	0	0	0	0	1	0	0	0	4296	1029	36	4	1725	4	DCLRE1C	10	14977537	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	7160719	14977537	120557210	83	37935										
ITGA8	8516	broad.mit.edu	37	chr10	15639284	15639301	+	Splice_Site	DEL	CAGTGGTCGAAATCCCTA	CAGTGGTCGAAATCCCTA	-													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tccatcttgtactcacagctCagtggtcgaaatccctacaa							TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:15639284_15639301delCAGTGGTCGAAATCCCTA	uc001ioc.1	-	21	2119	c.2119_splice	c.e21-1	p.G707_splice	ITGA8_uc010qcb.1_Splice_Site_p.G692_splice	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor						cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ACTCACAGCTCAGTGGTCGAAATCCCTACAATTGCAAA	0.491																		8	36	---	---								-	15639301	CAGTGGTCGAAATCCCTA	-	15639284	8	5	127	1	0	1	0	1	0	0	1	0	7882	813	29	0	1098	0	ITGA8	10	15639284	Splice_Site	DEL	CAGTGGTCGAAATCCCTA	TCGA-HQ-A2OE-01A-11D-A202-08	661747	15639284	119895463	84	37936										
CCNY	219771	broad.mit.edu	37	chr10	35819118	35819118	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agcagatttaccggttcgttCggacactgttcagtgctgct	11	10	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:35819118C>T	uc001iyw.3	+	7	706	c.526C>T	c.(526-528)CGG>TGG	p.R176W	CCNY_uc001iyu.3_Missense_Mutation_p.R122W|CCNY_uc001iyv.3_Missense_Mutation_p.R122W|CCNY_uc001iyx.3_Missense_Mutation_p.R122W|CCNY_uc009xmb.2_Missense_Mutation_p.R151W|CCNY_uc010qet.1_Missense_Mutation_p.R43W	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1	176	Cyclin N-terminal.				cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						CCGGTTCGTTCGGACACTGTT	0.532													0	0	0	0.004007	0	17	42										T	35819118	C	T	35819118	3	4	127	1	0	0	0	0	1	0	0	0	2936	875	31	1	552	1	CCNY	10	35819118	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	20179834	35819118	99715629	85	37937										
C10orf72	196740	broad.mit.edu	37	chr10	50227712	50227712	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtactacagcttgttctcctCgaagaggatctgggcgtaga	12	9	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:50227712C>T	uc001jhf.2	-	8	975	c.946G>A	c.(946-948)GAG>AAG	p.E316K		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						TTGTTCTCCTCGAAGAGGATC	0.522													0	0	0	0.008871	0	18	59										T	50227712	C	T	50227712	3	4	127	1	0	0	0	0	1	0	0	0	1615	893	31	1	20	1	C10orf72	10	50227712	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	14408594	50227712	85307035	86	37938										
CTNNA3	29119	broad.mit.edu	37	chr10	68979430	68979430	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggtggggttgtcatattctGgatcccttgtgaagcatttg	13	6	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:68979430G>A	uc009xpn.1	-	6	901	c.778C>T	c.(778-780)CAG>TAG	p.Q260*	CTNNA3_uc001jmw.2_Nonsense_Mutation_p.Q260*|CTNNA3_uc001jmx.3_Nonsense_Mutation_p.Q260*|CTNNA3_uc009xpo.1_Nonsense_Mutation_p.Q120*|CTNNA3_uc001jna.2_Nonsense_Mutation_p.Q272*	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	260					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						GTCATATTCTGGATCCCTTGT	0.458													0	0	0	0.000602	0	5	112										A	68979430	G	A	68979430	4	1	127	1	0	0	0	0	0	1	0	0	4014	1357	47	2	1961	2	CTNNA3	10	68979430	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	18751718	68979430	66555317	87	37939										
TTC18	118491	broad.mit.edu	37	chr10	75013740	75013740	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agctggaggggtatcagaaaGatggatttccaaagccaact	12	7	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:75013740G>C	uc009xrc.2	-	28	3480	c.3359C>G	c.(3358-3360)TCT>TGT	p.S1120C	TTC18_uc001jty.2_Missense_Mutation_p.S1120C|MRPS16_uc010qkh.1_5'Flank|MRPS16_uc001jts.1_5'Flank|MRPS16_uc001jtt.1_5'Flank|uc001jtu.1_RNA|TTC18_uc001jtv.3_Missense_Mutation_p.S224C|TTC18_uc001jtw.3_Missense_Mutation_p.S194C|TTC18_uc001jtx.2_Missense_Mutation_p.S471C	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	1120							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					GTATCAGAAAGATGGATTTCC	0.458													0	0	0	0.00278	0	21	83										C	75013740	G	C	75013740	3	2	127	1	0	0	0	0	1	0	0	0	16682	942	33	1	10	1	TTC18	10	75013740	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	6034310	75013740	60521007	88	37940										
GBF1	8729	broad.mit.edu	37	chr10	104123535	104123535	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cagatccacgggaactaattGaaattaaaaacaaaaagaag	7	6	0	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:104123535G>A	uc001kux.1	+	17	2323	c.2083G>A	c.(2083-2085)GAA>AAA	p.E695K	GBF1_uc001kuy.1_Missense_Mutation_p.E695K|GBF1_uc001kuz.1_Missense_Mutation_p.E696K	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	695	SEC7.				COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GGAACTAATTGAAATTAAAAA	0.463													0	0	0	0.00333	0	24	96										A	104123535	G	A	104123535	3	1	127	1	0	0	0	0	1	0	0	0	6271	1291	45	1	2145	1	GBF1	10	104123535	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	29109795	104123535	31411212	89	37941										
C10orf79	80217	broad.mit.edu	37	chr10	105912421	105912421	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaaaagtcttttcaaatgttCatcaaaggcctgtgtgcttt	7	7	4	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:105912421C>T	uc001kxw.2	-	28	3720	c.3604G>A	c.(3604-3606)GAA>AAA	p.E1202K	C10orf79_uc009xxq.2_Missense_Mutation_p.E510K	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1202	Potential.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		TTCAAATGTTCATCAAAGGCC	0.328													0	0	0	0.001168	0	5	40										T	105912421	C	T	105912421	3	4	127	1	0	0	0	0	1	0	0	0	1618	835	29	1	1437	1	C10orf79	10	105912421	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	1788886	105912421	29622326	90	37942										
TDRD1	56165	broad.mit.edu	37	chr10	115962010	115962010	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	attgcagtttccacaaacttGaaaataaatcatctattgaa	4	7	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:115962010G>A	uc001lbg.1	+	6	802	c.649G>A	c.(649-651)GAA>AAA	p.E217K	TDRD1_uc001lbf.2_Missense_Mutation_p.E208K|TDRD1_uc001lbh.1_Missense_Mutation_p.E208K|TDRD1_uc001lbi.1_Missense_Mutation_p.E208K|TDRD1_uc010qsc.1_5'Flank|TDRD1_uc001lbj.2_5'Flank	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	217					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		CCACAAACTTGAAAATAAATC	0.299													0	0	0	0.008291	0	11	23										A	115962010	G	A	115962010	3	1	127	1	0	0	0	0	1	0	0	0	15727	1291	45	1	667	1	TDRD1	10	115962010	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	10049589	115962010	19572737	91	37943										
FOXI2	399823	broad.mit.edu	37	chr10	129536033	129536033	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gcttcaagaaggtgccccgcGacgaggacgacccaggtaac	13	13	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:129536033G>A	uc009yas.2	+	1	496	c.496G>A	c.(496-498)GAC>AAC	p.D166N	uc009yar.1_5'Flank	NM_207426	NP_997309	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	166	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				GGTGCCCCGCGACGAGGACGA	0.667													0	0	0	0.009096	0	4	19										A	129536033	G	A	129536033	3	1	127	1	0	0	0	0	1	0	0	0	6010	1058	37	1	498	1	FOXI2	10	129536033	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	13574023	129536033	5998714	92	37944										
PPP2R2D	55844	broad.mit.edu	37	chr10	133769275	133769275	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	accctggaggcctcgagagaGagcagcaaaccgcgcgccag	14	14	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr10:133769275G>C	uc001lks.2	+	7	1314	c.1071G>C	c.(1069-1071)GAG>GAC	p.E357D	PPP2R2D_uc001lkr.2_Missense_Mutation_p.E163D|PPP2R2D_uc001lkt.2_Missense_Mutation_p.E163D|PPP2R2D_uc009yay.2_Missense_Mutation_p.E225D	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	390					cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		CCTCGAGAGAGAGCAGCAAAC	0.547													0	0	0	0.007413	0	19	46										C	133769275	G	C	133769275	3	2	127	1	0	0	0	0	1	0	0	0	12387	933	33	1	1098	1	PPP2R2D	10	133769275	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	4233242	133769275	1765472	93	37945										
OR51M1	390059	broad.mit.edu	37	chr11	5411026	5411026	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gctcctcatgatgtcctttgAccgccttgtggccatctgcc	9	15	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:5411026A>T	uc010qzc.1	+	1	398	c.398A>T	c.(397-399)GAC>GTC	p.D133V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	133						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGTCCTTTGACCGCCTTGTG	0.507													0	0	0	0.009096	0	4	69										T	5411026	A	T	5411026	3	4	127	1	0	0	0	0	1	0	0	0	11103	275	10	5	400	5	OR51M1	11	5411026	Missense_Mutation	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08		5411026	129595490	94	37946										
RAG2	5897	broad.mit.edu	37	chr11	36614207	36614207	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccagaaccttttttacggagGgatttcattggaggcttttt	10	7	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:36614207G>T	uc001mwv.3	-	2	1700	c.1512C>A	c.(1510-1512)TCC>TCA	p.S504S	RAG1_uc001mwt.2_Intron|C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	504					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TTTTACGGAGGGATTTCATTG	0.413									Familial_Hemophagocytic_Lymphohistiocytosis				1	0	8.28177e-16	0.007413	9.10561e-16	18	44										T	36614207	G	T	36614207	2	4	127	1	0	0	0	0	0	0	0	1	13005	1219	43	4		4	RAG2	11	36614207	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	31203181	36614207	98392309	95	37947										
FNBP4	23360	broad.mit.edu	37	chr11	47741610	47741610	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tctgccacttttttaccaaaGatggcattttggtcttactc	6	10	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:47741610G>C	uc009ylv.2	-	16	2987	c.2834C>G	c.(2833-2835)TCT>TGT	p.S945C	FNBP4_uc001ngi.2_Missense_Mutation_p.S259C|FNBP4_uc001ngj.2_Missense_Mutation_p.S852C	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	945										ovary(1)	1						TTTTACCAAAGATGGCATTTT	0.398													0	0	0	0.013537	0	11	24										C	47741610	G	C	47741610	3	2	127	1	0	0	0	0	1	0	0	0	5967	942	33	1	227	1	FNBP4	11	47741610	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	11127403	47741610	87264906	96	37948										
OR5D18	219438	broad.mit.edu	37	chr11	55587183	55587183	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gattacccagaactgcaagtCccactcttcctggtttttct	6	13	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:55587183C>G	uc010rin.1	+	1	78	c.78C>G	c.(76-78)GTC>GTG	p.V26V		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	26	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				AACTGCAAGTCCCACTCTTCC	0.463													0	0	0	0.004482	0	8	30										G	55587183	C	G	55587183	2	3	127	1	0	0	0	0	0	0	0	1	11157	842	30	1		1	OR5D18	11	55587183	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	7845573	55587183	79419333	97	37949										
OR8K3	219473	broad.mit.edu	37	chr11	56085825	56085825	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cggtgaatgaattcattcttAcgggaatcacagatatcgct	9	8	3	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:56085825A>T	uc010rjf.1	+	1	43	c.43A>T	c.(43-45)ACG>TCG	p.T15S		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ATTCATTCTTACGGGAATCAC	0.418													0	0	0	0.004672	0	3	40										T	56085825	A	T	56085825	3	4	127	1	0	0	0	0	1	0	0	0	11244	391	14	5	45	5	OR8K3	11	56085825	Missense_Mutation	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08	498642	56085825	78920691	98	37950										
C11orf84	144097	broad.mit.edu	37	chr11	63585488	63585488	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cgctcgcacatcttggagcaGcaccctcacaccttggacct	8	17	2	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:63585488G>C	uc001nxt.2	+	2	575	c.339G>C	c.(337-339)CAG>CAC	p.Q113H		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	113											0						TCTTGGAGCAGCACCCTCACA	0.642													0	0	0	0.008291	0	10	51										C	63585488	G	C	63585488	3	2	127	1	0	0	0	0	1	0	0	0	1667	962	34	4	345	4	C11orf84	11	63585488	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	7499663	63585488	71421028	99	37951										
PPP1CA	5499	broad.mit.edu	37	chr11	67168200	67168200	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atgcggttgatgctggcacaCtcgtggttcccacggagcag	14	11	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:67168200C>G	uc001okw.1	-	3	501	c.378G>C	c.(376-378)GAG>GAC	p.E126D	PPP1CA_uc009yro.1_5'UTR|PPP1CA_uc001okt.1_Missense_Mutation_p.E131D|PPP1CA_uc001oku.1_Missense_Mutation_p.E137D|PPP1CA_uc001okv.1_Missense_Mutation_p.E82D|PPP1CA_uc001okx.1_Missense_Mutation_p.E214D|PPP1CA_uc001oky.2_Missense_Mutation_p.E126D	NM_002708	NP_002699	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha	126					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			TGCTGGCACACTCGTGGTTCC	0.562													0	0	0	0.00499	0	17	81										G	67168200	C	G	67168200	3	3	127	1	0	0	0	0	1	0	0	0	12349	564	20	4	634	4	PPP1CA	11	67168200	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	3582712	67168200	67838316	100	37952										
XRRA1	143570	broad.mit.edu	37	chr11	74556166	74556166	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cttggctgtcagcagttcttCatagccgtggtacttgctgg	12	10	3	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:74556166C>A	uc009yub.2	-	16	2187	c.1855G>T	c.(1855-1857)GAA>TAA	p.E619*	XRRA1_uc001ovm.2_RNA|XRRA1_uc001ovn.2_Nonsense_Mutation_p.E242*|XRRA1_uc001ovo.2_Nonsense_Mutation_p.E227*|XRRA1_uc001ovq.3_Nonsense_Mutation_p.E532*|XRRA1_uc001ovp.3_Nonsense_Mutation_p.E344*|XRRA1_uc001ovr.2_Nonsense_Mutation_p.E242*|XRRA1_uc001ovs.1_Nonsense_Mutation_p.E221*	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	619					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						AGCAGTTCTTCATAGCCGTGG	0.537													1	0	2.01872e-29	0.01441	2.25495e-29	41	105										A	74556166	C	A	74556166	4	1	127	1	0	0	0	0	0	1	0	0	17458	835	29	3	539	3	XRRA1	11	74556166	Nonsense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	7387966	74556166	60450350	101	37953										
C11orf82	220042	broad.mit.edu	37	chr11	82642952	82642952	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttgcagacttttaatttcaGgaaacttcagtgtgactctc	7	8	3	2	rs143776868	byFrequency	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:82642952G>A	uc001ozt.2	+	6	816	c.572G>A	c.(571-573)AGG>AAG	p.R191K	C11orf82_uc010rsr.1_5'UTR|C11orf82_uc010rss.1_5'UTR|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	191					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TTTAATTTCAGGAAACTTCAG	0.408													0	0	0	0.000602	0	4	87										A	82642952	G	A	82642952	3	1	127	1	0	0	0	0	1	0	0	0	1665	1000	35	2	586	2	C11orf82	11	82642952	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	8086786	82642952	52363564	102	37954										
C11orf63	79864	broad.mit.edu	37	chr11	122795698	122795698	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atcctgaagataaatggcatCaaagagcacaacagctaaag	8	8	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr11:122795698C>T	uc001pym.2	+	4	1255	c.958C>T	c.(958-960)CAA>TAA	p.Q320*		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	320										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TAAATGGCATCAAAGAGCACA	0.408													0	0	0	0.004656	0	26	8										T	122795698	C	T	122795698	4	4	127	1	0	0	0	0	0	1	0	0	1654	827	29	1	1032	1	C11orf63	11	122795698	Nonsense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	40152746	122795698	12210818	103	37955										
VWF	7450	broad.mit.edu	37	chr12	6161750	6161750	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aagatgtcttctggctggaaGatctcaccgtcatagtaaca	9	9	4	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:6161750G>C	uc001qnn.1	-	16	2395	c.2145C>G	c.(2143-2145)ATC>ATG	p.I715M	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	715					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CTGGCTGGAAGATCTCACCGT	0.512													0	0	0	0.01441	0	109	133										C	6161750	G	C	6161750	3	2	127	1	0	0	0	0	1	0	0	0	17243	932	33	1	6444	1	VWF	12	6161750	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		6161750	127690145	104	37956										
CDCA3	83461	broad.mit.edu	37	chr12	6958994	6958994	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tcagtttcaaatacttcactCagctgtttcaccagtgggct	7	11	5	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:6958994C>T	uc001qrg.2	-	4	407	c.279G>A	c.(277-279)CTG>CTA	p.L93L	CDCA3_uc001qre.2_Silent_p.L93L|uc001qrf.1_5'Flank|USP5_uc001qri.3_5'Flank|USP5_uc001qrh.3_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	93	F-box-like.				cell division|mitosis	cytosol					0						ATACTTCACTCAGCTGTTTCA	0.463													0	0	0	0.014323	0	23	119										T	6958994	C	T	6958994	2	4	127	1	0	0	0	0	0	0	0	1	3087	813	29	1		1	CDCA3	12	6958994	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	797244	6958994	126892901	105	37957										
C1S	716	broad.mit.edu	37	chr12	7177163	7177163	+	Nonsense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttttattccttcctagtctgTggagtccccagagaaccctt	7	12	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:7177163T>A	uc001qsj.2	+	15	1994	c.1275T>A	c.(1273-1275)TGT>TGA	p.C425*	C1S_uc001qsk.2_Nonsense_Mutation_p.C425*|C1S_uc001qsl.2_Nonsense_Mutation_p.C425*|C1S_uc009zfr.2_Nonsense_Mutation_p.C258*|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	425					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TCCTAGTCTGTGGAGTCCCCA	0.443													0	0	0	0.00278	0	22	128										A	7177163	T	A	7177163	4	1	127	1	0	0	0	0	0	1	0	0	1974	1702	59	5	1317	5	C1S	12	7177163	Nonsense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	218169	7177163	126674732	106	37958										
CSDA	8531	broad.mit.edu	37	chr12	10854593	10854593	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtgaaggagcgttaggaggaCgcgggcgacgccggtaattg	19	7	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:10854593C>T	uc001qyt.2	-	8	1262	c.1019G>A	c.(1018-1020)CGT>CAT	p.R340H	CSDA_uc001qyu.2_Missense_Mutation_p.R271H	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	340					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					GTTAGGAGGACGCGGGCGACG	0.517													0	0	0	0.01441	0	111	194										T	10854593	C	T	10854593	3	4	127	1	0	0	0	0	1	0	0	0	3927	536	19	2	107	2	CSDA	12	10854593	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	3677430	10854593	122997302	107	37959										
C12orf35	55196	broad.mit.edu	37	chr12	32136551	32136551	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atagtactgttgtgagtagtGatacattacagattgacaat	9	4	0	4			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:32136551G>C	uc001rks.2	+	4	3076	c.2662G>C	c.(2662-2664)GAT>CAT	p.D888H		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	888										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			TGTGAGTAGTGATACATTACA	0.373													0	0	0	0.00623	0	40	56										C	32136551	G	C	32136551	3	2	127	1	0	0	0	0	1	0	0	0	1682	1290	45	1	2664	1	C12orf35	12	32136551	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	21281958	32136551	101715344	108	37960										
PKP2	5318	broad.mit.edu	37	chr12	32955491	32955491	+	Splice_Site	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgagccactgatgtcggcatCtgttttgtgagacatatcct	10	9	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:32955491C>A	uc001rlj.3	-	11	2261	c.2146_splice	c.e11-1	p.M716_splice	PKP2_uc001rlk.3_Splice_Site_p.M672_splice|PKP2_uc010skj.1_Splice_Site_p.M669_splice	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b						cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ATGTCGGCATCTGTTTTGTGA	0.408													1	0	8.60227e-14	0.004007	9.40874e-14	12	89										A	32955491	C	A	32955491	5	1	127	1	0	0	0	0	0	0	1	0	11985	927	32	3	516	3	PKP2	12	32955491	Splice_Site	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	818940	32955491	100896404	109	37961										
TMBIM6	7009	broad.mit.edu	37	chr12	50149478	50149478	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttggctgatggcaacacctCatagccatgaaactgaacag	9	10	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:50149478C>T	uc001rux.2	+	4	358	c.226C>T	c.(226-228)CAT>TAT	p.H76Y	TMBIM6_uc010sml.1_Missense_Mutation_p.H76Y|TMBIM6_uc001ruy.2_Missense_Mutation_p.H134Y|TMBIM6_uc001ruz.2_Missense_Mutation_p.H76Y	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	76					apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						GGCAACACCTCATAGCCATGA	0.433													0	0	0	0.003954	0	26	182										T	50149478	C	T	50149478	3	4	127	1	0	0	0	0	1	0	0	0	15980	826	29	1	414	1	TMBIM6	12	50149478	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	17193987	50149478	83702417	110	37962										
LIMA1	51474	broad.mit.edu	37	chr12	50571472	50571472	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	caggaggccatttgggctttGacattttgatcccttcctcc	9	12	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:50571472G>C	uc001rwj.3	-	11	1829	c.1655C>G	c.(1654-1656)TCA>TGA	p.S552*	LIMA1_uc001rwg.3_Nonsense_Mutation_p.S250*|LIMA1_uc001rwh.3_Nonsense_Mutation_p.S391*|LIMA1_uc001rwi.3_Nonsense_Mutation_p.S393*|LIMA1_uc001rwk.3_Nonsense_Mutation_p.S553*|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	552					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TTTGGGCTTTGACATTTTGAT	0.502													0	0	0	0.009535	0	31	183										C	50571472	G	C	50571472	4	2	127	1	0	0	0	0	0	1	0	0	8796	1294	45	1	628	1	LIMA1	12	50571472	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	421994	50571472	83280423	111	37963										
ERBB3	2065	broad.mit.edu	37	chr12	56482341	56482341	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccctagataactttgtggtgGatcaaacatcctgtgtcagg	10	9	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:56482341G>T	uc001sjh.2	+	8	1082	c.889G>T	c.(889-891)GAT>TAT	p.D297Y	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.D238Y|ERBB3_uc001sji.2_5'UTR	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	297	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTTTGTGGTGGATCAAACATC	0.512													1	0	8.8899e-71	0.01441	9.98331e-71	132	196										T	56482341	G	T	56482341	3	4	127	1	0	0	0	0	1	0	0	0	5208	1174	41	3	1050	3	ERBB3	12	56482341	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	5910869	56482341	77369554	112	37964										
GLS2	27165	broad.mit.edu	37	chr12	56865968	56865968	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tctgttccatatccatggctGacaaggcaaacctgagggta	10	10	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:56865968G>C	uc001slj.2	-	16	1802	c.1523C>G	c.(1522-1524)TCA>TGA	p.S508*	GLS2_uc009zos.2_RNA|GLS2_uc001slk.2_Nonsense_Mutation_p.S243*|GLS2_uc009zot.2_Nonsense_Mutation_p.S169*	NM_013267	NP_037399	Q9UI32	GLSL_HUMAN	glutaminase 2 precursor	508					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			ovary(1)|central_nervous_system(1)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ATCCATGGCTGACAAGGCAAA	0.502													0	0	0	0.01441	0	74	111										C	56865968	G	C	56865968	4	2	127	1	0	0	0	0	0	1	0	0	6464	1294	45	1	297	1	GLS2	12	56865968	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	383627	56865968	76985927	113	37965										
NUP107	57122	broad.mit.edu	37	chr12	69127366	69127366	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aagatgataatgctatccgaGaacatttgtgcatcagagct	9	7	1	4			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:69127366G>T	uc001suf.2	+	24	2351	c.2236G>T	c.(2236-2238)GAA>TAA	p.E746*	NUP107_uc001sug.2_Nonsense_Mutation_p.E505*|NUP107_uc010stj.1_Nonsense_Mutation_p.E717*	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	746					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TGCTATCCGAGAACATTTGTG	0.398													1	0	0.00198382	0.001984	0.0020322	7	121										T	69127366	G	T	69127366	4	4	127	1	0	0	0	0	0	1	0	0	10753	943	33	3	2330	3	NUP107	12	69127366	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	12261398	69127366	64724529	114	37966										
PPFIA2	8499	broad.mit.edu	37	chr12	81675058	81675058	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atggaaactatccaccatttTtaaatggacacggagatctt	7	8	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:81675058T>C	uc001szo.1	-	27	3351	c.3190A>G	c.(3190-3192)AAA>GAA	p.K1064E	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	963										ovary(3)|lung(2)|pancreas(1)	6						TCCACCATTTTTAAATGGACA	0.323													0	0	0	0.001168	0	6	16										C	81675058	T	C	81675058	3	2	127	1	0	0	0	0	1	0	0	0	12310	1850	64	5	607	5	PPFIA2	12	81675058	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	12547692	81675058	52176837	115	37967										
ACACB	32	broad.mit.edu	37	chr12	109625935	109625935	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tcccaatttgggcactgcttCtcctggggagagaaccggga	13	11	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:109625935C>G	uc001tob.2	+	13	2231	c.2112C>G	c.(2110-2112)TTC>TTG	p.F704L	ACACB_uc001toc.2_Missense_Mutation_p.F704L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	704	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GGCACTGCTTCTCCTGGGGAG	0.393													0	0	0	0.012319	0	20	110										G	109625935	C	G	109625935	3	3	127	1	0	0	0	0	1	0	0	0	107	912	32	1	2158	1	ACACB	12	109625935	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	27950877	109625935	24225960	116	37968										
GCN1L1	10985	broad.mit.edu	37	chr12	120565654	120565654	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgctgctggcccaggcctctCatgtcaggatggtgtcgtcc	13	13	2	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:120565654C>T	uc001txo.2	-	58	8028	c.8015G>A	c.(8014-8016)TGA>TAA	p.*2672*		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2672					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAGGCCTCTCATGTCAGGAT	0.542													0	0	0	0.008361	0	30	232										T	120565654	C	T	120565654	2	4	127	1	0	0	0	0	0	0	0	1	6299	837	29	1		1	GCN1L1	12	120565654	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	10939719	120565654	13286241	117	37969										
RSRC2	65117	broad.mit.edu	37	chr12	123001882	123001882	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttccctgcttctggatctcGatttcttcctctctctgctt	5	14	5	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:123001882G>A	uc001ucr.2	-	5	640	c.494C>T	c.(493-495)TCG>TTG	p.S165L	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_Missense_Mutation_p.S106L|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.S117L|RSRC2_uc001ucu.2_Missense_Mutation_p.S165L	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	165	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TCTGGATCTCGATTTCTTCCT	0.517													0	0	0	0.001855	0	13	115										A	123001882	G	A	123001882	3	1	127	1	0	0	0	0	1	0	0	0	13715	1059	37	1	834	1	RSRC2	12	123001882	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	2436228	123001882	10850013	118	37970										
SNRNP35	11066	broad.mit.edu	37	chr12	123950235	123950235	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaggtgtcataggagatcccCtcctcaccctgtttgtggcc	10	13	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:123950235C>T	uc001ufb.1	+	2	264	c.148C>T	c.(148-150)CTC>TTC	p.L50F	SNRNP35_uc010tar.1_Missense_Mutation_p.L55F|SNRNP35_uc009zxz.2_Missense_Mutation_p.L55F|SNRNP35_uc001ufc.1_Intron	NM_022717	NP_073208	Q16560	U1SBP_HUMAN	small nuclear ribonucleoprotein 35kDa (U11/U12)	50					mRNA processing	U12-type spliceosomal complex	nucleotide binding|RNA binding				0						AGGAGATCCCCTCCTCACCCT	0.557													0	0	0	0.006122	0	17	89										T	123950235	C	T	123950235	3	4	127	1	0	0	0	0	1	0	0	0	14855	681	24	2	169	2	SNRNP35	12	123950235	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	948353	123950235	9901660	119	37971										
DHX37	57647	broad.mit.edu	37	chr12	125473494	125473494	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agctgcacggggggcggctcGggggggcccttcgagggtcc	21	12	0	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr12:125473494G>A	uc001ugy.2	-	1	174	c.75C>T	c.(73-75)CCC>CCT	p.P25P		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	25							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GGGGCGGCTCGGGGGGGCCCT	0.711													0	0	0	0.003755	0	29	34										A	125473494	G	A	125473494	2	1	127	1	0	0	0	0	0	0	0	1	4510	1103	39	2		2	DHX37	12	125473494	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1523259	125473494	8378401	120	37972										
CCNA1	8900	broad.mit.edu	37	chr13	37012218	37012218	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttgcagtttcccctatgctgGtagattcatctctcctctcc	6	14	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr13:37012218G>A	uc001uvr.3	+	4	909	c.559G>A	c.(559-561)GTA>ATA	p.V187I	CCNA1_uc010teo.1_Missense_Mutation_p.V143I|CCNA1_uc010abq.2_Missense_Mutation_p.V143I|CCNA1_uc010abp.2_Missense_Mutation_p.V143I|CCNA1_uc001uvs.3_Missense_Mutation_p.V186I|CCNA1_uc010abr.2_Intron	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	187					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		CCCTATGCTGGTAGATTCATC	0.383													0	0	0	0.003755	0	36	53										A	37012218	G	A	37012218	3	1	127	1	0	0	0	0	1	0	0	0	2909	1261	44	2	573	2	CCNA1	13	37012218	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		37012218	78157660	121	37973										
OR4K5	79317	broad.mit.edu	37	chr14	20389081	20389081	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cccaaattttctttattcacCtttttactggaggggagatg	8	8	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr14:20389081C>A	uc010tkw.1	+	1	316	c.316C>A	c.(316-318)CTT>ATT	p.L106I		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTTATTCACCTTTTTACTGG	0.433													1	0	1.99824e-07	0.00499	2.10869e-07	18	44										A	20389081	C	A	20389081	3	1	127	1	0	0	0	0	1	0	0	0	11073	681	24	4	318	4	OR4K5	14	20389081	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		20389081	86960459	122	37974										
DHRS4L1	728635	broad.mit.edu	37	chr14	24520155	24520155	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggaaacagtgatggtgggtgGaggaaccccgtcccgcctct	15	11	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr14:24520155G>C	uc010alc.2	+	10	824	c.824G>C	c.(823-825)GGA>GCA	p.G275A	DHRS4L1_uc010tnu.1_RNA|LRRC16B_uc001wlj.2_5'Flank	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4	275							binding|oxidoreductase activity				0						ATGGTGGGTGGAGGAACCCCG	0.597													0	0	0	0.006214	0	8	22										C	24520155	G	C	24520155	3	2	127	1	0	0	0	0	1	0	0	0	4493	1174	41	1	862	1	DHRS4L1	14	24520155	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	4131074	24520155	82829385	123	37975										
FOXA1	3169	broad.mit.edu	37	chr14	38061168	38061169	+	Frame_Shift_Ins	INS	-	-	C													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gctcccgcccccgccgccggINScccccggctgcttctcgcac							TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr14:38061168_38061169insC	uc001wuf.2	-	2	1132_1133	c.820_821insG	c.(820-822)GCCfs	p.A274fs	FOXA1_uc010tpz.1_Frame_Shift_Ins_p.A241fs	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	274					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		cccgccgccggcccccgGCTGC	0.52																		13	3	---	---								C	38061169	-	C	38061168	7	5	127	1	0	1	1	0	0	0	0	0	5989	1203	42	0	601	0	FOXA1	14	38061168	Frame_Shift_Ins	INS	-	TCGA-HQ-A2OE-01A-11D-A202-08	13541013	38061168	69288372	124	37976										
SEC23A	10484	broad.mit.edu	37	chr14	39545169	39545169	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttttaacatatttggcattGtctttgtcaatgtcatgcca	6	7	3	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr14:39545169G>C	uc001wup.1	-	8	1180	c.957C>G	c.(955-957)GAC>GAG	p.D319E	SEC23A_uc010tqa.1_Missense_Mutation_p.D181E|SEC23A_uc010tqb.1_Missense_Mutation_p.D290E|SEC23A_uc010tqc.1_Missense_Mutation_p.D181E	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	319					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		ATTTGGCATTGTCTTTGTCAA	0.383													0	0	0	0.000602	0	5	18										C	39545169	G	C	39545169	3	2	127	1	0	0	0	0	1	0	0	0	13991	1368	48	4	1392	4	SEC23A	14	39545169	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1484001	39545169	67804371	125	37977										
AHNAK2	113146	broad.mit.edu	37	chr14	105409421	105409421	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttggcagtcacatccttgtCggccagggacaggtccccct	11	14	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr14:105409421C>T	uc010axc.1	-	7	12487	c.12367G>A	c.(12367-12369)GAC>AAC	p.D4123N	AHNAK2_uc001ypx.2_Missense_Mutation_p.D4023N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4123						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACATCCTTGTCGGCCAGGGAC	0.587													0	0	0	0.01441	0	96	250										T	105409421	C	T	105409421	3	4	127	1	0	0	0	0	1	0	0	0	415	884	31	1	5024	1	AHNAK2	14	105409421	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	65864252	105409421	1940119	126	37978										
MAGEL2	54551	broad.mit.edu	37	chr15	23889145	23889145	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tctctgctacacctattagcGgggagggggcctgctggtgg	16	10	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:23889145G>C	uc001ywj.3	-	1	2031	c.1936C>G	c.(1936-1938)CGC>GGC	p.R646G		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		ACCTATTAGCGGGGAGGGGGC	0.577													0	0	0	0.00308	0	8	16										C	23889145	G	C	23889145	3	2	127	1	0	0	0	0	1	0	0	0	9189	1116	39	4	8	4	MAGEL2	15	23889145	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		23889145	78642247	127	37979										
MAGEL2	54551	broad.mit.edu	37	chr15	23890799	23890799	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gccgctgctaccgggggtccGggctgggcctgcaagactgc	17	14	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:23890799G>C	uc001ywj.3	-	1	377	c.282C>G	c.(280-282)CCC>CCG	p.P94P		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CCGGGGGTCCGGGCTGGGCCT	0.652													0	0	0	0.000602	0	5	16										C	23890799	G	C	23890799	2	2	127	1	0	0	0	0	0	0	0	1	9189	1103	39	4		4	MAGEL2	15	23890799	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1654	23890799	78640593	128	37980										
PLA2G4F	255189	broad.mit.edu	37	chr15	42439886	42439886	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agaaggccgagctcctgcaaCcctgccaggctgccgtacag	12	15	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:42439886C>A	uc001zoz.2	-	12	1197	c.1134G>T	c.(1132-1134)GGG>GGT	p.G378G	PLA2G4F_uc010bcq.2_5'Flank|PLA2G4F_uc001zoy.2_Silent_p.G10G|PLA2G4F_uc010bcr.2_Silent_p.G129G|PLA2G4F_uc001zpa.2_Silent_p.G129G|PLA2G4F_uc010bcs.2_Silent_p.G165G	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	378	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GCTCCTGCAACCCTGCCAGGC	0.577													1	0	1.88708e-17	0.008361	2.08572e-17	30	83										A	42439886	C	A	42439886	2	1	127	1	0	0	0	0	0	0	0	1	12006	494	18	4		4	PLA2G4F	15	42439886	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	18549087	42439886	60091506	129	37981										
C15orf43	145645	broad.mit.edu	37	chr15	45270712	45270712	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atatcaattgatgccatgaaGaaattccttggggagctaca	9	7	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:45270712G>C	uc001zuk.2	+	7	566	c.549G>C	c.(547-549)AAG>AAC	p.K183N		NM_152448	NP_689661	Q8NHR7	CO043_HUMAN	hypothetical protein LOC145645	183											0		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		ATGCCATGAAGAAATTCCTTG	0.294													0	0	0	0.001984	0	7	20										C	45270712	G	C	45270712	3	2	127	1	0	0	0	0	1	0	0	0	1797	933	33	1	575	1	C15orf43	15	45270712	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	2830826	45270712	57260680	130	37982										
DUOX1	53905	broad.mit.edu	37	chr15	45454121	45454121	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cctggaccactcgcctcaggGagatctactcagccccgacg	10	17	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:45454121G>C	uc001zus.1	+	31	4388	c.4042G>C	c.(4042-4044)GAG>CAG	p.E1348Q	DUOX1_uc001zut.1_Missense_Mutation_p.E1348Q|DUOX1_uc010bee.1_Missense_Mutation_p.E728Q	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1348	Cytoplasmic (Potential).|FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TCGCCTCAGGGAGATCTACTC	0.617													0	0	0	0.00308	0	8	22										C	45454121	G	C	45454121	3	2	127	1	0	0	0	0	1	0	0	0	4800	1175	41	1	4156	1	DUOX1	15	45454121	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	183409	45454121	57077271	131	37983										
PRTG	283659	broad.mit.edu	37	chr15	55919293	55919293	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctacagcaatgccagtcattGatttttggtccagatggtaa	9	8	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:55919293G>C	uc002adg.2	-	17	2888	c.2840C>G	c.(2839-2841)TCA>TGA	p.S947*		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	947					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GCCAGTCATTGATTTTTGGTC	0.358													0	0	0	0.000602	0	5	31										C	55919293	G	C	55919293	4	2	127	1	0	0	0	0	0	1	0	0	12638	1294	45	1	628	1	PRTG	15	55919293	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	10465172	55919293	46612099	132	37984										
CLPX	10845	broad.mit.edu	37	chr15	65447318	65447318	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaccgatctttttcttcaatGtcttggtgagtattcgattc	7	8	4	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:65447318G>A	uc002aom.2	-	11	1485	c.1413C>T	c.(1411-1413)GAC>GAT	p.D471D	CLPX_uc010uiu.1_RNA	NM_006660	NP_006651	O76031	CLPX_HUMAN	ClpX caseinolytic protease X homolog precursor	471					protein folding|proteolysis involved in cellular protein catabolic process	mitochondrial endopeptidase Clp complex|mitochondrial inner membrane|mitochondrial nucleoid	ATP binding|ATPase activity|metal ion binding|peptidase activator activity|unfolded protein binding				0						TTTCTTCAATGTCTTGGTGAG	0.473													0	0	0	0.00245	0	15	24										A	65447318	G	A	65447318	2	1	127	1	0	0	0	0	0	0	0	1	3556	1368	48	2		2	CLPX	15	65447318	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	9528025	65447318	37084074	133	37985										
KIAA1024	23251	broad.mit.edu	37	chr15	79749968	79749968	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgcagagacctgtgcacctcTggtcagggcaagtacagtga	13	10	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:79749968T>C	uc002bew.1	+	2	1554	c.1479T>C	c.(1477-1479)TCT>TCC	p.S493S	KIAA1024_uc010unk.1_Silent_p.S493S	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	493						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TGTGCACCTCTGGTCAGGGCA	0.532													0	0	0	0.004482	0	8	26										C	79749968	T	C	79749968	2	2	127	1	0	0	0	0	0	0	0	1	8205	1567	55	5		5	KIAA1024	15	79749968	Silent	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	14302650	79749968	22781424	134	37986										
KIAA1199	57214	broad.mit.edu	37	chr15	81199027	81199027	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaccaatgtacctgcacatcGgggaggagatagacggcgtg	14	9	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:81199027G>C	uc002bfw.1	+	12	1695	c.1435G>C	c.(1435-1437)GGG>CGG	p.G479R	KIAA1199_uc010unn.1_Missense_Mutation_p.G479R	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	479										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						CCTGCACATCGGGGAGGAGAT	0.582													0	0	0	0.004656	0	21	53										C	81199027	G	C	81199027	3	2	127	1	0	0	0	0	1	0	0	0	8213	1116	39	4	1477	4	KIAA1199	15	81199027	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1449059	81199027	21332365	135	37987										
WDR93	56964	broad.mit.edu	37	chr15	90272286	90272286	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctatttccttcttcctagctGcctatttgcaatgccaccgg	6	14	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:90272286G>A	uc002boj.2	+	10	1186	c.1085G>A	c.(1084-1086)TGC>TAC	p.C362Y	WDR93_uc010bnr.2_Missense_Mutation_p.C362Y|WDR93_uc010upz.1_Missense_Mutation_p.C79Y	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	362					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTTCCTAGCTGCCTATTTGCA	0.537													0	0	0	0.010818	0	29	76										A	90272286	G	A	90272286	3	1	127	1	0	0	0	0	1	0	0	0	17337	1319	46	2	1119	2	WDR93	15	90272286	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	9073259	90272286	12259106	136	37988										
IQGAP1	8826	broad.mit.edu	37	chr15	90972827	90972827	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttttttttttctaggcgactGgcctccactttagacacact	6	11	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr15:90972827G>A	uc002bpl.1	+	4	420	c.319G>A	c.(319-321)GGC>AGC	p.G107S		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	107	CH.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTAGGCGACTGGCCTCCACTT	0.353													0	0	0	0.00499	0	15	30										A	90972827	G	A	90972827	3	1	127	1	0	0	0	0	1	0	0	0	7814	1348	47	2	333	2	IQGAP1	15	90972827	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	700541	90972827	11558565	137	37989										
BAIAP3	8938	broad.mit.edu	37	chr16	1388576	1388576	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gaccttgctggacattaagaGcagcgtgctcaggcaggtgc	14	10	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:1388576G>A	uc002clk.1	+	2	131	c.131G>A	c.(130-132)AGC>AAC	p.S44N	BAIAP3_uc002clj.2_Missense_Mutation_p.S9N|BAIAP3_uc010uuz.1_Missense_Mutation_p.S9N|BAIAP3_uc010uva.1_Missense_Mutation_p.S9N|BAIAP3_uc010uvb.1_Missense_Mutation_p.S44N|BAIAP3_uc010uvc.1_Missense_Mutation_p.S9N	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	44					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				GACATTAAGAGCAGCGTGCTC	0.672													0	0	0	0.007291	0	27	5										A	1388576	G	A	1388576	3	1	127	1	0	0	0	0	1	0	0	0	1304	971	34	2	137	2	BAIAP3	16	1388576	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		1388576	88966177	138	37990										
ZNF263	10127	broad.mit.edu	37	chr16	3339613	3339613	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggcagagaactggggcgaccGaaggaactgcagccaaagaa	15	9	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:3339613G>A	uc002cuq.2	+	6	1439	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P	ZNF263_uc010uww.1_Silent_p.P17P|ZNF263_uc002cur.2_Silent_p.P17P	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	369					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						TGGGGCGACCGAAGGAACTGC	0.537													0	0	0	0.007413	0	20	33										A	3339613	G	A	3339613	2	1	127	1	0	0	0	0	0	0	0	1	17800	1045	37	1		1	ZNF263	16	3339613	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	1951037	3339613	87015140	139	37991										
PMM2	5373	broad.mit.edu	37	chr16	8906913	8906918	+	In_Frame_Del	DEL	GAAAAT	GAAAAT	-													0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gatactgtctgcgacatgtgGaaaatgacggttataagacc					rs34258285	byFrequency	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:8906913_8906918delGAAAAT	uc002czf.3	+	7	659_664	c.589_594delGAAAAT	c.(589-594)GAAAATdel	p.EN197del	PMM2_uc010uyf.1_RNA|PMM2_uc010uyg.1_In_Frame_Del_p.EN114del|PMM2_uc010uyh.1_In_Frame_Del_p.EN72del|PMM2_uc010buj.2_RNA|PMM2_uc010uyi.1_In_Frame_Del_p.EN50del	NM_000303	NP_000294	O15305	PMM2_HUMAN	phosphomannomutase 2	197_198					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1						GCGACATGTGGAAAATGACGGTTATA	0.471																		18	208	---	---								-	8906918	GAAAAT	-	8906913	7	5	127	1	0	1	0	1	0	0	0	0	12137	1175	41	0	615	0	PMM2	16	8906913	In_Frame_Del	DEL	GAAAAT	TCGA-HQ-A2OE-01A-11D-A202-08	5567300	8906913	81447840	140	37992										
TEKT5	146279	broad.mit.edu	37	chr16	10775971	10775971	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttcgaggtccctctccagcaCgtgctgagcatcccggttat	10	14	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:10775971C>T	uc002czz.1	-	4	814	c.742G>A	c.(742-744)GTG>ATG	p.V248M		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	tektin 5	248					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2						CTCTCCAGCACGTGCTGAGCA	0.552													0	0	0	0.01441	0	70	84										T	10775971	C	T	10775971	3	4	127	1	0	0	0	0	1	0	0	0	15753	536	19	2	731	2	TEKT5	16	10775971	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	1869058	10775971	79578782	141	37993										
HEATR3	55027	broad.mit.edu	37	chr16	50109505	50109505	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	attgtttgcagacagtgactGaggataacccagagctgctg	12	8	0	4			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:50109505G>A	uc002efw.2	+	6	808	c.646G>A	c.(646-648)GAG>AAG	p.E216K	HEATR3_uc002efx.2_Missense_Mutation_p.E130K	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	216							binding			ovary(1)|skin(1)	2						GACAGTGACTGAGGATAACCC	0.383													0	0	0	0.008871	0	19	34										A	50109505	G	A	50109505	3	1	127	1	0	0	0	0	1	0	0	0	7029	1291	45	1	668	1	HEATR3	16	50109505	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	39333534	50109505	40245248	142	37994										
DYNC1LI2	1783	broad.mit.edu	37	chr16	66757722	66757722	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	catttgacaacacagtctttTgtcctgaaaaaaaaaaaaag	5	7	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:66757722T>C	uc002eqb.1	-	13	1413	c.1382A>G	c.(1381-1383)CAA>CGA	p.Q461R	DYNC1LI2_uc010vis.1_Missense_Mutation_p.Q384R	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	461					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		CACAGTCTTTTGTCCTGAAAA	0.333													0	0	0	0.003163	0	14	26										C	66757722	T	C	66757722	3	2	127	1	0	0	0	0	1	0	0	0	4845	1812	63	5	100	5	DYNC1LI2	16	66757722	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	16648217	66757722	23597031	143	37995										
FBXO31	79791	broad.mit.edu	37	chr16	87364973	87364973	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	catctgcgttccggaaggtgGcctggacccggctgtacagg	15	12	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:87364973G>A	uc002fjw.2	-	9	1585	c.1541C>T	c.(1540-1542)GCC>GTC	p.A514V	FBXO31_uc010vot.1_Missense_Mutation_p.A342V|FBXO31_uc002fjv.2_Missense_Mutation_p.A406V	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	514					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		CCGGAAGGTGGCCTGGACCCG	0.617													0	0	0	0.004482	0	8	21										A	87364973	G	A	87364973	3	1	127	1	0	0	0	0	1	0	0	0	5741	1203	42	2	82	2	FBXO31	16	87364973	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	20607251	87364973	2989780	144	37996										
C16orf55	124045	broad.mit.edu	37	chr16	89724678	89724678	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gaggagcaaaagaagggatcCacctattcagttccaaaatc	9	9	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr16:89724678C>T	uc002fnw.1	+	2	57	c.57C>T	c.(55-57)TCC>TCT	p.S19S	CHMP1A_uc002fnu.2_5'Flank|CHMP1A_uc002fnv.2_5'Flank|C16orf55_uc002fnx.3_Silent_p.S20S|C16orf55_uc010vpk.1_Silent_p.S20S|C16orf55_uc002fny.1_Intron	NM_153025	NP_694570	Q96N06	CP055_HUMAN	hypothetical protein LOC124045	19											0		all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		AGAAGGGATCCACCTATTCAG	0.532													0	0	0	0.008291	0	10	37										T	89724678	C	T	89724678	2	4	127	1	0	0	0	0	0	0	0	1	1820	581	21	2		2	C16orf55	16	89724678	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	2359705	89724678	630075	145	37997										
DNAH9	1770	broad.mit.edu	37	chr17	11648245	11648245	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cgggatttcaacatccccaaGattgtgactgatgacatgcc	9	11	1	4			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr17:11648245G>A	uc002gne.2	+	31	6311	c.6243G>A	c.(6241-6243)AAG>AAA	p.K2081K	DNAH9_uc010coo.2_Silent_p.K1375K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2081					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACATCCCCAAGATTGTGACTG	0.597													0	0	0	0.004482	0	8	6										A	11648245	G	A	11648245	2	1	127	1	0	0	0	0	0	0	0	1	4608	933	33	1		1	DNAH9	17	11648245	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		11648245	69546965	146	37998										
KIAA0100	9703	broad.mit.edu	37	chr17	26945872	26945872	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	agctgtccatcttcctctgtCaggcgccaccgtgcctgagc	10	16	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr17:26945872C>G	uc002hbu.2	-	32	5859	c.5760G>C	c.(5758-5760)CTG>CTC	p.L1920L	KIAA0100_uc002hbt.2_Silent_p.L249L	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1920						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTTCCTCTGTCAGGCGCCACC	0.512													0	0	0	0.001984	0	7	114										G	26945872	C	G	26945872	2	3	127	1	0	0	0	0	0	0	0	1	8154	813	29	1		1	KIAA0100	17	26945872	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	15297627	26945872	54249338	147	37999										
ACBD4	79777	broad.mit.edu	37	chr17	43215296	43215296	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gcaggtttggacagagcagcGggcagcatctggaggaaagc	17	8	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr17:43215296G>A	uc002iid.2	+	8	924	c.580G>A	c.(580-582)GGG>AGG	p.G194R	ACBD4_uc010wjj.1_Missense_Mutation_p.G210R|ACBD4_uc002iie.2_Missense_Mutation_p.G210R|ACBD4_uc002iif.2_Missense_Mutation_p.R197Q|ACBD4_uc002iic.2_Missense_Mutation_p.R197Q|ACBD4_uc010dae.2_Missense_Mutation_p.G132R	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	194							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						ACAGAGCAGCGGGCAGCATCT	0.607													0	0	0	0.001984	0	6	51										A	43215296	G	A	43215296	3	1	127	1	0	0	0	0	1	0	0	0	124	1116	39	2	654	2	ACBD4	17	43215296	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	16269424	43215296	37979914	148	38000										
SLC16A6	9120	broad.mit.edu	37	chr17	66270122	66270122	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aacctcttgtgagaaggaggCggccaccatcccggtgctga	13	12	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr17:66270122C>T	uc002jgz.1	-	3	510	c.322G>A	c.(322-324)GCC>ACC	p.A108T	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Missense_Mutation_p.A108T	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	108	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	GAGAAGGAGGCGGCCACCATC	0.542													0	0	0	0.004482	0	9	41										T	66270122	C	T	66270122	3	4	127	1	0	0	0	0	1	0	0	0	14412	768	27	2	1265	2	SLC16A6	17	66270122	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	23054826	66270122	14925088	149	38001										
SOX9	6662	broad.mit.edu	37	chr17	70119895	70119895	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gagtttgaccagtacctgccGcccaacggccacccgggggt	13	15	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr17:70119895G>A	uc002jiw.2	+	3	1269	c.897G>A	c.(895-897)CCG>CCA	p.P299P	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	299					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			AGTACCTGCCGCCCAACGGCC	0.682													0	0	0	0.003163	0	13	61										A	70119895	G	A	70119895	2	1	127	1	0	0	0	0	0	0	0	1	14958	1074	38	2		2	SOX9	17	70119895	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	3849773	70119895	11075315	150	38002										
GALR2	8811	broad.mit.edu	37	chr17	74073059	74073059	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aagcgcaaggtgacacgcatGatcctcatcgtggccgcgct	12	13	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr17:74073059G>A	uc002jqm.1	+	2	792	c.711G>A	c.(709-711)ATG>ATA	p.M237I	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	237	Cytoplasmic (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						TGACACGCATGATCCTCATCG	0.706													0	0	0	0.005443	0	26	20										A	74073059	G	A	74073059	3	1	127	1	0	0	0	0	1	0	0	0	6228	1290	45	1	717	1	GALR2	17	74073059	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	3953164	74073059	7122151	151	38003										
DENND1C	79958	broad.mit.edu	37	chr19	6468350	6468350	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atgctaagactgtccagaatCtcgctcaacaaatccagttc	6	12	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:6468350C>G	uc002mfe.2	-	22	1778	c.1686G>C	c.(1684-1686)GAG>GAC	p.E562D	DENND1C_uc002mfb.2_Missense_Mutation_p.E112D|DENND1C_uc002mfc.2_Missense_Mutation_p.E112D|DENND1C_uc002mfd.2_Missense_Mutation_p.E112D|DENND1C_uc010xje.1_Missense_Mutation_p.E518D	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	562						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						TGTCCAGAATCTCGCTCAACA	0.577													0	0	0	0.00308	0	7	14										G	6468350	C	G	6468350	3	3	127	1	0	0	0	0	1	0	0	0	4428	912	32	1	727	1	DENND1C	19	6468350	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		6468350	52660633	152	38004										
TYK2	7297	broad.mit.edu	37	chr19	10477209	10477209	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggtggatctcctcctcggtCgacagctcccacagtgatgc	11	14	1	1	rs55988893		TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:10477209C>T	uc002moc.3	-	6	891	c.513G>A	c.(511-513)TCG>TCA	p.S171S	TYK2_uc010dxe.2_5'UTR|TYK2_uc002mod.2_Silent_p.S171S	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	171	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCTCCTCGGTCGACAGCTCCC	0.557													0	0	0	0.01441	0	40	141										T	10477209	C	T	10477209	2	4	127	1	0	0	0	0	0	0	0	1	16807	871	31	1		1	TYK2	19	10477209	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	4008859	10477209	48651774	153	38005										
S1PR5	53637	broad.mit.edu	37	chr19	10624779	10624779	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttggtgagcgtgtagatgatGgggttcagaagtgagttggc	18	3	1	5			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:10624779G>A	uc002mot.1	-	2	966	c.909C>T	c.(907-909)CCC>CCT	p.P303P	S1PR5_uc002mou.1_Silent_p.P303P	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	303	Helical; Name=7; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						TGTAGATGATGGGGTTCAGAA	0.672													0	0	0	0.010729	0	11	35										A	10624779	G	A	10624779	2	1	127	1	0	0	0	0	0	0	0	1	13797	1335	47	2		2	S1PR5	19	10624779	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	147570	10624779	48504204	154	38006										
CARM1	10498	broad.mit.edu	37	chr19	11031350	11031350	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cgcagacagagctacgacatCagtattgtggcccaggtgga	13	10	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:11031350C>T	uc002mpz.2	+	12	1476	c.1350C>T	c.(1348-1350)ATC>ATT	p.I450I	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Silent_p.I233I	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	450					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						GCTACGACATCAGTATTGTGG	0.622													0	0	0	0.010504	0	19	62										T	11031350	C	T	11031350	2	4	127	1	0	0	0	0	0	0	0	1	2655	816	29	1		1	CARM1	19	11031350	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	406571	11031350	48097633	155	38007										
RGL3	57139	broad.mit.edu	37	chr19	11526625	11526625	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cccctcacctgtccacacctGaggcggctcctcttcctgct	7	20	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:11526625G>A	uc002mrp.2	-	5	689	c.625C>T	c.(625-627)CAG>TAG	p.Q209*	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Nonsense_Mutation_p.Q209*	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	209					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						GTCCACACCTGAGGCGGCTCC	0.572													0	0	0	0.01441	0	116	162										A	11526625	G	A	11526625	4	1	127	1	0	0	0	0	0	1	0	0	13278	1299	45	1	1585	1	RGL3	19	11526625	Nonsense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	495275	11526625	47602358	156	38008										
ZNF20	7568	broad.mit.edu	37	chr19	12243475	12243475	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	taaaggctttgccacattgcTtgcattgatagggtttctct	9	8	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:12243475T>C	uc002mtf.1	-	4	1669	c.1526A>G	c.(1525-1527)AAG>AGG	p.K509R	ZNF20_uc002mte.1_Missense_Mutation_p.K474R|ZNF20_uc002mtg.1_Missense_Mutation_p.K509R	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	509	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCACATTGCTTGCATTGATA	0.403													0	0	0	0.01441	0	98	121										C	12243475	T	C	12243475	3	2	127	1	0	0	0	0	1	0	0	0	17758	1609	56	5	76	5	ZNF20	19	12243475	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	716850	12243475	46885508	157	38009										
COMP	1311	broad.mit.edu	37	chr19	18896513	18896513	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	accacccagttggggtcaatCtgcgcgtcaccctccgggtc	11	16	3	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:18896513C>T	uc002nke.2	-	14	1674	c.1638G>A	c.(1636-1638)CAG>CAA	p.Q546Q	COMP_uc002nkd.2_Silent_p.Q513Q|COMP_uc010xqj.1_Silent_p.Q493Q	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	546	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						TGGGGTCAATCTGCGCGTCAC	0.622													0	0	0	0.006214	0	9	58										T	18896513	C	T	18896513	2	4	127	1	0	0	0	0	0	0	0	1	3724	912	32	1		1	COMP	19	18896513	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	6653038	18896513	40232470	158	38010										
PRX	57716	broad.mit.edu	37	chr19	40909734	40909734	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ccggtctgcgcctccgtctcCacgataatttccaccaactc	6	18	2	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:40909734C>T	uc002onr.2	-	5	332	c.63G>A	c.(61-63)GTG>GTA	p.V21V	PRX_uc002onq.2_5'UTR|PRX_uc002ons.2_Silent_p.V21V	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	21	PDZ.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCTCCGTCTCCACGATAATTT	0.682													0	0	0	0.004672	0	3	11										T	40909734	C	T	40909734	2	4	127	1	0	0	0	0	0	0	0	1	12642	581	21	2		2	PRX	19	40909734	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	22013221	40909734	18219249	159	38011										
KLK15	55554	broad.mit.edu	37	chr19	51329977	51329977	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aagatgtgtccgagataatgCtgatgttggcacaatgcaac	11	7	0	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:51329977C>G	uc002ptl.2	-	4	549	c.518G>C	c.(517-519)AGC>ACC	p.S173T	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Intron|KLK15_uc002pto.2_Missense_Mutation_p.S172T|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Intron|KLK15_uc010eod.2_Intron	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	173	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CGAGATAATGCTGATGTTGGC	0.562													0	0	0	0.005443	0	25	145										G	51329977	C	G	51329977	3	3	127	1	0	0	0	0	1	0	0	0	8403	797	28	4	260	4	KLK15	19	51329977	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	10420243	51329977	7799006	160	38012										
NLRP7	199713	broad.mit.edu	37	chr19	55450851	55450851	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtctccgtccaggaacagacGgaggtcggactcctgcaccc	12	15	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:55450851G>A	uc002qih.3	-	4	1412	c.1336C>T	c.(1336-1338)CGT>TGT	p.R446C	NLRP7_uc002qig.3_Missense_Mutation_p.R446C|NLRP7_uc002qii.3_Missense_Mutation_p.R446C|NLRP7_uc010esk.2_Missense_Mutation_p.R446C|NLRP7_uc010esl.2_Missense_Mutation_p.R474C	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	446	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		AGGAACAGACGGAGGTCGGAC	0.632													0	0	0	0.012319	0	20	57										A	55450851	G	A	55450851	3	1	127	1	0	0	0	0	1	0	0	0	10482	1116	39	2	1809	2	NLRP7	19	55450851	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	4120874	55450851	3678132	161	38013										
NLRP13	126204	broad.mit.edu	37	chr19	56424636	56424636	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cagtagttcagccttcatgtTctctctgtattttcttctgt	6	10	6	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr19:56424636T>A	uc010ygg.1	-	5	572	c.547A>T	c.(547-549)AAC>TAC	p.N183Y		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	183							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GCCTTCATGTTCTCTCTGTAT	0.418													0	0	0	0.003163	0	13	84										A	56424636	T	A	56424636	3	1	127	1	0	0	0	0	1	0	0	0	10475	1783	62	5	2610	5	NLRP13	19	56424636	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	973785	56424636	2704347	162	38014										
HCK	3055	broad.mit.edu	37	chr20	30674544	30674544	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	aaactctgcagcatgacaagCtggtcaaacttcatgcggtg	10	10	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:30674544C>T	uc002wxh.2	+	9	1120	c.949C>T	c.(949-951)CTG>TTG	p.L317L	HCK_uc010gdy.2_Silent_p.L296L|HCK_uc002wxi.2_Silent_p.L295L	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	317	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCATGACAAGCTGGTCAAACT	0.582													0	0	0	0.01441	0	75	15										T	30674544	C	T	30674544	2	4	127	1	0	0	0	0	0	0	0	1	6994	796	28	2		2	HCK	20	30674544	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		30674544	32350976	163	38015										
GGT7	2686	broad.mit.edu	37	chr20	33442618	33442618	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cctctgccacccagtgaagaGcctgttctcgggataccagg	11	14	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:33442618G>A	uc002xay.2	-	9	1254	c.1211C>T	c.(1210-1212)GCT>GTT	p.A404V	GGT7_uc002xaz.1_Missense_Mutation_p.A421V	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	404	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						CCAGTGAAGAGCCTGTTCTCG	0.567													0	0	0	0.00308	0	7	94										A	33442618	G	A	33442618	3	1	127	1	0	0	0	0	1	0	0	0	6364	971	34	2	805	2	GGT7	20	33442618	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	2768074	33442618	29582902	164	38016										
SERINC3	10955	broad.mit.edu	37	chr20	43133481	43133481	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tgaccaggtgaggtacatagTgtagagggtgatgagggagg	19	3	0	5			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:43133481T>C	uc002xme.2	-	7	969	c.835A>G	c.(835-837)ACT>GCT	p.T279A	SERINC3_uc002xmf.1_Missense_Mutation_p.T279A|SERINC3_uc010ggs.1_Missense_Mutation_p.T272A|SERINC3_uc010zwp.1_Missense_Mutation_p.T224A	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	279	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGGTACATAGTGTAGAGGGTG	0.478													0	0	0	0.00308	0	7	49										C	43133481	T	C	43133481	3	2	127	1	0	0	0	0	1	0	0	0	14081	1696	59	5	602	5	SERINC3	20	43133481	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	9690863	43133481	19892039	165	38017										
MATN4	8785	broad.mit.edu	37	chr20	43929794	43929794	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tggccctctctgcagtggcaCcgtggcccaccaggggtgct	14	15	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:43929794C>A	uc002xnn.2	-	5	1024	c.837G>T	c.(835-837)CGG>CGT	p.R279R	MATN4_uc002xno.2_Silent_p.R238R|MATN4_uc002xnp.2_Intron|MATN4_uc010zwr.1_Silent_p.R227R|MATN4_uc002xnr.1_Silent_p.R279R	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	320	EGF-like 3.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				TGCAGTGGCACCGTGGCCCAC	0.557											OREG0025977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.49906e-05	0.00245	1.55075e-05	14	94										A	43929794	C	A	43929794	2	1	127	1	0	0	0	0	0	0	0	1	9336	494	18	4		4	MATN4	20	43929794	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	796313	43929794	19095726	166	38018										
CEBPB	1051	broad.mit.edu	37	chr20	48807640	48807640	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cgccgcctgcctttaaatccAtggaagtggccaacttctac	8	14	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:48807640A>G	uc002xvi.1	+	1	265	c.70A>G	c.(70-72)ATG>GTG	p.M24V	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	24	Required for Lys-174 sumoylation.				acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			CTTTAAATCCATGGAAGTGGC	0.537													0	0	0	0.009096	0	3	26										G	48807640	A	G	48807640	3	3	127	1	0	0	0	0	1	0	0	0	3200	217	8	5	72	5	CEBPB	20	48807640	Missense_Mutation	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08	4877846	48807640	14217880	167	38019										
LSM14B	149986	broad.mit.edu	37	chr20	60706547	60706547	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gttcttcgacaacatctcttCtgaactcaagaccaggtgag	8	11	4	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:60706547C>T	uc010gjy.1	+	7	1177	c.971C>T	c.(970-972)TCT>TTT	p.S324F	LSM14B_uc002ybv.2_Missense_Mutation_p.S298F|LSM14B_uc010zzz.1_Missense_Mutation_p.S244F	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	324	FFD box.				multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			AACATCTCTTCTGAACTCAAG	0.552													0	0	0	0.009096	0	3	39										T	60706547	C	T	60706547	3	4	127	1	0	0	0	0	1	0	0	0	9055	913	32	1	997	1	LSM14B	20	60706547	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	11898907	60706547	2318973	168	38020										
COL9A3	1299	broad.mit.edu	37	chr20	61458604	61458604	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cctttccagggtgaccgaggCgagaggggcccagaagggtt	17	10	0	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr20:61458604C>T	uc002ydm.2	+	16	807	c.804C>T	c.(802-804)GGC>GGT	p.G268G		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	268	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					GTGACCGAGGCGAGAGGGGCC	0.632													0	0	0	0.004482	0	8	56										T	61458604	C	T	61458604	2	4	127	1	0	0	0	0	0	0	0	1	3709	755	27	2		2	COL9A3	20	61458604	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	752057	61458604	1566916	169	38021										
RWDD2B	10069	broad.mit.edu	37	chr21	30380277	30380277	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	caactgactggactgtgcttCctgtggtgggtgaagatgaa	14	7	0	4			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr21:30380277C>A	uc002yms.2	-	4	617	c.530G>T	c.(529-531)GGA>GTA	p.G177V	RWDD2B_uc002ymt.2_Missense_Mutation_p.G148V|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.G97V	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	177											0						GACTGTGCTTCCTGTGGTGGG	0.443													1	0	2.21704e-12	0.00278	2.41232e-12	23	64										A	30380277	C	A	30380277	3	1	127	1	0	0	0	0	1	0	0	0	13756	855	30	3	437	3	RWDD2B	21	30380277	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		30380277	17749618	170	38022										
KRTAP10-2	386679	broad.mit.edu	37	chr21	45971299	45971299	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtcgtccacctgccaggagtTggtgcaggcgctggagcaga	16	11	0	1	rs233240	by1000genomes	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr21:45971299T>C	uc002zfi.1	-	1	90	c.43A>G	c.(43-45)AAC>GAC	p.N15D	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	15						keratin filament		p.N15D(1)		large_intestine(1)	1						TGCCAGGAGTTGGTGCAGGCG	0.597													0	0	0	0.001168	0	5	88										C	45971299	T	C	45971299	3	2	127	1	0	0	0	0	1	0	0	0	8509	1812	63	5	728	5	KRTAP10-2	21	45971299	Missense_Mutation	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	15591022	45971299	2158596	171	38023										
ITGB2	3689	broad.mit.edu	37	chr21	46314945	46314945	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtcctcagacagctcccccaCggctgacttggggatgatct	11	14	2	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr21:46314945C>T	uc002zgd.2	-	8	1068	c.1024G>A	c.(1024-1026)GTG>ATG	p.V342M	ITGB2_uc002zge.2_Missense_Mutation_p.V342M|ITGB2_uc002zgf.3_Missense_Mutation_p.V342M|ITGB2_uc011afl.1_Missense_Mutation_p.V264M|ITGB2_uc010gpw.2_Missense_Mutation_p.V285M|ITGB2_uc002zgg.2_Missense_Mutation_p.V342M	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	342	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	AGCTCCCCCACGGCTGACTTG	0.577													0	0	0	0.006122	0	18	26										T	46314945	C	T	46314945	3	4	127	1	0	0	0	0	1	0	0	0	7894	536	19	2	1317	2	ITGB2	21	46314945	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	343646	46314945	1814950	172	38024										
SNAP29	9342	broad.mit.edu	37	chr22	21224644	21224644	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggagctcgcccgtcagcgagGagtcctggagcgcacagaga	16	12	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr22:21224644G>C	uc011ahw.1	+	2	364	c.257G>C	c.(256-258)GGA>GCA	p.G86A		NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	86	Potential.				cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			CGTCAGCGAGGAGTCCTGGAG	0.557													0	0	0	0.008871	0	20	102										C	21224644	G	C	21224644	3	2	127	1	0	0	0	0	1	0	0	0	14831	1174	41	1	263	1	SNAP29	22	21224644	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08		21224644	30079922	173	38025										
SEC14L3	266629	broad.mit.edu	37	chr22	30858094	30858094	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ttggttaaacatttggggttCccatctgggtcagtcagggt	13	7	3	0	rs146711095		TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chr22:30858094C>T	uc003ahy.2	-	9	839	c.750G>A	c.(748-750)GGG>GGA	p.G250G	SEC14L3_uc003ahz.2_Silent_p.G173G|SEC14L3_uc003aia.2_Silent_p.G191G|SEC14L3_uc003aib.2_Silent_p.G191G	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	250						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	ATTTGGGGTTCCCATCTGGGT	0.483													0	0	0	0.000602	0	5	34										T	30858094	C	T	30858094	2	4	127	1	0	0	0	0	0	0	0	1	13983	842	30	1		1	SEC14L3	22	30858094	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	9633450	30858094	20446472	174	38026										
IL3RA	3563	broad.mit.edu	37	chrX	1471230	1471230	+	Nonsense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cgcagcaggcgtcaacagtaCgagtgtcttcactacaaaac	9	12	3	0	rs147935693		TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:1471230C>G	uc004cps.2	+	6	796	c.447C>G	c.(445-447)TAC>TAG	p.Y149*	IL3RA_uc011mhd.1_Nonsense_Mutation_p.Y71*	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	149	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GTCAACAGTACGAGTGTCTTC	0.602													0	0	0	0.01441	0	54	524										G	1471230	C	G	1471230	4	3	127	1	0	0	0	0	0	1	0	0	7695	547	19	4	465	4	IL3RA	23	1471230	Nonsense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08		1471230	153799330	175	38027										
DMD	1756	broad.mit.edu	37	chrX	32503148	32503148	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggtccttgtcctttctctttCagggctatgctttgaatttt	8	9	2	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:32503148C>T	uc004dda.1	-	21	2935	c.2691G>A	c.(2689-2691)CTG>CTA	p.L897L	DMD_uc004dcz.2_Silent_p.L774L|DMD_uc004dcy.1_Silent_p.L893L|DMD_uc004ddb.1_Silent_p.L889L|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	897	Spectrin 5.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTTTCTCTTTCAGGGCTATGC	0.413													0	0	0	0.00308	0	7	31										T	32503148	C	T	32503148	2	4	127	1	0	0	0	0	0	0	0	1	4580	813	29	1		1	DMD	23	32503148	Silent	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	31031918	32503148	122767412	176	38028										
WAS	7454	broad.mit.edu	37	chrX	48547079	48547079	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gccgcccccaccgccatctcGaggagggaaccagctccccc	10	21	1	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:48547079G>C	uc004dkm.3	+	10	1019	c.962G>C	c.(961-963)CGA>CCA	p.R321P		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	321					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				CCGCCATCTCGAGGAGGGAAC	0.522			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				0	0	0	0.010729	0	9	53										C	48547079	G	C	48547079	3	2	127	1	0	0	0	0	1	0	0	0	17248	1058	37	1	1000	1	WAS	23	48547079	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	16043931	48547079	106723481	177	38029										
KDM5C	8242	broad.mit.edu	37	chrX	53247478	53247478	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	tttgctgagactgtagaggtCcaagatccgccgttctacat	10	10	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:53247478C>T	uc004drz.2	-	3	864	c.331G>A	c.(331-333)GAC>AAC	p.D111N	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Intron|KDM5C_uc004dsa.2_Missense_Mutation_p.D111N	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	111	ARID.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						CTGTAGAGGTCCAAGATCCGC	0.488			N|F|S		clear cell renal carcinoma								0	0	0	0.006214	0	10	50										T	53247478	C	T	53247478	3	4	127	1	0	0	0	0	1	0	0	0	8135	855	30	1	4545	1	KDM5C	23	53247478	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	4700399	53247478	102023082	178	38030										
WNK3	65267	broad.mit.edu	37	chrX	54276034	54276034	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ctatagtgagcaatgtgtccCgtgatatttccttattactt	7	8	0	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:54276034C>T	uc004dtd.1	-	17	3186	c.2747G>A	c.(2746-2748)CGG>CAG	p.R916Q	WNK3_uc004dtc.1_Missense_Mutation_p.R916Q	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	916					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CAATGTGTCCCGTGATATTTC	0.398													0	0	0	0.006214	0	8	78										T	54276034	C	T	54276034	3	4	127	1	0	0	0	0	1	0	0	0	17376	652	23	2	2687	2	WNK3	23	54276034	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	1028556	54276034	100994526	179	38031										
MTMR8	55613	broad.mit.edu	37	chrX	63548760	63548760	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gaaccaagaaaggccacacaGaatgtgttttctcatagact	8	9	1	3			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:63548760G>A	uc004dvs.2	-	12	1441	c.1373C>T	c.(1372-1374)TCT>TTT	p.S458F	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	458	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AGGCCACACAGAATGTGTTTT	0.403													0	0	0	0.000602	0	5	5										A	63548760	G	A	63548760	3	1	127	1	0	0	0	0	1	0	0	0	9949	942	33	1	753	1	MTMR8	23	63548760	Missense_Mutation	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	9272726	63548760	91721800	180	38032										
RLIM	51132	broad.mit.edu	37	chrX	73811938	73811938	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gtcattatctgccttaacatGgtctgaattgcaacagatgt	8	8	3	2	rs61754468	by1000genomes	TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:73811938G>C	uc004ebu.2	-	5	1502	c.1212C>G	c.(1210-1212)ACC>ACG	p.T404T	RLIM_uc004ebw.2_Silent_p.T404T	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	404					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GCCTTAACATGGTCTGAATTG	0.413													0	0	0	0.000602	0	5	65										C	73811938	G	C	73811938	2	2	127	1	0	0	0	0	0	0	0	1	13390	1335	47	4		4	RLIM	23	73811938	Silent	SNP	G	TCGA-HQ-A2OE-01A-11D-A202-08	10263178	73811938	81458622	181	38033										
TGIF2LX	90316	broad.mit.edu	37	chrX	89177629	89177629	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggagtcggcccctagccagaAgctcaccggaatagcccagc	12	15	1	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:89177629A>T	uc004efe.2	+	2	594	c.545A>T	c.(544-546)AAG>ATG	p.K182M		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCTAGCCAGAAGCTCACCGGA	0.562													0	0	0	0.001984	0	7	22										T	89177629	A	T	89177629	3	4	127	1	0	0	0	0	1	0	0	0	15824	72	3	5	547	5	TGIF2LX	23	89177629	Missense_Mutation	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08	15365691	89177629	66092931	182	38034										
GPRASP2	114928	broad.mit.edu	37	chrX	101970046	101970046	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gaggtccaagtaatgggtggTgcaagacccaaaacggaggc	15	8	0	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:101970046T>G	uc004ejk.2	+	4	1583	c.249T>G	c.(247-249)GGT>GGG	p.G83G	GPRASP2_uc004ejl.2_Silent_p.G83G|GPRASP2_uc004ejm.2_Silent_p.G83G|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	83						cytoplasm	protein binding			ovary(1)	1						TAATGGGTGGTGCAAGACCCA	0.562													0	0	0	0.009096	0	4	58										G	101970046	T	G	101970046	2	3	127	1	0	0	0	0	0	0	0	1	6723	1683	59	5		5	GPRASP2	23	101970046	Silent	SNP	T	TCGA-HQ-A2OE-01A-11D-A202-08	12792417	101970046	53300514	183	38035										
IGSF1	3547	broad.mit.edu	37	chrX	130409595	130409595	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	cgtcattactggtggatcccCagagctgcattgaagtggct	12	10	1	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:130409595C>A	uc004ewd.2	-	16	3279	c.3041G>T	c.(3040-3042)TGG>TTG	p.W1014L	IGSF1_uc004ewe.3_Missense_Mutation_p.W1008L|IGSF1_uc004ewf.2_Missense_Mutation_p.W994L	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1014	Extracellular (Potential).|Ig-like C2-type 10.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						GGTGGATCCCCAGAGCTGCAT	0.537													1	0	4.68919e-08	0.008291	4.99863e-08	11	64										A	130409595	C	A	130409595	3	1	127	1	0	0	0	0	1	0	0	0	7596	595	21	4	989	4	IGSF1	23	130409595	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	28439549	130409595	24860965	184	38036										
GPR112	139378	broad.mit.edu	37	chrX	135441568	135441568	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	ggaaacttcacacaagatcaAttgacgttattagtaaactg	7	7	2	2			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:135441568A>G	uc004ezu.1	+	11	7389	c.7098A>G	c.(7096-7098)CAA>CAG	p.Q2366Q	GPR112_uc010nsb.1_Silent_p.Q2161Q|GPR112_uc010nsc.1_Intron	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2366	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CACAAGATCAATTGACGTTAT	0.343													0	0	0	0.004672	0	3	41										G	135441568	A	G	135441568	2	3	127	1	0	0	0	0	0	0	0	1	6629	98	4	5		5	GPR112	23	135441568	Silent	SNP	A	TCGA-HQ-A2OE-01A-11D-A202-08	5031973	135441568	19828992	185	38037										
CTAG2	30848	broad.mit.edu	37	chrX	153880682	153880682	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	gggtgttctgagatctctagCtttctgcccctccggggagg	14	11	3	1			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:153880682C>G	uc004fmi.1	-	2	546	c.493G>C	c.(493-495)GCT>CCT	p.A165P	CTAG2_uc004fmh.1_Intron	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	165						centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGATCTCTAGCTTTCTGCCCC	0.632													0	0	0	0.009718	0	43	10										G	153880682	C	G	153880682	3	3	127	1	0	0	0	0	1	0	0	0	3991	797	28	4	282	4	CTAG2	23	153880682	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	18439114	153880682	1389878	186	38038			1	176		2	2	13	C		7.248576e-05
CTAG2	30848	broad.mit.edu	37	chrX	153880694	153880694	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.288770053475936	54	7.16503073390359e-12	2.68898132161356	3.6304066480485	2.10197494160119	0.853510194927012	0.932406095298416	34	atctctagctttctgcccctCcggggaggcggatcccagcc	11	16	2	0			TCGA-HQ-A2OE-01A-11D-A202-08	TCGA-HQ-A2OE-10A-01D-A202-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61324839-e90a-49f2-a9c9-629d7b125fe9	af92ee60-ca4f-4396-b0ff-b4b8c0ee0bb4	g.chrX:153880694C>T	uc004fmi.1	-	2	534	c.481G>A	c.(481-483)GAG>AAG	p.E161K	CTAG2_uc004fmh.1_Intron	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	161						centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTCTGCCCCTCCGGGGAGGCG	0.632													0	0	0	0.010771	0	45	10										T	153880694	C	T	153880694	3	4	127	1	0	0	0	0	1	0	0	0	3991	864	30	1	294	1	CTAG2	23	153880694	Missense_Mutation	SNP	C	TCGA-HQ-A2OE-01A-11D-A202-08	12	153880694	1389866	187	38039			1	176		2	2	13	C		7.248576e-05
GLTPD1	80772	broad.mit.edu	37	chr1	1262843	1262843	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgcgcctgcaccgcgccctGcactggctgcagctgttcct	11	18	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:1262843G>A	uc001aeo.2	+	3	760	c.345G>A	c.(343-345)CTG>CTA	p.L115L	CPSF3L_uc001aee.1_5'Flank|CPSF3L_uc001aef.1_5'Flank|CPSF3L_uc009vjz.1_5'Flank|CPSF3L_uc010nyj.1_5'Flank|CPSF3L_uc001aeg.1_5'Flank|CPSF3L_uc001aeh.1_5'Flank|CPSF3L_uc001aei.1_5'Flank|CPSF3L_uc001aej.1_5'Flank|CPSF3L_uc001aek.1_5'Flank|CPSF3L_uc001aem.1_5'Flank|CPSF3L_uc001ael.1_5'Flank|CPSF3L_uc001aen.1_5'Flank	NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	115						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACCGCGCCCTGCACTGGCTGC	0.726													0	0	0	0.004672	0	3	10										A	1262843	G	A	1262843	2	1	128	1	0	0	0	0	0	0	0	1	6472	1306	46	2		2	GLTPD1	1	1262843	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		1262843	247987778	1	38040										
H6PD	9563	broad.mit.edu	37	chr1	9323690	9323690	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcaagaaccaggcctgctgtGtgcagagcgaaaagcactgg	13	10	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:9323690G>A	uc001apt.2	+	5	1411	c.1138G>A	c.(1138-1140)GTG>ATG	p.V380M		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	380	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GGCCTGCTGTGTGCAGAGCGA	0.642													0	0	0	0.001984	0	7	74										A	9323690	G	A	9323690	3	1	128	1	0	0	0	0	1	0	0	0	6936	1377	48	2	1152	2	H6PD	1	9323690	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	8060847	9323690	239926931	2	38041										
MRTO4	51154	broad.mit.edu	37	chr1	19584361	19584361	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acacagaaatggactacgccCgagctggtaacaaagcagct	10	11	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:19584361C>T	uc001bbs.2	+	6	631	c.376C>T	c.(376-378)CGA>TGA	p.R126*		NM_016183	NP_057267	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog	126					ribosome biogenesis	nuclear membrane|nucleolus					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGACTACGCCCGAGCTGGTAA	0.587													0	0	0	0.007413	0	19	99										T	19584361	C	T	19584361	4	4	128	1	0	0	0	0	0	1	0	0	9852	644	23	2	398	2	MRTO4	1	19584361	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	10260671	19584361	229666260	3	38042										
IL28RA	163702	broad.mit.edu	37	chr1	24483775	24483775	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccagcagaaggtcagtgtctGaagagaaactgggggtcccc	14	10	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:24483775G>A	uc001bis.2	-	7	1421	c.1408C>T	c.(1408-1410)CAG>TAG	p.Q470*	IL28RA_uc001bir.2_Nonsense_Mutation_p.Q441*|IL28RA_uc001bit.2_3'UTR|IL28RA_uc001biu.2_Nonsense_Mutation_p.Q386*	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	470	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		GTCAGTGTCTGAAGAGAAACT	0.612													0	0	0	0.013537	0	13	76										A	24483775	G	A	24483775	4	1	128	1	0	0	0	0	0	1	0	0	7684	1299	45	1	158	1	IL28RA	1	24483775	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4899414	24483775	224766846	4	38043										
PPP1R8	5511	broad.mit.edu	37	chr1	28176864	28176864	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctgcaccaaaccctgcagtCtataaccctgaagctgtaaa	6	14	1	1	rs144281839	byFrequency	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:28176864C>G	uc001bov.1	+	7	1017	c.963C>G	c.(961-963)GTC>GTG	p.V321V	PPP1R8_uc001bow.1_Silent_p.V179V|PPP1R8_uc001box.1_Silent_p.V97V|PPP1R8_uc009vtc.1_RNA|PPP1R8_uc009vtd.1_RNA	NM_014110	NP_054829	Q12972	PP1R8_HUMAN	protein phosphatase 1 regulatory inhibitor	321	Interaction with EED.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding				0		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCTGCAGTCTATAACCCTG	0.488													0	0	0	0.004482	0	9	85										G	28176864	C	G	28176864	2	3	128	1	0	0	0	0	0	0	0	1	12377	900	32	1		1	PPP1R8	1	28176864	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3693089	28176864	221073757	5	38044										
TINAGL1	64129	broad.mit.edu	37	chr1	32051353	32051353	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	taccttgacatctgcccacaGccctcatggaggtgcatgag	10	13	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:32051353G>A	uc001bta.2	+	10	1220	c.1094_splice	c.e10-1	p.A365_splice	TINAGL1_uc001bsz.2_Splice_Site_p.A220_splice|TINAGL1_uc010ogj.1_Splice_Site_p.A334_splice|TINAGL1_uc010ogk.1_Splice_Site_p.A365_splice	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1						endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		TCTGCCCACAGCCCTCATGGA	0.597													0	0	0	0.000602	0	5	18										A	32051353	G	A	32051353	5	1	128	1	0	0	0	0	0	0	1	0	15919	985	34	2	1127	2	TINAGL1	1	32051353	Splice_Site	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3874489	32051353	217199268	6	38045										
KHDRBS1	10657	broad.mit.edu	37	chr1	32503563	32503563	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgtgaggggtgctccagcaCcaagagcacggacagcgggc	16	12	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:32503563C>G	uc001bub.2	+	6	1139	c.1033C>G	c.(1033-1035)CCA>GCA	p.P345A	KHDRBS1_uc001bua.1_Missense_Mutation_p.P306A|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	345	Pro-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGCTCCAGCACCAAGAGCACG	0.542													0	0	0	0.006214	0	10	108										G	32503563	C	G	32503563	3	3	128	1	0	0	0	0	1	0	0	0	8146	507	18	4	1055	4	KHDRBS1	1	32503563	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	452210	32503563	216747058	7	38046										
FAM167B	84734	broad.mit.edu	37	chr1	32713099	32713099	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggagggggagagcctggactCtgtgaaggcactgacagcca	17	9	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:32713099C>T	uc001buw.2	+	1	282	c.77C>T	c.(76-78)TCT>TTT	p.S26F		NM_032648	NP_116037	Q9BTA0	F167B_HUMAN	hypothetical protein LOC84734	26										ovary(1)	1						AGCCTGGACTCTGTGAAGGCA	0.622													0	0	0	0.003163	0	15	30										T	32713099	C	T	32713099	3	4	128	1	0	0	0	0	1	0	0	0	5484	913	32	1	79	1	FAM167B	1	32713099	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	209536	32713099	216537522	8	38047										
EIF2C4	192670	broad.mit.edu	37	chr1	36301437	36301437	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aataaattatttttgtagcgGaggtgaaacgtgttggagat	12	2	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:36301437G>C	uc001bzj.1	+	13	1757	c.1567G>C	c.(1567-1569)GAG>CAG	p.E523Q		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	523	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ttttGTAGCGGAGGTGAAACG	0.363													0	0	0	0.001168	0	6	38										C	36301437	G	C	36301437	3	2	128	1	0	0	0	0	1	0	0	0	5008	1175	41	1	1617	1	EIF2C4	1	36301437	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3588338	36301437	212949184	9	38048										
EIF2C4	192670	broad.mit.edu	37	chr1	36301505	36301505	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtccaggtaaaaaatgtagtGaagacctcacctcaaaccct	7	11	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:36301505G>A	uc001bzj.1	+	13	1825	c.1635G>A	c.(1633-1635)GTG>GTA	p.V545V		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	545	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAATGTAGTGAAGACCTCAC	0.388													0	0	0	0.008291	0	9	67										A	36301505	G	A	36301505	2	1	128	1	0	0	0	0	0	0	0	1	5008	1277	45	1		1	EIF2C4	1	36301505	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	68	36301505	212949116	10	38049										
KIAA0754	643314	broad.mit.edu	37	chr1	39876004	39876004	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gctgcctggggaaaggagagGaggaggatggctacatagag	19	5	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:39876004G>T	uc009vvt.1	+	1	829	c.67G>T	c.(67-69)GAG>TAG	p.E23*	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	Error:Variant_position_missing_in_O94854_after_alignment											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAAGGAGAGGAGGAGGATGG	0.463													1	0	3.09899e-07	0.004482	3.47121e-07	7	35										T	39876004	G	T	39876004	4	4	128	1	0	0	0	0	0	1	0	0	8192	1175	41	3	69	3	KIAA0754	1	39876004	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3574499	39876004	209374617	11	38050										
MOBKL2C	148932	broad.mit.edu	37	chr1	47078790	47078790	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tagatgaggttgatgcggttGaagaagtccaccacgtgcac	13	8	0	5			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:47078790G>C	uc001cqf.3	-	2	435	c.204C>G	c.(202-204)TTC>TTG	p.F68L	MKNK1_uc010omf.1_Intron|MOBKL2C_uc001cqe.3_Missense_Mutation_p.F120L	NM_201403	NP_958805	Q70IA8	MOL2C_HUMAN	MOB1, Mps One Binder kinase activator-like 2C	68							metal ion binding			pancreas(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGATGCGGTTGAAGAAGTCCA	0.652													0	0	0	0.001984	0	7	27										C	47078790	G	C	47078790	3	2	128	1	0	0	0	0	1	0	0	0	9686	1281	45	1	458	1	MOBKL2C	1	47078790	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	7202786	47078790	202171831	12	38051										
NFIA	4774	broad.mit.edu	37	chr1	61869892	61869892	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	accctcaggagacgctgaaaGaatttgtccaacttgtctgc	9	11	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:61869892G>C	uc001czw.2	+	8	1676	c.1192G>C	c.(1192-1194)GAA>CAA	p.E398Q	NFIA_uc001czy.2_Missense_Mutation_p.E390Q|NFIA_uc010oos.1_Missense_Mutation_p.E443Q|NFIA_uc001czv.2_Missense_Mutation_p.E398Q|NFIA_uc001czx.2_Missense_Mutation_p.E46Q|NFIA_uc009wae.2_5'Flank	NM_001134673	NP_001128145	Q12857	NFIA_HUMAN	nuclear factor I/A isoform 1	398					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2						GACGCTGAAAGAATTTGTCCA	0.493													0	0	0	0.000602	0	5	48										C	61869892	G	C	61869892	3	2	128	1	0	0	0	0	1	0	0	0	10370	943	33	1	1368	1	NFIA	1	61869892	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	14791102	61869892	187380729	13	38052										
DNASE2B	58511	broad.mit.edu	37	chr1	84880418	84880418	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccaaaagggcaccaaaaatcGctggacatgtattggagacc	10	10	0	1	rs146223730		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:84880418G>A	uc001djt.1	+	6	986	c.953G>A	c.(952-954)CGC>CAC	p.R318H	DNASE2B_uc001dju.1_Missense_Mutation_p.R110H|DNASE2B_uc009wch.1_Missense_Mutation_p.R110H	NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta isoform 1 precursor	318					DNA metabolic process	lysosome	deoxyribonuclease II activity				0				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		ACCAAAAATCGCTGGACATGT	0.388								Direct_reversal_of_damage					0	0	0	0.008291	0	11	34										A	84880418	G	A	84880418	3	1	128	1	0	0	0	0	1	0	0	0	4665	1087	38	2	975	2	DNASE2B	1	84880418	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	23010526	84880418	164370203	14	38053										
SLC25A24	29957	broad.mit.edu	37	chr1	108679440	108679440	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggccaaccatattcagctgTggggaaccttctaacatggc	10	11	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:108679440T>C	uc001dvn.3	-	10	1483	c.1269A>G	c.(1267-1269)CCA>CCG	p.P423P	SLC25A24_uc001dvm.2_Silent_p.P404P	NM_013386	NP_037518	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 member 24 isoform 1	423	Mitochondrial matrix (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TATTCAGCTGTGGGGAACCTT	0.373													0	0	0	0.004482	0	9	36										C	108679440	T	C	108679440	2	2	128	1	0	0	0	0	0	0	0	1	14487	1683	59	5		5	SLC25A24	1	108679440	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	23799022	108679440	140571181	15	38054										
DDX20	11218	broad.mit.edu	37	chr1	112308496	112308496	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agaaaatagagagaacccttCaaattcagaaagctcatggt	8	7	3	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:112308496C>G	uc001ebs.2	+	11	1807	c.1450C>G	c.(1450-1452)CAA>GAA	p.Q484E	DDX20_uc010owf.1_Missense_Mutation_p.Q246E|DDX20_uc001ebt.2_Missense_Mutation_p.Q92E	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	484	SMN interacting.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGAACCCTTCAAATTCAGAA	0.368													0	0	0	0.006214	0	10	78										G	112308496	C	G	112308496	3	3	128	1	0	0	0	0	1	0	0	0	4348	827	29	1	1492	1	DDX20	1	112308496	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3629056	112308496	136942125	16	38055										
BCL9	607	broad.mit.edu	37	chr1	147090920	147090920	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agtgacccctgtctcccaggGgagcaatagctcttcagcag	11	13	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:147090920G>A	uc001epq.2	+	8	1699	c.959G>A	c.(958-960)GGG>GAG	p.G320E	BCL9_uc010ozr.1_Missense_Mutation_p.G246E	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	320	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GTCTCCCAGGGGAGCAATAGC	0.607			T	IGH@|IGL@	B-ALL								0	0	0	0.001984	0	7	93										A	147090920	G	A	147090920	3	1	128	1	0	0	0	0	1	0	0	0	1381	1232	43	2	977	2	BCL9	1	147090920	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	34782424	147090920	102159701	17	38056										
SELENBP1	8991	broad.mit.edu	37	chr1	151337485	151337485	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgcttcccatccaggctgagCtggatcatctgagggcctcc	11	15	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:151337485C>G	uc001exx.2	-	11	1220	c.1173G>C	c.(1171-1173)CAG>CAC	p.Q391H	SELENBP1_uc010pcy.1_Missense_Mutation_p.Q433H|SELENBP1_uc001exy.2_Missense_Mutation_p.Q288H|SELENBP1_uc001exz.2_Missense_Mutation_p.Q288H|SELENBP1_uc010pcz.1_Missense_Mutation_p.Q329H|SELENBP1_uc009wms.2_Missense_Mutation_p.Q227H|SELENBP1_uc009wmt.2_Missense_Mutation_p.Q288H|SELENBP1_uc001eya.2_Missense_Mutation_p.Q327H|SELENBP1_uc009wmu.2_Missense_Mutation_p.A260P	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	391					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCAGGCTGAGCTGGATCATCT	0.567													0	0	0	0.004672	0	3	7										G	151337485	C	G	151337485	3	3	128	1	0	0	0	0	1	0	0	0	14014	796	28	4	253	4	SELENBP1	1	151337485	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	4246565	151337485	97913136	18	38057										
THBS3	7059	broad.mit.edu	37	chr1	155170384	155170384	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttctgctggtctttgttgggGaacagccggcagttgtcctg	14	9	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:155170384G>T	uc001fix.2	-	14	1589	c.1566C>A	c.(1564-1566)TTC>TTA	p.F522L	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Missense_Mutation_p.F513L|THBS3_uc001fiz.2_Missense_Mutation_p.F485L|THBS3_uc001fiy.2_Missense_Mutation_p.F51L|THBS3_uc010pfu.1_Missense_Mutation_p.F402L|THBS3_uc010pfv.1_Intron|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	522	TSP type-3 2.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTTTGTTGGGGAACAGCCGGC	0.517													1	0	1.58986e-06	0.008291	1.76115e-06	10	76										T	155170384	G	T	155170384	3	4	128	1	0	0	0	0	1	0	0	0	15852	1165	41	3	1344	3	THBS3	1	155170384	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3832899	155170384	94080237	19	38058										
FCRL5	83416	broad.mit.edu	37	chr1	157514143	157514143	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tagaaccctgaatctttactCcacatggcagtaatctggaa	7	10	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:157514143C>G	uc001fqu.2	-	5	911	c.753G>C	c.(751-753)TGG>TGC	p.W251C	FCRL5_uc009wsm.2_Missense_Mutation_p.W251C|FCRL5_uc010phv.1_Missense_Mutation_p.W251C|FCRL5_uc010phw.1_Missense_Mutation_p.W166C|FCRL5_uc001fqv.1_Missense_Mutation_p.W251C|FCRL5_uc010phx.1_Missense_Mutation_p.W2C	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	251	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AATCTTTACTCCACATGGCAG	0.512													0	0	0	0.001855	0	13	171										G	157514143	C	G	157514143	3	3	128	1	0	0	0	0	1	0	0	0	5798	856	30	1	2232	1	FCRL5	1	157514143	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2343759	157514143	91736478	20	38059										
FCRL3	115352	broad.mit.edu	37	chr1	157667580	157667580	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgatcttctctaaattataaCtattaggaagctgttttcca	5	7	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:157667580C>G	uc001frb.2	-	5	720	c.428G>C	c.(427-429)AGT>ACT	p.S143T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.S143T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Missense_Mutation_p.S143T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	143	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TAAATTATAACTATTAGGAAG	0.348													0	0	0	0.003163	0	15	114										G	157667580	C	G	157667580	3	3	128	1	0	0	0	0	1	0	0	0	5796	565	20	4	1820	4	FCRL3	1	157667580	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	153437	157667580	91583041	21	38060										
KIRREL	55243	broad.mit.edu	37	chr1	158059372	158059372	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tacacctgccgggccatcgtGcctcgaatcggagtggctga	13	13	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:158059372G>T	uc001frn.3	+	9	1529	c.1125G>T	c.(1123-1125)GTG>GTT	p.V375V	KIRREL_uc010pib.1_Silent_p.V275V|KIRREL_uc009wsq.2_Silent_p.V211V|KIRREL_uc001fro.3_Silent_p.V189V	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	375	Extracellular (Potential).|Ig-like C2-type 4.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					GGGCCATCGTGCCTCGAATCG	0.637													1	0	1.56452e-12	0.007413	1.84522e-12	18	36										T	158059372	G	T	158059372	2	4	128	1	0	0	0	0	0	0	0	1	8324	1306	46	4		4	KIRREL	1	158059372	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	391792	158059372	91191249	22	38061										
CADM3	57863	broad.mit.edu	37	chr1	159166681	159166681	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgatttgtctgcctcgacagCccccagcagtacctatggga	10	13	1	1	rs149370954	by1000genomes	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:159166681C>G	uc001ftl.2	+	7	925	c.783C>G	c.(781-783)GTC>GTG	p.V261V	CADM3_uc009wsy.1_Silent_p.V215V|CADM3_uc001ftk.2_Silent_p.V295V|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	261	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					GCCTCGACAGCCCCCAGCAGT	0.517													0	0	0	0.000602	0	5	53										G	159166681	C	G	159166681	2	3	128	1	0	0	0	0	0	0	0	1	2568	753	26	4		4	CADM3	1	159166681	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1107309	159166681	90083940	23	38062										
SLAMF9	89886	broad.mit.edu	37	chr1	159923348	159923348	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gatgatgttctcaacctcttCatctggtggtatttccaggg	10	9	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:159923348C>T	uc001fus.2	-	2	259	c.142G>A	c.(142-144)GAA>AAA	p.E48K	SLAMF9_uc009wtd.2_Missense_Mutation_p.E48K|SLAMF9_uc001fut.2_Missense_Mutation_p.E48K	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	48	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCAACCTCTTCATCTGGTGGT	0.532													0	0	0	0.008291	0	9	83										T	159923348	C	T	159923348	3	4	128	1	0	0	0	0	1	0	0	0	14371	835	29	1	739	1	SLAMF9	1	159923348	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	756667	159923348	89327273	24	38063										
PEX19	5824	broad.mit.edu	37	chr1	160253381	160253381	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	catcaggggccgtggtggtaGaagggggtgctggggagggt	23	5	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:160253381G>A	uc001fvs.2	-	2	146	c.119C>T	c.(118-120)TCT>TTT	p.S40F	DCAF8_uc010pjc.1_Intron|PEX19_uc010pje.1_RNA|PEX19_uc001fvt.2_Intron	NM_002857	NP_002848	P40855	PEX19_HUMAN	peroxisomal biogenesis factor 19 isoform a	40	Necessary for PEX19 function on peroxisome biogenesis.|Docking to the peroxisome membrane and binding to PEX3.				peroxisome membrane biogenesis|peroxisome organization|protein targeting to peroxisome|transmembrane transport	brush border membrane|cytosol|integral to membrane|nucleus|peroxisomal membrane	protein binding|protein N-terminus binding				0	all_cancers(52;1.27e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CGTGGTGGTAGAAGGGGGTGC	0.547													0	0	0	0.013537	0	11	40										A	160253381	G	A	160253381	3	1	128	1	0	0	0	0	1	0	0	0	11744	942	33	1	808	1	PEX19	1	160253381	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	330033	160253381	88997240	25	38064										
VANGL2	57216	broad.mit.edu	37	chr1	160395046	160395046	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcatcgttttcctcttaaaaCgccaggacttcagcctggtg	9	12	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:160395046C>T	uc001fwb.1	+	9	1743	c.1444C>T	c.(1444-1446)CGC>TGC	p.R482C	VANGL2_uc001fwc.1_Missense_Mutation_p.R482C	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	482	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTCTTAAAACGCCAGGACTT	0.532													0	0	0	0.009096	0	4	59										T	160395046	C	T	160395046	3	4	128	1	0	0	0	0	1	0	0	0	17117	536	19	2	1470	2	VANGL2	1	160395046	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	141665	160395046	88855575	26	38065										
LY9	4063	broad.mit.edu	37	chr1	160769632	160769632	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tccccctaaacatctcagtaGacacagagattgagaacgtc	7	12	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:160769632G>A	uc001fwu.2	+	2	264	c.214G>A	c.(214-216)GAC>AAC	p.D72N	LY9_uc001fwt.2_Missense_Mutation_p.D72N|LY9_uc010pjs.1_Missense_Mutation_p.D72N|LY9_uc001fwv.2_Missense_Mutation_p.D72N|LY9_uc001fww.2_Missense_Mutation_p.D72N|LY9_uc001fwx.2_Missense_Mutation_p.D72N|LY9_uc001fwy.1_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	72	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CATCTCAGTAGACACAGAGAT	0.493													0	0	0	0.006214	0	10	77										A	160769632	G	A	160769632	3	1	128	1	0	0	0	0	1	0	0	0	9101	942	33	1	220	1	LY9	1	160769632	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	374586	160769632	88480989	27	38066										
ATF6	22926	broad.mit.edu	37	chr1	161928235	161928235	+	Splice_Site	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgtgtatattcctgtctgcaGagaatgtgatcaatgggcag	12	6	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:161928235G>A	uc001gbr.2	+	16	1872	c.1805_splice	c.e16-1	p.E602_splice	ATF6_uc001gbs.2_5'Flank	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6						positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			CCTGTCTGCAGAGAATGTGAT	0.433													0	0	0	0.001984	0	7	90										A	161928235	G	A	161928235	5	1	128	1	0	0	0	0	0	0	1	0	1084	956	33	1	1866	1	ATF6	1	161928235	Splice_Site	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1158603	161928235	87322386	28	38067										
FMO3	2328	broad.mit.edu	37	chr1	171073096	171073096	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gccaaagaaaagaacctcctGaagtacatacaatttaaggt	7	8	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:171073096G>A	uc001ghi.2	+	3	414	c.303G>A	c.(301-303)CTG>CTA	p.L101L	FMO3_uc001ghh.2_Silent_p.L101L|FMO3_uc010pmb.1_Silent_p.L81L|FMO3_uc010pmc.1_Intron|MIR1295_hsa-mir-1295|MI0006357_5'Flank	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	101					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGAACCTCCTGAAGTACATAC	0.378													0	0	0	0.010729	0	12	55										A	171073096	G	A	171073096	2	1	128	1	0	0	0	0	0	0	0	1	5956	1277	45	1		1	FMO3	1	171073096	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9144861	171073096	78177525	29	38068										
TNN	63923	broad.mit.edu	37	chr1	175052985	175052985	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgaggtggactactacaagcTgcgatatggccccatgacag	12	10	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:175052985T>A	uc001gkl.1	+	5	1261	c.1148T>A	c.(1147-1149)CTG>CAG	p.L383Q	TNN_uc010pmx.1_Missense_Mutation_p.L383Q	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	383	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TACTACAAGCTGCGATATGGC	0.552													0	0	0	0.001168	0	6	80										A	175052985	T	A	175052985	3	1	128	1	0	0	0	0	1	0	0	0	16320	1580	55	5	1162	5	TNN	1	175052985	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	3979889	175052985	74197636	30	38069										
ASTN1	460	broad.mit.edu	37	chr1	177133537	177133537	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccccgggactcacccagcacGaagtagggcagctccgtgtt	12	15	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:177133537G>A	uc001glc.2	-	1	488	c.276C>T	c.(274-276)TTC>TTT	p.F92F	ASTN1_uc001glb.1_Silent_p.F92F|ASTN1_uc001gld.1_Silent_p.F92F|ASTN1_uc009wwx.1_Silent_p.F92F	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	92					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CACCCAGCACGAAGTAGGGCA	0.692													0	0	0	0.009096	0	4	15										A	177133537	G	A	177133537	2	1	128	1	0	0	0	0	0	0	0	1	1064	1049	37	1		1	ASTN1	1	177133537	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2080552	177133537	72117084	31	38070										
CACNA1E	777	broad.mit.edu	37	chr1	181754895	181754895	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggagccttcatctctgcctcAggagatcattgctaatgcca	9	12	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:181754895A>T	uc001gow.2	+	43	5891	c.5726A>T	c.(5725-5727)CAG>CTG	p.Q1909L	CACNA1E_uc009wxs.2_Missense_Mutation_p.Q1797L|CACNA1E_uc009wxt.2_Missense_Mutation_p.Q1135L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1909	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCTCTGCCTCAGGAGATCATT	0.507													0	0	0	0.008871	0	20	248										T	181754895	A	T	181754895	3	4	128	1	0	0	0	0	1	0	0	0	2542	188	7	5	5896	5	CACNA1E	1	181754895	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	4621358	181754895	67495726	32	38071										
C1orf25	81627	broad.mit.edu	37	chr1	185113039	185113039	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tattttcaatttatcttaccGatttagtttcattttggggt	6	5	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:185113039G>C	uc001grf.3	-	6	1050	c.778C>G	c.(778-780)CGG>GGG	p.R260G	C1orf25_uc010pon.1_Missense_Mutation_p.R104G	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	260						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						TTATCTTACCGATTTAGTTTC	0.303													0	0	0	0.00308	0	8	34										C	185113039	G	C	185113039	3	2	128	1	0	0	0	0	1	0	0	0	2034	1072	37	1	1463	1	C1orf25	1	185113039	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3358144	185113039	64137582	33	38072										
HMCN1	83872	broad.mit.edu	37	chr1	186045614	186045614	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaacatgctagatactggcaGgaatggtgaagccaaagatg	12	6	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:186045614G>T	uc001grq.1	+	54	8574	c.8345G>T	c.(8344-8346)AGG>ATG	p.R2782M		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2782	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATACTGGCAGGAATGGTGAA	0.413													1	0	1.23904e-05	0.000602	1.34649e-05	5	85										T	186045614	G	T	186045614	3	4	128	1	0	0	0	0	1	0	0	0	7220	1000	35	4	8559	4	HMCN1	1	186045614	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	932575	186045614	63205007	34	38073										
CHIT1	1118	broad.mit.edu	37	chr1	203188877	203188877	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gggcccccactctggtgtctGatgaggaggccagtgtgaag	16	10	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:203188877G>T	uc001gzn.2	-	8	926	c.830C>A	c.(829-831)TCA>TAA	p.S277*	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_Nonsense_Mutation_p.S68*|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Nonsense_Mutation_p.S268*	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	277					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TCTGGTGTCTGATGAGGAGGC	0.597													1	0	0.000673444	0.008291	0.00070694	11	54										T	203188877	G	T	203188877	4	4	128	1	0	0	0	0	0	1	0	0	3346	1294	45	3	586	3	CHIT1	1	203188877	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	17143263	203188877	46061744	35	38074										
CNTN2	6900	broad.mit.edu	37	chr1	205027351	205027351	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgaagctggagccaggttcCcgtcaccagctggtgggggg	17	10	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:205027351C>T	uc001hbr.2	+	4	527	c.258C>T	c.(256-258)TCC>TCT	p.S86S	CNTN2_uc001hbq.1_5'UTR|CNTN2_uc009xbi.2_5'UTR|CNTN2_uc001hbs.2_5'Flank	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	86	Ig-like C2-type 1.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCCAGGTTCCCGTCACCAGC	0.632													0	0	0	0.009096	0	4	25										T	205027351	C	T	205027351	2	4	128	1	0	0	0	0	0	0	0	1	3641	610	22	2		2	CNTN2	1	205027351	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1838474	205027351	44223270	36	38075										
NUAK2	81788	broad.mit.edu	37	chr1	205290642	205290642	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtggtggtgccgcttcaccgCctgcttcttcattaggggct	13	12	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:205290642C>A	uc001hce.2	-	1	242	c.115G>T	c.(115-117)GCG>TCG	p.A39S		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	39					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CGCTTCACCGCCTGCTTCTTC	0.667													1	0	0.00909568	0.009096	0.00935222	4	19										A	205290642	C	A	205290642	3	1	128	1	0	0	0	0	1	0	0	0	10713	739	26	4	1799	4	NUAK2	1	205290642	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	263291	205290642	43959979	37	38076										
PIGR	5284	broad.mit.edu	37	chr1	207110743	207110743	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggtcactgagcccctcaggtCttcataaaccagctcgggct	10	14	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:207110743C>G	uc001hez.2	-	4	926	c.742G>C	c.(742-744)GAC>CAC	p.D248H	PIGR_uc009xbz.2_Missense_Mutation_p.D248H	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	248	Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CCCCTCAGGTCTTCATAAACC	0.547													0	0	0	0.010729	0	12	68										G	207110743	C	G	207110743	3	3	128	1	0	0	0	0	1	0	0	0	11897	913	32	1	1584	1	PIGR	1	207110743	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1820101	207110743	42139878	38	38077										
C1orf116	79098	broad.mit.edu	37	chr1	207200869	207200869	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgggtggaggtgctgctcatCatgctgtcacagctgccgac	14	12	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:207200869C>A	uc001hfd.2	-	2	334	c.75G>T	c.(73-75)ATG>ATT	p.M25I	C1orf116_uc009xcb.1_Intron	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	25						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					TGCTGCTCATCATGCTGTCAC	0.542													1	0	3.59834e-05	0.001168	3.88931e-05	6	51										A	207200869	C	A	207200869	3	1	128	1	0	0	0	0	1	0	0	0	1989	826	29	3	1742	3	C1orf116	1	207200869	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	90126	207200869	42049752	39	38078										
IRF6	3664	broad.mit.edu	37	chr1	209974736	209974736	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccagccagggctttagccggActctgcgggggtggagggcc	18	12	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:209974736A>T	uc001hhq.1	-	3	286	c.23T>A	c.(22-24)GTC>GAC	p.V8D	IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Missense_Mutation_p.V8D	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	8	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CTTTAGCCGGACTCTGCGGGG	0.597										HNSCC(57;0.16)			0	0	0	0.003163	0	16	56										T	209974736	A	T	209974736	3	4	128	1	0	0	0	0	1	0	0	0	7834	275	10	5	1408	5	IRF6	1	209974736	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	2773867	209974736	39275885	40	38079										
PROX1	5629	broad.mit.edu	37	chr1	214185050	214185050	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcactacaataaagcaaatGactttgaggtaggaactaat	8	6	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:214185050G>A	uc001hkh.2	+	4	2292	c.2020G>A	c.(2020-2022)GAC>AAC	p.D674N		NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	674	Prospero-like.				aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TAAAGCAAATGACTTTGAGGT	0.368													0	0	0	0.010771	0	46	60										A	214185050	G	A	214185050	3	1	128	1	0	0	0	0	1	0	0	0	12560	1290	45	1	2030	1	PROX1	1	214185050	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4210314	214185050	35065571	41	38080										
TP53BP2	7159	broad.mit.edu	37	chr1	223994610	223994610	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctggcgagatgccatttcctGaagttcagcaagagtcagat	11	9	2	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:223994610G>A	uc010pvb.1	-	5	704	c.412C>T	c.(412-414)CAG>TAG	p.Q138*	TP53BP2_uc001hod.2_Nonsense_Mutation_p.Q9*	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	132	Gln-rich.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCCATTTCCTGAAGTTCAGCA	0.368													0	0	0	0.003755	0	36	76										A	223994610	G	A	223994610	4	1	128	1	0	0	0	0	0	1	0	0	16381	1299	45	1	3048	1	TP53BP2	1	223994610	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9809560	223994610	25256011	42	38081										
WDR26	80232	broad.mit.edu	37	chr1	224599169	224599169	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	taactgttgtatcttttgatCctgttgctagtttagtgcca	8	7	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:224599169C>G	uc001hop.3	-	7	1043	c.677G>C	c.(676-678)GGA>GCA	p.G226A	WDR26_uc001hoq.3_Missense_Mutation_p.G210A|WDR26_uc010pvh.1_5'UTR	NM_025160	NP_079436	Q9H7D7	WDR26_HUMAN	WD repeat domain 26 isoform a	373	WD 1.					cytoplasm|nucleus					0				GBM - Glioblastoma multiforme(131;0.0104)		ATCTTTTGATCCTGTTGCTAG	0.368													0	0	0	0.000602	0	5	68										G	224599169	C	G	224599169	3	3	128	1	0	0	0	0	1	0	0	0	17280	855	30	1	899	1	WDR26	1	224599169	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	604559	224599169	24651452	43	38082										
PCNXL2	80003	broad.mit.edu	37	chr1	233120095	233120095	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcgaggccgtgtcgtccagGcccatgtcctcctggcttgc	13	15	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:233120095G>T	uc001hvl.2	-	34	6604	c.6369C>A	c.(6367-6369)GGC>GGA	p.G2123G	PCNXL2_uc001hvk.1_3'UTR|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	2123						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TGTCGTCCAGGCCCATGTCCT	0.667													1	0	0.00024832	0.009096	0.000263429	4	25										T	233120095	G	T	233120095	2	4	128	1	0	0	0	0	0	0	0	1	11592	1190	42	4		4	PCNXL2	1	233120095	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	8520926	233120095	16130526	44	38083										
FH	2271	broad.mit.edu	37	chr1	241665791	241665791	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaatgtccattgctgcctccGacagtgacagcaacatggtt	9	11	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:241665791G>T	uc001hyx.2	-	8	1220	c.1188C>A	c.(1186-1188)GTC>GTA	p.V396V		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	396					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		TGCTGCCTCCGACAGTGACAG	0.413			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				1	0	2.32078e-09	0.003163	2.67424e-09	15	60										T	241665791	G	T	241665791	2	4	128	1	0	0	0	0	0	0	0	1	5875	1045	37	3		3	FH	1	241665791	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	8545696	241665791	7584830	45	38084										
CHML	1122	broad.mit.edu	37	chr1	241798263	241798263	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cttgttctacctttccttccCgaaatgcaagaatcctagtg	6	12	1	1	rs148967774		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr1:241798263C>T	uc001hzd.2	-	1	970	c.806G>A	c.(805-807)CGG>CAG	p.R269Q	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	269					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity	p.R269R(1)		ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTTTCCTTCCCGAAATGCAAG	0.353													0	0	0	0.00245	0	15	68										T	241798263	C	T	241798263	3	4	128	1	0	0	0	0	1	0	0	0	3351	652	23	2	1168	2	CHML	1	241798263	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	132472	241798263	7452358	46	38085										
ASAP2	8853	broad.mit.edu	37	chr2	9475228	9475228	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtgtgtttttaaagatcaaaCaggcccaggatgaagaaaga	11	5	1	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:9475228C>G	uc002qzh.2	+	9	1109	c.769C>G	c.(769-771)CAG>GAG	p.Q257E	ASAP2_uc002qzi.2_Missense_Mutation_p.Q257E	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	257	Potential.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						AAAGATCAAACAGGCCCAGGA	0.413													0	0	0	0.008291	0	9	40										G	9475228	C	G	9475228	3	3	128	1	0	0	0	0	1	0	0	0	1011	479	17	4	803	4	ASAP2	2	9475228	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		9475228	233724145	47	38086										
OTOF	9381	broad.mit.edu	37	chr2	26702466	26702466	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcctcatcccccggctccttCcggggccgaggccgctgggg	14	18	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:26702466C>T	uc002rhk.2	-	17	2095	c.1968G>A	c.(1966-1968)CGG>CGA	p.R656R	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	656	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGGCTCCTTCCGGGGCCGAG	0.627													0	0	0	0.006214	0	8	21										T	26702466	C	T	26702466	2	4	128	1	0	0	0	0	0	0	0	1	11303	842	30	1		1	OTOF	2	26702466	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	17227238	26702466	216496907	48	38087										
ABHD1	84696	broad.mit.edu	37	chr2	27351315	27351315	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgtgtgattacagaggcctCggctggtggctgggccgcag	17	10	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:27351315C>A	uc002rit.2	+	2	281	c.121C>A	c.(121-123)CGG>AGG	p.R41R	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_Intron	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	41						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGAGGCCTCGGCTGGTGGC	0.602													1	0	3.27435e-08	0.00245	3.71959e-08	14	50										A	27351315	C	A	27351315	2	1	128	1	0	0	0	0	0	0	0	1	73	875	31	3		3	ABHD1	2	27351315	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	648849	27351315	215848058	49	38088										
XDH	7498	broad.mit.edu	37	chr2	31560610	31560610	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tattacctgtgtgctgagctCgagctgcacggatggcatct	12	10	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:31560610C>G	uc002rnv.1	-	35	3927	c.3848G>C	c.(3847-3849)CGA>CCA	p.R1283P		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1283					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GTGCTGAGCTCGAGCTGCACG	0.577													0	0	0	0.003163	0	16	36										G	31560610	C	G	31560610	3	3	128	1	0	0	0	0	1	0	0	0	17423	884	31	1	161	1	XDH	2	31560610	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	4209295	31560610	211638763	50	38089										
BIRC6	57448	broad.mit.edu	37	chr2	32740790	32740790	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgcaactgttgcgttctttCtacagtgcatttcatgccat	7	10	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:32740790C>G	uc010ezu.2	+	55	11436	c.11302C>G	c.(11302-11304)CTA>GTA	p.L3768V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3768					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGCGTTCTTTCTACAGTGCAT	0.393													0	0	0	0.003163	0	16	35										G	32740790	C	G	32740790	3	3	128	1	0	0	0	0	1	0	0	0	1438	912	32	1	11520	1	BIRC6	2	32740790	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1180180	32740790	210458583	51	38090										
ABCG5	64240	broad.mit.edu	37	chr2	44051155	44051155	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccctttagcacattgcttcgGacccgcagaacgaagaaaag	9	12	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:44051155G>C	uc002rtn.2	-	9	1361	c.1221C>G	c.(1219-1221)GTC>GTG	p.V407V	ABCG5_uc002rtm.2_Silent_p.V12V|ABCG5_uc002rto.2_Silent_p.V236V|ABCG5_uc002rtp.2_Silent_p.V12V	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	407	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CATTGCTTCGGACCCGCAGAA	0.512													0	0	0	0.00499	0	17	51										C	44051155	G	C	44051155	2	2	128	1	0	0	0	0	0	0	0	1	71	1161	41	1		1	ABCG5	2	44051155	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	11310365	44051155	199148218	52	38091										
CCDC85A	114800	broad.mit.edu	37	chr2	56603022	56603022	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tctgcagctagcttcagtggAcatgccacaccttcccagca	8	15	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:56603022A>G	uc002rzn.2	+	5	2026	c.1524A>G	c.(1522-1524)GGA>GGG	p.G508G		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	508										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GCTTCAGTGGACATGCCACAC	0.458													0	0	0	0.001168	0	6	27										G	56603022	A	G	56603022	2	3	128	1	0	0	0	0	0	0	0	1	2859	262	10	5		5	CCDC85A	2	56603022	Silent	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	12551867	56603022	186596351	53	38092										
CEP68	23177	broad.mit.edu	37	chr2	65299062	65299073	+	In_Frame_Del	DEL	CTGCCAGATTCC	CTGCCAGATTCC	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgagtactgggcctgtgtgCtgccagattccctgcctcca							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:65299062_65299073delCTGCCAGATTCC	uc002sdl.3	+	3	1046_1057	c.832_843delCTGCCAGATTCC	c.(832-843)CTGCCAGATTCCdel	p.LPDS278del	CEP68_uc002sdj.2_In_Frame_Del_p.LPDS278del|CEP68_uc010yqb.1_In_Frame_Del_p.LPDS278del|CEP68_uc002sdk.3_In_Frame_Del_p.LPDS278del|CEP68_uc010yqc.1_In_Frame_Del_p.LPDS278del|CEP68_uc010yqd.1_In_Frame_Del_p.LPDS278del	NM_015147	NP_055962	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	278_281					centrosome organization	centrosome				skin(1)	1						GGCCTGTGTGCTGCCAGATTCCCTGCCTCCAT	0.594																		8	134	---	---								-	65299073	CTGCCAGATTCC	-	65299062	7	5	128	1	0	1	0	1	0	0	0	0	3258	796	28	0	838	0	CEP68	2	65299062	In_Frame_Del	DEL	CTGCCAGATTCC	TCGA-K4-A3WS-01A-11D-A22Z-08	8696040	65299062	177900311	54	38093										
CD207	50489	broad.mit.edu	37	chr2	71058238	71058238	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaaagaaacgttttgtcacaTggggcatcattccaggcctg	10	9	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:71058238T>C	uc002shg.2	-	6	977	c.930A>G	c.(928-930)CCA>CCG	p.P310P		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	310	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						TTTTGTCACATGGGGCATCAT	0.493													0	0	0	0.001984	0	6	38										C	71058238	T	C	71058238	2	2	128	1	0	0	0	0	0	0	0	1	2983	1451	51	5		5	CD207	2	71058238	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	5759176	71058238	172141135	55	38094										
NAT8	9027	broad.mit.edu	37	chr2	73868318	73868337	+	Frame_Shift_Del	DEL	ACTGTCCACAAAGAGATGAA	ACTGTCCACAAAGAGATGAA	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atcccctgacgacggtgctcActgtccacaaagagatgaaa					rs13538	byFrequency	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:73868318_73868337delACTGTCCACAAAGAGATGAA	uc002sji.1	-	2	586_605	c.419_438delTTCATCTCTTTGTGGACAGT	c.(418-438)TTTCATCTCTTTGTGGACAGTfs	p.F140fs		NM_003960	NP_003951	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8	140_146	N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			ovary(1)	1						GACGGTGCTCACTGTCCACAAAGAGATGAAACAGCTGCAA	0.568																		8	76	---	---								-	73868337	ACTGTCCACAAAGAGATGAA	-	73868318	7	5	128	1	0	1	0	1	0	0	0	0	10179	156	6	0	249	0	NAT8	2	73868318	Frame_Shift_Del	DEL	ACTGTCCACAAAGAGATGAA	TCGA-K4-A3WS-01A-11D-A22Z-08	2810080	73868318	169331055	56	38095										
GCC2	9648	broad.mit.edu	37	chr2	109086923	109086924	+	Frame_Shift_Ins	INS	-	-	G													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggatgagttttttcatgaacINSgggaagacttagagtttaaa							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:109086923_109086924insG	uc002tec.2	+	6	1292_1293	c.1138_1139insG	c.(1138-1140)CGGfs	p.R380fs	GCC2_uc002ted.2_Frame_Shift_Ins_p.R279fs	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	380	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						TTTTCATGAACGGGAAGACTTA	0.282																		35	78	---	---								G	109086924	-	G	109086923	7	5	128	1	0	1	1	0	0	0	0	0	6286	527	19	0	1160	0	GCC2	2	109086923	Frame_Shift_Ins	INS	-	TCGA-K4-A3WS-01A-11D-A22Z-08	35218605	109086923	134112450	57	38096										
NPHP1	4867	broad.mit.edu	37	chr2	110881615	110881615	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	catggtaaaccaggagaaacGtggacttcaggaactctttg	11	8	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:110881615G>C	uc002tfn.3	-	20	2046	c.1952C>G	c.(1951-1953)ACG>AGG	p.T651R	NPHP1_uc002tfm.3_Missense_Mutation_p.T596R|NPHP1_uc002tfl.3_Missense_Mutation_p.T652R|NPHP1_uc002tfo.3_Missense_Mutation_p.T533R|NPHP1_uc010ywx.1_Missense_Mutation_p.T595R	NM_207181	NP_997064	O15259	NPHP1_HUMAN	nephrocystin 1 isoform 2	651					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2						CAGGAGAAACGTGGACTTCAG	0.458													0	0	0	0.001984	0	7	85										C	110881615	G	C	110881615	3	2	128	1	0	0	0	0	1	0	0	0	10579	1145	40	4	250	4	NPHP1	2	110881615	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1794692	110881615	132317758	58	38097										
FBLN7	129804	broad.mit.edu	37	chr2	112944892	112944892	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcctgcggtttgggatcgtgGgtgggaacagccgcggccac	18	11	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:112944892G>T	uc002tho.1	+	8	1400	c.1129G>T	c.(1129-1131)GGT>TGT	p.G377C	FBLN7_uc002thn.2_Intron|FBLN7_uc010fki.1_Missense_Mutation_p.G331C|FBLN7_uc010fkj.1_Missense_Mutation_p.G243C	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	377					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						TGGGATCGTGGGTGGGAACAG	0.642													1	0	3.86212e-05	0.008291	4.1632e-05	10	115										T	112944892	G	T	112944892	3	4	128	1	0	0	0	0	1	0	0	0	5701	1232	43	4	1159	4	FBLN7	2	112944892	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2063277	112944892	130254481	59	38098										
RAB3GAP1	22930	broad.mit.edu	37	chr2	135884205	135884205	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgttagagttcgaaaagctGagaatcctcagtgtttgcta	10	7	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:135884205G>A	uc002tuj.2	+	11	977	c.952G>A	c.(952-954)GAG>AAG	p.E318K	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.E318K|RAB3GAP1_uc010fng.2_Missense_Mutation_p.E143K|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	318						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TCGAAAAGCTGAGAATCCTCA	0.368													0	0	0	0.012213	0	33	80										A	135884205	G	A	135884205	3	1	128	1	0	0	0	0	1	0	0	0	12935	1291	45	1	994	1	RAB3GAP1	2	135884205	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	22939313	135884205	107315168	60	38099										
THSD7B	80731	broad.mit.edu	37	chr2	138414501	138414501	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtcttttgagaaccaagacaGctgcccccaacaggttctag	9	12	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:138414501G>T	uc002tva.1	+	22	4154	c.4154G>T	c.(4153-4155)AGC>ATC	p.S1385I	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AACCAAGACAGCTGCCCCCAA	0.433													1	0	3.83957e-06	0.00278	4.22986e-06	21	91										T	138414501	G	T	138414501	3	4	128	1	0	0	0	0	1	0	0	0	15877	971	34	4	4239	4	THSD7B	2	138414501	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2530296	138414501	104784872	61	38100										
SCN1A	6323	broad.mit.edu	37	chr2	166896082	166896082	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aataattttcagaaacatttCtgctgtaaagatcccagtga	6	7	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:166896082C>T	uc010zcz.1	-	14	2425	c.2407G>A	c.(2407-2409)GAA>AAA	p.E803K	SCN1A_uc002udo.3_Missense_Mutation_p.E683K|SCN1A_uc010fpk.2_Missense_Mutation_p.E655K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	814	Helical; Name=S2 of repeat II; (By similarity).|II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGAAACATTTCTGCTGTAAAG	0.333													0	0	0	0.001168	0	5	19										T	166896082	C	T	166896082	3	4	128	1	0	0	0	0	1	0	0	0	13914	922	32	1	3641	1	SCN1A	2	166896082	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	28481581	166896082	76303291	62	38101										
NFE2L2	4780	broad.mit.edu	37	chr2	178095532	178095532	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tctagtttttcttaacatctGgcttcttacttttgggaaca	6	8	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:178095532G>C	uc002ulh.3	-	5	2354	c.1799C>G	c.(1798-1800)CCA>CGA	p.P600R	NFE2L2_uc002ulg.3_Missense_Mutation_p.P584R|NFE2L2_uc010zfa.1_Missense_Mutation_p.P577R|NFE2L2_uc002uli.3_Missense_Mutation_p.P584R	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	600					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			CTTAACATCTGGCTTCTTACT	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.006214	0	10	97										C	178095532	G	C	178095532	3	2	128	1	0	0	0	0	1	0	0	0	10368	1348	47	4	22	4	NFE2L2	2	178095532	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	11199450	178095532	65103841	63	38102										
DFNB59	494513	broad.mit.edu	37	chr2	179323266	179323266	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atggatgaacagaatcccaaGggaagggacaaagctattgt	12	6	0	2	rs138967124	by1000genomes	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:179323266G>A	uc002umi.3	+	5	935	c.579G>A	c.(577-579)AAG>AAA	p.K193K	DFNB59_uc002umj.3_Silent_p.K193K	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	193					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			AGAATCCCAAGGGAAGGGACA	0.353													0	0	0	0.004482	0	9	81										A	179323266	G	A	179323266	2	1	128	1	0	0	0	0	0	0	0	1	4456	991	35	2		2	DFNB59	2	179323266	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1227734	179323266	63876107	64	38103										
TTN	7273	broad.mit.edu	37	chr2	179413895	179413895	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgtgggaggacctggtgggtTgacgggctctctacatttaa	15	7	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:179413895T>A	uc010zfg.1	-	288	84978	c.84754A>T	c.(84754-84756)AAC>TAC	p.N28252Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N21947Y|TTN_uc010zfi.1_Missense_Mutation_p.N21880Y|TTN_uc010zfj.1_Missense_Mutation_p.N21755Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29179							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTGGTGGGTTGACGGGCTCT	0.463													0	0	0	0.001168	0	5	44										A	179413895	T	A	179413895	3	1	128	1	0	0	0	0	1	0	0	0	16732	1812	63	5	15617	5	TTN	2	179413895	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	90629	179413895	63785478	65	38104										
TTN	7273	broad.mit.edu	37	chr2	179613062	179613062	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcatcaatactacttttctCcaccatagttctatttgaaa	2	10	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:179613062C>T	uc002unb.2	-	46	14289	c.14065G>A	c.(14065-14067)GAG>AAG	p.E4689K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTACTTTTCTCCACCATAGTT	0.318													0	0	0	0.013114	0	47	63										T	179613062	C	T	179613062	3	4	128	1	0	0	0	0	1	0	0	0	16732	864	30	1	96232	1	TTN	2	179613062	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	199167	179613062	63586311	66	38105										
TTN	7273	broad.mit.edu	37	chr2	179616411	179616411	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctataacttccagaatctctGtcttggacccttttaatctc	4	12	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:179616411G>T	uc002unb.2	-	46	10940	c.10716C>A	c.(10714-10716)GAC>GAA	p.D3572E	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAATCTCTGTCTTGGACCC	0.403													1	0	6.94344e-10	0.006122	8.04717e-10	19	104										T	179616411	G	T	179616411	3	4	128	1	0	0	0	0	1	0	0	0	16732	1368	48	4	99581	4	TTN	2	179616411	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3349	179616411	63582962	67	38106										
C2orf47	79568	broad.mit.edu	37	chr2	200820940	200820940	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctatttcgacaaagagttcaGcatcacagagttctccgagg	9	10	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:200820940G>A	uc002uvm.2	+	2	741	c.419G>A	c.(418-420)AGC>AAC	p.S140N	C2orf60_uc002uvj.3_5'Flank|C2orf60_uc002uvi.3_5'Flank|C2orf60_uc002uvk.3_5'Flank|C2orf60_uc010fss.2_5'Flank|C2orf60_uc002uvl.2_5'Flank	NM_024520	NP_078796	Q8WWC4	CB047_HUMAN	hypothetical protein LOC79568 precursor	140						mitochondrion					0						AAAGAGTTCAGCATCACAGAG	0.448													0	0	0	0.00632	0	27	84										A	200820940	G	A	200820940	3	1	128	1	0	0	0	0	1	0	0	0	2169	971	34	2	421	2	C2orf47	2	200820940	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	21204529	200820940	42378433	68	38107										
TRAF3IP1	26146	broad.mit.edu	37	chr2	239234477	239234477	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgcaaaaattagcttcctaCaaaaggccatagacgtggtt	8	8	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr2:239234477C>T	uc002vye.2	+	3	339	c.220C>T	c.(220-222)CAA>TAA	p.Q74*	TRAF3IP1_uc002vyf.2_Nonsense_Mutation_p.Q74*	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	74	Abolishes microtubules-binding when missing.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		TAGCTTCCTACAAAAGGCCAT	0.423													0	0	0	0.001855	0	12	53										T	239234477	C	T	239234477	4	4	128	1	0	0	0	0	0	1	0	0	16437	479	17	2	230	2	TRAF3IP1	2	239234477	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	38413537	239234477	3964896	69	38108										
ARPC4	10093	broad.mit.edu	37	chr3	9845628	9845628	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcatggaggagattgacaaGgagatcagtgagatgaagct	14	4	2	5			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:9845628G>C	uc003bsz.1	+	5	1011	c.432G>C	c.(430-432)AAG>AAC	p.K144N	ARPC4_uc003bta.1_Missense_Mutation_p.K54N|ARPC4_uc003btb.1_Missense_Mutation_p.K54N|ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Intron	NM_005718	NP_005709	P59998	ARPC4_HUMAN	actin related protein 2/3 complex subunit 4	144					actin filament polymerization|actin nucleation	Arp2/3 protein complex|cell projection|cytoplasm	actin binding				0	Medulloblastoma(99;0.227)					AGATTGACAAGGAGATCAGTG	0.468													0	0	0	0.001855	0	14	122										C	9845628	G	C	9845628	3	2	128	1	0	0	0	0	1	0	0	0	973	991	35	4	450	4	ARPC4	3	9845628	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		9845628	188176802	70	38109										
ATP2B2	491	broad.mit.edu	37	chr3	10419989	10419989	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcttgccctgcagcacggacTtctccttcttgtgcatgctg	10	14	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:10419989T>C	uc003bvt.2	-	10	1587	c.1148A>G	c.(1147-1149)AAG>AGG	p.K383R	ATP2B2_uc003bvv.2_Missense_Mutation_p.K338R|ATP2B2_uc003bvw.2_Missense_Mutation_p.K338R|ATP2B2_uc010hdo.2_Missense_Mutation_p.K88R	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	383	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CAGCACGGACTTCTCCTTCTT	0.607													0	0	0	0.00308	0	8	66										C	10419989	T	C	10419989	3	2	128	1	0	0	0	0	1	0	0	0	1140	1609	56	5	2639	5	ATP2B2	3	10419989	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	574361	10419989	187602441	71	38110										
SLC6A11	6538	broad.mit.edu	37	chr3	10858095	10858095	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agcgcgacaaggcggtccacGagcgcggccactggaacaac	14	14	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:10858095G>A	uc003bvz.2	+	1	179	c.145G>A	c.(145-147)GAG>AAG	p.E49K	SLC6A11_uc003bvy.1_Missense_Mutation_p.E49K	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	49	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GGCGGTCCACGAGCGCGGCCA	0.557													0	0	0	0.004672	0	3	13										A	10858095	G	A	10858095	3	1	128	1	0	0	0	0	1	0	0	0	14674	1059	37	1	147	1	SLC6A11	3	10858095	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	438106	10858095	187164335	72	38111										
ZNF502	91392	broad.mit.edu	37	chr3	44763523	44763523	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gagaatacatacaggggagaGaccctacaaatgcagtgaat	11	7	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:44763523G>A	uc011baa.1	+	4	1469	c.1214G>A	c.(1213-1215)AGA>AAA	p.R405K	ZNF502_uc003cns.2_Missense_Mutation_p.R405K|ZNF502_uc011bab.1_Missense_Mutation_p.R405K|ZNF502_uc003cnt.2_Missense_Mutation_p.R405K	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		ACAGGGGAGAGACCCTACAAA	0.413													0	0	0	0.003163	0	16	30										A	44763523	G	A	44763523	3	1	128	1	0	0	0	0	1	0	0	0	17947	942	33	1	1220	1	ZNF502	3	44763523	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	33905428	44763523	153258907	73	38112										
SLC6A20	54716	broad.mit.edu	37	chr3	45812892	45812892	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgccgaagcccaggccaagtGagaagaagatctgggtggct	15	9	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:45812892G>C	uc011bai.1	-	6	876	c.752C>G	c.(751-753)TCA>TGA	p.S251*	SLC6A20_uc003cow.2_5'UTR|SLC6A20_uc011baj.1_Nonsense_Mutation_p.S214*	NM_020208	NP_064593	Q9NP91	S6A20_HUMAN	solute carrier family 6, member 20 isoform 1	251	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CAGGCCAAGTGAGAAGAAGAT	0.587													0	0	0	0.008291	0	11	30										C	45812892	G	C	45812892	4	2	128	1	0	0	0	0	0	1	0	0	14684	1294	45	1	1050	1	SLC6A20	3	45812892	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1049369	45812892	152209538	74	38113										
CSPG5	10675	broad.mit.edu	37	chr3	47604194	47604194	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctggatgttaaatgactcctCctctttcaggcaggacttga	9	10	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:47604194C>A	uc003crp.3	-	5	1773	c.1597G>T	c.(1597-1599)GAG>TAG	p.E533*	CSPG5_uc003crm.2_RNA|CSPG5_uc003crn.2_Nonsense_Mutation_p.E368*|CSPG5_uc003cro.3_Nonsense_Mutation_p.E506*|CSPG5_uc011bbb.1_Nonsense_Mutation_p.E395*	NM_006574	NP_006565	O95196	CSPG5_HUMAN	chondroitin sulfate proteoglycan 5 (neuroglycan	533	Cytoplasmic (Potential).				cell differentiation|intracellular transport|nervous system development|regulation of growth	endoplasmic reticulum membrane|Golgi-associated vesicle membrane|integral to plasma membrane|membrane fraction	growth factor activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000266)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AATGACTCCTCCTCTTTCAGG	0.488													1	0	3.32936e-07	0.006122	3.71887e-07	19	78										A	47604194	C	A	47604194	4	1	128	1	0	0	0	0	0	1	0	0	3961	864	30	3	107	3	CSPG5	3	47604194	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1791302	47604194	150418236	75	38114										
SEMA3F	6405	broad.mit.edu	37	chr3	50197151	50197151	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctcccggccacgccccgggtCcggctctcattcaaaggtaa	10	17	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:50197151C>T	uc003cyj.2	+	2	294	c.96C>T	c.(94-96)GTC>GTT	p.V32V	SEMA3F_uc003cyk.2_Silent_p.V32V	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	32	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CGCCCCGGGTCCGGCTCTCAT	0.587													0	0	0	0.000602	0	5	22										T	50197151	C	T	50197151	2	4	128	1	0	0	0	0	0	0	0	1	14029	842	30	1		1	SEMA3F	3	50197151	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2592957	50197151	147825279	76	38115										
SEMA3B	7869	broad.mit.edu	37	chr3	50311844	50311844	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tccaccaaggacttcccagaCgatgtcatccagtttgcgcg	9	14	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:50311844C>A	uc003cyu.2	+	13	1430	c.1188C>A	c.(1186-1188)GAC>GAA	p.D396E	SEMA3B_uc003cyt.2_Missense_Mutation_p.D395E|SEMA3B_uc003cyv.2_Missense_Mutation_p.D283E|SEMA3B_uc003cyw.2_Missense_Mutation_p.D119E|SEMA3B_uc010hli.2_Missense_Mutation_p.D288E|SEMA3B_uc003cyx.2_Missense_Mutation_p.D282E|SEMA3B_uc003cyy.2_Missense_Mutation_p.D53E|SEMA3B_uc011bdo.1_Missense_Mutation_p.D53E	NM_004636	NP_004627	Q13214	SEM3B_HUMAN	semaphorin 3B isoform 1 precursor	396	Sema.				axon guidance|cell-cell signaling	endoplasmic reticulum|extracellular region|membrane	receptor activity			lung(2)|central_nervous_system(2)|kidney(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		ACTTCCCAGACGATGTCATCC	0.572											OREG0015583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.9806e-07	0.014323	2.23095e-07	21	76										A	50311844	C	A	50311844	3	1	128	1	0	0	0	0	1	0	0	0	14025	535	19	4	1229	4	SEMA3B	3	50311844	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	114693	50311844	147710586	77	38116										
DNAH1	25981	broad.mit.edu	37	chr3	52400859	52400859	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctcaaccccaagtccatcacGatgggccagctgtacgggga	11	14	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:52400859G>T	uc011bef.1	+	36	5982	c.5721G>T	c.(5719-5721)ACG>ACT	p.T1907T		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1907	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGTCCATCACGATGGGCCAGC	0.607													1	0	5.16669e-11	0.010729	6.02279e-11	9	59										T	52400859	G	T	52400859	2	4	128	1	0	0	0	0	0	0	0	1	4597	1045	37	3		3	DNAH1	3	52400859	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2089015	52400859	145621571	78	38117										
ARL13B	200894	broad.mit.edu	37	chr3	93699277	93699277	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agcgacccgggatgttcagtCtgatggccagttgctgcggc	15	11	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:93699277C>G	uc003drc.2	+	1	296	c.10C>G	c.(10-12)CTG>GTG	p.L4V	ARL13B_uc010hop.2_5'UTR|ARL13B_uc003drd.2_Missense_Mutation_p.L4V|ARL13B_uc003dre.2_5'UTR|ARL13B_uc003drf.2_Missense_Mutation_p.L4V|ARL13B_uc003drg.2_5'UTR	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	4							GTP binding				0						GATGTTCAGTCTGATGGCCAG	0.692													0	0	0	0.004007	0	13	74										G	93699277	C	G	93699277	3	3	128	1	0	0	0	0	1	0	0	0	929	912	32	1	12	1	ARL13B	3	93699277	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	41298418	93699277	104323153	79	38118										
PARP14	54625	broad.mit.edu	37	chr3	122420202	122420202	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctttcccttaggccgatgcgTggagaccattgtttctgcca	10	12	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:122420202T>G	uc003efq.3	+	6	2860	c.2801T>G	c.(2800-2802)GTG>GGG	p.V934G	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.V651G|PARP14_uc003efs.1_Missense_Mutation_p.V651G	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	934	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		GGCCGATGCGTGGAGACCATT	0.448													0	0	0	0.004482	0	8	51										G	122420202	T	G	122420202	3	3	128	1	0	0	0	0	1	0	0	0	11458	1696	59	5	2823	5	PARP14	3	122420202	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	28720925	122420202	75602228	80	38119										
HSPBAP1	79663	broad.mit.edu	37	chr3	122459597	122459597	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acatttaattcttcctttttCatgtgctctccatctgttct	3	11	5	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:122459597C>A	uc003efu.1	-	8	1185	c.1062G>T	c.(1060-1062)ATG>ATT	p.M354I	HSPBAP1_uc003eft.1_Missense_Mutation_p.M65I	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	354						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		CTTCCTTTTTCATGTGCTCTC	0.458													1	0	1.33834e-09	0.007413	1.54661e-09	17	236										A	122459597	C	A	122459597	3	1	128	1	0	0	0	0	1	0	0	0	7425	826	29	3	408	3	HSPBAP1	3	122459597	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	39395	122459597	75562833	81	38120										
MYLK	4638	broad.mit.edu	37	chr3	123451827	123451827	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgtcccactgtccctggtccGggctttcagcaggcagaggt	13	13	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:123451827G>C	uc003ego.2	-	11	1714	c.1432C>G	c.(1432-1434)CGG>GGG	p.R478G	MYLK_uc011bjw.1_Missense_Mutation_p.R478G|MYLK_uc003egp.2_Intron|MYLK_uc003egq.2_Missense_Mutation_p.R478G|MYLK_uc003egr.2_Intron|MYLK_uc003egs.2_Missense_Mutation_p.R302G	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	478	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCCCTGGTCCGGGCTTTCAGC	0.577													0	0	0	0.001984	0	6	44										C	123451827	G	C	123451827	3	2	128	1	0	0	0	0	1	0	0	0	10056	1115	39	4	4408	4	MYLK	3	123451827	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	992230	123451827	74570603	82	38121										
ROPN1	54763	broad.mit.edu	37	chr3	123688915	123688915	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgttccatgtagtttagcatCctgctgacatgtgatgcaga	10	8	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:123688915C>A	uc003eha.2	-	6	887	c.546G>T	c.(544-546)AGG>AGT	p.R182S		NM_017578	NP_060048	Q9HAT0	ROP1A_HUMAN	ropporin	182					signal transduction		cAMP-dependent protein kinase regulator activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.148)		AGTTTAGCATCCTGCTGACAT	0.453													1	0	1.76689e-08	0.006214	2.02436e-08	10	98										A	123688915	C	A	123688915	3	1	128	1	0	0	0	0	1	0	0	0	13523	854	30	3	100	3	ROPN1	3	123688915	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	237088	123688915	74333515	83	38122										
KALRN	8997	broad.mit.edu	37	chr3	124209673	124209673	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgagatctccttggtttttaGcaaggagatcaaagattctt	9	6	3	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:124209673G>A	uc003ehg.2	+	30	4650	c.4523G>A	c.(4522-4524)AGC>AAC	p.S1508N	KALRN_uc010hrv.1_Missense_Mutation_p.S1499N|KALRN_uc003ehf.1_Missense_Mutation_p.S1508N|KALRN_uc011bjy.1_Missense_Mutation_p.S1499N	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1508	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TTGGTTTTTAGCAAGGAGATC	0.498													0	0	0	0.003954	0	26	54										A	124209673	G	A	124209673	3	1	128	1	0	0	0	0	1	0	0	0	7975	971	34	2	4641	2	KALRN	3	124209673	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	520758	124209673	73812757	84	38123										
OSBPL11	114885	broad.mit.edu	37	chr3	125250824	125250824	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggccttatcaatttcagattCtctcagcgagtctgtcacat	7	11	6	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:125250824C>T	uc003eic.2	-	12	2796	c.2059G>A	c.(2059-2061)GAA>AAA	p.E687K		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	687					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						ATTTCAGATTCTCTCAGCGAG	0.393													0	0	0	0.00499	0	16	72										T	125250824	C	T	125250824	3	4	128	1	0	0	0	0	1	0	0	0	11276	922	32	1	192	1	OSBPL11	3	125250824	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1041151	125250824	72771606	85	38124										
A4GNT	51146	broad.mit.edu	37	chr3	137843555	137843555	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaggaacccaaatattccatTactagagtaccgagaagcct	8	10	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:137843555T>A	uc003ers.2	-	3	776	c.574A>T	c.(574-576)AAT>TAT	p.N192Y		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	192	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						AATATTCCATTACTAGAGTAC	0.498													0	0	0	0.006214	0	8	89										A	137843555	T	A	137843555	3	1	128	1	0	0	0	0	1	0	0	0	7	1754	61	5	452	5	A4GNT	3	137843555	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	12592731	137843555	60178875	86	38125										
RARRES1	5918	broad.mit.edu	37	chr3	158428666	158428666	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggtctgggtttctgattcttGaaaaacactcgagcagaaca	10	8	3	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:158428666G>C	uc003fci.2	-	3	467	c.396C>G	c.(394-396)TTC>TTG	p.F132L	RARRES1_uc003fcj.2_Missense_Mutation_p.F132L	NM_206963	NP_996846	P49788	TIG1_HUMAN	retinoic acid receptor responder (tazarotene	132	Extracellular (Potential).				negative regulation of cell proliferation	integral to membrane					0			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)		Tretinoin(DB00755)	TCTGATTCTTGAAAAACACTC	0.428													0	0	0	0.01441	0	48	123										C	158428666	G	C	158428666	3	2	128	1	0	0	0	0	1	0	0	0	13055	1281	45	1	519	1	RARRES1	3	158428666	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	20585111	158428666	39593764	87	38126										
SEC62	7095	broad.mit.edu	37	chr3	169710730	169710730	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccagcacagtagtggaaatgGaaatgattttgaaatgataa	10	4	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:169710730G>A	uc003fgg.2	+	8	1110	c.1079G>A	c.(1078-1080)GGA>GAA	p.G360E	SEC62_uc003fgh.2_Missense_Mutation_p.G360E	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	360	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						AGTGGAAATGGAAATGATTTT	0.458													0	0	0	0.009096	0	4	39										A	169710730	G	A	169710730	3	1	128	1	0	0	0	0	1	0	0	0	14004	1174	41	1	1109	1	SEC62	3	169710730	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	11282064	169710730	28311700	88	38127										
PIK3CA	5290	broad.mit.edu	37	chr3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctacacgagatcctctctctGaaatcactgagcaggagaaa	8	11	3	4	rs121913273		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.004007	0	15	52										A	178936082	G	A	178936082	3	1	128	1	0	0	0	0	1	0	0	0	11913	1291	45	1	1658	1	PIK3CA	3	178936082	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9225352	178936082	19086348	89	38128										
MCF2L2	23101	broad.mit.edu	37	chr3	183029466	183029466	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tagttacattctcaagttggTtgagattgagtttgctgttg	11	4	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:183029466T>A	uc003fli.1	-	8	938	c.848A>T	c.(847-849)AAC>ATC	p.N283I	MCF2L2_uc003flj.1_Missense_Mutation_p.N283I|MCF2L2_uc003flp.1_Missense_Mutation_p.N318I|MCF2L2_uc011bqs.1_5'Flank	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	283					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CTCAAGTTGGTTGAGATTGAG	0.438													0	0	0	0.012213	0	35	72										A	183029466	T	A	183029466	3	1	128	1	0	0	0	0	1	0	0	0	9380	1725	60	5	2588	5	MCF2L2	3	183029466	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	4093384	183029466	14992964	90	38129										
AHSG	197	broad.mit.edu	37	chr3	186335076	186335076	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcgaaagctgccctggccgcCttcaacgctcagaacaacgg	11	15	2	1	rs78152999	byFrequency	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:186335076C>T	uc003fqk.3	+	4	591	c.510C>T	c.(508-510)GCC>GCT	p.A170A	AHSG_uc003fqj.2_Silent_p.A170A|AHSG_uc003fql.3_Silent_p.A171A|AHSG_uc003fqm.3_Silent_p.A169A|AHSG_uc010hyp.2_Silent_p.A133A	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	170	Cystatin fetuin-A-type 2.			PLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQL -> MVGW QEGANHKNGAGRSQKQEMAEKMVPEVASG (in Ref. 12; AAF69649).	acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		CCCTGGCCGCCTTCAACGCTC	0.592											OREG0015968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	10	83										T	186335076	C	T	186335076	2	4	128	1	0	0	0	0	0	0	0	1	420	668	24	2		2	AHSG	3	186335076	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3305610	186335076	11687354	91	38130										
ATP13A5	344905	broad.mit.edu	37	chr3	193007837	193007837	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agccagctttgggtaggcatGagttgaactcactgaaagac	12	8	1	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr3:193007837G>C	uc011bsq.1	-	26	2860	c.2860C>G	c.(2860-2862)CAT>GAT	p.H954D		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	954	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GGGTAGGCATGAGTTGAACTC	0.383													0	0	0	0.001984	0	6	64										C	193007837	G	C	193007837	3	2	128	1	0	0	0	0	1	0	0	0	1127	1290	45	1	814	1	ATP13A5	3	193007837	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	6672761	193007837	5014593	92	38131										
KDR	3791	broad.mit.edu	37	chr4	55961065	55961065	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gctgtccaagcgccgtttcaGatccacagggattgctccaa	10	13	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr4:55961065G>C	uc003has.2	-	21	3177	c.2875C>G	c.(2875-2877)CTG>GTG	p.L959V	KDR_uc003hat.1_Missense_Mutation_p.L959V	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	959	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CGCCGTTTCAGATCCACAGGG	0.478			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			0	0	0	0.010729	0	12	61										C	55961065	G	C	55961065	3	2	128	1	0	0	0	0	1	0	0	0	8139	933	33	1	1235	1	KDR	4	55961065	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		55961065	135193211	93	38132										
HTN1	3346	broad.mit.edu	37	chr4	70920139	70920139	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttttctttttatttcatagaGacatcatgggtatagaagaa	7	4	3	3	rs78945345		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr4:70920139G>A	uc003hex.2	+	4	141	c.74G>A	c.(73-75)AGA>AAA	p.R25K		NM_002159	NP_002150	P15515	HIS1_HUMAN	histatin 1 precursor	25					biomineral tissue development|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular region	protein binding			skin(1)	1						ATTTCATAGAGACATCATGGG	0.289													0	0	0	0.001168	0	6	15										A	70920139	G	A	70920139	3	1	128	1	0	0	0	0	1	0	0	0	7434	956	33	1	84	1	HTN1	4	70920139	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	14959074	70920139	120234137	94	38133										
GRIA2	2891	broad.mit.edu	37	chr4	158283999	158283999	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acgttgctggagtattctacAtccttgtcgggggccttggt	13	9	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr4:158283999A>G	uc003ipm.3	+	15	2914	c.2455A>G	c.(2455-2457)ATC>GTC	p.I819V	GRIA2_uc011cit.1_Missense_Mutation_p.I772V|GRIA2_uc003ipl.3_Missense_Mutation_p.I819V|GRIA2_uc003ipk.3_Missense_Mutation_p.I772V|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_3'UTR|GRIA2_uc011ciy.1_3'UTR|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	819	Helical; (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGTATTCTACATCCTTGTCGG	0.468													0	0	0	0.001984	0	7	51										G	158283999	A	G	158283999	3	3	128	1	0	0	0	0	1	0	0	0	6768	217	8	5	2632	5	GRIA2	4	158283999	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	87363860	158283999	32870277	95	38134										
VEGFC	7424	broad.mit.edu	37	chr4	177713384	177713384	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggactcgaaggcggcggcggCggcgggcgcctcgcgaggac	21	13	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr4:177713384C>G	uc003ius.1	-	1	512	c.82G>C	c.(82-84)GCC>CCC	p.A28P		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	28					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		gcggcggcggcggcgggcgcc	0.562													0	0	0	0.004672	0	3	14										G	177713384	C	G	177713384	3	3	128	1	0	0	0	0	1	0	0	0	17149	768	27	4	1208	4	VEGFC	4	177713384	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	19429385	177713384	13440892	96	38135										
FAT1	2195	broad.mit.edu	37	chr4	187524560	187524560	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgtgcagaagttgttttgttGagatctgagcactacctggt	12	6	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr4:187524560G>T	uc003izf.2	-	19	11308	c.11120C>A	c.(11119-11121)TCA>TAA	p.S3707*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3707	Extracellular (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTGTTTTGTTGAGATCTGAGC	0.433										HNSCC(5;0.00058)			1	0	1.58986e-06	0.008291	1.76115e-06	10	28										T	187524560	G	T	187524560	4	4	128	1	0	0	0	0	0	1	0	0	5689	1294	45	3	2682	3	FAT1	4	187524560	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9811176	187524560	3629716	97	38136										
TAS2R1	50834	broad.mit.edu	37	chr5	9629419	9629419	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaagagagaaaaacttttatCatgcagtgggagaagtagag	13	3	1	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:9629419C>A	uc003jem.1	-	1	1045	c.726G>T	c.(724-726)ATG>ATT	p.M242I		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	242	Helical; Name=6; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						AAACTTTTATCATGCAGTGGG	0.478													1	0	4.68919e-08	0.008291	5.31177e-08	10	50										A	9629419	C	A	9629419	3	1	128	1	0	0	0	0	1	0	0	0	15562	826	29	3	177	3	TAS2R1	5	9629419	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		9629419	171285841	98	38137										
TRIO	7204	broad.mit.edu	37	chr5	14399063	14399063	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagtgtgggacccaaaaaccTtaattcgaaagggtcgagaa	11	7	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:14399063T>G	uc003jff.2	+	30	4504	c.4498T>G	c.(4498-4500)TTA>GTA	p.L1500V	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.L1451V|TRIO_uc003jfh.1_Missense_Mutation_p.L1149V	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	1500	PH 1.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CCCAAAAACCTTAATTCGAAA	0.408													0	0	0	0.004007	0	17	68										G	14399063	T	G	14399063	3	3	128	1	0	0	0	0	1	0	0	0	16549	1606	56	5	4616	5	TRIO	5	14399063	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	4769644	14399063	166516197	99	38138										
CWC27	10283	broad.mit.edu	37	chr5	64314141	64314141	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gatgagagagaaaaaagaaaGaagataaaatgagaataatg	11	0	0	6	rs143234808		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:64314141G>C	uc003jtn.1	+	14	1631	c.1412G>C	c.(1411-1413)AGA>ACA	p.R471T	CWC27_uc010iwt.1_3'UTR	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	471					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						AAAAAAGAAAGAAGATAAAAT	0.388													0	0	0	0.00245	0	14	44										C	64314141	G	C	64314141	3	2	128	1	0	0	0	0	1	0	0	0	4070	942	33	1	1466	1	CWC27	5	64314141	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	49915078	64314141	116601119	100	38139										
OCLN	4950	broad.mit.edu	37	chr5	68805240	68805240	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgtaggctacccttatggagGaagtggctttggtagctacg	14	7	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:68805240G>A	uc003jwu.2	+	3	759	c.323G>A	c.(322-324)GGA>GAA	p.G108E	OCLN_uc003jwv.3_Missense_Mutation_p.G108E	NM_002538	NP_002529			occludin												0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CCTTATGGAGGAAGTGGCTTT	0.438													0	0	0	0.00499	0	18	96										A	68805240	G	A	68805240	3	1	128	1	0	0	0	0	1	0	0	0	10820	1174	41	1	329	1	OCLN	5	68805240	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4491099	68805240	112110020	101	38140										
DMGDH	29958	broad.mit.edu	37	chr5	78359611	78359611	+	Splice_Site	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ataagggtggtttttcctctCtggaagagggaaagttaaaa	12	4	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:78359611C>G	uc003kfs.2	-	2	108	c.102_splice	c.e2-1	p.G34_splice	DMGDH_uc011ctf.1_Splice_Site|DMGDH_uc011ctg.1_Splice_Site	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor						choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TTTTTCCTCTCTGGAAGAGGG	0.448													0	0	0	0.001855	0	13	54										G	78359611	C	G	78359611	5	3	128	1	0	0	0	0	0	0	1	0	4581	927	32	1	2559	1	DMGDH	5	78359611	Splice_Site	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	9554371	78359611	102555649	102	38141										
VCAN	1462	broad.mit.edu	37	chr5	82835422	82835422	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acaactctccctgaagctacTgaaaagtcacattttttctt	4	11	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:82835422T>A	uc003kii.3	+	8	6956	c.6600T>A	c.(6598-6600)ACT>ACA	p.T2200T	VCAN_uc003kij.3_Silent_p.T1213T|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.T864T	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2200	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTGAAGCTACTGAAAAGTCAC	0.368													0	0	0	0.004007	0	17	90										A	82835422	T	A	82835422	2	1	128	1	0	0	0	0	0	0	0	1	17135	1567	55	5		5	VCAN	5	82835422	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	4475811	82835422	98079838	103	38142										
AQPEP	206338	broad.mit.edu	37	chr5	115350145	115350145	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tggaaaaactttttgtaactGcgtgttggttgggccttgaa	12	5	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:115350145G>A	uc003kro.2	+	16	2535	c.2371G>A	c.(2371-2373)GCG>ACG	p.A791T	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	791	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TTTTGTAACTGCGTGTTGGTT	0.358													0	0	0	0.000602	0	5	55										A	115350145	G	A	115350145	3	1	128	1	0	0	0	0	1	0	0	0	834	1319	46	2	2433	2	AQPEP	5	115350145	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	32514723	115350145	65565115	104	38143										
SEPT8	23176	broad.mit.edu	37	chr5	132098183	132098183	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acccaacgctcacattcatgActgcgttaatctctgcaaca	5	14	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:132098183A>T	uc003kxr.2	-	5	927	c.689T>A	c.(688-690)GTC>GAC	p.V230D	SEPT8_uc003kxs.1_Missense_Mutation_p.V230D|SEPT8_uc003kxu.2_Missense_Mutation_p.V230D|SEPT8_uc011cxi.1_Missense_Mutation_p.V228D|SEPT8_uc003kxv.2_Missense_Mutation_p.V228D|SEPT8_uc003kxt.2_Missense_Mutation_p.V170D	NM_001098811	NP_001092281	Q92599	SEPT8_HUMAN	septin 8 isoform a	230					cell cycle	septin complex	GTP binding|protein binding			ovary(2)	2		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CACATTCATGACTGCGTTAAT	0.577													0	0	0	0.006214	0	8	56										T	132098183	A	T	132098183	3	4	128	1	0	0	0	0	1	0	0	0	14070	275	10	5	841	5	SEPT8	5	132098183	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	16748038	132098183	48817077	105	38144										
C5orf24	134553	broad.mit.edu	37	chr5	134191113	134191113	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcatggcagagcagttcatGgggtagaggaaactagcagt	15	6	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:134191113G>T	uc003kzx.2	+	2	584	c.523G>T	c.(523-525)GGG>TGG	p.G175W	C5orf24_uc003kzy.3_Intron|C5orf24_uc003kzz.2_Missense_Mutation_p.G175W	NM_152409	NP_689622	Q7Z6I8	CE024_HUMAN	hypothetical protein LOC134553	175											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCAGTTCATGGGGTAGAGGA	0.478													1	0	4.36969e-10	0.001855	5.07897e-10	14	49										T	134191113	G	T	134191113	3	4	128	1	0	0	0	0	1	0	0	0	2287	1348	47	4	525	4	C5orf24	5	134191113	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2092930	134191113	46724147	106	38145										
AFAP1L1	134265	broad.mit.edu	37	chr5	148695811	148695811	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	attggcttctccaagaagaaGacactggccgatgacctgca	10	11	1	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:148695811G>C	uc003lqh.2	+	11	1343	c.1212G>C	c.(1210-1212)AAG>AAC	p.K404N	AFAP1L1_uc010jgy.2_Missense_Mutation_p.K404N|AFAP1L1_uc003lqi.1_Missense_Mutation_p.K19N	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	404							protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCAAGAAGAAGACACTGGCCG	0.612													0	0	0	0.001984	0	5	68										C	148695811	G	C	148695811	3	2	128	1	0	0	0	0	1	0	0	0	354	933	33	1	1254	1	AFAP1L1	5	148695811	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	14504698	148695811	32219449	107	38146										
CSF1R	1436	broad.mit.edu	37	chr5	149433917	149433917	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtcctcttgggcctgctcctGaaggaaggagcagatctgct	13	11	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:149433917G>C	uc003lrl.2	-	20	2926	c.2731C>G	c.(2731-2733)CAG>GAG	p.Q911E	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.Q911E	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	911	Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GCCTGCTCCTGAAGGAAGGAG	0.622													0	0	0	0.008871	0	19	35										C	149433917	G	C	149433917	3	2	128	1	0	0	0	0	1	0	0	0	3932	1299	45	1	195	1	CSF1R	5	149433917	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	738106	149433917	31481343	108	38147										
FAT2	2196	broad.mit.edu	37	chr5	150901299	150901299	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctcctgccccacatgccacaCgtacacatggaccccagcag	7	19	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:150901299C>A	uc003lue.3	-	18	10868	c.10855G>T	c.(10855-10857)GTG>TTG	p.V3619L	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.V312L	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3619	Cadherin 32.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACATGCCACACGTACACATGG	0.627													1	0	0.000602214	0.000602	0.000635495	5	28										A	150901299	C	A	150901299	3	1	128	1	0	0	0	0	1	0	0	0	5690	536	19	4	2218	4	FAT2	5	150901299	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1467382	150901299	30013961	109	38148										
RPL26L1	51121	broad.mit.edu	37	chr5	172396492	172396492	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agccaagtctcgacaagttgGaaaagagaaaggcaaatata	10	6	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:172396492G>C	uc003mcc.2	+	4	428	c.386G>C	c.(385-387)GGA>GCA	p.G129A		NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	129					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CGACAAGTTGGAAAAGAGAAA	0.408													0	0	0	0.000602	0	5	95										C	172396492	G	C	172396492	3	2	128	1	0	0	0	0	1	0	0	0	13574	1174	41	1	396	1	RPL26L1	5	172396492	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	21495193	172396492	8518768	110	38149										
TRIM41	90933	broad.mit.edu	37	chr5	180661586	180661586	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cagagctccacagaacagacGctgctgagccccagtgagaa	11	13	0	5			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr5:180661586G>A	uc003mne.1	+	6	2398	c.1704G>A	c.(1702-1704)ACG>ACA	p.T568T	TRIM41_uc003mnc.1_3'UTR|TRIM41_uc003mnd.1_Intron|TRIM41_uc003mnf.1_Intron|TRIM41_uc003mng.1_Silent_p.T148T	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	568	B30.2/SPRY.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGAACAGACGCTGCTGAGCC	0.632													0	0	0	0.000602	0	5	58										A	180661586	G	A	180661586	2	1	128	1	0	0	0	0	0	0	0	1	16513	1074	38	2		2	TRIM41	5	180661586	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	8265094	180661586	253674	111	38150										
PRL	5617	broad.mit.edu	37	chr6	22294754	22294754	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agccccgccgggacagatggGcaagggggccacgctctggc	17	14	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:22294754G>C	uc003ndp.2	-	2	607	c.88C>G	c.(88-90)CCC>GCC	p.P30A	PRL_uc003ndo.2_Missense_Mutation_p.P31A|PRL_uc003ndq.2_Missense_Mutation_p.P30A|PRL_uc003ndr.1_RNA	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	30					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)					GGACAGATGGGCAAGGGGGCC	0.592													0	0	0	0.009096	0	4	30										C	22294754	G	C	22294754	3	2	128	1	0	0	0	0	1	0	0	0	12528	1203	42	4	611	4	PRL	6	22294754	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		22294754	148820313	112	38151										
C6orf10	10665	broad.mit.edu	37	chr6	32261017	32261017	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctgtccttttagtacacctGactcactcttctttacttgg	5	13	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:32261017G>A	uc011dpy.1	-	12	1606	c.1433C>T	c.(1432-1434)TCA>TTA	p.S478L	C6orf10_uc011dpx.1_Intron	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	478	Lys-rich.					integral to membrane				skin(1)	1						TAGTACACCTGACTCACTCTT	0.338													0	0	0	0.00499	0	18	179										A	32261017	G	A	32261017	3	1	128	1	0	0	0	0	1	0	0	0	2317	1294	45	1	262	1	C6orf10	6	32261017	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9966263	32261017	138854050	113	38152										
DAXX	1616	broad.mit.edu	37	chr6	33288742	33288742	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttgttgatgagccgctcaatGcgcctgttaacctctgggta	11	10	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:33288742G>A	uc003oec.2	-	3	1014	c.810C>T	c.(808-810)CGC>CGT	p.R270R	DAXX_uc011drd.1_Silent_p.R195R|DAXX_uc011dre.1_Silent_p.R282R|DAXX_uc003oed.2_Silent_p.R270R|DAXX_uc010juw.2_Silent_p.R195R	NM_001350	NP_001341	Q9UER7	DAXX_HUMAN	death-domain associated protein isoform a	270					activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding			pancreas(18)|ovary(2)|skin(2)|prostate(1)	23						GCCGCTCAATGCGCCTGTTAA	0.597			Mis|F|N		Pancreatic neuroendocrine tumors								0	0	0	0.00623	0	41	59										A	33288742	G	A	33288742	2	1	128	1	0	0	0	0	0	0	0	1	4243	1306	46	2		2	DAXX	6	33288742	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1027725	33288742	137826325	114	38153										
BRPF3	27154	broad.mit.edu	37	chr6	36168216	36168216	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acatatgcccaggcccagcgGattgtcgaggtagacattga	12	10	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:36168216G>A	uc003olv.3	+	2	341	c.117G>A	c.(115-117)CGG>CGA	p.R39R	BRPF3_uc010jwb.2_Silent_p.R39R|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.R39R	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	39					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						AGGCCCAGCGGATTGTCGAGG	0.572													0	0	0	0.009096	0	4	65										A	36168216	G	A	36168216	2	1	128	1	0	0	0	0	0	0	0	1	1521	1161	41	1		1	BRPF3	6	36168216	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2879474	36168216	134946851	115	38154										
PPP2R5D	5528	broad.mit.edu	37	chr6	42974675	42974675	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	caacccaggagcgggaggagCtgtttatccagaagctacgc	13	11	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:42974675C>T	uc003oth.2	+	4	435	c.349C>T	c.(349-351)CTG>TTG	p.L117L	MEA1_uc010jyc.1_Intron|PPP2R5D_uc003otg.2_Silent_p.L85L|PPP2R5D_uc010jyd.2_Silent_p.L11L|PPP2R5D_uc011dva.1_5'UTR|PPP2R5D_uc003oti.2_5'UTR|PPP2R5D_uc003otj.2_5'UTR	NM_006245	NP_006236	Q14738	2A5D_HUMAN	delta isoform of regulatory subunit B56, protein	117					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(1)|central_nervous_system(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCGGGAGGAGCTGTTTATCCA	0.562													0	0	0	0.004656	0	24	151										T	42974675	C	T	42974675	2	4	128	1	0	0	0	0	0	0	0	1	12395	796	28	2		2	PPP2R5D	6	42974675	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	6806459	42974675	128140392	116	38155										
SLC35B2	347734	broad.mit.edu	37	chr6	44224183	44224183	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aacctcatcagaggccttggGctcattgccaaacacacaag	8	13	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:44224183G>A	uc003oxd.2	-	3	392	c.256C>T	c.(256-258)CCC>TCC	p.P86S	SLC35B2_uc011dvt.1_Intron|SLC35B2_uc011dvu.1_Intron	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	solute carrier family 35, member B2	86					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAGGCCTTGGGCTCATTGCCA	0.577													0	0	0	0.008291	0	11	75										A	44224183	G	A	44224183	3	1	128	1	0	0	0	0	1	0	0	0	14576	1203	42	2	1050	2	SLC35B2	6	44224183	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1249508	44224183	126890884	117	38156										
CRISP2	7180	broad.mit.edu	37	chr6	49666126	49666126	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctctttggtcctacaccataGacaaaatctaggatctcgtc	6	12	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:49666126G>A	uc003ozq.2	-	7	622	c.366C>T	c.(364-366)GTC>GTT	p.V122V	CRISP2_uc003ozl.2_Silent_p.V122V|CRISP2_uc003ozn.2_Silent_p.V122V|CRISP2_uc003ozr.2_Silent_p.V122V|CRISP2_uc003ozo.2_Silent_p.V122V|CRISP2_uc003ozm.2_Silent_p.V122V|CRISP2_uc003ozp.2_Silent_p.V122V	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	122						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTACACCATAGACAAAATCTA	0.413													0	0	0	0.010729	0	11	69										A	49666126	G	A	49666126	2	1	128	1	0	0	0	0	0	0	0	1	3880	929	33	1		1	CRISP2	6	49666126	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	5441943	49666126	121448941	118	38157										
TTK	7272	broad.mit.edu	37	chr6	80746227	80746227	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atcttaaaccagctaactttCtgatagttgatggaatgcta	7	7	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:80746227C>G	uc003pjc.2	+	17	2034	c.1960C>G	c.(1960-1962)CTG>GTG	p.L654V	TTK_uc003pjb.3_Missense_Mutation_p.L653V	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	654	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AGCTAACTTTCTGATAGTTGA	0.318													0	0	0	0.000602	0	5	59										G	80746227	C	G	80746227	3	3	128	1	0	0	0	0	1	0	0	0	16717	912	32	1	2022	1	TTK	6	80746227	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	31080101	80746227	90368840	119	38158										
DOPEY1	23033	broad.mit.edu	37	chr6	83834892	83834892	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tctcattttgaagcctactaGaagtatgagggtgctgtgtc	11	7	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:83834892G>C	uc003pjs.1	+	14	1723	c.1463G>C	c.(1462-1464)AGA>ACA	p.R488T	DOPEY1_uc011dyy.1_Missense_Mutation_p.R479T|DOPEY1_uc010kbl.1_Missense_Mutation_p.R479T	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	488					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAGCCTACTAGAAGTATGAGG	0.284													0	0	0	0.000602	0	4	34										C	83834892	G	C	83834892	3	2	128	1	0	0	0	0	1	0	0	0	4707	942	33	1	1509	1	DOPEY1	6	83834892	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3088665	83834892	87280175	120	38159										
SIM1	6492	broad.mit.edu	37	chr6	100838763	100838763	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cagccccattaatggaagccAgttggtctgagggggctttc	13	10	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:100838763A>T	uc003pqj.3	-	11	1982	c.1775T>A	c.(1774-1776)CTG>CAG	p.L592Q	SIM1_uc010kcu.2_Missense_Mutation_p.L592Q	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	592	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		AATGGAAGCCAGTTGGTCTGA	0.468													0	0	0	0.00308	0	8	65										T	100838763	A	T	100838763	3	4	128	1	0	0	0	0	1	0	0	0	14323	188	7	5	529	5	SIM1	6	100838763	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	17003871	100838763	70276304	121	38160										
C6orf170	221322	broad.mit.edu	37	chr6	121562637	121562637	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tttttagtgcaatgccacctGctgctgttgatgccactcgt	9	11	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:121562637G>C	uc003pyo.1	-	19	2287	c.2219C>G	c.(2218-2220)GCA>GGA	p.A740G	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Missense_Mutation_p.A259G	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	740					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		AATGCCACCTGCTGCTGTTGA	0.338													0	0	0	0.001168	0	6	27										C	121562637	G	C	121562637	3	2	128	1	0	0	0	0	1	0	0	0	2344	1319	46	4	1610	4	C6orf170	6	121562637	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	20723874	121562637	49552430	122	38161										
NKAIN2	154215	broad.mit.edu	37	chr6	124979332	124979332	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgtaaattgccttcttgcagGaaacagaccttatcctgact	7	10	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:124979332G>C	uc003pzo.2	+	4	551	c.274G>C	c.(274-276)GAA>CAA	p.E92Q	NKAIN2_uc003pzn.1_Missense_Mutation_p.E92Q|NKAIN2_uc003pzp.2_Missense_Mutation_p.E91Q|NKAIN2_uc010keq.2_Intron|NKAIN2_uc010ker.2_Missense_Mutation_p.E2Q	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	92		Breakpoint for interstitial deletion to form SUSP1-NKAIN2.				integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		CTTCTTGCAGGAAACAGACCT	0.428													0	0	0	0.00308	0	8	38										C	124979332	G	C	124979332	3	2	128	1	0	0	0	0	1	0	0	0	10436	1188	41	1	288	1	NKAIN2	6	124979332	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3416695	124979332	46135735	123	38162										
GRM1	2911	broad.mit.edu	37	chr6	146755219	146755219	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccaagaccctttacaacgtaGaggaggaggaggatgcccag	13	10	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:146755219G>C	uc010khw.1	+	9	3342	c.2872G>C	c.(2872-2874)GAG>CAG	p.E958Q	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	958	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTACAACGTAGAGGAGGAGGA	0.582													0	0	0	0.010504	0	22	70										C	146755219	G	C	146755219	3	2	128	1	0	0	0	0	1	0	0	0	6796	943	33	1	2967	1	GRM1	6	146755219	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	21775887	146755219	24359848	124	38163										
TIAM2	26230	broad.mit.edu	37	chr6	155500249	155500249	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	caatgttgagtattgcatccCtgcaccatatgaatatatgc	7	9	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:155500249C>T	uc003qqb.2	+	13	3873	c.2600C>T	c.(2599-2601)CCT>CTT	p.P867L	TIAM2_uc003qqe.2_Missense_Mutation_p.P867L|TIAM2_uc010kjj.2_Missense_Mutation_p.P400L|TIAM2_uc003qqf.2_Missense_Mutation_p.P243L|TIAM2_uc011efl.1_Missense_Mutation_p.P203L|TIAM2_uc003qqg.2_Missense_Mutation_p.P179L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	867	RBD.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TATTGCATCCCTGCACCATAT	0.388													0	0	0	0.004007	0	15	51										T	155500249	C	T	155500249	3	4	128	1	0	0	0	0	1	0	0	0	15888	681	24	2	2630	2	TIAM2	6	155500249	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	8745030	155500249	15614818	125	38164										
TCP1	6950	broad.mit.edu	37	chr6	160205738	160205738	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttgagtgcatagccactgatGagcatactctccatttgact	8	10	1	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr6:160205738G>A	uc003qsr.2	-	6	865	c.630C>T	c.(628-630)CTC>CTT	p.L210L	TCP1_uc003qss.2_Silent_p.L55L|TCP1_uc010kjz.2_Silent_p.L210L|TCP1_uc003qst.2_Intron	NM_030752	NP_110379	P17987	TCPA_HUMAN	T-complex protein 1 isoform a	210					'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		AGCCACTGATGAGCATACTCT	0.413													0	0	0	0.006214	0	10	130										A	160205738	G	A	160205738	2	1	128	1	0	0	0	0	0	0	0	1	15706	1277	45	1		1	TCP1	6	160205738	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4705489	160205738	10909329	126	38165										
MPP6	51678	broad.mit.edu	37	chr7	24663374	24663374	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttttcctcaagggaattatgGagaatcctattgtaaaatca	7	6	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:24663374G>C	uc003swx.2	+	3	387	c.88G>C	c.(88-90)GAG>CAG	p.E30Q	MPP6_uc003swy.2_Missense_Mutation_p.E30Q	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	30	L27 1.				protein complex assembly		protein binding				0						GGGAATTATGGAGAATCCTAT	0.343													0	0	0	0.004482	0	7	36										C	24663374	G	C	24663374	3	2	128	1	0	0	0	0	1	0	0	0	9738	1175	41	1	90	1	MPP6	7	24663374	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		24663374	134475289	127	38166										
ABCA13	154664	broad.mit.edu	37	chr7	48312668	48312668	+	Silent	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcaaacctctcagcaaatgtCagtgtgttcaacaagtttat	6	9	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:48312668C>A	uc003toq.2	+	17	3430	c.3405C>A	c.(3403-3405)GTC>GTA	p.V1135V	ABCA13_uc010kyr.2_Silent_p.V638V	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1135					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CAGCAAATGTCAGTGTGTTCA	0.353													1	0	1.08611e-07	0.010729	1.22684e-07	12	27										A	48312668	C	A	48312668	2	1	128	1	0	0	0	0	0	0	0	1	31	813	29	3		3	ABCA13	7	48312668	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	23649294	48312668	110825995	128	38167										
DTX2	113878	broad.mit.edu	37	chr7	76126675	76126675	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	catgacgagtgttctgatgtCagccattggactccctgtgt	11	10	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:76126675C>T	uc003uff.3	+	7	1587	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L	DTX2_uc011kgk.1_Missense_Mutation_p.S253L|DTX2_uc003ufg.3_Missense_Mutation_p.S344L|DTX2_uc003ufh.3_Missense_Mutation_p.S344L|DTX2_uc003ufj.3_Intron|DTX2_uc003ufk.3_Intron|DTX2_uc003ufl.1_Missense_Mutation_p.S7L|DTX2_uc003ufm.3_5'Flank	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	344					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GTTCTGATGTCAGCCATTGGA	0.577													0	0	0	0.004656	0	22	138										T	76126675	C	T	76126675	3	4	128	1	0	0	0	0	1	0	0	0	4794	838	29	1	1045	1	DTX2	7	76126675	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	27814007	76126675	83011988	129	38168										
ZNF498	221785	broad.mit.edu	37	chr7	99226951	99226951	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gggtctgtgagcaggagcctGgtggccctgcaggcagtgcg	19	10	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:99226951G>C	uc003url.1	+	8	1270	c.943G>C	c.(943-945)GGT>CGT	p.G315R	ZNF498_uc003urm.1_Missense_Mutation_p.G151R|ZNF498_uc010lge.1_Missense_Mutation_p.G151R|ZNF498_uc003urn.2_Intron|ZNF498_uc010lgf.1_Missense_Mutation_p.G243R|ZNF498_uc003uro.1_Missense_Mutation_p.G99R	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25	315					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GCAGGAGCCTGGTGGCCCTGC	0.637													0	0	0	0.006214	0	9	56										C	99226951	G	C	99226951	3	2	128	1	0	0	0	0	1	0	0	0	17944	1348	47	4	961	4	ZNF498	7	99226951	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	23100276	99226951	59911712	130	38169										
MUC17	140453	broad.mit.edu	37	chr7	100675897	100675897	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccattaacaaatatgcctgtCagcaccatattggtggccag	8	11	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:100675897C>G	uc003uxp.1	+	3	1253	c.1200C>G	c.(1198-1200)GTC>GTG	p.V400V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	400	Extracellular (Potential).|59 X approximate tandem repeats.|4.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ATATGCCTGTCAGCACCATAT	0.463													0	0	0	0.01441	0	101	235										G	100675897	C	G	100675897	2	3	128	1	0	0	0	0	0	0	0	1	9974	813	29	1		1	MUC17	7	100675897	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1448946	100675897	58462766	131	38170										
MET	4233	broad.mit.edu	37	chr7	116371801	116371801	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	taccacagctttgcagcgcgTtgacttattcatgggtcaat	9	10	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:116371801T>G	uc003vij.2	+	3	1467	c.1280T>G	c.(1279-1281)GTT>GGT	p.V427G	MET_uc010lkh.2_Missense_Mutation_p.V427G|MET_uc011knc.1_Missense_Mutation_p.V427G|MET_uc011knd.1_Missense_Mutation_p.V427G|MET_uc011kne.1_Missense_Mutation_p.V427G|MET_uc011knf.1_Missense_Mutation_p.V427G|MET_uc011kng.1_Missense_Mutation_p.V427G|MET_uc011knh.1_Missense_Mutation_p.V427G|MET_uc011kni.1_Missense_Mutation_p.V427G|MET_uc011knj.1_5'UTR|MET_uc010lkg.2_Missense_Mutation_p.V427G|MET_uc011kna.1_Missense_Mutation_p.V427G|MET_uc011knb.1_Missense_Mutation_p.V427G	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	427	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTGCAGCGCGTTGACTTATTC	0.433			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.001168	0	5	42										G	116371801	T	G	116371801	3	3	128	1	0	0	0	0	1	0	0	0	9485	1725	60	5	1286	5	MET	7	116371801	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	15695904	116371801	42766862	132	38171										
CALD1	800	broad.mit.edu	37	chr7	134635196	134635196	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gctgagaaacgccagaagatGccagaagatggcttgtcaga	13	8	1	6			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:134635196G>A	uc003vrz.2	+	9	2325	c.1866G>A	c.(1864-1866)ATG>ATA	p.M622I	CALD1_uc003vry.2_Missense_Mutation_p.M367I|CALD1_uc003vsa.2_Missense_Mutation_p.M393I|CALD1_uc003vsb.2_Missense_Mutation_p.M367I|CALD1_uc010lmm.2_Missense_Mutation_p.M393I|CALD1_uc011kpt.1_Missense_Mutation_p.M141I|CALD1_uc003vsc.2_Missense_Mutation_p.M387I|CALD1_uc003vsd.2_Missense_Mutation_p.M361I|CALD1_uc011kpu.1_Missense_Mutation_p.M372I|CALD1_uc011kpv.1_Missense_Mutation_p.M231I|CALD1_uc003vse.2_Missense_Mutation_p.M486I	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	622					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						GCCAGAAGATGCCAGAAGATG	0.418													0	0	0	0.000602	0	5	58										A	134635196	G	A	134635196	3	1	128	1	0	0	0	0	1	0	0	0	2581	1319	46	2	1949	2	CALD1	7	134635196	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	18263395	134635196	24503467	133	38172										
OR2A12	346525	broad.mit.edu	37	chr7	143793122	143793127	+	In_Frame_Del	DEL	AGATCA	AGATCA	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agagagtcctttggaaacagAgatcaatgtgaagaatcatt							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:143793122_143793127delAGATCA	uc011kty.1	+	1	922_927	c.922_927delAGATCA	c.(922-927)AGATCAdel	p.RS308del		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	308_309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TTGGAAACAGAGATCAATGTGAAGAA	0.427																		7	141	---	---								-	143793127	AGATCA	-	143793122	7	5	128	1	0	1	0	1	0	0	0	0	10975	296	11	0	924	0	OR2A12	7	143793122	In_Frame_Del	DEL	AGATCA	TCGA-K4-A3WS-01A-11D-A22Z-08	9157926	143793122	15345541	134	38173										
NOM1	64434	broad.mit.edu	37	chr7	156743110	156743110	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgggagccctggagtctgggAaaaatagcggcttgtacgac	15	8	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr7:156743110A>G	uc003wmy.2	+	1	694	c.679A>G	c.(679-681)AAA>GAA	p.K227E		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	227	Necessary for nucleolar localization and for targeting PPP1CA to the nucleolus.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GGAGTCTGGGAAAAATAGCGG	0.522													0	0	0	0.004007	0	13	74										G	156743110	A	G	156743110	3	3	128	1	0	0	0	0	1	0	0	0	10530	247	9	5	681	5	NOM1	7	156743110	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	12949988	156743110	2395553	135	38174										
PSD3	23362	broad.mit.edu	37	chr8	18393456	18393456	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gagaatgctgacatacatttCatagcgggttttctgaaggc	11	7	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:18393456C>A	uc003wza.2	-	16	3044	c.2941G>T	c.(2941-2943)GAA>TAA	p.E981*	PSD3_uc003wyx.3_Nonsense_Mutation_p.E310*|PSD3_uc003wyy.2_Nonsense_Mutation_p.E447*|PSD3_uc003wyz.2_Nonsense_Mutation_p.E282*	NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	982					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACATACATTTCATAGCGGGTT	0.483													1	0	0.000673444	0.008291	0.00070694	10	38										A	18393456	C	A	18393456	4	1	128	1	0	0	0	0	0	1	0	0	12648	835	29	3	206	3	PSD3	8	18393456	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		18393456	127970566	136	38175										
KCNU1	157855	broad.mit.edu	37	chr8	36722033	36722034	+	Missense_Mutation	DNP	CC	CC	AG													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcgagcatatcaaacttcaCcaccaggtaaaagctgcaga							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:36722033_36722034CC>AG	uc010lvw.2	+	19	2090_2091	c.2003_2004CC>AG	c.(2002-2004)ACC>AAG	p.T668K	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	668	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCAAACTTCACCACCAGGTAAA	0.401													0	0	0	0.004672	0	25	54										AG	36722034	CC	AG	36722033	3	1	128	1	0	0	0	0	1	0	0	0	8093	507	18	4	2077	4	KCNU1	8	36722033	Missense_Mutation	DNP	CC	TCGA-K4-A3WS-01A-11D-A22Z-08	18328577	36722033	109641989	137	38176										
ANK1	286	broad.mit.edu	37	chr8	41572563	41572563	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acccgcaccttcccgtacttGgccgccacgtgcagaggggt	12	16	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:41572563G>T	uc003xok.2	-	15	1716	c.1632C>A	c.(1630-1632)GCC>GCA	p.A544A	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Silent_p.A544A|ANK1_uc003xoj.2_Silent_p.A544A|ANK1_uc003xol.2_Silent_p.A544A|ANK1_uc003xom.2_Silent_p.A577A	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	544	89 kDa domain.|ANK 16.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCCCGTACTTGGCCGCCACGT	0.627													1	0	0.000602214	0.000602	0.000635495	4	55										T	41572563	G	T	41572563	2	4	128	1	0	0	0	0	0	0	0	1	620	1335	47	4		4	ANK1	8	41572563	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4850530	41572563	104791459	138	38177										
CHD7	55636	broad.mit.edu	37	chr8	61767054	61767054	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agctcagctccttcatgaaaGaacatttgccttctcgtttt	6	11	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:61767054G>A	uc003xue.2	+	32	7385	c.6908G>A	c.(6907-6909)AGA>AAA	p.R2303K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2303					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTTCATGAAAGAACATTTGCC	0.443													0	0	0	0.00308	0	8	52										A	61767054	G	A	61767054	3	1	128	1	0	0	0	0	1	0	0	0	3330	942	33	1	7030	1	CHD7	8	61767054	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	20194491	61767054	84596968	139	38178										
DNAJC5B	85479	broad.mit.edu	37	chr8	66963856	66963856	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agctctatacgaaattcttgGtctgcataagggagcatcaa	9	8	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:66963856G>C	uc003xvs.1	+	3	365	c.74G>C	c.(73-75)GGT>GCT	p.G25A	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	25	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			GAAATTCTTGGTCTGCATAAG	0.398													0	0	0	0.003163	0	14	78										C	66963856	G	C	66963856	3	2	128	1	0	0	0	0	1	0	0	0	4651	1261	44	4	76	4	DNAJC5B	8	66963856	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	5196802	66963856	79400166	140	38179										
RAD21	5885	broad.mit.edu	37	chr8	117866648	117866648	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggctctaattgtcttgctatCcaactctttgacactgtcaa	6	11	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:117866648C>G	uc003yod.2	-	9	1285	c.997G>C	c.(997-999)GAT>CAT	p.D333H		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	333	Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					GTCTTGCTATCCAACTCTTTG	0.378													0	0	0	0.010771	0	41	88										G	117866648	C	G	117866648	3	3	128	1	0	0	0	0	1	0	0	0	12981	855	30	1	922	1	RAD21	8	117866648	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	50902792	117866648	28497374	141	38180										
TAF2	6873	broad.mit.edu	37	chr8	120790295	120790295	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcattgtacttgattaagtcTaaaataaatgttaagacttc	5	5	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:120790295T>C	uc003you.2	-	18	2598	c.2328A>G	c.(2326-2328)TTA>TTG	p.L776L		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	776					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TGATTAAGTCTAAAATAAATG	0.264													0	0	0	0.000602	0	5	20										C	120790295	T	C	120790295	2	2	128	1	0	0	0	0	0	0	0	1	15521	1519	53	5		5	TAF2	8	120790295	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	2923647	120790295	25573727	142	38181										
MTSS1	9788	broad.mit.edu	37	chr8	125577982	125577982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgaccagctgtaatcagaacCtttcaagtccagaatcacct	6	13	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:125577982C>T	uc003yrk.2	-	9	1279	c.745G>A	c.(745-747)GGT>AGT	p.G249S	NDUFB9_uc011lim.1_Intron|MTSS1_uc011lin.1_5'UTR|MTSS1_uc011lio.1_Missense_Mutation_p.G139S|MTSS1_uc003yri.2_Missense_Mutation_p.G49S|MTSS1_uc003yrj.2_Missense_Mutation_p.G249S|MTSS1_uc003yrl.2_Missense_Mutation_p.G253S	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	249	IMD.|Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TAATCAGAACCTTTCAAGTCC	0.542													0	0	0	0.004672	0	3	31										T	125577982	C	T	125577982	3	4	128	1	0	0	0	0	1	0	0	0	9962	681	24	2	1546	2	MTSS1	8	125577982	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	4787687	125577982	20786040	143	38182										
MYC	4609	broad.mit.edu	37	chr8	128750529	128750529	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgcccctcaacgttagcttCaccaacaggaactatgacct	6	14	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:128750529C>A	uc003ysh.1	+	3	534	c.21C>A	c.(19-21)TTC>TTA	p.F7L	MYC_uc003ysi.2_Missense_Mutation_p.F22L	NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	7				SF -> TI (in Ref. 5; no nucleotide entry).	branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		ACGTTAGCTTCACCAACAGGA	0.587		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.08312e-15	0.009535	1.29651e-15	29	61										A	128750529	C	A	128750529	3	1	128	1	0	0	0	0	1	0	0	0	10016	825	29	3	72	3	MYC	8	128750529	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3172547	128750529	17613493	144	38183										
TG	7038	broad.mit.edu	37	chr8	133948082	133948082	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagtgaggagccatggtcaaGattctccagctgtgtatttg	12	7	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:133948082G>A	uc003ytw.2	+	25	5055	c.5014G>A	c.(5014-5016)GAT>AAT	p.D1672N	TG_uc010mdw.2_Missense_Mutation_p.D431N|TG_uc011ljb.1_Missense_Mutation_p.D105N	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1672	Type IIIA.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCATGGTCAAGATTCTCCAGC	0.527													0	0	0	0.00308	0	8	34										A	133948082	G	A	133948082	3	1	128	1	0	0	0	0	1	0	0	0	15810	942	33	1	5112	1	TG	8	133948082	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	5197553	133948082	12415940	145	38184										
ST3GAL1	6482	broad.mit.edu	37	chr8	134475669	134475669	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccactcaccttatcctgtttCactctgatctttgcaggaac	5	14	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:134475669C>T	uc003yuk.2	-	8	1546	c.717G>A	c.(715-717)GTG>GTA	p.V239V	ST3GAL1_uc003yum.2_Silent_p.V239V	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	239	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			TATCCTGTTTCACTCTGATCT	0.547													0	0	0	0.009096	0	3	17										T	134475669	C	T	134475669	2	4	128	1	0	0	0	0	0	0	0	1	15213	813	29	1		1	ST3GAL1	8	134475669	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	527587	134475669	11888353	146	38185										
CPSF1	29894	broad.mit.edu	37	chr8	145624759	145624759	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcctgcggcaccgacttaccCgcagctgcacacagagagcc	10	17	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr8:145624759C>T	uc003zcj.2	-	14	1374	c.1299G>A	c.(1297-1299)GCG>GCA	p.A433A		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	433					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCGACTTACCCGCAGCTGCAC	0.657													0	0	0	0.001984	0	7	22										T	145624759	C	T	145624759	2	4	128	1	0	0	0	0	0	0	0	1	3824	639	23	2		2	CPSF1	8	145624759	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	11149090	145624759	739263	147	38186										
CDC37L1	55664	broad.mit.edu	37	chr9	4679834	4679834	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccgagggtgaggctgaggaaGagagtgacttcgacgtgttc	17	7	0	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:4679834G>C	uc003zio.2	+	1	277	c.67G>C	c.(67-69)GAG>CAG	p.E23Q		NM_017913	NP_060383	Q7L3B6	CD37L_HUMAN	cell division cycle 37 homolog (S.	23	Self-association.					cytoplasm					0	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		GGCTGAGGAAGAGAGTGACTT	0.697											OREG0019085	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	40										C	4679834	G	C	4679834	3	2	128	1	0	0	0	0	1	0	0	0	3069	943	33	1	69	1	CDC37L1	9	4679834	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		4679834	136533597	148	38187										
TEK	7010	broad.mit.edu	37	chr9	27197331	27197331	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggactccctcctccaagagGtctaaatctcctgcctaaaa	6	14	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:27197331G>C	uc003zqi.3	+	12	2085	c.1643G>C	c.(1642-1644)GGT>GCT	p.G548A	TEK_uc011lno.1_Missense_Mutation_p.G505A|TEK_uc011lnp.1_Missense_Mutation_p.G401A|TEK_uc003zqj.1_Missense_Mutation_p.G482A	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	548	Extracellular (Potential).|Fibronectin type-III 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		CCTCCAAGAGGTCTAAATCTC	0.318													0	0	0	0.00308	0	8	72										C	27197331	G	C	27197331	3	2	128	1	0	0	0	0	1	0	0	0	15748	1261	44	4	1689	4	TEK	9	27197331	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	22517497	27197331	114016100	149	38188										
CCL27	10850	broad.mit.edu	37	chr9	34662358	34662358	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcctcagtagcttgtctgaGagtggctttcggtagagctg	13	8	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:34662358G>C	uc003zvm.1	-	2	185	c.126C>G	c.(124-126)CTC>CTG	p.L42L		NM_006664	NP_006655	Q9Y4X3	CCL27_HUMAN	small inducible cytokine A27 precursor	42					cell-cell signaling|chemotaxis|immune response	extracellular space	chemokine activity				0	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		GCTTGTCTGAGAGTGGCTTTC	0.567													0	0	0	0.008291	0	9	27										C	34662358	G	C	34662358	2	2	128	1	0	0	0	0	0	0	0	1	2899	929	33	1		1	CCL27	9	34662358	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	7465027	34662358	106551073	150	38189										
UNC13B	10497	broad.mit.edu	37	chr9	35396570	35396570	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tacgtgcgggatctgcctgtCctccaggggcaggtgcctga	15	12	1	1	rs150684985		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:35396570C>T	uc003zwq.2	+	26	3451	c.3159C>T	c.(3157-3159)GTC>GTT	p.V1053V	UNC13B_uc003zwr.2_Silent_p.V1053V	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1053	MHD1.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity	p.V1053V(1)		ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			ATCTGCCTGTCCTCCAGGGGC	0.547													0	0	0	0.014323	0	23	51										T	35396570	C	T	35396570	2	4	128	1	0	0	0	0	0	0	0	1	16982	842	30	1		1	UNC13B	9	35396570	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	734212	35396570	105816861	151	38190										
GDA	9615	broad.mit.edu	37	chr9	74856157	74856157	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttttaattaataaggtaaatGagaaaagcctcaccctcaaa	5	7	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:74856157G>A	uc004aiq.2	+	11	1261	c.1078G>A	c.(1078-1080)GAG>AAG	p.E360K	GDA_uc011lse.1_Missense_Mutation_p.E286K|GDA_uc011lsf.1_Missense_Mutation_p.E286K|GDA_uc004air.2_Missense_Mutation_p.E360K|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Missense_Mutation_p.E282K	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	360					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		TAAGGTAAATGAGAAAAGCCT	0.403													0	0	0	0.001168	0	6	55										A	74856157	G	A	74856157	3	1	128	1	0	0	0	0	1	0	0	0	6306	1291	45	1	1120	1	GDA	9	74856157	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	39459587	74856157	66357274	152	38191										
VPS13A	23230	broad.mit.edu	37	chr9	79974283	79974283	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acagatgtcagtattgtcatGagatctgcaggacattccca	9	9	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:79974283G>C	uc004akr.2	+	58	8330	c.8070G>C	c.(8068-8070)ATG>ATC	p.M2690I	VPS13A_uc004akp.3_Missense_Mutation_p.M2690I|VPS13A_uc004akq.3_Missense_Mutation_p.M2690I|VPS13A_uc004aks.2_Missense_Mutation_p.M2651I	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2690					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GTATTGTCATGAGATCTGCAG	0.308													0	0	0	0.009096	0	4	21										C	79974283	G	C	79974283	3	2	128	1	0	0	0	0	1	0	0	0	17186	1290	45	1	8300	1	VPS13A	9	79974283	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	5118126	79974283	61239148	153	38192										
ZCCHC6	79670	broad.mit.edu	37	chr9	88967883	88967883	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtagattgggtttttaaatgCatatggattgctggaaacag	12	3	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:88967883C>T	uc004aoq.2	-	2	447	c.232G>A	c.(232-234)GCA>ACA	p.A78T	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.A78T|ZCCHC6_uc004aou.2_Missense_Mutation_p.A78T|ZCCHC6_uc004aov.2_Missense_Mutation_p.A78T|ZCCHC6_uc004aow.2_Missense_Mutation_p.A78T|ZCCHC6_uc010mqf.1_Missense_Mutation_p.A78T	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	78					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TTTTTAAATGCATATGGATTG	0.418													0	0	0	0.003163	0	15	144										T	88967883	C	T	88967883	3	4	128	1	0	0	0	0	1	0	0	0	17589	710	25	2	4359	2	ZCCHC6	9	88967883	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	8993600	88967883	52245548	154	38193										
TDRD7	23424	broad.mit.edu	37	chr9	100245529	100245529	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccttggcaggagatacataaGttggaagttctgatggaaga	13	5	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:100245529G>A	uc004axj.2	+	15	3036	c.2811G>A	c.(2809-2811)AAG>AAA	p.K937K	TDRD7_uc011lux.1_Silent_p.K863K|TDRD7_uc010msp.1_Silent_p.K189K|TDRD7_uc011luy.1_Silent_p.K257K	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	937	Interacts with CDK17 (By similarity).|Interacts with CABLES1 (By similarity).				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				AGATACATAAGTTGGAAGTTC	0.478													0	0	0	0.001168	0	6	75										A	100245529	G	A	100245529	2	1	128	1	0	0	0	0	0	0	0	1	15732	1020	36	2		2	TDRD7	9	100245529	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	11277646	100245529	40967902	155	38194										
PAPPA	5069	broad.mit.edu	37	chr9	118950282	118950282	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	catcagcaagattggggatgAgaactgtgaccccgagtgca	13	9	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:118950282A>G	uc004bjn.2	+	2	1646	c.1265A>G	c.(1264-1266)GAG>GGG	p.E422G	PAPPA_uc011lxp.1_Missense_Mutation_p.E215G|PAPPA_uc011lxq.1_Missense_Mutation_p.E215G	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	422	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ATTGGGGATGAGAACTGTGAC	0.627													0	0	0	0.007413	0	19	36										G	118950282	A	G	118950282	3	3	128	1	0	0	0	0	1	0	0	0	11432	304	11	5	1271	5	PAPPA	9	118950282	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	18704753	118950282	22263149	156	38195										
STRBP	55342	broad.mit.edu	37	chr9	125898437	125898437	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttatttggacctgcgcctctGaatttctgtccatctacttc	6	12	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:125898437G>C	uc004bns.2	-	16	2086	c.1656C>G	c.(1654-1656)TTC>TTG	p.F552L	STRBP_uc004bnt.2_Missense_Mutation_p.F370L|STRBP_uc004bnu.2_Missense_Mutation_p.F538L|STRBP_uc004bnv.2_Missense_Mutation_p.F552L|STRBP_uc004bnr.2_Missense_Mutation_p.F111L	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	552	DRBM 2.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						CTGCGCCTCTGAATTTCTGTC	0.393													0	0	0	0.006214	0	10	71										C	125898437	G	C	125898437	3	2	128	1	0	0	0	0	1	0	0	0	15326	1281	45	1	378	1	STRBP	9	125898437	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	6948155	125898437	15314994	157	38196										
SH2D3C	10044	broad.mit.edu	37	chr9	130507349	130507349	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggcaatgctgtggcagaagGggctgcaggggcggcatgga	20	7	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:130507349G>T	uc004bsc.2	-	7	1436	c.1294C>A	c.(1294-1296)CCT>ACT	p.P432T	SH2D3C_uc010mxo.2_Missense_Mutation_p.P272T|SH2D3C_uc004bry.2_Missense_Mutation_p.P274T|SH2D3C_uc004brz.3_Missense_Mutation_p.P78T|SH2D3C_uc011mak.1_Missense_Mutation_p.P78T|SH2D3C_uc004bsa.2_Missense_Mutation_p.P275T|SH2D3C_uc004bsb.2_Missense_Mutation_p.P364T	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	432					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GTGGCAGAAGGGGCTGCAGGG	0.627													1	0	3.27435e-08	0.00245	3.71959e-08	15	27										T	130507349	G	T	130507349	3	4	128	1	0	0	0	0	1	0	0	0	14234	1232	43	4	1312	4	SH2D3C	9	130507349	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4608912	130507349	10706082	158	38197										
PKN3	29941	broad.mit.edu	37	chr9	131475651	131475651	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcctgggaccagacctttgtCatcccactggagcgagtaag	11	12	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr9:131475651C>T	uc004bvw.2	+	8	1470	c.1077C>T	c.(1075-1077)GTC>GTT	p.V359V	PKN3_uc010myh.2_Silent_p.V359V|PKN3_uc011mbk.1_5'UTR	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	359					signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						AGACCTTTGTCATCCCACTGG	0.652													0	0	0	0.004482	0	8	31										T	131475651	C	T	131475651	2	4	128	1	0	0	0	0	0	0	0	1	11981	813	29	1		1	PKN3	9	131475651	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	968302	131475651	9737780	159	38198										
ECHDC3	79746	broad.mit.edu	37	chr10	11789413	11789413	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcaatgctgaagtctctccAaagtgacattcttcatgacg	8	10	3	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:11789413A>C	uc001ikw.3	+	2	456	c.236A>C	c.(235-237)CAA>CCA	p.Q79P	ECHDC3_uc009xix.2_5'UTR	NM_024693	NP_078969	Q96DC8	ECHD3_HUMAN	enoyl Coenzyme A hydratase domain containing 3	79						mitochondrion	catalytic activity				0						AAGTCTCTCCAAAGTGACATT	0.438													0	0	0	0.014323	0	17	99										C	11789413	A	C	11789413	3	2	128	1	0	0	0	0	1	0	0	0	4895	130	5	5	242	5	ECHDC3	10	11789413	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08		11789413	123745334	160	38199										
ANKRD26	22852	broad.mit.edu	37	chr10	27389109	27389109	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcgctggcagctttgtggatCttgccgagatctcggtctcg	14	11	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:27389109C>G	uc001ith.2	-	1	319	c.147G>C	c.(145-147)AAG>AAC	p.K49N	ANKRD26_uc009xku.1_Missense_Mutation_p.K49N	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	49	ANK 1.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CTTTGTGGATCTTGCCGAGAT	0.622													0	0	0	0.013726	0	32	76										G	27389109	C	G	27389109	3	3	128	1	0	0	0	0	1	0	0	0	654	912	32	1	5121	1	ANKRD26	10	27389109	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	15599696	27389109	108145638	161	38200										
ZNF37A	7587	broad.mit.edu	37	chr10	38407718	38407718	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tacatcagagaatacacttgGggagaaaccctataaatgta	8	7	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:38407718G>C	uc001izk.2	+	8	2458	c.1639G>C	c.(1639-1641)GGG>CGG	p.G547R	ZNF37A_uc001izl.2_Missense_Mutation_p.G547R|ZNF37A_uc001izm.2_Missense_Mutation_p.G547R	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	547						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AATACACTTGGGGAGAAACCC	0.363													0	0	0	0.004482	0	9	38										C	38407718	G	C	38407718	3	2	128	1	0	0	0	0	1	0	0	0	17869	1232	43	4	1653	4	ZNF37A	10	38407718	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	11018609	38407718	97127029	162	38201										
CHAT	1103	broad.mit.edu	37	chr10	50854654	50854654	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agcgacacccacagggcactCcagctccttcacggcggagg	12	16	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:50854654C>G	uc001jhz.2	+	8	1368	c.1215C>G	c.(1213-1215)CTC>CTG	p.L405L	CHAT_uc001jhv.1_Silent_p.L287L|CHAT_uc001jhx.1_Silent_p.L287L|CHAT_uc001jhy.1_Silent_p.L287L|CHAT_uc001jia.2_Silent_p.L287L|CHAT_uc010qgs.1_Silent_p.L287L	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	405					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	ACAGGGCACTCCAGCTCCTTC	0.637													0	0	0	0.001855	0	14	43										G	50854654	C	G	50854654	2	3	128	1	0	0	0	0	0	0	0	1	3313	842	30	1		1	CHAT	10	50854654	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	12446936	50854654	84680093	163	38202										
PRKG1	5592	broad.mit.edu	37	chr10	54048534	54048534	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaaacctataacatcatattGagggggattgacatgataga	9	5	1	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:54048534G>C	uc001jjm.2	+	15	1907	c.1713G>C	c.(1711-1713)TTG>TTC	p.L571F	PRKG1_uc001jjo.2_Missense_Mutation_p.L586F|PRKG1_uc009xow.1_Missense_Mutation_p.L289F|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	571	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		ACATCATATTGAGGGGGATTG	0.343													0	0	0	0.000602	0	5	64										C	54048534	G	C	54048534	3	2	128	1	0	0	0	0	1	0	0	0	12522	1281	45	1	2086	1	PRKG1	10	54048534	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3193880	54048534	81486213	164	38203										
PCDH15	65217	broad.mit.edu	37	chr10	56138648	56138648	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttaaagaaagttctatggtgGggtctggtcctccagcagtc	12	8	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:56138648G>C	uc001jju.1	-	4	607	c.212C>G	c.(211-213)CCC>CGC	p.P71R	PCDH15_uc010qhq.1_Missense_Mutation_p.P76R|PCDH15_uc010qhr.1_Missense_Mutation_p.P71R|PCDH15_uc010qhs.1_Missense_Mutation_p.P76R|PCDH15_uc010qht.1_Missense_Mutation_p.P71R|PCDH15_uc010qhu.1_Missense_Mutation_p.P71R|PCDH15_uc001jjv.1_Missense_Mutation_p.P49R|PCDH15_uc010qhv.1_Missense_Mutation_p.P71R|PCDH15_uc010qhw.1_Missense_Mutation_p.P71R|PCDH15_uc010qhx.1_Missense_Mutation_p.P71R|PCDH15_uc010qhy.1_Missense_Mutation_p.P76R|PCDH15_uc010qhz.1_Missense_Mutation_p.P71R|PCDH15_uc010qia.1_Missense_Mutation_p.P49R|PCDH15_uc010qib.1_Missense_Mutation_p.P49R|PCDH15_uc001jjw.2_Missense_Mutation_p.P71R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	71	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCTATGGTGGGGTCTGGTCC	0.423										HNSCC(58;0.16)			0	0	0	0.00308	0	8	149										C	56138648	G	C	56138648	3	2	128	1	0	0	0	0	1	0	0	0	11511	1232	43	4	7419	4	PCDH15	10	56138648	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2090114	56138648	79396099	165	38204										
ANK3	288	broad.mit.edu	37	chr10	61832871	61832871	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acgaaaaaactgtgacacttCagtcagtttttcttcagcct	6	10	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:61832871C>T	uc001jky.2	-	37	7960	c.7768G>A	c.(7768-7770)GAA>AAA	p.E2590K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2590					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TGTGACACTTCAGTCAGTTTT	0.418													0	0	0	0.004656	0	28	81										T	61832871	C	T	61832871	3	4	128	1	0	0	0	0	1	0	0	0	622	835	29	1	5706	1	ANK3	10	61832871	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	5694223	61832871	73701876	166	38205										
TET1	80312	broad.mit.edu	37	chr10	70405499	70405499	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagtcacaaattcattatctCtttttataccaaaatcaaat	1	8	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:70405499C>G	uc001jok.3	+	4	3518	c.3013C>G	c.(3013-3015)CTT>GTT	p.L1005V		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1005					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TTCATTATCTCTTTTTATACC	0.338													0	0	0	0.001168	0	6	62										G	70405499	C	G	70405499	3	3	128	1	0	0	0	0	1	0	0	0	15766	913	32	1	3023	1	TET1	10	70405499	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	8572628	70405499	65129248	167	38206										
GRID1	2894	broad.mit.edu	37	chr10	88123752	88123752	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gatgaccttgatggagtaggTgatcttctcgctctgcagga	13	8	3	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:88123752T>C	uc001kdl.1	-	2	282	c.181A>G	c.(181-183)ACC>GCC	p.T61A	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	61	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ATGGAGTAGGTGATCTTCTCG	0.602										Multiple Myeloma(13;0.14)			0	0	0	0.00308	0	8	37										C	88123752	T	C	88123752	3	2	128	1	0	0	0	0	1	0	0	0	6771	1696	59	5	2908	5	GRID1	10	88123752	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	17718253	88123752	47410995	168	38207										
ZNF518A	9849	broad.mit.edu	37	chr10	97919613	97919613	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gacaacgtaccatctaatcaGattataggaggagagcagaa	10	7	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr10:97919613G>C	uc001klp.2	+	6	4391	c.3534G>C	c.(3532-3534)CAG>CAC	p.Q1178H	ZNF518A_uc001klo.1_Missense_Mutation_p.Q648H|ZNF518A_uc001klq.2_Missense_Mutation_p.Q1178H|ZNF518A_uc001klr.2_Missense_Mutation_p.Q1178H	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CATCTAATCAGATTATAGGAG	0.373													0	0	0	0.010729	0	11	54										C	97919613	G	C	97919613	3	2	128	1	0	0	0	0	1	0	0	0	17959	933	33	1	3536	1	ZNF518A	10	97919613	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9795861	97919613	37615134	169	38208										
MUC5B	727897	broad.mit.edu	37	chr11	1151641	1151641	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cacacaatgagtgttggccgGaggaagctggccctgctctg	14	11	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:1151641G>C	uc009ycr.1	+	2	141	c.15G>C	c.(13-15)CGG>CGC	p.R5R		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:Variant_position_missing_in_Q9HC84_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGTTGGCCGGAGGAAGCTGG	0.662													0	0	0	0.004672	0	3	3										C	1151641	G	C	1151641	2	2	128	1	0	0	0	0	0	0	0	1	9979	1189	41	1		1	MUC5B	11	1151641	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		1151641	133854875	170	38209										
PLEKHA7	144100	broad.mit.edu	37	chr11	16892712	16892712	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcacaggatgcctgaatgctGtggtctgctggttatggcta	13	8	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:16892712G>C	uc001mmo.2	-	4	254	c.239C>G	c.(238-240)ACA>AGA	p.T80R	PLEKHA7_uc010rcu.1_Missense_Mutation_p.T80R	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	80	WW 2.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CCTGAATGCTGTGGTCTGCTG	0.428													0	0	0	0.001984	0	6	32										C	16892712	G	C	16892712	3	2	128	1	0	0	0	0	1	0	0	0	12061	1377	48	4	3206	4	PLEKHA7	11	16892712	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	15741071	16892712	118113804	171	38210										
WT1	7490	broad.mit.edu	37	chr11	32456366	32456366	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggaccgaagggcccgtagcGacaggctccggctgtgccag	16	13	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:32456366G>A	uc001mtn.1	-	1	722	c.526C>T	c.(526-528)CGC>TGC	p.R176C	WT1_uc001mto.1_Missense_Mutation_p.R176C|WT1_uc001mtp.1_Missense_Mutation_p.R176C|WT1_uc001mtq.1_Missense_Mutation_p.R176C|WT1_uc009yjs.1_RNA|WIT1_uc010rec.1_5'Flank|WIT1_uc010red.1_5'Flank|WIT1_uc010ree.1_5'Flank	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	108					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GGCCCGTAGCGACAGGCTCCG	0.692			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				0	0	0	0.001168	0	6	18										A	32456366	G	A	32456366	3	1	128	1	0	0	0	0	1	0	0	0	17405	1058	37	1	1067	1	WT1	11	32456366	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	15563654	32456366	102550150	172	38211										
CKAP5	9793	broad.mit.edu	37	chr11	46771875	46771875	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctctccatctcaatcacccGaaggcctctttcgacatagc	5	17	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:46771875G>C	uc001ndi.1	-	42	5763	c.5653C>G	c.(5653-5655)CGG>GGG	p.R1885G	CKAP5_uc009ylg.1_Missense_Mutation_p.R1778G|CKAP5_uc001ndj.1_Missense_Mutation_p.R1825G|CKAP5_uc001ndh.1_Missense_Mutation_p.R814G	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1885					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TCAATCACCCGAAGGCCTCTT	0.413													0	0	0	0.006122	0	18	69										C	46771875	G	C	46771875	3	2	128	1	0	0	0	0	1	0	0	0	3445	1057	37	1	457	1	CKAP5	11	46771875	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	14315509	46771875	88234641	173	38212										
P2RX3	5024	broad.mit.edu	37	chr11	57118338	57118338	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cccggctcgacagcgtttctGagaaaagcagcgtgtcccca	11	14	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:57118338G>A	uc001nju.2	+	8	884	c.808G>A	c.(808-810)GAG>AAG	p.E270K		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	270	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CAGCGTTTCTGAGAAAAGCAG	0.552													0	0	0	0.010729	0	11	36										A	57118338	G	A	57118338	3	1	128	1	0	0	0	0	1	0	0	0	11341	1291	45	1	838	1	P2RX3	11	57118338	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	10346463	57118338	77888178	174	38213										
C11orf9	745	broad.mit.edu	37	chr11	61543557	61543557	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgaaccagtccattaacatCgagcagtcccagtcagaccg	8	14	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:61543557C>T	uc001nsc.1	+	9	1437	c.1341C>T	c.(1339-1341)ATC>ATT	p.I447I	C11orf9_uc001nse.1_Silent_p.I438I|C11orf9_uc010rll.1_5'Flank	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	447	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CCATTAACATCGAGCAGTCCC	0.622													0	0	0	0.000602	0	5	64										T	61543557	C	T	61543557	2	4	128	1	0	0	0	0	0	0	0	1	1671	874	31	1		1	C11orf9	11	61543557	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	4425219	61543557	73462959	175	38214										
AHNAK	79026	broad.mit.edu	37	chr11	62287326	62287326	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gggtcctttcaaatccaggtCaacatcaggtatggagatct	10	9	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:62287326C>A	uc001ntl.2	-	5	14863	c.14563G>T	c.(14563-14565)GAC>TAC	p.D4855Y	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4855					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAATCCAGGTCAACATCAGGT	0.433													1	0	2.89027e-11	0.014323	3.39882e-11	24	91										A	62287326	C	A	62287326	3	1	128	1	0	0	0	0	1	0	0	0	414	826	29	3	3229	3	AHNAK	11	62287326	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	743769	62287326	72719190	176	38215										
VEGFB	7423	broad.mit.edu	37	chr11	64004936	64004936	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccagccccgttctgttccggGctgggactctgcccccggag	13	17	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:64004936G>A	uc001nyw.2	+	6	495	c.455G>A	c.(454-456)GGC>GAC	p.G152D	VEGFB_uc001nyx.2_Intron	NM_003377	NP_003368	P49765	VEGFB_HUMAN	vascular endothelial growth factor B precursor	152					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0						TCTGTTCCGGGCTGGGACTCT	0.682													0	0	0	0.000602	0	5	24										A	64004936	G	A	64004936	3	1	128	1	0	0	0	0	1	0	0	0	17148	1203	42	2	477	2	VEGFB	11	64004936	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1717610	64004936	71001580	177	38216										
FAU	2197	broad.mit.edu	37	chr11	64889260	64889260	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcacctcgaaggtgtgtagcTcctgggcgcggacaaagagc	14	11	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:64889260T>A	uc001ocx.2	-	2	133	c.26A>T	c.(25-27)GAG>GTG	p.E9V	FAU_uc001ocy.1_Missense_Mutation_p.E9V|MRPL49_uc001ocz.1_5'Flank|MRPL49_uc001oda.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	ubiquitin-like protein fubi and ribosomal	9											0						GGTGTGTAGCTCCTGGGCGCG	0.527													0	0	0	0.000602	0	5	42										A	64889260	T	A	64889260	3	1	128	1	0	0	0	0	1	0	0	0	5694	1551	54	5	391	5	FAU	11	64889260	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	884324	64889260	70117256	178	38217										
ACY3	91703	broad.mit.edu	37	chr11	67412565	67412565	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	actgtggccaccagggtcctCatccttgagaaaatgtcagc	10	12	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:67412565C>G	uc001omq.2	-	6	756	c.585G>C	c.(583-585)ATG>ATC	p.M195I		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	195					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	CCAGGGTCCTCATCCTTGAGA	0.612													0	0	0	0.012213	0	32	98										G	67412565	C	G	67412565	3	3	128	1	0	0	0	0	1	0	0	0	227	826	29	1	386	1	ACY3	11	67412565	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2523305	67412565	67593951	179	38218										
ACY3	91703	broad.mit.edu	37	chr11	67412598	67412598	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgtcagcccgcagcacaccCtgtggctgggggcccagctc	13	16	1	0	rs142720670		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:67412598C>A	uc001omq.2	-	6	723	c.552G>T	c.(550-552)CAG>CAT	p.Q184H		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	184					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	GCAGCACACCCTGTGGCTGGG	0.602													1	0	1.10513e-12	0.014323	1.30725e-12	24	82										A	67412598	C	A	67412598	3	1	128	1	0	0	0	0	1	0	0	0	227	680	24	4	419	4	ACY3	11	67412598	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	33	67412598	67593918	180	38219										
IGHMBP2	3508	broad.mit.edu	37	chr11	68682376	68682376	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcagcggattctgcgcctggGacaccctgcccgcctcctgg	13	17	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:68682376G>A	uc001ook.1	+	6	899	c.797G>A	c.(796-798)GGA>GAA	p.G266E	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	266	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTGCGCCTGGGACACCCTGCC	0.612													0	0	0	0.008291	0	10	64										A	68682376	G	A	68682376	3	1	128	1	0	0	0	0	1	0	0	0	7591	1174	41	1	819	1	IGHMBP2	11	68682376	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1269778	68682376	66324140	181	38220										
MED17	9440	broad.mit.edu	37	chr11	93540715	93540715	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcaattgaatattggagttGagcagattcgagttgtacat	11	4	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:93540715G>C	uc001pem.3	+	10	1773	c.1498G>C	c.(1498-1500)GAG>CAG	p.E500Q		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	500					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TATTGGAGTTGAGCAGATTCG	0.338													0	0	0	0.014323	0	21	53										C	93540715	G	C	93540715	3	2	128	1	0	0	0	0	1	0	0	0	9435	1291	45	1	1536	1	MED17	11	93540715	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	24858339	93540715	41465801	182	38221										
MAML2	84441	broad.mit.edu	37	chr11	95712801	95712801	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttgtgaattaccaacagatcCagctccaaaagtggctacat	7	10	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:95712801C>A	uc001pfw.1	-	5	4067	c.2782G>T	c.(2782-2784)GGA>TGA	p.G928*		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	928					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCAACAGATCCAGCTCCAAAA	0.413			T	MECT1|CRTC3	salivary gland mucoepidermoid								1	0	5.50884e-06	0.013537	6.03564e-06	12	62										A	95712801	C	A	95712801	4	1	128	1	0	0	0	0	0	1	0	0	9206	603	21	4	692	4	MAML2	11	95712801	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2172086	95712801	39293715	183	38222										
ATM	472	broad.mit.edu	37	chr11	108192066	108192066	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gatgtgtaagcgcagccttgAgtctgtgtattcgctctatc	11	9	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:108192066A>G	uc001pkb.1	+	45	6876	c.6491A>G	c.(6490-6492)GAG>GGG	p.E2164G	ATM_uc009yxr.1_Missense_Mutation_p.E2164G|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E816G|ATM_uc001pkg.1_Missense_Mutation_p.E521G	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2164	FAT.		E -> K (in T-prolymphocytic leukemia).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.E2164K(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CGCAGCCTTGAGTCTGTGTAT	0.413			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.006214	0	10	78										G	108192066	A	G	108192066	3	3	128	1	0	0	0	0	1	0	0	0	1109	304	11	5	6665	5	ATM	11	108192066	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	12479265	108192066	26814450	184	38223										
DSCAML1	57453	broad.mit.edu	37	chr11	117342611	117342611	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctcagtgctgatggtgagctCcttgcttggttcactgcggc	13	11	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:117342611C>G	uc001prh.1	-	15	3108	c.3106G>C	c.(3106-3108)GAG>CAG	p.E1036Q		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	976	Extracellular (Potential).|Fibronectin type-III 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ATGGTGAGCTCCTTGCTTGGT	0.592													0	0	0	0.012319	0	21	32										G	117342611	C	G	117342611	3	3	128	1	0	0	0	0	1	0	0	0	4769	864	30	1	3311	1	DSCAML1	11	117342611	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	9150545	117342611	17663905	185	38224										
CBL	867	broad.mit.edu	37	chr11	119142469	119142469	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aacctaaccaaactgtccctCatcttcagccacatgctggc	5	16	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:119142469C>T	uc001pwe.2	+	3	606	c.468C>T	c.(466-468)CTC>CTT	p.L156L		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	156	Cbl-PTB.|4H.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		AACTGTCCCTCATCTTCAGCC	0.368									CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				0	0	0	0.010818	0	33	49										T	119142469	C	T	119142469	2	4	128	1	0	0	0	0	0	0	0	1	2700	813	29	1		1	CBL	11	119142469	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1799858	119142469	15864047	186	38225										
MFRP	83552	broad.mit.edu	37	chr11	119216324	119216324	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgaagaagccccttgggccAgagaggaggcctccacaggc	14	13	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:119216324A>C	uc001pwj.2	-	5	607	c.447T>G	c.(445-447)TCT>TCG	p.S149S	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Silent_p.S149S	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCCTTGGGCCAGAGAGGAGGC	0.572													0	0	0	0.004482	0	8	45										C	119216324	A	C	119216324	2	2	128	1	0	0	0	0	0	0	0	1	9526	175	7	5		5	MFRP	11	119216324	Silent	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	73855	119216324	15790192	187	38226										
OR8B4	283162	broad.mit.edu	37	chr11	124294104	124294104	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggaatacagaggatgttggAgagtatcaaagcgtaagaga	14	3	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:124294104A>G	uc010sak.1	-	1	664	c.664T>C	c.(664-666)TCC>CCC	p.S222P		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AGGATGTTGGAGAGTATCAAA	0.468													0	0	0	0.00245	0	14	29										G	124294104	A	G	124294104	3	3	128	1	0	0	0	0	1	0	0	0	11229	304	11	5	267	5	OR8B4	11	124294104	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	5077780	124294104	10712412	188	38227										
VSIG2	23584	broad.mit.edu	37	chr11	124621381	124621381	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccactccagggcgaagctgtCtcccaccgacgtgctgtagg	12	15	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:124621381C>A	uc001qas.2	-	2	233	c.157G>T	c.(157-159)GAC>TAC	p.D53Y	VSIG2_uc001qat.2_Missense_Mutation_p.D53Y	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	53	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GCGAAGCTGTCTCCCACCGAC	0.637													1	0	0.00448238	0.004482	0.00466866	8	52										A	124621381	C	A	124621381	3	1	128	1	0	0	0	0	1	0	0	0	17221	913	32	3	850	3	VSIG2	11	124621381	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	327277	124621381	10385135	189	38228										
ADAMTS8	11095	broad.mit.edu	37	chr11	130286913	130286925	+	Frame_Shift_Del	DEL	TGGTCCCGATGTC	TGGTCCCGATGTC	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcttttgttggggtcacaaaTggtcccgatgtctgccacac							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr11:130286913_130286925delTGGTCCCGATGTC	uc001qgg.3	-	3	1364_1376	c.1006_1018delGACATCGGGACCA	c.(1006-1020)GACATCGGGACCATTfs	p.D336fs		NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	336_340	Peptidase M12B.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGGTCACAAATGGTCCCGATGTCTGCCACACCC	0.601																		8	136	---	---								-	130286925	TGGTCCCGATGTC	-	130286913	7	5	128	1	0	1	0	1	0	0	0	0	272	1464	51	0	1679	0	ADAMTS8	11	130286913	Frame_Shift_Del	DEL	TGGTCCCGATGTC	TCGA-K4-A3WS-01A-11D-A22Z-08	5665532	130286913	4719603	190	38229										
AKAP3	10566	broad.mit.edu	37	chr12	4735736	4735736	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctcagaggcagctacccattGaaggacggcttggagttgct	13	10	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:4735736G>A	uc001qnb.3	-	4	2561	c.2332C>T	c.(2332-2334)CAA>TAA	p.Q778*		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	778					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						GCTACCCATTGAAGGACGGCT	0.493													0	0	0	0.000602	0	5	71										A	4735736	G	A	4735736	4	1	128	1	0	0	0	0	0	1	0	0	452	1299	45	1	237	1	AKAP3	12	4735736	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		4735736	129116159	191	38230										
CHD4	1108	broad.mit.edu	37	chr12	6703629	6703629	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccccagatttccttacctccTtgtaaagggaatacaggaag	8	11	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:6703629T>C	uc001qpo.2	-	15	2473	c.2309A>G	c.(2308-2310)AAG>AGG	p.K770R	CHD4_uc001qpn.2_Missense_Mutation_p.K763R|CHD4_uc001qpp.2_Missense_Mutation_p.K767R	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	770	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CCTTACCTCCTTGTAAAGGGA	0.448													0	0	0	0.010729	0	12	47										C	6703629	T	C	6703629	3	2	128	1	0	0	0	0	1	0	0	0	3327	1609	56	5	3533	5	CHD4	12	6703629	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	1967893	6703629	127148266	192	38231										
GYS2	2998	broad.mit.edu	37	chr12	21693375	21693375	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atctccaatccagaagatctGagagcctctcagttctgttc	7	12	4	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:21693375G>A	uc001rfb.2	-	14	2033	c.1778C>T	c.(1777-1779)TCA>TTA	p.S593L		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	593					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						CAGAAGATCTGAGAGCCTCTC	0.403													0	0	0	0.004656	0	26	160										A	21693375	G	A	21693375	3	1	128	1	0	0	0	0	1	0	0	0	6913	1294	45	1	345	1	GYS2	12	21693375	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	14989746	21693375	112158520	193	38232										
IPO8	10526	broad.mit.edu	37	chr12	30833434	30833434	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acctgaacaagtgcataaaaGattttcagaatttgtttctg	7	6	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:30833434G>C	uc001rjd.2	-	5	791	c.621C>G	c.(619-621)ATC>ATG	p.I207M		NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	207					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GTGCATAAAAGATTTTCAGAA	0.289													0	0	0	0.004482	0	9	56										C	30833434	G	C	30833434	3	2	128	1	0	0	0	0	1	0	0	0	7798	932	33	1	2576	1	IPO8	12	30833434	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	9140059	30833434	103018461	194	38233										
ARID2	196528	broad.mit.edu	37	chr12	46243532	46243532	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcgtgttgattctgttcctGatgtatctcctgctccttca	7	11	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:46243532G>C	uc001ros.1	+	14	1885	c.1885G>C	c.(1885-1887)GAT>CAT	p.D629H	ARID2_uc001ror.2_Missense_Mutation_p.D629H|ARID2_uc009zkg.1_Missense_Mutation_p.D85H|ARID2_uc009zkh.1_Missense_Mutation_p.D256H|ARID2_uc001rou.1_5'Flank	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	629					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCTGTTCCTGATGTATCTCC	0.343													0	0	0	0.003271	0	36	158										C	46243532	G	C	46243532	3	2	128	1	0	0	0	0	1	0	0	0	915	1290	45	1	1939	1	ARID2	12	46243532	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	15410098	46243532	87608363	195	38234										
ARID2	196528	broad.mit.edu	37	chr12	46245434	46245434	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaccaggtaaccataacagtTgtgccaaatacgagttttgc	8	9	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:46245434T>C	uc001ros.1	+	15	3528	c.3528T>C	c.(3526-3528)GTT>GTC	p.V1176V	ARID2_uc001ror.2_Silent_p.V1176V|ARID2_uc009zkg.1_Silent_p.V632V|ARID2_uc009zkh.1_Silent_p.V803V|ARID2_uc001rou.1_Silent_p.V510V	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1176					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCATAACAGTTGTGCCAAATA	0.478													0	0	0	0.006214	0	10	76										C	46245434	T	C	46245434	2	2	128	1	0	0	0	0	0	0	0	1	915	1799	63	5		5	ARID2	12	46245434	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	1902	46245434	87606461	196	38235										
ZNF641	121274	broad.mit.edu	37	chr12	48737057	48737057	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgccttctgcatgcactctcTggtggctggccagatgggag	14	11	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:48737057T>C	uc001rrn.1	-	6	1181	c.1016A>G	c.(1015-1017)CAG>CGG	p.Q339R	ZNF641_uc001rro.1_Missense_Mutation_p.Q325R|ZNF641_uc010sls.1_Missense_Mutation_p.Q316R	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	339	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						ATGCACTCTCTGGTGGCTGGC	0.557													0	0	0	0.003954	0	25	81										C	48737057	T	C	48737057	3	2	128	1	0	0	0	0	1	0	0	0	18054	1580	55	5	304	5	ZNF641	12	48737057	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	2491623	48737057	85114838	197	38236										
C12orf54	121273	broad.mit.edu	37	chr12	48879982	48879982	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acatccatagaagagacaatGagaccacaggtgggtaaggt	12	7	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:48879982G>C	uc001rrr.2	+	2	144	c.87G>C	c.(85-87)ATG>ATC	p.M29I	C12orf54_uc009zky.1_RNA	NM_152319	NP_689532	Q6X4T0	CL054_HUMAN	hypothetical protein LOC121273	29											0						AAGAGACAATGAGACCACAGG	0.458													0	0	0	0.001855	0	12	63										C	48879982	G	C	48879982	3	2	128	1	0	0	0	0	1	0	0	0	1699	1290	45	1	93	1	C12orf54	12	48879982	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	142925	48879982	84971913	198	38237										
MLL2	8085	broad.mit.edu	37	chr12	49444981	49444981	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gggggacaggtgtgattcctCaggttggggggacaagcatg	19	6	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:49444981C>G	uc001rta.3	-	10	2485	c.2485G>C	c.(2485-2487)GAG>CAG	p.E829Q		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	829	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTGATTCCTCAGGTTGGGGG	0.632			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.010729	0	11	49										G	49444981	C	G	49444981	3	3	128	1	0	0	0	0	1	0	0	0	9621	835	29	1	14308	1	MLL2	12	49444981	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	564999	49444981	84406914	199	38238										
HIGD1C	613227	broad.mit.edu	37	chr12	51347856	51347856	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctaatcaggaaatctagagaCtccccctttgtccctatagg	7	12	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:51347856C>A	uc010smw.1	+	1	75	c.75C>A	c.(73-75)GAC>GAA	p.D25E		NM_001109619	NP_001103089	A8MV81	HIG1C_HUMAN	HIG1 domain family, member 1C	25	HIG1.|Cytoplasmic (Potential).					integral to membrane					0						AATCTAGAGACTCCCCCTTTG	0.348													1	0	0.00621372	0.006214	0.00642191	9	82										A	51347856	C	A	51347856	3	1	128	1	0	0	0	0	1	0	0	0	7108	564	20	4	77	4	HIGD1C	12	51347856	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1902875	51347856	82504039	200	38239										
ACVR1B	91	broad.mit.edu	37	chr12	52379062	52379062	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtgccatagcagacctgggcCtggctgtccgtcatgatgca	13	12	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:52379062C>G	uc001rzn.2	+	6	1108	c.1066C>G	c.(1066-1068)CTG>GTG	p.L356V	ACVR1B_uc001rzl.2_Missense_Mutation_p.L356V|ACVR1B_uc001rzm.2_Missense_Mutation_p.L356V|ACVR1B_uc010snn.1_Missense_Mutation_p.L397V	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	356	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	AGACCTGGGCCTGGCTGTCCG	0.522													0	0	0	0.00245	0	14	64										G	52379062	C	G	52379062	3	3	128	1	0	0	0	0	1	0	0	0	221	680	24	4	1215	4	ACVR1B	12	52379062	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1031206	52379062	81472833	201	38240										
RARG	5916	broad.mit.edu	37	chr12	53607931	53607931	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcaaccgcttggcaaactccAcgatcttgatgatgcacttg	9	12	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:53607931A>G	uc001sce.2	-	7	1210	c.725T>C	c.(724-726)GTG>GCG	p.V242A	RARG_uc001scd.2_Missense_Mutation_p.V231A|RARG_uc010sob.1_Missense_Mutation_p.V220A|RARG_uc001scf.2_Missense_Mutation_p.V242A|RARG_uc001scg.2_Missense_Mutation_p.V170A|RARG_uc010soc.1_Missense_Mutation_p.V121A|RARG_uc010sod.1_Missense_Mutation_p.V279A	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	242	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGCAAACTCCACGATCTTGAT	0.557											OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003271	0	37	122										G	53607931	A	G	53607931	3	3	128	1	0	0	0	0	1	0	0	0	13054	159	6	5	655	5	RARG	12	53607931	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	1228869	53607931	80243964	202	38241										
ESPL1	9700	broad.mit.edu	37	chr12	53673530	53673530	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaccagcccatgcaggctctGgaggtcctcctgctgctacg	12	15	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:53673530G>A	uc001sck.2	+	12	2470	c.2379G>A	c.(2377-2379)CTG>CTA	p.L793L	ESPL1_uc001scj.2_Silent_p.L468L|ESPL1_uc010soe.1_Silent_p.L4L	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	793					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						TGCAGGCTCTGGAGGTCCTCC	0.597													0	0	0	0.006999	0	38	87										A	53673530	G	A	53673530	2	1	128	1	0	0	0	0	0	0	0	1	5253	1335	47	2		2	ESPL1	12	53673530	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	65599	53673530	80178365	203	38242										
RASSF3	283349	broad.mit.edu	37	chr12	65088574	65088583	+	Frame_Shift_Del	DEL	ATTTCTTGCG	ATTTCTTGCG	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cagccttccagaactacagaAtttcttgcgcatcttggaca					rs147804503		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:65088574_65088583delATTTCTTGCG	uc001ssd.2	+	5	719_728	c.599_608delATTTCTTGCG	c.(598-609)AATTTCTTGCGCfs	p.N200fs	RASSF3_uc009zqn.2_RNA|RASSF3_uc001sse.2_Frame_Shift_Del_p.N130fs	NM_178169	NP_835463	Q86WH2	RASF3_HUMAN	Ras association (RalGDS/AF-6) domain family	200_203	SARAH.				signal transduction	cytoplasm|microtubule	identical protein binding				0			Lung(2;0.00133)|LUAD - Lung adenocarcinoma(6;0.0665)|LUSC - Lung squamous cell carcinoma(43;0.132)	GBM - Glioblastoma multiforme(28;0.0611)		GAACTACAGAATTTCTTGCGCATCTTGGAC	0.481																		14	74	---	---								-	65088583	ATTTCTTGCG	-	65088574	7	5	128	1	0	1	0	1	0	0	0	0	13087	101	4	0	617	0	RASSF3	12	65088574	Frame_Shift_Del	DEL	ATTTCTTGCG	TCGA-K4-A3WS-01A-11D-A22Z-08	11415044	65088574	68763321	204	38243										
PAWR	5074	broad.mit.edu	37	chr12	79986470	79986470	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcatcttctatgtcatctaGgtccttaagaaaaaaaaaag	5	7	5	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:79986470G>A	uc001syx.2	-	7	1226	c.940C>T	c.(940-942)CTA>TTA	p.L314L		NM_002583	NP_002574	Q96IZ0	PAWR_HUMAN	PRKC, apoptosis, WT1, regulator	314	Leucine-zipper.				actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0						ATGTCATCTAGGTCCTTAAGA	0.234													0	0	0	0.001984	0	6	23										A	79986470	G	A	79986470	2	1	128	1	0	0	0	0	0	0	0	1	11477	991	35	2		2	PAWR	12	79986470	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	14897896	79986470	53865425	205	38244										
ACSS3	79611	broad.mit.edu	37	chr12	81648681	81648681	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcatttttggccacgtagaaGaaatgctgaagcaagcataa	10	7	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:81648681G>T	uc001szl.1	+	16	2132	c.2041G>T	c.(2041-2043)GAA>TAA	p.E681*	ACSS3_uc001szm.1_Nonsense_Mutation_p.E680*|ACSS3_uc001szn.1_Nonsense_Mutation_p.E363*	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	681						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCACGTAGAAGAAATGCTGAA	0.308													1	0	1.12685e-05	0.004482	1.2279e-05	9	65										T	81648681	G	T	81648681	4	4	128	1	0	0	0	0	0	1	0	0	190	943	33	3	2103	3	ACSS3	12	81648681	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1662211	81648681	52203214	206	38245										
CRY1	1407	broad.mit.edu	37	chr12	107393605	107393606	+	Frame_Shift_Ins	INS	-	-	T													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cacgccataacagttgcccaINStaaagggaaaggggagggga							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:107393605_107393606insT	uc001tmi.3	-	7	1719_1720	c.860_861insA	c.(859-861)TATfs	p.Y287fs		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	287	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						ACAGTTGCCCATAAAGGGAAAG	0.351																		19	55	---	---								T	107393606	-	T	107393605	7	5	128	1	0	1	1	0	0	0	0	0	3903	224	8	0	923	0	CRY1	12	107393605	Frame_Shift_Ins	INS	-	TCGA-K4-A3WS-01A-11D-A22Z-08	25744924	107393605	26458290	207	38246										
CUX2	23316	broad.mit.edu	37	chr12	111779715	111779715	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcagatcaagaagccccggGtggtgctggcacccgaggag	16	11	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:111779715G>T	uc001tsa.1	+	21	3670	c.3517G>T	c.(3517-3519)GTG>TTG	p.V1173L		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1173	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GAAGCCCCGGGTGGTGCTGGC	0.662													1	0	5.16669e-11	0.010729	6.02279e-11	12	58										T	111779715	G	T	111779715	3	4	128	1	0	0	0	0	1	0	0	0	4065	1261	44	4	3599	4	CUX2	12	111779715	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4386110	111779715	22072180	208	38247										
RPL6	6128	broad.mit.edu	37	chr12	112846122	112846122	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtaacagttgcgagaaccttCtccttctttttcttttcaac	5	11	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:112846122C>G	uc001ttu.2	-	3	487	c.258G>C	c.(256-258)GAG>GAC	p.E86D	RPL6_uc001ttv.2_Missense_Mutation_p.E86D|RPL6_uc009zwd.1_3'UTR	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6	86					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1						CGAGAACCTTCTCCTTCTTTT	0.433													0	0	0	0.00245	0	15	97										G	112846122	C	G	112846122	3	3	128	1	0	0	0	0	1	0	0	0	13598	912	32	1	628	1	RPL6	12	112846122	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1066407	112846122	21005773	209	38248										
OAS2	4939	broad.mit.edu	37	chr12	113445538	113445538	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaaactgaagccaaaggggtCtttgcccccaaagtatgcct	10	11	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr12:113445538C>G	uc001tuj.2	+	9	1825	c.1685C>G	c.(1684-1686)TCT>TGT	p.S562C	OAS2_uc001tui.1_Missense_Mutation_p.S562C	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	562	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						CCAAAGGGGTCTTTGCCCCCA	0.547													0	0	0	0.006122	0	19	108										G	113445538	C	G	113445538	3	3	128	1	0	0	0	0	1	0	0	0	10800	913	32	1	1790	1	OAS2	12	113445538	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	599416	113445538	20406357	210	38249										
SACS	26278	broad.mit.edu	37	chr13	23904689	23904689	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctgcgtgcttccactggattGccaaccgacttgaaagtggg	12	11	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:23904689G>T	uc001uon.2	-	10	13915	c.13326C>A	c.(13324-13326)GGC>GGA	p.G4442G	SACS_uc001uoo.2_Silent_p.G4295G|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4442					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CCACTGGATTGCCAACCGACT	0.468													1	0	3.90053e-15	0.012213	4.65509e-15	29	112										T	23904689	G	T	23904689	2	4	128	1	0	0	0	0	0	0	0	1	13804	1306	46	4		4	SACS	13	23904689	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		23904689	91265189	211	38250										
SLC7A1	6541	broad.mit.edu	37	chr13	30107006	30107006	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcgaatatgtcggggttttCagccagcacgccgggggcgt	16	10	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:30107006C>G	uc001uso.2	-	4	871	c.484G>C	c.(484-486)GAA>CAA	p.E162Q		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	162	Extracellular (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCGGGGTTTTCAGCCAGCACG	0.547													0	0	0	0.014323	0	21	77										G	30107006	C	G	30107006	3	3	128	1	0	0	0	0	1	0	0	0	14692	835	29	1	1445	1	SLC7A1	13	30107006	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	6202317	30107006	85062872	212	38251										
FRY	10129	broad.mit.edu	37	chr13	32841467	32841467	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atggctcctgtgctgtgtatAcatttcatgtgttctcctcc	8	11	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:32841467A>C	uc001utx.2	+	55	8603	c.8107A>C	c.(8107-8109)ACA>CCA	p.T2703P	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_Missense_Mutation_p.T258P|FRY_uc001utz.2_Missense_Mutation_p.T228P|FRY_uc010tdx.1_Missense_Mutation_p.T73P	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2703					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TGCTGTGTATACATTTCATGT	0.512													0	0	0	0.004482	0	8	58										C	32841467	A	C	32841467	3	2	128	1	0	0	0	0	1	0	0	0	6063	391	14	5	8325	5	FRY	13	32841467	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	2734461	32841467	82328411	213	38252										
BRCA2	675	broad.mit.edu	37	chr13	32945213	32945213	+	Nonsense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagccttattcactaaaattCaggaggaatttgaagaacat	7	6	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:32945213C>T	uc001uub.1	+	20	8835	c.8608C>T	c.(8608-8610)CAG>TAG	p.Q2870*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2870					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CACTAAAATTCAGGAGGAATT	0.318			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.013537	0	12	51										T	32945213	C	T	32945213	4	4	128	1	0	0	0	0	0	1	0	0	1499	827	29	1	8682	1	BRCA2	13	32945213	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	103746	32945213	82224665	214	38253										
MAB21L1	4081	broad.mit.edu	37	chr13	36049441	36049441	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgcttttcacactcgtaggAaaccagagtcttcatatggt	8	9	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:36049441A>G	uc001uvc.2	-	1	1392	c.835T>C	c.(835-837)TCC>CCC	p.S279P	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	279					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CACTCGTAGGAAACCAGAGTC	0.522													0	0	0	0.006214	0	10	80										G	36049441	A	G	36049441	3	3	128	1	0	0	0	0	1	0	0	0	9141	246	9	5	248	5	MAB21L1	13	36049441	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	3104228	36049441	79120437	215	38254										
POSTN	10631	broad.mit.edu	37	chr13	38153448	38153448	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atccttttccaatgaaaactCctggtgtcaggtgataaaga	8	8	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:38153448C>G	uc001uwo.3	-	13	1827	c.1709G>C	c.(1708-1710)GGA>GCA	p.G570A	POSTN_uc010tet.1_Missense_Mutation_p.G98A|POSTN_uc001uwp.3_Missense_Mutation_p.G570A|POSTN_uc001uwr.2_Missense_Mutation_p.G570A|POSTN_uc001uwq.2_Missense_Mutation_p.G570A|POSTN_uc010teu.1_Missense_Mutation_p.G570A|POSTN_uc010tev.1_Missense_Mutation_p.G570A|POSTN_uc010tew.1_Missense_Mutation_p.G570A|POSTN_uc010tex.1_Missense_Mutation_p.G485A	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	570	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AATGAAAACTCCTGGTGTCAG	0.318													0	0	0	0.001855	0	14	74										G	38153448	C	G	38153448	3	3	128	1	0	0	0	0	1	0	0	0	12259	855	30	1	845	1	POSTN	13	38153448	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2104007	38153448	77016430	216	38255										
INTS6	26512	broad.mit.edu	37	chr13	51950240	51950240	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcaaaagattagatctcattCttgttaagtgatccaaaaga	6	6	3	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:51950240C>G	uc001vfk.2	-	13	2287	c.1673G>C	c.(1672-1674)AGA>ACA	p.R558T	INTS6_uc001vfi.2_Missense_Mutation_p.R242T|INTS6_uc001vfj.2_Missense_Mutation_p.R545T|INTS6_uc001vfl.2_Missense_Mutation_p.R380T	NM_012141	NP_036273	Q9UL03	INT6_HUMAN	integrator complex subunit 6 isoform a	558					snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)		AGATCTCATTCTTGTTAAGTG	0.323													0	0	0	0.013537	0	13	28										G	51950240	C	G	51950240	3	3	128	1	0	0	0	0	1	0	0	0	7782	913	32	1	1014	1	INTS6	13	51950240	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	13796792	51950240	63219638	217	38256										
RNF113B	140432	broad.mit.edu	37	chr13	98828982	98828982	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tggggcccttcctcgccatcCccgaggaggagttgcccatg	13	15	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:98828982C>T	uc001vnk.2	-	1	540	c.509G>A	c.(508-510)GGG>GAG	p.G170E	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	170							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			CCTCGCCATCCCCGAGGAGGA	0.632													0	0	0	0.001984	0	7	30										T	98828982	C	T	98828982	3	4	128	1	0	0	0	0	1	0	0	0	13428	623	22	2	467	2	RNF113B	13	98828982	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	46878742	98828982	16340896	218	38257										
DAOA	267012	broad.mit.edu	37	chr13	106124975	106124975	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggctatttggaaatggcacaGaggcatttacagagatcatt	11	6	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr13:106124975G>C	uc001vqb.2	+	3	496	c.222G>C	c.(220-222)CAG>CAC	p.Q74H	DAOA_uc010tjf.1_Missense_Mutation_p.Q3H|DAOA_uc001vpz.2_RNA|DAOA_uc010agd.2_RNA|DAOA_uc010tjg.1_Missense_Mutation_p.R10T|DAOA_uc001vqc.2_RNA|DAOA_uc001vqe.2_RNA	NM_172370	NP_758958	P59103	DAOA_HUMAN	D-amino acid oxidase activator isoform 1	74						Golgi apparatus					0	Lung NSC(43;0.01)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					AAATGGCACAGAGGCATTTAC	0.428													0	0	0	0.001168	0	6	39										C	106124975	G	C	106124975	3	2	128	1	0	0	0	0	1	0	0	0	4232	942	33	1	232	1	DAOA	13	106124975	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	7295993	106124975	9044903	219	38258										
SUPT16H	11198	broad.mit.edu	37	chr14	21821928	21821928	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ttcctcttcatagtcatcttCtgaaggattaaaagtctcat	5	9	6	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:21821928C>T	uc001wao.2	-	24	3193	c.2854G>A	c.(2854-2856)GAA>AAA	p.E952K	SUPT16H_uc001wan.2_Missense_Mutation_p.E96K	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	952	Glu-rich (acidic).				DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TAGTCATCTTCTGAAGGATTA	0.408													0	0	0	0.00308	0	7	86										T	21821928	C	T	21821928	3	4	128	1	0	0	0	0	1	0	0	0	15393	922	32	1	301	1	SUPT16H	14	21821928	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		21821928	85527612	220	38259										
C14orf21	161424	broad.mit.edu	37	chr14	24769358	24769358	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaagctctgggatatttccgCcgggcgctgtcagcattgaa	13	10	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:24769358C>T	uc001wol.1	+	1	261	c.198C>T	c.(196-198)CGC>CGT	p.R66R	C14orf21_uc001wom.1_5'Flank|DHRS1_uc001woj.1_5'Flank|DHRS1_uc001wok.2_5'Flank	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	66							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		GATATTTCCGCCGGGCGCTGT	0.637													0	0	0	0.010729	0	12	92										T	24769358	C	T	24769358	2	4	128	1	0	0	0	0	0	0	0	1	1769	726	26	2		2	C14orf21	14	24769358	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2947430	24769358	82580182	221	38260										
PELI2	57161	broad.mit.edu	37	chr14	56746399	56746399	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaattttattattaggctatCagctgcaaaggtcaacacag	7	7	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:56746399C>G	uc001xch.2	+	3	499	c.213C>G	c.(211-213)ATC>ATG	p.I71M		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	71					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						attaGGCTATCAGCTGCAAAG	0.373													0	0	0	0.00245	0	15	54										G	56746399	C	G	56746399	3	3	128	1	0	0	0	0	1	0	0	0	11722	816	29	1	223	1	PELI2	14	56746399	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	31977041	56746399	50603141	222	38261										
VTI1B	10490	broad.mit.edu	37	chr14	68129250	68129250	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctgatcaatttcttcttttCttctagaaaagatagataag	5	7	5	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:68129250C>T	uc001xjt.2	-	2	514	c.118G>A	c.(118-120)GAA>AAA	p.E40K	VTI1B_uc010aqp.2_5'UTR|VTI1B_uc001xju.2_Intron	NM_006370	NP_006361	Q9UEU0	VTI1B_HUMAN	vesicle transport through interaction with	40	Potential.|Cytoplasmic (Potential).				cell proliferation|cellular membrane fusion|intracellular protein transport|vesicle docking involved in exocytosis	endomembrane system|integral to membrane					0				all cancers(60;0.000344)|OV - Ovarian serous cystadenocarcinoma(108;0.00212)|BRCA - Breast invasive adenocarcinoma(234;0.00941)		TTCTTCTTTTCTTCTAGAAAA	0.224													0	0	0	0.001168	0	6	35										T	68129250	C	T	68129250	3	4	128	1	0	0	0	0	1	0	0	0	17233	922	32	1	600	1	VTI1B	14	68129250	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	11382851	68129250	39220290	223	38262										
LTBP2	4053	broad.mit.edu	37	chr14	75018986	75018986	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctccctggaggctccctgtCcggctgcgggataggcaggt	15	14	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:75018986C>G	uc001xqa.2	-	6	1690	c.1303G>C	c.(1303-1305)GAC>CAC	p.D435H		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	435					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGCTCCCTGTCCGGCTGCGGG	0.672													0	0	0	0.000602	0	4	51										G	75018986	C	G	75018986	3	3	128	1	0	0	0	0	1	0	0	0	9074	855	30	1	4286	1	LTBP2	14	75018986	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	6889736	75018986	32330554	224	38263										
YLPM1	56252	broad.mit.edu	37	chr14	75230761	75230761	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctgcctcctgctcagccgtCcccttcgcagtccccacctt	6	22	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:75230761C>G	uc001xqj.3	+	1	693	c.569C>G	c.(568-570)TCC>TGC	p.S190C		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCTCAGCCGTCCCCTTCGCAG	0.597													0	0	0	0.004482	0	8	42										G	75230761	C	G	75230761	3	3	128	1	0	0	0	0	1	0	0	0	17483	855	30	1	571	1	YLPM1	14	75230761	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	211775	75230761	32118779	225	38264										
ATXN3	4287	broad.mit.edu	37	chr14	92537344	92537344	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atggatgtgaactctgtcctGataggtccccctgctgctgc	11	12	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:92537344G>T	uc001yac.3	-	10	995	c.926C>A	c.(925-927)TCA>TAA	p.S309*	ATXN3_uc010aug.2_Nonsense_Mutation_p.S294*|ATXN3_uc001yad.3_Nonsense_Mutation_p.S254*|ATXN3_uc010auh.2_Nonsense_Mutation_p.S243*|ATXN3_uc001yae.3_Nonsense_Mutation_p.S211*	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	309					cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		ACTCTGTCCTGATAGGTCCCC	0.343													1	0	2.47511e-08	0.008361	2.82769e-08	32	39										T	92537344	G	T	92537344	4	4	128	1	0	0	0	0	0	1	0	0	1213	1294	45	3	167	3	ATXN3	14	92537344	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	17306583	92537344	14812196	226	38265										
BTBD7	55727	broad.mit.edu	37	chr14	93709011	93709011	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atattctctcctagcttcttCctgttttttaggagacgtct	6	10	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr14:93709011C>A	uc001ybo.2	-	11	3333	c.3007G>T	c.(3007-3009)GAA>TAA	p.E1003*	BTBD7_uc010aur.2_Nonsense_Mutation_p.E528*|BTBD7_uc010two.1_Nonsense_Mutation_p.E823*|BTBD7_uc001ybp.2_Nonsense_Mutation_p.E652*	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	1003										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		CTAGCTTCTTCCTGTTTTTTA	0.493													1	0	2.5401e-28	0.01441	3.05879e-28	59	87										A	93709011	C	A	93709011	4	1	128	1	0	0	0	0	0	1	0	0	1546	864	30	3	395	3	BTBD7	14	93709011	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1171667	93709011	13640529	227	38266										
C15orf2	23742	broad.mit.edu	37	chr15	24922473	24922473	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaggaggctcttataattcaGtcgtaggagcagcgcctctc	11	10	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:24922473G>T	uc001ywo.2	+	1	1933	c.1459G>T	c.(1459-1461)GTC>TTC	p.V487F		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	487	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTATAATTCAGTCGTAGGAGC	0.507													1	0	8.34094e-07	0.008871	9.29088e-07	21	167										T	24922473	G	T	24922473	3	4	128	1	0	0	0	0	1	0	0	0	1784	1029	36	4	1461	4	C15orf2	15	24922473	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		24922473	77608919	228	38267										
NDUFAF1	51103	broad.mit.edu	37	chr15	41687143	41687143	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctggaagaaatctgtgtcctCcttgatattcaccatccaag	7	11	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:41687143C>A	uc001znx.2	-	3	1055	c.673G>T	c.(673-675)GAG>TAG	p.E225*	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	225					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		TCTGTGTCCTCCTTGATATTC	0.488													1	0	3.07112e-06	0.010729	3.39261e-06	12	39										A	41687143	C	A	41687143	4	1	128	1	0	0	0	0	0	1	0	0	10274	864	30	3	322	3	NDUFAF1	15	41687143	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	16764670	41687143	60844249	229	38268										
TP53BP1	7158	broad.mit.edu	37	chr15	43738684	43738684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atccacgtctggggcagcccCagaatccccttttccactcc	7	18	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:43738684C>T	uc001zrs.2	-	14	3074	c.2926G>A	c.(2926-2928)GGG>AGG	p.G976R	TP53BP1_uc010udp.1_Missense_Mutation_p.G976R|TP53BP1_uc001zrq.3_Missense_Mutation_p.G981R|TP53BP1_uc001zrr.3_Missense_Mutation_p.G981R|TP53BP1_uc010udq.1_Missense_Mutation_p.G981R	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	976					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GGGGCAGCCCCAGAATCCCCT	0.473								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.009535	0	29	76										T	43738684	C	T	43738684	3	4	128	1	0	0	0	0	1	0	0	0	16380	594	21	2	3052	2	TP53BP1	15	43738684	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2051541	43738684	58792708	230	38269										
DUT	1854	broad.mit.edu	37	chr15	48626677	48626677	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaaacggacattcagatagcGctcccttctgggtgttatgg	11	9	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:48626677G>A	uc001zws.2	+	3	575	c.483G>A	c.(481-483)GCG>GCA	p.A161A	DUT_uc001zwt.2_Silent_p.A50A|DUT_uc001zwu.2_RNA|DUT_uc001zwv.2_Silent_p.A73A|DUT_uc001zww.2_Silent_p.A73A|uc010ben.1_5'Flank	NM_001025248	NP_001020419	P33316	DUT_HUMAN	deoxyuridine triphosphatase isoform 1 precursor	161					DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding				0		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)		TTCAGATAGCGCTCCCTTCTG	0.363								Modulation_of_nucleotide_pools					0	0	0	0.001168	0	6	39										A	48626677	G	A	48626677	2	1	128	1	0	0	0	0	0	0	0	1	4833	1074	38	2		2	DUT	15	48626677	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	4887993	48626677	53904715	231	38270										
C15orf33	196951	broad.mit.edu	37	chr15	49800544	49800544	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagcctttttgaggttttaaAcctgttaatataaaatacat	5	5	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:49800544A>C	uc001zxl.2	-	11	1170	c.876T>G	c.(874-876)GGT>GGG	p.G292G	C15orf33_uc001zxm.2_Silent_p.G258G	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	292										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		GAGGTTTTAAACCTGTTAATA	0.303													0	0	0	0.001168	0	6	44										C	49800544	A	C	49800544	2	2	128	1	0	0	0	0	0	0	0	1	1791	57	2	5		5	C15orf33	15	49800544	Silent	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	1173867	49800544	52730848	232	38271										
AP4E1	23431	broad.mit.edu	37	chr15	51289655	51289655	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctttgtcaaatgtggcatatGaagatgattattattcgaat	8	4	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:51289655G>A	uc001zyx.1	+	18	2509	c.2479G>A	c.(2479-2481)GAA>AAA	p.E827K	AP4E1_uc010bex.1_RNA	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	827					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TGTGGCATATGAAGATGATTA	0.353													0	0	0	0.004482	0	9	55										A	51289655	G	A	51289655	3	1	128	1	0	0	0	0	1	0	0	0	752	1291	45	1	2549	1	AP4E1	15	51289655	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1489111	51289655	51241737	233	38272										
KIAA1370	56204	broad.mit.edu	37	chr15	52902491	52902491	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaacactgactttcaaggcaAcattgtgagaaacattggga	10	7	1	2	rs61731677	by1000genomes	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:52902491A>G	uc002acg.3	-	6	773	c.620T>C	c.(619-621)GTT>GCT	p.V207A	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.V119A|KIAA1370_uc010ugf.1_Missense_Mutation_p.V214A	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	207				V -> A (in Ref. 2; BAF85606).							0				all cancers(107;0.0803)		TTTCAAGGCAACATTGTGAGA	0.393													0	0	0	0.009096	0	4	64										G	52902491	A	G	52902491	3	3	128	1	0	0	0	0	1	0	0	0	8226	43	2	5	2642	5	KIAA1370	15	52902491	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	1612836	52902491	49628901	234	38273										
MPI	4351	broad.mit.edu	37	chr15	75190013	75190013	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tggggccaatgagagtgtctCactgaagcttactgagccga	13	9	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:75190013C>T	uc002azc.1	+	8	1219	c.1214C>T	c.(1213-1215)TCA>TTA	p.S405L	MPI_uc002azd.1_3'UTR|MPI_uc010ulx.1_Missense_Mutation_p.S355L|MPI_uc002aze.1_Missense_Mutation_p.S344L	NM_002435	NP_002426	P34949	MPI_HUMAN	mannose-6- phosphate isomerase	405					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			ovary(2)	2						GAGAGTGTCTCACTGAAGCTT	0.562													0	0	0	0.009096	0	4	46										T	75190013	C	T	75190013	3	4	128	1	0	0	0	0	1	0	0	0	9729	838	29	1	1244	1	MPI	15	75190013	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	22287522	75190013	27341379	235	38274										
FAH	2184	broad.mit.edu	37	chr15	80467381	80467381	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cccaggcccctgccgtatctGtgccatgacgagccctacac	9	18	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:80467381G>T	uc002bfj.2	+	11	943	c.861G>T	c.(859-861)CTG>CTT	p.L287L	FAH_uc002bfk.1_Silent_p.L287L|FAH_uc002bfm.1_Silent_p.L287L|FAH_uc002bfn.1_Silent_p.L217L|FAH_uc010bln.1_5'Flank|FAH_uc010blo.1_5'Flank	NM_000137	NP_000128	P16930	FAAA_HUMAN	fumarylacetoacetase	287					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding				0						TGCCGTATCTGTGCCATGACG	0.587									Tyrosinemia_type_1				1	0	1.12685e-05	0.004482	1.2279e-05	8	47										T	80467381	G	T	80467381	2	4	128	1	0	0	0	0	0	0	0	1	5371	1364	48	4		4	FAH	15	80467381	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	5277368	80467381	22064011	236	38275										
AKAP13	11214	broad.mit.edu	37	chr15	86273898	86273898	+	Silent	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgctccaacacagaagaggcTctcaaaggaggacctttaat	9	11	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:86273898T>A	uc002blv.1	+	30	7412	c.7242T>A	c.(7240-7242)GCT>GCA	p.A2414A	AKAP13_uc002blu.1_Silent_p.A2418A|AKAP13_uc002blw.1_Silent_p.A879A|AKAP13_uc002blx.1_Silent_p.A659A	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2414	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CAGAAGAGGCTCTCAAAGGAG	0.478											OREG0023425	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00499	0	17	73										A	86273898	T	A	86273898	2	1	128	1	0	0	0	0	0	0	0	1	449	1538	54	5		5	AKAP13	15	86273898	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	5806517	86273898	16257494	237	38276										
ACAN	176	broad.mit.edu	37	chr15	89391184	89391184	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	accccatgcgtgggtgacaaGgacagcagcccaggggtcag	15	12	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:89391184G>A	uc010upo.1	+	9	2021	c.1647G>A	c.(1645-1647)AAG>AAA	p.K549K	ACAN_uc002bmx.2_Silent_p.K549K|ACAN_uc010upp.1_Silent_p.K549K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	549					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGGGTGACAAGGACAGCAGCC	0.572													0	0	0	0.004482	0	9	72										A	89391184	G	A	89391184	2	1	128	1	0	0	0	0	0	0	0	1	117	991	35	2		2	ACAN	15	89391184	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3117286	89391184	13140208	238	38277										
IGF1R	3480	broad.mit.edu	37	chr15	99491937	99491937	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agacaactgtcctgacatgcTgtacgtacttcctgggccct	9	13	0	2	rs45504297		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr15:99491937T>G	uc002bul.2	+	20	3772	c.3722T>G	c.(3721-3723)CTG>CGG	p.L1241R	IGF1R_uc010bon.2_Missense_Mutation_p.L1240R	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1241	Protein kinase.|Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CCTGACATGCTGTACGTACTT	0.537													0	0	0	0.00308	0	7	71										G	99491937	T	G	99491937	3	3	128	1	0	0	0	0	1	0	0	0	7571	1594	55	5	3800	5	IGF1R	15	99491937	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	10100753	99491937	3039455	239	38278										
NARFL	64428	broad.mit.edu	37	chr16	786283	786283	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tacctatttttttaaagaatGaggttaatttcctggcagta	7	5	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr16:786283G>C	uc002cjr.2	-	4	434	c.422C>G	c.(421-423)TCA>TGA	p.S141*	NARFL_uc002cjp.2_Nonsense_Mutation_p.S39*|NARFL_uc002cjq.2_Nonsense_Mutation_p.S39*|NARFL_uc002cjs.2_Intron|NARFL_uc010brc.1_Intron|NARFL_uc010uur.1_Intron	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	141					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				TTTAAAGAATGAGGTTAATTT	0.522													0	0	0	0.001984	0	7	54										C	786283	G	C	786283	4	2	128	1	0	0	0	0	0	1	0	0	10168	1294	45	1	1040	1	NARFL	16	786283	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		786283	89568470	240	38279										
PRR14	78994	broad.mit.edu	37	chr16	30665636	30665636	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agccatctgctctgcctgcaGaccctctggagagcccacca	9	17	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr16:30665636G>C	uc002dyy.2	+	7	892	c.634G>C	c.(634-636)GAC>CAC	p.D212H	PRR14_uc002dyz.2_Missense_Mutation_p.D57H|PRR14_uc002dza.2_Missense_Mutation_p.D212H|PRR14_uc002dzb.1_Missense_Mutation_p.D26H	NM_024031	NP_076936	Q9BWN1	PRR14_HUMAN	proline rich 14	212	Pro-rich.										0			Colorectal(24;0.103)			TCTGCCTGCAGACCCTCTGGA	0.577													0	0	0	0.00623	0	40	128										C	30665636	G	C	30665636	3	2	128	1	0	0	0	0	1	0	0	0	12586	942	33	1	656	1	PRR14	16	30665636	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	29879353	30665636	59689117	241	38280										
ATP6V0D1	9114	broad.mit.edu	37	chr16	67514921	67514921	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tggctgagcaccccggccttCaggccgcgcaccagtccctc	11	19	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr16:67514921C>T	uc002ete.1	-	1	169	c.69G>A	c.(67-69)CTG>CTA	p.L23L	ATP6V0D1_uc010vjo.1_Silent_p.L23L	NM_004691	NP_004682	P61421	VA0D1_HUMAN	ATPase, H+ transporting, lysosomal, V0 subunit	23					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0439)|Epithelial(162;0.101)		CCCCGGCCTTCAGGCCGCGCA	0.652													0	0	0	0.003163	0	15	44										T	67514921	C	T	67514921	2	4	128	1	0	0	0	0	0	0	0	1	1173	813	29	1		1	ATP6V0D1	16	67514921	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	36849285	67514921	22839832	242	38281										
FAM65A	79567	broad.mit.edu	37	chr16	67578265	67578265	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcacccagtgcccgccccctCagcacggggtgtccagctct	10	19	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr16:67578265C>T	uc010vjp.1	+	15	2820	c.2724C>T	c.(2722-2724)CTC>CTT	p.L908L	FAM65A_uc002eth.2_Silent_p.L888L|FAM65A_uc010cej.2_Silent_p.L891L|FAM65A_uc010vjq.1_Silent_p.L902L|FAM65A_uc002etk.2_Silent_p.L886L	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	892						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCCGCCCCCTCAGCACGGGGT	0.652													0	0	0	0.00632	0	28	73										T	67578265	C	T	67578265	2	4	128	1	0	0	0	0	0	0	0	1	5599	813	29	1		1	FAM65A	16	67578265	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	63344	67578265	22776488	243	38282										
ZC3H18	124245	broad.mit.edu	37	chr16	88643559	88643559	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tggccgagagccctgaacggGatcctcactctccagaggat	12	13	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr16:88643559G>C	uc002fky.2	+	2	228	c.28G>C	c.(28-30)GAT>CAT	p.D10H	ZC3H18_uc010voy.1_Missense_Mutation_p.D10H|ZC3H18_uc010voz.1_Missense_Mutation_p.D10H|ZC3H18_uc010vpa.1_Missense_Mutation_p.D10H	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	10						nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CCCTGAACGGGATCCTCACTC	0.547													0	0	0	0.001984	0	7	42										C	88643559	G	C	88643559	3	2	128	1	0	0	0	0	1	0	0	0	17565	1174	41	1	30	1	ZC3H18	16	88643559	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	21065294	88643559	1711194	244	38283										
ANKFY1	51479	broad.mit.edu	37	chr17	4080500	4080500	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tggaggcatcctggactcttGaattcacattagcgtggaca	11	9	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:4080500G>A	uc002fxq.1	-	19	2734	c.2696C>T	c.(2695-2697)TCA>TTA	p.S899L	ANKFY1_uc002fxn.2_Missense_Mutation_p.S941L|ANKFY1_uc002fxo.2_Missense_Mutation_p.S900L|ANKFY1_uc002fxp.2_Missense_Mutation_p.S898L|ANKFY1_uc010ckp.2_Missense_Mutation_p.S841L	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	899	ANK 16.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						CTGGACTCTTGAATTCACATT	0.473													0	0	0	0.004656	0	27	47										A	4080500	G	A	4080500	3	1	128	1	0	0	0	0	1	0	0	0	626	1294	45	1	841	1	ANKFY1	17	4080500	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08		4080500	77114710	245	38284										
ANKFY1	51479	broad.mit.edu	37	chr17	4080558	4080558	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	actttcaatatcagagttctGaactgccacatgaaggaaat	7	8	3	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:4080558G>A	uc002fxq.1	-	19	2676	c.2638C>T	c.(2638-2640)CAG>TAG	p.Q880*	ANKFY1_uc002fxn.2_Nonsense_Mutation_p.Q922*|ANKFY1_uc002fxo.2_Nonsense_Mutation_p.Q881*|ANKFY1_uc002fxp.2_Nonsense_Mutation_p.Q879*|ANKFY1_uc010ckp.2_Nonsense_Mutation_p.Q822*	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	880	ANK 16.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						TCAGAGTTCTGAACTGCCACA	0.473													0	0	0	0.005443	0	28	53										A	4080558	G	A	4080558	4	1	128	1	0	0	0	0	0	1	0	0	626	1299	45	1	899	1	ANKFY1	17	4080558	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	58	4080558	77114652	246	38285										
DNAH2	146754	broad.mit.edu	37	chr17	7710807	7710807	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gctgtatgggcggctatatcGggtggtggagcccaagcgaa	17	8	0	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:7710807G>C	uc002giu.1	+	62	9646	c.9632G>C	c.(9631-9633)CGG>CCG	p.R3211P	DNAH2_uc010cnm.1_Missense_Mutation_p.R149P	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3211	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CGGCTATATCGGGTGGTGGAG	0.642													0	0	0	0.001168	0	5	53										C	7710807	G	C	7710807	3	2	128	1	0	0	0	0	1	0	0	0	4602	1116	39	4	9878	4	DNAH2	17	7710807	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3630249	7710807	73484403	247	38286										
PIPOX	51268	broad.mit.edu	37	chr17	27380490	27380490	+	Frame_Shift_Del	DEL	C	C	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gagaaggtggtggagataaaCccagggctactggtcacggt							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:27380490delC	uc002hdr.1	+	4	863	c.537delC	c.(535-537)AACfs	p.N179fs		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	179					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	TGGAGATAAACCCAGGGCTAC	0.542																		7	90	---	---								-	27380490	C	-	27380490	7	5	128	1	0	1	0	1	0	0	0	0	11943	506	18	0	551	0	PIPOX	17	27380490	Frame_Shift_Del	DEL	C	TCGA-K4-A3WS-01A-11D-A22Z-08	19669683	27380490	53814720	248	38287										
RAD51L3	5892	broad.mit.edu	37	chr17	33427979	33427979	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acaacagcacaggtcatgtcTgatcaccctgtaatgtggca	9	11	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:33427979T>G	uc002hir.2	-	10	1236	c.980A>C	c.(979-981)CAG>CCG	p.Q327P	RFFL_uc002hiq.2_Intron|RAD51L3_uc010ctj.2_3'UTR|RAD51L3_uc010wcd.1_Missense_Mutation_p.Q347P|RAD51L3_uc002his.2_Missense_Mutation_p.Q215P|RAD51L3_uc010ctk.2_Missense_Mutation_p.Q208P|RAD51L3_uc010wce.1_Missense_Mutation_p.Q208P|RAD51L3_uc002hit.2_Missense_Mutation_p.Q208P|RAD51L3_uc002hiu.2_Missense_Mutation_p.Q150P	NM_002878	NP_002869	O75771	RA51D_HUMAN	RAD51-like 3 isoform 1	327					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AGGTCATGTCTGATCACCCTG	0.532								Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.00499	0	16	61										G	33427979	T	G	33427979	3	3	128	1	0	0	0	0	1	0	0	0	12990	1580	55	5	10	5	RAD51L3	17	33427979	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	6047489	33427979	47767231	249	38288										
MRM1	79922	broad.mit.edu	37	chr17	34958603	34958603	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tccaccagggtgtctgcatgGaggtgagcccgctgcggccc	15	14	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:34958603G>C	uc002hne.2	+	1	579	c.364G>C	c.(364-366)GAG>CAG	p.E122Q	MRM1_uc002hnf.2_5'UTR	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	122					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGTCTGCATGGAGGTGAGCCC	0.682													0	0	0	0.004672	0	3	35										C	34958603	G	C	34958603	3	2	128	1	0	0	0	0	1	0	0	0	9771	1175	41	1	366	1	MRM1	17	34958603	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1530624	34958603	46236607	250	38289										
ACACA	31	broad.mit.edu	37	chr17	35591979	35591979	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gttcatgtcacttttattctCttctcggagggcgaatacac	8	10	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:35591979C>G	uc002hnm.2	-	25	3237	c.3046G>C	c.(3046-3048)GAG>CAG	p.E1016Q	ACACA_uc002hnk.2_Missense_Mutation_p.E938Q|ACACA_uc002hnl.2_Missense_Mutation_p.E958Q|ACACA_uc002hnn.2_Missense_Mutation_p.E1016Q|ACACA_uc002hno.2_Missense_Mutation_p.E1053Q|ACACA_uc010cuz.2_Missense_Mutation_p.E1016Q	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1016					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTTTTATTCTCTTCTCGGAGG	0.398													0	0	0	0.006122	0	19	57										G	35591979	C	G	35591979	3	3	128	1	0	0	0	0	1	0	0	0	106	922	32	1	4122	1	ACACA	17	35591979	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	633376	35591979	45603231	251	38290										
MED1	5469	broad.mit.edu	37	chr17	37599809	37599809	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagtgttcacaaacctttgaGagccttctgcaatgtctcca	7	11	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:37599809G>T	uc002hrv.3	-	3	417	c.205C>A	c.(205-207)CTC>ATC	p.L69I	MED1_uc010wee.1_5'UTR|MED1_uc002hru.2_Missense_Mutation_p.L69I	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	69	Interaction with ESR1.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		AAACCTTTGAGAGCCTTCTGC	0.398										HNSCC(31;0.082)			1	0	0.00448238	0.004482	0.00466866	8	49										T	37599809	G	T	37599809	3	4	128	1	0	0	0	0	1	0	0	0	9425	942	33	3	4600	3	MED1	17	37599809	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2007830	37599809	43595401	252	38291										
G6PC	2538	broad.mit.edu	37	chr17	41063350	41063350	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtcttctacgtcttgtccttCtgcaagagtgcggtagtgcc	11	11	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:41063350C>T	uc002icb.1	+	5	1060	c.981C>T	c.(979-981)TTC>TTT	p.F327F	G6PC_uc010whf.1_3'UTR	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	327	Helical; (Potential).		Missing (in GSD1A).		gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TCTTGTCCTTCTGCAAGAGTG	0.577									Glycogen_Storage_Disease_type_Ia				0	0	0	0.010729	0	10	117										T	41063350	C	T	41063350	2	4	128	1	0	0	0	0	0	0	0	1	6143	912	32	1		1	G6PC	17	41063350	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3463541	41063350	40131860	253	38292										
AARSD1	80755	broad.mit.edu	37	chr17	41105755	41105755	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcttacctctgacccaatctCattggcaatgatattcatga	5	11	4	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:41105755C>G	uc002icc.2	-	10	997	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	AARSD1_uc002icd.2_Missense_Mutation_p.E445Q|AARSD1_uc002ice.2_Missense_Mutation_p.E415Q|AARSD1_uc002icf.2_Missense_Mutation_p.E506Q|AARSD1_uc010whg.1_Missense_Mutation_p.E506Q	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	332					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GACCCAATCTCATTGGCAATG	0.502													0	0	0	0.00308	0	8	54										G	41105755	C	G	41105755	3	3	128	1	0	0	0	0	1	0	0	0	21	835	29	1	256	1	AARSD1	17	41105755	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	42405	41105755	40089455	254	38293										
BRCA1	672	broad.mit.edu	37	chr17	41203122	41203122	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cccatagcaacagatttctaGccccctgaagatctggaaga	8	12	2	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:41203122G>T	uc002icq.2	-	20	5522	c.5290C>A	c.(5290-5292)CTA>ATA	p.L1764I	BRCA1_uc010whp.1_Missense_Mutation_p.L613I|BRCA1_uc010whl.1_Missense_Mutation_p.L660I|BRCA1_uc010whm.1_Missense_Mutation_p.L74I|BRCA1_uc002icp.3_Missense_Mutation_p.L1693I|BRCA1_uc002icu.2_Missense_Mutation_p.L660I|BRCA1_uc010cyx.2_Missense_Mutation_p.L1717I|BRCA1_uc002ict.2_Missense_Mutation_p.L1785I|BRCA1_uc010whn.1_Missense_Mutation_p.L255I|BRCA1_uc010who.1_Intron	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1764	BRCT 2.		L -> P (in BC; unknown pathological significance).		androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CAGATTTCTAGCCCCCTGAAG	0.463			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			1	0	0.00307968	0.00308	0.00322442	8	40										T	41203122	G	T	41203122	3	4	128	1	0	0	0	0	1	0	0	0	1498	962	34	4	317	4	BRCA1	17	41203122	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	97367	41203122	39992088	255	38294										
IMP5	162540	broad.mit.edu	37	chr17	43923859	43923859	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agcctcttctggactggccaGggcagagctaagatgtgtgg	15	9	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:43923859G>A	uc010wka.1	+	1	1587	c.1587G>A	c.(1585-1587)CAG>CAA	p.Q529Q	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	529	Extracellular (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		GGACTGGCCAGGGCAGAGCTA	0.632													0	0	0	0.008291	0	11	55										A	43923859	G	A	43923859	2	1	128	1	0	0	0	0	0	0	0	1	7721	991	35	2		2	IMP5	17	43923859	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2720737	43923859	37271351	256	38295										
KIAA1267	284058	broad.mit.edu	37	chr17	44248783	44248783	+	Frame_Shift_Del	DEL	G	G	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgataatctactgcttccttGaagtgccggctgttccatgg					rs142096969	byFrequency	TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:44248783delG	uc002ikb.2	-	1	812	c.727delC	c.(727-729)CAAfs	p.Q243fs	KIAA1267_uc002ikc.2_Frame_Shift_Del_p.Q243fs|KIAA1267_uc002ikd.2_Frame_Shift_Del_p.Q243fs|KIAA1267_uc010dav.2_Frame_Shift_Del_p.Q243fs	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	243						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTGCTTCCTTGAAGTGCCGGC	0.438																		12	138	---	---								-	44248783	G	-	44248783	7	5	128	1	0	1	0	1	0	0	0	0	8219	1299	45	0	2646	0	KIAA1267	17	44248783	Frame_Shift_Del	DEL	G	TCGA-K4-A3WS-01A-11D-A22Z-08	324924	44248783	36946427	257	38296										
METTL2A	339175	broad.mit.edu	37	chr17	60501649	60501649	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtccaggagaacagtatccaGcgggtgtgccaggagaaaca	14	9	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:60501649G>T	uc002izv.2	+	2	198	c.180G>T	c.(178-180)CAG>CAT	p.Q60H	METTL2A_uc002izw.2_5'UTR	NM_181725	NP_859076	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	60							methyltransferase activity				0			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			ACAGTATCCAGCGGGTGTGCC	0.592											OREG0024635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.00024832	0.009096	0.000263429	3	30										T	60501649	G	T	60501649	3	4	128	1	0	0	0	0	1	0	0	0	9499	962	34	4	186	4	METTL2A	17	60501649	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	16252866	60501649	20693561	258	38297										
TLK2	11011	broad.mit.edu	37	chr17	60629727	60629727	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcattcctgcagctcccaaaAacagatctccatccagcaca	5	16	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:60629727A>G	uc010ddp.2	+	8	864	c.596A>G	c.(595-597)AAA>AGA	p.K199R	TLK2_uc002izx.3_Missense_Mutation_p.K47R|TLK2_uc002izz.3_Missense_Mutation_p.K199R|TLK2_uc002jaa.3_Missense_Mutation_p.K167R|TLK2_uc010wpd.1_Missense_Mutation_p.K167R	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	199					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						AGCTCCCAAAAACAGATCTCC	0.478													0	0	0	0.004482	0	5	25										G	60629727	A	G	60629727	3	3	128	1	0	0	0	0	1	0	0	0	15941	14	1	5	622	5	TLK2	17	60629727	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	128078	60629727	20565483	259	38298										
GNA13	10672	broad.mit.edu	37	chr17	63010911	63010911	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gatgcctttggtgggtcttcTggcaagcagaatatcttgtt	12	7	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:63010911T>C	uc002jfc.2	-	4	807	c.598A>G	c.(598-600)AGA>GGA	p.R200G	GNA13_uc010wqh.1_Missense_Mutation_p.R105G	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	200	GTP (By similarity).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						GTGGGTCTTCTGGCAAGCAGA	0.353													0	0	0	0.008871	0	19	49										C	63010911	T	C	63010911	3	2	128	1	0	0	0	0	1	0	0	0	6501	1588	55	5	539	5	GNA13	17	63010911	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	2381184	63010911	18184299	260	38299										
AMZ2	51321	broad.mit.edu	37	chr17	66247008	66247008	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggctactgtaaagcatatttCtatggcttgagagtaaaact	9	6	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:66247008C>G	uc002jgs.1	+	4	474	c.357C>G	c.(355-357)TTC>TTG	p.F119L	AMZ2_uc002jgr.1_Missense_Mutation_p.F119L|AMZ2_uc002jgt.1_Missense_Mutation_p.F119L|AMZ2_uc002jgu.1_Missense_Mutation_p.F119L|AMZ2_uc002jgv.1_Missense_Mutation_p.F119L|AMZ2_uc002jgw.1_Intron|AMZ2_uc002jgy.1_Missense_Mutation_p.F119L	NM_001033572	NP_001028744	Q86W34	AMZ2_HUMAN	archaemetzincins-2 isoform 1	119							metallopeptidase activity|zinc ion binding				0	all_cancers(12;1.12e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			AAGCATATTTCTATGGCTTGA	0.368													0	0	0	0.00308	0	8	59										G	66247008	C	G	66247008	3	3	128	1	0	0	0	0	1	0	0	0	597	912	32	1	363	1	AMZ2	17	66247008	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3236097	66247008	14948202	261	38300										
KCNJ16	3773	broad.mit.edu	37	chr17	68129040	68129055	+	Frame_Shift_Del	DEL	TAGCCAAAGATAACTT	TAGCCAAAGATAACTT	-													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgcccttgaccgcaaagcagTagccaaagataactttgaga							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:68129040_68129055delTAGCCAAAGATAACTT	uc002jin.2	+	5	1298_1313	c.812_827delTAGCCAAAGATAACTT	c.(811-828)GTAGCCAAAGATAACTTTfs	p.V271fs	KCNJ16_uc002jio.2_Frame_Shift_Del_p.V271fs|KCNJ16_uc002jip.2_Frame_Shift_Del_p.V271fs|KCNJ16_uc002jiq.2_Frame_Shift_Del_p.V303fs	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	271_276	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CGCAAAGCAGTAGCCAAAGATAACTTTGAGATTTTG	0.449																		10	139	---	---								-	68129055	TAGCCAAAGATAACTT	-	68129040	7	5	128	1	0	1	0	1	0	0	0	0	8050	1638	57	0	814	0	KCNJ16	17	68129040	Frame_Shift_Del	DEL	TAGCCAAAGATAACTT	TCGA-K4-A3WS-01A-11D-A22Z-08	1882032	68129040	13066170	262	38301										
C17orf77	146723	broad.mit.edu	37	chr17	72588357	72588358	+	Missense_Mutation	DNP	CC	CC	AG													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cacatggtcctgtctcctctCctctccttggtgatcacagg							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:72588357_72588358CC>AG	uc002jla.1	+	3	534_535	c.172_173CC>AG	c.(172-174)CCT>AGT	p.P58S	CD300LD_uc002jkz.2_5'UTR	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	58						extracellular region					0						TGTCTCCTCTCCTCTCCTTGGT	0.55													0	0	0	0.004672	0	11	52										AG	72588358	CC	AG	72588357	3	1	128	1	0	0	0	0	1	0	0	0	1882	855	30	3	174	3	C17orf77	17	72588357	Missense_Mutation	DNP	CC	TCGA-K4-A3WS-01A-11D-A22Z-08	4459317	72588357	8606853	263	38302										
USH1G	124590	broad.mit.edu	37	chr17	72915769	72915769	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggtctccagcgggctagtctCgggctccaggtcctcgtcca	13	15	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:72915769C>T	uc002jme.1	-	2	1345	c.1162G>A	c.(1162-1164)GAG>AAG	p.E388K	USH1G_uc010wro.1_Missense_Mutation_p.E285K	NM_173477	NP_775748	Q495M9	USH1G_HUMAN	Usher syndrome 1G protein	388	SAM.				equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton				skin(2)	2	all_lung(278;0.172)|Lung NSC(278;0.207)					GGGCTAGTCTCGGGCTCCAGG	0.632													0	0	0	0.00308	0	7	41										T	72915769	C	T	72915769	3	4	128	1	0	0	0	0	1	0	0	0	17032	893	31	1	231	1	USH1G	17	72915769	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	327412	72915769	8279441	264	38303										
CASKIN2	57513	broad.mit.edu	37	chr17	73498743	73498743	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcatccccctctgtggggccAgggcggcttaggctgtggga	17	12	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:73498743A>T	uc002joc.2	-	18	2962	c.2412T>A	c.(2410-2412)CCT>CCA	p.P804P	CASKIN2_uc010wsc.1_Silent_p.P722P	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	804	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGTGGGGCCAGGGCGGCTTA	0.711													0	0	0	0.004672	0	3	6										T	73498743	A	T	73498743	2	4	128	1	0	0	0	0	0	0	0	1	2667	175	7	5		5	CASKIN2	17	73498743	Silent	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	582974	73498743	7696467	265	38304										
UNK	85451	broad.mit.edu	37	chr17	73780818	73780818	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	taaaattccagccggacataGaaccacaactcccagcaacc	5	15	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:73780818G>A	uc002jpm.2	+	2	85	c.85G>A	c.(85-87)GAA>AAA	p.E29K	UNK_uc002jpn.2_RNA|UNK_uc002jpo.2_RNA	NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	Error:Variant_position_missing_in_Q9C0B0_after_alignment							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCGGACATAGAACCACAACT	0.637													0	0	0	0.004672	0	3	21										A	73780818	G	A	73780818	3	1	128	1	0	0	0	0	1	0	0	0	16997	943	33	1	91	1	UNK	17	73780818	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	282075	73780818	7414392	266	38305										
EVPL	2125	broad.mit.edu	37	chr17	74005731	74005731	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agctgcactttgggcctctgCttctccaccacgctgtactt	8	15	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:74005731C>T	uc002jqi.2	-	22	3783	c.3555G>A	c.(3553-3555)AAG>AAA	p.K1185K	EVPL_uc010wss.1_Silent_p.K1207K|EVPL_uc010wst.1_Silent_p.K655K	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1185	Central fibrous rod domain.|Plectin 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TGGGCCTCTGCTTCTCCACCA	0.632													0	0	0	0.009096	0	4	57										T	74005731	C	T	74005731	2	4	128	1	0	0	0	0	0	0	0	1	5292	796	28	2		2	EVPL	17	74005731	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	224913	74005731	7189479	267	38306										
THOC4	10189	broad.mit.edu	37	chr17	79846256	79846256	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctccaccaccaccaaaacctCcagcgccacggtttctagtc	5	19	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr17:79846256C>G	uc002kbu.2	-	5	647	c.641G>C	c.(640-642)GGA>GCA	p.G214A		NM_005782	NP_005773	Q86V81	THOC4_HUMAN	THO complex 4	207	Ala/Arg/Gly-rich.				intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			ACCAAAACCTCCAGCGCCACG	0.612													0	0	0	0.00308	0	8	15										G	79846256	C	G	79846256	3	3	128	1	0	0	0	0	1	0	0	0	15864	855	30	1	161	1	THOC4	17	79846256	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	5840525	79846256	1348954	268	38307										
LPIN2	9663	broad.mit.edu	37	chr18	2939525	2939525	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgtccactccatgtgagactCtgatctgagcaggctctccg	10	14	3	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr18:2939525C>T	uc002klo.2	-	6	1014	c.775G>A	c.(775-777)GAG>AAG	p.E259K		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	259					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		ATGTGAGACTCTGATCTGAGC	0.512													0	0	0	0.00623	0	41	36										T	2939525	C	T	2939525	3	4	128	1	0	0	0	0	1	0	0	0	8919	922	32	1	1975	1	LPIN2	18	2939525	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		2939525	75137723	269	38308										
SLC14A1	6563	broad.mit.edu	37	chr18	43319618	43319618	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggcaaacccacctcctggctCttggctgtggtgagtctccc	11	15	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr18:43319618C>T	uc010xcn.1	+	9	1256	c.937C>T	c.(937-939)CTT>TTT	p.L313F	SLC14A1_uc010dnk.2_Missense_Mutation_p.L369F|SLC14A1_uc002lbf.3_Missense_Mutation_p.L313F|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.L208F|SLC14A1_uc002lbh.3_Missense_Mutation_p.L205F|SLC14A1_uc002lbi.3_Missense_Mutation_p.L181F|SLC14A1_uc002lbj.3_Missense_Mutation_p.L369F|SLC14A1_uc002lbk.3_Missense_Mutation_p.L313F	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	313	Helical; (Potential).					integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						CCTCCTGGCTCTTGGCTGTGG	0.468													0	0	0	0.004482	0	9	35										T	43319618	C	T	43319618	3	4	128	1	0	0	0	0	1	0	0	0	14396	913	32	1	1131	1	SLC14A1	18	43319618	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	40380093	43319618	34757630	270	38309										
ELANE	1991	broad.mit.edu	37	chr19	855684	855684	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggggccttctgggcaggaacCgtgggatcgccagcgtcctg	17	12	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:855684C>T	uc002lqb.2	+	4	525	c.487C>T	c.(487-489)CGT>TGT	p.R163C		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	163	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	GGGCAGGAACCGTGGGATCGC	0.706									Kostmann_syndrome				0	0	0	0.010729	0	10	50										T	855684	C	T	855684	3	4	128	1	0	0	0	0	1	0	0	0	5048	652	23	2	501	2	ELANE	19	855684	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		855684	58273299	271	38310										
C19orf28	126321	broad.mit.edu	37	chr19	3548011	3548011	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aacacggcgccgacacccacCaccagcagggacaggttctg	11	16	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:3548011C>A	uc002lxz.2	-	4	842	c.672G>T	c.(670-672)GTG>GTT	p.V224V	C19orf28_uc002lxw.2_Silent_p.V224V|C19orf28_uc002lxx.2_Silent_p.V224V|C19orf28_uc002lxy.2_Silent_p.V215V	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	224	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CGACACCCACCACCAGCAGGG	0.701													1	0	0.004672	0.004672	0.00484101	3	23										A	3548011	C	A	3548011	2	1	128	1	0	0	0	0	0	0	0	1	1917	581	21	4		4	C19orf28	19	3548011	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2692327	3548011	55580972	272	38311										
DNM2	1785	broad.mit.edu	37	chr19	10883223	10883223	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgaagtccggcaggagattGaagcagagaccgacagggtc	15	8	0	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:10883223G>A	uc002mps.1	+	3	468	c.304G>A	c.(304-306)GAA>AAA	p.E102K	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Missense_Mutation_p.E102K|DNM2_uc002mpv.1_Missense_Mutation_p.E102K|DNM2_uc002mpu.1_Missense_Mutation_p.E102K|DNM2_uc010dxl.1_Missense_Mutation_p.E102K	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	102					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GCAGGAGATTGAAGCAGAGAC	0.522													0	0	0	0.001855	0	13	90										A	10883223	G	A	10883223	3	1	128	1	0	0	0	0	1	0	0	0	4672	1291	45	1	314	1	DNM2	19	10883223	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	7335212	10883223	48245760	273	38312										
ZNF709	163051	broad.mit.edu	37	chr19	12595589	12595589	+	Translation_Start_Site	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tctggggtgaggagaccccaGagcggagcgcagcggctggt	19	10	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:12595589G>T	uc002mtv.3	-	1	44	c.-117C>A	c.(-119--115)CTCTG>CTATG		ZNF709_uc002mtw.3_Intron|ZNF709_uc002mtx.3_Intron	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGACCCCAGAGCGGAGCGC	0.682													1	0	0.004672	0.004672	0.00484101	3	17										T	12595589	G	T	12595589	1	4	128	1	0	0	0	0	0	0	0	0	18110	957	33	3		3	ZNF709	19	12595589	Translation_Start_Site	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1712366	12595589	46533394	274	38313										
CC2D1A	54862	broad.mit.edu	37	chr19	14037643	14037643	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tctggtcataggaagaagctCagaaagacaagaccagtgtg	12	7	3	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:14037643C>G	uc002mxo.2	+	20	2382	c.2083C>G	c.(2083-2085)CAG>GAG	p.Q695E	CC2D1A_uc002mxp.2_Missense_Mutation_p.Q695E|CC2D1A_uc010dzh.2_Missense_Mutation_p.Q264E|CC2D1A_uc002mxq.1_Missense_Mutation_p.Q340E	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	695	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GGAAGAAGCTCAGAAAGACAA	0.587													0	0	0	0.001855	0	14	46										G	14037643	C	G	14037643	3	3	128	1	0	0	0	0	1	0	0	0	2726	827	29	1	2161	1	CC2D1A	19	14037643	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1442054	14037643	45091340	275	38314										
OR7C1	26664	broad.mit.edu	37	chr19	14910225	14910225	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaccactgagaggtgggaacCacaggtggaaaacgctttgt	14	8	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:14910225C>T	uc010xnz.1	-	1	724	c.724G>A	c.(724-726)GGT>AGT	p.G242S		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	242	Helical; Name=6; (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						AGGTGGGAACCACAGGTGGAA	0.463													0	0	0	0.004482	0	9	78										T	14910225	C	T	14910225	3	4	128	1	0	0	0	0	1	0	0	0	11217	594	21	2	240	2	OR7C1	19	14910225	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	872582	14910225	44218758	276	38315										
CALR3	125972	broad.mit.edu	37	chr19	16601209	16601209	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tagtactgcgattttccattCaggttcttctggtcaatgtc	8	9	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:16601209C>T	uc002ned.2	-	3	429	c.366G>A	c.(364-366)CTG>CTA	p.L122L	MED26_uc002nee.2_Intron	NM_145046	NP_659483	Q96L12	CALR3_HUMAN	calreticulin 3 precursor	122	N-domain.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0						ATTTTCCATTCAGGTTCTTCT	0.423													0	0	0	0.007291	0	26	55										T	16601209	C	T	16601209	2	4	128	1	0	0	0	0	0	0	0	1	2593	813	29	1		1	CALR3	19	16601209	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1690984	16601209	42527774	277	38316										
C19orf62	29086	broad.mit.edu	37	chr19	17382464	17382464	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aaagctggagtcgttcaacgGgtaagagggacattttaggg	15	5	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:17382464G>C	uc002nfu.2	+	3	462	c.344G>C	c.(343-345)GGC>GCC	p.G115A	C19orf62_uc010xpl.1_Missense_Mutation_p.G115A|C19orf62_uc002nfv.2_Missense_Mutation_p.G115A|C19orf62_uc010ean.2_Intron|C19orf62_uc002nfw.2_Missense_Mutation_p.G115A	NM_014173	NP_054892	Q9NWV8	BABA1_HUMAN	mediator of Rap80 interactions and targeting 40	115	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding	p.G115V(1)		ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2						TCGTTCAACGGGTAAGAGGGA	0.532													0	0	0	0.009096	0	3	18										C	17382464	G	C	17382464	3	2	128	1	0	0	0	0	1	0	0	0	1944	1246	43	4	350	4	C19orf62	19	17382464	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	781255	17382464	41746519	278	38317										
NCAN	1463	broad.mit.edu	37	chr19	19339266	19339266	+	Nonsense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgagtctgcctcagtttcctCaggggagcctacggtaccgt	12	13	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:19339266C>G	uc002nlz.2	+	8	2936	c.2837C>G	c.(2836-2838)TCA>TGA	p.S946*	NCAN_uc010ecc.1_Nonsense_Mutation_p.S510*	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	946					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TCAGTTTCCTCAGGGGAGCCT	0.647													0	0	0	0.004007	0	16	131										G	19339266	C	G	19339266	4	3	128	1	0	0	0	0	0	1	0	0	10204	838	29	1	2863	1	NCAN	19	19339266	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1956802	19339266	39789717	279	38318										
ZNF43	7594	broad.mit.edu	37	chr19	21992472	21992472	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcctctgtgcaccttacactCatccacacttttatggtctt	4	14	3	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:21992472C>T	uc002nqj.2	-	4	497	c.367G>A	c.(367-369)GAG>AAG	p.E123K	ZNF43_uc010ecv.2_Missense_Mutation_p.E117K|ZNF43_uc002nql.2_Missense_Mutation_p.E117K|ZNF43_uc002nqm.2_Missense_Mutation_p.E117K|ZNF43_uc002nqk.2_Missense_Mutation_p.E53K	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		ACCTTACACTCATCCACACTT	0.338													0	0	0	0.001168	0	6	110										T	21992472	C	T	21992472	3	4	128	1	0	0	0	0	1	0	0	0	17900	835	29	1	2066	1	ZNF43	19	21992472	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2653206	21992472	37136511	280	38319										
ANKRD27	84079	broad.mit.edu	37	chr19	33110200	33110200	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcttggtctcctcctgccttGagctggctgacatggaggag	13	11	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:33110200G>A	uc002ntn.1	-	20	2129	c.1973C>T	c.(1972-1974)TCA>TTA	p.S658L		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	658					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					CTCCTGCCTTGAGCTGGCTGA	0.642													0	0	0	0.006214	0	7	102										A	33110200	G	A	33110200	3	1	128	1	0	0	0	0	1	0	0	0	655	1294	45	1	1219	1	ANKRD27	19	33110200	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	11117728	33110200	26018783	281	38320										
KIAA0355	9710	broad.mit.edu	37	chr19	34818975	34818975	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atgcagtgtgagctccccacCgtccctgtgcagataggatc	11	13	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:34818975C>G	uc002nvd.3	+	6	1882	c.1023C>G	c.(1021-1023)ACC>ACG	p.T341T		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	341										ovary(1)	1	Esophageal squamous(110;0.162)					AGCTCCCCACCGTCCCTGTGC	0.607													0	0	0	0.006122	0	18	91										G	34818975	C	G	34818975	2	3	128	1	0	0	0	0	0	0	0	1	8170	639	23	4		4	KIAA0355	19	34818975	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1708775	34818975	24310008	282	38321										
ZNF146	7705	broad.mit.edu	37	chr19	36727883	36727883	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atcagaacattcacactggaGagaaaccctatgaatgtaac	7	9	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:36727883G>C	uc002odq.3	+	4	2064	c.541G>C	c.(541-543)GAG>CAG	p.E181Q	ZNF146_uc010eet.2_Missense_Mutation_p.E181Q|ZNF146_uc010eeu.2_Missense_Mutation_p.E181Q	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	181					regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TCACACTGGAGAGAAACCCTA	0.393													0	0	0	0.01441	0	57	59										C	36727883	G	C	36727883	3	2	128	1	0	0	0	0	1	0	0	0	17730	943	33	1	543	1	ZNF146	19	36727883	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1908908	36727883	22401100	283	38322										
ZNF607	84775	broad.mit.edu	37	chr19	38189439	38189439	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	catttgttgcattcaaagggTttcttaccactgtgaatact	7	8	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:38189439T>G	uc002ohc.1	-	5	2189	c.1593A>C	c.(1591-1593)AGA>AGC	p.R531S	ZNF607_uc002ohb.1_Missense_Mutation_p.K530N	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	531					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			ATTCAAAGGGTTTCTTACCAC	0.403													0	0	0	0.01441	0	62	80										G	38189439	T	G	38189439	3	3	128	1	0	0	0	0	1	0	0	0	18030	1722	60	5	501	5	ZNF607	19	38189439	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	1461556	38189439	20939544	284	38323										
SAMD4B	55095	broad.mit.edu	37	chr19	39866329	39866329	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccctagcccactgaagcgctCcatgtcactcatccctacaa	5	18	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:39866329C>G	uc002olb.2	+	7	1742	c.707C>G	c.(706-708)TCC>TGC	p.S236C	SAMD4B_uc002ola.2_Missense_Mutation_p.S236C	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	236							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CTGAAGCGCTCCATGTCACTC	0.602													0	0	0	0.012319	0	23	244										G	39866329	C	G	39866329	3	3	128	1	0	0	0	0	1	0	0	0	13822	855	30	1	717	1	SAMD4B	19	39866329	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1676890	39866329	19262654	285	38324										
SAMD4B	55095	broad.mit.edu	37	chr19	39868426	39868426	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cccggctcccgtcgccgacgGagacatccccagccagttta	10	18	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:39868426G>A	uc002olb.2	+	10	2441	c.1406G>A	c.(1405-1407)GGA>GAA	p.G469E	SAMD4B_uc002ola.2_Missense_Mutation_p.G469E	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	469							protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GTCGCCGACGGAGACATCCCC	0.622													0	0	0	0.009096	0	4	52										A	39868426	G	A	39868426	3	1	128	1	0	0	0	0	1	0	0	0	13822	1174	41	1	1428	1	SAMD4B	19	39868426	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	2097	39868426	19260557	286	38325										
TIMM50	92609	broad.mit.edu	37	chr19	39976916	39976916	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tatgaaattgtcatctttacGtcagagactggcatggtgag	11	6	3	3	rs62120692		TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:39976916G>A	uc002olu.1	+	7	1024	c.891G>A	c.(889-891)ACG>ACA	p.T297T	TIMM50_uc002olt.1_RNA|TIMM50_uc002olv.1_5'UTR	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	194	Mitochondrial intermembrane (Potential).|FCP1 homology.				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCATCTTTACGTCAGAGACTG	0.552													0	0	0	0.009535	0	31	225										A	39976916	G	A	39976916	2	1	128	1	0	0	0	0	0	0	0	1	15910	1132	40	2		2	TIMM50	19	39976916	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	108490	39976916	19152067	287	38326										
CEACAM7	1087	broad.mit.edu	37	chr19	42192066	42192066	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cctgccagggaatgcacactCtgtatggacaggctgaaggg	14	10	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:42192066C>G	uc002ori.1	-	1	31	c.29G>C	c.(28-30)AGA>ACA	p.R10T	CEACAM7_uc010ehx.2_Missense_Mutation_p.R10T|CEACAM7_uc010ehy.1_Missense_Mutation_p.R10T	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	10						anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		AATGCACACTCTGTATGGACA	0.617													0	0	0	0.00245	0	14	44										G	42192066	C	G	42192066	3	3	128	1	0	0	0	0	1	0	0	0	3197	913	32	1	784	1	CEACAM7	19	42192066	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2215150	42192066	16936917	288	38327										
ZNF223	7766	broad.mit.edu	37	chr19	44571048	44571048	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgggaagagcttcagacggtCctcctatcttttgatccatc	9	11	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:44571048C>T	uc002oyf.1	+	5	1320	c.1067C>T	c.(1066-1068)TCC>TTC	p.S356F	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	356	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TTCAGACGGTCCTCCTATCTT	0.438													0	0	0	0.001984	0	7	139										T	44571048	C	T	44571048	3	4	128	1	0	0	0	0	1	0	0	0	17774	855	30	1	1081	1	ZNF223	19	44571048	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2378982	44571048	14557935	289	38328										
CCDC9	26093	broad.mit.edu	37	chr19	47773894	47773894	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agctgaggccagcagccgcaGaaggagaaagagcagtcggc	16	10	0	4			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:47773894G>C	uc010xym.1	+	10	1241	c.1034G>C	c.(1033-1035)AGA>ACA	p.R345T		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	345	Poly-Arg.										0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		AGCAGCCGCAGAAGGAGAAAG	0.672													0	0	0	0.000602	0	5	49										C	47773894	G	C	47773894	3	2	128	1	0	0	0	0	1	0	0	0	2867	942	33	1	1068	1	CCDC9	19	47773894	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3202846	47773894	11355089	290	38329										
PNKP	11284	broad.mit.edu	37	chr19	50370408	50370408	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ggcaggaagatggggggcgcTcccccaggggggctctcgag	20	11	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:50370408T>C	uc002pqh.2	-	1	106	c.54A>G	c.(52-54)GGA>GGG	p.G18G	PNKP_uc002pqg.2_5'Flank|PNKP_uc002pqi.2_5'UTR|PNKP_uc002pqj.2_Silent_p.G18G|PNKP_uc010enm.2_Silent_p.G18G|PNKP_uc002pqk.2_Silent_p.G18G	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	18				G -> E (in Ref. 1; AAD51135).	DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TGGGGGGCGCTCCCCCAGGGG	0.711								Other_BER_factors					0	0	0	0.010729	0	10	22										C	50370408	T	C	50370408	2	2	128	1	0	0	0	0	0	0	0	1	12147	1538	54	5		5	PNKP	19	50370408	Silent	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	2596514	50370408	8758575	291	38330										
MYBPC2	4606	broad.mit.edu	37	chr19	50947074	50947074	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gagggtgcccaggtgatgtgGtaagtgacccttgatccctg	15	9	0	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:50947074G>A	uc002psf.2	+	11	1184	c.1133_splice	c.e11+1	p.W378_splice		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type						cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		AGGTGATGTGGTAAGTGACCC	0.512													0	0	0	0.01441	0	50	61										A	50947074	G	A	50947074	5	1	128	1	0	0	0	0	0	0	1	0	10012	1275	44	2	1176	2	MYBPC2	19	50947074	Splice_Site	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	576666	50947074	8181909	292	38331										
CD33	945	broad.mit.edu	37	chr19	51728804	51728804	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cttctttcggatggagagagGaagtaccaaatacagttaca	10	7	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:51728804G>T	uc002pwa.2	+	2	408	c.368G>T	c.(367-369)GGA>GTA	p.G123V	CD33_uc010eos.1_Missense_Mutation_p.G123V|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	123	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	ATGGAGAGAGGAAGTACCAAA	0.527													1	0	2.27111e-07	0.013537	2.55102e-07	13	52										T	51728804	G	T	51728804	3	4	128	1	0	0	0	0	1	0	0	0	3005	1174	41	3	374	3	CD33	19	51728804	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	781730	51728804	7400179	293	38332										
ZSCAN5B	342933	broad.mit.edu	37	chr19	56701308	56701308	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcttctctccggagtgggtgCgctggtgaacgttcaggttc	15	10	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:56701308C>T	uc010ygh.1	-	4	1376	c.1376G>A	c.(1375-1377)CGC>CAC	p.R459H		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	459	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGAGTGGGTGCGCTGGTGAAC	0.537													0	0	0	0.00278	0	25	24										T	56701308	C	T	56701308	3	4	128	1	0	0	0	0	1	0	0	0	18236	768	27	2	115	2	ZSCAN5B	19	56701308	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	4972504	56701308	2427675	294	38333										
PEG3	5178	broad.mit.edu	37	chr19	57335683	57335683	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcagagtgacgagcttctcaCagttctccggcttttttgct	10	11	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr19:57335683C>G	uc002qnu.2	-	1	692	c.341G>C	c.(340-342)TGT>TCT	p.C114S	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Missense_Mutation_p.C114S|PEG3_uc002qnv.2_Missense_Mutation_p.C114S|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Missense_Mutation_p.C114S	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	114	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GAGCTTCTCACAGTTCTCCGG	0.532													0	0	0	0.001984	0	7	94										G	57335683	C	G	57335683	3	3	128	1	0	0	0	0	1	0	0	0	11720	478	17	4		4	PEG3	19	57335683	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	634375	57335683	1793300	295	38334										
VPS16	64601	broad.mit.edu	37	chr20	2842542	2842542	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acgagttcctgcatgaggttCcaggtgaggccttcacaagg	13	10	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:2842542C>A	uc002whe.2	+	10	1039	c.991C>A	c.(991-993)CCA>ACA	p.P331T	VPS16_uc002whh.2_5'Flank|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Intron|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank|VPS16_uc002whi.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	331					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						GCATGAGGTTCCAGGTGAGGC	0.612													1	0	5.18039e-06	0.00308	5.69133e-06	7	22										A	2842542	C	A	2842542	3	1	128	1	0	0	0	0	1	0	0	0	17190	855	30	3	1029	3	VPS16	20	2842542	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		2842542	60182978	296	38335										
C20orf103	24141	broad.mit.edu	37	chr20	9496203	9496203	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtgcgggaaaatgggacgacGtgtctcatggcagagtttgc	16	7	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:9496203G>C	uc002wni.1	+	2	397	c.168G>C	c.(166-168)ACG>ACC	p.T56T	C20orf103_uc010zrc.1_Silent_p.T56T	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	56	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			ATGGGACGACGTGTCTCATGG	0.458													0	0	0	0.010729	0	12	112										C	9496203	G	C	9496203	2	2	128	1	0	0	0	0	0	0	0	1	2075	1132	40	4		4	C20orf103	20	9496203	Silent	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	6653661	9496203	53529317	297	38336										
ANKRD5	63926	broad.mit.edu	37	chr20	10030184	10030184	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	caggagccaaaaatccaaatCcactgtgggcccttagactg	9	12	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:10030184C>G	uc002wno.2	+	7	1360	c.967C>G	c.(967-969)CCA>GCA	p.P323A	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.P323A|ANKRD5_uc010gbz.2_Missense_Mutation_p.P134A	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	323							calcium ion binding			ovary(1)|breast(1)	2						AAATCCAAATCCACTGTGGGC	0.517													0	0	0	0.001984	0	7	80										G	10030184	C	G	10030184	3	3	128	1	0	0	0	0	1	0	0	0	676	855	30	1	985	1	ANKRD5	20	10030184	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	533981	10030184	52995336	298	38337										
RIN2	54453	broad.mit.edu	37	chr20	19977359	19977359	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aagcgcatatggagcactttCtctgataaagaatttccaag	8	8	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:19977359C>G	uc002wro.1	+	10	2273	c.2237C>G	c.(2236-2238)TCT>TGT	p.S746C	RIN2_uc010gcu.1_Missense_Mutation_p.S313C|RIN2_uc010gcv.1_Missense_Mutation_p.S540C	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	746	VPS9.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						GGAGCACTTTCTCTGATAAAG	0.527													0	0	0	0.000602	0	5	28										G	19977359	C	G	19977359	3	3	128	1	0	0	0	0	1	0	0	0	13372	913	32	1	2275	1	RIN2	20	19977359	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	9947175	19977359	43048161	299	38338										
NINL	22981	broad.mit.edu	37	chr20	25484683	25484683	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gaggccaagctggaattcctCaagactcactttgccgtctc	9	13	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:25484683C>T	uc002wux.1	-	7	840	c.766G>A	c.(766-768)GAG>AAG	p.E256K	NINL_uc010gdn.1_Missense_Mutation_p.E256K|NINL_uc010gdo.1_Missense_Mutation_p.E96K|NINL_uc010ztf.1_Missense_Mutation_p.E272K	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	256	Potential.|EF-hand 4.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TGGAATTCCTCAAGACTCACT	0.498													0	0	0	0.009535	0	33	113										T	25484683	C	T	25484683	3	4	128	1	0	0	0	0	1	0	0	0	10420	835	29	1	3454	1	NINL	20	25484683	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	5507324	25484683	37540837	300	38339										
MYLK2	85366	broad.mit.edu	37	chr20	30419638	30419638	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gccaaagactttgtctccaaCctcatcgtcaaggaccagag	8	13	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:30419638C>T	uc002wwq.2	+	11	1659	c.1557C>T	c.(1555-1557)AAC>AAT	p.N519N	MYLK2_uc002wws.2_Silent_p.N136N|MYLK2_uc010gdw.1_RNA	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	519	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTGTCTCCAACCTCATCGTCA	0.517													0	0	0	0.00308	0	7	75										T	30419638	C	T	30419638	2	4	128	1	0	0	0	0	0	0	0	1	10057	506	18	2		2	MYLK2	20	30419638	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	4934955	30419638	32605882	301	38340										
MYLK2	85366	broad.mit.edu	37	chr20	30419888	30419888	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gccaaacgctgtaaccgacgCcttaagtcccagatcttgct	8	14	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:30419888C>T	uc002wwq.2	+	12	1761	c.1659C>T	c.(1657-1659)CGC>CGT	p.R553R	MYLK2_uc002wws.2_Silent_p.R170R|MYLK2_uc010gdw.1_RNA	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	553					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTAACCGACGCCTTAAGTCCC	0.592													0	0	0	0.001984	0	7	12										T	30419888	C	T	30419888	2	4	128	1	0	0	0	0	0	0	0	1	10057	726	26	2		2	MYLK2	20	30419888	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	250	30419888	32605632	302	38341										
SUN5	140732	broad.mit.edu	37	chr20	31573573	31573573	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agtccttgggggcggtgtccAggctgcctgacaatgagatg	16	9	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:31573573A>T	uc002wyi.2	-	11	959	c.866T>A	c.(865-867)CTG>CAG	p.L289Q		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	289	SUN.				spermatogenesis					skin(1)	1						GGCGGTGTCCAGGCTGCCTGA	0.562													0	0	0	0.009096	0	4	40										T	31573573	A	T	31573573	3	4	128	1	0	0	0	0	1	0	0	0	15391	188	7	5	285	5	SUN5	20	31573573	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	1153685	31573573	31451947	303	38342										
C20orf185	359710	broad.mit.edu	37	chr20	31644371	31644371	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tccagaactcactggttgggGagcccattctgcagaatgtg	12	10	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:31644371G>A	uc002wym.1	+	2	148	c.148G>A	c.(148-150)GAG>AAG	p.E50K		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	50	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						ACTGGTTGGGGAGCCCATTCT	0.607													0	0	0	0.00874	0	43	73										A	31644371	G	A	31644371	3	1	128	1	0	0	0	0	1	0	0	0	2097	1175	41	1	154	1	C20orf185	20	31644371	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	70798	31644371	31381149	304	38343										
DLGAP4	22839	broad.mit.edu	37	chr20	35064619	35064619	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgcatgcgcagcggcagctaCatcaaggccatgggcgacga	14	13	1	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:35064619C>T	uc002xff.2	+	4	1542	c.1107C>T	c.(1105-1107)TAC>TAT	p.Y369Y	DLGAP4_uc010zvp.1_Silent_p.Y369Y	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	369					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GCGGCAGCTACATCAAGGCCA	0.736													0	0	0	0.004672	0	3	11										T	35064619	C	T	35064619	2	4	128	1	0	0	0	0	0	0	0	1	4562	489	17	2		2	DLGAP4	20	35064619	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3420248	35064619	27960901	305	38344										
KIAA0406	9675	broad.mit.edu	37	chr20	36641207	36641207	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	actctcatcatttactagtcCcactaaggccttcagaaggg	7	12	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:36641207C>A	uc002xhl.2	-	3	1221	c.1012G>T	c.(1012-1014)GGA>TGA	p.G338*	KIAA0406_uc002xhm.2_Nonsense_Mutation_p.G338*	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	338							binding				0		Myeloproliferative disorder(115;0.00874)				TTTACTAGTCCCACTAAGGCC	0.468													1	0	4.22769e-11	0.00632	4.95703e-11	28	170										A	36641207	C	A	36641207	4	1	128	1	0	0	0	0	0	1	0	0	8173	632	22	4	2285	4	KIAA0406	20	36641207	Nonsense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1576588	36641207	26384313	306	38345										
CHD6	84181	broad.mit.edu	37	chr20	40049171	40049171	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gactatggcagtttccgtctCtatcataatcatctttattc	5	10	4	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:40049171C>G	uc002xka.1	-	31	6282	c.6104G>C	c.(6103-6105)AGA>ACA	p.R2035T		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2035					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GTTTCCGTCTCTATCATAATC	0.433													0	0	0	0.006122	0	18	89										G	40049171	C	G	40049171	3	3	128	1	0	0	0	0	1	0	0	0	3329	913	32	1	2071	1	CHD6	20	40049171	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3407964	40049171	22976349	307	38346										
CHD6	84181	broad.mit.edu	37	chr20	40052303	40052303	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aacaacaccaaaggaagacaCtgttctatagaagtctgctt	7	9	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:40052303C>T	uc002xka.1	-	30	4562	c.4384G>A	c.(4384-4386)GTG>ATG	p.V1462M		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1462					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				AAGGAAGACACTGTTCTATAG	0.408													0	0	0	0.013537	0	12	167										T	40052303	C	T	40052303	3	4	128	1	0	0	0	0	1	0	0	0	3329	565	20	2	3795	2	CHD6	20	40052303	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	3132	40052303	22973217	308	38347										
SEMG2	6407	broad.mit.edu	37	chr20	43851768	43851768	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gcagtatttctttccaaattGaaaagctagtagaaggcaag	9	6	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:43851768G>A	uc010ggz.2	+	2	1552	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K	SEMG2_uc002xnk.2_Missense_Mutation_p.E499K|SEMG2_uc002xnl.2_Intron	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	499	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				TTTCCAAATTGAAAAGCTAGT	0.398													0	0	0	0.001168	0	6	77										A	43851768	G	A	43851768	3	1	128	1	0	0	0	0	1	0	0	0	14045	1291	45	1	1501	1	SEMG2	20	43851768	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3799465	43851768	19173752	309	38348										
WFDC13	164237	broad.mit.edu	37	chr20	44330835	44330835	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	agctggtgcctgggagtcccAagcagcgtgttctgagtagg	16	9	1	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:44330835A>C	uc002xpd.2	+	1	181	c.73A>C	c.(73-75)AAG>CAG	p.K25Q	WFDC10B_uc002xpb.2_Intron|WFDC10B_uc002xpc.2_Intron	NM_172005	NP_742002	Q8IUB5	WFD13_HUMAN	WAP four-disulfide core domain 13 precursor	25						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				TGGGAGTCCCAAGCAGCGTGT	0.562													0	0	0	0.009096	0	4	22										C	44330835	A	C	44330835	3	2	128	1	0	0	0	0	1	0	0	0	17348	131	5	5	75	5	WFDC13	20	44330835	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	479067	44330835	18694685	310	38349										
PCIF1	63935	broad.mit.edu	37	chr20	44574444	44574444	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cccatgcccagcgtggagatGcacatggagaacaacgtggt	13	11	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:44574444G>C	uc002xqs.2	+	12	1577	c.1263G>C	c.(1261-1263)ATG>ATC	p.M421I	PCIF1_uc002xqt.2_Missense_Mutation_p.M1I|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	421						nucleus				skin(1)	1						GCGTGGAGATGCACATGGAGA	0.612													0	0	0	0.006214	0	9	105										C	44574444	G	C	44574444	3	2	128	1	0	0	0	0	1	0	0	0	11580	1319	46	4	1301	4	PCIF1	20	44574444	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	243609	44574444	18451076	311	38350										
KCNB1	3745	broad.mit.edu	37	chr20	47990502	47990502	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcttggccatcttattgtacAtgtcttccaactgctgaacg	7	11	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:47990502A>C	uc002xur.1	-	2	1759	c.1595T>G	c.(1594-1596)ATG>AGG	p.M532R	KCNB1_uc002xus.1_Missense_Mutation_p.M532R	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	532	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTTATTGTACATGTCTTCCAA	0.468													0	0	0	0.00499	0	18	201										C	47990502	A	C	47990502	3	2	128	1	0	0	0	0	1	0	0	0	8012	217	8	5	985	5	KCNB1	20	47990502	Missense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	3416058	47990502	15035018	312	38351										
BCAS4	55653	broad.mit.edu	37	chr20	49493030	49493030	+	Silent	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cttgtcattccagaagtcacCtgcaccggtgcccgtgacgt	10	14	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:49493030C>G	uc002xvq.2	+	6	658	c.594C>G	c.(592-594)ACC>ACG	p.T198T	BCAS4_uc002xvr.2_Missense_Mutation_p.P166R|BCAS4_uc002xvs.2_Missense_Mutation_p.P121R	NM_017843	NP_060313	Q8TDM0	BCAS4_HUMAN	breast carcinoma amplified sequence 4 isoform a	198						cytoplasm					0						CAGAAGTCACCTGCACCGGTG	0.557													0	0	0	0.004007	0	16	107										G	49493030	C	G	49493030	2	3	128	1	0	0	0	0	0	0	0	1	1353	681	24	4		4	BCAS4	20	49493030	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	1502528	49493030	13532490	313	38352										
UCKL1	54963	broad.mit.edu	37	chr20	62575994	62575994	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtactgcttgatgacaccctCgatgtcccggccgcgctcac	10	16	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr20:62575994C>T	uc010gkn.2	-	6	791	c.748G>A	c.(748-750)GAG>AAG	p.E250K	UCKL1_uc002yhj.2_5'Flank|UCKL1_uc011abm.1_Missense_Mutation_p.E235K|UCKL1_uc011abn.1_RNA|UCKL1_uc011abo.1_RNA|MIR647_hsa-mir-647|MI0003662_5'Flank	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	250					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ATGACACCCTCGATGTCCCGG	0.602													0	0	0	0.001984	0	6	29										T	62575994	C	T	62575994	3	4	128	1	0	0	0	0	1	0	0	0	16922	893	31	1	938	1	UCKL1	20	62575994	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	13082964	62575994	449526	314	38353										
ADAMTS5	11096	broad.mit.edu	37	chr21	28304481	28304481	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atttttggcctcacactgttCatgacgaaatgatttaccta	6	9	2	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr21:28304481C>T	uc002ymg.2	-	6	2620	c.1891G>A	c.(1891-1893)GAA>AAA	p.E631K		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	631	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TCACACTGTTCATGACGAAAT	0.363													0	0	0	0.001984	0	7	37										T	28304481	C	T	28304481	3	4	128	1	0	0	0	0	1	0	0	0	269	835	29	1	913	1	ADAMTS5	21	28304481	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		28304481	19825414	315	38354										
KRTAP27-1	643812	broad.mit.edu	37	chr21	31709409	31709409	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cagtaacacagcaagttggtTcaactcctggagaagattcc	9	10	1	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr21:31709409T>C	uc002ynx.1	-	1	604	c.578A>G	c.(577-579)GAA>GGA	p.E193G		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	193						intermediate filament				ovary(2)	2						GCAAGTTGGTTCAACTCCTGG	0.438													0	0	0	0.00308	0	8	52										C	31709409	T	C	31709409	3	2	128	1	0	0	0	0	1	0	0	0	8544	1783	62	5	49	5	KRTAP27-1	21	31709409	Missense_Mutation	SNP	T	TCGA-K4-A3WS-01A-11D-A22Z-08	3404928	31709409	16420486	316	38355										
SIM2	6493	broad.mit.edu	37	chr21	38098555	38098555	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtgccatcaccgagatcaagCtgtacagtaacatgttcatg	9	10	3	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr21:38098555C>T	uc002yvr.2	+	6	735	c.679C>T	c.(679-681)CTG>TTG	p.L227L	SIM2_uc002yvq.2_Silent_p.L227L	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	227	PAS 2.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						CGAGATCAAGCTGTACAGTAA	0.567													0	0	0	0.00308	0	7	40										T	38098555	C	T	38098555	2	4	128	1	0	0	0	0	0	0	0	1	14324	796	28	2		2	SIM2	21	38098555	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	6389146	38098555	10031340	317	38356										
MCM3AP	8888	broad.mit.edu	37	chr21	47695171	47695171	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ccgcatgtacctctccttctCaggacacatatccaggcagg	8	15	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr21:47695171C>G	uc002zir.1	-	6	1963	c.1927G>C	c.(1927-1929)GAG>CAG	p.E643Q		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	643					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CTCTCCTTCTCAGGACACATA	0.537													0	0	0	0.000602	0	5	17										G	47695171	C	G	47695171	3	3	128	1	0	0	0	0	1	0	0	0	9388	835	29	1	4107	1	MCM3AP	21	47695171	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	9596616	47695171	434724	318	38357										
CLDN5	7122	broad.mit.edu	37	chr22	19511148	19511148	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtagttcttcttgtcgtagtCgccggtggccgtgggccgcc	15	12	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:19511148C>T	uc002zpu.2	-	2	1101	c.886G>A	c.(886-888)GAC>AAC	p.D296N	CLDN5_uc010grr.2_Missense_Mutation_p.D296N	NM_003277	NP_003268	O00501	CLD5_HUMAN	claudin 5	211	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0	Colorectal(54;0.0993)					TTGTCGTAGTCGCCGGTGGCC	0.716													0	0	0	0.009096	0	4	29										T	19511148	C	T	19511148	3	4	128	1	0	0	0	0	1	0	0	0	3488	884	31	1	29	1	CLDN5	22	19511148	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08		19511148	31793418	319	38358										
CYTSA	23384	broad.mit.edu	37	chr22	24717999	24717999	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atttagacagtgagtgcagtGaggtctaccagcccctcaca	10	11	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:24717999G>A	uc002zzw.2	+	5	1358	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	CYTSA_uc002zzv.3_Missense_Mutation_p.E351K|CYTSA_uc011ajq.1_Missense_Mutation_p.E351K	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	351					cell cycle|cell division						0						TGAGTGCAGTGAGGTCTACCA	0.547													0	0	0	0.013537	0	13	66										A	24717999	G	A	24717999	3	1	128	1	0	0	0	0	1	0	0	0	4209	1291	45	1	1061	1	CYTSA	22	24717999	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	5206851	24717999	26586567	320	38359										
NIPSNAP1	8508	broad.mit.edu	37	chr22	29966393	29966393	+	Splice_Site	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gtcagctcagcagccactcaCactggatcttatagaggttg	10	11	4	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:29966393C>A	uc003afx.3	-	2	299	c.226_splice	c.e2+1	p.F76_splice	NIPSNAP1_uc011akp.1_Splice_Site_p.F56_splice	NM_003634	NP_003625	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1									p.?(1)		skin(1)	1						CAGCCACTCACACTGGATCTT	0.567													1	0	0.000157383	0.00308	0.000168295	7	36										A	29966393	C	A	29966393	5	1	128	1	0	0	0	0	0	0	1	0	10429	492	17	4	663	4	NIPSNAP1	22	29966393	Splice_Site	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	5248394	29966393	21338173	321	38360										
PES1	23481	broad.mit.edu	37	chr22	30980647	30980647	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	cgcgggaaggtggaaaacagGaagcacatggagagggcatc	17	7	0	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:30980647G>C	uc003aij.1	-	5	500	c.426C>G	c.(424-426)TTC>TTG	p.F142L	PES1_uc003aik.1_Missense_Mutation_p.F142L|PES1_uc003ail.1_Missense_Mutation_p.F142L|PES1_uc003aim.1_Missense_Mutation_p.F142L|PES1_uc003ain.1_Missense_Mutation_p.F3L|PES1_uc003aio.1_Missense_Mutation_p.F3L	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	142	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						TGGAAAACAGGAAGCACATGG	0.607													0	0	0	0.009096	0	4	27										C	30980647	G	C	30980647	3	2	128	1	0	0	0	0	1	0	0	0	11733	1165	41	1	1384	1	PES1	22	30980647	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1014254	30980647	20323919	322	38361										
PISD	23761	broad.mit.edu	37	chr22	32044244	32044244	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	acatggttcgggcaggggcaGtgtggatttttctggcatct	15	7	2	0			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:32044244G>C	uc003alm.3	-	3	171	c.164C>G	c.(163-165)ACT>AGT	p.T55S	PISD_uc003aln.3_Missense_Mutation_p.T55S	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	55					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	GGCAGGGGCAGTGTGGATTTT	0.527													0	0	0	0.000602	0	5	3										C	32044244	G	C	32044244	3	2	128	1	0	0	0	0	1	0	0	0	11946	1044	36	4		4	PISD	22	32044244	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1063597	32044244	19260322	323	38362										
TOM1	10043	broad.mit.edu	37	chr22	35723369	35723369	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggccgagcccgcagacctgGagctgctgcaggtgagcagg	17	12	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:35723369G>A	uc003ann.2	+	7	879	c.754G>A	c.(754-756)GAG>AAG	p.E252K	TOM1_uc011ami.1_Missense_Mutation_p.E219K|TOM1_uc011amj.1_Missense_Mutation_p.E95K|TOM1_uc003ans.2_Missense_Mutation_p.E95K|TOM1_uc011amk.1_Missense_Mutation_p.E214K|TOM1_uc003anp.2_Missense_Mutation_p.E252K|TOM1_uc011aml.1_Missense_Mutation_p.E207K|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Missense_Mutation_p.E246K|TOM1_uc003anr.2_Missense_Mutation_p.E95K	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	252	GAT.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CGCAGACCTGGAGCTGCTGCA	0.622													0	0	0	0.009096	0	3	22										A	35723369	G	A	35723369	3	1	128	1	0	0	0	0	1	0	0	0	16348	1175	41	1	780	1	TOM1	22	35723369	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3679125	35723369	15581197	324	38363										
TRIOBP	11078	broad.mit.edu	37	chr22	38120564	38120564	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tcctctcctaacagaaccatCcaacaagagaaccccagaac	4	16	1	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chr22:38120564C>G	uc003atr.2	+	7	2272	c.2001C>G	c.(1999-2001)ATC>ATG	p.I667M	TRIOBP_uc003atu.2_Missense_Mutation_p.I495M|TRIOBP_uc003atq.1_Missense_Mutation_p.I667M|TRIOBP_uc003ats.1_Missense_Mutation_p.I495M	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	667					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					ACAGAACCATCCAACAAGAGA	0.572													0	0	0	0.006122	0	18	47										G	38120564	C	G	38120564	3	3	128	1	0	0	0	0	1	0	0	0	16550	845	30	1	2019	1	TRIOBP	22	38120564	Missense_Mutation	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	2397195	38120564	13184002	325	38364										
EDA	1896	broad.mit.edu	37	chrX	69255458	69255458	+	Nonstop_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	gggtgaagcccctgcatcctAgattccccccattttgcctc	8	16	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:69255458A>G	uc004dxs.2	+	8	1417	c.1175A>G	c.(1174-1176)TAG>TGG	p.*392W	EDA_uc004dxr.2_Nonstop_Mutation_p.*390W|EDA_uc011mpj.1_Nonstop_Mutation_p.*387W	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	392					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						CCTGCATCCTAGATTCCCCCC	0.567													0	0	0	0.009535	0	31	34										G	69255458	A	G	69255458	4	3	128	1	0	0	0	0	0	0	0	0	4903	433	15	5	1341	5	EDA	23	69255458	Nonstop_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08		69255458	86015102	326	38365										
ITGB1BP2	26548	broad.mit.edu	37	chrX	70522288	70522288	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctatgggaccacactgtgctGagaagcttcctgaggcccct	11	13	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:70522288G>A	uc004dzr.1	+	4	228	c.199G>A	c.(199-201)GAG>AAG	p.E67K	BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_Missense_Mutation_p.E49K	NM_012278	NP_036410	Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein 2	67					muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)					ACACTGTGCTGAGAAGCTTCC	0.458													0	0	0	0.004482	0	8	16										A	70522288	G	A	70522288	3	1	128	1	0	0	0	0	1	0	0	0	7892	1291	45	1	213	1	ITGB1BP2	23	70522288	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	1266830	70522288	84748272	327	38366										
IL13RA1	3597	broad.mit.edu	37	chrX	117892057	117892057	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	attcatcaatgtgaaaacatCtttagagaaggccaatactt	6	7	3	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:117892057C>T	uc004eqs.2	+	5	571	c.528C>T	c.(526-528)ATC>ATT	p.I176I	IL13RA1_uc004eqr.1_Silent_p.I176I|IL13RA1_uc004eqt.1_Silent_p.I176I	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor	176	Extracellular (Potential).					interleukin-13 receptor complex	cytokine receptor activity				0						GTGAAAACATCTTTAGAGAAG	0.348													0	0	0	0.006122	0	18	46										T	117892057	C	T	117892057	2	4	128	1	0	0	0	0	0	0	0	1	7629	903	32	1		1	IL13RA1	23	117892057	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	47369769	117892057	37378503	328	38367										
IL13RA1	3597	broad.mit.edu	37	chrX	117900535	117900535	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	atccagaatttgagagaaatGtggaggtcagtaaattcaac	10	5	2	3			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:117900535G>A	uc004eqs.2	+	7	914	c.871G>A	c.(871-873)GTG>ATG	p.V291M	IL13RA1_uc004eqt.1_Missense_Mutation_p.V291M	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor	291	Extracellular (Potential).					interleukin-13 receptor complex	cytokine receptor activity				0						TGAGAGAAATGTGGAGGTCAG	0.333													0	0	0	0.00333	0	22	32										A	117900535	G	A	117900535	3	1	128	1	0	0	0	0	1	0	0	0	7629	1377	48	2	897	2	IL13RA1	23	117900535	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	8478	117900535	37370025	329	38368										
DCAF12L2	340578	broad.mit.edu	37	chrX	125298848	125298848	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	ctggtagaagctcagcgaccGcacgcctgtgccaccctctc	10	17	2	1			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:125298848G>C	uc004euk.1	-	1	1087	c.1060C>G	c.(1060-1062)CGG>GGG	p.R354G		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	354	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CTCAGCGACCGCACGCCTGTG	0.637													0	0	0	0.004482	0	9	40										C	125298848	G	C	125298848	3	2	128	1	0	0	0	0	1	0	0	0	4265	1086	38	4	335	4	DCAF12L2	23	125298848	Missense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	7398313	125298848	29971712	330	38369										
SMARCA1	6594	broad.mit.edu	37	chrX	128614761	128614761	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	tgggaaaaattgaaaatcctGaacatttggctgttttggag	11	4	0	2			TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:128614761G>A	uc004eun.3	-	19	2472	c.2359C>T	c.(2359-2361)CAG>TAG	p.Q787*	SMARCA1_uc004eup.3_Nonsense_Mutation_p.Q775*|SMARCA1_uc011muk.1_Nonsense_Mutation_p.Q787*|SMARCA1_uc011mul.1_Nonsense_Mutation_p.Q775*	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	787					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TGAAAATCCTGAACATTTGGC	0.343													0	0	0	0.00245	0	13	12										A	128614761	G	A	128614761	4	1	128	1	0	0	0	0	0	1	0	0	14768	1299	45	1	829	1	SMARCA1	23	128614761	Nonsense_Mutation	SNP	G	TCGA-K4-A3WS-01A-11D-A22Z-08	3315913	128614761	26655799	331	38370										
TKTL1	8277	broad.mit.edu	37	chrX	153539540	153539540	+	Silent	SNP	C	C	T													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	caggcttctcaggtgaagcaCaagcccactgctgtggtggc							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:153539540C>T	uc004fkg.2	+	5	807	c.621C>T	c.(619-621)CAC>CAT	p.H207H	TKTL1_uc011mzl.1_Silent_p.H201H|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Silent_p.H151H	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	207					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGGTGAAGCACAAGCCCACTG	0.587													0	0	0	0.003954	0	25	82										T	153539540	C	T	153539540	2	4	128	1	0	0	0	0	0	0	0	1	15932	477	17	2		2	TKTL1	23	153539540	Silent	SNP	C	TCGA-K4-A3WS-01A-11D-A22Z-08	24924779	153539540	1731020	332	38371	198	2								
TKTL1	8277	broad.mit.edu	37	chrX	153539541	153539541	+	Nonsense_Mutation	SNP	A	A	T													0.319277108433735	106	6.46909441689798e-29	3.17940821582293	3.34437751004016	3.03523337045662	0.896614833460555	0.96330519297415	73	aggcttctcaggtgaagcacAagcccactgctgtggtggcc							TCGA-K4-A3WS-01A-11D-A22Z-08	TCGA-K4-A3WS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98d6bf3c-c9bf-484e-bd1e-b610b255e9a7	0c62c49c-bd98-458e-b702-33bf067420f8	g.chrX:153539541A>T	uc004fkg.2	+	5	808	c.622A>T	c.(622-624)AAG>TAG	p.K208*	TKTL1_uc011mzl.1_Nonsense_Mutation_p.K202*|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Nonsense_Mutation_p.K152*	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	208					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGTGAAGCACAAGCCCACTGC	0.587													0	0	0	0.003954	0	25	83										T	153539541	A	T	153539541	4	4	128	1	0	0	0	0	0	1	0	0	15932	131	5	5	640	5	TKTL1	23	153539541	Nonsense_Mutation	SNP	A	TCGA-K4-A3WS-01A-11D-A22Z-08	1	153539541	1731019	333	38372	198	2								
CDK11B	984	broad.mit.edu	37	chr1	1572053	1572053	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gccagacccaccttgaacacCttgttgatctgatcgatttc	7	13	1	4	rs17424311		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:1572053C>T	uc001agv.1	-	21	2019	c.1908G>A	c.(1906-1908)AAG>AAA	p.K636K	CDK11B_uc009vkj.2_Silent_p.K293K|CDK11B_uc001ags.1_Silent_p.K494K|CDK11B_uc001agt.1_Silent_p.K419K|CDK11B_uc001aha.1_Silent_p.K602K|CDK11B_uc001agw.1_Silent_p.K591K|CDK11B_uc001agy.1_Silent_p.K634K|CDK11B_uc001agx.1_Silent_p.K625K|CDK11B_uc001agz.1_Silent_p.K380K	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	649	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CCTTGAACACCTTGTTGATCT	0.607													0	0	0	0.001984	0	7	64										T	1572053	C	T	1572053	2	4	129	1	0	0	0	0	0	0	0	1	3127	680	24	2		2	CDK11B	1	1572053	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		1572053	247678568	1	38373										
TNFRSF9	3604	broad.mit.edu	37	chr1	7993281	7993281	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	taacaacagagaaacggagcGtgaggaagaacagcaggaag	14	6	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:7993281G>A	uc001aot.2	-	7	748	c.620C>T	c.(619-621)ACG>ATG	p.T207M		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	207	Helical; (Potential).				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GAAACGGAGCGTGAGGAAGAA	0.448													0	0	0	0.000602	0	5	40										A	7993281	G	A	7993281	3	1	129	1	0	0	0	0	1	0	0	0	16297	1145	40	2	155	2	TNFRSF9	1	7993281	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	6421228	7993281	241257340	2	38374										
VPS13D	55187	broad.mit.edu	37	chr1	12378341	12378341	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tggagtagttaccaagcggtCttcccttcctgtgtccaatg	10	11	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:12378341C>T	uc001atv.2	+	31	7502	c.7361C>T	c.(7360-7362)TCT>TTT	p.S2454F	VPS13D_uc001atw.2_Missense_Mutation_p.S2454F|VPS13D_uc001atx.2_Missense_Mutation_p.S1642F|VPS13D_uc001aty.1_Missense_Mutation_p.S192F	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2454					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		ACCAAGCGGTCTTCCCTTCCT	0.443													0	0	0	0.008291	0	11	93										T	12378341	C	T	12378341	3	4	129	1	0	0	0	0	1	0	0	0	17189	913	32	1	7479	1	VPS13D	1	12378341	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4385060	12378341	236872280	3	38375										
DNAJC16	23341	broad.mit.edu	37	chr1	15890478	15890478	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggtggtgtataaaaccctgGaagacccttggattgggagt	15	6	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15890478G>A	uc001aws.2	+	10	1513	c.1393G>A	c.(1393-1395)GAA>AAA	p.E465K	DNAJC16_uc001awr.1_Missense_Mutation_p.E465K|DNAJC16_uc001awt.2_Missense_Mutation_p.E153K|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	465	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TAAAACCCTGGAAGACCCTTG	0.453													0	0	0	0.00278	0	24	206										A	15890478	G	A	15890478	3	1	129	1	0	0	0	0	1	0	0	0	4635	1175	41	1	1427	1	DNAJC16	1	15890478	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3512137	15890478	233360143	4	38376										
DNAJC16	23341	broad.mit.edu	37	chr1	15894468	15894468	+	Missense_Mutation	SNP	G	G	C													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgcctcttcaagccccaaaaGacagtcgaagaggaggaagc							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15894468G>C	uc001aws.2	+	15	2265	c.2145G>C	c.(2143-2145)AAG>AAC	p.K715N	DNAJC16_uc001awt.2_Missense_Mutation_p.K403N|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	715	Extracellular (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGCCCCAAAAGACAGTCGAAG	0.488													0	0	0	0.010729	0	12	100										C	15894468	G	C	15894468	3	2	129	1	0	0	0	0	1	0	0	0	4635	933	33	1	2199	1	DNAJC16	1	15894468	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3990	15894468	233356153	5	38377	199	2								
DNAJC16	23341	broad.mit.edu	37	chr1	15894475	15894475	+	Missense_Mutation	SNP	G	G	A													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcaagccccaaaagacagtcGaagaggaggaagccataggg							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:15894475G>A	uc001aws.2	+	15	2272	c.2152G>A	c.(2152-2154)GAA>AAA	p.E718K	DNAJC16_uc001awt.2_Missense_Mutation_p.E406K|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	718	Poly-Glu.|Extracellular (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAAGACAGTCGAAGAGGAGGA	0.498													0	0	0	0.010729	0	11	96										A	15894475	G	A	15894475	3	1	129	1	0	0	0	0	1	0	0	0	4635	1059	37	1	2206	1	DNAJC16	1	15894475	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	7	15894475	233356146	6	38378	199	2								
PUM1	9698	broad.mit.edu	37	chr1	31439030	31439030	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgctgctggggctggggctGaggctgctgtgttcctaaag	17	9	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:31439030G>A	uc001bsi.1	-	13	1998	c.1885C>T	c.(1885-1887)CAG>TAG	p.Q629*	PUM1_uc001bsf.1_Nonsense_Mutation_p.Q295*|PUM1_uc001bsg.1_Nonsense_Mutation_p.Q442*|PUM1_uc001bsh.1_Nonsense_Mutation_p.Q629*|PUM1_uc001bsj.1_Nonsense_Mutation_p.Q603*|PUM1_uc010oga.1_Nonsense_Mutation_p.Q485*|PUM1_uc001bsk.1_Nonsense_Mutation_p.Q665*|PUM1_uc010ogb.1_Nonsense_Mutation_p.Q570*	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	629					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		ggctggggctgaggctgCTGT	0.423													0	0	0	0.00632	0	29	98										A	31439030	G	A	31439030	4	1	129	1	0	0	0	0	0	1	0	0	12825	1299	45	1	1721	1	PUM1	1	31439030	Nonsense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	15544555	31439030	217811591	7	38379										
MAP7D1	55700	broad.mit.edu	37	chr1	36640550	36640550	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cctgcccaaacacgtggactCtataatcaacaagcggctct	7	14	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:36640550C>T	uc001bzz.2	+	6	1007	c.791C>T	c.(790-792)TCT>TTT	p.S264F	MAP7D1_uc001caa.2_Missense_Mutation_p.S264F|MAP7D1_uc001cab.2_Intron|MAP7D1_uc001cac.2_5'UTR|MAP7D1_uc001cad.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	264						cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CACGTGGACTCTATAATCAAC	0.607													0	0	0	0.009096	0	4	36										T	36640550	C	T	36640550	3	4	129	1	0	0	0	0	1	0	0	0	9267	913	32	1	813	1	MAP7D1	1	36640550	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	5201520	36640550	212610071	8	38380										
THRAP3	9967	broad.mit.edu	37	chr1	36766675	36766675	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aagaggaggtggcagagctcGaggaacctttgtaagacctt	14	7	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:36766675G>A	uc001cae.3	+	10	2716	c.2492G>A	c.(2491-2493)CGA>CAA	p.R831Q	THRAP3_uc001caf.3_Missense_Mutation_p.R831Q	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	831					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GGCAGAGCTCGAGGAACCTTT	0.502			T	USP6	aneurysmal bone cysts								0	0	0	0.009096	0	4	41										A	36766675	G	A	36766675	3	1	129	1	0	0	0	0	1	0	0	0	15871	1058	37	1	2522	1	THRAP3	1	36766675	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	126125	36766675	212483946	9	38381										
PPCS	79717	broad.mit.edu	37	chr1	42922346	42922346	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggcgcgcagggccggcgggTggtgttggttacgtcaggcg	22	9	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:42922346T>G	uc001chl.2	+	1	174	c.110T>G	c.(109-111)GTG>GGG	p.V37G	ZMYND12_uc001chj.2_5'Flank|ZMYND12_uc010ojt.1_5'Flank|PPCS_uc001chk.2_Intron	NM_024664	NP_078940	Q9HAB8	PPCS_HUMAN	phosphopantothenoylcysteine synthetase isoform	37					coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGCCGGCGGGTGGTGTTGGTT	0.711													0	0	0	0.011902	0	10	35										G	42922346	T	G	42922346	3	3	129	1	0	0	0	0	1	0	0	0	12305	1696	59	5	112	5	PPCS	1	42922346	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	6155671	42922346	206328275	10	38382										
KIAA0467	23334	broad.mit.edu	37	chr1	43868912	43868912	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcgaatctcccgaaatgttcGcctggcttggttcctcagtc	9	13	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:43868912G>A	uc009vws.1	+	2	176	c.92G>A	c.(91-93)CGC>CAC	p.R31H	C1orf84_uc001cjh.2_Missense_Mutation_p.R31H|C1orf84_uc001cji.1_RNA			Q5T011	SZT2_HUMAN	Homo sapiens mRNA for KIAA0467 protein, partial cds.	31						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CGAAATGTTCGCCTGGCTTGG	0.493													0	0	0	0.001168	0	6	63										A	43868912	G	A	43868912	3	1	129	1	0	0	0	0	1	0	0	0	8178	1087	38	2		2	KIAA0467	1	43868912	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	946566	43868912	205381709	11	38383										
KIAA0467	23334	broad.mit.edu	37	chr1	43898837	43898837	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgtccgggtcctgcaggaccGtgtggaagtgtatgcacatg	15	9	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:43898837G>A	uc001cjk.1	+	25	3545	c.3083G>A	c.(3082-3084)CGT>CAT	p.R1028H		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1927						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGCAGGACCGTGTGGAAGTG	0.607													0	0	0	0.001855	0	13	122										A	43898837	G	A	43898837	3	1	129	1	0	0	0	0	1	0	0	0	8178	1145	40	2	3173	2	KIAA0467	1	43898837	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	29925	43898837	205351784	12	38384										
TSPAN1	10103	broad.mit.edu	37	chr1	46650908	46650908	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttcctgaagggttgcttcaaTcagcttttgtatgacatccg	9	9	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:46650908T>C	uc001cpd.2	+	8	1070	c.606T>C	c.(604-606)AAT>AAC	p.N202N	TSPAN1_uc009vyd.1_Silent_p.N202N	NM_005727	NP_005718	O60635	TSN1_HUMAN	tetraspan 1	202	Extracellular (Potential).					integral to membrane|lysosomal membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GTTGCTTCAATCAGCTTTTGT	0.537													0	0	0	0.008871	0	19	300										C	46650908	T	C	46650908	2	2	129	1	0	0	0	0	0	0	0	1	16630	1432	50	5		5	TSPAN1	1	46650908	Silent	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	2752071	46650908	202599713	13	38385										
CYP4A11	1579	broad.mit.edu	37	chr1	47395912	47395912	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggtgggatcaggcagcagctCaaagcggagcagggtcaggg	19	8	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:47395912C>G	uc001cqp.3	-	12	1486	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	479					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GGCAGCAGCTCAAAGCGGAGC	0.547													0	0	0	0.010729	0	11	151										G	47395912	C	G	47395912	3	3	129	1	0	0	0	0	1	0	0	0	4183	835	29	1	128	1	CYP4A11	1	47395912	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	745004	47395912	201854709	14	38386										
C8A	731	broad.mit.edu	37	chr1	57347200	57347200	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agtgtgagacggtatacaatGgggaatggagggagcttcga	17	4	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:57347200G>C	uc001cyo.2	+	5	679	c.547G>C	c.(547-549)GGG>CGG	p.G183R		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	183	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GGTATACAATGGGGAATGGAG	0.463													0	0	0	0.008291	0	8	133										C	57347200	G	C	57347200	3	2	129	1	0	0	0	0	1	0	0	0	2416	1348	47	4	565	4	C8A	1	57347200	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	9951288	57347200	191903421	15	38387										
ZZZ3	26009	broad.mit.edu	37	chr1	78098534	78098536	+	In_Frame_Del	DEL	AGT	AGT	-													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cccttttctcacaatcatccAgtataagacatcgacaagct							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:78098534_78098536delAGT	uc001dhq.2	-	5	980_982	c.504_506delACT	c.(502-507)ATACTG>ATG	p.168_169IL>M	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_In_Frame_Del_p.168_169IL>M|ZZZ3_uc001dhp.2_In_Frame_Del_p.168_169IL>M	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	168_169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						ACAATCATCCAGTATAAGACATC	0.409																		14	223	---	---								-	78098536	AGT	-	78098534	7	5	129	1	0	1	0	1	0	0	0	0	18253	188	7	0	2249	0	ZZZ3	1	78098534	In_Frame_Del	DEL	AGT	TCGA-K4-A3WU-01B-11D-A23M-08	20751334	78098534	171152087	16	38388										
TXNIP	10628	broad.mit.edu	37	chr1	145440476	145440476	+	Missense_Mutation	SNP	G	G	C													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccttcgggttcagaagatcaGgccttctatcctgggctgca							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440476G>C	uc001enn.3	+	5	1123	c.782G>C	c.(781-783)AGG>ACG	p.R261T	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.R206T	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	261					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CAGAAGATCAGGCCTTCTATC	0.488													0	0	0	0.005443	0	25	186										C	145440476	G	C	145440476	3	2	129	1	0	0	0	0	1	0	0	0	16800	1000	35	4	800	4	TXNIP	1	145440476	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	67341942	145440476	103810145	17	38389	200	2								
TXNIP	10628	broad.mit.edu	37	chr1	145440481	145440481	+	Missense_Mutation	SNP	T	T	C													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggttcagaagatcaggcctTctatcctgggctgcaacatc							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440481T>C	uc001enn.3	+	5	1128	c.787T>C	c.(787-789)TCT>CCT	p.S263P	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.S208P	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	263					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GATCAGGCCTTCTATCCTGGG	0.493													0	0	0	0.00632	0	25	185										C	145440481	T	C	145440481	3	2	129	1	0	0	0	0	1	0	0	0	16800	1783	62	5	805	5	TXNIP	1	145440481	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	5	145440481	103810140	18	38390	200	2								
TXNIP	10628	broad.mit.edu	37	chr1	145440508	145440509	+	Frame_Shift_Ins	INS	-	-	T													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggctgcaacatccttcgagINSttgaatattccttactggtg							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:145440508_145440509insT	uc001enn.3	+	5	1155_1156	c.814_815insT	c.(814-816)GTTfs	p.V272fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Ins_p.V217fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	272					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATCCTTCGAGTTGAATATTCC	0.485																		20	184	---	---								T	145440509	-	T	145440508	7	5	129	1	0	1	1	0	0	0	0	0	16800	1029	36	0	832	0	TXNIP	1	145440508	Frame_Shift_Ins	INS	-	TCGA-K4-A3WU-01B-11D-A23M-08	27	145440508	103810113	19	38391										
TCHH	7062	broad.mit.edu	37	chr1	152080154	152080154	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cgtggcaaactgctcctccgCccggtactgccggtctcgct	11	17	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152080154C>T	uc001ezp.2	-	2	5539	c.5539G>A	c.(5539-5541)GCG>ACG	p.A1847T	TCHH_uc009wne.1_Missense_Mutation_p.A1847T	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1847	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCCTCCGCCCGGTACTGC	0.572													0	0	0	0.006214	0	8	103										T	152080154	C	T	152080154	3	4	129	1	0	0	0	0	1	0	0	0	15697	739	26	2	296	2	TCHH	1	152080154	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	6639646	152080154	97170467	20	38392										
TCHH	7062	broad.mit.edu	37	chr1	152080660	152080660	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcagctgctgttcctcccctTcctggagcagctgttcctct	9	16	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152080660T>G	uc001ezp.2	-	2	5033	c.5033A>C	c.(5032-5034)GAA>GCA	p.E1678A	TCHH_uc009wne.1_Missense_Mutation_p.E1678A	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1678	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCCCCTTCCTGGAGCAG	0.597													0	0	0	0.006122	0	17	170										G	152080660	T	G	152080660	3	3	129	1	0	0	0	0	1	0	0	0	15697	1783	62	5	802	5	TCHH	1	152080660	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	506	152080660	97169961	21	38393										
TCHH	7062	broad.mit.edu	37	chr1	152084447	152084447	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctcgcgcctcagctgctgctCgcgcctcagctgctgctcgc	11	19	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152084447C>T	uc001ezp.2	-	2	1246	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	TCHH_uc009wne.1_Missense_Mutation_p.E416K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	416	8 X 6 AA tandem repeats of R-R-E-Q-Q-L.|2-7.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			Agctgctgctcgcgcctcagc	0.095													0	0	0	0.000602	0	5	30										T	152084447	C	T	152084447	3	4	129	1	0	0	0	0	1	0	0	0	15697	893	31	1	4589	1	TCHH	1	152084447	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	3787	152084447	97166174	22	38394										
FLG2	388698	broad.mit.edu	37	chr1	152325730	152325730	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aatgtgtgtgcgagccccctGagtgcacttcactgtcactg	11	12	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:152325730G>C	uc001ezw.3	-	3	4605	c.4532C>G	c.(4531-4533)TCA>TGA	p.S1511*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1511							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGAGCCCCCTGAGTGCACTTC	0.493													0	0	0	0.01441	0	88	364										C	152325730	G	C	152325730	4	2	129	1	0	0	0	0	0	1	0	0	5923	1294	45	1	2647	1	FLG2	1	152325730	Nonsense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	241283	152325730	96924891	23	38395										
OR10J1	26476	broad.mit.edu	37	chr1	159409753	159409753	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tggatcttcatcttcacacaCccatgtacttcttcctgagc	5	14	5	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:159409753C>A	uc010piv.1	+	1	205	c.205C>A	c.(205-207)CCC>ACC	p.P69T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	69	Helical; Name=2; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TCTTCACACACCCATGTACTT	0.458													1	0	1.12685e-05	0.004482	1.18264e-05	9	160										A	159409753	C	A	159409753	3	1	129	1	0	0	0	0	1	0	0	0	10910	507	18	4	207	4	OR10J1	1	159409753	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	7084023	159409753	89840868	24	38396										
FCGR2B	2213	broad.mit.edu	37	chr1	161641372	161641372	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aaggccaacaacaatgacagCggggagtacacgtgccagac	12	11	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:161641372C>T	uc001gaz.1	+	3	416	c.324C>T	c.(322-324)AGC>AGT	p.S108S	FCGR2B_uc009wum.1_Silent_p.S108S|FCGR2B_uc001gay.1_Silent_p.S107S|FCGR2B_uc001gba.1_Silent_p.S107S|FCGR2B_uc001gbb.1_Silent_p.S108S|FCGR2B_uc009wun.1_Silent_p.S101S	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	108	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACAATGACAGCGGGGAGTACA	0.592			T	NaN	ALL								0	0	0	0.010729	0	10	155										T	161641372	C	T	161641372	2	4	129	1	0	0	0	0	0	0	0	1	5782	767	27	2		2	FCGR2B	1	161641372	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2231619	161641372	87609249	25	38397										
TOR1AIP1	26092	broad.mit.edu	37	chr1	179852011	179852011	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aaccgaggaaatgaagacgcGaaggactacccgccttcagc	11	12	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:179852011G>A	uc001gnq.2	+	1	592	c.374G>A	c.(373-375)CGA>CAA	p.R125Q	TOR1AIP1_uc001gnp.1_Missense_Mutation_p.R125Q	NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	125	Nuclear (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						ATGAAGACGCGAAGGACTACC	0.587													0	0	0	0.006214	0	9	90										A	179852011	G	A	179852011	3	1	129	1	0	0	0	0	1	0	0	0	16369	1058	37	1	376	1	TOR1AIP1	1	179852011	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	18210639	179852011	69398610	26	38398										
KIF21B	23046	broad.mit.edu	37	chr1	200946381	200946381	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acggcattgcccgaggcggcGtacagcatggtgcccgaagg	16	12	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:200946381G>A	uc001gvs.1	-	31	4601	c.4284C>T	c.(4282-4284)TAC>TAT	p.Y1428Y	KIF21B_uc001gvr.1_Silent_p.Y1415Y|KIF21B_uc009wzl.1_Silent_p.Y1428Y|KIF21B_uc010ppn.1_Silent_p.Y1415Y	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	1428	WD 3.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						CCGAGGCGGCGTACAGCATGG	0.642													0	0	0	0.009096	0	4	150										A	200946381	G	A	200946381	2	1	129	1	0	0	0	0	0	0	0	1	8289	1140	40	2		2	KIF21B	1	200946381	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	21094370	200946381	48304240	27	38399										
ATP2B4	493	broad.mit.edu	37	chr1	203681223	203681223	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggatgacttcctgtgcttaGaaggcaaagaattcaaccgg	12	8	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:203681223G>C	uc001gzw.2	+	13	3051	c.2167G>C	c.(2167-2169)GAA>CAA	p.E723Q	ATP2B4_uc001gzv.2_Missense_Mutation_p.E723Q|ATP2B4_uc009xaq.2_Missense_Mutation_p.E723Q	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	723	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCTGTGCTTAGAAGGCAAAGA	0.542													0	0	0	0.006214	0	9	81										C	203681223	G	C	203681223	3	2	129	1	0	0	0	0	1	0	0	0	1142	943	33	1	2213	1	ATP2B4	1	203681223	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2734842	203681223	45569398	28	38400										
RPS6KC1	26750	broad.mit.edu	37	chr1	213415603	213415603	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agagagggaattgtgtgccgCgatttgaacccaaacaacat	11	8	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:213415603C>T	uc010ptr.1	+	11	2943	c.2784C>T	c.(2782-2784)CGC>CGT	p.R928R	RPS6KC1_uc001hkd.2_Silent_p.R916R|RPS6KC1_uc010pts.1_Silent_p.R716R|RPS6KC1_uc010ptt.1_Silent_p.R716R|RPS6KC1_uc010ptu.1_Silent_p.R747R|RPS6KC1_uc010ptv.1_Silent_p.R463R|RPS6KC1_uc001hke.2_Silent_p.R747R	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	928	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TTGTGTGCCGCGATTTGAACC	0.433													0	0	0	0.006214	0	9	102										T	213415603	C	T	213415603	2	4	129	1	0	0	0	0	0	0	0	1	13658	755	27	2		2	RPS6KC1	1	213415603	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	9734380	213415603	35835018	29	38401										
LYST	1130	broad.mit.edu	37	chr1	235826288	235826288	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaatagaacattggctgtttCaagcgctgctggtccttccg	11	10	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:235826288C>T	uc001hxj.2	-	53	11533	c.11358G>A	c.(11356-11358)TTG>TTA	p.L3786L	LYST_uc001hxi.2_Silent_p.L1010L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3786	WD 7.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTGGCTGTTTCAAGCGCTGCT	0.458									Chediak-Higashi_syndrome				0	0	0	0.004482	0	9	118										T	235826288	C	T	235826288	2	4	129	1	0	0	0	0	0	0	0	1	9128	825	29	1		1	LYST	1	235826288	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	22410685	235826288	13424333	30	38402										
LYST	1130	broad.mit.edu	37	chr1	235972124	235972124	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aagaaggactggataaacttGaggagagttcagcatcacat	11	6	2	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:235972124G>A	uc001hxj.2	-	5	2169	c.1994C>T	c.(1993-1995)TCA>TTA	p.S665L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.S665L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	665	WD 1.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGATAAACTTGAGGAGAGTTC	0.408									Chediak-Higashi_syndrome				0	0	0	0.000602	0	5	70										A	235972124	G	A	235972124	3	1	129	1	0	0	0	0	1	0	0	0	9128	1294	45	1	9607	1	LYST	1	235972124	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	145836	235972124	13278497	31	38403										
OR2T12	127064	broad.mit.edu	37	chr1	248458397	248458397	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	accgcaatatgggaagctcaGggtagcaacagcctgcagga	13	10	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr1:248458397G>T	uc010pzj.1	-	1	484	c.484C>A	c.(484-486)CTG>ATG	p.L162M		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGGAAGCTCAGGGTAGCAACA	0.577													1	0	0.00307968	0.00308	0.00312888	8	193										T	248458397	G	T	248458397	3	4	129	1	0	0	0	0	1	0	0	0	11019	991	35	4	481	4	OR2T12	1	248458397	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	12486273	248458397	792224	32	38404										
TRIB2	28951	broad.mit.edu	37	chr2	12863643	12863643	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggctggtgctgcgggacctCaagctgcggaaattcatctt	14	10	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:12863643C>T	uc002rbv.3	+	2	1964	c.528C>T	c.(526-528)CTC>CTT	p.L176L	TRIB2_uc010yjp.1_Silent_p.L40L	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	176	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGCGGGACCTCAAGCTGCGGA	0.562													0	0	0	0.013537	0	12	89										T	12863643	C	T	12863643	2	4	129	1	0	0	0	0	0	0	0	1	16480	813	29	1		1	TRIB2	2	12863643	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		12863643	230335730	33	38405										
APOB	338	broad.mit.edu	37	chr2	21229266	21229266	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcctttggtagatgactcaaTggaaaagtaagaggtgaggc	13	5	1	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:21229266T>A	uc002red.2	-	26	10602	c.10474A>T	c.(10474-10476)ATT>TTT	p.I3492F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3492	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGACTCAATGGAAAAGTAA	0.418													0	0	0	0.006122	0	19	83										A	21229266	T	A	21229266	3	1	129	1	0	0	0	0	1	0	0	0	785	1464	51	5	3233	5	APOB	2	21229266	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	8365623	21229266	221970107	34	38406										
KRTCAP3	200634	broad.mit.edu	37	chr2	27665507	27665507	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcgctgatcttggtgggccaCgtgaacctgctgctgggggc	17	11	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:27665507C>T	uc002rks.2	+	2	107	c.90C>T	c.(88-90)CAC>CAT	p.H30H	KRTCAP3_uc010ylr.1_Silent_p.H30H|KRTCAP3_uc002rkt.2_Silent_p.H12H	NM_173853	NP_776252	Q53RY4	KCP3_HUMAN	keratinocyte associated protein 3	30	Helical; (Potential).					integral to membrane					0	Acute lymphoblastic leukemia(172;0.155)					TGGTGGGCCACGTGAACCTGC	0.597													0	0	0	0.001168	0	6	27										T	27665507	C	T	27665507	2	4	129	1	0	0	0	0	0	0	0	1	8579	535	19	2		2	KRTCAP3	2	27665507	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	6436241	27665507	215533866	35	38407										
FAM179A	165186	broad.mit.edu	37	chr2	29268244	29268244	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agtgcgtttcctgagtggccGtgcggtgctggatgtcacag	16	9	1	1	rs150801790		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:29268244G>A	uc010ezl.2	+	19	3041	c.2690G>A	c.(2689-2691)CGT>CAT	p.R897H	FAM179A_uc010ymm.1_Missense_Mutation_p.R842H|FAM179A_uc002rmr.3_Missense_Mutation_p.R424H|FAM179A_uc002rms.1_Missense_Mutation_p.R195H	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	897							binding			ovary(3)|skin(1)	4						CTGAGTGGCCGTGCGGTGCTG	0.612													0	0	0	0.010504	0	19	102										A	29268244	G	A	29268244	3	1	129	1	0	0	0	0	1	0	0	0	5505	1145	40	2	2760	2	FAM179A	2	29268244	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1602737	29268244	213931129	36	38408										
NLRC4	58484	broad.mit.edu	37	chr2	32476278	32476278	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gccaggtatatccaggagttGatcacagagggtttcaaaaa	11	7	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:32476278G>C	uc002roi.2	-	4	901	c.655C>G	c.(655-657)CAA>GAA	p.Q219E	NLRC4_uc002roj.1_Missense_Mutation_p.Q219E|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	219	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCCAGGAGTTGATCACAGAGG	0.517													0	0	0	0.00245	0	15	71										C	32476278	G	C	32476278	3	2	129	1	0	0	0	0	1	0	0	0	10469	1299	45	1	2443	1	NLRC4	2	32476278	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3208034	32476278	210723095	37	38409										
GPR75	10936	broad.mit.edu	37	chr2	54080472	54080472	+	Frame_Shift_Del	DEL	G	G	-													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggttcaatccgagtgttgatGggggtcgagctgctctgacc							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:54080472delG	uc002rxo.3	-	2	1693	c.1422delC	c.(1420-1422)CCCfs	p.P474fs	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	474	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GAGTGTTGATGGGGGTCGAGC	0.493																		19	312	---	---								-	54080472	G	-	54080472	7	5	129	1	0	1	0	1	0	0	0	0	6708	1335	47	0	204	0	GPR75	2	54080472	Frame_Shift_Del	DEL	G	TCGA-K4-A3WU-01B-11D-A23M-08	21604194	54080472	189118901	38	38410										
CCDC88A	55704	broad.mit.edu	37	chr2	55566659	55566659	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gattttggaagcattgccttCtacagaatccacagtagtcc	8	10	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:55566659C>G	uc002ryv.2	-	13	2301	c.1459G>C	c.(1459-1461)GAA>CAA	p.E487Q	CCDC88A_uc010yoz.1_Missense_Mutation_p.E487Q|CCDC88A_uc010ypa.1_Missense_Mutation_p.E487Q|CCDC88A_uc010ypb.1_Missense_Mutation_p.E389Q	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	487	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GCATTGCCTTCTACAGAATCC	0.323													0	0	0	0.000602	0	5	61										G	55566659	C	G	55566659	3	3	129	1	0	0	0	0	1	0	0	0	2863	922	32	1	4236	1	CCDC88A	2	55566659	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1486187	55566659	187632714	39	38411										
HK2	3099	broad.mit.edu	37	chr2	75116424	75116424	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcctgcaacacttagggcttGagagcacctgtgacgacagc	11	12	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:75116424G>C	uc002snd.2	+	17	4354	c.2428G>C	c.(2428-2430)GAG>CAG	p.E810Q		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	810	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CTTAGGGCTTGAGAGCACCTG	0.617													0	0	0	0.004482	0	8	44										C	75116424	G	C	75116424	3	2	129	1	0	0	0	0	1	0	0	0	7191	1291	45	1	2494	1	HK2	2	75116424	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	19549765	75116424	168082949	40	38412										
REG1A	5967	broad.mit.edu	37	chr2	79348757	79348757	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aggcaccaatgcctatcgctCctactgctactactttaatg	6	13	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:79348757C>T	uc002snz.2	+	3	237	c.134C>T	c.(133-135)TCC>TTC	p.S45F	REG1A_uc010ffx.1_Missense_Mutation_p.S45F|REG1A_uc010ysd.1_Missense_Mutation_p.S45F	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	45	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GCCTATCGCTCCTACTGCTAC	0.542													0	0	0	0.006214	0	10	480										T	79348757	C	T	79348757	3	4	129	1	0	0	0	0	1	0	0	0	13210	855	30	1	140	1	REG1A	2	79348757	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4232333	79348757	163850616	41	38413										
VWA3B	200403	broad.mit.edu	37	chr2	98804557	98804557	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aagtgcaagtggtacagtgaGagaatccacacagccctggc	12	10	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:98804557G>C	uc002syo.2	+	10	1695	c.1431G>C	c.(1429-1431)GAG>GAC	p.E477D	VWA3B_uc010yvh.1_Missense_Mutation_p.E327D|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_Intron|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Missense_Mutation_p.E477D|VWA3B_uc002syn.1_Intron|VWA3B_uc010yvi.1_Missense_Mutation_p.E134D	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	477										ovary(3)|large_intestine(2)|skin(1)	6						GGTACAGTGAGAGAATCCACA	0.502													0	0	0	0.010504	0	20	95										C	98804557	G	C	98804557	3	2	129	1	0	0	0	0	1	0	0	0	17238	933	33	1	1465	1	VWA3B	2	98804557	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	19455800	98804557	144394816	42	38414										
LONRF2	164832	broad.mit.edu	37	chr2	100903525	100903525	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttcatactctggaccctccaCctgatcagggaaagaggcac	9	13	3	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:100903525C>T	uc002tal.3	-	11	2561	c.1921G>A	c.(1921-1923)GTG>ATG	p.V641M	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	641	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						GGACCCTCCACCTGATCAGGG	0.507													0	0	0	0.001168	0	5	41										T	100903525	C	T	100903525	3	4	129	1	0	0	0	0	1	0	0	0	8895	521	18	2	351	2	LONRF2	2	100903525	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2098968	100903525	142295848	43	38415										
BUB1	699	broad.mit.edu	37	chr2	111408235	111408235	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcagtgtctgtgagtctgcaAgcctcaacgcccaactctgc	9	14	5	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:111408235A>G	uc002tgc.2	-	18	2203	c.2091T>C	c.(2089-2091)GCT>GCC	p.A697A	BUB1_uc010yxh.1_Silent_p.A677A|BUB1_uc010fkb.2_Silent_p.A697A	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	697					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TGAGTCTGCAAGCCTCAACGC	0.537													0	0	0	0.009096	0	4	39										G	111408235	A	G	111408235	2	3	129	1	0	0	0	0	0	0	0	1	1570	59	3	5		5	BUB1	2	111408235	Silent	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	10504710	111408235	131791138	44	38416										
BUB1	699	broad.mit.edu	37	chr2	111408294	111408294	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acctgcagcaggctggctcaGacgaagtaaggatgctgaat	13	9	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:111408294G>C	uc002tgc.2	-	18	2144	c.2032C>G	c.(2032-2034)CTG>GTG	p.L678V	BUB1_uc010yxh.1_Missense_Mutation_p.L658V|BUB1_uc010fkb.2_Missense_Mutation_p.L678V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	678					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GGCTGGCTCAGACGAAGTAAG	0.502													0	0	0	0.004672	0	3	48										C	111408294	G	C	111408294	3	2	129	1	0	0	0	0	1	0	0	0	1570	933	33	1	1257	1	BUB1	2	111408294	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	59	111408294	131791079	45	38417										
CNTNAP5	129684	broad.mit.edu	37	chr2	125671724	125671724	+	Silent	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atcatcggcatcatgacccgGttcctctaccagcacaagca	7	15	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:125671724G>C	uc002tno.2	+	24	4144	c.3780G>C	c.(3778-3780)CGG>CGC	p.R1260R	CNTNAP5_uc010flu.2_Silent_p.R1261R	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1260	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCATGACCCGGTTCCTCTACC	0.453													0	0	0	0.004482	0	8	160										C	125671724	G	C	125671724	2	2	129	1	0	0	0	0	0	0	0	1	3650	1248	44	4		4	CNTNAP5	2	125671724	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	14263430	125671724	117527649	46	38418										
SAP130	79595	broad.mit.edu	37	chr2	128767935	128767935	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gttgctaccacagcaggaggGatggcattggaggtggtcac	16	8	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:128767935G>C	uc002tpp.2	-	7	987	c.855C>G	c.(853-855)ATC>ATG	p.I285M	SAP130_uc002tpn.2_Missense_Mutation_p.I46M|SAP130_uc002tpo.2_Missense_Mutation_p.I30M|SAP130_uc010fmd.2_Missense_Mutation_p.I285M|SAP130_uc002tpq.1_Missense_Mutation_p.I259M	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	285					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CAGCAGGAGGGATGGCATTGG	0.448													0	0	0	0.009096	0	4	94										C	128767935	G	C	128767935	3	2	129	1	0	0	0	0	1	0	0	0	13831	1164	41	1	2456	1	SAP130	2	128767935	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3096211	128767935	114431438	47	38419										
XIRP2	129446	broad.mit.edu	37	chr2	168101899	168101899	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	accgagaagggtcctatcatGaagtgaccacagttaaaaaa	9	8	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:168101899G>C	uc002udx.2	+	8	4015	c.3997G>C	c.(3997-3999)GAA>CAA	p.E1333Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E1158Q|XIRP2_uc010fpq.2_Missense_Mutation_p.E1111Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1158					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GTCCTATCATGAAGTGACCAC	0.383													0	0	0	0.006214	0	10	60										C	168101899	G	C	168101899	3	2	129	1	0	0	0	0	1	0	0	0	17427	1291	45	1	4027	1	XIRP2	2	168101899	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	39333964	168101899	75097474	48	38420										
LRP2	4036	broad.mit.edu	37	chr2	170055326	170055326	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agggttttcatcactgttatCtccacagtcattgtctccgt	7	11	5	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:170055326C>G	uc002ues.2	-	45	8761	c.8548G>C	c.(8548-8550)GAT>CAT	p.D2850H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2850	LDL-receptor class A 19.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCACTGTTATCTCCACAGTCA	0.378													0	0	0	0.009096	0	3	38										G	170055326	C	G	170055326	3	3	129	1	0	0	0	0	1	0	0	0	8956	913	32	1	5559	1	LRP2	2	170055326	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1953427	170055326	73144047	49	38421										
SGOL2	151246	broad.mit.edu	37	chr2	201436243	201436243	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aaagtaataaaaaaacaaatGaacatggaatgaaaactttc	5	4	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:201436243G>A	uc002uvw.2	+	7	1287	c.1174G>A	c.(1174-1176)GAA>AAA	p.E392K	SGOL2_uc010zhd.1_Missense_Mutation_p.E392K|SGOL2_uc010zhe.1_Missense_Mutation_p.E392K	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	392					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						AAAAACAAATGAACATGGAAT	0.318													0	0	0	0.001168	0	6	56										A	201436243	G	A	201436243	3	1	129	1	0	0	0	0	1	0	0	0	14217	1291	45	1	1196	1	SGOL2	2	201436243	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	31380917	201436243	41763130	50	38422										
CUL3	8452	broad.mit.edu	37	chr2	225371615	225371615	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctttccttctccttcttcaGaaacaagagctttaccttgc	4	13	4	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:225371615G>T	uc002vny.2	-	7	1373	c.989C>A	c.(988-990)TCT>TAT	p.S330Y	CUL3_uc010zls.1_Missense_Mutation_p.S264Y|CUL3_uc010fwy.1_Missense_Mutation_p.S336Y	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	330					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCCTTCTTCAGAAACAAGAGC	0.378													1	0	0.00307968	0.00308	0.00312888	8	45										T	225371615	G	T	225371615	3	4	129	1	0	0	0	0	1	0	0	0	4056	942	33	3	1357	3	CUL3	2	225371615	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	23935372	225371615	17827758	51	38423										
HDLBP	3069	broad.mit.edu	37	chr2	242169088	242169088	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgggaaattcctcagagctGctcatgtcaggagcctgtgc	12	11	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr2:242169088G>A	uc002waz.2	-	28	3963	c.3735C>T	c.(3733-3735)AGC>AGT	p.S1245S	HDLBP_uc002wba.2_Silent_p.S1245S|HDLBP_uc002wbb.2_Silent_p.S1197S	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	1245					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		CCTCAGAGCTGCTCATGTCAG	0.582													0	0	0	0.001984	0	6	43										A	242169088	G	A	242169088	2	1	129	1	0	0	0	0	0	0	0	1	7025	1310	46	2		2	HDLBP	2	242169088	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	16797473	242169088	1030285	52	38424										
FANCD2	2177	broad.mit.edu	37	chr3	10089628	10089628	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aggatatgtgttcatccattCtgtcgctggctcagagtttg	11	8	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:10089628C>A	uc003buw.2	+	16	1384	c.1306C>A	c.(1306-1308)CTG>ATG	p.L436M	FANCD2_uc003bux.1_Missense_Mutation_p.L436M|FANCD2_uc003buy.1_Missense_Mutation_p.L436M|FANCD2_uc010hcw.1_5'Flank	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	436					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TTCATCCATTCTGTCGCTGGC	0.393			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	5.45024e-15	0.00333	5.99715e-15	26	255										A	10089628	C	A	10089628	3	1	129	1	0	0	0	0	1	0	0	0	5665	912	32	3	1364	3	FANCD2	3	10089628	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		10089628	187932802	53	38425										
ATP2B2	491	broad.mit.edu	37	chr3	10442706	10442706	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctctccagttagggagctttCatcaatcttgaggtcattgc	9	10	5	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:10442706C>T	uc003bvt.2	-	5	1151	c.712G>A	c.(712-714)GAA>AAA	p.E238K	ATP2B2_uc003bvv.2_Missense_Mutation_p.E238K|ATP2B2_uc003bvw.2_Missense_Mutation_p.E238K|ATP2B2_uc010hdp.2_Missense_Mutation_p.E238K|ATP2B2_uc010hdo.2_5'UTR	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	238	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						AGGGAGCTTTCATCAATCTTG	0.592													0	0	0	0.004007	0	17	84										T	10442706	C	T	10442706	3	4	129	1	0	0	0	0	1	0	0	0	1140	835	29	1	3095	1	ATP2B2	3	10442706	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	353078	10442706	187579724	54	38426										
PPARG	5468	broad.mit.edu	37	chr3	12447544	12447544	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccgctgaccaaagcaaaggcGagggcgatcttgacaggaaa	13	10	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:12447544G>C	uc003bwx.2	+	5	874	c.783G>C	c.(781-783)GCG>GCC	p.A261A	PPARG_uc003bwr.2_Silent_p.A233A|PPARG_uc003bws.2_Silent_p.A233A|PPARG_uc003bwu.2_Silent_p.A233A|PPARG_uc003bwv.2_Silent_p.A233A|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Silent_p.A233A|PPARG_uc003bwt.1_Silent_p.A233A|PPARG_uc003bww.1_Silent_p.A261A	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	261	Interaction with FAM120B (By similarity).				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	AAGCAAAGGCGAGGGCGATCT	0.478			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						0	0	0	0.004482	0	9	53										C	12447544	G	C	12447544	2	2	129	1	0	0	0	0	0	0	0	1	12299	1045	37	1		1	PPARG	3	12447544	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2004838	12447544	185574886	55	38427										
CAND2	23066	broad.mit.edu	37	chr3	12861592	12861592	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcttgtcctgcaggtcggccAcacacccggagcaccgtcat	10	16	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:12861592A>G	uc003bxk.2	+	11	3001	c.2952A>G	c.(2950-2952)CCA>CCG	p.P984P	CAND2_uc003bxj.2_Silent_p.P891P	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	984	HEAT 21.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CAGGTCGGCCACACACCCGGA	0.597													0	0	0	0.001855	0	14	106										G	12861592	A	G	12861592	2	3	129	1	0	0	0	0	0	0	0	1	2616	146	6	5		5	CAND2	3	12861592	Silent	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	414048	12861592	185160838	56	38428										
C3orf35	339883	broad.mit.edu	37	chr3	37476522	37476522	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cacctggtgcgtggggatgcCtggaaaacaaaattaggaga	14	7	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:37476522C>T	uc003cha.3	+	6	1078	c.414C>T	c.(412-414)GCC>GCT	p.A138A		NM_178339	NP_848029	Q8IVJ8	APRG1_HUMAN	AP20 region protein isoform B	138						integral to membrane				central_nervous_system(1)	1						GTGGGGATGCCTGGAAAACAA	0.473													0	0	0	0.009096	0	4	49										T	37476522	C	T	37476522	2	4	129	1	0	0	0	0	0	0	0	1	2225	668	24	2		2	C3orf35	3	37476522	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	24614930	37476522	160545908	57	38429										
XIRP1	165904	broad.mit.edu	37	chr3	39230134	39230134	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctcaaagagccagcgggcaGacctcaccgcgttgctttgg	12	13	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:39230134G>T	uc003cjk.1	-	2	1024	c.803C>A	c.(802-804)TCT>TAT	p.S268Y	XIRP1_uc003cji.2_Missense_Mutation_p.S268Y|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	268	Xin 6.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCAGCGGGCAGACCTCACCGC	0.662													1	0	1.22574e-08	0.014323	1.3213e-08	23	91										T	39230134	G	T	39230134	3	4	129	1	0	0	0	0	1	0	0	0	17426	942	33	3	4732	3	XIRP1	3	39230134	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1753612	39230134	158792296	58	38430										
CTNNB1	1499	broad.mit.edu	37	chr3	41278172	41278172	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgagctgaccagctctctctTcagaacagagccaatggctt	9	12	3	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:41278172T>A	uc010hia.1	+	14	2204	c.2048T>A	c.(2047-2049)TTC>TAC	p.F683Y	CTNNB1_uc003ckp.2_Missense_Mutation_p.F683Y|CTNNB1_uc003ckq.2_Missense_Mutation_p.F683Y|CTNNB1_uc003ckr.2_Missense_Mutation_p.F683Y|CTNNB1_uc011azf.1_Missense_Mutation_p.F676Y|CTNNB1_uc011azg.1_Missense_Mutation_p.F611Y|CTNNB1_uc003cks.2_3'UTR|CTNNB1_uc003ckt.1_3'UTR	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	683					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	AGCTCTCTCTTCAGAACAGAG	0.458		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.010729	0	11	158										A	41278172	T	A	41278172	3	1	129	1	0	0	0	0	1	0	0	0	4016	1783	62	5	2094	5	CTNNB1	3	41278172	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	2048038	41278172	156744258	59	38431										
CCR5	1234	broad.mit.edu	37	chr3	46414768	46414768	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atcatcctcctgacaatcgaTaggtacctggctgtcgtcca	8	13	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:46414768T>C	uc003cpo.3	+	3	497	c.375T>C	c.(373-375)GAT>GAC	p.D125D	CCR5_uc010hjd.2_Silent_p.D125D	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	125	Cytoplasmic (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	TGACAATCGATAGGTACCTGG	0.478													0	0	0	0.006214	0	10	209										C	46414768	T	C	46414768	2	2	129	1	0	0	0	0	0	0	0	1	2944	1403	49	5		5	CCR5	3	46414768	Silent	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	5136596	46414768	151607662	60	38432										
KLHDC8B	200942	broad.mit.edu	37	chr3	49211748	49211748	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtacgtgtgtatgagccccgTcgggactgctggctttcgct	14	11	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:49211748T>C	uc003cwh.2	+	3	638	c.453T>C	c.(451-453)CGT>CGC	p.R151R	KLHDC8B_uc003cwi.1_Silent_p.R24R	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	151	Kelch 4.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATGAGCCCCGTCGGGACTGCT	0.597													0	0	0	0.006214	0	10	117										C	49211748	T	C	49211748	2	2	129	1	0	0	0	0	0	0	0	1	8363	1654	58	5		5	KLHDC8B	3	49211748	Silent	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	2796980	49211748	148810682	61	38433										
AMIGO3	386724	broad.mit.edu	37	chr3	49756220	49756220	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcgctgtagcaggtggtagaGgcggcagtcgcaaggcaaag	18	8	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:49756220G>A	uc003cxj.2	-	1	1019	c.679C>T	c.(679-681)CTC>TTC	p.L227F	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	227	Extracellular (Potential).|LRRCT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGGTGGTAGAGGCGGCAGTCG	0.657													0	0	0	0.00308	0	8	86										A	49756220	G	A	49756220	3	1	129	1	0	0	0	0	1	0	0	0	577	1000	35	2	839	2	AMIGO3	3	49756220	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	544472	49756220	148266210	62	38434										
MAGI1	9223	broad.mit.edu	37	chr3	65365145	65365145	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctggctgccctgcggagtgCgcttctcttctgtcagcgag	13	13	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:65365145C>T	uc003dmn.2	-	17	3312	c.2786G>A	c.(2785-2787)CGC>CAC	p.R929H	MAGI1_uc003dmm.2_Missense_Mutation_p.R957H|MAGI1_uc003dmo.2_Missense_Mutation_p.R957H|MAGI1_uc003dmp.2_Missense_Mutation_p.R929H|MAGI1_uc003dmq.1_RNA|MAGI1_uc010hnx.1_Missense_Mutation_p.R240H	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	957					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CTGCGGAGTGCGCTTCTCTTC	0.453													0	0	0	0.00499	0	16	121										T	65365145	C	T	65365145	3	4	129	1	0	0	0	0	1	0	0	0	9190	768	27	2	1776	2	MAGI1	3	65365145	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	15608925	65365145	132657285	63	38435										
ROBO2	6092	broad.mit.edu	37	chr3	77600062	77600062	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcaccaacattcaacgttccGacgcgggttactacatctgc	7	14	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:77600062G>A	uc003dpy.3	+	8	1796	c.1153G>A	c.(1153-1155)GAC>AAC	p.D385N	ROBO2_uc003dpz.2_Missense_Mutation_p.D389N|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D389N	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	385	Ig-like C2-type 4.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCAACGTTCCGACGCGGGTTA	0.473													0	0	0	0.001984	0	7	74										A	77600062	G	A	77600062	3	1	129	1	0	0	0	0	1	0	0	0	13514	1058	37	1	1185	1	ROBO2	3	77600062	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	12234917	77600062	120422368	64	38436										
CCDC80	151887	broad.mit.edu	37	chr3	112358447	112358447	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gctggtctttgctcaggtctCacggcggccccattgatgtc	12	13	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:112358447C>T	uc003dzf.2	-	2	524	c.306G>A	c.(304-306)GTG>GTA	p.V102V	CCDC80_uc011bhv.1_Silent_p.V102V|CCDC80_uc003dzg.2_Silent_p.V102V|CCDC80_uc003dzh.1_Silent_p.V102V	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	102										ovary(2)	2						GCTCAGGTCTCACGGCGGCCC	0.607													0	0	0	0.005443	0	25	135										T	112358447	C	T	112358447	2	4	129	1	0	0	0	0	0	0	0	1	2854	813	29	1		1	CCDC80	3	112358447	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	34758385	112358447	85663983	65	38437										
PRR23B	389151	broad.mit.edu	37	chr3	138738765	138738765	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcgttccgggagcggcgagcGcgcgtggggacctggactcc	19	13	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:138738765G>A	uc003esy.1	-	1	1004	c.739C>T	c.(739-741)CGC>TGC	p.R247C		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	247	Pro-rich.									breast(1)	1						AGCGGCGAGCGCGCGTGGGGA	0.657													0	0	0	0.010729	0	12	84										A	138738765	G	A	138738765	3	1	129	1	0	0	0	0	1	0	0	0	12595	1087	38	2	62	2	PRR23B	3	138738765	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	26380318	138738765	59283665	66	38438										
LRRIQ4	344657	broad.mit.edu	37	chr3	169540297	169540297	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctggaaatcattgacctggaCgagaacaaaataggtgccat	10	8	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:169540297C>T	uc003fgb.2	+	1	588	c.588C>T	c.(586-588)GAC>GAT	p.D196D		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	196	LRR 8.										0						TTGACCTGGACGAGAACAAAA	0.517													0	0	0	0.010729	0	12	142										T	169540297	C	T	169540297	2	4	129	1	0	0	0	0	0	0	0	1	9031	535	19	2		2	LRRIQ4	3	169540297	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	30801532	169540297	28482133	67	38439										
C3orf43	255798	broad.mit.edu	37	chr3	196234952	196234952	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cactttagcagtatagtgttCtgccttgttaccacgtgcaa	8	10	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr3:196234952C>T	uc003fws.2	-	3	608	c.451G>A	c.(451-453)GAA>AAA	p.E151K	C3orf43_uc003fwr.2_Missense_Mutation_p.E143K	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	151						integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		GTATAGTGTTCTGCCTTGTTA	0.463													0	0	0	0.013537	0	13	105										T	196234952	C	T	196234952	3	4	129	1	0	0	0	0	1	0	0	0	2230	922	32	1	197	1	C3orf43	3	196234952	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	26694655	196234952	1787478	68	38440										
FGFRL1	53834	broad.mit.edu	37	chr4	1019074	1019074	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccacacacacacacacacacActctcacacacactcacacg	1	21	2	0	rs77570255		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:1019074A>T	uc003gce.2	+	7	1615	c.1454A>T	c.(1453-1455)CAC>CTC	p.H485L	FGFRL1_uc003gcf.2_Missense_Mutation_p.H485L|FGFRL1_uc003gcg.2_Missense_Mutation_p.H485L|FGFRL1_uc010ibo.2_Missense_Mutation_p.H485L	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	485	His-rich.|Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			acacacacacactctcacaca	0.483													0	0	0	0.004672	0	3	16										T	1019074	A	T	1019074	3	4	129	1	0	0	0	0	1	0	0	0	5869	159	6	5	1476	5	FGFRL1	4	1019074	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08		1019074	190135202	69	38441										
KLB	152831	broad.mit.edu	37	chr4	39448824	39448824	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttctgcgcgctcaaccacttCaccactaggttcgtgatgca	8	14	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:39448824C>T	uc003gua.2	+	4	2575	c.2478C>T	c.(2476-2478)TTC>TTT	p.F826F	KLB_uc011byj.1_Silent_p.F817F	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	826	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						TCAACCACTTCACCACTAGGT	0.657													0	0	0	0.010504	0	21	90										T	39448824	C	T	39448824	2	4	129	1	0	0	0	0	0	0	0	1	8332	825	29	1		1	KLB	4	39448824	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	38429750	39448824	151705452	70	38442										
LRRC66	339977	broad.mit.edu	37	chr4	52861415	52861415	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgtgcttctgcatgtgttagCattttacagagggaagctgt	12	6	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:52861415C>T	uc003gzi.2	-	4	1786	c.1773G>A	c.(1771-1773)ATG>ATA	p.M591I		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	591						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CATGTGTTAGCATTTTACAGA	0.483													0	0	0	0.013537	0	13	172										T	52861415	C	T	52861415	3	4	129	1	0	0	0	0	1	0	0	0	9018	710	25	2	873	2	LRRC66	4	52861415	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	13412591	52861415	138292861	71	38443										
LRRC66	339977	broad.mit.edu	37	chr4	52861829	52861829	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acccagaaaggggtctggttCtcgtagaggcttagatgagg	15	7	2	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:52861829C>T	uc003gzi.2	-	4	1372	c.1359G>A	c.(1357-1359)GAG>GAA	p.E453E		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	453						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GGGTCTGGTTCTCGTAGAGGC	0.542													0	0	0	0.008291	0	11	115										T	52861829	C	T	52861829	2	4	129	1	0	0	0	0	0	0	0	1	9018	912	32	1		1	LRRC66	4	52861829	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	414	52861829	138292447	72	38444										
IGJ	3512	broad.mit.edu	37	chr4	71527924	71527924	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aacaagaacaatcctttcatCttcttgggcttgaaaggtaa	7	8	3	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:71527924C>T	uc003hfn.3	-	2	214	c.73G>A	c.(73-75)GAT>AAT	p.D25N	IGJ_uc010ihz.2_Missense_Mutation_p.D41N	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	25					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			ATCCTTTCATCTTCTTGGGCT	0.358													0	0	0	0.008291	0	11	68										T	71527924	C	T	71527924	3	4	129	1	0	0	0	0	1	0	0	0	7592	913	32	1	418	1	IGJ	4	71527924	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	18666095	71527924	119626352	73	38445										
SMARCAD1	56916	broad.mit.edu	37	chr4	95170811	95170811	+	Nonsense_Mutation	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tttctccccattagggagagGaatcaaatgagtctgcagaa	10	8	3	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:95170811G>T	uc003htc.3	+	7	967	c.712G>T	c.(712-714)GAA>TAA	p.E238*	SMARCAD1_uc003htb.3_Nonsense_Mutation_p.E238*|SMARCAD1_uc003htd.3_Nonsense_Mutation_p.E238*|SMARCAD1_uc010ila.2_Nonsense_Mutation_p.E101*	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	238					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTAGGGAGAGGAATCAAATGA	0.323													1	0	1.06961e-07	0.00308	1.1414e-07	8	44										T	95170811	G	T	95170811	4	4	129	1	0	0	0	0	0	1	0	0	14772	1175	41	3	734	3	SMARCAD1	4	95170811	Nonsense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	23642887	95170811	95983465	74	38446										
BANK1	55024	broad.mit.edu	37	chr4	102946423	102946423	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggcagagtgcagatggagctGaggcaaatgaaatggaaggg	18	4	0	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:102946423G>C	uc003hvy.3	+	9	1625	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	BANK1_uc003hvx.3_Missense_Mutation_p.E436Q|BANK1_uc010ill.2_Missense_Mutation_p.E318Q|BANK1_uc003hvz.3_Missense_Mutation_p.E421Q	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	451					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		AGATGGAGCTGAGGCAAATGA	0.453													0	0	0	0.001855	0	14	118										C	102946423	G	C	102946423	3	2	129	1	0	0	0	0	1	0	0	0	1309	1291	45	1	1385	1	BANK1	4	102946423	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	7775612	102946423	88207853	75	38447										
FAT4	79633	broad.mit.edu	37	chr4	126240575	126240575	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaccaactctcttatgaagtCaccctttctgagtcagaacc	6	13	4	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:126240575C>T	uc003ifj.3	+	1	3009	c.3009C>T	c.(3007-3009)GTC>GTT	p.V1003V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1003	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTTATGAAGTCACCCTTTCTG	0.408													0	0	0	0.004482	0	7	93										T	126240575	C	T	126240575	2	4	129	1	0	0	0	0	0	0	0	1	5692	813	29	1		1	FAT4	4	126240575	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	23294152	126240575	64913701	76	38448										
FAT4	79633	broad.mit.edu	37	chr4	126411502	126411502	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgtgggctgtgcctgccatcGtgggcagctgcgcaaccgtc	15	13	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:126411502G>A	uc003ifj.3	+	17	13525	c.13525G>A	c.(13525-13527)GTG>ATG	p.V4509M	FAT4_uc011cgp.1_Missense_Mutation_p.V2750M|FAT4_uc003ifi.1_Missense_Mutation_p.V1986M	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4509	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCCTGCCATCGTGGGCAGCTG	0.577													0	0	0	0.006214	0	10	111										A	126411502	G	A	126411502	3	1	129	1	0	0	0	0	1	0	0	0	5692	1145	40	2	13591	2	FAT4	4	126411502	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	170927	126411502	64742774	77	38449										
LRBA	987	broad.mit.edu	37	chr4	151771906	151771906	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctgtatatctgtttctattGaaaataatagatcagtgagc	7	5	4	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:151771906G>A	uc010ipj.2	-	24	4448	c.3974C>T	c.(3973-3975)TCA>TTA	p.S1325L	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Missense_Mutation_p.S1325L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1325	WD 1.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGTTTCTATTGAAAATAATAG	0.343													0	0	0	0.000602	0	5	23										A	151771906	G	A	151771906	3	1	129	1	0	0	0	0	1	0	0	0	8931	1294	45	1	4757	1	LRBA	4	151771906	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	25360404	151771906	39382370	78	38450										
FBXW7	55294	broad.mit.edu	37	chr4	153244185	153244185	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctccaatgtgactaggtttcGaataaattcacccgttttca	6	10	2	1	rs144247898		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:153244185G>A	uc003ims.2	-	12	2121	c.1972C>T	c.(1972-1974)CGA>TGA	p.R658*	FBXW7_uc011cii.1_Nonsense_Mutation_p.R658*|FBXW7_uc003imt.2_Nonsense_Mutation_p.R658*|FBXW7_uc011cih.1_Nonsense_Mutation_p.R482*|FBXW7_uc003imq.2_Nonsense_Mutation_p.R578*|FBXW7_uc003imr.2_Nonsense_Mutation_p.R540*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	658	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R658*(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTAGGTTTCGAATAAATTCA	0.473			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.004482	0	8	121										A	153244185	G	A	153244185	4	1	129	1	0	0	0	0	0	1	0	0	5769	1066	37	1	155	1	FBXW7	4	153244185	Nonsense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1472279	153244185	37910091	79	38451										
FBXW7	55294	broad.mit.edu	37	chr4	153247165	153247165	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	taagagatcttacctgtaatGaatagactctattagtatgc	7	6	2	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr4:153247165G>A	uc003ims.2	-	10	1786	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	FBXW7_uc011cii.1_Missense_Mutation_p.S546L|FBXW7_uc003imt.2_Missense_Mutation_p.S546L|FBXW7_uc011cih.1_Missense_Mutation_p.S370L|FBXW7_uc003imq.2_Missense_Mutation_p.S466L|FBXW7_uc003imr.2_Missense_Mutation_p.S428L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	546	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTGTAATGAATAGACTCT	0.398			Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.001855	0	13	86										A	153247165	G	A	153247165	3	1	129	1	0	0	0	0	1	0	0	0	5769	1294	45	1	498	1	FBXW7	4	153247165	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2980	153247165	37907111	80	38452										
RNASEN	29102	broad.mit.edu	37	chr5	31521263	31521263	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tatactcttttttgtaggacCtttccagagatggtgatctt	8	7	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:31521263C>G	uc003jhg.2	-	5	1273	c.914G>C	c.(913-915)AGG>ACG	p.R305T	RNASEN_uc003jhh.2_Missense_Mutation_p.R305T|RNASEN_uc003jhi.2_Missense_Mutation_p.R305T|RNASEN_uc010iui.1_Intron	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	305	Arg-rich.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TTTGTAGGACCTTTCCAGAGA	0.408													0	0	0	0.001855	0	12	154										G	31521263	C	G	31521263	3	3	129	1	0	0	0	0	1	0	0	0	13417	681	24	4	3334	4	RNASEN	5	31521263	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		31521263	149393997	81	38453										
GOLPH3	64083	broad.mit.edu	37	chr5	32143969	32143969	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccagatgatatacagtcattCcaaaatgatgtgtaacccta	6	9	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:32143969C>A	uc003jhp.1	-	2	528	c.243G>T	c.(241-243)TGG>TGT	p.W81C		NM_022130	NP_071413	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3	81					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			ovary(1)	1						TACAGTCATTCCAAAATGATG	0.318													1	0	1.06961e-07	0.00308	1.1414e-07	8	68										A	32143969	C	A	32143969	3	1	129	1	0	0	0	0	1	0	0	0	6568	856	30	3	665	3	GOLPH3	5	32143969	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	622706	32143969	148771291	82	38454										
WDR70	55100	broad.mit.edu	37	chr5	37727078	37727078	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaccgatgacagtaatcctcGggaagccattttgcgtcatg	11	10	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:37727078G>A	uc003jkv.2	+	17	1866	c.1808G>A	c.(1807-1809)CGG>CAG	p.R603Q		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	603										ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTAATCCTCGGGAAGCCATT	0.463													0	0	0	0.00308	0	8	91										A	37727078	G	A	37727078	3	1	129	1	0	0	0	0	1	0	0	0	17318	1116	39	2	1874	2	WDR70	5	37727078	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	5583109	37727078	143188182	83	38455										
IQGAP2	10788	broad.mit.edu	37	chr5	75902129	75902129	+	Splice_Site	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aattcaagaagaaaatgaccGtaagtataagacactttcct	6	7	1	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:75902129G>A	uc003kek.2	+	12	1579	c.1357_splice	c.e12+1	p.R453_splice	IQGAP2_uc010izv.2_5'Flank|IQGAP2_uc011csv.1_5'Flank|IQGAP2_uc003kel.2_5'Flank	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAAAATGACCGTAAGTATAAG	0.348													0	0	0	0.004672	0	3	35										A	75902129	G	A	75902129	5	1	129	1	0	0	0	0	0	0	1	0	7815	1159	40	2	1404	2	IQGAP2	5	75902129	Splice_Site	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	38175051	75902129	105013131	84	38456										
PPIP5K2	23262	broad.mit.edu	37	chr5	102518935	102518935	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gccccctttctcacttccagGaagagagccccctgagtgtg	10	15	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:102518935G>A	uc003kod.3	+	25	3442	c.2923G>A	c.(2923-2925)GAA>AAA	p.E975K	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.E975K|PPIP5K2_uc003kof.2_Intron	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	975					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						TCACTTCCAGGAAGAGAGCCC	0.443													0	0	0	0.001168	0	6	36										A	102518935	G	A	102518935	3	1	129	1	0	0	0	0	1	0	0	0	12333	1188	41	1	3017	1	PPIP5K2	5	102518935	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	26616806	102518935	78396325	85	38457										
SHROOM1	134549	broad.mit.edu	37	chr5	132160002	132160002	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	caccccctgccagcagtcatCtgcccctgcagttcctggac	8	19	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:132160002C>G	uc003kxx.2	-	7	2156	c.1351G>C	c.(1351-1353)GAT>CAT	p.D451H	SHROOM1_uc003kxy.1_Missense_Mutation_p.D451H	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	451					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGCAGTCATCTGCCCCTGCA	0.557													0	0	0	0.001168	0	6	38										G	132160002	C	G	132160002	3	3	129	1	0	0	0	0	1	0	0	0	14293	913	32	1	1223	1	SHROOM1	5	132160002	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	29641067	132160002	48755258	86	38458										
PCDHA1	56147	broad.mit.edu	37	chr5	140167320	140167320	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cacggtgtctgcgcgggacgCggacgcgcaggagaacgcgc	18	13	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:140167320C>T	uc003lhb.2	+	1	1445	c.1445C>T	c.(1444-1446)GCG>GTG	p.A482V	PCDHA1_uc003lha.2_Missense_Mutation_p.A482V|PCDHA1_uc003lgz.2_Missense_Mutation_p.A482V	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGGACGCGGACGCGCAG	0.657													0	0	0	0.010729	0	9	173										T	140167320	C	T	140167320	3	4	129	1	0	0	0	0	1	0	0	0	11519	768	27	2	1447	2	PCDHA1	5	140167320	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	8007318	140167320	40747940	87	38459										
PCDHA9	9752	broad.mit.edu	37	chr5	140230132	140230132	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcatcgtcgcgggcgtcagtGggtgccacgggccccgaggt	17	13	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:140230132G>T	uc003lhu.2	+	1	2776	c.2052G>T	c.(2050-2052)GTG>GTT	p.V684V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.V684V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	684	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGTCAGTGGGTGCCACGG	0.652													1	0	3.28513e-13	0.003954	3.60231e-13	26	117										T	140230132	G	T	140230132	2	4	129	1	0	0	0	0	0	0	0	1	11531	1335	47	4		4	PCDHA9	5	140230132	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	62812	140230132	40685128	88	38460										
ARAP3	64411	broad.mit.edu	37	chr5	141050834	141050834	+	Nonsense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggcacttgggggaatgacctGagggcaagaggccagggcag	19	8	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:141050834G>C	uc003llm.2	-	13	2066	c.1988C>G	c.(1987-1989)TCA>TGA	p.S663*	ARAP3_uc011dbe.1_Nonsense_Mutation_p.S325*|ARAP3_uc003lln.2_Intron	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	663					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						GGAATGACCTGAGGGCAAGAG	0.572													0	0	0	0.004007	0	13	71										C	141050834	G	C	141050834	4	2	129	1	0	0	0	0	0	1	0	0	840	1294	45	1	2730	1	ARAP3	5	141050834	Nonsense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	820702	141050834	39864426	89	38461										
LARS	51520	broad.mit.edu	37	chr5	145512562	145512562	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctacccaggtgtacagacgGagaatacctgcatctgccat	9	12	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:145512562G>T	uc003lnx.1	-	23	2533	c.2295C>A	c.(2293-2295)CTC>CTA	p.L765L	LARS_uc003lnw.1_5'Flank|LARS_uc011dbq.1_Silent_p.L719L|LARS_uc011dbr.1_Silent_p.L711L|LARS_uc011dbs.1_Silent_p.L738L	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	765					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TGTACAGACGGAGAATACCTG	0.478													1	0	2.0095e-06	0.001984	2.12299e-06	7	56										T	145512562	G	T	145512562	2	4	129	1	0	0	0	0	0	0	0	1	8634	1161	41	3		3	LARS	5	145512562	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	4461728	145512562	35402698	90	38462										
GABRB2	2561	broad.mit.edu	37	chr5	160757993	160757993	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	caaagaagatgtagttgactAgggcatattccagaagggcc	12	7	0	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:160757993A>G	uc003lys.1	-	9	1192	c.974T>C	c.(973-975)CTA>CCA	p.L325P	GABRB2_uc011deh.1_Missense_Mutation_p.L164P|GABRB2_uc003lyr.1_Missense_Mutation_p.L325P|GABRB2_uc003lyt.1_Missense_Mutation_p.L325P|GABRB2_uc010jiu.1_Missense_Mutation_p.L262P	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	325	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GTAGTTGACTAGGGCATATTC	0.512													0	0	0	0.008871	0	21	93										G	160757993	A	G	160757993	3	3	129	1	0	0	0	0	1	0	0	0	6167	420	15	5	576	5	GABRB2	5	160757993	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	15245431	160757993	20157267	91	38463										
ODZ2	57451	broad.mit.edu	37	chr5	167645734	167645734	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gagcctggtgacaggggagtActtgtacaatttcacatata	11	7	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr5:167645734A>G	uc010jjd.2	+	23	4811	c.4811A>G	c.(4810-4812)TAC>TGC	p.Y1604C	ODZ2_uc003lzr.3_Missense_Mutation_p.Y1374C|ODZ2_uc003lzt.3_Missense_Mutation_p.Y977C|ODZ2_uc010jje.2_Missense_Mutation_p.Y868C	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACAGGGGAGTACTTGTACAAT	0.473													0	0	0	0.010729	0	12	124										G	167645734	A	G	167645734	3	3	129	1	0	0	0	0	1	0	0	0	10835	391	14	5	4901	5	ODZ2	5	167645734	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	6887741	167645734	13269526	92	38464										
FOXQ1	94234	broad.mit.edu	37	chr6	1313431	1313431	+	Silent	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggcagctacacgggctggcgCaactccgtgcgccacaacct	12	16	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:1313431C>A	uc003mtl.3	+	1	757	c.492C>A	c.(490-492)CGC>CGA	p.R164R		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	164	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		CGGGCTGGCGCAACTCCGTGC	0.647													1	0	0.000442599	0.006214	0.000456969	9	92										A	1313431	C	A	1313431	2	1	129	1	0	0	0	0	0	0	0	1	6030	697	25	4		4	FOXQ1	6	1313431	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		1313431	169801636	93	38465										
CDYL	9425	broad.mit.edu	37	chr6	4892403	4892403	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cagtggacggctttcagagcGagagccctgagaaactggac	14	10	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:4892403G>A	uc003mwi.2	+	4	774	c.643G>A	c.(643-645)GAG>AAG	p.E215K	CDYL_uc003mwj.2_Missense_Mutation_p.E161K|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_Missense_Mutation_p.E29K|CDYL_uc011dhy.1_Missense_Mutation_p.E29K	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	215					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CTTTCAGAGCGAGAGCCCTGA	0.602													0	0	0	0.000602	0	5	70										A	4892403	G	A	4892403	3	1	129	1	0	0	0	0	1	0	0	0	3185	1059	37	1	487	1	CDYL	6	4892403	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3578972	4892403	166222664	94	38466										
MUTED	63915	broad.mit.edu	37	chr6	8041460	8041460	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtttcatggatcatgttcttCaaattttcaagaactcgcat	6	8	5	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:8041460C>T	uc003mxy.2	-	3	275	c.237G>A	c.(235-237)TTG>TTA	p.L79L	TXNDC5_uc003mxw.2_5'UTR|MUTED_uc010joc.2_Silent_p.L15L|MUTED_uc010job.2_RNA	NM_201280	NP_958437	Q8TDH9	MUTED_HUMAN	muted	79						BLOC-1 complex	protein binding				0	Ovarian(93;0.0398)					TCATGTTCTTCAAATTTTCAA	0.353													0	0	0	0.006214	0	10	58										T	8041460	C	T	8041460	2	4	129	1	0	0	0	0	0	0	0	1	9992	825	29	1		1	MUTED	6	8041460	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	3149057	8041460	163073607	95	38467										
SCAND3	114821	broad.mit.edu	37	chr6	28547168	28547168	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggatcatttcttccatagaaActtcctgcccatatgtgccc	6	13	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:28547168A>T	uc003nlo.2	-	2	1067	c.449T>A	c.(448-450)GTT>GAT	p.V150D		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	150					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTCCATAGAAACTTCCTGCCC	0.413													0	0	0	0.001855	0	12	93										T	28547168	A	T	28547168	3	4	129	1	0	0	0	0	1	0	0	0	13876	43	2	5	3540	5	SCAND3	6	28547168	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	20505708	28547168	142567899	96	38468										
C6orf15	29113	broad.mit.edu	37	chr6	31079947	31079947	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttagacctagggtccagagcGggctgcggatgttcagagtt	15	8	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:31079947G>A	uc003nsk.1	-	2	189	c.189C>T	c.(187-189)CCC>CCT	p.P63P	PSORS1C1_uc003nsl.1_5'Flank|PSORS1C1_uc010jsj.1_5'Flank	NM_014070	NP_054789	Q6UXA7	CF015_HUMAN	STG protein precursor	63											0						GGTCCAGAGCGGGCTGCGGAT	0.562													0	0	0	0.00499	0	18	141										A	31079947	G	A	31079947	2	1	129	1	0	0	0	0	0	0	0	1	2336	1103	39	2		2	C6orf15	6	31079947	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2532779	31079947	140035120	97	38469										
LY6G5B	58496	broad.mit.edu	37	chr6	31639913	31639913	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccaatttccatgctgggacgGagcctgatggcctggacccc	12	14	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:31639913G>C	uc003nvt.1	+	3	460	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	CSNK2B_uc003nvs.1_3'UTR	NM_021221	NP_067044	Q8NDX9	LY65B_HUMAN	lymphocyte antigen 6 complex G5B precursor	154						extracellular region					0						TGCTGGGACGGAGCCTGATGG	0.587													0	0	0	0.008291	0	10	74										C	31639913	G	C	31639913	3	2	129	1	0	0	0	0	1	0	0	0	9092	1175	41	1	470	1	LY6G5B	6	31639913	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	559966	31639913	139475154	98	38470										
RPS18	6222	broad.mit.edu	37	chr6	33243657	33243657	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcgggagaactcactgaggaTgaggtgaggacaaggaaggg	19	5	1	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:33243657T>C	uc003odp.1	+	3	231	c.186T>C	c.(184-186)GAT>GAC	p.D62D	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	62					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						TCACTGAGGATGAGGTGAGGA	0.567													0	0	0	0.001168	0	6	136										C	33243657	T	C	33243657	2	2	129	1	0	0	0	0	0	0	0	1	13628	1461	51	5		5	RPS18	6	33243657	Silent	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	1603744	33243657	137871410	99	38471										
TCP11	6954	broad.mit.edu	37	chr6	35088699	35088699	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tacatactaggctgcttattGaggagttcctggaatttagc	10	7	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:35088699G>C	uc003okd.2	-	6	922	c.741C>G	c.(739-741)CTC>CTG	p.L247L	TCP11_uc003ojz.1_Silent_p.L172L|TCP11_uc003oka.2_Silent_p.L172L|TCP11_uc003okb.2_Silent_p.L171L|TCP11_uc003okc.2_Silent_p.L171L|TCP11_uc011dsu.1_Silent_p.L229L|TCP11_uc011dsv.1_Silent_p.L196L|TCP11_uc011dsw.1_Silent_p.L201L	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	234					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						GCTGCTTATTGAGGAGTTCCT	0.423													0	0	0	0.01441	0	69	392										C	35088699	G	C	35088699	2	2	129	1	0	0	0	0	0	0	0	1	15710	1277	45	1		1	TCP11	6	35088699	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1845042	35088699	136026368	100	38472										
PPARD	5467	broad.mit.edu	37	chr6	35387983	35387983	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggggcctcatgcggcagcctCaacatggagtgccgggtgtg	17	11	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:35387983C>G	uc003okm.2	+	4	519	c.210C>G	c.(208-210)CTC>CTG	p.L70L	PPARD_uc003okl.2_Silent_p.L70L|PPARD_uc003okn.2_Silent_p.L70L|PPARD_uc011dtb.1_Silent_p.L31L|PPARD_uc011dtc.1_Intron|PPARD_uc010jvv.1_Intron	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	70					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	GCGGCAGCCTCAACATGGAGT	0.652													0	0	0	0.013537	0	12	71										G	35387983	C	G	35387983	2	3	129	1	0	0	0	0	0	0	0	1	12298	813	29	1		1	PPARD	6	35387983	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	299284	35387983	135727084	101	38473										
TFAP2D	83741	broad.mit.edu	37	chr6	50696937	50696937	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aagaatgggggccgctgcctGagagagaaattggataggct	16	6	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:50696937G>C	uc003paf.2	+	5	1307	c.795G>C	c.(793-795)CTG>CTC	p.L265L	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	265							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					GCCGCTGCCTGAGAGAGAAAT	0.408													0	0	0	0.013537	0	13	124										C	50696937	G	C	50696937	2	2	129	1	0	0	0	0	0	0	0	1	15787	1277	45	1		1	TFAP2D	6	50696937	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	15308954	50696937	120418130	102	38474										
GRIK2	2898	broad.mit.edu	37	chr6	102337572	102337572	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atgttcgagagaaggtcatcGacttttccaagccctttatg	9	9	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:102337572G>A	uc003pqp.3	+	11	1831	c.1582G>A	c.(1582-1584)GAC>AAC	p.D528N	GRIK2_uc003pqn.2_Missense_Mutation_p.D528N|GRIK2_uc003pqo.3_Missense_Mutation_p.D528N|GRIK2_uc010kcw.2_Missense_Mutation_p.D528N	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	528	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GAAGGTCATCGACTTTTCCAA	0.408													0	0	0	0.00245	0	14	124										A	102337572	G	A	102337572	3	1	129	1	0	0	0	0	1	0	0	0	6774	1058	37	1	1624	1	GRIK2	6	102337572	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	51640635	102337572	68777495	103	38475										
FAM184A	79632	broad.mit.edu	37	chr6	119300685	119300685	+	Splice_Site	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtaaatgattttcaagagccTagaacaagacaaattcaaat	6	6	2	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:119300685T>C	uc003pyj.2	-	11	2650	c.2302_splice	c.e11-1	p.A768_splice	FAM184A_uc003pyk.3_Splice_Site_p.A648_splice|FAM184A_uc003pyl.3_Splice_Site_p.A648_splice	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1											ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TTCAAGAGCCTAGAACAAGAC	0.328													0	0	0	0.009096	0	4	31										C	119300685	T	C	119300685	5	2	129	1	0	0	0	0	0	0	1	0	5511	1536	53	5	1154	5	FAM184A	6	119300685	Splice_Site	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	16963113	119300685	51814382	104	38476										
TAAR8	83551	broad.mit.edu	37	chr6	132874511	132874511	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcttatagctaaacaacaagCtataaaaattgaaactacta	3	7	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:132874511C>A	uc011ecj.1	+	1	680	c.680C>A	c.(679-681)GCT>GAT	p.A227D		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	227	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		AAACAACAAGCTATAAAAATT	0.358													1	0	3.86212e-05	0.008291	4.01358e-05	11	77										A	132874511	C	A	132874511	3	1	129	1	0	0	0	0	1	0	0	0	15490	797	28	4	682	4	TAAR8	6	132874511	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	13573826	132874511	38240556	105	38477										
TMEM181	57583	broad.mit.edu	37	chr6	159046150	159046150	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcctagggaatgaaggtcttCttcatggtggtggcagcggt	15	7	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr6:159046150C>T	uc003qrm.3	+	12	1391	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F	TMEM181_uc010kjr.1_Silent_p.F291F	NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	460	Helical; (Potential).				pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		TGAAGGTCTTCTTCATGGTGG	0.547													0	0	0	0.00308	0	8	153										T	159046150	C	T	159046150	2	4	129	1	0	0	0	0	0	0	0	1	16097	912	32	1		1	TMEM181	6	159046150	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	26171639	159046150	12068917	106	38478										
C7orf50	84310	broad.mit.edu	37	chr7	1037332	1037332	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggggggatcagagccctcctCatccagctcccgcatcaggg	13	15	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:1037332C>T	uc003sju.2	-	5	584	c.514G>A	c.(514-516)GAG>AAG	p.E172K	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Missense_Mutation_p.E172K|C7orf50_uc011jvu.1_Missense_Mutation_p.E172K	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	172							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GAGCCCTCCTCATCCAGCTCC	0.711													0	0	0	0.004482	0	8	80										T	1037332	C	T	1037332	3	4	129	1	0	0	0	0	1	0	0	0	2399	835	29	1	74	1	C7orf50	7	1037332	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		1037332	158101331	107	38479										
FTSJ2	29960	broad.mit.edu	37	chr7	2274900	2274900	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cctctgtaaccgacggctttGacttccagcccaggttttac	8	14	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:2274900G>C	uc003slm.2	-	3	627	c.598C>G	c.(598-600)CAA>GAA	p.Q200E	MAD1L1_uc003slh.1_5'Flank|MAD1L1_uc003slf.1_5'Flank|MAD1L1_uc003slg.1_5'Flank|MAD1L1_uc010ksh.1_5'Flank|MAD1L1_uc003sli.1_5'Flank|MAD1L1_uc010ksi.1_5'Flank|MAD1L1_uc010ksj.2_5'Flank|FTSJ2_uc003slk.2_Missense_Mutation_p.Q46E|FTSJ2_uc003sll.2_Missense_Mutation_p.Q46E|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_Missense_Mutation_p.Q46E	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	200					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		CGACGGCTTTGACTTCCAGCC	0.507													0	0	0	0.00245	0	15	105										C	2274900	G	C	2274900	3	2	129	1	0	0	0	0	1	0	0	0	6088	1299	45	1	146	1	FTSJ2	7	2274900	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1237568	2274900	156863763	108	38480										
DNAH11	8701	broad.mit.edu	37	chr7	21920404	21920404	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tccacgcctgtgttgctgggAgactgaggtttggcccccag	14	12	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:21920404A>G	uc003svc.2	+	76	12332	c.12301A>G	c.(12301-12303)AGA>GGA	p.R4101G		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4101	AAA 6 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TGTTGCTGGGAGACTGAGGTT	0.478									Kartagener_syndrome				0	0	0	0.008291	0	11	120										G	21920404	A	G	21920404	3	3	129	1	0	0	0	0	1	0	0	0	4599	296	11	5	12600	5	DNAH11	7	21920404	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	19645504	21920404	137218259	109	38481										
EGFR	1956	broad.mit.edu	37	chr7	55259449	55259449	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggaccgtcgcttggtgcaccGcgacctggcagccaggaacg	15	14	0	0	rs146121458		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:55259449G>A	uc003tqk.2	+	21	2753	c.2507G>A	c.(2506-2508)CGC>CAC	p.R836H	EGFR_uc010kzg.1_Missense_Mutation_p.R791H|EGFR_uc011kco.1_Missense_Mutation_p.R783H|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	836	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.R836C(2)|p.R836R(1)|p.R836S(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TTGGTGCACCGCGACCTGGCA	0.537		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			0	0	0	0.008291	0	10	117										A	55259449	G	A	55259449	3	1	129	1	0	0	0	0	1	0	0	0	4967	1087	38	2	2853	2	EGFR	7	55259449	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	33339045	55259449	103879214	110	38482										
TPST1	8460	broad.mit.edu	37	chr7	65705842	65705842	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccatgcaagccttcttactaGaaattatcgttaagcatggg	8	9	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:65705842G>A	uc003tuw.2	+	2	782	c.430G>A	c.(430-432)GAA>AAA	p.E144K	TPST1_uc010kzy.2_Intron|TPST1_uc010kzz.2_Missense_Mutation_p.E144K|TPST1_uc010laa.2_Missense_Mutation_p.E144K	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	144	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						CTTCTTACTAGAAATTATCGT	0.438													0	0	0	0.009096	0	4	86										A	65705842	G	A	65705842	3	1	129	1	0	0	0	0	1	0	0	0	16424	943	33	1	432	1	TPST1	7	65705842	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	10446393	65705842	93432821	111	38483										
PCLO	27445	broad.mit.edu	37	chr7	82784366	82784366	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgctgagccaggctgttgagAtgggggttttgttgagccag	17	6	0	3	rs112239934		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:82784366A>G	uc003uhx.2	-	2	1880	c.1591T>C	c.(1591-1593)TCT>CCT	p.S531P	PCLO_uc003uhv.2_Missense_Mutation_p.S531P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	477	Gln-rich.|Pro-rich.|10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGCTGTTGAGATGGGGGTTTT	0.557													0	0	0	0.008291	0	8	357										G	82784366	A	G	82784366	3	3	129	1	0	0	0	0	1	0	0	0	11583	333	12	5	13950	5	PCLO	7	82784366	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	17078524	82784366	76354297	112	38484										
AKAP9	10142	broad.mit.edu	37	chr7	91691704	91691704	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtgcaagtaacaggttgcaaGaattggaggcagagcaacag	14	6	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:91691704G>C	uc003ulg.2	+	24	6106	c.5881G>C	c.(5881-5883)GAA>CAA	p.E1961Q	AKAP9_uc003ulf.2_Missense_Mutation_p.E1961Q|AKAP9_uc003uli.2_Missense_Mutation_p.E1584Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1973	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGGTTGCAAGAATTGGAGGC	0.403			T	BRAF	papillary thyroid								0	0	0	0.004482	0	9	120										C	91691704	G	C	91691704	3	2	129	1	0	0	0	0	1	0	0	0	459	943	33	1	5975	1	AKAP9	7	91691704	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	8907338	91691704	67446959	113	38485										
GIGYF1	64599	broad.mit.edu	37	chr7	100281007	100281007	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctggcggcgcttctcctctcGacgcttgcgttcctcttcct	9	17	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr7:100281007G>C	uc003uwg.1	-	18	3122	c.2113C>G	c.(2113-2115)CGA>GGA	p.R705G		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	705										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTCTCCTCTCGACGCTTGCGT	0.647													0	0	0	0.004656	0	27	245										C	100281007	G	C	100281007	3	2	129	1	0	0	0	0	1	0	0	0	6377	1066	37	1	1022	1	GIGYF1	7	100281007	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	8589303	100281007	58857656	114	38486										
STMN4	81551	broad.mit.edu	37	chr8	27099982	27099982	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agcagaacaaggacaccagcGggagctccttcatcttctct	9	13	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:27099982G>A	uc003xfk.2	-	3	155	c.41C>T	c.(40-42)CCG>CTG	p.P14L	STMN4_uc003xfj.2_Missense_Mutation_p.P14L|STMN4_uc011lai.1_Missense_Mutation_p.P14L|STMN4_uc011laj.1_Missense_Mutation_p.P5L|STMN4_uc011lak.1_Missense_Mutation_p.P14L|STMN4_uc010luo.2_Missense_Mutation_p.P14L			Q9H169	STMN4_HUMAN	RecName: Full=Stathmin-4; AltName: Full=Stathmin-like protein B3;          Short=RB3;	14					intracellular signal transduction					large_intestine(1)|pancreas(1)	2		Ovarian(32;0.00167)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0214)|Epithelial(17;9.82e-10)|Colorectal(74;0.142)		GGACACCAGCGGGAGCTCCTT	0.567													0	0	0	0.004482	0	9	47										A	27099982	G	A	27099982	3	1	129	1	0	0	0	0	1	0	0	0	15310	1116	39	2	629	2	STMN4	8	27099982	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08		27099982	119264040	115	38487										
MYST3	7994	broad.mit.edu	37	chr8	41790659	41790659	+	Silent	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggctgctgctggggagggggTgggggtggaggctgctgggg	27	5	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:41790659T>G	uc010lxb.2	-	18	5623	c.5079A>C	c.(5077-5079)CCA>CCC	p.P1693P	MYST3_uc010lxc.2_Silent_p.P1693P|MYST3_uc003xon.3_Silent_p.P1693P	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1693	Gln/Pro-rich.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			ggggagggggtgggggtggag	0.164													0	0	0	0.001855	0	5	17										G	41790659	T	G	41790659	2	3	129	1	0	0	0	0	0	0	0	1	10104	1683	59	5		5	MYST3	8	41790659	Silent	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	14690677	41790659	104573363	116	38488										
AP3M2	10947	broad.mit.edu	37	chr8	42023048	42023048	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccctcctgatggaaacttccGcctgctgtcttaccatgtca	7	15	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:42023048G>T	uc003xop.2	+	7	1064	c.773G>T	c.(772-774)CGC>CTC	p.R258L	AP3M2_uc003xoo.2_Missense_Mutation_p.R258L|AP3M2_uc010lxe.2_RNA|AP3M2_uc003xoq.1_Missense_Mutation_p.R143L|AP3M2_uc003xor.1_Missense_Mutation_p.R258L	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	258	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GGAAACTTCCGCCTGCTGTCT	0.448													1	0	2.61681e-11	0.00245	2.84009e-11	14	216										T	42023048	G	T	42023048	3	4	129	1	0	0	0	0	1	0	0	0	748	1087	38	4	791	4	AP3M2	8	42023048	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	232389	42023048	104340974	117	38489										
PLAG1	5324	broad.mit.edu	37	chr8	57079984	57079984	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgtgtatggaggtgattcttCagatgatctttccggtgaaa	12	5	3	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:57079984C>T	uc003xsq.3	-	3	772	c.321G>A	c.(319-321)CTG>CTA	p.L107L	PLAG1_uc003xsr.3_Silent_p.L107L|PLAG1_uc010lyi.2_Silent_p.L107L|PLAG1_uc010lyj.2_Silent_p.L25L	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	107	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.|C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GGTGATTCTTCAGATGATCTT	0.393			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								0	0	0	0.009096	0	4	28										T	57079984	C	T	57079984	2	4	129	1	0	0	0	0	0	0	0	1	12018	813	29	1		1	PLAG1	8	57079984	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	15056936	57079984	89284038	118	38490										
CPA6	57094	broad.mit.edu	37	chr8	68334769	68334769	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttctttagcaggtgcattgtGatatttttcacagccagcat	8	8	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:68334769G>T	uc003xxq.3	-	11	1540	c.1284C>A	c.(1282-1284)ATC>ATA	p.I428I	CPA6_uc003xxr.3_Silent_p.I184I	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	428					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			GGTGCATTGTGATATTTTTCA	0.453													1	0	4.3838e-07	0.001855	4.66237e-07	12	173										T	68334769	G	T	68334769	2	4	129	1	0	0	0	0	0	0	0	1	3794	1280	45	3		3	CPA6	8	68334769	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	11254785	68334769	78029253	119	38491										
VPS13B	157680	broad.mit.edu	37	chr8	100796630	100796630	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cactgcggtttggccaggtgGatactgatgaaaatattctg	12	7	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:100796630G>A	uc003yiv.2	+	43	8053	c.7942G>A	c.(7942-7944)GAT>AAT	p.D2648N	VPS13B_uc003yiw.2_Missense_Mutation_p.D2623N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2648					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGGCCAGGTGGATACTGATGA	0.468													0	0	0	0.012319	0	22	179										A	100796630	G	A	100796630	3	1	129	1	0	0	0	0	1	0	0	0	17187	1174	41	1	8302	1	VPS13B	8	100796630	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	32461861	100796630	45567392	120	38492										
YWHAZ	7534	broad.mit.edu	37	chr8	101932934	101932934	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aggccggttaattttcccctCcttctcctgcttcagcttcg	7	15	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:101932934C>G	uc011lhe.1	-	6	902	c.725G>C	c.(724-726)GGA>GCA	p.G242A	YWHAZ_uc003yjv.2_Missense_Mutation_p.G242A|YWHAZ_uc011lhf.1_Missense_Mutation_p.G242A|YWHAZ_uc003yjw.2_Missense_Mutation_p.G242A|YWHAZ_uc010mbq.2_Missense_Mutation_p.G165A|YWHAZ_uc011lhg.1_Missense_Mutation_p.G122A|YWHAZ_uc010mbr.2_Missense_Mutation_p.G242A|YWHAZ_uc003yjx.2_Missense_Mutation_p.G242A	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	242					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	ATTTTCCCCTCCTTCTCCTGC	0.453													0	0	0	0.001984	0	6	88										G	101932934	C	G	101932934	3	3	129	1	0	0	0	0	1	0	0	0	17503	855	30	1	16	1	YWHAZ	8	101932934	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1136304	101932934	44431088	121	38493										
CSMD3	114788	broad.mit.edu	37	chr8	113299395	113299395	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atcacaagcataacgtacagTacttttagttctgaaattgc	6	8	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:113299395T>A	uc003ynu.2	-	58	9388	c.9229A>T	c.(9229-9231)ACT>TCT	p.T3077S	CSMD3_uc003yns.2_Missense_Mutation_p.T2279S|CSMD3_uc003ynt.2_Missense_Mutation_p.T3037S|CSMD3_uc011lhx.1_Missense_Mutation_p.T2908S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3077	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAACGTACAGTACTTTTAGTT	0.473										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004482	0	9	130										A	113299395	T	A	113299395	3	1	129	1	0	0	0	0	1	0	0	0	3946	1638	57	5	1950	5	CSMD3	8	113299395	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	11366461	113299395	33064627	122	38494										
DENND3	22898	broad.mit.edu	37	chr8	142161801	142161801	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acgctggtcactgagtgcttCatggcctacctgtatccgct	10	13	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:142161801C>T	uc003yvy.2	+	7	977	c.699C>T	c.(697-699)TTC>TTT	p.F233F	DENND3_uc010mep.2_Silent_p.F246F	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	233	DENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGAGTGCTTCATGGCCTACC	0.602													0	0	0	0.013726	0	36	168										T	142161801	C	T	142161801	2	4	129	1	0	0	0	0	0	0	0	1	4432	825	29	1		1	DENND3	8	142161801	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	28862406	142161801	4202221	123	38495										
KIFC2	90990	broad.mit.edu	37	chr8	145693121	145693121	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aggagctgaagcagcagctgGaacagcaggaggaggagttg	18	6	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr8:145693121G>C	uc003zcz.2	+	6	705	c.640G>C	c.(640-642)GAA>CAA	p.E214Q	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	214	Potential.|Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GCAGCAGCTGGAACAGCAGGA	0.647											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	15	97										C	145693121	G	C	145693121	3	2	129	1	0	0	0	0	1	0	0	0	8313	1175	41	1	662	1	KIFC2	8	145693121	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3531320	145693121	670901	124	38496										
PLIN2	123	broad.mit.edu	37	chr9	19119735	19119735	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgagagcctgctggtaggcAcgggagtgaagcttggtaga	17	7	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19119735A>T	uc003zno.2	-	6	869	c.690T>A	c.(688-690)CGT>CGA	p.R230R	PLIN2_uc011lna.1_Silent_p.R202R|PLIN2_uc011lnb.1_Missense_Mutation_p.V187E	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	230					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GCTGGTAGGCACGGGAGTGAA	0.433													0	0	0	0.008291	0	10	140										T	19119735	A	T	19119735	2	4	129	1	0	0	0	0	0	0	0	1	12090	146	6	5		5	PLIN2	9	19119735	Silent	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08		19119735	122093696	125	38497			1	177		3	3	1353	N	G_C_A	6.1511e-05
PLIN2	123	broad.mit.edu	37	chr9	19119764	19119764	+	Nonsense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aagcttggtagacagggatcCcagtctaacataataacttg	9	8	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19119764C>A	uc003zno.2	-	6	840	c.661G>T	c.(661-663)GGA>TGA	p.G221*	PLIN2_uc011lna.1_Nonsense_Mutation_p.G193*|PLIN2_uc011lnb.1_Missense_Mutation_p.W177C	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	221					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GACAGGGATCCCAGTCTAACA	0.413													1	0	7.48243e-07	0.006214	7.93137e-07	8	140										A	19119764	C	A	19119764	4	1	129	1	0	0	0	0	0	1	0	0	12090	632	22	4	664	4	PLIN2	9	19119764	Nonsense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	29	19119764	122093667	126	38498			1	177		3	3	1353	N	G_C_A	6.1511e-05
PLIN2	123	broad.mit.edu	37	chr9	19121087	19121087	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgtgatcgtgctggccacaGaatccttggccccagtcaca	10	14	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:19121087G>A	uc003zno.2	-	5	565	c.386C>T	c.(385-387)TCT>TTT	p.S129F	PLIN2_uc011lna.1_Missense_Mutation_p.S101F|PLIN2_uc011lnb.1_Missense_Mutation_p.S129F	NM_001122	NP_001113	Q99541	PLIN2_HUMAN	adipose differentiation-related protein	129					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				ovary(2)	2						GCTGGCCACAGAATCCTTGGC	0.532													0	0	0	0.001984	0	7	72										A	19121087	G	A	19121087	3	1	129	1	0	0	0	0	1	0	0	0	12090	942	33	1	943	1	PLIN2	9	19121087	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1323	19121087	122092344	127	38499			1	177		3	3	1353	N	G_C_A	6.1511e-05
KIAA1161	57462	broad.mit.edu	37	chr9	34372105	34372105	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cccacgcacactcggtagctCagctctggcgctgcggcgcg	13	17	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:34372105C>T	uc003zue.3	-	3	1004	c.837G>A	c.(835-837)CTG>CTA	p.L279L		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	279	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		CTCGGTAGCTCAGCTCTGGCG	0.667													0	0	0	0.000602	0	4	57										T	34372105	C	T	34372105	2	4	129	1	0	0	0	0	0	0	0	1	8211	813	29	1		1	KIAA1161	9	34372105	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	15251018	34372105	106841326	128	38500										
KIAA1161	57462	broad.mit.edu	37	chr9	34372876	34372876	+	Silent	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcctcggggttctgacgctaTgcgtagcagccaggccggcg	16	13	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:34372876T>C	uc003zue.3	-	2	233	c.66A>G	c.(64-66)GCA>GCG	p.A22A		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	22	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		TCTGACGCTATGCGTAGCAGC	0.637													0	0	0	0.008291	0	11	224										C	34372876	T	C	34372876	2	2	129	1	0	0	0	0	0	0	0	1	8211	1451	51	5		5	KIAA1161	9	34372876	Silent	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	771	34372876	106840555	129	38501										
TRPM3	80036	broad.mit.edu	37	chr9	73167853	73167853	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggtcatgtggctgaagatgaTcagtggtgggggcagaactg	18	5	2	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:73167853T>C	uc004aid.2	-	23	3689	c.3445A>G	c.(3445-3447)ATC>GTC	p.I1149V	TRPM3_uc004ahu.2_Missense_Mutation_p.I991V|TRPM3_uc004ahv.2_Missense_Mutation_p.I951V|TRPM3_uc004ahw.2_Missense_Mutation_p.I1021V|TRPM3_uc004ahx.2_Missense_Mutation_p.I1008V|TRPM3_uc004ahy.2_Missense_Mutation_p.I1011V|TRPM3_uc004ahz.2_Missense_Mutation_p.I998V|TRPM3_uc004aia.2_Missense_Mutation_p.I996V|TRPM3_uc004aib.2_Missense_Mutation_p.I986V|TRPM3_uc004aic.2_Missense_Mutation_p.I1149V	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1174	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CTGAAGATGATCAGTGGTGGG	0.483													0	0	0	0.010504	0	22	202										C	73167853	T	C	73167853	3	2	129	1	0	0	0	0	1	0	0	0	16584	1435	50	5	1690	5	TRPM3	9	73167853	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	38794977	73167853	68045578	130	38502										
FRMD3	257019	broad.mit.edu	37	chr9	85913693	85913693	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	caggaggctccctctggatcTtggaactggcctccaccacc	10	16	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:85913693T>A	uc004ams.1	-	12	1242	c.1040A>T	c.(1039-1041)AAG>ATG	p.K347M	FRMD3_uc004amr.1_Missense_Mutation_p.K333M	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	347						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						CCTCTGGATCTTGGAACTGGC	0.498													0	0	0	0.001984	0	7	61										A	85913693	T	A	85913693	3	1	129	1	0	0	0	0	1	0	0	0	6050	1609	56	5	765	5	FRMD3	9	85913693	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	12745840	85913693	55299738	131	38503										
DAPK1	1612	broad.mit.edu	37	chr9	90262280	90262280	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acgtcgataccttgaaatttCtcagtgagaacaaatgccct	7	10	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:90262280C>G	uc004apc.2	+	14	1429	c.1291C>G	c.(1291-1293)CTC>GTC	p.L431V	DAPK1_uc004ape.2_Missense_Mutation_p.L431V|DAPK1_uc004apd.2_Missense_Mutation_p.L431V|DAPK1_uc011ltg.1_Missense_Mutation_p.L431V|DAPK1_uc011lth.1_Missense_Mutation_p.L168V|DAPK1_uc004apf.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	431	ANK 2.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CTTGAAATTTCTCAGTGAGAA	0.502									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				0	0	0	0.001855	0	13	69										G	90262280	C	G	90262280	3	3	129	1	0	0	0	0	1	0	0	0	4235	913	32	1	1341	1	DAPK1	9	90262280	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4348587	90262280	50951151	132	38504										
ALAD	210	broad.mit.edu	37	chr9	116152053	116152053	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccctgcccacccctgctcacCggaaagggccatagaaacag	9	17	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:116152053C>T	uc011lxf.1	-	8	828	c.626G>A	c.(625-627)CGG>CAG	p.R209Q	ALAD_uc011lxe.1_Missense_Mutation_p.R192Q|ALAD_uc004bhl.3_Missense_Mutation_p.R238Q	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	209		Substrate 1.			heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	CCCTGCTCACCGGAAAGGGCC	0.562													0	0	0	0.001168	0	6	41										T	116152053	C	T	116152053	3	4	129	1	0	0	0	0	1	0	0	0	483	666	23	2	386	2	ALAD	9	116152053	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	25889773	116152053	25061378	133	38505										
ADAMTS13	11093	broad.mit.edu	37	chr9	136324257	136324257	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	accctccaatcatgggtaccGgagatgcaggaccctcagtc	10	14	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:136324257G>A	uc004cdv.3	+	29	4683	c.4239G>A	c.(4237-4239)CCG>CCA	p.P1413P	ADAMTS13_uc004cdp.3_3'UTR|ADAMTS13_uc004cdt.1_Silent_p.P1357P|ADAMTS13_uc004cdu.1_Silent_p.P1326P|ADAMTS13_uc004cdw.3_Silent_p.P1357P|ADAMTS13_uc004cdx.3_Silent_p.P1326P|ADAMTS13_uc004cdz.3_Silent_p.P1083P|ADAMTS13_uc004ceb.3_Silent_p.P209P|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1413	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CATGGGTACCGGAGATGCAGG	0.597													0	0	0	0.004672	0	3	27										A	136324257	G	A	136324257	2	1	129	1	0	0	0	0	0	0	0	1	258	1103	39	2		2	ADAMTS13	9	136324257	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	20172204	136324257	4889174	134	38506										
RXRA	6256	broad.mit.edu	37	chr9	137328331	137328331	+	Silent	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aggttcgctaagctcttgctCcgcctgccggctctgcgctc	11	16	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:137328331C>G	uc004cfb.2	+	10	1422	c.1260C>G	c.(1258-1260)CTC>CTG	p.L420L	RXRA_uc004cfc.1_Silent_p.L323L	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	420	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	AGCTCTTGCTCCGCCTGCCGG	0.612													0	0	0	0.004482	0	9	144										G	137328331	C	G	137328331	2	3	129	1	0	0	0	0	0	0	0	1	13763	842	30	1		1	RXRA	9	137328331	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1004074	137328331	3885100	135	38507										
ANAPC2	29882	broad.mit.edu	37	chr9	140074639	140074639	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tggcatggaggtaccttgagCtgctcatacttcttgcagta	11	9	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:140074639C>G	uc004clr.1	-	10	1957	c.1884G>C	c.(1882-1884)CAG>CAC	p.Q628H	ANAPC2_uc004clq.1_Missense_Mutation_p.Q484H	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	628					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GTACCTTGAGCTGCTCATACT	0.632													0	0	0	0.000602	0	5	38										G	140074639	C	G	140074639	3	3	129	1	0	0	0	0	1	0	0	0	603	796	28	4	600	4	ANAPC2	9	140074639	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2746308	140074639	1138792	136	38508										
ANAPC2	29882	broad.mit.edu	37	chr9	140076196	140076196	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcctgagtcatcctcactgtCctggcctgtctccaggctcg	10	16	3	1	rs142080330		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr9:140076196C>T	uc004clr.1	-	7	1478	c.1405G>A	c.(1405-1407)GAC>AAC	p.D469N	ANAPC2_uc004clq.1_Missense_Mutation_p.D325N	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	469					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		TCCTCACTGTCCTGGCCTGTC	0.652													0	0	0	0.000602	0	5	45										T	140076196	C	T	140076196	3	4	129	1	0	0	0	0	1	0	0	0	603	855	30	1	1091	1	ANAPC2	9	140076196	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1557	140076196	1137235	137	38509										
ITIH2	3698	broad.mit.edu	37	chr10	7768927	7768927	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aaatagactgtggaagcaatGaagaccatattggatgacct	10	6	0	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:7768927G>A	uc001ijs.2	+	10	1161	c.999G>A	c.(997-999)ATG>ATA	p.M333I		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	333	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TGGAAGCAATGAAGACCATAT	0.393													0	0	0	0.000602	0	5	70										A	7768927	G	A	7768927	3	1	129	1	0	0	0	0	1	0	0	0	7904	1290	45	1	1037	1	ITIH2	10	7768927	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08		7768927	127765820	138	38510										
FRMD4A	55691	broad.mit.edu	37	chr10	13712435	13712435	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggcaggattttctgttcatCcagtttgaaggctgttccta	11	8	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:13712435C>T	uc001ims.2	-	17	1697	c.1345G>A	c.(1345-1347)GAT>AAT	p.D449N	FRMD4A_uc009xjf.1_Missense_Mutation_p.D449N|FRMD4A_uc001imt.1_Missense_Mutation_p.D482N	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	449						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						TTCTGTTCATCCAGTTTGAAG	0.498													0	0	0	0.00245	0	15	95										T	13712435	C	T	13712435	3	4	129	1	0	0	0	0	1	0	0	0	6051	855	30	1	1806	1	FRMD4A	10	13712435	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	5943508	13712435	121822312	139	38511										
FRMD4A	55691	broad.mit.edu	37	chr10	13712504	13712504	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccctggatccaggggatattCtactggcagcttgcccgtga	12	12	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:13712504C>T	uc001ims.2	-	17	1628	c.1276G>A	c.(1276-1278)GAA>AAA	p.E426K	FRMD4A_uc009xjf.1_Missense_Mutation_p.E426K|FRMD4A_uc001imt.1_Missense_Mutation_p.E459K	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	426						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						AGGGGATATTCTACTGGCAGC	0.483													0	0	0	0.004007	0	15	110										T	13712504	C	T	13712504	3	4	129	1	0	0	0	0	1	0	0	0	6051	922	32	1	1875	1	FRMD4A	10	13712504	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	69	13712504	121822243	140	38512										
ZNF438	220929	broad.mit.edu	37	chr10	31133898	31133898	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgccttggggtctcatttctCagcttcactggaaagttcga	10	10	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:31133898C>T	uc010qdz.1	-	8	2914	c.2479G>A	c.(2479-2481)GAG>AAG	p.E827K	ZNF438_uc001ivn.2_Missense_Mutation_p.E778K|ZNF438_uc010qdy.1_Missense_Mutation_p.E817K|ZNF438_uc001ivo.3_Missense_Mutation_p.E391K|ZNF438_uc009xlg.2_Missense_Mutation_p.E827K|ZNF438_uc001ivp.3_Missense_Mutation_p.E817K|ZNF438_uc010qea.1_Missense_Mutation_p.E827K|ZNF438_uc010qeb.1_Missense_Mutation_p.E827K	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	827					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				TCTCATTTCTCAGCTTCACTG	0.512													0	0	0	0.008361	0	29	298										T	31133898	C	T	31133898	3	4	129	1	0	0	0	0	1	0	0	0	17907	835	29	1	11	1	ZNF438	10	31133898	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	17421394	31133898	104400849	141	38513										
PARD3	56288	broad.mit.edu	37	chr10	34420399	34420399	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccaattacttacccagggttGctcaaaactataggtccgcc	7	13	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:34420399G>C	uc010qej.1	-	23	3541	c.3541C>G	c.(3541-3543)CAA>GAA	p.Q1181E	PARD3_uc010qek.1_Missense_Mutation_p.Q1178E|PARD3_uc010qel.1_Missense_Mutation_p.Q1144E|PARD3_uc010qem.1_Missense_Mutation_p.Q1165E|PARD3_uc010qen.1_Missense_Mutation_p.Q1135E|PARD3_uc010qeo.1_Missense_Mutation_p.Q1098E|PARD3_uc010qep.1_Missense_Mutation_p.Q1091E|PARD3_uc010qeq.1_Missense_Mutation_p.Q1069E	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	1181					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				ACCCAGGGTTGCTCAAAACTA	0.463													0	0	0	0.003163	0	15	57										C	34420399	G	C	34420399	3	2	129	1	0	0	0	0	1	0	0	0	11443	1328	46	4	541	4	PARD3	10	34420399	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3286501	34420399	101114348	142	38514										
ZNF37A	7587	broad.mit.edu	37	chr10	38406754	38406754	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cagagtgtttacccattcagCcagaagttaaatctcactcc	6	12	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:38406754C>G	uc001izk.2	+	8	1494	c.675C>G	c.(673-675)AGC>AGG	p.S225R	ZNF37A_uc001izl.2_Missense_Mutation_p.S225R|ZNF37A_uc001izm.2_Missense_Mutation_p.S225R	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	225						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						ACCCATTCAGCCAGAAGTTAA	0.348													0	0	0	0.001168	0	6	55										G	38406754	C	G	38406754	3	3	129	1	0	0	0	0	1	0	0	0	17869	738	26	4	689	4	ZNF37A	10	38406754	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	3986355	38406754	97127993	143	38515										
EIF5AL1	143244	broad.mit.edu	37	chr10	81272751	81272751	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cagaggaccttcgtctccctGagggagaccttggcaaggag	14	11	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:81272751G>A	uc009xrx.2	+	1	395	c.346G>A	c.(346-348)GAG>AAG	p.E116K	uc010qls.1_5'Flank	NM_001099692	NP_001093162	Q6IS14	IF5AL_HUMAN	eukaryotic translation initiation factor 5A-like	116					mRNA transport|peptidyl-lysine modification to hypusine|positive regulation of translational elongation|positive regulation of translational termination|protein transport|translational frameshifting|transmembrane transport	endoplasmic reticulum membrane|nuclear pore	ribosome binding|translation elongation factor activity				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCGTCTCCCTGAGGGAGACCT	0.537													0	0	0	0.00308	0	6	154										A	81272751	G	A	81272751	3	1	129	1	0	0	0	0	1	0	0	0	5043	1291	45	1	348	1	EIF5AL1	10	81272751	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	42865997	81272751	54261996	144	38516										
TSPAN14	81619	broad.mit.edu	37	chr10	82269071	82269071	+	Silent	SNP	C	C	A	0	1	0	0	1	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgcagttctgtggcaccatCgtgctcatcttcttcctgga	9	13	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:82269071C>A	uc001kcj.3	+	5	401	c.294C>A	c.(292-294)ATC>ATA	p.I98I	TSPAN14_uc009xss.2_Intron|TSPAN14_uc001kci.3_Silent_p.I81I	NM_030927	NP_112189	Q8NG11	TSN14_HUMAN	tetraspanin 14 isoform 1	98	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2			Colorectal(32;0.229)			GTGGCACCATCGTGCTCATCT	0.617													1	0	0.00198382	0.001984	0.00202847	7	42										A	82269071	C	A	82269071	2	1	129	1	0	0	0	0	0	0	0	1	16635	874	31	3		3	TSPAN14	10	82269071	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	996320	82269071	53265676	145	38517										
CHST15	51363	broad.mit.edu	37	chr10	125798151	125798151	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgtcgtagaagaacgtccagGcattattatcccacatcgtg	9	10	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr10:125798151G>T	uc001lhl.2	-	4	1583	c.1070C>A	c.(1069-1071)GCC>GAC	p.A357D	CHST15_uc001lhm.2_Missense_Mutation_p.A357D|CHST15_uc001lhn.2_Missense_Mutation_p.A357D|CHST15_uc010que.1_Missense_Mutation_p.A357D|CHST15_uc001lho.2_Missense_Mutation_p.A357D	NM_015892	NP_056976	Q7LFX5	CHSTF_HUMAN	B cell RAG associated protein	357	Lumenal (Potential).				hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			ovary(1)	1						GAACGTCCAGGCATTATTATC	0.547													1	0	3.86212e-05	0.008291	4.01358e-05	10	52										T	125798151	G	T	125798151	3	4	129	1	0	0	0	0	1	0	0	0	3403	1203	42	4	631	4	CHST15	10	125798151	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	43529080	125798151	9736596	146	38518										
MUC5B	727897	broad.mit.edu	37	chr11	1264405	1264405	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cctcctccatcccggggaccAcccacaccgccacagtgctg	8	21	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:1264405A>C	uc009ycr.1	+	47	8500	c.8374A>C	c.(8374-8376)ACC>CCC	p.T2792P	MUC5B_uc001ltb.2_Missense_Mutation_p.T2102P	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2099	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCGGGGACCACCCACACCGC	0.602													0	0	0	0.007413	0	7	20										C	1264405	A	C	1264405	3	2	129	1	0	0	0	0	1	0	0	0	9979	159	6	5	6426	5	MUC5B	11	1264405	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08		1264405	133742111	147	38519										
ST5	6764	broad.mit.edu	37	chr11	8724142	8724142	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agcttatctgccacaaaaatGacccggcgctccagcagcag	9	14	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:8724142G>C	uc001mgt.2	-	14	2883	c.2697C>G	c.(2695-2697)GTC>GTG	p.V899V	ST5_uc009yfr.2_Silent_p.V479V|ST5_uc001mgu.2_Silent_p.V479V|ST5_uc001mgv.2_Silent_p.V899V|ST5_uc010rbp.1_Silent_p.V412V|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	899	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CCACAAAAATGACCCGGCGCT	0.572													0	0	0	0.001168	0	6	89										C	8724142	G	C	8724142	2	2	129	1	0	0	0	0	0	0	0	1	15219	1277	45	1		1	ST5	11	8724142	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	7459737	8724142	126282374	148	38520										
CHRM4	1132	broad.mit.edu	37	chr11	46407836	46407836	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agtagcccttgatgatgtacAcggtgtagaggttcatggag	14	6	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:46407836A>G	uc001nct.1	-	1	272	c.272T>C	c.(271-273)GTG>GCG	p.V91A		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	91	Extracellular (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GATGATGTACACGGTGTAGAG	0.577													0	0	0	0.006214	0	10	62										G	46407836	A	G	46407836	3	3	129	1	0	0	0	0	1	0	0	0	3379	159	6	5	1171	5	CHRM4	11	46407836	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	37683694	46407836	88598680	149	38521										
CABP4	57010	broad.mit.edu	37	chr11	67223087	67223087	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctggggagcagacaggccccGaggccccggggagcagcaat	17	13	0	1	rs149056460		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:67223087G>A	uc001olo.2	+	1	270	c.193G>A	c.(193-195)GAG>AAG	p.E65K	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	65					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GACAGGCCCCGAGGCCCCGGG	0.701													0	0	0	0.004672	0	3	24										A	67223087	G	A	67223087	3	1	129	1	0	0	0	0	1	0	0	0	2533	1059	37	1	195	1	CABP4	11	67223087	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	20815251	67223087	67783429	150	38522										
KRTAP5-10	387273	broad.mit.edu	37	chr11	71276978	71276978	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggctccaaggggggctgtggCtcctgtgggggctccaaagg	19	10	0	0	rs77786965		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:71276978C>T	uc001oqt.1	+	1	370	c.345C>T	c.(343-345)GGC>GGT	p.G115G		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	115	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GGGGCTGTGGCTCCTGTGGGG	0.652													0	0	0	0.006214	0	6	240										T	71276978	C	T	71276978	2	4	129	1	0	0	0	0	0	0	0	1	8559	784	28	2		2	KRTAP5-10	11	71276978	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4053891	71276978	63729538	151	38523										
MTNR1B	4544	broad.mit.edu	37	chr11	92703069	92703069	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tggacgtcgtgggcaacctcCtggtgatcctctccgtgctc	12	14	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:92703069C>T	uc001pdk.1	+	1	281	c.178C>T	c.(178-180)CTG>TTG	p.L60L		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	60	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GGGCAACCTCCTGGTGATCCT	0.667													0	0	0	0.001168	0	5	13										T	92703069	C	T	92703069	2	4	129	1	0	0	0	0	0	0	0	1	9952	680	24	2		2	MTNR1B	11	92703069	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	21426091	92703069	42303447	152	38524										
MAML2	84441	broad.mit.edu	37	chr11	95724768	95724768	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agagtctgcttctttcccatCaattgctgattcaacagtga	7	10	4	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:95724768C>G	uc001pfw.1	-	3	3544	c.2259G>C	c.(2257-2259)TTG>TTC	p.L753F		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	753					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				TCTTTCCCATCAATTGCTGAT	0.488			T	MECT1|CRTC3	salivary gland mucoepidermoid								0	0	0	0.006122	0	19	109										G	95724768	C	G	95724768	3	3	129	1	0	0	0	0	1	0	0	0	9206	825	29	1	1223	1	MAML2	11	95724768	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	3021699	95724768	39281748	153	38525										
ATM	472	broad.mit.edu	37	chr11	108218071	108218071	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgataaatgagcagtcagcaGaacttgtacatatagatcta	8	6	2	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:108218071G>C	uc001pkb.1	+	59	9035	c.8650G>C	c.(8650-8652)GAA>CAA	p.E2884Q	ATM_uc009yxr.1_Missense_Mutation_p.E2884Q|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E1536Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2884	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCAGTCAGCAGAACTTGTACA	0.313			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.008291	0	11	26										C	108218071	G	C	108218071	3	2	129	1	0	0	0	0	1	0	0	0	1109	943	33	1	8880	1	ATM	11	108218071	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	12493303	108218071	26788445	154	38526										
BUD13	84811	broad.mit.edu	37	chr11	116633771	116633772	+	Missense_Mutation	DNP	CC	CC	AT													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaggagtcatgacggatcctCctgggaggagatgtgtctga							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:116633771_116633772CC>AT	uc001ppn.2	-	4	567_568	c.533_534GG>AT	c.(532-534)AGG>AAT	p.R178N	BUD13_uc001ppo.2_Missense_Mutation_p.R178N|BUD13_uc009yzc.2_Missense_Mutation_p.R178N	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	178	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GACGGATCCTCCTGGGAGGAGA	0.584													0	0	0	0.004672	0	33	215										AT	116633772	CC	AT	116633771	3	1	129	1	0	0	0	0	1	0	0	0	1573	854	30	3	1353	3	BUD13	11	116633771	Missense_Mutation	DNP	CC	TCGA-K4-A3WU-01B-11D-A23M-08	8415700	116633771	18372745	155	38527										
CXCR5	643	broad.mit.edu	37	chr11	118754653	118754653	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctcacagccggcacagccatGaactacccgctaacgctgga	9	16	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:118754653G>T	uc001pue.3	+	1	113	c.3G>T	c.(1-3)ATG>ATT	p.M1I		NM_001716	NP_001707	P32302	CXCR5_HUMAN	Burkitt lymphoma receptor 1 isoform 1	1	Extracellular (Potential).				B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCACAGCCATGAACTACCCGC	0.577													1	0	0.00909568	0.009096	0.00918231	4	16										T	118754653	G	T	118754653	3	4	129	1	0	0	0	0	1	0	0	0	4094	1290	45	3	5	3	CXCR5	11	118754653	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2120882	118754653	16251863	156	38528										
CDON	50937	broad.mit.edu	37	chr11	125850958	125850958	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcttacattcactagatgatGaggatgttcaaaatccacgt	7	8	3	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:125850958G>A	uc009zbw.2	-	17	3390	c.3262C>T	c.(3262-3264)CAT>TAT	p.H1088Y	CDON_uc001qdb.3_Missense_Mutation_p.H465Y|CDON_uc001qdc.3_Missense_Mutation_p.H1088Y	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	1088	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		ACTAGATGATGAGGATGTTCA	0.463													0	0	0	0.009535	0	33	85										A	125850958	G	A	125850958	3	1	129	1	0	0	0	0	1	0	0	0	3170	1290	45	1	548	1	CDON	11	125850958	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	7096305	125850958	9155558	157	38529										
CDON	50937	broad.mit.edu	37	chr11	125889616	125889616	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaaaccagcacttttttcttCtgctgtaataacatgctttg	6	9	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:125889616C>G	uc009zbw.2	-	4	522	c.394G>C	c.(394-396)GAA>CAA	p.E132Q	CDON_uc001qdc.3_Missense_Mutation_p.E132Q|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.E132Q	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	132	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTTTTTTCTTCTGCTGTAATA	0.393													0	0	0	0.00278	0	25	132										G	125889616	C	G	125889616	3	3	129	1	0	0	0	0	1	0	0	0	3170	922	32	1	3468	1	CDON	11	125889616	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	38658	125889616	9116900	158	38530										
APLP2	334	broad.mit.edu	37	chr11	130011399	130011399	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	catgactgtttcaggtcattGacgagactctggatgttaag	11	7	3	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr11:130011399G>T	uc010sby.1	+	16	2123	c.1966G>T	c.(1966-1968)GAC>TAC	p.D656Y	APLP2_uc001qfp.2_Missense_Mutation_p.D644Y|APLP2_uc001qfq.2_Missense_Mutation_p.D588Y|APLP2_uc010sbz.1_Missense_Mutation_p.D444Y|APLP2_uc001qfr.2_Missense_Mutation_p.D410Y|APLP2_uc001qfs.2_Missense_Mutation_p.D415Y|APLP2_uc001qfv.2_Missense_Mutation_p.D547Y|APLP2_uc009zcv.2_Missense_Mutation_p.D4Y	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	656	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TCAGGTCATTGACGAGACTCT	0.498													1	0	1.02788e-11	0.00499	1.12325e-11	17	43										T	130011399	G	T	130011399	3	4	129	1	0	0	0	0	1	0	0	0	779	1290	45	3	2028	3	APLP2	11	130011399	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	4121783	130011399	4995117	159	38531										
PRMT8	56341	broad.mit.edu	37	chr12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctcaggtgaacagcccccccTcccagcccccccagcccgtc	7	24	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:3649787T>C	uc001qmf.2	+	2	458	c.91T>C	c.(91-93)TCC>CCC	p.S31P	PRMT8_uc009zed.2_Missense_Mutation_p.S22P|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	31	SH3-binding 1.				regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652													0	0	0	0.00623	0	22	90										C	3649787	T	C	3649787	3	2	129	1	0	0	0	0	1	0	0	0	12542	1551	54	5	97	5	PRMT8	12	3649787	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08		3649787	130202108	160	38532										
CLSTN3	9746	broad.mit.edu	37	chr12	7295617	7295617	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcgagagcctgggcaaaggcAtgaaggtattgccccatcct	12	11	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:7295617A>T	uc001qsr.2	+	11	1971	c.1693A>T	c.(1693-1695)ATG>TTG	p.M565L	CLSTN3_uc001qss.2_Missense_Mutation_p.M577L	NM_014718	NP_055533	Q9BQT9	CSTN3_HUMAN	calsyntenin 3 precursor	565	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			large_intestine(1)	1						GGGCAAAGGCATGAAGGTATT	0.622													0	0	0	0.00308	0	8	47										T	7295617	A	T	7295617	3	4	129	1	0	0	0	0	1	0	0	0	3563	217	8	5	1735	5	CLSTN3	12	7295617	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	3645830	7295617	126556278	161	38533										
SLC2A3	6515	broad.mit.edu	37	chr12	8086418	8086418	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcactcaccttctcaggagcAttgatgaccccagtgttgta	9	12	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:8086418A>T	uc001qtr.2	-	2	358	c.96T>A	c.(94-96)AAT>AAA	p.N32K	SLC2A3_uc001qts.2_Missense_Mutation_p.N32K	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	32	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TCTCAGGAGCATTGATGACCC	0.428											OREG0021656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	6	73										T	8086418	A	T	8086418	3	4	129	1	0	0	0	0	1	0	0	0	14545	214	8	5	1430	5	SLC2A3	12	8086418	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	790801	8086418	125765477	162	38534										
CLEC9A	283420	broad.mit.edu	37	chr12	10205299	10205299	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccttagacatgcacgaggaaGaaatatacacctctcttcag	7	11	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:10205299G>C	uc001qxa.2	+	4	626	c.13G>C	c.(13-15)GAA>CAA	p.E5Q		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	5	Cytoplasmic (Potential).|ITAM-like.				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						GCACGAGGAAGAAATATACAC	0.448													0	0	0	0.010729	0	11	61										C	10205299	G	C	10205299	3	2	129	1	0	0	0	0	1	0	0	0	3522	943	33	1	15	1	CLEC9A	12	10205299	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2118881	10205299	123646596	163	38535										
TAS2R31	259290	broad.mit.edu	37	chr12	11183288	11183288	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccttggtgctgggatcttgaGatcctttaccatggagctgc	12	10	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:11183288G>C	uc001qzo.1	-	1	719	c.647C>G	c.(646-648)TCT>TGT	p.S216C	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	216	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						GGGATCTTGAGATCCTTTACC	0.408													0	0	0	0.008871	0	21	283										C	11183288	G	C	11183288	3	2	129	1	0	0	0	0	1	0	0	0	15571	942	33	1	286	1	TAS2R31	12	11183288	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	977989	11183288	122668607	164	38536										
FAM60A	58516	broad.mit.edu	37	chr12	31446788	31446788	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgatctggttgctttttatCctgttcccagatagagtttt	8	8	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:31446788C>G	uc010sjz.1	-	4	545	c.306G>C	c.(304-306)AGG>AGC	p.R102S	FAM60A_uc001rkd.2_Missense_Mutation_p.R102S|FAM60A_uc010ska.1_Missense_Mutation_p.R102S|FAM60A_uc001rke.2_Missense_Mutation_p.R102S|FAM60A_uc010skb.1_Intron|FAM60A_uc001rkc.2_Missense_Mutation_p.R127S	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	102											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					TGCTTTTTATCCTGTTCCCAG	0.333													0	0	0	0.001984	0	7	35										G	31446788	C	G	31446788	3	3	129	1	0	0	0	0	1	0	0	0	5595	854	30	1	371	1	FAM60A	12	31446788	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	20263500	31446788	102405107	165	38537										
TMEM106C	79022	broad.mit.edu	37	chr12	48360997	48360997	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttgctgtttggtagcttcttCtgcacggtacctgagatcct	10	10	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:48360997C>T	uc001rqp.2	+	7	724	c.609C>T	c.(607-609)TTC>TTT	p.F203F	TMEM106C_uc001rqo.2_Silent_p.F184F|TMEM106C_uc001rqr.2_Silent_p.F203F|TMEM106C_uc001rqq.2_Silent_p.F184F	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	203	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		GTAGCTTCTTCTGCACGGTAC	0.488													0	0	0	0.013114	0	45	215										T	48360997	C	T	48360997	2	4	129	1	0	0	0	0	0	0	0	1	16019	912	32	1		1	TMEM106C	12	48360997	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	16914209	48360997	85490898	166	38538										
KRT6A	3853	broad.mit.edu	37	chr12	52886867	52886867	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cctggagcgggacacggagaCgctgctgaagccagagcggc	17	12	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:52886867C>T	uc001sam.2	-	1	315	c.106G>A	c.(106-108)GTC>ATC	p.V36I		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	36	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GACACGGAGACGCTGCTGAAG	0.667													0	0	0	0.001168	0	6	164										T	52886867	C	T	52886867	3	4	129	1	0	0	0	0	1	0	0	0	8480	536	19	2	1624	2	KRT6A	12	52886867	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4525870	52886867	80965028	167	38539										
OBFC2B	79035	broad.mit.edu	37	chr12	56622879	56622879	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tccccctcatactccctcccAcccacccagcacccgaatca	2	24	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:56622879A>C	uc001ski.2	+	7	642	c.518A>C	c.(517-519)CAC>CCC	p.H173P	OBFC2B_uc001skk.2_Missense_Mutation_p.H198P|OBFC2B_uc001skj.2_Missense_Mutation_p.H189P	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	173	Pro-rich.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						ACTCCCTCCCACCCACCCAGC	0.612								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.010729	0	5	22										C	56622879	A	C	56622879	3	2	129	1	0	0	0	0	1	0	0	0	10809	159	6	5	540	5	OBFC2B	12	56622879	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	3736012	56622879	77229016	168	38540										
STAT2	6773	broad.mit.edu	37	chr12	56745131	56745131	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggcgttgcgtaggtccacccCtttggtcagagggtcatcct	13	12	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:56745131C>T	uc001slc.2	-	9	964	c.886G>A	c.(886-888)GGG>AGG	p.G296R	STAT2_uc001slb.2_5'Flank|STAT2_uc001sld.2_Missense_Mutation_p.G292R|STAT2_uc010sqn.1_Missense_Mutation_p.G292R	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	296					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						AGGTCCACCCCTTTGGTCAGA	0.572													0	0	0	0.003954	0	27	306										T	56745131	C	T	56745131	3	4	129	1	0	0	0	0	1	0	0	0	15264	681	24	2	1733	2	STAT2	12	56745131	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	122252	56745131	77106764	169	38541										
LRP1	4035	broad.mit.edu	37	chr12	57588794	57588794	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctgctcagaggcccagtttGagtgccagaaccatcgctgc	11	13	2	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:57588794G>C	uc001snd.2	+	51	8684	c.8218G>C	c.(8218-8220)GAG>CAG	p.E2740Q		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2740	Extracellular (Potential).|LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGCCCAGTTTGAGTGCCAGAA	0.597													0	0	0	0.013537	0	13	154										C	57588794	G	C	57588794	3	2	129	1	0	0	0	0	1	0	0	0	8951	1291	45	1	8420	1	LRP1	12	57588794	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	843663	57588794	76263101	170	38542										
SRGAP1	57522	broad.mit.edu	37	chr12	64485155	64485155	+	Silent	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggggatttggaaacattcgtCaaggtactggcaccagccat	12	9	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:64485155C>G	uc010ssp.1	+	12	1592	c.1536C>G	c.(1534-1536)GTC>GTG	p.V512V	SRGAP1_uc001srv.2_Intron	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	512	Rho-GAP.				axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		AAACATTCGTCAAGGTACTGG	0.483													0	0	0	0.001984	0	6	46										G	64485155	C	G	64485155	2	3	129	1	0	0	0	0	0	0	0	1	15144	813	29	1		1	SRGAP1	12	64485155	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	6896361	64485155	69366740	171	38543										
PTPRB	5787	broad.mit.edu	37	chr12	71016176	71016176	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccccctccttttacctcttcAgtggtgctggagaagggctg	11	13	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:71016176A>G	uc001swc.3	-	3	746	c.702T>C	c.(700-702)ACT>ACC	p.T234T	PTPRB_uc001swa.3_Silent_p.T234T|PTPRB_uc001swd.3_Silent_p.T233T|PTPRB_uc009zrr.1_Silent_p.T113T|PTPRB_uc001swe.2_Silent_p.T234T	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:Variant_position_missing_in_P23467_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTACCTCTTCAGTGGTGCTGG	0.507													0	0	0	0.006214	0	8	218										G	71016176	A	G	71016176	2	3	129	1	0	0	0	0	0	0	0	1	12796	175	7	5		5	PTPRB	12	71016176	Silent	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	6531021	71016176	62835719	172	38544										
LRRIQ1	84125	broad.mit.edu	37	chr12	85531742	85531742	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atttagaggattttatatttGatgaagtaagtacgaactat	8	2	0	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:85531742G>C	uc001tac.2	+	19	4435	c.4324G>C	c.(4324-4326)GAT>CAT	p.D1442H		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1442										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTTTATATTTGATGAAGTAAG	0.284													0	0	0	0.006214	0	10	46										C	85531742	G	C	85531742	3	2	129	1	0	0	0	0	1	0	0	0	9029	1290	45	1	4398	1	LRRIQ1	12	85531742	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	14515566	85531742	48320153	173	38545										
NTS	4922	broad.mit.edu	37	chr12	86272159	86272159	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttccctcttggaagatgactCtgctaaatgtttgcagtctt	8	9	3	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:86272159C>G	uc001tag.2	+	3	279	c.172C>G	c.(172-174)CTG>GTG	p.L58V		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	58					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						GAAGATGACTCTGCTAAATGT	0.328													0	0	0	0.010729	0	11	133										G	86272159	C	G	86272159	3	3	129	1	0	0	0	0	1	0	0	0	10709	912	32	1	182	1	NTS	12	86272159	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	740417	86272159	47579736	174	38546										
MYL2	4633	broad.mit.edu	37	chr12	111348888	111348888	+	Missense_Mutation	SNP	T	T	C													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agcgagccccctcctagtccTtctcttctccgtgggtgatg							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:111348888T>C	uc001try.3	-	7	565	c.494A>G	c.(493-495)AAG>AGG	p.K165R	MYL2_uc001trx.3_Missense_Mutation_p.K146R	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	165	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						CTCCTAGTCCTTCTCTTCTCC	0.602													0	0	0	0.004007	0	16	119										C	111348888	T	C	111348888	3	2	129	1	0	0	0	0	1	0	0	0	10047	1609	56	5	10	5	MYL2	12	111348888	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	25076729	111348888	22503007	175	38547	201	2								
MYL2	4633	broad.mit.edu	37	chr12	111348892	111348892	+	Missense_Mutation	SNP	C	C	G													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agccccctcctagtccttctCttctccgtgggtgatgatgt							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:111348892C>G	uc001try.3	-	7	561	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	MYL2_uc001trx.3_Missense_Mutation_p.E145Q	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	164	EF-hand 3.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						TAGTCCTTCTCTTCTCCGTGG	0.607													0	0	0	0.004007	0	15	122										G	111348892	C	G	111348892	3	3	129	1	0	0	0	0	1	0	0	0	10047	922	32	1	14	1	MYL2	12	111348892	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4	111348892	22503003	176	38548	201	2								
GPR81	27198	broad.mit.edu	37	chr12	123214852	123214853	+	Frame_Shift_Ins	INS	-	-	C													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	catcacctgggagatggtgtINSccccctcgatgcggcagcac							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:123214852_123214853insC	uc001ucz.2	-	1	277_278	c.34_35insG	c.(34-36)GACfs	p.D12fs	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	12	Extracellular (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGAGATGGTGTCCCCCTCGATG	0.619																		8	53	---	---								C	123214853	-	C	123214852	7	5	129	1	0	1	1	0	0	0	0	0	6711	1667	58	0	1009	0	GPR81	12	123214852	Frame_Shift_Ins	INS	-	TCGA-K4-A3WU-01B-11D-A23M-08	11865960	123214852	10637043	177	38549										
PIWIL1	9271	broad.mit.edu	37	chr12	130846097	130846097	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	accatgacatgacagctgggCggaggtcaatcgcaggattt	13	9	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr12:130846097C>T	uc001uik.2	+	16	2011	c.1921C>T	c.(1921-1923)CGG>TGG	p.R641W	PIWIL1_uc001uij.1_Missense_Mutation_p.R641W	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	641	RNA-binding (By similarity).|Piwi.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GACAGCTGGGCGGAGGTCAAT	0.478													0	0	0	0.006122	0	17	130										T	130846097	C	T	130846097	3	4	129	1	0	0	0	0	1	0	0	0	11957	759	27	2	1979	2	PIWIL1	12	130846097	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	7631245	130846097	3005798	178	38550										
MYCBP2	23077	broad.mit.edu	37	chr13	77672741	77672741	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agcagtacttttttgaggtaGatttttatcatgtggtgagg	12	3	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:77672741G>C	uc001vkf.2	-	57	8525	c.8434C>G	c.(8434-8436)CTA>GTA	p.L2812V	MYCBP2_uc010aev.2_Missense_Mutation_p.L2216V|MYCBP2_uc001vkg.1_Missense_Mutation_p.L335V|MYCBP2_uc010aew.2_Missense_Mutation_p.L198V	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2812					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TTTTGAGGTAGATTTTTATCA	0.473													0	0	0	0.00308	0	8	116										C	77672741	G	C	77672741	3	2	129	1	0	0	0	0	1	0	0	0	10018	933	33	1	5600	1	MYCBP2	13	77672741	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08		77672741	37497137	179	38551										
MBNL2	10150	broad.mit.edu	37	chr13	97986694	97986694	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggaacaccacttcatccagtGgtgagtacatctttattcag	8	10	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:97986694G>T	uc010aft.2	+	3	1155	c.339G>T	c.(337-339)GTG>GTT	p.V113V	MBNL2_uc001vmz.2_Silent_p.V113V|MBNL2_uc001vna.2_Silent_p.V113V|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Silent_p.V113V	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	113					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			TTCATCCAGTGGTGAGTACAT	0.433													1	0	0.004672	0.004672	0.00473152	3	56										T	97986694	G	T	97986694	2	4	129	1	0	0	0	0	0	0	0	1	9354	1362	47	4		4	MBNL2	13	97986694	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	20313953	97986694	17183184	180	38552										
MYO16	23026	broad.mit.edu	37	chr13	109318494	109318494	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttatccaccacaatgacaaaGaaggtacatgataagaaaga	7	7	0	5			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr13:109318494G>C	uc001vqt.1	+	2	349	c.223G>C	c.(223-225)GAA>CAA	p.E75Q	MYO16_uc010agk.1_Missense_Mutation_p.E97Q	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	75	ANK 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CAATGACAAAGAAGGTACATG	0.418													0	0	0	0.004672	0	3	21										C	109318494	G	C	109318494	3	2	129	1	0	0	0	0	1	0	0	0	10064	943	33	1	225	1	MYO16	13	109318494	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	11331800	109318494	5851384	181	38553										
OR4L1	122742	broad.mit.edu	37	chr14	20528361	20528361	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggtcacagtgacatgtaggtCaacccttcattctcccttgt	8	12	4	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:20528361C>T	uc001vwn.1	+	1	158	c.158C>T	c.(157-159)TCA>TTA	p.S53L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ACATGTAGGTCAACCCTTCAT	0.423													0	0	0	0.006214	0	4	125										T	20528361	C	T	20528361	3	4	129	1	0	0	0	0	1	0	0	0	11074	838	29	1	160	1	OR4L1	14	20528361	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		20528361	86821179	182	38554										
ARHGAP5	394	broad.mit.edu	37	chr14	32560146	32560146	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atggagtagaatgcaaaattCatgtcattgaacaaacagag	9	5	2	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:32560146C>T	uc001wrl.2	+	2	510	c.271C>T	c.(271-273)CAT>TAT	p.H91Y	ARHGAP5_uc001wrm.2_Missense_Mutation_p.H91Y|ARHGAP5_uc001wrn.2_Missense_Mutation_p.H91Y|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	91					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		ATGCAAAATTCATGTCATTGA	0.373													0	0	0	0.001984	0	7	89										T	32560146	C	T	32560146	3	4	129	1	0	0	0	0	1	0	0	0	886	826	29	1	273	1	ARHGAP5	14	32560146	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	12031785	32560146	74789394	183	38555										
PAX9	5083	broad.mit.edu	37	chr14	37145475	37145475	+	Nonsense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctccttaccctaccccagccCaagtgtcgccttacatgacc	5	19	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:37145475C>T	uc001wty.3	+	5	1561	c.844C>T	c.(844-846)CAA>TAA	p.Q282*	PAX9_uc010amq.2_RNA	NM_006194	NP_006185	P55771	PAX9_HUMAN	paired box 9	282					multicellular organismal development|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.218)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.00998)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0181)		TACCCCAGCCCAAGTGTCGCC	0.532													0	0	0	0.013537	0	13	111										T	37145475	C	T	37145475	4	4	129	1	0	0	0	0	0	1	0	0	11486	595	21	2	858	2	PAX9	14	37145475	Nonsense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	4585329	37145475	70204065	184	38556										
DDHD1	80821	broad.mit.edu	37	chr14	53513571	53513571	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaaaaagggcaacatccaagGatgaccaataggcagtatgc	11	8	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:53513571G>A	uc001xai.2	-	13	2848	c.2618C>T	c.(2617-2619)TCC>TTC	p.S873F	DDHD1_uc001xaj.2_Missense_Mutation_p.S852F|DDHD1_uc001xah.2_Missense_Mutation_p.S845F|DDHD1_uc001xag.2_Missense_Mutation_p.S427F	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	873	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					AACATCCAAGGATGACCAATA	0.433													0	0	0	0.010729	0	11	65										A	53513571	G	A	53513571	3	1	129	1	0	0	0	0	1	0	0	0	4326	1174	41	1	88	1	DDHD1	14	53513571	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	16368096	53513571	53835969	185	38557										
DACT1	51339	broad.mit.edu	37	chr14	59113460	59113460	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agaatgtggggctgtaccccGcgcctgtgcctctgccctac	12	15	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:59113460G>A	uc001xdw.2	+	4	2283	c.2119G>A	c.(2119-2121)GCG>ACG	p.A707T	DACT1_uc010trv.1_Missense_Mutation_p.A426T|DACT1_uc001xdx.2_Missense_Mutation_p.A670T|DACT1_uc010trw.1_Missense_Mutation_p.A426T	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	707					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GCTGTACCCCGCGCCTGTGCC	0.672													0	0	0	0.00308	0	8	79										A	59113460	G	A	59113460	3	1	129	1	0	0	0	0	1	0	0	0	4222	1087	38	2	2133	2	DACT1	14	59113460	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	5599889	59113460	48236080	186	38558										
SPTB	6710	broad.mit.edu	37	chr14	65246625	65246625	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctcccccagctcctcttttcGcacattcacttggtcctcca	4	19	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:65246625G>C	uc001xht.2	-	20	4345	c.4291C>G	c.(4291-4293)CGA>GGA	p.R1431G	SPTB_uc001xhr.2_Missense_Mutation_p.R1431G|SPTB_uc001xhs.2_Missense_Mutation_p.R1431G|SPTB_uc001xhu.2_Missense_Mutation_p.R1431G|SPTB_uc010aqi.2_Missense_Mutation_p.R92G	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1431	Spectrin 11.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCCTCTTTTCGCACATTCACT	0.478													0	0	0	0.008291	0	10	125										C	65246625	G	C	65246625	3	2	129	1	0	0	0	0	1	0	0	0	15117	1095	38	4	2828	4	SPTB	14	65246625	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	6133165	65246625	42102915	187	38559										
PTPN21	11099	broad.mit.edu	37	chr14	88934487	88934487	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaaattgtgggagcttagatGagcctggagcttttcaggaa	14	5	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr14:88934487G>C	uc001xwv.3	-	19	3850	c.3519C>G	c.(3517-3519)CTC>CTG	p.L1173L	PTPN21_uc010twc.1_Silent_p.L969L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	1173						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GAGCTTAGATGAGCCTGGAGC	0.468													0	0	0	0.005524	0	39	247										C	88934487	G	C	88934487	2	2	129	1	0	0	0	0	0	0	0	1	12786	1277	45	1		1	PTPN21	14	88934487	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	23687862	88934487	18415053	188	38560										
TYRO3	7301	broad.mit.edu	37	chr15	41870164	41870164	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctgcgaatggaactggagaAcatcttgggccagctgtctg	13	9	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:41870164A>G	uc001zof.1	+	19	2587	c.2363A>G	c.(2362-2364)AAC>AGC	p.N788S		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	788	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GAACTGGAGAACATCTTGGGC	0.572													0	0	0	0.009096	0	4	109										G	41870164	A	G	41870164	3	3	129	1	0	0	0	0	1	0	0	0	16811	43	2	5	2437	5	TYRO3	15	41870164	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08		41870164	60661228	189	38561										
MYO9A	4649	broad.mit.edu	37	chr15	72172115	72172115	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctgccgaaattccttcagggCttttttaaatacaacatcca	5	11	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:72172115C>G	uc002atl.3	-	30	6159	c.5686G>C	c.(5686-5688)GCC>CCC	p.A1896P	MYO9A_uc002atk.2_Missense_Mutation_p.A691P|MYO9A_uc002atm.1_Missense_Mutation_p.A692P	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1896	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TCCTTCAGGGCTTTTTTAAAT	0.373													0	0	0	0.00308	0	8	58										G	72172115	C	G	72172115	3	3	129	1	0	0	0	0	1	0	0	0	10084	797	28	4	2012	4	MYO9A	15	72172115	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	30301951	72172115	30359277	190	38562										
CHRNB4	1143	broad.mit.edu	37	chr15	78922181	78922181	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaagggaaagtacttcacctCaatcttgcaggcgctcttgt	10	10	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr15:78922181C>G	uc002bed.1	-	5	578	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_5'UTR	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	156	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TACTTCACCTCAATCTTGCAG	0.567													0	0	0	0.008291	0	11	74										G	78922181	C	G	78922181	3	3	129	1	0	0	0	0	1	0	0	0	3393	835	29	1	1038	1	CHRNB4	15	78922181	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	6750066	78922181	23609211	191	38563										
MSLN	10232	broad.mit.edu	37	chr16	816647	816647	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	1	0	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctctccttgccacaaggctCctcggcggcccctcccacag	8	20	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:816647C>G	uc002cjw.1	+	13	1285	c.1234C>G	c.(1234-1236)CCT>GCT	p.P412A	MSLN_uc002cjt.1_Intron|MSLN_uc002cju.1_Intron|MSLN_uc010brd.1_Intron|MSLN_uc002cjv.1_Intron|MSLN_uc002cjx.1_Intron|MSLN_uc002cjy.1_Intron	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	412					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CCACAAGGCTCCTCGGCGGCC	0.632													0	0	0	0.003163	0	16	104										G	816647	C	G	816647	3	3	129	1	0	0	0	0	1	0	0	0	9881	855	30	1	1280	1	MSLN	16	816647	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		816647	89538106	192	38564										
TBC1D24	57465	broad.mit.edu	37	chr16	2546657	2546657	+	Frame_Shift_Del	DEL	G	G	-													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	accccggcaggaggctgatcGaccagagcttcctggccttt							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:2546657delG	uc002cql.2	+	2	648	c.508delG	c.(508-510)GACfs	p.D170fs	TBC1D24_uc002cqk.2_Frame_Shift_Del_p.D170fs|TBC1D24_uc002cqm.2_Frame_Shift_Del_p.D170fs|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	170	Rab-GAP TBC.				neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						GAGGCTGATCGACCAGAGCTT	0.632																		7	64	---	---								-	2546657	G	-	2546657	7	5	129	1	0	1	0	1	0	0	0	0	15611	1058	37	0	510	0	TBC1D24	16	2546657	Frame_Shift_Del	DEL	G	TCGA-K4-A3WU-01B-11D-A23M-08	1730010	2546657	87808096	193	38565										
DOC2A	8448	broad.mit.edu	37	chr16	30021406	30021406	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ggggcctccccgccgcccccGccgcccccttcaggtcctgg	12	23	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:30021406G>A	uc002dvm.2	-	2	238	c.138C>T	c.(136-138)GGC>GGT	p.G46G	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|DOC2A_uc002dvl.2_Silent_p.G46G|DOC2A_uc002dvn.2_Silent_p.G46G|DOC2A_uc010vef.1_Intron|DOC2A_uc002dvo.2_Silent_p.G46G|DOC2A_uc002dvp.2_Silent_p.G46G|DOC2A_uc002dvq.2_Silent_p.G46G	NM_003586	NP_003577	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	46	Interaction with UNC13D and DYNLT1.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			ovary(2)	2						cgccgcccccgccgcccccTT	0.567													0	0	0	0.010729	0	8	60										A	30021406	G	A	30021406	2	1	129	1	0	0	0	0	0	0	0	1	4683	1074	38	2		2	DOC2A	16	30021406	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	27474749	30021406	60333347	194	38566										
ADCY7	113	broad.mit.edu	37	chr16	50339459	50339459	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaggatgactcgtacgatgaCgagatgctgtcagccattga	13	8	1	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:50339459C>T	uc002egd.1	+	12	1909	c.1641C>T	c.(1639-1641)GAC>GAT	p.D547D	ADCY7_uc002egc.1_Silent_p.D547D	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	547	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CGTACGATGACGAGATGCTGT	0.597													0	0	0	0.008871	0	18	179										T	50339459	C	T	50339459	2	4	129	1	0	0	0	0	0	0	0	1	299	535	19	2		2	ADCY7	16	50339459	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	20318053	50339459	40015294	195	38567										
CHD9	80205	broad.mit.edu	37	chr16	53341818	53341818	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agtcaacacagatgtcaaagGtgaagaagcatgtacgagaa	11	6	2	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:53341818G>A	uc002ehb.2	+	32	7170	c.7006G>A	c.(7006-7008)GTG>ATG	p.V2336M	CHD9_uc002egy.2_Splice_Site_p.K2335_splice|CHD9_uc002ehc.2_Splice_Site_p.K2336_splice|CHD9_uc002ehf.2_Splice_Site_p.K1449_splice|CHD9_uc010cbw.2_Missense_Mutation_p.V402M|CHD9_uc002ehg.1_Missense_Mutation_p.V343M	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2336	Binds A/T-rich DNA.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				GATGTCAAAGGTGAAGAAGCA	0.473													0	0	0	0.000602	0	4	38										A	53341818	G	A	53341818	3	1	129	1	0	0	0	0	1	0	0	0	3332	1275	44	2	7132	2	CHD9	16	53341818	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3002359	53341818	37012935	196	38568										
NAE1	8883	broad.mit.edu	37	chr16	66860670	66860670	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttctaaagcctcttgcccatGatcaccccacaacctacaaa	3	16	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:66860670G>A	uc002eqf.2	-	2	144	c.67C>T	c.(67-69)CAT>TAT	p.H23Y	NAE1_uc002eqe.2_Missense_Mutation_p.H17Y|NAE1_uc002eqg.2_Intron|NAE1_uc010cdv.2_Missense_Mutation_p.H23Y|NAE1_uc010cdw.1_Intron	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	23					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TCTTGCCCATGATCACCCCAC	0.358													0	0	0	0.006214	0	10	84										A	66860670	G	A	66860670	3	1	129	1	0	0	0	0	1	0	0	0	10139	1290	45	1	1613	1	NAE1	16	66860670	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	13518852	66860670	23494083	197	38569										
KIAA0895L	653319	broad.mit.edu	37	chr16	67213339	67213339	+	Nonsense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acccacaccctgacctatctCatgccgcagcatgccctcca	5	20	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67213339C>A	uc002ert.2	-	4	1616	c.841G>T	c.(841-843)GAG>TAG	p.E281*	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'UTR|KIAA0895L_uc002eru.2_Nonsense_Mutation_p.E281*|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	281											0						TGACCTATCTCATGCCGCAGC	0.622													1	0	3.52763e-06	0.00499	3.71453e-06	13	121										A	67213339	C	A	67213339	4	1	129	1	0	0	0	0	0	1	0	0	8198	835	29	3	590	3	KIAA0895L	16	67213339	Nonsense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	352669	67213339	23141414	198	38570										
KIAA0895L	653319	broad.mit.edu	37	chr16	67213361	67213361	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgccgcagcatgccctccaaCcagtactggcgggctccggt	12	16	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67213361C>G	uc002ert.2	-	4	1594	c.819G>C	c.(817-819)TGG>TGC	p.W273C	KIAA0895L_uc002err.2_5'Flank|KIAA0895L_uc002ers.2_5'UTR|KIAA0895L_uc002eru.2_Missense_Mutation_p.W273C|EXOC3L_uc002erv.1_RNA	NM_001040715	NP_001035805	Q68EN5	K895L_HUMAN	hypothetical protein LOC653319	273											0						TGCCCTCCAACCAGTACTGGC	0.627													0	0	0	0.006122	0	11	105										G	67213361	C	G	67213361	3	3	129	1	0	0	0	0	1	0	0	0	8198	508	18	4	612	4	KIAA0895L	16	67213361	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	22	67213361	23141392	199	38571										
EXOC3L	283849	broad.mit.edu	37	chr16	67221161	67221161	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcagtgcccagtgcagcaagGcgaaggcatccgcagcttct	13	13	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:67221161G>T	uc002erx.1	-	5	1248	c.1007C>A	c.(1006-1008)GCC>GAC	p.A336D	EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Intron|EXOC3L_uc002ery.1_Missense_Mutation_p.A280D|EXOC3L_uc010vje.1_Missense_Mutation_p.A275D	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	336	Mediates interaction with EXOC2, EXOC4 and EXOC5 (By similarity).				exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		GTGCAGCAAGGCGAAGGCATC	0.627													1	0	2.17888e-05	0.006214	2.27922e-05	10	67										T	67221161	G	T	67221161	3	4	129	1	0	0	0	0	1	0	0	0	5304	1203	42	4	1273	4	EXOC3L	16	67221161	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	7800	67221161	23133592	200	38572										
DPEP3	64180	broad.mit.edu	37	chr16	68009821	68009821	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tggtgtccattctgaggcacGaggtgggagtggcaggatgt	18	6	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:68009821G>A	uc002evc.3	-	10	1483	c.1389C>T	c.(1387-1389)CTC>CTT	p.L463L	DPEP3_uc010cex.2_Silent_p.L462L	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	438					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TCTGAGGCACGAGGTGGGAGT	0.602													0	0	0	0.00308	0	7	55										A	68009821	G	A	68009821	2	1	129	1	0	0	0	0	0	0	0	1	4715	1045	37	1		1	DPEP3	16	68009821	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	788660	68009821	22344932	201	38573										
FUK	197258	broad.mit.edu	37	chr16	70513198	70513198	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atggatgtcctggccccccaCgtgcatggccagagcctggc	13	15	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:70513198C>T	uc002eyy.2	+	23	3103	c.3045C>T	c.(3043-3045)CAC>CAT	p.H1015H	FUK_uc010cft.2_Silent_p.H1021H|FUK_uc002eyz.2_Silent_p.H506H	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	1015						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				TGGCCCCCCACGTGCATGGCC	0.632													0	0	0	0.000602	0	4	75										T	70513198	C	T	70513198	2	4	129	1	0	0	0	0	0	0	0	1	6096	535	19	2		2	FUK	16	70513198	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2503377	70513198	19841555	202	38574										
MTHFSD	64779	broad.mit.edu	37	chr16	86565621	86565621	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtggctgtccacgaggtcacTtgtccctctgctgcctggcc	12	15	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr16:86565621T>C	uc002fjn.2	-	8	1199	c.1148A>G	c.(1147-1149)AAG>AGG	p.K383R	MTHFSD_uc010voo.1_Missense_Mutation_p.K363R|MTHFSD_uc002fjo.2_Missense_Mutation_p.K220R|MTHFSD_uc002fjm.2_Missense_Mutation_p.K382R|MTHFSD_uc010vop.1_Missense_Mutation_p.K220R|MTHFSD_uc010voq.1_Missense_Mutation_p.K382R|MTHFSD_uc010vor.1_Missense_Mutation_p.K383R	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	383					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						ACGAGGTCACTTGTCCCTCTG	0.701													0	0	0	0.004672	0	3	18										C	86565621	T	C	86565621	3	2	129	1	0	0	0	0	1	0	0	0	9933	1609	56	5	7	5	MTHFSD	16	86565621	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	16052423	86565621	3789132	203	38575										
GEMIN4	50628	broad.mit.edu	37	chr17	649462	649462	+	Silent	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttcatccagacggtttctttGaggcatgacaccatgaaagt	9	9	2	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:649462G>C	uc002frs.1	-	2	1940	c.1821C>G	c.(1819-1821)CTC>CTG	p.L607L		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	607					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CGGTTTCTTTGAGGCATGACA	0.502													0	0	0	0.008871	0	18	150										C	649462	G	C	649462	2	2	129	1	0	0	0	0	0	0	0	1	6330	1277	45	1		1	GEMIN4	17	649462	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08		649462	80545748	204	38576										
MNT	4335	broad.mit.edu	37	chr17	2290220	2290220	+	Frame_Shift_Del	DEL	G	G	-													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccagcttgagtgtgctgactGggaaggagggcatggtgacc							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:2290220delG	uc002fur.2	-	6	1976	c.1724delC	c.(1723-1725)CCAfs	p.P575fs		NM_020310	NP_064706	Q99583	MNT_HUMAN	MAX binding protein	575					multicellular organismal development|negative regulation of cell proliferation|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			skin(1)	1				Colorectal(2;1.37e-05)|READ - Rectum adenocarcinoma(2;8.68e-05)		TGTGCTGACTGGGAAGGAGGG	0.667																		2	4	---	---								-	2290220	G	-	2290220	7	5	129	1	0	1	0	1	0	0	0	0	9678	1348	47	0	28	0	MNT	17	2290220	Frame_Shift_Del	DEL	G	TCGA-K4-A3WU-01B-11D-A23M-08	1640758	2290220	78904990	205	38577										
PFN1	5216	broad.mit.edu	37	chr17	4849269	4849269	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	caaaccaccgtggacaccttCtttgcccatcagcaggacta	7	15	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:4849269C>G	uc002gaa.2	-	3	485	c.349G>C	c.(349-351)GAA>CAA	p.E117Q	PFN1_uc002fzz.2_Missense_Mutation_p.E81Q	NM_005022	NP_005013	P07737	PROF1_HUMAN	profilin 1	117					actin cytoskeleton organization|platelet activation|platelet degranulation	actin cytoskeleton|cytoplasm	actin binding|proline-rich region binding				0						TGGACACCTTCTTTGCCCATC	0.552													0	0	0	0.003163	0	15	65										G	4849269	C	G	4849269	3	3	129	1	0	0	0	0	1	0	0	0	11767	922	32	1	77	1	PFN1	17	4849269	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2559049	4849269	76345941	206	38578										
CAMTA2	23125	broad.mit.edu	37	chr17	4876139	4876139	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctcctgtctctgtagttcctCaaggcagcgggcaaggcgca	12	13	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:4876139C>G	uc002gah.1	-	15	2536	c.2428G>C	c.(2428-2430)GAG>CAG	p.E810Q	CAMTA2_uc010cku.1_Missense_Mutation_p.E833Q|CAMTA2_uc002gag.1_Missense_Mutation_p.E809Q|CAMTA2_uc002gai.1_Missense_Mutation_p.E812Q|CAMTA2_uc010ckv.1_Missense_Mutation_p.E457Q	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	810	ANK 3.				cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						TGTAGTTCCTCAAGGCAGCGG	0.612													0	0	0	0.01441	0	50	164										G	4876139	C	G	4876139	3	3	129	1	0	0	0	0	1	0	0	0	2614	835	29	1	1266	1	CAMTA2	17	4876139	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	26870	4876139	76319071	207	38579										
FBXO39	162517	broad.mit.edu	37	chr17	6683806	6683806	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcgaggactatttcagccatCaccttgctgtctacaacagc	7	13	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:6683806C>T	uc010vtg.1	+	2	739	c.619C>T	c.(619-621)CAC>TAC	p.H207Y		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	207										ovary(1)|skin(1)	2						TTTCAGCCATCACCTTGCTGT	0.493													0	0	0	0.00245	0	15	81										T	6683806	C	T	6683806	3	4	129	1	0	0	0	0	1	0	0	0	5747	826	29	1	621	1	FBXO39	17	6683806	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1807667	6683806	74511404	208	38580										
BCL6B	255877	broad.mit.edu	37	chr17	6928501	6928501	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cctctggatcaccctctgaaCgggctcgtccactaccgggt	10	16	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:6928501C>T	uc002geg.2	+	5	928	c.871C>T	c.(871-873)CGG>TGG	p.R291W	BCL6B_uc010clt.1_Missense_Mutation_p.R292W	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	291						nucleus	zinc ion binding			skin(1)	1						ACCCTCTGAACGGGCTCGTCC	0.557													0	0	0	0.006214	0	10	158										T	6928501	C	T	6928501	3	4	129	1	0	0	0	0	1	0	0	0	1377	527	19	2	885	2	BCL6B	17	6928501	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	244695	6928501	74266709	209	38581										
NTN1	9423	broad.mit.edu	37	chr17	8925911	8925911	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cagcacctgcggccggccccCggcgcgctactgcgtggtga	15	17	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:8925911C>T	uc002glw.3	+	2	328	c.221C>T	c.(220-222)CCG>CTG	p.P74L		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	74	Laminin N-terminal.				apoptosis|axon guidance		protein binding				0						GGCCGGCCCCCGGCGCGCTAC	0.726													0	0	0	0.004672	0	3	10										T	8925911	C	T	8925911	3	4	129	1	0	0	0	0	1	0	0	0	10700	652	23	2	223	2	NTN1	17	8925911	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1997410	8925911	72269299	210	38582										
GLP2R	9340	broad.mit.edu	37	chr17	9729386	9729386	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aggtgcacgaggaagatgaaGctgggatcgagcagggcagg	19	6	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:9729386G>C	uc002gmd.1	+	1	6	c.6G>C	c.(4-6)AAG>AAC	p.K2N	GLP2R_uc010cog.1_RNA	NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	2	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GGAAGATGAAGCTGGGATCGA	0.632													0	0	0	0.001984	0	6	26										C	9729386	G	C	9729386	3	2	129	1	0	0	0	0	1	0	0	0	6453	962	34	4	8	4	GLP2R	17	9729386	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	803475	9729386	71465824	211	38583										
HDAC5	10014	broad.mit.edu	37	chr17	42171034	42171034	+	Missense_Mutation	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acaggagctgcttctgcagcTgctgctgctgcttgagcgcc	13	13	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:42171034T>A	uc002ifd.1	-	4	474	c.263A>T	c.(262-264)CAG>CTG	p.Q88L	HDAC5_uc002ife.1_Missense_Mutation_p.Q88L|HDAC5_uc002iff.1_Missense_Mutation_p.Q89L|HDAC5_uc010czp.1_Missense_Mutation_p.Q88L|HDAC5_uc002ifh.2_Missense_Mutation_p.Q88L	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	88	Poly-Gln.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		cttctgcagctgctgctgctg	0.408													0	0	0	0.004672	0	3	32										A	42171034	T	A	42171034	3	1	129	1	0	0	0	0	1	0	0	0	7010	1580	55	5	3201	5	HDAC5	17	42171034	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	32441648	42171034	39024176	212	38584										
XYLT2	64132	broad.mit.edu	37	chr17	48431297	48431297	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acggagatacagggagcgtgGagggcgccccccagcccacg	16	14	0	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:48431297G>C	uc002iqo.2	+	2	551	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	148	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AGGGAGCGTGGAGGGCGCCCC	0.692													0	0	0	0.004482	0	9	47										C	48431297	G	C	48431297	3	2	129	1	0	0	0	0	1	0	0	0	17461	1175	41	1	448	1	XYLT2	17	48431297	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	6260263	48431297	32763913	213	38585										
NACA2	342538	broad.mit.edu	37	chr17	59668370	59668370	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gactggttcttcatcaatttCagctgctgccaccagccagg	9	13	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:59668370C>T	uc002izj.2	-	1	198	c.172G>A	c.(172-174)GAA>AAA	p.E58K		NM_199290	NP_954984	Q9H009	NACA2_HUMAN	nascent-polypeptide-associated complex alpha	58					protein transport	cytoplasm|nucleus				ovary(1)	1	all_epithelial(1;3.12e-14)					TCATCAATTTCAGCTGCTGCC	0.493													0	0	0	0.003755	0	37	165										T	59668370	C	T	59668370	3	4	129	1	0	0	0	0	1	0	0	0	10134	835	29	1	479	1	NACA2	17	59668370	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	11237073	59668370	21526840	214	38586										
H3F3B	3021	broad.mit.edu	37	chr17	73774687	73774687	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgccttcacttaagctctctCtccccgtatccggcgagcca	7	17	3	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:73774687C>G	uc002jpl.2	-	4	533	c.400G>C	c.(400-402)GAG>CAG	p.E134Q		NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	134					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			ovary(1)	1	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TAAGCTCTCTCTCCCCGTATC	0.418													0	0	0	0.010818	0	32	132										G	73774687	C	G	73774687	3	3	129	1	0	0	0	0	1	0	0	0	6934	922	32	1	14	1	H3F3B	17	73774687	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	14106317	73774687	7420523	215	38587										
UNC13D	201294	broad.mit.edu	37	chr17	73824054	73824054	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	aaacctctacggctacggtgCcggccgcaaggcatgctggg	14	13	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:73824054C>T	uc002jpp.2	-	32	3645	c.3265G>A	c.(3265-3267)GCA>ACA	p.A1089T		NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	1089					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCTACGGTGCCGGCCGCAAG	0.697									Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.004672	0	3	24										T	73824054	C	T	73824054	3	4	129	1	0	0	0	0	1	0	0	0	16984	739	26	2	11	2	UNC13D	17	73824054	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	49367	73824054	7371156	216	38588										
TMC6	11322	broad.mit.edu	37	chr17	76120607	76120607	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtcctagggcttcctcaccgCgcctgtgaggagctccaggc	13	15	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:76120607C>T	uc002juj.1	-	7	1015	c.889G>A	c.(889-891)GCG>ACG	p.A297T	TMC6_uc002jui.1_5'Flank|TMC6_uc010dhf.1_Missense_Mutation_p.A130T|TMC6_uc002juk.2_Missense_Mutation_p.A297T|TMC6_uc010dhg.1_Missense_Mutation_p.A297T|TMC6_uc002jul.1_Missense_Mutation_p.A297T|TMC6_uc002jum.3_Missense_Mutation_p.A88T|TMC6_uc002jun.3_Missense_Mutation_p.A297T|TMC6_uc002juo.2_Missense_Mutation_p.A70T|TMC6_uc010wtp.1_Missense_Mutation_p.A130T	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	297	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TTCCTCACCGCGCCTGTGAGG	0.697									Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.001984	0	6	38										T	76120607	C	T	76120607	3	4	129	1	0	0	0	0	1	0	0	0	15986	768	27	2	1580	2	TMC6	17	76120607	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2296553	76120607	5074603	217	38589										
BAHCC1	57597	broad.mit.edu	37	chr17	79426591	79426591	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gggtctgcgcctactggagtCagaagtctcgatgtctgtac	13	10	4	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:79426591C>G	uc002kaf.2	+	21	5866	c.5866C>G	c.(5866-5868)CAG>GAG	p.Q1956E	BAHCC1_uc002kae.2_Missense_Mutation_p.Q1186E	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1956							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CTACTGGAGTCAGAAGTCTCG	0.657													0	0	0	0.003163	0	14	98										G	79426591	C	G	79426591	3	3	129	1	0	0	0	0	1	0	0	0	1296	827	29	1	5787	1	BAHCC1	17	79426591	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	3305984	79426591	1768619	218	38590										
FSCN2	25794	broad.mit.edu	37	chr17	79503966	79503966	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcagcgacggcgaacgcgccGaggacttcgtcttcgagttc	14	13	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr17:79503966G>C	uc010wup.1	+	5	1480	c.1339G>C	c.(1339-1341)GAG>CAG	p.E447Q	FSCN2_uc010wuo.1_Missense_Mutation_p.E471Q	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	447					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CGAACGCGCCGAGGACTTCGT	0.761													0	0	0	0.001168	0	6	14										C	79503966	G	C	79503966	3	2	129	1	0	0	0	0	1	0	0	0	6068	1059	37	1	1268	1	FSCN2	17	79503966	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	77375	79503966	1691244	219	38591										
ENOSF1	55556	broad.mit.edu	37	chr18	691231	691231	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	atcctcctcagtcaggacatCagtgatgtacctgaaatcta	7	11	4	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:691231C>T	uc002kku.3	-	6	544	c.469G>A	c.(469-471)GAT>AAT	p.D157N	ENOSF1_uc002kkt.3_Missense_Mutation_p.D75N|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Missense_Mutation_p.D178N|ENOSF1_uc002kkv.3_Missense_Mutation_p.D157N|ENOSF1_uc002kkw.3_Intron|ENOSF1_uc002kkx.3_Intron|ENOSF1_uc010wyt.1_RNA	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	157					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						GTCAGGACATCAGTGATGTAC	0.483													0	0	0	0.001168	0	5	83										T	691231	C	T	691231	3	4	129	1	0	0	0	0	1	0	0	0	5125	826	29	1	906	1	ENOSF1	18	691231	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		691231	77386017	220	38592										
LAMA3	3909	broad.mit.edu	37	chr18	21427492	21427492	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgccgctgccctccccgcacGgtcaggccccagtgtgaggt	13	17	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:21427492G>A	uc002kuq.2	+	32	4082	c.3996G>A	c.(3994-3996)ACG>ACA	p.T1332T	LAMA3_uc002kur.2_Silent_p.T1332T	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1332	Laminin EGF-like 10.|Domain III B.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCCCCGCACGGTCAGGCCCC	0.622													0	0	0	0.00308	0	8	78										A	21427492	G	A	21427492	2	1	129	1	0	0	0	0	0	0	0	1	8607	1103	39	2		2	LAMA3	18	21427492	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	20736261	21427492	56649756	221	38593										
SMAD7	4092	broad.mit.edu	37	chr18	46476250	46476250	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cggggttgatcttcccgtaaGattcacagcaacacagcctc	9	13	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:46476250G>C	uc002ldg.2	-	1	832	c.545C>G	c.(544-546)TCT>TGT	p.S182C	SMAD7_uc010xde.1_5'Flank	NM_005904	NP_005895	O15105	SMAD7_HUMAN	SMAD family member 7	182	MH1.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding				0	Colorectal(1;0.0518)					CTTCCCGTAAGATTCACAGCA	0.572											OREG0024975	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	53										C	46476250	G	C	46476250	3	2	129	1	0	0	0	0	1	0	0	0	14763	942	33	1	751	1	SMAD7	18	46476250	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	25048758	46476250	31600998	222	38594										
KCNG2	26251	broad.mit.edu	37	chr18	77659423	77659423	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tgcgtggccatggcgctcttCgcgccactggtgcacctggc	14	15	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr18:77659423C>T	uc010xfl.1	+	2	1008	c.1008C>T	c.(1006-1008)TTC>TTT	p.F336F		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	336	Helical; Name=Segment S5; (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		TGGCGCTCTTCGCGCCACTGG	0.716													0	0	0	0.000602	0	5	11										T	77659423	C	T	77659423	2	4	129	1	0	0	0	0	0	0	0	1	8028	883	31	1		1	KCNG2	18	77659423	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	31183173	77659423	417825	223	38595										
SGTA	6449	broad.mit.edu	37	chr19	2762518	2762518	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	actcacggggctgggggcctCccgcagcttcagctccgcta	13	16	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:2762518C>T	uc002lwi.1	-	7	769	c.622G>A	c.(622-624)GAG>AAG	p.E208K		NM_003021	NP_003012	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide	208					interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGGGGCCTCCCGCAGCTTC	0.647													0	0	0	0.010729	0	12	111										T	2762518	C	T	2762518	3	4	129	1	0	0	0	0	1	0	0	0	14225	864	30	1	339	1	SGTA	19	2762518	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		2762518	56366465	224	38596										
LRG1	116844	broad.mit.edu	37	chr19	4538457	4538457	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agttggccagcagcccggggGgcagtttccggaggcggttc	18	11	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:4538457G>T	uc002mau.2	-	2	550	c.539C>A	c.(538-540)CCC>CAC	p.P180H	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	180	LRR 4.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCCGGGGGGCAGTTTCCG	0.622													1	0	1.96895e-08	0.00278	2.11529e-08	25	265										T	4538457	G	T	4538457	3	4	129	1	0	0	0	0	1	0	0	0	8942	1232	43	4	508	4	LRG1	19	4538457	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1775939	4538457	54590526	225	38597										
FBN3	84467	broad.mit.edu	37	chr19	8152753	8152753	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcagggtgtagccggctggaCaggtgcacaggtaggagccc	18	10	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:8152753C>G	uc002mjf.2	-	52	6596	c.6575G>C	c.(6574-6576)TGT>TCT	p.C2192S	FBN3_uc002mje.2_Missense_Mutation_p.C31S	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2192	EGF-like 35; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCCGGCTGGACAGGTGCACAG	0.453													0	0	0	0.013537	0	12	157										G	8152753	C	G	8152753	3	3	129	1	0	0	0	0	1	0	0	0	5704	478	17	4	1902	4	FBN3	19	8152753	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	3614296	8152753	50976230	226	38598										
MYO1F	4542	broad.mit.edu	37	chr19	8591788	8591788	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gaagctgtcggcggcatcctCttggaggatgaagaagtcgt	15	8	1	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:8591788C>G	uc002mkg.2	-	23	2620	c.2506G>C	c.(2506-2508)GAG>CAG	p.E836Q		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	836						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GCGGCATCCTCTTGGAGGATG	0.627													0	0	0	0.000602	0	5	63										G	8591788	C	G	8591788	3	3	129	1	0	0	0	0	1	0	0	0	10073	922	32	1	814	1	MYO1F	19	8591788	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	439035	8591788	50537195	227	38599										
ZNF846	162993	broad.mit.edu	37	chr19	9868414	9868414	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cttacattcacaggccttttCtccagtgtgagttcttaaat	6	10	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:9868414C>T	uc002mmb.1	-	6	1870	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	ZNF846_uc010xky.1_Intron|ZNF846_uc010xkz.1_Intron|ZNF846_uc010dww.2_Intron|ZNF846_uc002mmc.1_Missense_Mutation_p.E318K	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGGCCTTTTCTCCAGTGTGA	0.438													0	0	0	0.00499	0	17	69										T	9868414	C	T	9868414	3	4	129	1	0	0	0	0	1	0	0	0	18189	922	32	1	266	1	ZNF846	19	9868414	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1276626	9868414	49260569	228	38600										
TYK2	7297	broad.mit.edu	37	chr19	10475384	10475384	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gctggagtcggccgtcaggcGgaaatagccgtccaccagcg	15	13	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:10475384G>A	uc002moc.3	-	9	1651	c.1273C>T	c.(1273-1275)CGC>TGC	p.R425C	TYK2_uc010dxe.2_Missense_Mutation_p.R240C|TYK2_uc002mod.2_Missense_Mutation_p.R425C	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	425	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GCCGTCAGGCGGAAATAGCCG	0.672													0	0	0	0.014323	0	22	79										A	10475384	G	A	10475384	3	1	129	1	0	0	0	0	1	0	0	0	16807	1116	39	2	2358	2	TYK2	19	10475384	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	606970	10475384	48653599	229	38601										
ARRDC2	27106	broad.mit.edu	37	chr19	18120728	18120728	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cgggcagtggtggccagcctCgcgggcgagccggtgggccc	20	14	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:18120728C>T	uc002nhv.2	+	5	872	c.729C>T	c.(727-729)CTC>CTT	p.L243L	ARRDC2_uc002nhu.2_Silent_p.L238L	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2 isoform 1	243										pancreas(1)	1						TGGCCAGCCTCGCGGGCGAGC	0.716													0	0	0	0.00308	0	8	96										T	18120728	C	T	18120728	2	4	129	1	0	0	0	0	0	0	0	1	983	871	31	1		1	ARRDC2	19	18120728	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	7645344	18120728	41008255	230	38602										
ARHGAP33	115703	broad.mit.edu	37	chr19	36278974	36278974	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acaccgcctgagcccctctaCgtcaacctagctctagggcc	8	18	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:36278974C>T	uc002obs.1	+	21	3109	c.3024C>T	c.(3022-3024)TAC>TAT	p.Y1008Y	ARHGAP33_uc002obt.1_Silent_p.Y1005Y|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Silent_p.Y757Y	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1169					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						AGCCCCTCTACGTCAACCTAG	0.682													0	0	0	0.003163	0	15	80										T	36278974	C	T	36278974	2	4	129	1	0	0	0	0	0	0	0	1	882	547	19	2		2	ARHGAP33	19	36278974	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	18158246	36278974	22850009	231	38603										
LIPE	3991	broad.mit.edu	37	chr19	42910494	42910494	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gccacggtgaagcagaggttCccgcctgcactgtcccccgc	12	17	0	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:42910494C>T	uc002otr.2	-	7	2461	c.2184G>A	c.(2182-2184)GGG>GGA	p.G728G	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	728					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				AGCAGAGGTTCCCGCCTGCAC	0.662													0	0	0	0.001984	0	7	42										T	42910494	C	T	42910494	2	4	129	1	0	0	0	0	0	0	0	1	8821	842	30	1		1	LIPE	19	42910494	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	6631520	42910494	16218489	232	38604										
NKPD1	284353	broad.mit.edu	37	chr19	45656023	45656023	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccccggcagccacggcttgcGcgtcatctcgcggtacaaca	11	17	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:45656023G>A	uc010xxi.1	-	4	1672	c.1672C>T	c.(1672-1674)CGC>TGC	p.R558C		NM_198478	NP_940880			NTPase, KAP family P-loop domain containing 1												0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00863)|GBM - Glioblastoma multiforme(486;0.231)		CACGGCTTGCGCGTCATCTCG	0.721													0	0	0	0.001168	0	5	16										A	45656023	G	A	45656023	3	1	129	1	0	0	0	0	1	0	0	0	10446	1087	38	2	830	2	NKPD1	19	45656023	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2745529	45656023	13472960	233	38605										
CCDC9	26093	broad.mit.edu	37	chr19	47773835	47773835	+	Silent	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	caggcctgggcccggcccccGaagccccctacttttgggga	13	17	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:47773835G>A	uc010xym.1	+	10	1182	c.975G>A	c.(973-975)CCG>CCA	p.P325P		NM_015603	NP_056418	Q9Y3X0	CCDC9_HUMAN	coiled-coil domain containing 9	325											0		all_cancers(25;0.0432)|all_epithelial(76;0.00812)|Medulloblastoma(540;0.0208)|all_neural(266;0.0416)|Hepatocellular(1079;0.114)		OV - Ovarian serous cystadenocarcinoma(262;8.51e-95)|Epithelial(262;1.15e-92)|all cancers(93;7.67e-84)|GBM - Glioblastoma multiforme(486;0.024)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCGGCCCCCGAAGCCCCCTA	0.642													0	0	0	0.010729	0	9	109										A	47773835	G	A	47773835	2	1	129	1	0	0	0	0	0	0	0	1	2867	1045	37	1		1	CCDC9	19	47773835	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	2117812	47773835	11355148	234	38606										
SIGLEC9	27180	broad.mit.edu	37	chr19	51628543	51628543	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cataccaagaattgcaccctGagcatcagagatgccagaag	9	11	1	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:51628543G>A	uc002pvu.2	+	1	379	c.312G>A	c.(310-312)CTG>CTA	p.L104L	SIGLEC9_uc010yct.1_Silent_p.L104L	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	104	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATTGCACCCTGAGCATCAGAG	0.507													0	0	0	0.006122	0	19	115										A	51628543	G	A	51628543	2	1	129	1	0	0	0	0	0	0	0	1	14315	1277	45	1		1	SIGLEC9	19	51628543	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	3854708	51628543	7500440	235	38607										
ZNF524	147807	broad.mit.edu	37	chr19	56113573	56113573	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcctgttccccggggccgccGaggccgtcgtcctgggggag	17	15	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:56113573G>A	uc002qlk.1	+	2	178	c.95G>A	c.(94-96)CGA>CAA	p.R32Q	FIZ1_uc002qli.3_5'Flank|FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGGGCCGCCGAGGCCGTCGT	0.682													0	0	0	0.00308	0	8	45										A	56113573	G	A	56113573	3	1	129	1	0	0	0	0	1	0	0	0	17963	1058	37	1	97	1	ZNF524	19	56113573	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	4485030	56113573	3015410	236	38608										
PEG3	5178	broad.mit.edu	37	chr19	57335705	57335705	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gttctccggcttttttgctcGcacccaaggcttgagctttt	9	12	1	1	rs141346770	by1000genomes	TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:57335705G>T	uc002qnu.2	-	1	670	c.319C>A	c.(319-321)CGA>AGA	p.R107R	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Silent_p.R107R|PEG3_uc002qnv.2_Silent_p.R107R|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Silent_p.R107R	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	107	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTTTTGCTCGCACCCAAGGC	0.537													1	0	0.00136819	0.013537	0.00140804	13	154										T	57335705	G	T	57335705	2	4	129	1	0	0	0	0	0	0	0	1	11720	1095	38	4		4	PEG3	19	57335705	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	1222132	57335705	1793278	237	38609										
ZNF551	90233	broad.mit.edu	37	chr19	58198725	58198725	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gagagttcacactggagaaaGgccttatgaatgtggcgagt	14	6	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:58198725G>A	uc002qpw.3	+	3	1257	c.1034G>A	c.(1033-1035)AGG>AAG	p.R345K	ZNF551_uc002qpv.3_Missense_Mutation_p.R288K|ZNF776_uc002qpx.2_Intron	NM_138347	NP_612356	Q7Z340	ZN551_HUMAN	zinc finger protein 551	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ACTGGAGAAAGGCCTTATGAA	0.468													0	0	0	0.010729	0	11	141										A	58198725	G	A	58198725	3	1	129	1	0	0	0	0	1	0	0	0	17980	1000	35	2	1044	2	ZNF551	19	58198725	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	863020	58198725	930258	238	38610										
ZNF329	79673	broad.mit.edu	37	chr19	58639742	58639742	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtttctgttgaaggatttccCgcactctgcacactcaaagg	9	11	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr19:58639742C>T	uc002qrn.2	-	4	1366	c.1129G>A	c.(1129-1131)GGG>AGG	p.G377R	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	377	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		AAGGATTTCCCGCACTCTGCA	0.478													0	0	0	0.013537	0	12	137										T	58639742	C	T	58639742	3	4	129	1	0	0	0	0	1	0	0	0	17844	652	23	2	500	2	ZNF329	19	58639742	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	441017	58639742	489241	239	38611										
ProSAPiP1	9762	broad.mit.edu	37	chr20	3146671	3146671	+	Silent	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tcctggtagcccgaccccccAccgctgctgccgccactacc	8	22	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:3146671A>C	uc002wia.1	-	2	2193	c.795T>G	c.(793-795)GGT>GGG	p.G265G	ProSAPiP1_uc002wib.1_Silent_p.G265G	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	265						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						CCGACCCCCCACCGCTGCTGC	0.657													0	0	0	0.008871	0	6	46										C	3146671	A	C	3146671	2	2	129	1	0	0	0	0	0	0	0	1	12870	146	6	5		5	ProSAPiP1	20	3146671	Silent	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08		3146671	59878849	240	38612										
C20orf194	25943	broad.mit.edu	37	chr20	3270794	3270794	+	Missense_Mutation	SNP	G	G	C	1	0	0	1	0	1	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cctgccacattccttatgcaGagtgaccagaaaagcacaga	8	12	0	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:3270794G>C	uc002wii.2	-	26	2359	c.2308C>G	c.(2308-2310)CTG>GTG	p.L770V	C20orf194_uc002wij.3_Missense_Mutation_p.L509V|C20orf194_uc002wik.2_Missense_Mutation_p.L444V	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	770											0						TCCTTATGCAGAGTGACCAGA	0.478													0	0	0	0.009718	0	42	310										C	3270794	G	C	3270794	3	2	129	1	0	0	0	0	1	0	0	0	2099	933	33	1	1273	1	C20orf194	20	3270794	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	124123	3270794	59754726	241	38613										
KIF16B	55614	broad.mit.edu	37	chr20	16359644	16359644	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcccgctccagcgcctctctCtgctgcttctctctggactc	8	19	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:16359644C>G	uc002wpg.1	-	19	3161	c.3003G>C	c.(3001-3003)CAG>CAC	p.Q1001H	KIF16B_uc002wpe.1_Missense_Mutation_p.Q383H|KIF16B_uc002wpf.1_Missense_Mutation_p.Q383H|KIF16B_uc010gch.1_Missense_Mutation_p.Q1001H|KIF16B_uc010gci.1_Missense_Mutation_p.Q1001H|KIF16B_uc010gcj.1_Missense_Mutation_p.Q1012H	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1001	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GCGCCTCTCTCTGCTGCTTCT	0.552													0	0	0	0.00499	0	18	164										G	16359644	C	G	16359644	3	3	129	1	0	0	0	0	1	0	0	0	8278	912	32	1	982	1	KIF16B	20	16359644	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	13088850	16359644	46665876	242	38614										
NINL	22981	broad.mit.edu	37	chr20	25456923	25456923	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cccaggctccagggcgccctCggcccgggcctgctgctccg	14	20	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:25456923C>T	uc002wux.1	-	17	3078	c.3004G>A	c.(3004-3006)GAG>AAG	p.E1002K	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1002					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						AGGGCGCCCTCGGCCCGGGCC	0.677													0	0	0	0.013537	0	12	94										T	25456923	C	T	25456923	3	4	129	1	0	0	0	0	1	0	0	0	10420	893	31	1	1176	1	NINL	20	25456923	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	9097279	25456923	37568597	243	38615										
WFDC3	140686	broad.mit.edu	37	chr20	44416554	44416554	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttctttacacctggacatgtCtcatcagtgatgcacctttt	6	11	3	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:44416554C>G	uc002xpf.1	-	4	363	c.279G>C	c.(277-279)GAG>GAC	p.E93D	WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_RNA	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	93	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CTGGACATGTCTCATCAGTGA	0.463													0	0	0	0.001168	0	6	73										G	44416554	C	G	44416554	3	3	129	1	0	0	0	0	1	0	0	0	17350	912	32	1	432	1	WFDC3	20	44416554	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	18959631	44416554	18608966	244	38616										
WFDC3	140686	broad.mit.edu	37	chr20	44417657	44417657	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttcatcaccctggcacagctCtttgcatgggttcttatggg	10	11	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:44417657C>G	uc002xpf.1	-	3	208	c.124G>C	c.(124-126)GAG>CAG	p.E42Q	DNTTIP1_uc002xpk.2_5'Flank|WFDC3_uc002xpj.1_RNA|WFDC3_uc002xph.1_RNA|WFDC3_uc010ghh.1_Intron	NM_080614	NP_542181	Q8IUB2	WFDC3_HUMAN	WAP four-disulfide core domain 3 precursor	42	WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				TGGCACAGCTCTTTGCATGGG	0.512													0	0	0	0.006122	0	16	249										G	44417657	C	G	44417657	3	3	129	1	0	0	0	0	1	0	0	0	17350	922	32	1	591	1	WFDC3	20	44417657	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	1103	44417657	18607863	245	38617										
CTCFL	140690	broad.mit.edu	37	chr20	56098314	56098314	+	Silent	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ctttcagccaataactggttCttctcctgctcttcctcgag	6	14	4	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr20:56098314C>T	uc010gix.1	-	2	1226	c.564G>A	c.(562-564)AAG>AAA	p.K188K	CTCFL_uc010giw.1_Silent_p.K188K|CTCFL_uc002xym.2_Silent_p.K188K|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Silent_p.K188K|CTCFL_uc010gjb.1_Silent_p.K188K|CTCFL_uc010gjc.1_Silent_p.K188K|CTCFL_uc010gjd.1_Silent_p.K188K|CTCFL_uc010gje.2_Silent_p.K188K|CTCFL_uc010gjf.2_5'UTR|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Silent_p.K188K|CTCFL_uc010gji.1_5'UTR|CTCFL_uc010gjj.1_Silent_p.K188K|CTCFL_uc010gjk.1_Silent_p.K188K|CTCFL_uc010gjl.1_Silent_p.K188K	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	188					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ATAACTGGTTCTTCTCCTGCT	0.353													0	0	0	0.008291	0	11	74										T	56098314	C	T	56098314	2	4	129	1	0	0	0	0	0	0	0	1	4001	912	32	1		1	CTCFL	20	56098314	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	11680657	56098314	6927206	246	38618										
DSCAM	1826	broad.mit.edu	37	chr21	41684108	41684108	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	agcgagagattggaaatcctCaaggagctcgtgaagtcaat	12	7	2	2			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:41684108C>G	uc002yyq.1	-	9	2414	c.1962G>C	c.(1960-1962)TTG>TTC	p.L654F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	654	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGAAATCCTCAAGGAGCTCG	0.547													0	0	0	0.001168	0	6	133										G	41684108	C	G	41684108	3	3	129	1	0	0	0	0	1	0	0	0	4768	825	29	1	4176	1	DSCAM	21	41684108	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		41684108	6445787	247	38619										
KRTAP10-11	386678	broad.mit.edu	37	chr21	46066950	46066950	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gcaggcctgctgcgtgcctgTctgctgcaagactgtctact	12	13	2	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr21:46066950T>C	uc002zfr.3	+	1	620	c.575T>C	c.(574-576)GTC>GCC	p.V192A	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	192	25 X 5 AA repeats of C-C-X(3).|18.					keratin filament				ovary(1)	1						TGCGTGCCTGTCTGCTGCAAG	0.607													0	0	0	0.008361	0	31	399										C	46066950	T	C	46066950	3	2	129	1	0	0	0	0	1	0	0	0	8507	1667	58	5	577	5	KRTAP10-11	21	46066950	Missense_Mutation	SNP	T	TCGA-K4-A3WU-01B-11D-A23M-08	4382842	46066950	2062945	248	38620										
PLXNB2	23654	broad.mit.edu	37	chr22	50720031	50720031	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ttgtgtgtggtgtctcgtttCtgccgccgcttgggcggggg	18	9	2	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chr22:50720031C>G	uc003bkv.3	-	21	3592	c.3486G>C	c.(3484-3486)CAG>CAC	p.Q1162H	PLXNB2_uc003bkt.1_5'UTR|PLXNB2_uc003bku.1_Missense_Mutation_p.Q147H	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1162	Extracellular (Potential).			RQKR->AQKA: Abolishes cleavage by proprotein convertases.	regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGTCTCGTTTCTGCCGCCGCT	0.697													0	0	0	0.007413	0	16	77										G	50720031	C	G	50720031	3	3	129	1	0	0	0	0	1	0	0	0	12124	912	32	1	2098	1	PLXNB2	22	50720031	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08		50720031	584535	249	38621										
MXRA5	25878	broad.mit.edu	37	chrX	3238516	3238516	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	ccaactgtggaaaagaaagaGtcttgttggtaaagaaaggg	13	4	1	3			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:3238516G>C	uc004crg.3	-	5	5367	c.5210C>G	c.(5209-5211)ACT>AGT	p.T1737S		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1737						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAAAGAAAGAGTCTTGTTGGT	0.463													0	0	0	0.014323	0	24	28										C	3238516	G	C	3238516	3	2	129	1	0	0	0	0	1	0	0	0	10003	1029	36	4	3288	4	MXRA5	23	3238516	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08		3238516	152032044	250	38622										
USP11	8237	broad.mit.edu	37	chrX	47092454	47092454	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	cggacggcgatggcgacggtCgcagcaaatccagctgctgc	15	13	0	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:47092454C>T	uc004dhp.2	+	1	141	c.141C>T	c.(139-141)GTC>GTT	p.V47V		NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	47					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						tggcgacggtcgcagcaaatc	0.383													0	0	0	0.00308	0	7	16										T	47092454	C	T	47092454	2	4	129	1	0	0	0	0	0	0	0	1	17039	871	31	1		1	USP11	23	47092454	Silent	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	43853938	47092454	108178106	251	38623										
APEX2	27301	broad.mit.edu	37	chrX	55033806	55033806	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	tctacatgtgtgccaggcccCggggtcctcccactgacccc	10	18	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:55033806C>T	uc004dtz.2	+	6	1571	c.1495C>T	c.(1495-1497)CGG>TGG	p.R499W	APEX2_uc011mom.1_Missense_Mutation_p.R328W	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	499					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						TGCCAGGCCCCGGGGTCCTCC	0.642								Other_BER_factors					0	0	0	0.009096	0	4	13										T	55033806	C	T	55033806	3	4	129	1	0	0	0	0	1	0	0	0	770	643	23	2	1517	2	APEX2	23	55033806	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	7941352	55033806	100236754	252	38624										
KLHL4	56062	broad.mit.edu	37	chrX	86869502	86869502	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	taatgatgtgcttgaagccaAacaagaagaggtcaggatgg	13	5	1	4			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:86869502A>G	uc004efb.2	+	3	838	c.656A>G	c.(655-657)AAA>AGA	p.K219R	KLHL4_uc004efa.2_Missense_Mutation_p.K219R	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	219	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTTGAAGCCAAACAAGAAGAG	0.378													0	0	0	0.000602	0	5	40										G	86869502	A	G	86869502	3	3	129	1	0	0	0	0	1	0	0	0	8391	14	1	5	666	5	KLHL4	23	86869502	Missense_Mutation	SNP	A	TCGA-K4-A3WU-01B-11D-A23M-08	31835696	86869502	68401058	253	38625										
ODZ1	10178	broad.mit.edu	37	chrX	123554332	123554332	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	caggcaccacaagccatagcGgcattccgcctgcatcacgg	10	16	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:123554332G>A	uc004euj.2	-	24	4854	c.4790C>T	c.(4789-4791)CCG>CTG	p.P1597L	ODZ1_uc011muj.1_Missense_Mutation_p.P1603L|ODZ1_uc010nqy.2_Missense_Mutation_p.P1604L	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1597	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AAGCCATAGCGGCATTCCGCC	0.493													0	0	0	0.004672	0	3	42										A	123554332	G	A	123554332	3	1	129	1	0	0	0	0	1	0	0	0	10834	1116	39	2	3419	2	ODZ1	23	123554332	Missense_Mutation	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	36684830	123554332	31716228	254	38626										
DCAF12L1	139170	broad.mit.edu	37	chrX	125685907	125685907	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gctatgccaggcaacagtgtCatcgaacttgtccgggtcca	11	12	1	0			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:125685907C>T	uc004eul.2	-	1	936	c.685G>A	c.(685-687)GAC>AAC	p.D229N		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	229	WD 2.									skin(3)|ovary(1)	4						GCAACAGTGTCATCGAACTTG	0.637													0	0	0	0.006122	0	19	42										T	125685907	C	T	125685907	3	4	129	1	0	0	0	0	1	0	0	0	4264	826	29	1	710	1	DCAF12L1	23	125685907	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	2131575	125685907	29584653	255	38627										
FAM127B	26071	broad.mit.edu	37	chrX	134186001	134186001	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	acgaacatgtaggagctcgtCtgcacgatgaactccgggag	13	10	1	1			TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:134186001C>A	uc004eyf.2	-	1	221	c.138G>T	c.(136-138)CAG>CAT	p.Q46H	FAM127B_uc004eyg.3_Missense_Mutation_p.Q46H	NM_001078172	NP_001071640	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	46											0	Acute lymphoblastic leukemia(192;0.000127)					AGGAGCTCGTCTGCACGATGA	0.652													1	0	2.81731e-10	0.010818	3.0473e-10	32	59										A	134186001	C	A	134186001	3	1	129	1	0	0	0	0	1	0	0	0	5432	912	32	3	271	3	FAM127B	23	134186001	Missense_Mutation	SNP	C	TCGA-K4-A3WU-01B-11D-A23M-08	8500094	134186001	21084559	256	38628										
ARHGEF6	9459	broad.mit.edu	37	chrX	135814312	135814312	+	Frame_Shift_Del	DEL	T	T	-													0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtttcaaatcctttgacggcTtttggggagagaggtctctc							TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:135814312delT	uc004fab.2	-	6	1143	c.681delA	c.(679-681)AAAfs	p.K227fs	ARHGEF6_uc011mwd.1_Frame_Shift_Del_p.K100fs|ARHGEF6_uc011mwe.1_Frame_Shift_Del_p.K73fs	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	227					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					CTTTGACGGCTTTTGGGGAGA	0.328																		2	4	---	---								-	135814312	T	-	135814312	7	5	129	1	0	1	0	1	0	0	0	0	910	1606	56	0	1717	0	ARHGEF6	23	135814312	Frame_Shift_Del	DEL	T	TCGA-K4-A3WU-01B-11D-A23M-08	1628311	135814312	19456248	257	38629										
OPN1LW	5956	broad.mit.edu	37	chrX	153420214	153420214	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.337254901960784	86	6.13922941808709e-28	3.69664031620553	5.27272727272727	2.75098814229249	0.464283058372874	0.68256875146656	63	gtgtggctggccatccgagcGgtaagccccccgattcctcc	12	16	0	0	rs139583770		TCGA-K4-A3WU-01B-11D-A23M-08	TCGA-K4-A3WU-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96f22906-0909-46d1-b737-1d949eb8091e	71d73e3d-61ad-4125-875a-5085ebf382af	g.chrX:153420214G>A	uc004fjz.3	+	4	777	c.744G>A	c.(742-744)GCG>GCA	p.A248A		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	248	Cytoplasmic.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCATCCGAGCGGTAAGCCCCC	0.547													0	0	0	0.00245	0	12	62										A	153420214	G	A	153420214	2	1	129	1	0	0	0	0	0	0	0	1	10877	1130	39	2		2	OPN1LW	23	153420214	Silent	SNP	G	TCGA-K4-A3WU-01B-11D-A23M-08	17605902	153420214	1850346	258	38630										
SCNN1D	6339	broad.mit.edu	37	chr1	1226700	1226700	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ttggggcctccgtcctctccCtcctggagctcctggagctg	12	16	1	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:1226700C>T	uc001adu.1	+	17	2251	c.1627C>T	c.(1627-1629)CTC>TTC	p.L543F	SCNN1D_uc001adt.1_Missense_Mutation_p.L707F|SCNN1D_uc001adw.2_Missense_Mutation_p.L609F|SCNN1D_uc001adx.2_Missense_Mutation_p.L332F|SCNN1D_uc001adv.2_Missense_Mutation_p.L543F	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CGTCCTCTCCCTCCTGGAGCT	0.721													0	0	0	0.014758	0	5	21										T	1226700	C	T	1226700	3	4	130	1	0	0	0	0	1	0	0	0	13929	681	24	2	1883	2	SCNN1D	1	1226700	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		1226700	248023921	1	38631										
ARID1A	8289	broad.mit.edu	37	chr1	27106539	27106539	+	Nonsense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aacaaagtggagtggtggtgGgactgcttggagatgctccg	17	6	0	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:27106539G>A	uc001bmv.1	+	20	6523	c.6150G>A	c.(6148-6150)TGG>TGA	p.W2050*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.W1833*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.W896*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.W378*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.W292*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2050					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGTGGTGGTGGGACTGCTTGG	0.552			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.139131	0	54	49										A	27106539	G	A	27106539	4	1	130	1	0	0	0	0	0	1	0	0	913	1241	43	2	6228	2	ARID1A	1	27106539	Nonsense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	25879839	27106539	222144082	2	38632										
SNIP1	79753	broad.mit.edu	37	chr1	38018319	38018319	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gagacttgcttcttctccctGaggccttgtttttctttttg	8	10	3	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:38018319G>A	uc001cbi.2	-	2	327	c.254C>T	c.(253-255)TCA>TTA	p.S85L	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	85	Arg-rich.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				TCTTCTCCCTGAGGCCTTGTT	0.458													0	0	0	0.139131	0	82	162										A	38018319	G	A	38018319	3	1	130	1	0	0	0	0	1	0	0	0	14848	1294	45	1	948	1	SNIP1	1	38018319	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	10911780	38018319	211232302	3	38633										
FPGT	8790	broad.mit.edu	37	chr1	74670509	74670509	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ttgctgggggtgacattgccGatcttaaattagactctgac	11	8	2	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:74670509G>A	uc001dgb.1	+	4	815	c.778G>A	c.(778-780)GAT>AAT	p.D260N	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	260					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TGACATTGCCGATCTTAAATT	0.358													0	0	0	0.116897	0	29	60										A	74670509	G	A	74670509	3	1	130	1	0	0	0	0	1	0	0	0	6037	1058	37	1	792	1	FPGT	1	74670509	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	36652190	74670509	174580112	4	38634										
F5	2153	broad.mit.edu	37	chr1	169487767	169487767	+	Missense_Mutation	SNP	C	C	G	0	1	1	0	1	0	1	1	0	1	1	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gtgatttgcttgttttctatCtttccattttccatacccag	5	10	2	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:169487767C>G	uc001ggg.1	-	23	6373	c.6228G>C	c.(6226-6228)AAG>AAC	p.K2076N		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2076	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGTTTTCTATCTTTCCATTTT	0.448													0	0	0	0.021553	0	5	40										G	169487767	C	G	169487767	3	3	130	1	0	0	0	0	1	0	0	0	5348	912	32	1	458	1	F5	1	169487767	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	94817258	169487767	79762854	5	38635										
IPO9	55705	broad.mit.edu	37	chr1	201828120	201828120	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ccttgcagacctcaacctctCaggtatgtttcagcacgtgc	8	14	3	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:201828120C>T	uc001gwz.2	+	13	1516	c.1466C>T	c.(1465-1467)TCA>TTA	p.S489L		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	importin 9	489					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			ovary(2)	2						CTCAACCTCTCAGGTATGTTT	0.318													0	0	0	0.105934	0	14	39										T	201828120	C	T	201828120	3	4	130	1	0	0	0	0	1	0	0	0	7799	838	29	1	1516	1	IPO9	1	201828120	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	32340353	201828120	47422501	6	38636										
TP53BP2	7159	broad.mit.edu	37	chr1	223984139	223984139	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	atttagttgggctgagtggcCgaggaattctttcgttttca	12	6	2	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr1:223984139C>T	uc010pvb.1	-	13	2394	c.2102G>A	c.(2101-2103)CGG>CAG	p.R701Q	TP53BP2_uc001hod.2_Missense_Mutation_p.R572Q|TP53BP2_uc010puz.1_5'UTR|TP53BP2_uc010pva.1_Missense_Mutation_p.R340Q	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	695					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCTGAGTGGCCGAGGAATTCT	0.448													0	0	0	0.139131	0	91	102										T	223984139	C	T	223984139	3	4	130	1	0	0	0	0	1	0	0	0	16381	652	23	2	1326	2	TP53BP2	1	223984139	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	22156019	223984139	25266482	7	38637										
TPO	7173	broad.mit.edu	37	chr2	1544451	1544451	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gatgcggaaagcaccaggccGtagggacctcaccgcagcgg	15	13	1	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:1544451G>A	uc002qww.2	+	16	2795	c.2704G>A	c.(2704-2706)GTA>ATA	p.V902I	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.V845I|TPO_uc002qwr.2_Missense_Mutation_p.V902I|TPO_uc002qwx.2_Missense_Mutation_p.V845I|TPO_uc010yio.1_Missense_Mutation_p.V729I|TPO_uc010yip.1_Missense_Mutation_p.V858I|TPO_uc002qwy.1_Missense_Mutation_p.V198I|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	902	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCACCAGGCCGTAGGGACCTC	0.637													0	0	0	0.108266	0	27	73										A	1544451	G	A	1544451	3	1	130	1	0	0	0	0	1	0	0	0	16407	1145	40	2	2762	2	TPO	2	1544451	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08		1544451	241654922	8	38638										
SNRPG	6637	broad.mit.edu	37	chr2	70515288	70515288	+	Nonsense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	taaagggatcaaatccccgcAatattccttggacatgtctg	8	10	2	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:70515288A>T	uc002sgp.2	-	3	180	c.92T>A	c.(91-93)TTG>TAG	p.L31*	SNRPG_uc002sgo.2_RNA	NM_003096	NP_003087	P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G	31					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0						AAATCCCCGCAATATTCCTTG	0.358													0	0	0	0.021553	0	6	100										T	70515288	A	T	70515288	4	4	130	1	0	0	0	0	0	1	0	0	14869	131	5	5	146	5	SNRPG	2	70515288	Nonsense_Mutation	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	68970837	70515288	172684085	9	38639			1	178		2	2	19	N	C_A	4.593402e-05
SNRPG	6637	broad.mit.edu	37	chr2	70515306	70515306	+	Missense_Mutation	SNP	C	C	A	0	1	1	0	1	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gcaatattccttggacatgtCtgccaccatttaatttcact	5	11	2	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:70515306C>A	uc002sgp.2	-	3	162	c.74G>T	c.(73-75)AGA>ATA	p.R25I	SNRPG_uc002sgo.2_RNA	NM_003096	NP_003087	P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G	25					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding				0						TTGGACATGTCTGCCACCATT	0.363													1	0	0.000602214	0.014758	0.000613264	5	83										A	70515306	C	A	70515306	3	1	130	1	0	0	0	0	1	0	0	0	14869	913	32	3	164	3	SNRPG	2	70515306	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	18	70515306	172684067	10	38640			1	178		2	2	19	N	C_A	4.593402e-05
ADD2	119	broad.mit.edu	37	chr2	70890768	70890768	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tgctgaggatttcctctgccGtctgctcctcctccctcccg	8	18	2	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:70890768G>A	uc002sgz.2	-	16	2435	c.1970C>T	c.(1969-1971)ACG>ATG	p.T657M	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.T351M|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	657					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TTCCTCTGCCGTCTGCTCCTC	0.572													0	0	0	0.146539	0	16	151										A	70890768	G	A	70890768	3	1	130	1	0	0	0	0	1	0	0	0	305	1145	40	2	214	2	ADD2	2	70890768	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	375462	70890768	172308605	11	38641										
FER1L5	90342	broad.mit.edu	37	chr2	97370381	97370381	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aaactccacccaggacccacAaatcacctgagtgatatttt	5	13	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:97370381A>G	uc010fia.2	+	52	6234	c.6234A>G	c.(6232-6234)ACA>ACG	p.T2078T	FER1L5_uc002sws.3_Silent_p.T787T|FER1L5_uc002swt.3_Silent_p.T787T|FER1L5_uc010yus.1_Silent_p.T786T	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	2078						integral to membrane				ovary(1)	1						CAGGACCCACAAATCACCTGA	0.527													0	0	0	0.09836	0	41	57										G	97370381	A	G	97370381	2	3	130	1	0	0	0	0	0	0	0	1	5814	117	5	5		5	FER1L5	2	97370381	Silent	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	26479613	97370381	145828992	12	38642										
POU3F3	5455	broad.mit.edu	37	chr2	105473459	105473459	+	Silent	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cctcaccacgggctgcagacGagcgttcagtgaagccaggg	14	13	2	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:105473459G>C	uc010ywg.1	+	1	1491	c.1491G>C	c.(1489-1491)ACG>ACC	p.T497T		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	497					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						GGCTGCAGACGAGCGTTCAGT	0.473													0	0	0	0.150653	0	4	16										C	105473459	G	C	105473459	2	2	130	1	0	0	0	0	0	0	0	1	12276	1045	37	1		1	POU3F3	2	105473459	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	8103078	105473459	137725914	13	38643										
NCKAP5	344148	broad.mit.edu	37	chr2	133539920	133539920	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gaggtgggctttgtttgcacTtggcccttttccacattttc	10	10	0	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:133539920T>G	uc002ttp.2	-	14	4838	c.4464A>C	c.(4462-4464)CAA>CAC	p.Q1488H	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1488							protein binding				0						TTGTTTGCACTTGGCCCTTTT	0.507													0	0	0	0.080935	0	11	108										G	133539920	T	G	133539920	3	3	130	1	0	0	0	0	1	0	0	0	10223	1606	56	5	1293	5	NCKAP5	2	133539920	Missense_Mutation	SNP	T	TCGA-K4-A3WV-01A-11D-A22Z-08	28066461	133539920	109659453	14	38644										
ZRANB3	84083	broad.mit.edu	37	chr2	136107733	136107733	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	atctatcaaagtctttgcatCtgcggttaagagaccataac	7	9	4	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:136107733C>T	uc002tum.2	-	5	529	c.412G>A	c.(412-414)GAT>AAT	p.D138N	ZRANB3_uc002tuk.2_5'UTR|ZRANB3_uc002tul.2_Missense_Mutation_p.D138N|ZRANB3_uc002tun.1_Missense_Mutation_p.D78N	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	138	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		GTCTTTGCATCTGCGGTTAAG	0.373													0	0	0	0.02938	0	5	29										T	136107733	C	T	136107733	3	4	130	1	0	0	0	0	1	0	0	0	18221	913	32	1	2895	1	ZRANB3	2	136107733	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	2567813	136107733	107091640	15	38645										
LRP1B	53353	broad.mit.edu	37	chr2	141079602	141079602	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ggacacacacaagtggccccAgaaggatttagcaagcaaag	11	10	0	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:141079602A>T	uc002tvj.1	-	82	13542	c.12570T>A	c.(12568-12570)TCT>TCA	p.S4190S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4190	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGTGGCCCCAGAAGGATTTA	0.368										TSP Lung(27;0.18)			0	0	0	0.139131	0	48	36										T	141079602	A	T	141079602	2	4	130	1	0	0	0	0	0	0	0	1	8955	175	7	5		5	LRP1B	2	141079602	Silent	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	4971869	141079602	102119771	16	38646										
COL4A3	1285	broad.mit.edu	37	chr2	228104885	228104885	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aagggctttcctggacccccCggttctcctggccagaaagg	12	14	1	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr2:228104885C>T	uc002vom.1	+	3	333	c.171C>T	c.(169-171)CCC>CCT	p.P57P	COL4A3_uc002von.1_Silent_p.P57P|COL4A3_uc002voo.1_Silent_p.P57P|COL4A3_uc002vop.1_Silent_p.P57P|uc002voq.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	57	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CTGGACCCCCCGGTTCTCCTG	0.517													0	0	0	0.11911	0	14	2										T	228104885	C	T	228104885	2	4	130	1	0	0	0	0	0	0	0	1	3691	639	23	2		2	COL4A3	2	228104885	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	87025283	228104885	15094488	17	38647										
GTPBP8	29083	broad.mit.edu	37	chr3	112715770	112715770	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	catttttattagtggatagcGttgttggaattcaaaaaaca	8	4	1	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr3:112715770G>C	uc003dzn.2	+	4	645	c.598G>C	c.(598-600)GTT>CTT	p.V200L	GTPBP8_uc011bhy.1_RNA|GTPBP8_uc003dzp.2_RNA|GTPBP8_uc003dzo.2_Missense_Mutation_p.V167L	NM_014170	NP_054889	Q8N3Z3	GTPB8_HUMAN	GTP-binding protein 8 isoform 1	200	G.				barrier septum formation		GTP binding				0						AGTGGATAGCGTTGTTGGAAT	0.318													0	0	0	0.021553	0	6	64										C	112715770	G	C	112715770	3	2	130	1	0	0	0	0	1	0	0	0	6884	1145	40	4	612	4	GTPBP8	3	112715770	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08		112715770	85306660	18	38648										
ZIC1	7545	broad.mit.edu	37	chr3	147128234	147128234	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gggttttggcgacgcggcggCggcagccagcgcacagcaca	17	13	0	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr3:147128234C>T	uc003ewe.2	+	1	1054	c.335C>T	c.(334-336)GCG>GTG	p.A112V		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	112	Poly-Ala.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GACGCGGCGGCGGCAGCCAGC	0.701													0	0	0	0.038147	0	7	70										T	147128234	C	T	147128234	3	4	130	1	0	0	0	0	1	0	0	0	17675	768	27	2	337	2	ZIC1	3	147128234	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	34412464	147128234	50894196	19	38649										
DGKQ	1609	broad.mit.edu	37	chr4	961427	961427	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tcgccatcaaagatcttcagCgtttgcttccctgggccggg	11	13	3	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr4:961427C>T	uc003gbw.2	-	8	971	c.897G>A	c.(895-897)ACG>ACA	p.T299T	DGKQ_uc010ibn.2_Silent_p.T299T	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	299					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			AGATCTTCAGCGTTTGCTTCC	0.667													0	0	0	0.132662	0	14	16										T	961427	C	T	961427	2	4	130	1	0	0	0	0	0	0	0	1	4473	755	27	2		2	DGKQ	4	961427	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		961427	190192849	20	38650										
NSUN7	79730	broad.mit.edu	37	chr4	40752759	40752759	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tttcgaacgaagaagatcccGagatcatctcccaactcact	6	13	3	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr4:40752759G>A	uc003gvj.3	+	2	544	c.49G>A	c.(49-51)GAG>AAG	p.E17K	NSUN7_uc003gvh.2_Missense_Mutation_p.E17K|NSUN7_uc003gvi.3_Missense_Mutation_p.E17K	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						AGAAGATCCCGAGATCATCTC	0.552													0	0	0	0.069288	0	23	46										A	40752759	G	A	40752759	3	1	130	1	0	0	0	0	1	0	0	0	10683	1059	37	1	51	1	NSUN7	4	40752759	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	39791332	40752759	150401517	21	38651										
IGJ	3512	broad.mit.edu	37	chr4	71522981	71522981	+	Silent	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aatggtgaggtgggatcagaGatattctccctgttgttcag	13	6	3	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr4:71522981G>T	uc003hfn.3	-	3	357	c.216C>A	c.(214-216)ATC>ATA	p.I72I	IGJ_uc010ihz.2_Silent_p.I88I	NM_144646	NP_653247	P01591	IGJ_HUMAN	immunoglobulin J chain	72					immune response	extracellular region	antigen binding				0			Lung(101;0.235)			TGGGATCAGAGATATTCTCCC	0.323													1	0	1.96292e-10	0.055883	2.13612e-10	18	70										T	71522981	G	T	71522981	2	4	130	1	0	0	0	0	0	0	0	1	7592	932	33	3		3	IGJ	4	71522981	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	30770222	71522981	119631295	22	38652										
PCDHA9	9752	broad.mit.edu	37	chr5	140229323	140229323	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tgctggacagagctctggacCgcgagagtgtgtccgcctac	14	12	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:140229323C>T	uc003lhu.2	+	1	1967	c.1243C>T	c.(1243-1245)CGC>TGC	p.R415C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.R415C	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	415	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTCTGGACCGCGAGAGTGT	0.642													0	0	0	0.163468	0	33	125										T	140229323	C	T	140229323	3	4	130	1	0	0	0	0	1	0	0	0	11531	652	23	2	1245	2	PCDHA9	5	140229323	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		140229323	40685937	23	38653										
PCDHA9	9752	broad.mit.edu	37	chr5	140229587	140229587	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	agcggcggttgggcgagcgcTcgctgtcgagctacgtgtca	17	11	1	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:140229587T>G	uc003lhu.2	+	1	2231	c.1507T>G	c.(1507-1509)TCG>GCG	p.S503A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.S503A	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCGAGCGCTCGCTGTCGAG	0.672													0	0	0	0.173368	0	30	167										G	140229587	T	G	140229587	3	3	130	1	0	0	0	0	1	0	0	0	11531	1551	54	5	1509	5	PCDHA9	5	140229587	Missense_Mutation	SNP	T	TCGA-K4-A3WV-01A-11D-A22Z-08	264	140229587	40685673	24	38654										
PRR7	80758	broad.mit.edu	37	chr5	176882976	176882976	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ctcggcccgcgccgccctgcCcagccctctgcctgcaggcc	11	23	1	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:176882976C>T	uc003mgu.1	+	4	1171	c.679C>T	c.(679-681)CCA>TCA	p.P227S	PRR7_uc003mgv.1_Missense_Mutation_p.P227S|PRR7_uc003mgw.1_Missense_Mutation_p.P227S	NM_030567	NP_085044	Q8TB68	PRR7_HUMAN	proline rich 7 (synaptic)	227	Pro-rich.|Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane					0	all_cancers(89;1.51e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGCCCTGCCCAGCCCTCTG	0.746													0	0	0	0.02938	0	7	5										T	176882976	C	T	176882976	3	4	130	1	0	0	0	0	1	0	0	0	12603	623	22	2	685	2	PRR7	5	176882976	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	36653389	176882976	4032284	25	38655										
ZNF354A	6940	broad.mit.edu	37	chr5	178139989	178139989	+	Missense_Mutation	SNP	G	G	C	1	0	0	0	0	1	1	1	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cacattctttacatctgtagGatttctccacagtatgggtt	7	9	3	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr5:178139989G>C	uc003mjj.2	-	5	1088	c.890C>G	c.(889-891)TCC>TGC	p.S297C		NM_005649	NP_005640	O60765	Z354A_HUMAN	zinc finger protein 354A	297					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		ACATCTGTAGGATTTCTCCAC	0.378													0	0	0	0.076483	0	24	78										C	178139989	G	C	178139989	3	2	130	1	0	0	0	0	1	0	0	0	17861	1174	41	1	931	1	ZNF354A	5	178139989	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	1257013	178139989	2775271	26	38656										
DSP	1832	broad.mit.edu	37	chr6	7580718	7580718	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ggtggaagaagacatccaacAgcaaaaggccactggctctg	12	10	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr6:7580718A>C	uc003mxp.1	+	23	4574	c.4295A>C	c.(4294-4296)CAG>CCG	p.Q1432P	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1432	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GACATCCAACAGCAAAAGGCC	0.488													0	0	0	0.049695	0	19	63										C	7580718	A	C	7580718	3	2	130	1	0	0	0	0	1	0	0	0	4781	188	7	5	4385	5	DSP	6	7580718	Missense_Mutation	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08		7580718	163534349	27	38657										
RIMS1	22999	broad.mit.edu	37	chr6	72889512	72889512	+	Missense_Mutation	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cccaggatgctgctcctcccAgcgcaccaccagacaggagc	10	18	0	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr6:72889512A>T	uc003pga.2	+	5	783	c.706A>T	c.(706-708)AGC>TGC	p.S236C	RIMS1_uc011dyb.1_5'Flank|RIMS1_uc003pgc.2_5'Flank|RIMS1_uc003pgb.3_5'Flank	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	236					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGCTCCTCCCAGCGCACCACC	0.587													0	0	0	0.104719	0	41	22										T	72889512	A	T	72889512	3	4	130	1	0	0	0	0	1	0	0	0	13367	188	7	5	724	5	RIMS1	6	72889512	Missense_Mutation	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	65308794	72889512	98225555	28	38658										
BBS9	27241	broad.mit.edu	37	chr7	33217147	33217147	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gatgaaattgatgtatgaacAtaatcttcagagaacagcct	8	6	2	4			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:33217147A>G	uc003tdn.1	+	5	899	c.386A>G	c.(385-387)CAT>CGT	p.H129R	BBS9_uc003tdo.1_Missense_Mutation_p.H129R|BBS9_uc003tdp.1_Missense_Mutation_p.H129R|BBS9_uc003tdq.1_Missense_Mutation_p.H129R|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.H129R|BBS9_uc011kao.1_Missense_Mutation_p.H7R	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	129					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			ATGTATGAACATAATCTTCAG	0.343									Bardet-Biedl_syndrome				0	0	0	0.139131	0	51	55										G	33217147	A	G	33217147	3	3	130	1	0	0	0	0	1	0	0	0	1342	217	8	5	400	5	BBS9	7	33217147	Missense_Mutation	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08		33217147	125921516	29	38659										
POU6F2	11281	broad.mit.edu	37	chr7	39472816	39472816	+	Silent	SNP	G	G	T	1	0	0	0	0	1	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	atcatcgccacagtcattggGaaccagatcctgcccgtgat	9	13	2	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:39472816G>T	uc003thb.1	+	7	1209	c.1167G>T	c.(1165-1167)GGG>GGT	p.G389G		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	389	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CAGTCATTGGGAACCAGATCC	0.612													1	0	5.50884e-06	0.09319	5.71477e-06	12	76										T	39472816	G	T	39472816	2	4	130	1	0	0	0	0	0	0	0	1	12285	1161	41	3		3	POU6F2	7	39472816	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	6255669	39472816	119665847	30	38660										
SSPO	23145	broad.mit.edu	37	chr7	149508082	149508082	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cccgggcagcactgtggttcGtccatgtgaaaactggtgag	14	10	0	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr7:149508082G>A	uc010lpk.2	+	67	9476	c.9476G>A	c.(9475-9477)CGT>CAT	p.R3159H		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	3159					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACTGTGGTTCGTCCATGTGAA	0.607													0	0	0	0.080935	0	12	36										A	149508082	G	A	149508082	3	1	130	1	0	0	0	0	1	0	0	0	15188	1145	40	2	9732	2	SSPO	7	149508082	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	110035266	149508082	9630581	31	38661										
C8orf74	203076	broad.mit.edu	37	chr8	10555320	10555320	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tgcatgccaccccatcccctCccgctggccgagggcatgga	11	18	0	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr8:10555320C>T	uc003wtd.1	+	3	482	c.453C>T	c.(451-453)CTC>CTT	p.L151L	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	151											0				COAD - Colon adenocarcinoma(149;0.0811)		CCCATCCCCTCCCGCTGGCCG	0.652													0	0	0	0.183431	0	34	38										T	10555320	C	T	10555320	2	4	130	1	0	0	0	0	0	0	0	1	2436	842	30	1		1	C8orf74	8	10555320	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		10555320	135808702	32	38662										
ZHX2	22882	broad.mit.edu	37	chr8	123965291	123965291	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	caaagaccagttggccatcgCggcctcccgacacggtcgca	11	16	0	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr8:123965291C>T	uc003ypk.1	+	3	2108	c.1541C>T	c.(1540-1542)GCG>GTG	p.A514V		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	514						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			TTGGCCATCGCGGCCTCCCGA	0.537													0	0	0	0.163468	0	33	18										T	123965291	C	T	123965291	3	4	130	1	0	0	0	0	1	0	0	0	17673	768	27	2	1543	2	ZHX2	8	123965291	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	113409971	123965291	22398731	33	38663										
EPPK1	83481	broad.mit.edu	37	chr8	144940347	144940347	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gcgccggtaggccacgtccaCgggcacgcggtggctgtgca	17	14	0	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr8:144940347C>T	uc003zaa.1	-	2	15098	c.15085G>A	c.(15085-15087)GTG>ATG	p.V5029M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5029	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCACGTCCACGGGCACGCGG	0.692													0	0	0	0.139131	0	49	731										T	144940347	C	T	144940347	3	4	130	1	0	0	0	0	1	0	0	0	5190	536	19	2	191	2	EPPK1	8	144940347	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	20975056	144940347	1423675	34	38664										
TLE1	7088	broad.mit.edu	37	chr9	84300624	84300624	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tcaatgtttaatccatatgaCatttcataatactgtaaaga	4	6	2	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:84300624C>A	uc004aly.2	-	4	642	c.201G>T	c.(199-201)ATG>ATT	p.M67I	TLE1_uc004alz.2_Missense_Mutation_p.M67I|TLE1_uc011lsr.1_Missense_Mutation_p.M67I|TLE1_uc004ama.1_Missense_Mutation_p.M67I|TLE1_uc011lss.1_Missense_Mutation_p.M67I|TLE1_uc004amb.2_Missense_Mutation_p.M67I	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	67	Gln-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						ATCCATATGACATTTCATAAT	0.294													1	0	5.9392e-07	0.021553	6.27858e-07	5	11										A	84300624	C	A	84300624	3	1	130	1	0	0	0	0	1	0	0	0	15935	478	17	4	2179	4	TLE1	9	84300624	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		84300624	56912807	35	38665										
HABP4	22927	broad.mit.edu	37	chr9	99250477	99250477	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	taacctccctcgtcctgggcGtggagccagaggaggcaccc	13	15	0	1	rs141094261	byFrequency	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:99250477G>A	uc010msg.2	+	7	1254	c.1106G>A	c.(1105-1107)CGT>CAT	p.R369H	HABP4_uc010msh.2_Missense_Mutation_p.R264H	NM_014282	NP_055097	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	369					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				CGTCCTGGGCGTGGAGCCAGA	0.552													0	0	0	0.055883	0	22	33										A	99250477	G	A	99250477	3	1	130	1	0	0	0	0	1	0	0	0	6939	1145	40	2	1132	2	HABP4	9	99250477	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	14949853	99250477	41962954	36	38666										
SVEP1	79987	broad.mit.edu	37	chr9	113168736	113168736	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ccagagctccactggccatcGgcttcacaggtgatttcaga	10	13	2	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:113168736G>A	uc010mtz.2	-	38	9481	c.9144C>T	c.(9142-9144)GCC>GCT	p.A3048A	SVEP1_uc010mty.2_Silent_p.A974A	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3048	Sushi 27.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACTGGCCATCGGCTTCACAGG	0.498													0	0	0	0.055883	0	20	50										A	113168736	G	A	113168736	2	1	130	1	0	0	0	0	0	0	0	1	15417	1103	39	2		2	SVEP1	9	113168736	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	13918259	113168736	28044695	37	38667										
PAPPA	5069	broad.mit.edu	37	chr9	119115032	119115032	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aggatgggctgtggtccttcCcagaggccctgtgtgagctc	15	11	0	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:119115032C>G	uc004bjn.2	+	16	4393	c.4012C>G	c.(4012-4014)CCA>GCA	p.P1338A	PAPPA_uc011lxq.1_Missense_Mutation_p.P713A	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1338	Sushi 2.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GTGGTCCTTCCCAGAGGCCCT	0.602													0	0	0	0.0918	0	24	21										G	119115032	C	G	119115032	3	3	130	1	0	0	0	0	1	0	0	0	11432	623	22	4	4074	4	PAPPA	9	119115032	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	5946296	119115032	22098399	38	38668										
SNAPC4	6621	broad.mit.edu	37	chr9	139273307	139273307	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cctcggcctctgagaagacaGgagcgaggggcagggcttgc	17	11	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr9:139273307G>A	uc004chh.2	-	21	2981	c.2972C>T	c.(2971-2973)CCT>CTT	p.P991L		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	991	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TGAGAAGACAGGAGCGAGGGG	0.667													0	0	0	0.02938	0	7	7										A	139273307	G	A	139273307	3	1	130	1	0	0	0	0	1	0	0	0	14837	1000	35	2	1445	2	SNAPC4	9	139273307	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	20158275	139273307	1940124	39	38669										
RBM17	84991	broad.mit.edu	37	chr10	6139098	6139098	+	Frame_Shift_Del	DEL	A	A	-													0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aaggctggtccaaaaacttcAaacttctgcagtctcagctt							TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:6139098delA	uc001ijb.2	+	2	296	c.70delA	c.(70-72)AAAfs	p.K24fs	RBM17_uc010qav.1_Frame_Shift_Del_p.K24fs	NM_032905	NP_116294	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	24					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						CAAAAACTTCAAACTTCTGCA	0.478																		32	101	---	---								-	6139098	A	-	6139098	7	5	130	1	0	1	0	1	0	0	0	0	13119	131	5	0	72	0	RBM17	10	6139098	Frame_Shift_Del	DEL	A	TCGA-K4-A3WV-01A-11D-A22Z-08		6139098	129395649	40	38670										
CYP26C1	340665	broad.mit.edu	37	chr10	94821038	94821038	+	Silent	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	atcatgttcccttgggggctGagctgcctgtcagtgctggg	15	10	2	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:94821038G>A	uc010qns.1	+	1	18	c.18G>A	c.(16-18)CTG>CTA	p.L6L	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	6					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				CTTGGGGGCTGAGCTGCCTGT	0.711													0	0	0	0.021553	0	6	4										A	94821038	G	A	94821038	2	1	130	1	0	0	0	0	0	0	0	1	4157	1277	45	1		1	CYP26C1	10	94821038	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	88681940	94821038	40713709	41	38671										
C10orf12	26148	broad.mit.edu	37	chr10	98743230	98743230	+	Missense_Mutation	SNP	G	G	A	1	0	0	1	0	1	1	0	1	1	0	1	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	acacccagcagaaagatgatGagagtgatgccccatgcagc	11	11	0	5			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:98743230G>A	uc001kmv.2	+	1	2190	c.2083G>A	c.(2083-2085)GAG>AAG	p.E695K		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	695										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		GAAAGATGATGAGAGTGATGC	0.517													0	0	0	0.105934	0	14	55										A	98743230	G	A	98743230	3	1	130	1	0	0	0	0	1	0	0	0	1589	1291	45	1	2085	1	C10orf12	10	98743230	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	3922192	98743230	36791517	42	38672										
ABCC2	1244	broad.mit.edu	37	chr10	101571351	101571351	+	Silent	SNP	A	A	T	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gaacatgattcggaagccacAgtccgagagtgagttgcctt	12	9	0	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr10:101571351A>T	uc001kqf.2	+	15	2098	c.1959A>T	c.(1957-1959)ACA>ACT	p.T653T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	653	Cytoplasmic (By similarity).|ABC transporter 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CGGAAGCCACAGTCCGAGAGT	0.453													0	0	0	0.086207	0	36	37										T	101571351	A	T	101571351	2	4	130	1	0	0	0	0	0	0	0	1	53	175	7	5		5	ABCC2	10	101571351	Silent	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	2828121	101571351	33963396	43	38673										
ANO5	203859	broad.mit.edu	37	chr11	22249087	22249087	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cggcaggagctcttcctcatCgaagatcaggcaaccttctt	9	13	4	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:22249087C>T	uc001mqi.2	+	7	920	c.603C>T	c.(601-603)ATC>ATT	p.I201I	ANO5_uc001mqj.2_Silent_p.I200I	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	201	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TCTTCCTCATCGAAGATCAGG	0.453													0	0	0	0.076483	0	25	61										T	22249087	C	T	22249087	2	4	130	1	0	0	0	0	0	0	0	1	700	874	31	1		1	ANO5	11	22249087	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		22249087	112757429	44	38674										
FIBIN	387758	broad.mit.edu	37	chr11	27016101	27016101	+	Missense_Mutation	SNP	A	A	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ttctgaagttcttctgcatgAgtttcttctgccacctgtgt	8	10	5	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:27016101A>C	uc001mrd.2	+	1	474	c.28A>C	c.(28-30)AGT>CGT	p.S10R		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	10						extracellular region|Golgi apparatus					0						CTTCTGCATGAGTTTCTTCTG	0.527													0	0	0	0.09836	0	36	25										C	27016101	A	C	27016101	3	2	130	1	0	0	0	0	1	0	0	0	5885	304	11	5	30	5	FIBIN	11	27016101	Missense_Mutation	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	4767014	27016101	107990415	45	38675										
OR5M8	219484	broad.mit.edu	37	chr11	56258428	56258428	+	Missense_Mutation	SNP	C	C	A	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gcaccgtgatgaggaaggagCacacactcttggacattctg	12	10	2	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:56258428C>A	uc001nix.1	-	1	419	c.419G>T	c.(418-420)TGC>TTC	p.C140F		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GAGGAAGGAGCACACACTCTT	0.522													1	0	1.17739e-12	0.108266	1.29397e-12	29	44										A	56258428	C	A	56258428	3	1	130	1	0	0	0	0	1	0	0	0	11176	710	25	4	520	4	OR5M8	11	56258428	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	29242327	56258428	78748088	46	38676										
CTSW	1521	broad.mit.edu	37	chr11	65649734	65649734	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ataaggtctgaagagccagaGgagtcagtacctttcagctg	12	8	3	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:65649734G>A	uc001ogc.1	+	4	417	c.375G>A	c.(373-375)GAG>GAA	p.E125E	CTSW_uc001ogb.1_Silent_p.E125E	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	125					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)		AAGAGCCAGAGGAGTCAGTAC	0.582													0	0	0	0.069288	0	21	120										A	65649734	G	A	65649734	2	1	130	1	0	0	0	0	0	0	0	1	4042	991	35	2		2	CTSW	11	65649734	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	9391306	65649734	69356782	47	38677										
FAT3	120114	broad.mit.edu	37	chr11	92623737	92623737	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tgcccaactatgagaaccagGatggagggtctgcacaccag	12	11	1	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:92623737G>A	uc001pdj.3	+	25	13149	c.13132G>A	c.(13132-13134)GAT>AAT	p.D4378N	FAT3_uc001pdi.3_Missense_Mutation_p.D850N	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4410	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAGAACCAGGATGGAGGGTC	0.547										TCGA Ovarian(4;0.039)			0	0	0	0.069234	0	11	24										A	92623737	G	A	92623737	3	1	130	1	0	0	0	0	1	0	0	0	5691	1174	41	1	13230	1	FAT3	11	92623737	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	26974003	92623737	42382779	48	38678										
BUD13	84811	broad.mit.edu	37	chr11	116619253	116619253	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cctccactgccttcttgctgGcaagcctggcaaagcgcttc	9	16	1	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:116619253G>A	uc001ppn.2	-	10	1839	c.1805C>T	c.(1804-1806)GCC>GTC	p.A602V	BUD13_uc001ppo.2_Missense_Mutation_p.A468V	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	602										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTTCTTGCTGGCAAGCCTGGC	0.478													0	0	0	0.0918	0	24	34										A	116619253	G	A	116619253	3	1	130	1	0	0	0	0	1	0	0	0	1573	1203	42	2	58	2	BUD13	11	116619253	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	23995516	116619253	18387263	49	38679										
APOC3	345	broad.mit.edu	37	chr11	116701559	116701559	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	atgaagcacgccaccaagacCgccaaggatgcactgagcag	11	13	0	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr11:116701559C>T	uc001ppt.1	+	3	172	c.126C>T	c.(124-126)ACC>ACT	p.T42T		NM_000040	NP_000031	P02656	APOC3_HUMAN	apolipoprotein C-III precursor	42					Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol import|negative regulation of fatty acid biosynthetic process|negative regulation of high-density lipoprotein particle clearance|negative regulation of lipoprotein lipase activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor-mediated endocytosis|negative regulation of triglyceride catabolic process|negative regulation of very-low-density lipoprotein particle clearance|negative regulation of very-low-density lipoprotein particle remodeling|phospholipid efflux|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle assembly	chylomicron|intermediate-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	high-density lipoprotein particle receptor binding|lipase inhibitor activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CCACCAAGACCGCCAAGGATG	0.647													0	0	0	0.021553	0	6	17										T	116701559	C	T	116701559	2	4	130	1	0	0	0	0	0	0	0	1	799	639	23	2		2	APOC3	11	116701559	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	82306	116701559	18304957	50	38680										
NTF3	4908	broad.mit.edu	37	chr12	5603608	5603609	+	Frame_Shift_Ins	INS	-	-	C													0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gagagccggagcggggagggINScccgccaagtcagcattcca							TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:5603608_5603609insC	uc001qnl.3	+	1	311_312	c.228_229insC	c.(226-231)GGGCCCfs	p.G76fs	NTF3_uc001qnk.3_Frame_Shift_Ins_p.G89fs	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	76_77					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						AGCGGGGAGGGCCCGCCAAGTC	0.579																		37	87	---	---								C	5603609	-	C	5603608	7	5	130	1	0	1	1	0	0	0	0	0	10696	1190	42	0	273	0	NTF3	12	5603608	Frame_Shift_Ins	INS	-	TCGA-K4-A3WV-01A-11D-A22Z-08		5603608	128248287	51	38681										
KIF21A	55605	broad.mit.edu	37	chr12	39760203	39760203	+	Silent	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gccctctcgcctgtagctccAgtacgcttcagtctttcaga	8	15	4	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:39760203A>G	uc001rly.2	-	6	998	c.852T>C	c.(850-852)ACT>ACC	p.T284T	KIF21A_uc001rlx.2_Silent_p.T284T|KIF21A_uc001rlz.2_Silent_p.T284T|KIF21A_uc010skl.1_Silent_p.T284T|KIF21A_uc001rma.1_Silent_p.T292T	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	284	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CTGTAGCTCCAGTACGCTTCA	0.393													0	0	0	0.099896	0	25	53										G	39760203	A	G	39760203	2	3	130	1	0	0	0	0	0	0	0	1	8288	175	7	5		5	KIF21A	12	39760203	Silent	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	34156595	39760203	94091692	52	38682										
GDF11	10220	broad.mit.edu	37	chr12	56143622	56143622	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	acaagcagcagattatctacGgcaagatccctggcatggtg	11	10	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:56143622G>A	uc001shq.2	+	3	1217	c.1180G>A	c.(1180-1182)GGC>AGC	p.G394S	GDF11_uc010spv.1_Missense_Mutation_p.G394S	NM_005811	NP_005802	O95390	GDF11_HUMAN	growth differentiation factor 11 precursor	394					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity			kidney(1)	1						GATTATCTACGGCAAGATCCC	0.572													0	0	0	0.183431	0	34	133										A	56143622	G	A	56143622	3	1	130	1	0	0	0	0	1	0	0	0	6312	1116	39	2	1190	2	GDF11	12	56143622	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	16383419	56143622	77708273	53	38683										
PTPRB	5787	broad.mit.edu	37	chr12	70953310	70953310	+	Missense_Mutation	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aaccactgcagctcaaagtcGttgtagtctgtccagtctgg	10	11	3	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:70953310G>T	uc001swb.3	-	16	3903	c.3873C>A	c.(3871-3873)AAC>AAA	p.N1291K	PTPRB_uc010sto.1_Missense_Mutation_p.N1201K|PTPRB_uc010stp.1_Missense_Mutation_p.N1201K|PTPRB_uc001swc.3_Missense_Mutation_p.N1509K|PTPRB_uc001swa.3_Missense_Mutation_p.N1421K|PTPRB_uc001swd.3_Missense_Mutation_p.N1508K|PTPRB_uc009zrr.1_Missense_Mutation_p.N1388K	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1291	Fibronectin type-III 15.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTCAAAGTCGTTGTAGTCTG	0.493													1	0	5.00936e-31	0.139131	5.61655e-31	66	196										T	70953310	G	T	70953310	3	4	130	1	0	0	0	0	1	0	0	0	12796	1136	40	4	2188	4	PTPRB	12	70953310	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	14809688	70953310	62898585	54	38684										
C12orf51	283450	broad.mit.edu	37	chr12	112670808	112670808	+	Missense_Mutation	SNP	C	C	G	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ttttaacctcatgaggttacCttggtcatgtctcgatccat	7	10	3	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr12:112670808C>G	uc009zwc.2	-	31	4749	c.4731G>C	c.(4729-4731)AAG>AAC	p.K1577N		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						ATGAGGTTACCTTGGTCATGT	0.403													0	0	0	0.02938	0	7	6										G	112670808	C	G	112670808	3	3	130	1	0	0	0	0	1	0	0	0	1696	695	24	4	7415	4	C12orf51	12	112670808	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	41717498	112670808	21181087	55	38685										
SLC8A3	6547	broad.mit.edu	37	chr14	70515701	70515701	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	acagtcaggaagtgcatgacGtagtcaaagcaggagggcag	15	7	2	1	rs149109491	byFrequency	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr14:70515701G>A	uc001xly.2	-	7	2944	c.2190C>T	c.(2188-2190)TAC>TAT	p.Y730Y	SLC8A3_uc001xlu.2_Silent_p.Y87Y|SLC8A3_uc001xlv.2_Silent_p.Y101Y|SLC8A3_uc001xlw.2_Silent_p.Y727Y|SLC8A3_uc001xlx.2_Silent_p.Y728Y|SLC8A3_uc001xlz.2_Silent_p.Y724Y|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Silent_p.Y87Y	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	730	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGTGCATGACGTAGTCAAAGC	0.572													0	0	0	0.108266	0	28	43										A	70515701	G	A	70515701	2	1	130	1	0	0	0	0	0	0	0	1	14708	1140	40	2		2	SLC8A3	14	70515701	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08		70515701	36833839	56	38686										
DICER1	23405	broad.mit.edu	37	chr14	95579563	95579563	+	Splice_Site	SNP	T	T	A	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tggtaatctagcacagtatcTgtgaagaaaaagaaattctg	9	5	3	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr14:95579563T>A	uc001ydw.2	-	13	2090	c.1908_splice	c.e13-1	p.R636_splice	DICER1_uc001ydv.2_Splice_Site_p.R626_splice|DICER1_uc001ydx.2_Splice_Site_p.R636_splice	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1						negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		GCACAGTATCTGTGAAGAAAA	0.378			Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.069288	0	23	55										A	95579563	T	A	95579563	5	1	130	1	0	0	0	0	0	0	1	0	4521	1594	55	5	3926	5	DICER1	14	95579563	Splice_Site	SNP	T	TCGA-K4-A3WV-01A-11D-A22Z-08	25063862	95579563	11769977	57	38687										
SEMA6D	80031	broad.mit.edu	37	chr15	48052549	48052549	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	acgcccttcaggcaatgaatCgcagcacaggctggactttc	10	13	1	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr15:48052549C>T	uc010bek.2	+	3	518	c.158C>T	c.(157-159)TCG>TTG	p.S53L	SEMA6D_uc001zvw.2_Missense_Mutation_p.S53L|SEMA6D_uc001zvx.1_Missense_Mutation_p.S53L|SEMA6D_uc001zvy.2_Missense_Mutation_p.S53L|SEMA6D_uc001zvz.2_Missense_Mutation_p.S53L|SEMA6D_uc001zwa.2_Missense_Mutation_p.S53L|SEMA6D_uc001zwb.2_Missense_Mutation_p.S53L|SEMA6D_uc001zwc.2_Missense_Mutation_p.S53L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	53	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GGCAATGAATCGCAGCACAGG	0.408													0	0	0	0.047766	0	9	50										T	48052549	C	T	48052549	3	4	130	1	0	0	0	0	1	0	0	0	14042	893	31	1	164	1	SEMA6D	15	48052549	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		48052549	54478843	58	38688										
CA12	771	broad.mit.edu	37	chr15	63637770	63637770	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gcagctgcgtggcactgtagCgagactggaggccctggatg	17	10	0	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr15:63637770C>T	uc002amc.2	-	4	491	c.335G>A	c.(334-336)CGC>CAC	p.R112H	CA12_uc002amd.2_Missense_Mutation_p.R112H|CA12_uc002ame.2_Missense_Mutation_p.R52H	NM_001218	NP_001209	O43570	CAH12_HUMAN	carbonic anhydrase XII isoform 1 precursor	112	Extracellular (Potential).				one-carbon metabolic process	integral to membrane	carbonate dehydratase activity|zinc ion binding			ovary(1)	1					Acetazolamide(DB00819)	GGCACTGTAGCGAGACTGGAG	0.657													0	0	0	0.115264	0	3	18										T	63637770	C	T	63637770	3	4	130	1	0	0	0	0	1	0	0	0	2513	768	27	2	761	2	CA12	15	63637770	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	15585221	63637770	38893622	59	38689										
BTBD12	84464	broad.mit.edu	37	chr16	3633236	3633236	+	Missense_Mutation	SNP	T	T	C	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ttgggggtgtgatgctttcaTgatgcttcctttgatgtcgg	14	6	1	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr16:3633236T>C	uc002cvp.2	-	14	5642	c.5015A>G	c.(5014-5016)CAT>CGT	p.H1672R		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1672	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GATGCTTTCATGATGCTTCCT	0.627								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.139131	0	54	57										C	3633236	T	C	3633236	3	2	130	1	0	0	0	0	1	0	0	0	1540	1464	51	5	497	5	BTBD12	16	3633236	Missense_Mutation	SNP	T	TCGA-K4-A3WV-01A-11D-A22Z-08		3633236	86721517	60	38690										
SLC6A2	6530	broad.mit.edu	37	chr16	55719143	55719143	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tgctctgtctgatggtcgtcGtcatcgtcttgtattttagc	10	9	4	1	rs1805066	byFrequency	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr16:55719143G>A	uc002eif.2	+	5	844	c.733G>A	c.(733-735)GTC>ATC	p.V245I	SLC6A2_uc010ccd.2_Missense_Mutation_p.V245I|SLC6A2_uc002eig.2_Missense_Mutation_p.V245I|SLC6A2_uc002eih.2_Missense_Mutation_p.V245I|SLC6A2_uc002eii.2_Missense_Mutation_p.V140I|SLC6A2_uc002eij.2_Missense_Mutation_p.V4I	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	245	Helical; Name=4; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GATGGTCGTCGTCATCGTCTT	0.527													0	0	0	0.055883	0	19	64										A	55719143	G	A	55719143	3	1	130	1	0	0	0	0	1	0	0	0	14683	1145	40	2	838	2	SLC6A2	16	55719143	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	52085907	55719143	34635610	61	38691										
CHD3	1107	broad.mit.edu	37	chr17	7797579	7797579	+	Missense_Mutation	SNP	G	G	T	1	0	0	1	0	1	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cggccaggaaggaagaagaaGaagggtaaggagtgttgact	17	4	0	4			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr17:7797579G>T	uc002gje.2	+	7	1221	c.1071G>T	c.(1069-1071)AAG>AAT	p.K357N	CHD3_uc002gjd.2_Missense_Mutation_p.K416N|CHD3_uc002gjf.2_Missense_Mutation_p.K357N|CHD3_uc002gjg.1_Missense_Mutation_p.K185N	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	357	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGAAGAAGAAGAAGGGTAAGG	0.488													1	0	1.58986e-06	0.069234	1.66486e-06	11	45										T	7797579	G	T	7797579	3	4	130	1	0	0	0	0	1	0	0	0	3326	933	33	3	1378	3	CHD3	17	7797579	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08		7797579	73397631	62	38692										
PYCR1	5831	broad.mit.edu	37	chr17	79892987	79892987	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tggagtgttggtcatgcagcGgatgaccctgggggctggcc	18	9	1	1	rs121918376		TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr17:79892987G>A	uc002kcr.1	-	4	633	c.355C>T	c.(355-357)CGC>TGC	p.R119C	PYCR1_uc002kcq.1_Missense_Mutation_p.R119C|PYCR1_uc002kcp.2_Missense_Mutation_p.R119C|PYCR1_uc002kcs.1_Missense_Mutation_p.R119C|PYCR1_uc010wvd.1_Missense_Mutation_p.R146C|PYCR1_uc002kct.1_Missense_Mutation_p.R119C|PYCR1_uc002kcu.1_Missense_Mutation_p.R119C|PYCR1_uc010wve.1_Missense_Mutation_p.R71C	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	119			R -> H (in ARCL2B).|R -> G (in ARCL2B).		cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	GTCATGCAGCGGATGACCCTG	0.647													0	0	0	0.043863	0	18	24										A	79892987	G	A	79892987	3	1	130	1	0	0	0	0	1	0	0	0	12855	1116	39	2	708	2	PYCR1	17	79892987	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	72095408	79892987	1302223	63	38693										
MUC16	94025	broad.mit.edu	37	chr19	9063763	9063763	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tgctgattctgtcatgacagGggatgtagagaaccagctga	13	7	2	4			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:9063763G>A	uc002mkp.2	-	3	23887	c.23683C>T	c.(23683-23685)CCT>TCT	p.P7895S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7897	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCATGACAGGGGATGTAGAG	0.498													0	0	0	0.092188	0	40	70										A	9063763	G	A	9063763	3	1	130	1	0	0	0	0	1	0	0	0	9973	1232	43	2	20168	2	MUC16	19	9063763	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08		9063763	50065220	64	38694										
DOCK6	57572	broad.mit.edu	37	chr19	11325227	11325227	+	Splice_Site	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cagatgctggatcaagccctAcctgcacgatgatctccagt	9	13	2	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:11325227A>G	uc002mqs.3	-	33	4244	c.4203_splice	c.e33+1	p.Q1401_splice	DOCK6_uc010xlq.1_Splice_Site_p.Q740_splice	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						ATCAAGCCCTACCTGCACGAT	0.557													0	0	0	0.076483	0	24	27										G	11325227	A	G	11325227	5	3	130	1	0	0	0	0	0	0	1	0	4691	405	14	5	2002	5	DOCK6	19	11325227	Splice_Site	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08	2261464	11325227	47803756	65	38695										
ILVBL	10994	broad.mit.edu	37	chr19	15226826	15226826	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cctcacctcagcatctggccGgcacagcttggccccaagtg	10	17	3	0	rs141415835	by1000genomes	TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:15226826G>A	uc002nam.2	-	13	1649	c.1528C>T	c.(1528-1530)CGG>TGG	p.R510W	ILVBL_uc010xof.1_Missense_Mutation_p.R151W|ILVBL_uc010dzw.2_Missense_Mutation_p.R403W	NM_006844	NP_006835	A1L0T0	ILVBL_HUMAN	ilvB (bacterial acetolactate synthase)-like	510	Thiamine pyrophosphate binding (By similarity).					integral to membrane	magnesium ion binding|thiamine pyrophosphate binding|transferase activity			ovary(2)	2						GCATCTGGCCGGCACAGCTTG	0.597													0	0	0	0.150653	0	4	44										A	15226826	G	A	15226826	3	1	130	1	0	0	0	0	1	0	0	0	7715	1115	39	2	386	2	ILVBL	19	15226826	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	3901599	15226826	43902157	66	38696										
CADM4	199731	broad.mit.edu	37	chr19	44127538	44127538	+	Missense_Mutation	SNP	C	C	T	0	1	1	0	1	0	1	0	1	1	0	1	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gctgccattgaggaaggcttCtcttgcttctccctgttcat	9	12	3	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:44127538C>T	uc002oxc.1	-	9	1160	c.1111G>A	c.(1111-1113)GAA>AAA	p.E371K		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	371	Cytoplasmic (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				AGGAAGGCTTCTCTTGCTTCT	0.592													0	0	0	0.131918	0	42	128										T	44127538	C	T	44127538	3	4	130	1	0	0	0	0	1	0	0	0	2569	922	32	1	59	1	CADM4	19	44127538	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	28900712	44127538	15001445	67	38697										
SYMPK	8189	broad.mit.edu	37	chr19	46341740	46341740	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	agattagccacattatcaggCgtcagcagaggctgcaggaa	12	9	2	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:46341740C>T	uc002pdn.2	-	10	1466	c.1221G>A	c.(1219-1221)ACG>ACA	p.T407T	SYMPK_uc002pdo.1_Silent_p.T407T|SYMPK_uc002pdp.1_Silent_p.T407T|SYMPK_uc002pdq.1_Silent_p.T407T	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	407					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CATTATCAGGCGTCAGCAGAG	0.602													0	0	0	0.047766	0	9	22										T	46341740	C	T	46341740	2	4	130	1	0	0	0	0	0	0	0	1	15436	755	27	2		2	SYMPK	19	46341740	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	2214202	46341740	12787243	68	38698										
PRKD2	25865	broad.mit.edu	37	chr19	47197163	47197163	+	Silent	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tggcctggggcgctgggtgcGtcctgaaggatgacgggcat	19	9	0	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:47197163G>A	uc002pfh.2	-	11	1887	c.1545C>T	c.(1543-1545)GAC>GAT	p.D515D	PRKD2_uc010ekt.2_5'Flank|PRKD2_uc002pfe.2_Silent_p.D35D|PRKD2_uc002pff.2_Silent_p.D35D|PRKD2_uc002pfg.2_Silent_p.D358D|PRKD2_uc002pfi.2_Silent_p.D515D|PRKD2_uc002pfj.2_Silent_p.D515D|PRKD2_uc010xye.1_Silent_p.D515D|PRKD2_uc002pfk.2_Silent_p.D358D	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	515					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CGCTGGGTGCGTCCTGAAGGA	0.687													0	0	0	0.049695	0	19	57										A	47197163	G	A	47197163	2	1	130	1	0	0	0	0	0	0	0	1	12519	1136	40	2		2	PRKD2	19	47197163	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	855423	47197163	11931820	69	38699										
KLK12	43849	broad.mit.edu	37	chr19	51535178	51535178	+	Silent	SNP	G	G	T	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cctgagacgtggcactcggtGccagcggttgcacagtcatt	13	12	1	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr19:51535178G>T	uc002pvg.1	-	3	531	c.411C>A	c.(409-411)GGC>GGA	p.G137G	KLK12_uc010ycp.1_RNA|KLK12_uc010ycq.1_Intron|KLK12_uc010ycr.1_Intron|KLK12_uc010ycs.1_Intron|KLK12_uc002pvh.1_Silent_p.G137G|KLK12_uc002pvi.1_Silent_p.G137G|KLK12_uc002pvj.1_Intron	NM_145894	NP_665901	Q9UKR0	KLK12_HUMAN	kallikrein 12 isoform 2	137	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			ovary(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		GGCACTCGGTGCCAGCGGTTG	0.677													1	0	5.60225e-13	0.144211	6.2185e-13	32	87										T	51535178	G	T	51535178	2	4	130	1	0	0	0	0	0	0	0	1	8400	1306	46	4		4	KLK12	19	51535178	Silent	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	4338015	51535178	7593805	70	38700										
CHGB	1114	broad.mit.edu	37	chr20	5904368	5904368	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gaactgttcaacccatactaCgaccctctccagtggaagag	8	13	2	1	rs138422072		TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr20:5904368C>T	uc002wmg.2	+	4	1884	c.1578C>T	c.(1576-1578)TAC>TAT	p.Y526Y	CHGB_uc010zqz.1_Silent_p.Y209Y	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	526						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ACCCATACTACGACCCTCTCC	0.438													0	0	0	0.021553	0	6	96										T	5904368	C	T	5904368	2	4	130	1	0	0	0	0	0	0	0	1	3339	547	19	2		2	CHGB	20	5904368	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		5904368	57121152	71	38701										
C20orf12	55184	broad.mit.edu	37	chr20	18371024	18371024	+	Missense_Mutation	SNP	T	T	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ctcctttggcaacacttaccTcatccagcagctgttcaatc	5	15	2	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr20:18371024T>G	uc010zsa.1	-	18	2155	c.1946A>C	c.(1945-1947)GAG>GCG	p.E649A	C20orf12_uc010zrz.1_Missense_Mutation_p.E168A|C20orf12_uc002wqp.3_Missense_Mutation_p.E340A|C20orf12_uc002wqr.3_RNA|C20orf12_uc002wqs.3_Missense_Mutation_p.E516A|C20orf12_uc002wqq.3_Missense_Mutation_p.E630A	NM_001099407	NP_001092877	Q9NVP4	CT012_HUMAN	hypothetical protein LOC55184	457	ANK 1.					intracellular	zinc ion binding			ovary(1)	1		Myeloproliferative disorder(85;0.0122)				AACACTTACCTCATCCAGCAG	0.483													0	0	0	0.116897	0	26	91										G	18371024	T	G	18371024	3	3	130	1	0	0	0	0	1	0	0	0	2085	1565	54	5	385	5	C20orf12	20	18371024	Missense_Mutation	SNP	T	TCGA-K4-A3WV-01A-11D-A22Z-08	12466656	18371024	44654496	72	38702										
TOP1	7150	broad.mit.edu	37	chr20	39728847	39728847	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	1	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gatgggcatgctgaagagacGaatcatgcccgaggatataa	13	7	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr20:39728847G>A	uc002xjl.2	+	12	1373	c.1127G>A	c.(1126-1128)CGA>CAA	p.R376Q	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	376					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	CTGAAGAGACGAATCATGCCC	0.507			T	NUP98	AML*								0	0	0	0.0918	0	24	27										A	39728847	G	A	39728847	3	1	130	1	0	0	0	0	1	0	0	0	16360	1058	37	1	1173	1	TOP1	20	39728847	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08	21357823	39728847	23296673	73	38703										
IGSF5	150084	broad.mit.edu	37	chr21	41142905	41142905	+	Missense_Mutation	SNP	G	G	A	1	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ctgagaatgaaccttgtgaaGttacttgtctaccctcacac	7	11	2	3			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr21:41142905G>A	uc002yyo.2	+	4	584	c.481G>A	c.(481-483)GTT>ATT	p.V161I		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	161	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				ACCTTGTGAAGTTACTTGTCT	0.468													0	0	0	0.074837	0	34	46										A	41142905	G	A	41142905	3	1	130	1	0	0	0	0	1	0	0	0	7602	1029	36	2	495	2	IGSF5	21	41142905	Missense_Mutation	SNP	G	TCGA-K4-A3WV-01A-11D-A22Z-08		41142905	6986990	74	38704										
FAM118A	55007	broad.mit.edu	37	chr22	45719182	45719182	+	Silent	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	tggagaagctgcatcgaggcCgtcatcgaggctgcagagca	15	10	1	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chr22:45719182C>T	uc003bfz.3	+	4	790	c.174C>T	c.(172-174)GCC>GCT	p.A58A	FAM118A_uc003bga.3_Silent_p.A58A	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	58						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GCATCGAGGCCGTCATCGAGG	0.642													0	0	0	0.014758	0	5	83										T	45719182	C	T	45719182	2	4	130	1	0	0	0	0	0	0	0	1	5411	639	23	2		2	FAM118A	22	45719182	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08		45719182	5585384	75	38705										
DMD	1756	broad.mit.edu	37	chrX	32486811	32486811	+	Missense_Mutation	SNP	A	A	G	0	0	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	ggccactttgttgctcttgcAgagaactttgtaaagcctaa	9	9	1	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:32486811A>G	uc004dda.1	-	23	3210	c.2966T>C	c.(2965-2967)CTG>CCG	p.L989P	DMD_uc004dcz.2_Missense_Mutation_p.L866P|DMD_uc004dcy.1_Missense_Mutation_p.L985P|DMD_uc004ddb.1_Missense_Mutation_p.L981P|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	989	Spectrin 6.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTGCTCTTGCAGAGAACTTTG	0.328													0	0	0	0.105934	0	14	50										G	32486811	A	G	32486811	3	3	130	1	0	0	0	0	1	0	0	0	4580	188	7	5	8562	5	DMD	23	32486811	Missense_Mutation	SNP	A	TCGA-K4-A3WV-01A-11D-A22Z-08		32486811	122783749	76	38706										
BMP15	9210	broad.mit.edu	37	chrX	50659529	50659529	+	Silent	SNP	C	C	T	0	1	0	0	1	0	1	0	1	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	aagtatgttccaattagtgtCcttatgattgaggcaaatgg	10	5	0	2			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:50659529C>T	uc011mnw.1	+	2	1101	c.1101C>T	c.(1099-1101)GTC>GTT	p.V367V		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	367					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					CAATTAGTGTCCTTATGATTG	0.463													0	0	0	0.076483	0	25	97										T	50659529	C	T	50659529	2	4	130	1	0	0	0	0	0	0	0	1	1458	842	30	1		1	BMP15	23	50659529	Silent	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	18172718	50659529	104611031	77	38707										
RGAG4	340526	broad.mit.edu	37	chrX	71351227	71351227	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	gcactatgggtactggccagCggatgtagctggagacattg	15	8	0	1			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:71351227C>T	uc010nlh.1	-	1	525	c.164G>A	c.(163-165)CGC>CAC	p.R55H	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	55										ovary(2)|skin(1)	3	Renal(35;0.156)					TACTGGCCAGCGGATGTAGCT	0.587													0	0	0	0.055883	0	19	50										T	71351227	C	T	71351227	3	4	130	1	0	0	0	0	1	0	0	0	13275	768	27	2	1549	2	RGAG4	23	71351227	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	20691698	71351227	83919333	78	38708										
TBX22	50945	broad.mit.edu	37	chrX	79283540	79283540	+	Missense_Mutation	SNP	C	C	T	0	1	0	0	0	0	0	0	0	0	0	0	0.0886075949367089	7	0.604891433279213	0.970840480274443	1.22510822510823	0.938380768168002	0.0572755417956657	0.143188854489164	0	cccatggaggccttctttcaCtctcgattttaaaacctttg	6	12	3	0			TCGA-K4-A3WV-01A-11D-A22Z-08	TCGA-K4-A3WV-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0dfb4032-2018-461a-b267-73b5e726dc42	5932e398-bfdc-4fe1-be15-7cd106121d8e	g.chrX:79283540C>T	uc010nmg.1	+	8	1048	c.914C>T	c.(913-915)ACT>ATT	p.T305I	TBX22_uc004edi.1_Missense_Mutation_p.T185I|TBX22_uc004edj.1_Missense_Mutation_p.T305I	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	305					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CCTTCTTTCACTCTCGATTTT	0.383													0	0	0	0.069234	0	11	15										T	79283540	C	T	79283540	3	4	130	1	0	0	0	0	1	0	0	0	15655	565	20	2	940	2	TBX22	23	79283540	Missense_Mutation	SNP	C	TCGA-K4-A3WV-01A-11D-A22Z-08	7932313	79283540	75987020	79	38709										
